
PMID- 29320101
STAT- Publisher
DA  - 20180111
ISBN- 9788281213791
PB  - Knowledge Centre for the Health Services at The Norwegian Institute of Public
      Health (NIPH)
CTI - NIPH Systematic Reviews: Executive Summaries
DP  - 2010 Dec
BTI - Intravenous Thrombolytic Treatment After Acute Stroke and Secondary
      Antithrombotic Prevention Treatment (Antiplatelet and Anticoagulant Treatment)
      After Stroke
AB  - Background Stroke is the third most common cause of death, a major cause of
      severe disability and accounts for considerable consumption of healthcare
      resources. Which medication should be chosen for the treatment of stroke depends 
      on several factors, including efficiency and price. Task requirement The
      Norwegian Directorate of Health's development groups for the preparation of
      national clinical guideline for stroke have commissioned the Norwegian Knowledge 
      Centre for the Health Services to conduct economic evaluations of some central
      recommendations in the stroke guideline. We evaluated the clinical efficacy and
      conducted health economic evaluation of: 1. Intravenous thrombolytic treatment of
      patients with acute stroke (within 3 hours and between 3 to 5 hours after symptom
      onset) in addition to standard treatment compared to treatment without
      thrombolysis 2. Pharmacological secondary prevention of stroke: Antiplatelet
      therapy: acetylsalicylic acid (ASA) combined with slow-release dipyridamole
      compared with ASA monotherapy. Antiplatelet therapy: ASA combined with
      slow-release dipyridamole compared with clopidogrel monotherapy. Anticoagulation 
      therapy with warfarin compared with ASA for prophylaxis of stroke in patients
      with atrial fibrillation. Main Results: Thrombolytic treatment within 3 hours
      after stoke reduces lifetime costs and adds quality-adjusted life years (QALYs)
      compared with standard treatment without thrombolysis for selected stroke
      patients. Thrombolysis given between 3 and 5 hours after stroke is cost-effective
      compared to no thrombolytic treatment. However, the choice of thrombolysis in
      this time interval should also be carefully considered from an ethical
      perspective, because it leads to shorter life expectancy relative to no
      thrombolytic treatment. The combination of ASA and extended-release dipyridamole 
      increases QALYs and reduces lifetime costs compared with ASA monotherapy in
      secondary prevention of stroke. The use of ASA combined with slow-release
      dipyridamole for patients of 70 years reduces lifetime costs and adds QALYs
      compared to clopidogrel for secondary prevention of stroke. Anticoagulation
      therapy with warfarin has lower expected costs and higher expected QALYs compared
      with ASA therapy for stroke patients with atrial fibrillation.
CI  - Copyright (c)2010 by The Norwegian Institute of Public Health (NIPH).
FAU - Wisloff, Torbjorn
AU  - Wisloff T
FAU - Hamidi, Vida
AU  - Hamidi V
FAU - Ringerike, Tove
AU  - Ringerike T
FAU - Harboe, Ingrid
AU  - Harboe I
FAU - Klemp, Marianne
AU  - Klemp M
LA  - eng
PT  - Review
PT  - Book
PL  - Oslo, Norway
OTO - NOTNLM
OT  - Technology Assessment, Biomedical
OT  - Stroke
OT  - Secondary Prevention
OT  - Administration, Intravenous
OT  - Thrombolytic Therapy
OT  - Aspirin
OT  - Dipyridamole
OT  - clopidogrel
OT  - Warfarin
OT  - Pharmaceutical Preparations
OT  - Economics, Pharmaceutical
OT  - Economics, Medical
OT  - Cost-Benefit Analysis
EDAT- 2018/01/11 06:01
MHDA- 2018/01/11 06:01
CDAT- 2018/01/11 06:01
AID - NBK464882 [bookaccession]


PMID- 28230941
STAT- Publisher
DA  - 20170224
PB  - National Institute for Health and Care Excellence (NICE)
CTI - NICE Citizens Council Reports
DP  - 2010 May 22
BTI - The Use of Incentives to Improve Health
AB  - The Citizens Council provides NICE with a public perspective on overarching moral
      and ethical issues that NICE should take into account when producing guidance.
      Made up of members of the public, broadly representative of the adult UK
      population, the Council operates through a "citizens' jury" style meeting, to
      explore and respond to a question set by NICE. At its May 2010 meeting, the key
      question for the Council was: "In what circumstances are incentives to promote
      individual behaviour change an acceptable way of promoting the health of the
      public?" 12 out of the 32 members present felt there were no circumstances in
      which incentives are acceptable and gave the following reasons: A lack of
      supporting evidence. The cost of incentive schemes, especially at the present
      time. Their potential for abuse. Incentives should not be needed to help people, 
      particularly adults, to make decisions. Much help is already available (e.g.
      through the benefits system, education and in primary care). Incentives are a
      reward for inappropriate behaviour. Incentives raise concerns about the "nanny
      state" Incentives are not fair to those who make the right choices unaided, yet
      receive no rewards. Incentives can have a negative effect on public opinion. The 
      remaining 20 members felt incentives would be acceptable under certain
      conditions. Their reasons were: Incentives must be tried before we can find out
      if they work! We also need to find out why they sometimes fail. When they are
      used, their outcomes should be followed up for at least three months. Incentives 
      help to show people that they are viewed as worthy of being helped. Incentives
      are best when targeted. There are groups who need special help, for example,
      pregnant smokers and obese children. Our ultimate concern is for children.
      Incentives are best when used as part of a wider package, including e.g. other
      forms of help and support, and education. The caveats were: Incentives should not
      be exchangeable for tobacco and alcohol. People seeking to join incentive schemes
      should not do so unless they have decided they really want to change. Time limits
      and safeguards are needed if private companies are involved. Incentive schemes
      should allow for the collection of evidence. Cash incentives should be last
      resort. Personal contracts should be arranged with participants. The behaviour of
      participants while taking part in the scheme should be monitored. Both groups
      offered additional suggestions to NICE. These are listed in the 'Decision time'
      section towards the end of this report.
CI  - Copyright (c) 2010 National Institute for Health and Clinical Excellence, unless 
      otherwise stated. All rights reserved.
CN  - NICE Citizens Council
LA  - eng
PT  - Book
PL  - London
OTO - NOTNLM
OT  - citizens council
OT  - citizens jury
OT  - social values
OT  - societal values
OT  - social value judgements
OT  - ethics
OT  - healthcare ethics
OT  - incentive
OT  - behaviour change
OT  - public health
OT  - health improvement
EDAT- 2017/02/24 06:01
MHDA- 2017/02/24 06:01
CDAT- 2017/02/24 06:01
AID - NBK401701 [bookaccession]


PMID- 26065050
STAT- Publisher
DA  - 20150612
PB  - Agency for Healthcare Research and Quality (US)
CTI - AHRQ Technology Assessments
DP  - 2010 Jun 7
BTI - Systematic Reviews on Selected Pharmacogenetic Tests for Cancer Treatment: CYP2D6
      for Tamoxifen in Breast Cancer, KRAS for anti-EGFR antibodies in Colorectal
      Cancer, and BCR-ABL1 for Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia
AB  - The challenges in the integration of cancer pharmacogenetics and targeted
      therapies in clinical practice should require evidence of benefit to the patients
      (a favorable balance of harms and benefits of testing), cost-effectiveness for
      the healthcare system, incorporating patient preferences, improving provider
      education, and anticipating potential ethical and social implications. It is
      possible that pharmacogenetic testing and the subsequent use of targeted
      therapies will add cost without producing clinically meaningful improvements in
      patient outcomes. In the absence of data that can address its clinical utility
      and value, integration of pharmacogenetic testing in the healthcare system is not
      straightforward. This Technology Assessment assesses the evidence on the benefits
      and harms of three pharmacogenetic tests employed for three different diseases
      pertinent to the Medicare beneficiary population: variations in CYP2D6 and
      response to tamoxifen in breast cancer; variations in KRAS and response to
      cetuximab and panitumumab in colorectal cancer and variations in BCR-ABL1 and
      response to imatinib, dasatinib and nilotinib in chronic myeloid leukemia. The
      Coverage and Analysis Group at the Centers for Medicare and Medicaid Services
      (CMS) requested this report from The Technology Assessment Program (TAP) at the
      Agency for Healthcare Research and Quality (AHRQ). AHRQ assigned this report to
      the following Evidence-based Practice Center: Tufts EPC (HHSA 290 2007 100551).
FAU - Terasawa, Teruhiko
AU  - Terasawa T
FAU - Dahabreh, Issa
AU  - Dahabreh I
FAU - Castaldi, Peter J
AU  - Castaldi PJ
FAU - Trikalinos, Thomas A
AU  - Trikalinos TA
LA  - eng
PT  - Review
PT  - Book
PL  - Rockville (MD)
EDAT- 2015/06/12 06:00
MHDA- 2015/06/12 06:00
CDAT- 2015/06/12 06:00
AID - NBK299158 [bookaccession]


PMID- 25032374
STAT- Publisher
DA  - 20140718
ISBN- 9780309149426
ISBN- 0309149428
PB  - National Academies Press (US)
DP  - 2010
BTI - Synthetic Biology Building on Nature's Inspiration: Interdisciplinary Research
      Team Summaries
AB  - Synthetic biology is an innovative and growing field that unites engineering and 
      biology. It builds on the powerful research that came about as a result of a
      recombinant DNA technology and genome sequencing. By definition, synthetic
      biology is an interdisciplinary enterprise comprising biologists of many
      specialties, engineers, physicists, computer scientists and others. It promises a
      fundamentally deeper understanding of how living systems work and the capacity to
      recreate them for medicine, public health and the environment, including
      renewable energy. NAKFI Synthetic Biology: Building a Nation's Inspiration
      discusses new foundational technologies and tools required to make biology easier
      to engineer, considers ethical issues unique to synthetic biology, explores how
      synthetic biology can lead to an understanding of the principles underlying
      natural genetic circuits and debates how synthetic biology can be used to answer 
      fundamental biological questions.
CI  - Copyright 2010 by the National Academy of Sciences. All rights reserved.
CN  - The National Academies (US)
LA  - eng
PT  - Review
PT  - Book
PL  - Washington (DC)
EDAT- 2014/07/18 06:00
MHDA- 2014/07/18 06:00
CDAT- 2014/07/18 06:00
AID - NBK220140 [bookaccession]
AID - 10.17226/12836 [doi]


PMID- 24983055
STAT- Publisher
DA  - 20140702
ISBN- 09780309162166
ISBN- 0309162165
PB  - National Academies Press (US)
DP  - 2010
BTI - Direct-To-Consumer Genetic Testing: Summary of a Workshop
AB  - Today, scores of companies, primarily in the United States and Europe, are
      offering whole genome scanning services directly to the public. The proliferation
      of these companies and the services they offer demonstrate a public appetite for 
      this information and where the future of genetics may be headed; they also
      demonstrate the need for serious discussion about the regulatory environment,
      patient privacy, and other policy implications of direct-to-consumer (DTC)
      genetic testing. Rapid advances in genetic research already have begun to
      transform clinical practice and our understanding of disease progression.
      Existing research has revealed a genetic basis or component for numerous
      diseases, including Parkinson's disease, Alzheimer's disease, diabetes, heart
      disease, and several forms of cancer. The availability of the human genome
      sequence and the HapMap, plummeting costs of high-throughput screening, and
      increasingly sophisticated computational analyses have led to an explosion of
      discoveries of linkages between patterns of genetic variation and disease
      susceptibility. While this research is by no means a straight path toward better 
      public health, improved knowledge of the genetic linkages has the potential to
      change fundamentally the way health professionals and public health practitioners
      approach the prevention and treatment of disease. Realizing this potential will
      require greater sophistication in the interpretation of genetic tests, new
      training for physicians and other diagnosticians, and new approaches to
      communicating findings to the public. As this rapidly growing field matures, all 
      of these questions require attention from a variety of perspectives. To discuss
      some of the foregoing issues, several units of the National Academies held a
      workshop on August 31 and September 1, 2009, to bring together a still-developing
      community of professionals from a variety of relevant disciplines, to educate the
      public and policy-makers about this emerging field, and to identify issues for
      future study. The meeting featured several invited presentations and discussions 
      on the many technical, legal, policy, and ethical questions that such DTC testing
      raises, including: (1) overview of the current state of knowledge and the future 
      research trajectory; (2) shared genes and emerging issues in privacy; (3) the
      regulatory framework; and (4) education of the public and the medical community.
CI  - Copyright 2011 by the National Academy of Sciences. All rights reserved.
CN  - National Research Council (US) and Institute of Medicine (US) Roundtable on
      Translating Genomic-Based Research for Health
LA  - eng
PT  - Review
PT  - Book
PL  - Washington (DC)
EDAT- 2014/07/02 06:00
MHDA- 2014/07/02 06:00
CDAT- 2014/07/02 06:00
AID - NBK209643 [bookaccession]
AID - 10.17226/13021 [doi]


PMID- 24983038
STAT- Publisher
DA  - 20140702
PB  - National Academies Press (US)
DP  - 2010
BTI - Ethical Issues in Studying the Safety of Approved Drugs: A Letter Report
AB  - The FDA requested that the IOM examine the ethical and informed consent issues
      that should be considered when conducting clinical trials to evaluate drug
      safety. This report outlines when and how the FDA should conduct clinical trials 
      to protect the public's health and the health of trial participants.
CI  - Copyright 2010 by the National Academy of Sciences. All rights reserved.
CN  - Institute of Medicine (US) Committee on Ethical and Scientific Issues in Studying
      the Safety of Approved Drugs
LA  - eng
PT  - Review
PT  - Book
PL  - Washington (DC)
EDAT- 2014/07/02 06:00
MHDA- 2014/07/02 06:00
CDAT- 2014/07/02 06:00
AID - NBK209932 [bookaccession]
AID - 10.17226/12948 [doi]


PMID- 24983031
STAT- Publisher
DA  - 20140702
ISBN- 9780309156004
ISBN- 0309156009
PB  - National Academies Press (US)
DP  - 2010
BTI - Final Report of the National Academies' Human Embryonic Stem Cell Research
      Advisory Committee and 2010 Amendments to the National Academies' Guidelines for 
      Human Embryonic Stem Cell Research
AB  - In 2005, the National Academies released the book, Guidelines for Human Embryonic
      Stem Cell Research, which offered a common set of ethical standards for a field
      that, due to the absence of comprehensive federal funding, was lacking national
      standards for research. In order to keep the Guidelines up to date, given the
      rapid pace of scientific and policy developments in the field of stem cell
      research, the Human Embryonic Stem Cell Research Advisory Committee was
      established in 2006 with support from The Ellison Medical Foundation, The
      Greenwall Foundation, and the Howard Hughes Medical Institute. As it did in 2007 
      and 2008, the Committee identified issues that warranted revision, and this book 
      addresses those issues in a third and final set of amendments. Specifically, this
      book sets out an updated version of the National Academies' Guidelines, one that 
      takes into account the new, expanded role of the NIH in overseeing hES cell
      research. It also identifies those avenues of continuing National Academies'
      involvement deemed most valuable by the research community and other significant 
      stakeholders.
CI  - Copyright 2010 by the National Academy of Sciences. All rights reserved.
CN  - National Research Council (US) and Institute of Medicine (US) Human Embryonic
      Stem Cell Research Advisory Committee
LA  - eng
PT  - Review
PT  - Book
PL  - Washington (DC)
EDAT- 2014/07/02 06:00
MHDA- 2014/07/02 06:00
CDAT- 2014/07/02 06:00
AID - NBK210068 [bookaccession]
AID - 10.17226/12923 [doi]


PMID- 24273622
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1874-5490 (Print)
IS  - 1874-5490 (Linking)
VI  - 6
DP  - 2013
TI  - Did My Brain Implant Make Me Do It? Questions Raised by DBS Regarding
      Psychological Continuity, Responsibility for Action and Mental Competence.
PG  - 527-539
AB  - Deep brain stimulation (DBS) is a well-accepted treatment for movement disorders 
      and is currently explored as a treatment option for various neurological and
      psychiatric disorders. Several case studies suggest that DBS may, in some
      patients, influence mental states critical to personality to such an extent that 
      it affects an individual's personal identity, i.e. the experience of
      psychological continuity, of persisting through time as the same person. Without 
      questioning the usefulness of DBS as a treatment option for various serious and
      treatment refractory conditions, the potential of disruptions of psychological
      continuity raises a number of ethical and legal questions. An important question 
      is that of legal responsibility if DBS induced changes in a patient's personality
      result in damage caused by undesirable or even deviant behavior. Disruptions in
      psychological continuity can in some cases also have an effect on an individual's
      mental competence. This capacity is necessary in order to obtain informed consent
      to start, continue or stop treatment, and it is therefore not only important from
      an ethical point of view but also has legal consequences. Taking the existing
      literature and the Dutch legal system as a starting point, the present paper
      discusses the implications of DBS induced disruptions in psychological continuity
      for a patient's responsibility for action and competence of decision and raises a
      number of questions that need further research.
FAU - Klaming, Laura
AU  - Klaming L
AD  - Tilburg Institute for Law, Technology, and Society, Tilburg University, P. O. Box
      90153, 5000 LE Tilburg, The Netherlands.
FAU - Haselager, Pim
AU  - Haselager P
LA  - eng
PT  - Journal Article
DEP - 20100916
PL  - Netherlands
TA  - Neuroethics
JT  - Neuroethics
JID - 101468977
PMC - PMC3825573
OTO - NOTNLM
OT  - Deep brain stimulation
OT  - Mental competence
OT  - Personal identity
OT  - Psychological continuity
OT  - Responsibility for action
EDAT- 2013/11/26 06:00
MHDA- 2013/11/26 06:01
CRDT- 2013/11/26 06:00
PHST- 2010/04/29 00:00 [received]
PHST- 2010/09/07 00:00 [accepted]
PHST- 2013/11/26 06:00 [entrez]
PHST- 2013/11/26 06:00 [pubmed]
PHST- 2013/11/26 06:01 [medline]
AID - 10.1007/s12152-010-9093-1 [doi]
AID - 9093 [pii]
PST - ppublish
SO  - Neuroethics. 2013;6:527-539. doi: 10.1007/s12152-010-9093-1. Epub 2010 Sep 16.


PMID- 23823168
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140607
LR  - 20130704
IS  - 0963-6625 (Print)
IS  - 0963-6625 (Linking)
VI  - 21
IP  - 5
DP  - 2012 Jul
TI  - Stakeholder perspectives and reactions to "academic" cognitive enhancement:
      Unsuspected meaning of ambivalence and analogies.
PG  - 606-25
LID - 10.1177/0963662510385062 [doi]
AB  - The existence of diverging discourses in the media and academia on the use of
      prescription medications to improve cognition in healthy individuals, i.e.
      "cognitive enhancement" (CE) creates the need to better understand perspectives
      from stakeholders. This qualitative focus-group study examined perspectives from 
      students, parents and healthcare providers on CE. Stakeholders expressed
      ambivalence regarding CE (i.e. reactions to, definitions of, risks, and
      benefits). They were reluctant to adopt analogies to performance-enhancing
      steroids and caffeine though these analogies were useful in discussing concepts
      common to the use of different performance-enhancing substances. Media coverage
      of CE was criticized for lack of scientific rigor, ethical clarity, and
      inadvertent promotion of CE. Ambivalence of stakeholders suggests fundamental
      discomfort with economic and social driving forces of CE. Forms of public
      dialogue that voice the unease and ambivalence of stakeholders should be pursued 
      to avoid opting hastily for permissive or restrictive health policies for CE.
FAU - Forlini, Cynthia
AU  - Forlini C
AD  - IRCM, Canada.
FAU - Racine, Eric
AU  - Racine E
LA  - eng
PT  - Journal Article
DEP - 20101205
PL  - England
TA  - Public Underst Sci
JT  - Public understanding of science (Bristol, England)
JID - 9306503
OTO - NOTNLM
OT  - ambivalence
OT  - cognitive enhancement
OT  - focus groups
OT  - media coverage
OT  - neuroethics
OT  - stakeholder perspective
EDAT- 2013/07/05 06:00
MHDA- 2013/07/05 06:01
CRDT- 2013/07/05 06:00
PHST- 2013/07/05 06:00 [entrez]
PHST- 2013/07/05 06:00 [pubmed]
PHST- 2013/07/05 06:01 [medline]
AID - 0963662510385062 [pii]
AID - 10.1177/0963662510385062 [doi]
PST - ppublish
SO  - Public Underst Sci. 2012 Jul;21(5):606-25. doi: 10.1177/0963662510385062. Epub
      2010 Dec 5.


PMID- 22563348
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220321
IS  - 1745-8552 (Print)
IS  - 1745-8552 (Linking)
VI  - 6
IP  - 2
DP  - 2011 Jun
TI  - Creating the 'ethics industry': Mary Warnock, in vitro fertilization and the
      history of bioethics in Britain.
PG  - 121-141
AB  - Recent decades have seen a shift in the management and discussion of biomedicine.
      Issues once considered by doctors and scientists are now handled by a diverse
      array of participants, including philosophers, lawyers, theologians and lay
      representatives. This new approach, known as 'bioethics', has become the norm in 
      regulatory committees and public debate. In this article, I argue that bioethics 
      emerged as a valued enterprise in Britain during the 1980s because it fulfilled, 
      and linked, the concerns of several groups. My analysis centres on the moral
      philosopher Mary Warnock, who chaired a government inquiry into human
      fertilization and embryology between 1982 and 1984, and became a strong advocate 
      of bioethics. I detail how Warnock's promotion of bioethics tallied with the
      Conservative government's desire for increased surveillance of hitherto
      autonomous professions - while fulfilling her own belief that philosophers should
      engage in public affairs. And I also show that Warnock simultaneously promoted
      bioethics to doctors and scientists as an essential safeguard against declining
      political and public trust. This stance, I argue, framed bioethics as a vital
      intermediary between politics, the public, and biomedicine, and explains the
      growth and endurance of what the Guardian identified as an ethics industry.
FAU - Wilson, Duncan
AU  - Wilson D
AD  - Centre for History of Science, Technology and Medicine, University of Manchester 
      , UK . E-mail: duncan.wilson@manchester.ac.uk.
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
DEP - 20101129
PL  - England
TA  - Biosocieties
JT  - BioSocieties
JID - 101475169
PMC - PMC3342788
EDAT- 2012/05/09 06:00
MHDA- 2012/05/09 06:01
CRDT- 2012/05/08 06:00
PHST- 2012/05/08 06:00 [entrez]
PHST- 2012/05/09 06:00 [pubmed]
PHST- 2012/05/09 06:01 [medline]
AID - 10.1057/biosoc.2010.26 [doi]
PST - ppublish
SO  - Biosocieties. 2011 Jun;6(2):121-141. doi: 10.1057/biosoc.2010.26. Epub 2010 Nov
      29.


PMID- 22507413
OWN - NLM
STAT- MEDLINE
DCOM- 20120816
LR  - 20220318
IS  - 1445-2197 (Electronic)
IS  - 1445-1433 (Linking)
VI  - 81
IP  - 12
DP  - 2011 Dec
TI  - Fresh frozen cadavers in surgical teaching: a gelatine arterial infusion
      technique.
PG  - 880-2
LID - 10.1111/j.1445-2197.2010.05596.x [doi]
AB  - BACKGROUND: Fresh frozen human cadavers have been used at the Clinical Training
      and Evaluation Centre, The University of Western Australia, Perth, WA for years
      and are an excellent model for surgical dissection thanks to their representative
      tissue quality. Differentiation between artery and vein can be difficult as both 
      collapse post mortem. A historical technique was therefore refined to increase
      arterial rigidity using gelatine prior to freezing. METHODS: Two fresh human
      cadavers were selected after ethical approval. Gelatine was infused into the
      carotid artery in one, and into the common femoral artery in the second at a more
      dilute concentration. In both cases, infusion continued until the rate slowed
      spontaneously indicating filling prior to setting. The cadavers were frozen
      according to our standard policy and thawed for a teaching course. RESULTS: These
      were observational. Examination by palpation and dissection after freezing and
      subsequent thawing revealed arterial turgor to have developed at the popliteal
      and brachial levels in the first cadaver, and to the distal vessels in the
      second. Arterial/venous discrimination was therefore enhanced and confirmed by
      participant feedback on subsequent courses. CONCLUSION: The fresh frozen cadaver 
      is already a superior model for teaching thanks to its near life-like
      representation of tissue quality and handling. A successful technique for
      infusion of gelatine into the arterial tree of fresh human cadavers prior to
      freezing has been refined resulting in enhancement of arterial/venous
      discrimination during anatomical, interventional and surgical teaching, further
      optimizing its use in teaching and this now our standard means of preparation.
CI  - (c) 2010 The Authors. ANZ Journal of Surgery (c) 2010 Royal Australasian College 
      of Surgeons.
FAU - Jansen, Shirley
AU  - Jansen S
AD  - Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.
      sjjansen@doctors.org.uk
FAU - Kirk, Darryl
AU  - Kirk D
FAU - Tuppin, Kristie
AU  - Tuppin K
FAU - Cowie, Margaret
AU  - Cowie M
FAU - Bharadwaj, Avinash
AU  - Bharadwaj A
FAU - Hamdorf, Jeffrey M
AU  - Hamdorf JM
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20101223
PL  - Australia
TA  - ANZ J Surg
JT  - ANZ journal of surgery
JID - 101086634
RN  - 9000-70-8 (Gelatin)
SB  - IM
MH  - Arteries/*anatomy & histology/surgery
MH  - *Cadaver
MH  - *Cryopreservation
MH  - Female
MH  - Gelatin/*administration & dosage
MH  - General Surgery/*education
MH  - Humans
MH  - *Infusions, Intra-Arterial
MH  - Male
EDAT- 2012/04/18 06:00
MHDA- 2012/08/17 06:00
CRDT- 2012/04/18 06:00
PHST- 2012/04/18 06:00 [entrez]
PHST- 2012/04/18 06:00 [pubmed]
PHST- 2012/08/17 06:00 [medline]
AID - 10.1111/j.1445-2197.2010.05596.x [doi]
PST - ppublish
SO  - ANZ J Surg. 2011 Dec;81(12):880-2. doi: 10.1111/j.1445-2197.2010.05596.x. Epub
      2010 Dec 23.


PMID- 22145551
OWN - NLM
STAT- MEDLINE
DCOM- 20111229
LR  - 20170203
IS  - 0723-1393 (Print)
IS  - 0723-1393 (Linking)
VI  - 29
IP  - 4
DP  - 2010 Dec
TI  - Interpreting the declaration of Helsinki (2008): "must", "should" and different
      kinds of obligation.
PG  - 565-91
AB  - The Declaration of Helsinki is widely regarded as the preeminent code of research
      ethics. Revised six times since 1964, the versions differ in their substantive
      requirements, and also in the way that obligations are expressed, especially
      regarding the use of the prescriptors "should" and "must". The 2000 version
      contained roughly two-thirds "should" versus one-third " must". But this ratio
      was inversed in the final 2008 version--although in its penultimate draft
      practically all occurrences of "must" had been replaced with "should". We
      consider and analyze the significance of these variations for policy and
      practice. We argue that the Declaration can plausibly be viewed as 'soft law'. In
      interpreting it in legislative and jurisdictional contexts the terms "should" and
      "must" cannot be seen as synonymous. Even if the soft-law claim is rejected, and 
      the Declaration is viewed as providing ethical guidance only, the question of how
      to interpret "should" and "must" remains. We explore three possible
      interpretations: categorical versus hypothetical requirements; perfect versus
      imperfect obligations; and aspiration versus obligation. We conclude that the
      most plausible way of understanding the distinction is in relation to the
      strength of the categorical obligations which the Declaration seeks to set out.
FAU - Schmidt, H
AU  - Schmidt H
AD  - LSE Health, Nuffield Council on Bioethics, London, UK. h.t.schmidt@lse.ac.uk
FAU - Mehring, S
AU  - Mehring S
FAU - McMillan, J
AU  - McMillan J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Law
JT  - Medicine and law
JID - 8218185
SB  - IM
MH  - *Ethics, Research
MH  - *Helsinki Declaration
MH  - Human Experimentation/*legislation & jurisprudence
MH  - Humans
MH  - *Terminology as Topic
EDAT- 2011/12/08 06:00
MHDA- 2011/12/30 06:00
CRDT- 2011/12/08 06:00
PHST- 2011/12/08 06:00 [entrez]
PHST- 2011/12/08 06:00 [pubmed]
PHST- 2011/12/30 06:00 [medline]
PST - ppublish
SO  - Med Law. 2010 Dec;29(4):565-91.


PMID- 22145550
OWN - NLM
STAT- MEDLINE
DCOM- 20111229
LR  - 20170203
IS  - 0723-1393 (Print)
IS  - 0723-1393 (Linking)
VI  - 29
IP  - 4
DP  - 2010 Dec
TI  - Attitudes towards academic cheating during nursing studies.
PG  - 547-63
AB  - Nursing Student cheating is a cause for concern. Research to examine the
      attitudes of nursing students to academic cheating and what this may predict for 
      their professional practice after graduation was conducted. A convenience sample 
      of 228 students found a strong tendency to see academic dishonesty as normative. 
      The most compelling factor in the decision to plagiarize or not is the 'survival 
      instinct'. This does not necessarily mean that the student perceives copying as
      ethical. Correlations were found between personal characteristics and attitude
      towards cheating. It is recommended: (a) To raise awareness of the frequency of
      academic dishonesty and its implications for professional malpractice. (b) To
      institute a policy promoting academic integrity by ensuring all involved,
      including the students become partners in rule enforcement. (c) To establish a
      policy of penalties sufficiently strong to deter all, students and staff, from
      dishonest practices.
FAU - Balik, C
AU  - Balik C
AD  - Shenbrun Academic Nursing School, Tel- Aviv Medical Center.
      Chayab@tasmc.health.gov.il
FAU - Sharon, D
AU  - Sharon D
FAU - Kelishek, S
AU  - Kelishek S
FAU - Tabak, N
AU  - Tabak N
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Law
JT  - Medicine and law
JID - 8218185
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - *Deception
MH  - Ethics, Nursing
MH  - Female
MH  - Humans
MH  - Israel
MH  - Male
MH  - Organizational Policy
MH  - Punishment
MH  - Sampling Studies
MH  - *Students, Nursing
EDAT- 2011/12/08 06:00
MHDA- 2011/12/30 06:00
CRDT- 2011/12/08 06:00
PHST- 2011/12/08 06:00 [entrez]
PHST- 2011/12/08 06:00 [pubmed]
PHST- 2011/12/30 06:00 [medline]
PST - ppublish
SO  - Med Law. 2010 Dec;29(4):547-63.


PMID- 22145549
OWN - NLM
STAT- MEDLINE
DCOM- 20111229
LR  - 20170203
IS  - 0723-1393 (Print)
IS  - 0723-1393 (Linking)
VI  - 29
IP  - 4
DP  - 2010 Dec
TI  - The place for emotions in professional carers' thinking: reflections on two
      cases.
PG  - 537-46
AB  - How do carers know what is right for their patient? What can they do further to
      relying on the two pillars of knowledge and ethics? Knowledge foregrounds
      rational decision-making based on scientific evidence. It allows cost-benefit
      rationalization and the choice of the best feasible objective. The steady advance
      of medical science drives responsible carers to keep their knowledge and skills
      up-to-date. Bioethics grants primary attention to the prevention of causing harm 
      in general, to pursuant of patients' subjective wellbeing and to allow the latter
      enjoy their autonomy and to guarantee them the sense of justice. There are,
      however, cases where these values collide and any care decision violates one
      principle or another. How are carers expected to act then? This article concerns 
      the choices made by carers, as presented and discussed in two cases. These cases 
      deal with a clash between two principles: parenthood vs. fertility, religious
      rite vs. social affiliation. This class has generated an ethical dilemma. In each
      case carers try to justify their choices by expert knowledge and other ethical
      values, but later reflection reveals that the predominant element in 'solving'
      these dilemmas was "emotions." Professional training submits that: 'Set aside
      feelings in order to keep your thinking 'straight.' However, reality proves this 
      simply infeasible. The more complex the medical-ethical situation, it is more
      likely that "emotions" take over. We have no choice as responsible carers but to 
      allow our emotions the status of a factor of influence in their own right.
      Nowadays, a basic medical training for doctors and nurses offers an integrated
      body of knowledge and therapeutic skills. In addition, trainees are introduced to
      bioethics, supposedly sufficient to guide their future steps in their chosen
      profession. But how does this training in fact shape their future ethical
      conduct, if at all? How does it affect their ability to maintain ethical
      responsibility throughout therapeutic interactions? Perhaps there are other
      factors which govern the individual's conduct and his/her ethical responsibility?
      Simulation exercises were conducted, designed to induce healthcare professionals 
      to reflect on the ethics of their own decision-making. The results demonstrated
      that therapeutic skills and familiarity with bioethical principles are not the
      sole factors governing the individual's ethical conduct. It turns out that
      emotions and feelings play a key part; this at once raises the question as to
      whether a medical training for doctors and nurses, in its current format,
      concerns itself with emotions and with how emotions shape a therapeutic
      personality. If not, then our training designers have food for thought. How can
      such training make trainees more aware of the power of their emotions? And, what 
      are the ramifications on daily practice concerning ethical responsibility?
      Another question concerns the possible proper methods for mastering the
      theoretical materials and the practical techniques that promote emotional
      self-development?
FAU - Koren, E
AU  - Koren E
AD  - Nursing Division, The Israeli Ministry of Health, Jerusalem. ellakoren@gmail.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Law
JT  - Medicine and law
JID - 8218185
SB  - IM
MH  - *Bioethical Issues
MH  - Emotions
MH  - *Empathy
MH  - Humans
MH  - Judgment
MH  - *Professional-Patient Relations
MH  - *Social Values
EDAT- 2011/12/08 06:00
MHDA- 2011/12/30 06:00
CRDT- 2011/12/08 06:00
PHST- 2011/12/08 06:00 [entrez]
PHST- 2011/12/08 06:00 [pubmed]
PHST- 2011/12/30 06:00 [medline]
PST - ppublish
SO  - Med Law. 2010 Dec;29(4):537-46.


PMID- 22145547
OWN - NLM
STAT- MEDLINE
DCOM- 20111229
LR  - 20181201
IS  - 0723-1393 (Print)
IS  - 0723-1393 (Linking)
VI  - 29
IP  - 4
DP  - 2010 Dec
TI  - Inadequate treatment of pain: time for the South African courts to redress this
      human rights violation?
PG  - 497-522
AB  - In the case of 90 per cent of patients, pain can be relieved adequately, but in
      80 per cent of these cases this is not done, despite the fact that effective pain
      medication is available. More than three decades ago, the under-treatment of pain
      had already been identified as a major global problem. Human dignity requires
      that treatable pain be relieved. Although attempts have been made to address this
      unnecessary human suffering, there are a number of reasons why little progress
      has been made. Fear of the regulatory authority has been mentioned, but in South 
      Africa this is not the case. A lack of knowledge and archaic views have resulted 
      in the standard practice of mismanaging pain. Diverging views on whether the
      health care system's failure to treat patient pain adequately needs corrective
      action by the judiciary will be discussed. An argument will be made out that the 
      courts should reconsider the standard practice and the question of what is
      reasonable in regard to pain treatment. The "failure to treat pain adequately"
      should be recognised as a separate and independent form of medical negligence.
      Other possible causes of action will also be discussed. Improvements in pain
      management require simultaneous initiatives in medicine, law and ethics.
FAU - Jansen, Rita-Marie
AU  - Jansen RM
AD  - Faculty of Law, University of the Free State, Bloemfontein, South Africa.
      jansenr@ufs.ac.za
LA  - eng
PT  - Journal Article
PT  - Legal Case
PL  - United States
TA  - Med Law
JT  - Medicine and law
JID - 8218185
SB  - IM
MH  - Human Rights/*legislation & jurisprudence
MH  - Humans
MH  - Liability, Legal
MH  - Malpractice/legislation & jurisprudence
MH  - *Pain Management
MH  - South Africa
MH  - Terminally Ill
EDAT- 2011/12/08 06:00
MHDA- 2011/12/30 06:00
CRDT- 2011/12/08 06:00
PHST- 2011/12/08 06:00 [entrez]
PHST- 2011/12/08 06:00 [pubmed]
PHST- 2011/12/30 06:00 [medline]
PST - ppublish
SO  - Med Law. 2010 Dec;29(4):497-522.


PMID- 22145545
OWN - NLM
STAT- MEDLINE
DCOM- 20111229
LR  - 20170203
IS  - 0723-1393 (Print)
IS  - 0723-1393 (Linking)
VI  - 29
IP  - 4
DP  - 2010 Dec
TI  - The traceability of carcinogenic occupational risks: state of progress in France 
      compared with other European countries.
PG  - 467-86
AB  - Occupational risks are constantly evolving. The complexification of these
      occupational risks, the context of the flexibility with the new forms of
      organization, the new conditions of use and the increase in occupational mobility
      are accentuating the difficulties of assessment of the deferred risks for the
      health of employees. In point of fact, if on the one hand the immediate risk
      (accidental, corrosive, caustic, explosive...) is properly taken into account, on
      the other hand this is far from the case for the deferred risk, in particular the
      carcinogenic risk. Now, the liability of employers (especially with regard to
      cancers due to asbestos) is incurred more and more often. It is they in fact who 
      bear the brunt of the prevention of occupational risks in France. Since 2002, the
      French employer has thus a veritable safety performance obligation in terms of
      preserving the health of the employees. Now, one of the vital keys to the
      prevention of deferred occupational risks resides in the traceability of the
      exposures that the employees have undergone throughout their working lives, in
      particular carcinogenic. In this context, the follow-up of the exposure of the
      employees to carcinogenic risks then becomes a necessity. The awareness of the
      necessity of setting in place an occupational exposure follow-up tool is not
      recent. Traceability procedures exist moreover in a certain number of countries, 
      but so far in France we have only seen ad hoc experiments of a very limited
      nature for the identification and storage of occupational exposure. These are not
      of an exhaustive nature or only relate to mainly medical data. There is no
      systematic tool for the follow-up of carcinogenic exposure. This is due, on the
      one hand to the technical difficulties of setting in place standardized tools for
      exposure data collation, and on the other hand to the fact that the traceability 
      of the personal information collated may raise ethical issues of reconciling the 
      right to health of the employees with their right to work and the observing of
      their individual liberties; lastly, because the amassing of such information may 
      raise issues of liability, in particular for the employer exposing its employees 
      to carcinogens. Such issues transcend frontiers and have to be taken into
      consideration in order for progress to be made in the area of traceability of
      occupational exposure. Very few studies have been devoted to this subject so
      crucial to the prevention of occupational diseases. We propose, initially, to
      define traceability and the issues involved. Next, we will consider the current
      regulatory obligations on employers in France that may contribute to the
      traceability of occupational exposure and their limits. Then we will examine the 
      brakes--the legal, ethical and technical difficulties that explain why France is 
      lagging behind in this field. Finally, we will study the French perspectives with
      regard to the European advances in the traceability area.
FAU - Fantoni-Quinton, S
AU  - Fantoni-Quinton S
AD  - Universite Lille Nord de France--UDSL, CRD&P--LEREDS. fanquin@wanadoo.fr
FAU - Frimat, P
AU  - Frimat P
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Law
JT  - Medicine and law
JID - 8218185
RN  - 0 (Carcinogens)
SB  - IM
MH  - Carcinogens/*toxicity
MH  - Compensation and Redress/legislation & jurisprudence
MH  - France
MH  - Humans
MH  - Neoplasms/chemically induced/epidemiology
MH  - Occupational Diseases/chemically induced/epidemiology
MH  - Occupational Exposure/*adverse effects/*legislation & jurisprudence
MH  - Occupational Health/*legislation & jurisprudence
EDAT- 2011/12/08 06:00
MHDA- 2011/12/30 06:00
CRDT- 2011/12/08 06:00
PHST- 2011/12/08 06:00 [entrez]
PHST- 2011/12/08 06:00 [pubmed]
PHST- 2011/12/30 06:00 [medline]
PST - ppublish
SO  - Med Law. 2010 Dec;29(4):467-86.


PMID- 22131863
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1918-1485 (Electronic)
IS  - 1205-7088 (Linking)
VI  - 15
IP  - 10
DP  - 2010 Dec
TI  - Parents' compliance with specific medical instructions in newborn discharge
      letters.
PG  - 649-53
AB  - BACKGROUND: Due to decreased hospital stay, follow-up of unresolved medical
      problems of babies with uncomplicated postpartum course is relegated to
      outpatient clinics. OBJECTIVE: To identify factors in discharge letters that
      influence parent compliance. METHODS: Telephone contact with parents three months
      after discharge queried compliance with routine and special instructions as
      written in discharge letters. Statistical analyses compared responses of
      compliant versus less compliant parents. P<0.05 was considered to be
      statistically significant. The present study was approved by the Institutional
      Ethical Review Board Committee. RESULTS: Of the 2000 discharge letters, 319 (16%)
      included special instructions. Parents of 252 infants (79%) who received
      discharge letters containing 332 special instructions were interviewed by
      telephone. Compliance was greater for noninvasive instructions (86%) relative to 
      others (57.8%) (P<0.001). Initiation of follow-up visits was correlated with
      parity (P<0.001) and maternal age (P<0.001). CONCLUSION: Discharge letters should
      be read and discussed with parents before infants are discharged, and the
      relevance of specific medical instructions should be emphasized.
FAU - Schimmel, Michael S
AU  - Schimmel MS
AD  - Department of Neonatology, Shaare Zedek Medical Center, and Faculty of Health,
      The Hebrew University of Jerusalem, Jerusalem;
FAU - Wasserteil, Netanel
AU  - Wasserteil N
FAU - Perry, Zvi H
AU  - Perry ZH
FAU - Erlichman, Matti
AU  - Erlichman M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Paediatr Child Health
JT  - Paediatrics & child health
JID - 9815960
PMC - PMC3006214
OTO - NOTNLM
OT  - Discharge
OT  - Follow-up study
OT  - Health care survey
OT  - Health information
OT  - Newborn
EDAT- 2011/12/02 06:00
MHDA- 2011/12/02 06:01
CRDT- 2011/12/02 06:00
PHST- 2009/10/05 00:00 [accepted]
PHST- 2011/12/02 06:00 [entrez]
PHST- 2011/12/02 06:00 [pubmed]
PHST- 2011/12/02 06:01 [medline]
AID - 10.1093/pch/15.10.649 [doi]
PST - ppublish
SO  - Paediatr Child Health. 2010 Dec;15(10):649-53. doi: 10.1093/pch/15.10.649.


PMID- 22112494
OWN - NLM
STAT- MEDLINE
DCOM- 20120712
LR  - 20211021
IS  - 1875-8592 (Electronic)
IS  - 1574-0153 (Linking)
VI  - 9
IP  - 1-6
DP  - 2010
TI  - Issues in collecting, processing and storing human tissues and associated
      information to support biomedical research.
PG  - 531-49
LID - 10.3233/CBM-2011-0183 [doi]
AB  - The availability of human tissues to support biomedical research is critical to
      advance translational research focused on identifying and characterizing
      approaches to individualized (personalized) medical care. Providing such tissues 
      relies on three acceptable models - a tissue banking model, a prospective
      collection model and a combination of these two models. An unacceptable model is 
      the "catch as catch can" model in which tissues are collected, processed and
      stored without goals or a plan or without standard operating procedures, i.e.,
      portions of tissues are collected as available and processed and stored when time
      permits. In the tissue banking model, aliquots of tissues are collected according
      to SOPs. Usually specific sizes and types of tissues are collected and processed 
      (e.g., 0.1 gm of breast cancer frozen in OCT). Using the banking model, tissues
      may be collected that may not be used and/or do not meet specific needs of
      investigators; however, at the time of an investigator request, tissues are
      readily available as is clinical information including clinical outcomes. In the 
      model of prospective collection, tissues are collected based upon investigator
      requests including specific requirements of investigators. For example, the
      investigator may request that two 0.15 gm matching aliquots of breast cancer be
      minced while fresh, put in RPMI media with and without fetal calf serum, cooled
      to 4 degrees C and shipped to the investigator on wet ice. Thus, the tissues
      collected prospectively meet investigator needs, all collected specimens are
      utilized and storage of specimens is minimized; however, investigators must wait 
      until specimens are collected, and if needed, for clinical outcome. The operation
      of any tissue repository requires well trained and dedicated personnel. A quality
      assurance program is required which provides quality control information on the
      diagnosis of a specimen that is matched specifically to the specimen provided to 
      an investigator instead of an overall diagnosis of the specimen via a surgical
      pathology report. This is necessary because a specific specimen may not match the
      diagnosis of the case due to many factors such as necrosis, unsuspected tumor
      invasion of apparently normal tissue, and areas of fibrosis which are mistaken
      grossly for tumor. Aliquots for quality control (QC) may or may not be collected 
      at the time of collection and in some cases, QC may not occur until specimens are
      distributed to investigators. In establishing a tumor repository, multiple issues
      need to be considered. These include the available resources, long term support, 
      space and equipment. The needs of the potential users need to be identified as to
      the types of tissues and services needed and the annotation expected. Other
      specific issues to be considered include collection of specimens potentially
      infected with blood borne pathogens (e.g., hepatitis B), charge back mechanisms, 
      informatics needs and support, and investigator requirements (e.g., recognition
      of repository contributions in publications). In general, the repository should
      not perform the research of the investigators, but should provide the
      infrastructure necessary to support the research of the investigator. Thus, the
      goals of the repository must be established. Similarly, ethical and regulatory
      issues must be evaluated. In general, tissue repositories need ethical (e.g.,
      IRB) and privacy (e.g., HIPAA) review. Also, safety issues need to be considered 
      as well as how biohazards will be addressed by investigator-users. Considerations
      involving the transfer of specimens to other organization usually require a
      material transfer agreement (MTA). A MTA should address biohazards as well as
      indemnification. Thus, many issues must be considered and addressed in order to
      establish and operate successfully a biorepository.
FAU - Grizzle, William E
AU  - Grizzle WE
AD  - Division of Anatomic Pathology, Department of Pathology, University of Alabama at
      Birmingham, Birmingham, AL, USA. wgrizzle@uab.edu
FAU - Bell, Walter C
AU  - Bell WC
FAU - Sexton, Katherine C
AU  - Sexton KC
LA  - eng
GR  - 5U01CA44968/CA/NCI NIH HHS/United States
GR  - 5P30CA13148-39/CA/NCI NIH HHS/United States
GR  - P50 CA089019/CA/NCI NIH HHS/United States
GR  - P30 CA013148/CA/NCI NIH HHS/United States
GR  - P20CA101955/CA/NCI NIH HHS/United States
GR  - P50 CA101955/CA/NCI NIH HHS/United States
GR  - 5U24CA086359/CA/NCI NIH HHS/United States
GR  - P20 CA101955/CA/NCI NIH HHS/United States
GR  - U01 CA044968/CA/NCI NIH HHS/United States
GR  - P30AR50948-07/AR/NIAMS NIH HHS/United States
GR  - 5P50CA89019/CA/NCI NIH HHS/United States
GR  - U24 CA086359/CA/NCI NIH HHS/United States
GR  - P30 AR050948/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - Netherlands
TA  - Cancer Biomark
JT  - Cancer biomarkers : section A of Disease markers
JID - 101256509
SB  - IM
MH  - *Biomedical Research
MH  - Humans
MH  - *Informatics
MH  - Quality Control
MH  - Specimen Handling
MH  - *Tissue Banks/ethics/legislation & jurisprudence
PMC - PMC3445033
MID - NIHMS401633
EDAT- 2011/11/25 06:00
MHDA- 2012/07/13 06:00
CRDT- 2011/11/25 06:00
PHST- 2011/11/25 06:00 [entrez]
PHST- 2011/11/25 06:00 [pubmed]
PHST- 2012/07/13 06:00 [medline]
AID - A02428V61625Q089 [pii]
AID - 10.3233/CBM-2011-0183 [doi]
PST - ppublish
SO  - Cancer Biomark. 2010;9(1-6):531-49. doi: 10.3233/CBM-2011-0183.


PMID- 22106584
OWN - NLM
STAT- MEDLINE
DCOM- 20111223
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 7
IP  - 4
DP  - 2010 Oct-Dec
TI  - Ethics and law.
PG  - 263
FAU - Ravindran, G D
AU  - Ravindran GD
LA  - eng
PT  - Letter
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - *Ethics, Medical
MH  - Humans
MH  - India
MH  - *Jurisprudence
MH  - *Periodicals as Topic
EDAT- 2011/11/24 06:00
MHDA- 2011/12/24 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/24 06:00 [medline]
AID - 10.20529/IJME.2010.097 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2010 Oct-Dec;7(4):263. doi: 10.20529/IJME.2010.097.


PMID- 22106582
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111223
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 7
IP  - 4
DP  - 2010 Oct-Dec
TI  - Hospital ethics committees: time to move beyond the obvious.
PG  - 251-2
FAU - Khan, Robyna Irshad
AU  - Khan RI
AD  - Department of Anaesthesia, Aga Khan University, PO Box 3500, Stadium Road,
      Karachi 74800, Pakistan. robyna.khan@aku.edu
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
CON - Mayo Clin Proc. 2010 May;85(5):433-8. PMID: 20435836
EDAT- 2011/11/24 06:00
MHDA- 2011/11/24 06:01
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/11/24 06:01 [medline]
AID - 10.20529/IJME.2010.093 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2010 Oct-Dec;7(4):251-2. doi: 10.20529/IJME.2010.093.


PMID- 22106579
OWN - NLM
STAT- MEDLINE
DCOM- 20111223
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 7
IP  - 4
DP  - 2010 Oct-Dec
TI  - The Health Impact Fund: a potential solution to inequity in global drug access.
PG  - 240-3
AB  - Global health inequities persist despite significant increases in funding and a
      growing number of global health initiatives. Especially vulnerable to disease,
      the poor majority of the world's population currently cannot afford advanced
      medicines, and the diseases confined to the poor receive little attention from
      pharmaceutical research. As a complement to the existing intellectual property
      regime, we have proposed the Health Impact Fund (HIF) as a mechanism that would
      create incentives for the development and optimal promotion of new high-impact
      medicines sold at the cost of manufacture. In this article, we outline the HIF
      and its ethical significance.
FAU - Banerjee, Amitava
AU  - Banerjee A
AD  - Stroke Prevention Research Unit, University of Oxford, John Radcliffe Hospital,
      Oxford OX3 9DU, United Kingdom. amitava.banerjee@clneuro.ox.ac.uk
FAU - Pogge, Thomas
AU  - Pogge T
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Drug Discovery/economics/ethics
MH  - Drug Industry/*economics
MH  - Fees, Pharmaceutical/ethics
MH  - *Financing, Government
MH  - Global Health
MH  - Health Services Accessibility/*economics
MH  - Healthcare Disparities/ethics
MH  - Humans
MH  - *International Cooperation
MH  - Orphan Drug Production/economics/ethics
MH  - Patents as Topic/ethics/legislation & jurisprudence
MH  - Research Support as Topic/organization & administration
EDAT- 2011/11/24 06:00
MHDA- 2011/12/24 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/24 06:00 [medline]
AID - 10.20529/IJME.2010.089 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2010 Oct-Dec;7(4):240-3. doi: 10.20529/IJME.2010.089.


PMID- 22106572
OWN - NLM
STAT- MEDLINE
DCOM- 20111223
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 7
IP  - 4
DP  - 2010 Oct-Dec
TI  - Attitudes and practices of medical graduates in Delhi towards gifts from the
      pharmaceutical industry.
PG  - 223-5
AB  - Pharmaceutical companies use a variety of strategies, including gifts, to
      influence physicians. In December 2009, the Medical Council of India amended the 
      Code of Medical Ethics to ban medical professionals from accepting gifts from
      pharmaceutical companies. In view of this ban, it is important to find out the
      magnitude and contours of the problem amongst Indian medical professionals. We
      aimed to study, through an e-mail based survey, the attitudes and practices of
      young resident doctors and interns from two medical colleges of New Delhi
      regarding acceptance of gifts from the pharmaceutical industry. We e-mailed the
      questionnaire to 150 fresh graduates. We found that the majority of graduates
      agreed with existing guidelines: they accepted low cost gifts but considered
      expensive gifts unrelated to patient welfare unethical. Despite the low response 
      rate, this study is important because data from India on attitudes and practices 
      of medical professionals regarding gifts from the pharmaceutical industry are
      virtually non-existent.
FAU - Sharma, Vishal
AU  - Sharma V
AD  - University College of Medical Sciences, India. drvishal82@gmail.com
FAU - Aggarwal, Sourabh
AU  - Aggarwal S
FAU - Singh, Harkirat
AU  - Singh H
FAU - Garg, Shashank
AU  - Garg S
FAU - Sharma, Alka
AU  - Sharma A
FAU - Sharma, Rashmi
AU  - Sharma R
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Adult
MH  - Drug Industry/*ethics
MH  - Female
MH  - Gift Giving/*ethics
MH  - Health Care Surveys
MH  - Humans
MH  - India
MH  - Internship and Residency/*ethics
MH  - Male
MH  - Practice Patterns, Physicians'/*ethics
EDAT- 2011/11/24 06:00
MHDA- 2011/12/24 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/24 06:00 [medline]
AID - 10.20529/IJME.2010.082 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2010 Oct-Dec;7(4):223-5. doi: 10.20529/IJME.2010.082.


PMID- 22106571
OWN - NLM
STAT- MEDLINE
DCOM- 20111223
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 7
IP  - 4
DP  - 2010 Oct-Dec
TI  - Faculty awareness and interest about bioethics in a private medical college of
      Islamabad, Pakistan.
PG  - 220-2
AB  - This study sought to evaluate the awareness of bioethics among faculty at Shifa
      College of Medicine, Islamabad, Pakistan, and to assess their interest in
      becoming part of a bioethics discussion group and enhancing their knowledge of
      this subject. 122 faculty members from the medical college, hospital and school
      of nursing filled out a questionnaire on ethics. 53% were aware of bioethics as a
      specialty. 85% showed an interest in educating themselves further in the subject 
      and 61% were interested in becoming part of a bioethics discussion group. Only 50
      out of 122 faculty members knew what an ethical dilemma was and only 38 were able
      to describe one in detail. The awareness level of bioethics as a specialty
      increased with seniority. However the enthusiasm to join a bioethics discussion
      group was greater among those at a junior level.
FAU - Iqbal, Saima P
AU  - Iqbal SP
AD  - Department of Community Health Sciences, Shifa College of Medicine, Sector H-8/4,
      Pitras Bukhari Road, Islamabad, Pakistan. saimapi@yahoo.com
FAU - Khizar, Bushra
AU  - Khizar B
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Adult
MH  - *Education, Medical
MH  - Ethics, Medical/*education
MH  - *Faculty
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pakistan
MH  - *Staff Development
EDAT- 2011/11/24 06:00
MHDA- 2011/12/24 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/24 06:00 [medline]
AID - 10.20529/IJME.2010.081 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2010 Oct-Dec;7(4):220-2. doi: 10.20529/IJME.2010.081.


PMID- 22106570
OWN - NLM
STAT- MEDLINE
DCOM- 20111223
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 7
IP  - 4
DP  - 2010 Oct-Dec
TI  - Lessons from the response to A H1N1 influenza, 2009, India: ethics in pandemic
      planning.
PG  - 216-9
AB  - After the Severe Acute Respiratory Syndrome (SARS) experience in 2003, ethics has
      found a place in discourses on pandemic planning and public health. It is no
      longer enough to merely have action strategies in a pandemic plan; both research 
      literature and the World Health Organization recommend that one has to further
      ensure that the outcome of such action is fair to all concerned, and is in
      conformity with relevant ethical values and considerations. India's pandemic plan
      suffers from a glaring omission in this aspect. Taking strategies and responses
      during the 2009 A H1N1 outbreak in India as instances, this paper identifies the 
      lessons to be learnt from this experience and argues that these raise ethical
      issues ingrained in pandemic planning which must be addressed. It ends with the
      suggestion that the Indian health authorities should add an ethical dimension to 
      the national pandemic plan, as has been recommended by the World Health
      Organization and by post-SARS studies.
FAU - Chakraborti, Chhanda
AU  - Chakraborti C
AD  - Department of Humanities and Social Sciences, Indian Institute of Technology,
      Kharagpur, West Bengal 721 302, India. chhanda@hss.iitkgp.ernet.in
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - *Disaster Planning
MH  - Epidemics/*prevention & control
MH  - Health Planning/*ethics
MH  - Humans
MH  - India/epidemiology
MH  - *Influenza A Virus, H1N1 Subtype
MH  - Influenza, Human/*prevention & control
EDAT- 2011/11/24 06:00
MHDA- 2011/12/24 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/24 06:00 [medline]
AID - 10.20529/IJME.2010.080 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2010 Oct-Dec;7(4):216-9. doi: 10.20529/IJME.2010.080.


PMID- 22043226
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1715-6580 (Electronic)
IS  - 1715-6572 (Linking)
VI  - 6
IP  - 2
DP  - 2010 Nov
TI  - Moral Distress among Healthcare Managers: Conditions, Consequences and Potential 
      Responses.
PG  - 99-112
AB  - Moral distress - the physical and emotional response to feeling prevented from
      carrying out ethically proper action - can have serious consequences for health
      professionals and healthcare organizations. We investigated perceived moral
      distress qualitatively with managers in two BC health authorities.RESPONDENTS
      DESCRIBED CONDITIONS UNDER WHICH THEY EXPERIENCED DISTRESS: when they set
      priorities within highly resource-constrained environments, when they observed
      inequities between budget allocations and management responsibilities, and when
      organizational priorities did not align with their personal values. When coping
      proved insufficient, managers would respond by leaving positions, organizations
      or the healthcare field altogether.Respondents asked for leadership development
      and the creation of spaces in which moral distress could be openly discussed.
      However, formal training in priority setting did not appear to be helpful on its 
      own. Rather, it increased managers' awareness of the ethical dimensions of
      resource allocation without (in this instance) entrenching supports that would
      help them resolve these concerns.
FAU - Mitton, Craig
AU  - Mitton C
AD  - Senior Scientist, Centre for Clinical Epidemiology & Evaluation, Vancouver
      Coastal Health Research Institute.
FAU - Peacock, Stuart
AU  - Peacock S
FAU - Storch, Jan
AU  - Storch J
FAU - Smith, Neale
AU  - Smith N
FAU - Cornelissen, Evelyn
AU  - Cornelissen E
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Healthc Policy
JT  - Healthcare policy = Politiques de sante
JID - 101280107
PMC - PMC3016638
EDAT- 2011/11/02 06:00
MHDA- 2011/11/02 06:01
CRDT- 2011/11/02 06:00
PHST- 2011/11/02 06:00 [entrez]
PHST- 2011/11/02 06:00 [pubmed]
PHST- 2011/11/02 06:01 [medline]
PST - ppublish
SO  - Healthc Policy. 2010 Nov;6(2):99-112.


PMID- 22032021
OWN - NLM
STAT- MEDLINE
DCOM- 20111123
LR  - 20211020
IS  - 1321-2753 (Print)
IS  - 1321-2753 (Linking)
VI  - 20
IP  - 2
DP  - 2010 Sep
TI  - The acceptability among lay persons and health professionals of actively ending
      the lives of damaged newborns.
PG  - 14.1-24
AB  - BACKGROUND: Euthanasia is performed on occasion, even on newborns, but is highly 
      controversial, and it is prohibited by law and condemned by medical ethics in
      most countries. AIM: To characterise and compare the judgments of lay persons,
      nurses, and physicians of the acceptability of actively ending the life of a
      damaged newborn. METHODS: Convenience samples of 237 lay persons, 214 nurses, and
      76 physicians in the south of France rated the acceptability on a scale of 0-10
      of giving a lethal injection in 54 scenarios composed of all combinations of 4
      within-subject factors: gestational age of 6, 7, or 9 months; 3 levels of
      severity of either perinatal asphyxia or of genetic disease; attitude of the
      parents about prolonging care unknown, favourable, or unfavourable; and decision 
      made individually by the physician or collectively by the medical team. Overall
      ratings were subjected to cluster analysis and each cluster to analysis of
      variance and graphic representation. RESULTS: Lay persons (mean acceptability
      rating 4.29) were significantly more favourable to euthanasia than nurses (2.84),
      p < .005, or physicians (2.12), p < .005. Five clusters were found with different
      judgment rules, i.e., how the information was integrated. More physicians (30 per
      cent) than nurses (14 per cent), p < .01, or lay persons (11 per cent), p < .01, 
      rated euthanasia as never, under any condition, acceptable. Most, however,
      asserted that it was increasingly acceptable as the factors combined to favour
      it, especially when the parents desired to stop treatment. More physicians (45
      per cent) and nurses (46 per cent) than lay persons (21 per cent), p < .01, used 
      a complex conjunctive rule (level of parent's attitude x level of severity of
      damage x consultation with team or not) rather than a simple additive rule.
      CONCLUSIONS: Unlike law and medical ethics, most of the lay persons, nurses, and 
      physicians judged the acceptability of euthanasia as a function of the
      circumstances. Most health professionals combined the factors in a conjunctive
      (multiplicative), rather than additive, fashion in accordance with legislation
      for adults in The Netherlands and elsewhere that requires a set of criteria to be
      fulfilled before it is legitimate to end a patient's life.
FAU - Teisseyre, Nathalie
AU  - Teisseyre N
AD  - Universite du Mirail, Toulouse, France.
FAU - Vanraet, Charles
AU  - Vanraet C
FAU - Sorum, Paul C
AU  - Sorum PC
FAU - Mullet, Etienne
AU  - Mullet E
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Monash Bioeth Rev
JT  - Monash bioethics review
JID - 100973394
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Asphyxia Neonatorum
MH  - *Attitude of Health Personnel
MH  - *Attitude to Health
MH  - Cluster Analysis
MH  - Euthanasia, Active/*ethics
MH  - Female
MH  - France
MH  - Genetic Diseases, Inborn
MH  - Humans
MH  - Infant, Newborn
MH  - *Infant, Newborn, Diseases
MH  - Male
MH  - Middle Aged
MH  - Nurses
MH  - Parents
MH  - Physicians
EDAT- 2011/10/29 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/10/29 06:00
PHST- 2011/10/29 06:00 [entrez]
PHST- 2011/10/29 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/BF03351524 [doi]
PST - ppublish
SO  - Monash Bioeth Rev. 2010 Sep;20(2):14.1-24. doi: 10.1007/BF03351524.


PMID- 22032019
OWN - NLM
STAT- MEDLINE
DCOM- 20111123
LR  - 20211020
IS  - 1321-2753 (Print)
IS  - 1321-2753 (Linking)
VI  - 20
IP  - 2
DP  - 2010 Sep
TI  - Saviour siblings and collective family interests.
PG  - 12.1-15
AB  - In this article, I will explore the ethical concerns arising out of the use of
      preimplantation tissue typing (PTT) to create saviour siblings. There are two
      main ethical concerns about the welfare of the child to be born as a result of
      PTT. The first is whether the child to be born is treated as a commodity, as
      simply a means to save the life of his or her sibling. The second is whether the 
      child to be born will be harmed as a result of PTT, either physically,
      psychologically or socially. These two ethical concerns reflect an
      individualistic approach to the welfare of the child, whose interests are treated
      as largely separate to the interests of other family members. I will argue that
      the welfare of the child born as a result of PTT should be conceived more broadly
      to include not only the child's individual interests, but also the collective
      interests the child shares with his or her family. I base this broader conception
      of welfare on the notion of human flourishing, which recognises that the welfare 
      of a child is inextricably connected to the welfare of the intimate collective
      that is his or her family. The collective interests of intimate family members
      are particularly relevant in the context of PTT, as the members are engaged in a 
      shared journey to save the life of an ill child.
FAU - Taylor-Sands, Michelle
AU  - Taylor-Sands M
AD  - Melbourne Law School, The University of Melbourne. m.taylor-sands@unimelb.edu.au
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Monash Bioeth Rev
JT  - Monash bioethics review
JID - 100973394
SB  - IM
MH  - Child
MH  - Child Welfare/ethics
MH  - Commodification
MH  - Directed Tissue Donation/*ethics
MH  - Embryo Transfer/ethics
MH  - *Family Relations
MH  - Histocompatibility Testing/*ethics
MH  - Humans
MH  - Preimplantation Diagnosis/*ethics
MH  - *Siblings
MH  - Tissue Donors/ethics
EDAT- 2011/10/29 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/10/29 06:00
PHST- 2011/10/29 06:00 [entrez]
PHST- 2011/10/29 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/BF03351522 [doi]
PST - ppublish
SO  - Monash Bioeth Rev. 2010 Sep;20(2):12.1-15. doi: 10.1007/BF03351522.


PMID- 21990820
OWN - NLM
STAT- MEDLINE
DCOM- 20120906
LR  - 20111012
IS  - 1759-8486 (Electronic)
IS  - 1759-8478 (Linking)
VI  - 3
IP  - 2
DP  - 2011 Jun
TI  - The neurointerventionalist and the AdvaMed Code of Ethics: examining the
      doctor-device industry relationship.
PG  - 204-6
LID - 10.1136/jnis.2010.003921 [doi]
FAU - White, Christopher
AU  - White C
AD  - AdvaMed, Washington, DC, USA. cwhite@advamed.org
FAU - Brugera, Carolyn
AU  - Brugera C
FAU - Hirsch, Joshua
AU  - Hirsch J
LA  - eng
PT  - Journal Article
DEP - 20101119
PL  - England
TA  - J Neurointerv Surg
JT  - Journal of neurointerventional surgery
JID - 101517079
SB  - IM
MH  - *Codes of Ethics
MH  - Conflict of Interest
MH  - Equipment and Supplies/*ethics
MH  - Health Care Sector/*ethics
MH  - Neurosurgery/*ethics
MH  - Physicians/*ethics
MH  - Radiography, Interventional/ethics
MH  - Societies, Medical/*ethics
MH  - United States
EDAT- 2011/10/13 06:00
MHDA- 2012/09/07 06:00
CRDT- 2011/10/13 06:00
PHST- 2011/10/13 06:00 [entrez]
PHST- 2011/10/13 06:00 [pubmed]
PHST- 2012/09/07 06:00 [medline]
AID - jnis.2010.003921 [pii]
AID - 10.1136/jnis.2010.003921 [doi]
PST - ppublish
SO  - J Neurointerv Surg. 2011 Jun;3(2):204-6. doi: 10.1136/jnis.2010.003921. Epub 2010
      Nov 19.


PMID- 21976079
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1949-8357 (Electronic)
IS  - 1949-8357 (Linking)
VI  - 2
IP  - 3
DP  - 2010 Sep
TI  - Potentially discriminatory questions during residency interviews: frequency and
      effects on residents' ranking of programs in the national resident matching
      program.
PG  - 336-40
LID - 10.4300/JGME-D-10-00041.1 [doi]
AB  - BACKGROUND: Medical students rank residency programs as part of the selection
      process in the National Resident Matching Program, also known as the match.
      Applicants to medical residency positions are protected against discriminatory
      employment practices by federal employment laws. OBJECTIVES: To explore students'
      recall of being asked potentially illegal or discriminatory questions during the 
      selection interview, and whether these questions affected students' ranking of
      the programs in the match. METHODS: Fourth-year medical students from a single
      medical school were surveyed after the match. Students were questioned about
      their recall of the frequency of potentially illegal or discriminatory interview 
      questions and their effect on the program's rank. RESULTS: Ninety percent of the 
      63 respondents in the study remember being asked at least one potentially
      discriminatory question. Among these, students were asked about their marital
      status (86%), about children (31%), about plans for pregnancy (10%), where they
      were born (54%) and/or about their national origin (15%), and about religious and
      ethical beliefs (24%). The majority of students did not think the questions
      changed their decision to rank the program, although the questions changed the
      way some students ranked the program, either lowering or raising the rank.
      CONCLUSION: Nearly all students reported that they were asked at least one
      potentially discriminatory question, although these questions for the most part
      do not appear to affect whether they ranked the programs.
FAU - Santen, Sally A
AU  - Santen SA
FAU - Davis, Kevin R
AU  - Davis KR
FAU - Brady, Donald W
AU  - Brady DW
FAU - Hemphill, Robin R
AU  - Hemphill RR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Grad Med Educ
JT  - Journal of graduate medical education
JID - 101521733
PMC - PMC2951770
EDAT- 2011/10/07 06:00
MHDA- 2011/10/07 06:01
CRDT- 2011/10/07 06:00
PHST- 2010/03/06 00:00 [received]
PHST- 2010/04/25 00:00 [revised]
PHST- 2010/06/23 00:00 [accepted]
PHST- 2011/10/07 06:00 [entrez]
PHST- 2011/10/07 06:00 [pubmed]
PHST- 2011/10/07 06:01 [medline]
AID - 10.4300/JGME-D-10-00041.1 [doi]
AID - JGME-D-10-00041 [pii]
PST - ppublish
SO  - J Grad Med Educ. 2010 Sep;2(3):336-40. doi: 10.4300/JGME-D-10-00041.1.


PMID- 21928422
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20131121
IS  - 1097-0347 (Electronic)
IS  - 1043-3074 (Linking)
VI  - 33
IP  - 10
DP  - 2011 Oct
TI  - Retained role of surgery for olfactory neuroblastoma.
PG  - 1486-92
LID - 10.1002/hed.21644 [doi]
AB  - BACKGROUND: Olfactory neuroblastoma is a rare paranasal sinus malignancy. The
      traditional approach was craniofacial resection (CFR) and then postoperative
      radiotherapy until 1998. This review will chart development of a new protocol.
      METHODS: This ethics-approved audit evaluated the number of new patients
      diagnosed with olfactory neuroblastoma, with information relating to patient,
      disease, and treatment factors noted. RESULTS: There were 24 eligible patients,
      16 men, 8 women, 7 Kadish stage B, 17 stage C. The planned treatment was:
      chemotherapy (cisplatin/etoposide) and determine treatment dependent on response 
      in 6 patients, surgery and radiotherapy in 16 patients, and single-modality
      treatment only (surgery, radiotherapy 1) in 2 patients. Surgery to radiotherapy
      occurred in 17 patients. With salvage treatment ultimate local control was 79%.
      CONCLUSIONS: There was a higher local control in those patients who had surgery; 
      abandoning this may carry a higher risk of local failure. The use of response to 
      chemotherapy to determine local treatment remains experimental.
CI  - Copyright (c) 2010 Wiley Periodicals, Inc.
FAU - Smee, Robert I
AU  - Smee RI
AD  - Department of Radiation Oncology, The Prince of Wales Cancer Centre, Randwick,
      New South Wales, Australia. robert.smee@sesiahs.health.nsw.gov.au
FAU - Broadley, Kathryn
AU  - Broadley K
FAU - Williams, Janet R
AU  - Williams JR
FAU - Meagher, Nicola S
AU  - Meagher NS
FAU - Bridger, G Patrick
AU  - Bridger GP
LA  - eng
PT  - Journal Article
DEP - 20101215
PL  - United States
TA  - Head Neck
JT  - Head & neck
JID - 8902541
RN  - 6PLQ3CP4P3 (Etoposide)
RN  - Q20Q21Q62J (Cisplatin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
MH  - Cisplatin/administration & dosage
MH  - Clinical Audit
MH  - Clinical Protocols
MH  - Esthesioneuroblastoma, Olfactory/mortality/pathology/*therapy
MH  - Etoposide/administration & dosage
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nasal Cavity/pathology/*surgery
MH  - Neoadjuvant Therapy
MH  - Neoplasm Recurrence, Local/therapy
MH  - Nose Neoplasms/mortality/pathology/*therapy
MH  - Radiotherapy, Adjuvant
MH  - Radiotherapy, Intensity-Modulated
MH  - Young Adult
EDAT- 2011/09/20 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/09/20 06:00
PHST- 2009/03/24 00:00 [received]
PHST- 2010/08/29 00:00 [revised]
PHST- 2010/09/06 00:00 [accepted]
PHST- 2011/09/20 06:00 [entrez]
PHST- 2011/09/20 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - 10.1002/hed.21644 [doi]
PST - ppublish
SO  - Head Neck. 2011 Oct;33(10):1486-92. doi: 10.1002/hed.21644. Epub 2010 Dec 15.


PMID- 21921564
OWN - NLM
STAT- MEDLINE
DCOM- 20120917
LR  - 20190918
IS  - 1882-0654 (Electronic)
IS  - 0009-918X (Linking)
VI  - 50
IP  - 11
DP  - 2010 Nov
TI  - [Analysis of the shortage of doctors in the university hospital in central Tokyo 
      and a plan for future improvements].
PG  - 1059-62
AB  - The increase in the aging population, the drastic change to a new system for
      postgraduate clinical training, and the lack of medical doctors have all become
      objects of national concern. Medical divide and melt down of the medical system
      brought stress especially to rural areas. Other types of stress are also found in
      urban University hospitals where doctors are forced to accomplish tons of paper
      work, while struggling on research, education, and clinical work. In this
      symposium, I would like to show some background and reasons for the shortage of
      the doctors in Japan. I also present our daily clinical practice and approach for
      new residents. I will also discuss the future improvement of our medical system
      especially in the field of Neurology. We need to show strong leadership and
      appeal to our comrades with medical ethics, one's dignity or self-esteem as a
      doctor.
FAU - Yokoyama, Kazumasa
AU  - Yokoyama K
AD  - Department of Neurology, Juntendo University School of Medicine.
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Rinsho Shinkeigaku
JT  - Rinsho shinkeigaku = Clinical neurology
JID - 0417466
SB  - IM
MH  - Health Plan Implementation/*trends
MH  - *Hospitals, University
MH  - Humans
MH  - *Medically Underserved Area
MH  - *Neurology
MH  - Physicians/*statistics & numerical data
MH  - Tokyo/epidemiology
MH  - Workforce
EDAT- 2011/09/17 06:00
MHDA- 2012/09/18 06:00
CRDT- 2011/09/17 06:00
PHST- 2011/09/17 06:00 [entrez]
PHST- 2011/09/17 06:00 [pubmed]
PHST- 2012/09/18 06:00 [medline]
AID - JST.JSTAGE/clinicalneurol/50.1059 [pii]
AID - 10.5692/clinicalneurol.50.1059 [doi]
PST - ppublish
SO  - Rinsho Shinkeigaku. 2010 Nov;50(11):1059-62. doi: 10.5692/clinicalneurol.50.1059.


PMID- 21921554
OWN - NLM
STAT- MEDLINE
DCOM- 20120917
LR  - 20190918
IS  - 1882-0654 (Electronic)
IS  - 0009-918X (Linking)
VI  - 50
IP  - 11
DP  - 2010 Nov
TI  - [Withdrawal of life-support from ALS patients in so called totally locked in
      state: from the viewpoint of clinical ethics].
PG  - 1029-30
AB  - In Japanese context, there has been a controversy concerning the withdrawal of
      life-support, i.e. respiratory system, from ALS patients when, along of the
      progress of the disease, they have become not able to express themselves at all
      to people around them, i.e. when they are in so called 'totally locked in state
      (TLS)'. Basing himself on the system of clinical ethics he has been developing in
      accord with Japanese culture, the author (1) reconstitutes the logic of
      justifying the withdrawal in dispute, (2) examines objections against officially 
      recognizing such withdrawal, and (3) proposes an appropriate process of decision 
      making which he hopes to be acceptable to both sides in the controversy.
FAU - Shimizu, Tetsuro
AU  - Shimizu T
AD  - Uehiro Endowed Chair for Death and Life Studies, Graduate School of Humanities
      and Sociology, The University of Tokyo.
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Rinsho Shinkeigaku
JT  - Rinsho shinkeigaku = Clinical neurology
JID - 0417466
SB  - IM
MH  - Amyotrophic Lateral Sclerosis/physiopathology/*therapy
MH  - Culture
MH  - Decision Making/ethics
MH  - *Ethics, Clinical
MH  - Humans
MH  - Japan
MH  - Life Support Systems/*ethics
MH  - Ventilators, Mechanical/*ethics
MH  - Withholding Treatment/*ethics
EDAT- 2011/09/17 06:00
MHDA- 2012/09/18 06:00
CRDT- 2011/09/17 06:00
PHST- 2011/09/17 06:00 [entrez]
PHST- 2011/09/17 06:00 [pubmed]
PHST- 2012/09/18 06:00 [medline]
AID - JST.JSTAGE/clinicalneurol/50.1029 [pii]
AID - 10.5692/clinicalneurol.50.1029 [doi]
PST - ppublish
SO  - Rinsho Shinkeigaku. 2010 Nov;50(11):1029-30. doi: 10.5692/clinicalneurol.50.1029.


PMID- 21916095
OWN - NLM
STAT- MEDLINE
DCOM- 20110929
LR  - 20110915
IS  - 0017-7768 (Print)
IS  - 0017-7768 (Linking)
VI  - 149
IP  - 12
DP  - 2010 Dec
TI  - [Complementary and alternative medical information on Israeli medical
      institutions' web sites in 2009: the desirable vs. the available].
PG  - 758-62, 813
AB  - BACKGROUND: Although complementary and alternative medicine [CAM] is a term
      commonly used to denote practices that lie beyond the dominant medical orthodoxy,
      these practices are penetrating Israeli medical institutions. The purpose of the 
      study was to evaluate CAM information on medical institutions' web sites in
      relation to the type of information considered to be significant by integrative
      physicians. The methods employed included evaluating CAM information on the
      websites of: all four health insurance agencies, the eleven largest hospitals in 
      Israel, the Ministry of Health, and the Israeli Medical Association. This data
      was compared to the primary and most meaningful information stressed by
      integrative physicians at their conferences and work-meetings. RESULTS: The
      information on the insurance agencies' web sites is extensive and prominent,
      while on the other sites it is more concise and less prominent. A total of 31
      diverse CAM methods are mentioned on all healthcare websites, while the Ministry 
      of Health site mentions only four of them. Most sites list only advantages or
      drawbacks of these methods. Research findings on efficacy and safety, and
      information on the ethics and legality of CAM practitioners is virtually almost
      non-existent. CONCLUSIONS: While CAM is portrayed on some of the healthcare
      organizations' websites as an attractive commodity, on others it is presented as 
      a separate area to be kept under biomedical scrutiny. One would expect healthcare
      institutions and the Ministry of Health to provide the public with balanced and
      sufficient information to enable patients to make informed choices and facilitate
      better integration of CAM with conventional treatments.
FAU - Keshet, Yael
AU  - Keshet Y
AD  - Western Galilee Academic College, The Max Stern Academic College of Emek Yezreel,
      Israel. Yaelke@yvc.ac.il
LA  - heb
PT  - English Abstract
PT  - Journal Article
PL  - Israel
TA  - Harefuah
JT  - Harefuah
JID - 0034351
SB  - IM
MH  - Complementary Therapies/organization & administration/*statistics & numerical
      data
MH  - Humans
MH  - Integrative Medicine/methods
MH  - Internet/*standards
MH  - Israel
EDAT- 2011/09/16 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/09/16 06:00
PHST- 2011/09/16 06:00 [entrez]
PHST- 2011/09/16 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
PST - ppublish
SO  - Harefuah. 2010 Dec;149(12):758-62, 813.


PMID- 21886373
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 0300-0508 (Print)
IS  - 0300-0508 (Linking)
VI  - 62
IP  - 4
DP  - 2010 Fall
TI  - Ethics of involving children in health-related research: applying a
      decision-making framework to a clinical trial.
PG  - 338-46
LID - 10.3138/physio.62.4.338 [doi]
AB  - PURPOSE: This paper explores ethical issues related to the involvement of
      children in health-related research through the application of a conceptual model
      (the Miller and Kenny framework) to a current clinical trial on casting protocols
      for equinus gait of children with cerebral palsy (CP). SUMMARY OF KEY POINTS: The
      direct involvement of children in health-related research is important for
      maintaining and improving standards of paediatric clinical care. Ethical
      considerations around investigations involving this highly vulnerable population 
      are complex, however, requiring the involvement of many levels of decision
      makers-government, research ethics boards (REBs), health care providers, parents,
      and children. The Miller and Kenny framework is useful in distinguishing these
      levels and heightening awareness of the complexities of the issues around
      engaging children in research. Considerations include the role of
      parents/caregivers in decision making, individual assessment of the child's
      decisional capacities, close attention to the child's context and life
      experience, provision of developmentally appropriate information about the
      research study, and careful assessment of dissent prior to withdrawing the child 
      from the study. RECOMMENDATIONS: Physical therapists involved in paediatric
      clinical practice and/or research must be knowledgeable about ethical principles,
      policies, and REB requirements. The Miller and Kenny framework is a helpful guide
      to clarify decision-making roles around children's participation in research.
FAU - Kelly, Barbara
AU  - Kelly B
AD  - Barbara Kelly, BScPT, MSc (Rehab Research): Physiotherapist, IWK Health Centre,
      Halifax, Nova Scotia; Instructor, School of Physiotherapy, Dalhousie University, 
      Halifax, Nova Scotia.
FAU - Mackay-Lyons, Marilyn J
AU  - Mackay-Lyons MJ
LA  - eng
PT  - Journal Article
DEP - 20101018
PL  - Canada
TA  - Physiother Can
JT  - Physiotherapy Canada. Physiotherapie Canada
JID - 0346574
PMC - PMC2958080
OTO - NOTNLM
OT  - REB requirements
OT  - assent
OT  - children
OT  - dissent
OT  - ethical issues
OT  - research participation
EDAT- 2011/09/03 06:00
MHDA- 2011/09/03 06:01
CRDT- 2011/09/03 06:00
PHST- 2011/09/03 06:00 [entrez]
PHST- 2011/09/03 06:00 [pubmed]
PHST- 2011/09/03 06:01 [medline]
AID - 10.3138/physio.62.4.338 [doi]
AID - physio.62.4.338 [pii]
PST - ppublish
SO  - Physiother Can. 2010 Fall;62(4):338-46. doi: 10.3138/physio.62.4.338. Epub 2010
      Oct 18.


PMID- 21882470
STAT- Publisher
DA  - 20110902
ISBN- 9781439812099
PB  - CRC Press/Taylor & Francis
CTI - Frontiers in Neuroscience
DP  - 2010
TI  - Large Animal Models for Pain Therapeutic Development
BTI - Translational Pain Research: From Mouse to Man
CP  - Chapter 17
AB  - The humane use of preclinical animal models plays a critical role both in
      understanding the basic biology of pain as well as in the development of
      therapeutic treatments to alleviate pain. Clinically relevant pain is the result 
      of complex processes involving peripheral transduction and transmission as well
      as central modulation and processing that leads to the final conscious sensation 
      of pain. Much has been learned about the mechanisms underlying the transduction
      and transmission of the pain signal within the nervous system through the use of 
      cellular, biochemical, and molecular techniques (Millan 1999; Scholz and Woolf
      2007; Zeilhofer 2005). However, understanding the actual experience of pain will 
      always require an intact organism that can integrate the full range of external
      stimuli and internal cognitive and emotional states that drive and modulate pain.
      Rodent models of pain have historically played a dominant role in the study of
      pain mechanisms (Negus et al. 2006; Walker et al. 1999). There are many good
      reasons for this, including the practicalities of low cost, simplified ethical
      concerns, and the scientific value of having a large database of prior research
      to provide context for new findings. A large historical database is particularly 
      important in the field of drug discovery and development since the sensitivity
      and predictive validity of animal models can only be established through
      extensive testing in many contexts. For these reasons, the rat and mouse models
      will continue to be the workhorses driving basic research as well as drug
      discovery. Unfortunately, there are many ways that the biology of rodents may
      fail to accurately predict the biology and pharmacology of clinical pain
      conditions in humans (Blackburn -Munro 2004; Le Bars et al. 2001). Given the high
      cost of developing new therapeutics (Adams and Brantner 2006), there is a growing
      need to validate biological and pharmacological findings in non-rodent species
      that, while perhaps less tractable than rodents, address known or ill-defined
      differences between mice and men. It is hoped that through the humane study and
      evaluation of pain states in higher order preclinical species, we can better
      predict whether biological mechanisms and specific compounds have relevance for
      clinical pain. Ultimately, well-validated pain models in non-rodent species could
      enhance the speed, reduce the costs, and increase the probability of the
      successful development of new analgesic therapeutics offering enhanced efficacy
      and reduced adverse effects. This chapter will review the gaps in current pain
      research using rodent models that may potentially be addressed using preclinical 
      animal models of pain in higher species. Additionally, we will review the pain
      models and assessments that have been developed to date in "higher" and larger
      species and highlight areas where there is a need for the development of new
      models and methods of pain assessment.
CI  - Copyright (c) 2010 by Taylor and Francis Group, LLC.
FED - Kruger, Lawrence
ED  - Kruger L
FED - Light, Alan R.
ED  - Light AR
FAU - Henze, Darrell A.
AU  - Henze DA
FAU - Urban, Mark O.
AU  - Urban MO
LA  - eng
PT  - Review
PT  - Book Chapter
PL  - Boca Raton (FL)
EDAT- 2011/09/02 06:00
MHDA- 2011/09/02 06:00
CDAT- 2011/09/02 06:00
AID - NBK57273 [bookaccession]


PMID- 21877423
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20170214
IS  - 0957-154X (Print)
IS  - 0957-154X (Linking)
VI  - 21
IP  - 84 Pt 4
DP  - 2010 Dec
TI  - Malaria fever therapy for general paralysis of the insane in Denmark.
PG  - 471-86
AB  - This article explores the history of general paralysis and malaria fever therapy 
      in Denmark. I argue that the small size of the country gave Danish psychiatrists 
      excellent opportunities for performing statistical studies of general paralysis
      in the 19th century. In the early 1920s malaria fever therapy was introduced in
      Danish mental hospitals and raised hopes of a cure for paralytics. Malaria fever 
      therapy became popular among Danish psychiatrists, but the new therapy also
      raised ethical questions and led to the first regulations concerning informed
      consent in the history of Danish psychiatry.
FAU - Kragh, Jesper Vaczy
AU  - Kragh JV
AD  - Institute of Public Health, University of Copenhagen, Fredericiagade 18, DK- 130 
      I Copenhagen K, Denmark. jkvy@sund.ku.dk
LA  - eng
PT  - Biography
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Hist Psychiatry
JT  - History of psychiatry
JID - 9013819
MH  - Denmark
MH  - History, 19th Century
MH  - History, 20th Century
MH  - Hospitals, Psychiatric/*history
MH  - Humans
MH  - Hyperthermia, Induced/*history
MH  - Malaria/*history
MH  - Neurosyphilis/*history
MH  - Psychiatry/*history
PS  - Wagner-Jauregg J
FPS - Wagner-Jauregg, Julius
EDAT- 2011/09/01 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/09/01 06:00
PHST- 2011/09/01 06:00 [entrez]
PHST- 2011/09/01 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 10.1177/0957154X09338085 [doi]
PST - ppublish
SO  - Hist Psychiatry. 2010 Dec;21(84 Pt 4):471-86. doi: 10.1177/0957154X09338085.


PMID- 21834198
STAT- Publisher
DA  - 20110812
ISBN- 9781854334787
PB  - British Psychological Society
CTI - National Institute for Health and Clinical Excellence: Guidance
DP  - 2010
BTI - Antisocial Personality Disorder: Treatment, Management and Prevention
AB  - The guideline on Antisocial Personality Disorder, commissioned by NICE and
      developed by the National Collaborating Centre for Mental Health, sets out clear,
      evidence- and consensus-based recommendations for staff working in health and
      social care and the criminal justice system on how to treat, manage and prevent
      antisocial personality disorder. The NICE guideline takes the first comprehensive
      view of antisocial personality disorder and is an invaluable resource to enable
      professionals to improve the outcomes for people with the disorder, who often
      have significant impairments. Being able to prevent and properly manage
      antisocial personality disorder will also have considerable social implications. 
      This publication brings together all of the evidence that led to the
      recommendations in the NICE guideline, and draws on a wide literature, including 
      evidence for the management of offending behaviour. It includes a review of
      interventions in children and young people with conduct disorder, which may
      prevent the development of antisocial personality disorder; risk assessment and
      management; organisation and experience of care; and a range of interventions for
      adults with antisocial personality disorder, including psychological
      interventions, treatment for comorbid disorders, therapeutic communities and
      pharmacological interventions. The book also contains a useful overview of
      antisocial personality disorder, including ethical considerations.
CI  - Copyright (c) 2010, The British Psychological Society & The Royal College of
      Psychiatrists.
CN  - National Collaborating Centre for Mental Health (UK)
LA  - eng
PT  - Review
PT  - Book
PL  - Leicester (UK)
EDAT- 2011/08/12 06:00
MHDA- 2011/08/12 06:00
CDAT- 2011/08/12 06:00
AID - NBK55345 [bookaccession]


PMID- 21814629
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 2229-5488 (Electronic)
IS  - 2229-3485 (Linking)
VI  - 1
IP  - 3
DP  - 2010 Jul
TI  - Patient protection in clinical trials in India: some concerns.
PG  - 101-3
AB  - Clinical trial participants should not be influenced by undue inducement.
      Clinical trial investigators should be guided by ethical principles, and patient 
      protection should be a top priority. This does not seem to be the case in India.
FAU - Srinivasan, Sandhya
AU  - Srinivasan S
AD  - Executive Editor, Indian Journal of Medical Ethics.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Perspect Clin Res
JT  - Perspectives in clinical research
JID - 101551517
PMC - PMC3146073
OTO - NOTNLM
OT  - Consent
OT  - Ethics
OT  - Patient Protection
OT  - Patient Recruitment
EDAT- 2011/08/05 06:00
MHDA- 2011/08/05 06:01
CRDT- 2011/08/05 06:00
PHST- 2011/08/05 06:00 [entrez]
PHST- 2011/08/05 06:00 [pubmed]
PHST- 2011/08/05 06:01 [medline]
PST - ppublish
SO  - Perspect Clin Res. 2010 Jul;1(3):101-3.


PMID- 21814627
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 2229-5488 (Electronic)
IS  - 2229-3485 (Linking)
VI  - 1
IP  - 3
DP  - 2010 Jul
TI  - Survey on perceptions of Indian investigators on research ethics.
PG  - 94-7
AB  - INTRODUCTION: The last decade has witnessed globalization of drug development
      with early phase studies being increasingly placed in the developing world.
      Whether research related ethical principles around informed consent, adverse
      event (AE) reporting, post trial drug commitments and others are being observed, 
      merits evaluation METHODS: A specially designed survey questionnaire was served
      to 29 investigators in India, having prior experience of participating in drug
      development studies with pharmaceutical companies. The survey included questions 
      on investigator profile, study design, informed consent process, safety
      reporting, patient and physician compensation, post trial drug commitments among 
      others RESULTS: Most respondents had nearly two decades of clinical experience.
      Majority believed that the research they conducted was relevant to the needs of
      society, but wanted common research goals established between the sponsors and
      the community. All investigators cited their expertise, reliability, patient
      pool, and low costs as the principal reasons for greater placement of studies.
      However, very few investigators felt that all their patients in studies were
      "truly autonomous". Most investigators indicated confidence in the adverse event 
      reporting ability and expressed satisfaction with their Ethics Committees. A
      third of investigators accepted some form of conflict of interest between their
      role as a physician and researcher. Opinion was divided regarding satisfaction
      with the post trial drug commitments of the sponsor companies CONCLUSION: The
      survey revealed a good understanding of the ethical issues around conduct of
      clinical research in a developing country. The sooner ethical institutions and
      practices are fortified, the better it is for communities, patients,
      investigators and pharmaceutical sponsors.
FAU - Bindra, Sutinder
AU  - Bindra S
AD  - Head Medical and Clinical Affairs Asia Region.
FAU - Kochhar, Puja
AU  - Kochhar P
LA  - eng
PT  - Journal Article
PL  - India
TA  - Perspect Clin Res
JT  - Perspectives in clinical research
JID - 101551517
PMC - PMC3146079
OTO - NOTNLM
OT  - Clinical Research
OT  - India
OT  - Research Ethics
EDAT- 2011/08/05 06:00
MHDA- 2011/08/05 06:01
CRDT- 2011/08/05 06:00
PHST- 2011/08/05 06:00 [entrez]
PHST- 2011/08/05 06:00 [pubmed]
PHST- 2011/08/05 06:01 [medline]
PST - ppublish
SO  - Perspect Clin Res. 2010 Jul;1(3):94-7.


PMID- 21812199
OWN - NLM
STAT- MEDLINE
DCOM- 20111206
LR  - 20211020
IS  - 1118-4841 (Print)
IS  - 1118-4841 (Linking)
VI  - 14
IP  - 4 Spec no.
DP  - 2010 Dec
TI  - Assessing the importance of gender roles in couples' home-based sexual health
      services in Malawi.
PG  - 61-71
AB  - To more effectively address individuals' and couples' sexual and reproductive
      health needs, innovative service delivery strategies are being explored. These
      strategies are logistically and ethically complicated, considering prevailing
      gender inequalities in many contexts. We conducted an exploratory study to assess
      the acceptability of couples' home-based sexual health services in Malawi. We
      collected qualitative data from six focus group discussions and 10 husband-wife
      indepth interviews to gain a more thorough understanding of how gender norms
      influence acceptability of couples' sexual health services. Findings reveal that 
      women are expected to defer to their husbands and may avoid conflict through
      covert contraceptive use and non-disclosure of HIV status. Many men felt that
      accessing sexual health services is stigmatizing, causing some to avoid services 
      or to rely on informal information sources. Gender norms and attitudes toward
      existing services differentially impact men and women in this setting,
      influencing the perceived benefits of couples' sexual health services.
FAU - Gipson, Jessica D
AU  - Gipson JD
AD  - Department of Community Health Sciences, University of California, Los Angeles
      School of Public Health, 650 Charles E. Young Drive South, CHS 46-071B, Los
      Angeles, CA 90095-1772, USA. jgipson@ucla.edu
FAU - Muntifering, Carie J
AU  - Muntifering CJ
FAU - Chauwa, Felluna K
AU  - Chauwa FK
FAU - Taulo, Frank
AU  - Taulo F
FAU - Tsui, Amy O
AU  - Tsui AO
FAU - Hindin, Michelle J
AU  - Hindin MJ
LA  - eng
GR  - R24 HD041022/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Nigeria
TA  - Afr J Reprod Health
JT  - African journal of reproductive health
JID - 9712263
SB  - IM
MH  - Adult
MH  - *Family Planning Services
MH  - Female
MH  - Focus Groups
MH  - *Health Knowledge, Attitudes, Practice
MH  - Health Services Needs and Demand
MH  - *Home Care Services
MH  - Humans
MH  - Interviews as Topic
MH  - Malawi
MH  - Male
MH  - Sex Factors
MH  - *Sexual Partners
PMC - PMC4424046
MID - NIHMS680878
EDAT- 2011/08/05 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/08/05 06:00
PHST- 2011/08/05 06:00 [entrez]
PHST- 2011/08/05 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PST - ppublish
SO  - Afr J Reprod Health. 2010 Dec;14(4 Spec no.):61-71.


PMID- 21808710
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 2035-8164 (Electronic)
IS  - 2035-8164 (Linking)
VI  - 2
IP  - 2
DP  - 2010 Sep 23
TI  - Cell therapy in bone healing disorders.
PG  - e20
LID - 10.4081/or.2010.e20 [doi]
AB  - In addition to osteosynthetic stabilizing techniques and autologous bone
      transplantations, so-called orthobiologics play an increasing role in the
      treatment of bone healing disorders. Besides the use of various growth factors,
      more and more new data suggest that cell-based therapies promote local bone
      regeneration. For ethical and biological reasons, clinical application of
      progenitor cells on the musculoskeletal system is limited to autologous,
      postpartum stem cells. Intraoperative one-step treatment with autologous
      progenitor cells, in particular, delivered promising results in preliminary
      clinical studies. This article provides an overview of the rationale for, and
      characteristics of the clinical application of cell-based therapy to treat
      osseous defects based on a review of existing literature and our own experience
      with more than 100 patients. Most clinical trials report successful bone
      regeneration after the application of mixed cell populations from bone marrow.
      The autologous application of human bone marrow cells which are not expanded ex
      vivo has medico-legal advantages. However, there is a lack of prospective
      randomized studies including controls for cell therapy for bone defects.
      Autologous bone marrow cell therapy seems to be a promising treatment option
      which may reduce the amount of bone grafting in future.
FAU - Jager, Marcus
AU  - Jager M
AD  - Dept. of Orthopaedics, University Hospital Dusseldorf, Heinrich-Heine-University 
      Dusseldorf, Moorenstr Dusseldorf, Germany;
FAU - Hernigou, Philippe
AU  - Hernigou P
FAU - Zilkens, Christoph
AU  - Zilkens C
FAU - Herten, Monika
AU  - Herten M
FAU - Li, Xinning
AU  - Li X
FAU - Fischer, Johannes
AU  - Fischer J
FAU - Krauspe, Rudiger
AU  - Krauspe R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Orthop Rev (Pavia)
JT  - Orthopedic reviews
JID - 101524779
PMC - PMC3143975
OTO - NOTNLM
OT  - bone defect
OT  - cell therapy
OT  - osteoblast.
OT  - stem cell
EDAT- 2011/08/03 06:00
MHDA- 2011/08/03 06:01
CRDT- 2011/08/03 06:00
PHST- 2010/08/03 00:00 [received]
PHST- 2010/08/19 00:00 [accepted]
PHST- 2011/08/03 06:00 [entrez]
PHST- 2011/08/03 06:00 [pubmed]
PHST- 2011/08/03 06:01 [medline]
AID - 10.4081/or.2010.e20 [doi]
AID - or.2010.e20 [pii]
PST - ppublish
SO  - Orthop Rev (Pavia). 2010 Sep 23;2(2):e20. doi: 10.4081/or.2010.e20.


PMID- 21772798
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1532-0065 (Electronic)
IS  - 1531-5010 (Linking)
VI  - 20
IP  - 6
DP  - 2010 Nov
TI  - Distal superficial temporal artery to proximal posterior cerebral artery bypass
      by posterior oblique transzygomatic subtemporal approach.
PG  - 415-20
LID - 10.1055/s-0030-1254405 [doi]
AB  - This article investigates the possibility for the distal superficial temporal
      artery (STA) to proximal posterior cerebral artery (PCA) direct bypass by
      subtemporal oblique posterior transzygomatic approach. Five adult cadaveric
      specimens were dissected. Cadeveric dissection protocol was approved by the
      Research Ethics Committee. A preauricular vertical skin incision was made, the
      trunk of STA was identified, and bifurcation, frontal, and parietal branches of
      the STA were followed distally. Posterior zygomatic arch osteotomy and
      microcraniotomy were then performed, and the dura was opened. The temporal lobe
      was retracted, interpeduncular and ambient cisterns were opened, and the P2
      segment of the PCA was exposed. Parietal branch of STA and P2 segment of the PCA 
      was anastomosed. The average length of the transected STA from the bifurcation
      and the zygomatic arch were 47.3 +/- 2.1 mm and 71.4 +/- 2.3 mm, respectively.
      The mean calibers of the parietal and frontal branch of the STA at this distance 
      were 1.6 +/- 0.1 and 1.4 +/- 0.2, respectively. The mean diameter of the P2 was
      2.1 +/- 0.2 mm. Because of the calibers of the parietal branch of the STA and
      proximal PCA are over 1.5 mm and 2.0 mm, respectively, this direct end-to-side
      bypass technique may be a reasonable alternative in suitable cases.
FAU - Ulku, Cagatay Han
AU  - Ulku CH
FAU - Ustun, Mehmet Erkan
AU  - Ustun ME
FAU - Buyukmumcu, Mustafa
AU  - Buyukmumcu M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Skull Base
JT  - Skull base : official journal of North American Skull Base Society ... [et al.]
JID - 101090660
PMC - PMC3134812
OTO - NOTNLM
OT  - Bypass
OT  - posterior cerebral artery
OT  - revascularization
OT  - superficial temporal artery
EDAT- 2011/07/21 06:00
MHDA- 2011/07/21 06:01
CRDT- 2011/07/21 06:00
PHST- 2011/07/21 06:00 [entrez]
PHST- 2011/07/21 06:00 [pubmed]
PHST- 2011/07/21 06:01 [medline]
AID - 10.1055/s-0030-1254405 [doi]
PST - ppublish
SO  - Skull Base. 2010 Nov;20(6):415-20. doi: 10.1055/s-0030-1254405.


PMID- 21766729
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20191112
IS  - 1145-0762 (Print)
IS  - 1145-0762 (Linking)
VI  - 21
IP  - 4
DP  - 2010 Dec
TI  - Is there a death with dignity in today's medicine?
PG  - 149-56, 167
AB  - This paper deliberates on one of the all-time issues in philosophy, theology,
      (bio)ethics and medicine, that is, the issue of death and dying, placing it in a 
      contemporary context. Namely, contemporary medicine with its expanding knowledge 
      in the field of biomedical science and technology, requires a new approach in
      determination of its goals. Nowadays, more than ever, these goals need a revision
      from an interdisciplinary point of view. Exactly in the context of those goals,
      the issue of death and dying should be approached, taking into account four
      entities known in clinical bioethics, i.e. the bioethical classification of death
      and dying: euthanasia, mysthanasia, dysthanasia and orthothanasia.
FAU - Sorta-Bilajac, Iva
AU  - Sorta-Bilajac I
AD  - Department of Medical Humanities and Social Sciences, University of Rijeka School
      of Medicine, Rijeka, Croatia.
FAU - Segota, Ivan
AU  - Segota I
LA  - eng
PT  - Journal Article
PL  - France
TA  - J Int Bioethique
JT  - Journal international de bioethique = International journal of bioethics
JID - 9015754
SB  - IM
MH  - *Attitude to Death
MH  - *Bioethical Issues
MH  - Humans
MH  - *Personhood
MH  - Quality of Life
EDAT- 2011/07/20 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/07/20 06:00
PHST- 2011/07/20 06:00 [entrez]
PHST- 2011/07/20 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 10.3917/jib.214.0149 [doi]
PST - ppublish
SO  - J Int Bioethique. 2010 Dec;21(4):149-56, 167. doi: 10.3917/jib.214.0149.


PMID- 21766727
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110927
LR  - 20191112
IS  - 1145-0762 (Print)
IS  - 1145-0762 (Linking)
VI  - 21
IP  - 4
DP  - 2010 Dec
TI  - Reflections on the function of dignity in the context of caring for old people.
PG  - 123-34, 165
AB  - This paper accepts the proposition that old people want to be treated with
      dignity and that statements about dignity point to ethical duties that, if not
      independent of rights, at least enhance rights in ethically important ways. In
      contexts of policy and law, dignity can certainly have a substantive as well as
      rhetorical function. However, the paper questions whether the concept of dignity 
      can provide practical guidance for choosing among alternative approaches to the
      care of old people. The paper explores the paradoxical relationship between the
      apparent lack of specific content in many conceptions of dignity and the broad
      utility that dignity appears to have as a concept expressive of shared social
      understandings about the status of old people.
FAU - Agich, George J
AU  - Agich GJ
AD  - Social Philosophy and Policy Center, Bowling Green State University, Shatzel
      Hall, Bowling Green, OH 43403, USA. agichg@bgsu.edu
LA  - eng
PT  - Journal Article
PL  - France
TA  - J Int Bioethique
JT  - Journal international de bioethique = International journal of bioethics
JID - 9015754
RPF - J Med Philos. 2007 Sep-Oct;32(5):483-94. PMID: 17924273
EDAT- 2011/07/20 06:00
MHDA- 2011/07/20 06:01
CRDT- 2011/07/20 06:00
PHST- 2011/07/20 06:00 [entrez]
PHST- 2011/07/20 06:00 [pubmed]
PHST- 2011/07/20 06:01 [medline]
AID - 10.3917/jib.214.0123 [doi]
PST - ppublish
SO  - J Int Bioethique. 2010 Dec;21(4):123-34, 165. doi: 10.3917/jib.214.0123.


PMID- 21766726
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20191112
IS  - 1145-0762 (Print)
IS  - 1145-0762 (Linking)
VI  - 21
IP  - 4
DP  - 2010 Dec
TI  - Dignity and informed consent in the treatment of mature minors.
PG  - 103-22, 164-5
AB  - In today's world, as evinced in various human rights provisions, emphasis is
      placed on the assertion and protection of the entrenched rights of every human
      and particularly the dignity of humans and respect of human autonomy.
      Medical/health workers are concerned about protecting every patient's right to
      the dignity of his or her person. This led to the formulation of the concept of
      self determination and informed consent in medical diagnosis and treatments.
      However, serious concern is placed on these principles especially as it affects
      mature minors, a group of individuals who by conduct demand a level of respect
      but may at the same time be viewed as not capable of making the "best" informed
      decisions, especially about health. The following issues may arise as a result of
      the aforementioned concerns: --are mature young ones entitled to right of self
      determination and informed consent despite the alleged fear that they may lack
      capacity to make informed decisions? --if no, who should decide on their
      behalf--their parents, their medical/health provider or the society/government
      (especially since the 3 (three) interested groups may have different and
      conflicting stands on what is best for the child); --if the answer to the initial
      question is yes, to what extent should mature minors be informed of their medical
      choices and be allowed to exercise their right of self determination? --should
      they be guided? --and who should so guide them? In resolving the above issue, due
      consideration has been given not only to legal and bio-ethical provisions of some
      countries but also to international conventions which several countries are party
      to. Thereafter, it became clear that most authorities are of the view that mature
      minors should be fully informed and be allowed to have a say in health decisions,
      coaching them with few exceptions. Ultimately, because of the importance of
      respect for human dignity, autonomy and self determination along with medical
      disclosure in today's world, it will be recommended that laws in a number of
      jurisdictions need to be reviewed to reflect the current international trend and 
      amended or replaced as the need might be.
FAU - Bello, Bidemi Ademola
AU  - Bello BA
AD  - S. B. Joseph & Co., 140, Borno Way, Ebute Metta, Lagos, Nigeria.
      bidemola@yahoo.com
LA  - eng
PT  - Journal Article
PL  - France
TA  - J Int Bioethique
JT  - Journal international de bioethique = International journal of bioethics
JID - 9015754
SB  - IM
MH  - Adolescent
MH  - Humans
MH  - Informed Consent/*legislation & jurisprudence
MH  - Minors/*legislation & jurisprudence
MH  - Personal Autonomy
MH  - *Personhood
MH  - Treatment Refusal/legislation & jurisprudence
EDAT- 2011/07/20 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/07/20 06:00
PHST- 2011/07/20 06:00 [entrez]
PHST- 2011/07/20 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 10.3917/jib.214.0103 [doi]
PST - ppublish
SO  - J Int Bioethique. 2010 Dec;21(4):103-22, 164-5. doi: 10.3917/jib.214.0103.


PMID- 21766725
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20191112
IS  - 1145-0762 (Print)
IS  - 1145-0762 (Linking)
VI  - 21
IP  - 4
DP  - 2010 Dec
TI  - [Respect of patient's dignity in the hospital].
PG  - 93-101, 162-3
AB  - Every code of ethics of health professionals in France considers the respect of
      dignity as a fundamental duty. The French 2002 Law on patient rights says that
      the person has the right to respect of dignity and of private life. After a
      presentation of the articles of ethics codes regarding dignity, this paper
      presents recommendations to deliver medical care in situations where dignity
      might be endangered such as for patients hospitalized in psychiatric services
      without consent, or for medical examination of prisoners or medical care to
      vulnerable patients unable to express their will, especially in palliative care
      or at the end of life. Respect of dignity after death is illustrated by the
      reflection conducted by the Espace Ethique de l'AP-HP (Paris area hospitals) and 
      in the Chart of the mortuary yard. A survey of the patients' letters of complaint
      received by the emergency service of the Toulouse University Hospital showed
      that, in five years, there were 188 letters and 18 pointed out infringements to
      the dignity of the person. The health professional team is now aware of this
      obligation, and in the accreditation of the hospitals, the respect of dignity is 
      one of the indicators of the quality of medical care.
FAU - Duguet, A-M
AU  - Duguet AM
AD  - Faculte de medecine Toulouse, INSERM, UMRS 1027, Toulouse.
      aduguet@club-internet.fr
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Le respect de la dignite a l'hopital.
PL  - France
TA  - J Int Bioethique
JT  - Journal international de bioethique = International journal of bioethics
JID - 9015754
SB  - IM
MH  - Humans
MH  - Informed Consent
MH  - *Inpatients
MH  - Patient Rights/*legislation & jurisprudence
MH  - Personal Autonomy
MH  - *Personhood
MH  - Quality Assurance, Health Care
EDAT- 2011/07/20 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/07/20 06:00
PHST- 2011/07/20 06:00 [entrez]
PHST- 2011/07/20 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 10.3917/jib.214.0093 [doi]
PST - ppublish
SO  - J Int Bioethique. 2010 Dec;21(4):93-101, 162-3. doi: 10.3917/jib.214.0093.


PMID- 21766718
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20110719
IS  - 1145-0762 (Print)
IS  - 1145-0762 (Linking)
VI  - 21
IP  - 4
DP  - 2010 Dec
TI  - Precautionary principle, ethical recklessness and international governance.
PG  - 11-8
FAU - Martin, Jean
AU  - Martin J
AD  - UNESCO, International Bioethics Committee, La Ruelle, Switzerland.
      jean.martin@urbanet.ch
LA  - eng
LA  - fre
PT  - Journal Article
PL  - France
TA  - J Int Bioethique
JT  - Journal international de bioethique = International journal of bioethics
JID - 9015754
SB  - IM
MH  - Cloning, Organism/*ethics/legislation & jurisprudence
MH  - Humans
MH  - Policy Making
MH  - Risk
EDAT- 2011/07/20 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/07/20 06:00
PHST- 2011/07/20 06:00 [entrez]
PHST- 2011/07/20 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
PST - ppublish
SO  - J Int Bioethique. 2010 Dec;21(4):11-8.


PMID- 21761091
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20191112
IS  - 0383-6320 (Print)
IS  - 0383-6320 (Linking)
VI  - 35
IP  - 2
DP  - 2010 Autumn
TI  - [Psychiatric medication as restraint: between autonomy and protection, is there
      place for a legal framework?].
PG  - 163-84
AB  - The use of chemical restraint has been regulated for the past ten years in
      Quebec. However, clinical, ethical and legal issues, sometimes contradictory,
      have not really been considered during the legislative process leading to
      consolidation in its current form. The author supports that, because of the
      absence of consent and the effects of medication, a specific legal framework to
      the use of medication is necessary in a context of unplanned intervention to
      protect both patients and medical staff. This framework would prescribe good
      practice, take into account the non-medical aspects of consent to care and
      formalize the practice as an exception to the rule. In addition, the symbolism of
      law, through which social solidarity can be expressed, must not be
      underestimated.
FAU - Bernheim, Emmanuelle
AU  - Bernheim E
AD  - Professeure au departement des sciences juridiques de l'Universite du Quebec a
      Montreal; Doctorante au Centre de recherche en droit public de l'Universite de
      Montreal.
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - La medication psychiatrique comme contention : entre autonomie et protection,
      quelle place pour un cadre juridique ?
PL  - Canada
TA  - Sante Ment Que
JT  - Sante mentale au Quebec
JID - 9424773
RN  - 0 (Antipsychotic Agents)
SB  - IM
MH  - Antipsychotic Agents/*therapeutic use
MH  - Ethics, Medical
MH  - Human Rights/legislation & jurisprudence
MH  - Humans
MH  - *Personal Autonomy
MH  - Psychomotor Agitation/*drug therapy
EDAT- 2011/07/16 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/07/16 06:00
PHST- 2011/07/16 06:00 [entrez]
PHST- 2011/07/16 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 1000558ar [pii]
AID - 10.7202/1000558ar [doi]
PST - ppublish
SO  - Sante Ment Que. 2010 Autumn;35(2):163-84. doi: 10.7202/1000558ar.


PMID- 21761085
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20191112
IS  - 0383-6320 (Print)
IS  - 0383-6320 (Linking)
VI  - 35
IP  - 2
DP  - 2010 Autumn
TI  - [Preliminary questions to a reflection on clinical impasses].
PG  - 31-46
AB  - The definition of 'clinical impasse' depends not only on the clinician who-as the
      proposed argument suggests-would be faced to his powerlessness in specific
      situations, but this definition is tributary to the clinical and theoretical
      field inscribed within this clinician's practice. Thus, for example, the practice
      of psychotherapy and the practice of psychoanalysis implies very different if not
      opposed positions of the clinician, bringing on the patient's side, very specific
      difficulties and impasses. In the field of psychoanalysis conceived essentially
      as a practice of the ethical, one cannot address this notion of 'clinical
      impasse' without first questioning the position of the analyst, not as much in
      his rapport with theory and technique used but mainly by questioning the point
      and the locus within himself from which he directs the treatment. Likewise, for
      the analysed, can what entails impasse in the treatment be indissociable to the
      ethical position of the subject?
FAU - Cantin, Lucie
AU  - Cantin L
AD  - GIFRIC (Groupe Interdisciplinaire Freudien de Recherche pour l'Intervention
      Clinique).
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Questions prealables a une reflexion sur les impasses cliniques.
PL  - Canada
TA  - Sante Ment Que
JT  - Sante mentale au Quebec
JID - 9424773
SB  - IM
MH  - Humans
MH  - *Psychoanalytic Theory
MH  - *Psychoanalytic Therapy/ethics
EDAT- 2011/07/16 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/07/16 06:00
PHST- 2011/07/16 06:00 [entrez]
PHST- 2011/07/16 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 1000552ar [pii]
AID - 10.7202/1000552ar [doi]
PST - ppublish
SO  - Sante Ment Que. 2010 Autumn;35(2):31-46. doi: 10.7202/1000552ar.


PMID- 21735997
OWN - NLM
STAT- MEDLINE
DCOM- 20110719
LR  - 20110707
IS  - 0309-3913 (Print)
IS  - 0309-3913 (Linking)
VI  - 39
IP  - 4
DP  - 2010 Dec
TI  - Position paper for health authorities: archived clinical pathology data-treasure 
      to revalue and appropriate.
PG  - 311-5
AB  - Archived clinical pathology data (ACPD) is recognized as useful for research.
      Given our privileged de-identified ACPD from South West Pathology Service (SWPS),
      attempt is made to estimate what it would cost any researcher without such
      privilege to generate the same data. The Ethics Committee of the Area Health
      Service approved a request for Dr. Uba Nwose to use de-identified ACPD acquired
      by the SWPS for clinical laboratory-based translational biomedical science
      research. 10-years (1999-2008) have been pooled to constitute the database. Data 
      include blood sugar, cholesterol, D-dime, ESR, glucose tolerance, haematocrit,
      HbA 1 c, homocysteine, serum creatinine, total protein and vitamins [C & E]
      amongst others. For this report, the bulk-billed-cost of tests were estimated
      based on number and unit price of each test performed. AU$ 17,507,136.85 is the
      cost paid by Medicare in the period. This amount is a conservative estimate that 
      could be spent to generate such 10-years data in the absence of ACPD. The
      health/pathology service has not given any financial research grant. However, the
      support-in-kind is worth more than celebrated competitive research grants. It
      calls for revaluatrion by academic, research and scientific institutions the use 
      ofACPD. For the countries where such provision is non-existent, this report
      provides a 'Position Paper' to present to the directorates or institutes of
      health authorities to appropriate the value of ACPD and approve of their use as a
      research treasure and resource management tool.
FAU - Nwose, E U
AU  - Nwose EU
AD  - Western Pathology Cluster--NSW Health, South West Pathology Service, 590 Smollett
      Albury, NSW 2640, Australia. ezekiel.nwose@gsahs.health.nsw.gdv.au
FAU - Richards, R S
AU  - Richards RS
FAU - Butkowski, E
AU  - Butkowski E
FAU - Cann, Nathan
AU  - Cann N
LA  - eng
PT  - Journal Article
PL  - Nigeria
TA  - Afr J Med Med Sci
JT  - African journal of medicine and medical sciences
JID - 7801013
SB  - IM
MH  - Australia
MH  - Biomedical Research/*economics
MH  - Cost-Benefit Analysis
MH  - Health Services Research/*economics
MH  - Humans
MH  - Pathology, Clinical/economics/*statistics & numerical data
MH  - *Registries
MH  - Research Design
EDAT- 2011/07/09 06:00
MHDA- 2011/07/20 06:00
CRDT- 2011/07/09 06:00
PHST- 2011/07/09 06:00 [entrez]
PHST- 2011/07/09 06:00 [pubmed]
PHST- 2011/07/20 06:00 [medline]
PST - ppublish
SO  - Afr J Med Med Sci. 2010 Dec;39(4):311-5.


PMID- 21716861
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 0975-1564 (Electronic)
IS  - 0253-7176 (Linking)
VI  - 32
IP  - 2
DP  - 2010 Jul
TI  - Ethics for medical educators: an overview and fallacies.
PG  - 83-6
LID - 10.4103/0253-7176.78502 [doi]
AB  - Ethics is the rule of right conduct or practice in a profession. The basic
      principles of ethics are beneficence, justice and autonomy or individual freedom.
      There is very minor demarcation between ethics and the law. The ethics is
      promulgated by the professional bodies. All are expected to guide the medical
      professional in their practice. Medical educators have dual ethical obligations: 
      firstly, to the society at large which expects us to produce competent health
      professionals, and secondly, to the students under our care. The students observe
      and copy what their teacher does and his/her role modelling can be a gateway to a
      student's character building. Due to rapid increase in the number of medical
      colleges, privatization, and capitalism, ethical issue has become much more
      relevant and needs to discuss in detail. The present paper discusses the ethics
      for medical educators in detail with, basic principles, common breaches of ethics
      and fallacies due to wrong application of ethical principles, and the approach to
      ethics and methods by which we can prevent and avoid breach of ethics.
FAU - Singh, Arjun
AU  - Singh A
AD  - Department of Pathology, Sri Venkateshwara Medical College Hospital and Research 
      Centre, Pondicherry, India.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Indian J Psychol Med
JT  - Indian journal of psychological medicine
JID - 7910727
PMC - PMC3122542
OTO - NOTNLM
OT  - Ethics for educator
OT  - ethics
OT  - medical education
EDAT- 2011/07/01 06:00
MHDA- 2011/07/01 06:01
CRDT- 2011/07/01 06:00
PHST- 2011/07/01 06:00 [entrez]
PHST- 2011/07/01 06:00 [pubmed]
PHST- 2011/07/01 06:01 [medline]
AID - 10.4103/0253-7176.78502 [doi]
AID - IJPsyM-32-83 [pii]
PST - ppublish
SO  - Indian J Psychol Med. 2010 Jul;32(2):83-6. doi: 10.4103/0253-7176.78502.


PMID- 21713353
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20151119
IS  - 2590-7379 (Electronic)
IS  - 0120-4157 (Linking)
VI  - 30
IP  - 4
DP  - 2010 Oct-Dec
TI  - [Quality of life related to the health of the people affected by burns after the 
      healing].
PG  - 492-500
LID - S0120-41572010000400006 [pii]
AB  - INTRODUCTION: Burn injuries affect the quality of life of the injured as a
      consequence of deformities and loss of bodily function. Objective. Changes in the
      quality of life related to the health were described in the people who had been
      affected by burns. MATERIALS AND METHODS: A cross-sectional descriptive study
      conducted in Medellin, Colombia, enrolled 130 people who suffered burns in the
      period 2001-2005. A standard quality-of-life survey consisting of 36 questions
      (the SF-36 scale) was administered. Statistical data were tested with Mann
      Whitney-U, Student-t, ANOVA, and Kruskal Wallis. Ethical considerations were met 
      within the framework of resolution 8430/93 of the Colombian Ministry of National 
      Health. RESULTS: The number of burns showed an increasing trend each year. Men
      were most often affected (66.9%) and severe burns were the most common (58%). The
      main burn sources were the fire flames, targeted attacks and gunpowder burns. The
      component of change of health upper obtained the average (55.3+/-19.2) and those 
      of emotional performance (30.2+/-42.9), and physical performance (31.1+/-43.6)
      lowest, finding significant differences in those of physical performance
      (p=0.039) and general health (p=0.034) according to burn degree. CONCLUSION: In
      spite some inconsistency, the most affected quality-of-life components were the
      physical and emotional performance, with an overall presentation of a low
      quality-of-life related to health.
FAU - Zapata, Dolly Marcela
AU  - Zapata DM
AD  - Departamento de Medicina Fisica y Rehabilitacion, Hospital Universitario San
      Vicente de Paul, Medellin, Colombia. dolly4056@gmail.com
FAU - Estrada, Alejandro
AU  - Estrada A
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
TT  - Calidad de vida relacionada con la salud de las personas afectadas por quemaduras
      despues de la cicatrizacion, Medellin, Colombia.
PL  - Colombia
TA  - Biomedica
JT  - Biomedica : revista del Instituto Nacional de Salud
JID - 8205605
SB  - IM
MH  - Adult
MH  - Burns/pathology/physiopathology/*psychology
MH  - Colombia
MH  - Cross-Sectional Studies
MH  - Female
MH  - *Health
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Quality of Life
MH  - Surveys and Questionnaires
MH  - *Wound Healing
EDAT- 2011/06/30 06:00
MHDA- 2011/10/25 06:00
CRDT- 2011/06/30 06:00
PHST- 2009/06/01 00:00 [received]
PHST- 2010/06/10 00:00 [accepted]
PHST- 2011/06/30 06:00 [entrez]
PHST- 2011/06/30 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
AID - S0120-41572010000400006 [pii]
PST - ppublish
SO  - Biomedica. 2010 Oct-Dec;30(4):492-500.


PMID- 21713333
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20110629
IS  - 2590-7379 (Electronic)
IS  - 0120-4157 (Linking)
VI  - 30
IP  - 3
DP  - 2010 Jul-Sep
TI  - Endophthalmitis by Pseudomonas aeruginosa. after penetrating keratoplasty, case
      report with an epidemiological investigation.
PG  - 327-31
LID - S0120-41572010000300004 [pii]
AB  - INTRODUCTION: An endophthalmitis following penetrating keratoplasty by
      Pseudomonas aeruginosa is a devasting case with very poor visual outcomes.
      OBJECTIVE: To determine the origin of an infection after a penetrating
      keratoplasty. MATERIALS AND METHODS: After an endophthalmitis an epidemiological 
      study was undertaken with the approval of the ethics committee and support of a
      medical team comprised of an epidemiologist, infectologist, bacteriologist and
      ophthalmologists specializing in cornea. Factors that may have contributed to the
      risk of infection were assessed, for example, the processing and preservation of 
      the cornea in the moment of the extraction, the characteristics of the donor,
      recipient and infecting bacterium, as well as the details pertaining to the
      surgical operation. RESULTS: No risks factors were found in the institution, in
      the eye bank facilities, in the donor or in the receptor. However, sterile
      technique could not be guaranteed in the morgue where the corneal extraction
      occurred, and other isolated cases of endophthalmitis post-keratoplasty had been 
      documented involving tissues from the same morgue that had been processed by two 
      eye banks in the same city. Characteristics of the multi-resistant Pseudomonas
      sp. demonstrated its origin from a hospital environment due to its previous
      exposure to a variety of antibiotics. CONCLUSIONS: Corneal extraction site must
      guarantee an antiseptic preparation and aseptic tissue donor recuperation;
      although in this study it was not feasible to accurately establish the infection 
      source, all of the findings led to suspect a possible contamination at the
      morgue.
FAU - Blanco, Claudia
AU  - Blanco C
AD  - Unidad de Cirugia de Cornea y Refractiva, Grupo de Investigacion Vision Sana,
      Clinica de Oftalmologia de Cali, Colombia.
FAU - Nunez, Maria X
AU  - Nunez MX
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Colombia
TA  - Biomedica
JT  - Biomedica : revista del Instituto Nacional de Salud
JID - 8205605
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Anti-Bacterial Agents/therapeutic use
MH  - Cornea/microbiology
MH  - Cross Infection/drug therapy/*etiology/*microbiology
MH  - Endophthalmitis/drug therapy/epidemiology/*etiology/*microbiology
MH  - Equipment Contamination
MH  - Eye Banks
MH  - Humans
MH  - Keratoplasty, Penetrating/*adverse effects
MH  - Male
MH  - Middle Aged
MH  - Postoperative Complications/drug therapy/etiology/*microbiology
MH  - Pseudomonas Infections/drug therapy/epidemiology/*microbiology
MH  - Risk Factors
EDAT- 2011/06/30 06:00
MHDA- 2011/10/25 06:00
CRDT- 2011/06/30 06:00
PHST- 2009/11/30 00:00 [received]
PHST- 2010/05/27 00:00 [accepted]
PHST- 2011/06/30 06:00 [entrez]
PHST- 2011/06/30 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
AID - S0120-41572010000300004 [pii]
PST - ppublish
SO  - Biomedica. 2010 Jul-Sep;30(3):327-31.


PMID- 21702245
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20110627
IS  - 0043-3144 (Print)
IS  - 0043-3144 (Linking)
VI  - 59
IP  - 6
DP  - 2010 Dec
TI  - Iatrogeny: why patients come to harm.
PG  - 702-5
AB  - latrogeny remains a constant challenge to all members of the health team who must
      be made aware from the onset of their roles and responsibility to their patients 
      with particular reference to patients' rights and well-being. Physicians, as the 
      acknowledged leaders of the health team, have the greatest role in this respect; 
      their training and involvement in supervising and monitoring members of their
      health teams must reflect an acknowledgement of this responsibility. The
      protection of the legacy associated with the medical profession for ethical
      behaviour and acting in the patient's best interest remains a challenge which
      must be addressed in the face of changing societal dynamics where rights and
      responsibilities are in a constant state of evolution. Medical schools must be at
      the forefront of responding to these challenges and reflect this by constant
      review of their training programmes.
FAU - Maharaj, S R
AU  - Maharaj SR
AD  - Department of Community Health and Psychiatry, The University of the West Indies,
      Kingston 7, Jamaica, West Indies. satnarine.maharaj@uwimona.edu.jm
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Jamaica
TA  - West Indian Med J
JT  - The West Indian medical journal
JID - 0417410
SB  - IM
MH  - Humans
MH  - *Iatrogenic Disease/prevention & control
MH  - Risk Factors
EDAT- 2011/06/28 06:00
MHDA- 2011/07/27 06:00
CRDT- 2011/06/28 06:00
PHST- 2011/06/28 06:00 [entrez]
PHST- 2011/06/28 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
AID - 1332 [pii]
PST - ppublish
SO  - West Indian Med J. 2010 Dec;59(6):702-5.


PMID- 21692267
OWN - NLM
STAT- MEDLINE
DCOM- 20110705
LR  - 20110620
IS  - 1330-0164 (Print)
IS  - 1330-0164 (Linking)
VI  - 64
IP  - 5
DP  - 2010 Dec
TI  - [Quality of health care, accreditation, and health technology assessment in
      Croatia: role of agency for quality and accreditation in health].
PG  - 425-34
AB  - Avedis Donabedian defined the quality of care as the kind of care, which is
      expected to maximize an inclusive measure of patient welfare, after taking into
      account the balance of expected gains and losses associated with the process of
      care in all its segments. According to the World Medical Assembly, physicians and
      health care institutions have an ethical and professional obligation to strive
      for continuous quality improvement of services and patient safety with the
      ultimate goal to improve both individual patient outcomes as well as population
      health. Health technology assessment (HTA) is a multidisciplinary process that
      summarizes information about the medical, social, economic and ethical issues
      related to the use of a health technology in a systematic, transparent, unbiased,
      robust manner, with the aim to formulate safe and effective health policies that 
      are patient focused and seek to achieve the highest value. The Agency for Quality
      and Accreditation in Health was established in 2007 as a legal, public,
      independent, nonprofit institution under the Act on Quality of Health Care. The
      Agency has three departments: Department of Quality and Education, Department of 
      Accreditation, and Department of Development, Research, and Health Technology
      Assessment. According to the Act, the Agency should provide the procedure of
      granting, renewal and cancellation of accreditation of healthcare providers;
      proposing to the Minister, in cooperation with professional associations, the
      plan and program for healthcare quality assurance, improvement, promotion and
      monitoring; proposing the healthcare quality standards as well as the
      accreditation standards to the Minister; keeping a register of accreditations and
      providing a database related to accreditation, healthcare quality improvement,
      and education; providing education in the field of healthcare quality assurance, 
      improvement and promotion; providing the HTA procedure and HTA database,
      supervising the healthcare insurance standards, and providing other services in
      the field of healthcare quality assurance, improvement, promotion and monitoring,
      according to the Act. Formal activities of the Agency in the field of HTA
      actually began in summer 2009. In the field of quality and accreditation, the
      plan and program of healthcare quality assurance, improvement, promotion and
      monitoring was finished and published in October 2010; preparation of the
      healthcare quality standards as well as the accreditation standards is still in
      process, with the aim to start accreditation process at 10 hospitals in 2011.
      Education in the field of healthcare quality assurance, improvement and promotion
      has been established as a continuous process from the beginning. The Agency is
      member of the International Society for Quality in Health Care (ISQua) and
      participates in the work of the European Accreditation Network (EAN). In the
      field of HTA, the Agency has established international collaboration and support,
      which resulted in its appointment and participation in the European network for
      Health Technology Assessment (EUnetHTA) Joint Action Project as a EUnetHTA
      Partner, as well as its membership in the international society, HTAi. TAIEX
      project has been approved as a two-day workshop in December 2010. The Croatian
      HTA Guidelines have been issued with the aim to start the HTA process and reports
      that should serve as recommendations, as a support to policy-makers at the
      national level, in particular the Croatian Ministry of Health and Social Welfare,
      and Croatian Institute of Health Insurance, in making evidence-informed decisions
      on the strategic planning, investment, management and implementation of
      technologies in health care, on funding (reimbursement) and coverage of health
      technologies, and at hospital level on the request from hospital directors and
      policy teams. In conclusion, establishment of all these measures in Croatia is by
      no means an easy and quick process, however, we do believe that it is feasible
      through continuous and close collaboration of all those involved.
FAU - Mittermayer, Renato
AU  - Mittermayer R
AD  - Agency for Quality and Accreditation in Health, Zagreb, Croatia.
      renato.mittermayer@aaz.hr
FAU - Huic, Mirjana
AU  - Huic M
FAU - Mestrovic, Josipa
AU  - Mestrovic J
LA  - hrv
PT  - English Abstract
PT  - Journal Article
TT  - Kvaliteta zdravstvene zastite, akreditacija nositelja zdravstvene djelatnosti i
      procjena zdravstvenih tehnologija u Hrvatskoj: uloga agencije za kv alitetu i
      akreditaciju u zdravstvu.
PL  - Croatia
TA  - Acta Med Croatica
JT  - Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti
JID - 9208249
SB  - IM
MH  - *Accreditation
MH  - Croatia
MH  - *Government Agencies
MH  - Humans
MH  - *Quality of Health Care
MH  - *Technology Assessment, Biomedical
EDAT- 2011/06/23 06:00
MHDA- 2011/07/06 06:00
CRDT- 2011/06/23 06:00
PHST- 2011/06/23 06:00 [entrez]
PHST- 2011/06/23 06:00 [pubmed]
PHST- 2011/07/06 06:00 [medline]
PST - ppublish
SO  - Acta Med Croatica. 2010 Dec;64(5):425-34.


PMID- 21688609
OWN - NLM
STAT- MEDLINE
DCOM- 20110705
LR  - 20110620
IS  - 1330-0164 (Print)
IS  - 1330-0164 (Linking)
VI  - 64
IP  - 4
DP  - 2010 Oct
TI  - [Palliative medicine--linkage of expert human care for the terminally ill and
      medical ethics].
PG  - 263-71
AB  - Palliative medicine is a new branch of medicine dealing with optimal quality of
      life and death, and is primarily a medical area of interest. Palliative care is a
      care provided by interdisciplinary palliative team. Let us remember that
      palliative care is a specific form of medical care for patients in the terminal
      phase of life. It is an approach to improve the quality of life of patients faced
      with fatal diseases, and of their families. Palliative care starts when classic
      methods of treatment have been exhausted, or when the symptoms of a malignant
      disease reach a level that the patient can hardly endure. It encompasses three
      areas: alleviating the symptoms, giving psycho-sociological support to patients
      and their caregivers, and dealing with ethical problems concerning the end of
      life. Particularly important is the ethics of palliative care, because it is
      focused on the aspects of care aimed at the patient and critical decision-making.
      The decisions made in palliative medicine require moral, legal and medical
      judgments. At the same time, one must strike a balance between clinical aspects
      of care and the patient's autonomy regarding his wishes, beliefs, and finally
      decisions about his own medical treatment. Ethical aspects of decision-making
      cannot be separated from clinical circumstances in the individual case, in the
      same way as medical decision-making cannot neglect the four (bio)ethical
      principles: beneficence, non-maleficence, autonomy of the person, and justice.
FAU - Brkljacic Zagrovic, Morana
AU  - Brkljacic Zagrovic M
AD  - Katedra za drustvene i humanisticke znanosti u medicini, Medicinski fakultet
      Sveucilista u Rijeci, Rijeka, Hrvatska. morana.brkljacic@medri.hr
LA  - hrv
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Palijativna medicina--spoj strucne humane skrbi za terminalno oboljele i
      medicinske etike.
PL  - Croatia
TA  - Acta Med Croatica
JT  - Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti
JID - 9208249
SB  - IM
MH  - Hospice Care/ethics
MH  - Humans
MH  - *Palliative Care/ethics/organization & administration
MH  - *Terminal Care/ethics
EDAT- 2011/06/22 06:00
MHDA- 2011/07/06 06:00
CRDT- 2011/06/22 06:00
PHST- 2011/06/22 06:00 [entrez]
PHST- 2011/06/22 06:00 [pubmed]
PHST- 2011/07/06 06:00 [medline]
PST - ppublish
SO  - Acta Med Croatica. 2010 Oct;64(4):263-71.


PMID- 21666741
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 1477-7509 (Print)
IS  - 1477-7509 (Linking)
VI  - 5
IP  - 2
DP  - 2010 Jun
TI  - Consenting futures: professional views on social, clinical and ethical aspects of
      information feedback to embryo donors in human embryonic stem cell research.
PG  - 77-85
AB  - This paper reports from an ongoing multidisciplinary, ethnographic study that is 
      exploring the views, values and practices (the ethical frameworks) drawn on by
      professional staff in assisted conception units and stem cell laboratories in
      relation to embryo donation for research purposes, particularly human embryonic
      stem cell (hESC) research, in the UK. We focus here on the connection between
      possible incidental findings and the circumstances in which embryos are donated
      for hESC research, and report some of the uncertainties and dilemmas of our staff
      participants. We explore the views of our study participants in relation to two
      themes: (1) rights to information and anticipating how donors might be informed
      about future research findings and (2) occupational work goals and trust.
FAU - Ehrich, Kathryn
AU  - Ehrich K
AD  - Centre for Biomedicine & Society, King's College London , Strand, London WC2R 2LS
      , UK.
FAU - Williams, Clare
AU  - Williams C
FAU - Farsides, Bobbie
AU  - Farsides B
LA  - eng
GR  - 086034/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PL  - England
TA  - Clin Ethics
JT  - Clinical ethics
JID - 101294546
PMC - PMC3104813
EDAT- 2011/06/15 06:00
MHDA- 2011/06/15 06:01
CRDT- 2011/06/14 06:00
PHST- 2011/06/14 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2011/06/15 06:01 [medline]
AID - 10.1258/ce.2009.009038 [doi]
AID - CE-09-38 [pii]
PST - ppublish
SO  - Clin Ethics. 2010 Jun;5(2):77-85. doi: 10.1258/ce.2009.009038.


PMID- 21631881
OWN - NLM
STAT- MEDLINE
DCOM- 20120626
LR  - 20120910
IS  - 1748-3743 (Electronic)
IS  - 1748-3735 (Linking)
VI  - 7
IP  - 1
DP  - 2012 Mar
TI  - The importance of 'approaching' older people: a grounded theory.
PG  - 29-36
LID - 10.1111/j.1748-3743.2010.00248.x [doi]
AB  - AIMS AND OBJECTIVES: The aim of this study was to identify and describe the
      ethical values in caring encounters as experienced by older patients in their
      daily interaction with nurses in wards for older people. BACKGROUND: Ethical
      values and morals are important aspects that influence the quality of care.
      METHODS: Empirical observational study including follow-up interviews. Twenty-two
      older patients participated voluntarily in this study. Constant comparative
      analysis, the core foundation of grounded theory was used. RESULTS: Five
      categories: being addressed, receiving respect, desiring to participate,
      increasing self-determination and gaining self-confidence formed the bases for
      the core category. APPROACHING: Approaching concerns how people become closer to 
      each other in a physical space. It also includes how people become closer to each
      other in a dialogue, involving verbal or bodily communication. CONCLUSIONS AND
      RELEVANCE TO CLINICAL PRACTICE: Approaching indicates the ethical values that
      guide nurses in their caring encounters with older patients. These values are
      noted by the patient and have an individual value as well as leading to improved 
      quality of their care. The older patient will be confident and satisfied with the
      caring encounter if the desired components in the nurse's approaching are
      exhibited.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Jonasson, Lise-Lotte
AU  - Jonasson LL
AD  - Department of Nursing Science, School of Health Sciences, University of
      Jonkoping, Sweden. lise-lotte.jonasson@hhj.hj.se
FAU - Bertero, Carina
AU  - Bertero C
LA  - eng
PT  - Journal Article
DEP - 20100830
PL  - England
TA  - Int J Older People Nurs
JT  - International journal of older people nursing
JID - 101267281
SB  - IM
MH  - Aged
MH  - Aging/psychology
MH  - Communication
MH  - Geriatric Nursing/*ethics/*methods/standards
MH  - Humans
MH  - Memory Disorders/nursing/psychology
MH  - *Morals
MH  - Nurse-Patient Relations/*ethics
MH  - Nursing Methodology Research
MH  - Nursing Staff/ethics/psychology/standards
MH  - Quality of Health Care
EDAT- 2011/06/03 06:00
MHDA- 2012/06/27 06:00
CRDT- 2011/06/03 06:00
PHST- 2011/06/03 06:00 [entrez]
PHST- 2011/06/03 06:00 [pubmed]
PHST- 2012/06/27 06:00 [medline]
AID - 10.1111/j.1748-3743.2010.00248.x [doi]
PST - ppublish
SO  - Int J Older People Nurs. 2012 Mar;7(1):29-36. doi:
      10.1111/j.1748-3743.2010.00248.x. Epub 2010 Aug 30.


PMID- 21627884
OWN - NLM
STAT- MEDLINE
DCOM- 20111004
LR  - 20110601
IS  - 1646-0758 (Electronic)
IS  - 0870-399X (Linking)
VI  - 23
IP  - 6
DP  - 2010 Nov-Dec
TI  - [Early intervention in psychosis: prepsychotic period].
PG  - 1083-90
AB  - Psychotic disorders, namely schizophrenia, are severe illnesses with their onset 
      in adolescence or youth adult age and have a classic limited outcome. In recent
      years there has been some research about early intervention in psychosis which
      can be done in prepsychotic period (prodrome) and/or after the onset of full
      blown psychotic episode. The authors review the literature about the diagnosis,
      evaluation, and possible interventions in patients in prepsychotic period
      (prodrome). Identification of patients with ultra high risk of psychosis could
      identify patients with a risk of development psychosis in 40%. The main
      interventions, pharmacological and psychosocial treatments, and main published
      studies are explained. Prospective identification of these patients and their
      treatment could prevent the development of full blown psychosis, delay the onset 
      or promote the recovery of the disorder. We must remember some ethical issues
      about this kind of intervention, namely the stigma and false positive
      individuals. The results from the research in this area are mainly preliminary,
      but these studies suggest that some interventions are effective and promising. In
      future we must have trials with more number of patients included and probably a
      refinement of the criteria of ultra high risk patients.
FAU - Coentre, Ricardo
AU  - Coentre R
AD  - Servico de Psiquiatria, Departamento de Neurociencias, Hospital de Santa
      Maria/Faculdade de Medicina de Lisboa, Lisbon.
FAU - Levy, Pedro
AU  - Levy P
FAU - Figueira, Maria Luisa
AU  - Figueira ML
LA  - por
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Intervencao precoce na psicose: periodo pre-psicotico.
DEP - 20101228
PL  - Portugal
TA  - Acta Med Port
JT  - Acta medica portuguesa
JID - 7906803
SB  - IM
MH  - Disease Progression
MH  - Early Diagnosis
MH  - Humans
MH  - Practice Guidelines as Topic
MH  - Psychotic Disorders/diagnosis/*therapy
EDAT- 2011/06/02 06:00
MHDA- 2011/10/05 06:00
CRDT- 2011/06/02 06:00
PHST- 2009/05/04 00:00 [received]
PHST- 2010/03/01 00:00 [accepted]
PHST- 2011/06/02 06:00 [entrez]
PHST- 2011/06/02 06:00 [pubmed]
PHST- 2011/10/05 06:00 [medline]
PST - ppublish
SO  - Acta Med Port. 2010 Nov-Dec;23(6):1083-90. Epub 2010 Dec 28.


PMID- 21627883
OWN - NLM
STAT- MEDLINE
DCOM- 20111004
LR  - 20181201
IS  - 1646-0758 (Electronic)
IS  - 0870-399X (Linking)
VI  - 23
IP  - 6
DP  - 2010 Nov-Dec
TI  - [Ethical, technical and legal procedures of the medical doctor responsibility to 
      accomplish the road enforcement law about driving under the influence of alcohol 
      and psychotropic substances].
PG  - 1059-82
AB  - The forensic toxicology (TF) is a science of analytical basis, aiming to clarify 
      legal issues related to poisoning, whether or not fatal, within the various areas
      of law (criminal, civil, labor, etc.). The analysis that are more often requested
      (with a tendency to increase and gaining rising attention) are those concerning
      the procedures involving supervision of driving under the influence of alcohol
      and psychotropic substances, in the living individual and in the cadaver. The key
      players in this process, are: (a) the police agents carrying out the screening
      and quantification of alcohol on the exhaled breath and the screening of
      psychotropic and stupefacient substances in saliva; (b) the public health
      services that perform qualitative analysis of these substances in urine (if the
      test was not previously performed in saliva); (c) the doctor that collects blood 
      samples from the living, or the dead victim; (d) the forensic toxicologist who
      conducts toxicological analysis in blood (or, eventually in another biological
      sample) and (e) the magistrate prosecutors that ultimately will receive the
      toxicological report to apply the law. Therefore it is important to understand
      and be acquainted with the road law enforcement of driving under the influence of
      alcohol and psychotropic substances, particularly in what concerns to the role of
      the medical doctor. Consequently, this paper aimed to review these topics, namely
      highlighting the necessary information to clarify the interested parties about
      the technical, ethical and legal procedures to consider.
FAU - Dinis-Oliveira, Ricardo Jorge
AU  - Dinis-Oliveira RJ
AD  - Faculdade de Medicina da Universidade do Porto, Porto.
FAU - Nunes, Rui
AU  - Nunes R
FAU - Carvalho, Felix
AU  - Carvalho F
FAU - Santos, Agostinho
AU  - Santos A
FAU - Teixeira, Helena
AU  - Teixeira H
FAU - Vieira, Duarte Nuno
AU  - Vieira DN
FAU - Magalhaes, Teresa
AU  - Magalhaes T
LA  - por
PT  - Journal Article
PT  - Review
TT  - Procedimentos tecnicos, eticos e legais da competencia do medico no cumprimento
      da lei da fiscalizacao da conducao rodoviaria sob influencia do alcool e
      substancias psicotropicas.
DEP - 20101228
PL  - Portugal
TA  - Acta Med Port
JT  - Acta medica portuguesa
JID - 7906803
RN  - 0 (Psychotropic Drugs)
SB  - IM
MH  - *Alcohol Drinking
MH  - Automobile Driving/*legislation & jurisprudence
MH  - Forensic Toxicology/*ethics/*legislation & jurisprudence
MH  - Humans
MH  - *Law Enforcement
MH  - Portugal
MH  - *Psychotropic Drugs
MH  - Records
EDAT- 2011/06/02 06:00
MHDA- 2011/10/05 06:00
CRDT- 2011/06/02 06:00
PHST- 2010/01/07 00:00 [received]
PHST- 2010/04/21 00:00 [accepted]
PHST- 2011/06/02 06:00 [entrez]
PHST- 2011/06/02 06:00 [pubmed]
PHST- 2011/10/05 06:00 [medline]
PST - ppublish
SO  - Acta Med Port. 2010 Nov-Dec;23(6):1059-82. Epub 2010 Dec 28.


PMID- 21625403
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 1050-8392 (Print)
IS  - 1050-8392 (Linking)
VI  - 20
IP  - 2
DP  - 2010 Jun 1
TI  - A Qualitative Assessment of South African Adolescents' Motivations For and
      Against Substance Use and Sexual Behavior.
PG  - 456-481
AB  - Focus groups (N = 15 groups; eight with girls, seven with boys) with adolescents 
      in high schools near Cape Town, South Africa were used to conduct a qualitative
      investigation of reported reasons for using and not using substances, and for
      having and not having sex. Adolescents reported Enhancement, Negative States,
      Social, and Aversive Social motivations for both substance use and sexual
      behavior. In addition, being addicted as a reason for using drugs and rape as a
      context for sexual behavior were frequently reported. Motivations against
      behaviors included Physical/Behavioral Consequences, Ethical Objections, Social
      Disapproval, and Activities or Future Orientation reasons. Preventive
      interventions should address existing motivations for and against substance use
      and sexual behavior to acknowledge adolescents' experiences in context.
FAU - Patrick, Megan E
AU  - Patrick ME
AD  - Institute for Social Research, University of Michigan, Ann Arbor, MI 48106-1248; 
      Phone 734-763-7107.
FAU - Palen, Lori-Ann
AU  - Palen LA
FAU - Caldwell, Linda
AU  - Caldwell L
FAU - Gleeson, Sarah
AU  - Gleeson S
FAU - Smith, Ed
AU  - Smith E
FAU - Wegner, Lisa
AU  - Wegner L
LA  - eng
GR  - F31 AA017014/AA/NIAAA NIH HHS/United States
GR  - T32 DA017629/DA/NIDA NIH HHS/United States
GR  - R01 DA017491-03/DA/NIDA NIH HHS/United States
GR  - T32 DA017629-02/DA/NIDA NIH HHS/United States
GR  - F31 AA017014-01/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - J Res Adolesc
JT  - Journal of research on adolescence : the official journal of the Society for
      Research on Adolescence
JID - 9109126
PMC - PMC3101481
MID - NIHMS290535
EDAT- 2011/06/01 06:00
MHDA- 2011/06/01 06:01
CRDT- 2011/06/01 06:00
PHST- 2011/06/01 06:00 [entrez]
PHST- 2011/06/01 06:00 [pubmed]
PHST- 2011/06/01 06:01 [medline]
AID - 10.1111/j.1532-7795.2010.00649.x [doi]
PST - ppublish
SO  - J Res Adolesc. 2010 Jun 1;20(2):456-481. doi: 10.1111/j.1532-7795.2010.00649.x.


PMID- 21600332
OWN - NLM
STAT- MEDLINE
DCOM- 20110815
LR  - 20191210
IS  - 0013-7006 (Print)
IS  - 0013-7006 (Linking)
VI  - 37 Suppl 1
DP  - 2011 May
TI  - [Patients' perception of seclusion in psychiatry: ethical perspectives].
PG  - S4-10
LID - 10.1016/j.encep.2010.04.013 [doi]
AB  - OBJECTIVE: Although seclusion is legally sanctioned in France, its use remains
      controversial, and debate continues over ethical and therapeutic aspects of the
      practice. Seclusion continues to be widely used in the management of disturbed
      behaviour in hospitalized patients. Although recent studies serve to strengthen
      the link between the use of seclusion and negative patient responses, they are
      limited in extending our understanding of the seclusion experience. The objective
      of this work was two-fold: to examine the perceptions and experiences of patients
      about their seclusion experience and then suggest ways of improving the use of
      seclusion in relation to an ethical perspective. METHOD: We conducted
      face-to-face semi-structured interviews with inpatients in a French Public
      Psychiatric Hospital, 3 weeks after their seclusion. They were conducted until no
      new ideas emerged in the content analysis, comprising 30 patients. Interviews
      were conducted using an interview guide by a physician. Specific attention was
      paid to their perceptions of seclusion. This guide was based on the concepts of
      medical ethics (autonomy, beneficence, non-malfeasance). Interviews were
      retranscribed and content analysis was performed by two of the authors who were
      skilled in textual analysis. Data analysis was performed using SPSS 15.0
      software. RESULTS: Autonomy was challenged by 50% of interviewed patients. For
      70% of patients, there was a lack of information and explanation during the
      seclusion on therapeutics, practices, procedures, expected length of time in
      seclusion and behaviours. This can contribute to perception of this process as
      punishment expressed by the patients. The dominant view of patients was that more
      effective communication about seclusion was needed. A majority of patients
      perceived the beneficence of the health professionals even if most of them did
      not express a benefit from this experience: only 26% believed that seclusion made
      them calm down and 36% that seclusion helped them to feel and behave better. The 
      level and the quality of the relationship with staff during and following the
      seclusion experience was a major source of satisfaction for patients and can
      counter-balance their negative perception of seclusion. The non-malfeasance was
      questioned by patients. The therapeutic value of seclusion was not recognized by 
      a majority of them. Seclusion from the patient's perspective appears to invoke a 
      complex range of feelings that include helplessness (76%), anger (60%),
      humiliation (60%), depression (50%), and fear (63%). For 60% of patients, the act
      of placing them in seclusion had a profound negative impact. Seventy-six percent 
      of them considered that seclusion could be prevented. CONCLUSION: Despite
      advances in our knowledge and understanding of mental illness, seclusion
      continues, and is likely to continue, as a treatment option for a number of
      patients. In our study, a certain number of trends were observed. Globally, there
      is some tension concerning ethical principles. Attention to the specific needs of
      patients while in seclusion may serve to reduce the punitive connotations linked 
      to the practice. What is needed is a permanent ethical reevaluation of seclusion.
      For this purpose, healthcare professional staffs may be useful for a truly
      ethical reflection. The aim is to recognize the patient as the agent of his/her
      own empowerment through appropriate information. This approach should not only
      provide the patient with the opportunity to understand why the seclusion
      occurred, but also some means for overcoming the negative effects of the
      procedure.
CI  - Copyright (c) 2010 L'Encephale, Paris. Published by Elsevier Masson SAS. All
      rights reserved.
FAU - Cano, N
AU  - Cano N
AD  - Pole psychiatrie centre, hopital La Conception, Assistance publique-Hopitaux de
      Marseille, 147, boulevard Baille, 13385 Marseille cedex 05, France.
      nicole.cano@ap-hm.fr
FAU - Boyer, L
AU  - Boyer L
FAU - Garnier, C
AU  - Garnier C
FAU - Michel, A
AU  - Michel A
FAU - Belzeaux, R
AU  - Belzeaux R
FAU - Chabannes, J-M
AU  - Chabannes JM
FAU - Samuelian, J-C
AU  - Samuelian JC
FAU - Harle, J-R
AU  - Harle JR
LA  - fre
PT  - Journal Article
TT  - L'isolement en psychiatrie: point de vue des patients et perspectives ethiques.
DEP - 20100629
PL  - France
TA  - Encephale
JT  - L'Encephale
JID - 7505643
SB  - IM
MH  - Adaptation, Psychological/ethics
MH  - Adult
MH  - Arousal/ethics
MH  - *Attitude
MH  - Beneficence
MH  - Crisis Intervention/ethics
MH  - Emotions/ethics
MH  - *Ethics, Medical
MH  - Female
MH  - France
MH  - Hospitals, Psychiatric/ethics
MH  - Humans
MH  - Interview, Psychological
MH  - Male
MH  - Patient Education as Topic/ethics
MH  - Patient Isolation/*ethics/*psychology
MH  - Patient Satisfaction
MH  - Personal Autonomy
MH  - Power, Psychological
MH  - Professional-Patient Relations/ethics
EDAT- 2011/05/28 06:00
MHDA- 2011/08/16 06:00
CRDT- 2011/05/24 06:00
PHST- 2009/11/05 00:00 [received]
PHST- 2010/03/10 00:00 [accepted]
PHST- 2011/05/24 06:00 [entrez]
PHST- 2011/05/28 06:00 [pubmed]
PHST- 2011/08/16 06:00 [medline]
AID - S0013-7006(10)00103-X [pii]
AID - 10.1016/j.encep.2010.04.013 [doi]
PST - ppublish
SO  - Encephale. 2011 May;37 Suppl 1:S4-10. doi: 10.1016/j.encep.2010.04.013. Epub 2010
      Jun 29.


PMID- 21607113
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1948-0210 (Electronic)
IS  - 1948-0210 (Linking)
VI  - 2
IP  - 2
DP  - 2010 Apr 26
TI  - Human pluripotent stem cells: from biology to cell therapy.
PG  - 24-33
LID - 10.4252/wjsc.v2.i2.24 [doi]
AB  - Human pluripotent stem cells (PSCs), encompassing embryonic stem cells and
      induced pluripotent stem cells, proliferate extensively and differentiate into
      virtually any desired cell type. PSCs endow regenerative medicine with an
      unlimited source of replacement cells suitable for human therapy. Several hurdles
      must be carefully addressed in PSC research before these theoretical
      possibilities are translated into clinical applications. These obstacles are: (1)
      cell proliferation; (2) cell differentiation; (3) genetic integrity; (4)
      allogenicity; and (5) ethical issues. We discuss these issues and underline the
      fact that the answers to these questions lie in a better understanding of the
      biology of PSCs. To contribute to this aim, we have developed a free online
      expression atlas, Amazonia!, that displays for each human gene a virtual northern
      blot for PSC samples and adult tissues (http://www.amazonia.transcriptome.eu).
FAU - Ramirez, Jean-Marie
AU  - Ramirez JM
AD  - Jean-Marie Ramirez, Qiang Bai, Marilyne Dijon-Grinand, Said Assou, Samir Hamamah,
      John De Vos, INSERM, U847, Montpellier, F 34000, France.
FAU - Bai, Qiang
AU  - Bai Q
FAU - Dijon-Grinand, Marilyne
AU  - Dijon-Grinand M
FAU - Assou, Said
AU  - Assou S
FAU - Gerbal-Chaloin, Sabine
AU  - Gerbal-Chaloin S
FAU - Hamamah, Samir
AU  - Hamamah S
FAU - De Vos, John
AU  - De Vos J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Stem Cells
JT  - World journal of stem cells
JID - 101535826
PMC - PMC3097919
OTO - NOTNLM
OT  - Cell differentiation
OT  - Cell proliferation
OT  - Cell reprogramming
OT  - Embryonic stem cells
OT  - Pluripotent stem cells
OT  - Therapeutics
EDAT- 2011/05/25 06:00
MHDA- 2011/05/25 06:01
CRDT- 2011/05/25 06:00
PHST- 2010/02/08 00:00 [received]
PHST- 2010/03/08 00:00 [revised]
PHST- 2010/03/15 00:00 [accepted]
PHST- 2011/05/25 06:00 [entrez]
PHST- 2011/05/25 06:00 [pubmed]
PHST- 2011/05/25 06:01 [medline]
AID - 10.4252/wjsc.v2.i2.24 [doi]
PST - ppublish
SO  - World J Stem Cells. 2010 Apr 26;2(2):24-33. doi: 10.4252/wjsc.v2.i2.24.


PMID- 21591828
OWN - NLM
STAT- MEDLINE
DCOM- 20110829
LR  - 20120302
IS  - 1037-6178 (Print)
IS  - 1037-6178 (Linking)
VI  - 37
IP  - 1
DP  - 2010 Dec-2011 Jan
TI  - The experiences of nurses in caring for circumcised initiates admitted to
      hospital with complications.
PG  - 69-81
LID - 10.5172/conu.2011.37.1.069 [doi]
AB  - The circumcision of males is a ritual that is performed in the veld, out of the
      public eye. Traditionally, it has to be attended by circumcised men only; no one 
      is allowed to see the initiates before they are officially released or
      discharged. In recent times, initiates have been admitted to hospitals following 
      complications during the circumcision process. In the hospitals, they are cared
      for by nurses. Hospitalisation of initiates creates problems for the elders who
      accompany the initiates as well as the nurses who are expected to care for them. 
      The purpose of the study was to explore and describe the experiences of nurses
      who care for initiates who have been admitted into hospital with medical and
      physical complications. A qualitative approach was adopted for this study, and
      the data was collected by means of unstructured interviews. A purposively
      selected sample of nurses of different categories from a rural hospital in the
      Nkangala district in Mpumalanga Province, South Africa, participated in the
      study. The data was analysed, and five major categories were developed. The major
      categories were: conflicting cultural practices, emotions, common complications, 
      ethical issues and possible solutions. Based on the findings of the study, it is 
      recommended that traditional circumcision should be regulated to avoid
      complications that lead to the admission of initiates into hospitals. Also, a
      collaborative partnership should be established between the health institutions
      and the traditional surgeons and healers in caring for initiates.
FAU - Mangena, Mack Phega
AU  - Mangena MP
AD  - University of Pretoria, Pretoria, South Africa.
FAU - Mulaudzi, Fhumulani Mavis
AU  - Mulaudzi FM
FAU - Peu, Mmapheko Doriccah
AU  - Peu MD
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Contemp Nurse
JT  - Contemporary nurse
JID - 9211867
MH  - Circumcision, Male/*adverse effects
MH  - Emotions
MH  - Ethics
MH  - Humans
MH  - Male
MH  - Nursing Staff, Hospital/*psychology
MH  - South Africa
EDAT- 2011/05/20 06:00
MHDA- 2011/08/30 06:00
CRDT- 2011/05/20 06:00
PHST- 2011/05/20 06:00 [entrez]
PHST- 2011/05/20 06:00 [pubmed]
PHST- 2011/08/30 06:00 [medline]
AID - 10.5172/conu.2011.37.1.069 [doi]
AID - 10.5172/conu.2011.37.1.069 [pii]
PST - ppublish
SO  - Contemp Nurse. 2010 Dec-2011 Jan;37(1):69-81. doi: 10.5172/conu.2011.37.1.069.


PMID- 21574344
OWN - NLM
STAT- MEDLINE
DCOM- 20110606
LR  - 20191112
IS  - 0102-6933 (Print)
IS  - 0102-6933 (Linking)
VI  - 31
IP  - 3
DP  - 2010 Sep
TI  - [A reflection upon an organizational system model for nursing care centered on
      best practices].
PG  - 562-6
AB  - This article aims at reflecting on nursing best practices and these practices as 
      a perspective of systemizing care. Quality of nursing becomes evident from
      management practices instituted as a result of its development throughout time.
      Thinkers of the management area have really influenced nursing both at
      professional acting and theoretical basis levels. It is imperative that nursing
      comes closer to best practices, which are considered as a non linear manner of
      perceiving the world, where structuring of its actions is centered on complex
      perspective; the use of registers as a way for planning organization and care to 
      take effect, as well as professional identification with issues that transcend
      personal care and are closer to universal ethics. Best practices are linked to
      social responsibility, sustainability and ecology as an essence of human actions 
      to conduct management practices.
FAU - Kempfer, Silvana Silveira
AU  - Kempfer SS
AD  - Programa de Pos-Graduacao em Enfermagem da Universidade Federal de Santa Catarina
      (UFSC), Florianopolis, Santa Catarina, Brasil. silvanakempfer@yahoo.com.br
FAU - Birolo, Iona Vieira Bez
AU  - Birolo IV
FAU - Meirelles, Betina Homer Schlindwein
AU  - Meirelles BH
FAU - Erdmann, Alacoque Lorenzini
AU  - Erdmann AL
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Reflexao sobre um modelo de sistema organizacional de cuidado de enfermagem
      centrado nas melhores praticas.
PL  - Brazil
TA  - Rev Gaucha Enferm
JT  - Revista gaucha de enfermagem
JID - 8504882
MH  - *Models, Organizational
MH  - Nursing/*organization & administration/*standards
EDAT- 2011/05/18 06:00
MHDA- 2011/06/07 06:00
CRDT- 2011/05/18 06:00
PHST- 2011/05/18 06:00 [entrez]
PHST- 2011/05/18 06:00 [pubmed]
PHST- 2011/06/07 06:00 [medline]
AID - 10.1590/s1983-14472010000300022 [doi]
PST - ppublish
SO  - Rev Gaucha Enferm. 2010 Sep;31(3):562-6. doi: 10.1590/s1983-14472010000300022.


PMID- 21574335
OWN - NLM
STAT- MEDLINE
DCOM- 20110606
LR  - 20191112
IS  - 0102-6933 (Print)
IS  - 0102-6933 (Linking)
VI  - 31
IP  - 3
DP  - 2010 Sep
TI  - [Perceptions of people about hypertension and concepts of Imogene King].
PG  - 499-507
AB  - As the discussion on cardiovascular diseases is a relevant matter, this paper
      aims to analyze the perceptions of a group of hypertensive people about their
      sickness process related to King's conceptual models of personal and
      interpersonal systems. This descriptive and exploitative study was developed in a
      reference unit in Fortaleza, Ceara, Brazil, accepted by the Ethics Committee of
      Ceara State University Fifty hypertensive people participated (34 women and 16
      men), ages 23 to 84. Results show fear of complications, satisfaction in adapting
      to treatment, dissatisfaction with the changes in their life style and
      resignation towards the disease. The nurse, seen as part of the initial
      assistance and in contrast with the insecurity shown by the patients, reveals the
      need of reflexion on the way patients are taken care.
FAU - Bezerra, Sara Taciana Firmino
AU  - Bezerra ST
AD  - Faculdade Metropolitana da Grande Fortaleza (FAMETRO), Fortaleza, Ceara, Brasil. 
      saratfb@yahoo.com.br
FAU - da Silva, Lucia de Fatima
AU  - da Silva Lde F
FAU - Guedes, Maria Vilani Cavalcante
AU  - Guedes MV
FAU - de Freitas, Maria Celia
AU  - de Freitas MC
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Percepcao de pessoas sobre a hipertensao arterial e conceitos de Imogene King.
PL  - Brazil
TA  - Rev Gaucha Enferm
JT  - Revista gaucha de enfermagem
JID - 8504882
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Attitude to Health
MH  - Female
MH  - Humans
MH  - Hypertension/*psychology
MH  - Male
MH  - Middle Aged
MH  - Models, Nursing
MH  - Nursing Theory
MH  - Young Adult
EDAT- 2011/05/18 06:00
MHDA- 2011/06/07 06:00
CRDT- 2011/05/18 06:00
PHST- 2011/05/18 06:00 [entrez]
PHST- 2011/05/18 06:00 [pubmed]
PHST- 2011/06/07 06:00 [medline]
AID - 10.1590/s1983-14472010000300013 [doi]
PST - ppublish
SO  - Rev Gaucha Enferm. 2010 Sep;31(3):499-507. doi: 10.1590/s1983-14472010000300013.


PMID- 21568063
OWN - NLM
STAT- MEDLINE
DCOM- 20110607
LR  - 20181201
IS  - 0017-7768 (Print)
IS  - 0017-7768 (Linking)
VI  - 149
IP  - 10
DP  - 2010 Oct
TI  - [The clinician-scientist: proposal for a new paradigm].
PG  - 661-4, 683
AB  - The decline in the attraction and prestige of the clinician-scientist paradigm is
      due to the dissonance between clinical work and conducting research in basic
      science. Medicine entails alleviating distress and prolonging life. Thus, medical
      research deals directly with the questions: what ails our patients and what
      shortens their lives? How can it be prevented? How can we alleviate suffering and
      prolong life? Research designs that fit these questions are: researcher (or
      patient) initiated randomized controlled trials; systematic reviews and
      meta-analysis; high-quality observational studies that address risk factors,
      natural history of disease, side-effects, and efficiency of treatment; research
      in ethics; and qualitative research. The clinician-scientist should perform
      medical research. Investing in this paradigm wilt encourage young doctors to
      conduct research directly oriented to benefit their patients.
FAU - Leibovici, Leonard
AU  - Leibovici L
AD  - Department of Medicine E, Beilinson-Tiqva. leibovic@post.tau.ac.il
FAU - Paul, Mical
AU  - Paul M
LA  - heb
PT  - Journal Article
PL  - Israel
TA  - Harefuah
JT  - Harefuah
JID - 0034351
SB  - IM
MH  - Biomedical Research/*organization & administration
MH  - Humans
MH  - Physicians/*organization & administration
MH  - Randomized Controlled Trials as Topic
MH  - Research Design
MH  - Research Personnel/*organization & administration
MH  - Workforce
EDAT- 2011/05/17 06:00
MHDA- 2011/06/08 06:00
CRDT- 2011/05/17 06:00
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2011/06/08 06:00 [medline]
PST - ppublish
SO  - Harefuah. 2010 Oct;149(10):661-4, 683.


PMID- 21568056
OWN - NLM
STAT- MEDLINE
DCOM- 20110607
LR  - 20151119
IS  - 0017-7768 (Print)
IS  - 0017-7768 (Linking)
VI  - 149
IP  - 10
DP  - 2010 Oct
TI  - [Oocytes cryopreservation: in which circumstances? Who should pay? Approaches
      amongst attending IVF physicians and researchers in the field of bioethics and
      health regulation].
PG  - 630-4, 685
AB  - BACKGROUND: In recent years there have been significant advances in the process
      of oocyte cryopreservation. Advanced techniques including vitrification have seen
      increasing success rates of fertilization. These successes warrant renewed public
      consideration and debate on several issues: In what circumstances? Who should
      pay? How should the process be regulated? STUDY QUESTION: Our goals were to
      examine the approach to oocyte cryopreservation amongst attending in-vitro
      fertilization (IVF) physicians and amongst researchers in the field of bioethics 
      and health regulation. METHODS: Questionnaires regarding egg freezing were given 
      to physicians heading IVF departments in Israel, and to bioethics researchers /
      health care administrators. RESULTS: Among the two groups questioned, there is
      strong support (80%) for the freezing of oocytes for personal circumstances,
      which may not be purely medical. Despite this support, there appears to be a
      difference in reasoning for this support. While most physicians see no reason to 
      inhibit using the technology, bioethicists attend to the conflict between
      personal liberties and potentially troubling ethical consequences on society when
      utilizing these technologies. There is an additional discrepancy between the
      groups concerning regulation. Physicians prefer regulation by administrative
      means, while bioethicists would prefer regulation by Laws. CONCLUSIONS: Despite
      widespread support of oocyte cryopreservation for personal reasons among the two 
      groups questioned, their views arise from different rationales. implementation of
      egg freezing technologies requires careful interdisciplinary discussion in order 
      to consider the various medical, ethical, and sociological factors that these
      technologies will incur.
FAU - Malkiel, Avishay
AU  - Malkiel A
AD  - Department of Obstetrics and Gynecology Shaare Zedek Medical Center.
      malkiel.avishay@gmail.com
FAU - Chinitz, David
AU  - Chinitz D
FAU - Lehmann, Lisa Soleymani
AU  - Lehmann LS
FAU - Brezis, Mayer
AU  - Brezis M
LA  - heb
PT  - English Abstract
PT  - Journal Article
PL  - Israel
TA  - Harefuah
JT  - Harefuah
JID - 0034351
SB  - IM
MH  - Attitude of Health Personnel
MH  - *Bioethical Issues
MH  - Cryopreservation/economics/ethics/*methods
MH  - Female
MH  - Fertilization in Vitro/economics/ethics/*methods
MH  - Humans
MH  - Israel
MH  - *Oocytes
MH  - Physicians/ethics/psychology
MH  - Surveys and Questionnaires
EDAT- 2011/05/17 06:00
MHDA- 2011/06/08 06:00
CRDT- 2011/05/17 06:00
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2011/06/08 06:00 [medline]
PST - ppublish
SO  - Harefuah. 2010 Oct;149(10):630-4, 685.


PMID- 21568052
OWN - NLM
STAT- MEDLINE
DCOM- 20110719
LR  - 20110512
IS  - 0001-4079 (Print)
IS  - 0001-4079 (Linking)
VI  - 194
IP  - 4-5
DP  - 2010 Apr-May
TI  - [Tomorrow, who will take care of the elderly? The oldest old support ratio].
PG  - 793-801; discussion 801-4
AB  - The 1998 report on Aging by the French National Ethical Advisory Committee stated
      that: "human life expectancy is increasing at its fastest rate in history".
      Professor Denys Pellerin, one of the rapporteurs, stressed the problems this
      would pose in coming years. More than 10 years later, these forecasts have been
      confirmed and new emerging problems call for further reflection. In particular,
      the place of informal caregivers needs to be reevaluated. This article examines
      informal caregivers' involvement in the care of the oldest-old and dependent
      adults in France, and the implications of the ongoing reduction in their numbers.
      Intergenerational links are examined, along with differences between
      chronological and functional age, chronic health impairments and disabilities in 
      daily living. The large number of people over 75 years of age, and their
      difficult living conditions, underline the importance of informal caregivers. In 
      France, in the 1950s, the oldest-old support ratio (OOSR) between persons aged 50
      to 75 years and persons over 85 years was 45 to 1. In 2050 the OOSR is likely to 
      be closer to 5 to 1! This trend will have important consequences for home care,
      which is widely considered to be the best way of preserving human dignity, as
      underlined by Professor Maurice Tubiana in a 2005 report on "Social insertion of 
      the elderly at home ". While homecare is the most economic form of care, it also 
      appears to be the most difficult to maintain and develop. Possible solutions
      include:--Better integration of old age within the human life cycle--Recognizing 
      and supporting informal caregivers' excellent work--Maintaining adequate numbers 
      of community-based healthcare professionals--Providing caregivers and healthcare 
      professionals with specific training--Developing new and financially attractive
      care programs.
FAU - Michel, Jean-Pierre
AU  - Michel JP
AD  - Geriatrie, Hopitaux universitaires de Geneve-Suisse, 40A route de Malagou 1208
      Geneve-Suisse. jean-pierre.michel@hcuge.ch
FAU - Robine, Jean-Marie
AU  - Robine JM
FAU - Herrmann, Francois
AU  - Herrmann F
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Demain, qui va prendre soin des personnes agees? Le taux de soutien aux tres
      ages.
PL  - Netherlands
TA  - Bull Acad Natl Med
JT  - Bulletin de l'Academie nationale de medecine
JID - 7503383
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Caregivers
MH  - Female
MH  - Forecasting
MH  - France
MH  - Health Services for the Aged/*statistics & numerical data/trends
MH  - Humans
MH  - Male
MH  - Social Support
EDAT- 2011/05/17 06:00
MHDA- 2011/07/20 06:00
CRDT- 2011/05/17 06:00
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2011/07/20 06:00 [medline]
PST - ppublish
SO  - Bull Acad Natl Med. 2010 Apr-May;194(4-5):793-801; discussion 801-4.


PMID- 21568045
OWN - NLM
STAT- MEDLINE
DCOM- 20110719
LR  - 20110512
IS  - 0001-4079 (Print)
IS  - 0001-4079 (Linking)
VI  - 194
IP  - 4-5
DP  - 2010 Apr-May
TI  - [Consequences of opposition to vaccination in France and Europe. How to maintain 
      effective vaccine coverage in 2010?].
PG  - 719-32; discussion 732
AB  - Refusal of vaccination can result in inadequate vaccine coverage. The collective 
      benefit of immunisation depends on a sufficient and sustained level of vaccine
      coverage. Low vaccine coverage can lead to the persistence of preventable
      diseases and, in some cases, to a dangerous shift in the age of pathogen
      encounter towards adulthood. This is the case of measles in Europe, where some
      countries, including France, have not reached the effective vaccine coverage rate
      of 95%. Outbreaks are occurring, leading to complications (encephalitis and
      pneumonia) in adolescents and adults, necessitating hospitalization in nearly
      one-third of cases. The French population is also under-vaccinated against
      hepatitis B, due to fears of a risk of demyelinating disorders: the coverage rate
      is currently only about 30% in infants and 10% in adolescents. These difficulties
      are due to negligence and to vaccine refusal by parents. Refusal of immunisation 
      has a long history in Europe, and explains for example why pertussis remained
      endemic in many countries until 1995, and also the resurgence of diphtheria in
      the Russian federation during the 1990s. Sections of Western society are now
      questioning the need for some routine vaccines, overlooking the fact that they
      have eradicated some diseases (polio, diphtheria, etc.) and protect effectively
      against lesser-known pathogens such as hepatitis B virus and HPV. In France, it
      will be necessary to restructure healthcare professional training programs in
      vaccinology and to provide the public with more thorough information on the
      risk-benefit ratio of vaccination. The recent controversy surrounding pandemic
      H1N1 influenza vaccination demonstrates that the public and the media tend to
      focus more on the potential risks of vaccination than on its benefits. A vigorous
      ethical and political debate is needed to shape an effective and acceptable
      vaccine policy for the 21st century.
FAU - Begue, Pierre
AU  - Begue P
AD  - pbegue@wanadoo.fr
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Consequences des oppositions vaccinales en France et en Europe. Comment maintenir
      une couverture vaccinale efficace en 2010?
PL  - Netherlands
TA  - Bull Acad Natl Med
JT  - Bulletin de l'Academie nationale de medecine
JID - 7503383
SB  - IM
MH  - Communicable Disease Control
MH  - Europe
MH  - France
MH  - Humans
MH  - *Treatment Refusal
MH  - *Vaccination/adverse effects
EDAT- 2011/05/17 06:00
MHDA- 2011/07/20 06:00
CRDT- 2011/05/17 06:00
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2011/07/20 06:00 [medline]
PST - ppublish
SO  - Bull Acad Natl Med. 2010 Apr-May;194(4-5):719-32; discussion 732.


PMID- 21567821
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20110513
IS  - 1539-3429 (Electronic)
IS  - 1470-8175 (Linking)
VI  - 38
IP  - 3
DP  - 2010 May
TI  - Designing laboratory exercises for the undergraduate molecular
      biology/biochemistry student: Techniques and ethical implications involved in
      personalized medicine.
PG  - 180-7
LID - 10.1002/bmb.20366 [doi]
AB  - Personalized medicine refers to medical care that involves genetically screening 
      patients for their likelihood to develop various disorders. Commercial genome
      screening only involves identifying a consumer's genotype for a few single
      nucleotide polymorphisms. A phenotype (such as an illness) is greatly influenced 
      by three factors: genes, gene expression levels, and the environment. The
      information supplied by personal genomics companies only involves genes and as
      such is not always indicative of a particular phenotype. Here, we propose a
      method for developing modular undergraduate laboratories that examine each
      contributing factor for a single gene. Although each module is suitable as an
      individual laboratory exercise, every module may be used in the same class to
      examine a single phenotype of interest, give students a more complete
      understanding of how a phenotype is produced and allow students to understand the
      science behind personalized medicine.
CI  - Copyright (c) 2010 International Union of Biochemistry and Molecular Biology,
      Inc.
FAU - Weinlander, Kenneth M
AU  - Weinlander KM
AD  - Chemistry Department, Lawrence University, Appleton, Wisconsin 54911.
FAU - Hall, David J
AU  - Hall DJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Biochem Mol Biol Educ
JT  - Biochemistry and molecular biology education : a bimonthly publication of the
      International Union of Biochemistry and Molecular Biology
JID - 100970605
EDAT- 2011/05/14 06:00
MHDA- 2011/05/14 06:01
CRDT- 2011/05/14 06:00
PHST- 2011/05/14 06:00 [entrez]
PHST- 2011/05/14 06:00 [pubmed]
PHST- 2011/05/14 06:01 [medline]
AID - 10.1002/bmb.20366 [doi]
PST - ppublish
SO  - Biochem Mol Biol Educ. 2010 May;38(3):180-7. doi: 10.1002/bmb.20366.


PMID- 21564149
OWN - NLM
STAT- MEDLINE
DCOM- 20110901
LR  - 20110513
IS  - 1471-6712 (Electronic)
IS  - 0283-9318 (Linking)
VI  - 25
IP  - 2
DP  - 2011 Jun
TI  - The impact of bodily change on social behaviour in patients with
      thyroid-associated ophthalmopathy.
PG  - 341-9
LID - 10.1111/j.1471-6712.2010.00832.x [doi]
AB  - Thyroid-associated ophthalmopathy (TAO) is characterized by the altered
      appearance of face and eyes and changed visual function. TAO has been described
      as alarming and crippling. It is well documented that TAO influences the
      patient's quality of life negatively. However, little is known about how the
      bodily change complicates the patient's social behaviour in everyday situations. 
      The aim of this study was to explore how social behaviour is influenced by the
      bodily change and what it means to patients with TAO. An ethnographic study was
      conducted using in-depth interviews and participant observation. A total of 13
      patients, nine women and four men, diagnosed with moderate to severe TAO were
      included. Data analysis was performed concurrently using grounded theory
      technique. The local ethics committee approved the study, and all participants
      gave written informed consent. The study reveals that the experience of bodily
      change had considerable consequences for patients' involvement with people and
      maintenance of social relations. Uncontrollable eyes were the dominating
      experience. It contained four sub-themes; the experience of changed facial
      communication, the experience of being somebody else, the experience of being
      clumsy among others and the experience of being cut off from the outside world.
      The bodily change affected people's attitude and behaviour towards them and their
      own ways of being with people. They struggled to change social behaviour and
      avoid withdrawal. In their struggle, they used seven different coping strategies.
      The study contributes to clarification of essential aspects of living with TAO.
      The condition of uncontrollable eyes may have serious consequences for patients' 
      social behaviour and relationships with others. Early identification of the
      impact of bodily change and planned support may help prevent serious quality of
      life change.
CI  - (c) 2010 The Authors. Scandinavian Journal of Caring Sciences (c) 2010 Nordic
      College of Caring Science.
FAU - Jensen, Annesofie L
AU  - Jensen AL
AD  - Department of Endocrinology and Metabolism, Aarhus University Hospital, Aarhus
      Hospital, Aarhus, Denmark. annesjen@rm.dk
FAU - Harder, Ingegerd
AU  - Harder I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100924
PL  - Sweden
TA  - Scand J Caring Sci
JT  - Scandinavian journal of caring sciences
JID - 8804206
MH  - Female
MH  - Graves Ophthalmopathy/*psychology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Social Behavior
EDAT- 2011/05/14 06:00
MHDA- 2011/09/02 06:00
CRDT- 2011/05/14 06:00
PHST- 2011/05/14 06:00 [entrez]
PHST- 2011/05/14 06:00 [pubmed]
PHST- 2011/09/02 06:00 [medline]
AID - 10.1111/j.1471-6712.2010.00832.x [doi]
PST - ppublish
SO  - Scand J Caring Sci. 2011 Jun;25(2):341-9. doi: 10.1111/j.1471-6712.2010.00832.x. 
      Epub 2010 Sep 24.


PMID- 21553555
OWN - NLM
STAT- MEDLINE
DCOM- 20110524
LR  - 20170214
IS  - 0306-3127 (Print)
IS  - 0306-3127 (Linking)
VI  - 40
IP  - 6
DP  - 2010 Dec
TI  - Adverse events and placebo effects: African scientists, HIV, and ethics in the
      'global health sciences'.
PG  - 843-70
AB  - This paper builds on the growing literature in 'postcolonial technoscience' by
      examining how science and ethics travel in transnational HIV research. I use
      examples of two controversial US-funded studies of mother-to-child transmission
      in Africa as case studies through which to explore quandaries of difference and
      inequality in global health research. My aim is not to adjudicate the debates
      over these studies, but rather to raise some questions about transnational
      research, science, and ethics that often get lost in public controversies over
      the moral status of such trials. Using interviews conducted with American and
      Ugandan HIV researchers as well as relevant material published in the popular and
      medical press, I argue that debates over research practice and the conditions
      under which practices are deemed ethically legitimate or questionable reflect the
      challenges faced by African researchers seeking to participate in global health
      science. In doing so, I show how questions of scientific legitimacy and authority
      are played out in debates over who decides what constitutes 'the normal' in human
      biological research and who can legitimately 'speak for Africa' regarding the
      ethics of research design and practice. I conclude that researchers
      from'resource-poor settings' must often walk a tightrope between claims of
      difference from the global North and assertions of sameness, in which a claim too
      forceful in either direction can undermine the ethical--and thus
      scientific--legitimacy of their research.
FAU - Crane, Johanna
AU  - Crane J
AD  - University of Washington--Bothell, 18115 Campus Way NE, Bothell, WA 98011, USA.
      johcrane@yahoo.com
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Soc Stud Sci
JT  - Social studies of science
JID - 7506743
RN  - 0 (Reverse Transcriptase Inhibitors)
RN  - 4B9XT59T7S (Zidovudine)
MH  - Africa
MH  - *Biomedical Research/ethics/organization & administration
MH  - *Clinical Trials as Topic/ethics
MH  - *Ethics, Research
MH  - Female
MH  - Global Health
MH  - HIV Infections/drug therapy/transmission
MH  - Humans
MH  - Infectious Disease Transmission, Vertical
MH  - National Institutes of Health (U.S.)
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious
MH  - Reverse Transcriptase Inhibitors/therapeutic use
MH  - Therapeutic Human Experimentation/ethics
MH  - United States
MH  - Zidovudine/therapeutic use
EDAT- 2011/05/11 06:00
MHDA- 2011/05/25 06:00
CRDT- 2011/05/11 06:00
PHST- 2011/05/11 06:00 [entrez]
PHST- 2011/05/11 06:00 [pubmed]
PHST- 2011/05/25 06:00 [medline]
AID - 10.1177/0306312710371145 [doi]
PST - ppublish
SO  - Soc Stud Sci. 2010 Dec;40(6):843-70. doi: 10.1177/0306312710371145.


PMID- 21552512
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 0958-2029 (Print)
IS  - 0958-2029 (Linking)
VI  - 19
IP  - 4
DP  - 2010 Oct 1
TI  - Integrating utilization-focused evaluation with business process modeling for
      clinical research improvement.
PG  - 239-250
AB  - New discoveries in basic science are creating extraordinary opportunities to
      design novel biomedical preventions and therapeutics for human disease. But the
      clinical evaluation of these new interventions is, in many instances, being
      hindered by a variety of legal, regulatory, policy and operational factors, few
      of which enhance research quality, the safety of study participants or research
      ethics. With the goal of helping increase the efficiency and effectiveness of
      clinical research, we have examined how the integration of utilization-focused
      evaluation with elements of business process modeling can reveal opportunities
      for systematic improvements in clinical research. Using data from the NIH global 
      HIV/AIDS clinical trials networks, we analyzed the absolute and relative times
      required to traverse defined phases associated with specific activities within
      the clinical protocol lifecycle. Using simple median duration and Kaplan-Meyer
      survival analysis, we show how such time-based analyses can provide a rationale
      for the prioritization of research process analysis and re-engineering, as well
      as a means for statistically assessing the impact of policy modifications,
      resource utilization, re-engineered processes and best practices. Successfully
      applied, this approach can help researchers be more efficient in capitalizing on 
      new science to speed the development of improved interventions for human disease.
FAU - Kagan, Jonathan M
AU  - Kagan JM
AD  - Division of Clinical Research, NIAID/NIH, 6700 B Rockledge Drive, Room 1102, MSC 
      7609, Bethesda, MD 20892-7609, USA.
FAU - Rosas, Scott
AU  - Rosas S
FAU - Trochim, William M K
AU  - Trochim WM
LA  - eng
GR  - UL1 RR024996/RR/NCRR NIH HHS/United States
GR  - N01AI50022/AI/NIAID NIH HHS/United States
GR  - N01 AI030060-11/AI/NIAID NIH HHS/United States
GR  - N01AI30020/AI/NIAID NIH HHS/United States
GR  - UL1 RR024996-01/RR/NCRR NIH HHS/United States
GR  - N01 AI050022/AI/NIAID NIH HHS/United States
PT  - Journal Article
PL  - England
TA  - Res Eval
JT  - Research Evaluation
JID - 9884634
PMC - PMC3087184
MID - NIHMS258700
EDAT- 2011/05/10 06:00
MHDA- 2011/05/10 06:01
CRDT- 2011/05/10 06:00
PHST- 2011/05/10 06:00 [entrez]
PHST- 2011/05/10 06:00 [pubmed]
PHST- 2011/05/10 06:01 [medline]
AID - 10.3152/095820210X12827366906607 [doi]
PST - ppublish
SO  - Res Eval. 2010 Oct 1;19(4):239-250. doi: 10.3152/095820210X12827366906607.


PMID- 21550463
OWN - NLM
STAT- MEDLINE
DCOM- 20110908
LR  - 20220317
IS  - 1527-2966 (Electronic)
IS  - 0099-1767 (Linking)
VI  - 37
IP  - 3
DP  - 2011 May
TI  - An Australian audit of ED pain management patterns.
PG  - 269-74
LID - 10.1016/j.jen.2010.03.007 [doi]
AB  - INTRODUCTION: Timely and appropriate pain management is an important quality
      indicator of ED performance. Emergency health care workers are well positioned to
      become active leaders and innovatively responsive in reducing human suffering. A 
      pain management audit was conducted to determine Australia practice patterns.
      METHODS: A 12-month retrospective descriptive cohort audit was undertaken.
      Through the randomization process a medical record audit tool was completed for
      each record identified. Ethical approval for the study was obtained. RESULTS:
      Seventy-four hospitals agreed to conduct the audit, 36 (48%) provided data. The
      total number of patient notes reviewed was 2,066. Ninety-five percent (1,966) of 
      patients arrived by ambulance. Of the patients (n=547; 56.4%) with a documented
      triage pain score the majority arrived in severe pain (n=300; 41.3%). Of the
      total number of patients (1,966) documented arriving in pain 1,473 (74.9%)
      received an analgesic. Six hundred and forty-four (32.7%) patients received an
      opioid. From time of emergency department arrival, the median time for analgesic 
      administration was 70 minutes (IQR 58 minutes to 92 minutes). Twenty-five
      emergency departments (69.4%) had pain management policies that enabled nurses to
      initiate a pharmacological analgesia without medical consultation. DISCUSSION:
      The Australian pain management audit highlighted current practices and potential 
      areas for further research. While the audit demonstrated that nurse initiated
      pain management interventions promoted better analgesic response, greater
      consistency of triage pain assessment, code allocation, and documentation of pain
      scores may go some way to improving the timeliness of analgesia.
CI  - Copyright (c) 2011 Emergency Nurses Association. Published by Mosby, Inc. All
      rights reserved.
FAU - Fry, Margaret
AU  - Fry M
AD  - Faculty of Nursing, Midwifery and Health, University of Technology, Sydney,
      Australia. margaret.fry@uts.edu.au
FAU - Bennetts, Scott
AU  - Bennetts S
FAU - Huckson, Sue
AU  - Huckson S
LA  - eng
PT  - Journal Article
DEP - 20100418
PL  - United States
TA  - J Emerg Nurs
JT  - Journal of emergency nursing
JID - 7605913
MH  - Australia
MH  - Clinical Nursing Research
MH  - Emergency Nursing
MH  - Emergency Service, Hospital/*standards
MH  - Humans
MH  - Medical Audit
MH  - *Pain Management
MH  - Pain Measurement
MH  - *Quality Indicators, Health Care
MH  - Triage
EDAT- 2011/05/10 06:00
MHDA- 2011/09/09 06:00
CRDT- 2011/05/10 06:00
PHST- 2009/06/16 00:00 [received]
PHST- 2010/03/15 00:00 [revised]
PHST- 2010/03/15 00:00 [accepted]
PHST- 2011/05/10 06:00 [entrez]
PHST- 2011/05/10 06:00 [pubmed]
PHST- 2011/09/09 06:00 [medline]
AID - S0099-1767(10)00114-5 [pii]
AID - 10.1016/j.jen.2010.03.007 [doi]
PST - ppublish
SO  - J Emerg Nurs. 2011 May;37(3):269-74. doi: 10.1016/j.jen.2010.03.007. Epub 2010
      Apr 18.


PMID- 21540617
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20110531
IS  - 1423-0305 (Electronic)
IS  - 1016-2291 (Linking)
VI  - 46
IP  - 6
DP  - 2010
TI  - Commentary on 'quality of life and myelomeningocele: an ethical and
      evidence-based analysis of the Groningen Protocol' by Sean Barry, Pediatr
      Neurosurg 2010;46:409-414.
PG  - 415-6
LID - 10.1159/000325152 [doi]
FAU - Aronin, Patricia A
AU  - Aronin PA
FAU - George, Timothy M
AU  - George TM
LA  - eng
PT  - Comment
PT  - Editorial
DEP - 20110503
PL  - Switzerland
TA  - Pediatr Neurosurg
JT  - Pediatric neurosurgery
JID - 9114967
SB  - IM
CON - Pediatr Neurosurg. 2010;46(6):409-14. PMID: 21540616
MH  - Euthanasia, Active/*ethics/methods
MH  - Evidence-Based Medicine/*ethics
MH  - Humans
MH  - Infant, Newborn
MH  - *Meningomyelocele
MH  - *Quality of Life
EDAT- 2011/05/05 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/05/05 06:00
PHST- 2011/01/11 00:00 [received]
PHST- 2011/02/02 00:00 [accepted]
PHST- 2011/05/05 06:00 [entrez]
PHST- 2011/05/05 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - 000325152 [pii]
AID - 10.1159/000325152 [doi]
PST - ppublish
SO  - Pediatr Neurosurg. 2010;46(6):415-6. doi: 10.1159/000325152. Epub 2011 May 3.


PMID- 21540616
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20110531
IS  - 1423-0305 (Electronic)
IS  - 1016-2291 (Linking)
VI  - 46
IP  - 6
DP  - 2010
TI  - Quality of life and myelomeningocele: an ethical and evidence-based analysis of
      the Groningen Protocol.
PG  - 409-14
LID - 10.1159/000322895 [doi]
AB  - In 2005, a group of pediatricians at the University Medical Center in Groningen, 
      The Netherlands, published the Groningen Protocol (GP) for Euthanasia in
      Newborns. This protocol is a set of guidelines devised in 2001 to clarify and
      facilitate the assessment of clinically stable neonates deemed to be in
      unbearable suffering for whom the prognosis is felt to be hopeless. At the time
      of publication, the GP had been in use for 7 years, and 22 patients, all with
      diagnosed myelomeningocele (MMC), had met the selection criteria for euthanasia
      by lethal injection. MMC is the most common neurological congenital anomaly,
      affecting approximately 300,000 newborns yearly worldwide. Neurosurgeons have a
      unique perspective on this disease and therefore an important voice, given the
      significant role they have in caring for these patients at all stages of their
      lives. This paper reviews the principal ethical arguments presented to date in
      the literature regarding the GP. It also provides an evidence-based critique of
      the GP in light of quality-of-life studies addressing adults with MMC, and
      ascertains whether or not the GP meets the criteria for an evidence-based
      guideline.
CI  - Copyright (c) 2011 S. Karger AG, Basel.
FAU - Barry, Sean
AU  - Barry S
AD  - Center for Biomedical Ethics and Law, KU Leuven, Leuven, Belgium. spbarry@dal.ca
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110503
PL  - Switzerland
TA  - Pediatr Neurosurg
JT  - Pediatric neurosurgery
JID - 9114967
SB  - IM
CIN - Pediatr Neurosurg. 2010;46(6):415-6. PMID: 21540617
MH  - Euthanasia, Active/*ethics/methods
MH  - Evidence-Based Medicine/*ethics
MH  - Humans
MH  - Infant, Newborn
MH  - *Meningomyelocele
MH  - Netherlands
MH  - Pain/*prevention & control
MH  - *Quality of Life
EDAT- 2011/05/05 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/05/05 06:00
PHST- 2010/08/30 00:00 [received]
PHST- 2010/11/06 00:00 [accepted]
PHST- 2011/05/05 06:00 [entrez]
PHST- 2011/05/05 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - 000322895 [pii]
AID - 10.1159/000322895 [doi]
PST - ppublish
SO  - Pediatr Neurosurg. 2010;46(6):409-14. doi: 10.1159/000322895. Epub 2011 May 3.


PMID- 21539714
OWN - NLM
STAT- MEDLINE
DCOM- 20110901
LR  - 20110504
IS  - 1748-3743 (Electronic)
IS  - 1748-3735 (Linking)
VI  - 6
IP  - 2
DP  - 2011 Jun
TI  - Experiences of relocation in dementia care from the perspective of six care
      workers.
PG  - 93-101
LID - 10.1111/j.1748-3743.2010.00246.x [doi]
AB  - BACKGROUND: Relocation of persons with dementia might be considered when quality 
      of care cannot be sustained due to increasing needs. Relocation has been studied 
      from the aspects of mortality and morbidity. AIM. To explore the thoughts and
      experiences of care workers when relocating a person with dementia within
      municipal sheltered housing. METHOD: This qualitative study was conducted in
      Sweden and based on interviews with six care workers involved in the relocation
      of two persons with dementia. Latent content analysis was applied. RESULTS: The
      findings of one narrative are summarised in the theme 'Walking the tightrope:
      trying to balance conflicting needs'. In the other narrative the theme 'Balancing
      closeness and distance' emerged. Eight sub-themes were identified illustrating
      the relocation time-line. CONCLUSION: Relocation from the care workers'
      perspective is a complex process with conflicting values and practical issues
      that hinder the provision of good care and security. IMPLICATIONS FOR PRACTICE:
      Supporting next of kin in the relocation decision-making process presupposes time
      for reflection in dialogue with staff. The risk of moral distress should be
      observed and support for care workers could be provided in the form of
      supervision, ethical consultations and local guidelines.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Horttana, Britt Marie
AU  - Horttana BM
AD  - School of Health and Medical Sciences, Orebro University and Lindesbergs
      Hospital, Orebro County Council, Orebro, Sweden. britt-marie.horttana@orebroll.se
FAU - Fahlstrom, Gunilla
AU  - Fahlstrom G
FAU - Ahlstrom, Gerd
AU  - Ahlstrom G
LA  - eng
PT  - Journal Article
DEP - 20100906
PL  - England
TA  - Int J Older People Nurs
JT  - International journal of older people nursing
JID - 101267281
SB  - IM
MH  - Affective Symptoms/psychology
MH  - Aged
MH  - Dementia/*nursing/*therapy
MH  - Female
MH  - *Geriatric Nursing
MH  - *Halfway Houses
MH  - Humans
MH  - Interprofessional Relations
MH  - Interviews as Topic
MH  - Male
MH  - Nursing Methodology Research
MH  - Nursing Staff/*psychology
MH  - *Patient Transfer
MH  - Qualitative Research
MH  - Residential Facilities
EDAT- 2011/05/05 06:00
MHDA- 2011/09/02 06:00
CRDT- 2011/05/05 06:00
PHST- 2011/05/05 06:00 [entrez]
PHST- 2011/05/05 06:00 [pubmed]
PHST- 2011/09/02 06:00 [medline]
AID - 10.1111/j.1748-3743.2010.00246.x [doi]
PST - ppublish
SO  - Int J Older People Nurs. 2011 Jun;6(2):93-101. doi:
      10.1111/j.1748-3743.2010.00246.x. Epub 2010 Sep 6.


PMID- 21538450
OWN - NLM
STAT- MEDLINE
DCOM- 20110823
LR  - 20211020
IS  - 1097-0258 (Electronic)
IS  - 0277-6715 (Linking)
VI  - 30
IP  - 11
DP  - 2011 May 20
TI  - Exploring the benefits of adaptive sequential designs in time-to-event endpoint
      settings.
PG  - 1199-217
LID - 10.1002/sim.4156 [doi]
AB  - Sequential analysis is frequently employed to address ethical and financial
      issues in clinical trials. Sequential analysis may be performed using standard
      group sequential designs, or, more recently, with adaptive designs that use
      estimates of treatment effect to modify the maximal statistical information to be
      collected. In the general setting in which statistical information and clinical
      trial costs are functions of the number of subjects used, it has yet to be
      established whether there is any major efficiency advantage to adaptive designs
      over traditional group sequential designs. In survival analysis, however,
      statistical information (and hence efficiency) is most closely related to the
      observed number of events, while trial costs still depend on the number of
      patients accrued. As the number of subjects may dominate the cost of a trial, an 
      adaptive design that specifies a reduced maximal possible sample size when an
      extreme treatment effect has been observed may allow early termination of accrual
      and therefore a more cost-efficient trial. We investigate and compare the
      tradeoffs between efficiency (as measured by average number of observed events
      required), power, and cost (a function of the number of subjects accrued and
      length of observation) for standard group sequential methods and an adaptive
      design that allows for early termination of accrual. We find that when certain
      trial design parameters are constrained, an adaptive approach to terminating
      subject accrual may improve upon the cost efficiency of a group sequential
      clinical trial investigating time-to-event endpoints. However, when the spectrum 
      of group sequential designs considered is broadened, the advantage of the
      adaptive designs is less clear.
CI  - Copyright (c) 2010 John Wiley & Sons, Ltd.
FAU - Emerson, Sarah C
AU  - Emerson SC
AD  - Department of Statistics, Oregon State University, Corvallis, OR 97331, USA.
FAU - Rudser, Kyle D
AU  - Rudser KD
FAU - Emerson, Scott S
AU  - Emerson SS
LA  - eng
GR  - T32 NS048005/NS/NINDS NIH HHS/United States
GR  - T32 NS048005-06/NS/NINDS NIH HHS/United States
GR  - T32NS048005/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20101229
PL  - England
TA  - Stat Med
JT  - Statistics in medicine
JID - 8215016
SB  - IM
MH  - Clinical Trials as Topic/*methods
MH  - Cost-Benefit Analysis/methods
MH  - Humans
MH  - *Models, Economic
MH  - *Models, Statistical
MH  - *Research Design
MH  - Sample Size
MH  - Survival Analysis
PMC - PMC3085096
MID - NIHMS255749
EDAT- 2011/05/04 06:00
MHDA- 2011/08/24 06:00
CRDT- 2011/05/04 06:00
PHST- 2008/12/27 00:00 [received]
PHST- 2010/10/27 00:00 [accepted]
PHST- 2011/05/04 06:00 [entrez]
PHST- 2011/05/04 06:00 [pubmed]
PHST- 2011/08/24 06:00 [medline]
AID - 10.1002/sim.4156 [doi]
PST - ppublish
SO  - Stat Med. 2011 May 20;30(11):1199-217. doi: 10.1002/sim.4156. Epub 2010 Dec 29.


PMID- 21532768
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1715-6580 (Electronic)
IS  - 1715-6572 (Linking)
VI  - 5
IP  - 4
DP  - 2010 May
TI  - Compulsory school-entry vaccination laws and exemptions: who is opting out in
      ontario and why does it matter?
PG  - 37-46
AB  - School-entry vaccination regulations are a policy instrument that has been widely
      used in some jurisdictions as a mechanism to ensure high immunization coverage
      rates. Exemptions to school-entry vaccination, which can be allowed on medical or
      non-medical grounds, present a number of ethical and policy challenges. In this
      paper, we consider the situation in Canada, where school-entry vaccination laws
      are rare. We present newly available aggregate-level registry data from Ontario
      comparing the use of medical and non-medical immunization exemptions to
      school-entry vaccination and the implications for population health.
FAU - Mah, Catherine L
AU  - Mah CL
AD  - Postdoctoral Fellow, School of Public Policy and Governance, University of
      Toronto Toronto, ON.
FAU - Guttmann, Astrid
AU  - Guttmann A
FAU - McGeer, Allison
AU  - McGeer A
FAU - Krahn, Murray
AU  - Krahn M
FAU - Deber, Raisa B
AU  - Deber RB
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Healthc Policy
JT  - Healthcare policy = Politiques de sante
JID - 101280107
PMC - PMC2875891
EDAT- 2011/05/03 06:00
MHDA- 2011/05/03 06:01
CRDT- 2011/05/03 06:00
PHST- 2011/05/03 06:00 [entrez]
PHST- 2011/05/03 06:00 [pubmed]
PHST- 2011/05/03 06:01 [medline]
PST - ppublish
SO  - Healthc Policy. 2010 May;5(4):37-46.


PMID- 21526670
OWN - NLM
STAT- MEDLINE
DCOM- 20110518
LR  - 20151119
IS  - 0544-0440 (Print)
IS  - 0544-0440 (Linking)
VI  - 20
IP  - 6
DP  - 2010 Oct
TI  - Effects of intraoperative-intrathecal sufentanil injection on postoperative pain 
      management after single level lumbar discectomy.
PG  - 839-44
AB  - BACKGROUND: For lumbar disc operation a chain of painful procedures including
      skin incision, muscle dissection and sometimes laminectomy should be performed.
      The combination of these manoeuvres results in significant post-operative pain.
      The standard way to reduce post-operative pain consist of intra-operative
      injection of local anaesthetic (Bupivicaine or Lidocaine) to the superficial
      tissues and intravenous, oral or rectal prescription of Opioid analgesics or
      other analgesics after operation, but inadequate analgesia, constipation and
      delayed mobilisation are frequent side effect of those treatments. The goal of
      this study was to reduce postoperative pain of patients which causes a reduction 
      in analgesic consumption and eventually shortened hospital stay and acceleration 
      in physical therapy programs and ambulation. MATERIALS AND METHODS: After ethical
      comitte approval, patients allocated in two groups A and B. Each group consisted 
      30 patients which all of them underwent general anesthesia. All of operations
      performed by same surgeon... After discectomy and at the end of surgery based on 
      patients odd or even number of hospital admission, one group (group-A) received
      sufentanil (Iranian pharmaceutic company) 0.05/kg intrathecaly injected in
      surgical level and the placebo group (group-B) normal saline was injected. In
      recovery room when patients were sufficiently awake for pain assessment, patients
      were asked to score pain on the verbal pain assessment score In both groups we
      compaired pain scores pre and postoperativly. The total dose of opioid
      requirement for patients and its time after operation was recorded. RESULTS: Of
      the 60 patients (ASA classes I and II) entering the study, no one excluded during
      our study. 30 patients received intrathecal injection of sufentanil as group-A or
      case and 30 patients normal saline as group-B or control. Mean age between two
      groups showed no significant difference. 45.7 year (SD = 11.5) for group-A and
      44.3 year (SD = 9.9) for group-B which did not differ between two groups (P =
      0.617). Urinary retension happened in 3 patients of group-A and 3 patients of
      group-B (P = 1). Pruritis happened in 1 patient of group-A and no patient in
      group-B (P = 0.15). Patients in group-A had reduced analgesic requirments (P =
      0.01). Preoperative low back pain based on NPS (numerical pain scores) criteria
      in group-A shows score 1, (n = 7) score 2, (n = 10) score 3, (n = 11) and score 4
      (n = 2) (mean = 2.2667 and SD = 0.9072). These scores in group-B showed score 2
      (n = 4) score 3 (n = 16) and score 4 (n = 10) (mean = 3.2 and SD = 0.6644) (P <
      0.001). After surgery low back pain assessment in two groups shows in group-A
      three patients had score 1, score 2, (n = 7) score 3, (n = 11) score 4, (n = 8)
      score 5 (n = 1) (mean = 2.9 and SD = 1.0289) and in group-B score 4 (n = 17)
      score 5 (n = 13) (mean = 4.4333 and SD = 0.5040) (P < 0.001). Preoperative lower 
      extremity radicular pain assessment in two groups shows a mean pain score of 8.3 
      with SD = 0.9523 in group-A and a mean of 8.3448 with SD = 1.1109 in group-B and 
      after operation a mean pain score of 1.7333 with SD = 0.8277 in group-A and a
      mean of 4.1667 with SD = 0.7466 in group-B. In walking ability assessments pre
      and postoperatively based on Mann-Whitney test it is shown that in group-A
      walking ability is better than group-B (P < 0.001). CONCLUSION: In this study we 
      studied the efficacy of intraoperative-intrathecal sufentanil injection versus
      placebo on post operative pain management. Our study showed that intrathecal (IT)
      sufentanil provided more effective analgesia postoperatively after single level
      discectomy. Urinary retention was equal in two groups. For more exact conclusions
      it is better to do a similar study on more patients.
FAU - Abrishamkar, Saeid
AU  - Abrishamkar S
AD  - Department of Neurosurgery, Isfahan University of Medical Sciences, Isfahan,
      Iran.
FAU - Karimi, Mohammadhossein
AU  - Karimi M
FAU - Safavi, Mohammadreza
AU  - Safavi M
FAU - Honarmand, Azim
AU  - Honarmand A
FAU - Safavi, Afshin
AU  - Safavi A
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Lebanon
TA  - Middle East J Anaesthesiol
JT  - Middle East journal of anaesthesiology
JID - 8604187
RN  - 0 (Analgesics, Opioid)
RN  - 451W47IQ8X (Sodium Chloride)
RN  - AFE2YW0IIZ (Sufentanil)
SB  - IM
MH  - Adult
MH  - Analgesics, Opioid/administration & dosage/*therapeutic use
MH  - Anesthesia, General
MH  - *Diskectomy
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Injections, Spinal
MH  - Intraoperative Care/*methods
MH  - Lumbar Vertebrae/*surgery
MH  - Male
MH  - Middle Aged
MH  - Pain Measurement
MH  - Pain, Postoperative/*drug therapy
MH  - Sodium Chloride/administration & dosage
MH  - Sufentanil/administration & dosage/*therapeutic use
EDAT- 2011/04/30 06:00
MHDA- 2011/05/19 06:00
CRDT- 2011/04/30 06:00
PHST- 2011/04/30 06:00 [entrez]
PHST- 2011/04/30 06:00 [pubmed]
PHST- 2011/05/19 06:00 [medline]
PST - ppublish
SO  - Middle East J Anaesthesiol. 2010 Oct;20(6):839-44.


PMID- 21526665
OWN - NLM
STAT- MEDLINE
DCOM- 20110518
LR  - 20141010
IS  - 0544-0440 (Print)
IS  - 0544-0440 (Linking)
VI  - 20
IP  - 6
DP  - 2010 Oct
TI  - Transient neurological symptoms following spinal anesthesia for cesarean section.
PG  - 809-13
AB  - BACKGROUND: Transient neurological symptoms (TNS) are defined as symmetrical
      bilateral pain in the back or buttocks or pain radiating to the lower extremities
      after recovery from spinal anesthesia. About 80-85% of cesarean sections are
      performed under spinal anesthesia in our centre. Our aim was to determine the
      incidence of TNS, risk factors and outcome of management in pregnant women
      undergoing cesarean section. PATIENTS AND METHODS: Approval was obtained from the
      hospital ethic's committee, and consent from the patients. ASA 1 and 2 pregnant
      women undergoing cesarean section under spinal anesthesia formed the subjects of 
      this prospective study. They were evaluated and pre-medicated by the attending
      anesthetists. Spinal anesthesia was performed at the L2-3 or L3-4 interspaces,
      using a 25G Quincke or 25G pencil point spinal needle with 0.5% heavy
      bupivacaine. The investigators interviewed the patients in the ward for three
      consecutive days, in order to identify those that developed TNS. RESULTS: One
      hundred and twenty consecutive patients were studied. TNS were documented in 12
      (10%) patients. Backache was recorded in 8 patients (6.6%), pain in the thighs in
      2 (1.7%) and pain in the buttocks in 2 (1.7%). Onset time of symptoms was
      recorded as 6-12 hrs in 5 (4.2%) patients, 12-24 hrs in 5 (4.2%) and 24-48 hrs in
      2 (1.6%). The patients that developed TNS were managed accordingly with
      satisfactory outcome. CONCLUSION: A follow-up for all patients that receive
      spinal anesthesia for cesarean section should constitute a standard practice.
FAU - Edomwonyi, N P
AU  - Edomwonyi NP
AD  - Obstetric Unit, Department of Anaesthesia, University of Benin Teaching Hospital,
      Benin City, Edo State, Nigeria.
FAU - Isesele, T O
AU  - Isesele TO
LA  - eng
PT  - Journal Article
PL  - Lebanon
TA  - Middle East J Anaesthesiol
JT  - Middle East journal of anaesthesiology
JID - 8604187
RN  - 0 (Anesthetics, Local)
RN  - Y8335394RO (Bupivacaine)
SB  - IM
MH  - Adult
MH  - Anesthesia, Spinal/*adverse effects
MH  - Anesthetics, Local/*adverse effects
MH  - Back Pain/chemically induced
MH  - Bupivacaine/*adverse effects
MH  - Buttocks
MH  - *Cesarean Section
MH  - Female
MH  - Humans
MH  - Leg
MH  - Pain/*chemically induced
MH  - Pregnancy
MH  - Prospective Studies
MH  - Risk Factors
MH  - Thigh
MH  - Time Factors
EDAT- 2011/04/30 06:00
MHDA- 2011/05/19 06:00
CRDT- 2011/04/30 06:00
PHST- 2011/04/30 06:00 [entrez]
PHST- 2011/04/30 06:00 [pubmed]
PHST- 2011/05/19 06:00 [medline]
PST - ppublish
SO  - Middle East J Anaesthesiol. 2010 Oct;20(6):809-13.


PMID- 21526309
OWN - NLM
STAT- MEDLINE
DCOM- 20111121
LR  - 20181201
IS  - 0717-6163 (Electronic)
IS  - 0034-9887 (Linking)
VI  - 138
IP  - 12
DP  - 2010 Dec
TI  - [Clinical ethics consultation in intensive care].
PG  - 1563
LID - /S0034-98872010001300017 [doi]
FAU - Vacarezza, Ricardo
AU  - Vacarezza R
LA  - spa
PT  - Letter
PT  - Comment
TT  - Consultoria etico clinica en cuidado intensivo.
DEP - 20110207
PL  - Chile
TA  - Rev Med Chil
JT  - Revista medica de Chile
JID - 0404312
SB  - IM
CON - Rev Med Chil. 2010 Jul;138(7):815-20. PMID: 21043075
MH  - Critical Care/*ethics
MH  - *Ethics Committees, Clinical
MH  - Ethics Consultation/*statistics & numerical data
MH  - Female
MH  - Humans
MH  - Male
EDAT- 2011/04/29 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/04/29 06:00
PHST- 2011/04/29 06:00 [entrez]
PHST- 2011/04/29 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0034-98872010001300017 [pii]
AID - /S0034-98872010001300017 [doi]
PST - ppublish
SO  - Rev Med Chil. 2010 Dec;138(12):1563. doi: /S0034-98872010001300017. Epub 2011 Feb
      7.


PMID- 21520559
OWN - NLM
STAT- MEDLINE
DCOM- 20110606
LR  - 20110426
IS  - 0214-1221 (Print)
IS  - 0214-1221 (Linking)
VI  - 23
IP  - 4
DP  - 2010 Oct
TI  - [Need of hepatic bipartition or split in the transplant in children].
PG  - 245-9
AB  - AIM: To analyze the benefits of Split (for adult and for child) in liver
      transplantation. PATIENT/METHODS: 1) Analysis of the waiting list mortality
      estimated on 228 inclusions for transplant since January 2004 to December 2008.2)
      Impact of the variant techniques (living-related donor and split) on the waiting 
      list mortality in our patients. 3) Analysis of the outcome of 33 split livers
      which allowed to perform 66 transplants (1994-2008). RESULTS: Estimated as number
      of patients by 1,000 candidates by year of exposure, the waiting list mortality
      was 110 in children older than 5 year old, 180 in children from 2 to 5 year-old, 
      90 in children between 1 and 2 year-old and 510 in younger than 1 year (p<0.05
      for the last group). 36/66 split grafts were implanted by our group. Five grafts 
      were lost, 3 due to retransplantation and 2 due to death. Overall patient/graft
      survival alter 10 years of follow-up was 94.5% and 85.1%, respectively. The rest 
      of the grafts (n=30), were used in other hospitals, and 4 were lost in the early 
      postoperative period. Since the beginning of the study, 85.4% of children between
      1 and 2 years, received a living-donor or a split graft, as only 59.9% in the
      younger than 1 year-old group. CONCLUSION: Our results absolutely justify the
      ethics of split liver transplantation for an adult and a child. Despite other
      factors, the benefits of the variant techniques in the 1-2 year-old group are
      obvious. Up to 60% optimization with these techniques in children younger than 1 
      year would not be yet enough in order to decrease the mortality waiting list down
      to that of the rest of the groups.
FAU - Andres, A M
AU  - Andres AM
AD  - Departamento de Cirugia Pediatrica, Unidad de Trasplante Infantil, Hospital
      Universitario La Paz, Madrid. aneandresmo@hotmail.com
FAU - Lopez Santamaria, M
AU  - Lopez Santamaria M
FAU - Burgos, L
AU  - Burgos L
FAU - Hernandez, F
AU  - Hernandez F
FAU - Encinas, J L
AU  - Encinas JL
FAU - Barrena, S
AU  - Barrena S
FAU - Miguel, M
AU  - Miguel M
FAU - Leal, N
AU  - Leal N
FAU - Martinez, L
AU  - Martinez L
FAU - Gamez, M
AU  - Gamez M
FAU - Murcia, J
AU  - Murcia J
FAU - Frauca, E
AU  - Frauca E
FAU - Jara, P
AU  - Jara P
FAU - Tovar, J A
AU  - Tovar JA
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Multicenter Study
TT  - Necesidad de la biparticion hepatica o split en el trasplante en ninos.
PL  - Spain
TA  - Cir Pediatr
JT  - Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica
JID - 8900492
SB  - IM
MH  - Adult
MH  - Child, Preschool
MH  - Hepatectomy/*methods
MH  - Humans
MH  - Infant
MH  - *Liver Transplantation
MH  - Retrospective Studies
MH  - Tissue and Organ Procurement/*methods
EDAT- 2011/04/28 06:00
MHDA- 2011/06/07 06:00
CRDT- 2011/04/28 06:00
PHST- 2011/04/28 06:00 [entrez]
PHST- 2011/04/28 06:00 [pubmed]
PHST- 2011/06/07 06:00 [medline]
PST - ppublish
SO  - Cir Pediatr. 2010 Oct;23(4):245-9.


PMID- 21516924
OWN - NLM
STAT- MEDLINE
DCOM- 20110525
LR  - 20211203
IS  - 0885-6028 (Print)
IS  - 0885-6028 (Linking)
VI  - 21
IP  - 2
DP  - 2010 Dec
TI  - Reducing the rate of cervical cancer: ethical challenges in public health.
PG  - 39-43
AB  - Human papilloma virus (HPV) is the most common sexually transmitted infection in 
      the United States and HPV is the single most significant risk factor for
      acquiring cervical cancer. There are two vaccines that prevent some strains of
      HPV and are believed to help reduce the rate of cervical cancer: Whether or not
      the HPV vaccine should be mandated has resulted in monumental debates and given
      rise to several ethical concerns. For instance, how will mandating this vaccine
      affect the patient's right to self determination ? Will parents accept a vaccine 
      that prevents a disease that is primarily sexually transmitted and targeted for
      adolescents girls? Have studies proven the vaccine to be effective against the
      types of HPV associated with cervical cancer? This paper critically analyzes
      several studies that address these questions and utilizes the nursing code of
      ethics as a framework to reveal inherent ethical issues confronting nurses.
FAU - Beard, Kenya
AU  - Beard K
AD  - Hunter-Bellevue School of Nursing, New York, NY 10010, USA.
      kbeard@hunter.cuny.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Natl Black Nurses Assoc
JT  - Journal of National Black Nurses' Association : JNBNA
JID - 8703519
RN  - 0 (Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18)
RN  - 0 (Papillomavirus Vaccines)
MH  - Blacks
MH  - *Ethics
MH  - Female
MH  - Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18
MH  - Humans
MH  - Papillomavirus Vaccines/*administration & dosage
MH  - *Public Health
MH  - Uterine Cervical Neoplasms/ethnology/*prevention & control
EDAT- 2011/04/27 06:00
MHDA- 2011/05/26 06:00
CRDT- 2011/04/27 06:00
PHST- 2011/04/27 06:00 [entrez]
PHST- 2011/04/27 06:00 [pubmed]
PHST- 2011/05/26 06:00 [medline]
PST - ppublish
SO  - J Natl Black Nurses Assoc. 2010 Dec;21(2):39-43.


PMID- 21513145
OWN - NLM
STAT- MEDLINE
DCOM- 20110520
LR  - 20161020
IS  - 0253-9772 (Print)
IS  - 0253-9772 (Linking)
VI  - 32
IP  - 12
DP  - 2010 Dec
TI  - [Current progress and application prospects of induced pluripotent stem cells].
PG  - 1205-14
AB  - Induced pluripotent stem (iPS) cells can be directly generated from somatic cells
      by transduction of a few defined transcription factors. This technique avoids
      immunological rejection and ethical difficulties, which is a great revolution in 
      life sciences. Like embryonic stem (ES) cells, iPS cells have the ability to
      self-renew through mitotic cell division and thus remain in its undifferentiated 
      state and the ability to differentiate into not only all derivatives of the three
      primary germ layers: ectoderm, endoderm, and mesoderm, but also many mature cells
      in vitro. Therefore, iPS cells are important for theoretic study and therapeutic 
      application. Here, we discuss recent advances in generating induced pluripotent
      stem cells, different reprogramming methods, and clinical applications of iPS
      cells. Finally, current problems of iPS cells and its prospects in transgenic
      animals are also discussed. This article is a summary of current research
      advances in reprogramming cells into induced pluripotent stem cells.
FAU - Qin, Tong
AU  - Qin T
AD  - Institute of Animal Scineces, Chinese Academy of Aricultural Sciences, Beijing
      100193, China. qintong1980@yahoo.com.cn
FAU - Miao, Xiang-Yang
AU  - Miao XY
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - China
TA  - Yi Chuan
JT  - Yi chuan = Hereditas
JID - 9436478
SB  - IM
MH  - Animals
MH  - Cellular Reprogramming
MH  - Genetic Engineering/adverse effects/*methods
MH  - Humans
MH  - *Induced Pluripotent Stem Cells/cytology/metabolism
MH  - Safety
MH  - Transduction, Genetic
EDAT- 2011/04/26 06:00
MHDA- 2011/05/21 06:00
CRDT- 2011/04/26 06:00
PHST- 2011/04/26 06:00 [entrez]
PHST- 2011/04/26 06:00 [pubmed]
PHST- 2011/05/21 06:00 [medline]
PST - ppublish
SO  - Yi Chuan. 2010 Dec;32(12):1205-14.


PMID- 21513138
OWN - NLM
STAT- MEDLINE
DCOM- 20110531
LR  - 20110422
IS  - 0001-4079 (Print)
IS  - 0001-4079 (Linking)
VI  - 194
IP  - 6
DP  - 2010 Jun
TI  - [First-aid in France. Current situation and future perspectives].
PG  - 1071-93
AB  - First-aid--treatment aimed at enabling a victim to survive pending the arrival of
      qualified medical support--is less well developed in France than in many other
      industrialized countries, especially among the general public. The current status
      of first-aid in France is paradoxical: schooling is free and obligatory, the
      ambulance service and emergency services are of the highest quality, but the
      general public are too often passive and unknowledgeable when faced with an
      emergency situation. This situation is due to several factors, including the
      complexity of first-aid training and regulations, the involvement of too many
      public bodies, the legal liability of the first-aider, and a lack of ongoing
      training. The French National Academy of Medicine recommends 8 measures to
      improve this situation: Provide a legal definition of first-aid: "a set of
      recognized measures aimed, in an emergency setting, at preserving the physical
      and psychological integrity of the victim of an accident or illness, notably
      pending the arrival of professional medical assistance". Waive, as in many other 
      countries, civil and legal responsibility for the non professional first-aider,
      except in case of clear negligence. Reinforce the organization of first-aid in
      France in order to monitor the number and quality of first-aiders, and to ensure 
      theoretical and pedagogic research; create a communications department capable of
      supporting and promoting first-aid. Improve access to first-aid training by
      increasing the number of situations in which it is obligatory (driving tuition,
      school and university examinations, group responsibility, at-risk practices), by 
      providing financial assistance for certain groups, and by ensuring routine
      training at school, in the armed forces, and in the workplace. Create a
      progressive and integrated citizen first-aid training course with individual
      modules, ensuring that first-aiders update and perfect their knowledge throughout
      life. Soften pedagogic rules and shorten the training period in order to make
      volunteer first- aiding more accessible, notably by employing the latest teaching
      methods. Authorize professional first-aiders to use monitoring equipment, airway 
      clearance techniques, and certain emergency medications. Finally, give first-aid 
      a European dimension, underline the need for prevention, and reinforce and
      develop the ethical side of first-aiding. First-aid provides access to
      citizenship and altruism, is the first link in the chain of emergency medical
      assistance capable of saving lives, and is crucial for civil security As such, it
      is a national cause and must be strongly supported by the political and
      administrative authorities.
FAU - Larcan, Alain
AU  - Larcan A
AD  - L'Academie nationale de medecine.
FAU - Julien, Henri
AU  - Julien H
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Le Secourisme en France. Panorama et perspectives.
PL  - Netherlands
TA  - Bull Acad Natl Med
JT  - Bulletin de l'Academie nationale de medecine
JID - 7503383
SB  - IM
MH  - *First Aid
MH  - France
MH  - Health Education/*organization & administration
MH  - Humans
EDAT- 2011/04/26 06:00
MHDA- 2011/06/01 06:00
CRDT- 2011/04/26 06:00
PHST- 2011/04/26 06:00 [entrez]
PHST- 2011/04/26 06:00 [pubmed]
PHST- 2011/06/01 06:00 [medline]
PST - ppublish
SO  - Bull Acad Natl Med. 2010 Jun;194(6):1071-93.


PMID- 21513126
OWN - NLM
STAT- MEDLINE
DCOM- 20110531
LR  - 20110422
IS  - 0001-4079 (Print)
IS  - 0001-4079 (Linking)
VI  - 194
IP  - 6
DP  - 2010 Jun
TI  - [Perinatal asphyxia and cerebral palsy: medicolegal implications].
PG  - 891-901; discussion 901
AB  - Over the last 30 years, improvements in obstetric practice (systematic fetal
      perpartum monitoring, Caesarean section, etc.) have markedly reduced the
      incidence of perinatal asphyxia, especially in the perpartum period. Yet the
      incidence of cerebral palsy has remained stable, at around 2 per 1000 live
      births, owing to the fact that this disorder is generally due to antenatal
      factors. Population-based studies have further demonstrated that acute perpartum 
      asphyxia is a rare cause of cerebral palsy. Obstetrics is a discipline
      particularly subject to insurance claims, often because of late use or non use of
      Cesarean section. Perinatal judicial expertise is too often based on obsolete
      notions. Reform is necessary, focusing on upstream structural problems. The
      American model initiated by neurologists and adopted by many other disciplines
      should be widely adopted, including by lawyers and magistrates. It involves
      verifying the ethical character of the expertise challenged by the injured party,
      and drawing conclusions for professional practice?
FAU - Racinet, Claude
AU  - Racinet C
AD  - Handicap de l'Enfant, 23 Boulevard Albert 1er de Belgique, 38000 Grenoble.
      claude.racinet@orange.fr
FAU - Hoffmann, Pascale
AU  - Hoffmann P
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Asphyxie perinatale et paralysie cerebrale: implications medico-legales.
PL  - Netherlands
TA  - Bull Acad Natl Med
JT  - Bulletin de l'Academie nationale de medecine
JID - 7503383
SB  - IM
MH  - Asphyxia Neonatorum/*complications
MH  - Cerebral Palsy/*etiology
MH  - Female
MH  - Fetal Hypoxia/*complications
MH  - Humans
MH  - Infant, Newborn
MH  - Liability, Legal
MH  - Obstetrics/legislation & jurisprudence
MH  - Pregnancy
EDAT- 2011/04/26 06:00
MHDA- 2011/06/01 06:00
CRDT- 2011/04/26 06:00
PHST- 2011/04/26 06:00 [entrez]
PHST- 2011/04/26 06:00 [pubmed]
PHST- 2011/06/01 06:00 [medline]
PST - ppublish
SO  - Bull Acad Natl Med. 2010 Jun;194(6):891-901; discussion 901.


PMID- 21510334
OWN - NLM
STAT- MEDLINE
DCOM- 20110729
LR  - 20161021
IS  - 1134-7198 (Print)
IS  - 1134-7198 (Linking)
IP  - 33
DP  - 2010 Jul-Dec
TI  - [Legal regulation of cloning in the United States].
PG  - 93-125
AB  - In a controversial matter such as cloning the study of the treatment that it
      raises in the first technological, political and cultural power is essential. Its
      role, in many ways, on the leading of the Humanity progress deserves a detailed
      attention. Moral pluralism in a country where various ethical-religious
      traditions converge and coexist, the kaleidoscopic legal structure of a Federal
      State, the strength of its biotechnology industry, the passion for research that 
      crosses the nation and the frontier spirit in facing new challenges become the
      first power pioneer in many social phenomena and a mirror to look at other
      countries in an attempt to emulate its achievements (or to follow in its
      mistakes). The debate on the constitutionality of cloning hinges on the ability
      of public authorities to interfere in personal decisions and on the existence of 
      more valuable public interest that justify such intervention. This article also
      discusses the criteria for awarding the regulation of cloning to the federation
      or to the states.
FAU - Puertas Tarjuelo, Angel Luis
AU  - Puertas Tarjuelo AL
AD  - Universidad Autonoma de Barcelona, Barcelona, Espana.
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Regulacion juridica de la clonacion en los Estados Unidos.
PL  - Spain
TA  - Rev Derecho Genoma Hum
JT  - Revista de derecho y genoma humano = Law and the human genome review
JID - 101558644
SB  - IM
MH  - Cloning, Organism/*legislation & jurisprudence
MH  - Constitution and Bylaws
MH  - Government
MH  - United States
EDAT- 2011/04/23 06:00
MHDA- 2011/07/30 06:00
CRDT- 2011/04/23 06:00
PHST- 2011/04/23 06:00 [entrez]
PHST- 2011/04/23 06:00 [pubmed]
PHST- 2011/07/30 06:00 [medline]
PST - ppublish
SO  - Rev Derecho Genoma Hum. 2010 Jul-Dec;(33):93-125.


PMID- 21510133
OWN - NLM
STAT- MEDLINE
DCOM- 20110729
LR  - 20161021
IS  - 1134-7198 (Print)
IS  - 1134-7198 (Linking)
IP  - 33
DP  - 2010 Jul-Dec
TI  - The right to secure food in the perspective of the general improvement of the
      fundamental rights.
PG  - 13-9
AB  - The 9th International Congress of the European Society EurSafe (European Society 
      of Agricultural and Food Ethics) was held on September 15-18, 2010, in Bilbao,
      Spain, gathering 150 experts from more than 20 countries, with the purpose of
      reflecting on ethical-social and legal issues posed by bio-scientific advances
      and the challenges of agriculture and food in the Third Millennium. Under the
      motto "Global Food Security: Ethical and Legal Challenges", the Congress was
      organized by the Inter-University Chair in Law and the Human Genome and
      particular attention was paid to the need to improve access to sufficient,
      nutritionally adequate and safe food for all humankind, and to the socio-economic
      and political obstacles which, from day to day, impede this access, given that
      twenty years after taking on the Millennium Objectives, poverty and hunger have
      not only failed to decline, but continue to reach record figures. Professor
      Stefano Rodota, member of the European Group on Ethics in Science and New
      Technologies, deserves a special mention. That Group, independent and
      multidisciplinary, was created for the purpose of advising the European
      Commission on ethical aspects of science and new technologies in connection with 
      the preparation and implementation of Community legislation and policy. Below we 
      reproduce the speech given by Professor Stefano Rodota during the EurSafe 2010
      Congress's Plenary Session hold in Bilbao, 17th September 2010.
FAU - Rodota, Stefano
AU  - Rodota S
AD  - University of Rome La Sapienza, Rome, Italy.
LA  - eng
PT  - Journal Article
PL  - Spain
TA  - Rev Derecho Genoma Hum
JT  - Revista de derecho y genoma humano = Law and the human genome review
JID - 101558644
SB  - IM
MH  - *Food Supply
MH  - *Human Rights
MH  - Humans
EDAT- 2011/04/23 06:00
MHDA- 2011/07/30 06:00
CRDT- 2011/04/23 06:00
PHST- 2011/04/23 06:00 [entrez]
PHST- 2011/04/23 06:00 [pubmed]
PHST- 2011/07/30 06:00 [medline]
PST - ppublish
SO  - Rev Derecho Genoma Hum. 2010 Jul-Dec;(33):13-9.


PMID- 21502008
OWN - NLM
STAT- MEDLINE
DCOM- 20160422
LR  - 20181201
IS  - 1948-2124 (Electronic)
IS  - 1079-7440 (Linking)
VI  - 64
IP  - 2
DP  - 2010 Mar-Apr
TI  - Reducing hospital-acquired infection by quantitative risk modeling of intravenous
      bag preparation.
PG  - 82-91
AB  - Vascular access of patients by peripheral and central venous catheters for the
      delivery of sterile or aseptically manufactured parenterals is commonly regarded 
      as one of the major causes of blood stream infections. Rigorous evaluation and
      management of the risks of microbial infection originating from the
      administration of aseptically manufactured therapies remain imperative to reduce 
      patient infection risks. Healthcare clinicians are continually faced with
      choosing intravenous (IV) parenteral administration strategies to minimize
      patient blood stream infection risk. Data facilitating such decisions are often
      difficult to obtain. Analysis and interpretation of the available, reported
      hospital infection rate data to evaluate medical device- and therapy-associated
      infection rates are constrained by the variability and uncertainty associated
      with each individual administration scenario. Moreover, clinical trials
      quantifying infection risk are constrained by their practicality, cost, and the
      control of the exacting requisite trial criteria. Furthermore, it is ethically
      inappropriate to systematically conduct clinical evaluations incorporating
      conditions that do not favor the best possible patient outcomes. Quantitative
      risk modeling (QRM) is a unique tool offering an alternative and affective means 
      of assessing design and clinical use in the context of the clinical environment
      on medical device and combinatorial therapy infection rates. Here, we report the 
      generation of QRMs and the evaluation of manual admixing IV bags for use in IV
      administration sets upon patient infection rates. The manual admixing of IV bags 
      was assessed for the opportunity and risk of microbial ingress accessing across
      the sterile barrier during clinical preparation and contaminating the IV
      solution. The risk of microbial contamination was evaluated under (a) ISO 5
      compounding conditions adopting ideal aseptic technique (in compliance with USP
      <797>) and (b) realistic worst-case point-of-care conditions (typically found in 
      hospital wards). These choices of conditions encompass the complete spectrum of
      clinical environments encountered in the hospital. The evaluation estimated
      contamination rates ranged from <2.2 ppm (2.2 contaminated units in every million
      uses) to 2.9% (29 contaminated units in every 1000 uses), contingent upon the
      clinical environment. QRM permits the swift probabilistic evaluation of
      contamination rates providing the healthcare professional with data to make an
      informed choice of medical devices and a preparation strategy in their precise
      clinical context, reducing hospital acquired infections for optimal clinical
      patient outcomes.
FAU - Tidswell, Edward C
AU  - Tidswell EC
AD  - Director,Research, Baxter Healthcare Corporation, Round Lake, IL 60073.
FAU - Rockwell, Jim
AU  - Rockwell J
FAU - Wright, Marc-Oliver
AU  - Wright MO
LA  - eng
PT  - Journal Article
PL  - United States
TA  - PDA J Pharm Sci Technol
JT  - PDA journal of pharmaceutical science and technology
JID - 9439538
SB  - IM
MH  - Central Venous Catheters
MH  - *Cross Infection
MH  - Humans
MH  - Infection Control
MH  - *Infusions, Intravenous
MH  - Injections, Intravenous
MH  - Parenteral Nutrition/instrumentation
MH  - Point-of-Care Systems
MH  - Risk
EDAT- 2011/04/20 06:00
MHDA- 2016/04/23 06:00
CRDT- 2011/04/20 06:00
PHST- 2011/04/20 06:00 [entrez]
PHST- 2011/04/20 06:00 [pubmed]
PHST- 2016/04/23 06:00 [medline]
AID - 64/2/82 [pii]
PST - ppublish
SO  - PDA J Pharm Sci Technol. 2010 Mar-Apr;64(2):82-91.


PMID- 21500510
OWN - NLM
STAT- MEDLINE
DCOM- 20110616
LR  - 20191112
IS  - 0102-6933 (Print)
IS  - 0102-6933 (Linking)
VI  - 31
IP  - 2
DP  - 2010 Jun
TI  - [Child hospitalization: how the nursing staff conceives the accompanying mother].
PG  - 300-6
AB  - The presence of the family is fundamental in the care of hospitalized child,
      because, as a source of protection and security, it provides an environment less 
      aggressive. The objective of this study was to understand how nursing staff
      conceives the accompanying mother This is an exploratory qualitative research,
      developed in a reference hospital of infant care in the Northeast of Brazil,
      carried out between April and May, 2007, through semi-structured interview. Data 
      were subjected to thematic analysis and the ethical aspects respected. We
      observed that although the mother is recognized as an important person in the
      process of giving support to the child, she does not receive proper care from
      health professionals. Seen as agents in the process work, mothers do not
      participate in decision making yet they carry the responsibility of nursing care.
      So it is important that members of the nursing staff reorient their work with the
      objective of building links and a comprehensive care.
FAU - Quirino, Daniela Dias
AU  - Quirino DD
AD  - Programa de Pos-Graduacao em Enfermagem da Universidade Federal da Paraiba
      (PPGEnf/UFPB), Joao Pessoa, Paraiba, Brasil. danydiasq@hotmail.com
FAU - Collet, Neusa
AU  - Collet N
FAU - Neves, Ana Flavia Gomes Britto
AU  - Neves AF
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Hospitalizacao infantil: concepcoes da enfermagem acerca da mae acompanhante.
PL  - Brazil
TA  - Rev Gaucha Enferm
JT  - Revista gaucha de enfermagem
JID - 8504882
MH  - *Attitude of Health Personnel
MH  - Child
MH  - *Child, Hospitalized
MH  - *Hospitalization
MH  - Humans
MH  - *Mothers
MH  - *Nursing Staff, Hospital
EDAT- 2011/04/20 06:00
MHDA- 2011/06/17 06:00
CRDT- 2011/04/20 06:00
PHST- 2011/04/20 06:00 [entrez]
PHST- 2011/04/20 06:00 [pubmed]
PHST- 2011/06/17 06:00 [medline]
AID - 10.1590/s1983-14472010000200014 [doi]
PST - ppublish
SO  - Rev Gaucha Enferm. 2010 Jun;31(2):300-6. doi: 10.1590/s1983-14472010000200014.


PMID- 21500481
OWN - NLM
STAT- MEDLINE
DCOM- 20110708
LR  - 20141120
IS  - 0048-7848 (Print)
IS  - 0048-7848 (Linking)
VI  - 114
IP  - 4
DP  - 2010 Oct-Dec
TI  - [SEM comparative analysis of the composite diacrylic resin-enamel interface in
      laser and bur prepared cavities].
PG  - 1204-8
AB  - UNLABELLED: The aim of this study was to demonstrate that the size of the hybrid 
      layer (HL) in the prepared enamel mechanic (M) and kinetic (K) with laser
      (WaterlaseMDBiolase), evaluated by scanning electron microscopy (SEM) restored
      with two types of resin composite is different. MATERIAL AND METHOD: The study
      was realized in vitro on a sample of 40 extracted human premolar and molars teeth
      for orthodontic or periodontal reasons. The teeth were divided at random into
      equal four groups (Gr). There has been Class I cavities with a depth of 2 mm (M) 
      at high and low speed with cylindrical diamond No.1 and globular carbide and (K) 
      peaks MZ6-5, 5W+20 Hz 30% water 60% air. The teeth were restored using 3M
      Schotchbond Etch, 3M Single Bond Dental Adhesive System: Gr. 1: (K)(n = 10)-3M
      Filtekflow; Gr.2 : (K)(n = 10)3M FiltekZ250; Gr.3: (M)(n = 10)3M Filtekflow;
      Gr.4: (M)(n = 10)3M FiltekZ250. The materials were placed in a single layer and
      photoactivate source LED SmartLite (Dentsply), termocycling 500 cycles (5
      degrees-55 degrees), stored (48h), cut lengthwise (diamond), polished,
      conditioned (H3PO4-37% -5s) analyzed by SEM (JEOLJSM 6390), SPSS 13.00
      statistically analyzed (ANOVA, p = 0.05). RESULTS: Analysis of the (HL) has
      highlighted differences between groups p = 0.05 average size (HL) being
      Gr.1;20.80 (+/- 0.72)microm, Gr.2;4.034 (+/- 0.0076)microm, Gr.3, 14.13 (+/-
      0.63)microm, Gr.4, 1,43 (+/- 0.16)microm. Value size (HL) was influenced by the
      cavity preparation method for samples prepared by laser p = 0,005 in terms of
      size and in advantage of mechanical preparations in terms of quality (HL). Also
      the value of (HL) size was influenced by the type of material used in advance
      Gr.2 p = 0.0017. CONCLUSIONS: The sealing of cavity depends more on the creep of 
      materials and less on the type of preparation. Permission was obtained from a
      institutional ethical committee of "Gr.T. Popa" University of Medicine and
      Pharmacy Iasi and that subjects gave written, informed consent).
FAU - Bamboi, Irina
AU  - Bamboi I
AD  - Universitatii de Medicina si Farmacie Gr.T. Popa Iasi.
FAU - Saveanu, Catalina Iulia
AU  - Saveanu CI
FAU - Danila, I
AU  - Danila I
FAU - Chiriac, H
AU  - Chiriac H
FAU - Gherasim, Carmen
AU  - Gherasim C
LA  - rum
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
TT  - Studiu de analiza comparativa SEM a interfetei rasina diacrilica compozita-smalt 
      in cavitati preparate mecanic si kinetic cu laser.
PL  - Romania
TA  - Rev Med Chir Soc Med Nat Iasi
JT  - Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi
JID - 0413735
RN  - 0 (3M Single Bond Dental Adhesive)
RN  - 0 (Composite Resins)
RN  - 0 (Dentin-Bonding Agents)
RN  - 0 (Methacrylates)
RN  - 24448-20-2 (2,2-bis-(4-(2-methacryloxyethoxy)phenyl)propane)
SB  - IM
MH  - Algorithms
MH  - Analysis of Variance
MH  - Bicuspid
MH  - *Composite Resins/chemistry
MH  - Dental Caries/*therapy
MH  - Dental Cavity Lining/methods
MH  - *Dental Cavity Preparation/methods
MH  - *Dental Enamel
MH  - *Dental High-Speed Technique
MH  - Dental Marginal Adaptation
MH  - Dentin-Bonding Agents
MH  - Humans
MH  - In Vitro Techniques
MH  - *Lasers
MH  - *Methacrylates
MH  - *Microscopy, Electron, Scanning/methods
MH  - Molar
EDAT- 2011/04/20 06:00
MHDA- 2011/07/09 06:00
CRDT- 2011/04/20 06:00
PHST- 2011/04/20 06:00 [entrez]
PHST- 2011/04/20 06:00 [pubmed]
PHST- 2011/07/09 06:00 [medline]
PST - ppublish
SO  - Rev Med Chir Soc Med Nat Iasi. 2010 Oct-Dec;114(4):1204-8.


PMID- 21495246
OWN - NLM
STAT- MEDLINE
DCOM- 20110817
LR  - 20110414
IS  - 1132-1989 (Print)
IS  - 1132-1989 (Linking)
VI  - 21
IP  - 73
DP  - 2010 Sep-Dec
TI  - [Report of the National Association of Bioethics and Medical Ethics on the
      Declaration of the Ethics Commission of the SEGO on the Organic Law 2/2010 on
      sexual and reproductive health and the voluntary interruption of pregnancy].
PG  - 423-6
LA  - spa
PT  - News
TT  - Informe de la Asociacion Nacional de Bioetica y Etica Medica (AEBI) acerca de la 
      Declaracion de la Comision de Bioetica de la SEGO sobre la Ley Organica 2/2010 de
      salud sexual y reproductiva y de la interrupcion voluntaria del embarazo.
PL  - Spain
TA  - Cuad Bioet
JT  - Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y
      Etica Medica
JID - 101312976
SB  - IM
MH  - Abortion, Induced/*legislation & jurisprudence
MH  - *Bioethical Issues
MH  - *Ethics, Medical
MH  - Female
MH  - Humans
MH  - Pregnancy
MH  - Reproductive Medicine/*legislation & jurisprudence
MH  - Sexuality
MH  - *Societies, Medical
MH  - Spain
EDAT- 2011/04/19 06:00
MHDA- 2011/08/19 06:00
CRDT- 2011/04/16 06:00
PHST- 2011/04/16 06:00 [entrez]
PHST- 2011/04/19 06:00 [pubmed]
PHST- 2011/08/19 06:00 [medline]
PST - ppublish
SO  - Cuad Bioet. 2010 Sep-Dec;21(73):423-6.


PMID- 21495245
OWN - NLM
STAT- MEDLINE
DCOM- 20110817
LR  - 20110414
IS  - 1132-1989 (Print)
IS  - 1132-1989 (Linking)
VI  - 21
IP  - 73
DP  - 2010 Sep-Dec
TI  - [Request of the Spanish Society of bioethics and medical ethics addressed to the 
      General Council of Official Colleges of Physicians and the Central Commission on 
      Deontology and Medical Law, on the conscientious objection regarding several
      aspects of the Organic Law 2/2010 on sexual and reproductive health and the
      voluntary interruption of pregnancy].
PG  - 419-22
LA  - spa
PT  - News
TT  - Solicitud de la Asociacion Espanola de Bioetica y Etica Medica (AEBI), dirigida
      al Consejo General de Colegios Oficiales de Medicos y Comision Central de
      Deontologia y Derecho Medico, acerca de la objecion de conciencia ante algunos
      aspectos de la Ley Organica 2/2010 de salud sexual y reproductiva y de la
      interrupcion voluntaria del embarazo.
PL  - Spain
TA  - Cuad Bioet
JT  - Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y
      Etica Medica
JID - 101312976
SB  - IM
MH  - Abortion, Induced/*legislation & jurisprudence
MH  - *Attitude of Health Personnel
MH  - *Bioethical Issues
MH  - *Ethics, Medical
MH  - Female
MH  - Humans
MH  - Pregnancy
MH  - *Professional Autonomy
MH  - Reproductive Medicine/*legislation & jurisprudence
MH  - Sexuality
MH  - *Societies, Medical
MH  - Spain
EDAT- 2011/04/19 06:00
MHDA- 2011/08/19 06:00
CRDT- 2011/04/16 06:00
PHST- 2011/04/16 06:00 [entrez]
PHST- 2011/04/19 06:00 [pubmed]
PHST- 2011/08/19 06:00 [medline]
PST - ppublish
SO  - Cuad Bioet. 2010 Sep-Dec;21(73):419-22.


PMID- 21492286
OWN - NLM
STAT- MEDLINE
DCOM- 20110729
LR  - 20110415
IS  - 1365-2702 (Electronic)
IS  - 0962-1067 (Linking)
VI  - 20
IP  - 9-10
DP  - 2011 May
TI  - Parental liminality: a way of understanding the early experiences of parents who 
      have a very preterm infant.
PG  - 1462-71
LID - 10.1111/j.1365-2702.2010.03311.x [doi]
AB  - AIM: The aim of this study was to explore the early experiences of parents who
      have a very preterm infant. BACKGROUND: Very preterm infants are physiologically 
      ill-prepared for extra-uterine life, but a greater number now survive birth and
      the postnatal period. The complex needs of the very preterm infant are met in the
      technological environment of the neonatal intensive care area, separating
      parents, physically and psychologically from their very preterm infant. Studies
      exploring the parental experience have identified parental stress; lowly parental
      status and attachment issues as areas of concern. However, there is little
      understanding about the early parental experience. DESIGN: This study used a
      phenomenological interpretive design. METHODS: Ethical approval to conduct this
      study using two study centres was obtained. An interpretive interactionist
      approach guided this study. Data were collected from three sources: 20 parents of
      very preterm infants, five senior neonatal nurses and seven neonatal intensive
      care nurses. Purposive sampling was used for the first and second sources, and
      data were collected through semi-structured interviews. The third source of data 
      occurred opportunistically through one focus group. ANALYSIS: Analysis involved
      constant comparative analysis. RESULTS: Crisis, uncertainty and powerlessness,
      properties of liminality framed this early complex parental transition. It is
      argued that the overarching theme of parental liminality best framed the parental
      physical, psychological and social experiences. CONCLUSION: This qualitative
      interpretive study identified that parents of very preterm infants experienced
      many crises, uncertainty and powerlessness in their transition to parenthood,
      making them liminal people. RELEVANCE TO CLINICAL PRACTICE: Parental liminality
      provides a means of conceptualising the early experiences of parents of very
      preterm infants, providing practitioners, at strategic and operational levels,
      with the means of developing supporting interventions in the early stages of
      transition for parents of very preterm infants. Such support could mediate
      parent-infant relationships.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Watson, Gill
AU  - Watson G
AD  - School of Nursing and Midwifery, University of Dundee, Dundee, Scotland.
      g.watson@dundee.ac.uk
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20100923
PL  - England
TA  - J Clin Nurs
JT  - Journal of clinical nursing
JID - 9207302
MH  - Adult
MH  - Humans
MH  - Infant, Newborn
MH  - *Infant, Premature
MH  - Neonatal Nursing
MH  - Parents/*psychology
EDAT- 2011/04/16 06:00
MHDA- 2011/07/30 06:00
CRDT- 2011/04/16 06:00
PHST- 2011/04/16 06:00 [entrez]
PHST- 2011/04/16 06:00 [pubmed]
PHST- 2011/07/30 06:00 [medline]
AID - 10.1111/j.1365-2702.2010.03311.x [doi]
PST - ppublish
SO  - J Clin Nurs. 2011 May;20(9-10):1462-71. doi: 10.1111/j.1365-2702.2010.03311.x.
      Epub 2010 Sep 23.


PMID- 21491743
OWN - NLM
STAT- MEDLINE
DCOM- 20110525
LR  - 20110414
IS  - 0995-3914 (Print)
IS  - 0995-3914 (Linking)
VI  - 22
IP  - 6
DP  - 2010 Nov-Dec
TI  - [Health system reforms, economic constraints and ethical and legal values].
PG  - 625-36
AB  - Health system and hospital reforms have led to important and on-going
      legislative, structural and organizational changes. Is there any logic at work
      within the health system and hospitals that could call into question the
      principle of solidarity, the secular values of ethics that govern the texts of
      law and ethics? In order to respond, we compared our experiences to a review of
      the professional and scientific literature from 1992 to 2010. Over the course of 
      the past eighteen years, health system organization was subjected to variations
      and significant tensions. These variations are witnesses to a paradigm shift:
      although a step towards the regionalization of the health system integrating the 
      choice of public health priorities, consultation and participatory democracy has 
      been implemented, nevertheless the system was then re-oriented towards the trend 
      of returning to centralization on the basis of uniting economics, technical
      modernization and contracting. This change of doctrine may undermine the social
      mission of hospitals and the principle of solidarity. Progress, the aging
      population and financial constraints would force policy-makers to steer the
      health system towards more centralized control. Hospitals, health professionals
      and users may feel torn within a system that tends to simplify and minimize what 
      is becoming increasingly complex and global. Benchmarks on values, ethics and law
      for the hospitals, healthcare professionals and users are questioned. These are
      important elements to consider when the law on the reform of hospitals, patients,
      health care and territories and regional health agencies is implemented.
FAU - Caillol, Michel
AU  - Caillol M
AD  - Chirurgien orthopediste et traumatologue, hopital Ambroise Pare, 1, rue d'Eylau, 
      13291 Marseille, France.
FAU - Le Coz, Pierre
AU  - Le Coz P
FAU - Aubry, Regis
AU  - Aubry R
FAU - Brechat, Pierre-Henri
AU  - Brechat PH
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Reformes du systeme de sante, contraintes economiques et valeurs ethiques,
      deontologiques et juridiques.
PL  - France
TA  - Sante Publique
JT  - Sante publique (Vandoeuvre-les-Nancy, France)
JID - 9216153
SB  - IM
MH  - Delivery of Health Care/*economics/*legislation & jurisprudence
MH  - Ethics, Medical
MH  - *Health Care Reform
MH  - Humans
MH  - *Public Health
EDAT- 2011/04/16 06:00
MHDA- 2011/05/26 06:00
CRDT- 2011/04/16 06:00
PHST- 2011/04/16 06:00 [entrez]
PHST- 2011/04/16 06:00 [pubmed]
PHST- 2011/05/26 06:00 [medline]
PST - ppublish
SO  - Sante Publique. 2010 Nov-Dec;22(6):625-36.


PMID- 21488472
OWN - NLM
STAT- MEDLINE
DCOM- 20110527
LR  - 20110414
IS  - 0300-5283 (Print)
IS  - 0300-5283 (Linking)
VI  - 65 Suppl A
DP  - 2010 Jun
TI  - The National Medical Research Register--a vital link between current and future
      research.
PG  - 124-7
AB  - Registration of research proposal to a publicly accessible website with
      searchable function allows information sharing and ensures research transparency.
      The National Institutes of Health Malaysia, realising the importance of research 
      registration, established the National Medical Research Register (NMRR) in 2007. 
      The NMRR functions more than just a local register: it also links to ethics
      approval and MOH medical research grant application. It thus facilitates
      researchers in their application to the Ministry of Health Research and Ethics
      Committee (MREC) and for Ministry of Health research grant. In addition, MREC
      committee members can review research protocol on NMRR website, thus saving much 
      time and resources. From May 2007 till December 2009, more than 3000 people have 
      registered as NMRR public users and more than 1000 research proposals have been
      uploaded in NMRR. The number of registration of research proposals, clinical
      trials and industrial sponsored trials steadily increased from year 2007 to year 
      2009. The web-based NMRR is the first research register in the world that links
      research proposal registration to ethical review and research grant application. 
      Its future plan is to be linked with publication. Therefore, it is indeed an
      innovation that Malaysians should be proud of.
FAU - Lim, T O
AU  - Lim TO
AD  - Clinical Research Centre, Ministry of Health Malaysia.
FAU - Asmaliza, S I
AU  - Asmaliza SI
FAU - Goh, P P
AU  - Goh PP
FAU - Michael, A J
AU  - Michael AJ
FAU - Hon, Y K
AU  - Hon YK
FAU - Thandapani, R
AU  - Thandapani R
FAU - Rahilah, A R Nur
AU  - Rahilah AR
FAU - Teoh, S C
AU  - Teoh SC
LA  - eng
PT  - Journal Article
PL  - Malaysia
TA  - Med J Malaysia
JT  - The Medical journal of Malaysia
JID - 0361547
SB  - IM
MH  - *Biomedical Research
MH  - *Clinical Trials as Topic
MH  - Malaysia
MH  - *Registries
EDAT- 2011/04/15 06:00
MHDA- 2011/05/28 06:00
CRDT- 2011/04/15 06:00
PHST- 2011/04/15 06:00 [entrez]
PHST- 2011/04/15 06:00 [pubmed]
PHST- 2011/05/28 06:00 [medline]
PST - ppublish
SO  - Med J Malaysia. 2010 Jun;65 Suppl A:124-7.


PMID- 21475717
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 1874-5490 (Print)
IS  - 1874-5490 (Linking)
VI  - 4
IP  - 1
DP  - 2011 Apr
TI  - Authenticity Anyone? The Enhancement of Emotions via Neuro-Psychopharmacology.
PG  - 51-64
AB  - This article will examine how the notion of emotional authenticity is intertwined
      with the notions of naturalness and artificiality in the context of the recent
      debates about 'neuro-enhancement' and 'neuro-psychopharmacology.' In the
      philosophy of mind, the concept of authenticity plays a key role in the
      discussion of the emotions. There is a widely held intuition that an artificial
      means will always lead to an inauthentic result. This article, however, proposes 
      that artificial substances do not necessarily result in inauthentic emotions. The
      literature provided by the philosophy of mind on this subject usually resorts to 
      thought experiments. On the other hand, the recent literature in applied ethics
      on 'enhancement' provides good reasons to include real world examples. Such case 
      studies reveal that some psychotropic drugs such as antidepressants actually
      cause people to undergo experiences of authenticity, making them feel 'like
      themselves' for the first time in their lives. Beginning with these accounts,
      this article suggests three non-naturalist standards for emotions: the
      authenticity standard, the rationality standard, and the coherence standard. It
      argues that the authenticity standard is not always the only valid one, but that 
      the other two ways of assessing emotions are also valid, and that they can even
      have repercussions on the felt authenticity of emotions. In conclusion, it
      sketches some of the normative implications if not ethical intricacies that
      accompany the enhancement of emotions.
FAU - Kraemer, Felicitas
AU  - Kraemer F
AD  - Section of Philosophy & Ethics, Eindhoven University of Technology, IPO 1.01, PO 
      Box 513, 5600 MB Eindhoven, The Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20100515
PL  - Netherlands
TA  - Neuroethics
JT  - Neuroethics
JID - 101468977
PMC - PMC3053456
EDAT- 2011/04/09 06:00
MHDA- 2011/04/09 06:01
CRDT- 2011/04/09 06:00
PHST- 2009/10/24 00:00 [received]
PHST- 2010/04/27 00:00 [accepted]
PHST- 2011/04/09 06:00 [entrez]
PHST- 2011/04/09 06:00 [pubmed]
PHST- 2011/04/09 06:01 [medline]
AID - 10.1007/s12152-010-9075-3 [doi]
PST - ppublish
SO  - Neuroethics. 2011 Apr;4(1):51-64. doi: 10.1007/s12152-010-9075-3. Epub 2010 May
      15.


PMID- 21475697
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 2190-5991 (Print)
IS  - 2190-5991 (Linking)
VI  - 1
IP  - 1
DP  - 2010 Sep
TI  - Ethical guidelines for authorship and publishing in the Journal of Cachexia,
      Sarcopenia and Muscle.
PG  - 7-8
AB  - The principles of ethical authorship and publishing in the Journal of Cachexia,
      Sarcopenia and Muscle (JCSM) are: all authors listed on the manuscript have
      approved its submission and publication as provided to JCSM;no person who has a
      right to be recognized as author has been omitted from the list of authors;each
      author has made an independent material contribution to the work submitted for
      publication;the submitted work is original and is neither under consideration
      elsewhere nor has it been published previously in whole or in part other than in 
      abstract form;all original research work is approved by the relevant bodies such 
      as institutional review boards or ethics committees;all conflicts of interest,
      financial or otherwise, that may affect the authors' ability to present data
      objectively have been duly declared in the manuscript;the manuscript in its
      published form will be maintained on the servers of JCSM as a valid publication
      only as long as all statements in the guidelines on ethical publishing remain
      true;if any of the aforementioned statements ceases to be true, the authors have 
      a duty to notify the editors of JCSM as soon as possible so that the information 
      available online can be updated and/or the manuscript can be withdrawn.
FAU - von Haehling, Stephan
AU  - von Haehling S
FAU - Morley, John E
AU  - Morley JE
FAU - Coats, Andrew J S
AU  - Coats AJ
FAU - Anker, Stefan D
AU  - Anker SD
LA  - eng
PT  - Journal Article
DEP - 20101026
PL  - Germany
TA  - J Cachexia Sarcopenia Muscle
JT  - Journal of cachexia, sarcopenia and muscle
JID - 101552883
PMC - PMC3060648
EDAT- 2011/04/09 06:00
MHDA- 2011/04/09 06:01
CRDT- 2011/04/09 06:00
PHST- 2011/04/09 06:00 [entrez]
PHST- 2011/04/09 06:00 [pubmed]
PHST- 2011/04/09 06:01 [medline]
AID - 10.1007/s13539-010-0003-5 [doi]
PST - ppublish
SO  - J Cachexia Sarcopenia Muscle. 2010 Sep;1(1):7-8. doi: 10.1007/s13539-010-0003-5. 
      Epub 2010 Oct 26.


PMID- 21475669
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220310
IS  - 1868-310X (Print)
IS  - 1868-310X (Linking)
VI  - 1
IP  - 3
DP  - 2010 Sep
TI  - Where are you going, where have you been: a recent history of the
      direct-to-consumer genetic testing market.
PG  - 101-106
AB  - In recent years, various private companies have been marketing and offering
      genetic tests directly to consumers. This article reviews the recent history of
      this commercial phenomenon. In particular, we discuss and describe the following 
      subjects: (1) the factors that allowed for the creation of the direct-to-consumer
      (DTC) genetic testing (GT) market; (2) information regarding the size and
      potential success or failure of the DTC GT market; (3) recent changes in the DTC 
      GT market; and (4) the recent events that may have an impact on the regulatory
      oversight of DTC genetic testing and the future evolution of this market. This
      review of factors suggests that despite the possibility of a change of business
      model as well as increased regulation, the commercialization of genetic testing
      is here to stay. As such it is important to pay close attention not only to the
      science underlying these tests but also to the ethical, legal, and social issues.
FAU - Borry, Pascal
AU  - Borry P
FAU - Cornel, Martina C
AU  - Cornel MC
FAU - Howard, Heidi C
AU  - Howard HC
LA  - eng
PT  - Journal Article
DEP - 20101008
PL  - Germany
TA  - J Community Genet
JT  - Journal of community genetics
JID - 101551501
PMC - PMC3063844
EDAT- 2011/04/09 06:00
MHDA- 2011/04/09 06:01
CRDT- 2011/04/09 06:00
PHST- 2010/08/18 00:00 [received]
PHST- 2010/09/24 00:00 [accepted]
PHST- 2011/04/09 06:00 [entrez]
PHST- 2011/04/09 06:00 [pubmed]
PHST- 2011/04/09 06:01 [medline]
AID - 10.1007/s12687-010-0023-z [doi]
PST - ppublish
SO  - J Community Genet. 2010 Sep;1(3):101-106. doi: 10.1007/s12687-010-0023-z. Epub
      2010 Oct 8.


PMID- 21472046
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1877-6566 (Electronic)
IS  - 1877-6558 (Linking)
VI  - 4
IP  - 1-4
DP  - 2010 Dec
TI  - Admixture mapping: from paradigms of race and ethnicity to population history.
PG  - 23-34
LID - 10.1007/s11568-010-9145-y [doi]
AB  - Admixture mapping is a whole genome association strategy that takes advantage of 
      population history-or genetic ancestry-to map genes for complex diseases.
      However, because it uses racial/ethnic groupings to examine differential disease 
      risk, admixture mapping raises ethical and social concerns. While there has been 
      much theoretical commentary regarding the ethical and social implications of
      population-based genetic research, empirical data from stakeholders most closely 
      involved with these studies is limited. One of the first admixture mapping
      studies carried out was a scan for Multiple Sclerosis (MS) risk factors in an
      African-American population. Applying qualitative research methods, we used this 
      example to explore developing views, experiences and perceptions of the ethical
      and social implications of admixture mapping and other population-based
      research-their value, risks and benefits, and the future prospects of the field. 
      Additionally, we sought to understand how social and ethical risks might be
      mitigated, and the benefits of this research optimized. We draw on in-depth,
      one-on-one interviews with leading population geneticists, genome scientists,
      bioethicists, and African-Americans with MS. Here we present our findings from
      this unique group of key informants and stakeholders.
FAU - Ali-Khan, Sarah E
AU  - Ali-Khan SE
FAU - Daar, Abdallah S
AU  - Daar AS
LA  - eng
PT  - Journal Article
DEP - 20100926
PL  - Netherlands
TA  - Hugo J
JT  - The HUGO journal
JID - 101530565
PMC - PMC3051047
OTO - NOTNLM
OT  - Admixture mapping
OT  - African-Americans
OT  - Ancestry
OT  - Multiple sclerosis
OT  - Population-based genetic research
OT  - Race
EDAT- 2011/04/08 06:00
MHDA- 2011/04/08 06:01
CRDT- 2011/04/08 06:00
PHST- 2010/03/24 00:00 [received]
PHST- 2010/08/26 00:00 [revised]
PHST- 2010/08/31 00:00 [accepted]
PHST- 2011/04/08 06:00 [entrez]
PHST- 2011/04/08 06:00 [pubmed]
PHST- 2011/04/08 06:01 [medline]
AID - 10.1007/s11568-010-9145-y [doi]
PST - ppublish
SO  - Hugo J. 2010 Dec;4(1-4):23-34. doi: 10.1007/s11568-010-9145-y. Epub 2010 Sep 26.


PMID- 21469515
OWN - NLM
STAT- MEDLINE
DCOM- 20110524
LR  - 20190608
IS  - 0379-8577 (Print)
IS  - 0379-8577 (Linking)
VI  - 33
IP  - 2
DP  - 2010 Jun
TI  - Perceptions of registered nurses in four state health insititutions on continuing
      formal education.
PG  - 41-50
AB  - This study investigated registered nurses in four selected state health
      institutions' perceptions with regard to continuing formal education. The
      relevance of continuing formal education is being emphasised globally by the
      increasing quest for quality assurance and quality management systems within an
      ethos of continuous improvement. According to Tlholoe (2006:5), it is important
      to be committed to continual learning, as people's knowledge become less relevant
      because skills gained early in a career are insufficient to avoid costly mistakes
      made through ignorance. Continuing formal education in nursing is a key element
      to the maintenance of quality in health care delivery. The study described:
      registered nurses' views on continuing formal education. Registered nurses'
      perceived barriers to continuing formal education. A quantitative descriptive
      survey design was chosen using a questionnaire for data collection. The sample
      consisted of 40 registered nurses working at four state health institutions in
      the Western Cape Province, South Africa. Convenience sampling was selected to
      include registered nurses who were on duty on the days during which the
      researcher visited the health institutions to distribute the questionnaires. The 
      questionnaire contained mainly closed-ended and a few open-ended questions.
      Content validity of the instrument was ensured by doing a thorough literature
      review before construction of items and a pretest. Reliability was established by
      the pretest and providing the same information to all respondents before
      completion of the questionnaires. The ethical considerations of informed consent,
      anonymity and confidentiality were adhered to and consent to conduct the study
      was obtained from relevant authorities. Descriptive statistics, based on
      calculations using the Microsoft (MS) Excel (for Windows 2000) programme, were
      used to summarise and describe the research results. The research results
      indicated that most registered nurses perceive continuing formal education as
      beneficial to their personal and professional growth and that it could lead
      towards improving the quality of patient/client care, but barriers exist which
      prevent or deter them from undertaking continuing formal education programmes.
      The main structural barriers included lack of funding and lack of coherent staff 
      development planning and physical barriers including job and family
      responsibilities.
FAU - Richards, L
AU  - Richards L
AD  - University of the Western Cape.
FAU - Potgieter, E
AU  - Potgieter E
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - Curationis
JT  - Curationis
JID - 7901092
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - *Education, Nursing, Continuing
MH  - Humans
MH  - Middle Aged
MH  - *Motivation
MH  - Nursing Staff, Hospital/*education/*psychology
MH  - South Africa
MH  - State Medicine
MH  - Surveys and Questionnaires
EDAT- 2011/04/08 06:00
MHDA- 2011/05/25 06:00
CRDT- 2011/04/08 06:00
PHST- 2011/04/08 06:00 [entrez]
PHST- 2011/04/08 06:00 [pubmed]
PHST- 2011/05/25 06:00 [medline]
AID - 10.4102/curationis.v33i2.1087 [doi]
PST - ppublish
SO  - Curationis. 2010 Jun;33(2):41-50. doi: 10.4102/curationis.v33i2.1087.


PMID- 21469512
OWN - NLM
STAT- MEDLINE
DCOM- 20110524
LR  - 20190608
IS  - 0379-8577 (Print)
IS  - 0379-8577 (Linking)
VI  - 33
IP  - 2
DP  - 2010 Jun
TI  - Perceptions of clients regarding family planning service delivery in a clinic of 
      the Greater Johannesburg Metropolitan Council.
PG  - 13-24
AB  - Unwanted pregnancies with their negative impact on both women and children occur 
      on an ongoing basis in Gauteng, South Africa. One way to prevent unwanted
      pregnancies is to use areliable contraceptive method available free of charge
      from primary health care clinics providing family planning services throughout
      Gauteng Province. A literature review was completed on women and access to family
      planning services and an interview schedule (questionnaire) was developed. The
      purpose of this study was to describe guidelines to meet the expectations of
      clients accessing family planning services provided by a clinic in Region F, Area
      28 of the Greater Johannesburg metropolitan council. This quantitative,
      exploratory, descriptive and comparative study measured the gaps between the
      expectations of participants on service delivery and the extent to which these
      expectations were met. A convenience sample was conducted and consisted of 50
      women of reproductive age (ages 15 to 49) attending the family planning clinic.
      Pre-testing of the instrument was conducted. Structured interviews with a
      interview schedule were conducted before and after women attended a family
      planning service. Inferential statistics indicated that there was a significant
      gap between the client expectations of family planning service delivery and the
      extent to which these expectations were met. Of the sixty-four items where women 
      indicated the extent of their expectations the findings on only three items were 
      not statistically significant. These gaps were addressed by proposing managerial 
      guidelines to be implemented by the nurse manager in charge of the facility, on
      which this article will focus. Validity and reliability principles were ensured
      in the study. Ethical principles were adhered to during the research process.
FAU - Kelner, A
AU  - Kelner A
AD  - Department of Nursing, University of Johannesburg, Auckland Park.
FAU - Jooste, K
AU  - Jooste K
FAU - Jacobs, W
AU  - Jacobs W
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - Curationis
JT  - Curationis
JID - 7901092
MH  - Adolescent
MH  - Adult
MH  - Ambulatory Care Facilities/*organization & administration/standards
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - *Patient Satisfaction
MH  - Practice Guidelines as Topic
MH  - South Africa
MH  - Transcultural Nursing/*organization & administration/standards
MH  - Urban Health Services/*organization & administration/standards
MH  - Young Adult
EDAT- 2011/04/08 06:00
MHDA- 2011/05/25 06:00
CRDT- 2011/04/08 06:00
PHST- 2011/04/08 06:00 [entrez]
PHST- 2011/04/08 06:00 [pubmed]
PHST- 2011/05/25 06:00 [medline]
AID - 10.4102/curationis.v33i2.1026 [doi]
PST - ppublish
SO  - Curationis. 2010 Jun;33(2):13-24. doi: 10.4102/curationis.v33i2.1026.


PMID- 21469459
OWN - NLM
STAT- MEDLINE
DCOM- 20110524
LR  - 20190608
IS  - 0379-8577 (Print)
IS  - 0379-8577 (Linking)
VI  - 33
IP  - 1
DP  - 2010 Mar
TI  - Infant feeding and HIV positive mothers in the Capricorn District of Limpopo
      province.
PG  - 5-16
AB  - HIV-positive mothers who practise infant feeding of their choice at Mankweng
      clinic in the Limpopo province are experiencing specific problems with various
      feeding methods. This study was undertaken with the aim to explore and describe
      the socioeconomic and cultural experiences of HIV-positive mothers who practise
      infant feeding of their choice. The research design was exploratory, descriptive,
      qualitative and contextual in nature. A phenomenological approach was adopted to 
      focus on the lived experiences of HIV-positive mothers. The study sample was
      purposely selected. Ten HIV-positive mothers volunteered to participate in the
      study. Data were collected through in-depth unstructured interviews. All
      participants responded to an open-ended question: "Could you please tell me, in
      detail, your experience on infant feeding of your choice?" Interviews were
      conducted until saturation, as was reflected in repeating themes, was reached.
      The model of trustworthiness, as outlined in Guba and Lincoln (1985:301-318), to 
      ensure credibility and dependability, was used in this study. The study adhered
      to the ethical standards as set by DENOSA (1998:2.3.2-2.3.4). Data were analysed 
      according to Tesch's method, as outlined in Creswell (2003:192) and De Vos
      (1998:343). Literature control was performed to verify the results. Two main
      categories that emerged were guided by options for infant feeding; namely those
      that chose formula feeding for their babies and those participants who opted to
      breast-feed their babies. The study proposed to recommend guidelines for the
      development of relevent content for inclusion in health education programmes of
      registered midwives who, in turn, can use such information to educate mothers.
FAU - Ramara, N S
AU  - Ramara NS
AD  - Nursing Department, University of Limpop (Turfloop Campus).
FAU - Maputle, M S
AU  - Maputle MS
FAU - Lekhuleni, M E
AU  - Lekhuleni ME
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - Curationis
JT  - Curationis
JID - 7901092
MH  - Adolescent
MH  - Adult
MH  - Breast Feeding/*ethnology
MH  - Child
MH  - Female
MH  - HIV Infections/*ethnology
MH  - Health Education/*methods
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Maternal-Child Nursing/*methods
MH  - South Africa
MH  - Transcultural Nursing/*methods
MH  - Young Adult
EDAT- 2011/04/08 06:00
MHDA- 2011/05/25 06:00
CRDT- 2011/04/08 06:00
PHST- 2011/04/08 06:00 [entrez]
PHST- 2011/04/08 06:00 [pubmed]
PHST- 2011/05/25 06:00 [medline]
AID - 10.4102/curationis.v33i1.1000 [doi]
PST - ppublish
SO  - Curationis. 2010 Mar;33(1):5-16. doi: 10.4102/curationis.v33i1.1000.


PMID- 21389760
OWN - NLM
STAT- MEDLINE
DCOM- 20110721
LR  - 20110310
IS  - 1423-0240 (Electronic)
IS  - 0378-584X (Linking)
VI  - 34 Suppl 1
DP  - 2011
TI  - [Ethics and economics in oncology].
PG  - 1
LID - 10.1159/000323062 [doi]
FAU - Winkler, Eva
AU  - Winkler E
FAU - Schildmann, Jan
AU  - Schildmann J
LA  - ger
PT  - Editorial
PT  - Introductory Journal Article
TT  - Ethik und Okonomie in der Onkologie.
DEP - 20101228
PL  - Switzerland
TA  - Onkologie
JT  - Onkologie
JID - 7808556
SB  - IM
MH  - Delivery of Health Care/*economics/*ethics
MH  - Germany
MH  - Health Care Rationing/*economics/*ethics
MH  - Humans
MH  - Medical Oncology/*economics/*ethics
MH  - Neoplasms/*economics
EDAT- 2011/04/08 06:00
MHDA- 2011/07/22 06:00
CRDT- 2011/03/11 06:00
PHST- 2011/03/11 06:00 [entrez]
PHST- 2011/04/08 06:00 [pubmed]
PHST- 2011/07/22 06:00 [medline]
AID - 000323062 [pii]
AID - 10.1159/000323062 [doi]
PST - ppublish
SO  - Onkologie. 2011;34 Suppl 1:1. doi: 10.1159/000323062. Epub 2010 Dec 28.


PMID- 21461465
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140612
LR  - 20191112
IS  - 1678-4758 (Electronic)
IS  - 0104-5970 (Linking)
VI  - 17
IP  - 4
DP  - 2010 Dec
TI  - [The imag-ethics of the individual].
PG  - 1028-30
LID - S0104-59702010000400012 [pii]
FAU - Victora, Ceres
AU  - Victora C
LA  - por
PT  - Journal Article
TT  - A imag-etica do individuo.
PL  - Brazil
TA  - Hist Cienc Saude Manguinhos
JT  - Historia, ciencias, saude--Manguinhos
JID - 9513999
EDAT- 2011/04/05 06:00
MHDA- 2011/04/05 06:01
CRDT- 2011/04/05 06:00
PHST- 2011/04/05 06:00 [entrez]
PHST- 2011/04/05 06:00 [pubmed]
PHST- 2011/04/05 06:01 [medline]
AID - S0104-59702010000400012 [pii]
AID - 10.1590/s0104-59702010000400012 [doi]
PST - ppublish
SO  - Hist Cienc Saude Manguinhos. 2010 Dec;17(4):1028-30. doi:
      10.1590/s0104-59702010000400012.


PMID- 21458743
OWN - NLM
STAT- MEDLINE
DCOM- 20110818
LR  - 20110404
IS  - 1526-0550 (Electronic)
IS  - 1526-0542 (Linking)
VI  - 12
IP  - 2
DP  - 2011 Jun
TI  - "Passage to Paradise" ethics and end-of-life decisions in children.
PG  - 139-43
LID - 10.1016/j.prrv.2010.10.003 [doi]
AB  - We describe our personal practice in the care of the dying child. There is no on 
      right model of care, and the multidisciplinary team must be sensitive to
      individual needs. It is important to get the balance of palliation and active
      treatment right (important at all stages of the illness). Key is careful planning
      by the whole multidisciplinary team and unhurried and frequent communication with
      the parents by a few key people. It is important to keep re-checking levels of
      understanding of the family; at times of stress, little information may be
      retained. Care should extend to the wider family and friends, and it is important
      also to consider the needs of hospital staff, both the immediate core team and
      beyond. Respect for religious and cultural issues is essential, but should not be
      allowed to interfere with optimum treatment of the child. The validity of
      different patterns of grieving should be acknowledged. Regular review is
      essential. There need to be open discussions about capping care, so that only
      appropriate interventions are given. This may be more difficult if the dying
      child is awaiting transplantation. The place of death (home, hospice, hospital)
      will be a matter of individual choice. After the death of the child, we offer
      follow up care for both the family and the staff.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Puckey, Michele
AU  - Puckey M
AD  - Paediatric Clinical Psychologist, Royal Brompton Hospital, Sydney Street, London 
      SW3 6NP, UK.
FAU - Bush, Andrew
AU  - Bush A
LA  - eng
PT  - Journal Article
DEP - 20101204
PL  - England
TA  - Paediatr Respir Rev
JT  - Paediatric respiratory reviews
JID - 100898941
SB  - IM
MH  - Caregivers/*psychology
MH  - Child
MH  - Decision Making/*ethics
MH  - *Ethics, Medical
MH  - Humans
MH  - Interdisciplinary Communication
MH  - Terminal Care/*ethics
EDAT- 2011/04/05 06:00
MHDA- 2011/08/19 06:00
CRDT- 2011/04/05 06:00
PHST- 2011/04/05 06:00 [entrez]
PHST- 2011/04/05 06:00 [pubmed]
PHST- 2011/08/19 06:00 [medline]
AID - S1526-0542(10)00097-7 [pii]
AID - 10.1016/j.prrv.2010.10.003 [doi]
PST - ppublish
SO  - Paediatr Respir Rev. 2011 Jun;12(2):139-43. doi: 10.1016/j.prrv.2010.10.003. Epub
      2010 Dec 4.


PMID- 21456302
OWN - NLM
STAT- MEDLINE
DCOM- 20110531
LR  - 20191112
IS  - 1145-0762 (Print)
IS  - 1145-0762 (Linking)
VI  - 21
IP  - 3
DP  - 2010 Sep
TI  - [Dignity and freedom: towards an insoluble contradiction?].
PG  - 17-27, 86
AB  - Dignity is a distinctive trait that our culture has chosen to attach to the
      individual. Dignity is an unconditional value and the prerogative of man. It goes
      without saying for us today that whatever his worldly status, his age, his sex,
      the colour of his skin, his state of health, etc, a man possesses dignity.
      However, from the point of view of history, nothing seems less spontaneous than
      to attribute to all men equal dignity. The idea of an ontological dignity, a
      dignity rooted in the depths of the human being, is the fruit of a long,
      laborious history which bears the mark of Judeo-Christian culture, of the
      philosophy of the age of Enlightenment, and of the international legal clauses
      that followed the atrocities committed during the second world war. Yet the
      semantic inflation of the concept, henceforth omnipresent in texts of law,
      society debates or ethical recommendations, threatens to make it sink into
      insignificance. Instead of enriching the argument, it becomes a pretext for not
      having to argue. A concept with an imprecise content, dignity has become through 
      time a sort of magic word which, in the name of ethics, makes it possible to
      defend any position and the contrary. Thus the dignity argument makes it possible
      to justify the depenalising of euthanasia (it would be an attempt on the dignity 
      of a being if he was refused the right to put an end to a life which is nothing
      but suffering) and its condemning (it would be an insult to a man's dignity if
      the only answer to his appeal for moral support was the administration of a
      lethal substance). Confused with the exercising of freedom or the quality of
      life, dignity has a regrettable tendency to cease to define an unconditional
      value; it has become a malleable, fluctuating property, sometimes even considered
      as related to living conditions or the state of physical and mental breakdown.
FAU - Le Coz, Pierre
AU  - Le Coz P
AD  - Faculte de medecine de Marseille (EA 3783).
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Dignite et liberte: vers une contradiction insoluble?
PL  - France
TA  - J Int Bioethique
JT  - Journal international de bioethique = International journal of bioethics
JID - 9015754
SB  - IM
MH  - Bioethical Issues
MH  - *Freedom
MH  - Humans
MH  - *Personhood
MH  - Right to Die
EDAT- 2011/04/05 06:00
MHDA- 2011/06/01 06:00
CRDT- 2011/04/05 06:00
PHST- 2011/04/05 06:00 [entrez]
PHST- 2011/04/05 06:00 [pubmed]
PHST- 2011/06/01 06:00 [medline]
AID - 10.3917/jib.213.0015 [doi]
PST - ppublish
SO  - J Int Bioethique. 2010 Sep;21(3):17-27, 86. doi: 10.3917/jib.213.0015.


PMID- 21455450
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 0974-925X (Electronic)
IS  - 0974-7788 (Linking)
VI  - 1
IP  - 4
DP  - 2010 Oct
TI  - Efficacy of Agnikarma over the padakanistakam (little toe) and Katibasti in
      Gridhrasi: A comparative study.
PG  - 223-30
LID - 10.4103/0974-7788.76786 [doi]
AB  - BACKGROUND AND OBJECTIVES: Gridhrasi (Sciatica) is one of the Vatavyadhi which is
      caused by aggravated Vata dosha. This disease is characterized by ruja (pain) in 
      the waist, back, thigh, knee and calf regions along the course of sciatic nerve. 
      In spite of the different types of treatment modalities mentioned in ancient and 
      modern medical sciences, they have some or the other shortcomings and drawbacks. 
      Considering all these, the present study was taken up with the objective of
      evaluating the efficacy of Agnikarma (treatment done with cauterization) over the
      padakanistakam (little toe) in the management of Gridhrasi. To consider the
      significance of the method of Agnikarma, the efficacy of Katibasti in the
      management of Gridhrasi which has been established in the previous work was also 
      studied. MATERIALS AND METHODS: The study was performed after obtaining Ethics
      Committee approval and patients' written informed consent. Forty cases presenting
      with classical features of Gridhrasi (Sciatica) due to lumbar intervertebral disc
      prolapse were selected. The management of Gridhrasi by Agnikarma and Katibasti
      was conducted by including the patients in two groups, namely Group A (study
      group) and Group B (control group). The data were collected and the observations 
      were made before the treatment, on 8(th) day, 15(th) day and on 22(nd) day of the
      treatment. The data obtained from the results were subjected for statistical
      analysis and conclusions were drawn. RESULTS: There was a significant reduction
      in the parameters, pain (P < 0.01) and straight-leg raising (SLR) test (P <
      0.01), of the study group compared to the control group (P < 0.01). Pain was
      assessed through Numerical Pain Analogue Scale. After the treatment with
      Agnikarma, the pain was totally relieved in 80% of cases. It was reduced to
      moderate degree in 20% of cases and in 95% of cases, SLR test became negative.
      After the treatment with Katibasti, the pain was totally relieved in 50% of
      cases. It was reduced to moderate degree in 20% and to mild degree in 25% of
      cases. In 60% of cases, SLR test became negative. However, changes in the
      radiological findings were not found in both the methods of management. Analysis 
      of overall effect of treatment in the present study reveals that Agnikarma was
      Both the procedures were conducted in to that of Katibasti. CONCLUSIONS: The
      management of Gridhrasi by Agnikarma was more efficacious as compared with
      Katibasti in reducing pain. However, there were no radiological changes produced 
      by both the methods of treatment. Further studies may be conducted by future
      scholars by taking more samples with more number of sittings.
FAU - Bali, Yogitha
AU  - Bali Y
AD  - Sri Jayachamarajendra Institute of Indian Medicine, Bangalore, India.
FAU - Vijayasarathi, R
AU  - Vijayasarathi R
FAU - Ebnezar, John
AU  - Ebnezar J
FAU - Venkatesh, Ba
AU  - Venkatesh B
LA  - eng
PT  - Journal Article
PL  - India
TA  - Int J Ayurveda Res
JT  - International journal of Ayurveda research
JID - 101527491
PMC - PMC3059445
OTO - NOTNLM
OT  - Agnikarma
OT  - Gridhrasi
OT  - Katibasthi
OT  - SLR test
OT  - lumbar intervertebral disc prolapse
OT  - padakanistakam
OT  - ruja
OT  - sciatic nerve
OT  - sciatica
EDAT- 2011/04/02 06:00
MHDA- 2011/04/02 06:01
CRDT- 2011/04/02 06:00
PHST- 2010/04/11 00:00 [received]
PHST- 2011/01/24 00:00 [accepted]
PHST- 2011/04/02 06:00 [entrez]
PHST- 2011/04/02 06:00 [pubmed]
PHST- 2011/04/02 06:01 [medline]
AID - 10.4103/0974-7788.76786 [doi]
PST - ppublish
SO  - Int J Ayurveda Res. 2010 Oct;1(4):223-30. doi: 10.4103/0974-7788.76786.


PMID- 21439868
OWN - NLM
STAT- MEDLINE
DCOM- 20111003
LR  - 20220408
IS  - 1545-1534 (Electronic)
IS  - 1080-6032 (Linking)
VI  - 22
IP  - 2
DP  - 2011 Jun
TI  - Athletic profile of highly accomplished boulderers.
PG  - 140-3
LID - 10.1016/j.wem.2010.11.012 [doi]
AB  - OBJECTIVE: Bouldering is a discipline of rock climbing completed at low height.
      Despite its popularity, scientific description of this sport remains sparse. This
      study aims to characterize the athletic profile of highly accomplished
      boulderers. METHODS: Twelve male highly accomplished boulderers (age 25.3 +/-
      4.9) were matched for age (+/- 5 yr), height (+/- 5 cm), and body mass (+/- 5 kg)
      to 12 nonclimbing aerobically trained controls. Body composition was determined
      by dual energy x-ray absorptiometry. Handgrip and climbing specific finger
      strength were assessed by dynamometry. Shoulder girdle and abdominal muscle
      endurance were assessed by isometric tests. Data were mostly analyzed by t-tests 
      with an adjusted alpha level for multiple comparisons. Ethical approval was
      received from the School of Sport, Health and Exercise Sciences, Bangor
      University, Bangor, UK. RESULTS: Body composition was similar between the groups,
      apart from increased bone mineral density in climbers' forearms (1.1 +/- 0.1 vs. 
      1.0 +/- 0.1 g.cm(2), t((22))=2.798, p=0.010). Hand grip strength and climbing
      specific finger strength were greater in climbers (eg, finger strength: 494 +/-
      64 vs. 383 +/- 79 N, t((22))=3.740, p=0.001), but handgrip and abdominal
      endurance were similar between the groups. In contrast, endurance of the shoulder
      girdle was substantially greater in boulderers (58 +/- 13 vs. 39 +/- 9 s,
      t((22))=4.044, p=0.001). CONCLUSION: Highly accomplished boulderers were
      characterized by handgrip and finger strength better than that of nonclimbing
      controls and superior to that of previously investigated elite climbers. In
      contrast, boulderers' body composition and core endurance were similar to that of
      controls (who were aerobically trained). These characteristics provide an
      athletic profile of highly accomplished boulderers, and hence identify possible
      targets that with further investigation may aid athlete selection and training
      program design.
CI  - Copyright (c) 2011 Wilderness Medical Society. Published by Elsevier Inc. All
      rights reserved.
FAU - Macdonald, Jamie H
AU  - Macdonald JH
AD  - Extremes Research Group, School of Sport, Health and Exercise Sciences, Bangor
      University, Bangor, UK. j.h.macdonald@bangor.ac.uk
FAU - Callender, Nigel
AU  - Callender N
LA  - eng
PT  - Journal Article
DEP - 20101129
PL  - United States
TA  - Wilderness Environ Med
JT  - Wilderness & environmental medicine
JID - 9505185
SB  - IM
MH  - Abdominal Muscles/*physiology
MH  - Absorptiometry, Photon
MH  - Adult
MH  - *Body Composition
MH  - Cross-Sectional Studies
MH  - Exercise Test
MH  - Fingers/*physiology
MH  - *Hand Strength
MH  - Humans
MH  - Male
MH  - Mountaineering/*physiology
MH  - Physical Examination
MH  - Reference Values
MH  - Shoulder/*physiology
MH  - Young Adult
EDAT- 2011/03/29 06:00
MHDA- 2011/10/04 06:00
CRDT- 2011/03/29 06:00
PHST- 2010/06/30 00:00 [received]
PHST- 2010/10/30 00:00 [revised]
PHST- 2010/11/23 00:00 [accepted]
PHST- 2011/03/29 06:00 [entrez]
PHST- 2011/03/29 06:00 [pubmed]
PHST- 2011/10/04 06:00 [medline]
AID - S1080-6032(10)00376-5 [pii]
AID - 10.1016/j.wem.2010.11.012 [doi]
PST - ppublish
SO  - Wilderness Environ Med. 2011 Jun;22(2):140-3. doi: 10.1016/j.wem.2010.11.012.
      Epub 2010 Nov 29.


PMID- 21438305
OWN - NLM
STAT- MEDLINE
DCOM- 20110817
LR  - 20110325
IS  - 1592-7830 (Print)
IS  - 1592-7830 (Linking)
VI  - 32
IP  - 4 Suppl
DP  - 2010 Oct-Dec
TI  - [Methodology and results of an experience of medical surveillance of people
      previously exposed to asbestos in Tuscany].
PG  - 385-8
AB  - Although medical surveillance of workers previously exposed to asbestos has been 
      made mandatory by several laws since 1991 (recently confirmed by the law 81/08), 
      neither the subject encharged of it nor the medical protocols have been yet
      established. In the absence of a specific regulation different medical protocols 
      have been proposed by several centers often with no respect of ethical or
      radioprotectionist principles, such as some screening programs exclusively based 
      on radiologic exams. With the aim of setting up a secondary preventive health
      program according both to a correct ethical and economic cost-effective balance, 
      we followed up a cohort of 647 workers. The medical protocol included a physical 
      exam, functional respiratory tests, thoracic Xray and low dose CT scans along
      with some experimental biologic markers such as mesothelin and osteopontin. All
      the mentioned tests were periodically administered to asbestos workers according 
      to the individual level of risk. This risk-modulated preventive medical protocol 
      allowed us to diagnose respiratory diseases in up to 39% of the investigated
      population, 2/3 of which were classified as asbestos-related occupational
      diseases. In conclusion our data suggest that the integration of different kind
      of exams, with limited use of radiology, is effective in the medical follow-up of
      asbestos-exposed workers. Regional health politics should begin to take into
      account this reported evidence.
FAU - Cristaudo, A
AU  - Cristaudo A
AD  - U.O. Medicina Preventiva del Lavoro, AOUP/Dipartimento di Endocrinologia,
      Metabolismo, Ortopedia, Traumatologia e Medicina del Lavoro, Universita di Pisa, 
      Italy.
FAU - Foddis, R
AU  - Foddis R
FAU - Guglielmi, G
AU  - Guglielmi G
LA  - ita
PT  - English Abstract
PT  - Journal Article
TT  - Metodologia e risultati di una esperienza toscana di sorveglianza sanitaria di
      ex-esposti.
PL  - Italy
TA  - G Ital Med Lav Ergon
JT  - Giornale italiano di medicina del lavoro ed ergonomia
JID - 9712708
RN  - 1332-21-4 (Asbestos)
SB  - IM
MH  - Asbestos/*adverse effects
MH  - Asbestosis/*diagnosis/*etiology
MH  - Humans
MH  - Italy
MH  - Occupational Exposure/*adverse effects
MH  - *Population Surveillance
MH  - Time Factors
EDAT- 2011/03/29 06:00
MHDA- 2011/08/19 06:00
CRDT- 2011/03/29 06:00
PHST- 2011/03/29 06:00 [entrez]
PHST- 2011/03/29 06:00 [pubmed]
PHST- 2011/08/19 06:00 [medline]
PST - ppublish
SO  - G Ital Med Lav Ergon. 2010 Oct-Dec;32(4 Suppl):385-8.


PMID- 21438267
OWN - NLM
STAT- MEDLINE
DCOM- 20110817
LR  - 20110325
IS  - 1592-7830 (Print)
IS  - 1592-7830 (Linking)
VI  - 32
IP  - 4 Suppl
DP  - 2010 Oct-Dec
TI  - [Workplace and laws: from health prevention to health promotion].
PG  - 222-5
AB  - DLgs 626/94 adopted European Directives and changed the Italian field of safety
      and health at work: it set out minimum requirements and fundamental principles,
      such as the principle of prevention and risk assessment, as well as the
      responsibilities of employers and employees. The actual DLgs 81/08 introduced in 
      the workplace the health promotion idea with the aim to promote, protect and
      maintain health, considering workers' safety and health as social and ethic
      issues.
FAU - Isolani, L
AU  - Isolani L
AD  - ASUR MARCHE ZT9 Macerata, Servizio Prevenzione Sicurezza Ambienti di Lavoro,
      Macerata, Italy. lucia.isolani@gmail.com
LA  - ita
PT  - English Abstract
PT  - Journal Article
TT  - L'evoluzione normativa e i riflessi sulla tutela del lavoratore: dalla
      prevenzione nei luoghi di lavoro alla promozione della salute.
PL  - Italy
TA  - G Ital Med Lav Ergon
JT  - Giornale italiano di medicina del lavoro ed ergonomia
JID - 9712708
SB  - IM
MH  - Health Promotion/*legislation & jurisprudence
MH  - Humans
MH  - Italy
MH  - Occupational Diseases/*prevention & control
MH  - Occupational Health/*legislation & jurisprudence
EDAT- 2011/03/29 06:00
MHDA- 2011/08/19 06:00
CRDT- 2011/03/29 06:00
PHST- 2011/03/29 06:00 [entrez]
PHST- 2011/03/29 06:00 [pubmed]
PHST- 2011/08/19 06:00 [medline]
PST - ppublish
SO  - G Ital Med Lav Ergon. 2010 Oct-Dec;32(4 Suppl):222-5.


PMID- 21438225
OWN - NLM
STAT- MEDLINE
DCOM- 20110817
LR  - 20110325
IS  - 1592-7830 (Print)
IS  - 1592-7830 (Linking)
VI  - 32
IP  - 4 Suppl
DP  - 2010 Oct-Dec
TI  - [Occupational health practice among law, evidence and ethics: a field study].
PG  - 83-7
AB  - BACKGROUND: Quality in health care is defined as the degree to which health
      services increase the likelihood of desired health outcomes and are consistent
      with the law, the evidence and the ethical values. MATERIALS AND METHODS: The
      paper aims at providing a framework in which the concept of quality is applied in
      the field of occupational health by analysing real-life decisions. RESULTS: The
      Italian law states that the practice must be evidence-based and respectful of the
      code of ethics, emphasizeing that the practice should be relevant,
      knowledge-based, sound and appropriate. Any dilemma should be dealt according to 
      the ethical principles of beneficience, autonomy and justice. Both the law and
      the code require that the practice is based on the available evidence. Results
      show that decisions in selected cases can be made according the above mentioned
      criteria. CONCLUSION; Decisions made on the basis of a process founded on
      scientific evidence result in effective and high-quality outcomes respectful of
      both law and ethics.
FAU - Franco, G
AU  - Franco G
AD  - Dipartimento di Medicine e delle Specialita mediche, Universita di Modena e
      Reggio Emilia, Modena, Italy. franco@unimo.it
FAU - Mora, E
AU  - Mora E
LA  - ita
PT  - English Abstract
PT  - Journal Article
TT  - La pratica professionale del medico del lavoro tra norme, prove scientifiche ed
      etica professionale: un'esperienza sul campo.
PL  - Italy
TA  - G Ital Med Lav Ergon
JT  - Giornale italiano di medicina del lavoro ed ergonomia
JID - 9712708
SB  - IM
MH  - Evidence-Based Medicine
MH  - Humans
MH  - Occupational Medicine/*ethics/*legislation & jurisprudence/standards
EDAT- 2011/03/29 06:00
MHDA- 2011/08/19 06:00
CRDT- 2011/03/29 06:00
PHST- 2011/03/29 06:00 [entrez]
PHST- 2011/03/29 06:00 [pubmed]
PHST- 2011/08/19 06:00 [medline]
PST - ppublish
SO  - G Ital Med Lav Ergon. 2010 Oct-Dec;32(4 Suppl):83-7.


PMID- 21438223
OWN - NLM
STAT- MEDLINE
DCOM- 20110817
LR  - 20110325
IS  - 1592-7830 (Print)
IS  - 1592-7830 (Linking)
VI  - 32
IP  - 4 Suppl
DP  - 2010 Oct-Dec
TI  - [Quality in occupational health education and training].
PG  - 71-4
AB  - According to the International Code of Ethics of the International Commission on 
      Occupational Health (ICOH) "occupational health practice must be performed
      according to the highest professional standards and ethical principles". So, the 
      first ethical requirement for an occupational physician is a scientifically and
      professionally sound conduct, and vice-versa, the ethical principles must be an
      integral part of his/her education and training. The different tools and contexts
      for the education and training in occupational health (OH) in Italy, at both the 
      undergraduate and postgraduate level, are presented. Moreover, the past and
      present contribution of the academic institutions and professional associations
      active in occupational health, to improve the professional standards of the
      occupational physicians is discussed. It is suggested that the objectives and the
      contents in OH education and training should not be limited to simply fulfil the 
      legal requirements aimed to the protection of health and safety in the workplace 
      (as it seems to be largely the case today), but they should rather anticipate and
      overcome them, by also including a thorough discussion of the fundamental ethical
      principles and duties to be accomplished in OH.
FAU - Manno, M
AU  - Manno M
AD  - Dipartimento di Scienze Mediche Preventive, Universita degli Studi di Napoli
      Federico II, Napoli, Italy. maurizio.manno@unina.it
LA  - ita
PT  - English Abstract
PT  - Journal Article
TT  - La qualita della formazione in medicina del lavoro.
PL  - Italy
TA  - G Ital Med Lav Ergon
JT  - Giornale italiano di medicina del lavoro ed ergonomia
JID - 9712708
SB  - IM
MH  - Italy
MH  - Occupational Medicine/*education
EDAT- 2011/03/29 06:00
MHDA- 2011/08/19 06:00
CRDT- 2011/03/29 06:00
PHST- 2011/03/29 06:00 [entrez]
PHST- 2011/03/29 06:00 [pubmed]
PHST- 2011/08/19 06:00 [medline]
PST - ppublish
SO  - G Ital Med Lav Ergon. 2010 Oct-Dec;32(4 Suppl):71-4.


PMID- 21438222
OWN - NLM
STAT- MEDLINE
DCOM- 20110817
LR  - 20110325
IS  - 1592-7830 (Print)
IS  - 1592-7830 (Linking)
VI  - 32
IP  - 4 Suppl
DP  - 2010 Oct-Dec
TI  - [The ICOH International Code of Ethics for Occupational Health Professionals].
PG  - 68-70
AB  - In the paper all the steps are described which are followed by ICOH to finalize
      the International Code of Ethics for Occupational Health Professionals (OHP). The
      Code is composed by a "Preface" in which is explained why the Occupational Health
      Professionals need a specific Code different from other Codes built up for
      general practitioners or other specializations, followed by an "Introduction"
      where the targets of Occupational Health are underlined and which professionals
      contribute to achieve the defined target. These two parts are followed by a more 
      substantial description of the tasks and duties of the OHP. In the last part of
      the Code it is illustrated how to carry out the above mentioned duties. The
      principles inserted in the ICOH Code of Ethics have been worldwide accepted by
      the OHP and particularly in Italy where they have been included in the
      Legislative Decree 81/08.
FAU - Foa, V
AU  - Foa V
AD  - Direttore de La Medicina del Lavoro, Universita degli Studi di Milano.
      vito.foa@alice.it
LA  - ita
PT  - English Abstract
PT  - Journal Article
TT  - Il codice etico dell'LCOH per gli operatori di Medicina del Lavoro.
PL  - Italy
TA  - G Ital Med Lav Ergon
JT  - Giornale italiano di medicina del lavoro ed ergonomia
JID - 9712708
SB  - IM
MH  - *Codes of Ethics
MH  - Humans
MH  - *International Agencies
MH  - Occupational Medicine/*ethics
EDAT- 2011/03/29 06:00
MHDA- 2011/08/19 06:00
CRDT- 2011/03/29 06:00
PHST- 2011/03/29 06:00 [entrez]
PHST- 2011/03/29 06:00 [pubmed]
PHST- 2011/08/19 06:00 [medline]
PST - ppublish
SO  - G Ital Med Lav Ergon. 2010 Oct-Dec;32(4 Suppl):68-70.


PMID- 21438206
OWN - NLM
STAT- MEDLINE
DCOM- 20110817
LR  - 20110325
IS  - 1592-7830 (Print)
IS  - 1592-7830 (Linking)
VI  - 32
IP  - 4 Suppl
DP  - 2010 Oct-Dec
TI  - [Role of the occupational physician in occupational injuries prevention: across
      ethics, science and good practices].
PG  - 14-7
AB  - Occupational injuries (OI) are a relevant issue in workplaces, being responsible 
      for a range of individual and socio-economic consequences, with an enormous toll 
      paid by workers, enterprises and society. Despite all these issues, OI prevention
      has not received significant field research attention, with studies mainly
      addressed to reporting data a posteriori instead of evaluating the effectiveness 
      of prevention programs. In addition, the role of occupational physician (OP)
      seems to be largely underplayed. OP may and should be involved in OI prevention
      and control, in respect of codes of ethics, current legislation and scientific
      evidence. A multifaceted intervention in foundries, which showed effectiveness in
      reducing OI rates and improving quantitative and qualitative outcomes, gave us
      the opportunity to highlight OP's key role in implementing good occupational
      health and safety practices in workplaces.
FAU - Porru, S
AU  - Porru S
AD  - Sezione di Medicina del Lavoro, Universita degli Studi di Brescia, Brescia,
      Italy. porru@med.unibs.it
FAU - Arici, C
AU  - Arici C
FAU - Fostinelli, J
AU  - Fostinelli J
FAU - Alessio, L
AU  - Alessio L
LA  - ita
PT  - English Abstract
PT  - Journal Article
TT  - Ruolo del medico competente nella prevenzione degli infortuni sul lavoro: tra
      etica, scienza e buone prassi.
PL  - Italy
TA  - G Ital Med Lav Ergon
JT  - Giornale italiano di medicina del lavoro ed ergonomia
JID - 9712708
SB  - IM
MH  - Accidents, Occupational/*prevention & control
MH  - Humans
MH  - *Occupational Health
MH  - Occupational Medicine/*ethics
MH  - *Physician's Role
MH  - Wounds and Injuries/*prevention & control
EDAT- 2011/03/29 06:00
MHDA- 2011/08/19 06:00
CRDT- 2011/03/29 06:00
PHST- 2011/03/29 06:00 [entrez]
PHST- 2011/03/29 06:00 [pubmed]
PHST- 2011/08/19 06:00 [medline]
PST - ppublish
SO  - G Ital Med Lav Ergon. 2010 Oct-Dec;32(4 Suppl):14-7.


PMID- 21436925
OWN - NLM
STAT- MEDLINE
DCOM- 20120214
LR  - 20211020
IS  - 1553-6467 (Electronic)
IS  - 0002-9459 (Linking)
VI  - 74
IP  - 10
DP  - 2010 Dec 15
TI  - Legal and ethical issues regarding social media and pharmacy education.
PG  - 184
AB  - Widespread use of social media applications like Facebook, YouTube, and Twitter
      has introduced new complexities to the legal and ethical environment of higher
      education. Social communications have traditionally been considered private;
      however, now that much of this information is published online to the public,
      more insight is available to students' attitudes, opinions, and character.
      Pharmacy educators and administrators may struggle with the myriad of ethical and
      legal issues pertaining to social media communications and relationships with and
      among students. This article seeks to clarify some of these issues with a review 
      of the legal facets and pertinent court cases related to social media. In
      addition, 5 core ethical issues are identified and discussed. The article
      concludes with recommendations for pharmacy educators with regard to preparing
      for and addressing potential legal issues pertaining to social media.
FAU - Cain, Jeff
AU  - Cain J
AD  - University of Kentucky College of Pharmacy, Lexington, KY 40536-0596, USA.
      jjcain00@email.uky.edu
FAU - Fink, Joseph L
AU  - Fink JL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Pharm Educ
JT  - American journal of pharmaceutical education
JID - 0372650
SB  - IM
MH  - Education, Pharmacy/*ethics/*legislation & jurisprudence
MH  - Ethics, Pharmacy/education
MH  - Humans
MH  - Internet/*ethics/*legislation & jurisprudence
MH  - *Interpersonal Relations
MH  - Students/legislation & jurisprudence
MH  - Students, Pharmacy/*legislation & jurisprudence
PMC - PMC3058471
OTO - NOTNLM
OT  - eprofessionalism
OT  - ethics
OT  - law
OT  - social media
OT  - technology
EDAT- 2011/03/26 06:00
MHDA- 2012/02/15 06:00
CRDT- 2011/03/26 06:00
PHST- 2010/06/17 00:00 [received]
PHST- 2010/08/23 00:00 [accepted]
PHST- 2011/03/26 06:00 [entrez]
PHST- 2011/03/26 06:00 [pubmed]
PHST- 2012/02/15 06:00 [medline]
AID - 10.5688/aj7410184 [doi]
PST - ppublish
SO  - Am J Pharm Educ. 2010 Dec 15;74(10):184. doi: 10.5688/aj7410184.


PMID- 21434516
OWN - NLM
STAT- MEDLINE
DCOM- 20110817
LR  - 20110325
IS  - 1592-7830 (Print)
IS  - 1592-7830 (Linking)
VI  - 32
IP  - 4 Suppl
DP  - 2010 Oct-Dec
TI  - Biomonitoring and health surveillance: ethical challenges.
PG  - 79-82
FAU - Van Damme, K
AU  - Van Damme K
AD  - Center for Human Genetics, University of Leuven, Belgium.
      karel.vandamme@med.kuleuven.be
FAU - Casteleyn, L
AU  - Casteleyn L
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - G Ital Med Lav Ergon
JT  - Giornale italiano di medicina del lavoro ed ergonomia
JID - 9712708
SB  - IM
MH  - Clinical Chemistry Tests/*ethics
MH  - Humans
MH  - *Occupational Health
MH  - Occupational Medicine/*ethics
MH  - *Population Surveillance
EDAT- 2011/03/26 06:00
MHDA- 2011/08/19 06:00
CRDT- 2011/03/26 06:00
PHST- 2011/03/26 06:00 [entrez]
PHST- 2011/03/26 06:00 [pubmed]
PHST- 2011/08/19 06:00 [medline]
PST - ppublish
SO  - G Ital Med Lav Ergon. 2010 Oct-Dec;32(4 Suppl):79-82.


PMID- 21431804
OWN - NLM
STAT- MEDLINE
DCOM- 20110809
LR  - 20211020
IS  - 1347-4715 (Electronic)
IS  - 1342-078X (Linking)
VI  - 16
IP  - 3
DP  - 2011 May
TI  - Does the Japanese Society for Hygiene need its own Code of Conduct? A comparison 
      of the responses of councilors and junior members based on a questionnaire
      survey.
PG  - 178-84
LID - 10.1007/s12199-010-0175-9 [doi]
AB  - OBJECTIVE: The purpose of this study was to compare current awareness of the "On 
      a Code of Conduct for Scientists" (OCCS) among members of the Japanese Society
      for Hygiene (JSH). METHOD: An anonymous self-administered questionnaire was
      mailed to JSH members, including 439 councilors and 376 junior members (who were 
      under 50 years of age with a membership of 3 years or longer, excluding
      councilors). Councilors were surveyed from November to December 2007, while
      junior members were surveyed from November to December 2008. RESULTS: The overall
      response rate was 40.6% (n = 331/815), with responses from 46.7% of the
      councilors (n = 205/439) and 33.5% of the junior members (n = 126/376). Among the
      respondents, 36.0% of councilors (n = 68) and 59.8% of junior members (n = 73)
      did not know the contents of "On the Code of Conduct for Scientists" (P < 0.01), 
      while 76.3% of councilors (n = 145) and 61.4% of junior members (n = 75) had not 
      heard of it (P < 0.05). However, a majority of the respondents reported interest 
      in the Code [70.0% of councilors (n = 133), 68.6% of junior members (n = 83)] (P 
      < 0.05) and a favorable attitude towards research ethics education [69.3% of
      councilors (n = 133), 68.9% of junior members (n = 84)] (P < 0.54). In addition, 
      24.3% of the responding councilors (n = 46) and 15.7% of the responding junior
      members (n = 19) believe it necessary for JSH to formulate its own code of
      conduct for scientists (P < 0.01). CONCLUSION: We clarified the current state of 
      awareness of the OCCS among JSH members as well as the opinion of members for the
      JSH to have its own Code of Conduct for Scientists. This result provides
      important information that should be considered during the formulation of an
      individual code of conduct for scientists in the JSH.
FAU - Ikeda, Wakaha
AU  - Ikeda W
AD  - Department of Epidemiology and Environmental Health, Juntendo University Faculty 
      of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
      wakaha@juntendo.ac.jp
FAU - Inaba, Yutaka
AU  - Inaba Y
FAU - Takeshita, Tatsuya
AU  - Takeshita T
FAU - Yoshida, Katsumi
AU  - Yoshida K
FAU - Ogoshi, Kumiko
AU  - Ogoshi K
FAU - Okamoto, Kazushi
AU  - Okamoto K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100923
PL  - Japan
TA  - Environ Health Prev Med
JT  - Environmental health and preventive medicine
JID - 9609642
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - *Codes of Ethics
MH  - *Ethics, Professional
MH  - Female
MH  - Health Personnel/psychology
MH  - Humans
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Public Health/*ethics
MH  - Societies/*ethics/organization & administration
MH  - Surveys and Questionnaires
PMC - PMC3078295
EDAT- 2011/03/25 06:00
MHDA- 2011/08/10 06:00
CRDT- 2011/03/25 06:00
PHST- 2010/05/17 00:00 [received]
PHST- 2010/07/29 00:00 [accepted]
PHST- 2011/03/25 06:00 [entrez]
PHST- 2011/03/25 06:00 [pubmed]
PHST- 2011/08/10 06:00 [medline]
AID - 10.1007/s12199-010-0175-9 [doi]
PST - ppublish
SO  - Environ Health Prev Med. 2011 May;16(3):178-84. doi: 10.1007/s12199-010-0175-9.
      Epub 2010 Sep 23.


PMID- 21423824
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220318
IS  - 1750-8592 (Print)
IS  - 1750-8592 (Linking)
VI  - 4
IP  - 1
DP  - 2010 Apr 1
TI  - Developing Multiple Language Versions of Instruments for Intercultural Research.
PG  - 19-24
AB  - This article examines the strengths and weaknesses of several translation
      techniques currently in use through the lens of emerging opinions on the science 
      and ethics of intercultural research. Broad scientific and ethical dimensions
      relevant to translating instruments and a distinction between generating multiple
      language forms of two kinds of instruments are introduced: those in which wording
      in the source language cannot be altered and those in which constraints of the
      target language can lead to changes in the original instrument's wording.
      Developmental psychologists engaged in intercultural research can consider
      techniques for minimizing the influence of Western perspectives while pursuing
      conceptual equivalence in order to satisfy science's concern for internal
      validity of translated instruments.
FAU - Erkut, Sumru
AU  - Erkut S
AD  - Wellesley Centers for Women.
LA  - eng
GR  - R01 HD030592-03/HD/NICHD NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Child Dev Perspect
JT  - Child development perspectives
JID - 101469707
PMC - PMC3060794
MID - NIHMS273189
EDAT- 2011/03/23 06:00
MHDA- 2011/03/23 06:01
CRDT- 2011/03/23 06:00
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2011/03/23 06:01 [medline]
AID - 10.1111/j.1750-8606.2009.00111.x [doi]
PST - ppublish
SO  - Child Dev Perspect. 2010 Apr 1;4(1):19-24. doi: 10.1111/j.1750-8606.2009.00111.x.


PMID- 21414856
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110729
LR  - 20110318
IS  - 1873-7560 (Electronic)
IS  - 0302-2838 (Linking)
VI  - 58
IP  - 5
DP  - 2010 Nov
TI  - Words of wisdom. Re: Biological, clinical, and ethical advances of placebo
      effects.
PG  - 792-3
LID - 10.1016/j.eururo.2010.08.018 [doi]
FAU - Salonia, Andrea
AU  - Salonia A
AD  - Department of Urology, University Vita-Salute San Raffaele, Via Olgettina 60,
      20132 Milan, Italy. salonia.andrea@hsr.it
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - Switzerland
TA  - Eur Urol
JT  - European urology
JID - 7512719
CON - Lancet. 2010 Feb 20;375(9715):686-95. PMID: 20171404
EDAT- 2011/03/19 06:00
MHDA- 2011/03/19 06:01
CRDT- 2011/03/19 06:00
PHST- 2011/03/19 06:00 [entrez]
PHST- 2011/03/19 06:00 [pubmed]
PHST- 2011/03/19 06:01 [medline]
AID - S0302-2838(10)00749-9 [pii]
AID - 10.1016/j.eururo.2010.08.018 [doi]
PST - ppublish
SO  - Eur Urol. 2010 Nov;58(5):792-3. doi: 10.1016/j.eururo.2010.08.018.


PMID- 21413488
OWN - NLM
STAT- MEDLINE
DCOM- 20110503
LR  - 20211020
IS  - 1470-2118 (Print)
IS  - 1470-2118 (Linking)
VI  - 10
IP  - 6
DP  - 2010 Dec
TI  - Ethics and artificial nutrition towards the end of life.
PG  - 607-10
FAU - Jones, Barry J M
AU  - Jones BJ
AD  - Russells Hall Hospital, Dudley. b.j.m.j@btinternet.com
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Clin Med (Lond)
JT  - Clinical medicine (London, England)
JID - 101092853
SB  - IM
MH  - *Attitude of Health Personnel
MH  - *Ethics, Medical
MH  - Humans
MH  - Nutritional Support/*ethics
MH  - Terminal Care/ethics/*methods
PMC - PMC4951871
EDAT- 2011/03/19 06:00
MHDA- 2011/05/04 06:00
CRDT- 2011/03/19 06:00
PHST- 2011/03/19 06:00 [entrez]
PHST- 2011/03/19 06:00 [pubmed]
PHST- 2011/05/04 06:00 [medline]
AID - 10.7861/clinmedicine.10-6-607 [doi]
PST - ppublish
SO  - Clin Med (Lond). 2010 Dec;10(6):607-10. doi: 10.7861/clinmedicine.10-6-607.


PMID- 21409983
OWN - NLM
STAT- MEDLINE
DCOM- 20110503
LR  - 20191112
IS  - 0021-1753 (Print)
IS  - 0021-1753 (Linking)
VI  - 101
IP  - 4
DP  - 2010 Dec
TI  - After the fall: Political whitewashing, professional posturing, and personal
      refashioning in the postwar career of Otmar Freiherr von Verschuer.
PG  - 722-58
AB  - Despite the numerous books and articles preoccupied with the formidable
      legitimizing role and unethical medical transgressions of the German human
      geneticist Otmar von Verschuer (1896-1969) during the Third Reich, scholars have 
      neglected to focus on his career trajectory during the postwar period, especially
      in the years after he received the first chair of genetics on German soil in
      1951. While an examination of von Verschuer's trials, tribulations, and ultimate 
      triumph in post-1945 West Germany is fascinating in its own right, it also raises
      broader historical issues. First, it lays bare the professional posturing of
      German biomedical scientists as they attempted to retake control over their once 
      tainted fields of research when Cold War realities opened a window of opportunity
      for them. Second, it reveals the fine line between adherence to professional
      ethics and disciplinary solidarity when scientists were faced with a potential
      outside threat to their profession. Finally, such an analysis demonstrates the
      macromechanics of professional refashioning on the part of the publicly tainted
      scientists as they forged a new symbiosis between their field and the politics of
      a new era in the interest of pursuing research.
FAU - Weiss, Sheila Faith
AU  - Weiss SF
AD  - Department of Humanities and Social Sciences, Clarkson University, Potsdam, New
      York 13699-5750, USA.
LA  - eng
PT  - Biography
PT  - Historical Article
PT  - Journal Article
PT  - Portrait
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Isis
JT  - Isis; an international review devoted to the history of science and its cultural 
      influences
JID - 2985182R
SB  - IM
MH  - Academies and Institutes/history
MH  - Concentration Camps/history
MH  - Eugenics/history
MH  - Genetic Research/*ethics/*history
MH  - Germany
MH  - Germany, West
MH  - History, 20th Century
MH  - Human Experimentation/*ethics/*history
MH  - Humans
MH  - Male
MH  - National Socialism/history
MH  - Politics
MH  - Religion and Science
MH  - World War II
PS  - von Verschuer OF
FPS - von Verschuer, Otmar Freiherr
EDAT- 2011/03/18 06:00
MHDA- 2011/05/04 06:00
CRDT- 2011/03/18 06:00
PHST- 2011/03/18 06:00 [entrez]
PHST- 2011/03/18 06:00 [pubmed]
PHST- 2011/05/04 06:00 [medline]
AID - 10.1086/657474 [doi]
PST - ppublish
SO  - Isis. 2010 Dec;101(4):722-58. doi: 10.1086/657474.


PMID- 21409299
OWN - NLM
STAT- MEDLINE
DCOM- 20110705
LR  - 20191210
IS  - 1813-4424 (Electronic)
IS  - 1729-0376 (Linking)
VI  - 7
IP  - 3
DP  - 2010 Oct
TI  - The role of community advisory boards in health research: Divergent views in the 
      South African experience.
PG  - 2-8
AB  - In the light of the growing involvement of community advisory boards (CABs) in
      health research, this study presents empirical findings of the functions and
      operations of CABs in HIV/AIDS vaccine trials in South Africa. The individual and
      focus group interviews with CAB members, principal investigators, research staff,
      community educators, recruiters, ethics committee members, trial participants and
      South African AIDS Vaccine Initiative (SAAVI) staff members demonstrated
      differences in the respondents' perceptions of the roles and responsibilities of 
      CABs. These findings question the roles of the CABs. Are they primarily there to 
      serve and be accountable to the community, or to serve the accomplishment of the 
      research objectives? Four emergent themes are discussed here: purpose; membership
      and representation; power and authority; sources of support and independence. The
      CABs' primary purpose carries significant implications for a wide range of issues
      regarding their functioning. The dual functions of advancing the research and
      protecting the community appear to be fraught with tension, and require careful
      reconsideration.
FAU - Reddy, Priscilla
AU  - Reddy P
AD  - Health Promotion Research and Development Unit of the Medical Research Council,
      South Africa.
FAU - Buchanan, David
AU  - Buchanan D
FAU - Sifunda, Sibusiso
AU  - Sifunda S
FAU - James, Shamagonam
AU  - James S
FAU - Naidoo, Nasheen
AU  - Naidoo N
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - SAHARA J
JT  - SAHARA J : journal of Social Aspects of HIV/AIDS Research Alliance
JID - 101226212
RN  - 0 (AIDS Vaccines)
SB  - IM
MH  - *AIDS Vaccines
MH  - *Advisory Committees/organization & administration
MH  - *Clinical Trials as Topic/methods
MH  - Committee Membership
MH  - Community Participation/*methods
MH  - *Community-Institutional Relations
MH  - Dissent and Disputes
MH  - Focus Groups
MH  - Goals
MH  - Health Services Research/*organization & administration
MH  - Humans
MH  - Information Dissemination
MH  - Patient Selection
MH  - Policy Making
MH  - Power, Psychological
MH  - Role
MH  - Social Responsibility
MH  - South Africa
EDAT- 2011/03/17 06:00
MHDA- 2011/07/06 06:00
CRDT- 2011/03/17 06:00
PHST- 2011/03/17 06:00 [entrez]
PHST- 2011/03/17 06:00 [pubmed]
PHST- 2011/07/06 06:00 [medline]
AID - 10.1080/17290376.2010.9724963 [doi]
PST - ppublish
SO  - SAHARA J. 2010 Oct;7(3):2-8. doi: 10.1080/17290376.2010.9724963.


PMID- 21404876
OWN - NLM
STAT- MEDLINE
DCOM- 20110408
LR  - 20191112
IS  - 0334-0139 (Print)
IS  - 0334-0139 (Linking)
VI  - 22
IP  - 4
DP  - 2010 Oct-Dec
TI  - Ethical considerations in transition.
PG  - 453-9
AB  - The objective of this paper is to explore ethical issues in the provision of
      transitional care. Using five case studies a number of ethical issues in
      transition and transition care are discussed. These issues include: 1)
      preserving, promoting and ensuring dignity and respect for patients; 2) fostering
      and supporting the trusting relationships that young people and their parents
      have for pediatric providers to their new adult providers by using a graduated
      system of transfer; 3) recognizing graduated capacity; 4) promoting autonomy and 
      self-management; 5) duties of beneficence and non-maleficence; 6) truthtelling;
      7) duty to provide developmentally appropriate care; and 8) duty of pediatric
      providers to advocate for transitioning patients in the adult system. Attention
      to the ethical issues surrounding these complex cases has the potential to
      positively influence a successful transition to adult-oriented health care.
FAU - Kaufman, Hannah
AU  - Kaufman H
AD  - Bioethics Program, University Health Network, Toronto, Ontario, Canada.
      kaufman.hannah@gmail.com
FAU - Horricks, Laurie
AU  - Horricks L
FAU - Kaufman, Miriam
AU  - Kaufman M
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Int J Adolesc Med Health
JT  - International journal of adolescent medicine and health
JID - 8506960
SB  - IM
MH  - *Adaptation, Psychological
MH  - Adolescent
MH  - Adolescent Health Services/*ethics
MH  - Chronic Disease/psychology/*therapy
MH  - Continuity of Patient Care/*ethics
MH  - Female
MH  - Humans
MH  - Male
MH  - Patient Advocacy
MH  - Pediatrics/*ethics
MH  - Personal Autonomy
MH  - Self Care
MH  - Trust
MH  - Young Adult
EDAT- 2011/03/17 06:00
MHDA- 2011/04/09 06:00
CRDT- 2011/03/17 06:00
PHST- 2011/03/17 06:00 [entrez]
PHST- 2011/03/17 06:00 [pubmed]
PHST- 2011/04/09 06:00 [medline]
AID - 10.1515/ijamh.2010.22.4.453 [doi]
PST - ppublish
SO  - Int J Adolesc Med Health. 2010 Oct-Dec;22(4):453-9. doi:
      10.1515/ijamh.2010.22.4.453.


PMID- 21404750
OWN - NLM
STAT- MEDLINE
DCOM- 20110408
LR  - 20131121
IS  - 0019-5847 (Print)
IS  - 0019-5847 (Linking)
VI  - 108
IP  - 8
DP  - 2010 Aug
TI  - Isolated ascites in hypothyroidism: medical and ethical issues.
PG  - 523-4
AB  - Hypothyroidism presenting as ascites is one of the rarest clinical scenarios
      encountered in medical practice. A case of a 65-year-old woman, presenting with
      progressive onset ascites, secondary to underlying hypothyroidism, which
      responded to thyroid hormone replacement therapy is reported. A feature of
      hypothyroidism Induced ascites is the high protein content of the ascitic fluid
      (> 2.5 g/dl), a high serum albumin ascites gradient (SAAG) and the consistent
      drastic response of ascites to thyroid hormone replacement. Hypothyroid ascites
      is thus a very rare manifestation of the primary disease, but should be borne in 
      mind when other causes of ascites are ruled out and the ascitic fluid shows
      typical features.
FAU - Philips, Cyriac Abby
AU  - Philips CA
AD  - Department of General Medicine, Nilratan Sircar Medical College, Kolkata 700014.
FAU - Sinha, Uma
AU  - Sinha U
FAU - Chattopadhyay, Partha
AU  - Chattopadhyay P
FAU - Mukhopadhyay, Prasanta
AU  - Mukhopadhyay P
FAU - Haldar, Swaraj
AU  - Haldar S
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - India
TA  - J Indian Med Assoc
JT  - Journal of the Indian Medical Association
JID - 7505608
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Aged
MH  - Ascites/diagnosis/drug therapy/*etiology
MH  - Diagnostic Errors/ethics/prevention & control
MH  - Female
MH  - Humans
MH  - Hypothyroidism/*complications/drug therapy
MH  - India
MH  - Thyroxine/therapeutic use
EDAT- 2011/03/17 06:00
MHDA- 2011/04/09 06:00
CRDT- 2011/03/17 06:00
PHST- 2011/03/17 06:00 [entrez]
PHST- 2011/03/17 06:00 [pubmed]
PHST- 2011/04/09 06:00 [medline]
PST - ppublish
SO  - J Indian Med Assoc. 2010 Aug;108(8):523-4.


PMID- 21275480
OWN - NLM
STAT- MEDLINE
DCOM- 20110329
LR  - 20190518
IS  - 0261-1929 (Print)
IS  - 0261-1929 (Linking)
VI  - 38 Suppl 1
DP  - 2010 Dec
TI  - The use of functional human tissues in drug development.
PG  - 27-30
AB  - Drug development currently depends on animal models to provide an accurate
      prediction of human physiology and pathophysiology. However, as is clear from
      clinical trial failures during phases II and III, such in vivo models do not
      always predict the effects that a drug can elicit in humans. Tests with human
      tissues, which are obviously considered to be the closest model of human in vivo 
      function, could fill the gap between animal-based tests and trials in patients.
      Despite clear advantages, logistical and ethical barriers prevent fresh human
      tissues from being widely used during drug development. Biopta is aiming to make 
      human tissue testing a regular element of drug development, and works to lower
      the barriers surrounding the availability of tissue and practicalities of
      experimental work.
CI  - 2010 FRAME.
FAU - Bunton, David
AU  - Bunton D
AD  - Biopta Ltd, Glasgow, UK. davidbunton@biopta.com
LA  - eng
PT  - Journal Article
PL  - England
TA  - Altern Lab Anim
JT  - Alternatives to laboratory animals : ATLA
JID - 8110074
SB  - IM
MH  - *Animal Testing Alternatives
MH  - *Drug Discovery/trends
MH  - Humans
MH  - *Tissue and Organ Procurement
EDAT- 2011/03/16 06:00
MHDA- 2011/03/30 06:00
CRDT- 2011/02/01 06:00
PHST- 2011/02/01 06:00 [entrez]
PHST- 2011/03/16 06:00 [pubmed]
PHST- 2011/03/30 06:00 [medline]
AID - 10.1177/026119291003801S05 [doi]
PST - ppublish
SO  - Altern Lab Anim. 2010 Dec;38 Suppl 1:27-30. doi: 10.1177/026119291003801S05.


PMID- 21393292
OWN - NLM
STAT- MEDLINE
DCOM- 20110715
LR  - 20110311
IS  - 1473-4265 (Electronic)
IS  - 1468-215X (Linking)
VI  - 36
IP  - 2
DP  - 2010 Dec
TI  - Deliver us from evil: carer burden in Alzheimer's disease.
PG  - 101-7
LID - 10.1136/jmh.2010.004697 [doi]
AB  - Alzheimer's disease is the most common neurodegenerative disorder in today's
      developed world that is also increasingly picked out as a focal theme in
      fictional literature. In dealing with the subjectivity of human experience, such 
      literature enhances the reader's empathy and is able to teach about moral,
      emotional and philosophical issues, offering the chance to see situations from a 
      position otherwise possibly never taken by the reader. The understanding and
      insight so gained may well be unscientific, but the literary approach offers an
      insight into the whole person's perspective and the particularity and uniqueness 
      of a situation that includes ethical conflicts. A key motif of fictional
      literature centred around dementia remains the burden the adult-child carer is
      confronted with, considering the parent's remorseless decline and personality
      change, the sudden demand for devoted and continuous care, and the constantly
      changing relationship with the declining parent. In the context of an ever
      increasing demand for a constructive public discussion regarding end-of-life
      treatment of demented patients, Christine Devars (Le Piano Desaccorde) and Andres
      Barba (Ahora Tocad Musica de Baile) illustrate how powerful and burdensome the
      impact of Alzheimer's disease is on both patient and carer and what extremes may 
      be reached under such truly exceptional circumstances.
FAU - Zimmermann, Martina
AU  - Zimmermann M
AD  - Department of Pharmacology, School of Pharmacy, Biocentre N260, Max-von-Laue Str 
      9, Goethe University Frankfurt am Main, 60438 Frankfurt am Main, Germany.
      martina.zimmermann@em.uni-frankfurt.de
LA  - eng
PT  - Journal Article
DEP - 20101024
PL  - United States
TA  - Med Humanit
JT  - Medical humanities
JID - 100959585
SB  - IM
MH  - Adult
MH  - Adult Children/psychology
MH  - Alzheimer Disease/*psychology
MH  - Caregivers/*psychology
MH  - *Cost of Illness
MH  - Dementia/psychology
MH  - Humans
MH  - *Medicine in Literature
MH  - Parent-Child Relations
MH  - Terminal Care/psychology
EDAT- 2011/03/12 06:00
MHDA- 2011/07/16 06:00
CRDT- 2011/03/12 06:00
PHST- 2011/03/12 06:00 [entrez]
PHST- 2011/03/12 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
AID - jmh.2010.004697 [pii]
AID - 10.1136/jmh.2010.004697 [doi]
PST - ppublish
SO  - Med Humanit. 2010 Dec;36(2):101-7. doi: 10.1136/jmh.2010.004697. Epub 2010 Oct
      24.


PMID- 21393289
OWN - NLM
STAT- MEDLINE
DCOM- 20110715
LR  - 20110311
IS  - 1473-4265 (Electronic)
IS  - 1468-215X (Linking)
VI  - 36
IP  - 2
DP  - 2010 Dec
TI  - Diagnostic reasoning in Nizami 'Aruzi's Four Discourses.
PG  - 88-92
LID - 10.1136/jmh.2010.004572 [doi]
AB  - BACKGROUND: Most studies on medical reasoning focus on contemporary allopathic
      practitioners. Here, the significance of diagnostic sense in Nizami 'Aruzi's Four
      Discourses (Chahar Maqale), an influential text that circulated widely throughout
      the Islamic world, is explored. METHODS: After a brief introduction, key passages
      are translated on how doctors should cultivate analytical skills. RESULTS: Nizami
      'Aruzi cites three sources of diagnostic authority: (1) education in the texts of
      medical experts, (2) formal logic and (3) belief in the power of God.
      CONCLUSIONS: 'Aruzi's methods, though rooted in a religious faith that may seem
      foreign to contemporary doctors and educators, has much to recommend regarding
      its clarity of approach, its high ethical standards and expectations of doctors, 
      and its commitment to best practices for the patient. Crosscultural studies of
      medical education and professionalism can offer valuable insights by
      demonstrating how doctors across history and geography have grappled with the
      common concerns of diagnosis and treatment.
FAU - Aggarwal, Neil Krishan
AU  - Aggarwal NK
AD  - Department of Psychiatry, Yale University, New Haven, Connecticut, USA.
      neil.aggarwal@yale.edu
LA  - eng
PT  - Journal Article
DEP - 20101030
PL  - United States
TA  - Med Humanit
JT  - Medical humanities
JID - 100959585
SB  - IM
MH  - Diagnosis, Differential
MH  - *Education, Medical
MH  - Humans
MH  - Logic
MH  - *Problem Solving
MH  - *Reference Books, Medical
MH  - Religion and Medicine
MH  - Textbooks as Topic
EDAT- 2011/03/12 06:00
MHDA- 2011/07/16 06:00
CRDT- 2011/03/12 06:00
PHST- 2011/03/12 06:00 [entrez]
PHST- 2011/03/12 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
AID - jmh.2010.004572 [pii]
AID - 10.1136/jmh.2010.004572 [doi]
PST - ppublish
SO  - Med Humanit. 2010 Dec;36(2):88-92. doi: 10.1136/jmh.2010.004572. Epub 2010 Oct
      30.


PMID- 21393288
OWN - NLM
STAT- MEDLINE
DCOM- 20110715
LR  - 20211020
IS  - 1473-4265 (Electronic)
IS  - 1468-215X (Linking)
VI  - 36
IP  - 2
DP  - 2010 Dec
TI  - 'Patient trade' in Germany: an ethical issue at the practitioner--clinician
      interface in 1909 and 2009.
PG  - 84-7
LID - 10.1136/jmh.2010.004655 [doi]
AB  - In 2009 the German media featured the so-called 'patient trade' scandal.
      Offending against the rules of the professional code for German doctors, some
      medical practitioners had accepted bonus payments from specific hospitals for
      referring patients to them. This article discusses a historical precedent for
      this scandal, the patient trade affair of 1909, in which several medical
      professors of the Berlin university clinics were accused of having paid agents
      for bringing them lucrative private patients. Although the historical contexts
      were different, then, as in 2009, a commercial attitude towards medical practice 
      clashed with the ethical ideal of the economically disinterested doctor.
FAU - Maehle, Andreas-Holger
AU  - Maehle AH
AD  - Centre for the History of Medicine and Disease, Wolfson Research Institute,
      Durham University, Queen's Campus, Stockton TS17 6BH, UK. a.h.maehle@durham.ac.uk
LA  - eng
GR  - 082800/Wellcome Trust/United Kingdom
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101115
PL  - United States
TA  - Med Humanit
JT  - Medical humanities
JID - 100959585
SB  - IM
MH  - Academic Medical Centers/economics/*ethics
MH  - Berlin
MH  - Ethics, Medical/*history
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Physician-Patient Relations/*ethics
MH  - Referral and Consultation/economics/*ethics/history
PMC - PMC3793241
MID - EMS55069
OID - NLM: EMS55069
EDAT- 2011/03/12 06:00
MHDA- 2011/07/16 06:00
CRDT- 2011/03/12 06:00
PHST- 2011/03/12 06:00 [entrez]
PHST- 2011/03/12 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
AID - jmh.2010.004655 [pii]
AID - 10.1136/jmh.2010.004655 [doi]
PST - ppublish
SO  - Med Humanit. 2010 Dec;36(2):84-7. doi: 10.1136/jmh.2010.004655. Epub 2010 Nov 15.


PMID- 21393282
OWN - NLM
STAT- MEDLINE
DCOM- 20110715
LR  - 20191210
IS  - 1473-4265 (Electronic)
IS  - 1468-215X (Linking)
VI  - 36
IP  - 2
DP  - 2010 Dec
TI  - MEDLINE indexing and trying to understand the ethical constraints inherent in
      publishing people's stories: two milestones in the medical humanities journey.
PG  - 65-6
LID - 10.1136/jmh.2010.006460 [doi]
FAU - Kirklin, Deborah
AU  - Kirklin D
LA  - eng
PT  - Editorial
PL  - United States
TA  - Med Humanit
JT  - Medical humanities
JID - 100959585
SB  - IM
MH  - Abstracting and Indexing
MH  - *Humanities
MH  - Humans
MH  - MEDLINE
MH  - *Periodicals as Topic
MH  - Publishing/ethics
EDAT- 2011/03/12 06:00
MHDA- 2011/07/16 06:00
CRDT- 2011/03/12 06:00
PHST- 2011/03/12 06:00 [entrez]
PHST- 2011/03/12 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
AID - 36/2/65 [pii]
AID - 10.1136/jmh.2010.006460 [doi]
PST - ppublish
SO  - Med Humanit. 2010 Dec;36(2):65-6. doi: 10.1136/jmh.2010.006460.


PMID- 21381627
OWN - NLM
STAT- MEDLINE
DCOM- 20110607
LR  - 20110308
IS  - 0030-9982 (Print)
IS  - 0030-9982 (Linking)
VI  - 60
IP  - 10
DP  - 2010 Oct
TI  - Should doctors and patients be friends? Can this lead to an ethical dilemma?
PG  - 875-6
FAU - Gadit, Amin A Muhammad
AU  - Gadit AA
AD  - Memorial University of Newfoundland, Canada.
LA  - eng
PT  - Journal Article
PL  - Pakistan
TA  - J Pak Med Assoc
JT  - JPMA. The Journal of the Pakistan Medical Association
JID - 7501162
SB  - IM
MH  - *Ethics, Medical
MH  - *Friends
MH  - Humans
MH  - Interpersonal Relations
MH  - Patients/psychology
MH  - *Physician-Patient Relations
MH  - Physicians/*psychology
EDAT- 2011/03/09 06:00
MHDA- 2011/06/08 06:00
CRDT- 2011/03/09 06:00
PHST- 2011/03/09 06:00 [entrez]
PHST- 2011/03/09 06:00 [pubmed]
PHST- 2011/06/08 06:00 [medline]
AID - 2347 [pii]
PST - ppublish
SO  - J Pak Med Assoc. 2010 Oct;60(10):875-6.


PMID- 21381571
OWN - NLM
STAT- MEDLINE
DCOM- 20110317
LR  - 20220317
IS  - 0030-9982 (Print)
IS  - 0030-9982 (Linking)
VI  - 60
IP  - 9
DP  - 2010 Sep
TI  - Medical ethics: a slow but sustained revolution in Pakistan's healthcare.
PG  - 706-7
FAU - Shamim, Muhammad Shahid
AU  - Shamim MS
FAU - Shamim, Muhammad Shahzad
AU  - Shamim MS
LA  - eng
PT  - Editorial
PL  - Pakistan
TA  - J Pak Med Assoc
JT  - JPMA. The Journal of the Pakistan Medical Association
JID - 7501162
SB  - IM
CIN - J Pak Med Assoc. 2011 Apr;61(4):407-8. PMID: 21465989
MH  - Delivery of Health Care/*ethics
MH  - Education, Medical
MH  - *Ethics, Medical
MH  - Humans
MH  - Pakistan
EDAT- 2011/03/09 06:00
MHDA- 2011/03/18 06:00
CRDT- 2011/03/09 06:00
PHST- 2011/03/09 06:00 [entrez]
PHST- 2011/03/09 06:00 [pubmed]
PHST- 2011/03/18 06:00 [medline]
AID - 2282 [pii]
PST - ppublish
SO  - J Pak Med Assoc. 2010 Sep;60(9):706-7.


PMID- 21381564
OWN - NLM
STAT- MEDLINE
DCOM- 20110609
LR  - 20110308
IS  - 0030-9982 (Print)
IS  - 0030-9982 (Linking)
VI  - 60
IP  - 12
DP  - 2010 Dec
TI  - Stranded in the web of evidence and ethics.
PG  - 1060-3
FAU - Hyder, Qurratulain
AU  - Hyder Q
AD  - Department of Gastroenterology-Hepatology, Pakistan Institute of Medical Sciences
      (PIMS), Islamabad, Pakistan.
FAU - Zhang, Ziuli
AU  - Zhang Z
FAU - Li, Wen
AU  - Li W
FAU - Liu, Xiaochuan
AU  - Liu X
LA  - eng
PT  - Journal Article
PL  - Pakistan
TA  - J Pak Med Assoc
JT  - JPMA. The Journal of the Pakistan Medical Association
JID - 7501162
SB  - IM
MH  - *Evidence-Based Medicine
MH  - Humans
MH  - Natural Orifice Endoscopic Surgery/*ethics
EDAT- 2011/03/09 06:00
MHDA- 2011/06/10 06:00
CRDT- 2011/03/09 06:00
PHST- 2011/03/09 06:00 [entrez]
PHST- 2011/03/09 06:00 [pubmed]
PHST- 2011/06/10 06:00 [medline]
AID - 2465 [pii]
PST - ppublish
SO  - J Pak Med Assoc. 2010 Dec;60(12):1060-3.


PMID- 21381551
OWN - NLM
STAT- MEDLINE
DCOM- 20110609
LR  - 20191210
IS  - 0030-9982 (Print)
IS  - 0030-9982 (Linking)
VI  - 60
IP  - 12
DP  - 2010 Dec
TI  - An experience of capsule endoscopy from a tertiary care hospital in Pakistan.
PG  - 1001-5
AB  - OBJECTIVES: To evaluate the effectiveness of capsule endoscopy in the management 
      of patients with obscure gastrointestinal bleeding. METHODS: A prospective
      descriptive study was conducted at surgical unit IV, Civil Hospital Karachi over 
      a period of 2 years from December 2007 to November 2009. Twenty eight consecutive
      patients presenting with obscure gastrointestinal bleeding were included in the
      study. Patients having history of acute intestinal obstruction were excluded.
      Study was approved by the hospital ethical committee. Informed and written
      consent was taken from all the patients included in the study. The procedure was 
      performed as day case. Patients were asked to swallow a capsule with a glass of
      water after an overnight fast and bowel preparation. Endocapsule (Olympus
      MAJ-1469) was used in the study. Examination was termed as complete when the
      capsule reached the caecum or incomplete if capsule failed to enter the caecum or
      the battery life was exhausted. Computer recordings were read by two examiners
      and finally results were interpreted. Follow up was done on telephone every 24
      hours till the passage of capsule and then monthly for 4 months. In case of
      failure to pass the capsule after 14 days or adverse effects like vomiting,
      abdominal pain, an abdominal radiograph was obtained and decision regarding
      surgical intervention was made. RESULTS: A total of twenty eight patients were
      included in this study, 15 (53.6%) males and 13 (46.4%) females. Age of the
      patients ranged from 15-85 years (mean 56.25 +/- 19.6 years). There were 8
      (28.6%) diabetics, 8 (28.6%) hypertensives and 5 (17.9%) hepatitis C positive
      patients. The indication for the capsule endoscopy was malena in 9 (32.1%),
      occult bleed in 18 (64.3%) and non specific abdominal pain in 1 (3.6%).
      Examination was completed in 22/28 (78.6%) patients while 6 (21.4%) patients had 
      incomplete examination. In 2/28 (7.1%) patients endoscopic assistance was
      required to push the capsule through the pylorus. There was history of abdominal 
      surgery in 3/28 (10.7%) patients prior to capsule endoscopy. Capsule entrapment
      occurred in 2/28 (7.1%) patients who were subjected to surgery. The results of
      capsule endoscopy showed ulceration and bleeding in distal ileum in 7 patients
      followed by Arterio Venous Malformation in 6 patients. The management and follow 
      up was done accordingly. CONCLUSION: The diagnostic yield of CE in this study was
      64.28% (18/28 patients). In a total of 28 patients referred for capsule
      endoscopy, bleeding was resolved in 13 patients (46.42%). Capsule endoscopy is a 
      well tolerated and safe examination of the small bowel with a diagnostic yield
      superior to radiological investigations.
FAU - Qureshi, Sajida
AU  - Qureshi S
AD  - Department of Surgery, Dow University of Health Science, Civil Hospital, Karachi.
FAU - Ghazanfar, Shahriyar
AU  - Ghazanfar S
FAU - Dawood, Altaf
AU  - Dawood A
FAU - Zubair, Muhammad
AU  - Zubair M
FAU - Leghari, Aftab
AU  - Leghari A
FAU - Niaz, Saad Khalid
AU  - Niaz SK
FAU - Quraishy, Mohammed Saeed
AU  - Quraishy MS
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - Pakistan
TA  - J Pak Med Assoc
JT  - JPMA. The Journal of the Pakistan Medical Association
JID - 7501162
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Capsule Endoscopy
MH  - Female
MH  - Follow-Up Studies
MH  - Gastrointestinal Hemorrhage/*diagnosis/etiology
MH  - Hospitals, University
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pakistan
MH  - Prospective Studies
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2011/03/09 06:00
MHDA- 2011/06/10 06:00
CRDT- 2011/03/09 06:00
PHST- 2011/03/09 06:00 [entrez]
PHST- 2011/03/09 06:00 [pubmed]
PHST- 2011/06/10 06:00 [medline]
AID - 2452 [pii]
PST - ppublish
SO  - J Pak Med Assoc. 2010 Dec;60(12):1001-5.


PMID- 21375114
OWN - NLM
STAT- MEDLINE
DCOM- 20110401
LR  - 20220316
IS  - 0193-7758 (Print)
IS  - 0193-7758 (Linking)
VI  - 32
IP  - 6
DP  - 2010 Nov-Dec
TI  - Enhancing research ethics decision-making: an REB decision bank.
PG  - 9-12
FAU - Bean, Sally
AU  - Bean S
AD  - Sunnybrook Health Sciences Center and The University of Toronto, Joint Centre for
      Bioethics, ON, Canada.
FAU - Henry, Blair
AU  - Henry B
FAU - Kinsey, J Michelle
AU  - Kinsey JM
FAU - McMurray, Keitha
AU  - McMurray K
FAU - Parry, Catherine
AU  - Parry C
FAU - Tassopoulos, Tiffany
AU  - Tassopoulos T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - IRB
JT  - IRB
JID - 7906878
SB  - IM
MH  - Databases, Factual/*ethics
MH  - Decision Making/*ethics
MH  - *Decision Support Techniques
MH  - Ethics Committees, Research/*ethics
MH  - *Ethics, Research
MH  - Humans
EDAT- 2011/03/08 06:00
MHDA- 2011/04/02 06:00
CRDT- 2011/03/08 06:00
PHST- 2011/03/08 06:00 [entrez]
PHST- 2011/03/08 06:00 [pubmed]
PHST- 2011/04/02 06:00 [medline]
PST - ppublish
SO  - IRB. 2010 Nov-Dec;32(6):9-12.


PMID- 21375113
OWN - NLM
STAT- MEDLINE
DCOM- 20110401
LR  - 20110307
IS  - 0193-7758 (Print)
IS  - 0193-7758 (Linking)
VI  - 32
IP  - 6
DP  - 2010 Nov-Dec
TI  - Research with decisionally incapacitated older adults: practices of Canadian
      research ethics boards.
PG  - 1-8
FAU - Bravo, Gina
AU  - Bravo G
AD  - Department of Community Health Sciences, University of Sherbrooke, Canada.
FAU - Dubois, Marie-France
AU  - Dubois MF
FAU - Wildeman, Sheila M
AU  - Wildeman SM
FAU - Graham, Janice E
AU  - Graham JE
FAU - Cohen, Carole A
AU  - Cohen CA
FAU - Painter, Karen
AU  - Painter K
FAU - Bellemare, Suzanne
AU  - Bellemare S
LA  - eng
GR  - 200409MOP/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - IRB
JT  - IRB
JID - 7906878
SB  - IM
MH  - Adult
MH  - Advance Directives
MH  - Aged
MH  - Canada
MH  - *Dementia
MH  - Ethics Committees, Research
MH  - *Ethics, Research
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Male
MH  - *Mental Competency
MH  - Middle Aged
MH  - Research Design
MH  - Third-Party Consent/*ethics
EDAT- 2011/03/08 06:00
MHDA- 2011/04/02 06:00
CRDT- 2011/03/08 06:00
PHST- 2011/03/08 06:00 [entrez]
PHST- 2011/03/08 06:00 [pubmed]
PHST- 2011/04/02 06:00 [medline]
PST - ppublish
SO  - IRB. 2010 Nov-Dec;32(6):1-8.


PMID- 21374968
OWN - NLM
STAT- MEDLINE
DCOM- 20120216
LR  - 20110304
IS  - 1001-5515 (Print)
IS  - 1001-5515 (Linking)
VI  - 27
IP  - 6
DP  - 2010 Dec
TI  - [A clinical study of cardiac reserve mobilizing condition for pregnant women].
PG  - 1224-8
AB  - This study was conducted on the basis of informed consent of subjects and was
      approved by the ethical review committee concerned. 527 pregnant women
      voluntarily participated in this project for the investigation of cardiac reserve
      mobilizing condition. Using the digital technique of heart sound signal
      processing, we measured the heart rate (HR), the ratio of the first heart sound
      to the second heart sound (S1/S2)and the ratio of diastolic to systolic duration 
      (D/S) during pregnancy. There was significant difference of HR and S1/S2 between 
      the group of non-pregnant (G1), the group of 28-36 pregnant weeks (G2), and the
      group of 37-42 pregnant weeks (G3) (HR, S1/S2: G1 vs G2, G1 vs G3: P < 0.01). HR 
      of the pregnant women increased with the increase of pregnant weeks. D/S
      decreased with the increase of pregnant weeks. There was significant difference
      of D/S between G1, G2, and G3 (G1 vs. G2: P < 0.01; G1 vs. G3: P < 0.01). There
      was also significant difference of D/S between G2 and G3 (G2 vs. G3: P < 0.05).
      Everybody in the non-pregnant women group was found to have D/S > or = 1.30;
      64.33% of pregnant women were found to have 1.00 < D/S < 1.30, whereas 3.05% of
      pregnant women were found to have D/S < 1.00. These data revealed that the heart 
      burden of the pregnant woman increased with the increase of pregnant weeks and
      the mobilization of cardiac reserve.
FAU - Zhang, Yinghong
AU  - Zhang Y
AD  - Obstetrics and Gynecology Department, First Affiliated Hospital of Chongqing
      Medical University, Chongqing 400016, China.
FAU - Shao, Yong
AU  - Shao Y
FAU - Xiao, Shouzhong
AU  - Xiao S
FAU - Guo, Xingming
AU  - Guo X
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
JT  - Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering =
      Shengwu yixue gongchengxue zazhi
JID - 9426398
SB  - IM
MH  - Adult
MH  - Female
MH  - Heart/*physiology
MH  - Heart Rate/physiology
MH  - Heart Sounds
MH  - Humans
MH  - Phonocardiography/methods
MH  - Pregnancy/*physiology
MH  - Pregnancy Trimester, Third/physiology
MH  - Signal Processing, Computer-Assisted
MH  - Young Adult
EDAT- 2011/03/08 06:00
MHDA- 2012/02/18 06:00
CRDT- 2011/03/08 06:00
PHST- 2011/03/08 06:00 [entrez]
PHST- 2011/03/08 06:00 [pubmed]
PHST- 2012/02/18 06:00 [medline]
PST - ppublish
SO  - Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2010 Dec;27(6):1224-8.


PMID- 21374845
OWN - NLM
STAT- MEDLINE
DCOM- 20160423
LR  - 20191112
IS  - 0714-9808 (Print)
IS  - 0714-9808 (Linking)
VI  - 29
IP  - 4
DP  - 2010 Dec
TI  - Ethics, health research, and Canada's aging population.
PG  - 577-85
FAU - Ries, Nola M
AU  - Ries NM
AD  - University of Alberta Health Law Institute, Edmonton, AB T6G 2H5.
      nries@law.ualberta.ca
LA  - eng
LA  - fre
PT  - Journal Article
PL  - Canada
TA  - Can J Aging
JT  - Canadian journal on aging = La revue canadienne du vieillissement
JID - 8708560
SB  - IM
MH  - *Aging
MH  - Canada
MH  - Humans
MH  - *Research
EDAT- 2011/03/05 06:00
MHDA- 2016/04/24 06:00
CRDT- 2011/03/05 06:00
PHST- 2011/03/05 06:00 [entrez]
PHST- 2011/03/05 06:00 [pubmed]
PHST- 2016/04/24 06:00 [medline]
AID - 10.1017/s0714980810000565 [doi]
PST - ppublish
SO  - Can J Aging. 2010 Dec;29(4):577-85. doi: 10.1017/s0714980810000565.


PMID- 21366000
OWN - NLM
STAT- MEDLINE
DCOM- 20110317
LR  - 20110303
IS  - 0712-6778 (Print)
IS  - 0712-6778 (Linking)
VI  - 28
IP  - 4
DP  - 2010 Dec
TI  - What do you mean you can't sterilize it? The reusable medical device matrix.
PG  - 6-11, 20-4
AB  - Health Canada recommends that hospitals should have procedures in place to ensure
      Reusable Medical Devices (RMD) are cleaned, disinfected and sterilized according 
      to the manufacturer's instructions. For the purpose of this paper, reusable
      medical devices will be referred to as RMDs and include all instrumentation and
      devices that the Central Processing Department (CPD) resterilizes for use in the 
      hospital. Patient safety in surgery begins in CPD. Manufacturer recommendations
      for the decontamination and sterilization of surgical instrumentation are of
      utmost importance to Operating Room (OR) and CPD staff. With recommendations that
      are unclear, nonspecific or unattainable there was a need to define what it means
      institutionally to meet standards and provide safe patient care while continuing 
      to support the advancement of surgical technology. The purpose of this paper is
      to describe the challenges faced by one multisite organization (The University
      Health Network) in managing the sterilization of surgical instrumentation. The
      development of The Guidance Matrix by the network's inter-professional Reusable
      Medical Device (RMD) Committee, will be discussed along with information about
      the elements of this tool and an illustration of how it is used. The key benefits
      of The Guidance Matrix, including how its use has facilitated transparent
      decision-making, communication and collaboration regarding sterilization issues
      across the sites, will be described. Sterilization processes in Central
      Processing Departments (CPD) include chemical indicators, dated load indicators, 
      and tamperproof locks and filters. The lack of an indicator of sterilization can 
      be a frustrating experience for an OR Nurse. But do we really understand the
      critical importance of all these indicators? The foundation of sterilizing
      reusable medical devices (RMDs) begins with proper processes, standards and
      subsequent scientific validation from the vendors. According to AORN, patient
      safety is vital and it begins with proper cleaning and processing of the surgical
      instruments. Surgical site infections can increase the length of stay and the
      cost of the patients' hospitalization, as well as increased risk, morbidity and
      even mortality. 1 Today's patients are far more informed than they were in the
      past. They can gather information from the internet as well as from television,
      radio, and print media. This knowledge empowers the patient to expect that their 
      healthcare providers are practicing due diligence. It is the ethical duty and
      responsibility of nurses to provide safe, competent care while protecting the
      rights of the patient and being accountable to the professional governing bodies.
      In other words, we are advocates for both our patients and the healthcare
      system.2 Using both new and innovative instruments in the OR was, in the past, as
      simple as a surgeon requesting an instrument, the perioperative nurse ordering
      the instrument and CPD processing it for use in the OR. That is no longer the
      case. With a wide range of more complex instrumentation and an increasing focus
      on sterilization strategies, healthcare facilities have had to adopt a more
      rigorous approach. There are many challenges in the world of sterile processing. 
      A common one, faced on a regular basis, is the provision of vague, inaccurate
      reprocessing recommendations from the medical device manufacturer. Canadian
      centres are not able to meet European standards for reprocessing. European
      cycles, often referred to as "Fractionated Steam Cycles", are different than the 
      pre-vacuum steam cycles run in Canada.
FAU - Stephens, Anne
AU  - Stephens A
AD  - University Health Network, Toronto General Hospital, USA. Anne.Stephens@uhn.on.ca
FAU - Assang, AnnMarie
AU  - Assang A
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Oper Room Nurs J
JT  - Canadian operating room nursing journal
JID - 8406632
MH  - Algorithms
MH  - Canada
MH  - Decision Trees
MH  - Equipment Contamination/*prevention & control/statistics & numerical data
MH  - *Equipment Reuse/standards/statistics & numerical data
MH  - Equipment Safety
MH  - *Equipment and Supplies/standards/supply & distribution
MH  - *Guidelines as Topic
MH  - Humans
MH  - Operating Room Nursing
MH  - Sterilization/*organization & administration
EDAT- 2011/03/04 06:00
MHDA- 2011/03/18 06:00
CRDT- 2011/03/04 06:00
PHST- 2011/03/04 06:00 [entrez]
PHST- 2011/03/04 06:00 [pubmed]
PHST- 2011/03/18 06:00 [medline]
PST - ppublish
SO  - Can Oper Room Nurs J. 2010 Dec;28(4):6-11, 20-4.


PMID- 21358924
OWN - NLM
STAT- MEDLINE
DCOM- 20110411
LR  - 20211020
IS  - 0008-5286 (Print)
IS  - 0008-5286 (Linking)
VI  - 51
IP  - 12
DP  - 2010 Dec
TI  - Veterinary medical ethics. An ethicist's commentary on misuse of presurgical lab 
      tests.
PG  - 1324
FAU - Rollin, Bernard E
AU  - Rollin BE
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Vet J
JT  - The Canadian veterinary journal = La revue veterinaire canadienne
JID - 0004653
SB  - IM
MH  - Animals
MH  - Canada
MH  - Diagnostic Techniques and Procedures/ethics/psychology/standards/*veterinary
MH  - Humans
MH  - Veterinarians/*ethics/*psychology
MH  - Veterinary Medicine/*ethics/methods/standards
PMC - PMC2978983
EDAT- 2011/03/02 06:00
MHDA- 2011/04/13 06:00
CRDT- 2011/03/02 06:00
PHST- 2011/03/02 06:00 [entrez]
PHST- 2011/03/02 06:00 [pubmed]
PHST- 2011/04/13 06:00 [medline]
PST - ppublish
SO  - Can Vet J. 2010 Dec;51(12):1324.


PMID- 21358897
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1918-1485 (Electronic)
IS  - 1205-7088 (Linking)
VI  - 15
IP  - 3
DP  - 2010 Mar
TI  - E-mail communication in paediatrics: Ethical and clinical considerations.
PG  - 163-8
AB  - E-mail has become a commonplace 'procedure' in medical practice because it is
      efficient and inexpensive. However, there are potential misuses and abuses of
      this form of written communication, with clinical and ethical implications.Common
      uses of e-mail in paediatics include general communication with colleagues in a
      professional setting; electronic formal consultation, in which patient
      confidentiality is paramount; electronic 'curb-side' consultation, which may be
      perceived as a formal consultation; electronic discussion groups, which lack peer
      review; communication with current patients or their parents, which should be
      limited to simple, nonurgent issues; and communication with individuals seeking
      medical advice who are not patients, which is generally ill-advised.The present
      practice point offers a few practical suggestions including e-mail etiquette,
      security measures to ensure confidentiality, development of an e-mail policy for 
      patients and parents, and separation of personal from professional e-mail.
FAU - Albersheim, S
AU  - Albersheim S
LA  - eng
LA  - fre
PT  - Journal Article
PL  - England
TA  - Paediatr Child Health
JT  - Paediatrics & child health
JID - 9815960
PMC - PMC2865955
OTO - NOTNLM
OT  - Communication
OT  - Confidentiality
OT  - E-mail
OT  - Medical consultation
OT  - Professionalism
EDAT- 2011/03/02 06:00
MHDA- 2011/03/02 06:01
CRDT- 2011/03/02 06:00
PHST- 2011/03/02 06:00 [entrez]
PHST- 2011/03/02 06:00 [pubmed]
PHST- 2011/03/02 06:01 [medline]
AID - 10.1093/pch/15.3.163 [doi]
PST - ppublish
SO  - Paediatr Child Health. 2010 Mar;15(3):163-8. doi: 10.1093/pch/15.3.163.


PMID- 21358861
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1918-1507 (Electronic)
IS  - 1195-2199 (Linking)
VI  - 18
IP  - 1
DP  - 2010 Spring
TI  - Contribution of the ulnar digits to grip strength.
PG  - e10-4
AB  - PURPOSE: To determine the contribution of ulnar digits to overall grip strength. 
      SUBJECTS: Fifty individuals (25 men and 25 women; 100 hands) with a mean age of
      35.6 years (range 19 to 62 years) were tested. Exclusion criteria included
      previous history of hand injuries, entrapment neuropathies and systemic diseases.
      METHODS: Ethics approval was granted before testing. A calibrated Jamar
      dynamometer (Lafayette Instrument Company, USA) was used to test subjects in
      three configurations: entire hand - index, middle, ring and little fingers;
      index, middle and ring fingers; and index and middle fingers. Little and ring
      fingers were excluded using generic hand-based finger splints. The order of
      testing was kept constant, and subjects were tested three times on each hand for 
      each configuration. The average of the three trials at each configuration was
      recorded. Subjects received 1 min of rest between each testing configuration. The
      data were analyzed using a 3x2 repeated measures ANOVA with hand dominance and
      configuration as the within-subject factors, followed by two independent sample t
      tests to compare flexor digitorum superficialis (FDS) independence and FDS
      nonindependence on right and left hand grip strength measurements in the index,
      middle, ring and little condition. RESULTS: Univariate results demonstrated that 
      grip strength was significantly predicted by the interaction between hand
      dominance and configuration, while the parsing of the interaction term
      demonstrated greater grip strength across all levels of configuration for the
      dominant and nondominant hand. There were no significant differences between FDS 
      independence and FDS nonindependence for either hand on grip strength.
      DISCUSSION: The results indicate a significant decrease in grip strength as ulnar
      fingers were excluded. Furthermore, exclusion of the little finger has differing 
      effects on the grip strength of the dominant and nondominant hands - the dominant
      hand had a greater loss of strength with the little finger excluded than the
      nondominant hand. CONCLUSIONS: The ulnar two digits play a significant role in
      overall grip strength of the entire hand. In the present study, exclusion of the 
      ulnar two digits resulted in a 34% to 67% decrease in grip strength, with a mean 
      decrease of 55%. Exclusion of the little finger from a functional grip pattern
      decreased the overall grip strength by 33%. Exclusion of the ring finger from a
      functional grip pattern decreased the overall grip strength by 21%. It is clear
      that limitation of one or both of the ulnar digits adversely affects the strength
      of the hand. In addition, there was no significant difference between grip
      strength of FDS-independent and FDS-nonindependent subjects for either hand.
FAU - Methot, Jennifer
AU  - Methot J
AD  - University of Western Ontario;
FAU - Chinchalkar, Shrikant J
AU  - Chinchalkar SJ
FAU - Richards, Robert S
AU  - Richards RS
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can J Plast Surg
JT  - The Canadian journal of plastic surgery = Journal canadien de chirurgie plastique
JID - 9434932
PMC - PMC2851460
OTO - NOTNLM
OT  - Grip strength
OT  - Testing
OT  - Ulnar digits
EDAT- 2011/03/02 06:00
MHDA- 2011/03/02 06:01
CRDT- 2011/03/02 06:00
PHST- 2011/03/02 06:00 [entrez]
PHST- 2011/03/02 06:00 [pubmed]
PHST- 2011/03/02 06:01 [medline]
PST - ppublish
SO  - Can J Plast Surg. 2010 Spring;18(1):e10-4.


PMID- 21355439
OWN - NLM
STAT- MEDLINE
DCOM- 20110421
LR  - 20161125
IS  - 1320-159X (Print)
IS  - 1320-159X (Linking)
VI  - 18
IP  - 2
DP  - 2010 Dec
TI  - The role of coronial autopsies in a context of decreasing hospital autopsies: an 
      investigation of the issues.
PG  - 402-12
AB  - This article scrutinises the argument that decreasing hospital autopsy rates are 
      outside the control of medical personnel, based as they are on families'
      unwillingness to consent to autopsy procedures, and that, as a consequence, the
      coronial autopsy is the appropriate alternative to the important medical and
      educational role of the autopsy It makes three points which are well supported by
      the research. First, that while hospital autopsy rates are decreasing, they have 
      been doing so for more than 60 years, and issues beyond the simple notion of
      consent, like funding formulae in hospitals, increased technology and fear of
      litigation by doctors are all playing their part in this decline. Secondly, the
      issue of consent has as much to do with families not being approached as with
      families declining to give consent. This is well supported by recent changes in
      hospital policy and procedures which include senior medical personnel and
      detailed consent forms, both of which have been linked to rising consent rates in
      recent years. Finally, the perception that coronial autopsies are beyond familial
      consent has been challenged recently by legislative changes in both Australia and
      the United States of America which allow objections based on religion and culture
      to be heard by coroners. For these reasons, it is argued that medical personnel
      need to focus on increasing hospital autopsy rates, while also addressing the
      complex ethical issues associated with conducting medical research within the
      context of the coronial autopsy.
FAU - Carpenter, Belinda
AU  - Carpenter B
AD  - School of Justice, Faculty of Law, Queensland University of Technology,
      Queensland, Australia. b.carpenter@qut.edu.au
FAU - Tait, Gordon
AU  - Tait G
FAU - Jonsson, Linda
AU  - Jonsson L
FAU - Peschl, Heiko
AU  - Peschl H
FAU - Naylor, Charles
AU  - Naylor C
FAU - Bermudez-Ortega, Aurora
AU  - Bermudez-Ortega A
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Law Med
JT  - Journal of law and medicine
JID - 9431853
SB  - IM
MH  - Australia
MH  - Autopsy/*legislation & jurisprudence/*statistics & numerical data
MH  - Coroners and Medical Examiners/*legislation & jurisprudence
MH  - Family
MH  - *Hospitals
MH  - Humans
MH  - Organizational Policy
MH  - Third-Party Consent/legislation & jurisprudence
MH  - United Kingdom
EDAT- 2011/03/02 06:00
MHDA- 2011/04/22 06:00
CRDT- 2011/03/02 06:00
PHST- 2011/03/02 06:00 [entrez]
PHST- 2011/03/02 06:00 [pubmed]
PHST- 2011/04/22 06:00 [medline]
PST - ppublish
SO  - J Law Med. 2010 Dec;18(2):402-12.


PMID- 21355437
OWN - NLM
STAT- MEDLINE
DCOM- 20110421
LR  - 20181201
IS  - 1320-159X (Print)
IS  - 1320-159X (Linking)
VI  - 18
IP  - 2
DP  - 2010 Dec
TI  - Law, autonomy and advance directives.
PG  - 366-89
AB  - The principle of autonomy underpins legal regulation of advance directives that
      refuse life-sustaining medical treatment. The primacy of autonomy in this domain 
      is recognised expressly in the case law, through judicial pronouncement, and
      implicitly in most Australian jurisdictions, through enactment into statute of
      the right to make an advance directive. This article seeks to justify autonomy as
      an appropriate principle for regulating advance directives and relies on three
      arguments: the necessity of autonomy in a liberal democracy; the primacy of
      autonomy in medical ethics discourse; and the uncontested importance of autonomy 
      in the law on contemporaneous refusal of medical treatment. This article also
      responds to key criticisms that autonomy is not an appropriate organising
      principle to underpin legal regulation of advance directives.
FAU - Willmott, Lindy
AU  - Willmott L
AD  - Health Law Research Program, Faculty of Law, Queensland University of Technology.
      l.willmott@qut.edu.au
FAU - White, Ben
AU  - White B
FAU - Mathews, Ben
AU  - Mathews B
LA  - eng
PT  - Journal Article
PT  - Legal Case
PL  - Australia
TA  - J Law Med
JT  - Journal of law and medicine
JID - 9431853
SB  - IM
MH  - Advance Directives/*legislation & jurisprudence
MH  - Australia
MH  - Humans
MH  - *Personal Autonomy
EDAT- 2011/03/02 06:00
MHDA- 2011/04/22 06:00
CRDT- 2011/03/02 06:00
PHST- 2011/03/02 06:00 [entrez]
PHST- 2011/03/02 06:00 [pubmed]
PHST- 2011/04/22 06:00 [medline]
PST - ppublish
SO  - J Law Med. 2010 Dec;18(2):366-89.


PMID- 21355433
OWN - NLM
STAT- MEDLINE
DCOM- 20110421
LR  - 20110301
IS  - 1320-159X (Print)
IS  - 1320-159X (Linking)
VI  - 18
IP  - 2
DP  - 2010 Dec
TI  - The strengths and limitations of empirical bioethics.
PG  - 316-9
AB  - The past two decades have been witness to an "empirical turn" in bioethics.
      Whereas once this field of study concerned itself purely with theoretical
      analysis of ethical issues emerging in the design and delivery of health care,
      increasingly bioethics has embraced a range of empirical research methods from
      the social sciences and humanities. The emergence of "empirical bioethics" has,
      however, been the subject of enormous debate, both in regard to its methods and
      its purpose. For the most part these criticisms fail to appreciate the
      assumptions that underpin empirical bioethics or misrepresent the claims that are
      made about its moral utility. This article provides a brief account of the
      assumptions, strengths and limitations of empirical bioethics.
FAU - Strong, K A
AU  - Strong KA
AD  - Centre for Values, Ethics and the Law in Medicine, University of Sydney,
      Australia. kimberly.strong@sydney.edu.au
FAU - Lipworth, W
AU  - Lipworth W
FAU - Kerridge, I
AU  - Kerridge I
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Law Med
JT  - Journal of law and medicine
JID - 9431853
SB  - IM
MH  - Bioethical Issues
MH  - Bioethics/*trends
MH  - *Empirical Research
MH  - Humans
EDAT- 2011/03/02 06:00
MHDA- 2011/04/22 06:00
CRDT- 2011/03/02 06:00
PHST- 2011/03/02 06:00 [entrez]
PHST- 2011/03/02 06:00 [pubmed]
PHST- 2011/04/22 06:00 [medline]
PST - ppublish
SO  - J Law Med. 2010 Dec;18(2):316-9.


PMID- 21355429
OWN - NLM
STAT- MEDLINE
DCOM- 20110421
LR  - 20110301
IS  - 1320-159X (Print)
IS  - 1320-159X (Linking)
VI  - 18
IP  - 2
DP  - 2010 Dec
TI  - What you see may not be what you get: beware of patients bearing gifts.
PG  - 268-74
AB  - The professional boundaries of practice for nurses and midwives are specifically 
      addressed in professional codes of ethics and conduct, employer policies and
      guidelines and more frequently in the professional literature. There are many
      forms in which boundary violations and boundary crossings may present or
      circumstances in which they may occur. This column considers a recent case
      (involving a bequest to a registered nurse under a will) which came before the
      Queensland Nursing Tribunal. The decisions of the tribunal, the District Court
      and the Court of Appeal provide practical guidance to nurses and midwives on the 
      importance of establishing and maintaining the professional boundaries essential 
      to the therapeutic relationship with their patients and clients.
FAU - Forrester, Kim
AU  - Forrester K
AD  - Supreme Court of Queensland. kforrester@qldbar.asn.au
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Law Med
JT  - Journal of law and medicine
JID - 9431853
SB  - IM
MH  - Australia
MH  - Gift Giving/*ethics
MH  - Humans
MH  - Nurse-Patient Relations/*ethics
MH  - Nurses/*legislation & jurisprudence
EDAT- 2011/03/02 06:00
MHDA- 2011/04/22 06:00
CRDT- 2011/03/02 06:00
PHST- 2011/03/02 06:00 [entrez]
PHST- 2011/03/02 06:00 [pubmed]
PHST- 2011/04/22 06:00 [medline]
PST - ppublish
SO  - J Law Med. 2010 Dec;18(2):268-74.


PMID- 21355428
OWN - NLM
STAT- MEDLINE
DCOM- 20110421
LR  - 20181201
IS  - 1320-159X (Print)
IS  - 1320-159X (Linking)
VI  - 18
IP  - 2
DP  - 2010 Dec
TI  - Vitamin C: ascerbic ethical discussions.
PG  - 263-7
AB  - The issue of a patient's rights to demand treatment has recently been raised by a
      dramatic case in which a patient made a remarkable recovery following the use of 
      an unconventional treatment that the hospital staff initially refused to
      administer. The normal position in such cases is that the relatives can take part
      in a clinical decision but the medical staff are bound to make it according to a 
      clinical assessment of the best interests of the patient. That assessment is only
      required to take into account what would be regarded as acceptable regimens of
      treatment for the patient's condition. There is no ethical or legal basis for the
      patient's relatives being able to demand any treatment that the clinical team do 
      not consider indicated nor to demand a highly unconventional treatment The case
      therefore poses a problem. When should we allow ourselves to be persuaded to step
      outside the bounds of accepted medical practice at the urging of relatives or
      patients? There are plausible arguments that a demonstration of efficacy in a
      particular patient or some reputable evidence of probability of efficacy would
      both be good enough grounds. In addition, one could argue that where the
      patient's predicted clinical course is terminal, then desperate measures of
      unproven efficacy can be tried in that the balance of harm and benefit cannot be 
      further worsened. The implication of the actual events in the case in question is
      that a certain humility in the light of the incompleteness of medical knowledge
      is always appropriate and an objective weighing of the facts of the case, free
      from prejudicial theoretical commitments, is needed in the face of medical
      uncertainty.
FAU - Gillett, Grant
AU  - Gillett G
AD  - Dunedin Hospital New Zealand. grant.gillett@stonebow.otago.ac.nz
LA  - eng
PT  - Journal Article
PT  - Legal Case
PL  - Australia
TA  - J Law Med
JT  - Journal of law and medicine
JID - 9431853
RN  - 0 (Vitamins)
RN  - PQ6CK8PD0R (Ascorbic Acid)
SB  - IM
MH  - Ascorbic Acid/*administration & dosage
MH  - Australia
MH  - Decision Making/*ethics
MH  - Humans
MH  - Life Support Care
MH  - Male
MH  - Middle Aged
MH  - Patient Rights/*legislation & jurisprudence
MH  - Vitamins/*administration & dosage
MH  - Withholding Treatment/legislation & jurisprudence
EDAT- 2011/03/02 06:00
MHDA- 2011/04/22 06:00
CRDT- 2011/03/02 06:00
PHST- 2011/03/02 06:00 [entrez]
PHST- 2011/03/02 06:00 [pubmed]
PHST- 2011/04/22 06:00 [medline]
PST - ppublish
SO  - J Law Med. 2010 Dec;18(2):263-7.


PMID- 21353967
OWN - NLM
STAT- MEDLINE
DCOM- 20110803
LR  - 20110228
IS  - 1776-2561 (Electronic)
IS  - 0761-8417 (Linking)
VI  - 67
IP  - 1
DP  - 2010 Feb
TI  - [Ethical contradictions in lung transplantation].
PG  - 3-4
LID - 10.1016/j.pneumo.2010.12.002 [doi]
AB  - Medical and scientific rationality often overlooked the importance of the
      symbolic dimension of personal and collective relationship to our body which
      organ transplantation cannot ignore. Hence the difficulty of the campaigns, with 
      a widening gulf between resuscitation maneuvers intended for the sole organ
      perfusion during the sampling in patients with heart stopped and fostering an
      attitude of a friendly support person. A well-doing medical discourse for the
      recipient cannot ignore a dialogue on the meaning of a "donation" of which
      counter-donation carries the same symbolic values.
CI  - Copyright (c) 2011. Published by Elsevier Masson SAS.
FAU - Sicard, D
AU  - Sicard D
AD  - Universite Paris Descartes, Paris, France. sicard.didier@gmail.com
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Contradictions ethiques en transplantation pulmonaire.
DEP - 20110128
PL  - France
TA  - Rev Pneumol Clin
JT  - Revue de pneumologie clinique
JID - 8406312
SB  - IM
MH  - Humans
MH  - Lung Transplantation/*ethics
EDAT- 2011/03/01 06:00
MHDA- 2011/08/04 06:00
CRDT- 2011/03/01 06:00
PHST- 2010/12/27 00:00 [received]
PHST- 2010/12/27 00:00 [accepted]
PHST- 2011/03/01 06:00 [entrez]
PHST- 2011/03/01 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
AID - S0761-8417(10)00182-3 [pii]
AID - 10.1016/j.pneumo.2010.12.002 [doi]
PST - ppublish
SO  - Rev Pneumol Clin. 2010 Feb;67(1):3-4. doi: 10.1016/j.pneumo.2010.12.002. Epub
      2011 Jan 28.


PMID- 21351693
OWN - NLM
STAT- MEDLINE
DCOM- 20110308
LR  - 20110227
IS  - 0033-2658 (Print)
IS  - 0033-2658 (Linking)
VI  - 112
IP  - 11
DP  - 2010
TI  - [Conflict of interest in clinical research--trends in guidelines for research
      ethics in Japan and other countries].
PG  - 1130-5
FAU - Tashiro, Munehiro
AU  - Tashiro M
LA  - jpn
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Seishin Shinkeigaku Zasshi
JT  - Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica
JID - 9801787
SB  - IM
MH  - Biomedical Research/*economics/*ethics/trends
MH  - Conflict of Interest/*economics
MH  - Disclosure/ethics
MH  - Drug Industry/*economics
MH  - *Guidelines as Topic
MH  - Humans
MH  - International Cooperation
MH  - Japan
MH  - United States
EDAT- 2011/03/01 06:00
MHDA- 2011/03/09 06:00
CRDT- 2011/03/01 06:00
PHST- 2011/03/01 06:00 [entrez]
PHST- 2011/03/01 06:00 [pubmed]
PHST- 2011/03/09 06:00 [medline]
PST - ppublish
SO  - Seishin Shinkeigaku Zasshi. 2010;112(11):1130-5.


PMID- 21350728
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20220317
IS  - 2229-5488 (Electronic)
IS  - 2229-3485 (Linking)
VI  - 1
IP  - 4
DP  - 2010 Oct
TI  - Training needs of clinical research associates.
PG  - 134-8
LID - 10.4103/2229-3485.71771 [doi]
AB  - Clinical research is a relatively new field in our country that has seen very
      rapid growth in the last few years. Availability of personnel appropriately
      trained to the specific requirements of the role they will perform in clinical
      research is critical for capacity expansion. Our study attempts to understand the
      specific areas of knowledge and skills that are important for the role of a
      clinical research associate. The survey was conducted among clinical research
      professionals from industry and academia who had more than five years of clinical
      research experience and held important decision making positions in clinical
      research (stakeholders). The survey questionnaire was designed as a matrix of
      various clinical research roles on the y-axis and six knowledge modules and eight
      skills on the x-axis. Respondents were asked to rate the importance of the
      knowledge /skills to the role of clinical research associates on a three point
      scale. In discussing results, a significant response was considered to be 50% or 
      greater positive response from the total group. The significant findings were
      that general, ethics and clinical trial execution modules were rated as critical 
      for the role of clinical research associate. Regulatory module was rated as
      important for the role. The other significant responses were that three of the
      sub-topics in the methodology module - framing a research proposal/protocol and
      experimental design, designing case report forms and EDCs and conducting PK
      studies - were rated as important and one sub topic in the data management and
      statistics module was rated as not important. All the skills except leadership
      skills were rated as critical for the role. The findings of our survey were in
      general on the lines of expectations of performance of the role. The general,
      ethics and clinical trial execution modules are critical knowledge areas for the 
      role of a clinical research associate. No clear trends emerged for some of the
      other modules. Leadership skills were not rated as critical to the role. This
      kind of a survey gives a good direction when training curriculum has to be
      designed for specific roles in clinical research. However, there is a need to
      expand the sample size to fine-tune the knowledge and skills areas.
FAU - Ajay, Samyuktha
AU  - Ajay S
AD  - Clinical Operations, Feasibility and Site ID, Quintiles India, 5th Floor, Leela
      Business Park, M. V. Road, Andheri (E), Mumbai - 400 059, India.
FAU - Bhatt, Arun
AU  - Bhatt A
LA  - eng
PT  - Journal Article
PL  - India
TA  - Perspect Clin Res
JT  - Perspectives in clinical research
JID - 101551517
PMC - PMC3043360
OTO - NOTNLM
OT  - Clinical research associates
OT  - clinical research training
OT  - modules
OT  - performance
OT  - roles
OT  - topics
EDAT- 2011/02/26 06:00
MHDA- 2011/02/26 06:01
CRDT- 2011/02/26 06:00
PHST- 2011/02/26 06:00 [entrez]
PHST- 2011/02/26 06:00 [pubmed]
PHST- 2011/02/26 06:01 [medline]
AID - 10.4103/2229-3485.71771 [doi]
PST - ppublish
SO  - Perspect Clin Res. 2010 Oct;1(4):134-8. doi: 10.4103/2229-3485.71771.


PMID- 21350726
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 2229-5488 (Electronic)
IS  - 2229-3485 (Linking)
VI  - 1
IP  - 4
DP  - 2010 Oct
TI  - Informed consent: Are we doing enough?
PG  - 124-7
LID - 10.4103/2229-3485.71769 [doi]
AB  - The process of informed consent is an ethical mandate for all clinical trials.
      The principles of ethics in research involving human beings decrees the conduct
      of a process where the prospective research subjects should be informed of all
      aspects of the research study and after complete comprehension of all the
      features involved, should express willingness to be a part of the study, and the 
      same should be duly documented. The consent should be fully informed and
      autonomous. However, with subject populations that are mostly medically naive and
      for whom the whole concept of clinical research and the umpteen terms and
      concepts associated with it are alien; the true essence of an "informed" and
      "autonomous" decision is largely lost. The consent process thus gets reduced to
      mainly a "narration-followed-by-signature" process. Over the last few years, this
      gap in principles and practices of ethics and consent has been acknowledged and
      innovative concepts and attempts are being fostered, to make the informed consent
      process more "ethical". The article discusses the loopholes associated with the
      informed consent process and the innovative concepts to make it more authentic.
FAU - Pranati
AU  - Pranati
AD  - Institute for One World Health, Liasion Field Office, Anand Vihar Building, 1st
      Floor, West Boring Canal Road, Patna-800001, Bihar, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Perspect Clin Res
JT  - Perspectives in clinical research
JID - 101551517
PMC - PMC3043361
OTO - NOTNLM
OT  - Autonomy
OT  - clinical trials
OT  - decision aids
OT  - informed consent
OT  - research ethics
EDAT- 2011/02/26 06:00
MHDA- 2011/02/26 06:01
CRDT- 2011/02/26 06:00
PHST- 2011/02/26 06:00 [entrez]
PHST- 2011/02/26 06:00 [pubmed]
PHST- 2011/02/26 06:01 [medline]
AID - 10.4103/2229-3485.71769 [doi]
PST - ppublish
SO  - Perspect Clin Res. 2010 Oct;1(4):124-7. doi: 10.4103/2229-3485.71769.


PMID- 21350628
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 0976-5018 (Electronic)
IS  - 0976-500X (Linking)
VI  - 1
IP  - 2
DP  - 2010 Jul
TI  - Committee on publication ethics.
PG  - 124-5
LID - 10.4103/0976-500X.72371 [doi]
FAU - Singh, Jatinder
AU  - Singh J
AD  - Section Editor, JPP.
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Pharmacol Pharmacother
JT  - Journal of pharmacology & pharmacotherapeutics
JID - 101552113
PMC - PMC3043328
EDAT- 2011/02/26 06:00
MHDA- 2011/02/26 06:01
CRDT- 2011/02/26 06:00
PHST- 2011/02/26 06:00 [entrez]
PHST- 2011/02/26 06:00 [pubmed]
PHST- 2011/02/26 06:01 [medline]
AID - 10.4103/0976-500X.72371 [doi]
PST - ppublish
SO  - J Pharmacol Pharmacother. 2010 Jul;1(2):124-5. doi: 10.4103/0976-500X.72371.


PMID- 21349047
OWN - NLM
STAT- MEDLINE
DCOM- 20110616
LR  - 20110225
IS  - 1756-5391 (Electronic)
IS  - 1756-5391 (Linking)
VI  - 3
IP  - 2
DP  - 2010 May
TI  - Conducting research in the aftermath of disasters: ethical considerations.
PG  - 65-75
LID - 10.1111/j.1756-5391.2010.01076.x [doi]
AB  - Disaster research focuses on the impact disasters have on people and social
      structures. Planning for and responding to disasters require evidence to guide
      decision-makers. The need for such evidence provides an ethical mandate for the
      conduct of sound disaster research. Disaster research ethics draws attention to
      ethical issues common to all research involving human subjects. However, disaster
      research involves a number of distinctive factors, including the degree of
      devastation affecting participants and the urgency often involved in initiating
      research projects. Such factors generate ethical issues not usually encountered
      with other types of research, and create tensions that must be taken into account
      in designing and conducting disaster research so that it attains the highest
      ethical standards. An overview of general research ethics issues is presented
      here in the context of disaster research. As with all research involving humans, 
      protection of participants and minimizing harm is the highest ethical priority.
      Other ethical issues include formal ethical approval, informed consent, balancing
      burdens and benefits, participant recruitment, coercion, the role of
      compensation, and conflicts of interest. Using examples from specific studies,
      some of the distinctive features of disaster research ethics are discussed. These
      include cross-cultural collaboration and communication, vulnerability of
      participants arising from the degree of devastation, avoiding exploitation of
      disaster victims, and protecting researchers. The article concludes with some of 
      the major challenges facing disaster research ethics and how they might be
      addressed.
CI  - (c) 2010 Blackwell Publishing Asia Pty Ltd and Chinese Cochrane Center, West
      China Hospital of Sichuan University.
FAU - O'Mathuna, Donal P
AU  - O'Mathuna DP
AD  - School of Nursing, Dublin City University, Glasnevin, Dublin, Ireland.
      donal.omathuna@dcu.ie
LA  - eng
PT  - Journal Article
DEP - 20100423
PL  - England
TA  - J Evid Based Med
JT  - Journal of evidence-based medicine
JID - 101497477
SB  - IM
MH  - Coercion
MH  - Developing Countries
MH  - *Disasters
MH  - *Ethics, Research
MH  - Evidence-Based Medicine
MH  - Humans
EDAT- 2011/02/26 06:00
MHDA- 2011/06/17 06:00
CRDT- 2011/02/26 06:00
PHST- 2011/02/26 06:00 [entrez]
PHST- 2011/02/26 06:00 [pubmed]
PHST- 2011/06/17 06:00 [medline]
AID - 10.1111/j.1756-5391.2010.01076.x [doi]
PST - ppublish
SO  - J Evid Based Med. 2010 May;3(2):65-75. doi: 10.1111/j.1756-5391.2010.01076.x.
      Epub 2010 Apr 23.


PMID- 21183963
OWN - NLM
STAT- MEDLINE
DCOM- 20110504
LR  - 20101224
IS  - 0211-6995 (Print)
IS  - 0211-6995 (Linking)
VI  - 30 Suppl 2
DP  - 2010
TI  - [Assessment and selection of kidney living donors].
PG  - 47-59
LID - 10.3265/Nefrologia.pre2010.Nov.10691 [doi]
AB  - Donor protection should always be taken account during the selection and
      assessment of a living donor. On these terms, the evaluation of a potential donor
      must include these issues: 1) The donor act is altruistic, consciousness and out 
      of coercion; 2) Life expectancy and quality of life of the recipient will improve
      after the living donor kidney transplantation; 3) The donor has normal renal
      function and the potential risk of developing nephropathy in the long term follow
      up is scarce (familiar nephropathies and other processes that may increase the
      potential risk for renal disease in the future, like severe hypertension,
      diabetes, etc must be ruled out). The glomerular filtrate should meet criteria
      for the normal function corresponding to age furthermore the absence of
      proteinuria and urine smear is normal; 4) The screening in the donor should
      contemplate those clinical situations or diseases non related to the kidney
      function but might elevate the surgical and/or anesthesia risk besides disease
      transmission to the recipient (as neoplasia or infections); 5) The surgical act
      is possible without technical difficulties and always performed after a negative 
      result of the crossmatch between donor and recipient. The living donor evaluation
      process will follow a different schedule based on each particular case and the
      center facilities. Any case, the mentioned process is divided in two parts: The
      first one contains an initial screening (using non invasive and low cost tests)
      that allows discarding contraindications for donation (in both donor and
      recipient). In a second phase the assessment of the donor varies with donor
      characteristics. However, a test for renal function is mandatory besides imaging 
      techniques (like angioTC), screening for transmissible diseases and a detailed
      evaluation for psychosocial aspects preferably made by professional. Moreover
      Spanish policy on living donation requires a report with information about the
      consent for donation developed by an independent board (ethics committee) besides
      the consent for donation given at the civil registry.
FAU - Gentil Govantes, Miguel Angel
AU  - Gentil Govantes MA
AD  - Unidad de Gestion Clinica de Urologia y Nefrologia, Hospital Universitario Virgen
      del Rocio, Sevilla. mgentil@cica.es
FAU - Pereira Palomo, Porfirio
AU  - Pereira Palomo P
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Practice Guideline
TT  - Estudio y seleccion del donante vivo de rinon.
PL  - Spain
TA  - Nefrologia
JT  - Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia
JID - 8301215
SB  - IM
MH  - Algorithms
MH  - Donor Selection/*methods
MH  - Humans
MH  - Kidney Diseases/diagnosis
MH  - Kidney Function Tests
MH  - *Kidney Transplantation
MH  - *Living Donors
EDAT- 2011/02/26 06:00
MHDA- 2011/05/05 06:00
CRDT- 2010/12/25 06:00
PHST- 2010/11/10 00:00 [accepted]
PHST- 2010/12/25 06:00 [entrez]
PHST- 2011/02/26 06:00 [pubmed]
PHST- 2011/05/05 06:00 [medline]
AID - 10.3265/Nefrologia.pre2010.Nov.10691 [doi]
PST - ppublish
SO  - Nefrologia. 2010;30 Suppl 2:47-59. doi: 10.3265/Nefrologia.pre2010.Nov.10691.


PMID- 21183962
OWN - NLM
STAT- MEDLINE
DCOM- 20110504
LR  - 20101224
IS  - 0211-6995 (Print)
IS  - 0211-6995 (Linking)
VI  - 30 Suppl 2
DP  - 2010
TI  - [Patient information: when and what].
PG  - 39-46
LID - 10.3265/Nefrologia.pre2010.Nov.10690 [doi]
AB  - The living donor kidney transplant should be considered a priority option
      providing better quality of life and survival for those needing renal replacement
      therapy. To increase their number, both nephrologists and patients, should be
      informed more and better, offering this option compared with LDKT alternatives
      (dialysis or kidney transplant from a deceased donor). The clinical nephrology
      consultations or specific pre-dialysis are the space where in stages 3 and 4 of
      renal failure should be started on LDKT informational approaches. Later, when
      seeking more detailed information and/or evaluation of potential donors, this
      could be provided at times and spaces specifically reserved for awareness
      professionals with the use of brochures or Internet addresses. Information should
      focus especially on the additional benefits of pre-emptive LDKT, the risks of
      nephrectomy and long term controls for the donor. Finally, donor, recipient and
      family should know that the donation will only be justified and may be accepted
      if the studies of risk/benefit for the donor and recipient have been faithfully
      evaluated according to the highest ethical standards.
FAU - Frutos, Miguel Angel
AU  - Frutos MA
AD  - Servico de Nefrologia, Hospital Regional Universitaro Carlos Haya, Malaga.
      mangel.frutos.sspa@juntadeandalucia.es
FAU - Cabello, Mercedes
AU  - Cabello M
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Practice Guideline
TT  - Informacion a pacientes: cuando y que informacion suministrar.
PL  - Spain
TA  - Nefrologia
JT  - Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia
JID - 8301215
SB  - IM
MH  - Humans
MH  - *Kidney Transplantation
MH  - *Living Donors
MH  - *Patient Education as Topic
MH  - Risk Assessment
EDAT- 2011/02/26 06:00
MHDA- 2011/05/05 06:00
CRDT- 2010/12/25 06:00
PHST- 2010/11/09 00:00 [accepted]
PHST- 2010/12/25 06:00 [entrez]
PHST- 2011/02/26 06:00 [pubmed]
PHST- 2011/05/05 06:00 [medline]
AID - 10.3265/Nefrologia.pre2010.Nov.10690 [doi]
PST - ppublish
SO  - Nefrologia. 2010;30 Suppl 2:39-46. doi: 10.3265/Nefrologia.pre2010.Nov.10690.


PMID- 21183959
OWN - NLM
STAT- MEDLINE
DCOM- 20110504
LR  - 20181201
IS  - 0211-6995 (Print)
IS  - 0211-6995 (Linking)
VI  - 30 Suppl 2
DP  - 2010
TI  - [Ethical aspects of living-donor kidney transplantation].
PG  - 14-22
LID - 10.3265/Nefrologia.pre2010.Nov.10687 [doi]
AB  - UNLABELLED: Living donor kidney transplantation is considered an established
      treatment for end-stage renal failure and is accepted in different transplant
      forums, nationally and internationally, while ensuring the safety of the
      donation, the information, the motivation and caring, the free consent and the
      absence profit. SAFETY: the living donor nephrectomy is not extent of risks so a 
      good assessment of the donor's health status and psychosocial situation must be
      performed to evaluate if the benefits to donor and recipient outweigh the risks
      assumed. Information and Consent: to be considered ethically acceptable, the
      donor must be able to give his free consent to the donation after understanding
      the information provided, accepting the risks and benefits of organ donation,
      knowing the treatment alternatives for the recipient and the long-term
      consequences of his decision The absence of profit: offering or receiving money
      for an organ or other human tissue violates the principles of justice and equity 
      and it is considered ethically and legally unacceptable MOTIVATION: it is
      important to make a good psychosocial assessment to identify whether the
      motivation is altruistic or not and, in other terms, to detect any kind of
      coercion (ex, in the family). Living donation must not be offered in desperate
      family situations so it is important to assess family relationships to rule out
      the absence of freedom in donor's choice.The Role of Health Care Ethics
      Committees: there exists a normative in our country that regulates living
      donation and establishes that the hospital ethics committees should participate
      in the process of living donation in all cases. Their job is to assess the
      process and develop a report on the donor free consent to donation. The
      responsible person of the living transplant program should provide the
      documentation necessary to the committee. An interview with the potential donor
      can be required in some cases.
FAU - Casares, Miguel
AU  - Casares M
AD  - Hospital Universitario de Getafe, Madrid. mcasares.hugf@salud.madrid.org
LA  - spa
PT  - Journal Article
PT  - Practice Guideline
TT  - Aspectos eticos de la donacion renal de vivo.
PL  - Spain
TA  - Nefrologia
JT  - Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia
JID - 8301215
SB  - IM
MH  - Algorithms
MH  - Humans
MH  - Informed Consent/ethics
MH  - Kidney Transplantation/*ethics
MH  - Living Donors/*ethics
MH  - Records
EDAT- 2011/02/26 06:00
MHDA- 2011/05/05 06:00
CRDT- 2010/12/25 06:00
PHST- 2010/11/09 00:00 [accepted]
PHST- 2010/12/25 06:00 [entrez]
PHST- 2011/02/26 06:00 [pubmed]
PHST- 2011/05/05 06:00 [medline]
AID - 10.3265/Nefrologia.pre2010.Nov.10687 [doi]
PST - ppublish
SO  - Nefrologia. 2010;30 Suppl 2:14-22. doi: 10.3265/Nefrologia.pre2010.Nov.10687.


PMID- 21342383
OWN - NLM
STAT- MEDLINE
DCOM- 20110610
LR  - 20110223
IS  - 1445-2197 (Electronic)
IS  - 1445-1433 (Linking)
VI  - 81
IP  - 3
DP  - 2011 Mar
TI  - A guide to multi-centre ethics for surgical research in Australia and New
      Zealand.
PG  - 132-6
LID - 10.1111/j.1445-2197.2010.05529.x [doi]
AB  - BACKGROUND: This paper describes existing inconsistencies as well as the
      disparate processes and logistics required when obtaining ethics approval in
      Australia and New Zealand in order to initiate a multi-centre bi-national
      surgical trial. METHODS: The endovascular aortic aneurysm repair trial is a large
      multi-centre trial that aims to obtain pre- and post-operative data from patients
      in hospitals across Australia and New Zealand. As the trial was research based,
      ethics applications were submitted to all hospitals where surgeons wished to be
      involved in the trial. RESULTS: Few ethics committees have embraced attempts to
      simplify the application process for multi-centre trials. There was limited
      mutual review between Human Research Ethics Committees necessitating the
      submission of multiple applications. Though the use of the National Ethics
      Application Form in ethical review is increasing, some Human Research Ethics
      Committees do not accept it in its entirety; many require site-specific
      applications or sections of the Common Application Form modules. CONCLUSIONS:
      Queensland, New South Wales and New Zealand were the easiest systems to prepare, 
      submit and lodge ethics applications because of their understanding and
      accommodation of reviewing multi-centred trials. The time, expense and complexity
      of obtaining ethics approval for multi-centre research projects are impediments
      to their establishment and reduce the time available for research. Australia is
      working to implement a system named the Harmonisation of Multi-centre Ethical
      Review to ease the process of obtaining multi-centre ethics clearance. Our
      experience suggests there will be some teething problems with implementation and 
      acceptance.
CI  - (c) 2010 The Authors. ANZ Journal of Surgery (c) 2010 Royal Australasian College 
      of Surgeons.
FAU - Boult, Maggi
AU  - Boult M
AD  - Department of Surgery, The University of Adelaide, Woodville South, South
      Australia, Australia.
FAU - Fitzpatrick, Kate
AU  - Fitzpatrick K
FAU - Maddern, Guy
AU  - Maddern G
FAU - Fitridge, Robert
AU  - Fitridge R
LA  - eng
PT  - Journal Article
DEP - 20101012
PL  - Australia
TA  - ANZ J Surg
JT  - ANZ journal of surgery
JID - 101086634
SB  - IM
MH  - Aortic Aneurysm/surgery
MH  - Australia
MH  - Endovascular Procedures/ethics
MH  - *Ethical Review
MH  - *Ethics Committees, Research
MH  - General Surgery/*ethics
MH  - Humans
MH  - International Cooperation
MH  - Multicenter Studies as Topic/*ethics
MH  - New Zealand
MH  - Research Design
EDAT- 2011/02/24 06:00
MHDA- 2011/06/11 06:00
CRDT- 2011/02/24 06:00
PHST- 2011/02/24 06:00 [entrez]
PHST- 2011/02/24 06:00 [pubmed]
PHST- 2011/06/11 06:00 [medline]
AID - 10.1111/j.1445-2197.2010.05529.x [doi]
PST - ppublish
SO  - ANZ J Surg. 2011 Mar;81(3):132-6. doi: 10.1111/j.1445-2197.2010.05529.x. Epub
      2010 Oct 12.


PMID- 21342382
OWN - NLM
STAT- MEDLINE
DCOM- 20110610
LR  - 20191210
IS  - 1445-2197 (Electronic)
IS  - 1445-1433 (Linking)
VI  - 81
IP  - 3
DP  - 2011 Mar
TI  - Ethical issues with the disclosure of surgical trial short-term data.
PG  - 125-31
LID - 10.1111/j.1445-2197.2010.05433.x [doi]
AB  - BACKGROUND: This paper describes the distinctions between major surgical and
      pharmaceutical trials and questions the application of a common ethical paradigm 
      to guide their conduct and reporting. METHODS: Surgical trials differ from other 
      trials in cumulative therapeutic effects, operator dependence, the clinical
      setting, interdependence of short- and long-term outcomes, and equipoise. A
      principal tenant of randomized controlled trial management is the maintenance of 
      interim data confidentiality. Its application to complete surgical short-term
      data is examined across a variety of common clinical trial circumstances that
      influence data integrity and the reliability of conclusions regarding the
      benefit-to-risk profile of experimental interventions. RESULTS: Complete
      perioperative results describe important treatment ends that cannot influence
      primary outcomes. These short-term results may inform patient consent, teaching
      and provide valuable procedural insights to surgeons outside trial precincts.
      CONCLUSION: Structured experimentation standards are necessary. But, the common
      paradigm applied across all clinical trials and the prohibition on short term
      data reporting may not serve the achievement of safe and effective advancements
      in surgery.
CI  - (c) 2010 The Authors. ANZ Journal of Surgery (c) 2010 Royal Australasian College 
      of Surgeons.
FAU - Allardyce, Randall A
AU  - Allardyce RA
AD  - Department of Surgery, University of Otago, Christchurch, New Zealand.
      randall.allardyce@otago.ac.nz
FAU - Bagshaw, Philip F
AU  - Bagshaw PF
FAU - Frampton, Christopher M
AU  - Frampton CM
FAU - Frizelle, Francis A
AU  - Frizelle FA
FAU - Hewett, Peter J
AU  - Hewett PJ
FAU - Rieger, Nicholas A
AU  - Rieger NA
FAU - Smith, J Shona
AU  - Smith JS
FAU - Solomon, Michael J
AU  - Solomon MJ
FAU - Stevenson, Andrew R L
AU  - Stevenson AR
LA  - eng
PT  - Journal Article
DEP - 20100816
PL  - Australia
TA  - ANZ J Surg
JT  - ANZ journal of surgery
JID - 101086634
SB  - IM
MH  - Bias
MH  - Clinical Trials Data Monitoring Committees
MH  - Confidentiality/ethics
MH  - Disclosure/*ethics
MH  - General Surgery/*ethics
MH  - Humans
MH  - Information Dissemination/ethics
MH  - Outcome Assessment, Health Care
MH  - Patient Access to Records/ethics
MH  - Randomized Controlled Trials as Topic/*ethics/standards
MH  - Research Design/standards
EDAT- 2011/02/24 06:00
MHDA- 2011/06/11 06:00
CRDT- 2011/02/24 06:00
PHST- 2011/02/24 06:00 [entrez]
PHST- 2011/02/24 06:00 [pubmed]
PHST- 2011/06/11 06:00 [medline]
AID - 10.1111/j.1445-2197.2010.05433.x [doi]
PST - ppublish
SO  - ANZ J Surg. 2011 Mar;81(3):125-31. doi: 10.1111/j.1445-2197.2010.05433.x. Epub
      2010 Aug 16.


PMID- 21340291
OWN - NLM
STAT- MEDLINE
DCOM- 20110406
LR  - 20190608
IS  - 0104-1169 (Print)
IS  - 0104-1169 (Linking)
VI  - 18
IP  - 6
DP  - 2010 Nov-Dec
TI  - Counseling regarding sexual and reproductive behavior: principles and practices
      of catholic priests.
PG  - 1237-45
LID - S0104-11692010000600026 [pii]
AB  - Considering and respecting religious beliefs and values is vital for delivering
      integral health care. This study describes the religious principles and guidance 
      provided by Catholic priests on sexuality and reproduction. The oral history
      method was used. Interviews were carried out between August 2007 and May 2008 and
      were analyzed in an inductive and interpretive manner to acquire a deep focus on 
      the theme. Thirteen Catholic priests from the city of Sao Paulo, SP, Brazil were 
      interviewed. Counseling provided by the priests has a traditional and
      conservative character and is based on principles of Catholic doctrine. Health
      education and promotion activities involving aspects related to sexuality and
      reproduction should be relevant and permeated with ethical considerations from
      the perspective of health care services' users, including religious perspectives.
FAU - Hoga, Luiza Akiko Komura
AU  - Hoga LA
AD  - Escola de Enfermagem, Universidade de Sao Paulo, SP, Brazil. kikatuca@usp.br
FAU - Tiburcio, Cristiane Alves
AU  - Tiburcio CA
FAU - Borges, Ana Luiza Vilela
AU  - Borges AL
FAU - Zoboli, Elma Lourdes Campos Pavone
AU  - Zoboli EL
FAU - Chavez-Alvarez, Rocio Elizabeth
AU  - Chavez-Alvarez RE
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - Rev Lat Am Enfermagem
JT  - Revista latino-americana de enfermagem
JID - 9420934
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brazil
MH  - *Catholicism
MH  - Humans
MH  - Middle Aged
MH  - *Reproductive Behavior
MH  - *Sex Counseling
EDAT- 2011/02/23 06:00
MHDA- 2011/04/07 06:00
CRDT- 2011/02/23 06:00
PHST- 2009/09/10 00:00 [received]
PHST- 2010/07/16 00:00 [accepted]
PHST- 2011/02/23 06:00 [entrez]
PHST- 2011/02/23 06:00 [pubmed]
PHST- 2011/04/07 06:00 [medline]
AID - S0104-11692010000600026 [pii]
AID - 10.1590/s0104-11692010000600026 [doi]
PST - ppublish
SO  - Rev Lat Am Enfermagem. 2010 Nov-Dec;18(6):1237-45. doi:
      10.1590/s0104-11692010000600026.


PMID- 21340287
OWN - NLM
STAT- MEDLINE
DCOM- 20110406
LR  - 20190608
IS  - 0104-1169 (Print)
IS  - 0104-1169 (Linking)
VI  - 18
IP  - 6
DP  - 2010 Nov-Dec
TI  - Knowledge on pressure ulcer prevention among nursing professionals.
PG  - 1203-11
LID - S0104-11692010000600022 [pii]
AB  - This study aimed to describe and to analyze knowledge on pressure ulcer
      prevention among nursing team members working in direct care to adult and elderly
      patients at a university hospital. A descriptive and exploratory research was
      carried out between January and March 2009, after approval by the Research Ethics
      Committee at the study institution. Data were collected through a validated
      questionnaire. Participants were 386 professionals, of whom 64.8% were nursing
      auxiliaries/technicians and 35.2% baccalaureate nurses (BSN). The mean percentage
      of correct answers on the knowledge test was 79.4% (SD=8.3%) for nurses and 73.6%
      (SD=9.8%) for nursing auxiliaries/technicians. Both professional categories
      display knowledge deficits in some areas related to the theme. The identification
      of deficient areas can guide strategic planning with a view to the dissemination 
      and adoption of prevention measures by the team.
FAU - Miyazaki, Margareth Yuri
AU  - Miyazaki MY
AD  - Universidade Paulista, SP, Brazil. myurimiyazaki@yahoo.com.br
FAU - Caliri, Maria Helena Larcher
AU  - Caliri MH
FAU - dos Santos, Claudia Benedita
AU  - dos Santos CB
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - Rev Lat Am Enfermagem
JT  - Revista latino-americana de enfermagem
JID - 9420934
MH  - Adult
MH  - *Clinical Competence
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Nursing Staff
MH  - Pressure Ulcer/*prevention & control
MH  - Surveys and Questionnaires
EDAT- 2011/02/23 06:00
MHDA- 2011/04/07 06:00
CRDT- 2011/02/23 06:00
PHST- 2009/08/20 00:00 [received]
PHST- 2010/07/19 00:00 [accepted]
PHST- 2011/02/23 06:00 [entrez]
PHST- 2011/02/23 06:00 [pubmed]
PHST- 2011/04/07 06:00 [medline]
AID - S0104-11692010000600022 [pii]
AID - 10.1590/s0104-11692010000600022 [doi]
PST - ppublish
SO  - Rev Lat Am Enfermagem. 2010 Nov-Dec;18(6):1203-11. doi:
      10.1590/s0104-11692010000600022.


PMID- 21340283
OWN - NLM
STAT- MEDLINE
DCOM- 20110406
LR  - 20220310
IS  - 0104-1169 (Print)
IS  - 0104-1169 (Linking)
VI  - 18
IP  - 6
DP  - 2010 Nov-Dec
TI  - The active search for respiratory symptomatics for the control of tuberculosis in
      the Potiguara Indigenous Scenario, Paraiba, Brazil.
PG  - 1169-76
LID - S0104-11692010000600018 [pii]
AB  - This study sought to analyze the actions of an active search for respiratory
      symptomatics (RSs) in the control of tuberculosis (TB) in the Potiguara Special
      Indigenous Sanitary District, Paraiba, Brazil, between May and June 2007. After
      approval by the Research Ethics Committee, 23 professionals were grouped,
      including physicians, nurses, nurse technicians and indigenous health agents. The
      focus group technique was used as an instrument for data collection, based on the
      discourse analysis technique. Weaknesses of an operational nature that became
      apparent, related to the organization of local health service for the
      implementation of routines for diagnosing TB: absence of a systematic routine for
      searching for RSs, difficulties in organizing the material for bacteriological
      examination, inadequate approach to patient during sputum collection and
      inadequate professional training. It is deemed necessary to improve the
      organization of services for early detection of TB cases in the local indigenous 
      scenario.
FAU - Nobrega, Rafaela Gerbasi
AU  - Nobrega RG
AD  - Centro Universitario de Joao Pessoa, PB, Brazil. rafaelagerbasi@yahoo.com.br
FAU - Nogueira, Jordana de Almeida
AU  - Nogueira Jde A
FAU - Netto, Antonio Ruffino
AU  - Netto AR
FAU - de Sa, Lenilde Duarte
AU  - de Sa LD
FAU - da Silva, Ana Tereza Medeiros Cavalcanti
AU  - da Silva AT
FAU - Villa, Tereza Cristina Scatena
AU  - Villa TC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Brazil
TA  - Rev Lat Am Enfermagem
JT  - Revista latino-americana de enfermagem
JID - 9420934
MH  - Brazil
MH  - Humans
MH  - *Indians, South American
MH  - Tuberculosis, Pulmonary/*diagnosis/*prevention & control
EDAT- 2011/02/23 06:00
MHDA- 2011/04/07 06:00
CRDT- 2011/02/23 06:00
PHST- 2010/09/12 00:00 [received]
PHST- 2010/07/16 00:00 [accepted]
PHST- 2011/02/23 06:00 [entrez]
PHST- 2011/02/23 06:00 [pubmed]
PHST- 2011/04/07 06:00 [medline]
AID - S0104-11692010000600018 [pii]
AID - 10.1590/s0104-11692010000600018 [doi]
PST - ppublish
SO  - Rev Lat Am Enfermagem. 2010 Nov-Dec;18(6):1169-76. doi:
      10.1590/s0104-11692010000600018.


PMID- 21338964
OWN - NLM
STAT- MEDLINE
DCOM- 20110713
LR  - 20110222
IS  - 1878-7452 (Electronic)
IS  - 1878-7452 (Linking)
VI  - 68
IP  - 2
DP  - 2011 Mar-Apr
TI  - Bacterial adherence to suture materials.
PG  - 101-4
LID - 10.1016/j.jsurg.2010.09.015 [doi]
AB  - BACKGROUND: Wound infections may be problematic for physicians. Whether a
      practitioner is managing complex penetrating trauma or a skin biopsy, there may
      be a need for suture closure. Suture material is an operator dependent variable
      and while little objective data exist to guide the choice of suture, it may play 
      a role in wound infection. This study evaluates bacterial adherence to commonly
      used suture materials with a bioluminescent in vitro model. METHODS: In all, 11
      strands of size 2-0 poliglecaprone suture (Monocryl; Ethicon, Inc, Somerville,
      New Jersey), polypropylene suture (Prolene; Ethicon, Inc), silk suture (Ethicon, 
      Inc), polyglycolic acid suture (Vicryl; Ethicon, Inc), and antimicrobial
      polyglycolic acid suture treated with triclosan (VicrylPlus; Ethicon, Inc) were
      immersed in a broth of Staphylococcus aureus engineered to emit photons. After
      biofilm formation, the suture strands were irrigated and imaged with a
      photon-capturing camera system yielding a total photon count that correlates with
      residual bacteria. RESULTS: The Vicryl suture had the highest counts and was
      statistically significant in bacterial adherence versus all other sutures. No
      other suture material was significantly different from any other. CONCLUSIONS:
      This study gives data to guide the selection of suture materials. Absorbable
      braided suture should not be used in closure of contaminated wounds or wounds at 
      risk for developing infection. The antibiotic impregnated absorbable braided
      suture was similar to the other suture types; however, it is at risk for
      reverting to the properties of its untreated counterpart over time. The bacterial
      adherence of suture materials should be taken into account by all practitioners
      when closing wounds or debriding infected wounds.
CI  - Copyright (c) 2011 Association of Program Directors in Surgery. Published by
      Elsevier Inc. All rights reserved.
FAU - Masini, Brendan D
AU  - Masini BD
AD  - Department of Orthopaedics and Rehabilitation, Brooke Army Medical Center, Ft Sam
      Houston, Texas 78234, USA. Brendan.Masini@amedd.army.mil
FAU - Stinner, Daniel J
AU  - Stinner DJ
FAU - Waterman, Scott M
AU  - Waterman SM
FAU - Wenke, Joseph C
AU  - Wenke JC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20101120
PL  - United States
TA  - J Surg Educ
JT  - Journal of surgical education
JID - 101303204
RN  - 0 (Culture Media)
RN  - 0 (Dioxanes)
RN  - 0 (Polyesters)
RN  - 0 (Polypropylenes)
RN  - 41706-81-4 (glycolide E-caprolactone copolymer)
SB  - IM
MH  - Analysis of Variance
MH  - *Bacterial Adhesion
MH  - Biofilms
MH  - Culture Media
MH  - Dioxanes/*pharmacology
MH  - Equipment Contamination
MH  - Humans
MH  - Materials Testing
MH  - Polyesters/*pharmacology
MH  - Polypropylenes/pharmacology
MH  - Primary Prevention/methods
MH  - Risk Assessment
MH  - Staphylococcus aureus/*physiology
MH  - Surgical Wound Infection/microbiology/prevention & control
MH  - Sutures/adverse effects/*microbiology
EDAT- 2011/02/23 06:00
MHDA- 2011/07/14 06:00
CRDT- 2011/02/23 06:00
PHST- 2010/05/24 00:00 [received]
PHST- 2010/09/09 00:00 [revised]
PHST- 2010/09/29 00:00 [accepted]
PHST- 2011/02/23 06:00 [entrez]
PHST- 2011/02/23 06:00 [pubmed]
PHST- 2011/07/14 06:00 [medline]
AID - S1931-7204(10)00278-3 [pii]
AID - 10.1016/j.jsurg.2010.09.015 [doi]
PST - ppublish
SO  - J Surg Educ. 2011 Mar-Apr;68(2):101-4. doi: 10.1016/j.jsurg.2010.09.015. Epub
      2010 Nov 20.


PMID- 21338030
OWN - NLM
STAT- MEDLINE
DCOM- 20110318
LR  - 20110221
IS  - 1054-6863 (Print)
IS  - 1054-6863 (Linking)
VI  - 20
IP  - 4
DP  - 2010 Dec
TI  - Examining the suitability of the principle of subsidiarity for bioethics.
PG  - 371-90
AB  - The political and social principle of subsidiarity can be useful as a general
      principle of bioethics. The principle states that only those decisions and tasks 
      that cannot be effectively decided upon or performed by a supported or subsidized
      lower level authority ought to be relegated to a more central or higher
      authority. The concept of subsidiarity has been embedded tacitly in Western
      political thought for two millennia, but it has been articulated expressly only
      in the twentieth century. The principle has unique strengths: it is the only
      principle that addresses the issue of locus of decision making; it is strongly
      linked to human dignity, democracy, and solidarity; and it can assist in reaching
      agreements on the common good. There are also potential drawbacks that need to be
      taken into account when developing rules and guidelines for the principle's
      application in bioethics. The principle is particularly helpful in public health 
      ethics, but it is also of use in the ethics of personal care and human research
      ethics.
FAU - Kotalik, Jaro
AU  - Kotalik J
AD  - Department of Philosophy, Lakehead University, Thunder Bay, Ontario.
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Kennedy Inst Ethics J
JT  - Kennedy Institute of Ethics journal
JID - 9109135
SB  - IM
MH  - *Bioethics
MH  - Decision Making/*ethics
MH  - Delivery of Health Care/*ethics
MH  - Democracy
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Politics
MH  - Public Health/*ethics
MH  - Social Justice
MH  - Social Responsibility
EDAT- 2011/02/23 06:00
MHDA- 2011/03/19 06:00
CRDT- 2011/02/23 06:00
PHST- 2011/02/23 06:00 [entrez]
PHST- 2011/02/23 06:00 [pubmed]
PHST- 2011/03/19 06:00 [medline]
PST - ppublish
SO  - Kennedy Inst Ethics J. 2010 Dec;20(4):371-90.


PMID- 21338029
OWN - NLM
STAT- MEDLINE
DCOM- 20110318
LR  - 20110221
IS  - 1054-6863 (Print)
IS  - 1054-6863 (Linking)
VI  - 20
IP  - 4
DP  - 2010 Dec
TI  - Does it matter whether investigators intend to benefit research subjects?
PG  - 353-70
AB  - There has been long-standing, albeit largely implicit, debate over whether
      investigator intentions are relevant to the ethical appropriateness of clinical
      research. Some commentators argue that whether investigators intend to collect
      generalizable knowledge or to benefit subjects is central to the ethics of
      clinical research. Others do not even mention investigator intentions when
      evaluating what makes clinical research ethical. To shed light on this debate,
      the present paper considers the reasons why investigator intentions might be
      ethically relevant. This analysis reveals that investigator intentions are
      related to, but distinct from three ethical requirements: whether subjects
      understand that they are contributing to a project to help others, whether the
      included interventions have an appropriate risk/benefit ratio, and whether
      subjects' interests are adequately protected. Provided these three requirements
      are satisfied, the ethical appropriateness of clinical research does not depend
      on what intentions investigators have in conducting it.
FAU - Wendler, David
AU  - Wendler D
AD  - Department of Bioethics, NIH Clinical Center, National Institutes of Health,
      Bethesda, MD, USA.
FAU - Abdoler, Emily
AU  - Abdoler E
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Kennedy Inst Ethics J
JT  - Kennedy Institute of Ethics journal
JID - 9109135
SB  - IM
MH  - *Beneficence
MH  - Comprehension
MH  - Ethics, Research
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - *Intention
MH  - Medical Oncology/ethics
MH  - Nontherapeutic Human Experimentation/ethics
MH  - Pediatrics/ethics
MH  - Research Personnel/*ethics
MH  - *Research Subjects
MH  - Researcher-Subject Relations/*ethics
MH  - Risk
MH  - Therapeutic Human Experimentation/ethics
EDAT- 2011/02/23 06:00
MHDA- 2011/03/19 06:00
CRDT- 2011/02/23 06:00
PHST- 2011/02/23 06:00 [entrez]
PHST- 2011/02/23 06:00 [pubmed]
PHST- 2011/03/19 06:00 [medline]
PST - ppublish
SO  - Kennedy Inst Ethics J. 2010 Dec;20(4):353-70.


PMID- 21338027
OWN - NLM
STAT- MEDLINE
DCOM- 20110318
LR  - 20110221
IS  - 1054-6863 (Print)
IS  - 1054-6863 (Linking)
VI  - 20
IP  - 4
DP  - 2010 Dec
TI  - Mandatory versus voluntary consent for newborn screening?
PG  - 299-328
AB  - Virtually every infant in the United States undergoes a heel stick within the
      first week of life to test for a variety of metabolic, endocrine, and
      hematological conditions as part of state-run universal newborn screening (NBS)
      programs. The history of this mandatory public health program is examined, as
      well as whether the policy was morally justifiable. Three changes in NBS practice
      necessitate a re-evaluation of the mandatory nature of NBS. First is the adoption
      of NBS for hemoglobinopathies in the 1980s that led to the identification of many
      sickle cell carriers and carriers of other hemoglobin variants. In all other
      contexts, carrier testing requires consent, and there is no moral rationale why
      NBS ought to be exceptional. Second is the application of tandem mass
      spectrometry (MS/MS) to NBS in the 1990s that led to the identification of many
      metabolic conditions and variants, some of which were not treatable and others of
      which had unknown clinical relevance. To the extent that the conditions do not
      need emergent diagnosis and treatment, there is less justification for mandatory 
      screening. Third, there is great interest in using residual blood spots for
      research, and the cornerstone of research ethics is the voluntary consent of the 
      participant (or his or her proxy). These three changes support revising mandatory
      NBS with a tiered consent process to best balance respect for parental autonomy
      and the promotion of children's health.
FAU - Ross, Lainie Friedman
AU  - Ross LF
AD  - Department of Pediatrics, MacLean Center for Clinical Medical Ethics, University 
      of Chicago, USA.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - Kennedy Inst Ethics J
JT  - Kennedy Institute of Ethics journal
JID - 9109135
SB  - IM
MH  - Ethics, Research
MH  - Hemoglobinopathies/diagnosis/history
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Infant, Newborn
MH  - Informed Consent/*ethics/history
MH  - Mandatory Testing/*ethics/history
MH  - Neonatal Screening/*ethics/history
MH  - *Parents
MH  - *Personal Autonomy
MH  - Phenylketonurias/diagnosis/history
MH  - Public Health/history
MH  - Tandem Mass Spectrometry
MH  - United States
EDAT- 2011/02/23 06:00
MHDA- 2011/03/19 06:00
CRDT- 2011/02/23 06:00
PHST- 2011/02/23 06:00 [entrez]
PHST- 2011/02/23 06:00 [pubmed]
PHST- 2011/03/19 06:00 [medline]
PST - ppublish
SO  - Kennedy Inst Ethics J. 2010 Dec;20(4):299-328.


PMID- 21337994
OWN - NLM
STAT- MEDLINE
DCOM- 20110310
LR  - 20110221
IS  - 1092-0811 (Print)
IS  - 1092-0811 (Linking)
VI  - 19
IP  - 6
DP  - 2010 Nov-Dec
TI  - Clinical ethics committees: organizational support for ethical practice.
PG  - 351-3
AB  - The tripartite functions of an ethics committee are case consultation,
      institutional policy review and development, and ethics education. Preparation
      before calling an ethics consultation is critical. In addition, serving on an
      ethics committee provides a personally and professionally rewarding experience
      because of the service performed for staff, patients, and families. This author
      encourages nurses to volunteer for this experience, as there is no better way to 
      understand the perplexing ethical problems in health care today. As nurses become
      more active on ethics committees, health care will transition from the
      traditional demand-initiated consult to a process that will emphasize the
      prevention of ethical conflicts by fostering the development of ethical practice 
      protocols or guidelines (Nelson et al., 2008).
FAU - Lachman, Vicki D
AU  - Lachman VD
AD  - Drexel University, Philadelphia, PA, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medsurg Nurs
JT  - Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses
JID - 9300545
MH  - Ethicists
MH  - Ethics Committees, Clinical/*organization & administration
MH  - Ethics Consultation/*organization & administration
MH  - Ethics, Clinical/education
MH  - Guidelines as Topic
MH  - Humans
MH  - *Nurse's Role
MH  - Organizational Objectives
MH  - Policy Making
MH  - Professional Competence
MH  - United States
EDAT- 2011/02/23 06:00
MHDA- 2011/03/11 06:00
CRDT- 2011/02/23 06:00
PHST- 2011/02/23 06:00 [entrez]
PHST- 2011/02/23 06:00 [pubmed]
PHST- 2011/03/11 06:00 [medline]
PST - ppublish
SO  - Medsurg Nurs. 2010 Nov-Dec;19(6):351-3.


PMID- 21337776
OWN - NLM
STAT- MEDLINE
DCOM- 20110324
LR  - 20220321
IS  - 0080-6234 (Print)
IS  - 0080-6234 (Linking)
VI  - 44
IP  - 4
DP  - 2010 Dec
TI  - [Reprocessing validation of angiographic cardiac catheters: an evaluation of the 
      functionality and integrity].
PG  - 947-55
AB  - The objective of this study was to validate the reprocessing of angiographic
      cardiac catheters regarding their characteristics of mechanical functionality and
      the molecular and micro-structural integrity of the polymeric chain.This is an
      experimental, applied, comparative and controlled study. A simulation set was
      built for a left coronary angiography in order to simulate mechanical and
      biological stress in the catheters. Traction tests were performed for the
      functionality and the integrity was tested through Infrared Spectrometry and
      Scanning Electronic Microscopy. The study evidenced a tendency to an increase in 
      rigidity at every increment of the reprocessing number (p < 0.05). The changes in
      the mechanical properties and molecular structures of the polymers were more
      evident as of the fifth reprocessing. Micrographies revealed an increase in
      rugosity as of the forth reprocessing. The results of this study may contribute
      to the elaboration of reprocessing protocols and a systematic surveillance of the
      reutilization of single use materials, not only due to their economical
      relevance, but especially from the ethical, legal, biological, functional and
      care point of view.
FAU - Lucas, Thabata Coaglio
AU  - Lucas TC
AD  - Pos-Graduacao em Engenharia Mecanica pela Universidade Federal de Minas Gerais,
      Belo Horizonte, MG, Brasil. thabataclucas@yahoo.com.br
FAU - Barbosa, Marcos Pinotti
AU  - Barbosa MP
FAU - de Oliveira, Adriana Cristina
AU  - de Oliveira AC
LA  - por
PT  - Comparative Study
PT  - Journal Article
PT  - Validation Study
TT  - Validacao do reprocessamento de cateteres cardiacos angiograficos: uma avaliacao 
      da funcionalidade e da integridade.
PL  - Brazil
TA  - Rev Esc Enferm USP
JT  - Revista da Escola de Enfermagem da U S P
JID - 0242726
MH  - Cardiac Catheterization/*instrumentation
MH  - Coronary Angiography/*instrumentation
MH  - Equipment Reuse/standards
MH  - Humans
EDAT- 2011/02/23 06:00
MHDA- 2011/03/25 06:00
CRDT- 2011/02/23 06:00
PHST- 2011/02/23 06:00 [entrez]
PHST- 2011/02/23 06:00 [pubmed]
PHST- 2011/03/25 06:00 [medline]
AID - S0080-62342010000400013 [pii]
AID - 10.1590/s0080-62342010000400013 [doi]
PST - ppublish
SO  - Rev Esc Enferm USP. 2010 Dec;44(4):947-55. doi: 10.1590/s0080-62342010000400013.


PMID- 21333925
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20110221
IS  - 1538-9375 (Electronic)
IS  - 1525-8610 (Linking)
VI  - 12
IP  - 3
DP  - 2011 Mar
TI  - Nutrition status among residents living in a veterans' long-term care facility in
      Western Canada: a pilot study.
PG  - 217-25
LID - 10.1016/j.jamda.2010.07.005 [doi]
AB  - OBJECTIVE: To examine nutrition status and to explore risk factors for
      malnutrition in an urban veterans' long-term care (LTC) facility in Western
      Canada to determine whether nutrition should be a higher priority for managers,
      physicians, and staff. DESIGN: A descriptive cross-sectional study design was
      used. SETTING: A LTC facility for Canadian veterans with a resident population of
      120 adults who are 65 years or older. PARTICIPANTS: The sample consisted of 55
      residents. Mean age was 86.5 years for the 50 men and 88.4 years for the 5 women.
      MEASUREMENTS: The Mini Nutritional Assessment (MNA) tool was used to examine the 
      nutrition status. Selected items and scales from the Minimum Data Set-Resident
      Assessment Instrument (MDS-RAI 2.0) were used to substitute for 10 MNA items.
      RESULTS: Six (11%) residents were assessed as well nourished. Thirty-two (58%)
      residents were considered at risk for malnutrition and 17 (31%) were rated
      malnourished. A linear regression model revealed that malnutrition was associated
      with depression (P = .002), instability in health (P = .005), and severity of
      dementia (P = .011). CONCLUSION: Most residents were found to be at risk or
      actually malnourished. Analyses of the results indicate that managers,
      physicians, and staff need to focus on residents with depression and dementia,
      and those whose health is unstable. Ethical considerations are important in
      choosing appropriate interventions because many LTC residents are at an
      end-of-life stage. Effective nutrition interventions (eg, adding resources to
      support residents during meals, changing environmental factors) exist but what
      has not been well investigated are the methods for translating such knowledge
      into practice.
CI  - Copyright (c) 2011 American Medical Directors Association. Published by Elsevier 
      Inc. All rights reserved.
FAU - Bostrom, Anne-Marie
AU  - Bostrom AM
AD  - Knowledge Utilization Studies Program, Faculty of Nursing, University of Alberta,
      Edmonton, Alberta, Canada. anne-marie.bostrom@ualberta.ca
FAU - Van Soest, Deanna
AU  - Van Soest D
FAU - Kolewaski, Betty
AU  - Kolewaski B
FAU - Milke, Doris L
AU  - Milke DL
FAU - Estabrooks, Carole A
AU  - Estabrooks CA
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101008
PL  - United States
TA  - J Am Med Dir Assoc
JT  - Journal of the American Medical Directors Association
JID - 100893243
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Analysis of Variance
MH  - Canada/epidemiology
MH  - Chi-Square Distribution
MH  - Cross-Sectional Studies
MH  - Dementia/epidemiology
MH  - Depression/epidemiology
MH  - Female
MH  - Geriatric Assessment
MH  - *Homes for the Aged
MH  - Humans
MH  - Linear Models
MH  - *Long-Term Care
MH  - Male
MH  - Malnutrition/*diagnosis/*epidemiology
MH  - Nutrition Assessment
MH  - *Nutritional Status
MH  - Pilot Projects
MH  - Risk Factors
MH  - *Veterans
EDAT- 2011/02/22 06:00
MHDA- 2011/06/29 06:00
CRDT- 2011/02/22 06:00
PHST- 2010/05/18 00:00 [received]
PHST- 2010/07/21 00:00 [revised]
PHST- 2010/07/26 00:00 [accepted]
PHST- 2011/02/22 06:00 [entrez]
PHST- 2011/02/22 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
AID - S1525-8610(10)00235-5 [pii]
AID - 10.1016/j.jamda.2010.07.005 [doi]
PST - ppublish
SO  - J Am Med Dir Assoc. 2011 Mar;12(3):217-25. doi: 10.1016/j.jamda.2010.07.005. Epub
      2010 Oct 8.


PMID- 21331383
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1687-9635 (Electronic)
VI  - 2010
DP  - 2010
TI  - Magnetic resonance imaging in a patient with a dual chamber pacemaker.
PG  - 292071
LID - 10.1155/2010/292071 [doi]
AB  - Having a pacemaker has been seen an absolute contraindication to having an MRI
      scan. This has become increasingly difficult in clinical practice as insertion of
      pacemakers and implantable cardiac defibrillators is at an all time high. Here we
      outline a case where a 71-year-old male patient with a permanent pacemaker needed
      to have an MRI scan to ascertain the aetiology of his condition and help guide
      further management. Given this clinical dilemma, an emergency clinical ethics
      consultation was arranged. As a result the patient underwent an MRI scan safely
      under controlled conditions with a consultant cardiologist and radiologist
      present. The results of the MRI scan were then able to tailor further treatment. 
      This case highlights that in certain conditions an MRI can be performed in
      patients with permanent pacemakers and outlines the role of clinical ethics
      committees in complex medical decision making.
FAU - Millar, Lynne Martina
AU  - Millar LM
AD  - Department of Cardiology, Royal Victoria Hospital, 274 Grosvenor Road, Belfast
      BT12 6BA, Northern Ireland.
FAU - Robinson, Andrew George
AU  - Robinson AG
FAU - O'Flaherty, Maurice Thomas
AU  - O'Flaherty MT
FAU - Eames, Niall
AU  - Eames N
FAU - Johnston, Nicola
AU  - Johnston N
FAU - Heyburn, Gary
AU  - Heyburn G
LA  - eng
PT  - Case Reports
DEP - 20110206
PL  - United States
TA  - Case Rep Med
JT  - Case reports in medicine
JID - 101512910
PMC - PMC3038614
EDAT- 2011/02/19 06:00
MHDA- 2011/02/19 06:01
CRDT- 2011/02/19 06:00
PHST- 2010/08/13 00:00 [received]
PHST- 2010/11/05 00:00 [revised]
PHST- 2010/12/03 00:00 [accepted]
PHST- 2011/02/19 06:00 [entrez]
PHST- 2011/02/19 06:00 [pubmed]
PHST- 2011/02/19 06:01 [medline]
AID - 10.1155/2010/292071 [doi]
PST - ppublish
SO  - Case Rep Med. 2010;2010:292071. doi: 10.1155/2010/292071. Epub 2011 Feb 6.


PMID- 21327173
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1998-4014 (Electronic)
IS  - 1998-4014 (Linking)
VI  - 8
IP  - 1
DP  - 2010 Jan
TI  - The noncompliant patient in psychiatry: the case for and against
      covert/surreptitious medication.
PG  - 96-121
LID - 10.4103/0973-1229.58822 [doi]
AB  - Nonadherence to treatment continues to be one of psychiatry's greatest
      challenges. To improve adherence and thus improve the care of patients,
      clinicians and patients' family members sometimes resort to hiding medication in 
      food or drink, a practice referred to as covert/ surreptitious medication. The
      practice of covert drug administration in food and beverages is well known in the
      treatment of psychiatrically ill world-wide but no prevalence rates exist. Covert
      medication may seem like a minor matter, but it touches on legal and ethical
      issues of a patient's competence, autonomy, and insight. Medicating patients
      without their knowledge is not justifiable solely as a shortcut for institutions 
      or families wishing to calm a troublesome patient and thus alleviate some of the 
      burdens of care giving. The paramount principle is ensuring the well-being of a
      patient who lacks the competence to give informed consent. Ethically,
      covert/surreptitious administration can be seen as a breach of trust by the
      doctor or by family members who administer the drugs. Covert medication
      contravenes contemporary ethical practice. Legally, treatment without consent is 
      permissible only where common law or statute provides such authority. The
      practice of covert administration of medication is not specifically covered in
      the mental health legislation in developing countries. Many of the current
      dilemmas in this area have come to public attention because of two important
      developments in medical ethics and the law - the increasing importance accorded
      to respect for autonomy and loss of the parens patriae jurisdiction of the courts
      [parens patriae means 'parent of the country'; it permitted a court to consent or
      refuse treatment on behalf of an 'incapacity', or alternatively to appoint a
      guardian with such powers].
FAU - Latha, K S
AU  - Latha KS
AD  - Associate Professor, Department of Psychiatry, KMC Hospital, Manipal University, 
      Manipal-576 104, Udupi, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Mens Sana Monogr
JT  - Mens sana monographs
JID - 101506580
PMC - PMC3031933
OTO - NOTNLM
OT  - Advance directives
OT  - Autonomy
OT  - Best Interests
OT  - Competency
OT  - Covert medication
OT  - Dignity
OT  - Informed Consent
OT  - Substitute Decision-Maker
OT  - Surreptitious prescribing
EDAT- 2011/02/18 06:00
MHDA- 2011/02/18 06:01
CRDT- 2011/02/18 06:00
PHST- 2009/06/15 00:00 [received]
PHST- 2009/12/22 00:00 [revised]
PHST- 2009/12/23 00:00 [accepted]
PHST- 2011/02/18 06:00 [entrez]
PHST- 2011/02/18 06:00 [pubmed]
PHST- 2011/02/18 06:01 [medline]
AID - 10.4103/0973-1229.58822 [doi]
PST - ppublish
SO  - Mens Sana Monogr. 2010 Jan;8(1):96-121. doi: 10.4103/0973-1229.58822.


PMID- 21327007
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 0016-9560 (Print)
IS  - 0016-9560 (Linking)
VI  - 44
IP  - 2
DP  - 2010 Jun
TI  - Is routine human papillomavirus vaccination an option for ghana?
PG  - 70-5
AB  - Cervical cancer remains an important public health problem in developing
      countries where over 80% of the global burden occurs annually but screening has
      been ineffective. In a polygamous country like Ghana with a high incidence of
      cervical cancer but no national screening program, the Human Papilloma Virus
      (HPV) vaccine presents a unique opportunity to reduce the burden of HPV infection
      and cervical cancer in Ghanaian women. The evidence so far indicates that the
      vaccines are safe and efficacious. Although routine HPV vaccination of girls
      raises several religious, political, socioeconomic and ethical challenges, the
      emphasis of this paper will be on addressing the ethical challenges using the
      principles of autonomy, beneficence, non-maleficence and justice as a framework. 
      Parental autonomy can be preserved with judicious exemptions for those who
      decline the vaccine on religious and philosophical grounds. This promotes public 
      health without trampling parental authority. Routine HPV vaccination confers
      several benefits to individuals and society by preventing HPV infection. Instead 
      of causing harm; it reduces harm by preventing the development of about 70% of
      cervical cancers and removing the negative physical and psychological impact of a
      cervical cancer diagnosis. It also has the potential to reduce the disparities in
      cervical cancer rates and its cost effectiveness will ensure considerable cost
      savings in terms of the money spent on diagnosis and treatment. Consequently, the
      HPV vaccine is an important public health landmark and achievement in women's
      health that must be heralded, especially in developing countries where the bulk
      of the disease and death occur.
FAU - Edwin, A K
AU  - Edwin AK
AD  - Department of Medicine, Korle-Bu Teaching Hospital, P. O. Box KB591, Korle-Bu,
      Accra, Ghana.
LA  - eng
PT  - Journal Article
PL  - Ghana
TA  - Ghana Med J
JT  - Ghana medical journal
JID - 0073210
PMC - PMC2994148
OTO - NOTNLM
OT  - Ghana
OT  - Human papilloma virus
OT  - pre-adolescent girls
OT  - vaccination
EDAT- 2011/02/18 06:00
MHDA- 2011/02/18 06:01
CRDT- 2011/02/18 06:00
PHST- 2011/02/18 06:00 [entrez]
PHST- 2011/02/18 06:00 [pubmed]
PHST- 2011/02/18 06:01 [medline]
AID - 10.4314/gmj.v44i2.68887 [doi]
PST - ppublish
SO  - Ghana Med J. 2010 Jun;44(2):70-5. doi: 10.4314/gmj.v44i2.68887.


PMID- 21322971
OWN - HMD
STAT- MEDLINE
DCOM- 20110331
LR  - 20191112
IS  - 0952-6951 (Print)
IS  - 0952-6951 (Linking)
VI  - 23
IP  - 5
DP  - 2010
TI  - Foucault's and Arendt's "insider view" of biopolitics: a critique of Agamben.
PG  - 113-30
AB  - This article revisits Arendt's and Foucault's converging accounts of modern
      (bio)politics and the entry of biological life into politics. Agamben's
      influential account of these ideas is rejected as a misrepresentation both
      because it de-historicizes biological/organic life and because it occludes the
      positivity of that life and thus the discursive appeal and performative force of 
      biopolitics. Through attention to the genealogy of Arendt's and Foucault's own
      ideas we will see that the major point of convergence in their thinking is their 
      insistence upon understanding biological thinking from the inside, in terms of
      its positivity. Agamben's assessment of modern politics is closer to Arendt's
      than it is to Foucault's and this marks a fascinating point of disagreement
      between Arendt and Foucault. Whereas Arendt sees the normalizing force of modern 
      society as being in total opposition to individuality, Foucault posits
      totalization and individuation as processes of normation, which casts a light
      upon the relative import they place upon politics and ethics.
FAU - Blencowe, Claire
AU  - Blencowe C
AD  - University of Bristol, UK.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - England
TA  - Hist Human Sci
JT  - History of the human sciences
JID - 100967737
MH  - *Biology/education/history
MH  - History, 20th Century
MH  - Human Characteristics
MH  - *Individuality
MH  - *Life
MH  - *Politics
MH  - Religion/history
MH  - Societies/history
MH  - *Thanatology/history
EDAT- 2011/02/18 06:00
MHDA- 2011/04/01 06:00
CRDT- 2011/02/18 06:00
PHST- 2011/02/18 06:00 [entrez]
PHST- 2011/02/18 06:00 [pubmed]
PHST- 2011/04/01 06:00 [medline]
AID - 10.1177/0952695110375762 [doi]
PST - ppublish
SO  - Hist Human Sci. 2010;23(5):113-30. doi: 10.1177/0952695110375762.


PMID- 21322408
OWN - NLM
STAT- MEDLINE
DCOM- 20110310
LR  - 20191112
IS  - 0745-5194 (Print)
IS  - 0745-5194 (Linking)
VI  - 24
IP  - 4
DP  - 2010 Dec
TI  - Tobacco talk: reflections on corporate power and the legal framing of
      consumption.
PG  - 500-21
AB  - This article examines how North Carolina tobacco farmers think about the moral
      ambiguities of tobacco business. Drawing on ethnographic research with tobacco
      farmers and archival research on the tobacco industry, I specify the core
      psychological defense mechanisms that tobacco companies have crafted for people
      associated with the industry. I also document local social, cultural, and
      economic factors in rural North Carolina that underpin ongoing rural dependence
      on tobacco despite the negativity that surrounds tobacco and structural
      adjustments. This article contributes to our knowledge about tobacco farmers and 
      tobacco farming communities, which is important for tobacco-control strategies. I
      reflect on ethical and economic paradoxes related to the rise of corporate social
      responsibility in the tobacco industry, where an official legal framing of
      consumption, focused on informed adult consumer autonomy and health education, is
      promoted to undermine more robust public health prevention efforts.
FAU - Benson, Peter
AU  - Benson P
AD  - Department of Anthropology, Washington University, St. Louis, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Anthropol Q
JT  - Medical anthropology quarterly
JID - 8405037
SB  - IM
MH  - *Agriculture
MH  - Humans
MH  - Public Health
MH  - Smoking
MH  - *Tobacco
MH  - *Tobacco Industry
EDAT- 2011/02/17 06:00
MHDA- 2011/03/11 06:00
CRDT- 2011/02/17 06:00
PHST- 2011/02/17 06:00 [entrez]
PHST- 2011/02/17 06:00 [pubmed]
PHST- 2011/03/11 06:00 [medline]
AID - 10.1111/j.1548-1387.2010.01120.x [doi]
PST - ppublish
SO  - Med Anthropol Q. 2010 Dec;24(4):500-21. doi: 10.1111/j.1548-1387.2010.01120.x.


PMID- 21322195
OWN - NLM
STAT- MEDLINE
DCOM- 20110304
LR  - 20181201
IS  - 0297-2964 (Print)
IS  - 0297-2964 (Linking)
IP  - 103
DP  - 2010 Dec
TI  - [Constipation in the hospital. Ethical reflection on its care by the nursing
      staff].
PG  - 67-77
AB  - The intestinal elimination of the hospitalized patients is a function
      insufficiently taken into account by the nursing staff from a preventive point of
      view. Nevertheless, numerous patients present transit disorders which are mostly 
      translated into a diagnosis of constipation requiring therapeutic prescriptions
      and sometimes even aggressive and expensive medical examinations. The objective
      of this work is to lead an ethical reflection on the care of intestinal
      elimination by the nursing staff. Through a questionnaire, we wish to answer 3
      questions: how come the nursing staff have difficulties taking care of the
      intestinal elimination of the hospitalized patients? What are the determiners
      which influence the care of the intestinal elimination by the nursing staff? Does
      training prepare the nursing staff to take care of the intestinal elimination of 
      the hospitalized patients? The questionnaire was distributed to doctors, male and
      female nurses, nursing auxiliaries and students in care of the sick working in
      medicine, surgery and intensive care of the same hospital. This survey allowed to
      question 130 persons among whom 36 doctors, 37 male and female nurses, 30 nursing
      auxiliaries and 27 students. We were able to confirm that the care of the
      intestinal elimination is insufficiently taken into account in a preventive way, 
      because 56 % of the people interviewed explain that the problem of intestinal
      elimination is not approached before the complaint of the patient Several
      determiners make that the nursing staff are not in a preventive approach. This
      care does not meet much interest, is experienced as devaluing, taboo and the
      relation nursing staff-patient is hindered because everyone has difficulties to
      speak about it. Institutional difficulties are also discussed, such as the lack
      of coordination of the nursing staff and the lack of time. Another point of this 
      survey shows that work experience is not an element which facilitates this care
      because the more the nursing staff have experience, the more they postpone this
      care and more the embarrassment is felt Finally, we were able to point out that
      the received training does not prepare the nursing staff to take care of this
      function. Indeed, 61% of the people interviewed explain that certain difficulties
      are inferred by the lack of social skills of the professionals, like the
      discomfort to speak about this particular need. This work thus allowed to lead
      this ethical reflection on the care of the intestinal elimination to understand
      its meaning.As Spinoza said: "One should not laugh, one should not despair, one
      should not curse, but one should understand".
FAU - Berger, Valerie
AU  - Berger V
AD  - CHU de Bordeaux.
FAU - Durand, Luc
AU  - Durand L
FAU - Grocq, Martine
AU  - Grocq M
LA  - fre
PT  - Journal Article
TT  - Elimination intestinale a l'hopital. Reflexion ethique sur sa prise en charge par
      les soignants.
PL  - France
TA  - Rech Soins Infirm
JT  - Recherche en soins infirmiers
JID - 9715370
MH  - *Attitude of Health Personnel
MH  - Clinical Competence
MH  - Communication Barriers
MH  - Constipation/*prevention & control
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - Humanism
MH  - Humans
MH  - Male
MH  - Medical Staff, Hospital/psychology
MH  - Nurse's Role/psychology
MH  - Nursing Assistants/psychology
MH  - Nursing Methodology Research
MH  - Nursing Staff, Hospital/education/*ethics/organization &
      administration/*psychology
MH  - Philosophy, Nursing
MH  - Self Efficacy
MH  - Shame
MH  - Students, Nursing/psychology
MH  - Surveys and Questionnaires
MH  - Thinking/*ethics
EDAT- 2011/02/17 06:00
MHDA- 2011/03/05 06:00
CRDT- 2011/02/17 06:00
PHST- 2011/02/17 06:00 [entrez]
PHST- 2011/02/17 06:00 [pubmed]
PHST- 2011/03/05 06:00 [medline]
PST - ppublish
SO  - Rech Soins Infirm. 2010 Dec;(103):67-77.


PMID- 21319672
OWN - NLM
STAT- MEDLINE
DCOM- 20110308
LR  - 20161125
IS  - 1474-9114 (Print)
IS  - 1474-9114 (Linking)
VI  - 20
IP  - 6
DP  - 2010
TI  - An evaluation of midwives' knowledge of formula feeding and their role in
      supporting mothers who formula feed their infants.
PG  - 192-7
AB  - OBJECTIVE: To explore midwives' knowledge of and support for formula feeding and 
      to identify barriers that may prevent midwives giving information to mothers who 
      formula feed their infants. METHOD: The study was designed in two phases using
      both qualitative and quantitative approaches. The total sample was 132 midwives. 
      Guidance on ethical approval was obtained from the National Research Ethics
      Service. RESULTS: The study identified that many midwives had a lack of knowledge
      of formula milks and that limited support is available for mothers who formula
      feed. This was compounded by a lack of unbiased literature for both mothers and
      midwives and a lack of understanding and/or a misinterpretation of policies.
      CONCLUSIONS: National guidelines support a policy of health professionals giving 
      mothers who formula feed the information they require. Mothers who have chosen to
      formula feed need this information to ensure their infants receive nourishment
      that is appropriate and is safely and correctly reconstituted. Recommendations
      are made for clinical practice that should have potential health benefits for
      infants who are formula fed while not undermining breast-feeding.
FAU - Battersby, Sue
AU  - Battersby S
AD  - sue.battersby@fsmail.net
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Fam Health Care
JT  - The journal of family health care
JID - 101142028
MH  - *Bottle Feeding
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Infant
MH  - *Infant Formula
MH  - Infant, Newborn
MH  - Information Seeking Behavior
MH  - *Midwifery
MH  - *Patient Education as Topic
MH  - Social Support
MH  - United Kingdom
EDAT- 2011/02/16 06:00
MHDA- 2011/03/09 06:00
CRDT- 2011/02/16 06:00
PHST- 2011/02/16 06:00 [entrez]
PHST- 2011/02/16 06:00 [pubmed]
PHST- 2011/03/09 06:00 [medline]
PST - ppublish
SO  - J Fam Health Care. 2010;20(6):192-7.


PMID- 21319664
OWN - NLM
STAT- MEDLINE
DCOM- 20110308
LR  - 20110215
IS  - 0025-7028 (Print)
IS  - 0025-7028 (Linking)
VI  - 99
IP  - 4
DP  - 2010
TI  - Physician, heal thyself? The ethics behind self-prescribing and curb-siding.
PG  - 24-5
FAU - McClain, Robert
AU  - McClain R
AD  - Mercer University School of Medicine, USA.
FAU - Elliott, Richard L
AU  - Elliott RL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Med Assoc Ga
JT  - Journal of the Medical Association of Georgia
JID - 7505620
SB  - IM
MH  - *Drug Prescriptions
MH  - *Ethics, Medical
MH  - Humans
EDAT- 2011/02/16 06:00
MHDA- 2011/03/09 06:00
CRDT- 2011/02/16 06:00
PHST- 2011/02/16 06:00 [entrez]
PHST- 2011/02/16 06:00 [pubmed]
PHST- 2011/03/09 06:00 [medline]
PST - ppublish
SO  - J Med Assoc Ga. 2010;99(4):24-5.


PMID- 21315284
OWN - NLM
STAT- MEDLINE
DCOM- 20110525
LR  - 20161125
IS  - 1872-9614 (Electronic)
IS  - 0969-8051 (Linking)
VI  - 38
IP  - 2
DP  - 2011 Feb
TI  - Biological studies in animal models using [99mTc](CO)3 recombinant annexin V as
      diagnostic agent of apoptotic processes.
PG  - 279-85
LID - 10.1016/j.nucmedbio.2010.08.007 [doi]
AB  - INTRODUCTION: There are many diseases associated with variations in the
      expression of apoptosis such as organ rejection after transplantation, myocardial
      ischemia or infarct and neurodegenerative diseases. For this reason, the early
      visualization of this process is relevant to set fast and effective therapeutic
      strategies. METHODS: The precursor was prepared according to the procedure
      reported by R. Alberto, R. Schibli, P. Schubiger, U. Abram, and T. Kaden
      [Reactions with the technetium and rhenium carbonyl complexes
      (NEt(4))[MX(3)(CO)(3)]. Synthesis and structure of Tc(CN-But)(3)(CO)(3)](NO(3))
      and (Net(4))[Tc(2)(mu-SCH(2)CH(2)OH)(3)(CO)(3)], Polyhedron 1996;15: 1079-89].
      Recombinant annexin V was incubated with [(99m)Tc](H(2)O)3(CO)(3)(+) solution,
      previously neutralized with buffer. Biodistribution studies were performed in
      8-week-old female Wistar rats. Animals were housed and treated in compliance with
      institutional guidelines related to animal experimentation. Work protocol was
      previously approved by the Animal Ethics Committee of the university. Two groups 
      of rats were defined. One was used as control and the other group was previously 
      injected with 150 mg/kg ip of cyclophosphamide to induce apoptosis. RESULTS: The 
      synthesis of carbonyl precursor achieved yields higher than 90%, and the
      radiolabeled protein was obtained with 92% of radiochemical purity and high
      stability in vitro. An important uptake in apoptotic tissues was confirmed by
      biodistributions, scintigraphic images and histological studies. CONCLUSIONS:
      Biodistribution studies revealed hepatobiliary elimination, high stability in
      vivo and important uptake in the reticuloendothelial system. In the pathologic
      model, higher uptake values correspond to the liver, spleen, lungs and femur.
      Histological studies confirmed the development of apoptosis at 8 and 24 h
      postinduction in the spleen and lymphocyte bulks in the peribronchial area.
      Scintigraphic images confirmed high uptake both the spleen and the lungs.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Teran, Mariella Adriana
AU  - Teran MA
AD  - Catedra de Radioquimica, Departamento Estrella Campos, Facultad de Quimica,
      Universidad de la Republica, P.O. 11800, Montevideo, Uruguay. mteran@fq.edu.uy
FAU - Martinez, Elena
AU  - Martinez E
FAU - Reyes, Ana L
AU  - Reyes AL
FAU - Paolino, Andrea
AU  - Paolino A
FAU - Vital, Marcelo
AU  - Vital M
FAU - Esperon, Patricia
AU  - Esperon P
FAU - Pacheco, Jose P
AU  - Pacheco JP
FAU - Savio, Eduardo
AU  - Savio E
LA  - eng
PT  - Journal Article
DEP - 20101105
PL  - United States
TA  - Nucl Med Biol
JT  - Nuclear medicine and biology
JID - 9304420
RN  - 0 (Annexin A5)
RN  - 0 (Organotechnetium Compounds)
RN  - 0 (Recombinant Proteins)
SB  - IM
MH  - Animals
MH  - *Annexin A5/chemistry/pharmacokinetics
MH  - *Apoptosis
MH  - Chemical Phenomena
MH  - Drug Stability
MH  - Female
MH  - Humans
MH  - Models, Animal
MH  - *Organotechnetium Compounds
MH  - Rats
MH  - Rats, Wistar
MH  - *Recombinant Proteins/chemistry/pharmacokinetics
EDAT- 2011/02/15 06:00
MHDA- 2011/05/26 06:00
CRDT- 2011/02/15 06:00
PHST- 2009/07/10 00:00 [received]
PHST- 2010/06/15 00:00 [revised]
PHST- 2010/08/24 00:00 [accepted]
PHST- 2011/02/15 06:00 [entrez]
PHST- 2011/02/15 06:00 [pubmed]
PHST- 2011/05/26 06:00 [medline]
AID - S0969-8051(10)00414-2 [pii]
AID - 10.1016/j.nucmedbio.2010.08.007 [doi]
PST - ppublish
SO  - Nucl Med Biol. 2011 Feb;38(2):279-85. doi: 10.1016/j.nucmedbio.2010.08.007. Epub 
      2010 Nov 5.


PMID- 21314050
OWN - NLM
STAT- MEDLINE
DCOM- 20110324
LR  - 20181201
IS  - 0002-7979 (Print)
IS  - 0002-7979 (Linking)
VI  - 77
IP  - 3
DP  - 2010 Fall
TI  - Maximizing beneficence and autonomy. Ethical support for the use of
      nonpharmacological methods for managing dental anxiety.
PG  - 26-34
AB  - This article examines advantages associated with nonpharmacological behavioral
      management techniques and suggests that there are benefits to their use (such as 
      achieving a more lasting solution to the problem of dental anxiety) that are not 
      realized with medication-based interventions. Analyses that use Kantian and
      existential viewpoints for exploring the use of medication versus behavioral
      interventions for managing life problems yield parallel conclusions: there are
      advantages gained by using behavioral interventions that are not always
      associated with medication-based interventions. These analyses, taken together
      with an understanding of the psychology of dental anxiety management, suggest
      that using nonpharmacological techniques for the management of dental anxiety can
      maximize adherence to the ethical principles of beneficence and patient autonomy.
      The authors discuss the barriers that make nonpharmacological interventions for
      anxiety management difficult for dentists to routinely use, and suggest that
      additional training in these methods and increased collaboration with mental
      health professionals are needed for dentists.
FAU - Donate-Bartfield, Evelyn
AU  - Donate-Bartfield E
AD  - Marquette University School of Dentistry, USA. evelyn.bartfield@marquette.edu
FAU - Spellecy, Ryan
AU  - Spellecy R
FAU - Shane, Nicholas J
AU  - Shane NJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Coll Dent
JT  - The Journal of the American College of Dentists
JID - 7503057
RN  - 0 (Anti-Anxiety Agents)
SB  - IM
MH  - Adaptation, Psychological
MH  - Anti-Anxiety Agents/therapeutic use
MH  - Attitude of Health Personnel
MH  - Attitude to Health
MH  - Behavior Control
MH  - *Behavior Therapy
MH  - *Beneficence
MH  - Clinical Competence
MH  - Cognitive Behavioral Therapy
MH  - Communication
MH  - Contraindications
MH  - Dental Anxiety/*prevention & control/psychology
MH  - Dental Care/*psychology
MH  - Dentist-Patient Relations/*ethics
MH  - Existentialism
MH  - Humans
MH  - Mind-Body Therapies
MH  - Pain/psychology
MH  - Patient Acceptance of Health Care
MH  - *Personal Autonomy
MH  - Psychoanalytic Theory
MH  - Referral and Consultation
MH  - Self Efficacy
MH  - Time Factors
EDAT- 2011/02/15 06:00
MHDA- 2011/03/25 06:00
CRDT- 2011/02/15 06:00
PHST- 2011/02/15 06:00 [entrez]
PHST- 2011/02/15 06:00 [pubmed]
PHST- 2011/03/25 06:00 [medline]
PST - ppublish
SO  - J Am Coll Dent. 2010 Fall;77(3):26-34.


PMID- 21314045
OWN - NLM
STAT- MEDLINE
DCOM- 20110324
LR  - 20110214
IS  - 0002-7979 (Print)
IS  - 0002-7979 (Linking)
VI  - 77
IP  - 3
DP  - 2010 Fall
TI  - New leaders in dentistry: dental students.
PG  - 10-3
AB  - Leadership opportunities for dental students have opened dramatically in recent
      decades because of the humanistic approach to education that shares
      responsibility for learning between students and faculty and that values mutual
      respect. Technology has also had an effect because it creates instant access and 
      global communities. This new student leadership is most apparent in the American 
      Student Dental Association (ASDA), which recently developed a White Paper on
      ethics, assisted in the establishment of Student Professionalism and Ethics Clubs
      at schools, and is developing a policy on unsupervised dental care. Students are 
      also demonstrating leadership in research; in dual degrees that enhance teaching 
      and policy; and in community service and outreach.
FAU - Hammer, Dan
AU  - Hammer D
AD  - University of the Pacific, Arthur A. Dugoni School of Dentistry, USA.
      d_hammer@upacific.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Coll Dent
JT  - The Journal of the American College of Dentists
JID - 7503057
SB  - IM
MH  - Community-Institutional Relations
MH  - Computer Communication Networks
MH  - Dental Care
MH  - Dental Research
MH  - Dentist-Patient Relations
MH  - *Dentistry
MH  - Education, Dental
MH  - Ethics, Dental
MH  - Faculty, Dental
MH  - Health Policy
MH  - Humans
MH  - Interpersonal Relations
MH  - *Leadership
MH  - Learning
MH  - Preceptorship
MH  - Professional Competence
MH  - Societies
MH  - *Students, Dental
MH  - Teaching
MH  - United States
EDAT- 2011/02/15 06:00
MHDA- 2011/03/25 06:00
CRDT- 2011/02/15 06:00
PHST- 2011/02/15 06:00 [entrez]
PHST- 2011/02/15 06:00 [pubmed]
PHST- 2011/03/25 06:00 [medline]
PST - ppublish
SO  - J Am Coll Dent. 2010 Fall;77(3):10-3.


PMID- 21313924
OWN - NLM
STAT- MEDLINE
DCOM- 20110329
LR  - 20211020
IS  - 0022-1058 (Print)
IS  - 0022-1058 (Linking)
VI  - 42
IP  - 4
DP  - 2010 Dec
TI  - Extracorporeal life support for pandemic influenza: the role of extracorporeal
      membrane oxygenation in pandemic management.
PG  - 268-80
AB  - The recent global threat of a severe pandemic influenza outbreak has suggested
      that extracorporeal life support will begin to play an evolving role in the care 
      of critically ill influenza stricken patients. The highly communicable attributes
      of influenza could result in widespread infection and an associated increased
      need for advanced life support. Supply and demand equilibrium may be abruptly
      disrupted, and ethical decisions regarding the allocation of life saving
      resources will inevitably need to be made. Protocol oriented planning, research
      analysis, and advanced technologies are critical factors in averting catastrophe.
      This review article details the epidemiology, diagnostic techniques, and
      interventions for the influenza A virus, including H1N1.
FAU - DeLaney, Ed
AU  - DeLaney E
AD  - Lenox Hill Hospital, New York, New York 10021, USA. e26delaney@yahoo.com
FAU - Smith, Michael J
AU  - Smith MJ
FAU - Harvey, Brian T
AU  - Harvey BT
FAU - Pelletier, Keith J
AU  - Pelletier KJ
FAU - Aquino, Michael P
AU  - Aquino MP
FAU - Stone, Justin M
AU  - Stone JM
FAU - Jean-Baptiste, Gerald C
AU  - Jean-Baptiste GC
FAU - Johnson, Julie H
AU  - Johnson JH
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Extra Corpor Technol
JT  - The journal of extra-corporeal technology
JID - 0267637
EIN - J Extra Corpor Technol. 2011 Mar;43(1):41
MH  - Extracorporeal Membrane Oxygenation/instrumentation/*methods/*mortality
MH  - Humans
MH  - *Influenza A Virus, H1N1 Subtype
MH  - Influenza, Human/*mortality/*rehabilitation
MH  - Pandemics/*prevention & control/*statistics & numerical data
PMC - PMC4680015
EDAT- 2011/02/15 06:00
MHDA- 2011/03/30 06:00
CRDT- 2011/02/15 06:00
PHST- 2011/02/15 06:00 [entrez]
PHST- 2011/02/15 06:00 [pubmed]
PHST- 2011/03/30 06:00 [medline]
PST - ppublish
SO  - J Extra Corpor Technol. 2010 Dec;42(4):268-80.


PMID- 21313868
OWN - NLM
STAT- MEDLINE
DCOM- 20110310
LR  - 20151119
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 21
IP  - 4
DP  - 2010 Winter
TI  - Medical school oath-taking: the moral controversy.
PG  - 335-45
AB  - Professions typically formulate codes of ethics. Medical students are exposed to 
      various codes and often are expected to recite some code or oath at their
      graduation. This article reports the findings of a study of one large medical
      class, asked upon entry to medical school and again at the beginning of their
      fourth term, which of 13 specified professional, religious, and secular codes of 
      ethics they would turn to for moral guidance in their practice of medicine. The
      study finds great diversity in the students' choices and no clear pattern of
      change by their fourth term. Very few students chose the oath they would be asked
      to recite at their graduation. The article probes the problems this creates for
      school administrators and professors as well as students. It asks the
      implications for professional oath-taking at graduation and in the practice of
      the profession.
FAU - Veatch, Robert M
AU  - Veatch RM
AD  - Kennedy Institute of Ethics, Georgetown University, Washington, DC, USA.
      veatchr@georgetown.edu
FAU - Macpherson, Cheryl C
AU  - Macpherson CC
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
MH  - *Codes of Ethics
MH  - Education, Medical/*standards
MH  - *Ethics, Clinical
MH  - *Ethics, Medical
MH  - Grenada
MH  - Hippocratic Oath
MH  - Humans
MH  - *Religion and Medicine
MH  - Schools, Medical/statistics & numerical data
MH  - Students, Medical/psychology/*statistics & numerical data
MH  - Surveys and Questionnaires
EDAT- 2011/02/15 06:00
MHDA- 2011/03/11 06:00
CRDT- 2011/02/15 06:00
PHST- 2011/02/15 06:00 [entrez]
PHST- 2011/02/15 06:00 [pubmed]
PHST- 2011/03/11 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2010 Winter;21(4):335-45.


PMID- 21313866
OWN - NLM
STAT- MEDLINE
DCOM- 20110310
LR  - 20141120
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 21
IP  - 4
DP  - 2010 Winter
TI  - Taking seriously the "what then?" question: an ethical framework for the
      responsible management of medical disasters.
PG  - 321-7
AB  - When healthcare resources become overwhelmed in medical disasters, as they
      inevitably will, we have to ask, in an unflinching fashion, the question: "What
      then?" or more precisely, "What should we do when we run out of resources?" In a 
      mass casualty event worthy of the designation, we will indeed run out of
      resources, perhaps quite quickly. This article provides an ethical framework for 
      the responsible management of medical disasters in which the "What then?"
      question must be asked. The framework begins with a critique of existing guidance
      from professional associations of physicians and then argues for an alternative
      approach that qualifies the obligation to preserve life, takes seriously the
      ethical challenges of overwhelmed healthcare resources, and countenances
      physician-assisted suicide as a last resort.
FAU - McCullough, Laurence B
AU  - McCullough LB
AD  - Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston,
      Texas, USA. mccullou@bcm.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
MH  - Disasters
MH  - Global Health
MH  - Health Care Rationing/*ethics
MH  - Health Resources/*supply & distribution
MH  - Health Services Needs and Demand/*ethics
MH  - Humans
MH  - *Mass Casualty Incidents
MH  - Practice Guidelines as Topic
MH  - Societies, Medical
MH  - Suicide, Assisted/*ethics
MH  - Triage/*ethics
MH  - United States
EDAT- 2011/02/15 06:00
MHDA- 2011/03/11 06:00
CRDT- 2011/02/15 06:00
PHST- 2011/02/15 06:00 [entrez]
PHST- 2011/02/15 06:00 [pubmed]
PHST- 2011/03/11 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2010 Winter;21(4):321-7.


PMID- 21313863
OWN - NLM
STAT- MEDLINE
DCOM- 20110310
LR  - 20110214
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 21
IP  - 4
DP  - 2010 Winter
TI  - Sufficiency of care in disasters: ventilation, ventilator triage, and the
      misconception of guideline-driven treatment.
PG  - 294-307
AB  - This essay examines the management of ventilatory failure in disaster settings
      where clinical needs overwhelm available resources. An ethically defensible
      approach in such settings will adopt a "sufficiency of care" perspective that is:
      (1) adaptive, (2) resource-driven, and (3) responsive to the values of
      populations being served. Detailed, generic, antecedently written guidelines for 
      "ventilator triage" or other management issues typically are of limited value,
      and may even impede ethical disaster response if they result in rescuers'
      clumsily interpreting events through the lens of the guideline, rather than
      customizing tactics to the actual context. Especially concerning is the tendency 
      of some expert planners to mistakenly assume that medical treatment of
      respiratory failure: (1) always requires full-feature mechanical ventilators, (2)
      will always occur in hospitals, and (3) can be planned in advance without
      sophisticated public consultation about likely ethical dilemmas.
FAU - Trotter, Griffin
AU  - Trotter G
AD  - Albert Gnaegi Center for Health Care Ethics, Saint Louis University, USA.
      trotterc@slu.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
RN  - 0 (Aerosols)
RN  - EC 3.4.24.69 (Botulinum Toxins)
SB  - IM
MH  - Aerosols
MH  - Botulinum Toxins/poisoning
MH  - Chemical Terrorism
MH  - Cyclonic Storms
MH  - Delivery of Health Care/ethics/*standards
MH  - Disaster Planning/trends
MH  - *Disasters
MH  - Health Resources/ethics/*supply & distribution
MH  - Humans
MH  - Influenza, Human/epidemiology
MH  - Pandemics
MH  - Relief Work
MH  - *Respiration, Artificial/ethics/instrumentation
MH  - Respiratory Insufficiency/etiology/therapy
MH  - Standard of Care/*ethics/standards
MH  - Triage/*ethics/standards
MH  - *Ventilators, Mechanical/ethics/supply & distribution
EDAT- 2011/02/15 06:00
MHDA- 2011/03/11 06:00
CRDT- 2011/02/15 06:00
PHST- 2011/02/15 06:00 [entrez]
PHST- 2011/02/15 06:00 [pubmed]
PHST- 2011/03/11 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2010 Winter;21(4):294-307.


PMID- 21313862
OWN - NLM
STAT- MEDLINE
DCOM- 20110310
LR  - 20181201
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 21
IP  - 4
DP  - 2010 Winter
TI  - Family participation in the care of patients in public health disasters.
PG  - 288-93
AB  - The ethical implications of disaster planning garner increasing scrutiny. The
      role of families in disaster efforts is a topic that requires additional ethical 
      examination. This article reviews the potential roles for families before and
      during disasters, with particular attention to the impact on children and
      vulnerable elderly patients. The potential positive and negative impact of family
      participation in different aspects of healthcare and disaster efforts is
      assessed.
FAU - Powell, Tia
AU  - Powell T
AD  - Montefiore-Einstein Center for Bioethics, Bronx, NewYork, USA.
      tpowell@montefiore.org
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Caregivers
MH  - Delivery of Health Care/*organization & administration/standards
MH  - *Disaster Planning/organization & administration
MH  - Disasters
MH  - Frail Elderly
MH  - Health Resources/*supply & distribution
MH  - Hospitals/*standards
MH  - Humans
MH  - Infection Control
MH  - *Public Health
MH  - Resuscitation Orders
MH  - Ventilators, Mechanical/supply & distribution
MH  - Workforce
EDAT- 2011/02/15 06:00
MHDA- 2011/03/11 06:00
CRDT- 2011/02/15 06:00
PHST- 2011/02/15 06:00 [entrez]
PHST- 2011/02/15 06:00 [pubmed]
PHST- 2011/03/11 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2010 Winter;21(4):288-93.


PMID- 21313861
OWN - NLM
STAT- MEDLINE
DCOM- 20110310
LR  - 20110214
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 21
IP  - 4
DP  - 2010 Winter
TI  - Bedside ethics and health system catastrophe: imagine if you will...
PG  - 285-7
AB  - Preparations for large-scale disasters have tended to focus on triage schema,
      stockpiling of materials, and other logistical concerns. Less attention has been 
      given to the myriad of distressing and almost unthinkable ethically charged
      dilemmas that will emerge at the bedside during a catastrophe, and how they may
      be best managed. Yet, it is these bedside issues that may limit or thwart the
      effectiveness of disaster planning, and, therefore, they ought to be carefully
      considered.
FAU - Berger, Jeffrey T
AU  - Berger JT
AD  - SUNY Stony Brook School of Medicine, NewYork, USA. jberger@winthrop.org
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
MH  - *Delivery of Health Care/ethics/organization & administration/standards
MH  - *Disaster Planning/trends
MH  - Disasters
MH  - Emergency Treatment/ethics/standards
MH  - Humans
MH  - Triage/ethics/organization & administration/standards
EDAT- 2011/02/15 06:00
MHDA- 2011/03/11 06:00
CRDT- 2011/02/15 06:00
PHST- 2011/02/15 06:00 [entrez]
PHST- 2011/02/15 06:00 [pubmed]
PHST- 2011/03/11 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2010 Winter;21(4):285-7.


PMID- 21313860
OWN - NLM
STAT- MEDLINE
DCOM- 20110310
LR  - 20110214
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 21
IP  - 4
DP  - 2010 Winter
TI  - A possible application of care-based ethics to people with disabilities during a 
      pandemic.
PG  - 275-83
AB  - Should people with exceptionally profound disabilities be given an equal chance
      of surviving a pandemic, even when their care might require a greater use of
      limited medical resources? How might an ethics of care be used to shape a policy 
      regarding these patients?
FAU - Howe, Edmund G
AU  - Howe EG
AD  - Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
MH  - Advisory Committees
MH  - Caregivers/*ethics/psychology
MH  - *Disabled Persons
MH  - *Emotions
MH  - Ethical Theory
MH  - Health Care Rationing/*ethics
MH  - Health Resources/*supply & distribution
MH  - Humans
MH  - *Interpersonal Relations
MH  - New Zealand
MH  - *Pandemics
MH  - Residence Characteristics
EDAT- 2011/02/15 06:00
MHDA- 2011/03/11 06:00
CRDT- 2011/02/15 06:00
PHST- 2011/02/15 06:00 [entrez]
PHST- 2011/02/15 06:00 [pubmed]
PHST- 2011/03/11 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2010 Winter;21(4):275-83.


PMID- 21312400
OWN - NLM
STAT- MEDLINE
DCOM- 20110303
LR  - 20191112
IS  - 1866-3370 (Print)
IS  - 1866-3370 (Linking)
VI  - 4
DP  - 2010
TI  - Antipsychotic dosing and drug delivery.
PG  - 141-77
AB  - This chapter addresses the current state of affairs regarding proposed mechanism 
      of action for antipsychotic medications and how this mechanism relates to dosing 
      and delivery strategies. The initial portion describes the history of
      antipsychotic medication, including key discoveries that contribute to the
      dopamine hypothesis of schizophrenia and provide evidence that dopamine D2
      receptor antagonism remains the most copasetic explanation for both determination
      of dose and degree of efficacy for current antipsychotic medications. Early
      observations regarding the unique properties of clozapine and how those
      observations led to the misconception and misnomer of atypicality are also
      discussed. Subsequent sections relate the dosing of available medications using
      chlorpromazine equivalents, with a discussion of non-D2-related mechanisms to
      antipsychotic effects. The balance of the chapter explores the temporal pattern
      of receptor occupancy as a key determinant of antipsychotic effectiveness, noting
      that continuous infusion would present the optimal method of treatment. In
      addition to the pharmacodynamic benefits of continuous long-term delivery
      systems, the incidence, causes, and clinical consequences of poor adherence are
      addressed. These observations are then discussed in the context of clinical
      studies and meta-analyses, demonstrating superiority of long-term depot
      preparations over oral administration. However, despite overwhelming evidence in 
      favor of long-term delivery systems, few options are available to provide such
      ideal medication delivery profiles. Barriers to creating traditional depot
      preparations for a large number of antipsychotic agents, as well as efforts to
      address these limitations with polymer-based microspheres are described. The
      potential extension of current formulations to very long-term delivery implants
      using biodegradable and nonbiodegradable platforms is then described. Benefits as
      well as limitations of such systems are discussed with respect to clinical and
      ethical issues as well as a brief description of potential regulatory and
      logistic barriers to developing better delivery options. In summary, this chapter
      describes the basis for relating the dose of all existing antipsychotic
      medications to dopamine D2 receptor affinity and the potential contribution of
      continuous occupancy to enhanced efficacy through superior biological effects and
      improved adherence.
FAU - Rabin, Cara R
AU  - Rabin CR
AD  - Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892,
      USA. cara.rabin@gmail.com
FAU - Siegel, Steven J
AU  - Siegel SJ
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Curr Top Behav Neurosci
JT  - Current topics in behavioral neurosciences
JID - 101535383
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Biocompatible Materials)
RN  - 0 (Receptors, Dopamine)
SB  - IM
MH  - Animals
MH  - Antipsychotic Agents/*administration & dosage
MH  - Biocompatible Materials
MH  - Dose-Response Relationship, Drug
MH  - *Drug Delivery Systems
MH  - Humans
MH  - Medication Adherence
MH  - Models, Biological
MH  - Receptors, Dopamine/drug effects/metabolism
MH  - Schizophrenia/*drug therapy/metabolism
EDAT- 2011/02/12 06:00
MHDA- 2011/03/04 06:00
CRDT- 2011/02/12 06:00
PHST- 2011/02/12 06:00 [entrez]
PHST- 2011/02/12 06:00 [pubmed]
PHST- 2011/03/04 06:00 [medline]
AID - 10.1007/7854_2010_46 [doi]
PST - ppublish
SO  - Curr Top Behav Neurosci. 2010;4:141-77. doi: 10.1007/7854_2010_46.


PMID- 21311630
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20220311
IS  - 1790-8019 (Electronic)
IS  - 1108-4189 (Linking)
VI  - 14
IP  - 4
DP  - 2010 Oct
TI  - The introduction of medical humanities in the undergraduate curriculum of Greek
      medical schools: challenge and necessity.
PG  - 241-3
AB  - BACKGROUND AND AIM: Medical humanities is a multidisciplinary field, consisting
      of humanities (theory of literature and arts, philosophy, ethics, history and
      theology), social sciences (anthropology, psychology and sociology) and arts
      (literature, theater, cinema, music and visual arts), integrated in the
      undergraduate curriculum of Medical schools. The aim of the present study is to
      discuss medical humanities and support the necessity of introduction of a medical
      humanities course in the curriculum of Greek medical schools. MATERIALS, METHODS 
      AND RESULTS: Through the relevant Pub-Med search as well as taking into account
      various curricula of medical schools, it is evident that medical education today 
      is characterized by acquisition of knowledge and skills and development of
      medical values and attitudes. Clinical observation with the recognition of key
      data and patterns in the collected information, is crucial in the final medical
      decision, i.e. in the complex process, through which doctors accumulate data,
      reach conclusions and decide on therapy. All sciences included in medical
      humanities are important for the high quality education of future doctors. The
      practice of Medicine is in large an image-related science. The history of anatomy
      and art are closely related, already from the Renaissance time. Studies have
      shown that attendance of courses on art critics improves the observational skills
      of medical students. Literature is the source of information about the nature and
      source of human emotions and behavior and of narratives of illness, and increases
      imagination. Philosophy aids in the development of analytical and synthetical
      thinking. Teaching of history of medicine develops humility and aids in avoiding 
      the repetition of mistakes of the past, and quite often raises research and
      therapeutic skepticism. The comprehension of medical ethics and professional
      deontology guides the patient-doctor relationship, as well as the relations
      between physicians and their colleagues. The Medical Humanities course, which is 
      already integrated in the undergraduate curriculum of many medical schools of
      Europe, USA and Australia, includes lectures by experts and students
      presentations on the above-mentioned areas and could be offered, for a semester, 
      during the first years. CONCLUSION: The aim of Medical Humanities course is the
      development of imagination and interpretation of data through analytical complex 
      procedures, the development of skills of close observation and careful
      interpretation of the patient "language" and the enhancement of empathy for the
      patients, as well as the development of the physician-patient relationship and
      finally the conceptualization/construction of personal and professional values.
FAU - Batistatou, A
AU  - Batistatou A
FAU - Doulis, E A
AU  - Doulis EA
FAU - Tiniakos, D
AU  - Tiniakos D
FAU - Anogiannaki, A
AU  - Anogiannaki A
FAU - Charalabopoulos, K
AU  - Charalabopoulos K
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Hippokratia
JT  - Hippokratia
JID - 101296613
PMC - PMC3031316
OTO - NOTNLM
OT  - Greece
OT  - medical humanities
OT  - medical school
OT  - review
EDAT- 2011/02/12 06:00
MHDA- 2011/02/12 06:01
CRDT- 2011/02/12 06:00
PHST- 2011/02/12 06:00 [entrez]
PHST- 2011/02/12 06:00 [pubmed]
PHST- 2011/02/12 06:01 [medline]
PST - ppublish
SO  - Hippokratia. 2010 Oct;14(4):241-3.


PMID- 21309453
OWN - NLM
STAT- MEDLINE
DCOM- 20110712
LR  - 20201209
IS  - 0253-1933 (Print)
IS  - 0253-1933 (Linking)
VI  - 29
IP  - 3
DP  - 2010 Dec
TI  - Canine leishmaniosis and euthanasia in Italy: a critical legal-ethical analysis.
PG  - 537-48
AB  - The increasing awareness that control of zoonotic visceral leishmaniosis (ZVL)
      depends on effective control of canine leishmaniosis has promoted research into
      leishmanial infection in dogs, but has also encouraged the indiscriminate
      elimination of seropositive dogs. Public health campaigns in various parts of the
      world (e.g. in Brazil and China) are designed to reduce the incidence of human
      ZVL by targeting/killing dogs. However, not all situations are the same; in
      Italy, for example, there would be little support for this type of control
      measure because attitudes towards animals are different. Moreover, research has
      suggested that the destruction of seropositive dogs is a relatively ineffective
      control measure. In this context, the authors reflect on some epidemiological,
      ethical and juridical aspects, aiming to contribute to the discussion and to find
      more feasible solutions.
FAU - Passantino, A
AU  - Passantino A
AD  - Department of Veterinary Public Health, Faculty of Veterinary Medicine,
      University of Messina, Polo Universitario Annunziata, 98168 Messina, Italy.
      passanna@unime.it
FAU - Russo, M
AU  - Russo M
FAU - Coluccio, P
AU  - Coluccio P
LA  - eng
PT  - Journal Article
PL  - France
TA  - Rev Sci Tech
JT  - Revue scientifique et technique (International Office of Epizootics)
JID - 8712301
SB  - IM
MH  - Animals
MH  - Developed Countries
MH  - Dog Diseases/*prevention & control/transmission
MH  - Dogs
MH  - Euthanasia, Animal/*ethics/*legislation & jurisprudence
MH  - Human-Animal Bond
MH  - Humans
MH  - Italy
MH  - Leishmaniasis, Visceral/prevention & control/transmission/*veterinary
MH  - *Zoonoses/parasitology/transmission
EDAT- 2011/02/12 06:00
MHDA- 2011/07/13 06:00
CRDT- 2011/02/12 06:00
PHST- 2011/02/12 06:00 [entrez]
PHST- 2011/02/12 06:00 [pubmed]
PHST- 2011/07/13 06:00 [medline]
PST - ppublish
SO  - Rev Sci Tech. 2010 Dec;29(3):537-48.


PMID- 21308497
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1534-3146 (Electronic)
IS  - 1523-3847 (Linking)
VI  - 12
IP  - 1
DP  - 2010 Jan
TI  - Drug-resistant tuberculosis in sub-saharan Africa.
PG  - 36-45
LID - 10.1007/s11908-009-0074-7 [doi]
AB  - Drug-resistant tuberculosis (DRTB) is an emerging infectious disease threat to
      sub-Saharan Africa (SSA), particularly in the regions hit hardest by the HIV
      epidemic. Numerous challenges face clinicians and public health officials tasked 
      with combating DRTB in SSA. These include difficulties providing effective
      diagnosis, treatment, and prevention of this illness. Furthermore, combating DRTB
      requires addressing various legal and ethical complexities. A sustained
      commitment to investigating as well as implementing new diagnostic, therapeutic, 
      and preventative interventions is essential to defeating this threat.
FAU - Hafkin, Jeffrey
AU  - Hafkin J
AD  - Division of Infectious Diseases, Hospital of the University of Pennsylvania,
      University of Pennsylvania School of Medicine, 3 Silverstein, Suite E, 3400
      Spruce Street, Philadelphia, PA, 19104, USA, hafkin@gmail.com.
FAU - Gammino, Victoria M
AU  - Gammino VM
FAU - Amon, Joseph J
AU  - Amon JJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Curr Infect Dis Rep
JT  - Current infectious disease reports
JID - 100888983
EDAT- 2011/02/11 06:00
MHDA- 2011/02/11 06:01
CRDT- 2011/02/11 06:00
PHST- 2011/02/11 06:00 [entrez]
PHST- 2011/02/11 06:00 [pubmed]
PHST- 2011/02/11 06:01 [medline]
AID - 10.1007/s11908-009-0074-7 [doi]
PST - ppublish
SO  - Curr Infect Dis Rep. 2010 Jan;12(1):36-45. doi: 10.1007/s11908-009-0074-7.


PMID- 21308229
OWN - NLM
STAT- MEDLINE
DCOM- 20110830
LR  - 20190911
IS  - 1984-0446 (Electronic)
IS  - 0034-7167 (Linking)
VI  - 63
IP  - 6
DP  - 2010 Nov-Dec
TI  - [Autonomy in intensive care unit: let us start by caring ourselves].
PG  - 956-63
LID - S0034-71672010000600014 [pii]
AB  - This study, a qualitative investigation anchored in Foucaltian analysis with
      approximations to post-structuralist theory, explores the question of autonomy as
      one of the tensions of nursing performance/knowledge which can be discursively
      articulated to bioethics and to techno biomedicine. From such perspective, from
      the multiples vies that may emerge to completing a critical reading of the
      analyzed texts (articles produced by nurses) and of the interviews with intensive
      care nurses, the theme of autonomy was analytically explored from the concept of 
      self care, unfolding itself into categories which express privileging: morals as 
      obedience to the Law; conduct and morals concerning technical knowledge;
      self-governing in its confront with technique. These are configured as ethical
      possibilities for the intensive care nurse/subject, not as sequential or
      competitive stages, but connected and confluent in the experience of the current 
      historical period.
FAU - Vargas, Ambrosina Oliveira
AU  - Vargas AO
AD  - Universidade do Vale dos Sinos, Curso de Enfermagem, Sao Leopoldo, RS.
      maraav@terra.com.br
FAU - Ramos, Flavia Regina Souza
AU  - Ramos FR
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Autonomia na unidade de terapia intensiva: comecemos por cuidar de nos.
PL  - Brazil
TA  - Rev Bras Enferm
JT  - Revista brasileira de enfermagem
JID - 7910105
MH  - *Ethics, Nursing
MH  - *Intensive Care Units
MH  - *Nursing
MH  - *Professional Autonomy
EDAT- 2011/02/11 06:00
MHDA- 2011/08/31 06:00
CRDT- 2011/02/11 06:00
PHST- 2009/08/19 00:00 [received]
PHST- 2010/06/08 00:00 [accepted]
PHST- 2011/02/11 06:00 [entrez]
PHST- 2011/02/11 06:00 [pubmed]
PHST- 2011/08/31 06:00 [medline]
AID - S0034-71672010000600014 [pii]
AID - 10.1590/s0034-71672010000600014 [doi]
PST - ppublish
SO  - Rev Bras Enferm. 2010 Nov-Dec;63(6):956-63. doi: 10.1590/s0034-71672010000600014.


PMID- 21308205
OWN - NLM
STAT- MEDLINE
DCOM- 20110719
LR  - 20191112
IS  - 1726-4642 (Electronic)
IS  - 1726-4634 (Linking)
VI  - 27
IP  - 4
DP  - 2010 Oct-Dec
TI  - [Towards a national commission on health research ethics in Peru: reflections on 
      the routes and processes comparing viewpoints].
PG  - 621-8
LID - S1726-46342010000400020 [pii]
AB  - We performed a review of the constitution processes and functions of national
      commissions on health research ethics in Latin America and Europe countries,
      which are characterized by its relation with the legislation and governmental
      structures in health sector, but, especially, in almost totality of cases for
      being linked by the functioning of the Research Ethics Committees. On the basis
      of this review there are realized an initial balance sheet and perspectives of
      the conformation of a National Commission on Health Research Ethics in Peru.
FAU - Barboza, Marco
AU  - Barboza M
AD  - Comision de Seguridad Social, Congreso de la Republica, Lima, Peru.
      barbozamarco@yahoo.es
FAU - Minaya, Gabriela
AU  - Minaya G
FAU - Fuentes, Duilio
AU  - Fuentes D
LA  - spa
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Hacia una comision nacional de etica de la investigacion en salud en Peru:
      apuntes acerca de rutas y procesos en perspectiva comparada.
PL  - Peru
TA  - Rev Peru Med Exp Salud Publica
JT  - Revista peruana de medicina experimental y salud publica
JID - 101227566
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Ethics Committees, Research/*legislation & jurisprudence/*organization &
      administration
MH  - Peru
EDAT- 2011/02/11 06:00
MHDA- 2011/07/20 06:00
CRDT- 2011/02/11 06:00
PHST- 2011/02/11 06:00 [entrez]
PHST- 2011/02/11 06:00 [pubmed]
PHST- 2011/07/20 06:00 [medline]
AID - S1726-46342010000400020 [pii]
AID - 10.1590/s1726-46342010000400020 [doi]
PST - ppublish
SO  - Rev Peru Med Exp Salud Publica. 2010 Oct-Dec;27(4):621-8. doi:
      10.1590/s1726-46342010000400020.


PMID- 21305836
OWN - NLM
STAT- MEDLINE
DCOM- 20110318
LR  - 20211203
IS  - 1049-510X (Print)
IS  - 1049-510X (Linking)
VI  - 20
IP  - 4
DP  - 2010 Autumn
TI  - Comparisons of Latinos, African Americans, and Caucasians with multiple
      sclerosis.
PG  - 451-7
AB  - OBJECTIVE: Identify racial/ethnic differences among people with multiple
      sclerosis (MS) in demographics, MS disease characteristics, and health services
      received. PARTICIPANTS: We analyzed enrollment data from the Registry of the
      North American Research Committee on Multiple Sclerosis (NARCOMS) Project to
      compare 26,967 Caucasians, 715 Latinos, and 1,313 African Americans with MS.
      DESIGN: Racial/ethnic analyses of NARCOMS data focused on descriptive
      characteristics, using ANOVA and chi-square tests to identify significant
      differences in means and frequencies among Caucasians, Latinos, and African
      Americans. RESULTS: We identified significant racial/ethnic differences in
      demographics, MS disease characteristics, and treatments. Caucasians were older
      when first MS symptoms were experienced (30.1 years) and at MS diagnosis (37.4
      years) than Latinos (28.6 years and 34.5 years) or African Americans (29.8 years 
      and 35.8 years). Larger proportions of Latinos reported normal function for
      mobility and bladder/bowel function compared to Caucasians. Larger proportions of
      Latinos (44.2 percent) and African Americans (45.8 percent) reported at least
      mild depression compared to only 38.7 percent of Caucasians. Larger proportions
      of Latinos never received mental health care or care from rehabilitation
      specialists than Caucasians or African Americans. A larger proportion of African 
      Americans had never been treated by a neurologist specializing in MS and a
      smaller proportion of African Americans received care at a MS clinic than
      Caucasians or Latinos. CONCLUSIONS: Our findings highlight the need for future
      analyses to determine if age, disease duration, MS symptoms, and disability
      levels provide additional insights into racial/ethic differences in the use of
      MS-related providers.
FAU - Buchanan, Robert J
AU  - Buchanan RJ
AD  - Department of Political Science and Public Administration, Mississippi State
      University, PO Box PC, Mississippi State, MS, 39762, USA.
      rbuchanan@ps.msstate.edu
FAU - Zuniga, Miguel A
AU  - Zuniga MA
FAU - Carrillo-Zuniga, Genny
AU  - Carrillo-Zuniga G
FAU - Chakravorty, Bonnie J
AU  - Chakravorty BJ
FAU - Tyry, Tuula
AU  - Tyry T
FAU - Moreau, Rachel L
AU  - Moreau RL
FAU - Huang, Chunfeng
AU  - Huang C
FAU - Vollmer, Timothy
AU  - Vollmer T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ethn Dis
JT  - Ethnicity & disease
JID - 9109034
SB  - IM
MH  - African Americans/*statistics & numerical data
MH  - Analysis of Variance
MH  - Chi-Square Distribution
MH  - Disabled Persons/statistics & numerical data
MH  - Disease Progression
MH  - Female
MH  - Health Services/statistics & numerical data
MH  - Hispanic or Latino/*statistics & numerical data
MH  - Humans
MH  - Male
MH  - Multiple Sclerosis/*ethnology
MH  - Pilot Projects
MH  - Registries
MH  - United States/epidemiology
MH  - Whites/*statistics & numerical data
EDAT- 2011/02/11 06:00
MHDA- 2011/03/19 06:00
CRDT- 2011/02/11 06:00
PHST- 2011/02/11 06:00 [entrez]
PHST- 2011/02/11 06:00 [pubmed]
PHST- 2011/03/19 06:00 [medline]
PST - ppublish
SO  - Ethn Dis. 2010 Autumn;20(4):451-7.


PMID- 21302846
OWN - NLM
STAT- MEDLINE
DCOM- 20110329
LR  - 20191112
IS  - 0098-8588 (Print)
IS  - 0098-8588 (Linking)
VI  - 36
IP  - 4
DP  - 2010
TI  - Can we handle the truth? Legal fictions in the determination of death.
PG  - 540-85
AB  - Advances in life-saving technologies in the past few decades have challenged our 
      traditional understandings of death. People can be maintained on life-support
      even after permanently losing the ability to breathe spontaneously and remaining 
      unconscious and unable to interact meaningfully with others. In part because this
      group of people could help fulfill the growing need for organ donation, there has
      been a great deal of pressure on the way we determine death. The determination of
      death has been modified from the old way of understanding death as occurring when
      a person stops breathing, her heart stops beating, and she is cold to the touch. 
      Today, physicians determine death by relying on a diagnosis of total brain
      failure or by waiting a short while after circulation stops. Evidence has emerged
      that the conceptual bases for these approaches to determining death are
      fundamentally flawed and depart substantially from our biological and
      common-sense understandings of death. We argue that the current approach to
      determining death consists of two different types of unacknowledged legal
      fictions. These legal fictions were developed for practices that are largely
      ethically legitimate but need to be reconciled with the law. However, the
      considerable debate over the determination of death in the medical and scientific
      literature has not informed the public of the fact that our current
      determinations of death do not adequately establish that a person has died. It
      seems unlikely that this information can remain hidden for long. Given the
      instability of the status quo and the difficulty of making the substantial legal 
      changes required by complete transparency, we argue for a second-best policy
      solution of acknowledging the legal fictions involved in determining death. This 
      move in the direction of greater transparency may someday result in allowing us
      to face squarely these issues and effect the legal changes necessary to permit
      ethically appropriate vital organ transplantation. Finally, this paper also
      provides the beginnings of a taxonomy of legal fictions, concluding that a more
      systematic theoretical treatment of legal fictions is warranted to understand
      their advantages and disadvantages across a variety of legal domains.
FAU - Shah, Seema K
AU  - Shah SK
FAU - Miller, Franklin G
AU  - Miller FG
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Legal Case
PT  - Research Support, N.I.H., Intramural
PL  - England
TA  - Am J Law Med
JT  - American journal of law & medicine
JID - 7509572
SB  - IM
MH  - Advisory Committees
MH  - *Bioethical Issues
MH  - Brain Death/diagnosis/*legislation & jurisprudence
MH  - Humans
MH  - Tissue Donors/legislation & jurisprudence
MH  - Tissue and Organ Procurement/legislation & jurisprudence
MH  - United States
MH  - Withholding Treatment/legislation & jurisprudence
EDAT- 2011/02/10 06:00
MHDA- 2011/03/30 06:00
CRDT- 2011/02/10 06:00
PHST- 2011/02/10 06:00 [entrez]
PHST- 2011/02/10 06:00 [pubmed]
PHST- 2011/03/30 06:00 [medline]
AID - 10.1177/009885881003600402 [doi]
PST - ppublish
SO  - Am J Law Med. 2010;36(4):540-85. doi: 10.1177/009885881003600402.


PMID- 21302738
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20110209
IS  - 0020-6539 (Print)
IS  - 0020-6539 (Linking)
VI  - 60
IP  - 6
DP  - 2010 Dec
TI  - Illegal oral care: more than a legal issue.
PG  - 399-406
AB  - Affordable, safe and appropriate oral care, including preventive services, is not
      available for large parts of the world's population. In many low- and
      middle-income countries patients have to rely on a range of illegal oral care
      providers who are often socially accepted and part of the cultural context.
      Although filling a gap in service provision for poor populations, illegal
      provision of oral care is a serious public health problem, resulting in
      situations of low-quality care and risks for patients. It is a complex phenomenon
      going far beyond the legal context. It should be seen as a symptom of underlying 
      health system and society deficits, ranging from lack of access to care and
      health inequities to problems of governance and law-enforcement. This paper
      analyses the problem based on the country case of Guyana, explores the public
      health, legal, professional, social, economical and ethical dimensions of the
      problem and proposes a differential view on illegal practice by grouping illegal 
      oral care situations in four broad categories; each of them requiring different
      solutions to tackle underlying issues leading to the problem of illegal oral
      care.
FAU - Benzian, Habib
AU  - Benzian H
AD  - The HealthBureau Ltd, Berlin, Germany. habib.benzian@health-bureau.com
FAU - Jean, Joanes
AU  - Jean J
FAU - van Palenstein Helderman, Wim
AU  - van Palenstein Helderman W
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int Dent J
JT  - International dental journal
JID - 0374714
SB  - IM
MH  - Dental Care/*legislation & jurisprudence
MH  - Education, Dental
MH  - Fraud
MH  - Guyana
MH  - Health Services Accessibility
MH  - Humans
MH  - Licensure, Dental/*legislation & jurisprudence
MH  - Quackery
EDAT- 2011/02/10 06:00
MHDA- 2011/02/25 06:00
CRDT- 2011/02/10 06:00
PHST- 2011/02/10 06:00 [entrez]
PHST- 2011/02/10 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
PST - ppublish
SO  - Int Dent J. 2010 Dec;60(6):399-406.


PMID- 21302251
OWN - NLM
STAT- MEDLINE
DCOM- 20110729
LR  - 20181201
IS  - 1696-3547 (Electronic)
IS  - 0214-6282 (Linking)
VI  - 54
IP  - 10
DP  - 2010
TI  - Stem cells in biology and disease - ESTOOLS International Symposium.
PG  - 1399-404
LID - 10.1387/ijdb.103255sp [doi]
AB  - ESTOOLS was the first EU-funded project entirely devoted to the study of human
      embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). The final
      meeting of the consortium took place in Lisbon from 26 to 28 May 2010 and
      gathered 298 researchers from 27 countries. A dense programme of scientific
      sessions and outreach activities and an ethics workshop gave an all-round
      overview of the challenges, perspectives and ethical issues of this exciting
      field. The ESTOOLS consortium was launched in 2006 as a 4-year EU-funded 6th
      Framework (FP6) project, with a total funding of 12 million euro. The project has
      been the largest European consortium devoted to the study of human ESCs, teaming 
      up 21 research groups in 10 countries. After the discovery of human induced
      pluripotent stem cells (iPSCs) by Shinya Yamanaka and James Thomson in 2007, the 
      consortium opened a new workpackage dedicated to this groundbreaking field, and
      became the first to devote EU funding to study human iPSCs. The Lisbon meeting
      marked the end of the consortiums funding cycle, but it was more than a wrap-up
      of its overall work and achievements, providing a showcase of cutting-edge
      research in human pluripotent stem cells, with the participation of international
      leaders in the field.
FAU - Pistoi, Sergio
AU  - Pistoi S
AD  - ESTOOLS Public Information Officer. Arezzo, Tuscany, Italy.
      sergio@sergiopistoi.com
LA  - eng
PT  - Congress
PL  - Spain
TA  - Int J Dev Biol
JT  - The International journal of developmental biology
JID - 8917470
SB  - IM
MH  - Cell Differentiation
MH  - Cell Transdifferentiation
MH  - *Embryonic Stem Cells
MH  - Humans
MH  - *Induced Pluripotent Stem Cells
MH  - Models, Biological
MH  - *Neoplastic Stem Cells
MH  - Neurons/cytology
EDAT- 2011/02/09 06:00
MHDA- 2011/07/30 06:00
CRDT- 2011/02/09 06:00
PHST- 2011/02/09 06:00 [entrez]
PHST- 2011/02/09 06:00 [pubmed]
PHST- 2011/07/30 06:00 [medline]
AID - 103255sp [pii]
AID - 10.1387/ijdb.103255sp [doi]
PST - ppublish
SO  - Int J Dev Biol. 2010;54(10):1399-404. doi: 10.1387/ijdb.103255sp.


PMID- 21301599
OWN - NLM
STAT- MEDLINE
DCOM- 20110607
LR  - 20211020
IS  - 1553-6467 (Electronic)
IS  - 0002-9459 (Linking)
VI  - 74
IP  - 9
DP  - 2010 Nov 10
TI  - The influence of an elective introductory clinical research course on pharmacy
      student interest in pursuing research-based careers.
PG  - 165
AB  - OBJECTIVE: To assess the impact of an elective clinical research course on
      second- and third-year pharmacy students' knowledge of clinical research methods,
      training programs, career options, and interest in pursuing postgraduate
      training. DESIGN: A 2-credit hour elective course in clinical research was
      designed that included lectures, discussions, workshops, and in-class
      presentations related to study design and implementation, protocol synthesis,
      research evaluation, ethical and legal considerations, data analysis, and
      professional opportunities involving clinical research. Learner knowledge of
      these topics was assessed using several methods, including 3 assignments related 
      to research protocol, ethical documentation, and presentation. ASSESSMENT: A
      survey instrument designed to evaluate the effect the course had on pharmacy
      students' knowledge of clinical research methods and interest in pursuing
      postgraduate training in clinical research was administered. Students who
      completed the elective had a greater level of familiarity with research-related
      topics, training options, and career opportunities (p < 0.05) and a greater
      interest in pursuing a career in clinical research (p < 0.05) than did students
      in a matched control group. CONCLUSION: Taking a 2-credit hour elective course in
      clinical research increased pharmacy students' interest in pursuing a career in
      clinical research.
FAU - Overholser, Brian R
AU  - Overholser BR
AD  - Purdue University College of Pharmacy, Indianapolis, IN 46202, USA.
      boverhol@purdue.edu
FAU - Foster, David R
AU  - Foster DR
FAU - Henry, Joshua R
AU  - Henry JR
FAU - Plake, Kimberly S
AU  - Plake KS
FAU - Sowinski, Kevin M
AU  - Sowinski KM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Pharm Educ
JT  - American journal of pharmaceutical education
JID - 0372650
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biomedical Research/*education
MH  - *Career Choice
MH  - Curriculum
MH  - Data Collection
MH  - Education, Pharmacy/*methods
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Male
MH  - Students, Pharmacy/*statistics & numerical data
MH  - Young Adult
PMC - PMC2996755
OTO - NOTNLM
OT  - clinical research
OT  - elective course
OT  - translational research
EDAT- 2011/02/09 06:00
MHDA- 2011/06/08 06:00
CRDT- 2011/02/09 06:00
PHST- 2010/03/11 00:00 [received]
PHST- 2010/07/19 00:00 [accepted]
PHST- 2011/02/09 06:00 [entrez]
PHST- 2011/02/09 06:00 [pubmed]
PHST- 2011/06/08 06:00 [medline]
AID - 10.5688/aj7409165 [doi]
PST - ppublish
SO  - Am J Pharm Educ. 2010 Nov 10;74(9):165. doi: 10.5688/aj7409165.


PMID- 21300002
OWN - NLM
STAT- MEDLINE
DCOM- 20110322
LR  - 20160519
IS  - 1878-8769 (Electronic)
IS  - 1878-8750 (Linking)
VI  - 74
IP  - 1
DP  - 2010 Jul
TI  - Neuropsychologic impact of treatment modalities in subarachnoid hemorrhage:
      clipping is no different from coiling.
PG  - 129-38
LID - 10.1016/j.wneu.2010.05.009 [doi]
AB  - OBJECTIVE: This study assesses the impairment in activities of everyday life
      using a novel test battery following subarachnoid hemorrhage (SAH) and its
      treatment. METHODS: A one-off neuropsychologic assessment was conducted for all
      patients who agreed to participate in the study. The date of the interview was at
      least 12 months after the ictus. The aspects tested included attention, memory,
      mood, and executive functions. Thirty normal subjects were also assessed using
      the same battery of tests to act as controls. The data was analyzed using JMP,
      version 8.0.2. The project was approved by the local research ethics committee
      and was performed under the tenets of the Helsinki declaration. RESULTS: Analysis
      from 77 patients and 30 controls is presented. Patients in the SAH group had
      significant deficits of sustained attention and attentional switching and
      executive functions when compared to normal controls (P < 0.05, chi(2)). Within
      the SAH patient group, the deficits were independent of the subgroup to which the
      patients belonged (coiled, clipped, and perimesencephalic hemorrhage, P > 0.05,
      chi(2)). The perimesencephalic hemorrhage group had fewer deficits as compared to
      the coiled and clipped groups, but because there were very few patients in this
      group, statistical significance was not achieved for these results. CONCLUSION:
      Our results reflect a change in UK practice in treating aneurysms, the majority
      being treated with endovascular coiling. After more than 12 months postictus,
      attention and executive functions were found to be significantly impaired.
      Significant deficits remain in various cognitive domains following an SAH, but
      these appear to be independent of the treatment modality according to our data.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Mukerji, Nitin
AU  - Mukerji N
AD  - Department of Neurosurgery, James Cook University Hospital, Middlesbrough, United
      Kingdom. mukerji@rcsed.ac.uk
FAU - Holliman, Damian
AU  - Holliman D
FAU - Baisch, Stefanie
AU  - Baisch S
FAU - Noble, Adam
AU  - Noble A
FAU - Schenk, Thomas
AU  - Schenk T
FAU - Nath, Fred
AU  - Nath F
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - World Neurosurg
JT  - World neurosurgery
JID - 101528275
SB  - IM
MH  - Activities of Daily Living/classification
MH  - Adult
MH  - Aged
MH  - Brain Damage, Chronic/*diagnosis/etiology
MH  - Cognition Disorders/*diagnosis/etiology
MH  - *Craniotomy
MH  - *Embolization, Therapeutic
MH  - England
MH  - Female
MH  - Humans
MH  - Intracranial Aneurysm/*surgery
MH  - Male
MH  - Mental Status Schedule
MH  - Mesencephalon
MH  - Middle Aged
MH  - Neuropsychological Tests/*statistics & numerical data
MH  - Postoperative Complications/*diagnosis/etiology
MH  - Subarachnoid Hemorrhage/*surgery
MH  - *Surgical Instruments
EDAT- 2011/02/09 06:00
MHDA- 2011/03/23 06:00
CRDT- 2011/02/09 06:00
PHST- 2010/02/23 00:00 [received]
PHST- 2010/04/30 00:00 [accepted]
PHST- 2011/02/09 06:00 [entrez]
PHST- 2011/02/09 06:00 [pubmed]
PHST- 2011/03/23 06:00 [medline]
AID - S1878-8750(10)00204-4 [pii]
AID - 10.1016/j.wneu.2010.05.009 [doi]
PST - ppublish
SO  - World Neurosurg. 2010 Jul;74(1):129-38. doi: 10.1016/j.wneu.2010.05.009.


PMID- 21299730
OWN - NLM
STAT- MEDLINE
DCOM- 20110624
LR  - 20211203
IS  - 1365-2850 (Electronic)
IS  - 1351-0126 (Linking)
VI  - 18
IP  - 2
DP  - 2011 Mar
TI  - The shoulder: taking the strain during restraint.
PG  - 177-84
LID - 10.1111/j.1365-2850.2010.01670.x [doi]
AB  - The decision to use or utilize physical intervention techniques is a contentious 
      one. There has been much discussion on the complex legal and ethical dimensions
      framing the use of force. The risk of injury has also been considered in detail, 
      but almost all of the published work has focused on restraint asphyxia, the prone
      restraint hold and the use of particular pain compliance techniques such as the
      wrist flexion hold. This paper focuses on the structure and function of the
      shoulder and examines how physical interventions and a variety of risk factors
      can threaten its physical integrity. This paper is for practitioners such as
      training commissioners, trainers, frontline staff and investigators or regulators
      who have to make considered determinations on the potential immediate physical
      impact of a variety of holds and escape manoeuvres. Sound risk assessment must be
      premised on a sound understanding of anatomy and physiology.
CI  - (c) 2010 Blackwell Publishing.
FAU - Hollins, L P
AU  - Hollins LP
AD  - leehollins@winchesterscott.co.uk
FAU - Stubbs, B
AU  - Stubbs B
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20101222
PL  - England
TA  - J Psychiatr Ment Health Nurs
JT  - Journal of psychiatric and mental health nursing
JID - 9439514
MH  - Humans
MH  - *Mental Health Services
MH  - *Psychiatric Nursing
MH  - Restraint, Physical/*adverse effects
MH  - Risk Assessment
MH  - *Shoulder Injuries
MH  - Shoulder Joint/anatomy & histology
MH  - Sprains and Strains/*etiology
EDAT- 2011/02/09 06:00
MHDA- 2011/06/28 06:00
CRDT- 2011/02/09 06:00
PHST- 2011/02/09 06:00 [entrez]
PHST- 2011/02/09 06:00 [pubmed]
PHST- 2011/06/28 06:00 [medline]
AID - 10.1111/j.1365-2850.2010.01670.x [doi]
PST - ppublish
SO  - J Psychiatr Ment Health Nurs. 2011 Mar;18(2):177-84. doi:
      10.1111/j.1365-2850.2010.01670.x. Epub 2010 Dec 22.


PMID- 21299721
OWN - NLM
STAT- MEDLINE
DCOM- 20110624
LR  - 20161125
IS  - 1365-2850 (Electronic)
IS  - 1351-0126 (Linking)
VI  - 18
IP  - 2
DP  - 2011 Mar
TI  - A survey of staff attitudes and responses to people with dementia who are
      aggressive in residential care settings.
PG  - 97-104
LID - 10.1111/j.1365-2850.2010.01646.x [doi]
AB  - Aggression is reportedly common among older people with dementia in residential
      care. The attitudes of staff in care homes and strategies they use are under
      researched. Theoretical models that may be used to both understand and respond to
      such behaviour exist. They are the standard and person-centred paradigms. The aim
      of this study was to explore the views of nursing staff about aggressive
      behaviour in people with dementia and strategies used in practice. A survey of
      the attitudes of staff in six dementia care units using the Management of
      Aggression in People with Dementia Attitude Questionnaire was conducted including
      an audit of aggressive incidents using the Staff Observation Aggression
      Scale-Revised over a 3-month period. Staff expressed views reflective of a
      person-centred as opposed to standard paradigm. They viewed aggressive behaviour 
      by people with dementia as deriving from the environment, situation or
      interactions with others. Participants strongly supported interpersonal means of 
      responding to aggression, the moderate use of medication, and were largely
      opposed to physical restraint. Aggressive incidents were managed using less
      intrusive strategies such as distraction and de-escalation. Responses to
      aggressive behaviour, while pragmatic, were largely underpinned by a
      person-centred ethic as reflected in the attitudes expressed by staff.
CI  - (c) 2010 Blackwell Publishing.
FAU - Pulsford, D
AU  - Pulsford D
AD  - School of Nursing & Caring Sciences, University of Central Lancashire, Preston,
      Lancashire, UK.
FAU - Duxbury, J A
AU  - Duxbury JA
FAU - Hadi, M
AU  - Hadi M
LA  - eng
PT  - Journal Article
DEP - 20101015
PL  - England
TA  - J Psychiatr Ment Health Nurs
JT  - Journal of psychiatric and mental health nursing
JID - 9439514
MH  - Aggression/*psychology
MH  - *Attitude of Health Personnel
MH  - Dementia/*nursing/psychology
MH  - Female
MH  - Humans
MH  - Male
MH  - Nursing Staff/*psychology/statistics & numerical data
MH  - Population Surveillance
MH  - *Residential Facilities
MH  - Restraint, Physical/psychology/statistics & numerical data
MH  - *Surveys and Questionnaires
MH  - United Kingdom
EDAT- 2011/02/09 06:00
MHDA- 2011/06/28 06:00
CRDT- 2011/02/09 06:00
PHST- 2011/02/09 06:00 [entrez]
PHST- 2011/02/09 06:00 [pubmed]
PHST- 2011/06/28 06:00 [medline]
AID - 10.1111/j.1365-2850.2010.01646.x [doi]
PST - ppublish
SO  - J Psychiatr Ment Health Nurs. 2011 Mar;18(2):97-104. doi:
      10.1111/j.1365-2850.2010.01646.x. Epub 2010 Oct 15.


PMID- 21298966
OWN - NLM
STAT- MEDLINE
DCOM- 20110218
LR  - 20110207
IS  - 1268-6034 (Print)
IS  - 1268-6034 (Linking)
IP  - 86
DP  - 2010 Nov-Dec
TI  - [Promoting the dignity and respect of elderly people in institutions].
PG  - 33-4
AB  - How can caregivers avoid the mechanical nature of the repetitive care given to
      elderly people in institutions? As part of a training programme set up in the
      long-term care home of Saint-Pierre-le-Moutier, a group of caregivers considered 
      this question. On the basis of an ethical approach, they created tools to offer a
      form of dignified care which respects both the resident and the caregiver.
FAU - Harzau-Ugo, Huguette
AU  - Harzau-Ugo H
AD  - Irap Sante, Noisy-le-Grand.
FAU - Bouisson, Emmanuelle
AU  - Bouisson E
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Promouvoir la dignite et le respect de la personne agee en institution.
PL  - France
TA  - Soins Gerontol
JT  - Soins. Gerontologie
JID - 9616322
MH  - Aged
MH  - *Frail Elderly/psychology
MH  - France
MH  - Geriatric Nursing/ethics/*organization & administration
MH  - Health Promotion/ethics/*organization & administration
MH  - Humans
MH  - Institutionalization/ethics/*organization & administration
MH  - Nurse's Role
MH  - Nursing Homes/ethics/*organization & administration
MH  - *Patient Advocacy/ethics/legislation & jurisprudence/psychology
EDAT- 2011/02/09 06:00
MHDA- 2011/02/22 06:00
CRDT- 2011/02/09 06:00
PHST- 2011/02/09 06:00 [entrez]
PHST- 2011/02/09 06:00 [pubmed]
PHST- 2011/02/22 06:00 [medline]
PST - ppublish
SO  - Soins Gerontol. 2010 Nov-Dec;(86):33-4.


PMID- 21298961
OWN - NLM
STAT- MEDLINE
DCOM- 20110218
LR  - 20110207
IS  - 1268-6034 (Print)
IS  - 1268-6034 (Linking)
IP  - 86
DP  - 2010 Nov-Dec
TI  - [From one generation to another, the threats of the disintegration of social
      ties].
PG  - 20-3
AB  - In our modern societies, social ties are reflected in three forms of social
      relationships which merge with each other: social norms, local social networks
      and relationships within families. In times of abundance these three forms tend
      to lead to the same ethical attitude towards elderly and dependent people. Each
      agrees on the importance of providing a level of care which guarantees elderly
      people a state of well-being which we would all like to enjoy ourselves. In times
      of crisis however these three forms tend to fall out of synch with each other as 
      the expectations of one can contradict those of another. What are the risks of
      such a de-synchronisation in the support given to elderly people?
FAU - Blondel, Frederic
AU  - Blondel F
AD  - Laboratoire de changement social, Universite Paris-Denis Diderot.
FAU - Delzescaux, Sabine
AU  - Delzescaux S
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - D'une generation a l'autre, les menaces de delitement du lien social.
PL  - France
TA  - Soins Gerontol
JT  - Soins. Gerontologie
JID - 9616322
MH  - Aged
MH  - Family/*psychology
MH  - France
MH  - Geriatric Nursing/ethics/*organization & administration
MH  - Health Policy
MH  - Health Promotion
MH  - Humans
MH  - *Intergenerational Relations
MH  - *Social Behavior
MH  - Social Support
MH  - Social Values
EDAT- 2011/02/09 06:00
MHDA- 2011/02/22 06:00
CRDT- 2011/02/09 06:00
PHST- 2011/02/09 06:00 [entrez]
PHST- 2011/02/09 06:00 [pubmed]
PHST- 2011/02/22 06:00 [medline]
PST - ppublish
SO  - Soins Gerontol. 2010 Nov-Dec;(86):20-3.


PMID- 21298905
OWN - NLM
STAT- MEDLINE
DCOM- 20110502
LR  - 20110207
IS  - 0034-9356 (Print)
IS  - 0034-9356 (Linking)
VI  - 57 Suppl 2
DP  - 2010 Dec
TI  - [Prologue. Recommendations-Clinical practice guideline for subarachnoid
      hemorrhage caused by ruptured intracranial aneurysm].
PG  - S2-3
AB  - To provide evidence-based clinical practice guidelines for managing subarachnoid 
      hemorrhage due to spontaneous rupture of an intracranial aneurysm. The ultimate
      purpose of the guidelines is to contribute to improving quality of care and
      reduce unnecessary costs related to the application of futile treatments.
      Systematic review of the literature indexed in the principal databases. Articles 
      identified were categorized according to levels of evidence (1 to 5) and
      recommendations that could be derived were classified according to strength (A,
      B, and C). Some recommendations cannot be based on randomized controlled trials
      because the utility of certain practices is already clear; no one will
      investigate them or it would not be ethical to do so. We bore in mind that while 
      many current practices for which no evidence is available may be ineffective, but
      others may be highly effective even though proof may never be available.
      Therefore, the guidelines considered that lack of evidence must not be used as
      the only reason for limiting the use of a diagnostic method or treatment. Nor
      would lack of evidence be the reason for limiting the use of health care
      resources.
FAU - Ingelmo Ingelmo, I
AU  - Ingelmo Ingelmo I
AD  - Servicio Anestesiologia y Reanimacion, Hospital Universitario Ramon y Cajal,
      Madrid. iingelmo.hrc@salud.madrid.org
FAU - Rama Maceiras, P
AU  - Rama Maceiras P
FAU - Hernandez-Palazon, J
AU  - Hernandez-Palazon J
FAU - Fabregas Julia, N
AU  - Fabregas Julia N
LA  - spa
PT  - English Abstract
PT  - Introductory Journal Article
TT  - Recomendaciones-Guia de practica clinica en la hemorragia subaracnoidea por
      rotura de aneurisma intracraneal. Prologo.
PL  - Spain
TA  - Rev Esp Anestesiol Reanim
JT  - Revista espanola de anestesiologia y reanimacion
JID - 0134516
SB  - IM
MH  - *Aneurysm, Ruptured/complications
MH  - Humans
MH  - *Intracranial Aneurysm/complications
MH  - *Practice Guidelines as Topic
MH  - *Subarachnoid Hemorrhage/etiology/therapy
EDAT- 2011/02/09 06:00
MHDA- 2011/05/03 06:00
CRDT- 2011/02/09 06:00
PHST- 2011/02/09 06:00 [entrez]
PHST- 2011/02/09 06:00 [pubmed]
PHST- 2011/05/03 06:00 [medline]
PST - ppublish
SO  - Rev Esp Anestesiol Reanim. 2010 Dec;57 Suppl 2:S2-3.


PMID- 21298869
OWN - NLM
STAT- MEDLINE
DCOM- 20110415
LR  - 20110207
IS  - 0025-7818 (Print)
IS  - 0025-7818 (Linking)
VI  - 101 Suppl 2
DP  - 2010
TI  - [Work: disease and health. The role of occupational medicine].
PG  - 11-27
AB  - To assess the role of Occupational Medicine in the promotion of workers'health
      over the last forty years, the author studied the evolution of this discipline
      from a clinical-diagnostic approach to the current emphasis on prevention.
      However, it is stressed that in Occupational Medicine even preventive measures
      are based on clinical methodology, as for example in health surveillance, where
      the main tasks are the identification of individual hyper-susceptibility and the 
      assessment of early and reversible health effects due to occupational risks.
      Moreover, the traditional clinical-diagnostic approach is still of utmost
      importance. In fact, the classical occupational diseases do not present with the 
      specific clinical features of the recent past. Instead, today it is necessary to 
      evaluate whether occupational risk factors play a concomitant role in the origin 
      of diseases that affect the general population. Moreover, new occupational
      diseases are emerging, due to the continuous changes in manufacturing processes
      and work organization. To assess the role that Occupational Medicine has played
      in the binomial expression "disease-health", topics which particularly suit the
      Author's cultural background are considered and are used as "indicators" of the
      various scientific, cultural, social, economic, and legislative aspects that
      contribute to the professional development of Occupational Physicians. Important 
      results have been achieved over the last 40 years, however Occupational
      Physicians face new problems that impose a continuous updating process, not only 
      on medical topics but also on the development of technological processes. The
      laws and the recommendations of the most prestigious national and international
      organizations and the principles of the ICOH Code of Ethics should guide
      Occupational Physicians in their profession and their actions must imply full
      professional independence. They must acquire and maintain the necessary
      competence for their duties and adequate conditions to carry out their tasks
      according to good practice and professional ethics.
FAU - Alessio, L
AU  - Alessio L
AD  - Dipartimento di Medicina Sperimentale ed Applicata, Sezione di Medicina del
      Lavoro e Igiene Industriale, Universita degli Studi di Brescia.
      medlav@med.unibs.it
LA  - ita
PT  - English Abstract
PT  - Journal Article
TT  - Lavoro: malattia e salute. Il ruolo della Medicina del Lavoro.
PL  - Italy
TA  - Med Lav
JT  - La Medicina del lavoro
JID - 0401176
SB  - IM
MH  - Humans
MH  - Italy
MH  - *Occupational Diseases/epidemiology/prevention & control
MH  - Occupational Exposure
MH  - *Occupational Health/legislation & jurisprudence
MH  - *Occupational Medicine/legislation & jurisprudence/standards
EDAT- 2011/02/09 06:00
MHDA- 2011/04/19 06:00
CRDT- 2011/02/09 06:00
PHST- 2011/02/09 06:00 [entrez]
PHST- 2011/02/09 06:00 [pubmed]
PHST- 2011/04/19 06:00 [medline]
PST - ppublish
SO  - Med Lav. 2010;101 Suppl 2:11-27.


PMID- 21217611
OWN - NLM
STAT- MEDLINE
DCOM- 20110303
LR  - 20110110
IS  - 1565-4753 (Print)
IS  - 1565-4753 (Linking)
VI  - 8 Suppl 1
DP  - 2010 Dec
TI  - Fertility in men with Klinefleter syndrome.
PG  - 182-6
AB  - Klinefelter syndrome is an important cause of infertility among men. Although
      early development of the testes may appear normal, there is profound loss of germ
      cells during early-to-mid pubertal maturation. Spermatogenesis may be preserved
      in a small percent of tubules and these tubules may be available to artificial
      reproductive techniques for the retrieval and subsequent in vitro fertilization
      of extracted ova. Ethical and legal issues including risk-benefit consideration
      must be evaluated before implementing fertility preservation procedures in
      minors.
FAU - Houk, Christopher P
AU  - Houk CP
AD  - Department of Pediatrics, Medical College of Georgia, Augusta, GA 31403, USA.
      chouk@mcg.edu
FAU - Rogol, Alan
AU  - Rogol A
FAU - Lee, Peter A
AU  - Lee PA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Israel
TA  - Pediatr Endocrinol Rev
JT  - Pediatric endocrinology reviews : PER
JID - 101202124
SB  - IM
MH  - Adult
MH  - Fertility/*physiology
MH  - Humans
MH  - Klinefelter Syndrome/*physiopathology
MH  - Male
MH  - *Reproductive Techniques, Assisted
MH  - Spermatogenesis/physiology
MH  - Testis/physiopathology
EDAT- 2011/02/09 06:00
MHDA- 2011/03/04 06:00
CRDT- 2011/01/11 06:00
PHST- 2011/01/11 06:00 [entrez]
PHST- 2011/02/09 06:00 [pubmed]
PHST- 2011/03/04 06:00 [medline]
PST - ppublish
SO  - Pediatr Endocrinol Rev. 2010 Dec;8 Suppl 1:182-6.


PMID- 21296262
OWN - NLM
STAT- MEDLINE
DCOM- 20110520
LR  - 20110207
IS  - 1873-6963 (Electronic)
IS  - 0965-2299 (Linking)
VI  - 19
IP  - 1
DP  - 2011 Feb
TI  - Touching ethics: assessing the applicability of ethical rules for safe touch in
      CAM--outcomes of a CAM (complementary and alternative medicine) practitioner
      survey in Israel.
PG  - 12-8
LID - 10.1016/j.ctim.2010.12.001 [doi]
AB  - INTRODUCTION: Recently, ethical guidelines regarding safe touch in CAM were
      developed in Israel. Publishing ethical codes does not imply that they will
      actually help practitioners to meet ethical care standards. The effectiveness of 
      ethical rules depends on familiarity with the code and its content. In addition, 
      critical self-examination of the code by individual members of the profession is 
      required to reflect on the moral commitments encompassed in the code. METHODS:
      For the purpose of dynamic self-appraisal, we devised a survey to assess how CAM 
      practitioners view the suggested ethical guidelines for safe touch. We surveyed
      781 CAM practitioners regarding their perspectives on the safe-touch code.
      RESULTS: There was a high level of agreement with general statements regarding
      ethics pertaining to safe touch with a mean rate of agreement of 4.61 out of a
      maximum of 5. Practitioners concurred substantially with practice guidelines for 
      appropriate touch with a mean rate of agreement of 4.16 out of a maximum of 5.
      Attitudes toward the necessity to touch intimate areas for treatment purposes
      varied with 78.6% of respondents strongly disagreeing with any notion of need to 
      touch intimate areas during treatment. 7.9% neither disagreed nor agreed, 7.9%
      slightly agreed, and 7.6% strongly agreed with the need for touching intimate
      areas during treatment. There was a direct correlation between disagreement with 
      touching intimate areas for therapeutic purposes and agreement with general
      statements regarding ethics of safe touch (Spearman r=0.177, p<0.0001), and
      practice guidelines for appropriate touch (r=0.092, p=0.012). CONCLUSION: A
      substantial number of practitioners agreed with the code, although some findings 
      regarding the need to touch intimate area during treatments were disturbing. Our 
      findings can serve as a basis for ethical code development and implementation, as
      well as for educating CAM practitioners on the ethics of touch.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Schiff, Elad
AU  - Schiff E
AD  - Department of Internal Medicine, Bnai-Zion Hospital, Haifa, Israel.
      eschiff@bezeqint.net
FAU - Ben-Arye, Eran
AU  - Ben-Arye E
FAU - Shilo, Margalit
AU  - Shilo M
FAU - Levy, Moti
AU  - Levy M
FAU - Schachter, Leora
AU  - Schachter L
FAU - Weitchner, Na'ama
AU  - Weitchner N
FAU - Golan, Ofra
AU  - Golan O
FAU - Stone, Julie
AU  - Stone J
LA  - eng
PT  - Journal Article
DEP - 20101224
PL  - Scotland
TA  - Complement Ther Med
JT  - Complementary therapies in medicine
JID - 9308777
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - *Codes of Ethics
MH  - Complementary Therapies/*ethics/psychology
MH  - Delphi Technique
MH  - Female
MH  - Health Care Surveys
MH  - Health Maintenance Organizations
MH  - Health Personnel/*psychology
MH  - Humans
MH  - Israel
MH  - Male
MH  - Middle Aged
MH  - Practice Guidelines as Topic
MH  - *Touch
EDAT- 2011/02/08 06:00
MHDA- 2011/05/21 06:00
CRDT- 2011/02/08 06:00
PHST- 2010/04/26 00:00 [received]
PHST- 2010/10/29 00:00 [revised]
PHST- 2010/12/01 00:00 [accepted]
PHST- 2011/02/08 06:00 [entrez]
PHST- 2011/02/08 06:00 [pubmed]
PHST- 2011/05/21 06:00 [medline]
AID - S0965-2299(10)00138-X [pii]
AID - 10.1016/j.ctim.2010.12.001 [doi]
PST - ppublish
SO  - Complement Ther Med. 2011 Feb;19(1):12-8. doi: 10.1016/j.ctim.2010.12.001. Epub
      2010 Dec 24.


PMID- 21294337
OWN - NLM
STAT- MEDLINE
DCOM- 20110208
LR  - 20110204
IS  - 0023-7205 (Print)
IS  - 0023-7205 (Linking)
VI  - 107
IP  - 50
DP  - 2010 Dec 15-21
TI  - [Is there an ethical difference between euthanasia and sedation therapy?].
PG  - 3221-2; discussion 3222-3
FAU - Karlsson, Marit
AU  - Karlsson M
AD  - Karolinska institutet. marit.karlsson@ki.se
FAU - Strang, Peter
AU  - Strang P
LA  - swe
PT  - Journal Article
TT  - Finns det en etisk skillnad mellan dodshjalp och sederingsterapi?
PL  - Sweden
TA  - Lakartidningen
JT  - Lakartidningen
JID - 0027707
RN  - 0 (Hypnotics and Sedatives)
SB  - IM
MH  - Euthanasia/*ethics
MH  - Evidence-Based Medicine
MH  - Humans
MH  - Hypnotics and Sedatives/*administration & dosage
MH  - Palliative Care/*ethics
MH  - Patient Participation
MH  - Practice Guidelines as Topic
MH  - Terminal Care/*ethics
EDAT- 2011/02/08 06:00
MHDA- 2011/02/09 06:00
CRDT- 2011/02/08 06:00
PHST- 2011/02/08 06:00 [entrez]
PHST- 2011/02/08 06:00 [pubmed]
PHST- 2011/02/09 06:00 [medline]
PST - ppublish
SO  - Lakartidningen. 2010 Dec 15-21;107(50):3221-2; discussion 3222-3.


PMID- 21057431
OWN - NLM
STAT- MEDLINE
DCOM- 20110318
LR  - 20101108
IS  - 0353-5053 (Print)
IS  - 0353-5053 (Linking)
VI  - 22 Suppl 1
DP  - 2010 Nov
TI  - Deep brain stimulation for psychiatric disorders.
PG  - S162
AB  - Research on DBS for psychiatric disorders is being carried out in several areas, 
      including obsessive- compulsive disorder, major depression, addictions,
      Tourette's syndrome and eating disorders. The results in the literature are
      described. The need for rigorous screening by interdisciplinary and ethical teams
      is explained. The need for pooling patients across different centres, with common
      treatment protocols, in order to achieve necessary large-scale studies in
      psychiatric DBS with long-term follow-up is pointed out.
FAU - Gabriels, Loes
AU  - Gabriels L
AD  - University Hospitals Leuven, Katholieke Universiteit Leuven, Belgium.
      loes.gabriels@uzleuven.be
LA  - eng
PT  - Journal Article
PL  - Croatia
TA  - Psychiatr Danub
JT  - Psychiatria Danubina
JID - 9424753
SB  - IM
MH  - Cooperative Behavior
MH  - *Deep Brain Stimulation
MH  - Follow-Up Studies
MH  - Humans
MH  - Interdisciplinary Communication
MH  - Mental Disorders/physiopathology/*therapy
MH  - Patient Care Team
EDAT- 2011/02/08 06:00
MHDA- 2011/03/19 06:00
CRDT- 2010/11/09 06:00
PHST- 2010/11/09 06:00 [entrez]
PHST- 2011/02/08 06:00 [pubmed]
PHST- 2011/03/19 06:00 [medline]
PST - ppublish
SO  - Psychiatr Danub. 2010 Nov;22 Suppl 1:S162.


PMID- 21057428
OWN - NLM
STAT- MEDLINE
DCOM- 20110318
LR  - 20101108
IS  - 0353-5053 (Print)
IS  - 0353-5053 (Linking)
VI  - 22 Suppl 1
DP  - 2010 Nov
TI  - Bipolar disorder in Enugu, South East Nigeria: demographic and diagnostic
      characteristics of patients.
PG  - S152-7
AB  - BACKGROUND AND OBJECTIVES: bipolar disorder is a severe mental disorder that has 
      been widely studied in developed countries. Very few studies of this disorder
      exist in developing countries. The objective of this study was to describe the
      demographic and diagnostic characteristics of bipolar patients in Enugu, South
      East Nigeria. SUBJECTS AND METHOD: the design of the study was cross-sectional.
      The study was carried out in Federal Neuropsychiatric Hospital Enugu (FNPHE) and 
      in a Private Psychiatrist's Office (PPO) in Enugu, South East Nigeria. 94
      patients were recruited to take part in the study. 49 patients were included from
      the FNPHE and 45 patients from the PPO. The two groups of patients differed only 
      in terms of mood at study entry. Patients were included in the study if they had 
      been diagnosed bipolar, if they were attending the FNPHE as outpatients,
      inpatients or were receiving emergency treatment or if they were attending the
      PPO for follow-up and if they had given their consent to participate in the
      study. The patients responded to a structured questionnaire used to elicit
      demographic and diagnostic characteristics. This questionnaire was administered
      by one of the authors (EJ). Each patient was also interviewed with the Mini
      International Neuropsychiatric Interview (MINI) for Bipolar Disorder Studies
      version 5.0.0. This MINI assessment was done by (MO). All the data were collected
      in a specially prepared data collection form. The demographic factors reported on
      included gender, age, marital status, level of education and employment status.
      The reported diagnostic and illness characteristics included age at onset of
      illness, mood at study entry and mood at onset of illness. The data were analyzed
      using SPSS version 11.5. Frequencies were run on demographic characteristics
      while means and standard deviations were calculated for continuous variables. The
      study was approved by the Research Ethics Committee of the FNPHE. RESULTS: the
      majority of the sample (68.1%) met the criteria for bipolar I disorder. The mean 
      age of patients was 33.17 (SD = 11.87) years and mean duration of bipolar illness
      was 9.6 (SD = 8.9) years. Among the 94 patients, 58.8% were males. The mean age
      at onset of illness for the whole group was 22.9 (SD = 8.3) years. CONCLUSION:
      the current report is probably the first on bipolar disorder in this part of
      Africa. It will serve as an impetus to conduct more research on the topic
      especially since some important findings are similar to what had been recorded
      from both developed and developing countries.
FAU - Onyeama, Mbadiwe
AU  - Onyeama M
AD  - Department of Psychological Medicine, University of Nigeria Teaching Hospital,
      Enugu 400001, Nigeria. gabriel.onyeama@unn.edu.ng
FAU - Agomoh, Ahamefule
AU  - Agomoh A
FAU - Jombo, Efiong
AU  - Jombo E
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Croatia
TA  - Psychiatr Danub
JT  - Psychiatria Danubina
JID - 9424753
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Bipolar Disorder/*diagnosis/*epidemiology/psychology
MH  - Cross-Cultural Comparison
MH  - Cross-Sectional Studies
MH  - *Developing Countries
MH  - Female
MH  - Hospitals, Psychiatric/organization & administration/statistics & numerical data
MH  - Hospitals, Public/organization & administration/statistics & numerical data
MH  - Humans
MH  - Interview, Psychological
MH  - Male
MH  - Mental Status Schedule
MH  - Middle Aged
MH  - Nigeria
MH  - Young Adult
EDAT- 2011/02/08 06:00
MHDA- 2011/03/19 06:00
CRDT- 2010/11/09 06:00
PHST- 2010/11/09 06:00 [entrez]
PHST- 2011/02/08 06:00 [pubmed]
PHST- 2011/03/19 06:00 [medline]
PST - ppublish
SO  - Psychiatr Danub. 2010 Nov;22 Suppl 1:S152-7.


PMID- 21293546
OWN - NLM
STAT- MEDLINE
DCOM- 20110607
LR  - 20191112
IS  - 1213-8118 (Print)
IS  - 1213-8118 (Linking)
VI  - 154
IP  - 4
DP  - 2010 Dec
TI  - Mallampati test as a predictor of laryngoscopic view.
PG  - 339-43
AB  - AIM: To determine the accuracy of the modified Mallampati test for predicting
      difficult tracheal intubation. DESIGN: A cross-sectional, clinical,
      observational, non-blinded study. A quality analysis of anesthetic care. SETTING:
      Operating theatres and department of anesthesiology in a university hospital.
      MATERIAL AND METHODS: Following the local ethics committee approval and patients'
      informed consent to anesthesia, all adult patients (> 18 yrs) presenting for any 
      type of non-emergency surgical procedures under general anesthesia requiring
      endotracheal intubation were enrolled. Prior to anesthesia, Samsoon and Young's
      modification of the Mallampati test (modified Mallampati test) was performed.
      Following induction, the anesthesiologist described the laryngoscopic view using 
      the Cormack-Lehane scale. Classes 3 or 4 of the modified Mallampati test were
      considered a predictor of difficult intubation. Grades 3 or 4 of the
      Cormack-Lehane classification of the laryngoscopic view were defined as impaired 
      glottic exposure. The sensitivity, specificity, positive and negative predictive 
      value, relative risk, likelihood ratio and accuracy of the modified Mallampati
      test were calculated on 2x2 contingency tables. RESULTS: Of the total 1,518
      patients enrolled, 48 had difficult intubation (3.2%). We failed to detect as
      many as 35.4% patients in whom glottis exposure during direct laryngoscopy was
      inadequate (sensitivity 0.646). Compared to the original article by Mallampati,
      we found lower specificity (0.824 vs. 0.995), lower positive predictive value
      (0.107 vs. 0.933), higher negative predictive value (0.986 vs. 0.928), lower
      likelihood ratio (3.68 vs. 91.0) and accuracy (0.819 vs. 0.929). CONCLUSION: When
      used as a single examination, the modified Mallampati test is of limited value in
      predicting difficult intubation.
FAU - Adamus, Milan
AU  - Adamus M
AD  - Department of Anesthesiology and Resuscitation, University Hospital Olomouc,
      Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic.
      milan.adamus@seznam.cz
FAU - Fritscherova, Sarka
AU  - Fritscherova S
FAU - Hrabalek, Lumir
AU  - Hrabalek L
FAU - Gabrhelik, Tomas
AU  - Gabrhelik T
FAU - Zapletalova, Jana
AU  - Zapletalova J
FAU - Janout, Vladimir
AU  - Janout V
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Czech Republic
TA  - Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
JT  - Biomedical papers of the Medical Faculty of the University Palacky, Olomouc,
      Czechoslovakia
JID - 101140142
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anesthesia, General/*methods
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - *Intubation, Intratracheal
MH  - *Laryngoscopy
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Sensitivity and Specificity
EDAT- 2011/02/05 06:00
MHDA- 2011/06/08 06:00
CRDT- 2011/02/05 06:00
PHST- 2011/02/05 06:00 [entrez]
PHST- 2011/02/05 06:00 [pubmed]
PHST- 2011/06/08 06:00 [medline]
AID - 10.5507/bp.2010.051 [doi]
PST - ppublish
SO  - Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2010 Dec;154(4):339-43. doi:
      10.5507/bp.2010.051.


PMID- 21292217
OWN - NLM
STAT- MEDLINE
DCOM- 20110617
LR  - 20211020
IS  - 1878-7452 (Electronic)
IS  - 1878-7452 (Linking)
VI  - 68
IP  - 1
DP  - 2011 Jan-Feb
TI  - "Reality surgery"--a research ethics perspective on the live broadcast of
      surgical procedures.
PG  - 58-61
LID - 10.1016/j.jsurg.2010.08.009 [doi]
AB  - In recent years, the live broadcasting of medical and surgical procedures has
      gained worldwide popularity. While the practice has appropriately been met with
      concerns for patient safety and privacy, many physicians tout the merits of real 
      time viewing as a form of investigation, accelerating the process leading to
      adoption or abolition of newer techniques or technologies. This view introduces a
      new series of ethical considerations that need to be addressed. As such, this
      article considers, from a research ethics perspective, the use of live surgical
      procedure broadcast for investigative purposes.
CI  - Copyright (c) 2011 Association of Program Directors in Surgery. Published by
      Elsevier Inc. All rights reserved.
FAU - Williams, Judson B
AU  - Williams JB
AD  - Duke Clinical Research Institute, Department of Surgery, Duke University Medical 
      Center, Durham, North Carolina 27710, USA.
FAU - Mathews, Robin
AU  - Mathews R
FAU - D'Amico, Thomas A
AU  - D'Amico TA
LA  - eng
GR  - U01 HL088953/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20101105
PL  - United States
TA  - J Surg Educ
JT  - Journal of surgical education
JID - 101303204
SB  - IM
MH  - Codes of Ethics
MH  - *Confidentiality
MH  - Ethics, Research
MH  - General Surgery/*education/*ethics/methods
MH  - Humans
MH  - Mass Media/*ethics/statistics & numerical data
MH  - Needs Assessment
MH  - North Carolina
MH  - Patient Rights/ethics
MH  - Physician-Patient Relations/ethics
MH  - Television/statistics & numerical data
PMC - PMC3674879
MID - NIHMS475331
EDAT- 2011/02/05 06:00
MHDA- 2011/06/18 06:00
CRDT- 2011/02/05 06:00
PHST- 2010/07/28 00:00 [received]
PHST- 2010/08/23 00:00 [revised]
PHST- 2010/08/26 00:00 [accepted]
PHST- 2011/02/05 06:00 [entrez]
PHST- 2011/02/05 06:00 [pubmed]
PHST- 2011/06/18 06:00 [medline]
AID - S1931-7204(10)00240-0 [pii]
AID - 10.1016/j.jsurg.2010.08.009 [doi]
PST - ppublish
SO  - J Surg Educ. 2011 Jan-Feb;68(1):58-61. doi: 10.1016/j.jsurg.2010.08.009. Epub
      2010 Nov 5.


PMID- 21291293
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20220310
IS  - 1936-2692 (Electronic)
IS  - 1088-0224 (Linking)
VI  - 16
IP  - 12
DP  - 2010 Dec 1
TI  - "Under the radar": nurse practitioner prescribers and pharmaceutical industry
      promotions.
PG  - e358-62
AB  - OBJECTIVE: To assess nurse practitioners' interactions with pharmaceutical
      industry promotional activities and their perception of information reliability
      and self-reported prescribing behaviors. STUDY DESIGN: Self-administered online
      survey. METHODS: A nationally randomized sample of nurse practitioner prescribers
      was surveyed. Eligibility criteria included current clinical practice and
      licensure to prescribe medications in their state of practice. RESULTS: A total
      of 263 responses were analyzed. Almost all respondents (96%) reported regular
      contact with pharmaceutical sales representatives, and most (71%) reported
      receiving information on new drugs directly from pharmaceutical sales
      representatives some or most of the time. A large portion (66%) dispensed drug
      samples regularly to their patients, and 73% believed that samples were somewhat 
      or very helpful in learning about new drugs. Eighty-one percent of respondents
      thought that it was ethically acceptable to give out samples to anyone, and 90%
      believed that it was acceptable to attend lunch and dinner events sponsored by
      the pharmaceutical industry. Almost half (48%) stated that they were more likely 
      to prescribe a drug that was highlighted during a lunch or dinner event. Most
      respondents stated that it was ethically acceptable for speakers to be paid by
      industry. CONCLUSIONS: Nurse practitioner prescribers had extensive contact with 
      pharmaceutical industry promotional activities such as pharmaceutical
      representative contact, receipt of drug samples, and regular attendance at
      industry-sponsored meal events and continuing education programs. They reported
      that industry interface with nurse practitioner prescribers in the form of
      sponsored meals, education events, and paid speakers was ethically acceptable.
FAU - Ladd, Elissa C
AU  - Ladd EC
AD  - Institute of Health Professions School of Nursing, 36 First Ave, Boston, MA
      02129, USA. eladd@mghihp.edu
FAU - Mahoney, Diane Feeney
AU  - Mahoney DF
FAU - Emani, Srinivas
AU  - Emani S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101201
PL  - United States
TA  - Am J Manag Care
JT  - The American journal of managed care
JID - 9613960
CIN - Am J Manag Care. 2010;16(12):e356-7. PMID: 21291292
MH  - Clinical Competence
MH  - *Conflict of Interest
MH  - Drug Industry/*ethics/statistics & numerical data
MH  - Ethics, Medical
MH  - Female
MH  - Health Care Surveys
MH  - Humans
MH  - Male
MH  - Marketing/*ethics
MH  - Middle Aged
MH  - Nurse Practitioners/*ethics/statistics & numerical data
MH  - Practice Patterns, Physicians'/*ethics/statistics & numerical data
MH  - Self Report
EDAT- 2011/02/05 06:00
MHDA- 2011/06/03 06:00
CRDT- 2011/02/05 06:00
PHST- 2011/02/05 06:00 [entrez]
PHST- 2011/02/05 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
AID - 12784 [pii]
PST - epublish
SO  - Am J Manag Care. 2010 Dec 1;16(12):e358-62.


PMID- 21291095
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20110204
IS  - 0026-2102 (Print)
IS  - 0026-2102 (Linking)
VI  - 92
IP  - 12
DP  - 2010 Dec
TI  - Cognitive dissonance and ethics.
PG  - 48-50
FAU - Konvalinka, Keith
AU  - Konvalinka K
AD  - huzbirdy@aol.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Mich Dent Assoc
JT  - The Journal of the Michigan Dental Association
JID - 7505621
MH  - *Cognitive Dissonance
MH  - Conflict of Interest
MH  - Dentist-Patient Relations/ethics
MH  - Dentists/*ethics
MH  - *Ethics, Dental
MH  - Humans
MH  - Moral Development
EDAT- 2011/02/05 06:00
MHDA- 2011/02/25 06:00
CRDT- 2011/02/05 06:00
PHST- 2011/02/05 06:00 [entrez]
PHST- 2011/02/05 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
PST - ppublish
SO  - J Mich Dent Assoc. 2010 Dec;92(12):48-50.


PMID- 21291031
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20131121
IS  - 0024-7758 (Print)
IS  - 0024-7758 (Linking)
VI  - 55
IP  - 11-12
DP  - 2010 Nov-Dec
TI  - Ketorolac-mepivacaine lower uterine block for in-office endometrial ablation: a
      randomized, controlled trial.
PG  - 464-8
AB  - OBJECTIVE: To investigate the effectiveness of a nonsteroidal antiinflammatory
      drug (NSAID) administered in combination with a local anesthetic as a deep
      paracervical block for in-office endometrial ablations. STUDY DESIGN:
      Double-blind, placebo-controlled, randomized trial. Patients received either
      sublingual ketorolac (30 mg/1 mL) or a mepivacaine-only paracervical injection
      (standard group) or received sublingual saline (1 mL) and a ketorolac (30 mg/1
      mL)-mepivacaine paracervical block (NSAID group)for Gynecare Thermachoice III
      ablation (Ethicon, Inc., Somerville, New Jersey). All received sublingual
      ketorolac/placebo and 1 mg alprazolam sublingually 20 minutes preprocedure.
      Primary outcome was intraoperative pain control measured by 100 mm visual
      analogue scale. Secondary outcomes were postablation pain control (visual
      analogue scale [VAS]), postoperative use of narcotic analgesics and patient
      satisfaction in the first 24 hours (not satisfied, satisfied or very satisfied). 
      RESULTS: Twenty patients were randomized into each group. No statistically
      significant difference was noted in overall intraoperative VAS score (p = 0.81), 
      but there was a significant reduction in postoperative VAS (p = 0.01). There was 
      less need for postoperative analgesic use in the first 24 hours (p = 0.02) in the
      NSAID group. More patients were "very satisfied" in the NSAID group. CONCLUSION: 
      Injectable ketorolac-mepivacaine anesthetic solution functions well as a deep
      paracervical block for in-office gynecologic procedures, with better
      postoperative pain control than mepivacaine-alone protocols.
FAU - Chapa, Hector O
AU  - Chapa HO
AD  - Women's Specialty Center, Dallas, Texas, USA. chapamd@aol.com
FAU - Antonetti, Alfred G
AU  - Antonetti AG
FAU - Bakker, Ken
AU  - Bakker K
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - J Reprod Med
JT  - The Journal of reproductive medicine
JID - 0173343
RN  - 0 (Anesthetics, Local)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Narcotics)
RN  - B6E06QE59J (Mepivacaine)
RN  - YZI5105V0L (Ketorolac)
SB  - IM
MH  - Adult
MH  - Anesthetics, Local/*administration & dosage
MH  - Anti-Inflammatory Agents, Non-Steroidal/*administration & dosage
MH  - Cohort Studies
MH  - Double-Blind Method
MH  - Drug Therapy, Combination
MH  - Endometrial Ablation Techniques/*adverse effects
MH  - Female
MH  - Humans
MH  - Ketorolac/*administration & dosage
MH  - Mepivacaine/*administration & dosage
MH  - Narcotics/therapeutic use
MH  - Pain Measurement
MH  - Pain, Postoperative/diagnosis/etiology/*prevention & control
MH  - Patient Satisfaction
EDAT- 2011/02/05 06:00
MHDA- 2011/06/03 06:00
CRDT- 2011/02/05 06:00
PHST- 2011/02/05 06:00 [entrez]
PHST- 2011/02/05 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
PST - ppublish
SO  - J Reprod Med. 2010 Nov-Dec;55(11-12):464-8.


PMID- 21290361
OWN - NLM
STAT- MEDLINE
DCOM- 20110503
LR  - 20110203
IS  - 1469-5804 (Electronic)
IS  - 1357-6283 (Linking)
VI  - 23
IP  - 3
DP  - 2010 Nov
TI  - Listening styles of undergraduate health students.
PG  - 424
AB  - BACKGROUND: Concerns about poor communication in the medical and other healthcare
      professions are common in the empirical literature, with studies showing direct
      relationships between practitioners' effective listening and patients'
      satisfaction and less risk of litigation. Furthermore, people do not simply
      listen or not listen, rather they adopt particular listening styles, making the
      understanding and investigation of practitioner communication a complex topic.
      The objective of this study was to identify the listening styles of undergraduate
      health science students enrolled at one Australian university. METHODS: A
      cross-sectional study using a paper-based version of the Listening Styles Profile
      (LSP-16) was administered to a cohort of students enrolled in undergraduate
      education programs in eight different health disciplines: emergency health
      (paramedics), nursing, midwifery, occupational therapy, physiotherapy,
      nursing/emergency health dual degree, health science and nutrition and dietetics.
      The LSP-16 is a validated and reliable scale that assesses participants'
      preferences for each of four distinct listening style constructs. There were 1459
      health students eligible for inclusion in the study. Ethics approval was granted.
      RESULTS: A total of 860 students participated in the study (response rate of
      58%), of whom 87.2% (n=750) were female. Across the group, a strong preference
      was shown for the People Listening Style (LS), which is a listening style
      characterised by a concern for people's feelings and emotions. Otherwise, an
      unexpected amount of homogeneity in preferred listening style was found within
      the group of health science students. Female students reported a slightly
      stronger preference for the People LS, whereas males reported slightly stronger
      preferences for the Action LS and Content LS. There were no statistical
      differences in preference for LS by students' age or year level of undergraduate 
      enrolment. CONCLUSION: The health professional student participants of this study
      reported a preference for a range of listening styles, which is appropriate for
      many healthcare settings. However, a strong preference for the People LS and a
      moderate preference for the Content LS were evident. This study should be
      replicated with practicing professionals to establish if the demands of the
      workplace affect practitioners' listening style(s).
FAU - Brown, T
AU  - Brown T
AD  - Monash University, Melbourne, Victoria, Australia. ted.brown@med.monash.edu.au
FAU - Boyle, M J
AU  - Boyle MJ
FAU - Williams, B
AU  - Williams B
FAU - Molloy, A
AU  - Molloy A
FAU - McKenna, L
AU  - McKenna L
FAU - Palermo, C
AU  - Palermo C
FAU - Lewis, B
AU  - Lewis B
FAU - Molloy, L
AU  - Molloy L
LA  - eng
PT  - Journal Article
DEP - 20101023
PL  - India
TA  - Educ Health (Abingdon)
JT  - Education for health (Abingdon, England)
JID - 9607101
SB  - IM
MH  - Adult
MH  - Allied Health Personnel/education
MH  - *Attention
MH  - *Auditory Perception
MH  - Australia
MH  - Cross-Sectional Studies
MH  - Female
MH  - *Health Education
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Students
MH  - Universities
MH  - Young Adult
EDAT- 2011/02/04 06:00
MHDA- 2011/05/04 06:00
CRDT- 2011/02/04 06:00
PHST- 2011/02/04 06:00 [entrez]
PHST- 2011/02/04 06:00 [pubmed]
PHST- 2011/05/04 06:00 [medline]
AID - 424 [pii]
PST - ppublish
SO  - Educ Health (Abingdon). 2010 Nov;23(3):424. Epub 2010 Oct 23.


PMID- 21290357
OWN - NLM
STAT- MEDLINE
DCOM- 20110503
LR  - 20220409
IS  - 1469-5804 (Electronic)
IS  - 1357-6283 (Linking)
VI  - 23
IP  - 3
DP  - 2010 Nov
TI  - Innovative method of needs assessment for faculty development programs in a Gulf 
      medical school.
PG  - 389
AB  - BACKGROUND: Faculty development lays the foundation for the quality enhancement
      in medical education. However, programs are not always based on the needs of the 
      participants, and there is dearth of information on methods to derive faculty's
      needs. The Medical Education Unit at the University of Dammam, Saudi Arabia,
      carried out an innovative method to identify and prioritize faculty needs in
      order to plan future activities. METHODS: A questionnaire was designed,
      pilot-tested and administered to all faculty members (N=200). The respondents
      rated the perceived importance (high, moderate, low) and their performance (good,
      average, poor) on twelve competencies described in the literature. The ratings of
      perceived importance - high/moderate, and self-rated performance- average/poor,
      were summed up to determine priority rankings for continuing education. The
      respondents' rating of various continuing education activities, their willingness
      to participate and commit time, and their suggestions for strengthening faculty
      development were also analyzed. RESULTS: All the twelve competencies were
      perceived as 'highly important' by the subjects. They felt most confident in
      teaching in large and small groups, attitudes and ethical values, and decision
      making skills. The competencies prioritized as "gaps" were knowing how to develop
      learning resources, plan curriculum, evaluate courses and conduct research. The
      prioritized activities were specialized courses, orientation workshops for the
      new faculty, and training in educational research skills. This implied a
      multi-phased approach to faculty development. A majority (62.4%) were willing to 
      devote 2.2 hours per week to faculty development. Respondents suggested
      initiatives that should be undertaken by the Medical Education Unit and the
      broader institution. CONCLUSION: We demonstrated a participatory approach to
      needs assessment by identifying the gaps between "perceived importance" and
      "self-rated performance", as criteria for determining priorities. Findings also
      demonstrated the need for adopting a comprehensive approach to faculty
      development in which both departmental and organizational initiatives are
      required. Our findings are applicable to the Gulf Region context and our
      methodology can be applied anywhere.
FAU - Adkoli, B V
AU  - Adkoli BV
AD  - College of Medicine, King Faisal University, King Fahd Hospital of University,
      Al-khobar, KSA. bvadkoli@gmail.com
FAU - Al-Umran, K U
AU  - Al-Umran KU
FAU - Al-Sheikh, M H
AU  - Al-Sheikh MH
FAU - Deepak, K K
AU  - Deepak KK
LA  - eng
PT  - Journal Article
DEP - 20101120
PL  - India
TA  - Educ Health (Abingdon)
JT  - Education for health (Abingdon, England)
JID - 9607101
SB  - IM
MH  - Education, Medical
MH  - *Education, Medical, Continuing/organization & administration
MH  - *Faculty, Medical
MH  - Female
MH  - Humans
MH  - Male
MH  - *Needs Assessment
MH  - Saudi Arabia
MH  - *Schools, Medical
MH  - *Staff Development
MH  - Surveys and Questionnaires
EDAT- 2011/02/04 06:00
MHDA- 2011/05/04 06:00
CRDT- 2011/02/04 06:00
PHST- 2011/02/04 06:00 [entrez]
PHST- 2011/02/04 06:00 [pubmed]
PHST- 2011/05/04 06:00 [medline]
AID - 389 [pii]
PST - ppublish
SO  - Educ Health (Abingdon). 2010 Nov;23(3):389. Epub 2010 Nov 20.


PMID- 21290007
OWN - NLM
STAT- MEDLINE
DCOM- 20110809
LR  - 20161125
IS  - 1934-3418 (Electronic)
IS  - 1078-4519 (Linking)
VI  - 39
IP  - 10
DP  - 2010 Oct
TI  - Dermabond efficacy in total joint arthroplasty wounds.
PG  - 476-8
AB  - The goals of wound closure are a low infection rate and timely healing. Total
      joint arthroplasty (TJA) requires mobile recovery, and, therefore, a high-tension
      wound care environment. We conducted a study to compare the efficacy of
      high-viscosity Dermabond (Ethicon, Somerville, New Jersey) and the efficacy of
      surgical staples in healing high-tension, mobile surgical sites of TJA. Of 236
      total knee arthroplasties and 223 total hip arthroplasties (459 surgeries total),
      250 were performed with Dermabond and 209 with staples. According to chi2
      analysis, case and control infection rates were equivalent. Signs of acute
      inflammation (redness, drainage, dehiscence) also were statistically equivalent. 
      Absence of staples accounted for a significant decrease in tape blisters and skin
      abscesses. Dermabond is superior to staples in high-tension wound care.
FAU - Miller, Adam G
AU  - Miller AG
AD  - Orthopaedics, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
      adamgregorymiller@ymail.com
FAU - Swank, Michael L
AU  - Swank ML
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Am J Orthop (Belle Mead NJ)
JT  - American journal of orthopedics (Belle Mead, N.J.)
JID - 9502918
RN  - 0 (Cyanoacrylates)
RN  - 0 (Tissue Adhesives)
RN  - 6C655P1XVG (octyl 2-cyanoacrylate)
SB  - IM
MH  - Aged
MH  - Arthroplasty, Replacement, Hip/adverse effects/*methods
MH  - Arthroplasty, Replacement, Knee/adverse effects/*methods
MH  - Cyanoacrylates/*administration & dosage
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Patient Satisfaction
MH  - Surgical Wound Infection/prevention & control
MH  - Sutures
MH  - Tissue Adhesives/*administration & dosage
MH  - Treatment Outcome
MH  - Wound Healing/*drug effects
EDAT- 2011/02/04 06:00
MHDA- 2011/08/10 06:00
CRDT- 2011/02/04 06:00
PHST- 2011/02/04 06:00 [entrez]
PHST- 2011/02/04 06:00 [pubmed]
PHST- 2011/08/10 06:00 [medline]
PST - ppublish
SO  - Am J Orthop (Belle Mead NJ). 2010 Oct;39(10):476-8.


PMID- 21289886
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1861-8863 (Electronic)
IS  - 1861-8863 (Linking)
VI  - 6
DP  - 2010 Sep 7
TI  - Effectiveness of pharmaceutical therapy of ADHD (Attention-Deficit/Hyperactivity 
      Disorder) in adults - health technology assessment.
PG  - Doc13
LID - 10.3205/hta000091 [doi]
AB  - BACKGROUND: Attention-Deficit/Hyperactivity Disorder (ADHD) is a mental disorder.
      Symptoms include hyperactivity, lack of attentiveness, and frivolousness. This
      disorder always begins in childhood, but can remain through adulthood. ADHD
      affects all areas of life and limits the quality of life due to its symptoms and 
      the high rate of associated disorders that can develop. An established form of
      therapy is using stimulant medications, most commonly, containing Methylphenidate
      as the active ingredient. However, in Germany this ingredient is not approved for
      adults suffering from ADHD. Therefore, many adults cannot obtain appropriate
      medication to treat this disorder. OBJECTIVE: The following report (Health
      Technology Assessment [HTA]) examines the effectiveness and cost-effectiveness of
      the medical treatment of ADHD in adults as well as the ethical, social and legal 
      aspects thereof. METHODS: In August 2009, a systematic literature search is
      performed in all relevant scientific databases. The selected citations fulfill
      predetermined inclusion criteria. The data in the publications is then
      systematically extracted, reviewed and assessed. A manual search of citations is 
      conducted as well. RESULTS: NINETEEN STUDIES FULFILL THE INCLUSION CRITERIA: nine
      randomised controlled studies (RCT), five meta-analyses, three economic studies
      and two studies relevant to the legal aspects of the HTA. All RCT reveal that
      adult patients who receive medication containing a stimulant (Methylphenidate and
      Amphetamine) and Atomoxetine, see a reduction of ADHD symptoms compared to the
      placebo-treated patients. The drug response rate among the control group ranges
      from 7 to 42%; in the treatment group from 17 to 59.6%. The meta-analyses confirm
      the findings of the RCT. In light of the control group, it can be ascertained
      that there are higher annual costs (both direct and indirect) for patients with
      ADHD. The average annual medical expenses for an adult with ADHD were 1,262 $ in 
      1998 and 1,673 $ in 2001 (the converted and inflation-adjusted rate for 2009:
      between 1,270 and 1,619 Euro). The use of stimulants use may impair the patient's
      ability to drive, travel or do sports. No relevant studies can be identified
      concerning the ethical, social and/or legal aspects of stimulant medication for
      ADHD patients. DISCUSSION/CONCLUSION: Medical treatment, particularly including
      Methylphenidate and Atomoxetine, proves to have a positive effect. In order to
      attain an optimal drug response, dosing must be determined on an individual
      basis. There is a need of high-quality studies that directly compare various
      agents - an aspect which is relevant to medical effectiveness of a therapy. No
      definite statement can be made about the cost-effectiveness of the medical
      treatment of ADHD in adults. More health economic studies are therefore required.
      Apart from the unquestionable mental indication, it is already recommended by
      health economic reasons to establish the conditions for an adequate treatment
      with these medicaments also for adults.
FAU - Benkert, Diana
AU  - Benkert D
AD  - CAREM GmbH, Sauerlach, Germany.
FAU - Krause, Klaus-Henning
AU  - Krause KH
FAU - Wasem, Jurgen
AU  - Wasem J
FAU - Aidelsburger, Pamela
AU  - Aidelsburger P
LA  - eng
PT  - Journal Article
DEP - 20100907
PL  - Germany
TA  - GMS Health Technol Assess
JT  - GMS health technology assessment
JID - 101276045
PMC - PMC3010888
OTO - NOTNLM
OT  - ADD
OT  - ADHD
OT  - HTA
OT  - Health Technology Assessment
OT  - add-on therapy
OT  - adult
OT  - adulthood
OT  - adults
OT  - amphetamine
OT  - antidepressive agents
OT  - atomoxetine
OT  - attention deficit disorder
OT  - attention deficit disorder with hyperactivity
OT  - attention deficit hyperactivity disorder
OT  - attention deficit syndrom
OT  - behavior
OT  - behavior disorder
OT  - behavior therapy
OT  - behaviour
OT  - behaviour disorder
OT  - behaviour therapy
OT  - bupropion
OT  - care
OT  - comorbidity
OT  - concentration disorder
OT  - cost analysis
OT  - cost-effectiveness
OT  - costs
OT  - costs and cost analysis
OT  - drug therapy
OT  - drugs
OT  - economics
OT  - efffectiveness
OT  - efficacy
OT  - efficiency
OT  - ethics
OT  - fidgety
OT  - health economics
OT  - hyperactivity syndrom
OT  - hyperactivty
OT  - hyperkinetic disorder
OT  - juridical
OT  - lack of concentration
OT  - learning disability
OT  - medical interventions
OT  - medicaments
OT  - medication therapy
OT  - medicine
OT  - methylphenidate
OT  - minimal cerebral dysfunction
OT  - needed care
OT  - non-stimulants
OT  - noradrenaline reuptake inhibitors
OT  - overactivity
OT  - pharmaceutical therapy
OT  - pharmacotherapy
OT  - psychic
OT  - psychic disorder
OT  - psycho-organic syndrome
OT  - quality of life
OT  - review
OT  - review literature as topic
OT  - ritalin
OT  - social
OT  - stimulant
OT  - stimulants
OT  - stimulants, historical
OT  - striatal frontal dysfunction
OT  - systematic review
OT  - therapy
OT  - treatment
OT  - treatment outcome
OT  - unconcentrated
EDAT- 2011/02/04 06:00
MHDA- 2011/02/04 06:01
CRDT- 2011/02/04 06:00
PHST- 2011/02/04 06:00 [entrez]
PHST- 2011/02/04 06:00 [pubmed]
PHST- 2011/02/04 06:01 [medline]
AID - 10.3205/hta000091 [doi]
PST - epublish
SO  - GMS Health Technol Assess. 2010 Sep 7;6:Doc13. doi: 10.3205/hta000091.


PMID- 21289885
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1861-8863 (Electronic)
IS  - 1861-8863 (Linking)
VI  - 6
DP  - 2010 Sep 1
TI  - The importance of growth factors for the treatment of chronic wounds in the case 
      of diabetic foot ulcers.
PG  - Doc12
LID - 10.3205/hta000090 [doi]
AB  - INTRODUCTION: Ulcers as a result of diabetes mellitus are a serious problem with 
      an enormous impact on the overall global disease burden due to the increasing
      prevalence of diabetes. Because of long hospital stays, rehabilitation, often
      required home care and the use of social services diabetic foot complications are
      costly. Therapy with growth factors could be an effective and innovative add-on
      to standard wound care. RESEARCH QUESTIONS: What is the benefit of therapies with
      growth factors alone or in combination with other technologies in the treatment
      of diabetic foot ulcer assessed regarding medical, economical, social, ethical
      and juridical aspects? METHODS: We systematically searched relevant databases
      limited to English and German language and publications since 1990. Cost values
      were adjusted to the price level of 2008 and converted into Euro. A review and an
      assessment of the quality of publications were conducted following approved
      methodical standards conforming to evidence-based medicine and health economics. 
      RESULTS: We identified 25 studies (14 randomized controlled trials (RCT), nine
      cost-effectiveness analyses, two meta-analyses). The RCT compared an add-on
      therapy to standard wound care with standard wound care/placebo alone or
      extracellular wound matrix: in six studies becaplermin, in two rhEGF, in one
      bFGF, and in five studies the metabolically active skin grafts Dermagraft and
      Apligraf. The study duration ranged from twelve to 20 weeks and the study
      population included between 17 to 382 patients, average 130 patients. The
      treatment with becaplermin, rhEGF and skin implants Dermagraft and Apligraf
      showed in eight out of 13 studies an advantage concerning complete wound closure 
      and the time to complete wound healing. Evidence for a benefit of treatment with 
      bFGF could not be found. In four out of 14 studies the proportion of adverse
      events was 30% per study group with no difference between the treatment groups.
      The methodological quality of the studies was affected by significant
      deficiencies. The results showed becaplermin being cost-effective whereas no
      obvious statement can be made regarding Dermagraft and Apligraf because of
      diverging cost bases and incremental cost-effectiveness ratios. DISCUSSION:
      Differences in standard wound care are complicating the comparison of study
      results. Taking into consideration the small to very small sample sizes and other
      methodological flaws with high potential of bias, the validity of the results
      with regard to effectiveness and cost-effectiveness has to be considered limited.
      The duration of treatment and follow-up examinations is not long enough to assess
      the sustainability of the intervention and the surveillance of ulcer recurrences 
      or treatment related adverse events like the development of malignancy.
      CONCLUSIONS: There are indications of an advantage for the add-on therapy with
      growth factors in diabetic foot ulcers concerning complete wound closure and the 
      time to complete wound healing. Further more studies of high methodological
      quality with adequate sample sizes and sufficient follow-up periods are necessary
      also investigating patient-relevant parameters like the health-related quality of
      life, the acceptance and tolerance of the intervention in addition to clinical
      outcomes.
FAU - Buchberger, Barbara
AU  - Buchberger B
AD  - Institute for Health Care Management and Research, University of Duisburg-Essen, 
      Essen, Germany.
FAU - Follmann, Markus
AU  - Follmann M
FAU - Freyer, Daniela
AU  - Freyer D
FAU - Huppertz, Hendrik
AU  - Huppertz H
FAU - Ehm, Alexandra
AU  - Ehm A
FAU - Wasem, Jurgen
AU  - Wasem J
LA  - eng
PT  - Journal Article
DEP - 20100901
PL  - Germany
TA  - GMS Health Technol Assess
JT  - GMS health technology assessment
JID - 101276045
PMC - PMC3010891
OTO - NOTNLM
OT  - HTA
OT  - Health Technology Assessment
OT  - care
OT  - controlled clinical trials, randomized
OT  - cost-effectiveness
OT  - diabetes
OT  - diabetes mellitus
OT  - diabetes mellitus type 01
OT  - diabetes mellitus type 02
OT  - diabetes mellitus, type 1
OT  - diabetes mellitus, type 2
OT  - diabetes mellitus, type I
OT  - diabetes mellitus, type II
OT  - diabetes related complications
OT  - diabetic foot
OT  - diabetic foot ulcer
OT  - diabetic ulcer
OT  - efficacy
OT  - efficiency
OT  - foot ulcer
OT  - growth factor
OT  - hard healing wound
OT  - health economics
OT  - infection control
OT  - interdisciplinary team
OT  - platelet activating factor
OT  - platelet-derived growth factor
OT  - podology
OT  - random allocation
OT  - recombinant proteins
OT  - review literature as topic
OT  - systematic review
OT  - therapy with growth factors
OT  - wound care
OT  - wound healing
OT  - wound management
EDAT- 2011/02/04 06:00
MHDA- 2011/02/04 06:01
CRDT- 2011/02/04 06:00
PHST- 2011/02/04 06:00 [entrez]
PHST- 2011/02/04 06:00 [pubmed]
PHST- 2011/02/04 06:01 [medline]
AID - 10.3205/hta000090 [doi]
PST - epublish
SO  - GMS Health Technol Assess. 2010 Sep 1;6:Doc12. doi: 10.3205/hta000090.


PMID- 21289884
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1861-8863 (Electronic)
IS  - 1861-8863 (Linking)
VI  - 6
DP  - 2010 Jul 29
TI  - Outpatient pulmonary rehabilitation - rehabilitation models and shortcomings in
      outpatient aftercare.
PG  - Doc11
LID - 10.3205/hta000089 [doi]
AB  - BACKGROUND: The chronic obstructive pulmonary disease (COPD) and the bronchial
      asthma are widespread diseases. They need long-lasting and sustainable
      rehabilitation. OBJECTIVES: The goal of this HTA is to describe the present
      supply and the economic relevance of out-patient pulmonary rehabilitation in
      conjunction with its social aspects. A further target is to derivate options for 
      actions in the health-care system and possible research necessities. METHODS:
      Relevant publications are identified by means of a structured search in 37
      database accessed through the German Institute of Medical Documentation and
      Information (DIMDI). In addition a manual search of identified reference lists
      has been done. The present report includes German and English literature
      published from 2004 to 2009. The methodological quality was assessed by two
      independent researchers according to pre-defined quality criteria of evidence
      based medicine. RESULTS: Among 860 publications 31 medical studies, four economic
      studies and 13 ethical studies meet the inclusion criteria. The studies cover
      rehabilitation programmes in 19 countries. The majority of them has a high level 
      of evidence (1A to 2C). The pulmonary rehabilitation programmes differ by the
      setting (in-patient, out-patient, in-home, community-based), by the length of
      intervention (from two weeks to 36 months), by the way and the frequency of
      intervention and by the duration of the follow-up treatment. Overall out-patient 
      rehabilitation programmes achieve the same positive effects for COPD patients as 
      in-patient programmes do. This is especially true for physical performance and
      health related quality of life. There are only a few studies dealing with asthma.
      Therefore, valid statements cannot be given. The results for cost-effectiveness
      are not distinct enough. DISCUSSION: Goals of pulmonary rehabilitation like
      prevention and adequate treatment of acute exacerbations, the minimisation of
      hospitalisation and the reduction of mortality are attained in out-patient as
      well as in in-patient pulmonary rehabilitation. Regarding the best frequency of
      training units per week or the duration and the content of a unit further
      research is needed. Final results for the ideal length of an in-patient
      rehabilitation are still missing. None of the studies deals with the analysis of 
      the different treatment forms of a COPD which are frequently defined by an
      alteration of in-patient and out-patient treatments and participation in sports
      clubs or self-help groups. There are some other limitations of the studies. The
      results concerning self-management programmes are not distinct. (Self-) Selection
      leads to high drop-out rates. Many studies have only small sample sizes.
      Confounder and long-time effects are seldom researched, relevant economic
      evaluations do not exist The improvement of health related quality of life is
      primarily obtained by an improved disease management than by an improvement of a 
      medical parameter. CONCLUSION: Out-patient pulmonary rehabilitation is as
      effective as in-patient pulmonary rehabilitation. But there is a critical
      shortage of out-patient pulmonary rehabilitation supply in Germany. Domains for
      further research are the evaluation of models for integrated care, the length,
      frequency and content of training programmes, psychiatric assessments and the
      cost-effectiveness of out-patient pulmonary rehabilitation.
FAU - Korczak, Dieter
AU  - Korczak D
AD  - GP-Forschungsgruppe, Institut fur Grundlagen- und Programmforschung, Munich,
      Germany.
FAU - Huber, Beate
AU  - Huber B
FAU - Steinhauser, Gerlinde
AU  - Steinhauser G
FAU - Dietl, Markus
AU  - Dietl M
LA  - eng
PT  - Journal Article
DEP - 20100729
PL  - Germany
TA  - GMS Health Technol Assess
JT  - GMS health technology assessment
JID - 101276045
PMC - PMC3010890
OTO - NOTNLM
OT  - COAD
OT  - COPD
OT  - aeration
OT  - air passages
OT  - airflow obstructions, chronic
OT  - airway obstruction, chronic
OT  - alveolar ventilation
OT  - ambulatory care
OT  - ambulatory care facilities
OT  - ambulatory care facility
OT  - aspiration
OT  - breathing
OT  - care
OT  - chronic airflow obstruction
OT  - chronic airflow obstructions
OT  - chronic airway obstruction
OT  - chronic bronchitis
OT  - chronic obstructive airway disease
OT  - chronic obstructive lung disease
OT  - chronic obstructive pulmonary disease
OT  - cost
OT  - cost-effectiveness
OT  - costs
OT  - effectiveness
OT  - effectiveness, cost
OT  - health care sector
OT  - home care services
OT  - home care services, hospital-based
OT  - home-based
OT  - hospital
OT  - hospital-based
OT  - inpatient
OT  - inpatients
OT  - life qualities
OT  - lung
OT  - managed care program
OT  - managed care programme
OT  - managed care programmes
OT  - managed care programs
OT  - outpatient
OT  - outpatient clinics
OT  - outpatient clinics, hospital
OT  - policlinic
OT  - program effectiveness
OT  - pulmonary emphysema
OT  - quality of life
OT  - rehabilitation
OT  - rehabilitation center
OT  - rehabilitation centers
OT  - rehabilitation centre
OT  - rehabilitation centres
OT  - respiration
OT  - respiratory apparatus
OT  - respiratory disease
OT  - respiratory infection
OT  - respiratory passages
OT  - respiratory system
OT  - respiratory tract
OT  - ventilating
OT  - ventilation
OT  - ventilation disorder
EDAT- 2011/02/04 06:00
MHDA- 2011/02/04 06:01
CRDT- 2011/02/04 06:00
PHST- 2011/02/04 06:00 [entrez]
PHST- 2011/02/04 06:00 [pubmed]
PHST- 2011/02/04 06:01 [medline]
AID - 10.3205/hta000089 [doi]
PST - epublish
SO  - GMS Health Technol Assess. 2010 Jul 29;6:Doc11. doi: 10.3205/hta000089.


PMID- 21289883
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1861-8863 (Electronic)
IS  - 1861-8863 (Linking)
VI  - 6
DP  - 2010 Jul 15
TI  - Prevention of infection after knee arthroplasty.
PG  - Doc10
LID - 10.3205/hta000088 [doi]
AB  - SCIENTIFIC BACKGROUND: Man-made joints (joint endoprostheses), including knee
      endoprostheses, are used in some irreversible diseases of the human joints. The
      implantation of joint endoprostheses (arthroplasty) is associated with an
      increased risk for infection. To prevent infections, different interventions
      without and with the use of antibiotics (hygiene procedures and antibiotic
      prophylaxis) are used. The benefits of these interventions are not clear yet.
      RESEARCH QUESTIONS: The presented report addresses the questions regarding the
      medical effectiveness, the cost-effectiveness as well as the ethical, social and 
      legal aspects related to the use of interventions to prevent infections after
      knee arthroplasty. METHODS: A systematic literature search is conducted in the
      medical electronic databases MEDLINE, EMBASE, SciSearch etc. in June 2009 and has
      been completed by a hand search. The analysis includes publications which
      describe and/or evaluate clinical data from randomized controlled trials (RCT),
      systematic reviews of RCT, registers of endoprostheses or databases concerning
      interventions to prevent infections after knee arthroplasty. The conducted
      literature search also aims to identify health-economic studies and publications 
      dealing explicitly with ethical, social or legal aspects in the use of
      interventions to prevent infections after knee arthroplasty. The synthesis of
      information from different publications has been performed qualitatively.
      RESULTS: The systematic literature search yields 1,030 hits. Based on the
      predefined inclusion and exclusion criteria a total of ten publications is
      included in the analysis. The presented report does not find evidence of the
      effectiveness of different hygiene interventions with a high evidence level. Most
      of the unspecific interventions are recommended on the basis of results from
      non-RCT, from studies for other clinical indications and/or for clinically not
      relevant endpoints, as well as on the basis of expert opinions. The evidence of
      the effectiveness of intravenous prophylaxis with antibiotics in knee
      arthroplasty on a high level of evidence is also missing. The recommendations use
      evidence on the intravenous antibiotic prophylaxis transferred from RCT in hip
      arthroplasty to the arthroplasty of all joints including knee replacement.
      Moreover, no evidence is found for differences in the effectiveness between
      various antibiotics in knee arthroplasty. The presented report finds strong hints
      for the effectiveness of antibiotics in cement in addition to the intravenous
      prophylaxis; however, evidence of the effectiveness may be accepted only for
      operating rooms without clean-air measures. DISCUSSION: The conclusiveness of the
      results from non-RCT and from studies for clinically non-relevant endpoints is
      relatively low. The determined evidence from studies for other clinical
      indications may be generally transferred to knee replacement operations.
      CONCLUSIONS: No proposal to change the recommendations of the Robert Koch
      Institute with respect to hygiene interventions and intravenous antibiotic
      prophylaxis can be made from the presented analysis. Also, no recommendations on 
      the selection of certain antibiotic can be derived from the analysed data. The
      use of antibiotics in cement in addition to the intravenous prophylaxis may be
      generally recommended. The cost-effectiveness of different interventions to
      prevent infections in knee arthroplasty remains unclear. There are no signs for
      concern regarding any ethical, social and/or legal consequences in the use of
      interventions to prevent infections in knee arthroplasty.
FAU - Gorenoi, Vitali
AU  - Gorenoi V
AD  - Institute for Epidemiology, Social Medicine and Health System Research, Hannover 
      Medical School, Hannover, Germany.
FAU - Schonermark, Matthias P
AU  - Schonermark MP
FAU - Hagen, Anja
AU  - Hagen A
LA  - eng
PT  - Journal Article
DEP - 20100715
PL  - Germany
TA  - GMS Health Technol Assess
JT  - GMS health technology assessment
JID - 101276045
PMC - PMC3010886
OTO - NOTNLM
OT  - HTA
OT  - health technology assessment
OT  - knee replacement
OT  - measures for infective protection
OT  - prosthesis-related infections
OT  - systematic review
EDAT- 2011/02/04 06:00
MHDA- 2011/02/04 06:01
CRDT- 2011/02/04 06:00
PHST- 2011/02/04 06:00 [entrez]
PHST- 2011/02/04 06:00 [pubmed]
PHST- 2011/02/04 06:01 [medline]
AID - 10.3205/hta000088 [doi]
PST - epublish
SO  - GMS Health Technol Assess. 2010 Jul 15;6:Doc10. doi: 10.3205/hta000088.


PMID- 21289882
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1861-8863 (Electronic)
IS  - 1861-8863 (Linking)
VI  - 6
DP  - 2010 Jul 5
TI  - Differential diagnostic of the burnout syndrome.
PG  - Doc09
LID - 10.3205/hta000087 [doi]
AB  - INTRODUCTION: There is no consistent definition of burnout. It is neither a
      defined diagnosis in ICD-10 nor in DSM-IV. Yet it is diagnosed by office-based
      doctors and clinicians. Mainly due to reimbursement reasons, diagnoses like
      depression are used instead of burnout diagnoses. Therefore burnout has a very
      high individual, social and economic impact. OBJECTIVES: How is burnout
      diagnosed? Which criteria are relevant? How valid and reliable are the used
      tools?What kind of disorders in case of burnout are relevant for a differential
      diagnosis?What is the economic effect of a differential diagnosis for burnout?Are
      there any negative effects of persons with burnout on patients or clients?Can
      stigmatization of burnout-patients or -clients be observed? METHODS: Based on a
      systematic literature research in 36 databases, studies in English or German
      language, published since 2004, concerning medical and differential diagnoses,
      economic impact and ethical aspects of burnout, are included and evaluated.
      RESULTS: 852 studies are identified. After considering the inclusion and
      exclusion criteria and after reviewing the full texts, 25 medical and one ethical
      study are included. No economic study met the criteria. The key result of this
      report is that so far no standardized, general and international valid procedure 
      exists to obtain a burnout diagnosis. At present, it is up to the physician's
      discretion to diagnose burnout. The overall problem is to measure a phenomenon
      that is not exactly defined. The current available burnout measurements capture a
      three dimensional burnout construct. But the cutoff points do not conform to the 
      standards of scientifically valid test construction. It is important to
      distinguish burnout from depression, alexithymia, feeling unwell and the concept 
      of prolonged exhaustion. An intermittent relation of the constructs is possible. 
      Furthermore, burnout goes along with various ailments like sleep disturbance.
      Through a derogation of work performance it can have also negative effects on
      significant others (for example patients). There is no evidence for
      stigmatization of persons with burnout. DISCUSSION: The evidence of the majority 
      of the studies is predominantly low. Most of the studies are descriptive and
      explorative. Self-assessment tools are mainly used, overall the Maslach Burnout
      Inventory (MBI). Objective data like medical parameters, health status, sick
      notes or judgements by third persons are extremely seldomly included in the
      studies. The sample construction is coincidental in the majority of cases,
      response rates are often low. Almost no longitudinal studies are available. There
      are insufficient results on the stability and the duration of related symptoms.
      The ambiguity of the burnout diagnosis is regularly neglected in the studies.
      CONCLUSIONS: The authors conclude, that (1) further research, particularly
      high-quality studies are needed, to broaden the understanding of the burnout
      syndrome. Equally (2) a definition of the burnout syndrome has to be found which 
      goes beyond the published understanding of burnout and is based on common
      scientific consent. Furthermore, there is a need (3) for finding a standardized, 
      international accepted and valid procedure for the differentiated diagnostics of 
      burnout and for (4) developing a third party assessment tool for the diagnosis of
      burnout. Finally, (5) the economic effects and implication of burnout diagnostics
      on the economy, the health insurances and the patients have to be analysed.
FAU - Korczak, Dieter
AU  - Korczak D
AD  - GP-Forschungsgruppe, Institut fur Grundlagen- und Programmforschung, Munich,
      Germany.
FAU - Huber, Beate
AU  - Huber B
FAU - Kister, Christine
AU  - Kister C
LA  - eng
PT  - Journal Article
DEP - 20100705
PL  - Germany
TA  - GMS Health Technol Assess
JT  - GMS health technology assessment
JID - 101276045
PMC - PMC3010892
OTO - NOTNLM
OT  - ABQ
OT  - Athlete Burnout Questionnaire
OT  - CBI
OT  - Copenhagen Burnout Inventory
OT  - MBI
OT  - Maslach Burnout Inventory
OT  - OLBI
OT  - Oldenburg Burnout Inventory
OT  - SBI
OT  - SMBM
OT  - SMBQ
OT  - School Burnout Inventory
OT  - Shirom Melamed Burnout Measurement
OT  - Shirom Melamed Burnout Questionnaire
OT  - alexithymia
OT  - beat
OT  - burn out outcome
OT  - burn-out
OT  - burn-out categories
OT  - burn-out diagnosis
OT  - burn-out differential diagnosis
OT  - burn-out outcome measure
OT  - burn-out symptoms
OT  - burn-out syndrom
OT  - burn-out victim
OT  - burned out
OT  - burned out categories
OT  - burned out diagnosis
OT  - burned out differential diagnosis
OT  - burned out symptoms
OT  - burning out
OT  - burning out categories
OT  - burning out diagnosis
OT  - burning out differential diagnosis
OT  - burning out symptoms
OT  - burning out victim
OT  - burnout
OT  - burnout categories
OT  - burnout diagnosis
OT  - burnout differential diagnosis
OT  - burnout symptoms
OT  - burnout syndrom
OT  - burnout syndrome
OT  - burnout victim
OT  - categories
OT  - comorbidity
OT  - cut-off
OT  - cutoff
OT  - cynicism
OT  - depersonalisation
OT  - depression
OT  - distress
OT  - drained from working conditions
OT  - efficiency
OT  - exhaustion
OT  - personal efficiency
OT  - predictors
OT  - professional efficiency
OT  - screening
OT  - state of exhaustion
EDAT- 2011/02/04 06:00
MHDA- 2011/02/04 06:01
CRDT- 2011/02/04 06:00
PHST- 2011/02/04 06:00 [entrez]
PHST- 2011/02/04 06:00 [pubmed]
PHST- 2011/02/04 06:01 [medline]
AID - 10.3205/hta000087 [doi]
PST - epublish
SO  - GMS Health Technol Assess. 2010 Jul 5;6:Doc09. doi: 10.3205/hta000087.


PMID- 21289881
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1861-8863 (Electronic)
IS  - 1861-8863 (Linking)
VI  - 6
DP  - 2010 Jun 14
TI  - Invasive home mechanical ventilation, mainly focused on neuromuscular disorders.
PG  - Doc08
LID - 10.3205/hta000086 [doi]
AB  - INTRODUCTION AND BACKGROUND: Invasive home mechanical ventilation is used for
      patients with chronic respiratory insufficiency. This elaborate and
      technology-dependent ventilation is carried out via an artificial airway
      (tracheal cannula) to the trachea. Exact numbers about the incidence of home
      mechanical ventilation are not available. Patients with neuromuscular diseases
      represent a large portion of it. RESEARCH QUESTIONS: Specific research questions 
      are formulated and answered concerning the dimensions of medicine/nursing,
      economics, social, ethical and legal aspects. Beyond the technical aspect of the 
      invasive home, mechanical ventilation, medical questions also deal with the
      patient's symptoms and clinical signs as well as the frequency of complications. 
      Economic questions pertain to the composition of costs and the differences to
      other ways of homecare concerning costs and quality of care. Questions regarding 
      social aspects consider the health-related quality of life of patients and
      caregivers. Additionally, the ethical aspects connected to the decision of home
      mechanical ventilation are viewed. Finally, legal aspects of financing invasive
      home mechanical ventilation are discussed. METHODS: Based on a systematic
      literature search in 2008 in a total of 31 relevant databases current literature 
      is viewed and selected by means of fixed criteria. Randomized controlled studies,
      systematic reviews and HTA reports (health technology assessment), clinical
      studies with patient numbers above ten, health-economic evaluations, primary
      studies with particular cost analyses and quality-of-life studies related to the 
      research questions are included in the analysis. RESULTS AND DISCUSSION: Invasive
      mechanical ventilation may improve symptoms of hypoventilation, as the analysis
      of the literature shows. An increase in life expectancy is likely, but for
      ethical reasons it is not confirmed by premium-quality studies. Complications (e.
      g. pneumonia) are rare. Mobile home ventilators are available for the
      implementation of the ventilation. Their technical performance however, differs
      regrettably. Studies comparing the economic aspects of ventilation in a hospital 
      to outpatient ventilation, describe home ventilation as a more cost-effective
      alternative to in-patient care in an intensive care unit, however, more expensive
      in comparison to a noninvasive (via mask) ventilation. Higher expenses arise due 
      to the necessary equipment and the high expenditure of time for the partial
      24-hour care of the affected patients through highly qualified personnel.
      However, none of the studies applies to the German provisionary conditions. The
      calculated costs strongly depend on national medical fees and wages of
      caregivers, which barely allows a transmission of the results. The results of
      quality-of-life studies are mostly qualitative. The patient's quality of life
      using mechanical ventilation is predominantly considered well. Caregivers of
      ventilated patients report positive as well as negative ratings. Regarding the
      ethical questions, it was researched which aspects of ventilation implementation 
      will have to be considered. From a legal point of view the financing of home
      ventilation, especially invasive mechanical ventilation, requiring specialised
      technical nursing is regulated in the code of social law (Sozialgesetzbuch V).
      The absorption of costs is distributed to different insurance carriers, who
      often, due to cost pressures within the health care system, insurance carriers,
      who consider others and not themselves as responsible. Therefore in practice, the
      necessity to enforce a claim of cost absorption often arises in order to exercise
      the basic right of free choice of location. CONCLUSION: Positive effects of the
      invasive mechanical ventilation (overall survival and symptomatic) are highly
      probable based on the analysed literature, although with a low level of evidence.
      An establishment of a home ventilation registry and health care research to
      ascertain valid data to improve outpatient structures is necessary. Gathering
      specific German data is needed to adequately depict the national concepts of
      provision and reimbursement. A differentiation of the cost structure according to
      the type of chosen outpatient care is currently not possible. There is no
      existing literature concerning the difference of life quality depending on the
      chosen outpatient care (homecare, assisted living, or in a nursing home
      specialised in invasive home ventilation). Further research is required. For a so
      called participative decision - made by the patient after intense counselling -
      an early and honest patient education pro respectively contra invasive mechanical
      ventilation is needed. Besides the long term survival, the quality of life and
      individual, social and religious aspects have also to be considered.
FAU - Geiseler, Jens
AU  - Geiseler J
AD  - Centre of pneumology and thoracic surgery, Asklepios Hospital Gauting, Department
      of intensive-care medicine and long-term ventilation, Gauting, Germany.
FAU - Karg, Ortrud
AU  - Karg O
FAU - Borger, Sandra
AU  - Borger S
FAU - Becker, Kurt
AU  - Becker K
FAU - Zimolong, Andreas
AU  - Zimolong A
LA  - eng
PT  - Journal Article
DEP - 20100614
PL  - Germany
TA  - GMS Health Technol Assess
JT  - GMS health technology assessment
JID - 101276045
PMC - PMC3010883
OTO - NOTNLM
OT  - HTA
OT  - Health Technology Assessment
OT  - economic analysis
OT  - ethics
OT  - extra-clinical ventilation
OT  - health related quality of life
OT  - home ventilation
OT  - invasive ventilation
OT  - mechanical ventilation
OT  - neuromuscular disease
OT  - psychologic pressure
OT  - quality of life
OT  - respiratory insufficience
OT  - vital capacity
EDAT- 2011/02/04 06:00
MHDA- 2011/02/04 06:01
CRDT- 2011/02/04 06:00
PHST- 2011/02/04 06:00 [entrez]
PHST- 2011/02/04 06:00 [pubmed]
PHST- 2011/02/04 06:01 [medline]
AID - 10.3205/hta000086 [doi]
PST - epublish
SO  - GMS Health Technol Assess. 2010 Jun 14;6:Doc08. doi: 10.3205/hta000086.


PMID- 21289879
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1861-8863 (Electronic)
IS  - 1861-8863 (Linking)
VI  - 6
DP  - 2010 Apr 27
TI  - Dental indications for the instrumental functional analysis in additional
      consideration of health-economic aspects.
PG  - Doc06
LID - 10.3205/hta000084 [doi]
AB  - BACKGROUND: Besides clinical and radiological examination instrumental functional
      analyses are performed as diagnostic procedures for craniomandibular
      dysfunctions. Instrumental functional analyses cause substantial costs and shows 
      a considerable variability between individual dentist practices. OBJECTIVES: On
      the basis of published scientific evidence the validity of the instrumental
      functional analysis for the diagnosis of craniomandibular dysfunctions compared
      to clinical diagnostic procedures; the difference of the various forms of the
      instrumental functional analysis; the existence of a dependency on additional
      other factors and the need for further research are determined in this report. In
      addition, the cost effectiveness of the instrumental functional analysis is
      analysed in a health-policy context, and social, legal and ethical aspects are
      considered. METHODS: A literature search is performed in over 27 databases and by
      hand. Relevant companies and institutions are contacted concerning unpublished
      studies. The inclusion criteria for publications are (i) diagnostic studies with 
      the indication "craniomandibular malfunction", (ii) a comparison between clinical
      and instrumental functional analysis, (iii) publications since 1990, (iv)
      publications in English or German. The identified literature is evaluated by two 
      scientists regarding the relevance of content and methodical quality. RESULTS:
      The systematic database search resulted in 962 hits. 187 medical and economic
      complete publications are evaluated. Since the evaluated studies are not relevant
      enough to answer the medical or health economic questions no study is included.
      DISCUSSION: The inconsistent terminology concerning craniomandibular dysfunctions
      and instrumental functional analyses results in a broad literature search in
      databases and an extensive search by hand. Since no relevant results concerning
      the validity of the instrumental functional analysis in comparison to the
      clinical functional analysis are found, it is impossible to make relevant
      statements concerning the underlying research questions. CONCLUSION: Studies
      comparing the instrumental functional analysis to the clinical functional
      analysis for the diagnosis of craniomandibular dysfunctions are missing. So far
      the instrumental functional analysis is not systematically and independently
      validated in comparison to the clinical functional analysis as the reference
      standard. It is uncertain, whether conducting an instrumental functional analysis
      with a clinical functional analysis for the diagnostics of craniomandibular
      dysfunctions is recommendable. Further research is strongly recommended.
FAU - Tinnemann, Peter
AU  - Tinnemann P
AD  - Institute for Social Medicine, Epidemiology and Health Economics, Charite -
      Universitatsmedizin, Berlin, Germany.
FAU - Stober, Yvonne
AU  - Stober Y
FAU - Roll, Stephanie
AU  - Roll S
FAU - Vauth, Christoph
AU  - Vauth C
FAU - Willich, Stefan N
AU  - Willich SN
FAU - Greiner, Wolfgang
AU  - Greiner W
LA  - eng
PT  - Journal Article
DEP - 20100427
PL  - Germany
TA  - GMS Health Technol Assess
JT  - GMS health technology assessment
JID - 101276045
PMC - PMC3010889
OTO - NOTNLM
OT  - clinical functional analysis
OT  - cost-effectiveness
OT  - craniomandibular dysfunction
OT  - dentistry
OT  - dentofacial
OT  - diagnosis
OT  - functional analysis
OT  - health economics
OT  - instrumental functional analysis
OT  - instruments
OT  - jawborne
OT  - mandibular joint
OT  - mouth
OT  - odontology
OT  - oral medicine
OT  - orthodontics
EDAT- 2011/02/04 06:00
MHDA- 2011/02/04 06:01
CRDT- 2011/02/04 06:00
PHST- 2011/02/04 06:00 [entrez]
PHST- 2011/02/04 06:00 [pubmed]
PHST- 2011/02/04 06:01 [medline]
AID - 10.3205/hta000084 [doi]
PST - epublish
SO  - GMS Health Technol Assess. 2010 Apr 27;6:Doc06. doi: 10.3205/hta000084.


PMID- 21289877
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1861-8863 (Electronic)
IS  - 1861-8863 (Linking)
VI  - 6
DP  - 2010 Mar 16
TI  - Medical and health economic evaluation of prevention- and control measures
      related to MRSA infections or -colonisations at hospitals.
PG  - Doc04
LID - 10.3205/hta000082 [doi]
AB  - INTRODUCTION: Methicillin-resistant Staphylococcus aureus (MRSA) are dangerous
      agents of nosocomial infections. In 2007 the prevalence of MRSA is 20.3% in
      Germany (Oxacilline-resistance according to EUCAST-criteria [EUCAST = European
      Committee on Antimicrobial Susceptibility Testing]). OBJECTIVES: Which
      measurements are effective in the prevention and control of MRSA-infections in
      the hospital?How effective are contact precautions, screening, decolonisation,
      education and surveillance?Which recommendations can be given to health care
      politics on the basis of cost-effectiveness studies?Have there been any adverse
      effects on patients and clinical staff?What kind of liability problems exist?
      METHODS: Based on a systematic review of the literature studies are included
      which have been published in German or English language since 2004. RESULTS:
      1,508 articles have been found. After having surveyed the full text, 33 medical, 
      eight economic and four ethical/juridical studies are included for the Health
      Technology Assessment (HTA) report. The key result of the HTA report is that
      different measurements are effective in the prevention and control of
      MRSA-infections in hospitals, though the majority of the studies has a low
      quality. Effective are the conduction of differentiated screening measurements if
      they take into account the specific endemic situation, the use of
      antibiotic-control programs and the introduction and control of hygienic
      measurements. The break even point of preventive and control measurements cannot 
      be defined because the study results differ too much. In the future it has to be 
      more considered that MRSA-infections and contact precautions lead to a
      psycho-social strain for patients. DISCUSSION: It is hardly possible to describe 
      causal efficacies because in the majority of the studies confounders are not
      sufficiently considered. In many cases bundles of measurements have been
      established but not analyzed individually. The internal and external validity of 
      the studies is too weak to evaluate single interventions. Hygienic measurements
      prove to be effective in combination with other measurements. But it cannot be
      said which of the single measurements (gloves, washing hands, wearing gowns or
      masks) has the strongest effect on the reduction of MRSA. It is irritating that
      there are high differences in the compliance concerning hand hygiene between
      different studies. A general decolonisation is questionable for different
      reasons: first because of the side-effects for patients, second because of the
      high rate of spontaneous remissions in the untreated control group, third because
      of the differentiated process from colonisation to infection. Severalfold
      Hawthorne effects have been reported. One of them is that the competition between
      hospitals to reduce MRSA-rates leads already to a reduction. CONCLUSIONS: It is
      evident that selective screening programs of risk patients considering the
      particular MRSA-prevalence are of use. The application of rapid tests seems to be
      only recommendable for risk patients and a high MRSA-prevalence. The improvement 
      of the compliance of hand hygiene should be the basis of any prevention strategy.
      Training of staff members (with feedback mechanisms) is effective to improve
      compliance and to optimise the use of antibiotics. Antibiotic management programs
      are effective as well. Obviously multimodal approaches can lead to overadditive
      effects. Therefore the catalogue of preventive and control measurements has to be
      further evaluated. Good cost-efficacy studies are missing in Germany. The
      psychosocial effects of MRSA-infections are not researched in Germany. There is
      only punctual information on the risk management of hospitals.
FAU - Korczak, Dieter
AU  - Korczak D
AD  - GP-Forschungsgruppe, Institut fur Grundlagen- und Programmforschung, Munich,
      Germany.
FAU - Schoffmann, Christine
AU  - Schoffmann C
LA  - eng
PT  - Journal Article
DEP - 20100316
PL  - Germany
TA  - GMS Health Technol Assess
JT  - GMS health technology assessment
JID - 101276045
PMC - PMC3010887
OTO - NOTNLM
OT  - HaMRSA
OT  - MRSA
OT  - MRSA colonization/colonisation
OT  - MRSA infection
OT  - Methicillin resistance
OT  - Methicillin resistant Staphylococcus aureus
OT  - ORSA
OT  - Oxacillin resistant Staphylococcus aureus
OT  - Staphylococcus
OT  - Staphylococcus aureus
OT  - antibiotic
OT  - control
OT  - cost
OT  - cost analysis
OT  - cost effectiveness
OT  - cost-benefit-analysis
OT  - decolonisation
OT  - decontamination
OT  - economics
OT  - education
OT  - eradication
OT  - hand hygiene
OT  - handwashing
OT  - healthcare-associated MRSA
OT  - hospital
OT  - hospital-acquired MRSA
OT  - infection-control
OT  - isolation
OT  - nosocomial infection
OT  - patient
OT  - precautions
OT  - prevention
OT  - preventive measures
OT  - screening
OT  - staff
OT  - surveillance
OT  - training
OT  - treatment
EDAT- 2011/02/04 06:00
MHDA- 2011/02/04 06:01
CRDT- 2011/02/04 06:00
PHST- 2011/02/04 06:00 [entrez]
PHST- 2011/02/04 06:00 [pubmed]
PHST- 2011/02/04 06:01 [medline]
AID - 10.3205/hta000082 [doi]
PST - epublish
SO  - GMS Health Technol Assess. 2010 Mar 16;6:Doc04. doi: 10.3205/hta000082.


PMID- 21289876
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20220409
IS  - 1861-8863 (Electronic)
IS  - 1861-8863 (Linking)
VI  - 6
DP  - 2010 Mar 16
TI  - New-onset diabetes and antihypertensive treatment.
PG  - Doc03
LID - 10.3205/hta000081 [doi]
AB  - INTRODUCTION: Chronic diseases substantially contribute to the continuous
      increase in health care expenditures, including type-2 diabetes mellitus as one
      of the most expensive chronic diseases. Arterial hypertension presents a risk
      factor for the development of type-2 diabetes mellitus. Numerous analyses have
      demonstrated that antihypertensive therapies promote the development of
      type-2-diabetes mellitus. Studies indicate, that the application of angiotensin
      converting enzyme (ACE) inhibitors and angiotensin-receptor-blockers (ARB) lead
      to less new-onset diabetes compared to beta-blockers, diuretics and placebo.
      Given that beta-blockers and diuretics impair the glucose metabolism, the
      metabolic effects of different antihypertensive drugs should be regarded;
      otherwise not only the disease itself, but also antihypertensive therapies may
      promote the development of new-onset diabetes. Even though, the cost of ACE
      inhibitors and ARB are higher, the use in patients with metabolic disorders could
      be cost-effective in the long-term if new-onset diabetes is avoided. OBJECTIVES: 
      To evaluate which class of antihypertensive agents promote the development or the
      manifestation of type-2 diabetes mellitus. How high is the incidence of new-onset
      diabetes during antihypertensive therapy and how is treatment-induced type-2
      diabetes mellitus evaluated clinically? Which agents are therefore cost-effective
      in the long term? Which ethical, social or legal aspects should be regarded?
      METHODS: A systematic literature review was conducted including clinical trials
      with at least ten participants which reported new-onset diabetes in the course of
      antihypertensive treatment. The trials had to be published after 1966 (after 2003
      for economic publications) in English or German. RESULTS: A total of 34 clinical 
      publications meet the inclusion criteria. Of these, eight publications focus on
      the development of diabetes mellitus under treatment with diuretic and/or
      beta-blockers, six publications focused on ACE inhibitors alone or in combination
      with calcium-channel-blockers, ten publications on ARB and/or ACE inhibitors with
      respect to their effects on new-onset diabetes or their preventive aspects.
      Furthermore, five publications investigate the role of
      calcium-channel-antagonists in the development of diabetes, and five publications
      indicate the development of new-onset diabetes with different antihypertensive
      agents amongst each other or in comparison to no antihypertensive treatment. The 
      clinical trials show a significant difference in the development of new-onset
      diabetes. Therapies with diuretics and/or beta-blockers result in a higher
      incidence of new-onset diabetes. ARB as well as ACE inhibitors have a preventive 
      effect and calcium-channel-blockers show a neutral position regarding the
      development of new-onset diabetes. Two publications report on economic results.
      The first one evaluates the cost-effectiveness of ARB alone or in combination
      with calcium-channel-blockers in comparison to diuretics alone or in combination 
      with beta-blockers. The second publication compares economic outcomes of
      calcium-channel-blockers and beta-blockers considering the development of
      new-onset diabetes. Treatment with the ARB candesartan lead to savings in total
      costs of 549 US-Dollar per patient and in incremental costs of 30,000 US-Dollar
      per diabetes mellitus avoided. In the second publication, costs to the amount of 
      18,965 Euro in Great Britain and 13,210 Euro in Sweden are quoted for an avoided 
      event. The treatment with calcium-channel-blockers compared to beta-blockers is
      proven to be more cost-effective. No publications were identified regarding
      ethical, social and legal aspects. DISCUSSION: The available meta-analyses allow 
      for a high clinical evidence level. A few studies vary in terms of diabetes
      definition and study duration. In most of the trials, the incidence of new-onset 
      diabetes is not an endpoint. The evaluation of treatment-induced diabetes
      mellitus cannot be conducted, due to the lack of sufficient results in the
      identified literature. The two economic studies do not address all the objectives
      sufficiently. Ethical, social and legal aspects are discussed but not analysed
      systematically. CONCLUSION: Based on these studies, sufficient evidence to
      confirm the presumption that diuretics and/or beta-blockers promote the
      development of new-onset diabetes compared to other antihypertensive agents,
      especially in patients who are predisposed, is presented with this report. Trials
      reflecting the clinical relevance of treatment-induced diabetes mellitus compared
      to existing diabetes mellitus regarding cardiovascular outcomes are required.
      Also health economic evaluations considering the development of new-onset
      diabetes should be conducted for the different classes of antihypertensive
      agents.
FAU - Grimm, Christine
AU  - Grimm C
AD  - Institute of Empirical Health Economics, Burscheid, Germany.
FAU - Koberlein, Juliane
AU  - Koberlein J
FAU - Wiosna, Waldemar
AU  - Wiosna W
FAU - Kresimon, Jutta
AU  - Kresimon J
FAU - Kiencke, Peter
AU  - Kiencke P
FAU - Rychlik, Reinhard
AU  - Rychlik R
LA  - eng
PT  - Journal Article
DEP - 20100316
PL  - Germany
TA  - GMS Health Technol Assess
JT  - GMS health technology assessment
JID - 101276045
PMC - PMC3010880
OTO - NOTNLM
OT  - Angiotensin II type receptor blockers
OT  - Angiotensin-converting enzyme inhibitors
OT  - calcium channel blockers
OT  - diabetes mellitus, type 2
OT  - diuretics
OT  - hypertension
EDAT- 2011/02/04 06:00
MHDA- 2011/02/04 06:01
CRDT- 2011/02/04 06:00
PHST- 2011/02/04 06:00 [entrez]
PHST- 2011/02/04 06:00 [pubmed]
PHST- 2011/02/04 06:01 [medline]
AID - 10.3205/hta000081 [doi]
PST - epublish
SO  - GMS Health Technol Assess. 2010 Mar 16;6:Doc03. doi: 10.3205/hta000081.


PMID- 21289875
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1861-8863 (Electronic)
IS  - 1861-8863 (Linking)
VI  - 6
DP  - 2010 Mar 16
TI  - The impact of microsurgery, stereotactic radiosurgery and radiotherapy in the
      treatment of meningiomas depending on different localizations.
PG  - Doc02
LID - 10.3205/hta000080 [doi]
AB  - SCIENTIFIC BACKGROUND: Meningiomas are the most common benign intracranial
      neoplasms with a slow growth presented as the intracranial lesion. These tumors
      are without any symptoms for a long time. At the time of diagnosis it is
      frequently an asymptomatic tumor. In that case the therapist may well suggest a
      wait-and-see strategy. The therapy of meningiomas focuses firstly on the
      microsurgical treatment. Volume reduction can be achieved immediately after
      treatment. Stereotactic radiosurgery is an important non-invasive treatment
      option for recurrent tumors or meningiomas with partial resection. The technical 
      equipment for the stereotactic radiosurgery is a cost intensive investment. In
      this context the high precision of the intervention, presented as a low
      invasiveness of the treatment, is an important factor. The aim of this assessment
      is to identify the chances and limitations of the diverse treatment options and
      to estimate their outcome for different localisations of meningiomas. METHODS: In
      December 2007 a systematic literature search was conducted using the most
      relevant medical databases. The whole strategy and the used search terms were
      documented. The literature search was supplemented with an internet and
      literature based hand search on law, ethics and economics. Primary studies and
      systematic reviews which report relevant outcomes are included in this analysis. 
      The current assessment is based on the available evidence that was found at the
      time of the literature search. RESULTS: A total of 31 publications for the
      medical focus of assessment and three reports from the economical hand search
      were included. In general, it is not possible to identify neither randomised
      clinical trials or prospective, contrasting cohort studies nor studies
      summarising results from such studies. The results presented in the literature
      published by surgeons strongly vary regarding localisation of meningiomas.
      Publications not differentiating between the localisation of meningiomas indicate
      a progression free survival rate of five years in 77 to 97% of the cases after
      complete surgical resection of the tumor, in 18 to 70% of the cases after
      subtotal resection and for patients who had undergone surgical resection and a
      combined radiotherapeutical treatment of their meningiomas a five year
      progression free survival rate between 82 and 97%. Other treatment options like
      hormone therapy or treatments to stop tumor growth had been used unsuccessfully
      so far. Based on the results presented regarding economic evaluation, costs
      resulting from radiosurgical treatment are lower in contrast to costs resulting
      from surgical resection. However, it has to be taken into account that costs
      resulting from radiosurgical treatment strongly depend on the number of patients 
      treated in total with the radiosurgical equipment. CONCLUSION: Due to the strong 
      dependencies between the results from surgical therapy and the localisation of
      the tumor, it is only possible to derive recommendations on whether or not to
      perform the surgical therapy with respect to the localisation of the tumor. Only 
      for patients with tumors with a spinal localisation or WHO Grade I meningiomas
      with a cortical localisation, primary treatment with by means of microsurgery can
      be suggested. For all other localisations of the tumor, alternative treatment by 
      radiosurgery should be discussed. From the literature identified, a clear
      recommendation of one or the other therapy however can not be deduced. Thus,
      there is a strong need for randomised clinical trials or prospective or
      contrasting cohort studies, which compare rigorously microsurgery with
      radiosurgery concerning different localisations of tumors.
FAU - Schmieder, Kirsten
AU  - Schmieder K
AD  - Department of Neurosurgery, Medical Faculty Mannheim, Germany.
FAU - Engelhardt, Martin
AU  - Engelhardt M
FAU - Wawrzyniak, Sebastian
AU  - Wawrzyniak S
FAU - Borger, Sandra
AU  - Borger S
FAU - Becker, Kurt
AU  - Becker K
FAU - Zimolong, Andreas
AU  - Zimolong A
LA  - eng
PT  - Journal Article
DEP - 20100316
PL  - Germany
TA  - GMS Health Technol Assess
JT  - GMS health technology assessment
JID - 101276045
PMC - PMC3010884
OTO - NOTNLM
OT  - biomedical technology
OT  - meningeal neoplasms
OT  - meningioma
OT  - microsurgerygamma knife radiosurgery
OT  - neurosurgery
OT  - radiosurgery
OT  - radiosurgery gamma knife
OT  - radiosurgery, linac
OT  - radiosurgery, linear accelerator
OT  - review literature
OT  - review, systematic
OT  - spinal cord neoplasms
OT  - stereotaxic technique
OT  - technology assessment, biomedical
EDAT- 2011/02/04 06:00
MHDA- 2011/02/04 06:01
CRDT- 2011/02/04 06:00
PHST- 2011/02/04 06:00 [entrez]
PHST- 2011/02/04 06:00 [pubmed]
PHST- 2011/02/04 06:01 [medline]
AID - 10.3205/hta000080 [doi]
PST - epublish
SO  - GMS Health Technol Assess. 2010 Mar 16;6:Doc02. doi: 10.3205/hta000080.


PMID- 21289874
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1861-8863 (Electronic)
IS  - 1861-8863 (Linking)
VI  - 6
DP  - 2010 Mar 16
TI  - Specific immunotherapy (SIT) in the treatment of allergic rhinitis.
PG  - Doc01
LID - 10.3205/hta000079 [doi]
AB  - SCIENTIFIC BACKGROUND: Allergic rhinitis (AR) exhibits a prevalence of approx.
      20% in Germany and causes enormous costs in the health care system. Specific
      immunotherapy (SIT) is considered to be the only potentially causal therapy for
      AR and mainly administered by two routes, subcutaneous (SCIT) and sublinguale
      (SLIT). SIT promises a reduction of symptoms and the need for medication in
      patients with AR. RESEARCH QUESTIONS: The question arises, to what extent is SIT 
      effective and cost effective in the treatment of AR and which ethical-social and 
      legal aspects have to be considered regarding its application. METHODS: The
      literature search was accomplished in the electronic data bases MEDLINE, EMBASE
      etc. in February 2008. The medical evaluation was based on systematic reviews of 
      blinded, randomised controlled studies (RCT). The economic evaluation included
      health-economic studies on the basis of RCT. Additionally, it was also searched
      for publications explicitly addressing ethical-social and legal aspects of the
      use of SIT. RESULTS: MEDICAL EVALUATION: Two reviews on SCIT and three on SLIT
      were included in the medical evaluation. For the evaluation of SIT with grass
      pollen results for short and medium-term effects are considered from several
      studies, for SIT with other seasonal allergens (e. g. tree pollen) and with house
      dust mite allergens from clearly fewer studies and for SIT with other perennial
      allergens only from a few. The reviews report a significant reduction of the
      symptom and medication score in favour of SCIT with seasonal allergens and
      recognise the effectiveness at least for grass pollen allergens. Also for other
      seasonal allergens SCIT is appraised as effective. The reviews about SLIT
      determine a significant reduction of the symptom and the medication score in
      favour of SLIT vs. placebo in short and medium term follow-up in evaluations
      across all allergens. The subgroup analyses show a significant reduction of the
      symptom and medication score only in favour of SLIT with seasonal allergens.
      HEALTH ECONOMIC EVALUATION: Four publications about two health economic studies
      are identified, one of these publications on Alutard-SQ((R)) injections (SCIT)
      and three on GRAZAX((R)) tablets (SLIT). The studies provide more (on
      Alutard-SQ((R))) or less (on GRAZAX((R))) robust information, but no evidence on 
      cost effectiveness of these SIT administration forms in patients with AR.
      DISCUSSION: The topic of the report is very broad, so that the evidence is
      summarised using systematic reviews. In particular the statistic heterogeneity of
      the studies found in the reviews considerably limits the strength of the
      findings. The included health economic studies show different methodical flaws,
      the largest potential bias is the projection of the magnitude of the medium-term 
      clinical effects on the time period of nine years. CONCLUSIONS: The effectiveness
      of SIT in patients with AR is not equally proven for all SIT administration forms
      and allergens. For SCIT and SLIT with grass pollen allergens short and
      medium-term effectiveness can be regarded as proven. These therapy forms should
      be used if the indication is appropriate and if no contraindications are present.
      Also SCIT and SLIT with other seasonal allergens such as tree pollen allergens
      can be an effective treatment option, but used with a certain restraint due to
      insufficient data especially in the case of SLIT. For SIT with house dust mite
      allergens and further perennial allergens no consistent proof of effectiveness
      are to be determined from the available information. Further research addressing 
      non-grass pollen-associated SIT, allergen and manufacturer specific evaluations
      as well as asthma prevention is needed. Due to the lack of evidence the use of
      SIT can not be seen proven as cost effective. To provide such evidence further
      health economic studies with a long term follow-up are needed. The informed
      consent of the patients is an important ethical requirement within the use of
      SIT.
FAU - Hagen, Anja
AU  - Hagen A
AD  - Institute for Epidemiology, Public Medicine and Healthcare Systems Research,
      Hannover Medical School, Hannover, Germany.
FAU - Gorenoi, Vitali
AU  - Gorenoi V
FAU - Schonermark, Matthias P
AU  - Schonermark MP
LA  - eng
PT  - Journal Article
DEP - 20100316
PL  - Germany
TA  - GMS Health Technol Assess
JT  - GMS health technology assessment
JID - 101276045
PMC - PMC3010882
OTO - NOTNLM
OT  - desensitization, immunologic
OT  - immunotherapy
OT  - review
OT  - rhinitis, allergic, perennial
OT  - rhinitis, allergic, seasonal
EDAT- 2011/02/04 06:00
MHDA- 2011/02/04 06:01
CRDT- 2011/02/04 06:00
PHST- 2011/02/04 06:00 [entrez]
PHST- 2011/02/04 06:00 [pubmed]
PHST- 2011/02/04 06:01 [medline]
AID - 10.3205/hta000079 [doi]
PST - epublish
SO  - GMS Health Technol Assess. 2010 Mar 16;6:Doc01. doi: 10.3205/hta000079.


PMID- 21287892
OWN - NLM
STAT- MEDLINE
DCOM- 20110324
LR  - 20190608
IS  - 0027-9684 (Print)
IS  - 0027-9684 (Linking)
VI  - 102
IP  - 12
DP  - 2010 Dec
TI  - Pilot assessment of HIV gene therapy-hematopoietic stem cell clinical trial
      acceptability among minority patients and their advisors.
PG  - 1123-8
AB  - Clinical trials involving technologically involved novel treatments such as gene 
      therapy delivered through hematopoietic stem cells as human immunodeficiency
      virus (HIV) treatment will need to recruit ethnically diverse patients to ensure 
      the acceptance among broad groups of individuals and generalizability of research
      findings. Five focus groups of 47 HIV-positive men and women, religious and
      community leaders and health providers, mostly from African American and
      low-income communities, were conducted to examine knowledge about gene therapy
      and stem cell research and to assess the moral and ethical beliefs that might
      influence participation in clinical trials. Three themes emerged from these
      groups: (1) the need for clarification of terminology and the ethics of
      understanding gene therapy-stem cell research, (2) strategies to avoid mistrust
      of medical procedures and provider mistrust, and (3) the conflict between science
      and religious beliefs as it pertains to gene therapy-stem cell research.
FAU - King, William Douglas
AU  - King WD
AD  - Semel Institute for Neuroscience and Human Behavior, University of California,
      Los Angeles, USA.
FAU - Wyatt, Gail E
AU  - Wyatt GE
FAU - Liu, Honghu
AU  - Liu H
FAU - Williams, John K
AU  - Williams JK
FAU - DiNardo, Anthony D
AU  - DiNardo AD
FAU - Mitsuyasu, Ronald T
AU  - Mitsuyasu RT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Natl Med Assoc
JT  - Journal of the National Medical Association
JID - 7503090
SB  - IM
MH  - Adult
MH  - *Clinical Trials as Topic/ethics
MH  - Female
MH  - Focus Groups
MH  - *Genetic Therapy/ethics
MH  - HIV Infections/*ethnology/*therapy
MH  - *Health Knowledge, Attitudes, Practice
MH  - *Hematopoietic Stem Cell Transplantation/ethics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Minority Groups
MH  - Morals
MH  - Pilot Projects
MH  - Treatment Outcome
EDAT- 2011/02/04 06:00
MHDA- 2011/03/25 06:00
CRDT- 2011/02/04 06:00
PHST- 2011/02/04 06:00 [entrez]
PHST- 2011/02/04 06:00 [pubmed]
PHST- 2011/03/25 06:00 [medline]
AID - S0027-9684(15)30766-5 [pii]
AID - 10.1016/s0027-9684(15)30766-5 [doi]
PST - ppublish
SO  - J Natl Med Assoc. 2010 Dec;102(12):1123-8. doi: 10.1016/s0027-9684(15)30766-5.


PMID- 21286320
OWN - NLM
STAT- MEDLINE
DCOM- 20110314
LR  - 20211020
IS  - 0008-5286 (Print)
IS  - 0008-5286 (Linking)
VI  - 51
IP  - 11
DP  - 2010 Nov
TI  - Veterinary medical ethics. An ethicist's commentary on castration of cats
      on-farm.
PG  - 1956, 1198
FAU - Rollin, Bernard E
AU  - Rollin BE
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Vet J
JT  - The Canadian veterinary journal = La revue veterinaire canadienne
JID - 0004653
SB  - IM
MH  - Analgesia/methods/veterinary
MH  - Animal Welfare/ethics
MH  - Animals
MH  - Canada
MH  - Cats/*surgery
MH  - *Ethics, Professional
MH  - Legislation, Veterinary
MH  - Male
MH  - Orchiectomy/ethics/methods/*veterinary
MH  - Pain/prevention & control/*veterinary
MH  - Veterinary Medicine/*ethics
PMC - PMC2957026
EDAT- 2011/02/03 06:00
MHDA- 2011/03/15 06:00
CRDT- 2011/02/03 06:00
PHST- 2011/02/03 06:00 [entrez]
PHST- 2011/02/03 06:00 [pubmed]
PHST- 2011/03/15 06:00 [medline]
PST - ppublish
SO  - Can Vet J. 2010 Nov;51(11):1956, 1198.


PMID- 21283530
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1662-5153 (Electronic)
IS  - 1662-5153 (Linking)
VI  - 4
DP  - 2010
TI  - The ethics of memory blunting: some initial thoughts.
PG  - 190
LID - 10.3389/fnbeh.2010.00190 [doi]
FAU - Parens, Erik
AU  - Parens E
AD  - Bioethics, The Hastings Center Garrison, NY, USA.
LA  - eng
PT  - Journal Article
DEP - 20101220
PL  - Switzerland
TA  - Front Behav Neurosci
JT  - Frontiers in behavioral neuroscience
JID - 101477952
PMC - PMC3031078
EDAT- 2011/02/02 06:00
MHDA- 2011/02/02 06:01
CRDT- 2011/02/02 06:00
PHST- 2010/12/06 00:00 [received]
PHST- 2010/12/06 00:00 [accepted]
PHST- 2011/02/02 06:00 [entrez]
PHST- 2011/02/02 06:00 [pubmed]
PHST- 2011/02/02 06:01 [medline]
AID - 10.3389/fnbeh.2010.00190 [doi]
PST - epublish
SO  - Front Behav Neurosci. 2010 Dec 20;4:190. doi: 10.3389/fnbeh.2010.00190.
      eCollection 2010.


PMID- 21280473
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20131121
IS  - 0019-4832 (Print)
IS  - 0019-4832 (Linking)
VI  - 62
IP  - 4
DP  - 2010 Jul-Aug
TI  - Requirement of pharmacological treatment for primary prevention of cardiovascular
      disease in asymptomatic office-executives in north-India.
PG  - 324-9
AB  - BACKGROUND: Recently, a concept of multi-drug treatment of all individuals in the
      form of a polypill, irrespective of their risk factor profile, has been proposed 
      with a view to provide an effective means for prevention of cardiovascular
      disease (CVD). While the rationale, benefits and ethicality of such an approach
      continue to remain a matter ofdebate, it is not known what proportion of
      asymptomatic adult population does actually require pharmacological therapy for
      primary prevention of CVD according to the existing guidelines. METHODS: 1927
      consecutive office executives, free of any CVD, undergoing routine health
      check-up at a tertiary care centre in North-India during the year 2005 were
      included in the study. For all subjects, information was collected based on their
      case-records comprising of comprehensive clinical evaluation and the results of
      biochemical investigations. Requirement of treatment with three
      anti-atherosclerotic drugs- aspirin, statin and an anti-hypertensive agent was
      estimated as per the current guidelines. RESULTS: Mean age of the subjects was
      45.2 +/- 10.3 years and 71.6% were males. Diabetes was present in 14.3%,
      hypertension in 46.3% and dyslipidemia in 76.0%. Metabolic syndrome was diagnosed
      in 47.5% subjects. According to the currently accepted guidelines, 47.0% of all
      the individuals were candidates for at least one of the three aforementioned
      drugs--22.9% needed only one drug, 17.8% needed only two drugs and 6.3% needed
      all the three drugs. Requirement of the treatment was much higher in the highest 
      age-tertile (>50 years of age) with 78.0% needing at least one medication, 45.1% 
      needing at least two medications and 12.6% needing all the three drugs (p value <
      0.001). Of the different drugs, aspirin was the most commonly required medicine
      (38.3% of all) and a combination of aspirin and statin was the most commonly
      required two-drug combination. CONCLUSIONS: The present study shows that, in
      spite of high prevalence of CV risk factors, a majority of office-executives who 
      are free of CVD do not require multi-drug therapy for primary prevention of CVD
      as per the current recommendations. Though a greater proportion of the
      individuals > 50 years of age require drug therapy, even among them, a
      triple-drug combination is warranted only in a small proportion of subjects. When
      needed, a combination of statin and aspirin is the most commonly required
      combination.
FAU - Kasliwal, Ravi R
AU  - Kasliwal RR
AD  - Dept. of Cardiology, Medanta-The Medicity, Gurgaon, Haryana, USA.
      rrkasliwal@hotmail.com
FAU - Bansal, Manish
AU  - Bansal M
FAU - Mehrotra, Rahul
AU  - Mehrotra R
FAU - Agrawal, Vinayak
AU  - Agrawal V
FAU - Shrivastava, Sameer
AU  - Shrivastava S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - India
TA  - Indian Heart J
JT  - Indian heart journal
JID - 0374675
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Antihypertensive Agents/*administration & dosage
MH  - Aspirin/*administration & dosage
MH  - Cardiovascular Diseases/epidemiology/*prevention & control
MH  - Chi-Square Distribution
MH  - Comorbidity
MH  - Drug Therapy, Combination
MH  - Female
MH  - Humans
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/*administration & dosage
MH  - India/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - *Primary Prevention
MH  - Retrospective Studies
MH  - Risk Factors
EDAT- 2011/02/02 06:00
MHDA- 2011/02/25 06:00
CRDT- 2011/02/02 06:00
PHST- 2011/02/02 06:00 [entrez]
PHST- 2011/02/02 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
PST - ppublish
SO  - Indian Heart J. 2010 Jul-Aug;62(4):324-9.


PMID- 21280461
OWN - NLM
STAT- MEDLINE
DCOM- 20110217
LR  - 20191210
IS  - 1078-6791 (Print)
IS  - 1078-6791 (Linking)
VI  - 16
IP  - 6
DP  - 2010 Nov-Dec
TI  - Active research fields of acupuncture research: a document co-citation clustering
      analysis of acupuncture literature.
PG  - 38-45
AB  - OBJECTIVE: This study aims to gain an overview of the active fields of
      acupuncture research in the last 5 to 10 years and before that. METHODS: Document
      co-citation clustering analysis method was used in this article. ISI web of
      knowledge-SCI-EXPANDED was used to retrieve the cited references of the documents
      published under the topic "acupuncture." In order to identify the highly
      frequently cited articles, the cited references were ranked by occurrence
      frequency; the frequent threshold value of highly frequently cited articles was
      set at 20, and their cumulative frequency percentage was nearly 10%. In order to 
      identify the correlation between these highly frequently cited articles, a
      references co-occurrence matrix was constructed and then transformed into a
      correlation matrix for co-citation cluster analysis with SPSS 11.5 (SPSS Inc,
      Chicago, Illinois). RESULTS: Between 2006 and 2008, 985 original articles
      involving acupuncture were published, and their nearly 20000 references were
      downloaded. Forty-one frequently cited references ranging from 1976 to 2005 were 
      identified, and a 41x41 co-citation matrix was acquired. The active fields of
      acupuncture research were identified after co-citation cluster analysis.
      CONCLUSION: The active fields in the last 5 to 10 years and previously could be
      identified as follows. (1) Clinical research on acupuncture; (a) studies on the
      safety of acupuncture; (b) the quest for the "placebo" needle and assessment of
      the placebo effect; (c) assessment of the efficacy of acupuncture for chronic
      back pain, osteoarthritis of the knee, and chronic headache. (2) Usage of
      acupuncture: (a) surveys on the trends of acupuncture use; (b) ethical guidelines
      of acupuncture experiments and quality assessment. (3) Experimental research on
      acupuncture mechanism: (a) the neurochemical basis of acupuncture analgesia and
      (b) evaluation of the effects of acupuncture using functional magnetic resonance 
      imaging.
FAU - Li, Hai-Yan
AU  - Li HY
AD  - Institute of Information on Traditional Chinese Medicine, China Academy of
      Chinese Medical Science, Beijing.
FAU - Cui, Lei
AU  - Cui L
FAU - Cui, Meng
AU  - Cui M
FAU - Tong, Yuan-Yuan
AU  - Tong YY
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Altern Ther Health Med
JT  - Alternative therapies in health and medicine
JID - 9502013
SB  - IM
MH  - *Acupuncture Therapy/methods/standards
MH  - *Bibliometrics
MH  - Cluster Analysis
MH  - Humans
MH  - Outcome Assessment, Health Care
MH  - Periodicals as Topic
MH  - Placebo Effect
MH  - *Research
EDAT- 2011/02/02 06:00
MHDA- 2011/02/18 06:00
CRDT- 2011/02/02 06:00
PHST- 2011/02/02 06:00 [entrez]
PHST- 2011/02/02 06:00 [pubmed]
PHST- 2011/02/18 06:00 [medline]
PST - ppublish
SO  - Altern Ther Health Med. 2010 Nov-Dec;16(6):38-45.


PMID- 21275471
OWN - NLM
STAT- MEDLINE
DCOM- 20110407
LR  - 20190518
IS  - 0261-1929 (Print)
IS  - 0261-1929 (Linking)
VI  - 38
IP  - 6
DP  - 2010 Dec
TI  - An assessment of the use of chimpanzees in hepatitis C research past, present and
      future: 2. Alternative replacement methods.
PG  - 471-94
AB  - The use of chimpanzees in hepatitis C virus (HCV) research was examined in the
      report associated with this paper (1: Validity of the chimpanzee model), in which
      it was concluded that claims of past necessity of chimpanzee use were
      exaggerated, and that claims of current and future indispensability were
      unjustifiable. Furthermore, given the serious scientific and ethical issues
      surrounding chimpanzee experimentation, it was proposed that it must now be
      considered redundant--particularly in light of the demonstrable contribution of
      alternative methods to past and current scientific progress, and the future
      promise that these methods hold. This paper builds on this evidence, by examining
      the development of alternative approaches to the investigation of HCV, and by
      reviewing examples of how these methods have contributed, and are continuing to
      contribute substantially, to progress in this field. It augments the argument
      against chimpanzee use by demonstrating the comprehensive nature of these methods
      and the valuable data they deliver. The entire life-cycle of HCV can now be
      investigated in a human (and much more relevant) context, without recourse to
      chimpanzee use. This also includes the testing of new therapies and vaccines.
      Consequently, there is no sound argument against the changes in public policy
      that propose a move away from chimpanzee use in US laboratories.
CI  - 2010 FRAME.
FAU - Bailey, Jarrod
AU  - Bailey J
AD  - New England Anti-Vivisection Society, Boston, MA 02108-5100, USA.
      jarrod.bailey@mac.com
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Altern Lab Anim
JT  - Alternatives to laboratory animals : ATLA
JID - 8110074
SB  - IM
MH  - Animal Experimentation
MH  - *Animal Use Alternatives
MH  - Animal Welfare
MH  - Animals
MH  - *Disease Models, Animal
MH  - Hepacivirus/pathogenicity/*physiology
MH  - Hepatitis C/*physiopathology
MH  - Hepatocytes/*virology
MH  - Humans
MH  - Pan troglodytes
MH  - Species Specificity
MH  - Virus Cultivation
EDAT- 2011/02/01 06:00
MHDA- 2011/04/08 06:00
CRDT- 2011/02/01 06:00
PHST- 2011/02/01 06:00 [entrez]
PHST- 2011/02/01 06:00 [pubmed]
PHST- 2011/04/08 06:00 [medline]
AID - 10.1177/026119291003800602 [doi]
PST - ppublish
SO  - Altern Lab Anim. 2010 Dec;38(6):471-94. doi: 10.1177/026119291003800602.


PMID- 21275353
OWN - NLM
STAT- MEDLINE
DCOM- 20110324
LR  - 20190923
IS  - 0035-8665 (Print)
IS  - 0035-8665 (Linking)
VI  - 156
IP  - 4
DP  - 2010 Dec
TI  - Cold steel and warm hearts: the professional ethics and strategic planning of
      expeditionary warfare.
PG  - 219-20
FAU - Rew, David A
AU  - Rew DA
AD  - Southampton University Hospitals and Defence Medical Services. dr1@soton.ac.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - J R Army Med Corps
JT  - Journal of the Royal Army Medical Corps
JID - 7505627
SB  - IM
MH  - Afghan Campaign 2001-
MH  - *Ethics, Professional
MH  - Health Planning/ethics/organization & administration
MH  - Humans
MH  - Iraq War, 2003-2011
MH  - Military Medicine/*ethics/*organization & administration
MH  - United Kingdom
EDAT- 2011/02/01 06:00
MHDA- 2011/03/25 06:00
CRDT- 2011/02/01 06:00
PHST- 2011/02/01 06:00 [entrez]
PHST- 2011/02/01 06:00 [pubmed]
PHST- 2011/03/25 06:00 [medline]
AID - 10.1136/jramc-156-04-02 [doi]
PST - ppublish
SO  - J R Army Med Corps. 2010 Dec;156(4):219-20. doi: 10.1136/jramc-156-04-02.


PMID- 21274897
OWN - NLM
STAT- MEDLINE
DCOM- 20110425
LR  - 20110128
IS  - 1098-2345 (Electronic)
IS  - 0275-2565 (Linking)
VI  - 73
IP  - 3
DP  - 2011 Mar
TI  - Introduction to the special section: "the effects of bonds between human and
      nonhuman primates on primatological research and practice".
PG  - 211-3
LID - 10.1002/ajp.20906 [doi]
AB  - This commentary introduces this special section on ''the Effects of Bonds Between
      Human and Nonhuman Primates on Primatological Research and Practice.'' The aim is
      to explore the different causes and consequences of bonding experiences between
      observers and observed in different primatological contexts. In the first
      contribution, Vitale asks what are the possible consequences of such bonding in
      behavioral primatology. Examples of beneficial consequences of this kind of
      relationship come fromstudies on cognitive abilities of great apes. Furthermore, 
      an empathic attitude with the experimental animals leads to better care and
      attention toward individual welfare needs. Coleman discusses the particular case 
      of nonhuman primates housed in research laboratories. Care-giving practices
      arediscussed in relation to scientific, ethical and emotional issues. Morimura et
      al. present the case of the first Japanese sanctuary for retiring chimpanzees
      from research where, in order to facilitate the social living of re-located
      chimpanzees, face-to-face interactions between caregivers and chimpanzees
      areessential. Asquith discusses the role of an thropomorphism, and proposes that 
      this attitude can help to better understand the lives of primates, in more
      contextualized scenarios. In relation to this view, sheemphasizes how the term
      ''primate culture'' accords with some definition of the term ''human
      culture.''Fuentes, in his article asks whether national, class and ethnic
      characteristics can influence bonding between human and nonhuman primates, and
      calls for focused quantitative studies. Finally, Rose calls for the application
      of the concept of biosynergy, explained as promoting the formation of healthy and
      sustainable bonding relationships among living creatures. One of the most
      important aspects emerging from these papers is the need to better understand
      whether the issue of bonding in primatological studiescan be generalized to other
      areas of research such as conservation, behavior, captive care, or whether each
      of these disciplines needs to develop their own understanding of the effects of
      bonding in ''producing science.''
CI  - 2010 Wiley-Liss, Inc.
FAU - Vitale, Augusto
AU  - Vitale A
AD  - Section of Behavioural Neuroscience, Department of Cell Biology and Neuroscience,
      Istituto Superiore di Sanita, Rome, Italy. vitale@iss.it
FAU - Pollo, Simone
AU  - Pollo S
LA  - eng
PT  - Introductory Journal Article
DEP - 20101123
PL  - United States
TA  - Am J Primatol
JT  - American journal of primatology
JID - 8108949
SB  - IM
MH  - Animals
MH  - Humans
MH  - *Object Attachment
MH  - Primates/*psychology
MH  - Research Personnel/ethics/*psychology
MH  - Zoology/ethics/*methods/trends
EDAT- 2011/01/29 06:00
MHDA- 2011/04/26 06:00
CRDT- 2011/01/29 06:00
PHST- 2010/10/08 00:00 [received]
PHST- 2010/10/25 00:00 [revised]
PHST- 2010/10/25 00:00 [accepted]
PHST- 2011/01/29 06:00 [entrez]
PHST- 2011/01/29 06:00 [pubmed]
PHST- 2011/04/26 06:00 [medline]
AID - 10.1002/ajp.20906 [doi]
PST - ppublish
SO  - Am J Primatol. 2011 Mar;73(3):211-3. doi: 10.1002/ajp.20906. Epub 2010 Nov 23.


PMID- 21271140
OWN - NLM
STAT- MEDLINE
DCOM- 20111114
LR  - 20190918
IS  - 1806-9282 (Electronic)
IS  - 0104-4230 (Linking)
VI  - 56
IP  - 6
DP  - 2010 Nov-Dec
TI  - [Jehovah's Witnesses attitude towards hemocomponents and hemoderivatives].
PG  - 705-10
LID - S0104-42302010000600022 [pii]
AB  - OBJECTIVE: To study extent of knowledge and acceptance of hemocomponents and
      hemoderivatives, fresh and stored, by Jehovah's Witnesses and also propose
      bioethical tools for any ethical and moral conflicts identified in their
      relationship with physicians and dentists. METHODS: A questionnaire was used to
      interview 150 Jehovah's Witnesses who attend "Saloes do Reino" in the Distrito
      Federal, Brazil. The questionnaire was directed towards information on
      socio-demographic aspects related to the use (or not) of hemocomponents and
      hemoderivatives by those interviewed and also approach of healthcare
      professionals with patients of this belief. RESULTS: 74% believe that the use of 
      blood causes more harm than benefits to health--refusal is essentially based on
      the Bible 96% do not support hemocomponents, but 76% support hemoderivatives in
      specific situations, showing that personal understandings do exist; 80% feel
      morally offended with use of stored blood and only 45% with fresh blood,
      confirming the religious interpretation that fresh products are in general more
      accepted; according to 83% of the interviewees dentists do not ask about
      patients' religion, whereas 71% of physicians do, showing little professional
      concern about this aspect. CONCLUSION: Jehovah's Witnesses are seen by their
      "moral outsiders" (here physicians and dentists) as the religious group that
      simply "does not use blood". Although, several blood treatments are nowadays
      permitted, it does not deprive them from a free conviction to refuse blood
      treatments. Their particular understandings frequently extend the list of blood
      prohibitions and, consequently, the number of moral conflicts, when considering
      that physicians and dentists usually do not ask about a patient's religion.
FAU - Azambuja, Leticia Erig Osorio de
AU  - Azambuja LE
AD  - Universidade de Brasilia, Brasilia, DF. bioetica@unb.br
FAU - Garrafa, Volnei
AU  - Garrafa V
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Testemunhas de jeova ante o uso de hemocomponentes e hemoderivados.
PL  - Brazil
TA  - Rev Assoc Med Bras (1992)
JT  - Revista da Associacao Medica Brasileira (1992)
JID - 9308586
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Blood Preservation/methods/*psychology
MH  - Blood Transfusion/methods/*psychology
MH  - Clinical Competence/*standards
MH  - Cross-Sectional Studies
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - *Jehovah's Witnesses
MH  - Male
MH  - Medical History Taking/standards
MH  - Middle Aged
MH  - Qualitative Research
MH  - Religion and Medicine
MH  - Socioeconomic Factors
MH  - Surveys and Questionnaires
EDAT- 2011/01/29 06:00
MHDA- 2011/11/15 06:00
CRDT- 2011/01/29 06:00
PHST- 2010/08/11 00:00 [received]
PHST- 2010/09/03 00:00 [accepted]
PHST- 2011/01/29 06:00 [entrez]
PHST- 2011/01/29 06:00 [pubmed]
PHST- 2011/11/15 06:00 [medline]
AID - S0104-42302010000600022 [pii]
AID - 10.1590/s0104-42302010000600022 [doi]
PST - ppublish
SO  - Rev Assoc Med Bras (1992). 2010 Nov-Dec;56(6):705-10. doi:
      10.1590/s0104-42302010000600022.


PMID- 21271095
OWN - NLM
STAT- MEDLINE
DCOM- 20111003
LR  - 20220409
IS  - 1809-399X (Electronic)
IS  - 0104-5687 (Linking)
VI  - 22
IP  - 4
DP  - 2010 Oct-Dec
TI  - Postural control of mouth breathing school aged children regarding gender.
PG  - 433-8
LID - S0104-56872010000400012 [pii]
AB  - BACKGROUND: Postural control of mouth breathing school aged children. AIM: To
      compare the posture and body balance of school aged children groups, with and
      without oral breathing considering the variable gender. METHOD: The study was
      developed at a municipal school in the city of Santa Maria (Brazil) and received 
      prior approval of the ethics committee of the University of Santa Maria. The
      study group (with oral breathing) and the control group (without oral breathing) 
      were selected based on an anamnesis, age (between 8 and 12 years), assessment of 
      the stomatognathic system and auditory evaluation. The final sample was composed 
      by 51 children in the study group (20 female and 31 male) and 58 in the control
      group (34 female and 24 male). Both groups were submitted to a dynamic
      posturography (sensory organization test--SOT) and to a postural assessment in
      right and left lateral view. RESULTS: Regarding the female gender, a
      statistically significant difference was observed for the angle that evaluates
      head horizontal alignment; for the SOT III value and for all SOT mean values. As 
      for the male gender, a significant numerical difference was observed for the knee
      angle, for the ankle angle, for the SOT III value, for the SOT IV value and for
      all SOT mean values. CONCLUSION: School aged children with oral breathing present
      postural alterations; females present head positing alterations and males present
      alterations in the position of the inferior limbs. The body balance of school
      aged children with oral breathing, of both genders, demonstrated to be altered
      when compared to children without oral breathing, especially in the presence of
      sensorial conflict.
FAU - Roggia, Bruna
AU  - Roggia B
AD  - Universidade Federal de Santa Maria. brunaroggia@yahoo.com.br
FAU - Correa, Bruna
AU  - Correa B
FAU - Pranke, Gabriel Ivan
AU  - Pranke GI
FAU - Facco, Rudi
AU  - Facco R
FAU - Rossi, Angela Garcia
AU  - Rossi AG
LA  - eng
LA  - por
PT  - Journal Article
PL  - Brazil
TA  - Pro Fono
JT  - Pro-fono : revista de atualizacao cientifica
JID - 100930630
SB  - IM
MH  - Case-Control Studies
MH  - Child
MH  - Female
MH  - Hearing Tests
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Male
MH  - Mouth Breathing/*physiopathology
MH  - Postural Balance/*physiology
MH  - Posture/*physiology
MH  - Sex Factors
MH  - Stomatognathic System/physiology
MH  - Vision, Ocular/physiology
EDAT- 2011/01/29 06:00
MHDA- 2011/10/04 06:00
CRDT- 2011/01/29 06:00
PHST- 2010/04/28 00:00 [received]
PHST- 2010/11/23 00:00 [accepted]
PHST- 2011/01/29 06:00 [entrez]
PHST- 2011/01/29 06:00 [pubmed]
PHST- 2011/10/04 06:00 [medline]
AID - S0104-56872010000400012 [pii]
AID - 10.1590/s0104-56872010000400012 [doi]
PST - ppublish
SO  - Pro Fono. 2010 Oct-Dec;22(4):433-8. doi: 10.1590/s0104-56872010000400012.


PMID- 21268921
OWN - NLM
STAT- MEDLINE
DCOM- 20110215
LR  - 20171116
IS  - 1426-9686 (Print)
IS  - 1426-9686 (Linking)
VI  - 29
IP  - 173
DP  - 2010 Nov
TI  - [Empathy-building of physicians. Part III. Students exposure to literature,
      theatre, film and the arts].
PG  - 331-5
AB  - Literature, theatrical performances, films and the arts could be used to enhance 
      empathy among students of medicine and residents. The use of these media enables 
      them to learn how feelings are expressed. Through study of literature and the
      performing arts students can also gain new insights into their own emotional
      responses to illness and suffering as well as into the moral and ethical issues
      posed by medical practice. The objective of this paper is to describe ways in
      which literature, film, drama, and the arts are used in medical schools to
      enhance empathy in students of medicine. We also want to show the rational
      purpose for the inclusion of these media in medical school training. We searched 
      PubMed, ProQuest, ERIC, MedLine, and Polish Medical Bibliography (Polska
      Bibliografia Lekarska) published from 1990 to the present--for studies that
      address use of literature, drama, film and the arts for teaching empathy to
      medical students. Analysis of papers reporting use of different forms of
      literary, artistic, and performing arts productions within the context of medical
      education indicates that exposure to these types of media, when used properly,
      may trigger attitude change, foster understanding of the illness experience and
      enhance empathy for the patients.
FAU - Ziolkowska-Rudowicz, Elzbieta
AU  - Ziolkowska-Rudowicz E
AD  - Pomorski Uniwersytet Medyczny w Szczecinie, Zaklad Historii Medycyny i Etyki
      Lekarskiej. ssliza@pum.edu.pl
FAU - Kladna, Aleksandra
AU  - Kladna A
LA  - pol
PT  - Journal Article
PT  - Review
TT  - Ksztalcenie empatycznych lekarzy. Czesc III. Kontakt studentow z literatura,
      teatrem, filmem i sztuka.
PL  - Poland
TA  - Pol Merkur Lekarski
JT  - Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
JID - 9705469
SB  - IM
MH  - *Attitude to Health
MH  - *Curriculum
MH  - Drama
MH  - Education, Medical, Undergraduate/*methods
MH  - *Empathy
MH  - Humans
MH  - Medicine in Literature
MH  - *Medicine in the Arts
MH  - Motion Pictures
MH  - *Physician-Patient Relations
MH  - Poland
MH  - Students, Medical/*psychology
MH  - Teaching
EDAT- 2011/01/29 06:00
MHDA- 2011/02/16 06:00
CRDT- 2011/01/29 06:00
PHST- 2011/01/29 06:00 [entrez]
PHST- 2011/01/29 06:00 [pubmed]
PHST- 2011/02/16 06:00 [medline]
PST - ppublish
SO  - Pol Merkur Lekarski. 2010 Nov;29(173):331-5.


PMID- 21268423
OWN - NLM
STAT- MEDLINE
DCOM- 20110318
LR  - 20110126
IS  - 1660-9379 (Print)
IS  - 1660-9379 (Linking)
VI  - 6
IP  - 275
DP  - 2010 Dec 15
TI  - [Assisted suicide in the EMS (Medico-Social Establishment): recommendations for
      ethics consultation of the FEGEMS (Geneva Federation of Medico-Social
      Establishment].
PG  - 2422-4
FAU - Loew, Francois
AU  - Loew F
AD  - Conseil d'ethique de la Fegems, Geneve. conseil.ethique@fegems.ch
FAU - Charvoz, Marie-Rose
AU  - Charvoz MR
FAU - Cramer, Jacqueline
AU  - Cramer J
FAU - Esposito, Aline
AU  - Esposito A
FAU - Fallet, Marcel
AU  - Fallet M
FAU - Lederrey, Jacques
AU  - Lederrey J
FAU - Mechkat, Claire-Line
AU  - Mechkat CL
FAU - Roger, Daniel
AU  - Roger D
FAU - Repond, Anne-Laure
AU  - Repond AL
LA  - fre
PT  - Journal Article
TT  - Assistance au suicide dans les EMS: recommandations du Conseil d'ethique de la
      FEGEMS.
PL  - Switzerland
TA  - Rev Med Suisse
JT  - Revue medicale suisse
JID - 101219148
SB  - IM
MH  - Ethics Consultation/*standards
MH  - *Ethics, Medical
MH  - Humans
MH  - Personal Autonomy
MH  - *Physician's Role
MH  - Practice Guidelines as Topic
MH  - Religion
MH  - Societies, Medical
MH  - Suicide, Assisted/*ethics/legislation & jurisprudence
MH  - Switzerland
MH  - Terminal Care
EDAT- 2011/01/28 06:00
MHDA- 2011/03/19 06:00
CRDT- 2011/01/28 06:00
PHST- 2011/01/28 06:00 [entrez]
PHST- 2011/01/28 06:00 [pubmed]
PHST- 2011/03/19 06:00 [medline]
PST - ppublish
SO  - Rev Med Suisse. 2010 Dec 15;6(275):2422-4.


PMID- 21268418
OWN - NLM
STAT- MEDLINE
DCOM- 20110318
LR  - 20151119
IS  - 1660-9379 (Print)
IS  - 1660-9379 (Linking)
VI  - 6
IP  - 275
DP  - 2010 Dec 15
TI  - [Non invasive ventilation in the ICU for the neuromuscular patient: legal
      issues].
PG  - 2396, 2398-400
AB  - The legal frame in which chronic mechanical ventilation is placed in Switzerland 
      and France is discussed in this article. Safety of the patients and
      responsibility of caregivers are considered. We also discuss the ethical and
      legal aspects of the end-of-life of these patients, particularly when they decide
      that mechanical ventilation must be interrupted because they do not more tolerate
      their poor quality of life, and when they deliberately decide to die.
FAU - Chevrolet, Jean-Claude
AU  - Chevrolet JC
AD  - Service des soins intensifs, HUG, 1211 Geneve 14.
FAU - Janssens, Jean-Paul
AU  - Janssens JP
FAU - Adler, Dan
AU  - Adler D
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Ventilation non invasive et insuffisance respiratoire chronique d'origine
      neuromusculaire: implications pour l'intensiviste. Aspects medico-legaux.
PL  - Switzerland
TA  - Rev Med Suisse
JT  - Revue medicale suisse
JID - 101219148
SB  - IM
MH  - Amyotrophic Lateral Sclerosis/therapy
MH  - Continuous Positive Airway Pressure/ethics
MH  - Critical Care/ethics/*legislation & jurisprudence
MH  - France
MH  - Humans
MH  - Intensive Care Units/legislation & jurisprudence
MH  - Muscular Dystrophy, Duchenne/therapy
MH  - Neuromuscular Diseases/complications/*therapy
MH  - *Positive-Pressure Respiration/ethics
MH  - Prognosis
MH  - Quality of Life
MH  - Respiration, Artificial/ethics
MH  - Respiratory Insufficiency/etiology/*therapy
MH  - Resuscitation/ethics
MH  - Switzerland
MH  - Terminal Care/ethics/*legislation & jurisprudence
MH  - Tracheostomy/ethics/*legislation & jurisprudence
MH  - Withholding Treatment/ethics/*legislation & jurisprudence
EDAT- 2011/01/28 06:00
MHDA- 2011/03/19 06:00
CRDT- 2011/01/28 06:00
PHST- 2011/01/28 06:00 [entrez]
PHST- 2011/01/28 06:00 [pubmed]
PHST- 2011/03/19 06:00 [medline]
PST - ppublish
SO  - Rev Med Suisse. 2010 Dec 15;6(275):2396, 2398-400.


PMID- 21268417
OWN - NLM
STAT- MEDLINE
DCOM- 20110318
LR  - 20110126
IS  - 1660-9379 (Print)
IS  - 1660-9379 (Linking)
VI  - 6
IP  - 275
DP  - 2010 Dec 15
TI  - [Non invasive ventilation in the ICU for the neuromuscular patient: ethical
      issues].
PG  - 2390-5
AB  - Non-invasive mechanical ventilation in patients with chronic neuromuscular
      disorders is an effective tool for treating dyspnea or sleep disturbances often
      observed in such patients. So, NIV has to be considered as a palliative treatment
      and it must systematically be offered to these patients. Mechanical ventilation, 
      non-invasive or invasive (via a trachesotomy) have to be considered
      systematically with patients and families at an earlier stages of these diseases 
      in order to design a strategy in case of acute respiratory failure. In a second
      parent paper of this issue, we discuss the medico-legal implications of
      mechanical ventilation in neuromuscular failure, particularly the end-of-life
      aspects.
FAU - Chevrolet, Jean-Claude
AU  - Chevrolet JC
AD  - Service des soins intensifs, HUG, 1211 Geneve 14.
FAU - Janssens, Jean-Paul
AU  - Janssens JP
FAU - Adler, Dan
AU  - Adler D
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Ventilation non invasive et insuffisance respiratoire chronique d'origine
      neuromusculaire: implications pour l'intensiviste. Aspects ethiques.
PL  - Switzerland
TA  - Rev Med Suisse
JT  - Revue medicale suisse
JID - 101219148
SB  - IM
MH  - Amyotrophic Lateral Sclerosis/therapy
MH  - Humans
MH  - Muscular Dystrophy, Duchenne/therapy
MH  - Neuromuscular Diseases/complications/*therapy
MH  - Palliative Care/*ethics/legislation & jurisprudence
MH  - Positive-Pressure Respiration/*ethics
MH  - Quality of Life
MH  - Respiration, Artificial/ethics
MH  - Respiratory Insufficiency/etiology/*therapy
MH  - Switzerland
MH  - Tracheostomy/*ethics/legislation & jurisprudence
EDAT- 2011/01/28 06:00
MHDA- 2011/03/19 06:00
CRDT- 2011/01/28 06:00
PHST- 2011/01/28 06:00 [entrez]
PHST- 2011/01/28 06:00 [pubmed]
PHST- 2011/03/19 06:00 [medline]
PST - ppublish
SO  - Rev Med Suisse. 2010 Dec 15;6(275):2390-5.


PMID- 21265290
OWN - NLM
STAT- MEDLINE
DCOM- 20110211
LR  - 20220318
IS  - 1526-9248 (Print)
IS  - 1526-9248 (Linking)
VI  - 20
IP  - 4
DP  - 2010 Dec
TI  - Stranger donors: a key link in transplant chains.
PG  - 366-71
AB  - Living donation to strangers is a complex issue that has caused some transplant
      centers to ban the practice altogether. Most prominent of the troublesome issues 
      is the common source of these donors; namely, the Internet. These "stranger
      donors," however, are critical to both paired kidney transplants and chain kidney
      transplants. This article presents the ethical complexities of donors in these
      transplant arrangements and offers 2 case examples from our facility. Rigorous
      donor screening and informed consent processes are crucial, and together they
      help make transplant pairs and chains ethically feasible.
FAU - Veys, Christopher G
AU  - Veys CG
AD  - California Pacific Medical Center, San Francisco, California 94115, USA.
      veys_chris@yahoo.com
FAU - Bramstedt, Katrina A
AU  - Bramstedt KA
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Prog Transplant
JT  - Progress in transplantation (Aliso Viejo, Calif.)
JID - 100909380
MH  - Adult
MH  - Altruism
MH  - Blood Group Incompatibility
MH  - *Directed Tissue Donation/ethics/statistics & numerical data
MH  - *Donor Selection/ethics/organization & administration
MH  - Humans
MH  - Informed Consent/ethics/statistics & numerical data
MH  - *Internet/ethics/organization & administration
MH  - *Kidney Transplantation/ethics/methods/statistics & numerical data
MH  - *Living Donors/ethics/statistics & numerical data
MH  - Male
MH  - *Tissue and Organ Procurement/ethics/organization & administration
MH  - United States
EDAT- 2011/01/27 06:00
MHDA- 2011/02/12 06:00
CRDT- 2011/01/27 06:00
PHST- 2011/01/27 06:00 [entrez]
PHST- 2011/01/27 06:00 [pubmed]
PHST- 2011/02/12 06:00 [medline]
AID - 10.7182/prtr.20.4.v80gh271u37j175x [doi]
PST - ppublish
SO  - Prog Transplant. 2010 Dec;20(4):366-71. doi: 10.7182/prtr.20.4.v80gh271u37j175x.


PMID- 21262118
OWN - NLM
STAT- MEDLINE
DCOM- 20110623
LR  - 20211020
IS  - 2769-819X (Electronic)
IS  - 1532-0820 (Linking)
VI  - 60
IP  - 5
DP  - 2010 Oct
TI  - Endpoints in myelin-deficient (MD) rats.
PG  - 343-7
AB  - Health problems in some animal models remain unexplained, rendering in vivo
      studies ethically challenging, especially when experimental animals are prone to 
      sudden death. Over the last 3 decades, the myelin-deficient (md) rat, a strain
      with severe dysmyelination due to mutant proteolipid protein, has been key to
      important discoveries in mechanisms of myelination and glial cell biology. The
      usefulness of this mutant rat, however, has been limited by sudden death during
      the fourth week of life. Timely euthanasia has been difficult because the cause
      of these mortalities remains unexplained and the endpoint not determined. In this
      clinicopathologic study, we determined that sudden onset of hindlimb paralysis
      inevitably leads to paralysis of the urinary bladder and then breathing
      difficulties because of severe injury to the spinal cord in the midthoracic
      region with concurrent narrowing of the vertebral canal due to fracture of a
      vertebral body. Sudden onset of hindlimb paralysis likely is related to seizures 
      and severe muscle spasms that begin to occur at the end of the third week of
      life. Once seizure activity begins, we recommend frequent monitoring of md rats
      for hindlimb paralysis and distention of the urinary bladder as indication of
      endpoints mandating prompt euthanasia.
FAU - Kwiecien, Jacek M
AU  - Kwiecien JM
AD  - Department of Pathology and Molecular Medicine, McMaster University, Hamilton,
      Ontario, Canada. Kwiecien@mcmaster.ca
FAU - Delaney, Kathleen H
AU  - Delaney KH
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Comp Med
JT  - Comparative medicine
JID - 100900466
RN  - 0 (Myelin Proteolipid Protein)
SB  - IM
MH  - *Animal Welfare
MH  - Animals
MH  - Cause of Death
MH  - Death, Sudden/pathology/*veterinary
MH  - *Disease Models, Animal
MH  - *Endpoint Determination
MH  - Euthanasia, Animal
MH  - Female
MH  - Heterozygote
MH  - Male
MH  - Myelin Proteolipid Protein/*genetics
MH  - Paralysis/pathology/veterinary
MH  - Rats/*genetics
MH  - Rats, Wistar
MH  - Seizures/pathology/veterinary
MH  - Time Factors
PMC - PMC2958201
EDAT- 2011/01/26 06:00
MHDA- 2011/06/24 06:00
CRDT- 2011/01/26 06:00
PHST- 2011/01/26 06:00 [entrez]
PHST- 2011/01/26 06:00 [pubmed]
PHST- 2011/06/24 06:00 [medline]
PST - ppublish
SO  - Comp Med. 2010 Oct;60(5):343-7.


PMID- 21261213
OWN - NLM
STAT- MEDLINE
DCOM- 20110406
LR  - 20211020
IS  - 1121-189X (Print)
IS  - 1121-189X (Linking)
VI  - 19
IP  - 3
DP  - 2010 Jul-Sep
TI  - The many lives of an (associate) editor.
PG  - 200-3
AB  - The role of editor of a journal attracts the vision of a scholar isolated in an
      ivory tower selecting "la creme" of the submitted papers, with no other
      preoccupations that the scientific rigour. This, is of course, only one of the
      many roles - or, as this editorial calls them, lives--of an editor. The essential
      skills are many and more complex, and an editor will encounter many problems that
      are related to such diverse issues as anticipating scientific trends,
      investigating misbehaviours, settling ethical disputes, and interfacing with the 
      lay press. It is exciting and rewarding, and never predictable.
FAU - Pariante, Carmine M
AU  - Pariante CM
LA  - eng
GR  - G108/603/MRC_/Medical Research Council/United Kingdom
GR  - MR/J002739/1/MRC_/Medical Research Council/United Kingdom
PT  - Editorial
PL  - Italy
TA  - Epidemiol Psichiatr Soc
JT  - Epidemiologia e psichiatria sociale
JID - 9501447
SB  - IM
MH  - *Editorial Policies
MH  - Publishing/*standards
EDAT- 2011/01/26 06:00
MHDA- 2011/04/07 06:00
CRDT- 2011/01/26 06:00
PHST- 2011/01/26 06:00 [entrez]
PHST- 2011/01/26 06:00 [pubmed]
PHST- 2011/04/07 06:00 [medline]
PST - ppublish
SO  - Epidemiol Psichiatr Soc. 2010 Jul-Sep;19(3):200-3.


PMID- 21261211
OWN - NLM
STAT- MEDLINE
DCOM- 20110406
LR  - 20110125
IS  - 1121-189X (Print)
IS  - 1121-189X (Linking)
VI  - 19
IP  - 3
DP  - 2010 Jul-Sep
TI  - Authors are not criminals and editors should not be policemen.
PG  - 193-5
AB  - Authors are a necessary and most appreciated basis for the publishing of any
      scientific journal. They should be welcomed for their creativity, originality and
      productivity, not stigmatized in general as cheaters and criminals because a very
      few were tempted beyond their control to cut the slices a bit too thin, overdo
      the utilization of leftover data, listed too many authors to a paper, forgot to
      report a harmless study to an ethical committee, or in very few cases commit
      severe actions of fraud. The managerial way of thinking, meeting every author
      with systems of control and limitations is like poison to creative minds. Instead
      of appointing editors as policemen, we may preferably meet the vast majority of
      classical scholarly working scientists with trust, confidence and support,
      facilitating the process of disseminating the results from their creative
      minds--and of course consequently show the deliberately cheating researchers the 
      door when they act unfaithfully to the scientific society.
FAU - Jorgensen, Povl Munk
AU  - Jorgensen PM
LA  - eng
PT  - Editorial
PL  - Italy
TA  - Epidemiol Psichiatr Soc
JT  - Epidemiologia e psichiatria sociale
JID - 9501447
SB  - IM
MH  - *Authorship
MH  - *Editorial Policies
MH  - Publishing/*standards
MH  - *Scientific Misconduct
EDAT- 2011/01/26 06:00
MHDA- 2011/04/07 06:00
CRDT- 2011/01/26 06:00
PHST- 2011/01/26 06:00 [entrez]
PHST- 2011/01/26 06:00 [pubmed]
PHST- 2011/04/07 06:00 [medline]
PST - ppublish
SO  - Epidemiol Psichiatr Soc. 2010 Jul-Sep;19(3):193-5.


PMID- 21260942
OWN - NLM
STAT- MEDLINE
DCOM- 20110525
LR  - 20220409
IS  - 1460-9592 (Electronic)
IS  - 1155-5645 (Linking)
VI  - 20
IP  - 12
DP  - 2010 Dec
TI  - Entropy monitoring decreases isoflurane concentration and recovery time in
      pediatric day care surgery--a randomized controlled trial.
PG  - 1105-10
AB  - AIM: To assess if titrating anesthesia with entropy would result in faster
      awakening in children undergoing day care surgery. BACKGROUND: Entropy, an
      EEG-based anesthesia depth monitor, has been used in children; however, only one 
      other study has evaluated the effectiveness of entropy monitoring in decreasing
      awakening time and for titrating anesthetic agents in children undergoing short
      procedures under anesthesia. METHODS: In a randomized prospective single-blind
      parallel group trial, 50 ASA grade I-II children, aged 2-12 years, scheduled for 
      lower abdominal or urological surgeries were studied after ethics committee
      approval and parental consent. The children were randomized to the entropy or
      control group. Following laryngeal mask airway insertion and caudal analgesia,
      anesthesia was maintained with nitrous oxide, oxygen, isoflurane. In the control 
      group, anesthesia was titrated according to the hemodynamic parameters and the
      simultaneously monitored entropy values obscured from the anesthesiologist. In
      the entropy group, the entropy values (between 45 and 65) were used to titrate
      the anesthesia. RESULTS: Time to awakening from anesthesia was 7 (3-18) min in
      the entropy group when compared to 10 (5-21) min in the control group. (P < 0.05)
      The difference in the mean time to awakening was 2.72 min 95% CI (0.34, 5.1). The
      end tidal isoflurane concentrations were lower in the entropy group when compared
      to the control group 15 s following airway insertion (0.78 +/- 0.14 vs 1.24 +/-
      0.19), 15 s post caudal and skin incision (0.68 +/- 0.40 vs 0.84 +/- 0.05, 0.68
      +/- 0.03 vs 0.77 +/- 0.32, respectively) as well as 5 min after skin incision
      0.67 +/- 0.04 vs 0.79 +/- 0.02), (P </= 0.05). CONCLUSION: In pediatric day care 
      surgery, entropy monitoring resulted in statistically though not clinically
      significant faster awakening and significantly lower end - tidal isoflurane
      concentrations.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Talawar, Praveen
AU  - Talawar P
AD  - Department of Anaesthesiology & Intensive Care, All India Institute of Medical
      Sciences, Ansari Nagar, New Delhi, India.
FAU - Chhabra, Anjolie
AU  - Chhabra A
FAU - Trikha, Anjan
AU  - Trikha A
FAU - Arora, Mahesh Kumar
AU  - Arora MK
FAU - Chandralekha
AU  - Chandralekha
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - France
TA  - Paediatr Anaesth
JT  - Paediatric anaesthesia
JID - 9206575
RN  - 0 (Anesthetics, Inhalation)
RN  - CYS9AKD70P (Isoflurane)
SB  - IM
MH  - *Ambulatory Surgical Procedures
MH  - *Anesthesia Recovery Period
MH  - Anesthetics, Inhalation/*administration & dosage
MH  - Child
MH  - Child, Preschool
MH  - Electroencephalography
MH  - *Entropy
MH  - Female
MH  - Humans
MH  - Isoflurane/*administration & dosage
MH  - Male
MH  - Monitoring, Intraoperative/*methods
MH  - Prospective Studies
MH  - Single-Blind Method
EDAT- 2011/01/25 06:00
MHDA- 2011/05/26 06:00
CRDT- 2011/01/25 06:00
PHST- 2011/01/25 06:00 [entrez]
PHST- 2011/01/25 06:00 [pubmed]
PHST- 2011/05/26 06:00 [medline]
AID - 10.1111/j.1460-9592.2010.03441.x [doi]
PST - ppublish
SO  - Paediatr Anaesth. 2010 Dec;20(12):1105-10. doi: 10.1111/j.1460-9592.2010.03441.x.


PMID- 21258287
OWN - NLM
STAT- MEDLINE
DCOM- 20160610
LR  - 20161021
IS  - 0351-3254 (Print)
IS  - 0351-3254 (Linking)
VI  - 31
IP  - 2
DP  - 2010
TI  - Some characteristics of patients with schizophrenia who attempted suicide.
PG  - 183-93
AB  - OBJECTIVES: The aim of this study was to determinate some characteristics of
      schizophrenia patients who attempted suicide at the Skopje Psychiatric Hospital, 
      Skopje, with respect to clinical, ethical and legal context. METHODS: The study
      included 80 patients with schizophrenia, 17.5% (n=14) of whom attempted suicide. 
      The psychiatric diagnosis of schizophrenia was based on ICD-10 criteria.
      Sociodemographic and clinical data are presented descriptively as percentages.
      RESULTS: Based on the characteristics of patients with schizophrenia who
      attempted suicide, we obtained a typical profile as follows: middle-aged persons 
      (average age 44.8), single (71.4% were not married and 35.7% lived alone),
      (87.5%) unemployed, repeatedly hospitalized and had a history of suicide attempts
      (50%), attempting suicide using a violent method (poisoning 64.3%, drowning
      21.4%, slashing their wrists 14.3%, jumped from a height 7.1% etc.) after more
      than three weeks of hospital treatment, and out of hospital. The success of
      psychiatric treatment is the perception of the legal and medical aspects of
      suicide as well as their efficient balancing.
FAU - Isjanovski, Viktor
AU  - Isjanovski V
AD  - Skopje Psychiatric Hospital, Skopje, R. Macedonia.
FAU - Vukovic, Vilma
AU  - Vukovic V
FAU - Hadjihamza, Kadri
AU  - Hadjihamza K
FAU - Pejoska-Gerazova, Vesna
AU  - Pejoska-Gerazova V
FAU - Raleva, Marija
AU  - Raleva M
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Prilozi
JT  - Prilozi
JID - 101189513
SB  - IM
MH  - Adult
MH  - Female
MH  - Hospitalization/statistics & numerical data
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Schizophrenia/*epidemiology
MH  - Suicide, Attempted/*psychology/statistics & numerical data
EDAT- 2011/01/25 06:00
MHDA- 2016/06/11 06:00
CRDT- 2011/01/25 06:00
PHST- 2011/01/25 06:00 [entrez]
PHST- 2011/01/25 06:00 [pubmed]
PHST- 2016/06/11 06:00 [medline]
PST - ppublish
SO  - Prilozi. 2010;31(2):183-93.


PMID- 21256457
OWN - NLM
STAT- MEDLINE
DCOM- 20110309
LR  - 20181201
IS  - 1878-1810 (Electronic)
IS  - 1878-1810 (Linking)
VI  - 157
IP  - 2
DP  - 2011 Feb
TI  - Bone marrow stromal cells as replacement cells for Parkinson's disease:
      generation of an anatomical but not functional neuronal phenotype.
PG  - 56-63
LID - 10.1016/j.trsl.2010.11.001 [doi]
AB  - The focus of cell replacement therapies (CRTs) for Parkinson's disease has been
      on delivering dopamine-producing cells to the striatum. Fetal grafts have proven 
      the feasibility of this approach, but an appropriate source of replacement cells 
      has restricted the clinical translation. Bone marrow stromal cells (BMSCs) have
      been heralded as an ideal source of dopaminergic (DAergic) replacement cells, as 
      they are viewed as ethically acceptable, easily procured, and readily expanded.
      It is known that they confer functional benefits, particularly in stroke models, 
      through the release of neurotrophic factors, but their transdifferentiation into 
      neurons is still under contention. We sought to evaluate the neuronal phenotype
      and functional capacity of adult rat BMSCs after exposure to a novel multistep in
      vitro differentiation protocol compared with cells exposed to other reported
      neuronal differentiation conditions. We employed a systematic, comprehensive
      method of assessment to determine the neuronal differentiation capacity of BMSCs.
      Our fluorescence-activated cell sorting, immunofluorescent and semiquantitative
      polymerase chain reaction results confirmed that undifferentiated BMSCs isolated 
      based on their adherence to plastic are of mesenchymal origin and express a range
      of lineage markers. After exposure to preinduction and neuronal induction steps, 
      BMSCs down-regulate markers of other lineages but fail, as assessed by patch
      clamp, to differentiate into functional neurons. Thus, for BMSCs to be considered
      a source of DAergic neuronal replacement cells, their ability to
      transdifferentiate terminally along a neuronal lineage first must be clarified
      before attempting to direct more complex specification process required for them 
      to be used in Parkinson's-disease-focused CRTs.
CI  - Crown Copyright (c) 2011. Published by Mosby, Inc. All rights reserved.
FAU - Thomas, Meghan G
AU  - Thomas MG
AD  - Parkinson's Centre, Edith Cowan University, Perth, Western Australia; School of
      Exercise Biomedical and Health Science, Edith Cowan University, Perth, Western
      Australia, Australia. m.thomas@ecu.edu.au
FAU - Stone, Leah
AU  - Stone L
FAU - Evill, Lauren
AU  - Evill L
FAU - Ong, Syerna
AU  - Ong S
FAU - Ziman, Mel
AU  - Ziman M
FAU - Hool, Livia
AU  - Hool L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101205
PL  - United States
TA  - Transl Res
JT  - Translational research : the journal of laboratory and clinical medicine
JID - 101280339
SB  - IM
CIN - Transl Res. 2011 Feb;157(2):53-5. PMID: 21256456
MH  - Animals
MH  - *Bone Marrow Cells/cytology/metabolism
MH  - *Bone Marrow Transplantation
MH  - Cell Differentiation
MH  - Cell Lineage
MH  - Female
MH  - Flow Cytometry
MH  - Fluorescent Antibody Technique
MH  - Mesenchymal Stem Cells/cytology
MH  - Neurons/cytology/metabolism/*physiology
MH  - Parkinson Disease/*therapy
MH  - Phenotype
MH  - Rats
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Stromal Cells/cytology/metabolism/*transplantation
EDAT- 2011/01/25 06:00
MHDA- 2011/03/10 06:00
CRDT- 2011/01/25 06:00
PHST- 2010/04/12 00:00 [received]
PHST- 2010/11/04 00:00 [revised]
PHST- 2010/11/04 00:00 [accepted]
PHST- 2011/01/25 06:00 [entrez]
PHST- 2011/01/25 06:00 [pubmed]
PHST- 2011/03/10 06:00 [medline]
AID - S1931-5244(10)00289-6 [pii]
AID - 10.1016/j.trsl.2010.11.001 [doi]
PST - ppublish
SO  - Transl Res. 2011 Feb;157(2):56-63. doi: 10.1016/j.trsl.2010.11.001. Epub 2010 Dec
      5.


PMID- 21255750
OWN - NLM
STAT- MEDLINE
DCOM- 20110428
LR  - 20220311
IS  - 1876-4754 (Electronic)
IS  - 1876-4754 (Linking)
VI  - 4
IP  - 1
DP  - 2011 Jan
TI  - Electrodes in the brain--ethical criteria for research and treatment with deep
      brain stimulation for neuropsychiatric disorders.
PG  - 7-16
LID - 10.1016/j.brs.2010.03.002 [doi]
AB  - BACKGROUND: Deep brain stimulation (DBS) has been used for neuropsychiatric
      disorders in clinical and research settings for almost 50 years now. Recent
      evidence demonstrates some efficacy in treating obsessive-compulsive disorder and
      major depression in patients refractory to other treatment modalities beyond
      single case reports. This has led to a considerable surge of clinical and
      commercial interest in DBS for psychiatric indications. Because of the high
      vulnerability of psychiatric patients, the lack of extensive short- and long-term
      data about effectiveness and the rapid spread of questionable indications this
      new field in psychiatry requires ethical criteria that can be applied to both
      research and clinical decision-making. OBJECTIVE AND METHODS: We here present an 
      evidence-based systematic ethical analysis of psychiatric DBS using the criteria 
      of beneficence, nonmaleficence, and autonomy. RESULTS AND CONCLUSIONS: The
      proposed criteria are helpful in analyzing empirical evidence, informing research
      investigations and guiding clinical decision-making. This will prepare the ground
      for ethically justified, empirically comprehensive DBS in this highly vulnerable 
      population and allow stringent future societal discussions about its
      legitimation.
CI  - Copyright A(c) 2011 Elsevier Inc. All rights reserved.
FAU - Synofzik, Matthis
AU  - Synofzik M
AD  - Department for Neurodegenerative Diseases, Hertie-Institute for Clinical Brain
      Research, University of Tubingen, Germany.
FAU - Schlaepfer, Thomas E
AU  - Schlaepfer TE
LA  - eng
PT  - Journal Article
DEP - 20100321
PL  - United States
TA  - Brain Stimul
JT  - Brain stimulation
JID - 101465726
SB  - IM
MH  - Decision Making
MH  - Deep Brain Stimulation/adverse effects/*ethics
MH  - Guidelines as Topic
MH  - Humans
MH  - Mental Disorders/*therapy
MH  - Patient Preference
EDAT- 2011/01/25 06:00
MHDA- 2011/04/29 06:00
CRDT- 2011/01/25 06:00
PHST- 2009/07/27 00:00 [received]
PHST- 2010/01/12 00:00 [revised]
PHST- 2010/01/14 00:00 [accepted]
PHST- 2011/01/25 06:00 [entrez]
PHST- 2011/01/25 06:00 [pubmed]
PHST- 2011/04/29 06:00 [medline]
AID - S1935-861X(10)00020-3 [pii]
AID - 10.1016/j.brs.2010.03.002 [doi]
PST - ppublish
SO  - Brain Stimul. 2011 Jan;4(1):7-16. doi: 10.1016/j.brs.2010.03.002. Epub 2010 Mar
      21.


PMID- 21255521
OWN - NLM
STAT- MEDLINE
DCOM- 20110315
LR  - 20150514
IS  - 0002-5151 (Print)
IS  - 0002-5151 (Linking)
VI  - 57
IP  - 4
DP  - 2010 Jul-Aug
TI  - [Ethics in medical journal reports].
PG  - 105-6
FAU - Becerril Angeles, Martin
AU  - Becerril Angeles M
LA  - spa
PT  - Editorial
TT  - La etica en las publicaciones de revistas medicas.
PL  - Mexico
TA  - Rev Alerg Mex
JT  - Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)
JID - 9438824
SB  - IM
MH  - Journalism/*ethics
MH  - Mexico
MH  - Periodicals as Topic/ethics/*standards
MH  - Scientific Misconduct
EDAT- 2011/01/25 06:00
MHDA- 2011/03/16 06:00
CRDT- 2011/01/25 06:00
PHST- 2011/01/25 06:00 [entrez]
PHST- 2011/01/25 06:00 [pubmed]
PHST- 2011/03/16 06:00 [medline]
PST - ppublish
SO  - Rev Alerg Mex. 2010 Jul-Aug;57(4):105-6.


PMID- 21252593
OWN - NLM
STAT- MEDLINE
DCOM- 20110609
LR  - 20181201
IS  - 1648-9144 (Electronic)
IS  - 1010-660X (Linking)
VI  - 46
IP  - 9
DP  - 2010
TI  - Ethical dilemmas concerning decision-making within health care leadership: a
      systematic literature review.
PG  - 595-603
AB  - UNLABELLED: The objective was to describe the research methods and research
      focuses on ethical dilemmas concerning decision-making within health care
      leadership. MATERIAL AND METHODS: The search was conducted on Medline and PubMed 
      databases (1998-2008). The systematic review included 21 selected articles.
      RESULTS: The ethical dilemmas concerning decision-making within health care
      leadership are related to three levels: institutional (particular organization), 
      political and local interface (local governmental structure), and national
      (professional expertise and system). The terms that are used as adequate to the
      term of "ethical dilemma" are the following: "continuous balancing," "result of
      resource allocation," "gap between professional obligations and possibilities,"
      "ethically controversial situation," "concern about interactions," "ethical
      difficulty," "outcome of medical choices," "concern about society access to
      health care resources," "ethically difficult/challenging situation," "(the
      consequence of) ethical concern/ethical issue." In qualitative studies, a
      semi-structured interview and qualitative content analysis are the most commonly 
      applied methods; in quantitative studies, questionnaire surveys are employed. In 
      the research literature, there is a lack of specification according to
      professional qualification of health care professionals concerning ethical
      dilemmas by decision-making within health care management/administration.
      CONCLUSIONS: The research on ethical dilemmas in health care leadership,
      management, and administration should integrate data about levels at which
      ethical dilemmas occur and investigate ethical dilemmas as complex phenomena
      because those are attached to decision-making and specific nuances of health care
      management/administration. In this article, the presented scientific problem
      requires extensive scientific discussions and research on ethical dilemmas
      concerning decision-making within health care leadership at various levels.
FAU - Zydziunaite, Vilma
AU  - Zydziunaite V
AD  - Department of Nursing Science, Faculty of Medicine, University of Tampere,
      Tampere, Finland. vilma.vilma@ymail.com
FAU - Suominen, Tarja
AU  - Suominen T
FAU - Astedt-Kurki, Paivi
AU  - Astedt-Kurki P
FAU - Lepaite, Daiva
AU  - Lepaite D
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
PL  - Switzerland
TA  - Medicina (Kaunas)
JT  - Medicina (Kaunas, Lithuania)
JID - 9425208
SB  - IM
MH  - *Decision Making
MH  - *Delivery of Health Care
MH  - *Ethics
MH  - Humans
MH  - Interviews as Topic
MH  - *Leadership
MH  - Research
EDAT- 2011/01/22 06:00
MHDA- 2011/06/10 06:00
CRDT- 2011/01/22 06:00
PHST- 2011/01/22 06:00 [entrez]
PHST- 2011/01/22 06:00 [pubmed]
PHST- 2011/06/10 06:00 [medline]
AID - 1009-03 [pii]
PST - ppublish
SO  - Medicina (Kaunas). 2010;46(9):595-603.


PMID- 21252452
OWN - NLM
STAT- MEDLINE
DCOM- 20110512
LR  - 20191112
IS  - 1972-2680 (Electronic)
IS  - 1972-2680 (Linking)
VI  - 4
IP  - 11
DP  - 2010 Nov 24
TI  - Evaluation of a recombinant DNA hepatitis B vaccine in a vaccinated Nigerian
      population.
PG  - 740-4
AB  - INTRODUCTION: Recombinant hepatitis B vaccine was introduced in 1986 and has
      gradually replaced the plasma-derived hepatitis B vaccine. No published data are 
      available on the immunogenicity of hepatitis B vaccines in Nigerians. The current
      study aimed to evaluate protective sero-conversion rates after vaccination with
      Shanvac-B rDNA hepatitis B vaccine in Nigerian subjects between January and
      September 2009. METHODOLOGY: After having obtained informed consent and ethical
      clearance, 2 mL of blood were aseptically collected from each participant aged
      </=50 years, one month after the first, second and third doses of the vaccine.
      Sera were separated into cryovials and frozen at -21oC until analysed for the
      detection of the protective antibody titre induction. Protective antibody titre
      was defined as a titre of >/=10 mIU/mL. RESULTS: Of the 376 participants, 192
      (51.1%) were males and 184 (48.9%) were females. A total of 144 subjects
      participated in the first-dose group, nine (6.3%) of whom developed protective
      antibody titre (8.3% of males and 4.2% of females). Of the 121 participants in
      the second-dose group, 108 (89.3%) developed protective antibody titre (98.3% of 
      males and 80.3% of females), while of the 111 participants in the third-dose
      group, 100% protectively sero-converted. Males were more likely to develop
      protective antibody titre than females after the second dose (P < 0.05).
      CONCLUSION: This data provides additional evidence for the efficacy of Shanvac-B 
      rDNA hepatitis B vaccine and the need to adhere to the recommended three-dose
      schedule to achieve full and lasting sero-protection among Nigerians.
FAU - Adoga, Moses P
AU  - Adoga MP
AD  - Faculty of Natural and Applied Sciences, Nasarawa State University, Keffi,
      Nigeria. adogamoses@yahoo.com
FAU - Pennap, Grace
AU  - Pennap G
FAU - Akande, Becky O
AU  - Akande BO
FAU - Mairiga, Jamey P
AU  - Mairiga JP
FAU - Pechulano, Simon
AU  - Pechulano S
FAU - Agwale, Simon M
AU  - Agwale SM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101124
PL  - Italy
TA  - J Infect Dev Ctries
JT  - Journal of infection in developing countries
JID - 101305410
RN  - 0 (Hepatitis B Antibodies)
RN  - 0 (Hepatitis B Vaccines)
RN  - 0 (Shanvac B)
RN  - 0 (Vaccines, Synthetic)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Hepatitis B/immunology/*prevention & control
MH  - Hepatitis B Antibodies/*blood
MH  - Hepatitis B Vaccines/*administration & dosage/immunology
MH  - Humans
MH  - Immunization Schedule
MH  - Infant
MH  - Male
MH  - Middle Aged
MH  - Nigeria
MH  - Treatment Outcome
MH  - Vaccination
MH  - Vaccines, Synthetic/administration & dosage/immunology
MH  - Young Adult
EDAT- 2011/01/22 06:00
MHDA- 2011/05/13 06:00
CRDT- 2011/01/22 06:00
PHST- 2010/01/09 00:00 [received]
PHST- 2010/07/04 00:00 [accepted]
PHST- 2010/06/24 00:00 [revised]
PHST- 2011/01/22 06:00 [entrez]
PHST- 2011/01/22 06:00 [pubmed]
PHST- 2011/05/13 06:00 [medline]
AID - 10.3855/jidc.823 [doi]
PST - epublish
SO  - J Infect Dev Ctries. 2010 Nov 24;4(11):740-4. doi: 10.3855/jidc.823.


PMID- 21251456
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20211020
IS  - 2385-2070 (Electronic)
IS  - 1723-2007 (Linking)
VI  - 9
IP  - 3
DP  - 2011 Jul
TI  - Informed consent for cord blood donation. A theoretical and empirical study.
PG  - 292-300
LID - 10.2450/2010.0083-10 [doi]
AB  - BACKGROUND AND OBJECTIVES: Umbilical cord blood (CB) banking and therapeutic use 
      raise several ethical issues: medical indications, legal framework, public versus
      private biobanks, autologous versus allogeneic use, ownership, commercialisation,
      quality assurance and many others. Surrogate informed consent is one of the most 
      notable controversial ethical issues. The aim of this study was to analyse and
      compare informed consent forms for CB collection, storage and use in the 18
      accredited biobanks of the Italian Network. MATERIAL AND METHODS: The first part 
      of the article gives a brief overview of the scientific framework, the comparison
      of allogeneic and autologous use and Italian regulations. In the second part the 
      contents of the consent forms from the 18 Italian biobanks are compared with the 
      "NetCord-FACT International Standards for Cord Blood Collection, Banking, and
      Release for Administration". RESULTS: Most of the Italian consent forms differ
      significantly from the NetCord-FACT Standards, with regards both to formal and
      substantial aspects. CONCLUSION: Italian forms for CB collection, storage and use
      need standardisation to meet international criteria.
FAU - Petrini, Carlo
AU  - Petrini C
AD  - Bioethics Unit, Office of the President, Italian National Institute of Health,
      Rome.
FAU - Farisco, Michele
AU  - Farisco M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
DEP - 20101227
PL  - Italy
TA  - Blood Transfus
JT  - Blood transfusion = Trasfusione del sangue
JID - 101237479
SB  - IM
MH  - *Bioethical Issues
MH  - Blood Banks/*ethics/legislation & jurisprudence/methods/organization &
      administration
MH  - Blood Donors/*ethics/legislation & jurisprudence
MH  - Blood Preservation/*ethics/methods
MH  - Consent Forms/*ethics/standards
MH  - *Fetal Blood
MH  - Humans
MH  - Italy
PMC - PMC3136597
EDAT- 2011/01/22 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/01/22 06:00
PHST- 2010/09/17 00:00 [received]
PHST- 2010/10/19 00:00 [accepted]
PHST- 2011/01/22 06:00 [entrez]
PHST- 2011/01/22 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - 2010.0083-10 [pii]
AID - 10.2450/2010.0083-10 [doi]
PST - ppublish
SO  - Blood Transfus. 2011 Jul;9(3):292-300. doi: 10.2450/2010.0083-10. Epub 2010 Dec
      27.


PMID- 21249291
OWN - NLM
STAT- MEDLINE
DCOM- 20111123
LR  - 20181201
IS  - 0034-9887 (Print)
IS  - 0034-9887 (Linking)
VI  - 138
IP  - 9
DP  - 2010 Sep
TI  - [Transparency in biomedical research: about the risks associated with the use of 
      Avandia].
PG  - 1197-200
LID - /S0034-98872010000900017 [doi]
AB  - The question of how and when to communicate potential risks associated with new
      drugs has remained an important focus of tension between the pharmaceutical
      industry and regulatory entities, such as the American Food and Drug
      Administration. Recently there has been widespread concern related to the
      cardiovascular risks associated with the use of Avandia, a rosiglitazone produced
      by Glaxo Smith Kline. In fact, several metaanalyses involving rosiglitazone
      provided a relatively consistent message that rosiglitazone increases the risk of
      myocardial ischemic events. In the present article, we review the controversy
      regarding the way the pharmaceutical company handled this issue, and we describe 
      examples of inappropriate conduct regarding an industry-sponsored clinical trial 
      with this drug. We raise several important ethical questions related to the way
      researchers handle conflicts of interest when they are employees of the
      pharmaceutical industry. Finally, we discuss the requirements to conduct
      biomedical research funded by the pharmaceutical industry in Chile.
FAU - Salas, Sofia P
AU  - Salas SP
AD  - Escuela de Medicina, Universidad Diego Portales, Chile. sofia.salad@udp.cl
FAU - Russo, Moises
AU  - Russo M
LA  - spa
PT  - Journal Article
TT  - Transparencia en la investigacion biomedica: A proposito de los riesgos asociados
      al uso de Avandia.
DEP - 20101109
PL  - Chile
TA  - Rev Med Chil
JT  - Revista medica de Chile
JID - 0404312
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Thiazolidinediones)
RN  - 05V02F2KDG (Rosiglitazone)
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Cardiovascular Diseases/*chemically induced
MH  - Chile
MH  - Conflict of Interest
MH  - Drug Industry/*ethics
MH  - Humans
MH  - Hypoglycemic Agents/*adverse effects
MH  - Research Personnel/ethics
MH  - Risk Factors
MH  - Rosiglitazone
MH  - Thiazolidinediones/*adverse effects
EDAT- 2011/01/21 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/01/21 06:00
PHST- 2011/01/21 06:00 [entrez]
PHST- 2011/01/21 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0034-98872010000900017 [pii]
AID - /S0034-98872010000900017 [doi]
PST - ppublish
SO  - Rev Med Chil. 2010 Sep;138(9):1197-200. doi: /S0034-98872010000900017. Epub 2010 
      Nov 9.


PMID- 21245585
OWN - NLM
STAT- MEDLINE
DCOM- 20110412
LR  - 20161125
IS  - 0019-557X (Print)
IS  - 0019-557X (Linking)
VI  - 54
IP  - 3
DP  - 2010 Jul-Sep
TI  - Is NDM-1 actually being imported to UK from India?
PG  - 151-4
LID - 10.4103/0019-557X.75738 [doi]
AB  - A recent article in Lancet Infectious Diseases suggested that Enterobacteriaceae 
      containing New Delhi metallo-betalactamase (NDM-1) gene were being imported into 
      UK from India. Since the study findings had widespread public health
      implications, it was necessary to scrutinise the adequacy of the evidence. The
      article was critically appraised on epidemiological, biological, and molecular
      evidence, the ethical principle of research, potential conflict of interest, and 
      the justifiability of the recommendations. The study design was inappropriate to 
      establish a causal chain between hospitalization in India and importation of
      NDM-1 in UK. Out of the total 29 NDM-1 positive UK patients, the NDM-1 gene was
      present in equal proportion among those who were hospitalized in India (44.3%)
      and those who were not (51.7%). Statistically significant strain relatedness
      between Indian and UK isolates could not be proved through dendrogram. There was 
      a potential conflict of interest that was not disclosed. We found that the study 
      findings did not support the authors' conclusion that India was a source for
      NDM-1 positive UK patients. Misplaced conclusions had the potential to cause
      unfounded scare and panic.
FAU - Kant, Shashi
AU  - Kant S
AD  - Centre for Community Medicine, AIIMS, New Delhi, India. skant76@gmail.com
FAU - Haldar, Partha
AU  - Haldar P
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Public Health
JT  - Indian journal of public health
JID - 0400673
RN  - EC 3.5.2.6 (beta-Lactamases)
RN  - EC 3.5.2.6 (beta-lactamase NDM-1)
SB  - IM
MH  - Drug Resistance, Bacterial/*genetics
MH  - Electrophoresis, Gel, Pulsed-Field
MH  - Enterobacteriaceae/*genetics/*isolation & purification
MH  - Humans
MH  - India/ethnology
MH  - Risk Factors
MH  - *Travel
MH  - United Kingdom/epidemiology
MH  - beta-Lactamases/*genetics
EDAT- 2011/01/20 06:00
MHDA- 2011/04/13 06:00
CRDT- 2011/01/20 06:00
PHST- 2011/01/20 06:00 [entrez]
PHST- 2011/01/20 06:00 [pubmed]
PHST- 2011/04/13 06:00 [medline]
AID - IndianJPublicHealth_2010_54_3_151_75738 [pii]
AID - 10.4103/0019-557X.75738 [doi]
PST - ppublish
SO  - Indian J Public Health. 2010 Jul-Sep;54(3):151-4. doi: 10.4103/0019-557X.75738.


PMID- 21243924
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20220409
IS  - 1118-4841 (Print)
IS  - 1118-4841 (Linking)
VI  - 14
IP  - 2
DP  - 2010 Jun
TI  - Cultural and ethical challenges of assisted reproductive technologies in the
      management of infertility among the Yoruba of southwestern Nigeria.
PG  - 115-27
AB  - This paper discusses the cultural and ethical issues arising from the use of
      Assisted Reproductive Health Technologies. Twenty-five In-depth interviews were
      conducted with 5 couples of reproductive age who have never conceived or brought 
      pregnancy to term after one year of unprotected intercourse, 4 adult males, 4
      adult females, a gyneacologist, a nurse, a herbalist and 2 religious leaders in
      Ibadan, Nigeria. Content analysis was used for data analysis. Legitimacy of
      children born through ART, religious obligation, patriarchy, polygamy and value
      of children are cultural issues surrounding ARTs while decision making about it, 
      discrimination against children born through ART, psychological problems and loss
      of self esteem, side effects of the technologies and the cost of accessing them
      are the ethical challenges. The findings have methodological implications for
      conducting infertility research in non-western societies.
FAU - Jegede, Ayodele S
AU  - Jegede AS
AD  - Department of Sociology, University of Ibadan, Ibadan, Nigeria.
      sayjegede@yahoo.com
FAU - Fayemiwo, Adetona S
AU  - Fayemiwo AS
LA  - eng
PT  - Journal Article
PL  - Nigeria
TA  - Afr J Reprod Health
JT  - African journal of reproductive health
JID - 9712263
SB  - IM
MH  - Adult
MH  - Attitude of Health Personnel
MH  - *Cultural Characteristics
MH  - Female
MH  - Humans
MH  - *Infertility, Female
MH  - *Infertility, Male
MH  - Interviews as Topic
MH  - Male
MH  - Nigeria
MH  - Pregnancy
MH  - Religion
MH  - Reproductive Techniques, Assisted/*ethics
EDAT- 2011/01/20 06:00
MHDA- 2011/02/25 06:00
CRDT- 2011/01/20 06:00
PHST- 2011/01/20 06:00 [entrez]
PHST- 2011/01/20 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
PST - ppublish
SO  - Afr J Reprod Health. 2010 Jun;14(2):115-27.


PMID- 21243847
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20110119
IS  - 0748-383X (Print)
IS  - 0748-383X (Linking)
VI  - 20
IP  - 2
DP  - 2010
TI  - Enabling responsible public genomics.
PG  - 325-85
AB  - As scientific understandings of genetics advance, researchers require
      increasingly rich datasets that combine genomic data from large numbers of
      individuals with medical and other personal information. Linking individuals'
      genetic data and personal information precludes anonymity and produces medically 
      significant information--a result not contemplated by the established legal and
      ethical conventions governing human genomic research. To pursue the next
      generation of human genomic research and commerce in a responsible fashion,
      scientists, lawyers, and regulators must address substantial new issues,
      including researchers' duties with respect to clinically significant data, the
      challenges to privacy presented by genomic data, the boundary between genomic
      research and commerce, and the practice of medicine. This Article presents a new 
      model for understanding and addressing these new challenges--a "public genomics" 
      premised on the idea that ethically, legally, and socially responsible genomics
      research requires openness, not privacy, as its organizing principle. Responsible
      public genomics combines the data contributed by informed and fully consenting
      information altruists and the research potential of rich datasets in a genomic
      commons that is freely and globally available. This Article examines the risks
      and benefits of this public genomics model in the context of an ambitious genetic
      research project currently under way--the Personal Genome Project. This Article
      also (i) demonstrates that large-scale genomic projects are desirable, (ii)
      evaluates the risks and challenges presented by public genomics research, and
      (iii) determines that the current legal and regulatory regimes restrict
      beneficial and responsible scientific inquiry while failing to adequately protect
      participants. The Article concludes by proposing a modified normative and legal
      framework that embraces and enables a future of responsible public genomics.
FAU - Conley, John M
AU  - Conley JM
AD  - University of North Carolina, Chapel Hill, USA.
FAU - Doerr, Adam K
AU  - Doerr AK
FAU - Vorhaus, Daniel B
AU  - Vorhaus DB
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Health Matrix Clevel
JT  - Health matrix (Cleveland, Ohio : 1991)
JID - 9311154
MH  - Genomics/ethics/legislation & jurisprudence/*organization & administration
MH  - Humans
MH  - Models, Theoretical
MH  - *Social Responsibility
EDAT- 2011/01/20 06:00
MHDA- 2011/02/25 06:00
CRDT- 2011/01/20 06:00
PHST- 2011/01/20 06:00 [entrez]
PHST- 2011/01/20 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
PST - ppublish
SO  - Health Matrix Clevel. 2010;20(2):325-85.


PMID- 21243837
OWN - HMD
STAT- MEDLINE
DCOM- 20110331
LR  - 20110118
IS  - 0961-2025 (Print)
IS  - 0961-2025 (Linking)
VI  - 19
IP  - 5
DP  - 2010
TI  - Freethought, free love and feminism: secularist debates on marriage and sexual
      morality, England c. 1850-1885.
PG  - 775-93
LID - 10.1080/09612025.2010.509162 [doi]
AB  - This article examines the previously unexplored current of Freethinking feminism 
      in the second half of the nineteenth century. Active in the women's movement of
      this period, Freethinking feminists were nonetheless viewed as a liability-an
      attitude that contributed to their exclusion from much of the subsequent
      historiography. Such marginalisation was due not only to their vocal opposition
      to all forms of religion, but also their openness to discussing new ways of
      organising heterosexual relationships. This article focuses on Freethinking
      feminist critiques of marriage and support for free unions. It demonstrates that 
      these issues continued to be debated in the Secularist movement at a time when
      many other radical organisations-including much of the women's movement-kept
      silent on such topics. In this way, Freethinking feminists kept alive the more
      radical and libertarian critiques of traditional sexual morality developed by
      Owenite feminists in the 1830s and 40s. The author argues that the ideology of
      Freethought propelled its adherents to readdress questions of sex within a new
      'Secularist' ethical framework. Fierce debate ensued, yet commitment to freedom
      of discussion ensured that 'unrespectable', libertarian voices were never
      entirely silenced. Freethinking feminism might, then, be viewed as the 'missing
      link' between early nineteenth-century feminist visions of greater sexual freedom
      and the more radical discussions of sexuality and free love that began to emerge 
      at the fin de sicle.
FAU - Schwartz, Laura
AU  - Schwartz L
AD  - St Hugh's College, University of Oxford.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - England
TA  - Womens Hist Rev
JT  - Women's history review
JID - 101504318
MH  - England/ethnology
MH  - *Feminism/history
MH  - Heterosexuality/ethnology/history/physiology/psychology
MH  - History, 19th Century
MH  - Marriage/ethnology/history/legislation & jurisprudence/psychology
MH  - *Morals
MH  - Secularism/history
MH  - *Sexual Behavior/ethnology/history/physiology/psychology
MH  - Social Alienation/psychology
MH  - *Social Change/history
MH  - *Women/education/history/psychology
MH  - Women's Health/ethnology/history
MH  - *Women's Rights/economics/education/history/legislation & jurisprudence
EDAT- 2011/01/20 06:00
MHDA- 2011/04/01 06:00
CRDT- 2011/01/20 06:00
PHST- 2011/01/20 06:00 [entrez]
PHST- 2011/01/20 06:00 [pubmed]
PHST- 2011/04/01 06:00 [medline]
AID - 10.1080/09612025.2010.509162 [doi]
PST - ppublish
SO  - Womens Hist Rev. 2010;19(5):775-93. doi: 10.1080/09612025.2010.509162.


PMID- 21243828
OWN - HMD
STAT- MEDLINE
DCOM- 20110331
LR  - 20191112
IS  - 0952-6951 (Print)
IS  - 0952-6951 (Linking)
VI  - 23
IP  - 4
DP  - 2010
TI  - Alienation, authenticity and the self.
PG  - 21-36
AB  - While many commentators have held that the concept "alienation" is of crucial
      importance when attempting to understand human existence, others have held that
      it is an inherently empty concept that we should abandon. In this article, I
      refute the latters' charge by showing that each conception of "alienation" is
      underpinned by a normative ontological conception of the preferable, or
      authentic, self and show that the concept "alienation" has ethical, existential
      and socio-political uses. From this I conclude that, when properly understood,
      the concept "alienation" can provide us with vital insights into human existence.
FAU - Rae, Gavin
AU  - Rae G
AD  - American Univ., Cairo, Egypt.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - England
TA  - Hist Human Sci
JT  - History of the human sciences
JID - 100967737
MH  - History, 19th Century
MH  - History, 20th Century
MH  - History, 21st Century
MH  - *Human Characteristics
MH  - *Individuality
MH  - Mental Health/history
MH  - Personality
MH  - *Self Concept
MH  - *Social Alienation/psychology
MH  - *Social Behavior/history
EDAT- 2011/01/20 06:00
MHDA- 2011/04/01 06:00
CRDT- 2011/01/20 06:00
PHST- 2011/01/20 06:00 [entrez]
PHST- 2011/01/20 06:00 [pubmed]
PHST- 2011/04/01 06:00 [medline]
AID - 10.1177/0952695110375763 [doi]
PST - ppublish
SO  - Hist Human Sci. 2010;23(4):21-36. doi: 10.1177/0952695110375763.


PMID- 21240949
OWN - NLM
STAT- MEDLINE
DCOM- 20130226
LR  - 20181201
IS  - 1537-5781 (Electronic)
IS  - 1533-8916 (Linking)
VI  - 2010
IP  - 128
DP  - 2010 Winter
TI  - Beyond computer literacy: supporting youth's positive development through
      technology.
PG  - 13-23
LID - 10.1002/yd.371 [doi]
AB  - In a digital era in which technology plays a role in most aspects of a child's
      life, having the competence and confidence to use computers might be a necessary 
      step, but not a goal in itself. Developing character traits that will serve
      children to use technology in a safe way to communicate and connect with others, 
      and providing opportunities for children to make a better world through the use
      of their computational skills, is just as important. The Positive Technological
      Development framework (PTD), a natural extension of the computer literacy and the
      technological fluency movements that have influenced the world of educational
      technology, adds psychosocial, civic, and ethical components to the cognitive
      ones. PTD examines the developmental tasks of a child growing up in our digital
      era and provides a model for developing and evaluating technology-rich youth
      programs. The explicit goal of PTD programs is to support children in the
      positive uses of technology to lead more fulfilling lives and make the world a
      better place. This article introduces the concept of PTD and presents examples of
      the Zora virtual world program for young people that the author developed
      following this framework.
FAU - Bers, Marina Umaschi
AU  - Bers MU
AD  - Eliot-Pearson Department of Child Development, Tufts University.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - New Dir Youth Dev
JT  - New directions for youth development
JID - 101090644
SB  - IM
MH  - *Attitude to Computers
MH  - Child
MH  - *Child Development
MH  - *Computer Literacy/trends
MH  - Computer Systems/statistics & numerical data
MH  - Cooperative Behavior
MH  - Diffusion of Innovation
MH  - *Educational Technology/methods/trends
MH  - Humans
MH  - Models, Theoretical
MH  - Organizational Objectives
MH  - *Problem-Based Learning
MH  - *Program Development/methods
MH  - Program Evaluation
MH  - Social Facilitation
EDAT- 2011/01/18 06:00
MHDA- 2013/02/27 06:00
CRDT- 2011/01/18 06:00
PHST- 2011/01/18 06:00 [entrez]
PHST- 2011/01/18 06:00 [pubmed]
PHST- 2013/02/27 06:00 [medline]
AID - 10.1002/yd.371 [doi]
PST - ppublish
SO  - New Dir Youth Dev. 2010 Winter;2010(128):13-23. doi: 10.1002/yd.371.


PMID- 21240083
OWN - NLM
STAT- MEDLINE
DCOM- 20110310
LR  - 20191210
IS  - 1462-4753 (Print)
IS  - 1462-4753 (Linking)
VI  - 15
IP  - 12
DP  - 2010 Dec
TI  - Exploring the concept of quality care for the person who is dying.
PG  - 588-93
AB  - The concept of good quality care for the patient who is dying is diverse and
      complex. Many of the actions that are being taken to increase the quality of care
      of the dying patient are based around outcome, uniformity of service and
      standardization of process. There are two main areas that are referred to when
      dealing with care of the dying patient; end-of-life care and palliative care.
      High quality end-of-life care is increasingly recognized as an ethical obligation
      of health-care providers, clinicians and organizations, and yet there appears
      little evidence from the patients' perspective. There are many national and local
      initiatives taking place to improve the quality of care people receive towards
      the end of their life. This being said initiatives alone will not achieve good
      quality care and deliver good patient experiences. Only clinicians working at the
      front line can truly influence the way in which quality is improved and good
      experiences delivered.
FAU - Stefanou, Nichola
AU  - Stefanou N
AD  - n.stefanou@nhs.net
FAU - Faircloth, Sandra
AU  - Faircloth S
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Community Nurs
JT  - British journal of community nursing
JID - 9815827
MH  - Advance Care Planning/organization & administration
MH  - Community Health Nursing/*organization & administration
MH  - Critical Pathways/organization & administration
MH  - Health Care Reform/organization & administration
MH  - Humans
MH  - Outcome and Process Assessment, Health Care/organization & administration
MH  - Palliative Care/*organization & administration/psychology
MH  - Patient-Centered Care/organization & administration
MH  - Quality of Health Care/*organization & administration
MH  - State Medicine/*organization & administration
MH  - Terminal Care/*organization & administration/psychology
MH  - United Kingdom
EDAT- 2011/01/18 06:00
MHDA- 2011/03/11 06:00
CRDT- 2011/01/18 06:00
PHST- 2011/01/18 06:00 [entrez]
PHST- 2011/01/18 06:00 [pubmed]
PHST- 2011/03/11 06:00 [medline]
AID - 10.12968/bjcn.2010.15.12.588 [doi]
PST - ppublish
SO  - Br J Community Nurs. 2010 Dec;15(12):588-93. doi: 10.12968/bjcn.2010.15.12.588.


PMID- 21235829
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20220408
IS  - 1466-609X (Electronic)
IS  - 1364-8535 (Linking)
VI  - 14
IP  - 6
DP  - 2010
TI  - Clinical review: idiopathic pulmonary fibrosis acute exacerbations--unravelling
      Ariadne's thread.
PG  - 246
LID - 10.1186/cc9241 [doi]
AB  - Idiopathic pulmonary fibrosis (IPF) is a dreadful, chronic, and irreversibly
      progressive fibrosing disease leading to death in all patients affected, and IPF 
      acute exacerbations constitute the most devastating complication during its
      clinical course. IPF exacerbations are subacute/acute, clinically significant
      deteriorations of unidentifiable cause that usually transform the slow and more
      or less steady disease decline to the unexpected appearance of acute lung
      injury/acute respiratory distress syndrome (ALI/ARDS) ending in death. The
      histological picture is that of diffuse alveolar damage (DAD), which is the
      tissue counterpart of ARDS, upon usual interstitial pneumonia, which is the
      tissue equivalent of IPF. ALI/ARDS and acute interstitial pneumonia share with
      IPF exacerbations the tissue damage pattern of DAD. 'Treatment' with high-dose
      corticosteroids with or without an immunosuppressant proved ineffective and
      represents the coup de grace for these patients. Provision of excellent
      supportive care and the search for and treatment of the 'underlying cause' remain
      the only options. IPF exacerbations require rapid decisions about when and
      whether to initiate mechanical support. Admission to an intensive care unit (ICU)
      is a particular clinical and ethical challenge because of the extremely poor
      outcome. Transplantation in the ICU setting often presents insurmountable
      difficulties.
FAU - Papiris, Spyros A
AU  - Papiris SA
AD  - 2nd Pulmonary Department, Attikon University Hospital, Athens Medical School,
      National and Kapodistrian University of Athens, 1 Rimini Street, 12462, Haidari, 
      Greece. papiris@otenet.gr
FAU - Manali, Effrosyni D
AU  - Manali ED
FAU - Kolilekas, Likurgos
AU  - Kolilekas L
FAU - Kagouridis, Konstantinos
AU  - Kagouridis K
FAU - Triantafillidou, Christina
AU  - Triantafillidou C
FAU - Tsangaris, Iraklis
AU  - Tsangaris I
FAU - Roussos, Charis
AU  - Roussos C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20101222
PL  - England
TA  - Crit Care
JT  - Critical care (London, England)
JID - 9801902
SB  - IM
MH  - Acute Disease
MH  - Acute Lung Injury/etiology/physiopathology/therapy
MH  - Animals
MH  - Humans
MH  - Idiopathic Pulmonary Fibrosis/complications/*physiopathology/*therapy
MH  - Intensive Care Units
MH  - Respiration, Artificial/methods
MH  - Respiratory Distress Syndrome/etiology/physiopathology/therapy
PMC - PMC3220036
EDAT- 2011/01/18 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/01/18 06:00
PHST- 2011/01/18 06:00 [entrez]
PHST- 2011/01/18 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - cc9241 [pii]
AID - 10.1186/cc9241 [doi]
PST - ppublish
SO  - Crit Care. 2010;14(6):246. doi: 10.1186/cc9241. Epub 2010 Dec 22.


PMID- 21235034
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110711
LR  - 20191027
IS  - 1573-6814 (Electronic)
IS  - 1389-9333 (Linking)
VI  - 11
IP  - 4
DP  - 2010 Nov
TI  - WHO Guiding Principles on Human Cell, Tissue and Organ Transplantation.
PG  - 413-9
AB  - In May 2010, the Sixty-third World Health Assembly Resolution WHA63.22 endorsed
      the WHO Guiding Principles, updated in the light of changes in practices and
      attitudes regarding organ and tissue transplantation. The Guiding Principles are 
      intended to provide an orderly, ethical and acceptable framework for the
      procurement and transplantation of human cells, tissues and organs for
      therapeutic purposes. Each jurisdiction will determine the means of implementing 
      these WHO Guiding Principles.They preserve the essential points of the 1991
      version while incorporating new provisions in response to current trends in
      transplantation, particularly the protection of the living donor, and the
      increasing use of human cells and tissues. The Guiding Principles stress the
      necessity of documentation and transparency, both for quality management purposes
      and to justify the confidence of patients, clinicians and the community at large 
      in donation and transplantation services.
CN  - Sixty-Third World Health Assembly, World Health Organization
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Cell Tissue Bank
JT  - Cell and tissue banking
JID - 100965121
RPF - Transplantation. 2010 Aug 15;90(3):229-33. PMID: 20664493
EDAT- 2011/01/15 06:00
MHDA- 2011/01/15 06:01
CRDT- 2011/01/15 06:00
PHST- 2011/01/15 06:00 [entrez]
PHST- 2011/01/15 06:00 [pubmed]
PHST- 2011/01/15 06:01 [medline]
AID - 10.1007/s10561-010-9226-0 [doi]
PST - ppublish
SO  - Cell Tissue Bank. 2010 Nov;11(4):413-9. doi: 10.1007/s10561-010-9226-0.


PMID- 21229905
OWN - NLM
STAT- MEDLINE
DCOM- 20110216
LR  - 20110114
IS  - 0883-5381 (Print)
IS  - 0883-5381 (Linking)
VI  - 25
IP  - 6
DP  - 2010 Nov-Dec
TI  - The ethics of telemedicine. Unique nature of virtual encounters calls for special
      sensitivities.
PG  - 50-3
FAU - Nelson, William A
AU  - Nelson WA
AD  - Dartmouth Medical School, Hanover, NH, USA. william.a.nelson@dartmouth.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Healthc Exec
JT  - Healthcare executive
JID - 8612808
MH  - Humans
MH  - Rural Population
MH  - Telemedicine/*ethics
MH  - United States
MH  - *User-Computer Interface
EDAT- 2011/01/15 06:00
MHDA- 2011/02/17 06:00
CRDT- 2011/01/15 06:00
PHST- 2011/01/15 06:00 [entrez]
PHST- 2011/01/15 06:00 [pubmed]
PHST- 2011/02/17 06:00 [medline]
PST - ppublish
SO  - Healthc Exec. 2010 Nov-Dec;25(6):50-3.


PMID- 21229855
OWN - NLM
STAT- MEDLINE
DCOM- 20110201
LR  - 20110114
IS  - 0029-6570 (Print)
IS  - 0029-6570 (Linking)
VI  - 25
IP  - 14
DP  - 2010 Dec 8-14
TI  - Withholding or withdrawing nutrition at the end of life.
PG  - 43-6
AB  - Food and fluids are essential to life and play important social and psychological
      roles. Despite increased understanding of the appropriate use of artificial
      nutrition, its use is particularly challenging for professionals and families.
      This may be complicated by misunderstanding about its likely benefits and
      burdens, concern about patient suffering and ambivalence regarding the moral
      status of feeding. When patients are unable to meet their fluid and nutritional
      needs orally it is necessary to consider whether artificial nutrition is
      appropriate. Therapeutic decisions should be based on a clear understanding of
      the overall goals of care and the application of ethical principles that can
      provide a framework to guide practice.
FAU - Holmes, Susan
AU  - Holmes S
AD  - Faculty of Health and Social Care, Canterbury Christ Church University,
      Canterbury. susan.holmes@canterbury.ac.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Stand
JT  - Nursing standard (Royal College of Nursing (Great Britain) : 1987)
JID - 9012906
MH  - Critical Pathways/ethics
MH  - Decision Making/ethics
MH  - Fluid Therapy/*ethics/methods
MH  - Hippocratic Oath
MH  - Humans
MH  - Informed Consent/ethics
MH  - Nutritional Support/*ethics/methods
MH  - Patient Advocacy/*ethics
MH  - Patient Selection
MH  - Principle-Based Ethics
MH  - Terminal Care/*ethics/methods
MH  - Withholding Treatment/*ethics
EDAT- 2011/01/15 06:00
MHDA- 2011/02/02 06:00
CRDT- 2011/01/15 06:00
PHST- 2011/01/15 06:00 [entrez]
PHST- 2011/01/15 06:00 [pubmed]
PHST- 2011/02/02 06:00 [medline]
AID - 10.7748/ns2010.12.25.14.43.c8154 [doi]
PST - ppublish
SO  - Nurs Stand. 2010 Dec 8-14;25(14):43-6. doi: 10.7748/ns2010.12.25.14.43.c8154.


PMID- 21229839
OWN - NLM
STAT- MEDLINE
DCOM- 20110324
LR  - 20190923
IS  - 1547-1896 (Print)
IS  - 0893-7400 (Linking)
VI  - 23
IP  - 12
DP  - 2010 Dec
TI  - Is it ethical to substitute restraints for adequate treatment resources?
PG  - 62, 64
FAU - Godfrey, Alexandra
AU  - Godfrey A
AD  - St. Joseph's Mercy Hospital, Ypsilanti, Michigan, USA.
FAU - Bushardt, Reamer L
AU  - Bushardt RL
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - JAAPA
JT  - JAAPA : official journal of the American Academy of Physician Assistants
JID - 9513102
MH  - Adult
MH  - Alcoholic Intoxication/*psychology/*therapy
MH  - Anxiety Disorders/*etiology/prevention & control
MH  - Emergency Service, Hospital/*organization & administration
MH  - Female
MH  - Humans
MH  - Restraint, Physical/adverse effects/*ethics/*psychology
EDAT- 2011/01/15 06:00
MHDA- 2011/03/25 06:00
CRDT- 2011/01/15 06:00
PHST- 2011/01/15 06:00 [entrez]
PHST- 2011/01/15 06:00 [pubmed]
PHST- 2011/03/25 06:00 [medline]
AID - 10.1097/01720610-201012000-00013 [doi]
PST - ppublish
SO  - JAAPA. 2010 Dec;23(12):62, 64. doi: 10.1097/01720610-201012000-00013.


PMID- 21229779
OWN - NLM
STAT- MEDLINE
DCOM- 20110301
LR  - 20110113
IS  - 0253-0465 (Print)
IS  - 0253-0465 (Linking)
VI  - 103
IP  - 10
DP  - 2010
TI  - [Ethics today--disparity of performance and returns].
PG  - 2
FAU - Baumgartner, Adrian
AU  - Baumgartner A
LA  - ger
PT  - Journal Article
TT  - Ethik heute--Missverhaltnis Leistung und Ertrag.
PL  - Switzerland
TA  - Krankenpfl Soins Infirm
JT  - Krankenpflege. Soins infirmiers
JID - 8000153
MH  - *Ethics, Nursing
MH  - Evidence-Based Nursing/trends
MH  - Humans
MH  - Nursing Care/*standards
MH  - Quality of Life
EDAT- 2011/01/15 06:00
MHDA- 2011/03/02 06:00
CRDT- 2011/01/15 06:00
PHST- 2011/01/15 06:00 [entrez]
PHST- 2011/01/15 06:00 [pubmed]
PHST- 2011/03/02 06:00 [medline]
PST - ppublish
SO  - Krankenpfl Soins Infirm. 2010;103(10):2.


PMID- 21226646
OWN - NLM
STAT- MEDLINE
DCOM- 20110503
LR  - 20191210
IS  - 1369-1627 (Electronic)
IS  - 0954-0261 (Linking)
VI  - 22
IP  - 6
DP  - 2010
TI  - Viewing Uganda's mental health system through a human rights lens.
PG  - 578-88
LID - 10.3109/09540261.2010.536151 [doi]
AB  - There has been increased global concern about the human rights violations
      experienced by people with mental disorders. The aim of this study was to analyse
      Uganda's mental health care system through a human rights lens. A survey of the
      existing mental health system in Uganda was conducted using the WHO Assessment
      Instrument for Mental Health Systems. In addition, 62 interviews and six focus
      groups were conducted with a broad range of mental health stakeholders at the
      national and district levels. Despite possessing a draft mental health policy
      that is in line with many international human rights standards, Uganda's mental
      health system inadequately promotes and protects, and frequently violates the
      human rights of people with mental disorders. The mental health legislation is
      offensive and stigmatizing. It is common for people accessing mental health
      services to encounter physical and emotional abuse and an inadequate quality of
      care. Mental health services are inequitably distributed. Within Ugandan society,
      people with mental disorders also frequently experience widespread stigma and
      discrimination, and limited support. Promoting and protecting the rights of
      people with mental disorders has ethical and public health imperatives. A number 
      of policy, legislative and service development initiatives are required.
FAU - Cooper, Sara
AU  - Cooper S
AD  - Department of Psychiatry and Mental Health, University of Cape Town, South
      Africa. SD.Cooper@uct.ac.za
FAU - Ssebunnya, Joshua
AU  - Ssebunnya J
FAU - Kigozi, Fred
AU  - Kigozi F
FAU - Lund, Crick
AU  - Lund C
FAU - Flisher, Alan
AU  - Flisher A
CN  - The Mhapp Research Programme Consortium
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int Rev Psychiatry
JT  - International review of psychiatry (Abingdon, England)
JID - 8918131
SB  - IM
MH  - Health Policy/*legislation & jurisprudence
MH  - Human Rights/*standards
MH  - Human Rights Abuses/*prevention & control
MH  - Humans
MH  - *Mental Health Services/ethics/legislation & jurisprudence
MH  - Mentally Ill Persons/*legislation & jurisprudence
MH  - Prejudice
MH  - Professional Misconduct
MH  - Quality Indicators, Health Care
MH  - Social Isolation
MH  - Social Stigma
EDAT- 2011/01/14 06:00
MHDA- 2011/05/04 06:00
CRDT- 2011/01/14 06:00
PHST- 2011/01/14 06:00 [entrez]
PHST- 2011/01/14 06:00 [pubmed]
PHST- 2011/05/04 06:00 [medline]
AID - 10.3109/09540261.2010.536151 [doi]
PST - ppublish
SO  - Int Rev Psychiatry. 2010;22(6):578-88. doi: 10.3109/09540261.2010.536151.


PMID- 21226417
OWN - NLM
STAT- MEDLINE
DCOM- 20110202
LR  - 20110113
IS  - 0729-2759 (Print)
IS  - 0729-2759 (Linking)
VI  - 18
IP  - 3
DP  - 2010 Nov
TI  - An ethical dilemma: should recommending antenatal expressing and storing of
      colostrum continue?
PG  - 5-7
FAU - Cox, Sue
AU  - Cox S
AD  - sue_cox@bigpond.net.au
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Breastfeed Rev
JT  - Breastfeeding review : professional publication of the Nursing Mothers'
      Association of Australia
JID - 9616903
MH  - Breast Feeding
MH  - *Colostrum/physiology
MH  - Diabetes Mellitus, Type 1/physiopathology
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Lactation Disorders/physiopathology
MH  - Pregnancy
MH  - Prenatal Care/*ethics
MH  - Randomized Controlled Trials as Topic
EDAT- 2011/01/14 06:00
MHDA- 2011/02/03 06:00
CRDT- 2011/01/14 06:00
PHST- 2011/01/14 06:00 [entrez]
PHST- 2011/01/14 06:00 [pubmed]
PHST- 2011/02/03 06:00 [medline]
PST - ppublish
SO  - Breastfeed Rev. 2010 Nov;18(3):5-7.


PMID- 21226411
OWN - NLM
STAT- MEDLINE
DCOM- 20110203
LR  - 20151119
IS  - 1497-3715 (Print)
IS  - 1497-3715 (Linking)
VI  - 21
IP  - 4
DP  - 2010 Winter
TI  - Novice nurses' first death in critical care.
PG  - 26-36
AB  - BACKGROUND: The curative focus of critical care and the advanced technology may
      overshadow the fact that critically ill patients die. Research investigating
      critical care nurses involvement with death has predominately focused on
      experienced nurses, but these findings may not be applicable to novice nurses.
      Increasingly, novice nurses are beginning their careers in critical care and
      there is minimal research describing their experiences with death. PURPOSE: To
      explore the experiences of novice nurses with their first patient death in
      critical care. METHOD: Approval was received by the University of Alberta Health 
      Research Ethics Board and the health region's Nursing Division Administration to 
      conduct a qualitative research study. Five nurses, employed in a medical-surgical
      intensive care unit, participated in the study. Data collection involved an
      unstructured interview with each participant. FINDINGS: Analysis of the data
      revealed five themes: anticipating death, transition from life to death, the
      moment of death, being with the family, and carrying on. These findings are
      discussed with implications for academic and clinical settings and suggestions
      for future nursing research.
FAU - Thompson, Gwen
AU  - Thompson G
AD  - Misericordia Hospital-Covenant Health, Edmonton, AB.
FAU - Austin, Wendy
AU  - Austin W
FAU - Profetto-McGrath, Joanne
AU  - Profetto-McGrath J
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Dynamics
JT  - Dynamics (Pembroke, Ont.)
JID - 100955578
MH  - *Adaptation, Psychological
MH  - Alberta
MH  - *Attitude of Health Personnel
MH  - *Attitude to Death
MH  - Critical Care/organization & administration/*psychology
MH  - Family/psychology
MH  - Female
MH  - Funeral Rites
MH  - Humans
MH  - Interprofessional Relations
MH  - Nurse-Patient Relations
MH  - Nursing Methodology Research
MH  - Nursing Staff, Hospital/education/organization & administration/*psychology
MH  - Postmortem Changes
MH  - Professional-Family Relations
MH  - Qualitative Research
MH  - Social Support
MH  - Surveys and Questionnaires
MH  - Terminal Care/organization & administration/*psychology
MH  - Withholding Treatment
EDAT- 2011/01/14 06:00
MHDA- 2011/02/04 06:00
CRDT- 2011/01/14 06:00
PHST- 2011/01/14 06:00 [entrez]
PHST- 2011/01/14 06:00 [pubmed]
PHST- 2011/02/04 06:00 [medline]
PST - ppublish
SO  - Dynamics. 2010 Winter;21(4):26-36.


PMID- 21224969
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20220330
IS  - 0976-2817 (Electronic)
IS  - 0019-5049 (Linking)
VI  - 54
IP  - 6
DP  - 2010 Nov
TI  - Immediate extubation versus standard postoperative ventilation: Our experience in
      on pump open heart surgery.
PG  - 525-30
LID - 10.4103/0019-5049.72641 [doi]
AB  - Elective postoperative ventilation in patients undergoing "on pump" open heart
      surgery has been a standard practice. Ultra fast-track extubation in the
      operating room is now an accepted technique for "off pump" coronary artery bypass
      grafting. We tried to incorporate these experiences in on pump open heart surgery
      and compare the haemodynamic and respiratory parameters in the immediate
      postoperative period, in patients on standard postoperative ventilation for 8-12 
      hours. After ethical committee's approval and informed consent were obtained, 72 
      patients, between 28 and 45 years of age, undergoing on pump open heart surgery, 
      were selected for our study. We followed same standard anaesthetic,
      cardiopulmonary bypass (CPB) and cardioplegic protocol. Thirty-six patients
      (Group E) were randomly allocated for immediate extubation following operation,
      after fulfillment of standard extubation criteria. Those who failed to meet these
      criteria were not extubated and were excluded from the study. The remaining 36
      patients (Group V) were electively ventilated and extubated after 8-12 hours.
      Standard monitoring for on pump open heart surgery, including bispectral index
      was done. The demographic data, surgical procedures, preoperative parameters,
      aortic cross clamp and cardiopulmonary bypass times were comparable in both the
      groups. Extubation was possible in more than 88% of cases (n=32 out of 36 cases) 
      in Group E and none required reintubation for respiratory insufficiency.
      Respiratory, haemodynamic parameters and postoperative complications were
      comparable in both the groups in the postoperative period. Therefore, we can
      safely conclude that immediate extubation in the operating room after on pump
      open heart surgery is an alternative acceptable method to avoid postoperative
      ventilation and its related complications in selected patients.
FAU - Gangopadhyay, Srikanta
AU  - Gangopadhyay S
AD  - Asansol Subdivisional Hospital, Asansol, West Bengal, India.
FAU - Acharjee, Amita
AU  - Acharjee A
FAU - Nayak, Sushil Kumar
AU  - Nayak SK
FAU - Dawn, Satrajit
AU  - Dawn S
FAU - Piplai, Gautam
AU  - Piplai G
FAU - Gupta, Krishna
AU  - Gupta K
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Anaesth
JT  - Indian journal of anaesthesia
JID - 0013243
PMC - PMC3016572
OTO - NOTNLM
OT  - Haemodynamic parameters
OT  - immediate extubation
OT  - off pump
OT  - on pump
OT  - postoperative complication
OT  - postoperative ventilation
EDAT- 2011/01/13 06:00
MHDA- 2011/01/13 06:01
CRDT- 2011/01/13 06:00
PHST- 2011/01/13 06:00 [entrez]
PHST- 2011/01/13 06:00 [pubmed]
PHST- 2011/01/13 06:01 [medline]
AID - 10.4103/0019-5049.72641 [doi]
PST - ppublish
SO  - Indian J Anaesth. 2010 Nov;54(6):525-30. doi: 10.4103/0019-5049.72641.


PMID- 21224947
OWN - NLM
STAT- MEDLINE
DCOM- 20110422
LR  - 20211020
IS  - 1526-6702 (Electronic)
IS  - 0730-2347 (Linking)
VI  - 37
IP  - 6
DP  - 2010
TI  - Ethical issues in surgical trials and in the diffusion of innovative therapies.
PG  - 685-6
FAU - Brody, Baruch A
AU  - Brody BA
AD  - Center for Medical Ethics & Health Policy, Baylor College of Medicine, Houston,
      Texas 77030, USA. bbrody@bcm.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Tex Heart Inst J
JT  - Texas Heart Institute journal
JID - 8214622
SB  - IM
MH  - Comprehension
MH  - *Diffusion of Innovation
MH  - Evidence-Based Medicine/*ethics
MH  - Humans
MH  - Informed Consent/ethics
MH  - Placebo Effect
MH  - Randomized Controlled Trials as Topic/*ethics/methods
MH  - Research Design
MH  - Surgical Procedures, Operative/*ethics
MH  - Therapies, Investigational/*ethics
MH  - Treatment Outcome
PMC - PMC3014114
EDAT- 2011/01/13 06:00
MHDA- 2011/04/26 06:00
CRDT- 2011/01/13 06:00
PHST- 2011/01/13 06:00 [entrez]
PHST- 2011/01/13 06:00 [pubmed]
PHST- 2011/04/26 06:00 [medline]
PST - ppublish
SO  - Tex Heart Inst J. 2010;37(6):685-6.


PMID- 21222208
OWN - NLM
STAT- MEDLINE
DCOM- 20160423
LR  - 20211203
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 695
DP  - 2010
TI  - Reprogramming of somatic cells to pluripotency.
PG  - 215-24
LID - 10.1007/978-1-4419-7037-4_14 [doi]
AB  - Reprogramming of somatic cells into pluripotent stem cells has been achieved by
      introducing four transcription factors, Sox2, Oct3/4, Klf4 and c-Myc, in 2006.
      These induced pluripotent stem (iPS) cells have raised hopes for a new era of
      regenerative medicine because they can avoid the ethical problems and innate
      immune rejection associated with embryonic stem cells. However, the underlying
      molecular mechanism of reprogramming still remains unclear. In this chapter, we
      look back at the history of reprogramming research ranging from amphibian to
      mammalian cells and discuss our recent understanding of the molecular mechanisms 
      of reprogramming and the possibility of utilizing reprogrammed cells for
      regenerative medicine.
FAU - Nakagawa, Masato
AU  - Nakagawa M
AD  - Center for iPS Research and Application Institute for Integrated Cell-Material
      Sciences, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, 
      Japan, nakagawa@cira.kyoto-u.ac.jp.
FAU - Yamanaka, Shinya
AU  - Yamanaka S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 0 (KLF4 protein, human)
RN  - 0 (Kruppel-Like Factor 4)
RN  - 0 (Octamer Transcription Factor-3)
RN  - 0 (SOXB1 Transcription Factors)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Cellular Reprogramming
MH  - Humans
MH  - *Induced Pluripotent Stem Cells
MH  - Kruppel-Like Factor 4
MH  - *Octamer Transcription Factor-3/genetics
MH  - Pluripotent Stem Cells
MH  - SOXB1 Transcription Factors
MH  - Transcription Factors/genetics
EDAT- 2011/01/12 06:00
MHDA- 2016/04/24 06:00
CRDT- 2011/01/12 06:00
PHST- 2011/01/12 06:00 [entrez]
PHST- 2011/01/12 06:00 [pubmed]
PHST- 2016/04/24 06:00 [medline]
AID - 10.1007/978-1-4419-7037-4_14 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2010;695:215-24. doi: 10.1007/978-1-4419-7037-4_14.


PMID- 21222068
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140612
LR  - 20161021
IS  - 0035-1776 (Print)
IS  - 0035-1776 (Linking)
VI  - 131
IP  - 4
DP  - 2010
TI  - [The significance of Ptolemy's Almagest for its early readers].
PG  - 495-521
AB  - The paper explores the historical reasons why Ptolemy's Almagest was cultivated
      in Antiquity as a legitimate part of ancient culture. It tries to elucidate first
      the precise nature of Ptolemy's project in the Almagest, its relation to ethics
      as well as to the particular conception that Ptolemy had of mathematics. It then 
      proposes an explanation for the fact that this treatise, both in Ptolemy's period
      and afterwards, was studied within the milieu of ancient astrologers.
FAU - Bernard, Alain
AU  - Bernard A
AD  - , 78, boulevard Arago, F-75013, Paris, France, alainguy.bernard@orange.fr.
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - La valeur de l'Almageste de Ptolemee aux yeux de ses premiers lecteurs Die
      bedeutung von Ptolemaus' Almagest fur seine fruhen leser El valor de Almagesto de
      Ptolomeo visto por sus primeros lectores << >>
PL  - France
TA  - Rev Synth
JT  - Revue de synthese
JID - 8711586
EDAT- 2011/01/12 06:00
MHDA- 2011/01/12 06:01
CRDT- 2011/01/12 06:00
PHST- 2011/01/12 06:00 [entrez]
PHST- 2011/01/12 06:00 [pubmed]
PHST- 2011/01/12 06:01 [medline]
AID - 10.1007/s11873-010-0132-1 [doi]
PST - ppublish
SO  - Rev Synth. 2010;131(4):495-521. doi: 10.1007/s11873-010-0132-1.


PMID- 21221494
OWN - NLM
STAT- MEDLINE
DCOM- 20110506
LR  - 20191210
IS  - 0037-5675 (Print)
IS  - 0037-5675 (Linking)
VI  - 51
IP  - 12
DP  - 2010 Dec
TI  - Publication ethics and scientific misconduct.
PG  - 908-12
AB  - To maintain the readers' trust and to uphold the journal's reputation, it is
      paramount for the entire research, peer reviewer and publication process to
      follow ethical principles and decisions. Studies involving humans, animals,
      medical records and human tissues/organs need to be conducted ethically, and the 
      appropriate approvals obtained. The privacy and confidentiality of patients,
      authors and reviewers should be respected. When required, rights and permissions 
      should be sought. Common forms of scientific misconduct include misappropriation 
      of ideas, violation of generally accepted research practices, failure to comply
      with legislative and regulatory requirements, falsification of data, and
      inappropriate behaviour in relation to misconduct. Authors can expect editorial
      action to be taken, should duplicate publication, plagiarism and other forms of
      scientific misconduct be attempted or detected.
FAU - Peh, W C G
AU  - Peh WC
AD  - Singapore Medical Journal, 2 College Road, Singapore 169850.
      wilfred.peh@gmail.com
FAU - Ng, K H
AU  - Ng KH
LA  - eng
PT  - Journal Article
PL  - Singapore
TA  - Singapore Med J
JT  - Singapore medical journal
JID - 0404516
SB  - IM
MH  - Confidentiality/ethics
MH  - Duplicate Publications as Topic
MH  - Editorial Policies
MH  - Humans
MH  - Peer Review/ethics
MH  - Periodicals as Topic/ethics
MH  - Plagiarism
MH  - Publications/*ethics
MH  - *Scientific Misconduct/ethics
EDAT- 2011/01/12 06:00
MHDA- 2011/05/07 06:00
CRDT- 2011/01/12 06:00
PHST- 2011/01/12 06:00 [entrez]
PHST- 2011/01/12 06:00 [pubmed]
PHST- 2011/05/07 06:00 [medline]
PST - ppublish
SO  - Singapore Med J. 2010 Dec;51(12):908-12.


PMID- 21220204
OWN - NLM
STAT- MEDLINE
DCOM- 20110705
LR  - 20110315
IS  - 1096-7206 (Electronic)
IS  - 1096-7192 (Linking)
VI  - 102
IP  - 4
DP  - 2011 Apr
TI  - Experience over fifteen years with a protocol for predictive testing for
      Huntington disease.
PG  - 494-504
LID - 10.1016/j.ymgme.2010.12.001 [doi]
AB  - OBJECTIVE: To compile a comprehensive profile of the participants who had
      predictive testing from Huntington disease (HD) between 1994 and 2008 in
      Montreal, Canada. METHOD: This is a retrospective cohort study. The predictive
      testing protocol consisted of a telephone interview to give information about
      predictive testing and collect demographic data; a psychological assessment and
      counseling session; a session focused on medical and family history of HD; a
      session reserved for genetic counseling; a session where results were given to
      participants; and a follow-up telephone interview. RESULTS: A total of 181
      applicants requested presymptomatic testing. 135 applicants (77 women and 58 men)
      completed the protocol and received test results while 40 withdrew. Of the
      latter, 3 manifested symptoms of the disease and were referred to a neurologist
      or psychiatrist, and 3 had previously been tested by linkage analysis.
      Participants usually mentioned more than one reason for requesting predictive
      testing but the most frequent was to put an end to uncertainty concerning their
      risk of illness. The proportion of positive and negatives test results was 40%
      and 54.1% respectively, significantly different from the expected 50% (p<0.01).
      Prenatal testing was not frequently requested. CONCLUSION: All the participants
      expressed satisfaction regarding their decision to be tested. None to our
      knowledge had a catastrophic reaction (major depressive disorder or psychiatric
      hospitalization, declared suicide attempt or suicide). Our study highlights that 
      preparation for receiving test results is a psychologically complex process for
      which appropriate support in a timely fashion is critical. We feel that a
      cautious and ethical case by case approach remains essential and that high
      standards of testing should be maintained because of the far reaching impact of
      test results.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Dufrasne, Suzanne
AU  - Dufrasne S
AD  - The Hess B and Diane Finestone Laboratory in Memory of Jacob and Jenny Finestone,
      Montreal, Quebec, Canada.
FAU - Roy, Madeleine
AU  - Roy M
FAU - Galvez, Maria
AU  - Galvez M
FAU - Rosenblatt, David S
AU  - Rosenblatt DS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101213
PL  - United States
TA  - Mol Genet Metab
JT  - Molecular genetics and metabolism
JID - 9805456
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Clinical Protocols
MH  - Female
MH  - Genetic Counseling
MH  - *Genetic Testing
MH  - Humans
MH  - Huntington Disease/*diagnosis/psychology
MH  - Interview, Psychological
MH  - Male
MH  - Middle Aged
MH  - Patient Satisfaction
MH  - Retrospective Studies
MH  - Truth Disclosure
MH  - Young Adult
EDAT- 2011/01/12 06:00
MHDA- 2011/07/06 06:00
CRDT- 2011/01/12 06:00
PHST- 2010/12/03 00:00 [received]
PHST- 2010/12/03 00:00 [accepted]
PHST- 2011/01/12 06:00 [entrez]
PHST- 2011/01/12 06:00 [pubmed]
PHST- 2011/07/06 06:00 [medline]
AID - S1096-7192(10)00561-5 [pii]
AID - 10.1016/j.ymgme.2010.12.001 [doi]
PST - ppublish
SO  - Mol Genet Metab. 2011 Apr;102(4):494-504. doi: 10.1016/j.ymgme.2010.12.001. Epub 
      2010 Dec 13.


PMID- 21219820
OWN - NLM
STAT- MEDLINE
DCOM- 20110429
LR  - 20180126
IS  - 2444-054X (Electronic)
IS  - 0009-7411 (Linking)
VI  - 78
IP  - 5
DP  - 2010 Sep-Oct
TI  - Quality of medical care and patient surgical safety: medical error, malpractice
      and professional liability.
PG  - 456-62
AB  - BACKGROUND: over time, a significant number of definitions and concepts on
      quality of care have been identified. This study focuses on quality of care from 
      the perspective of medical patients. DISCUSSION: quality of medical care includes
      different areas: opportunity, professional qualifications, safety, respect for
      ethical principles of medical practice and satisfaction with care outcomes. In
      this regard, at the Conamed (National Commission for Medical Arbitration), 8062
      complaints have been followed, analyzed and completed between June 1996 and
      December 2008: in 16.8% of the complaints there were insufficient data to
      determine whether or not there was evidence of malpractice; 20.8% of the
      complaints had evidence of malpractice and in 62.4% of complaints the existence
      of good practice was determined according to the lex artis. Among the surgical
      specialties with the highest malpractice cases were the following: general
      surgery, gynecology, orthopedics, ophthalmology, emergency surgery, urology and
      traumatology. CONCLUSIONS: acknowledgment of the concept of quality of health
      care provides a starting point to determine the source of errors, malpractice and
      professional responsibility in order to resolve and prevent them. Conamed offers 
      alternative means for conflict resolution related to physician-patient
      relationship by means of conciliation and arbitration, favoring patient and
      family, as well as the medical profession.
FAU - Aguirre-Gas, Hector Gerardo
AU  - Aguirre-Gas HG
AD  - Comision Nacional de Arbitraje Medico, Mexico, D. F., Mexico.
      haguirregas@conamed.gob.mx
FAU - Zavala-Villavicencio, Jesus Antonio
AU  - Zavala-Villavicencio JA
FAU - Hernandez-Torres, Francisco
AU  - Hernandez-Torres F
FAU - Fajardo-Dolci, German
AU  - Fajardo-Dolci G
LA  - eng
LA  - spa
PT  - Journal Article
PL  - Mexico
TA  - Cir Cir
JT  - Cirugia y cirujanos
JID - 0372736
SB  - IM
MH  - Humans
MH  - *Liability, Legal
MH  - *Malpractice
MH  - *Medical Errors
MH  - *Quality of Health Care
EDAT- 2011/01/12 06:00
MHDA- 2011/04/30 06:00
CRDT- 2011/01/12 06:00
PHST- 2011/01/12 06:00 [entrez]
PHST- 2011/01/12 06:00 [pubmed]
PHST- 2011/04/30 06:00 [medline]
PST - ppublish
SO  - Cir Cir. 2010 Sep-Oct;78(5):456-62.


PMID- 21217998
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20220318
IS  - 1998-3735 (Electronic)
IS  - 0973-1075 (Linking)
VI  - 16
IP  - 3
DP  - 2010 Sep
TI  - Palliative cancer care ethics: principles and challenges in the Indian setting.
PG  - 107-10
LID - 10.4103/0973-1075.73639 [doi]
AB  - Palliative cancer treatment is a system of care that seeks to relieve suffering
      in patients with progressive cancer. Given the intractable symptoms with which
      certain malignancies manifest, palliative care offers a practical approach
      towards improving the patient's quality of life. However, there are an array of
      ethical issues associated with this treatment strategy such as particular methods
      of pain relief, a reliable assessment of suffering, autonomy, and
      multi-specialist care. While these principles are important to increase and
      improve the network of palliative care, the resource-poor Indian environments
      present numerous barriers for these principles to be practically applied. As the 
      infrastructure of comprehensive cancer centers develop, paralleled with an
      increase in training of palliative care professionals, significant improvements
      need to be made in order to elevate the status of palliative cancer care in
      India.
FAU - Mudigonda, Tejaswi
AU  - Mudigonda T
AD  - National Institutes of Health, National Cancer Institute, Surgery Branch,
      Building 10 Hatfield CRC, Bethesda, MD 20892.
FAU - Mudigonda, Parvathi
AU  - Mudigonda P
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Indian J Palliat Care
JT  - Indian journal of palliative care
JID - 101261221
PMC - PMC3012231
OTO - NOTNLM
OT  - Cancer care
OT  - Comprehensive cancer center
OT  - Palliative care
OT  - Palliative ethics
EDAT- 2011/01/11 06:00
MHDA- 2011/01/11 06:01
CRDT- 2011/01/11 06:00
PHST- 2011/01/11 06:00 [entrez]
PHST- 2011/01/11 06:00 [pubmed]
PHST- 2011/01/11 06:01 [medline]
AID - 10.4103/0973-1075.73639 [doi]
PST - ppublish
SO  - Indian J Palliat Care. 2010 Sep;16(3):107-10. doi: 10.4103/0973-1075.73639.


PMID- 21217895
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 0974-7842 (Electronic)
IS  - 0974-620X (Linking)
VI  - 3
IP  - 2
DP  - 2010 May
TI  - Do I have an ethical dilemma?
PG  - 49-50
LID - 10.4103/0974-620X.64226 [doi]
FAU - Levin, Alex V
AU  - Levin AV
AD  - Pediatric Ophthalmology and Ocular Genetics, Wills Eye Institute, Thomas
      Jefferson University, Philadelphia, Pennsylvania, USA.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Oman J Ophthalmol
JT  - Oman journal of ophthalmology
JID - 101519430
PMC - PMC3003850
EDAT- 2011/01/11 06:00
MHDA- 2011/01/11 06:01
CRDT- 2011/01/11 06:00
PHST- 2011/01/11 06:00 [entrez]
PHST- 2011/01/11 06:00 [pubmed]
PHST- 2011/01/11 06:01 [medline]
AID - 10.4103/0974-620X.64226 [doi]
PST - ppublish
SO  - Oman J Ophthalmol. 2010 May;3(2):49-50. doi: 10.4103/0974-620X.64226.


PMID- 21213997
OWN - NLM
STAT- MEDLINE
DCOM- 20110216
LR  - 20110110
IS  - 0226-8841 (Print)
IS  - 0226-8841 (Linking)
VI  - 31
IP  - 2
DP  - 2010 Nov
TI  - Suicide, Canadian law, and Exit International's "peaceful pill".
PG  - 37-52
AB  - Australia's Exit International ("Exit") is probably the most visible and
      controversial right-to-die organization in the world. Founded by Dr. Philip
      Nitschke, Exit is known for do-it-yourself ("DIY") suicide workshops and a book
      banned in Australia: The Peaceful Pill Handbook. In 2009, Exit held its first
      workshop in Canada. Due to legal concerns, the Vancouver Public Library reneged
      on a commitment to give Exit a venue, so the workshop proceeded in the sanctuary 
      of a church hall. This article summarizes the history of suicide law in Canada
      and gives an overview of the emerging DIY movement. A case report describes how a
      Canadian woman studied Exit's literature and learned how to import veterinary
      pentobarbital. In accordance with Exit's information, she ended her life. Ethical
      and legal implications for researching DIY suicide are discussed and it is argued
      that prohibition contributes to an undesirable situation of uncontrolled and
      unregulated suicide. Whether they are prohibited, permitted, or tolerated,
      suicide and assisted suicide are controversial. Their legal treatment in Canada
      is conflicting because suicide is not a crime but it is a serious offense to
      assist, encourage, or counsel someone to suicide. Individuals can lawfully take
      their lives, but they must act independently. This legal situation has given rise
      to a do-it-yourself ("DIY") right-to-die movement dedicated to technologies and
      information to enhance the possibilities for planned and humane suicide, while
      limiting the legal exposure of sympathetic third parties (Martin, 2010; Ogden
      2001). My aim is to summarize the legal history of suicide in Canada and discuss 
      the emerging social movement for DIY suicide and assistance in suicide. Exit
      International ("Exit"), based in Australia, is a leading organization in this
      movement. I present a case report that describes how a Canadian woman ended her
      life using DIY techniques learned from Exit. Some ethical and legal implications 
      for researching DIY suicide are discussed. I argue that the DIY movement is an
      undesirable consequence of prohibition.
FAU - Ogden, Russel D
AU  - Ogden RD
AD  - Department of Criminology, Kwantlen Polytechnic University, British Columbia.
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Health Law Can
JT  - Health law in Canada
JID - 8101300
MH  - Canada
MH  - Ethics, Research
MH  - Female
MH  - Homicide
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Right to Die/*legislation & jurisprudence
MH  - Suicide, Assisted/*legislation & jurisprudence
EDAT- 2011/01/11 06:00
MHDA- 2011/02/17 06:00
CRDT- 2011/01/11 06:00
PHST- 2011/01/11 06:00 [entrez]
PHST- 2011/01/11 06:00 [pubmed]
PHST- 2011/02/17 06:00 [medline]
PST - ppublish
SO  - Health Law Can. 2010 Nov;31(2):37-52.


PMID- 21213472
OWN - NLM
STAT- MEDLINE
DCOM- 20110210
LR  - 20110106
IS  - 0927-3042 (Print)
IS  - 0927-3042 (Linking)
VI  - 156
DP  - 2010
TI  - Oncofertility: ethical, legal, social, and medical perspectives. Preface.
PG  - v-vii
FAU - Woodruff, Teresa K
AU  - Woodruff TK
AD  - Feinberg School of Medicine, Northwestern University, Chicago, Il, USA.
      tkw@northwestern.edu
FAU - Zoloth, Laurie
AU  - Zoloth L
FAU - Campo-Engelstein, Lisa
AU  - Campo-Engelstein L
FAU - Rodriguez, Sarah
AU  - Rodriguez S
LA  - eng
PT  - Introductory Journal Article
PL  - United States
TA  - Cancer Treat Res
JT  - Cancer treatment and research
JID - 8008541
SB  - IM
MH  - *Ethics, Medical
MH  - Female
MH  - Humans
MH  - Infertility/*prevention & control
MH  - *Legislation, Medical
MH  - Male
MH  - Neoplasms/*complications/therapy
MH  - *Social Responsibility
EDAT- 2011/01/11 06:00
MHDA- 2011/02/11 06:00
CRDT- 2011/01/11 06:00
PHST- 2011/01/11 06:00 [entrez]
PHST- 2011/01/11 06:00 [pubmed]
PHST- 2011/02/11 06:00 [medline]
PST - ppublish
SO  - Cancer Treat Res. 2010;156:v-vii.


PMID- 21212582
OWN - NLM
STAT- MEDLINE
DCOM- 20110513
LR  - 20191111
IS  - 1349-7413 (Electronic)
IS  - 0911-4300 (Linking)
VI  - 33
IP  - 6
DP  - 2010
TI  - ["Creation of mouse models for human diseases"].
PG  - 304-11
AB  - To translate research findings into medicine and drug development, we have been
      performing in vivo research using primary human samples. Development of mouse
      models with reconstituted human immunity would be critical to overcome technical 
      and ethical constraints associated with in vivo human research. To this end, we
      have created humanized mice by intravenously injecting purified human
      hematopoietic stem cells (HSCs) into immune-compromised NOD/SCID/IL2rgKO
      newborns. This xenogeneic transplantation system allows long-term engraftment and
      multi-lineage differentiation of human HSCs. The humanized mouse fully
      reconstituted with human myeloid and lymphoid subsets is expected to serve as an 
      in vivo platform for the investigation of human immune function. In addition to
      understanding normal human hematopoiesis and immunity, the use of humanized mice 
      is expected to allow investigators to translate their research findings into
      therapeutic and pharmaceutical development. As a possibility for such
      translation, we developed an in vivo model of human acute myeloid leukemia (AML),
      a disease in which the majority of patients succumb to relapse. Using the model, 
      we examined the pathogenesis of AML and tried to clarify the role of AML stem
      cells in chemotherapy resistance and relapse. Humanized mouse model for both
      normal and diseased immuno-hematopoietic system is opening a new era in
      translational medicine.
FAU - Ishikawa, Fumihiko
AU  - Ishikawa F
AD  - RIKEN Research Center for Allergy & Immunology Research Unit for Human Disease
      Models.
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Nihon Rinsho Meneki Gakkai Kaishi
JT  - Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology
JID - 9505992
SB  - IM
MH  - Animals
MH  - *Disease Models, Animal
MH  - *Hematopoietic Stem Cells
MH  - Humans
MH  - Leukemia, Myeloid, Acute
MH  - Mice
EDAT- 2011/01/08 06:00
MHDA- 2011/05/14 06:00
CRDT- 2011/01/08 06:00
PHST- 2011/01/08 06:00 [entrez]
PHST- 2011/01/08 06:00 [pubmed]
PHST- 2011/05/14 06:00 [medline]
AID - JST.JSTAGE/jsci/33.304 [pii]
AID - 10.2177/jsci.33.304 [doi]
PST - ppublish
SO  - Nihon Rinsho Meneki Gakkai Kaishi. 2010;33(6):304-11. doi: 10.2177/jsci.33.304.


PMID- 21211229
OWN - NLM
STAT- MEDLINE
DCOM- 20111128
LR  - 20211203
IS  - 0412-4081 (Print)
IS  - 0412-4081 (Linking)
VI  - 46
IP  - 12
DP  - 2010 Dec
TI  - [Present status on studies of differentiation into retinal neurons and pigmented 
      cell from induced pluripotent stem cells].
PG  - 1139-42
AB  - Somatic cells could be induced into pluripotent stem (iPS) cells through
      transferring special genes (Oct4, Sox2, c-myc and Klf4). This has brought a
      revolutionary change in stem cell study and application. The generation of iPS
      cells has great potential and enormous significance as it can resolve some
      insurmountable problems in stem cells research, such as ethical dilemma, immune
      rejection, etc. Because of these characteristics, it plays an important role in
      the repair of various tissues and organs. Rapid progress in this field during the
      past 3 years convinced us that iPS cells will be more and more applicable in
      tissue engineering. The present paper reviews the progress of pre-clinical study 
      on iPS cells in the treatment of retinal and optic nerve diseases.
FAU - Meng, Feng-xi
AU  - Meng FX
AD  - Eye & ENT Hospital, Fudan University, Shanghai 200031, China.
FAU - Guo, Wen-yi
AU  - Guo WY
LA  - chi
PT  - Journal Article
PT  - Review
PL  - China
TA  - Zhonghua Yan Ke Za Zhi
JT  - [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
JID - 16210540R
SB  - IM
MH  - Cell Culture Techniques
MH  - *Cell Differentiation
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*cytology
MH  - Kruppel-Like Factor 4
MH  - Pigment Epithelium of Eye/*cytology
MH  - Retinal Neurons/*cytology
EDAT- 2011/01/08 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/01/08 06:00
PHST- 2011/01/08 06:00 [entrez]
PHST- 2011/01/08 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PST - ppublish
SO  - Zhonghua Yan Ke Za Zhi. 2010 Dec;46(12):1139-42.


PMID- 21210914
OWN - NLM
STAT- MEDLINE
DCOM- 20110503
LR  - 20110504
IS  - 1442-2018 (Electronic)
IS  - 1441-0745 (Linking)
VI  - 12
IP  - 4
DP  - 2010 Dec
TI  - Discovering the value of research supervision.
PG  - 400-1
LID - 10.1111/j.1442-2018.2010.00565.x [doi]
AB  - The aim of this editorial was to discover the value of research supervision by
      reflecting on many years of researching the phenomenon. The main benefits of
      research supervision are improvements in the quality of academic education, the
      quality of practice, and nursing and midwifery disciplines. Hence, these values
      must be acknowledged and more resources, both at universities and in clinical
      practice, are required. The advantages of research supervision are inherent in
      all its aspects. More education in research supervision is required in order to
      implement strategies that improve the level of quality in practice, as well as
      further research in this area. From an ethical perspective, one of the research
      questions that needs to be addressed is: Which different responsibilities and
      rights are important in the supervisory process? This question can be answered by
      using a multidisciplinary perspective for the purpose of enhancing the quality of
      education and patient care.
CI  - (c) 2011 Blackwell Publishing Asia Pty Ltd.
FAU - Severinsson, Elisabeth
AU  - Severinsson E
AD  - Centre for Women's, Family & Child Health, Vestfold University College, Tonsberg,
      Norway. elisabeth.severinsson@hive.no
LA  - eng
PT  - Editorial
PL  - Australia
TA  - Nurs Health Sci
JT  - Nursing & health sciences
JID - 100891857
SB  - IM
CIN - Nurs Health Sci. 2011 Mar;13(1):9. PMID: 21392195
MH  - Humans
MH  - Models, Nursing
MH  - Nurse's Role
MH  - *Nursing Research/education/ethics/organization & administration
MH  - Nursing, Supervisory/*organization & administration
MH  - Patient Care Team/organization & administration
MH  - Preceptorship/organization & administration
EDAT- 2011/01/08 06:00
MHDA- 2011/05/04 06:00
CRDT- 2011/01/08 06:00
PHST- 2011/01/08 06:00 [entrez]
PHST- 2011/01/08 06:00 [pubmed]
PHST- 2011/05/04 06:00 [medline]
AID - 10.1111/j.1442-2018.2010.00565.x [doi]
PST - ppublish
SO  - Nurs Health Sci. 2010 Dec;12(4):400-1. doi: 10.1111/j.1442-2018.2010.00565.x.


PMID- 21210553
STAT- Publisher
DA  - 20110107
ISBN- 9780309157063
ISBN- 0309157064
PB  - National Academies Press (US)
CTI - The National Academies Collection: Reports funded by National Institutes of
      Health
DP  - 2010
BTI - Conducting Biosocial Surveys: Collecting, Storing, Accessing, and Protecting
      Biospecimens and Biodata
AB  - Recent years have seen a growing tendency for social scientists to collect
      biological specimens, such as blood, urine, and saliva as part of large-scale
      household surveys. By combining biological and social data, scientists are
      opening up new fields of inquiry and are able for the first time to address many 
      new questions and connections. But including biospecimens in social surveys also 
      adds a great deal of complexity and cost to the investigator's task. Along with
      the usual concerns about informed consent, privacy issues, and the best ways to
      collect, store, and share data, researchers now face a variety of issues that are
      much less familiar or that appear in a new light. In particular, collecting and
      storing human biological materials for use in social science research raises
      additional legal, ethical, and social issues, as well as practical issues related
      to the storage, retrieval, and sharing of data. For example, acquiring biological
      data and linking them to social science databases requires a more complex
      informed consent process, the development of a biorepository, the establishment
      of data sharing policies, and the creation of a process for deciding how the data
      are going to be shared and used for secondary analysis-all of which add cost to a
      survey and require additional time and attention from the investigators. These
      issues also are likely to be unfamiliar to social scientists who have not worked 
      with biological specimens in the past. Adding to the attraction of collecting
      biospecimens but also to the complexity of sharing and protecting the data is the
      fact that this is an era of incredibly rapid gains in our understanding of
      complex biological and physiological phenomena. Thus the trade-offs between the
      risks and opportunities of expanding access to research data are constantly
      changing. This report, which was funded by the National Institute on Aging (NIA),
      offers findings and recommendations concerning the best approaches to the
      collection, storage, use, and sharing of biospecimens gathered in social science 
      surveys and the digital representations of biological data derived therefrom. It 
      is aimed at researchers interested in carrying out such surveys, their
      institutions, and their funding agencies.
CI  - Copyright (c) 2010, National Academy of Sciences.
CN  - National Research Council (US) Panel on Collecting, Storing, Accessing, and
      Protecting Biological Specimens and Biodata in Social Surveys
FED - Hauser, Robert M
ED  - Hauser RM
FED - Weinstein, Maxine
ED  - Weinstein M
FED - Pool, Robert
ED  - Pool R
FED - Cohen, Barney
ED  - Cohen B
LA  - eng
GR  - N01 OD042139/NIH HHS/United States
PT  - Review
PT  - Book
PL  - Washington (DC)
EDAT- 2011/01/07 06:00
MHDA- 2011/01/07 06:00
CDAT- 2011/01/07 06:00
AID - NBK50732 [bookaccession]
AID - 10.17226/12942 [doi]


PMID- 21210338
OWN - NLM
STAT- MEDLINE
DCOM- 20110525
LR  - 20181201
IS  - 1439-1899 (Electronic)
IS  - 0174-304X (Linking)
VI  - 41
IP  - 5
DP  - 2010 Oct
TI  - Zolpidem for persistent vegetative state--a placebo-controlled trial in
      pediatrics.
PG  - 223-7
LID - 10.1055/s-0030-1269893 [doi]
AB  - OBJECTIVE: The aim of this study was to determine if zolpidem is associated with 
      improved responsiveness or regional cerebral perfusion in patients with
      persistent vegetative states. METHODS: Following ethics approval, children with
      persistent vegetative state were enrolled in a prospective, double-blind,
      placebo-controlled randomised trial. Patients underwent 2 treatments of 4 days,
      separated by 10 days. Each child received either a daily dose of zolpidem or
      placebo with a dosage of 0.14-0.2 mg/kg. Responsiveness and regional cerebral
      perfusion were the outcomes of interest. These were assessed using the Rancho
      levels of cognitive functioning scale, the coma/near-coma scale and F (18)-FDG
      positron emission tomography. These were conducted at baseline and after
      completion of the treatments. RESULTS: 3 children were enrolled. The Rancho
      assessment scales showed no change with treatment. The coma/near-coma scale
      showed a tendency to increase with zolpidem, suggesting reduced responsiveness - 
      when compared to baseline or placebo. The positron emission tomography scans
      showed no significant changes between treatments. CONCLUSION: Zolpidem was
      associated with a tendency towards reduced responsiveness in patients with
      persistent vegetative states. There were no objective changes on positron
      emission tomography suggestive of an associated increase in cerebral blood flow
      with zolpidem. It would appear that zolpidem does not offer a beneficial effect
      in this setting.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Snyman, N
AU  - Snyman N
AD  - Rehabilitation Department, The Children's Hospital at Westmead, Westmead, Sydney,
      Australia.
FAU - Egan, J R
AU  - Egan JR
FAU - London, K
AU  - London K
FAU - Howman-Giles, R
AU  - Howman-Giles R
FAU - Gill, D
AU  - Gill D
FAU - Gillis, J
AU  - Gillis J
FAU - Scheinberg, A
AU  - Scheinberg A
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110105
PL  - Germany
TA  - Neuropediatrics
JT  - Neuropediatrics
JID - 8101187
RN  - 0 (GABA-A Receptor Antagonists)
RN  - 0 (Pyridines)
RN  - 7K383OQI23 (Zolpidem)
SB  - IM
MH  - Adolescent
MH  - Brain/*diagnostic imaging
MH  - Cerebrovascular Circulation/*drug effects
MH  - Child
MH  - Child, Preschool
MH  - Double-Blind Method
MH  - GABA-A Receptor Antagonists/*therapeutic use
MH  - Humans
MH  - Male
MH  - Persistent Vegetative State/diagnostic imaging/*drug therapy
MH  - Prospective Studies
MH  - Pyridines/*therapeutic use
MH  - Radionuclide Imaging
MH  - Treatment Outcome
MH  - Zolpidem
EDAT- 2011/01/07 06:00
MHDA- 2011/05/26 06:00
CRDT- 2011/01/07 06:00
PHST- 2011/01/07 06:00 [entrez]
PHST- 2011/01/07 06:00 [pubmed]
PHST- 2011/05/26 06:00 [medline]
AID - 10.1055/s-0030-1269893 [doi]
PST - ppublish
SO  - Neuropediatrics. 2010 Oct;41(5):223-7. doi: 10.1055/s-0030-1269893. Epub 2011 Jan
      5.


PMID- 21210184
OWN - NLM
STAT- MEDLINE
DCOM- 20110613
LR  - 20211020
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 22
IP  - 4
DP  - 2010 Dec
TI  - The pre-conditions for "building capacity" in an ethics program.
PG  - 287-97
LID - 10.1007/s10730-010-9147-0 [doi]
AB  - Most organizations and/or their sub-units like ethics programs want to acquire
      the knowledge, skills and other resources needed to achieve their goals
      efficiently and effectively. Thus, they want to acquire or develop needed
      "capacity." But there are pre-conditions to building capacity that are often
      overlooked or forgotten, but which nevertheless, must be in place before capacity
      can be developed. This essay identifies these pre-conditions and discusses why
      they are necessary before attempts are made to enhance the capacity of any ethics
      program. The essay closes by offering a series of questions that ethics program
      leaders/and or members can asked themselves to assess whether or not these
      pre-conditions exist.
FAU - Mills, Ann E
AU  - Mills AE
AD  - Program in Ethics and Policy, Center for Biomedical Ethics, University of
      Virginia, Box 800858, Charlottesville, VA 22908, USA. Amh2r@virginia.edu
FAU - Rorty, Mary V
AU  - Rorty MV
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - *Capacity Building
MH  - Ethics Consultation/*organization & administration
MH  - Health Facilities
MH  - Organizational Culture
MH  - United States
EDAT- 2011/01/07 06:00
MHDA- 2011/06/15 06:00
CRDT- 2011/01/07 06:00
PHST- 2011/01/07 06:00 [entrez]
PHST- 2011/01/07 06:00 [pubmed]
PHST- 2011/06/15 06:00 [medline]
AID - 10.1007/s10730-010-9147-0 [doi]
PST - ppublish
SO  - HEC Forum. 2010 Dec;22(4):287-97. doi: 10.1007/s10730-010-9147-0.


PMID- 21208703
OWN - NLM
STAT- MEDLINE
DCOM- 20111212
LR  - 20180304
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 73
IP  - 4
DP  - 2011 Aug
TI  - Theorising the 'human subject' in biomedical research: international clinical
      trials and bioethics discourses in contemporary Sri Lanka.
PG  - 515-521
LID - S0277-9536(10)00818-X [pii]
LID - 10.1016/j.socscimed.2010.11.024 [doi]
AB  - The global spread of clinical trials activity is accompanied by a parallel growth
      in research governance and human subject protection. In this paper we analyse how
      dominant ideas of the 'human subject' in clinical trials are played out in
      countries that are deemed to be scientifically under-developed. Specifically, we 
      show how rhetorics of individualism, rationality and autonomy implicit in
      international ethical guidelines governing human subject research are
      operationalised and localised. We give insights into the ways in which new
      knowledge forms become embedded in practice. Using the recent upsurge in clinical
      trials in Sri Lanka as a case study, based on interviews with 23 doctors and
      researchers carried out during ethnographic fieldwork between 2008-2009, this
      article explores the tensions that arise for doctors involved with the promotion 
      of bioethics and the attempts to bring local research governance up to
      international standards. The doctors and researchers intercept, interpret and
      critique the notions of human subject implicit in new forms of research
      governance. From their accounts we have identified two concerns. The first is a
      critique of dominant ideas of the 'human subject' that is informed by ideas of
      patiency rooted in paternalistic notions of the doctor-patient relationship.
      Second, 'human subjects' are seen as gendered, and located within family
      relationships. Both of these bring into question the research subjects' ability
      to give informed consent and compromise the ideal of an autonomous subject.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Sariola, Salla
AU  - Sariola S
AD  - University of Durham, Durham, UK. Electronic address: salla.sariola@durham.ac.uk.
FAU - Simpson, Bob
AU  - Simpson B
AD  - University of Durham, Durham, UK.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101209
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Clinical Trials as Topic/*ethics
MH  - Humans
MH  - Informed Consent/*ethics
MH  - *Internationality
MH  - Paternalism/ethics
MH  - Physician-Patient Relations
MH  - Qualitative Research
MH  - *Research Subjects
MH  - Sri Lanka
EDAT- 2011/01/07 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/01/07 06:00
PHST- 2010/05/25 00:00 [received]
PHST- 2010/11/15 00:00 [revised]
PHST- 2010/11/15 00:00 [accepted]
PHST- 2011/01/07 06:00 [entrez]
PHST- 2011/01/07 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - S0277-9536(10)00818-X [pii]
AID - 10.1016/j.socscimed.2010.11.024 [doi]
PST - ppublish
SO  - Soc Sci Med. 2011 Aug;73(4):515-521. doi: 10.1016/j.socscimed.2010.11.024. Epub
      2010 Dec 9.


PMID- 21208061
OWN - NLM
STAT- MEDLINE
DCOM- 20110422
LR  - 20110113
IS  - 1557-8577 (Electronic)
IS  - 1549-1684 (Linking)
VI  - 13
IP  - 6
DP  - 2010 Dec
TI  - An ethical assessment of postmenopausal motherhood against the backdrop of
      successful antiaging medicine.
PG  - 741-7
LID - 10.1089/rej.2009.1012 [doi]
AB  - By creating fertility reserves, women are now able to become pregnant using their
      own eggs, even after menopause. Multiple arguments already exist against
      postmenopausal motherhood, most of which stress the potential risk of damage
      involved due to the mother's advanced age. Consequently, the question arises: Can
      successful antiaging medicine be applied to preserve or enhance cognitive and
      physical capacity at an advanced age and invalidate these objections? In this
      article, we shall explore this issue further and come to three main conclusions: 
      (1) Until now, enabling postmenopausal women to become pregnant has not been a
      specific objective of antiaging medicine. (2) Postmenopausal motherhood can find 
      legitimacy through the development and success of antiaging medicine. (3) The
      acceptance of postmenopausal motherhoods in our society first requires that
      antiaging medicine itself find some sort of ethical legitimacy. To evaluate the
      arguments for and against antiaging medicine and postmenopausal motherhood, it is
      important to take into consideration two points more in depth, which are
      constantly being impacted by both medical arguments alike: (1) The identity and
      role of medicine itself as well as (2) the normative role of our body`s natural
      boundaries.
FAU - Bittner, Uta
AU  - Bittner U
AD  - Department of Medical Ethics and History of Medicine, University of Freiburg,
      Freiburg, Germany. bittner@egm.uni-freiburg.de
FAU - Eichinger, Tobias
AU  - Eichinger T
LA  - eng
PT  - Journal Article
DEP - 20110105
PL  - United States
TA  - Rejuvenation Res
JT  - Rejuvenation research
JID - 101213381
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Aging/*physiology
MH  - *Ethics, Medical
MH  - Female
MH  - Fertility
MH  - Humans
MH  - Infertility, Female
MH  - *Maternal Age
MH  - *Mothers
MH  - *Pharmaceutical Preparations
MH  - Postmenopause/*physiology
MH  - Pregnancy
MH  - *Rejuvenation
EDAT- 2011/01/07 06:00
MHDA- 2011/04/26 06:00
CRDT- 2011/01/07 06:00
PHST- 2011/01/07 06:00 [entrez]
PHST- 2011/01/07 06:00 [pubmed]
PHST- 2011/04/26 06:00 [medline]
AID - 10.1089/rej.2009.1012 [doi]
PST - ppublish
SO  - Rejuvenation Res. 2010 Dec;13(6):741-7. doi: 10.1089/rej.2009.1012. Epub 2011 Jan
      5.


PMID- 21207825
OWN - NLM
STAT- MEDLINE
DCOM- 20110121
LR  - 20161125
IS  - 0029-6570 (Print)
IS  - 0029-6570 (Linking)
VI  - 25
IP  - 13
DP  - 2010 Dec 1-7
TI  - Male nurses and the protection of female patient dignity.
PG  - 42-9
AB  - Nurses need to be aware of their professional, legal and ethical responsibilities
      towards patients. Male nurses in particular face problems in their practice as a 
      result of their gender and the stereotypes associated with male nurses. Such
      stereotypes can act as a barrier to their duty of care. This article examines the
      challenges associated with male nurses carrying out intimate, physical care. It
      discusses the ethical, legal and professional issues that male nurses should
      consider in relation to maintenance of patient dignity during nursing care
      provision, particularly in relation to female patients.
FAU - Prideaux, Antony
AU  - Prideaux A
AD  - Tewkesbury Community Hospital, Gloucester. antony.prideaux@glos.nhs.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Stand
JT  - Nursing standard (Royal College of Nursing (Great Britain) : 1987)
JID - 9012906
MH  - Female
MH  - Humans
MH  - Male
MH  - Malpractice/legislation & jurisprudence
MH  - Nurse's Role/psychology
MH  - *Nurse-Patient Relations/ethics
MH  - *Nurses, Male/ethics/organization & administration/psychology
MH  - *Patient Rights/ethics/legislation & jurisprudence
MH  - Principle-Based Ethics
MH  - Privacy/legislation & jurisprudence/psychology
MH  - Professional Misconduct/ethics/legislation & jurisprudence/psychology
MH  - Sex Factors
MH  - Social Values
MH  - State Medicine/ethics/organization & administration
MH  - Stereotyping
MH  - United Kingdom
EDAT- 2011/01/07 06:00
MHDA- 2011/01/22 06:00
CRDT- 2011/01/07 06:00
PHST- 2011/01/07 06:00 [entrez]
PHST- 2011/01/07 06:00 [pubmed]
PHST- 2011/01/22 06:00 [medline]
AID - 10.7748/ns2010.12.25.13.42.c8121 [doi]
PST - ppublish
SO  - Nurs Stand. 2010 Dec 1-7;25(13):42-9. doi: 10.7748/ns2010.12.25.13.42.c8121.


PMID- 21207725
OWN - NLM
STAT- MEDLINE
DCOM- 20110301
LR  - 20110104
IS  - 1660-9379 (Print)
IS  - 1660-9379 (Linking)
VI  - 6
IP  - 273
DP  - 2010 Dec 1
TI  - [Hunger strike and forced feeding: a historical look at medical practices].
PG  - 2313-8
AB  - Hunger strike is not a disease but a common situation in prisons. This article
      takes a historical look at medical practices in connection with the forced
      feeding of hunger strikers. We now know the fate of the strikers who were
      subjected to forced feeding. Depending on the context and the political situation
      in the country, the fate of these people, mostly political prisoners, is
      described as humiliating and abominable frequently ending in death or irreparable
      consequences. Particularly difficult for health professionals, this act raises
      clinical, ethical and legal questions and refers to the fundamental principles of
      medicine.
FAU - Rieder, Jean-Pierre
AU  - Rieder JP
AD  - Departement de medecine communautaire, de premier recours et des urgences, HUG,
      Geneve. Jean-Pierre.Rieder@hcuge.ch
FAU - Huber-Giseke, Tina
AU  - Huber-Giseke T
FAU - Getaz, Laurent
AU  - Getaz L
FAU - Kramer-Gauchat, Marie-Claire
AU  - Kramer-Gauchat MC
FAU - Nyffenegger, Laurent
AU  - Nyffenegger L
FAU - Gaspoz, Jean-Michel
AU  - Gaspoz JM
FAU - Wolff, Hans
AU  - Wolff H
LA  - fre
PT  - English Abstract
PT  - Historical Article
PT  - Journal Article
TT  - Jeune de protestation et alumentation forcee: releve de pratiques historiques.
PL  - Switzerland
TA  - Rev Med Suisse
JT  - Revue medicale suisse
JID - 101219148
SB  - IM
MH  - Enteral Nutrition/*history/methods
MH  - Ethics, Medical
MH  - Female
MH  - History, 20th Century
MH  - Humans
MH  - *Hunger
MH  - Male
MH  - Politics
MH  - *Prisoners
MH  - *Strikes, Employee
MH  - Torture
MH  - Women's Rights
EDAT- 2011/01/07 06:00
MHDA- 2011/03/02 06:00
CRDT- 2011/01/07 06:00
PHST- 2011/01/07 06:00 [entrez]
PHST- 2011/01/07 06:00 [pubmed]
PHST- 2011/03/02 06:00 [medline]
PST - ppublish
SO  - Rev Med Suisse. 2010 Dec 1;6(273):2313-8.


PMID- 21207106
OWN - NLM
STAT- MEDLINE
DCOM- 20120124
LR  - 20211020
IS  - 1612-9210 (Electronic)
IS  - 1612-9202 (Linking)
VI  - 7
IP  - 4
DP  - 2010 Dec
TI  - A reflective lens: applying critical systems thinking and visual methods to
      ecohealth research.
PG  - 414-24
LID - 10.1007/s10393-010-0362-6 [doi]
AB  - Critical systems methodology has been advocated as an effective and ethical way
      to engage with the uncertainty and conflicting values common to ecohealth
      problems. We use two contrasting case studies, coral reef management in the
      Philippines and national park management in Australia, to illustrate the value of
      critical systems approaches in exploring how people respond to environmental
      threats to their physical and spiritual well-being. In both cases, we used visual
      methods--participatory modeling and rich picturing, respectively. The critical
      systems methodology, with its emphasis on reflection, guided an appraisal of the 
      research process. A discussion of these two case studies suggests that visual
      methods can be usefully applied within a critical systems framework to offer new 
      insights into ecohealth issues across a diverse range of socio-political
      contexts. With this article, we hope to open up a conversation with other
      practitioners to expand the use of visual methods in integrated research.
FAU - Cleland, Deborah
AU  - Cleland D
AD  - Fenner School of Environment and Society, ANU College of Medicine Biology and
      Environment, Australian National University, Canberra, ACT 0200, Australia.
FAU - Wyborn, Carina
AU  - Wyborn C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110105
PL  - United States
TA  - Ecohealth
JT  - EcoHealth
JID - 101222144
SB  - IM
MH  - *Art
MH  - Australia
MH  - Conservation of Natural Resources/*methods
MH  - Coral Reefs
MH  - Ecosystem
MH  - Education
MH  - Health Promotion
MH  - Health Services Research/*methods
MH  - Humans
MH  - Learning
MH  - Philippines
MH  - Photography/*instrumentation/methods
MH  - Public Health/education
MH  - *Systems Theory
MH  - Uncertainty
MH  - *Vision, Ocular
EDAT- 2011/01/06 06:00
MHDA- 2012/01/25 06:00
CRDT- 2011/01/06 06:00
PHST- 2010/01/08 00:00 [received]
PHST- 2010/11/15 00:00 [accepted]
PHST- 2010/10/31 00:00 [revised]
PHST- 2011/01/06 06:00 [entrez]
PHST- 2011/01/06 06:00 [pubmed]
PHST- 2012/01/25 06:00 [medline]
AID - 10.1007/s10393-010-0362-6 [doi]
PST - ppublish
SO  - Ecohealth. 2010 Dec;7(4):414-24. doi: 10.1007/s10393-010-0362-6. Epub 2011 Jan 5.


PMID- 21206629
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1998-3751 (Electronic)
IS  - 0253-7613 (Linking)
VI  - 42
IP  - 5
DP  - 2010 Oct
TI  - Atorvastatin-induced pancreatitis.
PG  - 324-5
LID - 10.4103/0253-7613.70400 [doi]
AB  - Drugs account for 1-2% of all cases of pancreatitis. A 58-year-old man was
      prescribed atorvastatin 10 mg for 6 months for hyperlipidemia. He developed acute
      abdominal pain and vomiting with epigastric tenderness. Serum lipase and CT scan 
      of the patient suggested the presence of acute pancreatitis. The patient was
      hospitalized; atorvastatin was stopped and treated symptomatically. He recovered 
      completely within 10 days of drug withdrawal. The causality of the adverse drug
      reaction according to Naranjo and WHO-UMC Scale was probable. The exact mechanism
      of pancreatitis due to atorvastatin is not known. It may be a class effect of HMG
      CoA reductase inhibitors as it had been reported with other statins too. The
      definite causal relationship is difficult to establish, as rechallenge with the
      suspected drug was not done due to ethical consideration.
FAU - Prajapati, Samir
AU  - Prajapati S
AD  - Department of Pharmacology, B. J. Medical College, Ahmedabad, India.
FAU - Shah, Samidh
AU  - Shah S
FAU - Desai, Chetna
AU  - Desai C
FAU - Desai, Mira
AU  - Desai M
FAU - Dikshit, R K
AU  - Dikshit RK
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Pharmacol
JT  - Indian journal of pharmacology
JID - 7902477
PMC - PMC2959220
OTO - NOTNLM
OT  - Adverse drug reaction
OT  - atorvastatin
OT  - pancreatitis
EDAT- 2011/01/06 06:00
MHDA- 2011/01/06 06:01
CRDT- 2011/01/06 06:00
PHST- 2010/05/05 00:00 [received]
PHST- 2010/07/08 00:00 [revised]
PHST- 2010/07/13 00:00 [revised]
PHST- 2011/01/06 06:00 [entrez]
PHST- 2011/01/06 06:00 [pubmed]
PHST- 2011/01/06 06:01 [medline]
AID - 10.4103/0253-7613.70400 [doi]
PST - ppublish
SO  - Indian J Pharmacol. 2010 Oct;42(5):324-5. doi: 10.4103/0253-7613.70400.


PMID- 21206615
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20220409
IS  - 1998-3751 (Electronic)
IS  - 0253-7613 (Linking)
VI  - 42
IP  - 5
DP  - 2010 Oct
TI  - Evaluation of rationality of promotional drug literature using World Health
      Organization guidelines.
PG  - 267-72
LID - 10.4103/0253-7613.70020 [doi]
AB  - OBJECTIVES: The study was aimed to evaluate collected drug promotional brochures 
      for accuracy, consistency, and validity of the information presented in it, using
      World Health Organization (WHO) criteria for ethical medicinal drug promotion.
      Drug promotional brochures were evaluated for the type of claims and pictorial
      content presented in it and for references cited in support of these claims.
      MATERIAL AND METHODS: This observational, cross-sectional study was conducted in 
      the outpatient department of Government Medical College and Hospital, Nagpur,
      India. In addition to the fulfillment of "WHO criteria, 1988," we examined 513
      promotional brochures for the type of claims and pictorial content presented in
      it and references quoted in support of claims to check their retrievability,
      type, and authenticity. RESULTS: None of the promotional literature fulfilled all
      WHO criteria. Majority (92%) brochures claimed about the efficacy of product, and
      a few about safety (37.8%). Out of 1003 references given in support of various
      claims, 84.4% were from journals and only 28.5% were validly presented
      researches. Brochures presenting irrelevant pictures were 41.3%, whereas brief
      prescription information (BPI) of the promoted drug was given only by 8.8%
      brochures. CONCLUSION: Pharmaceutical industries did not follow the WHO
      guidelines while promoting their products, thus aiming to satisfying their
      commercial motive rather than fulfill the educational aspect of promotion.
FAU - Mali, Smita N
AU  - Mali SN
AD  - Department of Pharmacology, LTMC, Sion, Mumbai, India.
FAU - Dudhgaonkar, Sujata
AU  - Dudhgaonkar S
FAU - Bachewar, N P
AU  - Bachewar NP
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Pharmacol
JT  - Indian journal of pharmacology
JID - 7902477
PMC - PMC2959206
OTO - NOTNLM
OT  - Brief prescription information
OT  - drug marketing
OT  - medicine promotion
OT  - promotional literature
EDAT- 2011/01/06 06:00
MHDA- 2011/01/06 06:01
CRDT- 2011/01/06 06:00
PHST- 2010/04/19 00:00 [received]
PHST- 2010/06/17 00:00 [revised]
PHST- 2010/07/20 00:00 [accepted]
PHST- 2011/01/06 06:00 [entrez]
PHST- 2011/01/06 06:00 [pubmed]
PHST- 2011/01/06 06:01 [medline]
AID - 10.4103/0253-7613.70020 [doi]
PST - ppublish
SO  - Indian J Pharmacol. 2010 Oct;42(5):267-72. doi: 10.4103/0253-7613.70020.


PMID- 21205543
OWN - NLM
STAT- MEDLINE
DCOM- 20110322
LR  - 20110105
IS  - 1022-386X (Print)
IS  - 1022-386X (Linking)
VI  - 20
IP  - 12
DP  - 2010 Dec
TI  - Mediterranean glucose-6-phosphate dehydrogenase (G6PD(C563T)) mutation among
      Jordanian females with acute hemolytic crisis.
PG  - 794-7
LID - 12.2010/JCPSP.794797 [doi]
AB  - OBJECTIVE: To evaluate the G6PD(C563T) Mediterranean mutation among Jordanian
      females who were admitted to Princess Rahma Teaching Hospital (PRTH) with/or
      previous history of favism. STUDY DESIGN: A descriptive study. PLACE AND DURATION
      OF STUDY: Jordanian University of Science and Technology and PRTH, from October
      2003 to October 2004. METHODOLOGY: After obtaining approval from the Ethics
      Committee of Jordanian University of Science and Technology, a total of 32
      females were included in this study. Samples from 15 healthy individual females
      were used as a negative control. Blood samples from these patients were collected
      and analyzed by allele-specific polymerase chain reaction (AS-PCR) to determine
      the G6PD(C563T) mutation. RESULTS: Twenty one out of 32 patients were found to be
      G6PD(C563T) Mediterranean mutation (65.6%) positive. Three out of 21 patients
      were homozygous and remaining 18 were heterozygous for G6PD(C563T) Mediterranean 
      mutation. Eleven (34.4%) out of 32 patients were found to be negative for
      G6PD(C563T) mutation indicating the presence of other G6PD mutations in the study
      sample. CONCLUSION: G6PD(C563T) Mediterranean mutation accounted for 65.6% of the
      study sample with favism in the North of Jordan. There is likely to be another
      G6PD deficiency variant implicated in acute hemolytic crisis (favism).
FAU - Al-Alimi, Abdullah Abdul Jabbar Ahmed
AU  - Al-Alimi AA
AD  - Department of Haematolgy, Advanced Medical and Dental Institute (AMDI),
      University Sains Malaysia, Malaysia.
FAU - Kanakiri, Naeem
AU  - Kanakiri N
FAU - Kamil, Muhammad
AU  - Kamil M
FAU - Al-Rimawi, Hala Saleh
AU  - Al-Rimawi HS
FAU - Zaki, Abdul Hamid
AU  - Zaki AH
FAU - Yusoff, Narazah Mohammad
AU  - Yusoff NM
LA  - eng
PT  - Journal Article
PL  - Pakistan
TA  - J Coll Physicians Surg Pak
JT  - Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
JID - 9606447
RN  - EC 1.1.1.49 (Glucosephosphate Dehydrogenase)
SB  - IM
MH  - Acute Disease
MH  - Favism/complications/*genetics
MH  - Female
MH  - Glucosephosphate Dehydrogenase/*genetics
MH  - Glucosephosphate Dehydrogenase Deficiency/complications/*genetics
MH  - Hemolysis/*genetics
MH  - Humans
MH  - Jordan
MH  - *Mutation
EDAT- 2011/01/06 06:00
MHDA- 2011/03/23 06:00
CRDT- 2011/01/06 06:00
PHST- 2010/08/31 00:00 [received]
PHST- 2010/10/25 00:00 [accepted]
PHST- 2011/01/06 06:00 [entrez]
PHST- 2011/01/06 06:00 [pubmed]
PHST- 2011/03/23 06:00 [medline]
AID - 040579197 [pii]
AID - 12.2010/JCPSP.794797 [doi]
PST - ppublish
SO  - J Coll Physicians Surg Pak. 2010 Dec;20(12):794-7. doi: 12.2010/JCPSP.794797.


PMID- 21205258
OWN - NLM
STAT- MEDLINE
DCOM- 20110511
LR  - 20181201
IS  - 1475-1313 (Electronic)
IS  - 0275-5408 (Linking)
VI  - 30
IP  - 6
DP  - 2010 Nov
TI  - A survey of UK practitioner attitudes to the fitting of rigid gas permeable
      lenses.
PG  - 731-9
LID - 10.1111/j.1475-1313.2010.00790.x [doi]
AB  - PURPOSE: Rigid gas permeable (GP) contact lenses may provide the safest option
      for lens wear, but prescribing rates are in decline. This study investigated the 
      effect of practitioner attitudes on GP lens prescribing. METHODS: A questionnaire
      was developed using a focus group and a pilot study. Questions addressed clinical
      time spent fitting GP lenses, specialist equipment requirements and perceived
      safety and comfort. With ethical approval, the questionnaire was sent to 1000
      randomly selected UK registered eye care practitioners (ECPs). RESULTS: In
      general, ECPs enjoy the challenge of fitting GPs, although fitting takes longer
      than soft lens fitting. There is a difference in attitude between longer
      qualified and more recently qualified ECPs. Longer qualified ECPs more frequently
      reported enjoyment of the fitting challenges, recommended GP lenses to patients
      and were less likely to believe that GP lenses were becoming obsolete. ECPs are
      in strong agreement on the ocular health advantages of fitting GPs. They do not
      feel specialist equipment is generally needed, although some reported a
      topographer to be advantageous. The large majority of ECPs do not have access to 
      the specialist equipment they perceive to be normally associated with GP fitting 
      (radiuscope, V-gauge). They believe that initial fitting discomfort of GP fitting
      is a major drawback to their fitting, and while they feel this greatly improves
      with adaptation, they do not feel it reaches soft lens wear comfort. A total of
      30.3% of ECPs feel it is clinically acceptable to use topical anaesthetic during 
      GP fitting, but only 1.4% of ECPs regularly do so. CONCLUSIONS: ECPs are aware of
      the benefits that GP lenses provide in terms of ocular health. They find GPs take
      longer to fit, but they enjoyed the challenge of fitting, which suggests that
      they are not lacking in clinical skill, nor any specialist equipment. However,
      they are unhappy with initial patient comfort, and are not yet prepared to use
      topical anaesthetics during initial fitting. As a consequence, ECPs believe that 
      GP lenses are becoming obsolete. Negative practitioner attitudes toward various
      aspects of GP fitting may mean fewer recommendations to patients and reduced GP
      prescribing.
CI  - (c) 2010 The Authors. Ophthalmic and Physiological Optics (c) 2010 The College of
      Optometrists.
FAU - Gill, Felicity R
AU  - Gill FR
AD  - Cardiff University, School of Optometry and Vision Sciences, Contact Lens and
      Anterior Eye Research, Cardiff, UK.
FAU - Murphy, Paul J
AU  - Murphy PJ
FAU - Purslow, Christine
AU  - Purslow C
LA  - eng
PT  - Journal Article
PL  - England
TA  - Ophthalmic Physiol Opt
JT  - Ophthalmic & physiological optics : the journal of the British College of
      Ophthalmic Opticians (Optometrists)
JID - 8208839
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Clinical Competence
MH  - Contact Lenses/*psychology/statistics & numerical data/trends
MH  - Health Care Surveys
MH  - Humans
MH  - Optometry/instrumentation/statistics & numerical data/trends
MH  - Professional Practice/statistics & numerical data/trends
MH  - Prosthesis Fitting/instrumentation/psychology/statistics & numerical data
MH  - United Kingdom
EDAT- 2011/01/06 06:00
MHDA- 2011/05/12 06:00
CRDT- 2011/01/06 06:00
PHST- 2011/01/06 06:00 [entrez]
PHST- 2011/01/06 06:00 [pubmed]
PHST- 2011/05/12 06:00 [medline]
AID - 10.1111/j.1475-1313.2010.00790.x [doi]
PST - ppublish
SO  - Ophthalmic Physiol Opt. 2010 Nov;30(6):731-9. doi:
      10.1111/j.1475-1313.2010.00790.x.


PMID- 21204630
OWN - NLM
STAT- MEDLINE
DCOM- 20110502
LR  - 20181201
IS  - 1943-2755 (Electronic)
IS  - 0899-9546 (Linking)
VI  - 22
IP  - 6
DP  - 2010 Dec
TI  - Role of Service Providers of Needle Syringe Program in Preventing HIV/AIDS.
PG  - 546-57
LID - 10.1521/aeap.2010.22.6.546 [doi]
AB  - To provide a national-scale picture of the needle exchange program in Taiwan,
      this study examined (a) needle and syringe program (NSP) service providers'
      AIDS-relevant harm reduction knowledge and attitudes; and (b) NSP services
      schemes and operation barriers encountered by different service modalities. A
      self-administrated questionnaire was mailed to all participating NSP service
      providers in Taiwan. A total of 414 service providers completed the postal
      survey. This study confirms that NSP service providers play an essential role in 
      providing comprehensive activities to reduce HIV/AIDS infection for drug
      misusers. Knowledge and attitudes of service providers were found to be
      independently and important predictors of NSP service provisions. Community-based
      and clinical-based providers had diverse service schemes and encountered
      operation problems due to different organization characteristics, professional
      training, and ethical concern. For the future planning of NSP programs,
      service-specific education and professional support are essential component of
      service delivery and quality.
FAU - Tsai, Tzu-I
AU  - Tsai TI
AD  - School of Nursing, National Yang Ming University, Taipei, Taiwan.
FAU - Morisky, Donald E
AU  - Morisky DE
FAU - Chen, Yi-Ming A
AU  - Chen YM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - AIDS Educ Prev
JT  - AIDS education and prevention : official publication of the International Society
      for AIDS Education
JID - 9002873
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Female
MH  - HIV Infections/etiology/*prevention & control/transmission
MH  - Harm Reduction
MH  - Health Care Surveys
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Middle Aged
MH  - *Needle-Exchange Programs
MH  - Substance Abuse, Intravenous/*virology
MH  - Taiwan
MH  - Workforce
EDAT- 2011/01/06 06:00
MHDA- 2011/05/03 06:00
CRDT- 2011/01/06 06:00
PHST- 2011/01/06 06:00 [entrez]
PHST- 2011/01/06 06:00 [pubmed]
PHST- 2011/05/03 06:00 [medline]
AID - 10.1521/aeap.2010.22.6.546 [doi]
AID - 10.1521/aeap.2010.22.6.546 [pii]
PST - ppublish
SO  - AIDS Educ Prev. 2010 Dec;22(6):546-57. doi: 10.1521/aeap.2010.22.6.546.


PMID- 21199059
OWN - NLM
STAT- MEDLINE
DCOM- 20150617
LR  - 20141007
IS  - 1440-1754 (Electronic)
IS  - 1034-4810 (Linking)
VI  - 50
IP  - 10
DP  - 2014 Oct
TI  - Intrapleural urokinase versus surgical management of childhood empyema.
PG  - 823-6
LID - 10.1111/j.1440-1754.2010.01931.x [doi]
AB  - AIM: Empyema can be managed conservatively with intravenous antibiotics or
      invasively with a drain inserted under image guidance or via surgical evacuation.
      Both approaches are successful but comparisons of the method of drainage are few.
      This study compared clinical outcomes for empyema in previously well children
      from a single centre over a 12 year period. METHODS: A retrospective analysis of 
      cases over 12 years from the Children's Hospital at Westmead in Sydney was
      undertaken. Ethics committee approval was obtained. RESULTS: Seventy two cases
      were identified from medical records, 12 cases were excluded and 60 cases
      remained. The mean age was 4.7+/-4.3 years and there was a slight male
      preponderance. Treatment was divided into surgical management with a large bore
      drain alone [n=25] and minimally invasive management with the use of a "pigtail
      catheter" and intrapleural fibrinolytic ["Urkoinase"][n=35]. At presentation the 
      mean heart rate and respiratory rate were not statistically different. The median
      (range) number of doses of urokinase was 5.66 doses (1-12). More fluid was
      drained with the use of urokinase [594 ml (25-4575 ml) vs. 195 ml (10-1426 ml);
      p=0.006], but this did not influence the rate of resolution of fever or the
      length of hospital stay. A pathogen was isolated in 42.9% of the urokinase group 
      and 68% of the surgical group which approached statistical significance
      [p=0.054]. CONCLUSIONS: Both large bore surgical drains and "pigtail catheter"
      drains with the instillation of urokinase lead to similarly favourable treatment 
      outcomes. Either treatment could be recommended depending on local expertise and 
      preferences.
CI  - (c) 2010 The Authors. Journal of Paediatrics and Child Health (c) 2010
      Paediatrics and Child Health Division (Royal Australasian College of Physicians).
FAU - van Loo, Anouk
AU  - van Loo A
AD  - Maastricht University, the Netherlands University of Sydney The Children's
      Hospital at Westmead, Sydney, New South Wales, Australia.
FAU - van Loo, Eva
AU  - van Loo E
FAU - Selvadurai, Hiran
AU  - Selvadurai H
FAU - Cooper, Peter
AU  - Cooper P
FAU - Van Asperen, Peter
AU  - Van Asperen P
FAU - Fitzgerald, Dominic A
AU  - Fitzgerald DA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20101229
PL  - Australia
TA  - J Paediatr Child Health
JT  - Journal of paediatrics and child health
JID - 9005421
RN  - EC 3.4.21.73 (Urokinase-Type Plasminogen Activator)
SB  - IM
MH  - Australia
MH  - Catheters
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Drainage/methods
MH  - Drug Administration Schedule
MH  - Empyema, Pleural/diagnosis/*drug therapy/*surgery
MH  - Female
MH  - Follow-Up Studies
MH  - Hospitals, Pediatric
MH  - Humans
MH  - Infant
MH  - Instillation, Drug
MH  - Male
MH  - Radiography, Thoracic/methods
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Severity of Illness Index
MH  - Thoracic Surgery, Video-Assisted/*methods
MH  - Tomography, X-Ray Computed/methods
MH  - Treatment Outcome
MH  - Ultrasonography, Doppler
MH  - Urokinase-Type Plasminogen Activator/*therapeutic use
OTO - NOTNLM
OT  - empyema
OT  - retrospective study
OT  - surgical procedure
OT  - urokinase
EDAT- 2011/01/05 06:00
MHDA- 2015/06/18 06:00
CRDT- 2011/01/05 06:00
PHST- 2011/01/05 06:00 [entrez]
PHST- 2011/01/05 06:00 [pubmed]
PHST- 2015/06/18 06:00 [medline]
AID - 10.1111/j.1440-1754.2010.01931.x [doi]
PST - ppublish
SO  - J Paediatr Child Health. 2014 Oct;50(10):823-6. doi:
      10.1111/j.1440-1754.2010.01931.x. Epub 2010 Dec 29.


PMID- 21198817
OWN - NLM
STAT- MEDLINE
DCOM- 20110421
LR  - 20110104
IS  - 1525-1446 (Electronic)
IS  - 0737-1209 (Linking)
VI  - 28
IP  - 1
DP  - 2011 Jan-Feb
TI  - The ethics of sin taxes.
PG  - 68-77
LID - 10.1111/j.1525-1446.2010.00907.x [doi]
AB  - ABSTRACT The current global economic crisis is forcing governments to consider a 
      variety of methods to generate funds for infrastructure. In the United States,
      smoking-related illness and an obesity epidemic are forcing public health
      institutions to consider a variety of methods to influence health behaviors of
      entire target groups. In this paper, the author uses a public health nursing
      model, the Public Health Code of Ethics (Public Health Leadership Society, 2002),
      the American Nurses' Association (ANA) Code of Ethics (2001), and other relevant 
      ethical theory to weigh and balance the arguments for and against the use of sin 
      taxes. A position advocating the limited use of sin taxes is supported as a
      reasonable stance for the public health professional.
CI  - (c) 2010 Wiley Periodicals, Inc.
FAU - Green, Rebecca
AU  - Green R
AD  - Kennesaw State University, Kennesaw, Georgia, USA. stoltzfusgreen@aol.com
LA  - eng
PT  - Journal Article
DEP - 20101006
PL  - United States
TA  - Public Health Nurs
JT  - Public health nursing (Boston, Mass.)
JID - 8501498
SB  - IM
MH  - *Ethics, Medical
MH  - Health Policy/economics/*legislation & jurisprudence
MH  - Humans
MH  - Morals
MH  - Personal Autonomy
MH  - Public Health Nursing/economics/*ethics/legislation & jurisprudence
MH  - Public Health Practice/economics/ethics/statistics & numerical data
MH  - Risk Assessment/ethics/*methods
MH  - Risk Reduction Behavior
MH  - Risk-Taking
MH  - Social Responsibility
MH  - Taxes/*legislation & jurisprudence
MH  - United States
EDAT- 2011/01/05 06:00
MHDA- 2011/04/22 06:00
CRDT- 2011/01/05 06:00
PHST- 2011/01/05 06:00 [entrez]
PHST- 2011/01/05 06:00 [pubmed]
PHST- 2011/04/22 06:00 [medline]
AID - 10.1111/j.1525-1446.2010.00907.x [doi]
PST - ppublish
SO  - Public Health Nurs. 2011 Jan-Feb;28(1):68-77. doi:
      10.1111/j.1525-1446.2010.00907.x. Epub 2010 Oct 6.


PMID- 21197315
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20220318
IS  - 1178-7090 (Electronic)
IS  - 1178-7090 (Linking)
VI  - 3
DP  - 2010 Jul 23
TI  - Comparison of the effects of dietary factors in the management and prophylaxis of
      migraine.
PG  - 125-30
AB  - Migraine is defined as a disorder characterized by intermittent headache
      episodes, accompanied with nausea, photophobia and/or phonophobia.
      Pharmacological therapy is in accordance with the severity of pain and may
      include acute, prophylactic and most commonly both approaches. The aim of the
      acute therapy is stopping or alleviating the attack or progression of the pain
      and, in case of a migraine attack that has started, lessening the pain.
      Preventive therapy aims to reduce attack frequency and severity. This study was
      designed to evaluate the effect of dietary factors in the management and
      prophylaxis of migraine in cases diagnosed as having migraine disorder according 
      to the 2003-IHS criteria. Fifty consecutive Turkish patients (13 men, 37 women)
      with diagnosis of migraine were randomly divided into two groups for treatment
      protocols with the written approval of the ethics committee. The cases in the
      first group (K) were treated with metoprolol, vitamin B(2) (riboflavin), and
      naproxen sodium just at the aura or at the beginning of the attacks. The cases in
      the second group (D) were also supplied with a comprehensive dietary list
      arranged by our algology clinic in addition to the same medication protocol.
      There were no demographic differences between the cases (P > 0.05). VAS scores
      were lower in group D than group K (P < 0.01), and also the migraine attack
      frequencies and monthly amounts of analgesic consumed amounts were also
      statistically significantly less. It was concluded that beta-blocker and
      riboflavin therapy supplemented with a convenient diet with appropriate
      alternatives in patients with migraine disorder was associated with statistically
      significant decreases in headache frequency, intensity, duration and medication
      intake.
FAU - Zencirci, Beyazit
AU  - Zencirci B
AD  - Department of Anesthesiology and Reanimation, Medical Faculty of Sutcu Imam
      University, Kahramanmaras, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20100723
PL  - New Zealand
TA  - J Pain Res
JT  - Journal of pain research
JID - 101540514
PMC - PMC3004646
OTO - NOTNLM
OT  - food intake
OT  - migraine
OT  - trigger
EDAT- 2011/01/05 06:00
MHDA- 2011/01/05 06:01
CRDT- 2011/01/04 06:00
PHST- 2010/07/22 00:00 [received]
PHST- 2011/01/04 06:00 [entrez]
PHST- 2011/01/05 06:00 [pubmed]
PHST- 2011/01/05 06:01 [medline]
AID - 10.2147/jpr.s9437 [doi]
PST - epublish
SO  - J Pain Res. 2010 Jul 23;3:125-30. doi: 10.2147/jpr.s9437.


PMID- 21197199
OWN - NLM
STAT- MEDLINE
DCOM- 20110124
LR  - 20211020
IS  - 0008-5286 (Print)
IS  - 0008-5286 (Linking)
VI  - 51
IP  - 10
DP  - 2010 Oct
TI  - Veterinary medical ethics: An ethicist's commentary on the double standard in
      veterinary medicine.
PG  - 1067-70
FAU - Rollin, Bernard E
AU  - Rollin BE
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Vet J
JT  - The Canadian veterinary journal = La revue veterinaire canadienne
JID - 0004653
SB  - IM
MH  - Animals
MH  - Canada
MH  - Clinical Competence/*economics
MH  - Education, Veterinary/*standards
MH  - Humans
MH  - Veterinarians/*ethics/psychology
MH  - *Veterinary Medicine/economics/ethics/methods/standards
PMC - PMC2942044
EDAT- 2011/01/05 06:00
MHDA- 2011/01/25 06:00
CRDT- 2011/01/04 06:00
PHST- 2011/01/04 06:00 [entrez]
PHST- 2011/01/05 06:00 [pubmed]
PHST- 2011/01/25 06:00 [medline]
PST - ppublish
SO  - Can Vet J. 2010 Oct;51(10):1067-70.


PMID- 21197189
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1935-469X (Electronic)
IS  - 1554-7477 (Linking)
VI  - 6
IP  - 5
DP  - 2010 Sep
TI  - Ethical challenges: oncologists' role in immigrant health care.
PG  - 247-8
LID - 10.1200/JOP.000129 [doi]
AB  - As health care and immigration policies evolve, oncologists may be faced with
      challenges regarding care for undocumented immigrants, and must stay abreast of
      changes in federal and state legal statutes as well as medical ethics guidelines.
FAU - Jepson, Victoria A
AU  - Jepson VA
FAU - Cox, John V
AU  - Cox JV
FAU - Peppercorn, Jeffrey
AU  - Peppercorn J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Oncol Pract
JT  - Journal of oncology practice
JID - 101261852
PMC - PMC2936468
EDAT- 2011/01/05 06:00
MHDA- 2011/01/05 06:01
CRDT- 2011/01/04 06:00
PHST- 2010/07/27 00:00 [accepted]
PHST- 2011/01/04 06:00 [entrez]
PHST- 2011/01/05 06:00 [pubmed]
PHST- 2011/01/05 06:01 [medline]
AID - 10.1200/JOP.000129 [doi]
PST - ppublish
SO  - J Oncol Pract. 2010 Sep;6(5):247-8. doi: 10.1200/JOP.000129.


PMID- 21197127
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120906
LR  - 20211020
IS  - 1548-8519 (Electronic)
IS  - 1058-1243 (Linking)
VI  - 19
IP  - 1
DP  - 2010 Winter
TI  - Parent Involvement in End-of-Life Care and Decision Making in the Newborn
      Intensive Care Unit: An Integrative Review.
PG  - 29-39
LID - 10.1624/105812410X481546 [doi]
AB  - Survival rates for very preterm and critically ill infants are increasing,
      raising complex ethical issues for health-care providers and parents who face the
      challenge of making end-of-life decisions for newborns. The purpose of this
      integrative literature review was to evaluate parental involvement in end-of-life
      care and decision making for their infant in the newborn intensive care unit.
      Findings revealed that establishing good relationships and clear communication
      between health-care providers and parents builds trust and eases stress placed on
      parents making decisions about the care of their infant. Palliative care programs
      provide support for parents and facilitate their decision making. Parents can be 
      educated about how to communicate with health-care providers. Educating nurses on
      how to provide end-of-life care may also help improve support for parents during 
      this difficult time. Additional research is recommended to examine parents' needs
      during and after end-of-life care decisions for their newborn.
FAU - Eden, Lacey M
AU  - Eden LM
AD  - LACEY M. EDEN is a staff nurse in the Intermountain Healthcare Urban South
      Newborn Intensive Care Unit in Provo, Utah, and a recent graduate as a family
      nurse practitioner. LYNN CLARK CALLISTER is a professor of maternal/newborn
      nursing at Brigham Young University College of Nursing in Provo, Utah, and a
      fellow in the American Academy of Nursing. She serves on the March of Dimes
      Bioethics Council and the March of Dimes National Nurses Advisory Council .
FAU - Callister, Lynn Clark
AU  - Callister LC
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Perinat Educ
JT  - The Journal of perinatal education
JID - 9301158
PMC - PMC2820356
OTO - NOTNLM
OT  - childbirth education
OT  - communication
OT  - newborn intensive care unit
OT  - palliative care
OT  - parent decision making
EDAT- 2011/01/05 06:00
MHDA- 2011/01/05 06:01
CRDT- 2011/01/04 06:00
PHST- 2011/01/04 06:00 [entrez]
PHST- 2011/01/05 06:00 [pubmed]
PHST- 2011/01/05 06:01 [medline]
AID - 10.1624/105812410X481546 [doi]
PST - ppublish
SO  - J Perinat Educ. 2010 Winter;19(1):29-39. doi: 10.1624/105812410X481546.


PMID- 21197081
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2011
DP  - 2011
TI  - The ethics of traditional chinese and Western herbal medicine research: views of 
      researchers and human ethics committees in australia.
PG  - 256915
LID - 10.1155/2011/256915 [doi]
AB  - Despite the growth of traditional Chinese medicine (TCM) and western herbal
      medicine (WHM) research in Australia, little is known about how ethics committees
      (HRECs) assess the ethics of TCM or WHM research. The objectives of this study
      were to examine the experiences of TCM and WHM researchers and HRECs with the
      evaluation of ethics applications. Two cross-sectional surveys were undertaken of
      HRECs and TCM and WHM researchers in Australia. Anonymous self-completion
      questionnaires were administered to 224 HRECs and 117 researchers. A response
      confirming involvement in TCM or WHM research applications was received from 20
      HRECs and 42 researchers. The most frequent ethical issues identified by HRECs
      related to herbal products including information gaps relating to mode of action 
      of herbal medicines and safety when combining herbal ingredients. Researchers
      concurred that they were frequently requested to provide additional information
      on multiple aspects including safety relating to the side effects of herbs and
      herb-drug interactions. Overall adherence with the principles of ethical conduct 
      was high among TCM and WHM researchers although our study did identify the need
      for additional information regarding assessment of risk and risk management.
FAU - Smith, Caroline A
AU  - Smith CA
AD  - Centre for Complementary Medicine Research, The University of Western Sydney,
      Locked Bag 1797, Penrith South DC, NSW 2751, Australia.
FAU - Priest, Ros
AU  - Priest R
FAU - Carmady, Bridget
AU  - Carmady B
FAU - Bourchier, Suzannah
AU  - Bourchier S
FAU - Bensoussan, Alan
AU  - Bensoussan A
LA  - eng
PT  - Journal Article
DEP - 20101213
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC3004390
EDAT- 2011/01/05 06:00
MHDA- 2011/01/05 06:01
CRDT- 2011/01/04 06:00
PHST- 2010/05/17 00:00 [received]
PHST- 2010/09/29 00:00 [revised]
PHST- 2010/11/07 00:00 [accepted]
PHST- 2011/01/04 06:00 [entrez]
PHST- 2011/01/05 06:00 [pubmed]
PHST- 2011/01/05 06:01 [medline]
AID - 10.1155/2011/256915 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2011;2011:256915. doi: 10.1155/2011/256915.
      Epub 2010 Dec 13.


PMID- 21196904
OWN - NLM
STAT- MEDLINE
DCOM- 20110418
LR  - 20110103
IS  - 0026-4806 (Print)
IS  - 0026-4806 (Linking)
VI  - 101
IP  - 6
DP  - 2010 Dec
TI  - Ethical models in bioethics: theory and application in organ allocation policies.
PG  - 445-56
AB  - Policies for allocating organs to people awaiting a transplant constitute a major
      ethical challenge. First and foremost, they demand balance between the principles
      of beneficence and justice, but many other ethically relevant principles are also
      involved: autonomy, responsibility, equity, efficiency, utility, therapeutic
      outcome, medical urgency, and so forth. Various organ allocation models can be
      developed based on the hierarchical importance assigned to a given principle over
      the others, but none of the principles should be completely disregarded. An
      ethically acceptable organ allocation policy must therefore be in conformity, to 
      a certain extent, with the requirements of all the principles. Many models for
      organ allocation can be derived. The utilitarian model aims to maximize benefits,
      which can be of various types on a social or individual level, such as the number
      of lives saved, prognosis, and so forth. The prioritarian model favours the
      neediest or those who suffer most. The egalitarian model privileges equity and
      justice, suggesting that all people should have an equal opportunity (casual
      allocation) or priority should be given to those who have been waiting longer.
      The personalist model focuses on each individual patient, attempting to mesh
      together all the various aspects affecting the person: therapeutic needs
      (urgency), fairness, clinical outcomes, respect for persons. In the
      individualistic model the main element is free choice and the system of opting-in
      is privileged. Contrary to the individualistic model, the communitarian model
      identities in the community the fundamental elements for the legitimacy of
      choices: therefore, the system of opting-out is privileged. This article does not
      aim at suggesting practical solutions. Rather, it furnishes to decision makers an
      overview on the possible ethical approach to this matter.
FAU - Petrini, C
AU  - Petrini C
AD  - National Institute of Health, Rome, Italy. carlo.petrini@iss.it
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - Minerva Med
JT  - Minerva medica
JID - 0400732
SB  - IM
MH  - Bioethical Issues/*standards
MH  - Decision Making/ethics
MH  - *Ethical Theory
MH  - Humans
MH  - Organ Transplantation/*ethics
MH  - Patient Selection/*ethics
MH  - Resource Allocation/*ethics
MH  - Social Justice/ethics
EDAT- 2011/01/05 06:00
MHDA- 2011/04/19 06:00
CRDT- 2011/01/04 06:00
PHST- 2011/01/04 06:00 [entrez]
PHST- 2011/01/05 06:00 [pubmed]
PHST- 2011/04/19 06:00 [medline]
AID - R10113061 [pii]
PST - ppublish
SO  - Minerva Med. 2010 Dec;101(6):445-56.


PMID- 21196805
OWN - NLM
STAT- MEDLINE
DCOM- 20110627
LR  - 20131121
IS  - 1423-0348 (Electronic)
IS  - 0033-3190 (Linking)
VI  - 80
IP  - 2
DP  - 2011
TI  - Health effects on leaders and co-workers of an art-based leadership development
      program.
PG  - 78-87
LID - 10.1159/000321557 [doi]
AB  - BACKGROUND: There are very few evaluations of the effectiveness of leadership
      development programs. The purpose of the study was to examine whether an
      art-based leadership program may have a more beneficial effect than a
      conventional one on leaders' and their corresponding subordinates' mental and
      biological stress. METHODS: Participating leaders were randomized to 2 year-long 
      leadership programs, 1 art-based and 1 conventional, with follow-up of the
      leaders and their subordinates at 12 and 18 months. The art-based program built
      on an experimental theatre form, a collage of literary text and music, followed
      by writing and discussions focused on existential and ethical problems. RESULTS: 
      After 18 months a pattern was clearly visible with advantage for the art-based
      group. In the art group (leaders and their subordinates together as well as for
      subordinates only) compared to the conventional group, there was a significant
      improvement of mental health, covert coping and performance-based self-esteem as 
      well as significantly less winter/fall deterioration in the serum concentration
      of the regenerative/anabolic hormone dehydroepiandrosterone-sulfate. CONCLUSIONS:
      Our findings indicate a more beneficial long-term health effect of the art-based 
      intervention compared to a conventional approach. Positive results for both
      standardized questionnaires and biological parameters strengthened the findings. 
      The study provides a rationale for further evaluation of the effectiveness of
      this alternative educational approach.
CI  - Copyright (c) 2010 S. Karger AG, Basel.
FAU - Romanowska, Julia
AU  - Romanowska J
AD  - Department of Public Health Sciences, Karolinska Institutet, Stockholm
      University, Stockholm, Sweden. julia@romanowska.com
FAU - Larsson, Gerry
AU  - Larsson G
FAU - Eriksson, Maria
AU  - Eriksson M
FAU - Wikstrom, Britt-Maj
AU  - Wikstrom BM
FAU - Westerlund, Hugo
AU  - Westerlund H
FAU - Theorell, Tores
AU  - Theorell T
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20101223
PL  - Switzerland
TA  - Psychother Psychosom
JT  - Psychotherapy and psychosomatics
JID - 0024046
RN  - 57B09Q7FJR (Dehydroepiandrosterone Sulfate)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adaptation, Psychological/physiology
MH  - Adult
MH  - Arousal/*physiology
MH  - *Art
MH  - Burnout, Professional/blood/prevention & control/psychology
MH  - Curriculum
MH  - Dehydroepiandrosterone Sulfate/*blood
MH  - Depression/blood/prevention & control/psychology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hydrocortisone/*blood
MH  - Inservice Training/*methods
MH  - *Job Satisfaction
MH  - *Leadership
MH  - Male
MH  - Personnel Management/*methods
MH  - Seasons
MH  - Sleep Initiation and Maintenance Disorders/blood/prevention & control/psychology
MH  - Social Responsibility
MH  - Stress, Psychological/*complications/*prevention & control
MH  - Sweden
EDAT- 2011/01/05 06:00
MHDA- 2011/06/28 06:00
CRDT- 2011/01/04 06:00
PHST- 2009/07/27 00:00 [received]
PHST- 2010/09/15 00:00 [accepted]
PHST- 2011/01/04 06:00 [entrez]
PHST- 2011/01/05 06:00 [pubmed]
PHST- 2011/06/28 06:00 [medline]
AID - 000321557 [pii]
AID - 10.1159/000321557 [doi]
PST - ppublish
SO  - Psychother Psychosom. 2011;80(2):78-87. doi: 10.1159/000321557. Epub 2010 Dec 23.


PMID- 21195626
OWN - NLM
STAT- MEDLINE
DCOM- 20120123
LR  - 20161125
IS  - 1878-4119 (Electronic)
IS  - 1010-5182 (Linking)
VI  - 39
IP  - 7
DP  - 2011 Oct
TI  - Psychological care for maxillofacial trauma patients: a preliminary survey of
      oral and maxillofacial surgeons.
PG  - 515-8
LID - 10.1016/j.jcms.2010.11.007 [doi]
AB  - INTRODUCTION: Psychological morbidities are major complications following
      maxillofacial injuries. The aim of this study was to assess self-evaluation of
      oral and maxillofacial surgeons on posttraumatic psychological care. METHODS:
      Using a cross-sectional study design, we enrolled a sample of surgeons in 261
      oral and maxillofacial surgery (OMFS) departments in the United States, United
      Kingdom and France. A self-administered e-mail questionnaire was used to evaluate
      knowledge, attitude and practice of the surgeons regarding psychological problems
      in maxillofacial injury patients, and their collaboration with psychological
      personnel. Appropriate descriptive and univariate statistics were computed, and
      P<0.05 was considered statistically significant. RESULTS: The response rate was
      28.1% (112 of 398), but we included only 100 respondents from 107 OMS units. 60% 
      of the surgeons disclosed a moderate or high level of relevant knowledge. Only 28
      OMS departments (26.2%) had intra-service psychological staff (commonly in France
      [P<0.05]), and five surgeons revealed considerable deficits in access to
      psychological care. Frequent reasons for patient referral to psychological staff 
      were depression, body dysmorphic disorder, posttraumatic stress disorder,
      suicidal idea, anxiety and behavioural changes. Eighty-eight surgeons linked
      patient's non-compliance with changes or difficulties in practice, and 58
      surgeons experienced it already. CONCLUSIONS: Despite several limitations, the
      results of this study suggest that oral and maxillofacial surgeons have a great
      interest and experience in posttraumatic psychological problems. Psychological
      professionals in charge will improve surgical care quality. Well-designed studies
      with larger sample size are desirable to confirm our results. Ethical issues of
      maxillofacial trauma care are also discussed.
CI  - Copyright (c) 2010 European Association for Cranio-Maxillo-Facial Surgery.
      Published by Elsevier Ltd. All rights reserved.
FAU - Pitak-Arnnop, Poramate
AU  - Pitak-Arnnop P
AD  - Department of Oral, Craniomaxillofacial and Facial Plastic Surgery, Faculty of
      Medicine, University Hospital of Leipzig, Nurnberger Strasse 57, Leipzig,
      Germany. poramate.pitakarnnop@gmail.com
FAU - Herve, Christian
AU  - Herve C
FAU - Coffin, Jean-Christophe
AU  - Coffin JC
FAU - Dhanuthai, Kittipong
AU  - Dhanuthai K
FAU - Bertrand, Jacques-Charles
AU  - Bertrand JC
FAU - Meningaud, Jean-Paul
AU  - Meningaud JP
LA  - eng
PT  - Journal Article
DEP - 20101231
PL  - Scotland
TA  - J Craniomaxillofac Surg
JT  - Journal of cranio-maxillo-facial surgery : official publication of the European
      Association for Cranio-Maxillo-Facial Surgery
JID - 8704309
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Chi-Square Distribution
MH  - Cross-Sectional Studies
MH  - France
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Maxillofacial Injuries/complications/*psychology/surgery
MH  - *Practice Patterns, Dentists'/statistics & numerical data
MH  - Psychotherapy
MH  - Referral and Consultation/statistics & numerical data
MH  - Stress Disorders, Post-Traumatic/etiology/*therapy
MH  - *Surgery, Oral/ethics/psychology/statistics & numerical data
MH  - Surveys and Questionnaires
MH  - United Kingdom
MH  - United States
EDAT- 2011/01/05 06:00
MHDA- 2012/01/24 06:00
CRDT- 2011/01/04 06:00
PHST- 2009/03/10 00:00 [received]
PHST- 2010/10/18 00:00 [revised]
PHST- 2010/11/26 00:00 [accepted]
PHST- 2011/01/04 06:00 [entrez]
PHST- 2011/01/05 06:00 [pubmed]
PHST- 2012/01/24 06:00 [medline]
AID - S1010-5182(10)00224-6 [pii]
AID - 10.1016/j.jcms.2010.11.007 [doi]
PST - ppublish
SO  - J Craniomaxillofac Surg. 2011 Oct;39(7):515-8. doi: 10.1016/j.jcms.2010.11.007.
      Epub 2010 Dec 31.


PMID- 21195160
OWN - NLM
STAT- MEDLINE
DCOM- 20110623
LR  - 20110304
IS  - 1879-3177 (Electronic)
IS  - 0887-2333 (Linking)
VI  - 25
IP  - 3
DP  - 2011 Apr
TI  - The intra- and inter-laboratory reproducibility and predictivity of the
      KeratinoSens assay to predict skin sensitizers in vitro: results of a ring-study 
      in five laboratories.
PG  - 733-44
LID - 10.1016/j.tiv.2010.12.014 [doi]
AB  - Due to regulatory constraints and ethical considerations, research on
      alternatives to animal testing to predict the skin sensitization potential of
      novel chemicals has gained a high priority. Accordingly, different in vitro, in
      silico and in chemico approaches have been described in the scientific literature
      to achieve this goal. To replace regulatory approved animal tests, these
      alternatives need to be transferable to other labs, their within and between
      laboratory reproducibility must be assured, and their predictivity should be
      high. The KeratinoSens assay is a cell-based reporter gene assay to screen
      substances with a full dose-response assessment. It is based on a stable
      transgenic keratinocyte cell line. The induction of a luciferase gene under the
      control of the antioxidant response element (ARE) derived from the human AKR1C2
      gene is determined. Here we report on the results of a ring-study with five
      laboratories performing the KeratinoSens assay on a set of 28 test substances.
      The assay was found to be easily transferable to all laboratories. Overall both
      the qualitative (sensitizer/non-sensitizer categorization) and the quantitative
      (concentration for significant gene induction) results were reproducible between 
      laboratories. A detailed analysis of the transferability, the within- and between
      laboratory reproducibility and the predictivity is presented.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Andreas, Natsch
AU  - Andreas N
AD  - Givaudan Schweiz AG, Ueberlandstrasse 138, CH-8600 Duebendorf, Switzerland.
      andreas.natsch@givaudan.com
FAU - Caroline, Bauch
AU  - Caroline B
FAU - Leslie, Foertsch
AU  - Leslie F
FAU - Frank, Gerberick
AU  - Frank G
FAU - Kimberly, Norman
AU  - Kimberly N
FAU - Allison, Hilberer
AU  - Allison H
FAU - Heather, Inglis
AU  - Heather I
FAU - Robert, Landsiedel
AU  - Robert L
FAU - Stefan, Onken
AU  - Stefan O
FAU - Hendrik, Reuter
AU  - Hendrik R
FAU - Andreas, Schepky
AU  - Andreas S
FAU - Roger, Emter
AU  - Roger E
LA  - eng
PT  - Journal Article
DEP - 20101230
PL  - England
TA  - Toxicol In Vitro
JT  - Toxicology in vitro : an international journal published in association with
      BIBRA
JID - 8712158
RN  - 0 (Allergens)
RN  - 0 (Xenobiotics)
RN  - EC 1.13.12.- (Luciferases)
SB  - IM
MH  - Allergens/classification/*toxicity
MH  - Animal Testing Alternatives
MH  - Cell Line
MH  - Dermatitis, Contact/etiology/*prevention & control
MH  - Gene Expression Regulation/drug effects
MH  - Genes, Reporter
MH  - High-Throughput Screening Assays
MH  - Humans
MH  - *Immunization
MH  - Keratinocytes/*drug effects
MH  - Luciferases/biosynthesis/genetics
MH  - Predictive Value of Tests
MH  - Reproducibility of Results
MH  - Skin Tests
MH  - Xenobiotics/classification/*toxicity
EDAT- 2011/01/05 06:00
MHDA- 2011/06/24 06:00
CRDT- 2011/01/04 06:00
PHST- 2010/10/04 00:00 [received]
PHST- 2010/12/06 00:00 [revised]
PHST- 2010/12/20 00:00 [accepted]
PHST- 2011/01/04 06:00 [entrez]
PHST- 2011/01/05 06:00 [pubmed]
PHST- 2011/06/24 06:00 [medline]
AID - S0887-2333(10)00341-3 [pii]
AID - 10.1016/j.tiv.2010.12.014 [doi]
PST - ppublish
SO  - Toxicol In Vitro. 2011 Apr;25(3):733-44. doi: 10.1016/j.tiv.2010.12.014. Epub
      2010 Dec 30.


PMID- 21194921
OWN - NLM
STAT- MEDLINE
DCOM- 20110815
LR  - 20110404
IS  - 1532-3374 (Electronic)
IS  - 0959-289X (Linking)
VI  - 20
IP  - 2
DP  - 2011 Apr
TI  - A randomised, double-blinded, placebo-controlled study of acupressure wristbands 
      for the prevention of nausea and vomiting during labour and delivery.
PG  - 110-7
LID - 10.1016/j.ijoa.2010.10.005 [doi]
AB  - INTRODUCTION: Approximately 50% of women experience nausea or vomiting during
      labour. P6 acupoint stimulation reduces postoperative nausea and vomiting in
      early pregnancy and after chemotherapy. The aim of this randomised,
      double-blinded, placebo-controlled trial was to determine whether P6 acupressure 
      prevented nausea and vomiting during labour and delivery. METHODS: After ethical 
      approval and informed consent, women admitted for induction of labour, or in
      spontaneous labour, were randomised to receive either acupressure bands (Pressure
      Right) (Group A) or sham placebo bands (Group P) applied to each wrist.
      Exclusions included recent nausea or vomiting. RESULTS: We consented 365 women
      and randomised 340 (170 per group). The groups had similar patient and labour
      characteristics. The incidence of nausea and/or vomiting did not significantly
      differ (Group A 53% vs. Group P 50%, P=0.58). There was no significant difference
      between groups (A vs. P, respectively) in the incidence of nausea (52% vs. 45%), 
      vomiting (27% vs. 28%), rescue antiemetic treatment (27% in both), severity of
      nausea or vomiting, satisfaction with control of nausea or ratings of
      inconvenience or discomfort from the bands (10% vs. 11%). Factors significantly
      associated with emetic symptoms were smoking (OR 2.16, 95% CI 1.07-4.37), opioid 
      analgesia (OR 1.95, 95% CI 1.06-3.59), history of motion-induced or postoperative
      nausea and vomiting (OR 1.85, 95% CI 1.17-2.94) and higher body mass index (OR
      1.07, 95% CI 1.01-1.12). CONCLUSION: In this study acupressure wristbands applied
      bilaterally did not reduce the incidence of nausea and vomiting during labour and
      delivery.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Sinha, A
AU  - Sinha A
AD  - Department of Anaesthesia and Pain Medicine, King Edward Memorial Hospital for
      Women, Western Australia, Australia.
FAU - Paech, M J
AU  - Paech MJ
FAU - Thew, M E
AU  - Thew ME
FAU - Rhodes, M
AU  - Rhodes M
FAU - Luscombe, K
AU  - Luscombe K
FAU - Nathan, E
AU  - Nathan E
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20101230
PL  - Netherlands
TA  - Int J Obstet Anesth
JT  - International journal of obstetric anesthesia
JID - 9200430
SB  - IM
MH  - *Acupressure
MH  - Adult
MH  - Anesthesia, Obstetrical/*adverse effects
MH  - Delivery, Obstetric
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Nausea/*prevention & control
MH  - Pregnancy
MH  - Prospective Studies
MH  - Vomiting/*prevention & control
MH  - *Wrist
EDAT- 2011/01/05 06:00
MHDA- 2011/08/16 06:00
CRDT- 2011/01/04 06:00
PHST- 2010/04/05 00:00 [received]
PHST- 2010/10/10 00:00 [revised]
PHST- 2010/10/13 00:00 [accepted]
PHST- 2011/01/04 06:00 [entrez]
PHST- 2011/01/05 06:00 [pubmed]
PHST- 2011/08/16 06:00 [medline]
AID - S0959-289X(10)00165-2 [pii]
AID - 10.1016/j.ijoa.2010.10.005 [doi]
PST - ppublish
SO  - Int J Obstet Anesth. 2011 Apr;20(2):110-7. doi: 10.1016/j.ijoa.2010.10.005. Epub 
      2010 Dec 30.


PMID- 21194888
OWN - NLM
STAT- MEDLINE
DCOM- 20110301
LR  - 20171116
IS  - 1878-5921 (Electronic)
IS  - 0895-4356 (Linking)
VI  - 64
IP  - 3
DP  - 2011 Mar
TI  - Trade-off between benefit and harm is crucial in health screening
      recommendations. Part II: evidence summaries.
PG  - 240-9
LID - 10.1016/j.jclinepi.2010.09.008 [doi]
AB  - Evidence on the effectiveness of health screening strategies may be direct (i.e.,
      studies on screening vs. no screening) or indirect (i.e., studies that separately
      evaluate the screening test[s], the confirmatory test, or the treatment).
      Critical trade-offs in the balance between harm and benefit for many screening
      strategies mandate that advocates of health screening adhere to the ethical
      precepts of nonmaleficence, autonomy, confidentiality, and equity. In our first
      article, we pointed out five prerequisites to justifying a health screening
      program: (1) the burden of illness should be high, (2) the screening and
      confirmatory tests should be accurate, (3) early treatment (or prevention) must
      be more effective than late treatment, (4) the tests and the treatment(s) must be
      safe, and (5) the cost of the screening strategy must be commensurate with the
      potential benefit. As can be gleaned from these criteria, recommendations on
      screening must be tailored to specific populations. Recommendations in one
      country, no matter how authoritative, cannot be generalized to apply to all other
      countries. Although accuracy, effectiveness, and safety data may be global
      (criteria 2-4), burden of illness and efficiency (criteria 1 and 5) will always
      vary from country to country. Rather than review various national guidelines, in 
      this last article of our two-part series, we present evidence summaries to
      illustrate health screening. Our examples were selected to address special issues
      related to four situations-screening for cancer, risk factors for disease,
      genetic disorders, and infectious diseases.
CI  - Copyright A(c) 2011 Elsevier Inc. All rights reserved.
FAU - Silvestre, Maria Asuncion A
AU  - Silvestre MA
AD  - University of the Philippines Manila, Philippines.
FAU - Dans, Leonila F
AU  - Dans LF
FAU - Dans, Antonio L
AU  - Dans AL
LA  - eng
PT  - Journal Article
DEP - 20101230
PL  - United States
TA  - J Clin Epidemiol
JT  - Journal of clinical epidemiology
JID - 8801383
SB  - IM
CIN - J Clin Epidemiol. 2011 Oct;64(10):1161; author reply 1161-2. PMID: 21665434
MH  - Bias
MH  - Bioethical Issues
MH  - Breast Neoplasms/diagnosis/psychology
MH  - Cost of Illness
MH  - *Evidence-Based Practice
MH  - Female
MH  - Genetic Diseases, Inborn/diagnosis/psychology
MH  - Humans
MH  - *Mass Screening/ethics/methods/psychology
MH  - Risk Factors
EDAT- 2011/01/05 06:00
MHDA- 2011/03/02 06:00
CRDT- 2011/01/04 06:00
PHST- 2010/09/24 00:00 [received]
PHST- 2010/09/27 00:00 [accepted]
PHST- 2011/01/04 06:00 [entrez]
PHST- 2011/01/05 06:00 [pubmed]
PHST- 2011/03/02 06:00 [medline]
AID - S0895-4356(10)00318-5 [pii]
AID - 10.1016/j.jclinepi.2010.09.008 [doi]
PST - ppublish
SO  - J Clin Epidemiol. 2011 Mar;64(3):240-9. doi: 10.1016/j.jclinepi.2010.09.008. Epub
      2010 Dec 30.


PMID- 21194558
OWN - NLM
STAT- MEDLINE
DCOM- 20120103
LR  - 20181201
IS  - 1873-2747 (Electronic)
IS  - 0361-9230 (Linking)
VI  - 84
IP  - 3
DP  - 2011 Feb 28
TI  - Human umbilical cord Wharton's jelly-derived mesenchymal stem cells differentiate
      into a Schwann-cell phenotype and promote neurite outgrowth in vitro.
PG  - 235-43
LID - 10.1016/j.brainresbull.2010.12.013 [doi]
AB  - Cell-based therapy has achieved promising functional recovery for peripheral
      nerve repair. Although Schwann cells (SCs) and bone marrow derived mesenchymal
      stromal cells (BM-MSCs) are the main cell source for nerve tissue engineering,
      the clinical application is limited because of donor site morbidity, the invasive
      procedure, and the decreased number of SCs and BM-MSCs. Wharton's jelly-derived
      mesenchymal stem cells (WJMSCs) could be a promising cell source for nerve tissue
      engineering because they are easily accessible and their use has no ethical
      issues. We investigated the phenotypic, molecular and functional characteristics 
      of WJMSCs differentiated along a Schwann-cell lineage. Cultured WJMSCs were
      isolated from human umbilical cord, and the undifferentiated WJMSCs were
      confirmed by the detection of MSC-specific cell-surface markers. WJMSCs treated
      with a mixture of glial growth factors (basic fibroblast growth factor,
      platelet-derived growth factor and forskolin) adopted a spindle-like morphology
      similar to SCs. Immunocytochemical staining, RT-PCR analysis, and Western blot
      analysis revealed that the treated cells expressed the glial markers glial
      fibrillary acidic protein, p75, S100 and P0 and indicative of differentiation. On
      co-culture with dorsal root ganglia neurons, the differentiated WJMSCs enhanced
      the number of sprouting neurites and neurite length in dorsal root ganglia
      neurons. Furthermore, using enzyme-linked immunosorbent assay and RT-PCR
      methodology, we found differentiated WJMSCs secrete and express neurotrophic
      factors, including brain-derived neurotrophic factor (BDNF), nerve growth factor 
      (NGF), and neurotrophin-3 (NT-3). Quantification of neurite outgrowth from PC12
      cells grown in differentiated WJMSCs-conditioned media demonstrates that the
      neurite length is significantly more than control medium and undifferentiated
      WJMSCs group. WJMSCs can be differentiated into cells that are Schwann-like in
      terms of morphologic features, phenotype, and function and could be suitable
      Schwann-cell substitutes for nerve repair in clinical applications.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Peng, Jiang
AU  - Peng J
AD  - Orthopedics Research Institute of Chinese PLA, General Hospital of Chinese PLA,
      Haidian District, Beijing, China.
FAU - Wang, Yu
AU  - Wang Y
FAU - Zhang, Li
AU  - Zhang L
FAU - Zhao, Bin
AU  - Zhao B
FAU - Zhao, Zhe
AU  - Zhao Z
FAU - Chen, JiFeng
AU  - Chen J
FAU - Guo, QuanYi
AU  - Guo Q
FAU - Liu, ShuYun
AU  - Liu S
FAU - Sui, Xiang
AU  - Sui X
FAU - Xu, WenJing
AU  - Xu W
FAU - Lu, ShiBi
AU  - Lu S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101229
PL  - United States
TA  - Brain Res Bull
JT  - Brain research bulletin
JID - 7605818
SB  - IM
MH  - Animals
MH  - Cell Differentiation/*physiology
MH  - Cell Lineage/physiology
MH  - Cells, Cultured
MH  - Coculture Techniques
MH  - Humans
MH  - Infant, Newborn
MH  - Mesenchymal Stem Cell Transplantation/*methods
MH  - Mesenchymal Stem Cells/cytology/*physiology
MH  - Nerve Regeneration/*physiology
MH  - PC12 Cells
MH  - Phenotype
MH  - Rats
MH  - Schwann Cells/cytology/*physiology
MH  - Wharton Jelly/cytology/*physiology
EDAT- 2011/01/05 06:00
MHDA- 2012/01/04 06:00
CRDT- 2011/01/04 06:00
PHST- 2010/04/03 00:00 [received]
PHST- 2010/11/24 00:00 [revised]
PHST- 2010/12/22 00:00 [accepted]
PHST- 2011/01/04 06:00 [entrez]
PHST- 2011/01/05 06:00 [pubmed]
PHST- 2012/01/04 06:00 [medline]
AID - S0361-9230(10)00298-4 [pii]
AID - 10.1016/j.brainresbull.2010.12.013 [doi]
PST - ppublish
SO  - Brain Res Bull. 2011 Feb 28;84(3):235-43. doi:
      10.1016/j.brainresbull.2010.12.013. Epub 2010 Dec 29.


PMID- 21193596
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20220409
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 258
IP  - 3
DP  - 2011 Mar
TI  - Characterization of complex adnexal masses: value of adding perfusion- and
      diffusion-weighted MR imaging to conventional MR imaging.
PG  - 793-803
LID - 10.1148/radiol.10100751 [doi]
AB  - PURPOSE: To retrospectively determine the value of adding perfusion-weighted (PW)
      and diffusion-weighted (DW) sequences to a conventional magnetic resonance (MR)
      imaging protocol to differentiate benign from malignant tumors. MATERIALS AND
      METHODS: The institutional ethics committee approved this retrospective study and
      waived the requirement to obtain informed consent. MR images in 87 women (age
      range, 25-87 years) who underwent imaging before surgery for complex adnexal
      masses-excluding endometriomas and cystic teratomas-were analyzed. Conventional
      morphologic, perfusion, and diffusion MR criteria of malignancy were recorded.
      Three independent observers reviewed images in four steps: conventional MR images
      alone, conventional MR images and PW images combined, conventional MR images and 
      DW images combined, and conventional, PW, and DW MR images combined. Receiver
      operating characteristic curve analysis was performed to compare the results of
      the readings. A recursive partitioning model was built to establish a
      multivariate decision tree. RESULTS: There was almost perfect agreement for
      lesion characterization regardless of the reader experiment or step considered
      (kappa = 0.811-0.929). Area under the receiver operating characteristic curve
      values were higher for conventional and DW images combined, conventional and PW
      images combined, and conventional, DW, and PW images combined compared with
      conventional MR images alone (P < .05). For all readers, the accuracy of
      conventional, PW, and DW imaging combined was higher than that of conventional MR
      imaging alone for benign masses (P < .01) but not for malignant masses (P = .24).
      The addition of both PW and DW images led to a correct change in the diagnosis in
      19% (11 of 57 patients), 23% (13 of 57 patients), and 24% (14 of 57 patients) of 
      cases for readers 1, 2, and 3, respectively, with no incorrect changes.
      Conventional, PW, and DW MR imaging criteria were combined to generate a decision
      tree giving an accuracy of 95%. CONCLUSION: The addition of PW and DW sequences
      to a conventional MR imaging protocol improved the diagnostic accuracy in the
      characterization of complex adnexal masses.
CI  - (c) RSNA, 2011.
FAU - Thomassin-Naggara, Isabelle
AU  - Thomassin-Naggara I
AD  - Department of Radiology, Hopital Tenon, Universite Pierre et Marie Curie, 4 rue
      de la Chine, 75020 Paris, France. isabelle.thomassin@tnn.aphp.fr
FAU - Toussaint, Irwin
AU  - Toussaint I
FAU - Perrot, Nicolas
AU  - Perrot N
FAU - Rouzier, Roman
AU  - Rouzier R
FAU - Cuenod, Charles A
AU  - Cuenod CA
FAU - Bazot, Marc
AU  - Bazot M
FAU - Darai, Emile
AU  - Darai E
LA  - eng
PT  - Journal Article
DEP - 20101230
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 6HG8UB2MUY (Meglumine)
RN  - L0ND3981AG (gadoterate meglumine)
SB  - IM
MH  - Adnexal Diseases/*diagnosis/surgery
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Contrast Media
MH  - Diffusion Magnetic Resonance Imaging/methods
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Meglumine
MH  - Middle Aged
MH  - Organometallic Compounds
MH  - ROC Curve
MH  - Retrospective Studies
EDAT- 2011/01/05 06:00
MHDA- 2011/06/03 06:00
CRDT- 2011/01/04 06:00
PHST- 2011/01/04 06:00 [entrez]
PHST- 2011/01/05 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
AID - radiol.10100751 [pii]
AID - 10.1148/radiol.10100751 [doi]
PST - ppublish
SO  - Radiology. 2011 Mar;258(3):793-803. doi: 10.1148/radiol.10100751. Epub 2010 Dec
      30.


PMID- 21192997
OWN - NLM
STAT- MEDLINE
DCOM- 20110623
LR  - 20151119
IS  - 1095-8304 (Electronic)
IS  - 0195-6663 (Linking)
VI  - 56
IP  - 2
DP  - 2011 Apr
TI  - Consumers' purchase of organic food products. A matter of convenience and
      reflexive practices.
PG  - 336-44
LID - 10.1016/j.appet.2010.12.019 [doi]
AB  - The aim of this study was to gain insight into the purchase of organic food
      products by consumers and to explore the main factors driving this process. This 
      paper uses evidence from 16 in-depth interviews with consumers in Denmark carried
      out in 2008-2009. On the basis of the analysis two broad concepts are suggested: 
      convenience behaviours and reflexive practices. Convenience behaviours are
      characteristic of pragmatic organic consumers. This type of shopping behaviour
      requires organic foods to be available in the local supermarket, they have to be 
      clearly visible (preferably with an eco-label), and the price differential
      vis-a-vis conventional products have to be minimal. The analysis also showed that
      politically/ethically minded consumers have reflexive practices when purchasing
      organic food products: health considerations, ethical considerations (animal
      welfare), political considerations (environmentalism) and quality considerations 
      (taste) play an important part for these consumers. Reflexive shopping practices 
      can be sparked by life events (e.g. having children), "shocking" news about
      conventional food products and similar events, and news capable of creating a
      "cognitive dissonance" among consumers. The Danish case illustrates that the
      government needs to actively implement reforms and promote activities which make 
      organic products a convenient choice for the pragmatic oriented consumer if their
      market share is to increase substantially.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Hjelmar, Ulf
AU  - Hjelmar U
AD  - Institute of Governmental Research (AKF), Kobmagergade 22, 1150 Copenhagen,
      Denmark. ulf@akf.dk
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101228
PL  - England
TA  - Appetite
JT  - Appetite
JID - 8006808
SB  - IM
MH  - Adult
MH  - Animal Welfare/ethics
MH  - Attitude to Health
MH  - Child
MH  - *Choice Behavior
MH  - Commerce
MH  - Consumer Behavior
MH  - Denmark
MH  - Environment
MH  - Female
MH  - Food
MH  - Food Preferences/*psychology
MH  - *Food, Organic
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Politics
MH  - *Surveys and Questionnaires
MH  - Taste
EDAT- 2011/01/05 06:00
MHDA- 2011/06/24 06:00
CRDT- 2011/01/04 06:00
PHST- 2010/03/25 00:00 [received]
PHST- 2010/11/25 00:00 [revised]
PHST- 2010/12/20 00:00 [accepted]
PHST- 2011/01/04 06:00 [entrez]
PHST- 2011/01/05 06:00 [pubmed]
PHST- 2011/06/24 06:00 [medline]
AID - S0195-6663(10)00845-7 [pii]
AID - 10.1016/j.appet.2010.12.019 [doi]
PST - ppublish
SO  - Appetite. 2011 Apr;56(2):336-44. doi: 10.1016/j.appet.2010.12.019. Epub 2010 Dec 
      28.


PMID- 21192438
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20161021
IS  - 1134-7198 (Print)
IS  - 1134-7198 (Linking)
IP  - 32
DP  - 2010 Jan-Jun
TI  - [Ethical aspects of neonatal genetic screening].
PG  - 221-41
AB  - The expansion of newborn genetic screening programs modifies the basic ethical
      criterion which has justified these interventions: the early detection to provide
      a treatment or a clinical benefit to the child. By including diseases in which
      the relationship between benefit and damage is less clear, some questions arise, 
      such as anxiety of parents for false positives, the type of information and
      advice that should be provided, if these data really represent an improvement,
      the possibility of demanding an informed consent, and if the long-term costs are 
      properly compensated, not only in economic terms but also in quality of life.
FAU - Feito Grande, Lydia
AU  - Feito Grande L
AD  - Facultad de Medicina, Universidad Complutense de Madrid, Espana.
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Aspectos eticos del cribado genetico neonatal.
PL  - Spain
TA  - Rev Derecho Genoma Hum
JT  - Revista de derecho y genoma humano = Law and the human genome review
JID - 101558644
SB  - IM
MH  - Communication
MH  - False Positive Reactions
MH  - Genetic Testing/*ethics/legislation & jurisprudence
MH  - Humans
MH  - Infant, Newborn
MH  - Neonatal Screening/*ethics/legislation & jurisprudence
MH  - Parents
MH  - Public Health
MH  - Reproducibility of Results
EDAT- 2011/01/01 06:00
MHDA- 2011/02/25 06:00
CRDT- 2011/01/01 06:00
PHST- 2011/01/01 06:00 [entrez]
PHST- 2011/01/01 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
PST - ppublish
SO  - Rev Derecho Genoma Hum. 2010 Jan-Jun;(32):221-41.


PMID- 21191830
OWN - NLM
STAT- MEDLINE
DCOM- 20110513
LR  - 20211020
IS  - 1673-7458 (Electronic)
IS  - 1673-7342 (Linking)
VI  - 4
IP  - 3
DP  - 2010 Sep
TI  - Current situation and development of prenatal diagnosis in China.
PG  - 271-4
LID - 10.1007/s11684-010-0100-z [doi]
AB  - Prenatal screening and diagnosis are major methods for control of birth defects, 
      which is a very important problem in China. Here, we review current situation and
      development of prenatal screening and diagnosis in mainland China, including
      prenatal screening and prenatal diagnosis of fetal chromosome abnormalities,
      non-invasive prenatal diagnostic techniques and prenatal diagnosis of monogenic
      diseases, polygenic disease and congenital metabolic diseases. We also discuss
      epidemiology of birth defects and genetic diseases in China and related ethical
      issues of prenatal diagnosis.
FAU - Bian, Xu-Ming
AU  - Bian XM
AD  - Department of Obstetrics and Gynecology, Peking Union Medical College Hospital,
      Beijing, 100730, China. xmbian@vip.sohu.net
FAU - Guo, Qi
AU  - Guo Q
FAU - Qi, Qing-Wei
AU  - Qi QW
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100810
PL  - China
TA  - Front Med China
JT  - Frontiers of medicine in China
JID - 101392716
SB  - IM
MH  - Amniocentesis/statistics & numerical data
MH  - China/epidemiology
MH  - Chromosome Aberrations
MH  - Congenital Abnormalities/diagnosis/embryology
MH  - Female
MH  - Fetal Diseases/diagnosis
MH  - Genetic Diseases, Inborn/diagnosis/embryology
MH  - Humans
MH  - Pregnancy
MH  - Prenatal Diagnosis/ethics/*statistics & numerical data
MH  - Ultrasonography, Prenatal/statistics & numerical data
EDAT- 2010/12/31 06:00
MHDA- 2011/05/14 06:00
CRDT- 2010/12/31 06:00
PHST- 2010/05/10 00:00 [received]
PHST- 2010/05/17 00:00 [accepted]
PHST- 2010/12/31 06:00 [entrez]
PHST- 2010/12/31 06:00 [pubmed]
PHST- 2011/05/14 06:00 [medline]
AID - 10.1007/s11684-010-0100-z [doi]
PST - ppublish
SO  - Front Med China. 2010 Sep;4(3):271-4. doi: 10.1007/s11684-010-0100-z. Epub 2010
      Aug 10.


PMID- 21191652
OWN - NLM
STAT- MEDLINE
DCOM- 20110519
LR  - 20211020
IS  - 1573-6903 (Electronic)
IS  - 0364-3190 (Linking)
VI  - 36
IP  - 3
DP  - 2011 Mar
TI  - Rostrocaudal dynamics of CSF biomarkers.
PG  - 528-32
LID - 10.1007/s11064-010-0374-1 [doi]
AB  - The rostrocaudal gradient (RCG) of markers present in cerebrospinal fluid (CSF)
      has not been studied adequately due to lack of appropriate control populations
      and ethical restrictions. The aim of this study is to understand the rostrocaudal
      gradient of CSF biomarkers. We contacted a study comparing CSF levels of seven
      biomarkers from cisternal (rostral) and lumbar (caudal) CSF obtained from
      patients with trigeminal neuralgia and tension-type headache. The RCGs of
      CSF/serum albumin ratio, 8-isoprostane. GFAP, total tau and beta amyloid protein 
      were higher than one. The RCGs of lactate, VEGF and the heavy chain of
      neurofilament protein were lower than one. The study provides new values for
      several commonly examined markers of cisternal CSF. Knowledge of the RCG gradient
      of different CSF markers is important in interpreting studies reporting
      ventricular CSF values.
FAU - Tarnaris, Andrew
AU  - Tarnaris A
AD  - The Victor Horsley Department of Neurosurgery, National Hospital for Neurology
      and Neurosurgery, Box 32, Queen Square, London, WC, 1N 3BG, UK.
      andrewtarnaris@gmail.com
FAU - Toma, Ahmed K
AU  - Toma AK
FAU - Chapman, Miles D
AU  - Chapman MD
FAU - Petzold, Axel
AU  - Petzold A
FAU - Keir, Geoff
AU  - Keir G
FAU - Kitchen, Neil D
AU  - Kitchen ND
FAU - Watkins, Laurence D
AU  - Watkins LD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101230
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
RN  - 0 (Biomarkers)
SB  - IM
EIN - Neurochem Res. 2012 Jan;37(1):232
MH  - Adult
MH  - Aged
MH  - Biomarkers/*cerebrospinal fluid
MH  - Brain/*anatomy & histology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Reference Standards
MH  - Spinal Puncture
MH  - Tension-Type Headache/cerebrospinal fluid
MH  - Trigeminal Neuralgia/cerebrospinal fluid
EDAT- 2010/12/31 06:00
MHDA- 2011/05/20 06:00
CRDT- 2010/12/31 06:00
PHST- 2010/12/15 00:00 [accepted]
PHST- 2010/12/31 06:00 [entrez]
PHST- 2010/12/31 06:00 [pubmed]
PHST- 2011/05/20 06:00 [medline]
AID - 10.1007/s11064-010-0374-1 [doi]
PST - ppublish
SO  - Neurochem Res. 2011 Mar;36(3):528-32. doi: 10.1007/s11064-010-0374-1. Epub 2010
      Dec 30.


PMID- 21189731
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20161021
IS  - 1134-7198 (Print)
IS  - 1134-7198 (Linking)
IP  - 32
DP  - 2010 Jan-Jun
TI  - Synthetic biology & human health: some initial thoughts on the ethical questions 
      and how we ought to approach them.
PG  - 119-41
AB  - The emerging field of synthetic biology aims to move beyond our current state of 
      being able to read and manipulate genetic code to being able to write it. Drawing
      on the other disciplines such as engineering it will allow scientists to create
      new artificial biological systems as well as modify and redesign systems which
      already exist in nature. This is likely to result in a range of new and
      innovative applications. This essay has three aims. First, it provides a brief
      introduction to synthetic biology, explains what it is, some of the ways in which
      it has been defined and some of its possible future applications. Second, the
      essay considers some of the ethical questions which synthetic biology may raise. 
      Finally, the essay reflects on how we ought to answer these sorts of questions
      and suggests a more reflective, philosophical approach.
FAU - ter Meulen, Ruud
AU  - ter Meulen R
AD  - University of Bristol, Centre for Ethics in Medicine, United Kingdom.
FAU - Calladine, Alex
AU  - Calladine A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Spain
TA  - Rev Derecho Genoma Hum
JT  - Revista de derecho y genoma humano = Law and the human genome review
JID - 101558644
SB  - IM
MH  - *Health
MH  - Humans
MH  - Synthetic Biology/*ethics
EDAT- 2010/12/31 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/12/31 06:00
PHST- 2010/12/31 06:00 [entrez]
PHST- 2010/12/31 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
PST - ppublish
SO  - Rev Derecho Genoma Hum. 2010 Jan-Jun;(32):119-41.


PMID- 21189729
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20161021
IS  - 1134-7198 (Print)
IS  - 1134-7198 (Linking)
IP  - 32
DP  - 2010 Jan-Jun
TI  - Research on human cells reprogramming in Andalusia (Spain): Quo vadis Europe?
PG  - 25-45
AB  - Andalusia has a special situation within Spain, among the group of countries that
      lead biomedical research on embryonic cell reprogramming at a global level,
      research which seems to have overcome the moral and ethical controversy
      surrounding other research techniques involving the creation-destruction of human
      embryos. Nevertheless, as there is no common European conception of human life,
      some ethical problems could emerge in the near future when it comes to patenting 
      the results of these cell-reprogramming techniques at a European level.
FAU - Garcia San Jose, Daniel
AU  - Garcia San Jose D
AD  - University of Seville, Seville, Spain. dagarcia@us.es
LA  - eng
PT  - Journal Article
PL  - Spain
TA  - Rev Derecho Genoma Hum
JT  - Revista de derecho y genoma humano = Law and the human genome review
JID - 101558644
SB  - IM
MH  - Biomedical Research/*trends
MH  - *Cellular Reprogramming
MH  - Cloning, Organism
MH  - Embryonic Stem Cells
MH  - Europe
MH  - Humans
MH  - Spain
EDAT- 2010/12/31 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/12/31 06:00
PHST- 2010/12/31 06:00 [entrez]
PHST- 2010/12/31 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
PST - ppublish
SO  - Rev Derecho Genoma Hum. 2010 Jan-Jun;(32):25-45.


PMID- 21188886
OWN - HMD
STAT- MEDLINE
DCOM- 20110331
LR  - 20191027
IS  - 0007-7720 (Print)
IS  - 0007-7720 (Linking)
VI  - 40
IP  - 3
DP  - 2010
TI  - Between the town and the mountain: abortion and the politics of life in Edith
      Wharton's "Summer".
PG  - 351-72
AB  - In the early twentieth century, American laws focused on women's reproductive
      capacities and were coalescing into the ethical and moral frameworks that subtend
      American reproductive politics today. Edith Wharton published her 1917 novel,
      Summer, at a time when anti-abortion sentiment was widespread in American
      culture. Through a reading of Summer, the article provides a theoretical and
      historical framework for understanding this new American obsession with the
      judicial regulation of women's reproductive options. In particular, I situate the
      novel's presentation of abortion within the tension between the carefully defined
      laws of North Dormer, the town in which the majority of the story takes place,
      and the lawlessness of the Mountain, a place that looms throughout the story as
      the protagonist's birthplace and a location of utmost abjection. The novel's
      profound insight is that power does not function unilaterally and individually
      but through and on the population. Furthermore, Wharton leaps ahead by
      recognizing that life is not simply that which lives but that which is recognized
      and embraced by the law. This realization, one that Wharton must have come to
      terms with through her painful work with World War I refugees, shapes Charity's
      character and her understanding not only of how reproduction is regulated but
      also of how living within this regulation and control generates the norm and
      offers the only possibility for a liveable and legible life.
FAU - Weingarten, Karen
AU  - Weingarten K
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - Canada
TA  - Can Rev Am Stud
JT  - Canadian review of American studies
JID - 100967066
MH  - *Abortion, Induced/economics/education/history/legislation &
      jurisprudence/psychology
MH  - History, 20th Century
MH  - *Jurisprudence/history
MH  - *Literature/history
MH  - *Politics
MH  - *Reproductive Rights/economics/education/history/legislation &
      jurisprudence/psychology
MH  - Social Conditions/economics/history/legislation & jurisprudence
MH  - United States/ethnology
MH  - *Women's Health/ethnology/history
MH  - Women's Rights/economics/education/history/legislation & jurisprudence
EDAT- 2010/12/30 06:00
MHDA- 2011/04/01 06:00
CRDT- 2010/12/30 06:00
PHST- 2010/12/30 06:00 [entrez]
PHST- 2010/12/30 06:00 [pubmed]
PHST- 2011/04/01 06:00 [medline]
AID - 10.3138/cras.40.3.351 [doi]
PST - ppublish
SO  - Can Rev Am Stud. 2010;40(3):351-72. doi: 10.3138/cras.40.3.351.


PMID- 21188863
OWN - NLM
STAT- MEDLINE
DCOM- 20110131
LR  - 20220318
IS  - 1592-5986 (Print)
IS  - 1592-5986 (Linking)
VI  - 29
IP  - 3
DP  - 2010 Jul-Sep
TI  - [Reflective writing in nursing education: background, experiences and methods].
PG  - 140-52
AB  - INTRODUCTION: In the nursing field, writing one's own educational/professional
      experience has been utilized for a long time, to develop reflection and therefore
      learning. Reflective writing has been fostered to sustain the development of
      nurses' clinical, relational and ethical competence, and to promote self
      knowledge. AIM: To de scribe reflective writing experiences published in the
      literature, focussing on the educational contexts and the writing strategies used
      in the nursing field. Method. Narrative analysis of the international literature,
      based on the MedLine and Cinahl data sources. RESULTS: Reflective writing is used
      in undergraduate, post-graduate and continuing nursing education, to develop
      clinical learning or a professional and/or personal growth. In the former, short 
      written assignments (also starting from scenarios) are given, while diaries and
      journals, with prompts focalizing on specific aspects of the experience, support 
      a more global growth of the student/professional. These prompts are useful with
      individuals not used to write. Critical incidents or meaningful episodes from the
      clinical practice are also used. Many papers underline the importance of sharing 
      writings with peers and/or a teacher/facilitator. CONCLUSIONS: Nursing
      students/professionals can be effectively supported by reflective writing in
      their experiential learning. However, their attitude to reflective writing should
      be considered with care and a feedback by peers and/or a facilitator must be
      provided. Since giving feedback requires adequate human resources, the
      implementation of writing activities in the nursing training should be carefully 
      evaluated.
FAU - Montagna, Licia
AU  - Montagna L
AD  - Universita degli Studi di Milano.
FAU - Benaglio, Carla
AU  - Benaglio C
FAU - Zannini, Lucia
AU  - Zannini L
LA  - ita
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - La scrittura riflessiva nella formazione infermieristica: background, esperienze 
      e metodi.
PL  - Italy
TA  - Assist Inferm Ric
JT  - Assistenza infermieristica e ricerca : AIR
JID - 100901776
MH  - Education, Nursing/*methods
MH  - *Writing
EDAT- 2010/12/30 06:00
MHDA- 2011/02/01 06:00
CRDT- 2010/12/30 06:00
PHST- 2010/12/30 06:00 [entrez]
PHST- 2010/12/30 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
PST - ppublish
SO  - Assist Inferm Ric. 2010 Jul-Sep;29(3):140-52.


PMID- 21188791
OWN - NLM
STAT- MEDLINE
DCOM- 20110301
LR  - 20101223
IS  - 1259-4792 (Print)
IS  - 1259-4792 (Linking)
IP  - 257
DP  - 2010 Nov-Dec
TI  - [Communication and ethics in the hospital].
PG  - 6
FAU - Barsky, Emmanuelle
AU  - Barsky E
LA  - fre
PT  - Journal Article
TT  - Communication et ethique a l'hopital.
PL  - France
TA  - Soins Pediatr Pueric
JT  - Soins. Pediatrie, puericulture
JID - 9604503
MH  - *Ethics, Institutional
MH  - Humans
MH  - *Interprofessional Relations
MH  - Personnel Administration, Hospital/*standards
EDAT- 2010/12/29 06:00
MHDA- 2011/03/02 06:00
CRDT- 2010/12/29 06:00
PHST- 2010/12/29 06:00 [entrez]
PHST- 2010/12/29 06:00 [pubmed]
PHST- 2011/03/02 06:00 [medline]
PST - ppublish
SO  - Soins Pediatr Pueric. 2010 Nov-Dec;(257):6.


PMID- 21188543
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20211020
IS  - 1863-4362 (Electronic)
IS  - 0021-1265 (Linking)
VI  - 180
IP  - 2
DP  - 2011 Jun
TI  - A study of needle stick injuries among non-consultant hospital doctors in
      Ireland.
PG  - 445-9
LID - 10.1007/s11845-010-0667-z [doi]
AB  - INTRODUCTION: NCHDs are exposed to a great number of blood-borne infections.
      Needle stick injuries are possibly the main route of acquiring such infections
      from a non-consultant hospital doctors (NCHDs) perspective. This study examines
      NCHDs experiences surrounding needle stick injuries. METHODS: A cross-sectional
      self-administered anonymous questionnaire survey was conducted on 185 NCHDs
      working in a clinical setting among seven teaching hospitals in Ireland. Implied 
      consent was obtained. The data was analysed using Excel spreadsheets. Ethical
      approval was received. RESULTS: A response rate of 85.4% (158/185) was achieved. 
      Findings of the study are shown in the manuscript table. CONCLUSIONS: A needle
      stick injury (NI) history is greater among surgical NCHDs than medical NCHDs. The
      level of disposable glove usage is worryingly poor. Training in sharps handling
      and dealing with a NI needs to be addressed. HIV is the blood-borne infection
      most fear of being contracting as a consequence of a NI.
FAU - O'Connor, M B
AU  - O'Connor MB
AD  - Department of Medicine, South Infirmary, Victoria University Hospital, Old
      Blackrock Road, Cork, Ireland. mortimeroconnor@gmail.com
FAU - Hannon, M J
AU  - Hannon MJ
FAU - Cagney, D
AU  - Cagney D
FAU - Harrington, U
AU  - Harrington U
FAU - O'Brien, F
AU  - O'Brien F
FAU - Hardiman, N
AU  - Hardiman N
FAU - O'Connor, R
AU  - O'Connor R
FAU - Courtney, K
AU  - Courtney K
FAU - O'Connor, C
AU  - O'Connor C
LA  - eng
PT  - Journal Article
DEP - 20101229
PL  - Ireland
TA  - Ir J Med Sci
JT  - Irish journal of medical science
JID - 7806864
SB  - IM
MH  - *Accidents, Occupational
MH  - Adult
MH  - Cross-Sectional Studies
MH  - Female
MH  - Gloves, Surgical/statistics & numerical data
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Ireland/epidemiology
MH  - Male
MH  - *Medical Staff, Hospital
MH  - Middle Aged
MH  - Needlestick Injuries/*epidemiology/prevention & control
MH  - Risk Factors
MH  - Young Adult
EDAT- 2010/12/29 06:00
MHDA- 2011/10/25 06:00
CRDT- 2010/12/29 06:00
PHST- 2007/09/06 00:00 [received]
PHST- 2010/12/15 00:00 [accepted]
PHST- 2010/12/29 06:00 [entrez]
PHST- 2010/12/29 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
AID - 10.1007/s11845-010-0667-z [doi]
PST - ppublish
SO  - Ir J Med Sci. 2011 Jun;180(2):445-9. doi: 10.1007/s11845-010-0667-z. Epub 2010
      Dec 29.


PMID- 21188023
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 0974-9241 (Electronic)
IS  - 0974-7753 (Linking)
VI  - 2
IP  - 1
DP  - 2010 Jan
TI  - Ethics in trichology.
PG  - 40-1
LID - 10.4103/0974-7753.66912 [doi]
AB  - Today, trichology as a science is offered by reputed institutes worldwide with a 
      planned curriculum of theory and clinical exposure. Non-medical trichologists,
      with rare exceptions, continue to lure the public with unscientific methods. A
      qualified dermatologist equipped with knowledge of hair biology is undoubtedly
      the most competent to deal with hair problems. We are all indisputably governed
      by a basic code of medical ethics as we are doctors first and last. Hence, a
      dermatologist/trichologist cannot have another set of ethics. Having said that,
      we cannot discount the fact that there are special clinical situations where
      guidelines already exist or need to be established with compliance to the base
      code of ethics.
FAU - Padmanabhan, Parvathi
AU  - Padmanabhan P
AD  - Dermatologists, Chennai, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Int J Trichology
JT  - International journal of trichology
JID - 101534370
PMC - PMC3002410
OTO - NOTNLM
OT  - Ethics
OT  - dermatology
OT  - trichology
EDAT- 2010/12/29 06:00
MHDA- 2010/12/29 06:01
CRDT- 2010/12/29 06:00
PHST- 2010/12/29 06:00 [entrez]
PHST- 2010/12/29 06:00 [pubmed]
PHST- 2010/12/29 06:01 [medline]
AID - 10.4103/0974-7753.66912 [doi]
PST - ppublish
SO  - Int J Trichology. 2010 Jan;2(1):40-1. doi: 10.4103/0974-7753.66912.


PMID- 21187860
OWN - NLM
STAT- MEDLINE
DCOM- 20110830
LR  - 20211020
IS  - 1748-7838 (Electronic)
IS  - 1001-0602 (Linking)
VI  - 21
IP  - 5
DP  - 2011 May
TI  - Mouse cloning and somatic cell reprogramming using electrofused blastomeres.
PG  - 770-8
LID - 10.1038/cr.2010.180 [doi]
AB  - Mouse cloning from fertilized eggs can assist development of approaches for the
      production of "genetically tailored" human embryonic stem (ES) cell lines that
      are not constrained by the limitations of oocyte availability. However, to date
      only zygotes have been successfully used as recipients of nuclei from terminally 
      differentiated somatic cell donors leading to ES cell lines. In fertility
      clinics, embryos of advanced embryonic stages are usually stored for future use, 
      but their ability to support the derivation of ES cell lines via somatic nuclear 
      transfer has not yet been proved. Here, we report that two-cell stage
      electrofused mouse embryos, arrested in mitosis, can support developmental
      reprogramming of nuclei from donor cells ranging from blastomeres to somatic
      cells. Live, full-term cloned pups from embryonic donors, as well as pluripotent 
      ES cell lines from embryonic or somatic donors, were successfully generated from 
      these reconstructed embryos. Advanced stage pre-implantation embryos were unable 
      to develop normally to term after electrofusion and transfer of a somatic cell
      nucleus, indicating that discarded pre-implantation human embryos could be an
      important resource for research that minimizes the ethical concerns for human
      therapeutic cloning. Our approach provides an attractive and practical
      alternative to therapeutic cloning using donated oocytes for the generation of
      patient-specific human ES cell lines.
FAU - Riaz, Amjad
AU  - Riaz A
AD  - State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese
      Academy of Sciences, 1st Beichen West Road, Beijing 100101, China.
FAU - Zhao, Xiaoyang
AU  - Zhao X
FAU - Dai, Xiangpeng
AU  - Dai X
FAU - Li, Wei
AU  - Li W
FAU - Liu, Lei
AU  - Liu L
FAU - Wan, Haifeng
AU  - Wan H
FAU - Yu, Yang
AU  - Yu Y
FAU - Wang, Liu
AU  - Wang L
FAU - Zhou, Qi
AU  - Zhou Q
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101228
PL  - England
TA  - Cell Res
JT  - Cell research
JID - 9425763
RN  - 0 (Octamer Transcription Factor-3)
RN  - 0 (Pou5f1 protein, mouse)
SB  - IM
MH  - Animals
MH  - Blastomeres/*cytology/metabolism
MH  - Cell Fusion/*methods
MH  - Cell Line
MH  - *Cellular Reprogramming
MH  - Chromosomes, Mammalian/metabolism
MH  - *Cloning, Organism
MH  - Cytoplasm/metabolism
MH  - Electroporation/*methods
MH  - Embryo, Mammalian/cytology
MH  - Embryonic Stem Cells/cytology/metabolism
MH  - Fibroblasts/cytology
MH  - Humans
MH  - Mice
MH  - Mitosis
MH  - Octamer Transcription Factor-3/metabolism
MH  - Pluripotent Stem Cells/cytology/metabolism
MH  - Tetraploidy
PMC - PMC3203665
EDAT- 2010/12/29 06:00
MHDA- 2011/08/31 06:00
CRDT- 2010/12/29 06:00
PHST- 2010/12/29 06:00 [entrez]
PHST- 2010/12/29 06:00 [pubmed]
PHST- 2011/08/31 06:00 [medline]
AID - cr2010180 [pii]
AID - 10.1038/cr.2010.180 [doi]
PST - ppublish
SO  - Cell Res. 2011 May;21(5):770-8. doi: 10.1038/cr.2010.180. Epub 2010 Dec 28.


PMID- 21187700
OWN - NLM
STAT- MEDLINE
DCOM- 20110510
LR  - 20191027
IS  - 1880-1293 (Electronic)
IS  - 0022-9717 (Linking)
VI  - 59
IP  - 4
DP  - 2010
TI  - Learning experiences and assessment in the first 2 years of the medical course at
      King's College London School of Medicine.
PG  - 140-5
AB  - The medical curriculum at King's College London School of Medicine is a 5 year
      course; an extended program (6 years) and a graduate entry program (4 years) are 
      also available. The first 2 years of the curriculum comprise phases 1 and 2. The 
      curriculum consists of core material that is common to all students and
      student-selected components (students undertake three such components in the
      first 2 years). Phase 1 lasts 12 weeks and students learn the principles of
      tissue and organ structure and function. They are also introduced to the practice
      of medicine (concepts of health, communication, ethics, inter-professional
      education and medicine in the community). Phase 2 consists of 36 weekly clinical 
      scenarios that place basic medical science in a clinical context. Phase 2 covers 
      cardiovascular, respiratory, gastrointestinal, renal and musculoskeletal systems;
      nutrition; endocrinology; head and neck anatomy; neuroscience; genetics; and
      infections. Teaching continues in pri! mary care and in the hospitals and
      includes basic and advanced life support. Learning experiences include lectures, 
      tutorials, practical classes, dissection and prosection, communication skills,
      e-learning, student-led sessions and primary care and hospital visits. Assessment
      consists of in-course assessment (e.g., presentations, tests and essays) and
      end-of-year examinations which consist of written papers and an objective
      structured clinical examination at the end of year 2. The main strengths of the
      program include the scenario format of learning and the practice of medicine
      early on. The difficulties arise mainly from the large numbers of students (420
      per year).
FAU - Papachristodoulou, Despo
AU  - Papachristodoulou D
AD  - Department of Biochemistry, King's College London School of Medicine, London, UK.
      despo.papachristodoulou@kcl.ac.uk
LA  - eng
PT  - Lecture
PL  - Japan
TA  - Keio J Med
JT  - The Keio journal of medicine
JID - 0376354
SB  - IM
MH  - *Curriculum
MH  - *Education, Medical, Undergraduate
MH  - London
MH  - Medicine
MH  - *Problem-Based Learning
MH  - Schools/organization & administration
MH  - *Students, Medical/psychology
MH  - Teaching
EDAT- 2010/12/29 06:00
MHDA- 2011/05/11 06:00
CRDT- 2010/12/29 06:00
PHST- 2010/12/29 06:00 [entrez]
PHST- 2010/12/29 06:00 [pubmed]
PHST- 2011/05/11 06:00 [medline]
AID - 10.2302/kjm.59.140 [doi]
PST - ppublish
SO  - Keio J Med. 2010;59(4):140-5. doi: 10.2302/kjm.59.140.


PMID- 21187281
OWN - NLM
STAT- MEDLINE
DCOM- 20110607
LR  - 20191210
IS  - 1468-2834 (Electronic)
IS  - 0002-0729 (Linking)
VI  - 40
IP  - 2
DP  - 2011 Mar
TI  - Use of NSAIDs for osteoarthritis amongst older-aged primary care patients:
      engagement with information and perceptions of risk.
PG  - 254-9
LID - 10.1093/ageing/afq160 [doi]
AB  - BACKGROUND: non-steroidal anti-inflammatory drugs (NSAIDs) are used commonly to
      treat osteoarthritis in older patients. OBJECTIVE: to explore the understandings 
      of risk that older-aged primary care patients have in the context of the use of
      oral NSAIDs to treat osteoarthritis. METHOD: semi-structured interviews were
      conducted with 15 patients who were recruited from four general practices located
      in Sydney, Australia. Patients were aged at least 65 years and were currently
      taking, or in the past 2 years had taken, an NSAID for osteoarthritis. Emergent
      themes were identified from the transcripts and were compared within and across
      transcripts to develop more abstract concepts. RESULTS: patients demonstrated
      three key 'modes of disengagement' from medication-specific risk information,
      each of which could also be a mode of modulating a sense of danger and each of
      which would demand a unique clinical response. These were: 'transference of
      responsibility'-transferring the responsibility to their GP, 'general versus
      specific risk'-considering the risk of taking medicine in general as opposed to
      the specific risk of taking an NSAID, and 'personal immunity'-some patients with 
      a long history of NSAID use without apparent toxicity believed they were,
      therefore, not at risk of future adverse effects, while a few patients believed
      they were immune to adverse effects of drugs in general. CONCLUSION: there is a
      need for greater recognition of these 'modes of disengagement'/'hazard
      modulation' in order to attain a clinical response leading to safer, more
      effective and more ethical use of medicines.
FAU - Milder, Tamara Y
AU  - Milder TY
AD  - Clinical Pharmacology and Toxicology, University of New South Wales, Sydney, New 
      South Wales, Australia.
FAU - Williams, Kenneth M
AU  - Williams KM
FAU - Ritchie, Jan E
AU  - Ritchie JE
FAU - Lipworth, Wendy L
AU  - Lipworth WL
FAU - Day, Richard O
AU  - Day RO
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101226
PL  - England
TA  - Age Ageing
JT  - Age and ageing
JID - 0375655
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
SB  - IM
MH  - Administration, Oral
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - *Aging
MH  - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/*adverse effects
MH  - Awareness
MH  - Comprehension
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - New South Wales
MH  - Osteoarthritis/*drug therapy
MH  - *Patient Education as Topic
MH  - *Perception
MH  - *Primary Health Care
MH  - Qualitative Research
MH  - Risk Assessment
MH  - Transference, Psychology
EDAT- 2010/12/29 06:00
MHDA- 2011/06/08 06:00
CRDT- 2010/12/29 06:00
PHST- 2010/12/29 06:00 [entrez]
PHST- 2010/12/29 06:00 [pubmed]
PHST- 2011/06/08 06:00 [medline]
AID - afq160 [pii]
AID - 10.1093/ageing/afq160 [doi]
PST - ppublish
SO  - Age Ageing. 2011 Mar;40(2):254-9. doi: 10.1093/ageing/afq160. Epub 2010 Dec 26.


PMID- 21186208
OWN - NLM
STAT- MEDLINE
DCOM- 20110523
LR  - 20220330
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 4
DP  - 2011 Apr
TI  - Retractions in the scientific literature: is the incidence of research fraud
      increasing?
PG  - 249-53
LID - 10.1136/jme.2010.040923 [doi]
AB  - BACKGROUND: Scientific papers are retracted for many reasons including fraud
      (data fabrication or falsification) or error (plagiarism, scientific mistake,
      ethical problems). Growing attention to fraud in the lay press suggests that the 
      incidence of fraud is increasing. METHODS: The reasons for retracting 742 English
      language research papers retracted from the PubMed database between 2000 and 2010
      were evaluated. Reasons for retraction were initially dichotomised as fraud or
      error and then analysed to determine specific reasons for retraction. RESULTS:
      Error was more common than fraud (73.5% of papers were retracted for error (or an
      undisclosed reason) vs 26.6% retracted for fraud). Eight reasons for retraction
      were identified; the most common reason was scientific mistake in 234 papers
      (31.5%), but 134 papers (18.1%) were retracted for ambiguous reasons. Fabrication
      (including data plagiarism) was more common than text plagiarism. Total papers
      retracted per year have increased sharply over the decade (r=0.96; p<0.001), as
      have retractions specifically for fraud (r=0.89; p<0.001). Journals now reach
      farther back in time to retract, both for fraud (r=0.87; p<0.001) and for
      scientific mistakes (r=0.95; p<0.001). Journals often fail to alert the naive
      reader; 31.8% of retracted papers were not noted as retracted in any way.
      CONCLUSIONS: Levels of misconduct appear to be higher than in the past. This may 
      reflect either a real increase in the incidence of fraud or a greater effort on
      the part of journals to police the literature. However, research bias is rarely
      cited as a reason for retraction.
FAU - Steen, R Grant
AU  - Steen RG
AD  - Medical Communications Consultants, LLC 103 Van Doren Place, Chapel Hill, NC
      27517, USA. g_steen_medicc@yahoo.com
LA  - eng
PT  - Journal Article
DEP - 20101224
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Authorship/standards
MH  - Biomedical Research/ethics/*standards
MH  - Periodicals as Topic/ethics/standards/*statistics & numerical data
MH  - *Plagiarism
MH  - PubMed/statistics & numerical data
MH  - *Retraction of Publication as Topic
MH  - Scientific Misconduct/ethics/*statistics & numerical data
EDAT- 2010/12/28 06:00
MHDA- 2011/05/24 06:00
CRDT- 2010/12/28 06:00
PHST- 2010/12/28 06:00 [entrez]
PHST- 2010/12/28 06:00 [pubmed]
PHST- 2011/05/24 06:00 [medline]
AID - jme.2010.040923 [pii]
AID - 10.1136/jme.2010.040923 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Apr;37(4):249-53. doi: 10.1136/jme.2010.040923. Epub 2010 Dec 
      24.


PMID- 21186207
OWN - NLM
STAT- MEDLINE
DCOM- 20110523
LR  - 20211020
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 4
DP  - 2011 Apr
TI  - The challenge of defining standards of prevention in HIV prevention trials.
PG  - 244-8
LID - 10.1136/jme.2010.037176 [doi]
AB  - As new HIV prevention tools are developed, researchers face a number of ethical
      and logistic questions about how and when to include novel HIV prevention
      strategies and tools in the standard prevention package of ongoing and future HIV
      prevention trials. Current Joint United Nations Programme on HIV/AIDS
      (UNAIDS)/World Health Organization (WHO) guidance recommends that participants in
      prevention trials receive 'access to all state of the art HIV risk reduction
      methods', and that decisions about adding new tools to the prevention package be 
      made in consultation with 'all relevant stakeholders'. The guidance, however,
      leaves open questions of both process and implementation. In March 2009, the
      Global Campaign for Microbicides, UNAIDS and the Centers for Disease Control and 
      Prevention convened a consultation to develop practical answers to these
      questions. Fifty-nine diverse participants, including researchers, ethicists,
      advocates and policymakers, worked to develop consensus criteria on when to
      include new HIV prevention tools in future trials. Participants developed a set
      of questions to guide decision-making, including: whether the method has been
      recommended by international bodies or adopted at a national level; the size of
      the effect and weight of the evidence; relevance to the trial population; whether
      the tool has been approved or introduced in the trial country; whether adding the
      tool might lead to trial futility; outstanding safety issues and status of the
      trial. Further work is needed to develop, implement and evaluate approaches to
      facilitate meaningful stakeholder participation in this deliberative process.
FAU - Philpott, Sean
AU  - Philpott S
AD  - The Bioethics Program, Union Graduate College, 80 Nott Terrace, Schenectady, NY
      12308, USA. philpots@mail.uniongraduatecollege.edu
FAU - Heise, Lori
AU  - Heise L
FAU - McGrory, Elizabeth
AU  - McGrory E
FAU - Paxton, Lynn
AU  - Paxton L
FAU - Hankins, Catherine
AU  - Hankins C
CN  - participants in the 2009 GCM/CDC/UNAIDS Consultation on Standards of Prevention
      in HIV Prevention Trials
LA  - eng
GR  - G0100137/MRC_/Medical Research Council/United Kingdom
GR  - MC_U122861400/MRC_/Medical Research Council/United Kingdom
GR  - MC_U950097145/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20101224
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
RN  - 0 (Anti-Retroviral Agents)
SB  - IM
MH  - Anti-Retroviral Agents/*therapeutic use
MH  - Biomedical Research/ethics/methods/standards
MH  - Clinical Trials as Topic/ethics/methods/*standards
MH  - HIV Infections/*prevention & control
MH  - Human Experimentation/ethics/standards
MH  - Humans
MH  - International Cooperation
MH  - Risk Assessment
MH  - Risk Reduction Behavior
MH  - United Nations
MH  - World Health Organization
IR  - Alexander L
FIR - Alexander, Lorraine
IR  - Apuuli DK
FIR - Apuuli, David Kihumuro
IR  - Baeten J
FIR - Baeten, Jared
IR  - Birx D
FIR - Birx, Deborah
IR  - de Bruyn G
FIR - de Bruyn, Guy
IR  - Bukusi E
FIR - Bukusi, Elizabeth
IR  - Burns D
FIR - Burns, David
IR  - Calazans G
FIR - Calazans, Gabriela
IR  - Campbell J
FIR - Campbell, James
IR  - Caswell G
FIR - Caswell, Georgina
IR  - Coutinho A
FIR - Coutinho, Alex
IR  - Dawson L
FIR - Dawson, Liza
IR  - Dhai A
FIR - Dhai, Amaboo
IR  - Dube S
FIR - Dube, Samukeliso
IR  - Ecuru J
FIR - Ecuru, Julius
IR  - Essack Z
FIR - Essack, Zaynab
IR  - Farley T
FIR - Farley, Timothy
IR  - Gafos M
FIR - Gafos, Mitzy
IR  - Hankins C
FIR - Hankins, Catherine
IR  - Heise L
FIR - Heise, Lori
IR  - Irungu P
FIR - Irungu, Pauline
IR  - Kaleebu P
FIR - Kaleebu, Pontiano
IR  - Kamali A
FIR - Kamali, Anatoli
IR  - Kestelyn E
FIR - Kestelyn, Evelyne
IR  - Kublin J
FIR - Kublin, James
IR  - Lohse N
FIR - Lohse, Nicolai
IR  - Lutalo T
FIR - Lutalo, Tom
IR  - Macklin R
FIR - Macklin, Ruth
IR  - Masse B
FIR - Masse, Benoit
IR  - Mauney C
FIR - Mauney, Chris
IR  - McCormack S
FIR - McCormack, Sheena
IR  - McGrory E
FIR - McGrory, Elizabeth
IR  - Miller L
FIR - Miller, Lori
IR  - Mfutso-Bengo J
FIR - Mfutso-Bengo, Joseph
IR  - Misra R
FIR - Misra, Rajender
IR  - Muganwa M
FIR - Muganwa, Margaret
IR  - Ndase P
FIR - Ndase, Patrick
IR  - Nel A
FIR - Nel, Annalene
IR  - Nielsen L
FIR - Nielsen, Leslie
IR  - Nkala B
FIR - Nkala, Busisiwe
IR  - O'Reilly K
FIR - O'Reilly, Kevin
IR  - Okware S
FIR - Okware, Sam
IR  - Paicheler G
FIR - Paicheler, Genevieve
IR  - Paxton L
FIR - Paxton, Lynn
IR  - Philpott S
FIR - Philpott, Sean
IR  - Rees H
FIR - Rees, Helen
IR  - Rerks-Ngarm S
FIR - Rerks-Ngarm, Supachai
IR  - Ridzon R
FIR - Ridzon, Renee
IR  - Rosenberg Z
FIR - Rosenberg, Zeda
IR  - Singh J
FIR - Singh, Jerome
IR  - Sugarman J
FIR - Sugarman, Jeremy
IR  - Taylor D
FIR - Taylor, Douglas
IR  - Tusubira E
FIR - Tusubira, Evans
IR  - Ukpong M
FIR - Ukpong, Morenike
IR  - Umulisa MM
FIR - Umulisa, Marie-Michele
IR  - Warren M
FIR - Warren, Mitchell
IR  - Slevin KW
FIR - Slevin, Katherine West
IR  - van de Wijgert J
FIR - van de Wijgert, Janneke
EDAT- 2010/12/28 06:00
MHDA- 2011/05/24 06:00
CRDT- 2010/12/28 06:00
PHST- 2010/12/28 06:00 [entrez]
PHST- 2010/12/28 06:00 [pubmed]
PHST- 2011/05/24 06:00 [medline]
AID - jme.2010.037176 [pii]
AID - 10.1136/jme.2010.037176 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Apr;37(4):244-8. doi: 10.1136/jme.2010.037176. Epub 2010 Dec
      24.


PMID- 21186206
OWN - NLM
STAT- MEDLINE
DCOM- 20110519
LR  - 20211020
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 3
DP  - 2011 Mar
TI  - Post mortem scientific sampling and the search for causes of death in intensive
      care: what information should be given and what consent should be obtained?
PG  - 132-6
LID - 10.1136/jme.2010.037739 [doi]
AB  - PURPOSE: The search for cause of death is important to improve knowledge and
      provide answers for the relatives of the deceased. Medical autopsy following
      unexplained death in hospital is one way to identify cause of death but is
      difficult to carry out routinely. Post mortem sampling (PMS) of tissues via thin 
      biopsy needle or 'mini incisions' in the skin may be a useful alternative. A
      study was undertaken to assess how this approach is perceived by intensive care
      doctors and also to evaluate how this practice is considered in ethical terms in 
      France. METHODS: A study of PMS practices immediately after death in 10 intensive
      care departments was performed. The medical director of each centre was
      interviewed by telephone and asked to describe practices in their unit and to
      outline the questions raised by this practice. RESULTS: PMS is routinely
      performed in 70% of the units which responded, without systematically obtaining
      formal consent and without precise rules for communicating results. Approaches to
      PMS differed between centres, but all physicians felt that PMS is useful for the 
      scientific information it gives and also for the information it provides for
      relatives. All physicians regret the lack of standards to structure PMS
      practices. CONCLUSION: Information from post mortem examinations is important for
      society to inform about causes of death, for doctors to improve practices and for
      decision-makers responsible for organising care. Debate persists regarding the
      balance between individual rights and community interests. It is suggested that
      an approach for identifying cause of death could easily be integrated into the
      relationship between carers and relatives, provided full transparency is
      maintained.
FAU - Rigaud, J P
AU  - Rigaud JP
AD  - Reanimation Polyvalente, Centre Hospitalier Dieppe, Avenue Pasteur, BP 219,
      Dieppe 76200, France. jrigaud@ch-dieppe.fr
FAU - Quenot, J P
AU  - Quenot JP
FAU - Borel, M
AU  - Borel M
FAU - Plu, I
AU  - Plu I
FAU - Herve, C
AU  - Herve C
FAU - Moutel, G
AU  - Moutel G
LA  - eng
PT  - Journal Article
DEP - 20101224
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Adult
MH  - Autopsy/*ethics/psychology/statistics & numerical data
MH  - *Cause of Death
MH  - *Critical Care
MH  - Family/psychology
MH  - France
MH  - *Hospital Mortality
MH  - Humans
MH  - Informed Consent/*ethics/psychology
MH  - Middle Aged
MH  - Tissue and Organ Harvesting/ethics
PMC - PMC3317884
MID - HALMS565252
OID - NLM: HALMS565252
EDAT- 2010/12/28 06:00
MHDA- 2011/05/20 06:00
CRDT- 2010/12/28 06:00
PHST- 2010/12/28 06:00 [entrez]
PHST- 2010/12/28 06:00 [pubmed]
PHST- 2011/05/20 06:00 [medline]
AID - jme.2010.037739 [pii]
AID - 10.1136/jme.2010.037739 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Mar;37(3):132-6. doi: 10.1136/jme.2010.037739. Epub 2010 Dec
      24.


PMID- 21184196
OWN - NLM
STAT- MEDLINE
DCOM- 20111205
LR  - 20211020
IS  - 1741-0444 (Electronic)
IS  - 0140-0118 (Linking)
VI  - 49
IP  - 1
DP  - 2011 Jan
TI  - Engineering and ethical constraints.
PG  - 1-2
LID - 10.1007/s11517-010-0723-x [doi]
FAU - Coronel, Ruben
AU  - Coronel R
FAU - Spaan, Jos A
AU  - Spaan JA
FAU - Voigt, Herbert F
AU  - Voigt HF
LA  - eng
PT  - Editorial
DEP - 20101224
PL  - United States
TA  - Med Biol Eng Comput
JT  - Medical & biological engineering & computing
JID - 7704869
SB  - IM
MH  - Ethics, Research
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Pain Measurement/ethics/methods
MH  - Periodicals as Topic/ethics
PMC - PMC3023854
EDAT- 2010/12/25 06:00
MHDA- 2011/12/13 00:00
CRDT- 2010/12/25 06:00
PHST- 2010/12/02 00:00 [received]
PHST- 2010/12/04 00:00 [accepted]
PHST- 2010/12/25 06:00 [entrez]
PHST- 2010/12/25 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/s11517-010-0723-x [doi]
PST - ppublish
SO  - Med Biol Eng Comput. 2011 Jan;49(1):1-2. doi: 10.1007/s11517-010-0723-x. Epub
      2010 Dec 24.


PMID- 21184139
OWN - NLM
STAT- MEDLINE
DCOM- 20110613
LR  - 20211020
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 22
IP  - 4
DP  - 2010 Dec
TI  - Ricoeur's "Petite ethique": an ethical epistemological perspective for
      clinician-bioethicists.
PG  - 311-26
LID - 10.1007/s10730-010-9146-1 [doi]
AB  - The passage from a posture of clinician to that of clinician-bioethicist poses
      significant challenges for health professionals, most notably with regards to
      theoretical or epistemological views of complex ethical impasses encountered in
      clinical settings. Apprehending these situations from the only clinical
      perspective of the nurse or the doctor, for example, can be very unproductive to 
      help solve this kind of situation and certainly poses great limits to the role of
      the clinician-bioethicist. Drawing on my own experience as a former nurse who,
      following graduate studies in bioethics has begun providing ethics consultation
      services, I argue that clinicians must undergo an epistemological transformation 
      in order to become clinician-bioethicists. A source of inspiration or framework
      for would-be clinician-bioethicists is, I suggest, the "Petite ethique" developed
      by the contemporary French philosopher Paul Ricoeur. Specifically,
      clinician-bioethicists should develop specific core ethical competencies (in line
      with the conclusions of the American Society for Bioethics and Humanities (Core
      competencies for health care ethics consultation, 1998); namely: savoir or
      knowing, savoir faire or knowing how to do, and savoir etre or knowing how to be.
FAU - Potvin, Marie-Josee
AU  - Potvin MJ
AD  - Programmes de bioethique, Departement de medecine sociale et preventive,
      Universite de Montreal, C.P. 6128, succursale centre-ville, Montreal, QC, H3C
      3J7, Canada. marie-josee.potvin@umontreal.ca
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - *Ethicists
MH  - *Ethics, Clinical
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Professional Competence
EDAT- 2010/12/25 06:00
MHDA- 2011/06/15 06:00
CRDT- 2010/12/25 06:00
PHST- 2010/12/25 06:00 [entrez]
PHST- 2010/12/25 06:00 [pubmed]
PHST- 2011/06/15 06:00 [medline]
AID - 10.1007/s10730-010-9146-1 [doi]
PST - ppublish
SO  - HEC Forum. 2010 Dec;22(4):311-26. doi: 10.1007/s10730-010-9146-1.


PMID- 21183885
OWN - NLM
STAT- MEDLINE
DCOM- 20110419
LR  - 20160210
IS  - 2329-0358 (Electronic)
IS  - 1425-9524 (Linking)
VI  - 15
IP  - 4
DP  - 2010 Oct-Dec
TI  - Heart transplantation in the elderly: why cardiac transplantation does not need
      to be limited to younger patients but can be safely performed in patients above
      65 years of age.
PG  - 110-9
AB  - Within the last forty years, heart transplantation as the ultimate option for the
      treatment of end-stage heart disease has undergone dramatic changes and advances 
      in operative techniques, postoperative care, immunosuppression, and rejection
      management which resulted in reduced morbidity and mortality. As the heart
      failure epidemic worsens and the population grows older, cardiac transplantation 
      criteria have expanded for end-stage heart disease refractory to medical
      management. Although outcomes after cardiac transplantation have improved, the
      critical organ shortage is a limitation to its efficacy. The demand-supply
      disparity for heart transplantations has led to clinical and ethical issues
      examining adequate candidacy for organ transplantation. Cardiac transplantation
      in the elderly recipient was considered a contraindication due to poor survival
      rates compared to younger recipients. Given the increase in life expectancy over 
      the last decades, single-center studies have assessed the outcome of
      transplantation among elderly recipients and comparable survival and quality of
      life have been described among older heart transplantation recipients.
      Alternatives to cardiac transplantation which have become more common, such as
      mechanical circulatory support, and further investigation of the viability of
      transplantation in the elderly may help determine the proper allocation of the
      limited organ supply.
FAU - Daneshvar, Daniel A
AU  - Daneshvar DA
AD  - Division of Cardiology, Department of Medicine, Cedars-Sinai Heart Institute,
      Cedars-Sinai Medical Center, Los Angeles, CA 90048, U.S.A.
FAU - Czer, Lawrence S C
AU  - Czer LS
FAU - Phan, Anita
AU  - Phan A
FAU - Trento, Alfredo
AU  - Trento A
FAU - Schwarz, Ernst R
AU  - Schwarz ER
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Ann Transplant
JT  - Annals of transplantation
JID - 9802544
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Heart Failure/*surgery
MH  - *Heart Transplantation/adverse effects
MH  - Humans
MH  - Treatment Outcome
EDAT- 2010/12/25 06:00
MHDA- 2011/04/20 06:00
CRDT- 2010/12/25 06:00
PHST- 2010/12/25 06:00 [entrez]
PHST- 2010/12/25 06:00 [pubmed]
PHST- 2011/04/20 06:00 [medline]
AID - 881359 [pii]
PST - ppublish
SO  - Ann Transplant. 2010 Oct-Dec;15(4):110-9.


PMID- 21182666
OWN - NLM
STAT- MEDLINE
DCOM- 20110414
LR  - 20101224
IS  - 1523-1739 (Electronic)
IS  - 0888-8892 (Linking)
VI  - 24
IP  - 5
DP  - 2010 Oct
TI  - Metaphor and the idea of a dominant conservation ethic.
PG  - 1172-3
LID - 10.1111/j.1523-1739.2010.01573.x [doi]
FAU - Martin, Laura
AU  - Martin L
LA  - eng
PT  - Comment
PT  - Letter
PL  - United States
TA  - Conserv Biol
JT  - Conservation biology : the journal of the Society for Conservation Biology
JID - 9882301
SB  - IM
CON - Conserv Biol. 2009 Apr;23(2):241-3. PMID: 19323674
MH  - *Biodiversity
MH  - Conservation of Natural Resources/economics/*methods
MH  - Consumer Advocacy/*ethics
MH  - *Ethics
EDAT- 2010/12/25 06:00
MHDA- 2011/04/16 06:00
CRDT- 2010/12/25 06:00
PHST- 2010/12/25 06:00 [entrez]
PHST- 2010/12/25 06:00 [pubmed]
PHST- 2011/04/16 06:00 [medline]
AID - 10.1111/j.1523-1739.2010.01573.x [doi]
PST - ppublish
SO  - Conserv Biol. 2010 Oct;24(5):1172-3. doi: 10.1111/j.1523-1739.2010.01573.x.


PMID- 21182607
OWN - NLM
STAT- MEDLINE
DCOM- 20110131
LR  - 20101224
IS  - 1365-2044 (Electronic)
IS  - 0003-2409 (Linking)
VI  - 65
IP  - 12
DP  - 2010 Dec
TI  - Testing of incapacitated patients for blood-borne disease is ethical.
PG  - 1227-8
LID - 10.1111/j.1365-2044.2010.06546.x [doi]
FAU - Harvey, D
AU  - Harvey D
FAU - Booth, C
AU  - Booth C
FAU - Buckley, H
AU  - Buckley H
FAU - Bunker, N
AU  - Bunker N
FAU - Jones, N
AU  - Jones N
FAU - Sim, M
AU  - Sim M
FAU - Sarkar, S
AU  - Sarkar S
LA  - eng
PT  - Comment
PT  - Letter
PL  - England
TA  - Anaesthesia
JT  - Anaesthesia
JID - 0370524
SB  - IM
CON - Anaesthesia. 2010 Sep;65(9):875-7. PMID: 21198481
CON - Anaesthesia. 2010 Sep;65(9):880-4. PMID: 21198483
MH  - Blood-Borne Pathogens/*isolation & purification
MH  - Humans
MH  - Infectious Disease Transmission, Patient-to-Professional/prevention & control
MH  - Informed Consent/*ethics
MH  - Intensive Care Units/ethics
MH  - Mental Competency
MH  - Needlestick Injuries/therapy
MH  - Serologic Tests/*ethics
EDAT- 2010/12/25 06:00
MHDA- 2011/02/01 06:00
CRDT- 2010/12/25 06:00
PHST- 2010/12/25 06:00 [entrez]
PHST- 2010/12/25 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
AID - 10.1111/j.1365-2044.2010.06546.x [doi]
PST - ppublish
SO  - Anaesthesia. 2010 Dec;65(12):1227-8. doi: 10.1111/j.1365-2044.2010.06546.x.


PMID- 21182598
OWN - NLM
STAT- MEDLINE
DCOM- 20110131
LR  - 20110316
IS  - 1365-2044 (Electronic)
IS  - 0003-2409 (Linking)
VI  - 65
IP  - 12
DP  - 2010 Dec
TI  - Another kind of ethics: from corrections to retractions.
PG  - 1163-6
LID - 10.1111/j.1365-2044.2010.06557.x [doi]
FAU - Yentis, S M
AU  - Yentis SM
LA  - eng
PT  - Editorial
PL  - England
TA  - Anaesthesia
JT  - Anaesthesia
JID - 0370524
SB  - IM
CIN - Anaesthesia. 2011 Mar;66(3):220-1. PMID: 21320090
MH  - Anesthesiology/*ethics
MH  - Bibliometrics
MH  - Ethics, Professional
MH  - Humans
MH  - Periodicals as Topic/*ethics
MH  - Publishing/ethics
MH  - *Retraction of Publication as Topic
EDAT- 2010/12/25 06:00
MHDA- 2011/02/01 06:00
CRDT- 2010/12/25 06:00
PHST- 2010/12/25 06:00 [entrez]
PHST- 2010/12/25 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
AID - 10.1111/j.1365-2044.2010.06557.x [doi]
PST - ppublish
SO  - Anaesthesia. 2010 Dec;65(12):1163-6. doi: 10.1111/j.1365-2044.2010.06557.x.


PMID- 21181642
OWN - NLM
STAT- MEDLINE
DCOM- 20110902
LR  - 20110412
IS  - 1438-8790 (Electronic)
IS  - 0934-8387 (Linking)
VI  - 65
IP  - 4
DP  - 2011 Apr
TI  - [Pulmonary hypertension due to chronic lung disease. Recommendations of the
      Cologne Consensus Conference 2010].
PG  - 208-18
LID - 10.1055/s-0030-1255970 [doi]
AB  - The 2009 European Guidelines on Pulmonary Hypertension did not cover only
      pulmonary arterial hypertension (PAH) but also some aspects of pulmonary
      hypertension (PH) in chronic lung disease. The European Guidelines point out that
      the drugs currently used to treat patients with PAH (prostanoids, endothelin
      receptor antagonists and phosphodiesterase-5 inhibitors) have not been
      sufficiently investigated in other forms of PH. Therefore, the European
      Guidelines do not recommend the use of these drugs in patients with chronic lung 
      disease and PH. This recommendation, however, is not always in agreement with
      medical ethics as physicians feel sometimes inclined to treat other form of
      pulmonary hypertension which may affect quality of life and survival of these
      patients in a similar manner. In June 2010, a group of German experts met in
      Cologne, Germany, to discuss open and controversial issues surrounding the
      practical implementation of the European Guidelines. The conference was sponsored
      by the German Society of Cardiology, the German Society of Respiratory Medicine
      and the German Society of Pediatric Cardiology. One of the working groups was
      dedicated to the diagnosis and treatment of PH in patients with chronic lung
      disease. The recommendations of this working group are summarized in the present 
      paper.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Hoeper, M M
AU  - Hoeper MM
AD  - Klinik fur Pneumologie, Medizinische Hochschule Hannover, Hannover.
      hoeper.marius@mh-hannover.de
FAU - Andreas, S
AU  - Andreas S
FAU - Bastian, A
AU  - Bastian A
FAU - Claussen, M
AU  - Claussen M
FAU - Ghofrani, H A
AU  - Ghofrani HA
FAU - Gorenflo, M
AU  - Gorenflo M
FAU - Grohe, C
AU  - Grohe C
FAU - Gunther, A
AU  - Gunther A
FAU - Halank, M
AU  - Halank M
FAU - Hammerl, P
AU  - Hammerl P
FAU - Held, M
AU  - Held M
FAU - Kruger, S
AU  - Kruger S
FAU - Lange, T J
AU  - Lange TJ
FAU - Reichenberger, F
AU  - Reichenberger F
FAU - Sablotzki, A
AU  - Sablotzki A
FAU - Staehler, G
AU  - Staehler G
FAU - Stark, W
AU  - Stark W
FAU - Wirtz, H
AU  - Wirtz H
FAU - Witt, C
AU  - Witt C
FAU - Behr, J
AU  - Behr J
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Pulmonale Hypertonie bei chronischen Lungenerkrankungen. Empfehlungen der Kolner 
      Konsensus-Konferenz 2010.
DEP - 20101222
PL  - Germany
TA  - Pneumologie
JT  - Pneumologie (Stuttgart, Germany)
JID - 8906641
RN  - 0 (Antihypertensive Agents)
SB  - IM
MH  - Antihypertensive Agents/*adverse effects/therapeutic use
MH  - Europe
MH  - Humans
MH  - Hypertension, Pulmonary/*drug therapy/*etiology
MH  - Lung Injury/*complications/*drug therapy
MH  - *Practice Guidelines as Topic
MH  - Pulmonary Medicine/*standards
EDAT- 2010/12/25 06:00
MHDA- 2011/09/03 06:00
CRDT- 2010/12/25 06:00
PHST- 2010/12/25 06:00 [entrez]
PHST- 2010/12/25 06:00 [pubmed]
PHST- 2011/09/03 06:00 [medline]
AID - 10.1055/s-0030-1255970 [doi]
PST - ppublish
SO  - Pneumologie. 2011 Apr;65(4):208-18. doi: 10.1055/s-0030-1255970. Epub 2010 Dec
      22.


PMID- 21181616
OWN - NLM
STAT- MEDLINE
DCOM- 20110128
LR  - 20101224
IS  - 1439-4413 (Electronic)
IS  - 0012-0472 (Linking)
VI  - 136
IP  - 1-2
DP  - 2011 Jan
TI  - [Ethics, empiricism and uncertainty].
PG  - 45-6
LID - 10.1055/s-0030-1269439 [doi]
AB  - Accidents can lead to difficult boundary situations. Such situations often take
      place in the emergency units. The medical team thus often and inevitably faces
      professional uncertainty in their decision-making. It is essential to communicate
      these uncertainties within the medical team, instead of downplaying or overriding
      existential hurdles in decision-making. Acknowledging uncertainties might lead to
      alert and prudent decisions. Thus uncertainty can have ethical value in treatment
      or withdrawal of treatment. It does not need to be covered in evidence-based
      arguments, especially as some singular situations of individual tragedies cannot 
      be grasped in terms of evidence-based medicine.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Porz, R
AU  - Porz R
AD  - Universitares Notfallzentrum - Department Anasthesie, Notfall- , Intensivmedizin 
      Inselspital Bern - Universitatsspital, 3008 Bern, Switzerland.
FAU - Zimmermann, H
AU  - Zimmermann H
FAU - Exadaktylos, A K
AU  - Exadaktylos AK
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Ethik, Empirik und Unsicherheit.
DEP - 20101221
PL  - Germany
TA  - Dtsch Med Wochenschr
JT  - Deutsche medizinische Wochenschrift (1946)
JID - 0006723
SB  - IM
MH  - *Decision Making
MH  - *Emergencies
MH  - *Ethics, Medical
MH  - Evidence-Based Medicine/standards
MH  - Humans
MH  - Research/*standards
MH  - *Uncertainty
EDAT- 2010/12/25 06:00
MHDA- 2011/02/01 06:00
CRDT- 2010/12/25 06:00
PHST- 2010/12/25 06:00 [entrez]
PHST- 2010/12/25 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
AID - 10.1055/s-0030-1269439 [doi]
PST - ppublish
SO  - Dtsch Med Wochenschr. 2011 Jan;136(1-2):45-6. doi: 10.1055/s-0030-1269439. Epub
      2010 Dec 21.


PMID- 21181455
OWN - NLM
STAT- MEDLINE
DCOM- 20111222
LR  - 20211020
IS  - 1970-9366 (Electronic)
IS  - 1828-0447 (Linking)
VI  - 6
IP  - 4
DP  - 2011 Aug
TI  - Rescuing the drowned: cardiopulmonary resuscitation and the origins of emergency 
      medicine in the eighteenth century.
PG  - 353-6
LID - 10.1007/s11739-010-0495-1 [doi]
AB  - The concept of a medical emergency, i.e., a time when immediate action is
      required to stabilize and restore the vital functions, is absent in the tradition
      of ancient medicine, which seeks to cure the sick. The theoretical and conceptual
      development of a prompt medical assistance definitely owes much to the refinement
      of instruments and surgical techniques that were develop in the early modern age,
      allowing the extension of therapeutic action to "healthy" individuals who are
      suddenly life-threatened due to an accident or to some external events that
      affect their vital functions. But it is especially in the eighteenth century that
      the epistemic basis of medical emergency is structured, when the Enlightenment
      gave rise to the ethical and political imperative of public assistance that
      required the planning of first aid at multiple levels, and medicine developed the
      concept of life-saving treatment. In particular, eighteenth century medicine,
      studying systems to assure immediate relief to the victims of
      accidents-especially to the drowned-allowed the development of specific and
      methodological systems of resuscitation and emergency treatment.
FAU - Marinozzi, Silvia
AU  - Marinozzi S
AD  - Section of History of Medicine, Department of Experimental Medicine, Sapienza
      University of Rome, Rome, Italy. silvia.marinozzi@uniroma1.it
FAU - Bertazzoni, Giuliano
AU  - Bertazzoni G
FAU - Gazzaniga, Valentina
AU  - Gazzaniga V
LA  - eng
PT  - Historical Article
PT  - Journal Article
DEP - 20101222
PL  - Italy
TA  - Intern Emerg Med
JT  - Internal and emergency medicine
JID - 101263418
SB  - IM
MH  - Cardiopulmonary Resuscitation/history/instrumentation/*methods
MH  - Drowning/*history
MH  - Emergency Medicine/*history
MH  - History, 18th Century
MH  - Humans
EDAT- 2010/12/25 06:00
MHDA- 2011/12/23 06:00
CRDT- 2010/12/25 06:00
PHST- 2010/07/21 00:00 [received]
PHST- 2010/11/23 00:00 [accepted]
PHST- 2010/12/25 06:00 [entrez]
PHST- 2010/12/25 06:00 [pubmed]
PHST- 2011/12/23 06:00 [medline]
AID - 10.1007/s11739-010-0495-1 [doi]
PST - ppublish
SO  - Intern Emerg Med. 2011 Aug;6(4):353-6. doi: 10.1007/s11739-010-0495-1. Epub 2010 
      Dec 22.


PMID- 21181089
OWN - NLM
STAT- MEDLINE
DCOM- 20110607
LR  - 20101224
IS  - 1972-6007 (Electronic)
IS  - 0009-9074 (Linking)
VI  - 161
IP  - 6
DP  - 2010
TI  - TACT glossary: technoscience.
PG  - 569-71
AB  - The term technoscience (T) indicates the complex interactions between
      contemporary science and technology, that have become practically inseparable.
      From an epistemological point of view, T only considers the quantitative
      knowledge in a reductionist way. Nature has been reduced to a machine that works 
      according to laws learnt through the experimental science. At present, technical 
      efficiency represents an operational dominion on Nature; it gives the power to
      those who possess it. Scientists, considered as visionaries, have the assignment 
      to lead society. They create new cosmos-visions that are technocentric, thus Ts
      use the human being as subject of experimentation and they transform some
      essential dimensions of the human being. All this suggests the necessity of an
      ethical evaluation of the action integration of different subjects in what we
      call integrated action. This configuration involves ethical obligations for the
      agent: he/she has to act preserving and allowing the collaboration, and
      respecting the professional's individual responsibility.
FAU - Tambone, V
AU  - Tambone V
AD  - Institute of Philosophy of Scientific and Technological Activity. University
      Campus Bio-Medico of Rome, Via Alvaro del Portillo 21, Rome, Italy.
FAU - Pennacchini, M
AU  - Pennacchini M
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Clin Ter
JT  - La Clinica terapeutica
JID - 0372604
SB  - IM
MH  - *Dictionaries as Topic
MH  - European Union
MH  - Forecasting
MH  - Humans
MH  - Philosophy
MH  - *Science/ethics/methods
MH  - Social Change
MH  - Social Responsibility
MH  - *Technology/ethics
EDAT- 2010/12/25 06:00
MHDA- 2011/06/08 06:00
CRDT- 2010/12/25 06:00
PHST- 2010/12/25 06:00 [entrez]
PHST- 2010/12/25 06:00 [pubmed]
PHST- 2011/06/08 06:00 [medline]
PST - ppublish
SO  - Clin Ter. 2010;161(6):569-71.


PMID- 21180846
OWN - NLM
STAT- MEDLINE
DCOM- 20110606
LR  - 20191111
IS  - 1980-5497 (Electronic)
IS  - 1415-790X (Linking)
VI  - 13
IP  - 4
DP  - 2010 Dec
TI  - [Death and its epidemiological investigation: considerations about some relevant 
      aspects].
PG  - 561-76
LID - S1415-790X2010000400002 [pii]
AB  - This article addresses death and issues related to its investigation, as
      important components for Epidemiology/Public Health. It highlights aspects linked
      to the improvement of quality of investigation and surveillance of death, as well
      as the advance of scientific/epidemiological research in this area, analyzed in
      view of current legislation and ethical principles in Brazil. We discuss the
      problem related to knowing "whom the health information belongs to and which are 
      the limits of its utilization", considering also the possibility of using
      identified databases. At the end, we suggest competent ways, as a "Term of
      Responsibility/Confidentiality" signed by the researcher in order to enable
      scientific/epidemiological research to continue in the country, in a more
      opportune and agile manner.
FAU - Jorge, Maria Helena P de Mello
AU  - Jorge MH
AD  - Faculdade de Saude Publica, Universidade de Sao Paulo, Brazil.
FAU - Laurenti, Ruy
AU  - Laurenti R
FAU - Di Nubila, Heloisa Brunow Ventura
AU  - Di Nubila HB
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - O obito e sua investigacao: reflexoes sobre alguns aspectos relevantes.
PL  - Brazil
TA  - Rev Bras Epidemiol
JT  - Revista brasileira de epidemiologia = Brazilian journal of epidemiology
JID - 100954576
SB  - IM
MH  - Brazil
MH  - *Epidemiologic Studies
MH  - Humans
MH  - Mortality/*trends
EDAT- 2010/12/25 06:00
MHDA- 2011/06/07 06:00
CRDT- 2010/12/25 06:00
PHST- 2010/09/01 00:00 [received]
PHST- 2010/09/01 00:00 [accepted]
PHST- 2010/12/25 06:00 [entrez]
PHST- 2010/12/25 06:00 [pubmed]
PHST- 2011/06/07 06:00 [medline]
AID - S1415-790X2010000400002 [pii]
AID - 10.1590/s1415-790x2010000400002 [doi]
PST - ppublish
SO  - Rev Bras Epidemiol. 2010 Dec;13(4):561-76. doi: 10.1590/s1415-790x2010000400002.


PMID- 21180294
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20101224
IS  - 1029-4864 (Print)
IS  - 1029-4864 (Linking)
VI  - 65
IP  - 9
DP  - 2010 Oct
TI  - Dental ethics case 6. Stalled payment for ongoing orthodontic
      treatment--balancing responsibilities.
PG  - 434-5
AB  - It is not always easy for an orthodontist to strike the right balance between a
      caring, supportive and patient-centered approach, and the need to make a living
      and to run a profitable business in order to achieve this. Striving to act
      ethically and professionally at all times will help find this elusive balance and
      ultimately it will be more rewarding and professionally satisfying. Especially
      when dealing with children whose lives may be dramatically affected by the
      interruption or cessation of treatment, orthodontists have a duty to reassure
      themselves about the financial stability of their contractual relationships with 
      patients or parents. Having consistent financial policies and flexible payment
      options may assist in this regard. Even in the face of non-payment of fees,
      treatments that have begun must in some form continue if their cessation would
      compromise the best interests of patients.
FAU - Doyal, L
AU  - Doyal L
AD  - Medical Ethics, St Barts and The London Medical Hospital, Queen Mary, University 
      of London.
FAU - Naidoo, S
AU  - Naidoo S
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - SADJ
JT  - SADJ : journal of the South African Dental Association = tydskrif van die
      Suid-Afrikaanse Tandheelkundige Vereniging
JID - 9812497
MH  - Child
MH  - Contracts/*ethics
MH  - Dentist-Patient Relations/ethics
MH  - Dentists/ethics
MH  - *Ethics, Dental
MH  - Humans
MH  - Orthodontics, Corrective/economics/*ethics
MH  - Parents
MH  - Patient Credit and Collection/*ethics
MH  - Professional-Family Relations/ethics
MH  - Refusal to Treat/ethics
MH  - Social Responsibility
MH  - Uncompensated Care/ethics
EDAT- 2010/12/25 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/12/25 06:00
PHST- 2010/12/25 06:00 [entrez]
PHST- 2010/12/25 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
PST - ppublish
SO  - SADJ. 2010 Oct;65(9):434-5.


PMID- 21179885
OWN - NLM
STAT- MEDLINE
DCOM- 20110110
LR  - 20101222
IS  - 0023-7205 (Print)
IS  - 0023-7205 (Linking)
VI  - 107
IP  - 44
DP  - 2010 Nov 3-9
TI  - [Ethics police or appeal to ethical reflection?].
PG  - 2736
FAU - Engstrom, Ingemar
AU  - Engstrom I
FAU - Lynoe, Niels
AU  - Lynoe N
FAU - Flodin, Thomas
AU  - Flodin T
LA  - swe
PT  - Comment
PT  - Letter
TT  - Etikpoliser eller appell till etisk reflexion?
PL  - Sweden
TA  - Lakartidningen
JT  - Lakartidningen
JID - 0027707
SB  - IM
CON - Lakartidningen. 2010 Oct 27-Nov 2;107(43):2658. PMID: 21137536
MH  - *Ethics, Medical
MH  - Sweden
EDAT- 2010/12/25 06:00
MHDA- 2011/01/11 06:00
CRDT- 2010/12/25 06:00
PHST- 2010/12/25 06:00 [entrez]
PHST- 2010/12/25 06:00 [pubmed]
PHST- 2011/01/11 06:00 [medline]
PST - ppublish
SO  - Lakartidningen. 2010 Nov 3-9;107(44):2736.


PMID- 21179461
OWN - NLM
STAT- MEDLINE
DCOM- 20110705
LR  - 20211020
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 5
IP  - 12
DP  - 2010 Dec 14
TI  - Physician attitudes towards pharmacological cognitive enhancement: safety
      concerns are paramount.
PG  - e14322
LID - 10.1371/journal.pone.0014322 [doi]
AB  - The ethical dimensions of pharmacological cognitive enhancement have been widely 
      discussed in academic circles and the popular media, but missing from the
      conversation have been the perspectives of physicians - key decision makers in
      the adoption of new technologies into medical practice. We queried primary care
      physicians in major urban centers in Canada and the United States with the aim of
      understanding their attitudes towards cognitive enhancement. Our primary
      hypothesis was that physicians would be more comfortable prescribing cognitive
      enhancers to older patients than to young adults. Physicians were presented with 
      a hypothetical pharmaceutical cognitive enhancer that had been approved by the
      regulatory authorities for use in healthy adults, and was characterized as being 
      safe, effective, and without significant adverse side effects. Respondents
      overwhelmingly reported increasing comfort with prescribing cognitive enhancers
      as the patient age increased from 25 to 65. When asked about their comfort with
      prescribing extant drugs that might be considered enhancements (sildenafil,
      modafinil, and methylphenidate) or our hypothetical cognitive enhancer to a
      normal, healthy 40 year old, physicians were more comfortable prescribing
      sildenafil than any of the other three agents. When queried as to the reasons
      they answered as they did, the most prominent concerns physicians expressed were 
      issues of safety that were not offset by the benefit afforded the individual,
      even in the face of explicit safety claims. Moreover, many physicians indicated
      that they viewed safety claims with considerable skepticism. It has become
      routine for safety to be raised and summarily dismissed as an issue in the debate
      over pharmacological cognitive enhancement; the observation that physicians were 
      so skeptical in the face of explicit safety claims suggests that such a
      conclusion may be premature. Thus, physician attitudes suggest that greater
      weight be placed upon the balance between safety and benefit in consideration of 
      pharmacological cognitive enhancement.
FAU - Banjo, Opeyemi C
AU  - Banjo OC
AD  - National Core for Neuroethics, University of British Columbia, Vancouver, British
      Columbia, Canada.
FAU - Nadler, Roland
AU  - Nadler R
FAU - Reiner, Peter B
AU  - Reiner PB
LA  - eng
GR  - F08-04061/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101214
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Nootropic Agents)
RN  - 0 (Piperazines)
RN  - 0 (Purines)
RN  - 0 (Sulfones)
RN  - 207ZZ9QZ49 (Methylphenidate)
RN  - BW9B0ZE037 (Sildenafil Citrate)
RN  - R3UK8X3U3D (Modafinil)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Benzhydryl Compounds/pharmacology
MH  - Central Nervous System Stimulants/pharmacology
MH  - Cognition/*drug effects
MH  - Cognition Disorders/drug therapy
MH  - Drug Therapy/*psychology
MH  - Drug Utilization/*standards
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Male
MH  - Methylphenidate/pharmacology
MH  - Middle Aged
MH  - Modafinil
MH  - Nootropic Agents/*pharmacology
MH  - Physicians/*psychology
MH  - Piperazines/pharmacology
MH  - Practice Patterns, Physicians'
MH  - Purines/pharmacology
MH  - Safety
MH  - Sildenafil Citrate
MH  - Sulfones/pharmacology
PMC - PMC3001858
EDAT- 2010/12/24 06:00
MHDA- 2011/07/06 06:00
CRDT- 2010/12/24 06:00
PHST- 2010/07/06 00:00 [received]
PHST- 2010/11/17 00:00 [accepted]
PHST- 2010/12/24 06:00 [entrez]
PHST- 2010/12/24 06:00 [pubmed]
PHST- 2011/07/06 06:00 [medline]
AID - 10.1371/journal.pone.0014322 [doi]
PST - epublish
SO  - PLoS One. 2010 Dec 14;5(12):e14322. doi: 10.1371/journal.pone.0014322.


PMID- 21178913
OWN - NLM
STAT- MEDLINE
DCOM- 20110414
LR  - 20220318
IS  - 1827-1596 (Electronic)
IS  - 0375-9393 (Linking)
VI  - 76
IP  - 12
DP  - 2010 Dec
TI  - Extracorporeal membrane oxygenation for pandemic H1N1 2009 respiratory failure.
PG  - 1043-51
AB  - BACKGROUND: Severe respiratory failure related to infection with the pandemic
      influenza A/H1N1 2009 virus is uncommon but possibly life-threatening. If, in
      spite of maximal conventional critical care, the patient's condition
      deteriorates, extracorporeal membrane oxygenation (ECMO) may be a life-saving
      procedure. METHODS: An observational study approved by the local ethics committee
      was carried out. Data from all patients treated with ECMO at the ECMO Center
      Karolinska for influenza A/H1N1 2009-related severe respiratory failure were
      analyzed. The main outcome measure was survival three months after discharge from
      our department. RESULTS: Between July 2009 and January 2010, 13 patients with
      H1N1 2009 respiratory failure were treated with ECMO. Twelve patients were
      cannulated for veno-venous ECMO at the referring hospital and transported to
      Stockholm. One patient was cannulated in our hospital for veno-arterial support. 
      The median ratio of the arterial partial oxygen pressure to the fraction of
      inspired oxygen (P/F ratio: PaO2 /FiO2) before cannulation was 52.5
      (interquartile range 38-60). Four patients were converted from veno-venous to
      veno-arterial ECMO because of right heart failure (three) or life-threatening
      cardiac arrhythmias (one). The median maximum oxygen consumption via ECMO was 251
      ml/min (187-281 ml/min). Twelve patients were still alive three months after
      discharge; one patient died four days after discharge due to intracranial
      hemorrhage. CONCLUSION: Patients treated with veno-venous or veno-arterial ECMO
      for H1N1 2009-related respiratory failure may have a favorable outcome.
      Contributing factors may include the possibility of transport on ECMO, conversion
      from veno-venous (v-v) or veno-arterial (v-a) ECMO if necessary, high-flow ECMO
      to meet oxygen requirements and active surgery when needed.
FAU - Holzgraefe, B
AU  - Holzgraefe B
AD  - Section for Anaesthesiology and Intensive Care Medicine, Department of Physiology
      and Pharmacology, Paediatric Anaesthesia and Intensive Care, ECMO Center
      Karolinska, Karolinska Institute and Karolinska University Hospital Solna,
      Stockholm, Sweden. bernhard.holzgraefe@karolinska.se
FAU - Broome, M
AU  - Broome M
FAU - Kalzen, H
AU  - Kalzen H
FAU - Konrad, D
AU  - Konrad D
FAU - Palmer, K
AU  - Palmer K
FAU - Frenckner, B
AU  - Frenckner B
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Minerva Anestesiol
JT  - Minerva anestesiologica
JID - 0375272
RN  - 0 (Analgesics)
RN  - 0 (Hypnotics and Sedatives)
SB  - IM
CIN - Minerva Anestesiol. 2010 Dec;76(12):989-91. PMID: 21178910
MH  - Adult
MH  - Analgesics/therapeutic use
MH  - Cohort Studies
MH  - Cross Infection/therapy
MH  - *Extracorporeal Membrane Oxygenation/adverse effects/instrumentation
MH  - Female
MH  - Humans
MH  - Hypnotics and Sedatives/therapeutic use
MH  - Hypoxia/therapy
MH  - *Influenza A Virus, H1N1 Subtype
MH  - Influenza, Human/complications/*therapy/virology
MH  - Male
MH  - Middle Aged
MH  - Pandemics
MH  - Pregnancy
MH  - Respiration, Artificial
MH  - Respiratory Function Tests
MH  - Respiratory Insufficiency/etiology/*therapy/virology
MH  - Treatment Outcome
EDAT- 2010/12/24 06:00
MHDA- 2011/04/16 06:00
CRDT- 2010/12/24 06:00
PHST- 2010/12/24 06:00 [entrez]
PHST- 2010/12/24 06:00 [pubmed]
PHST- 2011/04/16 06:00 [medline]
AID - R02106443 [pii]
PST - ppublish
SO  - Minerva Anestesiol. 2010 Dec;76(12):1043-51.


PMID- 21178906
OWN - NLM
STAT- MEDLINE
DCOM- 20110503
LR  - 20170306
VI  - 120
IP  - 12
DP  - 2010 Dec
TI  - Management of cardiac electrical implantable devices in patients nearing the end 
      of life or requesting withdrawal of therapy: review of the Heart Rhythm Society
      2010 consensus statement.
PG  - 497-502
LID - 508 [pii]
AB  - Cardiac implantable electrical devices (CIEDs) are increasingly common
      interventions for a wide spectrum of cardiovascular diseases. Caring for patients
      with life-sustaining devices such as CIEDs at the end of life raises legal and
      ethical challenges. In 2010, the Heart Rhythm Society (HRS) published an expert
      consensus statement to review the principles and practice of CIED deactivation.
      This statement addressed a wide range of ethical and legal principles while
      providing guidance for communication, decision-making, and procedures in a
      variety of settings. In this article, we provide a summary of the HRS guidelines 
      and highlight the most important features of CIED deactivation for the practicing
      clinician.
FAU - Kramer, Daniel B
AU  - Kramer DB
AD  - The Cardiovascular Institute, Beth Isreal Deaconess Medical Center, harvard
      Medical School Boston, Massachusetts, United States. mueller.pauls@mayo.edu
FAU - Ottenberg, Abigale L
AU  - Ottenberg AL
FAU - Mueller, Paul S
AU  - Mueller PS
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Poland
TA  - Pol Arch Med Wewn
JT  - Polskie Archiwum Medycyny Wewnetrznej
JID - 0401225
SB  - IM
MH  - Consensus
MH  - Defibrillators, Implantable/*ethics
MH  - Device Removal/*ethics/legislation & jurisprudence
MH  - Female
MH  - Humans
MH  - Male
MH  - Withholding Treatment/*ethics/legislation & jurisprudence
EDAT- 2010/12/24 06:00
MHDA- 2011/05/04 06:00
CRDT- 2010/12/24 06:00
PHST- 2010/12/24 06:00 [entrez]
PHST- 2010/12/24 06:00 [pubmed]
PHST- 2011/05/04 06:00 [medline]
PST - ppublish
SO  - Pol Arch Med Wewn. 2010 Dec;120(12):497-502.


PMID- 21178853
OWN - NLM
STAT- MEDLINE
DCOM- 20110201
LR  - 20110304
IS  - 1530-0358 (Electronic)
IS  - 0012-3706 (Linking)
VI  - 53
IP  - 12
DP  - 2010 Dec
TI  - Magnetic anal sphincter augmentation for the treatment of fecal incontinence: a
      preliminary report from a feasibility study.
PG  - 1604-10
LID - 10.1007/DCR.0b013e3181f5d5f7 [doi]
AB  - BACKGROUND: Magnetic sphincter augmentation, a successful treatment of
      gastroesophageal reflux disease, has been applied to treat fecal incontinence.
      The purpose of this feasibility study was to understand the safety profile as
      well as the potential benefit of this new device when it is implanted in patients
      with fecal incontinence. METHODS: A magnetic anal sphincter device was surgically
      implanted in candidates with documented fecal incontinence of more than 2
      episodes per week at 3 investigational centers in Europe and the United States
      following ethics/institutional review board approval. The magnetic anal sphincter
      device was placed around the anal canal via a single anterior incision. All data 
      were collected prospectively. The primary outcome measure was the reduction of
      incontinent episodes based on a daily continence diary. RESULTS: To date 14
      patients have been implanted with the device (all female; mean age, 62.8 y;
      range, 41-74 y) with a median follow-up of 6 months. There have been no
      intraoperative complications. Mean hospital stay was 3 days; range, 1 to 7 days. 
      Adverse events were observed in 7 patients. Three patients are no longer
      implanted with a device; 2 devices were removed and one passed spontaneously
      following a separation at the suture connection. Five patients with 6-month
      follow-up demonstrated a mean reduction in the number of average weekly
      incontinence episodes from 7.2 to 0.7 (90.9%) and a mean reduction in Wexner
      Continence Score from 17.2 to 7.8 (54.7%). Compared with baseline, quality of
      life improved in all 4 domains of the fecal incontinence quality of life (FIQoL) 
      scoring system. No patients have reported that their condition has worsened. Two 
      patients at 1-year follow-up both reported perfect continence. CONCLUSION: This
      preliminary study describes the use of a new device to treat fecal incontinence. 
      Compared with existing devices, implantation is simple and it requires no
      adjustments from the physician or patient once the device is implanted. Initial
      assessment with a small number of patients shows promising outcomes with a
      limited incidence of complications and good restoration of continence.
FAU - Lehur, Paul-Antoine
AU  - Lehur PA
AD  - Department of Digestive and Endocrine Surgery, University Hospital of Nantes,
      Nantes, France. paulantoine.lehur@chu-nantes.fr
FAU - McNevin, Shane
AU  - McNevin S
FAU - Buntzen, Steen
AU  - Buntzen S
FAU - Mellgren, Anders F
AU  - Mellgren AF
FAU - Laurberg, Soeren
AU  - Laurberg S
FAU - Madoff, Robert D
AU  - Madoff RD
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - United States
TA  - Dis Colon Rectum
JT  - Diseases of the colon and rectum
JID - 0372764
SB  - IM
CIN - Nat Rev Gastroenterol Hepatol. 2011 Feb;8(2):66. PMID: 21381249
MH  - Adult
MH  - Aged
MH  - Anal Canal/*surgery
MH  - Europe
MH  - Feasibility Studies
MH  - Fecal Incontinence/*surgery
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Length of Stay/statistics & numerical data
MH  - Magnetic Field Therapy/instrumentation/*methods
MH  - Middle Aged
MH  - Postoperative Complications
MH  - Prospective Studies
MH  - *Prostheses and Implants
MH  - Prosthesis Design
MH  - Prosthesis Implantation/methods
MH  - Quality of Life
MH  - Treatment Outcome
MH  - United States
EDAT- 2010/12/24 06:00
MHDA- 2011/02/02 06:00
CRDT- 2010/12/24 06:00
PHST- 2010/12/24 06:00 [entrez]
PHST- 2010/12/24 06:00 [pubmed]
PHST- 2011/02/02 06:00 [medline]
AID - 10.1007/DCR.0b013e3181f5d5f7 [doi]
AID - 00003453-201012000-00003 [pii]
PST - ppublish
SO  - Dis Colon Rectum. 2010 Dec;53(12):1604-10. doi: 10.1007/DCR.0b013e3181f5d5f7.


PMID- 21178494
OWN - NLM
STAT- MEDLINE
DCOM- 20110804
LR  - 20211020
IS  - 2150-5608 (Electronic)
IS  - 2150-5594 (Linking)
VI  - 1
IP  - 6
DP  - 2010 Nov-Dec
TI  - The growing promise of Toll-deficient Drosophila melanogaster as a model for
      studying Aspergillus pathogenesis and treatment.
PG  - 488-99
AB  - Despite considerable progress over recent years, the prognosis of invasive
      aspergillosis (IA) remains unfavorable, reflecting an incomplete understanding of
      Aspergillus pathogenesis and suboptimal antifungal efficacy in vivo. Mammalian
      host systems including rodents and rabbits are important tools in elucidating
      antifungal drug activity and the immunopathogenesis of IA. Nonetheless, they are 
      hampered by limitations that impose a "bottleneck" in mass screening of novel
      antifungal compounds and putative Aspergillus virulence factors including their
      cost, labor intensity and ethical constraints. Drosophila melanogaster is an
      invertebrate host with a long tract record of genetic studies and a simple, yet
      highly conserved innate immune system. Herein, we describe our experience using
      this fly model as a facile, non-laborious, inexpensive pathosystem for
      high-throughput screening of novel antifungal compounds and putative Aspergillus 
      mutants, and studying antifungal innate immunity. We present three infection
      protocols (i.e., injection, rolling, ingestion) that introduce Aspergillus either
      directly into the hemolymph or at different epithelial surfaces of Toll-deficient
      Drosophila flies. As a proof of principle, we demonstrate attenuated virulence of
      known hypovirulent Aspergillus strains and protection of Aspergillus-infected
      flies given oral Aspergillus-active agents such is voriconazole. These protocols 
      can be adapted for similar studies of other fungal pathogens. Crossing and
      generation of Toll-deficient Drosophila flies takes 3 weeks; Aspergillus conidial
      preparation takes 3 days; fly inoculation depending on the infection assay takes 
      1 to 6-8 hours; and assessment of fly survival, Aspergillus strain virulence,
      Drosophila innate host parameters and/or drug activity takes 4-8 days.
FAU - Lionakis, Michail S
AU  - Lionakis MS
AD  - Laboratory of Molecular Immunology, National Institutes of Health, Bethesda, MD, 
      USA.
FAU - Kontoyiannis, Dimitrios P
AU  - Kontoyiannis DP
LA  - eng
GR  - P30 CA016672/CA/NCI NIH HHS/United States
GR  - CA016672/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20101101
PL  - United States
TA  - Virulence
JT  - Virulence
JID - 101531386
RN  - 0 (Antifungal Agents)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Toll-Like Receptors)
SB  - IM
MH  - Animals
MH  - Antifungal Agents/*pharmacology
MH  - Aspergillus/*drug effects/*pathogenicity
MH  - Drosophila Proteins/deficiency/*genetics
MH  - Drosophila melanogaster/genetics/immunology/*microbiology
MH  - Eating
MH  - Gene Deletion
MH  - High-Throughput Screening Assays
MH  - Injections
MH  - Microbial Sensitivity Tests
MH  - Models, Animal
MH  - Toll-Like Receptors/deficiency/*genetics
MH  - Virulence
PMC - PMC3073358
EDAT- 2010/12/24 06:00
MHDA- 2011/08/05 06:00
CRDT- 2010/12/24 06:00
PHST- 2010/12/24 06:00 [entrez]
PHST- 2010/12/24 06:00 [pubmed]
PHST- 2011/08/05 06:00 [medline]
AID - 13311 [pii]
AID - 10.4161/viru.1.6.13311 [doi]
PST - ppublish
SO  - Virulence. 2010 Nov-Dec;1(6):488-99. doi: 10.4161/viru.1.6.13311. Epub 2010 Nov
      1.


PMID- 21178372
OWN - NLM
STAT- MEDLINE
DCOM- 20110324
LR  - 20220316
IS  - 0254-5020 (Print)
IS  - 0076-6070 (Linking)
VI  - 56
DP  - 2011
TI  - Environmental factors affecting elite young athletes.
PG  - 150-170
LID - 10.1159/000320646 [doi]
AB  - To date, much of the research concerning the performance of elite young athletes 
      has focused on physical and physiological factors and how these relate to age and
      maturation. Little attention has been paid to other factors which might limit
      performance such as nutrition or environmental stressors. The paucity of research
      on the environmental effects on performance in young athletes is unsurprising
      given the need for experimental studies, the ethics of which would generally be
      untenable. As an outcome, there is a reliance on observational and case study
      data, e.g. observing the stressors which occur during jet lag and effects on
      sleep patterns, altitude and pollution. The effects of environmental factors have
      been predominantly researched from a health context in youngsters rather than a
      performance context. However, the evidence of those few empirical studies
      combined with coach and/or sports science support teams' experience have provided
      professionals with some guidelines. These applied guidelines include sleep
      patterns, jet lag, pollution and altitude research, to aid those preparing young 
      athletes for training and competition in environments that present potential
      challenges to performance. The limitations of data extrapolated from adults are
      acknowledged and in all cases it is emphasised that recommendations and
      implementing practice should be based on data collected from young people.
CI  - Copyright (c) 2011 S. Karger AG, Basel.
FAU - Williams, Craig
AU  - Williams C
AD  - Children's Health and Exercise Research Centre, University of Exeter, Exeter, UK.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20101221
PL  - Switzerland
TA  - Med Sport Sci
JT  - Medicine and sport science
JID - 8402440
SB  - IM
MH  - Adolescent
MH  - Air Pollution/*adverse effects
MH  - *Altitude
MH  - Athletic Performance/*physiology
MH  - Child
MH  - Circadian Rhythm/*physiology
MH  - *Environment
MH  - Humans
MH  - Jet Lag Syndrome/*physiopathology
EDAT- 2010/12/24 06:00
MHDA- 2011/03/25 06:00
CRDT- 2010/12/24 06:00
PHST- 2010/12/24 06:00 [entrez]
PHST- 2010/12/24 06:00 [pubmed]
PHST- 2011/03/25 06:00 [medline]
AID - 000320646 [pii]
AID - 10.1159/000320646 [doi]
PST - ppublish
SO  - Med Sport Sci. 2011;56:150-170. doi: 10.1159/000320646. Epub 2010 Dec 21.


PMID- 21177396
OWN - NLM
STAT- MEDLINE
DCOM- 20110317
LR  - 20151119
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 258
IP  - 2
DP  - 2011 Feb
TI  - Breast cancer: early- and late-fluorescence near-infrared imaging with
      indocyanine green--a preliminary study.
PG  - 409-16
LID - 10.1148/radiol.10100258 [doi]
AB  - PURPOSE: To assess early- and late-fluorescence near-infrared imaging,
      corresponding to the vascular (early-fluorescence) and extravascular
      (late-fluorescence) phases of indocyanine green (ICG) enhancement, for breast
      cancer detection and benign versus malignant breast lesion differentiation.
      MATERIALS AND METHODS: The study was approved by the ethical review board; all
      participants provided written informed consent. Twenty women with 21 breast
      lesions were examined with near-infrared imaging before, during, and after
      intravenous injection of ICG. Absorption and fluorescence projection mammograms
      were recorded simultaneously on a prototype near-infrared imaging unit. Two
      blinded readers independently assessed the images and assigned visibility scores 
      to lesions seen on the absorption and absorption-corrected fluorescence
      mammograms. Imaging results were compared with histopathologic findings. Lesion
      contrast and diameter on the fluorescence mammograms were measured, and Cohen
      kappa, Mann-Whitney U, and Spearman rho tests were conducted. RESULTS: The
      absorption-corrected fluorescence ratio mammograms showed high contrast (contrast
      value range, 0.25-0.64) between tumors and surrounding breast tissue. Malignant
      lesions were correctly defined in 11 (reader 1) and 12 (reader 2) of 13 cases,
      and benign lesions were correctly defined in six (reader 1) and five (reader 2)
      of eight cases with late-fluorescence imaging. Lesion visibility scores for
      malignant and benign lesions were significantly different on the fluorescence
      ratio mammograms (P = .003) but not on the absorption mammograms (P = .206). Mean
      sensitivity and specificity reached 92% +/- 8 (standard error of mean) and 75%
      +/- 16, respectively, for fluorescence ratio imaging compared with 100% +/- 0 and
      25% +/- 16, respectively, for conventional mammography alone. CONCLUSION:
      Preliminary data suggest that early- and late-fluorescence ratio imaging after
      ICG administration can be used to distinguish malignant from benign breast
      lesions.
CI  - (c) RSNA, 2010.
FAU - Poellinger, Alexander
AU  - Poellinger A
AD  - Department of Radiology and Radiation Therapy, Charite Campus Virchow Klinikum,
      Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin,
      Germany. alexander.poellinger@charite.de
FAU - Burock, Susen
AU  - Burock S
FAU - Grosenick, Dirk
AU  - Grosenick D
FAU - Hagen, Axel
AU  - Hagen A
FAU - Ludemann, Lutz
AU  - Ludemann L
FAU - Diekmann, Felix
AU  - Diekmann F
FAU - Engelken, Florian
AU  - Engelken F
FAU - Macdonald, Rainer
AU  - Macdonald R
FAU - Rinneberg, Herbert
AU  - Rinneberg H
FAU - Schlag, Peter-Michael
AU  - Schlag PM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101221
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Coloring Agents)
RN  - IX6J1063HV (Indocyanine Green)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Breast Neoplasms/*diagnosis/pathology
MH  - *Coloring Agents/pharmacokinetics
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - *Indocyanine Green/pharmacokinetics
MH  - Mammography
MH  - Middle Aged
MH  - *Spectroscopy, Near-Infrared
MH  - Statistics, Nonparametric
EDAT- 2010/12/24 06:00
MHDA- 2011/03/18 06:00
CRDT- 2010/12/24 06:00
PHST- 2010/12/24 06:00 [entrez]
PHST- 2010/12/24 06:00 [pubmed]
PHST- 2011/03/18 06:00 [medline]
AID - radiol.10100258 [pii]
AID - 10.1148/radiol.10100258 [doi]
PST - ppublish
SO  - Radiology. 2011 Feb;258(2):409-16. doi: 10.1148/radiol.10100258. Epub 2010 Dec
      21.


PMID- 21177387
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20151119
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 258
IP  - 3
DP  - 2011 Mar
TI  - Evolution of femoral condylar ossification at MR imaging: frequency and patient
      age distribution.
PG  - 880-8
LID - 10.1148/radiol.10101103 [doi]
AB  - PURPOSE: To determine how the magnetic resonance (MR) signal intensity seen with 
      variability in distal femoral epiphyseal ossification in children varies with (a)
      age, (b) sex, (c) distribution to the medial or lateral condyles, and (d)
      residual physeal cartilage. MATERIALS AND METHODS: Ethics committee approval was 
      obtained, and informed patient consent was waived. Two pediatric radiologists
      retrospectively reviewed the consecutive knee MR imaging studies of 910 children 
      (457 boys, 453 girls; age range, 0.7-16.9 years) for variability in ossification 
      and categorized the variability as preossification center, early ossification
      center, puzzle piece, incomplete puzzle piece, spiculation, or accessory
      ossification center. Patient age and sex, ossification variability site, residual
      physeal cartilage, and associated findings were analyzed. Basic descriptive
      statistical analysis, Student t tests for comparison of continuous variables, and
      kappa statistics analysis of interobserver agreement were performed where
      appropriate. RESULTS: In 202 (22.2%) patients (278 condyles), ossification
      variability was present. In the 910 patients, early ossification center (n = 172,
      18.9%) and spiculated configuration of the secondary ossification center (n =
      151, 16.6%) were the most common variants. Preossification center (50 [5.5%]
      patients), puzzle piece (26 [2.9%] patients), accessory ossification center (nine
      [1.0%] patients), and incomplete puzzle piece (two [0.2%] patients) were seen
      less often. Ossification variability was more common in the medial condyles (169 
      [18.6%] of 910 cases) than in the lateral condyles (109 [12.0%] of 910 cases),
      nearly always posteriorly located (277 [99.6%] of 278 condyles), and more common 
      in boys (153/457 [33.5%]) than in girls (49/453 [10.8%]). Ossification
      variability was less common with decreasing residual physeal cartilage. Peak
      patient age ranges for ossification variability were 2-12 years for boys and 2-10
      years for girls. CONCLUSION: Ossification variability in the femoral condyles is 
      common in children and should not be confused with abnormal processes.
CI  - (c) RSNA, 2010.
FAU - Jans, Lennart B O
AU  - Jans LB
AD  - Department of Radiology and Medical Imaging, Ghent University Hospital, De
      Pintelaan 185, 9000 Gent, Belgium. lennartjans@hotmail.com
FAU - Jaremko, Jacob L
AU  - Jaremko JL
FAU - Ditchfield, Michael
AU  - Ditchfield M
FAU - Verstraete, Koenraad L
AU  - Verstraete KL
LA  - eng
PT  - Journal Article
DEP - 20101221
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adolescent
MH  - Age Distribution
MH  - Age Factors
MH  - Child
MH  - Child, Preschool
MH  - Contrast Media
MH  - Epiphyses/*anatomy & histology/pathology
MH  - Female
MH  - Femur/*anatomy & histology/pathology
MH  - Gadolinium DTPA
MH  - Humans
MH  - Infant
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Reference Values
MH  - Retrospective Studies
MH  - Sex Factors
EDAT- 2010/12/24 06:00
MHDA- 2011/06/03 06:00
CRDT- 2010/12/24 06:00
PHST- 2010/12/24 06:00 [entrez]
PHST- 2010/12/24 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
AID - radiol.10101103 [pii]
AID - 10.1148/radiol.10101103 [doi]
PST - ppublish
SO  - Radiology. 2011 Mar;258(3):880-8. doi: 10.1148/radiol.10101103. Epub 2010 Dec 21.


PMID- 21176882
OWN - NLM
STAT- MEDLINE
DCOM- 20110606
LR  - 20211020
IS  - 1096-7206 (Electronic)
IS  - 1096-7192 (Linking)
VI  - 102
IP  - 3
DP  - 2011 Mar
TI  - Research challenges in central nervous system manifestations of inborn errors of 
      metabolism.
PG  - 326-38
LID - 10.1016/j.ymgme.2010.11.164 [doi]
AB  - The Research Challenges in CNS Manifestations of Inborn Errors of Metabolism
      workshop was designed to address challenges in translating potential therapies
      for these rare disorders, and to highlight novel therapeutic strategies and
      innovative approaches to CNS delivery, assessment of effects and directions for
      the future in the treatment of these diseases. Therapies for the brain in inborn 
      errors represent some of the greatest challenges to translational research due to
      the special properties of the brain, and of inborn errors themselves. This review
      covers the proceedings of this workshop as submitted by participants. Scientific,
      ethical and regulatory issues are discussed, along with ways to measure outcomes 
      and the conduct of clinical trials. Participants included regulatory and funding 
      agencies, clinicians, scientists, industry and advocacy groups.
CI  - Published by Elsevier Inc.
FAU - Dickson, P I
AU  - Dickson PI
AD  - Department of Pediatrics, LA Biomedical Research Institute at Harbor-UCLA, 1124
      W. Carson St, HH1, Torrance, CA 90502, USA. Pdickson@ucla.edu
FAU - Pariser, A R
AU  - Pariser AR
FAU - Groft, S C
AU  - Groft SC
FAU - Ishihara, R W
AU  - Ishihara RW
FAU - McNeil, D E
AU  - McNeil DE
FAU - Tagle, D
AU  - Tagle D
FAU - Griebel, D J
AU  - Griebel DJ
FAU - Kaler, S G
AU  - Kaler SG
FAU - Mink, J W
AU  - Mink JW
FAU - Shapiro, E G
AU  - Shapiro EG
FAU - Bjoraker, K J
AU  - Bjoraker KJ
FAU - Krivitzky, L
AU  - Krivitzky L
FAU - Provenzale, J M
AU  - Provenzale JM
FAU - Gropman, A
AU  - Gropman A
FAU - Orchard, P
AU  - Orchard P
FAU - Raymond, G
AU  - Raymond G
FAU - Cohen, B H
AU  - Cohen BH
FAU - Steiner, R D
AU  - Steiner RD
FAU - Goldkind, S F
AU  - Goldkind SF
FAU - Nelson, R M
AU  - Nelson RM
FAU - Kakkis, E
AU  - Kakkis E
FAU - Patterson, M C
AU  - Patterson MC
LA  - eng
GR  - HD057136/HD/NICHD NIH HHS/United States
GR  - R01 FD003450/FD/FDA HHS/United States
GR  - R01 HD057136/HD/NICHD NIH HHS/United States
GR  - U54 NS065768/NS/NINDS NIH HHS/United States
GR  - ZIA HD008768-07/Intramural NIH HHS/United States
GR  - U54 HD061221/HD/NICHD NIH HHS/United States
GR  - R01 HD057136-03/HD/NICHD NIH HHS/United States
GR  - R01 NS060022/NS/NINDS NIH HHS/United States
GR  - U54 HD061221-08/HD/NICHD NIH HHS/United States
GR  - U54 NS065768-02/NS/NINDS NIH HHS/United States
GR  - U54 RR019453-05/RR/NCRR NIH HHS/United States
GR  - NS054242/NS/NINDS NIH HHS/United States
GR  - R01 NS054242-05/NS/NINDS NIH HHS/United States
GR  - R01 NS060022-04/NS/NINDS NIH HHS/United States
GR  - RR019453/RR/NCRR NIH HHS/United States
GR  - R01NS060022/NS/NINDS NIH HHS/United States
GR  - R01 NS054242/NS/NINDS NIH HHS/United States
GR  - NS065768-01/NS/NINDS NIH HHS/United States
GR  - U54 RR019453/RR/NCRR NIH HHS/United States
GR  - M01 RR000425/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20101202
PL  - United States
TA  - Mol Genet Metab
JT  - Molecular genetics and metabolism
JID - 9805456
SB  - IM
MH  - Animals
MH  - *Biomedical Research/ethics/trends
MH  - *Central Nervous System/pathology
MH  - Clinical Trials as Topic/ethics
MH  - Humans
MH  - Metabolism, Inborn Errors/*diagnosis/physiopathology/*therapy
MH  - Rare Diseases/therapy
PMC - PMC3040279
MID - NIHMS256937
EDAT- 2010/12/24 06:00
MHDA- 2011/06/07 06:00
CRDT- 2010/12/24 06:00
PHST- 2010/10/04 00:00 [received]
PHST- 2010/11/21 00:00 [revised]
PHST- 2010/11/21 00:00 [accepted]
PHST- 2010/12/24 06:00 [entrez]
PHST- 2010/12/24 06:00 [pubmed]
PHST- 2011/06/07 06:00 [medline]
AID - S1096-7192(10)00557-3 [pii]
AID - 10.1016/j.ymgme.2010.11.164 [doi]
PST - ppublish
SO  - Mol Genet Metab. 2011 Mar;102(3):326-38. doi: 10.1016/j.ymgme.2010.11.164. Epub
      2010 Dec 2.


PMID- 21176762
OWN - NLM
STAT- MEDLINE
DCOM- 20130103
LR  - 20151119
IS  - 0040-5957 (Print)
IS  - 0040-5957 (Linking)
VI  - 65
IP  - 6
DP  - 2010 Nov-Dec
TI  - [Ethical quality of nursing care in Lebanon].
PG  - 551-65
AB  - OBJECTIVE: The objective was to reflect on the nurse's role and on the
      determinants of a responsible choice. In order to do it, we tried to answer the
      following questions: (1) Are the role and the mission of the nursing body well
      acquired in Lebanon? (2) Are there international and national norms which govern 
      the accomplishment of this mission? (3) At what point does the mission
      accomplished by the nursing body procure the patient's safety? (4) What are the
      factors that modify the performance of the nursing body in Lebanon? And, (5) What
      are the challenges of a good-quality nursing performance? METHODS: We conducted a
      double arm survey. The first one is made on 160 nurses working in 19 hospitals
      that succeeded to establish until July 2008 (end of study) at least an ethical
      committee for medical care. The second one was conducted on the heads of the
      nursing departments in 49 private institutes, 34 public institutes and 16
      universities. RESULTS AND DISCUSSION: The investigated nurses don't know very
      well the medical and nursing ethics' principles that are very well highlighted in
      the Husted decisional model and expressed by justice, autonomy, confidentiality, 
      beneficience, veracity and fidelity. This result underlines a fact that affects
      the nurse's mission and so on the patients' safety. Ninety-four per cent of the
      nurses think that the education and the communication with the patient is not a
      priority during their daily work, which hinders the three essential times
      (analysis, communication and assessment) required to elaborate a freely informed 
      decision. Ethics don't have a solid basis in education. CONCLUSION: We must be
      concerned by this diagnostic, but it leads to the hope of being able to find
      together, through a common reflection, the essential characteristics to assume
      our responsibilities whether in the medical or nursing domain.
CI  - (c) 2010 Societe Francaise de Pharmacologie et de Therapeutique.
FAU - Abou-Mrad, Fadi
AU  - Abou-Mrad F
AD  - Service de Neurologie, Hopital Saint Charles, Fayadieh, Liban.
      faboumrad@ul.edu.lb
FAU - Atallah, Christine
AU  - Atallah C
FAU - Antoun, Nathalie
AU  - Antoun N
FAU - Kerbage, Mireille
AU  - Kerbage M
FAU - Melhem, Georges
AU  - Melhem G
FAU - Hanna, Lara
AU  - Hanna L
FAU - Stephan, Nada
AU  - Stephan N
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Qualite ethique de l'exercice de la profession d'infirmier au Liban.
DEP - 20101223
PL  - France
TA  - Therapie
JT  - Therapie
JID - 0420544
SB  - IM
MH  - Adult
MH  - Attitude of Health Personnel
MH  - *Ethics, Nursing
MH  - Female
MH  - Health Care Surveys
MH  - Humans
MH  - Lebanon/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Morals
MH  - Nurses
MH  - Nursing Care/*ethics/*standards
MH  - Patient Safety
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2010/12/24 06:00
MHDA- 2013/01/04 06:00
CRDT- 2010/12/24 06:00
PHST- 2010/03/29 00:00 [received]
PHST- 2010/10/04 00:00 [accepted]
PHST- 2010/12/24 06:00 [entrez]
PHST- 2010/12/24 06:00 [pubmed]
PHST- 2013/01/04 06:00 [medline]
AID - 10.2515/therapie/2010078 [doi]
AID - th101883 [pii]
PST - ppublish
SO  - Therapie. 2010 Nov-Dec;65(6):551-65. doi: 10.2515/therapie/2010078. Epub 2010 Dec
      23.


PMID- 21176605
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20101223
IS  - 0412-4081 (Print)
IS  - 0412-4081 (Linking)
VI  - 46
IP  - 10
DP  - 2010 Oct
TI  - [To expand the grand prospect of Chinese Journal of Ophthalmology following the
      fine tradition].
PG  - 877-9
AB  - When we celebrate the diamond jubilee of Chinese Journal of Ophthalmology (CJO), 
      we also reviewed its past and prospected its future. Under the effort by the
      editorial members and the great majority of ophthalmologists for sixty years, CJO
      has become the most authoritative and academic journal in ophthalmology in China,
      and has formed the fine tradition of "to respect the profession, to believe the
      truth and to advance bravely". At present, CJO has a basis to further become the 
      most authoritative academic journal in ophthalmology not only in the domestic but
      also in the world. For realizing the grand prospect, we should do more arduous
      effort for facing the all kind of the challenges in our ways forward; we should
      let the editorial committee to play the full role in our work; we should continue
      to raise the professional level of all editorial personnel; we should make great 
      efforts to find and edit more and more articles with the high quality; we should 
      observe the morals and ethics for editorial personnel; we should hear and accept 
      the opinions, suggestions and criticisms; we should strength the international
      cooperation and communication.
FAU - Zhao, Jia-liang
AU  - Zhao JL
AD  - Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union 
      Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
      zhaojialiang@medmail.com.cn
FAU - Zhao, Kan-xing
AU  - Zhao KX
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Yan Ke Za Zhi
JT  - [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
JID - 16210540R
SB  - IM
MH  - *Ophthalmology
MH  - *Periodicals as Topic
EDAT- 2010/12/24 06:00
MHDA- 2011/11/16 06:00
CRDT- 2010/12/24 06:00
PHST- 2010/12/24 06:00 [entrez]
PHST- 2010/12/24 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yan Ke Za Zhi. 2010 Oct;46(10):877-9.


PMID- 21176481
OWN - NLM
STAT- MEDLINE
DCOM- 20111103
LR  - 20160607
IS  - 0578-1310 (Print)
IS  - 0578-1310 (Linking)
VI  - 48
IP  - 10
DP  - 2010 Oct
TI  - [Molecular epidemiological and clinical features of coronavirus HKU1 in children 
      with acute respiratory tract infection in Lanzhou].
PG  - 744-7
AB  - OBJECTIVE: Human coronavirus (CoV)-HKU1 (HCoV-HKU1) was first isolated by Woo et 
      al in Hong Kong. Several successive reports confirmed retrospectively that this
      new human coronavirus was circulating in different countries worldwide. However, 
      the impact and the role of the emerging HCoV-HKU1 were not defined in children
      with ARTI. The objective of this study was to investigate the molecular
      epidemiology and clinical characteristics of HCoV-HKU1 infection in children with
      ARTI in Lanzhou, China. METHOD: Nasopharyngeal aspiration (NPA) samples were
      collected from 301 children with ARTI at the First Hospital of Lanzhou
      University, Gansu Province, China, between November 2007 and October 2008.
      Demographic data and clinical findings of these children were collected at the
      same time. The informed consent was obtained from their parents. This study
      protocol was approved by the hospital ethics committee. The reverse transcription
      polymerase chain reaction (RT-PCR) was employed to screen HCoV-HKU1. Furthermore,
      other common respiratory viruses were screened in HCoV-HKU1 positive samples. All
      PCR positive products were sequenced, and phylogenetic analysis was conducted.
      RESULT: The overall frequency of HCoV-HKU1 infection was 5.0% (15/301). The
      HCoV-HKU1 pol gene sequences shared a 95.8% - 99.6% nucleotide identity with the 
      human coronavirus-HKU1 strain, whereas the amino acid identity was 90.7% - 99.3%.
      The phylogenetic analysis revealed that the HCoV-HKU1 strain pol gene clustered
      with the HCoV-HKU1 strain N15 genotype B (no. DQ415911); 11 of 15 HCoV-HKU1
      positive sample tested were mixed-infection. HCoV-HKU1 was detected only from
      November to April. Positive specimens peaked in November. Children with HCoV-HKU1
      infection varied in age from 15 day to 12-years (median age, 10 months). The
      clinical diagnoses of HCoV-HKU1 positive patients included those with AURI and
      LURI. The clinical presentations of HCoV-HKU1 positive children included fever,
      cough, sputum production, diarrhea, vomiting; pharynx engorgement, crackles, and 
      wheezing. The mean hospital stay of the 14 patients was 9.9 days. Six of 15
      HCoV-HKU1 positive patients had an underlying illness, and they were all
      inpatients (hospital stay, mean, 11.2 days). There was no statistically
      significant difference in the detection rate between the two groups with and
      without underlying illnesses. CONCLUSION: Human CoV-HKU1 infection exists in
      children with respiratory tract infections in Lanzhou region. A single HCoV-HKU1 
      genotype B was circulating locally. The symptoms and clinical diagnoses of those 
      infected with HCoV-HKU1 had no specificity as compared with patients with other
      common respiratory viruses infection.
FAU - Song, Jing-rong
AU  - Song JR
AD  - Department of Pediatrics, First Hospital, Lanzhou University, Lanzhou 730000,
      China.
FAU - Jin, Yu
AU  - Jin Y
FAU - Duan, Zhao-jun
AU  - Duan ZJ
FAU - Yuan, Xin-hui
AU  - Yuan XH
FAU - Yan, Kun-long
AU  - Yan KL
FAU - Zhao, Yang
AU  - Zhao Y
FAU - Xie, Zhi-ping
AU  - Xie ZP
FAU - Gao, Han-chun
AU  - Gao HC
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Er Ke Za Zhi
JT  - Zhonghua er ke za zhi = Chinese journal of pediatrics
JID - 0417427
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - China/epidemiology
MH  - Coronavirus/classification/genetics/*isolation & purification
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Molecular Epidemiology
MH  - Respiratory Tract Infections/*epidemiology/*virology
EDAT- 2010/12/24 06:00
MHDA- 2011/11/04 06:00
CRDT- 2010/12/24 06:00
PHST- 2010/12/24 06:00 [entrez]
PHST- 2010/12/24 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
PST - ppublish
SO  - Zhonghua Er Ke Za Zhi. 2010 Oct;48(10):744-7.


PMID- 21176130
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110124
LR  - 20211020
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 11
DP  - 2010 Dec 21
TI  - Retraction: End-of-life discontinuation of destination therapy with cardiac and
      ventilatory support medical devices: physician-assisted death or allowing the
      patient to die? BMC Medical Ethics 2010, 11:15.
PG  - 20
LID - 10.1186/1472-6939-11-20 [doi]
LA  - eng
PT  - Retraction of Publication
DEP - 20101221
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
ROF - Rady MY, Verheijde JL. BMC Med Ethics. 2010;11:15. PMID: 20843327
PMC - PMC3017057
EDAT- 2010/12/24 06:00
MHDA- 2011/01/25 06:00
CRDT- 2010/12/24 06:00
PHST- 2010/12/16 00:00 [received]
PHST- 2010/12/21 00:00 [accepted]
PHST- 2010/12/24 06:00 [entrez]
PHST- 2010/12/24 06:00 [pubmed]
PHST- 2011/01/25 06:00 [medline]
AID - 1472-6939-11-20 [pii]
AID - 10.1186/1472-6939-11-20 [doi]
PST - epublish
SO  - BMC Med Ethics. 2010 Dec 21;11:20. doi: 10.1186/1472-6939-11-20.


PMID- 21175736
OWN - NLM
STAT- MEDLINE
DCOM- 20111014
LR  - 20110708
IS  - 1365-2842 (Electronic)
IS  - 0305-182X (Linking)
VI  - 38
IP  - 8
DP  - 2011 Aug
TI  - Designing cobalt chromium removable partial dentures for patients with shortened 
      dental arches: a pilot survey.
PG  - 608-14
LID - 10.1111/j.1365-2842.2010.02190.x [doi]
AB  - The aim of this survey was to investigate the quality of prescription for the
      fabrication of cobalt chromium removable partial dentures (RPDs) that are used to
      extend the shortened dental arches (SDAs). A survey of four commercial dental
      laboratories located in northern England was conducted. The target of this survey
      was cobalt chromium RPDs that were requested to restore SDAs comprising the
      anterior teeth and 2-4 premolars. Dentists' prescriptions were scrutinised, and a
      special data collection form was completed accordingly. A total of 94 dentists'
      prescriptions and associated SDA casts were examined. Almost all the requested
      cobalt chromium RPDs were clasp-retained RPDs (97%). Scrutinising the 91
      prescriptions for clasp-retained cobalt chromium RPDs showed that dentists'
      prescriptions did not have any instructions about the design of the partial
      denture in a considerable proportion of the cases (32%). Teeth to be clasped were
      identified clearly in 45% of the prescriptions. A majority of the dentists (64%) 
      failed to provide any instructions about the design of the rests to be placed on 
      the most posterior premolar abutment teeth. A considerable proportion of the
      dentists delegated the task of selecting the type of the major connector to the
      dental technician (41%). Only 21 (23%) of the examined casts had clearly defined 
      rest seat preparation. The outcome of this pilot survey shows inadequate quality 
      of prescription in designing RPDs for patients with SDAs. This finding has an
      ethical and clinical bearing and does not fit with current legal guidelines
      relevant to designing RPDs.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Nassani, M Z
AU  - Nassani MZ
AD  - University of Aleppo, Syria. mznassani@hotmail.com
FAU - Devlin, H
AU  - Devlin H
FAU - Tarakji, B
AU  - Tarakji B
FAU - McCord, J F
AU  - McCord JF
LA  - eng
PT  - Journal Article
DEP - 20101222
PL  - England
TA  - J Oral Rehabil
JT  - Journal of oral rehabilitation
JID - 0433604
RN  - 0 (Chromium Alloys)
SB  - IM
MH  - *Chromium Alloys
MH  - Dental Arch/*abnormalities
MH  - Denture Design/*standards
MH  - Denture, Partial, Removable/*standards
MH  - England
MH  - Female
MH  - General Practice, Dental
MH  - Humans
MH  - Male
MH  - Pilot Projects
EDAT- 2010/12/24 06:00
MHDA- 2011/10/15 06:00
CRDT- 2010/12/24 06:00
PHST- 2010/12/24 06:00 [entrez]
PHST- 2010/12/24 06:00 [pubmed]
PHST- 2011/10/15 06:00 [medline]
AID - 10.1111/j.1365-2842.2010.02190.x [doi]
PST - ppublish
SO  - J Oral Rehabil. 2011 Aug;38(8):608-14. doi: 10.1111/j.1365-2842.2010.02190.x.
      Epub 2010 Dec 22.


PMID- 21175716
OWN - NLM
STAT- MEDLINE
DCOM- 20111013
LR  - 20110617
IS  - 1539-6924 (Electronic)
IS  - 0272-4332 (Linking)
VI  - 31
IP  - 6
DP  - 2011 Jun
TI  - Evaluation of legal liability for technological risks in view of requirements for
      peaceful coexistence and progress.
PG  - 969-83
LID - 10.1111/j.1539-6924.2010.01545.x [doi]
AB  - Legal liability for risk-generating technological activities is evaluated in view
      of requirements that are necessary for peaceful human coexistence and progress in
      order to show possibilities for improvement. The requirements imply, given that
      political decision making about the activities proceeds on the basis of majority 
      rule, that legal liability should be unconditional (absolute, strict) and
      unlimited (full). We analyze actual liability in international law for various
      risk-generating technological activities, to conclude that nowhere is the
      standard of unconditional and unlimited liability fully met. Apart from that
      there are enormous differences. Although significant international liability
      legislation is in place for some risk-generating technological activities,
      legislation is virtually absent for others. We discuss fundamental possibilities 
      and limitations of liability and private insurance to secure credible and
      ethically sound risk assessment and risk management practices. The limitations
      stem from problems of establishing a causal link between an activity and a harm; 
      compensating irreparable harm; financial warranty; moral hazard in insurance and 
      in organizations; and discounting future damage to present value. As our
      requirements call for prior agreement among all who are subjected to the risks of
      an activity about the settlement of these difficult problems, precautionary ex
      ante regulation of risk-generating activities may be a more attractive option,
      either combined with liability stipulations or not. However, if ex ante
      regulation is not based on the consent of all subjected to the risks, it remains 
      that the basis of liability in the law should be unconditional and unlimited
      liability.
CI  - (c) 2010 Society for Risk Analysis.
FAU - Zandvoort, Henk
AU  - Zandvoort H
AD  - Faculty of Technology, Policy and Management, Delft University of Technology, The
      Netherlands. h.zandvoort@tudelft.nl
LA  - eng
PT  - Journal Article
DEP - 20101222
PL  - United States
TA  - Risk Anal
JT  - Risk analysis : an official publication of the Society for Risk Analysis
JID - 8109978
SB  - IM
MH  - Decision Making, Organizational
MH  - Humans
MH  - *Liability, Legal
MH  - Politics
MH  - Risk Assessment
EDAT- 2010/12/24 06:00
MHDA- 2011/10/14 06:00
CRDT- 2010/12/24 06:00
PHST- 2010/12/24 06:00 [entrez]
PHST- 2010/12/24 06:00 [pubmed]
PHST- 2011/10/14 06:00 [medline]
AID - 10.1111/j.1539-6924.2010.01545.x [doi]
PST - ppublish
SO  - Risk Anal. 2011 Jun;31(6):969-83. doi: 10.1111/j.1539-6924.2010.01545.x. Epub
      2010 Dec 22.


PMID- 21175190
OWN - NLM
STAT- MEDLINE
DCOM- 20110504
LR  - 20110119
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 59
IP  - 2
DP  - 2011 Jan 26
TI  - High level of mislabeling in Spanish and Greek hake markets suggests the
      fraudulent introduction of African species.
PG  - 475-80
LID - 10.1021/jf103754r [doi]
AB  - DNA analysis of hake products commercialized in southern European (Spanish and
      Greek) market chains have demonstrated more than 30% mislabeling, on the basis of
      species substitution. Tails and fillets were more mislabeled than other products,
      such as slices and whole pieces. African species were substitute species for
      products labeled as American and European species, and we suggest it is a case of
      deliberate economically profitable mislabeling because real market prices of
      European and American hake products are higher than those of African in Spanish
      market chains. The presented results suggest fraud detection that disadvantages
      African producers. Government-mandated genetic surveys of commercial hakes and
      the use of subsequent statements of fair trade on labels of seafood products
      could help to reduce fraud levels in a global market of increasingly conscious
      consumers sensitive to ethical issues.
FAU - Garcia-Vazquez, Eva
AU  - Garcia-Vazquez E
AD  - Departamento de Biologia Funcional, Universidad de Oviedo, 33006 Oviedo, Spain.
      egv@uniovi.es
FAU - Perez, Juliana
AU  - Perez J
FAU - Martinez, Jose L
AU  - Martinez JL
FAU - Pardinas, Antonio F
AU  - Pardinas AF
FAU - Lopez, Belen
AU  - Lopez B
FAU - Karaiskou, Nikoletta
AU  - Karaiskou N
FAU - Casa, Mary F
AU  - Casa MF
FAU - Machado-Schiaffino, Gonzalo
AU  - Machado-Schiaffino G
FAU - Triantafyllidis, Alexander
AU  - Triantafyllidis A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101222
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
SB  - IM
MH  - Africa
MH  - Animals
MH  - Consumer Product Safety
MH  - Europe
MH  - Food Contamination/analysis
MH  - *Food Labeling/standards
MH  - Gadiformes/classification/*genetics
MH  - Quality Control
MH  - Seafood/*analysis/standards
EDAT- 2010/12/24 06:00
MHDA- 2011/05/05 06:00
CRDT- 2010/12/24 06:00
PHST- 2010/12/24 06:00 [entrez]
PHST- 2010/12/24 06:00 [pubmed]
PHST- 2011/05/05 06:00 [medline]
AID - 10.1021/jf103754r [doi]
PST - ppublish
SO  - J Agric Food Chem. 2011 Jan 26;59(2):475-80. doi: 10.1021/jf103754r. Epub 2010
      Dec 22.


PMID- 21174684
OWN - NLM
STAT- MEDLINE
DCOM- 20110120
LR  - 20110727
IS  - 0047-1852 (Print)
IS  - 0047-1852 (Linking)
VI  - 68
IP  - 12
DP  - 2010 Dec
TI  - [Japanese ethos and organ transplantation from brain-dead donors].
PG  - 2234-8
AB  - A trend observed since the 1980s in the Japanese academic scene is the
      overturning of Hippocratic ethics by American individualistic bioethics. However,
      the Japanese ethos is more sympathetic to personalistic bioethics rooted in
      Hippocratic ethics, which assumes the universal view of the 'interdependent self'
      clearly marked off from the 'independent self' specific to American culture. In
      Japan, organ transplantation from brain-dead donors is promoted despite the lack 
      of consensus on whether brain death signifies death of the individual. From the
      viewpoint of personalistic bioethics, this situation is problematic because it
      violates the dictum primum non nocere of the Hippocratic Oath. We should
      therefore first establish consensus on brain death and then promote a 'culture of
      donation' based on human dignity.
FAU - Akiba, Etsuko
AU  - Akiba E
AD  - Department of Business Law, Faculty of Economy, University of Toyama.
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Nihon Rinsho
JT  - Nihon rinsho. Japanese journal of clinical medicine
JID - 0420546
SB  - IM
MH  - Bioethics
MH  - *Brain Death
MH  - *Ethics, Medical
MH  - Japan
MH  - *Organ Transplantation
EDAT- 2010/12/24 06:00
MHDA- 2011/01/21 06:00
CRDT- 2010/12/24 06:00
PHST- 2010/12/24 06:00 [entrez]
PHST- 2010/12/24 06:00 [pubmed]
PHST- 2011/01/21 06:00 [medline]
PST - ppublish
SO  - Nihon Rinsho. 2010 Dec;68(12):2234-8.


PMID- 21174650
OWN - NLM
STAT- MEDLINE
DCOM- 20110131
LR  - 20130520
IS  - 0035-3639 (Print)
IS  - 0035-3639 (Linking)
VI  - 31
IP  - 5
DP  - 2010 Sep-Oct
TI  - [Legislative frame and clinical trials in Lebanon].
PG  - 467-73
AB  - UNLABELLED: In Lebanon, as in other developing countries, most of the clinical
      trials are achieved without considering any rule adopted in the industrialized
      countries, which causes serious ethical problems. This study aims to review the
      different Lebanese texts related to clinical trials in order to show the existing
      legislative frame, and to formulate suggestions that help the legislator defining
      better this activity. We reviewed and analyzed the Lebanese legislation related
      to the clinical trials especially the Lebanese law project about "therapeutic
      trials on human subjects" and conducted semi-directive interviews with actors
      from the society. RESULTS: We noticed a legislative gap in this domain,
      highlighting the fragility of the social link in the health domain, and
      reverberating negatively on the physician/physician, physician/hospital,
      physician/industrial and industrial/hospital relationships, in addition to many
      gaps affecting the skills of physicians-investigators. In spite of the promising 
      institutional effort, the national frame of clinical trials does not seem to be
      sufficient regarding the ignorance of applied legislative texts, the industrial
      promoter's weight, and the pressures. This is applied to the absence of a
      powerful national coordinator, the inexistence of a pharmacovigilance system or a
      skillful authority for the sanitary security of health products, and the
      confusion in the concepts of medical ethics and deontology. In conclusion were
      presented for achieving improvements on many levels: an objective criticism of
      the law project proposed in 2002 followed by a call to review its content and
      improve it in order to reach an instructive and applicable global legislation ;
      an action that can be realized only through educating adequately the
      investigators, and informing the large public in order to guide the governors
      towards a legislation allowing people in Lebanon to "live well " with complete
      dignity.
FAU - Abou-Mrad, F
AU  - Abou-Mrad F
AD  - Service de Neurologie, Hopital Saint Charles, Fayadieh, Faculte des Sciences
      medicales, Universite Libanaise, Liban. faboumrad@ul.edu.lb
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Le cadre legislatif des essais cliniques au Liban.
PL  - Belgium
TA  - Rev Med Brux
JT  - Revue medicale de Bruxelles
JID - 8003474
SB  - IM
MH  - Clinical Trials as Topic/*legislation & jurisprudence
MH  - Humans
MH  - Lebanon
EDAT- 2010/12/24 06:00
MHDA- 2011/02/01 06:00
CRDT- 2010/12/24 06:00
PHST- 2010/12/24 06:00 [entrez]
PHST- 2010/12/24 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
PST - ppublish
SO  - Rev Med Brux. 2010 Sep-Oct;31(5):467-73.


PMID- 21174047
OWN - NLM
STAT- MEDLINE
DCOM- 20140723
LR  - 20101221
IS  - 1945-404X (Electronic)
IS  - 0090-7421 (Linking)
VI  - 39 Suppl 1
DP  - 2010 Fall
TI  - Interprofessional ethics in rehabilitation: the dreamcatcher journey.
PG  - 246-50
AB  - In 2003, we led a working conference on leadership in ethics education for
      physical therapy and occupational therapy entitled, "Dreamcatchers and the Common
      Good: Allied Health Leadership in Generational Health and Ethics." The institute 
      brought together 25 leaders in ethics education in physical therapy and
      occupational therapy for a 3-day working conference of experts. In this paper, we
      discuss our work as part of an interdisciplinary community of ethics educators
      who have been grappling with ethics education in rehabilitation over the last 7
      years. We reflect on our collaborative work and then propose components of a
      moral foundation required for continued interprofessional dialogue and work.
FAU - Jensen, Gail M
AU  - Jensen GM
AD  - Graduate School and Associate Vice President, Academic Affairs, 2500 California
      Plaza, Creighton Hall Rm 132, Creighton University, Omaha, NE 68178, USA. Tel
      402-280-3727, fax 402-280-2899. GailJensen@creighton.edu.
FAU - Royeen, Charlotte Brasic
AU  - Royeen CB
FAU - Purtilo, Ruth B
AU  - Purtilo RB
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Allied Health
JT  - Journal of allied health
JID - 0361603
SB  - IM
MH  - Congresses as Topic
MH  - Cooperative Behavior
MH  - *Ethics, Professional
MH  - Humans
MH  - *Interdisciplinary Studies
MH  - Occupational Therapy/*education/*ethics
MH  - Physical Therapists/*education/*ethics
MH  - United States
EDAT- 2010/12/22 06:00
MHDA- 2014/07/24 06:00
CRDT- 2010/12/22 06:00
PHST- 2010/12/22 06:00 [entrez]
PHST- 2010/12/22 06:00 [pubmed]
PHST- 2014/07/24 06:00 [medline]
PST - ppublish
SO  - J Allied Health. 2010 Fall;39 Suppl 1:246-50.


PMID- 21172060
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1742-4933 (Electronic)
IS  - 1742-4933 (Linking)
VI  - 7 Suppl 1
DP  - 2010 Dec 16
TI  - Predictive diagnostics and personalized medicine for the prevention of chronic
      degenerative diseases.
PG  - S1
LID - 10.1186/1742-4933-7-S1-S1 [doi]
AB  - Progressive increase of mean age and life expectancy in both industrialized and
      emerging societies parallels an increment of chronic degenerative diseases (CDD) 
      such as cancer, cardiovascular, autoimmune or neurodegenerative diseases among
      the elderly. CDD are of complex diagnosis, difficult to treat and absorbing an
      increasing proportion in the health care budgets worldwide. However, recent
      development in modern medicine especially in genetics, proteomics, and
      informatics is leading to the discovery of biomarkers associated with different
      CDD that can be used as indicator of disease's risk in healthy subjects.
      Therefore, predictive medicine is merging and medical doctors may for the first
      time anticipate the deleterious effect of CDD and use markers to identify persons
      with high risk of developing a given CDD before the clinical manifestation of the
      diseases. This innovative approach may offer substantial advantages, since the
      promise of personalized medicine is to preserve individual health in people with 
      high risk by starting early treatment or prevention protocols. The pathway is now
      open, however the road to an effective personalized medicine is still long,
      several (diagnostic) predictive instruments for different CDD are under
      development, some ethical issues have to be solved. Operative proposals for the
      heath care systems are now needed to verify potential benefits of predictive
      medicine in the clinical practice. In fact, predictive diagnostics, personalized 
      medicine and personalized therapy have the potential of changing classical
      approaches of modern medicine to CDD.
FAU - Licastro, Federico
AU  - Licastro F
AD  - Department of Experimental Pathology, University of Bologna, Via San Giacomo 14, 
      40126, Bologna, Italy. federico.licastro@unibo.it.
FAU - Caruso, Calogero
AU  - Caruso C
LA  - eng
PT  - Journal Article
DEP - 20101216
PL  - England
TA  - Immun Ageing
JT  - Immunity & ageing : I & A
JID - 101235427
PMC - PMC3024875
EDAT- 2010/12/22 06:00
MHDA- 2010/12/22 06:01
CRDT- 2010/12/22 06:00
PHST- 2010/12/22 06:00 [entrez]
PHST- 2010/12/22 06:00 [pubmed]
PHST- 2010/12/22 06:01 [medline]
AID - 1742-4933-7-S1-S1 [pii]
AID - 10.1186/1742-4933-7-S1-S1 [doi]
PST - epublish
SO  - Immun Ageing. 2010 Dec 16;7 Suppl 1:S1. doi: 10.1186/1742-4933-7-S1-S1.


PMID- 21172003
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20211020
IS  - 1466-609X (Electronic)
IS  - 1364-8535 (Linking)
VI  - 14
IP  - 6
DP  - 2010
TI  - End-of-life decisions in Greek intensive care units: a multicenter cohort study.
PG  - R228
LID - 10.1186/cc9380 [doi]
AB  - INTRODUCTION: Intensive care may prolong the dying process in patients who have
      been unresponsive to the treatment already provided. Limitation of
      life-sustaining therapy, by either withholding or withdrawing support, is an
      ethically acceptable and common worldwide practice. The purpose of the present
      study was to examine the frequency, types, and rationale of limiting life support
      in Greek intensive care units (ICUs), the clinical and demographic parameters
      associated with it, and the participation of relatives in decision making.
      METHODS: This was a prospective observational study conducted in eight Greek
      multidisciplinary ICUs. We studied all consecutive ICU patients who died,
      excluding those who stayed in the ICU less than 48 hours or were brain dead.
      RESULTS: Three hundred six patients composed the study population, with a mean
      age of 64 years and a mean APACHE II score on admission of 21. Of study patients,
      41% received full support, including unsuccessful cardiopulmonary resuscitation
      (CPR); 48% died after withholding of CPR; 8%, after withholding of other
      treatment modalities besides CPR; and 3%, after withdrawal of treatment. Patients
      in whom therapy was limited had a longer ICU (P < 0.01) and hospital (P = 0.01)
      length of stay, a lower Glasgow Coma Scale score (GCS) on admission (P < 0.01), a
      higher APACHE II score 24 hours before death (P < 0.01), and were more likely to 
      be admitted with a neurologic diagnosis (P < 0.01). Patients who received full
      support were more likely to be admitted with either a cardiovascular (P = 0.02)
      or trauma diagnosis (P = 0.05) and to be surgical rather than medical (P = 0.05).
      The main factors that influenced the physician's decision were, when providing
      full support, reversibility of illness and prognostic uncertainty, whereas, when 
      limiting therapy, unresponsiveness to treatment already offered, prognosis of
      underlying chronic disease, and prognosis of acute disorder. Relatives'
      participation in decision making occurred in 20% of cases and was more frequent
      when a decision to provide full support was made (P < 0.01). Advance directives
      were rare (1%). CONCLUSIONS: Limitation of life-sustaining treatment is a common 
      phenomenon in the Greek ICUs studied. However, in a large majority of cases, it
      is equivalent to the withholding of CPR alone. Withholding of other therapies
      besides CPR and withdrawal of support are infrequent. Medical paternalism
      predominates in decision making.
FAU - Kranidiotis, Georgios
AU  - Kranidiotis G
AD  - First Critical Care Department, Evangelismos Hospital, National and Kapodistrian 
      University of Athens, 45-47 Ypsilantou Str, Athens, 10675, Greece.
FAU - Gerovasili, Vasiliki
AU  - Gerovasili V
FAU - Tasoulis, Athanasios
AU  - Tasoulis A
FAU - Tripodaki, Elli
AU  - Tripodaki E
FAU - Vasileiadis, Ioannis
AU  - Vasileiadis I
FAU - Magira, Eleni
AU  - Magira E
FAU - Markaki, Vasiliki
AU  - Markaki V
FAU - Routsi, Christina
AU  - Routsi C
FAU - Prekates, Athanasios
AU  - Prekates A
FAU - Kyprianou, Theodoros
AU  - Kyprianou T
FAU - Clouva-Molyvdas, Phyllis-Maria
AU  - Clouva-Molyvdas PM
FAU - Georgiadis, Georgios
AU  - Georgiadis G
FAU - Floros, Ioannis
AU  - Floros I
FAU - Karabinis, Andreas
AU  - Karabinis A
FAU - Nanas, Serafim
AU  - Nanas S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20101220
PL  - England
TA  - Crit Care
JT  - Critical care (London, England)
JID - 9801902
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cohort Studies
MH  - *Decision Making
MH  - Female
MH  - Greece/epidemiology
MH  - Humans
MH  - *Intensive Care Units
MH  - Life Support Care/*methods/psychology
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Surveys and Questionnaires
MH  - Terminal Care/*methods/psychology
MH  - *Withholding Treatment
PMC - PMC3219993
EDAT- 2010/12/22 06:00
MHDA- 2012/01/27 06:00
CRDT- 2010/12/22 06:00
PHST- 2010/04/27 00:00 [received]
PHST- 2010/07/23 00:00 [revised]
PHST- 2010/12/20 00:00 [accepted]
PHST- 2010/12/22 06:00 [entrez]
PHST- 2010/12/22 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - cc9380 [pii]
AID - 10.1186/cc9380 [doi]
PST - ppublish
SO  - Crit Care. 2010;14(6):R228. doi: 10.1186/cc9380. Epub 2010 Dec 20.


PMID- 21171536
OWN - NLM
STAT- MEDLINE
DCOM- 20110203
LR  - 20190513
IS  - 0360-7283 (Print)
IS  - 0360-7283 (Linking)
VI  - 35
IP  - 4
DP  - 2010 Nov
TI  - Child health inequality: framing a social work response.
PG  - 291-301
AB  - Numerous studies acknowledge that the well-being of our nation hinges on the
      health of its people. There is specific concern about children because they
      represent the future. Ignoring children's health needs can compromise their
      educational preparedness, occupational pursuits, productivity, and longevity.
      Current science demonstrates that developmental, emotional, or behavioral
      limitations experienced during the early years of life and over the life course
      are associated with poor adult health outcomes. Poverty, restricted access to
      health insurance and health care services, cultural and linguistic barriers,
      neighborhood conditions, and racial and class inequalities exacerbate poor health
      outcomes and contribute to child health inequality. To respond to the
      complexities and threats of child health inequality, social workers must be
      sensitized to the physical and material constraints that support them and join
      forces with other disciplines in comprehensive approaches to reduce and prevent
      them. This article focuses on current knowledge about child health inequality and
      recommends how social workers can effect change in this area through practice,
      policy, and research that adheres to the profession's ethical principles and
      standards and promotes the public health.
FAU - Hernandez, Virginia Rondero
AU  - Hernandez VR
AD  - Department of Social Work Education, California State University, Fresno, CA
      93740, USA. virginiarh@csufresno.edu
FAU - Montana, Salvador
AU  - Montana S
FAU - Clarke, Kris
AU  - Clarke K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Health Soc Work
JT  - Health & social work
JID - 7611528
SB  - IM
MH  - Child
MH  - Child Welfare/*economics
MH  - Health Services Accessibility/economics/statistics & numerical data
MH  - *Health Status Disparities
MH  - Healthcare Disparities/*economics/statistics & numerical data
MH  - Humans
MH  - Infant
MH  - Infant Mortality
MH  - Medically Uninsured/statistics & numerical data
MH  - Obesity/economics
MH  - *Poverty
MH  - *Social Class
MH  - Social Work/methods/standards
MH  - Stress, Psychological/economics
MH  - United States/epidemiology
EDAT- 2010/12/22 06:00
MHDA- 2011/02/04 06:00
CRDT- 2010/12/22 06:00
PHST- 2010/12/22 06:00 [entrez]
PHST- 2010/12/22 06:00 [pubmed]
PHST- 2011/02/04 06:00 [medline]
AID - 10.1093/hsw/35.4.291 [doi]
PST - ppublish
SO  - Health Soc Work. 2010 Nov;35(4):291-301. doi: 10.1093/hsw/35.4.291.


PMID- 21147632
OWN - NLM
STAT- MEDLINE
DCOM- 20110225
LR  - 20211020
IS  - 0949-2321 (Print)
IS  - 0949-2321 (Linking)
VI  - 15 Suppl 2
DP  - 2010 Nov 4
TI  - Bioethics of life programs: taking seriously moral pluralism in clinical
      settings.
PG  - 98-101
AB  - BACKGROUND: In the more and more globalized world, the experience of moral
      pluralism (often related to, or based upon, religious pluralism) has become a
      common issue which ethical importance is undeniable. Potential conflicts between 
      patients' and therapeutic teams' moral views and between moral beliefs of the
      particular member of this team are being resolved in the light of bioethical
      theories, among which principlism remains the mainstream approach to biomedical
      ethics. The question arises, however, whether this approach, in itself, as being 
      strictly bound to the specific and distinct American philosophical tradition, is 
      to be considered the tool for so called ?moral imperialism'. Also architectures
      of principlism, in particular by elaborating the concept of common morality,
      defend the applicability of their theory to the pluralistic settings, it should
      be emphasized that the idea that some norms and standards of moral character are 
      shared by all morally serious people in every culture has attracted criticism
      both from empirical as well as theoretical backgrounds. OBJECTIVE: This paper
      aims at reconsidering principlism so that it would be more suitable for resolving
      moral dilemma in ethically pluralistic clinical settings. METHODS: Lakatos'
      sophisticated methodological falsification is used into two different ways: (1)
      to construct a concept of 'life programs' and (2) to confront a newly elaborated 
      ethical theory with principlism. The reflection is limited to the norms related
      to the key issue in clinical ethics, i.e., respecting the patient's autonomy.
      RESULTS: The concepts of common morality and particular moralities are
      interpreted (in the light of Lakatos' philosophy of sciences) as "hard core" and 
      "protective belt" of life programs, respectively. Accepting diversity of research
      programs, Lakatos maintains the idea of the objectivity of truth. Analogously,
      the plurality of life programs does not put into question the objectivity of
      moral values. The plurality of moral norms not only respects the objectivity of
      the good, but also can be seen as a condition sine qua non of such objectivity in
      the changing socio-historical context of doctor-patient relationship.
      CONCLUSIONS: The life program approach to bioethics and clinical ethics in
      particular, can be seen as a form of widening of principlism. This new approach, 
      being non-relativistic, is at the same time sensitive to moral pluralism
      experienced in everyday medical practice.
FAU - Niebroj, Leslaw
AU  - Niebroj L
AD  - Department of Philosophy and Pedagogy, Medical University of Silesia, Katowice,
      Poland. lniebroj@wp.pl
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur J Med Res
JT  - European journal of medical research
JID - 9517857
SB  - IM
MH  - *Bioethics
MH  - *Cultural Diversity
MH  - Humans
MH  - *Morals
MH  - *Principle-Based Ethics
PMC - PMC4360374
EDAT- 2010/12/22 06:00
MHDA- 2011/02/26 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/22 06:00 [pubmed]
PHST- 2011/02/26 06:00 [medline]
AID - 10.1186/2047-783x-15-s2-98 [doi]
PST - ppublish
SO  - Eur J Med Res. 2010 Nov 4;15 Suppl 2:98-101. doi: 10.1186/2047-783x-15-s2-98.


PMID- 21144083
OWN - NLM
STAT- MEDLINE
DCOM- 20110310
LR  - 20211020
IS  - 1475-2875 (Electronic)
IS  - 1475-2875 (Linking)
VI  - 9 Suppl 3
DP  - 2010 Dec 13
TI  - Health research ethics in malaria vector trials in Africa.
PG  - S3
LID - 10.1186/1475-2875-9-S3-S3 [doi]
AB  - Malaria mosquito research in Africa as elsewhere is just over a century old.
      Early trials for development of mosquito control tools were driven by colonial
      enterprises and war efforts; they were, therefore, tested in military or colonial
      settings. The failure of those tools and environmental concerns, coupled with the
      desperate need for integrated malaria control strategies, has necessitated the
      development of new malaria mosquito control tools, which are to be tested on
      humans, their environment and mosquito habitats. Ethical concerns start with
      phase 2 trials, which pose limited ethical dilemmas. Phase 3 trials, which are
      undertaken on vulnerable civilian populations, pose ethical dilemmas ranging from
      individual to community concerns. It is argued that such trials must abide by
      established ethical principles especially safety, which is mainly enshrined in
      the principle of non-maleficence. As there is total lack of experience with many 
      of the promising candidate tools (eg genetically modified mosquitoes,
      entomopathogenic fungi, and biocontrol agents), great caution must be exercised
      before they are introduced in the field. Since malaria vector trials, especially 
      phase 3 are intrusive and in large populations, individual and community respect 
      is mandatory, and must give great priority to community engagement. It is
      concluded that new tools must be safe, beneficial, efficacious, effective, and
      acceptable to large populations in the short and long-term, and that research
      benefits should be equitably distributed to all who bear the brunt of the
      research burdens. It is further concluded that individual and institutional
      capacity strengthening should be provided, in order to undertake essential
      research, carry out scientific and ethical review, and establish competent
      regulatory frameworks.
FAU - Kilama, Wen L
AU  - Kilama WL
AD  - African Malaria Network Trust, P O Box 33207 Dares Salaam, Tanzania.
      wlkilama@amanet-trust.org
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20101213
PL  - England
TA  - Malar J
JT  - Malaria journal
JID - 101139802
SB  - IM
MH  - Africa
MH  - Animals
MH  - Biomedical Research/*ethics
MH  - Clinical Trials, Phase II as Topic
MH  - Clinical Trials, Phase III as Topic
MH  - Culicidae/drug effects/growth & development/microbiology
MH  - *Disease Vectors
MH  - Humans
MH  - Malaria/*prevention & control/*transmission
MH  - Mosquito Control/*ethics/*methods
MH  - Pest Control, Biological/ethics/methods
PMC - PMC3002141
EDAT- 2010/12/22 06:00
MHDA- 2011/03/11 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/22 06:00 [pubmed]
PHST- 2011/03/11 06:00 [medline]
AID - 1475-2875-9-S3-S3 [pii]
AID - 10.1186/1475-2875-9-S3-S3 [doi]
PST - epublish
SO  - Malar J. 2010 Dec 13;9 Suppl 3:S3. doi: 10.1186/1475-2875-9-S3-S3.


PMID- 20943578
OWN - NLM
STAT- MEDLINE
DCOM- 20110217
LR  - 20101014
IS  - 0022-1465 (Print)
IS  - 0022-1465 (Linking)
VI  - 51 Suppl
DP  - 2010
TI  - Bioethics, raw and cooked: extraordinary conflict and everyday practice.
PG  - S133-46
LID - 10.1177/0022146510383839 [doi]
AB  - This article explains the emergence, growth, and institutional anchoring of
      bioethics in both policy and clinical arenas. Under the heading of principlism,
      bioethics developed a public language for resolving disputes that allowed it to
      transform disputes involving sacred matters into profane work routines. At the
      same time, having principlism as a common language for solving practical disputes
      allowed "ethics work" in health care to be separated from moral theorizing as a
      practical activity. Two issues--the right to die and the protection of research
      subjects--serve to illustrate the process through which bioethics established a
      large institutional footprint in health care.
FAU - Bosk, Charles L
AU  - Bosk CL
AD  - Department of Sociology, University of Pennsylvania, Philadelphia, PA 19104-6299,
      USA. cbosk@sas.upenn.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Health Soc Behav
JT  - Journal of health and social behavior
JID - 0103130
SB  - IM
MH  - *Bioethics
MH  - Culture
MH  - Dissent and Disputes
MH  - *Ethical Theory
MH  - Ethics, Research
MH  - Health Policy
MH  - Humans
MH  - Patient Rights
MH  - Social Problems
MH  - *Sociology, Medical
EDAT- 2010/12/22 06:00
MHDA- 2011/02/18 06:00
CRDT- 2010/10/15 06:00
PHST- 2010/10/15 06:00 [entrez]
PHST- 2010/12/22 06:00 [pubmed]
PHST- 2011/02/18 06:00 [medline]
AID - 51/1_suppl/S133 [pii]
AID - 10.1177/0022146510383839 [doi]
PST - ppublish
SO  - J Health Soc Behav. 2010;51 Suppl:S133-46. doi: 10.1177/0022146510383839.


PMID- 21170906
OWN - NLM
STAT- MEDLINE
DCOM- 20110531
LR  - 20220408
IS  - 1097-0258 (Electronic)
IS  - 0277-6715 (Linking)
VI  - 29
IP  - 30
DP  - 2010 Dec 30
TI  - An exact method for analysis following a two-stage phase II cancer clinical
      trial.
PG  - 3118-25
LID - 10.1002/sim.3837 [doi]
AB  - This paper presents an exact method for the analysis of a phase II cancer
      clinical trial conducted using a two-stage design in which early stopping may be 
      allowed for either futility or efficacy. The method provides a point and interval
      estimate of the response probability associated with the treatment under
      investigation and a p-value for testing whether this exceeds some standard null
      value. Two-stage designs are often used in phase II trials in oncology for
      reasons of ethics and efficiency, but this design feature is seldom taken into
      account when the results are analyzed. After any two-stage design or multi-stage 
      design, the method for analysis should take into account the previous interim
      analyses performed, otherwise the results will be biased. In this paper, an
      approximate approach based on a log-odds ratio parameterisation will be compared 
      with an exact method through the calculation of the precise coverage
      probabilities of each approach.
CI  - Copyright (c) 2010 John Wiley & Sons, Ltd.
FAU - Jovic, Gordana
AU  - Jovic G
AD  - Institute of Medical Statistics and Biometry, University of Milan, Italy.
      goj@ctu.mrc.ac.uk
FAU - Whitehead, John
AU  - Whitehead J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Stat Med
JT  - Statistics in medicine
JID - 8215016
SB  - IM
MH  - Clinical Trials, Phase II as Topic/*methods
MH  - *Data Interpretation, Statistical
MH  - Humans
MH  - Medical Oncology/methods
MH  - *Odds Ratio
MH  - *Research Design
EDAT- 2010/12/21 06:00
MHDA- 2011/06/01 06:00
CRDT- 2010/12/21 06:00
PHST- 2010/12/21 06:00 [entrez]
PHST- 2010/12/21 06:00 [pubmed]
PHST- 2011/06/01 06:00 [medline]
AID - 10.1002/sim.3837 [doi]
PST - ppublish
SO  - Stat Med. 2010 Dec 30;29(30):3118-25. doi: 10.1002/sim.3837.


PMID- 21170205
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130704
LR  - 20211020
IS  - 0974-925X (Electronic)
IS  - 0974-7788 (Linking)
VI  - 1
IP  - 3
DP  - 2010 Jul
TI  - Effects of Withania somnifera (Ashwagandha) and Terminalia arjuna (Arjuna) on
      physical performance and cardiorespiratory endurance in healthy young adults.
PG  - 144-9
LID - 10.4103/0974-7788.72485 [doi]
AB  - INTRODUCTION: Several medicinal plants have been described to be beneficial for
      cardiac ailments in Ayurveda like Ashwagandha and Arjuna. Ashwagandha-categorised
      as Rasayanas, and described to promote health and longevity and Arjuna primarily 
      for heart ailments. coronary artery disease, heart failure, hypercholesterolemia,
      anginal pain and can be considered as a useful drug for coronary artery disease, 
      hypertension and ischemic cardiomyopathy. OBJECTIVE: There are no scientific
      clinical studies showing effect of both these drugs on exercise performance after
      regular administration when given as supplements The present study was therefore 
      designed and performed to assess the effects of Withania somnifera (Ashwagandha) 
      and Terminalia arjuna (Arjuna) individually and as a combination on maximum
      velocity, average absolute and relative Power, balance, maximum oxygen
      consumption (VO2 max) and blood pressure in humans. MATERIALS AND METHODS: Forty 
      normal healthy. Subjects (either sex, mean age 20.6 +/- 2.5yrs and mean Body Mass
      Index 21.9 +/- 2.2) were recruited after written informed consent was obtained.
      Institutional Ethics Committee permission was also obtained. Thirty participants 
      were assigned to experimental group of which 10 received standardized root
      extracts of Withania somnifera, 10 received standardized bark extract of
      Terminalia arjuna and the rest of the 10 received standardized root extract of
      Withania somnifera in addition to bark extract of Terminalia arjuna both. Both
      the drugs were given in the form of capsules (dosage 500mg/day for both the
      drugs). Ten participants received placebo (capsules filled with flour). All the
      subjects continued the regimen for 8 weeks. All variables were assessed before
      and after the course of drug administration OBSERVATIONS: Our study showed that
      Withania somnifera increased velocity, power and VO2 max whereas Terminalia
      arjuna increased VO2 max and lowered resting systolic blood pressure. When given 
      in combination, the improvement was seen in all parameters except balance and
      diastolic blood pressure. CONCLUSION: Withania somnifera may therefore be useful 
      for generalized weakness and to improve speed and lower limb muscular strength
      and neuro-muscular co-ordination. Terminalia arjuna may prove useful to improve
      cardio-vascular endurance and lowering systolic blood pressure. Both drugs appear
      to be safe for young adults when given for mentioned dosage and duration.
FAU - Sandhu, Jaspal Singh
AU  - Sandhu JS
AD  - Department of Sports Medicine and Physiotherapy, Guru Nanak Dev University,
      Amritsar, Punjab - 143 005, India.
FAU - Shah, Biren
AU  - Shah B
FAU - Shenoy, Shweta
AU  - Shenoy S
FAU - Chauhan, Suresh
AU  - Chauhan S
FAU - Lavekar, G S
AU  - Lavekar GS
FAU - Padhi, M M
AU  - Padhi MM
LA  - eng
PT  - Journal Article
PL  - India
TA  - Int J Ayurveda Res
JT  - International journal of Ayurveda research
JID - 101527491
PMC - PMC2996571
OTO - NOTNLM
OT  - Absolute and relative power
OT  - Terminalia arjuna
OT  - Withania somnifera
OT  - balance
OT  - blood pressure
OT  - maximum oxygen consumption (VO2 max)
OT  - velocity
EDAT- 2010/12/21 06:00
MHDA- 2010/12/21 06:01
CRDT- 2010/12/21 06:00
PHST- 2010/04/19 00:00 [received]
PHST- 2010/09/09 00:00 [accepted]
PHST- 2010/12/21 06:00 [entrez]
PHST- 2010/12/21 06:00 [pubmed]
PHST- 2010/12/21 06:01 [medline]
AID - 10.4103/0974-7788.72485 [doi]
PST - ppublish
SO  - Int J Ayurveda Res. 2010 Jul;1(3):144-9. doi: 10.4103/0974-7788.72485.


PMID- 21170118
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 1388-0764 (Print)
IS  - 1388-0764 (Linking)
VI  - 12
IP  - 6
DP  - 2010 Aug
TI  - Multicriteria mapping of stakeholder preferences in regulating nanotechnology.
PG  - 1959-1970
AB  - In order to facilitate stakeholder discussions on how to regulate nanotechnology,
      the opensource program multicriteria mapping (MCM) was used to structure 26
      interviews with stakeholders in the USA. MCM offers a systematic part
      quantitative, part qualitative approach to clarify why some regulatory options
      (bans, moratoriums, voluntary measures, etc.) were deemed to be
      acceptable/unacceptable by various stakeholders and which criteria stakeholders
      used to evaluate the different regulatory options. Adopting an incremental
      approach and implementing a new regulatory framework was evaluated as the best
      options whereas a complete ban and no additional regulation of nanotechnology
      were found to be the least favorable. Criteria applied differed substantially
      among stakeholders and included social, ethical, regulatory, environmental, and
      health issues. Opinions on future regulation seem far less polarized than
      expected and it seems that stakeholders would welcome a combination of voluntary 
      measures, an incremental approach and forming of a new regulatory framework.
      ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article
      (doi:10.1007/s11051-010-0006-3) contains supplementary material, which is
      available to authorized users.
FAU - Hansen, Steffen Foss
AU  - Hansen SF
AD  - Department of Environmental Engineering, NanoDTU, Technical University of
      Denmark, Building 113, 2800 Kgs, Lyngby, Denmark.
LA  - eng
PT  - Journal Article
DEP - 20100630
PL  - Netherlands
TA  - J Nanopart Res
JT  - Journal of nanoparticle research : an interdisciplinary forum for nanoscale
      science and technology
JID - 101088075
PMC - PMC2988199
EDAT- 2010/12/21 06:00
MHDA- 2010/12/21 06:01
CRDT- 2010/12/21 06:00
PHST- 2009/09/21 00:00 [received]
PHST- 2010/06/18 00:00 [accepted]
PHST- 2010/12/21 06:00 [entrez]
PHST- 2010/12/21 06:00 [pubmed]
PHST- 2010/12/21 06:01 [medline]
AID - 10.1007/s11051-010-0006-3 [doi]
PST - ppublish
SO  - J Nanopart Res. 2010 Aug;12(6):1959-1970. doi: 10.1007/s11051-010-0006-3. Epub
      2010 Jun 30.


PMID- 21169673
OWN - NLM
STAT- MEDLINE
DCOM- 20110414
LR  - 20190201
IS  - 2384-8553 (Electronic)
IS  - 0021-2571 (Linking)
VI  - 46
IP  - 4
DP  - 2010
TI  - Informed consent in experimentation involving mentally impaired persons: ethical 
      issues.
PG  - 411-21
LID - 10.4415/ANN_10_04_09 [doi]
AB  - The problem of experimentation involving subjects whose mental condition prevents
      them from understanding information and providing proper informed consent has
      been addressed in various codes, declarations, conventions, treaties and
      regulations adopted by national, international and supranational institutions and
      authorities. This article summarizes the basic ethical criteria these documents
      provide and stresses the historical development from the nearly total exclusion
      of incapacitated subjects, established in the mid-twentieth century, to their
      contemporary inclusion in clinical trials on certain ethical conditions. The
      problem of proxy consent by legal representatives for participation in clinical
      trials is addressed particularly in reference to current Italian regulations.
      Exceptions to human experimentation requirements in emergency situations are also
      briefly discussed.
FAU - Petrini, Carlo
AU  - Petrini C
AD  - Unita di Bioetica, Istituto Superiore di Sanita, Rome, Italy.
      carlo.petrini@iss.it
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - Ann Ist Super Sanita
JT  - Annali dell'Istituto superiore di sanita
JID - 7502520
SB  - IM
MH  - Emergency Medical Services
MH  - History, 20th Century
MH  - Human Experimentation/*ethics/history/*standards
MH  - Humans
MH  - Informed Consent/*ethics/history/*standards
MH  - Mental Disorders/*psychology
EDAT- 2010/12/21 06:00
MHDA- 2011/04/16 06:00
CRDT- 2010/12/21 06:00
PHST- 2010/12/21 06:00 [entrez]
PHST- 2010/12/21 06:00 [pubmed]
PHST- 2011/04/16 06:00 [medline]
AID - 10.4415/ANN_10_04_09 [doi]
PST - ppublish
SO  - Ann Ist Super Sanita. 2010;46(4):411-21. doi: 10.4415/ANN_10_04_09.


PMID- 21169170
OWN - NLM
STAT- MEDLINE
DCOM- 20110418
LR  - 20211020
IS  - 1438-8871 (Electronic)
IS  - 1438-8871 (Linking)
VI  - 12
IP  - 5
DP  - 2010 Dec 19
TI  - Ethical dilemmas in online research and treatment of sexually abused adolescents.
PG  - e58
LID - 10.2196/jmir.1455 [doi]
AB  - BACKGROUND: In a recent uncontrolled trial of a new therapist-assisted Web-based 
      treatment of adolescent victims of sexual abuse, the treatment effects were found
      to be promising. However, the study suffered a large pretreatment withdrawal rate
      that appeared to emanate from reluctance among the participants to disclose their
      identity and obtain their parents' consent. OBJECTIVE: Our objectives were to
      confirm the effects of the online treatment in a controlled trial and to evaluate
      measures to reduce pretreatment withdrawal in vulnerable populations including
      young victims of sexual abuse. METHODS: The study was designed as a
      within-subject baseline-controlled trial. Effects of an 8-week attention-placebo 
      intervention were contrasted with the effects of an 8-week treatment episode.
      Several measures were taken to reduce pretreatment dropout. RESULTS: Pretreatment
      withdrawal was reduced but remained high (82/106, 77%). On the other hand,
      treatment dropout was low (4 out of 24 participants), and improvement during
      treatment showed significantly higher effects than during the attention placebo
      control period (net effect sizes between 0.5 and 1.6). CONCLUSIONS: In treatment 
      of vulnerable young populations, caregivers and researchers will have to come to 
      terms with high pretreatment withdrawal rates. Possible measures may reduce
      pretreatment withdrawal to some degree. Providing full anonymity is not a viable 
      option since it is incompatible with the professional responsibility of the
      caregiver and restricts research possibilities.
FAU - Lange, Alfred
AU  - Lange A
AD  - Department of Clinical Psychology, University of Amsterdam, Amsterdam,
      Netherlands. a.lange@uva.nl
FAU - Ruwaard, Jeroen
AU  - Ruwaard J
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20101219
PL  - Canada
TA  - J Med Internet Res
JT  - Journal of medical Internet research
JID - 100959882
SB  - IM
MH  - Adolescent
MH  - Adolescent Behavior/*psychology
MH  - Child
MH  - Child Abuse, Sexual/psychology/*therapy
MH  - *Confidentiality
MH  - Crime Victims/*psychology/rehabilitation
MH  - Ethics, Medical
MH  - Female
MH  - Humans
MH  - Male
MH  - Patient Dropouts/statistics & numerical data
MH  - Professional-Patient Relations/*ethics
MH  - Therapy, Computer-Assisted/*ethics/methods
MH  - Vulnerable Populations/psychology
PMC - PMC3057314
EDAT- 2010/12/21 06:00
MHDA- 2011/04/19 06:00
CRDT- 2010/12/21 06:00
PHST- 2010/01/07 00:00 [received]
PHST- 2010/04/27 00:00 [accepted]
PHST- 2010/12/21 06:00 [entrez]
PHST- 2010/12/21 06:00 [pubmed]
PHST- 2011/04/19 06:00 [medline]
AID - v12i5e58 [pii]
AID - 10.2196/jmir.1455 [doi]
PST - epublish
SO  - J Med Internet Res. 2010 Dec 19;12(5):e58. doi: 10.2196/jmir.1455.


PMID- 21169100
OWN - NLM
STAT- MEDLINE
DCOM- 20150126
LR  - 20101220
IS  - 1665-1731 (Electronic)
IS  - 1665-1731 (Linking)
VI  - 80
IP  - 4
DP  - 2010 Oct-Dec
TI  - [Some ethical dilemmas in the medical praxis].
PG  - 338-42
AB  - We reviewed from a bioethical perspective and attempting prevention of potential 
      conflicts derived communication failure during medical practice, palliative
      treatments and dignified death in the institutional practice as well as general
      practice; most of conflicts related to patient-doctor relationship could de
      prevented. We propose an attitude and aptitude plus in deep knowledge of patient,
      family, friends and legal representatives in terms fully honest communication to 
      prevent most of conflicts and avoid its consequences against doctors and other
      health workers. Prevention is better and it depends of knowledge of norms, laws, 
      general beliefs and common sense in this country and maybe others.
FAU - Reyes, Pedro A
AU  - Reyes PA
AD  - Secretario de la Comision de Bioetica del INCICh.
FAU - Delong-Tapia, Rocio del Carmen
AU  - Delong-Tapia Rdel C
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Algunos dilemas eticos en la practica medica.
PL  - Mexico
TA  - Arch Cardiol Mex
JT  - Archivos de cardiologia de Mexico
JID - 101126728
SB  - IM
MH  - *Bioethical Issues
MH  - *Ethics, Medical
MH  - Humans
EDAT- 2010/12/21 06:00
MHDA- 2015/01/27 06:00
CRDT- 2010/12/21 06:00
PHST- 2010/12/21 06:00 [entrez]
PHST- 2010/12/21 06:00 [pubmed]
PHST- 2015/01/27 06:00 [medline]
AID - 14059940804020 [pii]
PST - ppublish
SO  - Arch Cardiol Mex. 2010 Oct-Dec;80(4):338-42.


PMID- 21169063
OWN - NLM
STAT- MEDLINE
DCOM- 20110623
LR  - 20110131
IS  - 1472-6491 (Electronic)
IS  - 1472-6483 (Linking)
VI  - 22
IP  - 2
DP  - 2011 Feb
TI  - Nuclear transfer to prevent mitochondrial DNA disorders: revisiting the debate on
      reproductive cloning.
PG  - 200-7
LID - 10.1016/j.rbmo.2010.10.016 [doi]
AB  - Preclinical experiments are currently performed to examine the feasibility of
      several types of nuclear transfer to prevent mitochondrial DNA (mtDNA) disorders.
      Whereas the two most promising types of nuclear transfer to prevent mtDNA
      disorders, spindle transfer and pronuclear transfer, do not amount to
      reproductive cloning, one theoretical variant, blastomere transfer does. This
      seems the most challenging both technically and ethically. It is prohibited by
      many jurisdictions and also the scientific community seems to avoid it.
      Nevertheless, this paper examines the moral acceptability of blastomere transfer 
      as a method to prevent mtDNA disorders. The reason for doing so is that most
      objections against reproductive cloning refer to reproductive adult cloning,
      while blastomere transfer would amount to reproductive embryo cloning. After
      clarifying this conceptual difference, this paper examines whether the main
      non-safety objections brought forward against reproductive cloning also apply in 
      the context of blastomere transfer. The conclusion is that if this variant were
      to become safe and effective, dismissing it because it would involve reproductive
      cloning is unjustified. Nevertheless, as it may lead to more complex ethical
      appraisals than the other variants, researchers should initially focus on the
      development of the other types of nuclear transfer to prevent mtDNA disorders.
CI  - Copyright (c) 2010 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All
      rights reserved.
FAU - Bredenoord, A L
AU  - Bredenoord AL
AD  - Maastricht University and University Medical Center, Utrecht, The Netherlands.
      a.l.bredenoord@umcutrecht.nl
FAU - Dondorp, W
AU  - Dondorp W
FAU - Pennings, G
AU  - Pennings G
FAU - De Wert, G
AU  - De Wert G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101112
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
SB  - IM
MH  - Blastomeres/transplantation
MH  - Cloning, Organism/*ethics/methods
MH  - Humans
MH  - Mitochondrial Diseases/*prevention & control
MH  - Nuclear Transfer Techniques/*ethics
EDAT- 2010/12/21 06:00
MHDA- 2011/06/24 06:00
CRDT- 2010/12/21 06:00
PHST- 2010/05/10 00:00 [received]
PHST- 2010/09/03 00:00 [revised]
PHST- 2010/10/26 00:00 [accepted]
PHST- 2010/12/21 06:00 [entrez]
PHST- 2010/12/21 06:00 [pubmed]
PHST- 2011/06/24 06:00 [medline]
AID - S1472-6483(10)00713-3 [pii]
AID - 10.1016/j.rbmo.2010.10.016 [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2011 Feb;22(2):200-7. doi: 10.1016/j.rbmo.2010.10.016. Epub
      2010 Nov 12.


PMID- 21168923
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20181201
IS  - 1872-8464 (Electronic)
IS  - 0165-5876 (Linking)
VI  - 75
IP  - 3
DP  - 2011 Mar
TI  - Comparison of peritonsillar levobupivacaine and bupivacaine infiltration for
      post-tonsillectomy pain relief in children: placebo-controlled clinical study.
PG  - 322-6
LID - 10.1016/j.ijporl.2010.11.015 [doi]
AB  - OBJECTIVES: To compare the effects of preincisional peritonsillar infiltration of
      levobupivacaine and bupivacaine on post-tonsillectomy pain in children. METHODS: 
      Sixty children undergoing elective tonsillectomy or adenotonsillectomy were
      randomly allocated into three groups before tonsillectomy: peritonsillar
      infiltrations with 0.25% levobupivacaine with 1:200,000 epinephrine (group
      levobupivacaine, n=20), 0.25% bupivacaine with 1:200,000 epinephrine (group
      bupivacaine, n=20), and normal saline (group saline, n=20) were applied. Pain was
      evaluated by using a modified Children's Hospital of Eastern Ontario Pain Scale
      (mCHEOPS). Choice of additional analgesic was acetaminophen for all patients.
      RESULTS: mCHEOPS values at 0th (immediately) and 30th minute after arrival the
      PACU were lower in both the local anesthetics groups than the saline group
      (p<0.001, p<0.01 for the group levobupivacaine; p<0.001, p<0.05 for the group
      bupivacaine, respectively). In addition, mCHEOPS values at 1st hour in the ward
      was lower in the group bupivacaine when compared to the group saline (p<0.05).
      Analgesic requirements and the time to first analgesia required, were also
      significantly different between the local anesthetic and saline groups (p<0.05
      for both local anesthetics groups). Time to first mobilization was shorter in
      both local anesthetic groups when compared to the saline group (p<0.05 for both
      local anesthetic groups). CONCLUSION: Preincisional peritonsillar infiltration
      with levobupivacaine or bupivacaine before tonsillectomy, are effective than
      saline, in reducing early post-tonsillectomy pain, where as bupivacaine had
      slightly longer effect. Compared to saline, with both anesthetic infiltrations,
      lesser medication for analgesia is required. The clinical trial registration
      number (Research Ethics Committee of Medical Faculty, Uludag University):
      2008-4/36, 19 February 2008.
CI  - Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Kasapoglu, Fikret
AU  - Kasapoglu F
AD  - Department of Otorhinolaryngology, Uludag University, Nilufer, 16059 Bursa,
      Turkey. fkasapoglu@uludag.edu.tr
FAU - Kaya, Fatma Nur
AU  - Kaya FN
FAU - Tuzemen, Gokhan
AU  - Tuzemen G
FAU - Ozmen, Omer Afsin
AU  - Ozmen OA
FAU - Kaya, Atila
AU  - Kaya A
FAU - Onart, Selcuk
AU  - Onart S
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20101218
PL  - Ireland
TA  - Int J Pediatr Otorhinolaryngol
JT  - International journal of pediatric otorhinolaryngology
JID - 8003603
RN  - 0 (Analgesics, Non-Narcotic)
RN  - 0 (Anesthetics, Local)
RN  - 362O9ITL9D (Acetaminophen)
RN  - A5H73K9U3W (Levobupivacaine)
RN  - Y8335394RO (Bupivacaine)
SB  - IM
MH  - Acetaminophen/therapeutic use
MH  - Analgesics, Non-Narcotic/therapeutic use
MH  - Anesthetics, Local/*administration & dosage
MH  - Bupivacaine/*administration & dosage/analogs & derivatives
MH  - Child
MH  - Drug Utilization
MH  - Female
MH  - Humans
MH  - Injections
MH  - Levobupivacaine
MH  - Male
MH  - Pain Measurement
MH  - Pain, Postoperative/*prevention & control
MH  - Prospective Studies
MH  - Time Factors
MH  - *Tonsillectomy
EDAT- 2010/12/21 06:00
MHDA- 2011/07/27 06:00
CRDT- 2010/12/21 06:00
PHST- 2010/08/26 00:00 [received]
PHST- 2010/11/09 00:00 [revised]
PHST- 2010/11/13 00:00 [accepted]
PHST- 2010/12/21 06:00 [entrez]
PHST- 2010/12/21 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
AID - S0165-5876(10)00538-0 [pii]
AID - 10.1016/j.ijporl.2010.11.015 [doi]
PST - ppublish
SO  - Int J Pediatr Otorhinolaryngol. 2011 Mar;75(3):322-6. doi:
      10.1016/j.ijporl.2010.11.015. Epub 2010 Dec 18.


PMID- 21168720
OWN - NLM
STAT- MEDLINE
DCOM- 20110425
LR  - 20101220
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 42
IP  - 10
DP  - 2010 Dec
TI  - The practical, moral, and ethical considerations of the new Israeli law for the
      allocation of donor organs.
PG  - 4475-8
LID - 10.1016/j.transproceed.2010.09.146 [doi]
AB  - There is a worldwide shortage of organs for transplantation; the number of
      patients on the waiting list exceeds the supply of available organs. The demand
      for organ donation is particularly concerning in Israel. A new Israeli law has
      been instituted to give those who sign donor cards allocation priority if they
      are ever in need of an organ transplant themselves. A number of variations on
      this paradigm that considers the willingness of patients to donate their own
      organs have since been proposed; however, the new Israeli policy for organ
      donation is the first time such a law has been implemented nationally.
      Prioritization of organ allocation to donors comes with a significant moral and
      ethical debate, and since its implementation in January 2010 there has been much 
      controversy surrounding the new policy. This article provides a description of
      the new Israeli plan, specifically focusing on the practical, moral, and ethical 
      debates surrounding the new system.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Gruenbaum, B F
AU  - Gruenbaum BF
AD  - Jakobovits Center for Jewish Medical Ethics, Faculty of Health Sciences,
      Ben-Gurion University of the Negev, Beer-Sheva, Israel.
FAU - Jotkowitz, A
AU  - Jotkowitz A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - *Ethics
MH  - Health Care Rationing/*legislation & jurisprudence
MH  - Humans
MH  - Israel
MH  - *Morals
MH  - *Organ Transplantation
EDAT- 2010/12/21 06:00
MHDA- 2011/04/26 06:00
CRDT- 2010/12/21 06:00
PHST- 2010/08/25 00:00 [received]
PHST- 2010/09/28 00:00 [accepted]
PHST- 2010/12/21 06:00 [entrez]
PHST- 2010/12/21 06:00 [pubmed]
PHST- 2011/04/26 06:00 [medline]
AID - S0041-1345(10)01579-4 [pii]
AID - 10.1016/j.transproceed.2010.09.146 [doi]
PST - ppublish
SO  - Transplant Proc. 2010 Dec;42(10):4475-8. doi: 10.1016/j.transproceed.2010.09.146.


PMID- 21167237
OWN - NLM
STAT- MEDLINE
DCOM- 20110928
LR  - 20110606
IS  - 1872-8294 (Electronic)
IS  - 0169-409X (Linking)
VI  - 63
IP  - 4-5
DP  - 2011 Apr 30
TI  - From tissue engineering to regenerative medicine in urology--the potential and
      the pitfalls.
PG  - 375-8
LID - 10.1016/j.addr.2010.12.003 [doi]
AB  - Tissue engineering is a promising technique for the development of biological
      substitutes that can restore, maintain, or improve tissue function. The creation 
      of human tissue-engineered products, generated of autologous somatic cells or
      adult stem cells with or without seeding of biocompatible matrices is a vision to
      resolve the lack of tissues and organs for transplantation and to offer new
      options for reconstructive surgery. Tissue engineering in urology aims at the
      reconstruction of the urinary tract by creating anatomically and functionally
      equal tissue. It is a rapidly evolving field in basic research and the transfer
      into the clinic has yet to be realized. Necessary steps from bench to bed are the
      proof of principle in animal models and the proof of concept in clinical trials
      following good manufacturing practice and ethical and legal requirements for
      human tissue-engineered products. Up to now, obstacles still occur in the
      neovascularization of implants and ingrowth of nerves in vivo. Moreover the
      harvesting of mesenchymal stem cells out of bone marrow as well as the explant of
      urothelial cells yet demands rather invasive surgery to achieve a successful
      outcome. Thus, other cell sources and harvesting techniques like placenta and
      adipose tissue for mesenchymal stem cells and bladder irrigation for urothelial
      cells require closer investigation.
CI  - Copyright (c) 2010. Published by Elsevier B.V.
FAU - Feil, Gerhard
AU  - Feil G
AD  - Dept. of Urology, University of Tuebingen, Hoppe-Seyler-Strasse 3, Tuebingen,
      Germany.
FAU - Daum, Lisa
AU  - Daum L
FAU - Amend, Bastian
AU  - Amend B
FAU - Maurer, Sabine
AU  - Maurer S
FAU - Renninger, Markus
AU  - Renninger M
FAU - Vaegler, Martin
AU  - Vaegler M
FAU - Seibold, Jorg
AU  - Seibold J
FAU - Stenzl, Arnulf
AU  - Stenzl A
FAU - Sievert, Karl-Dietrich
AU  - Sievert KD
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20101215
PL  - Netherlands
TA  - Adv Drug Deliv Rev
JT  - Advanced drug delivery reviews
JID - 8710523
SB  - IM
MH  - Animals
MH  - Humans
MH  - Models, Biological
MH  - Neovascularization, Physiologic
MH  - Reconstructive Surgical Procedures/methods
MH  - Regenerative Medicine/*methods
MH  - Tissue Engineering/*methods
MH  - Tissue Scaffolds
MH  - Urinary Tract/pathology/*surgery
MH  - Urologic Diseases/therapy
EDAT- 2010/12/21 06:00
MHDA- 2011/09/29 06:00
CRDT- 2010/12/21 06:00
PHST- 2010/10/14 00:00 [received]
PHST- 2010/12/01 00:00 [revised]
PHST- 2010/12/07 00:00 [accepted]
PHST- 2010/12/21 06:00 [entrez]
PHST- 2010/12/21 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - S0169-409X(10)00290-5 [pii]
AID - 10.1016/j.addr.2010.12.003 [doi]
PST - ppublish
SO  - Adv Drug Deliv Rev. 2011 Apr 30;63(4-5):375-8. doi: 10.1016/j.addr.2010.12.003.
      Epub 2010 Dec 15.


PMID- 21166762
OWN - NLM
STAT- MEDLINE
DCOM- 20111031
LR  - 20220311
IS  - 1464-410X (Electronic)
IS  - 1464-4096 (Linking)
VI  - 108
IP  - 5
DP  - 2011 Sep
TI  - First 500 cases of robotic-assisted laparoscopic radical prostatectomy from a
      single UK centre: learning curves of two surgeons.
PG  - 739-47
LID - 10.1111/j.1464-410X.2010.09941.x [doi]
AB  - OBJECTIVE: * To study the outcomes and learning curve of robotic-assisted
      laparoscopic radical prostatectomy (RALP) in a single centre by two surgeons.
      PATIENTS AND METHODS: * In total, 500 consecutive patients underwent RALP between
      2005 and 2009 carried out by two surgeons. Using an ethically-approved database, 
      prospective data collection of demographic, surgical, oncological and functional 
      outcomes (patient reported) was performed, with up to 4 years of follow-up. * The
      learning curves of both surgeons were analyzed and, in addition, the first 100
      and last 100 patients were compared to determine the effect of surgeon
      experience. RESULTS: * The mean age of the patients was 61.5 years and mean
      preoperative prostate-specific antigen was 7.0 microg/L. Clinical stages were T1 
      in 63.2%, T2 in 33.8% and T3 in 3.0% of patients. Median (range) operating time
      was 170 (63-420) min and median (range) blood loss was 200 (20-3000) mL, with
      significant improvements for both surgeons with increasing experience (P < 0.001 
      and P= 0.029, respectively). * Pathological stages were pT2 in 53.4%, pT3a in
      41.6%, pT3b in 4.0% and pT4 in 0.6% of patients. Overall, the positive margin
      rate (PMR) was 24.0% and stage-specific rates were 16.1%, 30.4%, 55.0% and 100.0%
      for pT2, pT3a, pT3b and pT4 disease, respectively. In the last 50 cases performed
      by each surgeon, the PMRs for pT2 and pT3a disease were 8.0% and 19.1% (surgeon
      1) and 12.9% and 23.5% (surgeon 2). * At 12 months of follow-up, 91.3% of
      patients were continent and, by 48 months of follow-up, 75% of men with
      preoperative potency who underwent bilateral nerve-sparing RALP were potent.
      CONCLUSION: * This is the first report of two surgeons' learning curves in a
      single centre and shows that key learning curve outcomes continued to improve
      during the series, suggesting that the learning curve for RALP may be longer than
      has been previously suggested.
CI  - (c) 2010 THE AUTHORS. BJU INTERNATIONAL (c) 2010 BJU INTERNATIONAL.
FAU - Sharma, Naomi Laura
AU  - Sharma NL
AD  - Addenbrooke's Hospital - Urology, Cambridge, UK. naomi.sharma@cancer.org.uk
FAU - Papadopoulos, Alexandros
AU  - Papadopoulos A
FAU - Lee, Dominic
AU  - Lee D
FAU - McLoughlin, John
AU  - McLoughlin J
FAU - Vowler, Sarah L
AU  - Vowler SL
FAU - Baumert, Herve
AU  - Baumert H
FAU - Warren, Anne Y
AU  - Warren AY
FAU - Patil, Vishal
AU  - Patil V
FAU - Shah, Nimish
AU  - Shah N
FAU - Neal, David E
AU  - Neal DE
LA  - eng
GR  - G0900871/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
DEP - 20101216
PL  - England
TA  - BJU Int
JT  - BJU international
JID - 100886721
RN  - 0 (Biomarkers, Tumor)
RN  - EC 3.4.21.77 (Prostate-Specific Antigen)
SB  - IM
CIN - BJU Int. 2011 Sep;108(5):747. PMID: 21854527
CIN - BJU Int. 2011 Sep;108(5):747-8. PMID: 21854528
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/blood
MH  - Humans
MH  - Learning Curve
MH  - Male
MH  - Mentors
MH  - Middle Aged
MH  - Postoperative Complications/etiology/prevention & control
MH  - Prostate-Specific Antigen/blood
MH  - Prostatectomy/*education/methods
MH  - Prostatic Neoplasms/immunology/*surgery
MH  - Robotics/*education
MH  - Time Factors
MH  - Treatment Outcome
MH  - United Kingdom
EDAT- 2010/12/21 06:00
MHDA- 2011/11/01 06:00
CRDT- 2010/12/21 06:00
PHST- 2010/12/21 06:00 [entrez]
PHST- 2010/12/21 06:00 [pubmed]
PHST- 2011/11/01 06:00 [medline]
AID - 10.1111/j.1464-410X.2010.09941.x [doi]
PST - ppublish
SO  - BJU Int. 2011 Sep;108(5):739-47. doi: 10.1111/j.1464-410X.2010.09941.x. Epub 2010
      Dec 16.


PMID- 21164086
OWN - NLM
STAT- MEDLINE
DCOM- 20120117
LR  - 20211020
IS  - 1541-0048 (Electronic)
IS  - 0090-0036 (Linking)
VI  - 101 Suppl 1
DP  - 2011 Dec
TI  - Understanding community-based processes for research ethics review: a national
      study.
PG  - S359-64
LID - 10.2105/AJPH.2010.194340 [doi]
AB  - OBJECTIVES: Institutional review boards (IRBs), designed to protect individual
      study participants, do not routinely assess community consent, risks, and
      benefits. Community groups are establishing ethics review processes to determine 
      whether and how research is conducted in their communities. To strengthen the
      ethics review of community-engaged research, we sought to identify and describe
      these processes. METHODS: In 2008 we conducted an online survey of US-based
      community groups and community-institutional partnerships involved in
      human-participants research. We identified 109 respondents who met participation 
      criteria and had ethics review processes in place. RESULTS: The respondents'
      processes mainly functioned through community-institutional partnerships,
      community-based organizations, community health centers, and tribal
      organizations. These processes had been created primarily to ensure that the
      involved communities were engaged in and directly benefited from research and
      were protected from research harms. The primary process benefits included giving 
      communities a voice in determining which studies were conducted and ensuring that
      studies were relevant and feasible, and that they built community capacity. The
      primary process challenges were the time and resources needed to support the
      process. CONCLUSIONS: Community-based processes for ethics review consider
      community-level ethical issues that institution-based IRBs often do not.
FAU - Shore, Nancy
AU  - Shore N
AD  - Westbrook College of Health Professions, School of Social Work, University of New
      England, Portland, ME 04103, USA. nshore@une.edu
FAU - Brazauskas, Ruta
AU  - Brazauskas R
FAU - Drew, Elaine
AU  - Drew E
FAU - Wong, Kristine A
AU  - Wong KA
FAU - Moy, Lisa
AU  - Moy L
FAU - Baden, Andrea Corage
AU  - Baden AC
FAU - Cyr, Kirsten
AU  - Cyr K
FAU - Ulevicus, Jocelyn
AU  - Ulevicus J
FAU - Seifer, Sarena D
AU  - Seifer SD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101216
PL  - United States
TA  - Am J Public Health
JT  - American journal of public health
JID - 1254074
SB  - IM
MH  - *Community-Based Participatory Research
MH  - Community-Institutional Relations
MH  - Data Collection
MH  - *Ethical Review/economics
MH  - Ethics Committees, Research/standards
MH  - Humans
MH  - United States
PMC - PMC3222468
EDAT- 2010/12/18 06:00
MHDA- 2012/01/18 06:00
CRDT- 2010/12/18 06:00
PHST- 2010/12/18 06:00 [entrez]
PHST- 2010/12/18 06:00 [pubmed]
PHST- 2012/01/18 06:00 [medline]
AID - AJPH.2010.194340 [pii]
AID - 10.2105/AJPH.2010.194340 [doi]
PST - ppublish
SO  - Am J Public Health. 2011 Dec;101 Suppl 1:S359-64. doi: 10.2105/AJPH.2010.194340. 
      Epub 2010 Dec 16.


PMID- 21163919
OWN - NLM
STAT- MEDLINE
DCOM- 20110317
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 258
IP  - 2
DP  - 2011 Feb
TI  - Plaque hemorrhage is a marker of thromboembolic activity in patients with
      symptomatic carotid disease.
PG  - 538-45
LID - 10.1148/radiol.10100198 [doi]
AB  - PURPOSE: To assess whether carotid plaque hemorrhage depicted with magnetic
      resonance (MR) imaging was associated with thromboembolic activity as assessed
      with transcranial Doppler imaging. MATERIALS AND METHODS: The local research
      ethics committee approved the study, and all patients gave informed written
      consent. Between April 2005 and December 2006, patients with high-grade
      symptomatic carotid stenosis were prospectively recruited. All underwent MR
      imaging of the carotid arteries for plaque hemorrhage and diffusion-weighted
      imaging of the brain. Transcranial Doppler imaging of the symptomatic carotid
      artery was performed over 1 hour to assess the presence of microembolic signal.
      To determine the relationship between the presence of plaque hemorrhage and
      diffusion-weighted imaging-positive signal and presence of microembolic signal, a
      logistic regression analysis was performed. RESULTS: Fifty-one patients (23 women
      and 28 men; mean age +/- standard deviation, 72 years +/- 11) underwent complete 
      MR imaging; 46 (86%) of these patients underwent complete transcranial Doppler
      imaging. In 32 (63%) patients, there was plaque hemorrhage in the index carotid
      artery. The presence of plaque hemorrhage increased the risk for ipsilateral
      abnormalities at diffusion-weighted imaging (odds ratio, 6.2 [95% confidence
      interval: 1.7, 21.8]; P < .05). Multiple diffusion-weighted imaging-depicted
      abnormalities of multiple ages were present exclusively in patients with plaque
      hemorrhage shown at MR imaging (12 of 32 [38%] patients with plaque hemorrhage
      versus none of 19 patients without plaque hemorrhage; P < .05). The presence of
      plaque hemorrhage also increased the presence of microembolic signal (odds ratio,
      6.0 [95% confidence interval: 1.8, 19.9]; P = .003). CONCLUSION: In patients with
      carotid plaque hemorrhage demonstrated at MR imaging, there was increased
      spontaneous microembolic activity at transcranial Doppler imaging and cerebral
      ischemic lesion patterns suggestive of recurrent embolic events; these findings
      suggest that plaque hemorrhage shown at MR imaging might be a marker of
      thromboembolic activity and further validate the usefulness of carotid imaging in
      identifying patients with active carotid arterial disease.
CI  - (c) RSNA, 2010.
FAU - Altaf, Nishath
AU  - Altaf N
AD  - Department of Academic Radiology, University of Nottingham, Queen's Medical
      Centre, Derby Road, Nottingham NG7 2UH, England. nishaltaf@gmail.com
FAU - Goode, Stephen D
AU  - Goode SD
FAU - Beech, Andrew
AU  - Beech A
FAU - Gladman, John R F
AU  - Gladman JR
FAU - Morgan, Paul S
AU  - Morgan PS
FAU - MacSweeney, Shane T
AU  - MacSweeney ST
FAU - Auer, Dorothee P
AU  - Auer DP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101216
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Aged
MH  - Brain Ischemia/*diagnostic imaging
MH  - Carotid Stenosis/*diagnostic imaging
MH  - Diffusion Magnetic Resonance Imaging
MH  - Female
MH  - Hemorrhage/*diagnostic imaging
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Recurrence
MH  - Thromboembolism/*diagnostic imaging
MH  - *Ultrasonography, Doppler, Transcranial
EDAT- 2010/12/18 06:00
MHDA- 2011/03/18 06:00
CRDT- 2010/12/18 06:00
PHST- 2010/12/18 06:00 [entrez]
PHST- 2010/12/18 06:00 [pubmed]
PHST- 2011/03/18 06:00 [medline]
AID - radiol.10100198 [pii]
AID - 10.1148/radiol.10100198 [doi]
PST - ppublish
SO  - Radiology. 2011 Feb;258(2):538-45. doi: 10.1148/radiol.10100198. Epub 2010 Dec
      16.


PMID- 21163855
OWN - NLM
STAT- MEDLINE
DCOM- 20110426
LR  - 20110513
IS  - 1460-2350 (Electronic)
IS  - 0268-1161 (Linking)
VI  - 26
IP  - 2
DP  - 2011 Feb
TI  - Characterization of invasive trophoblasts generated from human embryonic stem
      cells.
PG  - 398-406
LID - 10.1093/humrep/deq350 [doi]
AB  - BACKGROUND: Abnormal human embryo implantation leads to poor foetal development
      and miscarriage, or pre-eclampsia. Ethical and practical considerations
      concerning implantation limit its investigation, and it is often difficult to
      extrapolate findings in laboratory animals when implantation processes show
      diverse species differences. Therefore, it is important to develop new in vitro
      models to study the earliest events of human implantation. The aim of this study 
      was to derive trophoblast cell lines from human embryonic stem cells (hESCs) by a
      robust protocol and co-culture of these cells with an established endometrial
      cell culture system to validate a model of trophoblast invasion at implantation. 
      METHODS: Derivation of trophoblast cell lines from hESC lines was established by 
      spontaneous and induced differentiation of embryoid bodies and by initial
      measurement of hCGbeta secretion by enzyme-linked immunosorbent assay and their
      phenotype investigated using gene- and protein-expression markers. Vesicles
      formed from an aggregating trophoblast were co-cultured with decidualized human
      endometrial stromal cells in hypoxic (2% oxygen) and normoxic (20% oxygen)
      environments. RESULTS: Derived villous cytotrophoblast cell (CTB) lines further
      differentiated to invasive, extra-villous CTBs. Eventually, cells lost their
      proliferative capacity, with some lines acquiring karyotypic changes, such as a
      gain in the X chromosome. Cell-invasion assays confirmed that the extra-villous
      CTBs were invasive and erosion of the endometrial stromal layer occurred,
      particularly under hypoxic conditions in vitro. CONCLUSIONS: Trophoblast cell
      lines derived from hESCs differentiate and adapt in vitro and can be used as a
      model to study the mechanisms of early trophoblast invasion.
FAU - Udayashankar, R
AU  - Udayashankar R
AD  - Centre for Stem Cell Biology, University of Sheffield, Sheffield S10 2TN, UK.
      ramya.udayashankar@ge.com
FAU - Baker, D
AU  - Baker D
FAU - Tuckerman, E
AU  - Tuckerman E
FAU - Laird, S
AU  - Laird S
FAU - Li, T C
AU  - Li TC
FAU - Moore, H D
AU  - Moore HD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101216
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
RN  - EC 3.4.24.24 (Matrix Metalloproteinase 2)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Cell Differentiation
MH  - Cell Line
MH  - Chromosome Aberrations
MH  - Coculture Techniques
MH  - Embryo Implantation/*physiology
MH  - Embryonic Stem Cells/*cytology
MH  - Female
MH  - Gene Expression
MH  - Humans
MH  - Matrix Metalloproteinase 2/biosynthesis
MH  - Matrix Metalloproteinase 9/biosynthesis
MH  - Models, Biological
MH  - Pregnancy
MH  - Trophoblasts/cytology/*physiology
EDAT- 2010/12/18 06:00
MHDA- 2011/04/27 06:00
CRDT- 2010/12/18 06:00
PHST- 2010/12/18 06:00 [entrez]
PHST- 2010/12/18 06:00 [pubmed]
PHST- 2011/04/27 06:00 [medline]
AID - deq350 [pii]
AID - 10.1093/humrep/deq350 [doi]
PST - ppublish
SO  - Hum Reprod. 2011 Feb;26(2):398-406. doi: 10.1093/humrep/deq350. Epub 2010 Dec 16.


PMID- 21163201
OWN - NLM
STAT- MEDLINE
DCOM- 20120731
LR  - 20110228
IS  - 1578-1968 (Electronic)
IS  - 0213-4853 (Linking)
VI  - 26
IP  - 2
DP  - 2011 Mar
TI  - Ethical problems arising from the use of placebo in clinical trials with drugs
      for migraine. Their analysis by the moral deliberation method.
PG  - 92-9
LID - 10.1016/j.nrl.2010.09.028 [doi]
AB  - INTRODUCTION: Migraine is characterised as episodes of headache plus a variety of
      accompanying symptoms. Its pharmacological control remains unsatisfactory for
      some patients. The use of placebo in drug clinical trials on migraine commonly
      leads to numerous ethical uncertainties. METHODS: The purpose of this paper is to
      illustrate how the deliberation method helps in analysing the issues and finding 
      solutions to selected ethical problems. Ethical decisions that try to solve
      conflicts arising from placebo use in clinical trials may be adopted using the
      moral deliberation method. Thus, the conflict is systematically assessed by
      identifying the following: Relevant facts; Values in conflict; Duties, or in
      other words, possible courses of action. Moral duty is following the optimal
      course of action. To identify this, it is recommended to state extreme courses of
      action, then intermediate courses of action, and then to proceed to the optimal
      course(s) of action. RESULTS AND CONCLUSIONS: In this paper, the application of
      this method is shown in several conflicting situations arising in two
      placebo-controlled clinical trials with drugs under development for the
      prophylaxis and acute treatment of migraine.
CI  - Copyright (c) 2010 Sociedad Espanola de Neurologia. Published by Elsevier Espana.
      All rights reserved.
FAU - Frias, J
AU  - Frias J
AD  - Servicio de Farmacologia Clinica, Hospital Universitario La Paz, Madrid, Spain.
FAU - Pascual, J
AU  - Pascual J
FAU - Lahuerta, J
AU  - Lahuerta J
FAU - Gracia, D
AU  - Gracia D
FAU - Dal-Re, R
AU  - Dal-Re R
LA  - eng
LA  - spa
PT  - Case Reports
PT  - Journal Article
DEP - 20101214
PL  - Spain
TA  - Neurologia
JT  - Neurologia (Barcelona, Spain)
JID - 9005460
RN  - 0 (Placebos)
SB  - IM
MH  - Adult
MH  - *Bioethical Issues
MH  - Clinical Trials as Topic/*ethics
MH  - Female
MH  - Humans
MH  - Migraine Disorders/*drug therapy/*prevention & control
MH  - *Morals
MH  - Placebos/*therapeutic use
EDAT- 2010/12/18 06:00
MHDA- 2012/08/01 06:00
CRDT- 2010/12/18 06:00
PHST- 2010/07/12 00:00 [received]
PHST- 2010/09/24 00:00 [revised]
PHST- 2010/09/29 00:00 [accepted]
PHST- 2010/12/18 06:00 [entrez]
PHST- 2010/12/18 06:00 [pubmed]
PHST- 2012/08/01 06:00 [medline]
AID - S0213-4853(10)00273-2 [pii]
AID - 10.1016/j.nrl.2010.09.028 [doi]
PST - ppublish
SO  - Neurologia. 2011 Mar;26(2):92-9. doi: 10.1016/j.nrl.2010.09.028. Epub 2010 Dec
      14.


PMID- 21163083
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150521
LR  - 20101217
IS  - 0255-7053 (Print)
IS  - 0255-7053 (Linking)
VI  - 40
IP  - 5
DP  - 2010 Sep
TI  - [Liu Yue-heng and Shengcaoyaoxingfangpu (Guidebook of Chinese medicinal herbal
      properties)].
PG  - 292-302
AB  - Liu Yue-heng, a famous doctor in Hunan province during Qing dynasty is the author
      of Shengcaoyaoxingfangpu (Guidebook of Chinese medicinal herbs) which
      systematically summed up the properties, flavors and channel tropism of the local
      herbal medicines and supplemented a lack knowledge of those. The book collected
      broadly folk and proved prescriptions and, combined with the author's clinical
      experiences. He collected and classified them as chapters, reflected geographical
      environment and folk custom culture with the distinctive regional characteristics
      of Huxiang. Its achievement is mainly embodied in the following aspects: it
      attached importance to herbs, highlighted Huxiang characteristics, the skilful
      use of folk and proved prescriptions and comprehensively differentiated etiology 
      and pathogenesis, and proposed for doctors' professional ethics.
FAU - Zhang, Lu-Li
AU  - Zhang LL
AD  - Guangxi TCM University, Nanning, 530001, China.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Shi Za Zhi
JT  - Zhonghua yi shi za zhi (Beijing, China : 1980)
JID - 8303081
EDAT- 2010/12/18 06:00
MHDA- 2010/12/18 06:01
CRDT- 2010/12/18 06:00
PHST- 2010/12/18 06:00 [entrez]
PHST- 2010/12/18 06:00 [pubmed]
PHST- 2010/12/18 06:01 [medline]
PST - ppublish
SO  - Zhonghua Yi Shi Za Zhi. 2010 Sep;40(5):292-302.


PMID- 21162340
OWN - NLM
STAT- MEDLINE
DCOM- 20110404
LR  - 20181023
IS  - 1751-486X (Electronic)
IS  - 1751-4851 (Linking)
VI  - 14
IP  - 6
DP  - 2010 Dec-2011 Jan
TI  - Ethical nursing practice: why it should concern us all.
PG  - 443-6
LID - 10.1111/j.1751-486X.2010.01590.x [doi]
FAU - McCrink, Andrea
AU  - McCrink A
AD  - Adelphi University, Garden City, NY, USA. amccrink@adelphi.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Nurs Womens Health
JT  - Nursing for women's health
JID - 101304602
MH  - Education, Nursing/ethics
MH  - *Ethics, Nursing
MH  - Humans
MH  - Nurse-Patient Relations/*ethics
MH  - *Students, Nursing
EDAT- 2010/12/18 06:00
MHDA- 2011/04/05 06:00
CRDT- 2010/12/18 06:00
PHST- 2010/12/18 06:00 [entrez]
PHST- 2010/12/18 06:00 [pubmed]
PHST- 2011/04/05 06:00 [medline]
AID - S1751-4851(15)30536-5 [pii]
AID - 10.1111/j.1751-486X.2010.01590.x [doi]
PST - ppublish
SO  - Nurs Womens Health. 2010 Dec-2011 Jan;14(6):443-6. doi:
      10.1111/j.1751-486X.2010.01590.x.


PMID- 21162168
OWN - NLM
STAT- MEDLINE
DCOM- 20110330
LR  - 20211020
IS  - 1332-8166 (Electronic)
IS  - 0353-9504 (Linking)
VI  - 51
IP  - 6
DP  - 2010 Dec
TI  - Reflections on running training workshops for research ethics committee members
      in Spain between 2001 and 2008.
PG  - 552-9
AB  - AIM: To present the experience of running workshops for members of research
      ethics committees (REC) in Spain from 2001-2008 by a non-profit institution.
      METHODS: We analyzed data from 7 sessions of the course, involving 165 health
      professionals. Data were taken from an opinion survey conducted at the end of
      each seminar and a deferred questionnaire sent after the workshops. RESULTS:
      Opinions of 122 participants who completed the first questionnaire (84% of the
      146 attendees) on these training courses were very positive (median, >/= 4.5 out 
      of 5). The second questionnaire was administered a few months after each session,
      and a total of 43 participants responded (36% of 118). The participants improved 
      their knowledge, attitude, and skills (median, 4.0 out of 5) in most of the areas
      evaluated. Furthermore, they believed that training for REC members should be
      mandatory (median, 5.0 out of 5) and carried out regularly (median, 4.0 out of
      5). The lack of communication between RECs and limitations in monitoring clinical
      trials (median, 4.5 out of 5) were the main problems according to respondents.
      Training was rated as a strong necessity (median, 4.0 out of 5). CONCLUSION: The 
      courses were well received, they contributed to the overall learning of the
      participants, and served to highlight some of the major problems faced by REC
      members. These results emphasize the importance of training.
FAU - Banos, Josep-E
AU  - Banos JE
AD  - Department of Experimental and Health Sciences, Universitat Pompeu Fabra,
      Barcelona, Spain.
FAU - Lucena, M Isabel
AU  - Lucena MI
FAU - Seres, Elisabet
AU  - Seres E
FAU - Bosch, Felix
AU  - Bosch F
LA  - eng
PT  - Journal Article
PL  - Croatia
TA  - Croat Med J
JT  - Croatian medical journal
JID - 9424324
SB  - IM
MH  - Biomedical Research/ethics/*organization & administration/standards
MH  - *Curriculum
MH  - Data Collection
MH  - Educational Status
MH  - Ethics Committees, Research/*organization & administration/standards/statistics &
      numerical data
MH  - Ethics, Research/*education
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Spain
MH  - Statistics, Nonparametric
MH  - Surveys and Questionnaires
PMC - PMC3012400
EDAT- 2010/12/17 06:00
MHDA- 2011/03/31 06:00
CRDT- 2010/12/17 06:00
PHST- 2010/12/17 06:00 [entrez]
PHST- 2010/12/17 06:00 [pubmed]
PHST- 2011/03/31 06:00 [medline]
AID - 10.3325/cmj.2010.51.552 [doi]
PST - ppublish
SO  - Croat Med J. 2010 Dec;51(6):552-9. doi: 10.3325/cmj.2010.51.552.


PMID- 21161840
OWN - NLM
STAT- MEDLINE
DCOM- 20110207
LR  - 20101216
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 12
DP  - 2010 Dec
TI  - Moral aspects of bariatric surgery for obese children and adolescents: the urgent
      need for empirical-ethical research.
PG  - 30-2
LID - 10.1080/15265161.2010.528514 [doi]
FAU - van Geelen, S M
AU  - van Geelen SM
AD  - University Medical Center, Utrecht, The Netherlands. s.m.vangeelen@umcutrecht.nl
FAU - Bolt, L L E
AU  - Bolt LL
FAU - van Summeren, M J H
AU  - van Summeren MJ
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2010 Dec;10(12):3-11. PMID: 21161829
MH  - Adolescent
MH  - Bariatric Surgery/adverse effects/economics/*ethics
MH  - Child
MH  - Chronic Disease
MH  - Empirical Research
MH  - Humans
MH  - Life Style
MH  - Obesity/etiology/psychology/*surgery
MH  - Self Concept
MH  - Social Isolation
MH  - Social Responsibility
EDAT- 2010/12/17 06:00
MHDA- 2011/02/08 06:00
CRDT- 2010/12/17 06:00
PHST- 2010/12/17 06:00 [entrez]
PHST- 2010/12/17 06:00 [pubmed]
PHST- 2011/02/08 06:00 [medline]
AID - 931176914 [pii]
AID - 10.1080/15265161.2010.528514 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Dec;10(12):30-2. doi: 10.1080/15265161.2010.528514.


PMID- 21161836
OWN - NLM
STAT- MEDLINE
DCOM- 20110207
LR  - 20101216
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 12
DP  - 2010 Dec
TI  - Bariatric surgery, ethical obligation, and the life cycle of medical innovation.
PG  - 22-4
LID - 10.1080/15265161.2010.528526 [doi]
FAU - De Ville, Kenneth
AU  - De Ville K
AD  - Brody School of Medicine, Bioethics and Interdisciplinary Studies, Greenville, NC
      27834, USA. devillek@ecu.edu
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2010 Dec;10(12):3-11. PMID: 21161829
MH  - Bariatric Surgery/ethics/*standards/*trends
MH  - Humans
MH  - Knowledge
MH  - Moral Obligations
MH  - Obesity/*surgery
MH  - Randomized Controlled Trials as Topic
MH  - Registries
MH  - Therapies, Investigational/standards/trends
EDAT- 2010/12/17 06:00
MHDA- 2011/02/08 06:00
CRDT- 2010/12/17 06:00
PHST- 2010/12/17 06:00 [entrez]
PHST- 2010/12/17 06:00 [pubmed]
PHST- 2011/02/08 06:00 [medline]
AID - 931187865 [pii]
AID - 10.1080/15265161.2010.528526 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Dec;10(12):22-4. doi: 10.1080/15265161.2010.528526.


PMID- 21161832
OWN - NLM
STAT- MEDLINE
DCOM- 20110207
LR  - 20101216
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 12
DP  - 2010 Dec
TI  - Parsing neurobiological dysfunctions in obesity: nosologic and ethical
      consequences.
PG  - 14-6
LID - 10.1080/15265161.2010.528521 [doi]
FAU - Fisher, Carl E
AU  - Fisher CE
AD  - Columbia University, the New York State Psychiatric Institute, New York, NY, USA.
      carl.e.fisher@gmail.com
FAU - Devlin, Michael J
AU  - Devlin MJ
FAU - Appelbaum, Paul S
AU  - Appelbaum PS
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2010 Dec;10(12):3-11. PMID: 21161829
MH  - *Eating
MH  - *Emotions
MH  - Humans
MH  - Neurobiology
MH  - Obesity/classification/*etiology/genetics/psychology
MH  - *Personal Autonomy
MH  - Risk Factors
MH  - Stress, Psychological/*complications
MH  - *Volition
EDAT- 2010/12/17 06:00
MHDA- 2011/02/08 06:00
CRDT- 2010/12/17 06:00
PHST- 2010/12/17 06:00 [entrez]
PHST- 2010/12/17 06:00 [pubmed]
PHST- 2011/02/08 06:00 [medline]
AID - 931187942 [pii]
AID - 10.1080/15265161.2010.528521 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Dec;10(12):14-6. doi: 10.1080/15265161.2010.528521.


PMID- 21161829
OWN - NLM
STAT- MEDLINE
DCOM- 20110207
LR  - 20141120
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 12
DP  - 2010 Dec
TI  - Stuck in the middle: the many moral challenges with bariatric surgery.
PG  - 3-11
LID - 10.1080/15265161.2010.528509 [doi]
AB  - Bariatric surgery is effective on short- and medium-term weight loss, reduction
      of comorbidities, and overall mortality. A large and increasing portion of the
      population is eligible for bariatric surgery, which increases instant health care
      costs. A review of the literature identifies a series of ethical challenges:
      unjust distribution of bariatric surgery, autonomy and informed consent,
      classification of obesity and selecting assessment endpoints, prejudice among
      health professionals, intervention in people's life-world, and medicalization of 
      appearance. Bariatric surgery is particularly interesting because it uses
      surgical methods to modify healthy organs, is not curative, but offers symptoms
      relief for a condition that it is considered to result from lack of self-control 
      and is subject to significant prejudice. Taking the reviewed ethical issues into 
      account is important when meeting persons eligible for bariatric surgery, as well
      as in the assessment of and decision making on surgery for obesity.
FAU - Hofmann, Bjorn
AU  - Hofmann B
AD  - University College of Gjovik, University of Oslo, Oslo, Norway.
      bjoern.hofmann@hig.no
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CIN - Am J Bioeth. 2010 Dec;10(12):1-2. PMID: 21161827
CIN - Am J Bioeth. 2010 Dec;10(12):W1-2. PMID: 21161828
CIN - Am J Bioeth. 2010 Dec;10(12):12-3. PMID: 21161831
CIN - Am J Bioeth. 2010 Dec;10(12):14-6. PMID: 21161832
CIN - Am J Bioeth. 2010 Dec;10(12):16-8. PMID: 21161833
CIN - Am J Bioeth. 2010 Dec;10(12):18-20. PMID: 21161834
CIN - Am J Bioeth. 2010 Dec;10(12):20-2. PMID: 21161835
CIN - Am J Bioeth. 2010 Dec;10(12):22-4. PMID: 21161836
CIN - Am J Bioeth. 2010 Dec;10(12):24-6. PMID: 21161837
CIN - Am J Bioeth. 2010 Dec;10(12):27-8. PMID: 21161838
CIN - Am J Bioeth. 2010 Dec;10(12):28-30. PMID: 21161839
CIN - Am J Bioeth. 2010 Dec;10(12):30-2. PMID: 21161840
MH  - Bariatric Surgery/economics/*ethics
MH  - Choice Behavior
MH  - Cost-Benefit Analysis
MH  - Cultural Characteristics
MH  - Ethical Analysis
MH  - Global Health
MH  - Health Policy
MH  - Health Status Disparities
MH  - *Healthcare Disparities
MH  - Humans
MH  - Informed Consent
MH  - Obesity, Morbid/economics/*surgery/therapy
MH  - *Personal Autonomy
MH  - *Physician-Patient Relations
MH  - Prejudice
MH  - Risk Reduction Behavior
EDAT- 2010/12/17 06:00
MHDA- 2011/02/08 06:00
CRDT- 2010/12/17 06:00
PHST- 2010/12/17 06:00 [entrez]
PHST- 2010/12/17 06:00 [pubmed]
PHST- 2011/02/08 06:00 [medline]
AID - 931193598 [pii]
AID - 10.1080/15265161.2010.528509 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Dec;10(12):3-11. doi: 10.1080/15265161.2010.528509.


PMID- 21161828
OWN - NLM
STAT- MEDLINE
DCOM- 20110207
LR  - 20161125
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 12
DP  - 2010 Dec
TI  - The encompassing ethics of bariatric surgery.
PG  - W1-2
LID - 10.1080/15265161.2010.530912 [doi]
FAU - Hofmann, Bjorn
AU  - Hofmann B
AD  - Section for Medical Ethics, University of Oslo, Oslo, Norway.
      bjoern.hofmann@hig.no
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2010 Dec;10(12):3-11. PMID: 21161829
MH  - Bariatric Surgery/adverse effects/*ethics
MH  - Empirical Research
MH  - Ethical Theory
MH  - Feeding Behavior
MH  - Health Policy
MH  - Humans
MH  - Life Style
MH  - Obesity, Morbid/etiology/*surgery
MH  - Public Health
MH  - Randomized Controlled Trials as Topic
MH  - Social Problems
EDAT- 2010/12/17 06:00
MHDA- 2011/02/08 06:00
CRDT- 2010/12/17 06:00
PHST- 2010/12/17 06:00 [entrez]
PHST- 2010/12/17 06:00 [pubmed]
PHST- 2011/02/08 06:00 [medline]
AID - 931189346 [pii]
AID - 10.1080/15265161.2010.530912 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Dec;10(12):W1-2. doi: 10.1080/15265161.2010.530912.


PMID- 21161724
OWN - NLM
STAT- MEDLINE
DCOM- 20110830
LR  - 20220408
IS  - 1534-4681 (Electronic)
IS  - 1068-9265 (Linking)
VI  - 18
IP  - 6
DP  - 2011 Jun
TI  - Multifocality in "basal-like" breast carcinomas and its influence on lymph node
      status.
PG  - 1671-7
LID - 10.1245/s10434-010-1480-7 [doi]
AB  - BACKGROUND: Basal-like breast carcinomas often are regarded for circumscribed
      solitary lesions having unfavorable prognosis. On the other hand, a considerable 
      proportion of breast carcinomas is multifocal and has increased metastatic
      potential. In this study, we analyzed the subgross distribution of the lesions in
      a series of basal-like carcinomas, compared it with that in nonbasal-like tumors 
      and studied the frequency of vascular invasion and lymph node metastasis in
      relation to focality of the lesions. METHODS: A total of 511 consecutive cases
      documented in large-format histologic sections were studied. Tumors expressing at
      least one of the basal (myoepithelial) markers (CK5/6, CK14, EGFR) in at least
      one of the invasive tumor foci were categorized as basal-like tumors.
      Triple-negative (ER/PR/HER-2-negative) basal-like carcinomas also were analyzed. 
      The distribution of lesions and the frequency of vascular invasion and lymph node
      metastasis were analyzed. The study was approved by the Regional Ethical
      Committee Uppsala-Orebro. RESULTS: In 44% of cases, the invasive component was
      multifocal or diffuse. Combining the in situ and invasive tumor components
      resulted in 61% of cases with multifocal/diffuse distribution. The only
      statistically significant difference observed was that basal-like tumors lacked
      in situ components more often (21% vs. 9%; P = 0.0075). No significant
      differences could be demonstrated regarding vascular invasion and lymph node
      status. Lymph node metastasis appeared significantly more frequently in
      multifocal cases in both tumor categories. CONCLUSIONS: Basal-like breast
      carcinomas are as frequently multifocal as their non-basal-like counterparts;
      multifocality is associated with increased risk for vascular invasion and lymph
      node metastasis in both tumor categories.
FAU - Tot, Tibor
AU  - Tot T
AD  - Department of Pathology and Clinical Cytology, Central Hospital Falun, Falun,
      Sweden. tibor.tot@ltdalarna.se
FAU - Pekar, Gyula
AU  - Pekar G
LA  - eng
PT  - Journal Article
DEP - 20101216
PL  - United States
TA  - Ann Surg Oncol
JT  - Annals of surgical oncology
JID - 9420840
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/metabolism
MH  - Breast Neoplasms/metabolism/*pathology
MH  - Carcinoma, Basal Cell/metabolism/*pathology
MH  - Female
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Lymph Nodes/*pathology
MH  - Lymphatic Metastasis
MH  - Middle Aged
MH  - Neoplasm Invasiveness
MH  - Prognosis
MH  - Retrospective Studies
EDAT- 2010/12/17 06:00
MHDA- 2011/08/31 06:00
CRDT- 2010/12/17 06:00
PHST- 2010/06/05 00:00 [received]
PHST- 2010/12/17 06:00 [entrez]
PHST- 2010/12/17 06:00 [pubmed]
PHST- 2011/08/31 06:00 [medline]
AID - 10.1245/s10434-010-1480-7 [doi]
PST - ppublish
SO  - Ann Surg Oncol. 2011 Jun;18(6):1671-7. doi: 10.1245/s10434-010-1480-7. Epub 2010 
      Dec 16.


PMID- 21161412
OWN - NLM
STAT- MEDLINE
DCOM- 20120614
LR  - 20120227
IS  - 1573-6814 (Electronic)
IS  - 1389-9333 (Linking)
VI  - 13
IP  - 1
DP  - 2012 Mar
TI  - The importance of ethic in the field of human tissue banking.
PG  - 103-17
LID - 10.1007/s10561-010-9232-2 [doi]
AB  - A tissue bank is accountable before the community in fulfilling the expectations 
      of tissue donors, their families and recipients. The expected output from the
      altruistic donation is that safe and high quality human tissue grafts will be
      provided for the medical treatment of patients. Thus, undertakings of tissue
      banks have to be not only authorised and audited by national competent health
      care authorities, but also comply with a strong ethical code, a code of practices
      and ethical principles. Ethical practice in the field of tissue banking requires 
      the setting of principles, the identification of possible deviations and the
      establishment of mechanisms that will detect and hinder abuses that may occur
      during the procurement, processing and distribution of human tissues for
      transplantation. The opinions and suggestions manifested by the authors in this
      paper may not be necessarily a reflection of those within the institutions or
      community they are linked to.
FAU - Morales Pedraza, Jorge
AU  - Morales Pedraza J
AD  - jmorales47@hotmail.com
FAU - Herson, Marisa Roma
AU  - Herson MR
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20101215
PL  - Netherlands
TA  - Cell Tissue Bank
JT  - Cell and tissue banking
JID - 100965121
SB  - IM
MH  - Codes of Ethics
MH  - Ethics Committees
MH  - Health
MH  - Humans
MH  - Informed Consent
MH  - Tissue Banks/*ethics
MH  - Tissue Donors/ethics
EDAT- 2010/12/17 06:00
MHDA- 2012/06/15 06:00
CRDT- 2010/12/17 06:00
PHST- 2009/11/21 00:00 [received]
PHST- 2010/11/04 00:00 [accepted]
PHST- 2010/12/17 06:00 [entrez]
PHST- 2010/12/17 06:00 [pubmed]
PHST- 2012/06/15 06:00 [medline]
AID - 10.1007/s10561-010-9232-2 [doi]
PST - ppublish
SO  - Cell Tissue Bank. 2012 Mar;13(1):103-17. doi: 10.1007/s10561-010-9232-2. Epub
      2010 Dec 15.


PMID- 21160850
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1948-9366 (Electronic)
VI  - 2
IP  - 3
DP  - 2010 Mar 27
TI  - Liver resections for liver transplantations.
PG  - 51-6
LID - 10.4240/wjgs.v2.i3.51 [doi]
AB  - Split-Liver and living-related donor liver transplantation are the newest and
      both technically and ethically most challenging developments in liver
      transplantation and have contributed to a reduction in donor shortage. We report 
      the technical aspects of surgical procedures performed to achieve a partial graft
      from a cadaveric and a live donor.
FAU - Gruttadauria, Salvatore
AU  - Gruttadauria S
AD  - Salvatore Gruttadauria, Fabrizio di Francesco, Duilio Pagano, Sergio Li Petri,
      Davide Cintorino, Marco Spada, Bruno Gridelli, Mediterranean Institute for
      Transplantation and High Specialization Therapies, University of Pittsburgh
      Medical Center in Italy, Palermo 90127, Italy.
FAU - Francesco, Fabrizio di
AU  - Francesco Fd
FAU - Pagano, Duilio
AU  - Pagano D
FAU - Petri, Sergio Li
AU  - Petri SL
FAU - Cintorino, Davide
AU  - Cintorino D
FAU - Spada, Marco
AU  - Spada M
FAU - Gridelli, Bruno
AU  - Gridelli B
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Gastrointest Surg
JT  - World journal of gastrointestinal surgery
JID - 101532473
PMC - PMC2999215
OTO - NOTNLM
OT  - Liver resections
OT  - Liver surgery
OT  - Liver transplantation
OT  - Living-related liver transplantation
OT  - Split liver transplantation
EDAT- 2010/12/17 06:00
MHDA- 2010/12/17 06:01
CRDT- 2010/12/17 06:00
PHST- 2009/11/06 00:00 [received]
PHST- 2010/02/22 00:00 [revised]
PHST- 2009/03/01 00:00 [accepted]
PHST- 2010/12/17 06:00 [entrez]
PHST- 2010/12/17 06:00 [pubmed]
PHST- 2010/12/17 06:01 [medline]
AID - 10.4240/wjgs.v2.i3.51 [doi]
PST - ppublish
SO  - World J Gastrointest Surg. 2010 Mar 27;2(3):51-6. doi: 10.4240/wjgs.v2.i3.51.


PMID- 21160810
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1948-5204 (Electronic)
VI  - 2
IP  - 1
DP  - 2010 Jan 15
TI  - Significance of biological resource collection and tumor tissue bank creation.
PG  - 5-8
LID - 10.4251/wjgo.v2.i1.5 [doi]
AB  - Progress in the molecular oncology of gastrointestinal carcinomas depends on high
      quality cancer tissues for research. Recent acceleration on new technological
      platforms as well as the "omics" revolution increases the demands on tissues and 
      peripheral blood for research at the DNA, mRNA and protein levels. Tissue bank
      creation emerges as a priority. Tumor tissue banks are facilities that are
      organized to collect, store and distribute samples of tumor and normal tissue for
      further use in basic and translational cancer research. The samples are generally
      obtained immediately after excision, prior to fixation, to ensure optimal
      preservation of proteins and nucleic acids. It is possible for surgeons or
      pathologists to collect fresh tissue prospectively during their routine
      dissection procedures. Most tissue banks are "project-driven" tumor banks, which 
      are specialized collections of tumor samples on which their research is based.
      Systematic collection of all available tumor tissue is much rarer. High quality
      tissue banks need the collaboration of clinicians and basic scientists, but also 
      the informed consent of patients and ethical approval. Through the standard
      operation procedure, snap frozen fresh tissue collection, storage and quality
      control for cryopreserved tissues are the pivotal factors on tissue bank
      construction and maintaining. The purpose of the tissue bank creation is
      enhancing the quality and speed on both the basic and translational research on
      gastrointestinal cancer. The quality assurance and quality control are handled
      based on reviewing HE staining slides or touch imprint cytology by pathologists.
FAU - Yu, Ying-Yan
AU  - Yu YY
AD  - Ying-Yan Yu, Zheng-Gang Zhu, Department of Surgery, Shanghai Institute of
      Digestive Surgery, School of Medicine, Shanghai Jiao Tong University, 200025
      Shanghai, China.
FAU - Zhu, Zheng-Gang
AU  - Zhu ZG
LA  - eng
PT  - Journal Article
PL  - China
TA  - World J Gastrointest Oncol
JT  - World journal of gastrointestinal oncology
JID - 101532470
PMC - PMC2999151
OTO - NOTNLM
OT  - Bioresource
OT  - Cryopreservation
OT  - Quality control
OT  - Tissue bank
EDAT- 2010/12/17 06:00
MHDA- 2010/12/17 06:01
CRDT- 2010/12/17 06:00
PHST- 2009/02/01 00:00 [received]
PHST- 2009/07/04 00:00 [revised]
PHST- 2009/07/11 00:00 [accepted]
PHST- 2010/12/17 06:00 [entrez]
PHST- 2010/12/17 06:00 [pubmed]
PHST- 2010/12/17 06:01 [medline]
AID - 10.4251/wjgo.v2.i1.5 [doi]
PST - ppublish
SO  - World J Gastrointest Oncol. 2010 Jan 15;2(1):5-8. doi: 10.4251/wjgo.v2.i1.5.


PMID- 21160535
OWN - NLM
STAT- MEDLINE
DCOM- 20110509
LR  - 20110128
IS  - 1745-655X (Electronic)
IS  - 0197-5897 (Linking)
VI  - 32
IP  - 1
DP  - 2011 Feb
TI  - Smoking in prisons: the need for effective and acceptable interventions.
PG  - 32-45
LID - 10.1057/jphp.2010.47 [doi]
AB  - Tobacco-smoking prevalence has been decreasing in many high-income countries, but
      not in prison. We provide a summary of recent data on smoking in prison (United
      States, Australia, and Europe), and discuss examples of implemented policies for 
      responding to environmental tobacco smoke (ETS), their health, humanitarian, and 
      ethical aspects. We gathered data through a systematic literature review, and
      added the authors' ongoing experience in the implementation of smoking policies
      outside and inside prisons in Australia and Europe. Detainees' smoking prevalence
      varies between 64 per cent and 91.8 per cent, and can be more than three times as
      high as in the general population. Few data are available on the prevalence of
      smoking in women detainees and staff. Policies vary greatly. Bans may either be
      'total' or 'partial' (smoking allowed in cells or designated places). A
      comprehensive policy strategy to reduce ETS needs a harm minimization philosophy,
      and should include environmental restrictions, information, and support to
      detainees and staff for smoking cessation, and health staff training in smoking
      cessation.
FAU - Ritter, Catherine
AU  - Ritter C
AD  - University Center of Legal Medicine of Geneva and Lausanne, Rue Michel-Servet 1, 
      CH-1211 Geneva, Switzerland. Bernice.Elger@unige.ch
FAU - Stover, Heino
AU  - Stover H
FAU - Levy, Michael
AU  - Levy M
FAU - Etter, Jean-Francois
AU  - Etter JF
FAU - Elger, Bernice
AU  - Elger B
LA  - eng
PT  - Journal Article
DEP - 20101216
PL  - England
TA  - J Public Health Policy
JT  - Journal of public health policy
JID - 8006508
SB  - IM
MH  - Australia/epidemiology
MH  - Europe/epidemiology
MH  - Female
MH  - *Health Promotion
MH  - Humans
MH  - Male
MH  - Organizational Policy
MH  - *Prisons
MH  - Smoking/*epidemiology
MH  - United States/epidemiology
EDAT- 2010/12/17 06:00
MHDA- 2011/05/10 06:00
CRDT- 2010/12/17 06:00
PHST- 2010/12/17 06:00 [entrez]
PHST- 2010/12/17 06:00 [pubmed]
PHST- 2011/05/10 06:00 [medline]
AID - jphp201047 [pii]
AID - 10.1057/jphp.2010.47 [doi]
PST - ppublish
SO  - J Public Health Policy. 2011 Feb;32(1):32-45. doi: 10.1057/jphp.2010.47. Epub
      2010 Dec 16.


PMID- 21159157
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211020
IS  - 1749-799X (Electronic)
IS  - 1749-799X (Linking)
VI  - 5
DP  - 2010 Dec 15
TI  - Anabolic steroids after total knee arthroplasty. A double blinded prospective
      pilot study.
PG  - 93
LID - 10.1186/1749-799X-5-93 [doi]
AB  - BACKGROUND: Total knee arthroplasty is reported to improve the patient's quality 
      of life and mobility. However loss of mobility and pain prior to surgery often
      results in disuse atrophy of muscle. As a consequence the baseline functional
      state prior to surgery may result in poorer outcome "post surgery" and extended
      rehabilitation may be required. The use of anabolic steroids for performance
      enhancement and to influence muscle mass is well established. The positive
      effects of such treatment on bone and muscle could therefore be beneficial in the
      rehabilitation of elderly patients. The purpose of this study was to investigate 
      the effects of small doses of Nandrolone decanoate on recovery and muscle
      strength after total knee replacement and to establish the safety of this drug in
      multimorbid patients. METHODS: This study was designed as a prospective double
      blind randomized investigation. Five patients (treatment group) with a mean age
      of 66.2 (58-72), average BMI of 30.76 (24.3-35.3) received 50 mg nandrolone
      decanoate intramuscular bi-weekly for 6 months. The control group (five patients;
      mean age 65.2, range 59-72; average BMI 31.7, range 21.2-35.2) was injected with 
      saline solution. "Pre-operatively" and "post-operatively" (6 weeks, 3,6,9 and 12 
      months) all patients were assessed using the knee society score (KSS), isokinetic
      strength testing and functional tests (a sit-to-stand and timed walking tests).
      In addition, a bone density scan was used preoperatively and 6 month
      postoperatively to assess bone mineral density. RESULTS: Whilst the steroid group
      generally performed better than the placebo group for all of the functional
      tests, ANOVA failed to reveal any significant differences. The steroid group
      demonstrated higher levels of quadriceps muscle strength across the postoperative
      period which reached significance at 3 (p = 0.02), 6 (p = 0.01), and 12 months (p
      = 0.02). There was a significant difference for the KSS at 6 weeks (p = 0.02), 6 
      (p = 0.02) and 12 month (p = 0.01). The steroid group demonstrated a reduction in
      the amount of bone mineral density at both the femur and lumbar spine from "pre-"
      to "post-surgery", however, these results did not reach significance (p < 0.05)
      using one-way ANOVA. CONCLUSIONS: This project strongly suggests that the use of 
      anabolic steroids result in an improved outcome as assessed by the KSS and
      significantly increases extensor strength. No side effects were seen in either
      the study or control group. TRIAL REGISTRATION NUMBER: Regional Health District: 
      Register No. 03.05Human Research Ethics Committee University: Clearance Number:
      04/03-19.
FAU - Hohmann, Erik
AU  - Hohmann E
AD  - Musculoskeletal Research Unit, Central Queensland University, Australia,
      Department of Orthopaedic Surgery, Clinical Medical School, University of
      Queensland, Australia. ehohmann@optusnet.com.au.
FAU - Tetsworth, Kevin
AU  - Tetsworth K
FAU - Hohmann, Stefanie
AU  - Hohmann S
FAU - Bryant, Adam L
AU  - Bryant AL
LA  - eng
PT  - Journal Article
DEP - 20101215
PL  - England
TA  - J Orthop Surg Res
JT  - Journal of orthopaedic surgery and research
JID - 101265112
PMC - PMC3009960
EDAT- 2010/12/17 06:00
MHDA- 2010/12/17 06:01
CRDT- 2010/12/17 06:00
PHST- 2010/08/04 00:00 [received]
PHST- 2010/12/15 00:00 [accepted]
PHST- 2010/12/17 06:00 [entrez]
PHST- 2010/12/17 06:00 [pubmed]
PHST- 2010/12/17 06:01 [medline]
AID - 1749-799X-5-93 [pii]
AID - 10.1186/1749-799X-5-93 [doi]
PST - epublish
SO  - J Orthop Surg Res. 2010 Dec 15;5:93. doi: 10.1186/1749-799X-5-93.


PMID- 21159023
OWN - NLM
STAT- MEDLINE
DCOM- 20110504
LR  - 20181201
IS  - 1460-9592 (Electronic)
IS  - 1155-5645 (Linking)
VI  - 21
IP  - 2
DP  - 2011 Feb
TI  - Changes of dorsalis pedis artery flow pattern after caudal block in children:
      observational study using a duplex sonography.
PG  - 116-20
LID - 10.1111/j.1460-9592.2010.03483.x [doi]
AB  - OBJECTIVE: To evaluate the changes of the flow velocity, the volume flow, and the
      diameter of dorsalis pedis artery using a duplex ultrasonography after caudal
      block with sevoflurane anesthesia in children. AIM: To know the acute change in
      peripheral arterial flow patterns of sympathetically blocked lower limbs in
      anesthetized children. BACKGROUND: Caudal analgesia in combination with general
      anesthesia may affect the circulatory hemodynamics due to sympatholytic
      vasodilating effects. METHODS: After approval by the Ethics Committee, we
      evaluated the changes of peripheral hemodynamics using a duplex ultrasonography
      before and after a caudal block in sevoflurane-anesthetized children. RESULTS: A 
      caudal block using 0.15% ropivacaine 1.5 ml.kg(-1) significantly altered the
      arterial flow patterns; increased peak velocity (24%) and volume flow (76%), and 
      the diameter of the dorsalis pedis artery (20%) in children. However, blood
      pressures and heart rates were not affected significantly by caudal block.
      CONCLUSIONS: Duplex sonographic measurements indicate that a caudal block changes
      the flow patterns of the dorsalis pedis artery significantly in the anesthetized 
      children.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Hong, Jeong-Yeon
AU  - Hong JY
AD  - Department of Anesthesiology and Pain Medicine, Yonsei University College of
      Medicine, Seoul, Korea.
FAU - Ahn, Seohui
AU  - Ahn S
FAU - Kil, Hae K
AU  - Kil HK
LA  - eng
PT  - Journal Article
DEP - 20101215
PL  - France
TA  - Paediatr Anaesth
JT  - Paediatric anaesthesia
JID - 9206575
RN  - 0 (Amides)
RN  - 0 (Anesthetics, Inhalation)
RN  - 0 (Anesthetics, Local)
RN  - 0 (Methyl Ethers)
RN  - 38LVP0K73A (Sevoflurane)
RN  - 7IO5LYA57N (Ropivacaine)
SB  - IM
MH  - Amides
MH  - Anesthesia, Caudal/*methods
MH  - Anesthesia, Inhalation
MH  - Anesthetics, Inhalation
MH  - Anesthetics, Local
MH  - Arteries/*diagnostic imaging/*drug effects
MH  - Blood Volume/physiology
MH  - Child, Preschool
MH  - Female
MH  - Hemodynamics/physiology
MH  - Humans
MH  - Infant
MH  - Male
MH  - Methyl Ethers
MH  - Monitoring, Intraoperative
MH  - Reproducibility of Results
MH  - Ropivacaine
MH  - Sevoflurane
MH  - Ultrasonography, Doppler, Duplex
MH  - Urologic Surgical Procedures
EDAT- 2010/12/17 06:00
MHDA- 2011/05/05 06:00
CRDT- 2010/12/17 06:00
PHST- 2010/12/17 06:00 [entrez]
PHST- 2010/12/17 06:00 [pubmed]
PHST- 2011/05/05 06:00 [medline]
AID - 10.1111/j.1460-9592.2010.03483.x [doi]
PST - ppublish
SO  - Paediatr Anaesth. 2011 Feb;21(2):116-20. doi: 10.1111/j.1460-9592.2010.03483.x.
      Epub 2010 Dec 15.


PMID- 21158889
OWN - NLM
STAT- MEDLINE
DCOM- 20111220
LR  - 20220409
IS  - 1471-6712 (Electronic)
IS  - 0283-9318 (Linking)
VI  - 25
IP  - 3
DP  - 2011 Sep
TI  - The meaning of reconciliation: women's stories about their experience of
      reconciliation with suffering from grief.
PG  - 525-32
LID - 10.1111/j.1471-6712.2010.00859.x [doi]
AB  - INTRODUCTION: Grief can be seen as a form of suffering. In this study grief was
      not only defined as loss, but as the process of inner suffering caused of some
      kinds of loss. We must recognise the importance of increased understanding for
      patient reconciliation with grief to expand earlier formulated knowledge about
      health and suffering. The aim of this study was to illuminate the meaning of
      reconciliation among women suffering from grief. METHODS: A qualitative
      explorative design with a hermeneutic narrative approach was used to analyse and 
      interpret the interviews. Caring theory about health, suffering and hermeneutical
      philosophy about understanding provided the point of departure for the analysis. 
      The study was approved by an ethical research committee. RESULTS: Findings reveal
      different plots that give light to the meaning of reconciliation in the different
      phases of analysis. In the women's narratives the meaning of reconciliation is a 
      process to a new way of seeing, but also to opening and transition from the
      experience of grief and suffering to the experience of health and wholeness.
      CONCLUSIONS: Reconciliation has a progressive form and the meaning of
      reconciliation cannot be seen as synonymous or homogenous but an understanding of
      reconciliation as a heterogenic synthesis of health and suffering. Understanding 
      the reconciliation process will enable nurses to plan and provide professional
      care, based on caring science.
CI  - (c) 2010 The Authors. Scandinavian Journal of Caring Sciences (c) 2010 Nordic
      College of Caring Science.
FAU - Gustafsson, Lena-Karin
AU  - Gustafsson LK
AD  - Department of Social and Caring Science, Abo University, Abo, Finland.
      lena-karin.gustafsson@mdh.se
FAU - Wiklund-Gustin, Lena
AU  - Wiklund-Gustin L
FAU - Lindstrom, Unni A
AU  - Lindstrom UA
LA  - eng
PT  - Journal Article
DEP - 20101216
PL  - Sweden
TA  - Scand J Caring Sci
JT  - Scandinavian journal of caring sciences
JID - 8804206
MH  - Female
MH  - *Grief
MH  - Humans
EDAT- 2010/12/17 06:00
MHDA- 2011/12/21 06:00
CRDT- 2010/12/17 06:00
PHST- 2010/12/17 06:00 [entrez]
PHST- 2010/12/17 06:00 [pubmed]
PHST- 2011/12/21 06:00 [medline]
AID - 10.1111/j.1471-6712.2010.00859.x [doi]
PST - ppublish
SO  - Scand J Caring Sci. 2011 Sep;25(3):525-32. doi: 10.1111/j.1471-6712.2010.00859.x.
      Epub 2010 Dec 16.


PMID- 21158376
OWN - NLM
STAT- MEDLINE
DCOM- 20110310
LR  - 20110915
IS  - 1938-2375 (Electronic)
IS  - 1542-8877 (Linking)
VI  - 41 Online
DP  - 2010 Jul 29
TI  - The usefulness of the "double-needle" technique for combined cataract extraction 
      and corneal transplantation.
PG  - 1-3
LID - 10.3928/15428877-20100726-09 [doi]
AB  - The authors report using double-needle cataract extraction in the course of
      triple surgery and describe the usefulness of a double-needle technique. Before
      penetrating preparation of the recipient cornea, two straight double-arm 10-0
      Prolene needles (Ethicon, Edinburgh, Scotland) were inserted in parallel on the
      recipient corneal bed transcorneally immediately anterior to the iris. The use of
      two needles stabilized the iris plane and offset positive vitreous pressure
      during triple surgery, continuous curvilinear capsulorrhexis,
      phacoemulsification, irrigation, and aspiration, allowing the safe implantation
      of an intraocular lens in the bag in an open-sky state. There were no procedural 
      difficulties and no complications. This simple technique using double needles in 
      triple surgery can be used effectively and may prevent forward movement of the
      lens-iris diaphragm, anterior capsular tearing, and rapid expulsion of the lens
      caused by positive vitreous pressure in the open-sky state.
CI  - Copyright 2010, SLACK Incorporated.
FAU - Choi, Suk Kyue
AU  - Choi SK
AD  - Department of Ophthalmology, Ilsan Paik Hospital, Inje University Medical
      College, Dae Wha-dong, Ilsanseo-ku, Koyang, Kyunggyi-do, Korea.
FAU - Kim, Jin Hyoung
AU  - Kim JH
FAU - Lee, Doh
AU  - Lee D
FAU - Yum, Jung Hoon
AU  - Yum JH
FAU - Moon, Nam Joo
AU  - Moon NJ
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20100729
PL  - United States
TA  - Ophthalmic Surg Lasers Imaging
JT  - Ophthalmic surgery, lasers & imaging : the official journal of the International 
      Society for Imaging in the Eye
JID - 101155780
SB  - IM
MH  - Adult
MH  - Cataract Extraction/instrumentation/*methods
MH  - *Corneal Transplantation
MH  - Corneal Ulcer/*surgery
MH  - Graft Rejection/surgery
MH  - Humans
MH  - Male
MH  - Needles
MH  - Phacoemulsification
MH  - Reoperation
MH  - Suture Techniques
EDAT- 2010/12/17 06:00
MHDA- 2011/03/11 06:00
CRDT- 2010/12/17 06:00
PHST- 2008/09/09 00:00 [received]
PHST- 2010/04/23 00:00 [accepted]
PHST- 2010/12/17 06:00 [entrez]
PHST- 2010/12/17 06:00 [pubmed]
PHST- 2011/03/11 06:00 [medline]
AID - 10.3928/15428877-20100726-09 [doi]
PST - epublish
SO  - Ophthalmic Surg Lasers Imaging. 2010 Jul 29;41 Online:1-3. doi:
      10.3928/15428877-20100726-09.


PMID- 21158261
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20161202
IS  - 2376-4317 (Print)
IS  - 2376-4317 (Linking)
VI  - 17
IP  - 4
DP  - 2010 Oct-Dec
TI  - Ethical issues in predictive pediatric genetic testing.
PG  - 6-7
FAU - Holaday, Bonnie
AU  - Holaday B
AD  - School of Nursing, Clemson University, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - S C Nurse (1994)
JT  - South Carolina nurse (Columbia, S.C. : 1994)
JID - 9423819
MH  - Child
MH  - Child Advocacy/*ethics
MH  - Genetic Testing/*ethics/methods
MH  - Humans
MH  - Infant, Newborn
MH  - Neonatal Screening/ethics/methods/nursing
MH  - Nurse's Role
MH  - Pediatric Nursing/*ethics
MH  - Pediatrics/ethics
MH  - Practice Guidelines as Topic
EDAT- 2010/12/17 06:00
MHDA- 2011/01/07 06:00
CRDT- 2010/12/17 06:00
PHST- 2010/12/17 06:00 [entrez]
PHST- 2010/12/17 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
PST - ppublish
SO  - S C Nurse (1994). 2010 Oct-Dec;17(4):6-7.


PMID- 21157702
OWN - NLM
STAT- MEDLINE
DCOM- 20110503
LR  - 20151119
IS  - 1469-5804 (Electronic)
IS  - 1357-6283 (Linking)
VI  - 23
IP  - 3
DP  - 2010 Nov
TI  - Interns' perceptions on medical ethics education and ethical issues at the Dokuz 
      Eylul University School of Medicine in Turkey.
PG  - 330
AB  - AIM: In Turkey and its neighboring countries, few studies have investigated
      medical students' reactions to ethics education and ethical issues they
      encounter. The aim of this study was to investigate interns' perceptions of
      medical ethics education and ethical issues. BACKGROUND: In students' first three
      years at the Dokuz Eylul University School of Medicine, various teaching methods 
      are used in ethics education, including problem-based learning, interactive
      lectures and movies. During the clinical years, the curriculum helps students
      consider the ethical dimension of their clinical work, and during the internship 
      period a discussion on ethical issues is held. MATERIAL AND METHODS: Data were
      collected through a questionnaire distributed to interns in the 2005-2006
      academic year. Its questions asked about interns' perceived adequacy of their
      ethics education, any interpersonal ethical problems they had witnessed, their
      approaches to ethical problems, obstacles they believe prevented them from
      resolving ethical problems and whether they felt themselves ready to deal with
      ethical problems. 67.2 % of interns were reached and all of them responded.
      RESULTS: In the assessment of the adequacy of ethics education, the most
      favorable score was given to educators. Students' most often mentioned ethical
      problems encountered were between physicians and students and between physicians 
      and patients. Interns believed that difficult personalities on the team and team 
      hierarchy were important obstacles to resolving ethical problems. There were
      significant differences between the approaches students currently used in dealing
      with ethical problems and how they anticipated they would approach these problems
      in their future professional lives. CONCLUSION: We obtained information about
      students' perceptions about ethics education and ethical problems which helped us
      to plan other educational activities. This study may assist other medical schools
      in preparing an ethics curriculum or help evaluate an existing curriculum.
FAU - Ozan, S
AU  - Ozan S
AD  - Dokuz Eylul University School of Medicine, Medical Education Department,
      Inciralti, Izmir, Turkey. semaozan@gmail.com
FAU - Timbil, S
AU  - Timbil S
FAU - Semin, S
AU  - Semin S
FAU - Musal, B
AU  - Musal B
LA  - eng
PT  - Journal Article
DEP - 20101020
PL  - India
TA  - Educ Health (Abingdon)
JT  - Education for health (Abingdon, England)
JID - 9607101
SB  - IM
MH  - Adult
MH  - Cross-Sectional Studies
MH  - Ethics, Medical/*education
MH  - Female
MH  - Humans
MH  - *Internship and Residency
MH  - Male
MH  - *Schools, Medical
MH  - Students, Medical/*psychology
MH  - Surveys and Questionnaires
MH  - Turkey
MH  - Young Adult
EDAT- 2010/12/16 06:00
MHDA- 2011/05/04 06:00
CRDT- 2010/12/16 06:00
PHST- 2010/12/16 06:00 [entrez]
PHST- 2010/12/16 06:00 [pubmed]
PHST- 2011/05/04 06:00 [medline]
AID - 330 [pii]
PST - ppublish
SO  - Educ Health (Abingdon). 2010 Nov;23(3):330. Epub 2010 Oct 20.


PMID- 21157524
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1179-5484 (Electronic)
IS  - 1179-5484 (Linking)
VI  - 4
DP  - 2010 Jul 12
TI  - The DNR Order: What Does it Mean?
PG  - 15-23
AB  - As medical science continues to advance, patients nowadays with progressive
      cardiopulmonary diseases live to older ages. However, they too will eventually
      reach their unsustainable physiological limit and many die in poor health and
      discomfort prior to their demise. Regrettably many physicians have not kept pace 
      in dealing with the inevitable end-of- life issues, along with modern
      technological developments. Without proper guidance, ill-informed patients often 
      face unnecessary anxiety, receive futile resuscitation at the expense of their
      dignity and public cost which has and will become increasingly overwhelming
      according to our current demographic trends. In any health care reform, experts
      often suggest that difficult questions will have to be asked but the solutions
      are at least partly in the logistical details. From time to time, we see an
      isolated "Do Not Resuscitate" or DNR order in the chart, which is not always
      followed by thoughtful discussion on the boundary of care, either simultaneously 
      or known to be followed up soon. This paper attempts to begin asking some of
      these difficult questions, point out the fallacies of this order and expose the
      weaknesses in the present state of entitlement by public demand if physicians
      retreats more from the discussion. The solution does not lie in asking the
      questions but in changing the practice pattern in real life on a continuous
      basis, hopefully to be eventually accepted by most, if not all.
FAU - Tsang, John Y C
AU  - Tsang JY
AD  - Division of Critical Care Medicine, Department of Medicine, University of British
      Columbia, Vancouver, Canada.
LA  - eng
PT  - Journal Article
DEP - 20100712
PL  - United States
TA  - Clin Med Insights Circ Respir Pulm Med
JT  - Clinical medicine insights. Circulatory, respiratory and pulmonary medicine
JID - 101537753
PMC - PMC2998928
OTO - NOTNLM
OT  - cardiopulmonary disease
OT  - critical care
OT  - end of life issues
OT  - epidemiology trends
OT  - ethics
OT  - health care policy
OT  - level of care
OT  - public health economics
EDAT- 2010/12/16 06:00
MHDA- 2010/12/16 06:01
CRDT- 2010/12/16 06:00
PHST- 2010/12/16 06:00 [entrez]
PHST- 2010/12/16 06:00 [pubmed]
PHST- 2010/12/16 06:01 [medline]
PST - epublish
SO  - Clin Med Insights Circ Respir Pulm Med. 2010 Jul 12;4:15-23.


PMID- 21157179
OWN - NLM
STAT- MEDLINE
DCOM- 20110727
LR  - 20190516
IS  - 1554-8619 (Electronic)
IS  - 1554-8600 (Linking)
VI  - 6
IP  - 12
DP  - 2010 Dec
TI  - The threat of vaccine associated poliomyelitis in India: medicolegal issues
      involved.
PG  - 1071-5
AB  - India is among the world's large reservoirs of wild poliovirus (WPV) with 559
      confirmed cases of poliomyelitis (wild virus) being reported in 2008. The World
      Health Organization's program for the eradication of poliomyelitis in third world
      countries like India is associated with major ethical and medico-legal
      implications. Two vaccines are available in India for poliomyelitis i.e. oral
      polio vaccine (OPV) and inactivated polio vaccine (IPV), of which OPV is used in 
      the eradication campaign, the case count for 2009 being 36 out of a total of 384 
      reported cases globally, the case count for mid 2010 being 19 cases out of 84
      reported globally. There are widespread reports of vaccine derived poliomyelitis 
      as well as vaccine associated poliomyelitis (VAP) from different parts of the
      country, which can be linked to resurgence of polio in several states or to the
      failure of the polio drive (Polio Sundays). Though an extended comprehensive
      polio campaign is on and both money and manpower are being dumped for achieving
      the goal of polio eradication, the ground reality is entirely different. The
      argument that wild polio strains have surfaced to hamper the drive cannot account
      for all post vaccination cases. The Indian Academy of Paediatrics has forcefully 
      suggested replacement of OPV by IPV, as the effectiveness of IPV far exceeds the 
      cost benefit of OPV. IPV has by and large replaced OPV in many parts of the
      world. The second issue is the threat of litigation on the health department once
      the post vaccination cases rise even further. There are certain other
      socio-ethical issues discussed in this paper on a subject which has an important 
      bearing on the health statistics of this country.
FAU - Rajput, Meena
AU  - Rajput M
AD  - Department of Community Medicine, Pt. B. D. Sharma Post-Graduate Institute of
      Medical Sciences, University of Health Sciences, Rohtak, Haryana, India.
FAU - Sharma, Luv
AU  - Sharma L
LA  - eng
PT  - Journal Article
DEP - 20101201
PL  - United States
TA  - Hum Vaccin
JT  - Human vaccines
JID - 101265291
RN  - 0 (Poliovirus Vaccines)
SB  - IM
MH  - Humans
MH  - India
MH  - *Poliomyelitis
MH  - Poliovirus Vaccines/*adverse effects
MH  - Vaccination/*legislation & jurisprudence
EDAT- 2010/12/16 06:00
MHDA- 2011/07/28 06:00
CRDT- 2010/12/16 06:00
PHST- 2010/12/16 06:00 [entrez]
PHST- 2010/12/16 06:00 [pubmed]
PHST- 2011/07/28 06:00 [medline]
AID - 13354 [pii]
AID - 10.4161/hv.6.12.13354 [doi]
PST - ppublish
SO  - Hum Vaccin. 2010 Dec;6(12):1071-5. doi: 10.4161/hv.6.12.13354. Epub 2010 Dec 1.


PMID- 21157165
OWN - NLM
STAT- MEDLINE
DCOM- 20110527
LR  - 20151119
IS  - 2005-3673 (Print)
IS  - 2005-3673 (Linking)
VI  - 40
IP  - 5
DP  - 2010 Oct
TI  - [Development of dementia care standards].
PG  - 631-41
LID - 10.4040/jkan.2010.40.5.631 [doi]
AB  - PURPOSE: This study was done to develop standards for dementia care as a baseline
      for professional nurses to provide a framework for dementia care evaluation.
      METHODS: The dementia care standards were developed through a literature review
      and focus group discussions. According to the Delphi method, the data analysis
      was conducted using the Content Validity Index (CVI). RESULTS: The final set of
      18 standards on dementia care was developed through one round of CVI. The
      standards included four structural standards: 'Organization of nursing system',
      'Operating system', 'Management of human resources', 'Management of material
      resources', 13 procedural standards: 'Advanced assessment', 'Nursing diagnosis', 
      'Nursing plan', 'Advanced nursing implementation', 'Evaluation', 'Education',
      'Research', 'Consultation', 'Counseling and cooperation', 'Development of
      specialty', 'Utilizing resources', 'Nursing quality assurance', 'Ethics', and one
      standard concerning outcome ('Evaluation of nursing tasks in care of patients
      with dementia'). The final set of 55 criteria on care of patients with dementia
      was confirmed through two rounds of CVI. The final 171 indicators were confirmed 
      through four rounds of CVI. CONCLUSION: These dementia care standards provides a 
      framework that allows registered nurses to clarify their roles and tasks in the
      care of patients with dementia and provides evaluation criteria.
FAU - Ha, Ju Young
AU  - Ha JY
AD  - Pusan National University, Yangsan, Korea. jyha1028@pusan.ac.kr
LA  - kor
PT  - English Abstract
PT  - Journal Article
PL  - Korea (South)
TA  - J Korean Acad Nurs
JT  - Journal of Korean Academy of Nursing
JID - 101488689
SB  - IM
MH  - Dementia/*nursing
MH  - Humans
MH  - Nursing Care/*standards
MH  - Program Evaluation
MH  - Standard of Care
MH  - Surveys and Questionnaires
EDAT- 2010/12/16 06:00
MHDA- 2011/05/28 06:00
CRDT- 2010/12/16 06:00
PHST- 2010/12/16 06:00 [entrez]
PHST- 2010/12/16 06:00 [pubmed]
PHST- 2011/05/28 06:00 [medline]
AID - 201010631 [pii]
AID - 10.4040/jkan.2010.40.5.631 [doi]
PST - ppublish
SO  - J Korean Acad Nurs. 2010 Oct;40(5):631-41. doi: 10.4040/jkan.2010.40.5.631.


PMID- 21156933
OWN - NLM
STAT- MEDLINE
DCOM- 20110510
LR  - 20211020
IS  - 1942-3268 (Electronic)
IS  - 1942-3268 (Linking)
VI  - 3
IP  - 6
DP  - 2010 Dec
TI  - Ethical and practical guidelines for reporting genetic research results to study 
      participants: updated guidelines from a National Heart, Lung, and Blood Institute
      working group.
PG  - 574-80
LID - 10.1161/CIRCGENETICS.110.958827 [doi]
AB  - In January 2009, the National Heart, Lung, and Blood Institute convened a
      28-member multidisciplinary Working Group to update the recommendations of a 2004
      National Heart, Lung, and Blood Institute Working Group focused on Guidelines to 
      the Return of Genetic Research Results. Changes in the genetic and societal
      landscape over the intervening 5 years raise multiple questions and challenges.
      The group noted the complex issues arising from the fact that technological and
      bioinformatic progress has made it possible to obtain considerable information on
      individuals that would not have been possible a decade ago. Although unable to
      reach consensus on a number of issues, the working group produced 5
      recommendations. The working group offers 2 recommendations addressing the
      criteria necessary to determine when genetic results should and may be returned
      to study participants, respectively. In addition, it suggests that a time limit
      be established to limit the duration of obligation of investigators to return
      genetic research results. The group recommends the creation of a central body, or
      bodies, to provide guidance on when genetic research results are associated with 
      sufficient risk and have established clinical utility to justify their return to 
      study participants. The final recommendation urges investigators to engage the
      broader community when dealing with identifiable communities to advise them on
      the return of aggregate and individual research results. Creation of an entity
      charged to provide guidance to institutional review boards, investigators,
      research institutions, and research sponsors would provide rigorous review of
      available data, promote standardization of study policies regarding return of
      genetic research results, and enable investigators and study participants to
      clarify and share expectations for the handling of this increasingly valuable
      information with appropriate respect for the rights and needs of participants.
CN  - National Heart, Lung, and Blood Institute working group
AD  - Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute,
      Epidemiology Branch, 6701 Rockledge Drive/ MSC 7935, Bethesda, MD20892, USA.
      fabsitzr@nhlbi.nih.gov
FAU - Fabsitz, Richard R
AU  - Fabsitz RR
FAU - McGuire, Amy
AU  - McGuire A
FAU - Sharp, Richard R
AU  - Sharp RR
FAU - Puggal, Mona
AU  - Puggal M
FAU - Beskow, Laura M
AU  - Beskow LM
FAU - Biesecker, Leslie G
AU  - Biesecker LG
FAU - Bookman, Ebony
AU  - Bookman E
FAU - Burke, Wylie
AU  - Burke W
FAU - Burchard, Esteban Gonzalez
AU  - Burchard EG
FAU - Church, George
AU  - Church G
FAU - Clayton, Ellen Wright
AU  - Clayton EW
FAU - Eckfeldt, John H
AU  - Eckfeldt JH
FAU - Fernandez, Conrad V
AU  - Fernandez CV
FAU - Fisher, Rebecca
AU  - Fisher R
FAU - Fullerton, Stephanie M
AU  - Fullerton SM
FAU - Gabriel, Stacey
AU  - Gabriel S
FAU - Gachupin, Francine
AU  - Gachupin F
FAU - James, Cynthia
AU  - James C
FAU - Jarvik, Gail P
AU  - Jarvik GP
FAU - Kittles, Rick
AU  - Kittles R
FAU - Leib, Jennifer R
AU  - Leib JR
FAU - O'Donnell, Christopher
AU  - O'Donnell C
FAU - O'Rourke, P Pearl
AU  - O'Rourke PP
FAU - Rodriguez, Laura Lyman
AU  - Rodriguez LL
FAU - Schully, Sheri D
AU  - Schully SD
FAU - Shuldiner, Alan R
AU  - Shuldiner AR
FAU - Sze, Rebecca K F
AU  - Sze RK
FAU - Thakuria, Joseph V
AU  - Thakuria JV
FAU - Wolf, Susan M
AU  - Wolf SM
FAU - Burke, Gregory L
AU  - Burke GL
LA  - eng
GR  - HG004603/HG/NHGRI NIH HHS/United States
GR  - UL1 RR024128-01/RR/NCRR NIH HHS/United States
GR  - U01 HG004603-01/HG/NHGRI NIH HHS/United States
GR  - R01 HG003178/HG/NHGRI NIH HHS/United States
GR  - U01 HG004603/HG/NHGRI NIH HHS/United States
GR  - R01 HG003178-01A1/HG/NHGRI NIH HHS/United States
GR  - RR024128/RR/NCRR NIH HHS/United States
GR  - HG003178/HG/NHGRI NIH HHS/United States
GR  - UL1 RR024128/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Practice Guideline
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Circ Cardiovasc Genet
JT  - Circulation. Cardiovascular genetics
JID - 101489144
SB  - IM
MH  - Academies and Institutes
MH  - Ethics Committees, Research
MH  - Genetic Research/*ethics
MH  - Humans
MH  - National Heart, Lung, and Blood Institute (U.S.)
MH  - Policy
MH  - United States
PMC - PMC3090664
MID - NIHMS272954
EDAT- 2010/12/16 06:00
MHDA- 2011/05/11 06:00
CRDT- 2010/12/16 06:00
PHST- 2010/12/16 06:00 [entrez]
PHST- 2010/12/16 06:00 [pubmed]
PHST- 2011/05/11 06:00 [medline]
AID - 3/6/574 [pii]
AID - 10.1161/CIRCGENETICS.110.958827 [doi]
PST - ppublish
SO  - Circ Cardiovasc Genet. 2010 Dec;3(6):574-80. doi:
      10.1161/CIRCGENETICS.110.958827.


PMID- 21156919
OWN - NLM
STAT- MEDLINE
DCOM- 20110422
LR  - 20120718
IS  - 1943-3662 (Electronic)
IS  - 1093-6793 (Linking)
VI  - 38
IP  - 4
DP  - 2010
TI  - Howard Zonana and the transformation of forensic psychiatry.
PG  - 570-6
AB  - In recognition of Howard Zonana's contributions, I take stock of the progress of 
      the field of forensic psychiatry over three decades. As forensic psychiatrists,
      you are the voice of psychiatry in the law and the interpreter of law to your
      colleagues in psychiatry. I offer provisional impressions of your collective
      accomplishments under three themes: expertise, influence, and integrity. First,
      you have established and nurtured the expertise and authority of forensic
      psychiatry, which has become increasingly evidence-based and reflects a prudent
      sense of humility. Second, you have had a significant influence on the design and
      daily application of mental health law in both criminal and civil spheres.
      Through the American Academy of Psychiatry and the Law (AAPL) and relevant
      components of the American Psychological Association, you have been a strong and 
      effective advocate for protecting both the needs and rights of people with mental
      illness and have had demonstrable influence in the Supreme Court as well as at
      the grassroots. Finally, you have nurtured and protected the ethical integrity of
      the profession in the face of ever-increasing challenges, due in no small measure
      to the habits of ethical reflection that Howard Zonana has modeled and taught
      over the course of his extraordinary career.
FAU - Bonnie, Richard J
AU  - Bonnie RJ
AD  - University of Virginia School of Law, Charlottesville, VA 22903, USA.
      rbonnie@virginia.edu
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - J Am Acad Psychiatry Law
JT  - The journal of the American Academy of Psychiatry and the Law
JID - 9708963
SB  - IM
CIN - J Am Acad Psychiatry Law. 2012;40(2):246-52. PMID: 22635298
MH  - Forensic Psychiatry/ethics/*history/trends
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Professional Competence
MH  - United States
EDAT- 2010/12/16 06:00
MHDA- 2011/04/26 06:00
CRDT- 2010/12/16 06:00
PHST- 2010/12/16 06:00 [entrez]
PHST- 2010/12/16 06:00 [pubmed]
PHST- 2011/04/26 06:00 [medline]
AID - 38/4/570 [pii]
PST - ppublish
SO  - J Am Acad Psychiatry Law. 2010;38(4):570-6.


PMID- 21156917
OWN - NLM
STAT- MEDLINE
DCOM- 20110422
LR  - 20101215
IS  - 1943-3662 (Electronic)
IS  - 1093-6793 (Linking)
VI  - 38
IP  - 4
DP  - 2010
TI  - Coping with the ethical conundra of forensic psychiatry: a tribute to Howard
      Zonana, MD.
PG  - 551-8
AB  - As part of the Festschrift in honor of Howard Zonana, MD, this article reviews
      two important concerns that emerged in the ethics of forensic psychiatry in the
      resolution of which he played critical roles. In the late 1980s and early 1990s, 
      the question arose of what role, if any, was proper for psychiatrists to play
      with regard to evaluations of competence to be executed and treatment of
      incompetent prisoners. Dr. Zonana was a major force in developing the American
      Psychiatric Association's position, in which the rights of prisoners were
      balanced with protection of the integrity of the medical profession. He was then 
      deeply involved in helping to persuade the American Medical Association to reject
      a more extreme position and to adopt this approach. Similarly, in the mid-2000s, 
      Dr. Zonana brought to the attention of the American Psychiatric Association (APA)
      the participation of psychiatrists in interrogation of detainees in national
      security settings. The policy that he subsequently helped to craft was adopted by
      APA and influenced the subsequent, very similar AMA policy. These two examples,
      of the many that could have been chosen, illustrate the profound impact that
      Howard Zonana has had on the ethics of psychiatry as a whole and on the ethics of
      forensic psychiatry in particular.
FAU - Appelbaum, Paul S
AU  - Appelbaum PS
AD  - Division of Law, Ethics and Psychiatry, Columbia University, New York, NY, USA.
      psa21@columbia.edu
LA  - eng
PT  - Biography
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - J Am Acad Psychiatry Law
JT  - The journal of the American Academy of Psychiatry and the Law
JID - 9708963
SB  - IM
MH  - *Adaptation, Psychological
MH  - Forensic Psychiatry/*ethics
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Male
PS  - Zonana H
FPS - Zonana, Howard
EDAT- 2010/12/16 06:00
MHDA- 2011/04/26 06:00
CRDT- 2010/12/16 06:00
PHST- 2010/12/16 06:00 [entrez]
PHST- 2010/12/16 06:00 [pubmed]
PHST- 2011/04/26 06:00 [medline]
AID - 38/4/551 [pii]
PST - ppublish
SO  - J Am Acad Psychiatry Law. 2010;38(4):551-8.


PMID- 21156295
OWN - NLM
STAT- MEDLINE
DCOM- 20110509
LR  - 20211020
IS  - 1878-7452 (Electronic)
IS  - 1878-7452 (Linking)
VI  - 67
IP  - 6
DP  - 2010 Nov-Dec
TI  - Guidelines for maintaining a professional compass in the era of social
      networking.
PG  - 381-6
LID - 10.1016/j.jsurg.2010.07.006 [doi]
AB  - OBJECTIVES: The use of social networking (SN) sites, such as Facebook and
      Twitter, has skyrocketed during the past 5 years, with more than 400 million
      current users. What was once isolated to high schools or college campuses has
      become increasingly ubiquitous in everyday life and across a multitude of
      industries. Medical centers and residency programs are not immune to this
      invasion. These sites present opportunities for the rapid dissemination of
      information from status updates, to tweets, to medical support groups, and even
      clinical communication between patients and providers. Although powerful, this
      technology also opens the door for misuse and policies for use will be necessary.
      We strive to begin a discourse in the surgical community in regard to maintaining
      professionalism while using SN sites. RESULTS: The use of SN sites among surgical
      house staff and faculty has not been addressed previously. To that end, we sought
      to ascertain the use of the SN site Facebook at our residency program. Of 88
      residents and 127 faculty, 56 (64%) and 28 (22%), respectively, have pages on
      Facebook. Of these, 50% are publicly accessible. Thirty-one percent of the
      publicly accessible pages had work-related comments posted, and of these
      comments, 14% referenced specific patient situations or were related to patient
      care. CONCLUSIONS: Given the widespread use of SN websites in our surgical
      community and in society as a whole, every effort should be made to guard against
      professional truancy. We offer a set of guidelines consistent with the
      Accreditation Council for Graduate Medical Education and the American College of 
      Surgeons professionalism mandates in regard to usage of these websites. By
      acknowledging this need and by following these guidelines, surgeons will continue
      to define and uphold ethical boundaries and thus demonstrate a commitment to
      patient privacy and the highest levels of professionalism.
CI  - Copyright (c) 2010 Association of Program Directors in Surgery. Published by
      Elsevier Inc. All rights reserved.
FAU - Landman, Matthew P
AU  - Landman MP
AD  - Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee
      37232-2730, USA.
FAU - Shelton, Julia
AU  - Shelton J
FAU - Kauffmann, Rondi M
AU  - Kauffmann RM
FAU - Dattilo, Jeffery B
AU  - Dattilo JB
LA  - eng
GR  - T32 DK007061/DK/NIDDK NIH HHS/United States
GR  - T32 HS013833-08/HS/AHRQ HHS/United States
GR  - 5T32DK007061-35/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20101105
PL  - United States
TA  - J Surg Educ
JT  - Journal of surgical education
JID - 101303204
SB  - IM
MH  - Academic Medical Centers
MH  - Adult
MH  - Cross-Sectional Studies
MH  - Faculty, Medical/statistics & numerical data
MH  - Female
MH  - General Surgery/*standards
MH  - *Guidelines as Topic
MH  - Humans
MH  - Internet/*standards/statistics & numerical data
MH  - Internship and Residency/statistics & numerical data
MH  - Male
MH  - Middle Aged
MH  - Professional Competence
MH  - *Social Support
MH  - Surveys and Questionnaires
MH  - Tennessee
PMC - PMC4000745
MID - NIHMS566448
EDAT- 2010/12/16 06:00
MHDA- 2011/05/10 06:00
CRDT- 2010/12/16 06:00
PHST- 2010/04/17 00:00 [received]
PHST- 2010/07/08 00:00 [accepted]
PHST- 2010/12/16 06:00 [entrez]
PHST- 2010/12/16 06:00 [pubmed]
PHST- 2011/05/10 06:00 [medline]
AID - S1931-7204(10)00186-8 [pii]
AID - 10.1016/j.jsurg.2010.07.006 [doi]
PST - ppublish
SO  - J Surg Educ. 2010 Nov-Dec;67(6):381-6. doi: 10.1016/j.jsurg.2010.07.006. Epub
      2010 Nov 5.


PMID- 21154213
OWN - NLM
STAT- MEDLINE
DCOM- 20110429
LR  - 20101214
IS  - 1438-9592 (Electronic)
IS  - 0044-409X (Linking)
VI  - 135
IP  - 6
DP  - 2010 Dec
TI  - [Palliative medicine and inpatient palliative care unit--functions, organisation 
      forms and significance of surgery].
PG  - 547-55
LID - 10.1055/s-0030-1262624 [doi]
AB  - About 160 palliative care units with 1228 beds or 15 beds / 1 million inhabitants
      were available in German hospitals in the year 2008. Demand analyses consider 35 
      beds / 1 million inhabitants as necessary. Whether the additional demand could be
      reduced by a greater use of home- and hospice-based end-of-life care is
      discussed. For general hospitals the establishment of an acute palliative care
      unit within a medical (oncology) ward is recommended due to costs, organisation
      facilities and attitudes of physicians toward referral. The establishment of an
      acute palliative care unit may be costly for the hospital, nevertheless,
      outpatient palliative medicine and hospices are a cost-effective health service
      from a socioeconomic point of view, avoiding unnecessary hospital admissions and 
      freeing up hospital beds by early discharge. An analysis of consultants
      demonstrates a minor interest of surgeons in specialisation in palliative
      medicine. However, data suggest that prior experience in palliative care alters
      the selection of treatment recommendations by surgeons with respect to more
      supportive or aggressive interventions in patients with advanced cancer. Ethical 
      decision-making regarding therapy and counselling of patients at the end of life 
      and discussing the prognosis with patients and their families require education
      in palliative medicine. A core curriculum to teach palliative care for surgical
      residents therefore has been presented.
CI  - (c) Georg Thieme Verlag KG Stuttgart New York.
FAU - Grundmann, R T
AU  - Grundmann RT
AD  - Burghausen, Deutschland (vormals: Kreiskliniken Altotting-Burghausen).
      reinhart@prof-grundmann.de
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Palliativmedizin und Palliativstation--Aufgaben, Organisationsformen und
      Bedeutung fur die Chirurgie.
DEP - 20101213
PL  - Germany
TA  - Zentralbl Chir
JT  - Zentralblatt fur Chirurgie
JID - 0413645
SB  - IM
MH  - Cost-Benefit Analysis
MH  - Germany
MH  - Home Care Services/economics/organization & administration
MH  - Hospice Care/economics/organization & administration
MH  - *Hospital Bed Capacity/economics
MH  - Humans
MH  - National Health Programs/economics
MH  - Neoplasms/economics/*surgery
MH  - Oncology Service, Hospital/economics/*organization & administration
MH  - Palliative Care/*methods
MH  - Terminal Care/economics/organization & administration
EDAT- 2010/12/15 06:00
MHDA- 2011/04/30 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/04/30 06:00 [medline]
AID - 10.1055/s-0030-1262624 [doi]
PST - ppublish
SO  - Zentralbl Chir. 2010 Dec;135(6):547-55. doi: 10.1055/s-0030-1262624. Epub 2010
      Dec 13.


PMID- 21154132
OWN - NLM
STAT- MEDLINE
DCOM- 20110502
LR  - 20181201
IS  - 2040-3410 (Electronic)
IS  - 1369-7056 (Linking)
VI  - 13
IP  - 12
DP  - 2010 Dec
TI  - 2010 World Stem Cell Summit--part 1. October 4-6, 2010, Detroit, MI, USA.
PG  - 819-21
AB  - The 2010 World Stem Cell Summit, held in Detroit, included topics covering new
      developments in the field of regenerative medicine. This conference report
      highlights selected presentations on government support for stem cell research in
      Michigan, financing stem cell development, regulatory and ethical considerations,
      Pharma's interest in allogeneic cell therapies, and the US Armed forces
      investment in regenerative medicine.
FAU - Vertes, Alain
AU  - Vertes A
AD  - London Business School, Regent's Park, London, NW1 4SA, UK.
      avertes.sln2004@london.edu
LA  - eng
PT  - Congress
PL  - England
TA  - IDrugs
JT  - IDrugs : the investigational drugs journal
JID - 100883655
SB  - IM
MH  - Animals
MH  - Humans
MH  - Internationality
MH  - Regenerative Medicine/economics/methods/trends
MH  - *Stem Cell Research/economics/ethics/legislation & jurisprudence
MH  - Stem Cell Transplantation/trends
MH  - *Stem Cells/drug effects/metabolism
EDAT- 2010/12/15 06:00
MHDA- 2011/05/03 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/05/03 06:00 [medline]
PST - ppublish
SO  - IDrugs. 2010 Dec;13(12):819-21.


PMID- 21153933
OWN - NLM
STAT- MEDLINE
DCOM- 20110915
LR  - 20181201
IS  - 2458-9446 (Electronic)
IS  - 1300-0012 (Linking)
VI  - 22
IP  - 4
DP  - 2010 Oct
TI  - [Assessment of the effect of intrathecal levobupivacaine combined with fentanyl
      or morphine on postoperative analgesia in patients undergoing cesarean section].
PG  - 151-8
AB  - OBJECTIVES: Our prospective, randomized, double-blind study aimed to detect the
      effect of intrathecal levobupivacaine combined with fentanyl or morphine on the
      postoperative analgesia in patients undergoing cesarean section. METHODS: After
      approval by the hospital ethics committee and obtaining written informed consent,
      ASA I-II parturients undergoing elective cesarean section were enrolled in this
      study. None of the patients had any contraindication for spinal anesthesia or
      sensitivity to local anesthetics. Patients were randomly assigned in a
      double-blinded fashion to receive either intrathecal 10 mg 5% levobupivacaine +
      0.1 mg morphine (Group M, n=30) or 10 mg 5% levobupivacaine + 20 mcg fentanyl
      (Group F, n=30). The onset of sensorial block and anesthesia, interval of
      effective analgesia until the first analgesic requirement, disappearance of motor
      block according to modified Bromage scale, duration of spinal analgesia,
      additional analgesic requirement, amount of additional analgesic, adverse
      effects, and postoperative patient satisfaction were recorded. RESULTS: The
      additional analgesic requirement period was significantly longer in Group M than 
      Group F (p<0.001). Intraoperative and postoperative complications were
      significantly higher in Group F than Group M (p<0.05). Intended, delivered and
      total analgesic amount values were significantly higher in Group F than Group M
      (p<0.001). Patient satisfaction and presentation elsewhere were significantly
      higher in Group M than Group F (p<0.01). CONCLUSION: Despite more adverse
      effects, additional analgesic requirement is lower in Group M, and the long-term 
      painless postoperative period accounts for the choice by mothers.
FAU - Acar, Pinar
AU  - Acar P
AD  - Department of Anesthesiology, Istanbul Education and Training Hospital, Istanbul,
      Turkey.
FAU - Ozyuvaci, Emine
AU  - Ozyuvaci E
FAU - Vatansever, Sule
AU  - Vatansever S
FAU - Toprak, Naile
AU  - Toprak N
FAU - Akyol, Onat
AU  - Akyol O
LA  - tur
PT  - Journal Article
PT  - Randomized Controlled Trial
TT  - Sezaryenlerde intratekal levobupivakaine ilave edilen fentanil ve morfinin
      postoperatif agri uzerine etkisinin degerlendirilmesi.
PL  - Turkey
TA  - Agri
JT  - Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish
      Society of Algology
JID - 9426197
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Anesthetics, Local)
RN  - 76I7G6D29C (Morphine)
RN  - A5H73K9U3W (Levobupivacaine)
RN  - UF599785JZ (Fentanyl)
RN  - Y8335394RO (Bupivacaine)
SB  - IM
MH  - Adult
MH  - Analgesics, Opioid/administration & dosage
MH  - Anesthesia, Spinal/*standards
MH  - Anesthetics, Local/*administration & dosage
MH  - Bupivacaine/administration & dosage/analogs & derivatives
MH  - *Cesarean Section
MH  - Double-Blind Method
MH  - Female
MH  - Fentanyl/administration & dosage
MH  - Humans
MH  - Injections, Spinal
MH  - Levobupivacaine
MH  - Morphine/administration & dosage
MH  - Pain, Postoperative/drug therapy/*prevention & control
MH  - Pregnancy
MH  - Prospective Studies
EDAT- 2010/12/15 06:00
MHDA- 2011/09/16 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/09/16 06:00 [medline]
PST - ppublish
SO  - Agri. 2010 Oct;22(4):151-8.


PMID- 21152829
OWN - NLM
STAT- MEDLINE
DCOM- 20111114
LR  - 20190918
IS  - 1806-9282 (Electronic)
IS  - 0104-4230 (Linking)
VI  - 56
IP  - 5
DP  - 2010 Sep-Oct
TI  - Informed consent and research with stored biological samples.
PG  - 563-7
LID - S0104-42302010000500018 [pii]
AB  - OBJECTIVE: To report practical experience in obtaining consent for a
      retrospective study conducted at the Brazilian National Cancer Institute (INCA). 
      The study involved review of medical records and analysis of paraffin blocks of
      patients surgically treated for colon cancer between 2000 and 2004. Attempts to
      obtain informed consent were made in compliance with the resolution 196/96 of the
      Brazilian National Health Council and determination of INCA Research Ethics
      Committee. METHODS: At scheduled appointments, we could approach only four
      patients for consent during three months. After attempting contact by phone, an
      information sheet summarizing the content of informed consent, two copies of the 
      consent form and a prepaid return envelope were then mailed to the patients.
      RESULTS: Of the 155 consent forms mailed, 115 were returned (74%). Of these, 111 
      patients gave consent to participate in the study, one refused consent, and we
      were informed that three patients had died. The time course of return of these
      forms ranged from 2 to 89 days (median: 10 days). Attempts to contact patients by
      phone were successful in 60 out of 160 cases (37.5%). The Research Ethics
      Committee waived the requirement of consent for those who had died or not
      responded. Overall mailing cost was R$ 1,004.40. CONCLUSION: Obtaining consent
      from patients by phone and mail for a retrospective clinical study is feasible.
      Most patients responded to contact and gave consent to participate. However, the 
      process entails costs and risks that cannot be overlooked.
FAU - Duque, Cristiano Guedes
AU  - Duque CG
AD  - Instituto Nacional de Cancer - INCA MS/HC1, Rio de Janeiro, RJ, Brazil.
FAU - Ramalho, Daniela Maria de Paula
AU  - Ramalho DM
FAU - Casali-da-Rocha, Jose Claudio
AU  - Casali-da-Rocha JC
LA  - eng
LA  - por
PT  - Journal Article
PL  - Brazil
TA  - Rev Assoc Med Bras (1992)
JT  - Revista da Associacao Medica Brasileira (1992)
JID - 9308586
SB  - IM
MH  - *Biological Specimen Banks
MH  - Humans
MH  - Informed Consent/*standards/*statistics & numerical data
MH  - *Interviews as Topic/statistics & numerical data
MH  - *Postal Service/economics/statistics & numerical data
MH  - Time Factors
EDAT- 2010/12/15 06:00
MHDA- 2011/11/15 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/05/10 00:00 [received]
PHST- 2010/07/11 00:00 [accepted]
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/11/15 06:00 [medline]
AID - S0104-42302010000500018 [pii]
AID - 10.1590/s0104-42302010000500018 [doi]
PST - ppublish
SO  - Rev Assoc Med Bras (1992). 2010 Sep-Oct;56(5):563-7. doi:
      10.1590/s0104-42302010000500018.


PMID- 21152747
OWN - NLM
STAT- MEDLINE
DCOM- 20110330
LR  - 20191111
IS  - 1726-4642 (Electronic)
IS  - 1726-4634 (Linking)
VI  - 27
IP  - 3
DP  - 2010 Sep
TI  - [What happens with the Peruvian ethical review board?].
PG  - 482
LID - S1726-46342010000300027 [pii]
FAU - Zavala, Salomon
AU  - Zavala S
LA  - spa
PT  - Letter
TT  - inverted question markQue pasa con los comites de etica de investigacion
      peruanos?
PL  - Peru
TA  - Rev Peru Med Exp Salud Publica
JT  - Revista peruana de medicina experimental y salud publica
JID - 101227566
SB  - IM
MH  - *Ethics Committees, Research
MH  - Peru
EDAT- 2010/12/15 06:00
MHDA- 2011/03/31 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/03/31 06:00 [medline]
AID - S1726-46342010000300027 [pii]
AID - 10.1590/s1726-46342010000300027 [doi]
PST - ppublish
SO  - Rev Peru Med Exp Salud Publica. 2010 Sep;27(3):482. doi:
      10.1590/s1726-46342010000300027.


PMID- 21152739
OWN - NLM
STAT- MEDLINE
DCOM- 20110330
LR  - 20191111
IS  - 1726-4642 (Electronic)
IS  - 1726-4634 (Linking)
VI  - 27
IP  - 3
DP  - 2010 Sep
TI  - [Why to audit to research ethics committees?].
PG  - 443-8
LID - S1726-46342010000300019 [pii]
AB  - Ethics committees in biomedical research have the responsibility to ensure the
      protection of human participants in the studies. In order to improve the quality 
      of their work they must undergo audit procedures commissioned by the sponsors and
      inspections done by the regulatory authorities. Through these procedures,
      improvement of their functions should be guaranteed, so they can optimize their
      tasks and accomplish in the best way the purpose for which they were created.
FAU - Quiroz, Estela
AU  - Quiroz E
AD  - Hospital Nacional Hipolito Unanue, Lima, Peru. esteliqm@yahoo.com
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - inverted question markPor que auditar a los comites de etica en investigacion?
PL  - Peru
TA  - Rev Peru Med Exp Salud Publica
JT  - Revista peruana de medicina experimental y salud publica
JID - 101227566
SB  - IM
MH  - Ethics Committees, Research/*standards
MH  - Humans
MH  - *Management Audit
MH  - Quality Control
EDAT- 2010/12/15 06:00
MHDA- 2011/03/31 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/03/31 06:00 [medline]
AID - S1726-46342010000300019 [pii]
AID - 10.1590/s1726-46342010000300019 [doi]
PST - ppublish
SO  - Rev Peru Med Exp Salud Publica. 2010 Sep;27(3):443-8. doi:
      10.1590/s1726-46342010000300019.


PMID- 21152738
OWN - NLM
STAT- MEDLINE
DCOM- 20110330
LR  - 20191111
IS  - 1726-4642 (Electronic)
IS  - 1726-4634 (Linking)
VI  - 27
IP  - 3
DP  - 2010 Sep
TI  - [Reflections about research ethics in humans].
PG  - 438-42
LID - S1726-46342010000300018 [pii]
AB  - In order to propose the necessary moral reflection about the personal
      responsibility that each researcher assumes when he performs scientific research 
      in human beings, an essay of moral and scientific themes is presented, using
      information from the relevant scientific and ethical literature. Around the
      concepts of heteronymous and autonomous ethics, it is proposed that ultimately
      and beyond informed consent and training courses on research ethics, the behavior
      of the researcher will depend on his/her own moral responsibility, tested in
      different situational contexts. Two explanatory models are used in order to
      understand this dynamic, the one of normality in mental health and the one of
      moral development of men. We conclude that the research process in human beings
      is a scientific and moral activity that, depending in various situations of
      conflicts of interest, will always test the researcher's moral controls.
FAU - Perales, Alberto
AU  - Perales A
AD  - Instituto de Etica en Salud, Facultad de Medicina, Universidad Nacional Mayor de 
      San Marcos, Lima, Peru. perales.alberto@gmail.com.pe
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Reflexiones sobre etica de investigacion en seres humanos.
PL  - Peru
TA  - Rev Peru Med Exp Salud Publica
JT  - Revista peruana de medicina experimental y salud publica
JID - 101227566
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Humans
EDAT- 2010/12/15 06:00
MHDA- 2011/03/31 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/03/31 06:00 [medline]
AID - S1726-46342010000300018 [pii]
AID - 10.1590/s1726-46342010000300018 [doi]
PST - ppublish
SO  - Rev Peru Med Exp Salud Publica. 2010 Sep;27(3):438-42. doi:
      10.1590/s1726-46342010000300018.


PMID- 21152706
OWN - NLM
STAT- MEDLINE
DCOM- 20110510
LR  - 20190606
IS  - 1518-8787 (Electronic)
IS  - 0034-8910 (Linking)
VI  - 45
IP  - 1
DP  - 2011 Feb
TI  - Ethics in the publication of studies on human visceral leishmaniasis in Brazilian
      periodicals.
PG  - 166-72
LID - S0034-89102010005000053 [pii]
AB  - OBJECTIVE: To analyze ethical aspects of Brazilian articles on human visceral
      leishmaniasis, published after Resolution CNS 196/1996, and to analyze the policy
      on Brazilian periodicals on research ethics. METHODS: An explanatory study with a
      bibliographical and documental nature was conducted. Selection of publications on
      research involving human beings since 1996 was performed in the SciELO Brazil
      database. Gaps associated with editorial policies on medical periodicals, based
      on information obtained from the "Instructions to authors" section of each
      periodical, were analyzed. RESULTS: While there were no articles on the
      compliance with ethical aspects in the first four-year period (from 1997 to
      2000), 75% fulfilled at least one of the ethical requirements evaluated in the
      first year (2009) of a subsequent four-year period (from 2009 to 2012). A total
      of six out of 11 periodicals indicated that the information about ethical aspects
      should be mentioned in the body of the article. There were three periodicals that
      required a letter or document, informing about compliance with these aspects and 
      signed by the author(s), to be sent; two that requested a copy of the document
      used to obtain the free and informed consent; one that clarified the need of a
      copy to authorize the approval by the Committee on Ethics in Research; and four
      in which no requirements of ethical aspects were found. CONCLUSIONS: There was an
      improvement in the description of compliance with ethical aspects found in
      articles. Standardization of ethical requirements for human research in Brazilian
      periodicals is suggested. This could promote compliance with the presuppositions 
      of documents regulating human research.
FAU - Malafaia, Guilherme
AU  - Malafaia G
AD  - Departamento de Ciencias Biologicas, Nucleo de Pesquisa em Ciencias Ambientais e 
      Biologicas, Instituto Federal de Educacao, Ciencia e Tecnologia Goiano, Urutai,
      GO, Brasil. guilhermebioufop@yahoo.com.br
FAU - Rodrigues, Aline Sueli de Lima
AU  - Rodrigues AS
FAU - Talvani, Andre
AU  - Talvani A
LA  - eng
LA  - por
PT  - Journal Article
DEP - 20101210
PL  - Brazil
TA  - Rev Saude Publica
JT  - Revista de saude publica
JID - 0135043
SB  - IM
MH  - Brazil
MH  - Human Experimentation/*legislation & jurisprudence
MH  - Humans
MH  - *Leishmaniasis, Visceral
MH  - Periodicals as Topic/*ethics/statistics & numerical data
MH  - Publishing/*ethics/legislation & jurisprudence
EDAT- 2010/12/15 06:00
MHDA- 2011/05/11 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/02/02 00:00 [received]
PHST- 2010/07/28 00:00 [accepted]
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/05/11 06:00 [medline]
AID - S0034-89102010005000053 [pii]
AID - 10.1590/s0034-89102010005000053 [doi]
PST - ppublish
SO  - Rev Saude Publica. 2011 Feb;45(1):166-72. doi: 10.1590/s0034-89102010005000053.
      Epub 2010 Dec 10.


PMID- 21152676
OWN - NLM
STAT- MEDLINE
DCOM- 20110823
LR  - 20140730
IS  - 0720-9355 (Print)
IS  - 0720-9355 (Linking)
VI  - 31
IP  - 2
DP  - 2011 May 2
TI  - [Role of thrombelastometry for the monitoring of factor XIII. A prospective
      observational study in neurosurgical patients].
PG  - 111-7
LID - 10.5482/ha-1132 [doi]
AB  - UNLABELLED: Recently published studies give evidence, that an increased maximum
      lysis in the APTEM(R) - test (ML60 > 12%) of the ROTEM(R) (Tem International
      GmbH, Munich, Germany) might indicate a factor XIII deficiency (FXIII < 70%). It 
      was the aim of this study to investigate the feasibility of thrombelastometric
      measurements with the ROTEM device to reflect the isolated influence of FXIII on 
      clot stability and therefore to indicate potential factor XIII deficiencies.
      PATIENTS, METHOD: After approval by the local Scientific and Ethic Review Board, 
      26 consecutive patients, scheduled for elective craniotomy for tumour resection, 
      were prospectively enrolled into this study. Blood samples were taken for
      conventional laboratory coagulation analyses, FXIII analyses and
      thrombelastometric measurements (EXTEM, FIBTEM and APTEM tests) after induction
      of general anaesthesia (T1), before skin incision (T2) as well as at (T3) and 24 
      hours after (T4) postoperative admission to ICU, respectively. Statistical
      analyses included Spearman rank order correlations and multiple linear
      regressions. RESULTS: FXIII concentrations did not correlate with the ML60 in the
      APTEM test at any measuring point. Neither platelet count nor fibrinogen nor
      FXIII concentrations were of predictive value for ML60 of the APTEM test.
      CONCLUSION: The results lead to the assumption that thrombelastometric
      measurements may not be appropriate for the perioperative monitoring of FXIII
      concentration.
FAU - Weber, C F
AU  - Weber CF
AD  - Klinik fur Anasthesiologie, Intensivmedizin u. Schmerztherapie, Klinikum der
      J.-W.-Goethe-Universitat Theodor-Stern-Kai 7, 60590 Frankfurt am Main.
      christian.weber@kgu.de
FAU - Sanders, J O
AU  - Sanders JO
FAU - Friedrich, K
AU  - Friedrich K
FAU - Gerlach, R
AU  - Gerlach R
FAU - Platz, J
AU  - Platz J
FAU - Miesbach, W
AU  - Miesbach W
FAU - Hanke, A A
AU  - Hanke AA
FAU - Hofstetter, C
AU  - Hofstetter C
LA  - ger
PT  - Clinical Trial
PT  - English Abstract
PT  - Journal Article
TT  - Stellenwert der Thrombelastometrie fur das Monitoring von Faktor XIII.
      Prospektive Observationsstudie bei neurochirurgischen Patienten.
DEP - 20101209
PL  - Germany
TA  - Hamostaseologie
JT  - Hamostaseologie
JID - 8204531
RN  - 9013-56-3 (Factor XIII)
SB  - IM
MH  - Brain Neoplasms/blood/*surgery
MH  - *Craniotomy
MH  - Factor XIII/*analysis
MH  - Factor XIII Deficiency/blood/*diagnosis
MH  - Feasibility Studies
MH  - Humans
MH  - Predictive Value of Tests
MH  - Preoperative Care
MH  - Prospective Studies
MH  - Thrombelastography/*instrumentation
EDAT- 2010/12/15 06:00
MHDA- 2011/08/24 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/08/24 06:00 [medline]
AID - 1132 [pii]
AID - 10.5482/ha-1132 [doi]
PST - ppublish
SO  - Hamostaseologie. 2011 May 2;31(2):111-7. doi: 10.5482/ha-1132. Epub 2010 Dec 9.


PMID- 21152239
OWN - NLM
STAT- MEDLINE
DCOM- 20110317
LR  - 20211020
IS  - 1178-1998 (Electronic)
IS  - 1176-9092 (Linking)
VI  - 5
DP  - 2010 Dec 2
TI  - Clinical intervention in aging: ethicolegal issues in assessing risk and benefit.
PG  - 373-80
LID - 10.2147/CIA.S15001 [doi]
AB  - The ethical dimension of treating the elderly, including risk-benefit analysis,
      focuses mainly on quality of life and end-of-life issues. These include arguments
      on advance directives and the concept of extraordinary treatments. This paper
      looks more closely at the philosophical approach to aging in order to address
      questions on the direction of research and issues such as longevity and social
      construction of the aging process. It is the way society moves to understand the 
      value-laden choices on aging that directs the goals of treatment and research.
      Whilst these vary culturally, one has to reckon with a postmodern view of aging
      which may, in turn, reflect on the course of action of future care and research
      in aging. The paper canvasses how, in reality, four principles act as guidelines 
      for moral discourse, and discusses how changing values in society decide this
      course of action.
FAU - Mallia, Pierre
AU  - Mallia P
AD  - Medical School, University of Malta, Mater Dei Hospital, Malta.
      pierre.mallia@um.edu.mt
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20101202
PL  - New Zealand
TA  - Clin Interv Aging
JT  - Clinical interventions in aging
JID - 101273480
SB  - IM
MH  - *Advance Directives
MH  - Aging/*ethics
MH  - Conflict, Psychological
MH  - Decision Making/*ethics
MH  - Female
MH  - Humans
MH  - Male
MH  - Risk Assessment/ethics
PMC - PMC2998245
OTO - NOTNLM
OT  - aging
OT  - clinical decision-making
OT  - conflict
OT  - decision-making
OT  - principles
OT  - social construction
OT  - treatment
EDAT- 2010/12/15 06:00
MHDA- 2011/03/18 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/03/18 06:00 [medline]
AID - 10.2147/CIA.S15001 [doi]
PST - epublish
SO  - Clin Interv Aging. 2010 Dec 2;5:373-80. doi: 10.2147/CIA.S15001.


PMID- 21151487
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 1878-5077 (Print)
IS  - 1878-5077 (Linking)
VI  - 1
IP  - 3
DP  - 2010 Sep
TI  - "First do no harm" and the importance of prediction in oncology.
PG  - 369-375
AB  - Present cancer treatment strategies are based on the assumption that a therapy
      may work ("response") or not work ("no-response"). However, the existing evidence
      suggests that current cancer treatment modalities may also have a
      cancer-promoting effect in part of the patients. In this paper, some relevant
      data are reviewed suggesting that surgery, irradiation, chemotherapy and
      immunotherapy can stimulate tumor growth / metastatic spread and decrease
      survival of patients in certain subgroups. Thus, results of cancer treatment may 
      be improved by detection and use of biomarkers that correlate with positive or
      negative therapeutic effects. Small trials based on groups with differing
      biomarkers rather than large phase III trials may aid the development and
      efficacy testing of new anticancer drugs. Moreover, ignoring biomarkers that
      correlate with positive or negative therapeutic effect may not be compatible
      anymore with the ethical principle "First Do No Harm".
FAU - Characiejus, Dainius
AU  - Characiejus D
FAU - Hodzic, Jasmina
AU  - Hodzic J
FAU - Jacobs, John J L
AU  - Jacobs JJ
LA  - eng
PT  - Journal Article
DEP - 20100717
PL  - Switzerland
TA  - EPMA J
JT  - The EPMA journal
JID - 101517307
PMC - PMC2987560
EDAT- 2010/12/15 06:00
MHDA- 2010/12/15 06:01
CRDT- 2010/12/15 06:00
PHST- 2010/06/16 00:00 [received]
PHST- 2010/07/02 00:00 [accepted]
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2010/12/15 06:01 [medline]
AID - 10.1007/s13167-010-0042-1 [doi]
PST - ppublish
SO  - EPMA J. 2010 Sep;1(3):369-375. doi: 10.1007/s13167-010-0042-1. Epub 2010 Jul 17.


PMID- 21151403
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1718-7729 (Electronic)
IS  - 1198-0052 (Linking)
VI  - 17
IP  - 6
DP  - 2010 Nov
TI  - Consent to external-beam radiotherapy.
PG  - 9-11
AB  - Canadian law, and the physician's code of ethics, requires that informed consent 
      be obtained before any medical act is performed. However, there are no rules
      about how consent is to be obtained and by whom, and how that consent is to be
      documented.In April 2008, we asked the heads of all Canadian radiation oncology
      departments to tell us whether their centre uses a written consent form for
      external-beam radiotherapy and, if it did, to send us a copy of the form or forms
      used. Responses were received from 29 of the 38 centres contacted (76%). In 12
      centres, all of them in British Columbia or Quebec, no written consent is
      obtained. Of the 17 centres (59%) that do seek written consent, 9 use a generic
      hospital or cancer centre form. Only 5 use a form specific to radiotherapy that
      mentions multiple visits, photographs in the treatment position, use of tattoos, 
      and so on, and only 2 use a form that is specific to the tumour type or site
      irradiated and that explains the risks associated with treatment. The final
      centre of the 17 did not provide a form for review.While current practice at the 
      McGill University Health Centre is not out of line with that at other Canadian
      centres, the results of our survey suggest a need for dialogue on the subject of 
      consent for external-beam radiotherapy.
FAU - Freeman, C
AU  - Freeman C
AD  - Department of Radiation Oncology, McGill University Health Centre, Montreal, QC.
FAU - Lamed, H
AU  - Lamed H
FAU - Gingras, C
AU  - Gingras C
FAU - Shenouda, G
AU  - Shenouda G
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Curr Oncol
JT  - Current oncology (Toronto, Ont.)
JID - 9502503
PMC - PMC2993450
OTO - NOTNLM
OT  - Radiotherapy
OT  - consent
EDAT- 2010/12/15 06:00
MHDA- 2010/12/15 06:01
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2010/12/15 06:01 [medline]
AID - 10.3747/co.v17i6.638 [doi]
PST - ppublish
SO  - Curr Oncol. 2010 Nov;17(6):9-11. doi: 10.3747/co.v17i6.638.


PMID- 21150851
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20151119
IS  - 1827-1596 (Electronic)
IS  - 0375-9393 (Linking)
VI  - 77
IP  - 2
DP  - 2011 Feb
TI  - Prehospital emergency physicians' experiences with advance directives in Germany:
      a questionnaire-based multicenter study.
PG  - 172-9
AB  - BACKGROUND: Palliative medical emergencies and end-of-life decisions resulting
      from the exacerbation of cancer account for approximately 3% of all
      out-of-hospital emergency applications in Germany. Therefore, prehospital
      emergency physicians (EP) may be confronted with advance directives and ethical
      and end-of-life decisions. The purpose of the study was to identify EPs'
      knowledge about ethical and end-of-life decisions and their legal education and
      experiences concerning advance directives. METHODS: Over a six-month period, we
      questioned all 150 EPs from three emergency medical services (Braunschweig,
      Gottingen und Kaiserslautern). An anonymous, self-administered questionnaire with
      a mixed-methods design was used. The main outcome measures included responses
      regarding experiences related to advance directives and end-of-life decisions in 
      palliative care patients. For statistical assessment, EPs were divided into three
      categories: competent, skilled, and unskilled. RESULTS: A total of 104 EPs
      returned the questionnaire (response rate 69%). Eighty-nine percent of the
      respondents treated patients who had advance directives. The existence of an
      advance directive influenced the EP's therapy decision in about 77% of their
      encounters. Eighty-seven percent of the EPs reported the need for defined
      end-of-life care pathways and/or standard operating procedures. Eighty-two
      percent desired educational training concerning end-of-life decisions and the
      validity of advance directives. CONCLUSION: The prehospital emergency treatment
      of palliative care patients can be particularly challenging for any EP. A high
      percentage of the EPs in our study felt insecure in dealing with advance
      directives and ethical and end-of-life decisions in palliative care patients. Our
      results suggest that EPs may need more information and education about palliative
      medical care, legal issues and ethical and end-of-life decisions to provide
      adequate patient-oriented palliative care in prehospital emergency situations.
FAU - Wiese, C H R
AU  - Wiese CH
AD  - Department of Anesthesiology, University Medical Center Regensburg, Regensburg
      Germany. christoph.wiese@klinik.uni-regensburg.de
FAU - Bartels, U E
AU  - Bartels UE
FAU - Ruppert, D B
AU  - Ruppert DB
FAU - Graf, B M
AU  - Graf BM
FAU - Hanekop, G G
AU  - Hanekop GG
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20101209
PL  - Italy
TA  - Minerva Anestesiol
JT  - Minerva anestesiologica
JID - 0375272
SB  - IM
MH  - Adult
MH  - Advance Directive Adherence
MH  - *Advance Directives
MH  - Emergency Medical Services/*standards
MH  - Female
MH  - Germany
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Palliative Care/standards
MH  - *Physicians
MH  - Surveys and Questionnaires
MH  - Terminal Care
EDAT- 2010/12/15 06:00
MHDA- 2011/06/29 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
AID - R02105653 [pii]
PST - ppublish
SO  - Minerva Anestesiol. 2011 Feb;77(2):172-9. Epub 2010 Dec 9.


PMID- 21149950
OWN - NLM
STAT- MEDLINE
DCOM- 20110404
LR  - 20211020
IS  - 1361-6560 (Electronic)
IS  - 0031-9155 (Linking)
VI  - 56
IP  - 1
DP  - 2011 Jan 7
TI  - Multi-frequency characterization of the speed of sound and attenuation
      coefficient for longitudinal transmission of freshly excised human skulls.
PG  - 219-50
LID - 10.1088/0031-9155/56/1/014 [doi]
AB  - For medical applications of ultrasound inside the brain, it is necessary to
      understand the relationship between the apparent density of skull bone and its
      corresponding speed of sound and attenuation coefficient. Although there have
      been previous studies exploring this phenomenon, there is still a need to extend 
      the measurements to cover more of the clinically relevant frequency range. The
      results of measurements of the longitudinal speed of sound and attenuation
      coefficient are presented for specimens of human calvaria. The study was
      performed for the frequencies of 0.27, 0.836, 1.402, 1.965 and 2.525 MHz.
      Specimens were obtained from fresh cadavers through a protocol with the Division 
      of Anatomy of the University of Toronto. The protocol was approved by the
      Research Ethics Board of Sunnybrook Health Sciences Centre. The specimens were
      mounted in polycarbonate supports that were marked for stereoscopic positioning. 
      Computer tomography (CT) scans of the skulls mounted on their supports were
      performed, and a three-dimensional skull surface was reconstructed. This surface 
      was used to guide a positioning system to ensure the normal sound incidence of an
      acoustic signal. This signal was produced by a focused device with a diameter of 
      5 cm and a focal length of 10 cm. Measurements of delay in time of flight were
      carried out using a needle hydrophone. Measurements of effective transmitted
      energy were carried out using a radiation force method with a 10 microg
      resolution scale. Preliminary functions of speed of sound and attenuation
      coefficient, both of which are related to apparent density, were established
      using a multi-layer propagation model that takes into account speed of sound,
      density and thickness of the layer. An optimization process was executed from a
      large set of random functions and the best functions were chosen for those ones
      that closest reproduced the experimental observations. The final functions were
      obtained after a second pass of the optimization process was executed, but this
      time using a finite-difference time-difference solution of the Westervelt
      equation, which is more precise than the multi-layer model but much more time
      consuming for computation. For six of seven specimens, measurements were carried 
      out on five locations on the calvaria, and for the other specimen three
      measurements were made. In total, measurements were carried out on 33 locations. 
      Results indicated the presence of dispersion effects and that these effects are
      different according to the type of bone in the skull (cortical and trabecular).
      Additionally, both the speed of sound and attenuation showed dependence on the
      skull density that varied with the frequency. Using the optimal functions and the
      information of density from the CT scans, the average values (+/-s.d.) of the
      speed of sound for cortical bone were estimated to be 2384(+/- 130), 2471(+/-
      90), 2504(+/- 120), 2327(+/- 90) and 2053(+/- 40) m s(-1) for the frequencies of 
      270, 836, 1402, 1965 and 2526 kHz, respectively. For trabecular bone, and in the 
      same order of frequency values, the speeds of sound were 2140(+/- 130), 2300(+/- 
      100), 2219(+/- 200), 2133(+/- 130) and 1937(+/- 40) m s(-1), respectively. The
      average values of the attenuation coefficient for cortical bone were 33(+/- 9),
      240(+/- 9) and 307(+/- 30) Np m(-1) for the frequencies of 270, 836, and 1402,
      respectively. For trabecular bone, and in the same order of frequency values, the
      average values of the attenuation coefficient were 34(+/- 13), 216(+/- 16) and
      375(+/- 30) Np m(-1), respectively. For frequencies of 1.965 and 2.525 MHz, no
      measurable radiation force was detected with the setup used.
FAU - Pichardo, Samuel
AU  - Pichardo S
AD  - Department of Electrical Engineering, Lakehead University and Image-guided
      Interventions, Thunder Bay Regional Research Institute, 980 Oliver Road, Thunder 
      Bay, ON, P7B 6V4, Canada. pichards@tbh.net
FAU - Sin, Vivian W
AU  - Sin VW
FAU - Hynynen, Kullervo
AU  - Hynynen K
LA  - eng
GR  - R01 EB009032/EB/NIBIB NIH HHS/United States
GR  - R01 EB009032-04/EB/NIBIB NIH HHS/United States
GR  - R01EB009032/EB/NIBIB NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20101209
PL  - England
TA  - Phys Med Biol
JT  - Physics in medicine and biology
JID - 0401220
SB  - IM
MH  - Biomechanical Phenomena
MH  - Computer Simulation
MH  - Humans
MH  - Imaging, Three-Dimensional
MH  - Models, Biological
MH  - Skull/*diagnostic imaging/*physiology
MH  - Tomography, X-Ray Computed/methods
MH  - Ultrasonics/*methods
MH  - Ultrasonography
PMC - PMC3166773
MID - NIHMS310655
EDAT- 2010/12/15 06:00
MHDA- 2011/04/05 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/04/05 06:00 [medline]
AID - S0031-9155(11)62883-7 [pii]
AID - 10.1088/0031-9155/56/1/014 [doi]
PST - ppublish
SO  - Phys Med Biol. 2011 Jan 7;56(1):219-50. doi: 10.1088/0031-9155/56/1/014. Epub
      2010 Dec 9.


PMID- 21149560
OWN - NLM
STAT- MEDLINE
DCOM- 20110421
LR  - 20101214
IS  - 1552-5724 (Electronic)
IS  - 0898-0101 (Linking)
VI  - 28
IP  - 4
DP  - 2010 Dec
TI  - Florence Nightingale's contribution to contemporary nursing ethics.
PG  - 331-2
LID - 10.1177/0898010110383281 [doi]
AB  - Florence Nightingale brought nursing from a disreputable and immoral vocation
      into the honest and ethical profession that is enjoyed today by emphasizing
      strict morals in the personal and work lives of her nursing students. In modern
      day, ethical principles guide the nursing profession and have many relevant
      connections to Nightingale's morals. Just as the high moral character of
      Nightingale's nurses helped nursing rise to a profession in her day, teaching and
      following ethical principles is crucial in furthering the nursing profession in
      our day.
FAU - Hoyt, Stephanie
AU  - Hoyt S
AD  - Brigham Young University College of Nursing, Provo, UT 84602, USA.
      stephjen06@gmail.com
LA  - eng
PT  - Biography
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - J Holist Nurs
JT  - Journal of holistic nursing : official journal of the American Holistic Nurses'
      Association
JID - 8506709
MH  - Education, Nursing/ethics/*history
MH  - England
MH  - Ethics, Nursing/*history
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Moral Development
MH  - Morals
MH  - Nurse's Role/*history
MH  - Nurse-Patient Relations/*ethics
MH  - *Virtues
PS  - Nightingale F
FPS - Nightingale, Florence
EDAT- 2010/12/15 06:00
MHDA- 2011/04/22 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/04/22 06:00 [medline]
AID - 28/4/331 [pii]
AID - 10.1177/0898010110383281 [doi]
PST - ppublish
SO  - J Holist Nurs. 2010 Dec;28(4):331-2. doi: 10.1177/0898010110383281.


PMID- 21147749
OWN - NLM
STAT- MEDLINE
DCOM- 20110118
LR  - 20181023
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 341
DP  - 2010 Dec 8
TI  - Ethics code for professional medical writers emphasises transparency and
      completeness of research reporting.
PG  - c7025
LID - 10.1136/bmj.c7025 [doi]
LID - bmj.c7025 [pii]
FAU - Mayor, Susan
AU  - Mayor S
LA  - eng
PT  - News
DEP - 20101208
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
SB  - IM
MH  - *Codes of Ethics
MH  - Publishing/*ethics
MH  - Societies/*ethics/standards
MH  - Writing/*standards
EDAT- 2010/12/15 06:00
MHDA- 2011/01/19 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/01/19 06:00 [medline]
AID - 10.1136/bmj.c7025 [doi]
PST - epublish
SO  - BMJ. 2010 Dec 8;341:c7025. doi: 10.1136/bmj.c7025.


PMID- 21146974
OWN - NLM
STAT- MEDLINE
DCOM- 20110601
LR  - 20220330
IS  - 1879-2456 (Electronic)
IS  - 0956-053X (Linking)
VI  - 31
IP  - 4
DP  - 2011 Apr
TI  - How are WEEE doing? A global review of the management of electrical and
      electronic wastes.
PG  - 714-30
LID - 10.1016/j.wasman.2010.10.023 [doi]
AB  - This paper presents and critically analyses the current waste electrical and
      electronic equipment (WEEE) management practices in various countries and
      regions. Global trends in (i) the quantities and composition of WEEE; and (ii)
      the various strategies and practices adopted by selected countries to handle,
      regulate and prevent WEEE are comprehensively examined. The findings indicate
      that for (i), the quantities of WEEE generated are high and/or on the increase.
      IT and telecommunications equipment seem to be the dominant WEEE being generated,
      at least in terms of numbers, in Africa, in the poorer regions of Asia and in
      Latin/South America. However, the paper contends that the reported figures on
      quantities of WEEE generated may be grossly underestimated. For (ii), with the
      notable exception of Europe, many countries seem to be lacking or are slow in
      initiating, drafting and adopting WEEE regulations. Handling of WEEE in
      developing countries is typified by high rate of repair and reuse within a
      largely informal recycling sector. In both developed and developing nations, the 
      landfilling of WEEE is still a concern. It has been established that stockpiling 
      of unwanted electrical and electronic products is common in both the USA and less
      developed economies. The paper also identifies and discusses four common priority
      areas for WEEE across the globe, namely: (i) resource depletion; (ii) ethical
      concerns; (iii) health and environmental issues; and (iv) WEEE takeback
      strategies. Further, the paper discusses the future perspectives on WEEE
      generation, treatment, prevention and regulation. Four key conclusions are drawn 
      from this review: global amounts of WEEE will continue unabated for some time due
      to emergence of new technologies and affordable electronics; informal recycling
      in developing nations has the potential of making a valuable contribution if
      their operations can be changed with strict safety standards as a priority; the
      pace of initiating and enacting WEEE specific legislation is very slow across the
      globe and in some cases non-existent; and globally, there is need for more
      accurate and current data on amounts and types of WEEE generated.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Ongondo, F O
AU  - Ongondo FO
AD  - School of Civil Engineering and the Environment, University of Southampton,
      Lanchester Building, University Rd., Highfield, Southampton, Hampshire SO17 1BJ, 
      UK.
FAU - Williams, I D
AU  - Williams ID
FAU - Cherrett, T J
AU  - Cherrett TJ
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20101213
PL  - United States
TA  - Waste Manag
JT  - Waste management (New York, N.Y.)
JID - 9884362
SB  - IM
MH  - Electricity
MH  - Electronic Waste/*analysis
MH  - Global Health
MH  - International Cooperation
MH  - Recycling/legislation & jurisprudence/*methods/standards
MH  - Waste Management/legislation & jurisprudence/*methods/standards
EDAT- 2010/12/15 06:00
MHDA- 2011/06/02 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/03/10 00:00 [received]
PHST- 2010/10/22 00:00 [revised]
PHST- 2010/10/29 00:00 [accepted]
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/06/02 06:00 [medline]
AID - S0956-053X(10)00565-9 [pii]
AID - 10.1016/j.wasman.2010.10.023 [doi]
PST - ppublish
SO  - Waste Manag. 2011 Apr;31(4):714-30. doi: 10.1016/j.wasman.2010.10.023. Epub 2010 
      Dec 13.


PMID- 21146634
OWN - NLM
STAT- MEDLINE
DCOM- 20110601
LR  - 20151119
IS  - 1559-2030 (Electronic)
IS  - 1551-7144 (Linking)
VI  - 32
IP  - 2
DP  - 2011 Mar
TI  - Ethics in clinical research: need for assessing comprehension of informed consent
      form?
PG  - 169-72
LID - 10.1016/j.cct.2010.12.002 [doi]
AB  - Comprehension of informed consent form has not achieved the attention it
      deserves. We made a 24-item questionnaire to assess clinical research
      participants' comprehension of informed consent form (Contemp Clin Trials
      2009;30:427-30). Due to repeated requests by clinical researchers in our country 
      and abroad, we are publishing the questionnaire in this article.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Shafiq, Nusrat
AU  - Shafiq N
AD  - Dept of Pharmacology, Postgraduate Institute of Medical Education & Research,
      Chandigarh 160012, India. Nusrat_shafiq@hotmail.com
FAU - Malhotra, Samir
AU  - Malhotra S
LA  - eng
PT  - Journal Article
DEP - 20101210
PL  - United States
TA  - Contemp Clin Trials
JT  - Contemporary clinical trials
JID - 101242342
SB  - IM
MH  - Clinical Trials as Topic/ethics
MH  - Comprehension
MH  - *Ethics, Research
MH  - Humans
MH  - Informed Consent/*ethics/psychology/standards
MH  - *Mental Competency/psychology
MH  - Surveys and Questionnaires
EDAT- 2010/12/15 06:00
MHDA- 2011/06/02 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/08/26 00:00 [received]
PHST- 2010/11/16 00:00 [revised]
PHST- 2010/12/01 00:00 [accepted]
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/06/02 06:00 [medline]
AID - S1551-7144(10)00238-7 [pii]
AID - 10.1016/j.cct.2010.12.002 [doi]
PST - ppublish
SO  - Contemp Clin Trials. 2011 Mar;32(2):169-72. doi: 10.1016/j.cct.2010.12.002. Epub 
      2010 Dec 10.


PMID- 21145538
OWN - NLM
STAT- MEDLINE
DCOM- 20110316
LR  - 20110117
IS  - 1873-7838 (Electronic)
IS  - 0010-0277 (Linking)
VI  - 118
IP  - 2
DP  - 2011 Feb
TI  - Blind ethics: Closing one's eyes polarizes moral judgments and discourages
      dishonest behavior.
PG  - 280-5
LID - 10.1016/j.cognition.2010.11.008 [doi]
AB  - Four experiments demonstrate that closing one's eyes affects ethical judgment and
      behavior because it induces people to mentally simulate events more extensively. 
      People who considered situations with their eyes closed rather than open judged
      immoral behaviors as more unethical and moral behaviors as more ethical. In
      addition, considering potential decisions with closed eyes decreased stated
      intentions to behave ethically and actual self-interested behavior. This
      relationship was mediated by the more extensive mental simulation that occurred
      with eyes closed rather than open, which, in turn, intensified emotional
      reactions to the ethical situation. We discuss the implications of these findings
      for moral psychology and ethical decision making.
CI  - Copyright (c) 2010 Elsevier B.V. All rights reserved.
FAU - Caruso, Eugene M
AU  - Caruso EM
AD  - The University of Chicago, Booth School of Business, 5807 South Woodlawn Avenue, 
      Chicago, IL 60637, USA. ecaruso@chicagobooth.edu
FAU - Gino, Francesca
AU  - Gino F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101209
PL  - Netherlands
TA  - Cognition
JT  - Cognition
JID - 0367541
SB  - IM
MH  - Decision Making/*ethics
MH  - Emotions
MH  - Humans
MH  - Imagination
MH  - Judgment
MH  - Morals
MH  - *Visual Perception
EDAT- 2010/12/15 06:00
MHDA- 2011/03/17 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/08/13 00:00 [received]
PHST- 2010/11/05 00:00 [revised]
PHST- 2010/11/09 00:00 [accepted]
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/03/17 06:00 [medline]
AID - S0010-0277(10)00267-2 [pii]
AID - 10.1016/j.cognition.2010.11.008 [doi]
PST - ppublish
SO  - Cognition. 2011 Feb;118(2):280-5. doi: 10.1016/j.cognition.2010.11.008. Epub 2010
      Dec 9.


PMID- 21145260
OWN - NLM
STAT- MEDLINE
DCOM- 20110719
LR  - 20110307
IS  - 1090-2376 (Electronic)
IS  - 1053-8100 (Linking)
VI  - 20
IP  - 1
DP  - 2011 Mar
TI  - The self as phenotype.
PG  - 109-19
LID - 10.1016/j.concog.2010.09.012 [doi]
AB  - Self-awareness is viewed here as the phenotypic expression of an interaction
      between genes and the environment. Brain and behavioral development of fetuses
      and newborn infants are a rich source of information regarding what might
      constitute minimal self-awareness. Research indicates that newborns have feeling 
      (subjective) experience. Unlike automata, they do not just sense and respond to
      proximal stimulations. In light of the explosive brain growth that takes place
      inside and outside of the womb, first signs of feeling as opposed to sensing
      experience are discussed. Feeling experience is considered as the necessary
      condition for having minimal self-awareness. Both would co-emerge in development.
      However, minimal self-awareness is rapidly supplemented with an awareness that is
      not just perceptual, but also conceptual and ethical, primarily defined in
      relation to and by others.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Rochat, Philippe
AU  - Rochat P
AD  - Department of Psychology, Emory University, 36 Eagle Row, Atlanta, GA 30322, USA.
      psypr@emory.edu
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20101208
PL  - United States
TA  - Conscious Cogn
JT  - Consciousness and cognition
JID - 9303140
SB  - IM
MH  - Brain/embryology/growth & development/*physiology
MH  - Child Development/physiology
MH  - Child, Preschool
MH  - *Ego
MH  - Emotions/physiology
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - *Phenotype
MH  - *Self Concept
EDAT- 2010/12/15 06:00
MHDA- 2011/07/20 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/09/02 00:00 [received]
PHST- 2010/09/09 00:00 [revised]
PHST- 2010/09/10 00:00 [accepted]
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/07/20 06:00 [medline]
AID - S1053-8100(10)00178-9 [pii]
AID - 10.1016/j.concog.2010.09.012 [doi]
PST - ppublish
SO  - Conscious Cogn. 2011 Mar;20(1):109-19. doi: 10.1016/j.concog.2010.09.012. Epub
      2010 Dec 8.


PMID- 21145244
OWN - NLM
STAT- MEDLINE
DCOM- 20120113
LR  - 20131121
IS  - 1873-734X (Electronic)
IS  - 1010-7940 (Linking)
VI  - 40
IP  - 1
DP  - 2011 Jul
TI  - Randomized double-blind comparison of phrenic nerve infiltration and
      suprascapular nerve block for ipsilateral shoulder pain after thoracic surgery.
PG  - 106-12
LID - 10.1016/j.ejcts.2010.10.025 [doi]
AB  - OBJECTIVE: Despite the use of thoracic epidural analgesia, a constant severe ache
      occurs in the ipsilateral shoulder of almost 75% of patients after thoracotomy.
      The aim of this prospective-randomized study was to investigate the effect of
      phrenic nerve infiltration (PNI) compared with suprascapular nerve block (SNB) on
      ipsilateral shoulder pain after thoracic surgery. METHODS: After Local Research
      Ethics Committee approval, written informed consent was obtained from 90 adult
      patients undergoing thoracotomy for pulmonary resection. Patients were excluded
      if they had preexisting shoulder pain, were unable to understand the visual
      analog scale (VAS) scoring system or due to failure of epidural analgesia. The
      phrenic group (PNI) received 10 ml of 2% lidocaine infiltrated into the
      periphrenic fat pad, 1-2 cm close to the diaphragm, just before chest closure.
      The suprascapular group (SNB) received 10 ml of 0.5% plain bupivacaine injected
      into the suprascapular fossa once the surgery was finished. A blinded observer to
      the study group assessed the patient's shoulder and thoracotomy pain, using the
      VAS score and a five-point observer verbal rating score (OVRS), at 0.5, 1, 2, 3, 
      4, 5, 6, 12, 48, and 72 h after surgery and at discharge. The time and dose of
      any administered analgesic medication were recorded. RESULTS: Finally, 74
      patients were included (37 per group). Sixteen patients were excluded (unable to 
      understand scoring system, failure of the epidural technique, and lost data).
      There were no significant differences in age, gender, body mass index,
      type/duration of operation, and pain scores at rest, between the two groups.
      Shoulder pain intensity was significantly lower in the PNI group compared with
      the SNB group (median value of VAS area under the curve for the PNI group: 8.1
      (0-70.9)cm vs 114.3 (43.8-193.8)cm for the SNB group; p < 0.001). There were no
      significant differences between the two groups according to postoperative
      thoracotomy pain. CONCLUSIONS: Phrenic nerve block with 2% lidocaine should be
      performed in all patients undergoing a major thoracic surgery procedure. These
      results strongly support the hypothesis that irritation of the pericardium and/or
      mediastinal-diaphragmatic pleural surfaces results in pain that is referred to
      the shoulder via the phrenic nerve.
CI  - Copyright (c) 2010 European Association for Cardio-Thoracic Surgery. Published by
      Elsevier B.V. All rights reserved.
FAU - Martinez-Barenys, Carlos
AU  - Martinez-Barenys C
AD  - Thoracic Surgery Department, University Hospital Germans Trias i Pujol, Badalona,
      Barcelona, Spain. cmartinezb.germanstrias@gencat.cat
FAU - Busquets, Jordi
AU  - Busquets J
FAU - de Castro, Pedro E Lopez
AU  - de Castro PE
FAU - Garcia-Guasch, Roser
AU  - Garcia-Guasch R
FAU - Perez, Javier
AU  - Perez J
FAU - Fernandez, Esther
AU  - Fernandez E
FAU - Mesa, Miguel A
AU  - Mesa MA
FAU - Astudillo, Julio
AU  - Astudillo J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20101208
PL  - Germany
TA  - Eur J Cardiothorac Surg
JT  - European journal of cardio-thoracic surgery : official journal of the European
      Association for Cardio-thoracic Surgery
JID - 8804069
RN  - 0 (Anesthetics, Local)
RN  - 98PI200987 (Lidocaine)
RN  - Y8335394RO (Bupivacaine)
SB  - IM
CIN - Eur J Cardiothorac Surg. 2012 Mar;41(3):716; author reply 716-7. PMID: 22345201
MH  - Aged
MH  - Anesthetics, Local/*administration & dosage
MH  - Bupivacaine/administration & dosage
MH  - Double-Blind Method
MH  - Drug Administration Schedule
MH  - Female
MH  - Humans
MH  - Lidocaine/administration & dosage
MH  - Male
MH  - Middle Aged
MH  - Nerve Block/*methods
MH  - Pain Measurement/methods
MH  - Pain, Postoperative/diagnosis/*prevention & control
MH  - Phrenic Nerve
MH  - Pneumonectomy/adverse effects/methods
MH  - Prospective Studies
MH  - Shoulder Pain/diagnosis/etiology/*prevention & control
MH  - Thoracotomy/*adverse effects
EDAT- 2010/12/15 06:00
MHDA- 2012/01/14 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/05/25 00:00 [received]
PHST- 2010/09/26 00:00 [revised]
PHST- 2010/10/11 00:00 [accepted]
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2012/01/14 06:00 [medline]
AID - S1010-7940(10)00905-X [pii]
AID - 10.1016/j.ejcts.2010.10.025 [doi]
PST - ppublish
SO  - Eur J Cardiothorac Surg. 2011 Jul;40(1):106-12. doi: 10.1016/j.ejcts.2010.10.025.
      Epub 2010 Dec 8.


PMID- 21144607
OWN - NLM
STAT- MEDLINE
DCOM- 20110706
LR  - 20220331
IS  - 1879-0887 (Electronic)
IS  - 0167-8140 (Linking)
VI  - 98
IP  - 2
DP  - 2011 Feb
TI  - Set-up errors in radiotherapy for oesophageal cancers--is electronic portal
      imaging or conebeam more accurate?
PG  - 249-54
LID - 10.1016/j.radonc.2010.11.002 [doi]
AB  - PURPOSE: To compare kV computed tomography (CBCT) with electronic portal imaging 
      (EPI) and evaluate set-up variations in the anterior-posterior (AP), right-left
      (LR) and cranio-caudal (CC) directions and rotational variations: pitch, roll,
      and yaw, for oesophageal cancer patients treated with radical radiotherapy.
      METHODS AND MATERIALS: Twenty patients with locally advanced oesophageal cancer
      treated with chemoradiation were consented for this prospective ethics approved
      protocol. Patients were positioned using skin marks/tattoos, kV-CBCT scans (XVI) 
      and EPI's were performed prior to treatment and registered to the planning CT
      scans and digitally reconstructed radiographs, respectively. XVI data was used to
      adjust patient setups before treatment delivery. A total of 122 EPI pairs and 207
      CBCT scans were analysed. The systematic and random errors were calculated.
      RESULTS: The systematic and random errors (mm) for XVI were 1.3, 1.7, 1.4 and
      2.6, 3.9, 2.0 in RL, CC and AP direction, respectively, with EPI of similar
      magnitude. There was no correlation between the 2 modalities of imaging as 31.7% 
      of all image pairs were discordant >3 mm and 12.5% >5 mm. XVI identified
      rotations >3 degrees in 44 images. CONCLUSIONS: EPI results in different position
      correction for verification of radiotherapy in oesophageal malignancies when
      compared with CBCT. CBCT verification offers adequate 3D volumetric image quality
      to improve the accuracy of treatment delivery for oesophageal malignancies in
      radiotherapy and should be used for image guidance.
CI  - Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Hawkins, Maria A
AU  - Hawkins MA
AD  - Department of Radiotherapy, Royal Marsden NHS Foundation Trust, Surrey, UK.
      maria.hawkins@rmh.nhs.uk
FAU - Aitken, Alexandra
AU  - Aitken A
FAU - Hansen, Vibeke N
AU  - Hansen VN
FAU - McNair, Helen A
AU  - McNair HA
FAU - Tait, Diana M
AU  - Tait DM
LA  - eng
GR  - 10588/CRUK_/Cancer Research UK/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101206
PL  - Ireland
TA  - Radiother Oncol
JT  - Radiotherapy and oncology : journal of the European Society for Therapeutic
      Radiology and Oncology
JID - 8407192
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cone-Beam Computed Tomography/*methods
MH  - Esophageal Neoplasms/diagnostic imaging/pathology/*radiotherapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
EDAT- 2010/12/15 06:00
MHDA- 2011/07/08 06:00
CRDT- 2010/12/15 06:00
PHST- 2009/12/14 00:00 [received]
PHST- 2010/11/11 00:00 [revised]
PHST- 2010/11/14 00:00 [accepted]
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/07/08 06:00 [medline]
AID - S0167-8140(10)00688-2 [pii]
AID - 10.1016/j.radonc.2010.11.002 [doi]
PST - ppublish
SO  - Radiother Oncol. 2011 Feb;98(2):249-54. doi: 10.1016/j.radonc.2010.11.002. Epub
      2010 Dec 6.


PMID- 21144472
OWN - NLM
STAT- MEDLINE
DCOM- 20110503
LR  - 20101214
IS  - 0078-6608 (Print)
IS  - 0078-6608 (Linking)
VI  - 81
IP  - 4
DP  - 2010 Dec
TI  - [Therapeutic patient education for children and adolescents: some dentofacial
      orthopedic reflections].
PG  - 315-21
LID - 10.1051/orthodfr/2010028 [doi]
AB  - Non-compliance and, even more, abandonment of treatment raise many questions.
      From a medical and economic point of view, these occurrences affect the
      efficiency of the proposed therapy. These failures therefore invite us to
      question the nature and purpose of health care providers' mission. Adherence of
      the patient to medical advice is a key factor to the success of the therapy.
      Therefore, how can we modify the patient's behaviour, particularly when dealing
      with teenage patients? How can we adopt and make our own a therapeutic strategy
      encouraging cooperation of patients? Patient education, recently integrated into 
      the French public health code (Code de la sante publique), brings new elements to
      answer these questions. The purpose of the present work is to question the
      concept of patient education, notably with regards to medical ethics. What can
      patient education bring to medical practices that face non compliance or
      deficiency of adherence to treatment recommendations? What new perspectives does 
      patient education bring, notably regarding medical practices?
CI  - (c) EDP Sciences, SFODF, 2010.
FAU - Mano, Marie-Charlotte
AU  - Mano MC
AD  - Departement d'ODF, Centre de soins dentaires, 2 Place Pasteur, 35000 Rennes,
      France. charlottemano@hotmail.fr
FAU - Begue-Simon, Anne-Marie
AU  - Begue-Simon AM
FAU - Hamel, Olivier
AU  - Hamel O
FAU - Sorel, Olivier
AU  - Sorel O
FAU - Herve, Christian
AU  - Herve C
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Education therapeutique de l'enfant et de l'adolescent: reflexions ethiques en
      orthopedie dento-faciale.
DEP - 20101210
PL  - France
TA  - Orthod Fr
JT  - L' Orthodontie francaise
JID - 0200547
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Dentist-Patient Relations/*ethics
MH  - Humans
MH  - Orthodontics, Corrective/*ethics
MH  - *Patient Compliance
MH  - Patient Education as Topic/*ethics
MH  - Personal Autonomy
MH  - Quality of Life
MH  - Treatment Refusal
EDAT- 2010/12/15 06:00
MHDA- 2011/05/04 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/05/04 06:00 [medline]
AID - 10.1051/orthodfr/2010028 [doi]
AID - or1028 [pii]
PST - ppublish
SO  - Orthod Fr. 2010 Dec;81(4):315-21. doi: 10.1051/orthodfr/2010028. Epub 2010 Dec
      10.


PMID- 21144468
OWN - NLM
STAT- MEDLINE
DCOM- 20110503
LR  - 20101214
IS  - 0078-6608 (Print)
IS  - 0078-6608 (Linking)
VI  - 81
IP  - 4
DP  - 2010 Dec
TI  - [The skill hand and the face: optic and haptic surgery].
PG  - 269-78
LID - 10.1051/orthodfr/2010031 [doi]
AB  - For the surgeon of the face, there is an obvious ambiguity in the relationship
      between the hand and the face, because the first is etymologically linked to the 
      grounds of the surgeon trade and which face does it mean? The face of the man,
      who, hidden behind his surgical mask, tries to repair the disfigured face or the 
      face of the patient he cares about in the way to give him a new face and a new
      identity through even more complex surgeries? There is actually an analogy with
      the painter and his model, the sculptor and his hand which shapes, the pianist
      player and the works he performs, the writer and the memories which inspire his
      novel. The authors would like here to point out this facing of feelings but also 
      theirs tangles in something which could be named the tactilisation of the seeing 
      and visualisation of the touch; sort of requested community between optic and
      haptic. Applied to the facial transplantation this disturbing strangeness, the
      schizophrenic questioning dived ourselves in an abyssal vertigo from which only
      the ethics as aesthetics of the inside could save us.
CI  - (c) EDP Sciences, SFODF, 2010.
FAU - Devauchelle, Bernard
AU  - Devauchelle B
AD  - Universite Picardie Jules Verne, CHRU, Service de Chirurgie Maxillo-Faciale et
      Stomatologie, place Victor Pauchet, 80054 Amiens Cedex, France. cmf@chu-amiens.fr
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - La main savante et le visage: optique et haptique chirurgicale. Conference
      inaugurale presentee lors des Journees de l'Orthodontie, Paris 2010.
DEP - 20101210
PL  - France
TA  - Orthod Fr
JT  - L' Orthodontie francaise
JID - 0200547
SB  - IM
MH  - *Facial Transplantation
MH  - Female
MH  - Hand/physiology
MH  - Humans
MH  - Motor Skills
MH  - Self Concept
MH  - Touch Perception
MH  - Visual Perception
EDAT- 2010/12/15 06:00
MHDA- 2011/05/04 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/05/04 06:00 [medline]
AID - 10.1051/orthodfr/2010031 [doi]
AID - or1031 [pii]
PST - ppublish
SO  - Orthod Fr. 2010 Dec;81(4):269-78. doi: 10.1051/orthodfr/2010031. Epub 2010 Dec
      10.


PMID- 21144324
OWN - NLM
STAT- MEDLINE
DCOM- 20110331
LR  - 20171116
IS  - 1646-0758 (Electronic)
IS  - 0870-399X (Linking)
VI  - 23
IP  - 5
DP  - 2010 Sep-Oct
TI  - [Vaccination during pregnancy].
PG  - 837-40
AB  - INTRODUCTION: Vaccination of pregnant women causes concerns both for themselves
      and for their healthcare providers. The main concern is the possibility of
      transmission of the virus/bacteria to the fetus in development. Due to obvious
      underlying ethical questions, clinical trials in this area are scarce and of
      difficult accomplishment. OBJECTIVES: The aim of this paper is to formulate
      proper guidance for vaccine Administration in pregnant women, particularly on
      cases of inadvertent administration, through the review of current evidence on
      live-attenuated vaccine administration in pregnant women. METHODOLOGY: Medline,
      Bandolier, The Cochrane Library and National Guideline Clearinghouse were
      searched using the following keywords (MeSH terms): vaccination AND pregnancy.
      The search was limited to articles published from January 2003 to December 2008. 
      After exclusion of articles not concordant with the objectives of the review, 12 
      articles were selected (four review articles, two guidelines, one dissertation,
      the remaining were original articles), as well as the portuguese guidelines from 
      Direccao Geral de Saude (DGS) in what respects to vaccine administration.
      CONCLUSIONS: The contraindication of live-attenuated vaccine administration in
      pregnant women is based on the hypothetical/theoretical risk of potential
      negative effects for the developing fetus. Physicians should consider vaccinating
      pregnant women on the basis of the risks of vaccination versus the benefits of
      protection in each particular situation. Women should be told to avoid getting
      pregnant in the 28 days after liveattenuated vaccination. However, the
      inadvertent vaccination is not considered an indication for termination of the
      pregnancy.
FAU - Pimentel, Marta Arnaut
AU  - Pimentel MA
AD  - Medicina Geral e Familiar, Unidade de Saude de S. Joao do Estoril, Cascais.
LA  - por
PT  - Journal Article
PT  - Review
TT  - Vacinacao durante a gravidez.
DEP - 20101022
PL  - Portugal
TA  - Acta Med Port
JT  - Acta medica portuguesa
JID - 7906803
SB  - IM
MH  - Contraindications
MH  - Female
MH  - Humans
MH  - Pregnancy
MH  - *Vaccination
EDAT- 2010/12/15 06:00
MHDA- 2011/04/01 06:00
CRDT- 2010/12/15 06:00
PHST- 2009/03/02 00:00 [received]
PHST- 2009/12/18 00:00 [accepted]
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/04/01 06:00 [medline]
PST - ppublish
SO  - Acta Med Port. 2010 Sep-Oct;23(5):837-40. Epub 2010 Oct 22.


PMID- 21143987
OWN - NLM
STAT- MEDLINE
DCOM- 20120113
LR  - 20211020
IS  - 1472-6963 (Electronic)
IS  - 1472-6963 (Linking)
VI  - 10
DP  - 2010 Dec 10
TI  - Exploring the potential for foreign-trained dentists to address workforce
      shortages and improve access to dental care for vulnerable populations in the
      United States: a case study from Washington State.
PG  - 336
LID - 10.1186/1472-6963-10-336 [doi]
AB  - BACKGROUND: To address dental workforce shortages in underserved areas in the
      United States, some States have enacted legislation to make it easier for foreign
      dental school graduates to become licensed dentists. However, the extent to which
      foreign dental school graduates will solve the problem of dental workforce
      shortages is poorly understood. Furthermore, the potential impact that
      foreign-trained dentists have on improving access to dental care for vulnerable
      patients living in dental Health Professional Shortage Areas (HPSAs) and those
      enrolled in public insurance programs, such as Medicaid, is unknown. The
      objective of this paper is to provide a preliminary understanding of the practice
      behaviors of foreign-trained dentists. The authors used Washington State as a
      case study to identify the potential impact foreign dental school graduates have 
      on improving access to dental care for vulnerable populations. The following
      hypotheses were tested: a) among all newly licensed dentists, foreign-trained
      dentists are more likely to participate in the Medicaid program than U.S.-trained
      dentists; and b) among newly licensed dentists who participated in the Medicaid
      program, foreign-trained dentists are more likely to practice in dental HPSAs
      than U.S.-trained dentists. METHODS: The authors used dental license and Medicaid
      license data to compare the proportions of newly licensed, foreign- and
      U.S.-trained dentists who participated in the Medicaid program and the
      proportions that practiced in a dental HPSA. RESULTS: Using bivariate analyses,
      the authors found that a significantly lower proportion of foreign-trained
      dentists participated in the Medicaid program than U.S.-trained dentists (12.9%
      and 22.8%, respectively; P = 0.011). Among newly licensed dentists who
      participated in the Medicaid program, there was no significant difference in the 
      proportions of foreign- and U.S.-trained dentists who practiced in a dental HPSA 
      (P = 0.683). CONCLUSIONS: Legislation that makes it easier for foreign-trained
      dentists to obtain licensure is unlikely to address dental workforce shortages or
      improve access to dental care for vulnerable populations in the United States.
      Licensing foreign dental school graduates in the United States also has ethical
      implications for the dental workforces in other countries.
FAU - Bazargan, Naseem
AU  - Bazargan N
AD  - University of Washington School of Dentistry, Department of Dental Public Health 
      Sciences, 1959 NE Pacific Street, Box 357475, Seattle, WA 98195, USA.
FAU - Chi, Donald L
AU  - Chi DL
FAU - Milgrom, Peter
AU  - Milgrom P
LA  - eng
GR  - K08 DE020856/DE/NIDCR NIH HHS/United States
GR  - K08-DE020856-01/DE/NIDCR NIH HHS/United States
GR  - U54DE019346/DE/NIDCR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20101210
PL  - England
TA  - BMC Health Serv Res
JT  - BMC health services research
JID - 101088677
SB  - IM
MH  - Adult
MH  - Dentists/economics/*supply & distribution
MH  - Female
MH  - Foreign Professional Personnel/*statistics & numerical data
MH  - Health Education, Dental/standards
MH  - Health Services Accessibility/*standards
MH  - Humans
MH  - Licensure, Dental/classification/statistics & numerical data
MH  - Male
MH  - Medicaid/economics/organization & administration
MH  - Medically Underserved Area
MH  - Organizational Case Studies
MH  - Professional Practice Location/statistics & numerical data
MH  - Quality Assurance, Health Care/*methods
MH  - Reimbursement Mechanisms
MH  - Rural Health Services/statistics & numerical data
MH  - United States
MH  - Urban Health Services/statistics & numerical data
MH  - Vulnerable Populations
MH  - Washington
PMC - PMC3017531
EDAT- 2010/12/15 06:00
MHDA- 2012/01/14 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/09/10 00:00 [received]
PHST- 2010/12/10 00:00 [accepted]
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2012/01/14 06:00 [medline]
AID - 1472-6963-10-336 [pii]
AID - 10.1186/1472-6963-10-336 [doi]
PST - epublish
SO  - BMC Health Serv Res. 2010 Dec 10;10:336. doi: 10.1186/1472-6963-10-336.


PMID- 21143931
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1752-1505 (Electronic)
IS  - 1752-1505 (Linking)
VI  - 4
IP  - 1
DP  - 2010 Dec 9
TI  - Identifying priority healthcare trainings in frozen conflict situations: The case
      of Nagorno Karabagh.
PG  - 21
LID - 10.1186/1752-1505-4-21 [doi]
AB  - INTRODUCTION: Health care in post-war situations, where the system's human and
      fixed capital are depleted, is challenging. The addition of a frozen conflict
      situation, where international recognition of boundaries and authorities are
      lacking, introduces further complexities. CASE DESCRIPTION: Nagorno Karabagh (NK)
      is an ethnically Armenian territory locked within post-Soviet Azerbaijan and one 
      such frozen conflict situation. This article highlights the use of evidence-based
      practice and community engagement to determine priority areas for health care
      training in NK. Drawing on the precepts of APEXPH (Assessment Protocol for
      Excellence in Public Health) and MAPP (Mobilizing for Action through Planning and
      Partnerships), this first-of-its-kind assessment in NK relied on in-depth
      interviews and focus group discussions supplemented with expert assessments and
      field observations. Training options were evaluated against a series of ethical
      and pragmatic principles. DISCUSSION AND EVALUATION: A unique factor among the
      ethical and pragmatic considerations when prioritizing among alternatives was
      NK's ambiguous political status and consequent sponsor constraints. Training
      priorities differed across the region and by type of provider, but consensus
      prioritization emerged for first aid, clinical Integrated Management of Childhood
      Illnesses, and Adult Disease Management. These priorities were then incorporated 
      into the training programs funded by the sponsor. CONCLUSIONS: Programming
      responsive to both the evidence-base and stakeholder priorities is always
      desirable and provides a foundation for long-term planning and response. In
      frozen conflict, low resource settings, such an approach is critical to balancing
      the community's immediate humanitarian needs with sponsor concerns and
      constraints.
FAU - Thompson, Michael E
AU  - Thompson ME
AD  - Assistant Professor Coordinator, MSPH Program Department of Public Health
      Sciences, University of North Carolina at CharlotteCharlotte, NC, USA.
      methomp1@uncc.edu.
FAU - Dorian, Alina H
AU  - Dorian AH
FAU - Harutyunyan, Tsovinar L
AU  - Harutyunyan TL
LA  - eng
PT  - Journal Article
DEP - 20101209
PL  - England
TA  - Confl Health
JT  - Conflict and health
JID - 101286573
PMC - PMC3022565
EDAT- 2010/12/15 06:00
MHDA- 2010/12/15 06:01
CRDT- 2010/12/15 06:00
PHST- 2010/10/12 00:00 [received]
PHST- 2010/12/09 00:00 [accepted]
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2010/12/15 06:01 [medline]
AID - 1752-1505-4-21 [pii]
AID - 10.1186/1752-1505-4-21 [doi]
PST - epublish
SO  - Confl Health. 2010 Dec 9;4(1):21. doi: 10.1186/1752-1505-4-21.


PMID- 21143864
OWN - NLM
STAT- MEDLINE
DCOM- 20110307
LR  - 20220316
IS  - 1471-2377 (Electronic)
IS  - 1471-2377 (Linking)
VI  - 10
DP  - 2010 Dec 8
TI  - Program of rehabilitative exercise and education to avert vascular events after
      non-disabling stroke or transient ischemic attack (PREVENT Trial): a
      multi-centred, randomised controlled trial.
PG  - 122
LID - 10.1186/1471-2377-10-122 [doi]
AB  - BACKGROUND: Despite lack of outward signs, most individuals after non-disabling
      stroke (NDS) and transient ischemic attack (TIA) have significant cardiovascular 
      and cerebrovascular disease and are at high risk of a major stroke,
      hospitalization for other vascular events, or death. Most have multiple
      modifiable risk factors (e.g., hypertension, physical inactivity,
      hyperlipidaemia, diabetes, tobacco consumption, psychological stress). In
      addition, accelerated rates of depression, cognitive decline, and poor quality of
      sleep have been reported following TIA, which correlate with poor functional
      outcomes and reduced quality of life. Thus, NSD and TIA are important warning
      signs that should not be overlooked. The challenge is not unlike that facing
      other 'silent' conditions - to identify a model of care that is effective in
      changing people's current behaviors in order to avert further morbidity.
      METHODS/DESIGN: A single blind, randomized controlled trial will be conducted at 
      two sites to compare the effectiveness of a program of rehabilitative exercise
      and education versus usual care in modifying vascular risk factors in adults
      after NDS/TIA. 250 adults within 90 days of being diagnosed with NDS/TIA will be 
      randomly allocated to a 12-week program of exercise and education (PREVENT) or to
      an outpatient clinic assessment and discussion of secondary prevention
      recommendations with return clinic visits as indicated (USUAL CARE). Primary
      outcome measures will include blood pressure, waist circumference, 12-hour
      fasting lipid profile, and 12-hour fasting glucose/hemoglobin A1c. Secondary
      measures will include exercise capacity, walking endurance, physical activity,
      cognitive function, depression, goal attainment and health-related quality of
      life. Outcome assessment will be conducted at baseline, post-intervention, and 6-
      and 12-month follow-ups. Direct health care costs incurred over one year by
      PREVENT versus USUAL CARE participants will also be compared. Ethical approval
      for the trial has been obtained from the relevant Human Research Ethics Boards.
      DISCUSSION: Whether timely delivery of an adapted cardiac rehabilitation model is
      effective in attaining and maintaining vascular risk reduction targets in adults 
      after NDS/TIA is not yet known. We anticipate that the findings of this trial
      will make a meaningful contribution to the knowledge base regarding secondary
      stroke prevention.
FAU - MacKay-Lyons, Marilyn
AU  - MacKay-Lyons M
AD  - School of Physiotherapy, Dalhousie University, Halifax, Nova Scotia, Canada.
      m.mackay-lyons@dal.ca
FAU - Gubitz, Gordon
AU  - Gubitz G
FAU - Giacomantonio, Nicholas
AU  - Giacomantonio N
FAU - Wightman, Howard
AU  - Wightman H
FAU - Marsters, David
AU  - Marsters D
FAU - Thompson, Kara
AU  - Thompson K
FAU - Blanchard, Chris
AU  - Blanchard C
FAU - Eskes, Gail
AU  - Eskes G
FAU - Thornton, Marianne
AU  - Thornton M
LA  - eng
SI  - ClinicalTrials.gov/NCT00885456
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20101208
PL  - England
TA  - BMC Neurol
JT  - BMC neurology
JID - 100968555
SB  - IM
MH  - Clinical Protocols
MH  - Female
MH  - Humans
MH  - Ischemic Attack, Transient/*prevention & control/*rehabilitation
MH  - Male
MH  - Patient Selection
MH  - *Risk Reduction Behavior
MH  - Secondary Prevention/*methods
MH  - Single-Blind Method
MH  - Stroke/*prevention & control
MH  - *Stroke Rehabilitation
PMC - PMC3004878
EDAT- 2010/12/15 06:00
MHDA- 2011/03/08 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/10/24 00:00 [received]
PHST- 2010/12/08 00:00 [accepted]
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/03/08 06:00 [medline]
AID - 1471-2377-10-122 [pii]
AID - 10.1186/1471-2377-10-122 [doi]
PST - epublish
SO  - BMC Neurol. 2010 Dec 8;10:122. doi: 10.1186/1471-2377-10-122.


PMID- 21142996
OWN - NLM
STAT- MEDLINE
DCOM- 20110325
LR  - 20181201
IS  - 2152-2723 (Electronic)
IS  - 2152-2715 (Linking)
VI  - 13
IP  - 6
DP  - 2010 Dec
TI  - Analysis of college students' online life-styles and their psychological profiles
      in South Korea.
PG  - 701-4
LID - 10.1089/cyber.2009.0443 [doi]
AB  - This study examines the relationships between the online life-styles of South
      Korean students as Internet users and Internet use, their tendency toward
      Internet addiction, and the level of cyber ethics. A sample of 324 students, aged
      between 18 and 23 years, from a medium-sized university in South Korea was asked 
      to complete a survey. They were categorized into three groups depending on their 
      online life-styles: a Social group (SG), an Individual group (IG), and a Loner
      group (LG). In the following analyses, no group difference was found in hours of 
      Internet use on either weekdays or weekends, but the SG reported higher
      engagement in interaction-oriented activities (e.g. blogging, games, and instant 
      messenger services) than the LG. As for tendency toward Internet addiction, all
      three groups belonged to the first phase of the "at-risk" classification in
      Korea. Interestingly, the IG characteristics of sensation seeking and
      independence reported the lowest scores in cyber ethics, while the LG
      characteristics of apathetic attitude toward the Internet reported the highest
      scores in cyber ethics. This preliminary study showed that Internet users impose 
      different meanings and values on their Internet experiences, which contribute to 
      their use of Internet services, their tendency toward Internet addiction, and
      their level of cyber ethics.
FAU - Lee, Sujin
AU  - Lee S
AD  - Department of Education, Kookmin University, Seoul, Korea. sjlee@kookmin.ac.kr
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100511
PL  - United States
TA  - Cyberpsychol Behav Soc Netw
JT  - Cyberpsychology, behavior and social networking
JID - 101528721
SB  - IM
MH  - Adolescent
MH  - Analysis of Variance
MH  - Behavior, Addictive/*psychology
MH  - Data Collection
MH  - Female
MH  - Humans
MH  - Internet/*statistics & numerical data
MH  - Interpersonal Relations
MH  - *Life Style
MH  - Male
MH  - *Personality
MH  - Republic of Korea
MH  - Students/*psychology/statistics & numerical data
MH  - Universities
MH  - Young Adult
EDAT- 2010/12/15 06:00
MHDA- 2011/03/26 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/03/26 06:00 [medline]
AID - 10.1089/cyber.2009.0443 [doi]
PST - ppublish
SO  - Cyberpsychol Behav Soc Netw. 2010 Dec;13(6):701-4. doi: 10.1089/cyber.2009.0443. 
      Epub 2010 May 11.


PMID- 21142995
OWN - NLM
STAT- MEDLINE
DCOM- 20110325
LR  - 20220321
IS  - 2152-2723 (Electronic)
IS  - 2152-2715 (Linking)
VI  - 13
IP  - 6
DP  - 2010 Dec
TI  - Participant dropout as a function of survey length in internet-mediated
      university studies: implications for study design and voluntary participation in 
      psychological research.
PG  - 697-700
LID - 10.1089/cyber.2009.0445 [doi]
AB  - Internet-mediated research has offered substantial advantages over traditional
      laboratory-based research in terms of efficiently and affordably allowing for the
      recruitment of large samples of participants for psychology studies. Core
      technical, ethical, and methodological issues have been addressed in recent
      years, but the important issue of participant dropout has received surprisingly
      little attention. Specifically, web-based psychology studies often involve
      undergraduates completing lengthy and time-consuming batteries of online
      personality questionnaires, but no known published studies to date have closely
      examined the natural course of participant dropout during attempted completion of
      these studies. The present investigation examined participant dropout among 1,963
      undergraduates completing one of six web-based survey studies relatively
      representative of those conducted in university settings. Results indicated that 
      10% of participants could be expected to drop out of these studies nearly
      instantaneously, with an additional 2% dropping out per 100 survey items included
      in the study. For individual project investigators, these findings hold
      ramifications for study design considerations, such as conducting a priori power 
      analyses. The present results also have broader ethical implications for
      understanding and improving voluntary participation in research involving human
      subjects. Nonetheless, the generalizability of these conclusions may be limited
      to studies involving similar design or survey content.
FAU - Hoerger, Michael
AU  - Hoerger M
AD  - Department of Psychiatry, University of Rochester Medical Center, Rochester, New 
      York 14642, USA. michael_hoerger@urmc.rochester.edu
LA  - eng
GR  - T32 MH018911/MH/NIMH NIH HHS/United States
GR  - T32 MH018911-23/MH/NIMH NIH HHS/United States
PT  - Journal Article
DEP - 20100511
PL  - United States
TA  - Cyberpsychol Behav Soc Netw
JT  - Cyberpsychology, behavior and social networking
JID - 101528721
SB  - IM
MH  - Adolescent
MH  - *Data Collection
MH  - Female
MH  - Humans
MH  - *Internet
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - *Patient Dropouts
MH  - *Research Design
MH  - Surveys and Questionnaires
MH  - Universities
MH  - Young Adult
PMC - PMC4367493
EDAT- 2010/12/15 06:00
MHDA- 2011/03/26 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/03/26 06:00 [medline]
AID - 10.1089/cyber.2009.0445 [doi]
PST - ppublish
SO  - Cyberpsychol Behav Soc Netw. 2010 Dec;13(6):697-700. doi:
      10.1089/cyber.2009.0445. Epub 2010 May 11.


PMID- 21142618
OWN - NLM
STAT- MEDLINE
DCOM- 20110512
LR  - 20220129
IS  - 1473-4877 (Electronic)
IS  - 0300-7995 (Linking)
VI  - 27
IP  - 2
DP  - 2011 Feb
TI  - Recommendations for an update of 2003 European regulatory requirements for
      registration of drugs to be used in the treatment of RA.
PG  - 315-25
LID - 10.1185/03007995.2010.542135 [doi]
AB  - Since 2003, the European Medicines Agency (EMA) document, 'Points to consider on 
      clinical investigation of medicinal products other than NSAIDs (nonsteroidal
      anti-inflammatory drugs) for the treatment of rheumatoid arthritis' has provided 
      guidance for the clinical development of both biologic and non-biologic
      disease-modifying antirheumatic drugs (DMARDs). In the last few years, several
      new products have been developed or are in development for the treatment of RA,
      which offer significant efficacy with regard to disease control, including
      prevention of structural damage and disability. Concurrently, novel insights have
      been gained with respect to the assessment of disease activity, joint damage and 
      disability. New treatment strategies have been established which relate to early 
      therapy, tight control and rapid switching of medication. Accordingly, several
      new EULAR/ACR recommendations have been or are being developed. Several important
      additions and changes are needed in the 2003 guidance to incorporate the current 
      scientific knowledge into clinical trial design for the development of future
      products. Under the auspices of the Group for the Respect of Ethics and
      Excellence in Science (GREES), a group of experts in the field of RA and clinical
      trial design met to provide a consensus recommendation for an update to the 2003 
      EMA guidance document.
FAU - Smolen, Josef S
AU  - Smolen JS
AD  - Hietzing Hospital, Vienna, Austria.
FAU - Boers, Maarten
AU  - Boers M
FAU - Abadie, Eric C
AU  - Abadie EC
FAU - Breedveld, Ferdinand C
AU  - Breedveld FC
FAU - Emery, Paul
AU  - Emery P
FAU - Bardin, Thomas
AU  - Bardin T
FAU - Goel, Niti
AU  - Goel N
FAU - Ethgen, Dominique J
AU  - Ethgen DJ
FAU - Avouac, Bernard P
AU  - Avouac BP
FAU - Dere, Willard H
AU  - Dere WH
FAU - Durez, Patrick
AU  - Durez P
FAU - Matucci-Cerinic, Marco
AU  - Matucci-Cerinic M
FAU - Flamion, Bruno
AU  - Flamion B
FAU - Laslop, Andrea
AU  - Laslop A
FAU - Lekkerkerker, Frits J
AU  - Lekkerkerker FJ
FAU - Miossec, Pierre
AU  - Miossec P
FAU - Mitlak, Bruce H
AU  - Mitlak BH
FAU - Ormarsdottir, Sif
AU  - Ormarsdottir S
FAU - Paolozzi, Laurence
AU  - Paolozzi L
FAU - Rao, Ravi
AU  - Rao R
FAU - Reiter, Susan
AU  - Reiter S
FAU - Tsouderos, Yannis
AU  - Tsouderos Y
FAU - Reginster, Jean-Yves
AU  - Reginster JY
CN  - Group for Respect of Ethics and Excellence in Science (GREES)
LA  - eng
GR  - 18475/ARC_/Arthritis Research UK/United Kingdom
GR  - 18475/VAC_/Versus Arthritis/United Kingdom
PT  - Journal Article
PT  - Practice Guideline
PT  - Research Support, Non-U.S. Gov't
DEP - 20101209
PL  - England
TA  - Curr Med Res Opin
JT  - Current medical research and opinion
JID - 0351014
RN  - 0 (Antirheumatic Agents)
RN  - 0 (Placebos)
RN  - YL5FZ2Y5U1 (Methotrexate)
SB  - IM
MH  - Antirheumatic Agents/*therapeutic use
MH  - Clinical Trials, Phase III as Topic
MH  - Drug Approval/*legislation & jurisprudence
MH  - Drug and Narcotic Control/legislation & jurisprudence/*trends
MH  - Europe
MH  - *Health Planning Guidelines
MH  - Humans
MH  - Methotrexate/administration & dosage/therapeutic use
MH  - Placebos
MH  - Practice Guidelines as Topic
MH  - Rheumatic Fever/*drug therapy
MH  - Time Factors
EDAT- 2010/12/15 06:00
MHDA- 2011/05/13 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/05/13 06:00 [medline]
AID - 10.1185/03007995.2010.542135 [doi]
PST - ppublish
SO  - Curr Med Res Opin. 2011 Feb;27(2):315-25. doi: 10.1185/03007995.2010.542135. Epub
      2010 Dec 9.


PMID- 21141204
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20101210
IS  - 0020-6539 (Print)
IS  - 0020-6539 (Linking)
VI  - 60
IP  - 5
DP  - 2010 Oct
TI  - The chasm between knowing and choosing the ethical course of action. A survey of 
      dental students in the Netherlands.
PG  - 321-8
AB  - The dental profession is gradually becoming more aware of the importance of
      practitioner competence in dental ethics and law. Indicative of that awareness is
      the explicit attention paid by ever more dental school curricula to these
      disciplines through courses and other dedicated learning activities. Concurrently
      there is also increasing professional concern about reports of illegal and
      unethical behaviour by dental students and practitioners. This paper discusses
      the results of a survey among first and fifth year students enrolled in the three
      Dutch dental schools, examining their ethical and legal knowledge and
      perceptions. Students were presented with five ethical and five legal case
      vignettes and asked which of three courses of actions is correct, as well as
      which of those courses they would undertake themselves. The study shows that the 
      knowledge level of students in the area of health law increases between the first
      and fifth year but their knowledge of ethics decreases. Even more remarkable is
      the finding that large numbers of students are not consistent, that is, the way
      they plan to behave does not coincide with what they say is the morally correct
      way to behave.
FAU - Brands, Wolter G
AU  - Brands WG
AD  - Department of Dentistry, Radboud University Nijmegen Medical Centre, the
      Netherlands. w.brands@dent.umcn.nl
FAU - Bronkhorst, Ewald M
AU  - Bronkhorst EM
FAU - Welie, Jos V M
AU  - Welie JV
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int Dent J
JT  - International dental journal
JID - 0374714
SB  - IM
MH  - Attitude of Health Personnel
MH  - *Choice Behavior
MH  - Clinical Competence
MH  - Codes of Ethics
MH  - Dentist-Patient Relations/ethics
MH  - Dentists/ethics
MH  - Ethics, Dental/*education
MH  - Humans
MH  - Legislation, Dental
MH  - Morals
MH  - Netherlands
MH  - Practice Guidelines as Topic
MH  - *Students, Dental
EDAT- 2010/12/15 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
PST - ppublish
SO  - Int Dent J. 2010 Oct;60(5):321-8.


PMID- 21140876
OWN - NLM
STAT- MEDLINE
DCOM- 20101223
LR  - 20191111
IS  - 1078-4535 (Print)
IS  - 1078-4535 (Linking)
VI  - 16
IP  - 4
DP  - 2010
TI  - Creating a healthy work environment for nursing faculty.
PG  - 193-7
AB  - Nursing administrators and faculty have a professional and ethical responsibility
      to develop and maintain a caring and healthy work environment for nursing
      faculty. To recruit and retain quality nursing faculty in the current nursing
      faculty shortage, a healthy work environment is essential. This article focuses
      on nursing administrators' and nursing faculty members' role in promoting a
      healthy academic work environment. Strategies to develop and sustain this
      environment are discussed.
FAU - Kuehn, Mary Beth
AU  - Kuehn MB
AD  - St. Olaf College, Northfield, Minnesota, USA. kuehn@stolaf.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Creat Nurs
JT  - Creative nursing
JID - 9505022
MH  - Attitude of Health Personnel
MH  - Cooperative Behavior
MH  - Creativity
MH  - Empathy
MH  - Faculty, Nursing/*organization & administration
MH  - Humans
MH  - Interprofessional Relations
MH  - Job Satisfaction
MH  - *Nurse Administrators/organization & administration/psychology
MH  - Nurse's Role/psychology
MH  - *Occupational Health
MH  - Organizational Culture
MH  - Personnel Selection
MH  - Personnel Turnover
MH  - Schools, Nursing/*organization & administration
MH  - Social Environment
MH  - Social Support
MH  - *Workplace/organization & administration/psychology
EDAT- 2010/12/15 06:00
MHDA- 2010/12/25 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2010/12/25 06:00 [medline]
AID - 10.1891/1078-4535.16.4.193 [doi]
PST - ppublish
SO  - Creat Nurs. 2010;16(4):193-7. doi: 10.1891/1078-4535.16.4.193.


PMID- 21140851
OWN - NLM
STAT- MEDLINE
DCOM- 20110120
LR  - 20101209
IS  - 0882-1577 (Print)
IS  - 0882-1577 (Linking)
VI  - 91
IP  - 6
DP  - 2010 Nov-Dec
TI  - Ethics of right relation: all are responsible for all.
PG  - 64-6
FAU - Father Thomas Nairn
AU  - Father Thomas Nairn
AD  - Catholic Health Association, St. Louis, USA. tnairn@chausa.org
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Health Prog
JT  - Health progress (Saint Louis, Mo.)
JID - 8500263
MH  - Catholicism
MH  - Health Care Reform
MH  - *Religion and Medicine
MH  - *Right to Die
MH  - *Social Justice
MH  - United States
EDAT- 2010/12/15 06:00
MHDA- 2011/01/21 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/01/21 06:00 [medline]
PST - ppublish
SO  - Health Prog. 2010 Nov-Dec;91(6):64-6.


PMID- 21140579
OWN - NLM
STAT- MEDLINE
DCOM- 20101214
LR  - 20101208
IS  - 0023-7205 (Print)
IS  - 0023-7205 (Linking)
VI  - 107
IP  - 40
DP  - 2010 Oct 6-12
TI  - [Ten myths about medical ethics to put an end to].
PG  - 2419-21
FAU - Engstrom, Ingemar
AU  - Engstrom I
AD  - Psykiatriskt forskningscentrum, Orebro.
FAU - Lynoe, Niels
AU  - Lynoe N
LA  - swe
PT  - Journal Article
TT  - Tio myter att avliva om medicinsk etik.
PL  - Sweden
TA  - Lakartidningen
JT  - Lakartidningen
JID - 0027707
SB  - IM
MH  - Attitude of Health Personnel
MH  - *Ethics, Medical/education
MH  - Humans
MH  - Professional Competence
MH  - Students, Medical/psychology
EDAT- 2010/12/15 06:00
MHDA- 2010/12/16 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2010/12/16 06:00 [medline]
PST - ppublish
SO  - Lakartidningen. 2010 Oct 6-12;107(40):2419-21.


PMID- 21140524
OWN - NLM
STAT- MEDLINE
DCOM- 20120601
LR  - 20220321
IS  - 1539-1612 (Electronic)
IS  - 1539-1604 (Linking)
VI  - 10
IP  - 4
DP  - 2011 Jul-Aug
TI  - A guide to the design and analysis of small clinical studies.
PG  - 363-8
LID - 10.1002/pst.477 [doi]
AB  - Clinical studies, which have a small number of patients, are conducted by
      pharmaceutical companies and research institutions. Examples of constraints that 
      lead to a small clinical study include a single investigative site with a highly 
      specialized expertise or equipment, rare diseases, and limited time and budget.
      We consider the following topics, which we believe will be helpful for the
      investigator and statistician working together on the design and analysis of
      small clinical studies: definitions of various types of small studies
      (exploratory, pilot, proof of concept); bias and ways to mitigate the bias;
      commonly used study designs for randomized and nonrandomized studies, and some
      less commonly used designs; potential ethical issues associated with small
      underpowered clinical studies; sample size for small studies; statistical
      analysis methods for different types of variables and multiplicity issues. We
      conclude the paper with recommendations made by an Institute of Medicine
      committee, which was asked to assess the current methodologies and appropriate
      situations for conducting small clinical studies.
CI  - Copyright (c) 2010 John Wiley & Sons, Ltd.
FAU - Kianifard, Farid
AU  - Kianifard F
AD  - Biometrics, US Medical and Drug Regulatory Affairs, Novartis Pharmaceuticals
      Corporation, East Hanover, NJ 07936, USA. farid.kianifard@novartis.com
FAU - Islam, M Zahur
AU  - Islam MZ
LA  - eng
PT  - Journal Article
DEP - 20101208
PL  - England
TA  - Pharm Stat
JT  - Pharmaceutical statistics
JID - 101201192
SB  - IM
MH  - Bias
MH  - Clinical Trials as Topic/ethics/*methods
MH  - Data Interpretation, Statistical
MH  - Drug Industry/methods
MH  - Humans
MH  - Models, Statistical
MH  - National Academies of Science, Engineering, and Medicine, U.S., Health and
      Medicine Division
MH  - Randomized Controlled Trials as Topic/ethics/*methods
MH  - *Research Design
MH  - Sample Size
MH  - United States
EDAT- 2010/12/09 06:00
MHDA- 2012/06/02 06:00
CRDT- 2010/12/09 06:00
PHST- 2010/12/09 06:00 [entrez]
PHST- 2010/12/09 06:00 [pubmed]
PHST- 2012/06/02 06:00 [medline]
AID - 10.1002/pst.477 [doi]
PST - ppublish
SO  - Pharm Stat. 2011 Jul-Aug;10(4):363-8. doi: 10.1002/pst.477. Epub 2010 Dec 8.


PMID- 21140341
OWN - NLM
STAT- MEDLINE
DCOM- 20110317
LR  - 20101208
IS  - 0047-262X (Print)
VI  - 57
IP  - 6
DP  - 2010 Dec
TI  - [Calamitous moments: rethinking the ethics of post disaster psychological
      reconstruction programs].
PG  - 24-30
AB  - This article points out firstly that disaster and traumatic events resulting from
      calamitous moments must be the focus of dedicated long term research and of
      ontological caring in practice. Ethical issues related to the post disaster
      psychological reconstruction program represent an important agenda. Therefore, in
      the execution of serial programs and nursing care, it should not be taken for
      granted that sufferers are destined to be pathological clients. Rather, each
      sufferer should be attended to in a humanistic manner. In other words, the
      elimination of symptoms cannot be our only focus. Secondly, the author discusses 
      the ethical dimensions of post-disaster psychological intervention within a "Five
      T" framework (namely, tears, time, talk, transformation, and trauma). The author 
      then explores the meaning of posttraumatic psychological growth, which is
      relevant to the resilience that coexists with suffering. Finally, it is important
      to practice ontological care from the context of being "within" the relationship,
      rather from a rigid cognition regarding program efficiencies. 'Being' provides
      much greater depth than 'doing'.
FAU - Lin, Yaw-Sheng
AU  - Lin YS
AD  - Department of Counseling and Clinical Psychology, National Dong Hwa University,
      Hualien County, Taiwan, ROC. yslin@mail.ndhu.edu.tw
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China (Republic : 1949- )
TA  - Hu Li Za Zhi
JT  - Hu li za zhi The journal of nursing
JID - 0073267
SB  - IM
MH  - *Disasters
MH  - Humans
MH  - Psychotherapy/*ethics
MH  - Stress Disorders, Post-Traumatic/*psychology
EDAT- 2010/12/09 06:00
MHDA- 2011/03/18 06:00
CRDT- 2010/12/09 06:00
PHST- 2010/12/09 06:00 [entrez]
PHST- 2010/12/09 06:00 [pubmed]
PHST- 2011/03/18 06:00 [medline]
PST - ppublish
SO  - Hu Li Za Zhi. 2010 Dec;57(6):24-30.


PMID- 21140340
OWN - NLM
STAT- MEDLINE
DCOM- 20110317
LR  - 20101208
IS  - 0047-262X (Print)
VI  - 57
IP  - 6
DP  - 2010 Dec
TI  - [Biomedicalization: considering ethical issues in providing maternal serum
      screening].
PG  - 18-23
AB  - The purpose of this article was to explore nursing care within the framework of
      emerging biomedicine (biomedicalization) trends using the example of maternal
      serum screening. Five key interactive processes linking biomedicine and caring
      were addressed, including social impact, value of life, status of pregnant women,
      professional relationships, and caring attitudes on the ethic of reverence for
      life.
FAU - Chiang, Hsien-Hsien
AU  - Chiang HH
AD  - Department of Nursing, National Yang-Ming University, Taipei, Taiwan, ROC.
      hhchiang@ym.edu.tw
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China (Republic : 1949- )
TA  - Hu Li Za Zhi
JT  - Hu li za zhi The journal of nursing
JID - 0073267
SB  - IM
MH  - Down Syndrome/*diagnosis
MH  - *Ethics, Nursing
MH  - Female
MH  - Genetic Techniques
MH  - Humans
MH  - Pregnancy/*blood
MH  - Prenatal Diagnosis/*ethics
EDAT- 2010/12/09 06:00
MHDA- 2011/03/18 06:00
CRDT- 2010/12/09 06:00
PHST- 2010/12/09 06:00 [entrez]
PHST- 2010/12/09 06:00 [pubmed]
PHST- 2011/03/18 06:00 [medline]
PST - ppublish
SO  - Hu Li Za Zhi. 2010 Dec;57(6):18-23.


PMID- 21140339
OWN - NLM
STAT- MEDLINE
DCOM- 20110317
LR  - 20101208
IS  - 0047-262X (Print)
VI  - 57
IP  - 6
DP  - 2010 Dec
TI  - [Anti-stigmatization and ethical perspectives on mental illness and genetic
      technologies].
PG  - 11-7
AB  - People with mental illness suffer from their disorder as well as from social
      stigma. This paper explores the bio-psycho-social reasons that underlie human
      stigma and proposes potential anti-stigmatization strategies. Furthermore, this
      paper presents a multi-component, multi-level intervention genetic psychiatry
      protocol addressing stigma prevention. Significant levels of social stigma still 
      pervade Taiwanese culture, and a potential crisis of genetic psychiatry exists in
      cases where mental illness is identified. Promoting humanistic, ethical, and
      caring attitudes and enhancing genetic nursing education at both the community
      level and amongst health professional are central to ensuring the rights and
      quality of life of the mentally ill in Taiwan society.
FAU - Sheu, Shuh-Jen
AU  - Sheu SJ
AD  - School of Nursing, National Yang-Ming University, Taipei, Taiwan, ROC.
      sjsheu@ym.edu.tw
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China (Republic : 1949- )
TA  - Hu Li Za Zhi
JT  - Hu li za zhi The journal of nursing
JID - 0073267
SB  - IM
MH  - *Ethics
MH  - *Genetic Techniques
MH  - Humans
MH  - Mental Disorders/genetics/*psychology
MH  - Quality of Life
MH  - *Social Stigma
MH  - Stereotyping
MH  - Taiwan
EDAT- 2010/12/09 06:00
MHDA- 2011/03/18 06:00
CRDT- 2010/12/09 06:00
PHST- 2010/12/09 06:00 [entrez]
PHST- 2010/12/09 06:00 [pubmed]
PHST- 2011/03/18 06:00 [medline]
PST - ppublish
SO  - Hu Li Za Zhi. 2010 Dec;57(6):11-7.


PMID- 21140102
OWN - NLM
STAT- MEDLINE
DCOM- 20110510
LR  - 20191210
IS  - 1518-8787 (Electronic)
IS  - 0034-8910 (Linking)
VI  - 45
IP  - 1
DP  - 2011 Feb
TI  - Validation of a proposal for evaluating hospital infection control programs.
PG  - 121-8
LID - S0034-89102010005000052 [pii]
AB  - OBJECTIVE: To validate the construct and discriminant properties of a hospital
      infection prevention and control program. METHODS: The program consisted of four 
      indicators: technical-operational structure; operational prevention and control
      guidelines; epidemiological surveillance system; and prevention and control
      activities. These indicators, with previously validated content, were applied to 
      50 healthcare institutions in the city of Sao Paulo, Southeastern Brazil, in
      2009. Descriptive statistics were used to characterize the hospitals and
      indicator scores, and Cronbach's alpha coefficient was used to evaluate the
      internal consistency. The discriminant validity was analyzed by comparing
      indicator scores between groups of hospitals: with versus without quality
      certification. The construct validity analysis was based on exploratory factor
      analysis with a tetrachoric correlation matrix. RESULTS: The indicators for the
      technical-operational structure and epidemiological surveillance presented almost
      100% conformity in the whole sample. The indicators for the operational
      prevention and control guidelines and the prevention and control activities
      presented internal consistency ranging from 0.67 to 0.80. The discriminant
      validity of these indicators indicated higher and statistically significant mean 
      conformity scores among the group of institutions with healthcare certification
      or accreditation processes. In the construct validation, two dimensions were
      identified for the operational prevention and control guidelines: recommendations
      for preventing hospital infection and recommendations for standardizing
      prophylaxis procedures, with good correlation between the analysis units that
      formed the guidelines. The same was found for the prevention and control
      activities: interfaces with treatment units and support units were identified.
      CONCLUSIONS: Validation of the measurement properties of the hospital infection
      prevention and control program indicators made it possible to develop a tool for 
      evaluating these programs in an ethical and scientific manner in order to obtain 
      a quality diagnosis in this field.
FAU - Silva, Cristiane Pavanello Rodrigues
AU  - Silva CP
AD  - Divisao de Prevencao de Infeccao, 3M do Brasil, Sumare, SP, Brasil.
      cris_pr_silva@hotmail.com
FAU - Lacerda, Rubia Aparecida
AU  - Lacerda RA
LA  - eng
LA  - por
PT  - Journal Article
PT  - Validation Study
DEP - 20101210
PL  - Brazil
TA  - Rev Saude Publica
JT  - Revista de saude publica
JID - 0135043
SB  - IM
MH  - Brazil
MH  - Cross Infection/*prevention & control
MH  - Humans
MH  - Infection Control/*standards
MH  - Models, Statistical
MH  - Program Evaluation/methods/*standards
EDAT- 2010/12/09 06:00
MHDA- 2011/05/11 06:00
CRDT- 2010/12/09 06:00
PHST- 2010/01/19 00:00 [received]
PHST- 2010/08/02 00:00 [accepted]
PHST- 2010/12/09 06:00 [entrez]
PHST- 2010/12/09 06:00 [pubmed]
PHST- 2011/05/11 06:00 [medline]
AID - S0034-89102010005000052 [pii]
AID - 10.1590/s0034-89102010005000052 [doi]
PST - ppublish
SO  - Rev Saude Publica. 2011 Feb;45(1):121-8. doi: 10.1590/s0034-89102010005000052.
      Epub 2010 Dec 10.


PMID- 21139875
OWN - NLM
STAT- MEDLINE
DCOM- 20110323
LR  - 20211020
IS  - 1660-4601 (Electronic)
IS  - 1660-4601 (Linking)
VI  - 7
IP  - 11
DP  - 2010 Nov
TI  - The role of cumulative risk assessment in decisions about environmental justice.
PG  - 4037-49
LID - 10.3390/ijerph7114037 [doi]
AB  - There is strong presumptive evidence that people living in poverty and certain
      racial and ethnic groups bear a disproportionate burden of environmental health
      risk. Many have argued that conducting formal assessments of the health risk
      experienced by affected communities is both unnecessary and
      counterproductive-that instead of analyzing the situation our efforts should be
      devoted to fixing obvious problems and rectifying observable wrongs. We contend
      that formal assessment of cumulative health risks from combined effects of
      chemical and nonchemical stressors is a valuable tool to aid decision makers in
      choosing risk management options that are effective, efficient, and equitable. If
      used properly, cumulative risk assessment need not impair decision makers'
      discretion, nor should it be used as an excuse for doing nothing in the face of
      evident harm. Good policy decisions require more than good intentions; they
      necessitate analysis of risk-related information along with careful consideration
      of economic issues, ethical and moral principles, legal precedents, political
      realities, cultural beliefs, societal values, and bureaucratic impediments.
      Cumulative risk assessment can provide a systematic and impartial means for
      informing policy decisions about environmental justice.
FAU - Sexton, Ken
AU  - Sexton K
AD  - Department of Epidemiology, Human Genetics, and Environmental Sciences,
      University of Texas School of Public Health, Brownsville Regional Campus, 80 Fort
      Brown, Brownsville, TX 78520, USA. ken.sexton@uth.tmc.edu
FAU - Linder, Stephen H
AU  - Linder SH
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20101118
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
SB  - IM
MH  - *Environmental Health
MH  - *Risk Assessment
PMC - PMC2996223
OTO - NOTNLM
OT  - *cumulative risk assessment
OT  - *environmental justice
OT  - *health disparities
OT  - *risk assessment
OT  - *susceptible groups
OT  - *vulnerable populations
EDAT- 2010/12/09 06:00
MHDA- 2011/03/24 06:00
CRDT- 2010/12/09 06:00
PHST- 2010/10/15 00:00 [received]
PHST- 2010/10/29 00:00 [revised]
PHST- 2010/11/17 00:00 [accepted]
PHST- 2010/12/09 06:00 [entrez]
PHST- 2010/12/09 06:00 [pubmed]
PHST- 2011/03/24 06:00 [medline]
AID - 10.3390/ijerph7114037 [doi]
AID - ijerph7114037 [pii]
PST - ppublish
SO  - Int J Environ Res Public Health. 2010 Nov;7(11):4037-49. doi:
      10.3390/ijerph7114037. Epub 2010 Nov 18.


PMID- 21139819
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1052-1372 (Print)
IS  - 1052-1372 (Linking)
VI  - 35
IP  - 11
DP  - 2010 Nov
TI  - Personalized medicine: part 2: ethical, legal, and regulatory issues.
PG  - 624-42
FAU - Vogenberg, F Randy
AU  - Vogenberg FR
FAU - Barash, Carol Isaacson
AU  - Barash CI
FAU - Pursel, Michael
AU  - Pursel M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - P T
JT  - P & T : a peer-reviewed journal for formulary management
JID - 9015516
PMC - PMC2993070
OTO - NOTNLM
OT  - GINA
OT  - HIPAA Privacy Rule
OT  - HITECH
OT  - Protected Health Information
OT  - ethical, legal, and regulatory
OT  - health plans and coverage
EDAT- 2010/12/09 06:00
MHDA- 2010/12/09 06:01
CRDT- 2010/12/09 06:00
PHST- 2010/12/09 06:00 [entrez]
PHST- 2010/12/09 06:00 [pubmed]
PHST- 2010/12/09 06:01 [medline]
PST - ppublish
SO  - P T. 2010 Nov;35(11):624-42.


PMID- 21139159
OWN - NLM
STAT- MEDLINE
DCOM- 20110318
LR  - 20101208
IS  - 1554-3528 (Electronic)
IS  - 1554-351X (Linking)
VI  - 42
IP  - 4
DP  - 2010 Nov
TI  - The variable-criteria sequential stopping rule: generality to unequal sample
      sizes, unequal variances, or to large ANOVAs.
PG  - 918-29
LID - 10.3758/BRM.42.4.918 [doi]
AB  - The variable-criteria sequential stopping rule (SSR) is a method for conducting
      planned experiments in stages after the addition of new subjects until the
      experiment is stopped because the p value is less than or equal to a lower
      criterion and the null hypothesis has been rejected, the p value is above an
      upper criterion, or a maximum sample size has been reached. Alpha is controlled
      at the expected level. The table of stopping criteria has been validated for a t 
      test or ANOVA with four groups. New simulations in this article demonstrate that 
      the SSR can be used with unequal sample sizes or heterogeneous variances in a t
      test. As with the usual t test, the use of a separate-variance term instead of a 
      pooled-variance term prevents an inflation of alpha with heterogeneous variances.
      Simulations validate the original table of criteria for up to 20 groups without a
      drift of alpha. When used with a multigroup ANOVA, a planned contrast can be
      substituted for the global F as the focus for the stopping rule. The SSR is
      recommended when significance tests are appropriate and when the null hypothesis 
      can be tested in stages. Because of its efficiency, the SSR should be used
      instead of the usual approach to the t test or ANOVA when subjects are expensive,
      rare, or limited by ethical considerations such as pain or distress.
FAU - Fitts, Douglas A
AU  - Fitts DA
AD  - Office of Animal Welfare and IACUC, University of Washington, Seattle, Washington
      98195, USA. dfitts@u.washington.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Behav Res Methods
JT  - Behavior research methods
JID - 101244316
SB  - IM
MH  - *Analysis of Variance
MH  - Computer Simulation
MH  - *Research Design
MH  - *Sample Size
EDAT- 2010/12/09 06:00
MHDA- 2011/03/19 06:00
CRDT- 2010/12/09 06:00
PHST- 2010/12/09 06:00 [entrez]
PHST- 2010/12/09 06:00 [pubmed]
PHST- 2011/03/19 06:00 [medline]
AID - 42/4/918 [pii]
AID - 10.3758/BRM.42.4.918 [doi]
PST - ppublish
SO  - Behav Res Methods. 2010 Nov;42(4):918-29. doi: 10.3758/BRM.42.4.918.


PMID- 21138831
OWN - NLM
STAT- MEDLINE
DCOM- 20110201
LR  - 20101208
IS  - 1545-1097 (Print)
IS  - 1545-1097 (Linking)
VI  - 9
IP  - 6
DP  - 2010 Nov-Dec
TI  - What do people living with HIV/AIDS expect from their physicians? Professional
      expertise and the doctor-patient relationship.
PG  - 341-5
LID - 10.1177/1545109710370486 [doi]
AB  - This qualitative study identifies the types of professional expertise that
      physicians are seen to possess in clinical encounters from the perspective of
      people living with HIV/AIDS (PLWHA). Respondents looked to their physicians for
      expert knowledge in 3 key areas: medical/clinical; legal/statutory; and
      ethical/moral. Physicians were seen to be authorities in each of these areas and 
      their judgments, though not always agreed with, were taken seriously and
      influenced the health care decisions made by PLWHA. The authority that comes with
      professional expertise in each of the areas identified was experienced both
      positively and negatively by PLWHA. Understanding the expectations of patients in
      the medical encounter can assist physicians in providing optimal care in the
      management of HIV/AIDS.
FAU - Guenter, Dale
AU  - Guenter D
AD  - Department of Family Medicine, McMaster University, Hamilton, Ontario, Canada.
FAU - Gillett, James
AU  - Gillett J
FAU - Cain, Roy
AU  - Cain R
FAU - Pawluch, Dorothy
AU  - Pawluch D
FAU - Travers, Robb
AU  - Travers R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Int Assoc Physicians AIDS Care (Chic)
JT  - Journal of the International Association of Physicians in AIDS Care (Chicago,
      Ill. : 2002)
JID - 101185740
SB  - IM
MH  - Adult
MH  - Clinical Competence
MH  - Disease Management
MH  - Female
MH  - HIV Infections/*therapy
MH  - Humans
MH  - Insurance, Disability/legislation & jurisprudence
MH  - Male
MH  - Middle Aged
MH  - Morals
MH  - Ontario
MH  - Patient Rights
MH  - *Patient Satisfaction
MH  - *Physician-Patient Relations
MH  - *Quality of Health Care
EDAT- 2010/12/09 06:00
MHDA- 2011/02/02 06:00
CRDT- 2010/12/09 06:00
PHST- 2010/12/09 06:00 [entrez]
PHST- 2010/12/09 06:00 [pubmed]
PHST- 2011/02/02 06:00 [medline]
AID - 9/6/341 [pii]
AID - 10.1177/1545109710370486 [doi]
PST - ppublish
SO  - J Int Assoc Physicians AIDS Care (Chic). 2010 Nov-Dec;9(6):341-5. doi:
      10.1177/1545109710370486.


PMID- 21138697
OWN - NLM
STAT- MEDLINE
DCOM- 20110302
LR  - 20151119
IS  - 1448-7527 (Print)
IS  - 1448-7527 (Linking)
VI  - 16
IP  - 4
DP  - 2010
TI  - Children and young people in out-of-home care: are GPs ready and willing to
      provide comprehensive health assessments for this vulnerable group?
PG  - 296-303
LID - 10.1071/PY10019 [doi]
AB  - Children living in out-of-home care because of abuse or neglect are among the
      most vulnerable in Australia. In 2005 the Royal Australasian College of
      Physicians highlighted the need for increased attention to the health of such
      children and recommended regular health assessment. This qualitative study
      explored the views of a purposive sample of 20 GPs about what would influence GP 
      willingness and readiness to undertake comprehensive health assessments for
      children entering out-of-home care. Ethical concerns, training, professional
      development needs, medico-legal issues, workforce and financial pressures and
      communication problems with the child protection sector were among key factors
      identified. Professional values about continuity of health care for children
      emerged as a new issue with important policy implications. This is the first
      in-depth study in Australia of GP perspectives about systematic health
      assessments for children in child protection and sheds new light on the low GP
      uptake of such assessments for at-risk population groups.
FAU - Webster, Susan M
AU  - Webster SM
AD  - General Practice and Primary Health Care Academic Centre, Melbourne Medical
      School, University of Melbourne, 200 Berkeley Street, Carlton, Vic. 3053,
      Australia. s.webster@pgrad.unimelb.edu.au
FAU - Temple-Smith, Meredith
AU  - Temple-Smith M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Aust J Prim Health
JT  - Australian journal of primary health
JID - 101123037
SB  - IM
MH  - Adolescent
MH  - *Attitude of Health Personnel
MH  - Child
MH  - *Child Abuse
MH  - *Foster Home Care
MH  - *General Practice
MH  - *Health Services Accessibility
MH  - Humans
MH  - Interinstitutional Relations
MH  - Narration
MH  - *Practice Patterns, Physicians'
MH  - Referral and Consultation
MH  - Victoria
EDAT- 2010/12/09 06:00
MHDA- 2011/03/03 06:00
CRDT- 2010/12/09 06:00
PHST- 2010/05/26 00:00 [received]
PHST- 2010/09/27 00:00 [accepted]
PHST- 2010/12/09 06:00 [entrez]
PHST- 2010/12/09 06:00 [pubmed]
PHST- 2011/03/03 06:00 [medline]
AID - PY10019 [pii]
AID - 10.1071/PY10019 [doi]
PST - ppublish
SO  - Aust J Prim Health. 2010;16(4):296-303. doi: 10.1071/PY10019.


PMID- 21138411
OWN - NLM
STAT- MEDLINE
DCOM- 20110414
LR  - 20101208
IS  - 1088-6281 (Print)
IS  - 1088-6281 (Linking)
VI  - 25
IP  - 4
DP  - 2010
TI  - The economic value added (EVA) resulting from medical care of functional
      amblyopia, strabismus, (pathologies of binocular vision) and asthma.
PG  - 206-16
AB  - INTRODUCTION: Value analysis in health care calculates the economic value added
      (EVA) that results from improvements in health and health care. Our purpose was
      to develop an EVA model and to apply the model to typical and hypothetical
      (instantaneous and perfect) cures for amblyopia, surgical strabismus and asthma, 
      as another, but non-ophthalmological disease standard for comparison, in the
      United States. METHODS: The model is based on changes in utility and longevity,
      the associated incremental costs, and an estimate of the value of life.
      Univariate sensitivity analyses were performed to arrive at a plausible range of 
      outcomes. RESULTS: For the United States, the EVA for current practice amblyopia 
      care is 12.9B dollars (billion) per year, corresponding to a return on investment
      (ROI) of 10.4% per yr. With substantial increases in investment aimed at maximal 
      improvement ("perfect cure"), the EVA is 32.7B per yr, with ROI of 5.3% per yr.
      The EVA for typical surgical strabismus care is 10.3B per yr. A perfect cure may 
      yield EVA of 9.6B per yr. The EVA for asthma is 1317B per yr (ROI 20.4% per yr..,
      while a perfect cure may yield EVA of 110 B per yr. Sensitivity analysis
      demonstrated the relatively large effects of incidence, utility, and longevity,
      while incremental costs have a relatively minor effect on the EVA. CONCLUSION:
      The economic value added by improvements in patient-centered outcomes is very
      large. Failing to make the necessary investments in research, prevention,
      detection, prompt treatment and rehabilitation of these diseases, at virtually
      any conceivable cost, appears economically, medically, morally and ethically
      deficient and consequently wasteful at very least economically for our society.
FAU - Beauchamp, Cynthia L
AU  - Beauchamp CL
AD  - Department of Ophthalmology, University of Texas Southwestern Medical Center,
      Dallas, TX, USA.
FAU - Felius, Joost
AU  - Felius J
FAU - Beauchamp, George R
AU  - Beauchamp GR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Binocul Vis Strabismus Q
JT  - Binocular vision & strabismus quarterly
JID - 9607281
SB  - IM
MH  - Amblyopia/*economics
MH  - Asthma/*economics
MH  - Delivery of Health Care/*economics
MH  - Humans
MH  - Longevity
MH  - Models, Economic
MH  - Quality of Life
MH  - Strabismus/*economics
MH  - United States
MH  - *Value of Life
MH  - *Vision, Binocular
EDAT- 2010/12/09 06:00
MHDA- 2011/04/16 06:00
CRDT- 2010/12/09 06:00
PHST- 2010/12/09 06:00 [entrez]
PHST- 2010/12/09 06:00 [pubmed]
PHST- 2011/04/16 06:00 [medline]
PST - ppublish
SO  - Binocul Vis Strabismus Q. 2010;25(4):206-16.


PMID- 21138083
OWN - NLM
STAT- MEDLINE
DCOM- 20101223
LR  - 20220311
IS  - 1351-5578 (Print)
IS  - 1351-5578 (Linking)
VI  - 18
IP  - 1
DP  - 2010
TI  - Issues and considerations when researching sensitive issues with men: examples
      from a study of men and sexual health.
PG  - 26-34
AB  - This article highlights some ethical considerations and practicalities that arose
      when conducting research with men in relation to decision making and seeking help
      for a sexually transmitted infection (STI). The aim of the study was to explore, 
      using a grounded theory approach, the processes involved in making the decision
      to seek help. The main issues that arose were in relation to seeking permission
      and gaining approval, obtaining informed consent and susceptibility to harm. The 
      interview itself and the concept of the researcher as a tool of data collection
      also gave rise to ethical issues. These issues have implications for the conduct 
      of sensitive research with men and highlight the need for more overt reporting of
      the ethical issues and practical considerations that arise when planning and
      conducting research.
FAU - Walls, Paula
AU  - Walls P
AD  - School of Nursing, University of Ulster, County Londonderry, UK.
FAU - Parahoo, Kader
AU  - Parahoo K
FAU - Fleming, Paul
AU  - Fleming P
FAU - McCaughan, Eilis
AU  - McCaughan E
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurse Res
JT  - Nurse researcher
JID - 9435953
CIN - Nurse Res. 2010;18(1):4-7. PMID: 21138080
MH  - Confidentiality/ethics
MH  - Data Collection/ethics
MH  - Humans
MH  - Informed Consent/ethics
MH  - Interviews as Topic
MH  - Male
MH  - Men/*psychology
MH  - Northern Ireland
MH  - Nursing Methodology Research/*ethics
MH  - Patient Acceptance of Health Care/*psychology
MH  - *Qualitative Research
MH  - Research Design
MH  - Researcher-Subject Relations/ethics/psychology
MH  - Self Disclosure
MH  - Sexually Transmitted Diseases/prevention & control/*psychology
MH  - Shame
EDAT- 2010/12/09 06:00
MHDA- 2010/12/25 06:00
CRDT- 2010/12/09 06:00
PHST- 2010/12/09 06:00 [entrez]
PHST- 2010/12/09 06:00 [pubmed]
PHST- 2010/12/25 06:00 [medline]
AID - 10.7748/nr2010.10.18.1.26.c8045 [doi]
PST - ppublish
SO  - Nurse Res. 2010;18(1):26-34. doi: 10.7748/nr2010.10.18.1.26.c8045.


PMID- 21138082
OWN - NLM
STAT- MEDLINE
DCOM- 20101223
LR  - 20220408
IS  - 1351-5578 (Print)
IS  - 1351-5578 (Linking)
VI  - 18
IP  - 1
DP  - 2010
TI  - Ethical challenges in qualitative research: examples from practice.
PG  - 15-25
AB  - This article examines the many ethical challenges that are specific to
      qualitative research. These challenges concern the issues of informed consent
      procedures, the researcher-participant relationship, risk-benefit ratio,
      confidentiality and the dual role of the nurse-researcher. Each challenge will be
      examined and practical examples of how it was dealt with, using examples from a
      multiple case study, will be described.
FAU - Houghton, Catherine E
AU  - Houghton CE
AD  - School of Nursing and Midwifery Studies, National University of Ireland, Galway.
FAU - Casey, Dympna
AU  - Casey D
FAU - Shaw, David
AU  - Shaw D
FAU - Murphy, Kathy
AU  - Murphy K
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurse Res
JT  - Nurse researcher
JID - 9435953
CIN - Nurse Res. 2010;18(1):4-7. PMID: 21138080
MH  - Clinical Protocols
MH  - Confidentiality/ethics
MH  - Ethics, Research
MH  - Humans
MH  - Informed Consent/ethics
MH  - Nurse's Role
MH  - Nursing Methodology Research/*ethics
MH  - Patient Advocacy/ethics
MH  - Principle-Based Ethics
MH  - *Qualitative Research
MH  - Research Personnel/ethics
MH  - Researcher-Subject Relations/ethics
MH  - Risk Assessment/ethics
EDAT- 2010/12/09 06:00
MHDA- 2010/12/25 06:00
CRDT- 2010/12/09 06:00
PHST- 2010/12/09 06:00 [entrez]
PHST- 2010/12/09 06:00 [pubmed]
PHST- 2010/12/25 06:00 [medline]
AID - 10.7748/nr2010.10.18.1.15.c8044 [doi]
PST - ppublish
SO  - Nurse Res. 2010;18(1):15-25. doi: 10.7748/nr2010.10.18.1.15.c8044.


PMID- 21138080
OWN - NLM
STAT- MEDLINE
DCOM- 20101223
LR  - 20101208
IS  - 1351-5578 (Print)
IS  - 1351-5578 (Linking)
VI  - 18
IP  - 1
DP  - 2010
TI  - Ethical challenges in the conduct of qualitative research.
PG  - 4-7
FAU - Hegney, Desley
AU  - Hegney D
AD  - Alice Lee Centre for Nursing Studies, National University of Singapore.
FAU - Chan, Tuck Wai
AU  - Chan TW
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - England
TA  - Nurse Res
JT  - Nurse researcher
JID - 9435953
CON - Nurse Res. 2010;18(1):8-14. PMID: 21138081
CON - Nurse Res. 2010;18(1):15-25. PMID: 21138082
CON - Nurse Res. 2010;18(1):26-34. PMID: 21138083
MH  - Ethics, Research
MH  - Humans
MH  - Informed Consent/ethics
MH  - Nurse's Role
MH  - Nursing Methodology Research/*ethics
MH  - Patient Selection/ethics
MH  - Principle-Based Ethics
MH  - *Qualitative Research
MH  - Researcher-Subject Relations/ethics
EDAT- 2010/12/09 06:00
MHDA- 2010/12/25 06:00
CRDT- 2010/12/09 06:00
PHST- 2010/12/09 06:00 [entrez]
PHST- 2010/12/09 06:00 [pubmed]
PHST- 2010/12/25 06:00 [medline]
AID - 10.7748/nr2010.10.18.1.4.c8042 [doi]
PST - ppublish
SO  - Nurse Res. 2010;18(1):4-7. doi: 10.7748/nr2010.10.18.1.4.c8042.


PMID- 21138051
OWN - NLM
STAT- MEDLINE
DCOM- 20101228
LR  - 20190918
IS  - 0002-726X (Print)
IS  - 0002-726X (Linking)
VI  - 155
IP  - 3
DP  - 2010 Summer
TI  - Disability in higher education: a position paper.
PG  - 386-91
AB  - Leadership in education, particularly special education, implies both knowledge
      and application of professional behaviors, decisions, and ethics within the
      field. University students look for best practices in education to be modeled by 
      faculty; this, in turn, underscores a fundamental belief in inclusionary
      principles. Such modeling is important on every level in teacher education
      programs, particularly special education programs. The higher a student's level
      (i.e., undergraduate vs. doctoral), the more notice that student will take of
      disparities between rhetoric and actions. While reflective practices are
      explicitly taught in teacher preparation programs to enable professionals to
      reflect on their own personal and professional practices, teacher education
      faculty need to employ the same strategy to ensure that they are indeed modeling 
      the practices they teach. This position paper documents the impressions of a
      doctoral cohort in special education in terms of inclusionary practices
      demonstrated in a real-life context.
FAU - King, Laura H
AU  - King LH
AD  - Department of Curriculum and Instruction, Special Education Program Area, East
      Carolina University, Greenville, NC, USA.
FAU - Aguinaga, Nancy
AU  - Aguinaga N
FAU - O'Brien, Christopher
AU  - O'Brien C
FAU - Young, Willette
AU  - Young W
FAU - Zgonc, Kimberly
AU  - Zgonc K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am Ann Deaf
JT  - American annals of the deaf
JID - 0414670
SB  - IM
MH  - Communication
MH  - Comprehension
MH  - Curriculum
MH  - Disabled Persons/*education
MH  - *Education, Graduate
MH  - *Education, Special
MH  - Faculty
MH  - Humans
MH  - Leadership
MH  - Professional Role
MH  - Social Behavior
MH  - Students/*psychology
EDAT- 2010/12/09 06:00
MHDA- 2010/12/29 06:00
CRDT- 2010/12/09 06:00
PHST- 2010/12/09 06:00 [entrez]
PHST- 2010/12/09 06:00 [pubmed]
PHST- 2010/12/29 06:00 [medline]
AID - 10.1353/aad.2010.0019 [doi]
PST - ppublish
SO  - Am Ann Deaf. 2010 Summer;155(3):386-91. doi: 10.1353/aad.2010.0019.


PMID- 21138046
OWN - NLM
STAT- MEDLINE
DCOM- 20101228
LR  - 20190918
IS  - 0002-726X (Print)
IS  - 0002-726X (Linking)
VI  - 155
IP  - 3
DP  - 2010 Summer
TI  - Pediatric cochlear implantation: a qualitative study of parental decision-making 
      processes in Flanders, Belgium.
PG  - 339-52
AB  - Factors contributing to parents' decision when they choose between cochlear
      implantation (CI) and traditional hearing aids for their child were examined. The
      subjects were children with severe/profound hearing loss, born 1999-2001,
      registered in the universal neonatal hearing screening program in the Flanders
      region of Belgium. Qualitative data collected retrospectively from parents were
      subjected to thematic content analysis. In their responses to professional
      advice, parents were segmented into 3 groups: (a) those whose primary
      considerations were the importance of oral language development and the relative 
      potential of CI and traditional hearing aids; (b) those for whom alternative
      factors (e.g., medical risks, ethical issues) were paramount, even in the face of
      professional advocacy of CI; (c) those who followed professional advice against
      CI. The researchers conclude that care professionals should be sensitive to the
      impact of their advice and other factors in parental decision making.
FAU - Hardonk, Stefan
AU  - Hardonk S
AD  - Department of Medical Sociology, Vrije Universiteit Brussel, Brussels, Belgium.
      stefan.hardonk@vub.ac.be
FAU - Bosteels, Sigrid
AU  - Bosteels S
FAU - Desnerck, Greetje
AU  - Desnerck G
FAU - Loots, Gerrit
AU  - Loots G
FAU - Van Hove, Geert
AU  - Van Hove G
FAU - Van Kerschaver, Erwin
AU  - Van Kerschaver E
FAU - Vanroelen, Christophe
AU  - Vanroelen C
FAU - Louckx, Fred
AU  - Louckx F
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am Ann Deaf
JT  - American annals of the deaf
JID - 0414670
SB  - IM
MH  - Attitude of Health Personnel
MH  - Belgium
MH  - Child
MH  - Child, Preschool
MH  - Choice Behavior
MH  - Cochlear Implantation/adverse effects/*instrumentation/psychology
MH  - *Cochlear Implants
MH  - Correction of Hearing Impairment/*psychology
MH  - *Decision Making
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - *Hearing Aids
MH  - Humans
MH  - Male
MH  - Parents/*psychology
MH  - Persons With Hearing Impairments/*psychology/*rehabilitation
MH  - Professional-Family Relations
MH  - Qualitative Research
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Surveys and Questionnaires
EDAT- 2010/12/09 06:00
MHDA- 2010/12/29 06:00
CRDT- 2010/12/09 06:00
PHST- 2010/12/09 06:00 [entrez]
PHST- 2010/12/09 06:00 [pubmed]
PHST- 2010/12/29 06:00 [medline]
AID - 10.1353/aad.2010.0012 [doi]
PST - ppublish
SO  - Am Ann Deaf. 2010 Summer;155(3):339-52. doi: 10.1353/aad.2010.0012.


PMID- 21137536
OWN - NLM
STAT- MEDLINE
DCOM- 20101210
LR  - 20101222
IS  - 0023-7205 (Print)
IS  - 0023-7205 (Linking)
VI  - 107
IP  - 43
DP  - 2010 Oct 27-Nov 2
TI  - [The powerlessness of medical ethics].
PG  - 2658
FAU - Bodegard, Goran
AU  - Bodegard G
AD  - BUP-kliniken, Nordvastra sjukvardsomradet, Stockholm. goran.bodegard@comhem.se
LA  - swe
PT  - Journal Article
TT  - Den medicinska etikens kraftloshet.
PL  - Sweden
TA  - Lakartidningen
JT  - Lakartidningen
JID - 0027707
SB  - IM
CIN - Lakartidningen. 2010 Nov 3-9;107(44):2736. PMID: 21179885
MH  - Emigrants and Immigrants
MH  - *Ethics, Medical
MH  - Humans
MH  - Sweden
MH  - Transportation of Patients/ethics
EDAT- 2010/12/09 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/12/09 06:00
PHST- 2010/12/09 06:00 [entrez]
PHST- 2010/12/09 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - Lakartidningen. 2010 Oct 27-Nov 2;107(43):2658.


PMID- 21137532
OWN - NLM
STAT- MEDLINE
DCOM- 20101210
LR  - 20151119
IS  - 0023-7205 (Print)
IS  - 0023-7205 (Linking)
VI  - 107
IP  - 43
DP  - 2010 Oct 27-Nov 2
TI  - [Evacuation of severely ill from Balkan brought up the ethical dilemmas. Priority
      settings in an international aid project with relevance for Swedish health care].
PG  - 2640-3
FAU - Capusan, Andrea Johansson
AU  - Capusan AJ
AD  - Psykiatri och habilitering, Motala. andrea.capusan@lio.se
FAU - Bjorn, Ake
AU  - Bjorn A
FAU - Carlsson, Per
AU  - Carlsson P
LA  - swe
PT  - Journal Article
TT  - Evakueringar av svart sjuka fran Balkan satte etiska dilemman pa sin spets.
      Prioriteringar i ett bistandsprojekt med relevans for svensk sjukvard.
PL  - Sweden
TA  - Lakartidningen
JT  - Lakartidningen
JID - 0027707
SB  - IM
MH  - Bosnia and Herzegovina
MH  - Cost-Benefit Analysis
MH  - Decision Making/ethics
MH  - Health Priorities
MH  - Humans
MH  - *International Cooperation
MH  - *Patient Selection/ethics
MH  - Sweden
MH  - *Transportation of Patients/economics/ethics/organization & administration
MH  - Yugoslavia
EDAT- 2010/12/09 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/12/09 06:00
PHST- 2010/12/09 06:00 [entrez]
PHST- 2010/12/09 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - Lakartidningen. 2010 Oct 27-Nov 2;107(43):2640-3.


PMID- 21137488
OWN - NLM
STAT- MEDLINE
DCOM- 20110301
LR  - 20101207
IS  - 1268-6034 (Print)
IS  - 1268-6034 (Linking)
IP  - 85
DP  - 2010 Sep-Oct
TI  - [Seeking out this other person, demented but above all human].
PG  - 24-5
AB  - The nursing care given to "demented" people is now clearly written into law. From
      the gathering of facts about the patient's life history, to the planning of tasks
      to the drawing up of the care plan we seem to have available all the information 
      about them we need, with the exception of what remains of their human identity in
      the eyes of their family and the care workers. Thereby a simple comment made
      during a routine meeting with the son of a patient can throw up a multitude of
      ethical questions.
FAU - Antoun, May
AU  - Antoun M
AD  - Service d'une unite de soins de longue duree accueillant des malades atteints de 
      demence. mayantoun@orange.fr
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Aller a la rencontre de cet autre, dement mais avant tout humain.
PL  - France
TA  - Soins Gerontol
JT  - Soins. Gerontologie
JID - 9616322
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/*nursing/psychology
MH  - Ethics, Nursing
MH  - Family
MH  - Female
MH  - Humanism
MH  - Humans
MH  - Interpersonal Relations
EDAT- 2010/12/09 06:00
MHDA- 2011/03/02 06:00
CRDT- 2010/12/09 06:00
PHST- 2010/12/09 06:00 [entrez]
PHST- 2010/12/09 06:00 [pubmed]
PHST- 2011/03/02 06:00 [medline]
PST - ppublish
SO  - Soins Gerontol. 2010 Sep-Oct;(85):24-5.


PMID- 21137125
OWN - NLM
STAT- MEDLINE
DCOM- 20110120
LR  - 20101207
IS  - 0160-7480 (Print)
IS  - 0160-7480 (Linking)
VI  - 40
IP  - 47
DP  - 2010 Nov 22
TI  - Not yet in sequence: Clinical, technical, ethical questions linger over personal 
      genomics.
PG  - 24
FAU - Cho, Mildred
AU  - Cho M
AD  - Center for Integration of Research on Genetics and Ethics, Stanford University
      School of Medicine, Palo Alto, Calif., USA.
FAU - Wolpert, Maya
AU  - Wolpert M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Mod Healthc
JT  - Modern healthcare
JID - 7801798
MH  - *Biotechnology
MH  - *Clinical Laboratory Techniques
MH  - Genomics/*ethics
MH  - Humans
EDAT- 2010/12/09 06:00
MHDA- 2011/01/21 06:00
CRDT- 2010/12/08 06:00
PHST- 2010/12/08 06:00 [entrez]
PHST- 2010/12/09 06:00 [pubmed]
PHST- 2011/01/21 06:00 [medline]
PST - ppublish
SO  - Mod Healthc. 2010 Nov 22;40(47):24.


PMID- 21120345
OWN - NLM
STAT- MEDLINE
DCOM- 20110323
LR  - 20190907
IS  - 1678-4561 (Electronic)
IS  - 1413-8123 (Linking)
VI  - 15 Suppl 3
DP  - 2010 Nov
TI  - [User embracement in basic care: ethical implications on the health care of the
      users].
PG  - 3569-78
LID - S1413-81232010000900032 [pii]
AB  - This article identifies and analyses the ethical implications originated from the
      daily activities of user embracement in basic health units and its implications
      on the Health Care of the users of the Brazilian Unified Health System. It's a
      qualitative study of exploitative descriptive design which took place in 5 basic 
      health unit from city's health system of an important city in the state of Santa 
      Catarina (Brazil); 26 individuals have been interviewed, among them are managers,
      health employees and users. Analyzed in the light of the references of the daily 
      bioethics' and protection bioethics' approaches, the embracement in the cases
      studied revealed contexts filled with ethical conflicts which emerge from routine
      activities in health care, showing technical and conceptual distancing, as well
      as structural limitations. The user's statements pointed out outstanding
      differences between the users desire to feel embraced respectfully and having
      their needs accomplished and the frustrating experiences they experienced in the 
      basic health units' daily routine, which reveal situations of exclusion and
      denial on what concerns to the right to health. The results represent a setback
      in the implementation of this practice in accordance with the principles of
      universality in the access, integrality in care and the guarantee of the right to
      health.
FAU - Brehmer, Laura Cavalcanti de Farias
AU  - Brehmer LC
AD  - Universidade Federal de Santa Catarina, Florianopolis, SC.
      lauracavalcanti@bol.com.br
FAU - Verdi, Marta
AU  - Verdi M
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Acolhimento na Atencao Basica: reflexoes eticas sobre a Atencao a Saude dos
      usuarios.
PL  - Brazil
TA  - Cien Saude Colet
JT  - Ciencia & saude coletiva
JID - 9713483
SB  - IM
MH  - Brazil
MH  - Humans
MH  - Primary Health Care/*ethics
EDAT- 2010/12/09 06:00
MHDA- 2011/03/24 06:00
CRDT- 2010/12/02 06:00
PHST- 2007/12/11 00:00 [received]
PHST- 2009/02/26 00:00 [accepted]
PHST- 2010/12/02 06:00 [entrez]
PHST- 2010/12/09 06:00 [pubmed]
PHST- 2011/03/24 06:00 [medline]
AID - S1413-81232010000900032 [pii]
AID - 10.1590/s1413-81232010000900032 [doi]
PST - ppublish
SO  - Cien Saude Colet. 2010 Nov;15 Suppl 3:3569-78. doi:
      10.1590/s1413-81232010000900032.


PMID- 21120331
OWN - NLM
STAT- MEDLINE
DCOM- 20110323
LR  - 20191210
IS  - 1678-4561 (Electronic)
IS  - 1413-8123 (Linking)
VI  - 15 Suppl 3
DP  - 2010 Nov
TI  - [Sanitary control of alcohol advertisement in Brazil: a study of the law bills
      from 1988 to 2004].
PG  - 3433-42
LID - S1413-81232010000900018 [pii]
AB  - This study analyses law bills towards the sanitary control of alcohol
      advertisement in the mass media presented to the Brazilian Congress from 1988 to 
      2004. The sanitary control of this advertising is a controversial issue bringing 
      about an ethical-political debate in which the health-protecting interests
      conflict with commercial ones even after scientific evidence has established
      increasing alcohol intake as a health and social issue worldwide. The content
      analysis of 67 of such law bills was carried out, and these proposals were shown 
      to consist mostly of strategies to both cope with alcohol advertising by
      dissociating from the product those values that might interfere with the children
      and teenagers' building of their social identity and limit advertisement contents
      in the mass media given the higher vulnerability of the subjects in that age
      range. This study reveals complexes challenges for the control of alcohol
      advertisement that in turn lead to rethinking the action of the State apparatus
      in dealing with this major public health issue.
FAU - Falcao, Isa Cristina Lopes
AU  - Falcao IC
AD  - Coordenacao de Desenvolvimento Humano, Universidade Federal da Bahia, Salvador,
      BA. isa@ufba.br
FAU - Rangel-S, Maria Ligia
AU  - Rangel-S ML
LA  - por
PT  - Journal Article
TT  - Controle sanitario da propaganda de bebidas alcoolicas no Brasil: estudo dos
      projetos de lei de 1988 a 2004.
PL  - Brazil
TA  - Cien Saude Colet
JT  - Ciencia & saude coletiva
JID - 9713483
SB  - IM
MH  - Advertising/*legislation & jurisprudence
MH  - *Alcohol Drinking
MH  - Brazil
MH  - Social Control, Formal
MH  - Time Factors
EDAT- 2010/12/09 06:00
MHDA- 2011/03/24 06:00
CRDT- 2010/12/02 06:00
PHST- 2007/08/13 00:00 [received]
PHST- 2008/05/16 00:00 [accepted]
PHST- 2010/12/02 06:00 [entrez]
PHST- 2010/12/09 06:00 [pubmed]
PHST- 2011/03/24 06:00 [medline]
AID - S1413-81232010000900018 [pii]
AID - 10.1590/s1413-81232010000900018 [doi]
PST - ppublish
SO  - Cien Saude Colet. 2010 Nov;15 Suppl 3:3433-42. doi:
      10.1590/s1413-81232010000900018.


PMID- 21120330
OWN - NLM
STAT- MEDLINE
DCOM- 20110323
LR  - 20191210
IS  - 1678-4561 (Electronic)
IS  - 1413-8123 (Linking)
VI  - 15 Suppl 3
DP  - 2010 Nov
TI  - [Drug advertising to the general public: conceptual parameters of a risk producer
      practice].
PG  - 3423-31
LID - S1413-81232010000900017 [pii]
AB  - This article analyzes some concepts relating to marketing, advertising,
      medications, regulation and manipulation. It discusses ethical and health
      surveillance parameters of drugs advertising for the general public. The focus of
      this work is the analysis of contradictions from a conceptual point of view
      between the practice of pharmaceutical advertising as a tool for the increase of 
      sales and the conquest of markets versus the policy of rational use of medicines.
      Academic studies and monitoring of drugs advertising conducted by the National
      Health Surveillance Agency show that the contents of the advertising pieces
      oriented towards the general public overestimate the - sometimes dubious -
      qualities of their medication, focusing almost exclusively on the benefits and
      put them in a central position in the therapeutic process. They also fail to
      mention the risks inherent in their use. Rather than focusing on regulatory
      proposals aimed at creating constraints to this practice, this article discusses 
      the impossibility, considering the interests of public health, of the coexistence
      of marketing with the policies for the correct, rational and safe use of drugs.
FAU - Nascimento, Alvaro Cesar
AU  - Nascimento AC
AD  - Departamento de Ciencias Sociais, Escola Nacional de Saude, Fundacao Oswaldo
      Cruz, Rio de Janeiro, RJ. alvaron@ensp.fiocruz.br
LA  - por
PT  - Journal Article
TT  - Propaganda de medicamentos para grande publico: parametros conceituais de uma
      pratica produtora de risco.
PL  - Brazil
TA  - Cien Saude Colet
JT  - Ciencia & saude coletiva
JID - 9713483
SB  - IM
MH  - *Advertising
MH  - Brazil
MH  - *Drug Industry
MH  - Public Opinion
MH  - Risk
EDAT- 2010/12/09 06:00
MHDA- 2011/03/24 06:00
CRDT- 2010/12/02 06:00
PHST- 2009/07/22 00:00 [received]
PHST- 2009/09/28 00:00 [accepted]
PHST- 2010/12/02 06:00 [entrez]
PHST- 2010/12/09 06:00 [pubmed]
PHST- 2011/03/24 06:00 [medline]
AID - S1413-81232010000900017 [pii]
AID - 10.1590/s1413-81232010000900017 [doi]
PST - ppublish
SO  - Cien Saude Colet. 2010 Nov;15 Suppl 3:3423-31. doi:
      10.1590/s1413-81232010000900017.


PMID- 21137047
OWN - NLM
STAT- MEDLINE
DCOM- 20110729
LR  - 20151119
IS  - 1862-8354 (Electronic)
IS  - 1862-8346 (Linking)
VI  - 4
IP  - 3
DP  - 2010 Mar
TI  - Banking of clinical samples for proteomic biomarker studies: a consideration of
      logistical issues with a focus on pre-analytical variation.
PG  - 250-70
LID - 10.1002/prca.200900220 [doi]
AB  - Biobanks with their collections of clinical samples and data are essential
      resources for the success of clinical proteomics in delivering and validating
      candidate biomarkers. Samples must be banked in a manner that allows maximum
      subsequent compatibility with analytical techniques and additionally many
      critical factors must be taken into account when establishing a biobank or
      selecting samples from a biobank. These include logistical, ethical, legal and
      security issues and, very importantly, steps to minimise any pre-analytical
      variability introduced through sample processing and handling (technical
      effects). The inherent variation present within the samples must also be taken
      into account. In this review, we examine the impact of these factors and issues
      to be faced when banking samples with a particular focus on sources of
      pre-analytical variation, which must be rigorously controlled and recorded. It is
      encouraging that several initiatives are now addressing such key issues and these
      are also discussed.
CI  - Copyright (c) 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Jackson, David H
AU  - Jackson DH
AD  - Clinical and Biomedical Proteomics Group, Cancer Research UK Centre, Leeds
      Institute of Molecular Medicine, St. James's University Hospital, Leeds, UK.
FAU - Banks, Rosamonde E
AU  - Banks RE
LA  - eng
GR  - Cancer Research UK/United Kingdom
GR  - Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100107
PL  - Germany
TA  - Proteomics Clin Appl
JT  - Proteomics. Clinical applications
JID - 101298608
RN  - 0 (Biomarkers)
SB  - IM
MH  - Animals
MH  - *Artifacts
MH  - Biological Specimen Banks/ethics/*organization & administration
MH  - Biomarkers/*analysis/blood/urine
MH  - Humans
MH  - Proteomics/*methods/standards
MH  - Specimen Handling
EDAT- 2010/12/08 06:00
MHDA- 2011/07/30 06:00
CRDT- 2010/12/08 06:00
PHST- 2009/12/14 00:00 [received]
PHST- 2009/12/20 00:00 [revised]
PHST- 2009/12/20 00:00 [accepted]
PHST- 2010/12/08 06:00 [entrez]
PHST- 2010/12/08 06:00 [pubmed]
PHST- 2011/07/30 06:00 [medline]
AID - 10.1002/prca.200900220 [doi]
PST - ppublish
SO  - Proteomics Clin Appl. 2010 Mar;4(3):250-70. doi: 10.1002/prca.200900220. Epub
      2010 Jan 7.


PMID- 21136587
OWN - NLM
STAT- MEDLINE
DCOM- 20120320
LR  - 20111122
IS  - 1471-2865 (Electronic)
IS  - 1358-2267 (Linking)
VI  - 16
IP  - 4
DP  - 2011 Dec
TI  - Going global in physical therapist education: International Service-Learning in
      US-based programmes.
PG  - 225-36
LID - 10.1002/pri.501 [doi]
AB  - BACKGROUND AND PURPOSE: Internationalization is expanding its presence in higher 
      education in the United States. Reflecting this trend that includes incorporating
      global perspectives in the curricula, physical therapist education programmes
      increasingly offer international opportunities such as International
      Service-Learning (ISL) to their students. Service-learning, a teaching strategy
      that integrates community service with structured learning activities, has gained
      broad acceptance in health professions education including physical therapy, and 
      is therefore the focus of this paper. The specific purposes of this paper were to
      identify and analyse the commonalities that existed among established ISL
      programmes within physical therapist education programmes in terms of structures 
      and processes, and to consider its broader implications for physical therapist
      education. METHODS: A descriptive, exploratory study was performed using grounded
      theory. Snowball and purposive, theoretical sampling yielded 14 faculty members
      with experience in international service, international learning or ISL in
      physical therapist education programmes. Faculty were interviewed by phone.
      Interview transcriptions and course documents were analysed applying grounded
      theory methodology. Data from eight programmes which met the operational
      definition of established ISL were used to address the purposes of this paper.
      RESULTS: Five phases of establishing an ISL programme were identified:
      development, design, implementation, evaluation, and enhancement. Although no
      single model exists for ISL in physical therapist education; commonalities in
      structures and processes were identified in each phase. However, attention to
      service objectives and outcomes is lacking. CONCLUSIONS: While analysis revealed 
      that each programme shared commonalities and demonstrated differences in
      structures and processes compared with the other programmes, the study
      demonstrated a general lack of focus on formal community outcomes which raises
      ethical concerns. Future research and dialogue is warranted to explore ethics and
      good practice in ISL and other global health initiatives in physical therapy.
      This study may facilitate reflections and creative solutions by individual
      faculty and the profession.
CI  - Copyright (c) 2010 John Wiley & Sons, Ltd.
FAU - Pechak, Celia
AU  - Pechak C
AD  - Physical Therapy Program, University of Texas at El Paso, El Paso, Texas, USA.
      cmpechak@utep.edu
FAU - Thompson, Mary
AU  - Thompson M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101207
PL  - United States
TA  - Physiother Res Int
JT  - Physiotherapy research international : the journal for researchers and clinicians
      in physical therapy
JID - 9612022
SB  - IM
MH  - Curriculum
MH  - Education/*trends
MH  - Faculty
MH  - Humans
MH  - International Cooperation
MH  - *Internationality
MH  - Physical Therapists/*education
MH  - Physical Therapy Specialty/*trends
MH  - Program Development
MH  - Program Evaluation
MH  - United States
EDAT- 2010/12/08 06:00
MHDA- 2012/03/21 06:00
CRDT- 2010/12/08 06:00
PHST- 2010/07/19 00:00 [received]
PHST- 2010/10/01 00:00 [revised]
PHST- 2010/10/06 00:00 [accepted]
PHST- 2010/12/08 06:00 [entrez]
PHST- 2010/12/08 06:00 [pubmed]
PHST- 2012/03/21 06:00 [medline]
AID - 10.1002/pri.501 [doi]
PST - ppublish
SO  - Physiother Res Int. 2011 Dec;16(4):225-36. doi: 10.1002/pri.501. Epub 2010 Dec 7.


PMID- 21135025
OWN - NLM
STAT- MEDLINE
DCOM- 20110330
LR  - 20101220
IS  - 1744-5019 (Electronic)
IS  - 0360-5310 (Linking)
VI  - 35
IP  - 6
DP  - 2010 Dec
TI  - Contradictions from the enlightenment roots of transhumanism.
PG  - 622-40
LID - 10.1093/jmp/jhq049 [doi]
AB  - Transhumanism, the belief that technology can transcend the limitations of the
      human body and brain, is part of the family of Enlightenment philosophies. As
      such, transhumanism has also inherited the internal tensions and contradictions
      of the broad Enlightenment tradition. First, the project of Reason is
      self-erosive and requires irrational validation. Second, although most
      transhumanists are atheist, their belief in the transcendent power of
      intelligence generates new theologies. Third, although most transhumanists are
      liberal democrats, their belief in human perfectibility and governance by reason 
      can validate technocratic authoritarianism. Fourth, transhumanists are divided on
      the balance between democracy and the market. Fifth, teleological expectations of
      unstoppable progress are in tension with awareness of the indeterminacy of the
      future. Sixth, transhumanists are divided between advocates of ethical
      universalism and ethical relativism. Seventh, the rational materialist denial of 
      discrete persistent selves calls into question the transhumanist project of
      individual longevity and enhancement.
FAU - Hughes, James
AU  - Hughes J
AD  - Institute for Ethics and Emerging Technologies and Public Policy Studies, Trinity
      College, 300 Summit Street, Hartford, CT 06106, USA. director@ieet.org
LA  - eng
PT  - Journal Article
DEP - 20101206
PL  - United States
TA  - J Med Philos
JT  - The Journal of medicine and philosophy
JID - 7610512
SB  - IM
MH  - *Humanism
MH  - Humans
MH  - Intelligence
MH  - *Philosophy, Medical
MH  - Politics
MH  - Religion
EDAT- 2010/12/08 06:00
MHDA- 2011/03/31 06:00
CRDT- 2010/12/08 06:00
PHST- 2010/12/08 06:00 [entrez]
PHST- 2010/12/08 06:00 [pubmed]
PHST- 2011/03/31 06:00 [medline]
AID - jhq049 [pii]
AID - 10.1093/jmp/jhq049 [doi]
PST - ppublish
SO  - J Med Philos. 2010 Dec;35(6):622-40. doi: 10.1093/jmp/jhq049. Epub 2010 Dec 6.


PMID- 21134843
OWN - NLM
STAT- MEDLINE
DCOM- 20110401
LR  - 20181201
IS  - 2151-2396 (Electronic)
IS  - 0227-5910 (Linking)
VI  - 31
IP  - 5
DP  - 2010
TI  - Research participation experiences of informants of suicide and control cases:
      taken from a case-control psychological autopsy study of people who died by
      suicide.
PG  - 238-46
LID - 10.1027/0227-5910/a000025 [doi]
AB  - BACKGROUND: Ethical issues have been raised about using the psychological autopsy
      approach in the study of suicide. The impact on informants of control cases who
      participated in case-control psychological autopsy studies has not been
      investigated. AIMS: (1) To investigate whether informants of suicide cases
      recruited by two approaches (coroners' court and public mortuaries) respond
      differently to the initial contact by the research team. (2) To explore the
      reactions, reasons for participation, and comments of both the informants of
      suicide and control cases to psychological autopsy interviews. (3) To investigate
      the impact of the interviews on informants of suicide cases about a month after
      the interviews. METHODS: A self-report questionnaire was used for the informants 
      of both suicide and control cases. Telephone follow-up interviews were conducted 
      with the informants of suicide cases. RESULTS: The majority of the informants of 
      suicide cases, regardless of the initial route of contact, as well as the control
      cases were positive about being approached to take part in the study. A minority 
      of informants of suicide and control cases found the experience of talking about 
      their family member to be more upsetting than expected. The telephone follow-up
      interviews showed that none of the informants of suicide cases reported being
      distressed by the psychological autopsy interviews. LIMITATIONS: The acceptance
      rate for our original psychological autopsy study was modest. CONCLUSIONS: The
      findings of this study are useful for future participants and researchers in
      measuring the potential benefits and risks of participating in similar sensitive 
      research. Psychological autopsy interviews may be utilized as an active
      engagement approach to reach out to the people bereaved by suicide, especially in
      places where the postvention work is underdeveloped.
FAU - Wong, Paul W C
AU  - Wong PW
AD  - HKJC Centre for Suicide Research and Prevention, The University of Hong Kong,
      Pokfulam, Hong Kong SAR, P. R. China. paulw@hku.hk
FAU - Chan, Wincy S C
AU  - Chan WS
FAU - Beh, Philip S L
AU  - Beh PS
FAU - Yau, Fiona W S
AU  - Yau FW
FAU - Yip, Paul S F
AU  - Yip PS
FAU - Hawton, Keith
AU  - Hawton K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Canada
TA  - Crisis
JT  - Crisis
JID - 8218602
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Attitude to Health
MH  - Bereavement
MH  - *Case-Control Studies
MH  - Chi-Square Distribution
MH  - Coroners and Medical Examiners/ethics/organization & administration
MH  - Data Collection/ethics/methods
MH  - Family/*psychology
MH  - Female
MH  - Follow-Up Studies
MH  - Hong Kong/epidemiology
MH  - Humans
MH  - Interview, Psychological/methods
MH  - Male
MH  - Middle Aged
MH  - Mortuary Practice/ethics/organization & administration
MH  - Motivation
MH  - Research Design
MH  - Research Subjects/*psychology
MH  - Risk Assessment
MH  - *Self Report/statistics & numerical data
MH  - *Suicide/psychology/statistics & numerical data
EDAT- 2010/12/08 06:00
MHDA- 2011/04/02 06:00
CRDT- 2010/12/08 06:00
PHST- 2010/12/08 06:00 [entrez]
PHST- 2010/12/08 06:00 [pubmed]
PHST- 2011/04/02 06:00 [medline]
AID - N01H0L3150737R17 [pii]
AID - 10.1027/0227-5910/a000025 [doi]
PST - ppublish
SO  - Crisis. 2010;31(5):238-46. doi: 10.1027/0227-5910/a000025.


PMID- 21134593
OWN - NLM
STAT- MEDLINE
DCOM- 20110426
LR  - 20101207
IS  - 0151-9638 (Print)
IS  - 0151-9638 (Linking)
VI  - 137
IP  - 12
DP  - 2010 Dec
TI  - [Ethics and aesthetics].
PG  - 844-55
LID - 10.1016/j.annder.2010.09.010 [doi]
FAU - Penso-Assathiany, D
AU  - Penso-Assathiany D
AD  - dompenso@wanadoo.fr
FAU - Michaud, T
AU  - Michaud T
FAU - Halioua, B
AU  - Halioua B
FAU - Consoli, S
AU  - Consoli S
CN  - Groupe D'ethique de la Societe Francaise de Dermatologie
LA  - fre
PT  - Journal Article
TT  - L'intervention esthetique. Regards croises sur le consentement et l'information.
DEP - 20101016
PL  - France
TA  - Ann Dermatol Venereol
JT  - Annales de dermatologie et de venereologie
JID - 7702013
SB  - IM
MH  - Adult
MH  - Dermatology/*ethics
MH  - *Ethics, Medical
MH  - Female
MH  - Hippocratic Oath
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Male
MH  - Mental Competency/psychology
MH  - Middle Aged
MH  - Rejuvenation/psychology
MH  - Schizophrenia/diagnosis
MH  - Surgery, Plastic/*ethics
EDAT- 2010/12/08 06:00
MHDA- 2011/04/27 06:00
CRDT- 2010/12/08 06:00
PHST- 2010/06/10 00:00 [received]
PHST- 2010/09/05 00:00 [revised]
PHST- 2010/09/10 00:00 [accepted]
PHST- 2010/12/08 06:00 [entrez]
PHST- 2010/12/08 06:00 [pubmed]
PHST- 2011/04/27 06:00 [medline]
AID - S0151-9638(10)00409-6 [pii]
AID - 10.1016/j.annder.2010.09.010 [doi]
PST - ppublish
SO  - Ann Dermatol Venereol. 2010 Dec;137(12):844-55. doi:
      10.1016/j.annder.2010.09.010. Epub 2010 Oct 16.


PMID- 21134479
OWN - NLM
STAT- MEDLINE
DCOM- 20110328
LR  - 20110128
IS  - 1096-3634 (Electronic)
IS  - 1084-9521 (Linking)
VI  - 22
IP  - 1
DP  - 2011 Feb
TI  - What can Dictyostelium bring to the study of Pseudomonas infections?
PG  - 77-81
LID - 10.1016/j.semcdb.2010.11.006 [doi]
AB  - Bacterial infections are complex events. They are studied in a variety of simple 
      model systems, using mammalian or non-mammalian hosts, all of which fail to
      reproduce fully the situation in infected patients. Each model presents a
      combination of conceptual, practical, and ethical advantages and disadvantages.
      In this review, we detail the use of Dictyostelium discoideum amoebae as a model 
      to study Pseudomonas aeruginosa. More specifically, our aim is to explore what
      this additional model system can bring to our understanding of Pseudomonas
      infections. The study of interactions between Dictyostelium amoebae and
      Pseudomonas provides a view of the selection pressures exerted by environmental
      predators on Pseudomonas. It also represents a unique system to assess the
      virulence of very large numbers of Pseudomonas strains.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Lima, Wanessa C
AU  - Lima WC
AD  - Department of Cell Physiology and Metabolism, Faculty of Medicine, University of 
      Geneva, Geneva, Switzerland.
FAU - Lelong, Emmanuelle
AU  - Lelong E
FAU - Cosson, Pierre
AU  - Cosson P
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20101204
PL  - England
TA  - Semin Cell Dev Biol
JT  - Seminars in cell & developmental biology
JID - 9607332
SB  - IM
MH  - Animals
MH  - Dictyostelium/*microbiology
MH  - Ecosystem
MH  - Humans
MH  - Models, Biological
MH  - Pseudomonas aeruginosa/pathogenicity/*physiology
MH  - Virulence
EDAT- 2010/12/08 06:00
MHDA- 2011/03/29 06:00
CRDT- 2010/12/08 06:00
PHST- 2010/11/05 00:00 [received]
PHST- 2010/11/24 00:00 [revised]
PHST- 2010/11/29 00:00 [accepted]
PHST- 2010/12/08 06:00 [entrez]
PHST- 2010/12/08 06:00 [pubmed]
PHST- 2011/03/29 06:00 [medline]
AID - S1084-9521(10)00197-7 [pii]
AID - 10.1016/j.semcdb.2010.11.006 [doi]
PST - ppublish
SO  - Semin Cell Dev Biol. 2011 Feb;22(1):77-81. doi: 10.1016/j.semcdb.2010.11.006.
      Epub 2010 Dec 4.


PMID- 21134198
OWN - NLM
STAT- MEDLINE
DCOM- 20110525
LR  - 20110825
IS  - 1743-498X (Electronic)
IS  - 1743-4971 (Linking)
VI  - 7
IP  - 4
DP  - 2010 Dec
TI  - Teaching ethics in the operating theatre by small group teaching.
PG  - 240-3
LID - 10.1111/j.1743-498X.2010.00397.x [doi]
AB  - BACKGROUND: Ethics is an important topic for theatre staff. They work in a
      multidisciplinary team usually with an unconscious patient. Ethical dilemmas can 
      often arise during elective and emergency surgery. CONTEXT: The teaching of
      ethics for this arena is often neglected in favour of covering other surgical
      skills. There is some evidence from studies of surgical specialties that doctors 
      do not feel confident in applying their training in ethics in the clinical
      environment. INNOVATION: This paper suggests a format and describes teaching
      tools for conducting classroom small group teaching sessions on ethics suitable
      for the whole theatre team. It outlines some strategies that can be used to
      stimulate debate, and suggested ground rules to run the session smoothly.
      IMPLICATIONS: Teaching of ethics at undergraduate level can be reinforced by such
      small group sessions during clinical placements. A short time spent in the
      classroom discussing such issues is of great benefit to medical staff and
      patients in this often forgotten, but vitally important topic.
CI  - (c) Blackwell Publishing Ltd 2010.
FAU - Johnston, Carolyn
AU  - Johnston C
AD  - St Georges Hospital, London, UK. Carolyn_johnston@yahoo.co.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Teach
JT  - The clinical teacher
JID - 101227511
SB  - IM
MH  - Clinical Competence
MH  - Education, Medical, Undergraduate/methods
MH  - Ethics, Medical/*education
MH  - General Surgery/*education
MH  - *Group Processes
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - *Learning
MH  - *Operating Rooms
MH  - Role Playing
MH  - Students, Medical
MH  - Teaching/*methods
EDAT- 2010/12/08 06:00
MHDA- 2011/05/26 06:00
CRDT- 2010/12/08 06:00
PHST- 2010/12/08 06:00 [entrez]
PHST- 2010/12/08 06:00 [pubmed]
PHST- 2011/05/26 06:00 [medline]
AID - 10.1111/j.1743-498X.2010.00397.x [doi]
PST - ppublish
SO  - Clin Teach. 2010 Dec;7(4):240-3. doi: 10.1111/j.1743-498X.2010.00397.x.


PMID- 21134108
OWN - NLM
STAT- MEDLINE
DCOM- 20110531
LR  - 20211020
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 11
IP  - 1
DP  - 2011 Apr
TI  - Twenty years of human research ethics committees in the Baltic States.
PG  - 48-54
LID - 10.1111/j.1471-8847.2010.00288.x [doi]
AB  - Two decades have passed since the first attempts were made to establish
      systematic ethical review of human research in the Baltic States. Legally and
      institutionally much has changed. In this paper we provide an historical and
      structural overview of ethical review of human research and identify some
      problems related to the role of ethical review in establishing quality research
      environment in these countries. Problems connected to (a) public availability of 
      information, (b) management of conflicts of interest, (c) REC composition and
      motivation of REC members, and (d) differing levels of stringency of ethical
      review for different types of studies, are identified. Recommendations are made
      to strengthen cooperation among the Baltic RECs.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Dranseika, Vilius
AU  - Dranseika V
AD  - Department of Medical History and Ethics, Vilnius University, M.K. Ciurlionio St.
      21/27, Vilnius, Lithuania. vilius.dranseika@fsf.vu.lt
FAU - Gefenas, Eugenijus
AU  - Gefenas E
FAU - Cekanauskaite, Asta
AU  - Cekanauskaite A
FAU - Hug, Kristina
AU  - Hug K
FAU - Mezinska, Signe
AU  - Mezinska S
FAU - Peicius, Eimantas
AU  - Peicius E
FAU - Silis, Vents
AU  - Silis V
FAU - Soosaar, Andres
AU  - Soosaar A
FAU - Strosberg, Martin
AU  - Strosberg M
LA  - eng
GR  - R25 TW007085/TW/FIC NIH HHS/United States
GR  - R25 TW007085-07/TW/FIC NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20101207
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
SB  - IM
MH  - Baltic States
MH  - Clinical Trials as Topic/*ethics
MH  - Conflict of Interest
MH  - Ethical Analysis
MH  - Ethics Committees, Research/*trends
MH  - Ethics, Research
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Information Dissemination
PMC - PMC3072801
MID - NIHMS281034
EDAT- 2010/12/08 06:00
MHDA- 2011/06/01 06:00
CRDT- 2010/12/08 06:00
PHST- 2010/12/08 06:00 [entrez]
PHST- 2010/12/08 06:00 [pubmed]
PHST- 2011/06/01 06:00 [medline]
AID - 10.1111/j.1471-8847.2010.00288.x [doi]
PST - ppublish
SO  - Dev World Bioeth. 2011 Apr;11(1):48-54. doi: 10.1111/j.1471-8847.2010.00288.x.
      Epub 2010 Dec 7.


PMID- 21134054
OWN - NLM
STAT- MEDLINE
DCOM- 20110217
LR  - 20211203
IS  - 1753-6405 (Electronic)
IS  - 1326-0200 (Linking)
VI  - 34
IP  - 6
DP  - 2010 Dec
TI  - Respecting cultural values: conducting a gambling survey in an Australian
      Indigenous community.
PG  - 547-53
LID - 10.1111/j.1753-6405.2010.00624.x [doi]
AB  - OBJECTIVE: This paper details how we, as 'cultural outsiders', conducted a large 
      gambling survey in an Indigenous Australian community that adhered to Indigenous 
      ethical protocols and values while differing from some standard survey practices.
      APPROACH: The paper summarises the ethical guidelines for conducting Indigenous
      public health research. It describes research processes used in the study in
      eight generic steps identified in Keeping Research on Track: A Guide for
      Aboriginal and Torres Strait Islander Peoples About Health Research Ethics.(1) It
      explains how adherence to these guidelines contributed to successful project
      completion. CONCLUSION: The research processes used to conduct this project gave 
      explicit recognition and commitment to respecting Indigenous cultural values and 
      principles. It engaged the Indigenous community in ways that promoted its
      ownership of the research issue, ensured the validity and reliability of the
      research data and unearthed potential solutions to problems identified.
      IMPLICATIONS: By sharing our experiences in attempting to conduct research that
      respected these values and principles, we have contributed to culturally
      appropriate and ethical research with participating Indigenous peoples and
      communities.
CI  - (c) 2010 The Authors. ANZJPH (c) 2010 Public Health Association of Australia.
FAU - Hing, Nerilee
AU  - Hing N
AD  - Centre for Gambling Education and Research, Southern Cross University, Lismore,
      New South Wales. nerilee.hing@scu.edu.au
FAU - Breen, Helen
AU  - Breen H
FAU - Gordon, Ashley
AU  - Gordon A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101125
PL  - Australia
TA  - Aust N Z J Public Health
JT  - Australian and New Zealand journal of public health
JID - 9611095
SB  - IM
MH  - Australia
MH  - Community Participation
MH  - Culture
MH  - Data Collection/*methods
MH  - *Ethics, Research
MH  - Gambling/*ethnology
MH  - Guidelines as Topic
MH  - Health Surveys
MH  - Humans
MH  - Interviews as Topic
MH  - Native Hawaiian or Other Pacific Islander/psychology
MH  - *Public Health
MH  - Residence Characteristics
EDAT- 2010/12/08 06:00
MHDA- 2011/02/18 06:00
CRDT- 2010/12/08 06:00
PHST- 2010/12/08 06:00 [entrez]
PHST- 2010/12/08 06:00 [pubmed]
PHST- 2011/02/18 06:00 [medline]
AID - 10.1111/j.1753-6405.2010.00624.x [doi]
PST - ppublish
SO  - Aust N Z J Public Health. 2010 Dec;34(6):547-53. doi:
      10.1111/j.1753-6405.2010.00624.x. Epub 2010 Nov 25.


PMID- 21133978
OWN - NLM
STAT- MEDLINE
DCOM- 20110422
LR  - 20220311
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 25
IP  - 2
DP  - 2011 Feb
TI  - Moral enhancement and freedom.
PG  - 102-11
LID - 10.1111/j.1467-8519.2010.01854.x [doi]
AB  - This paper identifies human enhancement as one of the most significant areas of
      bioethical interest in the last twenty years. It discusses in more detail one
      area, namely moral enhancement, which is generating significant contemporary
      interest. The author argues that so far from being susceptible to new forms of
      high tech manipulation, either genetic, chemical, surgical or neurological, the
      only reliable methods of moral enhancement, either now or for the foreseeable
      future, are either those that have been in human and animal use for millennia,
      namely socialization, education and parental supervision or those high tech
      methods that are general in their application. By that is meant those forms of
      cognitive enhancement that operate across a wide range of cognitive abilities and
      do not target specifically 'ethical' capacities. The paper analyses the work of
      some of the leading contemporary advocates of moral enhancement and finds that in
      so far as they identify moral qualities or moral emotions for enhancement they
      have little prospect of success.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Harris, John
AU  - Harris J
AD  - University of Manchester, School of Law. john.harris@manchester.ac.uk
LA  - eng
GR  - 087439/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101207
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Biomedical Technology/*ethics
MH  - *Freedom
MH  - Humans
MH  - *Moral Development
MH  - Personal Autonomy
MH  - Religion and Science
MH  - Violence/*prevention & control
PMC - PMC3660783
EDAT- 2010/12/08 06:00
MHDA- 2011/04/26 06:00
CRDT- 2010/12/08 06:00
PHST- 2010/12/08 06:00 [entrez]
PHST- 2010/12/08 06:00 [pubmed]
PHST- 2011/04/26 06:00 [medline]
AID - 10.1111/j.1467-8519.2010.01854.x [doi]
PST - ppublish
SO  - Bioethics. 2011 Feb;25(2):102-11. doi: 10.1111/j.1467-8519.2010.01854.x. Epub
      2010 Dec 7.


PMID- 21133977
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20161125
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 26
IP  - 5
DP  - 2012 Jun
TI  - A direct advance on advance directives.
PG  - 267-74
LID - 10.1111/j.1467-8519.2010.01853.x [doi]
AB  - Advance directives (ADs), which are also sometimes referred to as 'living wills',
      are statements made by a person that indicate what treatment she should not be
      given in the event that she is not competent to consent or refuse at the future
      moment in question. As such, ADs provide a way for patients to make decisions in 
      advance about what treatments they do not want to receive, without doctors having
      to find proxy decision-makers or having recourse to the doctrine of necessity.
      While patients can request particular treatments in an AD, only refusals are
      binding. This paper will examine whether ADs safeguard the autonomy and best
      interests of the incompetent patient, and whether legislating for the use of ADs 
      is justified, using the specific context of the legal situation in the United
      Kingdom to illustrate the debate. The issue of whether the law should permit ADs 
      is itself dependent on the issue of whether ADs are ethically justified; thus we 
      must answer a normative question in order to answer the legislative one. It
      emerges that ADs suffer from two major problems, one related to autonomy and one 
      to consent. First, ADs' emphasis on precedent autonomy effectively sentences some
      people who want to live to death. Second, many ADs might not meet the standard
      criteria for informed refusal of treatment, because they fail on the crucial
      criterion of sufficient information. Ultimately, it transpires that ADs are
      typically only appropriate for patients who temporarily lose physical or mental
      capacity.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Shaw, David
AU  - Shaw D
AD  - School of Medicine of the University of Glasgow, Glasgow, Lanarkshire G2 3JZ, UK.
      david.shaw@glasgow.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20101207
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Advance Directives/*ethics/*legislation & jurisprudence
MH  - Humans
MH  - *Informed Consent/ethics/legislation & jurisprudence
MH  - Living Wills/ethics/legislation & jurisprudence
MH  - Mental Competency/legislation & jurisprudence
MH  - *Personal Autonomy
MH  - Terminal Care/ethics/legislation & jurisprudence
MH  - Treatment Refusal/*ethics/*legislation & jurisprudence
MH  - United Kingdom
EDAT- 2010/12/08 06:00
MHDA- 2012/09/21 06:00
CRDT- 2010/12/08 06:00
PHST- 2010/12/08 06:00 [entrez]
PHST- 2010/12/08 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
AID - 10.1111/j.1467-8519.2010.01853.x [doi]
PST - ppublish
SO  - Bioethics. 2012 Jun;26(5):267-74. doi: 10.1111/j.1467-8519.2010.01853.x. Epub
      2010 Dec 7.


PMID- 21133975
OWN - NLM
STAT- MEDLINE
DCOM- 20120820
LR  - 20120410
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 26
IP  - 4
DP  - 2012 May
TI  - The ethics of impossible and possible changes to human nature.
PG  - 191-7
LID - 10.1111/j.1467-8519.2010.01851.x [doi]
AB  - Some commentators speak freely about genetics being poised to change human
      nature. Contrary to such rhetoric, Norman Daniels believes no such thing is
      plausible since 'nature' describes characteristic traits of human beings as a
      whole. Genetic interventions that do their work one individual at a time are
      unlikely to change the traits of human beings as a class. Even so, one can
      speculate about ways in which human beings as a whole could be genetically
      altered, and there is nothing about that venture that could not be deliberated in
      the way other high-impact questions can be evaluated. There might well come a
      time when it would be defensible to use genetics to change human beings as a
      class, in order to protect people in the face of changed environmental
      circumstances or to enhance existing capacities. Moreover, if one understands
      human nature not in an empirically descriptive way but in a metaphysical way
      having implications about human behavior, it can make sense to talk about
      de-naturing individuals through genetic changes. Even under a metaphysical
      conception of human nature, however, one can still imagine that people in the
      future might want to alter their traits in pursuit of another normative idea of a
      good and valuable life, and genetic modifications might function as a pathway to 
      that change.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Murphy, Timothy F
AU  - Murphy TF
AD  - University of Illinois College of Medicine - Medical Education m/c 591, 808 S.
      Wood St., Chicago, Illinois 60612-7309, USA. tmurphy@uic.edu
LA  - eng
PT  - Journal Article
DEP - 20101207
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Genetic Engineering/*ethics
MH  - Genetic Enhancement/ethics
MH  - Genetic Research/ethics
MH  - *Human Characteristics
MH  - Humans
EDAT- 2010/12/08 06:00
MHDA- 2012/08/21 06:00
CRDT- 2010/12/08 06:00
PHST- 2010/12/08 06:00 [entrez]
PHST- 2010/12/08 06:00 [pubmed]
PHST- 2012/08/21 06:00 [medline]
AID - 10.1111/j.1467-8519.2010.01851.x [doi]
PST - ppublish
SO  - Bioethics. 2012 May;26(4):191-7. doi: 10.1111/j.1467-8519.2010.01851.x. Epub 2010
      Dec 7.


PMID- 21133974
OWN - NLM
STAT- MEDLINE
DCOM- 20120820
LR  - 20211203
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 26
IP  - 4
DP  - 2012 May
TI  - Whakapapa, genealogy and genetics.
PG  - 182-90
LID - 10.1111/j.1467-8519.2010.01850.x [doi]
AB  - This paper provides part of an analysis of the use of the Maori term whakapapa in
      a study designed to test the compatibility and commensurability of views of
      members of the indigenous culture of New Zealand with other views of genetic
      technologies extant in the country. It is concerned with the narrow sense of
      whakapapa as denoting biological ancestry, leaving the wider sense of whakapapa
      as denoting cultural identity for discussion elsewhere. The phenomenon of genetic
      curiosity is employed to facilitate this comparison. Four levels of curiosity are
      identified, in the Maori data, which penetrate more or less deeply into the
      psyche of individuals, affecting their health and wellbeing. These phenomena are 
      compared with non-Maori experiences and considerable commonalities are discovered
      together with a point of marked difference. The results raise important questions
      for the ethical application of genetic technologies.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Evans, Donald
AU  - Evans D
AD  - University of Otago Bioethics Centre, Medical and Surgical Sciences, PO Box 913
      Dunedin 9054, New Zealand. Donald.evans@otago.ac.nz
LA  - eng
PT  - Journal Article
DEP - 20101207
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - *Attitude
MH  - *Genealogy and Heraldry
MH  - Humans
MH  - *Native Hawaiian or Other Pacific Islander
MH  - New Zealand
MH  - *Pedigree
MH  - Reproductive Techniques/*ethics
MH  - *Social Identification
EDAT- 2010/12/08 06:00
MHDA- 2012/08/21 06:00
CRDT- 2010/12/08 06:00
PHST- 2010/12/08 06:00 [entrez]
PHST- 2010/12/08 06:00 [pubmed]
PHST- 2012/08/21 06:00 [medline]
AID - 10.1111/j.1467-8519.2010.01850.x [doi]
PST - ppublish
SO  - Bioethics. 2012 May;26(4):182-90. doi: 10.1111/j.1467-8519.2010.01850.x. Epub
      2010 Dec 7.


PMID- 21133789
OWN - NLM
STAT- MEDLINE
DCOM- 20110308
LR  - 20171116
IS  - 1556-2646 (Print)
IS  - 1556-2646 (Linking)
VI  - 5
IP  - 4
DP  - 2010 Dec
TI  - The research ethics committee is not the enemy: oversight of community-based
      participatory research.
PG  - 77-86
LID - 10.1525/jer.2010.5.4.77 [doi]
AB  - Researchers conducting community-based participatory research (CBPR) often
      complain about research ethics committee (REC) oversight of their research. RECs 
      may contribute to researchers' frustrations by seemingly focusing on form over
      substance and by failing to communicate effectively with researchers about their 
      mission and their specific concerns. UCSF CBPR researchers presented their views 
      of the UCSF REC's review of its tobacco use study in "It's Like Tuskegee in
      Reverse: A Case Study of Ethical Tensions in Institutional Review Board Review of
      Community-Based Participatory Research." This article builds on that case study
      by providing some perspectives from the REC side, identifying how the researchers
      and the REC came to be at odds, and seeking to bridge the gap between the CBPR
      and REC worlds. In particular, the article explores the different perspectives on
      who are human subjects under the federal regulations in CBPR research, who counts
      as the community, and the purpose of REC oversight. It offers concrete
      suggestions for improving the relationship between CBPR researchers and RECs.
FAU - Wolf, Leslie E
AU  - Wolf LE
AD  - Georgia State University College of Law, Atlanta, GA 30302-4037, USA.
      lwolf@gsu.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Community-Based Participatory Research/*ethics/legislation & jurisprudence
MH  - *Ethics Committees, Research
MH  - Human Experimentation/*ethics/legislation & jurisprudence
MH  - Humans
MH  - *Interprofessional Relations
MH  - Professional Role
MH  - *Risk Management
MH  - San Francisco
MH  - Smoking Prevention
EDAT- 2010/12/08 06:00
MHDA- 2011/03/09 06:00
CRDT- 2010/12/08 06:00
PHST- 2010/12/08 06:00 [entrez]
PHST- 2010/12/08 06:00 [pubmed]
PHST- 2011/03/09 06:00 [medline]
AID - 10.1525/jer.2010.5.4.77 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2010 Dec;5(4):77-86. doi: 10.1525/jer.2010.5.4.77.


PMID- 21133786
OWN - NLM
STAT- MEDLINE
DCOM- 20110308
LR  - 20101207
IS  - 1556-2646 (Print)
IS  - 1556-2646 (Linking)
VI  - 5
IP  - 4
DP  - 2010 Dec
TI  - Ethical challenges in a randomized controlled trial of peer education among
      veterans service organizations.
PG  - 43-51
LID - 10.1525/jer.2010.5.4.43 [doi]
AB  - Efforts to increase community members' involvement in research may create novel
      ethical challenges. We describe an ongoing randomized trial of a peer-delivered
      intervention to encourage hypertension self-management. Community members serving
      as peer leaders participate in subject recruitment, the informed consent process,
      and intervention. We describe our experience with several ethical issues that may
      arise when conducting research in similar settings: (1) coercion of community
      members, by the community, to participate either as leaders or as study subjects;
      (2) threats to the privacy of health information; and (3) conflict between peer
      leaders' roles as community members and study team members.
FAU - Whittle, Jeff
AU  - Whittle J
AD  - Clement J. Zablocki VA Medical Center, Milwaukee, WI 53295, USA.
      jeffrey.whittle@va.gov
FAU - Fletcher, Kathlyn E
AU  - Fletcher KE
FAU - Morzinski, Jeffrey
AU  - Morzinski J
FAU - Ertl, Kristyn
AU  - Ertl K
FAU - Patterson, Leslie
AU  - Patterson L
FAU - Jensen, Wayne
AU  - Jensen W
FAU - Schapira, Marilyn M
AU  - Schapira MM
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Community-Based Participatory Research/*ethics
MH  - Confidentiality/ethics
MH  - Humans
MH  - Hypertension/*therapy
MH  - Informed Consent/ethics
MH  - Patient Education as Topic/*methods
MH  - Patient Selection/ethics
MH  - *Peer Group
MH  - Personal Autonomy
MH  - Randomized Controlled Trials as Topic/*ethics
MH  - *Self Care
MH  - Social Support
MH  - Veterans
MH  - Wisconsin
EDAT- 2010/12/08 06:00
MHDA- 2011/03/09 06:00
CRDT- 2010/12/08 06:00
PHST- 2010/12/08 06:00 [entrez]
PHST- 2010/12/08 06:00 [pubmed]
PHST- 2011/03/09 06:00 [medline]
AID - 10.1525/jer.2010.5.4.43 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2010 Dec;5(4):43-51. doi: 10.1525/jer.2010.5.4.43.


PMID- 21133784
OWN - NLM
STAT- MEDLINE
DCOM- 20110308
LR  - 20101207
IS  - 1556-2646 (Print)
IS  - 1556-2646 (Linking)
VI  - 5
IP  - 4
DP  - 2010 Dec
TI  - Researchers' perspectives on collective/community co-authorship in
      community-based participatory indigenous research.
PG  - 23-32
LID - 10.1525/jer.2010.5.4.23 [doi]
AB  - Ethical tensions exist regarding the value and practice of acknowledging
      Indigenous contributions in community-based participatory research (CBPR).
      Semistructured phone interviews with researchers documented their perspectives on
      authorship in the scholarly dissemination of their community-based participatory 
      Indigenous research. Thematic analysis resulted in four key ideas: (1) current
      practices regarding methods of acknowledging community contributions; (2)
      requirements for shared authorship with individual versus collective/community
      partners; (3) benefits to sharing authorship with collective/community partners; 
      and (4) risks to sharing authorship with collective/community partners. Findings 
      suggest an emerging but inconsistent practice.
FAU - Castleden, Heather
AU  - Castleden H
AD  - School of Resource and Environmental Studies, Dalhousie University, Halifax, Nova
      Scotia, Canada. heather.castleden@dal.ca
FAU - Morgan, Vanessa Sloan
AU  - Morgan VS
FAU - Neimanis, Aelita
AU  - Neimanis A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - *Authorship
MH  - Canada
MH  - Community-Based Participatory Research/*ethics
MH  - Humans
MH  - *Indians, North American
MH  - *Inuits
MH  - Researcher-Subject Relations/*ethics
EDAT- 2010/12/08 06:00
MHDA- 2011/03/09 06:00
CRDT- 2010/12/08 06:00
PHST- 2010/12/08 06:00 [entrez]
PHST- 2010/12/08 06:00 [pubmed]
PHST- 2011/03/09 06:00 [medline]
AID - 10.1525/jer.2010.5.4.23 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2010 Dec;5(4):23-32. doi: 10.1525/jer.2010.5.4.23.


PMID- 21133783
OWN - NLM
STAT- MEDLINE
DCOM- 20110308
LR  - 20220330
IS  - 1556-2646 (Print)
IS  - 1556-2646 (Linking)
VI  - 5
IP  - 4
DP  - 2010 Dec
TI  - Research with Aboriginal peoples: authentic relationships as a precursor to
      ethical research.
PG  - 13-22
LID - 10.1525/jer.2010.5.4.13 [doi]
AB  - Recent ethics guidelines and policies are changing the way health research is
      understood, governed, and practiced among Aboriginal communities in Canada. This 
      provides a unique opportunity to examine the meanings and uses of such guidelines
      by Aboriginal communities themselves. This qualitative study, conducted in
      Labrador, Canada, with the Innu, Inuit, and Inuit-Metis, examined how communities
      and researchers collaborate in a co-learning environment whereby mutual interests
      and agendas are discussed and enacted throughout the entire research process-a
      process referred to an authentic research relationship. The purpose of this study
      was to answer the following questions: (1) Why are authentic research
      relationships important? (2) What is authenticity in research? (3) How do we
      achieve authenticity in research with Aboriginal peoples? This shift to more
      wholistic methodologies can be used in various contexts in Canada and
      internationally. This is the first study by an Aboriginal person to examine the
      perspectives of Aboriginal people, in an Aboriginal context, using Aboriginal
      methodologies.
FAU - Bull, Julie R
AU  - Bull JR
AD  - University of New Brunswick. Julie.bull@unb.ca
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Community-Based Participatory Research/*ethics/methods
MH  - Data Collection/ethics/methods
MH  - Guideline Adherence
MH  - Humans
MH  - Informed Consent/ethics
MH  - *Inuits
MH  - Newfoundland and Labrador
MH  - Researcher-Subject Relations/*ethics
EDAT- 2010/12/08 06:00
MHDA- 2011/03/09 06:00
CRDT- 2010/12/08 06:00
PHST- 2010/12/08 06:00 [entrez]
PHST- 2010/12/08 06:00 [pubmed]
PHST- 2011/03/09 06:00 [medline]
AID - 10.1525/jer.2010.5.4.13 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2010 Dec;5(4):13-22. doi: 10.1525/jer.2010.5.4.13.


PMID- 21133782
OWN - NLM
STAT- MEDLINE
DCOM- 20110308
LR  - 20101207
IS  - 1556-2646 (Print)
IS  - 1556-2646 (Linking)
VI  - 5
IP  - 4
DP  - 2010 Dec
TI  - Community research in other contexts: learning from sustainability science.
PG  - 3-11
LID - 10.1525/jer.2010.5.4.3 [doi]
AB  - In health research, community based participatory research (CBPR) has seen
      remarkable growth as an approach that overcomes many of the ethical concerns
      raised by traditional approaches. A community of CBPR scholars is now sharing
      ideas and devising new approaches to collaborative research. Yet, this is
      occurring in isolation from similar efforts using different nomenclature and
      occurring outside of health research areas. There is much to be gained by
      bringing these parallel discussions together. In sustainability science, for
      example, scholars are struggling with the question of how stakeholders and
      scientists can coproduce knowledge that offers useful solutions to complex and
      urgent environmental problems. Like CBPR in health, sustainability science is
      denigrated for perceived lack of rigor because of its applied problem focus and
      lack of positivist approach. Approaches to knowledge creation in sustainability
      science involve "new" ideas such as wicked problems and agent-based modeling,
      which would be equally applicable to CBPR. Interestingly, sustainability research
      is motivated less by recognition of the corrosive effects of the inequality of
      power than from frustration at how limited the impact of research has been, a
      perspective that might be useful in CBPR, particularly in conjunction with the
      use of some borrowed tools of sustainability science such as wicked problem
      analysis and agent-based modeling. Importantly, the example of sustainability
      science has the potential to keep CBPR from entering into a new orthodoxy of how 
      research should be done.
FAU - Silka, Linda
AU  - Silka L
AD  - Margaret Chase Smith Policy Center, University of Maine, Orono, ME 04469, USA.
      Silka@maine.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - *Community-Based Participatory Research
MH  - *Conservation of Natural Resources
MH  - Humans
MH  - *Interdisciplinary Communication
MH  - Maine
MH  - Models, Theoretical
MH  - Problem Solving
MH  - Research/education
EDAT- 2010/12/08 06:00
MHDA- 2011/03/09 06:00
CRDT- 2010/12/08 06:00
PHST- 2010/12/08 06:00 [entrez]
PHST- 2010/12/08 06:00 [pubmed]
PHST- 2011/03/09 06:00 [medline]
AID - 10.1525/jer.2010.5.4.3 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2010 Dec;5(4):3-11. doi: 10.1525/jer.2010.5.4.3.


PMID- 21133781
OWN - NLM
STAT- MEDLINE
DCOM- 20110308
LR  - 20101207
IS  - 1556-2646 (Print)
IS  - 1556-2646 (Linking)
VI  - 5
IP  - 4
DP  - 2010 Dec
TI  - Life is short, ethics is long.
PG  - 1-2
LID - 10.1525/jer.2010.5.4.1 [doi]
FAU - Sieber, Joan E
AU  - Sieber JE
LA  - eng
PT  - Editorial
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Community-Based Participatory Research/ethics/*trends
MH  - Humans
EDAT- 2010/12/08 06:00
MHDA- 2011/03/09 06:00
CRDT- 2010/12/08 06:00
PHST- 2010/12/08 06:00 [entrez]
PHST- 2010/12/08 06:00 [pubmed]
PHST- 2011/03/09 06:00 [medline]
AID - 10.1525/jer.2010.5.4.1 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2010 Dec;5(4):1-2. doi: 10.1525/jer.2010.5.4.1.


PMID- 21133773
OWN - NLM
STAT- MEDLINE
DCOM- 20110329
LR  - 20220311
IS  - 1753-8165 (Electronic)
IS  - 1753-8157 (Linking)
VI  - 35
IP  - 3-4
DP  - 2010 Sep-Dec
TI  - Environments for ageing, assistive technology and self-determination: ethical
      perspectives.
PG  - 200-10
LID - 10.3109/17538157.2010.528649 [doi]
AB  - The development of information and communication technologies for design of
      environments for ageing is of great importance considering demographic trends in 
      the future. There is a realistic hope for the preservation of self-determination 
      and independence in the long term. However, some risks like a gradual loss of
      privacy should not be underestimated. The article discusses some ethical problems
      within this context. At the same time, the article demonstrates that the
      development and implementation of these technologies might be discussed for
      instance under some ethical assumptions of personal self-responsibility as well
      as social responsibility for the widest independence in advanced age.
FAU - Remmers, Hartmut
AU  - Remmers H
AD  - University of Osnabrueck, Faculty of Human Studies, Albrechtstrasse 28,
      Osnebrueck, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Inform Health Soc Care
JT  - Informatics for health & social care
JID - 101475011
SB  - IM
MH  - *Aging
MH  - Confidentiality
MH  - Humans
MH  - Independent Living/*ethics
MH  - Personal Autonomy
MH  - Social Responsibility
MH  - Telemetry/*ethics
EDAT- 2010/12/08 06:00
MHDA- 2011/03/30 06:00
CRDT- 2010/12/08 06:00
PHST- 2010/12/08 06:00 [entrez]
PHST- 2010/12/08 06:00 [pubmed]
PHST- 2011/03/30 06:00 [medline]
AID - 10.3109/17538157.2010.528649 [doi]
PST - ppublish
SO  - Inform Health Soc Care. 2010 Sep-Dec;35(3-4):200-10. doi:
      10.3109/17538157.2010.528649.


PMID- 21133593
OWN - NLM
STAT- MEDLINE
DCOM- 20110404
LR  - 20220330
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Linking)
VI  - 11
IP  - 4
DP  - 2010
TI  - Knowledge and barriers towards cervical cancer screening among young women in
      Malaysia.
PG  - 867-73
AB  - OBJECTIVES: This study examined the level of knowledge and barriers towards
      cervical cancer screening of female university students. METHODOLOGY: A
      cross-sectional design was used for 287 female students at a tertiary institution
      located in Selangor, Malaysia. A name list of all students in the all faculties
      were obtained from each faculty's registrar and the ethics committee of the
      Faculty of Health and Life Sciences, approved the study. Respondents completed a 
      consent form before they were given the questionnaire consisting of four
      sections: socio-demographic characteristics (six questions); risk factor of
      cervical cancer (six); knowledge about cervical cancer and the Pap smear test
      (ten); and finally barriers to Pap screening (eleven). Data were analyzed using
      SPSS version 13. RESULTS: The prevalence of ever having had a Pap test was 6%.
      Majority of the participants had adequate knowledge about risk factors of
      cervical cancer. The highest knowledge about cervical cancer risk factor reported
      by the respondents was having more than one sex partner (77.5%), whereas the
      lowest was the relationship between HPV and cervical cancer (51.2%). Age, marital
      status, ethnicity, monthly family income and faculty were significantly
      associated with knowledge of cervical cancer screening (p=0.003; p=0.001;
      p=0.002; p=0.002; p=0.001 and p=0.002; respectively). The most common barriers of
      cervical cancer screening were the Pap smear test will make them worry (95.8%)
      whereas the least common barrier reported among participants was no encouragement
      from the partner (8.8%). CONCLUSION: Some misconceptions and barriers in uptaking
      Pap smear test are still serious problems among young women. Although knowledge
      about cervical cancer screening is adequate they have a very poor practice of Pap
      smear test. The introduction of reproductive health subjects is warranted for all
      university students.
FAU - Al-Naggar, Redhwan Ahmed
AU  - Al-Naggar RA
AD  - International Medical School, Management and Science University, Shah Alam,
      Malaysia.
FAU - Low, W Y
AU  - Low WY
FAU - Isa, Zaleha Md
AU  - Isa ZM
LA  - eng
PT  - Journal Article
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cross-Sectional Studies
MH  - Female
MH  - *Health Behavior
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Malaysia
MH  - Mass Screening/*psychology
MH  - Papanicolaou Test
MH  - Socioeconomic Factors
MH  - Surveys and Questionnaires
MH  - Uterine Cervical Neoplasms/*diagnosis
MH  - Vaginal Smears
MH  - Young Adult
EDAT- 2010/12/08 06:00
MHDA- 2011/04/05 06:00
CRDT- 2010/12/08 06:00
PHST- 2010/12/08 06:00 [entrez]
PHST- 2010/12/08 06:00 [pubmed]
PHST- 2011/04/05 06:00 [medline]
PST - ppublish
SO  - Asian Pac J Cancer Prev. 2010;11(4):867-73.


PMID- 21133563
OWN - NLM
STAT- MEDLINE
DCOM- 20110504
LR  - 20191210
IS  - 0022-0167 (Print)
IS  - 0022-0167 (Linking)
VI  - 57
IP  - 1
DP  - 2010 Jan
TI  - A preliminary report on a new measure: Internalization of the Model Minority Myth
      Measure (IM-4) and its psychological correlates among Asian American college
      students.
PG  - 114-27
LID - 10.1037/a0017871 [doi]
AB  - This investigation is a preliminary report on a new measure of internalization of
      the model minority myth. In 3 studies, there was evidence for the validation of
      the 15-item Internalization of the Model Minority Myth Measure (IM-4), with 2
      subscales. The Model Minority Myth of Achievement Orientation referred to the
      myth of Asian Americans' greater success than other racial minority groups
      associated with their stronger work ethics, perseverance, and drives to succeed. 
      The Model Minority Myth of Unrestricted Mobility referred to the myth of Asian
      Americans' greater success than other racial minority groups associated with
      their stronger belief in fairness of treatment and lack of perceived racism or
      barriers at school or work. The 2-subscale structure of the IM-4 was supported by
      a combination of exploratory and confirmatory factor analyses, with support of
      discriminant, convergent, and incremental validity, as well as internal
      reliability and stability over 2 weeks. The IM-4 is a new measure that taps into 
      a uniquely racialized experience of Asian Americans with research and clinical
      implications.
FAU - Yoo, Hyung Chol
AU  - Yoo HC
AD  - Asian Pacific American Studies, Arizona State University, P.O. Box 874902, Tempe,
      AZ 85287-4902, USA. yoo@asu.edu
FAU - Burrola, Kimberly S
AU  - Burrola KS
FAU - Steger, Michael F
AU  - Steger MF
LA  - eng
PT  - Journal Article
PT  - Validation Study
PL  - United States
TA  - J Couns Psychol
JT  - Journal of counseling psychology
JID - 2985124R
SB  - IM
MH  - Achievement
MH  - Adolescent
MH  - Asian Americans/*psychology
MH  - *Culture
MH  - Drive
MH  - Female
MH  - Humans
MH  - *Internal-External Control
MH  - Male
MH  - Minority Groups/*psychology
MH  - Motivation
MH  - Personality Inventory/*statistics & numerical data
MH  - Psychometrics/statistics & numerical data
MH  - Reproducibility of Results
MH  - Resilience, Psychological
MH  - Social Values
MH  - Statistics as Topic
MH  - *Stereotyping
MH  - Students/*psychology
MH  - Young Adult
EDAT- 2010/12/08 06:00
MHDA- 2011/05/05 06:00
CRDT- 2010/12/08 06:00
PHST- 2010/12/08 06:00 [entrez]
PHST- 2010/12/08 06:00 [pubmed]
PHST- 2011/05/05 06:00 [medline]
AID - 2010-00483-004 [pii]
AID - 10.1037/a0017871 [doi]
PST - ppublish
SO  - J Couns Psychol. 2010 Jan;57(1):114-27. doi: 10.1037/a0017871.


PMID- 21133364
OWN - NLM
STAT- MEDLINE
DCOM- 20111109
LR  - 20211020
IS  - 1520-4804 (Electronic)
IS  - 0022-2623 (Linking)
VI  - 54
IP  - 1
DP  - 2011 Jan 13
TI  - Evaluation of novel N1-methyl-2-phenylindol-3-ylglyoxylamides as a new chemotype 
      of 18 kDa translocator protein-selective ligand suitable for the development of
      positron emission tomography radioligands.
PG  - 366-73
LID - 10.1021/jm101230g [doi]
AB  - A novel series of N(1)-methyl-(2-phenylindol-3-yl)glyoxylamides, 19-31, designed 
      in accordance with our previously reported pharmacophore/topological model,
      showed high affinity for the 18 kDa translocator protein (TSPO) and paved the way
      for developing a new radiolabeled probe. Thus ligand 31,
      N,N-di-n-propyl-(N(1)-methyl-2-(4'-nitrophenyl)indol-3-yl)glyoxylamide, featuring
      the best combination of affinity and lipophilicity, was labeled with carbon-11
      for evaluation with positron emission tomography (PET) in monkey. After
      intravenous injection, [(11)C]31 entered brain to give a high proportion of
      TSPO-specific binding. These findings augur well for the future application of
      [(11)C]31 in humans. Consequently, the binding of 31 to human TSPO was tested on 
      samples of brain membranes from deceased subjects who through ethically approved 
      in vitro study had previously been established to be high-affinity binders
      (HABs), mixed-affinity binders (MABs), or low-affinity binders (LABs) for the
      known TSPO ligand, PBR28 (2). 31 showed high affinity for HABs, MABs, and LABs.
      In conclusion, [(11)C]31 represents a promising new chemotype for developing
      novel TSPO radioligands as biomarkers of neuroinflammation.
FAU - Pike, Victor W
AU  - Pike VW
AD  - Molecular Imaging Branch, National Institute of Mental Health, National
      Institutes of Health, Bethesda, Maryland 20892, United States. pikev@mail.nih.gov
FAU - Taliani, Sabrina
AU  - Taliani S
FAU - Lohith, Talakad G
AU  - Lohith TG
FAU - Owen, David R J
AU  - Owen DR
FAU - Pugliesi, Isabella
AU  - Pugliesi I
FAU - Da Pozzo, Eleonora
AU  - Da Pozzo E
FAU - Hong, Jinsoo
AU  - Hong J
FAU - Zoghbi, Sami S
AU  - Zoghbi SS
FAU - Gunn, Roger N
AU  - Gunn RN
FAU - Parker, Christine A
AU  - Parker CA
FAU - Rabiner, Eugenii A
AU  - Rabiner EA
FAU - Fujita, Masahiro
AU  - Fujita M
FAU - Innis, Robert B
AU  - Innis RB
FAU - Martini, Claudia
AU  - Martini C
FAU - Da Settimo, Federico
AU  - Da Settimo F
LA  - eng
GR  - ZIA MH002793-09/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20101206
PL  - United States
TA  - J Med Chem
JT  - Journal of medicinal chemistry
JID - 9716531
RN  - 0 (Amides)
RN  - 0 (Carbon Radioisotopes)
RN  - 0 (Indoles)
RN  - 0 (Ligands)
RN  - 0 (N,N-di-n-propyl-(N1-methyl-2-(4'-nitrophenyl)indol-3-yl)glyoxylamide)
RN  - 0 (Radiopharmaceuticals)
RN  - 0 (Receptors, GABA)
RN  - 0 (TSPO protein, human)
SB  - IM
MH  - Amides/*chemical synthesis/chemistry/pharmacokinetics
MH  - Animals
MH  - Binding, Competitive
MH  - Brain/metabolism
MH  - Carbon Radioisotopes
MH  - Humans
MH  - In Vitro Techniques
MH  - Indoles/*chemical synthesis/chemistry/pharmacokinetics
MH  - Kidney/metabolism
MH  - Ligands
MH  - Macaca mulatta
MH  - Positron-Emission Tomography
MH  - Radioligand Assay
MH  - Radiopharmaceuticals/*chemical synthesis/chemistry/pharmacokinetics
MH  - Rats
MH  - Receptors, GABA/*metabolism
MH  - Structure-Activity Relationship
PMC - PMC3135721
MID - NIHMS256999
EDAT- 2010/12/08 06:00
MHDA- 2011/11/10 06:00
CRDT- 2010/12/08 06:00
PHST- 2010/12/08 06:00 [entrez]
PHST- 2010/12/08 06:00 [pubmed]
PHST- 2011/11/10 06:00 [medline]
AID - 10.1021/jm101230g [doi]
PST - ppublish
SO  - J Med Chem. 2011 Jan 13;54(1):366-73. doi: 10.1021/jm101230g. Epub 2010 Dec 6.


PMID- 21133335
OWN - NLM
STAT- MEDLINE
DCOM- 20101222
LR  - 20191111
IS  - 1054-6863 (Print)
IS  - 1054-6863 (Linking)
VI  - 20
IP  - 3
DP  - 2010 Sep
TI  - Is equal moral consideration really compatible with unequal moral status?
PG  - 251-76
AB  - The issue of moral considerability, or how much moral importance a being's
      interests deserve, is one of the most important in animal ethics. Some leading
      theorists--most notably David DeGrazia--have argued that a principle of "equal
      moral consideration" is compatible with "unequal moral status." Such a position
      would reconcile the egalitarian force of equal consideration with more stringent 
      obligations to humans than animals. The article presents arguments that equal
      consideration is not compatible with unequal moral status, thereby forcing those 
      who would justify significantly different moral protections for humans and
      animals to argue for unequal consideration.
FAU - Rossi, John
AU  - Rossi J
AD  - Food and Drug Administration, Office of Pediatric Therapeutics, Silver Spring,
      MD, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Kennedy Inst Ethics J
JT  - Kennedy Institute of Ethics journal
JID - 9109135
SB  - IM
MH  - *Animal Rights
MH  - Animals
MH  - Humans
MH  - *Moral Obligations
MH  - Morals
MH  - *Personhood
EDAT- 2010/12/08 06:00
MHDA- 2010/12/24 06:00
CRDT- 2010/12/08 06:00
PHST- 2010/12/08 06:00 [entrez]
PHST- 2010/12/08 06:00 [pubmed]
PHST- 2010/12/24 06:00 [medline]
AID - 10.1353/ken.2010.0004 [doi]
PST - ppublish
SO  - Kennedy Inst Ethics J. 2010 Sep;20(3):251-76. doi: 10.1353/ken.2010.0004.


PMID- 21133333
OWN - NLM
STAT- MEDLINE
DCOM- 20101222
LR  - 20191111
IS  - 1054-6863 (Print)
IS  - 1054-6863 (Linking)
VI  - 20
IP  - 3
DP  - 2010 Sep
TI  - International stem cell tourism and the need for effective regulation. Part II:
      Developing sound oversight measures and effective patient support.
PG  - 207-30
AB  - Part I of this article, published in the March 2010 issue of the Kennedy
      Institute of Ethics Journal, traces and addresses the provision of unproven stem 
      cell treatments in Russia and India, examines the concept of innovative
      treatment, and concludes that stronger regulations are needed to protect the
      health and informed choices of patients. The current paper, Part II, proposes
      that the regulatory frameworks for the development of safe and efficacious
      treatments in effect in the United States and the United Kingdom provide examples
      of strong oversight measures from which countries seeking to obtain international
      credibility for their biotechnological competence could draw when developing
      regulations for stem cell treatments. Major sources of information available to
      persons who consider receiving such unproven treatments are explored in order to 
      understand and address their concerns. The paper concludes with proposed measures
      to inform those considering the pursuit of unproven stem cell treatments abroad
      more accurately about their efficacy and safety and provide them with improved
      medical and social support in their home countries.
FAU - Cohen, Cynthia B
AU  - Cohen CB
AD  - Kennedy Institute of Ethics, Georgetown University, Washington, DC, USA.
FAU - Cohen, Peter J
AU  - Cohen PJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Kennedy Inst Ethics J
JT  - Kennedy Institute of Ethics journal
JID - 9109135
SB  - IM
MH  - Biotechnology/ethics/*legislation & jurisprudence
MH  - Continuity of Patient Care
MH  - Humans
MH  - India
MH  - *International Cooperation
MH  - Medical Tourism/ethics/*legislation & jurisprudence
MH  - Russia
MH  - Social Support
MH  - Stem Cell Transplantation/ethics/*legislation & jurisprudence
MH  - United Kingdom
MH  - United States
EDAT- 2010/12/08 06:00
MHDA- 2010/12/24 06:00
CRDT- 2010/12/08 06:00
PHST- 2010/12/08 06:00 [entrez]
PHST- 2010/12/08 06:00 [pubmed]
PHST- 2010/12/24 06:00 [medline]
AID - 10.1353/ken.2010.0001 [doi]
PST - ppublish
SO  - Kennedy Inst Ethics J. 2010 Sep;20(3):207-30. doi: 10.1353/ken.2010.0001.


PMID- 21133239
OWN - NLM
STAT- MEDLINE
DCOM- 20101221
LR  - 20101207
IS  - 1029-4864 (Print)
IS  - 1029-4864 (Linking)
VI  - 65
IP  - 7
DP  - 2010 Aug
TI  - Dental ethics case 4. Good communication is key: how much do I tell a patient
      when things go wrong?
PG  - 328-9
FAU - Naidoo, S
AU  - Naidoo S
AD  - Department of Community Oral Health, University of the Western Cape, Tygerberg.
      suenaidoo@uwc.ac.za
FAU - Doyal, L
AU  - Doyal L
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - SADJ
JT  - SADJ : journal of the South African Dental Association = tydskrif van die
      Suid-Afrikaanse Tandheelkundige Vereniging
JID - 9812497
MH  - Dentist-Patient Relations/ethics
MH  - Disclosure/*ethics
MH  - *Ethics, Dental
MH  - Humans
MH  - Male
MH  - Medical Errors/*ethics
EDAT- 2010/12/08 06:00
MHDA- 2010/12/22 06:00
CRDT- 2010/12/08 06:00
PHST- 2010/12/08 06:00 [entrez]
PHST- 2010/12/08 06:00 [pubmed]
PHST- 2010/12/22 06:00 [medline]
PST - ppublish
SO  - SADJ. 2010 Aug;65(7):328-9.


PMID- 21133223
OWN - NLM
STAT- MEDLINE
DCOM- 20101228
LR  - 20101207
IS  - 1320-3185 (Print)
IS  - 1320-3185 (Linking)
VI  - 18
IP  - 4
DP  - 2010 Oct
TI  - Ethics, suffering, and altruism.
PG  - 23
FAU - Johnstone, Megan-Jane
AU  - Johnstone MJ
AD  - School of Nursing and Midwifery at Deakin University, Victoria.
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Aust Nurs J
JT  - Australian nursing journal (July 1993)
JID - 9317904
MH  - *Altruism
MH  - *Ethics, Nursing
MH  - Humans
MH  - *Stress, Psychological
EDAT- 2010/12/08 06:00
MHDA- 2010/12/29 06:00
CRDT- 2010/12/08 06:00
PHST- 2010/12/08 06:00 [entrez]
PHST- 2010/12/08 06:00 [pubmed]
PHST- 2010/12/29 06:00 [medline]
PST - ppublish
SO  - Aust Nurs J. 2010 Oct;18(4):23.


PMID- 21133213
OWN - NLM
STAT- MEDLINE
DCOM- 20101223
LR  - 20161125
IS  - 0029-6570 (Print)
IS  - 0029-6570 (Linking)
VI  - 25
IP  - 6
DP  - 2010 Oct 13-19
TI  - Management of diabetes in patients at the end of life.
PG  - 42-6
AB  - Diabetes is a complex metabolic disorder that is more common in patients with
      cancer than in the general population. The ethical dilemmas facing many
      healthcare professionals in the management of diabetes during the terminal phase 
      of life include the timing of withholding or withdrawing treatment. Communication
      can also be difficult between healthcare professionals, patients and their
      families at this time. If the patient's preferences have not been discussed at an
      earlier stage in the illness trajectory, mismanagement of diabetes may occur.
      Local protocols on diabetes management at the end of life have been developed in 
      some areas, but there are no national or standardised guidelines. This can result
      in fragmented care. This article explores the need for better communication and
      the development of national guidelines so that the quality of end of life care
      for patients with diabetes can be improved.
FAU - Budge, Pauline
AU  - Budge P
AD  - North Devon District Hospital, Barnstaple, North Devon.
      Pauline.budge@ndevon.swest.nhs.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Stand
JT  - Nursing standard (Royal College of Nursing (Great Britain) : 1987)
JID - 9012906
MH  - Communication
MH  - Diabetes Mellitus/nursing/*therapy
MH  - Humans
MH  - Hypoglycemia/therapy
MH  - Practice Guidelines as Topic
MH  - *Terminal Care
MH  - United Kingdom
EDAT- 2010/12/08 06:00
MHDA- 2010/12/25 06:00
CRDT- 2010/12/08 06:00
PHST- 2010/12/08 06:00 [entrez]
PHST- 2010/12/08 06:00 [pubmed]
PHST- 2010/12/25 06:00 [medline]
AID - 10.7748/ns2010.10.25.6.42.c8038 [doi]
PST - ppublish
SO  - Nurs Stand. 2010 Oct 13-19;25(6):42-6. doi: 10.7748/ns2010.10.25.6.42.c8038.


PMID- 21133055
OWN - NLM
STAT- MEDLINE
DCOM- 20101221
LR  - 20101207
IS  - 1029-4864 (Print)
IS  - 1029-4864 (Linking)
VI  - 65
IP  - 8
DP  - 2010 Sep
TI  - Dental ethics case 5. Child consent and the Children's Act (2005) as amended.
PG  - 382
FAU - Govan, P
AU  - Govan P
AD  - pgovan@sada.co.za
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - SADJ
JT  - SADJ : journal of the South African Dental Association = tydskrif van die
      Suid-Afrikaanse Tandheelkundige Vereniging
JID - 9812497
MH  - Adolescent
MH  - Child
MH  - Humans
MH  - Informed Consent By Minors/*legislation & jurisprudence
MH  - Minors/*legislation & jurisprudence
MH  - South Africa
EDAT- 2010/12/08 06:00
MHDA- 2010/12/22 06:00
CRDT- 2010/12/08 06:00
PHST- 2010/12/08 06:00 [entrez]
PHST- 2010/12/08 06:00 [pubmed]
PHST- 2010/12/22 06:00 [medline]
PST - ppublish
SO  - SADJ. 2010 Sep;65(8):382.


PMID- 21132945
OWN - HMD
STAT- MEDLINE
DCOM- 20110331
LR  - 20211203
IS  - 0002-7294 (Print)
IS  - 0002-7294 (Linking)
VI  - 112
IP  - 4
DP  - 2010
TI  - Torture by Cieng: ethical theory meets social practice among the Dinka Agaar of
      south Sudan.
PG  - 563-75
AB  - Here I detail violence in South Sudan by first discussing a specific Dinka Agaar 
      practice alongside existing discourses on the social aspects of violence and
      universal human rights, then I show how these acts had meaning and purpose using 
      data from personal accounts of violence. I posit that the violence described was 
      consistent with Dinka Agaar concepts of justice and basic human rights and that
      it cannot be judged against any universal human rights standard, devoid of local 
      context or of an overarching metanarrative. These events highlight conflicting
      subjectivities, ethical norms, and the painful difficulties inherent to advocacy 
      in areas of conflict. Viewed from the perspective of the larger social unit, it
      is easy to see how violence was required to end violence. However, witnessing
      punitive violence purposefully enacted on innocent individuals to achieve peace
      has the potential to create conflicting positions that modern anthropological
      discourse cannot reconcile.
FAU - Deal, Jeffery L
AU  - Deal JL
AD  - Medical University of South Carolina.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - Am Anthropol
JT  - American anthropologist
JID - 1275273
MH  - Anthropology/education/history
MH  - *Ethics/history
MH  - Ethnicity/education/ethnology/history/legislation & jurisprudence/psychology
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Human Rights/economics/education/history/legislation & jurisprudence/psychology
MH  - *Human Rights Abuses/economics/ethnology/history/legislation &
      jurisprudence/psychology
MH  - Humans
MH  - *Population Groups/education/ethnology/history/legislation &
      jurisprudence/psychology
MH  - *Social Control Policies/economics/history/legislation & jurisprudence
MH  - *Social Justice/economics/education/history/legislation &
      jurisprudence/psychology
MH  - Sudan/ethnology
MH  - *Torture/history/legislation & jurisprudence/psychology
MH  - Violence/economics/ethnology/history/legislation & jurisprudence/psychology
EDAT- 2010/12/08 06:00
MHDA- 2011/04/01 06:00
CRDT- 2010/12/08 06:00
PHST- 2010/12/08 06:00 [entrez]
PHST- 2010/12/08 06:00 [pubmed]
PHST- 2011/04/01 06:00 [medline]
AID - 10.1111/j.1548-1433.2010.01276.x [doi]
PST - ppublish
SO  - Am Anthropol. 2010;112(4):563-75. doi: 10.1111/j.1548-1433.2010.01276.x.


PMID- 21132596
OWN - NLM
STAT- MEDLINE
DCOM- 20110329
LR  - 20211203
IS  - 1552-4264 (Electronic)
IS  - 1552-4264 (Linking)
VI  - 6
IP  - 3-4
DP  - 2010
TI  - The influence of Latino ethnocultural factors on decision making at the end of
      life: withholding and withdrawing artificial nutrition and hydration.
PG  - 125-49
LID - 10.1080/15524256.2010.529009 [doi]
AB  - In this article, the author reviews the legal precedents that underpin the
      policies and practices found in most medical settings in relation to artificial
      nutrition and hydration (ANH) as the context for exploring the end-of-life (EOL) 
      care decision-making process of Latinos. The literature related to Latino beliefs
      and practices is reviewed. Specifically examined are the ways in which the values
      of familismo, filial duty, respect for authority figures, and personalismo play a
      major role in this group's decision-making process. Finally, the perspectives of 
      ethicists who argue that Western bioethical approaches fail to recognize that
      cultural norms and values as well as religious convictions play a significant
      role in shaping moral deliberations, including the decision to withdraw ANH from 
      individuals with a terminal illness, are explored. From a cross-cultural ethical 
      perspective, it is important for health care providers to understand that in a
      pluralistic society, patients and their families bring multiple models of healing
      and decision making to clinical encounters based on different cultural and
      religious values.
FAU - Del Rio, Norma
AU  - Del Rio N
AD  - San Francisco Department of Public Health, San Francisco, California, USA.
      nidelrio@aol.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Soc Work End Life Palliat Care
JT  - Journal of social work in end-of-life & palliative care
JID - 101235219
RN  - 059QF0KO0R (Water)
SB  - IM
MH  - *Culture
MH  - *Decision Making
MH  - Family
MH  - Hispanic or Latino/*psychology
MH  - Humans
MH  - Morals
MH  - Nutritional Support/ethics/psychology
MH  - Terminal Care/ethics/*psychology
MH  - Water
MH  - Withholding Treatment/*ethics
EDAT- 2010/12/07 06:00
MHDA- 2011/03/30 06:00
CRDT- 2010/12/07 06:00
PHST- 2010/12/07 06:00 [entrez]
PHST- 2010/12/07 06:00 [pubmed]
PHST- 2011/03/30 06:00 [medline]
AID - 930700606 [pii]
AID - 10.1080/15524256.2010.529009 [doi]
PST - ppublish
SO  - J Soc Work End Life Palliat Care. 2010;6(3-4):125-49. doi:
      10.1080/15524256.2010.529009.


PMID- 21132331
OWN - NLM
STAT- MEDLINE
DCOM- 20120328
LR  - 20211020
IS  - 1433-7339 (Electronic)
IS  - 0941-4355 (Linking)
VI  - 20
IP  - 1
DP  - 2012 Jan
TI  - How is cancer recently portrayed in Canadian newspapers compared to 20 years ago?
PG  - 49-55
LID - 10.1007/s00520-010-1049-9 [doi]
AB  - This study investigated cancer portrayals in newspapers now and 20 years ago. Six
      major daily newspapers from regions across Canada were studied. All articles from
      a 3-month period in 2008 (n = 576) and 1988 or 1989 (n = 412) focusing on cancer 
      were analyzed. Cancer is a more prevalent topic and is depicted in a more
      positive light in newspapers now when compared to 20 years ago. In 2008, the most
      common cancer-related themes were cancer research (27%), risk factors (26%),
      treatment (24%), education/prevention (20%), and fundraising events (19%).
      Compared to 1988/1989, in 2008, there was a significant decrease in articles
      covering the end of life and surgery, while there was a significant increase in
      articles portraying the senior population, male issues, individual stories
      depicting people suffering from cancer, the health care system, fundraising
      events, and ethics and law. The percentage of articles on psychosocial aspects of
      the cancer experience remained the same in 1988/1989 compared with 2008, with 16%
      of articles covering psychological aspects (vs. 17% in 2008), 5.6% social aspects
      (vs. 3.9% in 2008), and 0.2% spiritual aspects (vs. 0.5% in 2008). In 2008, few
      cancer articles spoke in-depth about palliative care (2.8%), issues concerning
      death and dying (5%), or bereavement (1%). Cancer newspaper reporting mostly
      focuses on the physical aspects of cancer rather than presenting a more holistic 
      approach including psychosocial issues. Implications of the shifts in tone and
      content of newspaper reporting are discussed. We highlight the importance of
      promoting coverage of distress as the sixth vital sign in newspaper press so as
      to inform readers about the experience of cancer and the existence of
      psychosocial services designed to optimize quality of life.
FAU - Henry, Melissa
AU  - Henry M
AD  - Department of Oncology, McGill University, Montreal, Quebec, Canada.
      melissa.henry@mgill.ca
FAU - Trickey, Brendan
AU  - Trickey B
FAU - Huang, Lina Nuoxin
AU  - Huang LN
FAU - Cohen, S Robin
AU  - Cohen SR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101204
PL  - Germany
TA  - Support Care Cancer
JT  - Supportive care in cancer : official journal of the Multinational Association of 
      Supportive Care in Cancer
JID - 9302957
SB  - IM
MH  - Canada
MH  - Delivery of Health Care/organization & administration
MH  - Humans
MH  - *Neoplasms/pathology/psychology/therapy
MH  - Newspapers as Topic/*trends
MH  - Quality of Life
EDAT- 2010/12/07 06:00
MHDA- 2012/03/29 06:00
CRDT- 2010/12/07 06:00
PHST- 2010/07/05 00:00 [received]
PHST- 2010/11/11 00:00 [accepted]
PHST- 2010/12/07 06:00 [entrez]
PHST- 2010/12/07 06:00 [pubmed]
PHST- 2012/03/29 06:00 [medline]
AID - 10.1007/s00520-010-1049-9 [doi]
PST - ppublish
SO  - Support Care Cancer. 2012 Jan;20(1):49-55. doi: 10.1007/s00520-010-1049-9. Epub
      2010 Dec 4.


PMID- 21132126
OWN - NLM
STAT- MEDLINE
DCOM- 20110908
LR  - 20131121
IS  - 0379-0355 (Print)
IS  - 0379-0355 (Linking)
VI  - 32
IP  - 8
DP  - 2010 Oct
TI  - Dobutamine-induced spontaneous rhythmic contractions of human isolated atrial
      strips mimic physiological responses of intact human heart.
PG  - 565-73
LID - 10.1358/mf.2010.32.8.1464032 [doi]
AB  - We have shown that in isolated human atrial strips the beta1-adrenoceptor agonist
      dobutamine can induce spontaneous, stable and durable rhythmic contractions. The 
      amplitude and frequency of these contractions were regulated endogenously by the 
      tissue. We tested whether the spontaneously contracted atrial strips could be
      used as an experimental assay model to determine inotropic and chronotropic
      effects of existing drugs and candidate chemicals directly on human heart muscle.
      The well-established inotropic and chronotropic effects of the calcium channel
      blocker (verapamil), the beta-adrenoceptor blocker (propranolol), the
      phosphodiesterase inhibitor (theophylline) and the Na(+)/K(+)-ATPase inhibitor
      (ouabain) were tested on spontaneously contracting strips of human atrium. With
      demonstrative tracings, we showed the negative inotropic and chronotropic effects
      of verapamil and propranolol, the positive inotropic and chronotropic effects of 
      theophylline and the transient inotropic and tachyarrhythmic effects of ouabain
      on dobutamine-pretreated human atrial strips. By using this method the
      undetermined inotropic and chronotropic effects of any candidate compound can be 
      evaluated directly on spontaneously contracting human atrial muscle. Furthermore,
      we demonstrated the advantages of using dobutamine instead of conventional
      electrical field stimulation in order to obtain stable and durable contractions
      of the atrial strips. In conclusion, we describe a new, simple, reliable,
      convenient and ethical method for investigating the inotropic and chronotropic
      effects of candidate drugs directly on human atrium tissue without the need for
      human test subjects.
CI  - Copyright 2010 Prous Science, S.A.U. or its licensors. All rights reserved.
FAU - Yenisehirli, A
AU  - Yenisehirli A
AD  - Department of Pharmacology, Faculty of Medicine, Gaziosmanpasa University, Tokat,
      Turkey. aydan@gop.edu.tr
FAU - Elalmis, O A
AU  - Elalmis OA
LA  - eng
PT  - Journal Article
PL  - Spain
TA  - Methods Find Exp Clin Pharmacol
JT  - Methods and findings in experimental and clinical pharmacology
JID - 7909595
RN  - 0 (Cardiotonic Agents)
RN  - 0 (Cardiovascular Agents)
RN  - 3S12J47372 (Dobutamine)
SB  - IM
MH  - Cardiotonic Agents/*pharmacology
MH  - Cardiovascular Agents/*pharmacology
MH  - Dobutamine/*pharmacology
MH  - Heart Atria/drug effects/metabolism
MH  - Heart Rate/drug effects
MH  - Humans
MH  - *Models, Biological
MH  - Myocardial Contraction/drug effects
MH  - Reproducibility of Results
EDAT- 2010/12/07 06:00
MHDA- 2011/09/09 06:00
CRDT- 2010/12/07 06:00
PHST- 2010/12/07 06:00 [entrez]
PHST- 2010/12/07 06:00 [pubmed]
PHST- 2011/09/09 06:00 [medline]
AID - 1464032 [pii]
AID - 10.1358/mf.2010.32.8.1464032 [doi]
PST - ppublish
SO  - Methods Find Exp Clin Pharmacol. 2010 Oct;32(8):565-73. doi:
      10.1358/mf.2010.32.8.1464032.


PMID- 21131717
OWN - NLM
STAT- MEDLINE
DCOM- 20110328
LR  - 20190513
IS  - 1930-6180 (Electronic)
IS  - 1084-2020 (Linking)
VI  - 51
IP  - 4
DP  - 2010
TI  - Guidelines and ethical considerations for housing and management of psittacine
      birds used in research.
PG  - 409-23
AB  - The Psittaciformes are a large order of landbirds comprising over 350 species in 
      about 83 genera. In 2009, 141 published studies implicated parrots as research
      subjects; in 31 of these studies, 483 individuals from 45 different species could
      be considered laboratory animals. Amazons and budgerigars were by far the most
      represented psittacine species. The laboratory research topics were categorized
      as either veterinary medicine and diagnostics (bacteriology, hematology,
      morphology, and reproduction; 45%) or behavioral and sensory studies (behavior,
      acoustics, and vision; 17%). Confinement of psittacine species for research
      purposes is a matter of concern as scientifically based species-specific housing 
      guidelines are scarce. The aim of this article is to provide scientific
      information relevant to the laboratory confinement of Psittaciformes to promote
      the refinement of acquisition, housing, and maintenance practices of these birds 
      as laboratory animals. We briefly discuss systematics, geographical distribution,
      legislation, and conservation status as background information on laboratory
      parrot confinement. The following section presents welfare concerns related to
      captive containment (including domestication status) and psittacine cognition. We
      then discuss considerations in the acquisition of laboratory parrots and review
      important management issues such as nutrition, zoonoses, housing, and
      environmental enrichment. The final section reviews indications of distress and
      compromised welfare.
FAU - Kalmar, Isabelle D
AU  - Kalmar ID
AD  - Laboratory of Animal Nutrition, Department of Nutrition, Genetics, and Ethology, 
      Ghent University, Heidestraat 19, 9820 Merelbeke, Belgium.
      isabelle.kalmar@ugent.be
FAU - Janssens, Geert P J
AU  - Janssens GP
FAU - Moons, Christel P H
AU  - Moons CP
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - ILAR J
JT  - ILAR journal
JID - 9516416
SB  - IM
MH  - Animal Welfare/ethics/standards
MH  - Animals
MH  - Ethics, Research
MH  - *Psittaciformes
MH  - *Research Design
EDAT- 2010/12/07 06:00
MHDA- 2011/03/29 06:00
CRDT- 2010/12/07 06:00
PHST- 2010/12/07 06:00 [entrez]
PHST- 2010/12/07 06:00 [pubmed]
PHST- 2011/03/29 06:00 [medline]
AID - 10.1093/ilar.51.4.409 [doi]
PST - ppublish
SO  - ILAR J. 2010;51(4):409-23. doi: 10.1093/ilar.51.4.409.


PMID- 21131610
OWN - NLM
STAT- MEDLINE
DCOM- 20110519
LR  - 20110217
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 3
DP  - 2011 Mar
TI  - What sort of bioethical values are the evidence-based medicine and the GRADE
      approaches willing to deal with?
PG  - 184-6
LID - 10.1136/jme.2010.039735 [doi]
AB  - The concept of evidence-based medicine (EBM) has been invented by physicians
      mostly from English Canada, mostly from McMaster University, Ontario, Canada. The
      term EBM first appeared in the biomedical literature in 1991 in an article
      written by a prominent member of this group-Gordon Guyatt from McMaster
      University. The inventors of EBM have also created the Grading of
      Recommendations, Assessment, Development and Evaluations (GRADE) working group,
      which is a prominent international organisation whose main purpose is to develop 
      evidence-based clinical practice guidelines (CPGs). CPGs that are based on the
      GRADE approach are becoming increasingly adopted worldwide, in particular by many
      professional or governmental organisations. This group of thinkers being thus
      identified, we have retrieved and read many of their publications in order to try
      and understand how they intend to incorporate bioethical values into their
      concept. The author of this little essay did also spend a few years on the
      internet as an active member of the GRADE group discussion list. The observations
      thus gathered suggest that although some of the inventors of EBM, at least Gordon
      Guyatt, wish to incorporate core principles of biomedical ethics into their
      concept (ie, non-malevolence, beneficence and maybe to a lesser extent respect
      for autonomy, and justice), some clarifications are still necessary in order to
      better understand how they intend to more explicitly incorporate bioethical
      values into their concept and, perhaps more importantly, into evidence-based
      CPGs.
FAU - Watine, Joseph
AU  - Watine J
AD  - Laboratoire de biologie polyvalente, Hopital de la Chartreuse, 12200
      Villefranche-de-Rouergue, France. joseph.watine@ch-villefranche-rouergue.fr
LA  - eng
PT  - Journal Article
DEP - 20101203
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Bioethical Issues
MH  - Clinical Trials as Topic/*ethics/standards
MH  - Evidence-Based Medicine/*ethics/standards
MH  - Humans
MH  - Ontario
MH  - Patient Rights/*ethics/standards
MH  - *Practice Guidelines as Topic/standards
EDAT- 2010/12/07 06:00
MHDA- 2011/05/20 06:00
CRDT- 2010/12/07 06:00
PHST- 2010/12/07 06:00 [entrez]
PHST- 2010/12/07 06:00 [pubmed]
PHST- 2011/05/20 06:00 [medline]
AID - jme.2010.039735 [pii]
AID - 10.1136/jme.2010.039735 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Mar;37(3):184-6. doi: 10.1136/jme.2010.039735. Epub 2010 Dec
      3.


PMID- 21131609
OWN - NLM
STAT- MEDLINE
DCOM- 20110523
LR  - 20211020
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 4
DP  - 2011 Apr
TI  - Choice is not the issue. The misrepresentation of healthcare in bioethical
      discourse.
PG  - 212-5
LID - 10.1136/jme.2010.039172 [doi]
AB  - The principle of respect for autonomy has shaped much of the bioethics' discourse
      over the last 50 years, and is now most commonly used in the meaning of
      respecting autonomous choice. This is probably related to the influential concept
      of informed consent, which originated in research ethics and was soon also
      applied to the field of clinical medicine. But while available choices in medical
      research are well defined, this is rarely the case in healthcare. Consideration
      of ordinary medical practice reveals that the focus on patient choice does not
      properly grasp the moral aspects involved in healthcare. Medical decisions are
      often portrayed as if doctors and patients in confidence confront specific
      decisions about examinations or treatment, yet the reality often involves many
      different participants, with decisions being made over time and space. Indeed,
      most of the decisions are never even presented to patients, as it would be
      unethical to suggest something that is not medically justifiable. The options
      patients do confront are somewhat arbitrarily constructed within the narrow
      framework of both what is deemed to be medically appropriate and how the
      healthcare system is organised practically. While the autonomy discourse has
      proven valuable, a failure to distinguish between the fields of medical research 
      and clinical medicine has generated a focus on patient choice that does not
      reflect what is really at stake in healthcare settings. This is alarming, because
      the current discourse misrepresents medical practice in a way that actually
      contributes to bioethical self-delusion.
FAU - Agledahl, Kari Milch
AU  - Agledahl KM
AD  - Finnmark Hospital Trust, Sykehusveien 35, 9613 Hammerfest, Norway.
      kari.agledahl@helse-finnmark.no
FAU - Forde, Reidun
AU  - Forde R
FAU - Wifstad, Age
AU  - Wifstad A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101203
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Bioethical Issues
MH  - Choice Behavior/ethics
MH  - Delivery of Health Care/*ethics
MH  - Humans
MH  - Informed Consent/*ethics
MH  - *Personal Autonomy
PMC - PMC3063455
EDAT- 2010/12/07 06:00
MHDA- 2011/05/24 06:00
CRDT- 2010/12/07 06:00
PHST- 2010/12/07 06:00 [entrez]
PHST- 2010/12/07 06:00 [pubmed]
PHST- 2011/05/24 06:00 [medline]
AID - jme.2010.039172 [pii]
AID - 10.1136/jme.2010.039172 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Apr;37(4):212-5. doi: 10.1136/jme.2010.039172. Epub 2010 Dec
      3.


PMID- 21131157
OWN - NLM
STAT- MEDLINE
DCOM- 20110418
LR  - 20191210
IS  - 1873-264X (Electronic)
IS  - 0731-7085 (Linking)
VI  - 54
IP  - 4
DP  - 2011 Mar 25
TI  - The use of human plasma as matrix for calibration standards in pre-clinical
      LC-MS/MS methods--a way to reduce animal use.
PG  - 826-9
LID - 10.1016/j.jpba.2010.11.009 [doi]
AB  - The option, for practical and ethical reasons, to replace animal plasma with
      human plasma for calibration standards was successfully applied to 73 analytical 
      methods developed in our laboratory during the last years. The animals used for
      obtaining blank plasma could then be reduced with a number corresponding to about
      25% of mice or 5% of rats in ordinary one-month toxicology studies. This is of
      important public concern and also in accordance with the 3R-strategy. The methods
      were successfully validated for determination of drug concentrations in plasma
      from rat, dog, mouse, rabbit and cynomolgus monkey. Reproducibility of study
      samples from dosed animals was established, showing a mean accuracy of 100.8%
      with a CV of 7.2% (n=1339). The purpose of this paper is to present a scientific 
      basis for the alternative approach to adopt human plasma matrix for calibration
      standards, which will reduce animal use, without compromising the quality of
      appropriately validated assays. Additional advantages are cheaper and simplified 
      plasma maintenance and the possibility to validate methods for several species in
      the same analytical batch.
CI  - Copyright (c) 2010 Elsevier B.V. All rights reserved.
FAU - Jacobson, Britt-Marie
AU  - Jacobson BM
AD  - Clinical Pharmacology & DMPK, AstraZeneca R&D Molndal, SE-431 83 Molndal, Sweden.
      britt-marie.jacobson@astrazeneca.com
FAU - Olsson, Anders
AU  - Olsson A
FAU - Fakt, Christina
AU  - Fakt C
FAU - Ohman, Daniel
AU  - Ohman D
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Validation Study
DEP - 20101113
PL  - England
TA  - J Pharm Biomed Anal
JT  - Journal of pharmaceutical and biomedical analysis
JID - 8309336
RN  - 0 (Drugs, Investigational)
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - *Animal Testing Alternatives
MH  - Animals
MH  - Calibration
MH  - Chromatography, High Pressure Liquid
MH  - Drug Evaluation, Preclinical/economics/*methods
MH  - Drug Stability
MH  - Drugs, Investigational/*analysis
MH  - Humans
MH  - Pharmaceutical Preparations/*blood
MH  - Reproducibility of Results
MH  - Spectrometry, Mass, Electrospray Ionization
MH  - Tandem Mass Spectrometry
MH  - Toxicity Tests/economics/methods
EDAT- 2010/12/07 06:00
MHDA- 2011/04/19 06:00
CRDT- 2010/12/07 06:00
PHST- 2010/09/16 00:00 [received]
PHST- 2010/11/03 00:00 [revised]
PHST- 2010/11/06 00:00 [accepted]
PHST- 2010/12/07 06:00 [entrez]
PHST- 2010/12/07 06:00 [pubmed]
PHST- 2011/04/19 06:00 [medline]
AID - S0731-7085(10)00652-7 [pii]
AID - 10.1016/j.jpba.2010.11.009 [doi]
PST - ppublish
SO  - J Pharm Biomed Anal. 2011 Mar 25;54(4):826-9. doi: 10.1016/j.jpba.2010.11.009.
      Epub 2010 Nov 13.


PMID- 21130630
OWN - NLM
STAT- MEDLINE
DCOM- 20110503
LR  - 20110111
IS  - 1769-664X (Electronic)
IS  - 0929-693X (Linking)
VI  - 18
IP  - 1
DP  - 2011 Jan
TI  - [Comments to M. Grassin and C. Dageville's article: ethics in neonatology].
PG  - 95-6; author reply 96
LID - 10.1016/j.arcped.2010.10.020 [doi]
FAU - Ropert, J-C
AU  - Ropert JC
LA  - fre
PT  - Comment
PT  - Letter
TT  - Commentaire de l'article de M. Grassin et C. Dageville sur l'ethique en
      neonatologie.
DEP - 20101203
PL  - France
TA  - Arch Pediatr
JT  - Archives de pediatrie : organe officiel de la Societe francaise de pediatrie
JID - 9421356
SB  - IM
CON - Arch Pediatr. 2010 Jul;17(7):997-9. PMID: 20447812
MH  - Humans
MH  - Infant, Newborn
MH  - Neonatology/*ethics
EDAT- 2010/12/07 06:00
MHDA- 2011/05/04 06:00
CRDT- 2010/12/07 06:00
PHST- 2010/09/29 00:00 [received]
PHST- 2010/10/21 00:00 [accepted]
PHST- 2010/12/07 06:00 [entrez]
PHST- 2010/12/07 06:00 [pubmed]
PHST- 2011/05/04 06:00 [medline]
AID - S0929-693X(10)00488-4 [pii]
AID - 10.1016/j.arcped.2010.10.020 [doi]
PST - ppublish
SO  - Arch Pediatr. 2011 Jan;18(1):95-6; author reply 96. doi:
      10.1016/j.arcped.2010.10.020. Epub 2010 Dec 3.


PMID- 21130547
OWN - NLM
STAT- MEDLINE
DCOM- 20120515
LR  - 20120117
IS  - 1532-3099 (Electronic)
IS  - 0266-6138 (Linking)
VI  - 28
IP  - 1
DP  - 2012 Feb
TI  - Reflexivity in midwifery research: the insider/outsider debate.
PG  - 52-60
LID - 10.1016/j.midw.2010.10.018 [doi]
AB  - OBJECTIVE: To explore the challenges of conducting an observational study of
      postnatal interactions, between midwives and women, when the researcher was a
      midwife observing in familiar midwifery settings. BACKGROUND: Participant
      observation conducted by researchers who are themselves midwives raises questions
      regarding the influence of 'identity' and 'insider' knowledge on the conduct of
      such projects. The insider/outsider status of researchers has been explored in
      other disciplines, yet this is an area which is underdeveloped in the midwifery
      literature where few attempts have been made to subject this issue to sustained
      analysis. DESIGN: A qualitative study (investigating the provision of
      breast-feeding support in the first week after birth) provided the opportunity
      for reflexive exploration of the tensions faced by midwife researchers. SETTING: 
      Two maternity units in New South Wales, Australia. PARTICIPANTS: Participants
      included 40 midwives and 78 breast-feeding women. FINDINGS: Possessing 'insider' 
      midwifery knowledge was advantageous in the 'getting in' and 'fitting in' phases 
      of this research study however unanticipated role ambiguity, and moral and
      ethical challenges, arose as a result of this 'insider' knowledge and status.
      Prolonged periods of observation challenged the midwife researcher's preconceived
      ideas and early decisions about the advantages and disadvantages of being an
      'insider' or an 'outsider' in the research setting. KEY CONCLUSIONS: Reflexive
      analysis of insider/outsider experiences revealed the middle ground which
      participant observers tend to navigate. Whilst professional insider knowledge and
      status offered many advantages, especially at the first study setting, some of
      the inherent embodied, and socially constructed features of the 'midwife'
      observer role, were unanticipated. Cultural competence, in these observational
      study settings, translated into role ambiguity, and at times, culturally
      entrenched role expectations. IMPLICATIONS FOR PRACTICE: Midwifery observation of
      clinical practice, for research, or practice development purposes, requires a
      degree of juggling of insider knowledge to facilitate observation and analysis.
      Prior to conducting observations midwives should consider how best to occupy the 
      middle ground between insider and outsider. Within the middle ground the midwife 
      can draw on those aspects of 'self' required to negotiate respectful
      relationships with colleagues, whilst also ensuring the maintenance of an
      analytical degree of distancing.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Burns, Elaine
AU  - Burns E
AD  - School of Nursing & Midwifery, College of Health & Science, University of Western
      Sydney, Locked Bag 1797, Penrith South DC, NSW 1797, Australia.
      e.burns@uws.edu.au
FAU - Fenwick, Jennifer
AU  - Fenwick J
FAU - Schmied, Virginia
AU  - Schmied V
FAU - Sheehan, Athena
AU  - Sheehan A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101204
PL  - Scotland
TA  - Midwifery
JT  - Midwifery
JID - 8510930
MH  - Adult
MH  - *Breast Feeding
MH  - *Clinical Competence
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Infant, Newborn
MH  - Job Description
MH  - New South Wales
MH  - *Nurse's Role
MH  - *Nurse-Patient Relations
MH  - *Nursing Methodology Research
MH  - Patient-Centered Care/methods
MH  - Postnatal Care/methods
MH  - Qualitative Research
MH  - Young Adult
EDAT- 2010/12/07 06:00
MHDA- 2012/05/16 06:00
CRDT- 2010/12/07 06:00
PHST- 2010/04/27 00:00 [received]
PHST- 2010/10/27 00:00 [revised]
PHST- 2010/10/31 00:00 [accepted]
PHST- 2010/12/07 06:00 [entrez]
PHST- 2010/12/07 06:00 [pubmed]
PHST- 2012/05/16 06:00 [medline]
AID - S0266-6138(10)00179-8 [pii]
AID - 10.1016/j.midw.2010.10.018 [doi]
PST - ppublish
SO  - Midwifery. 2012 Feb;28(1):52-60. doi: 10.1016/j.midw.2010.10.018. Epub 2010 Dec
      4.


PMID- 21130379
OWN - NLM
STAT- MEDLINE
DCOM- 20110302
LR  - 20101206
IS  - 1534-4436 (Electronic)
IS  - 1081-1206 (Linking)
VI  - 105
IP  - 6
DP  - 2010 Dec
TI  - The pulmonary index score as a clinical assessment tool for acute childhood
      asthma.
PG  - 425-9
LID - 10.1016/j.anai.2010.10.009 [doi]
AB  - BACKGROUND: Asthma in the pediatric population imposes a significant burden on
      the Australian health care system. The lack of a standardized asthma assessment
      tool is an area that needs to be addressed. OBJECTIVE: To validate the pulmonary 
      index score (PIS) against the National Asthma Council Guidelines (NACG) asthma
      assessment. METHODS: The project was approved by The Children's Hospital at
      Westmead Human Research Ethics Committee. Sixty-five patients aged 1 to 12 years 
      with acute asthma were assessed independently using both the PIS and the NACG on 
      presentation to the emergency department. RESULTS: These results indicate that
      the PIS (1) has high internal consistency (Cronbach alpha = .835); (2) correlates
      well with the NACG, with significant differences in PIS values across different
      NACG severity categories; (3) predicts with good sensitivity (85% for nonmild
      cases and 88% for severe cases) and specificity (75% for nonmild cases and 77%
      for severe cases) the various categories of asthma severity according to the
      NACG; and (4) significantly differs between admitted (mean PIS = 8.4) and
      nonadmitted (mean PIS = 5.0) patients. CONCLUSION: Use of the PIS may provide an 
      objective and standardized approach to the assessment and monitoring of asthma in
      children.
CI  - Copyright (c) 2010 American College of Allergy, Asthma & Immunology. Published by
      Elsevier Inc. All rights reserved.
FAU - Hsu, Peter
AU  - Hsu P
AD  - Emergency Department, Children's Hospital at Westmead, Sydney, Australia.
      shangyuh@gmail.com
FAU - Lam, Lawrence T
AU  - Lam LT
FAU - Browne, Gary
AU  - Browne G
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Ann Allergy Asthma Immunol
JT  - Annals of allergy, asthma & immunology : official publication of the American
      College of Allergy, Asthma, & Immunology
JID - 9503580
SB  - IM
MH  - Acute Disease
MH  - Asthma/*diagnosis
MH  - Australia
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Hospitals, Pediatric
MH  - Humans
MH  - Infant
MH  - Male
MH  - Practice Guidelines as Topic
MH  - Respiratory Rate
MH  - Sensitivity and Specificity
MH  - *Severity of Illness Index
EDAT- 2010/12/07 06:00
MHDA- 2011/03/03 06:00
CRDT- 2010/12/07 06:00
PHST- 2010/07/08 00:00 [received]
PHST- 2010/08/26 00:00 [revised]
PHST- 2010/10/10 00:00 [accepted]
PHST- 2010/12/07 06:00 [entrez]
PHST- 2010/12/07 06:00 [pubmed]
PHST- 2011/03/03 06:00 [medline]
AID - S1081-1206(10)00951-8 [pii]
AID - 10.1016/j.anai.2010.10.009 [doi]
PST - ppublish
SO  - Ann Allergy Asthma Immunol. 2010 Dec;105(6):425-9. doi:
      10.1016/j.anai.2010.10.009.


PMID- 21130346
OWN - NLM
STAT- MEDLINE
DCOM- 20110112
LR  - 20161125
IS  - 1097-6752 (Electronic)
IS  - 0889-5406 (Linking)
VI  - 138
IP  - 6
DP  - 2010 Dec
TI  - Litigation, legislation, and ethics. A few good questions.
PG  - 858-60
LID - 10.1016/j.ajodo.2010.07.016 [doi]
FAU - Jerrold, Laurance
AU  - Jerrold L
AD  - Orthodontic Consulting Group LLC, Jacksonville, Fla, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Orthod Dentofacial Orthop
JT  - American journal of orthodontics and dentofacial orthopedics : official
      publication of the American Association of Orthodontists, its constituent
      societies, and the American Board of Orthodontics
JID - 8610224
SB  - IM
MH  - Cephalometry
MH  - General Practice, Dental/*legislation & jurisprudence
MH  - Humans
MH  - Liability, Legal
MH  - Malocclusion/diagnosis/therapy
MH  - Malpractice/*legislation & jurisprudence
MH  - Orthodontic Appliances
MH  - Orthodontics/*legislation & jurisprudence
MH  - Patient Care Planning
MH  - Standard of Care/legislation & jurisprudence
MH  - Tooth Movement Techniques/instrumentation
MH  - United States
EDAT- 2010/12/07 06:00
MHDA- 2011/01/13 06:00
CRDT- 2010/12/07 06:00
PHST- 2010/06/01 00:00 [received]
PHST- 2010/06/01 00:00 [revised]
PHST- 2010/07/01 00:00 [accepted]
PHST- 2010/12/07 06:00 [entrez]
PHST- 2010/12/07 06:00 [pubmed]
PHST- 2011/01/13 06:00 [medline]
AID - S0889-5406(10)00731-6 [pii]
AID - 10.1016/j.ajodo.2010.07.016 [doi]
PST - ppublish
SO  - Am J Orthod Dentofacial Orthop. 2010 Dec;138(6):858-60. doi:
      10.1016/j.ajodo.2010.07.016.


PMID- 21129706
OWN - NLM
STAT- MEDLINE
DCOM- 20110301
LR  - 20191210
IS  - 1865-9217 (Print)
IS  - 1865-9217 (Linking)
VI  - 104
IP  - 8-9
DP  - 2010
TI  - [Physician rating sites from an ethical viewpoint: a roadmap].
PG  - 674-81
LID - 10.1016/j.zefq.2010.09.019 [doi]
AB  - BACKGROUND: Hardly any academic research has been conducted on physician rating
      sites (PRS) with regard to their medical and ethical implications. In the public 
      media, however, representatives of health care providers and payers have been
      involved in a controversial debate on the, at least, possible implications and
      practical consequences resulting from PRS. OBJECTIVES AND METHODS: The present
      article provides a conclusive explanation of why PRS can take on a significant
      role in future health care. Furthermore, using a framework of ethical principles,
      ethical and medical implications that can be related to PRS are systematically
      presented. RESULTS: Considering the so far rapid spread of Web 2.0 services, it
      seems plausible to assume that PRS will become a highly used source of
      information on selecting a physician. There are good reasons to believe that PRS 
      may have a positive impact on health outcomes of physician-seekers as well as on 
      the promotion of health literacy and equality of opportunity. However,
      considering the lack of evidence for these assumptions, the possibility of an
      opposite development should not be ruled out. The potential of damage for
      physician-seekers, for example, through misinformation, and for evaluated
      doctors, for example, caused by defamation, requires adequate prevention. On the 
      other hand, preventive measures should not restrict the attempts at optimising
      transparency of medical practice too strongly. DISCUSSION: Further specification 
      of the ethical principles outlined in the present article will significantly
      influence the upcoming decisions on the development and regulation
      (certification) of PRS. This raises complex normative considerations, the
      legitimacy of which can be enhanced by, among other things, adequate
      transparency, justification, participation and conflict of interest policies.
CI  - Copyright (c) 2010. Published by Elsevier GmbH.
FAU - Strech, Daniel
AU  - Strech D
AD  - Institut fur Geschichte, Ethik & Philosophie der Medizin, Medizinische Hochschule
      Hannover (MHH), Carl-Neuberg-Str. 1, 30625 Hannover. strech.daniel@mh-hannover.de
LA  - ger
PT  - Journal Article
TT  - Arztbewertungsportale aus ethischer Perspektive. Eine orientierende Analyse.
DEP - 20101008
PL  - Netherlands
TA  - Z Evid Fortbild Qual Gesundhwes
JT  - Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen
JID - 101477604
SB  - IM
MH  - Brief Psychiatric Rating Scale/*standards
MH  - Choice Behavior
MH  - *Ethics, Medical
MH  - Humans
MH  - Internet
MH  - Patient Selection
MH  - Patients/psychology
MH  - Physician-Patient Relations
MH  - Physicians/*standards
MH  - Power, Psychological
EDAT- 2010/12/07 06:00
MHDA- 2011/03/02 06:00
CRDT- 2010/12/07 06:00
PHST- 2010/05/18 00:00 [received]
PHST- 2010/09/08 00:00 [revised]
PHST- 2010/09/09 00:00 [accepted]
PHST- 2010/12/07 06:00 [entrez]
PHST- 2010/12/07 06:00 [pubmed]
PHST- 2011/03/02 06:00 [medline]
AID - S1865-9217(10)00262-X [pii]
AID - 10.1016/j.zefq.2010.09.019 [doi]
PST - ppublish
SO  - Z Evid Fortbild Qual Gesundhwes. 2010;104(8-9):674-81. doi:
      10.1016/j.zefq.2010.09.019. Epub 2010 Oct 8.


PMID- 21129539
OWN - NLM
STAT- MEDLINE
DCOM- 20110408
LR  - 20181201
IS  - 1531-5037 (Electronic)
IS  - 0022-3468 (Linking)
VI  - 45
IP  - 12
DP  - 2010 Dec
TI  - Current status of negative treatment decision-making for fetuses with a prenatal 
      diagnosis of neonatal surgical disease at a single Japanese institution.
PG  - 2328-33
LID - 10.1016/j.jpedsurg.2010.08.027 [doi]
AB  - BACKGROUND/PURPOSE: The termination of pregnancy because of fetal abnormalities
      in Japan has not been described. The aim of the present study was to analyze the 
      current status and to evaluate the medical and ethical relevance in our
      institution for negative treatment decision-making for fetuses demonstrating
      neonatal surgical disease with a prenatal diagnosis. MATERIALS AND METHODS: The
      medical records of 209 fetuses with a prenatal diagnosis from 1999 to 2008 were
      retrospectively reviewed. The cases with a negative treatment policy were
      analyzed according to the potential for survival. The negative treatment policies
      were defined as those in which the pregnancy was not actively continued,
      including elective termination of pregnancy and palliative or limited treatment
      that are primarily provided after birth. RESULTS: The selected treatment policies
      were active in 162 cases and negative in 46 cases. Thirty-three cases with
      negative policies were in the second-half period of pregnancy. The potential for 
      survival was high in 5 cases, moderate in 11 cases, and nonviable in 30 cases.
      Eight of the nonviable cases underwent either limited or palliative treatment,
      whereas the remaining 38 fetuses were aborted. CONCLUSIONS: The negative
      treatment policies in the nonviable fetuses were considered to be medically and
      ethically relevant. However, the number of cases with negative policies increased
      over the last 5 years and is therefore associated with complex ethical issues.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Usui, Noriaki
AU  - Usui N
AD  - Department of Pediatric Surgery, Osaka University Graduate School of Medicine,
      Osaka 565-0871, Japan. usui@pedsurg.med.osaka-u.ac.jp
FAU - Kanagawa, Takeshi
AU  - Kanagawa T
FAU - Kamiyama, Masafumi
AU  - Kamiyama M
FAU - Tani, Gakuto
AU  - Tani G
FAU - Kinugasa-Taniguchi, Yukiko
AU  - Kinugasa-Taniguchi Y
FAU - Kimura, Tadashi
AU  - Kimura T
FAU - Fukuzawa, Masahiro
AU  - Fukuzawa M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pediatr Surg
JT  - Journal of pediatric surgery
JID - 0052631
SB  - IM
MH  - Abortion, Eugenic/psychology/*statistics & numerical data
MH  - Congenital Abnormalities/diagnosis/*epidemiology
MH  - Decision Making
MH  - Female
MH  - Gestational Age
MH  - Hospitals, University/*statistics & numerical data
MH  - Humans
MH  - Japan/epidemiology
MH  - Organizational Policy
MH  - Palliative Care
MH  - Pregnancy
MH  - *Prenatal Diagnosis
MH  - Prognosis
EDAT- 2010/12/07 06:00
MHDA- 2011/04/09 06:00
CRDT- 2010/12/07 06:00
PHST- 2010/08/04 00:00 [received]
PHST- 2010/08/12 00:00 [accepted]
PHST- 2010/12/07 06:00 [entrez]
PHST- 2010/12/07 06:00 [pubmed]
PHST- 2011/04/09 06:00 [medline]
AID - S0022-3468(10)00702-5 [pii]
AID - 10.1016/j.jpedsurg.2010.08.027 [doi]
PST - ppublish
SO  - J Pediatr Surg. 2010 Dec;45(12):2328-33. doi: 10.1016/j.jpedsurg.2010.08.027.


PMID- 21129106
OWN - NLM
STAT- MEDLINE
DCOM- 20110323
LR  - 20101206
IS  - 1440-172X (Electronic)
IS  - 1322-7114 (Linking)
VI  - 16
IP  - 6
DP  - 2010 Dec
TI  - Towards a competency-based framework for nursing management education.
PG  - 545-54
LID - 10.1111/j.1440-172X.2010.01880.x [doi]
AB  - Defining a competency-based model for nursing management development will help to
      establish core competencies for nursing managers which will not only strengthen
      their practice and provide further learning and development opportunities, but
      will also provide the basis to focus training and professional development
      efforts. This paper identifies the competencies important for effective nursing
      management in the public and private health sectors. A total of 420 senior
      nursing managers in South Africa were surveyed using a self-administered
      questionnaire. Respondents had to rate the importance of 51 competency items as
      it pertains to effective nursing management. Self-management, controlling,
      health/clinical, organizing, people management, planning and ethical/legal
      competencies were found the most valuable for optimal nursing management. These
      findings reflect the reality of the nursing management milieu and will be useful 
      in the design and delivery of management development programmes aimed at
      enhancing nursing management capacity.
CI  - (c) 2010 Blackwell Publishing Asia Pty Ltd.
FAU - Pillay, Rubin
AU  - Pillay R
AD  - School of Entrepreneurship, Spears School of Business, Oklahoma State University,
      Stillwater, Oklahoma 74078, USA. rubin.pillay@okstate.edu
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Int J Nurs Pract
JT  - International journal of nursing practice
JID - 9613615
MH  - Adult
MH  - *Clinical Competence
MH  - Cross-Sectional Studies
MH  - *Education, Nursing
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nurses/*standards
MH  - South Africa
EDAT- 2010/12/07 06:00
MHDA- 2011/03/24 06:00
CRDT- 2010/12/07 06:00
PHST- 2010/12/07 06:00 [entrez]
PHST- 2010/12/07 06:00 [pubmed]
PHST- 2011/03/24 06:00 [medline]
AID - 10.1111/j.1440-172X.2010.01880.x [doi]
PST - ppublish
SO  - Int J Nurs Pract. 2010 Dec;16(6):545-54. doi: 10.1111/j.1440-172X.2010.01880.x.


PMID- 21129104
OWN - NLM
STAT- MEDLINE
DCOM- 20110323
LR  - 20220408
IS  - 1440-172X (Electronic)
IS  - 1322-7114 (Linking)
VI  - 16
IP  - 6
DP  - 2010 Dec
TI  - On being a good nurse: reflections on the past and preparing for the future.
PG  - 525-32
LID - 10.1111/j.1440-172X.2010.01878.x [doi]
AB  - The objectives of this paper include reflecting on the attributes of the 'good'
      nurse in the past, outlining thematically the essential attributes (virtues)
      required by the 'good' nurse today and presenting an original 4-point framework
      for ethics in practice. Although there is no doubt that nurses in the past were
      highly professional, the culture within which they practiced tended to stifle the
      emergence of autonomy, assertiveness, advocacy and accountability. An original
      table of contemporary attributes, which is congruent with a neo Aristotelian
      virtue ethical approach, is arranged in themes of Intellectual and Practical
      Attributes, Dispositional Attributes and Moral Attributes. A framework for
      professional practice, the 'Four As' is then extrapolated from these themes.
      These four key professional attributes, autonomy, advocacy, accountability and
      assertiveness, along with the virtues listed in the themes, exemplify the 'good' 
      nurse and are identified as the linchpins of modern professional ethics and good 
      conduct.
CI  - (c) 2010 Blackwell Publishing Asia Pty Ltd.
FAU - Begley, Ann M
AU  - Begley AM
AD  - Queen's University, School of Nursing and Midwifery, Belfast, UK.
      a.begley@qub.ac.uk
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Int J Nurs Pract
JT  - International journal of nursing practice
JID - 9613615
MH  - Ethics, Professional
MH  - Female
MH  - Humans
MH  - Male
MH  - Nurses/psychology/*standards
EDAT- 2010/12/07 06:00
MHDA- 2011/03/24 06:00
CRDT- 2010/12/07 06:00
PHST- 2010/12/07 06:00 [entrez]
PHST- 2010/12/07 06:00 [pubmed]
PHST- 2011/03/24 06:00 [medline]
AID - 10.1111/j.1440-172X.2010.01878.x [doi]
PST - ppublish
SO  - Int J Nurs Pract. 2010 Dec;16(6):525-32. doi: 10.1111/j.1440-172X.2010.01878.x.


PMID- 21129072
OWN - NLM
STAT- MEDLINE
DCOM- 20110401
LR  - 20171116
IS  - 1745-7599 (Electronic)
IS  - 1041-2972 (Linking)
VI  - 22
IP  - 12
DP  - 2010 Dec
TI  - T-cell prolymphocytic leukemia: A rare disease in an elderly female.
PG  - 648-53
LID - 10.1111/j.1745-7599.2010.00566.x [doi]
AB  - PURPOSE: To present a case report of an 83-year-old female with underlying
      dementia and a 1-2 month history of left upper quadrant pain. This report
      includes a review of the morphology of T-cell prolymphocytic leukemia (PLL),
      diagnosis, and the treatment options considered. DATA SOURCES: T-cell PLL is a
      rare blood disorder that represents a very small number of all chronic leukemias.
      An extensive review of scientific literature related to the cell morphology and
      pathology of this disease, as well as clinical trials of treatment options
      provided the background for this case report. CONCLUSION: A diagnosis of T-cell
      PLL was made after a computed tomography scan of the abdomen confirmed
      splenomegaly and a bone marrow biopsy showed a hypercellular marrow infiltrated
      with numerous small lymphocytes, consistent with this disease. Currently, there
      is no optimal treatment for T-cell PLL, but alemtuzumab has shown success with
      extending survival 1-3 years. IMPLICATIONS FOR PRACTICE: This case presented
      several ethical and practical challenges for this patient and her family in
      making a decision for chemotherapy treatment. This case underscores the need for 
      the physicians and nurse practitioners to establish a collaborative relationship 
      with patient, family, and other care providers when advocating for or against
      treatment.
CI  - (c)2010 The Author Journal compilation (c)2010 American Academy of Nurse
      Practitioners.
FAU - Madaris, Linda
AU  - Madaris L
AD  - University of South Florida, Tampa, Florida, USA. Linda.mad@verizon.net
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20101105
PL  - United States
TA  - J Am Acad Nurse Pract
JT  - Journal of the American Academy of Nurse Practitioners
JID - 8916634
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antibodies, Monoclonal, Humanized)
RN  - 0 (Antibodies, Neoplasm)
RN  - 0 (Antineoplastic Agents)
RN  - 3A189DH42V (Alemtuzumab)
MH  - Abdominal Pain/etiology
MH  - Aged, 80 and over
MH  - Alemtuzumab
MH  - Antibodies, Monoclonal/adverse effects/therapeutic use
MH  - Antibodies, Monoclonal, Humanized
MH  - Antibodies, Neoplasm/adverse effects/therapeutic use
MH  - Antineoplastic Agents/adverse effects/therapeutic use
MH  - Bone Marrow Examination
MH  - Dementia/complications
MH  - Fatal Outcome
MH  - Female
MH  - Humans
MH  - Leukemia, Prolymphocytic, T-Cell/complications/*diagnosis/*drug
      therapy/epidemiology
MH  - Nurse Practitioners
MH  - Patient Selection
MH  - Rare Diseases
MH  - Tomography, X-Ray Computed
EDAT- 2010/12/07 06:00
MHDA- 2011/04/02 06:00
CRDT- 2010/12/07 06:00
PHST- 2010/12/07 06:00 [entrez]
PHST- 2010/12/07 06:00 [pubmed]
PHST- 2011/04/02 06:00 [medline]
AID - 10.1111/j.1745-7599.2010.00566.x [doi]
PST - ppublish
SO  - J Am Acad Nurse Pract. 2010 Dec;22(12):648-53. doi:
      10.1111/j.1745-7599.2010.00566.x. Epub 2010 Nov 5.


PMID- 21128386
OWN - NLM
STAT- MEDLINE
DCOM- 20101223
LR  - 20190923
IS  - 1547-1896 (Print)
IS  - 0893-7400 (Linking)
VI  - 23
IP  - 10
DP  - 2010 Oct
TI  - Is it ethical to provide enteral tube feedings for patients with dementia?
PG  - 55-6
FAU - Hartsell, Zachary C
AU  - Hartsell ZC
AD  - Mayo Clinic, Arizona, USA.
FAU - Williams, Jennifer S
AU  - Williams JS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - JAAPA
JT  - JAAPA : official journal of the American Academy of Physician Assistants
JID - 9513102
MH  - Aged, 80 and over
MH  - Deglutition Disorders/*complications/*therapy
MH  - Dementia/*complications
MH  - Emergency Service, Hospital
MH  - Enteral Nutrition/*ethics
MH  - Female
MH  - Hospice Care
MH  - Humans
MH  - Palliative Care
EDAT- 2010/12/07 06:00
MHDA- 2010/12/25 06:00
CRDT- 2010/12/07 06:00
PHST- 2010/12/07 06:00 [entrez]
PHST- 2010/12/07 06:00 [pubmed]
PHST- 2010/12/25 06:00 [medline]
AID - 10.1097/01720610-201010000-00013 [doi]
PST - ppublish
SO  - JAAPA. 2010 Oct;23(10):55-6. doi: 10.1097/01720610-201010000-00013.


PMID- 21128218
OWN - NLM
STAT- MEDLINE
DCOM- 20110113
LR  - 20101203
IS  - 1422-4917 (Print)
IS  - 1422-4917 (Linking)
VI  - 38
IP  - 6
DP  - 2010 Nov
TI  - [Autonomy, care and justice: ethical aspects of the psychiatric treatment of
      adolescents].
PG  - 421-7
LID - 10.1024/1422-4917/a000071 [doi]
AB  - What is the right and good action in dealing with young patients in child and
      adolescent psychiatry? To answer this question, we have to consider professional 
      standards, legal rules, and ethical reflections. With reference to the latter,
      four bioethical principles were proposed by Beauchamp and Childress to identify
      and to deal with ethical problems and conflicts. On the basis of this scheme we
      reflect on the legal aspects and discuss the following topics: (1)
      self-determination of adolescents concerning their own psychiatric treatment, (2)
      conflicts between autonomy and care, which occur relatively often, whenever
      restrictions to personal liberty are indicated, and (3) admission of adolescents 
      in adult psychiatric wards. The bioethical principles facilitate a reliable
      decision-making process in individual cases. The standards of right and good
      action have to be implemented in the field of distributive justice. We find
      evidence that prioritization decisions for inpatient admission are already
      established in German child and adolescent psychiatry.
FAU - Hoger, Christoph
AU  - Hoger C
AD  - Klinik und Poliklinik fur Kinder- und Jugendpsychiatrie und Psychotherapie,
      Universitatsmedizin Gottingen. choeger@gwdg.de
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Autonomie, Fursorge und Gerechtigkeit1.
PL  - Switzerland
TA  - Z Kinder Jugendpsychiatr Psychother
JT  - Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie
JID - 9801717
SB  - IM
MH  - Adolescent
MH  - Adolescent Psychiatry/*ethics/legislation & jurisprudence
MH  - Adult
MH  - Age Factors
MH  - Child
MH  - Child Psychiatry/*ethics/legislation & jurisprudence
MH  - Commitment of Mentally Ill/legislation & jurisprudence
MH  - Confidentiality/ethics/legislation & jurisprudence
MH  - *Ethics, Medical
MH  - Germany
MH  - Hospital Bed Capacity
MH  - Humans
MH  - Length of Stay/legislation & jurisprudence
MH  - Mental Disorders/diagnosis/psychology/*therapy
MH  - Parental Notification/ethics/legislation & jurisprudence
MH  - Patient Admission/legislation & jurisprudence
MH  - Patient Rights/*ethics/legislation & jurisprudence
MH  - *Personal Autonomy
MH  - Psychiatric Department, Hospital/ethics/legislation & jurisprudence
EDAT- 2010/12/04 06:00
MHDA- 2011/01/14 06:00
CRDT- 2010/12/04 06:00
PHST- 2010/12/04 06:00 [entrez]
PHST- 2010/12/04 06:00 [pubmed]
PHST- 2011/01/14 06:00 [medline]
AID - kij_38_6_421 [pii]
AID - 10.1024/1422-4917/a000071 [doi]
PST - ppublish
SO  - Z Kinder Jugendpsychiatr Psychother. 2010 Nov;38(6):421-7. doi:
      10.1024/1422-4917/a000071.


PMID- 21127880
OWN - NLM
STAT- MEDLINE
DCOM- 20110913
LR  - 20220316
IS  - 1432-1084 (Electronic)
IS  - 0938-7994 (Linking)
VI  - 21
IP  - 6
DP  - 2011 Jun
TI  - Neoadjuvant chemotherapy in breast cancer-response evaluation and prediction of
      response to treatment using dynamic contrast-enhanced and diffusion-weighted MR
      imaging.
PG  - 1188-99
LID - 10.1007/s00330-010-2020-3 [doi]
AB  - OBJECTIVE: To explore the predictive value of MRI parameters and tumour
      characteristics before neoadjuvant chemotherapy (NAC) and to compare changes in
      tumour size and tumour apparent diffusion coefficient (ADC) during treatment,
      between patients who achieved pathological complete response (pCR) and those who 
      did not. METHODS: Approval by the Regional Ethics Committee and written informed 
      consent were obtained. Thirty-one patients with invasive breast carcinoma
      scheduled for NAC were enrolled (mean age, 50.7; range, 37-72). Study design
      included MRI before treatment (Tp0), after four cycles of NAC (Tp1) and before
      surgery (Tp2). Data in pCR versus non-pCR groups were compared and cut-off values
      for pCR prediction were evaluated. RESULTS: Before NAC, HER2 overexpression was
      the single significant predictor of pCR (p = 0.006). At Tp1 ADC, tumour size and 
      changes in tumour size were all significantly different in the pCR and non-pCR
      groups. Using 1.42 x 10(-3) mm(2)/s as the cut-off value for ADC, pCR was
      predicted with sensitivity and specificity of 88% and 80%, respectively. Using a 
      cut-off value of 83% for tumour volume reduction, sensitivity and specificity for
      pCR were 91% and 80%. CONCLUSION: ADC, tumour size and tumour size reduction at
      Tp1 were strong independent predictors of pCR.
FAU - Fangberget, A
AU  - Fangberget A
AD  - Department of Radiology and Nuclear Medicine, Norwegian Radium Hospital, Oslo
      University Hospital, Montebello, 0310, Oslo, Norway.
      anne.fangberget@radiumhospitalet.no
FAU - Nilsen, L B
AU  - Nilsen LB
FAU - Hole, K H
AU  - Hole KH
FAU - Holmen, M M
AU  - Holmen MM
FAU - Engebraaten, O
AU  - Engebraaten O
FAU - Naume, B
AU  - Naume B
FAU - Smith, H-J
AU  - Smith HJ
FAU - Olsen, D R
AU  - Olsen DR
FAU - Seierstad, T
AU  - Seierstad T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101203
PL  - Germany
TA  - Eur Radiol
JT  - European radiology
JID - 9114774
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
MH  - Breast Neoplasms/*diagnosis/*drug therapy
MH  - Contrast Media
MH  - Diffusion Magnetic Resonance Imaging/*methods
MH  - Female
MH  - *Gadolinium DTPA
MH  - Humans
MH  - Middle Aged
MH  - Neoadjuvant Therapy/methods
MH  - Prognosis
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Treatment Outcome
PMC - PMC3088808
EDAT- 2010/12/04 06:00
MHDA- 2011/09/14 06:00
CRDT- 2010/12/04 06:00
PHST- 2010/05/21 00:00 [received]
PHST- 2010/10/28 00:00 [accepted]
PHST- 2010/10/25 00:00 [revised]
PHST- 2010/12/04 06:00 [entrez]
PHST- 2010/12/04 06:00 [pubmed]
PHST- 2011/09/14 06:00 [medline]
AID - 10.1007/s00330-010-2020-3 [doi]
PST - ppublish
SO  - Eur Radiol. 2011 Jun;21(6):1188-99. doi: 10.1007/s00330-010-2020-3. Epub 2010 Dec
      3.


PMID- 21127111
OWN - NLM
STAT- MEDLINE
DCOM- 20110406
LR  - 20191210
IS  - 1475-3901 (Electronic)
IS  - 1475-3898 (Linking)
VI  - 19
IP  - 6
DP  - 2010 Dec
TI  - Preventing ethics conflicts and improving healthcare quality through system
      redesign.
PG  - 526-30
LID - 10.1136/qshc.2009.038943 [doi]
AB  - BACKGROUND: Ethics and quality care are common drivers for healthcare
      organisations. Both are based on ethics principles that are the foundation for
      quality, and are synergistic with the Institute of Medicine's six quality aims.
      This paper describes the relationship between ethics principles and the goals of 
      improving quality, safety and value. It demonstrates how healthcare staff,
      quality improvement professionals and ethics committee members could apply a
      quality improvement framework to address and prevent ethics issues. DISCUSSION:
      Recurring ethics issues can have a detrimental impact on both the quality of
      patient care and the culture of a healthcare organisation. Clinical staff and
      ethics committee members traditionally respond to ethics issues using a reactive 
      approach. Despite nascent interest in a system-oriented preventive approach to
      ethics issues, there is limited practical advice for ethics committee members
      regarding how to specifically implement a system redesign strategy. Using an
      illustrative case study, the authors demonstrate how to apply a recognised
      quality improvement framework, which focuses on clinical microsystems, to manage 
      and decrease ethics issues--therefore enhancing the organisation's quality of
      care. CONCLUSION: An important step in enhancing quality and ethics aims would be
      for the organisation's staff, including quality improvement professionals and
      ethics committee members, to collaborate in fostering system redesign. The
      authors' aim is not to examine in detail a specific quality improvement approach 
      or method; rather, they wish to highlight the synergy they believe exists between
      quality improvement efforts and organisational ethics issues.
FAU - Nelson, William A
AU  - Nelson WA
AD  - Center for Leadership and Improvement, The Dartmouth Institute for Health Policy 
      and Clinical Practice, Dartmouth Medical School, Lebanon, Hew Hampshire 03766,
      USA. william.a.nelson@dartmouth.edu
FAU - Gardent, Paul B
AU  - Gardent PB
FAU - Shulman, Eliza
AU  - Shulman E
FAU - Splaine, Mark E
AU  - Splaine ME
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Qual Saf Health Care
JT  - Quality & safety in health care
JID - 101136980
CIN - Qual Saf Health Care. 2010 Dec;19(6):473-4. PMID: 21127106
MH  - *Conflict, Psychological
MH  - Humans
MH  - Organizational Innovation
MH  - Primary Health Care/*ethics/*organization & administration
MH  - *Quality Assurance, Health Care
MH  - Safety Management
MH  - United States
EDAT- 2010/12/04 06:00
MHDA- 2011/04/07 06:00
CRDT- 2010/12/04 06:00
PHST- 2010/12/04 06:00 [entrez]
PHST- 2010/12/04 06:00 [pubmed]
PHST- 2011/04/07 06:00 [medline]
AID - 19/6/526 [pii]
AID - 10.1136/qshc.2009.038943 [doi]
PST - ppublish
SO  - Qual Saf Health Care. 2010 Dec;19(6):526-30. doi: 10.1136/qshc.2009.038943.


PMID- 21126996
OWN - NLM
STAT- MEDLINE
DCOM- 20110107
LR  - 20101203
IS  - 1460-2156 (Electronic)
IS  - 0006-8950 (Linking)
VI  - 133
IP  - Pt 12
DP  - 2010 Dec
TI  - Predisposition to accelerated Alzheimer-related changes in the brains of human
      immunodeficiency virus negative opiate abusers.
PG  - 3685-98
LID - 10.1093/brain/awq263 [doi]
AB  - Cognitive impairment is a recognized effect of drug misuse, including the use of 
      opiates. The pathological basis for this is unknown but the temporal and frontal 
      cortices have been implicated. We have shown previously that deposits of
      hyperphosphorylated tau in drug user brains exceed those seen in age-matched
      controls. The present quantitative study of hyperphosphorylated tau and beta
      amyloid in drug user brains allows comparison with the related pathology in
      Alzheimer's disease. Brains were obtained from the Edinburgh Medical Research
      Council Brain Banks, comprising 39 human immunodeficiency virus negative drug
      users, five subjects with Alzheimer's disease and 37 age-matched, cognitively
      normal controls, all legally and ethically approved for research.
      Hyperphosphorylated tau positive (AT8, AT100) neuropil threads were significantly
      increased in the frontal and temporal cortex, and in the locus coeruleus, of drug
      users aged > 30 years (all P = 0.04). Under the age of 30 years, drug users
      showed a similar increase in neuropil threads compared with controls, but this
      reached significance only in the frontal cortex (P = 0.03). Immunopositivity for 
      both three- and four-repeat tau was present in drug user brains. There was a
      direct relationship between the numbers of neuropil threads and of
      neurofibrillary tangles: neurofibrillary tangles were sparse in brains that had
      neuropil thread counts below 200 cm(2). Hyperphosphorylated tau positive neuropil
      threads increased at a faster rate in drug users than in controls and the levels 
      of the phosphorylating enzyme, GSK-3, was raised in drug user brains. Beta
      amyloid (AB4, AB42 and 4G8) was raised in drug user brains (mainly as shadow
      plaques) but not significantly different from controls and there was no
      correlation between high beta amyloid and hyperphosphorylated tau in individual
      cases. Hyperphosphorylated tau levels correlated significantly (P = 0.038) with
      microglial activation in drug users but not in controls. The levels of
      hyperphosphorylated tau in drug users fell far short of those seen in Alzheimer's
      disease but overlapped with those in elderly controls. We conclude that drug
      users show early Alzheimer's disease-related brain pathology that may be the
      basis for cognitive impairment and that neuroinflammation is an early
      accompanying feature. This provides an opportunity to study the pathogenesis of
      tau pathology in the human brain.
FAU - Anthony, Iain C
AU  - Anthony IC
AD  - Neuropathology and Forensic Medicine Units, Department of General Practice,
      University of Edinburgh, Edinburgh, EH8 9AG, UK.
FAU - Norrby, Katherine E
AU  - Norrby KE
FAU - Dingwall, Tommy
AU  - Dingwall T
FAU - Carnie, Frances W
AU  - Carnie FW
FAU - Millar, Tracey
AU  - Millar T
FAU - Arango, Juan Carlos
AU  - Arango JC
FAU - Robertson, Roy
AU  - Robertson R
FAU - Bell, Jeanne E
AU  - Bell JE
LA  - eng
GR  - Chief Scientist Office/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Brain
JT  - Brain : a journal of neurology
JID - 0372537
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Apolipoproteins E)
RN  - 0 (tau Proteins)
RN  - EC 2.7.11.26 (Glycogen Synthase Kinase 3)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alzheimer Disease/genetics/*pathology
MH  - Amyloid beta-Peptides/biosynthesis/genetics
MH  - Apolipoproteins E/genetics
MH  - Blood-Brain Barrier/physiology
MH  - Blotting, Western
MH  - Brain/*pathology
MH  - Disease Progression
MH  - Encephalitis/pathology
MH  - Female
MH  - Genotype
MH  - Glycogen Synthase Kinase 3/metabolism
MH  - HIV Seronegativity
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Middle Aged
MH  - Neurites/pathology
MH  - Opioid-Related Disorders/*pathology
MH  - Phosphorylation
MH  - Young Adult
MH  - tau Proteins/metabolism
EDAT- 2010/12/04 06:00
MHDA- 2011/01/08 06:00
CRDT- 2010/12/04 06:00
PHST- 2010/12/04 06:00 [entrez]
PHST- 2010/12/04 06:00 [pubmed]
PHST- 2011/01/08 06:00 [medline]
AID - awq263 [pii]
AID - 10.1093/brain/awq263 [doi]
PST - ppublish
SO  - Brain. 2010 Dec;133(Pt 12):3685-98. doi: 10.1093/brain/awq263.


PMID- 21126965
OWN - NLM
STAT- MEDLINE
DCOM- 20110523
LR  - 20151119
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 4
DP  - 2011 Apr
TI  - Changing attitudes towards euthanasia among medical students in Austria.
PG  - 227-9
LID - 10.1136/jme.2010.039792 [doi]
AB  - BACKGROUND: In most European countries the attitudes regarding the acceptability 
      of active euthanasia have clearly changed in the population since World War II.
      Therefore, it is interesting to know which trends in attitudes prevail among the 
      physicians of the future. METHODS: The present study analyses trends in the
      attitudes towards active euthanasia in medical students at the Medical University
      of Graz, Austria. The survey was conducted over a period of 9 years, enabling us 
      to investigate trends regarding both attitudes and underlying motives. RESULTS:
      Acceptance of active euthanasia increased from 16.3% to 29.1% to 49.5% in the
      periods from 2001 to 2003/04 to 2008/09. CONCLUSIONS: The survey period from 2001
      to 2009 reveals a massive change in medical students' attitudes towards active
      euthanasia under medical supervision. Ethical convictions of medical doctors seem
      to fall back behind a higher valuation of the autonomy of the patient.
FAU - Stronegger, Willibald J
AU  - Stronegger WJ
AD  - Institute of Social Medicine and Epidemiology, Medical University of Graz,
      Universitatsstrasse 6/I, A-8010 Graz, Austria. willibald.stronegger@medunigraz.at
FAU - Schmolzer, Christin
AU  - Schmolzer C
FAU - Rasky, Eva
AU  - Rasky E
FAU - Freidl, Wolfgang
AU  - Freidl W
LA  - eng
PT  - Journal Article
DEP - 20101201
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Attitude to Death
MH  - Austria
MH  - Euthanasia/ethics/*psychology/trends
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Male
MH  - Students, Medical/*psychology
MH  - Surveys and Questionnaires
MH  - Time Factors
EDAT- 2010/12/04 06:00
MHDA- 2011/05/24 06:00
CRDT- 2010/12/04 06:00
PHST- 2010/12/04 06:00 [entrez]
PHST- 2010/12/04 06:00 [pubmed]
PHST- 2011/05/24 06:00 [medline]
AID - jme.2010.039792 [pii]
AID - 10.1136/jme.2010.039792 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Apr;37(4):227-9. doi: 10.1136/jme.2010.039792. Epub 2010 Dec
      1.


PMID- 21126921
OWN - NLM
STAT- MEDLINE
DCOM- 20120131
LR  - 20111003
IS  - 1878-7533 (Electronic)
IS  - 1550-7289 (Linking)
VI  - 7
IP  - 5
DP  - 2011 Sep-Oct
TI  - Combined vaginal and abdominal approach to sleeve gastrectomy for morbid obesity 
      in women: a preliminary experience.
PG  - 581-6
LID - 10.1016/j.soard.2010.09.022 [doi]
AB  - BACKGROUND: Natural orifice translumenal endoscopic surgery is an emerging
      surgical phenomenon. Although the development of "pure" natural orifice
      translumenal endoscopic surgical techniques in humans has been slowed by major
      technical hurdles, "hybrid" or combined variants have been increasingly reported.
      Laparoscopic sleeve gastrectomy (SG) is a commonly performed treatment of morbid 
      obesity. We have developed a combined variant of SG for patients with morbid
      obesity. Our aim was to assess the feasibility and safety of such an approach,
      which could eventually reduce the postoperative pain, preserve the abdominal
      wall, and enhance cosmesis. METHODS: Combined, transvaginal and abdominal SG was 
      attempted in 20 patients. The inclusion criteria were morbid obesity (body mass
      index <50 kg/m(2)), female gender, an absence of gynecologic disorders, and the
      absence of major previous abdominal surgery. The local ethical committee approved
      the present study. The technique was performed using a vaginal incision with 1 or
      2 abdominal ports. RESULTS: The procedure was a success in 14 patients (70%). In 
      6 patients, conversion to a more conventional laparoscopic SG was required, with 
      >/= 1 abdominal ports added. The mean operative time was 116 minutes (range
      54-231). The postoperative complication rate was 5% (1 patient developed
      pneumonia). No hemorrhage, surgical site infection, or fistula was encountered.
      The mean length of hospital stay was 72 hours (range 24-144). CONCLUSION: Our
      combined, transvaginal and abdominal variant of laparoscopic SG was sure and
      feasible in a small series of selected patients with morbid obesity.
CI  - Copyright (c) 2011. Published by Elsevier Inc.
FAU - Chouillard, Elie K
AU  - Chouillard EK
AD  - Department of Minimally Invasive and Digestive Surgery, Poissy/Saint-Germain
      Mediacl Center, Poissy, France. elie.chouillard@psg.com
FAU - Al Khoury, Mansour
AU  - Al Khoury M
FAU - Bader, Georges
AU  - Bader G
FAU - Heitz, Denis
AU  - Heitz D
FAU - Elrassi, Ziad
AU  - Elrassi Z
FAU - Fauconnier, Arnaud
AU  - Fauconnier A
CN  - Intercontinental Society of Natural Orifice, Endoscopic, Laparoscopic Surgery
      (i-NOELS), Poissy, France
LA  - eng
PT  - Journal Article
DEP - 20101104
PL  - United States
TA  - Surg Obes Relat Dis
JT  - Surgery for obesity and related diseases : official journal of the American
      Society for Bariatric Surgery
JID - 101233161
SB  - IM
MH  - Adult
MH  - Feasibility Studies
MH  - Female
MH  - Gastrectomy/*methods
MH  - Humans
MH  - Length of Stay
MH  - Male
MH  - Middle Aged
MH  - Natural Orifice Endoscopic Surgery
MH  - Obesity, Morbid/surgery
MH  - Pain, Postoperative/prevention & control
MH  - Young Adult
EDAT- 2010/12/04 06:00
MHDA- 2012/02/01 06:00
CRDT- 2010/12/04 06:00
PHST- 2010/05/28 00:00 [received]
PHST- 2010/09/20 00:00 [revised]
PHST- 2010/09/25 00:00 [accepted]
PHST- 2010/12/04 06:00 [entrez]
PHST- 2010/12/04 06:00 [pubmed]
PHST- 2012/02/01 06:00 [medline]
AID - S1550-7289(10)00695-7 [pii]
AID - 10.1016/j.soard.2010.09.022 [doi]
PST - ppublish
SO  - Surg Obes Relat Dis. 2011 Sep-Oct;7(5):581-6. doi: 10.1016/j.soard.2010.09.022.
      Epub 2010 Nov 4.


PMID- 21126815
OWN - NLM
STAT- MEDLINE
DCOM- 20110316
LR  - 20211020
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 72
IP  - 1
DP  - 2011 Jan
TI  - Ironic technology: Old age and the implantable cardioverter defibrillator in US
      health care.
PG  - 6-14
LID - 10.1016/j.socscimed.2010.09.052 [doi]
AB  - We take the example of cardiac devices, specifically the implantable cardioverter
      defibrillator, or ICD, to explore the complex cultural role of technology in
      medicine today. We focus on persons age 80 and above, for whom ICD use is growing
      in the U.S. We highlight an ironic feature of this device. While it postpones
      death and 'saves' life by thwarting a lethal heart rhythm, it also prolongs
      living in a state of dying from heart failure. In that regard the ICD is
      simultaneously a technology of life extension and dying. We explore that irony
      among the oldest age group -- those whose considerations of medical interventions
      are framed by changing societal assumptions of what constitutes premature death, 
      the appropriate time for death and medicine's goals in an aging society.
      Background to the rapidly growing use of this device among the elderly is the
      'technological imperative' in medicine, bolstered today by the value given to
      evidence-based studies. We show how evidence contributes to standards of care and
      to the expansion of Medicare reimbursement criteria. Together, those factors
      shape the ethical necessity of physicians offering and patients accepting the ICD
      in late life. Two ethnographic examples document the ways in which those factors 
      are lived in treatment discussions and in expectations about death and longevity.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Kaufman, Sharon R
AU  - Kaufman SR
AD  - University of California, Institute for Health and Aging, San Francisco, CA
      94118, USA. sharon.kaufman@ucsf.edu
FAU - Mueller, Paul S
AU  - Mueller PS
FAU - Ottenberg, Abigale L
AU  - Ottenberg AL
FAU - Koenig, Barbara A
AU  - Koenig BA
LA  - eng
GR  - R01 AG028426/AG/NIA NIH HHS/United States
GR  - R01 AG028426-04/AG/NIA NIH HHS/United States
GR  - UL1 RR024150/RR/NCRR NIH HHS/United States
GR  - R01 AG28426/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20101111
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Aged, 80 and over
MH  - *Bioethical Issues
MH  - *Biomedical Enhancement/ethics
MH  - Choice Behavior
MH  - Cultural Characteristics
MH  - Defibrillators, Implantable/*statistics & numerical data
MH  - Delivery of Health Care
MH  - Evidence-Based Medicine
MH  - Heart Failure/mortality/*prevention & control
MH  - Humans
MH  - Longevity
MH  - Patient Participation
MH  - Physician-Patient Relations
MH  - Risk Assessment
MH  - United States
PMC - PMC3032945
MID - NIHMS252646
EDAT- 2010/12/04 06:00
MHDA- 2011/03/17 06:00
CRDT- 2010/12/04 06:00
PHST- 2010/04/15 00:00 [received]
PHST- 2010/09/23 00:00 [revised]
PHST- 2010/09/28 00:00 [accepted]
PHST- 2010/12/04 06:00 [entrez]
PHST- 2010/12/04 06:00 [pubmed]
PHST- 2011/03/17 06:00 [medline]
AID - S0277-9536(10)00766-5 [pii]
AID - 10.1016/j.socscimed.2010.09.052 [doi]
PST - ppublish
SO  - Soc Sci Med. 2011 Jan;72(1):6-14. doi: 10.1016/j.socscimed.2010.09.052. Epub 2010
      Nov 11.


PMID- 21126677
OWN - NLM
STAT- MEDLINE
DCOM- 20110323
LR  - 20161020
IS  - 1532-8473 (Electronic)
IS  - 1089-9472 (Linking)
VI  - 25
IP  - 6
DP  - 2010 Dec
TI  - Ethical and legal aspects, Part 3: secondary sources and references.
PG  - 421-4
LID - 10.1016/j.jopan.2010.09.003 [doi]
FAU - Moos, Daniel D
AU  - Moos DD
AD  - Kearney Anesthesia Associates, PC, Kearney, NE, USA. moosd@charter.net
FAU - Prior, Shari M
AU  - Prior SM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Perianesth Nurs
JT  - Journal of perianesthesia nursing : official journal of the American Society of
      PeriAnesthesia Nurses
JID - 9610507
MH  - *Ethics
MH  - *Jurisprudence
EDAT- 2010/12/04 06:00
MHDA- 2011/03/24 06:00
CRDT- 2010/12/04 06:00
PHST- 2010/08/05 00:00 [received]
PHST- 2010/09/14 00:00 [accepted]
PHST- 2010/12/04 06:00 [entrez]
PHST- 2010/12/04 06:00 [pubmed]
PHST- 2011/03/24 06:00 [medline]
AID - S1089-9472(10)00381-3 [pii]
AID - 10.1016/j.jopan.2010.09.003 [doi]
PST - ppublish
SO  - J Perianesth Nurs. 2010 Dec;25(6):421-4. doi: 10.1016/j.jopan.2010.09.003.


PMID- 21126115
OWN - NLM
STAT- MEDLINE
DCOM- 20110330
LR  - 20101203
IS  - 1364-6893 (Electronic)
IS  - 0144-3615 (Linking)
VI  - 30
IP  - 8
DP  - 2010
TI  - Curriculum evaluation from the trainees' perspective: application to the ALWP
      ATSM.
PG  - 795-9
LID - 10.3109/01443615.2010.514623 [doi]
AB  - Curriculum evaluation is a way to assess the quality of a curriculum or an
      educational intervention. The Advanced Labour Ward Practice (ALWP) ATSM (Advanced
      Training Skills Module) is the module that most advanced trainees pursue in their
      final years of training. Competencies gained in the module equip trainees to
      function as future consultants providing 24-h presence on the delivery suite.
      Evaluation is a four stage process: planning, data collection, analysing
      information and reporting the results. In this paper, we propose ways to evaluate
      this educational intervention (the ATSM itself), using two well established
      models in medical education: the RUFDATA principles relate to framing of
      decisions and the Kirkpatrick model deals with programme evaluation at four
      levels: reaction, learning, behaviour and results. The barriers to successful
      evaluation and the ways to overcome them have been discussed. On an ethical
      perspective, we ask whether one would be content with surrogate measures of
      better clinical outcome in the highest level of evaluation. Curriculum evaluation
      helps in programme expansion, modification and validation.
FAU - Mukhopadhyay, S
AU  - Mukhopadhyay S
AD  - Department of Obstetrics and Gynaecology, Chesterfield Royal Hospital NHS
      Foundation Trust, UK. drsujitmuk@yahoo.co.in
FAU - Smith, S
AU  - Smith S
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Obstet Gynaecol
JT  - Journal of obstetrics and gynaecology : the journal of the Institute of
      Obstetrics and Gynaecology
JID - 8309140
SB  - IM
MH  - Curriculum
MH  - *Evaluation Studies as Topic
MH  - Models, Theoretical
MH  - Obstetrics/*education
EDAT- 2010/12/04 06:00
MHDA- 2011/03/31 06:00
CRDT- 2010/12/04 06:00
PHST- 2010/12/04 06:00 [entrez]
PHST- 2010/12/04 06:00 [pubmed]
PHST- 2011/03/31 06:00 [medline]
AID - 10.3109/01443615.2010.514623 [doi]
PST - ppublish
SO  - J Obstet Gynaecol. 2010;30(8):795-9. doi: 10.3109/01443615.2010.514623.


PMID- 21125534
OWN - NLM
STAT- MEDLINE
DCOM- 20110128
LR  - 20101202
IS  - 1661-8157 (Print)
IS  - 1661-8157 (Linking)
VI  - 99
IP  - 24
DP  - 2010 Dec 1
TI  - [Placebo interventions in medical practice].
PG  - 1495-501
LID - 10.1024/1661-8157/a000322 [doi]
AB  - Surveys of physicians showed that they use placebo interventions with different
      intentions in practice. The ongoing debate whether this is ethically acceptable
      requires to engage in this topic. More and more results from research have shown 
      that placebo or contextual effects can be clinically relevant. It is worthwhile
      to think about the utilization of these effects for patients. For that purpose
      there are no ready-made solutions. Every physician has to decide for his or her
      own self whether and which therapy with doubtful specific efficacy he or she
      uses. This article may assist physicians to deal with this topic and to find an
      own well-grounded position.
FAU - Fassler, M
AU  - Fassler M
AD  - Institut fur Biomedizinische Ethik, Universitat Zurich. faessler@ethik.uzh.ch
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Placebointerventionen in der medizinischen Praxis.
PL  - Switzerland
TA  - Praxis (Bern 1994)
JT  - Praxis
JID - 101468093
RN  - 0 (Placebos)
SB  - IM
MH  - *Ethics, Medical
MH  - Humans
MH  - Physician-Patient Relations/ethics
MH  - Placebo Effect
MH  - Placebos/*therapeutic use
MH  - Psychophysiologic Disorders/drug therapy/psychology
MH  - Randomized Controlled Trials as Topic/ethics
MH  - Social Facilitation
MH  - Switzerland
MH  - Treatment Outcome
MH  - Trust
EDAT- 2010/12/03 06:00
MHDA- 2011/02/01 06:00
CRDT- 2010/12/03 06:00
PHST- 2010/12/03 06:00 [entrez]
PHST- 2010/12/03 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
AID - 10.1024/1661-8157/a000322 [doi]
PST - ppublish
SO  - Praxis (Bern 1994). 2010 Dec 1;99(24):1495-501. doi: 10.1024/1661-8157/a000322.


PMID- 21125373
OWN - NLM
STAT- MEDLINE
DCOM- 20110429
LR  - 20110818
IS  - 1435-1269 (Electronic)
IS  - 0948-6704 (Linking)
VI  - 43
IP  - 6
DP  - 2010 Dec
TI  - [The wisdom of the elderly].
PG  - 393-8
LID - 10.1007/s00391-010-0119-4 [doi]
AB  - Old age is nowadays defined as very old and people are characterized by illness, 
      degeneration and health costs. Ethics in this case have to be healthcare ethics, 
      which accept the challenge to lead people in old age through the healthcare point
      of view and demonstrate how to integrate their wisdom into culture and society.
FAU - Schnell, M W
AU  - Schnell MW
AD  - Institut fur Ethik und Kommunikation im Gesundheitswesen (IEKG), Private
      Universitat Witten/Herdecke gGmbH, Alfred-Herrhausen-Str. 50, 58448, Witten,
      Germany. Schnell@uni-wh.de
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Weisheit des alten Menschen.
DEP - 20101202
PL  - Germany
TA  - Z Gerontol Geriatr
JT  - Zeitschrift fur Gerontologie und Geriatrie
JID - 9506215
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*ethics
MH  - Chronic Disease/psychology
MH  - *Ethics, Medical
MH  - Female
MH  - Germany
MH  - Humans
MH  - *Intelligence
MH  - Intergenerational Relations
MH  - Male
MH  - *Personhood
MH  - Physician-Patient Relations/ethics
MH  - Self Concept
MH  - Social Desirability
MH  - Social Justice/ethics
MH  - Social Security/ethics
MH  - *Social Values
EDAT- 2010/12/03 06:00
MHDA- 2011/04/30 06:00
CRDT- 2010/12/03 06:00
PHST- 2010/01/27 00:00 [received]
PHST- 2010/04/30 00:00 [accepted]
PHST- 2010/12/03 06:00 [entrez]
PHST- 2010/12/03 06:00 [pubmed]
PHST- 2011/04/30 06:00 [medline]
AID - 10.1007/s00391-010-0119-4 [doi]
PST - ppublish
SO  - Z Gerontol Geriatr. 2010 Dec;43(6):393-8. doi: 10.1007/s00391-010-0119-4. Epub
      2010 Dec 2.


PMID- 21125312
OWN - NLM
STAT- MEDLINE
DCOM- 20110613
LR  - 20211020
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 22
IP  - 4
DP  - 2010 Dec
TI  - Assessing physicians' roles on health care ethics committees.
PG  - 275-86
LID - 10.1007/s10730-010-9142-5 [doi]
AB  - The purpose of this study was to examine the role of physicians on HEC including 
      structural and process features. Four committees were selected from among 12
      volunteering to participate with 12 sessions observed. Power analysis (0.8)
      confirmed an adequate number of communication exchanges, and no statistical
      significant difference (p < 0.05) among two prior surveys affirmed the sample.
      Data collection included established questionnaires and communication analyses
      with a tested method. Results revealed physician presence was robust and similar 
      to prior reports on HEC structure; however, physicians rated their role
      effectiveness lower than other occupations and lower than overall committee
      effectiveness. Communication exchanges representing process revealed three
      positive communication types, and consistent attempts to aid committee functions 
      through consensual processes that also were substantiated by non-physician
      members. Findings suggested more attention to both structural and process
      functions of HEC and their members.
FAU - McDaniel, Charlotte
AU  - McDaniel C
AD  - The Center for Law and Religion, Emory University, Atlanta, GA 30322, USA.
      charlotte.mcdaniel@gmail.com
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - *Delivery of Health Care
MH  - *Ethics Committees
MH  - Humans
MH  - *Physician's Role
MH  - Surveys and Questionnaires
MH  - United States
EDAT- 2010/12/03 06:00
MHDA- 2011/06/15 06:00
CRDT- 2010/12/03 06:00
PHST- 2010/12/03 06:00 [entrez]
PHST- 2010/12/03 06:00 [pubmed]
PHST- 2011/06/15 06:00 [medline]
AID - 10.1007/s10730-010-9142-5 [doi]
PST - ppublish
SO  - HEC Forum. 2010 Dec;22(4):275-86. doi: 10.1007/s10730-010-9142-5.


PMID- 21125157
OWN - NLM
STAT- MEDLINE
DCOM- 20110616
LR  - 20131121
IS  - 1809-4570 (Electronic)
IS  - 0482-5004 (Linking)
VI  - 50
IP  - 3
DP  - 2010 May-Jun
TI  - Ethical aspects of medical publications: clinical assays on biological agents.
PG  - 217-20
LID - S0482-50042010000300001 [pii]
FAU - Samara, Adil Muhib
AU  - Samara AM
LA  - eng
LA  - por
PT  - Editorial
PL  - Brazil
TA  - Rev Bras Reumatol
JT  - Revista brasileira de reumatologia
JID - 0404256
RN  - 0 (Biological Products)
SB  - IM
MH  - *Biological Products/therapeutic use
MH  - *Clinical Trials as Topic
MH  - Publishing/*ethics
EDAT- 2010/12/03 06:00
MHDA- 2011/06/17 06:00
CRDT- 2010/12/03 06:00
PHST- 2010/12/03 06:00 [entrez]
PHST- 2010/12/03 06:00 [pubmed]
PHST- 2011/06/17 06:00 [medline]
AID - S0482-50042010000300001 [pii]
PST - ppublish
SO  - Rev Bras Reumatol. 2010 May-Jun;50(3):217-20.


PMID- 21123688
OWN - NLM
STAT- MEDLINE
DCOM- 20110406
LR  - 20211020
IS  - 1931-7913 (Electronic)
IS  - 1931-7913 (Linking)
VI  - 9
IP  - 4
DP  - 2010 Winter
TI  - Using critical literacy to explore genetics and its ethical, legal, and social
      issues with in-service secondary teachers.
PG  - 422-30
LID - 10.1187/cbe.09-09-0065 [doi]
AB  - The described interdisciplinary course helped a mixed population of in-service
      secondary English and biology teacher-participants increase their genetics
      content knowledge and awareness of Ethical, Legal, and Social Implications (ELSI)
      that arose from discoveries and practices associated with the Human Genome
      Project. This was accomplished by applying a critical literacy approach that
      allows people develop cognitive skills such that they are able to "read the
      world" (Wink, 2004). The approach is one that permits readers to go beyond the
      literal text to examine what is present as well as what is missing as it relates 
      to issues of equity and fairness. Becoming critically literate enabled these
      teacher-participants to challenge the subtle attitudes, values, and beliefs
      conveyed by a range of written and oral texts. The teacher-participants in this
      course improved their critical literacy skills by actively reading, critically
      writing about, and using evidence to support their conclusions about issues
      arising from advances in human genetics. A biologist, a linguist, and an educator
      collaboratively designed and taught the course. The personalized focus on the
      integration of thoughtful reading and writing in this class enhanced the
      teacher-participants' (n = 16) professional and intellectual development and will
      potentially improve learning in their biology and English classrooms in the
      future.
FAU - Gleason, Michael L
AU  - Gleason ML
AD  - Departments of Biological and Environmental Sciences, Georgia College & State
      University, Milledgeville, 31061, USA. mike.gleason@gcsu.edu
FAU - Melancon, Megan E
AU  - Melancon ME
FAU - Kleine, Karynne L M
AU  - Kleine KL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - CBE Life Sci Educ
JT  - CBE life sciences education
JID - 101269039
SB  - IM
MH  - Genomics/*education/ethics/legislation & jurisprudence
MH  - Human Genome Project
MH  - Humans
MH  - Linguistics
MH  - Social Change
MH  - Teaching/*methods
PMC - PMC2995759
EDAT- 2010/12/03 06:00
MHDA- 2011/04/07 06:00
CRDT- 2010/12/03 06:00
PHST- 2010/12/03 06:00 [entrez]
PHST- 2010/12/03 06:00 [pubmed]
PHST- 2011/04/07 06:00 [medline]
AID - 9/4/422 [pii]
AID - 10.1187/cbe.09-09-0065 [doi]
PST - ppublish
SO  - CBE Life Sci Educ. 2010 Winter;9(4):422-30. doi: 10.1187/cbe.09-09-0065.


PMID- 21123514
OWN - NLM
STAT- MEDLINE
DCOM- 20110419
LR  - 20161020
IS  - 1526-3347 (Electronic)
IS  - 0191-9601 (Linking)
VI  - 31
IP  - 12
DP  - 2010 Dec
TI  - Children who have special health-care needs: ethical issues.
PG  - 514-7
LID - 10.1542/pir.31-12-514 [doi]
FAU - Okun, Alex
AU  - Okun A
AD  - Division of General Pediatrics, Department of Pediatrics, Albert Einstein College
      of Medicine/Children's Hospital at Montefiore, Bronx, NY, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Pediatr Rev
JT  - Pediatrics in review
JID - 8103046
SB  - IM
MH  - Child
MH  - Health Services Needs and Demand/*ethics
MH  - Humans
MH  - Pediatrics/*ethics
EDAT- 2010/12/03 06:00
MHDA- 2011/04/20 06:00
CRDT- 2010/12/03 06:00
PHST- 2010/12/03 06:00 [entrez]
PHST- 2010/12/03 06:00 [pubmed]
PHST- 2011/04/20 06:00 [medline]
AID - 31/12/514 [pii]
AID - 10.1542/pir.31-12-514 [doi]
PST - ppublish
SO  - Pediatr Rev. 2010 Dec;31(12):514-7. doi: 10.1542/pir.31-12-514.


PMID- 21123495
OWN - NLM
STAT- MEDLINE
DCOM- 20101228
LR  - 20101202
IS  - 1930-7837 (Electronic)
IS  - 0022-0337 (Linking)
VI  - 74
IP  - 12
DP  - 2010 Dec
TI  - The role of empathy in ethics.
PG  - 1275-7; author reply 1278-81
FAU - Chambers, David W
AU  - Chambers DW
LA  - eng
PT  - Comment
PT  - Letter
PL  - United States
TA  - J Dent Educ
JT  - Journal of dental education
JID - 8000150
SB  - IM
CON - J Dent Educ. 2010 Jun;74(6):567-78. PMID: 20516296
MH  - Altruism
MH  - Biological Evolution
MH  - Cooperative Behavior
MH  - *Empathy
MH  - *Ethics, Dental
MH  - Humans
MH  - Moral Obligations
EDAT- 2010/12/03 06:00
MHDA- 2010/12/29 06:00
CRDT- 2010/12/03 06:00
PHST- 2010/12/03 06:00 [entrez]
PHST- 2010/12/03 06:00 [pubmed]
PHST- 2010/12/29 06:00 [medline]
AID - 74/12/1275 [pii]
PST - ppublish
SO  - J Dent Educ. 2010 Dec;74(12):1275-7; author reply 1278-81.


PMID- 21123303
OWN - NLM
STAT- MEDLINE
DCOM- 20110429
LR  - 20211020
IS  - 1758-1117 (Electronic)
IS  - 0023-6772 (Linking)
VI  - 45
IP  - 1
DP  - 2011 Jan
TI  - A guide to defining and implementing protocols for the welfare assessment of
      laboratory animals: eleventh report of the BVAAWF/FRAME/RSPCA/UFAW Joint Working 
      Group on Refinement.
PG  - 1-13
LID - 10.1258/la.2010.010031 [doi]
AB  - The refinement of husbandry and procedures to reduce animal suffering and improve
      welfare is an essential component of humane science. Successful refinement
      depends upon the ability to assess animal welfare effectively, and detect any
      signs of pain or distress as rapidly as possible, so that any suffering can be
      alleviated. This document provides practical guidance on setting up and operating
      effective protocols for the welfare assessment of animals used in research and
      testing. It sets out general principles for more objective observation of
      animals, recognizing and assessing indicators of pain or distress and tailoring
      these to individual projects. Systems for recording indicators, including score
      sheets, are reviewed and guidance is set out on determining practical monitoring 
      regimes that are more likely to detect any signs of suffering. This guidance is
      intended for all staff required to assess or monitor animal welfare, including
      animal technologists and care staff, veterinarians and scientists. It will also
      be of use to members of ethics or animal care and use committees. A longer
      version of this document, with further background information and extra topics
      including training and information sharing, is available on the Laboratory
      Animals website.
FAU - Hawkins, P
AU  - Hawkins P
AD  - Research Animals Department, RSPCA, Wilberforce Way, Southwater, West Sussex RH13
      9RS, UK.
FAU - Morton, D B
AU  - Morton DB
FAU - Burman, O
AU  - Burman O
FAU - Dennison, N
AU  - Dennison N
FAU - Honess, P
AU  - Honess P
FAU - Jennings, M
AU  - Jennings M
FAU - Lane, S
AU  - Lane S
FAU - Middleton, V
AU  - Middleton V
FAU - Roughan, J V
AU  - Roughan JV
FAU - Wells, S
AU  - Wells S
FAU - Westwood, K
AU  - Westwood K
CN  - UK Joint Working Group on Refinement BVAAWF/FRAME/RSPCA/UFAW
LA  - eng
GR  - BB/F015631/1/BB_/Biotechnology and Biological Sciences Research Council/United
      Kingdom
GR  - G0400227/1/NC3RS_/National Centre for the Replacement, Refinement and Reduction
      of Animals in Research/United Kingdom
GR  - MC_UP_1502/1/MRC_/Medical Research Council/United Kingdom
PT  - Guideline
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101201
PL  - England
TA  - Lab Anim
JT  - Laboratory animals
JID - 0112725
SB  - IM
MH  - Animal Husbandry/*methods/*standards
MH  - Animal Welfare/*standards
MH  - Animals
MH  - Animals, Laboratory
MH  - Laboratory Animal Science/*standards
EDAT- 2010/12/03 06:00
MHDA- 2011/04/30 06:00
CRDT- 2010/12/03 06:00
PHST- 2010/12/03 06:00 [entrez]
PHST- 2010/12/03 06:00 [pubmed]
PHST- 2011/04/30 06:00 [medline]
AID - la.2010.010031 [pii]
AID - 10.1258/la.2010.010031 [doi]
PST - ppublish
SO  - Lab Anim. 2011 Jan;45(1):1-13. doi: 10.1258/la.2010.010031. Epub 2010 Dec 1.


PMID- 21123087
OWN - NLM
STAT- MEDLINE
DCOM- 20110616
LR  - 20191210
IS  - 1552-6917 (Electronic)
IS  - 1055-3290 (Linking)
VI  - 22
IP  - 2
DP  - 2011 Mar-Apr
TI  - The impact of an education intervention to change nurses' HIV-related knowledge
      and attitudes in Lithuania: a randomized controlled trial.
PG  - 140-9
LID - 10.1016/j.jana.2010.07.006 [doi]
AB  - The purpose of this study was to describe the effect of an intervention program
      on nurses' HIV-related knowledge and attitudes in Lithuania. The program focused 
      on HIV epidemiology, transmission, coinfections, treatment and care, risk
      contacts, and moral and ethical dilemmas. It was designed to increase nurses'
      knowledge and positive attitudes concerning HIV. The study used a randomized
      controlled trial design with two experimental groups ([EG]; EG1, n = 63, EG2, n= 
      63) and one control group (n= 59) in three Lithuanian hospitals. Data were
      collected using a questionnaire developed by Held (1993). The questionnaire
      included questions about participant demographic characteristics, knowledge, and 
      attitudes toward those living with HIV. The education intervention, which
      combined a 2-day workshop and written materials, had a positive effect on the
      knowledge levels of nurses. However, written materials alone failed to improve
      nurses' knowledge or change their attitudes.
CI  - Copyright (c) 2011 Association of Nurses in AIDS Care. Published by Elsevier Inc.
      All rights reserved.
FAU - Mockiene, Vida
AU  - Mockiene V
AD  - Department of Nursing Science, University of Tampere, Tampere, Finland.
FAU - Suominen, Tarja
AU  - Suominen T
FAU - Valimaki, Maritta
AU  - Valimaki M
FAU - Razbadauskas, Arturas
AU  - Razbadauskas A
FAU - Martinkenas, Arvydas
AU  - Martinkenas A
FAU - Caplinskas, Saulius
AU  - Caplinskas S
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20101130
PL  - United States
TA  - J Assoc Nurses AIDS Care
JT  - The Journal of the Association of Nurses in AIDS Care : JANAC
JID - 9111870
SB  - IM
MH  - *Attitude of Health Personnel
MH  - *Education, Nursing, Continuing
MH  - HIV Infections/*nursing
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Lithuania
MH  - Nurses/*psychology
MH  - Outcome Assessment, Health Care
EDAT- 2010/12/03 06:00
MHDA- 2011/06/17 06:00
CRDT- 2010/12/03 06:00
PHST- 2009/12/10 00:00 [received]
PHST- 2010/07/24 00:00 [accepted]
PHST- 2010/12/03 06:00 [entrez]
PHST- 2010/12/03 06:00 [pubmed]
PHST- 2011/06/17 06:00 [medline]
AID - S1055-3290(10)00119-6 [pii]
AID - 10.1016/j.jana.2010.07.006 [doi]
PST - ppublish
SO  - J Assoc Nurses AIDS Care. 2011 Mar-Apr;22(2):140-9. doi:
      10.1016/j.jana.2010.07.006. Epub 2010 Nov 30.


PMID- 21122917
OWN - NLM
STAT- MEDLINE
DCOM- 20110613
LR  - 20110207
IS  - 1873-6386 (Electronic)
IS  - 0160-2527 (Linking)
VI  - 34
IP  - 1
DP  - 2011 Jan-Feb
TI  - Mentally ill offenders in prison: the Belgian case.
PG  - 71-8
LID - 10.1016/j.ijlp.2010.11.011 [doi]
AB  - According to the EUPRIS-study on mental health in prisons (2007), available data 
      on mental disorders in prison are scarce. Therefore, this study aims at
      summarizing and discussing the available knowledge on incarcerated mentally ill
      offenders concerning: (1) the screening and assessment for detecting mental
      health; (2) the psychiatric expertise in order to evaluate the mental status; and
      (3) the development and provision of forensic psychiatric treatment and care.
      These findings will be applied to the current situation in Belgium, which is a
      particularly interesting case. Belgium is currently facing difficulties
      concerning a large population of interned mentally ill offenders residing in
      correctional establishments. Implications with regard to the penal code, general 
      or mental health legislation, screening, assessment, and treatment could deliver 
      interesting viewpoints on how this problem could be tackled more effectively.
      Therefore, the findings will be discussed with reference to the international
      scientific and policy debate, focusing on ethical implications.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Vandevelde, Stijn
AU  - Vandevelde S
AD  - University College Ghent, Faculty of Social Work and Welfare Studies, Belgium.
      Stijn.Vandevelde@hogent.be
FAU - Soyez, Veerle
AU  - Soyez V
FAU - Vander Beken, Tom
AU  - Vander Beken T
FAU - De Smet, Stefaan
AU  - De Smet S
FAU - Boers, Anja
AU  - Boers A
FAU - Broekaert, Eric
AU  - Broekaert E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101203
PL  - Netherlands
TA  - Int J Law Psychiatry
JT  - International journal of law and psychiatry
JID - 7806862
SB  - IM
MH  - Belgium
MH  - Female
MH  - Forensic Psychiatry
MH  - Humans
MH  - Male
MH  - Mass Screening
MH  - *Mental Disorders/diagnosis/therapy
MH  - Prisoners/*psychology
MH  - Professional Competence
MH  - Psychiatry/standards
EDAT- 2010/12/03 06:00
MHDA- 2011/06/15 06:00
CRDT- 2010/12/03 06:00
PHST- 2010/12/03 06:00 [entrez]
PHST- 2010/12/03 06:00 [pubmed]
PHST- 2011/06/15 06:00 [medline]
AID - S0160-2527(10)00124-X [pii]
AID - 10.1016/j.ijlp.2010.11.011 [doi]
PST - ppublish
SO  - Int J Law Psychiatry. 2011 Jan-Feb;34(1):71-8. doi: 10.1016/j.ijlp.2010.11.011.
      Epub 2010 Dec 3.


PMID- 21122465
OWN - NLM
STAT- MEDLINE
DCOM- 20110419
LR  - 20101202
IS  - 1603-9629 (Electronic)
IS  - 0907-8916 (Linking)
VI  - 57
IP  - 12
DP  - 2010 Dec
TI  - Abdominal aortic aneurysms.
PG  - B4219
AB  - Although the number of elective operations for abdominal aortic aneurysms (AAA)
      is increasing, the sex- and age-standardised mortality rate of AAAs continues to 
      rise, especially among men aged 65 years or more. The lethality of ruptured AAA
      continues to be 80-95%, compared with 5-7% by elective surgery of symptomfree
      AAA. In order to fulfil all WHO, European, and Danish criteria for screening, a
      randomised hospitalbased screening trial of 12,639 65-73 year old men in Viborg
      County (Denmark) was initiated in 1994. It seemed that US screening is a valid,
      suitable and acceptable method of screening. The acceptance rate was 77%, and 95%
      accept control scans. Furthermore, persons at the highest risk of having an AAA
      attend screening more frequently. We found that 97% of the interval cases
      developed from aortas that initially measured 2.5-2.9 cm - i.e. approx. only 5%
      attenders need re-screening at 5-year intervals. Two large RCTs have given clear 
      indications of operation. Survivors of surgery enjoy the same quality of life as 
      the background population, and only 2-5% of patients refuse an offer of surgery. 
      Early detection seems relevant since the cardiovascular mortality is more than 4 
      times higher in AAA patients without previous hospital discharge diagnoses due to
      cardiovascular disease than among similar men without AAA. The absolute risk
      difference after 5 years was 16%. So, they will benefit from general
      cardiovascular preventive action as smoking cessation, statins and low-dose
      aspirin, which could inhibit further AAA progression. All 4 existing RCTs point
      in the same direction, viz. in favour of screening of men aged 65 and above. We
      found that screening significantly reduced AAA-related mortality by 67% within
      the first five years (NNT = 352). Restriction of screening to men with previous
      cardiovascular or pulmonary hospital discharge diagnoses would request only 27%
      of the relevant male population study to be invited, but would only have
      prevented 46.7% of the AAA-related deaths. However, the benefit was similar, and 
      low risk screening reduced AAA specific mortality by 78% compared to 52% in the
      high risk group after 14 years. Despite attractive sustained benefit and improved
      cost effectiveness was reported by MASS trial after 10 years, cost effectiveness 
      continues to be discussed. We found after 14 years that screening had reduced
      AAA-specific mortality by 66% (NNT = 135). The cost per life year gained was 157 
      euro [1,170 DKK] and the cost per QALY at 178 euro [1,326 DKK]. In all, the
      ethical dilemma of the prophylactic operation, and the limited psychological side
      effects seem not to outweigh the benefits of screening. Conclusively, we found
      that offering men aged 65-73 years screening for AAA seems acceptable according
      to criteria from WHO, Council of Europe, and the Danish National Board of Health.
      In US, UK, and Sweden national programmes are implemented. In Denmark, a flawed
      HTA from the region of Mid Denmark based upon an economic model, which excluded
      large AAAs, emergency operations of unruptured cases, and costs for intensive
      care beyond 48 hours are blocking a qualified decision. Future topics for will be
      creation and validation of multivariate models predicting need for later repair. 
      We found AAA-size, wall calcification, smoking, tPA and antibodies against C.
      pneumoniae to be such candidates. Antibiotic treatment for chlamydial infection
      are disappointing, and we found no sign of C. pneumoniae in AAA walls but rather 
      signs of proteins cross-reacting with chlamydial antibodies indicating "molecular
      mimicry" as an autoimmune reaction, which calls for further attention. More
      precise methods for measuring the degree of wall calcification must be developed 
      and validated.
FAU - Lindholt, Jes Sanddal
AU  - Lindholt JS
AD  - Department of Vascular Surgery, Viborg Hospital, Denmark.
      jes.s.lindholt@viborg.rm.dk
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Denmark
TA  - Dan Med Bull
JT  - Danish medical bulletin
JID - 0066040
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Aortic Aneurysm, Abdominal/*diagnosis/epidemiology/*therapy
MH  - Child
MH  - Denmark/epidemiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Mass Screening
MH  - Middle Aged
MH  - Prognosis
MH  - Risk Assessment
MH  - Vascular Surgical Procedures
EDAT- 2010/12/03 06:00
MHDA- 2011/04/20 06:00
CRDT- 2010/12/03 06:00
PHST- 2010/12/03 06:00 [entrez]
PHST- 2010/12/03 06:00 [pubmed]
PHST- 2011/04/20 06:00 [medline]
AID - B4219 [pii]
PST - ppublish
SO  - Dan Med Bull. 2010 Dec;57(12):B4219.


PMID- 21122094
OWN - NLM
STAT- MEDLINE
DCOM- 20110418
LR  - 20220129
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 11
DP  - 2010 Dec 1
TI  - Participants' preference for type of leaflet used to feed back the results of a
      randomised trial: a survey.
PG  - 116
LID - 10.1186/1745-6215-11-116 [doi]
AB  - BACKGROUND: Hundreds of thousands of volunteers take part in medical research,
      but many will never hear from researchers about what the study revealed. There is
      a growing demand for the results of randomised trials to be fed back to research 
      participants both for ethical research practice and for ensuring their
      co-operation in a trial. This study aims to determine participants' preferences
      for type of leaflet (short versus long) used to summarise the findings of a
      randomised trial; and to test whether certain characteristics explained
      participants' preferences. METHODS: 553 participants in a randomised trial about 
      General Practitioners' access to Magnetic Resonance Imaging for patients
      presenting with suspected internal derangement of the knee were asked in the
      final follow-up questionnaire whether they would like to be fed back the results 
      of the trial. Participants who agreed to this were included in a postal
      questionnaire survey asking about their preference, if any, between a short and a
      long leaflet and what it was about the leaflet that they preferred. Multinomial
      logistic regression was used to test whether certain demographics of responding
      participants along with treatment group explained whether a participant had a
      preference for type of leaflet or no preference. RESULTS: Of the participants who
      returned the final follow-up questionnaire, 416 (88%) agreed to receive the
      results of the trial. Subsequently 132 (32%) participants responded to the
      survey. Most participants preferred the longer leaflet (55%) and the main reasons
      for this were the use of technical information (94%) and diagrams (89%). There
      was weak evidence to suggest that gender might explain whether participants have 
      a preference for type of leaflet or not (P = 0.084). CONCLUSIONS: Trial
      participants want to receive feed back about the results and appear to prefer a
      longer leaflet. Males and females might require information to be communicated to
      them differently and should be the focus of further research. TRIAL REGISTRATION:
      The trial is registered with http://www.isrctn.org/ and ID is ISRCTN76616358.
FAU - Brealey, Stephen
AU  - Brealey S
AD  - Department of Health Sciences, Seebohm Rowntree Building, University of York,
      Heslington, York YO10 5DD, UK. stephen.brealey@york.ac.uk
FAU - Andronis, Lazaros
AU  - Andronis L
FAU - Dennis, Laura
AU  - Dennis L
FAU - Atwell, Christine
AU  - Atwell C
FAU - Bryan, Stirling
AU  - Bryan S
FAU - Coulton, Simon
AU  - Coulton S
FAU - Cox, Helen
AU  - Cox H
FAU - Cross, Ben
AU  - Cross B
FAU - Fylan, Fiona
AU  - Fylan F
FAU - Garratt, Andrew
AU  - Garratt A
FAU - Gilbert, Fiona
AU  - Gilbert F
FAU - Gillan, Maureen
AU  - Gillan M
FAU - Hendry, Maggie
AU  - Hendry M
FAU - Hood, Kerenza
AU  - Hood K
FAU - Houston, Helen
AU  - Houston H
FAU - King, David
AU  - King D
FAU - Morton, Veronica
AU  - Morton V
FAU - Robling, Michael
AU  - Robling M
FAU - Russell, Ian
AU  - Russell I
FAU - Wilkinson, Clare
AU  - Wilkinson C
LA  - eng
SI  - ISRCTN/ISRCTN76616358
GR  - G0001133/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20101201
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
SB  - IM
MH  - Adult
MH  - *Feedback
MH  - Female
MH  - Humans
MH  - *Information Dissemination
MH  - Likelihood Functions
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - *Patient Preference
MH  - Surveys and Questionnaires
PMC - PMC3002349
EDAT- 2010/12/03 06:00
MHDA- 2011/04/19 06:00
CRDT- 2010/12/03 06:00
PHST- 2010/04/29 00:00 [received]
PHST- 2010/12/01 00:00 [accepted]
PHST- 2010/12/03 06:00 [entrez]
PHST- 2010/12/03 06:00 [pubmed]
PHST- 2011/04/19 06:00 [medline]
AID - 1745-6215-11-116 [pii]
AID - 10.1186/1745-6215-11-116 [doi]
PST - epublish
SO  - Trials. 2010 Dec 1;11:116. doi: 10.1186/1745-6215-11-116.


PMID- 21121714
OWN - NLM
STAT- MEDLINE
DCOM- 20110906
LR  - 20110503
IS  - 1476-4954 (Electronic)
IS  - 1476-4954 (Linking)
VI  - 24
IP  - 6
DP  - 2011 Jun
TI  - Ethical charter of Union of European Neonatal and Perinatal Societies.
PG  - 855-8
LID - 10.3109/14767058.2010.531314 [doi]
AB  - The Union of European Neonatal and Perinatal Societies, worried for the lack of
      unanimous guidelines in the ethical domain, propose a 10-point charter about the 
      ethical rights of the newborns. It is complementary to other charters, such as
      the United Nations charter of children's rights, but it adds some specific and
      debated points, to find a common denominator, hopefully useful to the ongoing
      debate.
FAU - Guimaraes, Hercilia
AU  - Guimaraes H
AD  - Neonatal Intensive Care Unit, Sao Joao Hospital, University of Porto, Portugal.
FAU - Sanchez-Luna, Manuel
AU  - Sanchez-Luna M
FAU - Bellieni, Carlo Valerio
AU  - Bellieni CV
FAU - Buonocore, Giuseppe
AU  - Buonocore G
CN  - Union of European Neonatal and Perinatal Societies
LA  - eng
PT  - Journal Article
PT  - Practice Guideline
DEP - 20101201
PL  - England
TA  - J Matern Fetal Neonatal Med
JT  - The journal of maternal-fetal & neonatal medicine : the official journal of the
      European Association of Perinatal Medicine, the Federation of Asia and Oceania
      Perinatal Societies, the International Society of Perinatal Obstetricians
JID - 101136916
RN  - 0 (Placebos)
SB  - IM
MH  - Caregivers/psychology
MH  - *Ethics, Medical
MH  - Europe
MH  - Humans
MH  - Infant, Newborn
MH  - Neonatology/*ethics/organization & administration
MH  - Pain/congenital/diagnosis
MH  - Patient Rights
MH  - Perinatology/*ethics/organization & administration
MH  - Placebos
MH  - Social Support
MH  - *Societies, Medical/ethics/organization & administration
EDAT- 2010/12/03 06:00
MHDA- 2011/09/07 06:00
CRDT- 2010/12/03 06:00
PHST- 2010/12/03 06:00 [entrez]
PHST- 2010/12/03 06:00 [pubmed]
PHST- 2011/09/07 06:00 [medline]
AID - 10.3109/14767058.2010.531314 [doi]
PST - ppublish
SO  - J Matern Fetal Neonatal Med. 2011 Jun;24(6):855-8. doi:
      10.3109/14767058.2010.531314. Epub 2010 Dec 1.


PMID- 21120631
OWN - NLM
STAT- MEDLINE
DCOM- 20120221
LR  - 20211020
IS  - 1574-4647 (Electronic)
IS  - 0161-9152 (Linking)
VI  - 33
IP  - 4
DP  - 2011 Dec
TI  - Influence of two methods of dietary restriction on life history features and
      aging of the cricket Acheta domesticus.
PG  - 509-22
LID - 10.1007/s11357-010-9195-z [doi]
AB  - Studying aging is constrained using vertebrates by their longevity, size, ethical
      restrictions, and expense. The key insect model, Drosophila melanogaster, is
      holometabolous. Larvae feed on yeast in moist media and adults sponge food. Most 
      aging studies are restricted to adults. Another key model, the nematode
      Caenorhabditis elegans, feeds on bacteria in moist media. For either invertebrate
      refreshing test materials, preventing degradation and obtaining accurate dosing
      are difficult even with synthetic media. The cricket Acheta domesticus has a
      short lifespan ( approximately 120 days at 30 degrees C) and is omnivorous.
      Age-matched cohorts are easily obtained from eggs. The life cycle is
      hemimetabolous and nymphs eat the same foods as adults. Growth is easily
      monitored, gender can be differentiated before maturity, and maturation is
      indicated by wings and mature genitalia. Crickets can be reared in large numbers 
      at low cost. Test materials can be mixed into food and ingestion rates or mass
      budgets easily assessed. Here, we validate the cricket as a model of aging by
      testing two fundamental methods of restricting food intake: time-restricted
      access to food and dietary dilution. Growth, maturation, survivorship, and
      longevity varied with treatments and genders. Intermittent feeding (which is
      ineffective in flies) significantly extended longevity of crickets. Dietary
      dilution also extended longevity via remarkable prolongation of the juvenile
      period.
FAU - Lyn, Janice Christina
AU  - Lyn JC
AD  - Department of Biology, McMaster University, Hamilton, Ontario, Canada.
FAU - Naikkhwah, Wida
AU  - Naikkhwah W
FAU - Aksenov, Vadim
AU  - Aksenov V
FAU - Rollo, C David
AU  - Rollo CD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101201
PL  - Netherlands
TA  - Age (Dordr)
JT  - Age (Dordrecht, Netherlands)
JID - 101250497
SB  - IM
MH  - *Aging
MH  - Animal Feed
MH  - Animals
MH  - Energy Intake
MH  - Female
MH  - *Food Deprivation
MH  - Gryllidae/growth & development/*physiology
MH  - Life Cycle Stages
MH  - *Longevity
MH  - Male
MH  - *Models, Animal
PMC - PMC3220405
EDAT- 2010/12/02 06:00
MHDA- 2012/02/22 06:00
CRDT- 2010/12/02 06:00
PHST- 2010/07/07 00:00 [received]
PHST- 2010/11/01 00:00 [accepted]
PHST- 2010/12/02 06:00 [entrez]
PHST- 2010/12/02 06:00 [pubmed]
PHST- 2012/02/22 06:00 [medline]
AID - 10.1007/s11357-010-9195-z [doi]
PST - ppublish
SO  - Age (Dordr). 2011 Dec;33(4):509-22. doi: 10.1007/s11357-010-9195-z. Epub 2010 Dec
      1.


PMID- 21120420
OWN - NLM
STAT- MEDLINE
DCOM- 20110404
LR  - 20190608
IS  - 0104-1169 (Print)
IS  - 0104-1169 (Linking)
VI  - 18
IP  - 5
DP  - 2010 Sep-Oct
TI  - Iatrogenesis in intensive care units: dramatization of contemporary bio/ethical
      problems.
PG  - 990-7
LID - S0104-11692010000500021 [pii]
AB  - This qualitative investigation, based in Foucauldian analysis with approximations
      to the post-structuralism theoretical framework, explores iatrogenesis as one of 
      the tensions in the nursing to do/to know which can be discursively articulated
      to bioethics and to technobiomedicine. The documentary sources and intensive
      interviews with nurses, permitted the activation of a reflection on the act of
      the nurse in a context permeated by the ever-present possibility of failure in
      both the procedure and in the conduct and, from this possibility, they should
      meet their obligation to correct this failure not so much or not only in
      knowledge, not so much or not only in law but in practice itself.
FAU - de Oliveira Vargas, Mara Ambrosina
AU  - de Oliveira Vargas MA
AD  - Universidade do Vale do Rio dos Sinos, Departamento de Enfermagem. RS, Brazil.
      maraav@unisinos.br
FAU - Ramos, Flavia Regina Souza
AU  - Ramos FR
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - Rev Lat Am Enfermagem
JT  - Revista latino-americana de enfermagem
JID - 9420934
MH  - *Attitude of Health Personnel
MH  - *Bioethical Issues
MH  - *Ethics, Nursing
MH  - Humans
MH  - *Iatrogenic Disease
MH  - Intensive Care Units/*standards
MH  - Interviews as Topic
MH  - Nursing/*standards
EDAT- 2010/12/02 06:00
MHDA- 2011/04/05 06:00
CRDT- 2010/12/02 06:00
PHST- 2009/12/04 00:00 [received]
PHST- 2010/07/15 00:00 [accepted]
PHST- 2010/12/02 06:00 [entrez]
PHST- 2010/12/02 06:00 [pubmed]
PHST- 2011/04/05 06:00 [medline]
AID - S0104-11692010000500021 [pii]
AID - 10.1590/s0104-11692010000500021 [doi]
PST - ppublish
SO  - Rev Lat Am Enfermagem. 2010 Sep-Oct;18(5):990-7. doi:
      10.1590/s0104-11692010000500021.


PMID- 21120409
OWN - NLM
STAT- MEDLINE
DCOM- 20110404
LR  - 20190608
IS  - 0104-1169 (Print)
IS  - 0104-1169 (Linking)
VI  - 18
IP  - 5
DP  - 2010 Sep-Oct
TI  - Prevalence of urinary incontinence in a random sample of the urban population of 
      Pouso Alegre, Minas Gerais, Brazil.
PG  - 903-10
LID - S0104-11692010000500010 [pii]
AB  - This study determines and analyzes the prevalence of Urinary Incontinence (UI)
      and its demographic and clinical predictors. This epidemiological and
      cross-sectional study was approved by the Research Ethics Committee of the
      University of Sao Paulo, Nursing School. The sample was randomly selected by
      cluster technique and included 519 individuals aged>/=18 years, living in 341
      houses in urban areas. Data were analyzed through Chi-Square, Hosmer Lemeshow's
      test and multivariate logistic regression (stepwise). Prevalence rates were
      standardized by gender and age. Of the 519 people composing the sample: 20.1% had
      UI, 32.9% were women and 6.2% were men. Longer duration of losses (OR=29.3;
      p<0.001), diabetes mellitus (OR=17.7; p<0.001), stroke (OR=15.9; p<0.001), and
      cystocele (OR=12.5; p<0.001) were the factors most strongly associated with UI.
      This study enabled the identification of UI epidemiology and can contribute to
      the development of public policies for its primary and secondary prevention and
      treatment, even if such measures are initially implemented at the city level.
FAU - de Souza Santos, Claudia Regina
AU  - de Souza Santos CR
AD  - Universidade de Lavras, MG, Brazil. claudiasantos8@hotmail.com
FAU - Santos, Vera Lucia Conceicao Gouveia
AU  - Santos VL
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Brazil
TA  - Rev Lat Am Enfermagem
JT  - Revista latino-americana de enfermagem
JID - 9420934
MH  - Adolescent
MH  - Adult
MH  - Brazil/epidemiology
MH  - Chi-Square Distribution
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Prevalence
MH  - Primary Prevention
MH  - Random Allocation
MH  - Secondary Prevention
MH  - Sex Factors
MH  - Urban Population
MH  - Urinary Incontinence/*epidemiology/nursing/prevention & control/therapy
EDAT- 2010/12/02 06:00
MHDA- 2011/04/05 06:00
CRDT- 2010/12/02 06:00
PHST- 2009/05/21 00:00 [received]
PHST- 2010/03/17 00:00 [accepted]
PHST- 2010/12/02 06:00 [entrez]
PHST- 2010/12/02 06:00 [pubmed]
PHST- 2011/04/05 06:00 [medline]
AID - S0104-11692010000500010 [pii]
AID - 10.1590/s0104-11692010000500010 [doi]
PST - ppublish
SO  - Rev Lat Am Enfermagem. 2010 Sep-Oct;18(5):903-10. doi:
      10.1590/s0104-11692010000500010.


PMID- 21119861
OWN - NLM
STAT- MEDLINE
DCOM- 20110103
LR  - 20211020
IS  - 0008-5286 (Print)
IS  - 0008-5286 (Linking)
VI  - 51
IP  - 9
DP  - 2010 Sep
TI  - An ethicist's commentary on whether or not animal welfare should be market-based.
PG  - 936
FAU - Rollin, Bernard E
AU  - Rollin BE
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Vet J
JT  - The Canadian veterinary journal = La revue veterinaire canadienne
JID - 0004653
SB  - IM
MH  - Animal Husbandry/*ethics/methods
MH  - Animal Welfare/*ethics/legislation & jurisprudence
MH  - Animals
MH  - Canada
MH  - *Commerce
MH  - Humans
MH  - Morale
MH  - Socioeconomic Factors
MH  - Veterinarians/ethics
MH  - Veterinary Medicine/*ethics/methods
PMC - PMC2920168
EDAT- 2010/12/02 06:00
MHDA- 2011/01/05 06:00
CRDT- 2010/12/02 06:00
PHST- 2010/12/02 06:00 [entrez]
PHST- 2010/12/02 06:00 [pubmed]
PHST- 2011/01/05 06:00 [medline]
PST - ppublish
SO  - Can Vet J. 2010 Sep;51(9):936.


PMID- 21119593
OWN - NLM
STAT- MEDLINE
DCOM- 20110316
LR  - 20110614
IS  - 1643-3750 (Electronic)
IS  - 1234-1010 (Linking)
VI  - 16
IP  - 12
DP  - 2010 Dec
TI  - Telemedicine: medical, legal and ethical perspectives.
PG  - RA261-72
AB  - Technological innovations in medical care have led to the development of
      telemedicine programs in both rural and urban environments. The necessity for
      telemedicine has increased immensely as more cost-effective treatment options
      have become available for both patients and physicians through the addition of
      telecommunication technologies to medical practice. The development of
      telemedicine systems began as a means of providing access to health care
      resources for individuals living in isolated rural areas, grew into advanced
      medical intervention techniques for soldiers on the battlefield, and have become 
      prevalent in urban medical centers both as a resource to the underserved
      populations and as a platform for physicians off-site to conduct patient consults
      remotely. Urban telemedicine systems, as monitored in the Mercy Health System
      (Philadelphia, Pennsylvania) and AtlantiCare Regional Medical Center (Atlantic
      City, New Jersey), display the enormous benefits of telemedicine as a form of
      preliminary analysis of patients for the treatment of various medical conditions 
      including chronic disease, mental health disorders and stroke. However, the
      initiation of telemedicine programs requires new protocols and safeguards to be
      initiated to protect patient confidentiality/privacy, ensure the appropriate
      licensure of physicians practicing across state borders, and educate patients on 
      the use of new technological systems. Telemedicine represents the progression of 
      medicine in the presence of improving communication technologies and should be
      instituted in all urban medical centers. This conclusion is based upon the
      ethical responsibility to treat all persons with dignity and respect, which in
      this case, mandates the provision of the most cost-effective, beneficial medical 
      care for all populations.
FAU - Clark, Peter A
AU  - Clark PA
AD  - Institute of Catholic Bioethics, Saint Joseph's University, Philadelphia, PA
      19131, USA. pclark@sju.edu
FAU - Capuzzi, Kevin
AU  - Capuzzi K
FAU - Harrison, Joseph
AU  - Harrison J
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and
      clinical research
JID - 9609063
SB  - IM
MH  - Cost-Benefit Analysis
MH  - History, 19th Century
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Telemedicine/economics/*ethics/history/*legislation &
      jurisprudence/*methods/trends
EDAT- 2010/12/02 06:00
MHDA- 2011/03/17 06:00
CRDT- 2010/12/02 06:00
PHST- 2010/12/02 06:00 [entrez]
PHST- 2010/12/02 06:00 [pubmed]
PHST- 2011/03/17 06:00 [medline]
AID - 881286 [pii]
PST - ppublish
SO  - Med Sci Monit. 2010 Dec;16(12):RA261-72.


PMID- 21119135
OWN - NLM
STAT- MEDLINE
DCOM- 20110322
LR  - 20190709
IS  - 1943-4723 (Electronic)
IS  - 0002-8177 (Linking)
VI  - 141
IP  - 12
DP  - 2010 Dec
TI  - Is it ethical for a specialist to demonstrate surgical techniques to a general
      dentist untrained in the procedure so that the dentist can perform these
      procedures on his or her own?
PG  - 1496-7
FAU - Palcanis, Kent G
AU  - Palcanis KG
AD  - Department of Periodontology, School of Dentistry, University of Alabama at
      Birmingham, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Am Dent Assoc
JT  - Journal of the American Dental Association (1939)
JID - 7503060
SB  - IM
MH  - American Dental Association
MH  - Codes of Ethics
MH  - Dental Care/ethics/standards
MH  - *Dental Implantation
MH  - *Ethics, Dental
MH  - General Practice, Dental/*ethics/standards
MH  - Humans
MH  - Periodontics/*ethics/standards
MH  - Teaching/ethics
MH  - United States
EDAT- 2010/12/02 06:00
MHDA- 2011/03/23 06:00
CRDT- 2010/12/02 06:00
PHST- 2010/12/02 06:00 [entrez]
PHST- 2010/12/02 06:00 [pubmed]
PHST- 2011/03/23 06:00 [medline]
AID - S0002-8177(14)60480-3 [pii]
AID - 10.14219/jada.archive.2010.0114 [doi]
PST - ppublish
SO  - J Am Dent Assoc. 2010 Dec;141(12):1496-7. doi: 10.14219/jada.archive.2010.0114.


PMID- 21118946
OWN - NLM
STAT- MEDLINE
DCOM- 20110111
LR  - 20211020
IS  - 1476-1645 (Electronic)
IS  - 0002-9637 (Linking)
VI  - 83
IP  - 6
DP  - 2010 Dec
TI  - In vitro praziquantel test capable of detecting reduced in vivo efficacy in
      Schistosoma mansoni human infections.
PG  - 1340-7
LID - 10.4269/ajtmh.2010.10-0413 [doi]
AB  - Although great reductions in human schistosomiasis have been observed after
      praziquantel (PZQ) mass drug administration (MDA), some individuals remain
      infected after multiple treatments. Many MDA programs now require monitoring for 
      drug efficacy as a key component. No molecular tools for PZQ resistance currently
      exist and investigations into the dose of PZQ required to kill 50% of adult worms
      in vivo (ED(50)) present ethical, logistical, and temporal restraints. We,
      therefore, assessed the feasibility and accuracy of a rapid, inexpensive in vitro
      PZQ test in the laboratory and directly in the field in Uganda under MDA in
      conjunction with highly detailed infection intensity, clearance, and reinfection 
      data. This test strongly differentiated between subsequently cleared and
      uncleared infections as well as differences between parasite populations pre- and
      post-PZQ treatments, advocating its use for on-the-spot monitoring of PZQ
      efficacy in natural foci. After only a few treatments, uncleared parasites were
      identified to be phenotypically different from drug-sensitive parasites,
      emphasizing the urgent need for monitoring of these repeatedly PZQ-treated
      populations.
FAU - Lamberton, Poppy H L
AU  - Lamberton PH
AD  - Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial
      College London, London, United Kingdom. poppy.lamberton@imperial.ac.uk
FAU - Hogan, Sarah C
AU  - Hogan SC
FAU - Kabatereine, Narcis B
AU  - Kabatereine NB
FAU - Fenwick, Alan
AU  - Fenwick A
FAU - Webster, Joanne P
AU  - Webster JP
LA  - eng
GR  - Medical Research Council/United Kingdom
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Trop Med Hyg
JT  - The American journal of tropical medicine and hygiene
JID - 0370507
RN  - 6490C9U457 (Praziquantel)
SB  - IM
MH  - Animals
MH  - Child
MH  - Dose-Response Relationship, Drug
MH  - Drug Resistance
MH  - Female
MH  - Humans
MH  - Male
MH  - Praziquantel/*pharmacology
MH  - Schistosoma mansoni/*drug effects
MH  - Schistosomiasis mansoni/*drug therapy/epidemiology/*parasitology
MH  - Uganda/epidemiology
PMC - PMC2990056
EDAT- 2010/12/02 06:00
MHDA- 2011/01/12 06:00
CRDT- 2010/12/02 06:00
PHST- 2010/12/02 06:00 [entrez]
PHST- 2010/12/02 06:00 [pubmed]
PHST- 2011/01/12 06:00 [medline]
AID - 83/6/1340 [pii]
AID - 10.4269/ajtmh.2010.10-0413 [doi]
PST - ppublish
SO  - Am J Trop Med Hyg. 2010 Dec;83(6):1340-7. doi: 10.4269/ajtmh.2010.10-0413.


PMID- 21118918
OWN - NLM
STAT- MEDLINE
DCOM- 20110111
LR  - 20220408
IS  - 1476-1645 (Electronic)
IS  - 0002-9637 (Linking)
VI  - 83
IP  - 6
DP  - 2010 Dec
TI  - Ethics and best practice guidelines for training experiences in global health.
PG  - 1178-82
LID - 10.4269/ajtmh.2010.10-0527 [doi]
AB  - Academic global health programs are growing rapidly in scale and number. Students
      of many disciplines increasingly desire global health content in their curricula.
      Global health curricula often include field experiences that involve crossing
      international and socio-cultural borders. Although global health training
      experiences offer potential benefits to trainees and to sending institutions,
      these experiences are sometimes problematic and raise ethical challenges. The
      Working Group on Ethics Guidelines for Global Health Training (WEIGHT) developed 
      a set of guidelines for institutions, trainees, and sponsors of field-based
      global health training on ethics and best practices in this setting. Because only
      limited data have been collected within the context of existing global health
      training, the guidelines were informed by the published literature and the
      experience of WEIGHT members. The Working Group on Ethics Guidelines for Global
      Health Training encourages efforts to develop and implement a means of assessing 
      the potential benefits and harms of global health training programs.
FAU - Crump, John A
AU  - Crump JA
AD  - Division of Infectious Diseases and International Health, Duke University Medical
      Center, Durham, North Carolina 27710, USA. crump017@mc.duke.edu
FAU - Sugarman, Jeremy
AU  - Sugarman J
CN  - Working Group on Ethics Guidelines for Global Health Training (WEIGHT)
LA  - eng
GR  - WT089272MF/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Trop Med Hyg
JT  - The American journal of tropical medicine and hygiene
JID - 0370507
SB  - IM
CIN - Am J Trop Med Hyg. 2011 Mar;84(3):506; author reply 507. PMID: 21363994
MH  - Bioethical Issues
MH  - Cultural Characteristics
MH  - Curriculum
MH  - Delivery of Health Care/methods
MH  - Education, Professional/*ethics/*standards
MH  - *Ethics, Medical
MH  - *Global Health
MH  - Humans
MH  - *International Educational Exchange
MH  - Practice Guidelines as Topic
MH  - Public Health/ethics
PMC - PMC2990028
IR  - Barry M
FIR - Barry, Michele
IR  - Bhan A
FIR - Bhan, Anant
IR  - Gardner P
FIR - Gardner, Pierce
IR  - Koplan JP
FIR - Koplan, Jeffrey P
IR  - Kulanga AT
FIR - Kulanga, Ahaz T
IR  - Montano SM
FIR - Montano, Silvia M
IR  - Myers E
FIR - Myers, Elizabeth
IR  - Patrick K
FIR - Patrick, Kirsten
IR  - Porter JD
FIR - Porter, John D
IR  - Regenberg AC
FIR - Regenberg, Alan C
IR  - Ruxrungtham K
FIR - Ruxrungtham, Kiat
IR  - Sewankambo NK
FIR - Sewankambo, Nelson K
IR  - Shao JF
FIR - Shao, John F
EDAT- 2010/12/02 06:00
MHDA- 2011/01/12 06:00
CRDT- 2010/12/02 06:00
PHST- 2010/12/02 06:00 [entrez]
PHST- 2010/12/02 06:00 [pubmed]
PHST- 2011/01/12 06:00 [medline]
AID - 83/6/1178 [pii]
AID - 10.4269/ajtmh.2010.10-0527 [doi]
PST - ppublish
SO  - Am J Trop Med Hyg. 2010 Dec;83(6):1178-82. doi: 10.4269/ajtmh.2010.10-0527.


PMID- 21118584
OWN - NLM
STAT- MEDLINE
DCOM- 20110627
LR  - 20101201
IS  - 1876-8784 (Electronic)
IS  - 0028-2162 (Linking)
VI  - 154
IP  - 45
DP  - 2010
TI  - [Vegetative or minimally conscious state?].
PG  - A1890
AB  - We describe the clinical course of a 51-year-old woman in a vegetative state and 
      of a 63-year-old woman in a minimally conscious state. The difference between
      these two states is an important one, as clinical course, prognosis and
      medical-ethical considerations of both are different. In practice it is difficult
      to distinguish between a vegetative state and a minimally conscious state, but
      the use of a Post-Acute Level of Consciousness scale helps to illustrate the
      differences. Expertise, research, and application of functional neuro-imaging
      techniques (PET, fMRI) might also be useful. The differences between these two
      states regarding rehabilitation, pain management and medical-ethical decisions
      are important. The effects of neuro-rehabilitation and the implications of a
      minimally conscious state for patients and their proxies need further
      investigation.
FAU - Overbeek, Berno U H
AU  - Overbeek BU
AD  - Sensire verpleeghuis Den Ooiman, Doetinchem, the Netherlands.
FAU - Lavrijsen, Jan C M
AU  - Lavrijsen JC
FAU - Eilander, Henk J
AU  - Eilander HJ
LA  - dut
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - Vegetatief of laagbewust? Het moeilijke onderscheid tussen niets weten en een
      beetje.
PL  - Netherlands
TA  - Ned Tijdschr Geneeskd
JT  - Nederlands tijdschrift voor geneeskunde
JID - 0400770
SB  - IM
MH  - Awareness
MH  - Brain/pathology
MH  - Consciousness Disorders/*diagnosis
MH  - Diagnosis, Differential
MH  - Electrophysiology
MH  - *Ethics, Medical
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Middle Aged
MH  - Persistent Vegetative State/*diagnosis
MH  - Positron-Emission Tomography
MH  - Prognosis
EDAT- 2010/12/02 06:00
MHDA- 2011/06/28 06:00
CRDT- 2010/12/02 06:00
PHST- 2010/12/02 06:00 [entrez]
PHST- 2010/12/02 06:00 [pubmed]
PHST- 2011/06/28 06:00 [medline]
PST - ppublish
SO  - Ned Tijdschr Geneeskd. 2010;154(45):A1890.


PMID- 21118352
OWN - NLM
STAT- MEDLINE
DCOM- 20111006
LR  - 20110727
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 11
IP  - 2
DP  - 2011 Aug
TI  - Justice in international clinical research.
PG  - 75-81
LID - 10.1111/j.1471-8847.2010.00296.x [doi]
AB  - Debates about justice in international clinical research problematically conflate
      two quite different forms of obligation. International research ethics guidelines
      were intended to describe how to conduct biomedical research in a just manner at 
      the micro or clinical level (within the researcher-participant interaction) but
      have come to include requirements that are clearly intended to promote justice at
      the global level. Ethicists have also made a variety of claims regarding what
      international research should contribute to global justice. This paper argues
      that the conflation of debates about justice at the micro and macro-levels has
      not only resulted in the placement of obligations upon the wrong actors but has
      also served to exclude relevant actors from the ethical picture. Suggestions for 
      who should properly bear macro-level obligations of justice in international
      clinical research are offered. The paper further contends that, unlike
      researchers who violate informed consent requirements, no similar type of
      accountability exists for obligations of global justice, even for those
      obligation-bearers (incorrectly) identified by current ethics guidelines.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Pratt, Bridget
AU  - Pratt B
AD  - Michael Kirby Centre for Public Health and Human Rights, Dept. of Epidemiology
      and Preventive Medicine, Monash University, 99 Commercial Road, Melbourne,
      Victoria 3004, Australia. Bridget.Pratt@monash.edu
FAU - Loff, Bebe
AU  - Loff B
LA  - eng
PT  - Journal Article
DEP - 20101130
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
SB  - IM
MH  - Clinical Trials as Topic/*ethics
MH  - Guidelines as Topic
MH  - Health Services Accessibility/*ethics
MH  - Humans
MH  - *International Cooperation
MH  - Philosophy
MH  - Research Support as Topic/ethics
MH  - *Social Justice
MH  - *Social Responsibility
EDAT- 2010/12/02 06:00
MHDA- 2011/10/07 06:00
CRDT- 2010/12/02 06:00
PHST- 2010/12/02 06:00 [entrez]
PHST- 2010/12/02 06:00 [pubmed]
PHST- 2011/10/07 06:00 [medline]
AID - 10.1111/j.1471-8847.2010.00296.x [doi]
PST - ppublish
SO  - Dev World Bioeth. 2011 Aug;11(2):75-81. doi: 10.1111/j.1471-8847.2010.00296.x.
      Epub 2010 Nov 30.


PMID- 21117285
OWN - NLM
STAT- MEDLINE
DCOM- 20101222
LR  - 20191210
IS  - 0019-5847 (Print)
IS  - 0019-5847 (Linking)
VI  - 108
IP  - 4
DP  - 2010 Apr
TI  - Ethics in medical profession.
PG  - 252
FAU - Chaudhuri, Sujit K
AU  - Chaudhuri SK
LA  - eng
PT  - Letter
PT  - Comment
PL  - India
TA  - J Indian Med Assoc
JT  - Journal of the Indian Medical Association
JID - 7505608
SB  - IM
CON - J Indian Med Assoc. 2010 Feb;108(2):77. PMID: 20839560
MH  - Advertising/*ethics
MH  - *Education, Medical
MH  - Ethics, Medical/education
MH  - Humans
MH  - India
MH  - Physician-Patient Relations/*ethics
EDAT- 2010/12/01 06:00
MHDA- 2010/12/24 06:00
CRDT- 2010/12/01 06:00
PHST- 2010/12/01 06:00 [entrez]
PHST- 2010/12/01 06:00 [pubmed]
PHST- 2010/12/24 06:00 [medline]
PST - ppublish
SO  - J Indian Med Assoc. 2010 Apr;108(4):252.


PMID- 21116141
OWN - NLM
STAT- MEDLINE
DCOM- 20110401
LR  - 20101130
IS  - 1539-073X (Electronic)
IS  - 1520-9229 (Linking)
VI  - 12
IP  - 4
DP  - 2010 Oct-Dec
TI  - Legal and ethical implications of health care provider insurance risk assumption.
PG  - 106-16
LID - 10.1097/NHL.0b013e3181ff0fa0 [doi]
AB  - From bedside to boardroom, nurses deal with the consequences of health care
      provider insurance risk assumption. Professional caregiver insurance risk refers 
      to insurance risks assumed through contracts with third parties, federal and
      state Medicare and Medicaid program mandates, and the diagnosis-related groups
      and Prospective Payment Systems. This article analyzes the financial, legal, and 
      ethical implications of provider insurance risk assumption by focusing on the
      degree to which patient benefits are reduced.
FAU - Cox, Thomas
AU  - Cox T
AD  - nurse.statistician@yahoo.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - JONAS Healthc Law Ethics Regul
JT  - JONA'S healthcare law, ethics and regulation
JID - 100888423
MH  - Actuarial Analysis/economics/ethics/methods
MH  - Community Health Planning/ethics/legislation & jurisprudence
MH  - Cost Control
MH  - Efficiency, Organizational
MH  - Government Regulation
MH  - Guideline Adherence/ethics/legislation & jurisprudence
MH  - Guidelines as Topic
MH  - Health Services Needs and Demand/ethics/legislation & jurisprudence
MH  - Humans
MH  - *Insurance, Health/ethics/legislation & jurisprudence
MH  - Medicaid/ethics/legislation & jurisprudence
MH  - Medicare/ethics/legislation & jurisprudence
MH  - Models, Economic
MH  - Operations Research
MH  - Probability
MH  - Prospective Payment System/ethics/legislation & jurisprudence
MH  - *Risk Management/ethics/legislation & jurisprudence
MH  - *Risk Sharing, Financial/ethics/legislation & jurisprudence
MH  - United States
EDAT- 2010/12/01 06:00
MHDA- 2011/04/02 06:00
CRDT- 2010/12/01 06:00
PHST- 2010/12/01 06:00 [entrez]
PHST- 2010/12/01 06:00 [pubmed]
PHST- 2011/04/02 06:00 [medline]
AID - 10.1097/NHL.0b013e3181ff0fa0 [doi]
AID - 00128488-201010000-00005 [pii]
PST - ppublish
SO  - JONAS Healthc Law Ethics Regul. 2010 Oct-Dec;12(4):106-16. doi:
      10.1097/NHL.0b013e3181ff0fa0.


PMID- 21115372
OWN - NLM
STAT- MEDLINE
DCOM- 20110120
LR  - 20101227
IS  - 1879-1190 (Electronic)
IS  - 1072-7515 (Linking)
VI  - 212
IP  - 1
DP  - 2011 Jan
TI  - Physicomechanical evaluation of polypropylene, polyester, and
      polytetrafluoroethylene meshes for inguinal hernia repair.
PG  - 68-79
LID - 10.1016/j.jamcollsurg.2010.09.012 [doi]
AB  - BACKGROUND: For meshes to be used effectively for hernia repair, it is imperative
      that engineers and surgeons standardize the terminology and techniques related to
      physicomechanical evaluation of these materials. The objectives of this study
      were to propose standard techniques, perform physicomechanical testing, and
      classify materials commonly used for inguinal hernia repair. STUDY DESIGN: Nine
      meshes were evaluated: 4 polypropylene, 1 polyester, 1 polytetrafluoroethylene,
      and 3 partially absorbable. Physical properties were determined through image
      analysis, laser micrometry, and density measurements. Biomechanical properties
      were determined through suture retention, tear resistance, uniaxial, and ball
      burst testing with specimens tested in 2 different orientations. A 1-way ANOVA
      with Tukey's post-test or a t-test were performed, with p < 0.05. RESULTS:
      Significant differences were observed due to both mesh type and orientation.
      Areas of interstices ranged from 0.33 +/- 0.01 mm(2) for ProLite (Atrium Medical 
      Corp) and C-QUR Lite (Atrium Medical Corp) Large to 4.10 +/- 0.06 mm(2) for
      ULTRAPRO (Ethicon), and filament diameters ranged from 99.00 +/-8.1 mum for
      ProLite Ultra (Atrium Medical Corp) and C-QUR Lite Small to 338.8 +/- 3.7 mum for
      Parietex Flat Sheet TEC (Covidien). These structural characteristics influenced
      biomechanical properties such as tear resistance and tensile strength. ProLite
      Ultra, C-QUR Lite Small, ULTRAPRO and INFINIT (WL Gore & Associates) did not
      resist tearing as effectively as the others. All meshes exhibited
      supraphysiologic burst strengths except INFINIT and ULTRAPRO. CONCLUSIONS:
      Significant differences exist between the physicomechanical properties of
      polypropylene, polyester, polytetrafluoroethylene, and partially absorbable mesh 
      prostheses commonly used for inguinal hernia repair. Orientation of the mesh was 
      also shown to be critical for the success of meshes, particularly those
      demonstrating anisotropy.
CI  - Copyright (c) 2011 American College of Surgeons. Published by Elsevier Inc. All
      rights reserved.
FAU - Deeken, Corey R
AU  - Deeken CR
AD  - Department of Surgery, Washington University School of Medicine, St Louis, MO
      63110, USA. deekenc@wudosis.wustl.edu
FAU - Abdo, Michael S
AU  - Abdo MS
FAU - Frisella, Margaret M
AU  - Frisella MM
FAU - Matthews, Brent D
AU  - Matthews BD
LA  - eng
PT  - Journal Article
DEP - 20101105
PL  - United States
TA  - J Am Coll Surg
JT  - Journal of the American College of Surgeons
JID - 9431305
RN  - 0 (Polypropylenes)
RN  - 9002-84-0 (Polytetrafluoroethylene)
SB  - IM
MH  - Body Mass Index
MH  - Hernia, Inguinal/*surgery
MH  - Humans
MH  - *Materials Testing
MH  - Polypropylenes
MH  - Polytetrafluoroethylene
MH  - *Surgical Mesh
MH  - Sutures
MH  - Tensile Strength
EDAT- 2010/12/01 06:00
MHDA- 2011/01/21 06:00
CRDT- 2010/12/01 06:00
PHST- 2010/06/16 00:00 [received]
PHST- 2010/08/20 00:00 [revised]
PHST- 2010/09/01 00:00 [accepted]
PHST- 2010/12/01 06:00 [entrez]
PHST- 2010/12/01 06:00 [pubmed]
PHST- 2011/01/21 06:00 [medline]
AID - S1072-7515(10)01081-1 [pii]
AID - 10.1016/j.jamcollsurg.2010.09.012 [doi]
PST - ppublish
SO  - J Am Coll Surg. 2011 Jan;212(1):68-79. doi: 10.1016/j.jamcollsurg.2010.09.012.
      Epub 2010 Nov 5.


PMID- 21114956
OWN - NLM
STAT- MEDLINE
DCOM- 20111107
LR  - 20131121
IS  - 1873-6254 (Electronic)
IS  - 0001-706X (Linking)
VI  - 117
IP  - 2
DP  - 2011 Feb
TI  - A multimodal bait for trapping blood-sucking arthropods.
PG  - 131-6
LID - 10.1016/j.actatropica.2010.11.005 [doi]
AB  - Artificial baits constitute important tools for the detection and sampling of
      blood-sucking arthropods, in particular those that are vectors of parasites
      affecting human health. At present, many different devices have been proposed to 
      attract blood-sucking arthropods, mostly based on the attractiveness of
      particular chemicals or blends. However, most of them revealed themselves as
      unpractical (e.g. they require an electrical supply), expensive (e.g. gas
      bottles) or not efficient enough. On the other hand, the use of living baits is
      as effective but it has practical constraints and/or raises ethical questions. We
      present here a multimodal lure to attract blood-sucking arthropods designed
      taking into account both practical constraints and costs. The main
      characteristics of our bait are: (1) artificiality (no living-host); (2)
      multimodality (it associates heat, carbon dioxide and chemical attractants); (3) 
      independency from any energy source; (4) no need for gas bottles; (5) easy to
      prepare and use in the field; (6) low cost. We tested the ability of the bait to 
      attract blood-sucking arthropods in the laboratory and in the field, using
      capture sticky-traps. Our bait evinced to be almost as efficient as live hosts
      (mice) for the capture of Chagas disease and Borrelia vectors in Bolivia. The
      multimodal lure here presented is a generalist bait, i.e. effective for
      attracting different haematophagous species.
CI  - 2010 Elsevier B.V. All rights reserved.
FAU - Ryelandt, Julien
AU  - Ryelandt J
AD  - Institut de Recherche sur la Biologie de l'Insecte, UMR CNRS 6035 - Universite
      Francois Rabelais, Tours, France.
FAU - Noireau, Francois
AU  - Noireau F
FAU - Lazzari, Claudio R
AU  - Lazzari CR
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101127
PL  - Netherlands
TA  - Acta Trop
JT  - Acta tropica
JID - 0370374
RN  - 142M471B3J (Carbon Dioxide)
SB  - IM
MH  - Animal Feed
MH  - Animals
MH  - Arthropods/*physiology
MH  - Borrelia Infections/prevention & control
MH  - Carbon Dioxide
MH  - Chagas Disease/prevention & control
MH  - Hot Temperature
MH  - Humans
MH  - Insect Control/instrumentation/*methods
MH  - Insect Vectors/*physiology
EDAT- 2010/12/01 06:00
MHDA- 2011/11/08 06:00
CRDT- 2010/12/01 06:00
PHST- 2010/03/17 00:00 [received]
PHST- 2010/11/07 00:00 [revised]
PHST- 2010/11/10 00:00 [accepted]
PHST- 2010/12/01 06:00 [entrez]
PHST- 2010/12/01 06:00 [pubmed]
PHST- 2011/11/08 06:00 [medline]
AID - S0001-706X(10)00289-5 [pii]
AID - 10.1016/j.actatropica.2010.11.005 [doi]
PST - ppublish
SO  - Acta Trop. 2011 Feb;117(2):131-6. doi: 10.1016/j.actatropica.2010.11.005. Epub
      2010 Nov 27.


PMID- 21114683
OWN - NLM
STAT- MEDLINE
DCOM- 20110629
LR  - 20161125
IS  - 1365-2648 (Electronic)
IS  - 0309-2402 (Linking)
VI  - 67
IP  - 4
DP  - 2011 Apr
TI  - Exploring dual professional identities, the role of the nurse tutor in higher
      education in the UK: role complexity and tensions.
PG  - 884-92
LID - 10.1111/j.1365-2648.2010.05519.x [doi]
AB  - AIMS: This paper presents a discussion on the role of the nurse, teachers in
      mainstream education and nurse educators, reviewing theories of professional
      identity and how these theories have had an impact on practice. BACKGROUND: The
      professional identity of both the teacher and nurse aspect of the nurse educator 
      role is reviewed using historical perspectives to define the role of a nurse from
      doctor's handmaiden to autonomous practitioner, and determine society's idea of a
      teacher. DATA SOURCES: The literature reviewed for this paper has been drawn from
      the Cumulated Index Nursing And Allied Heath Literature, Educational Resources
      Information Centre, Professional Development Collection and Education-line. The
      period of literature publications taken up for review was 1960-2009 to gain a
      historical view and the main phrases used were Nurse Education and Educators,
      Nurse Roles, Professionalism and Professional Development. DISCUSSION: Issues of 
      role complexity were considered, highlighting tensions, supposed or actual and
      ethical obligation in healthcare education. The apparent need to gain
      professional status is discussed. IMPLICATIONS FOR NURSING: Tensions and
      complexities in the nurse educator's role combine, causing problems in their
      practice. Opinions are that nurse educators are expert nurses and teachers.
      Published authors believe that there is a need for the nurse educator to maintain
      specialist knowledge in nursing practice, yet there is little discussion relating
      to specializing in teaching practice. CONCLUSIONS: Combining the roles of nurse
      and teacher removes each concrete identity. A role crisis occurs when nurse
      educators may be unable to prove their professional ability in nursing or
      establish their professional position as a teacher.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Adams, Ruth
AU  - Adams R
AD  - Crownlinks International Training Network, Barking, Essex, UK.
      ruthadams68@blueyonder.co.uk
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20101129
PL  - England
TA  - J Adv Nurs
JT  - Journal of advanced nursing
JID - 7609811
SB  - IM
MH  - Attitude of Health Personnel
MH  - Career Choice
MH  - Codes of Ethics
MH  - Curriculum/trends
MH  - *Education, Nursing, Baccalaureate
MH  - Ethics, Nursing
MH  - *Faculty, Nursing
MH  - Female
MH  - Humans
MH  - Male
MH  - Nursing/trends
MH  - Nursing Research
MH  - Nursing Theory
MH  - Professional Competence/*standards
MH  - *Professional Role
MH  - Public Opinion
MH  - *Teaching
MH  - United Kingdom
EDAT- 2010/12/01 06:00
MHDA- 2011/06/30 06:00
CRDT- 2010/12/01 06:00
PHST- 2010/12/01 06:00 [entrez]
PHST- 2010/12/01 06:00 [pubmed]
PHST- 2011/06/30 06:00 [medline]
AID - 10.1111/j.1365-2648.2010.05519.x [doi]
PST - ppublish
SO  - J Adv Nurs. 2011 Apr;67(4):884-92. doi: 10.1111/j.1365-2648.2010.05519.x. Epub
      2010 Nov 29.


PMID- 21114194
OWN - NLM
STAT- MEDLINE
DCOM- 20101222
LR  - 20191210
IS  - 0019-5847 (Print)
IS  - 0019-5847 (Linking)
VI  - 108
IP  - 4
DP  - 2010 Apr
TI  - February, 2010 issue of JIMA. Advertising and medical ethics.
PG  - 252
FAU - Banerjee, Shayamal Chandra
AU  - Banerjee SC
LA  - eng
PT  - Letter
PT  - Comment
PL  - India
TA  - J Indian Med Assoc
JT  - Journal of the Indian Medical Association
JID - 7505608
SB  - IM
CON - J Indian Med Assoc. 2010 Feb;108(2):77. PMID: 20839560
MH  - Advertising/*ethics
MH  - *Ethics, Medical
MH  - Humans
MH  - India
MH  - *Patient Advocacy
EDAT- 2010/12/01 06:00
MHDA- 2010/12/24 06:00
CRDT- 2010/12/01 06:00
PHST- 2010/12/01 06:00 [entrez]
PHST- 2010/12/01 06:00 [pubmed]
PHST- 2010/12/24 06:00 [medline]
PST - ppublish
SO  - J Indian Med Assoc. 2010 Apr;108(4):252.


PMID- 21114089
OWN - HMD
STAT- MEDLINE
DCOM- 20110331
LR  - 20211203
IS  - 0042-0980 (Print)
IS  - 0042-0980 (Linking)
VI  - 47
IP  - 14
DP  - 2010
TI  - Cosmopolitanism, geographical imaginaries and belonging in North London.
PG  - 2945-963
AB  - Cosmopolitanism has been described as the cultural habitus of globalisation. It
      is therefore, albeit defined somewhat loosely, often associated with ethnically
      diverse, global cities. This paper considers the extent to which London engenders
      cosmopolitan values amongst its residents. It draws on survey data from the LOCAL
      MULTIDEM study of minorities' political participation to address these themes.
      The analysis examines perceptions of respect, belonging and geographical
      imaginaries - amongst established minorities and the ethnic majority - in north
      London. It is argued that cosmopolitan ethics are transformative and dialectical 
      and, critically, cannot remain the preserve of the privileged in multi-ethnic
      neighbourhoods. The analysis presented demonstrates that a sense of belonging and
      cosmopolitan imaginaries are not evenly accessed by different ethnic groups;
      notably, that Bangladeshi Londoners who are born and bred in the city are less
      likely to appropriate these discourses than Caribbean, Indian or White residents.
FAU - Devadason, Ranji
AU  - Devadason R
AD  - University of Bristol.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - England
TA  - Urban Stud
JT  - Urban studies (Edinburgh, Scotland)
JID - 100970552
MH  - *Acculturation/history
MH  - Community Networks/economics/history/legislation & jurisprudence
MH  - *Ethnicity/education/ethnology/history/legislation & jurisprudence/psychology
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - London/ethnology
MH  - *Residence Characteristics/history
MH  - Social Change/history
MH  - Social Identification
MH  - *Urban Health/history
MH  - *Urban Population/history
EDAT- 2010/12/01 06:00
MHDA- 2011/04/01 06:00
CRDT- 2010/12/01 06:00
PHST- 2010/12/01 06:00 [entrez]
PHST- 2010/12/01 06:00 [pubmed]
PHST- 2011/04/01 06:00 [medline]
AID - 10.1177/0042098009360228 [doi]
PST - ppublish
SO  - Urban Stud. 2010;47(14):2945-963. doi: 10.1177/0042098009360228.


PMID- 30546267
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1380-3603 (Print)
IS  - 1380-3603 (Linking)
VI  - 16
IP  - 3
DP  - 2010 Dec
TI  - Relational Personhood, Social Justice and the Common Good: Catholic Contributions
      toward a Public Health Ethics.
PG  - 296-313
LID - 10.1093/cb/cbq022 [doi]
AB  - Worldwide, there is renewed public and political attention focused on public
      health fueled by the globally explosive H1N1 pandemic. Pandemic planning emerged 
      as a major area for public action in the absence of an overarching ethics
      framework appropriate for the community and population focus of public health.
      Baylis, Sherwin, and Kenny propose relational personhood and relational
      solidarity as core values for a public health ethics. The Catholic faith
      tradition makes three useful contributions in support of a relational ethic:
      first, a religious ontology that aligns with the view that human persons are
      inherently relational; second, a coherent account of the requisite social and
      communal ideals and structures that this belief demands; and third, inspiration
      and motivation for the attitudes and actions that are required in response to a
      relational ontology.
FAU - Appleby, Brenda
AU  - Appleby B
AD  - St. Francis Xavier University, Antigonish, Nova Scotia, Canada.
FAU - Kenny, Nuala P
AU  - Kenny NP
AD  - Dalhousie University, Halifax, Nova Scotia, Canada.
LA  - eng
PT  - Journal Article
DEP - 20101224
PL  - United States
TA  - Christ Bioeth
JT  - Christian bioethics
JID - 9507416
PMC - PMC6283016
OTO - NOTNLM
OT  - common good
OT  - ethics
OT  - public health
OT  - relational personhood
OT  - relational solidarity
OT  - social justice
EDAT- 2010/12/01 00:00
MHDA- 2010/12/01 00:01
CRDT- 2018/12/15 06:00
PHST- 2018/12/15 06:00 [entrez]
PHST- 2010/12/01 00:00 [pubmed]
PHST- 2010/12/01 00:01 [medline]
AID - 10.1093/cb/cbq022 [doi]
PST - ppublish
SO  - Christ Bioeth. 2010 Dec;16(3):296-313. doi: 10.1093/cb/cbq022. Epub 2010 Dec 24.


PMID- 25859766
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150414
LR  - 20150411
IS  - 1728-0583 (Print)
IS  - 1728-0583 (Linking)
VI  - 22
IP  - 2
DP  - 2010 Dec
TI  - Challenges in international collaboration in child and adolescent psychiatry.
PG  - 83-9
LID - 10.2989/17280583.2010.528577 [doi]
AB  - International collaboration in child and adolescent psychiatry has historically
      been weak and fragmented. The field has also lagged in developing remedies for
      improving collaboration. This article identifies barriers to successful
      collaboration and examines problems in the areas of finance, professional
      development, knowledge dissemination, professional organisations, public policy
      and the political environment, priority setting, nomenclature, as well as ethical
      challenges. The article then identifies some promising initiatives and proposes
      solutions to improve international collaboration in child and adolescent mental
      health.
FAU - Hamoda, Hesham M
AU  - Hamoda HM
AD  - a Children's Hospital Global Partnerships in Psychiatry, Children's Hospital
      Boston and Harvard, Medical School , 300 Longwood Ave , Boston , MA , 02115 ,
      USA.
FAU - Belfer, Myron L
AU  - Belfer ML
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - J Child Adolesc Ment Health
JT  - Journal of child and adolescent mental health
JID - 101242019
EDAT- 2010/12/01 00:00
MHDA- 2010/12/01 00:01
CRDT- 2015/04/11 06:00
PHST- 2015/04/11 06:00 [entrez]
PHST- 2010/12/01 00:00 [pubmed]
PHST- 2010/12/01 00:01 [medline]
AID - 10.2989/17280583.2010.528577 [doi]
PST - ppublish
SO  - J Child Adolesc Ment Health. 2010 Dec;22(2):83-9. doi:
      10.2989/17280583.2010.528577.


PMID- 25814134
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150328
LR  - 20150327
IS  - 2005-727X (Print)
IS  - 2005-727X (Linking)
VI  - 22
IP  - 4
DP  - 2010 Dec
TI  - Exploration of a leadership competency model for medical school faculties in
      Korea.
PG  - 313-21
LID - 10.3946/kjme.2010.22.4.313 [doi]
AB  - PURPOSE: To adapt to rapid and turbulent changes in the field of medicine,
      education, and society, medical school faculties need appropriate leadership. To 
      develop leadership competencies through education, coaching, and mentoring, we
      need a leadership competency model. The purpose of this study was to develop a
      new leadership competency model that is suitable for medical school faculties in 
      Korea. METHODS: To collect behavioral episodes with regard to leadership, we
      interviewed 54 subjects (faculties, residents, nurses) and surveyed 41 faculties 
      with open-ended questionnaires. We classified the behavioral episodes based on
      Quinn and Cameron's leadership competency model and developed a Likert scale
      questionnaire to perform a confirmatory factor analysis. Two hundred seven
      medical school faculties responded to the questionnaire. RESULTS: The competency 
      clusters that were identified by factor analysis were professionalism,
      citizenship, leadership, and membership to an organization. Accordingly, each
      cluster was linked with a dimension: self, society, team (that he/she is
      leading), and organization (to which he/she belongs). The clusters of
      competencies were: professional ability, ethics/morality, self-management,
      self-development, and passion; public interest, networking, social participation,
      and active service; motivating, caring, promoting teamwork, nurturing, conflict
      management, directing, performance management, and systems thinking;
      organizational orientation, collaboration, voluntary participation, and
      cost-benefit orientation. CONCLUSION: This competency model that fits medical
      school faculties in Korea can be used to design and develop selection plans,
      education programs, feedback tools, diagnostic evaluation tools, and career plan 
      support programs.
FAU - Lee, Yong Seok
AU  - Lee YS
AD  - ORP Institute, Seoul, Korea.
FAU - Oh, Dong Keun
AU  - Oh DK
AD  - ORP Institute, Seoul, Korea.
FAU - Kim, Myungun
AU  - Kim M
AD  - Department of Psychology, Seoul National University, Seoul, Korea.
FAU - Lee, Yoon Seong
AU  - Lee YS
AD  - Department of Forensic Medicine, Seoul National University College of Medicine,
      Seoul, Korea.
FAU - Shin, Jwa Seop
AU  - Shin JS
AD  - Division of Medical Education, Seoul National University College of Medicine,
      Seoul, Korea.
LA  - eng
PT  - Journal Article
DEP - 20101231
PL  - Korea (South)
TA  - Korean J Med Educ
JT  - Korean journal of medical education
JID - 101503071
OTO - NOTNLM
OT  - Citizenship
OT  - Leadership skill
OT  - Membership
OT  - Professionalism
EDAT- 2010/12/01 00:00
MHDA- 2010/12/01 00:01
CRDT- 2015/03/28 06:00
PHST- 2010/09/17 00:00 [received]
PHST- 2010/11/03 00:00 [accepted]
PHST- 2015/03/28 06:00 [entrez]
PHST- 2010/12/01 00:00 [pubmed]
PHST- 2010/12/01 00:01 [medline]
AID - kjme.2010.22.4.313 [pii]
AID - 10.3946/kjme.2010.22.4.313 [doi]
PST - ppublish
SO  - Korean J Med Educ. 2010 Dec;22(4):313-21. doi: 10.3946/kjme.2010.22.4.313. Epub
      2010 Dec 31.


PMID- 25814130
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150328
LR  - 20150327
IS  - 2005-727X (Print)
IS  - 2005-727X (Linking)
VI  - 22
IP  - 4
DP  - 2010 Dec
TI  - Impacts of problem-based professionalism course in dental education.
PG  - 275-81
LID - 10.3946/kjme.2010.22.4.275 [doi]
AB  - PURPOSE: This study explores the effects of a professionalism course based on
      problem-based learning (PBL) for 2nd year dental students on professional role
      concept and on ethical reasoning. It also investigates students' attitudes toward
      professionalism development program. METHODS: The experimental group (n=36)
      participated in the 5-week professionalism course, which uses PBL approach while 
      the control group (n=89) did not receive the professionalism instruction during
      the same period. The professionalism development program was implemented via
      discussions among students in small-group tutorial. Four professors, who served
      as group facilitators participated in faculty seminars before every tutorial.
      After each tutorial, students had to write essays on the cases they discussed in 
      their groups. Both groups completed Professional Role Orientation Inventory and
      Defining Issue Test (KDIT) prior to and post intervention period. The
      experimental group also responded to questionnaires about the value of
      professionalism program. RESULTS: Analysis of covariance indicated that the
      experimental group's responsibility score significantly improved (F=32.552,
      p<0.001) while their perception of agency decreased (F=29.510, p<0.001). The
      program had little influence on ethical reasoning measured by DIT. Twenty-eight
      students (78%) responded that they learned the value of other opinions. Seventy
      percent of the students responded that the course is worthwhile or very
      worthwhile. CONCLUSION: The result reveals that students' professional role
      concept is associated with the learning experience in professionalism program
      based on PBL. Opportunities to think of professionalism in clinical situations
      improved students' sense of responsibility as dentist.
FAU - Ji, Young A
AU  - Ji YA
AD  - Center for Educational Development in Dentistry, Seoul National University School
      of Dentistry, Seoul, Korea.
FAU - Kim, Min Kang
AU  - Kim MK
AD  - Faculty of Educational and Social Work, University of Sydney, Sydney, Australia.
FAU - Lee, Jae Il
AU  - Lee JI
AD  - Department of Pathology, Seoul National University School of Dentistry, Seoul,
      Korea.
LA  - eng
PT  - Journal Article
DEP - 20101231
PL  - Korea (South)
TA  - Korean J Med Educ
JT  - Korean journal of medical education
JID - 101503071
OTO - NOTNLM
OT  - Dental education
OT  - Dental ethics
OT  - Problem-based learning
OT  - Professional competence
EDAT- 2010/12/01 00:00
MHDA- 2010/12/01 00:01
CRDT- 2015/03/28 06:00
PHST- 2010/10/06 00:00 [received]
PHST- 2010/11/08 00:00 [accepted]
PHST- 2015/03/28 06:00 [entrez]
PHST- 2010/12/01 00:00 [pubmed]
PHST- 2010/12/01 00:01 [medline]
AID - kjme.2010.22.4.275 [pii]
AID - 10.3946/kjme.2010.22.4.275 [doi]
PST - ppublish
SO  - Korean J Med Educ. 2010 Dec;22(4):275-81. doi: 10.3946/kjme.2010.22.4.275. Epub
      2010 Dec 31.


PMID- 25610144
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150122
LR  - 20201001
IS  - 1308-8734 (Print)
IS  - 1308-8734 (Linking)
VI  - 42
IP  - 3
DP  - 2010 Dec
TI  - The effects of dexmedetomidine on ischemia reperfusion injury in patients
      undergoing arthroscopy under spinal anesthesia.
PG  - 137-41
LID - 10.5152/eajm.2010.38 [doi]
AB  - OBJECTIVE: Ischemia and reperfusion injury due to tourniquet application during
      arthroscopy is a well known problem. This study aimed to compare the effects of
      dexmedetomidine and ketamine on hemodynamic and respiratory variables and on
      total anti-oxidant status (TAS), total oxidant status (TOS) and malondialdehyde
      (MDA) as markers of ischemia-reperfusion injury. MATERIALS AND METHODS: This
      study was approved by a local ethics committee. The study was performed on
      patients undergoing arthroscopic operation under spinal anesthesia. Thirty
      patients were randomized into two groups: Group D (dexmedetomidine; n=15) and
      Group K (Ketamine; n=15). Spinal anesthesia at the L2-4 level was achieved using 
      a 25G spinal needle with hyperbaric bupivacaine at a dose of 12-15 mg in all
      patients. In Group D, patients were sedated with dexmedetomidine at a dose of
      0.3-0.5 mug/kg/h, while Group K received ketamine at a dose of 1-1.5 mg/kg/h.
      Hemodynamic parameters, oxygen saturation, Ramsey sedation scale (RSS), and TAS, 
      TOS, and MDA levels were recorded. RESULTS: Demographic parameters, TAS, TOS and 
      MDA levels were similar between groups. In Group K, the TOS levels after
      tourniquet removal were significantly lower than at baseline and during the use
      of the tourniquet. Preoperative hemodynamic and respiratory variables were
      similar in both groups. Blood pressure values were decreased compared to baseline
      but these decreases were not statistically significant. CONCLUSION: In patients
      undergoing arthroscopy under spinal anesthesia, dexmedetomidine had effects
      similar to ketamine, led to insignificant alterations in hemodynamic and
      respiratory variables during surgery and had comparable effects on
      ischemia-reperfusion injury. Thus, we think that dexmedetomidine can be a safe
      alternative to ketamine as an intraoperative sedative.
FAU - Koruk, Senem
AU  - Koruk S
AD  - Department of Anesthesiology and Reanimation, Medical School, Gaziantep
      University, Gaziantep, Turkey.
FAU - Mizrak, Ayse
AU  - Mizrak A
AD  - Department of Anesthesiology and Reanimation, Medical School, Gaziantep
      University, Gaziantep, Turkey.
FAU - Kaya, Recai
AU  - Kaya R
AD  - Department of Anesthesiology and Reanimation, Medical School, Gaziantep
      University, Gaziantep, Turkey.
FAU - Ugur, Berna
AU  - Ugur B
AD  - Department of Anesthesiology and Reanimation, Medical School, Gaziantep
      University, Gaziantep, Turkey.
FAU - Cebesoy, Oguz
AU  - Cebesoy O
AD  - Department of Orthopedics, Medical School, Gaziantep University, Gaziantep,
      Turkey.
FAU - Celik, Ahmet
AU  - Celik A
AD  - Department of Biochemistry, Medical School, Gaziantep University, Gaziantep,
      Turkey.
FAU - Oner, Unsal
AU  - Oner U
AD  - Department of Anesthesiology and Reanimation, Medical School, Gaziantep
      University, Gaziantep, Turkey.
LA  - eng
PT  - Journal Article
PL  - Turkey
TA  - Eurasian J Med
JT  - The Eurasian journal of medicine
JID - 101557701
PMC - PMC4261259
OTO - NOTNLM
OT  - Dexmedetomidine
OT  - Ischemia reperfusion
OT  - Ketamine
OT  - Oxidative stress
EDAT- 2010/12/01 00:00
MHDA- 2010/12/01 00:01
CRDT- 2015/01/23 06:00
PHST- 2010/10/06 00:00 [received]
PHST- 2010/10/21 00:00 [accepted]
PHST- 2015/01/23 06:00 [entrez]
PHST- 2010/12/01 00:00 [pubmed]
PHST- 2010/12/01 00:01 [medline]
AID - 10.5152/eajm.2010.38 [doi]
AID - eajm-42-3-137 [pii]
PST - ppublish
SO  - Eurasian J Med. 2010 Dec;42(3):137-41. doi: 10.5152/eajm.2010.38.


PMID- 25210214
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220410
IS  - 0362-3319 (Print)
IS  - 0362-3319 (Linking)
VI  - 47
IP  - 4
DP  - 2010 Dec 1
TI  - Ethical Problems with Infertility Treatments: Attitudes and Explanations.
PG  - 731-746
AB  - Although media coverage of infertility treatments has increased markedly over the
      past decade, there is a dearth of empirical information about public perceptions 
      of the ethics of infertility procedures (e.g. artificial insemination, in-vitro
      fertilization, donor eggs, surrogate mothering, gestational carriers) and about
      the factors that shape them. Two representative telephone survey samples (930
      adults in a Midwestern state, and 580 adult women aged 25 to 50 in the North
      Central region) are analyzed to gauge public views on the ethics of infertility
      treatments and estimate the effects of social structure and exposure on these
      views. Ethical concerns were viewed as more serious for techniques that could
      result in a child who may not be biologically related to the woman or her partner
      than for those yielding a child biologically related to both parents. Social
      structural factors such as age and education were the strongest predictors of
      attitudes towards the ethics of infertility treatments. Neither parenthood nor
      experiencing infertility was related to ethical concerns, although women
      reporting the use of infertility services had fewer ethical concerns than their
      counterparts.
FAU - Shreffler, Karina M
AU  - Shreffler KM
AD  - Department of Human Development and Family Studies karina.shreffler@okstate.edu
      Oklahoma State University Stillwater, OK 74074.
FAU - Johnson, David R
AU  - Johnson DR
AD  - Sociology and Human Development and Family Studies drj10@psu.edu.
FAU - Scheuble, Laurie K
AU  - Scheuble LK
AD  - Department of Sociology The Pennsylvania State University University Park, PA
      16802 lks12@psu.edu.
LA  - eng
GR  - R01 HD044144/HD/NICHD NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Soc Sci J
JT  - The Social science journal
JID - 100970479
PMC - PMC4157571
MID - NIHMS600503
EDAT- 2010/12/01 00:00
MHDA- 2010/12/01 00:01
CRDT- 2014/09/12 06:00
PHST- 2014/09/12 06:00 [entrez]
PHST- 2010/12/01 00:00 [pubmed]
PHST- 2010/12/01 00:01 [medline]
AID - 10.1016/j.soscij.2010.07.012 [doi]
PST - ppublish
SO  - Soc Sci J. 2010 Dec 1;47(4):731-746. doi: 10.1016/j.soscij.2010.07.012.


PMID- 23627011
OWN - NLM
STAT- MEDLINE
DCOM- 20130925
LR  - 20130429
IS  - 1531-7072 (Electronic)
IS  - 1070-5295 (Linking)
VI  - 16
IP  - 6
DP  - 2010 Dec
TI  - Bibliography. Current world literature. Ethical, legal and organizational issues 
      in the ICU.
PG  - 672-5
LA  - eng
PT  - Bibliography
PL  - United States
TA  - Curr Opin Crit Care
JT  - Current opinion in critical care
JID - 9504454
SB  - IM
MH  - Humans
MH  - Intensive Care Units/*ethics/*organization & administration
EDAT- 2010/12/01 00:00
MHDA- 2013/09/26 06:00
CRDT- 2013/05/01 06:00
PHST- 2013/05/01 06:00 [entrez]
PHST- 2010/12/01 00:00 [pubmed]
PHST- 2013/09/26 06:00 [medline]
PST - ppublish
SO  - Curr Opin Crit Care. 2010 Dec;16(6):672-5.


PMID- 23050899
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121210
LR  - 20160519
IS  - 1876-2026 (Electronic)
IS  - 1876-2018 (Linking)
VI  - 3
IP  - 4
DP  - 2010 Dec
TI  - A synopsis of recent influential papers published in psychiatric journals from
      the Arab World.
PG  - 244-8
LID - 10.1016/j.ajp.2010.08.011 [doi]
AB  - After a brief introduction to the Arab region, six recent and influential papers 
      that have appeared in one of the three leading psychiatry journals from the
      region are summarized. The first paper discusses the lifetime prevalence of
      mental disorders in Lebanon and assesses the influence of war. From a
      representative sample of 2857 individuals they showed that only a minority of
      individuals with a diagnosable mental disorder have received professional
      treatment. War exposure increased the risk of first onset of anxiety, mood, and
      impulse control disorders. The second paper examines the impact of ethnicity on
      psychiatric disorders in a sample of foreign workers living in Saudi Arabia. They
      concluded that ethnicity and level of employment influence both the diagnosis and
      the disposition from the ER (emergency room) with South East Asians more likely
      to be hospitalized. The next paper discusses the Inter-Rater Reliability of the
      Short Arabic Form of The Present State Examination (PSE-10) and provides evidence
      of good reliability and adequate levels of internal consistency. The next study
      provided evidence for the effectiveness of treatment by home visits from the
      community psychiatry services in reducing the number of admissions and the
      duration of hospital stays in chronic schizophrenia patients in the Kingdom of
      Bahrain. The fifth selected paper discusses the ethical and psychiatric
      implications of adolescent cosmetic surgery and provides data collected from 3300
      Arab females from ten countries. The article concludes by a discussion by the
      leading Arab psychiatrist Ahmed Okasha on new perspectives on the "social brain".
CI  - Copyright (c) 2010. Published by Elsevier B.V.
FAU - Okasha, Tarek
AU  - Okasha T
AD  - Institute of Psychiatry, Faculty of Medicine, Ain Shams University, 3, Shawarby
      Street, Kasr El Nil, Cairo, Egypt.
FAU - Boutros, Nash N
AU  - Boutros NN
LA  - eng
PT  - Journal Article
DEP - 20101118
PL  - Netherlands
TA  - Asian J Psychiatr
JT  - Asian journal of psychiatry
JID - 101517820
EDAT- 2010/12/01 00:00
MHDA- 2010/12/01 00:01
CRDT- 2012/10/12 06:00
PHST- 2010/08/05 00:00 [received]
PHST- 2010/08/11 00:00 [accepted]
PHST- 2012/10/12 06:00 [entrez]
PHST- 2010/12/01 00:00 [pubmed]
PHST- 2010/12/01 00:01 [medline]
AID - S1876-2018(10)00119-X [pii]
AID - 10.1016/j.ajp.2010.08.011 [doi]
PST - ppublish
SO  - Asian J Psychiatr. 2010 Dec;3(4):244-8. doi: 10.1016/j.ajp.2010.08.011. Epub 2010
      Nov 18.


PMID- 22810719
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20120719
IS  - 1080-2371 (Print)
IS  - 1080-2371 (Linking)
VI  - 16
IP  - 6 Traumatic Brain Injury
DP  - 2010 Dec
TI  - Ethical perspectives in neurology: sports-acquired traumatic brain injury.
PG  - 161-5
LID - 10.1212/01.CON.0000391462.98911.26 [doi]
FAU - Russo, Michael B
AU  - Russo MB
FAU - Crutchfield, Kevin E
AU  - Crutchfield KE
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Continuum (Minneap Minn)
JT  - Continuum (Minneapolis, Minn.)
JID - 9509333
EDAT- 2010/12/01 00:00
MHDA- 2010/12/01 00:01
CRDT- 2012/07/20 06:00
PHST- 2012/07/20 06:00 [entrez]
PHST- 2010/12/01 00:00 [pubmed]
PHST- 2010/12/01 00:01 [medline]
AID - 10.1212/01.CON.0000391462.98911.26 [doi]
AID - 00132979-201012000-00013 [pii]
PST - ppublish
SO  - Continuum (Minneap Minn). 2010 Dec;16(6 Traumatic Brain Injury):161-5. doi:
      10.1212/01.CON.0000391462.98911.26.


PMID- 22471199
OWN - NLM
STAT- MEDLINE
DCOM- 20120419
LR  - 20120404
IS  - 0019-5138 (Print)
IS  - 0019-5138 (Linking)
VI  - 42
IP  - 4
DP  - 2010 Dec
TI  - Gaps in the knowledge about advancements in rabies vaccines among the
      undergraduate medical students.
PG  - 287-90
AB  - Enormous developments have taken place during the past few years in the field of 
      Rabies prevention and control particularly rabies vaccines. Intra-dermal Rabies
      Vaccination (IDRV) has already emerged as a safe, ethical and cost-effective
      replacement. However appropriate dissemination of knowledge and implementation by
      medical fraternity is imperative for effective prevention and control of this
      fatal disease. Gaps were found in the knowledge of medical students regarding the
      newer rabies vaccines. This can be resolved to great extent by updating the
      undergraduate curriculum with the current control strategies used in this field.
FAU - Laskar, Ananya Ray
AU  - Laskar AR
AD  - Dept. of Community Medicine, Maulana Azad Medical College, New Delhi-110002.
      ananya.ray.laskar@gmail
FAU - Singh, Megha Chandra
AU  - Singh MC
FAU - Saha, S S
AU  - Saha SS
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Commun Dis
JT  - The Journal of communicable diseases
JID - 0261652
RN  - 0 (Rabies Vaccines)
SB  - IM
MH  - Curriculum
MH  - *Education, Medical, Undergraduate
MH  - Humans
MH  - *Knowledge
MH  - Rabies Vaccines/*immunology
MH  - *Students, Medical
EDAT- 2010/12/01 00:00
MHDA- 2012/04/20 06:00
CRDT- 2012/04/05 06:00
PHST- 2012/04/05 06:00 [entrez]
PHST- 2010/12/01 00:00 [pubmed]
PHST- 2012/04/20 06:00 [medline]
PST - ppublish
SO  - J Commun Dis. 2010 Dec;42(4):287-90.


PMID- 22460301
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1868-6001 (Electronic)
IS  - 1868-310X (Linking)
VI  - 1
IP  - 4
DP  - 2010 Dec
TI  - Points to consider in assessing and appraising predictive genetic tests.
PG  - 185-94
LID - 10.1007/s12687-010-0028-7 [doi]
AB  - The use of predictive genetic tests is expanding rapidly. Given limited health
      care budgets and few national coverage decisions specifically for genetic tests, 
      evidence of benefits and harms is a key requirement in decision making; however, 
      assessing the benefits and harms of genetic tests raises a number of challenging 
      issues. Frequently, evidence of medical benefits and harms is limited due to
      practical and ethical limitations of conducting meaningful clinical trials. Also,
      clinical endpoints frequently do not capture the benefit appropriately because
      the main purpose of many genetic tests is personal utility of knowing the test
      results, and costs of the tests and counseling can be insufficient indicators of 
      the total costs of care. This study provides an overview of points to consider
      for the assessment of benefits and harms from genetic tests in an ethically and
      economically reflected manner. We discuss whether genetic tests are sufficiently 
      exceptional to warrant exceptional methods for assessment and appraisal.
FAU - Rogowski, Wolf H
AU  - Rogowski WH
AD  - Helmholtz Zentrum Munchen, German Research Center for Environmental Health
      (GmbH), Ingolstadter Landstrasse 1, 85764, Neuherberg, Germany,
      rogowski@helmholtz-muenchen.de.
FAU - Grosse, Scott D
AU  - Grosse SD
FAU - John, Jurgen
AU  - John J
FAU - Kaariainen, Helena
AU  - Kaariainen H
FAU - Kent, Alastair
AU  - Kent A
FAU - Kristofferson, Ulf
AU  - Kristofferson U
FAU - Schmidtke, Jorg
AU  - Schmidtke J
LA  - eng
PT  - Journal Article
DEP - 20101016
PL  - Germany
TA  - J Community Genet
JT  - Journal of community genetics
JID - 101551501
PMC - PMC3186003
EDAT- 2010/12/01 00:00
MHDA- 2010/12/01 00:01
CRDT- 2012/03/31 06:00
PHST- 2010/08/03 00:00 [received]
PHST- 2010/10/01 00:00 [accepted]
PHST- 2012/03/31 06:00 [entrez]
PHST- 2010/12/01 00:00 [pubmed]
PHST- 2010/12/01 00:01 [medline]
AID - 10.1007/s12687-010-0028-7 [doi]
PST - ppublish
SO  - J Community Genet. 2010 Dec;1(4):185-94. doi: 10.1007/s12687-010-0028-7. Epub
      2010 Oct 16.


PMID- 21113208
OWN - NLM
STAT- MEDLINE
DCOM- 20110120
LR  - 20101129
IS  - 0211-6995 (Print)
IS  - 0211-6995 (Linking)
VI  - 30
IP  - 6
DP  - 2010
TI  - [Reinventing specialty training of physicians? Principles and challenges].
PG  - 604-12
LID - 10.3265/Nefrologia.pre2010.Jul.10559 [doi]
AB  - In a world undergoing constant change, in the era of globalisation, the training 
      of medical professionals should be under constant review so that it can be
      tailored to meet the needs of this society in transition. This is all the more
      true at times of economic uncertainty, such as the current conditions, which have
      a direct impact on health services. Professionals need new Competencies for new
      times. Over the last decade initiatives have emerged in various Anglo-Saxon
      countries which have defined a framework of basic Competencies that all medical
      specialists should demonstrate in their professional practice. In addition to
      this, we must respond to the creation of the European Higher Education Area which
      has implications for specialised training. In Spain, training for medical
      specialists was in need of an overhaul and the recently passed law (Real Decreto 
      183/2008) will allow us to move forward and implement, in medical education,
      initiatives and innovations required in our medical centres, to respond to the
      new society and bring us in line with international professional education and
      practice. The way forward is a Competency-based model for medical education with 
      assessment of these Competencies using simple instruments, validated and accepted
      by all the stakeholders. The institutions involved (hospitals, medical centres
      and other health care services) should trial different approaches within the
      general framework established by the current legislation and be conscious of the 
      duty they have to society as accredited training organisations. Accordingly, they
      should consolidate their teaching and learning structures and the various
      different educational roles (Director of Studies, Tutors, and other teaching
      positions), showing the leadership necessary to allow proper implementation of
      their training programmes. For this, the Spanish Autonomous Regions must develop 
      their own legislation regulating Medical Specialty Training. So, medical
      professionals should receive training, based on ethical values, behaviours and
      attitudes that considers humanistic, scientific and technical factors, developing
      an understanding of the scientific method; ability to put it into practice;
      skills to manage complexity and uncertainty; a command of scientific, technical
      and IT terminology to facilitate independent learning; and a capacity for
      initiative and teamwork, as well as skills for dealing with people and for making
      an effective, democratic contribution both within health organisations and in the
      wider society.
FAU - Moran-Barrios, J
AU  - Moran-Barrios J
AD  - Unidad de Docencia Medica, Hospital de Cruces, Osakidetza-Servicio Vasco de
      Salud, Baracaldo, Vizcaya. jesusmanuel.moranbarrios@osakidetza.net
FAU - Ruiz de Gauna Bahillo, P
AU  - Ruiz de Gauna Bahillo P
CN  - Miembros de la Junta Directiva de la Sociedad de Educacion Medica de Euskadi
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - inverted question markReinventar la formacion de medicos especialistas?
      Principios y retos.
PL  - Spain
TA  - Nefrologia
JT  - Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia
JID - 8301215
SB  - IM
MH  - *Clinical Competence
MH  - Curriculum
MH  - Education, Medical, Graduate/legislation & jurisprudence/*methods/trends
MH  - Educational Measurement
MH  - Europe
MH  - Health Services Needs and Demand
MH  - Humans
MH  - Inservice Training
MH  - Internship and Residency/standards/trends
MH  - *Medicine/standards
MH  - Models, Theoretical
MH  - Nephrology/education/standards
MH  - Social Change
MH  - Spain
EDAT- 2010/11/30 06:00
MHDA- 2011/01/21 06:00
CRDT- 2010/11/30 06:00
PHST- 2010/07/22 00:00 [accepted]
PHST- 2010/11/30 06:00 [entrez]
PHST- 2010/11/30 06:00 [pubmed]
PHST- 2011/01/21 06:00 [medline]
AID - 10.3265/Nefrologia.pre2010.Jul.10559 [doi]
PST - ppublish
SO  - Nefrologia. 2010;30(6):604-12. doi: 10.3265/Nefrologia.pre2010.Jul.10559.


PMID- 21112941
OWN - NLM
STAT- MEDLINE
DCOM- 20110315
LR  - 20161125
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 12
DP  - 2010 Dec
TI  - The ethics of screening for abdominal aortic aneurysm in men.
PG  - 827-30
LID - 10.1136/jme.2010.035519 [doi]
AB  - Approximately 6000 men die every year from ruptured abdominal aortic aneurysm in 
      England and Wales. Randomised clinical trials and a large pilot study have shown 
      that ultrasound screening of men aged 65&emsp14;years can prevent about half of
      these deaths. However, there is a significant perioperative morbidity and
      mortality from interventions to repair the detected aneurysm. This paper explores
      the ethical issues of screening men for abdominal aortic aneurysm. It is
      concluded that a population screening programme for abdominal aortic aneurysm
      offers a clear balance of good over harm. It is therefore ethically justified, as
      long as men are given adequate information at every stage of the process. Each
      man has the right to be properly informed, regardless of whether he accepts the
      invitation to be screened and, if an aneurysm is detected, whether or not he
      accepts treatment.
FAU - Brownsword, Roger
AU  - Brownsword R
AD  - Centre for Technology, Law, Ethics and Society (TELOS), King's College, London,
      UK.
FAU - Earnshaw, Jonothan J
AU  - Earnshaw JJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Aged
MH  - Aortic Aneurysm, Abdominal/*diagnosis/mortality
MH  - *Ethics, Medical
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Male
MH  - Mass Screening/*ethics
MH  - United Kingdom/epidemiology
EDAT- 2010/11/30 06:00
MHDA- 2011/03/16 06:00
CRDT- 2010/11/30 06:00
PHST- 2010/11/30 06:00 [entrez]
PHST- 2010/11/30 06:00 [pubmed]
PHST- 2011/03/16 06:00 [medline]
AID - 36/12/827 [pii]
AID - 10.1136/jme.2010.035519 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Dec;36(12):827-30. doi: 10.1136/jme.2010.035519.


PMID- 21112940
OWN - NLM
STAT- MEDLINE
DCOM- 20110315
LR  - 20211020
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 12
DP  - 2010 Dec
TI  - Developing ethics guidance for HIV prevention research: the HIV Prevention Trials
      Network approach.
PG  - 810-5
LID - 10.1136/jme.2010.035444 [doi]
AB  - More than 25&emsp14;years into the HIV epidemic, in excess of 2 million new
      infections continue to occur each year. HIV prevention research is crucial for
      groups at heightened risk for HIV, but the design and conduct of HIV prevention
      research with vulnerable populations worldwide raises considerable ethical
      challenges. The HIV Prevention Trials Network (HPTN) is a global collaborative
      network that conducts clinical and behavioural studies on non-vaccine
      interventions to reduce the transmission of HIV. In 2003, the HPTN developed
      ethical guidance to enhance the responsible conduct of its research activities
      and as a distinctive contribution to global research ethics. In what follows, the
      developments that motivated the drafting of a revised ethics document in 2009 are
      described, including the process by which that revision took place and some of
      the key differences between the HPTN ethics guidance and other relevant
      guidelines in the field.
FAU - Rennie, Stuart
AU  - Rennie S
AD  - Department of Social Medicine, University of North Carolina, Chapel Hill, North
      Carolina, USA.
FAU - Sugarman, Jeremy
AU  - Sugarman J
LA  - eng
GR  - U01 AI068619/AI/NIAID NIH HHS/United States
GR  - U01 AI068619-04/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Clinical Trials as Topic/*ethics/standards
MH  - *Ethics, Research
MH  - HIV Infections/*prevention & control
MH  - Human Experimentation/ethics
MH  - Humans
MH  - *Practice Guidelines as Topic
PMC - PMC3129851
MID - NIHMS299120
EDAT- 2010/11/30 06:00
MHDA- 2011/03/16 06:00
CRDT- 2010/11/30 06:00
PHST- 2010/11/30 06:00 [entrez]
PHST- 2010/11/30 06:00 [pubmed]
PHST- 2011/03/16 06:00 [medline]
AID - 36/12/810 [pii]
AID - 10.1136/jme.2010.035444 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Dec;36(12):810-5. doi: 10.1136/jme.2010.035444.


PMID- 21112939
OWN - NLM
STAT- MEDLINE
DCOM- 20110315
LR  - 20101129
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 12
DP  - 2010 Dec
TI  - HIV/AIDS and circumcision: lost in translation.
PG  - 798-801
LID - 10.1136/jme.2010.038695 [doi]
AB  - In April 2009 a Cochrane review was published assessing the effectiveness of male
      circumcision in preventing acquisition of HIV. It concluded that there was strong
      evidence that male circumcision, performed in a medical setting, reduces the
      acquisition of HIV by men engaging in heterosexual sex. Yet, importantly, the
      review noted that further research was required to assess the feasibility,
      desirability and cost-effectiveness of implementation within local contexts. This
      paper endorses the need for such research and suggests that, in its absence, it
      is premature to promote circumcision as a reliable strategy for combating HIV.
      Since articles in leading medical journals as well as the popular press continue 
      to do so, scientific researchers should think carefully about how their
      conclusions may be translated both to policy makers and to a more general
      audience. The importance of addressing ethico-legal concerns that such trials may
      raise is highlighted. The understandable haste to find a solution to the HIV
      pandemic means that the promise offered by preliminary and specific research
      studies may be overstated. This may mean that ethical concerns are marginalized. 
      Such haste may also obscure the need to be attentive to local cultural
      sensitivities, which vary from one African region to another, in formulating
      policy concerning circumcision.
FAU - Fox, Marie
AU  - Fox M
AD  - School of Law, Keele University, Staffordshire ST5 5BG, UK. m.fox@law.keele.ac.uk
FAU - Thomson, Michael
AU  - Thomson M
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Africa
MH  - *Circumcision, Male/ethics
MH  - HIV Infections/*prevention & control/transmission
MH  - *Heterosexuality
MH  - Humans
MH  - Male
MH  - Review Literature as Topic
EDAT- 2010/11/30 06:00
MHDA- 2011/03/16 06:00
CRDT- 2010/11/30 06:00
PHST- 2010/11/30 06:00 [entrez]
PHST- 2010/11/30 06:00 [pubmed]
PHST- 2011/03/16 06:00 [medline]
AID - 36/12/798 [pii]
AID - 10.1136/jme.2010.038695 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Dec;36(12):798-801. doi: 10.1136/jme.2010.038695.


PMID- 21112937
OWN - NLM
STAT- MEDLINE
DCOM- 20110315
LR  - 20161125
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 12
DP  - 2010 Dec
TI  - Legal and ethical implications of inherited cardiac disease in clinical practice 
      within the UK.
PG  - 762-6
LID - 10.1136/jme.2009.034108 [doi]
AB  - Increasing genetic knowledge over the last decade has enabled hundreds of genetic
      variants associated with inherited cardiac conditions to be identified, many of
      which cause increased risk of sudden cardiac death. While individually these
      conditions are rare, taken together they impose a significant burden. The
      severity of these conditions--the possibility that they might cause sudden
      unheralded death of a teenager or young adult--juxtaposed with uncertainty about 
      the pathology linked with many of the genetic variants is significant in terms of
      professional practice because, increasingly, clinicians have been encouraged to
      cascade out genetic testing from the proband or consultand to other family
      members who may be at risk of developing the same condition. This process often
      involves sharing human tissue samples, DNA or personal information. This paper
      reviews the legal and regulatory frameworks which may apply when tissue and DNA
      samples are collected, used and retained, both for the purpose of diagnosis and
      for benefiting other family members, when a suspected or definitive diagnosis of 
      an inherited cardiovascular condition is made. Sometimes the interests of family 
      members may conflict, and it may be difficult for practitioners to reconcile the 
      interests of one family member with another, particularly if the balance of
      benefits and harms from testing is unclear. The paper then examines some of the
      ethical tensions which may arise in practice and concludes that all involved
      should be conversant with the legal and ethical frameworks that apply.
FAU - Hall, Alison E
AU  - Hall AE
AD  - PHG Foundation, 2 Worts Causeway, Cambridge CB1 8RN, UK.
      alison.hall@phgfoundation.org
FAU - Burton, Hilary
AU  - Burton H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Disclosure/*ethics
MH  - *Ethics, Medical
MH  - Genetic Counseling
MH  - *Genetic Diseases, Inborn/diagnosis/genetics
MH  - *Genetic Predisposition to Disease
MH  - Genetic Testing/*ethics/legislation & jurisprudence
MH  - Heart Diseases/diagnosis/*genetics
MH  - Humans
MH  - Tissue Preservation/ethics
MH  - Tissue and Organ Procurement/legislation & jurisprudence
MH  - United Kingdom
EDAT- 2010/11/30 06:00
MHDA- 2011/03/16 06:00
CRDT- 2010/11/30 06:00
PHST- 2010/11/30 06:00 [entrez]
PHST- 2010/11/30 06:00 [pubmed]
PHST- 2011/03/16 06:00 [medline]
AID - 36/12/762 [pii]
AID - 10.1136/jme.2009.034108 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Dec;36(12):762-6. doi: 10.1136/jme.2009.034108.


PMID- 21112935
OWN - NLM
STAT- MEDLINE
DCOM- 20110315
LR  - 20111123
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 12
DP  - 2010 Dec
TI  - Implementing clinical ethics in German hospitals: content, didactics and
      evaluation of a nationwide postgraduate training programme.
PG  - 721-6
LID - 10.1136/jme.2010.036137 [doi]
AB  - The Hannover qualifying programme 'ethics consultation in hospitals', conducted
      by a four-institution cooperation partnership, is an interdisciplinary,
      scientifically based programme for healthcare professionals interested in ethics 
      consultation services and is widely acknowledged by hospital managements and
      healthcare professionals. It is unique concerning its content, scope and teaching
      format. With its basic and advanced modules it has provided training and
      education for 367 healthcare professionals with 570 participations since 2003
      (until February 2010). One characteristic feature is its attractiveness for
      health professionals from different backgrounds. Internationally, the Hannover
      programme is one of the few schedules with both academics and non-academics as
      target groups and a high participation rate of physicians. The concept of the
      Hannover programme is in great demand, and its schedule is continuously optimised
      through evaluation. The goals of enabling healthcare professionals from different
      professional backgrounds to define and reflect ethical problems, to facilitate
      and support the process of decision-making and to work out structures for their
      own institutions seem to have been achieved. However, in order to obtain
      effective and sustainable results, participation in the programme should be
      supplemented regularly by in-house training sessions or individual expert
      consultations. Future challenges include new thematic courses and providing a
      network for former participants, especially when they come from non-academic
      hospitals. The network is a reasonable platform to discuss participants'
      experiences, successes and pitfalls. A further task will be research on how the
      programme's concept can support the sustainability of ethics structures in the
      various institutions.
FAU - Dorries, Andrea
AU  - Dorries A
AD  - Zentrum fur Gesundheitsethik (ZfG), Knochenhauerstrasse 33, 30159 Hannover,
      Germany. andrea.doerries@evlka.de
FAU - Simon, Alfred
AU  - Simon A
FAU - Neitzke, Gerald
AU  - Neitzke G
FAU - Vollmann, Jochen
AU  - Vollmann J
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
CIN - Indian J Med Ethics. 2011 Apr-Jun;8(2):117-9. PMID: 22106624
MH  - Curriculum/*standards
MH  - Education, Medical, Graduate/*methods/*standards
MH  - Ethics, Medical/*education
MH  - Germany
MH  - Hospitals
MH  - Humans
MH  - Program Evaluation
EDAT- 2010/11/30 06:00
MHDA- 2011/03/16 06:00
CRDT- 2010/11/30 06:00
PHST- 2010/11/30 06:00 [entrez]
PHST- 2010/11/30 06:00 [pubmed]
PHST- 2011/03/16 06:00 [medline]
AID - 36/12/721 [pii]
AID - 10.1136/jme.2010.036137 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Dec;36(12):721-6. doi: 10.1136/jme.2010.036137.


PMID- 21112672
OWN - NLM
STAT- MEDLINE
DCOM- 20110223
LR  - 20110117
IS  - 1097-6787 (Electronic)
IS  - 0190-9622 (Linking)
VI  - 64
IP  - 2
DP  - 2011 Feb
TI  - Why a new section dedicated to ethics in the JAAD?
PG  - 432-3
LID - 10.1016/j.jaad.2010.11.002 [doi]
FAU - Grant-Kels, Jane M
AU  - Grant-Kels JM
AD  - Department of Dermatology, University of Connecticut Health Center, Farmington,
      CT, USA.
FAU - Bercovitch, Lionel
AU  - Bercovitch L
LA  - eng
PT  - Journal Article
DEP - 20101126
PL  - United States
TA  - J Am Acad Dermatol
JT  - Journal of the American Academy of Dermatology
JID - 7907132
SB  - IM
MH  - Conflict of Interest
MH  - Dermatology/*ethics
MH  - Humans
MH  - Periodicals as Topic
MH  - *Skin Diseases
EDAT- 2010/11/30 06:00
MHDA- 2011/02/24 06:00
CRDT- 2010/11/30 06:00
PHST- 2010/10/26 00:00 [received]
PHST- 2010/10/27 00:00 [revised]
PHST- 2010/11/01 00:00 [accepted]
PHST- 2010/11/30 06:00 [entrez]
PHST- 2010/11/30 06:00 [pubmed]
PHST- 2011/02/24 06:00 [medline]
AID - S0190-9622(10)02021-9 [pii]
AID - 10.1016/j.jaad.2010.11.002 [doi]
PST - ppublish
SO  - J Am Acad Dermatol. 2011 Feb;64(2):432-3. doi: 10.1016/j.jaad.2010.11.002. Epub
      2010 Nov 26.


PMID- 21112540
OWN - NLM
STAT- MEDLINE
DCOM- 20110328
LR  - 20161125
IS  - 1472-6491 (Electronic)
IS  - 1472-6483 (Linking)
VI  - 21
IP  - 7
DP  - 2010 Dec
TI  - Beyond the 'embryo question': human embryonic stem cell ethics in the context of 
      biomaterial donation in the UK.
PG  - 868-74
LID - 10.1016/j.rbmo.2010.10.001 [doi]
AB  - Discussion about the ethics of human embryonic stem cell (ESC) research in the UK
      tends to be dominated by the divisive and potentially intractable issue of the
      moral status of the embryo. This can have the effect of silencing or
      marginalizing other concerns, especially in the context of public engagement with
      science in this field. One such area of potential public concern is the donation 
      of oocytes and embryos to stem cell research. Contemporary research on the views 
      of donors and potential donors about a wide range of biomaterials, from solid
      organs to gametes and bone marrow, is reviewed and used to illustrate the range
      and types of ethical concerns articulated by this important group of
      stakeholders. Attitudes to donation are found to vary according to the type of
      tissue being donated or collected, the purpose for which donation is being sought
      and the nature of the recipient of the donation. Pertinently, attitudes towards
      donating oocytes are found to differ in some respects from donation of embryos or
      fetal tissue. The implications of these findings for ensuring ethically robust
      informed consent and publicly acceptable sourcing of human biomaterials for stem 
      cell research are then considered.
CI  - Copyright (c) 2010 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All
      rights reserved.
FAU - Bahadur, G
AU  - Bahadur G
AD  - Fertility Unit, North Middlesex University Hospital NHS Trust, Stirling Way,
      London N18 1QX, UK. bahadur.g@gmail.com
FAU - Morrison, M
AU  - Morrison M
FAU - Machin, L
AU  - Machin L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
SB  - IM
MH  - *Bioethical Issues
MH  - *Embryo, Mammalian
MH  - *Embryonic Stem Cells
MH  - Female
MH  - Government Regulation
MH  - Humans
MH  - Living Donors/psychology
MH  - Male
MH  - Morals
MH  - Motivation
MH  - Oocyte Donation/ethics/psychology
MH  - Public Policy
MH  - Stem Cell Research/*ethics/legislation & jurisprudence
MH  - Tissue and Organ Procurement/*ethics/legislation & jurisprudence
MH  - Transplantation/ethics/legislation & jurisprudence/psychology
MH  - United Kingdom
EDAT- 2010/11/30 06:00
MHDA- 2011/03/29 06:00
CRDT- 2010/11/30 06:00
PHST- 2010/07/21 00:00 [received]
PHST- 2010/09/30 00:00 [revised]
PHST- 2010/10/05 00:00 [accepted]
PHST- 2010/11/30 06:00 [entrez]
PHST- 2010/11/30 06:00 [pubmed]
PHST- 2011/03/29 06:00 [medline]
AID - S1472-6483(10)00639-5 [pii]
AID - 10.1016/j.rbmo.2010.10.001 [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2010 Dec;21(7):868-74. doi: 10.1016/j.rbmo.2010.10.001.


PMID- 21111834
OWN - NLM
STAT- MEDLINE
DCOM- 20110513
LR  - 20110131
IS  - 1095-9572 (Electronic)
IS  - 1053-8119 (Linking)
VI  - 55
IP  - 1
DP  - 2011 Mar 1
TI  - Lying in the scanner: covert countermeasures disrupt deception detection by
      functional magnetic resonance imaging.
PG  - 312-9
LID - 10.1016/j.neuroimage.2010.11.025 [doi]
AB  - Functional magnetic resonance imaging (fMRI) studies have documented differences 
      between deceptive and honest responses. Capitalizing on this research, companies 
      marketing fMRI-based lie detection services have been founded, generating
      methodological and ethical concerns in scientific and legal communities.
      Critically, no fMRI study has examined directly the effect of countermeasures,
      methods used by prevaricators to defeat deception detection procedures. An fMRI
      study was conducted to fill this research gap using a concealed information
      paradigm in which participants were trained to use countermeasures. Robust group 
      fMRI differences between deceptive and honest responses were found without, but
      not with countermeasures. Furthermore, in single participants, deception
      detection accuracy was 100% without countermeasures, using activation in
      ventrolateral and medial prefrontal cortices, but fell to 33% with
      countermeasures. These findings show that fMRI-based deception detection measures
      can be vulnerable to countermeasures, calling for caution before applying these
      methods to real-world situations.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Ganis, Giorgio
AU  - Ganis G
AD  - Department of Radiology, Harvard Medical School, Boston, MA 02115, USA.
      ganis@nmr.mgh.harvard.edu
FAU - Rosenfeld, J Peter
AU  - Rosenfeld JP
FAU - Meixner, John
AU  - Meixner J
FAU - Kievit, Rogier A
AU  - Kievit RA
FAU - Schendan, Haline E
AU  - Schendan HE
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20101124
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
SB  - IM
MH  - Brain/*physiology
MH  - Brain Mapping/*methods
MH  - *Deception
MH  - Evoked Potentials/*physiology
MH  - Female
MH  - Humans
MH  - *Lie Detection
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - *Truth Disclosure
MH  - Young Adult
EDAT- 2010/11/30 06:00
MHDA- 2011/05/14 06:00
CRDT- 2010/11/30 06:00
PHST- 2010/09/07 00:00 [received]
PHST- 2010/10/27 00:00 [revised]
PHST- 2010/11/05 00:00 [accepted]
PHST- 2010/11/30 06:00 [entrez]
PHST- 2010/11/30 06:00 [pubmed]
PHST- 2011/05/14 06:00 [medline]
AID - S1053-8119(10)01455-2 [pii]
AID - 10.1016/j.neuroimage.2010.11.025 [doi]
PST - ppublish
SO  - Neuroimage. 2011 Mar 1;55(1):312-9. doi: 10.1016/j.neuroimage.2010.11.025. Epub
      2010 Nov 24.


PMID- 21111356
OWN - NLM
STAT- MEDLINE
DCOM- 20110502
LR  - 20181201
IS  - 1460-9576 (Electronic)
IS  - 0968-8080 (Linking)
VI  - 18
IP  - 36
DP  - 2010 Nov
TI  - Obstacles and challenges following the partial decriminalisation of abortion in
      Colombia.
PG  - 118-26
LID - 10.1016/S0968-8080(10)36531-1 [doi]
AB  - During a highly contested process, abortion was partially decriminalised in
      Colombia in 2006 by the Constitutional Court: when the pregnancy threatens a
      woman's life or health, in cases of severe fetal malformations incompatible with 
      life, and in cases of rape, incest or unwanted insemination. However, Colombian
      women still face obstacles to accessing abortion services. This is illustrated by
      36 cases of women who in 2006-08 were denied the right to a lawful termination of
      pregnancy, or had unjustified obstacles put in their path which delayed the
      termination, which are analysed in this article. We argue that the obstacles
      resulted from fundamental disagreements about abortion and misunderstandings
      regarding the ethical, legal and medical requirements arising from the Court's
      decision. In order to avoid obstacles such as demands for a judge's
      authorisation, institutional claims of conscientious objection, rejection of a
      claim of rape, or refusal of health insurance coverage for a legal termination,
      which constitute discrimination against women, three main strategies are
      suggested: public ownership of the Court's decision by all Colombian citizens, a 
      professional approach by those involved in the provision of services in line with
      the law, and monitoring of its implementation by governmental and
      non-governmental organisations.
CI  - Copyright (c) 2010 Reproductive Health Matters. Published by Elsevier Ltd. All
      rights reserved.
FAU - Amado, Eduardo Diaz
AU  - Amado ED
AD  - Department of Philosophy & Centre for the History of Medicine and Disease, Durham
      University, Durham, UK. eduardo.diaz-amado@durham.ac.uk
FAU - Calderon Garcia, Maria Cristina
AU  - Calderon Garcia MC
FAU - Cristancho, Katherine Romero
AU  - Cristancho KR
FAU - Salas, Elena Prada
AU  - Salas EP
FAU - Hauzeur, Eliane Barreto
AU  - Hauzeur EB
LA  - eng
PT  - Journal Article
PL  - England
TA  - Reprod Health Matters
JT  - Reproductive health matters
JID - 9420826
SB  - IM
MH  - Abortion, Induced/*legislation & jurisprudence
MH  - Abortion, Legal/statistics & numerical data
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Colombia
MH  - Crime/*legislation & jurisprudence
MH  - Female
MH  - Health Services Accessibility/*legislation & jurisprudence
MH  - Human Rights/legislation & jurisprudence
MH  - Humans
MH  - Pregnancy
MH  - Young Adult
EDAT- 2010/11/30 06:00
MHDA- 2011/05/03 06:00
CRDT- 2010/11/30 06:00
PHST- 2010/11/30 06:00 [entrez]
PHST- 2010/11/30 06:00 [pubmed]
PHST- 2011/05/03 06:00 [medline]
AID - S0968-8080(10)36531-1 [pii]
AID - 10.1016/S0968-8080(10)36531-1 [doi]
PST - ppublish
SO  - Reprod Health Matters. 2010 Nov;18(36):118-26. doi:
      10.1016/S0968-8080(10)36531-1.


PMID- 21109801
OWN - NLM
STAT- MEDLINE
DCOM- 20110330
LR  - 20191210
IS  - 1476-5373 (Electronic)
IS  - 0007-0610 (Linking)
VI  - 209
IP  - 10
DP  - 2010 Nov 27
TI  - Unethical aspects of homeopathic dentistry.
PG  - 493-6
LID - 10.1038/sj.bdj.2010.1032 [doi]
AB  - In the last year there has been a great deal of public debate about homeopathy,
      the system of alternative medicine whose main principles are that like cures like
      and that potency increases relative to dilution. The House of Commons Select
      Committee on Science and Technology concluded in November 2009 that there is no
      evidence base for homeopathy, and agreed with some academic commentators that
      homeopathy should not be funded by the NHS. While homeopathic doctors and
      hospitals are quite commonplace, some might be surprised to learn that there are 
      also many homeopathic dentists practising in the UK. This paper examines the
      statements made by several organisations on behalf of homeopathic dentistry and
      suggests that they are not entirely ethical and may be in breach of various
      professional guidelines.
FAU - Shaw, D
AU  - Shaw D
AD  - Dental School, Faculty of Medicine, University of Glasgow, 378 Sauchiehall
      Street, Glasgow, G2 3JZ. david.shaw@.glasgow.ac.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br Dent J
JT  - British dental journal
JID - 7513219
RN  - 0 (Materia Medica)
RN  - 0 (Plant Preparations)
SB  - IM
CIN - Br Dent J. 2011 Mar 12;210(5):198. PMID: 21394129
CIN - Br Dent J. 2011 Apr 9;210(7):291-2. PMID: 21475257
CIN - Br Dent J. 2011 Apr 9;210(7):292. PMID: 21475261
CIN - Br Dent J. 2011 Jun;210(12):557-8. PMID: 21701449
CIN - Br Dent J. 2011 Jun;210(12):557. PMID: 21701450
MH  - Advertising/ethics
MH  - Dentists/*ethics
MH  - *Ethics, Dental
MH  - Homeopathy/*ethics
MH  - Humans
MH  - Materia Medica/therapeutic use
MH  - Mouth Diseases/drug therapy
MH  - Phytotherapy
MH  - Plant Preparations/therapeutic use
MH  - Societies, Dental
MH  - Tooth Diseases/drug therapy
MH  - United Kingdom
EDAT- 2010/11/27 06:00
MHDA- 2011/03/31 06:00
CRDT- 2010/11/27 06:00
PHST- 2010/10/07 00:00 [accepted]
PHST- 2010/11/27 06:00 [entrez]
PHST- 2010/11/27 06:00 [pubmed]
PHST- 2011/03/31 06:00 [medline]
AID - sj.bdj.2010.1032 [pii]
AID - 10.1038/sj.bdj.2010.1032 [doi]
PST - ppublish
SO  - Br Dent J. 2010 Nov 27;209(10):493-6. doi: 10.1038/sj.bdj.2010.1032.


PMID- 21109699
OWN - NLM
STAT- MEDLINE
DCOM- 20110519
LR  - 20110217
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 3
DP  - 2011 Mar
TI  - Ethical review reporting of Chinese trials records in WHO primary registries.
PG  - 144-8
LID - 10.1136/jme.2010.036558 [doi]
AB  - OBJECTIVE: To investigate the report rate of ethical review in registered Chinese
      trials records. METHODS: Chinese trials recorded in WHO primary registries and
      http://clinicaltrials.gov to 14 July 2009 were identified. The report rates of
      ethical review and each of the 20 items in WHO's Trial Registration Data Set were
      calculated. Correlation of the item's report rate with the ethical review report 
      rate was assessed. PubMed, EMBASE, CNKI and CBM (from the establishment of each
      database to 14 July 2009) were also searched to collect the full texts of
      completed trials to calculate the report rate of ethical review in the result
      publications. RESULTS: A total of 1247 records were identified, and 687 (55.1%)
      reported ethical review. The records reporting secondary sponsor(s), contact for 
      public queries and key secondary outcomes were more likely to report ethical
      review information (66.3% vs 44.3%, 38.1% vs 28.5%, 53.9% vs 51.8%). The ethical 
      review report rate of trials sponsored by industry was lower than those sponsored
      by non-industry (40.9% vs 51.9%). The report rates of ethical review for
      self-supported trials (83.5%) and trials with unidentified sources of monetary or
      material support (66.7%) were lower than the average ethical review report rate
      for records in the Chinese Clinical Trial Registration Center (ChiCTR). The
      ethical review report rate was not high in the result publications (84.3% in
      http://clinicaltrials.gov, 50.0% in ChiCTR). CONCLUSION: Registered Chinese
      trials records report ethical review inadequately. Incomplete registration is
      correlated with not reporting ethical review. Medical journals should inspect
      ethical review more critically.
FAU - Xuemei, Liu
AU  - Xuemei L
AD  - Chinese Evidence-Based Medicine Center, West China Hospital of Sichuan
      University, Chengdu 610041, China.
FAU - Youping, Li
AU  - Youping L
FAU - Shangqi, Song
AU  - Shangqi S
FAU - Senlin, Yin
AU  - Senlin Y
FAU - Williams, Shawna
AU  - Williams S
LA  - eng
PT  - Journal Article
DEP - 20101125
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - China
MH  - Clinical Trials as Topic/*ethics/standards
MH  - Ethical Review/*standards
MH  - Humans
MH  - Publishing/standards
MH  - *Research Design
MH  - World Health Organization
EDAT- 2010/11/27 06:00
MHDA- 2011/05/20 06:00
CRDT- 2010/11/27 06:00
PHST- 2010/11/27 06:00 [entrez]
PHST- 2010/11/27 06:00 [pubmed]
PHST- 2011/05/20 06:00 [medline]
AID - jme.2010.036558 [pii]
AID - 10.1136/jme.2010.036558 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Mar;37(3):144-8. doi: 10.1136/jme.2010.036558. Epub 2010 Nov
      25.


PMID- 21109698
OWN - NLM
STAT- MEDLINE
DCOM- 20110506
LR  - 20110124
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 2
DP  - 2011 Feb
TI  - Theoretical resources for a globalised bioethics.
PG  - 92-6
LID - 10.1136/jme.2010.036830 [doi]
AB  - In an age of global capitalism, pandemics, far-flung biobanks, multinational drug
      trials and telemedicine it is impossible for bioethicists to ignore the global
      dimensions of their field. However, if they are to do good work on the issues
      that globalisation requires of them, they need theoretical resources that are up 
      to the task. This paper identifies four distinct understandings of 'globalised'
      in the bioethics literature: (1) a focus on global issues; (2) an attempt to
      develop a universal ethical theory that can transcend cultural differences; (3)
      an awareness of how bioethics itself has expanded, with new centres and journals 
      emerging in nearly every corner of the globe; (4) a concern to avoid cultural
      imperialism in encounters with other societies. Each of these approaches to
      globalisation has some merit, as will be shown. The difficulty with them is that 
      the standard theoretical tools on which they rely are not designed for
      cross-cultural ethical reflection. As a result, they leave important
      considerations hidden. A set of theoretical resources is proposed to deal with
      the moral puzzles of globalisation. Abandoning idealised moral theory, a
      normative framework is developed that is sensitive enough to account for
      differences without losing the broader context in which ethical issues arise. An 
      empirically nourished, self-reflexive, socially inquisitive, politically critical
      and inclusive ethics allows bioethicists the flexibility they need to pick up on 
      the morally relevant particulars of this situation here without losing sight of
      the broader cultural contexts in which it all takes place.
FAU - Verkerk, Marian A
AU  - Verkerk MA
AD  - University Medical Center Groningen, University of Groningen, Postbus 30001, 9700
      RB Groningen, The Netherlands. m.a.verkerk@med.umcg.nl
FAU - Lindemann, Hilde
AU  - Lindemann H
LA  - eng
PT  - Journal Article
DEP - 20101125
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Bioethics
MH  - Cultural Characteristics
MH  - Cultural Diversity
MH  - Ethical Analysis/*methods
MH  - *Ethical Theory
MH  - Ethicists/*psychology
MH  - Female
MH  - Humans
MH  - *Internationality
MH  - Male
EDAT- 2010/11/27 06:00
MHDA- 2011/05/07 06:00
CRDT- 2010/11/27 06:00
PHST- 2010/11/27 06:00 [entrez]
PHST- 2010/11/27 06:00 [pubmed]
PHST- 2011/05/07 06:00 [medline]
AID - jme.2010.036830 [pii]
AID - 10.1136/jme.2010.036830 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Feb;37(2):92-6. doi: 10.1136/jme.2010.036830. Epub 2010 Nov
      25.


PMID- 21109581
OWN - NLM
STAT- MEDLINE
DCOM- 20110405
LR  - 20101208
IS  - 1740-7753 (Electronic)
IS  - 1740-7745 (Linking)
VI  - 7
IP  - 6
DP  - 2010 Dec
TI  - Bridging the gap: improving clinical development and the regulatory pathways for 
      health products for neglected diseases.
PG  - 719-34
LID - 10.1177/1740774510386390 [doi]
AB  - BACKGROUND: There has been tremendous progress over the last decade in the
      development of health products--drugs, vaccines, and diagnostics--for neglected
      diseases. There are now dozens of candidate products in the pipeline. PURPOSE:
      Our purpose is to assess challenges that will arise in later-stage clinical
      development of these candidate health products and propose a strategy that would 
      help bring the costs, risks, and finances for their clinical trials into a
      better, more sustainable balance. METHODS: We conducted a literature review of
      clinical trial-related publications, interviewed individuals sponsoring and
      conducting interventional clinical trials for neglected diseases, and analyzed
      data from Clinicaltrials.gov, a clinical trials registry, on neglected disease
      clinical trials initiating subject recruitment between January 1, 2003 and
      December 31, 2009. We quantified Clinicaltrials.gov data into country-specific
      participation in clinical trials and aggregated them into geographic regions. We 
      employed bioinformatics and keyword methods to classify trials by type of
      intervention, sponsor, study phase, and therapeutic area. RESULTS: Two
      substantial bottlenecks threaten our capacity to bring these candidate neglected 
      disease therapies to those in need. First, the research and regulatory capacity
      in many neglected disease-endemic settings is not adequate to support the
      clinical trials that need to occur there in order to complete the development of 
      these products. Second, even with expected attrition in the pipeline, current
      levels of financing are insufficient to support the clinical development of these
      products under current cost assumptions. LIMITATIONS: The proportion of trials of
      relevant studies not registered on Clinicaltrials.gov is not known, but is
      thought to be smaller post-2005, after the International Committee of Medical
      Journal Editors initiated a policy requiring investigators to deposit information
      about trial design into an accepted clinical trials registry before beginning
      patient enrollment. CONCLUSIONS: Realizing the promise of the neglected disease
      product pipeline will require not only increased funding for large-scale clinical
      trials and capacity building, but also greater attention to how these trials and 
      their regulatory pathways can be improved to reduce unnecessary costs, delays,
      and risks to trial subjects. We propose a two-prong strategy: (1) adaptation and 
      adoption of emerging research on 'sensible guidelines' for reducing large-scale, 
      randomized clinical trial costs to the demands of the neglected disease product
      pipeline and (2) regional approaches to regulation and ethical review of clinical
      trials for health products for neglected diseases.
FAU - Bollyky, Thomas J
AU  - Bollyky TJ
AD  - Center for Global Development (CGD), Washington, DC, USA. tbollyky@cgdev.org
FAU - Cockburn, Iain M
AU  - Cockburn IM
FAU - Berndt, Ernst
AU  - Berndt E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20101125
PL  - England
TA  - Clin Trials
JT  - Clinical trials (London, England)
JID - 101197451
RN  - 0 (Vaccines)
SB  - IM
CIN - Clin Trials. 2010 Dec;7(6):621. PMID: 21138919
CIN - Clin Trials. 2010 Dec;7(6):622-5. PMID: 21138920
MH  - Clinical Trials as Topic/*methods/standards/statistics & numerical data
MH  - Computational Biology
MH  - Drug Design
MH  - Drug and Narcotic Control/economics/*methods/statistics & numerical data
MH  - Humans
MH  - Quality of Health Care/legislation & jurisprudence/*standards
MH  - Rare Diseases/diagnosis/*drug therapy/economics
MH  - Registries
MH  - United States
MH  - Vaccines
EDAT- 2010/11/27 06:00
MHDA- 2011/04/06 06:00
CRDT- 2010/11/27 06:00
PHST- 2010/11/27 06:00 [entrez]
PHST- 2010/11/27 06:00 [pubmed]
PHST- 2011/04/06 06:00 [medline]
AID - 1740774510386390 [pii]
AID - 10.1177/1740774510386390 [doi]
PST - ppublish
SO  - Clin Trials. 2010 Dec;7(6):719-34. doi: 10.1177/1740774510386390. Epub 2010 Nov
      25.


PMID- 21109086
OWN - NLM
STAT- MEDLINE
DCOM- 20101230
LR  - 20101126
IS  - 1097-6817 (Electronic)
IS  - 0194-5998 (Linking)
VI  - 143
IP  - 6
DP  - 2010 Dec
TI  - Effect of pharyngeal packing during nasal surgery on postoperative nausea and
      vomiting.
PG  - 831-6
LID - 10.1016/j.otohns.2010.08.030 [doi]
AB  - OBJECTIVE: The aim of this study was to evaluate the efficacy of pharyngeal
      packing in reducing postoperative nausea and vomiting (PONV) after nasal surgery 
      by taking into consideration the surgery types. STUDY DESIGN: A prospective,
      randomized, controlled trial. SETTING: A tertiary referral center. SUBJECTS AND
      METHODS: After the study was approved by the local ethics committee, this study
      was conducted in the Otorhinolaryngology clinic with the collaboration of the
      Anesthesiology clinic. The development of PONV within 24 hours after surgery was 
      evaluated in patients who were applied a pharyngeal pack (Group 1) or not (Group 
      2) during nasal surgery. RESULTS: There were 104 adult patients for routine nasal
      surgery included in the current study, yielding 100 (group 1, n = 50; group 2, n 
      = 50) evaluable subjects. No significant difference was found in the incidence of
      PONV between the two groups at two (P = 0.41), four (P = 0.54), eight (P = 0.51),
      and 24 hours. According to surgery type, the incidence of PONV after two hours
      was 71 percent in septorhinoplasty, 68 percent in endoscopic sinus surgery, and
      50 percent in septoplasty; after four hours it was 59 percent in
      septorhinoplasty, 53 percent in endoscopic sinus surgery, and 37 percent in
      septoplasty; and after eight hours it was 35 percent in septorhinoplasty, 39
      percent in endoscopic sinus surgery, and 21 percent in septoplasty. PONV was not 
      seen at 24 hours. Compared to the septoplasty group for which pharyngeal packing 
      was used, significantly lower rates of PONV at four and eight hours were found in
      the septoplasty group in which pharyngeal packing was not used (P = 0.02).
      CONCLUSION: Pharyngeal packing in nasal surgery has no impact on PONV.
CI  - Copyright (c) 2010 American Academy of Otolaryngology-Head and Neck Surgery
      Foundation. Published by Mosby, Inc. All rights reserved.
FAU - Korkut, Arzu Yasemin
AU  - Korkut AY
AD  - Department of Otorhinolaryngology, Vakif Gureba Training and Research Hospital,
      Istanbul, Turkey. dryaseminkorkut@yahoo.com
FAU - Erkalp, Kerem
AU  - Erkalp K
FAU - Erden, Veysel
AU  - Erden V
FAU - Teker, Aysenur Meric
AU  - Teker AM
FAU - Demirel, Asiye
AU  - Demirel A
FAU - Gedikli, Orhan
AU  - Gedikli O
FAU - Saidoglu, Leyla
AU  - Saidoglu L
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - Otolaryngol Head Neck Surg
JT  - Otolaryngology--head and neck surgery : official journal of American Academy of
      Otolaryngology-Head and Neck Surgery
JID - 8508176
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Bandages
MH  - Female
MH  - Humans
MH  - Male
MH  - Nose/*surgery
MH  - Pharynx
MH  - Postoperative Nausea and Vomiting/etiology/prevention & control/*therapy
MH  - Prospective Studies
MH  - Rhinoplasty/*adverse effects
MH  - *Tampons, Surgical
MH  - Young Adult
EDAT- 2010/11/27 06:00
MHDA- 2010/12/31 06:00
CRDT- 2010/11/27 06:00
PHST- 2010/06/10 00:00 [received]
PHST- 2010/08/16 00:00 [revised]
PHST- 2010/08/25 00:00 [accepted]
PHST- 2010/11/27 06:00 [entrez]
PHST- 2010/11/27 06:00 [pubmed]
PHST- 2010/12/31 06:00 [medline]
AID - S0194-5998(10)02042-5 [pii]
AID - 10.1016/j.otohns.2010.08.030 [doi]
PST - ppublish
SO  - Otolaryngol Head Neck Surg. 2010 Dec;143(6):831-6. doi:
      10.1016/j.otohns.2010.08.030.


PMID- 21108720
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20101126
IS  - 1445-5994 (Electronic)
IS  - 1444-0903 (Linking)
VI  - 40
IP  - 11
DP  - 2010 Nov
TI  - Questioning the ethics of the ethicists.
PG  - 799; author reply 799-800
LID - 10.1111/j.1445-5994.2010.02310.x [doi]
FAU - Hamor, G P
AU  - Hamor GP
LA  - eng
PT  - Comment
PT  - Letter
PL  - Australia
TA  - Intern Med J
JT  - Internal medicine journal
JID - 101092952
SB  - IM
CON - Intern Med J. 2010 May;40(5):335-41. PMID: 20345507
MH  - Drug Industry/*ethics
MH  - Ethicists/*standards
MH  - Humans
MH  - Physicians/*ethics
EDAT- 2010/11/27 06:00
MHDA- 2011/10/01 06:00
CRDT- 2010/11/27 06:00
PHST- 2010/11/27 06:00 [entrez]
PHST- 2010/11/27 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - 10.1111/j.1445-5994.2010.02310.x [doi]
PST - ppublish
SO  - Intern Med J. 2010 Nov;40(11):799; author reply 799-800. doi:
      10.1111/j.1445-5994.2010.02310.x.


PMID- 21108512
OWN - NLM
STAT- MEDLINE
DCOM- 20110302
LR  - 20191111
IS  - 1873-4332 (Electronic)
IS  - 1083-3188 (Linking)
VI  - 23
IP  - 6 Suppl
DP  - 2010 Dec
TI  - Hemophilia carrier status and counseling the symptomatic and asymptomatic
      adolescent.
PG  - S43-7
AB  - Carriers of hemophilia have a 50% chance of giving birth to a hemophilic son.
      Approximately 35% may have a lower than normal factor VIII or IX and therefore
      can be diagnosed without genetic testing. These individuals may present with
      menorrhagia, menometrorrhagia and dysmenorrhoea. The treatment of menorrhagia is 
      similar to girls without bleeding disorders--tranexamic acid, the oral
      contraceptive pill and, where acceptable, the levonorgestrel-releasing
      intrauterine device. Genetic diagnosis is possible for potential carriers--50%
      families with severe hemophilia carry the intron 22 inversion and databases are
      available which list most of the causative mutations for hemophilia A and B.
      Ideally the mutation in the index in a family is known. The testing of
      adolescents for a recessively inherited condition raises ethical issues and
      guidance may vary within different countries and cultures.
FAU - Winikoff, Rochelle
AU  - Winikoff R
AD  - University of Montreal, Quebec, Canada.
FAU - Lee, Christine
AU  - Lee C
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Pediatr Adolesc Gynecol
JT  - Journal of pediatric and adolescent gynecology
JID - 9610774
SB  - IM
MH  - Adolescent
MH  - Dysmenorrhea/therapy
MH  - Female
MH  - Genetic Carrier Screening
MH  - *Genetic Counseling
MH  - Genetic Testing/*ethics
MH  - Hemophilia A/diagnosis/*genetics
MH  - Hemophilia B/diagnosis/*genetics
MH  - *Heterozygote
MH  - Humans
MH  - Menorrhagia/epidemiology/therapy
MH  - Ovarian Cysts/therapy
EDAT- 2010/11/26 06:00
MHDA- 2011/03/03 06:00
CRDT- 2010/11/26 06:00
PHST- 2010/11/26 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/03/03 06:00 [medline]
AID - S1083-3188(10)00254-8 [pii]
AID - 10.1016/j.jpag.2010.08.010 [doi]
PST - ppublish
SO  - J Pediatr Adolesc Gynecol. 2010 Dec;23(6 Suppl):S43-7. doi:
      10.1016/j.jpag.2010.08.010.


PMID- 21108191
OWN - NLM
STAT- MEDLINE
DCOM- 20110302
LR  - 20101125
IS  - 0040-5930 (Print)
IS  - 0040-5930 (Linking)
VI  - 67
IP  - 12
DP  - 2010 Dec
TI  - [Observations and thoughts while perusing general practice case histories].
PG  - 637-40
LID - 10.1024/0040-5930/a000111 [doi]
AB  - General practitioner's records, growing over years and decades, generally contain
      much more than medical problems. Political, social, psychological, historical,
      statistical, theological, ethical, legal, ecological and economic problems and
      discussions are typical for an intensive contact between a patient and his
      doctor. To fulfill high expectations of patients and their relatives, general
      practitioners must arrange their education and training in an interdisciplinary
      way.
FAU - Horn, Benedikt
AU  - Horn B
AD  - dr.horn@tcnet.ch
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Beobachtungen und Gedanken beim Durchblattern hausarztlicher Krankengeschichten.
PL  - Switzerland
TA  - Ther Umsch
JT  - Therapeutische Umschau. Revue therapeutique
JID - 0407224
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Child
MH  - Chronic Disease/psychology
MH  - Female
MH  - General Practice/*education
MH  - Health Behavior
MH  - Humans
MH  - *Life Change Events
MH  - Male
MH  - *Medical Records
MH  - Middle Aged
MH  - Physician's Role/*psychology
MH  - *Physician-Patient Relations
MH  - Pregnancy
MH  - *Sick Role
MH  - Switzerland
MH  - Young Adult
EDAT- 2010/11/26 06:00
MHDA- 2011/03/03 06:00
CRDT- 2010/11/26 06:00
PHST- 2010/11/26 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/03/03 06:00 [medline]
AID - 10.1024/0040-5930/a000111 [doi]
PST - ppublish
SO  - Ther Umsch. 2010 Dec;67(12):637-40. doi: 10.1024/0040-5930/a000111.


PMID- 21106996
OWN - NLM
STAT- MEDLINE
DCOM- 20110519
LR  - 20110217
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 3
DP  - 2011 Mar
TI  - Transcranial magnetic stimulation: a historical evaluation and future prognosis
      of therapeutically relevant ethical concerns.
PG  - 137-43
LID - 10.1136/jme.2010.039966 [doi]
AB  - Transcranial Magnetic Stimulation (TMS) is a non-invasive neurostimulatory and
      neuromodulatory technique increasingly used in clinical and research practices
      around the world. Historically, the ethical considerations guiding the
      therapeutic practice of TMS were largely concerned with aspects of subject safety
      in clinical trials. While safety remains of paramount importance, the recent US
      Food and Drug Administration approval of the Neuronetics NeuroStar TMS device for
      the treatment of specific medication-resistant depression has raised a number of 
      additional ethical concerns, including marketing, off-label use and technician
      certification. This article provides an overview of the history of TMS and
      highlights the ethical questions that are likely arise as the therapeutic use of 
      TMS continues to expand.
FAU - Horvath, Jared C
AU  - Horvath JC
AD  - Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess
      Medical Center and Harvard Medical School, 330 Brookline Ave KS-158, Boston, MA
      02215, USA. jhorvat2@bidmc.harvard.edu
FAU - Perez, Jennifer M
AU  - Perez JM
FAU - Forrow, Lachlan
AU  - Forrow L
FAU - Fregni, Felipe
AU  - Fregni F
FAU - Pascual-Leone, Alvaro
AU  - Pascual-Leone A
LA  - eng
PT  - Historical Article
PT  - Journal Article
DEP - 20101124
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Bioethical Issues
MH  - Ethics, Medical
MH  - History, 19th Century
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Mental Disorders/*therapy
MH  - Risk Factors
MH  - Transcranial Magnetic Stimulation/*ethics/history/methods
EDAT- 2010/11/26 06:00
MHDA- 2011/05/20 06:00
CRDT- 2010/11/26 06:00
PHST- 2010/11/26 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/05/20 06:00 [medline]
AID - jme.2010.039966 [pii]
AID - 10.1136/jme.2010.039966 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Mar;37(3):137-43. doi: 10.1136/jme.2010.039966. Epub 2010 Nov 
      24.


PMID- 21106779
OWN - NLM
STAT- MEDLINE
DCOM- 20110421
LR  - 20211020
IS  - 1556-679X (Electronic)
IS  - 1556-679X (Linking)
VI  - 18
IP  - 1
DP  - 2011 Jan
TI  - Postexposure prevention of progressive vaccinia in SCID mice treated with
      vaccinia immune globulin.
PG  - 67-74
LID - 10.1128/CVI.00280-10 [doi]
AB  - A recently reported case of progressive vaccinia (PV) in an immunocompromised
      patient has refocused attention on this condition. Uniformly fatal prior to the
      licensure of vaccinia immune globulin (VIG) in 1978, PV was still fatal in about 
      half of VIG-treated patients overall, with a greater mortality rate in infants
      and children. Additional therapies would be needed in the setting of a smallpox
      bioterror event, since mass vaccination following any variola virus release would
      inevitably result in exposure of immunocompromised people through vaccination or 
      contact with vaccinees. Well-characterized animal models of disease can support
      the licensure of new products when human studies are not ethical or feasible, as 
      in the case of PV. We chose vaccinia virus-scarified SCID mice to model PV. As in
      immunocompromised humans, vaccinia virus-scarified SCID animals develop enlarging
      primary lesions with minimal or no inflammation, eventual distal virus spread,
      and lethal outcomes if left untreated. Postexposure treatment with VIG slowed
      disease progression, caused local lesion regression, and resulted in the healthy 
      survival of most of the mice for more than 120 days. Combination treatment with
      VIG and topical cidofovir also resulted in long-term disease-free survival of
      most of the animals, even when initiated 7 days postinfection. These results
      support the possibility that combination treatments may be effective in humans
      and support using this SCID model of PV to test new antibody therapies and
      combination therapies and to provide further insights into the pathogenesis and
      treatment of PV.
FAU - Fisher, R W
AU  - Fisher RW
AD  - Laboratory of Plasma Derivatives, Division of Hematology, Office of Blood
      Research and Review, Center for Biologics Evaluation and Research, Food and Drug 
      Administration, Rockville, Maryland, USA. Robert.Fisher@fda.hhs.gov
FAU - Reed, J L
AU  - Reed JL
FAU - Snoy, P J
AU  - Snoy PJ
FAU - Mikolajczyk, M G
AU  - Mikolajczyk MG
FAU - Bray, M
AU  - Bray M
FAU - Scott, D E
AU  - Scott DE
FAU - Kennedy, M C
AU  - Kennedy MC
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20101124
PL  - United States
TA  - Clin Vaccine Immunol
JT  - Clinical and vaccine immunology : CVI
JID - 101252125
RN  - 0 (Antiviral Agents)
RN  - 0 (Immunoglobulins)
RN  - 0 (Organophosphonates)
RN  - 8J337D1HZY (Cytosine)
RN  - JIL713Q00N (Cidofovir)
SB  - IM
MH  - Animals
MH  - Antiviral Agents/therapeutic use
MH  - Chlorocebus aethiops
MH  - Cidofovir
MH  - Cytosine/analogs & derivatives/therapeutic use
MH  - Drug Therapy, Combination
MH  - HeLa Cells
MH  - Humans
MH  - Immunoglobulins/administration & dosage/*therapeutic use
MH  - Mice
MH  - Mice, SCID
MH  - Organophosphonates/therapeutic use
MH  - Post-Exposure Prophylaxis
MH  - Skin/pathology/virology
MH  - Survival Rate
MH  - Vaccination
MH  - Vaccinia/*drug therapy/mortality/physiopathology/virology
MH  - Vaccinia virus/*immunology/isolation & purification/*pathogenicity
MH  - Vero Cells
PMC - PMC3019770
EDAT- 2010/11/26 06:00
MHDA- 2011/04/22 06:00
CRDT- 2010/11/26 06:00
PHST- 2010/11/26 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/04/22 06:00 [medline]
AID - CVI.00280-10 [pii]
AID - 10.1128/CVI.00280-10 [doi]
PST - ppublish
SO  - Clin Vaccine Immunol. 2011 Jan;18(1):67-74. doi: 10.1128/CVI.00280-10. Epub 2010 
      Nov 24.


PMID- 21106660
OWN - NLM
STAT- MEDLINE
DCOM- 20110421
LR  - 20220408
IS  - 1931-3543 (Electronic)
IS  - 0012-3692 (Linking)
VI  - 139
IP  - 3
DP  - 2011 Mar
TI  - Randomized, controlled trials of interventions to improve communication in
      intensive care: a systematic review.
PG  - 543-554
LID - S0012-3692(11)60121-9 [pii]
LID - 10.1378/chest.10-0595 [doi]
AB  - BACKGROUND: Communication between families and providers in the ICU affects
      patient and family outcomes and use of health-care resources. Recent research
      studies have tested interventions designed to improve communication quality and
      outcomes between providers and families of patients in the ICU. We conducted a
      systematic review of these studies. METHODS: We searched the MEDLINE, PsychInfo, 
      Cochrane, and Cumulative Index to Nursing and Allied Health Literature (CINAHL)
      databases from 1995 to July 2010. We included studies that reported controlled
      clinical interventions designed to improve communication between providers and
      families of patients in the ICU aged 18 years or older. We abstracted all
      selected studies to a standardized data collection instrument and completed a
      quality checklist based on recommendations from the Consolidated Standards for
      Reporting Trials (CONSORT) investigators. RESULTS: In all, 2,841 articles were
      identified. Of those articles, 180 met the criteria for full review, and 21
      articles of 16 distinct interventions met the full inclusion criteria, of which
      five were randomized. Interventions studied included printed information or
      structured family conferences, with or without additional family support.
      Conferences aimed to communicate the diagnosis and prognosis, elicit patient
      values, assess family understanding, and clarify the goals of treatment. Printed 
      information, palliative care or ethics consultation, or regular, structured
      communication by the usual ICU team reduced family distress, improved
      comprehension, and decreased the use of intensive treatments. CONCLUSIONS: The
      evidence supports the use of printed information and structured communication by 
      the usual ICU team, ethics consultation, or palliative care consultation to
      improve family emotional outcomes and to reduce ICU length of stay and treatment 
      intensity. Evidence that these interventions reduce total costs is inconclusive. 
      A comprehensive research agenda should ensure the future study of a full range of
      patient-centered outcomes.
FAU - Scheunemann, Leslie P
AU  - Scheunemann LP
AD  - Division of Geriatric Medicine and Center for Aging and Health, University of
      North Carolina Hospitals, Chapel Hill, NC. Electronic address:
      lscheune@unch.unc.edu.
FAU - McDevitt, Michelle
AU  - McDevitt M
AD  - Medical Intensive Care Unit, University of North Carolina Hospitals, Chapel Hill,
      NC.
FAU - Carson, Shannon S
AU  - Carson SS
AD  - Medical Intensive Care Unit, University of North Carolina Hospitals, Chapel Hill,
      NC; Division of Pulmonary and Critical Care Medicine, University of North
      Carolina Hospitals, Chapel Hill, NC.
FAU - Hanson, Laura C
AU  - Hanson LC
AD  - Division of Geriatric Medicine and Center for Aging and Health, University of
      North Carolina Hospitals, Chapel Hill, NC; Palliative Care Program, University of
      North Carolina, Chapel Hill, NC; Cecil B. Sheps Center for Health Services
      Research, University of North Carolina, Chapel Hill, NC.
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20101124
PL  - United States
TA  - Chest
JT  - Chest
JID - 0231335
SB  - IM
MH  - *Communication
MH  - *Family
MH  - *Health Personnel
MH  - Humans
MH  - *Intensive Care Units
MH  - Length of Stay
MH  - Palliative Care/ethics
MH  - Process Assessment, Health Care
MH  - Randomized Controlled Trials as Topic
MH  - Treatment Outcome
EDAT- 2010/11/26 06:00
MHDA- 2011/04/22 06:00
CRDT- 2010/11/26 06:00
PHST- 2010/11/26 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/04/22 06:00 [medline]
AID - S0012-3692(11)60121-9 [pii]
AID - 10.1378/chest.10-0595 [doi]
PST - ppublish
SO  - Chest. 2011 Mar;139(3):543-554. doi: 10.1378/chest.10-0595. Epub 2010 Nov 24.


PMID- 21106279
OWN - NLM
STAT- MEDLINE
DCOM- 20111102
LR  - 20220331
IS  - 1532-2793 (Electronic)
IS  - 0260-6917 (Linking)
VI  - 31
IP  - 6
DP  - 2011 Aug
TI  - Evaluating a hybrid web-based basic genetics course for health professionals.
PG  - 638-42
LID - 10.1016/j.nedt.2010.11.001 [doi]
AB  - Health professionals, particularly nurses, continue to struggle with the
      expanding role of genetics information in the care of their patients. This paper 
      describes an evaluation study of the effectiveness of a hybrid basic genetics
      course for healthcare professionals combining web-based learning with traditional
      face-to-face instructional techniques. A multidisciplinary group from the
      National Institutes of Health (NIH) created "Basic Genetics Education for
      Healthcare Providers" (BGEHCP). This program combined 7 web-based self-education 
      modules with monthly traditional face-to-face lectures by genetics experts. The
      course was pilot tested by 186 healthcare providers from various disciplines with
      69% (n=129) of the class registrants enrolling in a pre-post evaluation trial.
      Outcome measures included critical thinking knowledge items and a Web-based
      Learning Environment Inventory (WEBLEI). Results indicated a significant
      (p<0.001) change in knowledge scores. WEBLEI scores indicated program
      effectiveness particularly in the area of convenience, access and the course
      structure and design. Although significant increases in overall knowledge scores 
      were achieved, scores in content areas surrounding genetic risk identification
      and ethical issues regarding genetic testing reflected continued gaps in
      knowledge. Web-based genetics education may help overcome genetics knowledge
      deficits by providing access for health professionals with diverse schedules in a
      variety of national and international settings.
CI  - Published by Elsevier Ltd.
FAU - Wallen, Gwenyth R
AU  - Wallen GR
AD  - National Institutes of Health, Clinical Center, Nursing Research and
      Translational Science, 10 Center Drive, Room 2B14, MSC-1151, Bethesda, MD
      20892-1151, USA. GWallen@cc.nih.gov
FAU - Cusack, Georgie
AU  - Cusack G
FAU - Parada, Suzan
AU  - Parada S
FAU - Miller-Davis, Claiborne
AU  - Miller-Davis C
FAU - Cartledge, Tannia
AU  - Cartledge T
FAU - Yates, Jan
AU  - Yates J
LA  - eng
GR  - Z99 CL999999/ImNIH/Intramural NIH HHS/United States
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20101123
PL  - Scotland
TA  - Nurse Educ Today
JT  - Nurse education today
JID - 8511379
MH  - Adult
MH  - Education, Nursing, Continuing/*methods
MH  - Female
MH  - Genetics, Medical/*education
MH  - Health Personnel/*education
MH  - Humans
MH  - *Internet
MH  - Male
MH  - Middle Aged
MH  - Nursing Education Research
MH  - Pilot Projects
MH  - Program Evaluation
MH  - Prospective Studies
MH  - Young Adult
PMC - PMC3049200
MID - NIHMS251861
EDAT- 2010/11/26 06:00
MHDA- 2011/11/04 06:00
CRDT- 2010/11/26 06:00
PHST- 2010/07/29 00:00 [received]
PHST- 2010/10/28 00:00 [revised]
PHST- 2010/11/01 00:00 [accepted]
PHST- 2010/11/26 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
AID - S0260-6917(10)00218-2 [pii]
AID - 10.1016/j.nedt.2010.11.001 [doi]
PST - ppublish
SO  - Nurse Educ Today. 2011 Aug;31(6):638-42. doi: 10.1016/j.nedt.2010.11.001. Epub
      2010 Nov 23.


PMID- 21106197
OWN - NLM
STAT- MEDLINE
DCOM- 20120418
LR  - 20120110
IS  - 1879-0267 (Electronic)
IS  - 0020-1383 (Linking)
VI  - 43
IP  - 1
DP  - 2012 Jan
TI  - Deaths at a Level 1 Trauma Unit: a clinical finding and post-mortem correlation
      study.
PG  - 91-5
LID - 10.1016/j.injury.2010.11.004 [doi]
AB  - BACKGROUND: Missed injuries continue to cause deaths amongst trauma patients.
      Regardless of the definition of missed injuries, it is important to identify all 
      injuries at any stage in the care of trauma patients in order to improve patient 
      outcome. This study was performed to evaluate to what extent missed injuries
      contribute to a fatal outcome at a new Level 1 Trauma Unit. METHODS: The medical 
      records and autopsy reports of all trauma patients who died at the IALCH trauma
      unit from March 2007 through August 2009 were reviewed. The mortality rate and
      incidence of missed injuries were determined. A missed injury was defined as one 
      that was found at autopsy but was not mentioned in the medical records or in any 
      ante mortem radiological report. This excluded minor injuries such as superficial
      contusions and minor lacerations, which are sometimes not included in the case
      notes during resuscitation. Deaths due to trauma are considered unnatural and
      legal provisions require that all unnatural deaths undergo medico-legal
      postmortem examination. The study was approved by the UKZN Biomedical Research
      Ethics Committee. RESULTS: Five hundred and forty-seven patients were admitted to
      the trauma unit of which 135 (24.7%) demised. Three patients were excluded, due
      to inability to retrieve their autopsy reports, leaving a study group of 132
      patients in which there were 100 males and 32 females. The mean age was 33.2
      years, mean ISS was 34.0. A total of 26 missed injuries were found in 14
      patients, giving a total incidence of 10.6%. Three percent had missed injuries
      that were variously deemed to be possibly related, probably related, or related
      to the fatal outcome, whether the deaths were deemed preventable or not. Severe
      physiological derangement which precluded any imaging before death may have
      caused the injury to be overlooked. The thorax was the anatomical region where
      most injuries were missed. CONCLUSIONS: A number of injuries remain undetected in
      trauma care and are found only at autopsy, emphasizing that the autopsy remains
      an important tool in evaluating trauma care. However, in only a few patients did 
      the missed injuries have a detrimental effect on outcome.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Steinwall, David
AU  - Steinwall D
AD  - Section of Forensic Medicine, Dept of Community Health and Rehabilitation, Umea
      University, PO Box 7616, SE-907 12 Umea, Sweden.
FAU - Befrits, Fabian
AU  - Befrits F
FAU - Naidoo, Steve R
AU  - Naidoo SR
FAU - Hardcastle, Timothy
AU  - Hardcastle T
FAU - Eriksson, Anders
AU  - Eriksson A
FAU - Muckart, David J J
AU  - Muckart DJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101123
PL  - Netherlands
TA  - Injury
JT  - Injury
JID - 0226040
SB  - IM
MH  - Accidents, Traffic/*mortality/*statistics & numerical data
MH  - Autopsy
MH  - *Cause of Death
MH  - Diagnostic Errors/*statistics & numerical data
MH  - Female
MH  - Hospitalization/statistics & numerical data
MH  - Humans
MH  - Incidence
MH  - Injury Severity Score
MH  - Male
MH  - Medical Records
MH  - Retrospective Studies
MH  - Trauma Centers
MH  - Wounds and Injuries/*mortality/*pathology
EDAT- 2010/11/26 06:00
MHDA- 2012/04/19 06:00
CRDT- 2010/11/26 06:00
PHST- 2010/09/30 00:00 [received]
PHST- 2010/11/01 00:00 [accepted]
PHST- 2010/11/26 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2012/04/19 06:00 [medline]
AID - S0020-1383(10)00743-6 [pii]
AID - 10.1016/j.injury.2010.11.004 [doi]
PST - ppublish
SO  - Injury. 2012 Jan;43(1):91-5. doi: 10.1016/j.injury.2010.11.004. Epub 2010 Nov 23.


PMID- 21106182
OWN - NLM
STAT- MEDLINE
DCOM- 20110301
LR  - 20121115
IS  - 0767-0974 (Print)
IS  - 0767-0974 (Linking)
VI  - 26
IP  - 11
DP  - 2010 Nov
TI  - [IGEM 2009: synthetic biology and ethics].
PG  - 986-92
LID - 10.1051/medsci/20102611986 [doi]
FAU - Hafner, Sophia
AU  - Hafner S
AD  - Ecole normale superieure et Medecine/Sciences, 45 rue d'Ulm, Paris, France.
      sophia.hafner@ens.fr
LA  - fre
PT  - Journal Article
TT  - Les iGEM 2009: la biologie synth-ethique.
PL  - France
TA  - Med Sci (Paris)
JT  - Medecine sciences : M/S
JID - 8710980
SB  - IM
MH  - Bacterial Physiological Phenomena
MH  - Biotechnology/*standards
MH  - *Ethics Committees
MH  - *Ethics, Institutional
MH  - Female
MH  - Genetic Therapy/standards
MH  - Genetic Vectors
MH  - Humans
MH  - Male
MH  - Neoplasms/therapy
MH  - Plasmids/therapeutic use
MH  - Synthetic Biology/*standards
EDAT- 2010/11/26 06:00
MHDA- 2011/03/02 06:00
CRDT- 2010/11/26 06:00
PHST- 2010/11/26 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/03/02 06:00 [medline]
AID - 00/00/0F/FF/ [pii]
AID - 10.1051/medsci/20102611986 [doi]
PST - ppublish
SO  - Med Sci (Paris). 2010 Nov;26(11):986-92. doi: 10.1051/medsci/20102611986.


PMID- 21105948
OWN - NLM
STAT- MEDLINE
DCOM- 20110401
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 38
IP  - 4
DP  - 2010 Winter
TI  - How bioethics can enrich medical-legal collaborations.
PG  - 847-62
LID - 10.1111/j.1748-720X.2010.00538.x [doi]
AB  - Medical-legal partnerships (MLPs) - collaborative endeavors between health care
      clinicians and lawyers to more effectively address issues impacting health care -
      have proliferated over the past decade. The goal of this interdisciplinary
      approach is to improve the health outcomes and quality of life of patients and
      families, recognizing the many non-medical influences on health care and thus the
      value of an interdisciplinary team to enhance health. This article examines the
      unique, interrelated ethical issues that confront the clinical and legal partners
      involved in MLPs. We contend that the ethical precepts of the clinical and legal 
      professions should be seen as opportunities, not barriers, to further the
      interdisciplinary nature of MLPs. The commonalities in ethical approaches
      represent a potential bridge between legal and health care advocacy for
      patient/client well-being. Bioethics has a role to play in building and analyzing
      this bridge: bioethics may serve as a discourse and method to enhance
      collaboration by highlighting common ethical foundations and refocusing legal and
      clinical partners on their similar goals of service for patients/clients. This
      article explores this bridging role of bioethics, through a series of case
      studies. It concludes with recommendations to strengthen the collaborations.
CI  - (c) 2010 American Society of Law, Medicine & Ethics, Inc.
FAU - Campbell, Amy T
AU  - Campbell AT
AD  - Center of Bioethics and Humanities, Upstate Medical University, USA.
FAU - Sicklick, Jay
AU  - Sicklick J
FAU - Galowitz, Paula
AU  - Galowitz P
FAU - Retkin, Randye
AU  - Retkin R
FAU - Fleishman, Stewart B
AU  - Fleishman SB
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Adolescent
MH  - Aged
MH  - Delivery of Health Care/*ethics/*legislation & jurisprudence
MH  - Ethicists/*legislation & jurisprudence
MH  - Female
MH  - Humans
MH  - *Interprofessional Relations
MH  - *Lawyers
MH  - Male
MH  - Middle Aged
MH  - *Physicians
MH  - Professional Role
MH  - United States
EDAT- 2010/11/26 06:00
MHDA- 2011/04/02 06:00
CRDT- 2010/11/26 06:00
PHST- 2010/11/26 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/04/02 06:00 [medline]
AID - 10.1111/j.1748-720X.2010.00538.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2010 Winter;38(4):847-62. doi:
      10.1111/j.1748-720X.2010.00538.x.


PMID- 21105947
OWN - NLM
STAT- MEDLINE
DCOM- 20110401
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 38
IP  - 4
DP  - 2010 Winter
TI  - The inalienable right to withdraw from research.
PG  - 840-6
LID - 10.1111/j.1748-720X.2010.00537.x [doi]
AB  - Most codes of research ethics and the practice of Institutional Review Boards
      (IRBs) allow human subjects to withdraw from research at any time. Consent forms 
      invariably make a statement to this effect. So understood, a subject's right to
      withdraw from research is inalienable; she cannot, through her consent, surrender
      this right. Recently critics have argued that in selected circumstances the right
      to withdraw from research is alienable; subjects have the moral authority,
      through their consent, to obligate themselves not to withdraw. Two kinds of cases
      have been cited to support this. In one case, there will be great benefits lost
      if subjects are permitted to withdraw before the completion of the protocol. In
      the other case, there will be harm to third parties if subjects withdraw from the
      experiment. In this paper, I defend the inalienability of the right to withdraw
      from research. I argue, first, that securing the desired benefits and avoiding
      the feared harms can be achieved without allowing waiver. Second, I show that
      permitting waiver in these cases does not guarantee that the ends sought will be 
      achieved. And third, I articulate positive reasons for conceiving subjects' right
      to withdraw from research as inalienable.
CI  - (c) 2010 American Society of Law, Medicine & Ethics, Inc.
FAU - McConnell, Terrance
AU  - McConnell T
AD  - University of North Carolina, Greensboro, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Codes of Ethics
MH  - Human Experimentation/*ethics/legislation & jurisprudence
MH  - *Human Rights
MH  - Humans
MH  - Informed Consent/*ethics/legislation & jurisprudence
MH  - Moral Obligations
MH  - Patient Dropouts/legislation & jurisprudence
MH  - *Research Subjects
MH  - Transplantation, Heterologous
MH  - United States
EDAT- 2010/11/26 06:00
MHDA- 2011/04/02 06:00
CRDT- 2010/11/26 06:00
PHST- 2010/11/26 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/04/02 06:00 [medline]
AID - 10.1111/j.1748-720X.2010.00537.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2010 Winter;38(4):840-6. doi: 10.1111/j.1748-720X.2010.00537.x.


PMID- 21105941
OWN - NLM
STAT- MEDLINE
DCOM- 20110401
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 38
IP  - 4
DP  - 2010 Winter
TI  - Physicians should treat mentally ill death row inmates, even if treatment is
      refused.
PG  - 774-88
LID - 10.1111/j.1748-720X.2010.00531.x [doi]
AB  - Competency to be executed evaluations are conducted with a clear understanding
      that no physician-patient relationship exists. Treatment however, is not so
      neatly re-categorized in large measure because it involves the physician's active
      provision of the healing arts. A natural tension exists between what practices
      may be legally permissible and what are ethically acceptable. We present an
      overview of the existing positions on this matter in the process of framing our
      argument.
CI  - (c) 2010 American Society of Law, Medicine & Ethics, Inc.
FAU - McDonnell, Melissa
AU  - McDonnell M
AD  - Court of Appeals of Maryland, USA.
FAU - Phillips, Robert T M
AU  - Phillips RT
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - *Capital Punishment
MH  - Coercion
MH  - *Ethics, Medical
MH  - Forensic Psychiatry/ethics/legislation & jurisprudence
MH  - Humans
MH  - Male
MH  - Mental Competency/*legislation & jurisprudence
MH  - Middle Aged
MH  - Patient Rights/legislation & jurisprudence
MH  - Physician-Patient Relations/ethics
MH  - Practice Guidelines as Topic
MH  - Prisoners/legislation & jurisprudence/*psychology
MH  - Treatment Refusal/*legislation & jurisprudence
MH  - United States
EDAT- 2010/11/26 06:00
MHDA- 2011/04/02 06:00
CRDT- 2010/11/26 06:00
PHST- 2010/11/26 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/04/02 06:00 [medline]
AID - 10.1111/j.1748-720X.2010.00531.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2010 Winter;38(4):774-88. doi:
      10.1111/j.1748-720X.2010.00531.x.


PMID- 21105940
OWN - NLM
STAT- MEDLINE
DCOM- 20110401
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 38
IP  - 4
DP  - 2010 Winter
TI  - Physicians must honor refusal of treatment to restore competency by non-dangerous
      inmates on death row.
PG  - 764-73
LID - 10.1111/j.1748-720X.2010.00530.x [doi]
AB  - The role of physicians in death penalty cases has provoked discussion in both the
      legal system as well as in professional organizations. Professional groups have
      responded by developing ethical guidelines advising physicians as to current
      ethical standards. Psychiatric dilemmas as a subspecialty with unique roles have 
      required more specific guidelines. A clinical vignette provides a focus to
      explicate the conflicts.
CI  - (c) 2010 American Society of Law, Medicine & Ethics, Inc.
FAU - Zonana, Howard
AU  - Zonana H
AD  - American Academy of Psychiatry and the Law, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
RN  - 0 (Antipsychotic Agents)
MH  - Antipsychotic Agents/therapeutic use
MH  - *Capital Punishment
MH  - Ethics, Medical
MH  - Forensic Psychiatry/ethics/legislation & jurisprudence
MH  - Humans
MH  - Male
MH  - Mental Competency/*legislation & jurisprudence
MH  - Middle Aged
MH  - Patient Rights/legislation & jurisprudence
MH  - Physician-Patient Relations/*ethics
MH  - Practice Guidelines as Topic
MH  - Prisoners/legislation & jurisprudence/*psychology
MH  - Schizophrenia/drug therapy
MH  - Treatment Refusal/*legislation & jurisprudence
MH  - United States
EDAT- 2010/11/26 06:00
MHDA- 2011/04/02 06:00
CRDT- 2010/11/26 06:00
PHST- 2010/11/26 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/04/02 06:00 [medline]
AID - 10.1111/j.1748-720X.2010.00530.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2010 Winter;38(4):764-73. doi:
      10.1111/j.1748-720X.2010.00530.x.


PMID- 21105881
OWN - NLM
STAT- MEDLINE
DCOM- 20110616
LR  - 20110309
IS  - 1539-6924 (Electronic)
IS  - 0272-4332 (Linking)
VI  - 31
IP  - 3
DP  - 2011 Mar
TI  - The role of emotions in risk communication.
PG  - 450-65
LID - 10.1111/j.1539-6924.2010.01530.x [doi]
AB  - We present two experiments investigating the role of emotions concerning
      technological and natural hazards. In the first experiment, technological hazards
      aroused stronger emotions, and were considered to be riskier than natural
      hazards. No differences were found between the texts versus audio presentations. 
      However, the presence of pictures aroused stronger emotions and increased the
      perceived risk. Emotions play a mediating role between hazard types and perceived
      risk, as well as between pictures and perceived risk. The second experiment
      adopted real-world materials from webpages and TV. Emotions again play a
      mediating role between pictorial information and risk perception. Moreover,
      specific emotions were found to be associated with different types of action
      tendencies. For example, loss-based emotions (e.g., fear, regret) tend to lead to
      prevention strategies, whereas ethical emotions (e.g., anger) lead to aggressive 
      behavior. We also find that loss-based emotions in the technical hazard scenario 
      trigger more coping strategies (from prevention to retaliation) than in the
      natural hazard scenario.
CI  - (c) 2010 Society for Risk Analysis.
FAU - Xie, Xiao-Fei
AU  - Xie XF
AD  - Department of Psychology, Peking University, Beijing 100871, China.
FAU - Wang, Mei
AU  - Wang M
FAU - Zhang, Ruo-Gu
AU  - Zhang RG
FAU - Li, Jie
AU  - Li J
FAU - Yu, Qing-Yuan
AU  - Yu QY
LA  - eng
PT  - Journal Article
DEP - 20101124
PL  - United States
TA  - Risk Anal
JT  - Risk analysis : an official publication of the Society for Risk Analysis
JID - 8109978
SB  - IM
MH  - Cognition
MH  - *Communication
MH  - *Emotions
MH  - Humans
MH  - *Risk Assessment
EDAT- 2010/11/26 06:00
MHDA- 2011/06/17 06:00
CRDT- 2010/11/26 06:00
PHST- 2010/11/26 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/06/17 06:00 [medline]
AID - 10.1111/j.1539-6924.2010.01530.x [doi]
PST - ppublish
SO  - Risk Anal. 2011 Mar;31(3):450-65. doi: 10.1111/j.1539-6924.2010.01530.x. Epub
      2010 Nov 24.


PMID- 21105763
OWN - NLM
STAT- MEDLINE
DCOM- 20110422
LR  - 20211020
IS  - 1557-7740 (Electronic)
IS  - 1557-7740 (Linking)
VI  - 13
IP  - 12
DP  - 2010 Dec
TI  - A strategy to advance the evidence base in palliative medicine: formation of a
      palliative care research cooperative group.
PG  - 1407-13
LID - 10.1089/jpm.2010.0261 [doi]
AB  - BACKGROUND: Palliative medicine has made rapid progress in establishing its
      scientific and clinical legitimacy, yet the evidence base to support clinical
      practice remains deficient in both the quantity and quality of published studies.
      Historically, the conduct of research in palliative care populations has been
      impeded by multiple barriers including health care system fragmentation, small
      number and size of potential sites for recruitment, vulnerability of the
      population, perceptions of inappropriateness, ethical concerns, and gate-keeping.
      METHODS: A group of experienced investigators with backgrounds in palliative care
      research convened to consider developing a research cooperative group as a
      mechanism for generating high-quality evidence on prioritized, clinically
      relevant topics in palliative care. RESULTS: The resulting Palliative Care
      Research Cooperative (PCRC) agreed on a set of core principles: active,
      interdisciplinary membership; commitment to shared research purposes;
      heterogeneity of participating sites; development of research capacity in
      participating sites; standardization of methodologies, such as consenting and
      data collection/management; agile response to research requests from government, 
      industry, and investigators; focus on translation; education and training of
      future palliative care researchers; actionable results that can inform clinical
      practice and policy. Consensus was achieved on a first collaborative study, a
      randomized clinical trial of statin discontinuation versus continuation in
      patients with a prognosis of less than 6 months who are taking statins for
      primary or secondary prevention. This article describes the formation of the
      PCRC, highlighting processes and decisions taken to optimize the cooperative
      group's success.
FAU - Abernethy, Amy P
AU  - Abernethy AP
AD  - Division of Medical Oncology, Department of Medicine, Duke University Medical
      Center, Durham, North Carolina 27710, USA. amy.abernethy@duke.edu
FAU - Aziz, Noreen M
AU  - Aziz NM
FAU - Basch, Ethan
AU  - Basch E
FAU - Bull, Janet
AU  - Bull J
FAU - Cleeland, Charles S
AU  - Cleeland CS
FAU - Currow, David C
AU  - Currow DC
FAU - Fairclough, Diane
AU  - Fairclough D
FAU - Hanson, Laura
AU  - Hanson L
FAU - Hauser, Joshua
AU  - Hauser J
FAU - Ko, Danielle
AU  - Ko D
FAU - Lloyd, Linda
AU  - Lloyd L
FAU - Morrison, R Sean
AU  - Morrison RS
FAU - Otis-Green, Shirley
AU  - Otis-Green S
FAU - Pantilat, Steve
AU  - Pantilat S
FAU - Portenoy, Russell K
AU  - Portenoy RK
FAU - Ritchie, Christine
AU  - Ritchie C
FAU - Rocker, Graeme
AU  - Rocker G
FAU - Wheeler, Jane L
AU  - Wheeler JL
FAU - Zafar, S Yousuf
AU  - Zafar SY
FAU - Kutner, Jean S
AU  - Kutner JS
LA  - eng
GR  - U24 NR014637/NR/NINR NIH HHS/United States
GR  - U2C NR014637/NR/NINR NIH HHS/United States
GR  - UC4 NR012584/NR/NINR NIH HHS/United States
PT  - Journal Article
DEP - 20101124
PL  - United States
TA  - J Palliat Med
JT  - Journal of palliative medicine
JID - 9808462
SB  - IM
CIN - J Palliat Med. 2010 Nov;13(11):1304. PMID: 21091020
MH  - *Cooperative Behavior
MH  - *Evidence-Based Medicine
MH  - *Health Services Research
MH  - Humans
MH  - *Palliative Care
PMC - PMC3876423
EDAT- 2010/11/26 06:00
MHDA- 2011/04/26 06:00
CRDT- 2010/11/26 06:00
PHST- 2010/11/26 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/04/26 06:00 [medline]
AID - 10.1089/jpm.2010.0261 [doi]
PST - ppublish
SO  - J Palliat Med. 2010 Dec;13(12):1407-13. doi: 10.1089/jpm.2010.0261. Epub 2010 Nov
      24.


PMID- 21105756
OWN - NLM
STAT- MEDLINE
DCOM- 20110103
LR  - 20190518
IS  - 0261-1929 (Print)
IS  - 0261-1929 (Linking)
VI  - 38
IP  - 5
DP  - 2010 Oct
TI  - An assessment of the use of chimpanzees in hepatitis C research past, present and
      future: 1. Validity of the chimpanzee model.
PG  - 387-418
AB  - The USA is the only significant user of chimpanzees in biomedical research in the
      world, since many countries have banned or limited the practice due to
      substantial ethical, economic and scientific concerns. Advocates of chimpanzee
      use cite hepatitis C research as a major reason for its necessity and
      continuation, in spite of supporting evidence that is scant and often anecdotal. 
      This paper examines the scientific and ethical issues surrounding chimpanzee
      hepatitis C research, and concludes that claims of the necessity of chimpanzees
      in historical and future hepatitis C research are exaggerated and unjustifiable, 
      respectively. The chimpanzee model has several major scientific, ethical,
      economic and practical caveats. It has made a relatively negligible contribution 
      to knowledge of, and tangible progress against, the hepatitis C virus compared to
      non-chimpanzee research, and must be considered scientifically redundant, given
      the array of alternative methods of inquiry now available. The continuation of
      chimpanzee use in hepatitis C research adversely affects scientific progress, as 
      well as chimpanzees and humans in need of treatment. Unfounded claims of its
      necessity should not discourage changes in public policy regarding the use of
      chimpanzees in US laboratories.
CI  - (c) 2010 FRAME.
FAU - Bailey, Jarrod
AU  - Bailey J
AD  - New England Anti-Vivisection Society, Boston, MA 02108-5100, USA.
      jarrod.bailey@mac.com
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Altern Lab Anim
JT  - Alternatives to laboratory animals : ATLA
JID - 8110074
RN  - 0 (Antiviral Agents)
RN  - 0 (Viral Hepatitis Vaccines)
SB  - IM
MH  - Animals
MH  - Antiviral Agents/therapeutic use
MH  - Disease Models, Animal
MH  - *Hepacivirus/immunology
MH  - Hepatitis C/drug therapy/virology
MH  - Pan troglodytes/*virology
MH  - Viral Hepatitis Vaccines/immunology
EDAT- 2010/11/26 06:00
MHDA- 2011/01/05 06:00
CRDT- 2010/11/26 06:00
PHST- 2010/11/26 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/01/05 06:00 [medline]
AID - 10.1177/026119291003800501 [doi]
PST - ppublish
SO  - Altern Lab Anim. 2010 Oct;38(5):387-418. doi: 10.1177/026119291003800501.


PMID- 21104946
OWN - NLM
STAT- MEDLINE
DCOM- 20110307
LR  - 20101124
IS  - 1471-2857 (Electronic)
IS  - 0957-9664 (Linking)
VI  - 20
IP  - 5
DP  - 2010 Dec
TI  - Contemplating common ground in the professional ethics of forensic psychiatry.
PG  - 307-22
LID - 10.1002/cbm.789 [doi]
FAU - Grounds, Adrian
AU  - Grounds A
FAU - Gunn, John
AU  - Gunn J
FAU - Myers, Wade C
AU  - Myers WC
FAU - Rosner, Richard
AU  - Rosner R
FAU - Busch, Kenneth G
AU  - Busch KG
LA  - eng
PT  - Editorial
PL  - England
TA  - Crim Behav Ment Health
JT  - Criminal behaviour and mental health : CBMH
JID - 9309668
SB  - IM
MH  - *Ethics, Professional
MH  - Forensic Psychiatry/*ethics
EDAT- 2010/11/26 06:00
MHDA- 2011/03/08 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/03/08 06:00 [medline]
AID - 10.1002/cbm.789 [doi]
PST - ppublish
SO  - Crim Behav Ment Health. 2010 Dec;20(5):307-22. doi: 10.1002/cbm.789.


PMID- 21104653
OWN - NLM
STAT- MEDLINE
DCOM- 20150112
LR  - 20171213
IS  - 1724-6075 (Electronic)
IS  - 0391-5603 (Linking)
VI  - 77 Suppl 16
DP  - 2010 Jan-Mar
TI  - [Informed consent and risk management: medico-legal aspects].
PG  - 5-10
AB  - In every relief run, both to the goals of medical performance quality and in the 
      optics of a therapeutic alliance, it is fundamental to create a relationship of
      trust among the physician and the patient, in which communication assumes a
      fundamental role. The informed consent is set as an integral part of the sanitary
      action as conclusive moment of that "therapeutic alliance" fundamental to face in
      a correct way every illness, and it legitimates the same sanitary action, as it
      is the demonstration of the constitutionally guaranteed right of patient's
      autodetermination. The A.O.U.D. of Udine has undertaken a run of accreditation to
      the Joint Commission International that it foresees a revision of the informative
      runs and an updating of the forms of informed consent, with the purpose to
      overcome the traditional physician-patient relationship, recognizing to all the
      patients an active role in the exercise of the medical action and in the care
      process. In fact the information must be lived as integral part of the sanitary
      action, with the awareness that this, private of such a part, would result
      incomplete and inaccurate, independently from the result. In such optics, the
      consent form, created absorbing legislative, ethical and deontological principles
      and jurisprudential orientations, will be illustrated and particular
      considerations about the type of information that must be given to the patient
      for treatments effected in day-surgery, will be formulated.
FAU - Moreschi, C
AU  - Moreschi C
FAU - Leone, E
AU  - Leone E
FAU - Sabot, A
AU  - Sabot A
LA  - ita
PT  - English Abstract
PT  - Journal Article
TT  - Il consenso informato e la gestione del rischio: aspetti medico legali.
PL  - United States
TA  - Urologia
JT  - Urologia
JID - 0417372
SB  - IM
MH  - Communication Barriers
MH  - Hospitals, University
MH  - Humans
MH  - Informed Consent/*legislation & jurisprudence
MH  - Italy
MH  - Patient Education as Topic
MH  - *Physician-Patient Relations
MH  - Risk Management/*legislation & jurisprudence
MH  - Truth Disclosure
EDAT- 2010/11/26 06:00
MHDA- 2015/01/13 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2015/01/13 06:00 [medline]
AID - 0E723649-6DF1-4144-B03B-42E97CECD881 [pii]
PST - ppublish
SO  - Urologia. 2010 Jan-Mar;77 Suppl 16:5-10.


PMID- 21104509
OWN - NLM
STAT- MEDLINE
DCOM- 20110307
LR  - 20101124
IS  - 1540-8566 (Electronic)
IS  - 0163-9366 (Linking)
VI  - 29
IP  - 4
DP  - 2010 Oct
TI  - Artificial nutrition and hydration at the end of life.
PG  - 347-85
LID - 10.1080/01639366.2010.521020 [doi]
AB  - Considerable controversy surrounds the issue of care at the end of life (EOL) for
      older adults. Technological advances and the legal, ethical, clinical, religious,
      cultural, personal, and fiscal considerations in the provision of artificial
      hydration and nutrition support to older adults near death are presented in this 
      comprehensive review.
FAU - Heuberger, Roschelle A
AU  - Heuberger RA
AD  - Department of Human Environmental Studies, Central Michigan University, Mt.
      Pleasant, Michigan 48859, USA. heube1ra@cmich.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Nutr Elder
JT  - Journal of nutrition for the elderly
JID - 8208739
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Ethics, Medical
MH  - Euthanasia, Passive/*ethics/legislation & jurisprudence
MH  - Humans
MH  - Nutritional Sciences/ethics
MH  - Nutritional Support/*ethics
MH  - Palliative Care/*ethics
MH  - Patient Advocacy/*ethics
EDAT- 2010/11/26 06:00
MHDA- 2011/03/08 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/03/08 06:00 [medline]
AID - 929883689 [pii]
AID - 10.1080/01639366.2010.521020 [doi]
PST - ppublish
SO  - J Nutr Elder. 2010 Oct;29(4):347-85. doi: 10.1080/01639366.2010.521020.


PMID- 21104334
OWN - NLM
STAT- MEDLINE
DCOM- 20120919
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 18
IP  - 2
DP  - 2012 Jun
TI  - A systematic approach to engineering ethics education.
PG  - 339-49
LID - 10.1007/s11948-010-9249-8 [doi]
AB  - Engineering ethics education is a complex field characterized by dynamic topics
      and diverse students, which results in significant challenges for engineering
      ethics educators. The purpose of this paper is to introduce a systematic approach
      to determine what to teach and how to teach in an ethics curriculum. This is a
      topic that has not been adequately addressed in the engineering ethics
      literature. This systematic approach provides a method to: (1) develop a
      context-specific engineering ethics curriculum using the Delphi technique, a
      process-driven research method; and (2) identify appropriate delivery strategies 
      and instructional strategies using an instructional design model. This approach
      considers the context-specific needs of different engineering disciplines in
      ethics education and leverages the collaboration of engineering professors,
      practicing engineers, engineering graduate students, ethics scholars, and
      instructional design experts. The proposed approach is most suitable for a
      department, a discipline/field or a professional society. The approach helps to
      enhance learning outcomes and to facilitate ethics education curriculum
      development as part of the regular engineering curriculum.
FAU - Li, Jessica
AU  - Li J
AD  - Department of Learning Technologies, University of North Texas, UNT Discovery
      Park, 3940 North Elm Street, G150, Denton, TX 76207, USA. Jessica.Li@unt.edu
FAU - Fu, Shengli
AU  - Fu S
LA  - eng
PT  - Journal Article
DEP - 20101123
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Curriculum
MH  - Delphi Technique
MH  - Engineering/*education/ethics
MH  - Ethics, Professional/*education
MH  - Humans
MH  - Models, Educational
MH  - *Teaching
EDAT- 2010/11/26 06:00
MHDA- 2012/09/20 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/05/02 00:00 [received]
PHST- 2010/11/08 00:00 [accepted]
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2012/09/20 06:00 [medline]
AID - 10.1007/s11948-010-9249-8 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2012 Jun;18(2):339-49. doi: 10.1007/s11948-010-9249-8. Epub 2010 
      Nov 23.


PMID- 21104155
OWN - NLM
STAT- MEDLINE
DCOM- 20120919
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 18
IP  - 2
DP  - 2012 Jun
TI  - Assessing graduate student progress in engineering ethics.
PG  - 351-67
LID - 10.1007/s11948-010-9250-2 [doi]
AB  - Under a grant from the National Science Foundation, the authors (and others)
      undertook to integrate ethics into graduate engineering classes at three
      universities-and to assess success in a way allowing comparison across classes
      (and institutions). This paper describes the attempt to carry out that
      assessment. Standard methods of assessment turned out to demand too much class
      time. Under pressure from instructors, the authors developed an alternative
      method that is both specific in content to individual classes and allows
      comparison across classes. Results are statistically significant for ethical
      sensitivity and knowledge. They show measurable improvement in a single semester.
FAU - Davis, Michael
AU  - Davis M
AD  - Humanities Department, Illinois Institute of Technology, 5300 S. Shore Drive #57,
      Chicago, IL, 60615, USA. davism@iit.edu
FAU - Feinerman, Alan
AU  - Feinerman A
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20101121
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Achievement
MH  - Educational Measurement/*standards
MH  - Engineering/*education/ethics
MH  - Ethics, Professional/*education
MH  - Humans
MH  - Professional Competence/*standards
MH  - *Universities
EDAT- 2010/11/26 06:00
MHDA- 2012/09/20 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/07/19 00:00 [received]
PHST- 2010/11/08 00:00 [accepted]
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2012/09/20 06:00 [medline]
AID - 10.1007/s11948-010-9250-2 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2012 Jun;18(2):351-67. doi: 10.1007/s11948-010-9250-2. Epub 2010 
      Nov 21.


PMID- 21103986
OWN - NLM
STAT- MEDLINE
DCOM- 20110727
LR  - 20211020
IS  - 1432-1041 (Electronic)
IS  - 0031-6970 (Linking)
VI  - 67 Suppl 1
DP  - 2011 May
TI  - Ethical key issues and fundamental rights in paediatric research.
PG  - 117-23
LID - 10.1007/s00228-010-0929-8 [doi]
AB  - PURPOSE: This article is aimed at describing the methodology of "ethical
      reasoning" that finally led TEDDYNoE (Task-force in Europe for Drug Development
      for the Young) to propose the integration of international human rights law to
      develop coherent and exhaustive ethical recommendations on paediatric research at
      a European level. METHODS: A large number of ethical guidelines and texts of
      varying legal force existing in the field of clinical research and in particular 
      related to paediatrics are analysed. Differences and non-coordinated
      implementation are pointed out. RESULTS: Differences, tensions or outright
      contradictions among the provisions of these texts can generate confusion leading
      to the adoption of different ethical standards across Europe. In this context,
      the real challenge is to ensure that each child involved in a clinical trial in
      the EU territory may rely directly on the same principles and rights. Taking
      international human rights law as the main starting point to develop a coherent
      framework for paediatric research that incorporates all the relevant ethical
      considerations and existing guidelines is a way of achieving this objective.
      CONCLUSIONS: The implementation, at national and local level, of the "European
      Ethical Recommendations" (Eudralex 2008 vol. 10), based on international human
      rights law, seems to be the next step in facilitating a coordinated approach to
      the application of the Directive 2001/20/EC, as well as developing quality and
      ethically sound paediatric research.
FAU - Altavilla, Annagrazia
AU  - Altavilla A
AD  - Universite de la Mediterranee, Marseille, France. annagrazia.altavilla@univmed.fr
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101120
PL  - Germany
TA  - Eur J Clin Pharmacol
JT  - European journal of clinical pharmacology
JID - 1256165
SB  - IM
MH  - Biomedical Research/*ethics/*legislation & jurisprudence
MH  - Child
MH  - European Union
MH  - Guidelines as Topic
MH  - Human Rights/*legislation & jurisprudence
MH  - Humans
MH  - Pediatrics/*ethics/*legislation & jurisprudence
EDAT- 2010/11/26 06:00
MHDA- 2011/07/28 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/10/12 00:00 [received]
PHST- 2010/10/16 00:00 [accepted]
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/07/28 06:00 [medline]
AID - 10.1007/s00228-010-0929-8 [doi]
PST - ppublish
SO  - Eur J Clin Pharmacol. 2011 May;67 Suppl 1:117-23. doi: 10.1007/s00228-010-0929-8.
      Epub 2010 Nov 20.


PMID- 21103950
OWN - NLM
STAT- MEDLINE
DCOM- 20110701
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 16
IP  - 4
DP  - 2010 Dec
TI  - Responsible research: what is expected? Commentary on: "Statistical power, the
      Belmont Report, and the ethics of clinical trials".
PG  - 693-6
LID - 10.1007/s11948-010-9248-9 [doi]
AB  - "Responsible research" and "good science" are concepts with various meanings
      depending on one's perspective and assumptions. Fellow researchers, research
      participants, policy makers and the general public also have differing
      expectations of the benefits of research ranging from accurate and reliable data 
      that extend the body of knowledge, to solutions to societal concerns. Unless
      these differing constituencies articulate their differing views they may fail to 
      communicate and undermine the value of research to society.
FAU - Bird, Stephanie J
AU  - Bird SJ
AD  - sjbird@mit.edu
LA  - eng
PT  - Comment
PT  - Journal Article
DEP - 20101120
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
CON - Sci Eng Ethics. 2010 Dec;16(4):675-91. PMID: 21063801
MH  - Clinical Trials as Topic/*ethics/standards
MH  - Conflict of Interest
MH  - *Ethics, Research
MH  - Humans
MH  - Information Management/ethics
MH  - Public Policy
MH  - Research Design/*standards
MH  - *Research Personnel
EDAT- 2010/11/26 06:00
MHDA- 2011/07/02 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/10/29 00:00 [received]
PHST- 2010/11/01 00:00 [accepted]
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/07/02 06:00 [medline]
AID - 10.1007/s11948-010-9248-9 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2010 Dec;16(4):693-6. doi: 10.1007/s11948-010-9248-9. Epub 2010
      Nov 20.


PMID- 21103734
OWN - NLM
STAT- MEDLINE
DCOM- 20110406
LR  - 20190608
VI  - 25
IP  - 3
DP  - 2010 Jul-Sep
TI  - Research Ethics Committee: mandatory necessity. Requirement needed.
PG  - III-IV
LID - S0102-76382010000300002 [pii]
FAU - Sa, Michel Pompeu Barros de Oliveira
AU  - Sa MP
FAU - Lima, Ricardo de Carvalho
AU  - Lima Rde C
LA  - eng
LA  - por
PT  - Editorial
PL  - Brazil
TA  - Rev Bras Cir Cardiovasc
JT  - Revista brasileira de cirurgia cardiovascular : orgao oficial da Sociedade
      Brasileira de Cirurgia Cardiovascular
JID - 9104279
SB  - IM
MH  - Biomedical Research/legislation & jurisprudence/*standards
MH  - Brazil
MH  - Ethics Committees, Research/*standards
MH  - *Ethics, Research
MH  - Humans
MH  - Periodicals as Topic/*standards
EDAT- 2010/11/26 06:00
MHDA- 2011/04/07 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/04/07 06:00 [medline]
AID - S0102-76382010000300002 [pii]
AID - 10.1590/s0102-76382010000300002 [doi]
PST - ppublish
SO  - Rev Bras Cir Cardiovasc. 2010 Jul-Sep;25(3):III-IV. doi:
      10.1590/s0102-76382010000300002.


PMID- 21103634
OWN - NLM
STAT- MEDLINE
DCOM- 20110407
LR  - 20181201
IS  - 1220-0522 (Print)
IS  - 1220-0522 (Linking)
VI  - 51
IP  - 4
DP  - 2010
TI  - Placental stem cell differentiation into islets of Langerhans-like
      glucagon-secreting cells.
PG  - 733-8
AB  - BACKGROUND AND PURPOSE: For the past few years, in an attempt to find new sources
      of cells that may be used in cell therapy, numerous researchers have highlighted 
      the particular properties of mesenchymal stem cells. Mesenchymal stem cells can
      be isolated from adult tissues such as the bone marrow or adipose tissue, but
      also from other organs such as the human placenta. Our study focuses adult stem
      cells isolated from the chorionic villi in an attempt to differentiate them into 
      islets of Langerhans in order to study their differentiation potential, as a
      future background for cell therapy. EXPERIMENTAL DESIGN: Full-term placentas were
      prelevated from volunteer women that have just delivered a normal pregnancy.
      After a mechanical fragmentation of the placenta, the chorion fragments are
      transferred in a dish with dispase before the enzyme is inactivated using fetal
      calf serum. The cell suspension is filtered in order to obtain a single-cell
      suspension. After the adherence of the first cells, the proliferation rate
      increased progressively and cell morphology is kept the same for several
      passages. In order to correctly differentiate placental stem cells into
      glucagon-secreting cells, we used a culture method on a scaffold with sequential 
      exposure to different growth factors. The underlying substrate used contained
      type IV collagen, chytosan, Matrigel and laminin. Molecular biology techniques
      were carried out to investigate the gene expression of the stem cells. RESULTS:
      Our results show that exendin-4 is able to induce the differentiation of
      placental stem cells into glucagon-secreting cells. We also notice the absence of
      the insulin gene, a conclusion that may be explained by the fact that our
      phenotype is a partial one, incomplete, closer to islet cell progenitors than to 
      insulin-producing progenitors. CONCLUSIONS: The identification of the placenta as
      a valid source for stem cells has important practical advantages because it is
      easily accessible, it raises no ethical issues and cells are easily to isolate in
      a large enough number to use. The future knowledge and manipulation of the
      signaling pathways that determines the dramatic phenotype shift may provide the
      basis for efficient cell differentiation, with great impact on regenerative
      medicine and tissue engineering.
FAU - Susman, S
AU  - Susman S
AD  - Department of Histology, Iuliu Hatieganu, University of Medicine and Pharmacy,
      Cluj-Napoca, Romania. serman_s@yahoo.com
FAU - Soritau, Olga
AU  - Soritau O
FAU - Rus-Ciuca, D
AU  - Rus-Ciuca D
FAU - Tomuleasa, C
AU  - Tomuleasa C
FAU - Pop, V I
AU  - Pop VI
FAU - Mihu, Carmen Mihaela
AU  - Mihu CM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Romania
TA  - Rom J Morphol Embryol
JT  - Romanian journal of morphology and embryology = Revue roumaine de morphologie et 
      embryologie
JID - 9112454
RN  - 0 (DNA Primers)
RN  - 0 (Insulin)
RN  - 9007-92-5 (Glucagon)
SB  - IM
MH  - Adult
MH  - Adult Stem Cells/*cytology/physiology
MH  - Base Sequence
MH  - Cell Differentiation
MH  - Cell Separation
MH  - Chorionic Villi/anatomy & histology
MH  - DNA Primers/genetics
MH  - Female
MH  - Gene Expression
MH  - Glucagon/genetics/metabolism
MH  - Glucagon-Secreting Cells/*cytology/physiology
MH  - Humans
MH  - In Vitro Techniques
MH  - Insulin/genetics
MH  - Placenta/*cytology
MH  - Pregnancy
EDAT- 2010/11/26 06:00
MHDA- 2011/04/08 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/04/08 06:00 [medline]
AID - 510410733738 [pii]
PST - ppublish
SO  - Rom J Morphol Embryol. 2010;51(4):733-8.


PMID- 21103449
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 1754-9973 (Print)
IS  - 1754-9973 (Linking)
VI  - 3
IP  - 3
DP  - 2010 Nov
TI  - A Commentary on Jaffe and Hope's Proposed Ethical Framework.
PG  - 303-304
FAU - Singh, Jerome A
AU  - Singh JA
AD  - Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban,
      South Africa; Dalla Lana School of Public Health and Joint Centre for Bioethics, 
      University of Toronto, Toronto, Canada; McLaughlin-Rotman Centre for Global
      Health, University Health Network and University of Toronto, Toronto, Canada.
LA  - eng
PT  - Journal Article
DEP - 20101117
PL  - England
TA  - Public Health Ethics
JT  - Public health ethics
JID - 101463048
PMC - PMC2984561
EDAT- 2010/11/26 06:00
MHDA- 2010/11/26 06:01
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2010/11/26 06:01 [medline]
AID - 10.1093/phe/phq029 [doi]
PST - ppublish
SO  - Public Health Ethics. 2010 Nov;3(3):303-304. doi: 10.1093/phe/phq029. Epub 2010
      Nov 17.


PMID- 21103317
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20101203
LR  - 20211020
IS  - 2689-9175 (Electronic)
IS  - 1941-2789 (Linking)
VI  - 3
IP  - 11
DP  - 2010 Nov
TI  - Application of nutrigenomics in skin health: nutraceutical or cosmeceutical?
PG  - 44-6
AB  - Nutrigenomics is a growing field related to genetic testing based on the
      documentation of genetic mutations in an individual, giving us the ability to
      correct metabolic imbalances (personalized medicine) through specific dietary
      supplements or nutraceuticals. An off-shoot of nutrigenomics called dermagenetics
      (testing for selected genetic mutations related to skin health followed by
      advocating the use of either nutraceuticals or skin creams enriched by
      cosmeceuticals) is heading toward commercialization at a rapid rate by directly
      targeting the public. Although this growth represents an opportunity to explore
      the benefits of genetic advances in skin health, it is essential that the
      science, product claims, and ethical standards be critically evaluated and clear 
      national guidelines be set in order to protect the consumer.
FAU - Subbiah, M T Ravi
AU  - Subbiah MT
AD  - Department of Internal Medicine, University of Cincinnati Medical Center,
      Cincinnati, Ohio, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Aesthet Dermatol
JT  - The Journal of clinical and aesthetic dermatology
JID - 101518173
PMC - PMC2989812
EDAT- 2010/11/26 06:00
MHDA- 2010/11/26 06:01
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2010/11/26 06:01 [medline]
PST - ppublish
SO  - J Clin Aesthet Dermatol. 2010 Nov;3(11):44-6.


PMID- 21102980
OWN - NLM
STAT- MEDLINE
DCOM- 20110110
LR  - 20211020
IS  - 0161-8105 (Print)
IS  - 0161-8105 (Linking)
VI  - 33
IP  - 11
DP  - 2010 Nov
TI  - Duty to warn?-the ethics of disclosing information about possible risks
      associated with H1N1 vaccination.
PG  - 1426-7
FAU - Caplan, Arthur L
AU  - Caplan AL
LA  - eng
PT  - Comment
PT  - Editorial
PL  - United States
TA  - Sleep
JT  - Sleep
JID - 7809084
RN  - 0 (Influenza Vaccines)
SB  - IM
CON - Sleep. 2010 Nov;33(11):1428-30. PMID: 21102981
CIN - Sleep. 2010 Nov;33(11):1425. PMID: 21102979
MH  - Child
MH  - Duty to Warn/*ethics
MH  - Humans
MH  - Influenza A Virus, H1N1 Subtype/*immunology
MH  - Influenza Vaccines/*adverse effects/*immunology
MH  - Influenza, Human/*immunology
MH  - Narcolepsy/*chemically induced
MH  - Risk Factors
PMC - PMC2954688
EDAT- 2010/11/26 06:00
MHDA- 2011/01/11 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/01/11 06:00 [medline]
AID - 10.1093/sleep/33.11.1426 [doi]
PST - ppublish
SO  - Sleep. 2010 Nov;33(11):1426-7. doi: 10.1093/sleep/33.11.1426.


PMID- 21099377
OWN - NLM
STAT- MEDLINE
DCOM- 20110316
LR  - 20101124
IS  - 1533-4112 (Electronic)
IS  - 1095-0680 (Linking)
VI  - 26
IP  - 4
DP  - 2010 Dec
TI  - Electroconvulsive therapy in adolescents with the catatonia syndrome: efficacy
      and ethics.
PG  - 259-65
LID - 10.1097/YCT.0b013e3181fb3924 [doi]
AB  - OBJECTIVES: In child and adolescent psychiatry, catatonia is infrequent, but it
      is one of the most severe syndromes, characterized by the coexistence of psychic 
      and motor symptoms. In this report, we explore the therapeutic experience with
      electroconvulsive therapy (ECT) in adolescents with catatonia. METHODS: We review
      the literature (1985-2009) to clarify issues related to the use of ECT in child
      and adolescent patients with catatonia. RESULTS: Electroconvulsive therapy is
      used as second-line management after high-dose benzodiazepine trials.
      Electroconvulsive therapy is an effective, safe, and useful procedure in the
      treatment of catatonic youngsters as reported in 59 patients. Ethical issues
      regarding the use of ECT are analyzed and their implications briefly discussed in
      the light of general medical ethics. CONCLUSIONS: Electroconvulsive therapy is a 
      safe and effective treatment for catatonia in children and adolescents.
FAU - Consoli, Angele
AU  - Consoli A
AD  - Department of Child and Adolescent Psychiatry, Universite Pierre et Marie Curie, 
      APHP, Hopital Pitie-Salpetriere, CNRS UMR 7222, Institut de Systemes Intelligents
      et Robotiques Paris, France.
FAU - Benmiloud, Maha
AU  - Benmiloud M
FAU - Wachtel, Lee
AU  - Wachtel L
FAU - Dhossche, Dirk
AU  - Dhossche D
FAU - Cohen, David
AU  - Cohen D
FAU - Bonnot, Olivier
AU  - Bonnot O
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J ECT
JT  - The journal of ECT
JID - 9808943
RN  - 12794-10-4 (Benzodiazepines)
SB  - IM
MH  - Adolescent
MH  - Benzodiazepines/therapeutic use
MH  - Catatonia/psychology/*therapy
MH  - Child
MH  - Drug Resistance
MH  - Electroconvulsive Therapy/adverse effects/*ethics
MH  - Humans
MH  - Socioeconomic Factors
MH  - Treatment Outcome
EDAT- 2010/11/26 06:00
MHDA- 2011/03/17 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/03/17 06:00 [medline]
AID - 10.1097/YCT.0b013e3181fb3924 [doi]
AID - 00124509-201012000-00005 [pii]
PST - ppublish
SO  - J ECT. 2010 Dec;26(4):259-65. doi: 10.1097/YCT.0b013e3181fb3924.


PMID- 21098797
OWN - NLM
STAT- MEDLINE
DCOM- 20110506
LR  - 20110124
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 2
DP  - 2011 Feb
TI  - What do our patients understand about their trial participation? Assessing
      patients' understanding of their informed consent consultation about randomised
      clinical trials.
PG  - 74-80
LID - 10.1136/jme.2010.035485 [doi]
AB  - BACKGROUND: Ethically, informed consent regarding randomised controlled trials
      (RCTs) should be understandable to patients. The patients can then give free
      consent or decline to participate in a RCT. Little is known about what patients
      really understand in consultations about RCTs. METHODS: Cancer patients who were 
      asked to participate in a randomised trial were surveyed using a
      semi-standardised interview developed by the authors. The interview addresses
      understanding, satisfaction and needs of the patients. The sample included eight 
      patients who participated in a trial and two who declined. The data were analysed
      on the basis of Mayring's qualitative analysis. RESULTS: Patients' understanding 
      of informed consent was less developed than anticipated, especially concerning
      key elements such as randomisation, content and procedure of RCTs. Analysing the 
      result about satisfaction of the patients, most of the patients described their
      consultations as hectic and without advance notice. Health limitations due to
      cancer played a decisive role. However, most of the patients perceived their
      physician to be sympathetic. Analysing the needs of patients, they ask for a
      clear informed consent consultation with enough time and adequate advance notice.
      CONCLUSION: This study fills an important empirical research gap of what is
      ethically demanded in an RCT consultation and what is really understood by
      patients. The qualitative approach enabled us to obtain new results about cancer 
      patients' understanding of informed consent, to clarify patients' needs and to
      develop new ideas to optimise the informed consent.
FAU - Behrendt, C
AU  - Behrendt C
AD  - Department of Psychosomatic Medicine and Psychotherapy, University Hospital
      Freiburg, Freiburg, Germany.
FAU - Golz, T
AU  - Golz T
FAU - Roesler, C
AU  - Roesler C
FAU - Bertz, H
AU  - Bertz H
FAU - Wunsch, A
AU  - Wunsch A
LA  - eng
PT  - Journal Article
DEP - 20101123
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Communication
MH  - Comprehension
MH  - Decision Making
MH  - Female
MH  - Humans
MH  - Informed Consent/*ethics/psychology
MH  - Male
MH  - Middle Aged
MH  - Patient Selection/*ethics
MH  - Physician-Patient Relations
MH  - Randomized Controlled Trials as Topic/*ethics
MH  - Research Subjects/*psychology
MH  - Young Adult
EDAT- 2010/11/26 06:00
MHDA- 2011/05/07 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/05/07 06:00 [medline]
AID - jme.2010.035485 [pii]
AID - 10.1136/jme.2010.035485 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Feb;37(2):74-80. doi: 10.1136/jme.2010.035485. Epub 2010 Nov
      23.


PMID- 21098745
OWN - NLM
STAT- MEDLINE
DCOM- 20110331
LR  - 20121115
IS  - 1941-7632 (Electronic)
IS  - 1941-7640 (Linking)
VI  - 3
IP  - 6
DP  - 2010 Dec
TI  - Magnetic resonance-guided cardiac interventions using magnetic
      resonance-compatible devices: a preclinical study and first-in-man congenital
      interventions.
PG  - 585-92
LID - 10.1161/CIRCINTERVENTIONS.110.957209 [doi]
AB  - BACKGROUND: Percutaneous cardiac interventions are currently performed under
      x-ray guidance. Magnetic resonance imaging (MRI) has been used to guide
      intravascular interventions in the past, but mainly in animals. Translation of
      MR-guided interventions into humans has been limited by the lack of MR-compatible
      and safe equipment, such as MR guide wires with mechanical characteristics
      similar to standard guide wires. The aim of the present study was to evaluate the
      safety and efficacy of a newly developed MR-safe and compatible passive guide
      wire in aiding MR-guided cardiac interventions in a swine model and describe the 
      2 first-in-man solely MR-guided interventions. METHODS AND RESULTS: In the
      preclinical trial, the new MR-compatible wire aided the performance of 20
      interventions in 5 swine. These consisted of balloon dilation of nondiseased
      pulmonary and aortic valves, aortic arch, and branch pulmonary arteries. After
      ethics and regulatory authority approval, the 2 first-in-man MR-guided
      interventions were performed in a child and an adult, both with elements of
      valvar pulmonary stenosis. Catheter manipulations were monitored with real-time
      MRI sequence with interactive modification of imaging plane and slice position.
      Temporal resolution was 11 to 12 frames/s. Catheterization procedure times were
      110 and 80 minutes, respectively. Both patients had successful relief of the
      valvar stenosis and no procedural complications. CONCLUSIONS: The described
      preclinical study and case reports are encouraging that with the availability of 
      the new MR-compatible and safe guide wire, certain percutaneous cardiac
      interventions will become feasible to perform solely under MR guidance in the
      future. A clinical trial is underway in our institution.
FAU - Tzifa, Aphrodite
AU  - Tzifa A
AD  - King's College London BHF Centre, Division of Imaging Sciences, NIHR Biomedical
      Research Centre at Guy's and St Thomas' NHS Foundation Trust, London, United
      Kingdom.
FAU - Krombach, Gabriele A
AU  - Krombach GA
FAU - Kramer, Nils
AU  - Kramer N
FAU - Kruger, Sascha
AU  - Kruger S
FAU - Schutte, Adrian
AU  - Schutte A
FAU - von Walter, Matthias
AU  - von Walter M
FAU - Schaeffter, Tobias
AU  - Schaeffter T
FAU - Qureshi, Shakeel
AU  - Qureshi S
FAU - Krasemann, Thomas
AU  - Krasemann T
FAU - Rosenthal, Eric
AU  - Rosenthal E
FAU - Schwartz, Claudia A
AU  - Schwartz CA
FAU - Varma, Gopal
AU  - Varma G
FAU - Buhl, Alexandra
AU  - Buhl A
FAU - Kohlmeier, Antonia
AU  - Kohlmeier A
FAU - Bucker, Arno
AU  - Bucker A
FAU - Gunther, Rolf W
AU  - Gunther RW
FAU - Razavi, Reza
AU  - Razavi R
LA  - eng
GR  - Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101123
PL  - United States
TA  - Circ Cardiovasc Interv
JT  - Circulation. Cardiovascular interventions
JID - 101499602
SB  - IM
MH  - Animals
MH  - Cardiac Catheterization/*instrumentation
MH  - Female
MH  - Heart Defects, Congenital/*therapy
MH  - Humans
MH  - Magnetic Resonance Imaging, Interventional/*instrumentation
MH  - Pulmonary Valve Stenosis/*therapy
MH  - Swine
EDAT- 2010/11/26 06:00
MHDA- 2011/04/01 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/04/01 06:00 [medline]
AID - CIRCINTERVENTIONS.110.957209 [pii]
AID - 10.1161/CIRCINTERVENTIONS.110.957209 [doi]
PST - ppublish
SO  - Circ Cardiovasc Interv. 2010 Dec;3(6):585-92. doi:
      10.1161/CIRCINTERVENTIONS.110.957209. Epub 2010 Nov 23.


PMID- 21098176
OWN - NLM
STAT- MEDLINE
DCOM- 20110111
LR  - 20161125
IS  - 1546-3141 (Electronic)
IS  - 0361-803X (Linking)
VI  - 195
IP  - 6
DP  - 2010 Dec
TI  - CT-guided sternoclavicular joint injections: description of the procedure,
      reliability of imaging diagnosis, and short-term patient responses.
PG  - W435-9
LID - 10.2214/AJR.10.4501 [doi]
AB  - OBJECTIVE: The purpose of this study was to evaluate pain relief 20 to 30 minutes
      after diagnostic or therapeutic injections into the sternoclavicular joint and to
      compare patient outcomes based on the CT diagnosis. MATERIALS AND METHODS:
      Informed consent was obtained from each patient. Ethics approval was not
      required. Fifty patients who had CT-guided injections of corticosteroid and local
      anesthetic into their sternoclavicular joints were included in the study.
      Preinjection and 20- to 30-minute postinjection visual analog scale data were
      recorded and compared with the imaging findings agreed by consensus. Kappa
      statistics were calculated for the reliability of imaging diagnosis. The
      percentage of patients improving after joint injection was calculated, and the
      risk ratio comparing the response of patients with osteoarthritis to those
      without osteoarthritis was completed. The correlation between the severity of
      each patient's osteoarthritis and the pain response was calculated using
      Spearman's correlation coefficient. RESULTS: Sixty-six percent of the patients
      reported clinically significant pain reduction at between 20 and 30 minutes after
      injection. The proportion of patients with osteoarthritis who had a clinically
      significant response was 67% compared with 64% for patients who did not have
      osteoarthritis. This difference was not statistically or clinically significant. 
      There was no correlation between the severity of osteoarthritis and the amount of
      pain reduction (r = 0.03). The reliability of imaging diagnosis was substantial. 
      CONCLUSION: Two thirds of patients having sternoclavicular joint injections of
      corticosteroids and local anesthetics report clinically significant improvement
      regardless of the abnormalities detected on their CT images.
FAU - Peterson, Cynthia K
AU  - Peterson CK
AD  - Department of Radiology, Orthopaedic University Hospital of Balgrist,
      Forchstrasse 340, 8008 Zurich, Switzerland. cynthia.peterson@balgrist.ch
FAU - Saupe, Nadja
AU  - Saupe N
FAU - Buck, Florian
AU  - Buck F
FAU - Pfirrmann, Christian W A
AU  - Pfirrmann CW
FAU - Zanetti, Marco
AU  - Zanetti M
FAU - Hodler, Juerg
AU  - Hodler J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - AJR Am J Roentgenol
JT  - AJR. American journal of roentgenology
JID - 7708173
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Anesthetics, Local)
RN  - 0 (Contrast Media)
RN  - JR13W81H44 (Iopamidol)
SB  - IM
MH  - Adrenal Cortex Hormones/administration & dosage
MH  - Aged
MH  - Anesthetics, Local/administration & dosage
MH  - Contrast Media/administration & dosage
MH  - Female
MH  - Humans
MH  - *Injections, Intra-Articular
MH  - Iopamidol/administration & dosage
MH  - Male
MH  - Middle Aged
MH  - Osteoarthritis/*diagnostic imaging/*drug therapy
MH  - Pain Measurement
MH  - Radiography, Interventional/*methods
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Sternoclavicular Joint/*diagnostic imaging
MH  - Tomography, X-Ray Computed/*methods
MH  - Treatment Outcome
EDAT- 2010/11/26 06:00
MHDA- 2011/01/12 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/01/12 06:00 [medline]
AID - 195/6/W435 [pii]
AID - 10.2214/AJR.10.4501 [doi]
PST - ppublish
SO  - AJR Am J Roentgenol. 2010 Dec;195(6):W435-9. doi: 10.2214/AJR.10.4501.


PMID- 21097976
OWN - NLM
STAT- MEDLINE
DCOM- 20110321
LR  - 20161125
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 6
DP  - 2010 Nov
TI  - Nurses' ethical reflections on caring for people with malodorous exuding ulcers.
PG  - 777-90
LID - 10.1177/0969733010379181 [doi]
AB  - The aim of this study was to illuminate nurses' reflections on obstacles to and
      possibilities for providing care as desired by people with malodorous exuding
      ulcers. Six nurses who took part in a previous study were interviewed. The
      participants were shown an illustration with findings from a study that
      elucidated the meaning of living with malodorous exuding ulcers. They were asked 
      to reflect on the obstacles to and possibilities of providing the care desired by
      the patients. Twelve audio-recorded transcribed interviews were analysed using
      qualitative content analysis. Our interpretations of participants' reflections on
      the obstacles and possibilities while caring for such patients revealed one
      theme: striving to 'do good' and 'be good'. The obstacles were formulated as
      subthemes: experiencing clinical competence constraints, experiencing
      organizational constraints, experiencing ineffective communication, fearing
      failure, and experiencing powerlessness. The possibilities were formulated by the
      subthemes: spreading knowledge about ulcer treatments, considering wholeness, and
      creating clear channels of communication. A multiprofessional team could overcome
      the identified obstacles and provide structure, competencies, commitment and
      support to 'do good' for patients and 'be good' nurses.
FAU - Lindahl, Elisabeth
AU  - Lindahl E
AD  - Department of Nursing, Umea University, Sweden. elisabeth.lindahl@nurs.umu.se
FAU - Gilje, Fredricka
AU  - Gilje F
FAU - Norberg, Astrid
AU  - Norberg A
FAU - Soderberg, Anna
AU  - Soderberg A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Communication Barriers
MH  - Empathy
MH  - *Exudates and Transudates
MH  - Fear/ethics/psychology
MH  - Female
MH  - Holistic Health
MH  - Humans
MH  - Middle Aged
MH  - Nurse's Role/psychology
MH  - Nurse-Patient Relations/ethics
MH  - Nursing Methodology Research
MH  - Nursing Staff/education/*ethics/organization & administration/*psychology
MH  - *Odorants
MH  - Patient Advocacy/ethics/psychology
MH  - Qualitative Research
MH  - Skin Ulcer/*nursing/pathology
MH  - Surveys and Questionnaires
MH  - Sweden
MH  - Thinking
EDAT- 2010/11/26 06:00
MHDA- 2011/03/22 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/03/22 06:00 [medline]
AID - 17/6/777 [pii]
AID - 10.1177/0969733010379181 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 Nov;17(6):777-90. doi: 10.1177/0969733010379181.


PMID- 21097975
OWN - NLM
STAT- MEDLINE
DCOM- 20110321
LR  - 20191210
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 6
DP  - 2010 Nov
TI  - Ethics in independent nurse consulting: strategies for avoiding ethical
      quicksand.
PG  - 769-76
LID - 10.1177/0969733010379179 [doi]
AB  - Changes in health care have created a variety of new roles and opportunities for 
      nurses in advanced practice. One of these changes is the increasing number of
      advanced practice nurses carrying out independent consultation. Differences in
      goals between business and health care may create ethical dilemmas for nurse
      consultants. The purpose of this article is to describe possible ethical pitfalls
      that nurse consultants may encounter and strategies to prevent or solve these
      dilemmas. Three themes related to nursing codes of ethics will be discussed: the 
      duty to uphold human rights, the duty to fulfill commitments, and the duty to
      practice the profession competently.
FAU - Creel, Eileen L
AU  - Creel EL
AD  - Southeastern Louisiana University, Hammond, LA 70402, USA. ecreel@selu.edu
FAU - Robinson, Jennifer C
AU  - Robinson JC
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Advanced Practice Nursing/*ethics/organization & administration
MH  - Codes of Ethics
MH  - Confidentiality/ethics
MH  - Conflict, Psychological
MH  - *Consultants/psychology
MH  - Contract Services/ethics/organization & administration
MH  - Decision Making/ethics
MH  - Humans
MH  - Interprofessional Relations/ethics
MH  - Moral Obligations
MH  - *Nurse's Role/psychology
MH  - Patient Advocacy/ethics
MH  - Power, Psychological
MH  - Practice Guidelines as Topic
MH  - Practice Patterns, Nurses'/ethics/organization & administration
MH  - Principle-Based Ethics
MH  - Private Practice/ethics/organization & administration
MH  - Professional Competence
EDAT- 2010/11/26 06:00
MHDA- 2011/03/22 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/03/22 06:00 [medline]
AID - 17/6/769 [pii]
AID - 10.1177/0969733010379179 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 Nov;17(6):769-76. doi: 10.1177/0969733010379179.


PMID- 21097974
OWN - NLM
STAT- MEDLINE
DCOM- 20110321
LR  - 20191210
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 6
DP  - 2010 Nov
TI  - Evaluation of nursing students' training in medical law.
PG  - 759-68
LID - 10.1177/0969733010378931 [doi]
AB  - There is no co-ordinated focus on liabilities arising from nurses' medical
      interventions in terms of occupational, administrative, civil legal and criminal 
      activities. However, the Turkish Criminal Code, the Turkish Medical Ethics Code
      of Practice, and guidelines for patients' rights offer some framework for the
      relevant ethical principles and responsibilities of nurses. The aim of this study
      was to investigate the evaluation of nursing students' training in their legal
      liabilities. The sample consisted of 309 students who were taking a course
      entitled 'Nurses' legal liabilities under Turkish criminal and civil law arising 
      from medical interventions'. Data were obtained by means of self-administered
      questionnaires and McNemar's test was used to evaluate the answers. In
      conclusion, after their training, a great majority of the students demonstrated
      an improvement in terms of their percentage of correct answers relating to
      malpractice. This does not, however, mean that they will not face malpractice
      charges after graduating, but their increased awareness of the issue may
      encourage them to make more effort to reduce the risk of mistakes. It is
      recommended that nursing faculty carry out studies into medical malpractice, that
      they focus more on this subject in nursing education, and that all nursing
      schools review their curricula from the point of view of malpractice.
FAU - Kurban, Nevin Kuzu
AU  - Kurban NK
AD  - Pamukkale University Denizli School of Health, Turkey.
FAU - Savas, Halide
AU  - Savas H
FAU - Cetinkaya, Bengu
AU  - Cetinkaya B
FAU - Turan, Turkan
AU  - Turan T
FAU - Kartal, Asiye
AU  - Kartal A
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Adult
MH  - Curriculum
MH  - Education, Nursing, Baccalaureate/*organization & administration
MH  - Educational Measurement
MH  - Female
MH  - Health Services Needs and Demand
MH  - Humans
MH  - *Liability, Legal
MH  - Male
MH  - Malpractice/*legislation & jurisprudence
MH  - Nurse's Role
MH  - Nursing Education Research
MH  - Professional Competence
MH  - Program Evaluation
MH  - Socioeconomic Factors
MH  - *Students, Nursing/psychology/statistics & numerical data
MH  - Surveys and Questionnaires
MH  - Turkey
EDAT- 2010/11/26 06:00
MHDA- 2011/03/22 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/03/22 06:00 [medline]
AID - 17/6/759 [pii]
AID - 10.1177/0969733010378931 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 Nov;17(6):759-68. doi: 10.1177/0969733010378931.


PMID- 21097973
OWN - NLM
STAT- MEDLINE
DCOM- 20110321
LR  - 20101124
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 6
DP  - 2010 Nov
TI  - The ethical community consultation model as preparation for nursing research: a
      case study.
PG  - 749-58
LID - 10.1177/0969733010379176 [doi]
AB  - This article describes a case study in which community consultation was used to
      assist in the preparation of a research project on viewing self in the mirror
      after mastectomy. Breast cancer survivors, nurses, and other health care
      professionals were consulted using a variety of interactive modalities. Over a
      period of three months, pre-research planning information was obtained from
      participants. A descriptive qualitative design was used to analyze the data. The 
      ethical goals of community consultation provided the framework for dialogue and
      the synthesis of information. During this project, the potential benefits of the 
      proposed research study were explored. Possible risks to future participants were
      discussed, and recommendations for participant protection suggested. Community
      members provided insight into the legitimacy of the study. Community consultation
      is a tool that researchers may consider when designing studies.
FAU - Freysteinson, Wyona M
AU  - Freysteinson WM
AD  - Memorial Hermann Home Health and Hospice, USA. wyonaf@comcast.net
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Attitude of Health Personnel
MH  - Attitude to Health
MH  - Body Image
MH  - *Community-Based Participatory Research/ethics/organization & administration
MH  - Cooperative Behavior
MH  - Environment Design
MH  - Human Experimentation/ethics
MH  - Humans
MH  - Interior Design and Furnishings/ethics
MH  - Mastectomy/adverse effects/*psychology
MH  - *Models, Nursing
MH  - *Nursing Methodology Research/ethics/organization & administration
MH  - Patient Advocacy/ethics
MH  - *Patient Participation/methods/psychology
MH  - Patients' Rooms/ethics
MH  - Planning Techniques
MH  - Qualitative Research
MH  - *Research Design
MH  - Researcher-Subject Relations/ethics/psychology
MH  - Social Justice/ethics
MH  - Survivors/psychology
EDAT- 2010/11/26 06:00
MHDA- 2011/03/22 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/03/22 06:00 [medline]
AID - 17/6/749 [pii]
AID - 10.1177/0969733010379176 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 Nov;17(6):749-58. doi: 10.1177/0969733010379176.


PMID- 21097972
OWN - NLM
STAT- MEDLINE
DCOM- 20110321
LR  - 20191210
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 6
DP  - 2010 Nov
TI  - Ethical concerns of nursing reviewers: an international survey.
PG  - 741-8
LID - 10.1177/0969733010379177 [doi]
AB  - Editors of scientific literature rely heavily on peer reviewers to evaluate the
      integrity of research conduct and validity of findings in manuscript submissions.
      The purpose of this study was to describe the ethical concerns of reviewers of
      nursing journals. This descriptive cross-sectional study was an anonymous online 
      survey. The findings reported here were part of a larger investigation of
      experiences of reviewers. Fifty-two editors of nursing journals (six outside the 
      USA) agreed to invite their review panels to participate. A 69-item forced-choice
      and open-ended survey developed by the authors based on the literature was pilot 
      tested with 18 reviewers before being entered into SurveyMonkey(TM). A total of
      1675 reviewers responded with useable surveys. Six questions elicited responses
      about ethical issues, such as conflict of interest, protection of human research 
      participants, plagiarism, duplicate publication, misrepresentation of data and
      'other'. The reviewers indicated whether they had experienced such a concern and 
      notified the editor, and how satisfied they were with the outcome. They provided 
      specific examples. Approximately 20% of the reviewers had experienced various
      ethical dilemmas. Although the majority reported their concerns to the editor,
      not all did so, and not all were satisfied with the outcomes. The most commonly
      reported concern perceived was inadequate protection of human participants. The
      least common was plagiarism, but this was most often reported to the editor and
      least often led to a satisfactory outcome. Qualitative responses at the end of
      the survey indicate this lack of satisfaction was most commonly related to
      feedback provided on resolution by the editor. The findings from this study
      suggest several areas that editors should note, including follow up with
      reviewers when they identify ethical concerns about a manuscript.
FAU - Broome, Marion
AU  - Broome M
AD  - Indiana University, Indianapolis, IN 46202, USA. mbroome@iupui.edu
FAU - Dougherty, Molly C
AU  - Dougherty MC
FAU - Freda, Margaret C
AU  - Freda MC
FAU - Kearney, Margaret H
AU  - Kearney MH
FAU - Baggs, Judith G
AU  - Baggs JG
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
CIN - Nurs Ethics. 2011 Nov;18(6):862. PMID: 22128100
MH  - Animal Rights
MH  - *Attitude of Health Personnel
MH  - Communication
MH  - Conflict of Interest
MH  - Cross-Sectional Studies
MH  - Deception
MH  - Duplicate Publications as Topic
MH  - Editorial Policies
MH  - Female
MH  - Human Experimentation/ethics
MH  - Humans
MH  - Interprofessional Relations/ethics
MH  - Male
MH  - Nursing Methodology Research
MH  - Nursing Research/*ethics
MH  - Patient Rights/ethics
MH  - Peer Review, Research/*ethics
MH  - Periodicals as Topic/*ethics
MH  - Plagiarism
MH  - Qualitative Research
MH  - Surveys and Questionnaires
EDAT- 2010/11/26 06:00
MHDA- 2011/03/22 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/03/22 06:00 [medline]
AID - 17/6/741 [pii]
AID - 10.1177/0969733010379177 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 Nov;17(6):741-8. doi: 10.1177/0969733010379177.


PMID- 21097970
OWN - NLM
STAT- MEDLINE
DCOM- 20110321
LR  - 20211203
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 6
DP  - 2010 Nov
TI  - Cultural safety and the socioethical nurse.
PG  - 715-25
LID - 10.1177/0969733010379296 [doi]
AB  - This article explores the social and ethical elements of cultural safety and
      combines them in a model of culturally safe practice that should be of interest
      and relevance for nurses, nurse educators and nurse ethicists in other cultures. 
      To achieve this, the article briefly reviews and critiques the main underpinnings
      of the concept from its origins and development in New Zealand, describes its
      sociocultural and sociopolitical elements, and provides an in-depth exploration
      of the key socioethical elements. Finally, a model is presented to illustrate the
      strong connection between the social and ethical components of cultural safety
      that combine to produce culturally safe practice through the activities of a
      'socioethical' nurse.
FAU - Woods, Martin
AU  - Woods M
AD  - Massey University, New Zealand. m.woods@massey.ac.nz
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Attitude of Health Personnel
MH  - Cultural Competency/education/*ethics/organization & administration
MH  - Cultural Diversity
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Models, Nursing
MH  - Native Hawaiian or Other Pacific Islander/ethnology/legislation & jurisprudence
MH  - New Zealand
MH  - *Nurse's Role/psychology
MH  - Nurse-Patient Relations/*ethics
MH  - Patient Rights/ethics/legislation & jurisprudence
MH  - Philosophy, Nursing
MH  - Politics
MH  - Power, Psychological
MH  - Prejudice
MH  - Safety Management/*ethics/organization & administration
MH  - Social Justice/ethics
MH  - Transcultural Nursing/education/*ethics/organization & administration
MH  - Trust/psychology
MH  - Vulnerable Populations/ethnology/legislation & jurisprudence
EDAT- 2010/11/26 06:00
MHDA- 2011/03/22 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/03/22 06:00 [medline]
AID - 17/6/715 [pii]
AID - 10.1177/0969733010379296 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 Nov;17(6):715-25. doi: 10.1177/0969733010379296.


PMID- 21097969
OWN - NLM
STAT- MEDLINE
DCOM- 20110321
LR  - 20101124
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 6
DP  - 2010 Nov
TI  - Nurse-focused ethical solutions to problems in organ transplantation.
PG  - 705-14
LID - 10.1177/0969733010378933 [doi]
AB  - Technological developments in recent years have brought about a rapid increase in
      the number and variety of organ transplants, leading to problems in finding
      enough organs to meet the need. Organ transplantation has also become a
      particularly significant issue in medical ethics, especially regarding the
      question of how and from whom organs are procured. Many methods have been tried
      in order to solve these problems and discussed from an ethical perspective. This 
      study investigates the Spanish, Belgian and Iranian approaches to solving the
      organ procurement problem. The Spanish model, which is based on persuading
      patients and their relatives, is ethically less problematic and is also an
      improved version of the model applied in Turkey. This study argues that an ideal 
      solution can be found without disregarding ethical rules. In particular, nurses
      can contribute by helping to run the system more efficiently. The principal aim
      of this article is to demonstrate the contribution of nurses to solving the
      current organ procurement problem in Turkey and offer some reflections on what
      can be done to improve the efficiency of the system.
FAU - Ertin, Hakan
AU  - Ertin H
AD  - Department of Medical Ethics and History of Medicine, Istanbul University,
      Turkey. hakanertin@gmail.com
FAU - Harmanci, Arzu Kader
AU  - Harmanci AK
FAU - Mahmutoglu, Fatih Selami
AU  - Mahmutoglu FS
FAU - Basagaoglu, Ibrahim
AU  - Basagaoglu I
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Brain Death/diagnosis/legislation & jurisprudence
MH  - Communication
MH  - Efficiency, Organizational
MH  - Family/psychology
MH  - Humans
MH  - Informed Consent/ethics/legislation & jurisprudence/psychology
MH  - Models, Nursing
MH  - Models, Organizational
MH  - Needs Assessment/ethics/organization & administration
MH  - *Nurse's Role/psychology
MH  - Nurse-Patient Relations/ethics
MH  - Problem Solving/*ethics
MH  - Professional-Family Relations/ethics
MH  - Tissue and Organ Procurement/*ethics/organization & administration
MH  - Turkey
EDAT- 2010/11/26 06:00
MHDA- 2011/03/22 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/03/22 06:00 [medline]
AID - 17/6/705 [pii]
AID - 10.1177/0969733010378933 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 Nov;17(6):705-14. doi: 10.1177/0969733010378933.


PMID- 21097968
OWN - NLM
STAT- MEDLINE
DCOM- 20110321
LR  - 20211203
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 6
DP  - 2010 Nov
TI  - Unresolved pain in children: a relational ethics perspective.
PG  - 695-704
LID - 10.1177/0969733010378932 [doi]
AB  - It is considered the right of children to have their pain managed effectively.
      Yet, despite extensive research findings, policy guidelines and practice standard
      recommendations for the optimal management of paediatric pain, clinical practices
      remain inadequate. Empirical evidence definitively shows that unrelieved pain in 
      children has only harmful consequences, with no benefits. Contributing factors
      identified in this undermanaged pain include the significant role of nurses.
      Nursing attitudes and beliefs about children's pain experiences, the
      relationships nurses share with children who are suffering, and knowledge
      deficits in pain management practices are all shown to impact unresolved pain in 
      children. In this article, a relational ethics perspective is used to explore the
      need for nurses to engage in authentic relationships with children who are
      experiencing pain, and to use evidence-based practices to manage that pain in
      order for this indefensible suffering of children to end.
FAU - Olmstead, Deborah L
AU  - Olmstead DL
AD  - University of Alberta, Canada. deboraho@ualberta.ca
FAU - Scott, Shannon D
AU  - Scott SD
FAU - Austin, Wendy J
AU  - Austin WJ
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Attitude of Health Personnel
MH  - Child
MH  - Child Advocacy/*ethics
MH  - Clinical Competence
MH  - Ethical Relativism
MH  - Evidence-Based Practice/education/ethics
MH  - Guideline Adherence/ethics/organization & administration
MH  - Health Services Needs and Demand/ethics
MH  - Humans
MH  - Moral Obligations
MH  - Nurse's Role/psychology
MH  - Nurse-Patient Relations/ethics
MH  - Nursing Assessment/ethics
MH  - Pain/diagnosis/nursing/*prevention & control/psychology
MH  - Pain Measurement/ethics/nursing
MH  - Pediatric Nursing/education/*ethics/organization & administration
MH  - Practice Guidelines as Topic
MH  - Translational Research, Biomedical/ethics
MH  - Treatment Failure
EDAT- 2010/11/26 06:00
MHDA- 2011/03/22 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/03/22 06:00 [medline]
AID - 17/6/695 [pii]
AID - 10.1177/0969733010378932 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 Nov;17(6):695-704. doi: 10.1177/0969733010378932.


PMID- 21097967
OWN - NLM
STAT- MEDLINE
DCOM- 20110321
LR  - 20191210
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 6
DP  - 2010 Nov
TI  - Images of a 'good nurse' presented by teaching staff.
PG  - 687-94
LID - 10.1177/0969733010378930 [doi]
AB  - Nursing is at the same time a vocation, a profession and a job. By nature,
      nursing is a moral endeavor, and being a 'good nurse' is an issue and an
      aspiration for professionals. The aim of our qualitative research project carried
      out with 18 nurse teachers at a university nursing school in Brazil was to
      identify the ethical image of nursing. In semistructured interviews the
      participants were asked to choose one of several pictures, to justify their
      choice and explain what they meant by an ethical nurse. Five different
      perspectives were revealed: good nurses fulfill their duties correctly; they are 
      proactive patient advocates; they are prepared and available to welcome others as
      persons; they are talented, competent, and carry out professional duties
      excellently; and they combine authority with power sharing in patient care. The
      results point to a transition phase from a historical introjection of religious
      values of obedience and service to a new sense of a secular, proactive,
      scientific and professional identity.
FAU - de Araujo Sartorio, Natalia
AU  - de Araujo Sartorio N
AD  - University of Sao Paulo, Brazil. natsartorio@gmail.com
FAU - Pavone Zoboli, Elma Lourdes Campos
AU  - Pavone Zoboli EL
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - *Attitude of Health Personnel
MH  - Brazil
MH  - Character
MH  - Cooperative Behavior
MH  - *Ethics, Nursing
MH  - *Faculty, Nursing
MH  - Humans
MH  - *Medicine in the Arts
MH  - *Nurse's Role/psychology
MH  - Nurse-Patient Relations
MH  - Nursing Methodology Research
MH  - Patient Advocacy/ethics
MH  - Philosophy, Nursing
MH  - Power, Psychological
MH  - *Professional Competence
MH  - Qualitative Research
MH  - Social Perception
MH  - Surveys and Questionnaires
MH  - Virtues
EDAT- 2010/11/26 06:00
MHDA- 2011/03/22 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/03/22 06:00 [medline]
AID - 17/6/687 [pii]
AID - 10.1177/0969733010378930 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 Nov;17(6):687-94. doi: 10.1177/0969733010378930.


PMID- 21097965
OWN - NLM
STAT- MEDLINE
DCOM- 20110321
LR  - 20101124
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 6
DP  - 2010 Nov
TI  - The ethics of research ethics committees.
PG  - 683-4
LID - 10.1177/0969733010384241 [doi]
FAU - Gallagher, Ann
AU  - Gallagher A
LA  - eng
PT  - Editorial
PT  - Introductory Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - *Ethical Review
MH  - Ethics Committees, Research/*ethics/organization & administration
MH  - Humans
MH  - Nursing Research/ethics
MH  - *Peer Review, Research/ethics/methods
MH  - *Periodicals as Topic/ethics
EDAT- 2010/11/26 06:00
MHDA- 2011/03/22 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/03/22 06:00 [medline]
AID - 17/6/683 [pii]
AID - 10.1177/0969733010384241 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 Nov;17(6):683-4. doi: 10.1177/0969733010384241.


PMID- 21097940
OWN - NLM
STAT- MEDLINE
DCOM- 20110506
LR  - 20110124
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 2
DP  - 2011 Feb
TI  - Scientific evidence and best patient care practices should guide the ethics of
      Lyme disease activism.
PG  - 68-73
LID - 10.1136/jme.2009.032896 [doi]
AB  - Johnson and Stricker published an opinion piece in the Journal of Medical Ethics 
      presenting their perspective on the 2008 agreement between the Infectious
      Diseases Society of America (IDSA) and the Connecticut Attorney General with
      regard to the 2006 IDSA treatment guideline for Lyme disease. Their writings
      indicate that these authors hold unconventional views of a relatively common
      tick-transmitted bacterial infection caused by the spirochete Borrelia
      burgdorferi. Therefore, it should come as no surprise that their opinions would
      clash with the IDSA's evidence-based guidelines for the diagnosis and treatment
      of Lyme disease. Their allegations of conflict of interest against the IDSA
      resemble those made against the National Institutes of Health, the Food and Drug 
      Administration and the Centers for Disease Control and Prevention in 2000, which 
      were found to be baseless. It is the responsibility of all physicians and medical
      scientists to stand up to antiscientific, baseless and unethical attacks on those
      who support an evidence-based approach to caring for patients.
FAU - Auwaerter, Paul G
AU  - Auwaerter PG
AD  - Division of Infectious Diseases, Department of Medicine, The Johns Hopkins
      Medical Institutions, Baltimore, Maryland, USA.
FAU - Bakken, Johan S
AU  - Bakken JS
FAU - Dattwyler, Raymond J
AU  - Dattwyler RJ
FAU - Dumler, J Stephen
AU  - Dumler JS
FAU - Halperin, John J
AU  - Halperin JJ
FAU - McSweegan, Edward
AU  - McSweegan E
FAU - Nadelman, Robert B
AU  - Nadelman RB
FAU - O'Connell, Susan
AU  - O'Connell S
FAU - Sood, Sunil K
AU  - Sood SK
FAU - Weinstein, Arthur
AU  - Weinstein A
FAU - Wormser, Gary P
AU  - Wormser GP
LA  - eng
PT  - Journal Article
DEP - 20101121
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Anti-Bacterial Agents/therapeutic use
MH  - *Borrelia burgdorferi
MH  - *Conflict of Interest
MH  - Evidence-Based Medicine/ethics/*standards
MH  - Health Policy/legislation & jurisprudence
MH  - Humans
MH  - *Lyme Disease/diagnosis/drug therapy
MH  - Practice Guidelines as Topic/*standards
MH  - Quality of Health Care
MH  - Societies, Medical/*ethics/legislation & jurisprudence
MH  - United States
EDAT- 2010/11/26 06:00
MHDA- 2011/05/07 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/05/07 06:00 [medline]
AID - jme.2009.032896 [pii]
AID - 10.1136/jme.2009.032896 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Feb;37(2):68-73. doi: 10.1136/jme.2009.032896. Epub 2010 Nov
      21.


PMID- 21097794
OWN - NLM
STAT- MEDLINE
DCOM- 20110222
LR  - 20110113
IS  - 1468-2044 (Electronic)
IS  - 0003-9888 (Linking)
VI  - 96
IP  - 2
DP  - 2011 Feb
TI  - 'This House believes that we have gone too far in granting young people the
      responsibility for making decisions about their own healthcare': record of a
      debate held in the Ethics and Law session of the RCPCH Annual Meeting, York 2009.
PG  - 123-6
LID - 10.1136/adc.2010.184333 [doi]
FAU - Larcher, Vic
AU  - Larcher V
AD  - Clinical Ethics Service, Department of Adolescent Medicine, Great Ormond Street
      Hospital for Children, London, UK. larchv@gosh.nhs.uk
FAU - Jones, Alun Elias
AU  - Jones AE
FAU - Brierley, Joe
AU  - Brierley J
FAU - Mepani, Bharti
AU  - Mepani B
FAU - Willsher, Alex
AU  - Willsher A
FAU - Linton, Sarah
AU  - Linton S
FAU - Hamilton-Foad, Courtney
AU  - Hamilton-Foad C
FAU - Mistry, Ravi
AU  - Mistry R
FAU - Raman, Haima
AU  - Raman H
FAU - Murphy, Hollie
AU  - Murphy H
FAU - Beesley, Phillipa
AU  - Beesley P
LA  - eng
PT  - Journal Article
DEP - 20101119
PL  - England
TA  - Arch Dis Child
JT  - Archives of disease in childhood
JID - 0372434
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Decision Making/*ethics
MH  - Dissent and Disputes
MH  - England
MH  - Humans
MH  - Mental Competency
MH  - *Patient Participation/legislation & jurisprudence
EDAT- 2010/11/26 06:00
MHDA- 2011/02/23 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/02/23 06:00 [medline]
AID - adc.2010.184333 [pii]
AID - 10.1136/adc.2010.184333 [doi]
PST - ppublish
SO  - Arch Dis Child. 2011 Feb;96(2):123-6. doi: 10.1136/adc.2010.184333. Epub 2010 Nov
      19.


PMID- 21097482
OWN - NLM
STAT- MEDLINE
DCOM- 20110411
LR  - 20101124
IS  - 1532-2092 (Electronic)
IS  - 1099-5129 (Linking)
VI  - 12
IP  - 12
DP  - 2010 Dec
TI  - Remote monitoring for active cardiovascular implantable electronic devices: a
      European survey.
PG  - 1778-80
LID - 10.1093/europace/euq399 [doi]
AB  - This survey sampled today's European practices in the use of remote monitoring
      (RM) for the follow-up of active cardiovascular implantable electronic devices.
      Eighty-five per cent of the responding centres are currently using RM. For the
      majority, RM is expected to increase importantly within 5 years, and it has
      already led to a new organization of care based on dedicated allied professionals
      and/or the creation of RM units. There are still major limitations for the
      development of RM, such as ethical and legal aspects, reimbursement issues, and
      the lack of specific national- and European-updated guidelines which need to be
      informed.
FAU - Halimi, Franck
AU  - Halimi F
AD  - Centre Medico-Chirurgical Parly 2, 21 rue Moxouris, 78150 Le Chesnay, France.
      franck.halimi@club-internet.fr
FAU - Cantu, Francesco
AU  - Cantu F
CN  - European Heart Rhythm Association (EHRA) Scientific Initiatives Committee (SIC)
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Europace
JT  - Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal 
      of the working groups on cardiac pacing, arrhythmias, and cardiac cellular
      electrophysiology of the European Society of Cardiology
JID - 100883649
SB  - IM
MH  - Data Collection
MH  - Death, Sudden, Cardiac/prevention & control
MH  - *Defibrillators, Implantable
MH  - Europe
MH  - Follow-Up Studies
MH  - Heart Failure/physiopathology/*therapy
MH  - Humans
MH  - *Pacemaker, Artificial
MH  - *Remote Sensing Technology
EDAT- 2010/11/26 06:00
MHDA- 2011/04/13 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/04/13 06:00 [medline]
AID - euq399 [pii]
AID - 10.1093/europace/euq399 [doi]
PST - ppublish
SO  - Europace. 2010 Dec;12(12):1778-80. doi: 10.1093/europace/euq399.


PMID- 21095996
OWN - NLM
STAT- MEDLINE
DCOM- 20110330
LR  - 20200928
IS  - 2375-7477 (Print)
IS  - 2375-7477 (Linking)
VI  - 2010
DP  - 2010
TI  - Assessment of moral judgment of BME and other health sciences students.
PG  - 2963-6
LID - 10.1109/IEMBS.2010.5626266 [doi]
AB  - The accreditation criteria for engineering programs require that the curriculum
      introduce students to the ethical, social, economics and safety issues arising
      from the practice of engineering. This paper presents the assessment of moral
      judgment of biomedical engineering, dentistry and biochemistry students through
      the standardized Defining Issues Test (DIT). Results show that college students, 
      as most active members of society, remain at a stage of moral development where
      morality is still predominantly dictated by outside forces. It is expected that
      after formal Ethics studies, students will score higher in the last stages of
      moral development, where laws are regarded as social contracts and moral
      reasoning is based on universal ethical principles.
FAU - Monzon, Jorge E
AU  - Monzon JE
AD  - Universidad Nacional del Nordeste, Corrientes, Argentina.
      jemonzon@exa.unne.edu.ar
FAU - Ariasgago, Olga L
AU  - Ariasgago OL
FAU - Monzon-Wyngaard, Alvaro
AU  - Monzon-Wyngaard A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Annu Int Conf IEEE Eng Med Biol Soc
JT  - Annual International Conference of the IEEE Engineering in Medicine and Biology
      Society. IEEE Engineering in Medicine and Biology Society. Annual International
      Conference
JID - 101763872
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biochemistry/education
MH  - Bioethics
MH  - Biomedical Engineering/*education/*methods
MH  - Education, Dental/methods
MH  - Ethics, Research
MH  - Humans
MH  - Judgment/ethics
MH  - Moral Development
MH  - Morals
MH  - Students
MH  - Surveys and Questionnaires
MH  - Universities
EDAT- 2010/11/26 06:00
MHDA- 2011/03/31 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/03/31 06:00 [medline]
AID - 10.1109/IEMBS.2010.5626266 [doi]
PST - ppublish
SO  - Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:2963-6. doi:
      10.1109/IEMBS.2010.5626266.


PMID- 21095559
OWN - NLM
STAT- MEDLINE
DCOM- 20110321
LR  - 20101124
IS  - 1558-3481 (Electronic)
IS  - 0899-5885 (Linking)
VI  - 22
IP  - 4
DP  - 2010 Dec
TI  - Cultural, ethical, and spiritual implications of natural disasters from the
      survivors' perspective.
PG  - 515-22
LID - 10.1016/j.ccell.2010.09.005 [doi]
AB  - Cultural, ethical, and spiritual implications of disaster depend on various
      factors. The impact of a disaster on a particular culture depends on the people
      in that culture and the strength and resilience of the culture. Disasters may
      slow cultural development; however, typically the customs, beliefs, and value
      systems remain the same even if the outward expressions of culture change.
      Critical to survivors is the implication of aid that is culturally sensitive.
      Ethical questions and dilemmas associated with disasters and their management are
      profound. Adhering to ethical principles does not solve all of the issues related
      to disaster management, but awareness of their utility is important. People
      affected by a disaster may not be capable of responding to human rights
      violations, so it is the first responders who must be cognizant of their
      responsibility to protect the victims' dignity and rights. Ethical treatment of
      survivors entails a crucial blend of knowledge about ethnic culture, religious
      beliefs, and human rights. A strong awareness of ethical principles is merely a
      beginning step to well-informed decision making in disaster situations. The
      literature also suggests that during a crisis, spirituality helps victims to
      cope. Important to any catastrophic event is the understanding that every
      disaster creates unique circumstances that require relief responses tailored to
      the specific situation.
CI  - Published by Elsevier Inc.
FAU - Varghese, Shainy B
AU  - Varghese SB
AD  - University of Houston Victoria, Sugar Land, Texas 77479, USA. vargheses@uhv.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Crit Care Nurs Clin North Am
JT  - Critical care nursing clinics of North America
JID - 8912620
MH  - Adaptation, Psychological
MH  - *Attitude to Health/ethnology
MH  - Confidentiality/ethics
MH  - Cultural Competency
MH  - Disaster Planning/*organization & administration
MH  - *Disasters
MH  - Emigration and Immigration
MH  - *Ethics
MH  - Grief
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Needs Assessment/ethics/organization & administration
MH  - Principle-Based Ethics
MH  - Resource Allocation/ethics/organization & administration
MH  - Security Measures
MH  - Social Values
MH  - *Spirituality
MH  - Survivors/*psychology
EDAT- 2010/11/26 06:00
MHDA- 2011/03/22 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/03/22 06:00 [medline]
AID - S0899-5885(10)00063-8 [pii]
AID - 10.1016/j.ccell.2010.09.005 [doi]
PST - ppublish
SO  - Crit Care Nurs Clin North Am. 2010 Dec;22(4):515-22. doi:
      10.1016/j.ccell.2010.09.005.


PMID- 21095558
OWN - NLM
STAT- MEDLINE
DCOM- 20110321
LR  - 20101124
IS  - 1558-3481 (Electronic)
IS  - 0899-5885 (Linking)
VI  - 22
IP  - 4
DP  - 2010 Dec
TI  - Catastrophic events and older adults.
PG  - 501-13
LID - 10.1016/j.ccell.2010.10.003 [doi]
AB  - The plight of older adults during catastrophic events is a societal concern.
      Older persons have an increased prevalence of cognitive disorders, chronic
      illnesses, and mobility problems that limit their ability to cope. These
      disorders may result in a lack of mental capacity and the ability to discern when
      they should evacuate or resolve problems encountered during a catastrophe. Some
      older persons may have limited transportation options, and many of the elderly
      survivors are at increased risk for abuse, neglect, and exploitation.
      Recommendations for future catastrophic events include the development of a
      federal tracking system for elders and other vulnerable adults, the designation
      of separate shelter areas for elders and other vulnerable adults, and involvement
      of gerontological professionals in all aspects of emergency preparedness and care
      delivery, including training of frontline workers. Preparation through preevent
      planning that includes region-specific social services, medical and public health
      resources, volunteers, and facilities for elders and vulnerable adults is
      critical. Elders need to be protected from abuse and fraud during catastrophic
      events. A public health triage system for elders and other vulnerable populations
      in pre- and postdisaster situations is useful, and disaster preparedness is
      paramount. Communities and members of safety and rescue teams must address
      ethical issues before an event. When older adults are involved, consideration
      needs to be given to triage decision making, transporting those who are immobile,
      the care of older adults who receive palliative care, and the equitable
      distribution of resources. Nurses are perfectly equipped with the skills,
      knowledge, and training needed to plan and implement disaster preparedness
      programs. In keeping with the tradition of Florence Nightingale, nurses can
      assume several crucial roles in disaster preparedness for older adults. Nurses
      possess the ability to participate and lead community policy development, serve
      on rescue teams, perform patient assessments, and deliver care. Nurses are
      crucial to well-planned and executed programs for catastrophic events that affect
      older adults. Also, all health care providers involved must be aware of the
      physical and psychological ramifications of disaster relief. The health and
      resilience of disaster-relief teams depend on paying attention to signs and
      symptoms of posttraumatic stress disorder and seeking appropriate treatment
      should it occur.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Cloyd, Elizabeth
AU  - Cloyd E
AD  - Harris County Hospital District, Houston, TX 77054, USA. beth_cloyd@hchd.tmc.edu
FAU - Dyer, Carmel B
AU  - Dyer CB
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Crit Care Nurs Clin North Am
JT  - Critical care nursing clinics of North America
JID - 8912620
MH  - Aged
MH  - Benchmarking
MH  - Cognition Disorders/prevention & control
MH  - Delirium/prevention & control
MH  - Dementia/prevention & control
MH  - Depression/prevention & control
MH  - Disaster Planning/*organization & administration
MH  - Elder Abuse/prevention & control
MH  - Geriatric Nursing/ethics/*organization & administration
MH  - Geriatrics/organization & administration
MH  - Health Services Needs and Demand
MH  - Health Services for the Aged/organization & administration
MH  - Humans
MH  - Stress Disorders, Post-Traumatic/prevention & control
MH  - Transportation of Patients
MH  - Triage
MH  - Vulnerable Populations
EDAT- 2010/11/26 06:00
MHDA- 2011/03/22 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/03/22 06:00 [medline]
AID - S0899-5885(10)00067-5 [pii]
AID - 10.1016/j.ccell.2010.10.003 [doi]
PST - ppublish
SO  - Crit Care Nurs Clin North Am. 2010 Dec;22(4):501-13. doi:
      10.1016/j.ccell.2010.10.003.


PMID- 21095554
OWN - NLM
STAT- MEDLINE
DCOM- 20110321
LR  - 20141120
IS  - 1558-3481 (Electronic)
IS  - 0899-5885 (Linking)
VI  - 22
IP  - 4
DP  - 2010 Dec
TI  - Cultural, ethical, and spiritual competencies of health care providers responding
      to a catastrophic event.
PG  - 455-64
LID - 10.1016/j.ccell.2010.09.001 [doi]
AB  - Compassion is a language that is understood across cultures, religions, and
      nations. Being compassionate and empathetic is a basic responsibility of health
      care providers responding to disasters. Compassion and empathy cannot be
      operationalized unless providers show culturally competent, ethically right, and 
      spiritually caring behavior. In addition to being accepting of cultures other
      than their own, providers must read literature and familiarize themselves with
      the predominant cultures of the affected population. Ethically right decision
      making is essentially an act of balancing the risks and benefits to the entire
      society. Spiritual care is an important dimension of total health, and therefore 
      recognition and resolution of the spiritual needs of disaster victims is an
      essential role of health care providers. Disaster management is teamwork and
      therefore requires that health care providers draw on the expertise and support
      of other team members; coordinating efforts with local religious, social
      governmental organizations, and NGOs to deal with the intangible effects of the
      cultural and spiritual impact of a disaster and to prevent further demoralization
      of the affected community is imperative. Disasters occur, and the only thing that
      can ameliorate their devastating effects is to improve disaster preparedness and 
      respond collectively and courageously to every catastrophic event.
CI  - Published by Elsevier Inc.
FAU - Jose, Mini M
AU  - Jose MM
AD  - University of Texas Medical Branch, Galveston, 77555, USA. mmjose@utmb.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Crit Care Nurs Clin North Am
JT  - Critical care nursing clinics of North America
JID - 8912620
MH  - Algorithms
MH  - *Clinical Competence
MH  - *Cultural Competency/education/ethics/organization & administration
MH  - Disaster Planning/*organization & administration
MH  - Emergency Medical Services/ethics/organization & administration
MH  - Global Health
MH  - Health Care Rationing/ethics/organization & administration
MH  - *Health Personnel/education/ethics/organization & administration/psychology
MH  - Health Services Needs and Demand/ethics/organization & administration
MH  - Humans
MH  - Practice Guidelines as Topic
MH  - Principle-Based Ethics
MH  - Professional Role/psychology
MH  - *Spirituality
MH  - Triage/ethics/organization & administration
EDAT- 2010/11/26 06:00
MHDA- 2011/03/22 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/03/22 06:00 [medline]
AID - S0899-5885(10)00059-6 [pii]
AID - 10.1016/j.ccell.2010.09.001 [doi]
PST - ppublish
SO  - Crit Care Nurs Clin North Am. 2010 Dec;22(4):455-64. doi:
      10.1016/j.ccell.2010.09.001.


PMID- 21095045
OWN - NLM
STAT- MEDLINE
DCOM- 20111102
LR  - 20110712
IS  - 1532-2793 (Electronic)
IS  - 0260-6917 (Linking)
VI  - 31
IP  - 6
DP  - 2011 Aug
TI  - Strategies used by experienced versus novice practice teachers to enact their
      role with community nurse students.
PG  - 558-63
LID - 10.1016/j.nedt.2010.10.033 [doi]
AB  - This study offers an original analysis of how community nurse practice teachers
      learn to enact their role. A constructivist grounded theory approach was applied 
      to a study of thirty community nurse practice teachers. Practice teachers were
      interviewed using a lightly structured interview approach following ethical
      approval. The study found that practice teachers considered relationships and
      nurturance to be of central importance. This led to emphasis being placed on
      providing experience for students and formative assessment. A number of key
      differences between the way novice and experienced practice teachers saw
      themselves functioning were discovered. These differences were theorised to
      explain the finding that novice practice teachers were much more likely to
      identify students as experiencing major difficulties than experienced practice
      teachers. It was discovered that practice teachers learn to enact their role
      within a socio-cultural context drawing upon a transformation approach to
      learning. This approach becomes firmly established over a period of approximately
      three years and is at odds with the current emphasis on competency based
      transmission models of learning.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Sayer, Lynn
AU  - Sayer L
AD  - Programme Leader Community Health Nursing, Brunel University, Uxbridge, UB8 3PH, 
      UK. lynn.sayer@brunel.ac.uk
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20101120
PL  - Scotland
TA  - Nurse Educ Today
JT  - Nurse education today
JID - 8511379
MH  - Community Health Nursing/*education
MH  - Cultural Characteristics
MH  - *Faculty, Nursing
MH  - Humans
MH  - Interprofessional Relations
MH  - *Nurse's Role
MH  - Nursing Education Research
MH  - Nursing Methodology Research
MH  - Qualitative Research
MH  - Social Environment
MH  - Students, Nursing
MH  - Teaching/*methods
EDAT- 2010/11/26 06:00
MHDA- 2011/11/04 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/04/12 00:00 [received]
PHST- 2010/10/11 00:00 [revised]
PHST- 2010/10/31 00:00 [accepted]
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
AID - S0260-6917(10)00219-4 [pii]
AID - 10.1016/j.nedt.2010.10.033 [doi]
PST - ppublish
SO  - Nurse Educ Today. 2011 Aug;31(6):558-63. doi: 10.1016/j.nedt.2010.10.033. Epub
      2010 Nov 20.


PMID- 21095043
OWN - NLM
STAT- MEDLINE
DCOM- 20110406
LR  - 20161020
IS  - 1578-1283 (Electronic)
IS  - 0213-9111 (Linking)
VI  - 24 Suppl 1
DP  - 2010 Dec
TI  - [Grounding public health policies in ethics and economic efficiency. SESPAS
      report 2010].
PG  - 120-7
LID - 10.1016/j.gaceta.2010.09.011 [doi]
AB  - OBJECTIVES: In recent times, various voices in Spain have questioned public
      health policies as an assault to personal freedom. The present article aims to
      respond to these voices with ethical and economic arguments. METHODS: The scope
      and characteristics of this current of opinion are described. Then, starting with
      John Stuart Mill, the ethical principles of non-maleficence, beneficence,
      personal autonomy and justice, as well as related concepts taken from economic
      efficiency, such as externalities, monopoly, incomplete and asymmetric
      information, agency relationship, public goods and adverse selection, are
      discussed. A short mention is made of equity in economics, the welfare state and 
      public health systems. The justification for paternalist actions by the state, as
      well as limits to these actions, are briefly discussed. CONCLUSION: Respect for
      individual freedom does not exclude the implementation of public health actions
      but rather demands the adoption of such policies. If these actions comply with
      certain conditions, they do not limit individual freedom but rather serve to
      protect it.
CI  - Copyright (c) 2010 SESPAS. Published by Elsevier Espana. All rights reserved.
FAU - Ramiro Aviles, Miguel A
AU  - Ramiro Aviles MA
AD  - Instituto de Derechos Humanos Bartolome de las Casas, Universidad Carlos III,
      Madrid, Espana.
FAU - Lobo, Felix
AU  - Lobo F
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
TT  - La justificacion de las politicas de salud publica desde la etica y la eficiencia
      economica. Informe SESPAS 2010.
DEP - 20101120
PL  - Spain
TA  - Gac Sanit
JT  - Gaceta sanitaria
JID - 8901623
SB  - IM
MH  - Health Policy/*economics
MH  - Humans
MH  - Public Health/*economics/*ethics
MH  - Spain
EDAT- 2010/11/26 06:00
MHDA- 2011/04/07 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/03/15 00:00 [received]
PHST- 2010/09/13 00:00 [revised]
PHST- 2010/09/14 00:00 [accepted]
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/04/07 06:00 [medline]
AID - S0213-9111(10)00254-2 [pii]
AID - 10.1016/j.gaceta.2010.09.011 [doi]
PST - ppublish
SO  - Gac Sanit. 2010 Dec;24 Suppl 1:120-7. doi: 10.1016/j.gaceta.2010.09.011. Epub
      2010 Nov 20.


PMID- 21094848
OWN - NLM
STAT- MEDLINE
DCOM- 20110307
LR  - 20131121
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 42
IP  - 9
DP  - 2010 Nov
TI  - Assessment of bioequivalence of a generic cyclosporine (Equoral) by a prospective
      randomized controlled trial on allogeneic stem cell transplant recipients.
PG  - 3735-8
LID - 10.1016/j.transproceed.2010.06.019 [doi]
AB  - INTRODUCTION: Bioequivalence of Equoral has been suggested by measurements of
      pharmacokinetic parameters in healthy volunteers and in stable renal transplant
      recipients, but not study in allogeneic stem cell transplant (ASCT) recipients.
      The aim of our study was to compare the pharmacokinetics and safety of Equoral to
      Neoral solution among ASCT recipients. PATIENTS AND METHODS: Our open-label,
      two-way crossover, randomized controlled trial compared Equoral versus Neoral
      solutions in ASCT recipients. The 30 enrolled patients from June 2007 to November
      2008 had a 7 to 14-day duration of the test period. A 10-point blood sampling
      from 0 to 12 hours measured Cmax (extent of absorption), tmax (rate of
      absorption) and AUC(0-12h) (area under the concentration-time curve) calculated
      by the linear trapezoid rule. The study protocol was approved by the ethics
      committee. RESULTS: Median age was 26 years (range = 6-47). The mean
      pharmacokinetic features were: AUC(0-12h): Equoral 4162 +/- 1231 ng.mL/h vs
      Neoral 4370 +/- 1059 ng.mL/h (P = .50); Cmax: Equoral 821 +/- 244 ng/mL vs Neoral
      834 +/- 298 ng/mL (P = .86); and tmax: 105 minutes for both formulations.
      Comparable toxicities and rates of graft-versus-host disease were recorded in
      both groups. CONCLUSION: We suggest that Equoral and Neoral solution can be
      considered interchangeable in ASCT recipients.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Tarek, B O
AU  - Tarek BO
AD  - Centre National de Greffe de Moelle Osseuse, Tunis, Tunisia.
FAU - Nadia, B F
AU  - Nadia BF
FAU - Anis, K
AU  - Anis K
FAU - Saloua, L
AU  - Saloua L
FAU - Abderrahmane, A
AU  - Abderrahmane A
FAU - Lamia, T
AU  - Lamia T
FAU - Amel, L
AU  - Amel L
FAU - Mohamed, L
AU  - Mohamed L
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - 0 (Drugs, Generic)
RN  - 0 (Immunosuppressive Agents)
RN  - 83HN0GTJ6D (Cyclosporine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Area Under Curve
MH  - Child
MH  - Cross-Over Studies
MH  - Cyclosporine/adverse effects/blood/*pharmacokinetics
MH  - Drugs, Generic/adverse effects/*pharmacokinetics
MH  - Graft vs Host Disease/etiology/prevention & control
MH  - Humans
MH  - Immunosuppressive Agents/adverse effects/blood/*pharmacokinetics
MH  - Middle Aged
MH  - Prospective Studies
MH  - *Stem Cell Transplantation/adverse effects
MH  - Therapeutic Equivalency
MH  - Transplantation, Homologous
MH  - Treatment Outcome
MH  - Tunisia
MH  - Young Adult
EDAT- 2010/11/26 06:00
MHDA- 2011/03/08 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/02/17 00:00 [received]
PHST- 2010/06/18 00:00 [accepted]
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/03/08 06:00 [medline]
AID - S0041-1345(10)01274-1 [pii]
AID - 10.1016/j.transproceed.2010.06.019 [doi]
PST - ppublish
SO  - Transplant Proc. 2010 Nov;42(9):3735-8. doi: 10.1016/j.transproceed.2010.06.019.


PMID- 21094558
OWN - NLM
STAT- MEDLINE
DCOM- 20111118
LR  - 20151119
IS  - 1872-6054 (Electronic)
IS  - 0168-8510 (Linking)
VI  - 101
IP  - 2
DP  - 2011 Jul
TI  - Psychosocial factors associated with the prescription of generic drugs.
PG  - 178-84
LID - 10.1016/j.healthpol.2010.10.015 [doi]
AB  - OBJECTIVE: To evaluate factors associated with "Generic drug prescription" (GDP) 
      behaviour in Spain using the ASE (Attitude, Social Influence, Self-Efficacy)
      Model. METHODS: General Practitioners were sent a validated and anonymous
      questionnaire measuring the ASE and Motivation variables for GDP and their
      generic drug prescription percentage. Most (n=486; 61.98%) responded to this
      cross-sectional survey. The mean scores and the 95% confidence intervals (95% CI)
      were calculated. A binary logistic regression was used to identify the variables 
      that best predict GDP behaviour. RESULTS: The main advantages and motivations for
      GDP were "saving money" and "protecting professional ethics". The greatest social
      influences were "doctors' personal preferences" and "authorities' pressure". GDP 
      accounted for a scarce 15% of the total prescription. ASE and Motivation items
      were the best predictors: they explain 25% of being a 'high prescriber'. The
      highest prescribers were paediatricians (OR=5.07), workers in rural settings
      (OR=3.68) and professionals with high Motivation (OR=1.17) and Attitude (OR=1.11)
      scores. CONCLUSIONS: GDP percentage is very low compared with other countries.
      Interventions to modify the Attitudes of Primary Care doctors towards generic
      drugs should be implemented. Better informed patients, longer doctor appointment 
      times and more varied dosage forms of generic drugs would also facilitate
      improvements in GDP.
CI  - Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Rodriguez-Calvillo, Javier A
AU  - Rodriguez-Calvillo JA
AD  - Department of Medicine, Preventive Medicine and Public Health Area, University of
      Oviedo, C/Julian Claveria s/n, 33006 Oviedo, Asturias, Spain. rcalvillo@uniovi.es
FAU - Lana, Alberto
AU  - Lana A
FAU - Cueto, Antonio
AU  - Cueto A
FAU - Markham, Wolfgang A
AU  - Markham WA
FAU - Lopez, Maria Luisa
AU  - Lopez ML
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101120
PL  - Ireland
TA  - Health Policy
JT  - Health policy (Amsterdam, Netherlands)
JID - 8409431
RN  - 0 (Drugs, Generic)
MH  - *Drug Prescriptions
MH  - *Drugs, Generic
MH  - Female
MH  - General Practitioners/*psychology
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Models, Psychological
MH  - Models, Theoretical
MH  - Spain
MH  - Surveys and Questionnaires
EDAT- 2010/11/26 06:00
MHDA- 2011/12/13 00:00
CRDT- 2010/11/25 06:00
PHST- 2010/05/18 00:00 [received]
PHST- 2010/10/13 00:00 [revised]
PHST- 2010/10/15 00:00 [accepted]
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0168-8510(10)00309-X [pii]
AID - 10.1016/j.healthpol.2010.10.015 [doi]
PST - ppublish
SO  - Health Policy. 2011 Jul;101(2):178-84. doi: 10.1016/j.healthpol.2010.10.015. Epub
      2010 Nov 20.


PMID- 21094467
OWN - NLM
STAT- MEDLINE
DCOM- 20110307
LR  - 20120509
IS  - 1878-1632 (Electronic)
IS  - 1529-9430 (Linking)
VI  - 10
IP  - 12
DP  - 2010 Dec
TI  - Dural repair with four spinal sealants: focused review of the manufacturers'
      inserts and the current literature.
PG  - 1065-8
LID - 10.1016/j.spinee.2010.09.017 [doi]
AB  - BACKGROUND CONTEXT: Deliberate or traumatic dural fistulas are typically
      augmented by a "sealant" or "fibrin glue" to enhance the strength of dural
      closure. PURPOSE: Little is known about the risks and complications associated
      with two specific "sealants" and two specific "fibrin glues" used for dural
      closure. STUDY DESIGN/SETTING: Review of the manufacturers' inserts and a focused
      review of the literature concerning the pros and cons for two "sealants"
      (DuraSeal [Confluent Surgical Inc., Waltham, MA, USA] and BioGlue [Cryolife,
      Kennesaw, GA, USA]) and two "fibrin glues" (EVICEL [Johnson and Johnson Wound
      Management, Ethicon Inc., Somerville, NJ, USA] and Tisseel [fibrin sealant;
      Baxter International Inc., Westlake Village, CA, USA]) were assessed. PATIENT
      SAMPLE: A focused review of the literature using four different "sealants" or
      "fibrin glues" was performed. OUTCOME MEASURES: Documentation of
      persistent/recurrent postoperative cerebrospinal fluid fistulas was an end point 
      for failure for the four different "sealants" and "fibrin glues." METHODS:
      Manufacturers' inserts and a focused review of the literature concerning the
      relative safety and efficacy of two "sealants" (DuraSeal and BioGlue) and two
      "fibrin glues" (EVICEL and Tisseel) used to augment dural closure were assessed. 
      RESULTS: Although DuraSeal is approved by the Federal Drug Administration (FDA)
      for intracranial and spinal application, two instances of paralysis are described
      in the literature. BioGlue is classified by the manufacturer as neurotoxic.
      EVICEL, one of the "fibrin glues," appeared in just two animal studies, whereas
      Tisseel, the other "fibrin glue," has been used in many large clinical series
      without adverse events. CONCLUSION: Despite the lack of FDA approval, Tisseel
      (fibrin glue) has seen wide adoption in "off-label" use. DuraSeal, which is FDA
      approved, was associated with two instances of paralysis. Alternatively, BioGlue 
      was described as neurotoxic even by the manufacturer.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Epstein, Nancy E
AU  - Epstein NE
AD  - The Leo M. Davidoff Department of Neurological Surgery, The Albert Einstein
      College of Medicine, Bronx 10461, NY, USA. dch3@columbia.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Spine J
JT  - The spine journal : official journal of the North American Spine Society
JID - 101130732
RN  - 0 (Bio-glue)
RN  - 0 (Fibrin Tissue Adhesive)
RN  - 0 (Proteins)
RN  - 0 (Resins, Synthetic)
RN  - 0 (Tissue Adhesives)
RN  - 80294-23-1 (Dura-Seal)
SB  - IM
CIN - Spine J. 2011 Oct;11(10):983; author reply 983-4. PMID: 22005082
CIN - Spine J. 2012 Mar;12(3):279; author reply 280-1. PMID: 22469306
MH  - Dura Mater/*surgery
MH  - Fibrin Tissue Adhesive/adverse effects/therapeutic use
MH  - Humans
MH  - Proteins/adverse effects/therapeutic use
MH  - Resins, Synthetic/adverse effects/therapeutic use
MH  - Tissue Adhesives/adverse effects/*therapeutic use
EDAT- 2010/11/26 06:00
MHDA- 2011/03/08 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/04/26 00:00 [received]
PHST- 2010/08/08 00:00 [revised]
PHST- 2010/09/12 00:00 [accepted]
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/03/08 06:00 [medline]
AID - S1529-9430(10)01224-6 [pii]
AID - 10.1016/j.spinee.2010.09.017 [doi]
PST - ppublish
SO  - Spine J. 2010 Dec;10(12):1065-8. doi: 10.1016/j.spinee.2010.09.017.


PMID- 21094339
OWN - NLM
STAT- MEDLINE
DCOM- 20110329
LR  - 20101124
IS  - 1879-2057 (Electronic)
IS  - 0001-4575 (Linking)
VI  - 43
IP  - 1
DP  - 2011 Jan
TI  - Spying or steering? Views of parents of young novice drivers on the use and
      ethics of driver-monitoring technologies.
PG  - 412-20
LID - 10.1016/j.aap.2010.09.011 [doi]
AB  - In-vehicle technologies that document driving practices have the potential to
      enhance the driving safety of young drivers, but their installation depends
      largely on their parents' willingness and raises ethical dilemmas. This study
      investigated, using closed and open-ended questions, the views of 906 parents of 
      young drivers in Israel regarding their willingness to install such a technology,
      and their conceptions of social norms and ethical issues associated with the
      technology and of factors that would encourage or discourage parents to adopt it.
      Most believed parents should feel morally obligated to install it. When cost was 
      not a consideration, most said they would, and believed other parents would be
      willing to install the technology. Fewer (about half) expressed willingness to
      install it after being told about its estimated cost. Monetary cost was rated as 
      a barrier to install it by about half. Environmental considerations were viewed
      as an incentive. Parents who supported the installation believed it would serve
      as a trigger for parent-young driver communication but those who did not thought 
      it would erode trust in the parent-young driver relationship. Most said parents
      should have access to the monitoring data. Policy implications regarding issues
      of privacy and resources for parents are discussed.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Guttman, Nurit
AU  - Guttman N
AD  - Department of Communication, Tel Aviv University, Israel. guttman@post.tau.ac.il
FAU - Lotan, Tsippy
AU  - Lotan T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101023
PL  - England
TA  - Accid Anal Prev
JT  - Accident; analysis and prevention
JID - 1254476
SB  - IM
MH  - Accidents, Traffic/prevention & control/psychology
MH  - Adolescent
MH  - *Artificial Intelligence
MH  - Attitude
MH  - Authoritarianism
MH  - Automobile Driving/*education/*psychology
MH  - Automobiles/economics/*ethics
MH  - *Dangerous Behavior
MH  - Feedback
MH  - Female
MH  - Humans
MH  - Israel
MH  - Male
MH  - Morals
MH  - *Parent-Child Relations
MH  - Parenting/*psychology
MH  - Protective Devices/economics/*ethics
MH  - Remote Sensing Technology/economics/*ethics/*instrumentation
MH  - Social Values
MH  - Trust
EDAT- 2010/11/26 06:00
MHDA- 2011/03/30 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/07/15 00:00 [received]
PHST- 2010/09/10 00:00 [revised]
PHST- 2010/09/23 00:00 [accepted]
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/03/30 06:00 [medline]
AID - S0001-4575(10)00274-5 [pii]
AID - 10.1016/j.aap.2010.09.011 [doi]
PST - ppublish
SO  - Accid Anal Prev. 2011 Jan;43(1):412-20. doi: 10.1016/j.aap.2010.09.011. Epub 2010
      Oct 23.


PMID- 21093602
OWN - NLM
STAT- MEDLINE
DCOM- 20110328
LR  - 20220129
IS  - 1096-3634 (Electronic)
IS  - 1084-9521 (Linking)
VI  - 22
IP  - 1
DP  - 2011 Feb
TI  - Molecular pharmacology in a simple model system: implicating MAP kinase and
      phosphoinositide signalling in bipolar disorder.
PG  - 105-13
LID - 10.1016/j.semcdb.2010.11.002 [doi]
AB  - Understanding the mechanisms of drug action has been the primary focus for
      pharmacological researchers, traditionally using rodent models. However,
      non-sentient model systems are now increasingly being used as an alternative
      approach to better understand drug action or targets. One of these model systems,
      the social amoeba Dictyostelium, enables the rapid ablation or over-expression of
      genes, and the subsequent use of isogenic cell culture for the analysis of cell
      signalling pathways in pharmacological research. The model also supports an
      increasingly important ethical view of research, involving the reduction,
      replacement and refinement of animals in biomedical research. This review
      outlines the use of Dictyostelium in understanding the pharmacological action of 
      two commonly used bipolar disorder treatments (valproic acid and lithium). Both
      of these compounds regulate mitogen activated protein (MAP) kinase and inositol
      phospholipid-based signalling by unknown means. Analysis of the molecular
      pathways targeted by these drugs in Dictyostelium and translation of discoveries 
      to animal systems has helped to further understand the molecular mechanisms of
      these bipolar disorder treatments.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Ludtmann, Marthe H R
AU  - Ludtmann MH
AD  - Centre for Biomedical Sciences, School of Biological Sciences, Royal Holloway
      University of London, Egham, UK.
FAU - Boeckeler, Katrina
AU  - Boeckeler K
FAU - Williams, Robin S B
AU  - Williams RS
LA  - eng
GR  - G0900775/1/NC3RS_/National Centre for the Replacement, Refinement and Reduction
      of Animals in Research/United Kingdom
GR  - 082640/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20101118
PL  - England
TA  - Semin Cell Dev Biol
JT  - Seminars in cell & developmental biology
JID - 9607332
RN  - 0 (Phosphatidylinositols)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Animals
MH  - Bipolar Disorder/*drug therapy/*metabolism
MH  - Humans
MH  - MAP Kinase Signaling System
MH  - Mitogen-Activated Protein Kinases/metabolism
MH  - Models, Biological
MH  - Phosphatidylinositols/metabolism
MH  - *Signal Transduction
PMC - PMC3032892
EDAT- 2010/11/26 06:00
MHDA- 2011/03/29 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/10/27 00:00 [received]
PHST- 2010/11/10 00:00 [revised]
PHST- 2010/11/11 00:00 [accepted]
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/03/29 06:00 [medline]
AID - S1084-9521(10)00193-X [pii]
AID - 10.1016/j.semcdb.2010.11.002 [doi]
PST - ppublish
SO  - Semin Cell Dev Biol. 2011 Feb;22(1):105-13. doi: 10.1016/j.semcdb.2010.11.002.
      Epub 2010 Nov 18.


PMID- 21093250
OWN - NLM
STAT- MEDLINE
DCOM- 20110803
LR  - 20110415
IS  - 1879-0429 (Electronic)
IS  - 0958-1669 (Linking)
VI  - 22
IP  - 2
DP  - 2011 Apr
TI  - Food applications of bacterial cell wall hydrolases.
PG  - 164-71
LID - 10.1016/j.copbio.2010.10.012 [doi]
AB  - Bacterial cell wall hydrolases (BCWHs) display a remarkable structural and
      functional diversity that offers perspectives for novel food applications,
      reaching beyond those of the archetype BCWH and established biopreservative hen
      egg white lysozyme. Insights in BCWHs from bacteriophages to animals have
      provided concepts for tailoring BCWHs to target specific pathogens or spoilage
      bacteria, or, conversely, to expand their working range to Gram-negative
      bacteria. Genetically modified foods expressing BCWHs in situ showed successful, 
      but face regulatory and ethical concerns. An interesting spin-off development is 
      the use of cell wall binding domains of bacteriophage BCWHs for detection and
      removal of foodborne pathogens. Besides for improving food safety or stability,
      BCWHs may also find use as functional food ingredients with specific health
      effects.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Callewaert, Lien
AU  - Callewaert L
AD  - Centre for Food and Microbial Technology, Katholieke Universiteit Leuven,
      Kasteelpark Arenberg 23 box 2457, B-3001 Leuven, Belgium.
FAU - Walmagh, Maarten
AU  - Walmagh M
FAU - Michiels, Chris W
AU  - Michiels CW
FAU - Lavigne, Rob
AU  - Lavigne R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20101117
PL  - England
TA  - Curr Opin Biotechnol
JT  - Current opinion in biotechnology
JID - 9100492
RN  - EC 3.- (Hydrolases)
SB  - IM
MH  - Animals
MH  - Bacteria/*metabolism
MH  - Cell Wall/*metabolism
MH  - Food Microbiology/*methods
MH  - Gram-Negative Bacteria/metabolism
MH  - Hydrolases/*metabolism
MH  - Substrate Specificity
EDAT- 2010/11/26 06:00
MHDA- 2011/08/04 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/10/07 00:00 [received]
PHST- 2010/10/19 00:00 [revised]
PHST- 2010/10/22 00:00 [accepted]
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
AID - S0958-1669(10)00200-4 [pii]
AID - 10.1016/j.copbio.2010.10.012 [doi]
PST - ppublish
SO  - Curr Opin Biotechnol. 2011 Apr;22(2):164-71. doi: 10.1016/j.copbio.2010.10.012.
      Epub 2010 Nov 17.


PMID- 21092331
OWN - NLM
STAT- MEDLINE
DCOM- 20110418
LR  - 20211020
IS  - 1475-925X (Electronic)
IS  - 1475-925X (Linking)
VI  - 9
DP  - 2010 Nov 24
TI  - Quantitative pinch stimulator for exploring evoked nociceptive responses: a pilot
      study.
PG  - 79
LID - 10.1186/1475-925X-9-79 [doi]
AB  - BACKGROUND: A mechanical noxious stimulator is useful for studies of pain, both
      for clinic and basic research. We propose to use a pinch stimulator that can not 
      only generate a quantitative, reproducible noxious pinch but also simultaneously 
      provide a synchronous external trigger signal, which is essential for acquisition
      of evoked potentials. METHODS: For ethical considerations, audible and visual
      aids were incorporated so that pinch force could be regulated within a
      predetermined level. Reproducibility of the nociceptive responses evoked by this 
      device was validated. The device was constructed with a simple circuit, and the
      element build-in was delicately selected for the minimum required to produce
      evoked potentials. RESULTS: The magnitude of the force output is linearly
      proportional to the volts produced by the device (i.e., during the pinch).
      Increases in force correspond to increases in the number of action potentials
      induced. CONCLUSIONS: This device may be useful for studying the mechanisms of
      nociceptive signal processing in the brain through application of reproducible,
      noxious pinch stimuli.
FAU - Chen, Chih-Ping
AU  - Chen CP
AD  - Institute of Biomedical Engineering, College of Engineering and College of
      Medicine, National Taiwan University, Taipei, Taiwan.
FAU - Liao, Wen-Li
AU  - Liao WL
FAU - Tseng, Yi-Li
AU  - Tseng YL
FAU - Lu, Pen-Li
AU  - Lu PL
FAU - Lo, Yu-Chun
AU  - Lo YC
FAU - Chen, You-Yin
AU  - Chen YY
FAU - Jaw, Fu-Shan
AU  - Jaw FS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101124
PL  - England
TA  - Biomed Eng Online
JT  - Biomedical engineering online
JID - 101147518
SB  - IM
MH  - Animals
MH  - *Electrical Equipment and Supplies
MH  - *Evoked Potentials
MH  - Male
MH  - Pain/*physiopathology
MH  - Pilot Projects
MH  - Rats
MH  - Rats, Wistar
MH  - Somatosensory Cortex/physiology
PMC - PMC3009631
EDAT- 2010/11/26 06:00
MHDA- 2011/04/19 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/06/21 00:00 [received]
PHST- 2010/11/24 00:00 [accepted]
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/04/19 06:00 [medline]
AID - 1475-925X-9-79 [pii]
AID - 10.1186/1475-925X-9-79 [doi]
PST - epublish
SO  - Biomed Eng Online. 2010 Nov 24;9:79. doi: 10.1186/1475-925X-9-79.


PMID- 21092187
OWN - NLM
STAT- MEDLINE
DCOM- 20110218
LR  - 20220410
IS  - 1750-1172 (Electronic)
IS  - 1750-1172 (Linking)
VI  - 5
DP  - 2010 Nov 22
TI  - Fabry disease.
PG  - 30
LID - 10.1186/1750-1172-5-30 [doi]
AB  - Fabry disease (FD) is a progressive, X-linked inherited disorder of
      glycosphingolipid metabolism due to deficient or absent lysosomal
      alpha-galactosidase A activity. FD is pan-ethnic and the reported annual
      incidence of 1 in 100,000 may underestimate the true prevalence of the disease.
      Classically affected hemizygous males, with no residual alpha-galactosidase A
      activity may display all the characteristic neurological (pain), cutaneous
      (angiokeratoma), renal (proteinuria, kidney failure), cardiovascular
      (cardiomyopathy, arrhythmia), cochleo-vestibular and cerebrovascular (transient
      ischemic attacks, strokes) signs of the disease while heterozygous females have
      symptoms ranging from very mild to severe. Deficient activity of lysosomal
      alpha-galactosidase A results in progressive accumulation of
      globotriaosylceramide within lysosomes, believed to trigger a cascade of cellular
      events. Demonstration of marked alpha-galactosidase A deficiency is the
      definitive method for the diagnosis of hemizygous males. Enzyme analysis may
      occasionnally help to detect heterozygotes but is often inconclusive due to
      random X-chromosomal inactivation so that molecular testing (genotyping) of
      females is mandatory. In childhood, other possible causes of pain such as
      rheumatoid arthritis and 'growing pains' must be ruled out. In adulthood,
      multiple sclerosis is sometimes considered. Prenatal diagnosis, available by
      determination of enzyme activity or DNA testing in chorionic villi or cultured
      amniotic cells is, for ethical reasons, only considered in male fetuses.
      Pre-implantation diagnosis is possible. The existence of atypical variants and
      the availability of a specific therapy singularly complicate genetic counseling. 
      A disease-specific therapeutic option - enzyme replacement therapy using
      recombinant human alpha-galactosidase A - has been recently introduced and its
      long term outcome is currently still being investigated. Conventional management 
      consists of pain relief with analgesic drugs, nephroprotection (angiotensin
      converting enzyme inhibitors and angiotensin receptors blockers) and
      antiarrhythmic agents, whereas dialysis or renal transplantation are available
      for patients experiencing end-stage renal failure. With age, progressive damage
      to vital organ systems develops and at some point, organs may start to fail in
      functioning. End-stage renal disease and life-threatening cardiovascular or
      cerebrovascular complications limit life-expectancy of untreated males and
      females with reductions of 20 and 10 years, respectively, as compared to the
      general population. While there is increasing evidence that long-term enzyme
      therapy can halt disease progression, the importance of adjunctive therapies
      should be emphasized and the possibility of developing an oral therapy drives
      research forward into active site specific chaperones.
FAU - Germain, Dominique P
AU  - Germain DP
AD  - University of Versailles - St Quentin en Yvelines, Faculte de Medecine Paris -
      Ile de France Ouest (PIFO), 78035 Versailles, France.
      dominique.germain@rpc.aphp.fr
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20101122
PL  - England
TA  - Orphanet J Rare Dis
JT  - Orphanet journal of rare diseases
JID - 101266602
RN  - EC 3.2.1.22 (alpha-Galactosidase)
SB  - IM
MH  - Adult
MH  - Cardiovascular Diseases/genetics/physiopathology
MH  - Child
MH  - Child, Preschool
MH  - Chromosomes, Human, X/genetics
MH  - Enzyme Replacement Therapy
MH  - *Fabry Disease/diagnosis/genetics/physiopathology/therapy
MH  - Female
MH  - Humans
MH  - Kidney/pathology
MH  - Kidney Diseases/genetics/pathology/physiopathology
MH  - Male
MH  - Randomized Controlled Trials as Topic
MH  - alpha-Galactosidase/analysis/*genetics/therapeutic use
PMC - PMC3009617
EDAT- 2010/11/26 06:00
MHDA- 2011/02/22 06:00
CRDT- 2010/11/25 06:00
PHST- 2009/04/01 00:00 [received]
PHST- 2010/11/22 00:00 [accepted]
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/02/22 06:00 [medline]
AID - 1750-1172-5-30 [pii]
AID - 10.1186/1750-1172-5-30 [doi]
PST - epublish
SO  - Orphanet J Rare Dis. 2010 Nov 22;5:30. doi: 10.1186/1750-1172-5-30.


PMID- 21091982
OWN - NLM
STAT- MEDLINE
DCOM- 20120711
LR  - 20120203
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 26
IP  - 3
DP  - 2012 Mar
TI  - Milk banks through the lens of Muslim scholars: one text in two contexts.
PG  - 117-27
LID - 10.1111/j.1467-8519.2010.01844.x [doi]
AB  - When Muslims thought of establishing milk banks, religious reservations were
      raised. These reservations were based on the concept that women's milk creates
      'milk kinship' believed to impede marriage in Islamic Law. This type of kinship
      is, however, a distinctive phenomenon of Arab tradition and relatively unknown in
      Western cultures. This article is a pioneer study which fathoms out the
      contemporary discussions of Muslim scholars on this issue. The main focus here is
      a religious guideline (fatwa) issued in 1983, referred to in this article as 'one
      text', by the Egyptian scholar Yusuf al-Qaradawi who saw no religious problem in 
      establishing or using these banks. After a number of introductory remarks on the 
      'Western' phenomenon of milk banks and the 'Islamic' phenomenon of 'milk
      kinship', this article analyses the fatwa of al-Qaradawi 'one text' and
      investigates the 'two contexts' in which this fatwa was discussed, namely, the
      context of the Muslim world and that of Muslim minorities living in the West. The
      first context led to rejecting the fatwa and refusing to introduce the milk
      banking system in the Muslim world. The second context led to accepting this
      system and thus allowing Muslims living in the West to donate and receive milk
      from these banks. Besides its relevance to specialists in the fields of Islamic
      studies, anthropology and medical ethics, this article will also be helpful to
      physicians and nurses who deal with patients of Islamic background.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Ghaly, Mohammed
AU  - Ghaly M
AD  - Leiden University, Faculty of Humanities, Leiden Institute for Religious Studies,
      The Netherlands. m.ghaly@hum.leidenuniv.nl
LA  - eng
PT  - Journal Article
DEP - 20101123
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - *Arabs
MH  - Cultural Diversity
MH  - Female
MH  - Humans
MH  - Incest/*ethnology/legislation & jurisprudence
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - *Islam
MH  - Milk Banks/*ethics/legislation & jurisprudence
MH  - *Religion and Medicine
EDAT- 2010/11/26 06:00
MHDA- 2012/07/12 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2012/07/12 06:00 [medline]
AID - 10.1111/j.1467-8519.2010.01844.x [doi]
PST - ppublish
SO  - Bioethics. 2012 Mar;26(3):117-27. doi: 10.1111/j.1467-8519.2010.01844.x. Epub
      2010 Nov 23.


PMID- 21091581
OWN - NLM
STAT- MEDLINE
DCOM- 20110729
LR  - 20151119
IS  - 1440-1754 (Electronic)
IS  - 1034-4810 (Linking)
VI  - 47
IP  - 3
DP  - 2011 Mar
TI  - The Australian cerebral palsy research study--protocol for a national
      collaborative study investigating genomic and clinical associations with cerebral
      palsy.
PG  - 99-110
LID - 10.1111/j.1440-1754.2010.01896.x [doi]
AB  - AIM: Previous studies have proposed a link between the presence of specific
      single nucleotide polymorphisms (SNPs) and cerebral palsy and the majority of
      these associations remain to be confirmed or rejected by prospective studies with
      sufficient statistical power. Prior studies have also given little attention to
      the interaction of genomic characteristics and clinical risk factors. METHODS:
      This paper describes the design of a prospective case-control study to test these
      genetic associations in conjunction with more stringent data collection in
      respect to clinical features associated with pregnancy, particularly maternal
      infection. Here we consider the ethical requirements, our hypothesis that genetic
      susceptibility modifies the risk of cerebral palsy in the presence of perinatal
      environmental triggers, a priori primary and secondary aims, power calculations, 
      participant recruitment strategies, data linkage, sampling methods of genetic
      material and subsequent SNP analysis, collection of clinical data and the
      proposed final statistical analysis.
CI  - (c) 2010 The Authors. Journal of Paediatrics and Child Health (c) 2010
      Paediatrics and Child Health Division (Royal Australasian College of Physicians).
FAU - O'Callaghan, Michael E
AU  - O'Callaghan ME
AD  - Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive 
      Health, Robinson Institute, The University of Adelaide, Adelaide, South
      Australia, Australia. michael.ocallaghan@student.adelaide.edu.au
FAU - MacLennan, Alastair H
AU  - MacLennan AH
FAU - Gibson, Catherine S
AU  - Gibson CS
FAU - McMichael, Gai L
AU  - McMichael GL
FAU - Haan, Eric A
AU  - Haan EA
FAU - Broadbent, Jessica
AU  - Broadbent J
FAU - Priest, Kevin
AU  - Priest K
FAU - Goldwater, Paul N
AU  - Goldwater PN
FAU - Dekker, Gustaaf A
AU  - Dekker GA
CN  - Australian Collaborative Cerebral Palsy Research Group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101121
PL  - Australia
TA  - J Paediatr Child Health
JT  - Journal of paediatrics and child health
JID - 9005421
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Adolescent
MH  - Australia
MH  - Case-Control Studies
MH  - Cerebral Palsy/*etiology/*genetics
MH  - Child
MH  - Child, Preschool
MH  - *Cooperative Behavior
MH  - DNA
MH  - Female
MH  - Humans
MH  - Polymorphism, Single Nucleotide
MH  - Pregnancy
MH  - Pregnancy Complications/*genetics
MH  - Premature Birth/genetics
MH  - Prospective Studies
MH  - *Research Design
MH  - Risk Factors
MH  - Surveys and Questionnaires
MH  - Systemic Inflammatory Response Syndrome/genetics
MH  - Thrombophilia/genetics
IR  - Raghavendra P
FIR - Raghavendra, Parimala
IR  - Walker L
FIR - Walker, Lloyd
IR  - Chan A
FIR - Chan, Annabelle
IR  - van Essen P
FIR - van Essen, Phillipa
IR  - Johnston L
FIR - Johnston, Leanne
IR  - Delacy M
FIR - Delacy, Michael
IR  - McIntyre S
FIR - McIntyre, Sarah
IR  - Bink M
FIR - Bink, Michael
IR  - Reddihough D
FIR - Reddihough, Dinah
IR  - Reid S
FIR - Reid, Sue
IR  - Oats J
FIR - Oats, Jeremy
IR  - Bunyard J
FIR - Bunyard, Julie
IR  - Blair E
FIR - Blair, Eve
IR  - Watson L
FIR - Watson, Linda
EDAT- 2010/11/26 06:00
MHDA- 2011/07/30 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/07/30 06:00 [medline]
AID - 10.1111/j.1440-1754.2010.01896.x [doi]
PST - ppublish
SO  - J Paediatr Child Health. 2011 Mar;47(3):99-110. doi:
      10.1111/j.1440-1754.2010.01896.x. Epub 2010 Nov 21.


PMID- 21090949
OWN - NLM
STAT- MEDLINE
DCOM- 20110408
LR  - 20101124
IS  - 1466-187X (Electronic)
IS  - 0142-159X (Linking)
VI  - 32
IP  - 12
DP  - 2010
TI  - Initial knowledge of medical professionalism among Chinese medical students.
PG  - 961-70
LID - 10.3109/0142159X.2010.497827 [doi]
AB  - BACKGROUND: Initial knowledge of professionalism among medical students is
      particularly important for designing effective professionalism curricula and for 
      studying the change in the knowledge of professionalism. AIM: The study examined 
      first-semester medical students' initial knowledge of important attributes of
      good doctors. METHODS: Mixed methods were used to examine initial knowledge among
      first-semester students from a Chinese medical college. We used an open-ended
      survey to identify attributes of good doctors and grounded theory analysis to
      find emergent themes. We also used a close-ended survey to solicit students'
      responses to 50 attributes of good doctors and explorative and confirmatory
      factor analysis to examine underlying factors. RESULTS: 973 students completed
      the open-ended survey while 1730 students completed the close-ended survey.
      Through grounded theory analysis, 24 subthemes and three themes that include
      Ethics, Skill, and Person, emerged from the data. Explorative and confirmatory
      factor analysis showed convergent results: 24 valid items and three factors that 
      include Ethics, Skill, and Person were identified. CONCLUSION: The initial
      knowledge of medical professionalism among first-semester students involves
      approximately 24 important attributes within three major dimensions of Ethics,
      Skill, and Person, with an overwhelming emphasis on Ethics. It is neither
      sophisticated nor comprehensive, compared with specialists' professional
      knowledge.
FAU - Jiang, Suo
AU  - Jiang S
AD  - Wenzhou Medical College, China.
FAU - Yan, Zheng
AU  - Yan Z
FAU - Xie, Xiaodan
AU  - Xie X
FAU - Tang, Wenjie
AU  - Tang W
FAU - Lu, Fan
AU  - Lu F
FAU - He, Jincai
AU  - He J
LA  - eng
PT  - Journal Article
PL  - England
TA  - Med Teach
JT  - Medical teacher
JID - 7909593
SB  - IM
MH  - China
MH  - Data Collection/instrumentation
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Physicians/*standards
MH  - *Professional Competence
MH  - *Students, Medical
EDAT- 2010/11/26 06:00
MHDA- 2011/04/09 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/04/09 06:00 [medline]
AID - 10.3109/0142159X.2010.497827 [doi]
PST - ppublish
SO  - Med Teach. 2010;32(12):961-70. doi: 10.3109/0142159X.2010.497827.


PMID- 21090940
OWN - NLM
STAT- MEDLINE
DCOM- 20110408
LR  - 20101124
IS  - 1466-187X (Electronic)
IS  - 0142-159X (Linking)
VI  - 32
IP  - 12
DP  - 2010
TI  - Students' reflections in a portfolio pilot: highlighting professional issues.
PG  - e532-40
LID - 10.3109/0142159X.2010.509420 [doi]
AB  - BACKGROUND: Portfolios are highlighted as potential assessment tools for
      professional competence. Although students' self-reflections are considered to be
      central in the portfolio, the content of reflections in practice-based portfolios
      is seldom analysed. AIM: To investigate whether students' reflections include
      sufficient dimensions of professional competence, notwithstanding a standardized 
      portfolio format, and to evaluate students' satisfaction with the portfolio.
      METHODS: Thirty-five voluntary final-year medical students piloted a standardized
      portfolio in a general practice (GP) attachment at Lund University, Sweden.
      Students' portfolio reflections were based upon documentary evidence from
      practice, and aimed to demonstrate students' learning. The reflections were
      qualitatively analysed, using a framework approach. Students' evaluations of the 
      portfolio were subjected to quantitative and qualitative analysis. RESULTS: Among
      professional issues, an integration of cognitive, affective and practical
      dimensions in clinical practice was provided by students' reflections. The
      findings suggested an emphasis on affective issues, particularly on
      self-awareness of feelings, attitudes and concerns. In addition, ethical
      problems, clinical reasoning strategies and future communication skills training 
      were subjects of several reflective commentaries. Students' reflections on their 
      consultation skills demonstrated their endeavour to achieve structure in the
      medical interview by negotiation of an agenda for the consultation, keeping the
      interview on track, and using internal summarizing. The importance of active
      listening and exploration of patient's perspective was also emphasized. In
      students' case summaries, illustrating characteristic attributes of GP, the
      dominating theme was 'patient-centred care', including the patient-doctor
      relationship, holistic modelling and longitudinal continuity. Students were
      satisfied with the portfolio, but improved instructions were needed. CONCLUSIONS:
      A standardized portfolio in a defined course with a limited timeframe provided
      ample opportunities for reflections on professional issues. Support by mentors
      and a final examiner interview contributed to the success of the portfolio with
      students. The interview also allowed students to deepen their reflections and to 
      receive feedback.
FAU - Haffling, Ann-Christin
AU  - Haffling AC
AD  - Clinical Research Centre, Malmo University Hospital, Sweden.
      ann-christin.haffling@med.lu.se
FAU - Beckman, Anders
AU  - Beckman A
FAU - Pahlmblad, Annika
AU  - Pahlmblad A
FAU - Edgren, Gudrun
AU  - Edgren G
LA  - eng
PT  - Journal Article
PL  - England
TA  - Med Teach
JT  - Medical teacher
JID - 7909593
SB  - IM
MH  - Education, Medical, Undergraduate
MH  - Female
MH  - General Practice/education
MH  - Humans
MH  - Male
MH  - Pilot Projects
MH  - *Professional Competence
MH  - Program Evaluation
MH  - Students, Medical/*psychology
MH  - Sweden
EDAT- 2010/11/26 06:00
MHDA- 2011/04/09 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/04/09 06:00 [medline]
AID - 10.3109/0142159X.2010.509420 [doi]
PST - ppublish
SO  - Med Teach. 2010;32(12):e532-40. doi: 10.3109/0142159X.2010.509420.


PMID- 21090847
OWN - NLM
STAT- MEDLINE
DCOM- 20110817
LR  - 20101124
IS  - 1132-1989 (Print)
IS  - 1132-1989 (Linking)
VI  - 21
IP  - 73
DP  - 2010 Sep-Dec
TI  - [Justice challenges of pharmaceutical industry global research].
PG  - 375-90
AB  - International research projects sponsored by the pharmaceutical industry are a
      recent modality of biomedical research, which is driven by interests that are not
      only scientific, but also commercial. This combination of interests is one of the
      natural consequences of globalization, which has brought unquestionable benefits 
      for the world, but has also created a wider gap between the wealthy and the poor.
      Given that globalization has been led by the the world's leading economies, the
      level of injustice in the world has increased, often to the favor of the already 
      wealthy. Globalization has a well-established dynamics, whose main characteristic
      is domain over the following: technological innovation, the organization of the
      production of goods and services, human needs, and consumption. International
      biomedical research fits well in this dynamics, and the result is often a poor
      distribution of benefits, added to a loss of scientific integrity for the sake of
      commercial interests. This phenomenon raises many ethical questions and it
      demands a reflection from different bioethical points of view, particularly an
      economic ethics and a global justice.
FAU - Paez Moreno, Ricardo
AU  - Paez Moreno R
AD  - Universidad Nacional Autonoma de Mexico, Programa de Maestria y Doctorado en
      Bioetica, Apdo. Postal 6, 76900, Corregidora Queretaro, Mexico.
      ricardomsps@yahoo.com
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Retos a la justicia en la investigacion global de la industria farmaceutica.
PL  - Spain
TA  - Cuad Bioet
JT  - Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y
      Etica Medica
JID - 101312976
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Commerce/ethics
MH  - Drug Industry/*ethics
MH  - Humans
MH  - Internationality
MH  - Multicenter Studies as Topic
MH  - *Social Justice
EDAT- 2010/11/26 06:00
MHDA- 2011/08/19 06:00
CRDT- 2010/11/25 06:00
PHST- 2009/08/25 00:00 [received]
PHST- 2010/09/14 00:00 [accepted]
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/08/19 06:00 [medline]
PST - ppublish
SO  - Cuad Bioet. 2010 Sep-Dec;21(73):375-90.


PMID- 21090844
OWN - NLM
STAT- MEDLINE
DCOM- 20110817
LR  - 20140730
IS  - 1132-1989 (Print)
IS  - 1132-1989 (Linking)
VI  - 21
IP  - 73
DP  - 2010 Sep-Dec
TI  - [Bioethical analysis in pregnancy's Jehova Witnesess and transfusion refusal].
PG  - 327-39
AB  - UNLABELLED: In Mexico, Jehovah's witnesses present letters to their doctors that 
      exonerate them in case of a patient's decease if hemotherapy was not applied.
      Although those letters have no legal validity in Mexico, this topic is a hot spot
      for debate, especially when dealing with competent adults. Bibliography exists,
      both pro and against this posture, but, an empty gap is observed in the case of
      pregnancy. With pregnancy, we doctors, find ourselves, both in the medical and
      ethical area, upon two patients: mother and son. Doctors have the same
      therapeutical responsibilities upon them. What alternatives would be presented in
      our country if the Jehovah's Witness's transfusional negative was accepted, and
      we had a pregnant patient in the need of one? Juridically, the acceptance of
      adult Jehovah's Witness's thesis is included under the acceptance of moral
      objection, however: 1) Moral objection is not a general right, but exceptional,
      with a justified reason. 2) It can not produce any possible harm to third
      parties. The conflict of interest mother/fetus in hemotherapeutical urgencies can
      be tackled under three possibilities: a) Total respect to mother's autonomy.
      RESULT: high death possibility for both mother and fetus. b) Not to respect
      mother's autonomy. RESULT: high life possibilities for mother and fetus. c)
      Respect mother's negative to be transfunded and to operate maneuvers for fetal
      rescue. RESULT: high death possibilities for mother and relative life
      possibilities for fetal life. The physician, when dealing with a pregnant woman, 
      has a responsibility with two patients. As a first intention, the doctor should
      always offer a proper handle of the case, according to the pregnant patient's
      beliefs as much as possible, nevertheless he must never forget his compromise to 
      the embryo's/fetus's life.
FAU - Casas-Martinez, Maria de la Luz
AU  - Casas-Martinez Mde L
AD  - Departamento de Bioetica, Escuela de Medicina, Universidad Panamericana, Mexico. 
      mcasas@mx.up.mx
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Analisis bioetico del embarazo en testigos de jehova y el rechazo transfusional.
PL  - Spain
TA  - Cuad Bioet
JT  - Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y
      Etica Medica
JID - 101312976
SB  - IM
MH  - Adult
MH  - *Bioethical Issues
MH  - Blood Transfusion/*ethics
MH  - Female
MH  - Fetus
MH  - Humans
MH  - *Jehovah's Witnesses
MH  - Pregnancy
MH  - Treatment Refusal/*ethics
EDAT- 2010/11/26 06:00
MHDA- 2011/08/19 06:00
CRDT- 2010/11/25 06:00
PHST- 2009/06/06 00:00 [received]
PHST- 2009/12/31 00:00 [accepted]
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/08/19 06:00 [medline]
PST - ppublish
SO  - Cuad Bioet. 2010 Sep-Dec;21(73):327-39.


PMID- 21090187
OWN - NLM
STAT- MEDLINE
DCOM- 20101215
LR  - 20181201
IS  - 1447-4514 (Print)
IS  - 1447-4514 (Linking)
VI  - 34
IP  - 3
DP  - 2010 Sep
TI  - A new national Chlamydia Sentinel Surveillance System in Australia: evaluation of
      the first stage of implementation.
PG  - 319-28
AB  - The Australian Collaboration for Chlamydia Enhanced Sentinel Surveillance
      (ACCESS) was established with funding from the Department of Health and Ageing to
      trial the monitoring of the uptake and outcome of chlamydia testing in Australia.
      ACCESS involved 6 separate networks; 5 clinical networks involving sexual health 
      services, family planning clinics, general practices, antenatal clinics,
      Aboriginal community controlled health services, and 1 laboratory network. The
      program ran from May 2007 to September 2010. An evaluation of ACCESS was
      undertaken in early 2010, 2 years after the program was funded. At the time of
      the evaluation, 76 of the 91 participating sites were contributing data. The
      jurisdictional distribution of the 76 sites generally matched the jurisdictional 
      distribution of the Australian population. In 2008, the chlamydia testing rates
      in persons aged 16-29 years attending the 26 general practices was 4.2% in males 
      and 7.0% in females. At the 25 sexual health services, the chlamydia testing
      rates in heterosexuals aged less than 25 years in 2008 was 77% in males and 74%
      in females. Between 2004 and 2008, the chlamydia positivity rate increased
      significantly in heterosexual females aged less than 25 years attending the
      sexual health services, from 11.5% to 14.1% (P < 0.01). Data completeness was
      above 85% for all core variables except Aboriginal and/or Torres Strait Islander 
      status and country of birth, which ranged from 68%-100%, and 74%-100%,
      respectively, per network. There were delays in establishment of the system due
      to recruitment of 91 sites, multiple ethics applications and establishment of
      automated extraction programs in 10 different database systems, to transform
      clinic records into a common, pre-defined surveillance format. ACCESS has
      considerable potential as a mechanism toward supporting a better understanding of
      long-term trends in chlamydia notifications and to support policy and program
      delivery.
FAU - Guy, Rebecca J
AU  - Guy RJ
AD  - National Centre in HIV Epidemiology and Clinical Research, University of New
      South Wales, Sydney, New South Wales. Rguy@nchecr.unsw.edu.au
FAU - Kong, Fabian
AU  - Kong F
FAU - Goller, Jane
AU  - Goller J
FAU - Franklin, Neil
AU  - Franklin N
FAU - Bergeri, Isabel
AU  - Bergeri I
FAU - Dimech, Wayne
AU  - Dimech W
FAU - Reilly, Nicole
AU  - Reilly N
FAU - Sullivan, Elizabeth
AU  - Sullivan E
FAU - Ward, James
AU  - Ward J
FAU - Kaldor, John M
AU  - Kaldor JM
FAU - Hellard, Margaret
AU  - Hellard M
FAU - Donovan, Basil
AU  - Donovan B
CN  - ACCESS Collaboration
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Commun Dis Intell Q Rep
JT  - Communicable diseases intelligence quarterly report
JID - 101601804
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Australia/epidemiology
MH  - Chlamydia Infections/*diagnosis/*epidemiology
MH  - Female
MH  - Guideline Adherence/*statistics & numerical data
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Mass Screening/*statistics & numerical data
MH  - *Program Evaluation
MH  - *Sentinel Surveillance
MH  - Young Adult
IR  - Hocking J
FIR - Hocking, Jane
IR  - Boyle D
FIR - Boyle, Douglas
IR  - Merritt T
FIR - Merritt, Tony
IR  - Britt H
FIR - Britt, Helena
IR  - Lau P
FIR - Lau, Phyllis
IR  - Pirotta M
FIR - Pirotta, Marie
IR  - Heal C
FIR - Heal, Clare
IR  - Brett T
FIR - Brett, Tom
IR  - Fairley C
FIR - Fairley, Christopher
IR  - Chen M
FIR - Chen, Marcus
IR  - O'Connor C
FIR - O'Connor, Catherine
IR  - Marshall L
FIR - Marshall, Lewis
IR  - Dickson B
FIR - Dickson, Bridget
IR  - Grulich A
FIR - Grulich, Andrew
IR  - Harvey C
FIR - Harvey, Caroline
IR  - O'Neil L
FIR - O'Neil, Lee
IR  - Jordan L
FIR - Jordan, Lynne
IR  - Stephens A
FIR - Stephens, Anne
IR  - Read C
FIR - Read, Christine
IR  - Wright D
FIR - Wright, Deborah
IR  - Bekmann M
FIR - Bekmann, Michael
IR  - MacPhail J
FIR - MacPhail, Julie
IR  - Currie M
FIR - Currie, Mariam
IR  - Robinson Z
FIR - Robinson, Zena
IR  - Miller T
FIR - Miller, Trent
IR  - Halliday M
FIR - Halliday, Megan
IR  - Goldwater P
FIR - Goldwater, Paul
IR  - Adams M
FIR - Adams, Mick
IR  - Saunders M
FIR - Saunders, Mark
IR  - Hunt J
FIR - Hunt, Jenny
IR  - Waples-Crowe P
FIR - Waples-Crowe, Peter
IR  - Eades F
FIR - Eades, Francine
IR  - Scrimgeour D
FIR - Scrimgeour, David
IR  - Williams S
FIR - Williams, Sid
IR  - Mundy C
FIR - Mundy, Cheryl
IR  - Herceg A
FIR - Herceg, Ana
IR  - Moore L
FIR - Moore, Liz
EDAT- 2010/11/26 06:00
MHDA- 2010/12/16 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2010/12/16 06:00 [medline]
PST - ppublish
SO  - Commun Dis Intell Q Rep. 2010 Sep;34(3):319-28.


PMID- 21090143
OWN - HSR
STAT- MEDLINE
DCOM- 20101130
LR  - 20101122
IS  - 0097-6326 (Print)
IS  - 0097-6326 (Linking)
VI  - 75
IP  - 220
DP  - 2010 Nov 16
TI  - Responding to disruptive patients. Final rule.
PG  - 69881-3
AB  - This final rule amends the Department of Veterans Affairs (VA) regulation that
      authorizes appropriate action when a patient engages in disruptive behavior at a 
      VA medical facility. This amendment updates VA's current regulation to reflect
      modern medical care and ethical practices. The final rule authorizes VA to modify
      the time, place, and/or manner in which VA provides treatment to a patient, in
      order to ensure the safety of others at VA medical facilities, and to prevent any
      interference with the provision of medical care.
CN  - Department of Veterans Affairs
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Fed Regist
JT  - Federal register
JID - 7808722
MH  - Attention Deficit and Disruptive Behavior Disorders/*prevention & control
MH  - Conduct Disorder/*prevention & control
MH  - Ethics, Medical
MH  - *Hospitals, Veterans
MH  - Humans
MH  - Mental Disorders/*prevention & control
MH  - Organizational Policy
MH  - Patient Rights/*legislation & jurisprudence
MH  - Patients/legislation & jurisprudence
MH  - Risk Management/ethics
MH  - Safety
MH  - United States
MH  - Veterans/legislation & jurisprudence
EDAT- 2010/11/26 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - Fed Regist. 2010 Nov 16;75(220):69881-3.


PMID- 21089997
OWN - NLM
STAT- MEDLINE
DCOM- 20101208
LR  - 20101122
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 21
IP  - 3
DP  - 2010 Fall
TI  - The ambiguous effects of tort law on bioethics: the case of doctor-patient
      communication.
PG  - 264-71
AB  - Tort law is an important tool in enforcing a minimal level of good behavior. But 
      what is appropriate for law is not necessarily appropriate for ethics or for
      norms of professional practice.
FAU - Davis, Dena S
AU  - Davis DS
AD  - Cleveland-Marshall College of Law, Cleveland State University, USA.
      dena.davis@law.csuohio.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
MH  - Bioethics
MH  - *Communication
MH  - *Ethics, Clinical
MH  - Ethics, Medical
MH  - Ethics, Nursing
MH  - Humans
MH  - *Liability, Legal
MH  - *Physician-Patient Relations/ethics
EDAT- 2010/11/26 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2010 Fall;21(3):264-71.


PMID- 21089993
OWN - NLM
STAT- MEDLINE
DCOM- 20101208
LR  - 20220103
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 21
IP  - 3
DP  - 2010 Fall
TI  - Dying but not killing: donation after cardiac death donors and the recovery of
      vital organs.
PG  - 229-31
AB  - Michael Potts, Paul A. Byrne, and David W. Evans are critical of donation after
      cardiac death (DCD). Contrary to the authors' assertion that the removal of vital
      organs is the proximate cause of death, the eventual fulfillment of the
      neurological criteria of death is solely dependant on the rate of brain cell
      death in the absence of circulation. Consistent with the "dead donor rule," DCD
      is not the cause of death.There are also procedural mechanisms to address the
      potential conflicts of interest that concern the authors. Rather than being
      prohibited, DCD may be an ethically justifiable exception to the rule that organ 
      donors must be dead prior to organ recovery.
FAU - Antommaria, Armand H Matheny
AU  - Antommaria AH
AD  - Department of Pediatrics, University of Utah School of Medicine in Salt Lake
      City, USA. armand.antommaria@hsc.utah.edu
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
CON - J Clin Ethics. 2010 Fall;21(3):224-8. PMID: 21089992
MH  - *Death
MH  - Ethics, Clinical
MH  - Ethics, Medical
MH  - *Homicide/ethics/legislation & jurisprudence
MH  - Humans
MH  - Organ Transplantation/ethics/legislation & jurisprudence
MH  - Physicians/*ethics
MH  - Tissue and Organ Harvesting/*ethics/*legislation & jurisprudence
MH  - Tissue and Organ Procurement/*ethics/*legislation & jurisprudence
EDAT- 2010/11/26 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2010 Fall;21(3):229-31.


PMID- 21089992
OWN - NLM
STAT- MEDLINE
DCOM- 20101208
LR  - 20101122
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 21
IP  - 3
DP  - 2010 Fall
TI  - Infant heart transplantation after cardiac death: ethical and legal problems.
PG  - 224-8
AB  - The donation of organs after cardiac death in infants is not morally justified
      and should not be continued.
FAU - Potts, Michael
AU  - Potts M
AD  - Methodist University, Fayetteville, North Carolina, USA. gratiaetnatura@yahoo.com
FAU - Byrne, Paul A
AU  - Byrne PA
FAU - Evans, David W
AU  - Evans DW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
CIN - J Clin Ethics. 2010 Fall;21(3):229-31. PMID: 21089993
MH  - *Beneficence
MH  - Death
MH  - Ethics, Clinical
MH  - Ethics, Medical
MH  - *Heart Arrest
MH  - Heart Transplantation/*ethics/*legislation & jurisprudence
MH  - *Homicide/ethics/legislation & jurisprudence
MH  - Humans
MH  - Infant
MH  - Organ Transplantation/ethics/legislation & jurisprudence
MH  - Physicians/*ethics
MH  - Tissue and Organ Harvesting/*ethics/*legislation & jurisprudence
EDAT- 2010/11/26 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2010 Fall;21(3):224-8.


PMID- 21089990
OWN - NLM
STAT- MEDLINE
DCOM- 20101208
LR  - 20101122
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 21
IP  - 3
DP  - 2010 Fall
TI  - Characterizing the level of risk in pediatric research: an ethical examination of
      the federal regulations.
PG  - 212-20
AB  - Federal regulations require that the level of risk posed by pediatric research be
      classified as "minimal," "greater than minimal," or "a minor increase over
      minimal" Interpretation of the meaning of the levels has produced a significant
      literature exploring the ethical basis for making these determinations. This
      article examines the ethical basis of a variety of approaches proposed in the
      literature for classifying pediatric research risk. These approaches strive to
      take into account how society decides which risks are routinely accepted for
      children outside of research. It is concluded that ways of classifying risk
      should compare research risks to normal risks for children without special
      disability and take into account the concerns of the research subject's
      community.
FAU - Dyson, Maynard
AU  - Dyson M
AD  - Cook Children's Health Care System, Fort Worth, Texas, USA.
      maynard.dyson@cookchildrens.org
FAU - Parsi, Kayhan
AU  - Parsi K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Clinical Trials as Topic/*ethics/*legislation & jurisprudence
MH  - *Federal Government
MH  - *Government Regulation
MH  - Human Experimentation/*ethics/*legislation & jurisprudence
MH  - Humans
MH  - Infant
MH  - Minors/*legislation & jurisprudence
MH  - *Pediatrics/ethics/legislation & jurisprudence
MH  - *Risk Assessment
MH  - United States
EDAT- 2010/11/26 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2010 Fall;21(3):212-20.


PMID- 21089989
OWN - NLM
STAT- MEDLINE
DCOM- 20101208
LR  - 20181201
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 21
IP  - 3
DP  - 2010 Fall
TI  - "Broken covenant": healthcare aides' "experience of the ethical" in caring for
      dying seniors in a personal care home.
PG  - 201-11
AB  - Canada's population is aging, and seniors constitute the fastest growing
      demographic in the nation. The chronic health conditions, limited social support,
      functional decline, and cognitive impairment experienced by seniors may
      necessitate admission to a personal care home (PCH) setting up until the time of 
      their death. The ethical problems that arise in the care of dying patients are
      numerous and complicated. The care of dying seniors in PCHs, however, is largely 
      provided by frontline workers such as healthcare aides (HCAs), who usually have
      little training in palliative care or ethics. Research examining the
      identification and resolution of ethical problems in care of the dying has been
      conducted from the perspectives of nurses and physicians in various clinical
      settings, but the voice of HCAs in PCHs is virtually absent from clinical ethics.
      Given that the inability to satisfactorily resolve ethical issues in clinical
      practice is associated with feelings of guilt, powerlessness, avoiding contact
      with patients, failing to provide good physical care, and increased staff
      turnover, an empirical examination of HCAs' experiences of ethically challenging 
      situations is warranted. We conducted a phenomenological study to access the
      lived experience of HCAs (N = 12) working in proprietary and nonproprietary care 
      homes as they encountered situations they deemed ethically challenging in
      providing end-of-life care to dying seniors. The findings reported here
      explicate: (1) the types of situations that are ethically problematic for HCAs;
      (2) the meanings they assign to these situations, and (3) the impact such
      situations have on the provision of end-of-life care.
FAU - McClement, Susan
AU  - McClement S
AD  - Faculty of Nursing, University of Manitoba, Winnipeg.
      susan.mcclement@cancercare.mb.ca
FAU - Lobchuk, Michelle
AU  - Lobchuk M
FAU - Chochinov, Harvey Max
AU  - Chochinov HM
FAU - Dean, Ruth
AU  - Dean R
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
CIN - J Clin Ethics. 2010 Fall;21(3):179-88. PMID: 21089987
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Attitude of Health Personnel
MH  - Attitude to Death
MH  - Canada
MH  - Female
MH  - Humans
MH  - Long-Term Care/*ethics
MH  - Male
MH  - Middle Aged
MH  - *Nursing Assistants/ethics/standards
MH  - *Nursing Homes/standards
MH  - Terminal Care/*ethics/*standards
MH  - Workforce
EDAT- 2010/11/26 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2010 Fall;21(3):201-11.


PMID- 21089988
OWN - NLM
STAT- MEDLINE
DCOM- 20101208
LR  - 20101122
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 21
IP  - 3
DP  - 2010 Fall
TI  - The rational choice model in family decision making at the end of life.
PG  - 189-200
AB  - BACKGROUND: Most end-of-life decisions are made by family members. Current
      ethical guidelines for family decision making are based on a hierarchical model
      that emphasizes the patient's wishes over his or her best interests. Evidence
      suggests that the model poorly reflects the strategies and priorities of many
      families. METHODS: Researchers observed and recorded 26 decision-making meetings 
      between hospital staff and family members. Semi-structured follow-up interviews
      were conducted. Transcriptions were analyzed using qualitative techniques.
      RESULTS: For both staff and families, consideration of a patient's best interests
      generally took priority over the patient's wishes. Staff generally introduced
      discussion of the patient's wishes for rhetorical purposes, such as persuasion.
      Competing moral frameworks, which de-emphasized the salience of patients'
      autonomy and "right to choose," played a role in family decision making.
      CONCLUSIONS: The priority given to the patients' wishes in the hierarchical model
      does not reflect the priorities of staff and families in making decisions about
      end-of-life care.
FAU - Karasz, Alison
AU  - Karasz A
AD  - Department of Family Medicine, Albert Einstein College of Medicine, Bronx, New
      York, USA. akkarasz@montefiore.org
FAU - Sacajiu, Galit
AU  - Sacajiu G
FAU - Kogan, Misha
AU  - Kogan M
FAU - Watkins, Liza
AU  - Watkins L
LA  - eng
GR  - R03 AG023236-01/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
MH  - *Advance Directives
MH  - Aged
MH  - Choice Behavior/ethics
MH  - Decision Making/*ethics
MH  - *Family
MH  - Female
MH  - Humans
MH  - Male
MH  - Mental Competency
MH  - *Personal Autonomy
MH  - Terminal Care/*ethics
EDAT- 2010/11/26 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2010 Fall;21(3):189-200.


PMID- 21089987
OWN - NLM
STAT- MEDLINE
DCOM- 20101208
LR  - 20181201
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 21
IP  - 3
DP  - 2010 Fall
TI  - All careproviders need more opportunities to share their ethical concerns with
      others.
PG  - 179-88
AB  - Attention to the ethical concerns of healthcare aides can provide important
      information about patients' needs to careproviders, improve the ethical
      environment of an institution, and benefit aides who suffer from bearing ethical 
      concerns alone. All persons benefit from sharing their ethical concerns with
      others. Among other benefits, ethics consultation offers careproviders,
      caregivers, healthcare aides, patients, and patients' loved ones an opportunity
      to have their concerns heard. John Fletcher tried to follow every ethics
      consultation with a debriefing for all participants, including patients and
      family members, to increase the possibility for continued healing after the
      conclusion of the consultation, and there are good reasons to follow this
      practice.
FAU - Howe, Edmund G
AU  - Howe EG
AD  - Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
CON - J Clin Ethics. 2010 Fall;21(3):201-11. PMID: 21089989
MH  - *Alzheimer Disease/diagnosis/drug therapy
MH  - Caregivers/psychology
MH  - Cooperative Behavior
MH  - *Dissent and Disputes
MH  - *Ethics Consultation/organization & administration/standards
MH  - Humans
MH  - *Nursing Assistants/psychology/standards
MH  - *Nursing Homes
MH  - Pain/drug therapy
MH  - *Personal Autonomy
MH  - Severity of Illness Index
MH  - Workforce
EDAT- 2010/11/26 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2010 Fall;21(3):179-88.


PMID- 21089732
OWN - NLM
STAT- MEDLINE
DCOM- 20101230
LR  - 20151119
IS  - 0026-4946 (Print)
IS  - 0026-4946 (Linking)
VI  - 62
IP  - 3 Suppl 1
DP  - 2010 Jun
TI  - Decision making in neonatologia.
PG  - 121-3
AB  - The field of neonatology presents a fascinating context in which hugely important
      decisions have to be made on the basis of physicians' assessments of the long
      term consequences of various possible choices. In many cases such assessments
      cannot be derived from a consensual professional opinion; the situation is
      characterized by a high level of uncertainty. A sample of neonatologists in
      different countries received a questionnaire including vignette cases for which
      no clear consensus exists regarding the (probabilistic) prognosis. They were
      asked to (I) assess the probability of various outcomes (death, severe
      impairment) and (II) choose a treatment to be offered to the parents. Information
      on the physicians' professional and socio-demographic characteristics and their
      ethical "values" was also collected. The goal of this international survey is to 
      understand the prognosis and to analyze decision making by professionals in the
      context of life and death in medicine. The availability of an identical
      technology in different social and institutional contexts should help identifying
      the convergences and differences under consideration. Seventy percent of those
      invited responded to the questionnaire (International 60-80%). Italian
      neonatologists seem to be quite pessimistic about the prognosis of infants at
      high risk of death or long term disabilities, they show a pro-life attitude, but 
      in a certain proportion are willing to change their minds if requested by
      parents. Furthermore personal opinions predominate in the decision-making process
      and the contribution of team meeting and/or ethic consultation seem not
      significantly modify the decisions.
FAU - Paterlini, G
AU  - Paterlini G
FAU - Tagliabue, P
AU  - Tagliabue P
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - Minerva Pediatr
JT  - Minerva pediatrica
JID - 0400740
SB  - IM
MH  - Attitude of Health Personnel
MH  - Attitude to Death
MH  - *Decision Making/ethics
MH  - Dissent and Disputes
MH  - Europe
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Newborn, Diseases/psychology/therapy
MH  - Japan
MH  - Male
MH  - Medical Futility
MH  - Neonatology/ethics/*methods
MH  - Parents/psychology
MH  - Physicians/ethics/*psychology
MH  - Professional-Family Relations
MH  - Prognosis
MH  - Surveys and Questionnaires
MH  - United States
MH  - Value of Life
EDAT- 2010/11/26 06:00
MHDA- 2010/12/31 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2010/12/31 06:00 [medline]
PST - ppublish
SO  - Minerva Pediatr. 2010 Jun;62(3 Suppl 1):121-3.


PMID- 21089690
OWN - NLM
STAT- MEDLINE
DCOM- 20120216
LR  - 20101119
IS  - 1001-5515 (Print)
IS  - 1001-5515 (Linking)
VI  - 27
IP  - 5
DP  - 2010 Oct
TI  - [Histocompatibility and imprinting status of parthenogenetic embryonic stem
      cells].
PG  - 1158-61
AB  - The parthenogenetic embryonic stem cells (pESCs) derived from parthenogenetic
      embryos have the totipotency and proliferation capacity similar to those of the
      fertilized embryonic stem cells (fESCs). Therefore, the establishment of pESCs
      line avoids destroy of embryo and kence may make pESCs less concerns with
      political and ethical issues. These cells are characterized by their
      histocompatibility with the oocyte donor and therefore is more suitable for cell 
      and tissue replacement therapy. In addition, because of the typical imprinting
      status, pESCs also provide a valuable in vitro model system for studying the
      molecular mechanisms in genomic imprinting.
FAU - Xue, Yuan
AU  - Xue Y
AD  - Department of Histology and Embryology, Harbin Medical University, Harbin 150081,
      China.
FAU - Shan, Zhiyan
AU  - Shan Z
FAU - Zheng, Zhong
AU  - Zheng Z
FAU - Lei, Lei
AU  - Lei L
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - China
TA  - Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
JT  - Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering =
      Shengwu yixue gongchengxue zazhi
JID - 9426398
SB  - IM
MH  - Animals
MH  - Embryonic Stem Cells/*cytology
MH  - Female
MH  - Gene Expression Profiling/methods
MH  - Gene Expression Regulation, Developmental/genetics/physiology
MH  - *Genomic Imprinting
MH  - Histocompatibility
MH  - Parthenogenesis/genetics/*physiology
MH  - Pluripotent Stem Cells/cytology
EDAT- 2010/11/26 06:00
MHDA- 2012/02/18 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2012/02/18 06:00 [medline]
PST - ppublish
SO  - Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2010 Oct;27(5):1158-61.


PMID- 21089649
OWN - NLM
STAT- MEDLINE
DCOM- 20120216
LR  - 20101119
IS  - 1001-5515 (Print)
IS  - 1001-5515 (Linking)
VI  - 27
IP  - 5
DP  - 2010 Oct
TI  - [Brain functional connectivity in depression during emotion processing].
PG  - 961-7
AB  - Cognitive and emotional dysfunction in depressed patients has been broadly
      researched. However, the physiological mechanism of the emotional impairment is
      still obscure. In this study, according to the ethical principles and the
      procedures of informed consent, we enrolled 16 depression patients and 16 normal 
      subjects in a "learning-judgment" cognitive task. Emotional faces were chosen and
      used as the visual stimuli, while the subjects' scalp electroencephalographs
      (EEG) were recorded. We calculated the coherences of the event-related EEG
      signals between different functional brain regions and used the repeated measure 
      analysis of variance (ANOVA) to analyze the coherences. The results revealed, (1)
      The depressed patients had a significantly lower inter-hemisphere coherence than 
      did the normal controls at frontal sites across all EEG basic rhythms; (2) The
      inter-hemispheric coherence of EEG beta activity was significantly correlated
      with the emotional processing during 1-200 ms after stimulus onset, and the
      synchronicity with the negative emotion stimulus was higher than that with
      neutral and positive stimuli; (3) The main effect of race was found at delta and 
      theta bands at about 401-600 ms after stimulus onset. Moreover, the connectivity 
      of inter-hemisphere for own-race stimulus was stronger than that for other-race
      stimulus.
FAU - Wei, Ling
AU  - Wei L
AD  - School of Communication and Information Engineering, Shanghai University Shanghai
      200072, China.
FAU - Li, Yingjie
AU  - Li Y
FAU - Tang, Yingying
AU  - Tang Y
FAU - Wang, Jijun
AU  - Wang J
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
JT  - Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering =
      Shengwu yixue gongchengxue zazhi
JID - 9426398
SB  - IM
MH  - Brain/*physiopathology
MH  - Cognition/physiology
MH  - Depression/physiopathology/*psychology
MH  - Electroencephalography/*methods
MH  - Emotions/*physiology
MH  - Evoked Potentials/physiology
MH  - Humans
EDAT- 2010/11/26 06:00
MHDA- 2012/02/18 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2012/02/18 06:00 [medline]
PST - ppublish
SO  - Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2010 Oct;27(5):961-7.


PMID- 21089467
OWN - NLM
STAT- MEDLINE
DCOM- 20101220
LR  - 20101119
IS  - 0023-2149 (Print)
IS  - 0023-2149 (Linking)
VI  - 88
IP  - 5
DP  - 2010
TI  - [Why ethical committees in hospitals?].
PG  - 72-4
FAU - Shamov, I A
AU  - Shamov IA
LA  - rus
PT  - Journal Article
PL  - Russia (Federation)
TA  - Klin Med (Mosk)
JT  - Klinicheskaia meditsina
JID - 2985204R
SB  - IM
MH  - *Ethics Committees, Clinical
MH  - Hospitals/*ethics
MH  - Humans
EDAT- 2010/11/26 06:00
MHDA- 2010/12/21 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2010/12/21 06:00 [medline]
PST - ppublish
SO  - Klin Med (Mosk). 2010;88(5):72-4.


PMID- 21089424
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20101119
IS  - 0035-3639 (Print)
IS  - 0035-3639 (Linking)
VI  - 31
IP  - 4
DP  - 2010 Sep
TI  - [Family violence and generations].
PG  - 432-8
AB  - Starting with a description of the place and function of violence inside
      families, the author raises than the topics of the professional's ethic and
      responsibility when working with family violence. It is not always easy for
      professionals to evaluate responsibilities particularly when they try to take
      into account as many contextual factors as possible. They could worry to become
      too Manichean and to see themselves as following only a linear causality.
FAU - Goldbeter-Merinfeld, E
AU  - Goldbeter-Merinfeld E
AD  - Institut d'Etudes de la Famille et des Systemes Humains, Bruxelles et Faculte de 
      Psychologie, ULB. edith.goldbeter@ulb.ac.be
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Violences intrafamiliales et generations.
PL  - Belgium
TA  - Rev Med Brux
JT  - Revue medicale de Bruxelles
JID - 8003474
SB  - IM
MH  - *Domestic Violence/legislation & jurisprudence
MH  - Humans
MH  - Intergenerational Relations
EDAT- 2010/11/26 06:00
MHDA- 2011/01/07 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
PST - ppublish
SO  - Rev Med Brux. 2010 Sep;31(4):432-8.


PMID- 21089423
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20101119
IS  - 0035-3639 (Print)
IS  - 0035-3639 (Linking)
VI  - 31
IP  - 4
DP  - 2010 Sep
TI  - [Interfamilial violence, medicolegal and ethical aspects].
PG  - 426-31
AB  - Domestic or interfamilial violence--which is certainly not confined to
      disadvantaged social or cultural classes--is a process in which one partner
      carries against his spouse within the framework of private and privileged
      relationship (marriage, cohabitation, etc.), aggressive, violent and destructive 
      behavior. All sectors of society are affected, whether urban or rural, and
      regardless of education or ethnic origin or religion. Such violence particularly 
      affects women, but there are also violence perpetrated against men. This violence
      can take many forms, but we will only consider here the forensic clinical
      aspects, emphasizing the relevant legislation and medical ethics.
FAU - Beauthier, J P
AU  - Beauthier JP
AD  - Unite de Medecine Legale, Laboratoire d'Anatomie, de Biomecanique et
      d'Organogenese, ULB, Departement de Medecine Legale, Palais de Justice de
      Charleroi. jean-pol.beauthier@ulb.ac.be
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Les aspects medico-legaux et deontologiques des violences intraconjugales.
PL  - Belgium
TA  - Rev Med Brux
JT  - Revue medicale de Bruxelles
JID - 8003474
SB  - IM
MH  - Domestic Violence/*ethics/*legislation & jurisprudence
MH  - Female
MH  - Humans
MH  - Male
EDAT- 2010/11/26 06:00
MHDA- 2011/01/07 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
PST - ppublish
SO  - Rev Med Brux. 2010 Sep;31(4):426-31.


PMID- 21089412
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20101119
IS  - 0035-3639 (Print)
IS  - 0035-3639 (Linking)
VI  - 31
IP  - 4
DP  - 2010 Sep
TI  - [End of life of demented patients: ethical aspects].
PG  - 333-41
AB  - Most people in contemporary western society die of the chronic diseases of old
      age. Whilst palliative care is appropriate for elderly patients with chronic,
      non-malignant disease, few of these patients access such care compared with
      cancer patients. That patients dying with dementia have significant health care
      needs, comparable with cancer patients, is now well established. Yet, their
      families typically describe poor advance-care planning and an inadequate level of
      symptom control, with distress associated with pain, pressure sores,
      constipation, restlessness and shortness of breath. A comparison of people dying 
      with advanced dementia or terminal cancer found that those with dementia were
      more likely to experience burdensome interventions and restraints and to have had
      poor advance-care planning. Prognostic models that attempt to estimate survival
      of >6 months in demented patients have generally poor discrimination, reflecting 
      the unpredictable nature of most nonmalignant disease. However, a number of
      generic and disease-specific predictor variables were identified that may help
      clinicians identify older, non-cancer patients with poor prognoses and palliative
      care needs. Simple, well-validated prognostic models that provide clinicians with
      objective measures of palliative status in demented patients are needed.
      Additionally, research that analyses the effect of comprehensive geriatric
      assessment and geriatric palliative care on psychosocial outcomes in demented
      patients and their caregivers is needed. Advances care planning and directives
      making before death allow meeting patient's preferences.
FAU - Pepersack, T
AU  - Pepersack T
AD  - Clinique de Geriatrie, Hopital Erasme, Bruxelles.
      thierry.pepersack@erasme.ulb.ac.be
LA  - fre
PT  - English Abstract
PT  - Historical Article
PT  - Journal Article
TT  - Fin de vie des patients dements: aspects ethiques.
PL  - Belgium
TA  - Rev Med Brux
JT  - Revue medicale de Bruxelles
JID - 8003474
SB  - IM
MH  - Advance Directives
MH  - *Dementia/nursing
MH  - History, 18th Century
MH  - Humans
MH  - Malnutrition
MH  - Palliative Care/*ethics
MH  - Prognosis
EDAT- 2010/11/26 06:00
MHDA- 2011/01/07 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
PST - ppublish
SO  - Rev Med Brux. 2010 Sep;31(4):333-41.


PMID- 21070311
OWN - NLM
STAT- MEDLINE
DCOM- 20110217
LR  - 20101112
IS  - 1471-6712 (Electronic)
IS  - 0283-9318 (Linking)
VI  - 24 Suppl 1
DP  - 2010 Dec
TI  - Narrative hermeneutics: in search of narrative data.
PG  - 32-7
LID - 10.1111/j.1471-6712.2010.00846.x [doi]
AB  - As human beings, we live in a storied world. This worldview requires us to think 
      about how to re-present it in research. My purpose with this article is to
      reflect upon narratives from an ontological and epistemological point of view,
      taking Ricoeur's writings on narrative identity as a starting point. From this
      perspective, narration is an aspect of self-interpretation and
      self-understanding. Furthermore, self-understanding is not only achieved within
      our own narratives, but depends upon the regard, words and actions of others.
      This must be accounted for in our search for narrative data. Researchers would
      benefit from being alert to this and also aware of how narratives are co-authored
      in a dialogue with participants. Reflections on narration from this perspective
      could guide ethical considerations - and also methodological - as they could
      support questions that would create space for the narrative. Furthermore, the
      researcher must be aware that the quality and trustworthiness of narratives to a 
      high degree depend on the researcher and not only on the participant.
CI  - (c) 2010 The Author. Scandinavian Journal of Caring Sciences (c) 2010 Nordic
      College of Caring Science.
FAU - Wiklund-Gustin, Lena
AU  - Wiklund-Gustin L
AD  - School of Health, Care and Social Welfare, Malardalen University, Vasteras,
      Sweden. lena.wiklund@mdh.se
LA  - eng
PT  - Journal Article
PL  - Sweden
TA  - Scand J Caring Sci
JT  - Scandinavian journal of caring sciences
JID - 8804206
MH  - Ethics
MH  - Interpersonal Relations
MH  - *Narration
EDAT- 2010/11/26 06:00
MHDA- 2011/02/18 06:00
CRDT- 2010/11/13 06:00
PHST- 2010/11/13 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/02/18 06:00 [medline]
AID - 10.1111/j.1471-6712.2010.00846.x [doi]
PST - ppublish
SO  - Scand J Caring Sci. 2010 Dec;24 Suppl 1:32-7. doi:
      10.1111/j.1471-6712.2010.00846.x.


PMID- 21089023
OWN - NLM
STAT- MEDLINE
DCOM- 20110302
LR  - 20151119
IS  - 0189-160X (Print)
IS  - 0189-160X (Linking)
VI  - 29
IP  - 5
DP  - 2010 Sep-Oct
TI  - Impact of hypertension on sexual function in women.
PG  - 344-8
AB  - BACKGROUND: the effect of hypertension and its treatment on female sexual
      function is largely unexplored especially in Africa. However in practice, cases
      abound where consequent sexual dysfunction leads to poor or non-adherence with
      catastrophic results. Believing that like in males, hypertension and its
      treatment should affect female sexual function; we set out using a structured
      questionnaire to study the subject as it affects women. OBJECTIVE: to examine the
      relationship between hypertension and female sexual functions of arousal,
      lubrication and orgasm. METHODS: five hundred questionnaires were distributed to 
      consenting Nigerian women after ethical clearance was obtained. Information
      sought included demographics, menstrual history, medical treatment and sexual
      function. RESULTS: a total of 454 returned questionnaires were analysable. Out of
      this, 109(24%) admitted to being hypertensive, 89 of whom were on treatment.
      Hypertension was related to difficulty with sustaining sexual excitement
      (p=0.03), decreased sexual thoughts (p=0.003), poor rating of marriages (p=0.03),
      difficulty being excited by fantasies (p=0.0001), increased vaginal dryness in
      the preceding one year (p=0.02), reduced frequency of sexual contact in the last 
      one year (p=0.04) and rejection of partner sexual advance (p=0.05). The
      proportion of women in regular sexual relationship was less among the
      hypertensive group (p=0.02). Use of drugs produced significant sexual
      unpleasantness (p=0.03). CONCLUSION: hypertension and its treatment may produce
      female sexual dysfunction, and should be considered in managing the female
      hypertensive. By so doing, quality of life can be maintained; and compliance
      improved upon. The cumulative effect would be improvement in blood pressure
      control, with its attendant reduction in morbidity and mortality from
      hypertension.
FAU - Okeahialam, B N
AU  - Okeahialam BN
AD  - Department of Medicine, Jos University Teaching Hospital, Jos, Nigeria.
      basokeam@yahoo.com
FAU - Ogbonna, C
AU  - Ogbonna C
LA  - eng
PT  - Journal Article
PL  - Nigeria
TA  - West Afr J Med
JT  - West African journal of medicine
JID - 8301891
RN  - 0 (Antihypertensive Agents)
SB  - IM
MH  - Adult
MH  - Antihypertensive Agents/*adverse effects
MH  - Blood Pressure/physiology
MH  - Coitus
MH  - Female
MH  - Humans
MH  - Hypertension/*drug therapy/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Nigeria/epidemiology
MH  - Orgasm
MH  - Prevalence
MH  - Quality of Life
MH  - Sexual Dysfunction, Physiological/epidemiology/*etiology
MH  - Sexual Dysfunctions, Psychological/epidemiology/*etiology
MH  - Sexuality/*drug effects/physiology/psychology
MH  - Surveys and Questionnaires
MH  - Vagina/physiopathology
MH  - Young Adult
EDAT- 2010/11/23 06:00
MHDA- 2011/03/03 06:00
CRDT- 2010/11/20 06:00
PHST- 2010/11/20 06:00 [entrez]
PHST- 2010/11/23 06:00 [pubmed]
PHST- 2011/03/03 06:00 [medline]
PST - ppublish
SO  - West Afr J Med. 2010 Sep-Oct;29(5):344-8.


PMID- 21088921
OWN - NLM
STAT- MEDLINE
DCOM- 20120919
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 18
IP  - 2
DP  - 2012 Jun
TI  - Going public: good scientific conduct.
PG  - 173-97
LID - 10.1007/s11948-010-9247-x [doi]
AB  - The paper addresses issues of scientific conduct regarding relations between
      science and the media, relations between scientists and journalists, and
      attitudes towards the public at large. In the large and increasing body of
      literature on scientific conduct and misconduct, these issues seem underexposed
      as ethical challenges. Consequently, individual scientists here tend to be left
      alone with problems and dilemmas, with no guidance for good conduct. Ideas are
      presented about how to make up for this omission. Using a practical, ethical
      approach, the paper attempts to identify ways scientists might deal with ethical 
      public relations issues, guided by a norm or maxim of openness. Drawing on and
      rethinking the CUDOS codification of the scientific ethos, as it was worked out
      by Robert K. Merton in 1942, we propose that this, which is echoed in current
      codifications of norms for good scientific conduct, contains a tacit maxim of
      openness which may naturally be extended to cover the public relations of
      science. Discussing openness as access, accountability, transparency and
      receptiveness, the argumentation concentrates on the possible prevention of
      misconduct with respect to, on the one hand, sins of omission-withholding
      important information from the public-and, on the other hand, abuses of the
      authority of science in order to gain publicity. Statements from interviews with 
      scientists are used to illustrate how scientists might view the relevance of the 
      issues raised.
FAU - Meyer, Gitte
AU  - Meyer G
AD  - Danish Centre for Bioethics and Risk Assessment, Institute of Food and Resource
      Economics, University of Copenhagen, Rolighedsvej 25, 1958, Frederiksberg,
      Denmark. gitte@gittemeyer.eu
FAU - Sandoe, Peter
AU  - Sandoe P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101119
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Codes of Ethics
MH  - *Communication
MH  - *Ethics, Research
MH  - *Guidelines as Topic
MH  - Interviews as Topic
MH  - *Public Relations
MH  - Science/*ethics
MH  - *Scientific Misconduct
MH  - *Social Responsibility
EDAT- 2010/11/23 06:00
MHDA- 2012/09/20 06:00
CRDT- 2010/11/20 06:00
PHST- 2010/07/26 00:00 [received]
PHST- 2010/11/04 00:00 [accepted]
PHST- 2010/11/20 06:00 [entrez]
PHST- 2010/11/23 06:00 [pubmed]
PHST- 2012/09/20 06:00 [medline]
AID - 10.1007/s11948-010-9247-x [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2012 Jun;18(2):173-97. doi: 10.1007/s11948-010-9247-x. Epub 2010 
      Nov 19.


PMID- 21088660
OWN - NLM
STAT- MEDLINE
DCOM- 20110121
LR  - 20191111
IS  - 1947-6094 (Print)
IS  - 1947-6108 (Linking)
VI  - 6
IP  - 4
DP  - 2010 Nov-2011 Jan
TI  - Antibiotic prophylaxis for infective endocarditis: ethical care in the era of
      revised guidelines.
PG  - 48-52
LID - 1947-6108-6-4-48 [pii]
AB  - Beginning in 1955, the American Heart Association recommended antibiotic
      prophylaxis among patients with certain structural heart diseases to decrease the
      likelihood of infective endocarditis (IE) following dental procedures. Over the
      ensuing 52 years, the American College of Cardiology/American Heart Association
      (ACC/AHA) guidelines were revised to address gastrointestinal and genitourinary
      procedures and to modify the assessment of relative risks and specific regimens
      for prophylaxis. Throughout the various revisions, prophylaxis was recommended
      for individuals who were at increased risk of developing IE based on best
      evidence and consensus opinion, albeit in the absence of randomized controlled
      trials. In 2007, the AHA published a revised guideline statement dramatically
      restricting its recommendations for antibiotic prophylaxis against IE. In 2008,
      these views were incorporated in an ACC/AHA guideline update on the management of
      patients with heart valve disease. The revisions represent a dramatic shift in
      terms of the patients for whom antibiotic prophylaxis is recommended and the
      procedures for which it is recommended. What is striking about the new guidelines
      is that the change in recommendations was based not on new data, but on a change 
      in philosophy despite the lack of new data. To some degree, the arguments for and
      against antibiotic prophylaxis become those of philosophy, ethics, and the role
      of evidence-based medicine. This manuscript attempts to briefly examine those
      arguments and discuss why the revised guidelines may fail to respect the ethical 
      principles of beneficence and patient autonomy.
FAU - Bach, David S
AU  - Bach DS
AD  - University of Michigan, Ann Arbor, Michigan, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Methodist Debakey Cardiovasc J
JT  - Methodist DeBakey cardiovascular journal
JID - 101508600
SB  - IM
MH  - American Heart Association
MH  - Animals
MH  - Antibiotic Prophylaxis/*ethics
MH  - Attitude of Health Personnel
MH  - Endocarditis/etiology/*prevention & control
MH  - Evidence-Based Medicine/ethics
MH  - Guideline Adherence/*ethics
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Patient Education as Topic/ethics
MH  - Patient Selection/ethics
MH  - Personal Autonomy
MH  - *Practice Guidelines as Topic
MH  - Risk Assessment
MH  - Risk Factors
MH  - United States
EDAT- 2010/11/23 06:00
MHDA- 2011/01/22 06:00
CRDT- 2010/11/20 06:00
PHST- 2010/11/20 06:00 [entrez]
PHST- 2010/11/23 06:00 [pubmed]
PHST- 2011/01/22 06:00 [medline]
AID - 10.14797/mdcj-6-4-48 [doi]
PST - ppublish
SO  - Methodist Debakey Cardiovasc J. 2010 Nov-2011 Jan;6(4):48-52. doi:
      10.14797/mdcj-6-4-48.


PMID- 21088098
OWN - NLM
STAT- MEDLINE
DCOM- 20110330
LR  - 20101220
IS  - 1744-5019 (Electronic)
IS  - 0360-5310 (Linking)
VI  - 35
IP  - 6
DP  - 2010 Dec
TI  - Transhumanism, metaphysics, and the posthuman god.
PG  - 700-20
LID - 10.1093/jmp/jhq047 [doi]
AB  - After describing Heidegger's critique of metaphysics as ontotheology, I unpack
      the metaphysical assumptions of several transhumanist philosophers. I claim that 
      they deploy an ontology of power and that they also deploy a kind of theology, as
      Heidegger meant it. I also describe the way in which this metaphysics begets its 
      own politics and ethics. In order to transcend the human condition, they must
      transgress the human.
FAU - Bishop, Jeffrey P
AU  - Bishop JP
AD  - Albert Gnaegi Center for Health Care Ethics, Saint Louis University, 3545
      Lafayette Avenue, St. Louis, MO 63104, USA. jbisho12@slu.edu
LA  - eng
PT  - Journal Article
DEP - 20101118
PL  - United States
TA  - J Med Philos
JT  - The Journal of medicine and philosophy
JID - 7610512
SB  - IM
MH  - Biological Evolution
MH  - Biomedical Enhancement/ethics
MH  - *Humanism
MH  - Humans
MH  - *Metaphysics
MH  - *Philosophy, Medical
MH  - *Religion
EDAT- 2010/11/23 06:00
MHDA- 2011/03/31 06:00
CRDT- 2010/11/20 06:00
PHST- 2010/11/20 06:00 [entrez]
PHST- 2010/11/23 06:00 [pubmed]
PHST- 2011/03/31 06:00 [medline]
AID - jhq047 [pii]
AID - 10.1093/jmp/jhq047 [doi]
PST - ppublish
SO  - J Med Philos. 2010 Dec;35(6):700-20. doi: 10.1093/jmp/jhq047. Epub 2010 Nov 18.


PMID- 21087731
OWN - NLM
STAT- MEDLINE
DCOM- 20110314
LR  - 20160603
IS  - 1532-4036 (Electronic)
IS  - 0964-3397 (Linking)
VI  - 26
IP  - 6
DP  - 2010 Dec
TI  - Diarrhoea risk factors in enterally tube fed critically ill patients: a
      retrospective audit.
PG  - 327-34
LID - 10.1016/j.iccn.2010.08.001 [doi]
AB  - OBJECTIVE: Diarrhoea in the enterally tube fed (ETF) intensive care unit (ICU)
      patient is a multi-factorial problem. Diarrhoeal aetiologies in this patient
      cohort remain debatable; however, the consequences of diarrhoea have been well
      established and include electrolyte imbalance, dehydration, bacterial
      translocation, peri anal wound contamination and sleep deprivation. This study
      examined the incidence of diarrhoea and explored factors contributing to the
      development of diarrhoea in the ETF, critically ill, adult patient. METHOD: After
      institutional ethical review and approval, a single centre medical chart audit
      was undertaken to examine the incidence of diarrhoea in ETF, critically ill
      patients. Retrospective, non-probability sequential sampling was used of all
      emergency admission adult ICU patients who met the inclusion/exclusion criteria. 
      RESULTS: Fifty patients were audited. Faecal frequency, consistency and quantity 
      were considered important criteria in defining ETF diarrhoea. The incidence of
      diarrhoea was 78%. Total patient diarrhoea days (r=0.422; p=0.02) and total
      diarrhoea frequency (r=0.313; p=0.027) increased when the patient was ETF for
      longer periods of time. Increased severity of illness, peripheral oxygen
      saturation (Sp02), glucose control, albumin and white cell count were found to be
      statistically significant factors for the development of diarrhoea. CONCLUSION:
      Diarrhoea in ETF critically ill patients is multi-factorial. The early
      identification of diarrhoea risk factors and the development of a diarrhoea risk 
      management algorithm is recommended.
CI  - Copyright (c) 2010. Published by Elsevier Ltd.
FAU - Jack, Leanne
AU  - Jack L
AD  - Queensland University of Technology, School of Nursing, Victoria Park Road,
      Kelvin Grove, Queensland 4059, Australia. lc.jack@student.qut.edu.au
FAU - Coyer, Fiona
AU  - Coyer F
FAU - Courtney, Mary
AU  - Courtney M
FAU - Venkatesh, Bala
AU  - Venkatesh B
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Intensive Crit Care Nurs
JT  - Intensive & critical care nursing
JID - 9211274
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Critical Illness
MH  - Diarrhea/drug therapy/*etiology
MH  - Enteral Nutrition/*adverse effects
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Young Adult
EDAT- 2010/11/23 06:00
MHDA- 2011/03/15 06:00
CRDT- 2010/11/20 06:00
PHST- 2009/11/04 00:00 [received]
PHST- 2010/07/24 00:00 [revised]
PHST- 2010/08/02 00:00 [accepted]
PHST- 2010/11/20 06:00 [entrez]
PHST- 2010/11/23 06:00 [pubmed]
PHST- 2011/03/15 06:00 [medline]
AID - S0964-3397(10)00066-2 [pii]
AID - 10.1016/j.iccn.2010.08.001 [doi]
PST - ppublish
SO  - Intensive Crit Care Nurs. 2010 Dec;26(6):327-34. doi: 10.1016/j.iccn.2010.08.001.


PMID- 21086699
OWN - NLM
STAT- MEDLINE
DCOM- 20110103
LR  - 20101116
IS  - 1592-7830 (Print)
IS  - 1592-7830 (Linking)
VI  - 32
IP  - 4
DP  - 2010 Oct-Dec
TI  - [Ideas, reflections and tools for a modern role of the occupational physician].
PG  - 437-40
AB  - Over the last few years, following new legislations, events of media impact,
      transitions in workplaces, Occupational Medicine is at stake. Often, debate is
      strong about technical-scientific issues in Occupational Physician (OP)
      activities, ethics and deontology, professional independence, dignity, training
      and education. The present work develops through personal thoughts, literature
      data, reporting of concrete personal experience across various occupational
      settings and risks, with the aim of promoting a "new" role for the OP, enhance
      his autonomy, professional skills, uniqueness, quality, credibility, while being 
      convinced that it is certainly necessary and possible to conjugate ethics and
      scientific approach within daily professional activity of the OP, who in turn
      should be prone to change pace, evaluate effectiveness of his actions, abandon
      obsolete and useless practices, focussing on a new, proactive,
      clinical-diagnostic and managerial role, through good medical practices.
FAU - Porru, S
AU  - Porru S
AD  - Dipartimento di Medicina Sperimentale ed Applicata-Sezione di Medicina del
      Lavoro, Universita degli Studi di Brescia, P.le Spedali Civili, 1-25123 Brescia. 
      porru@med.unibs.it
FAU - di Carlo, A Scotto
AU  - di Carlo AS
FAU - Arici, C
AU  - Arici C
LA  - ita
PT  - English Abstract
PT  - Journal Article
TT  - Idee, riflessioni e strumenti operativi per un "nuovo ruolo del medico competente
      vo".
PL  - Italy
TA  - G Ital Med Lav Ergon
JT  - Giornale italiano di medicina del lavoro ed ergonomia
JID - 9712708
SB  - IM
MH  - Occupational Medicine/*standards/trends
MH  - Physician's Role
EDAT- 2010/11/23 06:00
MHDA- 2011/01/05 06:00
CRDT- 2010/11/20 06:00
PHST- 2010/11/20 06:00 [entrez]
PHST- 2010/11/23 06:00 [pubmed]
PHST- 2011/01/05 06:00 [medline]
PST - ppublish
SO  - G Ital Med Lav Ergon. 2010 Oct-Dec;32(4):437-40.


PMID- 21086658
OWN - NLM
STAT- MEDLINE
DCOM- 20101210
LR  - 20191210
IS  - 0035-1334 (Print)
IS  - 0035-1334 (Linking)
VI  - 131
IP  - 1
DP  - 2010
TI  - [Evaluation in clinical practice of the quality of life of patients with VADS
      cancer: an ethical justification or a fad?].
PG  - 45-50
AB  - Now that the treatment of head and neck cancer has been perfectly standardized
      and the complications and sequelae are well known, many authors have started to
      investigate health-related quality of life (QoL). The use of generic and
      cancer-specific QoL instruments remains limited to the field of research, but can
      this approach be transposed to clinical oncology? This study was designed to
      answer this question by identifying the ethical problems related to QoL
      assessment. The methodology used is based on a questionnaire survey of a cohort
      of 40 volunteer patients, conducted some time after their initial treatment in
      order to optimally assess their expectations and questions in relation to these
      aspects. The validity of the instrumental approach cannot be guaranteed due to
      conceptual limits, and the sociocultural level and cognitive state of the target 
      population. A more subtle approach to QoL assessment in routine clinical practice
      would consist of a mixed approach harmoniously combining quantitative and
      qualitative aspects based on questionnaire and interview.
FAU - Moizan, H
AU  - Moizan H
AD  - CHR Metz, Laboratoire Ethique Medicale et Medecine Legale, Odontologiste des
      Hopitaux, 45 rue des Saints-Peres, 75006 Paris, France. herve.moizan@gmail.com
FAU - Mouret, P
AU  - Mouret P
FAU - Schraub, S
AU  - Schraub S
FAU - Herve, C
AU  - Herve C
LA  - fre
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
TT  - Evaluation en pratique clinique de la qualite de vie des patients atteints de
      cancers des V.A.D.S.: une demarche ethique justifiee ou un effet de mode?
PL  - France
TA  - Rev Laryngol Otol Rhinol (Bord)
JT  - Revue de laryngologie - otologie - rhinologie
JID - 0414144
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cohort Studies
MH  - Female
MH  - Head and Neck Neoplasms/*therapy
MH  - Health Surveys/*ethics
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Middle Aged
MH  - *Quality of Life
MH  - Socioeconomic Factors
MH  - Surveys and Questionnaires
EDAT- 2010/11/23 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/11/20 06:00
PHST- 2010/11/20 06:00 [entrez]
PHST- 2010/11/23 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - Rev Laryngol Otol Rhinol (Bord). 2010;131(1):45-50.


PMID- 21088562
OWN - NLM
STAT- MEDLINE
DCOM- 20110317
LR  - 20101122
IS  - 1538-8662 (Electronic)
IS  - 0361-1817 (Linking)
VI  - 35
IP  - 12
DP  - 2010 Dec
TI  - Advance care plans for CPR or mechanical ventilation in patients with dementia.
PG  - 38-42
LID - 10.1097/01.NPR.0000390436.13252.81 [doi]
AB  - Early development of advance care plans is an ethical and supportive intervention
      providers can offer patients and families facing a dementia diagnosis.
FAU - Westenhaver, Teresa F
AU  - Westenhaver TF
AD  - University of Illinois at Chicago, USA.
FAU - Krassa, Teresa J
AU  - Krassa TJ
FAU - Bonner, Gloria J
AU  - Bonner GJ
FAU - Wilkie, Diana J
AU  - Wilkie DJ
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Nurse Pract
JT  - The Nurse practitioner
JID - 7603663
SB  - IM
MH  - *Advance Care Planning
MH  - Aged
MH  - Aged, 80 and over
MH  - *Cardiopulmonary Resuscitation
MH  - Decision Making
MH  - Dementia/*nursing
MH  - Female
MH  - Humans
MH  - Male
MH  - Nurse Practitioners
MH  - *Professional-Family Relations
MH  - Proxy
MH  - *Respiration, Artificial
EDAT- 2010/11/20 06:00
MHDA- 2011/03/18 06:00
CRDT- 2010/11/20 06:00
PHST- 2010/11/20 06:00 [entrez]
PHST- 2010/11/20 06:00 [pubmed]
PHST- 2011/03/18 06:00 [medline]
AID - 10.1097/01.NPR.0000390436.13252.81 [doi]
AID - 00006205-201012000-00011 [pii]
PST - ppublish
SO  - Nurse Pract. 2010 Dec;35(12):38-42. doi: 10.1097/01.NPR.0000390436.13252.81.


PMID- 21085938
OWN - NLM
STAT- MEDLINE
DCOM- 20110727
LR  - 20211020
IS  - 1432-1041 (Electronic)
IS  - 0031-6970 (Linking)
VI  - 67 Suppl 1
DP  - 2011 May
TI  - Clinical research in newborn infants: difficulties and specificity.
PG  - 29-32
LID - 10.1007/s00228-010-0921-3 [doi]
AB  - BACKGROUND: Clinical trials are essential in neonates to evaluate scientifically 
      the efficacy and safety of drugs. However, major specificities condition clinical
      research in human neonates. OBJECTIVE: To review specific constraints to be taken
      into account in neonatal research studies. METHODS: A review of the literature
      and contribution of authors' opinions was carried out. RESULTS AND CONCLUSION:
      Neonatal specificities that induce obstacles in neonatal studies and proposals
      are detailed. This review also looks at recommendations recently developed by the
      European Commission to promote safe and ethical research in neonatology.
FAU - Ligi, Isabelle
AU  - Ligi I
AD  - Division of Neonatology, La Conception Hospital, Assistance Publique-Hopitaux de 
      Marseille and Faculte de Medecine, Universite de la Mediterranee, Marseille,
      France.
FAU - Boubred, Farid
AU  - Boubred F
FAU - Grandvuillemin, Isabelle
AU  - Grandvuillemin I
FAU - Simeoni, Umberto
AU  - Simeoni U
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20101118
PL  - Germany
TA  - Eur J Clin Pharmacol
JT  - European journal of clinical pharmacology
JID - 1256165
SB  - IM
MH  - Biomedical Research/*ethics/*methods
MH  - Clinical Trials as Topic/*ethics/*methods
MH  - Humans
MH  - *Infant, Newborn
MH  - Neonatology/*ethics/*methods
EDAT- 2010/11/19 06:00
MHDA- 2011/07/28 06:00
CRDT- 2010/11/19 06:00
PHST- 2010/06/23 00:00 [received]
PHST- 2010/10/10 00:00 [accepted]
PHST- 2010/11/19 06:00 [entrez]
PHST- 2010/11/19 06:00 [pubmed]
PHST- 2011/07/28 06:00 [medline]
AID - 10.1007/s00228-010-0921-3 [doi]
PST - ppublish
SO  - Eur J Clin Pharmacol. 2011 May;67 Suppl 1:29-32. doi: 10.1007/s00228-010-0921-3. 
      Epub 2010 Nov 18.


PMID- 21085850
OWN - NLM
STAT- MEDLINE
DCOM- 20110330
LR  - 20191111
IS  - 1809-4546 (Electronic)
IS  - 0100-6991 (Linking)
VI  - 37
IP  - 4
DP  - 2010 Aug
TI  - [Commitments of medicine: reflections on the prayer of Maimonides].
PG  - 306-7
LID - S0100-69912010000400013 [pii]
AB  - Science/art millennial, medicine involves, by its nature, a strong commitment to 
      basic principles of bioethics that are summarized in the pursuit of health and
      welfare of people and communities in their broadest sense. Such commitments may
      be more formal, such as obedience to the Codes of Ethics and Ethics; public, such
      as oaths, or consciousness, which are the prayers. The latter model is the Prayer
      of Maimonides, presented in this article.
FAU - Filho, Isac Jorge
AU  - Filho IJ
AD  - Departamento de Defesa Profissional, CBC.
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Os compromissos do medico: reflexoes sobre a oracao de Maimonides.
PL  - Brazil
TA  - Rev Col Bras Cir
JT  - Revista do Colegio Brasileiro de Cirurgioes
JID - 7809515
SB  - IM
MH  - *Ethics, Medical
MH  - Religion
EDAT- 2010/11/19 06:00
MHDA- 2011/03/31 06:00
CRDT- 2010/11/19 06:00
PHST- 2010/04/12 00:00 [received]
PHST- 2010/05/06 00:00 [accepted]
PHST- 2010/11/19 06:00 [entrez]
PHST- 2010/11/19 06:00 [pubmed]
PHST- 2011/03/31 06:00 [medline]
AID - S0100-69912010000400013 [pii]
AID - 10.1590/s0100-69912010000400013 [doi]
PST - ppublish
SO  - Rev Col Bras Cir. 2010 Aug;37(4):306-7. doi: 10.1590/s0100-69912010000400013.


PMID- 21085845
OWN - NLM
STAT- MEDLINE
DCOM- 20110330
LR  - 20191111
IS  - 1809-4546 (Electronic)
IS  - 0100-6991 (Linking)
VI  - 37
IP  - 4
DP  - 2010 Aug
TI  - [Expensive therapy of vascular trauma].
PG  - 279-83
LID - S0100-69912010000400008 [pii]
AB  - OBJECTIVE: To analyze all expenses paid to the first surgical approached for
      vascular lesion patients admitted at Hospital Joao XXIII/FHEMIG, between years
      2004 until 2006. METHOD: It is about an ethical approved study, retrospective and
      descriptive from audit over 70 eligible patients enrolled by Cardiovascular
      Service. RESULTS: Five (7.14%) patient's files were excluded for bad quality
      records. The costs were R$ 103,614.96 (US$ 60,949.97) and R$ 185,888.21 (US$
      109,346.0), a 44% sliding scale for endowment from Brazilian Public System and
      private medical assistance estimate, respectively. Indeed, the data showed direct
      relationship between costs and anatomic topographic and exponential increased
      expenses when blood and/or vascular prosthesis were utilized. CONCLUSION: Audit
      in health system is a must to making decision and evidences the expensive therapy
      for vascular lesions.
FAU - Costa-Val, Ricardo
AU  - Costa-Val R
AD  - FHEMIG, Belo Horizonte, MG, BR. ricardocostaval@hotmail.com
FAU - Marques, Maria Cristina
AU  - Marques MC
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Altos custos financeiros do trauma vascular.
PL  - Brazil
TA  - Rev Col Bras Cir
JT  - Revista do Colegio Brasileiro de Cirurgioes
JID - 7809515
SB  - IM
MH  - Blood Vessels/*injuries
MH  - Cohort Studies
MH  - Costs and Cost Analysis
MH  - Humans
MH  - Retrospective Studies
MH  - Vascular Surgical Procedures/economics
EDAT- 2010/11/19 06:00
MHDA- 2011/03/31 06:00
CRDT- 2010/11/19 06:00
PHST- 2009/05/08 00:00 [received]
PHST- 2009/07/10 00:00 [accepted]
PHST- 2010/11/19 06:00 [entrez]
PHST- 2010/11/19 06:00 [pubmed]
PHST- 2011/03/31 06:00 [medline]
AID - S0100-69912010000400008 [pii]
AID - 10.1590/s0100-69912010000400008 [doi]
PST - ppublish
SO  - Rev Col Bras Cir. 2010 Aug;37(4):279-83. doi: 10.1590/s0100-69912010000400008.


PMID- 21085840
OWN - NLM
STAT- MEDLINE
DCOM- 20110330
LR  - 20191111
IS  - 1809-4546 (Electronic)
IS  - 0100-6991 (Linking)
VI  - 37
IP  - 4
DP  - 2010 Aug
TI  - [Frequency of vomiting after emergency abdominal surgery in a reference public
      hospital].
PG  - 256-9
LID - S0100-69912010000400003 [pii]
AB  - OBJECTIVE: The objective of this study was to evaluate the frequency of the
      vomiting after urgency abdominal surgery in the Alagoas reference public
      hospital. METHODS: After approved in the Ethic and Search Committee of the
      Alagoas Federal University, the information was got in the medical records 24
      hours after urgency abdominal surgery. Fisher test and chi-square with Yates
      correction were used do compare proportions assuming a 5% significance level. Was
      calculated 95% confidence interval to proportions when was possible. RESULTS:
      Were 100 patients, 85% men (85/100, CI 95% 0.78-0.92). The vomiting frequency was
      25% without statistical difference between abdominal surgery after trauma and
      inflammatory acute abdomen (P=0.46). There was not statistical difference between
      anesthetic techniques (P=0.99). CONCLUSION: The general vomiting prevalence after
      the urgency abdominal surgery in the Alagoas reference public hospital was 25%.
FAU - Barbosa, Fabiano Timbo
AU  - Barbosa FT
AD  - Centro de Ensino e Treinamento, Obras Sociais Irma Dulce, Salvador, BA, BR.
      fabianotimbo@yahoo.com.br
FAU - Brandao, Roberta Ribeiro Marques
AU  - Brandao RR
FAU - Almeida, Roberta Louise Kunzler A de
AU  - Almeida RL
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Frequencia do vomito apos cirurgia abdominal de urgencia em hospital publico de
      referencia.
PL  - Brazil
TA  - Rev Col Bras Cir
JT  - Revista do Colegio Brasileiro de Cirurgioes
JID - 7809515
SB  - IM
MH  - Abdomen/*surgery
MH  - Adolescent
MH  - Adult
MH  - Emergency Treatment
MH  - Female
MH  - Hospitals, Public
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Postoperative Nausea and Vomiting/*epidemiology
MH  - Young Adult
EDAT- 2010/11/19 06:00
MHDA- 2011/03/31 06:00
CRDT- 2010/11/19 06:00
PHST- 2009/04/24 00:00 [received]
PHST- 2009/07/01 00:00 [accepted]
PHST- 2010/11/19 06:00 [entrez]
PHST- 2010/11/19 06:00 [pubmed]
PHST- 2011/03/31 06:00 [medline]
AID - S0100-69912010000400003 [pii]
AID - 10.1590/s0100-69912010000400003 [doi]
PST - ppublish
SO  - Rev Col Bras Cir. 2010 Aug;37(4):256-9. doi: 10.1590/s0100-69912010000400003.


PMID- 21084415
OWN - NLM
STAT- MEDLINE
DCOM- 20110110
LR  - 20111025
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 257
IP  - 3
DP  - 2010 Dec
TI  - Diffusion-weighted MR imaging of the placenta in fetuses with placental
      insufficiency.
PG  - 810-9
LID - 10.1148/radiol.10092283 [doi]
AB  - PURPOSE: To evaluate diffusion-weighted magnetic resonance (MR) imaging of the
      human placenta in fetuses with and fetuses without intrauterine growth
      restriction (IUGR) who were suspected of having placental insufficiency.
      MATERIALS AND METHODS: The study was approved by the local ethics committee, and 
      written informed consent was obtained. The authors retrospectively evaluated
      1.5-T fetal MR images from 102 singleton pregnancies (mean gestation +/- standard
      deviation, 29 weeks +/- 5; range, 21-41 weeks). Morphologic and
      diffusion-weighted MR imaging were performed. A region of interest analysis of
      the apparent diffusion coefficient (ADC) of the placenta was independently
      performed by two observers who were blinded to clinical data and outcome.
      Placental insufficiency was diagnosed if flattening of the growth curve was
      detected at obstetric ultrasonography (US), if the birth weight was in the 10th
      percentile or less, or if fetal weight estimated with US was below the 10th
      percentile. Abnormal findings at Doppler US of the umbilical artery and
      histopathologic examination of specimens from the placenta were recorded. The
      ADCs in fetuses with placental insufficiency were compared with those in fetuses 
      of the same gestational age without placental insufficiency and tested for normal
      distribution. The t tests and Pearson correlation coefficients were used to
      compare these results at 5% levels of significance. RESULTS: Thirty-three of the 
      102 pregnancies were ultimately categorized as having an insufficient placenta.
      MR imaging depicted morphologic changes (eg, infarction or bleeding) in 27
      fetuses. Placental dysfunction was suspected in 33 fetuses at diffusion-weighted 
      imaging (mean ADC, 146.4 sec/mm(2) +/- 10.63 for fetuses with placental
      insufficiency vs 177.1 sec/mm(2) +/- 18.90 for fetuses without placental
      insufficiency; P < .01, with one false-positive case). The use of
      diffusion-weighted imaging in addition to US increased sensitivity for the
      detection of placental insufficiency from 73% to 100%, increased accuracy from
      91% to 99%, and preserved specificity at 99%. CONCLUSION: Placental dysfunction
      associated with growth restriction is associated with restricted diffusion and
      reduced ADC. A decreased ADC used as an early marker of placental damage might be
      indicative of pregnancy complications such as IUGR. SUPPLEMENTAL MATERIAL:
      http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.10092283/-/DC1.
CI  - (c) RSNA, 2010
FAU - Bonel, Harald Marcel
AU  - Bonel HM
AD  - Institute for Diagnostic, Interventional and Pediatric Radiology, Inselspital,
      University of Bern, Freiburgstrasse 10, 3010 Bern, Switzerland. bonel@gmx.ch
FAU - Stolz, Bernhard
AU  - Stolz B
FAU - Diedrichsen, Lars
AU  - Diedrichsen L
FAU - Frei, Kathrin
AU  - Frei K
FAU - Saar, Bettina
AU  - Saar B
FAU - Tutschek, Boris
AU  - Tutschek B
FAU - Raio, Luigi
AU  - Raio L
FAU - Surbek, Daniel
AU  - Surbek D
FAU - Srivastav, Sudesh
AU  - Srivastav S
FAU - Nelle, Mathias
AU  - Nelle M
FAU - Slotboom, Johannes
AU  - Slotboom J
FAU - Wiest, Roland
AU  - Wiest R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
CIN - Radiology. 2011 Jul;260(1):303; author reply 303-4. PMID: 21697311
CIN - Radiology. 2011 Oct;261(1):333; author reply 333-4. PMID: 21931150
EIN - Radiology. 2011 Jul;260(1):308
MH  - Adult
MH  - Diffusion Magnetic Resonance Imaging/*methods
MH  - Female
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Placental Insufficiency/*diagnosis
MH  - Pregnancy
MH  - Pregnancy Outcome
MH  - Retrospective Studies
MH  - Statistics, Nonparametric
MH  - Ultrasonography, Prenatal
EDAT- 2010/11/19 06:00
MHDA- 2011/01/11 06:00
CRDT- 2010/11/19 06:00
PHST- 2010/11/19 06:00 [entrez]
PHST- 2010/11/19 06:00 [pubmed]
PHST- 2011/01/11 06:00 [medline]
AID - 257/3/810 [pii]
AID - 10.1148/radiol.10092283 [doi]
PST - ppublish
SO  - Radiology. 2010 Dec;257(3):810-9. doi: 10.1148/radiol.10092283.


PMID- 21084356
OWN - NLM
STAT- MEDLINE
DCOM- 20110429
LR  - 20101214
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 1
DP  - 2011 Jan
TI  - The moral primacy of the human being: a reply to Parker.
PG  - 56-7
LID - 10.1136/jme.2010.040345 [doi]
AB  - In a previous paper in the Journal of Medical Ethics, the authors argued that the
      research ethical principle stating that the individual shall have priority over
      science, found in many guidelines, is utterly unclear and because of this should 
      be explicated or otherwise deleted. In a recent commentary, Parker argued that
      this leaves us defending a position that would allow totalitarian regimes to
      pursue glory at the expense of its citizens. The present response addresses this 
      and similar accusations.
FAU - Helgesson, Gert
AU  - Helgesson G
AD  - Stockholm Centre for Healthcare Ethics (CHE), Department of Learning,
      Informatics, Management, and Ethics, Karolinska Institutet, SE-171 77 Stockholm, 
      Sweden. gert.helgesson@ki.se
FAU - Eriksson, Stefan
AU  - Eriksson S
LA  - eng
PT  - Comment
PT  - Journal Article
DEP - 20101117
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
CON - J Med Ethics. 2010 Sep;36(9):563-6. PMID: 20693483
MH  - *Conflict of Interest
MH  - Humans
MH  - *Moral Obligations
MH  - Personal Autonomy
MH  - *Research Subjects/psychology
MH  - Science/*ethics
MH  - Therapeutic Human Experimentation/*ethics
EDAT- 2010/11/19 06:00
MHDA- 2011/04/30 06:00
CRDT- 2010/11/19 06:00
PHST- 2010/11/19 06:00 [entrez]
PHST- 2010/11/19 06:00 [pubmed]
PHST- 2011/04/30 06:00 [medline]
AID - jme.2010.040345 [pii]
AID - 10.1136/jme.2010.040345 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Jan;37(1):56-7. doi: 10.1136/jme.2010.040345. Epub 2010 Nov
      17.


PMID- 21084354
OWN - NLM
STAT- MEDLINE
DCOM- 20110519
LR  - 20220408
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 3
DP  - 2011 Mar
TI  - Ethical dilemmas in medical humanitarian practice: cases for reflection from
      Medecins Sans Frontieres.
PG  - 162-5
LID - 10.1136/jme.2010.038448 [doi]
AB  - Medecins Sans Frontieres (MSF) is an independent medical humanitarian
      organisation working in over 70 countries. It has provided medical assistance for
      over 35&emsp14;years to populations vulnerable through conflict, disease and
      inadequate health systems. Medical ethics define the starting point of the
      relationship between medical staff and patients. The ethics of humanitarian
      interventions and of research in conflict settings are much debated. However,
      less is known about the ethical dilemmas faced by medical humanitarian staff in
      their daily work. Ethical dilemmas can be intensified in humanitarian contexts by
      insecure environments, lack of optimum care, language barriers, potentially
      heightened power discrepancies between care providers and patients, differing
      cultural values and perceptions of patients, communities and medical staff. Time 
      constraints, stressful conditions and lack of familiarity with ethical frameworks
      can prevent reflection on these dilemmas, as can frustration that such reflection
      does not necessarily provide instant solutions. Lack of reflection, however, can 
      be distressing for medical practitioners and can reduce the quality of care.
      Ethical reflection has a central role in MSF, and the organisation uses ethical
      frameworks to help with clinical and programmatic decisions as well as in
      deliberations over operational research. We illustrate and discuss some real
      ethical dilemmas facing MSF teams. Only by sharing and seeking guidance can MSF
      and similar actors make more thoughtful and appropriate decisions. Our aim in
      sharing these cases is to invite discussion and dialogue in the wider medical
      community working in crisis, conflict or with severe resource limitations.
FAU - Sheather, Julian
AU  - Sheather J
AD  - British Medical Association, Ethics Department, BMA House, London, UK.
FAU - Shah, Tejshri
AU  - Shah T
LA  - eng
PT  - Journal Article
DEP - 20101117
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Altruism
MH  - *Attitude of Health Personnel
MH  - Cross-Cultural Comparison
MH  - Delivery of Health Care/standards
MH  - Developing Countries
MH  - *Ethics, Medical
MH  - Humans
MH  - International Agencies/*ethics
MH  - Medical Missions/*ethics
MH  - Patient Rights/*ethics
EDAT- 2010/11/19 06:00
MHDA- 2011/05/20 06:00
CRDT- 2010/11/19 06:00
PHST- 2010/11/19 06:00 [entrez]
PHST- 2010/11/19 06:00 [pubmed]
PHST- 2011/05/20 06:00 [medline]
AID - jme.2010.038448 [pii]
AID - 10.1136/jme.2010.038448 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Mar;37(3):162-5. doi: 10.1136/jme.2010.038448. Epub 2010 Nov
      17.


PMID- 21083913
OWN - NLM
STAT- MEDLINE
DCOM- 20110110
LR  - 20211020
IS  - 1746-4269 (Electronic)
IS  - 1746-4269 (Linking)
VI  - 6
DP  - 2010 Nov 17
TI  - The relevance of traditional knowledge systems for ethnopharmacological research:
      theoretical and methodological contributions.
PG  - 32
LID - 10.1186/1746-4269-6-32 [doi]
AB  - BACKGROUND: Ethnopharmacology is at the intersection of the medical, natural, and
      social sciences. Despite its interdisciplinary nature, most ethnopharmacological 
      research has been based on the combination of the chemical, biological, and
      pharmacological sciences. Far less attention has been given to the social
      sciences, including anthropology and the study of traditional knowledge systems. 
      METHODS: I reviewed the literature on traditional knowledge systems highlighting 
      its potential theoretical and methodological contributions to ethnopharmacology. 
      RESULTS: I discuss three potential theoretical contributions of traditional
      knowledge systems to ethnopharmacological research. First, while many plants used
      in indigenous pharmacopoeias have active compounds, those compounds do not always
      act alone in indigenous healing systems. Research highlights the holistic nature 
      of traditional knowledge systems and helps understand plant's efficacy in its
      cultural context. Second, research on traditional knowledge systems can improve
      our understanding of how ethnopharmacological knowledge is distributed in a
      society, and who benefits from it. Third, research on traditional knowledge
      systems can enhance the study of the social relations that enable the generation,
      maintenance, spread, and devolution of cultural traits and innovations, including
      ethnopharmacological knowledge. At a methodological level, some
      ethnopharmacologists have used anthropological tools to understand the context of
      plant use and local meanings of health and disease. I discuss two more potential 
      methodological contributions of research on traditional knowledge systems to
      ethnopharmacological research. First, traditional knowledge systems research has 
      developed methods that would help ethnopharmacologists understand how people
      classify illnesses and remedies, a fundamental aspect of folk medicinal plant
      selection criteria. Second, ethnopharmacologists could also borrow methods
      derived from cultural consensus theory to have a broader look at intracultural
      variation and at the analysis of transmission and loss of traditional
      ethnopharmacological knowledge. CONCLUSIONS: Ethical considerations in the
      ethnopharmacology of the 21st century should go beyond the recognition of the
      Intellectual Property Rights or the acquisition of research permits, to include
      considerations on the healthcare of the original holders of ethnopharmacological 
      knowledge. Ethnopharmacology can do more than speed up to recover the traditional
      knowledge of indigenous peoples to make it available for the development of new
      drugs. Ethnopharmacologists can work with health care providers in the developing
      world for the local implementation of ethnopharmacological research results.
FAU - Reyes-Garcia, Victoria
AU  - Reyes-Garcia V
AD  - ICREA and Institut de Ciencia i Tecnologia Ambientals, Universitat Autonoma de
      Barcelona, 08193 Bellatera, Barcelona, Spain. victoria.reyes@uab.cat
LA  - eng
PT  - Journal Article
DEP - 20101117
PL  - England
TA  - J Ethnobiol Ethnomed
JT  - Journal of ethnobiology and ethnomedicine
JID - 101245794
SB  - IM
MH  - *Anthropology, Cultural
MH  - *Biomedical Research
MH  - Ethnopharmacology/ethics/*methods
MH  - Humans
MH  - *Medicine, Traditional
MH  - *Phytotherapy
MH  - *Research Design
PMC - PMC2993655
EDAT- 2010/11/19 06:00
MHDA- 2011/01/11 06:00
CRDT- 2010/11/19 06:00
PHST- 2010/10/01 00:00 [received]
PHST- 2010/11/17 00:00 [accepted]
PHST- 2010/11/19 06:00 [entrez]
PHST- 2010/11/19 06:00 [pubmed]
PHST- 2011/01/11 06:00 [medline]
AID - 1746-4269-6-32 [pii]
AID - 10.1186/1746-4269-6-32 [doi]
PST - epublish
SO  - J Ethnobiol Ethnomed. 2010 Nov 17;6:32. doi: 10.1186/1746-4269-6-32.


PMID- 21083383
OWN - NLM
STAT- MEDLINE
DCOM- 20101123
LR  - 20110311
IS  - 1533-4406 (Electronic)
IS  - 0028-4793 (Linking)
VI  - 363
IP  - 21
DP  - 2010 Nov 18
TI  - Up in the air--suspending ethical medical practice.
PG  - 1988-9
LID - 10.1056/NEJMp1006331 [doi]
FAU - Shaner, D Malcolm
AU  - Shaner DM
AD  - Department of Neurology, Kaiser Permanente Medical Care Program, West Los Angeles
      Medical Center, Los Angeles, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - N Engl J Med
JT  - The New England journal of medicine
JID - 0255562
SB  - IM
CIN - N Engl J Med. 2011 Mar 10;364(10):980; author reply 980. PMID: 21388330
MH  - Aerospace Medicine/ethics
MH  - Aviation/*ethics
MH  - Cardiopulmonary Resuscitation/*ethics
MH  - *Ethics, Institutional
MH  - *Ethics, Medical
MH  - Heart Arrest/therapy
MH  - Humans
MH  - Medical Futility/*ethics
EDAT- 2010/11/19 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/11/19 06:00
PHST- 2010/11/19 06:00 [entrez]
PHST- 2010/11/19 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1056/NEJMp1006331 [doi]
PST - ppublish
SO  - N Engl J Med. 2010 Nov 18;363(21):1988-9. doi: 10.1056/NEJMp1006331.


PMID- 21083366
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20161018
IS  - 1557-900X (Electronic)
IS  - 0892-7790 (Linking)
VI  - 25
IP  - 2
DP  - 2011 Feb
TI  - Management of the ventriculo-peritoneal shunt in pediatric patients during
      robot-assisted laparoscopic urologic procedures.
PG  - 225-9
LID - 10.1089/end.2010.0181 [doi]
AB  - INTRODUCTION: Infection or malfunction of ventriculo-peritoneal (VP) shunts is a 
      severe complication during laparoscopic surgery involving the gastrointestinal or
      urinary tract. It has been recently suggested to externalize the shunt or convert
      into a ventriculo-atrial shunt to prevent this complication with laparoscopic
      approach. Herein, we present a novel technique for management of the VP shunt
      during robot-assisted laparoscopic (RAL) urologic procedures. MATERIALS AND
      METHODS: After port placement and diagnostic peritoneoscopy, an Endopouch bag
      (Ethicon Endo-Surgery) was inserted into the peritoneal cavity and the distal end
      of the shunt was placed into the pouch. The Endopouch suture was synched around
      the shunt and the pouch was placed in the subhepatic space during the surgery.
      The intraperitoneal pressure was maintained at 12 mm Hg during the entire
      procedure. Metronidazole, gentamicin, and vancomycin were administered as
      prophylaxis. Following the completion of the surgery and profuse irrigation of
      the peritoneal cavity, the shunt was repositioned within the peritoneum. We
      evaluated perioperative shunt-related complications. RESULTS: We used this
      technique in four patients with VP shunt undergoing RAL cystoplasty and
      appendicovesicostomy and/or colonic enema channel formation. The average age of
      the patient at surgery was 10.8 (7-14) years. One patient was converted to open
      because of failure to progress due to multiple adhesions and the shunt was
      externalized temporarily. At a mean follow-up of 13 (3-20) months, no
      shunt-related complications were seen. CONCLUSIONS: In our preliminary
      experience, the use of an intracorporeal Endopouch bag with controlled
      pneumoperitoneal pressure to protect the VP shunt may be an effective alternative
      to prevent complications related to it during RAL urologic surgery involving the 
      gastrointestinal or urinary tract. Further studies will be needed to confirm our 
      results.
FAU - Marchetti, Pablo
AU  - Marchetti P
AD  - Pediatric Urology Section of Urology, Department of Surgery, Comer Children's
      Hospital, The University of Chicago Medical Center and Pritzker School of
      Medicine, Chicago, Illinois, USA. pemarchetti@yahoo.com
FAU - Razmaria, Aria
AU  - Razmaria A
FAU - Zagaja, Greg P
AU  - Zagaja GP
FAU - Gundeti, Mohan S
AU  - Gundeti MS
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20101117
PL  - United States
TA  - J Endourol
JT  - Journal of endourology
JID - 8807503
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Female
MH  - Humans
MH  - Intraoperative Care
MH  - *Laparoscopy
MH  - Male
MH  - Robotics/*methods
MH  - Urologic Surgical Procedures/*methods
MH  - Ventriculoperitoneal Shunt/*methods
EDAT- 2010/11/19 06:00
MHDA- 2011/06/03 06:00
CRDT- 2010/11/19 06:00
PHST- 2010/11/19 06:00 [entrez]
PHST- 2010/11/19 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
AID - 10.1089/end.2010.0181 [doi]
PST - ppublish
SO  - J Endourol. 2011 Feb;25(2):225-9. doi: 10.1089/end.2010.0181. Epub 2010 Nov 17.


PMID- 21082565
OWN - NLM
STAT- MEDLINE
DCOM- 20120816
LR  - 20101118
IS  - 1090-3941 (Print)
IS  - 1090-3941 (Linking)
VI  - 20
DP  - 2010 Oct
TI  - Current developments in hernia repair; meshes, adhesives, and tacking.
PG  - 175-81
AB  - Open and laparoscopic hernia surgery continues to evolve with new products
      allowing surgeons multiple choices in treating their patients. The evolution
      towards tension-free techniques in dealing with hernias requires that today's
      surgeons know the options available in meshes as well as fixation methods in
      order to have the best outcomes. In recent years, there has been a rapid
      expansion in the number of meshes available. Currently, there are numerous
      uncoated, coated, and biologic meshes in production that can be used in hernia
      repair. This paper will focus on the latest developments in coated meshes that
      allow for intra-abdominal placement as well as the different types of biologic
      meshes and their typical uses. Tacking devices for laparoscopic hernia repair now
      come in titanium as well as absorbable devices. AbsorbaTack (Covidien, Norwalk,
      CT) and Sorbafix (Davol, Warwick, RI) are two of the newest absorbable tacking
      devices thought to possibly benefit patients with decreased pain and long-term
      complications as compared with their titanium counterparts. Adhesives continue to
      be used more and more for hernia repair, especially in inguinal and
      paraesophageal hernia repairs. Tissucol/Tisseel (Baxter, Deerfield, IL) and
      Evicel (Ethicon, Somerville, NJ) are two types of fibrin glues that are available
      for use in hernia repair. Practitioners using these biologic adhesives think
      there is less pain compared with tacking.
FAU - Powell, Benjamin S
AU  - Powell BS
AD  - University of Tennessee Health Science Center, Memphis, TN, USA.
FAU - Voeller, Guy R
AU  - Voeller GR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Surg Technol Int
JT  - Surgical technology international
JID - 9604509
RN  - 0 (Fibrin Tissue Adhesive)
SB  - IM
MH  - Equipment Design
MH  - Fibrin Tissue Adhesive/*therapeutic use
MH  - Hernia/*therapy
MH  - Herniorrhaphy/*instrumentation/*methods
MH  - Humans
MH  - *Surgical Mesh
MH  - *Sutures
EDAT- 2010/11/18 06:00
MHDA- 2012/08/17 06:00
CRDT- 2010/11/18 06:00
PHST- 2010/11/18 06:00 [entrez]
PHST- 2010/11/18 06:00 [pubmed]
PHST- 2012/08/17 06:00 [medline]
PST - ppublish
SO  - Surg Technol Int. 2010 Oct;20:175-81.


PMID- 21081947
OWN - NLM
STAT- MEDLINE
DCOM- 20101214
LR  - 20201209
IS  - 1532-6535 (Electronic)
IS  - 0009-9236 (Linking)
VI  - 88
IP  - 6
DP  - 2010 Dec
TI  - Ethical considerations in CYP2D6 genotype testing for codeine-prescribed
      breastfeeding mothers.
PG  - 760-2
LID - 10.1038/clpt.2010.225 [doi]
AB  - In this issue, Madadi et al. report on interviews with codeine-prescribed
      breastfeeding mothers concerning preferences and attitudes toward receiving their
      CYP2D6 genotype and overall study findings. We address three sets of ethics
      questions raised by this article. Should genetic information be disclosed to
      research participants in genetic research? What should clinicians take into
      account when considering this genetic test in managing infant opioid toxicity
      risk? What conditions support or hinder the integration of genetic information
      into patient care?
FAU - Kurtz, M
AU  - Kurtz M
AD  - Yale-New Haven Hospital, New Haven, Connecticut, USA.
FAU - Black Golde, P
AU  - Black Golde P
FAU - Berlinger, N
AU  - Berlinger N
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Comment
PL  - United States
TA  - Clin Pharmacol Ther
JT  - Clinical pharmacology and therapeutics
JID - 0372741
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP2D6)
RN  - UX6OWY2V7J (Codeine)
SB  - IM
CON - Clin Pharmacol Ther. 2010 Dec;88(6):792-5. PMID: 20739920
MH  - *Breast Feeding
MH  - Codeine/pharmacokinetics/*therapeutic use
MH  - Cytochrome P-450 CYP2D6/*genetics
MH  - Female
MH  - Genetic Testing/*ethics
MH  - Genotype
MH  - Humans
MH  - Infant
EDAT- 2010/11/18 06:00
MHDA- 2010/12/16 06:00
CRDT- 2010/11/18 06:00
PHST- 2010/11/18 06:00 [entrez]
PHST- 2010/11/18 06:00 [pubmed]
PHST- 2010/12/16 06:00 [medline]
AID - clpt2010225 [pii]
AID - 10.1038/clpt.2010.225 [doi]
PST - ppublish
SO  - Clin Pharmacol Ther. 2010 Dec;88(6):760-2. doi: 10.1038/clpt.2010.225.


PMID- 21081679
OWN - NLM
STAT- MEDLINE
DCOM- 20110526
LR  - 20110202
IS  - 1558-9102 (Electronic)
IS  - 1092-4388 (Linking)
VI  - 54
IP  - 1
DP  - 2011 Feb
TI  - Research ethics II: Mentoring, collaboration, peer review, and data management
      and ownership.
PG  - S330-45
LID - 10.1044/1092-4388(2010/09-0264) [doi]
AB  - PURPOSE: In this series of articles--Research Ethics I, Research Ethics II, and
      Research Ethics III--the authors provide a comprehensive review of the 9 core
      domains for the responsible conduct of research (RCR) as articulated by the
      Office of Research Integrity. In Research Ethics II, the authors review the RCR
      domains of mentoring, collaboration, peer review, and data management and
      ownership. METHOD: They relied on authoritative documents, both historical and
      contemporary, insightful commentary, and empirical research in order to identify 
      current issues and controversies of potential interest to both faculty and
      students. CONCLUSIONS: The authors close by urging readers to stay abreast of the
      manifold ethics issues facing today's community of scientists, policymakers, and 
      research institutions, and to adhere to best practices as they evolve.
FAU - Horner, Jennifer
AU  - Horner J
AD  - College of Health Sciences and Professions, Ohio University, W380 Grover Center, 
      Athens, OH 45701, USA. hornerj@ohio.edu
FAU - Minifie, Fred D
AU  - Minifie FD
LA  - eng
GR  - NS44534/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20101116
PL  - United States
TA  - J Speech Lang Hear Res
JT  - Journal of speech, language, and hearing research : JSLHR
JID - 9705610
SB  - IM
MH  - Animals
MH  - Biomedical Research/*ethics
MH  - *Cooperative Behavior
MH  - Humans
MH  - *Intellectual Property
MH  - *Mentors
MH  - Peer Review/*ethics
EDAT- 2010/11/18 06:00
MHDA- 2011/05/27 06:00
CRDT- 2010/11/18 06:00
PHST- 2010/11/18 06:00 [entrez]
PHST- 2010/11/18 06:00 [pubmed]
PHST- 2011/05/27 06:00 [medline]
AID - 1092-4388_2010_09-0264 [pii]
AID - 10.1044/1092-4388(2010/09-0264) [doi]
PST - ppublish
SO  - J Speech Lang Hear Res. 2011 Feb;54(1):S330-45. doi:
      10.1044/1092-4388(2010/09-0264). Epub 2010 Nov 16.


PMID- 21081677
OWN - NLM
STAT- MEDLINE
DCOM- 20110526
LR  - 20110202
IS  - 1558-9102 (Electronic)
IS  - 1092-4388 (Linking)
VI  - 54
IP  - 1
DP  - 2011 Feb
TI  - Research ethics I: Responsible conduct of research (RCR)--historical and
      contemporary issues pertaining to human and animal experimentation.
PG  - S303-29
LID - 10.1044/1092-4388(2010/09-0265) [doi]
AB  - PURPOSE: In this series of articles--Research Ethics I, Research Ethics II, and
      Research Ethics III--the authors provide a comprehensive review of the 9 core
      domains for the responsible conduct of research (RCR) as articulated by the
      Office of Research Integrity. In Research Ethics I, they present a historical
      overview of the evolution of RCR in the United States then examine the evolution 
      of human and animal experimentation from the birth of scientific medicine through
      World War II to the present day. METHOD: They relied on authoritative documents, 
      both historical and contemporary, insightful commentary, and empirical research
      in order to identify current issues and controversies of potential interest to
      both faculty and students. CONCLUSIONS: The authors have written this article
      from a historical perspective because they think all readers interested in RCR
      should appreciate how the history of science and all the good--and harm--it has
      produced can inform how researchers practice responsible research in the 21st
      century and beyond.
FAU - Horner, Jennifer
AU  - Horner J
AD  - College of Health Sciences and Professions, Ohio University, W380 Grover Center, 
      Athens, OH 45701, USA. hornerj@ohio.edu
FAU - Minifie, Fred D
AU  - Minifie FD
LA  - eng
GR  - NS44534/NS/NINDS NIH HHS/United States
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20101116
PL  - United States
TA  - J Speech Lang Hear Res
JT  - Journal of speech, language, and hearing research : JSLHR
JID - 9705610
SB  - IM
MH  - Animal Experimentation/ethics/*history
MH  - Animals
MH  - Biomedical Research/ethics/*history
MH  - Ethics, Medical/*history
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Human Experimentation/ethics/*history
MH  - Humans
MH  - United States
EDAT- 2010/11/18 06:00
MHDA- 2011/05/27 06:00
CRDT- 2010/11/18 06:00
PHST- 2010/11/18 06:00 [entrez]
PHST- 2010/11/18 06:00 [pubmed]
PHST- 2011/05/27 06:00 [medline]
AID - 1092-4388_2010_09-0265 [pii]
AID - 10.1044/1092-4388(2010/09-0265) [doi]
PST - ppublish
SO  - J Speech Lang Hear Res. 2011 Feb;54(1):S303-29. doi:
      10.1044/1092-4388(2010/09-0265). Epub 2010 Nov 16.


PMID- 21081676
OWN - NLM
STAT- MEDLINE
DCOM- 20110526
LR  - 20110202
IS  - 1558-9102 (Electronic)
IS  - 1092-4388 (Linking)
VI  - 54
IP  - 1
DP  - 2011 Feb
TI  - Ethical principles associated with the publication of research in ASHA's
      scholarly journals: importance and adequacy of coverage.
PG  - S394-416
LID - 10.1044/1092-4388(2010/09-0260) [doi]
AB  - PURPOSE: The purpose of this 2-part study was to determine the importance of
      specific topics relating to publication ethics and adequacy of the American
      Speech-Language-Hearing Association's (ASHA's) policies regarding these topics.
      METHOD: A 56-item Web-based survey was sent to (a) ASHA journal editors,
      associate editors, and members of the Publications Board (Group 1); (b) authors, 
      reviewers, and members of ASHA's Board of Ethics (Group 2); and (c) a random
      sample of the ASHA membership, characterized as journal readers (Group 3). The
      survey contained 4 questions related to ethical principles associated with the
      publication of research: (a) In regard to scientific integrity in research
      publications in general, how important is the issue of [topic]? (b) Should ASHA
      publication policies address this issue? (c) Do ASHA policies address this issue?
      (d) If yes, how adequately do ASHA policies address this issue? A second study
      evaluated the contents of ASHA's publication policy documents in regard to their 
      coverage of the survey topics. RESULTS: Results indicated many of the topics
      deemed most important by all groups were included in ASHA's publication policy
      documents; other topics, although included, were not adequately addressed.
      CONCLUSIONS: ASHA needs a single, unifying publication policy document, and
      increased education of all groups in the realm of ethics in the publication
      process is indicated.
FAU - Ingham, Janis C
AU  - Ingham JC
AD  - Department of Speech and Hearing Sciences, University of California, Santa
      Barbara, Santa Barbara, CA 93106, USA. jcingham@speech.ucsb.edu
FAU - Minifie, Fred D
AU  - Minifie FD
FAU - Horner, Jennifer
AU  - Horner J
FAU - Robey, Randall R
AU  - Robey RR
FAU - Lansing, Charissa
AU  - Lansing C
FAU - McCartney, James H
AU  - McCartney JH
FAU - Slater, Sarah C
AU  - Slater SC
FAU - Moss, Sharon E
AU  - Moss SE
LA  - eng
GR  - NS44534-01/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20101116
PL  - United States
TA  - J Speech Lang Hear Res
JT  - Journal of speech, language, and hearing research : JSLHR
JID - 9705610
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Data Collection
MH  - Editorial Policies
MH  - *Hearing Disorders
MH  - Humans
MH  - Internet
MH  - *Language Disorders
MH  - Peer Review, Research/*ethics
MH  - Periodicals as Topic/*ethics
MH  - Societies, Medical
EDAT- 2010/11/18 06:00
MHDA- 2011/05/27 06:00
CRDT- 2010/11/18 06:00
PHST- 2010/11/18 06:00 [entrez]
PHST- 2010/11/18 06:00 [pubmed]
PHST- 2011/05/27 06:00 [medline]
AID - 1092-4388_2010_09-0260 [pii]
AID - 10.1044/1092-4388(2010/09-0260) [doi]
PST - ppublish
SO  - J Speech Lang Hear Res. 2011 Feb;54(1):S394-416. doi:
      10.1044/1092-4388(2010/09-0260). Epub 2010 Nov 16.


PMID- 21081675
OWN - NLM
STAT- MEDLINE
DCOM- 20110526
LR  - 20110202
IS  - 1558-9102 (Electronic)
IS  - 1092-4388 (Linking)
VI  - 54
IP  - 1
DP  - 2011 Feb
TI  - Research ethics III: Publication practices and authorship, conflicts of interest,
      and research misconduct.
PG  - S346-62
LID - 10.1044/1092-4388(2010/09-0263) [doi]
AB  - PURPOSE: In this series of articles--Research Ethics I, Research Ethics II, and
      Research Ethics III--the authors provide a comprehensive review of the 9 core
      domains for the responsible conduct of research (RCR) as articulated by the
      Office of Research Integrity. METHOD: In Research Ethics III, they review the RCR
      domains of publication practices and authorship, conflicts of interest, and
      research misconduct. Whereas the legal definition of research misconduct under
      federal law pertains mainly to intentional falsification, fabrication, and
      plagiarism, they discuss a host of research practices that raise ethical
      concerns. CONCLUSIONS: The integrity of the scientific record--its accuracy,
      completeness, and value--ultimately impacts the health and well-being of society.
      For this reason, scientists are both entrusted and obligated to use the highest
      standards possible when proposing, performing, reviewing, and reporting research 
      or when educating and mentoring new investigators.
FAU - Horner, Jennifer
AU  - Horner J
AD  - College of Health Sciences and Professions, Ohio University, W380 Grover Center, 
      Athens, OH 45701, USA. hornerj@ohio.edu
FAU - Minifie, Fred D
AU  - Minifie FD
LA  - eng
GR  - NS44534/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20101116
PL  - United States
TA  - J Speech Lang Hear Res
JT  - Journal of speech, language, and hearing research : JSLHR
JID - 9705610
SB  - IM
MH  - Animals
MH  - *Authorship
MH  - Biomedical Research/*ethics
MH  - *Conflict of Interest
MH  - Humans
MH  - Publications/*ethics
MH  - Scientific Misconduct/*ethics
EDAT- 2010/11/18 06:00
MHDA- 2011/05/27 06:00
CRDT- 2010/11/18 06:00
PHST- 2010/11/18 06:00 [entrez]
PHST- 2010/11/18 06:00 [pubmed]
PHST- 2011/05/27 06:00 [medline]
AID - 1092-4388_2010_09-0263 [pii]
AID - 10.1044/1092-4388(2010/09-0263) [doi]
PST - ppublish
SO  - J Speech Lang Hear Res. 2011 Feb;54(1):S346-62. doi:
      10.1044/1092-4388(2010/09-0263). Epub 2010 Nov 16.


PMID- 21081600
OWN - NLM
STAT- MEDLINE
DCOM- 20101130
LR  - 20211020
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 341
DP  - 2010 Nov 16
TI  - Effect on peer review of telling reviewers that their signed reviews might be
      posted on the web: randomised controlled trial.
PG  - c5729
LID - 10.1136/bmj.c5729 [doi]
LID - bmj.c5729 [pii]
AB  - OBJECTIVES: To see whether telling peer reviewers that their signed reviews of
      original research papers might be posted on the BMJ's website would affect the
      quality of their reviews. DESIGN: Randomised controlled trial. SETTING: A large
      international general medical journal based in the United Kingdom. PARTICIPANTS: 
      541 authors, 471 peer reviewers, and 12 editors. INTERVENTION: Consecutive
      eligible papers were randomised either to have the reviewer's signed report made 
      available on the BMJ's website alongside the published paper (intervention group)
      or to have the report made available only to the author-the BMJ's normal
      procedure (control group). The intervention was the act of revealing to
      reviewers-after they had agreed to review but before they undertook their
      review-that their signed report might appear on the website. MAIN OUTCOME
      MEASURES: The main outcome measure was the quality of the reviews, as
      independently rated on a scale of 1 to 5 using a validated instrument by two
      editors and the corresponding author. Authors and editors were blind to the
      intervention group. Authors rated review quality before the fate of their paper
      had been decided. Additional outcomes were the time taken to complete the review 
      and the reviewer's recommendation regarding publication. RESULTS: 558 manuscripts
      were randomised, and 471 manuscripts remained after exclusions. Of the 1039
      reviewers approached to take part in the study, 568 (55%) declined. Two editors' 
      evaluations of the quality of the peer review were obtained for all 471
      manuscripts, with the corresponding author's evaluation obtained for 453. There
      was no significant difference in review quality between the intervention and
      control groups (mean difference for editors 0.04, 95% CI -0.09 to 0.17; for
      authors 0.06, 95% CI -0.09 to 0.20). Any possible difference in favour of the
      control group was well below the level regarded as editorially significant.
      Reviewers in the intervention group took significantly longer to review (mean
      difference 25 minutes, 95% CI 3.0 to 47.0 minutes). CONCLUSION: Telling peer
      reviewers that their signed reviews might be available in the public domain on
      the BMJ's website had no important effect on review quality. Although the
      possibility of posting reviews online was associated with a high refusal rate
      among potential peer reviewers and an increase in the amount of time taken to
      write a review, we believe that the ethical arguments in favour of open peer
      review more than outweigh these disadvantages.
FAU - van Rooyen, Susan
AU  - van Rooyen S
AD  - BMJ, BMA House, London, UK.
FAU - Delamothe, Tony
AU  - Delamothe T
FAU - Evans, Stephen J W
AU  - Evans SJ
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20101116
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
SB  - IM
MH  - Authorship
MH  - Disclosure
MH  - *Internet
MH  - *Manuscripts, Medical as Topic
MH  - *Peer Review, Research
MH  - *Periodicals as Topic
MH  - Time Factors
PMC - PMC2982798
EDAT- 2010/11/18 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/11/18 06:00
PHST- 2010/11/18 06:00 [entrez]
PHST- 2010/11/18 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1136/bmj.c5729 [doi]
PST - epublish
SO  - BMJ. 2010 Nov 16;341:c5729. doi: 10.1136/bmj.c5729.


PMID- 21081019
OWN - NLM
STAT- MEDLINE
DCOM- 20160423
LR  - 20181201
IS  - 0256-9574 (Print)
VI  - 100
IP  - 11
DP  - 2010 Nov 9
TI  - Protection of human participants in health research - a comparison of some US
      Federal Regulations and South African Research Ethics guidelines.
PG  - 712-6
AB  - In response to criticism of ethical review of a South African clinical trial, we 
      contrast aspects of the United States Common Rule with South African research
      ethics requirements. In the USA the Common Rule does not apply to all health
      research and allows many exemptions from ethics review and waivers of informed
      consent. At a structural level research ethics review in South Africa is in many 
      cases equivalent to the US institutional review board (IRB) and Office for Human 
      Research Protections (OHRP) oversight system, is wider reaching, and has no
      exclusions.
FAU - Cleaton-Jones, P
AU  - Cleaton-Jones P
AD  - Steve Biko Centre for Bioethics. pcleatonjones@gmal.com.
FAU - Wassenaar, D
AU  - Wassenaar D
LA  - eng
PT  - Journal Article
DEP - 20101109
PL  - South Africa
TA  - S Afr Med J
JT  - South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
JID - 0404520
SB  - IM
MH  - Ethical Review
MH  - *Ethics Committees, Research
MH  - *Ethics, Research
MH  - Humans
MH  - Informed Consent/legislation & jurisprudence
MH  - Research
MH  - United States
EDAT- 2010/11/18 06:00
MHDA- 2016/04/24 06:00
CRDT- 2010/11/18 06:00
PHST- 2010/09/13 00:00 [received]
PHST- 2010/09/20 00:00 [accepted]
PHST- 2010/11/18 06:00 [entrez]
PHST- 2010/11/18 06:00 [pubmed]
PHST- 2016/04/24 06:00 [medline]
PST - epublish
SO  - S Afr Med J. 2010 Nov 9;100(11):712-6.


PMID- 21081016
OWN - NLM
STAT- MEDLINE
DCOM- 20160423
LR  - 20191027
IS  - 0256-9574 (Print)
VI  - 100
IP  - 11
DP  - 2010 Nov 9
TI  - Ethical challenges in an age of overpopulation.
PG  - 694
FAU - Jargin, Sergei V
AU  - Jargin SV
AD  - Peoples' Friendship University of Russia. sjargin2000@yahoo.com.
LA  - eng
PT  - Journal Article
DEP - 20101109
PL  - South Africa
TA  - S Afr Med J
JT  - South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
JID - 0404520
SB  - IM
MH  - *Ethics, Medical
MH  - Humans
MH  - Morals
MH  - *Population Density
EDAT- 2010/11/18 06:00
MHDA- 2016/04/24 06:00
CRDT- 2010/11/18 06:00
PHST- 2010/08/15 00:00 [received]
PHST- 2010/08/23 00:00 [accepted]
PHST- 2010/11/18 06:00 [entrez]
PHST- 2010/11/18 06:00 [pubmed]
PHST- 2016/04/24 06:00 [medline]
AID - 10.7196/samj.4458 [doi]
PST - epublish
SO  - S Afr Med J. 2010 Nov 9;100(11):694. doi: 10.7196/samj.4458.


PMID- 21081000
OWN - NLM
STAT- MEDLINE
DCOM- 20110103
LR  - 20191027
IS  - 0256-9574 (Print)
VI  - 100
IP  - 10
DP  - 2010 Oct 1
TI  - Shallow-water spinal injuries--devastating but preventable.
PG  - 682-4
AB  - BACKGROUND: Shallow-water diving injuries have devastating consequences for
      patients and their families, requiring intensive use of resources in both the
      acute and rehabilitative phases of injury. With the final clinical outcome often 
      poor, the question is raised as to whether a target group can be identified for
      whom to implement a preventive programme. OBJECTIVE: To evaluate the
      demographics, clinical features and outcomes of shallow-water diving injuries in 
      an acute spinal cord injury (ASCI) unit. MATERIALS AND METHODS: All patients
      admitted to the ASCI unit with diving-related injuries were entered into the
      study. Data regarding demographics, injury profile and subsequent management were
      collated. All case notes and X-rays were reviewed. Ethical approval was obtained.
      RESULTS: Forty-six patients were reviewed from 19 April 2003 to 8 February 2009. 
      A steady annual increase in diving injuries was noted. A very specific patient
      profile was identified: 91% male incidence, average age 23 years, 37% admitted
      alcohol use, with a summer-time prevalence. Compression-flexion type injuries
      were most prevalent, with an orthopaedic level of C5 and neurological level of C4
      being the most common injury sites. A third of diving injuries occurred in the
      sea, 20% in swimming pools, 20% in rivers, 11% in tidal pools and 4% in dams.
      CONCLUSION: A very specific patient profile was identified, and the severity of
      shallow-water diving injuries was confirmed. No current preventive programme
      exists except for a single television advertisement. These data will be used to
      motivate further educational and preventive programmes for reducing the incidence
      of diving-related injuries.
FAU - Vlok, A J
AU  - Vlok AJ
AD  - Groote Schuur Hospital. ianvlok@gmail.com
FAU - Petersen, J
AU  - Petersen J
FAU - Dunn, R N
AU  - Dunn RN
FAU - Stander, J
AU  - Stander J
LA  - eng
PT  - Journal Article
DEP - 20101001
PL  - South Africa
TA  - S Afr Med J
JT  - South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
JID - 0404520
SB  - IM
MH  - Alcohol Drinking
MH  - Cervical Vertebrae/injuries
MH  - Diving/*injuries
MH  - Female
MH  - Health Education
MH  - Humans
MH  - Male
MH  - Seasons
MH  - South Africa/epidemiology
MH  - Spinal Injuries/epidemiology/*etiology/*prevention & control
MH  - Television
MH  - Young Adult
EDAT- 2010/11/18 06:00
MHDA- 2011/01/05 06:00
CRDT- 2010/11/18 06:00
PHST- 2009/08/09 00:00 [received]
PHST- 2009/12/10 00:00 [accepted]
PHST- 2010/11/18 06:00 [entrez]
PHST- 2010/11/18 06:00 [pubmed]
PHST- 2011/01/05 06:00 [medline]
AID - 10.7196/samj.3712 [doi]
PST - epublish
SO  - S Afr Med J. 2010 Oct 1;100(10):682-4. doi: 10.7196/samj.3712.


PMID- 21080926
OWN - NLM
STAT- MEDLINE
DCOM- 20110322
LR  - 20211020
IS  - 1471-2458 (Electronic)
IS  - 1471-2458 (Linking)
VI  - 10
DP  - 2010 Nov 16
TI  - To what extent could performance-based schemes help increase the effectiveness of
      prevention of mother-to-child transmission of HIV (PMTCT) programs in
      resource-limited settings? A summary of the published evidence.
PG  - 702
LID - 10.1186/1471-2458-10-702 [doi]
AB  - BACKGROUND: In resource-limited settings, HIV/AIDS remains a serious threat to
      the social and physical well-being of women of childbearing age, pregnant women, 
      mothers and infants. DISCUSSION: In sub-Saharan African countries with high
      prevalence rates, pediatric HIV/AIDS acquired through mother-to-child
      transmission (MTCT) can in largely be prevented by using well-established
      biomedical interventions. Logistical and socio-cultural barriers continue,
      however, to undermine the successful prevention of MTCT (PMTCT). In this paper,
      we review reports on maternal, neonatal and child health, as well as HIV care and
      treatment services that look at program incentives. SUMMARY: These studies
      suggest that comprehensive PMTCT strategies aiming to maximize health-worker
      motivation in developing countries must involve a mix of both financial and
      non-financial incentives. The establishment of robust ethical and regulatory
      standards in public-sector HIV care centers could reduce barriers to PMTCT
      service provision in sub-Saharan Africa and help them in achieving universal
      PMTCT targets.
FAU - Toure, Hapsatou
AU  - Toure H
AD  - INSERM U897, Institut de Sante Publique d'Epidemiologie et de Developpement
      (ISPED), Universite Victor Segalen, 146 Rue Leo Saignat, 33000, Bordeaux, France.
      hapsatou.toure@isped.u-bordeaux2.fr
FAU - Audibert, Martine
AU  - Audibert M
FAU - Dabis, Francois
AU  - Dabis F
LA  - eng
PT  - Journal Article
DEP - 20101116
PL  - England
TA  - BMC Public Health
JT  - BMC public health
JID - 100968562
SB  - IM
MH  - Africa South of the Sahara
MH  - Evidence-Based Practice
MH  - Female
MH  - HIV Infections/*prevention & control/*transmission
MH  - Health Resources/*supply & distribution
MH  - Humans
MH  - Infectious Disease Transmission, Vertical/*prevention & control
MH  - Pregnancy
MH  - Quality Assurance, Health Care/*standards
PMC - PMC3000852
EDAT- 2010/11/18 06:00
MHDA- 2011/03/23 06:00
CRDT- 2010/11/18 06:00
PHST- 2010/01/18 00:00 [received]
PHST- 2010/11/16 00:00 [accepted]
PHST- 2010/11/18 06:00 [entrez]
PHST- 2010/11/18 06:00 [pubmed]
PHST- 2011/03/23 06:00 [medline]
AID - 1471-2458-10-702 [pii]
AID - 10.1186/1471-2458-10-702 [doi]
PST - epublish
SO  - BMC Public Health. 2010 Nov 16;10:702. doi: 10.1186/1471-2458-10-702.


PMID- 21079899
OWN - NLM
STAT- MEDLINE
DCOM- 20110330
LR  - 20191111
IS  - 1809-4546 (Electronic)
IS  - 0100-6991 (Linking)
VI  - 37
IP  - 3
DP  - 2010 Jun
TI  - [Clinical bioethics: how to practice?].
PG  - 245-6
LID - S0100-69912010000300014 [pii]
AB  - To think about ethics means to go into the Bioethics universe. If it is
      understood that medical ethics deals with doctors within an organized society
      under legal purposes, consensus and ethics in the exercise of medicine it is
      observed that Bioethics came up due to the need to debate and decide on the ethic
      questions related mainly to research and scientific advances as well as conquests
      concerning human rights and social-cultural development: it is the critical
      expression of our interest in conveniently using the development of medical art
      and science. Within Medicine, clinical Bioethics arouse as a possibility of
      thinking and discussing the practice of medicine in the different social
      institutions which deal with health and with professionals in health area.
FAU - de Oliveira, Reinaldo Ayer
AU  - de Oliveira RA
AD  - Departamento de Medicina Legal, Etica Medica, Medicina Social e do Trabalho,
      Faculdade de Medicina, Universidade de Sao Paulo.
FAU - Jorge Filho, Isac
AU  - Jorge Filho I
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Bioetica clinica: como pratica-la?
PL  - Brazil
TA  - Rev Col Bras Cir
JT  - Revista do Colegio Brasileiro de Cirurgioes
JID - 7809515
SB  - IM
MH  - *Ethics, Clinical
EDAT- 2010/11/17 06:00
MHDA- 2011/03/31 06:00
CRDT- 2010/11/17 06:00
PHST- 2010/02/08 00:00 [received]
PHST- 2010/03/15 00:00 [accepted]
PHST- 2010/11/17 06:00 [entrez]
PHST- 2010/11/17 06:00 [pubmed]
PHST- 2011/03/31 06:00 [medline]
AID - S0100-69912010000300014 [pii]
AID - 10.1590/s0100-69912010000300014 [doi]
PST - ppublish
SO  - Rev Col Bras Cir. 2010 Jun;37(3):245-6. doi: 10.1590/s0100-69912010000300014.


PMID- 21079436
OWN - NLM
STAT- MEDLINE
DCOM- 20110318
LR  - 20220410
IS  - 1536-3724 (Electronic)
IS  - 1050-642X (Linking)
VI  - 20
IP  - 6
DP  - 2010 Nov
TI  - The effect of kinesiotape on function, pain, and motoneuronal excitability in
      healthy people and people with Achilles tendinopathy.
PG  - 416-21
LID - 10.1097/JSM.0b013e3181f479b0 [doi]
AB  - OBJECTIVE: To investigate the effect of kinesiotape on hop distance, pain, and
      motoneuronal excitability in healthy people and people with Achilles tendinopathy
      (AT). DESIGN: Within-subject design. SETTING: An academic health science center, 
      which is an acute London National Health Service trust. PARTICIPANTS: With
      ethical approval and informed consent, a convenience sample of 26 healthy people 
      and 29 people with AT were recruited. Seven participants were lost after
      functional testing, leaving 24 participants in each group. INTERVENTIONS:
      Kinesiotape applied over the Achilles tendon. MAIN OUTCOME MEASURES: The
      single-leg hop test and visual analog scale were measured with and without the
      tape. Using the Hoffman (H) reflex, change in motoneuronal excitability of calf
      muscles was measured before tape application, with the tape on and after its
      removal. RESULTS: There were no changes to hop distance when tape was applied (P 
      = 0.55). Additionally, there were no changes to pain (P = 0.74). The H reflex
      amplitude of soleus and gastrocnemius increased in the healthy group after its
      removal (P = 0.01 and P = 0.03, respectively), whereas the H reflex remained
      unchanged in people with AT (P = 0.43 and 0.16, respectively). CONCLUSIONS: Calf 
      muscles were facilitated by kinesiotape in healthy participants. Despite this,
      there was no change to hop distance. Kinesiotape had no effect on hop distance,
      pain, or motoneuronal excitability in people with AT. These results do not
      support the use of kinesiotape applied in this way for this condition.
FAU - Firth, Bridget L
AU  - Firth BL
AD  - Department of Physiotherapy, Charing Cross Hospital, Imperial College Healthcare 
      NHS Trust, London, England, UK.
FAU - Dingley, Paul
AU  - Dingley P
FAU - Davies, Elizabeth R
AU  - Davies ER
FAU - Lewis, Jeremy S
AU  - Lewis JS
FAU - Alexander, Caroline M
AU  - Alexander CM
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Clin J Sport Med
JT  - Clinical journal of sport medicine : official journal of the Canadian Academy of 
      Sport Medicine
JID - 9103300
SB  - IM
MH  - Achilles Tendon/*physiopathology
MH  - Adult
MH  - Aged
MH  - *Athletic Tape
MH  - Female
MH  - *Health
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Motor Neurons/*physiology
MH  - Muscle Strength/physiology
MH  - Muscle, Skeletal/physiopathology
MH  - *Pain Management
MH  - Pain Measurement
MH  - Reflex, Abnormal/physiology
MH  - Tendinopathy/*therapy
MH  - Young Adult
EDAT- 2010/11/17 06:00
MHDA- 2011/03/19 06:00
CRDT- 2010/11/17 06:00
PHST- 2010/11/17 06:00 [entrez]
PHST- 2010/11/17 06:00 [pubmed]
PHST- 2011/03/19 06:00 [medline]
AID - 10.1097/JSM.0b013e3181f479b0 [doi]
AID - 00042752-201011000-00006 [pii]
PST - ppublish
SO  - Clin J Sport Med. 2010 Nov;20(6):416-21. doi: 10.1097/JSM.0b013e3181f479b0.


PMID- 21079377
OWN - NLM
STAT- MEDLINE
DCOM- 20101210
LR  - 20190608
IS  - 0916-8818 (Print)
IS  - 0916-8818 (Linking)
VI  - 56
IP  - 5
DP  - 2010 Oct
TI  - Derivation of histocompatible stem cells from ovarian tissue.
PG  - 481-94
AB  - Somatic cell nuclear transfer, the first established technique for producing
      patient-specific autologous stem cells, inevitably requires the sacrifice of
      viable embryos. To circumvent the serious ethical issues associated with this use
      of embryos, researchers have developed several alternative methods for the
      production of histocompatible stem cells. In our research, we have used two
      methods to derive histocompatible stem cells from murine ovarian tissue. First,
      we have established autologous stem cells by culturing degeneration-fated
      preantral follicles to produce developmentally competent, mature oocytes and then
      parthenogenetically activating these mature oocytes to acquire genetic
      homogeneity. Second, we have used cell-to-cell interactions to derive stem cells 
      from ovarian stromal cells without undertaking genetic modification. We have
      successfully derived autologous murine stem cells by manipulating primary and
      early secondary follicles in vitro, and this method has proved successful even
      for follicles retrieved from aged ovaries. Furthermore, we believe that it will
      be possible to isolate stem cells directly from non-germline ovarian tissue or to
      derive stem cells by culturing the ovarian cells with other somatic cells. If
      achieved, these aims will greatly advance the development of induced pluripotent 
      stem cell technology, as well as tissue-specific stem cell research. In this
      review, we introduce the relevant technologies for establishing histocompatible
      stem cells from ovarian tissue cells without undertaking genetic manipulation and
      review the current limitations of, and future research directions in, stem cell
      biology.
FAU - GONG, Seung Pyo
AU  - GONG SP
AD  - WCU Biomodulation Program, Seoul National University, Seoul, South Korea.
FAU - LEE, Jae Hee
AU  - LEE JH
FAU - LIM, Jeong Mook
AU  - LIM JM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Japan
TA  - J Reprod Dev
JT  - The Journal of reproduction and development
JID - 9438792
SB  - IM
MH  - Adult Stem Cells/*cytology
MH  - Animals
MH  - Female
MH  - Histocompatibility
MH  - Humans
MH  - Mice
MH  - *Nuclear Transfer Techniques
MH  - Ovarian Follicle/*cytology
MH  - *Parthenogenesis
MH  - Stromal Cells/*cytology
EDAT- 2010/11/17 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/11/17 06:00
PHST- 2010/11/17 06:00 [entrez]
PHST- 2010/11/17 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - JST.JSTAGE/jrd/10-043E [pii]
AID - 10.1262/jrd.10-043e [doi]
PST - ppublish
SO  - J Reprod Dev. 2010 Oct;56(5):481-94. doi: 10.1262/jrd.10-043e.


PMID- 21079319
OWN - NLM
STAT- MEDLINE
DCOM- 20111013
LR  - 20181201
IS  - 0973-3922 (Electronic)
IS  - 0378-6323 (Linking)
VI  - 76
IP  - 6
DP  - 2010 Nov-Dec
TI  - Cosmeceutical testing: ethical and scientific issues.
PG  - 701
LID - 10.4103/0378-6323.72444 [doi]
FAU - Singh, Gurcharan
AU  - Singh G
FAU - Prakash, Bhanu
AU  - Prakash B
LA  - eng
PT  - Letter
PT  - Comment
PL  - United States
TA  - Indian J Dermatol Venereol Leprol
JT  - Indian journal of dermatology, venereology and leprology
JID - 7701852
RN  - 0 (Prodrugs)
RN  - 1406-18-4 (Vitamin E)
RN  - 19F5HK2737 (Pantothenic Acid)
RN  - 25X51I8RD4 (Niacinamide)
SB  - IM
CON - Indian J Dermatol Venereol Leprol. 2010 Jan-Feb;76(1):20-6. PMID: 20061726
MH  - *Face
MH  - Female
MH  - Humans
MH  - Hyperpigmentation/*drug therapy
MH  - Niacinamide/*administration & dosage
MH  - Pantothenic Acid/*administration & dosage
MH  - Prodrugs/*administration & dosage
MH  - Vitamin E/*administration & dosage
EDAT- 2010/11/17 06:00
MHDA- 2011/10/14 06:00
CRDT- 2010/11/17 06:00
PHST- 2010/11/17 06:00 [entrez]
PHST- 2010/11/17 06:00 [pubmed]
PHST- 2011/10/14 06:00 [medline]
AID - ijdvl_2010_76_6_701_72444 [pii]
AID - 10.4103/0378-6323.72444 [doi]
PST - ppublish
SO  - Indian J Dermatol Venereol Leprol. 2010 Nov-Dec;76(6):701. doi:
      10.4103/0378-6323.72444.


PMID- 21079221
OWN - NLM
STAT- MEDLINE
DCOM- 20101207
LR  - 20211020
IS  - 1539-3704 (Electronic)
IS  - 0003-4819 (Linking)
VI  - 153
IP  - 10
DP  - 2010 Nov 16
TI  - Streamlining ethical review.
PG  - 655-7
LID - 10.7326/0003-4819-153-10-201011160-00008 [doi]
AB  - The review system for human subjects research in the United States has been
      widely criticized in recent years for requirements that delay research without
      improving human subject protections. Any major reformulation of regulations may
      take some time to implement. However, current regulations often allow for
      streamlined ethics review that does not jeopardize-and may improve-protections
      for research participants. The authors discuss underutilized options, including
      research that need not be classified as human subjects research, categories of
      studies that can be exempt from ethical review, studies that need only undergo
      expedited review by 1 institutional review board (IRB) member, and simplifying
      reviews of multicenter research by using the IRB of 1 institution. The authors
      speculate on multiple reasons for the underuse of these mechanisms and exhort
      IRBs and researchers to take advantage of these important opportunities to
      improve the review process.
FAU - Millum, Joseph
AU  - Millum J
AD  - Clinical Center Department of Bioethics and Fogarty International Center,
      National Institutes of Health, Bethesda, MD 20892-1156, USA. millumj@cc.nih.gov
FAU - Menikoff, Jerry
AU  - Menikoff J
LA  - eng
GR  - Z99 CL999999/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Ann Intern Med
JT  - Annals of internal medicine
JID - 0372351
SB  - IM
MH  - *Ethical Review/classification
MH  - Ethics Committees, Research
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Multicenter Studies as Topic/ethics
PMC - PMC4714763
MID - NIHMS740545
EDAT- 2010/11/17 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/11/17 06:00
PHST- 2010/11/17 06:00 [entrez]
PHST- 2010/11/17 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 153/10/655 [pii]
AID - 10.7326/0003-4819-153-10-201011160-00008 [doi]
PST - ppublish
SO  - Ann Intern Med. 2010 Nov 16;153(10):655-7. doi:
      10.7326/0003-4819-153-10-201011160-00008.


PMID- 21079201
OWN - NLM
STAT- MEDLINE
DCOM- 20110317
LR  - 20110128
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 258
IP  - 2
DP  - 2011 Feb
TI  - T1-weighted fat-suppressed imaging of the pelvis with a dual-echo Dixon
      technique: initial clinical experience.
PG  - 583-9
LID - 10.1148/radiol.10100912 [doi]
AB  - PURPOSE: To compare the image quality of water-only images generated from a
      dual-echo Dixon technique with that of standard fast spin-echo T1-weighted
      chemical shift fat-suppressed images obtained in patients evaluated for pelvic
      pain with a 1.5-T magnetic resonance (MR) system. MATERIALS AND METHODS: The
      ethics board granted approval for this retrospective study; patient consent was
      not required. Twenty-five women underwent both standard axial T1-weighted fast
      spin-echo chemical shift fat-suppressed imaging and dual-echo Dixon imaging of
      the pelvis. Two readers independently scored the acquisitions for image quality, 
      fat suppression quality, and artifact. On the basis of signal intensity
      measurements, the uniformity of fat suppression, the contrast between
      fat-suppressed and non-fat-suppressed tissue, and the contrast between pathologic
      lesions and suppressed fat were calculated. Values obtained with the T1-weighted 
      fat-suppressed and dual-echo Dixon techniques were compared by using the Wilcoxon
      signed rank test. RESULTS: The images generated with the dual-echo Dixon
      technique were of higher quality, had better fat suppression, and had less
      artifact (qualitative scores: 4.4, 4.6, and 4.0, respectively) compared with the 
      standard T1-weighted fat-suppressed images (qualitative scores: 3.4, 3.3, and
      3.6, respectively; P < .01). Contrast between fat-suppressed and
      non-fat-suppressed tissue (contrast ratio: 0.86 for dual-echo Dixon technique vs 
      0.42 for T1-weighted fat-suppressed technique, P < .001) and between pathologic
      lesions and suppressed fat (contrast ratio: 0.88 for dual-echo Dixon technique vs
      0.57 for T1-weighted fat-suppressed technique, P =.012) was significantly
      improved with the dual-echo Dixon technique. Twelve pathologic lesions were
      identified with dual-echo Dixon imaging versus eight that were identified with
      T1-weighted fat-suppressed imaging. CONCLUSION: Compared with standard
      T1-weighted fat-suppressed imaging, dual-echo Dixon imaging facilitates improved 
      image quality of fat-suppressed images of the pelvis, enabling better delineation
      of pathologic lesions.
CI  - (c) RSNA, 2010.
FAU - Beddy, Peter
AU  - Beddy P
AD  - Department of Radiology, University of Cambridge, Addenbrooke's Hospital, Hills
      Road, Cambridge, England CB2 0QQ. pbeddy@eircom.net
FAU - Rangarajan, R Deepa
AU  - Rangarajan RD
FAU - Kataoka, Masako
AU  - Kataoka M
FAU - Moyle, Penelope
AU  - Moyle P
FAU - Graves, Martin J
AU  - Graves MJ
FAU - Sala, Evis
AU  - Sala E
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20101115
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adipose Tissue
MH  - Adult
MH  - Artifacts
MH  - Body Water
MH  - Female
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Imaging, Three-Dimensional
MH  - Magnetic Resonance Imaging/*methods
MH  - Middle Aged
MH  - Pelvic Pain/*diagnosis
MH  - Retrospective Studies
MH  - Statistics, Nonparametric
EDAT- 2010/11/17 06:00
MHDA- 2011/03/18 06:00
CRDT- 2010/11/17 06:00
PHST- 2010/11/17 06:00 [entrez]
PHST- 2010/11/17 06:00 [pubmed]
PHST- 2011/03/18 06:00 [medline]
AID - radiol.10100912 [pii]
AID - 10.1148/radiol.10100912 [doi]
PST - ppublish
SO  - Radiology. 2011 Feb;258(2):583-9. doi: 10.1148/radiol.10100912. Epub 2010 Nov 15.


PMID- 21077929
OWN - NLM
STAT- MEDLINE
DCOM- 20110502
LR  - 20151119
IS  - 1365-2648 (Electronic)
IS  - 0309-2402 (Linking)
VI  - 67
IP  - 1
DP  - 2011 Jan
TI  - Effects of a patient/family-centered practice change on the quality and cost of
      intensive care: research protocol.
PG  - 215-24
LID - 10.1111/j.1365-2648.2010.05448.x [doi]
AB  - AIM: This paper is a description of a protocol for studying the impact of a
      patient/family-centered, evidence-based practice change on the quality, cost and 
      use of services for critically ill patients at the end of life. BACKGROUND:
      International attention currently is focused on the quality and cost/use of
      intensive care services. Empirical literature and expert opinion suggest that
      early, enhanced communication among the clinical team and the patient and family 
      results in higher quality and less costly care at the end of life. DESIGN: Our
      Medical Intensive Care Unit practice change involves three components: teaching
      sessions for all Registered Nurses and physicians assigned to the unit;
      patient/family meetings held in 72 hours of the patient's admission to the unit; 
      and formal documentation to support communication among clinicians. Ethical
      approval was obtained in April 2009. A two-group post-test design is used, with
      one group comprising patients hospitalized before the practice change and their
      families, and the second group of patients/families after the practice change.
      Data comprise medical record information and families' responses to surveys.
      Final analytic models will result from multivariable regression techniques.
      DISCUSSION: The study represents translational research in that interventions are
      brought to the bedside to reach the people for whom the interventions were
      designed. The practice change is likely to endure after the study because our
      research team is composed of both clinicians and scientists. Also, direct care
      clinicians endorse and are responsible for the practice change.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Radwin, Laurel E
AU  - Radwin LE
AD  - University of Massachusetts Boston, Chelmsford, Massachusetts, USA.
      ler627@gmail.com
FAU - Ananian, Lillian
AU  - Ananian L
FAU - Cabral, Howard J
AU  - Cabral HJ
FAU - Keeley, Adele
AU  - Keeley A
FAU - Currier, Paul F
AU  - Currier PF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101116
PL  - England
TA  - J Adv Nurs
JT  - Journal of advanced nursing
JID - 7609811
SB  - IM
MH  - Adult
MH  - Aged, 80 and over
MH  - Attitude to Health
MH  - Clinical Nursing Research
MH  - Clinical Protocols
MH  - Communication
MH  - Critical Care/economics/*organization & administration/standards
MH  - Education, Continuing/organization & administration
MH  - *Evidence-Based Medicine
MH  - Family
MH  - Health Care Costs
MH  - Humans
MH  - Length of Stay
MH  - Medical Records
MH  - Patient-Centered Care/economics/*organization & administration/standards
MH  - *Professional-Family Relations
MH  - Quality Assurance, Health Care
MH  - *Research Design
MH  - Terminal Care/economics/organization & administration/standards
MH  - Young Adult
EDAT- 2010/11/17 06:00
MHDA- 2011/05/03 06:00
CRDT- 2010/11/17 06:00
PHST- 2010/11/17 06:00 [entrez]
PHST- 2010/11/17 06:00 [pubmed]
PHST- 2011/05/03 06:00 [medline]
AID - 10.1111/j.1365-2648.2010.05448.x [doi]
PST - ppublish
SO  - J Adv Nurs. 2011 Jan;67(1):215-24. doi: 10.1111/j.1365-2648.2010.05448.x. Epub
      2010 Nov 16.


PMID- 21077577
OWN - NLM
STAT- MEDLINE
DCOM- 20110103
LR  - 20181201
IS  - 1592-7830 (Print)
IS  - 1592-7830 (Linking)
VI  - 32
IP  - 4
DP  - 2010 Oct-Dec
TI  - The ethical challenges of the occupational physician in our time.
PG  - 403-6
AB  - An increasing interest in professional ethics is observed among occupational
      health professionals. To this may contribute the ongoing financial crisis of
      world economy. The moral development, induced i.a. by the Nuremberg trials in
      1947 has probably contributed to a changing moral landscape. Within health
      professions, including many categories of occupational health professionals there
      is an increasing awareness of the needs to revisit points of departure in
      building up ethical competence to and prepare their members for tasks in the
      Labour market. Selected topics will be commented on in respect to their
      challenges to occupational professional health ethics. Widening of perspectives
      of Ethics in traditional Hippocratic medical ethics issues related to
      requirements of confidentiality and informed consent.
FAU - Westerholm, P
AU  - Westerholm P
AD  - Uppsala University, Department of Occupational and Environmental Medicine,
      Ullerakersvagen 38-40, SE-751 85 Uppsala, Sweden.
LA  - eng
PT  - Lecture
PL  - Italy
TA  - G Ital Med Lav Ergon
JT  - Giornale italiano di medicina del lavoro ed ergonomia
JID - 9712708
SB  - IM
MH  - Bioethical Issues
MH  - Humans
MH  - Informed Consent
MH  - Occupational Medicine/*ethics
EDAT- 2010/11/17 06:00
MHDA- 2011/01/05 06:00
CRDT- 2010/11/17 06:00
PHST- 2010/11/17 06:00 [entrez]
PHST- 2010/11/17 06:00 [pubmed]
PHST- 2011/01/05 06:00 [medline]
PST - ppublish
SO  - G Ital Med Lav Ergon. 2010 Oct-Dec;32(4):403-6.


PMID- 21077379
OWN - NLM
STAT- MEDLINE
DCOM- 20101130
LR  - 20201209
IS  - 0040-7453 (Print)
IS  - 0040-7453 (Linking)
VI  - 135
IP  - 19
DP  - 2010 Oct 1
TI  - [Ethics in practice].
PG  - 721
FAU - van Luijk-Grevelink, Annemieke
AU  - van Luijk-Grevelink A
LA  - dut
PT  - Letter
TT  - Ethiek in de praktijk.
PL  - Netherlands
TA  - Tijdschr Diergeneeskd
JT  - Tijdschrift voor diergeneeskunde
JID - 0031550
SB  - IM
MH  - *Animal Welfare
MH  - Animals
MH  - *Human-Animal Bond
MH  - Humans
MH  - Veterinary Medicine/*ethics
EDAT- 2010/11/17 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/11/17 06:00
PHST- 2010/11/17 06:00 [entrez]
PHST- 2010/11/17 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - Tijdschr Diergeneeskd. 2010 Oct 1;135(19):721.


PMID- 20516770
OWN - NLM
STAT- MEDLINE
DCOM- 20110114
LR  - 20191210
IS  - 1648-9144 (Electronic)
IS  - 1010-660X (Linking)
VI  - 46 Suppl 1
DP  - 2010
TI  - [The importance of outcome indicators for pain control and their relationship to 
      nursing actions].
PG  - 54-62
AB  - UNLABELLED: Pain control is an aspect of patient care directly related to nursing
      competency and actions. Effective pain control, objectively evaluated according
      to nursing outcomes, is evidence of humane and high-quality care. The value of
      nursing outcome assessment increases when important and nursing-related outcome
      indicators are applied. The aim of this study was to analyze nursing outcomes and
      their indicators for pain control, investigating the importance and relationship 
      of indicators to nursing actions in nursing and supportive treatment. Content
      validity and nursing sensitivity of pain control nursing outcomes were
      additionally measured. MATERIAL AND METHODS: The study was performed in 13
      nursing and supportive treatment hospitals; 128 nurses were enrolled. The
      response rate was 63.3%. Three nursing outcomes of pain control were analyzed:
      Pain: Adverse Psychological Response, Pain: Disruptive Effects, and Pain Level. A
      list of 53 indicators for pain control outcomes was made from the Nursing
      Outcomes Classification, 2004. Cronbach alfa was estimated for each class of
      indicators. Importance of indicators and their relationship with nursing actions 
      were measured using the Likert scale. Content validity and nursing sensitivity
      were estimated with a modified Fehring technique (Fehring, 1987). For ethical
      considerations, approval of the National Committee on Bioethics was obtained. The
      Center for Nursing Classification and Clinical Effectiveness in the University of
      Iowa (USA) provided permission to use the 3rd edition of the NOC Use survey.
      RESULTS: The importance of each indicator of pain control nursing outcome was
      significant, i.e., >/=0.6. Out of the 53 studied indicators, 38 (71.7%) were
      strongly related to nursing action, and the remaining indicators were moderately 
      related. There was a strong positive correlation (Pearson r=0.835; P=0.000)
      between the content validity and nursing sensitivity of pain control nursing
      outcomes. CONCLUSIONS: The study revealed the three most important indicators for
      pain control nursing outcome assessment that are directly related to nursing
      competency and actions in nursing and supportive treatment.
FAU - Riklikiene, Olga
AU  - Riklikiene O
AD  - Department of Nursing and Care, Kaunas University of Medicine, Eiveniu 2, 50009
      Kaunas, Lithuania. rikolga@hotmail.com
FAU - Seskevicius, Arvydas
AU  - Seskevicius A
LA  - lit
PT  - Evaluation Study
PT  - Journal Article
TT  - Skausmo kontroles slaugos rezultatu kriteriju reiksmingumas ir sasajos su
      slaugytoju veikla.
PL  - Switzerland
TA  - Medicina (Kaunas)
JT  - Medicina (Kaunas, Lithuania)
JID - 9425208
SB  - IM
MH  - Clinical Competence
MH  - Data Interpretation, Statistical
MH  - Depression/etiology
MH  - Humans
MH  - Lithuania
MH  - *Outcome Assessment, Health Care
MH  - Pain/complications/*nursing/*prevention & control/psychology
MH  - *Quality Indicators, Health Care
MH  - *Quality of Health Care
MH  - Quality of Life
MH  - Statistics, Nonparametric
MH  - Surveys and Questionnaires
MH  - *Treatment Outcome
EDAT- 2010/11/17 06:00
MHDA- 2011/01/15 06:00
CRDT- 2010/06/03 06:00
PHST- 2010/06/03 06:00 [entrez]
PHST- 2010/11/17 06:00 [pubmed]
PHST- 2011/01/15 06:00 [medline]
AID - 10p1-07l [pii]
PST - ppublish
SO  - Medicina (Kaunas). 2010;46 Suppl 1:54-62.


PMID- 21076967
OWN - NLM
STAT- MEDLINE
DCOM- 20110729
LR  - 20211020
IS  - 1432-198X (Electronic)
IS  - 0931-041X (Linking)
VI  - 26
IP  - 5
DP  - 2011 May
TI  - Aciclovir and varicella-zoster-immunoglobulin in solid-organ transplant
      recipients.
PG  - 663-73
LID - 10.1007/s00467-010-1666-z [doi]
AB  - Clear recommendations for the management of acute varicella-zoster virus (VZV)
      infections for cases of significant exposure and the use of prophylactic drugs
      after solid-organ transplantation are missing due to the lack of evidence by
      prospective studies. Heterogeneity in patient groups, patient numbers, age
      groups, immunosuppressive regimens, timing, and dosage of aciclovir and/or
      varicella-zoster immunoglobulin (VZIG), pre-transplant vaccination or VZV
      wild-type infection and inconsistency of data make comparability of different
      studies impossible. Although the benefit of aciclovir and/or VZIG is uncertain in
      immunosuppressed children, prospective controlled double-blind studies are not
      feasible for ethical considerations as fatal cases with disseminating varicella
      disease are well known in these patient groups despite the use of aciclovir
      and/or VZIG, whereas severe side-effects of these drugs are rare. However, a
      reporting bias is likely as mainly severe or fatal cases might have been
      predominantly published or cases of successfully used aciclovir and/or VZIG in
      mild cases or in cases of breakthrough infections after vaccination. As neither
      VZIG prophylaxis nor treatment with intravenous aciclovir offers complete
      protection against severe VZV infection to immunosuppressed pediatric solid-organ
      transplant recipients, high priority should be given to vaccination against VZV
      prior to transplantation, and, most importantly, in their close contact persons. 
      Clinical observations suggest that only assessment of humoral immunity together
      with cellular immunity may allow predication about protection in exposed
      patients.
FAU - Prelog, Martina
AU  - Prelog M
AD  - Department of Pediatrics, Medical University Innsbruck, Innsbruck, Austria.
      Martina.Prelog@i-med.ac.at
FAU - Schonlaub, Jorn
AU  - Schonlaub J
FAU - Zimmerhackl, Lothar Bernd
AU  - Zimmerhackl LB
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20101115
PL  - Germany
TA  - Pediatr Nephrol
JT  - Pediatric nephrology (Berlin, Germany)
JID - 8708728
RN  - 0 (Antiviral Agents)
RN  - 0 (Immune Sera)
RN  - 0 (varicella-zoster immune globulin)
RN  - X4HES1O11F (Acyclovir)
SB  - IM
MH  - Acyclovir/*therapeutic use
MH  - Antiviral Agents/*therapeutic use
MH  - Herpesviridae Infections/immunology/*prevention & control
MH  - Humans
MH  - Immune Sera
MH  - *Immunocompromised Host
MH  - *Organ Transplantation
EDAT- 2010/11/16 06:00
MHDA- 2011/07/30 06:00
CRDT- 2010/11/16 06:00
PHST- 2010/04/22 00:00 [received]
PHST- 2010/08/25 00:00 [accepted]
PHST- 2010/08/24 00:00 [revised]
PHST- 2010/11/16 06:00 [entrez]
PHST- 2010/11/16 06:00 [pubmed]
PHST- 2011/07/30 06:00 [medline]
AID - 10.1007/s00467-010-1666-z [doi]
PST - ppublish
SO  - Pediatr Nephrol. 2011 May;26(5):663-73. doi: 10.1007/s00467-010-1666-z. Epub 2010
      Nov 15.


PMID- 21076570
OWN - NLM
STAT- MEDLINE
DCOM- 20110307
LR  - 20211020
IS  - 1564-0604 (Electronic)
IS  - 0042-9686 (Linking)
VI  - 88
IP  - 11
DP  - 2010 Nov 1
TI  - Human cells and tissues: the need for a global ethical framework.
PG  - 870-2
LID - 10.2471/BLT.09.074542 [doi]
FAU - Pirnay, Jean-Paul
AU  - Pirnay JP
AD  - Skin and Keratinocyte Bank, Burn Wound Centre, Queen Astrid Military Hospital,
      Bruynstraat 1, B-1120, Brussels, Belgium. jean-paul.pirnay@mil.be
FAU - Vanderkelen, Alain
AU  - Vanderkelen A
FAU - Zizi, Martin
AU  - Zizi M
FAU - De Vos, Daniel
AU  - De Vos D
FAU - Rose, Thomas
AU  - Rose T
FAU - Laire, Geert
AU  - Laire G
FAU - Ectors, Nadine
AU  - Ectors N
FAU - Verbeken, Gilbert
AU  - Verbeken G
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Bull World Health Organ
JT  - Bulletin of the World Health Organization
JID - 7507052
SB  - IM
MH  - *Ethics, Medical
MH  - Global Health
MH  - Health Services Needs and Demand
MH  - Humans
MH  - Tissue and Organ Procurement/*ethics/legislation & jurisprudence
MH  - World Health Organization
PMC - PMC2971509
EDAT- 2010/11/16 06:00
MHDA- 2011/03/08 06:00
CRDT- 2010/11/16 06:00
PHST- 2009/11/23 00:00 [received]
PHST- 2010/04/22 00:00 [revised]
PHST- 2010/04/29 00:00 [accepted]
PHST- 2010/11/16 06:00 [entrez]
PHST- 2010/11/16 06:00 [pubmed]
PHST- 2011/03/08 06:00 [medline]
AID - 10.2471/BLT.09.074542 [doi]
PST - ppublish
SO  - Bull World Health Organ. 2010 Nov 1;88(11):870-2. doi: 10.2471/BLT.09.074542.


PMID- 21075789
OWN - NLM
STAT- MEDLINE
DCOM- 20110426
LR  - 20211020
IS  - 1527-974X (Electronic)
IS  - 1067-5027 (Linking)
VI  - 18
IP  - 1
DP  - 2011 Jan-Feb
TI  - Challenges in ethics, safety, best practices, and oversight regarding HIT
      vendors, their customers, and patients: a report of an AMIA special task force.
PG  - 77-81
LID - 10.1136/jamia.2010.008946 [doi]
AB  - The current commercial health information technology (HIT) arena encompasses a
      number of competing firms that provide electronic health applications to
      hospitals, clinical practices, and other healthcare-related entities. Such
      applications collect, store, and analyze patient information. Some vendors
      incorporate contract language whereby purchasers of HIT systems, such as
      hospitals and clinics, must indemnify vendors for malpractice or personal injury 
      claims, even if those events are not caused or fostered by the purchasers. Some
      vendors require contract clauses that force HIT system purchasers to adopt
      vendor-defined policies that prevent the disclosure of errors, bugs, design
      flaws, and other HIT-software-related hazards. To address this issue, the AMIA
      Board of Directors appointed a Task Force to provide an analysis and insights.
      Task Force findings and recommendations include: patient safety should trump all 
      other values; corporate concerns about liability and intellectual property
      ownership may be valid but should not over-ride all other considerations;
      transparency and a commitment to patient safety should govern vendor contracts;
      institutions are duty-bound to provide ethics education to purchasers and users, 
      and should commit publicly to standards of corporate conduct; and vendors, system
      purchasers, and users should encourage and assist in each others' efforts to
      adopt best practices. Finally, the HIT community should re-examine whether and
      how regulation of electronic health applications could foster improved care,
      public health, and patient safety.
FAU - Goodman, Kenneth W
AU  - Goodman KW
AD  - Ethics Programs, University of Miami, Miami, Florida 33101, USA.
      kgoodman@miami.edu
FAU - Berner, Eta S
AU  - Berner ES
FAU - Dente, Mark A
AU  - Dente MA
FAU - Kaplan, Bonnie
AU  - Kaplan B
FAU - Koppel, Ross
AU  - Koppel R
FAU - Rucker, Donald
AU  - Rucker D
FAU - Sands, Daniel Z
AU  - Sands DZ
FAU - Winkelstein, Peter
AU  - Winkelstein P
CN  - AMIA Board of Directors
LA  - eng
PT  - Journal Article
DEP - 20101112
PL  - England
TA  - J Am Med Inform Assoc
JT  - Journal of the American Medical Informatics Association : JAMIA
JID - 9430800
SB  - IM
MH  - Commerce/ethics/legislation & jurisprudence/*standards
MH  - Confidentiality
MH  - Contracts/ethics/legislation & jurisprudence/*standards
MH  - Government Regulation
MH  - Humans
MH  - Liability, Legal
MH  - Marketing
MH  - Medical Informatics/ethics/legislation & jurisprudence/*standards
MH  - *Public Policy
MH  - *Risk Management
MH  - United States
PMC - PMC3005880
EDAT- 2010/11/16 06:00
MHDA- 2011/04/27 06:00
CRDT- 2010/11/16 06:00
PHST- 2010/11/16 06:00 [entrez]
PHST- 2010/11/16 06:00 [pubmed]
PHST- 2011/04/27 06:00 [medline]
AID - jamia.2010.008946 [pii]
AID - 10.1136/jamia.2010.008946 [doi]
PST - ppublish
SO  - J Am Med Inform Assoc. 2011 Jan-Feb;18(1):77-81. doi: 10.1136/jamia.2010.008946. 
      Epub 2010 Nov 12.


PMID- 21075559
OWN - NLM
STAT- MEDLINE
DCOM- 20120319
LR  - 20181201
IS  - 1879-355X (Electronic)
IS  - 0360-3016 (Linking)
VI  - 81
IP  - 5
DP  - 2011 Dec 1
TI  - Effect of immobilization and performance status on intrafraction motion for
      stereotactic lung radiotherapy: analysis of 133 patients.
PG  - 1568-75
LID - 10.1016/j.ijrobp.2010.09.035 [doi]
AB  - PURPOSE: To assess intrafractional geometric accuracy of lung stereotactic body
      radiation therapy (SBRT) patients treated with volumetric image guidance. METHODS
      AND MATERIALS: Treatment setup accuracy was analyzed in 133 SBRT patients treated
      via research ethics board-approved protocols. For each fraction, a localization
      cone-beam computed tomography (CBCT) scan was acquired for soft-tissue
      registration to the internal target volume, followed by a couch adjustment for
      positional discrepancies greater than 3 mm, verified with a second CBCT scan.
      CBCT scans were also performed at intrafraction and end fraction. Patient
      positioning data from 2047 CBCT scans were recorded to determine systematic
      (Sigma) and random (sigma) uncertainties, as well as planning target volume
      margins. Data were further stratified and analyzed by immobilization method
      (evacuated cushion [n=75], evacuated cushion plus abdominal compression [n=33],
      or chest board [n=25]) and by patients' Eastern Cooperative Oncology Group
      performance status (PS): 0 (n=31), 1 (n=70), or 2 (n=32). RESULTS: Using CBCT
      internal target volume was matched within +/-3 mm in 16% of all fractions at
      localization, 89% at verification, 72% during treatment, and 69% after treatment.
      Planning target volume margins required to encompass residual setup errors after 
      couch corrections (verification CBCT scans) were 4 mm, and they increased to 5 mm
      with target intrafraction motion (post-treatment CBCT scans). Small differences
      (<1 mm) in the cranial-caudal direction of target position were observed between 
      the immobilization cohorts in the localization, verification, intrafraction, and 
      post-treatment CBCT scans (p<0.01). Positional drift varied according to patient 
      PS, with the PS 1 and 2 cohorts drifting out of position by mid treatment more
      than the PS 0 cohort in the cranial-caudal direction (p=0.04). CONCLUSIONS: Image
      guidance ensures high geometric accuracy for lung SBRT irrespective of
      immobilization method or PS. A 5-mm setup margin suffices to address
      intrafraction motion. This setup margin may be further reduced by strategies such
      as frequent image guidance or volumetric arc therapy to correct or limit
      intrafraction motion.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Li, Winnie
AU  - Li W
AD  - Radiation Medicine Program, Princess Margaret Hospital, and Department of
      Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.
      winnie.li@rmp.uhn.on.ca
FAU - Purdie, Thomas G
AU  - Purdie TG
FAU - Taremi, Mojgan
AU  - Taremi M
FAU - Fung, Sharon
AU  - Fung S
FAU - Brade, Anthony
AU  - Brade A
FAU - Cho, B C John
AU  - Cho BC
FAU - Hope, Andrew
AU  - Hope A
FAU - Sun, Alexander
AU  - Sun A
FAU - Jaffray, David A
AU  - Jaffray DA
FAU - Bezjak, Andrea
AU  - Bezjak A
FAU - Bissonnette, Jean-Pierre
AU  - Bissonnette JP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101113
PL  - United States
TA  - Int J Radiat Oncol Biol Phys
JT  - International journal of radiation oncology, biology, physics
JID - 7603616
SB  - IM
MH  - Abdomen
MH  - Aged
MH  - Aged, 80 and over
MH  - Algorithms
MH  - Carcinoma, Non-Small-Cell Lung/diagnostic imaging/*surgery
MH  - Cone-Beam Computed Tomography/*methods
MH  - Constriction
MH  - Dose Fractionation, Radiation
MH  - Female
MH  - Humans
MH  - Immobilization/instrumentation/*methods
MH  - Lung/diagnostic imaging
MH  - Lung Neoplasms/diagnostic imaging/*surgery
MH  - Male
MH  - Middle Aged
MH  - *Movement
MH  - Patient Positioning
MH  - Radiosurgery/*methods
MH  - Radiotherapy Setup Errors/prevention & control
MH  - Radiotherapy, Image-Guided/methods
MH  - Reproducibility of Results
MH  - Respiration
MH  - Severity of Illness Index
MH  - Time Factors
MH  - Tumor Burden
EDAT- 2010/11/16 06:00
MHDA- 2012/03/20 06:00
CRDT- 2010/11/16 06:00
PHST- 2010/05/25 00:00 [received]
PHST- 2010/09/02 00:00 [revised]
PHST- 2010/09/28 00:00 [accepted]
PHST- 2010/11/16 06:00 [entrez]
PHST- 2010/11/16 06:00 [pubmed]
PHST- 2012/03/20 06:00 [medline]
AID - S0360-3016(10)03344-4 [pii]
AID - 10.1016/j.ijrobp.2010.09.035 [doi]
PST - ppublish
SO  - Int J Radiat Oncol Biol Phys. 2011 Dec 1;81(5):1568-75. doi:
      10.1016/j.ijrobp.2010.09.035. Epub 2010 Nov 13.


PMID- 21075491
OWN - NLM
STAT- MEDLINE
DCOM- 20110406
LR  - 20161020
IS  - 1578-1283 (Electronic)
IS  - 0213-9111 (Linking)
VI  - 24 Suppl 1
DP  - 2010 Dec
TI  - [Health in all policies, a challenge for public health in Spain. SESPAS report
      2010].
PG  - 1-6
LID - 10.1016/j.gaceta.2010.10.006 [doi]
AB  - The objective of SESPAS Report 2010 is to enhance the incorporation of the
      principle of Health in all Policies in public health in Spain. The fundamental
      principle behind this slogan is very simple: Health is strongly influenced by the
      environment, how we live, work, eat, walk or enjoy our leisure time. Moreover,
      these living conditions depend not only on individual decisions but are
      determined by social, cultural, economic or environmental factor. Consequently,
      policy decisions that influence the health of people not just those related to
      services or health policy, but primarily those taken in other public, private,
      political and civic contexts. SESPAS Report 2010 has four parts. It begins with
      and introductory chapter on the challenges of incorporating the principle of
      Health in all Policies in public health. The second part consists of several
      articles of reflection on the relationship between the health care system and
      public health. The third part focuses on cross-sectoral public health policies.
      The report ends with several articles on cross-cutting issues such as public
      health education, information, research, evaluation and ethics in public health
      policies.
CI  - Copyright (c) 2010 SESPAS. Published by Elsevier Espana. All rights reserved.
FAU - Artazcoz, Lucia
AU  - Artazcoz L
AD  - Agencia de Salut Publica de Barcelona, Barcelona, Espana. lartazco@aspb.cat
FAU - Oliva, Juan
AU  - Oliva J
FAU - Escriba-Aguir, Vicenta
AU  - Escriba-Aguir V
FAU - Zurriaga, Oscar
AU  - Zurriaga O
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - La salud en todas las politicas, un reto para la salud publica en Espana. Informe
      SESPAS 2010.
DEP - 20101113
PL  - Spain
TA  - Gac Sanit
JT  - Gaceta sanitaria
JID - 8901623
SB  - IM
EIN - Gac Sanit. 2011 May-Jun;25(3):260
MH  - Delivery of Health Care/*standards
MH  - *Health Policy
MH  - Humans
MH  - *Public Health
MH  - Spain
EDAT- 2010/11/16 06:00
MHDA- 2011/04/07 06:00
CRDT- 2010/11/16 06:00
PHST- 2010/10/18 00:00 [received]
PHST- 2010/10/25 00:00 [accepted]
PHST- 2010/11/16 06:00 [entrez]
PHST- 2010/11/16 06:00 [pubmed]
PHST- 2011/04/07 06:00 [medline]
AID - S0213-9111(10)00263-3 [pii]
AID - 10.1016/j.gaceta.2010.10.006 [doi]
PST - ppublish
SO  - Gac Sanit. 2010 Dec;24 Suppl 1:1-6. doi: 10.1016/j.gaceta.2010.10.006. Epub 2010 
      Nov 13.


PMID- 21075291
OWN - NLM
STAT- MEDLINE
DCOM- 20110323
LR  - 20161021
IS  - 1578-1291 (Electronic)
IS  - 1130-2399 (Linking)
VI  - 21
IP  - 4
DP  - 2010 Oct-Dec
TI  - [Ethics in nursing research].
PG  - 135
LID - 10.1016/j.enfi.2010.10.001 [doi]
FAU - Munoz Camargo, J C
AU  - Munoz Camargo JC
LA  - spa
PT  - Editorial
TT  - Etica en la investigacionenfermera.
PL  - Spain
TA  - Enferm Intensiva
JT  - Enfermeria intensiva
JID - 9517771
MH  - Humans
MH  - Nursing Research/*ethics
EDAT- 2010/11/16 06:00
MHDA- 2011/03/24 06:00
CRDT- 2010/11/16 06:00
PHST- 2010/10/01 00:00 [received]
PHST- 2010/10/04 00:00 [accepted]
PHST- 2010/11/16 06:00 [entrez]
PHST- 2010/11/16 06:00 [pubmed]
PHST- 2011/03/24 06:00 [medline]
AID - S1130-2399(10)00098-2 [pii]
AID - 10.1016/j.enfi.2010.10.001 [doi]
PST - ppublish
SO  - Enferm Intensiva. 2010 Oct-Dec;21(4):135. doi: 10.1016/j.enfi.2010.10.001.


PMID- 21075163
OWN - NLM
STAT- MEDLINE
DCOM- 20110404
LR  - 20211020
IS  - 1873-2518 (Electronic)
IS  - 0264-410X (Linking)
VI  - 29
IP  - 3
DP  - 2011 Jan 10
TI  - "Once Bitten, Twice Shy": participant perspectives in the aftermath of an early
      HIV vaccine trial termination.
PG  - 451-8
LID - 10.1016/j.vaccine.2010.10.076 [doi]
AB  - The Step Study phase IIb HIV-1 vaccine trial was terminated early due to
      futility; subsequent analyses revealed increased susceptibility to HIV infection 
      among a subset of test vaccine recipients. We conducted a mixed methods
      investigation, including a brief, self-administered baseline questionnaire and
      in-depth, semi-structured, 1-h interviews after unblinding, to explore
      experiences and perspectives among trial participants and key informants.
      Interviews were digitally recorded, transcribed, and analyzed using NVivo and
      thematic techniques. Forty-eight trial participants (46 gay/bisexual men)
      completed baseline surveys; 15 (14 gay/bisexual men) engaged in post-trial
      interviews. Participants indicated surprise and disappointment about the early
      trial termination and unexpected risks. Some articulated understanding the
      uncertainties of clinical trials, steadfast support and willingness to
      participate in the future; others reported greater risks than they deemed
      acceptable and unlikelihood of volunteering again. A few indicated mistrust of
      trial sponsors and ethics. Participants' most profound criticism was not about
      unexpected results, but perceived delays in unblinding and gaps in post-trial
      dissemination of information. Future HIV vaccine trials may benefit from
      increased emphasis on: (1) communication mechanisms among participants,
      investigators and trial sponsors, and (2) post-trial dissemination of information
      and psychosocial support.
CI  - Copyright A(c) 2010 Elsevier Ltd. All rights reserved.
FAU - Newman, P A
AU  - Newman PA
AD  - University of Toronto, Factor-Inwentash Faculty of Social Work, Centre for
      Applied Social Research, 246 Bloor Street West, Toronto, Ontario, Canada.
      p.newman@utoronto.ca
FAU - Yim, S
AU  - Yim S
FAU - Daley, A
AU  - Daley A
FAU - Walisser, R
AU  - Walisser R
FAU - Halpenny, R
AU  - Halpenny R
FAU - Cunningham, W
AU  - Cunningham W
FAU - Loutfy, M
AU  - Loutfy M
LA  - eng
GR  - R01 MH069087/MH/NIMH NIH HHS/United States
GR  - R01 MH069087-01A2/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101112
PL  - Netherlands
TA  - Vaccine
JT  - Vaccine
JID - 8406899
RN  - 0 (AIDS Vaccines)
SB  - IM
MH  - AIDS Vaccines/administration & dosage/*immunology
MH  - Adolescent
MH  - Adult
MH  - Early Termination of Clinical Trials/*psychology
MH  - HIV Infections/*immunology/*prevention & control
MH  - HIV-1/*immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Patient Participation/*psychology
MH  - Surveys and Questionnaires
MH  - Vaccination/*psychology
MH  - Young Adult
PMC - PMC3175433
MID - NIHMS314313
EDAT- 2010/11/16 06:00
MHDA- 2011/04/05 06:00
CRDT- 2010/11/16 06:00
PHST- 2010/04/21 00:00 [received]
PHST- 2010/10/22 00:00 [revised]
PHST- 2010/10/29 00:00 [accepted]
PHST- 2010/11/16 06:00 [entrez]
PHST- 2010/11/16 06:00 [pubmed]
PHST- 2011/04/05 06:00 [medline]
AID - S0264-410X(10)01589-6 [pii]
AID - 10.1016/j.vaccine.2010.10.076 [doi]
PST - ppublish
SO  - Vaccine. 2011 Jan 10;29(3):451-8. doi: 10.1016/j.vaccine.2010.10.076. Epub 2010
      Nov 12.


PMID- 21074986
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20131121
IS  - 1532-2963 (Electronic)
IS  - 0958-2592 (Linking)
VI  - 21
IP  - 1
DP  - 2011 Mar
TI  - The effect of socks on vertical and anteroposterior ground reaction forces in
      walking and running.
PG  - 1-5
LID - 10.1016/j.foot.2010.10.002 [doi]
AB  - BACKGROUND: Previous research suggests that socks may have the potential for
      injury protection through the absorption and/or redistribution of impact forces. 
      However, there is limited research regarding the shock attenuation qualities of
      athletic socks in sporting populations and previously observed pressure
      reductions have not been quantified using a force plate. OBJECTIVE: Firstly to
      identify the effect of specialist athletic socks on vertical and anteroposterior 
      ground reaction forces (GRFs) during walking and running. Secondly, to compare
      GRFs between specialist socks, non-specialist socks and barefoot walking and
      running conditions. METHODS: Following ethical approval participants (n=5)
      completed five walking (1.52-1.68 m s(-1)) and running (3.8-4.2 m s(-1)) trials, 
      unshod, over a force plate. This was completed before and after a 5000 m run (3.2
      m s(-1)) in their own trainers in three conditions; barefoot, non-specialist
      socks and specialist running socks. RESULTS: Significant differences were
      identified between barefoot and specialist sock conditions for pre-intervention
      time to impact peak (F=3.110((2)), P=.05, r=.11) and maximum propulsive force
      (F=8.126((2)), P=.001, r=.25) when walking. Post hoc analysis identified an
      increase of .0016 s in time to impact peak when walking barefoot compared to the 
      specialist sock condition (T=-7.402((4)), P=.002, r=.71). During walking the
      specialist sock also demonstrated a significant decrease of .075 BWs in maximum
      propulsive force when compared to the barefoot condition (T=-7.624((4)), P=.002, 
      r=.79). Both significant effects diminished following the 5000 m run. CONCLUSION:
      Findings suggest that the specialist running sock has limited effects on GRFs and
      therefore may be responsible for a limited degree of shock attenuation
      experienced during walking.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Blackmore, Tim
AU  - Blackmore T
AD  - Centre for Health, Exercise and Sport Science, Southampton Solent University,
      East Park Terrace, Hampshire, UK. tim.blackmore@solent.ac.uk
FAU - Ball, Nick
AU  - Ball N
FAU - Scurr, Joanna
AU  - Scurr J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101112
PL  - Scotland
TA  - Foot (Edinb)
JT  - Foot (Edinburgh, Scotland)
JID - 9109564
SB  - IM
MH  - Adult
MH  - Biomechanical Phenomena
MH  - *Clothing
MH  - Foot/*physiology
MH  - Humans
MH  - Male
MH  - Running/*physiology
MH  - Sports Equipment
MH  - Walking/*physiology
EDAT- 2010/11/16 06:00
MHDA- 2011/07/27 06:00
CRDT- 2010/11/16 06:00
PHST- 2010/07/14 00:00 [received]
PHST- 2010/09/28 00:00 [revised]
PHST- 2010/10/19 00:00 [accepted]
PHST- 2010/11/16 06:00 [entrez]
PHST- 2010/11/16 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
AID - S0958-2592(10)00065-9 [pii]
AID - 10.1016/j.foot.2010.10.002 [doi]
PST - ppublish
SO  - Foot (Edinb). 2011 Mar;21(1):1-5. doi: 10.1016/j.foot.2010.10.002. Epub 2010 Nov 
      12.


PMID- 21074922
OWN - NLM
STAT- MEDLINE
DCOM- 20110316
LR  - 20101220
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 72
IP  - 1
DP  - 2011 Jan
TI  - Accessing the field: Disability and the research process.
PG  - 23-30
LID - 10.1016/j.socscimed.2010.09.050 [doi]
AB  - Disability is as much a factor in interactional dynamics as ethnicity, age,
      gender or sexuality, and therefore its impact on the processes around qualitative
      research warrants much more systematic attention. Disabled researchers are not
      confined to disability studies research, although most accounts of the impact of 
      disability on the research process have, thus far, been undertaken within this
      field. This paper moves beyond this narrow focus to consider the impact of
      disabled identities and the embodied experiences of impairment on studies
      involving, primarily, non-disabled people. By reflecting on our experiences as
      visibly disabled researchers, we highlight some of the practical, ethical and
      conceptual dilemmas we encountered. Impairments may assist rapport building with 
      participants, but also introduce complex dilemmas concerning whether, when and
      how to disclose them, and the consequences of doing so. We highlight the
      centrality of the visibility of the disabled body in mediating these dilemmas,
      and its part in constraining our responses to them. While we value our commitment
      to positive readings of disability, we demonstrate that disabled researchers
      nevertheless undertake research in contexts where disability is assigned meanings
      disabled people may not share. We argue that all researchers should attend to
      their own 'body signifiers' (whether in relation to ethnicity, wealth, gender,
      age etc.) and embodied experiences of research processes, as these are integral
      to research outcomes, the ethics of research, and are a means by which to address
      power differentials between researcher and participant. This paper addresses a
      gap in the literature, using our experiences of research to highlight the
      negotiations and dilemmas faced by visibly disabled researchers. Negotiations of 
      identity prompted by the disabled body in the research process require
      consideration and should not be ignored.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Brown, Lindsey
AU  - Brown L
AD  - University of Bristol, Social Medicine, Canygne Hall, Whatley Road Clifton,
      Bristol BS8 2PS, United Kingdom. lindsey.brown@bristol.ac.uk
FAU - Boardman, Felicity K
AU  - Boardman FK
LA  - eng
PT  - Journal Article
DEP - 20101023
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Attitude to Health
MH  - *Disabled Persons
MH  - Disclosure
MH  - Female
MH  - Humans
MH  - Male
MH  - Qualitative Research
MH  - *Research
MH  - *Researcher-Subject Relations
MH  - Social Identification
EDAT- 2010/11/16 06:00
MHDA- 2011/03/17 06:00
CRDT- 2010/11/16 06:00
PHST- 2010/03/23 00:00 [received]
PHST- 2010/09/22 00:00 [revised]
PHST- 2010/09/28 00:00 [accepted]
PHST- 2010/11/16 06:00 [entrez]
PHST- 2010/11/16 06:00 [pubmed]
PHST- 2011/03/17 06:00 [medline]
AID - S0277-9536(10)00731-8 [pii]
AID - 10.1016/j.socscimed.2010.09.050 [doi]
PST - ppublish
SO  - Soc Sci Med. 2011 Jan;72(1):23-30. doi: 10.1016/j.socscimed.2010.09.050. Epub
      2010 Oct 23.


PMID- 21074134
OWN - NLM
STAT- MEDLINE
DCOM- 20110314
LR  - 20211020
IS  - 1097-6868 (Electronic)
IS  - 0002-9378 (Linking)
VI  - 204
IP  - 2
DP  - 2011 Feb
TI  - Obstetrician-gynecologists' views on contraception and natural family planning: a
      national survey.
PG  - 124.e1-7
LID - 10.1016/j.ajog.2010.08.051 [doi]
AB  - OBJECTIVE: The objective of the study was to characterize beliefs about
      contraception among obstetrician-gynecologists. STUDY DESIGN: National mailed
      survey of 1800 US obstetrician-gynecologists. Criterion variables were whether
      physicians have a moral or ethical objection to, and whether they would offer, 6 
      common contraceptive methods. Covariates included physician demographic and
      religious characteristics. RESULTS: One thousand one hundred fifty-four of 1760
      eligible obstetrician-gynecologists responded (66%). Some
      obstetrician-gynecologists object to intrauterine devices (4.4% object, 3.6%
      would not offer), progesterone implants and/or injections (1.7% object, 2.1%
      would not offer), tubal ligations (1.5% object, 1.5% would not offer), oral
      contraceptive pills (1.3% object, 1.1% would not offer), condoms (1.3% object,
      1.8% would not offer), and the diaphragm or cervical cap with spermicide (1.3%
      object, 3.3% would not offer). Religious physicians were more likely to object
      (odds ratio, 7.4) and to refuse to provide a contraceptive (odds ratio, 1.9).
      CONCLUSION: Controversies about contraception are ongoing but among
      obstetrician-gynecologists, objections and refusals to provide contraceptives are
      infrequent.
CI  - Copyright (c) 2011 Mosby, Inc. All rights reserved.
FAU - Lawrence, Ryan E
AU  - Lawrence RE
AD  - Pritzker School of Medicine, University of Chicago, Chicago, IL, USA.
      rlawrence@uchicago.edu
FAU - Rasinski, Kenneth A
AU  - Rasinski KA
FAU - Yoon, John D
AU  - Yoon JD
FAU - Curlin, Farr A
AU  - Curlin FA
LA  - eng
GR  - K23 AT002749/AT/NCCIH NIH HHS/United States
GR  - K23 AT002749-05/AT/NCCIH NIH HHS/United States
GR  - 1 K23 AT002749/AT/NCCIH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20101111
PL  - United States
TA  - Am J Obstet Gynecol
JT  - American journal of obstetrics and gynecology
JID - 0370476
SB  - IM
MH  - *Attitude of Health Personnel
MH  - *Contraception
MH  - Gynecology/statistics & numerical data
MH  - Health Care Surveys
MH  - Humans
MH  - Multivariate Analysis
MH  - Obstetrics/statistics & numerical data
MH  - Odds Ratio
MH  - *Practice Patterns, Physicians'
MH  - Religion and Medicine
MH  - United States
PMC - PMC3052964
MID - NIHMS234237
EDAT- 2010/11/16 06:00
MHDA- 2011/03/15 06:00
CRDT- 2010/11/16 06:00
PHST- 2010/06/18 00:00 [received]
PHST- 2010/08/16 00:00 [revised]
PHST- 2010/08/30 00:00 [accepted]
PHST- 2010/11/16 06:00 [entrez]
PHST- 2010/11/16 06:00 [pubmed]
PHST- 2011/03/15 06:00 [medline]
AID - S0002-9378(10)01106-3 [pii]
AID - 10.1016/j.ajog.2010.08.051 [doi]
PST - ppublish
SO  - Am J Obstet Gynecol. 2011 Feb;204(2):124.e1-7. doi: 10.1016/j.ajog.2010.08.051.
      Epub 2010 Nov 11.


PMID- 21073563
OWN - NLM
STAT- MEDLINE
DCOM- 20110310
LR  - 20220408
IS  - 1365-2834 (Electronic)
IS  - 0966-0429 (Linking)
VI  - 18
IP  - 8
DP  - 2010 Nov
TI  - Authentic leadership and nurses' voice behaviour and perceptions of care quality.
PG  - 889-900
LID - 10.1111/j.1365-2834.2010.01113.x [doi]
AB  - AIM: The purpose of the present study was to test a theoretical model linking
      authentic leadership with staff nurses' trust in their manager, work engagement, 
      voice behaviour and perceived unit care quality. BACKGROUND: Authentic leadership
      is a guide for effective leadership needed to build trust and healthier work
      environments because there is special attention given to honesty, integrity and
      high ethical standards in the development of leader-follower relationships.
      METHODS: A non-experimental, predictive survey design was used to test the
      hypothesized model in a random sample of 280 (48% response rate) registered
      nurses working in acute care hospitals in Ontario. RESULTS: The final model
      fitted the data acceptably (chi(2)=17.24, d.f.=11, P=0.10, IFI=0.99, CFI=0.99,
      RMSEA=0.045). Authentic leadership significantly and positively influenced staff 
      nurses' trust in their manager and work engagement which in turn predicted voice 
      behaviour and perceived unit care quality. CONCLUSIONS: These findings suggest
      that authentic leadership and trust in the manager play a role in fostering
      trust, work engagement, voice behaviour and perceived quality of care.
      IMPLICATIONS FOR NURSING MANAGEMENT: Nursing leaders can improve care quality and
      workplace conditions by paying attention to facilitating genuine and positive
      relationships with their staff.
CI  - (c) 2010 The Authors. Journal compilation (c) 2010 Blackwell Publishing Ltd.
FAU - Wong, Carol A
AU  - Wong CA
AD  - Faculty of Health Sciences, Arthur Labatt Family School of Nursing, The
      University of Western Ontario, London, Ontario, Canada. cwong2@uwo.ca
FAU - Spence Laschinger, Heather K
AU  - Spence Laschinger HK
FAU - Cummings, Greta G
AU  - Cummings GG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Nurs Manag
JT  - Journal of nursing management
JID - 9306050
MH  - Adult
MH  - Female
MH  - Humans
MH  - *Interpersonal Relations
MH  - *Leadership
MH  - Male
MH  - Middle Aged
MH  - Nurse Administrators/*organization & administration
MH  - Nursing Administration Research
MH  - *Nursing Staff, Hospital/organization & administration/psychology
MH  - Ontario
MH  - Organizational Culture
MH  - *Quality of Health Care
MH  - Trust
EDAT- 2010/11/16 06:00
MHDA- 2011/03/11 06:00
CRDT- 2010/11/16 06:00
PHST- 2010/11/16 06:00 [entrez]
PHST- 2010/11/16 06:00 [pubmed]
PHST- 2011/03/11 06:00 [medline]
AID - 10.1111/j.1365-2834.2010.01113.x [doi]
PST - ppublish
SO  - J Nurs Manag. 2010 Nov;18(8):889-900. doi: 10.1111/j.1365-2834.2010.01113.x.


PMID- 21073412
OWN - NLM
STAT- MEDLINE
DCOM- 20110809
LR  - 20211020
IS  - 1532-2491 (Electronic)
IS  - 1082-6084 (Linking)
VI  - 46
IP  - 6
DP  - 2011
TI  - Addiction research ethics and the Belmont principles: do drug users have a
      different moral voice?
PG  - 728-41
LID - 10.3109/10826084.2010.528125 [doi]
AB  - This study used semi-structured interviews and content analysis to examine moral 
      principles that street drug users apply to three hypothetical addiction research 
      ethical dilemmas. Participants (n = 90) were ethnically diverse, economically
      disadvantaged drug users recruited in New York City in 2009 . Participants
      applied a wide range of contextually sensitive moral precepts, including respect,
      beneficence, justice, relationality, professional obligations, rules, and
      pragmatic self-interest. Limitations and implications for future research and the
      responsible conduct of addiction research are discussed.
FAU - Fisher, Celia B
AU  - Fisher CB
AD  - Department of Psychology, Fordham University, Bronx, New York 10458, USA.
      fisher@fordham.edu
LA  - eng
GR  - R01 DA015649/DA/NIDA NIH HHS/United States
GR  - R01 DA015649-01A2/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20101115
PL  - England
TA  - Subst Use Misuse
JT  - Substance use & misuse
JID - 9602153
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Codes of Ethics
MH  - Drug Users/legislation & jurisprudence/*psychology
MH  - *Ethics, Research
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Morals
PMC - PMC3638744
MID - NIHMS458281
EDAT- 2010/11/16 06:00
MHDA- 2011/08/10 06:00
CRDT- 2010/11/16 06:00
PHST- 2010/11/16 06:00 [entrez]
PHST- 2010/11/16 06:00 [pubmed]
PHST- 2011/08/10 06:00 [medline]
AID - 10.3109/10826084.2010.528125 [doi]
PST - ppublish
SO  - Subst Use Misuse. 2011;46(6):728-41. doi: 10.3109/10826084.2010.528125. Epub 2010
      Nov 15.


PMID- 21073268
OWN - NLM
STAT- MEDLINE
DCOM- 20110303
LR  - 20101115
IS  - 1751-1402 (Electronic)
IS  - 1381-4788 (Linking)
VI  - 16
IP  - 4
DP  - 2010 Dec
TI  - Series: The research agenda for general practice/family medicine and primary
      health care in Europe. Part 5: Needs and implications for future research and
      policy.
PG  - 244-8
LID - 10.3109/13814788.2010.528385 [doi]
AB  - The recently published 'Research Agenda for General Practice/Family Medicine and 
      Primary Health Care in Europe' summarizes the evidence relating to the core
      competencies and characteristics of the Wonca Europe definition of GP/FM, and
      highlights related needs and implications for future research and policy. The
      European Journal of General Practice publishes a series of articles based on this
      document. In a first article, background, objectives, and methodology were
      discussed. In three subsequent, articles the results for the six core
      competencies of the European Definition of GP/FM were presented. This article
      formulates the common aims for further research and appropriate research
      methodologies, based on the missing evidence and research gaps identified form
      the comprehensive literature review. In addition, implications of this research
      agenda for general practitioners/family doctors, researchers, research
      organizations, patients and policy makers are presented. The concept of six core 
      competencies should be abandoned in favour of a model with four dimensions,
      including clinical, person related, community oriented and management aspects.
      Future research and policy should consider more the involvement and rights of
      patients; more attention should be given to how new treatments or technologies
      are effectively translated into routine patient care, in particular primary care.
      There is a need for a European ethics board. The promotion of GP/FM research
      demands a good infrastructure in each country, including access to literature and
      databases, appropriate funding and training possibilities.
FAU - van Royen, Paul
AU  - van Royen P
AD  - Department of Primary and Interdisciplinary Care, University of Antwerp, Belgium.
      paul.vanroyen@ua.ac.be
FAU - Beyer, Martin
AU  - Beyer M
FAU - Chevallier, Patrick
AU  - Chevallier P
FAU - Eilat-Tsanani, Sophia
AU  - Eilat-Tsanani S
FAU - Lionis, Christos
AU  - Lionis C
FAU - Peremans, Lieve
AU  - Peremans L
FAU - Petek, Davorina
AU  - Petek D
FAU - Rurik, Imre
AU  - Rurik I
FAU - Soler, Jean Karl
AU  - Soler JK
FAU - Stoffers, Henri E J H
AU  - Stoffers HE
FAU - Topsever, Pinar
AU  - Topsever P
FAU - Ungan, Mehmet
AU  - Ungan M
FAU - Hummers-Pradier, Eva
AU  - Hummers-Pradier E
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Eur J Gen Pract
JT  - The European journal of general practice
JID - 9513566
SB  - IM
CIN - Eur J Gen Pract. 2010 Dec;16(4):203-4. PMID: 21073266
MH  - *Biomedical Research
MH  - Europe
MH  - Family Practice
MH  - *General Practice
MH  - *Health Policy
MH  - *Needs Assessment
MH  - *Primary Health Care
EDAT- 2010/11/16 06:00
MHDA- 2011/03/04 06:00
CRDT- 2010/11/16 06:00
PHST- 2010/11/16 06:00 [entrez]
PHST- 2010/11/16 06:00 [pubmed]
PHST- 2011/03/04 06:00 [medline]
AID - 10.3109/13814788.2010.528385 [doi]
PST - ppublish
SO  - Eur J Gen Pract. 2010 Dec;16(4):244-8. doi: 10.3109/13814788.2010.528385.


PMID- 21073012
OWN - NLM
STAT- MEDLINE
DCOM- 20101207
LR  - 20181201
IS  - 0010-6178 (Print)
IS  - 0010-6178 (Linking)
VI  - 74
IP  - 9
DP  - 2010 Oct
TI  - Medical education: progress and retreat.
PG  - 533-7
AB  - In summary, there have been significant educational improvements, particularly
      during the first two years of medical school. Students today are more
      accomplished, more diverse, and there is now a focus on the highly relevant basic
      science of medical practice, including medical ethics and public health. The
      curriculum has been centralized and coordination between various departments has 
      vastly improved as a result. The number of lectures has been reduced, replaced by
      more effective small-group, problem-solving seminars. Support services for
      students have made medical school a much more enjoyable experience. On the other 
      hand, the dramatic shift in the nature of hospitalized patients has adversely
      affected traditional bedside teaching that was such an important part of clinical
      education in the past. Extensive diagnostic evaluations now take place in an
      ambulatory setting. Hospitals and medical schools have not yet found a
      satisfactory way to integrate trainees into these venues. Finally, there has been
      a marked decrease in the number of graduates seeking careers in primary care, a
      phenomenon influenced by huge educational debts, the attraction of being able to 
      master a defined discipline, and the desire to combine a medical life with a
      reasonable life-style. On balance, although the overall education of our future
      doctors has definitely been improved in the past fifty years, the erosion in
      fundamental clinical skills has been a disappointment.
FAU - Gifford, Robert H
AU  - Gifford RH
AD  - Yale School of Medicine, USA.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Portrait
PL  - United States
TA  - Conn Med
JT  - Connecticut medicine
JID - 0372745
SB  - IM
CIN - Conn Med. 2011 Jan;75(1):60. PMID: 21329298
MH  - Career Choice
MH  - Clinical Competence
MH  - Clinical Medicine/*history
MH  - Connecticut
MH  - Curriculum
MH  - Education, Medical/*history/methods/trends
MH  - Faculty, Medical
MH  - Female
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Male
MH  - Mentors
MH  - Schools, Medical/*history
MH  - Students, Medical/*history
EDAT- 2010/11/16 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/11/16 06:00
PHST- 2010/11/16 06:00 [entrez]
PHST- 2010/11/16 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - Conn Med. 2010 Oct;74(9):533-7.


PMID- 21072529
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20211020
IS  - 1434-4726 (Electronic)
IS  - 0937-4477 (Linking)
VI  - 268
IP  - 6
DP  - 2011 Jun
TI  - Increasing incidence of differentiated thyroid cancer in South East England:
      1987-2006.
PG  - 899-906
LID - 10.1007/s00405-010-1416-7 [doi]
AB  - There has been a worldwide increase in the incidence of thyroid cancer (TC).
      Documenting these recent trends is of immense value to cancer control measures,
      monitoring policies, improving clinical outcomes, resource allocation and
      stimulating research. Hence this study aimed to analyse the changes in incidence,
      staging and morphologic types of TC in South East England (1987-2006) by means of
      a retrospective, descriptive epidemiological study using anonymized data obtained
      from the Thames Cancer Registry (TCR) of all patients registered with TC in the
      period 1987-2006. Ethical approval was obtained from the Kent Research Ethics
      Committee. 4,880 anonymized datasets using the ICD-10 code for thyroid cancer
      (C73) were analyzed using SPSS v.17. TC was commoner amongst females 3,560 (73%) 
      than males 1,320 (27%) with a 2.7:1 ratio. Mean age at diagnosis was 53 years
      (Range 5-99) years. An increasing incidence trend was observed in early stage
      disease (p < 0.001), in young adults aged </= 49 years (p < 0.001) and in
      well-differentiated TC (papillary p < 0.001 and follicular p = 0.03). The results
      showed that TC is commoner in females than males in SE England with a 2.7:1
      ratio. The results also indicate that TC incidence has increased in SE England
      over the 20 years studied, with the greatest increase occurring in early stage
      disease, in females, young adults and well-differentiated types (papillary and
      follicular). This may be due to widespread usage of ultrasound with detection of 
      incidental nodules. Further studies are required to explain the trend.
FAU - Olaleye, Oladejo
AU  - Olaleye O
AD  - Department of Otolaryngology, Head and Neck Surgery, Queen Elizabeth Hospital,
      Birmingham, UK. dejolaleye@yahoo.com
FAU - Ekrikpo, Udeme
AU  - Ekrikpo U
FAU - Moorthy, Ram
AU  - Moorthy R
FAU - Lyne, Owen
AU  - Lyne O
FAU - Wiseberg, Jill
AU  - Wiseberg J
FAU - Black, Myles
AU  - Black M
FAU - Mitchell, David
AU  - Mitchell D
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20101112
PL  - Germany
TA  - Eur Arch Otorhinolaryngol
JT  - European archives of oto-rhino-laryngology : official journal of the European
      Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the
      German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JID - 9002937
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Distribution
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - Child, Preschool
MH  - England/epidemiology
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - *Neoplasm Staging
MH  - *Registries
MH  - Retrospective Studies
MH  - Sex Distribution
MH  - Thyroid Neoplasms/*epidemiology/pathology
MH  - Young Adult
EDAT- 2010/11/13 06:00
MHDA- 2011/11/16 06:00
CRDT- 2010/11/13 06:00
PHST- 2010/06/22 00:00 [received]
PHST- 2010/10/22 00:00 [accepted]
PHST- 2010/11/13 06:00 [entrez]
PHST- 2010/11/13 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - 10.1007/s00405-010-1416-7 [doi]
PST - ppublish
SO  - Eur Arch Otorhinolaryngol. 2011 Jun;268(6):899-906. doi:
      10.1007/s00405-010-1416-7. Epub 2010 Nov 12.


PMID- 21072455
OWN - NLM
STAT- MEDLINE
DCOM- 20110406
LR  - 20220408
IS  - 1726-4642 (Electronic)
IS  - 1726-4634 (Linking)
VI  - 27
IP  - 1
DP  - 2010 Mar
TI  - [Beyond the indigenous: health and interculturality at the global level].
PG  - 94-101
LID - S1726-46342010000100014 [pii]
AB  - Health inequalities are broadly documented for ethnic minority groups and
      immigrants worldwide. Intercultural perspectives in health are thus developed in 
      very different places and situations. Both the criteria for defining the target
      groups as well as the ways the health problems of these groups are looked at, are
      shaped by the particular local context. However, some challenges are common to
      almost all situations where the topic of ethnic diversity and health is
      considered. And in contrast to the rather novel term, the issues at stake in
      "intercultural heath" are not new at all. Against this background, the present
      article brings into focus three essential points: the necessity of defining
      ethnicity adequately to avoid stereotyping and the creation of new inequalities; 
      the challenge of converting ethnicity into a helpful and thus "healthy" category 
      in the field of medicine and health; and the need for the integration of explicit
      and serious reflections on medical ethics and human rights that provide for the
      normative framework and moral orientation of health activities with indigenous,
      migrant and other particularly vulnerable groups.
FAU - Knipper, Michael
AU  - Knipper M
AD  - Justus-Liebig-Universitat, Giessen, Germany.
      Michael.Knipper@histor.med.uni-giessen.de
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Mas alla de lo indigena: salud e interculturalidad a nivel global.
PL  - Peru
TA  - Rev Peru Med Exp Salud Publica
JT  - Revista peruana de medicina experimental y salud publica
JID - 101227566
SB  - IM
MH  - *Cultural Diversity
MH  - *Health
MH  - Humans
MH  - *Indians, South American
MH  - Internationality
MH  - Peru
EDAT- 2010/11/13 06:00
MHDA- 2011/04/07 06:00
CRDT- 2010/11/13 06:00
PHST- 2010/11/13 06:00 [entrez]
PHST- 2010/11/13 06:00 [pubmed]
PHST- 2011/04/07 06:00 [medline]
AID - S1726-46342010000100014 [pii]
AID - 10.1590/s1726-46342010000100014 [doi]
PST - ppublish
SO  - Rev Peru Med Exp Salud Publica. 2010 Mar;27(1):94-101. doi:
      10.1590/s1726-46342010000100014.


PMID- 21071948
OWN - NLM
STAT- MEDLINE
DCOM- 20110411
LR  - 20161125
IS  - 1421-9913 (Electronic)
IS  - 0014-3022 (Linking)
VI  - 64
IP  - 6
DP  - 2010
TI  - Safety of pharmacological augmentation of stroke rehabilitation.
PG  - 325-30
LID - 10.1159/000322134 [doi]
AB  - BACKGROUND: Based on experimental studies, pharmacological augmentation (PA) of
      stroke rehabilitation might be reasonable. Whether PA is beneficial in clinical
      practice is unclear. METHODS: We performed an observational study on the use of
      PA in addition to regular rehabilitative therapies in a stroke rehabilitation
      unit. Over 20 months, we systematically observed (1) the utilization rate of PA, 
      (2) possible adverse events, and (3) the functional outcome of patients with
      versus without PA (non-PA). The primary outcome variable was the increase in
      abilities in activities of daily living during in-hospital rehabilitation as
      quantified by the delta 'functional independence measure' (FIM). RESULTS:
      Ninety-seven of 249 (39%) patients had PA. L-Dopa was used in 63 (65%),
      acetylcholinesterase inhibitors in 33 (34%), and selective serotonin reuptake
      inhibitors in 31 (32%) PA patients. In 11 (11%) patients, PA was associated with 
      delirium (n = 4), gastrointestinal symptoms (n = 4), electrolyte disorders (n =
      2), or incontinence (n = 1). All adverse events were temporary. PA patients did
      not differ from non-PA patients in age (74 vs. 73 years; p = 0.62), gender ratio,
      and stroke type (ischemia 85 vs. 82%; p = 0.49). However, compared with non-PA
      patients, PA patients were more severely affected (median NIH Stroke Scale Score 
      7 vs. 4; p < 0.001; median FIM 58 vs. 85; p = 0.01). At discharge, the PA group
      had a higher median DeltaFIM compared with non-PA patients (16 vs. 9; p = 0.01). 
      None of the PA patients but 5 (3.3%) of the non-PA patients had died. CONCLUSION:
      PA of stroke rehabilitation was used frequently. The absence of safety concerns
      suggests that there is scope for benefit from PA in stroke rehabilitation. A
      large randomized controlled trial seems feasible and ethically justified.
CI  - Copyright 2010 S. Karger AG, Basel.
FAU - Engelter, Stefan T
AU  - Engelter ST
AD  - Neurorehabilitation Unit, Geriatric Competence Center, Felix Platter-Spital,
      Basel, Switzerland. stefan.engelter@fps-basel-ch
FAU - Frank, Matthias
AU  - Frank M
FAU - Lyrer, Philippe A
AU  - Lyrer PA
FAU - Conzelmann, Martin
AU  - Conzelmann M
LA  - eng
PT  - Journal Article
DEP - 20101113
PL  - Switzerland
TA  - Eur Neurol
JT  - European neurology
JID - 0150760
RN  - 0 (Cholinesterase Inhibitors)
RN  - 0 (Dopamine Agents)
RN  - 0 (Serotonin Uptake Inhibitors)
SB  - IM
MH  - Activities of Daily Living
MH  - Aged
MH  - Cholinesterase Inhibitors/*therapeutic use
MH  - Dopamine Agents/*therapeutic use
MH  - Female
MH  - Humans
MH  - Male
MH  - Recovery of Function/*drug effects
MH  - Serotonin Uptake Inhibitors/*therapeutic use
MH  - Stroke/*drug therapy
MH  - *Stroke Rehabilitation
EDAT- 2010/11/13 06:00
MHDA- 2011/04/13 06:00
CRDT- 2010/11/13 06:00
PHST- 2010/07/13 00:00 [received]
PHST- 2010/10/18 00:00 [accepted]
PHST- 2010/11/13 06:00 [entrez]
PHST- 2010/11/13 06:00 [pubmed]
PHST- 2011/04/13 06:00 [medline]
AID - 000322134 [pii]
AID - 10.1159/000322134 [doi]
PST - ppublish
SO  - Eur Neurol. 2010;64(6):325-30. doi: 10.1159/000322134. Epub 2010 Nov 13.


PMID- 21071581
OWN - NLM
STAT- MEDLINE
DCOM- 20101210
LR  - 20101112
IS  - 1468-3288 (Electronic)
IS  - 0017-5749 (Linking)
VI  - 59
IP  - 12
DP  - 2010 Dec
TI  - The provision of a percutaneously placed enteral tube feeding service.
PG  - 1592-605
LID - 10.1136/gut.2009.204982 [doi]
AB  - There is overwhelming evidence that the maintenance of enteral feeding is
      beneficial in patients in whom oral access has been diminished or lost.
      Short-term enteral access is usually achieved via naso-enteral tube placement.
      For longer term tube feeding there are recognised advantages for enteral feeding 
      tubes placed percutaneously. The provision of a percutaneous enteral tube feeding
      service should be within the remit of the hospital nutrition support team (NST). 
      This designated team should provide a framework for patient selection,
      pre-assessment and post-procedural care. Close working relations with
      community-based services should be established. An accredited therapeutic
      endoscopist should be a member of the NST and direct the technical aspects of the
      service. Every endoscopy unit in an acute hospital setting should provide a basic
      percutaneous endoscopic gastrostomy (PEG) service. This should include provision 
      for fitting a PEG jejunal extension (PEGJ) if required. Specialist units should
      be identified where a more comprehensive service is provided, including direct
      jejunal placement (DPEJ), as well as radiological and laparoscopically placed
      tubes. Good understanding of the indications for percutaneous enteral tube
      feeding will prevent inappropriate procedures and ensure that the correct feeding
      route is selected at the appropriate time. Each unit should adopt and become
      familiar with a limited range of PEG tube equipment. Careful adherence to the
      important technical details of tube insertion will reduce peri-procedural
      complications. Post-procedural complications remain relatively common, however,
      and an awareness of the correct approach to managing them is essential for all
      clinicians involved in providing a percutaneous enteral tube feeding service.
      Finally, ethical considerations should always be taken into account when
      considering long-term enteral feeding, especially for patients with a poor
      quality of life.
FAU - Westaby, David
AU  - Westaby D
AD  - Department of Gastroenterology Hammersmith Hospital Site, Imperial College
      Healthcare NHS Trust, London W12 0HS, UK. david.westaby@imperial.nhs.uk
FAU - Young, Alison
AU  - Young A
FAU - O'Toole, Paul
AU  - O'Toole P
FAU - Smith, Geoff
AU  - Smith G
FAU - Sanders, David S
AU  - Sanders DS
LA  - eng
PT  - Journal Article
PT  - Practice Guideline
PL  - England
TA  - Gut
JT  - Gut
JID - 2985108R
SB  - IM
MH  - Delivery of Health Care, Integrated/*organization & administration
MH  - Enteral Nutrition/adverse effects/ethics/instrumentation/*methods
MH  - Equipment Failure
MH  - Ethics, Medical
MH  - Evidence-Based Medicine/methods
MH  - Gastrostomy/methods
MH  - Humans
MH  - Patient Care Team/organization & administration
MH  - Patient Selection
MH  - Peritonitis/etiology
MH  - Pneumonia/etiology
EDAT- 2010/11/13 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/11/13 06:00
PHST- 2010/11/13 06:00 [entrez]
PHST- 2010/11/13 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 59/12/1592 [pii]
AID - 10.1136/gut.2009.204982 [doi]
PST - ppublish
SO  - Gut. 2010 Dec;59(12):1592-605. doi: 10.1136/gut.2009.204982.


PMID- 21071569
OWN - NLM
STAT- MEDLINE
DCOM- 20110506
LR  - 20220309
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 2
DP  - 2011 Feb
TI  - Ethics of modifying the mitochondrial genome.
PG  - 97-100
LID - 10.1136/jme.2010.037481 [doi]
AB  - Recent preclinical studies have shown the feasibility of specific variants of
      nuclear transfer to prevent mitochondrial DNA disorders. Nuclear transfer could
      be a valuable reproductive option for carriers of mitochondrial mutations. A
      clinical application of nuclear transfer, however, would entail germ-line
      modification, more specifically a germ-line modification of the mitochondrial
      genome. One of the most prominent objections against germ-line modification is
      the fear that it would become possible to alter 'essential characteristics' of a 
      future person, thereby possibly violating the child's right to an open future. As
      only the nuclear DNA would contain the ingredients for individual
      characteristics, modification of the mtDNA is often considered less controversial
      than modification of the nuclear DNA. This paper discusses the tenability of this
      dichotomy. After having clarified the concept of germ-line modification, it
      argues that modification of the mtDNA is not substantively different from
      modification of the nuclear DNA in terms of its effects on the identity of the
      future person. Subsequently the paper assesses how this conclusion affects the
      moral evaluation of nuclear transfer to prevent mtDNA disorders. It concludes
      that the moral acceptability of germ-line modification does not depend on whether
      it alters the identity of the future child-all germ-line modifications do-but on 
      whether it safeguards the child's right to an open future. If nuclear transfer to
      prevent mtDNA disorders becomes safe and effective, then dismissing it because it
      involves germ-line modification is unjustified.
FAU - Bredenoord, A L
AU  - Bredenoord AL
AD  - Julius Center for Health Sciences and Primary Care, University Medical Center
      Utrecht, Stratenum, 6.131, PO Box 85500, 3508 GA Utrecht, The Netherlands.
      a.l.bredenoord@umcutrecht.nl
FAU - Dondorp, W
AU  - Dondorp W
FAU - Pennings, G
AU  - Pennings G
FAU - De Wert, G
AU  - De Wert G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101111
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
RN  - 0 (DNA, Mitochondrial)
SB  - IM
MH  - Bioethical Issues
MH  - DNA, Mitochondrial/*genetics
MH  - Female
MH  - Genetic Engineering/*ethics
MH  - Genome, Mitochondrial/*genetics
MH  - Humans
MH  - Male
MH  - Mitochondrial Diseases/*genetics
MH  - Nuclear Transfer Techniques/*ethics
MH  - Pregnancy
EDAT- 2010/11/13 06:00
MHDA- 2011/05/07 06:00
CRDT- 2010/11/13 06:00
PHST- 2010/11/13 06:00 [entrez]
PHST- 2010/11/13 06:00 [pubmed]
PHST- 2011/05/07 06:00 [medline]
AID - jme.2010.037481 [pii]
AID - 10.1136/jme.2010.037481 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Feb;37(2):97-100. doi: 10.1136/jme.2010.037481. Epub 2010 Nov 
      11.


PMID- 21071567
OWN - NLM
STAT- MEDLINE
DCOM- 20110506
LR  - 20211020
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 2
DP  - 2011 Feb
TI  - Ethical challenges in fetal surgery.
PG  - 88-91
LID - 10.1136/jme.2010.039537 [doi]
AB  - Fetal surgery has been practised for some decades now. However, it remains a
      highly complex area, both medically and ethically. This paper shows how the
      routine use of ultrasound has been a catalyst for fetal surgery, in creating new 
      needs and new incentives for intervention. Some of the needs met by fetal surgery
      are those of parents and clinicians who experience stress while waiting for the
      birth of a fetus with known anomalies. The paper suggests that the role of
      technology and visualisation techniques in creating and meeting such new needs is
      ethically problematic. It then addresses the idea that fetal surgery should be
      restricted to interventions that are life-saving for the fetus, arguing that this
      restriction is unduly paternalistic. Fetal surgery poses challenges for an
      autonomy-based system of ethics. However, it is risky to circumvent these
      challenges by restricting the choices open to pregnant women, even when these
      choices appear excessively altruistic.
FAU - Smajdor, Anna
AU  - Smajdor A
AD  - School of Medicine, Health Policy and Practice, University of East Anglia,
      Norwich NR4 7TJ, UK. a.smajdor@uea.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20101111
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Bioethical Issues
MH  - Congenital Abnormalities/*surgery
MH  - Female
MH  - Fetal Diseases/*surgery
MH  - Fetus/*surgery
MH  - Humans
MH  - Informed Consent/*ethics/standards
MH  - Patient Rights/ethics
MH  - Personal Autonomy
MH  - Pregnancy
MH  - Pregnant Women/psychology
MH  - Risk Factors
MH  - Ultrasonography, Prenatal/ethics/psychology
PMC - PMC3030775
EDAT- 2010/11/13 06:00
MHDA- 2011/05/07 06:00
CRDT- 2010/11/13 06:00
PHST- 2010/11/13 06:00 [entrez]
PHST- 2010/11/13 06:00 [pubmed]
PHST- 2011/05/07 06:00 [medline]
AID - jme.2010.039537 [pii]
AID - 10.1136/jme.2010.039537 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Feb;37(2):88-91. doi: 10.1136/jme.2010.039537. Epub 2010 Nov
      11.


PMID- 21071129
OWN - NLM
STAT- MEDLINE
DCOM- 20110201
LR  - 20211020
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 71
IP  - 12
DP  - 2010 Dec
TI  - Fresh or frozen? Classifying 'spare' embryos for donation to human embryonic stem
      cell research.
PG  - 2204-11
LID - 10.1016/j.socscimed.2010.09.045 [doi]
AB  - United Kingdom (UK) funding to build human embryonic stem cell (hESC) derivation 
      labs within assisted conception units (ACU) was intended to facilitate the
      'In-vitro fertilisation (IVF)-stem cell interface', including the flow of fresh
      'spare' embryos to stem cell labs. However, in the three sites reported on here, 
      which received this funding, most of the embryos used for hESC research came from
      long term cryopreservation storage and/or outside clinics. In this paper we
      explore some of the clinical, technical, social and ethical factors that might
      help to explain this situation. We report from our qualitative study of the
      ethical frameworks for approaching women/couples for donation of embryos to stem 
      cell research. Members of staff took part in 44 interviews and six ethics
      discussion groups held at our study sites between February 2008 and October 2009.
      We focus here on their articulations of social and ethical, as well as
      scientific, dimensions in the contingent classification of 'spare' embryos,
      entailing uncertainty, fluidity and naturalisation in classifying work. Social
      and ethical factors include acknowledging and responding to uncertainty in
      classifying embryos; retaining 'fluidity' in the grading system to give embryos
      'every chance'; tensions between standardisation and variation in enacting a
      'fair' grading system; enhancement of patient choice and control, and prevention 
      of regret; and incorporation of patients' values in construction of ethically
      acceptable embryo 'spareness' ('frozen' embryos, and embryos determined through
      preimplantation genetic diagnosis (PGD) to be genetically 'affected'). We argue
      that the success of the 'built moral environment' of ACU with adjoining stem cell
      laboratories building projects intended to facilitate the 'IVF-stem cell
      interface' may depend not only on architecture, but also on the part such social 
      and ethical factors play in configuration of embryos as particular kinds of moral
      work objects.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Ehrich, Kathryn
AU  - Ehrich K
AD  - King's College London, UK. Kathryn.Ehrich@kcl.ac.uk
FAU - Williams, Clare
AU  - Williams C
FAU - Farsides, Bobbie
AU  - Farsides B
LA  - eng
GR  - 086034/WT_/Wellcome Trust/United Kingdom
GR  - 081414/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101021
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Cryopreservation
MH  - Embryo Disposition/ethics/*psychology
MH  - Embryonic Stem Cells
MH  - Female
MH  - Fertilization in Vitro
MH  - Humans
MH  - Professional-Patient Relations/*ethics
MH  - Qualitative Research
MH  - *Stem Cell Research
MH  - Tissue and Organ Procurement/*ethics
MH  - United Kingdom
PMC - PMC3003156
EDAT- 2010/11/13 06:00
MHDA- 2011/02/02 06:00
CRDT- 2010/11/13 06:00
PHST- 2010/01/19 00:00 [received]
PHST- 2010/09/25 00:00 [revised]
PHST- 2010/09/27 00:00 [accepted]
PHST- 2010/11/13 06:00 [entrez]
PHST- 2010/11/13 06:00 [pubmed]
PHST- 2011/02/02 06:00 [medline]
AID - S0277-9536(10)00723-9 [pii]
AID - 10.1016/j.socscimed.2010.09.045 [doi]
PST - ppublish
SO  - Soc Sci Med. 2010 Dec;71(12):2204-11. doi: 10.1016/j.socscimed.2010.09.045. Epub 
      2010 Oct 21.


PMID- 21071107
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20220410
IS  - 1872-6054 (Electronic)
IS  - 0168-8510 (Linking)
VI  - 102
IP  - 2-3
DP  - 2011 Oct
TI  - Health technology prioritization: which criteria for prioritizing new
      technologies and what are their relative weights?
PG  - 126-35
LID - 10.1016/j.healthpol.2010.10.012 [doi]
AB  - OBJECTIVES: To review the criteria and 'other' considerations used
      internationally for prioritizing new health technologies, and to demonstrate a
      conjoint-analysis methodology (also known as discrete choice experiments) for
      deriving relative weights for the criteria. METHODS: We searched the literature
      for criteria and other considerations for prioritizing new technologies. A
      convenience sample of 74 respondents completed a conjoint-analysis survey
      involving criteria related to technologies' 'benefits'. RESULTS: Encompassing 11 
      countries and the US state of Oregon, we were able to distinguish three main
      groups of criteria: (a) Need, appropriateness and clinical benefits; (b)
      Efficiency (including cost-effectiveness); and (c) Equality, solidarity and other
      ethical or social values. For several countries, the quality of the clinical and 
      economic evidence and factors related to strategic issues and procedural justice 
      respectively are also considered. The criteria and their weights from the
      conjoint-analysis survey are: 'Lives saved'=0.343, 'Life-prolongation
      benefits'=0.243, 'Quality-of-life gains'=0.217, a criterion representing the
      availability of alternative treatments=0.107, and 'Other important social/ethical
      benefits'=0.087. CONCLUSIONS: The criteria represent a pluralistic combination of
      needs-based, maximizing and egalitarian principles, and we demonstrated a
      methodology for deriving the weights for criteria related to technologies'
      'benefits'.
CI  - Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Golan, Ofra
AU  - Golan O
AD  - The Gertner Institute for Epidemiology & Health Policy Research, Chaim Sheba
      Medical Center, Tel Hashomer 52621, Israel. ofragolan6@gmail.com
FAU - Hansen, Paul
AU  - Hansen P
FAU - Kaplan, Giora
AU  - Kaplan G
FAU - Tal, Orna
AU  - Tal O
LA  - eng
PT  - Journal Article
DEP - 20101111
PL  - Ireland
TA  - Health Policy
JT  - Health policy (Amsterdam, Netherlands)
JID - 8409431
MH  - *Biomedical Technology
MH  - Cost-Benefit Analysis
MH  - Decision Making
MH  - *Health Care Rationing/ethics
MH  - *Health Policy
MH  - *Health Priorities/ethics
MH  - Health Services Needs and Demand
MH  - Humans
MH  - Policy Making
MH  - Quality of Life
EDAT- 2010/11/13 06:00
MHDA- 2012/01/27 06:00
CRDT- 2010/11/13 06:00
PHST- 2010/06/25 00:00 [received]
PHST- 2010/10/13 00:00 [revised]
PHST- 2010/10/13 00:00 [accepted]
PHST- 2010/11/13 06:00 [entrez]
PHST- 2010/11/13 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - S0168-8510(10)00306-4 [pii]
AID - 10.1016/j.healthpol.2010.10.012 [doi]
PST - ppublish
SO  - Health Policy. 2011 Oct;102(2-3):126-35. doi: 10.1016/j.healthpol.2010.10.012.
      Epub 2010 Nov 11.


PMID- 21070661
OWN - NLM
STAT- MEDLINE
DCOM- 20110204
LR  - 20211020
IS  - 1824-7288 (Electronic)
IS  - 1720-8424 (Linking)
VI  - 36
DP  - 2010 Nov 11
TI  - Toward a bioethical issue: induced multiple pregnancies and neonatal outcomes.
PG  - 74
LID - 10.1186/1824-7288-36-74 [doi]
AB  - Assisted reproductive technology has made great progress during the last three
      decades. After the initial enthusiasm, many ethical, legal and social issues
      related to the application of these procedures began to evolve. Multifetal
      pregnancy and fetal reduction, embryo cryopreservation, preimplantation genetic
      diagnosis, risks of birth defects and other adverse outcome associated with
      assisted reproductive technology are issues that have to be addressed building
      future collaborative studies and continuing the debate on related ethical issues.
FAU - Zuppa, Antonio A
AU  - Zuppa AA
AD  - Department of Pediatrics, Division of Neonatology, Catholic University of Sacred 
      Heart, Largo Gemelli, 00168 Roma, Italy. zuppaaa@rm.unicatt.it
FAU - Alighieri, Giovanni
AU  - Alighieri G
FAU - Catenazzi, Piero
AU  - Catenazzi P
FAU - Scorrano, Antonio
AU  - Scorrano A
FAU - Romagnoli, Costantino
AU  - Romagnoli C
LA  - eng
PT  - Journal Article
DEP - 20101111
PL  - England
TA  - Ital J Pediatr
JT  - Italian journal of pediatrics
JID - 101510759
SB  - IM
MH  - Congenital Abnormalities
MH  - Counseling
MH  - Cryopreservation
MH  - Embryo, Mammalian
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Pregnancy
MH  - Pregnancy Reduction, Multifetal
MH  - Pregnancy, Multiple
MH  - Preimplantation Diagnosis
MH  - Reproductive Techniques, Assisted/*ethics
PMC - PMC2995785
EDAT- 2010/11/13 06:00
MHDA- 2011/02/05 06:00
CRDT- 2010/11/13 06:00
PHST- 2010/08/13 00:00 [received]
PHST- 2010/11/11 00:00 [accepted]
PHST- 2010/11/13 06:00 [entrez]
PHST- 2010/11/13 06:00 [pubmed]
PHST- 2011/02/05 06:00 [medline]
AID - 1824-7288-36-74 [pii]
AID - 10.1186/1824-7288-36-74 [doi]
PST - epublish
SO  - Ital J Pediatr. 2010 Nov 11;36:74. doi: 10.1186/1824-7288-36-74.


PMID- 21070437
OWN - NLM
STAT- MEDLINE
DCOM- 20110228
LR  - 20101112
IS  - 1524-4741 (Electronic)
IS  - 1075-122X (Linking)
VI  - 16
IP  - 6
DP  - 2010 Nov-Dec
TI  - The necrosis sign in magnetic resonance-mammography: diagnostic accuracy in 1,084
      histologically verified breast lesions.
PG  - 603-8
LID - 10.1111/j.1524-4741.2010.00982.x [doi]
AB  - Necrosis sign (NS) is a new descriptor for differential diagnosis of breast
      lesions in magnetic resonance (MR)-mammography (MRM). This study was designed:
      (a) to analyze diagnostic accuracy of NS in 1,084 histologically verified breast 
      lesions, (b) to assess performance of NS in subgroups. This study was approved by
      the local ethical committee. All histologically verified lesions having undergone
      MR-mammography at our institution over 12 years were evaluated by experienced
      radiologists (> 500 MRM) according to standard protocols and study design (T1w;
      0.1 mmol/kg bw gadolinium diethylenetriamine penta-acetic acid; T2-turbo spin
      echo (TSE)). Patients with history of breast biopsy (surgically,
      minimal-invasive), radiation- or chemotherapy </= 1 year before MRM were
      excluded. NS was assessed on T2w-TSE sequences and was rated positive if a
      hyperintense center in a hypointense lesion could be visualized (chi-squared
      test). One thousand and eighty-four lesions were available for statistical
      analysis (648: malignant, 436: benign). NS was significantly associated with
      malignancy (p < 0.001), providing specificity and positive predictive value (PPV)
      of 96.1% and 78.8%. Malignant lesions > 20 mm presented significantly more often 
      NS (p < 0.001) than neoplasias </= 20 mm. There was no difference regarding
      prevalence of NS in small versus advanced benign lesions (n.s.), leading to
      better performance of NS in lesions > 20 mm (PPV: 87.8%). Correlation between NS 
      and Grading of invasive carcinomas was significant. In this study of 1,084
      lesions necrosis sign was a specific and highly predictive feature for
      differential diagnosis in MRM (Specificity: 96.1%; PPV: 78.8%). This particularly
      counts for advanced lesions (PPV 87.8%). As this new descriptor correlates with
      Grading, it could be used as an initial estimate of patient's prognosis.
CI  - (c) 2010 Wiley Periodicals, Inc.
FAU - Dietzel, Matthias
AU  - Dietzel M
AD  - Institute of Diagnostic and Interventional Radiology,
      Friedrich-Schiller-University Jena, Germany. matthias.dietzel@med.uni-jena.de
FAU - Baltzer, Pascal A T
AU  - Baltzer PA
FAU - Vag, Tibor
AU  - Vag T
FAU - Herzog, Aimee
AU  - Herzog A
FAU - Gajda, Mieczyslaw
AU  - Gajda M
FAU - Camara, Oumar
AU  - Camara O
FAU - Kaiser, Werner A
AU  - Kaiser WA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Breast J
JT  - The breast journal
JID - 9505539
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Breast/*pathology
MH  - Breast Neoplasms/*diagnosis/pathology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - *Mammography
MH  - Middle Aged
MH  - Necrosis
EDAT- 2010/11/13 06:00
MHDA- 2011/03/01 06:00
CRDT- 2010/11/13 06:00
PHST- 2010/11/13 06:00 [entrez]
PHST- 2010/11/13 06:00 [pubmed]
PHST- 2011/03/01 06:00 [medline]
AID - 10.1111/j.1524-4741.2010.00982.x [doi]
PST - ppublish
SO  - Breast J. 2010 Nov-Dec;16(6):603-8. doi: 10.1111/j.1524-4741.2010.00982.x.


PMID- 21070299
OWN - NLM
STAT- MEDLINE
DCOM- 20110217
LR  - 20161125
IS  - 1539-6924 (Electronic)
IS  - 0272-4332 (Linking)
VI  - 30
IP  - 11
DP  - 2010 Nov
TI  - Responsible innovation: a pilot study with the U.K. Engineering and Physical
      Sciences Research Council.
PG  - 1699-707
LID - 10.1111/j.1539-6924.2010.01517.x [doi]
AB  - Significant time lags between the development of novel innovations (e.g.,
      nanotechnologies), understanding of their wider impacts, and subsequent
      governance (e.g., regulation) have led to repeated calls for more anticipatory
      and adaptive approaches that promote the responsible emergence of new
      technologies in democratic societies. A key challenge is implementation in a
      pragmatic way. Results are presented of a study with the Engineering and Physical
      Sciences Research Council, the largest public funder of basic innovation research
      in the United Kingdom who, for the first time, asked applicants to submit a risk 
      register identifying the wider potential impacts and associated risks
      (environment, health, societal, and ethical) of their proposed research. This
      focused on nanoscience for carbon capture and utilization. Risk registers were
      completed conservatively, with most identified impacts concerning researchers'
      health associated with nanoparticle synthesis, handling, and prototype device
      fabrication, i.e., risks that could be identified and managed with a reasonable
      level of certainty. Few wider environmental impacts and no future impacts on
      society were identified, reflecting the often uncertain and unpredictable nature 
      of innovation. However, some applicants addressed this by including investigators
      with expertise beyond engineering and nanosciences supporting integrated
      activities that included life cycle and real-time technology assessment, which in
      some cases were also framed by stakeholder and/or public engagement. Proposals
      underpinned by a strong commitment to responsible science and innovation promoted
      continuous reflexivity, embedding a suite of multidisciplinary approaches around 
      the innovation research core to support decisions modulating the trajectory of
      their innovation research in real-time.
FAU - Owen, Richard
AU  - Owen R
AD  - European Centre for Environment and Human Health, PeninsulaCollege of Medicine
      and Dentristy, Truro, UK. richard.owen@pcmd.ac.uk
FAU - Goldberg, Nicola
AU  - Goldberg N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Risk Anal
JT  - Risk analysis : an official publication of the Society for Risk Analysis
JID - 8109978
SB  - IM
MH  - *Academies and Institutes
MH  - *Nanotechnology
MH  - Pilot Projects
MH  - United Kingdom
EDAT- 2010/11/13 06:00
MHDA- 2011/02/18 06:00
CRDT- 2010/11/13 06:00
PHST- 2010/11/13 06:00 [entrez]
PHST- 2010/11/13 06:00 [pubmed]
PHST- 2011/02/18 06:00 [medline]
AID - 10.1111/j.1539-6924.2010.01517.x [doi]
PST - ppublish
SO  - Risk Anal. 2010 Nov;30(11):1699-707. doi: 10.1111/j.1539-6924.2010.01517.x.


PMID- 21070132
OWN - NLM
STAT- MEDLINE
DCOM- 20110429
LR  - 20101228
IS  - 1556-3669 (Electronic)
IS  - 1530-5627 (Linking)
VI  - 16
IP  - 10
DP  - 2010 Dec
TI  - A review on remote monitoring technology applied to implantable electronic
      cardiovascular devices.
PG  - 1042-50
LID - 10.1089/tmj.2010.0082 [doi]
AB  - Implantable electronic cardiovascular devices (IECD) include a broad spectrum of 
      devices that have the ability to maintain rhythm, provide cardiac
      resynchronization therapy, and/or prevent sudden cardiac death. The incidence of 
      bradyarrhythmias and other cardiac problems led to a broader use of IECD, which
      turned traditional follow-up into an extremely heavy burden for healthcare
      systems to support. Our aim was to assess the impact of remote monitoring on the 
      follow-up of patients with IECD. We performed a review through PubMed using a
      specific query. The paper selection process included a three-step approach in
      which title, abstract, and cross-references were analyzed. Studies were then
      selected using previously defined inclusion criteria and analyzed according to
      the country of origin of the study, year, and journal of publication; type of
      study; and main issues covered. Twenty articles were included in this review.
      Eighty percent of the selected papers addressed clinical issues, from which 94%
      referred clinical events identification, clinical stability, time savings, or
      physician satisfaction as advantages, whereas 38% referred disadvantages that
      included both legal and technical issues. Forty-five percent of the papers
      referred patient issues, from which 89% presented advantages, focusing on patient
      acceptance/satisfaction, and patient time-savings. The main downsides were
      technical issues but patient privacy was also addressed. All the papers dealing
      with economic issues (20%) referred both advantages and disadvantages equally.
      Remote monitoring is presently a safe technology, widely accepted by patients and
      physicians, for its convenience, reassurance, and diagnostic potential. This
      review summarizes the principles of remote IECD monitoring presenting the current
      state-of-the-art. Patient safety and device interaction, applicability of current
      technology, and limitations of remote IECD monitoring are also addressed. The use
      of remote monitor should consider the selection of patients, the type of disease,
      and centers' availability to receive, interpret and respond to device alerts.
      Before remote IECD monitoring can be routinely used, technical, procedure, and
      ethical/legal issues should be addressed.
FAU - Costa, Paulo Dias
AU  - Costa PD
AD  - Department of Biostatistics and Medical Informatics-Faculty of Medicine,
      University of Porto, Porto, Portugal. paulocosta.cardiologia@hgsa.min-saude.pt
FAU - Rodrigues, Pedro Pereira
AU  - Rodrigues PP
FAU - Reis, Antonio Hipolito
AU  - Reis AH
FAU - Costa-Pereira, Altamiro
AU  - Costa-Pereira A
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20101111
PL  - United States
TA  - Telemed J E Health
JT  - Telemedicine journal and e-health : the official journal of the American
      Telemedicine Association
JID - 100959949
SB  - IM
MH  - *Cardiovascular Diseases
MH  - *Defibrillators, Implantable
MH  - Humans
MH  - Monitoring, Physiologic/methods
MH  - *Telemetry
EDAT- 2010/11/13 06:00
MHDA- 2011/04/30 06:00
CRDT- 2010/11/13 06:00
PHST- 2010/11/13 06:00 [entrez]
PHST- 2010/11/13 06:00 [pubmed]
PHST- 2011/04/30 06:00 [medline]
AID - 10.1089/tmj.2010.0082 [doi]
PST - ppublish
SO  - Telemed J E Health. 2010 Dec;16(10):1042-50. doi: 10.1089/tmj.2010.0082. Epub
      2010 Nov 11.


PMID- 21070102
OWN - NLM
STAT- MEDLINE
DCOM- 20110228
LR  - 20131121
IS  - 1440-1614 (Electronic)
IS  - 0004-8674 (Linking)
VI  - 44
IP  - 12
DP  - 2010 Dec
TI  - Preventing post traumatic stress disorder: are drugs the answer?
PG  - 1064-71
LID - 10.3109/00048674.2010.509858 [doi]
AB  - In the field of traumatic stress, chemoprophylaxis is a term that is often used
      but rarely well understood. There has been no shortage of debate on the issue,
      but few rigorous studies to ground the discussion. The purpose of the current
      paper is to explore the issues surrounding this contentious area. Databases
      including PubMed, PsychArticles and Web of Knowledge were searched using the key 
      words 'chemo or pharmaco', 'prevention or prophylaxis', and 'PTSD or
      post-traumatic stress'. Relevant journals and reference lists of the papers
      obtained through this search were scanned for additional references. Studies that
      investigated the use of pharmacotherapy to prevent the onset of post-traumatic
      stress disorder were considered for this paper. Studies that examined the
      treatment of established PTSD were excluded. A total of 15 empirical studies were
      included in the review (including five randomized controlled trials), and twice
      as many non-data-driven papers. Evidence for the prophylactic use of alcohol,
      morphine, propranolol, and hydrocortisone is presented, followed by a discussion 
      of the many challenges of using pharmacological interventions in this context.
      While attention to this issue has increased in recent times, the dearth of
      empirical data has done little to further the field. Larger studies are indicated
      following small trials with medications such as propranolol and hydrocortisone.
      There remain a number of ethical and practical questions to be answered before
      the widespread use of chemoprophylaxis can be recommended.
FAU - Fletcher, Susan
AU  - Fletcher S
AD  - Australian Centre for Post-traumatic Mental Health, Department of Psychiatry,
      University of Melbourne, East Melbourne, Victoria, Australia.
      susanlf@unimelb.edu.au
FAU - Creamer, Mark
AU  - Creamer M
FAU - Forbes, David
AU  - Forbes D
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Aust N Z J Psychiatry
JT  - The Australian and New Zealand journal of psychiatry
JID - 0111052
RN  - 0 (Anti-Anxiety Agents)
RN  - 3K9958V90M (Ethanol)
RN  - 76I7G6D29C (Morphine)
RN  - 9Y8NXQ24VQ (Propranolol)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Anti-Anxiety Agents/*therapeutic use
MH  - Ethanol/therapeutic use
MH  - Humans
MH  - Hydrocortisone/therapeutic use
MH  - Morphine/therapeutic use
MH  - Propranolol/therapeutic use
MH  - Stress Disorders, Post-Traumatic/drug therapy/*prevention & control
EDAT- 2010/11/13 06:00
MHDA- 2011/03/01 06:00
CRDT- 2010/11/13 06:00
PHST- 2010/11/13 06:00 [entrez]
PHST- 2010/11/13 06:00 [pubmed]
PHST- 2011/03/01 06:00 [medline]
AID - 10.3109/00048674.2010.509858 [doi]
PST - ppublish
SO  - Aust N Z J Psychiatry. 2010 Dec;44(12):1064-71. doi:
      10.3109/00048674.2010.509858.


PMID- 21069629
OWN - NLM
STAT- MEDLINE
DCOM- 20110304
LR  - 20101111
IS  - 1439-3522 (Electronic)
IS  - 0720-4299 (Linking)
VI  - 78
IP  - 11
DP  - 2010 Nov
TI  - [Technological intervention in the self? An ethical evaluation of deep brain
      stimulation relating to patient narratives].
PG  - 644-51
LID - 10.1055/s-0029-1245753 [doi]
AB  - Technological interventions into the brain raise a number of ethical questions,
      particularly, questions of personality change and control or manipulation of the 
      human mind. Taking patients undergoing deep brain stimulation as an example, the 
      authors analyse the possible impact of neurotechnologies on human self-perception
      in individual cases as well as in general. Following the concept of
      narrative-based medicine and ethics patients' narrations are presented in order
      to discuss the value of this approach for developing normative considerations as 
      well as for deriving practical consequences regarding the
      physician-patient-relationship.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Krug, H
AU  - Krug H
AD  - Klinik und Poliklinik fur Neurologie, Charite Universitatsmedizin Berlin.
      henriette.krug@charite.de
FAU - Muller, O
AU  - Muller O
FAU - Bittner, U
AU  - Bittner U
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Technisierung des Ich? Uberlegungen zu einer ethischen Beurteilung der tiefen
      Hirnstimulation unter Verwendung von Patienten-Narrationen.
DEP - 20101110
PL  - Germany
TA  - Fortschr Neurol Psychiatr
JT  - Fortschritte der Neurologie-Psychiatrie
JID - 8103137
SB  - IM
MH  - Brain/*physiology/*radiation effects
MH  - *Deep Brain Stimulation/ethics
MH  - Humans
MH  - *Narration
MH  - Physician-Patient Relations
MH  - *Self Concept
EDAT- 2010/11/12 06:00
MHDA- 2011/03/05 06:00
CRDT- 2010/11/12 06:00
PHST- 2010/11/12 06:00 [entrez]
PHST- 2010/11/12 06:00 [pubmed]
PHST- 2011/03/05 06:00 [medline]
AID - 10.1055/s-0029-1245753 [doi]
PST - ppublish
SO  - Fortschr Neurol Psychiatr. 2010 Nov;78(11):644-51. doi: 10.1055/s-0029-1245753.
      Epub 2010 Nov 10.


PMID- 21069594
OWN - NLM
STAT- MEDLINE
DCOM- 20110303
LR  - 20101111
IS  - 1545-5815 (Electronic)
IS  - 0898-9621 (Linking)
VI  - 17
IP  - 6
DP  - 2010 Nov
TI  - "Involving interface": an extended mind theoretical approach to roboethics.
PG  - 316-29
LID - 10.1080/08989621.2010.524082 [doi]
AB  - In 2008 the authors held "Involving Interface," a lively interdisciplinary event 
      focusing on issues of biological, sociocultural, and technological interfacing
      (see Acknowledgments). Inspired by discussions at this event, in this article, we
      further discuss the value of input from neuroscience for developing robots and
      machine interfaces, and the value of philosophy, the humanities, and the arts for
      identifying persistent links between human interfacing and broader ethical
      concerns. The importance of ongoing interdisciplinary debate and public
      communication on scientific and technical advances is also highlighted.
      Throughout, the authors explore the implications of the extended mind hypothesis 
      for notions of moral accountability and robotics.
FAU - Anderson, Miranda
AU  - Anderson M
AD  - Department of English Literature, University of Edinburgh, Edinburgh, UK.
FAU - Ishiguro, Hiroshi
AU  - Ishiguro H
FAU - Fukushi, Tamami
AU  - Fukushi T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Account Res
JT  - Accountability in research
JID - 9100813
SB  - IM
MH  - Ethical Theory
MH  - Humans
MH  - Interdisciplinary Communication
MH  - *Man-Machine Systems
MH  - *Mental Processes
MH  - Neurosciences/*ethics/trends
MH  - Personhood
MH  - Robotics/*ethics/trends
MH  - Technology Assessment, Biomedical
EDAT- 2010/11/12 06:00
MHDA- 2011/03/04 06:00
CRDT- 2010/11/12 06:00
PHST- 2010/11/12 06:00 [entrez]
PHST- 2010/11/12 06:00 [pubmed]
PHST- 2011/03/04 06:00 [medline]
AID - 929385409 [pii]
AID - 10.1080/08989621.2010.524082 [doi]
PST - ppublish
SO  - Account Res. 2010 Nov;17(6):316-29. doi: 10.1080/08989621.2010.524082.


PMID- 21069593
OWN - NLM
STAT- MEDLINE
DCOM- 20110303
LR  - 20101111
IS  - 1545-5815 (Electronic)
IS  - 0898-9621 (Linking)
VI  - 17
IP  - 6
DP  - 2010 Nov
TI  - Beyond speculative robot ethics: a vision assessment study on the future of the
      robotic caretaker.
PG  - 299-315
LID - 10.1080/08989621.2010.524078 [doi]
AB  - In this article we develop a dialogue model for robot technology experts and
      designated users to discuss visions on the future of robotics in long-term care. 
      Our vision assessment study aims for more distinguished and more informed visions
      on future robots. Surprisingly, our experiment also led to some promising
      co-designed robot concepts in which jointly articulated moral guidelines are
      embedded. With our model, we think to have designed an interesting response on a 
      recent call for a less speculative ethics of technology by encouraging
      discussions about the quality of positive and negative visions on the future of
      robotics.
FAU - van der Plas, Arjanna
AU  - van der Plas A
AD  - TNO Information and Communication Technology, Delft, The Netherlands.
FAU - Smits, Martijntje
AU  - Smits M
FAU - Wehrmann, Caroline
AU  - Wehrmann C
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Account Res
JT  - Accountability in research
JID - 9100813
SB  - IM
MH  - Attitude of Health Personnel
MH  - Attitude to Health
MH  - Caregivers
MH  - Forecasting
MH  - Humans
MH  - Independent Living
MH  - Long-Term Care/ethics/*methods
MH  - Robotics/*ethics/trends
MH  - Social Behavior
MH  - Technology Assessment, Biomedical/*methods
EDAT- 2010/11/12 06:00
MHDA- 2011/03/04 06:00
CRDT- 2010/11/12 06:00
PHST- 2010/11/12 06:00 [entrez]
PHST- 2010/11/12 06:00 [pubmed]
PHST- 2011/03/04 06:00 [medline]
AID - 929385493 [pii]
AID - 10.1080/08989621.2010.524078 [doi]
PST - ppublish
SO  - Account Res. 2010 Nov;17(6):299-315. doi: 10.1080/08989621.2010.524078.


PMID- 21069591
OWN - NLM
STAT- MEDLINE
DCOM- 20110303
LR  - 20101111
IS  - 1545-5815 (Electronic)
IS  - 0898-9621 (Linking)
VI  - 17
IP  - 6
DP  - 2010 Nov
TI  - Introduction: roboethics as an emerging field of ethics of technology.
PG  - 273-7
LID - 10.1080/08989621.2010.523672 [doi]
FAU - Ishihara, Kohji
AU  - Ishihara K
AD  - Graduate School of Arts and Sciences, University of Tokyo, Tokyo, Japan.
      cishi08@mail.ecc.u-tokyo.ac.jp
FAU - Fukushi, Tamami
AU  - Fukushi T
LA  - eng
PT  - Introductory Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Account Res
JT  - Accountability in research
JID - 9100813
SB  - IM
MH  - Biomedical Technology/*ethics
MH  - Ethics, Research
MH  - Humans
MH  - Robotics/*ethics
EDAT- 2010/11/12 06:00
MHDA- 2011/03/04 06:00
CRDT- 2010/11/12 06:00
PHST- 2010/11/12 06:00 [entrez]
PHST- 2010/11/12 06:00 [pubmed]
PHST- 2011/03/04 06:00 [medline]
AID - 929385474 [pii]
AID - 10.1080/08989621.2010.523672 [doi]
PST - ppublish
SO  - Account Res. 2010 Nov;17(6):273-7. doi: 10.1080/08989621.2010.523672.


PMID- 21068553
OWN - NLM
STAT- MEDLINE
DCOM- 20110315
LR  - 20101111
IS  - 1550-5014 (Electronic)
IS  - 0161-9268 (Linking)
VI  - 33
IP  - 4
DP  - 2010 Oct-Dec
TI  - The essential imperative of basic nursing education: an ethical discourse.
PG  - 320-8
LID - 10.1097/ANS.0b013e3181fb2eba [doi]
AB  - The presence of multiple educational pathways into professional nursing is not
      without ethical consequences. If the essential duty of nursing is to the patient 
      then education must focus on teaching the highest provision of patient care. The 
      humanities component of the baccalaureate provides both insight into the human
      condition and exposure to alternate problem-solving methodologies, both of which 
      augment the nursing process and improve patient care. An argument is made that by
      not requiring more rather than less education, we ultimately fail the patient and
      thus, our ethical duty.
FAU - Peirce, Anne Griswold
AU  - Peirce AG
AD  - School of Nursing, Adelphi University, One South Avenue, Garden City, New York
      11530, USA. peirce@adelphi.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - ANS Adv Nurs Sci
JT  - ANS. Advances in nursing science
JID - 7809992
SB  - IM
MH  - Education, Nursing/*ethics
MH  - Education, Nursing, Baccalaureate
MH  - Humanities/education
MH  - Humans
MH  - Nurse's Role
MH  - Nurse-Patient Relations/*ethics
MH  - Philosophy, Nursing
MH  - United States
EDAT- 2010/11/12 06:00
MHDA- 2011/03/16 06:00
CRDT- 2010/11/12 06:00
PHST- 2010/11/12 06:00 [entrez]
PHST- 2010/11/12 06:00 [pubmed]
PHST- 2011/03/16 06:00 [medline]
AID - 10.1097/ANS.0b013e3181fb2eba [doi]
AID - 00012272-201010000-00006 [pii]
PST - ppublish
SO  - ANS Adv Nurs Sci. 2010 Oct-Dec;33(4):320-8. doi: 10.1097/ANS.0b013e3181fb2eba.


PMID- 21068075
OWN - NLM
STAT- MEDLINE
DCOM- 20110125
LR  - 20211203
IS  - 1468-2052 (Electronic)
IS  - 1359-2998 (Linking)
VI  - 96
IP  - 1
DP  - 2011 Jan
TI  - Ethical and practical issues relating to the global use of therapeutic
      hypothermia for perinatal asphyxial encephalopathy.
PG  - F75-8
LID - 10.1136/adc.2010.184689 [doi]
AB  - In intensive care settings in the developed world, therapeutic hypothermia is
      established as a therapy for term infants with moderate to severe neonatal
      encephalopathy due to perinatal asphyxia. Several preclinical, pilot and clinical
      trials conducted in such settings over the last decade have demonstrated that
      this therapy is safe and effective. The greatest burden of birth asphyxia falls, 
      however, in low- and middle-income countries; it is still unclear whether
      therapeutic hypothermia is safe and effective in this context. In this paper, the
      issues around treatments that may be proven safe and effective in the developed
      world and the caution needed in translating these into different settings and
      populations are explored. It is argued that there are strong scientific and
      ethical reasons supporting the conduct of rigorous, randomised controlled trials 
      of therapeutic hypothermia in middle-income settings. There also needs to be
      substantial and sustainable improvements in all facets of antenatal care and in
      the basic level of newborn resuscitation in low income countries. This will
      reduce the burden of disease and allow health workers to determine rapidly which 
      infants are most eligible for potential neuroprotection.
FAU - Wilkinson, D J
AU  - Wilkinson DJ
AD  - The Ethox Centre, Department of Public Health and Primary Health Care, The
      University of Oxford, Headington, Oxford, UK. dominic.wilkinson@ethox.ox.ac.uk
FAU - Thayyil, S
AU  - Thayyil S
FAU - Robertson, N J
AU  - Robertson NJ
LA  - eng
GR  - NIHR/CS/010/022/DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101110
PL  - England
TA  - Arch Dis Child Fetal Neonatal Ed
JT  - Archives of disease in childhood. Fetal and neonatal edition
JID - 9501297
SB  - IM
MH  - Asphyxia Neonatorum/complications
MH  - *Developing Countries
MH  - Developmental Disabilities/prevention & control
MH  - Ethics, Medical
MH  - Humans
MH  - Hypothermia, Induced/*ethics
MH  - Hypoxia-Ischemia, Brain/etiology/*therapy
MH  - Infant, Newborn
MH  - Perinatal Care/*ethics/methods
MH  - Translational Research, Biomedical
EDAT- 2010/11/12 06:00
MHDA- 2011/01/28 06:00
CRDT- 2010/11/12 06:00
PHST- 2010/11/12 06:00 [entrez]
PHST- 2010/11/12 06:00 [pubmed]
PHST- 2011/01/28 06:00 [medline]
AID - adc.2010.184689 [pii]
AID - 10.1136/adc.2010.184689 [doi]
PST - ppublish
SO  - Arch Dis Child Fetal Neonatal Ed. 2011 Jan;96(1):F75-8. doi:
      10.1136/adc.2010.184689. Epub 2010 Nov 10.


PMID- 21068015
OWN - NLM
STAT- MEDLINE
DCOM- 20110722
LR  - 20110331
IS  - 1742-3406 (Electronic)
IS  - 0144-8420 (Linking)
VI  - 144
IP  - 1-4
DP  - 2011 Mar
TI  - Ethical issues related to professional exposure of pregnant women in the medical 
      field: monitoring and limiting effective dose.
PG  - 525-9
LID - 10.1093/rpd/ncq352 [doi]
AB  - The International Commission on Radiological Protection recommendations for
      occupational exposed pregnant women do not imply necessarily the complete
      avoidance of work with radiation or radioactive materials. Instead, a careful
      review of the exposure conditions, once the pregnancy is declared, as part of the
      exercise of the ICRP optimisation principle (based in a teleological ethics point
      of view) is suggested. The dose limitation (following a deontological ethics
      point of view) of the fetus/embryo is, however, not clearly well established as
      happens in the case of workers or members of the public. Also, the justification 
      of practices (to continue to work or not with radiation or radioactive materials)
      is not clearly addressed in most national or international recommendations. An
      analysis of this justification (bearing in mind both teleological and
      deontological ethics) is examined in this work having in mind the best interest
      of the child-to-be as well as other existing social and economical factors.
FAU - Santos, J A M
AU  - Santos JA
AD  - Servico de Fisica Medica, Instituto Portugues de Oncologia do Porto, EPE, Rua Dr 
      Antonio Bernardino de Almeida, 4200-072 Porto, Portugal.
      j.a.miranda.santos@gmail.com
FAU - Nunes, R
AU  - Nunes R
LA  - eng
PT  - Journal Article
DEP - 20101109
PL  - England
TA  - Radiat Prot Dosimetry
JT  - Radiation protection dosimetry
JID - 8109958
SB  - IM
MH  - Environmental Exposure
MH  - Ethics, Medical
MH  - Female
MH  - Gamma Rays
MH  - Humans
MH  - Informed Consent
MH  - International Cooperation
MH  - Maternal Exposure
MH  - Occupational Exposure/*prevention & control
MH  - Pregnancy
MH  - Pregnant Women
MH  - Radiation Dosage
MH  - Radiation Monitoring/ethics
MH  - Radiation Protection/*methods/standards
MH  - Risk
MH  - X-Rays
EDAT- 2010/11/12 06:00
MHDA- 2011/07/23 06:00
CRDT- 2010/11/12 06:00
PHST- 2010/11/12 06:00 [entrez]
PHST- 2010/11/12 06:00 [pubmed]
PHST- 2011/07/23 06:00 [medline]
AID - ncq352 [pii]
AID - 10.1093/rpd/ncq352 [doi]
PST - ppublish
SO  - Radiat Prot Dosimetry. 2011 Mar;144(1-4):525-9. doi: 10.1093/rpd/ncq352. Epub
      2010 Nov 9.


PMID- 21067967
OWN - NLM
STAT- MEDLINE
DCOM- 20110517
LR  - 20141120
IS  - 1872-8243 (Electronic)
IS  - 1386-5056 (Linking)
VI  - 80
IP  - 2
DP  - 2011 Feb
TI  - Ethical and legal challenges for health telematics in a global world: telehealth 
      and the technological imperative.
PG  - e1-5
LID - 10.1016/j.ijmedinf.2010.10.002 [doi]
AB  - Telehealth is one of the more recent applications of ICT to health care. It
      promises to be both cost-effective and efficient. However, there lies a danger
      that focusing mainly on pragmatic considerations will ignore fundamental ethical 
      issues with legal implications that could undermine its success. Implicated here 
      are, among others, changes in the nature of the health care professional patient 
      relationship and informed consent, etc. The position of health informatics
      professionals as well as hard- and software providers is also affected. A further
      complicating factor is outsourcing. This paper identifies relevant issues and
      outlines some of their implications.
CI  - Copyright A(c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Kluge, Eike-Henner W
AU  - Kluge EH
AD  - Department of Philosophy, University of Victoria and WG4 (IMIA), Canada.
      ekluge@uvic.ca
LA  - eng
PT  - Journal Article
DEP - 20101109
PL  - Ireland
TA  - Int J Med Inform
JT  - International journal of medical informatics
JID - 9711057
SB  - IM
MH  - Confidentiality/legislation & jurisprudence
MH  - *Delivery of Health Care
MH  - Global Health
MH  - Humans
MH  - Informed Consent/legislation & jurisprudence
MH  - Technology/*ethics/*legislation & jurisprudence
MH  - Telemedicine/*ethics/*legislation & jurisprudence
EDAT- 2010/11/12 06:00
MHDA- 2011/05/18 06:00
CRDT- 2010/11/12 06:00
PHST- 2010/07/26 00:00 [received]
PHST- 2010/10/02 00:00 [accepted]
PHST- 2010/11/12 06:00 [entrez]
PHST- 2010/11/12 06:00 [pubmed]
PHST- 2011/05/18 06:00 [medline]
AID - S1386-5056(10)00173-5 [pii]
AID - 10.1016/j.ijmedinf.2010.10.002 [doi]
PST - ppublish
SO  - Int J Med Inform. 2011 Feb;80(2):e1-5. doi: 10.1016/j.ijmedinf.2010.10.002. Epub 
      2010 Nov 9.


PMID- 21067554
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20211020
IS  - 1466-609X (Electronic)
IS  - 1364-8535 (Linking)
VI  - 14
IP  - 5
DP  - 2010
TI  - Withholding selective decontamination of the digestive tract from critically ill 
      patients must now surely be ethically questionable given the vast evidence base.
PG  - 443
LID - 10.1186/cc9255 [doi]
FAU - Zandstra, Durk F
AU  - Zandstra DF
FAU - Petros, Andy J
AU  - Petros AJ
FAU - Taylor, Nia
AU  - Taylor N
FAU - Silvestri, Luciano
AU  - Silvestri L
FAU - de la Cal, Miguel A
AU  - de la Cal MA
FAU - van Saene, Hendrick K F
AU  - van Saene HK
LA  - eng
PT  - Comment
PT  - Letter
DEP - 20101006
PL  - England
TA  - Crit Care
JT  - Critical care (London, England)
JID - 9801902
SB  - IM
CON - Crit Care. 2010;14(3):314. PMID: 20587083
MH  - Critical Illness
MH  - Decontamination/*ethics
MH  - Evidence-Based Medicine/*ethics
MH  - Gastrointestinal Tract/*microbiology
MH  - Humans
MH  - Withholding Treatment/*ethics
PMC - PMC3219259
EDAT- 2010/11/12 06:00
MHDA- 2011/10/01 06:00
CRDT- 2010/11/12 06:00
PHST- 2010/11/12 06:00 [entrez]
PHST- 2010/11/12 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - cc9255 [pii]
AID - 10.1186/cc9255 [doi]
PST - ppublish
SO  - Crit Care. 2010;14(5):443. doi: 10.1186/cc9255. Epub 2010 Oct 6.


PMID- 21063994
OWN - NLM
STAT- MEDLINE
DCOM- 20120410
LR  - 20211203
IS  - 0374-9096 (Print)
IS  - 0374-9096 (Linking)
VI  - 44
IP  - 3
DP  - 2010 Jul
TI  - [Comparison of glucan and galactomannan tests with real-time PCR for diagnosis of
      invasive aspergillosis in a neutropenic rat model].
PG  - 441-52
AB  - The incidence of aspergillosis which has high mortality rates, has increased
      gradually. Since invasive aspergillosis (IA) is one of the leading causes of
      death in immunocompromized and neutropenic patients, early and accurate diagnosis
      of IA is of crucial importance. The aims of this study were to compare the
      results of culture, real-time polymerase chain reaction (RtPCR), galactomannan
      (GM) antigen and glucan (GC) antigen detection tests and to evaluate their
      performances in view of rapid and accurate diagnosis of IA in neutropenic rat
      model. Female Wistar albino rats were included in the study with the consent of
      Animal Searching Ethical Committee and classified into three groups as healthy
      controls (n= 6), neutropenic controls (n= 10) and pulmonary aspergillosis (n= 35)
      groups. Rats were immunosuppressed with 5-flourourasil and then Aspergillus
      fumigatus conidia were inoculated intranasally. On the seventh day of the
      infection, blood, bronchoalveolar lavage (BAL) and lung tissue samples were
      collected from the animals, and control and aspergillosis groups were compared in
      terms of infection markers. All of the tests (culture, RtPCR, GM and BG tests)
      were found to be negative in controls. At the end of the study 22 rats in
      aspergillosis group survived. Lung tissue samples from those 22 animals were all 
      positive for the presence of hypha on pathological preparations, while 20 (91%)
      yielded Aspergillus colonies on the cultures. Aspergillus DNA was detected in 7
      of the 12 BAL samples (58.3%), 7 of 19 blood samples (36.8%) and 4 of 22 lung
      tissue samples (18%) using RtPCR method. GM antigen was detected in 7 of 20 serum
      samples (35%) with a commercial kit (Platelia(R) Aspergillus ELISA, BioRad,
      France). Quantitative detection of betalucan levels were investigated by using a 
      commercial kit (Fungitell, Cape Cod, USA) in serum and BAL samples and positive
      results were obtained in 11 of 22 serum (50%) and 9 of 17 BAL (52.9%) samples. In
      this study it was demonstrated that PCR performed in BAL samples is the most
      sensitive method compared to the others, for the diagnosis of IA in the rat
      model. The sensitivity rates were as follows when culture method accepted as the 
      gold standard: 58.3% for BAL-PCR, 41.2% for blood-PCR, 20% for tissue-PCR, 38.9% 
      for serum GM, 55% for serum GC and 52.9% for BAL-GC. It was also concluded that
      detection of GC activity in serum was more sensitive than GM detection in serum
      (sensitivity of GM was %38.9, sensitivity of GC was %55, while specificities were
      100% for both of the tests), for laboratory diagnosis of IA. The BAL samples were
      evaluated as the most valuable clinical samples to screen the suspected patients.
      However, even in proven cases, 41.7% of BAL samples were found negative with PCR,
      50% of serum samples were found negative with GC test, and 65% of serum samples
      were found negative with GM test. Since the pathogenesis of IA has not been
      completely clarified, the performance of non-culture based diagnostic tests
      exhibit great variability. Future clinical studies are required to compare the
      performance of different nonculture based diagnostic methods and the optimal
      combination of these tests for the most accurate laboratory diagnosis of IA.
FAU - Aydogan, Sibel
AU  - Aydogan S
AD  - Hacettepe Universitesi Tip Fakultesi, Tibbi Mikrobiyoloji Anabilim Dali, Ankara, 
      Turkiye. drsibay@mynet.com
FAU - Kustimur, Semra
AU  - Kustimur S
FAU - Kalkanci, Ayse
AU  - Kalkanci A
LA  - tur
PT  - Comparative Study
PT  - Journal Article
TT  - Invazif aspergilloz olusturulan sicanlarda glukan ve galaktomannan testleri ile
      gercek zamanli polimeraz zincir reaksiyonu sonuclarinin karsilastirilmasi
PL  - Turkey
TA  - Mikrobiyol Bul
JT  - Mikrobiyoloji bulteni
JID - 7503830
RN  - 0 (Antigens, Fungal)
RN  - 0 (DNA, Fungal)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Mannans)
RN  - 0 (beta-Glucans)
RN  - 11078-30-1 (galactomannan)
RN  - U3P01618RT (Fluorouracil)
RN  - X2RN3Q8DNE (Galactose)
SB  - IM
MH  - Animals
MH  - Antigens, Fungal/blood/immunology
MH  - Aspergillus fumigatus/genetics/immunology/*isolation & purification
MH  - Bronchoalveolar Lavage Fluid/microbiology
MH  - DNA, Fungal/isolation & purification
MH  - Disease Models, Animal
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Fluorouracil/administration & dosage
MH  - Galactose/analogs & derivatives
MH  - Immunosuppression Therapy
MH  - Immunosuppressive Agents/administration & dosage
MH  - Invasive Pulmonary Aspergillosis/*diagnosis
MH  - Lung/microbiology
MH  - Mannans/*blood/immunology
MH  - Neutropenia/complications
MH  - Rats
MH  - Rats, Wistar
MH  - Real-Time Polymerase Chain Reaction
MH  - Sensitivity and Specificity
MH  - beta-Glucans/*blood/immunology
EDAT- 2010/11/11 06:00
MHDA- 2012/04/11 06:00
CRDT- 2010/11/11 06:00
PHST- 2010/11/11 06:00 [entrez]
PHST- 2010/11/11 06:00 [pubmed]
PHST- 2012/04/11 06:00 [medline]
PST - ppublish
SO  - Mikrobiyol Bul. 2010 Jul;44(3):441-52.


PMID- 21063801
OWN - NLM
STAT- MEDLINE
DCOM- 20110701
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 16
IP  - 4
DP  - 2010 Dec
TI  - Statistical power, the Belmont report, and the ethics of clinical trials.
PG  - 675-91
LID - 10.1007/s11948-010-9244-0 [doi]
AB  - Achieving a good clinical trial design increases the likelihood that a trial will
      take place as planned, including that data will be obtained from a sufficient
      number of participants, and the total number of participants will be the minimal 
      required to gain the knowledge sought. A good trial design also increases the
      likelihood that the knowledge sought by the experiment will be forthcoming.
      Achieving such a design is more than good sense-it is ethically required in
      experiments when participants are at risk of harm. This paper argues that doing a
      power analysis effectively contributes to ensuring that a trial design is good.
      The ethical importance of good trial design has long been recognized for trials
      in which there is risk of serious harm to participants. However, whether the
      quality of a trial design, when the risk to participants is only minimal, is an
      ethical issue is rarely discussed. This paper argues that even in cases when the 
      risk is minimal, the quality of the trial design is an ethical issue, and that
      this is reflected in the emphasis the Belmont Report places on the importance of 
      the benefit of knowledge gained by society. The paper also argues that good trial
      design is required for true informed consent.
FAU - Vollmer, Sara H
AU  - Vollmer SH
AD  - Department of Philosophy, UAB Center for Ethics and Values in the Sciences, 900
      13th St South, 414A, Birmingham, AL 35294-1260, USA. vollmer@uab.edu
FAU - Howard, George
AU  - Howard G
LA  - eng
PT  - Historical Article
PT  - Journal Article
DEP - 20101110
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
CIN - Sci Eng Ethics. 2010 Dec;16(4):693-6. PMID: 21103950
MH  - Clinical Trials as Topic/*ethics/history/standards
MH  - *Ethics, Research/history
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Human Experimentation/*ethics/history/standards
MH  - Humans
MH  - *Informed Consent/history
MH  - Patient Selection/*ethics
MH  - Research Design/*standards
MH  - Risk
MH  - Safety
MH  - Statistics as Topic
EDAT- 2010/11/11 06:00
MHDA- 2011/07/02 06:00
CRDT- 2010/11/11 06:00
PHST- 2007/08/15 00:00 [received]
PHST- 2010/10/04 00:00 [accepted]
PHST- 2010/11/11 06:00 [entrez]
PHST- 2010/11/11 06:00 [pubmed]
PHST- 2011/07/02 06:00 [medline]
AID - 10.1007/s11948-010-9244-0 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2010 Dec;16(4):675-91. doi: 10.1007/s11948-010-9244-0. Epub 2010 
      Nov 10.


PMID- 21063651
OWN - NLM
STAT- MEDLINE
DCOM- 20110301
LR  - 20110826
IS  - 0379-5284 (Print)
IS  - 0379-5284 (Linking)
VI  - 31
IP  - 11
DP  - 2010 Nov
TI  - Kawasaki disease in Western Saudi Arabia.
PG  - 1217-20
AB  - OBJECTIVE: To describe our experience on Kawasaki disease in the Madinah region, 
      Kingdom of Saudi Arabia (KSA). METHODS: This is a retrospective hospital based
      study. The study was conducted in Maternity and Children Hospital, Madinah,
      Kingdom of Saudi Arabia during January 2007 to January 2010. The study included
      51 patients' records as suspected cases of Kawasaki disease. The study was
      approved by the Ethical Committee. RESULTS: Twenty-four patients were proven to
      have Kawasaki disease in this study. The mean age of the patients at diagnosis
      was 3.1+/-2.4 years. Most patients were younger than 5 years (83.3%). The male to
      female ratio was 1.7:1. Diagnosis was made 8.1+/-3.3 days after start of fever
      with a range from 4-15 days. All patients received intravenous immunoglobulin
      (IVIG) with 2 requiring another dose of IVIG. Echocardiography was performed
      10.1+/-3.9 days from onset of fever with a range of 4-20 days. The duration of
      hospital stay was 7.9+/-5.8 days with a range from 3-25 days. Three patients had 
      coronary artery abnormalities and still have coronary artery dilatation at last
      follow-up appointment. CONCLUSION: A high index of suspicion is mandatory for
      early diagnosis of Kawasaki disease as delayed diagnosis may lead to coronary
      lesions. A national awareness program on Kawasaki disease is recommended.
FAU - Al-Harbi, Khalid M
AU  - Al-Harbi KM
AD  - Department of Pediatrics and Pediatrics Cardiology, Faculty of Medicine, Taibah
      University, Madinah, Kingdom of Saudi Arabia. kharbi@windowslive.com
LA  - eng
PT  - Journal Article
PL  - Saudi Arabia
TA  - Saudi Med J
JT  - Saudi medical journal
JID - 7909441
SB  - IM
CIN - Saudi Med J. 2011 Jul;32(7):749. PMID: 21748220
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Mucocutaneous Lymph Node Syndrome/diagnosis/*epidemiology
MH  - Retrospective Studies
MH  - Saudi Arabia/epidemiology
EDAT- 2010/11/11 06:00
MHDA- 2011/03/02 06:00
CRDT- 2010/11/11 06:00
PHST- 2010/11/11 06:00 [entrez]
PHST- 2010/11/11 06:00 [pubmed]
PHST- 2011/03/02 06:00 [medline]
AID - 20102889' [pii]
PST - ppublish
SO  - Saudi Med J. 2010 Nov;31(11):1217-20.


PMID- 21063557
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20220427
IS  - 0974-519X (Electronic)
IS  - 0974-2700 (Linking)
VI  - 3
IP  - 4
DP  - 2010 Oct
TI  - Simulation-based learning: Just like the real thing.
PG  - 348-52
LID - 10.4103/0974-2700.70743 [doi]
AB  - Simulation is a technique for practice and learning that can be applied to many
      different disciplines and trainees. It is a technique (not a technology) to
      replace and amplify real experiences with guided ones, often "immersive" in
      nature, that evoke or replicate substantial aspects of the real world in a fully 
      interactive fashion. Simulation-based learning can be the way to develop health
      professionals' knowledge, skills, and attitudes, whilst protecting patients from 
      unnecessary risks. Simulation-based medical education can be a platform which
      provides a valuable tool in learning to mitigate ethical tensions and resolve
      practical dilemmas. Simulation-based training techniques, tools, and strategies
      can be applied in designing structured learning experiences, as well as be used
      as a measurement tool linked to targeted teamwork competencies and learning
      objectives. It has been widely applied in fields such aviation and the military. 
      In medicine, simulation offers good scope for training of interdisciplinary
      medical teams. The realistic scenarios and equipment allows for retraining and
      practice till one can master the procedure or skill. An increasing number of
      health care institutions and medical schools are now turning to simulation-based 
      learning. Teamwork training conducted in the simulated environment may offer an
      additive benefit to the traditional didactic instruction, enhance performance,
      and possibly also help reduce errors.
FAU - Lateef, Fatimah
AU  - Lateef F
AD  - Senior Consultant, Director of Training and Education, Department of Emergency
      Medicine, Singapore General Hospital, Singapore.
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Emerg Trauma Shock
JT  - Journal of emergencies, trauma, and shock
JID - 101493921
PMC - PMC2966567
OTO - NOTNLM
OT  - Simulation
OT  - learning
OT  - medical education
OT  - virtual reality
EDAT- 2010/11/11 06:00
MHDA- 2010/11/11 06:01
CRDT- 2010/11/11 06:00
PHST- 2009/01/27 00:00 [received]
PHST- 2009/11/14 00:00 [accepted]
PHST- 2010/11/11 06:00 [entrez]
PHST- 2010/11/11 06:00 [pubmed]
PHST- 2010/11/11 06:01 [medline]
AID - 10.4103/0974-2700.70743 [doi]
PST - ppublish
SO  - J Emerg Trauma Shock. 2010 Oct;3(4):348-52. doi: 10.4103/0974-2700.70743.


PMID- 21063543
OWN - NLM
STAT- MEDLINE
DCOM- 20110321
LR  - 20211020
IS  - 1559-4122 (Electronic)
IS  - 1559-4122 (Linking)
VI  - 7
DP  - 2010 Oct 1
TI  - Adding a genomic healthcare component to a health information management
      curriculum.
PG  - 1b
AB  - The inclusion of genomic information will become routine in electronic health
      records (EHRs). Educating health information management (HIM) students about how 
      to best manage, protect, properly release, and use this information for patient
      care is of utmost importance. This study examined the usefulness of incorporating
      genomic modules into an existing course in quality management. Pretest and
      posttest results showed that students improved in all areas related to genomics
      in healthcare. Also, students enjoyed the class scenarios and discussion on the
      ethical use of genomic information. Interspersing genomic information management 
      throughout an existing quality management class is an effective way to add this
      information to an existing HIM curriculum.
FAU - Ludwig, Bailee
AU  - Ludwig B
AD  - University of Pittsburgh in Pittsburgh, PA, USA.
FAU - Zhou, Leming
AU  - Zhou L
FAU - Watzlaf, Valerie
AU  - Watzlaf V
FAU - Abdelhak, Mervat
AU  - Abdelhak M
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20101001
PL  - United States
TA  - Perspect Health Inf Manag
JT  - Perspectives in health information management
JID - 101219871
SB  - IM
MH  - *Curriculum
MH  - Data Collection
MH  - *Delivery of Health Care
MH  - Electronic Health Records/*trends
MH  - Genomics/*education
MH  - Humans
MH  - Information Management/*education
MH  - Pennsylvania
MH  - Quality Control
PMC - PMC2966353
OTO - NOTNLM
OT  - education
OT  - genomic information
OT  - pretest-posttest study
OT  - quality management
EDAT- 2010/11/11 06:00
MHDA- 2011/03/22 06:00
CRDT- 2010/11/11 06:00
PHST- 2010/11/11 06:00 [entrez]
PHST- 2010/11/11 06:00 [pubmed]
PHST- 2011/03/22 06:00 [medline]
PST - epublish
SO  - Perspect Health Inf Manag. 2010 Oct 1;7:1b.


PMID- 21063047
OWN - NLM
STAT- MEDLINE
DCOM- 20110331
LR  - 20101110
IS  - 0125-9326 (Print)
IS  - 0125-9326 (Linking)
VI  - 42
IP  - 4
DP  - 2010 Oct
TI  - Clinical applications of stem cell therapy for regenerating the heart.
PG  - 243-57
AB  - An immediate reperfusion therapy after acute myocardial infarction (AMI) is a
      prerequisite to prevent further cardiac damage and minimize ventricular
      remodelling. Although a rigorous and sophisticated set of therapeutic procedure
      has been applied in the disease management, mortality rate has yet unchanged
      during the last twenty years. This fact necessitates an alternative or adjuvant
      therapy that is critically safe and capable of repairing the injured vascular as 
      well as regenerating the infarcted myocardium without omitting the ethical
      considerations. Stem cell therapy could be the answer. It has gained major basic 
      and clinical research interest, ever since its discovered potential to repair the
      injured vascular in 1997. Multiple cell types across lineages have been shown to 
      be able to transdifferentiate into mature functioning cardiomyocytes either in
      vitro through similar phenotypical and genotypical characteristics or in vivo by 
      regenerating the infarcted myocardium and improve contractile function. Although 
      the exact repairing mechanisms are still in a major debate, numerous clinical
      trials have demonstrated favorable effects toward the use of autologous stem
      cells in AMI patients with considerably low side effects. Despite the relatively 
      novel discovery, stem cell therapy offers a promising prospect to confer a better
      protection, prevent later complications, and perhaps reduce the mortality among
      patients with ischemic heart disease. This ultimate outcome would likely be
      achieved through a stringent and coordinated of either basic and clinical
      research.
FAU - Soejitno, Andreas
AU  - Soejitno A
AD  - Faculty of Medicine, Udayana University. Jl. PB. Sudirman, Denpasar 80232, Bali, 
      Indonesia. andreas.soejitno@live
FAU - Wihandani, Desak M
AU  - Wihandani DM
FAU - Kuswardhani, R A Tuty
AU  - Kuswardhani RA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Indonesia
TA  - Acta Med Indones
JT  - Acta medica Indonesiana
JID - 7901042
SB  - IM
MH  - Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Myoblasts, Skeletal
MH  - Myocardial Infarction/pathology/*therapy
MH  - Myocardium/*cytology/pathology
MH  - Myocytes, Cardiac
MH  - Pluripotent Stem Cells
EDAT- 2010/11/11 06:00
MHDA- 2011/04/01 06:00
CRDT- 2010/11/11 06:00
PHST- 2010/11/11 06:00 [entrez]
PHST- 2010/11/11 06:00 [pubmed]
PHST- 2011/04/01 06:00 [medline]
AID - 040579197 [pii]
PST - ppublish
SO  - Acta Med Indones. 2010 Oct;42(4):243-57.


PMID- 21062922
OWN - NLM
STAT- MEDLINE
DCOM- 20110317
LR  - 20220330
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 258
IP  - 2
DP  - 2011 Feb
TI  - PET/CT characteristics of isolated bone metastases in hepatocellular carcinoma.
PG  - 515-23
LID - 10.1148/radiol.10100672 [doi]
AB  - PURPOSE: To compare the prognostic implications and positron emission tomography 
      (PET)/computed tomography (CT) characteristics of isolated bone metastasis
      secondary to hepatocellular carcinoma (HCC) with those of HCC metastases to bone 
      and other sites. MATERIALS AND METHODS: This study was approved by the
      institutional ethics committee, and informed consent was obtained from all
      patients. Extrahepatic metastases were diagnosed in 257 patients with HCC by
      using dual-tracer (carbon 11 [(11)C] acetate and fluorine 18 fluorodeoxyglucose
      [FDG]) PET/CT. Metastatic bone lesions were identified with visual inspection and
      semiquantitative assessment and confirmed with histopathologic examination and/or
      supported by findings at other radiologic examinations or serial PET/CT. RESULTS:
      The frequency of bone metastasis from HCC was 19% (49 of 257 patients; eight
      patients had histopathologic proof and 41 had imaging proof). Metastasis isolated
      to bone (group 1, 30 of 257 patients [12%]) was more common than metastasis to
      bone and other sites (group 2, 19 of 257 patients [7%]). At lesion-based analysis
      of group 1 (71 index lesions; mean lesion size +/- standard deviation, 3.25 cm
      +/- 1.88), (11)C acetate PET was more sensitive than FDG PET (93% [66 of 71
      lesions] vs 62% [44 of 71 lesions], respectively; P < .05). The combined
      sensitivity was 97% (69 of 71 lesions) with dual-tracer PET and 72% (51 of 71
      lesions) with CT. At patient-based analysis, (11)C acetate PET had an incremental
      value of 23% (seven of 30 patients) over FDG PET. At lesion-based analysis of
      group 2, FDG PET was more sensitive than (11)C acetate PET (87% [33 of 38
      lesions] vs 50% [19 of 38 lesions], respectively; P < .05). Tracer avidities of
      metastatic bone lesions were closely correlated with that of their corresponding 
      primary HCC tumors. The median survival time was longer in group 1 than in group 
      2 (18 months vs 11 months, respectively; P < .05). CONCLUSION: Isolated bone
      metastasis from HCC may not be as uncommon as previously believed. The detection 
      of these metastases can be significantly enhanced with (11)C acetate PET compared
      with FDG PET alone. Identification of this group of patients also seems to have
      prognostic importance.
CI  - (c) RSNA, 2010.
FAU - Ho, Chi-Lai
AU  - Ho CL
AD  - Department of Nuclear Medicine & PET, Hong Kong Sanatorium & Hospital, 2 Village 
      Rd, Happy Valley, Hong Kong SAR, China.
FAU - Chen, Sirong
AU  - Chen S
FAU - Cheng, Thomas Kam Chau
AU  - Cheng TK
FAU - Leung, Yim Lung
AU  - Leung YL
LA  - eng
PT  - Journal Article
DEP - 20101109
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Acetates)
RN  - 0 (Radiopharmaceuticals)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
SB  - IM
MH  - Acetates
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Bone Neoplasms/*diagnostic imaging/secondary
MH  - Carcinoma, Hepatocellular/*diagnostic imaging/secondary
MH  - Female
MH  - Fluorodeoxyglucose F18
MH  - Humans
MH  - Liver Neoplasms/*pathology
MH  - Male
MH  - Middle Aged
MH  - Positron-Emission Tomography/*methods
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Radiography
MH  - Radiopharmaceuticals
MH  - Survival Rate
EDAT- 2010/11/11 06:00
MHDA- 2011/03/18 06:00
CRDT- 2010/11/11 06:00
PHST- 2010/11/11 06:00 [entrez]
PHST- 2010/11/11 06:00 [pubmed]
PHST- 2011/03/18 06:00 [medline]
AID - radiol.10100672 [pii]
AID - 10.1148/radiol.10100672 [doi]
PST - ppublish
SO  - Radiology. 2011 Feb;258(2):515-23. doi: 10.1148/radiol.10100672. Epub 2010 Nov 9.


PMID- 21062796
OWN - NLM
STAT- MEDLINE
DCOM- 20110419
LR  - 20211020
IS  - 1523-5866 (Electronic)
IS  - 1522-8517 (Linking)
VI  - 13
IP  - 1
DP  - 2011 Jan
TI  - Therapeutic efficacy and safety of TRAIL-producing human adipose tissue-derived
      mesenchymal stem cells against experimental brainstem glioma.
PG  - 61-9
LID - 10.1093/neuonc/noq147 [doi]
AB  - Mesenchymal stem cells (MSCs) have an extensive migratory capacity for gliomas,
      which is comparable to that of neural stem cells. Among the various types of
      MSCs, human adipose tissue-derived MSCs (hAT-MSC) emerge as one of the most
      attractive vehicles for gene therapy because of their high throughput, lack of
      ethical concerns, and availability and ease of isolation. We evaluated the
      therapeutic potential and safety of genetically engineered hAT-MSCs encoding the 
      tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) against brainstem
      gliomas. Human AT-MSCs were isolated from human fat tissue, characterized, and
      transfected with TRAIL using nucleofector. The therapeutic potential of
      TRAIL-producing hAT-MSCs (hAT-MSC.TRAIL) was confirmed using in vitro and in vivo
      studies. The final fate of injected hAT-MSCs was traced in long-survival animals.
      The characterization of hAT-MSCs revealed the expression of MSC-specific
      cell-type markers and their differentiation potential into mesenchymal lineage.
      Short-term outcomes included a 56.3% reduction of tumor volume (P < .001) with
      increased apoptosis (3.03-fold, P < .05) in animals treated with hAT-MSC.TRAIL
      compared with the control groups. Long-term outcomes included a significant
      survival benefit in the hAT-MSC.TRAIL-treated group (26 days of median survival
      in the control group vs 84 days in the hAT-MSC.TRAIL-treated group, P < .0001),
      without any evidence of mesenchymal differentiation in vivo. Our study
      demonstrated the therapeutic efficacy and safety of nonvirally engineered
      hAT-MSCs against brainstem gliomas and showed the possibility of stem-cell-based 
      targeted gene therapy for clinical application.
FAU - Choi, Seung Ah
AU  - Choi SA
AD  - Division of Pediatric Neurosurgery, Seoul National University Children's
      Hospital, 101 Daehagno, Jongno-gu, Seoul 110-744, South Korea.
FAU - Hwang, Sung-Kyun
AU  - Hwang SK
FAU - Wang, Kyu-Chang
AU  - Wang KC
FAU - Cho, Byung-Kyu
AU  - Cho BK
FAU - Phi, Ji Hoon
AU  - Phi JH
FAU - Lee, Ji Yeoun
AU  - Lee JY
FAU - Jung, Hee Won
AU  - Jung HW
FAU - Lee, Do-Hun
AU  - Lee DH
FAU - Kim, Seung-Ki
AU  - Kim SK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101109
PL  - England
TA  - Neuro Oncol
JT  - Neuro-oncology
JID - 100887420
RN  - 0 (RNA, Messenger)
RN  - 0 (TNF-Related Apoptosis-Inducing Ligand)
SB  - IM
MH  - Adipose Tissue/*cytology/metabolism
MH  - Animals
MH  - Blotting, Western
MH  - Brain Stem Neoplasms/genetics/pathology/*therapy
MH  - Cell Differentiation
MH  - Cells, Cultured
MH  - Fluorescent Antibody Technique
MH  - *Genetic Therapy
MH  - Glioma/genetics/pathology/*therapy
MH  - Humans
MH  - Mesenchymal Stem Cells/*physiology
MH  - RNA, Messenger/genetics
MH  - Rats
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - TNF-Related Apoptosis-Inducing Ligand/*genetics/metabolism
MH  - Xenograft Model Antitumor Assays
PMC - PMC3018907
EDAT- 2010/11/11 06:00
MHDA- 2011/04/20 06:00
CRDT- 2010/11/11 06:00
PHST- 2010/11/11 06:00 [entrez]
PHST- 2010/11/11 06:00 [pubmed]
PHST- 2011/04/20 06:00 [medline]
AID - noq147 [pii]
AID - 10.1093/neuonc/noq147 [doi]
PST - ppublish
SO  - Neuro Oncol. 2011 Jan;13(1):61-9. doi: 10.1093/neuonc/noq147. Epub 2010 Nov 9.


PMID- 21062565
OWN - NLM
STAT- MEDLINE
DCOM- 20110223
LR  - 20211020
IS  - 1478-5242 (Electronic)
IS  - 0960-1643 (Linking)
VI  - 60
IP  - 580
DP  - 2010 Nov
TI  - Last but not least: the ethics of the ordinary.
PG  - 863-4
LID - 10.3399/bjgp10X539425 [doi]
FAU - Papanikitas, Andrew
AU  - Papanikitas A
FAU - Toon, Peter
AU  - Toon P
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Gen Pract
JT  - The British journal of general practice : the journal of the Royal College of
      General Practitioners
JID - 9005323
SB  - IM
CIN - Br J Gen Pract. 2012 Feb;62(595):e143-6. PMID: 22520792
MH  - General Practice/*ethics
MH  - Humans
MH  - Physician-Patient Relations/*ethics
PMC - PMC2965985
EDAT- 2010/11/11 06:00
MHDA- 2011/02/24 06:00
CRDT- 2010/11/11 06:00
PHST- 2010/11/11 06:00 [entrez]
PHST- 2010/11/11 06:00 [pubmed]
PHST- 2011/02/24 06:00 [medline]
AID - 10.3399/bjgp10X539425 [doi]
PST - ppublish
SO  - Br J Gen Pract. 2010 Nov;60(580):863-4. doi: 10.3399/bjgp10X539425.


PMID- 21062432
OWN - NLM
STAT- MEDLINE
DCOM- 20110623
LR  - 20211020
IS  - 1747-5341 (Electronic)
IS  - 1747-5341 (Linking)
VI  - 5
DP  - 2010 Nov 9
TI  - Respice...prospice: philosophy, ethics and medical care- past, present, and
      future.
PG  - 17
LID - 10.1186/1747-5341-5-17 [doi]
FAU - Giordano, James
AU  - Giordano J
LA  - eng
PT  - Editorial
DEP - 20101109
PL  - England
TA  - Philos Ethics Humanit Med
JT  - Philosophy, ethics, and humanities in medicine : PEHM
JID - 101258058
SB  - IM
MH  - *Ethics, Medical
MH  - *Ethics, Research
MH  - Health Policy
MH  - Humans
MH  - Patient Care/*ethics
MH  - *Philosophy, Medical
PMC - PMC2991273
EDAT- 2010/11/11 06:00
MHDA- 2011/06/24 06:00
CRDT- 2010/11/11 06:00
PHST- 2010/10/05 00:00 [received]
PHST- 2010/11/09 00:00 [accepted]
PHST- 2010/11/11 06:00 [entrez]
PHST- 2010/11/11 06:00 [pubmed]
PHST- 2011/06/24 06:00 [medline]
AID - 1747-5341-5-17 [pii]
AID - 10.1186/1747-5341-5-17 [doi]
PST - epublish
SO  - Philos Ethics Humanit Med. 2010 Nov 9;5:17. doi: 10.1186/1747-5341-5-17.


PMID- 21061872
OWN - NLM
STAT- MEDLINE
DCOM- 20101214
LR  - 20191111
IS  - 0886-6708 (Print)
IS  - 0886-6708 (Linking)
VI  - 25
IP  - 5
DP  - 2010
TI  - Does asking adolescents about suicidal ideation induce negative mood state?
PG  - 677-88
AB  - Two studies examined the potential for negative mood induction through
      participating in suicidal ideation questionnaire research. Items immediately
      preceding mood state measures were hypothesized to influence mood state in a
      negative or positive direction, depending on their emotional content. Study 1
      involved 129 adolescents. Mood state decreased nonsignificantly following items
      on suicidal-type ideation and significantly improved following a series of
      positive affect items. Study 2 followed up 71 of the original participants 3
      years later using a briefer version of the original questionnaire. Here no
      significant differences in mood state were found at any measurement point. In
      both studies, the salience of items preceding the mood measure explained a
      significant proportion of variance in mood state. We concluded that negative mood
      induction effects were minimal. Ethical implications are discussed.
FAU - Deeley, Stephanie T
AU  - Deeley ST
AD  - La Trobe University, Bundoora, Australia. s.t.deeley@univex.com
FAU - Love, Anthony W
AU  - Love AW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Violence Vict
JT  - Violence and victims
JID - 8916436
SB  - IM
MH  - Adolescent
MH  - Adolescent Behavior/*psychology
MH  - *Affect
MH  - Depression/psychology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Interpersonal Relations
MH  - Male
MH  - Mental Health
MH  - Motivation
MH  - *Negativism
MH  - Risk Factors
MH  - *Self Efficacy
MH  - *Suicidal Ideation
MH  - Young Adult
EDAT- 2010/11/11 06:00
MHDA- 2010/12/16 06:00
CRDT- 2010/11/11 06:00
PHST- 2010/11/11 06:00 [entrez]
PHST- 2010/11/11 06:00 [pubmed]
PHST- 2010/12/16 06:00 [medline]
AID - 10.1891/0886-6708.25.5.677 [doi]
PST - ppublish
SO  - Violence Vict. 2010;25(5):677-88. doi: 10.1891/0886-6708.25.5.677.


PMID- 21061716
OWN - NLM
STAT- MEDLINE
DCOM- 20110103
LR  - 20101109
IS  - 1592-7830 (Print)
IS  - 1592-7830 (Linking)
VI  - 32
IP  - 3
DP  - 2010 Jul-Sep
TI  - [Biological risk in health. Risk to third parties: medical-legal focus.
      Responsible behavior of the competent physician].
PG  - 318-22
AB  - The responsibility of the occupational physician (OP) is discussed within the
      particular topic of biological risk generated by health care workers (HCW) versus
      third parties in health care settings. The present contribution offers keys of
      interpretation regarding current Italian legislation and passed sentences, taking
      into account principles of occupational medicine, the ICOH code of ethics for
      occupational health professionals, as well as duties and tasks of OP, employers
      and employees. Most of the responsibilities stand on employers, but OP has a
      primary duty of information and to judge fitness for work. It is underlined the
      difficult interpretation of the current legislation and indications. Behaviour of
      the OP could be censored in case of particular fitness for work or in case of
      inadequate information, as well as if the comprehension of information is not
      verified or when indication to minimize the risk are not controlled.
FAU - Rodriguez, Daniele
AU  - Rodriguez D
AD  - Medicina Legale, Universita degli Studi di Padova, Italy.
LA  - ita
PT  - English Abstract
PT  - Journal Article
TT  - Rischio biologico in sanita. Il rischio verse terzi: focus medico-legale. La
      condotta responsabile del Medico Competente.
PL  - Italy
TA  - G Ital Med Lav Ergon
JT  - Giornale italiano di medicina del lavoro ed ergonomia
JID - 9712708
SB  - IM
MH  - *Health Personnel
MH  - Humans
MH  - *Infectious Disease Transmission, Professional-to-Patient/prevention & control
MH  - Italy
MH  - Occupational Medicine/*legislation & jurisprudence
MH  - Risk Factors
EDAT- 2010/11/11 06:00
MHDA- 2011/01/05 06:00
CRDT- 2010/11/11 06:00
PHST- 2010/11/11 06:00 [entrez]
PHST- 2010/11/11 06:00 [pubmed]
PHST- 2011/01/05 06:00 [medline]
PST - ppublish
SO  - G Ital Med Lav Ergon. 2010 Jul-Sep;32(3):318-22.


PMID- 21061700
OWN - NLM
STAT- MEDLINE
DCOM- 20110103
LR  - 20131121
IS  - 1592-7830 (Print)
IS  - 1592-7830 (Linking)
VI  - 32
IP  - 3
DP  - 2010 Jul-Sep
TI  - [Biological risk for health care workers: updates and good medical practices from
      a multicentre study: foreword].
PG  - 232-4
AB  - The topic of health and safety of health care workers exposed to biological
      agents appears as a relevant issue for the occupational physician, within a
      multidisciplinary context, while taking into account technical and scientific
      evolution, ethics, and principles of Occupational Health, current legislation.
      Through description of methods and results of a large multicentre study, good
      medical practices are proposed within the various areas of competence in
      occupational health, in particular for a few priority topics, such as blood borne
      or airborne diseases, fitness for work and danger to third parties,
      epidemiologic, clinical and medico-legal aspects.
FAU - Porru, Stefano
AU  - Porru S
AD  - Coordinatore del gruppo di lavoro sul rischio biologico - Sezione Tematica di
      Medicina Preventiva dei Lavoratori della Sanita, SIMLII, Universita di Brescia,
      Brescia, Italy. porru@med.unibs.it
LA  - ita
PT  - English Abstract
PT  - Journal Article
TT  - II rischio biologico per i lavoratori della sanita: aggiornamenti e buone prassi 
      alla luce di uno studio multicentrico: introduzione.
PL  - Italy
TA  - G Ital Med Lav Ergon
JT  - Giornale italiano di medicina del lavoro ed ergonomia
JID - 9712708
RN  - 0 (Biological Products)
SB  - IM
MH  - Biological Products/*adverse effects
MH  - Blood-Borne Pathogens
MH  - *Health Personnel
MH  - Humans
MH  - Multicenter Studies as Topic
MH  - Occupational Diseases/*epidemiology/*etiology
MH  - Risk Factors
EDAT- 2010/11/11 06:00
MHDA- 2011/01/05 06:00
CRDT- 2010/11/11 06:00
PHST- 2010/11/11 06:00 [entrez]
PHST- 2010/11/11 06:00 [pubmed]
PHST- 2011/01/05 06:00 [medline]
PST - ppublish
SO  - G Ital Med Lav Ergon. 2010 Jul-Sep;32(3):232-4.


PMID- 21049167
OWN - NLM
STAT- MEDLINE
DCOM- 20110323
LR  - 20190907
IS  - 1678-4561 (Electronic)
IS  - 1413-8123 (Linking)
VI  - 15 Suppl 2
DP  - 2010 Oct
TI  - [Perceptions of students, professors and users regarding the ethical dimension at
      odontology education].
PG  - 3255-64
LID - S1413-81232010000800031 [pii]
AB  - The present work analyzes the perception that students, professors and users of
      the ambulatory have concerning the professional education in its ethical
      dimension, in two odontology course, a public and a private one from Bahia. It
      also aims to compare these perceptions with the observed ambulatory practice.
      With these purposes the following research instruments had been applied:
      questionnaires for 283 students, not-directive interviews with 32 professors and 
      36 users, and participatory observation in ambulatory practice in the two
      courses. The results show that (1) students and professors perceive the high
      stimulation of the ethic dimension, (2) students learn the basic concepts of
      bioethics theoretical knowledge, and (3) the majority of the users feel respected
      considering these principles. However, the observation of the ambulatory practice
      does not confirm all that perception results.
FAU - Matos, Mariangela Silva de
AU  - Matos MS
AD  - Faculdade de Odontologia, Universidade Federal da Bahia, Salvador, Ba.
      marismatos@yahoo.com.br
FAU - Tenorio, Robson
AU  - Tenorio R
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Percepcao de alunos, professores e usuarios acerca da dimensao etica na formacao 
      de graduandos de odontologia.
PL  - Brazil
TA  - Cien Saude Colet
JT  - Ciencia & saude coletiva
JID - 9713483
SB  - IM
MH  - *Attitude
MH  - Education, Dental/*ethics
MH  - *Faculty
MH  - Humans
MH  - *Patients
MH  - *Students, Dental
EDAT- 2010/11/11 06:00
MHDA- 2011/03/24 06:00
CRDT- 2010/11/05 06:00
PHST- 2007/07/20 00:00 [received]
PHST- 2008/01/07 00:00 [accepted]
PHST- 2010/11/05 06:00 [entrez]
PHST- 2010/11/11 06:00 [pubmed]
PHST- 2011/03/24 06:00 [medline]
AID - S1413-81232010000800031 [pii]
AID - 10.1590/s1413-81232010000800031 [doi]
PST - ppublish
SO  - Cien Saude Colet. 2010 Oct;15 Suppl 2:3255-64. doi:
      10.1590/s1413-81232010000800031.


PMID- 21049153
OWN - NLM
STAT- MEDLINE
DCOM- 20110323
LR  - 20190907
IS  - 1678-4561 (Electronic)
IS  - 1413-8123 (Linking)
VI  - 15 Suppl 2
DP  - 2010 Oct
TI  - [Right of access to the assisted human reproduction: bioethics discussions].
PG  - 3129-38
LID - S1413-81232010000800017 [pii]
AB  - The objective of this study is to evaluate how is configured the right of access 
      to the assisted human reproduction service (AHRS). It was developed through
      documentary research in official sources of the Brazilian Federal Government.
      From the criteria of the analysis of content were analyzed: 1 government
      directive and 6 projects of law, divided in 3 thematic areas (access to what?;
      access to whom?; and conditions and criteria of access), revealing nucleus of
      meaning that had been explored in this research. This revealed that the right of 
      access in official documents is exclusive, and morally induced by a professional 
      category and its arbitrariness. The joint of these nucleus of meaning with the
      everyday bioethics was of extreme relevance to deal with the different kinds of
      family that are being legitimated through these proposals of regulation, as well 
      as the ethical questions intrinsic to the formulation of these texts, which remit
      us to the idea of traditional family, model not hegemonic anymore in our society,
      and social and legally surpassed by new familiar conceptions that also demand
      visibility and legitimacy from the State. The study intends to be one more
      possibility of reflection about the questions that involve the right of access to
      the AHRS from the everyday bioethics issues.
FAU - Medeiros, Luciana Soares de
AU  - Medeiros LS
AD  - Programa de Pos-Graduacao em Saude Publica, Centro de Ciencias da Saude,
      Universidade Federal de Santa Catarina, Campus Universitario Trindade,
      Florianopolis, SC. lsmedeiros@gmail.com
FAU - Verdi, Marta Inez Machado
AU  - Verdi MI
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Direito de acesso ao servico de reproducao humana assistida: discussoes
      bioeticas.
PL  - Brazil
TA  - Cien Saude Colet
JT  - Ciencia & saude coletiva
JID - 9713483
SB  - IM
MH  - *Bioethical Issues
MH  - Brazil
MH  - Health Services Accessibility/*ethics
MH  - *Human Rights
MH  - Humans
MH  - Reproductive Techniques, Assisted/*ethics
EDAT- 2010/11/11 06:00
MHDA- 2011/03/24 06:00
CRDT- 2010/11/05 06:00
PHST- 2007/09/27 00:00 [received]
PHST- 2008/06/27 00:00 [accepted]
PHST- 2010/11/05 06:00 [entrez]
PHST- 2010/11/11 06:00 [pubmed]
PHST- 2011/03/24 06:00 [medline]
AID - S1413-81232010000800017 [pii]
AID - 10.1590/s1413-81232010000800017 [doi]
PST - ppublish
SO  - Cien Saude Colet. 2010 Oct;15 Suppl 2:3129-38. doi:
      10.1590/s1413-81232010000800017.


PMID- 21060101
OWN - NLM
STAT- MEDLINE
DCOM- 20101206
LR  - 20101109
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Linking)
VI  - 75
IP  - 19
DP  - 2010 Nov 9
TI  - Sedation for the imminently dying: survey results from the AAN Ethics Section.
PG  - 1753; author reply 1753-4
LID - 10.1212/WNL.0b013e3181fac691 [doi]
FAU - Rady, Mohamed Y
AU  - Rady MY
FAU - Verheijde, Joseph L
AU  - Verheijde JL
LA  - eng
PT  - Comment
PT  - Letter
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
SB  - IM
CON - Neurology. 2010 Apr 20;74(16):1303-9. PMID: 20237307
MH  - *Attitude to Death
MH  - *Data Collection
MH  - Deep Sedation/*ethics
MH  - Humans
MH  - Palliative Care/*ethics
EDAT- 2010/11/10 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/11/10 06:00
PHST- 2010/11/10 06:00 [entrez]
PHST- 2010/11/10 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 75/19/1753 [pii]
AID - 10.1212/WNL.0b013e3181fac691 [doi]
PST - ppublish
SO  - Neurology. 2010 Nov 9;75(19):1753; author reply 1753-4. doi:
      10.1212/WNL.0b013e3181fac691.


PMID- 21059727
OWN - NLM
STAT- MEDLINE
DCOM- 20101122
LR  - 20220310
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 341
DP  - 2010 Nov 8
TI  - Ethics of mitochondrial gene replacement: from bench to bedside.
PG  - c6021
LID - 10.1136/bmj.c6021 [doi]
LID - bmj.c6021 [pii]
FAU - Bredenoord, Annelien L
AU  - Bredenoord AL
AD  - University Medical Center Utrecht, Julius Center for Health Sciences and Primary 
      Care Stratenum, 6.131, PO Box 85500, 3508 GA Utrecht, Netherlands.
      A.L.Bredenoord@umcutrecht.nl
FAU - Braude, Peter
AU  - Braude P
LA  - eng
GR  - 086034/WT_/Wellcome Trust/United Kingdom
GR  - G0701172/MRC_/Medical Research Council/United Kingdom
GR  - G0801061/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
DEP - 20101108
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
RN  - 0 (DNA, Mitochondrial)
SB  - IM
MH  - DNA, Mitochondrial/*genetics
MH  - Diffusion of Innovation
MH  - *Ethics, Research
MH  - Gene Transfer Techniques/*ethics
MH  - *Genes, Mitochondrial
MH  - Genetic Therapy/*ethics/methods
MH  - Genome, Mitochondrial
MH  - Humans
MH  - Informed Consent
MH  - Mitochondrial Diseases/genetics/*prevention & control
MH  - Risk Assessment
EDAT- 2010/11/10 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/11/10 06:00
PHST- 2010/11/10 06:00 [entrez]
PHST- 2010/11/10 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1136/bmj.c6021 [doi]
PST - epublish
SO  - BMJ. 2010 Nov 8;341:c6021. doi: 10.1136/bmj.c6021.


PMID- 21059701
OWN - NLM
STAT- MEDLINE
DCOM- 20110118
LR  - 20220331
IS  - 1471-6771 (Electronic)
IS  - 0007-0912 (Linking)
VI  - 106
IP  - 1
DP  - 2011 Jan
TI  - Ultrasound reduces the minimum effective local anaesthetic volume compared with
      peripheral nerve stimulation for interscalene block.
PG  - 124-30
LID - 10.1093/bja/aeq306 [doi]
AB  - BACKGROUND: Previous studies have demonstrated that lower local anaesthetic (LA) 
      volumes can be used for ultrasound (US)-guided interscalene brachial plexus block
      (ISB). However, no study has examined whether US can reduce the volume required
      when compared with nerve stimulation (NS) for ISB. Our aim was to do this by
      comparing the minimum effective analgesic volumes (MEAVs). METHODS: After ethics 
      approval and informed consent, patients undergoing shoulder surgery were
      recruited to this randomized, double-blind, up-down sequential allocation study. 
      The volume used for both US and NS was dependent upon the success or failure of
      the previous block. Success was defined as a verbal rating score of 0/10, 30 min 
      after surgery. Ten needle passes were allowed before defaulting to the opposite
      group. Patients received general anaesthesia. Pain scores and analgesic
      consumption were assessed by a blinded observer. Statistical comparisons of
      continuous variables were performed using Student's t-test and Mann-Whitney
      U-test as appropriate. Categorical variables were analysed using chi(2) test.
      MEAV values were estimated using log-transformed up-down independent pairs
      analysis and probit regression. Significance was assumed at P<0.05 (two-sided).
      RESULTS: The MEAV required to provide effective analgesia was significantly
      (P=0.034) reduced to 0.9 ml [95% confidence interval (CI) 0.3-2.8] in the US
      group from 5.4 ml (95% CI 3.4-8.6) in the NS group. Fewer needle passes were
      needed to identify the brachial plexus with US (1 vs 3; P<0.0001) and patients
      had less pain at 30 min after surgery (P=0.03). CONCLUSIONS: US reduces the
      number of attempts, LA volume, and postoperative pain when compared with NS for
      ISB.
FAU - McNaught, A
AU  - McNaught A
AD  - Department of Anaesthesia, Sunnybrook Health Sciences Centre, University of
      Toronto, Toronto, ON, Canada.
FAU - Shastri, U
AU  - Shastri U
FAU - Carmichael, N
AU  - Carmichael N
FAU - Awad, I T
AU  - Awad IT
FAU - Columb, M
AU  - Columb M
FAU - Cheung, J
AU  - Cheung J
FAU - Holtby, R M
AU  - Holtby RM
FAU - McCartney, C J L
AU  - McCartney CJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20101108
PL  - England
TA  - Br J Anaesth
JT  - British journal of anaesthesia
JID - 0372541
RN  - 0 (Anesthetics, Local)
RN  - UF599785JZ (Fentanyl)
SB  - IM
CIN - Br J Anaesth. 2011 Apr;106(4):600; author reply 601-2. PMID: 21421606
CIN - Br J Anaesth. 2011 Apr;106(4):600-1; author reply 601-2. PMID: 21421607
CIN - Br J Anaesth. 2011 Jul;107(1):103; author reply 103-4. PMID: 21685116
MH  - Adult
MH  - Aged
MH  - Anesthetics, Local/*administration & dosage
MH  - Arthroscopy
MH  - Brachial Plexus/anatomy & histology/diagnostic imaging/physiology
MH  - Double-Blind Method
MH  - Drug Administration Schedule
MH  - Electric Stimulation/methods
MH  - Female
MH  - Fentanyl/administration & dosage
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Block/*methods
MH  - Pain Measurement/methods
MH  - Shoulder Joint/surgery
MH  - Ultrasonography, Interventional/methods
EDAT- 2010/11/10 06:00
MHDA- 2011/01/19 06:00
CRDT- 2010/11/10 06:00
PHST- 2010/11/10 06:00 [entrez]
PHST- 2010/11/10 06:00 [pubmed]
PHST- 2011/01/19 06:00 [medline]
AID - S0007-0912(17)33372-X [pii]
AID - 10.1093/bja/aeq306 [doi]
PST - ppublish
SO  - Br J Anaesth. 2011 Jan;106(1):124-30. doi: 10.1093/bja/aeq306. Epub 2010 Nov 8.


PMID- 21059686
OWN - NLM
STAT- MEDLINE
DCOM- 20120322
LR  - 20211020
IS  - 1741-3850 (Electronic)
IS  - 1741-3842 (Linking)
VI  - 33
IP  - 3
DP  - 2011 Sep
TI  - Achieving public health legal preparedness: how dissonant views on public health 
      law threaten emergency preparedness and response.
PG  - 361-8
LID - 10.1093/pubmed/fdq092 [doi]
AB  - BACKGROUND: Effective management of modern public health emergencies requires the
      coordinated efforts of multiple agencies representing various disciplines.
      Organizational culture differences between public health (PH) and emergency
      management (EM) entities may hinder inter-agency collaboration. We examine how PH
      and EM differ in their approach to PH law and how such differences affect their
      collaboration towards PH preparedness. METHODS: We conducted 144 semi-structured 
      interviews with local and state PH and EM officials between April 2008 and
      November 2009. Thematic qualitative analysis in ATLAS.ti was used to extract
      characteristics of each agency's approach to PH legal preparedness. RESULTS: Two 
      conflicting approaches to the law emerge. The PH approach is characterized by
      perceived uncertainty regarding legal authority over preparedness planning tasks;
      expectation for guidance on interpretation of existing laws; and concern about
      individual and organizational liability. The EM approach reveals perception of
      broad legal authority; flexible interpretation of existing laws; and ethical
      concerns over infringement of individual freedoms and privacy. CONCLUSIONS:
      Distinct interpretations of preparedness law impede effective collaboration for
      PH preparedness. Clarification of legal authority mandates, designation within
      laws of scope of preparedness activities and guidance on interpretation of
      current federal and state laws are needed.
FAU - Botoseneanu, Anda
AU  - Botoseneanu A
AD  - Department of Health Management and Policy, University of Michigan School of
      Public Health, Ann Arbor, MI 48109-2029, USA. andabm@umich.edu
FAU - Wu, Helen
AU  - Wu H
FAU - Wasserman, Jeffrey
AU  - Wasserman J
FAU - Jacobson, Peter D
AU  - Jacobson PD
LA  - eng
GR  - T32-AG027708/AG/NIA NIH HHS/United States
GR  - TP000102/TP/OPHPR CDC HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20101108
PL  - England
TA  - J Public Health (Oxf)
JT  - Journal of public health (Oxford, England)
JID - 101188638
SB  - IM
MH  - Civil Defense/*legislation & jurisprudence/organization & administration
MH  - Cooperative Behavior
MH  - Disaster Planning/legislation & jurisprudence
MH  - Emergency Responders/*legislation & jurisprudence
MH  - Health Planning Guidelines
MH  - Humans
MH  - *Interinstitutional Relations
MH  - Public Health/*legislation & jurisprudence
MH  - State Government
MH  - United States
PMC - PMC3159509
EDAT- 2010/11/10 06:00
MHDA- 2012/03/23 06:00
CRDT- 2010/11/10 06:00
PHST- 2010/11/10 06:00 [entrez]
PHST- 2010/11/10 06:00 [pubmed]
PHST- 2012/03/23 06:00 [medline]
AID - fdq092 [pii]
AID - 10.1093/pubmed/fdq092 [doi]
PST - ppublish
SO  - J Public Health (Oxf). 2011 Sep;33(3):361-8. doi: 10.1093/pubmed/fdq092. Epub
      2010 Nov 8.


PMID- 21059635
OWN - NLM
STAT- MEDLINE
DCOM- 20110315
LR  - 20101129
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 12
DP  - 2010 Dec
TI  - Biobanks for non-clinical purposes and the new law on forensic biobanks: does the
      Italian context protect the rights of minors?
PG  - 775-8
LID - 10.1136/jme.2010.037606 [doi]
AB  - Biobanks are an important resource for medical research. Genetic research on
      biological material from minors can yield valuable information that can improve
      our understanding of genetic-environmental interactions and the genesis and
      development of early onset genetic disorders. The major ethical concerns relating
      to biobanks concern consent, privacy, confidentiality, commercialisation, and the
      right to know or not to know. However, research on paediatric data raises
      specific governance and ethical questions with regard to consent and privacy. We 
      have considered the Italian normative context focusing on what is mentioned in
      each document on the ethical and legal requirements that guarantee the rights of 
      minors. We found out that there is no systematic reflection on the ethical and
      policy issues arising from the participation of minors in biobank research.
      Moreover, we have focused on the same aspects for the new Italian Law on the
      National Forensic Biobank.
FAU - Tozzo, Pamela
AU  - Tozzo P
AD  - Department of Environmental Medicine and Public Health, Legal Medicine Unit,
      University of Padua, Via Falloppio 50, 35121, Padua, Italy. pamela.tozzo@unipd.it
FAU - Pegoraro, Renzo
AU  - Pegoraro R
FAU - Caenazzo, Luciana
AU  - Caenazzo L
LA  - eng
PT  - Journal Article
DEP - 20101108
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Biological Specimen Banks/ethics/*legislation & jurisprudence
MH  - Confidentiality/ethics/legislation & jurisprudence
MH  - Forensic Genetics/*ethics/*legislation & jurisprudence
MH  - Humans
MH  - Informed Consent/ethics/legislation & jurisprudence
MH  - Italy
MH  - Minors/*legislation & jurisprudence
MH  - Patient Rights/*ethics/*legislation & jurisprudence
EDAT- 2010/11/10 06:00
MHDA- 2011/03/16 06:00
CRDT- 2010/11/10 06:00
PHST- 2010/11/10 06:00 [entrez]
PHST- 2010/11/10 06:00 [pubmed]
PHST- 2011/03/16 06:00 [medline]
AID - jme.2010.037606 [pii]
AID - 10.1136/jme.2010.037606 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Dec;36(12):775-8. doi: 10.1136/jme.2010.037606. Epub 2010 Nov 
      8.


PMID- 21059631
OWN - NLM
STAT- MEDLINE
DCOM- 20110519
LR  - 20110217
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 3
DP  - 2011 Mar
TI  - The return of individual research findings in paediatric genetic research.
PG  - 179-83
LID - 10.1136/jme.2010.037473 [doi]
AB  - The combination of the issue of return of individual genetic results/incidental
      findings and paediatric biobanks is not much discussed in ethical literature. The
      traditional arguments pro and con return of such findings focus on principles
      such as respect for persons, autonomy and solidarity. Two dimensions have been
      distilled from the discussion on return of individual results in a genetic
      research context: the respect for a participant's autonomy and the duty of the
      researcher. Concepts such as autonomy and solidarity do not fit easily in the
      discussion when paediatric biobanks are concerned. Although parents may be
      allowed to enrol children in minimal risk genetic research on stored tissue
      samples, they should not be given the option to opt out of receiving important
      health information. Also, children have a right to an open future: parents do not
      have the right to access any genetic data that a biobank holds on their children.
      In this respect, the guidelines on genetic testing of minors are applicable. With
      regard to the duty of the researcher the question of whether researchers have a
      more stringent duty to return important health information when their research
      subjects are children is more difficult to answer. A researcher's primary duty is
      to perform useful research, a policy to return individual results must not hamper
      this task. The fact that vulnerable children are concerned, is an additional
      factor that should be considered when a policy of returning results is laid down 
      for a specific collection or research project.
FAU - Hens, Kristien
AU  - Hens K
AD  - Katholieke Universiteit Leuven, Centre for Biomedical Ethics and Law,
      Kapucijnenvoer 35/3 Box 7001, 3000 Leuven, Belgium. kristien.hens@med.kuleuven.be
FAU - Nys, Herman
AU  - Nys H
FAU - Cassiman, Jean-Jacques
AU  - Cassiman JJ
FAU - Dierickx, Kris
AU  - Dierickx K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101108
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Child
MH  - Child, Preschool
MH  - Databases, Genetic/ethics
MH  - Duty to Recontact/ethics/legislation & jurisprudence
MH  - Female
MH  - Genetic Research/*ethics/legislation & jurisprudence
MH  - Genetic Testing
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Infant
MH  - Informed Consent/*ethics/legislation & jurisprudence
MH  - Male
MH  - Parents/psychology
MH  - Patient Rights/*ethics
MH  - Research Subjects
MH  - Truth Disclosure/*ethics
EDAT- 2010/11/10 06:00
MHDA- 2011/05/20 06:00
CRDT- 2010/11/10 06:00
PHST- 2010/11/10 06:00 [entrez]
PHST- 2010/11/10 06:00 [pubmed]
PHST- 2011/05/20 06:00 [medline]
AID - jme.2010.037473 [pii]
AID - 10.1136/jme.2010.037473 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Mar;37(3):179-83. doi: 10.1136/jme.2010.037473. Epub 2010 Nov 
      8.


PMID- 21059536
OWN - NLM
STAT- MEDLINE
DCOM- 20110113
LR  - 20190902
IS  - 0317-1671 (Print)
IS  - 0317-1671 (Linking)
VI  - 37
IP  - 6
DP  - 2010 Nov
TI  - Observations on the ethical and social aspects of disorders of consciousness.
PG  - 758-68
AB  - The care of chronically unconscious patients raises vexing medical, ethical, and 
      social questions concerning diagnosis, prognosis, communication with family
      members, and decision making, including the withdrawal of life support. We
      provide updates on major controversies surrounding disorders of consciousness.
      Issues such as withdrawal of artificial nutrition and hydration - which had been 
      considered "settled" by many in the medical, legal and ethical communities - have
      resurfaced under the pressure of social groups and religious authorities. Some
      assumptions about the level of awareness and the prognosis of vegetative state
      and minimal conscious patients are questioned by advances in clinical care
      because of insights produced by neuroscience research techniques, particularly
      functional neuroimaging. Both the clinical and neuroscience dimensions of
      disorders of consciousness raise complex issues such as resource allocation and
      high levels of diagnostic inaccuracies (at least, for the vegetative state). We
      conclude by highlighting areas needing further research and collaboration.
FAU - Racine, Eric
AU  - Racine E
AD  - Neuroethics Research Unit, Department of Medicine and Department of Social and
      Preventive Medicine, Universite de Montreal, Canada.
FAU - Rodrigue, Catherine
AU  - Rodrigue C
FAU - Bernat, James L
AU  - Bernat JL
FAU - Riopelle, Richard
AU  - Riopelle R
FAU - Shemie, Sam D
AU  - Shemie SD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Can J Neurol Sci
JT  - The Canadian journal of neurological sciences. Le journal canadien des sciences
      neurologiques
JID - 0415227
SB  - IM
CIN - Can J Neurol Sci. 2010 Nov;37(6):713. PMID: 21059527
MH  - Consciousness Disorders/classification/*therapy
MH  - *Ethics, Medical
MH  - Humans
MH  - Life Support Care/*ethics
MH  - Persistent Vegetative State/physiopathology
MH  - *Sociology
EDAT- 2010/11/10 06:00
MHDA- 2011/01/14 06:00
CRDT- 2010/11/10 06:00
PHST- 2010/11/10 06:00 [entrez]
PHST- 2010/11/10 06:00 [pubmed]
PHST- 2011/01/14 06:00 [medline]
AID - 687U30547U2Q61Q6 [pii]
AID - 10.1017/s0317167100051416 [doi]
PST - ppublish
SO  - Can J Neurol Sci. 2010 Nov;37(6):758-68. doi: 10.1017/s0317167100051416.


PMID- 21059151
OWN - NLM
STAT- MEDLINE
DCOM- 20110307
LR  - 20191210
IS  - 1440-1800 (Electronic)
IS  - 1320-7881 (Linking)
VI  - 17
IP  - 4
DP  - 2010 Dec
TI  - 'Now we call it research': participatory health research involving marginalized
      women who use drugs.
PG  - 336-45
LID - 10.1111/j.1440-1800.2010.00507.x [doi]
AB  - In this paper, we discuss and analyse the strategies employed and challenges
      encountered when conducting a recent feminist participatory action research study
      with highly marginalized women who were illicit drug users in an inner city area 
      of Vancouver, Canada. Through an analysis of the political economy of
      participatory praxis within current neoliberal contexts, we focus on three main
      areas: (i) reconceptualizing the pragmatics of participation; (ii) the
      microeconomic implications of participatory research, including ethical issues in
      payment for research participation; and (iii) the value and limits of using
      research as a tool for activism and empowerment. We conclude with a brief
      discussion of what we see to be some of the most salient social justice
      implications arising from feminist and participatory approaches to health
      research within neoliberal political spaces.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Salmon, Amy
AU  - Salmon A
AD  - Women's Health Research Institute and University of British Columbia, School of
      Population and Public Health, Vancouver, British Columbia, Canada.
      asalmon@cw.bc.ca
FAU - Browne, Annette J
AU  - Browne AJ
FAU - Pederson, Ann
AU  - Pederson A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Australia
TA  - Nurs Inq
JT  - Nursing inquiry
JID - 9505881
RN  - 0 (Illicit Drugs)
MH  - Canada/epidemiology
MH  - Consumer Advocacy
MH  - Cooperative Behavior
MH  - Female
MH  - *Feminism
MH  - Health Services Research/*methods
MH  - Humans
MH  - *Illicit Drugs
MH  - Power, Psychological
MH  - *Prejudice
MH  - Substance-Related Disorders/epidemiology/*psychology
MH  - *Women's Health
EDAT- 2010/11/10 06:00
MHDA- 2011/03/08 06:00
CRDT- 2010/11/10 06:00
PHST- 2010/11/10 06:00 [entrez]
PHST- 2010/11/10 06:00 [pubmed]
PHST- 2011/03/08 06:00 [medline]
AID - 10.1111/j.1440-1800.2010.00507.x [doi]
PST - ppublish
SO  - Nurs Inq. 2010 Dec;17(4):336-45. doi: 10.1111/j.1440-1800.2010.00507.x.


PMID- 21058886
OWN - NLM
STAT- MEDLINE
DCOM- 20110421
LR  - 20101109
IS  - 1557-7708 (Electronic)
IS  - 1075-5535 (Linking)
VI  - 16
IP  - 11
DP  - 2010 Nov
TI  - A qualitative study on urut Melayu: the traditional Malay massage.
PG  - 1201-5
LID - 10.1089/acm.2009.0592 [doi]
AB  - OBJECTIVE: We conducted this study to gain an insight into the experiences and
      views of practitioners of urut Melayu, the traditional Malay massage, which will 
      be used in developing a preliminary framework of the urut Melayu process. DESIGN:
      We adopted a qualitative study design. We carried out a total of five focus group
      discussions (FGDs) comprising 6-10 urut Melayu practitioners each. LOCATION: We
      carried out three FGDs at the Traditional and Complementary Medicine Division,
      Ministry of Health and two FGDs at a district Health Clinic. SUBJECTS: All
      participants of the FGDs were urut Melayu practitioners registered with the
      Ministry of Health. Three (3) FGDs comprised all females while two comprised all 
      males. A total of 12 males and 24 females participated in the study. RESULTS: We 
      identified six themes from the study, namely, indications for urut Melayu, the
      urut Melayu technique, other treatments in conjunction with urut Melayu, outcome 
      of urut Melayu, ethics of urut Melayu, and practitioners' source of skills and
      knowledge. CONCLUSIONS: Urut Melayu is a unique form of massage carried out for
      various purposes. Although it is common belief that there are vast differences in
      the way it is performed from one practitioner to another, this study revealed
      that similarities do exist and there is potential to develop a standard framework
      for urut Melayu for regulation and training purposes.
FAU - Anuar, Haniza Mohd
AU  - Anuar HM
AD  - Institute for Health Systems Research, Jalan Rumah Sakit Bangsar, Kuala Lumpur,
      Malaysia. haniza.ma@ihsr.gov.my
FAU - Fadzil, Fariza
AU  - Fadzil F
FAU - Sallehuddin, Shaheeda Mohd
AU  - Sallehuddin SM
FAU - Ahmad, Norlaili
AU  - Ahmad N
FAU - Abd Ghani, Norsuria
AU  - Abd Ghani N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Altern Complement Med
JT  - Journal of alternative and complementary medicine (New York, N.Y.)
JID - 9508124
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Focus Groups
MH  - Health Personnel/education
MH  - Humans
MH  - Malaysia
MH  - Male
MH  - Massage/*methods
MH  - *Medicine, Traditional
MH  - Middle Aged
MH  - Qualitative Research
EDAT- 2010/11/10 06:00
MHDA- 2011/04/22 06:00
CRDT- 2010/11/10 06:00
PHST- 2010/11/10 06:00 [entrez]
PHST- 2010/11/10 06:00 [pubmed]
PHST- 2011/04/22 06:00 [medline]
AID - 10.1089/acm.2009.0592 [doi]
PST - ppublish
SO  - J Altern Complement Med. 2010 Nov;16(11):1201-5. doi: 10.1089/acm.2009.0592.


PMID- 21058824
OWN - NLM
STAT- MEDLINE
DCOM- 20110210
LR  - 20190211
IS  - 1099-9809 (Print)
IS  - 1077-341X (Linking)
VI  - 16
IP  - 4
DP  - 2010 Oct
TI  - Qualitative research in multicultural psychology: philosophical underpinnings,
      popular approaches, and ethical considerations.
PG  - 581-589
LID - 10.1037/a0012051 [doi]
AB  - This article reviews the current and emerging status of qualitative research in
      psychology. The particular value of diverse philosophical paradigms and varied
      inquiry approaches to the advancement of psychology generally, and multicultural 
      psychology specifically, is emphasized. Three specific qualitative inquiry
      approaches anchored in diverse philosophical research paradigms are highlighted: 
      consensual qualitative research, grounded theory, and participatory action
      research. The article concludes by highlighting important ethical considerations 
      in multicultural qualitative research.
CI  - PsycINFO Database Record (c) 2010 APA, all rights reserved.
FAU - Ponterotto, Joseph G
AU  - Ponterotto JG
AD  - Division of Psychological & Educational Services.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Cultur Divers Ethnic Minor Psychol
JT  - Cultural diversity & ethnic minority psychology
JID - 100956435
SB  - IM
MH  - Cultural Diversity
MH  - *Ethics, Research
MH  - Humans
MH  - *Philosophy
MH  - Philosophy, Nursing
MH  - Psychology/*methods
MH  - *Qualitative Research
MH  - *Research Design
EDAT- 2010/11/10 06:00
MHDA- 2011/02/11 06:00
CRDT- 2010/11/10 06:00
PHST- 2010/11/10 06:00 [entrez]
PHST- 2010/11/10 06:00 [pubmed]
PHST- 2011/02/11 06:00 [medline]
AID - 2010-22619-018 [pii]
AID - 10.1037/a0012051 [doi]
PST - ppublish
SO  - Cultur Divers Ethnic Minor Psychol. 2010 Oct;16(4):581-589. doi:
      10.1037/a0012051.


PMID- 21045596
OWN - NLM
STAT- MEDLINE
DCOM- 20101122
LR  - 20211020
IS  - 1944-7884 (Electronic)
IS  - 1525-4135 (Linking)
VI  - 55 Suppl 1
DP  - 2010 Dec
TI  - Implementation science for the prevention and treatment of HIV/AIDS.
PG  - S27-31
LID - 10.1097/QAI.0b013e3181f9c1da [doi]
AB  - Implementation science is the scientific study of methods to promote the
      integration of research findings and evidence-based interventions into health
      care policy and practice and hence to improve the quality and effectiveness of
      health services and care. Implementation science is distinguished from monitoring
      and evaluation by its emphasis on the use of the scientific method. The origins
      of implementation science include operations research, industrial engineering,
      and management science. Today, implementation science encompasses a broader range
      of methods and skills including decision science and operations research, health 
      systems research, health outcomes research, health and behavioral economics,
      epidemiology, statistics, organization and management science, finance, policy
      analysis, anthropology, sociology, and ethics. Examples of implementation science
      research are presented for HIV prevention (prevention of mother-to-child
      transmission of HIV, male circumcision) and HIV and drug use (syringe
      distribution, treating drug users with antiretroviral therapy and opioid
      substitution therapy). For implementation science to become an established field 
      in HIV/AIDS research, there needs to be better coordination between funders of
      research and funders of program delivery and greater consensus on scientific
      research approaches and standards of evidence.
FAU - Schackman, Bruce R
AU  - Schackman BR
AD  - Department of Public Health, Weill Cornell Medical College, New York, NY 10065,
      USA. brs2006@med.cornell.edu
LA  - eng
GR  - R01 DA027379/DA/NIDA NIH HHS/United States
GR  - R01 DA027379-01/DA/NIDA NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - J Acquir Immune Defic Syndr
JT  - Journal of acquired immune deficiency syndromes (1999)
JID - 100892005
SB  - IM
MH  - Biomedical Research
MH  - Female
MH  - HIV Infections/*prevention & control
MH  - Humans
MH  - Male
PMC - PMC3058234
MID - NIHMS244243
EDAT- 2010/11/10 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/11/04 06:00
PHST- 2010/11/04 06:00 [entrez]
PHST- 2010/11/10 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1097/QAI.0b013e3181f9c1da [doi]
AID - 00126334-201012011-00006 [pii]
PST - ppublish
SO  - J Acquir Immune Defic Syndr. 2010 Dec;55 Suppl 1:S27-31. doi:
      10.1097/QAI.0b013e3181f9c1da.


PMID- 21058109
OWN - NLM
STAT- MEDLINE
DCOM- 20110225
LR  - 20171116
IS  - 1520-5711 (Electronic)
IS  - 1054-3406 (Linking)
VI  - 20
IP  - 6
DP  - 2010 Nov
TI  - Review of draft FDA adaptive design guidance.
PG  - 1132-42
LID - 10.1080/10543406.2010.514455 [doi]
AB  - Recent draft Food and Drug Administration (FDA) guidelines on adaptive clinical
      trial design and conduct provide a useful background for both academic and
      industry clinical research leaders. The guidelines help to define the scope of
      the term "adaptive design" and clarify how adaptive designs can be a critical
      component of a development program. Adaptive designs are appealing because they
      hold the promise of conducting trials that can answer the scientific questions of
      interest with savings of time and resources while exposing fewer subjects to
      potentially risky therapies. Adaptive designs have been successfully used in
      clinical trials in all phases of development for many years, enabled by a variety
      of increasingly flexible and powerful statistical tools. Recent developments that
      enable adaptations based on emerging treatment differences have demonstrated
      potential to streamline the research enterprise, but issues remain in their
      implementation. Proper implementation of adaptive designs requires an adequate
      understanding of the inherent trade-offs that accompany their use. In exchange
      for potential efficiencies in resource utilization, adaptive trials suffer from
      limitations in scientific conclusions, complications and inefficiencies in the
      statistical analysis, and logistical difficulties relative to fixed sample or
      fixed duration trials. While scarce resources and ethical imperatives motivate
      serious consideration of adaptive designs, researchers should be fully aware of
      the advantages and disadvantages of adaptive designs and adopt them cautiously.
FAU - Cook, Thomas
AU  - Cook T
AD  - Department of Biostatistics and Medical Informatics, University of
      Wisconsin-Madison, Madison, Wisconsin, USA. cook@biostat.wisc.edu
FAU - DeMets, David L
AU  - DeMets DL
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Biopharm Stat
JT  - Journal of biopharmaceutical statistics
JID - 9200436
SB  - IM
MH  - Bias
MH  - Clinical Trials as Topic/*methods/statistics & numerical data
MH  - Data Interpretation, Statistical
MH  - Drug Approval/*methods
MH  - Guidelines as Topic
MH  - Humans
MH  - Models, Statistical
MH  - Reproducibility of Results
MH  - *Research Design
MH  - Treatment Outcome
MH  - United States
EDAT- 2010/11/09 06:00
MHDA- 2011/02/26 06:00
CRDT- 2010/11/09 06:00
PHST- 2010/11/09 06:00 [entrez]
PHST- 2010/11/09 06:00 [pubmed]
PHST- 2011/02/26 06:00 [medline]
AID - 929078470 [pii]
AID - 10.1080/10543406.2010.514455 [doi]
PST - ppublish
SO  - J Biopharm Stat. 2010 Nov;20(6):1132-42. doi: 10.1080/10543406.2010.514455.


PMID- 21058058
OWN - NLM
STAT- MEDLINE
DCOM- 20110304
LR  - 20181201
IS  - 1466-1799 (Electronic)
IS  - 0007-1668 (Linking)
VI  - 51
IP  - 5
DP  - 2010 Oct
TI  - The broiler breeder paradox: ethical, genetic and physiological perspectives, and
      suggestions for solutions.
PG  - 569-79
LID - 10.1080/00071668.2010.519121 [doi]
AB  - 1. Due to intensive selection, broiler chickens became the most efficient
      meat-producing animals because of their fast growth, supported by a virtually
      unlimited voluntary feed intake. These characteristics cause many problems in the
      management of broiler breeder hens because of the negative correlation between
      muscle growth and reproduction effectiveness. 2. This problem, namely the fast
      muscle growth versus reproduction health paradox, induces a second paradox,
      acceptable reproduction and health versus hunger stress and impaired welfare,
      because broiler breeder hens require dedicated programmes of feed restriction (1)
      to maximise egg and chick production and (2) to avoid metabolic disorders and
      mortality in broiler breeders. 3. Given that poultry selection is a global
      large-scale business and chickens are a prolific species, improvement in profit
      can only be obtained by selecting on feed conversion and/or for higher breast
      meat percentage, which will intensify the broiler-breeder paradox. 4. New feeding
      strategies are being studied, but it is questionable if the paradox can be solved
      by management tools alone. Because breeding and selection are long-term
      processes, involving animals, farmers, consumers, industry, environment etc., a
      more sustainable breeding goal needs to be determined by a multidisciplinary
      approach and an open debate between several actors in the discussion. 5. Using
      dwarf broiler breeder hens could be one alternative, because dwarf hens combine
      relatively good reproductive fitness with ad libitum feeding. Another possibility
      is to accept lower broiler productivity by assigning economic values to welfare
      and including integrity traits in an extended breeding goal.
FAU - Decuypere, E
AU  - Decuypere E
AD  - Department of Biosystems, Division Livestock-Nutrition-Quality, Katholieke
      Universiteit (KU) Leuven, Leuven, Belgium. Eddy.Decuypere@biw.kuleuven.be
FAU - Bruggeman, V
AU  - Bruggeman V
FAU - Everaert, N
AU  - Everaert N
FAU - Li, Yue
AU  - Li Y
FAU - Boonen, R
AU  - Boonen R
FAU - De Tavernier, J
AU  - De Tavernier J
FAU - Janssens, S
AU  - Janssens S
FAU - Buys, N
AU  - Buys N
LA  - eng
PT  - Lecture
PL  - England
TA  - Br Poult Sci
JT  - British poultry science
JID - 15740290R
SB  - IM
MH  - Animal Husbandry/ethics/*methods
MH  - Animal Welfare
MH  - Animals
MH  - Breeding/methods
MH  - Chickens/anatomy & histology/*genetics/physiology
MH  - Feeding Behavior
MH  - Female
MH  - Reproduction/genetics
EDAT- 2010/11/09 06:00
MHDA- 2011/03/05 06:00
CRDT- 2010/11/09 06:00
PHST- 2010/11/09 06:00 [entrez]
PHST- 2010/11/09 06:00 [pubmed]
PHST- 2011/03/05 06:00 [medline]
AID - 929152479 [pii]
AID - 10.1080/00071668.2010.519121 [doi]
PST - ppublish
SO  - Br Poult Sci. 2010 Oct;51(5):569-79. doi: 10.1080/00071668.2010.519121.


PMID- 21057850
OWN - NLM
STAT- MEDLINE
DCOM- 20110616
LR  - 20211020
IS  - 1438-7573 (Electronic)
IS  - 1438-7573 (Linking)
VI  - 12
IP  - 2
DP  - 2011 Apr
TI  - Auditory cortex electrical stimulation suppresses tinnitus in rats.
PG  - 185-201
LID - 10.1007/s10162-010-0246-z [doi]
AB  - Recent clinical studies have demonstrated that auditory cortex electrical
      stimulation (ACES) has yielded promising results in the suppression of patients' 
      tinnitus. However, the large variability in the efficacy of ACES-induced
      suppression across individuals has hindered its development into a reliable
      therapy. Due to ethical reasons, many issues cannot be comprehensively addressed 
      in patients. In order to search for effective stimulation targets and identify
      optimal stimulation strategies, we have developed the first rat model to test for
      the suppression of behavioral evidence of tone-induced tinnitus through ACES. Our
      behavioral results demonstrated that electrical stimulation of all channels
      (frequency bands) in the auditory cortex significantly suppressed behavioral
      evidence of tinnitus and enhanced hearing detection at the central level. Such
      suppression of tinnitus and enhancement of hearing detection were respectively
      demonstrated by a reversal of tone exposure compromised gap detection at 10-12,
      14-16, and 26-28 kHz and compromised prepulse inhibition at 10-12 and 26-28 kHz. 
      On the contrary, ACES did not induce behavioral changes in animals that did not
      manifest any behavioral evidence of tinnitus and compromised hearing detection
      following the same tone exposure. The results point out that tinnitus may be more
      related to compromised central auditory processing than hearing loss at the
      peripheral level. The ACES-induced suppression of behavioral evidence of tinnitus
      may involve restoration of abnormal central auditory processing.
FAU - Zhang, Jinsheng
AU  - Zhang J
AD  - Laboratory of Auditory Prostheses Research, Department of Otolaryngology-Head and
      Neck Surgery,Wayne State University School of Medicine, 4201 Saint Antoine,
      Detroit, MI 48201, USA. jinzhang@med.wayne.edu
FAU - Zhang, Yupeng
AU  - Zhang Y
FAU - Zhang, Xueguo
AU  - Zhang X
LA  - eng
GR  - R21 DC010059/DC/NIDCD NIH HHS/United States
GR  - R21 DC010059-01/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20101106
PL  - United States
TA  - J Assoc Res Otolaryngol
JT  - Journal of the Association for Research in Otolaryngology : JARO
JID - 100892857
SB  - IM
MH  - Animals
MH  - Auditory Cortex/*physiology
MH  - Behavior, Animal/physiology
MH  - *Electric Stimulation Therapy
MH  - Electrodes
MH  - Evoked Potentials, Auditory/physiology
MH  - Male
MH  - Models, Animal
MH  - Rats
MH  - Rats, Long-Evans
MH  - Tinnitus/*physiopathology/*therapy
MH  - Treatment Outcome
PMC - PMC3046330
EDAT- 2010/11/09 06:00
MHDA- 2011/06/17 06:00
CRDT- 2010/11/09 06:00
PHST- 2010/06/17 00:00 [received]
PHST- 2010/10/21 00:00 [accepted]
PHST- 2010/11/09 06:00 [entrez]
PHST- 2010/11/09 06:00 [pubmed]
PHST- 2011/06/17 06:00 [medline]
AID - 10.1007/s10162-010-0246-z [doi]
PST - ppublish
SO  - J Assoc Res Otolaryngol. 2011 Apr;12(2):185-201. doi: 10.1007/s10162-010-0246-z. 
      Epub 2010 Nov 6.


PMID- 21057603
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 1040-0419 (Print)
IS  - 1040-0419 (Linking)
VI  - 22
IP  - 1
DP  - 2010 Feb 1
TI  - Creativity and Ethics: The Relationship of Creative and Ethical Problem-Solving.
PG  - 74-89
AB  - Students of creativity have long been interested in the relationship between
      creativity and deviant behaviors such as criminality, mental disease, and
      unethical behavior. In the present study we wished to examine the relationship
      between creative thinking skills and ethical decision-making among scientists.
      Accordingly, 258 doctoral students in the health, biological, and social sciences
      were asked to complete a measure of creative processing skills (e.g., problem
      definition, conceptual combination, idea generation) and a measure of ethical
      decision-making examining four domains, data management, study conduct,
      professional practices, and business practices. It was found that ethical
      decision-making in all four of these areas was related to creative
      problem-solving processes with late cycle processes (e.g., idea generation and
      solution monitoring) proving particularly important. The implications of these
      findings for understanding the relationship between creative and deviant thought 
      are discussed.
FAU - Mumford, Michael D
AU  - Mumford MD
AD  - The University of Oklahoma.
FAU - Waples, Ethan P
AU  - Waples EP
FAU - Antes, Alison L
AU  - Antes AL
FAU - Brown, Ryan P
AU  - Brown RP
FAU - Connelly, Shane
AU  - Connelly S
FAU - Murphy, Stephen T
AU  - Murphy ST
FAU - Devenport, Lynn D
AU  - Devenport LD
LA  - eng
GR  - M01 RR014467/RR/NCRR NIH HHS/United States
GR  - R01 NS049535/NS/NINDS NIH HHS/United States
GR  - R01 NS049535-02/NS/NINDS NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Creat Res J
JT  - Creativity research journal
JID - 101279887
PMC - PMC2967769
MID - NIHMS179448
EDAT- 2010/11/09 06:00
MHDA- 2010/11/09 06:01
CRDT- 2010/11/09 06:00
PHST- 2010/11/09 06:00 [entrez]
PHST- 2010/11/09 06:00 [pubmed]
PHST- 2010/11/09 06:01 [medline]
AID - 10.1080/10400410903579619 [doi]
PST - ppublish
SO  - Creat Res J. 2010 Feb 1;22(1):74-89. doi: 10.1080/10400410903579619.


PMID- 21057269
OWN - NLM
STAT- MEDLINE
DCOM- 20110324
LR  - 20151119
IS  - 1529-7535 (Print)
IS  - 1529-7535 (Linking)
VI  - 11
IP  - 6
DP  - 2010 Nov
TI  - Use of extracorporeal technology during pandemics: ethical and staffing
      considerations.
PG  - 757-8
LID - 10.1097/PCC.0b013e3181e288a4 [doi]
FAU - Kissoon, Niranjan
AU  - Kissoon N
FAU - Bohn, Desmond
AU  - Bohn D
LA  - eng
PT  - Editorial
PL  - United States
TA  - Pediatr Crit Care Med
JT  - Pediatric critical care medicine : a journal of the Society of Critical Care
      Medicine and the World Federation of Pediatric Intensive and Critical Care
      Societies
JID - 100954653
SB  - IM
CIN - Pediatr Crit Care Med. 2010 Nov;11(6):714-7. PMID: 20453697
MH  - Adolescent
MH  - Cardiomyopathy, Dilated/*therapy/*virology
MH  - Child
MH  - Child, Preschool
MH  - Critical Care
MH  - *Disease Outbreaks
MH  - *Extracorporeal Membrane Oxygenation/ethics
MH  - High-Frequency Ventilation
MH  - Humans
MH  - Infant
MH  - Influenza A Virus, H1N1 Subtype/isolation & purification/pathogenicity
MH  - Influenza, Human/epidemiology/*therapy/*virology
MH  - Personnel Staffing and Scheduling
MH  - Respiratory Insufficiency/*therapy/*virology
EDAT- 2010/11/09 06:00
MHDA- 2011/03/25 06:00
CRDT- 2010/11/09 06:00
PHST- 2010/11/09 06:00 [entrez]
PHST- 2010/11/09 06:00 [pubmed]
PHST- 2011/03/25 06:00 [medline]
AID - 10.1097/PCC.0b013e3181e288a4 [doi]
AID - 00130478-201011000-00018 [pii]
PST - ppublish
SO  - Pediatr Crit Care Med. 2010 Nov;11(6):757-8. doi: 10.1097/PCC.0b013e3181e288a4.


PMID- 21057153
OWN - NLM
STAT- MEDLINE
DCOM- 20110929
LR  - 20161125
IS  - 2084-4336 (Electronic)
IS  - 1509-3492 (Linking)
VI  - 12
IP  - 5
DP  - 2010 Sep-Oct
TI  - Use of recombinant activated factor VII for reduction of perioperative blood loss
      during elective surgical correction of spine deformity in a Jehovah's Witness.
      Case report.
PG  - 448-58
AB  - Planned surgical procedures at patients who refuse allogenic blood transfusion
      because of religious convictions are important problem, not only medical but also
      ethical and juristical. At the study authors report the successful use of
      activated recombinant factor VII (rFVIIa) for the reduction of perioperative
      blood loss in four years old child - Jehovah's Witness, who had planned Torode
      kyphectomy. Applied perioperative management together with preparing to surgery
      with erythropoietin allowed for reduction of blood loss and avoiding of blood
      transfusion. Authors state, that appropriate perioperative proceeding makes a
      possibility of safe surgical procedures also at patients who refuse the
      transfusion.
FAU - Kacka, Katarzyna
AU  - Kacka K
AD  - Katedra i Klinika Ortopedii i Rehabilitacji w Zakopanem, Uniwersytet
      Jagiellonski, Collegium Medicum, Zakopane, Polska. katkacka@tlen.pl
FAU - Kacki, Wojciech
AU  - Kacki W
FAU - Merak, Joanna
AU  - Merak J
FAU - Bleka, Adam
AU  - Bleka A
LA  - eng
LA  - pol
PT  - Case Reports
PT  - Journal Article
PL  - Poland
TA  - Ortop Traumatol Rehabil
JT  - Ortopedia, traumatologia, rehabilitacja
JID - 101240146
RN  - 0 (Hematologic Agents)
RN  - 0 (Recombinant Proteins)
RN  - 11096-26-7 (Erythropoietin)
RN  - AC71R787OV (recombinant FVIIa)
RN  - EC 3.4.21.21 (Factor VIIa)
SB  - IM
MH  - Blood Loss, Surgical/*prevention & control
MH  - Child
MH  - Erythropoietin/*therapeutic use
MH  - Factor VIIa/*therapeutic use
MH  - Female
MH  - Hematologic Agents/*therapeutic use
MH  - Humans
MH  - Jehovah's Witnesses
MH  - Kyphosis/*surgery
MH  - Recombinant Proteins/therapeutic use
MH  - Spine/surgery
EDAT- 2010/11/09 06:00
MHDA- 2011/10/01 06:00
CRDT- 2010/11/09 06:00
PHST- 2010/11/09 06:00 [entrez]
PHST- 2010/11/09 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - 922681 [pii]
PST - ppublish
SO  - Ortop Traumatol Rehabil. 2010 Sep-Oct;12(5):448-58.


PMID- 21056361
OWN - NLM
STAT- MEDLINE
DCOM- 20110303
LR  - 20101108
IS  - 1166-7087 (Print)
IS  - 1166-7087 (Linking)
VI  - 20
IP  - 12
DP  - 2010 Nov
TI  - [Medicolegal aspects of chronic pelvic and perineal pain].
PG  - 886-91
LID - 10.1016/j.purol.2010.08.067 [doi]
AB  - OBJECTIVE: To review the medicolegal aspects of chronic pelvic and perineal pain.
      MATERIAL AND METHODS: The literature and the French Public Health Code were
      reviewed. The review of the literature was performed by searching the Medline
      database (National Library of Medicine). Search terms were either medical subject
      heading (MeSH) keywords (forensic medicine, legislation, pelvic pain,
      postoperative pain) or terms derived from the title or abstract. Search terms
      were used alone or in combinations by using the "AND" operator. The literature
      search was conducted from 1990 to the present time. RESULTS: Chronic pelvic and
      perineal pain raises a number of medicolegal issues: pain management is required 
      by law, chronic pelvic and perineal pain can be a complication of certain
      surgical procedures and may be the subject of patient complaints, certain medical
      or surgical treatments of chronic pelvic and perineal pain do not have a
      marketing authorisation or scientific validation with a high level of evidence,
      which can have medicolegal implications. The French law of 4 March 2002
      concerning patient rights and quality of the health care system defines a number 
      of legal obligations. All physicians must comply with good professional practices
      as defined by the code of medical ethics and scientific knowledge. All surgeons
      are required to provide the patient with honest, clear and appropriate
      information about the risks of a proposed operation, especially about the
      possible risk of pain. It is also advised to provide the patient with a written
      document. All physicians must subscribe a professional civil liability insurance 
      policy. Contraceptive vasectomy, that may be complicated by pain, is a particular
      case, subject to the French law of 4 July 2001, which requires the surgeon to
      provide the patient with written information and requires the patient to confirm 
      his request for vasectomy in writing after a 4-month period of reflection.
      CONCLUSION: The field of chronic pelvic and perineal pain comprises numerous and 
      major medicolegal implications, requiring compliance with good clinical practice 
      and legislation, especially the French law of 4 March 2002 concerning patient
      rights and quality of the health care system.
CI  - Copyright (c) 2010. Published by Elsevier Masson SAS.
FAU - Delavierre, D
AU  - Delavierre D
AD  - Service d'urologie-andrologie, CHR La Source, 14, avenue de l'Hopital, 45067
      Orleans cedex 2, France. delav.uro@orange.fr
FAU - Rigaud, J
AU  - Rigaud J
FAU - Sibert, L
AU  - Sibert L
FAU - Labat, J-J
AU  - Labat JJ
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Aspects medicolegaux des douleurs pelviperineales chroniques.
DEP - 20101014
PL  - France
TA  - Prog Urol
JT  - Progres en urologie : journal de l'Association francaise d'urologie et de la
      Societe francaise d'urologie
JID - 9307844
SB  - IM
MH  - Chronic Disease
MH  - France
MH  - Humans
MH  - *Liability, Legal
MH  - *Pelvic Pain/therapy
MH  - *Perineum
EDAT- 2010/11/09 06:00
MHDA- 2011/03/04 06:00
CRDT- 2010/11/09 06:00
PHST- 2010/08/06 00:00 [received]
PHST- 2010/08/16 00:00 [accepted]
PHST- 2010/11/09 06:00 [entrez]
PHST- 2010/11/09 06:00 [pubmed]
PHST- 2011/03/04 06:00 [medline]
AID - S1166-7087(10)00340-4 [pii]
AID - 10.1016/j.purol.2010.08.067 [doi]
PST - ppublish
SO  - Prog Urol. 2010 Nov;20(12):886-91. doi: 10.1016/j.purol.2010.08.067. Epub 2010
      Oct 14.


PMID- 21056150
OWN - NLM
STAT- MEDLINE
DCOM- 20110104
LR  - 20151119
IS  - 1879-1883 (Electronic)
IS  - 0002-9610 (Linking)
VI  - 200
IP  - 5
DP  - 2010 Nov
TI  - Educational intervention is effective in improving knowledge and confidence in
      surgical ethics-a prospective study.
PG  - 665-9
LID - 10.1016/j.amjsurg.2010.08.002 [doi]
AB  - BACKGROUND: Professionalism and ethics are Accreditation Council for Graduate
      Medical Education (ACGME) core competencies, but there is little evidence
      regarding the effectiveness of ethics education. METHODS: General surgery
      residents at the University of Pittsburgh completed questionnaires measuring
      attitudes and knowledge about surgical ethics before and after four 60-minute,
      faculty-facilitated seminars implementing the American College of Surgeons ethics
      curriculum. RESULTS: Most residents experienced ethical challenges at least once 
      every rotation: competition of interests (75%), professional obligations (75%),
      confidentiality (83%), truth telling (88%), surrogate decision making (91%), and 
      end-of-life issues (100%). The educational intervention increased both knowledge 
      about surgical ethics (P = .013) and confidence in dealing with competition of
      interests (P = .001), professional obligations (P = .011), truth telling (P =
      .013), confidentiality (P = .011), end-of-life issues (P = .007), and surrogate
      decision making (P = .052). Most residents recommended the American College of
      Surgeons text for future use (84%), considering ethics education a "standard"
      part of residency training (70%). CONCLUSIONS: Focused instruction using the
      American College of Surgeons ethics curriculum can effectively improve both
      knowledge and confidence about surgical ethics.
CI  - Published by Elsevier Inc.
FAU - Thirunavukarasu, Pragatheeshwar
AU  - Thirunavukarasu P
AD  - Department of Surgery, University of Pittsburgh, PA, USA.
FAU - Brewster, Luke P
AU  - Brewster LP
FAU - Pecora, Stephanie M
AU  - Pecora SM
FAU - Hall, Daniel E
AU  - Hall DE
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Surg
JT  - American journal of surgery
JID - 0370473
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Ethics, Medical/*education
MH  - General Surgery/*education
MH  - Humans
MH  - Internship and Residency/*ethics
MH  - Middle Aged
MH  - Pennsylvania
MH  - Professional Competence/*standards
MH  - Prospective Studies
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2010/11/09 06:00
MHDA- 2011/01/05 06:00
CRDT- 2010/11/09 06:00
PHST- 2010/05/10 00:00 [received]
PHST- 2010/08/06 00:00 [revised]
PHST- 2010/08/06 00:00 [accepted]
PHST- 2010/11/09 06:00 [entrez]
PHST- 2010/11/09 06:00 [pubmed]
PHST- 2011/01/05 06:00 [medline]
AID - S0002-9610(10)00467-8 [pii]
AID - 10.1016/j.amjsurg.2010.08.002 [doi]
PST - ppublish
SO  - Am J Surg. 2010 Nov;200(5):665-9. doi: 10.1016/j.amjsurg.2010.08.002.


PMID- 21055845
OWN - NLM
STAT- MEDLINE
DCOM- 20110406
LR  - 20101206
IS  - 0211-139X (Print)
IS  - 0211-139X (Linking)
VI  - 45
IP  - 6
DP  - 2010 Nov-Dec
TI  - [Resolving real dilemmas in the elderly. A comparative study in an Argentinian
      community].
PG  - 326-30
LID - 10.1016/j.regg.2010.06.001 [doi]
AB  - OBJECTIVES: To assess whether the differences in making decisions in real
      dilemmas between the institutionalised elderly and those living in the community 
      are dependent on the context and life history, as well as on its development and 
      subject matter. METHODS: Qualitative and cross-sectional study on resolving real 
      life dilemmas using interviews and story life. Two groups were assessed, each one
      with 40 elderly participants aged 65 and over, one group who lived in the
      community and attended a Retirement Centre, and the other group living in a Long 
      term Care Facility, in Rosario (Argentina). Answers to dilemmas in hypothetical
      and real contexts were assessed and were mainly about family, politics, welfare, 
      support, authority, personal coherence and life satisfaction topics. RESULTS:
      Most of those residing in the Long Term Care Facility reached a conventional
      stage of moral reasoning, and the main topics were family, support and
      socio-political issues. Those living in the community reached conventional and
      post-conventional stages and the main topics were authority, personal coherence, 
      and family, the latter with a negative trend. Social conditions and experience
      had a great influence on those living in the community and isolation in those
      living in Care Facilities. CONCLUSIONS: a) Moral reasoning depends on life
      contexts, b) it is not stereotyped, c) this knowledge must be incorporated into
      adult education programs in order to understand their developments from their own
      point of view and d) obtain a commitment from the rest of the society towards
      integration of the elderly, accepting their ethical postures even if these do not
      match current thinking.
CI  - Copyright (c) 2009 SEGG. Published by Elsevier Espana. All rights reserved.
FAU - Serrani Azcurra, Daniel Jorge Luis
AU  - Serrani Azcurra DJ
AD  - Facultad de Psicologia de la Universidad Nacional de Rosario, Rosario, Argentina.
      danielserrani@argentina.com
LA  - spa
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
TT  - Resolucion de dilemas reales en adultos mayores. Estudio comparativo en una
      comunidad argentina.
DEP - 20101104
PL  - Spain
TA  - Rev Esp Geriatr Gerontol
JT  - Revista espanola de geriatria y gerontologia
JID - 8009022
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Argentina
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - *Morals
EDAT- 2010/11/09 06:00
MHDA- 2011/04/07 06:00
CRDT- 2010/11/09 06:00
PHST- 2009/08/25 00:00 [received]
PHST- 2010/05/31 00:00 [revised]
PHST- 2010/06/05 00:00 [accepted]
PHST- 2010/11/09 06:00 [entrez]
PHST- 2010/11/09 06:00 [pubmed]
PHST- 2011/04/07 06:00 [medline]
AID - S0211-139X(10)00127-7 [pii]
AID - 10.1016/j.regg.2010.06.001 [doi]
PST - ppublish
SO  - Rev Esp Geriatr Gerontol. 2010 Nov-Dec;45(6):326-30. doi:
      10.1016/j.regg.2010.06.001. Epub 2010 Nov 4.


PMID- 21055610
OWN - NLM
STAT- MEDLINE
DCOM- 20101208
LR  - 20101108
IS  - 1097-6752 (Electronic)
IS  - 0889-5406 (Linking)
VI  - 138
IP  - 5
DP  - 2010 Nov
TI  - Litigation, legislation, and ethics. Who will speak for me?
PG  - 670-2
LID - 10.1016/j.ajodo.2010.07.015 [doi]
FAU - Jerrold, Laurance
AU  - Jerrold L
AD  - School of Orthodontics, Jacksonville University, Jacksonville, Fla., USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Orthod Dentofacial Orthop
JT  - American journal of orthodontics and dentofacial orthopedics : official
      publication of the American Association of Orthodontists, its constituent
      societies, and the American Board of Orthodontics
JID - 8610224
SB  - IM
MH  - Child
MH  - Child Abuse/ethics/*legislation & jurisprudence/prevention & control
MH  - Dentists/ethics/*legislation & jurisprudence
MH  - Humans
MH  - Malpractice/legislation & jurisprudence
MH  - *Mandatory Reporting/ethics
MH  - Standard of Care/ethics/legislation & jurisprudence
MH  - United States
EDAT- 2010/11/09 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/11/09 06:00
PHST- 2010/06/01 00:00 [received]
PHST- 2010/06/01 00:00 [revised]
PHST- 2010/07/01 00:00 [accepted]
PHST- 2010/11/09 06:00 [entrez]
PHST- 2010/11/09 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S0889-5406(10)00730-4 [pii]
AID - 10.1016/j.ajodo.2010.07.015 [doi]
PST - ppublish
SO  - Am J Orthod Dentofacial Orthop. 2010 Nov;138(5):670-2. doi:
      10.1016/j.ajodo.2010.07.015.


PMID- 21055506
OWN - NLM
STAT- MEDLINE
DCOM- 20101206
LR  - 20101108
IS  - 1097-6868 (Electronic)
IS  - 0002-9378 (Linking)
VI  - 203
IP  - 5
DP  - 2010 Nov
TI  - An ethically justified practical approach to offering, recommending, performing, 
      and referring for induced abortion and feticide.
PG  - e9; author reply e9
LID - 10.1016/j.ajog.2010.08.038 [doi]
LA  - eng
PT  - Comment
PT  - Letter
PL  - United States
TA  - Am J Obstet Gynecol
JT  - American journal of obstetrics and gynecology
JID - 0370476
SB  - IM
CON - Am J Obstet Gynecol. 2009 Dec;201(6):560.e1-6. PMID: 19762005
MH  - Abortion, Induced/*ethics
MH  - *Ethics, Medical
MH  - Female
MH  - Humans
MH  - Personal Autonomy
MH  - Pregnancy
EDAT- 2010/11/09 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/11/09 06:00
PHST- 2010/11/09 06:00 [entrez]
PHST- 2010/11/09 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S0002-9378(10)01041-0 [pii]
AID - 10.1016/j.ajog.2010.08.038 [doi]
PST - ppublish
SO  - Am J Obstet Gynecol. 2010 Nov;203(5):e9; author reply e9. doi:
      10.1016/j.ajog.2010.08.038.


PMID- 21054885
OWN - NLM
STAT- MEDLINE
DCOM- 20110322
LR  - 20220318
IS  - 1471-2458 (Electronic)
IS  - 1471-2458 (Linking)
VI  - 10
DP  - 2010 Nov 6
TI  - The modified NCEP ATP III criteria maybe better than the IDF criteria in
      diagnosing Metabolic Syndrome among Malays in Kuala Lumpur.
PG  - 678
LID - 10.1186/1471-2458-10-678 [doi]
AB  - BACKGROUND: Metabolic Syndrome is associated with increased risk for type 2
      diabetes and cardiovascular diseases. However, different diagnostic criteria have
      been recommended by different expert groups. In Malaysia, there is a lack of
      research comparing these different diagnostic criteria. Therefore, it is our aim 
      to study the concordance between the IDF and the modified NCEP ATP III
      definitions of Metabolic Syndrome among a Malay cohort in Kuala Lumpur; and to
      demonstrate if all participants have the same cardiometabolic risks. METHODS:
      This was an analytical cross sectional study. Ethics approval was obtained and
      informed consent was given by all participants. Anthropometric measurements,
      blood pressure, fasting blood glucose and lipid profile were taken following
      standard protocols. RESULTS: Metabolic Syndrome was diagnosed in 41.4% and 38.2% 
      participants using the modified NCEP and IDF criteria respectively. Among those
      diagnosed with Metabolic Syndrome by modified NCEP, 7.6% were missed by the IDF
      criteria. Participants diagnosed by the modified NCEP criteria had lower BMI and 
      waist circumference but had higher cardiometabolic risks than those diagnosed
      with both criteria. Their blood pressure, glucose, total cholesterol and
      triglyceride were more adverse than the IDF group. This demonstrated that central
      obesity may not be a prerequisite for the development of increased
      cardiometabolic risks within this Malay cohort. CONCLUSION: Metabolic syndrome is
      common in this Malay cohort regardless of the criterion used. The modified NCEP
      ATP III criteria may be more suitable in diagnosis of metabolic syndrome for this
      Malay cohort.
FAU - Moy, Foong Ming
AU  - Moy FM
AD  - Julius Centre University of Malaya, Department of Social & Preventive Medicine,
      Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
      moyfm@ummc.edu.my
FAU - Bulgiba, Awang
AU  - Bulgiba A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101106
PL  - England
TA  - BMC Public Health
JT  - BMC public health
JID - 100968562
SB  - IM
MH  - Adult
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/diagnosis
MH  - Diagnosis, Differential
MH  - Female
MH  - *Guidelines as Topic
MH  - Humans
MH  - Malaysia
MH  - Male
MH  - Metabolic Syndrome/*diagnosis/ethnology/etiology
MH  - Middle Aged
MH  - Risk Factors
PMC - PMC2989964
EDAT- 2010/11/09 06:00
MHDA- 2011/03/23 06:00
CRDT- 2010/11/09 06:00
PHST- 2010/08/22 00:00 [received]
PHST- 2010/11/06 00:00 [accepted]
PHST- 2010/11/09 06:00 [entrez]
PHST- 2010/11/09 06:00 [pubmed]
PHST- 2011/03/23 06:00 [medline]
AID - 1471-2458-10-678 [pii]
AID - 10.1186/1471-2458-10-678 [doi]
PST - epublish
SO  - BMC Public Health. 2010 Nov 6;10:678. doi: 10.1186/1471-2458-10-678.


PMID- 21054860
OWN - NLM
STAT- MEDLINE
DCOM- 20110118
LR  - 20220129
IS  - 1757-7241 (Electronic)
IS  - 1757-7241 (Linking)
VI  - 18
DP  - 2010 Nov 5
TI  - Prehospital randomised assessment of a mechanical compression device in cardiac
      arrest (PaRAMeDIC) trial protocol.
PG  - 58
LID - 10.1186/1757-7241-18-58 [doi]
AB  - BACKGROUND: Survival after out-of-hospital cardiac arrest is closely linked to
      the quality of CPR, but in real life, resuscitation during prehospital care and
      ambulance transport is often suboptimal. Mechanical chest compression devices
      deliver consistent chest compressions, are not prone to fatigue and could
      potentially overcome some of the limitations of manual chest compression.
      However, there is no high-quality evidence that they improve clinical outcomes,
      or that they are cost effective. The Prehospital Randomised Assessment of a
      Mechanical Compression Device In Cardiac Arrest (PARAMEDIC) trial is a pragmatic 
      cluster randomised study of the LUCAS-2 device in adult patients with
      non-traumatic out-of-hospital cardiac arrest. METHODS/DESIGN: The primary
      objective of this trial is to evaluate the effect of chest compression using
      LUCAS-2 on mortality at 30 days post out-of-hospital cardiac arrest, compared
      with manual chest compression. Secondary objectives of the study are to evaluate 
      the effects of LUCAS-2 on survival to 12 months, cognitive and quality of life
      outcomes and cost-effectiveness. METHODS: Ambulance service vehicles will be
      randomised to either manual compression (control) or LUCAS arms. Adult patients
      in out-of-hospital cardiac arrest, attended by a trial vehicle will be eligible
      for inclusion. Patients with traumatic cardiac arrest or who are pregnant will be
      excluded. The trial will recruit approximately 4000 patients from England, Wales 
      and Scotland. A waiver of initial consent has been approved by the Research
      Ethics Committees. Consent will be sought from survivors for participation in the
      follow-up phase. CONCLUSION: The trial will assess the clinical and cost
      effectiveness of the LUCAS-2 mechanical chest compression device. TRIAL
      REGISTRATION: The trial is registered on the International Standard Randomised
      Controlled Trial Number Registry (ISRCTN08233942).
FAU - Perkins, Gavin D
AU  - Perkins GD
AD  - Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick,
      Gibbet Hill Road, Coventry CV4 7AL, UK. g.d.perkins@warwick.ac.uk
FAU - Woollard, Malcolm
AU  - Woollard M
FAU - Cooke, Matthew W
AU  - Cooke MW
FAU - Deakin, Charles
AU  - Deakin C
FAU - Horton, Jessica
AU  - Horton J
FAU - Lall, Ranjit
AU  - Lall R
FAU - Lamb, Sarah E
AU  - Lamb SE
FAU - McCabe, Chris
AU  - McCabe C
FAU - Quinn, Tom
AU  - Quinn T
FAU - Slowther, Anne
AU  - Slowther A
FAU - Gates, Simon
AU  - Gates S
CN  - PARAMEDIC trial collaborators
LA  - eng
SI  - ISRCTN/ISRCTN08233942
GR  - 07/37/69/DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20101105
PL  - England
TA  - Scand J Trauma Resusc Emerg Med
JT  - Scandinavian journal of trauma, resuscitation and emergency medicine
JID - 101477511
SB  - IM
MH  - Adult
MH  - Ambulances
MH  - Cardiopulmonary Resuscitation/instrumentation/methods
MH  - Cluster Analysis
MH  - Cost-Benefit Analysis
MH  - *Emergency Medical Services
MH  - Heart Massage/*instrumentation
MH  - Humans
MH  - Myocardial Infarction/therapy
MH  - Out-of-Hospital Cardiac Arrest/*therapy
MH  - Survival Analysis
MH  - United Kingdom
PMC - PMC2993645
IR  - Hallam P
FIR - Hallam, Phil
IR  - Jenkins A
FIR - Jenkins, Andrew
IR  - Jones I
FIR - Jones, Ian
IR  - Lawrenson R
FIR - Lawrenson, Robin
IR  - Smyth M
FIR - Smyth, Mike
IR  - Whitfield R
FIR - Whitfield, Richard
IR  - Nicholl J
FIR - Nicholl, Jon
IR  - Snooks H
FIR - Snooks, Helen
IR  - Gray A
FIR - Gray, Alasdair
IR  - Moore F
FIR - Moore, Fionna
IR  - Long J
FIR - Long, John
IR  - Father Neil Baylis
FIR - Father Neil Baylis
IR  - Box M
FIR - Box, Martyn
IR  - Campbell M
FIR - Campbell, Marion
IR  - Rowan K
FIR - Rowan, Kathy
IR  - Nolan J
FIR - Nolan, Jerry
EDAT- 2010/11/09 06:00
MHDA- 2011/01/19 06:00
CRDT- 2010/11/09 06:00
PHST- 2010/09/17 00:00 [received]
PHST- 2010/11/05 00:00 [accepted]
PHST- 2010/11/09 06:00 [entrez]
PHST- 2010/11/09 06:00 [pubmed]
PHST- 2011/01/19 06:00 [medline]
AID - 1757-7241-18-58 [pii]
AID - 10.1186/1757-7241-18-58 [doi]
PST - epublish
SO  - Scand J Trauma Resusc Emerg Med. 2010 Nov 5;18:58. doi: 10.1186/1757-7241-18-58.


PMID- 21054365
OWN - NLM
STAT- MEDLINE
DCOM- 20101129
LR  - 20211020
IS  - 1475-6773 (Electronic)
IS  - 0017-9124 (Linking)
VI  - 45
IP  - 5 Pt 2
DP  - 2010 Oct
TI  - Data governance and stewardship: designing data stewardship entities and
      advancing data access.
PG  - 1442-55
LID - 10.1111/j.1475-6773.2010.01140.x [doi]
AB  - U.S. health policy is engaged in a struggle over access to health information, in
      particular, the conditions under which information should be accessible for
      research when appropriate privacy protections and security safeguards are in
      place. The expanded use of health information-an inevitable step in an
      information age-is widely considered be essential to health system reform. Models
      exist for the creation of data-sharing arrangements that promote proper use of
      information in a safe and secure environment and with attention to ethical
      standards. Data stewardship is a concept with deep roots in the science and
      practice of data collection, sharing, and analysis. Reflecting the values of fair
      information practice, data stewardship denotes an approach to the management of
      data, particularly data that can identify individuals. The concept of a data
      steward is intended to convey a fiduciary (or trust) level of responsibility
      toward the data. Data governance is the process by which responsibilities of
      stewardship are conceptualized and carried out. As the concept of health
      information data stewardship advances in a technology-enabled environment, the
      question is whether legal barriers to data access and use will begin to give way.
      One possible answer may lie in defining the public interest in certain data uses,
      tying provider participation in federal health programs to the release of
      all-payer data to recognized data stewardship entities for aggregation and
      management, and enabling such entities to foster and enable the creation of
      knowledge through research.
CI  - (c) Health Research and Educational Trust.
FAU - Rosenbaum, Sara
AU  - Rosenbaum S
AD  - Department of Health Policy, George Washington University, 2021 K Street NW,
      Suite 800, Washington, DC 20006, USA. sarar@gwu.edu
LA  - eng
PT  - Journal Article
DEP - 20100802
PL  - United States
TA  - Health Serv Res
JT  - Health services research
JID - 0053006
SB  - IM
MH  - *Access to Information/legislation & jurisprudence
MH  - Confidentiality/legislation & jurisprudence
MH  - Health Services/*statistics & numerical data
MH  - Health Services Research/*organization & administration
MH  - Humans
MH  - Information Dissemination/legislation & jurisprudence
MH  - Ownership/legislation & jurisprudence
MH  - United States
MH  - United States Agency for Healthcare Research and Quality
PMC - PMC2965885
EDAT- 2010/11/09 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/11/09 06:00
PHST- 2010/11/09 06:00 [entrez]
PHST- 2010/11/09 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1111/j.1475-6773.2010.01140.x [doi]
PST - ppublish
SO  - Health Serv Res. 2010 Oct;45(5 Pt 2):1442-55. doi:
      10.1111/j.1475-6773.2010.01140.x. Epub 2010 Aug 2.


PMID- 21054190
OWN - NLM
STAT- MEDLINE
DCOM- 20110425
LR  - 20161018
IS  - 1437-4331 (Electronic)
IS  - 1434-6621 (Linking)
VI  - 48 Suppl 1
DP  - 2010 Dec
TI  - Thrombophilia screening--at the right time, for the right patient, with a good
      reason.
PG  - S105-13
LID - 10.1515/CCLM.2010.367 [doi]
AB  - Thrombophilia can be identified in about half of all patients presenting with
      venous thromboembolism (VTE). Thrombophilia screening for various indications has
      increased tremendously, but whether the results of such tests help in the
      clinical management of patients is uncertain. Here, current recommendations for
      thrombophilia screening in selected groups of patients, and considerations
      whether other high-risk subjects should be tested are reviewed. The methods for
      determination of the most common thrombophilic defects (antithrombin, protein C, 
      protein S deficiencies, Factor V Leiden and prothrombin G20210A) associated with 
      strong to moderate risk of VTE are described, indicating the timing and location 
      of thrombophilia screening. Circumstances when a positive result of thrombophilia
      screening helps clinicians decide if adjustments of the anticoagulant regime are 
      needed are discussed. Finally, psychological, social and ethical dilemmas
      associated with thrombophilia screening are indicated.
FAU - Stegnar, Mojca
AU  - Stegnar M
AD  - Department of Vascular Diseases, University Medical Centre, Ljubljana, Slovenia. 
      mojca.stegnar@kclj.si
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20101105
PL  - Germany
TA  - Clin Chem Lab Med
JT  - Clinical chemistry and laboratory medicine
JID - 9806306
SB  - IM
MH  - Child
MH  - Female
MH  - Humans
MH  - Pregnancy
MH  - Pregnancy Complications, Hematologic/diagnosis
MH  - Risk Factors
MH  - Thrombophilia/complications/*diagnosis
EDAT- 2010/11/09 06:00
MHDA- 2011/04/26 06:00
CRDT- 2010/11/09 06:00
PHST- 2010/11/09 06:00 [entrez]
PHST- 2010/11/09 06:00 [pubmed]
PHST- 2011/04/26 06:00 [medline]
AID - 10.1515/CCLM.2010.367 [doi]
PST - ppublish
SO  - Clin Chem Lab Med. 2010 Dec;48 Suppl 1:S105-13. doi: 10.1515/CCLM.2010.367. Epub 
      2010 Nov 5.


PMID- 21053906
OWN - NLM
STAT- MEDLINE
DCOM- 20150112
LR  - 20191210
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 58
IP  - 23
DP  - 2010 Dec 8
TI  - Clostridium botulinum neurotoxin type B is heat-stable in milk and not
      inactivated by pasteurization.
PG  - 12557-61
LID - 10.1021/jf1028398 [doi]
AB  - Foodborne botulism is caused by the ingestion of foods containing botulinum
      neurotoxins (BoNTs). To study the heat stability of Clostridium botulinum
      neurotoxins, we needed to measure and compare the activity of botulinum
      neurotoxins, serotypes A and B, under various pasteurization conditions.
      Currently, the only accepted assay to detect active C. botulinum neurotoxin is an
      in vivo mouse bioassay, which raises ethical concerns with regard to the use of
      experimental animals. In this study, noninvasive methods were used to
      simultaneously detect and distinguish between active BoNT serotypes A and B in
      one reaction and sample. We developed an enzymatic activity assay employing
      internally quenched fluorogenic peptides corresponding to SNAP-25, for BoNT-A,
      and VAMP2, for BoNT-B, as an alternative method to the mouse bioassay. Because
      each peptide is labeled with different fluorophores, we were able to distinguish 
      between these two toxins. We used this method to analyze the heat stability of
      BoNT-A and BoNT-B. This study reports that conventional milk pasteurization (63
      degrees C, 30 min) inactivated BoNT serotype A; however, serotype B is
      heat-stable in milk and not inactivated by pasteurization. Using this activity
      assay, we also showed that the commonly used food processes such as acidity and
      pasteurization, which are known to inhibit C. botulinum growth and toxin
      production, are more effective in inactivating BoNT serotype A than serotype B
      when conventional pasteurization (63 degrees C, 30 min) is used.
FAU - Rasooly, Reuven
AU  - Rasooly R
AD  - Western Regional Research Center, Agricultural Research Service, U.S. Department 
      of Agriculture, Albany, California 94710, United States.
FAU - Do, Paula M
AU  - Do PM
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20101105
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0Y70779M1F (rimabotulinumtoxinB)
RN  - EC 3.4.24.69 (Botulinum Toxins)
RN  - EC 3.4.24.69 (Botulinum Toxins, Type A)
SB  - IM
MH  - Animals
MH  - Botulinum Toxins/*chemistry/metabolism
MH  - Botulinum Toxins, Type A/chemistry/metabolism
MH  - Cattle
MH  - Clostridium botulinum/growth & development/*metabolism
MH  - Food Contamination/analysis
MH  - Hot Temperature
MH  - Milk/*chemistry/microbiology
MH  - Pasteurization/*methods
EDAT- 2010/11/09 06:00
MHDA- 2015/01/13 06:00
CRDT- 2010/11/09 06:00
PHST- 2010/11/09 06:00 [entrez]
PHST- 2010/11/09 06:00 [pubmed]
PHST- 2015/01/13 06:00 [medline]
AID - 10.1021/jf1028398 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2010 Dec 8;58(23):12557-61. doi: 10.1021/jf1028398. Epub 2010 
      Nov 5.


PMID- 21053787
OWN - NLM
STAT- MEDLINE
DCOM- 20110201
LR  - 20101217
IS  - 0279-3695 (Print)
IS  - 0279-3695 (Linking)
VI  - 48
IP  - 12
DP  - 2010 Dec
TI  - Assessment for and response to adverse childhood experiences.
PG  - 51-61
LID - 10.3928/02793695-20100930-03 [doi]
AB  - Literature strongly suggests that early exposure to adverse childhood experiences
      (ACEs) disrupts crucial normal stages of childhood development and predisposes
      these individuals to subsequent psychiatric sequelae. Even with these data,
      little is found in nursing literature that discusses ACEs and their impact on
      adult mental health. Therefore, the purpose of this article is to address how
      nurses approach communication with clients about and assess for traumatic life
      experiences. In addition, screening measures for ACEs will be presented, along
      with discussion about ethical responsibilities of health professionals and
      researchers in asking about abuse.
CI  - Copyright 2010, SLACK Incorporated.
FAU - Waite, Roberta
AU  - Waite R
AD  - College of Nursing and Health Professions, Interdisciplinary Research Unit,
      Doctoral Nursing Department, Drexel University, Philadelphia, PA, USA.
      rlw26@drexel.edu
FAU - Gerrity, Patricia
AU  - Gerrity P
FAU - Arango, Roxana
AU  - Arango R
LA  - eng
PT  - Journal Article
DEP - 20101022
PL  - United States
TA  - J Psychosoc Nurs Ment Health Serv
JT  - Journal of psychosocial nursing and mental health services
JID - 8200911
SB  - IM
MH  - Adult Survivors of Child Abuse/*psychology
MH  - Advanced Practice Nursing
MH  - Child
MH  - Child Abuse/*rehabilitation
MH  - Disclosure
MH  - Humans
MH  - Middle Aged
MH  - Nurse's Role
MH  - Nurse-Patient Relations
MH  - *Nursing Assessment
MH  - Stress Disorders, Post-Traumatic/nursing/*prevention & control
EDAT- 2010/11/09 06:00
MHDA- 2011/02/02 06:00
CRDT- 2010/11/09 06:00
PHST- 2010/01/21 00:00 [received]
PHST- 2010/07/20 00:00 [accepted]
PHST- 2010/11/09 06:00 [entrez]
PHST- 2010/11/09 06:00 [pubmed]
PHST- 2011/02/02 06:00 [medline]
AID - 10.3928/02793695-20100930-03 [doi]
PST - ppublish
SO  - J Psychosoc Nurs Ment Health Serv. 2010 Dec;48(12):51-61. doi:
      10.3928/02793695-20100930-03. Epub 2010 Oct 22.


PMID- 21053650
OWN - NLM
STAT- MEDLINE
DCOM- 20110104
LR  - 20101108
IS  - 1029-0540 (Print)
IS  - 1029-0540 (Linking)
VI  - 46
IP  - 2
DP  - 2010
TI  - Globalization and the ethical implications for the Egyptian healthcare system.
PG  - 8-11
AB  - Globalization is creating an extraordinary transformation to the delivery,
      financing and access of healthcare throughout the world. Improving standards of
      treatment, based on higher international standards of care and the offering of
      far more affordable services, is positioning third-world countries as viable
      participants in a more global healthcare system. The Egyptian healthcare system
      is evolving to meet these higher expectations in an effort to attract wealthier
      international tourists. It is important to understand Egypt's evolving
      transformation into a medical service destination so policymakers may understand 
      the emerging ethical cocnerns this evolution may impose on this third-world and
      traditionally underserved population.
FAU - Haley, D Rob
AU  - Haley DR
AD  - Department of Public Health, University of North Florida, Jacksonville, USA.
FAU - Adel Khalifaa, Mohamed
AU  - Adel Khalifaa M
FAU - Beg, Sama A
AU  - Beg SA
FAU - Sobh, Nesma
AU  - Sobh N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - World Hosp Health Serv
JT  - World hospitals and health services : the official journal of the International
      Hospital Federation
JID - 9441450
MH  - Delivery of Health Care/economics/*ethics/organization & administration
MH  - Egypt
MH  - Health Services Accessibility/ethics
MH  - *Internationality
EDAT- 2010/11/09 06:00
MHDA- 2011/01/05 06:00
CRDT- 2010/11/09 06:00
PHST- 2010/11/09 06:00 [entrez]
PHST- 2010/11/09 06:00 [pubmed]
PHST- 2011/01/05 06:00 [medline]
PST - ppublish
SO  - World Hosp Health Serv. 2010;46(2):8-11.


PMID- 21053162
OWN - NLM
STAT- MEDLINE
DCOM- 20110623
LR  - 20110217
IS  - 1439-359X (Electronic)
IS  - 0939-7248 (Linking)
VI  - 21
IP  - 1
DP  - 2011 Jan
TI  - Loss of heterozygosity on chromosome 11p15.5 and relapse in hepatoblastomas.
PG  - 50-3
LID - 10.1055/s-0030-1267208 [doi]
AB  - BACKGROUND: IGF2 is a tumor suppressor gene at locus 11p15. Many hepatoblastomas 
      have loss of heterozygosity (LOH) at this locus. Earlier studies have not
      demonstrated any association between LOH and prognosis. Aim of the study was to
      evaluate the prognostic significance of LOH at 11p15.5 in hepatoblastomas.
      METHODS: DNA was isolated from normal liver and tumor tissue in 20 patients with 
      hepatoblastoma. PCR was performed and cases were classified as LOH present,
      absent or non-informative. Patients' follow-up data was analyzed using Fischer's 
      exact test and Kaplan-Meier survival analysis for relapse-free survival (RFS) in 
      relation to LOH. Ethical clearance was obtained from the institutional ethics
      board. RESULTS: All cases were informative for at least one microsatellite marker
      used. 4 of the 20 cases (20%) had LOH at 11p15.5. One patient died in the
      immediate postoperative period. 5 of 19 patients relapsed (26%). Of 4 patients
      who had LOH, 3 (75%) relapsed, the time to relapse being 7, 7 and 9 months,
      respectively. Of the 15 cases without LOH, 2 (13.3%) relapsed. 4 patients had
      mixed epithelial and mesenchymal histology; 3 of them had LOH. The 2 groups with 
      and without LOH were well matched. The RFS for patients with LOH (n=4) was 13%
      (mean survival time [MST]: 8.7 months; 95CI 6.7-10.7), while the RFS for cases
      without LOH (n=15) was 75% (MST: 100.7 months; 95CI 74.5-126.8). CONCLUSION:
      Mixed epithelial and mesenchymal histology is more frequently associated with LOH
      on chromosome 11p15.5 than pure epithelial histology. LOH on chromosome 11p15.5
      is associated with a significantly increased incidence of relapse and a
      significantly shorter relapse-free survival in patients with hepatoblastoma. The 
      risk of relapse is higher and the RFS lower both in standard-risk and high-risk
      patients with hepatoblastoma if they demonstrate the presence of LOH at 11p15.5.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Chitragar, S
AU  - Chitragar S
AD  - All India Institute of Medical Sciences, Pathology, New Delhi, India.
FAU - Iyer, V K
AU  - Iyer VK
FAU - Agarwala, S
AU  - Agarwala S
FAU - Gupta, S D
AU  - Gupta SD
FAU - Sharma, A
AU  - Sharma A
FAU - Wari, M N
AU  - Wari MN
LA  - eng
PT  - Journal Article
DEP - 20101104
PL  - United States
TA  - Eur J Pediatr Surg
JT  - European journal of pediatric surgery : official journal of Austrian Association 
      of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie
JID - 9105263
SB  - IM
MH  - Child, Preschool
MH  - Chromosomes, Human, Pair 11
MH  - Female
MH  - Hepatoblastoma/*genetics/pathology
MH  - Humans
MH  - Infant
MH  - Liver Neoplasms/*genetics/pathology
MH  - *Loss of Heterozygosity
MH  - Male
MH  - Neoplasm Recurrence, Local/*genetics
MH  - Risk Factors
EDAT- 2010/11/06 06:00
MHDA- 2011/06/24 06:00
CRDT- 2010/11/06 06:00
PHST- 2010/11/06 06:00 [entrez]
PHST- 2010/11/06 06:00 [pubmed]
PHST- 2011/06/24 06:00 [medline]
AID - 10.1055/s-0030-1267208 [doi]
PST - ppublish
SO  - Eur J Pediatr Surg. 2011 Jan;21(1):50-3. doi: 10.1055/s-0030-1267208. Epub 2010
      Nov 4.


PMID- 21051602
OWN - NLM
STAT- MEDLINE
DCOM- 20101206
LR  - 20101105
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Linking)
VI  - 330
IP  - 6005
DP  - 2010 Nov 5
TI  - Research ethics. Questions from China snag U.S. trial of nerve-rerouting
      procedure.
PG  - 741
LID - 10.1126/science.330.6005.741 [doi]
FAU - Xin, Hao
AU  - Xin H
LA  - eng
PT  - News
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
SB  - IM
MH  - Animals
MH  - Child
MH  - China
MH  - Clinical Trials as Topic
MH  - Ethics, Research
MH  - Humans
MH  - Nerve Transfer/*methods
MH  - Patient Selection
MH  - Selection Bias
MH  - Spinal Cord Injuries/complications/*surgery
MH  - Spinal Dysraphism/*surgery
MH  - Spinal Nerves/surgery
MH  - United States
MH  - Urinary Bladder, Neurogenic/etiology/*surgery
EDAT- 2010/11/06 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/11/06 06:00
PHST- 2010/11/06 06:00 [entrez]
PHST- 2010/11/06 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 330/6005/741 [pii]
AID - 10.1126/science.330.6005.741 [doi]
PST - ppublish
SO  - Science. 2010 Nov 5;330(6005):741. doi: 10.1126/science.330.6005.741.


PMID- 21051546
OWN - NLM
STAT- MEDLINE
DCOM- 20110524
LR  - 20101208
IS  - 1941-2452 (Electronic)
IS  - 0884-5336 (Linking)
VI  - 25
IP  - 6
DP  - 2010 Dec
TI  - A.S.P.E.N. ethics position paper.
PG  - 672-9
LID - 10.1177/0884533610385429 [doi]
CN  - A.S.P.E.N. Ethics Position Paper Task Force
FAU - Barrocas, Albert
AU  - Barrocas A
FAU - Geppert, Cynthia
AU  - Geppert C
FAU - Durfee, Sharon M
AU  - Durfee SM
FAU - Maillet, Julie O'Sullivan
AU  - Maillet JO
FAU - Monturo, Cheryl
AU  - Monturo C
FAU - Mueller, Charles
AU  - Mueller C
FAU - Stratton, Kathleen
AU  - Stratton K
FAU - Valentine, Christina
AU  - Valentine C
CN  - A.S.P.E.N. Board of Directors
CN  - American Society for Parenteral and Enteral Nutrition
LA  - eng
PT  - Journal Article
PT  - Practice Guideline
DEP - 20101104
PL  - United States
TA  - Nutr Clin Pract
JT  - Nutrition in clinical practice : official publication of the American Society for
      Parenteral and Enteral Nutrition
JID - 8606733
SB  - IM
MH  - Bioethical Issues
MH  - Dementia/therapy
MH  - Humans
MH  - Nutritional Support/*ethics
MH  - Persistent Vegetative State/therapy
MH  - Terminal Care/ethics
EDAT- 2010/11/06 06:00
MHDA- 2011/05/25 06:00
CRDT- 2010/11/06 06:00
PHST- 2010/11/06 06:00 [entrez]
PHST- 2010/11/06 06:00 [pubmed]
PHST- 2011/05/25 06:00 [medline]
AID - 0884533610385429 [pii]
AID - 10.1177/0884533610385429 [doi]
PST - ppublish
SO  - Nutr Clin Pract. 2010 Dec;25(6):672-9. doi: 10.1177/0884533610385429. Epub 2010
      Nov 4.


PMID- 21051301
OWN - NLM
STAT- MEDLINE
DCOM- 20110701
LR  - 20110228
IS  - 1878-0946 (Electronic)
IS  - 1744-165X (Linking)
VI  - 16
IP  - 2
DP  - 2011 Apr
TI  - Ethical issues in perinatal genetics.
PG  - 70-3
LID - 10.1016/j.siny.2010.10.004 [doi]
AB  - Ethics is an essential dimension of perinatal genetics. This article introduces
      perinatologists to the ethical principles of beneficence and respect for autonomy
      and uses these ethical principles to articulate the ethical concept of the fetus 
      as a patient. Together these constitute an ethical framework that we apply to
      risk assessment, in response to which women may be divided into four groups:
      prenatal genetic counseling, and the responsible management of pregnancies
      complicated by genetic anomalies of the fetus.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Chervenak, Frank A
AU  - Chervenak FA
AD  - Department of Obstetrics and Gynecology, New York Weill Cornell Medical Center,
      New York, New York, USA. fac2001@med.cornell.edu
FAU - McCullough, Laurence B
AU  - McCullough LB
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20101103
PL  - Netherlands
TA  - Semin Fetal Neonatal Med
JT  - Seminars in fetal & neonatal medicine
JID - 101240003
SB  - IM
MH  - Abortion, Induced/ethics
MH  - Female
MH  - *Fetus
MH  - Genetic Diseases, Inborn/*diagnosis
MH  - Genetic Testing/*ethics/*methods/psychology
MH  - Humans
MH  - Patient Rights/*ethics
MH  - *Personal Autonomy
MH  - Pregnancy
MH  - Prenatal Diagnosis/*ethics/*methods/psychology
EDAT- 2010/11/06 06:00
MHDA- 2011/07/02 06:00
CRDT- 2010/11/06 06:00
PHST- 2010/11/06 06:00 [entrez]
PHST- 2010/11/06 06:00 [pubmed]
PHST- 2011/07/02 06:00 [medline]
AID - S1744-165X(10)00091-0 [pii]
AID - 10.1016/j.siny.2010.10.004 [doi]
PST - ppublish
SO  - Semin Fetal Neonatal Med. 2011 Apr;16(2):70-3. doi: 10.1016/j.siny.2010.10.004.
      Epub 2010 Nov 3.


PMID- 21051292
OWN - NLM
STAT- MEDLINE
DCOM- 20110328
LR  - 20101129
IS  - 1472-6491 (Electronic)
IS  - 1472-6483 (Linking)
VI  - 21
IP  - 7
DP  - 2010 Dec
TI  - Religion, reproduction and public policy: disentangling morality from Catholic
      theology.
PG  - 834-7
LID - 10.1016/j.rbmo.2010.05.019 [doi]
AB  - Many people look to religion to help resolve the serious moral and legal issues
      associated with assisted reproductive technologies. Doing so presupposes that
      religion is the cornerstone of ethics, but this assumption is not well founded.
      While various faiths are entitled to articulate their views on matters of human
      reproduction, the contradictions involved in doing so make it unwise to rely on
      religion in the formulation of law and policy. These contradictions--such as the 
      indeterminacy about what revealed truths means--make moral secular philosophy a
      better guide for the protection of human welfare.
CI  - Copyright (c) 2010 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All
      rights reserved.
FAU - Dahl, Edgar
AU  - Dahl E
AD  - Institute of Medical Ethics, University of Muenster, Muenster, Germany.
      edgardahl@yahoo.com
LA  - eng
PT  - Journal Article
DEP - 20100616
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
SB  - IM
MH  - *Catholicism
MH  - Cultural Diversity
MH  - Ethical Relativism
MH  - Ethical Theory
MH  - Humans
MH  - *Morals
MH  - *Public Policy
MH  - *Religion and Medicine
MH  - Reproduction/*ethics
MH  - Reproductive Techniques, Assisted/ethics/legislation & jurisprudence
MH  - *Theology
EDAT- 2010/11/06 06:00
MHDA- 2011/03/29 06:00
CRDT- 2010/11/06 06:00
PHST- 2010/03/24 00:00 [received]
PHST- 2010/05/05 00:00 [revised]
PHST- 2010/05/26 00:00 [accepted]
PHST- 2010/11/06 06:00 [entrez]
PHST- 2010/11/06 06:00 [pubmed]
PHST- 2011/03/29 06:00 [medline]
AID - S1472-6483(10)00397-4 [pii]
AID - 10.1016/j.rbmo.2010.05.019 [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2010 Dec;21(7):834-7. doi: 10.1016/j.rbmo.2010.05.019. Epub
      2010 Jun 16.


PMID- 21051290
OWN - NLM
STAT- MEDLINE
DCOM- 20110328
LR  - 20101129
IS  - 1472-6491 (Electronic)
IS  - 1472-6483 (Linking)
VI  - 21
IP  - 7
DP  - 2010 Dec
TI  - Moral attitudes and beliefs among couples pursuing PGD for sex selection.
PG  - 838-47
LID - 10.1016/j.rbmo.2010.09.009 [doi]
AB  - This article reports the results from a study of couples participating in a
      research protocol in which IVF/preimplantation genetic diagnosis (PGD) was
      available for non-medical sex selection. The study sought to characterize the
      moral attitudes and beliefs of couples actively pursuing IVF/PGD solely for
      purposes related to sex selection. Eighteen couples participated in ethnographic 
      interviews from November 2005 to April 2006. These interviews explored couples'
      motivations for pursuing sex selection, moral beliefs and attitudes regarding sex
      selection and sources of moral ambivalence about the use of IVF/PGD for sex
      selection. Couples reported a combination of motivations for pursuing sex
      selection, including a desire to limit family size, concerns about parental age
      and financial concerns about multiple pregnancies. Many couples compared their
      decision to choices about abortion, maintaining that individuals have a right to 
      make such decisions privately. Couples frequently expressed anxiety about telling
      their other children and family members about their plans to use IVF/PGD for sex 
      selection. Few couples cited concerns about the physical or emotional burdens of 
      IVF/PGD. The study's findings suggest that couples pursuing IVF/PGD for sex
      selection view this as an ethically complex decision and express considerable
      uncertainty about the ethical acceptability of this practice.
CI  - Copyright (c) 2010 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All
      rights reserved.
FAU - Sharp, Richard R
AU  - Sharp RR
AD  - Department of Bioethics, Cleveland Clinic, Cleveland, OH, USA. sharpr3@ccf.org
FAU - McGowan, Michelle L
AU  - McGowan ML
FAU - Verma, Jonathan A
AU  - Verma JA
FAU - Landy, David C
AU  - Landy DC
FAU - McAdoo, Sallie
AU  - McAdoo S
FAU - Carson, Sandra A
AU  - Carson SA
FAU - Simpson, Joe Leigh
AU  - Simpson JL
FAU - McCullough, Laurence B
AU  - McCullough LB
LA  - eng
PT  - Journal Article
DEP - 20100926
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
SB  - IM
MH  - Adult
MH  - Confidentiality
MH  - Family Characteristics
MH  - Female
MH  - Fertilization in Vitro/economics/ethics/psychology
MH  - Health Care Costs
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Male
MH  - *Morals
MH  - Motivation
MH  - *Preimplantation Diagnosis/ethics/psychology
MH  - Reproductive Rights/ethics/psychology
MH  - Sex Preselection/*ethics/*psychology
MH  - Texas
EDAT- 2010/11/06 06:00
MHDA- 2011/03/29 06:00
CRDT- 2010/11/06 06:00
PHST- 2010/08/03 00:00 [received]
PHST- 2010/08/26 00:00 [revised]
PHST- 2010/09/07 00:00 [accepted]
PHST- 2010/11/06 06:00 [entrez]
PHST- 2010/11/06 06:00 [pubmed]
PHST- 2011/03/29 06:00 [medline]
AID - S1472-6483(10)00623-1 [pii]
AID - 10.1016/j.rbmo.2010.09.009 [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2010 Dec;21(7):838-47. doi: 10.1016/j.rbmo.2010.09.009.
      Epub 2010 Sep 26.


PMID- 21050821
OWN - NLM
STAT- MEDLINE
DCOM- 20110328
LR  - 20101129
IS  - 1472-6491 (Electronic)
IS  - 1472-6483 (Linking)
VI  - 21
IP  - 7
DP  - 2010 Dec
TI  - The moral status of the embryo: an attempt at an analysis with the aid of David
      Hume's ethics.
PG  - 830-3
LID - 10.1016/j.rbmo.2010.07.003 [doi]
AB  - This article applies the moral sentimentalism founded by David Hume to the moral 
      status of the embryo. It will attempt to explain the paradoxical fact that in
      Germany abortion is common and socially accepted while preimplantation genetic
      diagnosis is banned with the aid of an approach based on moral sentimentalism.
      David Hume established the thesis that the human being is guided by the emotions 
      and not by reason when making moral decisions. Scientific innovations often
      create a feeling of anxiety. Consequently, the initial moral judgment about it is
      negative. Due to this habit, the innovation is often accepted after a phase of
      indifference. This phenomenon has been observed in the case of heart
      transplantation, as well as for IVF. Consequently, the apparent contradiction in 
      the varying degrees of the embryo's worthiness of protection in the womb and in
      the Petri dish is due to the simple fact that these are different stages of
      habituation. Therefore, the ethics of Hume cannot stipulate the embryo's moral
      status for once and for all; however, they can paradoxically raise the ongoing
      current debate to a more rational level through the insight that the underlying
      moral concepts are not based on reason alone.
CI  - Copyright (c) 2010 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All
      rights reserved.
FAU - Engel, J B
AU  - Engel JB
AD  - Universitatsfrauenklinik Wurzburg, Josef-Schneider-Str. 4, 97080 Wurzburg,
      Germany. joergbengel@hotmail.com
FAU - Honig, A
AU  - Honig A
FAU - Segerer, S
AU  - Segerer S
FAU - Hausler, S F M
AU  - Hausler SF
FAU - Dietl, J
AU  - Dietl J
FAU - Djakovic, A
AU  - Djakovic A
LA  - eng
PT  - Journal Article
DEP - 20100718
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
SB  - IM
MH  - Bioethical Issues
MH  - Diffusion of Innovation
MH  - Embryo Research/*ethics
MH  - *Embryo, Mammalian
MH  - Ethical Theory
MH  - Germany
MH  - Humans
MH  - *Morals
MH  - Preimplantation Diagnosis/*ethics
MH  - Public Policy
EDAT- 2010/11/06 06:00
MHDA- 2011/03/29 06:00
CRDT- 2010/11/06 06:00
PHST- 2010/04/15 00:00 [received]
PHST- 2010/06/30 00:00 [revised]
PHST- 2010/07/06 00:00 [accepted]
PHST- 2010/11/06 06:00 [entrez]
PHST- 2010/11/06 06:00 [pubmed]
PHST- 2011/03/29 06:00 [medline]
AID - S1472-6483(10)00457-8 [pii]
AID - 10.1016/j.rbmo.2010.07.003 [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2010 Dec;21(7):830-3. doi: 10.1016/j.rbmo.2010.07.003. Epub
      2010 Jul 18.


PMID- 21050792
OWN - NLM
STAT- MEDLINE
DCOM- 20110325
LR  - 20161125
IS  - 1769-6682 (Electronic)
IS  - 1297-9589 (Linking)
VI  - 38
IP  - 11
DP  - 2010 Nov
TI  - [Fetal dysmorphology: a practical approach in utero].
PG  - 677-85
LID - 10.1016/j.gyobfe.2010.09.003 [doi]
AB  - Dysmorphology is the study of congenital malformations and anatomic variations of
      the individuals. Up to 2500 dysmorphic or malformative syndromes are described,
      most of them being characterized by mental retardation. Craniofacial
      dysmorphology may be the keystone of syndrome identification, although limb
      anomalies are sometimes important diagnostic clues. The advances of fetal
      imaging, particularly the development of 3D ultrasound techniques, allow a
      detailed analysis of the fetal face. Dysmorphology requires experience of rare
      syndromes and a perfect knowledge of normal facial appearance and variations. In 
      utero, this approach must combine the skills of both a practitioner with
      expertise in fetal ultrasound and a pediatric dysmorphologist. Furthermore,
      facial changes have to be analyzed according to the context of the pregnancy and 
      family history. Identification of patent facial anomalies may be a clue for the
      diagnosis of severe fetal syndromes and diseases. Conversely, when fetal
      malformations or abnomalities of the fetal growth are identified, a careful
      facial analysis can be proposed in order to rule out well-known syndromes with a 
      poor prognosis. However, from an ethical point of view, parents should not be
      aware of a possible facial dysmorphism unless there is a precise diagnosis and
      options concerning the pregnancy.
CI  - Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
FAU - Philip, N
AU  - Philip N
AD  - Departement de genetique medicale et centre de reference anomalies du
      developpement et syndromes malformatifs, hopital d'Enfants de Timone, 264, rue
      Saint-Pierre, 13385 Marseille cedex 5, France. nicole.philip@ap-hm.fr
FAU - Quarello, E
AU  - Quarello E
FAU - Gorincour, G
AU  - Gorincour G
FAU - Sigaudy, S
AU  - Sigaudy S
LA  - fre
PT  - Journal Article
TT  - Approche de la dysmorphologie foetale in utero.
DEP - 20101102
PL  - France
TA  - Gynecol Obstet Fertil
JT  - Gynecologie, obstetrique & fertilite
JID - 100936305
SB  - IM
MH  - Craniofacial Abnormalities/*diagnostic imaging/*pathology
MH  - Female
MH  - Fetus/*abnormalities/*pathology
MH  - Humans
MH  - Pregnancy
MH  - *Ultrasonography, Prenatal
EDAT- 2010/11/06 06:00
MHDA- 2011/03/26 06:00
CRDT- 2010/11/06 06:00
PHST- 2010/06/02 00:00 [received]
PHST- 2010/06/07 00:00 [accepted]
PHST- 2010/11/06 06:00 [entrez]
PHST- 2010/11/06 06:00 [pubmed]
PHST- 2011/03/26 06:00 [medline]
AID - S1297-9589(10)00295-X [pii]
AID - 10.1016/j.gyobfe.2010.09.003 [doi]
PST - ppublish
SO  - Gynecol Obstet Fertil. 2010 Nov;38(11):677-85. doi: 10.1016/j.gyobfe.2010.09.003.
      Epub 2010 Nov 2.


PMID- 21050789
OWN - NLM
STAT- MEDLINE
DCOM- 20110316
LR  - 20151119
IS  - 1953-8022 (Electronic)
IS  - 1246-7820 (Linking)
VI  - 17
IP  - 5-6
DP  - 2010 Dec
TI  - [Oncology blood transfusion and quality of life: review].
PG  - 357-61
LID - 10.1016/j.tracli.2010.09.162 [doi]
AB  - Blood transfusion's repercussions on quality of life are less well studied in
      cancer research, and rarer in palliative situation. It is necessary to look for
      studies dealing with anaemia to estimate its effects. In curative palliative
      situation, the situation is similar to that of curative stage patients. It is
      necessary landing quickly for anaemia to assure the patient's quality of life.
      Blood transfusion and more recently erythropoiesis-stimulating agents are
      effective treatments. In advanced palliative stage, transfusion improves symptoms
      (weakness and dyspnoea bound anaemia) and the patients' well being. The treatment
      choice must be individual and has to follow an ethical behaviour in respect with 
      the legislation.
CI  - Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
FAU - Poirier, A-L
AU  - Poirier AL
AD  - Centre d'Evaluation Clinique en Oncologie, Centre Paul-Papin, 2, rue Moll, 49933 
      Angers, France. al.poirier@angers.fnclcc.fr
FAU - Commer, J-M
AU  - Commer JM
FAU - Kwiatkowski, F
AU  - Kwiatkowski F
FAU - Mercier, M
AU  - Mercier M
FAU - Bonnetain, F
AU  - Bonnetain F
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Qualite de vie et transfusion en cancerologie: revue de la litterature.
DEP - 20101102
PL  - France
TA  - Transfus Clin Biol
JT  - Transfusion clinique et biologique : journal de la Societe francaise de
      transfusion sanguine
JID - 9423846
RN  - 0 (Hematinics)
SB  - IM
MH  - Anemia/drug therapy/etiology/*therapy
MH  - *Blood Transfusion/ethics/legislation & jurisprudence/psychology
MH  - Dyspnea/etiology/therapy
MH  - Hematinics/therapeutic use
MH  - Humans
MH  - Neoplasms/*complications
MH  - Palliative Care
MH  - Patient Acceptance of Health Care
MH  - *Quality of Life
MH  - Surveys and Questionnaires
MH  - Terminal Care
EDAT- 2010/11/06 06:00
MHDA- 2011/03/17 06:00
CRDT- 2010/11/06 06:00
PHST- 2010/08/22 00:00 [received]
PHST- 2010/09/01 00:00 [accepted]
PHST- 2010/11/06 06:00 [entrez]
PHST- 2010/11/06 06:00 [pubmed]
PHST- 2011/03/17 06:00 [medline]
AID - S1246-7820(10)00273-9 [pii]
AID - 10.1016/j.tracli.2010.09.162 [doi]
PST - ppublish
SO  - Transfus Clin Biol. 2010 Dec;17(5-6):357-61. doi: 10.1016/j.tracli.2010.09.162.
      Epub 2010 Nov 2.


PMID- 21050512
OWN - NLM
STAT- MEDLINE
DCOM- 20110606
LR  - 20191111
IS  - 1701-2163 (Print)
IS  - 1701-2163 (Linking)
VI  - 32
IP  - 8
DP  - 2010 Aug
TI  - Multicentre study on factors affecting the gynaecologic oncology career choice of
      canadian residents in obstetrics and gynaecology.
PG  - 780-93
AB  - INTRODUCTION: The provision of optimal care for women with gynaecologic cancer
      may be threatened due to the changing demographics of patients and the projected 
      increasing shortage of gynaecologic oncologists in Canada. We evaluated the
      career plans of Canadian residents in obstetrics and gynaecology to determine the
      proportion of residents currently considering a career in gynaecologic oncology
      (GO) and to explore factors that may affect their career decisions. METHODS:
      Following institutional ethics approval, all residents at 13 participating
      Canadian obstetrics and gynaecology residency training programs were contacted by
      email to complete a 20-item confidential questionnaire examining career plans.
      Quantitative data were analyzed using SAS v9.1. Qualitative data were coded by
      theme and grouped into various domains. RESULTS: Of 293 residents, 105 (36%)
      participated. More than half of these were considering at least one obstetrics
      and gynaecology subspecialty, but 53% indicated that their most appealing career 
      path was general obstetrics and gynaecology. Although 50% of residents had ever
      considered a career in GO, only 17% were considering a GO career at the time of
      the survey. When rated as positive influences, medical school exposure, resident 
      exposure, role models within GO, colleagues, other health care professionals, "my
      individual life circumstances," "my personal attributes," the clinical, research,
      and educational components of GO, the GO patient population, and relation with
      gynaecologic oncologists and other specialists were significant predictors of
      current GO interest. Themes that emerged from qualitative analysis revealed that 
      the clinical, professional, and research domains were predominant influences
      among residents currently considering a career in GO. CONCLUSIONS: GO is an
      infrequent career choice for Canadian residents in obstetrics and gynaecology,
      and a number of factors significantly affect GO career decisions. Modifying
      factors such as educational experiences, work environment, and current practice
      models may lead to improved recruitment to the subspecialty, which is crucial for
      meeting the future needs of women with gynaecologic malignancies in Canada.
FAU - Dodge, Jason E
AU  - Dodge JE
AD  - Division of Gynaecologic Oncology, Princess Margaret Hospital, University Health 
      Network, Department of Obstetrics and Gynaecology, University of Toronto, Toronto
      ON, Canada.
FAU - Chiu, Hannah H
AU  - Chiu HH
FAU - Fung, Sharon
AU  - Fung S
FAU - Rosen, Barry P
AU  - Rosen BP
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - Netherlands
TA  - J Obstet Gynaecol Can
JT  - Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et
      gynecologie du Canada : JOGC
JID - 101126664
SB  - IM
MH  - Adult
MH  - Canada
MH  - *Career Choice
MH  - Female
MH  - Gynecology/*education
MH  - Humans
MH  - *Internship and Residency
MH  - Male
MH  - Medical Oncology/*education
MH  - Middle Aged
MH  - Obstetrics/*education
EDAT- 2010/11/06 06:00
MHDA- 2011/06/07 06:00
CRDT- 2010/11/06 06:00
PHST- 2010/11/06 06:00 [entrez]
PHST- 2010/11/06 06:00 [pubmed]
PHST- 2011/06/07 06:00 [medline]
AID - S1701-2163(16)34621-7 [pii]
AID - 10.1016/s1701-2163(16)34621-7 [doi]
PST - ppublish
SO  - J Obstet Gynaecol Can. 2010 Aug;32(8):780-93. doi: 10.1016/s1701-2163(16)34621-7.


PMID- 21050461
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1746-1340 (Electronic)
IS  - 1746-1340 (Linking)
VI  - 18
DP  - 2010 Nov 4
TI  - Attitudes of non-practicing chiropractors: a pilot survey concerning factors
      related to attrition.
PG  - 29
LID - 10.1186/1746-1340-18-29 [doi]
AB  - BACKGROUND: Research into attitudes about chiropractors who are no longer engaged
      in active clinical practice is non-existent. Yet non-practicing chiropractors
      (NPCs) represent a valid sub-group worthy of study. AIM: The purpose of this
      research was to assess attrition attitudes of NPCs about the chiropractic
      profession and develop a scale to assess such attitudes. METHODS: A 48 item
      survey was developed using the PsychData software. This survey included 35
      Likert-style items assessing various aspects of the profession namely financial, 
      educational, psychosocial and political. An internet discussion site where NPCs
      may be members was accessed for recruitment purposes. RESULTS: A total of 70
      valid responses were received for analysis. A majority of respondents were male
      with 66% being in non-practice status for 3 to 5 years and less with 43%
      indicating that they had graduated since the year 2000. Most respondents were
      employed either in other healthcare professions and non-chiropractic education. A
      majority of NPCs believed that business ethics in chiropractic were questionable 
      and that overhead expense and student loans were factors in practice success. A
      majority of NPCs were in associate practice at one time with many believing that 
      associates were encouraged to prolong the care of patients and that associate
      salaries were not fair. Most NPCs surveyed believed that chiropractic was not a
      good career choice and would not recommend someone to become a chiropractor. From
      this survey, a 12 item scale was developed called the "chiropractor attrition
      attitude scale" for future research. Reliability analysis of this novel scale
      demonstrated a coefficient alpha of 0.90. CONCLUSION: The low response rate
      indicates that findings cannot be generalized to the NPC population. This study
      nonetheless demonstrates that NPCs attrition attitudes can be assessed. The lack 
      of a central database of NPCs is a challenge to future research. Appropriate
      investigation of attrition within the chiropractic profession would be helpful in
      the analysis of attitudes regarding both chiropractic education and practice.
      Further research is needed in this area.
FAU - Mirtz, Timothy A
AU  - Mirtz TA
AD  - Division of Health, Physical Education and Recreation, 414 East Clark
      Street--Dome 221B, University of South Dakota, Vermillion, South Dakota, 57069,
      USA. timothy.mirtz@usd.edu.
FAU - Hebert, Jeffrey J
AU  - Hebert JJ
FAU - Wyatt, Lawrence H
AU  - Wyatt LH
LA  - eng
PT  - Journal Article
DEP - 20101104
PL  - England
TA  - Chiropr Osteopat
JT  - Chiropractic & osteopathy
JID - 101245797
PMC - PMC2992535
EDAT- 2010/11/06 06:00
MHDA- 2010/11/06 06:01
CRDT- 2010/11/06 06:00
PHST- 2010/06/25 00:00 [received]
PHST- 2010/11/04 00:00 [accepted]
PHST- 2010/11/06 06:00 [entrez]
PHST- 2010/11/06 06:00 [pubmed]
PHST- 2010/11/06 06:01 [medline]
AID - 1746-1340-18-29 [pii]
AID - 10.1186/1746-1340-18-29 [doi]
PST - epublish
SO  - Chiropr Osteopat. 2010 Nov 4;18:29. doi: 10.1186/1746-1340-18-29.


PMID- 21050452
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1753-2000 (Electronic)
IS  - 1753-2000 (Linking)
VI  - 4
DP  - 2010 Nov 4
TI  - Methodological challenges in following up patients of a hospital child protection
      team: is there a recruitment bias?
PG  - 27
LID - 10.1186/1753-2000-4-27 [doi]
AB  - BACKGROUND: The aims of this study are to describe the methodological challenges 
      in recruiting a follow-up sample of children referred to an interdisciplinary
      hospital child protection team (CPT) and to compare participating versus
      non-participating groups on several demographic variables and maltreatment
      characteristics. METHODS: Of the 319 in- and outpatients referred to the CPT at
      University Children's Hospital Zurich from 2005-2006 a sample of 180 children was
      drawn to contact for a follow-up. The children and their parents were asked to
      participate in a face-to-face interview at the hospital; in 42 cases the children
      and parents consented to do so. Alternatively, the parents could take part in a
      telephone interview (n = 39). Non-participation resulted because no contact or
      adequate communication in German, French, or English could be established (n =
      49) or because the parents or children refused to participate (n = 50). RESULTS: 
      Participants and non-participants did not differ significantly in mean child age 
      at follow-up, gender, family status, place of residence, certainty and type of
      maltreatment, and type of perpetrator. However, the child's nationality had a
      significant impact: Percentages of foreign nationals were higher in the fully
      participating group (45%; n = 19) and the non-contactable group (53%; n = 26) and
      significantly lower in the refusal (26%; n = 10) and the telephone interview
      group (18%; n = 9). Although a high percentage of families had moved in the few
      years since the CPT intervention (32%; n = 57), the percentage of moves was not
      significantly higher in non-participants compared to participants. CONCLUSIONS:
      Further research is needed to support these results in different national
      backgrounds and to test for biases in variables not included - especially
      socioeconomic status. This includes gathering more detailed information on
      non-participants, while respecting ethical boundaries. Overall, the fact that
      only child's nationality was unevenly distributed between participants and
      non-participants is encouraging.
FAU - Jud, Andreas
AU  - Jud A
AD  - University Children's Hospital Zurich, Steinwiesstrasse 75, 8032 Zurich,
      Switzerland. andreas.jud@kispi.uzh.ch.
FAU - Lips, Ulrich
AU  - Lips U
FAU - Landolt, Markus A
AU  - Landolt MA
LA  - eng
PT  - Journal Article
DEP - 20101104
PL  - England
TA  - Child Adolesc Psychiatry Ment Health
JT  - Child and adolescent psychiatry and mental health
JID - 101297974
PMC - PMC2989303
EDAT- 2010/11/06 06:00
MHDA- 2010/11/06 06:01
CRDT- 2010/11/06 06:00
PHST- 2010/08/20 00:00 [received]
PHST- 2010/11/04 00:00 [accepted]
PHST- 2010/11/06 06:00 [entrez]
PHST- 2010/11/06 06:00 [pubmed]
PHST- 2010/11/06 06:01 [medline]
AID - 1753-2000-4-27 [pii]
AID - 10.1186/1753-2000-4-27 [doi]
PST - epublish
SO  - Child Adolesc Psychiatry Ment Health. 2010 Nov 4;4:27. doi:
      10.1186/1753-2000-4-27.


PMID- 21050395
OWN - NLM
STAT- MEDLINE
DCOM- 20110329
LR  - 20191210
IS  - 1743-6109 (Electronic)
IS  - 1743-6095 (Linking)
VI  - 7
IP  - 9
DP  - 2010 Sep
TI  - Experimental models for the study of female and male sexual function.
PG  - 2970-95
LID - 10.1111/j.1743-6109.2010.01960.x [doi]
AB  - INTRODUCTION: Significant progress has been made in the understanding of
      physiological and pharmacological mechanisms of human sexual functioning through 
      preclinical research in animal models. AIM: To provide an evidence-based
      documentation of the experimental models evaluating male and female sexual
      function for useful clinical translation. METHODS: Consensus discussion over the 
      past 18 months leading to summarized views of seven experts from six countries.
      MAIN OUTCOME MEASURE: Report was based on the critical analysis of scientific
      information available in literature and subcommittee presentations, discussions, 
      and exchanges of ideas and feedback. RESULTS: Fundamental research in animal
      models has led to considerable understanding of the physiological mechanisms
      underlying desire, arousal, genital, and other sexual responses and the design of
      rational pharmacological treatments for certain sexual dysfunctions in the male
      and female. Tissue and cellular in vitro systems have provided critical
      information on the in vivo interactions and modulations in the presence and
      absence of chemical, biological, vascular, neurologic, endocrine, and genetic
      inputs. The animal models seem indispensable for elucidating the biophysiological
      and etiopathological aspects of male and female sexual disorders. CONCLUSIONS:
      Useful insights into the human experience have been derived from basic research
      in ways that are far more difficult to obtain in humans, both scientifically and 
      ethically. The animal model with a good predictive value can be used as a
      successful preclinical tool so long as the functional end points are homologous
      or analogous. The key issue is whether further evaluations are warranted to
      extrapolate the results in a clinical setting.
CI  - (c) 2010 International Society for Sexual Medicine.
FAU - Giuliano, Francois
AU  - Giuliano F
AD  - Raymond Poincare Hospital, Department of Physical Medicine and Rehabilitation,
      Garches, France. giuliano@cyber-sante.org
FAU - Pfaus, James
AU  - Pfaus J
FAU - Srilatha, Balasubramanian
AU  - Srilatha B
FAU - Hedlund, Petter
AU  - Hedlund P
FAU - Hisasue, Shin-ichi
AU  - Hisasue S
FAU - Marson, Lesley
AU  - Marson L
FAU - Wallen, Kim
AU  - Wallen K
LA  - eng
PT  - Consensus Development Conference
PT  - Journal Article
PL  - Netherlands
TA  - J Sex Med
JT  - The journal of sexual medicine
JID - 101230693
RN  - 0 (Anesthetics)
RN  - 0 (Gonadal Steroid Hormones)
SB  - IM
EIN - J Sex Med. 2010 Nov;7(11):3804. Balasubramanian, Srilatha [corrected to Srilatha,
      Balasubramanian]
MH  - Aging/physiology
MH  - Anesthetics/pharmacology
MH  - Animals
MH  - Arousal/*physiology
MH  - Autonomic Nervous System/physiology
MH  - Blood Pressure/physiology
MH  - Consciousness
MH  - Copulation/physiology
MH  - Electric Stimulation
MH  - Female
MH  - Gonadal Steroid Hormones/blood
MH  - Humans
MH  - Inhibition, Psychological
MH  - Libido/physiology
MH  - Male
MH  - *Models, Animal
MH  - Penis/innervation/metabolism/*physiology
MH  - Rats
MH  - Reproduction/*physiology
MH  - Seminal Vesicles/physiology
MH  - Sexual Dysfunction, Physiological/physiopathology
MH  - Sexuality/physiology
MH  - Substance-Related Disorders/physiopathology
MH  - Vagina/innervation/metabolism/*physiology
MH  - Vas Deferens/physiology
EDAT- 2010/11/06 06:00
MHDA- 2011/03/30 06:00
CRDT- 2010/11/06 06:00
PHST- 2010/11/06 06:00 [entrez]
PHST- 2010/11/06 06:00 [pubmed]
PHST- 2011/03/30 06:00 [medline]
AID - 10.1111/j.1743-6109.2010.01960.x [doi]
AID - S1743-6095(15)33156-8 [pii]
PST - ppublish
SO  - J Sex Med. 2010 Sep;7(9):2970-95. doi: 10.1111/j.1743-6109.2010.01960.x.


PMID- 21050334
OWN - NLM
STAT- MEDLINE
DCOM- 20110311
LR  - 20151119
IS  - 1365-2850 (Electronic)
IS  - 1351-0126 (Linking)
VI  - 17
IP  - 8
DP  - 2010 Oct
TI  - An exploration of mental health nursing students' experiences and attitudes
      towards using cigarettes to change client's behaviour.
PG  - 683-91
LID - 10.1111/j.1365-2850.2010.01605.x [doi]
AB  - Using cigarettes to change client behaviour is a common, yet little studied,
      practice in mental health care. A questionnaire survey was used to explore mental
      health nursing student's experiences and attitudes to this practice. The sample
      was four cohorts of mental health nursing students (n= 151). Of them, 84% had
      experienced the practice of using cigarettes to change client behaviour in acute 
      wards (73%), rehabilitation wards (28%) and elderly care (14%). Cigarettes were
      used to change client behaviour in areas such as attending to personal hygiene
      (57%) or engaging in the ward routine (39%). However, items such as leave (60%)
      or drinks (tea and coffee) (38%) were also reportedly used. Of the respondents,
      54% inferred that the practice did not work well with 46% stating it was not
      written up in care plans; 52% felt it was an ad hoc practice, 60% inferred that
      at times it was used as a punishment while 55% intimated that they felt bad
      withholding cigarettes. There are ethical and moral dilemmas around using
      lifestyle risk factors as rewards or using client's nicotine addiction as a means
      of controlling behaviour. The question of whether this intervention should ever
      be used, given its associated health risk, requires more critical debate in
      clinical practice.
CI  - (c) 2010 Blackwell Publishing.
FAU - Nash, M J
AU  - Nash MJ
AD  - Psychiatric Nursing, School of Nursing and Midwifery, Trinity College Dublin
      Consultant Forensic Psychiatrist, St Brendan's Hospital, Dublin, Ireland.
      michael.nash@tcd.ie
FAU - Romanos, M T
AU  - Romanos MT
LA  - eng
PT  - Journal Article
DEP - 20100708
PL  - England
TA  - J Psychiatr Ment Health Nurs
JT  - Journal of psychiatric and mental health nursing
JID - 9439514
MH  - *Attitude of Health Personnel
MH  - Behavior Therapy/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Mental Disorders/psychology/rehabilitation/*therapy
MH  - Motivation
MH  - Psychiatric Nursing/*education
MH  - Smoking/*psychology
MH  - Students, Nursing/*psychology
MH  - Surveys and Questionnaires
MH  - Token Economy
EDAT- 2010/11/06 06:00
MHDA- 2011/03/12 06:00
CRDT- 2010/11/06 06:00
PHST- 2010/11/06 06:00 [entrez]
PHST- 2010/11/06 06:00 [pubmed]
PHST- 2011/03/12 06:00 [medline]
AID - 10.1111/j.1365-2850.2010.01605.x [doi]
PST - ppublish
SO  - J Psychiatr Ment Health Nurs. 2010 Oct;17(8):683-91. doi:
      10.1111/j.1365-2850.2010.01605.x. Epub 2010 Jul 8.


PMID- 21050246
OWN - NLM
STAT- MEDLINE
DCOM- 20110310
LR  - 20181201
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 24
IP  - 8
DP  - 2010 Oct
TI  - Why the Avandia scandal proves big pharma needs stronger ethical standards.
PG  - ii-iii
LID - 10.1111/j.1467-8519.2010.01855.x [doi]
FAU - Philpott, Sean
AU  - Philpott S
FAU - Baker, Robert
AU  - Baker R
LA  - eng
PT  - Editorial
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Thiazolidinediones)
RN  - 05V02F2KDG (Rosiglitazone)
SB  - IM
MH  - Cardiovascular Diseases/*chemically induced
MH  - Drug Evaluation
MH  - Drug Industry/*ethics
MH  - Drug and Narcotic Control
MH  - Humans
MH  - Hypoglycemic Agents/*adverse effects
MH  - Rosiglitazone
MH  - Thiazolidinediones/*adverse effects
MH  - Trust
MH  - *Truth Disclosure/ethics
MH  - United States
EDAT- 2010/11/06 06:00
MHDA- 2011/03/11 06:00
CRDT- 2010/11/06 06:00
PHST- 2010/11/06 06:00 [entrez]
PHST- 2010/11/06 06:00 [pubmed]
PHST- 2011/03/11 06:00 [medline]
AID - 10.1111/j.1467-8519.2010.01855.x [doi]
PST - ppublish
SO  - Bioethics. 2010 Oct;24(8):ii-iii. doi: 10.1111/j.1467-8519.2010.01855.x.


PMID- 21050225
OWN - NLM
STAT- MEDLINE
DCOM- 20101206
LR  - 20211203
IS  - 1537-2995 (Electronic)
IS  - 0041-1132 (Linking)
VI  - 50
IP  - 9
DP  - 2010 Sep
TI  - Blood banks, biobanks, and the ethics of donation.
PG  - 1866-9
LID - 10.1111/j.1537-2995.2010.02812.x [doi]
FAU - Mitchell, Robert
AU  - Mitchell R
LA  - eng
PT  - Editorial
PT  - Comment
PL  - United States
TA  - Transfusion
JT  - Transfusion
JID - 0417360
SB  - IM
CON - Transfusion. 2010 Sep;50(9):1943-50. PMID: 20456705
CON - Transfusion. 2010 Sep;50(9):1951-8. PMID: 20561291
CIN - Transfusion. 2011 May;51(5):1123-5; author reply 1125. PMID: 21545597
MH  - Adolescent
MH  - Adult
MH  - African Americans
MH  - Aged
MH  - Asians
MH  - Blood Banks/*statistics & numerical data
MH  - Blood Donors/*psychology/statistics & numerical data
MH  - Blood Preservation/ethics/*psychology/statistics & numerical data
MH  - Cross-Sectional Studies
MH  - Female
MH  - Genetic Research
MH  - Hispanic or Latino
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Surveys and Questionnaires
MH  - Whites
MH  - Young Adult
EDAT- 2010/11/06 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/11/06 06:00
PHST- 2010/11/06 06:00 [entrez]
PHST- 2010/11/06 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1111/j.1537-2995.2010.02812.x [doi]
PST - ppublish
SO  - Transfusion. 2010 Sep;50(9):1866-9. doi: 10.1111/j.1537-2995.2010.02812.x.


PMID- 21050200
OWN - NLM
STAT- MEDLINE
DCOM- 20110303
LR  - 20101105
IS  - 1466-7657 (Electronic)
IS  - 0020-8132 (Linking)
VI  - 57
IP  - 4
DP  - 2010 Dec
TI  - The influence of personality traits on nurses' job satisfaction in Taiwan.
PG  - 478-84
LID - 10.1111/j.1466-7657.2010.00825.x [doi]
AB  - AIM: The purpose of this study was to empirically investigate a set of
      personality traits based on core self-evaluations in relation to job satisfaction
      among nurses in Taiwan, and to identity important personality characteristics in 
      contributing to nurses' satisfactory attitudes towards work. METHOD: A
      cross-sectional survey research was conducted with self-reported questionnaires. 
      The participants were 314 nurses (89% response rate) in two regional hospitals in
      Taiwan. Among them, 99% were female (n=311), 54.5% (n=171) ranging between 21 and
      30 years old, 37.9% (n=119) ranging between 31 and 40 years old, 44.6% (n=140)
      are registered nurse, 29.3% (n=92) are licensed vocational nurse and 52.9% were
      married (n=166). In addition, ethical research requirements for conducting
      research on human subjects were fulfilled for all of the participants in the
      study. ANALYSIS: Data were analysed using SPSS version 14.0 software (SPSS Inc., 
      Chicago, IL, USA). A number of data analysis procedures were conducted including 
      descriptive statistics, Pearson product-moment correlation and multiple
      regression analysis. The selection of the predictor variables was performed with 
      the level of significance P<0.05 and the adjusted explained variance was used to 
      examine statistical explanatory power. RESULTS: Personality traits of optimism,
      self-esteem, proactive personality, self-efficacy and negative affectivity
      significantly contributed to job satisfaction. CONCLUSIONS: The findings of this 
      study confirmed the importance of taking personality variables into consideration
      during the process of evaluating job satisfaction. Job satisfaction should not
      only be related to extrinsic factors but also associated with individual
      differences of dispositional tendency. Nurses with positive evaluation and
      expectation towards self and others tend to report higher job satisfaction. The
      results of this study are consistent with previous studies. The implications for 
      nursing managements are discussed.
CI  - (c) 2010 The Authors. International Nursing Review (c) 2010 International Council
      of Nurses.
FAU - Chang, Y H
AU  - Chang YH
AD  - Yuan Ze University, ChungLi, Taiwan.
FAU - Li, H-H
AU  - Li HH
FAU - Wu, C M
AU  - Wu CM
FAU - Wang, P C
AU  - Wang PC
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20100914
PL  - England
TA  - Int Nurs Rev
JT  - International nursing review
JID - 7808754
SB  - IM
MH  - Adult
MH  - Attitude of Health Personnel
MH  - Cross-Sectional Studies
MH  - Emotions
MH  - Female
MH  - Humans
MH  - *Job Satisfaction
MH  - Male
MH  - Nurses/*psychology
MH  - *Personality
MH  - Regression Analysis
MH  - Self Concept
MH  - Taiwan
EDAT- 2010/11/06 06:00
MHDA- 2011/03/04 06:00
CRDT- 2010/11/06 06:00
PHST- 2010/11/06 06:00 [entrez]
PHST- 2010/11/06 06:00 [pubmed]
PHST- 2011/03/04 06:00 [medline]
AID - 10.1111/j.1466-7657.2010.00825.x [doi]
PST - ppublish
SO  - Int Nurs Rev. 2010 Dec;57(4):478-84. doi: 10.1111/j.1466-7657.2010.00825.x. Epub 
      2010 Sep 14.


PMID- 21049870
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20190918
IS  - 1051-0761 (Print)
IS  - 1051-0761 (Linking)
VI  - 20
IP  - 7
DP  - 2010 Oct
TI  - Move it or lose it? The ecological ethics of relocating species under climate
      change.
PG  - 1801-4
AB  - Managed relocation (also known as assisted colonization, assisted migration) is
      one of the more controversial proposals to emerge in the ecological community in 
      recent years. A conservation strategy involving the translocation of species to
      novel ecosystems in anticipation of range shifts forced by climate change,
      managed relocation (MR) has divided many ecologists and conservationists, mostly 
      because of concerns about the potential invasion risk of the relocated species in
      their new environments. While this is indeed an important consideration in any
      evaluation of MR, moving species across the landscape in response to predicted
      climate shifts also raises a number of larger and important ethical and policy
      challenges that need to be addressed. These include evaluating the implications
      of a more aggressive approach to species conservation, assessing MR as a broader 
      ecological policy and philosophy that departs from longstanding scientific and
      management goals focused on preserving ecological integrity, and considering MR
      within a more comprehensive ethical and policy response to climate change. Given 
      the complexity and novelty of many of the issues at stake in the MR debate, a
      more dynamic and pragmatic approach to ethical analysis and debate is needed to
      help ecologists, conservationists, and environmental decision makers come to
      grips with MR and the emerging ethical challenges of ecological policy and
      management under global environmental change.
FAU - Minteer, Ben A
AU  - Minteer BA
AD  - School of Life Sciences, Arizona State University, Tempe, Arizona 85287-4501,
      USA. ben.minteer@asu.edu
FAU - Collins, James P
AU  - Collins JP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Ecol Appl
JT  - Ecological applications : a publication of the Ecological Society of America
JID - 9889808
SB  - IM
MH  - Animals
MH  - *Bioethical Issues
MH  - *Climate Change
MH  - Conservation of Natural Resources/*methods
MH  - *Ecosystem
MH  - Environmental Policy
MH  - Extinction, Biological
EDAT- 2010/11/06 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/11/06 06:00
PHST- 2010/11/06 06:00 [entrez]
PHST- 2010/11/06 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1890/10-0318.1 [doi]
PST - ppublish
SO  - Ecol Appl. 2010 Oct;20(7):1801-4. doi: 10.1890/10-0318.1.


PMID- 21048880
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 2374-250X (Electronic)
IS  - 1042-5055 (Linking)
VI  - 24
IP  - 2
DP  - 2010 Fall
TI  - Development of the murdoch chiropractic graduate pledge.
PG  - 175-86
AB  - PURPOSE: This paper reviews the origins of the learned professions, the
      foundational concepts of professionalism, and the common elements within various 
      healer's oaths. It then reveals the development of the Murdoch Chiropractic
      Graduate Pledge. METHODS: A committee comprised of three Murdoch academics
      performed literature searches on the topic of professionalism and healer's oaths 
      and utilized the Quaker consensus process to develop the Murdoch Chiropractic
      Graduate Pledge. RESULTS: The committee in its deliberations utilized over 200
      relevant papers and textbooks to formulate the Murdoch Chiropractic Graduate
      Pledge that was administered to the 2010 Murdoch School of Chiropractic and
      Sports Science graduates. The School of Chiropractic and Sports Science included 
      professionalism as one of its strategic goals and began the process of curriculum
      review to align it with the goal of providing a curriculum that recognizes and
      emphasizes the development of professionalism. CONCLUSIONS: The reciting of a
      healer's oath such as the Hippocratic Oath is widely considered to be the first
      step in a new doctor's career. It is seen as the affirmation that a newly trained
      health care provider will use his or her newfound knowledge and skill exclusively
      for the benefit of mankind in an ethical manner. Born from the very meaning of
      the word profession, the tradition of recitation of a healer's oath is resurgent 
      in health care. It is important for health care instructors to understand that
      the curriculum must be such that it contributes positively to the students'
      professional development.
FAU - Simpson, J Keith
AU  - Simpson JK
AD  - Murdoch University School of Chiropractic and Sports Science.
FAU - Losco, Barrett
AU  - Losco B
FAU - Young, Kenneth J
AU  - Young KJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Chiropr Educ
JT  - The Journal of chiropractic education
JID - 8915779
PMC - PMC2967342
OTO - NOTNLM
OT  - Chiropractic
OT  - Education
OT  - Ethical Oaths
OT  - Professional
EDAT- 2010/11/05 06:00
MHDA- 2010/11/05 06:01
CRDT- 2010/11/05 06:00
PHST- 2010/03/08 00:00 [received]
PHST- 2010/06/10 00:00 [revised]
PHST- 2010/06/20 00:00 [revised]
PHST- 2010/06/21 00:00 [accepted]
PHST- 2010/11/05 06:00 [entrez]
PHST- 2010/11/05 06:00 [pubmed]
PHST- 2010/11/05 06:01 [medline]
AID - 10.7899/1042-5055-24.2.175 [doi]
PST - ppublish
SO  - J Chiropr Educ. 2010 Fall;24(2):175-86. doi: 10.7899/1042-5055-24.2.175.


PMID- 21048439
OWN - NLM
STAT- MEDLINE
DCOM- 20110329
LR  - 20101104
IS  - 1532-5520 (Electronic)
IS  - 0009-9201 (Linking)
VI  - 53
IP  - 4
DP  - 2010 Dec
TI  - Ethical issues surrounding fertility preservation in cancer patients.
PG  - 717-26
LID - 10.1097/GRF.0b013e3181f96a70 [doi]
AB  - Fertility preservation is a newly developed branch of reproductive medicine aimed
      at preserving the potential for genetic parenthood in adults of reproductive age 
      or children, who are at risk of sterility before undergoing anticancer
      treatments. Except for embryo and semen freezing, all the available options to
      preserve fertility are considered experimental and thus, they raise ethical
      issues. In this study, we reviewed the informed consent and the risk-benefit
      analysis of offering experimental procedures for both adults and children when
      they are in vulnerable situations. In particular, children represent a special
      category of patients and their assent to treatment to be sought at anytime should
      be possible. Overall, there should be no ethical objections to offer these
      services as they are offered with the scope of preserving future fertility.
FAU - Patrizio, Pasquale
AU  - Patrizio P
AD  - Yale University Fertility Center, New Haven, Connecticut 06511, USA.
      pasquale.patrizio@yale.edu
FAU - Caplan, Arthur L
AU  - Caplan AL
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Clin Obstet Gynecol
JT  - Clinical obstetrics and gynecology
JID - 0070014
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Antineoplastic Agents/adverse effects
MH  - Cryopreservation
MH  - Female
MH  - *Fertility
MH  - Health Status
MH  - Humans
MH  - Infertility/etiology/prevention & control
MH  - Informed Consent
MH  - Male
MH  - Medical Oncology/*ethics
MH  - Neoplasms/*complications/therapy
MH  - Oocytes/physiology
MH  - Pregnancy
MH  - Pregnancy Outcome
MH  - Radiotherapy/adverse effects
MH  - Semen Preservation
MH  - Stem Cell Research
EDAT- 2010/11/05 06:00
MHDA- 2011/03/30 06:00
CRDT- 2010/11/05 06:00
PHST- 2010/11/05 06:00 [entrez]
PHST- 2010/11/05 06:00 [pubmed]
PHST- 2011/03/30 06:00 [medline]
AID - 10.1097/GRF.0b013e3181f96a70 [doi]
AID - 00003081-201012000-00003 [pii]
PST - ppublish
SO  - Clin Obstet Gynecol. 2010 Dec;53(4):717-26. doi: 10.1097/GRF.0b013e3181f96a70.


PMID- 21048238
OWN - NLM
STAT- MEDLINE
DCOM- 20110223
LR  - 20191210
IS  - 0974-7559 (Electronic)
IS  - 0019-6061 (Linking)
VI  - 47
IP  - 10
DP  - 2010 Oct
TI  - Advertisement of food products for children: a tale of legality, ethics and
      indifference.
PG  - 857-9
FAU - Vashishtha, Vipin M
AU  - Vashishtha VM
AD  - Mangla Hospital, Bijnor - 246 701, UP, India. vmv@manglahospital.org
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian Pediatr
JT  - Indian pediatrics
JID - 2985062R
SB  - IM
CIN - Indian Pediatr. 2011 May;48(5):413-5. PMID: 21654018
MH  - Advertising/*ethics/legislation & jurisprudence
MH  - Child
MH  - *Child Welfare
MH  - Food
MH  - Food Industry/*ethics
MH  - Humans
MH  - India
EDAT- 2010/11/05 06:00
MHDA- 2011/02/24 06:00
CRDT- 2010/11/05 06:00
PHST- 2010/11/05 06:00 [entrez]
PHST- 2010/11/05 06:00 [pubmed]
PHST- 2011/02/24 06:00 [medline]
AID - 10.1007/s13312-010-0141-z [doi]
PST - ppublish
SO  - Indian Pediatr. 2010 Oct;47(10):857-9. doi: 10.1007/s13312-010-0141-z.


PMID- 21048064
OWN - NLM
STAT- MEDLINE
DCOM- 20110711
LR  - 20101104
IS  - 1943-5657 (Electronic)
IS  - 0033-8397 (Linking)
VI  - 82
IP  - 2
DP  - 2010 Nov-Dec
TI  - Domestic violence.
PG  - 133-53
AB  - Domestic violence is a neglected epidemic in the United States that affects
      millions of children and adults and leads to a sizable proportion of emergency
      department visits--and possibly the majority of nonfatal injuries among women.
      Health care encounters represent the most promising opportunities for identifying
      victims and intervening in patterns of abuse, and all health care professionals
      have an ethical obligation to help identify cases of abuse. In this Directed
      Reading, the epidemiology and outcomes of domestic violence are introduced,
      screening methods and reporting requirements are reviewed, and the roles of
      diagnostic imaging in detecting and characterizing frequently neglected but
      common domestic violence injuries are discussed. This article is a Directed
      Reading. Your access to Directed Reading quizzes for continuing education credit 
      is determined by your area of interest. For access to other quizzes, go to
      www.asrt.org/store.
FAU - Furlow, Bryant
AU  - Furlow B
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Radiol Technol
JT  - Radiologic technology
JID - 0401256
SB  - IM
CIN - Radiol Technol. 2011 Mar-Apr;82(4):381. PMID: 21406714
MH  - Adult
MH  - *Diagnostic Imaging
MH  - Domestic Violence/*legislation & jurisprudence/*prevention & control
MH  - Female
MH  - Humans
MH  - Male
MH  - United States
MH  - Wounds and Injuries/*diagnosis
EDAT- 2010/11/05 06:00
MHDA- 2011/07/12 06:00
CRDT- 2010/11/05 06:00
PHST- 2010/11/05 06:00 [entrez]
PHST- 2010/11/05 06:00 [pubmed]
PHST- 2011/07/12 06:00 [medline]
AID - 82/2/133 [pii]
PST - ppublish
SO  - Radiol Technol. 2010 Nov-Dec;82(2):133-53.


PMID- 21046862
OWN - NLM
STAT- MEDLINE
DCOM- 20101223
LR  - 20101104
IS  - 0332-3102 (Print)
IS  - 0332-3102 (Linking)
VI  - 103
IP  - 8
DP  - 2010 Sep
TI  - Conflicting perspectives compromising discussions on cardiopulmonary
      resuscitation.
PG  - 233-5
AB  - Healthcare professionals, patients and their relatives are expected to discuss
      resuscitation together. This study aims to identify the differences in the
      knowledge base and understanding of these parties. Questionnaires examining
      knowledge and opinion on resuscitation matters were completed during interviews
      of randomly selected doctors, nurses and the general public. 70% doctors, 24%
      nurses and 0% of a public group correctly estimated survival to discharge
      following in-hospital resuscitation attempts. Deficiencies were identified in
      doctor and nurse knowledge of ethics governing resuscitation decisions. Public
      opinion often conflicts with ethical guidelines. Public understanding of the
      nature of cardiopulmonary arrests and resuscitation attempts; and of the
      implications of a 'Do Not Attempt Resuscitation (DNAR)' order is poor. Television
      medical dramas are the primary source of resuscitation knowledge. Deficiencies in
      healthcare professionals' knowledge of resuscitation ethics and outcomes may
      compromise resuscitation decisions. Educational initiatives to address
      deficiencies are necessary. Parties involved in discussion on resuscitation do
      not share the same knowledge base reducing the likelihood of meaningful
      discussion. Public misapprehensions surrounding resuscitation must be identified 
      and corrected during discussion.
FAU - Groarke, J
AU  - Groarke J
AD  - Department of Cardiology, St Luke's General Hospital, Kilkenny.
      johngroarke1@eircom.net
FAU - Gallagher, J
AU  - Gallagher J
FAU - McGovern, R
AU  - McGovern R
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Ir Med J
JT  - Irish medical journal
JID - 0430275
SB  - IM
MH  - *Cardiopulmonary Resuscitation/ethics
MH  - *Decision Making/ethics
MH  - Humans
MH  - Informed Consent
MH  - Physician-Patient Relations
EDAT- 2010/11/05 06:00
MHDA- 2010/12/25 06:00
CRDT- 2010/11/05 06:00
PHST- 2010/11/05 06:00 [entrez]
PHST- 2010/11/05 06:00 [pubmed]
PHST- 2010/12/25 06:00 [medline]
PST - ppublish
SO  - Ir Med J. 2010 Sep;103(8):233-5.


PMID- 21046533
OWN - NLM
STAT- MEDLINE
DCOM- 20101130
LR  - 20101103
IS  - 1439-4413 (Electronic)
IS  - 0012-0472 (Linking)
VI  - 135
IP  - 45
DP  - 2010 Nov
TI  - [Clinical ecomomics: a pleading for complementing the medical curriculum and
      specialty training].
PG  - 2257-62
LID - 10.1055/s-0030-1267509 [doi]
AB  - Clinical economics requires an understanding of clinical relationships just like 
      health economy requires an understanding of economic relationships. Hitherto we
      have ensured that economists can differentiate symptoms from diagnoses and
      diagnostics from screening at the interface between medicine and economy.
      However, we overlooked the fact that physicians should be able to understand the 
      principles of marginal benefit and medical ethics, as well as the differences
      among efficacy, effectiveness, and benefit, to be able to make sound decisions.
      To make up for this neglected demand, we present our definition of clinical
      economics, identify the potential conflicts between medical professionalism and
      commercialized medicine, describe the importance - but also the limits - of
      scientific evidence, explain the difference between 'prioritization' and strict
      rationing, and attempt to justify the fact that the necessary changes in the
      provision of healthcare will probably only be achieved if we instill this new way
      of thinking in medical students during their medical education. Complementing the
      medical curriculum with clinical economics would achieve this goal.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Porzsolt, F
AU  - Porzsolt F
AD  - Klinische Okonomik, Universitat Ulm, Ulm, Germany.
      franz.porzsolt@uniklinik-ulm.de
FAU - Weiss, M
AU  - Weiss M
FAU - Hege-Scheuing, G
AU  - Hege-Scheuing G
FAU - Fangerau, H
AU  - Fangerau H
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Klinische Okonomik--Ein Pladoyer fur die Erganzung der medizinischen Lehre und
      Spezialisierung.
DEP - 20101102
PL  - Germany
TA  - Dtsch Med Wochenschr
JT  - Deutsche medizinische Wochenschrift (1946)
JID - 0006723
SB  - IM
MH  - Commerce/economics/ethics
MH  - Cost-Benefit Analysis
MH  - Curriculum
MH  - Delivery of Health Care/*economics/ethics
MH  - *Education, Medical
MH  - Ethics, Medical
MH  - Evidence-Based Medicine/economics/ethics
MH  - Germany
MH  - Health Care Rationing/*economics/ethics
MH  - Health Care Reform/economics/ethics
MH  - Health Priorities/economics/ethics
MH  - Humans
MH  - National Health Programs/*economics/ethics
MH  - Specialization/*economics
MH  - Unnecessary Procedures/*economics/ethics
EDAT- 2010/11/04 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/11/04 06:00
PHST- 2010/11/04 06:00 [entrez]
PHST- 2010/11/04 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1055/s-0030-1267509 [doi]
PST - ppublish
SO  - Dtsch Med Wochenschr. 2010 Nov;135(45):2257-62. doi: 10.1055/s-0030-1267509. Epub
      2010 Nov 2.


PMID- 21046529
OWN - NLM
STAT- MEDLINE
DCOM- 20101130
LR  - 20220309
IS  - 1439-4413 (Electronic)
IS  - 0012-0472 (Linking)
VI  - 135
IP  - 45
DP  - 2010 Nov
TI  - [Treatment decisions in advanced cancer. An empirical-ethical study on
      physicians' criteria and the process of decision making].
PG  - 2230-4
LID - 10.1055/s-0030-1267505 [doi]
AB  - BACKGROUND AND RESEARCH QUESTION: Physicians' decisions regarding the indication 
      of medical treatment are central to the application or limitation of medical
      measures in advanced cancer. This qualitative study explores criteria and
      procedural aspects of treatment decisions with patients with cancer near the end 
      of life from the perspective of oncologists. RESEARCH PARTICIPANTS AND METHODS:
      In this qualitative interview study physicians working in the field of oncology
      were asked about their decisional criteria and procedural aspects of treatment
      decision making in cases of patients with advanced cancer. All interviews were
      audiotaped and transcribed. Qualitative data analysis was conducted in accordance
      with principles of "Grounded Theory". RESULTS: 17 research interviews had been
      analysed. Next to medical criteria the life-circumstances of the patients with
      respect to age and social situation as well as the perceived quality of the
      physician-patient-relationship were named as foundation for decisions about the
      application or limitation of medical treatment at the end of life. In addition
      situational factors such as time pressure or the available technical equipment
      were cited as relevant factors for the decisions. "Silent acquiescence" as the
      predominant decision making model which has been reconstructed on the basis of
      the narratives means that decisions about the limitation of medical treatment are
      not communicated explicitly within the physician-patient-relationship. This
      approach was justified by the interviewees in light of the long standing
      relationship between physicians and patients. CONCLUSIONS: The decisional
      criteria and procedural aspects of decision making in patients with advanced
      cancer which have been elicited in this qualitative study inform the current
      scientific and societal debate on ethically relevant aspects of end-of-life
      decision making in medicine.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Schildmann, J
AU  - Schildmann J
AD  - Institut fur Medizinische Ethik und Geschichte der Medizin, Ruhr-Universitat
      Bochum, Bochum, Germany. jan.schildmann@rub.de
FAU - Vollmann, J
AU  - Vollmann J
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Behandlungsentscheidungen bei Patienten mit fortgeschrittenen Tumorerkrankungen. 
      Eine empirisch-ethische Untersuchung zur arztlichen Indikationsstellung und
      Entscheidungsfindung.
DEP - 20101102
PL  - Germany
TA  - Dtsch Med Wochenschr
JT  - Deutsche medizinische Wochenschrift (1946)
JID - 0006723
SB  - IM
MH  - Adult
MH  - Advance Directives/ethics
MH  - Age Factors
MH  - Aged
MH  - *Attitude of Health Personnel
MH  - Clinical Competence
MH  - Communication
MH  - Data Collection
MH  - Disease Progression
MH  - *Ethics, Medical
MH  - Family Relations
MH  - Female
MH  - Germany
MH  - Humans
MH  - Interview, Psychological
MH  - Male
MH  - Medical Futility/*ethics
MH  - Medical Oncology/ethics
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Neoplasms/pathology/*therapy
MH  - Palliative Care/ethics
MH  - Physician-Patient Relations/ethics
MH  - Withholding Treatment/*ethics
EDAT- 2010/11/04 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/11/04 06:00
PHST- 2010/11/04 06:00 [entrez]
PHST- 2010/11/04 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1055/s-0030-1267505 [doi]
PST - ppublish
SO  - Dtsch Med Wochenschr. 2010 Nov;135(45):2230-4. doi: 10.1055/s-0030-1267505. Epub 
      2010 Nov 2.


PMID- 21046171
OWN - NLM
STAT- MEDLINE
DCOM- 20110509
LR  - 20211020
IS  - 1432-2129 (Electronic)
IS  - 0932-433X (Linking)
VI  - 24
IP  - 6
DP  - 2010 Dec
TI  - [Modafinil for the treatment of cancer-related fatigue : an intervention study].
PG  - 587-95
LID - 10.1007/s00482-010-0987-y [doi]
AB  - AIM: the authors conducted an open-label investigation examining the effects of
      modafinil in reducing fatigue in patients with cancer, undergoing cancer
      treatment, and receiving opioid therapy. METHODS: after approval by the local
      Ethics Committee and informed consent cancer patients who reported fatigue -
      defined as persistent tiredness interfering with usual functioning - were
      enrolled in the study. Once daily, patients received 100 mg open-label modafinil.
      The Fatigue Severity Scale (FSS), Epworth Sleepiness Scale (ESS), and a visual
      analogue scale (VAS, 0-10) were performed at baseline (t1), day 7 (t2), and day
      28 (t3). Further assessment comprised the d2 Test of Attention (d2), the Hamilton
      Depression Scale (HAMD), the Eastern Cooperative Oncology Group-Score (ECOG),
      side effects, and patients' satisfaction with modafinil treatment. RESULTS: of
      the 37 patients who were enrolled, 29 completed all assessments in the study.
      Modafinil had a significant effect on the FSS (t1 44.6+/-12.2, t2 39+/-12.4, t3
      35.3+/-13.8 (p=0.015), on the VAS (t1 6+/-3.1), t2 4.5+/-2.8, t3 3.7+/-2.8
      (p=0.005), and an insignificant effect on d2 parameters of neurophysiological
      functioning and ESS. No differences were seen for ECOG and patients'
      satisfaction. No severe adverse effects were detected. CONCLUSION: modafinil
      improved alertness and cognitive skills in patients receiving cancer pain
      treatment by enhancing vigilance and cognitive performance. Although confirmation
      of this preliminary result is needed, these findings suggest that modafinil may
      improve quality of life in this patient population. However, in Germany the use
      of modafinil for fatigue is off-label and careful assessment of fatigue is needed
      prior to treatment. Randomized controlled trials are needed to confirm this
      evidence.
FAU - Wirz, S
AU  - Wirz S
AD  - Abteilung fur Anasthesie, Interdisziplinare Intensivmedizin, Schmerztherapie,
      Palliativmedizin, CURA - katholisches Krankenhaus im Siebengebirge, Schulgenstr. 
      15, 53604 Bad Honnef, Deutschland. stefan.wirz@cura.org
FAU - Nadstawek, J
AU  - Nadstawek J
FAU - Kuhn, K U
AU  - Kuhn KU
FAU - Vater, S
AU  - Vater S
FAU - Junker, U
AU  - Junker U
FAU - Wartenberg, H C
AU  - Wartenberg HC
LA  - ger
PT  - Journal Article
TT  - Modafinil zur behandlung der tumorfatigue : eine interventionsstudie.
PL  - Germany
TA  - Schmerz
JT  - Schmerz (Berlin, Germany)
JID - 8906258
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Central Nervous System Stimulants)
RN  - R3UK8X3U3D (Modafinil)
SB  - IM
MH  - Activities of Daily Living/psychology
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Benzhydryl Compounds/*therapeutic use
MH  - Central Nervous System Stimulants/*therapeutic use
MH  - Depressive Disorder/drug therapy/psychology
MH  - Disability Evaluation
MH  - Double-Blind Method
MH  - Fatigue/*drug therapy/etiology/psychology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Modafinil
MH  - Neoplasms/*complications/*physiopathology/psychology
MH  - Neuropsychological Tests/statistics & numerical data
MH  - Pain Measurement/statistics & numerical data
MH  - Personality Assessment/statistics & numerical data
MH  - Psychometrics
MH  - Quality of Life/psychology
MH  - Risk Factors
MH  - Surveys and Questionnaires
EDAT- 2010/11/04 06:00
MHDA- 2011/05/10 06:00
CRDT- 2010/11/04 06:00
PHST- 2010/11/04 06:00 [entrez]
PHST- 2010/11/04 06:00 [pubmed]
PHST- 2011/05/10 06:00 [medline]
AID - 10.1007/s00482-010-0987-y [doi]
PST - ppublish
SO  - Schmerz. 2010 Dec;24(6):587-95. doi: 10.1007/s00482-010-0987-y.


PMID- 21045969
OWN - NLM
STAT- MEDLINE
DCOM- 20110217
LR  - 20211020
IS  - 1555-1377 (Electronic)
IS  - 1541-5457 (Linking)
VI  - 30
DP  - 2010
TI  - Orthopaedic surgeons and industry: the value proposition.
PG  - 35-8
AB  - Although the deferred and non-prosecution agreements entered into by five of the 
      leading orthopaedic implant companies have caused our profession to re-examine
      the surgeon-industry partnerships that have helped advance the field, the legal
      and ethical considerations in that relationship have not changed. Moving forward,
      the surgeon must recognize that a truly valuable exchange must be demonstrated
      and delivered in that relationship for compensation to be warranted. This paper
      summarizes the value proposition in the orthopaedic surgeon-industry partnership.
FAU - Callaghan, John J
AU  - Callaghan JJ
AD  - University of Iowa, Department of Orthopaedics and Rehabilitation, USA.
FAU - Liu, Steve S
AU  - Liu SS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Iowa Orthop J
JT  - The Iowa orthopaedic journal
JID - 8908272
SB  - IM
MH  - *Cooperative Behavior
MH  - Humans
MH  - Industry/ethics/legislation & jurisprudence/*trends
MH  - Orthopedics/ethics/legislation & jurisprudence/*trends
MH  - Physicians
MH  - Prostheses and Implants
MH  - United States
PMC - PMC2958268
EDAT- 2010/11/04 06:00
MHDA- 2011/02/18 06:00
CRDT- 2010/11/04 06:00
PHST- 2010/11/04 06:00 [entrez]
PHST- 2010/11/04 06:00 [pubmed]
PHST- 2011/02/18 06:00 [medline]
PST - ppublish
SO  - Iowa Orthop J. 2010;30:35-8.


PMID- 21045965
OWN - NLM
STAT- MEDLINE
DCOM- 20110217
LR  - 20220410
IS  - 1555-1377 (Electronic)
IS  - 1541-5457 (Linking)
VI  - 30
DP  - 2010
TI  - Ponseti clubfoot management: changing surgical trends in Nigeria.
PG  - 7-14
AB  - BACKGROUND: Congenital clubfoot treatment continues to be controversial
      particularly in a resource-constrained country. Comparative evaluation of
      clubfoot surgery with Ponseti methods has not been reported in West Africa.
      OBJECTIVES: To determine the effects of Ponseti techniques on clubfoot surgery
      frequency and patterns in Nigeria. METHODS: This was a prospective hospital-based
      intention-to-treat comparative study of clubfoot managed with Ponseti methods
      (PCG) and extensive soft tissue surgery (NPCG). The first step was a nonselective
      double-blind randomization of clubfoot patients into two groups using Excel
      software in a university teaching hospital setting. The control group was the
      NPCG patients. The patients' parents gave informed consent, and the medical
      research and ethics board approved the study protocol. Biodata was gathered,
      clubfoot patterns were analyzed, Dimeglio-Bensahel scoring was done, the number
      of casts applied was tallied, and patterns of surgeries were documented. The cost
      of care, recurrence and outcomes were evaluated. Kruskal-Wallis analysis and
      Mann-Whitney U technique were used, and an alpha error of < 0.05 at a CI of 95%
      were taken to be significant. RESULTS: We randomized 153 clubfeet (in 105
      clubfoot patients) into two treatment groups. Fifty NPCG patients (36.2%)
      underwent manipulation and extensive soft tissue surgery and 55 PCG patients
      (39.9%) were treated with Ponseti methods. Fifty-two patients of the Ponseti
      group had no form of surgery (94.5% vs. 32%, p<0.000). Extensive soft tissue
      surgery was indicated in 17 (34.0%) of the NPCG group, representing 8.9% of the
      total of 191 major orthopaedic surgeries within the study period. Thirty-five
      patients (70.0%) from the NPCG group required more than six casts compared to
      thirteen patients (23.6%) of the PCG (p<0.000). The mean care cost was high
      within the NPCG when compared to the Ponseti group (48% vs. 14.5%, p<0.000). The 
      Ponseti-treated group had fewer treatment complications (p<0.003), a lower
      recurrence rate (p<0.000) and satisfactory early outcome (p<0.000). CONCLUSION:
      Major clubfoot surgery was not commonly indicated among patients treated with the
      Ponseti method. The Ponseti clubfoot technique has reduced total care costs, cast
      utilization, clubfoot surgery frequency and has also changed the patterns of
      surgery performed for clubfoot in Nigeria.
FAU - Adegbehingbe, O O
AU  - Adegbehingbe OO
AD  - Obafemi Awolowo University, Faculty of Clinical Sciences, Department of
      Orthopaedic Surgery & Traumatology, Ile Ife Osun State, Nigeria.
      olayinkaadegbehingbe@yahoo.co.uk
FAU - Oginni, L M
AU  - Oginni LM
FAU - Ogundele, O J
AU  - Ogundele OJ
FAU - Ariyibi, A L
AU  - Ariyibi AL
FAU - Abiola, P O
AU  - Abiola PO
FAU - Ojo, O D
AU  - Ojo OD
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Iowa Orthop J
JT  - The Iowa orthopaedic journal
JID - 8908272
SB  - IM
MH  - Achilles Tendon/*surgery
MH  - Adolescent
MH  - Adult
MH  - Braces/economics/statistics & numerical data/*trends
MH  - Casts, Surgical/economics/statistics & numerical data/trends
MH  - Child
MH  - Child, Preschool
MH  - Clubfoot/epidemiology/*ethnology/*therapy
MH  - Double-Blind Method
MH  - Health Care Costs/trends
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Nigeria/epidemiology
MH  - Orthopedic Procedures/economics/statistics & numerical data/trends
MH  - Outcome Assessment, Health Care
MH  - Prospective Studies
MH  - Tenotomy/economics/statistics & numerical data/*trends
MH  - Young Adult
PMC - PMC2958264
EDAT- 2010/11/04 06:00
MHDA- 2011/02/18 06:00
CRDT- 2010/11/04 06:00
PHST- 2010/11/04 06:00 [entrez]
PHST- 2010/11/04 06:00 [pubmed]
PHST- 2011/02/18 06:00 [medline]
PST - ppublish
SO  - Iowa Orthop J. 2010;30:7-14.


PMID- 21045946
OWN - NLM
STAT- MEDLINE
DCOM- 20110217
LR  - 20211020
IS  - 1553-6467 (Electronic)
IS  - 0002-9459 (Linking)
VI  - 74
IP  - 6
DP  - 2010 Aug 10
TI  - Pharmacy students' attitudes toward death and end-of-life care.
PG  - 104
AB  - OBJECTIVES: To assess pharmacy students' attitudes toward death and end-of-life
      care. METHODS: Third-year pharmacy students enrolled in the Ethics in
      Christianity and Health Care course were administered a survey instrument prior
      to introduction of the topic of end-of-life care. Students' attitudes toward
      different professions' roles in end-of-life care and their comfort in discussing 
      end-of-life issues were assessed. The survey instrument was readministered to the
      same students at the end of their fourth year. RESULTS: On most survey items,
      female students responded more favorably toward death and end-of-life care than
      male students. One exception was the perceived emotional ability to be in the
      room of a dying patient or loved one. Post-experiential survey responses were
      generally more favorable toward death and end-of-life care than were
      pre-discussion responses. CONCLUSIONS: In general, when surveyed concerning death
      and end-of-life care, female students responded more favorably than male
      students, and responses at the end of the fourth year were more favorable than at
      the beginning of the course.
FAU - Beall, Jennifer W
AU  - Beall JW
AD  - McWhorter School of Pharmacy, Samford University, 800Lakeshore Drive, Birmingham,
      AL 35229, USA. jwbeall@samford.edu
FAU - Broeseker, Amy E
AU  - Broeseker AE
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Pharm Educ
JT  - American journal of pharmaceutical education
JID - 0372650
SB  - IM
MH  - Adult
MH  - Attitude of Health Personnel
MH  - *Attitude to Death
MH  - Data Collection
MH  - Education, Pharmacy/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Sex Factors
MH  - Students, Pharmacy/*psychology
MH  - Terminal Care/*psychology
MH  - Young Adult
PMC - PMC2933013
OTO - NOTNLM
OT  - attitudes
OT  - death
OT  - end-of-life care
OT  - pharmacy students
EDAT- 2010/11/04 06:00
MHDA- 2011/02/18 06:00
CRDT- 2010/11/04 06:00
PHST- 2009/09/30 00:00 [received]
PHST- 2010/03/06 00:00 [accepted]
PHST- 2010/11/04 06:00 [entrez]
PHST- 2010/11/04 06:00 [pubmed]
PHST- 2011/02/18 06:00 [medline]
AID - 10.5688/aj7406104 [doi]
PST - ppublish
SO  - Am J Pharm Educ. 2010 Aug 10;74(6):104. doi: 10.5688/aj7406104.


PMID- 21045782
OWN - NLM
STAT- MEDLINE
DCOM- 20110217
LR  - 20101103
IS  - 1827-1898 (Electronic)
IS  - 0031-0808 (Linking)
VI  - 52
IP  - 3
DP  - 2010 Sep
TI  - Psychosomatic approach is the new medicine tailored for patient personality with 
      a focus on ethics, economy, and quality.
PG  - 249-64
AB  - Over the last 40 years the proliferation of the biopsychosocial (BPS) model
      across clinical and theoretical research has shown that psychosocial factors can 
      be shown to be causes, co-factors, or sequelae of many illnesses. Scientific
      presuppositions about the BPS model have been grounded firmly in
      psychobiological, psycho-behavioural, sociobiological, and socio-behavioural
      processes. According to the allostatic load model, stressful factors can be
      psychological ones or any other factor that is able to modify the stress-response
      system; these might include genetic factors or life experiences. Personality
      profiles, in particular, seem to be predictive of responses to different
      stressors. Stress responses preceding or following illness are clearly related,
      from a psychobiological point of view, to different personality traits, which
      themselves correlate to specific defence mechanisms. Neural processes underlying 
      these mechanisms interact with the biological substrate of somatic illnesses.
      Recent advances in brain imaging with regard to neurobiological and behavioural
      interactions of empathy and alexithymia support the crucial role of the (psycho) 
      therapeutic relationship across the whole of medical practice. Psychotherapies
      operate as biological factors on mind, brain, and body; indeed it is necessary to
      reconsider the doctor-patient relationship as a psychotherapeutic process. The
      basic methodological triad of observation (outer viewing), introspection (inner
      viewing), and dialogue (inter viewing) becomes essential in medical practice and 
      in scientific research. Psychoanalytic processes such as transference,
      resistance, the therapeutic alliance, and attachment have been reconsidered from 
      a neuroscientific perspective and reconceived as moments of meeting of the
      procedural memory and are therefore considered relevant to the relationship with 
      patients in primary care. Indeed, they are useful to an ethical approach to
      understanding the meaning of illness, and they also influence the results of
      treatment projects. Because all these aspects impact upon illness duration and
      quality of life, affecting both the individual concerned and his or her family,
      the economic consequences of this psychosomatic approach are important in both
      general and specialist medicine. Medicine is becoming, and will become even more 
      in the future, an integrated science; human illness and the maintenance of good
      health may be better understood if all medical disciplines are considered as a
      whole. The domain of psychosomatic medicine has now extended to coincide with
      that of medical practice. There is increasing evidence, not only in psychiatry,
      but in all medical fields, that care of the mental well-being of a person is
      essential for effective care of the body. Not only mens sana in corpore sano, but
      also corpus sanus in mente sana.
FAU - Fassino, S
AU  - Fassino S
AD  - Section of Psychiatry, Eating Disorders Centre Department of Neuroscience,
      University of Turin, Turin, Italy. secondo.fassino@unito.it
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - Panminerva Med
JT  - Panminerva medica
JID - 0421110
SB  - IM
MH  - Health Care Costs
MH  - Humans
MH  - Models, Psychological
MH  - *Personality
MH  - Physician-Patient Relations
MH  - *Psychosomatic Medicine/economics/education/ethics
MH  - Stress, Psychological/psychology
EDAT- 2010/11/04 06:00
MHDA- 2011/02/18 06:00
CRDT- 2010/11/04 06:00
PHST- 2010/11/04 06:00 [entrez]
PHST- 2010/11/04 06:00 [pubmed]
PHST- 2011/02/18 06:00 [medline]
AID - R41102536 [pii]
PST - ppublish
SO  - Panminerva Med. 2010 Sep;52(3):249-64.


PMID- 21045742
OWN - NLM
STAT- MEDLINE
DCOM- 20110201
LR  - 20151119
IS  - 1529-8809 (Electronic)
IS  - 0022-5282 (Linking)
VI  - 69
IP  - 6
DP  - 2010 Dec
TI  - The impact of country and culture on end-of-life care for injured patients:
      results from an international survey.
PG  - 1323-33; discussion 1333-4
LID - 10.1097/TA.0b013e3181f66878 [doi]
AB  - BACKGROUND: Up to 20% of all trauma patients admitted to an intensive care unit
      die from their injuries. End-of-life decision making is a variable process that
      involves prognosis, predicted functional outcomes, personal beliefs,
      institutional resources, societal norms, and clinician experience. The goal of
      this study was to better understand end-of-life processes after major injury by
      comparing clinician viewpoints from various countries and cultures. METHODS: A
      clinician-based, 38-question international survey was used to characterize the
      impacts of medical, religious, social, and system factors on end-of-life care
      after trauma. RESULTS: A total of 419 clinicians from the United States (49%),
      Canada (19%), South Africa (11%), Europe (9%), Asia (8%), and Australasia (4%)
      completed the survey. In America, the admitting surgeon guided most end-of-life
      decisions (51%), when compared with all other countries (0-27%). The practice
      structure of American respondents also varied from other regions. Formal medical 
      futility laws are rarely available (14-38%). Ethical consultation services are
      often accessible (29-98%), but rarely used (0-29%), and typically unhelpful
      (<30%). End-of-life decision making for patients with traumatic brain injuries
      varied extensively across regions with regard to the impact of patient age,
      Glasgow Coma Scale score, and clinician philosophy. Similar differences were
      observed for spinal cord injuries (age and functional level). The availability
      and use of "donation after cardiac death" also varied substantially between
      countries. CONCLUSIONS: In this unique study, geographic differences in religion,
      practice composition, decision-maker viewpoint, and institutional resources
      resulted in significant variation in end-of-life care after injury. These
      disparities reflect competing concepts (patient autonomy, distributive justice,
      and religion).
FAU - Ball, Chad G
AU  - Ball CG
AD  - Department of Surgery, Emory University, Grady Memorial Hospital, Atlanta,
      Georgia, USA.
FAU - Navsaria, Pradeep
AU  - Navsaria P
FAU - Kirkpatrick, Andrew W
AU  - Kirkpatrick AW
FAU - Vercler, Christian
AU  - Vercler C
FAU - Dixon, Elijah
AU  - Dixon E
FAU - Zink, John
AU  - Zink J
FAU - Laupland, Kevin B
AU  - Laupland KB
FAU - Lowe, Michael
AU  - Lowe M
FAU - Salomone, Jeffrey P
AU  - Salomone JP
FAU - Dente, Christopher J
AU  - Dente CJ
FAU - Wyrzykowski, Amy D
AU  - Wyrzykowski AD
FAU - Hameed, S Morad
AU  - Hameed SM
FAU - Widder, Sandy
AU  - Widder S
FAU - Inaba, Kenji
AU  - Inaba K
FAU - Ball, Jill E
AU  - Ball JE
FAU - Rozycki, Grace S
AU  - Rozycki GS
FAU - Montgomery, Sean P
AU  - Montgomery SP
FAU - Hayward, Thomas
AU  - Hayward T
FAU - Feliciano, David V
AU  - Feliciano DV
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Trauma
JT  - The Journal of trauma
JID - 0376373
SB  - IM
MH  - Asia
MH  - Attitude of Health Personnel
MH  - Australasia
MH  - Canada
MH  - *Culture
MH  - *Decision Making
MH  - Europe
MH  - Health Resources
MH  - Humans
MH  - *Intensive Care Units
MH  - Medical Futility/legislation & jurisprudence
MH  - Physician-Patient Relations
MH  - Religion
MH  - South Africa
MH  - Surveys and Questionnaires
MH  - *Terminal Care
MH  - Tissue and Organ Procurement
MH  - United States
EDAT- 2010/11/04 06:00
MHDA- 2011/02/02 06:00
CRDT- 2010/11/04 06:00
PHST- 2010/11/04 06:00 [entrez]
PHST- 2010/11/04 06:00 [pubmed]
PHST- 2011/02/02 06:00 [medline]
AID - 10.1097/TA.0b013e3181f66878 [doi]
PST - ppublish
SO  - J Trauma. 2010 Dec;69(6):1323-33; discussion 1333-4. doi:
      10.1097/TA.0b013e3181f66878.


PMID- 21045708
OWN - NLM
STAT- MEDLINE
DCOM- 20111019
LR  - 20220210
IS  - 1530-0366 (Electronic)
IS  - 1098-3600 (Linking)
VI  - 12
IP  - 12
DP  - 2010 Dec
TI  - Parental preferences for CDKN2A/p16 testing of minors.
PG  - 823-38
LID - 10.1097/GIM.0b013e3181f87278 [doi]
AB  - PURPOSE: Genetic testing of minors is controversial, as ethical considerations
      depend on multiple aspects of the particular disease and familial context. For
      melanoma, there is a well-established and avoidable environmental influence and a
      documented benefit of early detection. METHODS: We surveyed 61 CDKN2A/p16
      mutation-tested adults from two kindreds about their attitudes toward genetic
      testing of minors immediately posttesting and 2 years later. RESULTS: Overall,
      86.9% expressed support of melanoma genetic testing of minors, with the
      importance of risk awareness (77.4%) and the likelihood of improved prevention
      and screening behaviors (69.8%) as the most frequently cited potential benefits. 
      Among mutation carriers, 82.6% wanted genetic testing for their own children.
      These preferences remained stable over a 2-year period. Most respondents (62.3%) 
      favored complete involvement of their children in genetic counseling and test
      reporting; 19.7% suggested that children be tested but not informed of the
      results. Concerns about inducing psychological distress or compromising
      children's decision autonomy were infrequently cited. Testing preferences did not
      vary by respondent age, gender, or melanoma history. CONCLUSION: Respondents
      strongly supported melanoma genetic testing of minors, with most citing improved 
      health behavior as a likely outcome. We discuss options for melanoma genetic
      counseling and testing of minors.
FAU - Taber, Jennifer M
AU  - Taber JM
AD  - Department of Psychology, University of Utah, Salt Lake City, Utah 84112-0251,
      USA.
FAU - Aspinwall, Lisa G
AU  - Aspinwall LG
FAU - Kohlmann, Wendy
AU  - Kohlmann W
FAU - Dow, Reed
AU  - Dow R
FAU - Leachman, Sancy A
AU  - Leachman SA
LA  - eng
GR  - 1KL2RR025763-01/RR/NCRR NIH HHS/United States
GR  - 5P30CA420-14/CA/NCI NIH HHS/United States
GR  - N01-PC-35141/PC/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genet Med
JT  - Genetics in medicine : official journal of the American College of Medical
      Genetics
JID - 9815831
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p16)
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Aged
MH  - Aged, 80 and over
MH  - Cyclin-Dependent Kinase Inhibitor p16/*genetics
MH  - Female
MH  - Follow-Up Studies
MH  - Genetic Counseling
MH  - Genetic Predisposition to Disease
MH  - Genetic Testing/*statistics & numerical data
MH  - Heterozygote
MH  - Humans
MH  - Male
MH  - Melanoma/diagnosis/epidemiology/genetics
MH  - Middle Aged
MH  - *Minors
MH  - *Parental Consent/statistics & numerical data
MH  - Patient Preference/*statistics & numerical data
MH  - Skin Neoplasms/diagnosis/epidemiology/genetics
MH  - Young Adult
EDAT- 2010/11/04 06:00
MHDA- 2011/10/20 06:00
CRDT- 2010/11/04 06:00
PHST- 2010/11/04 06:00 [entrez]
PHST- 2010/11/04 06:00 [pubmed]
PHST- 2011/10/20 06:00 [medline]
AID - 10.1097/GIM.0b013e3181f87278 [doi]
AID - S1098-3600(21)01988-2 [pii]
PST - ppublish
SO  - Genet Med. 2010 Dec;12(12):823-38. doi: 10.1097/GIM.0b013e3181f87278.


PMID- 21045577
OWN - NLM
STAT- MEDLINE
DCOM- 20110217
LR  - 20101103
IS  - 1559-7776 (Electronic)
IS  - 1559-7768 (Linking)
VI  - 21
IP  - 4
DP  - 2010 Oct-Dec
TI  - Ethics of nursing shift report.
PG  - 380-4
LID - 10.1097/NCI.0b013e3181ef8648 [doi]
FAU - Rushton, Cynda Hylton
AU  - Rushton CH
AD  - School of Nursing Johns Hopkins University, 525 N Wolfe St, Box 420, Baltimore,
      MD 21287, USA. crushton@son.jhmi.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - AACN Adv Crit Care
JT  - AACN advanced critical care
JID - 101269322
MH  - *Communication
MH  - Critical Illness/*nursing
MH  - *Ethics, Nursing
MH  - Humans
MH  - Intensive Care Units/*ethics
MH  - *Nursing Records
MH  - Patient Care Team/ethics
MH  - Privacy
MH  - Time Factors
EDAT- 2010/11/04 06:00
MHDA- 2011/02/18 06:00
CRDT- 2010/11/04 06:00
PHST- 2010/11/04 06:00 [entrez]
PHST- 2010/11/04 06:00 [pubmed]
PHST- 2011/02/18 06:00 [medline]
AID - 10.1097/NCI.0b013e3181ef8648 [doi]
AID - 01256961-201010000-00010 [pii]
PST - ppublish
SO  - AACN Adv Crit Care. 2010 Oct-Dec;21(4):380-4. doi: 10.1097/NCI.0b013e3181ef8648.


PMID- 21045351
OWN - NLM
STAT- MEDLINE
DCOM- 20110531
LR  - 20220316
IS  - 1972-2680 (Electronic)
IS  - 1972-2680 (Linking)
VI  - 4
IP  - 10
DP  - 2010 Oct 28
TI  - Modeling the transmission dynamics of HIV/AIDS epidemics: an introduction and a
      review.
PG  - 597-608
AB  - INTRODUCTION: One of the greatest causes of morbidity and mortality in the
      Sub-Saharan Africa, particularly among young adults is HIV/AIDS. Many
      Mathematical models have been suggested for describing the epidemiology as well
      as the epidemiological consequences of the epidemic. It is very necessary to
      review some of these models so as to aid researchers in applying some of them to 
      the situations in their countries. METHODOLOGY: In this study, we review many of 
      the models proposed by various author and how some of them could be modified to
      suit the situations in other countries. We also discuss the limitations and the
      place of such models in the fight against HIV epidemic. RESULTS: We reviewed
      models across different scenarios and ensured that the models are reviewed in
      such a manner that would lead to a clearer understanding of the premises and
      assumptions on which the models were based. CONCLUSION: Mathematical models have 
      been very useful in HIV research; particularly that empirical studies with People
      Living With HIV/AIDS (PLWHA) is generating a lot of ethical issues.
FAU - Akpa, Onoja Matthew
AU  - Akpa OM
AD  - Deparment of Mathematical Sciences, Redeemer's University, Redemption City, Ogun 
      State, Nigeria. onojamatthew@yahoo.co.uk
FAU - Oyejola, Benjamin Agboola
AU  - Oyejola BA
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20101028
PL  - Italy
TA  - J Infect Dev Ctries
JT  - Journal of infection in developing countries
JID - 101305410
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/*epidemiology/*transmission
MH  - Africa South of the Sahara/epidemiology
MH  - Humans
MH  - Incidence
MH  - *Models, Statistical
EDAT- 2010/11/04 06:00
MHDA- 2011/06/01 06:00
CRDT- 2010/11/04 06:00
PHST- 2009/09/29 00:00 [received]
PHST- 2010/06/09 00:00 [accepted]
PHST- 2010/11/04 06:00 [entrez]
PHST- 2010/11/04 06:00 [pubmed]
PHST- 2011/06/01 06:00 [medline]
AID - 10.3855/jidc.542 [doi]
PST - epublish
SO  - J Infect Dev Ctries. 2010 Oct 28;4(10):597-608. doi: 10.3855/jidc.542.


PMID- 21045227
OWN - NLM
STAT- MEDLINE
DCOM- 20101208
LR  - 20220316
IS  - 1930-7837 (Electronic)
IS  - 0022-0337 (Linking)
VI  - 74
IP  - 11
DP  - 2010 Nov
TI  - The "hot seat" experience: a multifaceted approach to the teaching of ethics in a
      dental curriculum.
PG  - 1220-9
AB  - The subject of ethics and the teaching of skills associated with ethical
      reasoning in a predoctoral dental curriculum are as important as clinical skills 
      development, but there is no single approach to teaching ethics in dentistry.
      This article aims to describe the didactic approach used to teach dental ethics
      and ethical reasoning in the first year of the D.M.D. curriculum at the
      University of British Columbia. This descriptive article discusses three main
      pedagogies employed to teach ethics: the "hot seat" experience via a role-play
      with a trained actor (standardized patient, SP); small-group presentations of a
      case workup deconstructing an ethical dilemma; and student reflections from the
      SP encounters. The approach to dental ethics presented here does not profess to
      make an otherwise unethical person ethical, but it can give all students the
      tools to recognize when a dilemma exists, use a process to reason ethically, and 
      ultimately make a good decision. The "hot seat" and the case workup approaches
      have had a positive impact upon students as illustrated through their
      reflections; however, further study is needed to better understand the
      implications of ethical issues in both academic and professional settings.
FAU - Brondani, Mario A
AU  - Brondani MA
AD  - Department of Oral Health Sciences, Faculty of Dentistry, University of British
      Columbia, 2199 Wesbrook Mall, Vancouver, British Columbia V6T 1Z3, Canada.
      brondani@interchange.ubc.ca
FAU - Rossoff, Lawrence P
AU  - Rossoff LP
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Dent Educ
JT  - Journal of dental education
JID - 8000150
SB  - IM
MH  - Attitude of Health Personnel
MH  - British Columbia
MH  - Clinical Competence
MH  - Confidentiality
MH  - Conflict, Psychological
MH  - *Curriculum
MH  - Decision Making
MH  - *Education, Dental
MH  - Ethics, Dental/*education
MH  - Fraud
MH  - Humans
MH  - Infection Control, Dental
MH  - Informed Consent
MH  - Interprofessional Relations
MH  - Morals
MH  - Patient Simulation
MH  - Personal Autonomy
MH  - Police
MH  - Problem-Based Learning
MH  - Professional Impairment
MH  - Professional-Patient Relations
MH  - Referral and Consultation
MH  - Role Playing
MH  - Social Behavior
MH  - Social Responsibility
MH  - Students, Dental/psychology
MH  - Teaching/*methods
EDAT- 2010/11/04 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/11/04 06:00
PHST- 2010/11/04 06:00 [entrez]
PHST- 2010/11/04 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 74/11/1220 [pii]
PST - ppublish
SO  - J Dent Educ. 2010 Nov;74(11):1220-9.


PMID- 21045226
OWN - NLM
STAT- MEDLINE
DCOM- 20101208
LR  - 20101103
IS  - 1930-7837 (Electronic)
IS  - 0022-0337 (Linking)
VI  - 74
IP  - 11
DP  - 2010 Nov
TI  - Allied dental and dental educators' perceptions of and reporting practices on
      academic dishonesty.
PG  - 1214-9
AB  - Highly publicized reports and current research on cheating in dental schools and 
      dental hygiene programs have created a resurgence of proactive measures in the
      deterrence of academic dishonesty. A majority of administrators and faculty
      members are of the opinion that cheating does occur at their schools and may have
      been personally involved with incidents of cheating through observation or
      student reporting. With the information age and the diverse makeup of today's
      student body, there may be differences in what is considered academic dishonesty 
      between students and educators. The purpose of this study was to elicit
      perceptions on those differences, ascertain the number of cheating incidents that
      educators personally witnessed or about which they received information, and
      determine how they resolved those incidents. Another aim of this study was to
      determine if having an honor code, adequate ethics training, honor pledges,
      dialogue in the classroom, and formal due process policy were related to the
      number of cheating incidents. Surveys were distributed at the educational program
      of the American Dental Education Association (ADEA) Section on Dental Hygiene
      Education at the 2009 ADEA Annual Session & Exhibition. Results show the majority
      of these educators had had experience with cheating occurrences and believe that 
      there are disparities between students and educators and among cultural groups in
      defining academic dishonesty. No differences or patterns emerged between academic
      integrity characteristics and occurrences or reports of cheating.
FAU - Muhney, Kelly A
AU  - Muhney KA
AD  - Department of Dental Hygiene, Baylor College of Dentistry, 3302 Gaston Ave.,
      Dallas, TX 75246, USA. kmuhney@bcd.tamhsc.edu
FAU - Campbell, Patricia R
AU  - Campbell PR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Dent Educ
JT  - Journal of dental education
JID - 8000150
SB  - IM
MH  - Administrative Personnel/ethics/*psychology
MH  - *Attitude of Health Personnel
MH  - Codes of Ethics
MH  - Culture
MH  - *Deception
MH  - Dental Hygienists/*education/ethics
MH  - *Education, Dental
MH  - Ethics, Dental/education
MH  - *Faculty, Dental
MH  - Humans
MH  - Intergenerational Relations
MH  - Interpersonal Relations
MH  - Morals
MH  - Students
MH  - Students, Dental
EDAT- 2010/11/04 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/11/04 06:00
PHST- 2010/11/04 06:00 [entrez]
PHST- 2010/11/04 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 74/11/1214 [pii]
PST - ppublish
SO  - J Dent Educ. 2010 Nov;74(11):1214-9.


PMID- 21045184
OWN - NLM
STAT- MEDLINE
DCOM- 20110201
LR  - 20170916
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 258
IP  - 1
DP  - 2011 Jan
TI  - Use of tomosynthesis for erosion evaluation in rheumatoid arthritic hands and
      wrists.
PG  - 199-205
LID - 10.1148/radiol.10100791 [doi]
AB  - PURPOSE: To compare tomosynthesis with radiography for the detection of hand and 
      wrist bone erosions in patients with rheumatoid arthritis (RA), using
      multidetector computed tomography (CT) as the reference method. MATERIALS AND
      METHODS: The study was approved by the local ethics committee, and written
      consent was obtained from all patients. From December 2008 to April 2009, 30
      consecutive patients with RA were included in this prospective study. They
      underwent radiography, tomosynthesis, and CT of the most symptomatic hand and
      wrist on the same day. Two radiologists and one rheumatologist independently read
      images from the three imaging modalities. RESULTS: A total of 232 erosions were
      detected with CT, while 199 and 140 erosions, respectively, were detected with
      tomosynthesis and radiography. More erosions were revealed with CT than with
      tomosynthesis and radiography (P < .0001); significantly more erosions were shown
      with tomosynthesis than with radiography (P < .0001). With CT as the reference
      method for bone erosions, the overall sensitivity, specificity, and accuracy of
      tomosynthesis were, respectively, 77.6%, 89.9%, and 83.1%. The corresponding
      values for radiography were 53.9%, 92%, and 70.9%. The sensitivity of each reader
      increased by roughly 20% with use of tomosynthesis. CONCLUSION: The depiction of 
      bone erosions of the hands and wrists is significantly greater with tomosynthesis
      than with radiography.
CI  - (c) RSNA, 2010
FAU - Canella, Clarissa
AU  - Canella C
AD  - Department of Musculoskeletal Radiology, Centre de Consultations et d'Imagerie de
      l'Appareil Locomoteur, Centre Hospitalier Regional Universitaire de Lille, Rue du
      Professeur Emilie Laine, Lille 59000, France. clacanella@yahoo.com.br
FAU - Philippe, Peggy
AU  - Philippe P
FAU - Pansini, Vittorio
AU  - Pansini V
FAU - Salleron, Julia
AU  - Salleron J
FAU - Flipo, Rene-Marc
AU  - Flipo RM
FAU - Cotten, Anne
AU  - Cotten A
LA  - eng
PT  - Journal Article
DEP - 20101102
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
CIN - Radiologe. 2011 Nov;51(11):919-20. PMID: 22015983
MH  - Adult
MH  - Aged
MH  - Arthritis, Rheumatoid/*diagnostic imaging/pathology
MH  - Female
MH  - Hand/*diagnostic imaging/pathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Radiographic Image Enhancement/methods
MH  - Radiographic Image Interpretation, Computer-Assisted/*methods
MH  - Sensitivity and Specificity
MH  - Statistics, Nonparametric
MH  - Tomography, X-Ray Computed
MH  - Wrist/*diagnostic imaging/pathology
MH  - Wrist Joint/*diagnostic imaging/pathology
EDAT- 2010/11/04 06:00
MHDA- 2011/02/02 06:00
CRDT- 2010/11/04 06:00
PHST- 2010/11/04 06:00 [entrez]
PHST- 2010/11/04 06:00 [pubmed]
PHST- 2011/02/02 06:00 [medline]
AID - radiol.10100791 [pii]
AID - 10.1148/radiol.10100791 [doi]
PST - ppublish
SO  - Radiology. 2011 Jan;258(1):199-205. doi: 10.1148/radiol.10100791. Epub 2010 Nov
      2.


PMID- 21045177
OWN - NLM
STAT- MEDLINE
DCOM- 20110110
LR  - 20220408
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 257
IP  - 3
DP  - 2010 Dec
TI  - MR imaging helps predict time from symptom onset in patients with acute stroke:
      implications for patients with unknown onset time.
PG  - 782-92
LID - 10.1148/radiol.10100461 [doi]
AB  - PURPOSE: To assess the value of magnetic resonance (MR) imaging parameters as
      surrogate markers of stroke duration. MATERIALS AND METHODS: The study was
      approved by the Ethics Committee of Ile de France III and was found to conform to
      generally accepted scientific principles and ethical standards. The authors
      studied 130 patients with acute stroke of known onset time who underwent 1.5-T MR
      imaging within 12 hours of the onset of stroke symptoms. Fluid-attenuated
      inversion recovery (FLAIR), diffusion-weighted (DW) imaging, and apparent
      diffusion coefficient (ADC) ratios were computed by using three-dimensional
      regions of interest to outline signal intensity changes on DW images and then
      projecting them onto the contralateral hemisphere. Imaging ratios in 63 patients 
      who underwent imaging 0-3 hours after symptom onset were compared with those in
      67 patients who underwent imaging more than 3 hours after onset by using the
      Student t test and receiver operating characteristic curves. The accuracy
      (sensitivity, specificity, and 95% confidence intervals [CIs]) of lesion
      visibility on FLAIR images in the prediction of a stroke onset time of less than 
      3 hours was assessed by two independent observers. RESULTS: Differences in
      imaging ratios between patients imaged 0-3 hours after symptom onset and those
      imaged more than 3 hours after onset were statistically significant (P < .001).
      The FLAIR ratio showed a positive correlation with the time from symptom onset
      (Pearson correlation coefficient, 0.63). Receiver operating characteristic curves
      indicated that the FLAIR ratio could reliably identify patients imaged 0-3 hours 
      after symptom onset, reaching 90% sensitivity (95% CI: 83%, 98%) and 93%
      specificity (95% CI: 86%, 99%) when using a 7% cutoff. Stroke imaged within 3
      hours could also be identified by means of visual inspection of FLAIR and DW MR
      images, with 94% sensitivity (95% CI: 88%, 100%) and 97% specificity (95% CI:
      93%, 101%). CONCLUSION: Signal intensity changes on 1.5-T FLAIR MR images can be 
      used as a surrogate marker of stroke age, either qualitatively or quantitatively.
      This suggests that MR imaging might be used as a "clock" for determining stroke
      age in patients with an unknown onset time, potentially increasing the number of 
      patients who are eligible for thrombolysis.
CI  - (c) RSNA, 2010.
FAU - Petkova, Mina
AU  - Petkova M
AD  - Department of Radiology, Universite Paris Descartes, INSERM U894, Centre
      Hospitalier Sainte-Anne, 1 rue Cabanis, 75014 Paris, France.
FAU - Rodrigo, Sebastian
AU  - Rodrigo S
FAU - Lamy, Catherine
AU  - Lamy C
FAU - Oppenheim, Georges
AU  - Oppenheim G
FAU - Touze, Emmanuel
AU  - Touze E
FAU - Mas, Jean-Louis
AU  - Mas JL
FAU - Meder, Jean-Francois
AU  - Meder JF
FAU - Oppenheim, Catherine
AU  - Oppenheim C
LA  - eng
PT  - Journal Article
DEP - 20101102
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Chi-Square Distribution
MH  - Confidence Intervals
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - ROC Curve
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - Stroke/*diagnosis
EDAT- 2010/11/04 06:00
MHDA- 2011/01/11 06:00
CRDT- 2010/11/04 06:00
PHST- 2010/11/04 06:00 [entrez]
PHST- 2010/11/04 06:00 [pubmed]
PHST- 2011/01/11 06:00 [medline]
AID - radiol.10100461 [pii]
AID - 10.1148/radiol.10100461 [doi]
PST - ppublish
SO  - Radiology. 2010 Dec;257(3):782-92. doi: 10.1148/radiol.10100461. Epub 2010 Nov 2.


PMID- 21044618
OWN - NLM
STAT- MEDLINE
DCOM- 20110502
LR  - 20141120
IS  - 1879-0712 (Electronic)
IS  - 0014-2999 (Linking)
VI  - 650
IP  - 2-3
DP  - 2011 Jan 15
TI  - Thromboxane A2 induces contraction of human prostate smooth muscle by Rho kinase-
      and calmodulin-dependent mechanisms.
PG  - 650-5
LID - 10.1016/j.ejphar.2010.10.052 [doi]
AB  - Thromboxane A(2) (TXA(2)) induces contraction in different smooth muscle types
      via its receptor (TXA(2) receptor). However, any motoric role of TXA(2) in
      prostate smooth muscle tone has not been studied to date. Here, we investigated
      whether TXA(2) induces contraction of human prostate tissue. After ethical
      approval, prostate tissue was obtained from 47 patients undergoing radical
      prostatectomy. Effects of the TXA(2) analogue U46619
      ((5Z)-7-[(1R,4S,5S,6R)-6-[(1E,3S)-3-hydroxy-1-octenyl]-2-oxabicyclo[2.2.1]hept-5-
      yl]-5-heptonic acid) in isolated human prostate strips were studied in organ bath
      experiments with or without the Rho kinase inhibitor, Y27632
      (trans-4-[(1R)-1-aminoethyl]-N-4-pyridinylcyclohexanecarboxamide
      dihydrochloride), or the calmodulin antagonist W7
      (N-(6-aminohexyl)-5-chloro-1-naphtalenesulfonamide hydrochloride). Expression of 
      TXA(2) synthase and TXA(2) receptors were examined by Western blot analysis and
      immunohistochemistry. Endogenous TXA(2) was quantified by enzyme immunoassay.
      U46619 induced concentration-dependent contractions of human prostate strips,
      with a maximum contraction at 3 muM. U46619-induced prostate contraction was
      significantly inhibited by Y27632 (30 muM) and by W7 (100 muM). TXA(2) synthase
      and TXA(2) receptors were detected by Western blot analysis. Immunohistochemical 
      stainings showed that expression of TXA(2) synthase in prostate tissue was
      located to glandular cells, while prostate TXA(2) receptors were located to
      smooth muscle and glandular cells. The stable TXA(2) metabolite TXB(2) was
      detected by enzyme immunoassay in the prostate. TXA(2) induces contraction of
      isolated human prostate tissue by TXA(2) receptor activation. Prostate smooth
      muscle TXA(2) receptors are coupled to Rho kinase and Ca(2+)-dependent
      mechanisms. The distribution of TXA(2) synthase and TXA(2) receptors in the human
      prostate suggests TXA(2)-mediated paracrine epithelial-stromal interactions.
CI  - Copyright (c) 2010 Elsevier B.V. All rights reserved.
FAU - Strittmatter, Frank
AU  - Strittmatter F
AD  - Department of Urology, University of Munich, Munich, Germany.
FAU - Gratzke, Christian
AU  - Gratzke C
FAU - Weinhold, Philipp
AU  - Weinhold P
FAU - Steib, Christian J
AU  - Steib CJ
FAU - Hartmann, Anna C
AU  - Hartmann AC
FAU - Schlenker, Boris
AU  - Schlenker B
FAU - Andersson, Karl-Erik
AU  - Andersson KE
FAU - Hedlund, Petter
AU  - Hedlund P
FAU - Stief, Christian G
AU  - Stief CG
FAU - Hennenberg, Martin
AU  - Hennenberg M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101031
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Amides)
RN  - 0 (Calmodulin)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Pyridines)
RN  - 0 (Receptors, Thromboxane A2, Prostaglandin H2)
RN  - 0 (Sulfonamides)
RN  - 0 (Vasoconstrictor Agents)
RN  - 138381-45-0 (Y 27632)
RN  - 57576-52-0 (Thromboxane A2)
RN  - 65595-90-6 (W 7)
RN  - 76898-47-0 (15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid)
RN  - EC 2.7.11.1 (rho-Associated Kinases)
RN  - EC 5.3.99.5 (Thromboxane-A Synthase)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid/pharmacology
MH  - Aged
MH  - Amides/pharmacology
MH  - Calcium/metabolism
MH  - Calmodulin/antagonists & inhibitors/*metabolism
MH  - Enzyme Inhibitors/pharmacology
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Immunohistochemistry
MH  - In Vitro Techniques
MH  - Male
MH  - Muscle Contraction/drug effects
MH  - Muscle, Smooth/*drug effects/physiology
MH  - Prostate/*drug effects/physiology
MH  - Pyridines/pharmacology
MH  - Receptors, Thromboxane A2, Prostaglandin H2/agonists/physiology
MH  - Sulfonamides/pharmacology
MH  - Thromboxane A2/*pharmacology
MH  - Thromboxane-A Synthase/physiology
MH  - Vasoconstrictor Agents/pharmacology
MH  - rho-Associated Kinases/antagonists & inhibitors/*physiology
EDAT- 2010/11/04 06:00
MHDA- 2011/05/03 06:00
CRDT- 2010/11/04 06:00
PHST- 2010/06/21 00:00 [received]
PHST- 2010/10/04 00:00 [revised]
PHST- 2010/10/16 00:00 [accepted]
PHST- 2010/11/04 06:00 [entrez]
PHST- 2010/11/04 06:00 [pubmed]
PHST- 2011/05/03 06:00 [medline]
AID - S0014-2999(10)01079-4 [pii]
AID - 10.1016/j.ejphar.2010.10.052 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2011 Jan 15;650(2-3):650-5. doi: 10.1016/j.ejphar.2010.10.052.
      Epub 2010 Oct 31.


PMID- 21043549
OWN - NLM
STAT- MEDLINE
DCOM- 20110217
LR  - 20220318
IS  - 1445-6354 (Electronic)
IS  - 1445-6354 (Linking)
VI  - 10
IP  - 4
DP  - 2010 Oct-Dec
TI  - Self-efficacy beliefs and confidence of rural physiotherapists to undertake
      specialist paediatric caseloads: a paediatric example.
PG  - 1426
AB  - INTRODUCTION: Rural physiotherapists are faced with unique challenges, one of
      which is the necessity to extend their skills and knowledge to areas that would
      be covered by a specialist physiotherapist in an urban setting. The effects of
      this on the physiotherapist's confidence and self-belief has not been studied.
      The present study aimed to measure the self-efficacy and confidence of rural
      physiotherapists who undertake service delivery in the specialist field of
      paediatrics. METHOD: A descriptive, cross-sectional design survey was made of
      rural and remote physiotherapists working in north-west Queensland, Australia.
      Responses were coded and analysed using descriptive statistics and cross tabs to 
      compare existing relationships among variables. RESULTS: Twenty-three (of 56)
      completed surveys were returned (41% response rate). Rural and remote
      physiotherapist's are likely to be sole practitioners or part of a small group of
      clinicians, working full time in a hospital or private practice. These
      physiotherapists reported less peer support than urban physiotherapists and were 
      required to treat multiple cases across specialist areas. Physiotherapists
      working in such a demanding, unsupported environment have a low belief in their
      abilities and poor coping strategies, causing them to develop low self-efficacy. 
      CONCLUSION: Rural physiotherapists having low self-efficacy can mean they have
      low levels of confidence in their ability to practise, and hold the belief that
      they lack the skills and attributes to practice. This could mean a conflict with 
      professional conduct and ethical standards. Early identification of low
      self-efficacy gives time to review, develop and sustain strategies to help
      address the problems faced by the rural physiotherapist workforce, and to
      re-develop this workforce into one that is more stable and supportive.
FAU - Minisini, M
AU  - Minisini M
AD  - James Cook University, Townsville, Queensland, Australia.
      monica.minisini@jcu.edu.au
FAU - Sheppard, L A
AU  - Sheppard LA
FAU - Jones, A
AU  - Jones A
LA  - eng
PT  - Journal Article
DEP - 20101101
PL  - Australia
TA  - Rural Remote Health
JT  - Rural and remote health
JID - 101174860
SB  - IM
MH  - Adult
MH  - Child
MH  - Clinical Competence
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Physical Therapy Specialty/*organization & administration
MH  - Queensland
MH  - *Rural Health
MH  - *Self Efficacy
EDAT- 2010/11/04 06:00
MHDA- 2011/02/18 06:00
CRDT- 2010/11/04 06:00
PHST- 2010/11/04 06:00 [entrez]
PHST- 2010/11/04 06:00 [pubmed]
PHST- 2011/02/18 06:00 [medline]
AID - 1426 [pii]
PST - ppublish
SO  - Rural Remote Health. 2010 Oct-Dec;10(4):1426. Epub 2010 Nov 1.


PMID- 21043308
OWN - NLM
STAT- MEDLINE
DCOM- 20101130
LR  - 20101103
IS  - 0095-6562 (Print)
IS  - 0095-6562 (Linking)
VI  - 81
IP  - 11
DP  - 2010 Nov
TI  - Ethics in the workplace.
PG  - 1061
FAU - Sides, Marian B
AU  - Sides MB
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Aviat Space Environ Med
JT  - Aviation, space, and environmental medicine
JID - 7501714
SB  - IM
MH  - Aerospace Medicine/*ethics
MH  - Commerce/ethics
MH  - Humans
MH  - Organizations, Nonprofit/*ethics
MH  - *Workplace
EDAT- 2010/11/04 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/11/04 06:00
PHST- 2010/11/04 06:00 [entrez]
PHST- 2010/11/04 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - Aviat Space Environ Med. 2010 Nov;81(11):1061.


PMID- 21043158
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20101207
IS  - 0023-7205 (Print)
IS  - 0023-7205 (Linking)
VI  - 107
IP  - 37
DP  - 2010 Sep 15-21
TI  - [Ethics and politics: "The impartiality of the Swedish Medical Association is
      problematic"].
PG  - 2174-5
FAU - Alex-Petersen, Jesper
AU  - Alex-Petersen J
AD  - Lunds universitet, Malmo. jesper.petersen.511@student.lu.se
LA  - swe
PT  - Journal Article
TT  - Etik och politik: "Lakarforbundets obundenhet djupt problematisk".
PL  - Sweden
TA  - Lakartidningen
JT  - Lakartidningen
JID - 0027707
SB  - IM
CIN - Lakartidningen. 2010 Oct 13-19;107(41):2494; author reply 2494
MH  - Conflict of Interest
MH  - *Ethics, Medical
MH  - Evidence-Based Medicine
MH  - *Health Policy
MH  - Humans
MH  - *Societies, Medical
MH  - Socioeconomic Factors
MH  - Sweden
EDAT- 2010/11/04 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/11/04 06:00
PHST- 2010/11/04 06:00 [entrez]
PHST- 2010/11/04 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
PST - ppublish
SO  - Lakartidningen. 2010 Sep 15-21;107(37):2174-5.


PMID- 21043087
OWN - NLM
STAT- MEDLINE
DCOM- 20110901
LR  - 20111212
IS  - 0034-9887 (Print)
IS  - 0034-9887 (Linking)
VI  - 138
IP  - 7
DP  - 2010 Jul
TI  - [The teaching profession].
PG  - 902-7
AB  - This article focuses on understanding teaching activities, especially in the
      field of health science, as a set of tasks and actions that teachers undertake
      when transforming scientific knowledge into curriculum contents and actions.
      There are several ways to address this issue. Some authors identify specific
      roles and qualities of teachers structured as variables and dimensions. Others
      use the term competencies, applied as skills, aptitudes or abilities to do
      something very well or duly intervene in a certain matter. The term competence,
      although not yet clearly defined, is used in this work because it is widely used 
      in Health Sciences education. Some definitions are reviewed. Teacher's
      competencies in the following areas recognized: those related to specific
      professional skills, in contents organization, in learning skills, in new
      information and communication technologies, in evaluation and in social and
      ethical areas of educational practices.
FAU - Castillo, Manuel
AU  - Castillo M
AD  - Departamento de Educacion en Ciencias de la Salud, Facultad de Medicina de la
      Universidad de Chile, Santiago de Chile. mcastillo@med.uchile.cl
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - La profesion docente.
PL  - Chile
TA  - Rev Med Chil
JT  - Revista medica de Chile
JID - 0404312
SB  - IM
CIN - Rev Med Chil. 2011 Jun;139(6):814; author reply 814-5. PMID: 22051765
MH  - *Education, Medical
MH  - Humans
MH  - Professional Competence/*standards
MH  - Teaching/*standards
EDAT- 2010/11/04 06:00
MHDA- 2011/09/02 06:00
CRDT- 2010/11/04 06:00
PHST- 2010/11/04 06:00 [entrez]
PHST- 2010/11/04 06:00 [pubmed]
PHST- 2011/09/02 06:00 [medline]
PST - ppublish
SO  - Rev Med Chil. 2010 Jul;138(7):902-7.


PMID- 21043075
OWN - NLM
STAT- MEDLINE
DCOM- 20110901
LR  - 20191111
IS  - 0034-9887 (Print)
IS  - 0034-9887 (Linking)
VI  - 138
IP  - 7
DP  - 2010 Jul
TI  - [Analysis of a clinical ethics consultation experience in intensive care].
PG  - 815-20
AB  - BACKGROUND: Very few patients are presented to ethics committees, and individual 
      ethics consultations are a response to this situation. At the intensive care unit
      (ICU) in Clinica Alemana, Santiago Chile, an ethics consultation system was
      organized coordinated with the ethics committee. AIM: To report an evaluation of 
      this ethics consultation system. MATERIAL AND METHODS: Analysis of the first 50
      cases analyzed in the consultation system. Analysis of the responses of intensive
      care physicians to a questionnaire about the main ethical problems that they face
      in their work. RESULTS: The consultation system is mainly required by the ICU
      staff and reports to the ethics committee. Fifty four percent of patients
      subjected to consultation were aged over 80 years. The main diagnoses were
      neurological, oncological or cardiopulmonary problems. The ethical problems
      identified were treatment limitation (62%), proportionality or futility (42%),
      need of a peaceful death (36%), lack of anticipated decisions (28%), disagreement
      between physicians and patient's family (24%), undefined subrogation (14%), and
      abuse of public resources (14%). Twenty six of 31 ICU physicians answered the
      questionnaire, using a 1 (min) to 7 (max.) scale. They found that consultation is
      helpful for decision making (6.3), useful for improving ethical perception (6.0),
      supportive for staff (6.5), good for patients (6.3), supportive for families
      (6.7), and timely performed (5.2). CONCLUSIONS: As a complement for the ethics
      committee's work, consultation is a valid alternative for ethics counselling and 
      a support for physicians and patient's families. Its implementation depends on
      the particularities of each health institution.
FAU - Beca, Juan Pablo
AU  - Beca JP
AD  - Centro de Bioetica, Alemana Universidad del Desarrollo, Santiago de Chile,
      jpbeca@udd.cl
FAU - Koppmann, Alejandro
AU  - Koppmann A
FAU - Chavez, Pamela
AU  - Chavez P
FAU - Delgado, Iris
AU  - Delgado I
FAU - Solar, Sebastian
AU  - Solar S
LA  - spa
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - Analisis de una experiencia de consultoria etico clinica en cuidado intensive.
PL  - Chile
TA  - Rev Med Chil
JT  - Revista medica de Chile
JID - 0404312
SB  - IM
CIN - Rev Med Chil. 2010 Dec;138(12):1563. PMID: 21526309
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Chile
MH  - Consumer Behavior/statistics & numerical data
MH  - Critical Care/*ethics
MH  - *Ethics Committees, Clinical
MH  - Ethics Consultation/classification/standards/*statistics & numerical data
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
EDAT- 2010/11/04 06:00
MHDA- 2011/09/02 06:00
CRDT- 2010/11/04 06:00
PHST- 2010/11/04 06:00 [entrez]
PHST- 2010/11/04 06:00 [pubmed]
PHST- 2011/09/02 06:00 [medline]
AID - 10.4067/s0034-98872010000700004 [doi]
PST - ppublish
SO  - Rev Med Chil. 2010 Jul;138(7):815-20. doi: 10.4067/s0034-98872010000700004.


PMID- 21042659
OWN - NLM
STAT- MEDLINE
DCOM- 20101231
LR  - 20101102
IS  - 0720-9355 (Print)
IS  - 0720-9355 (Linking)
VI  - 30 Suppl 1
DP  - 2010 Nov
TI  - AHEAD. Advate in HaEmophilia A outcome Database.
PG  - S23-5
AB  - The clinical picture of haemophilia A patients is often characterised by
      recurrent bleedings, in particular joint bleeds. Thus far, long-term data on the 
      outcome of haemophilia A patients are scarce as regards the development of target
      joints, joint replacement, lost days from school or work due to bleedings, and
      the quality of life, as most previous studies were limited to the aspects of
      safety and efficacy. The Baxter-initiated AHEAD (Advate in HaEmophilia A outcome 
      Database) study is a multi-centre, prospective, non-interventional observational 
      study of haemophilia A patients. All patients with a residual FVIII activity of
      pound5% who are being treated with ADVATE are eligible. There are no limitations 
      in terms of patient age or treatment regimen. AHEAD is scientifically supported
      by a renowned interdisciplinary steering board and is intended to yield data on
      500 patients in up to 30 haemophilia centres, collected during a period of four
      years. The large patient population has been chosen in order to ensure a valid
      database. The objective of the study is to record haemophilia-related
      arthropathies, which will be defined based on imaging techniques (e. g. MRI,
      X-ray, ultrasound) and the judgment of the attending physician. In addition,
      extensive data will be collected on joint replacement surgeries, pseudotumour
      development, bleeding-related pain, quality of life (age-related questionnaires: 
      Haem-A-QoL, Haemo-QoL, SF10, SF12v2), risk factors (diabetes mellitus, arterial
      hypertension, nicotine abuse), blood group, gene mutation, physical activity, and
      on the efficacy and safety of Advate. The patient data will be entered into an
      electronic CRF system at the centres. Plausibility checks during data entry,
      regular monitoring visits, and the option of auditing all serve to ensure a high 
      data quality for AHEAD. The first patient was enrolled in the study in early June
      2010; recruitment is planned to continue until the end of 2011. The Ethics
      Committee of the University of Bonn has given its favorable opinion.
FAU - Oldenburg, J
AU  - Oldenburg J
AD  - Institute of Experimental Haematology and Transfusion Medicine, University
      Clinic, Sigmund-Freud-Str. 25, 53127 Bonn, Germany.
      johannes.oldenburg@ukb.uni-bonn.de
FAU - Kurnik, K
AU  - Kurnik K
FAU - Huth-Kuhne, A
AU  - Huth-Kuhne A
FAU - Zimmermann, R
AU  - Zimmermann R
FAU - Abraham, I
AU  - Abraham I
FAU - Klamroth, R
AU  - Klamroth R
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - Germany
TA  - Hamostaseologie
JT  - Hamostaseologie
JID - 8204531
RN  - 9001-27-8 (Factor VIII)
SB  - IM
MH  - Databases as Topic
MH  - Factor VIII/metabolism
MH  - Hemophilia A/complications/*therapy
MH  - Humans
MH  - Patient Selection
MH  - Prospective Studies
MH  - Treatment Outcome
EDAT- 2010/11/03 06:00
MHDA- 2011/01/01 06:00
CRDT- 2010/11/03 06:00
PHST- 2010/11/03 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/01/01 06:00 [medline]
AID - 10410S26 [pii]
PST - ppublish
SO  - Hamostaseologie. 2010 Nov;30 Suppl 1:S23-5.


PMID- 21042499
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1998-3948 (Electronic)
IS  - 1817-1745 (Linking)
VI  - 5
IP  - 1
DP  - 2010 Jan
TI  - Neurophysiologic findings in children with spastic cerebral palsy.
PG  - 12-7
LID - 10.4103/1817-1745.66671 [doi]
AB  - CONTEXT: Cerebral palsy (CP) is a heterogeneous group of permanent,
      non-progressive motor disorders of movement and posture caused by chronic brain
      injuries. It is the most common cause of physical disability in childhood;
      spastic cerebral palsy being the most prevalent of its various forms. There is
      scanty information about the neurophysiologic investigations in children
      diagnosed as having spastic CP. AIMS: The aim of the study was to investigate the
      relationship between abnormal VEP and BAEP findings with different clinical
      parameters in children with spastic cerebral palsy. MATERIALS AND METHODS:
      Fifteen children with spastic CP in the age range 4 months to 10 years
      participated in this study. Evaluation of VEPs, brainstem evoked potentials
      (BAEPs) were performed in all study patients as well as 35 healthy children as
      controls. The study was conducted after obtaining ethics committee approval and
      informed consent of parents. STATISTICAL ANALYSIS USED: Significance of
      difference in the mean values of different parameters in different groups was
      assessed by Student's "t" test and the P value <0.05 was considered to be
      significant. All the values were expressed as mean +/- 1 Std. Deviation. RESULTS:
      A significant difference was found in the VEP latencies and amplitude between the
      subjects with CP and controls. Striking BAEP abnormalities in CP patients include
      prolongation of absolute latency of wave V, interpeak latencies of III-V and
      lowered I-V ratio. Abnormal VEPs and BAEPs in children with bilateral spastic
      cerebral palsy demonstrated a correlation with the presence of moderate to severe
      developmental delay. CONCLUSIONS: The differences in VEPs and BAEPs were
      determined between CP children and healthy children. The abnormalities found are 
      probably linked to the neurological deficits present in cases of cerebral palsy.
FAU - Kothari, Ruchi
AU  - Kothari R
AD  - Department of Physiology, Mahatma Gandhi Institute of Medical Sciences, Sevagram,
      Wardha, India.
FAU - Singh, Ramji
AU  - Singh R
FAU - Singh, Smita
AU  - Singh S
FAU - Jain, Manish
AU  - Jain M
FAU - Bokariya, Pradeep
AU  - Bokariya P
FAU - Khatoon, Maria
AU  - Khatoon M
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Pediatr Neurosci
JT  - Journal of pediatric neurosciences
JID - 101273794
PMC - PMC2964783
OTO - NOTNLM
OT  - Brainstem evoked potential
OT  - developmental delay
OT  - spastic cerebral palsy
OT  - visual evoked potentials
EDAT- 2010/11/03 06:00
MHDA- 2010/11/03 06:01
CRDT- 2010/11/03 06:00
PHST- 2010/11/03 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2010/11/03 06:01 [medline]
AID - 10.4103/1817-1745.66671 [doi]
PST - ppublish
SO  - J Pediatr Neurosci. 2010 Jan;5(1):12-7. doi: 10.4103/1817-1745.66671.


PMID- 21042341
OWN - NLM
STAT- MEDLINE
DCOM- 20130516
LR  - 20181202
IS  - 1553-0779 (Electronic)
IS  - 1553-0779 (Linking)
VI  - 27
IP  - 5
DP  - 2010 Oct 29
TI  - NIH consensus development conference: Inhaled nitric oxide therapy for premature 
      infants.
PG  - 1-34
AB  - OBJECTIVE: To provide healthcare providers, patients, and the general public with
      a responsible assessment of currently available data on the use of inhaled nitric
      oxide in early routine, early rescue, or later rescue regimens in the care of
      premature infants <34 weeks gestation who require respiratory support.
      PARTICIPANTS: A non-Department of Health and Human Services, nonadvocate
      16-member panel representing the fields of biostatistics, child psychology,
      clinical trials, ethics, family-centered care, neonatology, neurodevelopmental
      follow-up, nursing, pediatric epidemiology, neurobehavior, neurological surgery, 
      neurology, and pulmonology, perinatology, and research methodology. In addition, 
      18 experts from pertinent fields presented data to the panel and conference
      audience. EVIDENCE: Presentations by experts and a systematic review of the
      literature prepared by the Johns Hopkins University Evidence-based Practice
      Center, through the Agency for Healthcare Research and Quality. Scientific
      evidence was given precedence over anecdotal experience. CONFERENCE PROCESS: The 
      panel drafted its statement based on scientific evidence presented in open forum 
      and on published scientific literature. The draft statement was presented on the 
      final day of the conference and circulated to the audience for comment. The panel
      released a revised statement later that day at http://consensus.nih.gov. This
      statement is a report of the panel and is not a policy statement of the NIH or
      the Federal Government. CONCLUSIONS: (1) Taken as a whole, the available evidence
      does not support use of inhaled nitric oxide in early routine, early rescue, or
      later rescue regimens in the care of premature infants <34 weeks gestation who
      require respiratory support. (2) There are rare clinical situations, including
      pulmonary hypertension or hypoplasia, that have been inadequately studied in
      which inhaled nitric oxide may have benefit in infants <34 weeks gestation. In
      such situations, clinicians should communicate with families regarding the
      current evidence on its risks and benefits as well as remaining uncertainties.
      (3) Basic research and animal studies have contributed to important
      understandings of inhaled nitric oxide benefits on lung development and function 
      in infants at high risk of bronchopulmonary dysplasia. These promising results
      have only partly been realized in clinical trials of inhaled nitric oxide
      treatment in premature infants. Future research should seek to understand this
      gap. (4) Predefined subgroup and post hoc analyses of previous trials showing
      potential benefit of inhaled nitric oxide have generated hypotheses for future
      research for clinical trials. Prior strategies shown to be ineffective are
      discouraged unless new evidence emerges. The positive results of one multicenter 
      trial, which was characterized by later timing, higher dose, and longer duration 
      of treatment, require confirmation. Future trials should attempt to quantify the 
      individual effects of each of these treatment-related variables (timing, dose,
      and duration), ideally by randomizing them separately. (5) Based on assessment of
      currently available data, hospitals, clinicians, and the pharmaceutical industry 
      should avoid marketing inhaled nitric oxide for premature infants <34 weeks
      gestation.
FAU - Cole, F Sessions
AU  - Cole FS
AD  - Department of Pediatrics, Division of Newborn Medicine, Washington University
      School of Medicine, and St. Louis Children's Hospital, St. Louis, Missouri, USA.
FAU - Alleyne, Claudia
AU  - Alleyne C
FAU - Barks, John D E
AU  - Barks JD
FAU - Boyle, Robert J
AU  - Boyle RJ
FAU - Carroll, John L
AU  - Carroll JL
FAU - Dokken, Deborah
AU  - Dokken D
FAU - Edwards, William H
AU  - Edwards WH
FAU - Georgieff, Michael
AU  - Georgieff M
FAU - Gregory, Katherine
AU  - Gregory K
FAU - Johnston, Michael V
AU  - Johnston MV
FAU - Kramer, Michael
AU  - Kramer M
FAU - Mitchell, Christine
AU  - Mitchell C
FAU - Neu, Josef
AU  - Neu J
FAU - Pursley, DeWayne M
AU  - Pursley DM
FAU - Robinson, Walter
AU  - Robinson W
FAU - Rowitch, David H
AU  - Rowitch DH
LA  - eng
PT  - Consensus Development Conference, NIH
PT  - Journal Article
PT  - Review
PT  - Systematic Review
PL  - United States
TA  - NIH Consens State Sci Statements
JT  - NIH consensus and state-of-the-science statements
JID - 101160100
RN  - 0 (Bronchodilator Agents)
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - IM
MH  - Administration, Inhalation
MH  - Bronchodilator Agents/*administration & dosage
MH  - Clinical Trials as Topic
MH  - Evidence-Based Medicine
MH  - Humans
MH  - Infant, Newborn
MH  - *Infant, Premature
MH  - Nitric Oxide/*administration & dosage
MH  - Practice Guidelines as Topic
MH  - Respiratory Distress Syndrome, Newborn/*drug therapy/prevention & control
MH  - Risk Assessment
MH  - Risk Factors
MH  - Treatment Outcome
MH  - United States
EDAT- 2010/11/03 06:00
MHDA- 2013/05/17 06:00
CRDT- 2010/11/03 06:00
PHST- 2010/11/03 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2013/05/17 06:00 [medline]
AID - 2010-000123-STMT [pii]
PST - ppublish
SO  - NIH Consens State Sci Statements. 2010 Oct 29;27(5):1-34.


PMID- 21042271
OWN - NLM
STAT- MEDLINE
DCOM- 20110301
LR  - 20101102
IS  - 0026-4946 (Print)
IS  - 0026-4946 (Linking)
VI  - 62
IP  - 6
DP  - 2010 Dec
TI  - [Plastic and esthetic surgery on children with Down's syndrome: ethical and
      technical aspects].
PG  - 585-90
AB  - One of the most commonly shared characteristics of children with Down's syndrome 
      is the effect on facial features. The vast majority of children with Down's
      syndrome have an epicanthal folds, a slanted palpebral fissures and a flattened
      nasal bridge. Another common feature is a protruding tongue with an open mouth.
      The surgeries can be categorized into two groups: techniques aimed at reducing
      the size of the tongue, and surgeries aimed at improving the appearance of the
      face, called "facial reconstruction". Indications and limits of these categories 
      are discussed separately. Moreover, the tongue reduction presents further
      anesthesiological problems. Parents should be not pressured into consenting to
      plastic surgery, and plastic surgery should never be considered a stand-alone
      therapy. Parents should get all information about the procedures, including
      risks, performed on their children to best make an informed decision, also in
      order to avoid unnecessary pain to the children and the adolescents with Down's
      syndrome.
FAU - Abbate, B
AU  - Abbate B
AD  - Ospedale Pediatrico Anna Meyer, Azienda Ospedaliero Universitaria, Firenze,
      Italia.
LA  - ita
PT  - English Abstract
PT  - Journal Article
TT  - La chirurgia plastica estetica nei bambini con sindrome di Down: aspetti tecnici 
      ed etici.
PL  - Italy
TA  - Minerva Pediatr
JT  - Minerva pediatrica
JID - 0400740
SB  - IM
MH  - Child
MH  - Down Syndrome/*surgery
MH  - Humans
MH  - Reconstructive Surgical Procedures/*ethics/*methods
EDAT- 2010/11/03 06:00
MHDA- 2011/03/02 06:00
CRDT- 2010/11/03 06:00
PHST- 2010/11/03 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/03/02 06:00 [medline]
AID - R15103344 [pii]
PST - ppublish
SO  - Minerva Pediatr. 2010 Dec;62(6):585-90.


PMID- 21042256
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20161125
IS  - 0966-0461 (Print)
IS  - 0966-0461 (Linking)
VI  - 19
IP  - 19
DP  - 2010 Oct 28-Nov 10
TI  - The Bonfire of the Regulators: the HFEA an unjustified death?
PG  - 1256-7
AB  - The Government has confirmed that the Human Fertilisation and Embryology
      Authority is to be abolished with a number of its functions transferred to other 
      bodies as part of the 'bonfire of the quangos'. This article explores these
      proposals and questions whether such wide-scale reform is an appropriate approach
      to the regulating of what remains such an ethically controversial area.
FAU - McHale, Jean
AU  - McHale J
AD  - Birmingham Law School.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Nurs
JT  - British journal of nursing (Mark Allen Publishing)
JID - 9212059
MH  - Embryo Research
MH  - Embryology
MH  - Facility Regulation and Control/*organization & administration
MH  - Forecasting
MH  - Government Regulation
MH  - Health Care Reform/*organization & administration
MH  - Health Facility Closure/*trends
MH  - Health Planning Guidelines
MH  - Humans
MH  - Organizational Objectives
MH  - Reproductive Techniques, Assisted/ethics/*trends
MH  - State Medicine/*organization & administration
MH  - United Kingdom
EDAT- 2010/11/03 06:00
MHDA- 2011/01/07 06:00
CRDT- 2010/11/03 06:00
PHST- 2010/11/03 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
AID - 10.12968/bjon.2010.19.19.79286 [doi]
PST - ppublish
SO  - Br J Nurs. 2010 Oct 28-Nov 10;19(19):1256-7. doi: 10.12968/bjon.2010.19.19.79286.


PMID- 21042034
OWN - NLM
STAT- MEDLINE
DCOM- 20110302
LR  - 20191210
IS  - 1423-0208 (Electronic)
IS  - 0251-5350 (Linking)
VI  - 35
IP  - 4
DP  - 2010
TI  - An introduction to instrumental variables--part 2: Mendelian randomisation.
PG  - 307-10
LID - 10.1159/000321179 [doi]
AB  - In the first part of this series, it was highlighted how even though randomised
      controlled trials can provide robust evidence for therapeutic interventions, for 
      many types of exposure it may not be either practical or ethical to randomise
      patients to such studies (see part 1). Instrumental variables (IV) analyses have 
      been increasingly employed in recent times in epidemiology to investigate the
      potential causal effects of an exposure. An IV is a variable that can
      realistically mimic the treatment allocation process in a randomised study and is
      assumed to be not directly related to outcome, except through the direct effect
      of treatment and not related to outcome through either measured or unmeasured
      confounders. As discussed in the first article, IV analyses can be useful in
      estimating direct treatment effects provided that the chosen instrument is
      strong. A particular type of IV analysis where a specific genetic variant has
      been used as the instrument known as 'Mendelian randomisation' has become
      increasingly common. The aim of the second part of this statistical primer is to 
      outline the approach to Mendelian randomisation and some of the advantages and
      disadvantages of this approach.
CI  - Copyright (c) 2010 S. Karger AG, Basel.
FAU - Bennett, Derrick A
AU  - Bennett DA
AD  - Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
      derrick.bennett@ctsu.ox.ac.uk
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20101029
PL  - Switzerland
TA  - Neuroepidemiology
JT  - Neuroepidemiology
JID - 8218700
RN  - 0 (Biomarkers)
SB  - IM
MH  - Bias
MH  - Biomarkers/blood
MH  - Confounding Factors, Epidemiologic
MH  - Data Interpretation, Statistical
MH  - *Epidemiologic Methods
MH  - Humans
MH  - Mendelian Randomization Analysis/*standards/*statistics & numerical data
MH  - Nervous System Diseases/*epidemiology/genetics/therapy
MH  - Randomized Controlled Trials as Topic
EDAT- 2010/11/03 06:00
MHDA- 2011/03/03 06:00
CRDT- 2010/11/03 06:00
PHST- 2010/04/19 00:00 [received]
PHST- 2010/09/09 00:00 [accepted]
PHST- 2010/11/03 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/03/03 06:00 [medline]
AID - 000321179 [pii]
AID - 10.1159/000321179 [doi]
PST - ppublish
SO  - Neuroepidemiology. 2010;35(4):307-10. doi: 10.1159/000321179. Epub 2010 Oct 29.


PMID- 21041805
OWN - NLM
STAT- MEDLINE
DCOM- 20110330
LR  - 20101220
IS  - 1744-5019 (Electronic)
IS  - 0360-5310 (Linking)
VI  - 35
IP  - 6
DP  - 2010 Dec
TI  - Enhancing who? Enhancing what? Ethics, bioethics, and transhumanism.
PG  - 685-99
LID - 10.1093/jmp/jhq051 [doi]
AB  - Transhumanists advance a "posthuman" condition in which technological and genetic
      enhancements will transform humankind. They are joined in this goal by
      bioethicists arguing for genetic selection as a means of "enhancing evolution,"
      improving if not also the species then at least the potential lives of future
      individuals. The argument of both, this paper argues, is a new riff on the old
      eugenics tune. As ever, it is done in the name of science and its presumed
      knowledge base. As ever, the result is destructive rather than instructive, bad
      faith promoted as high ideal. The paper concludes with the argument that species 
      advancement is possible but in a manner thoroughly distinct from that advanced by
      either of these groups.
FAU - Koch, Tom
AU  - Koch T
AD  - Information Outreach, Ltd., 136 Hammersmith Ave., Toronto, Ontario, Canada.
      tomkoch@interchange.ubc.ca
LA  - eng
PT  - Journal Article
DEP - 20101101
PL  - United States
TA  - J Med Philos
JT  - The Journal of medicine and philosophy
JID - 7610512
SB  - IM
MH  - *Bioethical Issues
MH  - Biomedical Engineering/*ethics
MH  - Eugenics
MH  - *Humanism
MH  - Humans
MH  - *Philosophy, Medical
EDAT- 2010/11/03 06:00
MHDA- 2011/03/31 06:00
CRDT- 2010/11/03 06:00
PHST- 2010/11/03 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/03/31 06:00 [medline]
AID - jhq051 [pii]
AID - 10.1093/jmp/jhq051 [doi]
PST - ppublish
SO  - J Med Philos. 2010 Dec;35(6):685-99. doi: 10.1093/jmp/jhq051. Epub 2010 Nov 1.


PMID- 21041466
OWN - NLM
STAT- MEDLINE
DCOM- 20110426
LR  - 20220310
IS  - 1545-7230 (Electronic)
IS  - 1042-9670 (Linking)
VI  - 34
IP  - 6
DP  - 2010 Nov-Dec
TI  - Canadian residents teaching and learning psychiatry in Ethiopia: a grounded
      theory analysis focusing on their experiences.
PG  - 433-7
LID - 10.1176/appi.ap.34.6.433 [doi]
AB  - OBJECTIVES: The Toronto Addis Ababa Psychiatry Project (TAAPP) is an
      international collaboration between University of Toronto and Addis Ababa
      University. University of Toronto psychiatric residents may participate in TAAPP 
      as an elective. The authors explored the Canadian resident experience in a
      qualitative study of the project. METHODS: Eleven residents were interviewed
      using a semistructured questionnaire. Grounded theory was employed to organize
      participants' experiences and highlight emerging themes. The computer software
      NVivo7 was used to facilitate data analysis. RESULTS: Participants described
      gaining competency as health advocates, collaborators, scholars, and teachers.
      They endorsed increased sensitivity to cross-cultural issues and greater
      awareness of global health issues, including practical and ethical ramifications 
      of working at an intersection of cultures. Residents gained international
      perspective psychiatric practice. CONCLUSION: The elective provided unique
      opportunities for acquiring clinical, teaching, collaborative, leadership and
      advocacy skills. It prompted participants to consider ethical and cross-cultural 
      issues and allowed them to be mentored intensively by Ethiopian and Canadian
      teachers and peers.
FAU - Brook, Shelley
AU  - Brook S
AD  - Department of Psychiatry at University Health Network in Toronto, Ontario.
      brooksh@smh.toronto.on.ca
FAU - Robertson, David
AU  - Robertson D
FAU - Makuwaza, Tutsirai
AU  - Makuwaza T
FAU - Hodges, Brian D
AU  - Hodges BD
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Acad Psychiatry
JT  - Academic psychiatry : the journal of the American Association of Directors of
      Psychiatric Residency Training and the Association for Academic Psychiatry
JID - 8917200
SB  - IM
CIN - Acad Psychiatry. 2010 Nov-Dec;34(6):414-6. PMID: 21041463
MH  - *Area Health Education Centers/ethics/organization & administration
MH  - Canada
MH  - Computing Methodologies
MH  - Cooperative Behavior
MH  - *Cultural Diversity
MH  - *Delegation, Professional/ethics/organization & administration
MH  - Education, Medical, Graduate/ethics/organization & administration
MH  - Ethiopia
MH  - Evaluation Studies as Topic
MH  - *Foreign Professional Personnel/education/supply & distribution
MH  - Humans
MH  - Internationality
MH  - Psychiatry/*education/ethics
MH  - Teaching
MH  - Workforce
EDAT- 2010/11/03 06:00
MHDA- 2011/04/27 06:00
CRDT- 2010/11/03 06:00
PHST- 2010/11/03 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/04/27 06:00 [medline]
AID - 34/6/433 [pii]
AID - 10.1176/appi.ap.34.6.433 [doi]
PST - ppublish
SO  - Acad Psychiatry. 2010 Nov-Dec;34(6):433-7. doi: 10.1176/appi.ap.34.6.433.


PMID- 21041421
OWN - NLM
STAT- MEDLINE
DCOM- 20110217
LR  - 20161020
IS  - 1526-3347 (Electronic)
IS  - 0191-9601 (Linking)
VI  - 31
IP  - 11
DP  - 2010 Nov
TI  - Ethics for the pediatician: disorders of sex development: optimizing care.
PG  - e82-5
LID - 10.1542/pir.31-11-e82 [doi]
FAU - Karkazis, Katrina
AU  - Karkazis K
AD  - Center for Biomedical Ethics, Stanford University, Palo Alto, Calif., USA.
FAU - Rossi, Wilma C
AU  - Rossi WC
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Pediatr Rev
JT  - Pediatrics in review
JID - 8103046
SB  - IM
MH  - Decision Making
MH  - Disorders of Sex Development/*therapy
MH  - *Ethics, Clinical
MH  - Gender Identity
MH  - Genitalia/surgery
MH  - Humans
MH  - Patient Care Team
EDAT- 2010/11/03 06:00
MHDA- 2011/02/18 06:00
CRDT- 2010/11/03 06:00
PHST- 2010/11/03 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/02/18 06:00 [medline]
AID - 31/11/e82 [pii]
AID - 10.1542/pir.31-11-e82 [doi]
PST - ppublish
SO  - Pediatr Rev. 2010 Nov;31(11):e82-5. doi: 10.1542/pir.31-11-e82.


PMID- 21041237
OWN - NLM
STAT- MEDLINE
DCOM- 20110429
LR  - 20220311
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 1
DP  - 2011 Jan
TI  - Muslim patients and cross-gender interactions in medicine: an Islamic bioethical 
      perspective.
PG  - 40-4
LID - 10.1136/jme.2010.037614 [doi]
AB  - As physicians encounter an increasingly diverse patient population, socioeconomic
      circumstances, religious values and cultural practices may present barriers to
      the delivery of quality care. Increasing cultural competence is often cited as a 
      way to reduce healthcare disparities arising from value and cultural differences 
      between patients and providers. Cultural competence entails not only a knowledge 
      base of cultural practices of disparate patient populations, but also an attitude
      of adapting one's practice style to meet patient needs and values. Gender roles, 
      relationship dynamics and boundaries are culture specific, and are frequently
      shaped by religious teachings. Consequently, religion may be conceptualised as a 
      cultural repertoire, or dynamic tool-kit, by which members of a faith adapt and
      negotiate their identity in multicultural societies. The manner in which Islamic 
      beliefs and values inform Muslim healthcare behaviours is relatively
      under-investigated. In an effort to explore the impact of Islam on the
      relationship between patients and providers, we present an Islamic bioethical
      perspective on cross-gender relations in the patient-doctor relationship. We will
      begin with a clinical scenario highlighting three areas of gender interaction
      that bear clinical relevance: dress code, seclusion of members of the opposite
      sex and physical contact. Next, we provide a brief overview of the foundations of
      Islamic law and ethical deliberation and then proceed to develop ethicolegal
      guidelines pertaining to gender relations within the medical context. At the end 
      of this reflection, we offer some practice recommendations that are attuned to
      the cultural sensitivities of Muslim patient populations.
FAU - Padela, Aasim I
AU  - Padela AI
AD  - Robert Wood Johnson Foundation Clinical Scholars Program, Department of General
      Internal Medicine, University of Michigan, Ann Arbor, MI 48109-5604, USA.
      aasim@umich.edu
FAU - Rodriguez del Pozo, Pablo
AU  - Rodriguez del Pozo P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101101
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Cultural Characteristics
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Islam/*psychology
MH  - Male
MH  - Patient Compliance/*psychology
MH  - *Physical Examination/ethics/psychology
MH  - *Physician-Patient Relations
MH  - Professional Practice/ethics
MH  - *Religion and Medicine
MH  - *Sex Factors
EDAT- 2010/11/03 06:00
MHDA- 2011/04/30 06:00
CRDT- 2010/11/03 06:00
PHST- 2010/11/03 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/04/30 06:00 [medline]
AID - jme.2010.037614 [pii]
AID - 10.1136/jme.2010.037614 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Jan;37(1):40-4. doi: 10.1136/jme.2010.037614. Epub 2010 Nov 1.


PMID- 21041038
OWN - NLM
STAT- MEDLINE
DCOM- 20110523
LR  - 20110111
IS  - 1532-2777 (Electronic)
IS  - 0306-9877 (Linking)
VI  - 76
IP  - 2
DP  - 2011 Feb
TI  - A novel method to inhibit apoptosis and promote differentiation of induced
      pluripotent stem cells in transplantation therapy for myocardial infarction.
PG  - 264-5
LID - 10.1016/j.mehy.2010.10.016 [doi]
AB  - Myocardial ischemic disorders are the leading causes of mortality worldwide, and 
      current therapies only delay progression of these diseases. Traditional stem cell
      therapies face various impediments, including the typical ethical and
      immunological problems in clinical application. Recently, induced pluripotent
      stem (iPS) cells have been shown to offer a novel fascinating route to
      patient-specific and disease-specific pluripotent cells, without the technical
      and ethical limitations of somatic cell nuclear transfer method. However, iPS
      cells' limited viability after transplantation in infarcted microenvironment, and
      low rate of differentiation into cardiovascular tissues restricts their
      regenerative capacity. Genetically modified iPS cells with the recently
      discovered cellular repressor of E1A-stimulated genes (CREG), which inhibits
      apoptosis and inflammation but enhances differentiation, may resolve these
      crucial problems. Possible mechanisms may include CREG promotion of angiogenesis 
      by VEGF, suppression of inflammation and resistance of apoptosis via activating
      PI3K/Akt and blocking p38 MARK signaling, and maintenance of endothelial
      differentiation conditions. The exact mechanisms that CREG can modulate iPS
      cells' survival and differentiation remain to be investigated.
CI  - Copyright A(c) 2010. Published by Elsevier Ltd.
FAU - Li, Jie
AU  - Li J
AD  - Department of Cardiology, Xijing Hospital, Fourth Military Medical University, 17
      Changle Road, 710032 Xi'an, Shaanxi, China.
FAU - Han, Yaling
AU  - Han Y
FAU - Yan, Chenhui
AU  - Yan C
FAU - Kang, Jian
AU  - Kang J
FAU - Peng, Chengfei
AU  - Peng C
FAU - Zhang, Na
AU  - Zhang N
FAU - Zhang, Huimin
AU  - Zhang H
LA  - eng
PT  - Journal Article
DEP - 20101030
PL  - United States
TA  - Med Hypotheses
JT  - Medical hypotheses
JID - 7505668
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Animals
MH  - *Apoptosis
MH  - *Cell Differentiation
MH  - Cell Survival
MH  - Cell Transplantation/*methods
MH  - Disease Progression
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*cytology
MH  - Inflammation
MH  - Mice
MH  - Models, Theoretical
MH  - Myocardial Infarction/*metabolism/prevention & control
MH  - Signal Transduction
MH  - p38 Mitogen-Activated Protein Kinases/metabolism
EDAT- 2010/11/03 06:00
MHDA- 2011/05/24 06:00
CRDT- 2010/11/03 06:00
PHST- 2010/04/20 00:00 [received]
PHST- 2010/10/06 00:00 [revised]
PHST- 2010/10/10 00:00 [accepted]
PHST- 2010/11/03 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/05/24 06:00 [medline]
AID - S0306-9877(10)00427-5 [pii]
AID - 10.1016/j.mehy.2010.10.016 [doi]
PST - ppublish
SO  - Med Hypotheses. 2011 Feb;76(2):264-5. doi: 10.1016/j.mehy.2010.10.016. Epub 2010 
      Oct 30.


PMID- 21040491
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20220317
IS  - 1743-6109 (Electronic)
IS  - 1743-6095 (Linking)
VI  - 7
IP  - 11
DP  - 2010 Nov
TI  - Summary of the recommendations on sexual dysfunctions in men.
PG  - 3572-88
LID - 10.1111/j.1743-6109.2010.02062.x [doi]
AB  - INTRODUCTION: Sexual health is an integral part of overall health. Sexual
      dysfunction can have a major impact on quality of life and psychosocial and
      emotional well-being. AIM: To provide evidence-based, expert-opinion consensus
      guidelines for clinical management of sexual dysfunction in men. METHODS: An
      international consultation collaborating with major urologic and sexual medicine 
      societies convened in Paris, July 2009. More than 190 multidisciplinary experts
      from 33 countries were assembled into 25 consultation committees. Committee
      members established scope and objectives for each chapter. Following an
      exhaustive review of available data and publications, committees developed
      evidence-based guidelines in each area. Main Outcome Measures. New algorithms and
      guidelines for assessment and treatment of sexual dysfunctions were developed
      based on work of previous consultations and evidence from scientific literature
      published from 2003 to 2009. The Oxford system of evidence-based review was
      systematically applied. Expert opinion was based on systematic grading of medical
      literature, and cultural and ethical considerations. RESULTS: Algorithms,
      recommendations, and guidelines for sexual dysfunction in men are presented.
      These guidelines were developed in an evidence-based, patient-centered,
      multidisciplinary manner. It was felt that all sexual dysfunctions should be
      evaluated and managed following a uniform strategy, thus the International
      Consultation of Sexual Medicine (ICSM-5) developed a stepwise diagnostic and
      treatment algorithm for sexual dysfunction. The main goal of ICSM-5 is to unmask 
      the underlying etiology and/or indicate appropriate treatment options according
      to men's and women's individual needs (patient-centered medicine) using the best 
      available data from population-based research (evidence-based medicine). Specific
      evaluation, treatment guidelines, and algorithms were developed for every sexual 
      dysfunction in men, including erectile dysfunction; disorders of libido, orgasm, 
      and ejaculation; Peyronie's disease; and priapism. CONCLUSIONS: Sexual
      dysfunction in men represents a group of common medical conditions that need to
      be managed from a multidisciplinary perspective.
CI  - (c) 2010 International Society for Sexual Medicine.
FAU - Montorsi, Francesco
AU  - Montorsi F
AD  - Department of Urology, San Raffaele Hospital, Milan, Italy.
      montorsi.francesco@hsr.it
FAU - Adaikan, Ganesan
AU  - Adaikan G
FAU - Becher, Edgardo
AU  - Becher E
FAU - Giuliano, Francois
AU  - Giuliano F
FAU - Khoury, Saad
AU  - Khoury S
FAU - Lue, Tom F
AU  - Lue TF
FAU - Sharlip, Ira
AU  - Sharlip I
FAU - Althof, Stanley E
AU  - Althof SE
FAU - Andersson, Karl-Eric
AU  - Andersson KE
FAU - Brock, Gerald
AU  - Brock G
FAU - Broderick, Gregory
AU  - Broderick G
FAU - Burnett, Arthur
AU  - Burnett A
FAU - Buvat, Jacques
AU  - Buvat J
FAU - Dean, John
AU  - Dean J
FAU - Donatucci, Craig
AU  - Donatucci C
FAU - Eardley, Ian
AU  - Eardley I
FAU - Fugl-Meyer, Kerstin S
AU  - Fugl-Meyer KS
FAU - Goldstein, Irwin
AU  - Goldstein I
FAU - Hackett, Geoff
AU  - Hackett G
FAU - Hatzichristou, Dimitris
AU  - Hatzichristou D
FAU - Hellstrom, Wayne
AU  - Hellstrom W
FAU - Incrocci, Luca
AU  - Incrocci L
FAU - Jackson, Graham
AU  - Jackson G
FAU - Kadioglu, Ates
AU  - Kadioglu A
FAU - Levine, Laurence
AU  - Levine L
FAU - Lewis, Ronald W
AU  - Lewis RW
FAU - Maggi, Mario
AU  - Maggi M
FAU - McCabe, Marita
AU  - McCabe M
FAU - McMahon, Chris G
AU  - McMahon CG
FAU - Montague, Drogo
AU  - Montague D
FAU - Montorsi, Piero
AU  - Montorsi P
FAU - Mulhall, John
AU  - Mulhall J
FAU - Pfaus, Jim
AU  - Pfaus J
FAU - Porst, Hartmut
AU  - Porst H
FAU - Ralph, David
AU  - Ralph D
FAU - Rosen, Raymond
AU  - Rosen R
FAU - Rowland, David
AU  - Rowland D
FAU - Sadeghi-Nejad, Hossein
AU  - Sadeghi-Nejad H
FAU - Shabsigh, Ridwan
AU  - Shabsigh R
FAU - Stief, Christian
AU  - Stief C
FAU - Vardi, Yoram
AU  - Vardi Y
FAU - Wallen, Kim
AU  - Wallen K
FAU - Wasserman, Marlene
AU  - Wasserman M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - J Sex Med
JT  - The journal of sexual medicine
JID - 101230693
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - Ejaculation
MH  - Erectile Dysfunction/pathology/psychology/surgery
MH  - Evidence-Based Medicine
MH  - Expert Testimony
MH  - Humans
MH  - Impotence, Vasculogenic/pathology/*psychology/surgery
MH  - Male
MH  - Penile Induration
MH  - Practice Guidelines as Topic
MH  - Prostatic Neoplasms
MH  - Risk Factors
MH  - Testosterone/deficiency
MH  - Time Factors
EDAT- 2010/11/03 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/11/03 06:00
PHST- 2010/11/03 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - 10.1111/j.1743-6109.2010.02062.x [doi]
AID - S1743-6095(15)32743-0 [pii]
PST - ppublish
SO  - J Sex Med. 2010 Nov;7(11):3572-88. doi: 10.1111/j.1743-6109.2010.02062.x.


PMID- 21040456
OWN - NLM
STAT- MEDLINE
DCOM- 20110324
LR  - 20211020
IS  - 1582-4934 (Electronic)
IS  - 1582-1838 (Linking)
VI  - 14
IP  - 12
DP  - 2010 Dec
TI  - Natural stem cell transplantation: interventions, nuances and ethics.
PG  - 2840-1
LID - 10.1111/j.1582-4934.2010.01199.x [doi]
FAU - Bewley, Susan
AU  - Bewley S
FAU - Diaz-Rossello, Jose Luis
AU  - Diaz-Rossello JL
FAU - Mercer, Judith
AU  - Mercer J
LA  - eng
PT  - Comment
PT  - Letter
PL  - England
TA  - J Cell Mol Med
JT  - Journal of cellular and molecular medicine
JID - 101083777
SB  - IM
CON - J Cell Mol Med. 2010 Mar;14(3):488-95. PMID: 20141549
MH  - Constriction
MH  - Cord Blood Stem Cell Transplantation
MH  - Female
MH  - Fetal Blood/*cytology
MH  - *Hematopoietic Stem Cells
MH  - Humans
MH  - Perinatal Care
MH  - *Pluripotent Stem Cells
MH  - Pregnancy
MH  - *Umbilical Cord
PMC - PMC3822733
EDAT- 2010/11/03 06:00
MHDA- 2011/03/25 06:00
CRDT- 2010/11/03 06:00
PHST- 2010/11/03 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/03/25 06:00 [medline]
AID - 10.1111/j.1582-4934.2010.01199.x [doi]
PST - ppublish
SO  - J Cell Mol Med. 2010 Dec;14(12):2840-1. doi: 10.1111/j.1582-4934.2010.01199.x.


PMID- 21040259
OWN - NLM
STAT- MEDLINE
DCOM- 20110301
LR  - 20101102
IS  - 1478-5153 (Electronic)
IS  - 1362-1017 (Linking)
VI  - 15
IP  - 6
DP  - 2010 Nov-Dec
TI  - Critical care: does profusion of evidence lead to confusion in practice?
PG  - 285-90
LID - 10.1111/j.1478-5153.2010.00415.x [doi]
AB  - There have been a plethora of articles on evidence-based practice or its many
      derivative terms (evidence-based nursing, evidence-based medicine, evidence-based
      health care, etc.). However, the word 'based' implies an almost unquestioning
      belief in evidence. I will argue that the term 'Evidence Informed Practice' is
      probably more accurate. This argument will be underpinned by Archie Cochrane's
      'road to Damascus' questioning of the value of soft over hard interventions and
      challenge what is held up as gold-standard evidence. The differences in
      definitions of evidence-based practice will also be discussed. Carper's
      identification of ethical, aesthetic and personal knowing will be used to debunk 
      the myth that empirical evidence is always the gold standard for care and
      treatment. It will be argued that empirical evidence can be ignored when it
      clashes with other types of evidence. Finally, the tension between certainty and 
      agreement with evidence will be explored.
CI  - (c) 2010 The Author. Nursing in Critical Care (c) 2010 British Association of
      Critical Care Nurses.
FAU - McKenna, Hugh
AU  - McKenna H
AD  - Faculty of Life & Health Sciences, University of Ulster, Coleraine, County
      Londonderry BT52 1SA, UK. hp.mckenna@ulster.ac.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Crit Care
JT  - Nursing in critical care
JID - 9808649
MH  - *Clinical Nursing Research
MH  - *Critical Care/standards
MH  - *Evidence-Based Practice/standards
MH  - Humans
EDAT- 2010/11/03 06:00
MHDA- 2011/03/02 06:00
CRDT- 2010/11/03 06:00
PHST- 2010/11/03 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/03/02 06:00 [medline]
AID - 10.1111/j.1478-5153.2010.00415.x [doi]
PST - ppublish
SO  - Nurs Crit Care. 2010 Nov-Dec;15(6):285-90. doi: 10.1111/j.1478-5153.2010.00415.x.


PMID- 21040220
OWN - NLM
STAT- MEDLINE
DCOM- 20110304
LR  - 20101102
IS  - 1365-2850 (Electronic)
IS  - 1351-0126 (Linking)
VI  - 17
IP  - 9
DP  - 2010 Nov
TI  - Covert administration of medication to older adults: a review of the literature
      and published studies.
PG  - 761-8
LID - 10.1111/j.1365-2850.2010.01613.x [doi]
AB  - The aim of the study was to review published studies of covert medicines
      administration in older people, as well as carrying out a broad review of the
      subject. A review of MEDLINE, EMBASE, PsycINFO, BNI and CINAHL was conducted in
      order to identify studies providing quantitative or qualitative data on covert
      administration in older adults. National guidance on covert medication and the
      ethics and legality of the practice were also reviewed. Data were extracted from 
      eight studies and one inspection report. In addition, one qualitative study was
      identified. Nine studies included a questionnaire or interview with staff and
      only one involved non-professional carers. Seven studies were from the UK.
      Disguising medication in food or drink was reported in 43-71% of nursing homes.
      In total, 1.5-17% of institutional patients were receiving medication covertly.
      Despite legislation, incomplete documentation was common and nursing staff alone 
      often made the decision to administer medication covertly. Covert administration 
      appears to be common in older adults with dementia but despite legislation it
      often takes place without documentation and consultation of all relevant parties.
      Staff education and training and local audit are needed to improve standards and 
      safeguard vulnerable patients in institutions.
CI  - (c) 2010 Blackwell Publishing.
FAU - Haw, C
AU  - Haw C
AD  - Consultant Psychiatrist, and Research Pharmacist, St Andrew's Healthcare,
      Northampton, UK. chaw@standrew.co.uk
FAU - Stubbs, J
AU  - Stubbs J
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Psychiatr Ment Health Nurs
JT  - Journal of psychiatric and mental health nursing
JID - 9439514
RN  - 0 (Pharmaceutical Preparations)
MH  - Aged
MH  - Documentation/standards
MH  - Drug Therapy/*ethics
MH  - Guidelines as Topic
MH  - Humans
MH  - *Informed Consent
MH  - Institutionalization
MH  - Mental Competency
MH  - Pharmaceutical Preparations/*administration & dosage
EDAT- 2010/11/03 06:00
MHDA- 2011/03/05 06:00
CRDT- 2010/11/03 06:00
PHST- 2010/11/03 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/03/05 06:00 [medline]
AID - 10.1111/j.1365-2850.2010.01613.x [doi]
PST - ppublish
SO  - J Psychiatr Ment Health Nurs. 2010 Nov;17(9):761-8. doi:
      10.1111/j.1365-2850.2010.01613.x.


PMID- 21040183
OWN - NLM
STAT- MEDLINE
DCOM- 20110107
LR  - 20181201
IS  - 1753-6405 (Electronic)
IS  - 1326-0200 (Linking)
VI  - 34
IP  - 5
DP  - 2010 Oct
TI  - Fact or fallacy? Immunisation arguments in the New Zealand print media.
PG  - 521-6
LID - 10.1111/j.1753-6405.2010.00601.x [doi]
AB  - OBJECTIVE: To explore New Zealand's four major daily newspapers' coverage of
      immunisation with regards to errors of fact and fallacy in construction of
      immunisation-related arguments. METHODS: All articles from 2002 to 2007 were
      assessed for errors of fact and logic. Fact was defined as that which was
      supported by the most current evidence-based medical literature. Errors of logic 
      were assessed using a classical taxonomy broadly based in Aristotle's
      classifications. RESULTS: Numerous errors of both fact and logic were identified,
      predominantly used by anti-immunisation proponents, but occasionally by health
      authorities. The proportion of media articles reporting exclusively fact changes 
      over time during the life of a vaccine where new vaccines incur little fallacious
      reporting and established vaccines generate inaccurate claims. Fallacious
      arguments can be deconstructed and classified into a classical taxonomy including
      non sequitur and argumentum ad Hominem. CONCLUSION: Most media 'balance' given to
      immunisation relies on 'he said, she said' arguments using quotes from opposing
      spokespersons with a failure to verify the scientific validity of both the
      material and the source. IMPLICATIONS: Health professionals and media need
      training so that recognising and critiquing public health arguments becomes
      accepted practice: stronger public relations strategies should challenge poor
      quality articles to journalists' code of ethics and the health sector needs to be
      proactive in predicting and pre-empting the expected responses to introduction of
      new public health initiatives such as a new vaccine.
CI  - (c) 2010 The Authors. Journal Compilation (c) 2010 Public Health Association of
      Australia.
FAU - Petousis-Harris, Helen A
AU  - Petousis-Harris HA
AD  - Department of General Practice & Primary Health Care, The University of Auckland,
      New Zealand. h.petousis-harris@auckland.ac.nz
FAU - Goodyear-Smith, Felicity A
AU  - Goodyear-Smith FA
FAU - Kameshwar, Kamya
AU  - Kameshwar K
FAU - Turner, Nikki
AU  - Turner N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Aust N Z J Public Health
JT  - Australian and New Zealand journal of public health
JID - 9611095
SB  - IM
MH  - Bibliometrics
MH  - Humans
MH  - Immunization/*adverse effects/*statistics & numerical data
MH  - New Zealand
MH  - *Newspapers as Topic
MH  - Periodicals as Topic/standards/*statistics & numerical data
EDAT- 2010/11/03 06:00
MHDA- 2011/01/08 06:00
CRDT- 2010/11/03 06:00
PHST- 2010/11/03 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/01/08 06:00 [medline]
AID - 10.1111/j.1753-6405.2010.00601.x [doi]
PST - ppublish
SO  - Aust N Z J Public Health. 2010 Oct;34(5):521-6. doi:
      10.1111/j.1753-6405.2010.00601.x.


PMID- 21040154
OWN - NLM
STAT- MEDLINE
DCOM- 20110615
LR  - 20110215
IS  - 1460-9592 (Electronic)
IS  - 1155-5645 (Linking)
VI  - 21
IP  - 3
DP  - 2011 Mar
TI  - Designing simple PK-PD studies in children.
PG  - 190-6
LID - 10.1111/j.1460-9592.2010.03436.x [doi]
AB  - Conducting clinical pharmacology research studies in pediatric patients is
      challenging because of ethical and practical constraints but necessary to ensure 
      that drugs are used safely and effectively in this population. Developments in
      laboratory analytical techniques, such as improved assay sensitivity and the use 
      of alternative sample matrices, can reduce blood loss and offer less invasive
      blood sampling, causing less trauma to the patient and fewer ethical concerns.
      Recent advances in data analysis techniques, which aim to extract the maximum
      amount of useful information from small sample numbers, should be considered when
      planning a clinical trial and incorporated into the study design. Using
      'population' methodology allows a more flexible sampling strategy that enables
      valuable data to be collected in the course of routine clinical practice, rather 
      than in a rigid, and potentially artificial, setting. Integration of
      pharmacokinetics and pharmacodynamics and the application of physiological
      approaches and simulation techniques to the analysis and interpretation of drug
      concentration and effect data offer new opportunities that have particular
      relevance to pharmacological research in the field of pediatric anesthetics.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Thomson, Alison H
AU  - Thomson AH
AD  - Strathclyde Institute of Pharmacy and Biomedical Sciences, University of
      Strathclyde, Glasgow, UK. alison.h.thomson@strath.ac.uk
FAU - Elliott, Henry L
AU  - Elliott HL
LA  - eng
PT  - Journal Article
DEP - 20101029
PL  - France
TA  - Paediatr Anaesth
JT  - Paediatric anaesthesia
JID - 9206575
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Child
MH  - Clinical Trials as Topic/methods
MH  - Data Interpretation, Statistical
MH  - Demography
MH  - Documentation
MH  - Humans
MH  - Pediatrics
MH  - Pharmaceutical Preparations/blood
MH  - *Pharmacokinetics
MH  - *Pharmacology, Clinical
MH  - Population
MH  - *Research Design
MH  - Sample Size
EDAT- 2010/11/03 06:00
MHDA- 2011/06/16 06:00
CRDT- 2010/11/03 06:00
PHST- 2010/11/03 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/06/16 06:00 [medline]
AID - 10.1111/j.1460-9592.2010.03436.x [doi]
PST - ppublish
SO  - Paediatr Anaesth. 2011 Mar;21(3):190-6. doi: 10.1111/j.1460-9592.2010.03436.x.
      Epub 2010 Oct 29.


PMID- 21039955
OWN - NLM
STAT- MEDLINE
DCOM- 20110214
LR  - 20220318
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Linking)
VI  - 32
IP  - 7
DP  - 2010 Oct
TI  - Ethical brain stimulation - neuroethics of deep brain stimulation in research and
      clinical practice.
PG  - 1152-62
LID - 10.1111/j.1460-9568.2010.07421.x [doi]
AB  - Deep brain stimulation (DBS) is a clinically established procedure for treating
      severe motor symptoms in patients suffering from end-stage Parkinson's disease,
      dystonia and essential tremor. Currently, it is tested for further indications
      including psychiatric disorders like major depression and a variety of other
      diseases. However, ethical issues of DBS demand continuing discussion. Analysing 
      neuroethical and clinical literature, five major topics concerning the ethics of 
      DBS in clinical practice were identified: thorough examination and weighing of
      risks and benefits; selecting patients fairly; protecting the health of children 
      in paediatric DBS; special issues concerning patients' autonomy; and the
      normative impact of quality of life measurements. In exploring DBS for further
      applications, additionally, issues of research ethics have to be considered. Of
      special importance in this context are questions such as what additional value is
      generated by the research, how to realise scientific validity, which patients
      should be included, and how to achieve an acceptable risk-benefit ratio.
      Patients' benefit is central for ethical evaluation. This criterion can outweigh 
      very serious side-effects, and can make DBS appropriate even in paediatrics.
      Because standard test procedures evade central aspects of patients' benefits,
      measuring quality of life should be supplemented by open in-depth interviews to
      provide a more adequate picture of patients' post-surgical situation. To examine 
      its entire therapeutic potential, further research in DBS is needed. Studies
      should be based on solid scientific hypotheses and proceed cautiously to benefit 
      severely suffering patients without putting them to undue risks.
CI  - (c) 2010 The Author. European Journal of Neuroscience (c) 2010 Federation of
      European Neuroscience Societies and Blackwell Publishing Ltd.
FAU - Clausen, Jens
AU  - Clausen J
AD  - University of Tubingen, Institute for Ethics and History in Medicine, Gartenstr. 
      47, 72074 Tubingen, Germany. jens.clausen@uni-tuebingen.de
LA  - eng
PT  - Journal Article
PT  - Review
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
SB  - IM
MH  - Animals
MH  - Biomedical Research/ethics
MH  - Clinical Trials as Topic/*ethics/methods
MH  - *Deep Brain Stimulation/adverse effects/ethics/methods
MH  - Humans
MH  - Nervous System Diseases/psychology/*therapy
MH  - Quality of Life
EDAT- 2010/11/03 06:00
MHDA- 2011/02/15 06:00
CRDT- 2010/11/03 06:00
PHST- 2010/11/03 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/02/15 06:00 [medline]
AID - 10.1111/j.1460-9568.2010.07421.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 2010 Oct;32(7):1152-62. doi: 10.1111/j.1460-9568.2010.07421.x.


PMID- 21039890
OWN - NLM
STAT- MEDLINE
DCOM- 20110303
LR  - 20220317
IS  - 1600-0501 (Electronic)
IS  - 0905-7161 (Linking)
VI  - 21
IP  - 11
DP  - 2010 Nov
TI  - Cone beam imaging: is this the ultimate imaging modality?
PG  - 1201-8
LID - 10.1111/j.1600-0501.2010.01996.x [doi]
AB  - This review article provides an overview of cone beam (CB) imaging technology and
      its role in orofacial imaging, including comparison with two-dimensional (2D)
      radiography and multislice computed tomography (MCT). The radiation dose levels
      of CB systems are discussed, with reference to those delivered by MCT and common 
      dental 2D views. The large variation in dose levels delivered by CB systems and
      the importance of using ultra low-dose CB units are emphasized. Low-dose MCT
      protocols can be used. CB and MCT image quality are compared. CB is an essential 
      technique that all dental and orofacial clinicians must be familiar with. Where
      ultra low-dose systems and protocols are used, CB imaging should be considered in
      day-to-day clinical practice. However, CB imaging is not the technique of choice 
      in many clinical scenarios. Rather than replacing other modalities, CB imaging
      complements intraoral 2D radiography, panoramic radiography, MCT and other
      techniques including magnetic resonance imaging, ultrasound and nuclear medicine.
      MCT is a much more powerful and flexible modality and presently remains the
      technique of choice over CB imaging in many clinical scenarios. All radiologic
      examinations, including CB and MCT, should be comprehensively evaluated in
      entirety. The responsibilities and the radiological skill levels of clinicians
      involved in imaging as well as the associated ethical and medico-legal
      implications require consideration.
CI  - (c) 2010 John Wiley & Sons A/S.
FAU - Koong, Bernard
AU  - Koong B
AD  - School of Dentistry, University of Western Australia, Nedlands, WA, Australia.
      bkoong@iinet.net.au
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Denmark
TA  - Clin Oral Implants Res
JT  - Clinical oral implants research
JID - 9105713
MH  - *Cone-Beam Computed Tomography
MH  - Humans
MH  - Radiation Dosage
MH  - Radiographic Image Interpretation, Computer-Assisted
MH  - Stomatognathic Diseases/*diagnostic imaging
EDAT- 2010/11/03 06:00
MHDA- 2011/03/04 06:00
CRDT- 2010/11/03 06:00
PHST- 2010/11/03 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/03/04 06:00 [medline]
AID - 10.1111/j.1600-0501.2010.01996.x [doi]
PST - ppublish
SO  - Clin Oral Implants Res. 2010 Nov;21(11):1201-8. doi:
      10.1111/j.1600-0501.2010.01996.x.


PMID- 21039886
OWN - NLM
STAT- MEDLINE
DCOM- 20120112
LR  - 20120314
IS  - 1399-0012 (Electronic)
IS  - 0902-0063 (Linking)
VI  - 25
IP  - 4
DP  - 2011 Jul-Aug
TI  - Transplant tourism--a dangerous journey?
PG  - 633-7
LID - 10.1111/j.1399-0012.2010.01325.x [doi]
AB  - INTRODUCTION: While the ethical aspects of transplant tourism have received much 
      attention recently, less has been written about the medical safety of this
      practice. We retrospectively evaluated the outcomes of patients who purchased
      organs internationally and presented to our center for follow-up care. METHODS:
      Baseline demographic characteristics were recorded. Post-operative outcomes
      including patient survival, graft survival, five-yr graft function, and
      complications were assessed. RESULTS: Eight patients who purchased international 
      organs for transplant were identified. The country of transplant was China (n =
      3), Pakistan (n = 3), India (n = 1), and the Philippines (n = 1). All patients
      were born in either Asia or the Middle East and traveled to the region of their
      ethnicity for transplantation. The mean time to presentation was 49 d
      post-operatively. The overall one- and two-yr patient survival rates were 87% and
      75%, respectively. One patient died of miliary tuberculosis and another of
      Acinetobacter baumanii sepsis. There was one case of newly acquired hepatitis B
      infection. At last follow-up, all six surviving patients had functioning grafts
      with a mean creatinine level of 1.26 mg/dL at five yr. CONCLUSION: Although
      intermediate-term graft function is acceptable, the early morbidity and mortality
      among transplant tourists is high. These results suggest that the associated
      risks may not justify the trip.
CI  - (c) 2010 John Wiley & Sons A/S.
FAU - Polcari, Anthony J
AU  - Polcari AJ
AD  - Department of Urology, Loyola University Stritch School of Medicine, Maywood, IL,
      USA. apolcar@lumc.edu
FAU - Hugen, Cory M
AU  - Hugen CM
FAU - Farooq, Ahmer V
AU  - Farooq AV
FAU - Holt, David R
AU  - Holt DR
FAU - Hou, Susan H
AU  - Hou SH
FAU - Milner, John E
AU  - Milner JE
LA  - eng
PT  - Journal Article
DEP - 20101011
PL  - Denmark
TA  - Clin Transplant
JT  - Clinical transplantation
JID - 8710240
SB  - IM
MH  - China
MH  - Cytomegalovirus/pathogenicity
MH  - Cytomegalovirus Infections/complications/virology
MH  - Female
MH  - Follow-Up Studies
MH  - Graft Rejection/*etiology/mortality
MH  - Graft Survival
MH  - Hepacivirus/pathogenicity
MH  - Hepatitis C/complications/virology
MH  - Humans
MH  - India
MH  - Kidney Transplantation/adverse effects/*mortality/*statistics & numerical data
MH  - Male
MH  - Medical Tourism/*statistics & numerical data
MH  - Middle Aged
MH  - Middle East
MH  - Pakistan
MH  - Philippines
MH  - Retrospective Studies
MH  - Survival Rate
MH  - Tissue Donors
MH  - Treatment Outcome
EDAT- 2010/11/03 06:00
MHDA- 2012/01/13 06:00
CRDT- 2010/11/03 06:00
PHST- 2010/11/03 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2012/01/13 06:00 [medline]
AID - 10.1111/j.1399-0012.2010.01325.x [doi]
PST - ppublish
SO  - Clin Transplant. 2011 Jul-Aug;25(4):633-7. doi: 10.1111/j.1399-0012.2010.01325.x.
      Epub 2010 Oct 11.


PMID- 21039694
OWN - NLM
STAT- MEDLINE
DCOM- 20120820
LR  - 20181201
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 26
IP  - 4
DP  - 2012 May
TI  - An undignified bioethics: there is no method in this madness.
PG  - 224-30
LID - 10.1111/j.1467-8519.2010.01849.x [doi]
AB  - In a recent article, Alasdair Cochrane argues for the need to have an undignified
      bioethics. His is not, of course, a call to transform bioethics into an
      inelegant, pathetic discipline, or one failing to meet appropriate disciplinary
      standards. His is a call to simply eliminate the concept of human dignity from
      bioethical discourse. Here I argue that he fails to make his case. I first show
      that several of the flaws that Cochrane identifies are not flaws of the
      conceptions of dignity he discusses but rather flaws of his, often problematic,
      understanding of such conceptions. Second, I argue that Cochrane's case against
      the concept of human dignity goes too far. I thus show that were one to agree
      that these are indeed flaws that require that we discard our ethical concepts,
      then following Cochrane's recommendations would commit us not only to an
      undignified bioethics, i.e. a bioethics without dignity, but to a bioethics
      without much ethics at all.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - De Melo-Martin, Inmaculada
AU  - De Melo-Martin I
AD  - Division of Medical Ethics, Department of Public Health, Weill Cornell Medical
      College, 402 E. 67th St., New York, NY 10065, USA. imd2001@med.cornell.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Comment
DEP - 20101006
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
CON - Bioethics. 2010 Jun;24(5):234-41. PMID: 20002071
MH  - Bioethics/*trends
MH  - *Human Rights
MH  - Humans
MH  - *Moral Obligations
MH  - *Personal Autonomy
MH  - *Personhood
EDAT- 2010/11/03 06:00
MHDA- 2012/08/21 06:00
CRDT- 2010/11/03 06:00
PHST- 2010/11/03 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2012/08/21 06:00 [medline]
AID - 10.1111/j.1467-8519.2010.01849.x [doi]
PST - ppublish
SO  - Bioethics. 2012 May;26(4):224-30. doi: 10.1111/j.1467-8519.2010.01849.x. Epub
      2010 Oct 6.


PMID- 21039693
OWN - NLM
STAT- MEDLINE
DCOM- 20120820
LR  - 20120410
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 26
IP  - 4
DP  - 2012 May
TI  - Orphaned at conception: the uncanny offspring of embryos.
PG  - 173-81
LID - 10.1111/j.1467-8519.2010.01848.x [doi]
AB  - A number of advances in assisted reproduction have been greeted by the accusation
      that they would produce children 'without parents'. In this paper I will argue
      that while to date these accusations have been false, there is a limited but
      important sense in which they would be true of children born of a reproductive
      technology that is now on the horizon. If our genetic parents are those
      individuals from whom we have inherited 50% of our genes, then, unlike in any
      other reproductive scenario, children who were conceived from gametes derived
      from stem cell lines derived from discarded IVF embryos would have no genetic
      parents! This paper defends this claim and investigates its ethical implications.
      I argue that there are reasons to think that the creation of such embryos might
      be morally superior to the existing alternatives in an important set of
      circumstances.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Sparrow, Robert
AU  - Sparrow R
AD  - Centre for Human Bioethics, Clayton, Victoria, Australia.
      robert.sparrow@arts.monash.edu.au
LA  - eng
PT  - Journal Article
DEP - 20101006
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Cell Line
MH  - *Child, Orphaned
MH  - Cloning, Organism/ethics
MH  - *Embryonic Stem Cells
MH  - Fertilization in Vitro/ethics
MH  - *Germ Cells
MH  - Humans
MH  - *Parent-Child Relations
MH  - Reproductive Techniques, Assisted/*ethics
EDAT- 2010/11/03 06:00
MHDA- 2012/08/21 06:00
CRDT- 2010/11/03 06:00
PHST- 2010/11/03 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2012/08/21 06:00 [medline]
AID - 10.1111/j.1467-8519.2010.01848.x [doi]
PST - ppublish
SO  - Bioethics. 2012 May;26(4):173-81. doi: 10.1111/j.1467-8519.2010.01848.x. Epub
      2010 Oct 6.


PMID- 21039690
OWN - NLM
STAT- MEDLINE
DCOM- 20120820
LR  - 20120410
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 26
IP  - 4
DP  - 2012 May
TI  - Symbiotic empirical ethics: a practical methodology.
PG  - 198-206
LID - 10.1111/j.1467-8519.2010.01843.x [doi]
AB  - Like any discipline, bioethics is a developing field of academic inquiry; and
      recent trends in scholarship have been towards more engagement with empirical
      research. This 'empirical turn' has provoked extensive debate over how such
      'descriptive' research carried out in the social sciences contributes to the
      distinctively normative aspect of bioethics. This paper will address this issue
      by developing a practical research methodology for the inclusion of data from
      social science studies into ethical deliberation. This methodology will be based 
      on a naturalistic conception of ethical theory that sees practice as informing
      theory just as theory informs practice - the two are symbiotically related. From 
      this engagement with practice, the ways that such theories need to be extended
      and developed can be determined. This is a practical methodology for integrating 
      theory and practice that can be used in empirical studies, one that uses ethical 
      theory both to explore the data and to draw normative conclusions.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Frith, Lucy
AU  - Frith L
AD  - University of Liverpool - Institute of Psychology, Health and Society, The
      Waterhouse Buildings, Brownlow Hill, Liverpool L69 3GL, United Kingdom.
      l.j.frith@liverpool.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20101006
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - *Bioethics
MH  - *Empirical Research
MH  - Ethical Analysis/*methods
MH  - *Ethical Theory
MH  - Humans
MH  - *Social Sciences
EDAT- 2010/11/03 06:00
MHDA- 2012/08/21 06:00
CRDT- 2010/11/03 06:00
PHST- 2010/11/03 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2012/08/21 06:00 [medline]
AID - 10.1111/j.1467-8519.2010.01843.x [doi]
PST - ppublish
SO  - Bioethics. 2012 May;26(4):198-206. doi: 10.1111/j.1467-8519.2010.01843.x. Epub
      2010 Oct 6.


PMID- 21039689
OWN - NLM
STAT- MEDLINE
DCOM- 20120820
LR  - 20120410
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 26
IP  - 4
DP  - 2012 May
TI  - On Taylor's justification of medical informed consent.
PG  - 207-14
LID - 10.1111/j.1467-8519.2010.01842.x [doi]
AB  - In contemporary Western biomedical ethics, informed consent practices are
      commonly justified in terms of the intrinsic value of patient autonomy. James
      Stacey Taylor maintains that this conception of the moral grounding of medical
      informed consent is mistaken. On the basis of his reasoning to that effect,
      Taylor argues that medical informed consent is justified by the instrumental
      value of personal autonomy. In this article, I examine whether Taylor's
      justification of medical informed consent is plausible.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Varelius, Jukka
AU  - Varelius J
AD  - Department of Behavioural Sciences and Philosophy, FIN-20014 University of Turku,
      Finland. jukka.varelius@utu.fi
LA  - eng
PT  - Biography
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101006
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Ethical Analysis
MH  - History, 21st Century
MH  - Humans
MH  - Informed Consent/*ethics
MH  - *Personal Autonomy
MH  - Professional-Patient Relations/*ethics
PS  - Taylor JS
FPS - Taylor, James Stacey
EDAT- 2010/11/03 06:00
MHDA- 2012/08/21 06:00
CRDT- 2010/11/03 06:00
PHST- 2010/11/03 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2012/08/21 06:00 [medline]
AID - 10.1111/j.1467-8519.2010.01842.x [doi]
PST - ppublish
SO  - Bioethics. 2012 May;26(4):207-14. doi: 10.1111/j.1467-8519.2010.01842.x. Epub
      2010 Oct 6.


PMID- 21039687
OWN - NLM
STAT- MEDLINE
DCOM- 20120711
LR  - 20120203
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 26
IP  - 3
DP  - 2012 Mar
TI  - Developments in stem cell research and therapeutic cloning: Islamic ethical
      positions, a review.
PG  - 128-35
LID - 10.1111/j.1467-8519.2010.01840.x [doi]
AB  - Stem cell research is very promising. The use of human embryos has been
      confronted with objections based on ethical and religious positions. The recent
      production of reprogrammed adult (induced pluripotent) cells does not - in the
      opinion of scientists - reduce the need to continue human embryonic stem cell
      research. So the debate continues. Islam always encouraged scientific research,
      particularly research directed toward finding cures for human disease. Based on
      the expectation of potential benefits, Islamic teachings permit and support human
      embryonic stem cell research. The majority of Muslim scholars also support
      therapeutic cloning. This permissibility is conditional on the use of
      supernumerary early pre-embryos which are obtained during infertility treatment
      in vitro fertilization (IVF) clinics. The early pre-embryos are considered in
      Islamic jurisprudence as worthy of respect but do not have the full sanctity
      offered to the embryo after implantation in the uterus and especially after
      ensoulment. In this paper the Islamic positions regarding human embryonic stem
      cell research and therapeutic cloning are reviewed in some detail, whereas
      positions in other religious traditions are mentioned only briefly. The status of
      human embryonic stem cell research and therapeutic cloning in different
      countries, including the USA and especially in Muslim countries, is discussed.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Fadel, Hossam E
AU  - Fadel HE
AD  - Medical College of Georgia, Department of Obstetrics and Gynecology, Augusta,
      USA. hefadel@gmail.com
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20101006
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Cloning, Organism/*ethics
MH  - *Embryonic Stem Cells
MH  - Humans
MH  - *Islam
MH  - Personhood
MH  - *Religion and Science
MH  - Stem Cell Research/*ethics
EDAT- 2010/11/03 06:00
MHDA- 2012/07/12 06:00
CRDT- 2010/11/03 06:00
PHST- 2010/11/03 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2012/07/12 06:00 [medline]
AID - 10.1111/j.1467-8519.2010.01840.x [doi]
PST - ppublish
SO  - Bioethics. 2012 Mar;26(3):128-35. doi: 10.1111/j.1467-8519.2010.01840.x. Epub
      2010 Oct 6.


PMID- 21039686
OWN - NLM
STAT- MEDLINE
DCOM- 20120711
LR  - 20120203
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 26
IP  - 3
DP  - 2012 Mar
TI  - The ethics of managing affective and emotional states to improve informed
      consent: autonomy, comprehension, and voluntariness.
PG  - 149-56
LID - 10.1111/j.1467-8519.2010.01838.x [doi]
AB  - Over the past several decades the 'affective revolution' in cognitive psychology 
      has emphasized the critical role affect and emotion play in human
      decision-making. Drawing on this affective literature, various commentators have 
      recently proposed strategies for managing therapeutic expectation that use
      contextual, symbolic, or emotive interventions in the consent process to convey
      information or enhance comprehension. In this paper, we examine whether affective
      consent interventions that target affect and emotion can be reconciled with
      widely accepted standards for autonomous action. More specifically, the ethics of
      affective consent interventions is assessed in terms of key elements of autonomy,
      comprehension and voluntariness. While there may appear to be a moral obligation 
      to manage the affective environment to ensure valid informed consent, in
      circumstances where volunteers may be prone to problematic therapeutic
      expectancy, this moral obligation needs to be weighed against the potential risks
      of human instrumentalization. At this point in time we do not have enough
      information to be able to justify clearly the programmatic manipulation of human 
      subjects' affective states. The lack of knowledge about affective interventions
      requires corresponding caution in its ethical justification.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Braude, Hillel
AU  - Braude H
AD  - Biomedical Ethics Unit, Faculty of Medicine, McGill University, Montreal, Quebec,
      Canada. hillel.braude@mail.mcgill.ca
FAU - Kimmelman, Jonathan
AU  - Kimmelman J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101006
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - *Affect
MH  - *Comprehension
MH  - *Emotions
MH  - Humans
MH  - Informed Consent/*ethics
MH  - *Personal Autonomy
EDAT- 2010/11/03 06:00
MHDA- 2012/07/12 06:00
CRDT- 2010/11/03 06:00
PHST- 2010/11/03 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2012/07/12 06:00 [medline]
AID - 10.1111/j.1467-8519.2010.01838.x [doi]
PST - ppublish
SO  - Bioethics. 2012 Mar;26(3):149-56. doi: 10.1111/j.1467-8519.2010.01838.x. Epub
      2010 Oct 6.


PMID- 21039031
OWN - NLM
STAT- MEDLINE
DCOM- 20110329
LR  - 20220318
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Linking)
VI  - 11
IP  - 3
DP  - 2010
TI  - Breast self-examination: knowledge and practice among nurses in United Arab
      Emirates.
PG  - 651-4
AB  - This study was conducted to explore the knowledge and practice of nurses
      regarding breast self-examination (BSE) in the United Arab Emirates. Nurses
      working in different hospitals constituted the study population. A total of 154
      nurses who had come to participate in the breast cancer awareness week programme 
      were the participants. Approval of the Gulf Medical University ethics committee
      was obtained. A self-administered, pre-tested, structured, close ended
      questionnaire was used for data collection. Statistical analysis was performed
      using PASW 17. Age of the participants in this study ranged from 20 to 59 years, 
      with a mean age of 24.1 years. 96.1% of the participants were aware of the ideal 
      age to start BSE, while 87.7% respondents knew that women with regular
      menstruation should perform BSE monthly on a particular day, preferably on the
      fifth or seventh day after menstruation. With regard to BSE technique, 68.8% knew
      that both inspection and palpation were the ideal methods to detect any change in
      the breast. A high proportion, 84.4% of the respondents, reported performing BSE.
      Among those married, 87.0% and among single 78.3% were practicing BSE. The
      results point out that the nurses have a satisfactory knowledge regarding BSE and
      this is shown in their practice of BSE. Emphasis should be laid on BSE in
      undergraduate and postgraduate courses, especially for nurses, as they are mostly
      involved in patient care and education.
FAU - Sreedharan, Jayadevan
AU  - Sreedharan J
AD  - Gulf Medical University, Ajman, UAE. drjayadevans@gmail.com
FAU - Muttappallymyalil, Jayakumary
AU  - Muttappallymyalil J
FAU - Venkatramana, Manda
AU  - Venkatramana M
FAU - Thomas, Merlin
AU  - Thomas M
LA  - eng
PT  - Journal Article
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
SB  - IM
MH  - Adult
MH  - Breast Neoplasms/*diagnosis/prevention & control
MH  - Breast Self-Examination/*nursing/*statistics & numerical data
MH  - Cross-Sectional Studies
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Middle Aged
MH  - Nurses/*statistics & numerical data
MH  - Patient Education as Topic
MH  - Prognosis
MH  - United Arab Emirates
MH  - Young Adult
EDAT- 2010/11/03 06:00
MHDA- 2011/03/30 06:00
CRDT- 2010/11/03 06:00
PHST- 2010/11/03 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/03/30 06:00 [medline]
PST - ppublish
SO  - Asian Pac J Cancer Prev. 2010;11(3):651-4.


PMID- 21038999
OWN - NLM
STAT- MEDLINE
DCOM- 20110217
LR  - 20130515
IS  - 1735-3947 (Electronic)
IS  - 1029-2977 (Linking)
VI  - 13
IP  - 6
DP  - 2010 Nov
TI  - Editorial independence and ethics of research publication.
PG  - 465-8
LID - 010136/AIM.003 [doi]
FAU - Etemadi, Arash
AU  - Etemadi A
FAU - Golozar, Asieh
AU  - Golozar A
FAU - Malekzadeh, Reza
AU  - Malekzadeh R
LA  - eng
PT  - Editorial
PL  - Iran
TA  - Arch Iran Med
JT  - Archives of Iranian medicine
JID - 100889644
SB  - IM
MH  - Biomedical Research
MH  - Editorial Policies
MH  - *Ethics, Research
MH  - Humans
MH  - Iran
MH  - Periodicals as Topic/*ethics
MH  - Publishing/*ethics
EDAT- 2010/11/03 06:00
MHDA- 2011/02/18 06:00
CRDT- 2010/11/03 06:00
PHST- 2010/11/03 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/02/18 06:00 [medline]
AID - 003 [pii]
AID - 010136/AIM.003 [doi]
PST - ppublish
SO  - Arch Iran Med. 2010 Nov;13(6):465-8. doi: 010136/AIM.003.


PMID- 21037881
OWN - NLM
STAT- MEDLINE
DCOM- 20101115
LR  - 20211020
IS  - 0008-5286 (Print)
IS  - 0008-5286 (Linking)
VI  - 51
IP  - 8
DP  - 2010 Aug
TI  - Veterinary medical ethics. An ethicist's commentary on the majority treating
      agriculture unfairly.
PG  - 808-9
FAU - Rollin, Bernard E
AU  - Rollin BE
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Vet J
JT  - The Canadian veterinary journal = La revue veterinaire canadienne
JID - 0004653
SB  - IM
MH  - Agriculture/ethics
MH  - Animal Husbandry/*ethics
MH  - *Animal Welfare
MH  - Animals
MH  - Canada
MH  - Food Supply/*ethics/*standards
MH  - Humans
MH  - Veterinary Medicine/*ethics
PMC - PMC2904998
EDAT- 2010/11/03 06:00
MHDA- 2010/11/16 06:00
CRDT- 2010/11/02 06:00
PHST- 2010/11/02 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2010/11/16 06:00 [medline]
PST - ppublish
SO  - Can Vet J. 2010 Aug;51(8):808-9.


PMID- 21037875
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1935-469X (Electronic)
IS  - 1554-7477 (Linking)
VI  - 6
IP  - 4
DP  - 2010 Jul
TI  - Issues surrounding biospecimen collection and use in clinical trials.
PG  - 206-9
LID - 10.1200/JOP.777004 [doi]
AB  - As the need for patient participation in biospecimen and correlative research
      increases, challenging ethical and potentially legal questions are emerging.
FAU - Baer, Allison R
AU  - Baer AR
AD  - American Society of Clinical Oncology, Alexandria, VA; Research Advocacy Network,
      Plano, TX; Patient Advocates in Research, Danville, CA; and Duke University
      Medical Center, Chapel Hill, NC.
FAU - Smith, Mary Lou
AU  - Smith ML
FAU - Collyar, Deborah
AU  - Collyar D
FAU - Peppercorn, Jeffrey
AU  - Peppercorn J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Oncol Pract
JT  - Journal of oncology practice
JID - 101261852
PMC - PMC2900874
EDAT- 2010/11/03 06:00
MHDA- 2010/11/03 06:01
CRDT- 2010/11/02 06:00
PHST- 2010/05/19 00:00 [accepted]
PHST- 2010/11/02 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2010/11/03 06:01 [medline]
AID - 10.1200/JOP.777004 [doi]
PST - ppublish
SO  - J Oncol Pract. 2010 Jul;6(4):206-9. doi: 10.1200/JOP.777004.


PMID- 21037414
OWN - NLM
STAT- MEDLINE
DCOM- 20110210
LR  - 20111117
IS  - 1529-8795 (Electronic)
IS  - 0031-5982 (Linking)
VI  - 53
IP  - 4
DP  - 2010 Autumn
TI  - Does pediatrics need its own bioethics?
PG  - 613-24
LID - 10.1353/pbm.2010.0011 [doi]
AB  - Pediatric bioethics raises unique issues because children are constantly growing,
      developing, and changing. The ethical issues that arise for newborns are
      different from those that arise for seven-year-olds or 17-year-olds. Furthermore,
      children do not develop cognitive capacities or moral reasoning skills at the
      same rate. Thus, it is difficult to generalize about what is appropriate or
      inappropriate for children in either the clinical or the research setting. This
      article responds to some of the issues raised by a new volume of essays about
      pediatric bioethics. It puts these issues into historical context by examining
      the implications of Saul Krugman's famous studies on the etiology and prevention 
      of hepatitis at New York's Willowbrook State School.
FAU - Lantos, John D
AU  - Lantos JD
AD  - University of Missouri at Kansas City, Children's Mercy Bioethics Center,
      Children's Mercy Hospital, Kansas City, MO 64108, USA. jlantos@cmh.edu
LA  - eng
PT  - Biography
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - Perspect Biol Med
JT  - Perspectives in biology and medicine
JID - 0401132
SB  - IM
MH  - *Bioethical Issues
MH  - Child
MH  - *Child, Institutionalized
MH  - Ethics, Research/history
MH  - Hepatitis, Viral, Human/*history
MH  - History, 20th Century
MH  - Humans
MH  - Intellectual Disability
MH  - New York
MH  - Nontherapeutic Human Experimentation/*ethics/history
MH  - Pediatrics/*ethics
PS  - Krugman S
FPS - Krugman, Saul
EDAT- 2010/11/03 06:00
MHDA- 2011/02/11 06:00
CRDT- 2010/11/02 06:00
PHST- 2010/11/02 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/02/11 06:00 [medline]
AID - S1529879510400113 [pii]
AID - 10.1353/pbm.2010.0011 [doi]
PST - ppublish
SO  - Perspect Biol Med. 2010 Autumn;53(4):613-24. doi: 10.1353/pbm.2010.0011.


PMID- 21037407
OWN - NLM
STAT- MEDLINE
DCOM- 20110210
LR  - 20101101
IS  - 1529-8795 (Electronic)
IS  - 0031-5982 (Linking)
VI  - 53
IP  - 4
DP  - 2010 Autumn
TI  - Financial conflicts of interest and the ethical obligations of medical school
      faculty and the profession.
PG  - 534-44
LID - 10.1353/pbm.2010.0010 [doi]
AB  - Despite their potential benefits, relationships linking medical school faculty
      and the pharmaceutical and device industries may also challenge the professional 
      value of primacy of patient welfare, a point highlighted in a recent Institute of
      Medicine report. Academic medical centers and professors have the added
      professional obligation to ensure the unbiased, evidence-based education of
      future doctors. This essay argues that faculty financial conflicts of interest
      may threaten this obligation by propagating the bias introduced by these
      relationships to students. This could occur directly through the process of
      curriculum determination and delivery, and also indirectly through the "hidden
      curriculum," which deserves particular attention, as its lessons may conflict
      with those professed in the formal curriculum. The essay concludes with guiding
      principles to consider when developing a conflict of interest policy at academic 
      medical centers.
FAU - Austad, Kirsten
AU  - Austad K
AD  - Harvard Medical School, USA.
FAU - Brendel, David H
AU  - Brendel DH
FAU - Brendel, Rebecca W
AU  - Brendel RW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Perspect Biol Med
JT  - Perspectives in biology and medicine
JID - 0401132
SB  - IM
MH  - Academic Medical Centers/*ethics
MH  - *Conflict of Interest
MH  - Curriculum
MH  - Drug Industry/*ethics
MH  - Education, Medical/ethics
MH  - *Ethics
MH  - *Faculty, Medical
MH  - Humans
MH  - Teaching/ethics
EDAT- 2010/11/03 06:00
MHDA- 2011/02/11 06:00
CRDT- 2010/11/02 06:00
PHST- 2010/11/02 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/02/11 06:00 [medline]
AID - S1529879510400046 [pii]
AID - 10.1353/pbm.2010.0010 [doi]
PST - ppublish
SO  - Perspect Biol Med. 2010 Autumn;53(4):534-44. doi: 10.1353/pbm.2010.0010.


PMID- 21037406
OWN - NLM
STAT- MEDLINE
DCOM- 20110210
LR  - 20211203
IS  - 1529-8795 (Electronic)
IS  - 0031-5982 (Linking)
VI  - 53
IP  - 4
DP  - 2010 Autumn
TI  - Ethical issues in translational research.
PG  - 517-33
LID - 10.1353/pbm.2010.0007 [doi]
AB  - The translation of biomedical research knowledge to effective clinical treatment 
      is essential to the public good and is a main focus of current health policy.
      However, recent health policy initiatives intended to foster the translation of
      basic science into clinical and public health advances must also consider the
      unique bioethical issues raised by the increased focus on translational research.
      Safety of study participants and balancing of risk due to treatment with the
      potential benefits of the research is tantamount. This article synthesizes theory
      from clinical ethics, operational design, and philosophy to provide a bioethical 
      framework for the health policy of translational research.
FAU - Petrini, Carlo
AU  - Petrini C
AD  - Bioethics Unit, Office of the President, Istituto Superiore di Sanita (National
      Institute of Health), Via Giano della Bella 34, Roma, Italy. carlo.petrini@iss.it
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Perspect Biol Med
JT  - Perspectives in biology and medicine
JID - 0401132
SB  - IM
MH  - Bioethical Issues
MH  - Europe
MH  - *Health Policy
MH  - Humans
MH  - Public Health/ethics
MH  - Translational Research, Biomedical/*ethics
MH  - United States
EDAT- 2010/11/03 06:00
MHDA- 2011/02/11 06:00
CRDT- 2010/11/02 06:00
PHST- 2010/11/02 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/02/11 06:00 [medline]
AID - S1529879510400034 [pii]
AID - 10.1353/pbm.2010.0007 [doi]
PST - ppublish
SO  - Perspect Biol Med. 2010 Autumn;53(4):517-33. doi: 10.1353/pbm.2010.0007.


PMID- 21037267
OWN - NLM
STAT- MEDLINE
DCOM- 20110118
LR  - 20220410
IS  - 1471-6771 (Electronic)
IS  - 0007-0912 (Linking)
VI  - 106
IP  - 1
DP  - 2011 Jan
TI  - Comparison of three cuffed emergency percutaneous cricothyroidotomy devices to
      conventional surgical cricothyroidotomy in a porcine model.
PG  - 57-64
LID - 10.1093/bja/aeq294 [doi]
AB  - BACKGROUND: Emergency cricothyroidotomy is a potentially life-saving procedure in
      the 'cannot intubate cannot ventilate (CICV)' scenario. Although surgical
      cricothyroidotomy remains the technique recommended in many 'CICV' algorithms,
      the insertion of a tracheostomy as a cannula over a trocar, or using the
      Seldinger method, may have advantages as they are more familiar to the
      anaesthetist. We compared the utility of three cuffed cricothyroidotomy devices: 
      cuffed Melker(R), Quicktrach 2(R), and PCK(R) devices, with surgical
      cricothyroidotomy. METHODS: After ethical committee approval and written informed
      consent, 20 anaesthetists performed cricothyroidotomy with all four devices in
      random order, in a pig larynx and trachea model covered in cured pelt. The
      primary endpoints were the rate of successful placement of the cricothyroidotomy 
      device into the trachea and the duration of the insertion attempt. RESULTS: The
      Melker(R) and Quicktrach 2(R) devices possessed advantages over the surgical
      approach, in contrast to the PCK(R) device, which performed less well. All 20
      participants inserted the Melker(R), with 19 being successful using the surgical 
      approach and the Quicktrach 2(R), whereas only 12 successfully inserted the
      PCK(R) device (PCK(R) vs surgical, P=0.02). The Quicktrach 2(R) had the fastest
      insertion times and caused least trauma to the posterior tracheal wall. The
      Melker(R) was rated highest by the participants and was the only device rated
      higher than the surgical technique. CONCLUSIONS: The Melker(R) and Quicktrach
      2(R) devices appear to hold particular promise as alternatives to surgical
      cricothyroidotomy. Further studies, in more clinically relevant models, are
      required to confirm these initial positive findings.
FAU - Murphy, C
AU  - Murphy C
AD  - Department of Anaesthesia, Galway University Hospitals, Galway, Ireland.
FAU - Rooney, S J
AU  - Rooney SJ
FAU - Maharaj, C H
AU  - Maharaj CH
FAU - Laffey, J G
AU  - Laffey JG
FAU - Harte, B H
AU  - Harte BH
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101030
PL  - England
TA  - Br J Anaesth
JT  - British journal of anaesthesia
JID - 0372541
SB  - IM
MH  - Animals
MH  - Cricoid Cartilage/*surgery
MH  - Emergencies
MH  - Equipment Design
MH  - Models, Animal
MH  - Respiration, Artificial/instrumentation/methods
MH  - Sus scrofa
MH  - Thyroid Cartilage/*surgery
MH  - Tracheostomy/adverse effects/*instrumentation/methods
EDAT- 2010/11/03 06:00
MHDA- 2011/01/19 06:00
CRDT- 2010/11/02 06:00
PHST- 2010/11/02 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/01/19 06:00 [medline]
AID - S0007-0912(17)33362-7 [pii]
AID - 10.1093/bja/aeq294 [doi]
PST - ppublish
SO  - Br J Anaesth. 2011 Jan;106(1):57-64. doi: 10.1093/bja/aeq294. Epub 2010 Oct 30.


PMID- 21037237
OWN - NLM
STAT- MEDLINE
DCOM- 20110225
LR  - 20101101
IS  - 1469-0756 (Electronic)
IS  - 0032-5473 (Linking)
VI  - 86
IP  - 1021
DP  - 2010 Nov
TI  - Ethical dilemmas: a focus of discussion for junior doctors.
PG  - 631
LID - 10.1136/pgmj.2010.110239 [doi]
FAU - Levy, Jeremy
AU  - Levy J
AD  - Imperial College Healthcare NHS Trust, London, W12 0HS, UK. j.levy@imperial.ac.uk
FAU - Coward, Bob
AU  - Coward B
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - England
TA  - Postgrad Med J
JT  - Postgraduate medical journal
JID - 0234135
SB  - IM
CON - Postgrad Med J. 2010 Nov;86(1021):632-5. PMID: 20729222
CIN - Postgrad Med J. 2010 Nov;86(1021):629-30. PMID: 21037236
MH  - *Education, Medical, Graduate
MH  - Ethics, Medical/*education
MH  - Medical Staff, Hospital/*education
MH  - Teaching
EDAT- 2010/11/03 06:00
MHDA- 2011/02/26 06:00
CRDT- 2010/11/02 06:00
PHST- 2010/11/02 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/02/26 06:00 [medline]
AID - 86/1021/631 [pii]
AID - 10.1136/pgmj.2010.110239 [doi]
PST - ppublish
SO  - Postgrad Med J. 2010 Nov;86(1021):631. doi: 10.1136/pgmj.2010.110239.


PMID- 21037236
OWN - NLM
STAT- MEDLINE
DCOM- 20110225
LR  - 20101101
IS  - 1469-0756 (Electronic)
IS  - 0032-5473 (Linking)
VI  - 86
IP  - 1021
DP  - 2010 Nov
TI  - Ethics, law, and the junior doctor.
PG  - 629-30
LID - 10.1136/pgmj.2009.092635 [doi]
FAU - Sokol, Daniel
AU  - Sokol D
FAU - Doyal, Len
AU  - Doyal L
FAU - Doyal, Lesley
AU  - Doyal L
LA  - eng
PT  - Comment
PT  - Editorial
PL  - England
TA  - Postgrad Med J
JT  - Postgraduate medical journal
JID - 0234135
SB  - IM
CON - Postgrad Med J. 2010 Nov;86(1021):632-5. PMID: 20729222
CON - Postgrad Med J. 2010 Nov;86(1021):631. PMID: 21037237
MH  - Education, Medical, Graduate
MH  - Ethics, Medical/*education
MH  - Medical Staff, Hospital/*education/ethics/legislation & jurisprudence
MH  - Teaching
EDAT- 2010/11/03 06:00
MHDA- 2011/02/26 06:00
CRDT- 2010/11/02 06:00
PHST- 2010/11/02 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/02/26 06:00 [medline]
AID - 86/1021/629 [pii]
AID - 10.1136/pgmj.2009.092635 [doi]
PST - ppublish
SO  - Postgrad Med J. 2010 Nov;86(1021):629-30. doi: 10.1136/pgmj.2009.092635.


PMID- 21037019
OWN - NLM
STAT- MEDLINE
DCOM- 20110617
LR  - 20211020
IS  - 1535-4970 (Electronic)
IS  - 1073-449X (Linking)
VI  - 183
IP  - 7
DP  - 2011 Apr 1
TI  - An empirical study of surrogates' preferred level of control over value-laden
      life support decisions in intensive care units.
PG  - 915-21
LID - 10.1164/rccm.201008-1214OC [doi]
AB  - RATIONALE: Despite ongoing ethical debate concerning who should control decisions
      to discontinue life support for incapacitated, critically ill patients, the
      perspectives of surrogate decision makers are poorly understood. OBJECTIVES: To
      determine (1) what degree of decisional authority surrogates prefer for
      value-sensitive life support decisions compared with more technical biomedical
      decisions, and (2) what predicts surrogates' preferences for more control over
      life support decisions. METHODS: This was a prospective study of 230 surrogate
      decision makers for incapacitated, mechanically ventilated patients at high risk 
      of death. Surrogates reported their preferred degree of decisional authority
      using the Degner Control Preferences Scale for two types of decisions: a
      value-sensitive decision about whether to discontinue life support and a decision
      regarding which antibiotic to prescribe for an infection. MEASUREMENTS AND MAIN
      RESULTS: The majority of surrogates (55%, 127/230; 95% confidence interval,
      49-62%) preferred to have final control over the value-sensitive life support
      decision; 40% (91/230) wished to share control equally with the physician; 5%
      (12/230) of surrogates wanted the physician to make the decision. Surrogates
      preferred significantly more control over the value-sensitive life support
      decision compared with the technical decision about choice of antibiotics (P <
      0.0001). Factors independently associated with surrogates' preference for more
      control over the life support decision were: less trust in the intensive care
      unit physician, male sex, and non-Catholic religious affiliation. CONCLUSIONS:
      Surrogates vary in their desire for decisional authority for value-sensitive life
      support decisions, but prefer substantially more authority for this type of
      decision compared with technical, medical judgments. Low trust in physicians is
      associated with surrogates preferring more control of life support decisions.
FAU - Johnson, Sara K
AU  - Johnson SK
AD  - Department of Medicine, University of California, San Francisco, CA, USA.
FAU - Bautista, Christopher A
AU  - Bautista CA
FAU - Hong, Seo Yeon
AU  - Hong SY
FAU - Weissfeld, Lisa
AU  - Weissfeld L
FAU - White, Douglas B
AU  - White DB
LA  - eng
GR  - 1K23AG032875/AG/NIA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20101029
PL  - United States
TA  - Am J Respir Crit Care Med
JT  - American journal of respiratory and critical care medicine
JID - 9421642
SB  - IM
CIN - Am J Respir Crit Care Med. 2011 Apr 1;183(7):840-1. PMID: 21474424
MH  - Adult
MH  - Aged
MH  - Cohort Studies
MH  - Critical Care/ethics/methods
MH  - Critical Illness/therapy
MH  - Decision Making/*ethics
MH  - Female
MH  - Humans
MH  - Informed Consent
MH  - Intensive Care Units/*ethics
MH  - Life Support Care/*ethics
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Odds Ratio
MH  - *Professional-Family Relations
MH  - Prospective Studies
MH  - *Proxy
MH  - Withholding Treatment/ethics
PMC - PMC3086756
EDAT- 2010/11/03 06:00
MHDA- 2011/06/18 06:00
CRDT- 2010/11/02 06:00
PHST- 2010/11/02 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/06/18 06:00 [medline]
AID - 201008-1214OC [pii]
AID - 10.1164/rccm.201008-1214OC [doi]
PST - ppublish
SO  - Am J Respir Crit Care Med. 2011 Apr 1;183(7):915-21. doi:
      10.1164/rccm.201008-1214OC. Epub 2010 Oct 29.


PMID- 21036630
OWN - NLM
STAT- MEDLINE
DCOM- 20101222
LR  - 20101126
IS  - 1879-1190 (Electronic)
IS  - 1072-7515 (Linking)
VI  - 211
IP  - 6
DP  - 2010 Dec
TI  - Prospective randomized single-blinded in vitro and ex vivo evaluation of new and 
      reprocessed laparoscopic trocars.
PG  - 738-43
LID - 10.1016/j.jamcollsurg.2010.08.003 [doi]
AB  - BACKGROUND: Reprocessing of single-use medical instruments has been proposed as a
      mechanism for managing the rising costs of health care. We compared the
      performance of new and reprocessed laparoscopic trocars. STUDY DESIGN: New and
      reprocessed laparoscopic trocars were evaluated. Testing consisted of visual and 
      microscopic inspection, force of trocar insertion and removal through a porcine
      abdominal wall, trocar seal leak rate determination, and testing of blade shield 
      speed. RESULTS: Three hundred twenty-eight reprocessed trocars and 199 new
      trocars were evaluated. Trocars undergoing force testing were inspected for
      imperfections. In this group, 28.2% of reprocessed and 3.79% of new trocars
      manifested some gross or microscopic imperfections (p = 0.063). D12LT trocars
      (Ethicon) required more force with insertion with reprocessed compared with new
      trocars (0.021). D5LT (Ethicon) new trocars required more force to remove than
      reprocessed trocars (p = 0.004). Both the shield cover time and the shield
      response time were found to be faster in the reprocessed (p = 0.0001) compared
      with the new trocars. Leak testing performed with probes (4.7 mm and 12.9 mm) in 
      place demonstrated a significantly greater amount of leakage for the reprocessed 
      trocars compared with the new trocars, both before and after insertion of the
      right-angled instrument (p = 0.0001). CONCLUSIONS: When comparing new and
      reprocessed trocars, there are significant differences in visual trocar defects, 
      insertion and extraction forces, shield response times, and trocar leak rates for
      some of the device comparisons. The clinical significance of these changes should
      be weighed against cost savings and environmental impact. Additional testing is
      necessary for a better understanding of the impact of trocar reprocessing.
CI  - Copyright (c) 2010 American College of Surgeons. Published by Elsevier Inc. All
      rights reserved.
FAU - Mues, Adam C
AU  - Mues AC
AD  - Department of Urology, Columbia University Medical Center, New York, NY, USA.
      adammues@gmail.com
FAU - Haramis, Georgios
AU  - Haramis G
FAU - Casazza, Cristin
AU  - Casazza C
FAU - Okhunov, Zhamshid
AU  - Okhunov Z
FAU - Badani, Ketan K
AU  - Badani KK
FAU - Landman, Jaime
AU  - Landman J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20101030
PL  - United States
TA  - J Am Coll Surg
JT  - Journal of the American College of Surgeons
JID - 9431305
SB  - IM
MH  - Animals
MH  - *Disposable Equipment/microbiology/standards
MH  - Equipment Safety
MH  - Laparoscopy/*instrumentation
MH  - Prospective Studies
MH  - Single-Blind Method
MH  - *Sterilization
MH  - Surgical Instruments/*standards
MH  - Swine
EDAT- 2010/11/03 06:00
MHDA- 2010/12/24 06:00
CRDT- 2010/11/02 06:00
PHST- 2010/06/25 00:00 [received]
PHST- 2010/08/05 00:00 [revised]
PHST- 2010/08/05 00:00 [accepted]
PHST- 2010/11/02 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2010/12/24 06:00 [medline]
AID - S1072-7515(10)00939-7 [pii]
AID - 10.1016/j.jamcollsurg.2010.08.003 [doi]
PST - ppublish
SO  - J Am Coll Surg. 2010 Dec;211(6):738-43. doi: 10.1016/j.jamcollsurg.2010.08.003.
      Epub 2010 Oct 30.


PMID- 21036563
OWN - NLM
STAT- MEDLINE
DCOM- 20110425
LR  - 20101214
IS  - 1769-664X (Electronic)
IS  - 0929-693X (Linking)
VI  - 17
IP  - 12
DP  - 2010 Dec
TI  - [The alliance of the parent, child and the nurse to challenge medical error].
PG  - 1696-708
LID - 10.1016/j.arcped.2010.09.014 [doi]
AB  - A group composed of parents, nurses, and physicians involved in pediatric
      cancerology has reflected on medical errors within the Espace Ethique de
      l'Assistance publique-Hopitaux de Paris. Based on narratives and qualitative
      analysis of histories and testimonies, this discussion aimed at exploring the
      causes, circumstances, and impacts of medical errors on the relations between
      these individuals. The study demonstrated that some circumstances actually
      promote medical errors, such as hard working conditions, mistrust, unreliable
      control procedures, not listening to parents, and caring for children in extreme 
      situations of pain and suffering. Errors almost always result from the
      accumulation of several shortcomings. The tensions raised by a medical error can 
      be overcome, provided that parents and caregivers trust each other from the onset
      of disease and that the medical errors are disclosed in a sincere way, whatever
      the medical consequences. The feelings raised by the painful experience of a
      medical error do not solely depend on the severity of the consequences, since
      seemingly benign errors may lead to long-term trauma, whereas severe errors, even
      those leading to death, do not necessarily breach trust. The keyword here is
      permanent vigilance. The capacity of caregivers to question their practice, from 
      both a technical and ethical point of view, will determine their ability to learn
      from an error for the future. The depth and quality of this questioning, in the
      best of times encouraged by the institution, may also help children affected by a
      medical error and their family to move forward in their personal history, beyond 
      such painful experiences.
CI  - Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
FAU - Davous, D
AU  - Davous D
AD  - AP-HP, CHU Saint-Louis, Paris, France. davous@ccr.jussieu.fr
FAU - Seigneur, E
AU  - Seigneur E
FAU - Auvrignon, A
AU  - Auvrignon A
FAU - Kerjosse, B
AU  - Kerjosse B
FAU - Asselain, B
AU  - Asselain B
FAU - Brugieres, L
AU  - Brugieres L
FAU - Cerny, C
AU  - Cerny C
FAU - Corroyez, F
AU  - Corroyez F
FAU - Desdouits, F
AU  - Desdouits F
FAU - Heard, M
AU  - Heard M
FAU - Souyri, V
AU  - Souyri V
FAU - Vialle, G
AU  - Vialle G
FAU - Velter, N
AU  - Velter N
FAU - Bourdeaut, F
AU  - Bourdeaut F
CN  - groupe de reflexion et de recherche au sein de l'Espace ethique AP-HP : <<
      Parents et soignants face a l'ethique en pediatrie >>
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - L'alliance parents-enfant-soignants a l'epreuve de l'erreur medicale.
DEP - 20101030
PL  - France
TA  - Arch Pediatr
JT  - Archives de pediatrie : organe officiel de la Societe francaise de pediatrie
JID - 9421356
SB  - IM
MH  - Child
MH  - Delivery of Health Care/ethics/*standards
MH  - France
MH  - Humans
MH  - *Medical Errors/ethics
MH  - *Nurses
MH  - *Parents
MH  - Physicians/*ethics
MH  - Risk Factors
MH  - Trust
MH  - Truth Disclosure/*ethics
MH  - Workload
EDAT- 2010/11/03 06:00
MHDA- 2011/04/26 06:00
CRDT- 2010/11/02 06:00
PHST- 2010/05/12 00:00 [received]
PHST- 2010/09/20 00:00 [accepted]
PHST- 2010/11/02 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/04/26 06:00 [medline]
AID - S0929-693X(10)00414-8 [pii]
AID - 10.1016/j.arcped.2010.09.014 [doi]
PST - ppublish
SO  - Arch Pediatr. 2010 Dec;17(12):1696-708. doi: 10.1016/j.arcped.2010.09.014. Epub
      2010 Oct 30.


PMID- 21036545
OWN - NLM
STAT- MEDLINE
DCOM- 20110324
LR  - 20111117
IS  - 1873-569X (Electronic)
IS  - 0923-1811 (Linking)
VI  - 60
IP  - 3
DP  - 2010 Dec
TI  - The advantages of hair follicle pluripotent stem cells over embryonic stem cells 
      and induced pluripotent stem cells for regenerative medicine.
PG  - 131-7
LID - 10.1016/j.jdermsci.2010.09.007 [doi]
AB  - Multipotent adult stem cells have many potential therapeutic applications. Our
      recent findings suggest that hair follicles are a promising source of easily
      accessible multipotent stem cells. Stem cells in the hair follicle area express
      the neural stem cell marker nestin, suggesting that hair-follicle stem cells and 
      neural stem cells have common features. Nestin-expressing hair follicle stem
      cells can form neurons and other cell types, and thus adult hair follicle stem
      cells could have important therapeutic applications, particularly for neurologic 
      diseases. Transplanted hair follicle stem cells promote the functional recovery
      of injured peripheral nerve and spinal cord. Recent findings suggest that direct 
      transplantation of hair-follicle stem cells without culture can promote nerve
      repair, which makes them potentially clinically practical. Human hair follicle
      stem cells as well as mouse hair follicle stem cells promote nerve repair and can
      be applied to test the hypothesis that human hair follicle stem cells can provide
      a readily available source of neurologically therapeutic stem cells. The use of
      hair follicle stem cells for nerve regeneration overcomes critical problems of
      embryonic stem cells or induced pluripotent stem cells in that the hair follicle 
      stem cells are multipotent, readily accessible, non-oncogenic, and are not
      associated with ethical issues.
CI  - Copyright (c) 2010 Japanese Society for Investigative Dermatology. Published by
      Elsevier Ireland Ltd. All rights reserved.
FAU - Amoh, Yasuyuki
AU  - Amoh Y
AD  - Department of Dermatology, Kitasato University School of Medicine, Sagamihara,
      Japan. amo@med.kitasato-u.ac.jp
FAU - Katsuoka, Kensei
AU  - Katsuoka K
FAU - Hoffman, Robert M
AU  - Hoffman RM
LA  - eng
GR  - AR050933-01/AR/NIAMS NIH HHS/United States
GR  - AR050933-02A1/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20101001
PL  - Netherlands
TA  - J Dermatol Sci
JT  - Journal of dermatological science
JID - 9011485
SB  - IM
MH  - Adult
MH  - Animals
MH  - Cell Differentiation
MH  - Embryonic Stem Cells/cytology
MH  - Hair Follicle/*cytology
MH  - Humans
MH  - Induced Pluripotent Stem Cells/cytology
MH  - Keratinocytes/cytology
MH  - Mice
MH  - *Nerve Regeneration
MH  - Peripheral Nerve Injuries
MH  - Pluripotent Stem Cells/*cytology/transplantation
MH  - *Stem Cell Transplantation/methods
EDAT- 2010/11/03 06:00
MHDA- 2011/03/25 06:00
CRDT- 2010/11/02 06:00
PHST- 2010/05/20 00:00 [received]
PHST- 2010/09/21 00:00 [revised]
PHST- 2010/09/24 00:00 [accepted]
PHST- 2010/11/02 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/03/25 06:00 [medline]
AID - S0923-1811(10)00297-5 [pii]
AID - 10.1016/j.jdermsci.2010.09.007 [doi]
PST - ppublish
SO  - J Dermatol Sci. 2010 Dec;60(3):131-7. doi: 10.1016/j.jdermsci.2010.09.007. Epub
      2010 Oct 1.


PMID- 21036294
OWN - NLM
STAT- MEDLINE
DCOM- 20101112
LR  - 20211203
IS  - 1097-6760 (Electronic)
IS  - 0196-0644 (Linking)
VI  - 56
IP  - 5
DP  - 2010 Nov
TI  - NIH Roundtable on Emergency Trauma Research.
PG  - 538-50
LID - 10.1016/j.annemergmed.2010.05.029 [doi]
AB  - STUDY OBJECTIVE: The National Institutes of Health (NIH) formed an NIH Task Force
      on Research in Emergency Medicine to enhance NIH support for emergency care
      research. The NIH Trauma Research Roundtable was convened on June 22 to 23, 2009.
      The objectives of the roundtable are to identify key research questions essential
      to advancing the scientific underpinnings of emergency trauma care and to discuss
      the barriers and best means to advance research by exploring the role of trauma
      research networks and collaboration between NIH and the emergency trauma care
      community. METHODS: Before the roundtable, the emergency care domains to be
      discussed were selected and experts in each of the fields were invited to
      participate in the roundtable. Domain experts were asked to identify research
      priorities and challenges and separate them into mechanistic, translational, and 
      clinical categories. During and after the conference, the lists were circulated
      among the participants and revised to reach a consensus. RESULTS: Emergency
      trauma care research is characterized by focus on the timing, sequence, and time 
      sensitivity of disease processes and treatment effects. Rapidly identifying the
      phenotype of patients on the time spectrum of acuity and severity after injury
      and the mechanistic reasons for heterogeneity in outcome are important challenges
      in emergency trauma research. Other research priorities include the need to
      elucidate the timing, sequence, and duration of causal molecular and cellular
      events involved in time-critical injuries, and the development of treatments
      capable of halting or reversing them; the need for novel experimental models of
      acute injury; the need to assess the effect of development and aging on the
      postinjury response; and the need to understand why there are regional
      differences in outcomes after injury. Important barriers to emergency care
      research include a limited number of trained investigators and experienced
      mentors, limited research infrastructure and support, and regulatory hurdles.
      CONCLUSION: The science of emergency trauma care may be advanced by facilitating 
      the following: (1) development of an acute injury template for clinical research;
      (2) developing emergency trauma clinical research networks; (3) integrating
      emergency trauma research into Clinical and Translational Science Awards; (4)
      developing emergency care-specific initiatives within the existing structure of
      NIH institutes and centers; (5) involving acute trauma and emergency specialists 
      in grant review and research advisory processes; (6) supporting learn-phase or
      small, clinical trials; (7) performing research to address ethical and regulatory
      issues; and (8) training emergency care investigators with research training
      programs.
CI  - Copyright (c) 2010 American College of Emergency Physicians. Published by Mosby, 
      Inc. All rights reserved.
FAU - Cairns, Charles B
AU  - Cairns CB
AD  - Department of Emergency Medicine, University of North Carolina, 170 Manning Dr,
      Chapel Hill, NC 27599, USA. ccairns@med.unc.edu
FAU - Maier, Ronald V
AU  - Maier RV
FAU - Adeoye, Opeolu
AU  - Adeoye O
FAU - Baptiste, Darryl
AU  - Baptiste D
FAU - Barsan, William G
AU  - Barsan WG
FAU - Blackbourne, Lorne
AU  - Blackbourne L
FAU - Burd, Randall
AU  - Burd R
FAU - Carpenter, Christopher
AU  - Carpenter C
FAU - Chang, David
AU  - Chang D
FAU - Cioffi, William
AU  - Cioffi W
FAU - Cornwell, Edward
AU  - Cornwell E
FAU - Dean, J Michael
AU  - Dean JM
FAU - Dyer, Carmel
AU  - Dyer C
FAU - Jaffe, David
AU  - Jaffe D
FAU - Manley, Geoff
AU  - Manley G
FAU - Meurer, William J
AU  - Meurer WJ
FAU - Neumar, Robert
AU  - Neumar R
FAU - Silbergleit, Robert
AU  - Silbergleit R
FAU - Stevens, Molly
AU  - Stevens M
FAU - Wang, Michael
AU  - Wang M
FAU - Weiner, Debra
AU  - Weiner D
FAU - Wright, David
AU  - Wright D
CN  - Roundtable External Participants and Roundtable Steering Committee and Federal
      Participants
LA  - eng
PT  - Consensus Development Conference, NIH
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Ann Emerg Med
JT  - Annals of emergency medicine
JID - 8002646
SB  - IM
MH  - Advisory Committees
MH  - *Biomedical Research
MH  - Central Nervous System/injuries
MH  - Clinical Trials as Topic
MH  - *Emergency Medical Services
MH  - Emergency Medicine/education
MH  - Humans
MH  - *National Institutes of Health (U.S.)
MH  - Needs Assessment
MH  - Shock, Hemorrhagic/etiology/therapy
MH  - Translational Research, Biomedical
MH  - United States
MH  - Workforce
MH  - Wounds and Injuries/*therapy
IR  - Cairns CB
FIR - Cairns, Charles B
IR  - Maier RV
FIR - Maier, Ronald V
IR  - Adeoye O
FIR - Adeoye, Opeolu
IR  - Baptiste D
FIR - Baptiste, Darryl
IR  - Barsan WG
FIR - Barsan, William G
IR  - Blackbourne L
FIR - Blackbourne, Lorne
IR  - Burd R
FIR - Burd, Randall
IR  - Carpenter C
FIR - Carpenter, Christopher
IR  - Chang D
FIR - Chang, David
IR  - Cioffi W
FIR - Cioffi, William
IR  - Cornwell E
FIR - Cornwell, Edward
IR  - Dean JM
FIR - Dean, J Michael
IR  - Dyer C
FIR - Dyer, Carmel
IR  - Jaffe D
FIR - Jaffe, David
IR  - Manley G
FIR - Manley, Geoff
IR  - Meurer WJ
FIR - Meurer, William J
IR  - Neumar R
FIR - Neumar, Robert
IR  - Silbergleit R
FIR - Silbergleit, Robert
IR  - Stevens M
FIR - Stevens, Molly
IR  - Wang M
FIR - Wang, Michael
IR  - Weiner D
FIR - Weiner, Debra
IR  - Wright D
FIR - Wright, David
IR  - Conwit R
FIR - Conwit, Robin
IR  - Dunn B
FIR - Dunn, Billy
IR  - Eldadah B
FIR - Eldadah, Basel
IR  - Egan D
FIR - Egan, Debra
IR  - Filart R
FIR - Filart, Rosemarie
IR  - Guerrero G
FIR - Guerrero, Giovanna
IR  - Hack D
FIR - Hack, Dallas
IR  - Heppel D
FIR - Heppel, David
IR  - Hunt R
FIR - Hunt, Richard
IR  - Hicks R
FIR - Hicks, Ramona
IR  - Janis S
FIR - Janis, Scott
IR  - Kerr M
FIR - Kerr, Mary
IR  - Kleitman N
FIR - Kleitman, Naomi
IR  - Kopp J
FIR - Kopp, Jeffrey
IR  - Koroshetz WJ
FIR - Koroshetz, Walter J
IR  - Korpela J
FIR - Korpela, Jukka
IR  - Mutter R
FIR - Mutter, Ryan
IR  - Nicholson C
FIR - Nicholson, Carol
IR  - Martinelli A
FIR - Martinelli, Angela
IR  - Panagis J
FIR - Panagis, James
IR  - Scott J
FIR - Scott, Jane
IR  - Somers S
FIR - Somers, Scott
IR  - Sopko G
FIR - Sopko, George
IR  - Thurmond V
FIR - Thurmond, Veronica
IR  - Zalutsky B
FIR - Zalutsky, Bob
IR  - Cairns CB
FIR - Cairns, Charles B
IR  - Maier RV
FIR - Maier, Ronald V
IR  - Somers S
FIR - Somers, Scott
IR  - Hicks R
FIR - Hicks, Ramona
IR  - Conwit R
FIR - Conwit, Robin
IR  - Eldadah B
FIR - Eldadah, Basel
IR  - Koroshetz WJ
FIR - Koroshetz, Walter J
IR  - Guerrero G
FIR - Guerrero, Giovanna
EDAT- 2010/11/03 06:00
MHDA- 2010/11/13 06:00
CRDT- 2010/11/02 06:00
PHST- 2010/02/17 00:00 [received]
PHST- 2010/05/08 00:00 [revised]
PHST- 2010/05/11 00:00 [accepted]
PHST- 2010/11/02 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2010/11/13 06:00 [medline]
AID - S0196-0644(10)00554-8 [pii]
AID - 10.1016/j.annemergmed.2010.05.029 [doi]
PST - ppublish
SO  - Ann Emerg Med. 2010 Nov;56(5):538-50. doi: 10.1016/j.annemergmed.2010.05.029.


PMID- 21036293
OWN - NLM
STAT- MEDLINE
DCOM- 20101112
LR  - 20191210
IS  - 1097-6760 (Electronic)
IS  - 0196-0644 (Linking)
VI  - 56
IP  - 5
DP  - 2010 Nov
TI  - Summary of NIH Medical-Surgical Emergency Research Roundtable held on April 30 to
      May 1, 2009.
PG  - 522-37
LID - 10.1016/j.annemergmed.2010.03.014 [doi]
AB  - STUDY OBJECTIVE: In 2003, the Institute of Medicine Committee on the Future of
      Emergency Care in the United States Health System convened and identified a
      crisis in emergency care in the United States, including a need to enhance the
      research base for emergency care. As a result, the National Institutes of Health 
      (NIH) formed an NIH Task Force on Research in Emergency Medicine to enhance NIH
      support for emergency care research. Members of the NIH Task Force and academic
      leaders in emergency care participated in 3 roundtable discussions to prioritize 
      current opportunities for enhancing and conducting emergency care research. The
      objectives of these discussions were to identify key research questions essential
      to advancing the scientific underpinnings of emergency care and to discuss the
      barriers and best means to advance research by exploring the role of research
      networks and collaboration between the NIH and the emergency care community.
      METHODS: The Medical-Surgical Research Roundtable was convened on April 30 to May
      1, 2009. Before the roundtable, the emergency care domains to be discussed were
      selected and experts in each of the fields were invited to participate in the
      roundtable. Domain experts were asked to identify research priorities and
      challenges and separate them into mechanistic, translational, and clinical
      categories. After the conference, the lists were circulated among the
      participants and revised to reach a consensus. RESULTS: Emergency care research
      is characterized by focus on the timing, sequence, and time sensitivity of
      disease processes and treatment effects. Rapidly identifying the phenotype and
      genotype of patients manifesting a specific disease process and the mechanistic
      reasons for heterogeneity in outcome are important challenges in emergency care
      research. Other research priorities include the need to elucidate the timing,
      sequence, and duration of causal molecular and cellular events involved in
      time-critical illnesses and injuries, and the development of treatments capable
      of halting or reversing them; the need for novel animal models; and the need to
      understand why there are regional differences in outcome for the same disease
      processes. Important barriers to emergency care research include a limited number
      of trained investigators and experienced mentors, limited research infrastructure
      and support, and regulatory hurdles. The science of emergency care may be
      advanced by facilitating the following: (1) training emergency care investigators
      with research training programs; (2) developing emergency care clinical research 
      networks; (3) integrating emergency care research into Clinical and Translational
      Science Awards; (4) developing emergency care-specific initiatives within the
      existing structure of NIH institutes and centers; (5) involving emergency
      specialists in grant review and research advisory processes; (6) supporting
      learn-phase or small, clinical trials; and (7) performing research to address
      ethical and regulatory issues. CONCLUSION: Enhancing the research base supporting
      the care of medical and surgical emergencies will require progress in specific
      mechanistic, translational, and clinical domains; effective collaboration of
      academic investigators across traditional clinical and scientific boundaries;
      federal support of research in high-priority areas; and overcoming limitations in
      available infrastructure, research training, and access to patient populations.
CI  - Copyright (c) 2010 American College of Emergency Physicians. Published by Mosby, 
      Inc. All rights reserved.
FAU - Kaji, Amy H
AU  - Kaji AH
AD  - Department of Emergency Medicine, Harbor-UCLA Medical Center, 1000 W. Carson
      Street, Box 21, Torrance, CA 90509- 2910, USA. akaji@emedharbor.edu
FAU - Lewis, Roger J
AU  - Lewis RJ
FAU - Beavers-May, Tony
AU  - Beavers-May T
FAU - Berg, Robert
AU  - Berg R
FAU - Bulger, Eileen
AU  - Bulger E
FAU - Cairns, Charles
AU  - Cairns C
FAU - Callaway, Clifton
AU  - Callaway C
FAU - Camargo, Carlos A Jr
AU  - Camargo CA Jr
FAU - Carcillo, Joseph
AU  - Carcillo J
FAU - DeBiasi, Roberta
AU  - DeBiasi R
FAU - Diaz, Tania
AU  - Diaz T
FAU - Ducharme, Francine
AU  - Ducharme F
FAU - Glickman, Seth
AU  - Glickman S
FAU - Heilpern, Katherine
AU  - Heilpern K
FAU - Hickey, Robert
AU  - Hickey R
FAU - Hoek, Terry Vanden
AU  - Hoek TV
FAU - Hollander, Judd
AU  - Hollander J
FAU - Janson, Susan
AU  - Janson S
FAU - Jurkovich, Gregory
AU  - Jurkovich G
FAU - Kellermann, Arthur
AU  - Kellermann A
FAU - Kingsmore, Stephen
AU  - Kingsmore S
FAU - Kline, Jeffrey
AU  - Kline J
FAU - Kuppermann, Nathan
AU  - Kuppermann N
FAU - Lowe, Robert
AU  - Lowe R
FAU - McLario, David
AU  - McLario D
FAU - Nathanson, Larry
AU  - Nathanson L
FAU - Nichol, Graham
AU  - Nichol G
FAU - Peitzman, Andrew
AU  - Peitzman A
FAU - Richardson, Lynne
AU  - Richardson L
FAU - Sanders, Arthur
AU  - Sanders A
FAU - Shah, Manish
AU  - Shah M
FAU - Shapiro, Nathan
AU  - Shapiro N
FAU - Silverman, Robert
AU  - Silverman R
FAU - Than, Martin
AU  - Than M
FAU - Wilber, Scott
AU  - Wilber S
FAU - Yealy, Donald M
AU  - Yealy DM
CN  - Roundtable External Participants and Roundtable Steering Committee and Federal
      Participants
LA  - eng
PT  - Consensus Development Conference, NIH
PT  - Journal Article
PL  - United States
TA  - Ann Emerg Med
JT  - Annals of emergency medicine
JID - 8002646
SB  - IM
MH  - Advisory Committees
MH  - *Biomedical Research
MH  - Cardiopulmonary Resuscitation
MH  - Chest Pain/therapy
MH  - Computational Biology
MH  - Emergencies
MH  - *Emergency Medical Services/organization & administration
MH  - Gastrointestinal Diseases/therapy
MH  - Health Services Research
MH  - Humans
MH  - Hypersensitivity/therapy
MH  - Infections/therapy
MH  - *National Institutes of Health (U.S.)/organization & administration
MH  - Reperfusion Injury/therapy
MH  - Research
MH  - Research Support as Topic
MH  - Respiratory Tract Diseases/therapy
MH  - Sepsis/therapy
MH  - Shock, Septic/therapy
MH  - United States
IR  - Kaji AH
FIR - Kaji, Amy H
IR  - Lewis RJ
FIR - Lewis, Roger J
IR  - Beavers-May T
FIR - Beavers-May, Toni
IR  - Berg R
FIR - Berg, Robert
IR  - Brown J
FIR - Brown, Jeremy
IR  - Bulger E
FIR - Bulger, Eileen
IR  - Cairns C
FIR - Cairns, Charles
IR  - Callaway C
FIR - Callaway, Clifton
IR  - Camargo CA Jr
FIR - Camargo, Carlos A Jr
IR  - Carcillo J
FIR - Carcillo, Joseph
IR  - DeBiasi R
FIR - DeBiasi, Roberta
IR  - Diaz T
FIR - Diaz, Tania
IR  - Ducharme F
FIR - Ducharme, Francine
IR  - Glickman S
FIR - Glickman, Seth
IR  - Heilpern K
FIR - Heilpern, Katherine
IR  - Hickey R
FIR - Hickey, Robert
IR  - Hoek TV
FIR - Hoek, Terry Vanden
IR  - Hollander J
FIR - Hollander, Judd
IR  - Janson S
FIR - Janson, Susan
IR  - Jurkovich G
FIR - Jurkovich, Gregory
IR  - Kellermann A
FIR - Kellermann, Arthur
IR  - Kingsmore S
FIR - Kingsmore, Stephen
IR  - Kline J
FIR - Kline, Jeffrey
IR  - Kuppermann N
FIR - Kuppermann, Nathan
IR  - Lowe R
FIR - Lowe, Robert
IR  - McLario D
FIR - McLario, David
IR  - Nathanson L
FIR - Nathanson, Larry
IR  - Nichol G
FIR - Nichol, Graham
IR  - Peitzman A
FIR - Peitzman, Andrew
IR  - Richardson L
FIR - Richardson, Lynne
IR  - Sanders A
FIR - Sanders, Arthur
IR  - Shah M
FIR - Shah, Manish
IR  - Shapiro N
FIR - Shapiro, Nathan
IR  - Silverman R
FIR - Silverman, Robert
IR  - Than M
FIR - Than, Martin
IR  - Wilber S
FIR - Wilber, Scott
IR  - Yealy D
FIR - Yealy, Donald
IR  - Akhyani N
FIR - Akhyani, Nahid
IR  - Arcuri G
FIR - Arcuri, Guy
IR  - Auchincloss H
FIR - Auchincloss, Hugh
IR  - Dunsmore S
FIR - Dunsmore, Sarah
IR  - Eldadah B
FIR - Eldadah, Basil
IR  - Filart R
FIR - Filart, Rosemarie
IR  - Guerrero G
FIR - Guerrero, Giovanna
IR  - Handrigan M
FIR - Handrigan, Michael
IR  - Hirschfeld S
FIR - Hirschfeld, Steven
IR  - Hubbard V
FIR - Hubbard, Van
IR  - Hunt R
FIR - Hunt, Richard
IR  - Huss K
FIR - Huss, Karen
IR  - Kavanaugh D
FIR - Kavanaugh, Daniel
IR  - Kimmel P
FIR - Kimmel, Paul
IR  - Kitt C
FIR - Kitt, Cheryl
IR  - Kopp J
FIR - Kopp, Jeffrey
IR  - Korpela J
FIR - Korpela, Jukka
IR  - Mascette A
FIR - Mascette, Alice
IR  - McDonald C
FIR - McDonald, Clement
IR  - Miers S
FIR - Miers, Sarah
IR  - Mutter R
FIR - Mutter, Ryan
IR  - Somers S
FIR - Somers, Scott
IR  - Sopko G
FIR - Sopko, George
IR  - Tai B
FIR - Tai, Betty
IR  - Togias A
FIR - Togias, Alkis
IR  - Wadhwani K
FIR - Wadhwani, Kishena
IR  - Wright K
FIR - Wright, Kevin
IR  - Cairns C
FIR - Cairns, Charles
IR  - Camargo CA Jr
FIR - Camargo, Carlos A Jr
IR  - Jurkovich G
FIR - Jurkovich, Gregory
IR  - Kellermann A
FIR - Kellermann, Arthur
IR  - Lewis RJ
FIR - Lewis, Roger J
IR  - Shapiro N
FIR - Shapiro, Nathan
IR  - Dunsmore S
FIR - Dunsmore, Sarah
IR  - Egan D
FIR - Egan, Debra
IR  - Eldadah B
FIR - Eldadah, Basil
IR  - Handrigan M
FIR - Handrigan, Michael
IR  - Hunt R
FIR - Hunt, Richard
IR  - Huss K
FIR - Huss, Karen
IR  - Kavanaugh D
FIR - Kavanaugh, Daniel
IR  - Kopp J
FIR - Kopp, Jeffrey
IR  - Korpela J
FIR - Korpela, Jukka
IR  - Mascette A
FIR - Mascette, Alice
IR  - Mutter R
FIR - Mutter, Ryan
IR  - Somers S
FIR - Somers, Scott
IR  - Sopko G
FIR - Sopko, George
EDAT- 2010/11/03 06:00
MHDA- 2010/11/13 06:00
CRDT- 2010/11/02 06:00
PHST- 2010/02/04 00:00 [received]
PHST- 2010/02/04 00:00 [revised]
PHST- 2010/03/04 00:00 [accepted]
PHST- 2010/11/02 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2010/11/13 06:00 [medline]
AID - S0196-0644(10)00233-7 [pii]
AID - 10.1016/j.annemergmed.2010.03.014 [doi]
PST - ppublish
SO  - Ann Emerg Med. 2010 Nov;56(5):522-37. doi: 10.1016/j.annemergmed.2010.03.014.


PMID- 21034512
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1478-4505 (Electronic)
IS  - 1478-4505 (Linking)
VI  - 8
DP  - 2010 Oct 31
TI  - Research workshop to research work: initial steps in establishing health research
      systems on Malaita, Solomon Islands.
PG  - 33
LID - 10.1186/1478-4505-8-33 [doi]
AB  - INTRODUCTION: Atoifi Adventist Hospital is a 90 bed general hospital in East
      Kwaio, Malaita, Solomon Islands providing services to the population of
      subsistence villagers of the region. Health professionals at the hospital and
      attached College of Nursing have considerable human capacity and willingness to
      undertake health research. However they are constrained by limited research
      experience, training opportunities, research systems, physical infrastructure and
      access to resources. This brief commentary describes an 'Introduction to Health
      Research' workshop delivered at Atoifi Adventist Hospital in September 2009 and
      efforts to move from 'research workshop' to 'research work'. THE APPROACH: Using 
      a participatory-action research approach underpinned by decolonising
      methodologies, staff from Atoifi Adventist Hospital and James Cook University
      (Queensland, Australia) collaboratively designed, implemented and evaluated a
      health research workshop. Basic health research principles and methods were
      presented using active learning methodologies. Following the workshop, Atoifi
      Adventist Hospital and Atoifi College of Nursing staff, other professionals and
      community members reported an increased awareness and understanding of health
      research. The formation of a local Research Committee, improved ethics review
      procedures and the identification of local research mentors followed the week
      long workshop. The workshop has acted as a catalyst for research activity,
      increasing structural and human resource capacity for local health professionals 
      and community leaders to engage in research. DISCUSSION AND CONCLUSIONS:
      Participants from a variety of educational backgrounds participated in, and
      received benefit from, a responsive, culturally and linguistically accessible
      health research workshop. Improving health research systems at a remote hospital 
      and aligning these with local and national research agendas is establishing a
      base to strengthen public health research and practice on Malaita, Solomon
      Islands.
FAU - Redman-Maclaren, Michelle L
AU  - Redman-Maclaren ML
AD  - School of Public Health, Tropical Medicine and Rehabilitation Sciences, James
      Cook University, McGregor Rd, Smithfield, Cairns, Australia.
      michelle.maclaren@jcu.edu.au.
FAU - Maclaren, David J
AU  - Maclaren DJ
FAU - Solomon, Janella
AU  - Solomon J
FAU - Muse, Alwin
AU  - Muse A
FAU - Asugeni, Rowena
AU  - Asugeni R
FAU - Harrington, Humpress
AU  - Harrington H
FAU - Kekuabata, Esau
AU  - Kekuabata E
FAU - Speare, Richard
AU  - Speare R
FAU - Clough, Alan R
AU  - Clough AR
LA  - eng
PT  - Editorial
DEP - 20101031
PL  - England
TA  - Health Res Policy Syst
JT  - Health research policy and systems
JID - 101170481
PMC - PMC2978209
EDAT- 2010/11/03 06:00
MHDA- 2010/11/03 06:01
CRDT- 2010/11/02 06:00
PHST- 2010/06/24 00:00 [received]
PHST- 2010/10/31 00:00 [accepted]
PHST- 2010/11/02 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2010/11/03 06:01 [medline]
AID - 1478-4505-8-33 [pii]
AID - 10.1186/1478-4505-8-33 [doi]
PST - epublish
SO  - Health Res Policy Syst. 2010 Oct 31;8:33. doi: 10.1186/1478-4505-8-33.


PMID- 21033633
OWN - NLM
STAT- MEDLINE
DCOM- 20101216
LR  - 20161125
IS  - 1477-7266 (Print)
IS  - 1477-7266 (Linking)
VI  - 24
IP  - 4
DP  - 2010
TI  - Don't stop the clock: manipulating hospital waiting lists.
PG  - 343-60
AB  - PURPOSE: This paper aims to explore the theoretical and practical management
      implications of a case involving the falsification of hospital patient waiting
      lists for elective orthopaedic surgery. DESIGN/METHODOLOGY/APPROACH: This case
      study is based on qualitative schedule-structured interviews with 20 senior
      hospital staff (managerial and clinical), including the head of the investigation
      team, downloads from the hospital website, and internal hospital documentation.
      Those data were used to construct an event narrative exploring the underlying
      causes and implications of the incident. FINDINGS: The blame for misconduct
      pointed at three surgeons, a senior manager, a general manager, an assistant
      general manager, one administrative staff member, and several organizational
      factors. In addition to censuring some of those involved, an investigation
      recommended changes to training and working practices, policies and procedures,
      governance arrangements, and organization culture, and led to an external
      evaluation of the hospital board. However, one year later, another similar
      incident occurred. RESEARCH LIMITATIONS/IMPLICATIONS: This is a single case, and 
      events are viewed through a management lens, the individuals concerned being
      protected by research ethics considerations. PRACTICAL IMPLICATIONS: By detailing
      the sequence of events, surrounding conditions, and the reactions of multiple
      players, this analysis reveals typified responses to incidents of this kind, and 
      the limitations inherent in post-event investigations. If the benefits derived
      from national targets are to be realized in a manner which commands support from 
      staff at all levels, then greater attention should be paid by managers and
      regulators to issues of transparency, responsiveness, and honesty. As core
      dimensions of good governance, managers must be accountable for helping to meet
      targets, and also for tracking how targets are met, ensuring that resources are
      made available, and that problematic issues raised are promptly and effectively
      addressed. ORIGINALITY/VALUE: Studies of organizational misbehaviour are rare in 
      healthcare where the focus often lies with patient deaths and injuries arising
      from system failures and gross individual misconduct. The analysis in this case
      explores the organizational conditions that contribute to such incidents.
FAU - Buchanan, David A
AU  - Buchanan DA
AD  - Cranfield University School of Management, Cranfield, UK.
      David.Buchanan@Cranfield.ac.uk
FAU - Storey, John
AU  - Storey J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Health Organ Manag
JT  - Journal of health organization and management
JID - 101179473
MH  - *Documentation
MH  - Elective Surgical Procedures
MH  - *Fraud
MH  - *Hospital Administration
MH  - Humans
MH  - Interviews as Topic
MH  - Orthopedics
MH  - *Professional Misconduct
MH  - United Kingdom
MH  - *Waiting Lists
EDAT- 2010/11/03 06:00
MHDA- 2010/12/17 06:00
CRDT- 2010/11/02 06:00
PHST- 2010/11/02 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2010/12/17 06:00 [medline]
AID - 10.1108/14777261011064977 [doi]
PST - ppublish
SO  - J Health Organ Manag. 2010;24(4):343-60. doi: 10.1108/14777261011064977.


PMID- 21033624
OWN - NLM
STAT- MEDLINE
DCOM- 20101123
LR  - 20161026
IS  - 0006-9248 (Print)
IS  - 0006-9248 (Linking)
VI  - 111
IP  - 8
DP  - 2010
TI  - Protection of ovarian tissue from radiotherapy.
PG  - 443-8
AB  - Advances researches in the diagnosis and treatment of childhood, adolescent and
      adult cancer have greatly increased the life expectancy of premenopausal women
      with cancer. However, one of the serious side effects of these treatments is the 
      risk of damage to fertility. The ovaries are very sensitive to cytotoxic and
      radiotherapeutic treatment. The only established method of fertility preservation
      is embryo cryopreservation according to the Ethics Committee of the American
      Society for Reproductive Medicine (2005), but this option requires the patient to
      be of pubertal age, have a partner or use donor sperm, and be able to undergo a
      cycle of ovarian stimulation, which is not possible when the radiotherapy has to 
      be initiated immediately or when stimulation is contraindicated according to the 
      type of cancer. For patients who need immediate radiotherapy, cryopreservation of
      ovarian tissue is the only possible alternative. This manuscript reports the
      different techniques of cryopreservation and the results of transplantation of
      cryopreserved ovarian tissue. The current techniques allow cryopreservation of
      human ovarian fragments for a long time with good follicular survival rate after 
      thawing. Numerous studies ultimately in this field have demonstrated to improve
      the survival rate of the oocytes and cryopreserved follicles. Moreover this
      manuscript includes a case of a 17-year-old girl who had to undergo pelvic
      irradiation for non-Hodgkin's lymphoma and the laparoscopic treatment to preserve
      the fertility (Fig. 2, Ref. 47).
FAU - Pafumi, C
AU  - Pafumi C
AD  - Department of Obstetrics and Gynaecology, University of Catania, Italy.
      pafumi@unict.it
FAU - Iraci, S M
AU  - Iraci SM
FAU - Abbate, G
AU  - Abbate G
FAU - Clemente, C M
AU  - Clemente CM
FAU - La Rosa, I
AU  - La Rosa I
FAU - Gulino, F A
AU  - Gulino FA
FAU - Iemmola, A
AU  - Iemmola A
FAU - Randazzo, C
AU  - Randazzo C
FAU - Caldaci, L
AU  - Caldaci L
FAU - Teodoro, M C
AU  - Teodoro MC
FAU - Palumbo, M A
AU  - Palumbo MA
FAU - Attard, M
AU  - Attard M
FAU - Ciotta, L
AU  - Ciotta L
FAU - Stracquadanio, M G
AU  - Stracquadanio MG
FAU - Messina, A
AU  - Messina A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Slovakia
TA  - Bratisl Lek Listy
JT  - Bratislavske lekarske listy
JID - 0065324
SB  - IM
MH  - Adolescent
MH  - *Cryopreservation/methods
MH  - Female
MH  - Fertility/radiation effects
MH  - Humans
MH  - Neoplasms/radiotherapy
MH  - *Ovary/radiation effects/transplantation
MH  - Pelvis/radiation effects
MH  - Tissue and Organ Harvesting/methods
EDAT- 2010/11/03 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/11/02 06:00
PHST- 2010/11/02 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - Bratisl Lek Listy. 2010;111(8):443-8.


PMID- 21033605
OWN - NLM
STAT- MEDLINE
DCOM- 20101130
LR  - 20211020
IS  - 0193-7758 (Print)
IS  - 0193-7758 (Linking)
VI  - 32
IP  - 5
DP  - 2010 Sep-Oct
TI  - IRBs and ethically challenging protocols: views of IRB chairs about useful
      resources.
PG  - 10-9
FAU - Sirotin, Nicole
AU  - Sirotin N
AD  - Albert Einstein College of Medicine/Montefiore Medical Center, New York, NY, USA.
FAU - Wolf, Leslie E
AU  - Wolf LE
FAU - Pollack, Lance M
AU  - Pollack LM
FAU - Catania, Joseph A
AU  - Catania JA
FAU - Dolcini, M Margaret
AU  - Dolcini MM
FAU - Lo, Bernard
AU  - Lo B
LA  - eng
GR  - R01 MH064696-01A1/MH/NIMH NIH HHS/United States
GR  - R01 MH064696/MH/NIMH NIH HHS/United States
GR  - R01 MH064696-04/MH/NIMH NIH HHS/United States
GR  - 1R01 MH064696/MH/NIMH NIH HHS/United States
GR  - R01 MH064696-03/MH/NIMH NIH HHS/United States
GR  - T32 DA023356-04/DA/NIDA NIH HHS/United States
GR  - T32 DA023356/DA/NIDA NIH HHS/United States
GR  - R01 MH064696-02/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - IRB
JT  - IRB
JID - 7906878
SB  - IM
MH  - *Decision Making
MH  - *Ethics Committees, Research
MH  - *Ethics, Research
MH  - Female
MH  - Health Care Surveys
MH  - Humans
MH  - *Information Services
MH  - Male
MH  - Middle Aged
MH  - Practice Patterns, Physicians'
MH  - United States
MH  - *Vulnerable Populations
PMC - PMC3066038
MID - NIHMS276733
EDAT- 2010/11/03 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/11/02 06:00
PHST- 2010/11/02 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - IRB. 2010 Sep-Oct;32(5):10-9.


PMID- 21033603
OWN - NLM
STAT- MEDLINE
DCOM- 20101130
LR  - 20110307
IS  - 0193-7758 (Print)
IS  - 0193-7758 (Linking)
VI  - 32
IP  - 5
DP  - 2010 Sep-Oct
TI  - Ethical, evidence-based guidelines for contraceptive use in research.
PG  - 1-9
FAU - Kaposy, Chris
AU  - Kaposy C
AD  - Memorial University of Newfoundland, St. John's, NL, Canada.
FAU - Baylis, Francoise
AU  - Baylis F
LA  - eng
PT  - Journal Article
PL  - United States
TA  - IRB
JT  - IRB
JID - 7906878
SB  - IM
CIN - IRB. 2010 Nov-Dec;32(6):13-6. PMID: 21375115
MH  - *Contraception
MH  - Drug Evaluation/*ethics/standards
MH  - Ethics Committees, Research/standards
MH  - Evidence-Based Medicine
MH  - Female
MH  - *Guidelines as Topic/standards
MH  - Humans
MH  - Organizational Policy
MH  - United States
EDAT- 2010/11/03 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/11/02 06:00
PHST- 2010/11/02 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - IRB. 2010 Sep-Oct;32(5):1-9.


PMID- 21033269
OWN - NLM
STAT- MEDLINE
DCOM- 20101216
LR  - 20101029
IS  - 1541-1052 (Print)
IS  - 1541-1052 (Linking)
VI  - 17
IP  - 11
DP  - 2010 Nov
TI  - Disclose mistakes that affect multiple patients.
PG  - 124-6
AB  - Staff must have a sense of duty to patients. Policies and procedures should be
      developed to address issue. Prion diseases present the greatest ethical
      challenge.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Healthcare Benchmarks Qual Improv
JT  - Healthcare benchmarks and quality improvement
JID - 101151031
MH  - Health Facilities
MH  - Humans
MH  - *Medical Errors
MH  - Organizational Policy
MH  - *Truth Disclosure
EDAT- 2010/11/03 06:00
MHDA- 2010/12/17 06:00
CRDT- 2010/11/02 06:00
PHST- 2010/11/02 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2010/12/17 06:00 [medline]
PST - ppublish
SO  - Healthcare Benchmarks Qual Improv. 2010 Nov;17(11):124-6.


PMID- 21033223
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20220408
IS  - 0172-6390 (Print)
IS  - 0172-6390 (Linking)
VI  - 57
IP  - 101
DP  - 2010 Jul-Aug
TI  - Colorectal GISTs: from presentation to survival. An analysis of 13 cases.
PG  - 755-9
AB  - This papers is a retrospective analysis of all cases of colorectal GIST treated
      at our institution. Considering the increased interest in this pathology, in
      2008, we recently established a unit supported by Novartis in our department to
      research and treat GIST. Since then, there was a dramatic increase in the
      referral of this type of tumor to our center. Before initiating our research
      group, we had the permission of the ethics committee and the medical directors to
      study and publish the analysis of our cases. Now, we have a cohort of 98 patients
      treated during the last 10 years and from that, we selected all cases of
      Colorectal GIST's. They numbered 13 cases. We performed an analysis of these
      cases from the presentation to the results of treatment.
FAU - Linhares, Eduardo
AU  - Linhares E
AD  - Instituto Nacional do Cancer (INCA), Department of Abdominal and pelvic Surgery, 
      Praca Cruz Vermelha 23, Rio de Janeiro, Brasil 20230130.
      eduardolinhares@globo.com
FAU - Herchenhorn, Daniel
AU  - Herchenhorn D
FAU - Gil, Carlos
AU  - Gil C
FAU - Mansur, Gilberto
AU  - Mansur G
FAU - Castro, Leonaldson
AU  - Castro L
FAU - Vilhena, Bruno
AU  - Vilhena B
FAU - Romano, Sergio
AU  - Romano S
FAU - Valadao, Marcus
AU  - Valadao M
FAU - Rodrigues, Denise Bandeira
AU  - Rodrigues DB
FAU - Hugo, Jose
AU  - Hugo J
FAU - Ramos, Cintia
AU  - Ramos C
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Hepatogastroenterology
JT  - Hepato-gastroenterology
JID - 8007849
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Benzamides)
RN  - 0 (Piperazines)
RN  - 0 (Pyrimidines)
RN  - 8A1O1M485B (Imatinib Mesylate)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antineoplastic Agents/therapeutic use
MH  - Benzamides
MH  - Colorectal Neoplasms/*diagnosis/drug therapy/mortality
MH  - Female
MH  - Gastrointestinal Stromal Tumors/*diagnosis/drug therapy/mortality
MH  - Humans
MH  - Imatinib Mesylate
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Piperazines/therapeutic use
MH  - Pyrimidines/therapeutic use
MH  - Tomography, X-Ray Computed
EDAT- 2010/11/03 06:00
MHDA- 2011/01/07 06:00
CRDT- 2010/11/02 06:00
PHST- 2010/11/02 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
PST - ppublish
SO  - Hepatogastroenterology. 2010 Jul-Aug;57(101):755-9.


PMID- 21032888
OWN - NLM
STAT- MEDLINE
DCOM- 20101213
LR  - 20150730
IS  - 0285-2314 (Print)
IS  - 0285-2314 (Linking)
VI  - 45
IP  - 1
DP  - 2010
TI  - [The transition of amino acids drug development for 50 years in Japan (part
      2)--ethical drugs containing amino acids (except alpha-amino acid parenteral
      fluid)].
PG  - 30-9
AB  - There are approximately 1300 kinds of ethical drugs currently approved for use in
      Japan, excluding high molecular weight drugs and Chinese medicines. Among them,
      81 contain alpha-amino acids, though some consist of a-amino acid parenteral
      fluid and peptide-type drugs, which include ACE inhibitors. Of these, 30 kinds of
      drugs are made from both natural and non-natural amino acids, and 51 kinds of
      drugs are prepared from amino acid derivatives. All of these drugs were developed
      in the last 50 years. Amino acids moieties such as D-phenylglycine and
      D-phydroxyphenylglycine have contributed to enhancing the stability,
      absorbability, and effectiveness of many drugs, particularly antibiotics, such as
      certain types of penicillin and cephalosporin. In recent years, radioactive and
      antiviral agents containing amino acid skeletons have also been developed for use
      as anti-AIDS medications.
FAU - Arai, Yumiko
AU  - Arai Y
AD  - Japan Pharmaceutical Information Center, 2-12-15 Shibuya, Shibuya-ku, Tokyo
      150-0002.
FAU - Matsumoto, Kazuo
AU  - Matsumoto K
LA  - jpn
PT  - English Abstract
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Japan
TA  - Yakushigaku Zasshi
JT  - Yakushigaku zasshi
JID - 1267223
RN  - 0 (Amino Acids)
MH  - *Amino Acids
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Japan
MH  - Pharmacology/history
EDAT- 2010/11/03 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/11/02 06:00
PHST- 2010/11/02 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - Yakushigaku Zasshi. 2010;45(1):30-9.


PMID- 20671740
OWN - NLM
STAT- MEDLINE
DCOM- 20110208
LR  - 20190131
IS  - 0098-6577 (Print)
IS  - 0098-6577 (Linking)
IP  - 117
DP  - 2010 Aug
TI  - Stressful ethical issues in uremia therapy.
PG  - S22-32
LID - 10.1038/ki.2010.190 [doi]
AB  - The objectives of this review are to introduce and explore the following
      representative ethical problems generated by modern renal replacement therapy:
      (1) reviewing the historical origin of medical ethics with specific reference to 
      nephrology; (2) recognizing the complex stresses surrounding assignment of a
      deceased donor renal transplant to a geriatric patient while young patients
      continue waiting for a donor kidney; and (3) appreciating the concept of futility
      and support for a uremic patient opting for death rather than further uremia
      therapy as the best in choice in coping with renal failure.
FAU - Friedman, Eli A
AU  - Friedman EA
AD  - Downstate Medical Center, Brooklyn, New York 11203, USA.
      eli.friedman@downstate.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Kidney Int Suppl
JT  - Kidney international. Supplement
JID - 7508622
SB  - IM
MH  - Aged
MH  - Ethics, Medical
MH  - Hemodialysis, Home/economics
MH  - Humans
MH  - Kidney Transplantation/economics/ethics
MH  - Living Donors
MH  - Mental Competency/legislation & jurisprudence
MH  - Patient Compliance/psychology
MH  - Renal Dialysis/ethics
MH  - Renal Replacement Therapy/*ethics
MH  - Tissue and Organ Procurement/economics/ethics
MH  - Treatment Refusal/ethics
MH  - Uremia/*therapy
EDAT- 2010/11/03 06:00
MHDA- 2011/02/09 06:00
CRDT- 2010/07/31 06:00
PHST- 2010/07/31 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2011/02/09 06:00 [medline]
AID - S0085-2538(15)54465-7 [pii]
AID - 10.1038/ki.2010.190 [doi]
PST - ppublish
SO  - Kidney Int Suppl. 2010 Aug;(117):S22-32. doi: 10.1038/ki.2010.190.


PMID- 33841745
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210416
IS  - 1992-0636 (Electronic)
IS  - 1992-0628 (Linking)
VI  - 5
IP  - 1
DP  - 2010 Nov
TI  - Ethics of primate use.
PG  - 11-22
LID - 10.5194/asr-5-11-2010 [doi]
AB  - This article provides an overview of the ethical issues raised by the use of
      non-human primates (NHPs) in research involving scientific procedures which may
      cause pain, suffering, distress or lasting harm. It is not an exhaustive review
      of the literature and views on this subject, and it does not present any
      conclusions about the moral acceptability or otherwise of NHP research. Rather
      the aim has been to identify the ethical issues involved and to provide guidance 
      on how these might be addressed, in particular by carefully examining the
      scientific rationale for NHP use, implementing fully the 3Rs principle of Russell
      and Burch (1959) and applying a robust "harm-benefit assessment" to research
      proposals involving NHPs.
FAU - Prescott, M J
AU  - Prescott MJ
AD  - National Centre for the Replacement, Refinement and Reduction of Animals in
      Research (NC3Rs), 20 Park Crescent, London, W1B 1AL, UK.
LA  - eng
GR  - NC3RS001/NC3RS_/National Centre for the Replacement, Refinement and Reduction of 
      Animals in Research/United Kingdom
PT  - Journal Article
DEP - 20101112
PL  - Germany
TA  - Adv Sci Res
JT  - Advances in science and research
JID - 101777284
PMC - PMC7610564
MID - EMS119444
EDAT- 2010/11/01 00:00
MHDA- 2010/11/01 00:01
CRDT- 2021/04/12 06:19
PHST- 2021/04/12 06:19 [entrez]
PHST- 2010/11/01 00:00 [pubmed]
PHST- 2010/11/01 00:01 [medline]
AID - 10.5194/asr-5-11-2010 [doi]
PST - ppublish
SO  - Adv Sci Res. 2010 Nov;5(1):11-22. doi: 10.5194/asr-5-11-2010. Epub 2010 Nov 12.


PMID- 27026958
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160330
LR  - 20200930
IS  - 2255-4971 (Print)
IS  - 2255-4971 (Linking)
VI  - 45
IP  - 6
DP  - 2010 Nov-Dec
TI  - BONE BANKS.
PG  - 524-8
LID - 10.1016/S2255-4971(15)30297-4 [doi]
AB  - Bone banks are necessary for providing biological material for a series of
      orthopedic procedures. The growing need for musculoskeletal tissues for
      transplantation has been due to the development of new surgical techniques, and
      this has led to a situation in which a variety of hospital services have been
      willing to have their own source of tissue for transplantation. To increase the
      safety of transplanted tissues, standards for bone bank operation have been
      imposed by the government, which has limited the number of authorized
      institutions. The good performance in a bone bank depends on strict control over 
      all stages, including: formation of well-trained harvesting teams; donor
      selection; conducting various tests on the tissues obtained; and strict control
      over the processing techniques used. Combination of these factors enables greater
      scope of use and numbers of recipient patients, while the incidence of tissue
      contamination becomes statistically insignificant, and there is traceability
      between donors and recipients. This paper describes technical considerations
      relating to how a bone bank functions, the use of grafts and orthopedic
      applications, the ethical issues and the main obstacles encountered.
FAU - de Alencar, Paulo Gilberto Cimbalista
AU  - de Alencar PG
AD  - Head of the Hip and Knee Surgery Group, Hospital de Clinicas, Federal University 
      of Parana.
FAU - Vieira, Inacio Faco Ventura
AU  - Vieira IF
AD  - Orthopedist in the Hip and Knee Surgery Group, Hospital de Clinicas, Federal
      University of Parana.
LA  - eng
PT  - Journal Article
DEP - 20151116
PL  - Brazil
TA  - Rev Bras Ortop
JT  - Revista brasileira de ortopedia
JID - 101660959
PMC - PMC4799200
OTO - NOTNLM
OT  - Allograft
OT  - Bone Banks
OT  - Bone Transplantation
OT  - Orthopedic Surgery
EDAT- 2010/11/01 00:00
MHDA- 2010/11/01 00:01
CRDT- 2016/03/31 06:00
PHST- 2010/10/05 00:00 [received]
PHST- 2010/10/05 00:00 [accepted]
PHST- 2016/03/31 06:00 [entrez]
PHST- 2010/11/01 00:00 [pubmed]
PHST- 2010/11/01 00:01 [medline]
AID - 10.1016/S2255-4971(15)30297-4 [doi]
AID - S2255-4971(15)30297-4 [pii]
PST - epublish
SO  - Rev Bras Ortop. 2015 Nov 16;45(6):524-8. doi: 10.1016/S2255-4971(15)30297-4.
      eCollection 2010 Nov-Dec.


PMID- 26271776
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150815
LR  - 20180209
IS  - 1939-5078 (Print)
IS  - 1939-5078 (Linking)
VI  - 1
IP  - 6
DP  - 2010 Nov
TI  - Narrativity and non-Narrativity.
PG  - 775-780
LID - 10.1002/wcs.92 [doi]
AB  - I argue against two popular claims. The first is a descriptive, empirical claim
      about the nature of ordinary human experience which I call the psychological
      Narrativity thesis (PNT). According to PNT, 'each of us constructs and lives a
      "narrative" ... this narrative is us, our identities' (Sacks O. The Man Who
      Mistook His Wife for a Hat. London: Duckworth; 1985, 110). The second is a
      normative, ethical claim which I call the ethical Narrativity thesis (ENT).
      According to ENT, we ought to live our lives narratively, or as a story: a 'basic
      condition of making sense of ourselves is that we grasp our lives in a narrative'
      and have an understanding of our lives 'as an unfolding story' (Taylor C. Sources
      of the Self. Cambridge: Cambridge University Press; 1989, 47-52). On this view a 
      person 'creates his identity (only) by forming an autobiographical narrative-a
      story of his life', and must be in possession of a full and 'explicit narrative
      (of his life) to develop fully as a person' (Schechtman M. The Constitution of
      Selves. Ithaca, NY: Cornell University Press; 1996, 93. WIREs Cogn Sci 2010 1
      775-780 For further resources related to this article, please visit the WIREs
      website.
CI  - Copyright (c) 2010 John Wiley & Sons, Ltd.
FAU - Strawson, Galen
AU  - Strawson G
AD  - Department of Philosophy, School of Humanities, University of Reading, UK.
LA  - eng
PT  - Editorial
PL  - United States
TA  - Wiley Interdiscip Rev Cogn Sci
JT  - Wiley interdisciplinary reviews. Cognitive science
JID - 101524169
EDAT- 2010/11/01 00:00
MHDA- 2010/11/01 00:01
CRDT- 2015/08/15 06:00
PHST- 2015/08/15 06:00 [entrez]
PHST- 2010/11/01 00:00 [pubmed]
PHST- 2010/11/01 00:01 [medline]
AID - 10.1002/wcs.92 [doi]
PST - ppublish
SO  - Wiley Interdiscip Rev Cogn Sci. 2010 Nov;1(6):775-780. doi: 10.1002/wcs.92.


PMID- 23864762
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130718
LR  - 20211021
IS  - 0899-8299 (Print)
IS  - 0899-8299 (Linking)
VI  - 42
IP  - 3
DP  - 2010 Nov
TI  - The muslim physician and the ethics of medicine.
PG  - 111-6
LID - 10.5915/42-3-5403 [doi]
AB  - Virtuous physicians seem to have become a rarity in modern day medical practice. 
      Many patients and physicians feel that the profession of medicine is not living
      up to its own standards and expectations. It is the contention of the author that
      the Muslim physician, guided by the two primary sources of Islamic Law, the
      Qur'an and the Sunna, will possess the necessary character traits of a good
      physician. In this article I argue that the Muslim physician who abides by the
      Qur'an will live a contented life, will be trusted by his/her patients and
      community, and will be in line with the recently enacted Western principles of
      medical ethics.
FAU - Arawi, Thalia A
AU  - Arawi TA
AD  - Clinical Bioethicist and Founding Director, Salim El-Hoss Bioethics &
      Professionalism Program, American University of Beirut, Beirut, Lebanon.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J IMA
JT  - The Journal of IMA
JID - 8903928
PMC - PMC3708676
OTO - NOTNLM
OT  - Islam
OT  - Islamic medical ethics
OT  - Medical ethics
OT  - Qur'an
EDAT- 2010/11/01 00:00
MHDA- 2010/11/01 00:01
CRDT- 2013/07/19 06:00
PHST- 2013/07/19 06:00 [entrez]
PHST- 2010/11/01 00:00 [pubmed]
PHST- 2010/11/01 00:01 [medline]
AID - 10.5915/42-3-5403 [doi]
AID - jima-42-3-5403 [pii]
PST - ppublish
SO  - J IMA. 2010 Nov;42(3):111-6. doi: 10.5915/42-3-5403.


PMID- 23864761
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130718
LR  - 20211021
IS  - 0899-8299 (Print)
IS  - 0899-8299 (Linking)
VI  - 42
IP  - 3
DP  - 2010 Nov
TI  - Mental health issues of muslim americans.
PG  - 106-10
LID - 10.5915/42-3-5507 [doi]
AB  - The underpinning of all research leading to various schools of thought in the
      field of psychiatry and psychology is without doubt a product of Western
      professionals who represent the religio-cultural traditions, historical symbols, 
      and narratives of Western society. Also, the major schools of psychotherapy
      emerged during an era of individualism and logical positivism reflecting the
      religious, ethical, and cultural heritage that has shaped the modern Western
      society. Consequently, the methods and techniques developed in the West may not
      be always suitable and effective for Muslim Americans. To respond to the growing 
      needs of psychiatric problems encountered by Muslim Americans, many community
      social service centers have been established in the United States during the past
      two decades. We now have a growing body of research data suggesting how to tailor
      our field to the specific needs of this population. We will discuss what kind of 
      emotional and psychiatric problems are most prevalent in Muslim Americans and
      explain the therapeutic approaches mental health professionals have used and the 
      treatment strategies which have been found effective in the psychosocial
      rehabilitation of Muslim Americans.
FAU - Basit, Abdul
AU  - Basit A
AD  - Hamdard Center for Health and Human Services Chicago, Illinois.
FAU - Hamid, Mohammad
AU  - Hamid M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J IMA
JT  - The Journal of IMA
JID - 8903928
PMC - PMC3708677
OTO - NOTNLM
OT  - Mental health
OT  - Muslim Americans
OT  - cultural sensitivity
EDAT- 2010/11/01 00:00
MHDA- 2010/11/01 00:01
CRDT- 2013/07/19 06:00
PHST- 2013/07/19 06:00 [entrez]
PHST- 2010/11/01 00:00 [pubmed]
PHST- 2010/11/01 00:01 [medline]
AID - 10.5915/42-3-5507 [doi]
AID - jima-42-3-5507 [pii]
PST - ppublish
SO  - J IMA. 2010 Nov;42(3):106-10. doi: 10.5915/42-3-5507.


PMID- 23864760
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130718
LR  - 20211021
IS  - 0899-8299 (Print)
IS  - 0899-8299 (Linking)
VI  - 42
IP  - 3
DP  - 2010 Nov
TI  - The Bioethical Concept of Life for Life in Judaism, Catholicism, and Islam:
      Abortion When the Mother's Life is in Danger.
PG  - 99-105
LID - 10.5915/42-3-5351 [doi]
AB  - Modern secular bioethics has focused on developing a set of universal principles 
      to guide clinical decision making. However, this ignores the important role of
      religion in resolving bioethical questions. It is imperative that health-care
      providers understand these belief systems in order to traverse value conflicts
      and provide the highest quality care to a diverse population. This paper focuses 
      on the process of bioethical deliberation in Judaism, Catholicism, and Islam.
      Abortion is normatively prohibited in each faith and through examining how each
      ethical code allows for abortion when the mother's life is in peril due to the
      fetus, we highlight the value of unborn life in each faith. Orthodox Judaism uses
      the concept of rodef, or pursuer, to permit abortion in this scenario,
      Catholicism uses the moral concept of "double effect," while Islamic law cites
      the maqasid, higher objectives of the law, to permit abortion in this scenario.
FAU - Khorfan, Rhami
AU  - Khorfan R
AD  - Wayne State University School of Medicine.
FAU - Padela, Aasim I
AU  - Padela AI
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J IMA
JT  - The Journal of IMA
JID - 8903928
PMC - PMC3708674
OTO - NOTNLM
OT  - Bioethics
OT  - Catholicism
OT  - Islam
OT  - Judaism
OT  - abortion
EDAT- 2010/11/01 00:00
MHDA- 2010/11/01 00:01
CRDT- 2013/07/19 06:00
PHST- 2013/07/19 06:00 [entrez]
PHST- 2010/11/01 00:00 [pubmed]
PHST- 2010/11/01 00:01 [medline]
AID - 10.5915/42-3-5351 [doi]
AID - jima-42-3-5351 [pii]
PST - ppublish
SO  - J IMA. 2010 Nov;42(3):99-105. doi: 10.5915/42-3-5351.


PMID- 22937559
OWN - NLM
STAT- MEDLINE
DCOM- 20120917
LR  - 20190918
IS  - 1882-0654 (Electronic)
IS  - 0009-918X (Linking)
VI  - 50
IP  - 11
DP  - 2010 Nov
TI  - [Ethics in terminal care in the field of neurology].
PG  - 1025
FAU - Hagino, Mieko
AU  - Hagino M
FAU - Nishizawa, Masatomi
AU  - Nishizawa M
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Rinsho Shinkeigaku
JT  - Rinsho shinkeigaku = Clinical neurology
JID - 0417466
SB  - IM
MH  - Humans
MH  - Nervous System Diseases/*therapy
MH  - Neurology/*ethics
MH  - Surveys and Questionnaires
MH  - Terminal Care/*ethics
EDAT- 2010/11/01 00:00
MHDA- 2012/09/18 06:00
CRDT- 2012/09/04 06:00
PHST- 2012/09/04 06:00 [entrez]
PHST- 2010/11/01 00:00 [pubmed]
PHST- 2012/09/18 06:00 [medline]
AID - 10.5692/clinicalneurol.50.1025 [doi]
PST - ppublish
SO  - Rinsho Shinkeigaku. 2010 Nov;50(11):1025. doi: 10.5692/clinicalneurol.50.1025.


PMID- 21030475
OWN - NLM
STAT- MEDLINE
DCOM- 20110429
LR  - 20101214
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 1
DP  - 2011 Jan
TI  - Ethical and legal acceptability of the use of neuromuscular blockers (NMBs) in
      connection with abstention decisions in Dutch NICUs: interviews with
      neonatologists.
PG  - 29-33
LID - 10.1136/jme.2010.037267 [doi]
AB  - BACKGROUND: In the Netherlands, using drugs to deliberately end the life of a
      severely defective newborn baby who is in extreme suffering can be permissible
      under very precise circumstances. This does not mean that all Dutch
      neonatologists are willing to engage in such behaviour. This paper discusses the 
      use of neuromuscular blockers (NMBs) in connection with abstention decisions in
      neonatology and the boundaries between 'deliberate ending of life' and other
      end-of-life decisions. These boundaries are of paramount importance because, of
      all end-of-life decisions, only 'deliberate ending of life' must be reported by
      the responsible doctor and exposes him to the risk of being prosecuted. METHODS: 
      14 Dutch neonatologists were presented with a hypothetical case of a severely
      asphyxiated baby who faces a long dying process after withdrawal of 'medically
      futile' (zinloos) life-sustaining ventilation. Doctors were asked whether it is
      acceptable to administer NMBs in this situation and whether such behaviour should
      be reported. RESULTS AND CONCLUSIONS: Doctors' responses were heterogeneous,
      showing that the acceptability of using NMBs in certain situations and the
      boundaries between end-of-life decisions are currently a subject of discussion
      among Dutch neonatologists. Many respondents reported feeling threatened by the
      potential involvement of the criminal law authorities in the system of control
      over 'deliberate ending of life'.
FAU - Moratti, Sofia
AU  - Moratti S
AD  - University of Groningen, The Netherlands, P O Box 716, 9700 AS Groningen, The
      Netherlands. info@sofiamoratti.eu
LA  - eng
PT  - Journal Article
DEP - 20101028
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
RN  - 0 (Neuromuscular Blocking Agents)
SB  - IM
MH  - Attitude of Health Personnel
MH  - Decision Making/*ethics
MH  - Euthanasia/*ethics
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Newborn, Diseases/*drug therapy
MH  - Intensive Care Units, Neonatal
MH  - Medical Futility/ethics
MH  - Neonatology/*ethics
MH  - Netherlands
MH  - Neuromuscular Blocking Agents/*administration & dosage
MH  - Withholding Treatment/*ethics
EDAT- 2010/10/30 06:00
MHDA- 2011/04/30 06:00
CRDT- 2010/10/30 06:00
PHST- 2010/10/30 06:00 [entrez]
PHST- 2010/10/30 06:00 [pubmed]
PHST- 2011/04/30 06:00 [medline]
AID - jme.2010.037267 [pii]
AID - 10.1136/jme.2010.037267 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Jan;37(1):29-33. doi: 10.1136/jme.2010.037267. Epub 2010 Oct
      28.


PMID- 21030474
OWN - NLM
STAT- MEDLINE
DCOM- 20110315
LR  - 20151119
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 12
DP  - 2010 Dec
TI  - Medicine and the Holocaust: a visit to the Nazi death camps as a means of
      teaching medical ethics in the Israel Defense Forces Medical Corps.
PG  - 821-6
LID - 10.1136/jme.2010.037101 [doi]
AB  - A novel method of teaching military medical ethics, medical ethics and military
      ethics in the Israel Defense Force (IDF) Medical Corps, essential topics for all 
      military medical personnel, is discussed. Very little time is devoted to medical 
      ethics in medical curricula, and even less to military medical ethics.
      Ninety-five per cent of American students in eight medical schools had less than 
      1&emsp14;h of military medical ethics teaching and few knew the basic tenets of
      the Geneva Convention. Medical ethics differs from military medical ethics: the
      former deals with the relationship between medical professional and patient,
      while in the latter military physicians have to balance between military
      necessity and their traditional priorities to their patients. The underlying
      principles, however, are the same in both: the right to life, autonomy, dignity
      and utility. The IDF maintains high moral and ethical standards. This stems from 
      the preciousness of human life in Jewish history, tradition and religious law.
      Emphasis is placed on these qualities within the Israeli education system; the
      IDF teaches and enforces moral and ethical standards in all of its training
      programmes and units. One such programme is 'Witnesses in Uniform' in which the
      IDF takes groups of officers to visit Holocaust memorial sites and Nazi death
      camps. During these visits daily discussions touch on intricate medical and
      military ethical issues, and contemporary ethical dilemmas relevant to IDF
      officers during active missions.
FAU - Oberman, Anthony S
AU  - Oberman AS
AD  - The Medical Center, Ashdod, Israel. anthonyo@doctors.org.uk
FAU - Brosh-Nissimov, Tal
AU  - Brosh-Nissimov T
FAU - Ash, Nachman
AU  - Ash N
LA  - eng
PT  - Journal Article
DEP - 20101028
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Adult
MH  - *Concentration Camps
MH  - Education, Medical/*methods
MH  - Ethics, Medical/*education
MH  - Female
MH  - Human Experimentation/ethics
MH  - Humans
MH  - Israel
MH  - Male
MH  - Middle Aged
MH  - *Military Medicine
MH  - Retrospective Studies
MH  - Surveys and Questionnaires
MH  - Teaching/methods
MH  - Young Adult
EDAT- 2010/10/30 06:00
MHDA- 2011/03/16 06:00
CRDT- 2010/10/30 06:00
PHST- 2010/10/30 06:00 [entrez]
PHST- 2010/10/30 06:00 [pubmed]
PHST- 2011/03/16 06:00 [medline]
AID - jme.2010.037101 [pii]
AID - 10.1136/jme.2010.037101 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Dec;36(12):821-6. doi: 10.1136/jme.2010.037101. Epub 2010 Oct 
      28.


PMID- 21030473
OWN - NLM
STAT- MEDLINE
DCOM- 20110315
LR  - 20101129
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 12
DP  - 2010 Dec
TI  - The transformation of (bio)ethics expertise in a world of ethical pluralism.
PG  - 767-70
LID - 10.1136/jme.2010.036319 [doi]
AB  - Today, bioethics experts have an increasing role in public life. However, the
      question arises: what does bioethics expertise really mean? Can there be such a
      thing in our globalised world characterised by ethical pluralism? I will argue
      that bioethics as a discipline represents the transformation of ethics expertise 
      from a hard to a soft form of it. Bioethics was born as a reaction to the growing
      awareness of ethical pluralism, and it denied the hard form of
      normative-prescriptive ethics expertise (the ability to determine what is the
      right course of action for others), particularly in its medical ethics form. In
      contrast, the traditional medical ethics model, and pre-modern societies in
      general, believed in hard normative ethics expertise. From this followed the
      characteristic paternalism of traditional medical practice: if physicians were
      experts in moral matters as well, if they knew what the right course of action to
      choose was, then they had a right to benevolently force this course of action on 
      their patients. The remnants of this doctrine, although rarely stated explicitly,
      still can often be seen in clinical practice. The whole bioethics movement can be
      seen as a radical denial of the doctrine of physician's hard expertise in moral
      matters. Bioethics, however, represents a type of soft ethics expertise (mainly
      value sensitivity). Hence follows the seeming paradox of bioethics expertise:
      bioethics is both a denial of ethics expertise (in its hard form) as well as a
      type of (soft) ethics expertise.
FAU - Kovacs, Jozsef
AU  - Kovacs J
AD  - Department of Bioethics, Institute of Behavioural Sciences, Semmelweis
      University, Budapest, PO Box 370, Hungary. kovjozs@net.sote.hu
LA  - eng
PT  - Journal Article
DEP - 20101028
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Bioethics
MH  - *Cultural Diversity
MH  - Ethical Analysis
MH  - *Ethics, Medical
MH  - Humans
MH  - Morals
MH  - Philosophy
MH  - *Professional Competence
EDAT- 2010/10/30 06:00
MHDA- 2011/03/16 06:00
CRDT- 2010/10/30 06:00
PHST- 2010/10/30 06:00 [entrez]
PHST- 2010/10/30 06:00 [pubmed]
PHST- 2011/03/16 06:00 [medline]
AID - jme.2010.036319 [pii]
AID - 10.1136/jme.2010.036319 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Dec;36(12):767-70. doi: 10.1136/jme.2010.036319. Epub 2010 Oct
      28.


PMID- 21029941
OWN - NLM
STAT- MEDLINE
DCOM- 20110210
LR  - 20161021
IS  - 0219-3108 (Electronic)
IS  - 1015-9584 (Linking)
VI  - 33
IP  - 2
DP  - 2010 Apr
TI  - Strategies for widening liver donor pool.
PG  - 63-9
LID - 10.1016/S1015-9584(10)60011-5 [doi]
AB  - Liver transplantation is a life-saving treatment modality, but is hindered by the
      scarcity of deceased-donor liver grafts. To acquire more liver grafts and thus
      save more lives, various techniques have been devised and policies adopted,
      including living-donor, split-graft and sequential liver transplantation;
      extended donor criteria; and donation after cardiac death. However, with these
      techniques and policies come a range of entailed medical concerns and concomitant
      ethical dilemmas, mainly bearing on the welfare of donors and potential donors.
      In this article, we provide an overview of how the transplant community works
      towards the end of extending the liver donor pool, with the aim of ensuring that 
      more liver transplant candidates receive their transplant as early as possible.
      The current strategies in Hong Kong in this regard are also reviewed.
CI  - Copyright (c) 2010 Asian Surgical Association. Published by Elsevier B.V. All
      rights reserved.
FAU - Chung, Ho Yu
AU  - Chung HY
AD  - Department of Surgery, The University of Hong Kong, Hong Kong SAR, China.
FAU - Chan, See Ching
AU  - Chan SC
FAU - Lo, Chung Mau
AU  - Lo CM
FAU - Fan, Sheung Tat
AU  - Fan ST
LA  - eng
PT  - Journal Article
PT  - Review
PL  - China
TA  - Asian J Surg
JT  - Asian journal of surgery
JID - 8900600
SB  - IM
MH  - Death
MH  - Hong Kong
MH  - Humans
MH  - *Liver Transplantation/adverse effects/ethics/methods/mortality/statistics &
      numerical data
MH  - *Tissue and Organ Procurement/ethics
EDAT- 2010/10/30 06:00
MHDA- 2011/02/11 06:00
CRDT- 2010/10/30 06:00
PHST- 2010/08/04 00:00 [accepted]
PHST- 2010/10/30 06:00 [entrez]
PHST- 2010/10/30 06:00 [pubmed]
PHST- 2011/02/11 06:00 [medline]
AID - S1015-9584(10)60011-5 [pii]
AID - 10.1016/S1015-9584(10)60011-5 [doi]
PST - ppublish
SO  - Asian J Surg. 2010 Apr;33(2):63-9. doi: 10.1016/S1015-9584(10)60011-5.


PMID- 21029709
OWN - NLM
STAT- MEDLINE
DCOM- 20110510
LR  - 20101029
IS  - 0255-7053 (Print)
IS  - 0255-7053 (Linking)
VI  - 40
IP  - 3
DP  - 2010 May
TI  - [Analysis on the background of arising of Evidence-based medicine].
PG  - 149-54
AB  - Science is coming from the background of social culture. Evidence-based medicine 
      (EBM) was generated at the early 90's of 20th Century, and there were some
      landmark things before its appearance. The background of EBM included: (1) risk
      control of medical techniques at the 70s of 20th Century; (2) ethical ideas of
      Protestant, including secularism, rationalism and utilitarianism; (3) British
      positivism and its tradition.
FAU - Xie, Yu
AU  - Xie Y
AD  - China Center for Evidence-Based Medicine, Sichuan University, Chengdu 610041,
      China.
FAU - Ai, Chang-lin
AU  - Ai CL
FAU - Deng, Shao-lin
AU  - Deng SL
FAU - Li, You-ping
AU  - Li YP
LA  - chi
PT  - English Abstract
PT  - Historical Article
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Shi Za Zhi
JT  - Zhonghua yi shi za zhi (Beijing, China : 1980)
JID - 8303081
MH  - Evidence-Based Medicine/*history
MH  - History, 20th Century
MH  - Humans
EDAT- 2010/10/30 06:00
MHDA- 2011/05/11 06:00
CRDT- 2010/10/30 06:00
PHST- 2010/10/30 06:00 [entrez]
PHST- 2010/10/30 06:00 [pubmed]
PHST- 2011/05/11 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Shi Za Zhi. 2010 May;40(3):149-54.


PMID- 21029285
OWN - NLM
STAT- MEDLINE
DCOM- 20110907
LR  - 20220331
IS  - 1369-7625 (Electronic)
IS  - 1369-6513 (Linking)
VI  - 14
IP  - 2
DP  - 2011 Jun
TI  - A relational perspective on autonomy for older adults residing in nursing homes.
PG  - 182-90
LID - 10.1111/j.1369-7625.2010.00638.x [doi]
AB  - AIM: To review critically the traditional concept of autonomy, propose an
      alternative relational interpretation of autonomy, and discuss how this would
      operate in identifying and addressing ethical issues that arise in the context of
      nursing home care for older adults. BACKGROUND: Respect for patient autonomy has 
      been the cornerstone of clinical bioethics for several decades. Important though 
      this principle is, there is debate on how to interpret the core concept of
      autonomy. We review the appeal of the traditional approach to autonomy in health 
      care and then identify some of the difficulties with this conception. METHODS: We
      use philosophical methods to explain and discuss the traditional and relational
      conceptions of autonomy and we illuminate our discussion with examples of various
      contextual applications. CONCLUSION: We support the relational conception of
      autonomy as offering a richer, more contextualized understanding of autonomy
      which attends to the social, political and economic conditions that serve as
      background to an agent's deliberations. To illuminate these ideas, we discuss the
      situation of frail older adults who frequently find their autonomy limited not
      only by their medical conditions but also by cultural prejudices against the aged
      and by the conditions commonly found within the nursing homes in which many
      reside. We propose ways of improving the relational autonomy of this population.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Sherwin, Susan
AU  - Sherwin S
AD  - Department of Philosophy, Dalhousie University, Halifax, NS, Canada.
      ssherwin@dal.ca
FAU - Winsby, Meghan
AU  - Winsby M
LA  - eng
PT  - Comment
PT  - Journal Article
DEP - 20101028
PL  - England
TA  - Health Expect
JT  - Health expectations : an international journal of public participation in health 
      care and health policy
JID - 9815926
SB  - IM
CON - Health Expect. 2011 Jun;14(2):178-81. PMID: 21592263
MH  - Aged
MH  - Aging/*psychology
MH  - Decision Making
MH  - Homes for the Aged
MH  - Humans
MH  - Mental Competency
MH  - Nursing Homes
MH  - *Patient Rights/ethics
MH  - *Personal Autonomy
MH  - Philosophy, Medical
MH  - Social Justice
PMC - PMC5060573
EDAT- 2010/10/30 06:00
MHDA- 2011/09/08 06:00
CRDT- 2010/10/30 06:00
PHST- 2010/10/30 06:00 [entrez]
PHST- 2010/10/30 06:00 [pubmed]
PHST- 2011/09/08 06:00 [medline]
AID - 10.1111/j.1369-7625.2010.00638.x [doi]
PST - ppublish
SO  - Health Expect. 2011 Jun;14(2):182-90. doi: 10.1111/j.1369-7625.2010.00638.x. Epub
      2010 Oct 28.


PMID- 21029223
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20110727
IS  - 1365-2354 (Electronic)
IS  - 0961-5423 (Linking)
VI  - 20
IP  - 5
DP  - 2011 Sep
TI  - Disclosing information about randomised controlled trials in oncology: training
      concept and evaluation of an individualised communication skills training for
      physicians COM-ON-rct.
PG  - 570-6
LID - 10.1111/j.1365-2354.2010.01233.x [doi]
AB  - When physicians disclose information about randomised controlled trials, they
      have to balance the requirements of conducting high standard research and the
      respect for patients' rights. Physicians need training in this difficult matter. 
      An individualised communication skills training (CST) about randomised controlled
      trials for oncologists has been developed. The aim of this publication is to
      describe the concept of our CST and present data of evaluation by the
      participants: First, a theoretical introduction about a communication model and
      important ethical and legal issues was presented. Individual learning goals of
      participants were then derived through video assessment with actor-patients. The 
      learning goals were the basis for practicing in role play. Individual coaching
      helped physicians to transfer the made experience into their daily work. Forty
      physicians have been trained. The acceptance of the training concept was assessed
      by a questionnaire consisting of 14 items and using a 6-point scale from 1 (very 
      best) to 6 (very bad): the individualised CST was highly accepted (mean = 1.33). 
      Practicing with actor-patients (mean = 1.4), providing constructive feedback
      (mean = 1.3) and assessing individual learning goals (mean = 1.85) were seen as
      helpful. Our CST trains physicians to realise best research standards and
      incorporate patients' rights.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Wuensch, A
AU  - Wuensch A
AD  - Department of Psychosomatic Medicine and Psychotherapy, University Hospital
      Freiburg, Freiburg, Germany. alexander.wuensch@uniklinik-freiburg.de
FAU - Goelz, T
AU  - Goelz T
FAU - Bertz, H
AU  - Bertz H
FAU - Wirsching, M
AU  - Wirsching M
FAU - Fritzsche, K
AU  - Fritzsche K
LA  - eng
PT  - Journal Article
DEP - 20101005
PL  - England
TA  - Eur J Cancer Care (Engl)
JT  - European journal of cancer care
JID - 9301979
MH  - Adult
MH  - Clinical Competence
MH  - *Communication
MH  - Disclosure
MH  - Education, Medical, Continuing/methods
MH  - Female
MH  - Humans
MH  - *Inservice Training
MH  - Male
MH  - Middle Aged
MH  - *Neoplasms/therapy
MH  - Patient Rights
MH  - *Randomized Controlled Trials as Topic
MH  - Teaching/methods
EDAT- 2010/10/30 06:00
MHDA- 2011/10/25 06:00
CRDT- 2010/10/30 06:00
PHST- 2010/10/30 06:00 [entrez]
PHST- 2010/10/30 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
AID - 10.1111/j.1365-2354.2010.01233.x [doi]
PST - ppublish
SO  - Eur J Cancer Care (Engl). 2011 Sep;20(5):570-6. doi:
      10.1111/j.1365-2354.2010.01233.x. Epub 2010 Oct 5.


PMID- 20981592
OWN - NLM
STAT- MEDLINE
DCOM- 20110414
LR  - 20211020
IS  - 1615-6722 (Electronic)
IS  - 0723-5003 (Linking)
VI  - 105
IP  - 10
DP  - 2010 Oct
TI  - [Evaluation of preventive measures using scientific methods].
PG  - 724-9
LID - 10.1007/s00063-010-1104-9 [doi]
AB  - The evaluation of preventive and health activities is due to ethical and
      financial aspects increasingly gaining importance. But how can this be assured on
      a scientifically high level? A tool that suits this purpose is Health Technology 
      Assessment (HTA). Provided that the appropriate methodology is selected and
      scientific literature is evaluated, HTA can help to appraise the outcomes of
      preventive activities. The German Institute of Medical Documentation and
      Information publishes HTA reports on behalf of the Federal Health Ministry. These
      deal with topics related to prevention amongst others. Examples of the year 2009 
      are reports on the vaccination against human papilloma virus or on the
      nonmedicinal secondary prevention of coronary heart disease.
FAU - Gohlen, Britta
AU  - Gohlen B
AD  - Deutsche Agentur fur Health Technology Assessment, Deutschen Instituts fur
      Medizinische Dokumentation und Information, Waisenhausgasse 36-38a, Koln,
      Germany. britta.goehlen@dimdi.de
FAU - Bossmann, Hildegard
AU  - Bossmann H
LA  - ger
PT  - Journal Article
TT  - Bewertung praventiver Massnahmen mit wissenschaftlichen Methode.
DEP - 20101028
PL  - Germany
TA  - Med Klin (Munich)
JT  - Medizinische Klinik (Munich, Germany : 1983)
JID - 8303501
SB  - IM
MH  - Biomedical Technology/*standards
MH  - Germany
MH  - Health Promotion/standards
MH  - Humans
MH  - National Health Programs/*standards
MH  - Outcome and Process Assessment, Health Care/*standards
MH  - Preventive Health Services/*standards
MH  - Quality Indicators, Health Care/standards
MH  - Technology Assessment, Biomedical/*standards
EDAT- 2010/10/29 06:00
MHDA- 2011/04/16 06:00
CRDT- 2010/10/29 06:00
PHST- 2010/05/14 00:00 [received]
PHST- 2010/07/15 00:00 [accepted]
PHST- 2010/10/29 06:00 [entrez]
PHST- 2010/10/29 06:00 [pubmed]
PHST- 2011/04/16 06:00 [medline]
AID - 10.1007/s00063-010-1104-9 [doi]
PST - ppublish
SO  - Med Klin (Munich). 2010 Oct;105(10):724-9. doi: 10.1007/s00063-010-1104-9. Epub
      2010 Oct 28.


PMID- 20981506
OWN - NLM
STAT- MEDLINE
DCOM- 20110701
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 16
IP  - 4
DP  - 2010 Dec
TI  - Editors' overview: topics in the responsible management of research data.
PG  - 631-7
LID - 10.1007/s11948-010-9243-1 [doi]
AB  - Responsible data management is a multifaceted topic involving standards within
      the research community regarding research design and the sharing of data as well 
      as the collection, selection, analysis and interpretation of data. Transparency
      in the manipulation of images is increasingly important in order to avoid
      misrepresentation of research findings, and research oversight is also critical
      in helping to assure the integrity of the research process. Intellectual property
      issues both unite and divide academe and industry in their approaches to data
      management. Central to the realization and promulgation of responsible data
      management is clear and careful communication of standards and expectations
      within the research community to trainees as well as among colleagues. These
      topics are examined and explored in depth in a special issue of Science and
      Engineering Ethics on responsible data management.
FAU - Giffels, Joe
AU  - Giffels J
FAU - Vollmer, Sara H
AU  - Vollmer SH
FAU - Bird, Stephanie J
AU  - Bird SJ
LA  - eng
PT  - Editorial
DEP - 20101028
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Data Interpretation, Statistical
MH  - *Ethics, Research
MH  - *Information Management
MH  - Intellectual Property
MH  - Research Design/*standards
MH  - Scientific Misconduct
EDAT- 2010/10/29 06:00
MHDA- 2011/07/02 06:00
CRDT- 2010/10/29 06:00
PHST- 2010/07/06 00:00 [received]
PHST- 2010/10/07 00:00 [accepted]
PHST- 2010/10/29 06:00 [entrez]
PHST- 2010/10/29 06:00 [pubmed]
PHST- 2011/07/02 06:00 [medline]
AID - 10.1007/s11948-010-9243-1 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2010 Dec;16(4):631-7. doi: 10.1007/s11948-010-9243-1. Epub 2010
      Oct 28.


PMID- 20981495
OWN - NLM
STAT- MEDLINE
DCOM- 20110519
LR  - 20110111
IS  - 1534-4681 (Electronic)
IS  - 1068-9265 (Linking)
VI  - 18
IP  - 1
DP  - 2011 Jan
TI  - Single-incision transumbilical laparo-endoscopic gastric benign tumor resection.
PG  - 191
LID - 10.1245/s10434-010-1349-9 [doi]
AB  - INTRODUCTION: The authors report resection of a gastric benign tumor through
      single-incision laparoscopy, guided by peroperative gastroscopy. VIDEO: A
      25-year-old man consulted after diagnosis of a 40 x 20 cm(2) endoluminal lesion
      of the gastric cardia. Preoperative work-up showed a stromal tumor with invasion 
      of the muscular layer. The umbilical scar was incised and, after placement of a
      purse-string suture, an 11-mm nondisposable trocar was inserted for a 10-mm 30
      degrees angled scope. Curved and reusable instruments (Karl Storz-Endoskope,
      Tuttlingen, Germany) and straight ultrasonic shears (Ethicon Endosurgery,
      Cincinnati, OH, US) were inserted transumbilically. Peroperative gastroscopy
      located the lesion on the smaller gastric curvature, 1 cm from the
      gastroesophageal junction. A stitch was placed in the center of the lesion, and
      gastroscopic grasper helped in maintaining the limits of resection. Gastrostomy
      was closed using two converting absorbable running sutures. Because of the curves
      of the instruments there was no conflict between the instruments' tips inside the
      abdomen (Fig. 1a), or between the surgeon's hands outside the abdomen (Fig. 1b). 
      Leak test with the gastroscope checked the integrity of the suture. The specimen 
      was retrieved transumbilically in a plastic bag. RESULTS: Operative time was 150 
      min, and the umbilical incision was less than 15 mm. The patient was discharged
      after 5 days, and he is doing well 3 months postoperatively. CONCLUSIONS:
      Laparoscopic gastric resection can be safely performed through a single-access.
      Peroperative gastroscopy permits the limits of resection to be precisely
      determine, and use of curved and reusable instruments allows surgeon to achieve
      ergonomic conditions as in classic laparoscopy, without increasing the
      laparoscopic cost.
FAU - Dapri, Giovanni
AU  - Dapri G
AD  - Department of Gastrointestinal Surgery, European School of Laparoscopic Surgery, 
      Saint-Pierre University Hospital, Brussels, Belgium. giovanni@dapri.net
FAU - Ntounda, Ruffin
AU  - Ntounda R
FAU - Himpens, Jacques
AU  - Himpens J
FAU - Carnevali, Pietro
AU  - Carnevali P
FAU - Scomersi, Serena
AU  - Scomersi S
FAU - Cadiere, Guy-Bernard
AU  - Cadiere GB
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20101028
PL  - United States
TA  - Ann Surg Oncol
JT  - Annals of surgical oncology
JID - 9420840
SB  - IM
MH  - Adult
MH  - *Gastrectomy
MH  - *Gastroscopy
MH  - Humans
MH  - *Laparoscopy
MH  - Male
MH  - Stomach Neoplasms/*pathology/*surgery
EDAT- 2010/10/29 06:00
MHDA- 2011/05/20 06:00
CRDT- 2010/10/29 06:00
PHST- 2010/07/31 00:00 [received]
PHST- 2010/10/29 06:00 [entrez]
PHST- 2010/10/29 06:00 [pubmed]
PHST- 2011/05/20 06:00 [medline]
AID - 10.1245/s10434-010-1349-9 [doi]
PST - ppublish
SO  - Ann Surg Oncol. 2011 Jan;18(1):191. doi: 10.1245/s10434-010-1349-9. Epub 2010 Oct
      28.


PMID- 20981291
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20220317
IS  - 1687-9856 (Electronic)
IS  - 1687-9848 (Linking)
VI  - 2010
DP  - 2010
TI  - Consensus in Guidelines for Evaluation of DSD by the Texas Children's Hospital
      Multidisciplinary Gender Medicine Team.
PG  - 919707
LID - 10.1155/2010/919707 [doi]
AB  - The Gender Medicine Team (GMT), comprised of members with expertise in
      endocrinology, ethics, genetics, gynecology, pediatric surgery, psychology, and
      urology, at Texas Children's Hospital and Baylor College of Medicine formed a
      task force to formulate a consensus statement on practice guidelines for managing
      disorders of sexual differentiation (DSD) and for making sex assignments. The GMT
      task force reviewed published evidence and incorporated findings from clinical
      experience. Grading of Recommendations, Assessment, Development, and Evaluation
      (GRADE) was used to assess the quality of evidence presented in the literature
      for establishing evidence-based guidelines. The task force presents a consensus
      statement regarding specific diagnostic and therapeutic issues in the management 
      of individuals who present with DSD. The consensus statement includes
      recommendations for (1) laboratory workup, (2) acute management, (3) sex
      assignment in an ethical framework that includes education and involvement of the
      parents, and (4) surgical management.
FAU - Douglas, Ganka
AU  - Douglas G
AD  - Department of Molecular and Human Genetics, Baylor College of Medicine, Texas
      Children's Hospital, Houston, TX 77030, USA.
FAU - Axelrad, Marni E
AU  - Axelrad ME
FAU - Brandt, Mary L
AU  - Brandt ML
FAU - Crabtree, Elizabeth
AU  - Crabtree E
FAU - Dietrich, Jennifer E
AU  - Dietrich JE
FAU - French, Shannon
AU  - French S
FAU - Gunn, Sheila
AU  - Gunn S
FAU - Karaviti, Lefkothea
AU  - Karaviti L
FAU - Lopez, Monica E
AU  - Lopez ME
FAU - Macias, Charles G
AU  - Macias CG
FAU - McCullough, Laurence B
AU  - McCullough LB
FAU - Suresh, Deepa
AU  - Suresh D
FAU - Sutton, V Reid
AU  - Sutton VR
LA  - eng
PT  - Journal Article
DEP - 20101017
PL  - England
TA  - Int J Pediatr Endocrinol
JT  - International journal of pediatric endocrinology
JID - 101516111
PMC - PMC2963131
EDAT- 2010/10/29 06:00
MHDA- 2010/10/29 06:01
CRDT- 2010/10/29 06:00
PHST- 2010/05/25 00:00 [received]
PHST- 2010/08/04 00:00 [revised]
PHST- 2010/08/09 00:00 [accepted]
PHST- 2010/10/29 06:00 [entrez]
PHST- 2010/10/29 06:00 [pubmed]
PHST- 2010/10/29 06:01 [medline]
AID - 10.1155/2010/919707 [doi]
PST - ppublish
SO  - Int J Pediatr Endocrinol. 2010;2010:919707. doi: 10.1155/2010/919707. Epub 2010
      Oct 17.


PMID- 20981242
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 0100-5502 (Print)
IS  - 0100-5502 (Linking)
VI  - 34
IP  - 1
DP  - 2010 Jan 1
TI  - [Ethical Attitudes of Brazilian Medical Students and Graduates with Active
      Methodologies.]
PG  - 43-56
AB  - The objective of this study was to conduct a diagnosis of the comprehensive
      inclusion of ethics in Brazilian medical training with a problem-based learning
      methodology and to describe students' and graduates' perceptions of ethical
      attitudes. The methodological design was a descriptive and documental case study 
      with a qualitative and quantitative approach. The sample consisted of 20 students
      per course year, totaling 120 students and 40 alumni from two graduating classes 
      at the ESCS School of Medicine. The project was approved by the Institutional
      Review Board of the State Health Secretariat, Federal District, Brazil. ESCS
      students and graduates showed that they approach ethical conflicts and respect
      for patients. However, an analysis of ethical sensitivity revealed weak
      perceptions and inappropriate attitudes by medical students, especially in the
      early years of medical school, requiring more systematic discussions on ethical
      and bioethical aspects integrated with practical activities, in order to increase
      and strengthen ethical reflection by students.
FAU - Novaes, Maria Rita Carvalho Garbi
AU  - Novaes MR
AD  - Escola Superior de Ciencias da Saude, Brasilia, DF, Brasil.
FAU - Novaes, Luiz Carlos Garcez
AU  - Novaes LC
FAU - Guilhem, Dirce
AU  - Guilhem D
FAU - Stepke, Fernando Lolas
AU  - Stepke FL
FAU - Silveira, Carla Cristina Costa
AU  - Silveira CC
FAU - Komatsu, Ricardo Shoiti
AU  - Komatsu RS
FAU - Trindade, Eliane Mendonca Vilar
AU  - Trindade EM
FAU - Guiotti, Murilo Galvao
AU  - Guiotti MG
LA  - spa
GR  - R25 TW006056/TW/FIC NIH HHS/United States
GR  - R25 TW006056-07/TW/FIC NIH HHS/United States
PT  - Journal Article
TT  - Actitudes Eticas de los estudiantes y egresados en carrera de medicina con
      metodologias activas.
PL  - Brazil
TA  - Rev Bras Educ Med
JT  - Revista brasileira de educacao medica
JID - 7810148
PMC - PMC2963432
MID - NIHMS221987
EDAT- 2010/10/29 06:00
MHDA- 2010/10/29 06:01
CRDT- 2010/10/29 06:00
PHST- 2010/10/29 06:00 [entrez]
PHST- 2010/10/29 06:00 [pubmed]
PHST- 2010/10/29 06:01 [medline]
AID - 10.1590/s0100-55022010000100006 [doi]
PST - ppublish
SO  - Rev Bras Educ Med. 2010 Jan 1;34(1):43-56. doi: 10.1590/s0100-55022010000100006.


PMID- 20981002
OWN - NLM
STAT- MEDLINE
DCOM- 20101214
LR  - 20211020
IS  - 1532-6535 (Electronic)
IS  - 0009-9236 (Linking)
VI  - 88
IP  - 6
DP  - 2010 Dec
TI  - Breaking barriers in the genomics and pharmacogenetics of drug addiction.
PG  - 779-91
LID - 10.1038/clpt.2010.175 [doi]
AB  - Drug addiction remains a substantial health issue with limited treatment options 
      currently available. Despite considerable advances in the understanding of human 
      genetic architecture, the genetic underpinning of complex disorders remains
      elusive. On the basis of our current understanding of neurobiology, numerous
      candidate genes have been implicated in the etiology and response to treatment
      for different addictions. Genome-wide association (GWA) studies have also
      identified novel targets. However, replication of these studies is often lacking,
      and this complicates interpretation. The situation is expected to improve as
      issues such as phenotypic characterization, the apparent "missing heritability," 
      the identification of functional variants, and possible gene-environment (G x E) 
      interactions are addressed. In addition, there is growing evidence that genetic
      information can be useful in refining the choice of addiction treatment. As
      genetic testing becomes more common in the practice of medicine, a variety of
      ethical and practical challenges, some of which are unique to drug addiction,
      will also need to be considered.
FAU - Ho, M K
AU  - Ho MK
AD  - Centre for Addiction & Mental Health, Department of Psychiatry, Pharmacology and 
      Toxicology, University of Toronto, Toronto, Ontario, Canada.
FAU - Goldman, D
AU  - Goldman D
FAU - Heinz, A
AU  - Heinz A
FAU - Kaprio, J
AU  - Kaprio J
FAU - Kreek, M J
AU  - Kreek MJ
FAU - Li, M D
AU  - Li MD
FAU - Munafo, M R
AU  - Munafo MR
FAU - Tyndale, R F
AU  - Tyndale RF
LA  - eng
GR  - R01 MH076537/MH/NIMH NIH HHS/United States
GR  - R01 MH079880/MH/NIMH NIH HHS/United States
GR  - P60 DA005130/DA/NIDA NIH HHS/United States
GR  - Z01 AA000280-18/Intramural NIH HHS/United States
GR  - R56 DA012854/DA/NIDA NIH HHS/United States
GR  - DA012854/DA/NIDA NIH HHS/United States
GR  - UL1 RR024143/RR/NCRR NIH HHS/United States
GR  - MOP86471/CAPMC/ CIHR/Canada
GR  - R01 DA012844/DA/NIDA NIH HHS/United States
GR  - DA013783/DA/NIDA NIH HHS/United States
GR  - DA 0220830/DA/NIDA NIH HHS/United States
GR  - DA012844/DA/NIDA NIH HHS/United States
GR  - R01 DA013783/DA/NIDA NIH HHS/United States
GR  - U01 DA020830/DA/NIDA NIH HHS/United States
GR  - R21 MH097639/MH/NIMH NIH HHS/United States
GR  - R01 DA012854/DA/NIDA NIH HHS/United States
GR  - P60-DA005130/DA/NIDA NIH HHS/United States
GR  - R01-MH79880/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20101027
PL  - United States
TA  - Clin Pharmacol Ther
JT  - Clinical pharmacology and therapeutics
JID - 0372741
RN  - 5S6W795CQM (Naltrexone)
RN  - UC6VBE7V1Z (Methadone)
SB  - IM
MH  - Genetic Testing/methods/trends
MH  - Genetic Variation/genetics
MH  - Genomics/*methods/trends
MH  - Humans
MH  - Methadone/therapeutic use
MH  - Naltrexone/therapeutic use
MH  - Pharmacogenetics/*methods/trends
MH  - Substance-Related Disorders/diagnosis/*drug therapy/*genetics
PMC - PMC3738009
MID - NIHMS496670
EDAT- 2010/10/29 06:00
MHDA- 2010/12/16 06:00
CRDT- 2010/10/29 06:00
PHST- 2010/10/29 06:00 [entrez]
PHST- 2010/10/29 06:00 [pubmed]
PHST- 2010/12/16 06:00 [medline]
AID - clpt2010175 [pii]
AID - 10.1038/clpt.2010.175 [doi]
PST - ppublish
SO  - Clin Pharmacol Ther. 2010 Dec;88(6):779-91. doi: 10.1038/clpt.2010.175. Epub 2010
      Oct 27.


PMID- 20980858
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20101028
IS  - 1938-808X (Electronic)
IS  - 1040-2446 (Linking)
VI  - 85
IP  - 11
DP  - 2010 Nov
TI  - Return-of-service programs: meeting community and student needs in an ethical
      manner.
PG  - 1681
LID - 10.1097/ACM.0b013e3181f5933d [doi]
FAU - Shoucri, Rami
AU  - Shoucri R
AD  - University of Toronto, Faculty of Medicine, Toronto, Ontario, Canada.
FAU - Hanson, Mark D
AU  - Hanson MD
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Acad Med
JT  - Academic medicine : journal of the Association of American Medical Colleges
JID - 8904605
SB  - IM
MH  - Canada
MH  - Education, Medical/*economics
MH  - *Ethics, Professional
MH  - Financing, Government
MH  - Humans
MH  - Models, Educational
MH  - *Training Support
MH  - United States
EDAT- 2010/10/29 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/10/29 06:00
PHST- 2010/10/29 06:00 [entrez]
PHST- 2010/10/29 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1097/ACM.0b013e3181f5933d [doi]
AID - 00001888-201011000-00021 [pii]
PST - ppublish
SO  - Acad Med. 2010 Nov;85(11):1681. doi: 10.1097/ACM.0b013e3181f5933d.


PMID- 20980850
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20101028
IS  - 1938-808X (Electronic)
IS  - 1040-2446 (Linking)
VI  - 85
IP  - 11
DP  - 2010 Nov
TI  - Commentary: Are we ready to embrace the rest of the Flexner Report?
PG  - 1669-71
LID - 10.1097/ACM.0b013e3181f5ced4 [doi]
AB  - At the start of the 20th century, Abraham Flexner proposed a number of reforms
      for medical education in his seminal 1910 report, Medical Education in the United
      States and Canada. His recommendations were wide ranging, including a strong
      scientific basis, use of pedagogical methods, and faculty whose principal role is
      that of educator. Of these, reforms in science education for medicine received
      the widest attention and revolutionized physicians' intellectual foundations for 
      medical practice. But what of Flexner's other suggested reforms, those skills
      needed to develop "the educated man" who can meet the "greatly modified ethical
      responsibility" of modern medical practice? As the 21st century begins, Flexner's
      ideas on these other subjects he considered critical for physician training are
      reappearing in the medical education literature. If history is a guide, medical
      education could be on the cusp of another set of great advances by renewing
      interest in medical humanities, reevaluating the makeup of medical school
      teaching faculty, and seeking innovations in pedagogy to facilitate active and
      integrated learning. The time is ripe to embrace the rest of the Flexner Report.
FAU - Riggs, Garrett
AU  - Riggs G
AD  - University of Central Florida College of Medicine, Orlando, Florida 32827, USA.
      ghriggs@mail.ucf.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Acad Med
JT  - Academic medicine : journal of the Association of American Medical Colleges
JID - 8904605
SB  - IM
MH  - Curriculum/*trends
MH  - Diffusion of Innovation
MH  - Education, Medical/standards/*trends
MH  - Faculty, Medical
MH  - Humanities/education
MH  - Humans
MH  - *Models, Educational
MH  - Schools, Medical/*organization & administration
MH  - Teaching/*methods
MH  - United States
EDAT- 2010/10/29 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/10/29 06:00
PHST- 2010/10/29 06:00 [entrez]
PHST- 2010/10/29 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1097/ACM.0b013e3181f5ced4 [doi]
AID - 00001888-201011000-00013 [pii]
PST - ppublish
SO  - Acad Med. 2010 Nov;85(11):1669-71. doi: 10.1097/ACM.0b013e3181f5ced4.


PMID- 20980848
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20101028
IS  - 1938-808X (Electronic)
IS  - 1040-2446 (Linking)
VI  - 85
IP  - 11
DP  - 2010 Nov
TI  - Commentary: A delicate balance: weighing the effects of conflict-of-interest
      rules on intramural research at the National Institutes of Health.
PG  - 1660-2
LID - 10.1097/ACM.0b013e3181fa3f91 [doi]
AB  - In 2005, in response to increasing public concerns about potential conflicts of
      interest in biomedical research, the Department of Health and Human Services
      (DHHS) tightened its ethics rules to prohibit National Institutes of Health (NIH)
      employees from receiving consulting fees from "significantly affected
      organizations." In response, NIH took steps to implement these regulations and
      ensure that relationships between intramural NIH researchers and industry could
      proceed without threatening the integrity of federally funded research. Examples 
      of these steps include creating an ethics advisory committee to review outside
      activities of NIH scientists and subjecting its researchers to special scrutiny
      to eliminate any perception of personal profit or conflict of interest. In the
      authors' experiences, interactions between NIH scientists and industry have
      continued relatively unaffected by these regulations. The continuing success of
      the technology transfer program at NIH and the number and types of cooperative
      research and development agreements with industry are good measures of the extent
      of productive interactions with industry since the implementation of the 2005
      ethics rules. Although recruitment of outstanding scientists to the intramural
      program has continued, these regulations also have challenged NIH's ability to
      attract and retain some of the most qualified scientists, who fear they may miss 
      certain opportunities because of the tighter regulations. As DHHS revises the
      regulations governing oversight of financial conflicts of interest in the
      extramural community, the authors recognize that the NIH intramural experience
      may provide valuable lessons about developing and implementing the next
      generation of financial conflict-of-interest rules.
FAU - Gottesman, Michael M
AU  - Gottesman MM
AD  - National Institutes of Health, Bethesda, Maryland 20852, USA. mgottesman@nih.gov
FAU - Jaffe, Holli Beckerman
AU  - Jaffe HB
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Acad Med
JT  - Academic medicine : journal of the Association of American Medical Colleges
JID - 8904605
SB  - IM
CON - Acad Med. 2010 Nov;85(11):1685-91. PMID: 20852402
MH  - Biomedical Research/*ethics
MH  - *Conflict of Interest
MH  - *Ethics, Research
MH  - Humans
MH  - *National Institutes of Health (U.S.)
MH  - Research Support as Topic/*ethics
MH  - Technology Transfer
MH  - United States
EDAT- 2010/10/29 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/10/29 06:00
PHST- 2010/10/29 06:00 [entrez]
PHST- 2010/10/29 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1097/ACM.0b013e3181fa3f91 [doi]
AID - 00001888-201011000-00010 [pii]
PST - ppublish
SO  - Acad Med. 2010 Nov;85(11):1660-2. doi: 10.1097/ACM.0b013e3181fa3f91.


PMID- 20980451
OWN - NLM
STAT- MEDLINE
DCOM- 20110201
LR  - 20211020
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 258
IP  - 1
DP  - 2011 Jan
TI  - Snapshot inversion recovery: an optimized single-shot T1-weighted
      inversion-recovery sequence for improved fetal brain anatomic delineation.
PG  - 229-35
LID - 10.1148/radiol.10100381 [doi]
AB  - PURPOSE: To prospectively evaluate the clinical effectiveness of snapshot
      inversion recovery (SNAPIR), which is a dedicated optimized
      inversion-recovery-prepared single-shot fast spin-echo T1-weighted sequence, in
      the delineation of normal fetal brain anatomy compared with that of the currently
      used T1-weighted gradient-echo protocol, which often yields images of poor
      quality due to motion artifacts and inadequate contrast. MATERIALS AND METHODS:
      This study was approved by the hospital research ethics committee, and informed
      written consent was obtained from all patients. Forty-one fetuses were examined
      at 19-37 weeks gestation (mean, 29 weeks gestation) by using both the standard
      T1-weighted protocol and the optimized T1-weighted SNAPIR protocol with a 1.5-T
      imager. Two independent blinded observers performed qualitative analysis,
      evaluating overall diagnostic quality, detailed anatomic delineation, and
      severity of motion artifacts. Quantitative analysis comprised calculation of
      contrast ratios (CRs) for the cortical gray matter, subplate, white matter, and
      cerebrospinal fluid. The Wilcoxon signed rank test was used to compare image
      rating scores, the paired t test was used to compare CRs, and kappa statistics
      were used to test interobserver agreement. RESULTS: Both overall diagnostic
      quality (P < .001) and detailed anatomic delineation (P < .001) were enhanced
      with SNAPIR compared with the standard T1-weighted acquisition. Also, motion
      artifacts were less severe (P = .008) and less extensive (P < .001) with SNAPIR. 
      Corresponding CRs were increased with SNAPIR in seven of eight examined regions. 
      CONCLUSION: SNAPIR is a promising robust alternative to the current T1-weighted
      acquisitions; its role in the detection of disease requires further study.
FAU - Malamateniou, Christina
AU  - Malamateniou C
AD  - Robert Steiner MRI Unit, Imaging Sciences Department, Clinical Sciences Centre,
      Hammersmith Hospital Campus, Imperial College, DuCane Rd, London W12 0HS,
      England. cm1@imperial.ac.uk
FAU - McGuinness, Amy K
AU  - McGuinness AK
FAU - Allsop, Joanna M
AU  - Allsop JM
FAU - O'Regan, Declan P
AU  - O'Regan DP
FAU - Rutherford, Mary A
AU  - Rutherford MA
FAU - Hajnal, Joseph V
AU  - Hajnal JV
LA  - eng
GR  - MC_U120061309/MRC_/Medical Research Council/United Kingdom
GR  - MC_U120088465/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101027
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Artifacts
MH  - Female
MH  - Fetal Diseases/*diagnosis
MH  - Gestational Age
MH  - Humans
MH  - Image Enhancement/*methods
MH  - Image Interpretation, Computer-Assisted/methods
MH  - Magnetic Resonance Imaging/*methods
MH  - Pregnancy
MH  - Prenatal Diagnosis/*methods
MH  - Prospective Studies
MH  - Statistics, Nonparametric
EDAT- 2010/10/29 06:00
MHDA- 2011/02/02 06:00
CRDT- 2010/10/29 06:00
PHST- 2010/10/29 06:00 [entrez]
PHST- 2010/10/29 06:00 [pubmed]
PHST- 2011/02/02 06:00 [medline]
AID - radiol.10100381 [pii]
AID - 10.1148/radiol.10100381 [doi]
PST - ppublish
SO  - Radiology. 2011 Jan;258(1):229-35. doi: 10.1148/radiol.10100381. Epub 2010 Oct
      27.


PMID- 20980331
OWN - NLM
STAT- MEDLINE
DCOM- 20110315
LR  - 20211020
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 12
DP  - 2010 Dec
TI  - How reproductive and regenerative medicine meet in a Chinese fertility clinic.
      Interviews with women about the donation of embryos to stem cell research.
PG  - 754-7
LID - 10.1136/jme.2010.036764 [doi]
AB  - The social interface between reproductive medicine and embryonic stem cell
      research has been investigated in a pilot study at a large IVF clinic in central 
      China. Methods included observation, interviews with hospital personnel, and five
      in-depth qualitative interviews with women who underwent IVF and who were asked
      for their consent to the donation of embryos for use in medical (in fact human
      embryonic stem cell) research. This paper reports, and discusses from an ethical 
      perspective, the results of an analysis of these interviews. The participants
      talked of extreme social pressure to become pregnant. Once they had a baby,
      'spare' embryos lost practical significance due to the Chinese one-child policy. 
      In the context of decision making about donating embryos to research, the women
      used the clinical distinctions between 'good and bad quality' embryos and also
      between frozen and transferred embryos, as guiding moral distinctions. In the
      absence of concrete information about what sort of research their embryos should 
      be used for, the women interviewed either refused consent (for fear that the
      embryo would be given to another couple) or accepted, expressing motives of
      solidarity with other women in a similar situation. This reveals that they filled
      the knowledge gap with an image of research improving fertility treatment.
FAU - Mitzkat, Anika
AU  - Mitzkat A
AD  - Institute for History, Theory and Philosophy of Medicine, Medical Center of the
      Johannes Gutenberg-University Mainz, Am Pulverturm 13, 55131 Mainz, Germany.
      mitzkat@uni-mainz.de
FAU - Haimes, Erica
AU  - Haimes E
FAU - Rehmann-Sutter, Christoph
AU  - Rehmann-Sutter C
LA  - eng
GR  - G0701109/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101027
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Embryo Disposition/*psychology
MH  - Embryo Research/*ethics
MH  - Female
MH  - Fertilization in Vitro/ethics/psychology
MH  - Humans
MH  - Informed Consent
MH  - Morals
MH  - Pilot Projects
MH  - Pregnancy
MH  - Stem Cell Transplantation/*ethics/*psychology
MH  - Surveys and Questionnaires
MH  - Tissue Donors/*psychology
MH  - Women/*psychology
EDAT- 2010/10/29 06:00
MHDA- 2011/03/16 06:00
CRDT- 2010/10/29 06:00
PHST- 2010/10/29 06:00 [entrez]
PHST- 2010/10/29 06:00 [pubmed]
PHST- 2011/03/16 06:00 [medline]
AID - jme.2010.036764 [pii]
AID - 10.1136/jme.2010.036764 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Dec;36(12):754-7. doi: 10.1136/jme.2010.036764. Epub 2010 Oct 
      27.


PMID- 20979325
OWN - NLM
STAT- MEDLINE
DCOM- 20101104
LR  - 20190612
IS  - 1474-547X (Electronic)
IS  - 0140-6736 (Linking)
VI  - 376
IP  - 9750
DP  - 2010 Oct 23
TI  - The ethics of direct-to-consumer genetic testing.
PG  - 1377-8
FAU - Udesky, Laurie
AU  - Udesky L
LA  - eng
PT  - News
PL  - England
TA  - Lancet
JT  - Lancet (London, England)
JID - 2985213R
SB  - IM
EIN - Lancet. 2011 Mar 5;377(9768):812
MH  - Commerce/*ethics
MH  - Genetic Counseling
MH  - Genetic Predisposition to Disease
MH  - Genetic Testing/*ethics/legislation & jurisprudence/standards
MH  - Humans
MH  - United States
EDAT- 2010/10/28 06:00
MHDA- 2010/11/05 06:00
CRDT- 2010/10/28 06:00
PHST- 2010/10/28 06:00 [entrez]
PHST- 2010/10/28 06:00 [pubmed]
PHST- 2010/11/05 06:00 [medline]
AID - S0140-6736(10)61939-3 [pii]
AID - 10.1016/s0140-6736(10)61939-3 [doi]
PST - ppublish
SO  - Lancet. 2010 Oct 23;376(9750):1377-8. doi: 10.1016/s0140-6736(10)61939-3.


PMID- 20979287
OWN - NLM
STAT- MEDLINE
DCOM- 20101228
LR  - 20110727
IS  - 0047-1852 (Print)
IS  - 0047-1852 (Linking)
VI  - 68 Suppl 8
DP  - 2010 Aug
TI  - [Informed consent and ethical review].
PG  - 317-21
FAU - Morisaki, Takayuki
AU  - Morisaki T
AD  - Department of Bioscience, National Cardiovascular Center Research Institute.
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Nihon Rinsho
JT  - Nihon rinsho. Japanese journal of clinical medicine
JID - 0420546
SB  - IM
MH  - *Ethics Committees
MH  - Human Genome Project
MH  - Informed Consent/*ethics
EDAT- 2010/10/28 06:00
MHDA- 2010/12/29 06:00
CRDT- 2010/10/28 06:00
PHST- 2010/10/28 06:00 [entrez]
PHST- 2010/10/28 06:00 [pubmed]
PHST- 2010/12/29 06:00 [medline]
PST - ppublish
SO  - Nihon Rinsho. 2010 Aug;68 Suppl 8:317-21.


PMID- 20978403
OWN - NLM
STAT- MEDLINE
DCOM- 20110217
LR  - 20101027
IS  - 1538-9774 (Electronic)
IS  - 1538-2931 (Linking)
VI  - 28
IP  - 6
DP  - 2010 Nov-Dec
TI  - Paradata: a new data source from web-administered measures.
PG  - 333-42; quiz 343-4
LID - 10.1097/NCN.0b013e3181f698fd [doi]
AB  - Web administration of measures offers numerous advantages as well as some
      drawbacks; the efficiency of collecting data in this way is dramatic. An
      important by-product of Web administration of measures is the option of creating 
      paradata that offer information about how respondents access a measure
      (server-side paradata) and navigate within the online environment (client-side
      paradata) to complete the measure. Paradata can play a critical role in
      developing and piloting measures as well as refining the measurement process.
      Uses of paradata in Web-administered measures include (1) informing the choice of
      response formats, (2) examining the extent of changing response options, (3)
      examining the extent of following a prescribed sequence in completing a measure, 
      (4) tracking the response process, (5) aiding in designing a Web-administered
      measure and its layout, and (6) assisting in determining the most appropriate
      log-in procedure. Because of the potential value of this new type of useful data 
      to researchers in nursing and health, this article focuses on paradata within the
      context of Web-administered measures. More specifically, the article focuses on
      the definition, generation, and uses of paradata, as well as the ethical issues
      and other concerns in obtaining and using paradata. Uses of paradata to test the 
      usability of information systems used in nursing and health practices are also
      included.
FAU - Sowan, Azizeh K
AU  - Sowan AK
AD  - School of Nursing, Hashemite University, Zarqa, Jordan.
FAU - Jenkins, Louise S
AU  - Jenkins LS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Comput Inform Nurs
JT  - Computers, informatics, nursing : CIN
JID - 101141667
SB  - IM
MH  - Clinical Nursing Research/*methods/*standards
MH  - Data Collection/*methods/*standards
MH  - Databases, Factual/standards
MH  - Education, Nursing, Continuing
MH  - Humans
MH  - Internet/*organization & administration
MH  - Nursing Informatics/*methods/standards
MH  - Quality of Health Care
EDAT- 2010/10/28 06:00
MHDA- 2011/02/18 06:00
CRDT- 2010/10/28 06:00
PHST- 2010/10/28 06:00 [entrez]
PHST- 2010/10/28 06:00 [pubmed]
PHST- 2011/02/18 06:00 [medline]
AID - 10.1097/NCN.0b013e3181f698fd [doi]
AID - 00024665-201011000-00005 [pii]
PST - ppublish
SO  - Comput Inform Nurs. 2010 Nov-Dec;28(6):333-42; quiz 343-4. doi:
      10.1097/NCN.0b013e3181f698fd.


PMID- 20977721
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1746-1340 (Electronic)
IS  - 1746-1340 (Linking)
VI  - 18
DP  - 2010 Oct 26
TI  - Withdrawal rates as a consequence of disclosure of risk associated with
      manipulation of the cervical spine.
PG  - 27
LID - 10.1186/1746-1340-18-27 [doi]
AB  - BACKGROUND: The risk associated with cervical manipulation is controversial.
      Research in this area is widely variable but as yet the risk is not easily
      quantifiable. This presents a problem when informing the patient of risks when
      seeking consent and information may be withheld due to the fear of patient
      withdrawal from care. As yet, there is a lack of research into the frequency of
      risk disclosure and consequent withdrawal from manipulative treatment as a
      result. This study seeks to investigate the reality of this and to obtain insight
      into the attitudes of chiropractors towards informed consent and disclosure.
      METHODS: Questionnaires were posted to 200 UK chiropractors randomly selected
      from the register of the General Chiropractic Council. RESULTS: A response rate
      of 46% (n = 92) was achieved. Thirty-three per cent (n = 30) respondents were
      female and the mean number of years in practice was 10. Eighty-eight per cent
      considered explanation of the risks associated with any recommended treatment
      important when obtaining informed consent. However, only 45% indicated they
      always discuss this with patients in need of cervical manipulation. When asked
      whether they believed discussing the possibility of a serious adverse reaction to
      cervical manipulation could increase patient anxiety to the extent there was a
      strong possibility the patient would refuse treatment, 46% said they believed
      this could happen. Nonetheless, 80% said they believed they had a moral/ethical
      obligation to disclose risk associated with cervical manipulation despite these
      concerns. The estimated number of withdrawals throughout respondents' time in
      practice was estimated at 1 patient withdrawal for every 2 years in practice.
      CONCLUSION: The withdrawal rate from cervical manipulation as a direct
      consequence of the disclosure of associated serious risks appears unfounded.
      However, notwithstanding legal obligations, reluctance to disclose risk due to
      fear of increasing patient anxiety still remains, despite acknowledgement of
      moral and ethical responsibility.
FAU - Langworthy, Jennifer M
AU  - Langworthy JM
AD  - Anglo-European College of Chiropractic, 13-15 Parkwood Road, Bournemouth BH5 2DF,
      UK. imrci.jlangworthy@aecc.ac.uk.
FAU - Forrest, Lianne
AU  - Forrest L
LA  - eng
PT  - Journal Article
DEP - 20101026
PL  - England
TA  - Chiropr Osteopat
JT  - Chiropractic & osteopathy
JID - 101245797
PMC - PMC3161389
EDAT- 2010/10/28 06:00
MHDA- 2010/10/28 06:01
CRDT- 2010/10/28 06:00
PHST- 2009/12/15 00:00 [received]
PHST- 2010/10/26 00:00 [accepted]
PHST- 2010/10/28 06:00 [entrez]
PHST- 2010/10/28 06:00 [pubmed]
PHST- 2010/10/28 06:01 [medline]
AID - 1746-1340-18-27 [pii]
AID - 10.1186/1746-1340-18-27 [doi]
PST - epublish
SO  - Chiropr Osteopat. 2010 Oct 26;18:27. doi: 10.1186/1746-1340-18-27.


PMID- 20977329
OWN - NLM
STAT- MEDLINE
DCOM- 20110204
LR  - 20101027
IS  - 1744-8360 (Electronic)
IS  - 1473-7175 (Linking)
VI  - 10
IP  - 11
DP  - 2010 Nov
TI  - Assessment and detection of pain in noncommunicative severely brain-injured
      patients.
PG  - 1725-31
LID - 10.1586/ern.10.148 [doi]
AB  - Detecting pain in severely brain-injured patients recovering from coma represents
      a real challenge. Patients with disorders of consciousness are unable to
      consistently or reliably communicate their feelings and potential perception of
      pain. However, recent studies suggest that patients in a minimally conscious
      state can experience pain to some extent. Pain monitoring in these patients is
      hence of medical and ethical importance. In this article, we will focus on the
      possible use of behavioral scales for the assessment and detection of pain in
      noncommunicative patients.
FAU - Schnakers, Caroline
AU  - Schnakers C
AD  - Coma Science Group, Cyclotron Research Centre, Sart Tilman, B30, University of
      Liege, 4000 Liege, Belgium. c.schnakers@ulg.ac.be
FAU - Chatelle, Camille
AU  - Chatelle C
FAU - Majerus, Steve
AU  - Majerus S
FAU - Gosseries, Olivia
AU  - Gosseries O
FAU - De Val, Marie
AU  - De Val M
FAU - Laureys, Steven
AU  - Laureys S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Expert Rev Neurother
JT  - Expert review of neurotherapeutics
JID - 101129944
SB  - IM
MH  - Coma/*complications
MH  - Humans
MH  - Pain/complications/*diagnosis
MH  - *Pain Measurement
MH  - Pain Perception
MH  - Persistent Vegetative State/*complications
EDAT- 2010/10/28 06:00
MHDA- 2011/02/05 06:00
CRDT- 2010/10/28 06:00
PHST- 2010/10/28 06:00 [entrez]
PHST- 2010/10/28 06:00 [pubmed]
PHST- 2011/02/05 06:00 [medline]
AID - 10.1586/ern.10.148 [doi]
PST - ppublish
SO  - Expert Rev Neurother. 2010 Nov;10(11):1725-31. doi: 10.1586/ern.10.148.


PMID- 20977184
OWN - NLM
STAT- MEDLINE
DCOM- 20101123
LR  - 20211203
IS  - 0963-6625 (Print)
IS  - 0963-6625 (Linking)
VI  - 19
IP  - 4
DP  - 2010 Jul
TI  - Ethnocultural community leaders' views and perceptions on biobanks and population
      specific genomic research: a qualitative research study.
PG  - 469-85
AB  - Substantial investments were made in population based biobanks over the past
      decade. Ethnocultural community members are both sponsors and beneficiaries of
      biobanks. In addition, the success of biobank projects depends on community
      support and participation. Yet there are few empirical data on views, perceptions
      and interests of ethnocultural communities on biobanks. This silent gap in
      genomics, ethics and policy literatures has to be addressed. We conducted a
      qualitative research study with in-depth interviews of ethnocultural community
      leaders (e.g., members of the Canadian Parliament, school commissioners) on their
      perspectives concerning population specific genomics research and biobanks. An
      equal partnership model where public is not only informed, but also involved in
      decision-making processes was perceived as an essential democratic requisite.
      These empirical data on ethnocultural community leaders' views, interests and
      perceptions identify several key socio-cultural and ethical factors that can be
      decisive for effective and sustainable community involvement in biobanks.
FAU - Godard, Beatrice
AU  - Godard B
AD  - Department of Preventive and Social Medicine, University of Montreal.
      beatrice.godard@umontreal.ca
FAU - Ozdemir, Vural
AU  - Ozdemir V
FAU - Fortin, Marilyn
AU  - Fortin M
FAU - Egalite, Nathalie
AU  - Egalite N
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Public Underst Sci
JT  - Public understanding of science (Bristol, England)
JID - 9306503
MH  - *Attitude
MH  - *Biological Specimen Banks
MH  - Canada
MH  - *Community Participation
MH  - Culture
MH  - Ethnicity/*psychology
MH  - *Genetic Research
MH  - *Genetics, Population
MH  - Humans
MH  - Qualitative Research
EDAT- 2010/10/28 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/10/28 06:00
PHST- 2010/10/28 06:00 [entrez]
PHST- 2010/10/28 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1177/0963662509104721 [doi]
PST - ppublish
SO  - Public Underst Sci. 2010 Jul;19(4):469-85. doi: 10.1177/0963662509104721.


PMID- 20977170
OWN - NLM
STAT- MEDLINE
DCOM- 20101210
LR  - 20101027
IS  - 1320-159X (Print)
IS  - 1320-159X (Linking)
VI  - 18
IP  - 1
DP  - 2010 Sep
TI  - Directed embryo donation: free choice or discrimination?
PG  - 169-77
AB  - The issue of whether to allow or prohibit the directed anonymous donation of
      human embryos for reproductive use has been publicly contentious. The claims that
      directed donation are a donor's autonomous right contrast with claims that the
      practice is discriminatory. Recent legislation and legal recommendation on the
      issue has been inconsistent or contradictory. This article specifically addresses
      the question as to whether the directed donation of embryos is the exercise of
      free choice or an act of discrimination. This question is considered from both
      ethical and legal viewpoints.
FAU - de Lacey, Sheryl
AU  - de Lacey S
AD  - School of Nursing and Midwifery, Flinders University, South Australia.
      sheryl.delacey@flinders.edu.au
FAU - Rogers, Wendy
AU  - Rogers W
FAU - Richards, Bernadette
AU  - Richards B
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Law Med
JT  - Journal of law and medicine
JID - 9431853
SB  - IM
MH  - Australia
MH  - Directed Tissue Donation/ethics/*legislation & jurisprudence
MH  - Embryo Disposition/ethics/legislation & jurisprudence
MH  - Humans
MH  - Prejudice
EDAT- 2010/10/28 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/10/28 06:00
PHST- 2010/10/28 06:00 [entrez]
PHST- 2010/10/28 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - J Law Med. 2010 Sep;18(1):169-77.


PMID- 20977169
OWN - NLM
STAT- MEDLINE
DCOM- 20101210
LR  - 20161125
IS  - 1320-159X (Print)
IS  - 1320-159X (Linking)
VI  - 18
IP  - 1
DP  - 2010 Sep
TI  - Rational rejection? The ethical complications of assessing organ transplant
      candidates in the United Kingdom and the United States.
PG  - 156-68
AB  - The practice of allocating scarce organs in medicine is an ethical minefield. Due
      to the organ shortage, organ procurement agencies in both the United Kingdom and 
      the United States are placed in the unenviable position of having to choose a
      limited number of patients to compete equally for life-saving treatment. They do 
      this by composing multidisciplinary transplant teams, which must evaluate
      transplant candidates and their complex range of personal, medical,
      environmental, psychiatric and financial characteristics. During the candidate
      assessment process, such teams may often be torn between their moral duty to save
      those who are most in need, considerations of efficiency, and the battle against 
      forming moral judgments about particular candidates. Several ethical approaches
      can be adopted by transplant teams during the decision-making process, but do
      these ideologies provide adequate justification for their sometimes controversial
      decisions? This article provides a detailed examination of the ethical principles
      available to transplant teams in the United Kingdom and the United States, and
      the effect that these principles have on assessment procedures, organ allocation 
      protocols, transplant candidates and their prospects.
FAU - Cherkassky, Lisa
AU  - Cherkassky L
AD  - University of Bradford, West Yorkshire, United Kingdom.
      L.Cherkassky@Bradford.ac.uk
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Law Med
JT  - Journal of law and medicine
JID - 9431853
SB  - IM
MH  - Donor Selection/*ethics
MH  - Humans
MH  - *Organ Transplantation
MH  - Tissue and Organ Procurement
MH  - United Kingdom
MH  - United States
EDAT- 2010/10/28 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/10/28 06:00
PHST- 2010/10/28 06:00 [entrez]
PHST- 2010/10/28 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - J Law Med. 2010 Sep;18(1):156-68.


PMID- 20977165
OWN - NLM
STAT- MEDLINE
DCOM- 20101210
LR  - 20101027
IS  - 1320-159X (Print)
IS  - 1320-159X (Linking)
VI  - 18
IP  - 1
DP  - 2010 Sep
TI  - Codes of professional conduct for Australian Defence Force military physicians:
      evenomating the serpent?
PG  - 103-23
AB  - The scandal of health professionals' involvement in recent human rights abuses in
      United States military detention centres has prompted concern that Australian
      military physicians should be well protected against similar pressures to
      participate in harsh interrogations. A framework of military health ethics has
      been proposed. Would a code of professional conduct be a partial solution? This
      article examines the utility of professional codes: can they transform unethical 
      behaviour or are they only of value to those who already behave ethically? How
      should such codes be designed, what support mechanisms should be in place and how
      should complaints be managed? A key recommendation is that codes of professional 
      conduct should be accompanied by publicly transparent procedures for the
      investigation of serious infractions and appropriate disciplinary action when
      proven. The training of military physicians should also aim to develop a sound
      understanding of both humanitarian and human rights law. At present, both civil
      and military education of physicians generally lacks any component of human
      rights law. The Australian Defence Force (ADF) seems well placed to add codes of 
      professional conduct to its existing ethical framework because of strong support 
      at the highest executive levels.
FAU - O'Connor, Mike
AU  - O'Connor M
AD  - St George Private Hospital, Sydney. celticdr@bigpond.net.au
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Law Med
JT  - Journal of law and medicine
JID - 9431853
SB  - IM
MH  - Australia
MH  - *Codes of Ethics
MH  - Humans
MH  - *Military Personnel
MH  - Physicians/*standards
EDAT- 2010/10/28 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/10/28 06:00
PHST- 2010/10/28 06:00 [entrez]
PHST- 2010/10/28 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - J Law Med. 2010 Sep;18(1):103-23.


PMID- 20976935
OWN - NLM
STAT- MEDLINE
DCOM- 20101228
LR  - 20121115
IS  - 0047-1852 (Print)
IS  - 0047-1852 (Linking)
VI  - 68 Suppl 8
DP  - 2010 Aug
TI  - [Ethical issues in gene therapy].
PG  - 595-600
FAU - Kato, Takiko
AU  - Kato T
AD  - School of Health Sciences, Gifu University of Medical Science.
FAU - Tami, Mariko
AU  - Tami M
LA  - jpn
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Nihon Rinsho
JT  - Nihon rinsho. Japanese journal of clinical medicine
JID - 0420546
SB  - IM
MH  - *Ethics, Medical
MH  - *Genetic Therapy/adverse effects
MH  - Humans
MH  - Risk Factors
EDAT- 2010/10/28 06:00
MHDA- 2010/12/29 06:00
CRDT- 2010/10/28 06:00
PHST- 2010/10/28 06:00 [entrez]
PHST- 2010/10/28 06:00 [pubmed]
PHST- 2010/12/29 06:00 [medline]
PST - ppublish
SO  - Nihon Rinsho. 2010 Aug;68 Suppl 8:595-600.


PMID- 20976905
OWN - NLM
STAT- MEDLINE
DCOM- 20101228
LR  - 20110727
IS  - 0047-1852 (Print)
IS  - 0047-1852 (Linking)
VI  - 68 Suppl 8
DP  - 2010 Aug
TI  - [Ethical, legal and social implication of genetic testing].
PG  - 294-8
FAU - Matsuda, Ichiro
AU  - Matsuda I
AD  - Kumamoto University.
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Nihon Rinsho
JT  - Nihon rinsho. Japanese journal of clinical medicine
JID - 0420546
SB  - IM
MH  - Child
MH  - *Ethics, Medical
MH  - Genetic Counseling
MH  - *Genetic Testing/legislation & jurisprudence
MH  - Humans
MH  - Japan
MH  - *Social Problems
EDAT- 2010/10/28 06:00
MHDA- 2010/12/29 06:00
CRDT- 2010/10/28 06:00
PHST- 2010/10/28 06:00 [entrez]
PHST- 2010/10/28 06:00 [pubmed]
PHST- 2010/12/29 06:00 [medline]
PST - ppublish
SO  - Nihon Rinsho. 2010 Aug;68 Suppl 8:294-8.


PMID- 27744804
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1472-0795 (Print)
IS  - 1472-0795 (Linking)
VI  - 22
IP  - 9
DP  - 2010 Oct 28
TI  - Interesting times.
PG  - 39
AB  - Care of older people appealed to me because it is a broad specialty with an
      emphasis on interdisciplinary working and holistic care. As well as understanding
      medical illness as 'disease', you need to focus on wellbeing and person-centred
      care beyond a disease focus. You are often looking after people with several
      problems so you need to be a good all-rounder and understand rehabilitation,
      discharge planning, the interface with community services, the roles of carers
      and relatives, and ethical and legal dilemmas.
FAU - Williams, Ruth
AU  - Williams R
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Older People
JT  - Nursing older people
JID - 101084156
EDAT- 2010/10/28 00:00
MHDA- 2010/10/28 00:01
CRDT- 2016/10/18 06:00
PHST- 2016/10/18 06:00 [entrez]
PHST- 2010/10/28 00:00 [pubmed]
PHST- 2010/10/28 00:01 [medline]
AID - 10.7748/nop.22.9.39.s24 [doi]
PST - ppublish
SO  - Nurs Older People. 2010 Oct 28;22(9):39. doi: 10.7748/nop.22.9.39.s24.


PMID- 20976480
OWN - NLM
STAT- MEDLINE
DCOM- 20110811
LR  - 20211020
IS  - 1432-2218 (Electronic)
IS  - 0930-2794 (Linking)
VI  - 25
IP  - 5
DP  - 2011 May
TI  - Do dietary spices impair the patient-reported outcomes for stapled
      hemorrhoidopexy? A randomized controlled study.
PG  - 1535-40
LID - 10.1007/s00464-010-1431-1 [doi]
AB  - BACKGROUND: Postoperative pain is a concern for patients seeking hemorrhoid
      surgery. Stapled hemorrhoidopexy is popular due to better patient-reported
      outcomes (PROs). Pain is the index of PROs. Posthemorrhoidectomy patients usually
      opt for a spice-free diet due to fear of pain or anal pruritus induced by spices.
      Curcumin and peprin (spice constituents) have powerful antiinflammatory and
      antioxidant properties. Ability to resume a normal taste-habituated meal may
      improve PRO quality of life. Thus, spice-related paradoxic conservatism in
      stapled hemorrhoidopexy, which involves no open wound, needed to be studied.
      METHODS: A prospective open-ended study (July 2008 to August 2009) investigated
      consecutive candidates for day-care stapled hemorrhoidopexy randomized by the
      date of birth method into a controlled group (receiving a spices-free diet) and a
      study group (receiving a spicy diet) after an ethics and informed consent
      protocol. A standard perioperative protocol was followed. At discharge, the
      patients were advised to resume a normal diet (spicy or bland) and instructed to 
      maintain a pain diary (100-point visual analog scale [VAS]) and an analgesic
      diary. Paracetamol 650 mg was used for pain exceeding a VAS score of 25. Patients
      were followed on day 3 and weeks 1 and 3. Failure to be discharged from day care,
      failure to maintain patient diary, and squamous epithelium in the rectal donut
      were the withdrawal criteria. RESULTS: A total of 67 patients were randomized.
      The groups were well matched for demographics, comorbidities, types of
      anesthesia, hemorrhoidal grades, and withdrawal. Statistically significant
      improvement in PROs (P<0.05) and a lower consumption of analgesic tablets were
      seen in the study group (spicy diet). No adverse event was reported in either
      group. CONCLUSION: Resumption of a spicy diet has no adverse impact on PROs after
      stapled hemorrhoidopexy. Reduced analgesic usage in the spicy diet study group
      needs to be evaluated further for any potential benefits of spices.
FAU - Agarwal, Brij B
AU  - Agarwal BB
AD  - Dr. Agarwal's Surgery & Yoga, F81 & 82, Street no. 4, Virender Nagar, New Delhi, 
      110058, India. endosurgeon@gmail.com
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20101026
PL  - Germany
TA  - Surg Endosc
JT  - Surgical endoscopy
JID - 8806653
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Diet
MH  - Female
MH  - Hemorrhoids/*surgery
MH  - Humans
MH  - India
MH  - Male
MH  - Middle Aged
MH  - Pain Measurement
MH  - *Pain, Postoperative/prevention & control
MH  - *Spices/adverse effects
MH  - *Surgical Stapling
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2010/10/27 06:00
MHDA- 2011/08/13 06:00
CRDT- 2010/10/27 06:00
PHST- 2010/05/22 00:00 [received]
PHST- 2010/09/27 00:00 [accepted]
PHST- 2010/10/27 06:00 [entrez]
PHST- 2010/10/27 06:00 [pubmed]
PHST- 2011/08/13 06:00 [medline]
AID - 10.1007/s00464-010-1431-1 [doi]
PST - ppublish
SO  - Surg Endosc. 2011 May;25(5):1535-40. doi: 10.1007/s00464-010-1431-1. Epub 2010
      Oct 26.


PMID- 20975855
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120917
LR  - 20220331
IS  - 2051-5545 (Electronic)
IS  - 1723-8617 (Linking)
VI  - 9
IP  - 3
DP  - 2010 Oct
TI  - WPA guidance on how to combat stigmatization of psychiatry and psychiatrists.
PG  - 131-44
AB  - In 2009 the WPA President established a Task Force that was to examine available 
      evidence about the stigmatization of psychiatry and psychiatrists and to make
      recommendations about action that national psychiatric societies and
      psychiatrists as professionals could do to reduce or prevent the stigmatization
      of their discipline as well as to prevent its nefarious consequences. This paper 
      presents a summary of the Task Force's findings and recommendations. The Task
      Force reviewed the literature concerning the image of psychiatry and
      psychiatrists in the media and the opinions about psychiatry and psychiatrists of
      the general public, of students of medicine, of health professionals other than
      psychiatrists and of persons with mental illness and their families. It also
      reviewed the evidence about the interventions that have been undertaken to combat
      stigma and consequent discrimination and made a series of recommendations to the 
      national psychiatric societies and to individual psychiatrists. The Task Force
      laid emphasis on the formulation of best practices of psychiatry and their
      application in health services and on the revision of curricula for the training 
      of health personnel. It also recommended that national psychiatric societies
      establish links with other professional associations, with organizations of
      patients and their relatives and with the media in order to approach the problems
      of stigma on a broad front. The Task Force also underlined the role that
      psychiatrists can play in the prevention of stigmatization of psychiatry,
      stressing the need to develop a respectful relationship with patients, to
      strictly observe ethical rules in the practice of psychiatry and to maintain
      professional competence.
FAU - Sartorius, Norman
AU  - Sartorius N
AD  - Association for the Improvement of Mental Health Programmes, Geneva, Switzerland.
FAU - Gaebel, Wolfgang
AU  - Gaebel W
FAU - Cleveland, Helen-Rose
AU  - Cleveland HR
FAU - Stuart, Heather
AU  - Stuart H
FAU - Akiyama, Tsuyoshi
AU  - Akiyama T
FAU - Arboleda-Florez, Julio
AU  - Arboleda-Florez J
FAU - Baumann, Anja E
AU  - Baumann AE
FAU - Gureje, Oye
AU  - Gureje O
FAU - Jorge, Miguel R
AU  - Jorge MR
FAU - Kastrup, Marianne
AU  - Kastrup M
FAU - Suzuki, Yuriko
AU  - Suzuki Y
FAU - Tasman, Allan
AU  - Tasman A
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - World Psychiatry
JT  - World psychiatry : official journal of the World Psychiatric Association (WPA)
JID - 101189643
PMC - PMC2948719
OTO - NOTNLM
OT  - Stigmatization
OT  - ethical rules
OT  - general public
OT  - media
OT  - medical students
OT  - patients and relatives
OT  - psychiatrists
OT  - psychiatry
EDAT- 2010/10/27 06:00
MHDA- 2010/10/27 06:01
CRDT- 2010/10/27 06:00
PHST- 2010/10/27 06:00 [entrez]
PHST- 2010/10/27 06:00 [pubmed]
PHST- 2010/10/27 06:01 [medline]
AID - 10.1002/j.2051-5545.2010.tb00296.x [doi]
PST - ppublish
SO  - World Psychiatry. 2010 Oct;9(3):131-44. doi: 10.1002/j.2051-5545.2010.tb00296.x.


PMID- 20975853
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 1705-7841 (Print)
IS  - 1705-7841 (Linking)
VI  - 8
IP  - 2
DP  - 2010 Fall
TI  - Rebuilding from Resilience: Research Framework for a Randomized Controlled Trial 
      of Community-led Interventions to Prevent Domestic Violence in Aboriginal
      Communities.
PG  - 61-88
AB  - This research framework, which competed successfully in the 2008 CIHR open
      operating grants competition, focuses on protocols to measure the impact of
      community-led interventions to reduce domestic violence in Aboriginal
      communities. The project develops and tests tools and procedures for a randomized
      controlled trial of prevention of family violence. Women's shelters mainly deal
      with victims of domestic violence, and the framework also addresses other types
      of domestic violence (male and female children, elderly, and disabled). The
      partner shelters are in Aboriginal communities across Canada, on and off reserve,
      in most provinces and territories. The baseline study applies a questionnaire
      developed by the shelters. Testing the stepped wedge design in an Aboriginal
      context, shelters randomized themselves to two waves of intervention, half the
      shelters receiving the resources for the first wave. A repeat survey after two
      years will measure the difference between first wave and second wave, after which
      the resources will shift to the second wave. At least two Aboriginal researchers 
      will complete their doctoral studies in the project. The steering committee of 12
      shelter directors guides the project and ensures ethical standards related to
      their populations. Each participating community and the University of Ottawa
      reviewed and passed the proposal.
FAU - Andersson, Neil
AU  - Andersson N
FAU - Shea, Beverley
AU  - Shea B
FAU - Amaratunga, Carol
AU  - Amaratunga C
FAU - McGuire, Patricia
AU  - McGuire P
FAU - Sioui, Georges
AU  - Sioui G
LA  - eng
GR  - 84489/CAPMC/ CIHR/Canada
GR  - 84489/PHS HHS/United States
PT  - Journal Article
PL  - Canada
TA  - Pimatisiwin
JT  - Pimatisiwin
JID - 101465108
PMC - PMC2962657
MID - CAMS1504
EDAT- 2010/10/27 06:00
MHDA- 2010/10/27 06:01
CRDT- 2010/10/27 06:00
PHST- 2010/10/27 06:00 [entrez]
PHST- 2010/10/27 06:00 [pubmed]
PHST- 2010/10/27 06:01 [medline]
PST - ppublish
SO  - Pimatisiwin. 2010 Fall;8(2):61-88.


PMID- 20975851
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 1705-7841 (Print)
IS  - 1705-7841 (Linking)
VI  - 8
IP  - 2
DP  - 2010 Fall
TI  - Family Violence and the Need for Prevention Research in First Nations, Inuit, and
      Metis Communities.
PG  - 9-33
AB  - Existing sources produce widely varying estimates of family violence in First
      Nations, Inuit, and Metis communities; taken together, they imply a convincing if
      poorly quantified higher risk of family violence in Aboriginal communities, with 
      the greater burden borne by women. With the accelerating HIV epidemic in some
      Aboriginal communities, prevention of domestic violence takes on even greater
      urgency. Five planks in a prevention research platform include: training emerging
      researchers from all Aboriginal groups to promote culturally specific research;
      systematic review of unpublished and published knowledge of interventions that
      reduce domestic violence; intervention theory development specific to each
      community; attention to the particular ethical issues; and methods development
      focused on interventions.
FAU - Andersson, Neil
AU  - Andersson N
FAU - Nahwegahbow, Amy
AU  - Nahwegahbow A
LA  - eng
GR  - 84489/CAPMC/ CIHR/Canada
GR  - 84489/PHS HHS/United States
PT  - Journal Article
PL  - Canada
TA  - Pimatisiwin
JT  - Pimatisiwin
JID - 101465108
PMC - PMC2962655
MID - CAMS1502
EDAT- 2010/10/27 06:00
MHDA- 2010/10/27 06:01
CRDT- 2010/10/27 06:00
PHST- 2010/10/27 06:00 [entrez]
PHST- 2010/10/27 06:00 [pubmed]
PHST- 2010/10/27 06:01 [medline]
PST - ppublish
SO  - Pimatisiwin. 2010 Fall;8(2):9-33.


PMID- 20974506
OWN - NLM
STAT- MEDLINE
DCOM- 20111006
LR  - 20110603
IS  - 1532-2793 (Electronic)
IS  - 0260-6917 (Linking)
VI  - 31
IP  - 5
DP  - 2011 Jul
TI  - Tolstoy, stories, and facilitating insight in end of life care: exploring ethics 
      through vicarious experience.
PG  - 516-20
LID - 10.1016/j.nedt.2010.09.004 [doi]
AB  - Facilitating moral insight in end of life care can be challenging, and the
      purpose of this paper is to illustrate how this can be nurtured by means of
      creative literature. Tolstoy's Death of Ivan Ilych is presented as an example of 
      such literature. Aristotle's Nichomean Ethics provides the philosophical
      underpinning for the method used. Sources also include the nursing literature,
      and students' evaluations of the impact of Tolstoy's novella on their ability to 
      perceive the ethical issues arising in end of life care. Comments from
      evaluations were analysed and significant themes emerged. Students' comments
      clearly support the suggestion that use of this novella has facilitated insight
      into ethical issues at the end of life. Evaluations also indicate that vicarious 
      experience gained through reading this novella has helped to nurture sensitivity 
      and professional insight into the importance of compassion and offering 'comfort'
      to the dying person.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Begley, Ann Marie
AU  - Begley AM
AD  - School of Nursing and Midwifery, Queen's University Belfast, Northern Ireland, BT
      9 7HH, United Kingdom. a.begley@qub.ac.uk
FAU - Glackin, Marie
AU  - Glackin M
FAU - Henry, Richard
AU  - Henry R
LA  - eng
PT  - Journal Article
DEP - 20101025
PL  - Scotland
TA  - Nurse Educ Today
JT  - Nurse education today
JID - 8511379
MH  - Education, Nursing/*methods
MH  - Empathy
MH  - Humans
MH  - *Medicine in Literature
MH  - Morals
MH  - Nurse-Patient Relations
MH  - Terminal Care/*ethics
EDAT- 2010/10/27 06:00
MHDA- 2011/10/07 06:00
CRDT- 2010/10/27 06:00
PHST- 2010/02/16 00:00 [received]
PHST- 2010/08/12 00:00 [revised]
PHST- 2010/09/13 00:00 [accepted]
PHST- 2010/10/27 06:00 [entrez]
PHST- 2010/10/27 06:00 [pubmed]
PHST- 2011/10/07 06:00 [medline]
AID - S0260-6917(10)00167-X [pii]
AID - 10.1016/j.nedt.2010.09.004 [doi]
PST - ppublish
SO  - Nurse Educ Today. 2011 Jul;31(5):516-20. doi: 10.1016/j.nedt.2010.09.004. Epub
      2010 Oct 25.


PMID- 20974022
OWN - NLM
STAT- MEDLINE
DCOM- 20110216
LR  - 20101026
IS  - 1471-6348 (Electronic)
IS  - 0266-4623 (Linking)
VI  - 26
IP  - 4
DP  - 2010 Oct
TI  - Functionalities of free and open electronic health record systems.
PG  - 382-9
LID - 10.1017/S0266462310001121 [doi]
AB  - OBJECTIVES: The aim of this study was to examine open-source electronic health
      record (EHR) software to determine their level of functionalities according to
      the International Organization for Standardization (ISO) standards. METHODS: ISO 
      standards were used as a guideline to determine and describe the reference
      architecture and functionalities of a standard electronic health record system as
      well the environmental context for which the software has been built. Twelve
      open-source EHR systems were selected and evaluated according to two-dimensional 
      criteria based on ISO/TS 18308:2004 functional requirements and ISO/TR 20514:2005
      context of the EHR system. RESULTS: Open EHR software programs mostly fulfill
      structural, procedural, evolutional, and medicolegal requirements at the minimal 
      and full functionality levels. Communication, privacy, and security requirements 
      are accomplished in less than 23 percent of the cases, mainly at minimal
      functional level. Ethical, cultural, and consumer requirements still need to be
      fulfilled by free and open-source EHR applications. CONCLUSIONS: Most analyzed
      systems had several functional limitations. Nevertheless, especially for
      clinicians and decision makers in developing countries, open-source EHR systems
      are an option. The limited functionalities are likely to become requirements for 
      further releases of open-source EHR systems.
FAU - Flores Zuniga, Alejandro Enrique
AU  - Flores Zuniga AE
AD  - School of Information Systems and Technology, University ofWollongong,
      Northfields Avenue, Wollongong, NSW 2522, Australia. aefz871@uow.edu.au
FAU - Win, Khin Than
AU  - Win KT
FAU - Susilo, Willy
AU  - Susilo W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Technol Assess Health Care
JT  - International journal of technology assessment in health care
JID - 8508113
SB  - IM
MH  - *Access to Information
MH  - Electronic Health Records/legislation & jurisprudence/*standards
MH  - *Guideline Adherence
MH  - Humans
MH  - Internationality
MH  - Software
EDAT- 2010/10/27 06:00
MHDA- 2011/02/17 06:00
CRDT- 2010/10/27 06:00
PHST- 2010/10/27 06:00 [entrez]
PHST- 2010/10/27 06:00 [pubmed]
PHST- 2011/02/17 06:00 [medline]
AID - S0266462310001121 [pii]
AID - 10.1017/S0266462310001121 [doi]
PST - ppublish
SO  - Int J Technol Assess Health Care. 2010 Oct;26(4):382-9. doi:
      10.1017/S0266462310001121.


PMID- 20973280
OWN - NLM
STAT- MEDLINE
DCOM- 20110204
LR  - 20191111
IS  - 1745-8315 (Electronic)
IS  - 0020-7578 (Linking)
VI  - 91
IP  - 4
DP  - 2010 Aug
TI  - Collateral damage: grief and recovery after losing a training analyst due to an
      ethical violation.
PG  - 963-5
FAU - Gabbard, Glen
AU  - Gabbard G
AD  - elizabethm.wallace@albertahealthservices.ca
FAU - Wallace, Elizabeth
AU  - Wallace E
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Psychoanal
JT  - The International journal of psycho-analysis
JID - 2985179R
SB  - IM
MH  - *Ethics, Medical
MH  - *Grief
MH  - Humans
MH  - *Physician-Patient Relations
MH  - *Psychoanalytic Therapy/education
EDAT- 2010/10/27 06:00
MHDA- 2011/02/05 06:00
CRDT- 2010/10/27 06:00
PHST- 2010/10/27 06:00 [entrez]
PHST- 2010/10/27 06:00 [pubmed]
PHST- 2011/02/05 06:00 [medline]
AID - 10.1111/j.1745-8315.2010.00301.x [doi]
PST - ppublish
SO  - Int J Psychoanal. 2010 Aug;91(4):963-5. doi: 10.1111/j.1745-8315.2010.00301.x.


PMID- 20963300
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20191210
IS  - 0124-0064 (Print)
IS  - 0124-0064 (Linking)
VI  - 12 Suppl 1
DP  - 2010
TI  - [Ethical principles and approaches to health systems governance research:
      conceptual and methodological implications].
PG  - 28-38
LID - S0124-00642010000700003 [pii]
AB  - Governance refers to decision-making processes in which power relationships and
      actors and institutions' particular interests converge. Situations of consensus
      and conflict are inherent to such processes. Furthermore, decision-making happens
      within a framework of ethical principles, motivations and incentives which could 
      be explicit or implicit. Health systems in most Latin-American and Caribbean
      countries take the principles of equity, solidarity, social participation and the
      right to health as their guiding principles; such principles must thus rule
      governance processes. However, this is not always the case and this is where the 
      importance of investigating governance in health systems lies. Making advances in
      investigating governance involves conceptual and methodological implications.
      Clarifying and integrating normative and analytical approaches is relevant at
      conceptual level as both are necessary for an approach seeking to investigate and
      understand social phenomena's complexity. In relation to methodological level,
      there is a need to expand the range of variables, sources of information and
      indicators for studying decision-making aimed to greater equity, health
      citizenship and public policy efficiency.
FAU - Flores, Walter
AU  - Flores W
AD  - Centro de Estudios para la Equidad y Gobernanza en los Sistemas de Salud,
      Guatemala. wflores@cegss.org.gt
LA  - spa
PT  - Journal Article
TT  - Los principios eticos y los enfoques asociados a la investigacion de la
      gobernanza en los sistemas de salud: implicaciones conceptuales y metodologicas.
PL  - Colombia
TA  - Rev Salud Publica (Bogota)
JT  - Revista de salud publica (Bogota, Colombia)
JID - 100936348
SB  - IM
MH  - *Decision Making, Organizational
MH  - Health Services Administration/*ethics
MH  - Health Services Research/*ethics
MH  - Latin America
MH  - Policy Making
MH  - *Power, Psychological
MH  - Program Evaluation
MH  - Social Change
MH  - Social Justice
MH  - Social Values
EDAT- 2010/10/27 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/10/22 06:00
PHST- 2009/07/15 00:00 [received]
PHST- 2010/01/15 00:00 [accepted]
PHST- 2010/10/22 06:00 [entrez]
PHST- 2010/10/27 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - S0124-00642010000700003 [pii]
AID - 10.1590/s0124-00642010000700003 [doi]
PST - ppublish
SO  - Rev Salud Publica (Bogota). 2010;12 Suppl 1:28-38. doi:
      10.1590/s0124-00642010000700003.


PMID- 20971785
OWN - NLM
STAT- MEDLINE
DCOM- 20101101
LR  - 20181023
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 341
DP  - 2010 Oct 22
TI  - Ethics experts agree that {pound}250 cap for egg donation should be lifted.
PG  - c5976
LID - 10.1136/bmj.c5976 [doi]
LID - bmj.c5976 [pii]
FAU - Dyer, Clare
AU  - Dyer C
LA  - eng
PT  - News
DEP - 20101022
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
SB  - IM
MH  - Female
MH  - Humans
MH  - *Income
MH  - Oocyte Donation/economics/*ethics
EDAT- 2010/10/26 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/10/26 06:00
PHST- 2010/10/26 06:00 [entrez]
PHST- 2010/10/26 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - 10.1136/bmj.c5976 [doi]
PST - epublish
SO  - BMJ. 2010 Oct 22;341:c5976. doi: 10.1136/bmj.c5976.


PMID- 20971776
OWN - NLM
STAT- MEDLINE
DCOM- 20110317
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 258
IP  - 2
DP  - 2011 Feb
TI  - Correlation of carotid artery atherosclerotic lesion echogenicity and severity at
      standard US with intraplaque neovascularization detected at contrast-enhanced US.
PG  - 618-26
LID - 10.1148/radiol.10101008 [doi]
AB  - PURPOSE: To correlate echogenicity and severity of atherosclerotic carotid artery
      lesions at standard ultrasonography (US) with the degree of intraplaque
      neovascularization at contrast material-enhanced (CE) US. MATERIALS AND METHODS: 
      This HIPAA-compliant study was approved by the local ethics committee, and all
      patients provided informed consent. A total of 175 patients (113 [65%] men, 62
      [35%] women; mean age, 67 years +/- 10 [standard deviation]) underwent standard
      and CE US of the carotid artery. Lesion echogenicity (class I to IV), degree of
      stenosis, and maximal lesion thickness were evaluated for each documented
      atherosclerotic lesion. The degree of intraplaque neovascularization at CE US was
      categorized as absent (grade 1), moderate (grade 2), or extensive (grade 3).
      Correlation of neovascularization with echogenicity, degree of stenosis, and
      maximal lesion thickness was made by using Spearman rho and chi(2) test for
      trend. RESULTS: In a total of 293 atherosclerotic lesions, echogenicity was
      inversely correlated with grade of intraplaque neovascularization (rho = -0.199, 
      P < .001). More echolucent lesions had a higher degree of neovascularization
      compared with more echogenic ones (P < .001). The degree of stenosis was
      significantly correlated with grade of intraplaque neovascularization (rho =
      0.157, P = .003). Lesions with higher degree of stenosis had higher grade of
      neovascularization (P = .008), and maximal lesion thickness increased with the
      grade of neovascularization (P < .001) and was significantly correlated with
      grade of neovascularization (rho = 0.233, P < .001). CONCLUSION:
      Neovascularization visualized with CE US correlates with lesion severity and with
      morphologic features of plaque instability, contributing to the concept that more
      vulnerable plaques are more likely to have a greater degree of
      neovascularization. Therefore, CE US may be a valuable tool for further risk
      stratification of echolucent atherosclerotic lesions and carotid artery stenosis 
      of different degrees. SUPPLEMENTAL MATERIAL:
      http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.10101008/-/DC1.
CI  - (c) RSNA, 2011
FAU - Staub, Daniel
AU  - Staub D
AD  - Department of Internal Medicine, Section of Cardiology, Rush University Medical
      Center, Chicago, Ill, USA. StaubD@uhbs.ch
FAU - Partovi, Sasan
AU  - Partovi S
FAU - Schinkel, Arend F L
AU  - Schinkel AF
FAU - Coll, Blai
AU  - Coll B
FAU - Uthoff, Heiko
AU  - Uthoff H
FAU - Aschwanden, Markus
AU  - Aschwanden M
FAU - Jaeger, Kurt A
AU  - Jaeger KA
FAU - Feinstein, Steven B
AU  - Feinstein SB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101022
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Albumins)
RN  - 0 (Contrast Media)
RN  - 0 (FS 069)
RN  - 0 (Fluorocarbons)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Albumins
MH  - Analysis of Variance
MH  - Atherosclerosis/*diagnostic imaging/pathology
MH  - Carotid Stenosis/*diagnostic imaging/pathology
MH  - Chi-Square Distribution
MH  - Contrast Media
MH  - Female
MH  - Fluorocarbons
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Ultrasonography
EDAT- 2010/10/26 06:00
MHDA- 2011/03/18 06:00
CRDT- 2010/10/26 06:00
PHST- 2010/10/26 06:00 [entrez]
PHST- 2010/10/26 06:00 [pubmed]
PHST- 2011/03/18 06:00 [medline]
AID - radiol.10101008 [pii]
AID - 10.1148/radiol.10101008 [doi]
PST - ppublish
SO  - Radiology. 2011 Feb;258(2):618-26. doi: 10.1148/radiol.10101008. Epub 2010 Oct
      22.


PMID- 20971402
OWN - NLM
STAT- MEDLINE
DCOM- 20110307
LR  - 20131121
IS  - 1878-3449 (Electronic)
IS  - 0749-2081 (Linking)
VI  - 26
IP  - 4
DP  - 2010 Nov
TI  - Pediatric palliative care in childhood cancer nursing: from diagnosis to cure or 
      end of life.
PG  - 205-21
LID - 10.1016/j.soncn.2010.08.003 [doi]
AB  - OBJECTIVES: To describe selected components of pediatric palliative care from
      diagnosis to cure or end of life that combine to help nurses and other clinicians
      achieve goals of care for children with cancer and their families. DATA SOURCES: 
      Published articles. CONCLUSION: Pediatric palliative care is characterized by
      diversity of care delivery models; effect of cancer on the family as the central 
      focus of care; and consideration of culture, spirituality, communication, and
      ethical standards. End-of-life issues that can be anticipated by nurses and other
      clinicians include symptoms of cancer or its treatment, the importance of
      hopefulness, the relevance of trying to be a good parent in decision making, the 
      meaning of legacy making of ill children, and family bereavement. IMPLICATIONS
      FOR NURSING PRACTICE: Direct nursing care strategies to achieve pediatric
      palliative care goals are vital to reduce child and family suffering from cancer.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Foster, Terrah L
AU  - Foster TL
AD  - School of Nursing, Vanderbilt University, Nashville, TN 37240, USA.
      terrah.L.foster@vanderbilt.edu
FAU - Lafond, Deborah A
AU  - Lafond DA
FAU - Reggio, Cheryl
AU  - Reggio C
FAU - Hinds, Pamela S
AU  - Hinds PS
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Semin Oncol Nurs
JT  - Seminars in oncology nursing
JID - 8504688
SB  - IM
MH  - Bereavement
MH  - Child
MH  - Communication
MH  - Culture
MH  - Ethics, Nursing
MH  - Humans
MH  - Neoplasms/*nursing
MH  - *Oncology Nursing
MH  - *Palliative Care
MH  - *Pediatric Nursing
MH  - Professional-Family Relations
MH  - Spirituality
EDAT- 2010/10/26 06:00
MHDA- 2011/03/08 06:00
CRDT- 2010/10/26 06:00
PHST- 2010/10/26 06:00 [entrez]
PHST- 2010/10/26 06:00 [pubmed]
PHST- 2011/03/08 06:00 [medline]
AID - S0749-2081(10)00050-1 [pii]
AID - 10.1016/j.soncn.2010.08.003 [doi]
PST - ppublish
SO  - Semin Oncol Nurs. 2010 Nov;26(4):205-21. doi: 10.1016/j.soncn.2010.08.003.


PMID- 20970684
OWN - NLM
STAT- MEDLINE
DCOM- 20110328
LR  - 20101025
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 42
IP  - 8
DP  - 2010 Oct
TI  - "Medical writing" and ghostwriting as ethical challenges in medical
      communication.
PG  - 3335-7
LID - 10.1016/j.transproceed.2010.07.023 [doi]
AB  - In the past years, it has become increasingly apparent that ghostwriting may
      erode the public trust in medical science and scientific publishing. It is
      estimated that approximately 10% of articles published in reputed journals are
      ghostwritten, and this rate may be even higher in some medical specialties.
      Although this practice is rather universally condemned, the propriety of
      participation of professional writers in producing papers remains an open
      question. Although some believe this practice should also be banned, others argue
      that such stringent policy would increase nonpublication and rather encourage
      disclosure; but should medical writers be included as authors on the final
      version of manuscripts? These and other questions should be solved to maintain
      the high scientific and ethical standards of medical communication and public
      trust in medicine.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Gorski, A
AU  - Gorski A
AD  - Medical University of Warsaw, Warsaw, Poland. agorski@ikp.pl
FAU - Letkiewicz, S
AU  - Letkiewicz S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - *Communication
MH  - *Ethics
MH  - *Journalism, Medical
EDAT- 2010/10/26 06:00
MHDA- 2011/03/29 06:00
CRDT- 2010/10/26 06:00
PHST- 2010/10/26 06:00 [entrez]
PHST- 2010/10/26 06:00 [pubmed]
PHST- 2011/03/29 06:00 [medline]
AID - S0041-1345(10)01068-7 [pii]
AID - 10.1016/j.transproceed.2010.07.023 [doi]
PST - ppublish
SO  - Transplant Proc. 2010 Oct;42(8):3335-7. doi: 10.1016/j.transproceed.2010.07.023.


PMID- 20970553
OWN - NLM
STAT- MEDLINE
DCOM- 20110328
LR  - 20151119
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 42
IP  - 8
DP  - 2010 Oct
TI  - Toward personalized medicine in renal transplantation.
PG  - 2864-7
LID - 10.1016/j.transproceed.2010.08.009 [doi]
AB  - BACKGROUND: The pharmacokinetics of tacrolimus (TRL) are clearly affected by
      genetic polymorphisms in drug-metabolizing enzymes, which lead to large
      interindividual differences in dose-response relations. In addition, TRL has a
      narrow therapeutic index requiring monitoring of blood levels. The objective of
      the present observational, retrospective study was to associate maintenance TRL
      doses with various genetic markers seeking to guide optimization of the initial
      dose. METHODS: Results of DNA samples from 15 kidney transplant patients were
      correlated retrospectively with clinical information from medical records.
      Samples were genotyped using PHARMAchip. Association studies were performed with 
      chi2 and Pearson tests and by analysis of variance. The study was carried out in 
      accordance with international ethical standards of the Helsinki Declaration and
      approved by our ethics committee. RESULTS: Two patient groups were identified to 
      show a difference in TRL dose requirements: a control (0.014-0.10 mg/kg/per day) 
      and an high-dose group (0.14-0.15 mg/kg/per day). The presence of CYP3A5*1 and
      the null allele in GSTM1 were significantly associated (P=.01 and P=.04) with the
      need for higher immunosuppressive doses (>0.10 mg/kg/per day). There were no
      differences in plasma levels of TRL or other clinical variables between the
      patient groups. CONCLUSION: Determination of the CYP3A5 genotype might be used to
      predict initial TRL requirements, although other genetic variants also provide
      important information to adjust the drug dose.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Lampreabe, I
AU  - Lampreabe I
AD  - Nephrology Department, Hospital Cruces, Bilbao, Spain.
      ildefonso.lampreabegaztelu@osakidetza.net
FAU - Gainza de los Rios, F J
AU  - Gainza de los Rios FJ
FAU - Arrieta Gutierrez, A
AU  - Arrieta Gutierrez A
FAU - Jofre-Monseny, L
AU  - Jofre-Monseny L
FAU - Rodriguez, M
AU  - Rodriguez M
FAU - Amenabar Iribar, J J
AU  - Amenabar Iribar JJ
FAU - Zarraga Larrondo, S
AU  - Zarraga Larrondo S
FAU - Tejedor, D
AU  - Tejedor D
FAU - Martinez, A
AU  - Martinez A
FAU - Olano-Martin, E
AU  - Olano-Martin E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - 0 (Genetic Markers)
RN  - 0 (Immunosuppressive Agents)
RN  - 9007-49-2 (DNA)
RN  - EC 1.14.14.1 (CYP3A5 protein, human)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP3A)
RN  - WM0HAQ4WNM (Tacrolimus)
SB  - IM
MH  - Cytochrome P-450 CYP3A/genetics
MH  - DNA/genetics
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Genetic Markers
MH  - Humans
MH  - Immunosuppressive Agents/administration & dosage/*pharmacokinetics/therapeutic
      use
MH  - *Kidney Transplantation
MH  - Male
MH  - *Precision Medicine
MH  - Retrospective Studies
MH  - Tacrolimus/administration & dosage/*pharmacokinetics/therapeutic use
EDAT- 2010/10/26 06:00
MHDA- 2011/03/29 06:00
CRDT- 2010/10/26 06:00
PHST- 2010/10/26 06:00 [entrez]
PHST- 2010/10/26 06:00 [pubmed]
PHST- 2011/03/29 06:00 [medline]
AID - S0041-1345(10)01209-1 [pii]
AID - 10.1016/j.transproceed.2010.08.009 [doi]
PST - ppublish
SO  - Transplant Proc. 2010 Oct;42(8):2864-7. doi: 10.1016/j.transproceed.2010.08.009.


PMID- 20969763
OWN - NLM
STAT- MEDLINE
DCOM- 20110609
LR  - 20220408
IS  - 1471-2288 (Electronic)
IS  - 1471-2288 (Linking)
VI  - 10
DP  - 2010 Oct 22
TI  - Balancing high accrual and ethical recruitment in paediatric oncology: a
      qualitative study of the 'look and feel' of clinical trial discussions.
PG  - 101
LID - 10.1186/1471-2288-10-101 [doi]
AB  - BACKGROUND: High accrual to clinical trials enables new treatment strategies to
      be tested rapidly, accurately and with generalisability. Ethical standards also
      must be high so that participation is voluntary and informed. However, this can
      be difficult to achieve in trials with complex designs and in those which are
      closely embedded in clinical practice. Optimal recruitment requires a balance of 
      both ethical and accrual considerations. In the context of a trial of stratified 
      treatments for children with acute lymphoblastic leukaemia (UKALL2003) we
      examined how recruitment looked to an observer and how it felt to the parents, to
      identify how doctors' communication could promote or inhibit optimal recruitment.
      METHODS: We audio-recorded, transcribed and analysed routine doctor-patient
      consultations (n = 20) and interviews between researchers and parents (n = 30
      parents) across six UK treatment centres. Analysis was informed by the constant
      comparative method. For consultation transcripts, analysis focussed on how
      doctors presented the trial. We compared this with analysis of the interview
      transcripts which focussed on parents' perceptions and understanding of the
      trial. RESULTS: Parents and doctors discussed the trial in most consultations,
      even those that did not involve a decision about randomisation. Doctors used
      language allying them both with the trial and with the parent, indicating that
      they were both an 'investigator' and a 'clinician'. They presented the trial both
      as an empirical study with a scientific imperative and also as offering
      personalisation of treatment for the child. Parents appeared to understand that
      trial involvement was voluntary, that it was different from routine care and that
      they could withdraw from the trial at any time. Some were confused about the
      significance of the MRD test and the personalisation of treatment. CONCLUSIONS:
      Doctors communicated in ways that generally promoted optimal recruitment,
      indicating that trials can be embedded into clinical practice. However, parents
      were unclear about some details of the trial's rationale, suggesting that
      recruitment to trials with complicated designs, such as those involving
      stratified treatments, might need enhanced explanation.
FAU - Byrne-Davis, Lucie M T
AU  - Byrne-Davis LM
AD  - University of Manchester, Education & Research Centre, University Hospital of
      South Manchester, Southmoor Road, Manchester M23 9LT, UK.
      lucie.byrne-davis@manchester.ac.uk
FAU - Salmon, Peter
AU  - Salmon P
FAU - Gravenhorst, Katja
AU  - Gravenhorst K
FAU - Eden, Tim O B
AU  - Eden TO
FAU - Young, Bridget
AU  - Young B
LA  - eng
GR  - G0800792/MRC_/Medical Research Council/United Kingdom
GR  - C19412/A6913/CRUK_/Cancer Research UK/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101022
PL  - England
TA  - BMC Med Res Methodol
JT  - BMC medical research methodology
JID - 100968545
SB  - IM
MH  - Adult
MH  - Attitude to Health
MH  - Child
MH  - Clinical Trials as Topic/ethics/*standards
MH  - Humans
MH  - Interviews as Topic
MH  - *Parents
MH  - Patient Selection/*ethics
MH  - Pediatrics/*standards
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma
MH  - *Professional-Family Relations
MH  - *Therapeutic Equipoise
MH  - United Kingdom
PMC - PMC2972295
EDAT- 2010/10/26 06:00
MHDA- 2011/06/10 06:00
CRDT- 2010/10/26 06:00
PHST- 2010/07/05 00:00 [received]
PHST- 2010/10/22 00:00 [accepted]
PHST- 2010/10/26 06:00 [entrez]
PHST- 2010/10/26 06:00 [pubmed]
PHST- 2011/06/10 06:00 [medline]
AID - 1471-2288-10-101 [pii]
AID - 10.1186/1471-2288-10-101 [doi]
PST - epublish
SO  - BMC Med Res Methodol. 2010 Oct 22;10:101. doi: 10.1186/1471-2288-10-101.


PMID- 20969761
OWN - NLM
STAT- MEDLINE
DCOM- 20110322
LR  - 20220331
IS  - 1471-2458 (Electronic)
IS  - 1471-2458 (Linking)
VI  - 10
DP  - 2010 Oct 22
TI  - An overview of ethical frameworks in public health: can they be supportive in the
      evaluation of programs to prevent overweight?
PG  - 638
LID - 10.1186/1471-2458-10-638 [doi]
AB  - BACKGROUND: The prevention of overweight sometimes raises complex ethical
      questions. Ethical public health frameworks may be helpful in evaluating programs
      or policy for overweight prevention. We give an overview of the purpose, form and
      contents of such public health frameworks and investigate to which extent they
      are useful for evaluating programs to prevent overweight and/or obesity. METHODS:
      Our search for frameworks consisted of three steps. Firstly, we asked experts in 
      the field of ethics and public health for the frameworks they were aware of.
      Secondly, we performed a search in Pubmed. Thirdly, we checked literature
      references in the articles on frameworks we found. In total, we thus found six
      ethical frameworks. We assessed the area on which the available ethical
      frameworks focus, the users they target at, the type of policy or intervention
      they propose to address, and their aim. Further, we looked at their structure and
      content, that is, tools for guiding the analytic process, the main ethical
      principles or values, possible criteria for dealing with ethical conflicts, and
      the concrete policy issues they are applied to. RESULTS: All frameworks aim to
      support public health professionals or policymakers. Most of them provide a set
      of values or principles that serve as a standard for evaluating policy. Most
      frameworks articulate both the positive ethical foundations for public health and
      ethical constraints or concerns. Some frameworks offer analytic tools for guiding
      the evaluative process. Procedural guidelines and concrete criteria for solving
      important ethical conflicts in the particular area of the prevention of
      overweight or obesity are mostly lacking. CONCLUSIONS: Public health ethical
      frameworks may be supportive in the evaluation of overweight prevention programs 
      or policy, but seem to lack practical guidance to address ethical conflicts in
      this particular area.
FAU - ten Have, Marieke
AU  - ten Have M
AD  - Department of Medical Ethics, Erasmus Medical Centre, Dr. Molewaterplein 50,
      Rotterdam, The Netherlands. m.tenhave@erasmusmc.nl
FAU - de Beaufort, Inez D
AU  - de Beaufort ID
FAU - Mackenbach, Johan P
AU  - Mackenbach JP
FAU - van der Heide, Agnes
AU  - van der Heide A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101022
PL  - England
TA  - BMC Public Health
JT  - BMC public health
JID - 100968562
SB  - IM
MH  - Ethics, Professional
MH  - Health Policy
MH  - Humans
MH  - Overweight/*prevention & control
MH  - *Program Evaluation
MH  - Public Health/*ethics
PMC - PMC2990740
EDAT- 2010/10/26 06:00
MHDA- 2011/03/23 06:00
CRDT- 2010/10/26 06:00
PHST- 2009/12/18 00:00 [received]
PHST- 2010/10/22 00:00 [accepted]
PHST- 2010/10/26 06:00 [entrez]
PHST- 2010/10/26 06:00 [pubmed]
PHST- 2011/03/23 06:00 [medline]
AID - 1471-2458-10-638 [pii]
AID - 10.1186/1471-2458-10-638 [doi]
PST - epublish
SO  - BMC Public Health. 2010 Oct 22;10:638. doi: 10.1186/1471-2458-10-638.


PMID- 20969745
OWN - NLM
STAT- MEDLINE
DCOM- 20110609
LR  - 20211020
IS  - 1471-2288 (Electronic)
IS  - 1471-2288 (Linking)
VI  - 10
DP  - 2010 Oct 22
TI  - New directions in childhood obesity research: how a comprehensive biorepository
      will allow better prediction of outcomes.
PG  - 100
LID - 10.1186/1471-2288-10-100 [doi]
AB  - BACKGROUND: Childhood obesity is associated with the early development of
      diseases such as type 2 diabetes and cardiovascular disease. Unfortunately, to
      date, traditional methods of research have failed to identify effective
      prevention and treatment strategies, and large numbers of children and
      adolescents continue to be at high risk of developing weight-related disease.
      AIM: To establish a unique 'biorepository' of data and biological samples from
      overweight and obese children, in order to investigate the complex 'gene x
      environment' interactions that govern disease risk. METHODS: The 'Childhood
      Overweight BioRepository of Australia' collects baseline environmental, clinical 
      and anthropometric data, alongside storage of blood samples for genetic,
      metabolic and hormonal profiles. Opportunities for longitudinal data collection
      have also been incorporated into the study design. National and international
      harmonization of data and sample collection will achieve required statistical
      power. RESULTS: Ethical approval in the parent site has been obtained and early
      data indicate a high response rate among eligible participants (71%) with a high 
      level of compliance for comprehensive data collection (range 56% to 97% for
      individual study components). Multi-site ethical approval is now underway.
      CONCLUSIONS: In time, it is anticipated that this comprehensive approach to data 
      collection will allow early identification of individuals most susceptible to
      disease, as well as facilitating refinement of prevention and treatment programs.
FAU - Sabin, Matthew A
AU  - Sabin MA
FAU - Clemens, Susan L
AU  - Clemens SL
FAU - Saffery, Richard
AU  - Saffery R
FAU - McCallum, Zoe
AU  - McCallum Z
FAU - Campbell, Michele W
AU  - Campbell MW
FAU - Kiess, Wieland
AU  - Kiess W
FAU - Crimmins, Nancy A
AU  - Crimmins NA
FAU - Woo, Jessica G
AU  - Woo JG
FAU - Leong, Gary M
AU  - Leong GM
FAU - Werther, George A
AU  - Werther GA
FAU - Ukoumunne, Obioha C
AU  - Ukoumunne OC
FAU - Wake, Melissa A
AU  - Wake MA
LA  - eng
PT  - Letter
PT  - Research Support, Non-U.S. Gov't
DEP - 20101022
PL  - England
TA  - BMC Med Res Methodol
JT  - BMC medical research methodology
JID - 100968545
SB  - IM
MH  - Adolescent
MH  - Australia
MH  - *Biomedical Research
MH  - Child
MH  - Child, Preschool
MH  - Comorbidity
MH  - Data Collection
MH  - *Databases, Factual
MH  - Humans
MH  - *Obesity/genetics
MH  - Overweight
MH  - Risk Factors
MH  - Weight Loss
PMC - PMC2984501
EDAT- 2010/10/26 06:00
MHDA- 2011/06/10 06:00
CRDT- 2010/10/26 06:00
PHST- 2010/05/14 00:00 [received]
PHST- 2010/10/22 00:00 [accepted]
PHST- 2010/10/26 06:00 [entrez]
PHST- 2010/10/26 06:00 [pubmed]
PHST- 2011/06/10 06:00 [medline]
AID - 1471-2288-10-100 [pii]
AID - 10.1186/1471-2288-10-100 [doi]
PST - epublish
SO  - BMC Med Res Methodol. 2010 Oct 22;10:100. doi: 10.1186/1471-2288-10-100.


PMID- 20969531
OWN - NLM
STAT- MEDLINE
DCOM- 20110225
LR  - 20101025
IS  - 1525-6073 (Electronic)
IS  - 0742-0528 (Linking)
VI  - 27
IP  - 9-10
DP  - 2010 Oct
TI  - Ethics and methods for biological rhythm research on animals and human beings.
PG  - 1911-29
LID - 10.3109/07420528.2010.516381 [doi]
AB  - This article updates the ethical standards and methods for the conduct of
      high-quality animal and human biological rhythm research, which should be
      especially useful for new investigators of the rhythms of life. The editors of
      Chronobiology International adhere to and endorse the Code of Conduct and Best
      Practice Guidelines of the Committee On Publication Ethics (COPE), which
      encourages communication of such updates at regular intervals in the journal. The
      journal accepts papers representing original work, no part of which was
      previously submitted for publication elsewhere, except as brief abstracts, as
      well as in-depth reviews. The majority of research papers published in
      Chronobiology International entails animal and human investigations. The editors 
      and readers of the journal expect authors of submitted manuscripts to have made
      an important contribution to the research of biological rhythms and related
      phenomena using ethical methods/procedures and unbiased, accurate, and honest
      reporting of findings. Authors of scientific papers are required to declare all
      potential conflicts of interest. The journal and its editors endorse compliance
      of investigators to the Guide for the Care and Use of Laboratory Animals of the
      Institute for Laboratory Animal Research of the National Research Council,
      relating to the conduct of ethical research on laboratory and other animals, and 
      the principles of the Declaration of Helsinki of the World Medical Association,
      relating to the conduct of ethical research on human beings. The peer review of
      manuscripts by Chronobiology International thus includes judgment as to whether
      or not the protocols and methods conform to ethical standards. Authors are
      expected to show mastery of the basic methods and procedures of biological rhythm
      research and proper statistical assessment of data, including the appropriate
      application of time series data analyses, as briefly reviewed in this article.
      The journal editors strive to consistently achieve high standards for the
      research of original and review papers reported in Chronobiology International,
      and current examples of expectations are presented herein.
FAU - Portaluppi, Francesco
AU  - Portaluppi F
AD  - International Society for Chronobiology, Hypertension Center, Department of
      Medicine, University Hospital S. Anna of Ferrara, Ferrara, Italy. prf@unife.it
FAU - Smolensky, Michael H
AU  - Smolensky MH
FAU - Touitou, Yvan
AU  - Touitou Y
LA  - eng
PT  - Journal Article
PL  - England
TA  - Chronobiol Int
JT  - Chronobiology international
JID - 8501362
SB  - IM
MH  - Animals
MH  - Animals, Laboratory
MH  - Authorship/standards
MH  - Bioethics/*trends
MH  - Chronobiology Discipline/standards
MH  - Confidentiality/standards
MH  - Conflict of Interest
MH  - Humans
MH  - Informed Consent/standards
MH  - Laboratory Animal Science/standards
MH  - Periodicals as Topic/standards
MH  - *Periodicity
MH  - Publishing/standards
MH  - Research/*standards
MH  - Research Support as Topic/standards
EDAT- 2010/10/26 06:00
MHDA- 2011/02/26 06:00
CRDT- 2010/10/26 06:00
PHST- 2010/10/26 06:00 [entrez]
PHST- 2010/10/26 06:00 [pubmed]
PHST- 2011/02/26 06:00 [medline]
AID - 10.3109/07420528.2010.516381 [doi]
PST - ppublish
SO  - Chronobiol Int. 2010 Oct;27(9-10):1911-29. doi: 10.3109/07420528.2010.516381.


PMID- 20968195
OWN - NLM
STAT- MEDLINE
DCOM- 20101207
LR  - 20211020
IS  - 1844-122X (Print)
IS  - 1844-122X (Linking)
VI  - 3
IP  - 2
DP  - 2010 Apr-Jun
TI  - Placebo effects in neurological diseases.
PG  - 114-21
AB  - There is an imperious need of redefining placebo effect in contemporary times.
      The effects of sham medical intervention, combined with a careful observation of 
      the natural evolution of a disease, could reveal the true efficiency and impact
      of active drugs. This interest is not driven only by a scientific curiosity, but 
      also by the pragmatic fact that the standard process of approving new medicines
      through supportive clinical trials requires a comparison against placebo. A
      complete understanding of the placebo effect should include both its
      psychological mechanisms and the underlying neurobiology. In contrast to other
      type of conditions, neurological disorders could provide specific clues in
      understanding the placebo effect, since the pathogenic mechanisms of different
      diseases might interfere with neuronal circuitry involved in the perception of
      disease symptoms. However, there are ethical considerations dictating the limits 
      of using placebo. This paper reviews recent articles about placebo effect, with
      an emphasis on its importance in several neurological conditions (Parkinson's
      disease, neuropathic pain, headache, multiple sclerosis, epilepsy), and intends
      to offer new insights on this major topic.
FAU - Dumitriu, Alina
AU  - Dumitriu A
AD  - Department of Neurology, University Hospital Bucharest, "Carol Davila" University
      of Medicine and Pharmacy, 169 Spl. Independentei, District 5, 050098 Bucharest,
      Romania.
FAU - Popescu, Bogdan O
AU  - Popescu BO
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Romania
TA  - J Med Life
JT  - Journal of medicine and life
JID - 101477617
SB  - IM
MH  - Epilepsy/drug therapy
MH  - Headache/drug therapy
MH  - Humans
MH  - Multiple Sclerosis/drug therapy
MH  - Nervous System Diseases/*drug therapy/physiopathology/psychology
MH  - Neuralgia/drug therapy
MH  - Parkinson Disease/drug therapy
MH  - *Placebo Effect
MH  - Randomized Controlled Trials as Topic/ethics
PMC - PMC3019048
EDAT- 2010/10/26 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/10/26 06:00
PHST- 2010/10/26 06:00 [entrez]
PHST- 2010/10/26 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - J Med Life. 2010 Apr-Jun;3(2):114-21.


PMID- 20966996
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20161125
IS  - 1476-5373 (Electronic)
IS  - 0007-0610 (Linking)
VI  - 209
IP  - 8
DP  - 2010 Oct 23
TI  - Ethical sourcing of dental instruments and materials.
PG  - 377-9
LID - 10.1038/sj.bdj.2010.925 [doi]
AB  - There is evidence that dental instruments and materials are being manufactured in
      the developing world under poor labour conditions. It is suggested that the level
      of awareness of the dental team with regard to this is raised and that a culture 
      of greater inquiry into the sourcing of instruments and materials is developed.
FAU - Kelly, P T
AU  - Kelly PT
AD  - General Dental Practitioner, Milford House, Weymouth, Dorset.
      pklocum@hotmail.co.uk
FAU - Bhutta, M
AU  - Bhutta M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br Dent J
JT  - British dental journal
JID - 7513219
RN  - 0 (Dental Materials)
SB  - IM
MH  - Dental Instruments/*ethics
MH  - *Dental Materials
MH  - Developing Countries/economics
MH  - Employment/ethics
MH  - Ethics, Business
MH  - *Ethics, Dental
MH  - European Union
MH  - Humans
MH  - Outsourced Services/ethics
MH  - Practice Management, Dental/*ethics
MH  - Social Responsibility
MH  - United Kingdom
MH  - Workplace
EDAT- 2010/10/23 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/10/23 06:00
PHST- 2010/07/12 00:00 [accepted]
PHST- 2010/10/23 06:00 [entrez]
PHST- 2010/10/23 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - sj.bdj.2010.925 [pii]
AID - 10.1038/sj.bdj.2010.925 [doi]
PST - ppublish
SO  - Br Dent J. 2010 Oct 23;209(8):377-9. doi: 10.1038/sj.bdj.2010.925.


PMID- 20966865
OWN - NLM
STAT- MEDLINE
DCOM- 20101130
LR  - 20101022
IS  - 0966-0461 (Print)
IS  - 0966-0461 (Linking)
VI  - 19
IP  - 15
DP  - 2010 Aug 12-Sep 8
TI  - The developing role of children's nurses in community palliative care.
PG  - 977-81
AB  - This article addresses some of the contemporary issues in relation to providing
      palliative care for children in Ireland, particularly focusing on the creation of
      the specialist palliative care nursing outreach posts. The recent publication of 
      an Irish national policy on palliative care for children with life-limiting
      illness is welcome news for paediatric nurses in Ireland. Children are valued
      members of society and have a right to receive quality health care and support
      appropriate to meet both children and the families' precise needs. However,
      community services for children with life-limiting illnesses remain inadequate,
      with many parents and families struggling to provide palliative care for children
      in the home. Currently, community nurses, who are not always registered
      children's nurses, are providing palliative care for children at the end of life.
      These nurses may not fully understand the specific needs of critically or
      chronically ill children and their families. In addition, there are no specific
      palliative care educational programmes in Ireland with regard to end-of-life care
      for children. The challenges of providing palliative care to children and their
      families in relation to symptom control, controversial ethical and legal issues, 
      and emotional and practical support, mean that advanced knowledge is required in 
      order to progress the agenda and thus provide excellence in children's palliative
      care in Ireland. It is important that the agenda is moved forward so that
      children and their families requiring palliative care and nursing support do not 
      suffer from a lack of professional provision for their needs.
FAU - O Brien, Irene
AU  - O Brien I
AD  - Our Lady's Children Hospital, Dublin.
FAU - Duffy, Anita
AU  - Duffy A
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Nurs
JT  - British journal of nursing (Mark Allen Publishing)
JID - 9212059
MH  - Child
MH  - *Community Health Nursing
MH  - Community-Institutional Relations
MH  - Health Education
MH  - Health Services Accessibility
MH  - Home Care Services
MH  - Humans
MH  - Ireland
MH  - *Nurse's Role
MH  - *Palliative Care
MH  - *Pediatric Nursing
MH  - Respite Care
EDAT- 2010/10/23 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/10/23 06:00
PHST- 2010/10/23 06:00 [entrez]
PHST- 2010/10/23 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.12968/bjon.2010.19.15.77694 [doi]
PST - ppublish
SO  - Br J Nurs. 2010 Aug 12-Sep 8;19(15):977-81. doi: 10.12968/bjon.2010.19.15.77694.


PMID- 20966557
OWN - NLM
STAT- MEDLINE
DCOM- 20110214
LR  - 20191210
IS  - 1998-3646 (Electronic)
IS  - 0255-0857 (Linking)
VI  - 28
IP  - 4
DP  - 2010 Oct-Dec
TI  - Evaluation of Calypte AWARE HIV-1/2 OMT antibody test as a screening test in an
      Indian setting.
PG  - 295-8
LID - 10.4103/0255-0857.71809 [doi]
AB  - PURPOSE: Integrated counselling and testing centres (ICTC) provide counselling
      and blood testing facilities for HIV diagnosis. Oral fluid tests provide an
      alternative for people who do not want blood to be drawn. Also, it avoids the
      risk of occupational exposure. The goal of this study was to evaluate the utility
      of Calypte AWARE HIV-1/2 OMT antibody test as a screening test in an Indian
      setting. MATERIALS AND METHODS: A cross-sectional study was carried out after
      ethics committee approval in 250 adult ICTC clients. Blood was collected and
      tested from these clients for HIV diagnosis as per routine policy and the results
      were considered as the gold standard. Also, after another written informed
      consent, oral fluid was collected from the clients and tested for the presence of
      HIV antibodies. Twenty five clients who had and 25 clients who had not completed 
      their secondary school education (Group A and Group B, respectively) were also
      asked to perform and interpret the test on their own and their findings and
      experiences were noted. RESULT: The sensitivity, specificity, PPV and NPV of the 
      oral fluid antibody test were 100%, 98.51%, 94.11% and 100%, respectively.
      Seventy six percent of clients preferred oral fluid testing. Group B found it
      difficult to perform the test as compared to Group A and this difference was
      statistically significant (P </= 0.05). CONCLUSION: Oral fluid testing can be
      used as a screening test for HIV diagnosis; however, confirmation of reactive
      results by blood-based tests is a must.
FAU - Ingole, N A
AU  - Ingole NA
AD  - Department of Microbiology, Seth GSMC & KEMH, Parel, Mumbai, India.
      nayanaingole@gmail.com
FAU - Mehta, P R
AU  - Mehta PR
FAU - Bande, R N
AU  - Bande RN
FAU - Paranjpe, S M
AU  - Paranjpe SM
FAU - Wanjare, S W
AU  - Wanjare SW
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - United States
TA  - Indian J Med Microbiol
JT  - Indian journal of medical microbiology
JID - 8700903
RN  - 0 (HIV Antibodies)
RN  - 0 (Reagent Kits, Diagnostic)
SB  - IM
MH  - AIDS Serodiagnosis/methods
MH  - Adult
MH  - Cross-Sectional Studies
MH  - HIV Antibodies/analysis/*blood
MH  - HIV Infections/*diagnosis/immunology/prevention & control/virology
MH  - HIV-1/*immunology
MH  - HIV-2/*immunology
MH  - Humans
MH  - India
MH  - Male
MH  - Mass Screening/*methods
MH  - Predictive Value of Tests
MH  - Reagent Kits, Diagnostic
MH  - Saliva/*immunology
MH  - Sensitivity and Specificity
EDAT- 2010/10/23 06:00
MHDA- 2011/02/15 06:00
CRDT- 2010/10/23 06:00
PHST- 2010/10/23 06:00 [entrez]
PHST- 2010/10/23 06:00 [pubmed]
PHST- 2011/02/15 06:00 [medline]
AID - IndianJMedMicrobiol_2010_28_4_295_71809 [pii]
AID - 10.4103/0255-0857.71809 [doi]
PST - ppublish
SO  - Indian J Med Microbiol. 2010 Oct-Dec;28(4):295-8. doi: 10.4103/0255-0857.71809.


PMID- 20966164
OWN - NLM
STAT- MEDLINE
DCOM- 20120116
LR  - 20110915
IS  - 1573-286X (Electronic)
IS  - 1079-0632 (Linking)
VI  - 23
IP  - 3
DP  - 2011 Sep
TI  - Boundaries and dual relationships.
PG  - 365-80
LID - 10.1177/1079063210381411 [doi]
AB  - Ethical standards are core components of practice standards and codes of conduct 
      for mental health practitioners. Practice standards and ethics related to
      boundaries are generally based on historical review, study of mental health
      services, and the impact of boundary crossing or boundary violations on clients
      receiving services. This article explores some common standards of ethical
      practice related to boundaries and dual or multiple relationships between mental 
      health professionals and clients. The underlying conceptual basis for these
      standards and examples of questions encountered in clinical practice with sexual 
      offenders are explored.
FAU - Sawyer, Steven
AU  - Sawyer S
AD  - steve@sawyersolutions.org
FAU - Prescott, David
AU  - Prescott D
LA  - eng
PT  - Journal Article
DEP - 20101021
PL  - United States
TA  - Sex Abuse
JT  - Sexual abuse : a journal of research and treatment
JID - 9506704
SB  - IM
MH  - Criminals/*psychology
MH  - Humans
MH  - Mental Health Services/*ethics
MH  - Professional-Patient Relations/*ethics
MH  - Sex Offenses/*psychology
EDAT- 2010/10/23 06:00
MHDA- 2012/01/17 06:00
CRDT- 2010/10/23 06:00
PHST- 2010/10/23 06:00 [entrez]
PHST- 2010/10/23 06:00 [pubmed]
PHST- 2012/01/17 06:00 [medline]
AID - 1079063210381411 [pii]
AID - 10.1177/1079063210381411 [doi]
PST - ppublish
SO  - Sex Abuse. 2011 Sep;23(3):365-80. doi: 10.1177/1079063210381411. Epub 2010 Oct
      21.


PMID- 20965872
OWN - NLM
STAT- MEDLINE
DCOM- 20110120
LR  - 20211020
IS  - 1438-8871 (Electronic)
IS  - 1438-8871 (Linking)
VI  - 12
IP  - 4
DP  - 2010 Oct 18
TI  - The establishment of an ethical guideline for genetic testing through citizen
      consensus via the Internet in Taiwan.
PG  - e47
LID - 10.2196/jmir.1467 [doi]
AB  - BACKGROUND: With the rapid advance of genetics, the application of genetic
      testing has become increasingly popular. Test results have had a tremendous
      impact on individuals who receive the test and his or her family. The ethical,
      legal, and social implications (ELSI) of genetic testing cannot be overlooked.
      The Internet is a potential tool for public engagement. OBJECTIVES: This study
      aimed at establishing ethical guidelines for genetic testing in Taiwan through a 
      participatory citizen consensus approach via the Internet. METHODS: The research 
      method used was a citizen consensus conference modified by an Internet
      application and the Delphi technique. The citizen consensus conference is one of 
      the public participation mechanisms. The draft ethical guidelines for genetic
      testing were written by an expert panel of 10. The Delphi technique was applied
      to a citizen panel recruited via the Internet until a consensus was reached. Our 
      research population was restricted to people who had Internet access. RESULTS:
      Included in the citizen panel were 100 individuals. A total of 3 individuals
      dropped out of the process. The citizen panel was exposed to the issues through
      Internet learning and sharing. In all, 3 rounds of anonymous questionnaires were 
      administered before a consensus was reached in terms of importance and
      feasibility. The result was ethical guidelines composed of 4 categories and 25
      items. The 4 categories encompassed decision making (6 items), management of
      tissue samples (5 items), release of results (8 items), and information flow (6
      items). On a scale of 1 to 10, the average (SD) importance score for the
      decision-making category was 9.41 (SD 0.58); for the management of tissue samples
      category, the average score was 9.62 (SD 0.49); for the release of results
      category, the average score was 9.34 (SD= 0.59); and for the information flow
      category, the average score was 9.6 (SD = 0.43). Exploratory analyses indicated
      that participants with higher education tended to attribute more importance to
      these guidelines. CONCLUSIONS: The resulting recommended ethical guidelines had 4
      categories and 25 items. We hope through the implementation of these guidelines
      that mutual trust can be established between health care profession and the
      general public with respect to genetic tests.
FAU - Lin, Chiou-Fen
AU  - Lin CF
AD  - Department of Nursing, Taipei Medical University, Shuang Ho Hospital, Taipei,
      Taiwan.
FAU - Lu, Meei-Shiow
AU  - Lu MS
FAU - Chung, Chun-Chih
AU  - Chung CC
FAU - Yang, Che-Ming
AU  - Yang CM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101018
PL  - Canada
TA  - J Med Internet Res
JT  - Journal of medical Internet research
JID - 100959882
SB  - IM
MH  - Adult
MH  - Attitude to Health
MH  - *Bioethical Issues
MH  - Community Participation/*statistics & numerical data
MH  - *Consensus
MH  - Female
MH  - Genetic Counseling/ethics
MH  - Genetic Predisposition to Disease
MH  - Genetic Testing/*ethics/statistics & numerical data
MH  - Genetics, Medical/ethics
MH  - Health Services Needs and Demand/*ethics/statistics & numerical data
MH  - Humans
MH  - Internet/*statistics & numerical data
MH  - Male
MH  - Middle Aged
MH  - Practice Guidelines as Topic
MH  - Public Opinion
MH  - Taiwan
MH  - Young Adult
PMC - PMC3056533
EDAT- 2010/10/23 06:00
MHDA- 2011/01/21 06:00
CRDT- 2010/10/23 06:00
PHST- 2010/01/12 00:00 [received]
PHST- 2010/05/25 00:00 [accepted]
PHST- 2010/04/12 00:00 [revised]
PHST- 2010/10/23 06:00 [entrez]
PHST- 2010/10/23 06:00 [pubmed]
PHST- 2011/01/21 06:00 [medline]
AID - v12i4e47 [pii]
AID - 10.2196/jmir.1467 [doi]
PST - epublish
SO  - J Med Internet Res. 2010 Oct 18;12(4):e47. doi: 10.2196/jmir.1467.


PMID- 20965112
OWN - NLM
STAT- MEDLINE
DCOM- 20120518
LR  - 20111010
IS  - 1872-7727 (Electronic)
IS  - 0720-048X (Linking)
VI  - 80
IP  - 2
DP  - 2011 Nov
TI  - MRI assessment of changes in liver iron deposition post-venesection.
PG  - 204-7
LID - 10.1016/j.ejrad.2010.05.010 [doi]
AB  - OBJECTIVE: The aim of this study was to determine if changes in hepatic iron
      content in patients with hemochromatosis pre- and post-venesection could be
      detected by changes in liver signal intensity with MRI. MATERIALS AND METHODS:
      The study was performed with institutional ethics approval and with informed
      consent. Gradient echo images were performed on 20 patients with hemochromatosis 
      pre- and post-venesection and 10 control subjects: gradient echo T1-weighted in- 
      and out-phases (4.54 (in)/2.27 (out), 167 [TE/TR], Flip 70 degrees ) and gradient
      echo T2* (5/18 [TE/TR], Flip 10 degrees ). The liver to muscle signal ratio was
      compared pre- and post-venesection. RESULTS: All MRI sequences showed significant
      correlation between the liver to muscle signal intensity ratio and the serum
      ferritin pre-venesection [r=-0.70, -0.65, -0.74, -0.72, in/out/T2*r/T2*,
      respectively]. There was a significant increase on all sequences in the liver to 
      muscle signal intensity ratio post-venesection (p<0.001). The control group and
      patients post-venesection had almost identical liver to muscle signal intensity
      ratios. CONCLUSION: The reduction in liver signal intensity caused by iron excess
      in hemochromatosis returns to normal post-venesection. Measurement of liver to
      muscle signal intensity ratios may be a useful tool in assessing treatment
      response in iron overload states.
CI  - Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Beddy, P
AU  - Beddy P
AD  - Department of Radiology, University of Cambridge, Addenbrooke's Hospital, Hills
      Road, Cambridge CB2 0QQ, UK. pbeddy@eircom.net
FAU - McCann, J
AU  - McCann J
FAU - Ahern, M
AU  - Ahern M
FAU - Norris, S
AU  - Norris S
FAU - Keogan, M
AU  - Keogan M
LA  - eng
PT  - Journal Article
DEP - 20100608
PL  - Ireland
TA  - Eur J Radiol
JT  - European journal of radiology
JID - 8106411
RN  - 9007-73-2 (Ferritins)
SB  - IM
MH  - Case-Control Studies
MH  - Female
MH  - Ferritins/blood
MH  - Hemochromatosis/*pathology/*therapy
MH  - Humans
MH  - Iron Overload/*diagnosis/*therapy
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - *Phlebotomy
MH  - Prospective Studies
MH  - Treatment Outcome
EDAT- 2010/10/23 06:00
MHDA- 2012/05/19 06:00
CRDT- 2010/10/23 06:00
PHST- 2010/03/02 00:00 [received]
PHST- 2010/05/08 00:00 [revised]
PHST- 2010/05/11 00:00 [accepted]
PHST- 2010/10/23 06:00 [entrez]
PHST- 2010/10/23 06:00 [pubmed]
PHST- 2012/05/19 06:00 [medline]
AID - S0720-048X(10)00210-X [pii]
AID - 10.1016/j.ejrad.2010.05.010 [doi]
PST - ppublish
SO  - Eur J Radiol. 2011 Nov;80(2):204-7. doi: 10.1016/j.ejrad.2010.05.010. Epub 2010
      Jun 8.


PMID- 20964996
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20131121
IS  - 0213-4853 (Print)
IS  - 0213-4853 (Linking)
VI  - 25
IP  - 8
DP  - 2010 Oct
TI  - [Cell therapy in amyotrophic lateral sclerosis: science and controversy].
PG  - 467-9
AB  - Stem cell therapy is seen as a possible alternative for the treatment of
      different degenerative diseases, among which includes amyotrophic lateral
      sclerosis (ALS). Despite there being basic research works with this therapy in
      ALS, the mechanism of action of the implanted cells are still unclear. It is also
      unclear which type of cells to use (bone marrow, fat, dental pulp, etc.), or the 
      most ideal administration route. Furthermore, clinical trials with mesenchymal
      stem cells are not very conclusive, therefore it has not been convincingly
      established as an alternative therapy in ALS or any other neurodegenerative
      disease. Despite the scientific evidence, several clinical trials have been
      conducted in the last few years that offer stem cell treatments for
      neurodegenerative diseases, giving rise to what is known as "cellular tourism".
      This phenomenon has set off alarms and reactions in the scientific community. The
      application of these therapies must be performed following the good clinical
      practice guidelines in research, evidence based methodology and international
      ethical and scientific recommendations.
FAU - Galan, L
AU  - Galan L
AD  - Unidad de ELA, Servicio de Neurologia, Hospital Clinico San Carlos, Madrid,
      Espana.
FAU - Guerrero-Sola, A
AU  - Guerrero-Sola A
FAU - Gomez-Pinedo, U
AU  - Gomez-Pinedo U
FAU - Matias-Guiu, J
AU  - Matias-Guiu J
LA  - spa
PT  - Editorial
PT  - English Abstract
TT  - Terapia celular en la esclerosis lateral amiotrofica: ciencia y controversia.
PL  - Spain
TA  - Neurologia
JT  - Neurologia (Barcelona, Spain)
JID - 9005460
SB  - IM
MH  - Amyotrophic Lateral Sclerosis/*surgery
MH  - *Cell- and Tissue-Based Therapy
MH  - Clinical Trials as Topic/ethics/standards
MH  - Humans
MH  - Neurodegenerative Diseases/surgery
MH  - *Stem Cell Transplantation/ethics/standards
EDAT- 2010/10/23 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/10/23 06:00
PHST- 2010/10/23 06:00 [entrez]
PHST- 2010/10/23 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - 13167408 [pii]
PST - ppublish
SO  - Neurologia. 2010 Oct;25(8):467-9.


PMID- 20964990
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20220321
IS  - 0213-4853 (Print)
IS  - 0213-4853 (Linking)
VI  - 25
IP  - 7
DP  - 2010 Sep
TI  - [Global adherence project to disease-modifying therapies in patients with
      relapsing multiple sclerosis: 2-year interim results].
PG  - 435-42
AB  - BACKGROUND: In this article we report adherence data from the first 2 years in a 
      subset of patients from the Global Adherence Project (GAP; n=2,648) in Spain.
      METHODS: A questionnaire assessing adherence to Disease-modifying therapies
      (DMTs), was distributed annually to patients and their treating neurologists.
      Non-adherence was defined as missing a DMT injection or changing a dose in the
      four weeks prior to completing the survey. Patients signed informed consent and
      Ethics Committees approved annual follow-ups, visit 1 (V1) and visit 2 (V2) in 15
      out of 18 centres in Spain. RESULTS: A total of 254 patients were enrolled in
      Spain. Patients had a mean age of 37.9 years and 70.4% were female, and had been 
      on their treatment for a median time of 28 months, and the overall adherence rate
      was 85.4%. Patients taking intramuscular interferon beta (IFNB)-1a (Avonex(R))
      were significantly more adherent (94.6%) compared with patients taking
      subcutaneous (s.c.) IFNB-1a 22.g (Rebif(R)22) (79.1%; p=0.0064), s.c. IFNB-1a
      44.g (Rebif(R)44) (79.6%; p=0.0064) and glatiramer acetate (GA) (82.7%;
      p=0.0184). At V1 (n=142), the overall adherence rate was 86.6% and patients on
      Avonex(R) were significantly more adherent than patients on Rebif(R)22 (93.9%
      versus 66.7%; p=0.0251). At V2 (n=131), the overall adherence rate was 82.4%
      (Avonex(R), 87.5%; Rebif(R)22, 80%; Rebif(R)44, 77.8%; Betaferon(R), 85.2%, and
      Copaxone(R), 80%) without significant differences. CONCLUSIONS: Adherence
      remained high over the first 2 years of the study. It was highest with Avonex(R),
      being significant on first assessment, after 40.5 months of therapy, on average
      compared with other DMTs and at year 1 compared with Rebif(R)22.
FAU - Arroyo, E
AU  - Arroyo E
AD  - Biogen Idec Iberia, S.L., Madrid, Espana.
FAU - Grau, C
AU  - Grau C
FAU - Ramo, C
AU  - Ramo C
FAU - Parra, J
AU  - Parra J
FAU - Sanchez-Solino, O
AU  - Sanchez-Solino O
CN  - por el grupo espanol del estudio GAP
LA  - spa
PT  - Clinical Trial, Phase IV
PT  - English Abstract
PT  - Journal Article
PT  - Multicenter Study
TT  - Estudio global de adherencia a los tratamientos inmunomoduladores en pacientes
      con esclerosis multiple remitente recidivante: resultados a 2 anos.
PL  - Spain
TA  - Neurologia
JT  - Neurologia (Barcelona, Spain)
JID - 9005460
RN  - 0 (Adjuvants, Immunologic)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Peptides)
RN  - 145155-23-3 (Interferon beta-1b)
RN  - 5M691HL4BO (Glatiramer Acetate)
RN  - 77238-31-4 (Interferon-beta)
RN  - XRO4566Q4R (Interferon beta-1a)
SB  - IM
MH  - Adjuvants, Immunologic/administration & dosage/*therapeutic use
MH  - Adult
MH  - Female
MH  - Glatiramer Acetate
MH  - Humans
MH  - Immunosuppressive Agents/*therapeutic use
MH  - Interferon beta-1a
MH  - Interferon beta-1b
MH  - Interferon-beta/administration & dosage/therapeutic use
MH  - Middle Aged
MH  - Multiple Sclerosis, Relapsing-Remitting/*drug therapy/*psychology
MH  - *Patient Compliance
MH  - Peptides/therapeutic use
MH  - Retrospective Studies
MH  - Spain
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
EDAT- 2010/10/23 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/10/23 06:00
PHST- 2010/10/23 06:00 [entrez]
PHST- 2010/10/23 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - 13156052 [pii]
PST - ppublish
SO  - Neurologia. 2010 Sep;25(7):435-42.


PMID- 20964840
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20211020
IS  - 1472-6920 (Electronic)
IS  - 1472-6920 (Linking)
VI  - 10
DP  - 2010 Oct 21
TI  - Attitudes of undergraduate health science students towards patients with
      intellectual disability, substance abuse, and acute mental illness: a
      cross-sectional study.
PG  - 71
LID - 10.1186/1472-6920-10-71 [doi]
AB  - BACKGROUND: There is a long history of certain medical conditions being
      associated with stigma, stereotypes, and negative attitudes. Research has shown
      that such attitudes can have a detrimental effect on patients presenting with
      stigmatised medical conditions and can even flow on to impact their family. The
      objective of this study was to measure the attitudes of undergraduate students
      enrolled in six different health-related courses at Monash University toward
      patients with intellectual disability, substance abuse, and acute mental illness.
      METHODS: A convenience sample of undergraduate students enrolled in six
      health-related courses in first, second and third years at Monash University were
      surveyed. The Medical Condition Regard Scale--a valid and reliable, self-report
      measure of attitudes--was administered to students along with a brief demographic
      form. Mean scores, t-tests, and ANOVA were used to analyse student attitudes.
      Ethics approval was granted. RESULTS: 548 students participated. Statistically
      significant differences were found between the courses (p = 0.05), year of the
      course (p = 0.09), and gender (p = 0.04) for the medical condition of
      intellectual disability. There was no statistically significant difference
      between the courses, year of the course, gender, and age group for substance
      abuse or acute mental illness conditions. CONCLUSION: The findings suggest that
      students in undergraduate health-related courses, as a group, have a strong
      regard for patients with intellectual disability and some regard for patients
      with acute mental illness, but not for patients presenting with substance abuse
      problems.
FAU - Boyle, Malcolm J
AU  - Boyle MJ
AD  - Department of Community Emergency Health and Paramedic Practice, Monash
      University, PO Box 527, Frankston 3199, Victoria, Australia. Mal.Boyle@monash.edu
FAU - Williams, Brett
AU  - Williams B
FAU - Brown, Ted
AU  - Brown T
FAU - Molloy, Andrew
AU  - Molloy A
FAU - McKenna, Lisa
AU  - McKenna L
FAU - Molloy, Elizabeth
AU  - Molloy E
FAU - Lewis, Belinda
AU  - Lewis B
LA  - eng
PT  - Journal Article
DEP - 20101021
PL  - England
TA  - BMC Med Educ
JT  - BMC medical education
JID - 101088679
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Allied Health Personnel/education
MH  - Analysis of Variance
MH  - Cross-Sectional Studies
MH  - Curriculum
MH  - *Education, Premedical
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - *Intellectual Disability
MH  - Male
MH  - *Mental Disorders
MH  - Prejudice
MH  - Psychometrics
MH  - Students/*psychology
MH  - *Substance-Related Disorders
MH  - Surveys and Questionnaires
MH  - Young Adult
PMC - PMC2972293
EDAT- 2010/10/23 06:00
MHDA- 2011/01/07 06:00
CRDT- 2010/10/23 06:00
PHST- 2010/06/09 00:00 [received]
PHST- 2010/10/21 00:00 [accepted]
PHST- 2010/10/23 06:00 [entrez]
PHST- 2010/10/23 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
AID - 1472-6920-10-71 [pii]
AID - 10.1186/1472-6920-10-71 [doi]
PST - epublish
SO  - BMC Med Educ. 2010 Oct 21;10:71. doi: 10.1186/1472-6920-10-71.


PMID- 20964764
OWN - NLM
STAT- MEDLINE
DCOM- 20110217
LR  - 20131121
IS  - 1460-9592 (Electronic)
IS  - 1155-5645 (Linking)
VI  - 20
IP  - 11
DP  - 2010 Nov
TI  - A novel isotonic-balanced electrolyte solution with 1% glucose for intraoperative
      fluid therapy in children: results of a prospective multicentre observational
      post-authorization safety study (PASS).
PG  - 977-81
LID - 10.1111/j.1460-9592.2010.03428.x [doi]
AB  - BACKGROUND: The recommendations for intraoperative fluid therapy in children have
      been adapted from hypotonic to isotonic electrolyte solutions with lower glucose 
      concentrations (1-2.5% instead of 5%) to avoid hyponatremia and hyperglycemia.
      OBJECTIVE: The objective of this prospective multicentre observational
      post-authorization safety study was to evaluate the intraoperative use of a novel
      isotonic-balanced electrolyte solution with 1% glucose (BS-G1) with a particular 
      focus on changes in acid-base status, electrolyte and glucose concentrations.
      METHODS: Following local ethics committee approval, pediatric patients aged up to
      4 years with an ASA risk score of I-III undergoing intraoperative administration 
      of BS-G1 were enrolled. Patient demographics, the performed procedure, adverse
      drug reactions, hemodynamic data, and the results of blood gas analysis before
      and after infusion were documented with a focus on changes in acid-base status,
      electrolyte and glucose concentrations. RESULTS: In 107 patients (ASA I-III; age 
      16.2 +/- 15.4, range day of birth to 47.7 months; body weight 8.8 +/- 4.8, range 
      1.6-18.8 kg), the mean volume infused was 20 +/- 12.6 (range 3.6-83.3) ml.kg(-1) 
      BS-G1. During the infusion, hemoglobin, hematocrit, anion gap, strong ion
      difference, and calcium decreased and chloride and glucose increased
      significantly within the physiologic range. All other measured parameters
      including sodium, bicarbonate, base excess, and lactate remained stable. Neither 
      hypoglycemia (glucose <2.5 mmol.l(-1) ) nor hyperglycemia (glucose >10 mmol.l(-1)
      ) was documented after BS-G1 infusion. No adverse drug reactions were reported.
      CONCLUSION: The studied isotonic-balanced electrolyte solution with 1% glucose
      helps to avoid perioperative acid-base imbalance, hyponatremia, hyperglycemia,
      and ketoacidosis in infants and toddlers and may therefore enhance patient
      safety.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Sumpelmann, Robert
AU  - Sumpelmann R
AD  - Medizinische Hochschule Hannover, Klinik fur Anasthesiologie und
      Intensivmedizin-OE 8050, Hannover, Germany. suempelmann.robert@mh-hannover.de
FAU - Mader, Thomas
AU  - Mader T
FAU - Eich, Christoph
AU  - Eich C
FAU - Witt, Lars
AU  - Witt L
FAU - Osthaus, Wilhelm A
AU  - Osthaus WA
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - France
TA  - Paediatr Anaesth
JT  - Paediatric anaesthesia
JID - 9206575
RN  - 0 (Blood Glucose)
RN  - 0 (Electrolytes)
RN  - 0 (Hypotonic Solutions)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Acid-Base Equilibrium/drug effects
MH  - Blood Glucose/metabolism
MH  - Child, Preschool
MH  - Electrolytes/administration & dosage/blood/chemistry
MH  - Female
MH  - *Fluid Therapy
MH  - Glucose/administration & dosage/chemistry
MH  - Humans
MH  - Hypotonic Solutions/*adverse effects/chemistry/*therapeutic use
MH  - Infant
MH  - Infant, Newborn
MH  - Infusions, Intravenous
MH  - Intraoperative Care
MH  - Male
MH  - Prospective Studies
MH  - Safety
EDAT- 2010/10/23 06:00
MHDA- 2011/02/18 06:00
CRDT- 2010/10/23 06:00
PHST- 2010/10/23 06:00 [entrez]
PHST- 2010/10/23 06:00 [pubmed]
PHST- 2011/02/18 06:00 [medline]
AID - 10.1111/j.1460-9592.2010.03428.x [doi]
PST - ppublish
SO  - Paediatr Anaesth. 2010 Nov;20(11):977-81. doi: 10.1111/j.1460-9592.2010.03428.x.


PMID- 20964481
OWN - NLM
STAT- MEDLINE
DCOM- 20110601
LR  - 20191210
IS  - 2152-4998 (Electronic)
IS  - 2152-4971 (Linking)
VI  - 13
IP  - 1
DP  - 2011 Feb
TI  - Generation of healthy cloned mice using enucleated cryopreserved oocytes.
PG  - 7-11
LID - 10.1089/cell.2010.0059 [doi]
AB  - The successful generation of cloned animals and the establishment of embryonic
      stem (ES) cell lines from somatic cells suggest that these techniques may be used
      in human regenerative medicine. However, the fact that oocytes must be donated by
      women undergoing infertility treatment remains a fundamental ethical objection,
      as they might be concerned about the potential exploitation of their genome.
      Here, we investigated the reprogramming potential of enucleated and cryopreserved
      oocytes for the development of full-term cloned mice. BDF1 strain mouse oocytes
      were cryopreserved at metaphase II, before and after enucleation. After thawing, 
      cumulus cell nuclei were microinjected to generate clones. Although the rate of
      development of cloned embryos to the blastocyst stage using the treated oocytes
      was lower than that obtained using fresh oocytes, three live pups were delivered 
      after embryo transfer into pseudopregnant females (0.4% of the oocytes used).
      Thus, although cryopreservation reduces the potential of oocytes, these cells
      retain the ability to support the full-term development of cloned embryos. In
      addition, the removal of DNA from human oocytes may alleviate the ethical and
      psychological problems for women who are undergoing infertility treatment and are
      considering oocyte donation for research or therapeutic purposes.
FAU - Hirata, Shuji
AU  - Hirata S
AD  - Department of Obstetrics and Gynecology, Interdisciplinary Graduate School of
      Medicine and Engineering, University of Yamanashi , Chuo, Yamanashi, Japan.
FAU - Fukasawa, Hiroko
AU  - Fukasawa H
FAU - Wakayama, Sayaka
AU  - Wakayama S
FAU - Wakayama, Teruhiko
AU  - Wakayama T
FAU - Hoshi, Kazuhiko
AU  - Hoshi K
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101021
PL  - United States
TA  - Cell Reprogram
JT  - Cellular reprogramming
JID - 101528176
SB  - IM
MH  - Animals
MH  - *Cell Nucleus
MH  - Cloning, Organism/*methods
MH  - *Cryopreservation
MH  - Embryo, Mammalian
MH  - Female
MH  - Humans
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred DBA
MH  - *Nuclear Transfer Techniques
MH  - Oocytes/*cytology
EDAT- 2010/10/23 06:00
MHDA- 2011/06/02 06:00
CRDT- 2010/10/23 06:00
PHST- 2010/10/23 06:00 [entrez]
PHST- 2010/10/23 06:00 [pubmed]
PHST- 2011/06/02 06:00 [medline]
AID - 10.1089/cell.2010.0059 [doi]
PST - ppublish
SO  - Cell Reprogram. 2011 Feb;13(1):7-11. doi: 10.1089/cell.2010.0059. Epub 2010 Oct
      21.


PMID- 20964264
OWN - NLM
STAT- MEDLINE
DCOM- 20101130
LR  - 20191111
IS  - 0093-0334 (Print)
IS  - 0093-0334 (Linking)
VI  - 40
IP  - 5
DP  - 2010 Sep-Oct
TI  - Against one-size-fits-all research ethics.
PG  - 10-1
FAU - Meyer, Michelle N
AU  - Meyer MN
AD  - Petrie-Flom Center for Health Law Policy, Biotechnology, and Bioethics, Harvard
      Law School, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Hastings Cent Rep
JT  - The Hastings Center report
JID - 0410447
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Humans
MH  - Informed Consent
MH  - National Institutes of Health (U.S.)
MH  - *Organizational Policy
MH  - *Stem Cells
MH  - United States
EDAT- 2010/10/23 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/10/23 06:00
PHST- 2010/10/23 06:00 [entrez]
PHST- 2010/10/23 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1353/hcr.2010.0015 [doi]
PST - ppublish
SO  - Hastings Cent Rep. 2010 Sep-Oct;40(5):10-1. doi: 10.1353/hcr.2010.0015.


PMID- 20964106
OWN - NLM
STAT- MEDLINE
DCOM- 20101129
LR  - 20151119
IS  - 0870-2551 (Print)
IS  - 0870-2551 (Linking)
VI  - 29
IP  - 6
DP  - 2010 Jun
TI  - Knowledge, behavior and ethical responsibility of health professionals with
      regard to smoking.
PG  - 923-46
AB  - OBJECTIVE: This is the first study after the implementation of a more restrictive
      Tobacco Law in Portugal, carried out in collaboration with the Program for
      Prevention and Treatment of Smoking of the Northern Region Health Authority. The 
      aim of the study was to characterize the attitudes and practices of health
      professionals with regard to tobacco consumption, given their importance in
      smoking reduction. The high prevalence of risk factors associated with
      circulatory diseases, particularly smoking, highlights the need for preventive
      measures. METHODS: This was a cross-sectional study assessing knowledge of the
      harmful effects of tobacco consumption and exposure to environmental tobacco
      smoke, ethical and professional behavior, and agreement with tobacco control
      measures. Participants were 101 physicians and 524 nurses from the primary health
      centers (PHCs) and Hospital S. Joao in the city of Porto. RESULTS: Smoking rates 
      of 23.1% and 13.0% were found among nurses and physicians, respectively. There
      was a lower proportion of smokers in PHCs (14.5% vs. 23.9%, p = 0.014). Most
      participants agreed with prohibition of smoking inside and outside the building
      (70.7% vs. 53.3%), but smokers were more skeptical regarding the benefits,
      especially nurses. Knowledge of the consequences of tobacco consumption and
      environmental tobacco smoke was reasonable, but 40.0% of physicians and only
      26.5% of nurses did not agree that ventilation systems can eliminate tobacco
      smoke (p = 0.009). Most participants acknowledged the inappropriateness of
      smoking in the presence of patients. In PHCs there was a higher percentage of
      health professionals who saw themselves as role models (80.6% vs. 66.7%, p =
      0.001), and of nurses who agreed with the inappropriateness of smoking in the
      presence of the public (61.9% vs. 42.3%, p = 0.001). Health care professionals
      supported tobacco control programs, although smokers were less supportive. In
      PHCs there was a higher percentage of professionals who received training on
      tobacco, and this appears to have had some impact on nurses' belief that they are
      seen as role models (OR = 2.431, p = 0.024). DISCUSSION AND CONCLUSIONS: These
      findings support the need for new campaigns to reduce smoking among health care
      professionals. The reasons for their skepticism concerning their ethical
      responsibility must be clarified. Greater investment is required in training on
      tobacco for pre- and post-graduate health professionals, in order to increase
      their awareness of the importance of their role in reducing tobacco consumption
      in society.
FAU - Ramos, Marisa Cunha Prada
AU  - Ramos MC
AD  - UAG de Cirurgia - Servico de Urologia, Hospital de S. Joao, Porto, Portugal.
FAU - Vinagre, Sergio
AU  - Vinagre S
FAU - Cardoso, Margarida Fonseca
AU  - Cardoso MF
LA  - eng
LA  - por
PT  - Journal Article
PT  - Multicenter Study
PL  - Portugal
TA  - Rev Port Cardiol
JT  - Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de
      Cardiologia = Portuguese journal of cardiology : an official journal of the
      Portuguese Society of Cardiology
JID - 8710716
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Health Personnel/*ethics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Smoking
MH  - Surveys and Questionnaires
EDAT- 2010/10/23 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/10/23 06:00
PHST- 2010/10/23 06:00 [entrez]
PHST- 2010/10/23 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - Rev Port Cardiol. 2010 Jun;29(6):923-46.


PMID- 20964086
OWN - HMD
STAT- MEDLINE
DCOM- 20101230
LR  - 20191027
IS  - 0891-9356 (Print)
VI  - 65
IP  - 2
DP  - 2010
TI  - "This immense expense of art": George Eliot and John Ruskin on consumption and
      the limits of sympathy.
PG  - 214-45
AB  - This essay attempts to better our understanding of George Eliot's conservatism by
      examining a body of ideas about consumption and moral obligation that she and
      John Ruskin share. I use a discussion of consumer ethics to explore the moral
      logic of their conservatism by examining the role of the aesthetic within it.
      Economic consumption and the aesthetic are subjects inextricably connected, not
      just because the discourses of political economy and aesthetics have a shared
      origin in eighteenth-century moral philosophy, but also because the discourse of 
      aesthetics has long served to legitimize select modes and acts of consumption. By
      marking out a limit where one may reasonably cease to sympathize and instead
      devote energy (and money) to personal gratification, the treatment of consumption
      in George Eliot's Middlemarch (1871) offers an important articulation of moral
      thought. Eliot suggests that aesthetic pleasure can make consumption morally
      defensible, but she also anticipates Pierre Bourdieu's critique of the aesthetic:
      her novel represents both the display of cultural capital and the exercise of the
      aesthetic disposition as ways of maintaining social and economic hierarchies. She
      thus at once critiques and participates in the system within which the aesthetic 
      functions to preserve social and political stasis. Using John Ruskin's economic
      writings to expose Middlemarch as a novel of consumer ethics, this essay examines
      Eliot's representation of personal economic consumption as an emergent mode of
      social and political agency that might operate productively within that stasis.
FAU - Coit, Emily
AU  - Coit E
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - Ninet Century Lit
JT  - Nineteenth-century literature
JID - 101522934
MH  - Commerce/economics/education/history
MH  - *Community Participation/economics/history/psychology
MH  - *Esthetics/education/history/psychology
MH  - *Hierarchy, Social/history
MH  - History, 19th Century
MH  - Household Products/history
MH  - *Literature/history
MH  - *Moral Obligations
MH  - Pleasure
MH  - *Social Mobility/economics/history
EDAT- 2010/10/23 06:00
MHDA- 2010/12/31 06:00
CRDT- 2010/10/23 06:00
PHST- 2010/10/23 06:00 [entrez]
PHST- 2010/10/23 06:00 [pubmed]
PHST- 2010/12/31 06:00 [medline]
AID - 10.1525/ncl.2010.65.2.214 [doi]
PST - ppublish
SO  - Ninet Century Lit. 2010;65(2):214-45. doi: 10.1525/ncl.2010.65.2.214.


PMID- 20964058
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20190911
IS  - 0080-6234 (Print)
IS  - 0080-6234 (Linking)
VI  - 44
IP  - 3
DP  - 2010 Sep
TI  - [Ageing and dementia: what do community health workers know?].
PG  - 782-8
AB  - The objective of this qualitative study was to assess the knowledge of community 
      health workers (CHW) with respect to aging and dementia, with the purpose of
      assisting the implantation of caregiving services focused on dementia, in a city 
      in the State of Sao Paulo. All ethical guidelines were followed. In all, 51 CHW
      were evaluated. Semi-structured interviews were conducted. The data analysis was 
      based on content analysis. In response to the question, What does elderly mean,
      for you?, the majority of the workers associated old age with chronologically
      advanced age and with negative aspects of aging, such as physical and social
      dependence. With respect to the concept of dementia, the majority of those
      interviewed defined dementia as a biological problem that affects the brain,
      compromising memory functions and resulting in dependency. The results
      demonstrate the need for an educational program for CHW, in the area of
      gerontology.
FAU - Fernandes, Heloise da Costa Lima
AU  - Fernandes Hda C
AD  - Escola de Enfermagem da Universidade de Sao Paulo, Brasil.
      heloisefernandes@usp.br
FAU - Pavarini, Sofia Cristina Iost
AU  - Pavarini SC
FAU - Barham, Elizabeth Joan
AU  - Barham EJ
FAU - de Mendiondo, Mariza Silvana Zazzetta
AU  - de Mendiondo MS
FAU - Luchesi, Bruna Moretti
AU  - Luchesi BM
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Envelhecimento e demencia: o que sabem os Agentes Comunitarios de Saude?
PL  - Brazil
TA  - Rev Esc Enferm USP
JT  - Revista da Escola de Enfermagem da U S P
JID - 0242726
MH  - Adult
MH  - *Aging
MH  - Brazil
MH  - Community Health Workers/*education
MH  - Cross-Sectional Studies
MH  - *Dementia
MH  - Female
MH  - Humans
MH  - Male
EDAT- 2010/10/23 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/10/23 06:00
PHST- 2010/10/23 06:00 [entrez]
PHST- 2010/10/23 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - S0080-62342010000300033 [pii]
AID - 10.1590/s0080-62342010000300033 [doi]
PST - ppublish
SO  - Rev Esc Enferm USP. 2010 Sep;44(3):782-8. doi: 10.1590/s0080-62342010000300033.


PMID- 20963969
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20101021
IS  - 0038-0814 (Print)
IS  - 0038-0814 (Linking)
IP  - 748
DP  - 2010 Sep
TI  - [Stigma and public health].
PG  - 18-20
AB  - Illnesses have always nourished phenomena of stigmatization, to which public
      health has occasionally contributed. This observation remains true today, in
      particular for risk-taking behaviour, and signals the emergence of a new
      preventive strategy: stigmatizing for encouraging behaviour change more greatly
      But does this strategy not give rise to ethical issues? And is its preventive
      effectiveness guaranteed?
FAU - Peretti-Watel, Patrick
AU  - Peretti-Watel P
AD  - Institut national de la sante et de la recherche medicale Inserm, Marseille.
      patrick.peretti-watel@inserm.fr
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Stigmate et sante publique.
PL  - France
TA  - Soins
JT  - Soins; la revue de reference infirmiere
JID - 20910580R
MH  - *Attitude to Health
MH  - Humans
MH  - Morals
MH  - Prejudice
MH  - Public Health/*ethics
MH  - Risk-Taking
MH  - Smoking/psychology
MH  - *Stereotyping
EDAT- 2010/10/23 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/10/23 06:00
PHST- 2010/10/23 06:00 [entrez]
PHST- 2010/10/23 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
PST - ppublish
SO  - Soins. 2010 Sep;(748):18-20.


PMID- 20963333
OWN - NLM
STAT- MEDLINE
DCOM- 20110204
LR  - 20170225
IS  - 1808-8686 (Electronic)
IS  - 1808-8686 (Linking)
VI  - 76
IP  - 5
DP  - 2010 Sep-Oct
TI  - Ethics in scientific publications: the double copyright problem.
PG  - 543
LID - S1808-86942010000500001 [pii]
FAU - Miziara, Ivan D
AU  - Miziara ID
LA  - eng
LA  - por
PT  - Editorial
PL  - Brazil
TA  - Braz J Otorhinolaryngol
JT  - Brazilian journal of otorhinolaryngology
JID - 101207337
SB  - IM
MH  - Brazil
MH  - Copyright/*ethics
MH  - Publications/*ethics
MH  - Publishing/ethics
MH  - Scientific Misconduct
EDAT- 2010/10/22 06:00
MHDA- 2011/02/05 06:00
CRDT- 2010/10/22 06:00
PHST- 2010/10/22 06:00 [entrez]
PHST- 2010/10/22 06:00 [pubmed]
PHST- 2011/02/05 06:00 [medline]
AID - S1808-8694(15)30906-X [pii]
PST - ppublish
SO  - Braz J Otorhinolaryngol. 2010 Sep-Oct;76(5):543.


PMID- 20963261
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20191210
IS  - 1680-5348 (Electronic)
IS  - 1020-4989 (Linking)
VI  - 28
IP  - 3
DP  - 2010 Sep
TI  - United States-Mexico Border Diabetes Prevalence Survey: lessons learned from
      implementation of the project.
PG  - 151-8
LID - S1020-49892010000900004 [pii]
AB  - This paper reviews and discusses the main procedures and policies that need to be
      followed when designing and implementing a binational survey such as the United
      States of America (U.S.)-Mexico Border Diabetes Prevalence Study that took place 
      between 2001 and 2002. The main objective of the survey was to determine the
      prevalence of diabetes in the population 18 years of age or older along
      U.S.-Mexico border counties and municipalities. Several political,
      administrative, financial, legal, and cultural issues were identified as critical
      factors that need to be considered when developing and implementing similar
      binational projects. The lack of understanding of public health practices,
      implementation of existing policies, legislation, and management procedures in
      Mexico and the United States may delay or cancel binational research, affecting
      the working relation of both countries. Many challenges were identified:
      multiagency/multifunding, ethical/budget clearances, project management,
      administrative procedures, laboratory procedures, cultural issues, and project
      communications. Binational projects are complex; they require coordination
      between agencies and institutions at federal, state, and local levels and between
      countries and need a political, administrative, bureaucratic, cultural, and
      language balance. Binational agencies and staff should coordinate these projects 
      for successful implementation.
FAU - de Cosio, Federico G
AU  - de Cosio FG
AD  - Pan American Health Organization, Washington, D.C., USA. decosige@paho.org
FAU - Diaz-Apodaca, Beatriz A
AU  - Diaz-Apodaca BA
FAU - Ruiz-Holguin, Rosalba
AU  - Ruiz-Holguin R
FAU - Lara, Agustin
AU  - Lara A
FAU - Castillo-Salgado, Carlos
AU  - Castillo-Salgado C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Rev Panam Salud Publica
JT  - Revista panamericana de salud publica = Pan American journal of public health
JID - 9705400
SB  - IM
MH  - Adult
MH  - Capital Financing
MH  - Centers for Disease Control and Prevention, U.S.
MH  - Child
MH  - Communication
MH  - Cross-Sectional Studies/economics/ethics/methods
MH  - Culture
MH  - Diabetes Mellitus, Type 2/blood/*epidemiology/ethnology/prevention & control
MH  - Female
MH  - Government Agencies
MH  - Government Programs/economics/ethics/*methods/organization &
      administration/statistics & numerical data
MH  - Health Surveys/economics/ethics/*methods/statistics & numerical data
MH  - Humans
MH  - Interinstitutional Relations
MH  - International Cooperation
MH  - Male
MH  - Mexico/epidemiology
MH  - Pan American Health Organization
MH  - Prevalence
MH  - Program Evaluation
MH  - Southwestern United States/epidemiology
MH  - United States
MH  - World Health Organization
EDAT- 2010/10/22 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/10/22 06:00
PHST- 2010/04/19 00:00 [received]
PHST- 2010/08/24 00:00 [accepted]
PHST- 2010/10/22 06:00 [entrez]
PHST- 2010/10/22 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - S1020-49892010000900004 [pii]
AID - 10.1590/s1020-49892010000900004 [doi]
PST - ppublish
SO  - Rev Panam Salud Publica. 2010 Sep;28(3):151-8. doi:
      10.1590/s1020-49892010000900004.


PMID- 20962797
OWN - NLM
STAT- MEDLINE
DCOM- 20101207
LR  - 20211020
IS  - 1476-4687 (Electronic)
IS  - 0028-0836 (Linking)
VI  - 467
IP  - 7318
DP  - 2010 Oct 21
TI  - A hammer blow to national ethics.
PG  - 884
LID - 10.1038/467884a [doi]
LA  - eng
PT  - Editorial
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
SB  - IM
MH  - China
MH  - *Ethics, Professional
MH  - Humans
MH  - Research Personnel/*ethics/*legislation & jurisprudence
MH  - *Scientific Misconduct
EDAT- 2010/10/22 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/10/22 06:00
PHST- 2010/10/22 06:00 [entrez]
PHST- 2010/10/22 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 467884a [pii]
AID - 10.1038/467884a [doi]
PST - ppublish
SO  - Nature. 2010 Oct 21;467(7318):884. doi: 10.1038/467884a.


PMID- 20962066
OWN - NLM
STAT- MEDLINE
DCOM- 20110429
LR  - 20151119
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 1
DP  - 2011 Jan
TI  - Deception as treatment: the case of depression.
PG  - 13-6
LID - 10.1136/jme.2010.039313 [doi]
AB  - Is it ever right to prescribe placebos to patients in clinical practice? The
      General Medical Council is ambivalent about the issue; the American Medical
      Association asserts that placebos can be administered only if the patient is
      (somehow) 'informed'. The potential problem with placebos is that they may
      involve deception: indeed, if this is the case, an ethical tension arises over
      the patient's autonomy and the physician's requirement to be open and honest, and
      the notion that medical care should be the primary concern. This paper examines
      the case of depression as an entry point for understanding the complexities of
      the prescription of placebos. Recent important meta-analyses of antidepressants
      claim that they are not significantly more effective in a clinical setting than
      placebos. Given that antidepressants have numerous adverse side effects and are
      hugely expensive, this provocative research has serious potential ethical and
      practical implications for patients and medical providers. Should placebos be
      prescribed in place of antidepressants? The case of depression highlights another
      important issue which medical ethical codes have hitherto overlooked: well-being 
      is not synonymous with being realistic about oneself, one's circumstances and the
      future. While severely depressed individuals are unduly pessimistic about
      themselves and the world around them, treatment of depressed individuals can be
      deemed successful when patients have successfully attained those positive
      illusions that are indicative of psychological health. This is exactly what
      successful psychological treatments of depression seem to achieve. It is
      therefore possible that there may be a limited unavoidable role for deception in 
      medicine.
FAU - Blease, Charlotte
AU  - Blease C
AD  - School of Politics, International Studies and Philosophy, Queen's University, 21 
      University Square, Belfast BT7 1PA, UK. c.blease@qub.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20101020
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
RN  - 0 (Antidepressive Agents)
RN  - 0 (Placebos)
SB  - IM
MH  - Antidepressive Agents/*therapeutic use
MH  - *Deception
MH  - Depressive Disorder/*drug therapy
MH  - Humans
MH  - Patient Rights/ethics/standards
MH  - *Placebo Effect
MH  - Placebos/*therapeutic use
MH  - Practice Patterns, Physicians'/*ethics/standards
MH  - Treatment Outcome
EDAT- 2010/10/22 06:00
MHDA- 2011/04/30 06:00
CRDT- 2010/10/22 06:00
PHST- 2010/10/22 06:00 [entrez]
PHST- 2010/10/22 06:00 [pubmed]
PHST- 2011/04/30 06:00 [medline]
AID - jme.2010.039313 [pii]
AID - 10.1136/jme.2010.039313 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Jan;37(1):13-6. doi: 10.1136/jme.2010.039313. Epub 2010 Oct
      20.


PMID- 20962065
OWN - NLM
STAT- MEDLINE
DCOM- 20110506
LR  - 20110124
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 2
DP  - 2011 Feb
TI  - If I were a rich man could I sell a pancreas? A study in the locus of oppression.
PG  - 109-12
LID - 10.1136/jme.2010.039636 [doi]
AB  - Dan Brock argues that since the unexploitable rich could sell their kidneys too, 
      exploitation could not be an essential feature of organ vending. This paper takes
      his claim as the point of departure for a discussion on the locus of organ
      vending-associated oppression. While it accepts Brock's conclusion, it explores
      the possibility that such oppression is invariably found rather outside the
      sphere of exchange. It then analyses the implications of this possibility for the
      discourse surrounding the ethics of organ vending.
FAU - Epstein, M
AU  - Epstein M
AD  - Barts and The London School of Medicine and Dentistry, Queen Mary University of
      London, 2 Newark Street, London E1 2AT, UK. m.epstein@qmul.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20101020
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Commerce/ethics
MH  - Female
MH  - Humans
MH  - Living Donors/*psychology
MH  - Male
MH  - Organ Transplantation/economics/*ethics/psychology
MH  - Pancreas Transplantation/economics/ethics/psychology
MH  - Socioeconomic Factors
MH  - Tissue and Organ Procurement/economics/*ethics
EDAT- 2010/10/22 06:00
MHDA- 2011/05/07 06:00
CRDT- 2010/10/22 06:00
PHST- 2010/10/22 06:00 [entrez]
PHST- 2010/10/22 06:00 [pubmed]
PHST- 2011/05/07 06:00 [medline]
AID - jme.2010.039636 [pii]
AID - 10.1136/jme.2010.039636 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Feb;37(2):109-12. doi: 10.1136/jme.2010.039636. Epub 2010 Oct 
      20.


PMID- 20962064
OWN - NLM
STAT- MEDLINE
DCOM- 20110315
LR  - 20161125
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 12
DP  - 2010 Dec
TI  - Case-based seminars in medical ethics education: how medical students define and 
      discuss moral problems.
PG  - 816-20
LID - 10.1136/jme.2010.036574 [doi]
AB  - Discussion of real cases encountered by medical students has been advocated as a 
      component of medical ethics education. Suggested benefits include: a focus on the
      actual problems that medical students confront; active learner involvement; and
      facilitation of an exploration of the meaning of their own values in relation to 
      professional behaviour. However, the approach may also carry risks: students may 
      focus too narrowly on particular clinical topics or show a preference for
      discussing legal problems that may appear to have clearer solutions. Teaching may
      therefore omit areas generally considered to be important components of the
      curriculum. In this paper, the authors present an analysis of the moral problems 
      raised by medical students in response to a request to describe ethically
      problematic cases they had encountered during two clinical attachments, for the
      purpose of educational discussion at case-based seminars. We discuss the problems
      raised and compare the content of the cases to the UK Consensus Statement on core
      content of learning. The authors also describe the approaches that the students
      used to undertake an initial analysis of the problems raised, and consider
      possible implications for the development of medical ethics education.
FAU - Donaldson, Thomas M
AU  - Donaldson TM
AD  - General Practice Education Group, Institute of Public Health, University of
      Cambridge, Forvie Site, Robinson Way, Cambridge, CB2 0SR, UK.
      tmd28@doctors.org.uk
FAU - Fistein, Elizabeth
AU  - Fistein E
FAU - Dunn, Michael
AU  - Dunn M
LA  - eng
PT  - Journal Article
DEP - 20101020
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Education, Medical, Undergraduate/*methods
MH  - Ethics, Medical/*education
MH  - Humans
MH  - *Morals
MH  - *Problem-Based Learning
MH  - Students, Medical/psychology
MH  - Teaching/*methods
MH  - United Kingdom
EDAT- 2010/10/22 06:00
MHDA- 2011/03/16 06:00
CRDT- 2010/10/22 06:00
PHST- 2010/10/22 06:00 [entrez]
PHST- 2010/10/22 06:00 [pubmed]
PHST- 2011/03/16 06:00 [medline]
AID - jme.2010.036574 [pii]
AID - 10.1136/jme.2010.036574 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Dec;36(12):816-20. doi: 10.1136/jme.2010.036574. Epub 2010 Oct
      20.


PMID- 20960961
OWN - NLM
STAT- MEDLINE
DCOM- 20101025
LR  - 20101020
IS  - 0023-7205 (Print)
IS  - 0023-7205 (Linking)
VI  - 107
IP  - 34
DP  - 2010 Aug 25-31
TI  - [Ethics and transportation certificates 1: issuing certificates sets high demands
      on the physician's integrity and objectivity].
PG  - 1941; discussion 1941-2
FAU - Flodin, Thomas
AU  - Flodin T
LA  - swe
PT  - Comment
PT  - Journal Article
TT  - Etik och transportintyg 1: Utfardande av intyg staller hoga krav pa lakarens
      integritet och objektivitet.
PL  - Sweden
TA  - Lakartidningen
JT  - Lakartidningen
JID - 0027707
SB  - IM
CON - Lakartidningen. 2010 Aug 11-24;107(32-33):1856-7. PMID: 20873335
MH  - *Ethics, Medical
MH  - Humans
MH  - Physician's Role
MH  - Sweden
MH  - Transportation of Patients/*ethics
EDAT- 2010/10/22 06:00
MHDA- 2010/10/26 06:00
CRDT- 2010/10/22 06:00
PHST- 2010/10/22 06:00 [entrez]
PHST- 2010/10/22 06:00 [pubmed]
PHST- 2010/10/26 06:00 [medline]
PST - ppublish
SO  - Lakartidningen. 2010 Aug 25-31;107(34):1941; discussion 1941-2.


PMID- 20960737
OWN - NLM
STAT- MEDLINE
DCOM- 20110104
LR  - 20101020
IS  - 0945-1129 (Print)
IS  - 0945-1129 (Linking)
VI  - 63
IP  - 10
DP  - 2010 Oct
TI  - [Dealing with ethically complex topics in training - preimplantation diagnosis:
      communicating not only abstract but also emotional aspects].
PG  - 626-9
FAU - Schonfelder, Katja
AU  - Schonfelder K
AD  - katja.schoenfelder@gmx.de
LA  - ger
PT  - Journal Article
TT  - Ethisch komplexe Themen im Unterricht behandeln--Beispiel PID: Schuler nicht nur 
      abstrakt, sondern auch emotional ansprechen.
PL  - Germany
TA  - Pflege Z
JT  - Pflege Zeitschrift
JID - 9430463
MH  - *Communication
MH  - Curriculum
MH  - *Education, Nursing
MH  - *Emotions
MH  - Ethics, Nursing/*education
MH  - Female
MH  - Germany
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - Nurse-Patient Relations/*ethics
MH  - Pregnancy
MH  - Preimplantation Diagnosis/*ethics/*nursing/psychology
EDAT- 2010/10/22 06:00
MHDA- 2011/01/05 06:00
CRDT- 2010/10/22 06:00
PHST- 2010/10/22 06:00 [entrez]
PHST- 2010/10/22 06:00 [pubmed]
PHST- 2011/01/05 06:00 [medline]
PST - ppublish
SO  - Pflege Z. 2010 Oct;63(10):626-9.


PMID- 20960727
OWN - NLM
STAT- MEDLINE
DCOM- 20110104
LR  - 20101020
IS  - 0945-1129 (Print)
IS  - 0945-1129 (Linking)
VI  - 63
IP  - 10
DP  - 2010 Oct
TI  - [Incontinence taboo - an ethical observation: structural problems delegated to
      nurses].
PG  - 590-2
FAU - Hofmann, Irmgard
AU  - Hofmann I
AD  - info@irmgard-hofmann.de
LA  - ger
PT  - Journal Article
TT  - Tabu Inkontinenz--eine ethische Betrachtung: Strukturprobleme auf Pflegende
      abgewalzt.
PL  - Germany
TA  - Pflege Z
JT  - Pflege Zeitschrift
JID - 9430463
MH  - *Ethics, Nursing
MH  - Fecal Incontinence/*nursing/psychology
MH  - Female
MH  - Germany
MH  - Humans
MH  - Male
MH  - Nurse-Patient Relations/ethics
MH  - *Personhood
MH  - *Shame
MH  - Social Values
MH  - Taboo/*psychology
MH  - Urinary Incontinence/*nursing/psychology
EDAT- 2010/10/22 06:00
MHDA- 2011/01/05 06:00
CRDT- 2010/10/22 06:00
PHST- 2010/10/22 06:00 [entrez]
PHST- 2010/10/22 06:00 [pubmed]
PHST- 2011/01/05 06:00 [medline]
PST - ppublish
SO  - Pflege Z. 2010 Oct;63(10):590-2.


PMID- 20956219
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20220410
IS  - 1524-4539 (Electronic)
IS  - 0009-7322 (Linking)
VI  - 122
IP  - 18 Suppl 3
DP  - 2010 Nov 2
TI  - Part 3: ethics: 2010 American Heart Association Guidelines for Cardiopulmonary
      Resuscitation and Emergency Cardiovascular Care.
PG  - S665-75
LID - 10.1161/CIRCULATIONAHA.110.970905 [doi]
FAU - Morrison, Laurie J
AU  - Morrison LJ
FAU - Kierzek, Gerald
AU  - Kierzek G
FAU - Diekema, Douglas S
AU  - Diekema DS
FAU - Sayre, Michael R
AU  - Sayre MR
FAU - Silvers, Scott M
AU  - Silvers SM
FAU - Idris, Ahamed H
AU  - Idris AH
FAU - Mancini, Mary E
AU  - Mancini ME
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Circulation
JT  - Circulation
JID - 0147763
SB  - IM
MH  - *American Heart Association
MH  - Cardiology/*ethics/standards
MH  - Cardiopulmonary Resuscitation/*ethics/standards
MH  - Emergency Medical Services/ethics/standards
MH  - Humans
MH  - *Practice Guidelines as Topic/standards
MH  - Resuscitation Orders/ethics
MH  - United States
EDAT- 2010/10/22 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/10/20 06:00
PHST- 2010/10/20 06:00 [entrez]
PHST- 2010/10/22 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - 122/18_suppl_3/S665 [pii]
AID - 10.1161/CIRCULATIONAHA.110.970905 [doi]
PST - ppublish
SO  - Circulation. 2010 Nov 2;122(18 Suppl 3):S665-75. doi:
      10.1161/CIRCULATIONAHA.110.970905.


PMID- 20937485
OWN - NLM
STAT- MEDLINE
DCOM- 20110223
LR  - 20210403
IS  - 1532-0480 (Electronic)
IS  - 1532-0464 (Linking)
VI  - 43
IP  - 5 Suppl
DP  - 2010 Oct
TI  - Ethical, legal and social issues for personal health records and applications.
PG  - S51-S55
LID - S1532-0464(10)00061-4 [pii]
LID - 10.1016/j.jbi.2010.05.003 [doi]
AB  - Robert Wood Johnson Foundation's Project HealthDesign included funding of an
      ethical, legal and social issues (ELSI) team, to serve in an advisory capacity to
      the nine design projects. In that capacity, the authors had the opportunity to
      analyze the personal health record (PHR) and personal health application (PHA)
      implementations for recurring themes. PHRs and PHAs invert the long-standing
      paradigm of health care institutions as the authoritative data-holders and
      data-processors in the system. With PHRs and PHAs, the individual is the center
      of his or her own health data universe, a position that brings new benefits but
      also entails new responsibilities for patients and other parties in the health
      information infrastructure. Implications for law, policy and practice follow from
      this shift. This article summarizes the issues raised by the first phase of
      Project HealthDesign projects, categorizing them into four topics: privacy and
      confidentiality, data security, decision support, and HIPAA and related
      legal-regulatory requirements. Discussion and resolution of these issues will be 
      critical to successful PHR/PHA implementations in the years to come.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Cushman, Reid
AU  - Cushman R
AD  - University of Miami Health System, School of Medicine, Department of Medical
      Information Technology, 1051 N.W. 14th Street, Miami, FL 33136, United States.
      Electronic address: rcushman@med.miami.edu.
FAU - Froomkin, A Michael
AU  - Froomkin AM
AD  - University of Miami School of Law, P.O. Box 248087, Coral Gables, FL 33124,
      United States.
FAU - Cava, Anita
AU  - Cava A
AD  - University of Miami School of Business Administration, Jenkins Building 323-F,
      P.O. Box 248022, Coral Gables, FL 33124, United States.
FAU - Abril, Patricia
AU  - Abril P
AD  - University of Miami School of Business Administration, Jenkins Building 323-F,
      P.O. Box 248022, Coral Gables, FL 33124, United States.
FAU - Goodman, Kenneth W
AU  - Goodman KW
AD  - University of Miami Ethics Programs, Dominion Tower, 1400 N.W. 10th Ave., Suite
      916 (M-825), Miami, FL 33136, United States.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Biomed Inform
JT  - Journal of biomedical informatics
JID - 100970413
SB  - IM
MH  - *Computer Security
MH  - *Confidentiality
MH  - Database Management Systems/*ethics/*legislation & jurisprudence
MH  - Decision Support Systems, Clinical
MH  - Health Insurance Portability and Accountability Act
MH  - *Health Records, Personal
MH  - Humans
MH  - United States
EDAT- 2010/10/22 06:00
MHDA- 2011/02/24 06:00
CRDT- 2010/10/13 06:00
PHST- 2010/02/11 00:00 [received]
PHST- 2010/04/15 00:00 [revised]
PHST- 2010/05/09 00:00 [accepted]
PHST- 2010/10/13 06:00 [entrez]
PHST- 2010/10/22 06:00 [pubmed]
PHST- 2011/02/24 06:00 [medline]
AID - S1532-0464(10)00061-4 [pii]
AID - 10.1016/j.jbi.2010.05.003 [doi]
PST - ppublish
SO  - J Biomed Inform. 2010 Oct;43(5 Suppl):S51-S55. doi: 10.1016/j.jbi.2010.05.003.


PMID- 20937482
OWN - NLM
STAT- MEDLINE
DCOM- 20110223
LR  - 20220311
IS  - 1532-0480 (Electronic)
IS  - 1532-0464 (Linking)
VI  - 43
IP  - 5 Suppl
DP  - 2010 Oct
TI  - Project HealthDesign: rethinking the power and potential of personal health
      records.
PG  - S3-S5
LID - S1532-0464(10)00133-4 [pii]
LID - 10.1016/j.jbi.2010.09.001 [doi]
AB  - Project HealthDesign, a multi-year, multi-site project sponsored by the Robert
      Wood Johnson Foundation with additional support from the California HealthCare
      Foundation, is designed to stimulate innovation in personal health records
      (PHRs). Project HealthDesign teams employed user-centered design processes to
      create designs and prototypes of computer-based applications to support and
      enhance human health for a wide range of patients, from children with chronic
      health conditions to elders transitioning from hospital to home. A program design
      philosophy encouraged designers to envision PHRs as a suite of personal health
      information management tools, or applications, separate from, but drawing upon,
      personal health data from a variety of sources. In addition to information
      contained in one's medical record, these personal health data included
      patient-supplied clinical parameters such as blood glucose and daily weights; as 
      well as patient-generated observations of daily living (ODLs) - the unique,
      idiosyncratic cues, such as sleep adequacy or confidence in self care, that
      inform patients about their abilities to manage health challenges and take
      healthy action. A common technical platform provided infrastructure services such
      as data standards and identity-management protocols, and helped to demonstrate a 
      scalable, efficient approach to user-centered design of personal health
      information management systems. The program's ethical, legal and social issues
      consultancy identified challenges to acceleration of action-focused PHRs:
      personal control of privacy choices, management of privacy in home conditions,
      and rebalancing power structures in shared decision making.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Brennan, Patricia Flatley
AU  - Brennan PF
AD  - School of Nursing, University of Wisconsin-Madison, H6/241 CSC, 600 Highland
      Avenue, Madison, WI 53792, USA. Electronic address: pbrennan@engr.wisc.edu.
FAU - Downs, Stephen
AU  - Downs S
AD  - Robert Wood Johnson Foundation, Princeton, NJ, USA.
FAU - Casper, Gail
AU  - Casper G
AD  - School of Nursing, University of Wisconsin-Madison, H6/241 CSC, 600 Highland
      Avenue, Madison, WI 53792, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Biomed Inform
JT  - Journal of biomedical informatics
JID - 100970413
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Child
MH  - Database Management Systems
MH  - Diffusion of Innovation
MH  - *Health Records, Personal
MH  - Humans
MH  - *Medical Informatics
MH  - *Medical Records Systems, Computerized
MH  - Middle Aged
EDAT- 2010/10/22 06:00
MHDA- 2011/02/24 06:00
CRDT- 2010/10/13 06:00
PHST- 2010/07/30 00:00 [received]
PHST- 2010/09/03 00:00 [revised]
PHST- 2010/09/03 00:00 [accepted]
PHST- 2010/10/13 06:00 [entrez]
PHST- 2010/10/22 06:00 [pubmed]
PHST- 2011/02/24 06:00 [medline]
AID - S1532-0464(10)00133-4 [pii]
AID - 10.1016/j.jbi.2010.09.001 [doi]
PST - ppublish
SO  - J Biomed Inform. 2010 Oct;43(5 Suppl):S3-S5. doi: 10.1016/j.jbi.2010.09.001.


PMID- 27707348
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1351-5578 (Print)
IS  - 1351-5578 (Linking)
VI  - 18
IP  - 1
DP  - 2010 Oct 22
TI  - Ethical decision making in social research: a practical guide (2009) Ron Iphofen 
      Ethical decision making in social research: a practical guide (2009) Palgrave
      Macmillan 240 pound52 9780230210356 023021035X [Formula: see text].
PG  - 90
AB  - The author of this book describes it as a guide to thinking through the problems 
      of conducting ethical research in the social sciences. As such it is intended to 
      be of practical help to social researchers in resolving ethical issues that arise
      from undertaking research involving human subjects. Although it is written with
      social scientists in mind, much of the content is relevant to nurses undertaking 
      research within the health service.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurse Res
JT  - Nurse researcher
JID - 9435953
EDAT- 2010/10/22 00:00
MHDA- 2010/10/22 00:01
CRDT- 2016/10/07 06:00
PHST- 2016/10/07 06:00 [entrez]
PHST- 2010/10/22 00:00 [pubmed]
PHST- 2010/10/22 00:01 [medline]
AID - 10.7748/nr.18.1.90.s4 [doi]
PST - ppublish
SO  - Nurse Res. 2010 Oct 22;18(1):90. doi: 10.7748/nr.18.1.90.s4.


PMID- 20960580
OWN - NLM
STAT- MEDLINE
DCOM- 20110928
LR  - 20110615
IS  - 1099-1492 (Electronic)
IS  - 0952-3480 (Linking)
VI  - 24
IP  - 5
DP  - 2011 Jun
TI  - Quantitative magnetisation transfer imaging in glioma: preliminary results.
PG  - 492-8
LID - 10.1002/nbm.1614 [doi]
AB  - Quantitative magnetisation transfer imaging (qMTI) is an extension of
      conventional MT techniques and allows the measurement of parameters that reflect 
      tissue ultrastructure through the properties of macromolecule-bound protons;
      these include the bound proton fraction and the relaxation times of free and
      bound proton pools. It has been used in multiple sclerosis and Alzheimer's
      disease, and has shown changes in some of the parameters, particularly the bound 
      proton fraction. The purpose of this pilot study was to assess whether qMTI could
      distinguish between gliomas and normal brain tissue, and provide proof of
      principle for its use in tumour characterisation. Eight subjects [three men, five
      women; mean age, 44 years; range, 27-66 years; seven World Health Organization
      (WHO) Grade II, one Grade III] with biopsy-proven glioma were imaged with a
      structural MRI protocol that included three-dimensional qMTI. qMTI parameters
      were extracted from regions of interest selected from different tumour components
      visible on conventional MR sequences, normal-appearing peritumoral tissue and
      distant normal-appearing white matter. All patients gave informed consent and the
      study was approved by the Local Research Ethics Committee. Almost all of the qMTI
      parameters detected abnormalities in both glioma and the peritumoral region
      relative to the distant white matter. In particular, the bound proton fraction
      was reduced significantly from 6.0 percentage units (pu) [standard deviation
      (SD), 0.5 pu] in normal-appearing white matter to 1.7 pu (SD = 0.5 pu) in solid
      tumour and 2.2 pu (SD = 0.5 pu) in peritumoral areas. This work shows that qMTI
      reveals abnormalities, not only in glioma, but also in the apparently normal
      tissue surrounding the conventionally defined tumour. Thus, qMTI shows promise
      for tumour characterisation and for studying tumour boundaries. These preliminary
      data justify larger studies in a range of different tumour types and grades.
CI  - Copyright (c) 2010 John Wiley & Sons, Ltd.
FAU - Tozer, Daniel J
AU  - Tozer DJ
AD  - UCL Institute of Neurology, London, UK. d.tozer@ion.ucl.ac.uk
FAU - Rees, Jeremy H
AU  - Rees JH
FAU - Benton, Christopher E
AU  - Benton CE
FAU - Waldman, Adam D
AU  - Waldman AD
FAU - Jager, H Rolf
AU  - Jager HR
FAU - Tofts, Paul S
AU  - Tofts PS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101019
PL  - England
TA  - NMR Biomed
JT  - NMR in biomedicine
JID - 8915233
SB  - IM
MH  - Adult
MH  - Aged
MH  - Diagnostic Imaging/*methods
MH  - Female
MH  - Glioma/*pathology
MH  - Humans
MH  - Magnetics/*methods
MH  - Male
MH  - Middle Aged
EDAT- 2010/10/21 06:00
MHDA- 2011/09/29 06:00
CRDT- 2010/10/21 06:00
PHST- 2010/01/15 00:00 [received]
PHST- 2010/07/30 00:00 [revised]
PHST- 2010/08/02 00:00 [accepted]
PHST- 2010/10/21 06:00 [entrez]
PHST- 2010/10/21 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 10.1002/nbm.1614 [doi]
PST - ppublish
SO  - NMR Biomed. 2011 Jun;24(5):492-8. doi: 10.1002/nbm.1614. Epub 2010 Oct 19.


PMID- 20960468
OWN - NLM
STAT- MEDLINE
DCOM- 20110302
LR  - 20211020
IS  - 1098-1004 (Electronic)
IS  - 1059-7794 (Linking)
VI  - 31
IP  - 12
DP  - 2010 Dec
TI  - How to catch all those mutations--the report of the third Human Variome Project
      Meeting, UNESCO Paris, May 2010.
PG  - 1374-81
LID - 10.1002/humu.21379 [doi]
AB  - The third Human Variome Project (HVP) Meeting "Integration and Implementation"
      was held under UNESCO Patronage in Paris, France, at the UNESCO Headquarters May 
      10-14, 2010. The major aims of the HVP are the collection, curation, and
      distribution of all human genetic variation affecting health. The HVP has drawn
      together disparate groups, by country, gene of interest, and expertise, who are
      working for the common good with the shared goal of pushing the boundaries of the
      human variome and collaborating to avoid unnecessary duplication. The meeting
      addressed the 12 key areas that form the current framework of HVP activities:
      Ethics; Nomenclature and Standards; Publication, Credit and Incentives; Data
      Collection from Clinics; Overall Data Integration and Access-Peripheral
      Systems/Software; Data Collection from Laboratories; Assessment of Pathogenicity;
      Country Specific Collection; Translation to Healthcare and Personalized Medicine;
      Data Transfer, Databasing, and Curation; Overall Data Integration and
      Access-Central Systems; and Funding Mechanisms and Sustainability. In addition,
      three societies that support the goals and the mission of HVP also held their own
      Workshops with the view to advance disease-specific variation data collection and
      utilization: the International Society for Gastrointestinal Hereditary Tumours,
      the Micronutrient Genomics Project, and the Neurogenetics Consortium.
CI  - (c) 2010 Wiley-Liss, Inc.
FAU - Kohonen-Corish, Maija R J
AU  - Kohonen-Corish MR
AD  - Cancer Research Program, Garvan Institute of Medical Research, St. Vincent's
      Clinical School, University of NSW, Sydney, NSW, Australia.
      m.corish@garvan.org.au
FAU - Al-Aama, Jumana Y
AU  - Al-Aama JY
FAU - Auerbach, Arleen D
AU  - Auerbach AD
FAU - Axton, Myles
AU  - Axton M
FAU - Barash, Carol Isaacson
AU  - Barash CI
FAU - Bernstein, Inge
AU  - Bernstein I
FAU - Beroud, Christophe
AU  - Beroud C
FAU - Burn, John
AU  - Burn J
FAU - Cunningham, Fiona
AU  - Cunningham F
FAU - Cutting, Garry R
AU  - Cutting GR
FAU - den Dunnen, Johan T
AU  - den Dunnen JT
FAU - Greenblatt, Marc S
AU  - Greenblatt MS
FAU - Kaput, Jim
AU  - Kaput J
FAU - Katz, Michael
AU  - Katz M
FAU - Lindblom, Annika
AU  - Lindblom A
FAU - Macrae, Finlay
AU  - Macrae F
FAU - Maglott, Donna
AU  - Maglott D
FAU - Moslein, Gabriela
AU  - Moslein G
FAU - Povey, Sue
AU  - Povey S
FAU - Ramesar, Raj
AU  - Ramesar R
FAU - Richards, Sue
AU  - Richards S
FAU - Seminara, Daniela
AU  - Seminara D
FAU - Sobrido, Maria-Jesus
AU  - Sobrido MJ
FAU - Tavtigian, Sean
AU  - Tavtigian S
FAU - Taylor, Graham
AU  - Taylor G
FAU - Vihinen, Mauno
AU  - Vihinen M
FAU - Winship, Ingrid
AU  - Winship I
FAU - Cotton, Richard G H
AU  - Cotton RG
CN  - Human Variome Project Meeting
LA  - eng
GR  - R37 DK044003/DK/NIDDK NIH HHS/United States
GR  - R37 DK044003-21/DK/NIDDK NIH HHS/United States
PT  - Congress
PL  - United States
TA  - Hum Mutat
JT  - Human mutation
JID - 9215429
SB  - IM
MH  - Data Collection
MH  - Databases, Genetic/economics
MH  - Genetic Variation/*genetics
MH  - Genome, Human/*genetics
MH  - Humans
MH  - Motivation
MH  - Mutation/ethics/*genetics
MH  - Paris
MH  - Precision Medicine
MH  - Software
MH  - Terminology as Topic
MH  - United Nations
PMC - PMC3119486
MID - NIHMS277169
EDAT- 2010/10/21 06:00
MHDA- 2011/03/03 06:00
CRDT- 2010/10/21 06:00
PHST- 2010/10/21 06:00 [entrez]
PHST- 2010/10/21 06:00 [pubmed]
PHST- 2011/03/03 06:00 [medline]
AID - 10.1002/humu.21379 [doi]
PST - ppublish
SO  - Hum Mutat. 2010 Dec;31(12):1374-81. doi: 10.1002/humu.21379.


PMID- 20960004
OWN - NLM
STAT- MEDLINE
DCOM- 20110225
LR  - 20181201
IS  - 1433-8491 (Electronic)
IS  - 0940-1334 (Linking)
VI  - 260 Suppl 2
DP  - 2010 Nov
TI  - Ethics in psychiatry: the lessons we learn from Nazi psychiatry.
PG  - S152-6
LID - 10.1007/s00406-010-0158-2 [doi]
AB  - Under the Euthanasia Program of Nazi Germany, more than 200,000 psychiatric
      patients were killed by doctors in psychiatric institutions. After summarising
      the historical facts and the slow and still going-on process of illuminating and 
      understanding what happened, some ethical consequences are drawn. What can we
      learn from history? The following aspects are addressed: the special situation of
      psychiatry in times of war, bioethics and biopolitics, the responsibility of the 
      psychiatrist for the individual patient, the effects of hierarchy on personal
      conscience and responsibility, the unethical "curable-uncurable" distinction and 
      the atrocious concept that persons differ in their value.
FAU - von Cranach, Michael
AU  - von Cranach M
AD  - m.v.cranach@t-online.de
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Portrait
PT  - Review
DEP - 20101020
PL  - Germany
TA  - Eur Arch Psychiatry Clin Neurosci
JT  - European archives of psychiatry and clinical neuroscience
JID - 9103030
SB  - IM
MH  - Ethics, Medical/*history
MH  - History, 20th Century
MH  - Humans
MH  - National Socialism/*history
MH  - Psychiatry/*ethics/*history
EDAT- 2010/10/21 06:00
MHDA- 2011/02/26 06:00
CRDT- 2010/10/21 06:00
PHST- 2010/06/14 00:00 [received]
PHST- 2010/08/07 00:00 [accepted]
PHST- 2010/10/21 06:00 [entrez]
PHST- 2010/10/21 06:00 [pubmed]
PHST- 2011/02/26 06:00 [medline]
AID - 10.1007/s00406-010-0158-2 [doi]
PST - ppublish
SO  - Eur Arch Psychiatry Clin Neurosci. 2010 Nov;260 Suppl 2:S152-6. doi:
      10.1007/s00406-010-0158-2. Epub 2010 Oct 20.


PMID- 20959893
OWN - NLM
STAT- MEDLINE
DCOM- 20110404
LR  - 20211020
IS  - 1866-0452 (Electronic)
IS  - 1866-0452 (Linking)
VI  - 107
IP  - 37
DP  - 2010 Sep
TI  - Re: Deep brain stimulation for psychiatric disorders. Topic for ethics committee.
PG  - 644; author reply 645-6
LID - 10.3238/arztebl.2010.0644b [doi]
FAU - Meyer, Frank P
AU  - Meyer FP
LA  - eng
PT  - Comment
PT  - Letter
DEP - 20100917
PL  - Germany
TA  - Dtsch Arztebl Int
JT  - Deutsches Arzteblatt international
JID - 101475967
SB  - IM
CON - Dtsch Arztebl Int. 2010 Feb;107(7):105-13. PMID: 20221269
MH  - Deep Brain Stimulation/*ethics
MH  - Epilepsy/therapy
MH  - Ethics Committees
MH  - *Ethics, Medical
MH  - Germany
MH  - Humans
MH  - Informed Consent/ethics
MH  - Mental Disorders/*therapy
MH  - Obsessive-Compulsive Disorder/therapy
MH  - Pain Management
MH  - Parkinson Disease/therapy
PMC - PMC2956200
EDAT- 2010/10/21 06:00
MHDA- 2011/04/05 06:00
CRDT- 2010/10/21 06:00
PHST- 2010/10/21 06:00 [entrez]
PHST- 2010/10/21 06:00 [pubmed]
PHST- 2011/04/05 06:00 [medline]
AID - 10.3238/arztebl.2010.0644b [doi]
PST - ppublish
SO  - Dtsch Arztebl Int. 2010 Sep;107(37):644; author reply 645-6. doi:
      10.3238/arztebl.2010.0644b. Epub 2010 Sep 17.


PMID- 20959878
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20220331
IS  - 1654-9880 (Electronic)
IS  - 1654-9880 (Linking)
VI  - 3
DP  - 2010 Sep 27
TI  - Ageing and adult health status in eight lower-income countries: the INDEPTH
      WHO-SAGE collaboration.
LID - 10.3402/gha.v3i0.5302 [doi]
AB  - BACKGROUND: Globally, ageing impacts all countries, with a majority of older
      persons residing in lower- and middle-income countries now and into the future.
      An understanding of the health and well-being of these ageing populations is
      important for policy and planning; however, research on ageing and adult health
      that informs policy predominantly comes from higher-income countries. A
      collaboration between the WHO Study on global AGEing and adult health (SAGE) and 
      International Network for the Demographic Evaluation of Populations and Their
      Health in developing countries (INDEPTH), with support from the US National
      Institute on Aging (NIA) and the Swedish Council for Working Life and Social
      Research (FAS), has resulted in valuable health, disability and well-being
      information through a first wave of data collection in 2006-2007 from field sites
      in South Africa, Tanzania, Kenya, Ghana, Viet Nam, Bangladesh, Indonesia and
      India. OBJECTIVE: To provide an overview of the demographic and health
      characteristics of participating countries, describe the research collaboration
      and introduce the first dataset and outputs. METHODS: Data from two SAGE survey
      modules implemented in eight Health and Demographic Surveillance Systems (HDSS)
      were merged with core HDSS data to produce a summary dataset for the
      site-specific and cross-site analyses described in this supplement. Each
      participating HDSS site used standardised training materials and survey
      instruments. Face-to-face interviews were conducted. Ethical clearance was
      obtained from WHO and the local ethical authority for each participating HDSS
      site. RESULTS: People aged 50 years and over in the eight participating countries
      represent over 15% of the current global older population, and is projected to
      reach 23% by 2030. The Asian HDSS sites have a larger proportion of burden of
      disease from non-communicable diseases and injuries relative to their African
      counterparts. A pooled sample of over 46,000 persons aged 50 and over from these 
      eight HDSS sites was produced. The SAGE modules resulted in self-reported health,
      health status, functioning (from the WHO Disability Assessment Scale (WHODAS-II))
      and well-being (from the WHO Quality of Life instrument (WHOQoL) variables). The 
      HDSS databases contributed age, sex, marital status, education, socio-economic
      status and household size variables. CONCLUSION: The INDEPTH WHO-SAGE
      collaboration demonstrates the value and future possibilities for this type of
      research in informing policy and planning for a number of countries. This INDEPTH
      WHO-SAGE dataset will be placed in the public domain together with this
      open-access supplement and will be available through the GHA website
      (www.globalhealthaction.net) and other repositories. An improved dataset is being
      developed containing supplementary HDSS variables and vignette-adjusted health
      variables. This living collaboration is now preparing for a next wave of data
      collection.
FAU - Kowal, Paul
AU  - Kowal P
AD  - Multi-Country Studies Unit, World Health Organization, Geneva, Switzerland.
FAU - Kahn, Kathleen
AU  - Kahn K
FAU - Ng, Nawi
AU  - Ng N
FAU - Naidoo, Nirmala
AU  - Naidoo N
FAU - Abdullah, Salim
AU  - Abdullah S
FAU - Bawah, Ayaga
AU  - Bawah A
FAU - Binka, Fred
AU  - Binka F
FAU - Chuc, Nguyen T K
AU  - Chuc NT
FAU - Debpuur, Cornelius
AU  - Debpuur C
FAU - Ezeh, Alex
AU  - Ezeh A
FAU - Xavier Gomez-Olive, F
AU  - Xavier Gomez-Olive F
FAU - Hakimi, Mohammad
AU  - Hakimi M
FAU - Hirve, Siddhivinayak
AU  - Hirve S
FAU - Hodgson, Abraham
AU  - Hodgson A
FAU - Juvekar, Sanjay
AU  - Juvekar S
FAU - Kyobutungi, Catherine
AU  - Kyobutungi C
FAU - Menken, Jane
AU  - Menken J
FAU - Van Minh, Hoang
AU  - Van Minh H
FAU - Mwanyangala, Mathew A
AU  - Mwanyangala MA
FAU - Razzaque, Abdur
AU  - Razzaque A
FAU - Sankoh, Osman
AU  - Sankoh O
FAU - Kim Streatfield, P
AU  - Kim Streatfield P
FAU - Wall, Stig
AU  - Wall S
FAU - Wilopo, Siswanto
AU  - Wilopo S
FAU - Byass, Peter
AU  - Byass P
FAU - Chatterji, Somnath
AU  - Chatterji S
FAU - Tollman, Stephen M
AU  - Tollman SM
LA  - eng
PT  - Journal Article
DEP - 20100927
PL  - United States
TA  - Glob Health Action
JT  - Global health action
JID - 101496665
PMC - PMC2957285
OTO - NOTNLM
OT  - INDEPTH WHO-SAGE
OT  - ageing
OT  - burden of disease
OT  - demographic transition
OT  - disability
OT  - health status
OT  - public health
OT  - survey methods
OT  - well-being
EDAT- 2010/10/21 06:00
MHDA- 2010/10/21 06:01
CRDT- 2010/10/21 06:00
PHST- 2010/05/18 00:00 [received]
PHST- 2010/07/06 00:00 [revised]
PHST- 2010/07/08 00:00 [accepted]
PHST- 2010/10/21 06:00 [entrez]
PHST- 2010/10/21 06:00 [pubmed]
PHST- 2010/10/21 06:01 [medline]
AID - 10.3402/gha.v3i0.5302 [doi]
PST - epublish
SO  - Glob Health Action. 2010 Sep 27;3. doi: 10.3402/gha.v3i0.5302.


PMID- 20959841
OWN - NLM
STAT- MEDLINE
DCOM- 20101108
LR  - 20131121
IS  - 1532-6535 (Electronic)
IS  - 0009-9236 (Linking)
VI  - 88
IP  - 5
DP  - 2010 Nov
TI  - Clinical trials of drugs and vaccines among the desperately poor in poor nations:
      ethical challenges and ethical solutions.
PG  - 583-4
LID - 10.1038/clpt.2010.208 [doi]
AB  - Clinical research has been expanding into poor nations in recent years. In doing 
      research in such settings, the response to challenges arising due to the
      vulnerability and resultant potential exploitation of very poor subject
      populations is heightened awareness of the need for adequate local oversight and 
      regulation. More regulation, however, often is difficult to implement and may not
      be practical. The provision of benefit at the conclusion of clinical trials in
      poor nations or for poor people is a better response to the moral challenge of
      exploitation.
FAU - Caplan, A L
AU  - Caplan AL
AD  - Center for Bioethics, University of Pennsylvania, Philadelphia, Pennsylvania,
      USA. caplan@mail.med.upenn.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Pharmacol Ther
JT  - Clinical pharmacology and therapeutics
JID - 0372741
RN  - 0 (Vaccines)
SB  - IM
MH  - Clinical Trials as Topic/economics/*ethics/legislation & jurisprudence
MH  - Comprehension
MH  - *Developing Countries/economics
MH  - Drug-Related Side Effects and Adverse Reactions
MH  - Government Regulation
MH  - Humans
MH  - Informed Consent
MH  - *Moral Obligations
MH  - Patient Selection/*ethics
MH  - *Poverty Areas
MH  - Risk Assessment
MH  - *Vaccines/adverse effects
MH  - *Vulnerable Populations
EDAT- 2010/10/21 06:00
MHDA- 2010/11/09 06:00
CRDT- 2010/10/21 06:00
PHST- 2010/10/21 06:00 [entrez]
PHST- 2010/10/21 06:00 [pubmed]
PHST- 2010/11/09 06:00 [medline]
AID - clpt2010208 [pii]
AID - 10.1038/clpt.2010.208 [doi]
PST - ppublish
SO  - Clin Pharmacol Ther. 2010 Nov;88(5):583-4. doi: 10.1038/clpt.2010.208.


PMID- 20959703
OWN - NLM
STAT- MEDLINE
DCOM- 20110120
LR  - 20101020
IS  - 0091-3847 (Print)
IS  - 0091-3847 (Linking)
VI  - 38
IP  - 3
DP  - 2010 Oct
TI  - Anabolic steroid use in adolescents: identification of those at risk and
      strategies for prevention.
PG  - 105-13
LID - 10.3810/psm.2010.10.1815 [doi]
AB  - Success in sports is often defined by winning, which drives athletes to use
      performance-enhancing drugs (PEDs) to gain an advantage over opponents. Over the 
      past 20 years, use of PEDs by Olympic and professional athletes has led to public
      discussion regarding potential negative health effects and ethical implications
      of their use. Unfortunately, PEDs are not isolated to professional athletes, as
      PED use in adolescents has increased dramatically. Many professional
      organizations, including the American Academy of Orthopaedic Surgeons (AAOS),
      have taken a stance against PED use in sports. The AAOS believes neither anabolic
      steroids nor their precursors should be used to enhance performance or
      appearance, and that these substances should be banned in all sports programs.
      Pediatricians and orthopedists are often the first physicians to see these young 
      athletes. It is critical for these physicians to recognize the significance of
      the problem, have the knowledge to inform adolescents, dissuade them from future 
      use, and provide viable alternatives for meeting performance goals.
FAU - Mulcahey, Mary K
AU  - Mulcahey MK
AD  - The Warren Alpert Medical School, Brown University, Rhode Island Hospital,
      Providence, RI, USA. mary_mulcahey@brown.edu
FAU - Schiller, Jonathan R
AU  - Schiller JR
FAU - Hulstyn, Michael J
AU  - Hulstyn MJ
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Phys Sportsmed
JT  - The Physician and sportsmedicine
JID - 0427461
RN  - 0 (Anabolic Agents)
SB  - IM
MH  - Adolescent
MH  - Anabolic Agents/*administration & dosage/*adverse effects
MH  - *Athletic Performance
MH  - Doping in Sports/*prevention & control
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Humans
MH  - Male
MH  - Muscle, Skeletal/*drug effects
MH  - Societies, Medical
MH  - Substance Abuse Detection/methods
EDAT- 2010/10/21 06:00
MHDA- 2011/01/21 06:00
CRDT- 2010/10/21 06:00
PHST- 2010/10/21 06:00 [entrez]
PHST- 2010/10/21 06:00 [pubmed]
PHST- 2011/01/21 06:00 [medline]
AID - 10.3810/psm.2010.10.1815 [doi]
PST - ppublish
SO  - Phys Sportsmed. 2010 Oct;38(3):105-13. doi: 10.3810/psm.2010.10.1815.


PMID- 20959376
OWN - NLM
STAT- MEDLINE
DCOM- 20110209
LR  - 20211020
IS  - 1748-880X (Electronic)
IS  - 0007-1285 (Linking)
VI  - 84
IP  - 997
DP  - 2011 Jan
TI  - Dobutamine stress tagging and gradient-echo imaging for detection of coronary
      heart disease at 3 T.
PG  - 44-50
LID - 10.1259/bjr/59381313 [doi]
AB  - OBJECTIVE: The purpose of this study was to evaluate the feasibility and
      diagnostic accuracy of a combined spoiled gradient-echo (sGRE) and tagged
      gradient-echo (SPAMM-GRE) protocol for detection of coronary artery disease (CAD)
      during high-dose dobutamine stress at 3 T. METHOD: The study protocol was
      approved by the local ethics committee. For stress testing, a standard high-dose 
      dobutamine protocol was employed. Image quality at the highest stress level and
      diagnostic accuracy of the sGRE and SPAMM-GRE sequences were compared. The final 
      study population consisted of 37 patients. RESULTS: The mean image quality score 
      was 2.6+/-0.6 for the sGRE sequence and 2.4+/-0.6 for the SPAMM-GRE sequence
      (p>0.05). Sensitivity, specificity and diagnostic accuracy were 0.81, 0.86, 0.84 
      and 0.88, 0.86, 0.86 for the sGRE and SPAMM-GRE, respectively. In three cases
      with new wall motion abnormalities (WMAs), detected by sGRE and SPAMM-GRE, WMAs
      were detected at a lower stress level by tagging. CONCLUSION: The combined sGRE
      and SPAMM-GRE high-dose dobutamine protocol at 3 T is feasible and delivers good 
      diagnostic accuracy. Tagging increases the sensitivity of high-dose dobutamine
      stress testing for detection of CAD and may allow for detection of new WMAs at
      lower stress levels compared with sGRE alone.
FAU - Thomas, D
AU  - Thomas D
AD  - Department of Radiology, University of Bonn, Germany.
      daniel.thomas@ukb.uni-bonn.de
FAU - Meyer, C
AU  - Meyer C
FAU - Strach, K
AU  - Strach K
FAU - Naehle, C P
AU  - Naehle CP
FAU - Mazraeh, J
AU  - Mazraeh J
FAU - Gampert, T
AU  - Gampert T
FAU - Schild, H H
AU  - Schild HH
FAU - Sommer, T
AU  - Sommer T
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20101019
PL  - England
TA  - Br J Radiol
JT  - The British journal of radiology
JID - 0373125
RN  - 0 (Cardiotonic Agents)
RN  - 3S12J47372 (Dobutamine)
SB  - IM
MH  - *Cardiotonic Agents
MH  - Coronary Angiography/methods
MH  - Coronary Disease/*diagnosis
MH  - *Dobutamine
MH  - Echocardiography, Stress/*methods
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Sensitivity and Specificity
PMC - PMC3473814
EDAT- 2010/10/21 06:00
MHDA- 2011/02/10 06:00
CRDT- 2010/10/21 06:00
PHST- 2010/10/21 06:00 [entrez]
PHST- 2010/10/21 06:00 [pubmed]
PHST- 2011/02/10 06:00 [medline]
AID - 59381313 [pii]
AID - 10.1259/bjr/59381313 [doi]
PST - ppublish
SO  - Br J Radiol. 2011 Jan;84(997):44-50. doi: 10.1259/bjr/59381313. Epub 2010 Oct 19.


PMID- 20958941
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20220321
IS  - 1754-9485 (Electronic)
IS  - 1754-9477 (Linking)
VI  - 54
IP  - 5
DP  - 2010 Oct
TI  - Diagnostic yield of computed tomography of the brain in first episode psychosis.
PG  - 431-4
LID - 10.1111/j.1754-9485.2010.02196.x [doi]
AB  - INTRODUCTION: Brain computed tomography (CT) is inconsistently recommended
      worldwide in the investigative algorithm of patients presenting with first
      episode psychosis (FEP). The objective of this study is to investigate the
      clinical efficacy of brain CT in patients presenting with FEP without
      neurological signs in a major metropolitan teaching hospital. METHODS: The CT
      brain scan reports of 237 consecutive patients, for which the imaging requests or
      reports provided a history of FEP but no focal neurological signs, were
      retrospectively identified within a 6-year period in a 750-bed tertiary referral 
      teaching hospital using the radiology information system text-search function
      (170 male, 67 female; mean age, 28.3 years). All reports were authored or
      approved by consultant radiologist. They were reviewed for the presence of any
      lesion that could cause psychosis and hence alter clinical management. Minor
      neuroradiological abnormalities were also noted. Hospital Ethics Committee
      registration and approval were obtained and patient informed consent was not
      required. RESULTS: No focal brain lesion potentially responsible for the
      psychosis or focal lesion requiring surgical intervention was identified in any
      patient. Findings unable to be directly linked to the psychosis such as evidence 
      of small vessel ischaemic disease, arachnoid cysts, cerebral atrophy, and normal 
      variants were present in 17.6% of patients (45 of 237 studies), none of which led
      to an alteration of clinical management. CONCLUSION: The results of this study
      postulate that brain CT should not be universally performed in the initial
      assessment of patients with first episode psychosis without neurological signs.
CI  - (c) 2010 The Authors. Journal of Medical Imaging and Radiation Oncology (c) 2010 
      The Royal Australian and New Zealand College of Radiologists.
FAU - Strahl, Britta
AU  - Strahl B
AD  - Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.
FAU - Cheung, York K
AU  - Cheung YK
FAU - Stuckey, Stephen L
AU  - Stuckey SL
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Med Imaging Radiat Oncol
JT  - Journal of medical imaging and radiation oncology
JID - 101469340
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Brain/*diagnostic imaging
MH  - Brain Damage, Chronic/diagnostic imaging
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Psychotic Disorders/*diagnostic imaging
MH  - Retrospective Studies
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2010/10/21 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/10/21 06:00
PHST- 2010/10/21 06:00 [entrez]
PHST- 2010/10/21 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - 10.1111/j.1754-9485.2010.02196.x [doi]
PST - ppublish
SO  - J Med Imaging Radiat Oncol. 2010 Oct;54(5):431-4. doi:
      10.1111/j.1754-9485.2010.02196.x.


PMID- 20957215
OWN - NLM
STAT- MEDLINE
DCOM- 20101122
LR  - 20211020
IS  - 1177-8881 (Electronic)
IS  - 1177-8881 (Linking)
VI  - 4
DP  - 2010 Sep 24
TI  - Current and developing therapeutic agents in the treatment of Chagas disease.
PG  - 243-53
AB  - Chagas disease must be treated in all its stages: acute, indeterminate, chronic, 
      and initial and middle determinant chronic, due to the fact that DNA of the
      parasite can be demonstrated by PCR in chronic cases, where optical microscopy
      does not detect parasites. Nifurtimox (NF) and benznidazole (BNZ) are the drugs
      accepted to treat humans based upon ethical considerations and efficiency.
      However, both the drugs produce secondary effects in 30% of the cases, and the
      treatment must be given for at least 30-60 days. Other useful drugs are
      itraconazole and posaconazole. The latter may be the drug to treat Chagas disease
      in the future when all the investigations related to it are finished. At present,
      there is no criterion of cure for chronic cases since in the majority, the
      serology remains positive, although it may decrease. In acute cases, 70% cure
      with NF and 75% with BNZ is achieved. In congenital cases, 100% cure is obtained 
      if the treatment is performed during the first year of life. In chronic acquired 
      cases, 20% cure and 50% improvement of the electrocardiographic changes are
      obtained with itraconazole.
FAU - Apt, Werner
AU  - Apt W
AD  - University of Chile, Faculty of Medicine, Santiago, Chile. wapt@med.uchile.cl
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100924
PL  - New Zealand
TA  - Drug Des Devel Ther
JT  - Drug design, development and therapy
JID - 101475745
RN  - 0 (Nitroimidazoles)
RN  - 0 (Trypanocidal Agents)
RN  - M84I3K7C2O (Nifurtimox)
RN  - YC42NRJ1ZD (benzonidazole)
SB  - IM
MH  - Acute Disease
MH  - Animals
MH  - Chagas Disease/*drug therapy/parasitology
MH  - Chronic Disease
MH  - Humans
MH  - Nifurtimox/administration & dosage/adverse effects/therapeutic use
MH  - Nitroimidazoles/administration & dosage/adverse effects/therapeutic use
MH  - Time Factors
MH  - Treatment Outcome
MH  - Trypanocidal Agents/administration & dosage/adverse effects/*therapeutic use
PMC - PMC2948934
OTO - NOTNLM
OT  - Chagas disease
OT  - allopurinol
OT  - benznidazole
OT  - itraconazole
OT  - nifurtimox
OT  - posaconazole
OT  - treatment
EDAT- 2010/10/20 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/10/20 06:00
PHST- 2010/09/16 00:00 [received]
PHST- 2010/10/20 06:00 [entrez]
PHST- 2010/10/20 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.2147/dddt.s8338 [doi]
PST - epublish
SO  - Drug Des Devel Ther. 2010 Sep 24;4:243-53. doi: 10.2147/dddt.s8338.


PMID- 20957182
OWN - NLM
STAT- MEDLINE
DCOM- 20110202
LR  - 20211020
IS  - 1549-1676 (Electronic)
IS  - 1549-1277 (Linking)
VI  - 7
IP  - 10
DP  - 2010 Oct 5
TI  - A field training guide for human subjects research ethics.
LID - 10.1371/journal.pmed.1000349 [doi]
LID - e1000349 [pii]
FAU - Merritt, Maria W
AU  - Merritt MW
AD  - Department of International Health, Johns Hopkins Berman Institute of Bioethics, 
      Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United
      States of America. mmerritt@jhsph.edu
FAU - Labrique, Alain B
AU  - Labrique AB
FAU - Katz, Joanne
AU  - Katz J
FAU - Rashid, Mahbubur
AU  - Rashid M
FAU - West, Keith P Jr
AU  - West KP Jr
FAU - Pettit, Joan
AU  - Pettit J
LA  - eng
GR  - R01 ES015558/ES/NIEHS NIH HHS/United States
GR  - ES015558/ES/NIEHS NIH HHS/United States
GR  - HD061712/HD/NICHD NIH HHS/United States
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20101005
PL  - United States
TA  - PLoS Med
JT  - PLoS medicine
JID - 101231360
SB  - IM
MH  - *Education/methods/organization & administration
MH  - Education, Medical, Continuing/methods
MH  - *Guidelines as Topic
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - *Research Subjects
PMC - PMC2950122
EDAT- 2010/10/20 06:00
MHDA- 2011/02/03 06:00
CRDT- 2010/10/20 06:00
PHST- 2010/10/20 06:00 [entrez]
PHST- 2010/10/20 06:00 [pubmed]
PHST- 2011/02/03 06:00 [medline]
AID - 10.1371/journal.pmed.1000349 [doi]
PST - epublish
SO  - PLoS Med. 2010 Oct 5;7(10). doi: 10.1371/journal.pmed.1000349.


PMID- 20956920
OWN - NLM
STAT- MEDLINE
DCOM- 20110308
LR  - 20101019
IS  - 1319-6138 (Print)
IS  - 1319-6138 (Linking)
VI  - 15
IP  - 4
DP  - 2010 Oct
TI  - Assessment of autonomic function in epileptic patients.
PG  - 244-8
AB  - OBJECTIVE: To use spectral analysis to assess the autonomic activity of epileptic
      patients compared with normal patients, and to assess the clinical usefulness of 
      the applied methods of signal processing. METHODS: Forty-eight patients with
      generalized tonic-clonic seizures and who were not taking any medications, and 48
      age and gender matched controls participated in this study from July to September
      2007 at Johns Hopkins Hospital, Baltimore, Maryland, and the Medical Center,
      Cookeville, Tennessee, United States of America. All subjects consented to
      participate in the research prior to their inclusion in the study, and the local 
      ethics committee approved the study protocol. The study design was to measure
      peripheral blood flow (PBF) and respiration signals as well as the heart rate
      variability (HRV) signals derived from the ECG during supine and standing
      positions. RESULTS: The results clearly indicate that in patients with epilepsy, 
      the coherence values are less than in the control group in both low frequency and
      high frequency bands at coherence spectra between HRV and PBF as well as HRV and 
      respiration in both the supine and standing position. CONCLUSION: Autopower and
      coherence spectra analysis for patients with epilepsy compared to normal subjects
      seems useful in the assessment of autonomic function for epileptic patients.
      Further studies are needed using other tests and methods of signal analysis.
FAU - Kamal, Ahmed K
AU  - Kamal AK
AD  - Department of MIT, Tennessee Tech University, PO Box 5003, Lewis Hall,
      Cookeville, TN 38505, United States of America. akamal@tntech.edu
LA  - eng
PT  - Journal Article
PL  - Saudi Arabia
TA  - Neurosciences (Riyadh)
JT  - Neurosciences (Riyadh, Saudi Arabia)
JID - 101252453
SB  - IM
MH  - Autonomic Nervous System Diseases/*diagnosis/*etiology
MH  - Blood Pressure/physiology
MH  - Electrocardiography/methods
MH  - Epilepsy, Tonic-Clonic/*complications
MH  - Heart Rate/physiology
MH  - Humans
MH  - Male
MH  - Retrospective Studies
MH  - Spectrum Analysis
MH  - Young Adult
EDAT- 2010/10/20 06:00
MHDA- 2011/03/09 06:00
CRDT- 2010/10/20 06:00
PHST- 2010/10/20 06:00 [entrez]
PHST- 2010/10/20 06:00 [pubmed]
PHST- 2011/03/09 06:00 [medline]
AID - 20100189 [pii]
PST - ppublish
SO  - Neurosciences (Riyadh). 2010 Oct;15(4):244-8.


PMID- 20956890
OWN - NLM
STAT- MEDLINE
DCOM- 20110310
LR  - 20161020
IS  - 1022-4742 (Print)
IS  - 1022-4742 (Linking)
VI  - 19
IP  - 4
DP  - 2010 Oct
TI  - Genetic Testing for Huntington's Disease in Parkinsonism.
PG  - 510-4
AB  - The study was conducted to find out Huntington's disease (HD) by genetic analysis
      from those presenting with parkinsonism in the Neurology department of Mymensingh
      Medical College & Hospital. A sample of about 5ml blood was collected by veni
      puncture in EDTA tube with informed consent from 9 patients & 7 healthy
      individuals after approval of the institutional ethics committee for genetic
      study. The neurological disorder along with a complete history and physical
      findings were recorded in a prescribed questionnaire by the neurologists of
      Mymensingh Medical College & Hospital. Extraction of genomic DNA from the venous 
      blood using FlexiGene DNA kit (Qiagen, Japan) was performed in Faculty of
      Veterinary Science, Bangladesh Agricultural University, Mymensingh, Bangladesh.
      The extracted DNA was stored and accumulated and then these DNA were sent to
      Division of Clinical Genetics, Department of Medical Genetics, Osaka University
      Medical School, Suita, Osaka 565 0871, Japan for PCR and further analysis. PCR
      amplification of the CAG repeat in the 1T15 gene was performed with primers HD1
      and HD3. HD PCR products revealed the DNA product of about 110bp (no. of CAG
      repeats=21) to 150bp (no. of CAG repeats=34) in both healthy individual and
      suspected PD patient DNA.
FAU - Rahman, M S
AU  - Rahman MS
AD  - Professor MS Rahman, Professor and Head, Department of Medicine, Bangladesh
      Agricultural University (BAU), Mymensingh, Bangladesh.
FAU - Nagai, Y
AU  - Nagai Y
FAU - Popiel, H A
AU  - Popiel HA
FAU - Fujikake, N
AU  - Fujikake N
FAU - Okamoto, Y
AU  - Okamoto Y
FAU - Ahmed, M U
AU  - Ahmed MU
FAU - Islam, M A
AU  - Islam MA
FAU - Islam, M T
AU  - Islam MT
FAU - Ahmed, S
AU  - Ahmed S
FAU - Rahman, K M
AU  - Rahman KM
FAU - Uddin, M J
AU  - Uddin MJ
FAU - Dey, S K
AU  - Dey SK
FAU - Ahmed, Q
AU  - Ahmed Q
FAU - Hossain, M A
AU  - Hossain MA
FAU - Jahan, N
AU  - Jahan N
FAU - Toda, T
AU  - Toda T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Bangladesh
TA  - Mymensingh Med J
JT  - Mymensingh medical journal : MMJ
JID - 9601799
SB  - IM
MH  - *Genetic Testing
MH  - Humans
MH  - Huntington Disease/*genetics
MH  - Parkinsonian Disorders/*genetics
MH  - Polymerase Chain Reaction
MH  - Trinucleotide Repeats
EDAT- 2010/10/20 06:00
MHDA- 2011/03/11 06:00
CRDT- 2010/10/20 06:00
PHST- 2010/10/20 06:00 [entrez]
PHST- 2010/10/20 06:00 [pubmed]
PHST- 2011/03/11 06:00 [medline]
PST - ppublish
SO  - Mymensingh Med J. 2010 Oct;19(4):510-4.


PMID- 20956043
OWN - NLM
STAT- MEDLINE
DCOM- 20110413
LR  - 20220408
IS  - 1873-1570 (Electronic)
IS  - 0300-9572 (Linking)
VI  - 81
IP  - 10
DP  - 2010 Oct
TI  - European Resuscitation Council Guidelines for Resuscitation 2010 Section 10. The 
      ethics of resuscitation and end-of-life decisions.
PG  - 1445-51
LID - 10.1016/j.resuscitation.2010.08.013 [doi]
FAU - Lippert, Freddy K
AU  - Lippert FK
AD  - The Capital Region of Denmark, Copenhagen, Denmark. lippert@regionh.dk
FAU - Raffay, Violetta
AU  - Raffay V
FAU - Georgiou, Marios
AU  - Georgiou M
FAU - Steen, Petter A
AU  - Steen PA
FAU - Bossaert, Leo
AU  - Bossaert L
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Resuscitation
JT  - Resuscitation
JID - 0332173
SB  - IM
MH  - Cardiopulmonary Resuscitation/*ethics/psychology/standards
MH  - Clinical Protocols/standards
MH  - Death, Sudden, Cardiac/prevention & control
MH  - Prognosis
MH  - Quality of Life/psychology
MH  - Quality-Adjusted Life Years
MH  - Resuscitation Orders/*ethics/legislation & jurisprudence/psychology
MH  - Survivors/legislation & jurisprudence/psychology
EDAT- 2010/10/20 06:00
MHDA- 2011/04/14 06:00
CRDT- 2010/10/20 06:00
PHST- 2010/10/20 06:00 [entrez]
PHST- 2010/10/20 06:00 [pubmed]
PHST- 2011/04/14 06:00 [medline]
AID - S0300-9572(10)00439-9 [pii]
AID - 10.1016/j.resuscitation.2010.08.013 [doi]
PST - ppublish
SO  - Resuscitation. 2010 Oct;81(10):1445-51. doi: 10.1016/j.resuscitation.2010.08.013.


PMID- 20955923
OWN - NLM
STAT- MEDLINE
DCOM- 20101108
LR  - 20211020
IS  - 1097-4199 (Electronic)
IS  - 0896-6273 (Linking)
VI  - 68
IP  - 2
DP  - 2010 Oct 21
TI  - Healing genes in the nervous system.
PG  - 178-81
LID - 10.1016/j.neuron.2010.10.005 [doi]
AB  - The evolution of gene therapy has led to the development of promising new
      therapeutic approaches. This NeuroView will introduce the variety of delivery
      vehicles currently available for gene therapy, a range of preclinical strategies 
      for tackling major diseases of the nervous system, the clinical limitations, and 
      ethical considerations.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Breakefield, Xandra O
AU  - Breakefield XO
AD  - Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 
      Boston, MA 02114, USA. breakefield@hms.harvard.edu
FAU - Sena-Esteves, Miguel
AU  - Sena-Esteves M
LA  - eng
GR  - R01 NS066310/NS/NINDS NIH HHS/United States
GR  - P01 CA069246/CA/NCI NIH HHS/United States
GR  - R01 HD060576/HD/NICHD NIH HHS/United States
GR  - U01 NS064096/NS/NINDS NIH HHS/United States
GR  - U01NS064096/NS/NINDS NIH HHS/United States
GR  - NS24279/NS/NINDS NIH HHS/United States
GR  - R01HD060576/HD/NICHD NIH HHS/United States
GR  - P01 NS024279-23/NS/NINDS NIH HHS/United States
GR  - R01NS066310/NS/NINDS NIH HHS/United States
GR  - P01 NS024279/NS/NINDS NIH HHS/United States
GR  - P01 NS037409/NS/NINDS NIH HHS/United States
GR  - CA069246/CA/NCI NIH HHS/United States
GR  - NS037409/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
SB  - IM
MH  - Animals
MH  - Gene Transfer Techniques
MH  - Genetic Therapy/*methods
MH  - Humans
MH  - Nervous System/*metabolism
MH  - *Nervous System Diseases/genetics/pathology/therapy
PMC - PMC3076203
MID - NIHMS270465
EDAT- 2010/10/20 06:00
MHDA- 2010/11/09 06:00
CRDT- 2010/10/20 06:00
PHST- 2010/10/20 06:00 [entrez]
PHST- 2010/10/20 06:00 [pubmed]
PHST- 2010/11/09 06:00 [medline]
AID - S0896-6273(10)00829-9 [pii]
AID - 10.1016/j.neuron.2010.10.005 [doi]
PST - ppublish
SO  - Neuron. 2010 Oct 21;68(2):178-81. doi: 10.1016/j.neuron.2010.10.005.


PMID- 20955659
OWN - NLM
STAT- MEDLINE
DCOM- 20110131
LR  - 20101019
IS  - 1555-3892 (Electronic)
IS  - 0963-6897 (Linking)
VI  - 19
IP  - 6
DP  - 2010
TI  - Hepatic differentiation of mouse iPS cells in vitro.
PG  - 841-7
LID - 10.3727/096368910X508960 [doi]
AB  - Induced pluripotent stem (iPS) cells are pluripotent and are able to unlimitedly 
      proliferate in vitro. This technical breakthrough in creating iPS cells from
      somatic cells has noteworthy implications for overcoming the immunological
      rejection and the ethical issues associated with the derivation of embryonic stem
      cells from embryos. In the current work, we present an efficient hepatic
      differentiation of mouse iPS cells in vitro. iPS cells were cultured free
      floating to induce the formation of embryoid bodies (EB) for 5 days. EB were
      transferred to a gelatin-coated plate and treated with 100 ng/ml activin A and
      100 ng/ml basic fibroblast growth factor (bFGF) for 3 days to induce definitive
      endoderm. Cells were further cultured for 8 days with 100 ng/ml hepatocyte growth
      factor (HGF) to generate hepatocytes. Characterization was performed by RT-PCR
      assay. Functional analysis for albumin secretion and ammonia removal was also
      carried out. iPS cell-derived hepatocyte-like cells (iPS-Heps) were obtained at
      the end of the differentiation program. Expression levels of a gestational
      hepatocyte gene and lineage-specific hepatic genes intensified in iPS-Heps. The
      production of albumin increased in a time-dependent manner. iPS-Heps were capable
      of metabolizing ammonia. We present here instant hepatic differentiation of mouse
      iPS cells using combined 3-day treatments of activin A and bFGF with subsequent
      8-day HGF. Our study will be an important step to generate hepatocytes from human
      iPS cells as a new source for liver-targeted cell therapies.
FAU - Iwamuro, Masaya
AU  - Iwamuro M
AD  - Department of Gastroenterology and Hepatology, Okayama University Graduate School
      of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
      iwamuromasaya@yahoo.co.jp
FAU - Komaki, Toshiyuki
AU  - Komaki T
FAU - Kubota, Yasuhiro
AU  - Kubota Y
FAU - Seita, Masayuki
AU  - Seita M
FAU - Kawamoto, Hironobu
AU  - Kawamoto H
FAU - Yuasa, Takeshi
AU  - Yuasa T
FAU - Shahid, Javed M
AU  - Shahid JM
FAU - Hassan, Reham A R A
AU  - Hassan RA
FAU - Hassan, Wael A R A
AU  - Hassan WA
FAU - Nakaji, Shuhei
AU  - Nakaji S
FAU - Nishikawa, Yuriko
AU  - Nishikawa Y
FAU - Kondo, Eisaku
AU  - Kondo E
FAU - Yamamoto, Kazuhide
AU  - Yamamoto K
FAU - Fox, Ira J
AU  - Fox IJ
FAU - Kobayashi, Naoya
AU  - Kobayashi N
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cell Transplant
JT  - Cell transplantation
JID - 9208854
RN  - 0 (Albumins)
RN  - 0 (activin A)
RN  - 103107-01-3 (Fibroblast Growth Factor 2)
RN  - 104625-48-1 (Activins)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - 7664-41-7 (Ammonia)
SB  - IM
MH  - Activins/pharmacology
MH  - Albumins/genetics/metabolism
MH  - Ammonia/metabolism
MH  - Animals
MH  - *Cell Differentiation/drug effects
MH  - Cell Line
MH  - Cell Shape/drug effects
MH  - Cells, Cultured
MH  - Fibroblast Growth Factor 2/pharmacology
MH  - Gene Expression Regulation/drug effects
MH  - Hepatocyte Growth Factor/pharmacology
MH  - Hepatocytes/cytology/drug effects/metabolism
MH  - Induced Pluripotent Stem Cells/*cytology/drug effects/metabolism
MH  - Liver/*cytology/drug effects/metabolism
MH  - Mice
EDAT- 2010/10/20 06:00
MHDA- 2011/02/01 06:00
CRDT- 2010/10/20 06:00
PHST- 2010/10/20 06:00 [entrez]
PHST- 2010/10/20 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
AID - 10.3727/096368910X508960 [doi]
PST - ppublish
SO  - Cell Transplant. 2010;19(6):841-7. doi: 10.3727/096368910X508960.


PMID- 20955626
OWN - NLM
STAT- MEDLINE
DCOM- 20110215
LR  - 20211020
IS  - 1471-2121 (Electronic)
IS  - 1471-2121 (Linking)
VI  - 11
DP  - 2010 Oct 19
TI  - A novel method to derive amniotic fluid stem cells for therapeutic purposes.
PG  - 79
LID - 10.1186/1471-2121-11-79 [doi]
AB  - BACKGROUND: Human amniotic fluid stem (hAFS) cells have become an attractive stem
      cell source for medical therapy due to both their ability to propagate as stem
      cells and the lack of ethical debate that comes with the use of embryonic stem
      cells. Although techniques to derive stem cells from amniotic fluid are
      available, the techniques have limitations for clinical uses, including a
      requirement of long periods of time for stem cell production, population
      heterogeneity and xeno-contamination from using animal antibody-coated magnetic
      beads. Herein we describe a novel isolation method that fits for hAFS derivation 
      for cell-based therapy. METHODS AND RESULTS: With our method, single hAFS cells
      generate colonies in a primary culture of amniotic fluid cells. Individual hAFS
      colonies are then expanded by subculturing in order to make a clonal hAFS cell
      line. This method allows derivation of a substantial amount of a pure stem cell
      population within a short period of time. Indeed, 108 cells from a clonal hAFS
      line can be derived in two weeks using our method, while previous techniques
      require two months. The resultant hAFS cells show a 2-5 times greater
      proliferative ability than with previous techniques and a population doubling
      time of 0.8 days. The hAFS cells exhibit typical hAFS cell characteristics
      including the ability to differentiate into adipogenic-, osteogenic- and
      neurogenic lineages, expression of specific stem cell markers including Oct4,
      SSEA4, CD29, CD44, CD73, CD90, CD105 and CD133, and maintenance of a normal
      karyotype over long culture periods. CONCLUSIONS: We have created a novel hAFS
      cell derivation method that can produce a vast amount of high quality stem cells 
      within a short period of time. Our technique makes possibility for providing
      autogenic fetal stem cells and allogeneic cells for future cell-based therapy.
FAU - Phermthai, Tatsanee
AU  - Phermthai T
AD  - Stem Cell Research and Development Unit, Department of Obstetrics & Gynecology,
      Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700,
      Thailand. sitsu@mahidol.ac.th
FAU - Odglun, Yuparat
AU  - Odglun Y
FAU - Julavijitphong, Suphakde
AU  - Julavijitphong S
FAU - Titapant, Vitaya
AU  - Titapant V
FAU - Chuenwattana, Prakong
AU  - Chuenwattana P
FAU - Vantanasiri, Chanchai
AU  - Vantanasiri C
FAU - Pattanapanyasat, Kovit
AU  - Pattanapanyasat K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101019
PL  - England
TA  - BMC Cell Biol
JT  - BMC cell biology
JID - 100966972
RN  - 0 (Intermediate Filament Proteins)
RN  - 0 (NES protein, human)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Nestin)
RN  - 0 (Tubulin)
SB  - IM
MH  - Amniotic Fluid/*cytology
MH  - Cell Separation/*methods
MH  - Chromosomal Instability
MH  - Female
MH  - Gestational Age
MH  - Humans
MH  - Intermediate Filament Proteins/genetics/metabolism
MH  - Karyotyping
MH  - Nerve Tissue Proteins/genetics/metabolism
MH  - Nestin
MH  - Pregnancy
MH  - Stem Cells/*cytology/metabolism
MH  - Tubulin/genetics/metabolism
PMC - PMC2973936
EDAT- 2010/10/20 06:00
MHDA- 2011/02/16 06:00
CRDT- 2010/10/20 06:00
PHST- 2010/02/04 00:00 [received]
PHST- 2010/10/19 00:00 [accepted]
PHST- 2010/10/20 06:00 [entrez]
PHST- 2010/10/20 06:00 [pubmed]
PHST- 2011/02/16 06:00 [medline]
AID - 1471-2121-11-79 [pii]
AID - 10.1186/1471-2121-11-79 [doi]
PST - epublish
SO  - BMC Cell Biol. 2010 Oct 19;11:79. doi: 10.1186/1471-2121-11-79.


PMID- 20955582
OWN - NLM
STAT- MEDLINE
DCOM- 20110110
LR  - 20211020
IS  - 1471-2458 (Electronic)
IS  - 1471-2458 (Linking)
VI  - 10
DP  - 2010 Oct 18
TI  - Effectiveness and cost-effectiveness of early assisted discharge for chronic
      obstructive pulmonary disease exacerbations: the design of a randomised
      controlled trial.
PG  - 618
LID - 10.1186/1471-2458-10-618 [doi]
AB  - BACKGROUND: Exacerbations of chronic obstructive pulmonary disease (COPD) are the
      main cause for hospitalisation. These hospitalisations result in a high pressure 
      on hospital beds and high health care costs. Because of the increasing prevalence
      of COPD this will only become worse. Hospital at home is one of the alternatives 
      that has been proved to be a safe alternative for hospitalisation in COPD. Most
      schemes are early assisted discharge schemes with specialised respiratory nurses 
      providing care at home. Whether this type of service is cost-effective depends on
      the setting in which it is delivered and the way in which it is organised.
      METHODS/DESIGN: GO AHEAD (Assessment Of Going Home under Early Assisted
      Discharge) is a 3-months, randomised controlled, multi-centre clinical trial.
      Patients admitted to hospital for a COPD exacerbation are either discharged on
      the fourth day of admission and further treated at home, or receive usual
      inpatient hospital care. Home treatment is supervised by general nurses. Primary 
      outcome is the effectiveness and cost effectiveness of an early assisted
      discharge intervention in comparison with usual inpatient hospital care for
      patients hospitalised with a COPD exacerbation. Secondary outcomes include
      effects on quality of life, primary informal caregiver burden and patient and
      primary caregiver satisfaction. Additionally, a discrete choice experiment is
      performed to provide insight in patient and informal caregiver preferences for
      different treatment characteristics. Measurements are performed on the first day 
      of admission and 3 days, 7 days, 1 month and 3 months thereafter. Ethical
      approval has been obtained and the study has been registered. DISCUSSION: This
      article describes the study protocol of the GO AHEAD study. Early assisted
      discharge could be an effective and cost-effective method to reduce length of
      hospital stay in the Netherlands which is beneficial for patients and society. If
      effectiveness and cost-effectiveness can be proven, implementation in the Dutch
      health care system should be considered. TRIAL REGISTRATION: Netherlands Trial
      Register NTR1129.
FAU - Utens, Cecile M A
AU  - Utens CM
AD  - Department of Respiratory Medicine, Catharina Hospital Eindhoven, Eindhoven, the 
      Netherlands. cecile.utens@cze.nl
FAU - Goossens, Lucas M A
AU  - Goossens LM
FAU - Smeenk, Frank W J M
AU  - Smeenk FW
FAU - van Schayck, Onno C P
AU  - van Schayck OC
FAU - van Litsenburg, Walter
AU  - van Litsenburg W
FAU - Janssen, Annet
AU  - Janssen A
FAU - van Vliet, Monique
AU  - van Vliet M
FAU - Seezink, Wiel
AU  - Seezink W
FAU - Demunck, Dirk R A J
AU  - Demunck DR
FAU - van de Pas, Brigitte
AU  - van de Pas B
FAU - de Bruijn, Peter J
AU  - de Bruijn PJ
FAU - van der Pouw, Anouschka
AU  - van der Pouw A
FAU - Retera, Jeroen M A M
AU  - Retera JM
FAU - de Laat-Bierings, Petra
AU  - de Laat-Bierings P
FAU - van Eijsden, Loes
AU  - van Eijsden L
FAU - Braken, Maria
AU  - Braken M
FAU - Eijsermans, Riet
AU  - Eijsermans R
FAU - Rutten-van Molken, Maureen P M H
AU  - Rutten-van Molken MP
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20101018
PL  - England
TA  - BMC Public Health
JT  - BMC public health
JID - 100968562
SB  - IM
MH  - Adult
MH  - Cost-Benefit Analysis
MH  - Female
MH  - Home Care Services
MH  - Humans
MH  - Length of Stay
MH  - Male
MH  - Netherlands
MH  - Patient Discharge/*economics/standards
MH  - Program Evaluation
MH  - Pulmonary Disease, Chronic Obstructive/*physiopathology
MH  - Research Design
MH  - Sample Size
MH  - Surveys and Questionnaires
PMC - PMC2965725
EDAT- 2010/10/20 06:00
MHDA- 2011/01/11 06:00
CRDT- 2010/10/20 06:00
PHST- 2010/10/07 00:00 [received]
PHST- 2010/10/18 00:00 [accepted]
PHST- 2010/10/20 06:00 [entrez]
PHST- 2010/10/20 06:00 [pubmed]
PHST- 2011/01/11 06:00 [medline]
AID - 1471-2458-10-618 [pii]
AID - 10.1186/1471-2458-10-618 [doi]
PST - epublish
SO  - BMC Public Health. 2010 Oct 18;10:618. doi: 10.1186/1471-2458-10-618.


PMID- 20955541
OWN - NLM
STAT- MEDLINE
DCOM- 20110218
LR  - 20181201
IS  - 1755-5922 (Electronic)
IS  - 1755-5914 (Linking)
VI  - 28
IP  - 6
DP  - 2010 Dec
TI  - Statins alter intracellular calcium homeostasis in malignant hyperthermia
      susceptible individuals.
PG  - 356-60
LID - 10.1111/j.1755-5922.2010.00237.x [doi]
AB  - AIMS: Statines, HMG-CoA reductase inhibitors, are widely used to treat
      hypercholesterinemia. These substances are well tolerated, but myotoxic effects
      have been reported. The exact mechanisms of the induced myotoxicity are unknown
      but an involvement of intracellular calcium handling is suspected. Individuals
      susceptible to malignant hyperthermia (MH) have an impaired calcium homeostasis. 
      An in vitro test measuring contracture responses of isolated muscle bundles is
      used to investigate cellular processes of MH. Aim of this study was to
      investigate if statins modify the contracture response of isolated muscle bundles
      from MH susceptible (MHS) and nonsusceptible (MHN) pigs. METHODOLOGY: With
      approval of the local ethics committee muscle biopsies of 18 MH susceptible and
      12 nonsusceptible pigs were performed. Muscle bundles were mounted on an
      isometric force transducer, preloaded, and electrically stimulated. After
      establishment of a stable baseline, muscle bundles were exposed to simvastatin,
      atorvastatin, gemfibrocil, and the pure solvent. Baseline tension was measured
      and analyzed for changes with P < 0.05 considered to be significant. RESULTS:
      There were no differences in weight, length, and predrug baseline tension between
      the groups. Both simvastatin and atorvastatin induced significant contractures in
      muscle bundles from MHS pigs. Gemfibrocil and the solvent methanol showed no
      effect. In MHN muscle bundles, none of the tested substances induced a
      contracture. Statines induce contractures only in MHS muscle bundles. CONCLUSION:
      We therefore conclude that the underlying mechanism may be a pathologic influence
      on intracellular calcium handling that is absent in MHN. A preexisting impairment
      of the calcium homeostasis seems to be necessary for this behavior because muscle
      bundles of MHN pigs showed no pathologic reaction. A higher muscle cell
      vulnerability toward statins is assumed in MHS patients. Statins ought to be used
      with caution in these individuals. Analogous a diagnostic workup for MH should be
      considered for patients with statin-induced rhabdomyolyis.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Metterlein, T
AU  - Metterlein T
AD  - Department of Anesthesiology, University Hospital Wuerzburg, Wuerzburg, Germany. 
      tom.metterlein@gmx.net
FAU - Schuster, F
AU  - Schuster F
FAU - Tadda, L
AU  - Tadda L
FAU - Hager, M
AU  - Hager M
FAU - Roewer, N
AU  - Roewer N
FAU - Anetseder, M
AU  - Anetseder M
LA  - eng
PT  - Journal Article
DEP - 20101019
PL  - England
TA  - Cardiovasc Ther
JT  - Cardiovascular therapeutics
JID - 101319630
RN  - 0 (Heptanoic Acids)
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
RN  - 0 (Pyrroles)
RN  - A0JWA85V8F (Atorvastatin)
RN  - AGG2FN16EV (Simvastatin)
RN  - Q8X02027X3 (Gemfibrozil)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Atorvastatin
MH  - Biopsy
MH  - Calcium/*metabolism
MH  - Electric Stimulation
MH  - Female
MH  - Gemfibrozil/pharmacology
MH  - Genotype
MH  - Heptanoic Acids/*toxicity
MH  - Homeostasis
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/*toxicity
MH  - In Vitro Techniques
MH  - Isometric Contraction/*drug effects
MH  - Male
MH  - Malignant Hyperthermia/complications/genetics/*metabolism/physiopathology
MH  - Muscle, Skeletal/*drug effects/metabolism/physiopathology
MH  - Phenotype
MH  - Pyrroles/*toxicity
MH  - Rhabdomyolysis/*chemically induced/metabolism/physiopathology
MH  - Simvastatin/*toxicity
MH  - Swine
MH  - Time Factors
EDAT- 2010/10/20 06:00
MHDA- 2011/02/22 06:00
CRDT- 2010/10/20 06:00
PHST- 2010/10/20 06:00 [entrez]
PHST- 2010/10/20 06:00 [pubmed]
PHST- 2011/02/22 06:00 [medline]
AID - 10.1111/j.1755-5922.2010.00237.x [doi]
PST - ppublish
SO  - Cardiovasc Ther. 2010 Dec;28(6):356-60. doi: 10.1111/j.1755-5922.2010.00237.x.
      Epub 2010 Oct 19.


PMID- 20955295
OWN - NLM
STAT- MEDLINE
DCOM- 20110228
LR  - 20211203
IS  - 1399-3089 (Electronic)
IS  - 0908-665X (Linking)
VI  - 17
IP  - 5
DP  - 2010 Sep-Oct
TI  - Korean attitudes to Xenotransplantation: a survey conducted in 2009.
PG  - 391-5
LID - 10.1111/j.1399-3089.2010.00604.x [doi]
AB  - BACKGROUND: Xenotransplantation research has been being actively conducted in
      Korea. However, there are numbers of socio-ethical issues involved in this
      research, and it is necessary to know public attitudes toward the research,
      inducing "public consensus" for the sound development of the technology.
      MATERIALS AND METHODS: A telephone survey consisting of 10 questionnaire items
      was conducted to investigate the attitudes of Koreans on social and ethical
      issues related to xenotransplantation. Participants were randomly selected in
      proportion to the 2009 Korean population census. The response rate was 22.3%.
      Finally, 500 sets of data were collected and analyzed with SPSS(R) 12. A
      statistical analysis was performed using the chi-square test. RESULTS: In the
      first phase of the study, 69.8% of the respondents were positive about
      xenotransplantation while 29.0% were negative. However, after being informed of
      the specific benefit and risk, 58.4% of the respondents stated that
      xenotransplantation research should be continued, while 38.6% of them indicated
      that these studies should be prohibited; 63.0% of the respondents agreed with
      lifelong surveillance after xenotransplantation, while 34.0% disagreed. To avoid 
      triggering immune response in the transplantees, 63.0% of the respondents also
      approved of the necessity of genetic modification of pigs. If xenotransplantation
      proves to be safe, 56.8% of the respondents said that they would accept it if
      necessary; 69.8% of the respondents would recommend it for their family members
      and friends as a therapeutic option if they are in need. Men were more positive
      than women about the necessity of animal experimentation for xenotransplantation 
      research, the necessity of lifelong surveillance, and the necessity of genetic
      modification of pigs. There was no significant difference between the religious
      and non-religious group except about the issue of lifelong surveillance.
      CONCLUSION: Korean people have relatively positive attitudes toward
      xenotransplantation research and animal experiments regarding
      xenotransplantation.
CI  - (c) 2010 John Wiley & Sons A/S.
FAU - Mo, Hyojung
AU  - Mo H
AD  - Department of Medical Education, School of Medicine, Ewha Womans University,
      Seoul, Korea.
FAU - Kwon, Ivo
AU  - Kwon I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Xenotransplantation
JT  - Xenotransplantation
JID - 9438793
SB  - IM
MH  - Adult
MH  - Asians/*psychology
MH  - *Attitude
MH  - *Data Collection
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Public Opinion
MH  - Republic of Korea
MH  - Research
MH  - Surveys and Questionnaires
MH  - Telephone
MH  - Transplantation, Heterologous/*psychology
MH  - Young Adult
EDAT- 2010/10/20 06:00
MHDA- 2011/03/01 06:00
CRDT- 2010/10/20 06:00
PHST- 2010/10/20 06:00 [entrez]
PHST- 2010/10/20 06:00 [pubmed]
PHST- 2011/03/01 06:00 [medline]
AID - 10.1111/j.1399-3089.2010.00604.x [doi]
PST - ppublish
SO  - Xenotransplantation. 2010 Sep-Oct;17(5):391-5. doi:
      10.1111/j.1399-3089.2010.00604.x.


PMID- 20954535
OWN - NLM
STAT- MEDLINE
DCOM- 20101102
LR  - 20211203
IS  - 0883-5381 (Print)
IS  - 0883-5381 (Linking)
VI  - 25
IP  - 5
DP  - 2010 Sep-Oct
TI  - Addressing racial and ethnic disparities in healthcare. Senior management has an 
      ethical responsibility to take a leadership role.
PG  - 46, 48, 50
FAU - Hofmann, Paul B
AU  - Hofmann PB
AD  - Hofmann Healthcare Group, Moraga, CA 94556, USA. hofmann@hofmannhealth.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Healthc Exec
JT  - Healthcare executive
JID - 8612808
MH  - *Healthcare Disparities
MH  - Hospital Administrators/*ethics
MH  - Humans
MH  - *Leadership
MH  - *Professional Role
MH  - *Racial Groups
MH  - United States
EDAT- 2010/10/20 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/10/20 06:00
PHST- 2010/10/20 06:00 [entrez]
PHST- 2010/10/20 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
PST - ppublish
SO  - Healthc Exec. 2010 Sep-Oct;25(5):46, 48, 50.


PMID- 20953757
OWN - NLM
STAT- MEDLINE
DCOM- 20110308
LR  - 20211020
IS  - 1433-0407 (Electronic)
IS  - 0028-2804 (Linking)
VI  - 81
IP  - 11
DP  - 2010 Nov
TI  - [Psychiatry during National Socialism: historical knowledge, implications for
      present day ethical debates].
PG  - 1317-8, 1320-2, 1324-5
LID - 10.1007/s00115-010-3051-3 [doi]
AB  - This contribution is a synthesis of the results of historical research on
      psychiatry during the Nazi period and some implications for present day debates
      in medical ethics. The focus is on three issues: the relationship between
      physicians and the state, the impact of eugenically and economically motivated
      health and social policies for psychiatry (e.g. forced sterilization, patient
      killing/euthanasia) and psychiatric research. Three myths are deconstructed: 1)
      that medical atrocities were imposed from above by Nazi politicians on apolitical
      physicians, 2) that mass sterilization and patient killing had nothing to do with
      contemporary state of the art of medical reasoning and practice and 3) that
      ethically unacceptable research on psychiatric patients had nothing to do with
      the contemporary state of the art of biomedical sciences. It is argued that the
      findings on these issues of Nazi medicine are not specific to Germany and the
      period between 1933 and 1945 but they were the extreme manifestations of some
      potential problems implicit in modern medicine in general.
FAU - Roelcke, V
AU  - Roelcke V
AD  - Institut fur Geschichte der Medizin, Universitat Giessen, Jheringstrasse 6,
      35392, Giessen, Deutschland. volker.roelcke@histor.med.uni-giessen.de
LA  - ger
PT  - English Abstract
PT  - Historical Article
PT  - Journal Article
TT  - Psychiatrie im Nationalsozialismus : Historische Kenntnisse, Implikationen fur
      aktuelle ethische Debatten.
PL  - Germany
TA  - Nervenarzt
JT  - Der Nervenarzt
JID - 0400773
SB  - IM
MH  - Ethics, Medical/*history
MH  - Eugenics/*history
MH  - Germany
MH  - History, 20th Century
MH  - National Socialism/*history
MH  - Physician's Role/*history
MH  - Psychiatry/*ethics/*history
EDAT- 2010/10/19 06:00
MHDA- 2011/03/09 06:00
CRDT- 2010/10/19 06:00
PHST- 2010/10/19 06:00 [entrez]
PHST- 2010/10/19 06:00 [pubmed]
PHST- 2011/03/09 06:00 [medline]
AID - 10.1007/s00115-010-3051-3 [doi]
PST - ppublish
SO  - Nervenarzt. 2010 Nov;81(11):1317-8, 1320-2, 1324-5. doi:
      10.1007/s00115-010-3051-3.


PMID- 20953291
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1662-5161 (Electronic)
IS  - 1662-5161 (Linking)
VI  - 4
DP  - 2010
TI  - Reducing barriers to ethics in neuroscience.
LID - 10.3389/fnhum.2010.00167 [doi]
LID - 167 [pii]
AB  - Ethics is a growing interest for neuroscientists, but rather than signifying a
      commitment to the protection of human subjects, care of animals, and public
      understanding to which the professional community is engaged in a fundamental
      way, interest has been consumed by administrative overhead and the mission creep 
      of institutional ethics reviews. Faculty, trainees, and staff (n = 605) in North 
      America whose work involves brain imaging and brain stimulation completed an
      online survey about ethics in their research. Using factor analysis and linear
      regression, we found significant effects for invasiveness of imaging technique,
      professional position, gender, and local presence of bioethics centers. We
      propose strategies for improving communication between the neuroscience community
      and ethics review boards, collaborations between neuroscientists and biomedical
      ethicists, and ethics training in graduate neuroscience programs to revitalize
      mutual goals and interests.
FAU - Illes, Judy
AU  - Illes J
AD  - National Core for Neuroethics, Division of Neurology, Department of Medicine, The
      University of British Columbia Vancouver, BC, Canada.
FAU - Tairyan, Kate
AU  - Tairyan K
FAU - Federico, Carole A
AU  - Federico CA
FAU - Tabet, Aline
AU  - Tabet A
FAU - Glover, Gary H
AU  - Glover GH
LA  - eng
GR  - R01 MH084282/MH/NIMH NIH HHS/United States
PT  - Journal Article
DEP - 20101004
PL  - Switzerland
TA  - Front Hum Neurosci
JT  - Frontiers in human neuroscience
JID - 101477954
PMC - PMC2955400
OTO - NOTNLM
OT  - ethics
OT  - neuroethics
OT  - neuroimaging
EDAT- 2010/10/19 06:00
MHDA- 2010/10/19 06:01
CRDT- 2010/10/19 06:00
PHST- 2010/05/03 00:00 [received]
PHST- 2010/07/29 00:00 [accepted]
PHST- 2010/10/19 06:00 [entrez]
PHST- 2010/10/19 06:00 [pubmed]
PHST- 2010/10/19 06:01 [medline]
AID - 10.3389/fnhum.2010.00167 [doi]
PST - epublish
SO  - Front Hum Neurosci. 2010 Oct 4;4. doi: 10.3389/fnhum.2010.00167. eCollection
      2010.


PMID- 20952836
OWN - NLM
STAT- MEDLINE
DCOM- 20110201
LR  - 20211020
IS  - 1998-3689 (Electronic)
IS  - 0301-4738 (Linking)
VI  - 58
IP  - 6
DP  - 2010 Nov-Dec
TI  - Principles of sample size calculation.
PG  - 517-8
LID - 10.4103/0301-4738.71692 [doi]
AB  - In most areas in life, it is difficult to work with populations and hence
      researchers work with samples. The calculation of the sample size needed depends 
      on the data type and distribution. Elements include consideration of the alpha
      error, beta error, clinically meaningful difference, and the variability or
      standard deviation. The final number arrived at should be increased to include a 
      safety margin and the dropout rate. Over and above this, sample size calculations
      must take into account all available data, funding, support facilities, and
      ethics of subjecting patients to research.
FAU - Gogtay, Nithya J
AU  - Gogtay NJ
AD  - Department of Clinical Pharmacology, Seth GS Medical College and KEM Hospital,
      Parel, Mumbai, Maharashtra, India. njgogtay@hotmail.com
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Ophthalmol
JT  - Indian journal of ophthalmology
JID - 0405376
SB  - IM
CIN - Indian J Ophthalmol. 2012 Nov-Dec;60(6):582; discussion 582. PMID: 23202412
MH  - *Clinical Trials as Topic
MH  - Data Interpretation, Statistical
MH  - Humans
MH  - *Sample Size
PMC - PMC2993982
EDAT- 2010/10/19 06:00
MHDA- 2011/02/02 06:00
CRDT- 2010/10/19 06:00
PHST- 2010/10/19 06:00 [entrez]
PHST- 2010/10/19 06:00 [pubmed]
PHST- 2011/02/02 06:00 [medline]
AID - IndianJOphthalmol_2010_58_6_517_71692 [pii]
AID - 10.4103/0301-4738.71692 [doi]
PST - ppublish
SO  - Indian J Ophthalmol. 2010 Nov-Dec;58(6):517-8. doi: 10.4103/0301-4738.71692.


PMID- 20952805
OWN - NLM
STAT- MEDLINE
DCOM- 20160423
LR  - 20181201
IS  - 1735-1502 (Print)
IS  - 1735-1502 (Linking)
VI  - 9
IP  - 3
DP  - 2010 Sep
TI  - The prevalence of celiac autoantibodies in hepatitis patients.
PG  - 157-62
LID - 09.03/ijaai.157162 [doi]
AB  - Celiac disease has been associated with other autoimmune disorders such as
      autoimmune hepatitis, moreover it is known that T cell mediated immune response
      to dietary gluten and released cytokines are important for the entheropathy seen 
      in celiac disease. We investigated celiac autoantibodies in patients with
      autoimmune hepatitis (AIH), and chronic hepatitis B (CHB).Sera from 84 patients
      with Autoimmune Hepatitis (AIH) type 1 and 88 patients with Chronic Hepatitis B
      (CHB) were tested for Immunoglobulin A and G antibodies to Gliadin,
      Immunoglobulin A antibodies to tissue transglutaminase using enzyme immunoassay, 
      and Immunoglobulin A anti-endomysial antibodies by both indirect
      immunofluorescence, and enzyme immunoassay. The patients positive for
      anti-endomysial antibodies and/or anti tissue transglutaminase antibodies were
      considered for deuodenal biopsy. The study was approved by Research Center for
      Gastroenterology and Liver Disease Ethics Committee and all patients gave their
      written informed consent to participate.Immunoglobulin A anti-endomysial and
      Immunoglobulin A anti-gliadin antibodies were positive in two out of 84 patients 
      with AIH. Moreover, Immunoglobulin A anti-gliadin antibodies were positive in
      another patient who was also positive for anti tissue transglutaminase
      antibodies. Tissue transglutaminase antibodies were positive in eight (9.1%) of
      88 patients with CHB, two of which were also positive for anti-endomysial
      antibodies. One of the patients with CHB was only positive for anti-endomysial
      antibodies.Compared with the general population, the prevalence of celiac
      autoantibodies in CHB and AIH patients is relatively high, and it is noteworthy
      that most positive patients were asymptomatic for celiac disease. We suggest
      screening for celiac disease before and during treatment in patients with viral
      and autoimmune hepatitis.
FAU - Sima, Hamidreza
AU  - Sima H
AD  - Research Institute for Gasteroenterology and Liver Disease, Shahid Beheshti
      University of Medical Sciences, Tehran, Iran. a_hekmat2000@yahoo.com.
FAU - Hekmatdoost, Azita
AU  - Hekmatdoost A
FAU - Ghaziani, Tahereh
AU  - Ghaziani T
FAU - Alavian, Seyed Moayyed
AU  - Alavian SM
FAU - Mashayekh, Ameneh
AU  - Mashayekh A
FAU - Zali, Mohammad Reza
AU  - Zali MR
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Allergy Asthma Immunol
JT  - Iranian journal of allergy, asthma, and immunology
JID - 101146178
RN  - 0 (Autoantibodies)
RN  - 0 (Immunoglobulin A)
RN  - 9007-90-3 (Gliadin)
SB  - IM
MH  - *Autoantibodies
MH  - Celiac Disease
MH  - *Gliadin
MH  - Hepatitis
MH  - Humans
MH  - Immunoglobulin A/immunology
MH  - Prevalence
EDAT- 2010/10/19 06:00
MHDA- 2016/04/24 06:00
CRDT- 2010/10/19 06:00
PHST- 2010/10/19 06:00 [entrez]
PHST- 2010/10/19 06:00 [pubmed]
PHST- 2016/04/24 06:00 [medline]
AID - 0903157162 [pii]
AID - 09.03/ijaai.157162 [doi]
PST - ppublish
SO  - Iran J Allergy Asthma Immunol. 2010 Sep;9(3):157-62. doi: 09.03/ijaai.157162.


PMID- 20952736
OWN - NLM
STAT- MEDLINE
DCOM- 20110131
LR  - 20101018
IS  - 1791-7549 (Electronic)
IS  - 0258-851X (Linking)
VI  - 24
IP  - 5
DP  - 2010 Sep-Oct
TI  - Diffuse alveolar damage due to inappropriate strategy of mechanical ventilation
      in an experimental porcine model.
PG  - 699-704
AB  - BACKGROUND: The aim of the study was to determine how tidal volumes may affect
      the lung and haemodynamics during mechanical ventilation. MATERIALS AND METHODS: 
      With the approval of the Ethics Committee, the study included a total of 24
      healthy piglets, average weight 30 kg (range 28-33 kg). The animals were
      ventilated for 90 minutes under general anaesthesia with two different tidal
      volume strategies and allocated into three groups. Group A, animals were healthy 
      controls, Group B, animals comprised 8 piglets with an abdominal aortic aneurysm 
      and ventilated with a low tidal volume strategy (VT(exp) 7 ml/kg). Group C
      comprised 8 animals seven days after kidney transplantation, ventilated with a
      high tidal volume strategy (VT(exp) 12 ml/kg). Changes in lung mechanics and
      hemodynamics were assessed at 30th and 90th minutes. Lung tissue samples were
      examined histologically. RESULTS: Protective ventilation in Group A and B did not
      confer any haemodynamic and lung mechanic differences. Significant differences
      were only found in Group C at 90 minutes for increased preload of both heart
      ventricles (CVP; t-test 4.07, p<0.01 and PAoP; t-test 8.43, p<0.01), pulmonary
      vascular resistance (t-test 3.11, p<0.05), and decreased expiratory tidal volume 
      (t-test 6.07, p<0.01), dynamic lung compliance (t-test 3.83, p<0.01) and cardiac 
      output (t-test 2.07, p<0.01). Diffuse alveolar damage was detected
      histologically. CONCLUSION: Mechanical ventilation at high tidal volumes reaching
      12 ml/kg caused functional changes in the lungs, diffuse alveolar damage and
      reduction of cardiac output within 90 minutes.
FAU - Kobr, J
AU  - Kobr J
AD  - Department of Paediatrics, Faculty Hospital in Pilsen, Alej Svobody 80, 304 60
      Plzen, Czech Republic. kobr@fnplzen.cz/jiri-kobr@lfp.cuni.cz
FAU - Kuntscher, V
AU  - Kuntscher V
FAU - Molacek, J
AU  - Molacek J
FAU - Hes, O
AU  - Hes O
FAU - Pizingerova, K
AU  - Pizingerova K
FAU - Kocova, J
AU  - Kocova J
FAU - Topolcan, O
AU  - Topolcan O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Greece
TA  - In Vivo
JT  - In vivo (Athens, Greece)
JID - 8806809
SB  - IM
MH  - Animals
MH  - Aortic Aneurysm, Abdominal/therapy
MH  - Cardiac Output
MH  - Disease Models, Animal
MH  - Female
MH  - Kidney Transplantation
MH  - Lung Compliance
MH  - Lung Diseases/*pathology/therapy
MH  - Male
MH  - Mechanotransduction, Cellular
MH  - Pneumonia/therapy
MH  - Pulmonary Alveoli/*injuries/*pathology
MH  - Pulmonary Circulation
MH  - Respiration, Artificial/*adverse effects/methods
MH  - Swine
MH  - *Tidal Volume
EDAT- 2010/10/19 06:00
MHDA- 2011/02/01 06:00
CRDT- 2010/10/19 06:00
PHST- 2010/10/19 06:00 [entrez]
PHST- 2010/10/19 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
AID - 24/5/699 [pii]
PST - ppublish
SO  - In Vivo. 2010 Sep-Oct;24(5):699-704.


PMID- 20952493
OWN - NLM
STAT- MEDLINE
DCOM- 20110315
LR  - 20220318
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 12
DP  - 2010 Dec
TI  - Ethics in systematic reviews.
PG  - 771-4
LID - 10.1136/jme.2010.039941 [doi]
AB  - Since its introduction by the Nuremberg Code and the Declaration of Helsinki, the
      place held by ethics in biomedical research has been continuously increasing in
      importance. The past 30&emsp14;years have also seen exponential growth in the
      number of biomedical articles published. A systematic review of the literature is
      the scientific way of synthesising a plethora of information, by exhaustively
      searching out and objectively analysing the studies dealing with a given issue.
      However, the question of ethics in systematic reviews is rarely touched upon.
      This could lead to some drawbacks, as systematic reviews may contain studies with
      ethical insufficiencies, may be a possible way to publish unethical research and 
      may also be prone to conflict of interest. Finally, informed consent given for an
      original study is not necessarily still valid at the systematic review level.
      There is no doubt that routine ethical assessment in systematic reviews would
      help to improve the ethical and methodological quality of studies in general.
      However, ethical issues change so much with time and location, and are so broad
      in scope and in context that it appears illusory to search for a universal,
      internationally accepted standard for ethical assessment in systematic reviews.
      Some simple suggestions could nevertheless be drawn from the present reflection
      and are discussed in the paper.
FAU - Vergnes, Jean-Noel
AU  - Vergnes JN
AD  - Dental Faculty, Paul Sabatier University, Department of Epidemiology, Public
      Health, Prevention and Legislation, Toulouse University Hospital, Toulouse,
      France. vergnes.jn@chu-toulouse.fr
FAU - Marchal-Sixou, Christine
AU  - Marchal-Sixou C
FAU - Nabet, Cathy
AU  - Nabet C
FAU - Maret, Delphine
AU  - Maret D
FAU - Hamel, Olivier
AU  - Hamel O
LA  - eng
PT  - Journal Article
DEP - 20101015
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Biomedical Research/*ethics
MH  - *Ethics, Research
MH  - Humans
MH  - Informed Consent/ethics
MH  - *Review Literature as Topic
EDAT- 2010/10/19 06:00
MHDA- 2011/03/16 06:00
CRDT- 2010/10/19 06:00
PHST- 2010/10/19 06:00 [entrez]
PHST- 2010/10/19 06:00 [pubmed]
PHST- 2011/03/16 06:00 [medline]
AID - jme.2010.039941 [pii]
AID - 10.1136/jme.2010.039941 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Dec;36(12):771-4. doi: 10.1136/jme.2010.039941. Epub 2010 Oct 
      15.


PMID- 20951950
OWN - NLM
STAT- MEDLINE
DCOM- 20110301
LR  - 20101018
IS  - 1865-9217 (Print)
IS  - 1865-9217 (Linking)
VI  - 104
IP  - 6
DP  - 2010
TI  - [Process optimization in the hospital--more than a method from the "quality
      diminution--work ethic"].
PG  - 433-4
LID - 10.1016/j.zefq.2010.07.013 [doi]
FAU - Eberlein-Gonska, Maria
AU  - Eberlein-Gonska M
FAU - Michael Albrecht, Detlev
AU  - Michael Albrecht D
LA  - ger
PT  - Editorial
TT  - Prozessoptimierung im Krankenhaus - mehr als eine Methode aus der
      "QM-Werkzeugkiste"
DEP - 20100821
PL  - Netherlands
TA  - Z Evid Fortbild Qual Gesundhwes
JT  - Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen
JID - 101477604
SB  - IM
MH  - *Ethics, Professional
MH  - Germany
MH  - Hospitals/*standards
MH  - Humans
MH  - Quality Assurance, Health Care
EDAT- 2010/10/19 06:00
MHDA- 2011/03/02 06:00
CRDT- 2010/10/19 06:00
PHST- 2010/10/19 06:00 [entrez]
PHST- 2010/10/19 06:00 [pubmed]
PHST- 2011/03/02 06:00 [medline]
AID - S1865-9217(10)00195-9 [pii]
AID - 10.1016/j.zefq.2010.07.013 [doi]
PST - ppublish
SO  - Z Evid Fortbild Qual Gesundhwes. 2010;104(6):433-4. doi:
      10.1016/j.zefq.2010.07.013. Epub 2010 Aug 21.


PMID- 20951819
OWN - NLM
STAT- MEDLINE
DCOM- 20110913
LR  - 20110523
IS  - 1523-6536 (Electronic)
IS  - 1083-8791 (Linking)
VI  - 17
IP  - 6
DP  - 2011 Jun
TI  - Donor cell leukemia: a review.
PG  - 771-89
LID - 10.1016/j.bbmt.2010.10.010 [doi]
AB  - Relapse of acute leukemia following hematopoietic stem cell transplantation
      (HSCT) usually represents return of an original disease clone, having evaded
      eradication by pretransplant chemo-/radiotherapy, conditioning, or posttransplant
      graft-versus-leukemia (GVL) effect. Rarely, acute leukemia can develop de novo in
      engrafted cells of donor origin. Donor cell leukemia (DCL) was first recognized
      in 1971, but for many years, the paucity of reported cases suggested it to be a
      rare phenomenon. However, in recent years, an upsurge in reported cases (in
      parallel with advances in molecular chimerism monitoring) suggest that it may be 
      significantly more common than previously appreciated; emerging evidence suggests
      that DCL might represent up to 5% of all posttransplant leukemia "relapses."
      Recognition of DCL is important for several reasons. Donor-derivation of the
      leukemic clone has implications when selecting appropriate therapy, because
      seeking to enhance an allogeneic GVL effect would intuitively not have the same
      role as in standard recipient-derived relapses. There are also broader
      implications for donor selection and workup, particularly given the growing
      popularity of nonmyeloblative HSCT and corresponding rising age of the potential 
      donor pool. Identification of DCL raises potential concerns over future health of
      the donor, posing ethical dilemmas regarding responsibilities toward donor
      notification (particularly in the context of cord blood transplantation). The
      entity of DCL is also of research interest, because it might provide a unique
      human model for studying the mechanisms of leukemogenesis in vivo. This review
      presents and collates all reported cases of DCL, and discusses the various
      strategies, controversies, and pitfalls when investigating origin of
      posttransplant relapse. Putative etiologic factors and mechanisms are proposed,
      and attempts made to address the difficult ethical questions posed by discovery
      of donor-derived malignancy within a HSCT recipient.
CI  - Copyright (c) 2011 American Society for Blood and Marrow Transplantation.
      Published by Elsevier Inc. All rights reserved.
FAU - Wiseman, Daniel H
AU  - Wiseman DH
AD  - Haematology Department, Manchester Royal Infirmary, Manchester, United Kingdom.
      daniel.wiseman@cmft.nhs.uk
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20101015
PL  - United States
TA  - Biol Blood Marrow Transplant
JT  - Biology of blood and marrow transplantation : journal of the American Society for
      Blood and Marrow Transplantation
JID - 9600628
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Aged
MH  - *Bone Marrow Transplantation/adverse effects
MH  - Child
MH  - Chimerism
MH  - Female
MH  - *Hematopoietic Stem Cell Transplantation/adverse effects
MH  - Humans
MH  - *Leukemia/genetics/mortality/pathology/therapy
MH  - Male
MH  - Middle Aged
MH  - *Neoplasms, Second Primary/genetics/mortality/pathology
MH  - Recurrence
MH  - Survival Analysis
MH  - Tissue Donors
MH  - Transplantation Conditioning
MH  - Transplantation, Homologous
MH  - Young Adult
EDAT- 2010/10/19 06:00
MHDA- 2011/09/14 06:00
CRDT- 2010/10/19 06:00
PHST- 2010/09/20 00:00 [received]
PHST- 2010/10/08 00:00 [accepted]
PHST- 2010/10/19 06:00 [entrez]
PHST- 2010/10/19 06:00 [pubmed]
PHST- 2011/09/14 06:00 [medline]
AID - S1083-8791(10)00448-9 [pii]
AID - 10.1016/j.bbmt.2010.10.010 [doi]
PST - ppublish
SO  - Biol Blood Marrow Transplant. 2011 Jun;17(6):771-89. doi:
      10.1016/j.bbmt.2010.10.010. Epub 2010 Oct 15.


PMID- 20951448
OWN - NLM
STAT- MEDLINE
DCOM- 20110111
LR  - 20101124
IS  - 1873-1716 (Electronic)
IS  - 0167-5877 (Linking)
VI  - 97
IP  - 3-4
DP  - 2010 Dec 1
TI  - Reporting guidelines for primary research: Saying what you did.
PG  - 144-9
LID - 10.1016/j.prevetmed.2010.09.010 [doi]
AB  - Reporting guidelines aim to facilitate publication of a full and accurate
      description of research conducted. The motivations for a full and accurate
      description of research is to enable reproduction of the study, assessment of
      bias, extraction of data from the study, and to fulfill an ethical obligation to 
      maximize the utility of research findings. Many reporting guidelines exist and
      most are based on a specific study design such as randomized controlled trials
      (CONSORT statement) and observational studies (STROBE statement). The REFLECT
      statement focuses on randomized control trials in livestock and food safety
      studies. The REFLECT statement has increased emphasis on conveying information
      about animal housing, group level allocation and challenge studies. Guidelines
      can be used by authors, reviewers and editors to provide readers with a full and 
      accurate description of the work conducted.
CI  - Copyright (c) 2010 Elsevier B.V. All rights reserved.
FAU - O'Connor, Annette
AU  - O'Connor A
AD  - Department of Veterinary Diagnostic & Production Animal Medicine, College of
      Veterinary Medicine, Iowa State University, USA. oconnor@iastate.edu
LA  - eng
PT  - Journal Article
DEP - 20101015
PL  - Netherlands
TA  - Prev Vet Med
JT  - Preventive veterinary medicine
JID - 8217463
SB  - IM
MH  - Animal Welfare
MH  - Animals
MH  - Animals, Domestic
MH  - Clinical Trials as Topic/*standards
MH  - Consumer Product Safety
MH  - *Evidence-Based Medicine
MH  - *Guidelines as Topic
MH  - Humans
MH  - Randomized Controlled Trials as Topic/standards
MH  - Research/*standards
MH  - Veterinary Medicine/*standards
EDAT- 2010/10/19 06:00
MHDA- 2011/01/12 06:00
CRDT- 2010/10/19 06:00
PHST- 2010/10/19 06:00 [entrez]
PHST- 2010/10/19 06:00 [pubmed]
PHST- 2011/01/12 06:00 [medline]
AID - S0167-5877(10)00259-X [pii]
AID - 10.1016/j.prevetmed.2010.09.010 [doi]
PST - ppublish
SO  - Prev Vet Med. 2010 Dec 1;97(3-4):144-9. doi: 10.1016/j.prevetmed.2010.09.010.
      Epub 2010 Oct 15.


PMID- 20950140
OWN - NLM
STAT- MEDLINE
DCOM- 20111013
LR  - 20161125
IS  - 1464-5165 (Electronic)
IS  - 0963-8288 (Linking)
VI  - 33
IP  - 13-14
DP  - 2011
TI  - Social participation of relatives post-stroke: the role of rehabilitation and
      related ethical issues.
PG  - 1055-64
LID - 10.3109/09638288.2010.524272 [doi]
AB  - PURPOSE: (1) Describe the challenges facing relatives of persons with stroke in
      accomplishing their daily activities and social roles (participation). (2)
      Reflect on the role of rehabilitation for relatives and ethical issues that may
      emerge following the adoption of a family-centred approach. METHOD: Review of the
      scientific literature in Medline (1996 to July 2009), Embase (1996 to July 2009) 
      databases using keywords: stroke AND participation AND family OR spouse OR
      caregivers AND ethics AND burden. Selection criteria were as follows: study must 
      examine the participation of relatives post-stroke (or equivalent concept such as
      burden), rehabilitation interventions for relatives post-stroke or ethical issues
      related to being a relative of a person with stroke. Articles not written in
      English or French were excluded. RESULTS: The sample comprised 17 scientific
      articles. According to five studies, social participation of relatives is
      characterised by increased responsibilities and a reduction in interpersonal
      relationships and leisure. In rehabilitation, there is no consensus regarding
      what should be done for relatives; guidelines exist but are not applied in
      practice. Little has been formally reported regarding ethical issues likely to
      emerge for relatives. CONCLUSIONS: The main impact of stroke is on social roles
      of relatives such as responsibilities, interpersonal relationships and leisure.
      The role of rehabilitation and related ethical issues needs further examination.
FAU - Pellerin, Caroline
AU  - Pellerin C
AD  - Occupational Therapy Program, School of Rehabilitation, Universite de Montreal,
      Montreal, Canada.
FAU - Rochette, Annie
AU  - Rochette A
FAU - Racine, Eric
AU  - Racine E
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20101015
PL  - England
TA  - Disabil Rehabil
JT  - Disability and rehabilitation
JID - 9207179
SB  - IM
MH  - *Caregivers
MH  - *Cost of Illness
MH  - *Family Health
MH  - Humans
MH  - Professional-Family Relations/*ethics
MH  - Rehabilitation/ethics
MH  - Social Support
MH  - Spouses
MH  - *Stroke Rehabilitation
EDAT- 2010/10/19 06:00
MHDA- 2011/10/14 06:00
CRDT- 2010/10/19 06:00
PHST- 2010/10/19 06:00 [entrez]
PHST- 2010/10/19 06:00 [pubmed]
PHST- 2011/10/14 06:00 [medline]
AID - 10.3109/09638288.2010.524272 [doi]
PST - ppublish
SO  - Disabil Rehabil. 2011;33(13-14):1055-64. doi: 10.3109/09638288.2010.524272. Epub 
      2010 Oct 15.


PMID- 20950070
OWN - NLM
STAT- MEDLINE
DCOM- 20110127
LR  - 20101018
IS  - 1744-8379 (Electronic)
IS  - 1473-7167 (Linking)
VI  - 10
IP  - 5
DP  - 2010 Oct
TI  - Priority setting in healthcare: towards guidelines for the program budgeting and 
      marginal analysis framework.
PG  - 539-52
LID - 10.1586/erp.10.66 [doi]
AB  - Economists' approaches to priority setting focus on the principles of opportunity
      cost, marginal analysis and choice under scarcity. These approaches are based on 
      the premise that it is possible to design a rational priority setting system that
      will produce legitimate changes in resource allocation. However, beyond issuing
      guidance at the national level, economic approaches to priority setting have had 
      only a moderate impact in practice. In particular, local health service
      organizations - such as health authorities, health maintenance organizations,
      hospitals and healthcare trusts - have had difficulty implementing evidence from 
      economic appraisals. Yet, in the context of making decisions between competing
      claims on scarce health service resources, economic tools and thinking have much 
      to offer. The purpose of this article is to describe and discuss ten
      evidence-based guidelines for the successful design and implementation of a
      program budgeting and marginal analysis (PBMA) priority setting exercise. PBMA is
      a framework that explicitly recognizes the need to balance pragmatic and ethical 
      considerations with economic rationality when making resource allocation
      decisions. While the ten guidelines are drawn from the PBMA framework, they may
      be generalized across a range of economic approaches to priority setting.
FAU - Peacock, Stuart J
AU  - Peacock SJ
AD  - Canadian Centre for Applied Research in Cancer Control (ARCC), Vancouver, BC,
      Canada. speacock@bccrc.ca
FAU - Mitton, Craig
AU  - Mitton C
FAU - Ruta, Danny
AU  - Ruta D
FAU - Donaldson, Cam
AU  - Donaldson C
FAU - Bate, Angela
AU  - Bate A
FAU - Hedden, Lindsay
AU  - Hedden L
LA  - eng
GR  - 162964/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Expert Rev Pharmacoecon Outcomes Res
JT  - Expert review of pharmacoeconomics & outcomes research
JID - 101132257
SB  - IM
MH  - Budgets/ethics/*methods
MH  - Decision Making, Organizational
MH  - Delivery of Health Care/economics/ethics/organization & administration
MH  - Evidence-Based Medicine/economics/ethics
MH  - *Guidelines as Topic
MH  - Health Policy/economics
MH  - Health Priorities/economics/ethics/*organization & administration
MH  - Humans
EDAT- 2010/10/19 06:00
MHDA- 2011/01/29 06:00
CRDT- 2010/10/19 06:00
PHST- 2010/10/19 06:00 [entrez]
PHST- 2010/10/19 06:00 [pubmed]
PHST- 2011/01/29 06:00 [medline]
AID - 10.1586/erp.10.66 [doi]
PST - ppublish
SO  - Expert Rev Pharmacoecon Outcomes Res. 2010 Oct;10(5):539-52. doi:
      10.1586/erp.10.66.


PMID- 20949877
OWN - NLM
STAT- MEDLINE
DCOM- 20101102
LR  - 20150612
IS  - 0042-8450 (Print)
IS  - 0042-8450 (Linking)
VI  - 67
IP  - 9
DP  - 2010 Sep
TI  - Ethics and deontology in forensic medicine.
PG  - 774-6
FAU - Matejic, Suzana
AU  - Matejic S
AD  - University of Pristina, School of Medicine, Kosovska Mitrovica, Serbia.
      matejics@gmail.com
FAU - Otasevic, Vujadin
AU  - Otasevic V
LA  - eng
PT  - Journal Article
PL  - Serbia
TA  - Vojnosanit Pregl
JT  - Vojnosanitetski pregled
JID - 21530700R
SB  - IM
MH  - *Ethical Theory
MH  - *Ethics, Medical
MH  - Expert Testimony/ethics
MH  - Forensic Medicine/*ethics
MH  - Humans
EDAT- 2010/10/19 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/10/19 06:00
PHST- 2010/10/19 06:00 [entrez]
PHST- 2010/10/19 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
PST - ppublish
SO  - Vojnosanit Pregl. 2010 Sep;67(9):774-6.


PMID- 20949839
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20191111
IS  - 0745-5194 (Print)
IS  - 0745-5194 (Linking)
VI  - 24
IP  - 3
DP  - 2010 Sep
TI  - "A disease of frozen feelings": ethically working on emotional worlds in a
      Russian Orthodox Church drug rehabilitation program.
PG  - 326-43
AB  - In a Russian Orthodox Church drug rehabilitation program in St. Petersburg, drug 
      addiction was often described as a disease of frozen feelings. This image
      suggests that rehabilitation is a process of thawing emotional worlds and, thus, 
      allows the emotions to flow once again. In this article I argue that "frozen
      feelings" is better understood as the unsocial emotional worlds many drug users
      experience, and that rehabilitation in this church-run program particularly
      focuses on the cultivation of an emotional world that supports sociality. This is
      done, I argue, by means of ethically training rehabilitants to learn how to
      control and manage their emotional worlds, and in so doing, rehabilitants become 
      new moral persons better able to live in the social world.
FAU - Zigon, Jarrett
AU  - Zigon J
AD  - Department of Sociology and Anthropology, University of Amsterdam, Max Planck
      Institute for Social Anthropology.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Med Anthropol Q
JT  - Medical anthropology quarterly
JID - 8405037
SB  - IM
MH  - Eastern Orthodoxy/*psychology
MH  - *Emotions
MH  - HIV Infections/epidemiology/prevention & control/transmission
MH  - Humans
MH  - Russia/epidemiology
MH  - Social Adjustment
MH  - *Substance Abuse Treatment Centers/ethics/methods/organization & administration
MH  - Substance-Related Disorders/epidemiology/*psychology/*rehabilitation
EDAT- 2010/10/19 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/10/19 06:00
PHST- 2010/10/19 06:00 [entrez]
PHST- 2010/10/19 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - 10.1111/j.1548-1387.2010.01107.x [doi]
PST - ppublish
SO  - Med Anthropol Q. 2010 Sep;24(3):326-43. doi: 10.1111/j.1548-1387.2010.01107.x.


PMID- 20949598
OWN - NLM
STAT- MEDLINE
DCOM- 20110630
LR  - 20220317
IS  - 1520-6777 (Electronic)
IS  - 0733-2467 (Linking)
VI  - 30
IP  - 3
DP  - 2011 Mar
TI  - Sonographic transvaginal bladder wall thickness: does the measurement
      discriminate between urodynamic diagnoses?
PG  - 325-8
LID - 10.1002/nau.20997 [doi]
AB  - INTRODUCTION: Measurement of bladder wall thickness (BWT) using transvaginal
      ultrasound has previously been shown to discriminate between women with confirmed
      detrusor overactivity and those with urodynamic stress incontinence. Aim of the
      current study was to determine if vaginally measured BWT correlates with
      urodynamic diagnoses in a female population. PATIENTS AND METHODS: Between
      December 2008 and February 2010, adult female consecutive patients undergoing
      urogynaecologic investigation for lower urinary symptoms were approached to
      participate in this study. Ethical consent for the current study was obtained.
      Patients underwent multichannel urodynamics and transvaginal ultrasound measuring
      the bladder in three location with an emptied bladder. RESULTS: 123 patients were
      included in the study with a median age of 69 years (range 40-93), median parity 
      of 2 (range 0-3) and a median body mass index of 29.5 kg/m(2) (range 23-38).
      Urodynamic stress incontinence was diagnosed in 59 patients, DO in 40 and
      obstruction in 24 cases. Bladder wall thickness was significantly higher in DO
      patients and in obstruction than in urodynamic stress incontinence. Detrusor
      pressure at maximum flow rate (pdet/Q(max) ) correlated significantly with BWT.
      CONCLUSION: Bladder wall thickness shows a significantly positive correlation to 
      pdet/Q(max) and to urodynamic diagnoses of stress incontinence, DO and
      obstruction.
CI  - Copyright (c) 2010 Wiley-Liss, Inc.
FAU - Kuhn, Annette
AU  - Kuhn A
AD  - Urogynaecology, Department of Obstetrics and Gynaecology, University of Bern and 
      University Hospital, Bern, Switzerland. annette.kuhn@insel.ch
FAU - Genoud, Sophie
AU  - Genoud S
FAU - Robinson, Dudley
AU  - Robinson D
FAU - Herrmann, Gudrun
AU  - Herrmann G
FAU - Gunthert, Andreas
AU  - Gunthert A
FAU - Brandner, Sonja
AU  - Brandner S
FAU - Raio, Luigi
AU  - Raio L
LA  - eng
PT  - Journal Article
DEP - 20101014
PL  - United States
TA  - Neurourol Urodyn
JT  - Neurourology and urodynamics
JID - 8303326
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Switzerland
MH  - Ultrasonography
MH  - Urinary Bladder/*diagnostic imaging/physiopathology
MH  - Urinary Bladder, Overactive/*diagnostic imaging/physiopathology
MH  - Urinary Incontinence, Stress/*diagnostic imaging/physiopathology
MH  - *Urodynamics
EDAT- 2010/10/16 06:00
MHDA- 2011/07/01 06:00
CRDT- 2010/10/16 06:00
PHST- 2010/05/12 00:00 [received]
PHST- 2010/07/21 00:00 [accepted]
PHST- 2010/10/16 06:00 [entrez]
PHST- 2010/10/16 06:00 [pubmed]
PHST- 2011/07/01 06:00 [medline]
AID - 10.1002/nau.20997 [doi]
PST - ppublish
SO  - Neurourol Urodyn. 2011 Mar;30(3):325-8. doi: 10.1002/nau.20997. Epub 2010 Oct 14.


PMID- 20949250
OWN - NLM
STAT- MEDLINE
DCOM- 20110803
LR  - 20101015
IS  - 1972-6007 (Electronic)
IS  - 0009-9074 (Linking)
VI  - 161
IP  - 5
DP  - 2010
TI  - Role for the families in child involving research.
PG  - 485-6
AB  - In a clinical research which involves disabled children, family plays a
      fundamental role for the stipulation of consent - according to international
      ethical guidelines - as well as it has to be considered one of the main
      caregivers in this context. Therefore this fundamental role has to be recognized 
      when considering the development of pediatric research programs, in which the
      family should be involved. In fact, therapeutic alliance between families and
      researchers should be considered, not only as a fundamental basis for children
      health and well-being, but also as an important resource for better outcomes in
      terms of research, health care and efficacy.
FAU - Mele, V
AU  - Mele V
AD  - Institute of Bioethics, A. Gemelli School of Medicine, Universita Cattolica del
      Sacro Cuore, Rome, Italy. vmele@rm.unicatt.it
FAU - Giglio, F
AU  - Giglio F
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Clin Ter
JT  - La Clinica terapeutica
JID - 0372604
SB  - IM
MH  - *Biomedical Research
MH  - *Child
MH  - *Family
MH  - Humans
MH  - Role
MH  - Terminology as Topic
EDAT- 2010/10/16 06:00
MHDA- 2011/08/04 06:00
CRDT- 2010/10/16 06:00
PHST- 2010/10/16 06:00 [entrez]
PHST- 2010/10/16 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
PST - ppublish
SO  - Clin Ter. 2010;161(5):485-6.


PMID- 20949247
OWN - NLM
STAT- MEDLINE
DCOM- 20110803
LR  - 20101015
IS  - 1972-6007 (Electronic)
IS  - 0009-9074 (Linking)
VI  - 161
IP  - 5
DP  - 2010
TI  - Ethical approaches to triage in public health emergencies.
PG  - 471-4
AB  - General concepts and about medical disasters, public health and triage are
      outlined. Ethical values at stake are summarized. A special attention is given to
      conflicts between protection of individual interests (typical of clinical ethics)
      and collective interests (typical of public health and triage). Hippocratic
      ethics is compared to utilitarian ethics and to perspectives that emphasize the
      principle of justice. Three attitudes are suggested: protection of human dignity,
      precaution, solidarity. A personalistic perspective is suggested to deepen
      solidarity as a pillar both of clinical and public health ethics.
FAU - Petrini, C
AU  - Petrini C
AD  - Bioethics Unit, Office of the President, National Institute of Health (Istituto
      Superiore di Sanita), Rome, Italy. carlo.petrini@iss.it
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - Clin Ter
JT  - La Clinica terapeutica
JID - 0372604
SB  - IM
MH  - *Emergencies
MH  - Humans
MH  - Public Health/*ethics
MH  - Triage/*ethics
EDAT- 2010/10/16 06:00
MHDA- 2011/08/04 06:00
CRDT- 2010/10/16 06:00
PHST- 2010/10/16 06:00 [entrez]
PHST- 2010/10/16 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
PST - ppublish
SO  - Clin Ter. 2010;161(5):471-4.


PMID- 20949049
OWN - NLM
STAT- MEDLINE
DCOM- 20110307
LR  - 20211020
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 5
IP  - 10
DP  - 2010 Oct 8
TI  - Developing a simplified consent form for biobanking.
PG  - e13302
LID - 10.1371/journal.pone.0013302 [doi]
LID - e13302 [pii]
AB  - BACKGROUND: Consent forms have lengthened over time and become harder for
      participants to understand. We sought to demonstrate the feasibility of creating 
      a simplified consent form for biobanking that comprises the minimum information
      necessary to meet ethical and regulatory requirements. We then gathered
      preliminary data concerning its content from hypothetical biobank participants.
      METHODOLOGY/PRINCIPAL FINDINGS: We followed basic principles of plain-language
      writing and incorporated into a 2-page form (not including the signature page)
      those elements of information required by federal regulations and recommended by 
      best practice guidelines for biobanking. We then recruited diabetes patients from
      community-based practices and randomized half (n = 56) to read the 2-page form,
      first on paper and then a second time on a tablet computer. Participants were
      encouraged to use "More information" buttons on the electronic version whenever
      they had questions or desired further information. These buttons led to a series 
      of "Frequently Asked Questions" (FAQs) that contained additional detailed
      information. Participants were asked to identify specific sentences in the FAQs
      they thought would be important if they were considering taking part in a
      biorepository. On average, participants identified 7 FAQ sentences as important
      (mean 6.6, SD 14.7, range: 0-71). No one sentence was highlighted by a majority
      of participants; further, 34 (60.7%) participants did not highlight any FAQ
      sentences. CONCLUSIONS: Our preliminary findings suggest that our 2-page form
      contains the information that most prospective participants identify as
      important. Combining simplified forms with supplemental material for those
      participants who desire more information could help minimize consent form length 
      and complexity, allowing the most substantively material information to be better
      highlighted and enabling potential participants to read the form and ask
      questions more effectively.
FAU - Beskow, Laura M
AU  - Beskow LM
AD  - Center for Genome Ethics, Law and Policy, Duke Institute for Genome Sciences and 
      Policy, Duke University, Durham, North Carolina, United States of America.
      laura.beskow@duke.edu
FAU - Friedman, Joelle Y
AU  - Friedman JY
FAU - Hardy, N Chantelle
AU  - Hardy NC
FAU - Lin, Li
AU  - Lin L
FAU - Weinfurt, Kevin P
AU  - Weinfurt KP
LA  - eng
GR  - UL1 RR024128/RR/NCRR NIH HHS/United States
GR  - 1UL1RR024128/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20101008
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Confidentiality
MH  - Cost-Benefit Analysis
MH  - Diabetes Mellitus/physiopathology
MH  - Humans
MH  - *Informed Consent
MH  - *Tissue Banks
PMC - PMC2951917
EDAT- 2010/10/16 06:00
MHDA- 2011/03/08 06:00
CRDT- 2010/10/16 06:00
PHST- 2010/04/09 00:00 [received]
PHST- 2010/09/01 00:00 [accepted]
PHST- 2010/10/16 06:00 [entrez]
PHST- 2010/10/16 06:00 [pubmed]
PHST- 2011/03/08 06:00 [medline]
AID - 10.1371/journal.pone.0013302 [doi]
PST - epublish
SO  - PLoS One. 2010 Oct 8;5(10):e13302. doi: 10.1371/journal.pone.0013302.


PMID- 20947698
OWN - NLM
STAT- MEDLINE
DCOM- 20110314
LR  - 20181201
IS  - 1573-286X (Electronic)
IS  - 1079-0632 (Linking)
VI  - 22
IP  - 4
DP  - 2010 Dec
TI  - Therapist awareness and responsibility in working with sexual offenders.
PG  - 374-86
LID - 10.1177/1079063210382047 [doi]
AB  - The article aims to address the ethical implications of therapist reactions to
      sexual offender treatment and, in doing so, increase awareness and understanding 
      of the interaction between the clinician and the challenges of working with
      sexual offenders. The effects of providing psychological services in general, and
      to sexual offenders specifically, are reviewed, including the impact on services 
      provided. Practice implications are also discussed as the authors consider the
      negative effects (e.g., burnout) that therapists experience due to treatment
      quality and the ethical issues and responsibilities surrounding clinical
      reactions. Finally, the authors summarize research on self-care and practice
      recommendations for effectively and ethically working with sexual offenders.
FAU - Moulden, Heather M
AU  - Moulden HM
AD  - Forensic Service, St. Joseph's Healthcare Hamilton & Department of Psychiatry and
      Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada.
      hmoulden@stjoes.ca
FAU - Firestone, Philip
AU  - Firestone P
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20101014
PL  - United States
TA  - Sex Abuse
JT  - Sexual abuse : a journal of research and treatment
JID - 9506704
SB  - IM
MH  - Attitude of Health Personnel
MH  - Burnout, Professional/psychology
MH  - Cognitive Behavioral Therapy/methods
MH  - Counseling/*methods
MH  - Criminals/psychology
MH  - Forensic Psychiatry/*methods
MH  - Humans
MH  - Practice Patterns, Physicians'/*ethics
MH  - Professional Role
MH  - Professional-Patient Relations/*ethics
MH  - Secondary Prevention
MH  - Sex Offenses/*prevention & control
EDAT- 2010/10/16 06:00
MHDA- 2011/03/15 06:00
CRDT- 2010/10/16 06:00
PHST- 2010/10/16 06:00 [entrez]
PHST- 2010/10/16 06:00 [pubmed]
PHST- 2011/03/15 06:00 [medline]
AID - 1079063210382047 [pii]
AID - 10.1177/1079063210382047 [doi]
PST - ppublish
SO  - Sex Abuse. 2010 Dec;22(4):374-86. doi: 10.1177/1079063210382047. Epub 2010 Oct
      14.


PMID- 20947263
OWN - NLM
STAT- MEDLINE
DCOM- 20110727
LR  - 20220311
IS  - 1879-355X (Electronic)
IS  - 0360-3016 (Linking)
VI  - 80
IP  - 3
DP  - 2011 Jul 1
TI  - Interfraction liver shape variability and impact on GTV position during liver
      stereotactic radiotherapy using abdominal compression.
PG  - 938-46
LID - 10.1016/j.ijrobp.2010.08.003 [doi]
AB  - PURPOSE: For patients receiving liver stereotactic body radiotherapy (SBRT),
      abdominal compression can reduce organ motion, and daily image guidance can
      reduce setup error. The reproducibility of liver shape under compression may
      impact treatment delivery accuracy. The purpose of this study was to measure the 
      interfractional variability in liver shape under compression, after best-fit
      rigid liver-to-liver registration from kilovoltage (kV) cone beam computed
      tomography (CBCT) scans to planning computed tomography (CT) scans and its impact
      on gross tumor volume (GTV) position. METHODS AND MATERIALS: Evaluable patients
      were treated in a Research Ethics Board-approved SBRT six-fraction study with
      abdominal compression. Kilovoltage CBCT scans were acquired before treatment and 
      reconstructed as respiratory sorted CBCT scans offline. Manual rigid
      liver-to-liver registrations were performed from exhale-phase CBCT scans to
      exhale planning CT scans. Each CBCT liver was contoured, exported, and compared
      with the planning CT scan for spatial differences, by use of in house-developed
      finite-element model-based deformable registration (MORFEUS). RESULTS: We
      evaluated 83 CBCT scans from 16 patients with 30 GTVs. The mean volume of liver
      that deformed by greater than 3 mm was 21.7%. Excluding 1 outlier, the maximum
      volume that deformed by greater than 3 mm was 36.3% in a single patient. Over all
      patients, the absolute maximum deformations in the left-right (LR),
      anterior-posterior (AP), and superior-inferior directions were 10.5 mm (SD, 2.2),
      12.9 mm (SD, 3.6), and 5.6 mm (SD, 2.7), respectively. The absolute mean
      predicted impact of liver volume displacements on GTV by use of center of mass
      displacements was 0.09 mm (SD, 0.13), 0.13 mm (SD, 0.18), and 0.08 mm (SD, 0.07) 
      in the left-right, anterior-posterior, and superior-inferior directions,
      respectively. CONCLUSIONS: Interfraction liver deformations in patients
      undergoing SBRT under abdominal compression after rigid liver-to-liver
      registrations on respiratory sorted CBCT scans were small in most patients (<5
      mm).
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Eccles, Cynthia L
AU  - Eccles CL
AD  - Princess Margaret Hospital, and University of Toronto, Toronto, Ontario, Canada. 
      cynthia.eccles@rob.ox.ac.uk
FAU - Dawson, Laura A
AU  - Dawson LA
FAU - Moseley, Joanne L
AU  - Moseley JL
FAU - Brock, Kristy K
AU  - Brock KK
LA  - eng
GR  - R01 CA124714/CA/NCI NIH HHS/United States
GR  - R01 CA124714-01A2/CA/NCI NIH HHS/United States
GR  - 5R01CA124714/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20101013
PL  - United States
TA  - Int J Radiat Oncol Biol Phys
JT  - International journal of radiation oncology, biology, physics
JID - 7603616
SB  - IM
MH  - Abdomen
MH  - Aged
MH  - Aged, 80 and over
MH  - Cone-Beam Computed Tomography
MH  - Female
MH  - Finite Element Analysis
MH  - Humans
MH  - Immobilization/*methods
MH  - Liver/anatomy & histology/*diagnostic imaging
MH  - Liver Neoplasms/*diagnostic imaging/pathology/*surgery
MH  - Male
MH  - Middle Aged
MH  - Movement
MH  - Organ Size
MH  - Pressure
MH  - Radiosurgery/*methods
MH  - Reproducibility of Results
MH  - Respiration
MH  - *Tumor Burden
PMC - PMC3037422
MID - NIHMS245896
EDAT- 2010/10/16 06:00
MHDA- 2011/07/28 06:00
CRDT- 2010/10/16 06:00
PHST- 2009/07/02 00:00 [received]
PHST- 2010/07/18 00:00 [revised]
PHST- 2010/08/03 00:00 [accepted]
PHST- 2010/10/16 06:00 [entrez]
PHST- 2010/10/16 06:00 [pubmed]
PHST- 2011/07/28 06:00 [medline]
AID - S0360-3016(10)03049-X [pii]
AID - 10.1016/j.ijrobp.2010.08.003 [doi]
PST - ppublish
SO  - Int J Radiat Oncol Biol Phys. 2011 Jul 1;80(3):938-46. doi:
      10.1016/j.ijrobp.2010.08.003. Epub 2010 Oct 13.


PMID- 20946568
OWN - NLM
STAT- MEDLINE
DCOM- 20110519
LR  - 20110114
IS  - 1365-2648 (Electronic)
IS  - 0309-2402 (Linking)
VI  - 67
IP  - 2
DP  - 2011 Feb
TI  - Care-based ethical reasoning among first-year nursing and social services
      students.
PG  - 418-27
LID - 10.1111/j.1365-2648.2010.05461.x [doi]
AB  - AIM: This paper is a report of a study conducted to describe nursing and social
      services students' ethical reasoning at the start of their studies. BACKGROUND:
      Gilligan argued that there are two modes of moral reasoning - the ethic of
      justice, focusing on individuals' rights, and the ethic of care, focusing on
      responsibilities in relationships. Recent research has established the ethic of
      care as a developmental phenomenon. It has been widely argued that the ethic of
      care is crucial for nursing, but there has been little international research in 
      this area. METHOD: Participants were first-year nursing and social services
      students in Finland (N =112). Their care-based moral reasoning was measured using
      the Ethic of Care Interview, and their ethical reasoning on an abortion-related
      dilemma was analysed by content analysis. Expressed ethical codes and principles 
      were calculated according to levels. The data were collected over a 5-month
      period in 2007-2008. FINDINGS: Students' level of care reasoning was varied.
      Their current level of care reasoning was reflected in their responses to the
      ethical dilemma. Ethical reasoning at each level and its specific premises
      constituted a distinct entity. Use of the principle of self-determination was
      positively related to levels of care development. Care-based moral reasoning
      constitutes the bedrock for ethical reasoning among these novice students.
      CONCLUSION: Educators should be sensitive to the variation in students' current
      developmental levels in care reasoning. Reflective discussion on real-life
      ethical conflicts should be an explicit part of education and clinical practice
      in caring professions.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Juujarvi, Soile
AU  - Juujarvi S
AD  - Laurea University of Applied Sciences, Espoo, Finland. soile.juujarvi@laurea.fi
FAU - Pesso, Kaija
AU  - Pesso K
FAU - Myyry, Liisa
AU  - Myyry L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101015
PL  - England
TA  - J Adv Nurs
JT  - Journal of advanced nursing
JID - 7609811
SB  - IM
MH  - Abortion, Induced/ethics
MH  - Adult
MH  - Counseling/ethics
MH  - Decision Making/ethics
MH  - Female
MH  - Finland
MH  - Humans
MH  - *Interpersonal Relations
MH  - Male
MH  - Middle Aged
MH  - Models, Psychological
MH  - *Moral Development
MH  - Nursing Education Research
MH  - Pregnancy
MH  - Social Work/*education
MH  - Students/psychology
MH  - Students, Nursing/*psychology
MH  - *Thinking
MH  - Young Adult
EDAT- 2010/10/16 06:00
MHDA- 2011/05/20 06:00
CRDT- 2010/10/16 06:00
PHST- 2010/10/16 06:00 [entrez]
PHST- 2010/10/16 06:00 [pubmed]
PHST- 2011/05/20 06:00 [medline]
AID - 10.1111/j.1365-2648.2010.05461.x [doi]
PST - ppublish
SO  - J Adv Nurs. 2011 Feb;67(2):418-27. doi: 10.1111/j.1365-2648.2010.05461.x. Epub
      2010 Oct 15.


PMID- 20946469
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20220316
IS  - 1399-0012 (Electronic)
IS  - 0902-0063 (Linking)
VI  - 25
IP  - 3
DP  - 2011 May-Jun
TI  - Kidney transplantation in the morbidly obese: complicated but still better than
      dialysis.
PG  - 401-5
LID - 10.1111/j.1399-0012.2010.01328.x [doi]
AB  - Obese patients are denied renal transplantation in many centers. We report
      results regarding obesity from a new transplant program (1999 through 2007). Six 
      hundred and forty-two patients were transplanted: 439 patients with BMI < 30
      (Group 1), 109 patients with BMI 30.1-34.9 (Group 2), and 89 patients with BMI > 
      35 (Group 3). Follow-up was at least one yr. Medical and surgical management was 
      performed by the same team throughout the study period. There were no demographic
      differences between groups except for increased diabetes in Groups 2 and 3.
      Actuarial graft and patient survivals were not statistically different between
      groups. Group 3 patients had numerical trends toward more delayed graft function 
      and lower graft survivals but these did not reach statistical significance.
      Biopsy-proven rejections did not differ between groups. Wound infections were
      statistically significant in Groups 2 and 3 compared to Group 1 (p < 0.01).
      Despite increased wound infection rates with increased BMI, transplanting
      patients with morbid obesity results in better survival for individual patients
      than dialysis. Thus, there is no a priori ethical reason for treating obese ESRD 
      patients differently from those with other comorbidities.
CI  - (c) 2010 John Wiley & Sons A/S.
FAU - Bennett, William M
AU  - Bennett WM
AD  - Legacy Good Samaritan Hospital, Portland, OR, USA. bennettw@lhs.org
FAU - McEvoy, Kevin M
AU  - McEvoy KM
FAU - Henell, Karen R
AU  - Henell KR
FAU - Pidikiti, Sudha
AU  - Pidikiti S
FAU - Douzdjian, Viken
AU  - Douzdjian V
FAU - Batiuk, Thomas
AU  - Batiuk T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20101014
PL  - Denmark
TA  - Clin Transplant
JT  - Clinical transplantation
JID - 8710240
SB  - IM
MH  - Body Mass Index
MH  - Female
MH  - Follow-Up Studies
MH  - Glomerular Filtration Rate
MH  - Graft Rejection/etiology/*mortality
MH  - Humans
MH  - Kidney Failure, Chronic/*surgery
MH  - Kidney Function Tests
MH  - Kidney Transplantation/*adverse effects
MH  - Male
MH  - Middle Aged
MH  - Obesity, Morbid/*complications/*surgery
MH  - Prognosis
MH  - Renal Dialysis/*adverse effects
MH  - Risk Factors
MH  - Survival Rate
EDAT- 2010/10/16 06:00
MHDA- 2011/10/01 06:00
CRDT- 2010/10/16 06:00
PHST- 2010/10/16 06:00 [entrez]
PHST- 2010/10/16 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - 10.1111/j.1399-0012.2010.01328.x [doi]
PST - ppublish
SO  - Clin Transplant. 2011 May-Jun;25(3):401-5. doi: 10.1111/j.1399-0012.2010.01328.x.
      Epub 2010 Oct 14.


PMID- 20945733
OWN - NLM
STAT- MEDLINE
DCOM- 20101102
LR  - 20101223
IS  - 0040-4284 (Print)
IS  - 0040-4284 (Linking)
VI  - 127
IP  - 8
DP  - 2010 Aug
TI  - Conflicts of interest in research: is clinical decision-making compromised? An
      opinion paper.
PG  - 735-41
AB  - Lack of transparency in funded research can compromise clinical decision-making
      in an evidence-based practice. Transparency can be defined as full disclosure of 
      all financial assistance and support to authors and investigators. There is a
      perception that ethical principles are eroding and that research data can be
      biased due to conflicts of interest. These research outcomes biased or not, are
      used for clinical decision-making in the evidence-based practice. One suggested
      solution to this common ethical dilemma is to continue the dialogue on
      transparency in research and to create oversight bodies which include
      representatives from business and industry, private practice, academia, and
      research. There is increasing evidence of the need for more ethics education at
      all levels.
FAU - Adibi, Shawn
AU  - Adibi S
AD  - University of Texas Health Science Center at Houston Dental Branch, USA.
FAU - Bebermeyer, Richard D
AU  - Bebermeyer RD
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Tex Dent J
JT  - Texas dental journal
JID - 2984821R
EIN - Tex Dent J. 2010 Oct;127(10):1032. Abidi, Shawn [corrected to Adibi, Shawn]
MH  - Commerce
MH  - *Conflict of Interest
MH  - *Decision Making
MH  - Dental Research/ethics
MH  - Disclosure/ethics
MH  - Ethics, Business
MH  - Ethics, Dental/education
MH  - *Ethics, Research
MH  - Evidence-Based Dentistry/ethics
MH  - Humans
MH  - Industry
MH  - Interprofessional Relations
MH  - Public Policy
MH  - Publishing/ethics
MH  - Research Support as Topic/ethics
MH  - Researcher-Subject Relations/ethics
MH  - Risk Assessment
EDAT- 2010/10/16 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/10/16 06:00
PHST- 2010/10/16 06:00 [entrez]
PHST- 2010/10/16 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
PST - ppublish
SO  - Tex Dent J. 2010 Aug;127(8):735-41.


PMID- 20945476
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110204
LR  - 20150220
IS  - 1553-5606 (Electronic)
IS  - 1553-5592 (Linking)
VI  - 5
IP  - 8
DP  - 2010 Oct
TI  - Postcards from our students--reflections on professionalism and ethics.
PG  - 496-9
LID - 10.1002/jhm.858 [doi]
FAU - Neely, David
AU  - Neely D
AD  - Department of Medicine, Northwestern University Feinberg School of Medicine,
      Chicago, Illinois, USA. dneely@nmh.org
FAU - Szmuilowicz, Eytan
AU  - Szmuilowicz E
FAU - Neely, Kathy
AU  - Neely K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Hosp Med
JT  - Journal of hospital medicine
JID - 101271025
RPF - J Hosp Med. 2010 May-Jun;5(5):E10-3. PMID: 20533587
EDAT- 2010/10/15 06:00
MHDA- 2010/10/15 06:01
CRDT- 2010/10/15 06:00
PHST- 2010/10/15 06:00 [entrez]
PHST- 2010/10/15 06:00 [pubmed]
PHST- 2010/10/15 06:01 [medline]
AID - 10.1002/jhm.858 [doi]
PST - ppublish
SO  - J Hosp Med. 2010 Oct;5(8):496-9. doi: 10.1002/jhm.858.


PMID- 20945266
OWN - NLM
STAT- MEDLINE
DCOM- 20101109
LR  - 20191210
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 10
DP  - 2010 Oct
TI  - Emerging neurotechnologies for lie-detection: promises and perils.
PG  - 40-8
LID - 10.1080/15265161.2010.519238 [doi]
AB  - Detection of deception and confirmation of truth telling with conventional
      polygraphy raised a host of technical and ethical issues. Recently, newer methods
      of recording electromagnetic signals from the brain show promise in permitting
      the detection of deception or truth telling. Some are even being promoted as more
      accurate than conventional polygraphy. While the new technologies raise issues of
      personal privacy, acceptable forensic application, and other social issues, the
      focus of this paper is the technical limitations of the developing technology.
      Those limitations include the measurement validity of the new technologies, which
      remains largely unknown. Another set of questions pertains to the psychological
      paradigms used to model or constrain the target behavior. Finally, there is
      little standardization in the field, and the vulnerability of the techniques to
      countermeasures is unknown. Premature application of these technologies outside
      of research settings should be resisted, and the social conversation about the
      appropriate parameters of its civil, forensic, and security use should begin.
FAU - Wolpe, Paul Root
AU  - Wolpe PR
AD  - University of Pennsylvania, USA.
FAU - Foster, Kenneth R
AU  - Foster KR
FAU - Langleben, Daniel D
AU  - Langleben DD
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CIN - Am J Bioeth. 2010 Oct;10(10):49-50. PMID: 20945267
MH  - *Biotechnology/ethics/instrumentation/methods/trends
MH  - Brain/physiology
MH  - Coercion
MH  - *Confidentiality
MH  - Confounding Factors, Epidemiologic
MH  - Electromagnetic Fields
MH  - Freedom
MH  - Humans
MH  - *Lie Detection
MH  - Magnetic Resonance Imaging/ethics
MH  - *Neurosciences/ethics/instrumentation/methods/trends
MH  - *Observer Variation
MH  - Personality
MH  - Predictive Value of Tests
MH  - *Privacy
MH  - Reproducibility of Results
MH  - Research Design
MH  - Sensitivity and Specificity
MH  - United States
EDAT- 2010/10/15 06:00
MHDA- 2010/11/10 06:00
CRDT- 2010/10/15 06:00
PHST- 2010/10/15 06:00 [entrez]
PHST- 2010/10/15 06:00 [pubmed]
PHST- 2010/11/10 06:00 [medline]
AID - 927985868 [pii]
AID - 10.1080/15265161.2010.519238 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Oct;10(10):40-8. doi: 10.1080/15265161.2010.519238.


PMID- 20945265
OWN - NLM
STAT- MEDLINE
DCOM- 20101109
LR  - 20101014
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 10
DP  - 2010 Oct
TI  - "Rethinking research ethics," again: Casuistry, phronesis, and the continuing
      challenges of human research.
PG  - 37-9
LID - 10.1080/15265161.2010.526444 [doi]
FAU - Koski, Greg
AU  - Koski G
AD  - James Mongan Institute for Health Policy, Department of Anesthesia, Critical Care
      and Pain Medicine, Massachusetts General Hospital, Harvard Medical School,
      Boston, MA 02114, USA. gkoski@partners.org
LA  - eng
PT  - Comment
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2010 Oct;10(10):19-36. PMID: 20945264
MH  - Casuistry
MH  - *Codes of Ethics/history
MH  - *Ethics, Research/history
MH  - Germany
MH  - History, 19th Century
MH  - History, 20th Century
MH  - Human Experimentation/*ethics/legislation & jurisprudence
MH  - Humans
MH  - National Socialism
MH  - Patient Participation
MH  - Research Subjects/legislation & jurisprudence/supply & distribution
MH  - United States
EDAT- 2010/10/15 06:00
MHDA- 2010/11/10 06:00
CRDT- 2010/10/15 06:00
PHST- 2010/10/15 06:00 [entrez]
PHST- 2010/10/15 06:00 [pubmed]
PHST- 2010/11/10 06:00 [medline]
AID - 927986017 [pii]
AID - 10.1080/15265161.2010.526444 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Oct;10(10):37-9. doi: 10.1080/15265161.2010.526444.


PMID- 20945264
OWN - NLM
STAT- MEDLINE
DCOM- 20101109
LR  - 20220331
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 10
DP  - 2010 Oct
TI  - Rethinking research ethics.
PG  - 19-36
LID - 10.1080/15265161.2010.519233 [doi]
AB  - Contemporary research ethics policies started with reflection on the atrocities
      perpetrated upon concentration camp inmates by Nazi doctors. Apparently, as a
      consequence of that experience, the policies that now guide human subject
      research focus on the protection of human subjects by making informed consent the
      centerpiece of regulatory attention. I take the choice of context for policy
      design, the initial prioritization of informed consent, and several associated
      conceptual missteps, to have set research ethics off in the wrong direction. The 
      aim of this paper is to sort out these confusions and their implications and to
      offer instead a straightforward framework for considering the ethical conduct of 
      human subject research. In the course of this discussion I clarify different
      senses of autonomy that have been confounded and present more intelligible
      justifications for informed consent. I also take issue with several of the now
      accepted dogmas that govern research ethics. These include: the primacy of
      informed consent, the protection of the vulnerable, the substitution of
      beneficence for research's social purpose, and the introduction of an untenable
      distinction between innovation and research.
FAU - Rhodes, Rosamond
AU  - Rhodes R
AD  - Mount Sinai School of Medicine, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CIN - Am J Bioeth. 2010 Oct;10(10):37-9. PMID: 20945265
MH  - Adolescent
MH  - Beneficence
MH  - Child
MH  - Choice Behavior/ethics
MH  - Coercion
MH  - Decision Making/ethics
MH  - Ethics Committees, Research
MH  - *Ethics, Research
MH  - Human Experimentation/*ethics/legislation & jurisprudence
MH  - Humans
MH  - *Informed Consent/ethics/legislation & jurisprudence
MH  - Mental Competency
MH  - Minors
MH  - National Socialism
MH  - Parental Consent
MH  - Patient Acceptance of Health Care
MH  - Patient Participation
MH  - *Personal Autonomy
MH  - Public Policy
MH  - Research Design
MH  - Research Subjects/legislation & jurisprudence
MH  - Trust
MH  - United States
MH  - United States Dept. of Health and Human Services
MH  - Vulnerable Populations
EDAT- 2010/10/15 06:00
MHDA- 2010/11/10 06:00
CRDT- 2010/10/15 06:00
PHST- 2010/10/15 06:00 [entrez]
PHST- 2010/10/15 06:00 [pubmed]
PHST- 2010/11/10 06:00 [medline]
AID - 927986387 [pii]
AID - 10.1080/15265161.2010.519233 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Oct;10(10):19-36. doi: 10.1080/15265161.2010.519233.


PMID- 20945262
OWN - NLM
STAT- MEDLINE
DCOM- 20101109
LR  - 20101014
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 10
DP  - 2010 Oct
TI  - All gifts large and small: toward an understanding of the ethics of
      pharmaceutical industry gift-giving.
PG  - 11-7
LID - 10.1080/15265161.2010.519226 [doi]
AB  - Much attention has been focused in recent years on the ethical acceptability of
      physicians receiving gifts from drug companies. Professional guidelines recognize
      industry gifts as a conflict of interest and establish thresholds prohibiting the
      exchange of large gifts while expressly allowing for the exchange of small gifts 
      such as pens, note pads, and coffee. Considerable evidence from the social
      sciences suggests that gifts of negligible value can influence the behavior of
      the recipient in ways the recipient does not always realize. Policies and
      guidelines that rely on arbitrary value limits for gift-giving or receipt should 
      be reevaluated.
FAU - Katz, Dana
AU  - Katz D
AD  - University of Pennsylvania, USA.
FAU - Caplan, Arthur L
AU  - Caplan AL
FAU - Merz, Jon F
AU  - Merz JF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CIN - Am J Bioeth. 2010 Oct;10(10):18. PMID: 20945263
MH  - American Medical Association
MH  - *Conflict of Interest/economics/legislation & jurisprudence
MH  - Cooperative Behavior
MH  - Drug Industry/*ethics
MH  - Gift Giving/*ethics
MH  - *Guidelines as Topic
MH  - Humans
MH  - Information Dissemination/*ethics
MH  - *Interpersonal Relations
MH  - Physicians/*ethics
MH  - Public Policy
MH  - *Social Values
MH  - United States
EDAT- 2010/10/15 06:00
MHDA- 2010/11/10 06:00
CRDT- 2010/10/15 06:00
PHST- 2010/10/15 06:00 [entrez]
PHST- 2010/10/15 06:00 [pubmed]
PHST- 2010/11/10 06:00 [medline]
AID - 927986288 [pii]
AID - 10.1080/15265161.2010.519226 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Oct;10(10):11-7. doi: 10.1080/15265161.2010.519226.


PMID- 20945260
OWN - NLM
STAT- MEDLINE
DCOM- 20101109
LR  - 20171116
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 10
DP  - 2010 Oct
TI  - An open letter to institutional review boards considering Northfield
      Laboratories' PolyHeme(R) trial.
PG  - 5-8
LID - 10.1080/15265161.2010.519230 [doi]
AB  - At the time of this writing, a widely publicized, waived-consent trial is
      underway. Sponsored by Northfield Laboratories, Inc. (Evanston, IL) the trial is 
      intended to evaluate the emergency use of PolyHeme(R), an oxygen-carrying
      resuscitative fluid that might prevent deaths from uncontrolled bleeding. The
      protocol allows patients in hemorrhagic shock to be randomized between
      PolyHeme(R) and saline in the field and, still without consent, randomized
      between PolyHeme(R) and blood after arrival at an emergency department. The
      Federal regulations that govern the waiver of consent restrict its applicability 
      to circumstances where proven, satisfactory treatments are unavailable. Blood-the
      standard treatment for hemorrhagic shock-is not available in ambulances but is
      available in hospitals. The authors argue that the in-hospital stage of the study
      fails to meet ethical and regulatory standards.
FAU - Kipnis, Ken
AU  - Kipnis K
AD  - University of Hawaii at Manoa, USA.
FAU - King, Nancy M P
AU  - King NM
FAU - Nelson, Robert M
AU  - Nelson RM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
RN  - 0 (Blood Substitutes)
RN  - 0 (Hemoglobins)
RN  - 0 (PolyHeme)
RN  - 451W47IQ8X (Sodium Chloride)
SB  - IM
CIN - Am J Bioeth. 2010 Oct;10(10):9-10. PMID: 20945261
MH  - Ambulances/ethics
MH  - Blood Coagulation
MH  - Blood Substitutes/*administration & dosage/adverse effects
MH  - Drug Industry/*ethics
MH  - Emergency Service, Hospital/*ethics
MH  - Emergency Treatment/*ethics/methods
MH  - *Ethics Committees, Research
MH  - Hemoglobins/*administration & dosage/adverse effects
MH  - Humans
MH  - *Informed Consent/ethics
MH  - Laboratories/ethics
MH  - Randomized Controlled Trials as Topic/*ethics/methods
MH  - Research Design/standards
MH  - Shock, Hemorrhagic/therapy
MH  - Sodium Chloride/administration & dosage
MH  - Transfusion Reaction
MH  - United States
EDAT- 2010/10/15 06:00
MHDA- 2010/11/10 06:00
CRDT- 2010/10/15 06:00
PHST- 2010/10/15 06:00 [entrez]
PHST- 2010/10/15 06:00 [pubmed]
PHST- 2010/11/10 06:00 [medline]
AID - 927985644 [pii]
AID - 10.1080/15265161.2010.519230 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Oct;10(10):5-8. doi: 10.1080/15265161.2010.519230.


PMID- 20944079
OWN - NLM
STAT- MEDLINE
DCOM- 20101214
LR  - 20211020
IS  - 1460-2105 (Electronic)
IS  - 0027-8874 (Linking)
VI  - 102
IP  - 22
DP  - 2010 Nov 17
TI  - Cancer pharmacogenomics and pharmacoepidemiology: setting a research agenda to
      accelerate translation.
PG  - 1698-705
LID - 10.1093/jnci/djq390 [doi]
AB  - Recent advances in genomic research have demonstrated a substantial role for
      genomic factors in predicting response to cancer therapies. Researchers in the
      fields of cancer pharmacogenomics and pharmacoepidemiology seek to understand why
      individuals respond differently to drug therapy, in terms of both adverse effects
      and treatment efficacy. To identify research priorities as well as the resources 
      and infrastructure needed to advance these fields, the National Cancer Institute 
      (NCI) sponsored a workshop titled "Cancer Pharmacogenomics: Setting a Research
      Agenda to Accelerate Translation" on July 21, 2009, in Bethesda, MD. In this
      commentary, we summarize and discuss five science-based recommendations and four 
      infrastructure-based recommendations that were identified as a result of
      discussions held during this workshop. Key recommendations include 1) supporting 
      the routine collection of germline and tumor biospecimens in NCI-sponsored
      clinical trials and in some observational and population-based studies; 2)
      incorporating pharmacogenomic markers into clinical trials; 3) addressing the
      ethical, legal, social, and biospecimen- and data-sharing implications of
      pharmacogenomic and pharmacoepidemiologic research; and 4) establishing
      partnerships across NCI, with other federal agencies, and with industry.
      Together, these recommendations will facilitate the discovery and validation of
      clinical, sociodemographic, lifestyle, and genomic markers related to cancer
      treatment response and adverse events, and they will improve both the speed and
      efficiency by which new pharmacogenomic and pharmacoepidemiologic information is 
      translated into clinical practice.
FAU - Freedman, Andrew N
AU  - Freedman AN
AD  - National Cancer Institute, National Institutes of Health, Bethesda, MD
      20892-7393, USA. andrew_freedman@nih.gov
FAU - Sansbury, Leah B
AU  - Sansbury LB
FAU - Figg, William D
AU  - Figg WD
FAU - Potosky, Arnold L
AU  - Potosky AL
FAU - Weiss Smith, Sheila R
AU  - Weiss Smith SR
FAU - Khoury, Muin J
AU  - Khoury MJ
FAU - Nelson, Stefanie A
AU  - Nelson SA
FAU - Weinshilboum, Richard M
AU  - Weinshilboum RM
FAU - Ratain, Mark J
AU  - Ratain MJ
FAU - McLeod, Howard L
AU  - McLeod HL
FAU - Epstein, Robert S
AU  - Epstein RS
FAU - Ginsburg, Geoffrey S
AU  - Ginsburg GS
FAU - Schilsky, Richard L
AU  - Schilsky RL
FAU - Liu, Geoffrey
AU  - Liu G
FAU - Flockhart, David A
AU  - Flockhart DA
FAU - Ulrich, Cornelia M
AU  - Ulrich CM
FAU - Davis, Robert L
AU  - Davis RL
FAU - Lesko, Lawrence J
AU  - Lesko LJ
FAU - Zineh, Issam
AU  - Zineh I
FAU - Randhawa, Gurvaneet
AU  - Randhawa G
FAU - Ambrosone, Christine B
AU  - Ambrosone CB
FAU - Relling, Mary V
AU  - Relling MV
FAU - Rothman, Nat
AU  - Rothman N
FAU - Xie, Heng
AU  - Xie H
FAU - Spitz, Margaret R
AU  - Spitz MR
FAU - Ballard-Barbash, Rachel
AU  - Ballard-Barbash R
FAU - Doroshow, James H
AU  - Doroshow JH
FAU - Minasian, Lori M
AU  - Minasian LM
LA  - eng
GR  - R01 CA132780/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101013
PL  - United States
TA  - J Natl Cancer Inst
JT  - Journal of the National Cancer Institute
JID - 7503089
RN  - 0 (Antineoplastic Agents)
SB  - IM
CIN - J Natl Cancer Inst. 2011 Oct 19;103(20):1558-9; author reply 1559-60. PMID:
      21917608
MH  - Animals
MH  - Antineoplastic Agents/adverse effects/pharmacokinetics/*pharmacology
MH  - Clinical Trials as Topic
MH  - Cooperative Behavior
MH  - Drug Approval
MH  - Drug Design
MH  - Genome-Wide Association Study
MH  - Humans
MH  - Information Dissemination
MH  - *Mutation
MH  - Neoplasms/*drug therapy/epidemiology/genetics/metabolism
MH  - *Pharmacoepidemiology
MH  - *Pharmacogenetics
MH  - *Precision Medicine
MH  - Private Sector
MH  - Public Sector
MH  - Retrospective Studies
MH  - Survivors
MH  - United States
MH  - United States Food and Drug Administration
PMC - PMC2982809
EDAT- 2010/10/15 06:00
MHDA- 2010/12/16 06:00
CRDT- 2010/10/15 06:00
PHST- 2010/10/15 06:00 [entrez]
PHST- 2010/10/15 06:00 [pubmed]
PHST- 2010/12/16 06:00 [medline]
AID - djq390 [pii]
AID - 10.1093/jnci/djq390 [doi]
PST - ppublish
SO  - J Natl Cancer Inst. 2010 Nov 17;102(22):1698-705. doi: 10.1093/jnci/djq390. Epub 
      2010 Oct 13.


PMID- 20944060
OWN - NLM
STAT- MEDLINE
DCOM- 20120116
LR  - 20110915
IS  - 1573-286X (Electronic)
IS  - 1079-0632 (Linking)
VI  - 23
IP  - 3
DP  - 2011 Sep
TI  - The ethics of care and treatment of sex offenders.
PG  - 397-413
LID - 10.1177/1079063210382049 [doi]
AB  - The ethics of care acknowledges the importance of establishing and maintaining
      practices that help people to meet their needs, develop and protect basic
      capabilities for problem solving, emotional functioning, and social interaction, 
      and avoid pain and suffering. In this article, we explore the contribution an
      ethics of care perspective can make to work with sex offenders. First, we briefly
      describe five classes of ethical problems evident in work with sex offenders.
      Second, the concept of care is defined and a justification for a version of care 
      theory provided. Third, we apply the care ethical theory to ethical issues with
      sex offenders and demonstrate its value in responding to the five classes of
      problems outlined earlier.
FAU - Ward, Tony
AU  - Ward T
AD  - 1Victoria University of Wellington.
FAU - Salmon, Karen
AU  - Salmon K
LA  - eng
PT  - Journal Article
DEP - 20101013
PL  - United States
TA  - Sex Abuse
JT  - Sexual abuse : a journal of research and treatment
JID - 9506704
SB  - IM
MH  - *Criminals
MH  - Ethical Theory
MH  - *Ethics, Clinical
MH  - Humans
MH  - *Sex Offenses
EDAT- 2010/10/15 06:00
MHDA- 2012/01/17 06:00
CRDT- 2010/10/15 06:00
PHST- 2010/10/15 06:00 [entrez]
PHST- 2010/10/15 06:00 [pubmed]
PHST- 2012/01/17 06:00 [medline]
AID - 1079063210382049 [pii]
AID - 10.1177/1079063210382049 [doi]
PST - ppublish
SO  - Sex Abuse. 2011 Sep;23(3):397-413. doi: 10.1177/1079063210382049. Epub 2010 Oct
      13.


PMID- 20944059
OWN - NLM
STAT- MEDLINE
DCOM- 20120116
LR  - 20110915
IS  - 1573-286X (Electronic)
IS  - 1079-0632 (Linking)
VI  - 23
IP  - 3
DP  - 2011 Sep
TI  - The case of juvenile polygraphy as a clinical ethics dilemma.
PG  - 314-28
LID - 10.1177/1079063210382046 [doi]
AB  - Polygraph interrogations are used by half of all surveyed juvenile sex offender
      (JSO) treatment programs in the United States. This is a distinctive and
      controversial practice that is rarely if ever used with other juvenile delinquent
      populations, and that is rarely used or is banned from JSO treatment programs in 
      other countries. Clinical polygraphy is an ethically sensitive issue because it
      involves mental health therapists in involuntary coercive interrogations of
      minors. This article reviews core mental health professional ethics principles
      for juveniles. JSO polygraphy is used as an illustrative issue for applying human
      rights principles to a practice in light of its benefits, risks, and available
      alternatives.
FAU - Chaffin, Mark
AU  - Chaffin M
AD  - University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA.
      Mark-Chaffin@ouhsc.edu
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20101013
PL  - United States
TA  - Sex Abuse
JT  - Sexual abuse : a journal of research and treatment
JID - 9506704
SB  - IM
MH  - Adolescent
MH  - Criminals/psychology
MH  - *Ethics, Clinical
MH  - Humans
MH  - Juvenile Delinquency/legislation & jurisprudence/psychology
MH  - *Lie Detection
MH  - Minors/*legislation & jurisprudence/psychology
MH  - Sex Offenses/*ethics
MH  - United States
EDAT- 2010/10/15 06:00
MHDA- 2012/01/17 06:00
CRDT- 2010/10/15 06:00
PHST- 2010/10/15 06:00 [entrez]
PHST- 2010/10/15 06:00 [pubmed]
PHST- 2012/01/17 06:00 [medline]
AID - 1079063210382046 [pii]
AID - 10.1177/1079063210382046 [doi]
PST - ppublish
SO  - Sex Abuse. 2011 Sep;23(3):314-28. doi: 10.1177/1079063210382046. Epub 2010 Oct
      13.


PMID- 20944058
OWN - NLM
STAT- MEDLINE
DCOM- 20120116
LR  - 20110915
IS  - 1573-286X (Electronic)
IS  - 1079-0632 (Linking)
VI  - 23
IP  - 3
DP  - 2011 Sep
TI  - Ethical practice in sex offender assessment: consideration of actuarial and
      polygraph methods.
PG  - 381-96
LID - 10.1177/1079063210382045 [doi]
AB  - The current generation of community protection laws represents a shift in
      priorities that may see the individual rights of sex offenders compromised for
      the goal of public safety. At the center of many judicial decisions under these
      laws are the risk assessment reports provided by mental health practitioners. The
      widespread enactment of laws allowing for additional sanctions for sex offenders,
      and a burgeoning research literature regarding the methods used to assess risk
      have served to heighten rather than resolve the ethical concerns associated with 
      professional practice in this area. This article examines ethical issues inherent
      in the use of two assessment methods commonly used with sex offenders in the
      correctional context, focusing on actuarial measures and polygraph tests.
      Properly conducted and adequately reported actuarial findings are considered to
      provide useful information of sufficient accuracy to inform rather than mislead
      judicial decision makers, although careful consideration must be given to the
      limitations of current measures in each individual case. Despite its increasing
      use, polygraph testing is considered controversial, with little consensus
      regarding its accuracy or appropriate applications. On the basis of the current
      state of the professional literature regarding the polygraph, its use with sex
      offenders raises unresolved ethical concerns.
FAU - Vess, James
AU  - Vess J
AD  - School of Psychology, Deakin University, VIC, Australia. jim.vess@deakin.edu.au
LA  - eng
PT  - Journal Article
DEP - 20101013
PL  - United States
TA  - Sex Abuse
JT  - Sexual abuse : a journal of research and treatment
JID - 9506704
SB  - IM
MH  - Decision Making
MH  - *Ethics, Professional
MH  - Humans
MH  - *Lie Detection
MH  - Risk Assessment
MH  - Sex Offenses/*prevention & control/psychology
MH  - *Social Control, Formal
EDAT- 2010/10/15 06:00
MHDA- 2012/01/17 06:00
CRDT- 2010/10/15 06:00
PHST- 2010/10/15 06:00 [entrez]
PHST- 2010/10/15 06:00 [pubmed]
PHST- 2012/01/17 06:00 [medline]
AID - 1079063210382045 [pii]
AID - 10.1177/1079063210382045 [doi]
PST - ppublish
SO  - Sex Abuse. 2011 Sep;23(3):381-96. doi: 10.1177/1079063210382045. Epub 2010 Oct
      13.


PMID- 20942940
OWN - NLM
STAT- MEDLINE
DCOM- 20101229
LR  - 20211020
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 11
DP  - 2010 Oct 13
TI  - Effects of erythropoietin on depressive symptoms and neurocognitive deficits in
      depression and bipolar disorder.
PG  - 97
LID - 10.1186/1745-6215-11-97 [doi]
AB  - BACKGROUND: Depression and bipolar disorder are associated with reduced neural
      plasticity and deficits in memory, attention and executive function. Drug
      treatments for these affective disorders have insufficient clinical effects in a 
      large group and fail to reverse cognitive deficits. There is thus a need for more
      effective treatments which aid cognitive function. Erythropoietin (Epo) is
      involved in neuroplasticity and is a candidate for future treatment of affective 
      disorders. The investigators have demonstrated that a single dose of Epo improves
      cognitive function and reduces neurocognitive processing of negative emotional
      information in healthy and depressed individuals similar to effects seen with
      conventional antidepressants. The current study adds to the previous findings by 
      investigating whether repeated Epo administration has antidepressant effects in
      patients with treatment resistant depression and reverses cognitive impairments
      in these patients and in patients with bipolar disorder in remission.
      METHODS/DESIGN: The trial has a double-blind, placebo-controlled, parallel-group 
      design. 40 patients with treatment-resistant major depression and 40 patients
      with bipolar disorder in remission are recruited and randomised to receive weekly
      infusions of Epo (Eprex; 40,000 IU) or saline (NaCl 0.9%) for 8 weeks.
      Randomisation is stratified for age and gender. The primary outcome parameters
      for the two studies are: depression severity measured with the Hamilton
      Depression Rating Scale 17 items (HDRS-17) 1 in study 1 and, in study 2, verbal
      memory measured with the Rey Auditory Verbal Learning Test (RAVLT) 23. With
      inclusion of 40 patients in each study we obtain 86% power to detect clinically
      relevant differences between intervention and placebo groups on these primary
      outcomes. TRIAL REGISTRATION: The trial is approved by the Local Ethics
      Committee: H-C-2008-092, Danish Medicines Agency: 2612-4020, EudraCT:
      2008-04857-14, Danish Data Agency: 2008-41-2711 and ClinicalTrials.gov: NCT
      00916552.
FAU - Miskowiak, Kamilla W
AU  - Miskowiak KW
AD  - Clinic for Affective Disorders, Department of Psychiatry, Copenhagen University
      Hospital, Rigshospitalet, Copenhagen, Denmark. kamilla@miskowiak.dk
FAU - Vinberg, Maj
AU  - Vinberg M
FAU - Harmer, Catherine J
AU  - Harmer CJ
FAU - Ehrenreich, Hannelore
AU  - Ehrenreich H
FAU - Knudsen, Gitte M
AU  - Knudsen GM
FAU - Macoveanu, Julian
AU  - Macoveanu J
FAU - Hansen, Allan R
AU  - Hansen AR
FAU - Paulson, Olaf B
AU  - Paulson OB
FAU - Siebner, Hartwig R
AU  - Siebner HR
FAU - Kessing, Lars V
AU  - Kessing LV
LA  - eng
SI  - ClinicalTrials.gov/NCT00916552
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20101013
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
RN  - 0 (Antidepressive Agents)
RN  - 11096-26-7 (Erythropoietin)
SB  - IM
MH  - Affect/drug effects
MH  - Antidepressive Agents/*therapeutic use
MH  - Attention/drug effects
MH  - Bipolar Disorder/diagnosis/*drug therapy/psychology
MH  - Clinical Protocols
MH  - Cognition/*drug effects
MH  - Denmark
MH  - Depressive Disorder, Major/diagnosis/*drug therapy/psychology
MH  - Double-Blind Method
MH  - Erythropoietin/*therapeutic use
MH  - Executive Function/drug effects
MH  - Humans
MH  - Memory/drug effects
MH  - Neuronal Plasticity/drug effects
MH  - Neuropsychological Tests
MH  - Placebo Effect
MH  - Psychiatric Status Rating Scales
MH  - Research Design
MH  - Surveys and Questionnaires
MH  - Time Factors
MH  - Treatment Outcome
PMC - PMC2967509
EDAT- 2010/10/15 06:00
MHDA- 2010/12/30 06:00
CRDT- 2010/10/15 06:00
PHST- 2010/03/16 00:00 [received]
PHST- 2010/10/13 00:00 [accepted]
PHST- 2010/10/15 06:00 [entrez]
PHST- 2010/10/15 06:00 [pubmed]
PHST- 2010/12/30 06:00 [medline]
AID - 1745-6215-11-97 [pii]
AID - 10.1186/1745-6215-11-97 [doi]
PST - epublish
SO  - Trials. 2010 Oct 13;11:97. doi: 10.1186/1745-6215-11-97.


PMID- 20941926
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20101014
IS  - 0017-7768 (Print)
IS  - 0017-7768 (Linking)
VI  - 149
IP  - 6
DP  - 2010 Jun
TI  - [Placebo use in clinical studies].
PG  - 365-9, 403
AB  - Placebo use in clinical settings was first reported in the 1930's.
      Placebo-controlled randomized trials are conducted in order to explore the
      efficacy of new treatments. Nevertheless, the ethical aspects of placebo use
      remain controversial. It is usually accepted that placebo should be used only in 
      circumstances where it causes no significant discomfort. Yet, the term
      "significant discomfort" may be interpreted in different ways. There is evidence 
      that the placebo may be effective in some settings, and in other circumstances
      may be associated with side effects. Herein, we discuss the ethical dilemmas of
      placebo use, the evidence for its benefit or lack of benefit, and the current
      guidelines for conducting placebo-controlled trials.
FAU - Nussinovitch, Udi
AU  - Nussinovitch U
AD  - Department of Medicine B, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
FAU - Eidelman, Leonid
AU  - Eidelman L
FAU - Shoenfeld, Yehuda
AU  - Shoenfeld Y
LA  - heb
PT  - English Abstract
PT  - Journal Article
PL  - Israel
TA  - Harefuah
JT  - Harefuah
JID - 0034351
RN  - 0 (Placebos)
SB  - IM
MH  - Ethics, Medical
MH  - Humans
MH  - *Placebos/adverse effects
MH  - Practice Guidelines as Topic
MH  - *Randomized Controlled Trials as Topic
MH  - Reproducibility of Results
MH  - Risk Assessment
EDAT- 2010/10/15 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/10/15 06:00
PHST- 2010/10/15 06:00 [entrez]
PHST- 2010/10/15 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
PST - ppublish
SO  - Harefuah. 2010 Jun;149(6):365-9, 403.


PMID- 20930229
OWN - NLM
STAT- MEDLINE
DCOM- 20101025
LR  - 20101008
IS  - 1930-7837 (Electronic)
IS  - 0022-0337 (Linking)
VI  - 74
IP  - 10 Suppl
DP  - 2010 Oct
TI  - Reflections on the dental Pipeline program's efforts regarding community-based
      dental education.
PG  - S62-66
AB  - Although many changes are being made, many are still needed in educating future
      dental professionals about prevention programs, ethics, professionalism,
      communication, cultural competence, and access to care. It is not yet clear if
      producing more dentists will put these professionals into underserved areas where
      they are needed, with the skills they need. The achievements of the Pipeline,
      Profession, and Practice: Community-Based Dental Education program schools in
      increasing the amount of time students spend in community-based education and
      service-learning programs result from a widespread, national effort to meet this 
      challenge. This article is a personal reflection and review of these programs,
      considering what has been learned and still needs to be learned about student
      educational impact and quality, faculty issues, program management,
      infrastructure and logistics, and financial impact, with suggestions for future
      study that can help dental schools design the most effective programs.
FAU - Hood, Janet Grobe
AU  - Hood JG
AD  - Department of Restorative Dentistry and Biomaterials, University of Texas Health 
      Science Center at Houston, Dental Branch, Houston, TX 77030, USA.
      Janet.C.Grobe@uth.tmc.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Dent Educ
JT  - Journal of dental education
JID - 8000150
SB  - IM
MH  - Community Dentistry/*education
MH  - Community Health Services/organization & administration
MH  - Education, Dental/methods/*organization & administration/*standards
MH  - Faculty, Dental
MH  - Financial Management
MH  - Healthcare Disparities
MH  - Humans
MH  - *Interinstitutional Relations
MH  - Medically Underserved Area
MH  - *Models, Educational
MH  - Program Evaluation
MH  - Schools, Dental
MH  - Students, Dental
MH  - Texas
MH  - United States
EDAT- 2010/10/15 06:00
MHDA- 2010/10/26 06:00
CRDT- 2010/10/09 06:00
PHST- 2010/10/09 06:00 [entrez]
PHST- 2010/10/15 06:00 [pubmed]
PHST- 2010/10/26 06:00 [medline]
AID - 74/10_suppl/S62 [pii]
PST - ppublish
SO  - J Dent Educ. 2010 Oct;74(10 Suppl):S62-66.


PMID- 20930226
OWN - NLM
STAT- MEDLINE
DCOM- 20101025
LR  - 20220311
IS  - 1930-7837 (Electronic)
IS  - 0022-0337 (Linking)
VI  - 74
IP  - 10 Suppl
DP  - 2010 Oct
TI  - The impact of community-based dental education on students.
PG  - S42-55
AB  - Community-based dental education (CBDE) shifts a substantial portion of dental
      clinical education from dental school clinics to mainly public health settings.
      For dental students to learn effectively in community settings they need
      preparatory education in cultural awareness, communication skills, and the social
      and behavioral sciences. The effective integration of CBDE into a dental
      curriculum requires reflective components, evaluation, and highly organized
      community-based experiences. This chapter reviews organizational principles and
      specific strategies to ensure that CBDE is conducted in a fashion that enables
      student learning and community oral health service. CBDE has substantial
      potential for affecting the values and behaviors of dental students relative to
      health care access for underserved populations and for attracting diverse
      students to dental education. CBDE also provides dentistry with an opportunity to
      guide dental faculty and student values and orientation towards public service,
      engagement, ethics, and the health of the public.
FAU - Strauss, Ronald P
AU  - Strauss RP
AD  - University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3000, USA.
      ron_strauss@unc.edu
FAU - Stein, Margot B
AU  - Stein MB
FAU - Edwards, Jeffrey
AU  - Edwards J
FAU - Nies, Kevin C
AU  - Nies KC
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Dent Educ
JT  - Journal of dental education
JID - 8000150
SB  - IM
MH  - Career Choice
MH  - Communication
MH  - Community Dentistry/*education
MH  - Community Health Services/organization & administration
MH  - Cultural Competency
MH  - Curriculum
MH  - Education, Dental/methods/*organization & administration
MH  - Healthcare Disparities
MH  - Humans
MH  - Interpersonal Relations
MH  - Minority Groups/education
MH  - Motivation
MH  - North Carolina
MH  - Orientation
MH  - Schools, Dental
MH  - Self-Assessment
MH  - Social Responsibility
MH  - Social Values
MH  - *Students, Dental
MH  - United States
EDAT- 2010/10/15 06:00
MHDA- 2010/10/26 06:00
CRDT- 2010/10/09 06:00
PHST- 2010/10/09 06:00 [entrez]
PHST- 2010/10/15 06:00 [pubmed]
PHST- 2010/10/26 06:00 [medline]
AID - 74/10_suppl/S42 [pii]
PST - ppublish
SO  - J Dent Educ. 2010 Oct;74(10 Suppl):S42-55.


PMID- 20941634
OWN - NLM
STAT- MEDLINE
DCOM- 20120404
LR  - 20220129
IS  - 1436-3771 (Electronic)
IS  - 1432-6981 (Linking)
VI  - 15
IP  - 6
DP  - 2011 Dec
TI  - An in vitro evaluation of selective demineralised enamel removal using bio-active
      glass air abrasion.
PG  - 895-900
LID - 10.1007/s00784-010-0470-2 [doi]
AB  - Unnecessary over-preparation of carious enamel often occurs clinically during
      operative caries management. The working hypothesis to be investigated in this
      study is the potential for bio-active glass air abrasion to remove selectively
      only demineralised enamel in artificial enamel lesions when compared to
      equivalent alumina air abrasion, so potentially minimising cavity
      over-preparation. Bisected artificial, paired smooth surface enamel lesions on
      ethics-approved, extracted sound human molars were created and subsequently air
      abraded with 27 mum alumina (n = 19) and bio-active glass (n = 19). The
      difference between pre-operative lesion boundary and post-operative cavity margin
      was calculated following optical confocal fluorescent assessment of the lesion
      boundary. Data indicated mean% over-preparation (sound enamel removal) of 176%
      with alumina and 15.2% for bio-active glass (p = 0.005). Bio-active glass
      abrasion removed completely the demineralised enamel from artificial lesions with
      clinically insignificant over-preparation of sound tissue, indicating technique
      selectivity towards grossly demineralised enamel. Alumina air abrasion resulted
      in substantial enamel removal in both sound and demineralised tissues indicating 
      the operator selectivity required to use the techniques effectively in clinical
      practice.
FAU - Banerjee, Avijit
AU  - Banerjee A
AD  - Department of Biomaterials, King's College London Dental Institute at Guy's,
      King's College and St. Thomas' Hospitals, King's College London, London, UK.
      avijit.banerjee@kcl.ac.uk
FAU - Pabari, Hiten
AU  - Pabari H
FAU - Paolinelis, George
AU  - Paolinelis G
FAU - Thompson, Ian D
AU  - Thompson ID
FAU - Watson, Timothy F
AU  - Watson TF
LA  - eng
GR  - II-3A-1109-10046/DH_/Department of Health/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20101013
PL  - Germany
TA  - Clin Oral Investig
JT  - Clinical oral investigations
JID - 9707115
RN  - 0 (Dental Materials)
RN  - 0 (Fluorescent Dyes)
RN  - 0 (Rhodamines)
RN  - 0 (bioactive glass 45S5)
RN  - K7G5SCF8IL (rhodamine B)
RN  - LMI26O6933 (Aluminum Oxide)
MH  - Air Abrasion, Dental/instrumentation/*methods
MH  - Aluminum Oxide/chemistry
MH  - Ceramics
MH  - Dental Cavity Preparation/methods
MH  - Dental Enamel/*pathology
MH  - Dental Materials/*chemistry
MH  - Fluorescent Dyes
MH  - Glass/*chemistry
MH  - Humans
MH  - Materials Testing
MH  - Microscopy, Confocal
MH  - Rhodamines
MH  - Time Factors
MH  - Tooth Demineralization/pathology/*therapy
EDAT- 2010/10/14 06:00
MHDA- 2012/04/05 06:00
CRDT- 2010/10/14 06:00
PHST- 2010/06/24 00:00 [received]
PHST- 2010/09/28 00:00 [accepted]
PHST- 2010/10/14 06:00 [entrez]
PHST- 2010/10/14 06:00 [pubmed]
PHST- 2012/04/05 06:00 [medline]
AID - 10.1007/s00784-010-0470-2 [doi]
PST - ppublish
SO  - Clin Oral Investig. 2011 Dec;15(6):895-900. doi: 10.1007/s00784-010-0470-2. Epub 
      2010 Oct 13.


PMID- 20940523
OWN - NLM
STAT- MEDLINE
DCOM- 20101115
LR  - 20161125
IS  - 0018-1994 (Print)
IS  - 0018-1994 (Linking)
VI  - 56
IP  - 9
DP  - 2010 Sep
TI  - [Use of 2-octylcyanoacrylate tissue glue for skin closure in radical retropubic
      prostatectomy].
PG  - 495-8
AB  - 2-Octylcyanoacrylate tissue adhesive (2-OCA ; Dermabond(R) , Ethicon, Inc.,
      Sommerville, New Jersey) is a synthetic tissue adhesive recently used for skin
      closure in the treatment of minor lacerations and minor surgical incisions. We
      have been using this adhesive for wound closure in radical retropubic
      prostatectomy (RRP) since August 2006. Before that we used a skin stapler. We
      assessed the effectiveness of the adhesive as a sole dressing after open radical 
      prostatectomy and compared the economic outcomes of 2-OCA and stapled repair. We 
      retrospectively evaluated patients undergoing RRP for whom 2-OCA (101 patients)
      and a skin stapler (133 patients) were used at our institution. Superficial
      surgical site infection (SSI) was seen in 3 patients in the glue group and 3
      patients in the staple group (p=0.99). Wound dehiscence without SSI was seen in 1
      patient in the glue group. The cost of surgery with 2-OCA was much lower than
      that with the skin stapler. Wound closure using 2-OCA following RRP is acceptable
      and has benefits in terms of surgical costs.
FAU - Shimizu, Takashi
AU  - Shimizu T
AD  - The Department of Urology, Sapporo Medical University.
FAU - Masumori, Naoya
AU  - Masumori N
FAU - Hirobe, Megumi
AU  - Hirobe M
FAU - Hashimoto, Kohei
AU  - Hashimoto K
FAU - Maeda, Toshihiro
AU  - Maeda T
FAU - Fukuta, Fumimasa
AU  - Fukuta F
FAU - Tanaka, Toshiaki
AU  - Tanaka T
FAU - Tsukamoto, Taiji
AU  - Tsukamoto T
LA  - jpn
PT  - Comparative Study
PT  - Journal Article
PL  - Japan
TA  - Hinyokika Kiyo
JT  - Hinyokika kiyo. Acta urologica Japonica
JID - 0421145
RN  - 0 (Cyanoacrylates)
RN  - 0 (Tissue Adhesives)
RN  - 6C655P1XVG (octyl 2-cyanoacrylate)
SB  - IM
MH  - Aged
MH  - Cyanoacrylates/*therapeutic use
MH  - Humans
MH  - Male
MH  - Prostatectomy/economics/*methods
MH  - Retrospective Studies
MH  - Surgical Staplers
MH  - Surgical Wound Dehiscence/etiology
MH  - Surgical Wound Infection/etiology
MH  - Tissue Adhesives/*therapeutic use
EDAT- 2010/10/14 06:00
MHDA- 2010/11/16 06:00
CRDT- 2010/10/14 06:00
PHST- 2010/10/14 06:00 [entrez]
PHST- 2010/10/14 06:00 [pubmed]
PHST- 2010/11/16 06:00 [medline]
PST - ppublish
SO  - Hinyokika Kiyo. 2010 Sep;56(9):495-8.


PMID- 20940501
OWN - NLM
STAT- MEDLINE
DCOM- 20101115
LR  - 20101013
IS  - 1881-6096 (Print)
IS  - 1881-6096 (Linking)
VI  - 62
IP  - 10
DP  - 2010 Oct
TI  - [Research resource network and Parkinson disease brain bank donor registration
      program in Japan].
PG  - 1025-34
AB  - In spite of the increasing need for brain tissue in biomedical research, overall 
      brain banking activities in Japan has been lagging behind. On the initiative of
      the National Center of Neurology and Psychiatry, 2 projects have been carried
      out; the Research Resource Network (RRN) and the Parkinson's Disease Brain Bank
      (PDBB) donor registration program. RRN is a nation-wide network that links 15
      brain repositories, and 1,463 autopsy brains have been registered in this network
      as of December 2009. The brain donor registration program for PDBB was
      established in 2006. A donor without cognitive impairment can enroll in this PDBB
      donor registration program. When the donor dies, the next-of-kin will contact the
      PDBB coordinators for subsequent autopsy services and brain retention. On
      obtaining the next-of-kin's consent at the time of donor's death, autopsy will be
      performed at PDBB collaborating hospitals of National Center of Neurology and
      Psychiatry, Juntendo University Hospital, and Tokyo Metropolitan Geriatric
      Hospital. In order to arouse public interest, lecture meetings for citizens have 
      been held on a regular basis. Fifty individuals have registered in the PDBB donor
      registration program including 27 patients with PD, 4 patient with Parkinson
      syndrome, 1 patient with progressive supranuclear palsy, and 18 individuals
      without PD or related disorders as of December 2009. Autopsies have been
      performed for 2 of these donors. To promote brain banking activities,it is
      necessary to establish legal and ethical guidelines for the use of autopsied
      materials in biomedical research.
FAU - Arima, Kunimasa
AU  - Arima K
AD  - Department of Psychiatry, National Center of Neurology and Psychiatry Hospital,
      Ogawa-higashi-machi, Kadaira-shi, Tokyo, Japan.
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Brain Nerve
JT  - Brain and nerve = Shinkei kenkyu no shinpo
JID - 101299709
SB  - IM
MH  - *Brain
MH  - Humans
MH  - Informed Consent
MH  - Japan
MH  - Parkinson Disease/*pathology
MH  - Registries
MH  - Research
MH  - Tissue Banks/*trends
MH  - Tissue Donors
MH  - Tissue Preservation
EDAT- 2010/10/14 06:00
MHDA- 2010/11/16 06:00
CRDT- 2010/10/14 06:00
PHST- 2010/10/14 06:00 [entrez]
PHST- 2010/10/14 06:00 [pubmed]
PHST- 2010/11/16 06:00 [medline]
AID - 1416100761 [pii]
PST - ppublish
SO  - Brain Nerve. 2010 Oct;62(10):1025-34.


PMID- 20940182
OWN - NLM
STAT- MEDLINE
DCOM- 20110527
LR  - 20220318
IS  - 1477-0970 (Electronic)
IS  - 1352-4585 (Linking)
VI  - 17
IP  - 2
DP  - 2011 Feb
TI  - Abdominal massage for the alleviation of constipation symptoms in people with
      multiple sclerosis: a randomized controlled feasibility study.
PG  - 223-33
LID - 10.1177/1352458510384899 [doi]
AB  - BACKGROUND: Constipation affects many people with multiple sclerosis (MS),
      negatively impacting on their quality of life. The use of abdominal massage has
      been reported in several populations and has been shown to increase the frequency
      of defaecation. OBJECTIVE: The objective of this study was to determine the
      feasibility of undertaking abdominal massage in people with MS. METHODS:
      Following ethical approval, 30 patients with MS and constipation were recruited. 
      After providing informed written consent and completion of baseline outcome
      measures, participants were randomly allocated to a massage group or a control
      group. The massage group participants were provided with advice on bowel
      management, and they or their carers were taught how to deliver abdominal massage
      and were recommended to perform it daily during the 4-week intervention period.
      The control group received bowel management advice only. Outcomes were measured
      pre (Week 0) and post treatment (Week 4), and at Week 8 and included: the
      Constipation Scoring System (CSS) (primary outcome), the Neurogenic Bowel
      Dysfunction Score, and a bowel diary. RESULTS: Both groups demonstrated a
      decrease in CSS score from Week 0 to Week 4, indicating an improvement in
      constipation symptoms; however, the massage group improved significantly more
      than the control groups (mean difference between groups in score change -5.0 (SD 
      1.5), 95% CI -8.1, -1.8; t = -3.28, df = 28, p = 0.003). CONCLUSION: The results 
      of this small study suggest a positive effect of the intervention on the symptoms
      of constipation, and support the feasibility of a substantive trial of abdominal 
      massage for the alleviation of the symptoms of constipation in people with MS.
FAU - McClurg, Doreen
AU  - McClurg D
AD  - Nursing, Midwifery and Allied Health Professions Research Unit, Glasgow
      Caledonian University, Glasgow, UK. Doreen.mcclurg@gcal.ac.uk
FAU - Hagen, Suzanne
AU  - Hagen S
FAU - Hawkins, Stanley
AU  - Hawkins S
FAU - Lowe-Strong, Andrea
AU  - Lowe-Strong A
LA  - eng
GR  - NMAHP2/CSO_/Chief Scientist Office/United Kingdom
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20101012
PL  - England
TA  - Mult Scler
JT  - Multiple sclerosis (Houndmills, Basingstoke, England)
JID - 9509185
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Chi-Square Distribution
MH  - Constipation/etiology/physiopathology/*therapy
MH  - *Defecation
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - *Massage
MH  - Middle Aged
MH  - Multiple Sclerosis/*complications/physiopathology
MH  - Northern Ireland
MH  - Recovery of Function
MH  - Severity of Illness Index
MH  - Surveys and Questionnaires
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2010/10/14 06:00
MHDA- 2011/05/28 06:00
CRDT- 2010/10/14 06:00
PHST- 2010/10/14 06:00 [entrez]
PHST- 2010/10/14 06:00 [pubmed]
PHST- 2011/05/28 06:00 [medline]
AID - 1352458510384899 [pii]
AID - 10.1177/1352458510384899 [doi]
PST - ppublish
SO  - Mult Scler. 2011 Feb;17(2):223-33. doi: 10.1177/1352458510384899. Epub 2010 Oct
      12.


PMID- 20940175
OWN - NLM
STAT- MEDLINE
DCOM- 20110315
LR  - 20101129
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 12
DP  - 2010 Dec
TI  - Enhancing the fairness of pandemic critical care triage.
PG  - 758-61
LID - 10.1136/jme.2010.035501 [doi]
AB  - Historically, the triage of temporarily scarce health resources has served narrow
      utilitarian ends. The recent H1N1 pandemic experience provided an opportunity for
      expanding the theoretical foundations/understandings of critical care triage in
      the context of declared infectious pandemics. This paper briefly explores the
      ethics-related challenges associated with the development of modern critical care
      triage protocols and provides descriptions of some 'enhanced fairness' features
      which were developed through the use of an inclusive deliberative engagement
      process by a Canadian provincial Department of Health.
FAU - Kirby, Jeffrey
AU  - Kirby J
AD  - Department of Bioethics, Faculty of Medicine, Dalhousie University, C-320, 5849
      University Avenue, Halifax, NS B3H 3J3, Canada. jeffrey.kirby@dal.ca
LA  - eng
PT  - Journal Article
DEP - 20101012
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Clinical Protocols/standards
MH  - *Critical Care
MH  - Disease Outbreaks/*ethics
MH  - Health Care Rationing/*ethics
MH  - Health Priorities/*ethics
MH  - Health Resources/organization & administration
MH  - Humans
MH  - Resource Allocation/*ethics
MH  - Triage/*ethics
EDAT- 2010/10/14 06:00
MHDA- 2011/03/16 06:00
CRDT- 2010/10/14 06:00
PHST- 2010/10/14 06:00 [entrez]
PHST- 2010/10/14 06:00 [pubmed]
PHST- 2011/03/16 06:00 [medline]
AID - jme.2010.035501 [pii]
AID - 10.1136/jme.2010.035501 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Dec;36(12):758-61. doi: 10.1136/jme.2010.035501. Epub 2010 Oct
      12.


PMID- 20939736
OWN - NLM
STAT- MEDLINE
DCOM- 20110318
LR  - 20211020
IS  - 1945-0257 (Electronic)
IS  - 1945-0257 (Linking)
VI  - 14
IP  - 6
DP  - 2010 Dec
TI  - Researcher practices on returning genetic research results.
PG  - 821-7
LID - 10.1089/gtmb.2010.0066 [doi]
AB  - BACKGROUND/AIMS: as genetic and genomic research proliferates, debate has ensued 
      about returning results to participants. In addition to consideration of the
      benefits and harms to participants, researchers must also consider the logistical
      and financial feasibility of returning research results. However, little data
      exist of actual researcher practices. METHODS: we conducted an online survey of
      446 corresponding authors of genetic/genomic studies conducted in the United
      States and published in 2006-2007 to assess the frequency with which they
      considered, offered to, or actually returned research results, what factors
      influenced these decisions, and the method of communicating results. RESULTS: the
      response rate was 24% (105/446). Fifty-four percent of respondents considered the
      issue of returning research results to participants, 28% offered to return
      individual research results, and 24% actually returned individual research
      results. Of those who considered the issue of returning research results during
      the study planning phase, the most common factors considered were whether
      research results were deemed clinically useful (18%) and respect for participants
      (13%). Researchers who had a medical degree and conducted studies on children
      were significantly more likely to offer to return or actually return individual
      results compared to those with a Ph.D. only. CONCLUSIONS: we speculate that
      issues associated with clinical validity and respect for participants dominated
      concerns of time and expense given the prominent and continuing ethical debates
      surrounding genetics and genomics research. The substantial number of researchers
      who did not consider returning research results suggests that researchers and
      institutional review boards need to devote more attention to a topic about which 
      research participants are interested.
FAU - Heaney, Christopher
AU  - Heaney C
AD  - Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina
      27708, USA.
FAU - Tindall, Genevieve
AU  - Tindall G
FAU - Lucas, Joe
AU  - Lucas J
FAU - Haga, Susanne B
AU  - Haga SB
LA  - eng
GR  - 5UL-1-RR-204128/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20101012
PL  - United States
TA  - Genet Test Mol Biomarkers
JT  - Genetic testing and molecular biomarkers
JID - 101494210
SB  - IM
MH  - Access to Information
MH  - Data Collection
MH  - *Genetic Research
MH  - *Genetic Testing
MH  - Humans
MH  - *Professional Practice
MH  - Research Personnel/*psychology
MH  - United States
PMC - PMC3001830
EDAT- 2010/10/14 06:00
MHDA- 2011/03/19 06:00
CRDT- 2010/10/14 06:00
PHST- 2010/10/14 06:00 [entrez]
PHST- 2010/10/14 06:00 [pubmed]
PHST- 2011/03/19 06:00 [medline]
AID - 10.1089/gtmb.2010.0066 [doi]
PST - ppublish
SO  - Genet Test Mol Biomarkers. 2010 Dec;14(6):821-7. doi: 10.1089/gtmb.2010.0066.
      Epub 2010 Oct 12.


PMID- 20939691
OWN - NLM
STAT- MEDLINE
DCOM- 20110913
LR  - 20211020
IS  - 1557-8534 (Electronic)
IS  - 1547-3287 (Linking)
VI  - 20
IP  - 5
DP  - 2011 May
TI  - Comparative analysis of the retinal potential of embryonic stem cells and
      amniotic fluid-derived stem cells.
PG  - 851-63
LID - 10.1089/scd.2010.0291 [doi]
AB  - Photoreceptors have recently been generated from mouse and human embryonic stem
      cells (ESCs), although ethics concerns impede their utilization for cell
      replacement therapy for retinal disease. Extra-embryonic tissues have received
      attention as alternative therapeutic sources of stem cells. Human and mouse
      amniotic fluid-derived stem cells (AFCs) have been reported to be multipotent and
      express embryonic and adult stem cell markers. Here, in vitro conditions that
      generate retinal cells from ESCs were used to analyze and compare the retinal
      potential of murine AFCs and ESCs. We show that AFCs express pluripotency markers
      (Nanog, Sox2, and Oct3/4) as well as retinal transcription factor genes (Et,
      Lhx2, Tll1, Six6, Otx2, Pax6, and Fgf15). AFCs from amniotic fluid of Fgf15.gfp, 
      Nrl.gfp, and Crx.gfp embryos cultured in retinal proliferation and
      differentiation conditions failed to switch on these retinal transgenes. AFCs
      cultured in retinal-promoting conditions, effective on ESCs, showed reduced
      expression of retinal markers. Retinal co-cultures activated retinal genes in
      ESCs but not in AFCs, and migration assays in retinal explants showed limited
      migration of AFCs compared with ESCs. Unlike ESCs, AFCs do not express the early 
      embryonic ectodermal gene Utf1 and Western analysis of AFCs identified only the B
      isoform of Oct3/4, rather than the isoform A present in ESCs. We conclude that
      AFCs have restricted potential and differ considerably from ESCs and retinal
      progenitor cells. Reprogramming to induce pluripotency or new differentiation
      protocols will be required to confer retinal potential to AFCs as expression of a
      subset of pluripotency and retinal markers is not sufficient.
FAU - Decembrini, Sarah
AU  - Decembrini S
AD  - UCL Institute of Child Health, Great Ormond Street Hospital, London, United
      Kingdom.
FAU - Cananzi, Mara
AU  - Cananzi M
FAU - Gualdoni, Sara
AU  - Gualdoni S
FAU - Battersby, Alysia
AU  - Battersby A
FAU - Allen, Nick
AU  - Allen N
FAU - Pearson, Rachael A
AU  - Pearson RA
FAU - Ali, Robin R
AU  - Ali RR
FAU - De Coppi, Paolo
AU  - De Coppi P
FAU - Sowden, Jane C
AU  - Sowden JC
LA  - eng
GR  - G0700438/MRC_/Medical Research Council/United Kingdom
GR  - 082217/WT_/Wellcome Trust/United Kingdom
GR  - G0901550/MRC_/Medical Research Council/United Kingdom
GR  - G03000341/MRC_/Medical Research Council/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101206
PL  - United States
TA  - Stem Cells Dev
JT  - Stem cells and development
JID - 101197107
RN  - 0 (Biomarkers)
RN  - 0 (Chromosomal Proteins, Non-Histone)
RN  - 0 (Culture Media)
RN  - 0 (Protein Isoforms)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - 0 (Utf1 protein, mouse)
SB  - IM
MH  - Amniotic Fluid/*cytology/metabolism
MH  - Animals
MH  - Biomarkers/analysis
MH  - Cell Culture Techniques
MH  - Cell Differentiation
MH  - Cell Line
MH  - Cell Movement
MH  - Chromosomal Proteins, Non-Histone
MH  - Coculture Techniques/methods
MH  - Culture Media/chemistry/metabolism
MH  - Embryonic Stem Cells/*cytology/metabolism
MH  - Female
MH  - Mice
MH  - Organ Culture Techniques/methods
MH  - Pluripotent Stem Cells/*cytology/metabolism
MH  - Protein Isoforms/analysis/biosynthesis
MH  - Retina/*cytology/metabolism
MH  - Retinal Diseases/therapy
MH  - Stem Cell Transplantation/*methods
MH  - Tissue Engineering/*methods
MH  - Trans-Activators/deficiency
MH  - Transcription Factors/analysis/biosynthesis
EDAT- 2010/10/14 06:00
MHDA- 2011/09/14 06:00
CRDT- 2010/10/14 06:00
PHST- 2010/10/14 06:00 [entrez]
PHST- 2010/10/14 06:00 [pubmed]
PHST- 2011/09/14 06:00 [medline]
AID - 10.1089/scd.2010.0291 [doi]
PST - ppublish
SO  - Stem Cells Dev. 2011 May;20(5):851-63. doi: 10.1089/scd.2010.0291. Epub 2010 Dec 
      6.


PMID- 20939239
OWN - NLM
STAT- MEDLINE
DCOM- 20101124
LR  - 20101013
IS  - 0300-9041 (Print)
IS  - 0300-9041 (Linking)
VI  - 78
IP  - 5
DP  - 2010 May
TI  - [Complaints from medical care in obstetrics and gynecology].
PG  - 281-6
AB  - BACKGROUND: The fulfillment and satisfaction regarding the expectations of the
      patients at services of obstetrics and gynecology, it is related to the quality
      of care. Failure to meet these expectations will rise to the dissatisfaction and 
      enhances the culture of demand, with these considerations this presents study
      were developed, researching the patients complaints reported by the State
      Commission o Medical Arbitration of Oaxaca in 2007 with the aim of identifying
      the medical complaint emphasis on obstetrics care. OBJECTIVE: To identify the
      medical lawsuits to Gineco-obstetricians in Oaxaca. MATERIAL AND METHOD: We
      conducted a documentary research, descriptive, transversal, retrospective and
      without ethical implications, through analysis of databases of the State
      Commission of Medical Arbitration of Oaxaca, corresponding to 2007 activity
      report; 100% of selected records were medical complaints in the specialty of
      gynecology-obstetrics. RESULTS: The attention given to 10.5% are disagreements or
      complaints which medical complaints in gynecology-obstetrics specialty are second
      with 21% and the report file complaints state ranks first with 12.3% of cases,
      70% of medical care is provided by gynecologists and total complaints, 40% were
      confined to expert medical advice. CONCLUSIONS: Complaints in gynecological and
      obstetric care rank first places relative to other specialties, the attention
      given in the two-thirds is provided by medical specialists in obstetrics and
      gynecology, and less than the half were certified by the Board and expert medical
      opinions reported evidence of malpractice and corporate responsibility in the
      complaints.
FAU - Noguera-Sanchez, Marcelo Fidias
AU  - Noguera-Sanchez MF
AD  - Subsecretaria de Innovacion y Calidad, Oaxaca de Juarez, Oax.
      fidiasnoguera@yahoo.com.mx
FAU - Garcia-Kavanagh, Rosalilia
AU  - Garcia-Kavanagh R
FAU - Cruz-Rojas, Roberto Efrain
AU  - Cruz-Rojas RE
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - La queja medica derivada de la atencion en ginecoobstetricia.
PL  - Mexico
TA  - Ginecol Obstet Mex
JT  - Ginecologia y obstetricia de Mexico
JID - 0376552
SB  - IM
MH  - Cross-Sectional Studies
MH  - Female
MH  - *Gynecology
MH  - Health Facilities/classification/statistics & numerical data
MH  - Humans
MH  - Malpractice/*statistics & numerical data
MH  - Mexico
MH  - Negotiating
MH  - *Obstetrics
MH  - *Patient Satisfaction
MH  - *Quality of Health Care
MH  - Retrospective Studies
EDAT- 2010/10/14 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/10/14 06:00
PHST- 2010/10/14 06:00 [entrez]
PHST- 2010/10/14 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - Ginecol Obstet Mex. 2010 May;78(5):281-6.


PMID- 20939132
OWN - HMD
STAT- MEDLINE
DCOM- 20101230
LR  - 20191111
IS  - 0002-9246 (Print)
IS  - 0002-9246 (Linking)
VI  - 69
IP  - 4
DP  - 2010
TI  - The economics and ethics of Hurricane Katrina.
PG  - 1294-1320
AB  - How might free enterprise have dealt with Hurricane Katrina and her aftermath.
      This article probes this question at increasing levels of radicalization,
      starting with the privatization of several government "services" and ending with 
      the privatization of all of them.
FAU - Rockwell, Llewellyn H Jr
AU  - Rockwell LH Jr
AD  - Ludwig von Mises Institute.
FAU - Block, Walter E
AU  - Block WE
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - Am J Econ Sociol
JT  - American journal of economics and sociology
JID - 14820160R
MH  - *Cyclonic Storms/economics/history
MH  - *Disaster Planning/economics/history/legislation & jurisprudence
MH  - Disasters/economics/history
MH  - *Government Agencies/economics/history/legislation & jurisprudence
MH  - History, 21st Century
MH  - Louisiana/ethnology
MH  - *Privatization/economics/history/legislation & jurisprudence
MH  - *Public Policy/economics/history/legislation & jurisprudence
MH  - Public Sector/economics/history/legislation & jurisprudence
EDAT- 2010/10/14 06:00
MHDA- 2010/12/31 06:00
CRDT- 2010/10/14 06:00
PHST- 2010/10/14 06:00 [entrez]
PHST- 2010/10/14 06:00 [pubmed]
PHST- 2010/12/31 06:00 [medline]
AID - 10.1111/j.1536-7150.2010.00745.x [doi]
PST - ppublish
SO  - Am J Econ Sociol. 2010;69(4):1294-1320. doi: 10.1111/j.1536-7150.2010.00745.x.


PMID- 20938898
OWN - NLM
STAT- MEDLINE
DCOM- 20110623
LR  - 20110217
IS  - 1439-359X (Electronic)
IS  - 0939-7248 (Linking)
VI  - 21
IP  - 1
DP  - 2011 Jan
TI  - Surgical repair of incarcerated inguinal hernia in children: laparoscopic or
      open?
PG  - 8-11
LID - 10.1055/s-0030-1262793 [doi]
AB  - PURPOSE: The management of Incarcerated Inguinal Hernia (IIH) in children is
      challenging and may be associated with complications. We aimed to compare the
      outcomes of laparoscopic vs. open repair of IIH. METHODS: With institutional
      ethical approval (09SG13), we reviewed the notes of 63 consecutive children who
      were admitted to a single hospital with the diagnosis of IIH between 2000 and
      2008. Data are reported as median (range). Groups were compared by chi-squared or
      t-tests as appropriate. RESULTS: . Open repair (n=35): There were 21 children
      with right and 14 with left IIH. 2 patients also had contralateral reducible
      inguinal hernia. Small bowel resection was required in 2 children. . Laparoscopic
      repair (n=28): All children had unilateral IIH (19 right sided, 9 left sided). 15
      children (54%) with no clinical evidence of contralateral hernia, had
      contralateral patent processus vaginalis at laparoscopy, which was also repaired.
      The groups were similar with regard to gender, age at surgery, history of
      prematurity, interval between admission and surgery, and proportion of patients
      with successful preoperative manual reduction. However, the duration of operation
      was longer in the laparoscopy group (p=0.01). Time to full feeds and length of
      hospital stay were similar in both groups. Postoperative follow-up was 3.5 months
      (1-36), which was similar in both groups. 5 patients in the group undergoing open
      repair had serious complications: 1 vas transaction, 1 acquired undescended
      testis, 2 testicular atrophy and 1 recurrence. The laparoscopic group had a
      single recurrence. CONCLUSION: Open repair of incarcerated inguinal hernia is
      associated with serious complications. The laparoscopic technique appears safe,
      avoids the difficult dissection of an oedematous sac in the groin, allows
      inspection of the reduced hernia content and permits the repair of a
      contralateral patent processus vaginalis if present.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Nah, S A
AU  - Nah SA
AD  - UCL Institute of Child Health & Great Ormond Street Hospital for Children, Unit
      of Paediatric Surgery, London, United Kingdom.
FAU - Giacomello, L
AU  - Giacomello L
FAU - Eaton, S
AU  - Eaton S
FAU - de Coppi, P
AU  - de Coppi P
FAU - Curry, J I
AU  - Curry JI
FAU - Drake, D P
AU  - Drake DP
FAU - Kiely, E M
AU  - Kiely EM
FAU - Pierro, A
AU  - Pierro A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20101011
PL  - United States
TA  - Eur J Pediatr Surg
JT  - European journal of pediatric surgery : official journal of Austrian Association 
      of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie
JID - 9105263
SB  - IM
MH  - Child, Preschool
MH  - Female
MH  - Hernia, Inguinal/*surgery
MH  - Humans
MH  - Infant
MH  - Laparoscopy/*methods
MH  - Male
MH  - Postoperative Complications
MH  - Treatment Outcome
EDAT- 2010/10/13 06:00
MHDA- 2011/06/24 06:00
CRDT- 2010/10/13 06:00
PHST- 2010/10/13 06:00 [entrez]
PHST- 2010/10/13 06:00 [pubmed]
PHST- 2011/06/24 06:00 [medline]
AID - 10.1055/s-0030-1262793 [doi]
PST - ppublish
SO  - Eur J Pediatr Surg. 2011 Jan;21(1):8-11. doi: 10.1055/s-0030-1262793. Epub 2010
      Oct 11.


PMID- 20938870
OWN - NLM
STAT- MEDLINE
DCOM- 20110204
LR  - 20110616
IS  - 1529-9740 (Electronic)
IS  - 1529-9732 (Linking)
VI  - 11
IP  - 4
DP  - 2010
TI  - The expected psychiatric impact of detention in Guantanamo Bay, Cuba, and related
      considerations.
PG  - 469-87
LID - 10.1080/15299732.2010.496074 [doi]
AB  - What are the likely mental and related physical health consequences of prolonged 
      exposure to common stressors to detainees at Guantanamo Bay, Cuba? Significant
      distress leads to high rates of psychiatric disorders, medical problems, and
      functional impairments. The consequences are severe, physically and
      psychologically, affecting the individual, his or her family, and the culture at 
      large. Damaging conditions endured by detainees are multiple and severe and are
      reviewed here in detail. The author identifies parallels between Guantanamo
      detainees and similarly mistreated populations (e.g., prisoners of war, asylum
      seekers, prisoners) to draw inferences from existing research regarding likely
      outcomes for Guantanamo detainees. Protective factors normally present are
      systematically disrupted at Guantanamo. Overall, it is likely that detainees and 
      their families are experiencing significant mental and physical health problems
      as a result of overlapping severe and chronic stressors related to detention and 
      that this will worsen over time, particularly in the absence of appropriate
      assessment and treatment. The author addresses political and ethical factors, as 
      well as basic implications for assessment, treatment, and advocacy, although
      these are not the focus of the article. Researchers and clinicians will face
      challenges in providing care for this population and understanding the long-term 
      effects of such mistreatment. Sources reviewed are current up to September 2009.
FAU - Brenner, Grant Hilary
AU  - Brenner GH
AD  - William Alanson White Institute, New York, New York, USA. GBrenner144@msn.com
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Trauma Dissociation
JT  - Journal of trauma & dissociation : the official journal of the International
      Society for the Study of Dissociation (ISSD)
JID - 100898209
SB  - IM
MH  - Cuba
MH  - Humans
MH  - Mental Disorders/*etiology
MH  - Prisoners/*psychology
MH  - *Prisons
MH  - *Stress, Physiological
MH  - Stress, Psychological/complications
MH  - *Terrorism
MH  - Torture/*psychology
EDAT- 2010/10/13 06:00
MHDA- 2011/02/05 06:00
CRDT- 2010/10/13 06:00
PHST- 2010/10/13 06:00 [entrez]
PHST- 2010/10/13 06:00 [pubmed]
PHST- 2011/02/05 06:00 [medline]
AID - 927938694 [pii]
AID - 10.1080/15299732.2010.496074 [doi]
PST - ppublish
SO  - J Trauma Dissociation. 2010;11(4):469-87. doi: 10.1080/15299732.2010.496074.


PMID- 20938795
OWN - NLM
STAT- MEDLINE
DCOM- 20120404
LR  - 20211020
IS  - 1436-3771 (Electronic)
IS  - 1432-6981 (Linking)
VI  - 15
IP  - 6
DP  - 2011 Dec
TI  - Oral health of Chinese people with systemic sclerosis.
PG  - 931-9
LID - 10.1007/s00784-010-0472-0 [doi]
AB  - The aim was to study oral health status, salivary function, and oral features of 
      Chinese people with Systemic Sclerosis (SSc). Chinese people with SSc attending a
      university specialist clinic were invited for a questionnaire survey and a
      clinical examination. Ethics approval was sought (UW 08-305). Gender- and
      age-matched individuals without SSc who attended a university dental hospital
      were recruited for comparison. Forty-two SSc patients with a mean age of 54.0 +/-
      12.2 were examined. This study found no Chinese people with systemic sclerosis
      were periodontally healthy and many (76%) had periodontal pockets despite most of
      them (93%) practiced daily tooth-brushing. They all had caries experience (DMFT =
      10.5) and many (65%) had untreated decay. Mucosal telangiectasia was a common
      oral feature (80%). They had lower resting salivary flow rates (0.18 +/- 0.17
      ml/min vs. 0.31 +/- 0.21 ml/min; p = 0.003) and pH values (6.90 +/- 0.40 vs. 7.28
      +/- 0.31; p < 0.001) and reduced maximal mouth opening (40.1 +/- 6.5 mm vs. 43.6 
      +/- 7.0 mm) than people without SSc.
FAU - Chu, C H
AU  - Chu CH
AD  - Faculty of Dentistry, The University of Hong Kong, 3B61, Prince Philip Dental
      Hospital, 34 Hospital Road, Hong Kong SAR, China. chchu@hku.hk
FAU - Yeung, Clive M K
AU  - Yeung CM
FAU - Lai, Ian A
AU  - Lai IA
FAU - Leung, W Keung
AU  - Leung WK
FAU - Mok, Mo Yin
AU  - Mok MY
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101012
PL  - Germany
TA  - Clin Oral Investig
JT  - Clinical oral investigations
JID - 9707115
MH  - Case-Control Studies
MH  - China
MH  - DMF Index
MH  - Dental Care
MH  - Dental Caries/complications
MH  - Dental Devices, Home Care
MH  - Female
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Jaw, Edentulous, Partially/complications
MH  - Male
MH  - Middle Aged
MH  - Mouth Diseases/*complications
MH  - Mouth Mucosa/blood supply
MH  - Periodontal Diseases/complications
MH  - Periodontal Pocket/complications
MH  - Saliva/metabolism
MH  - Salivary Gland Diseases/complications
MH  - Scleroderma, Systemic/*complications
MH  - Secretory Rate/physiology
MH  - Telangiectasis/complications
MH  - Tooth Diseases/*complications
MH  - Toothbrushing
MH  - Xerostomia/complications
PMC - PMC3212684
EDAT- 2010/10/13 06:00
MHDA- 2012/04/05 06:00
CRDT- 2010/10/13 06:00
PHST- 2010/07/22 00:00 [received]
PHST- 2010/09/28 00:00 [accepted]
PHST- 2010/10/13 06:00 [entrez]
PHST- 2010/10/13 06:00 [pubmed]
PHST- 2012/04/05 06:00 [medline]
AID - 10.1007/s00784-010-0472-0 [doi]
PST - ppublish
SO  - Clin Oral Investig. 2011 Dec;15(6):931-9. doi: 10.1007/s00784-010-0472-0. Epub
      2010 Oct 12.


PMID- 20938672
OWN - NLM
STAT- MEDLINE
DCOM- 20110225
LR  - 20211020
IS  - 1433-8491 (Electronic)
IS  - 0940-1334 (Linking)
VI  - 260 Suppl 2
DP  - 2010 Nov
TI  - Ethical guidelines in psychiatric research.
PG  - S142-6
LID - 10.1007/s00406-010-0132-z [doi]
AB  - Capacity to consent is a basic prerequisite for participation of patients as
      probands in research. However, mental illness often impairs this competence.
      Therefore, in psychiatric research, the first obligation is to assess a mentally 
      ill patient's competence to consent. This is not a simple task. Informed consent 
      should be viewed not only as a legal must, but also as a chance to build up a
      trusting patient-psychiatrist relationship. This is called for by respect for the
      autonomy and dignity of the patient. Specifically, competence to consent is
      related to the specific intervention; the validity of a consent requires that the
      patient understands the intervention-related medical information, comprehends its
      significance and consequences, and can appreciate its meaning for himself.
      Research with patients who lack this competence to consent validly meets a major 
      problem: an uncovered need for research in frequent major psychiatric disorders
      exists, but a substantial number of patients with these illnesses cannot consent 
      validly. Several guidelines for dealing with this problem will be discussed.
      Mentally ill patients who are willing to participate in needed research are a
      rare resource. This must be protected by the virtue of the clinical researcher
      who has to take great pains over the strict adherence to ethical guidelines.
FAU - Helmchen, Hanfried
AU  - Helmchen H
AD  - Department Psychiatry and Psychotherapy, Charite-University Medicine Berlin,
      Eschenallee 3, 14050 Berlin, Germany. hanfried.helmchen@charite.de
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20101012
PL  - Germany
TA  - Eur Arch Psychiatry Clin Neurosci
JT  - European archives of psychiatry and clinical neuroscience
JID - 9103030
SB  - IM
MH  - *Ethics, Medical
MH  - *Guidelines as Topic
MH  - Humans
MH  - Informed Consent/*ethics/legislation & jurisprudence
MH  - *Mental Disorders/therapy
MH  - Models, Psychological
EDAT- 2010/10/13 06:00
MHDA- 2011/02/26 06:00
CRDT- 2010/10/13 06:00
PHST- 2010/04/09 00:00 [received]
PHST- 2010/07/07 00:00 [accepted]
PHST- 2010/10/13 06:00 [entrez]
PHST- 2010/10/13 06:00 [pubmed]
PHST- 2011/02/26 06:00 [medline]
AID - 10.1007/s00406-010-0132-z [doi]
PST - ppublish
SO  - Eur Arch Psychiatry Clin Neurosci. 2010 Nov;260 Suppl 2:S142-6. doi:
      10.1007/s00406-010-0132-z. Epub 2010 Oct 12.


PMID- 20938425
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20101012
IS  - 0026-4784 (Print)
IS  - 0026-4784 (Linking)
VI  - 62
IP  - 5
DP  - 2010 Oct
TI  - [Optical coherence tomography: preliminary results with a new noninvasive
      technique for evaluating uterine cervical tissue and vulvar epithelium].
PG  - 395-401
AB  - AIM: Optical coherence tomography (OCT) is a noninvasive diagnostic imaging
      technique that captures high-definition real-time images at near-microscopic
      resolution (1-2 mm below the surface) of biological tissue morphology. The aim of
      this study was to define the characteristics of uterine cervical and vulvar
      pathologies by means of OCT and to compare OCT findings versus histopathological 
      features. MATERIALS AND METHODS: This prospective single-center study was
      approved by the regional ethical committee. The OCT scans were performed in women
      with suspected cervical intraepithelial neoplasia (CIN) or vulvar intraepithelial
      neoplasia (VIN). The suspicious lesions were identified using colposcopy,
      visualized by OCT, and then biopsied. The OCT scans were evaluated by two
      independent examiners. The results were then compared with the histopathological 
      findings. The sensitivity and specificity of OCT were calculated. RESULTS:
      Overall, 50 of the 54 CIN and 2 carcinomas confirmed on histology were correctly 
      diagnosed with OCT, yielding a sensitivity of 93%; specificity was 33%, with 8
      false positives and 4 true negatives. In 10 patients with suspected VIN, 19 OCT
      images were compared with the corresponding biopsies. Three states of tissue
      structure could be distinguished, with typical features of normal tissue and
      tissue altered by neoplastic transformation. CONCLUSION: OCT is a noninvasive,
      fast and simple technique to obtain real-time information on tissue
      microstructure. Further study is needed to assess its use in routine diagnostic
      imaging; however, these preliminary results indicate its high sensitivity.
FAU - Gallwas, J
AU  - Gallwas J
AD  - Dipartimento di Ginecologia e Ostetricia, Universita Ludwig-Maximilian, Monaco di
      Baviera, Germania. Julia.Gallwas@med.uni-muenchen.de
FAU - Chiapponi, C
AU  - Chiapponi C
FAU - Turk, L
AU  - Turk L
FAU - Ochsenkuehn, R
AU  - Ochsenkuehn R
FAU - Friese, K
AU  - Friese K
FAU - Dannecker, C
AU  - Dannecker C
LA  - ita
PT  - Clinical Trial
PT  - English Abstract
PT  - Journal Article
TT  - La tomografia a coerenza ottica, una nuova tecnica non invasiva per valutare il
      tessuto cervicale uterino e l'epitelio vulvare. Risultati preliminari.
PL  - Italy
TA  - Minerva Ginecol
JT  - Minerva ginecologica
JID - 0400731
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Carcinoma in Situ/diagnosis
MH  - Cervical Intraepithelial Neoplasia/*diagnosis
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Prospective Studies
MH  - *Tomography, Optical Coherence
MH  - Uterine Cervical Neoplasms/*diagnosis
MH  - Vulvar Neoplasms/*diagnosis
MH  - Young Adult
EDAT- 2010/10/13 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/10/13 06:00
PHST- 2010/10/13 06:00 [entrez]
PHST- 2010/10/13 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - R09103147 [pii]
PST - ppublish
SO  - Minerva Ginecol. 2010 Oct;62(5):395-401.


PMID- 20937795
OWN - NLM
STAT- MEDLINE
DCOM- 20120116
LR  - 20191210
IS  - 1573-286X (Electronic)
IS  - 1079-0632 (Linking)
VI  - 23
IP  - 3
DP  - 2011 Sep
TI  - "But I didn't do it!": ethical treatment of sex offenders in denial.
PG  - 346-64
LID - 10.1177/1079063210382048 [doi]
AB  - This article addresses ethical questions and issues related to the treatment of
      sex offenders in denial, using the empirical research literature and the ethical 
      codes of American Psychological Association (APA) and National Association of
      Social Workers (NASW) to guide the ethical decision-making process. The empirical
      literature does not provide an unequivocal link between denial and recidivism,
      though some studies suggest that decreased denial and increased accountability
      appear to be associated with greater therapeutic engagement and reduced
      recidivism for some offenders. The ethical codes of APA and NASW value the
      client's self-determination and autonomy, and psychologists and social workers
      have a duty to empower individual well-being while doing no harm to clients or
      others. Clinicians should view denial not as a categorical construct but as a
      continuum of distorted cognitions requiring clinical attention. Denial might also
      be considered as a responsivity factor that can interfere with treatment
      progress. Offering a reasonable time period for therapeutic engagement might
      provide a better alternative than automatically refusing treatment to categorical
      deniers.
FAU - Levenson, Jill S
AU  - Levenson JS
AD  - Lynn University, Boca Raton, FL 33431, USA. jlevenson@lynn.edu
LA  - eng
PT  - Journal Article
DEP - 20101011
PL  - United States
TA  - Sex Abuse
JT  - Sexual abuse : a journal of research and treatment
JID - 9506704
SB  - IM
MH  - *Codes of Ethics
MH  - Criminals/*psychology
MH  - *Denial, Psychological
MH  - Humans
MH  - Interpersonal Relations
MH  - Morals
MH  - Patient Rights
MH  - Personal Autonomy
MH  - Sex Offenses/*psychology
EDAT- 2010/10/13 06:00
MHDA- 2012/01/17 06:00
CRDT- 2010/10/13 06:00
PHST- 2010/10/13 06:00 [entrez]
PHST- 2010/10/13 06:00 [pubmed]
PHST- 2012/01/17 06:00 [medline]
AID - 1079063210382048 [pii]
AID - 10.1177/1079063210382048 [doi]
PST - ppublish
SO  - Sex Abuse. 2011 Sep;23(3):346-64. doi: 10.1177/1079063210382048. Epub 2010 Oct
      11.


PMID- 20937793
OWN - NLM
STAT- MEDLINE
DCOM- 20120116
LR  - 20110915
IS  - 1573-286X (Electronic)
IS  - 1079-0632 (Linking)
VI  - 23
IP  - 3
DP  - 2011 Sep
TI  - The treatment of sex offenders: evidence, ethics, and human rights.
PG  - 295-313
LID - 10.1177/1079063210381412 [doi]
AB  - Public policy is necessarily a political process with the law and order issue
      high on the political agenda. Consequently, working with sex offenders is fraught
      with legal and ethical minefields, including the mandate that community
      protection automatically outweighs offender rights. In addressing community
      protection, contemporary sex offender treatment is based on management rather
      than rehabilitation. We argue that treatment-as-management violates offender
      rights because it is ineffective and unethical. The suggested alternative is to
      deliver treatment-as-rehabilitation underpinned by international human rights law
      and universal professional ethics. An effective and ethical community-offender
      balance is more likely when sex offenders are treated with respect and dignity
      that, as human beings, they have a right to claim.
FAU - Birgden, Astrid
AU  - Birgden A
AD  - Deakin University, Melbourne, Victoria, Australia. astrid99@hotmail.com
FAU - Cucolo, Heather
AU  - Cucolo H
LA  - eng
PT  - Journal Article
DEP - 20101011
PL  - United States
TA  - Sex Abuse
JT  - Sexual abuse : a journal of research and treatment
JID - 9506704
SB  - IM
MH  - Criminals/*legislation & jurisprudence
MH  - Human Rights/*legislation & jurisprudence
MH  - Humans
MH  - *Morals
MH  - Public Policy/*legislation & jurisprudence
MH  - Sex Offenses/ethics/legislation & jurisprudence/*prevention & control
MH  - Value of Life
EDAT- 2010/10/13 06:00
MHDA- 2012/01/17 06:00
CRDT- 2010/10/13 06:00
PHST- 2010/10/13 06:00 [entrez]
PHST- 2010/10/13 06:00 [pubmed]
PHST- 2012/01/17 06:00 [medline]
AID - 1079063210381412 [pii]
AID - 10.1177/1079063210381412 [doi]
PST - ppublish
SO  - Sex Abuse. 2011 Sep;23(3):295-313. doi: 10.1177/1079063210381412. Epub 2010 Oct
      11.


PMID- 20936676
OWN - NLM
STAT- MEDLINE
DCOM- 20110407
LR  - 20101011
IS  - 1520-6696 (Electronic)
IS  - 0022-5061 (Linking)
VI  - 46
IP  - 4
DP  - 2010 Fall
TI  - The science of ethics: Deception, the resilient self, and the APA code of ethics,
      1966-1973.
PG  - 337-70
LID - 10.1002/jhbs.20468 [doi]
AB  - This paper has two aims. The first is to shed light on a remarkable archival
      source, namely survey responses from thousands of American psychologists during
      the 1960s in which they described their contemporary research practices and
      discussed whether the practices were "ethical." The second aim is to examine the 
      process through which the American Psychological Association (APA) used these
      survey responses to create principles on how psychologists should treat human
      subjects. The paper focuses on debates over whether "deception" research was
      acceptable. It documents how members of the committee that wrote the principles
      refereed what was, in fact, a disagreement between two contemporary research
      orientations. The paper argues that the ethics committee ultimately built the
      model of "the resilient self" into the APA's 1973 ethics code. At the broadest
      level, the paper explores how prevailing understandings of human nature are
      written into seemingly universal and timeless codes of ethics.
CI  - (c) 2010 Wiley Periodicals, Inc.
FAU - Stark, Laura
AU  - Stark L
AD  - Program in Science in Society and Department of Sociology, Wesleyan University in
      Middletown, Connecticut, USA.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - J Hist Behav Sci
JT  - Journal of the history of the behavioral sciences
JID - 18020010R
SB  - IM
MH  - Codes of Ethics/*history
MH  - Deception
MH  - Ethics, Research/*history
MH  - History, 20th Century
MH  - Humans
MH  - Mental Disorders/history
MH  - Psychology/ethics/*history
MH  - *Research Subjects
MH  - Social Sciences/history
MH  - Societies, Scientific/ethics/*history
MH  - Trust
MH  - Truth Disclosure/*ethics
MH  - United States
EDAT- 2010/10/12 06:00
MHDA- 2011/04/08 06:00
CRDT- 2010/10/12 06:00
PHST- 2010/10/12 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2011/04/08 06:00 [medline]
AID - 10.1002/jhbs.20468 [doi]
PST - ppublish
SO  - J Hist Behav Sci. 2010 Fall;46(4):337-70. doi: 10.1002/jhbs.20468.


PMID- 20936371
OWN - NLM
STAT- MEDLINE
DCOM- 20120727
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 18
IP  - 1
DP  - 2012 Mar
TI  - Emotional engineers: toward morally responsible design.
PG  - 103-15
LID - 10.1007/s11948-010-9236-0 [doi]
AB  - Engineers are normally seen as the archetype of people who make decisions in a
      rational and quantitative way. However, technological design is not value
      neutral. The way a technology is designed determines its possibilities, which
      can, for better or for worse, have consequences for human wellbeing. This leads
      various scholars to the claim that engineers should explicitly take into account 
      ethical considerations. They are at the cradle of new technological developments 
      and can thereby influence the possible risks and benefits more directly than
      anybody else. I have argued elsewhere that emotions are an indispensable source
      of ethical insight into ethical aspects of risk. In this paper I will argue that 
      this means that engineers should also include emotional reflection into their
      work. This requires a new understanding of the competencies of engineers: they
      should not be unemotional calculators; quite the opposite, they should work to
      cultivate their moral emotions and sensitivity, in order to be engaged in morally
      responsible engineering.
CI  - (c) The Author(s) 2010. This article is published with open access at
      Springerlink.com
FAU - Roeser, Sabine
AU  - Roeser S
AD  - Philosophy Department, Faculty of Technology, Policy and Management, Delft
      University of Technology, Jaffalaan 5, 2628 BX Delft, The Netherlands.
      S.Roeser@tudelft.nl
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101009
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Emotions
MH  - Engineering/*ethics
MH  - Humans
MH  - *Moral Obligations
MH  - Professional Competence
MH  - Risk
MH  - *Social Behavior
MH  - *Social Values
MH  - Technology/*ethics
PMC - PMC3275750
EDAT- 2010/10/12 06:00
MHDA- 2012/07/28 06:00
CRDT- 2010/10/12 06:00
PHST- 2010/06/29 00:00 [received]
PHST- 2010/09/17 00:00 [accepted]
PHST- 2010/10/12 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2012/07/28 06:00 [medline]
AID - 10.1007/s11948-010-9236-0 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2012 Mar;18(1):103-15. doi: 10.1007/s11948-010-9236-0. Epub 2010 
      Oct 9.


PMID- 20935506
OWN - NLM
STAT- MEDLINE
DCOM- 20110614
LR  - 20211020
IS  - 1554-8619 (Electronic)
IS  - 1554-8600 (Linking)
VI  - 6
IP  - 10
DP  - 2010 Oct
TI  - Dengue vaccine trial guidelines and role of large-scale, post proof-of-concept
      demonstration projects in bringing a dengue vaccine to use in dengue endemic
      areas.
PG  - 802-9
AB  - In this review, we consider the issues impacting conduct and design of dengue
      vaccine trials with reference to the recently published World Health Organization
      "Guidelines for Conduct of Clinical Trials of Dengue Vaccines in Endemic Areas." 
      We discuss logistic, scientific and ethical challenges concerning evaluation and 
      introduction of dengue vaccines; these range from randomized trials that
      establish "proof of concept" of vaccine efficacy, to post-"proof of concept"
      trials, particularly demonstration projects likely to be required for licensure
      or for the introduction of an already licensed vaccine into public use. We
      clarify and define the meaning of "proof of concept" in the clinical trial
      context and the meaning of terms "phase 2b", "phase 3b" and "demonstration
      project", which are commonly used but have not been defined well in the clinical 
      literature.
FAU - Letson, G William
AU  - Letson GW
AD  - Pediatric Dengue Vaccine Initiative, International Vaccine Institute, Seoul,
      Korea. bletson@pdvi.org
FAU - Singhasivanon, Pratap
AU  - Singhasivanon P
FAU - Fernandez, Eduardo
AU  - Fernandez E
FAU - Abeysinghe, Nihal
AU  - Abeysinghe N
FAU - Amador, Juan Jose
AU  - Amador JJ
FAU - Margolis, Harold S
AU  - Margolis HS
FAU - Edelman, Robert
AU  - Edelman R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20101001
PL  - United States
TA  - Hum Vaccin
JT  - Human vaccines
JID - 101265291
RN  - 0 (Dengue Vaccines)
SB  - IM
MH  - *Clinical Trials as Topic
MH  - Dengue/*epidemiology/*prevention & control
MH  - Dengue Vaccines/administration & dosage/adverse effects/*immunology
MH  - Guidelines as Topic
MH  - Humans
MH  - Vaccination/*statistics & numerical data
PMC - PMC3056064
EDAT- 2010/10/12 06:00
MHDA- 2011/06/15 06:00
CRDT- 2010/10/12 06:00
PHST- 2010/10/12 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2011/06/15 06:00 [medline]
AID - 13018 [pii]
AID - 10.4161/hv.6.10.13018 [doi]
PST - ppublish
SO  - Hum Vaccin. 2010 Oct;6(10):802-9. doi: 10.4161/hv.6.10.13018. Epub 2010 Oct 1.


PMID- 20935316
OWN - NLM
STAT- MEDLINE
DCOM- 20110225
LR  - 20211020
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 11
DP  - 2010 Nov
TI  - Synthetic biology and the ethics of knowledge.
PG  - 687-93
LID - 10.1136/jme.2010.038232 [doi]
AB  - Synthetic biologists aim to generate biological organisms according to rational
      design principles. Their work may have many beneficial applications, but it also 
      raises potentially serious ethical concerns. In this article, we consider what
      attention the discipline demands from bioethicists. We argue that the most
      important issue for ethicists to examine is the risk that knowledge from
      synthetic biology will be misused, for example, in biological terrorism or
      warfare. To adequately address this concern, bioethics will need to broaden its
      scope, contemplating not just the means by which scientific knowledge is
      produced, but also what kinds of knowledge should be sought and disseminated.
FAU - Douglas, Thomas
AU  - Douglas T
AD  - Oxford Uehiro Centre for Practical Ethics, Faculty of Philosophy, University of
      Oxford, Oxford, UK. thomas.douglas@philosophy.ox.ac.uk
FAU - Savulescu, Julian
AU  - Savulescu J
LA  - eng
GR  - 086015/Wellcome Trust/United Kingdom
GR  - 086041/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101008
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
CIN - J Med Ethics. 2012 Oct;38(10):636-8. PMID: 22763004
MH  - *Bioethical Issues
MH  - Biotechnology/*ethics
MH  - Humans
MH  - *Knowledge
MH  - Malpractice
PMC - PMC3045879
MID - UKMS34445
OID - NLM: UKMS34445
EDAT- 2010/10/12 06:00
MHDA- 2011/02/26 06:00
CRDT- 2010/10/12 06:00
PHST- 2010/10/12 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2011/02/26 06:00 [medline]
AID - jme.2010.038232 [pii]
AID - 10.1136/jme.2010.038232 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Nov;36(11):687-93. doi: 10.1136/jme.2010.038232. Epub 2010 Oct
      8.


PMID- 20935314
OWN - NLM
STAT- MEDLINE
DCOM- 20110315
LR  - 20101129
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 12
DP  - 2010 Dec
TI  - Regulation of treatment of infants at the edge of viability in Italy: the role of
      the medical profession?
PG  - 795-7
LID - 10.1136/jme.2010.036038 [doi]
AB  - In the last few years there has been intense debate in Italy on administration of
      life-prolonging treatment to premature babies at the edge of viability. In 2006, 
      a group of experts based in Florence drafted recommendations known as Carta di
      Firenze (CdF) for responsible use of intensive care for premature infants between
      22 and 25&emsp14;weeks of gestational age (GA). The CdF was later endorsed by
      several medicoprofessional associations, but was followed by recommendations by
      the Ministry of Health mandating resuscitation for all premature babies
      regardless of GA and parental consent. Recent statements from medicoprofessional 
      bodies seem to show that the 'always resuscitate rule' is not supported by many
      Italian doctors. We argue that ethically sensitive issues in medicine should be
      regulated with, and not against, the medical profession and its representative
      bodies.
FAU - Pignotti, Maria Serenella
AU  - Pignotti MS
AD  - Neonatal Intensive Care Unit, Anna Meyer Children's Hospital, University of
      Florence, Viale Pieraccini 24, 50100 Florence, Italy. m.pignotti@meyer.it
FAU - Moratti, Sofia
AU  - Moratti S
LA  - eng
PT  - Journal Article
DEP - 20101008
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Attitude of Health Personnel
MH  - Decision Making
MH  - *Fetal Viability
MH  - Humans
MH  - Infant, Newborn
MH  - *Infant, Premature
MH  - Intensive Care, Neonatal/*ethics/*legislation & jurisprudence
MH  - Italy
MH  - Parents
MH  - *Physician's Role
MH  - Resuscitation/ethics
EDAT- 2010/10/12 06:00
MHDA- 2011/03/16 06:00
CRDT- 2010/10/12 06:00
PHST- 2010/10/12 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2011/03/16 06:00 [medline]
AID - jme.2010.036038 [pii]
AID - 10.1136/jme.2010.036038 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Dec;36(12):795-7. doi: 10.1136/jme.2010.036038. Epub 2010 Oct 
      8.


PMID- 20935313
OWN - NLM
STAT- MEDLINE
DCOM- 20110315
LR  - 20151119
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 12
DP  - 2010 Dec
TI  - Physical therapy students' willingness to report misconduct to protect the
      patient's interests.
PG  - 802-5
LID - 10.1136/jme.2010.036046 [doi]
AB  - This article presents a study on the ethical dilemma of whistleblowing in
      physical therapy, and suggests some lines for further research on this topic as
      well as ways for integrating it in the physical therapy curriculum. The study
      examines the self-reported willingness of physical therapy students to report
      misconduct, whether internally or externally, to protect the patient's interests.
      Internal disclosure entails reporting the wrongdoing to an authority within the
      organisation. External disclosure entails reporting the offence to an outside
      agency, such as the police, professional organisation, or press. The findings
      indicate that the students view the acts that are detrimental or cause injustice 
      to the patient in a very serious light. In dilemma situations such as these, the 
      students reported a willingness to act. The students also report considerably
      greater likelihood of whistleblowing internally than externally. The pattern
      reveals a desire to correct the misconduct coupled with a marked decline in the
      willingness to blow the whistle as this act moved from the workplace to an
      external authority.
FAU - Mansbach, Abraham
AU  - Mansbach A
AD  - Department of Philosophy, Ben-Gurion University of the Negev, POB 653, Beer-Sheva
      84105, Israel. mansbach@bgu.ac.il
FAU - Bachner, Yaacov G
AU  - Bachner YG
FAU - Melzer, Itzik
AU  - Melzer I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101008
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Female
MH  - Humans
MH  - Interpersonal Relations
MH  - Male
MH  - Patient Rights
MH  - Physical Therapy Modalities/*ethics
MH  - *Professional Misconduct
MH  - Students, Medical/*psychology
MH  - Surveys and Questionnaires
MH  - Whistleblowing/*ethics
MH  - Workplace
MH  - Young Adult
EDAT- 2010/10/12 06:00
MHDA- 2011/03/16 06:00
CRDT- 2010/10/12 06:00
PHST- 2010/10/12 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2011/03/16 06:00 [medline]
AID - jme.2010.036046 [pii]
AID - 10.1136/jme.2010.036046 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Dec;36(12):802-5. doi: 10.1136/jme.2010.036046. Epub 2010 Oct 
      8.


PMID- 20935078
OWN - NLM
STAT- MEDLINE
DCOM- 20110110
LR  - 20101118
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 257
IP  - 3
DP  - 2010 Dec
TI  - Amnesia following herpes simplex encephalitis: diffusion-tensor imaging uncovers 
      reduced integrity of normal-appearing white matter.
PG  - 774-81
LID - 10.1148/radiol.10100179 [doi]
AB  - PURPOSE: To explore white matter (WM) and gray matter tissue integrity in the
      apparently unaffected hemisphere of patients with herpes simplex encephalitis
      (HSE) who have gross unilateral medial temporal lobe (MTL) lesions and both
      verbal and visuospatial memory deficits. MATERIALS AND METHODS: This study had
      institutional ethics committee approval and included written informed consent.
      Magnetic resonance (MR) imaging was performed in five patients who had recovered 
      from HSE (one woman, four men; median age, 32 years; interquartile range, 28.5-37
      years) and 51 age-matched controls (30 women, 21 men; median age, 32 years;
      interquartile range, 28-37 years). As markers of microstructural WM integrity,
      fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity, and radial 
      diffusivity (RD) derived from diffusion-tensor (DT) imaging were used. An
      automated regional brain segmentation approach yielded estimates of subcortical
      volumes, including hippocampus, and cortical thickness. Group differences were
      evaluated by using permutation tests. RESULTS: Examination of standard MR images 
      found unilateral lesions in all patients. The patients with HSE showed reduced FA
      and increased MD and RD in several WM tracts contralateral to lesions (P < .05,
      corrected for multiple comparisons). Affected tracts included connections between
      the MTLs and other parts of the brain. No significant group differences were
      observed in subcortical volume or cortical thickness. CONCLUSION: These results
      suggest that patients with HSE have reduced microstructural integrity of
      normal-appearing WM contralateral to grossly visible lesions. These subtle
      lesions, detectable at DT imaging, probably contribute to the memory impairment
      manifested by these patients. SUPPLEMENTAL MATERIAL:
      http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.10100179/-/DC1.
CI  - (c) RSNA, 2010
FAU - Grydeland, Hakon
AU  - Grydeland H
AD  - Center for the Study of Human Cognition, Department of Psychology, University of 
      Oslo, PO Box 1094, Blindern, 0317 Oslo, Norway. hakon.grydeland@psykologi.uio.no
FAU - Walhovd, Kristine B
AU  - Walhovd KB
FAU - Westlye, Lars T
AU  - Westlye LT
FAU - Due-Tonnessen, Paulina
AU  - Due-Tonnessen P
FAU - Ormaasen, Vidar
AU  - Ormaasen V
FAU - Sundseth, Oyvind
AU  - Sundseth O
FAU - Fjell, Anders M
AU  - Fjell AM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101008
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adult
MH  - Amnesia/*etiology/*pathology
MH  - Case-Control Studies
MH  - Diffusion Tensor Imaging/*methods
MH  - Encephalitis, Herpes Simplex/*complications/*pathology
MH  - Female
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Male
MH  - Nerve Fibers, Myelinated/*pathology
MH  - Retrospective Studies
MH  - Statistics, Nonparametric
EDAT- 2010/10/12 06:00
MHDA- 2011/01/11 06:00
CRDT- 2010/10/12 06:00
PHST- 2010/10/12 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2011/01/11 06:00 [medline]
AID - radiol.10100179 [pii]
AID - 10.1148/radiol.10100179 [doi]
PST - ppublish
SO  - Radiology. 2010 Dec;257(3):774-81. doi: 10.1148/radiol.10100179. Epub 2010 Oct 8.


PMID- 20934615
OWN - NLM
STAT- MEDLINE
DCOM- 20110114
LR  - 20220410
IS  - 1879-8853 (Electronic)
IS  - 0749-0690 (Linking)
VI  - 26
IP  - 4
DP  - 2010 Nov
TI  - Preventing falls and fall-related injuries in hospitals.
PG  - 645-92
LID - 10.1016/j.cger.2010.06.005 [doi]
AB  - Falls are a widespread concern in hospitals settings, with whole hospital rates
      of between 3 and 5 falls per 1000 bed-days representing around a million
      inpatient falls occurring in the United States each year. Between 1% and 3% of
      falls in hospitals result in fracture, but even minor injuries can cause distress
      and delay rehabilitation. Risk factors most consistently found in the inpatient
      population include a history of falling, muscle weakness, agitation and
      confusion, urinary incontinence or frequency, sedative medication, and postural
      hypotension. Based on systematic reviews, recent research, and clinical and
      ethical considerations, the most appropriate approach to fall prevention in the
      hospital environment includes multifactorial interventions with multiprofessional
      input. There is also some evidence that delirium avoidance programs, reducing
      sedative and hypnotic medication, in-depth patient education, and sustained
      exercise programs may reduce falls as single interventions. There is no
      convincing evidence that hip protectors, movement alarms, or low-low beds reduce 
      falls or injury in the hospital setting. International approaches to developing
      and maintaining a fall prevention program suggest that commitment of management
      and a range of clinical and support staff is crucial to success.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Oliver, David
AU  - Oliver D
AD  - School of Community and Health Sciences, City University, London, England, UK.
      David.Oliver.1@city.ac.uk
FAU - Healey, Frances
AU  - Healey F
FAU - Haines, Terry P
AU  - Haines TP
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Geriatr Med
JT  - Clinics in geriatric medicine
JID - 8603766
SB  - IM
MH  - *Accident Prevention
MH  - Accidental Falls/*prevention & control
MH  - Aged
MH  - Attitude of Health Personnel
MH  - Environment Design
MH  - Fractures, Bone
MH  - Hospitalization
MH  - *Hospitals
MH  - Humans
MH  - *Inpatients
MH  - Patient Care Team/organization & administration
MH  - Protective Devices
MH  - Risk Factors
MH  - Risk Management/organization & administration
MH  - Safety Management/organization & administration
MH  - Wounds and Injuries/*prevention & control
EDAT- 2010/10/12 06:00
MHDA- 2011/01/15 06:00
CRDT- 2010/10/12 06:00
PHST- 2010/10/12 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2011/01/15 06:00 [medline]
AID - S0749-0690(10)00053-4 [pii]
AID - 10.1016/j.cger.2010.06.005 [doi]
PST - ppublish
SO  - Clin Geriatr Med. 2010 Nov;26(4):645-92. doi: 10.1016/j.cger.2010.06.005.


PMID- 20934213
OWN - NLM
STAT- MEDLINE
DCOM- 20101028
LR  - 20220317
IS  - 1474-547X (Electronic)
IS  - 0140-6736 (Linking)
VI  - 376
IP  - 9749
DP  - 2010 Oct 16
TI  - Ethics and end-of-life care for adults in the intensive care unit.
PG  - 1347-53
LID - 10.1016/S0140-6736(10)60143-2 [doi]
AB  - The intensive care unit (ICU) is where patients are given some of the most
      technologically advanced life-sustaining treatments, and where difficult
      decisions are made about the usefulness of such treatments. The substantial
      regional variability in these ethical decisions is a result of many factors,
      including religious and cultural beliefs. Because most critically ill patients
      lack the capacity to make decisions, family and other individuals often act as
      the surrogate decision makers, and in many regions communication between the
      clinician and family is central to decision making in the ICU. Elsewhere,
      involvement of the family is reduced and that of the physicians is increased.
      End-of-life care is associated with increased burnout and distress among
      clinicians working in the ICU. Since many deaths in the ICU are preceded by a
      decision to withhold or withdraw life support, high-quality decision making and
      end-of-life care are essential in all regions, and can improve patient and family
      outcomes, and also retention of clinicians working in the ICU. To make such a
      decision requires adequate training, good communication between the clinician and
      family, and the collaboration of a well functioning interdisciplinary team.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Curtis, J Randall
AU  - Curtis JR
AD  - Division of Pulmonary and Critical Care Medicine, Harborview Medical Center;
      University of Washington, Seattle, WA 98104-2499, USA. jrc@u.washington.edu
FAU - Vincent, Jean-Louis
AU  - Vincent JL
LA  - eng
GR  - R01NR-05226/NR/NINR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20101011
PL  - England
TA  - Lancet
JT  - Lancet (London, England)
JID - 2985213R
SB  - IM
CIN - Lancet. 2010 Oct 16;376(9749):1275-6. PMID: 20934210
MH  - Adult
MH  - Communication
MH  - Decision Making
MH  - Humans
MH  - *Intensive Care Units/ethics
MH  - Interdisciplinary Communication
MH  - Patient Admission
MH  - Professional-Family Relations
MH  - Resource Allocation
MH  - *Terminal Care/ethics
MH  - Withholding Treatment
EDAT- 2010/10/12 06:00
MHDA- 2010/10/29 06:00
CRDT- 2010/10/12 06:00
PHST- 2010/10/12 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2010/10/29 06:00 [medline]
AID - S0140-6736(10)60143-2 [pii]
AID - 10.1016/S0140-6736(10)60143-2 [doi]
PST - ppublish
SO  - Lancet. 2010 Oct 16;376(9749):1347-53. doi: 10.1016/S0140-6736(10)60143-2. Epub
      2010 Oct 11.


PMID- 20932611
OWN - NLM
STAT- MEDLINE
DCOM- 20120426
LR  - 20161125
IS  - 1532-1940 (Electronic)
IS  - 0266-4356 (Linking)
VI  - 49
IP  - 8
DP  - 2011 Dec
TI  - Clinical negligence and duty of candour.
PG  - 593-6
LID - 10.1016/j.bjoms.2010.08.011 [doi]
AB  - The Department of Health is considering imposing a legal duty of candour on
      health care providers to ensure that an apology and explanation are given to
      patients when errors occur during medical treatment. This aims to improve quality
      of care and reduce adverse events during medical treatment. We present the
      current system of clinical negligence and the future of medical ethics. We
      discuss relevant cases with regard to duty of candour, and highlight the
      existence of serious imbalances in which patients' rights and corresponding
      ethical duties of professionals predominate over the responsibilities of patients
      themselves. It is known that most adverse events arise because of multiple
      factors for which no individual should be blamed. To improve healthcare services 
      there is a need for a system in which lessons can be learnt from mistakes, and
      services can be improved in the interest of patient safety, and for transparency 
      in the broad principles on which the decisions are based within which clinical
      performance is supervised and monitored.
CI  - Copyright (c) 2010 The British Association of Oral and Maxillofacial Surgeons.
      Published by Elsevier Ltd. All rights reserved.
FAU - Shekar, Vinita
AU  - Shekar V
AD  - Queen Alexandra Hospital, Portsmouth, United Kingdom. vinita_shekar@hotmail.com
FAU - Singh, Mark
AU  - Singh M
FAU - Shekar, Kishore
AU  - Shekar K
FAU - Brennan, Peter
AU  - Brennan P
LA  - eng
PT  - Journal Article
DEP - 20101006
PL  - Scotland
TA  - Br J Oral Maxillofac Surg
JT  - The British journal of oral & maxillofacial surgery
JID - 8405235
SB  - IM
MH  - *Ethics, Dental
MH  - Humans
MH  - Malpractice/*legislation & jurisprudence
MH  - Mandatory Reporting
MH  - Moral Obligations
MH  - Patient Safety
MH  - State Dentistry/*ethics/legislation & jurisprudence
MH  - Truth Disclosure/*ethics
MH  - United Kingdom
EDAT- 2010/10/12 06:00
MHDA- 2012/04/27 06:00
CRDT- 2010/10/12 06:00
PHST- 2010/03/24 00:00 [received]
PHST- 2010/08/21 00:00 [accepted]
PHST- 2010/10/12 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2012/04/27 06:00 [medline]
AID - S0266-4356(10)00290-1 [pii]
AID - 10.1016/j.bjoms.2010.08.011 [doi]
PST - ppublish
SO  - Br J Oral Maxillofac Surg. 2011 Dec;49(8):593-6. doi:
      10.1016/j.bjoms.2010.08.011. Epub 2010 Oct 6.


PMID- 20932587
OWN - NLM
STAT- MEDLINE
DCOM- 20110314
LR  - 20101124
IS  - 1872-8464 (Electronic)
IS  - 0165-5876 (Linking)
VI  - 74
IP  - 12
DP  - 2010 Dec
TI  - Chorda tympani nerve function in children: relationship to otitis media and body 
      mass index.
PG  - 1393-6
LID - 10.1016/j.ijporl.2010.09.016 [doi]
AB  - OBJECTIVE/HYPOTHESIS: A relationship between acute otitis media and elevated body
      mass index has recently been reported. Intriguingly, it was postulated that this 
      relationship may result from altered chorda tympani nerve function impacting
      taste sensation and eating habits. We sought to test this directly by measuring
      chorda tympani nerve function in children with and without a previous history of 
      acute otitis media and to determine the relationship to body mass index. STUDY
      DESIGN: Retrospective cohort study. METHODS: Institutional research ethics board 
      approval was obtained. Study participants included 142 children (5-18 years of
      age) who were recruited from an otolaryngology outpatient clinic at a tertiary
      academic pediatric hospital between May and August 2009. Children were excluded
      if they were not able to communicate effectively, younger than age 5, or had
      developmental disabilities. Body mass index was calculated and the history of
      previous otologic disease carefully elicited from the caregivers.
      Electrogustometric threshold, a validated measure of chorda tympani function, was
      obtained bilaterally in each child. Children were divided into cohorts based on
      the number of acute otitis media episodes, and electrogustometry thresholds were 
      compared between cohorts. RESULTS: Electrogustometric thresholds were
      successfully obtained in all children. There was no significant relationship
      between chorda tympani nerve function and history of acute otitis media.
      Similarly, there was no significant association between the history of otitis
      media and body mass index. CONCLUSION: This study did not demonstrate any effect 
      of previous acute otitis media history on chorda tympani nerve function.
      Furthermore, it did not demonstrate a relationship between acute otitis media and
      elevated body mass index. This is counter-evidence to the previous hypothesis
      that increasing acute otitis media is responsible for increasing childhood
      obesity through alteration in chorda tympani nerve function.
CI  - Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Seaberg, Raewyn M
AU  - Seaberg RM
AD  - Department of Otolaryngology-Head and Neck Surgery, Hospital for Sick Children,
      University of Toronto, Toronto, Ontario, Canada. raewyn.seaberg@utoronto.ca
FAU - Chadha, Neil K
AU  - Chadha NK
FAU - Hubbard, Bradley J
AU  - Hubbard BJ
FAU - Gordon, Karen A
AU  - Gordon KA
FAU - Allemang, Brooke A
AU  - Allemang BA
FAU - Harrison, Brittany J
AU  - Harrison BJ
FAU - Papsin, Blake C
AU  - Papsin BC
LA  - eng
PT  - Journal Article
DEP - 20101006
PL  - Ireland
TA  - Int J Pediatr Otorhinolaryngol
JT  - International journal of pediatric otorhinolaryngology
JID - 8003603
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - *Body Mass Index
MH  - Child
MH  - Child, Preschool
MH  - Chorda Tympani Nerve/*physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Obesity/complications
MH  - Otitis Media/complications/*physiopathology
MH  - *Taste Threshold
EDAT- 2010/10/12 06:00
MHDA- 2011/03/15 06:00
CRDT- 2010/10/12 06:00
PHST- 2010/08/10 00:00 [received]
PHST- 2010/08/29 00:00 [revised]
PHST- 2010/09/14 00:00 [accepted]
PHST- 2010/10/12 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2011/03/15 06:00 [medline]
AID - S0165-5876(10)00430-1 [pii]
AID - 10.1016/j.ijporl.2010.09.016 [doi]
PST - ppublish
SO  - Int J Pediatr Otorhinolaryngol. 2010 Dec;74(12):1393-6. doi:
      10.1016/j.ijporl.2010.09.016. Epub 2010 Oct 6.


PMID- 20932517
OWN - NLM
STAT- MEDLINE
DCOM- 20110330
LR  - 20101101
IS  - 1578-1860 (Electronic)
IS  - 0014-2565 (Linking)
VI  - 210
IP  - 10
DP  - 2010 Nov
TI  - [Legibility of the patient information sheet after its review by the clinical
      research ethics committees].
PG  - 529-30
LID - 10.1016/j.rce.2010.04.023 [doi]
FAU - Dal-Re, R
AU  - Dal-Re R
FAU - Luque-Montoro, I
AU  - Luque-Montoro I
FAU - Morejon-Bosch, E
AU  - Morejon-Bosch E
LA  - spa
PT  - Letter
TT  - Legibilidad de la hoja de informacion para el paciente tras su revision por los
      comites eticos de investigacion clinica.
DEP - 20101006
PL  - Spain
TA  - Rev Clin Esp
JT  - Revista clinica espanola
JID - 8608576
SB  - IM
MH  - *Ethics Committees, Research
MH  - Medical Records/*standards
MH  - Reading
EDAT- 2010/10/12 06:00
MHDA- 2011/03/31 06:00
CRDT- 2010/10/12 06:00
PHST- 2010/04/01 00:00 [received]
PHST- 2010/04/26 00:00 [accepted]
PHST- 2010/10/12 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2011/03/31 06:00 [medline]
AID - S0014-2565(10)00350-4 [pii]
AID - 10.1016/j.rce.2010.04.023 [doi]
PST - ppublish
SO  - Rev Clin Esp. 2010 Nov;210(10):529-30. doi: 10.1016/j.rce.2010.04.023. Epub 2010 
      Oct 6.


PMID- 20932398
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20211020
IS  - 1818-6300 (Print)
IS  - 1818-6300 (Linking)
VI  - 11
IP  - 5
DP  - 2010 Oct
TI  - Dental caries prevalence in children with cleft lip/palate aged between 6 months 
      and 6 years in the West of Scotland.
PG  - 236-41
AB  - AIM: To compare the prevalence of dental caries in children with cleft lip/palate
      with national data at the same age. METHOD: Ethical approval was granted from the
      West of Scotland Ethics Committee. Children attending the Oral Orthopaedic Clinic
      were examined for caries according to the criteria of the British Association for
      the Study of Community Dentistry (BASCD) by two trained and calibrated examiners 
      (KB, RW). Subjects were divided into five age groups: 0.5-1.49; 1.5-2.49;
      2.5-3.49; 3.5-4.49 and 4.5-6.0 years. Mean dmft scores were compared with
      available national data (National Dental Inspection Program of Scotland) for
      nursery [NDIP 3-year-old survey 2008, unpublished] and 5-year-old children in
      Scotland [NDIP, 2008]. RESULTS: 209 subjects were examined (participation rate of
      87.4%); 45.9% were female, 54.1% male; 21 children (10%) had a recognised
      syndrome and were reported separately. Cleft Palate (CP) was the most commonly
      occurring cleft in both syndromic and non-syndromic groups, followed in
      decreasing numbers by Unilateral Cleft Lip and Palate (UCLP), Bilateral Cleft Lip
      and Palate (BCLP), Unilateral Cleft Lip (UCL) and Bilateral Cleft Lip (BCL). The 
      only age group with a significantly higher level of dental caries compared with
      national data was the 4.5-6.0 year-olds where only 37.2% of the children with
      clefts were caries free compared with the national figure of 57.7% (p=0.004).
      This same age group had a mean dmft for the cleft group of 3.24 compared with
      1.86 nationally. The other age groups had similar dmft and percentages of
      subjects caries free compared with the national data. The differences did not
      reach significance. Caries was more common in the anterior teeth of the youngest 
      two age groups, but in the posterior teeth of the two oldest age groups.
      CONCLUSION: By the age of 4.5 years, children with cleft lip/palate in the West
      of Scotland have significantly more caries than their non-cleft peers.
FAU - Britton, K F M
AU  - Britton KF
AD  - Department of Paediatric Dentistry, Glasgow Dental Hospital and School, 378
      Sauchiehall Street, Glasgow, Scotland, G2 3JZ.
FAU - Welbury, R R
AU  - Welbury RR
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Eur Arch Paediatr Dent
JT  - European archives of paediatric dentistry : official journal of the European
      Academy of Paediatric Dentistry
JID - 101277157
SB  - IM
MH  - Age Factors
MH  - Child
MH  - Child, Preschool
MH  - Cleft Lip/*epidemiology
MH  - Cleft Palate/*epidemiology
MH  - DMF Index
MH  - Dental Caries/*epidemiology
MH  - Dental Restoration, Permanent/statistics & numerical data
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Prevalence
MH  - Scotland/epidemiology
MH  - Social Class
MH  - Tooth Loss/epidemiology
MH  - Vulnerable Populations/statistics & numerical data
EDAT- 2010/10/12 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/10/12 06:00
PHST- 2010/10/12 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - 10.35 [pii]
AID - 10.1007/BF03262754 [doi]
PST - ppublish
SO  - Eur Arch Paediatr Dent. 2010 Oct;11(5):236-41. doi: 10.1007/BF03262754.


PMID- 20932200
OWN - NLM
STAT- MEDLINE
DCOM- 20110121
LR  - 20101011
IS  - 1440-1614 (Electronic)
IS  - 0004-8674 (Linking)
VI  - 44
IP  - 10
DP  - 2010 Oct
TI  - Young rural people at risk for schizophrenia: time for mental health services to 
      translate research evidence into best practice of care.
PG  - 872-82
LID - 10.3109/00048674.2010.493857 [doi]
AB  - Early intervention into prodromal schizophrenia has shown promise, but
      controversy continues regarding the ethical acceptability of identifying a group 
      of 'ultra high risk' individuals of whom only 30 to 50% will develop a psychotic 
      disorder. With well developed early intervention services this group faces the
      possibility of being labelled as 'pre-psychotic', a condition for which the well 
      known stigma associated with the diagnosis of schizophrenia or bipolar disorder
      is likely to be associated. In addition, the use of potent antipsychotic and
      other medications (albeit usually at lower doses than those used for those with
      manifest psychosis) mandates consideration of the risks associated with their use
      and neurological and metabolic side effects. The potential for iatrogenic
      morbidity in the 'false positive' group must be weighed against the need of the
      'true positives' identified through screening and assessment. Current evidence
      for the concept of 'at-risk mental state' was reviewed within a
      neurodevelopmental framework, including emerging data on the effectiveness of
      early intervention for the purpose of providing recommendations for community
      mental health services. The review suggests that different treatment strategies
      may be appropriate depending on the clinical stage of the condition as long as
      the benefits of intervention outweigh its risk burden. It further suggests that
      the severity of psychoses and the evidence of its early onset in utero and its
      acceleration in adolescence positions 'ultra high risk' intervention as a core
      model for early intervention for young people by teasing apart the symptomatic
      components of the 'prepsychotic state' and ensuring the population is reaching
      targeted mental health services for screening. The model is not restricted to the
      delivery of intervention for 'pre-psychotic' young people but is applicable for
      targeted programmes for a number of clinical groups considered at 'ultra high
      risk'. However, only further research in naturalistic populations embedded in
      clinical practice and ideally conducted in partnership of mental health services 
      with academic research institutions will help clarify potential risks of early
      identification and intervention and assist in updating and making more explicit
      the clinical guidelines services will use in approaching those in the 'ultra high
      risk' group.
FAU - Stain, Helen J
AU  - Stain HJ
AD  - Centre for Rural and Remote Mental Health, University of Newcastle, Orange, New
      South Wales, Australia. Helen.Stain@newcastle.edu.au
FAU - Clark, Scott
AU  - Clark S
FAU - O'Donnell, Maryanne
AU  - O'Donnell M
FAU - Schall, Ulrich
AU  - Schall U
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Aust N Z J Psychiatry
JT  - The Australian and New Zealand journal of psychiatry
JID - 0111052
SB  - IM
MH  - Adult
MH  - Early Diagnosis
MH  - Humans
MH  - *Mental Health Services
MH  - Practice Guidelines as Topic
MH  - Risk
MH  - *Rural Population
MH  - Schizophrenia/diagnosis/*therapy
EDAT- 2010/10/12 06:00
MHDA- 2011/01/22 06:00
CRDT- 2010/10/12 06:00
PHST- 2010/10/12 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2011/01/22 06:00 [medline]
AID - 10.3109/00048674.2010.493857 [doi]
PST - ppublish
SO  - Aust N Z J Psychiatry. 2010 Oct;44(10):872-82. doi: 10.3109/00048674.2010.493857.


PMID- 20932092
OWN - NLM
STAT- MEDLINE
DCOM- 20110310
LR  - 20110202
IS  - 1933-0693 (Electronic)
IS  - 0022-3085 (Linking)
VI  - 114
IP  - 2
DP  - 2011 Feb
TI  - Dr. Henry Head and lessons learned from his self-experiment on radial nerve
      transection.
PG  - 529-33
LID - 10.3171/2010.8.JNS10400 [doi]
AB  - In this paper the authors aim to review Dr. Henry Head's famous and dramatic
      nerve sectioning experiment. They discuss the implications of his experimental
      approach as well as the effect his experiment had on the field of neurology.
      Henry Head was a prominent British neurologist who contributed greatly to the
      understanding of the sensory examination through an experiment in which he had
      his own radial nerve transected. Head carefully documented the sensory changes
      following the sectioning. He hypothesized the existence of two separate sensory
      systems: protopathic and epicritic. Head was one of the first scientists to
      speculate on sensory dissociation, and his writings generated both enthusiasm and
      controversy. Although the ethical issue of self-experimentation was raised by his
      bold experiment and many aspects of his investigations and conclusions have been 
      criticized, Head undoubtedly contributed important clinical lessons to neurology.
      Arguably, Henry Head's greatest contribution was the realization that the
      neurological portion of the sensory examination was anything but straightforward.
FAU - Lenfest, Stephen M
AU  - Lenfest SM
AD  - Department of Neurology, University of Florida Movement Disorders Center,
      Gainesville, Florida 32610, USA.
FAU - Vaduva-Nemes, Andreea
AU  - Vaduva-Nemes A
FAU - Okun, Michael S
AU  - Okun MS
LA  - eng
PT  - Biography
PT  - Historical Article
PT  - Journal Article
DEP - 20101008
PL  - United States
TA  - J Neurosurg
JT  - Journal of neurosurgery
JID - 0253357
SB  - IM
MH  - Autoexperimentation/history
MH  - England
MH  - History, 20th Century
MH  - Humans
MH  - Neurology/*history
MH  - Radial Nerve/*physiology
PS  - Head H
FPS - Head, Henry
EDAT- 2010/10/12 06:00
MHDA- 2011/03/11 06:00
CRDT- 2010/10/12 06:00
PHST- 2010/10/12 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2011/03/11 06:00 [medline]
AID - 10.3171/2010.8.JNS10400 [doi]
PST - ppublish
SO  - J Neurosurg. 2011 Feb;114(2):529-33. doi: 10.3171/2010.8.JNS10400. Epub 2010 Oct 
      8.


PMID- 20931732
OWN - NLM
STAT- MEDLINE
DCOM- 20110211
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 38
IP  - 3
DP  - 2010 Fall
TI  - Recent case developments in health law. "Willful modulation of brain activity in 
      disorders of consciousness": legal and ethical ramifications.
PG  - 713-6
FAU - Bressman, Jeremy O
AU  - Bressman JO
AD  - Harvard Law and Health Care Society, Harvard Law School.
FAU - Reidler, Jay S
AU  - Reidler JS
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - *Awareness
MH  - Consciousness Disorders/diagnosis/*psychology
MH  - Humans
MH  - Informed Consent/ethics/legislation & jurisprudence
MH  - *Magnetic Resonance Imaging
MH  - Mental Competency/*legislation & jurisprudence/standards
MH  - Persistent Vegetative State/diagnosis/*psychology
MH  - United States
MH  - Withholding Treatment/ethics/legislation & jurisprudence
EDAT- 2010/10/12 06:00
MHDA- 2011/02/12 06:00
CRDT- 2010/10/12 06:00
PHST- 2010/10/12 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2011/02/12 06:00 [medline]
PST - ppublish
SO  - J Law Med Ethics. 2010 Fall;38(3):713-6.


PMID- 20931167
OWN - NLM
STAT- MEDLINE
DCOM- 20110803
LR  - 20101008
IS  - 1972-6007 (Electronic)
IS  - 0009-9074 (Linking)
VI  - 161
IP  - 4
DP  - 2010
TI  - Observational protocol.
PG  - 401-2
AB  - An observational study (OS) is a non-interventional/non-experimental survey. In
      the OSs, the investigator observes and evaluates results of ongoing medical care 
      without 'controlling' the therapy beyond normal medical practice. An OS is aimed:
      1. to the evaluation of the safety profile of any medical procedure (drug,
      device, surgical procedure, radiotherapy, diagnostics, etc.) under the normal
      conditions of use and on great numbers of patients, 2. for close examinations on 
      the effectiveness in the clinical practice, 3. for the verification of the
      prescriptive appropriateness and 4. for pharmacoeconomic evaluations. For their
      characteristics OPs don't involve additional risks for the patients to which the 
      best conditions of clinical assistance are offered. Consequently they do not need
      further or different ethical procedures/ requirements in comparison to the
      experimental clinical studies Particularly it is necessary to avoid that an
      interventional trial could be introduced as an OP.
FAU - Sacchini, D
AU  - Sacchini D
AD  - Institute of Bioethics, A. Gemelli School of Medicine, Universita Cattolica del
      Sacro Cuore, Rome, Italy.
FAU - Pennacchini, M
AU  - Pennacchini M
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Clin Ter
JT  - La Clinica terapeutica
JID - 0372604
SB  - IM
MH  - *Observation
MH  - Research Design/standards
MH  - Terminology as Topic
EDAT- 2010/10/12 06:00
MHDA- 2011/08/04 06:00
CRDT- 2010/10/09 06:00
PHST- 2010/10/09 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
PST - ppublish
SO  - Clin Ter. 2010;161(4):401-2.


PMID- 20931162
OWN - NLM
STAT- MEDLINE
DCOM- 20110803
LR  - 20201209
IS  - 1972-6007 (Electronic)
IS  - 0009-9074 (Linking)
VI  - 161
IP  - 4
DP  - 2010
TI  - Clinical trials with mentally disabled subjects: ethical issues in national and
      international documents.
PG  - 365-73
AB  - This article summarises the key ethical considerations involved in performing
      clinical trials involving persons who cannot conscious, free and informed
      consensus. Criteria are considered, which are drawn from ethical codes,
      declarations, treaties, conventions, regulations and other documents and
      published by national, international, and supranational institutions and
      authorities. The article focuses on the evolution of attitudes regarding the
      evolution of participation of incapacitate people in clinical research--from
      their almost complete exclusion in the mid-twentieth century, partly because of
      serious historical violations of human rights, to a gradually acceptance that
      these "vulnerable" people could be involved in trials, provided that certain
      conditions were met. In particular, the problem of including incapacitated people
      in clinical trials during emergencies is also addressed.
FAU - Petrini, C
AU  - Petrini C
AD  - Bioethics Unit, Office of the President, National Institute of Health (Istituto
      Superiore di Sanita), Rome, Italy. carlo.petrini@iss.it
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - Clin Ter
JT  - La Clinica terapeutica
JID - 0372604
SB  - IM
MH  - Clinical Trials as Topic/*ethics/standards
MH  - Humans
MH  - Internationality
MH  - *Persons with Mental Disabilities
EDAT- 2010/10/12 06:00
MHDA- 2011/08/04 06:00
CRDT- 2010/10/09 06:00
PHST- 2010/10/09 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
PST - ppublish
SO  - Clin Ter. 2010;161(4):365-73.


PMID- 20930334
OWN - NLM
STAT- MEDLINE
DCOM- 20110204
LR  - 20121026
IS  - 1998-3603 (Electronic)
IS  - 0970-9290 (Linking)
VI  - 21
IP  - 3
DP  - 2010 Jul-Sep
TI  - Ethical guidelines deciding the authorship.
PG  - 315
LID - 10.4103/0970-9290.70781 [doi]
FAU - Sholapurkar, Amar A
AU  - Sholapurkar AA
LA  - eng
PT  - Editorial
PL  - India
TA  - Indian J Dent Res
JT  - Indian journal of dental research : official publication of Indian Society for
      Dental Research
JID - 9202990
CIN - Indian J Dent Res. 2012 Mar-Apr;23(2):292. PMID: 22945728
MH  - *Authorship
MH  - *Ethics, Research
MH  - Guidelines as Topic
MH  - Humans
MH  - Publishing/*ethics
MH  - Research Personnel/ethics
EDAT- 2010/10/12 06:00
MHDA- 2011/02/05 06:00
CRDT- 2010/10/09 06:00
PHST- 2010/10/09 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2011/02/05 06:00 [medline]
AID - IndianJDentRes_2010_21_3_315_70781 [pii]
AID - 10.4103/0970-9290.70781 [doi]
PST - ppublish
SO  - Indian J Dent Res. 2010 Jul-Sep;21(3):315. doi: 10.4103/0970-9290.70781.


PMID- 20930251
OWN - NLM
STAT- MEDLINE
DCOM- 20110201
LR  - 20101008
IS  - 2150-4113 (Electronic)
IS  - 1079-0969 (Linking)
VI  - 12
IP  - 1
DP  - 2010 Jun 15
TI  - Informed consent: Enforcing pharmaceutical companies' obligations abroad.
PG  - 15-28
AB  - The past several years have seen an evolution in the obligations of
      pharmaceutical companies conducting clinical trials abroad. Key players, such as 
      international human rights organizations, multinational pharmaceutical companies,
      the United States government and courts, and the media, have played a significant
      role in defining these obligations. This article examines how such obligations
      have developed through the lens of past, present, and future recommendations for 
      informed consent protections. In doing so, this article suggests that, no matter 
      how robust obligations appear, they will continue to fall short of providing
      meaningful protection until they are accompanied by a substantive enforcement
      mechanism that holds multinational pharmaceutical companies accountable for their
      conduct. Issues of national sovereignty, particularly in the United States, will 
      continue to prevent meaningful enforcement by an international tribunal or
      through one universally adopted code of ethics. This article argues that, rather 
      than continuing to pursue an untenable international approach, the Alien Torts
      Statute (ATS) offers a viable enforcement mechanism, at least for US-based
      pharmaceutical companies. Recent federal appellate court precedent interpreting
      the ATS provides the mechanism for granting victims redress and enforcing
      accountability of sponsors (usually pharmaceutical companies and research and
      academic institutions) for informed consent misconduct. Substantive human rights 
      protections are vital in order to ensure that every person can realize the "right
      to health." This article concludes that by building on the federal appellate
      court's ATS analysis, which grants foreign trial participants the right to pursue
      claims of human rights violations in US courts, a mechanism can be created for
      enforcing not only substantive informed consent, but also human rights
      protections.
FAU - Lee, Stacey B
AU  - Lee SB
AD  - Johns Hopkins University Carey Business School, 100 North Charles Street,
      Baltimore, Maryland 21201, USA. staceyb.lee@jhu.edu
LA  - eng
PT  - Journal Article
DEP - 20100615
PL  - United States
TA  - Health Hum Rights
JT  - Health and human rights
JID - 9502498
SB  - IM
MH  - Drug Industry/*legislation & jurisprudence
MH  - Helsinki Declaration
MH  - Human Rights/legislation & jurisprudence
MH  - Humans
MH  - Informed Consent/*legislation & jurisprudence
MH  - International Cooperation/*legislation & jurisprudence
MH  - Liability, Legal
MH  - Social Responsibility
MH  - United States
MH  - United States Food and Drug Administration
EDAT- 2010/10/12 06:00
MHDA- 2011/02/02 06:00
CRDT- 2010/10/09 06:00
PHST- 2010/10/09 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2011/02/02 06:00 [medline]
PST - epublish
SO  - Health Hum Rights. 2010 Jun 15;12(1):15-28.


PMID- 20930250
OWN - NLM
STAT- MEDLINE
DCOM- 20110201
LR  - 20141120
IS  - 2150-4113 (Electronic)
IS  - 1079-0969 (Linking)
VI  - 12
IP  - 1
DP  - 2010 Jun 15
TI  - Our place in the world: Conceptualizing obligations beyond borders in human
      rights-based approaches to health.
PG  - 3-14
AB  - The case of Haiti's devastating earthquake and the reactions it has elicited
      sharply illustrate an array of seemingly dichotomous ways of understanding
      obligations of "international assistance and cooperation," which are taken up by 
      authors in this issue. First, there is a tension between dealing with immediate
      humanitarian needs and addressing underlying structural causes. Second, there is 
      the related dichotomy between compassion/charity and the accountability for legal
      obligations that a human rights approach to health and development demands.
      Third, within a framework for accountability, there is a tension between an
      ahistorical understanding of international responsibility - based purely on the
      self-evident need of fellow human beings - and a contextually-rooted
      accountability. Finally, the situation of Haiti begs the question of whether we
      can address immense human suffering in the world through a strongly statist model
      or whether we require a more cosmopolitan understanding of ethical and legal
      obligations across borders. Drawing on the Critical Concepts articles in this
      issue, this essay briefly explores some of these tensions, and the potential
      contributions and limitations of applying a human rights framework to advance
      global health.
FAU - Yamin, Alicia Ely
AU  - Yamin AE
AD  - Harvard Law School, USA. ayamin@law.harvard.edu
LA  - eng
PT  - Journal Article
DEP - 20100615
PL  - United States
TA  - Health Hum Rights
JT  - Health and human rights
JID - 9502498
SB  - IM
MH  - Delivery of Health Care
MH  - *Global Health
MH  - Health Services Accessibility
MH  - Health Services Needs and Demand
MH  - *Health Status Disparities
MH  - Human Rights
MH  - Humans
MH  - *International Cooperation
MH  - *Patient Rights
MH  - Poverty
MH  - Social Justice
MH  - Social Responsibility
EDAT- 2010/10/12 06:00
MHDA- 2011/02/02 06:00
CRDT- 2010/10/09 06:00
PHST- 2010/10/09 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2011/02/02 06:00 [medline]
PST - epublish
SO  - Health Hum Rights. 2010 Jun 15;12(1):3-14.


PMID- 20930241
OWN - NLM
STAT- MEDLINE
DCOM- 20101025
LR  - 20101008
IS  - 1930-7837 (Electronic)
IS  - 0022-0337 (Linking)
VI  - 74
IP  - 10
DP  - 2010 Oct
TI  - A content analysis of dental education research as reported in two journals.
PG  - 1106-12
AB  - Little systematic information has been collected about the nature and types of
      studies published in dental education journals. The goals of this study were to
      conduct a content analysis of articles published in dental education journals in 
      two recent years, describe the type of research published, identify possible
      gaps, and propose future agendas. A content analysis of articles published in two
      leading dental education journals was performed for the years 2003 and 2008 with 
      253 articles reviewed. Most articles were descriptive and observational in
      nature. Curriculum was the most common topic of study addressed. The mean number 
      of authors per article increased slightly over time, and authors held mostly a
      combination of D.D.S. and M.S. degrees or Ph.D. degrees. A review of the
      literature was present and critically discussed in almost three-quarters of the
      articles studied. One-third of the articles mentioned ethics review or approval. 
      Most of the studies were conducted in North America, followed by Europe. About
      one-third of the articles reported a source of funding. A plea is made for more
      systematic studies of the effectiveness of instructional and curricular
      innovations and more clarification studies to better understand why certain
      initiatives or interventions work or not.
FAU - Sukotjo, Cortino
AU  - Sukotjo C
AD  - Department of Restorative Dentistry, University of Illinois at Chicago, College
      of Dentistry (MC 555), 801 South Paulina Street, Chicago, IL 60612-7211, USA.
      csukotjo@uic.edu
FAU - Yuan, Judy Chia-Chun
AU  - Yuan JC
FAU - Bordage, Georges
AU  - Bordage G
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Dent Educ
JT  - Journal of dental education
JID - 8000150
SB  - IM
MH  - Canada
MH  - Conflict of Interest
MH  - Curriculum
MH  - *Dental Research
MH  - *Education, Dental
MH  - Ethical Review
MH  - Europe
MH  - Humans
MH  - *Periodicals as Topic
MH  - Research Support as Topic
MH  - United States
EDAT- 2010/10/12 06:00
MHDA- 2010/10/26 06:00
CRDT- 2010/10/09 06:00
PHST- 2010/10/09 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2010/10/26 06:00 [medline]
AID - 74/10/1106 [pii]
PST - ppublish
SO  - J Dent Educ. 2010 Oct;74(10):1106-12.


PMID- 20930180
OWN - NLM
STAT- MEDLINE
DCOM- 20110202
LR  - 20151119
IS  - 1552-6119 (Electronic)
IS  - 1077-5595 (Linking)
VI  - 15
IP  - 4
DP  - 2010 Nov
TI  - No follow-up after positive newborn screening: medical neglect?
PG  - 315-23
LID - 10.1177/1077559510384983 [doi]
AB  - The current study examined medical professionals' behaviors related to reporting 
      medical neglect when a family is noncompliant with follow-up services after a
      positive newborn screening result. Pediatric medical professionals within an
      urban medical campus were provided with five case vignettes in relation to
      different diseases. Medical professionals rated the severity of family
      noncompliance with follow-up services and indicated whether they would report
      suspected medical neglect to Child Protective Services (CPS). Physicians were
      more likely to report medical neglect than the other mandated reporters in the
      study. Logistic regression analyses found that medical professionals' perceptions
      of the severity of family noncompliance with services were significantly
      predictive of decisions to report medical neglect. Respondent gender and the
      method by which families were notified of screening results also significantly
      affected reporting behaviors in certain instances. Although all vignettes
      included information that met legal statutes for reporting neglect, medical
      professionals indicated that they would only report neglect 40-61% of the time
      across vignettes. Continued investigation of the rationale behind medical
      professionals' decision-making process and training protocols designed to improve
      mandated reporter knowledge and reporting behaviors are needed to further reduce 
      bias and improve objectivity when considering ethical and professional
      obligations to report medical neglect.
FAU - Merrick, Melissa T
AU  - Merrick MT
AD  - Department of Pediatrics, Leonard M. Miller School of Medicine, University of
      Miami, Miami, FL 33136, USA. melissamerrick@gmail.com
FAU - Butt, Sakina M
AU  - Butt SM
FAU - Jent, Jason F
AU  - Jent JF
FAU - Cano, Nicole M
AU  - Cano NM
FAU - Lambert, Walter F
AU  - Lambert WF
FAU - Chapman, Ana V
AU  - Chapman AV
FAU - Griffith, Joseph F
AU  - Griffith JF
FAU - Ciener, Daisy
AU  - Ciener D
FAU - Dandes, Susan K
AU  - Dandes SK
FAU - Sanders, Lee M
AU  - Sanders LM
LA  - eng
GR  - 5T32HD07510-08/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Child Maltreat
JT  - Child maltreatment
JID - 9602869
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Infant Welfare/*prevention & control
MH  - Infant, Newborn
MH  - Male
MH  - Malpractice
MH  - *Mandatory Reporting
MH  - Middle Aged
MH  - Neonatal Screening/*methods
MH  - Patient Compliance/*statistics & numerical data
MH  - Physician's Role
MH  - Practice Patterns, Physicians'/*statistics & numerical data
MH  - Professional-Family Relations
EDAT- 2010/10/12 06:00
MHDA- 2011/02/03 06:00
CRDT- 2010/10/09 06:00
PHST- 2010/10/09 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2011/02/03 06:00 [medline]
AID - 15/4/315 [pii]
AID - 10.1177/1077559510384983 [doi]
PST - ppublish
SO  - Child Maltreat. 2010 Nov;15(4):315-23. doi: 10.1177/1077559510384983.


PMID- 20929741
OWN - NLM
STAT- MEDLINE
DCOM- 20101102
LR  - 20161125
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Linking)
VI  - 330
IP  - 6001
DP  - 2010 Oct 8
TI  - Biomedical ethics. Guatemala study from 1940s reflects a 'dark chapter' in
      medicine.
PG  - 160
LID - 10.1126/science.330.6001.160 [doi]
FAU - Minogue, Kristen
AU  - Minogue K
FAU - Marshall, Eliot
AU  - Marshall E
LA  - eng
PT  - Historical Article
PT  - News
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
SB  - IM
MH  - *Bioethical Issues
MH  - Female
MH  - Guatemala
MH  - History, 20th Century
MH  - Humans
MH  - Male
MH  - Military Personnel/history
MH  - Nontherapeutic Human Experimentation/ethics/*history
MH  - Prisoners/history
MH  - Sex Work
MH  - Sexually Transmitted Diseases, Bacterial/drug therapy/*history
MH  - United States
MH  - United States Public Health Service/history
EDAT- 2010/10/12 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/10/09 06:00
PHST- 2010/10/09 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - 330/6001/160 [pii]
AID - 10.1126/science.330.6001.160 [doi]
PST - ppublish
SO  - Science. 2010 Oct 8;330(6001):160. doi: 10.1126/science.330.6001.160.


PMID- 20929540
OWN - NLM
STAT- MEDLINE
DCOM- 20101228
LR  - 20211020
IS  - 1532-429X (Electronic)
IS  - 1097-6647 (Linking)
VI  - 12
DP  - 2010 Oct 7
TI  - Prediction of global left ventricular functional recovery in patients with heart 
      failure undergoing surgical revascularisation, based on late gadolinium
      enhancement cardiovascular magnetic resonance.
PG  - 56
LID - 10.1186/1532-429X-12-56 [doi]
AB  - BACKGROUND: The new gold standard for myocardial viability assessment is late
      gadolinium enhancement-cardiovascular magnetic resonance (LGE-CMR); this
      technique has demonstrated that the transmural extent of scar predicts segmental 
      functional recovery. We now asked how the number of viable and number of
      viable+normal, segments predicted recovery of global left ventricular (LV)
      function in patients undergoing CABG. Finally, we examined which segmental
      transmural threshold of scarring best predicted global LV recovery. METHODS AND
      RESULTS: Fifty patients with reduced LV ejection fraction (EF) referred for CABG 
      were recruited, and 33 included in this analysis. Patients underwent CMR to
      assess LV function and viability pre-operatively at 6 days and 6 months. Mean
      LVEF 38% +/- 11, which improved to 43% +/- 12 after surgery. 21/33 patients
      improved EF by >/=3% (EF before 38% +/- 13, after 47% +/- 13), 12/33 did not (EF 
      before 39% +/- 6, after 37% +/- 8). The only independent predictor for global
      functional recovery after revascularisation was the number of viable+normal
      segments: Based on a segmental transmural viability cutoff of <50%, ROC analysis 
      demonstrated >/=10 viable+normal segments predicted >/=3% improvement in LVEF
      with a sensitivity of 95% and specificity of 75% (AUC = 0.9, p < 0.001).
      Transmural viability cutoffs of <25 and <75% and a cutoff of >/=4 viable segments
      were less useful predictors of global LV recovery. CONCLUSIONS: Based on a 50%
      transmural viability cutoff, patients with >/=10 viable+normal segments improve
      global LV function post revascularisation, while patients with fewer such
      segments do not. LGE-CMR is a simple and powerful tool for identifying which
      patients with impaired LV function will benefit from CABG. TRIAL REGISTRATION:
      Research Ethics Committee Unique Identifier: NRES:05/Q1603/42. The study is
      listed on the Current Controlled Trials Registry: ISRCTN41388968.URL:
      http://www.controlled-trials.com.
FAU - Pegg, Tammy J
AU  - Pegg TJ
AD  - University of Oxford Centre for Clinical Magnetic Resonance Research, UK.
FAU - Selvanayagam, Joseph B
AU  - Selvanayagam JB
FAU - Jennifer, Joslin
AU  - Jennifer J
FAU - Francis, Jane M
AU  - Francis JM
FAU - Karamitsos, Theodoros D
AU  - Karamitsos TD
FAU - Dall'Armellina, Erica
AU  - Dall'Armellina E
FAU - Smith, Karen L
AU  - Smith KL
FAU - Taggart, David P
AU  - Taggart DP
FAU - Neubauer, Stefan
AU  - Neubauer S
LA  - eng
SI  - ISRCTN/ISRCTN41388968
GR  - PG7 035/British Heart Foundation/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101007
PL  - England
TA  - J Cardiovasc Magn Reson
JT  - Journal of cardiovascular magnetic resonance : official journal of the Society
      for Cardiovascular Magnetic Resonance
JID - 9815616
RN  - 0 (Contrast Media)
RN  - 84F6U3J2R6 (gadodiamide)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Aged
MH  - Contrast Media
MH  - *Coronary Artery Bypass
MH  - England
MH  - Gadolinium DTPA
MH  - Heart Failure/*diagnosis/physiopathology/surgery
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - Patient Selection
MH  - Predictive Value of Tests
MH  - Randomized Controlled Trials as Topic
MH  - Recovery of Function
MH  - Stroke Volume
MH  - Time Factors
MH  - Treatment Outcome
MH  - *Ventricular Function, Left
PMC - PMC2959056
EDAT- 2010/10/12 06:00
MHDA- 2010/12/29 06:00
CRDT- 2010/10/09 06:00
PHST- 2010/06/01 00:00 [received]
PHST- 2010/10/07 00:00 [accepted]
PHST- 2010/10/09 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2010/12/29 06:00 [medline]
AID - 1532-429X-12-56 [pii]
AID - 10.1186/1532-429X-12-56 [doi]
PST - epublish
SO  - J Cardiovasc Magn Reson. 2010 Oct 7;12:56. doi: 10.1186/1532-429X-12-56.


PMID- 20929409
OWN - NLM
STAT- MEDLINE
DCOM- 20110330
LR  - 20220408
IS  - 1557-900X (Electronic)
IS  - 0892-7790 (Linking)
VI  - 24
IP  - 12
DP  - 2010 Dec
TI  - Application of ice cold irrigation during vascular pedicle control of
      robot-assisted radical prostatectomy: EnSeal instrument cooling to reduce
      collateral thermal tissue damage.
PG  - 1991-6
LID - 10.1089/end.2010.0392 [doi]
AB  - BACKGROUND AND PURPOSE: Energy-based hemostasis of the prostatic vascular
      pedicles (PVP) during robot-assisted radical prostatectomy (RARP) may cause
      collateral thermal injury to adjacent neural tissue and has been shown to
      negatively impact sexual function recovery. The unique engineering design of the 
      EnSeal((R)) (Ethicon, Cincinnati, OH) has been demonstrated to limit collateral
      thermal tissue damage to <1.0 mm. Use of tissue and instrument cooling before and
      during device activation may potentially further reduce thermal spread. As such, 
      we sought to evaluate the collateral tissue effects of EnSeal with or without
      cold saline irrigation (CSI) during PVP control. PATIENTS AND METHODS: The EnSeal
      Trio device was used for PVP control in 20 consecutive men undergoing bilateral, 
      non-nerve-sparing RARP. Ipsilateral vascular pedicles were randomly selected to
      EnSeal plus CSI (<4 degrees C) application to the tissue before and during device
      activation or EnSeal alone. The primary end point was the distance of thermal
      injury from the inked margin using both hematoxylin and eosin (H&E) and terminal 
      transferase uridyl nick end-labeling (TUNEL) apoptosis staining. A mean of three 
      measurements was taken for each pedicle. Pathologic analysis was performed by a
      single, blinded uropathologist. RESULTS: Mean distance of thermal injury from the
      inked margin using H&E staining was 0.31 mm (range 0.15-0.40 mm) and 0.98 mm
      (range 0.7-1.2 mm) for the EnSeal plus CSI and EnSeal alone, respectively (P <
      0.0001). TUNEL staining also demonstrated lateral tissue damage of 0.39 mm (range
      0.2-0.5 mm) and 1.12 mm (range 0.9-1.3 mm), respectively (P < 0.001). No
      complications related to hemostasis or postoperative bleeding were observed in
      the study. CONCLUSIONS: The hemostatic properties of EnSeal work effectively when
      submerged in CSI. Adjacent thermal tissue damage is significantly minimized with 
      the addition of CSI. This may have a beneficial impact on nerve preservation and 
      sexual function outcomes after RARP.
FAU - Zorn, Kevin C
AU  - Zorn KC
AD  - Section of Urology, University of Montreal Hospital Center, Montreal, Quebec,
      Canada. kevin.zorn@gmail.com
FAU - Bhojani, Naeem
AU  - Bhojani N
FAU - Gautam, Gagan
AU  - Gautam G
FAU - Shikanov, Sergey
AU  - Shikanov S
FAU - Gofrit, Ofer N
AU  - Gofrit ON
FAU - Jayram, Gautam
AU  - Jayram G
FAU - Katz, Mark H
AU  - Katz MH
FAU - Cagiannos, Ilias
AU  - Cagiannos I
FAU - Budaus, Lars
AU  - Budaus L
FAU - Abdollah, Firas
AU  - Abdollah F
FAU - Sun, Maxine
AU  - Sun M
FAU - Karakiewicz, Pierre I
AU  - Karakiewicz PI
FAU - Shalhav, Arieh L
AU  - Shalhav AL
FAU - Al-Ahmadie, Hikmat A
AU  - Al-Ahmadie HA
LA  - eng
PT  - Journal Article
DEP - 20101007
PL  - United States
TA  - J Endourol
JT  - Journal of endourology
JID - 8807503
RN  - 0 (Ice)
SB  - IM
MH  - Blood Vessels/*pathology
MH  - Humans
MH  - Hypothermia, Induced/*methods
MH  - *Ice
MH  - In Situ Nick-End Labeling
MH  - Male
MH  - Prostate/*blood supply/*pathology/surgery
MH  - Prostatectomy/*instrumentation
MH  - Robotics/*instrumentation
MH  - Therapeutic Irrigation
EDAT- 2010/10/12 06:00
MHDA- 2011/03/31 06:00
CRDT- 2010/10/09 06:00
PHST- 2010/10/09 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2011/03/31 06:00 [medline]
AID - 10.1089/end.2010.0392 [doi]
PST - ppublish
SO  - J Endourol. 2010 Dec;24(12):1991-6. doi: 10.1089/end.2010.0392. Epub 2010 Oct 7.


PMID- 20929275
OWN - NLM
STAT- MEDLINE
DCOM- 20110121
LR  - 20120524
IS  - 1445-6354 (Electronic)
IS  - 1445-6354 (Linking)
VI  - 10
IP  - 4
DP  - 2010 Oct-Dec
TI  - Early childhood caries among Hutterite preschool children in Manitoba, Canada.
PG  - 1535
AB  - INTRODUCTION: This study investigated the prevalence of early childhood caries
      (ECC) among Hutterite preschool children from different colonies in southwestern 
      Manitoba, Canada. METHODS: Following informed consent from the child's parent,
      children under 72 months of age underwent a dental screening examination.
      Approval was granted by the University of Manitoba's Health Research Ethics
      Board. RESULTS: A total of 66 children with a mean age of 40.1 +/- 20.1 months
      participated. The prevalence of ECC was 53%, while the mean decayed, extracted
      and filled teeth (deft) score was 2.8 +/- 4.0 (range 0-20). A total of 42.4% had 
      severe ECC (S-ECC). There was no difference in prevalence among the 6
      participating colonies. Only 15 children had already been to the dentist, with
      the majority of these visits due to decay or dental pain. Of those, the mean age 
      for a first visit was 2.7 +/- 0.6 years. Children with ECC were determined to be 
      significantly older than those who were caries-free (p<.0001). Early childhood
      caries and higher caries rates were associated with lower maternal ratings of
      their child's dental health. Both ECC and increased deft scores were
      significantly associated with the number of children in the home. CONCLUSIONS:
      This is the first study to report the prevalence of primary tooth decay in
      Hutterite children. Rates were comparable with other Canadian data for rural
      dwelling children. Effective and culturally appropriate prevention and health
      promotion activities are warranted, including fluoride varnish and early dental
      visits.
FAU - Schroth, Robert
AU  - Schroth R
AD  - University of Manitoba, Winnipeg, Manitoba, Canada. umschrot@cc.umanitoba.ca
FAU - Dahl, Pamel
AU  - Dahl P
FAU - Haque, Mohammad
AU  - Haque M
FAU - Kliewer, Eleonore
AU  - Kliewer E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101005
PL  - Australia
TA  - Rural Remote Health
JT  - Rural and remote health
JID - 101174860
SB  - IM
MH  - Age Factors
MH  - Child, Preschool
MH  - Dental Caries/*epidemiology
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Manitoba
MH  - Oral Health
MH  - *Oral Hygiene
MH  - Pilot Projects
MH  - Prevalence
MH  - Preventive Dentistry/*statistics & numerical data
MH  - *Protestantism
EDAT- 2010/10/12 06:00
MHDA- 2011/01/22 06:00
CRDT- 2010/10/09 06:00
PHST- 2010/10/09 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2011/01/22 06:00 [medline]
AID - 1535 [pii]
PST - ppublish
SO  - Rural Remote Health. 2010 Oct-Dec;10(4):1535. Epub 2010 Oct 5.


PMID- 20929116
OWN - NLM
STAT- MEDLINE
DCOM- 20101123
LR  - 20191111
IS  - 1526-9248 (Print)
IS  - 1526-9248 (Linking)
VI  - 20
IP  - 3
DP  - 2010 Sep
TI  - Probing transplant and living donor candidates about their participation in organ
      vending.
PG  - 292-5
AB  - The selling of human organs for transplant is illegal in the United States and in
      most countries; however, such transactions still occur. Transplant hospitals and 
      their personnel have multiple ethical duties, including (1) protecting the safety
      of their living donors and transplant recipients and (2) protecting the integrity
      of living donation and transplantation as clinical practices. To date, few
      psychosocial screening tools exist that pertain specifically to a person's risk
      or intent of pursuing organ vending (buying or selling). This article presents a 
      series of transplant ethics case consultations that spawned the creation of a set
      of behavioral prompts for teams to probe with regard to organ vending when
      screening candidates about their suitability for participation as living donors
      or transplant recipients.
FAU - Bramstedt, Katrina A
AU  - Bramstedt KA
AD  - California Pacific Medical Center, San Francisco, California, USA.
      txbioethics@yahoo.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Prog Transplant
JT  - Progress in transplantation (Aliso Viejo, Calif.)
JID - 100909380
MH  - Altruism
MH  - California
MH  - *Commerce/ethics/organization & administration
MH  - *Donor Selection/ethics/organization & administration
MH  - Ethics Committees, Clinical
MH  - Ethics Consultation
MH  - Humans
MH  - Kidney Transplantation/ethics/legislation & jurisprudence/*psychology
MH  - Living Donors/ethics/legislation & jurisprudence/*psychology
MH  - Patient Acceptance of Health Care/*psychology
MH  - *Tissue and Organ Procurement/ethics/organization & administration
EDAT- 2010/10/12 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/10/09 06:00
PHST- 2010/10/09 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.7182/prtr.20.3.ug552kp430516561 [doi]
PST - ppublish
SO  - Prog Transplant. 2010 Sep;20(3):292-5. doi: 10.7182/prtr.20.3.ug552kp430516561.


PMID- 20929113
OWN - NLM
STAT- MEDLINE
DCOM- 20101123
LR  - 20191111
IS  - 1526-9248 (Print)
IS  - 1526-9248 (Linking)
VI  - 20
IP  - 3
DP  - 2010 Sep
TI  - Organ transplantation in Egypt.
PG  - 274-8
AB  - Concern has increasingly been expressed about the growing number of reports of
      medical personnel participating in the transplantation of human organs or tissues
      taken from the bodies of executed prisoners, handicapped patients, or poor
      persons who have agreed to part with their organs for commercial purposes. Such
      behavior has been universally considered as ethically and morally reprehensible, 
      yet in some parts of the world the practice continues to flourish. The concept of
      justice demands that every person have an equal right to life, and to protect
      this right, society has an obligation to ensure that every person has equal
      access to medical care. Regrettably, the Egyptian system does not legally
      recognize brain death and continues to allow the buying and selling of organs.
      For more than 30 years in Egypt, the ability to pay has determined who receives
      an organ and economic need has determined who will be the donor. As transplant
      professionals, it is important that we advocate on behalf of all patients,
      potential recipients, and donors and for those who are left out and not likely to
      receive a donor organ in an economically based system. Current issues associated 
      with this debate are reviewed and recommendations about how to address them in
      Egypt are discussed.
FAU - Paris, Wayne
AU  - Paris W
AD  - Abilene Christian University, School of Social Work, Abilene, Texas 79699, USA.
      wayne.paris@acu.edu
FAU - Nour, Bakr
AU  - Nour B
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Prog Transplant
JT  - Progress in transplantation (Aliso Viejo, Calif.)
JID - 100909380
MH  - Brain Death/diagnosis/legislation & jurisprudence
MH  - Dissent and Disputes
MH  - Egypt
MH  - Health Planning Guidelines
MH  - Humans
MH  - *Organ Transplantation/ethics/legislation & jurisprudence/statistics & numerical 
      data
MH  - *Patient Rights/ethics/legislation & jurisprudence
MH  - Practice Patterns, Physicians'/ethics/organization & administration
MH  - Social Justice/ethics/legislation & jurisprudence
MH  - Social Responsibility
MH  - *Tissue and Organ Procurement/ethics/organization & administration
EDAT- 2010/10/12 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/10/09 06:00
PHST- 2010/10/09 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.7182/prtr.20.3.27q6h2h06005u620 [doi]
PST - ppublish
SO  - Prog Transplant. 2010 Sep;20(3):274-8. doi: 10.7182/prtr.20.3.27q6h2h06005u620.


PMID- 20929071
OWN - NLM
STAT- MEDLINE
DCOM- 20101029
LR  - 20101008
IS  - 0017-7768 (Print)
IS  - 0017-7768 (Linking)
VI  - 149
IP  - 5
DP  - 2010 May
TI  - [Effect of iron deficiency and iron deficiency anemia in the first two years of
      life on cognitive and mental development during childhood].
PG  - 309-14, 335
AB  - INTRODUCTION: The prevalence of iron deficiency anemia among infants and children
      over the world ranges between 2%-22.5%. Iron is essential for intact development 
      of the body, and especiaLLy for the development of the central nervous system in 
      the first two years of Life. OBJECTIVES: To examine, through a review of the
      literature, if there is any relation between iron deficiency and iron deficiency 
      anemia (IDA), and cognitive and mental development in the first two years of
      life. METHODS: A review of 10 longitudinal and clinical trials from the last 16
      years, in which this correlation was examined. RESULTS: According to recent
      studies, the relation between iron deficiency and iron deficiency anemia to
      cognitive and mental development in childhood is stiLL unclear. Followup studies 
      found poorer cognitive scores on measures of mental and cognitive functioning in 
      the long run. Intervention trials in which iron supplementation was administered 
      to infants with IDA, found an improvement in Language and mental deveLopmental
      test scores. However, micronutrient intervention, or zinc and iron combined or
      alone, did not improve performance on mental tests. The studies differed in the
      characteristics of the study population, definition of exposure, type of
      treatment and confounders. CONCLUSIONS: It is difficult to assess a causal
      relationship between iron deficiency and iron deficiency anemia, and cognitive
      and mental development in childhood, mainly due to methodoLogical and ethical
      reasons. However, most studies from recent years support a negative association. 
      The Ministry of Health in israel recommends iron as a preventive action for iron 
      deficiency in infants.
FAU - Glazer, Yael
AU  - Glazer Y
AD  - Department of Epidemiology and Health Services Evaluation, Faculty of Health
      Sciences, Ben-Gurion University of the Negev, Beer Sheba. glazer@bgu.ac.il
FAU - Bilenko, Natalya
AU  - Bilenko N
LA  - heb
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Israel
TA  - Harefuah
JT  - Harefuah
JID - 0034351
SB  - IM
MH  - Anemia, Iron-Deficiency/*complications/epidemiology/prevention & control
MH  - Child
MH  - Child, Preschool
MH  - Cognition/physiology
MH  - Cognition Disorders/*etiology
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Iron Metabolism Disorders/*complications/epidemiology/prevention & control
MH  - Mental Competency
MH  - Mental Disorders/etiology/psychology
EDAT- 2010/10/12 06:00
MHDA- 2010/10/30 06:00
CRDT- 2010/10/09 06:00
PHST- 2010/10/09 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2010/10/30 06:00 [medline]
PST - ppublish
SO  - Harefuah. 2010 May;149(5):309-14, 335.


PMID- 20928992
OWN - NLM
STAT- MEDLINE
DCOM- 20101102
LR  - 20151119
IS  - 1565-1088 (Print)
VI  - 12
IP  - 6
DP  - 2010 Jun
TI  - Attitudes of emergency department staff toward family presence during
      resuscitation.
PG  - 366-70
AB  - BACKGROUND: While family presence during resuscitation has been researched
      extensively in the international and especially American medical literature, in
      Israel this subject has rarely been researched. Because such policies have become
      common practice in many countries, it is important to investigate the attitudes
      of health care staff in Israeli emergency departments to better understand the
      potential implication of adopting such policies. OBJECTIVES: To examine the
      attitudes of the physicians and nurses in the ED of Soroka Medical Center to
      FPDR. METHODS: The methods we used were both qualitative (partly structured open 
      interviews of 10 ED staff members from various medical professions) and
      quantitative (an anonymous questionnaire that collected sociodemographic,
      professional, and attitude data). RESULTS: The qualitative and quantitative
      results showed that most staff members opposed FPDR. The main reasons for
      objecting to FPDR were concern about family criticism, the added pressure that
      would be put on the staff members, fear of lawsuits, fear of hurting the feelings
      of the families, and the danger of losing one's "objectivity" while treating
      patients. Physicians objected more strongly to FPDR than did nurses. CONCLUSIONS:
      More research is needed on FPDR in Israel, including an examination of its
      medical, ethical, legal and logistic aspects. In addition to the views of the
      medical staff, the attitudes of patients and their families should also be
      examined.
FAU - Wacht, Oren
AU  - Wacht O
AD  - Department of Health Systems Management, Faculty of Health Sciences, Ben-Gurion
      University of the Negev, Beer Sheva, Israel.
FAU - Dopelt, Keren
AU  - Dopelt K
FAU - Snir, Yoram
AU  - Snir Y
FAU - Davidovitch, Nadav
AU  - Davidovitch N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Israel
TA  - Isr Med Assoc J
JT  - The Israel Medical Association journal : IMAJ
JID - 100930740
SB  - IM
MH  - *Attitude of Health Personnel
MH  - *Cardiopulmonary Resuscitation/psychology
MH  - Emergency Service, Hospital
MH  - *Family
MH  - Humans
MH  - Nursing Staff, Hospital/psychology
MH  - Physicians/psychology
MH  - Qualitative Research
MH  - Surveys and Questionnaires
EDAT- 2010/10/12 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/10/09 06:00
PHST- 2010/10/09 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
PST - ppublish
SO  - Isr Med Assoc J. 2010 Jun;12(6):366-70.


PMID- 20928902
OWN - NLM
STAT- MEDLINE
DCOM- 20110415
LR  - 20211203
IS  - 1549-4918 (Electronic)
IS  - 1066-5099 (Linking)
VI  - 28
IP  - 12
DP  - 2010 Dec
TI  - Law, ethics, religion, and clinical translation in the 21st century--a
      conversation with Il-Hoan Oh. Interview by Majlinda Lako, Alan Trounson and Susan
      Daher.
PG  - 2121-3
LID - 10.1002/stem.536 [doi]
FAU - Oh, Il-Hoan
AU  - Oh IH
LA  - eng
PT  - Autobiography
PT  - Biography
PT  - Historical Article
PT  - Interview
PT  - Portrait
PL  - England
TA  - Stem Cells
JT  - Stem cells (Dayton, Ohio)
JID - 9304532
SB  - IM
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - *Legislation as Topic
MH  - *Religion
MH  - Republic of Korea
MH  - Stem Cell Research
MH  - Translational Research, Biomedical/*ethics/*history/legislation & jurisprudence
PS  - Oh I
FPS - Oh, Il-Hoan
EDAT- 2010/10/12 06:00
MHDA- 2011/04/19 06:00
CRDT- 2010/10/08 06:00
PHST- 2010/10/08 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2011/04/19 06:00 [medline]
AID - 10.1002/stem.536 [doi]
PST - ppublish
SO  - Stem Cells. 2010 Dec;28(12):2121-3. doi: 10.1002/stem.536.


PMID- 20927413
OWN - NLM
STAT- MEDLINE
DCOM- 20110118
LR  - 20211020
IS  - 1549-1676 (Electronic)
IS  - 1549-1277 (Linking)
VI  - 7
IP  - 9
DP  - 2010 Sep 28
TI  - Are drug companies living up to their human rights responsibilities? The
      perspective of the former United Nations Special Rapporteur (2002-2008).
PG  - e1000330
LID - 10.1371/journal.pmed.1000330 [doi]
LID - e1000330 [pii]
AB  - BACKGROUND TO THE DEBATE: The human rights responsibilities of drug companies
      have been considered for years by nongovernmental organizations, but were most
      sharply defined in a report by the UN Special Rapporteur on the right to health, 
      submitted to the United Nations General Assembly in August 2008. The "Human
      Rights Guidelines for Pharmaceutical Companies in relation to Access to
      Medicines" include responsibilities for transparency, management, monitoring and 
      accountability, pricing, and ethical marketing, and against lobbying for more
      protection in intellectual property laws, applying for patents for trivial
      modifications of existing medicines, inappropriate drug promotion, and excessive 
      pricing. Two years after the release of the Guidelines, the PLoS Medicine Debate 
      asks whether drug companies are living up to their human rights responsibilities.
      Sofia Gruskin and Zyde Raad from the Harvard School of Public Health say more
      assessment is needed of such responsibilities; Geralyn Ritter, Vice President of 
      Global Public Policy and Corporate Responsibility at Merck & Co. argues that
      multiple stakeholders could do more to help States deliver the right to health;
      and Paul Hunt and Rajat Khosla introduce Mr. Hunt's work as the UN Special
      Rapporteur on the right to the highest attainable standard of health, regarding
      the human rights responsibilities of pharmaceutical companies and access to
      medicines.
FAU - Hunt, Paul
AU  - Hunt P
AD  - Human Rights Centre, Department of Law, University of Essex, Essex, United
      Kingdom. paulhunt28@yahoo.co.uk
FAU - Khosla, Rajat
AU  - Khosla R
LA  - eng
PT  - Journal Article
DEP - 20100928
PL  - United States
TA  - PLoS Med
JT  - PLoS medicine
JID - 101231360
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Drug Industry/economics/*ethics
MH  - Global Health
MH  - *Human Rights
MH  - Humans
MH  - International Cooperation
MH  - Pharmaceutical Preparations
MH  - Public Health
MH  - Public Policy
MH  - *United Nations
PMC - PMC2946950
EDAT- 2010/10/12 06:00
MHDA- 2011/01/19 06:00
CRDT- 2010/10/08 06:00
PHST- 2010/10/08 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2011/01/19 06:00 [medline]
AID - 10.1371/journal.pmed.1000330 [doi]
PST - epublish
SO  - PLoS Med. 2010 Sep 28;7(9):e1000330. doi: 10.1371/journal.pmed.1000330.


PMID- 20927356
OWN - NLM
STAT- MEDLINE
DCOM- 20110118
LR  - 20211020
IS  - 1549-1676 (Electronic)
IS  - 1549-1277 (Linking)
VI  - 7
IP  - 9
DP  - 2010 Sep 28
TI  - Are drug companies living up to their human rights responsibilities? Moving
      toward assessment.
PG  - e1000310
LID - 10.1371/journal.pmed.1000310 [doi]
LID - e1000310 [pii]
AB  - BACKGROUND TO THE DEBATE: The human rights responsibilities of drug companies
      have been considered for years by nongovernmental organizations, but were most
      sharply defined in a report by the UN Special Rapporteur on the right to health, 
      submitted to the United Nations General Assembly in August 2008. The "Human
      Rights Guidelines for Pharmaceutical Companies in relation to Access to
      Medicines" include responsibilities for transparency, management, monitoring and 
      accountability, pricing, and ethical marketing, and against lobbying for more
      protection in intellectual property laws, applying for patents for trivial
      modifications of existing medicines, inappropriate drug promotion, and excessive 
      pricing. Two years after the release of the Guidelines, the PLoS Medicine Debate 
      asks whether drug companies are living up to their human rights responsibilities.
      Sofia Gruskin and Zyde Raad from the Harvard School of Public Health say more
      assessment is needed of such responsibilities; Geralyn Ritter, Vice President of 
      Global Public Policy and Corporate Responsibility at Merck & Co. argues that
      multiple stakeholders could do more to help States deliver the right to health;
      and Paul Hunt and Rajat Khosla introduce Mr. Hunt's work as the UN Special
      Rapporteur on the right to the highest attainable standard of health, regarding
      the human rights responsibilities of pharmaceutical companies and access to
      medicines.
FAU - Gruskin, Sofia
AU  - Gruskin S
AD  - Program on International Health and Human Rights, Department of Global Health and
      Population, Harvard School of Public Health, Boston, Massachusetts, USA.
      sgruskin@hsph.harvard.edu
FAU - Raad, Zyde
AU  - Raad Z
LA  - eng
PT  - Journal Article
DEP - 20100928
PL  - United States
TA  - PLoS Med
JT  - PLoS medicine
JID - 101231360
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Drug Industry/*ethics
MH  - *Human Rights
MH  - Humans
MH  - Organizations
MH  - Pharmaceutical Preparations
MH  - Public Policy
MH  - United Nations
PMC - PMC2946953
EDAT- 2010/10/12 06:00
MHDA- 2011/01/19 06:00
CRDT- 2010/10/08 06:00
PHST- 2010/10/08 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2011/01/19 06:00 [medline]
AID - 10.1371/journal.pmed.1000310 [doi]
PST - epublish
SO  - PLoS Med. 2010 Sep 28;7(9):e1000310. doi: 10.1371/journal.pmed.1000310.


PMID- 20927355
OWN - NLM
STAT- MEDLINE
DCOM- 20110118
LR  - 20211020
IS  - 1549-1676 (Electronic)
IS  - 1549-1277 (Linking)
VI  - 7
IP  - 9
DP  - 2010 Sep 28
TI  - Are drug companies living up to their human rights responsibilities? The Merck
      perspective.
PG  - e1000343
LID - 10.1371/journal.pmed.1000343 [doi]
LID - e1000343 [pii]
AB  - BACKGROUND TO THE DEBATE: The human rights responsibilities of drug companies
      have been considered for years by nongovernmental organizations, but were most
      sharply defined in a report by the UN Special Rapporteur on the right to health, 
      submitted to the United Nations General Assembly in August 2008. The "Human
      Rights Guidelines for Pharmaceutical Companies in relation to Access to
      Medicines" include responsibilities for transparency, management, monitoring and 
      accountability, pricing, and ethical marketing, and against lobbying for more
      protection in intellectual property laws, applying for patents for trivial
      modifications of existing medicines, inappropriate drug promotion, and excessive 
      pricing. Two years after the release of the Guidelines, the PLoS Medicine Debate 
      asks whether drug companies are living up to their human rights responsibilities.
      Sofia Gruskin and Zyde Raad from the Harvard School of Public Health say more
      assessment is needed of such responsibilities; Geralyn Ritter, Vice President of 
      Global Public Policy and Corporate Responsibility at Merck & Co. argues that
      multiple stakeholders could do more to help States deliver the right to health;
      and Paul Hunt and Rajat Khosla introduce Mr. Hunt's work as the UN Special
      Rapporteur on the right to the highest attainable standard of health, regarding
      the human rights responsibilities of pharmaceutical companies and access to
      medicines.
FAU - Ritter, Geralyn S
AU  - Ritter GS
AD  - Merck & Co., Whitehouse Station, New Jersey, USA. geralyn.ritter@merck.com
LA  - eng
PT  - Journal Article
DEP - 20100928
PL  - United States
TA  - PLoS Med
JT  - PLoS medicine
JID - 101231360
SB  - IM
MH  - Drug Industry/*ethics
MH  - *Human Rights/legislation & jurisprudence
MH  - Humans
MH  - Marketing/ethics
MH  - Organizations/ethics
MH  - Public Policy/legislation & jurisprudence
MH  - Social Responsibility
MH  - United Nations
PMC - PMC2946952
EDAT- 2010/10/12 06:00
MHDA- 2011/01/19 06:00
CRDT- 2010/10/08 06:00
PHST- 2010/10/08 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2011/01/19 06:00 [medline]
AID - 10.1371/journal.pmed.1000343 [doi]
PST - epublish
SO  - PLoS Med. 2010 Sep 28;7(9):e1000343. doi: 10.1371/journal.pmed.1000343.


PMID- 20927158
OWN - NLM
STAT- MEDLINE
DCOM- 20101029
LR  - 20110406
IS  - 1175-8716 (Electronic)
IS  - 0028-8446 (Linking)
VI  - 123
IP  - 1321
DP  - 2010 Aug 27
TI  - Getting tangled in red tape: the challenges of doing clinical research in New
      Zealand.
PG  - 54-8
AB  - Regulations and the number of forms that require completion remain a major
      frustration for researchers attempting to establish a clinical research project. 
      It is essential that clinical research is of the highest standard and abides by
      ethical principles. However, the duplication of information required and lack of 
      co-ordination between national and local ethics and research committees is a
      hindrance to conducting clinical research. This publication highlights the
      pitfalls in our current system with a case study, and suggests changes to the
      ethical review process that may aid researchers in establishing clinical
      research.
FAU - Loveday, Sarah
AU  - Loveday S
AD  - Department of Paediatrics, Faculty of Medical and Health Sciences, University of 
      Auckland, Grafton, Auckland 1023, New Zealand.
FAU - Mitchell, Ed
AU  - Mitchell E
LA  - eng
PT  - Journal Article
DEP - 20100827
PL  - New Zealand
TA  - N Z Med J
JT  - The New Zealand medical journal
JID - 0401067
SB  - IM
MH  - Advisory Committees
MH  - Biomedical Research/*legislation & jurisprudence
MH  - Ethical Review
MH  - Ethics Committees, Research
MH  - Government Regulation
MH  - Humans
MH  - New Zealand
EDAT- 2010/10/12 06:00
MHDA- 2010/10/30 06:00
CRDT- 2010/10/08 06:00
PHST- 2010/10/08 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2010/10/30 06:00 [medline]
PST - epublish
SO  - N Z Med J. 2010 Aug 27;123(1321):54-8.


PMID- 20926830
OWN - NLM
STAT- MEDLINE
DCOM- 20110719
LR  - 20110314
IS  - 1092-874X (Electronic)
IS  - 1091-5818 (Linking)
VI  - 29
IP  - 6
DP  - 2010 Dec
TI  - Developmental toxicity testing of biopharmaceuticals in nonhuman primates:
      previous experience and future directions.
PG  - 552-68
LID - 10.1177/1091581810378896 [doi]
AB  - Developmental toxicity studies for pharmaceutical safety testing are designed to 
      evaluate potential adverse effects of drug treatment on pregnancy and on the
      developing embryo/fetus. Biopharmaceuticals present specific challenges for
      developmental toxicity testing because the pharmacology of these molecules, which
      are frequently human-specific proteins, is often restricted to humans and
      nonhuman primates (NHPs). For those species-restricted molecules, the only option
      for the evaluation of potential effects on development of the human
      biopharmaceutical is to use NHPs. This article reviews each of the stages of
      development in cynomolgus macaques (the most frequently used NHP) and the
      potential exposure of the embryo, fetus, and infant following administration of a
      biopharmaceutical during pregnancy and lactation. Because the purpose of the NHP 
      developmental studies is to identify potential human risks, a comparison between 
      macaque and human development and potential exposure has been made when possible.
      Understanding the potential exposure of the conceptus relative to critical
      periods in development is essential to designing a scientifically based study
      that adequately addresses human risks. Some options for NHP study designs,
      including the option of combining end points into a single study, and the pros
      and cons of each of the study options have been reviewed. Developmental studies
      for biopharmaceuticals in NHPs need to be optimally designed on a case-by-case
      basis taking into consideration the pharmacology of the molecule, the type of
      molecule (antibody or non-antibody), the potential exposure relative to the
      development of potential target organs, the clinical use, and the ethical
      considerations associated with the use of NHPs.
CI  - (c) The Author(s) 2010
FAU - Martin, Pauline L
AU  - Martin PL
AD  - Centocor Research and Development, Inc, 145 King of Prussia Road, Radnor, PA
      19087, USA. pmarti27@its.jnj.com
FAU - Weinbauer, Gerhard F
AU  - Weinbauer GF
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
DEP - 20101006
PL  - United States
TA  - Int J Toxicol
JT  - International journal of toxicology
JID - 9708436
RN  - 0 (Recombinant Proteins)
RN  - 0 (Teratogens)
SB  - IM
MH  - Animals
MH  - Drug Evaluation, Preclinical/*trends
MH  - Drug Hypersensitivity/immunology/prevention & control
MH  - Embryonic Development/drug effects
MH  - Female
MH  - Fetal Development/drug effects
MH  - Humans
MH  - Lactation
MH  - Macaca fascicularis
MH  - Male
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Recombinant Proteins/*toxicity
MH  - Species Specificity
MH  - Teratogens/*toxicity
MH  - Toxicity Tests/trends
EDAT- 2010/10/12 06:00
MHDA- 2011/07/20 06:00
CRDT- 2010/10/08 06:00
PHST- 2010/10/08 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2011/07/20 06:00 [medline]
AID - 1091581810378896 [pii]
AID - 10.1177/1091581810378896 [doi]
PST - ppublish
SO  - Int J Toxicol. 2010 Dec;29(6):552-68. doi: 10.1177/1091581810378896. Epub 2010
      Oct 6.


PMID- 20926408
OWN - NLM
STAT- MEDLINE
DCOM- 20120326
LR  - 20220330
IS  - 1465-735X (Electronic)
IS  - 0146-8693 (Linking)
VI  - 36
IP  - 10
DP  - 2011 Nov-Dec
TI  - The cold pressor task: is it an ethically acceptable pain research method in
      children?
PG  - 1071-81
LID - 10.1093/jpepsy/jsq092 [doi]
AB  - OBJECTIVES: The cold pressor task (CPT) is an experimental method of inducing
      pain. Ethical concerns have been raised regarding the nontherapeutic induction of
      pain in children. The objectives of this study were to describe the ethical
      challenges and acceptability of the CPT from the perspective of researchers,
      children and parents. METHODS: Study 1:16 researchers completed a survey
      regarding their experiences obtaining ethical approval and use of the CPT in
      pediatric research. Study 2: 175 children and 194 parents answered questions
      about their experiences participating in studies that used the CPT. RESULTS: Full
      ethics board review was generally required. Adverse events were rare and
      transient. The majority of researchers, children, and parents reported positive
      experiences with the CPT. CONCLUSIONS: The CPT is judged by researchers,
      children, and parents to be an acceptable research method. The CPT can be used
      ethically in pediatric research with appropriate study safeguards.
FAU - Birnie, Kathryn A
AU  - Birnie KA
AD  - Department of Psychology, Dalhousie University, Canada. kbirnie@dal.ca
FAU - Noel, Melanie
AU  - Noel M
FAU - Chambers, Christine T
AU  - Chambers CT
FAU - von Baeyer, Carl L
AU  - von Baeyer CL
FAU - Fernandez, Conrad V
AU  - Fernandez CV
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101005
PL  - United States
TA  - J Pediatr Psychol
JT  - Journal of pediatric psychology
JID - 7801773
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Data Collection
MH  - *Ethics, Research
MH  - Humans
MH  - Infant
MH  - Pain Measurement/*ethics
MH  - Parents
MH  - *Research Design
MH  - *Research Subjects
EDAT- 2010/10/12 06:00
MHDA- 2012/03/27 06:00
CRDT- 2010/10/08 06:00
PHST- 2010/10/08 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2012/03/27 06:00 [medline]
AID - jsq092 [pii]
AID - 10.1093/jpepsy/jsq092 [doi]
PST - ppublish
SO  - J Pediatr Psychol. 2011 Nov-Dec;36(10):1071-81. doi: 10.1093/jpepsy/jsq092. Epub 
      2010 Oct 5.


PMID- 20926254
OWN - NLM
STAT- MEDLINE
DCOM- 20111027
LR  - 20130502
IS  - 1873-4588 (Electronic)
IS  - 0892-1997 (Linking)
VI  - 25
IP  - 4
DP  - 2011 Jul
TI  - Effect of tonsillectomy on the adult voice.
PG  - e207-10
LID - 10.1016/j.jvoice.2010.05.006 [doi]
AB  - OBJECTIVES AND HYPOTHESIS: Anecdotal evidence suggests that tonsillectomy has no 
      deleterious consequences on a person's voice under normal vocal demand. However, 
      whether the enlarged dimensions of the oropharynx after tonsillectomy impair the 
      quality of a professional voice user remains unclear. Therefore, we designed a
      study to determine whether adult tonsillectomy altered the resonance
      characteristics of the vocal tract in any way and whether these changes were
      transient or permanent. STUDY DESIGN: This is a prospective observational study
      with full institutional ethical approval. METHODS: All adult patients presenting 
      for tonsillectomy for recurrent tonsillitis in our institution were recruited.
      Their voice was recorded preoperatively, postoperatively, and at 4 weeks
      postoperatively. The values of the first four formants were calculated in all
      recordings. The oropharyngeal dimensions were measured preoperatively and
      postoperatively. Tonsillar weights and volumes were also measured. RESULTS: The
      first formant was noted to rise postoperatively. The average value of F2 and F3
      did not alter postoperatively or at 4 weeks. However, it was noted that the
      fourth formant was not universally present preoperatively but was present in all 
      patients postoperatively and at 4 weeks. CONCLUSIONS: Altering the dimensions of 
      the oropharynx after tonsillectomy causes the first formant to rise but has no
      effect on the third and fourth formants. However, the fourth formant appears in
      patients who previously did not demonstrate it. The fourth formant was present in
      a greater proportion of male patients preoperatively than female patients, but it
      was universally present postoperatively and at 4 weeks in both sexes. This
      suggests that increasing the horizontal dimensions of the oropharynx has a
      nontransient effect on the higher order formants of the voice.
CI  - Copyright (c) 2011 The Voice Foundation. Published by Mosby, Inc. All rights
      reserved.
FAU - Heffernan, Colleen B
AU  - Heffernan CB
AD  - Royal Victoria Eye and Ear Hospital, Adelaide Road, Dublin, Ireland.
      heffernan_colleen@hotmail.com
FAU - Rafferty, Mark A
AU  - Rafferty MA
LA  - eng
PT  - Journal Article
DEP - 20101006
PL  - United States
TA  - J Voice
JT  - Journal of voice : official journal of the Voice Foundation
JID - 8712262
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - Humans
MH  - Male
MH  - Oropharynx/physiology
MH  - Prospective Studies
MH  - Tonsillectomy/*adverse effects
MH  - Voice/*physiology
MH  - Voice Disorders/etiology
MH  - Young Adult
EDAT- 2010/10/12 06:00
MHDA- 2011/10/28 06:00
CRDT- 2010/10/08 06:00
PHST- 2010/02/22 00:00 [received]
PHST- 2010/05/26 00:00 [accepted]
PHST- 2010/10/08 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2011/10/28 06:00 [medline]
AID - S0892-1997(10)00084-6 [pii]
AID - 10.1016/j.jvoice.2010.05.006 [doi]
PST - ppublish
SO  - J Voice. 2011 Jul;25(4):e207-10. doi: 10.1016/j.jvoice.2010.05.006. Epub 2010 Oct
      6.


PMID- 20925587
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20101118
IS  - 1651-2006 (Electronic)
IS  - 1401-7431 (Linking)
VI  - 44
IP  - 6
DP  - 2010 Dec
TI  - Non-inferiority randomized trials, an issue between science and ethics: the case 
      of the SYNTAX study.
PG  - 321-4
LID - 10.3109/14017431.2010.504859 [doi]
AB  - Non-inferiority trials are questionable when death and serious complications are 
      included among outcomes. The term itself "non-inferiority" is misleading, since
      such a study would not demonstrate that a new treatment is non-inferior to a
      control treatment, but simply that the inferiority would not reach a
      pre-specified level, deemed as acceptable by the designers of the trial. Group
      cross-over, assay-sensitivity and the need of a placebo arm are major issues for 
      the reliability of non-inferiority trials. The SYNTAX trial for severe coronary
      artery disease was designed on a non-inferiority margin of 6.6%. In this paper we
      show that the SYNTAX designers were ready to accept up to 30% higher rate of
      death and major adverse events to claim the non-inferiority of percutaneous
      coronary intervention versus coronary artery bypass grafting. Eventually the
      SYNTAX study failed because percutaneous patients sustained an even higher rate
      of adverse events. We propose major caution in performing non-inferiority
      randomized trials.
FAU - Mantovani, Vittorio
AU  - Mantovani V
AD  - Department of Cardiac Surgery, University of Insubria and Ospedale di Circolo di 
      Varese, Varese, Italy. vitmantovani@hotmail.com
FAU - Lepore, Vincenzo
AU  - Lepore V
FAU - Mira, Antonietta
AU  - Mira A
FAU - Berglin, Eva
AU  - Berglin E
LA  - eng
PT  - Journal Article
DEP - 20101007
PL  - England
TA  - Scand Cardiovasc J
JT  - Scandinavian cardiovascular journal : SCJ
JID - 9708377
SB  - IM
MH  - *Angioplasty, Balloon, Coronary
MH  - *Coronary Artery Bypass
MH  - Coronary Artery Disease/*surgery/therapy
MH  - Data Interpretation, Statistical
MH  - Endpoint Determination
MH  - *Ethics, Research
MH  - Europe
MH  - Humans
MH  - Randomized Controlled Trials as Topic/*ethics
MH  - Research Design
EDAT- 2010/10/12 06:00
MHDA- 2011/06/03 06:00
CRDT- 2010/10/08 06:00
PHST- 2010/10/08 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
AID - 10.3109/14017431.2010.504859 [doi]
PST - ppublish
SO  - Scand Cardiovasc J. 2010 Dec;44(6):321-4. doi: 10.3109/14017431.2010.504859. Epub
      2010 Oct 7.


PMID- 20925304
OWN - NLM
STAT- MEDLINE
DCOM- 20101123
LR  - 20101007
IS  - 1259-4792 (Print)
IS  - 1259-4792 (Linking)
IP  - 256
DP  - 2010 Sep-Oct
TI  - [Ethics of the care given to premature newborns].
PG  - 27-9
AB  - The treatment of premature newborns has evolved a lot in France over the last
      decade. It can be examined with regard to the four main principles of biomedical 
      ethics: beneficence, non-maleficence, autonomy and justice. Consequently the
      combination of medical-nursing vigilance and individualised developmental care
      enables the premature baby to benefit from truly "ethical" healthcare.
FAU - Gold, Francis
AU  - Gold F
AD  - Universite Pierre et Marie Curie-Paris 6. francis.gold@trs.aphp.fr
FAU - Lointier, Francoise
AU  - Lointier F
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Ethique des soins au nouveau-ne premature.
PL  - France
TA  - Soins Pediatr Pueric
JT  - Soins. Pediatrie, puericulture
JID - 9604503
MH  - Child Advocacy/*ethics
MH  - Child Development
MH  - France
MH  - Humans
MH  - Infant, Newborn
MH  - *Infant, Premature
MH  - Intensive Care, Neonatal/*ethics/trends
MH  - Neonatal Nursing/*ethics/trends
MH  - Patient Care Planning/ethics
MH  - *Principle-Based Ethics
EDAT- 2010/10/12 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/10/08 06:00
PHST- 2010/10/08 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - Soins Pediatr Pueric. 2010 Sep-Oct;(256):27-9.


PMID- 20925221
OWN - NLM
STAT- MEDLINE
DCOM- 20101028
LR  - 20161206
IS  - 1210-7832 (Print)
IS  - 1210-7832 (Linking)
VI  - 75
IP  - 4
DP  - 2010 Aug
TI  - [Ethics in neonatal intensive care].
PG  - 268-74
AB  - Work summarises current data ideas of problems of ethical thinking and decision
      making in neonatology. Primary objective ethical questions of administration
      resuscitative and intensive care are outlined, as well as administration of care 
      for babies, delivered on limit of viability, in the same way for children with
      high probability of serious damage in case of survival. Role of parents in
      decision making about to other administration care is discussed, some
      recommendation and instructions for communication with parents are handed up.
      Findings of extensive european study named EURONIC are shortly mentioned, study
      concerns problems of ethical dilemmas in neonatology in 8 European countries.
      Finally the categorization of newborns in ethical thinking is mentioned and
      present circumstances in Czech republic are remarked.
FAU - Macko, Jozef
AU  - Macko J
AD  - Macko J. Novorozenecke oddeleni, Krajska nemocnice T. Bati, a.s., Zlin.
LA  - cze
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Etika neonatalni intenzivni pece.
PL  - Czech Republic
TA  - Ceska Gynekol
JT  - Ceska gynekologie
JID - 9423768
SB  - IM
MH  - Cardiopulmonary Resuscitation
MH  - Czech Republic
MH  - Decision Making
MH  - Dissent and Disputes
MH  - Humans
MH  - Infant, Newborn
MH  - Intensive Care, Neonatal/*ethics
MH  - Withholding Treatment/ethics
EDAT- 2010/10/12 06:00
MHDA- 2010/10/29 06:00
CRDT- 2010/10/08 06:00
PHST- 2010/10/08 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2010/10/29 06:00 [medline]
PST - ppublish
SO  - Ceska Gynekol. 2010 Aug;75(4):268-74.


PMID- 20925211
OWN - NLM
STAT- MEDLINE
DCOM- 20101021
LR  - 20181201
IS  - 0970-258X (Print)
IS  - 0970-258X (Linking)
VI  - 23
IP  - 2
DP  - 2010 Mar-Apr
TI  - An interesting meeting on medical ethics.
PG  - 104-5
FAU - Manjrekar, Phalakshi
AU  - Manjrekar P
AD  - P. D. Hinduja National Hospital and Medical Research Centre, Veer Savarkar Marg, 
      Mahim, Mumbai. phalakshi.manjrekar@hindujahospital.com
FAU - Palaha, Harvinder
AU  - Palaha H
FAU - Pandya, Sunil K
AU  - Pandya SK
LA  - eng
PT  - Congress
PL  - India
TA  - Natl Med J India
JT  - The National medical journal of India
JID - 8809315
SB  - IM
MH  - *Ethics, Medical
MH  - Humans
EDAT- 2010/10/12 06:00
MHDA- 2010/10/22 06:00
CRDT- 2010/10/08 06:00
PHST- 2010/10/08 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2010/10/22 06:00 [medline]
PST - ppublish
SO  - Natl Med J India. 2010 Mar-Apr;23(2):104-5.


PMID- 20925189
OWN - NLM
STAT- MEDLINE
DCOM- 20101123
LR  - 20101007
IS  - 0241-6972 (Print)
IS  - 0241-6972 (Linking)
IP  - 270
DP  - 2010 Sep-Oct
TI  - [Ethics and psychiatry].
PG  - 34
FAU - Regent, Liliane
AU  - Regent L
AD  - ERFPS, CHU de Rouen.
LA  - fre
PT  - Bibliography
TT  - Ethique et psychiatrie.
PL  - France
TA  - Soins Psychiatr
JT  - Soins. Psychiatrie
JID - 8203334
MH  - Humans
MH  - Patient Advocacy/*ethics
MH  - Psychiatric Nursing/*ethics
MH  - Psychiatry/*ethics
EDAT- 2010/10/12 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/10/08 06:00
PHST- 2010/10/08 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - Soins Psychiatr. 2010 Sep-Oct;(270):34.


PMID- 20925188
OWN - NLM
STAT- MEDLINE
DCOM- 20101123
LR  - 20101007
IS  - 0241-6972 (Print)
IS  - 0241-6972 (Linking)
IP  - 270
DP  - 2010 Sep-Oct
TI  - [From policy to unique care in psychiatry, the place of ethics].
PG  - 30-3
AB  - Ethical reflection is an aid to psychiatrists in their role as caregiver and
      policy implementer. Ethics takes root in commitment, the act of resistance
      enables the caregiver not to be carried away by the dominant approach, but rather
      to be an individual subject respecting the singularity of others.
FAU - Touzet, Patrick
AU  - Touzet P
AD  - Centre hospitalier Les Murets, La Queue-en-Brie. rahontouzet@free.fr
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - De la politique au soin singulier en psychiatrie, la place de l'ethique.
PL  - France
TA  - Soins Psychiatr
JT  - Soins. Psychiatrie
JID - 8203334
MH  - France
MH  - *Health Policy
MH  - Humans
MH  - Patient Care Planning/*ethics
MH  - Philosophy, Medical
MH  - Philosophy, Nursing
MH  - Psychiatric Nursing/*ethics
MH  - Psychiatry/*ethics
MH  - Thinking
EDAT- 2010/10/12 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/10/08 06:00
PHST- 2010/10/08 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - Soins Psychiatr. 2010 Sep-Oct;(270):30-3.


PMID- 20925186
OWN - NLM
STAT- MEDLINE
DCOM- 20101123
LR  - 20191210
IS  - 0241-6972 (Print)
IS  - 0241-6972 (Linking)
IP  - 270
DP  - 2010 Sep-Oct
TI  - [The ethics of the nursing commitment in psychiatry].
PG  - 24-6
AB  - The referral nurse represents the care environment, he/she is the guarantor of
      the care plan and forms a commitment with regard to the patient. This
      positioning, arising from the empathy he/she has for the patient in a situation
      of vulnerability, may lead him/her to object to and question a medical decision.
FAU - Tregouet, Stephane
AU  - Tregouet S
AD  - Hopital An Tremen, Vannes. stephane.tregouet@cegetel.net
LA  - fre
PT  - Case Reports
PT  - Journal Article
TT  - Pour une ethique de l'engagement infirmier en psychiatrie.
PL  - France
TA  - Soins Psychiatr
JT  - Soins. Psychiatrie
JID - 8203334
MH  - Conflict, Psychological
MH  - Dissent and Disputes
MH  - Empathy
MH  - Female
MH  - Humans
MH  - Nurse's Role
MH  - Nurse-Patient Relations/ethics
MH  - Patient Admission
MH  - Patient Advocacy/*ethics
MH  - Patient Care Planning/*ethics/organization & administration
MH  - *Physician-Nurse Relations
MH  - Psychiatric Nursing/*ethics/organization & administration
MH  - Psychiatry/*ethics/organization & administration
EDAT- 2010/10/12 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/10/08 06:00
PHST- 2010/10/08 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - Soins Psychiatr. 2010 Sep-Oct;(270):24-6.


PMID- 20925184
OWN - NLM
STAT- MEDLINE
DCOM- 20101123
LR  - 20171116
IS  - 0241-6972 (Print)
IS  - 0241-6972 (Linking)
IP  - 270
DP  - 2010 Sep-Oct
TI  - [Mental health film festival and ethics].
PG  - 18-20
AB  - The mental health film festival is based on the respect of the patient as a
      subject and is a place where psychic suffering can be expressed. As a film is
      destined to be shown, there is a dilemma between the aesthetic and the
      therapeutic aspects and, it's in this link that the ethical dimension concerned
      by this kind of activity takes place.
FAU - Simonnet, Daniel
AU  - Simonnet D
AD  - Hopital Maison Blanche, Paris. danielsimonnet@hotmail.com
LA  - fre
PT  - Journal Article
TT  - Atelier video et ethique en sante mentale.
PL  - France
TA  - Soins Psychiatr
JT  - Soins. Psychiatrie
JID - 8203334
MH  - Esthetics
MH  - Health Fairs/*ethics
MH  - Humans
MH  - Mental Health
MH  - Motion Pictures/*ethics
MH  - Paris
MH  - Patient Advocacy/*ethics
MH  - Psychiatry/*ethics
MH  - Videotape Recording/*ethics
EDAT- 2010/10/12 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/10/08 06:00
PHST- 2010/10/08 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - Soins Psychiatr. 2010 Sep-Oct;(270):18-20.


PMID- 20925183
OWN - NLM
STAT- MEDLINE
DCOM- 20101123
LR  - 20101007
IS  - 0241-6972 (Print)
IS  - 0241-6972 (Linking)
IP  - 270
DP  - 2010 Sep-Oct
TI  - [What are the ethics of care in mental health disorders?].
PG  - 14-7
AB  - Psychiatry is undergoing a major crisis, on both an institutional as well as a
      clinical level. Numerous players involved in psychiatry feel in difficulty and
      are increasingly raising questions as to what direction and meaning to give to
      their practice. It is in such a context that ethics can help us to progress,
      reflect and build the future together. It is high time to create the specific
      basis of ethics in psychiatry.
FAU - Godart, Elsa
AU  - Godart E
AD  - Universitaire et de la licence d'ethique, universite de Paris-Est,
      Marne-la-Vallee. elsagodart@aol.com
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Quelle ethique du soin pour les pathologies mentales?
PL  - France
TA  - Soins Psychiatr
JT  - Soins. Psychiatrie
JID - 8203334
MH  - Forecasting
MH  - Humans
MH  - Mental Disorders/*therapy
MH  - Patient Advocacy/*ethics
MH  - Personal Autonomy
MH  - Philosophy, Medical
MH  - Principle-Based Ethics
MH  - Psychiatry/*ethics/trends
EDAT- 2010/10/12 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/10/08 06:00
PHST- 2010/10/08 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - Soins Psychiatr. 2010 Sep-Oct;(270):14-7.


PMID- 20925182
OWN - NLM
STAT- MEDLINE
DCOM- 20101123
LR  - 20140325
IS  - 0241-6972 (Print)
IS  - 0241-6972 (Linking)
IP  - 270
DP  - 2010 Sep-Oct
TI  - [Ethics and psychiatry].
PG  - 13
FAU - Touzet, Patrick
AU  - Touzet P
LA  - fre
PT  - Introductory Journal Article
TT  - Ethique et psychiatrie.
PL  - France
TA  - Soins Psychiatr
JT  - Soins. Psychiatrie
JID - 8203334
MH  - Clinical Competence
MH  - Freedom
MH  - Humans
MH  - Paternalism
MH  - Patient Advocacy/*ethics
MH  - Psychiatric Nursing/*ethics
MH  - Psychiatry/*ethics
EDAT- 2010/10/12 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/10/08 06:00
PHST- 2010/10/08 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - Soins Psychiatr. 2010 Sep-Oct;(270):13.


PMID- 20924864
OWN - NLM
STAT- MEDLINE
DCOM- 20101228
LR  - 20190116
IS  - 1549-7852 (Electronic)
IS  - 1040-8398 (Linking)
VI  - 50
IP  - 9
DP  - 2010 Oct
TI  - Active food packaging evolution: transformation from micro- to nanotechnology.
PG  - 799-821
LID - 10.1080/10408398.2010.503694 [doi]
AB  - Predicting which attributes consumers are willing to pay extra for has become
      straightforward in recent years. The demands for the prime necessity of food of
      natural quality, elevated safety, minimally processed, ready-to-eat, and longer
      shelf-life have turned out to be matters of paramount importance. The increased
      awareness of environmental conservation and the escalating rate of foodborne
      illnesses have driven the food industry to implement a more innovative solution, 
      i.e. bioactive packaging. Owing to nanotechnology application in eco-favorable
      coatings and encapsulation systems, the probabilities of enhancing food quality, 
      safety, stability, and efficiency have been augmented. In this review article,
      the collective results highlight the food nanotechnology potentials with special 
      focus on its application in active packaging, novel nano- and microencapsulation 
      techniques, regulatory issues, and socio-ethical scepticism between
      nano-technophiles and nano-technophobes. No one has yet indicated the comparison 
      of data concerning food nano- versus micro-technology; therefore noteworthy
      results of recent investigations are interpreted in the context of bioactive
      packaging. The next technological revolution in the domain of food science and
      nutrition would be the 3-BIOS concept enabling a controlled release of active
      agents through bioactive, biodegradable, and bionanocomposite combined strategy.
FAU - Imran, Muhammad
AU  - Imran M
AD  - Laboratoire d'Ingenierie des Biomolecules, ENSAIA-INPL, Nancy Universite, 2
      avenue de la Foret de Haye, 54505 Vandoeuvre-les-Nancy Cedex, France.
FAU - Revol-Junelles, Anne-Marie
AU  - Revol-Junelles AM
FAU - Martyn, Agnieszka
AU  - Martyn A
FAU - Tehrany, Elmira Arab
AU  - Tehrany EA
FAU - Jacquot, Muriel
AU  - Jacquot M
FAU - Linder, Michel
AU  - Linder M
FAU - Desobry, Stephane
AU  - Desobry S
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Crit Rev Food Sci Nutr
JT  - Critical reviews in food science and nutrition
JID - 8914818
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Liposomes)
RN  - 9012-76-4 (Chitosan)
RN  - EC 3.4.21.- (Lactoferrin)
SB  - IM
MH  - Anti-Infective Agents/metabolism
MH  - Biodegradation, Environmental
MH  - Chitosan/metabolism
MH  - *Consumer Product Safety
MH  - *Food Microbiology
MH  - Food Packaging/*methods
MH  - Food Preservation
MH  - Foodborne Diseases/prevention & control
MH  - Lactoferrin/metabolism
MH  - Liposomes
MH  - *Microtechnology
MH  - Nanotechnology/*trends
EDAT- 2010/10/07 06:00
MHDA- 2010/12/29 06:00
CRDT- 2010/10/07 06:00
PHST- 2010/10/07 06:00 [entrez]
PHST- 2010/10/07 06:00 [pubmed]
PHST- 2010/12/29 06:00 [medline]
AID - 927582345 [pii]
AID - 10.1080/10408398.2010.503694 [doi]
PST - ppublish
SO  - Crit Rev Food Sci Nutr. 2010 Oct;50(9):799-821. doi:
      10.1080/10408398.2010.503694.


PMID- 20924677
OWN - NLM
STAT- MEDLINE
DCOM- 20111205
LR  - 20211020
IS  - 1573-739X (Electronic)
IS  - 0928-1231 (Linking)
VI  - 32
IP  - 6
DP  - 2010 Dec
TI  - Generic and therapeutic substitutions: are they always ethical in their own
      terms?
PG  - 691-5
LID - 10.1007/s11096-010-9429-2 [doi]
AB  - Cost containment-driven drug substitution, whether generic or therapeutic, is
      defined as switching to another drug because it is cheaper. So far, such
      substitutions have drawn their public legitimacy from the general belief that
      they would not compromise the clinical interests of patients and certainly not
      violate their right to decline them if they did. This article does not enter the 
      debate on whether or not such substitutions must give exclusive priority to the
      patient's interests and choices in order to be ethical. Indeed, it acknowledges
      the plurality of views on this matter. It simply argues that when such
      substitutions involve a cheaper drug that is known to have different effects and 
      side effects, or even a drug whose effects and side effects are unknown, they are
      potentially deleterious to the patient, and that no competent and well-informed
      patient would ever consent to them. Such substitutions are thus unethical in
      their very own terms.
FAU - AlAmeri, Mubarak
AU  - AlAmeri M
AD  - Clinical Pharmacology, William Harvey Research Institute, Barts and The London,
      School of Medicine and Dentistry, Charterhouse Square, London, EC1M 6BQ, UK.
      m.al-ameri@qmul.ac.uk
FAU - Epstein, Miran
AU  - Epstein M
FAU - Johnston, Atholl
AU  - Johnston A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Germany
TA  - Pharm World Sci
JT  - Pharmacy world & science : PWS
JID - 9307352
RN  - 0 (Drugs, Generic)
SB  - IM
MH  - Clinical Trials as Topic/economics/ethics
MH  - Cost Control/economics/ethics
MH  - Drug Substitution/economics/*ethics
MH  - *Drugs, Generic/economics
MH  - Humans
EDAT- 2010/10/07 06:00
MHDA- 2011/12/13 00:00
CRDT- 2010/10/07 06:00
PHST- 2010/10/07 06:00 [entrez]
PHST- 2010/10/07 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/s11096-010-9429-2 [doi]
PST - ppublish
SO  - Pharm World Sci. 2010 Dec;32(6):691-5. doi: 10.1007/s11096-010-9429-2.


PMID- 20924446
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1998-376X (Electronic)
IS  - 0970-0358 (Linking)
VI  - 43
IP  - 1
DP  - 2010 Jan
TI  - The acute management of acid assault burns: A pragmatic approach.
PG  - 29-33
LID - 10.4103/0970-0358.63952 [doi]
AB  - This case series comprises 31 patients who were victims of acid assault burns.
      They were admitted for acute or reconstructive care to a regional burns unit. Ten
      patients were admitted late with suboptimal acute care and needed a total of 50
      reconstructive procedures. Of 13 patients admitted acutely, 7 had surgery
      performed after 48 hours of constant lavage while seven had urgent surgical
      debridement within 48 hours, followed by lavage. Although the number of
      reconstructive procedures performed in these two groups was similar, i.e., 20 and
      19, respectively, the magnitude of the deformity in the urgent surgery group was 
      significantly less than in the conventional surgery group. As in many cases of
      acute burns care, determining the evidence for best practice using a prospective,
      randomised, controlled comparison of conventional versus urgent surgery is
      difficult in view of the small number of cases involved. However, basing surgical
      practice on ethical principles, and in particular 'primum non nocere,' we propose
      that the urgent reduction of the chemical load on the skin by surgical
      debridement is appropriate in selected cases and should be considered in the
      acute management of these devastating injuries.
FAU - Burd, A
AU  - Burd A
AD  - Department of Surgery, Division of Plastic, Reconstructive and Aesthetic Surgery,
      The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong.
FAU - Ahmed, K
AU  - Ahmed K
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Indian J Plast Surg
JT  - Indian journal of plastic surgery : official publication of the Association of
      Plastic Surgeons of India
JID - 8405356
PMC - PMC2938618
OTO - NOTNLM
OT  - Acute management
OT  - chemical assault
OT  - surgical timing
EDAT- 2010/10/07 06:00
MHDA- 2010/10/07 06:01
CRDT- 2010/10/07 06:00
PHST- 2010/10/07 06:00 [entrez]
PHST- 2010/10/07 06:00 [pubmed]
PHST- 2010/10/07 06:01 [medline]
AID - 10.4103/0970-0358.63952 [doi]
PST - ppublish
SO  - Indian J Plast Surg. 2010 Jan;43(1):29-33. doi: 10.4103/0970-0358.63952.


PMID- 20924013
OWN - NLM
STAT- MEDLINE
DCOM- 20101008
LR  - 20161017
IS  - 1538-3598 (Electronic)
IS  - 0098-7484 (Linking)
VI  - 304
IP  - 13
DP  - 2010 Oct 6
TI  - Evaluating the risks of clinical research.
PG  - 1472-9
LID - 10.1001/jama.2010.1414 [doi]
AB  - The ethical appropriateness of clinical research depends on protecting
      participants from excessive risks. Yet no systematic framework has been developed
      to assess research risks, and as a result, investigators, funders, and review
      boards rely only on their intuitive judgments. Because intuitive judgments of
      risk are subject to well-documented cognitive biases, this approach raises
      concern that research participants are not being adequately protected. To address
      this situation, we delineate a method called the systematic evaluation of
      research risks (SERR), which evaluates the risks of research interventions by
      comparing these interventions with the risks of comparator activities that have
      been deemed acceptable. This method involves a 4-step process: (1) identify the
      potential harms posed by the proposed research intervention; (2) categorize the
      magnitude of the potential harms into 1 of 7 harm levels on a harm scale; (3)
      quantify or estimate the likelihood of each potential harm; and (4) compare the
      likelihood of each potential harm from the research intervention with the
      likelihood of harms of the same magnitude occurring as a result of an appropriate
      comparator activity. By explicitly delineating, quantifying, and comparing the
      risks of research interventions with the risks posed by appropriate comparator
      activities, SERR offers a way to minimize the influence of cognitive biases on
      the evaluation of research risks and thereby better protect research participants
      from excessive risks.
FAU - Rid, Annette
AU  - Rid A
AD  - Department of Bioethics, NIH Clinical Center, Bethesda, MD 20892, USA.
FAU - Emanuel, Ezekiel J
AU  - Emanuel EJ
FAU - Wendler, David
AU  - Wendler D
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - JAMA
JT  - JAMA
JID - 7501160
SB  - IM
EIN - JAMA. 2010 Dec 8;304(22):2484
MH  - Biomedical Research/*ethics
MH  - Biopsy/adverse effects
MH  - *Harm Reduction
MH  - Humans
MH  - Hypersensitivity/diagnosis
MH  - Likelihood Functions
MH  - Liver Diseases/diagnosis
MH  - *Risk Assessment
MH  - Skin Tests/adverse effects
EDAT- 2010/10/07 06:00
MHDA- 2010/10/12 06:00
CRDT- 2010/10/07 06:00
PHST- 2010/10/07 06:00 [entrez]
PHST- 2010/10/07 06:00 [pubmed]
PHST- 2010/10/12 06:00 [medline]
AID - 304/13/1472 [pii]
AID - 10.1001/jama.2010.1414 [doi]
PST - ppublish
SO  - JAMA. 2010 Oct 6;304(13):1472-9. doi: 10.1001/jama.2010.1414.


PMID- 20923817
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20161125
IS  - 1472-0213 (Electronic)
IS  - 1472-0205 (Linking)
VI  - 28
IP  - 9
DP  - 2011 Sep
TI  - 'To treat or not to treat'. Kerrie Wooltorton, lessons to learn.
PG  - 741-4
LID - 10.1136/emj.2010.100750 [doi]
AB  - One of the main reasons for contact of psychiatric patients with Accident and
      Emergency (A&E) departments is deliberate self-harm. The situation is often
      complicated by the patient's ambivalence about treatment. Kerrie Wooltorton was
      one such patient who presented to an A&E department after having self-harmed by
      taking a fatal dose of antifreeze. She had an Advance Decision forbidding any
      treatment for her overdose, and continued to refuse the treatment. Her wishes
      were honoured and she died 3&emsp14;days later. The case raises many ethical and 
      practice issues, and this review aims to clarify the medico legal position in
      such a situation. It draws on the Mental Capacity Act and case law, which clearly
      favour preservation of life, to argue that there are many lessons to learn from
      this case. There are enough safeguards for treating clinicians if they are not
      satisfied of the validity and applicability of the Advance Decision and decide to
      override it. Alternatively, any decision to follow the Advance Decision has to be
      objectively supported by evidence. The Mental Capacity Act itself allows for
      overriding the patient's wishes if certain criteria under the Mental Health Act
      are met. This route was not explored in the Wooltorton case and this is the main 
      lesson to learn.
FAU - Muzaffar, Sajid
AU  - Muzaffar S
AD  - Norvic Clinic, Thorpe St Andrews, Norwich NR7 0HT, UK. sajidmuzaffar@yahoo.co.in
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20101005
PL  - England
TA  - Emerg Med J
JT  - Emergency medicine journal : EMJ
JID - 100963089
SB  - IM
MH  - Adult
MH  - Advance Directives/ethics/*legislation & jurisprudence
MH  - Bioethical Issues
MH  - Ethics, Medical
MH  - Female
MH  - Humans
MH  - Mental Competency/*legislation & jurisprudence
MH  - Right to Die/ethics/*legislation & jurisprudence
MH  - Suicide, Attempted/legislation & jurisprudence/*prevention & control
MH  - Treatment Refusal/ethics/*legislation & jurisprudence
MH  - United Kingdom
EDAT- 2010/10/07 06:00
MHDA- 2011/11/09 06:00
CRDT- 2010/10/07 06:00
PHST- 2010/10/07 06:00 [entrez]
PHST- 2010/10/07 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - emj.2010.100750 [pii]
AID - 10.1136/emj.2010.100750 [doi]
PST - ppublish
SO  - Emerg Med J. 2011 Sep;28(9):741-4. doi: 10.1136/emj.2010.100750. Epub 2010 Oct 5.


PMID- 20923593
OWN - NLM
STAT- MEDLINE
DCOM- 20110216
LR  - 20101026
IS  - 1471-6348 (Electronic)
IS  - 0266-4623 (Linking)
VI  - 26
IP  - 4
DP  - 2010 Oct
TI  - Implanting inequality: empirical evidence of social and ethical risks of
      implantable radio-frequency identification (RFID) devices.
PG  - 370-6
LID - 10.1017/S0266462310001133 [doi]
AB  - OBJECTIVES: The aim of this study was to assess empirically the social and
      ethical risks associated with implantable radio-frequency identification (RFID)
      devices. METHODS: Qualitative research included observational studies in
      twenty-three U.S. hospitals that have implemented new patient identification
      systems and eighty semi-structured interviews about the social and ethical
      implications of new patient identification systems, including RFID implants.
      RESULTS: The study identified three primary social and ethical risks associated
      with RFID implants: (i) unfair prioritization of patients based on their
      participation in the system, (ii) diminished trust of patients by care providers,
      and (iii) endangerment of patients who misunderstand the capabilities of the
      systems. CONCLUSIONS: RFID implants may aggravate inequalities in access to care 
      without any clear health benefits. This research underscores the importance of
      critically evaluating new healthcare technologies from the perspective of both
      normative ethics and empirical ethics.
FAU - Monahan, Torin
AU  - Monahan T
AD  - Department of Human & Organizational Development, Vanderbilt University, Peabody 
      #90, 230 Appleton Place, Nashville, Tennessee 37203-5721, USA.
      torin.monahan@vanderbilt.edu)
FAU - Fisher, Jill A
AU  - Fisher JA
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20101006
PL  - England
TA  - Int J Technol Assess Health Care
JT  - International journal of technology assessment in health care
JID - 8508113
SB  - IM
MH  - Female
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Patient Identification Systems/ethics
MH  - Prostheses and Implants/*adverse effects
MH  - Radio Frequency Identification Device/*ethics
MH  - Risk Assessment
MH  - United States
EDAT- 2010/10/07 06:00
MHDA- 2011/02/17 06:00
CRDT- 2010/10/07 06:00
PHST- 2010/10/07 06:00 [entrez]
PHST- 2010/10/07 06:00 [pubmed]
PHST- 2011/02/17 06:00 [medline]
AID - S0266462310001133 [pii]
AID - 10.1017/S0266462310001133 [doi]
PST - ppublish
SO  - Int J Technol Assess Health Care. 2010 Oct;26(4):370-6. doi:
      10.1017/S0266462310001133. Epub 2010 Oct 6.


PMID- 20923585
OWN - NLM
STAT- MEDLINE
DCOM- 20110216
LR  - 20220331
IS  - 1471-6348 (Electronic)
IS  - 0266-4623 (Linking)
VI  - 26
IP  - 4
DP  - 2010 Oct
TI  - Information on ethical issues in health technology assessment: how and where to
      find them.
PG  - 441-9
LID - 10.1017/S0266462310000954 [doi]
AB  - BACKGROUND: Comprehensive health technology assessments (HTAs) include thorough
      reflections on ethical issues associated with health technologies, their use, and
      value-based decisions in the assessment process. As methods of information
      retrieval for effectiveness assessments are not applicable to information
      retrieval on ethical issues, a specific methodological approach is necessary.
      OBJECTIVES: In the absence of existing adapted methods, our objective was to
      develop a methodological approach for the systematic retrieval of information on 
      ethical issues related to health technologies. METHOD AND RESULTS: A literature
      search was conducted to verify the non-existence of published comprehensive
      methodological approaches for the information retrieval on ethical issues for
      HTAs, and resulted in no hits. We, therefore, developed a step-by-step workflow
      following the workflow of information retrieval for effectiveness assessments:
      Step 1: Translation of the search question using the PICO scheme and additional
      components. Step 2: Concept building by modeling and linking search components.
      Step 3: Identification of synonyms in all relevant languages. Step 4: Selection
      of relevant information sources. Step 5: Design of search strategies for
      bibliographic databases. Step 6: Execution of search strategies and information
      seeking, including hand-searching. Step 7: Saving of retrieval results and
      standardized reporting of the process and results. Step 8: Final quality check
      and calculation of precision and recall. CONCLUSIONS: Systematic searching for
      information on ethical issues related to health technologies can be performed
      following the common retrieval workflow for effectiveness assessments, but should
      be performed separately applying adapted procedures and search terms on ethical
      issues relevant to the research question.
FAU - Droste, Sigrid
AU  - Droste S
AD  - Institute for Quality and Efficiency in Health Care (IQWiG), Dillenburger Strasse
      27, Cologne, Germany. sigrid.droste@iqwig.de
FAU - Dintsios, Charalabos-Markos
AU  - Dintsios CM
FAU - Gerber, Andreas
AU  - Gerber A
LA  - eng
PT  - Journal Article
DEP - 20101006
PL  - England
TA  - Int J Technol Assess Health Care
JT  - International journal of technology assessment in health care
JID - 8508113
SB  - IM
MH  - *Databases, Factual
MH  - *Information Storage and Retrieval
MH  - Internet
MH  - Technology Assessment, Biomedical/*ethics
EDAT- 2010/10/07 06:00
MHDA- 2011/02/17 06:00
CRDT- 2010/10/07 06:00
PHST- 2010/10/07 06:00 [entrez]
PHST- 2010/10/07 06:00 [pubmed]
PHST- 2011/02/17 06:00 [medline]
AID - S0266462310000954 [pii]
AID - 10.1017/S0266462310000954 [doi]
PST - ppublish
SO  - Int J Technol Assess Health Care. 2010 Oct;26(4):441-9. doi:
      10.1017/S0266462310000954. Epub 2010 Oct 6.


PMID- 20923580
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1756-994X (Electronic)
IS  - 1756-994X (Linking)
VI  - 2
IP  - 10
DP  - 2010 Oct 5
TI  - Stem cell banking: between traceability and identifiability.
PG  - 73
LID - 10.1186/gm194 [doi]
AB  - Stem cell banks are increasingly seen as an essential resource of biological
      materials for both basic and translational research. Stem cell banks support
      transnational access to quality-controlled and ethically sourced stem cell lines 
      from different origins and of varying grades. According to the Organisation for
      Economic Co-operation and Development, advances in regenerative medicine are
      leading to the development of a bioeconomy, 'a world where biotechnology
      contributes to a significant share of economic output'. Consequently, stem cell
      banks are destined to constitute a pillar of the bioeconomy in many countries.
      While certain ethical and legal concerns are specific to the nature of stem
      cells, stem cell banking could do well to examine the approaches fostered by
      tissue banking generally. Indeed, the past decade has seen a move to simplify and
      harmonize biological tissue and data banking so as to foster international
      interoperability. In particular, the issues of consent and of traceability
      illustrate not only commonalities but the opportunity for stem cell banking to
      appreciate the lessons learned in biobanking generally. This paper analyzes
      convergence and divergence in issues surrounding policy harmonization,
      transnational sharing, informed consent, traceability and return of results in
      the context of stem cell banks.
FAU - Knoppers, Bartha M
AU  - Knoppers BM
AD  - Centre of Genomics and Policy, McGill University, 740 Dr Penfield Avenue, Suite
      5206, Montreal, QC, H3A 1A4, Canada. bartha.knoppers@mcgill.ca.
FAU - Isasi, Rosario
AU  - Isasi R
LA  - eng
PT  - Journal Article
DEP - 20101005
PL  - England
TA  - Genome Med
JT  - Genome medicine
JID - 101475844
PMC - PMC2988448
EDAT- 2010/10/07 06:00
MHDA- 2010/10/07 06:01
CRDT- 2010/10/07 06:00
PHST- 2010/10/07 06:00 [entrez]
PHST- 2010/10/07 06:00 [pubmed]
PHST- 2010/10/07 06:01 [medline]
AID - gm194 [pii]
AID - 10.1186/gm194 [doi]
PST - epublish
SO  - Genome Med. 2010 Oct 5;2(10):73. doi: 10.1186/gm194.


PMID- 20923508
OWN - NLM
STAT- MEDLINE
DCOM- 20101213
LR  - 20101006
IS  - 1744-1609 (Electronic)
IS  - 1744-1595 (Linking)
VI  - 8
IP  - 2
DP  - 2010 Jun
TI  - Ethical conduct of research in developing countries.
PG  - 43-4
LID - 10.1111/j.1744-1609.2010.00168.x [doi]
FAU - Clinton, Michael
AU  - Clinton M
LA  - eng
PT  - Editorial
PL  - Australia
TA  - Int J Evid Based Healthc
JT  - International journal of evidence-based healthcare
JID - 101247063
SB  - IM
MH  - *Developing Countries
MH  - *Ethics, Research
MH  - *Evidence-Based Practice/standards
MH  - Humans
MH  - International Cooperation
EDAT- 2010/10/07 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/10/07 06:00
PHST- 2010/10/07 06:00 [entrez]
PHST- 2010/10/07 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1111/j.1744-1609.2010.00168.x [doi]
PST - ppublish
SO  - Int J Evid Based Healthc. 2010 Jun;8(2):43-4. doi:
      10.1111/j.1744-1609.2010.00168.x.


PMID- 20923469
OWN - NLM
STAT- MEDLINE
DCOM- 20110202
LR  - 20101006
IS  - 1753-0407 (Electronic)
IS  - 1753-0407 (Linking)
VI  - 2
IP  - 1
DP  - 2010 Mar
TI  - Troubling ethical questions from gestational diabetes trial.
PG  - 1-4
LID - 10.1111/j.1753-0407.2009.00059.x [doi]
FAU - Bloomgarden, Zachary
AU  - Bloomgarden Z
LA  - eng
PT  - Comment
PT  - Editorial
DEP - 20091014
PL  - Australia
TA  - J Diabetes
JT  - Journal of diabetes
JID - 101504326
RN  - 0 (Blood Glucose)
SB  - IM
CON - J Diabetes. 2010 Mar;2(1):7-8. PMID: 20945540
CON - J Diabetes. 2010 Mar;2(1):5-6. PMID: 20945552
MH  - Blood Glucose/analysis
MH  - Blood Glucose Self-Monitoring/standards
MH  - Clinical Trials as Topic/*standards
MH  - Diabetes Mellitus, Type 2/blood/therapy
MH  - Diabetes, Gestational/blood/*therapy
MH  - *Ethics, Medical
MH  - Female
MH  - Humans
MH  - Pregnancy
MH  - Pregnancy in Diabetics/blood/therapy
MH  - Truth Disclosure/*ethics
EDAT- 2010/10/07 06:00
MHDA- 2011/02/03 06:00
CRDT- 2010/10/07 06:00
PHST- 2010/10/07 06:00 [entrez]
PHST- 2010/10/07 06:00 [pubmed]
PHST- 2011/02/03 06:00 [medline]
AID - 10.1111/j.1753-0407.2009.00059.x [doi]
PST - ppublish
SO  - J Diabetes. 2010 Mar;2(1):1-4. doi: 10.1111/j.1753-0407.2009.00059.x. Epub 2009
      Oct 14.


PMID- 20923249
OWN - NLM
STAT- MEDLINE
DCOM- 20110412
LR  - 20211020
IS  - 1179-1926 (Electronic)
IS  - 0312-5963 (Linking)
VI  - 49
IP  - 11
DP  - 2010 Nov
TI  - Fluoxetine disposition in patients with chronic hepatitis C treated with
      interferon-alpha.
PG  - 767-72
LID - 10.2165/11534720-000000000-00000 [doi]
AB  - BACKGROUND AND OBJECTIVES: Combination therapy with interferon-alpha and
      ribavirin is considered the treatment of choice for chronic hepatitis C. However,
      interferon-alpha may induce severe depression. It has been suggested that
      interferon-alpha is able to modify cytochrome P450 (CYP) 1A2 and 2D6 activity. We
      therefore decided to study the effects of the interferon-alpha-2b pegylated
      derivative on fluoxetine disposition in patients receiving combination
      chemotherapy for chronic hepatitis C. METHODS: After approval by the
      institutional ethics committee, 20 adult patients with chronic hepatitis C, but
      with no history of other liver diseases, were prospectively admitted to the
      study, which included phenotyping by means of a dextromethorphan test and
      evaluation of fluoxetine and norfluoxetine pharmacokinetic parameters (the area
      under the serum concentration-time curve, maximum serum concentration, time to
      reach the maximum serum concentration and terminal elimination half-life) before 
      and after 2 months of continuous peginterferon-alpha-2b therapy. RESULTS: The
      only statistically significant difference we observed was a significant reduction
      in the terminal elimination half-life of fluoxetine (from 47.30 to 33.23 hours; p
      = 0.014) after peginterferon-alpha-2b treatment. CONCLUSION: These data suggest
      that interferon-alpha may induce, rather than inhibit, the biotransformation of
      fluoxetine.
FAU - Furlanut, Mario
AU  - Furlanut M
AD  - Institute of Clinical Pharmacology and Toxicology, Department of Experimental and
      Clinical Pathology and Medicine, University of Udine, Udine, Italy.
      mario.furlanut@uniud.it
FAU - Soardo, Giorgio
AU  - Soardo G
FAU - Donnini, Debora
AU  - Donnini D
FAU - Sechi, Leonardo
AU  - Sechi L
FAU - Franceschi, Loretta
AU  - Franceschi L
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Clin Pharmacokinet
JT  - Clinical pharmacokinetics
JID - 7606849
RN  - 0 (Antidepressive Agents, Second-Generation)
RN  - 0 (Antiviral Agents)
RN  - 0 (Interferon alpha-2)
RN  - 0 (Interferon-alpha)
RN  - 0 (Recombinant Proteins)
RN  - 01K63SUP8D (Fluoxetine)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 49717AWG6K (Ribavirin)
RN  - G8RGG88B68 (peginterferon alfa-2b)
SB  - IM
MH  - Adult
MH  - Antidepressive Agents, Second-Generation/blood/*pharmacokinetics/therapeutic use
MH  - Antiviral Agents/*therapeutic use
MH  - Area Under Curve
MH  - Drug Interactions
MH  - Drug Therapy, Combination
MH  - Female
MH  - Fluoxetine/blood/*pharmacokinetics/therapeutic use
MH  - Half-Life
MH  - Hepacivirus/*drug effects/genetics
MH  - Hepatitis C, Chronic/*drug therapy/genetics/*metabolism
MH  - Humans
MH  - Interferon alpha-2
MH  - Interferon-alpha/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Phenotype
MH  - Polyethylene Glycols/*therapeutic use
MH  - Recombinant Proteins
MH  - Ribavirin/therapeutic use
MH  - Young Adult
EDAT- 2010/10/07 06:00
MHDA- 2011/04/13 06:00
CRDT- 2010/10/07 06:00
PHST- 2010/10/07 06:00 [entrez]
PHST- 2010/10/07 06:00 [pubmed]
PHST- 2011/04/13 06:00 [medline]
AID - 4 [pii]
AID - 10.2165/11534720-000000000-00000 [doi]
PST - ppublish
SO  - Clin Pharmacokinet. 2010 Nov;49(11):767-72. doi:
      10.2165/11534720-000000000-00000.


PMID- 20922484
OWN - NLM
STAT- MEDLINE
DCOM- 20110719
LR  - 20211203
IS  - 1386-9620 (Print)
IS  - 1386-9620 (Linking)
VI  - 14
IP  - 1
DP  - 2011 Mar
TI  - Probability model for estimating colorectal polyp progression rates.
PG  - 1-21
LID - 10.1007/s10729-010-9138-3 [doi]
AB  - According to the American Cancer Society, colorectal cancer (CRC) is the third
      most common cause of cancer related deaths in the United States. Experts estimate
      that about 85% of CRCs begin as precancerous polyps, early detection and
      treatment of which can significantly reduce the risk of CRC. Hence, it is
      imperative to develop population-wide intervention strategies for early detection
      of polyps. Development of such strategies requires precise values of
      population-specific rates of incidence of polyp and its progression to cancerous 
      stage. There has been a considerable amount of research in recent years on
      developing screening based CRC intervention strategies. However, these are not
      supported by population-specific mathematical estimates of progression rates.
      This paper addresses this need by developing a probability model that estimates
      polyp progression rates considering race and family history of CRC; note that, it
      is ethically infeasible to obtain polyp progression rates through clinical
      trials. We use the estimated rates to simulate the progression of polyps in the
      population of the State of Indiana, and also the population of a clinical trial
      conducted in the State of Minnesota, which was obtained from literature. The
      results from the simulations are used to validate the probability model.
FAU - Gopalappa, Chaitra
AU  - Gopalappa C
AD  - Department of Industrial and Management Systems Engineering, University of South 
      Florida, Tampa, FL 33620, USA. chaitrag@gmail.com
FAU - Aydogan-Cremaschi, Selen
AU  - Aydogan-Cremaschi S
FAU - Das, Tapas K
AU  - Das TK
FAU - Orcun, Seza
AU  - Orcun S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101005
PL  - Netherlands
TA  - Health Care Manag Sci
JT  - Health care management science
JID - 9815649
SB  - IM
MH  - Colonic Polyps/ethnology/genetics/*pathology
MH  - Colorectal Neoplasms/ethnology/genetics/*pathology
MH  - Computer Simulation
MH  - Disease Progression
MH  - Early Detection of Cancer/statistics & numerical data
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Incidence
MH  - Indiana/epidemiology
MH  - Minnesota/epidemiology
MH  - *Probability
MH  - Racial Groups
EDAT- 2010/10/06 06:00
MHDA- 2011/07/20 06:00
CRDT- 2010/10/06 06:00
PHST- 2009/11/14 00:00 [received]
PHST- 2010/09/13 00:00 [accepted]
PHST- 2010/10/06 06:00 [entrez]
PHST- 2010/10/06 06:00 [pubmed]
PHST- 2011/07/20 06:00 [medline]
AID - 10.1007/s10729-010-9138-3 [doi]
PST - ppublish
SO  - Health Care Manag Sci. 2011 Mar;14(1):1-21. doi: 10.1007/s10729-010-9138-3. Epub 
      2010 Oct 5.


PMID- 20922392
OWN - NLM
STAT- MEDLINE
DCOM- 20110621
LR  - 20211020
IS  - 1432-1084 (Electronic)
IS  - 0938-7994 (Linking)
VI  - 21
IP  - 4
DP  - 2011 Apr
TI  - Commercial software upgrades may significantly alter Perfusion CT parameter
      values in colorectal cancer.
PG  - 744-9
LID - 10.1007/s00330-010-1967-4 [doi]
AB  - OBJECTIVE: To determine how commercial software platform upgrades impact on
      derived parameters for colorectal cancer. MATERIALS AND METHODS: Following
      ethical approval, 30 patients with suspected colorectal cancer underwent
      Perfusion CT using integrated 64 detector PET/CT before surgery. Analysis was
      performed using software based on modified distributed parameter analysis
      (Perfusion software version 4; Perfusion 4.0), then repeated using the previous
      version (Perfusion software version 3; Perfusion 3.0). Tumour blood flow (BF),
      blood volume (BV), mean transit time (MTT) and permeability surface area product 
      (PS) were determined for identical regions-of-interest. Slice-by-slice and 'whole
      tumour' variance was assessed by Bland-Altman analysis. RESULTS: Mean BF, BV and 
      PS was 20.4%, 59.5%, and 106% higher, and MTT 14.3% shorter for Perfusion 4.0
      than Perfusion 3.0. The mean difference (95% limits of agreement) were +13.5
      (-44.9 to 72.0), +2.61 (-0.06 to 5.28), -1.23 (-6.83 to 4.36), and +14.2 (-4.43
      to 32.8) for BF, BV, MTT and PS respectively. Within subject coefficient of
      variation was 36.6%, 38.0%, 27.4% and 60.6% for BF, BV, MTT and PS respectively
      indicating moderate to poor agreement. CONCLUSION: Software version upgrades of
      the same software platform may result in significantly different parameter
      values, requiring adjustments for cross-version comparison.
FAU - Goh, Vicky
AU  - Goh V
AD  - Paul Strickland Scanner Centre, Mount Vernon Hospital, Rickmansworth Road,
      Northwood, Middlesex HA6 2RN, UK. vicky.goh@stricklandscanner.org.uk
FAU - Shastry, Manu
AU  - Shastry M
FAU - Engledow, Alec
AU  - Engledow A
FAU - Reston, Jonathan
AU  - Reston J
FAU - Wellsted, David M
AU  - Wellsted DM
FAU - Peck, Jacqui
AU  - Peck J
FAU - Endozo, Raymondo
AU  - Endozo R
FAU - Rodriguez-Justo, Manuel
AU  - Rodriguez-Justo M
FAU - Taylor, Stuart A
AU  - Taylor SA
FAU - Halligan, Steve
AU  - Halligan S
FAU - Groves, Ashley M
AU  - Groves AM
LA  - eng
PT  - Journal Article
DEP - 20101005
PL  - Germany
TA  - Eur Radiol
JT  - European radiology
JID - 9114774
RN  - 0 (Contrast Media)
SB  - IM
MH  - Adenocarcinoma/*diagnostic imaging/surgery
MH  - Aged
MH  - Aged, 80 and over
MH  - Colonic Neoplasms/*diagnostic imaging/surgery
MH  - Colorectal Neoplasms/*diagnostic imaging/surgery
MH  - Contrast Media/pharmacology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Perfusion
MH  - Radiographic Image Interpretation, Computer-Assisted/*instrumentation/methods
MH  - Rectal Neoplasms/*diagnostic imaging/surgery
MH  - Software
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2010/10/06 06:00
MHDA- 2011/06/22 06:00
CRDT- 2010/10/06 06:00
PHST- 2010/05/08 00:00 [received]
PHST- 2010/08/17 00:00 [accepted]
PHST- 2010/08/12 00:00 [revised]
PHST- 2010/10/06 06:00 [entrez]
PHST- 2010/10/06 06:00 [pubmed]
PHST- 2011/06/22 06:00 [medline]
AID - 10.1007/s00330-010-1967-4 [doi]
PST - ppublish
SO  - Eur Radiol. 2011 Apr;21(4):744-9. doi: 10.1007/s00330-010-1967-4. Epub 2010 Oct
      5.


PMID- 20922324
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20190608
IS  - 0104-1169 (Print)
IS  - 0104-1169 (Linking)
VI  - 18
IP  - 4
DP  - 2010 Jul-Aug
TI  - Humanization of care from the perspective of the family health strategy teams in 
      a city in the interior of Sao Paulo, Brazil.
PG  - 763-9
LID - S0104-11692010000400015 [pii]
AB  - This study analyzes the understanding of professionals composing teams of the
      Family Health Strategy concerning humanization of care. This qualitative survey
      was carried out in a city in the interior of Sao Paulo through interviews with 20
      professionals. The data analysis method used was Interpretation of Meanings based
      on the hermeneutic-dialectic perspective. The meaning of humanization according
      to the interviewed professionals includes an enlarged view, respect for ethical
      principles and facilitated access. The difficulties refer to the lack of prepared
      professionals, excessive demand and deficiencies in service organization. The
      professionals propose to educate and qualify professionals, make activities
      adequate given the professionals' roles and improve the organization of services.
      The professionals demonstrate understanding of the meaning of humanization and
      acknowledge the need to cope with difficulties.
FAU - Marin, Maria Jose Sanches
AU  - Marin MJ
AD  - Universidade Federal de Sao Paulo, SP, Brazil. marnadia@terra.com.br
FAU - Storniolo, Luana Vergian
AU  - Storniolo LV
FAU - Moravcik, Maria Yvette
AU  - Moravcik MY
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - Rev Lat Am Enfermagem
JT  - Revista latino-americana de enfermagem
JID - 9420934
MH  - Brazil
MH  - *Family Health
MH  - Health Services/*standards
MH  - *Health Services Accessibility
MH  - Humans
MH  - Interviews as Topic
MH  - *Patient Care Team/ethics
MH  - Workforce
EDAT- 2010/10/06 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/10/06 06:00
PHST- 2009/04/14 00:00 [received]
PHST- 2010/03/16 00:00 [accepted]
PHST- 2010/10/06 06:00 [entrez]
PHST- 2010/10/06 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - S0104-11692010000400015 [pii]
AID - 10.1590/s0104-11692010000400015 [doi]
PST - ppublish
SO  - Rev Lat Am Enfermagem. 2010 Jul-Aug;18(4):763-9. doi:
      10.1590/s0104-11692010000400015.


PMID- 20922111
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1998-3581 (Electronic)
IS  - 0970-0218 (Linking)
VI  - 35
IP  - 2
DP  - 2010 Apr
TI  - Assessment of Skeletal and Non-skeletal Fluorosis in Endemic Fluoridated Areas of
      Vidharbha Region, India: A Survey.
PG  - 298-301
LID - 10.4103/0970-0218.66868 [doi]
AB  - OBJECTIVES: To evaluate skeletal and non-skeletal fluorosis in patients living at
      endemic fluoridated areas and also the morphological changes in red blood cells
      (R.B.C.'s). MATERIALS AND METHODS: The cross-sectional study was conducted at
      Vidharbha region of Maharashtra, India. An ethical clearance was obtained from
      the concerned authorities. Fifty families were screened and 204 subjects who had 
      dental/skeletal fluorosis were included in the study. The aims and objectives
      were explained to the study subjects of the village and biochemical,
      hematological and radiological assessment was done. The main source of drinking
      water in this area was tube well. The concentrations of fluoride in two different
      areas of same village were 4 and 4.5 ppm. RESULTS: Prevalence of skeletal
      fluorosis and non-skeletal fluorosis in male patients was 56.87% (116) and in
      female patients (88) it was 43.13%. RBC count in male patients was 5.03 +/- 0.49 
      while in female patients it was 4.70 +/- 0.47. With significant difference
      between male and female patients, P value was 0.003. Hb% in male patients was
      12.44 +/- 1.76 and in female patients it was 11.31+/- 1.34, showing significant
      difference between male and female patients P value 0.038. Alkaline phosphate
      level in male patients was 289.68 +/- 149.09 and in female patients it was 276.68
      +/- 164.97. ESR count in male patients was found 11.41 +/- 8.75 and in female
      patients it was 13.29 +/-7.37. Radiological finding of fluorosis patients shows
      thickening of inner and outer tables of skull bone in 83.92% of patients and only
      7.84% of the patients were suffering from barrowing of long bone.
FAU - Rawlani, Sudhir
AU  - Rawlani S
AD  - Rajnandgeon, Chattisgarh, Sharad Pawar Dental College, DMIMS, Sawangi (M),
      Wardha, Maharashtra, India.
FAU - Rawlani, Shobha
AU  - Rawlani S
FAU - Rawlani, Shivlal
AU  - Rawlani S
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Community Med
JT  - Indian journal of community medicine : official publication of Indian Association
      of Preventive & Social Medicine
JID - 9315574
PMC - PMC2940190
OTO - NOTNLM
OT  - Biochemical
OT  - hematology
OT  - morphological
OT  - radiology
OT  - skeletal fluorosis
EDAT- 2010/10/06 06:00
MHDA- 2010/10/06 06:01
CRDT- 2010/10/06 06:00
PHST- 2009/07/09 00:00 [received]
PHST- 2010/03/27 00:00 [accepted]
PHST- 2010/10/06 06:00 [entrez]
PHST- 2010/10/06 06:00 [pubmed]
PHST- 2010/10/06 06:01 [medline]
AID - 10.4103/0970-0218.66868 [doi]
PST - ppublish
SO  - Indian J Community Med. 2010 Apr;35(2):298-301. doi: 10.4103/0970-0218.66868.


PMID- 20921861
OWN - NLM
STAT- MEDLINE
DCOM- 20101022
LR  - 20220330
IS  - 1539-736X (Electronic)
IS  - 0022-3018 (Linking)
VI  - 198
IP  - 10
DP  - 2010 Oct
TI  - Mobile interventions for severe mental illness: design and preliminary data from 
      three approaches.
PG  - 715-21
LID - 10.1097/NMD.0b013e3181f49ea3 [doi]
AB  - Mobile devices can be used to deliver psychosocial interventions, yet there is
      little prior application in severe mental illness. We provide the rationale,
      design, and preliminary data from 3 ongoing clinical trials of mobile
      interventions developed for bipolar disorder or schizophrenia. Project 1 used a
      personal digital assistant to prompt engagement in personalized self-management
      behaviors based on real-time data. Project 2 employed experience sampling through
      text messages to facilitate case management. Project 3 was built on group
      functional skills training for schizophrenia by incorporating between-session
      mobile phone contacts with therapists. Preliminary findings were of minimal
      participant attrition, and no broken devices; yet, several operational and
      technical barriers needed to be addressed. Adherence was similar to that reported
      in nonpsychiatric populations, with high participant satisfaction. Therefore,
      mobile devices seem feasible and acceptable in augmenting psychosocial
      interventions for severe mental illness, with future research in establishing
      efficacy, cost effectiveness, and ethical and safety protocols.
FAU - Depp, Colin A
AU  - Depp CA
AD  - Department of Psychiatry, University of California, San Diego, CA, USA.
      cdepp@ucsd.edu
FAU - Mausbach, Brent
AU  - Mausbach B
FAU - Granholm, Eric
AU  - Granholm E
FAU - Cardenas, Veronica
AU  - Cardenas V
FAU - Ben-Zeev, Dror
AU  - Ben-Zeev D
FAU - Patterson, Thomas L
AU  - Patterson TL
FAU - Lebowitz, Barry D
AU  - Lebowitz BD
FAU - Jeste, Dilip V
AU  - Jeste DV
LA  - eng
GR  - MH084967/MH/NIMH NIH HHS/United States
GR  - MH80002/MH/NIMH NIH HHS/United States
GR  - K23 MH077225/MH/NIMH NIH HHS/United States
GR  - P30 MH080002/MH/NIMH NIH HHS/United States
GR  - K23 MH077225-05/MH/NIMH NIH HHS/United States
GR  - MH077225/MH/NIMH NIH HHS/United States
GR  - MH091260/MH/NIMH NIH HHS/United States
GR  - R34 MH091260/MH/NIMH NIH HHS/United States
GR  - P30 MH080002-05/MH/NIMH NIH HHS/United States
GR  - R01 MH084967/MH/NIMH NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Nerv Ment Dis
JT  - The Journal of nervous and mental disease
JID - 0375402
SB  - IM
MH  - Adult
MH  - Bipolar Disorder/diagnosis/economics/psychology/*therapy
MH  - *Cell Phone/economics
MH  - *Computers, Handheld/economics
MH  - Controlled Clinical Trials as Topic
MH  - Cost-Benefit Analysis
MH  - Evidence-Based Medicine
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - *Psychotherapy/economics
MH  - Schizophrenia/diagnosis/economics/*therapy
MH  - *Schizophrenic Psychology
MH  - Self Care/economics/*psychology
MH  - *Therapy, Computer-Assisted/economics
PMC - PMC3215591
MID - NIHMS336129
EDAT- 2010/10/06 06:00
MHDA- 2010/10/23 06:00
CRDT- 2010/10/06 06:00
PHST- 2010/10/06 06:00 [entrez]
PHST- 2010/10/06 06:00 [pubmed]
PHST- 2010/10/23 06:00 [medline]
AID - 10.1097/NMD.0b013e3181f49ea3 [doi]
AID - 00005053-201010000-00003 [pii]
PST - ppublish
SO  - J Nerv Ment Dis. 2010 Oct;198(10):715-21. doi: 10.1097/NMD.0b013e3181f49ea3.


PMID- 20921337
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20210206
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Linking)
VI  - 117
IP  - 1
DP  - 2011 Jan 6
TI  - Remuneration of hematopoietic stem cell donors: principles and perspective of the
      World Marrow Donor Association.
PG  - 21-5
LID - 10.1182/blood-2010-07-298430 [doi]
AB  - Hematopoietic stem cell transplantation is a curative procedure for
      life-threatening hematologic diseases. Donation of hematopoietic stem cells
      (HSCs) from an unrelated donor, frequently residing in another country, may be
      the only option for 70% of those in need of unrelated hematopoietic stem cell
      transplantation. To maximize the opportunity to find the best available donor,
      individual donor registries collaborate internationally. To provide homogeneity
      of practice among registries, the World Marrow Donor Association (WMDA) sets
      standards against which registries are accredited and provides guidance and
      regulations about unrelated donor safety and care. A basic tenet of the donor
      registries is that unrelated HSC donation is an altruistic act; nonpayment of
      donors is entrenched in the WMDA standards and in international practice. In the 
      United States, the prohibition against remuneration of donors has recently been
      challenged. Here, we describe the reasons that the WMDA continues to believe that
      HSC donors should not be paid because of ethical concerns raised by remuneration,
      potential to damage the public will to act altruistically, the potential for
      coercion and exploitation of donors, increased risk to patients, harm to local
      transplantation programs and international stem cell exchange, and the
      possibility of benefiting some patients while disadvantaging others.
FAU - Boo, Michael
AU  - Boo M
AD  - National Marrow Donor Program, Minneapolis, MN, USA.
FAU - van Walraven, Suzanna M
AU  - van Walraven SM
FAU - Chapman, Jeremy
AU  - Chapman J
FAU - Lindberg, Brian
AU  - Lindberg B
FAU - Schmidt, Alexander H
AU  - Schmidt AH
FAU - Shaw, Bronwen E
AU  - Shaw BE
FAU - Switzer, Galen E
AU  - Switzer GE
FAU - Yang, Edward
AU  - Yang E
FAU - Egeland, Torstein
AU  - Egeland T
CN  - World Marrow Donor Association
LA  - eng
PT  - Journal Article
DEP - 20101004
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
SB  - IM
MH  - *Fees and Charges
MH  - Hematopoietic Stem Cell Transplantation/*standards
MH  - Humans
MH  - Registries/standards
MH  - Tissue Donors/*ethics
MH  - Tissue and Organ Procurement
MH  - United States
EDAT- 2010/10/06 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/10/06 06:00
PHST- 2010/10/06 06:00 [entrez]
PHST- 2010/10/06 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - S0006-4971(20)60136-7 [pii]
AID - 10.1182/blood-2010-07-298430 [doi]
PST - ppublish
SO  - Blood. 2011 Jan 6;117(1):21-5. doi: 10.1182/blood-2010-07-298430. Epub 2010 Oct
      4.


PMID- 20921259
OWN - NLM
STAT- MEDLINE
DCOM- 20101101
LR  - 20211020
IS  - 1488-2329 (Electronic)
IS  - 0820-3946 (Linking)
VI  - 182
IP  - 14
DP  - 2010 Oct 5
TI  - Clinical guidelines may need ethical component.
PG  - 1546-7
LID - 10.1503/cmaj.110-2113 [doi]
FAU - Gottgens-Jansen, W
AU  - Gottgens-Jansen W
FAU - van Leeuwen, E
AU  - van Leeuwen E
FAU - De Smet, P A G M
AU  - De Smet PA
FAU - Buitelaar, Jan K
AU  - Buitelaar JK
LA  - eng
PT  - Letter
PL  - Canada
TA  - CMAJ
JT  - CMAJ : Canadian Medical Association journal = journal de l'Association medicale
      canadienne
JID - 9711805
SB  - IM
EIN - CMAJ. 2010 Nov 23;182(17):1886. Gottens-Jansen, W [corrected to Gottgens-Jansen, 
      W]
MH  - *Ethics, Medical
MH  - Health Personnel
MH  - Humans
MH  - Practice Guidelines as Topic/*standards
MH  - Quality of Health Care
PMC - PMC2950191
EDAT- 2010/10/06 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/10/06 06:00
PHST- 2010/10/06 06:00 [entrez]
PHST- 2010/10/06 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - 182/14/1546-b [pii]
AID - 10.1503/cmaj.110-2113 [doi]
PST - ppublish
SO  - CMAJ. 2010 Oct 5;182(14):1546-7. doi: 10.1503/cmaj.110-2113.


PMID- 20920801
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20101005
IS  - 1873-6947 (Electronic)
IS  - 1744-3881 (Linking)
VI  - 16
IP  - 4
DP  - 2010 Nov
TI  - Development of ethical rules for boundaries of touch in complementary
      medicine--outcomes of a Delphi process.
PG  - 194-7
LID - 10.1016/j.ctcp.2010.05.009 [doi]
AB  - The practice of complementary medicine (CAM) often involves touch. The unique
      philosophy of many CAM therapies, and the setting in which treatments are
      provided create a therapeutic space which may be less clearly defined than in
      conventional settings - a space in which the boundaries between professional
      touch and personal/intimate touch may become easily obscured. Thus, complementary
      therapists need clear definitions and firm boundaries in order to maintain
      therapeutic efficacy and commitment. The aim of the process described in this
      article, was to develop ethical guidelines for boundaries of touch that will
      promote the safety and protection of the public which use CAM. Through a modified
      Delphi process, a diverse group of CAM practitioners, physicians, ethicists,
      legal consultants, health policy specialists, and representatives from the
      public, developed Ethical Rules for Boundaries of Touch in CAM. These guidelines 
      may be implemented in ethical codes of professional CAM organizations, and also
      serve as a foundation for curriculums in ethics in CAM schools.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Schiff, Elad
AU  - Schiff E
AD  - Department of Internal Medicine, Bnai-Zion Hospital, Haifa, Israel.
      eschiff@bezeqint.net
FAU - Ben-Arye, Eran
AU  - Ben-Arye E
FAU - Shilo, Margalit
AU  - Shilo M
FAU - Levy, Moti
AU  - Levy M
FAU - Schachter, Leora
AU  - Schachter L
FAU - Weitchner, Na'ama
AU  - Weitchner N
FAU - Golan, Ofra
AU  - Golan O
FAU - Stone, Julie
AU  - Stone J
LA  - eng
PT  - Journal Article
PL  - England
TA  - Complement Ther Clin Pract
JT  - Complementary therapies in clinical practice
JID - 101225531
MH  - *Codes of Ethics
MH  - Complementary Therapies/*ethics/standards
MH  - Delphi Technique
MH  - *Guidelines as Topic
MH  - Health Personnel/*ethics
MH  - Humans
MH  - *Touch
EDAT- 2010/10/06 06:00
MHDA- 2011/06/03 06:00
CRDT- 2010/10/06 06:00
PHST- 2010/04/27 00:00 [received]
PHST- 2010/05/11 00:00 [accepted]
PHST- 2010/10/06 06:00 [entrez]
PHST- 2010/10/06 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
AID - S1744-3881(10)00041-1 [pii]
AID - 10.1016/j.ctcp.2010.05.009 [doi]
PST - ppublish
SO  - Complement Ther Clin Pract. 2010 Nov;16(4):194-7. doi:
      10.1016/j.ctcp.2010.05.009.


PMID- 20920077
OWN - NLM
STAT- MEDLINE
DCOM- 20110128
LR  - 20151119
IS  - 1365-2702 (Electronic)
IS  - 0962-1067 (Linking)
VI  - 19
IP  - 17-18
DP  - 2010 Sep
TI  - Population-specific Mini Nutritional Assessment can improve
      mortality-risk-predicting ability in institutionalised older Taiwanese.
PG  - 2493-9
LID - 10.1111/j.1365-2702.2010.03299.x [doi]
AB  - AIM AND OBJECTIVES: The study determined whether a new version of the Mini
      Nutritional Assessment that adopted population-specific anthropometric cut-points
      would improve the mortality-predicting ability in institutionalised Taiwanese
      older people. BACKGROUND: Routine screening is the key for detecting emerging
      malnutrition, but the tool must be simple, reliable and easy-to-use to be well
      accepted. The Mini Nutritional Assessment can meet these requirements, but for
      non-Western populations, modifications based on anthropometric considerations are
      needed. DESIGN: The study purposively sampled 208 residents, aged >65 years, of a
      long-term care institution in Central Taiwan. Subjects were free of acute
      infection/disease and able to communicate. A university human-subject-study
      ethics committee approved the protocol. METHODS: The study included biochemical
      measurements and a structured questionnaire for eliciting personal data and
      answers to questions in the Mini Nutritional Assessment. Follow-up
      survival/mortality was tracked for two consecutive six-month periods and analysed
      according to nutritional statuses graded with the original or a modified Mini
      Nutritional Assessment. The modified version adopted population-specific
      anthropometric cut-points and was without body mass index. RESULTS: The
      modification improved the mortality-predictive ability. Mortality rates for the
      first six months were 8.7, 3.9 and 0% according to the original Mini Nutritional 
      Assessment and 10.6, 3.4 and 0% according to the modified version for subjects
      rated malnourished, at risk of malnutrition and normal, respectively. The
      mortality-predictive ability of both versions weakened after six months.
      CONCLUSION: Both versions can predict follow-up mortality, but the modified
      version has improved ability. For best results, the tool should be applied every 
      six months or less (shorter for more frail older people) to screen for new cases 
      of at-risk individuals. RELEVANCE TO CLINICAL PRACTICE: The Mini Nutritional
      Assessment that adopts population-specific anthropometric cut-points may have
      improved nutritional-risk and mortality-risk predictive abilities. The tool can
      help care-workers detect emerging nutritional problems and enable timely
      intervention. Routine use of the tool may help improve the quality of care.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Tsai, Alan C
AU  - Tsai AC
AD  - Graduate Institute of Long-term Care, Asia University, Wufeng, Taichung, Taiwan. 
      atsai@umich.edu
FAU - Ku, Pei-Yu
AU  - Ku PY
FAU - Tsai, Jeng-Dau
AU  - Tsai JD
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Clin Nurs
JT  - Journal of clinical nursing
JID - 9207302
MH  - Aged
MH  - Female
MH  - Forecasting
MH  - *Hospital Mortality
MH  - Humans
MH  - *Institutionalization
MH  - Male
MH  - *Nutrition Assessment
MH  - Risk Assessment/methods
MH  - Surveys and Questionnaires
MH  - Taiwan
EDAT- 2010/10/06 06:00
MHDA- 2011/02/01 06:00
CRDT- 2010/10/06 06:00
PHST- 2010/10/06 06:00 [entrez]
PHST- 2010/10/06 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
AID - 10.1111/j.1365-2702.2010.03299.x [doi]
PST - ppublish
SO  - J Clin Nurs. 2010 Sep;19(17-18):2493-9. doi: 10.1111/j.1365-2702.2010.03299.x.


PMID- 20920020
OWN - NLM
STAT- MEDLINE
DCOM- 20110128
LR  - 20220408
IS  - 1365-2702 (Electronic)
IS  - 0962-1067 (Linking)
VI  - 19
IP  - 13-14
DP  - 2010 Jul
TI  - Actively involving people with dementia in qualitative research.
PG  - 1935-43
LID - 10.1111/j.1365-2702.2009.03136.x [doi]
AB  - AIMS AND OBJECTIVES: This paper aims to: * Consider the major challenges to
      involving people with dementia in qualitative research. * Critique a process
      consent framework. * Demonstrate the need for nurses and researchers to explore
      these issues in research and practice with people with dementia. * Consider the
      impact of the Mental Capacity Act 2005 on research with people with dementia. To 
      achieve its aims, the authors will draw on current literature and use examples
      which explores the use of life story work with people with dementia by taking a
      qualitative approach. BACKGROUND: There is acceptance that researchers should
      consider ways of actively involving people with dementia in research as
      participants where appropriate to answering specific research questions. Process 
      consent methods have been advocated as an ethical way forward in recruiting and
      gaining consent for people with dementia, the Mental Capacity Act offers guidance
      to both practitioners and researchers. DESIGN AND METHOD: This paper does not
      seek to be a comprehensive review of the current literature but is a discussion
      paper appraising a process consent framework against current literature and
      drawing on the lead author's PhD study, exploring life story work with older
      people with dementia. RESULTS AND CONCLUSIONS: The Mental Capacity Act and
      process consent frameworks compliment one another, and their use should be
      considered when researching issues affecting older people with dementia.
      Researchers and practitioners should work more closely to ensure that the
      principles of process consent are achieved. Process consent models can equally be
      applied to everyday nursing practice. RELEVANCE TO CLINICAL PRACTICE: Process
      consent models can provide an ethical and practical framework to ensure that
      consent is continually assessed in people with dementia with all clinical
      interventions. The paper also draws on literature exploring practical ways of
      involving people with dementia in evaluating service delivery.
CI  - (c) 2010 The Authors. Journal compilation (c) 2010 Blackwell Publishing Ltd.
FAU - McKeown, Jane
AU  - McKeown J
AD  - Sheffield Health and Social Care NHS Foundation Trust, Service Development
      Directorate, Fulwood House, Sheffield, UK. Jane.Mckeown@shsc.nhs.uk
FAU - Clarke, Amanda
AU  - Clarke A
FAU - Ingleton, Christine
AU  - Ingleton C
FAU - Repper, Julie
AU  - Repper J
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Clin Nurs
JT  - Journal of clinical nursing
JID - 9207302
MH  - *Dementia
MH  - Humans
MH  - Informed Consent
MH  - *Patient Participation
MH  - *Qualitative Research
EDAT- 2010/10/06 06:00
MHDA- 2011/02/01 06:00
CRDT- 2010/10/06 06:00
PHST- 2010/10/06 06:00 [entrez]
PHST- 2010/10/06 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
AID - 10.1111/j.1365-2702.2009.03136.x [doi]
PST - ppublish
SO  - J Clin Nurs. 2010 Jul;19(13-14):1935-43. doi: 10.1111/j.1365-2702.2009.03136.x.


PMID- 20919587
OWN - NLM
STAT- MEDLINE
DCOM- 20110303
LR  - 20101005
IS  - 0253-1933 (Print)
IS  - 0253-1933 (Linking)
VI  - 29
IP  - 2
DP  - 2010 Aug
TI  - Why own an exotic pet?
PG  - 359-65, 351-8
AB  - Even though people have owned a wide variety of companion animals since times of 
      old, the modern craze for increasingly exotic and little-known species raises a
      number of questions, including some of an ethical nature. While trade in exotic
      animals is certainly profitable for these who practise it, it poses great risks
      of varying types: ecological risks, threats to biodiversity conservation and
      health risks. Several introduced animal populations have gone on to establish a
      line in their new host country. We are just starting to measure the adverse
      impact this has had, in some cases on a very large scale. The veterinary
      profession doubtless has a major role to play in endeavouring to reform this
      trade in living creatures that unfortunately results in many losses.
FAU - Moutou, F
AU  - Moutou F
AD  - Agence Francaise de Securite Sanitaire des Aliments (AFSSA), Laboratoire d'Etudes
      et de echerches en Pathologie Animale et Zoonoses (LERPAZ), 23 Avenue du
      General-de-Gaulle, 94706 Maisons-Alfort, France.
FAU - Pastoret, P P
AU  - Pastoret PP
LA  - eng
LA  - fre
PT  - Journal Article
PL  - France
TA  - Rev Sci Tech
JT  - Revue scientifique et technique (International Office of Epizootics)
JID - 8712301
SB  - IM
MH  - Animals
MH  - Carnivora
MH  - Chiroptera
MH  - Commerce/*ethics
MH  - Humans
MH  - Marsupialia
MH  - Ownership/*ethics
MH  - Pets/*classification
MH  - Primates
MH  - Rodentia
EDAT- 2010/10/06 06:00
MHDA- 2011/03/04 06:00
CRDT- 2010/10/06 06:00
PHST- 2010/10/06 06:00 [entrez]
PHST- 2010/10/06 06:00 [pubmed]
PHST- 2011/03/04 06:00 [medline]
PST - ppublish
SO  - Rev Sci Tech. 2010 Aug;29(2):359-65, 351-8.


PMID- 20919567
OWN - NLM
STAT- MEDLINE
DCOM- 20101230
LR  - 20101005
IS  - 0023-2149 (Print)
IS  - 0023-2149 (Linking)
VI  - 88
IP  - 4
DP  - 2010
TI  - [Current problems of deontology].
PG  - 30-4
AB  - The scope of knowledge in medical ethics continues to extend. Deontology as a
      science needs systematization of the accumulated data. This review may give
      impetus to classification of problems pertaining to this important area of
      medical activity.
FAU - Dimov, A S
AU  - Dimov AS
LA  - rus
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Russia (Federation)
TA  - Klin Med (Mosk)
JT  - Klinicheskaia meditsina
JID - 2985204R
SB  - IM
MH  - *Ethics, Medical
MH  - Humans
MH  - Physician-Patient Relations/*ethics
EDAT- 2010/10/06 06:00
MHDA- 2010/12/31 06:00
CRDT- 2010/10/06 06:00
PHST- 2010/10/06 06:00 [entrez]
PHST- 2010/10/06 06:00 [pubmed]
PHST- 2010/12/31 06:00 [medline]
PST - ppublish
SO  - Klin Med (Mosk). 2010;88(4):30-4.


PMID- 22296413
OWN - NLM
STAT- MEDLINE
DCOM- 20120904
LR  - 20151119
IS  - 1440-1754 (Electronic)
IS  - 1034-4810 (Linking)
VI  - 48
IP  - 5
DP  - 2012 May
TI  - Palivizumab: a debate about funding.
PG  - 373-7
LID - 10.1111/j.1440-1754.2010.01865.x [doi]
AB  - A clinician and the chair of the hospital drug committee debate the merits of the
      use of palivizumab as prophylaxis against respiratory syncytial virus infection
      for a preterm baby with oxygen-dependent, chronic lung disease and discuss the
      issue of public funding of palivizumab. An ethicist comments on ethical aspects
      of the debate about cost-effectiveness.
CI  - (c) 2010 The Authors. Journal of Paediatrics and Child Health (c) 2010
      Paediatrics and Child Health Division (Royal Australasian College of Physicians).
FAU - Fitzgerald, Dominic A
AU  - Fitzgerald DA
AD  - Department of Respiratory Medicine Infectious Diseases, Children's Hospital at
      Westmead, New South Wales, Australia.
FAU - Isaacs, David
AU  - Isaacs D
FAU - Tobin, Bernadette
AU  - Tobin B
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20101006
PL  - Australia
TA  - J Paediatr Child Health
JT  - Journal of paediatrics and child health
JID - 9005421
RN  - 0 (Antibodies, Monoclonal, Humanized)
RN  - 0 (Antiviral Agents)
RN  - DQ448MW7KS (Palivizumab)
SB  - IM
MH  - Antibodies, Monoclonal, Humanized/*economics/therapeutic use
MH  - Antiviral Agents/*economics/therapeutic use
MH  - Australia
MH  - Bronchopulmonary Dysplasia/complications
MH  - Cost-Benefit Analysis
MH  - *Drug Costs
MH  - Financing, Organized/*ethics
MH  - Health Care Rationing/economics/*ethics
MH  - Hospital Costs/*ethics
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Male
MH  - Palivizumab
MH  - Pharmacy and Therapeutics Committee/*ethics
MH  - Respiratory Syncytial Virus Infections/complications/prevention & control
EDAT- 2010/10/06 00:00
MHDA- 2012/09/05 06:00
CRDT- 2012/02/03 06:00
PHST- 2012/02/03 06:00 [entrez]
PHST- 2010/10/06 00:00 [pubmed]
PHST- 2012/09/05 06:00 [medline]
AID - 10.1111/j.1440-1754.2010.01865.x [doi]
PST - ppublish
SO  - J Paediatr Child Health. 2012 May;48(5):373-7. doi:
      10.1111/j.1440-1754.2010.01865.x. Epub 2010 Oct 6.


PMID- 20890939
OWN - NLM
STAT- MEDLINE
DCOM- 20110204
LR  - 20211020
IS  - 1542-0760 (Electronic)
IS  - 1542-0752 (Linking)
VI  - 88
IP  - 10
DP  - 2010 Oct
TI  - Assessment of benefits of a universal screen for maternal alcohol use during
      pregnancy.
PG  - 838-46
LID - 10.1002/bdra.20731 [doi]
AB  - INTRODUCTION: The objective of this report is to estimate the benefits of
      universal meconium screening for maternal drinking during pregnancy. Fetal
      alcohol spectrum disorder (FASD), including its most severe manifestation fetal
      alcohol syndrome (FAS), is preventable and remains a public health tragedy. The
      incidences of FAS and FASD have been conservatively estimated to be 0.97 and 10
      per 1000 births, respectively. Meconium testing has been demonstrated to be a
      promising at-birth method for detection of drinking during pregnancy. METHODS:
      The current costs of FAS and FASD, alcohol treatment programs, and meconium
      screening were estimated by literature review. Monetary values were converted
      roughly to equal dollars in 2006. RESULTS: Costs of adding meconium analysis to
      the current newborn screening program and of treatment for the identified mothers
      were estimated and compared to potential averted costs that may result from
      identification and intervention for mothers and affected infants. Three potential
      maternal treatment strategies are analyzed. Depending on the treatment type, the 
      savings may range from $6 to $97 for every $1 spent on screening and treatment.
      DISCUSSION: It needs to be emphasized, however, that such screening is premature 
      and that to be effective this screening can be implemented only if there is a
      societal willingness to institute prevention and intervention programs to improve
      both women's and children's health. Future research should be directed at
      improving detection and developing in-depth prevention and remedial intervention 
      programs. A thorough consideration of the ethical issues involved in such a
      screening program is also needed.
CI  - (c) 2010 Wiley-Liss, Inc.
FAU - Gifford, Anne E
AU  - Gifford AE
AD  - International Society for Disease Surveillance, Boston, Massachusetts, USA.
FAU - Farkas, Kathleen J
AU  - Farkas KJ
FAU - Jackson, Leila W
AU  - Jackson LW
FAU - Molteno, Christopher D
AU  - Molteno CD
FAU - Jacobson, Joseph L
AU  - Jacobson JL
FAU - Jacobson, Sandra W
AU  - Jacobson SW
FAU - Bearer, Cynthia F
AU  - Bearer CF
LA  - eng
GR  - R01 AA09524/AA/NIAAA NIH HHS/United States
GR  - P01 ES011261/ES/NIEHS NIH HHS/United States
GR  - R01 AA009524/AA/NIAAA NIH HHS/United States
GR  - R03 AA12618/AA/NIAAA NIH HHS/United States
GR  - R01 AA16398/AA/NIAAA NIH HHS/United States
GR  - U01 AA014790/AA/NIAAA NIH HHS/United States
GR  - R01 AA016398/AA/NIAAA NIH HHS/United States
GR  - P01 ES11261/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Birth Defects Res A Clin Mol Teratol
JT  - Birth defects research. Part A, Clinical and molecular teratology
JID - 101155107
RN  - 0 (Fatty Acids)
SB  - IM
MH  - Alcohol Drinking/economics/*epidemiology
MH  - Cohort Studies
MH  - *Cost-Benefit Analysis
MH  - Fatty Acids/analysis
MH  - Female
MH  - Fetal Alcohol Spectrum Disorders/*diagnosis/economics
MH  - Humans
MH  - Infant, Newborn
MH  - *Meconium
MH  - Models, Economic
MH  - Neonatal Screening/*economics/methods
MH  - Pregnancy
PMC - PMC3733546
MID - NIHMS489316
EDAT- 2010/10/05 06:00
MHDA- 2011/02/05 06:00
CRDT- 2010/10/05 06:00
PHST- 2010/10/05 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2011/02/05 06:00 [medline]
AID - 10.1002/bdra.20731 [doi]
PST - ppublish
SO  - Birth Defects Res A Clin Mol Teratol. 2010 Oct;88(10):838-46. doi:
      10.1002/bdra.20731.


PMID- 20890691
OWN - NLM
STAT- MEDLINE
DCOM- 20110307
LR  - 20171116
IS  - 1496-8975 (Electronic)
IS  - 0832-610X (Linking)
VI  - 57
IP  - 12
DP  - 2010 Dec
TI  - The impact of postoperative intensive care on outcomes in elective neurosurgical 
      patients in good physical condition: a single centre propensity case-matched
      study.
PG  - 1089-94
LID - 10.1007/s12630-010-9393-2 [doi]
AB  - PURPOSE: In the last three years, all elective neurosurgical cases were performed
      by a single surgeon at Nara Medical University. For the last year and a half, all
      patients were transferred to a newly created neurosurgical intensive care unit.
      The purpose of this study was to evaluate the impact of admission to an intensive
      care unit after elective neurosurgery. METHODS: This study was conducted as a
      retrospective clinical chart review. Institutional ethics approval was waived,
      and we reviewed the charts of 296 neurosurgical patients who were American
      Society of Anesthesiologists' physical status I-II. To avoid channelling bias,
      propensity score analysis was used to generate a set of matched cases (patients
      transferred to the intensive care unit [ICU]) and controls (patients transferred 
      to the neurosurgical ward). This process resulted in 104 matched pairs of
      elective surgical patients who did or did not have an ICU admission after
      surgery. Glasgow outcome scale (GOS) at discharge or at three months after the
      operation was compared as the primary outcome measure. As secondary outcome
      measures, we also compared rates of severe early complications and patient
      satisfaction regarding perioperative patient care. RESULTS: With an unmatched
      population, poor GOS tended to occur more often in the non-ICU group than in the 
      ICU group (6.5% vs 2.3%, respectively). Mortality rates and severe early
      complication rates also tended to be higher in the non-ICU group than in the ICU 
      group (2.4% and 5.3%, respectively, non-ICU group vs 0.8% and 2.3%, respectively,
      ICU group). However, after propensity score matching, there was no difference
      regarding the GOS between groups. Both groups showed very high good outcome
      percentages (98.1% ICU vs 97.1% non-ICU). With regard to mortality rates and
      severe early complications, both groups showed low mortality (0.96% vs 0.96%) and
      complication rates (2.89% ICU vs 3.85% non-ICU). Patient care in the ICU failed
      to increase patient satisfaction regarding the overall hospital care. CONCLUSION:
      The results of this analysis suggest that admission to an ICU after elective
      neurosurgery has little impact on outcomes.
FAU - Terada, Yuki
AU  - Terada Y
AD  - Department of Anesthesiology, Nara Medical University, Kashihara, Japan.
FAU - Inoue, Satoki
AU  - Inoue S
FAU - Tanaka, Yu
AU  - Tanaka Y
FAU - Kawaguchi, Masahiko
AU  - Kawaguchi M
FAU - Hirai, Katsuji
AU  - Hirai K
FAU - Furuya, Hitoshi
AU  - Furuya H
LA  - eng
PT  - Journal Article
DEP - 20101002
PL  - United States
TA  - Can J Anaesth
JT  - Canadian journal of anaesthesia = Journal canadien d'anesthesie
JID - 8701709
SB  - IM
MH  - Adult
MH  - Aged
MH  - Bias
MH  - Case-Control Studies
MH  - Critical Care/*methods
MH  - Elective Surgical Procedures/methods
MH  - Female
MH  - Glasgow Outcome Scale
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neurosurgical Procedures/adverse effects/*methods
MH  - Patient Satisfaction
MH  - Postoperative Care/*methods
MH  - Postoperative Complications/*epidemiology
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Time Factors
EDAT- 2010/10/05 06:00
MHDA- 2011/03/08 06:00
CRDT- 2010/10/05 06:00
PHST- 2010/05/31 00:00 [received]
PHST- 2010/09/16 00:00 [accepted]
PHST- 2010/10/05 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2011/03/08 06:00 [medline]
AID - 10.1007/s12630-010-9393-2 [doi]
PST - ppublish
SO  - Can J Anaesth. 2010 Dec;57(12):1089-94. doi: 10.1007/s12630-010-9393-2. Epub 2010
      Oct 2.


PMID- 20890562
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20110816
IS  - 2590-7379 (Electronic)
IS  - 0120-4157 (Linking)
VI  - 30
IP  - 2
DP  - 2010 Apr-Jun
TI  - [Integrated approach to neglected tropical diseases in Latin America and the
      Caribbean: an ethical imperative to reach justice and social equity].
PG  - 159-63
LID - S0120-41572010000200002 [pii]
FAU - Ault, Steven Kenyon
AU  - Ault SK
FAU - Nicholls, Ruben Santiago
AU  - Nicholls RS
LA  - spa
PT  - Editorial
TT  - El abordaje integral de las enfermedades tropicales desatendidas en America
      Latina y el Caribe: un imperativo etico para alcanzar la justicia y la equidad
      social.
PL  - Colombia
TA  - Biomedica
JT  - Biomedica : revista del Instituto Nacional de Salud
JID - 8205605
SB  - IM
MH  - Caribbean Region
MH  - Ethics
MH  - Humans
MH  - Latin America
MH  - *Neglected Diseases/epidemiology/prevention & control
MH  - Social Justice
MH  - Tropical Medicine
EDAT- 2010/10/05 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/10/05 06:00
PHST- 2010/10/05 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - S0120-41572010000200002 [pii]
PST - ppublish
SO  - Biomedica. 2010 Apr-Jun;30(2):159-63.


PMID- 20889876
OWN - NLM
STAT- MEDLINE
DCOM- 20101029
LR  - 20211020
IS  - 1476-1645 (Electronic)
IS  - 0002-9637 (Linking)
VI  - 83
IP  - 4
DP  - 2010 Oct
TI  - Centers for Disease Control light traps for monitoring Anopheles arabiensis human
      biting rates in an area with low vector density and high insecticide-treated bed 
      net use.
PG  - 838-42
LID - 10.4269/ajtmh.2010.10-0088 [doi]
AB  - Human landing catches (HLCs) are currently the preferred method to determine
      vector human biting rates (HBRs), which are key determinants of entomologic
      inoculation rates and important measures for assessing the impact of vector
      control efforts. Although HLCs are the most direct means of establishing HBRs,
      they are labor-intensive, and their use is facing increasing ethical concerns.
      The relationship between Centers for Disease Control (CDC) light traps and HLC
      collections was evaluated in Macha, Zambia during the 2007-2008 and 2008-2009
      rainy seasons. A CDC light trap captured on average 1.91 (95% confidence interval
      = 1.16-2.28) times as many An. arabiensis per night as an indoor HLC.
      Additionally, nets treated with deltamethrin did not affect the numbers of An.
      arabiensis collected. Our results suggest that in regions where use of vector
      control interventions is high and vector densities are low, CDC light traps can
      be used to monitor An. arabiensis HBRs.
FAU - Fornadel, Christen M
AU  - Fornadel CM
AD  - The W. Harry Feinstone Department of Molecular Microbiology and Immunology, The
      Johns Hopkins Malaria Research Institute, Johns Hopkins Bloomberg School of
      Public Health, Baltimore, Maryland 21205, USA. cfornade@jhsph.edu
FAU - Norris, Laura C
AU  - Norris LC
FAU - Norris, Douglas E
AU  - Norris DE
LA  - eng
GR  - T32 AI007417/AI/NIAID NIH HHS/United States
GR  - T32AI007417/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Trop Med Hyg
JT  - The American journal of tropical medicine and hygiene
JID - 0370507
RN  - 0 (Insecticides)
RN  - 0 (Nitriles)
RN  - 0 (Pyrethrins)
RN  - 2JTS8R821G (decamethrin)
SB  - IM
MH  - Animals
MH  - Anopheles/drug effects/*physiology
MH  - Centers for Disease Control and Prevention, U.S.
MH  - Humans
MH  - Insect Bites and Stings/*epidemiology
MH  - Insect Vectors/drug effects/physiology
MH  - *Insecticide-Treated Bednets
MH  - Insecticides/pharmacology
MH  - Mosquito Control/*instrumentation/methods
MH  - Nitriles/*pharmacology
MH  - Population Density
MH  - Pyrethrins/*pharmacology
MH  - Seasons
MH  - United States
MH  - Zambia/epidemiology
PMC - PMC2946753
EDAT- 2010/10/05 06:00
MHDA- 2010/10/30 06:00
CRDT- 2010/10/05 06:00
PHST- 2010/10/05 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2010/10/30 06:00 [medline]
AID - 83/4/838 [pii]
AID - 10.4269/ajtmh.2010.10-0088 [doi]
PST - ppublish
SO  - Am J Trop Med Hyg. 2010 Oct;83(4):838-42. doi: 10.4269/ajtmh.2010.10-0088.


PMID- 20889737
OWN - NLM
STAT- MEDLINE
DCOM- 20110204
LR  - 20161020
IS  - 1526-3347 (Electronic)
IS  - 0191-9601 (Linking)
VI  - 31
IP  - 10
DP  - 2010 Oct
TI  - Conceptual and ethical issues in the declaration of death.
PG  - 427-30
LID - 10.1542/pir.31-10-427 [doi]
FAU - Antommaria, Armand H Matheny
AU  - Antommaria AH
AD  - Division of Pediatric Inpatient Medicine, University of Utah School of Medicine, 
      Salt Lake City, Utah, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Pediatr Rev
JT  - Pediatrics in review
JID - 8103046
SB  - IM
MH  - *Bioethical Issues
MH  - Brain Death/*diagnosis
MH  - Coronary Circulation
MH  - Humans
MH  - Respiration
MH  - Tissue and Organ Procurement
EDAT- 2010/10/05 06:00
MHDA- 2011/02/05 06:00
CRDT- 2010/10/05 06:00
PHST- 2010/10/05 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2011/02/05 06:00 [medline]
AID - 31/10/427 [pii]
AID - 10.1542/pir.31-10-427 [doi]
PST - ppublish
SO  - Pediatr Rev. 2010 Oct;31(10):427-30. doi: 10.1542/pir.31-10-427.


PMID- 20889630
OWN - NLM
STAT- MEDLINE
DCOM- 20110127
LR  - 20170123
IS  - 1557-9700 (Electronic)
IS  - 1075-2730 (Linking)
VI  - 61
IP  - 10
DP  - 2010 Oct
TI  - Public-academic partnerships: the University of Hawai'i Rural Health
      Collaboration: partnerships to provide adult telepsychiatry services.
PG  - 961-3
LID - 10.1176/ps.2010.61.10.961 [doi]
AB  - To address the twofold problem of mental health disparities and limited access to
      health resources in rural areas, the University of Hawai'i Rural Health
      Collaboration aims to increase access to behavioral health services to rural
      areas across the state, primarily via telepsychiatry. The authors highlight
      lessons learned in regard to forging a university-community partnership,
      specifically community engagement for patient referral, the shift toward
      integrated services and away from a specialty clinic model, the importance of
      community diversity and contextual relevance, and ethical research and practice
      with indigenous communities.
FAU - Helm, Susana
AU  - Helm S
AD  - Department of Psychiatry, John A. Burns School of Medicine, University of Hawai'i
      at Mnoa, 1441 Kapi'olani Blvd., Honolulu, HI 96814, USA. helms@dop.hawaii.edu
FAU - Koyanagi, Chad
AU  - Koyanagi C
FAU - Else, 'Iwalani
AU  - Else '
FAU - Horton, Michelle
AU  - Horton M
FAU - Fukuda, Michael
AU  - Fukuda M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Psychiatr Serv
JT  - Psychiatric services (Washington, D.C.)
JID - 9502838
SB  - IM
MH  - *Cooperative Behavior
MH  - Hawaii
MH  - Humans
MH  - Program Development
MH  - Psychiatric Nursing/*methods
MH  - *Public Sector
MH  - Rural Population
MH  - *Telemedicine
MH  - *Universities
EDAT- 2010/10/05 06:00
MHDA- 2011/01/29 06:00
CRDT- 2010/10/05 06:00
PHST- 2010/10/05 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2011/01/29 06:00 [medline]
AID - 61/10/961 [pii]
AID - 10.1176/ps.2010.61.10.961 [doi]
PST - ppublish
SO  - Psychiatr Serv. 2010 Oct;61(10):961-3. doi: 10.1176/ps.2010.61.10.961.


PMID- 20889572
OWN - NLM
STAT- MEDLINE
DCOM- 20120409
LR  - 20111226
IS  - 1477-0334 (Electronic)
IS  - 0962-2802 (Linking)
VI  - 20
IP  - 6
DP  - 2011 Dec
TI  - A comparison of methods for sample size estimation for non-inferiority studies
      with binary outcomes.
PG  - 595-612
LID - 10.1177/0962280210378945 [doi]
AB  - Non-inferiority trials are motivated in the context of clinical research where a 
      proven active treatment exists and placebo-controlled trials are no longer
      acceptable for ethical reasons. Instead, active-controlled trials are conducted
      where a treatment is compared to an established treatment with the objective of
      demonstrating that it is non-inferior to this treatment. We review and compare
      the methodologies for calculating sample sizes and suggest appropriate methods to
      use. We demonstrate how the simplest method of using the anticipated response is 
      predominantly consistent with simulations. In the context of trials with binary
      outcomes with expected high proportions of positive responses, we show how the
      sample size is quite sensitive to assumptions about the control response. We
      recommend when designing such a study that sensitivity analyses be performed with
      respect to the underlying assumptions and that the Bayesian methods described in 
      this article be adopted to assess sample size.
FAU - Julious, Steven A
AU  - Julious SA
AD  - Medical Statistics Group, Health Services Research, University of Sheffield,
      Regent Court, 30 Regent Street, Sheffield, S1 4DA, UK.
      S.A.Julious@Sheffield.ac.uk
FAU - Owen, Roger J
AU  - Owen RJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
DEP - 20101001
PL  - England
TA  - Stat Methods Med Res
JT  - Statistical methods in medical research
JID - 9212457
SB  - IM
MH  - *Clinical Trials as Topic
MH  - Confidence Intervals
MH  - Research Design
MH  - *Sample Size
EDAT- 2010/10/05 06:00
MHDA- 2012/04/10 06:00
CRDT- 2010/10/05 06:00
PHST- 2010/10/05 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2012/04/10 06:00 [medline]
AID - 0962280210378945 [pii]
AID - 10.1177/0962280210378945 [doi]
PST - ppublish
SO  - Stat Methods Med Res. 2011 Dec;20(6):595-612. doi: 10.1177/0962280210378945. Epub
      2010 Oct 1.


PMID- 20889060
OWN - NLM
STAT- MEDLINE
DCOM- 20101019
LR  - 20180717
IS  - 1097-6752 (Electronic)
IS  - 0889-5406 (Linking)
VI  - 138
IP  - 4
DP  - 2010 Oct
TI  - Litigation, legislation, and ethics. Getting cold feet.
PG  - 525
LID - S0889-5406(10)00656-6 [pii]
LID - 10.1016/j.ajodo.2010.07.008 [doi]
FAU - Jerrold, Laurance
AU  - Jerrold L
AD  - Dean and program director, School of Orthodontics, Jacksonville University,
      Jacksonville, Fla.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Orthod Dentofacial Orthop
JT  - American journal of orthodontics and dentofacial orthopedics : official
      publication of the American Association of Orthodontists, its constituent
      societies, and the American Board of Orthodontics
JID - 8610224
SB  - IM
MH  - Contracts/*legislation & jurisprudence
MH  - Expert Testimony/*legislation & jurisprudence
MH  - Female
MH  - Humans
MH  - Malpractice/legislation & jurisprudence
MH  - Orthodontics/legislation & jurisprudence
MH  - Pennsylvania
EDAT- 2010/10/05 06:00
MHDA- 2010/10/20 06:00
CRDT- 2010/10/05 06:00
PHST- 2010/06/01 00:00 [received]
PHST- 2010/06/01 00:00 [revised]
PHST- 2010/07/01 00:00 [accepted]
PHST- 2010/10/05 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2010/10/20 06:00 [medline]
AID - S0889-5406(10)00656-6 [pii]
AID - 10.1016/j.ajodo.2010.07.008 [doi]
PST - ppublish
SO  - Am J Orthod Dentofacial Orthop. 2010 Oct;138(4):525. doi:
      10.1016/j.ajodo.2010.07.008.


PMID- 20888939
OWN - NLM
STAT- MEDLINE
DCOM- 20110210
LR  - 20101004
IS  - 1878-0369 (Electronic)
IS  - 0001-2092 (Linking)
VI  - 92
IP  - 4
DP  - 2010 Oct
TI  - Good work and ethics applied to the OR: lessons from musician Yo-Yo Ma.
PG  - 378-80
LID - 10.1016/j.aorn.2010.05.028 [doi]
FAU - Tetteh, Hassan A
AU  - Tetteh HA
LA  - eng
PT  - Editorial
PL  - United States
TA  - AORN J
JT  - AORN journal
JID - 0372403
SB  - IM
MH  - *Ethics
MH  - Operating Rooms/*organization & administration
MH  - United States
EDAT- 2010/10/05 06:00
MHDA- 2011/02/11 06:00
CRDT- 2010/10/05 06:00
PHST- 2010/05/04 00:00 [received]
PHST- 2010/05/17 00:00 [accepted]
PHST- 2010/10/05 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2011/02/11 06:00 [medline]
AID - S0001-2092(10)00774-X [pii]
AID - 10.1016/j.aorn.2010.05.028 [doi]
PST - ppublish
SO  - AORN J. 2010 Oct;92(4):378-80. doi: 10.1016/j.aorn.2010.05.028.


PMID- 20888722
OWN - NLM
STAT- MEDLINE
DCOM- 20110922
LR  - 20191210
IS  - 0736-4679 (Print)
IS  - 0736-4679 (Linking)
VI  - 40
IP  - 5
DP  - 2011 May
TI  - Ethics curriculum for emergency medicine graduate medical education.
PG  - 550-6
LID - 10.1016/j.jemermed.2010.05.076 [doi]
AB  - BACKGROUND: Ethics education is an essential component of graduate medical
      education in emergency medicine. A sound understanding of principles of bioethics
      and a rational approach to ethical decision-making are imperative. OBJECTIVE:
      This article addresses ethics curriculum content, educational approaches,
      educational resources, and resident feedback and evaluation. DISCUSSION: Ethics
      curriculum content should include elements suggested by the Liaison Committee on 
      Medical Education, Accreditation Council for Graduate Medical Education, and the 
      Model of the Clinical Practice of Emergency Medicine. Essential ethics content
      includes ethical principles, the physician-patient relationship, patient
      autonomy, clinical issues, end-of-life decisions, justice, education in emergency
      medicine, research ethics, and professionalism. CONCLUSION: The appropriate
      curriculum in ethics education in emergency medicine should include some of the
      content and educational approaches outlined in this article, although the optimal
      methods for meeting these educational goals may vary by institution.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Marco, Catherine A
AU  - Marco CA
AD  - Department of Emergency Medicine, University of Toledo College of Medicine,
      Toledo, Ohio 43614, USA.
FAU - Lu, Dave W
AU  - Lu DW
FAU - Stettner, Edward
AU  - Stettner E
FAU - Sokolove, Peter E
AU  - Sokolove PE
FAU - Ufberg, Jacob W
AU  - Ufberg JW
FAU - Noeller, Thomas P
AU  - Noeller TP
LA  - eng
PT  - Journal Article
DEP - 20101002
PL  - United States
TA  - J Emerg Med
JT  - The Journal of emergency medicine
JID - 8412174
SB  - IM
MH  - Bibliographies as Topic
MH  - Bioethics/*education
MH  - *Curriculum
MH  - *Education, Medical, Graduate
MH  - Emergency Medicine/*education
MH  - Humans
MH  - Models, Educational
EDAT- 2010/10/05 06:00
MHDA- 2011/09/23 06:00
CRDT- 2010/10/05 06:00
PHST- 2010/01/08 00:00 [received]
PHST- 2010/02/28 00:00 [revised]
PHST- 2010/05/18 00:00 [accepted]
PHST- 2010/10/05 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2011/09/23 06:00 [medline]
AID - S0736-4679(10)00527-5 [pii]
AID - 10.1016/j.jemermed.2010.05.076 [doi]
PST - ppublish
SO  - J Emerg Med. 2011 May;40(5):550-6. doi: 10.1016/j.jemermed.2010.05.076. Epub 2010
      Oct 2.


PMID- 20888610
OWN - NLM
STAT- MEDLINE
DCOM- 20110201
LR  - 20101019
IS  - 1476-5616 (Electronic)
IS  - 0033-3506 (Linking)
VI  - 124
IP  - 11
DP  - 2010 Nov
TI  - Ethics and values in prison practice.
PG  - 643-5
LID - 10.1016/j.puhe.2010.08.009 [doi]
AB  - A small series of pilot seminars on ethics and values in prison practice have
      been held over the past two years. This article outlines the background, the
      content and the relevance to prison staff. It concludes that a full trial of the 
      approach for both staff and prisoners would seem to be necessary and that the
      seminars should be tried with public health practitioners.
CI  - Copyright (c) 2010. Published by Elsevier Ltd.
FAU - Fraser, A
AU  - Fraser A
AD  - Scottish Prison Service, Edinburgh, UK.
FAU - Gatherer, A
AU  - Gatherer A
FAU - Bloom, S
AU  - Bloom S
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Public Health
JT  - Public health
JID - 0376507
SB  - IM
MH  - Humans
MH  - Inservice Training
MH  - Prisons/*ethics
MH  - *Social Values
EDAT- 2010/10/05 06:00
MHDA- 2011/02/02 06:00
CRDT- 2010/10/05 06:00
PHST- 2010/10/05 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2011/02/02 06:00 [medline]
AID - S0033-3506(10)00271-4 [pii]
AID - 10.1016/j.puhe.2010.08.009 [doi]
PST - ppublish
SO  - Public Health. 2010 Nov;124(11):643-5. doi: 10.1016/j.puhe.2010.08.009.


PMID- 20888605
OWN - NLM
STAT- MEDLINE
DCOM- 20110201
LR  - 20101019
IS  - 1476-5616 (Electronic)
IS  - 0033-3506 (Linking)
VI  - 124
IP  - 11
DP  - 2010 Nov
TI  - An evaluation of two ethical seminars.
PG  - 646-7
LID - 10.1016/j.puhe.2010.08.013 [doi]
AB  - The aims of two ethical seminars for prison staff are outlined and an evaluation 
      of the impact on those attending is given. The possible future use of such
      seminars for prison staff and possibly for public health practitioners is
      mentioned.
CI  - Copyright (c) 2010 The Royal Society for Public Health. Published by Elsevier
      Ltd. All rights reserved.
FAU - Durcan, G
AU  - Durcan G
AD  - Centre for Mental Health, London, United Kingdom.
      graham.durcan@centreformentalhealth.org.uk
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Public Health
JT  - Public health
JID - 0376507
SB  - IM
MH  - *Ethics
MH  - Humans
MH  - *Inservice Training
MH  - Prisons/ethics
MH  - *Program Evaluation
EDAT- 2010/10/05 06:00
MHDA- 2011/02/02 06:00
CRDT- 2010/10/05 06:00
PHST- 2010/10/05 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2011/02/02 06:00 [medline]
AID - S0033-3506(10)00275-1 [pii]
AID - 10.1016/j.puhe.2010.08.013 [doi]
PST - ppublish
SO  - Public Health. 2010 Nov;124(11):646-7. doi: 10.1016/j.puhe.2010.08.013.


PMID- 20888499
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20151119
IS  - 1531-6564 (Electronic)
IS  - 0363-5023 (Linking)
VI  - 35
IP  - 10
DP  - 2010 Oct
TI  - Relationships among pain disability, pain intensity, illness intrusiveness, and
      upper extremity disability in patients with traumatic peripheral nerve injury.
PG  - 1633-9
LID - 10.1016/j.jhsa.2010.07.018 [doi]
AB  - PURPOSE: In patients with a peripheral nerve injury, a simple conceptualization
      assumes that pain disability is determined by pain intensity. This study
      evaluated the relationships among pain intensity, illness intrusiveness, and pain
      disability. METHODS: After we obtained ethics board approval, we enrolled
      English-speaking adult patients who had experienced an upper extremity peripheral
      nerve injury 0.5 to 15 years previously. Patients completed the Disabilities of
      the Arm, Shoulder, and Hand (DASH), Illness Intrusiveness Scale, Pain Disability 
      Index, and McGill Pain questionnaires. We used multivariate linear regression to 
      evaluate the variables that predicted pain disability. RESULTS: There were 124
      patients (41 women, 83 men; mean +/- SD, 41 +/- 16 y of age). The median time
      since injury was 14 months (range, 6-145 months), and there were 43 brachial
      plexus nerve injuries. Mean +/- SD scores were: pain disability, 29 +/- 18;
      illness intrusiveness, 40 +/- 18; DASH, 45 +/- 22; and pain intensity, 4.6 +/-
      3.0. The pain disability, DASH, and illness intrusiveness scores were
      significantly higher in patients with brachial plexus injuries than in those with
      distal nerve injuries (p<.05). There was strong correlation between pain
      disability and DASH (r = 0.764, p<.001) and illness intrusiveness (r = 0.738,
      p<.001) and a weaker correlation with pain intensity (r = 0.549, p<.001). The
      final regression model predicting pain disability scores explained 70% of the
      variance with these predictors: DASH (beta = 0.452, p<.001), illness
      intrusiveness (beta = 0.372, p<.001), and pain intensity (beta = 0.143, p=.018). 
      CONCLUSIONS: Pain disability was substantial after nerve injury, and pain
      intensity explained the least variance among the model variables. Pain intensity 
      should be considered only one component of pain, and the impact of pain in the
      context of disability should be considered in patients with chronic nerve injury.
      TYPE OF STUDY/LEVEL OF EVIDENCE: Prognostic IV.
CI  - Copyright (c) 2010 American Society for Surgery of the Hand. Published by
      Elsevier Inc. All rights reserved.
FAU - Novak, Christine B
AU  - Novak CB
AD  - Institute of Medical Science, Division of Plastic & Reconstructive Surgery,
      Department of Health Policy, Management and Evaluation, University of Toronto,
      200 Elizabeth Street, Toronto, Ontario, Canada. christine.novak@utoronto.ca
FAU - Anastakis, Dimitri J
AU  - Anastakis DJ
FAU - Beaton, Dorcas E
AU  - Beaton DE
FAU - Mackinnon, Susan E
AU  - Mackinnon SE
FAU - Katz, Joel
AU  - Katz J
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Hand Surg Am
JT  - The Journal of hand surgery
JID - 7609631
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Disability Evaluation
MH  - Female
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Pain/*physiopathology
MH  - Pain Measurement
MH  - *Peripheral Nerve Injuries
MH  - Statistics, Nonparametric
MH  - Surveys and Questionnaires
MH  - Upper Extremity/*injuries/*physiopathology
EDAT- 2010/10/05 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/10/05 06:00
PHST- 2010/01/22 00:00 [received]
PHST- 2010/05/20 00:00 [revised]
PHST- 2010/07/13 00:00 [accepted]
PHST- 2010/10/05 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - S0363-5023(10)00838-5 [pii]
AID - 10.1016/j.jhsa.2010.07.018 [doi]
PST - ppublish
SO  - J Hand Surg Am. 2010 Oct;35(10):1633-9. doi: 10.1016/j.jhsa.2010.07.018.


PMID- 20888357
OWN - NLM
STAT- MEDLINE
DCOM- 20101207
LR  - 20101112
IS  - 1096-0333 (Electronic)
IS  - 0041-008X (Linking)
VI  - 249
IP  - 3
DP  - 2010 Dec 15
TI  - Reactivation of organophosphate-inhibited human, Cynomolgus monkey, swine and
      guinea pig acetylcholinesterase by MMB-4: a modified kinetic approach.
PG  - 231-7
LID - 10.1016/j.taap.2010.09.021 [doi]
AB  - Treatment of poisoning by highly toxic organophosphorus compounds (OP, nerve
      agents) is a continuous challenge. Standard treatment with atropine and a
      clinically used oxime, obidoxime or pralidoxime is inadequate against various
      nerve agents. For ethical reasons testing of oxime efficacy has to be performed
      in animals. Now, it was tempting to investigate the reactivation kinetics of
      MMB-4, a candidate oxime to replace pralidoxime, with nerve agent-inhibited
      acetylcholinesterase (AChE) from human and animal origin in order to provide a
      kinetic basis for the proper assessment of in vivo data. By applying a modified
      kinetic approach, allowing the use of necessary high MMB-4 concentrations, it was
      possible to determine the reactivation constants with sarin-, cyclosarin-, VX-,
      VR- and tabun-inhibited AChE. MMB-4 exhibited a high reactivity and low affinity 
      towards OP-inhibited AChE, except of tabun-inhibited enzyme where MMB-4 had an
      extremely low reactivity. Species differences between human and animal AChE were 
      low (Cynomolgus) to moderate (swine, guinea pig). Due to the high reactivity of
      MMB-4 a rapid reactivation of inhibited AChE can be anticipated at adequate oxime
      concentrations which are substantially higher compared to HI-6. Additional
      studies are necessary to determine the in vivo toxicity, tolerability and
      pharmacokinetics of MMB-4 in humans in order to enable a proper assessment of the
      value of this oxime as an antidote against nerve agent poisoning.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Worek, Franz
AU  - Worek F
AD  - Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937 
      Munich, Germany. franzworek@bundeswehr.org
FAU - Wille, Timo
AU  - Wille T
FAU - Aurbek, Nadine
AU  - Aurbek N
FAU - Eyer, Peter
AU  - Eyer P
FAU - Thiermann, Horst
AU  - Thiermann H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101001
PL  - United States
TA  - Toxicol Appl Pharmacol
JT  - Toxicology and applied pharmacology
JID - 0416575
RN  - 0 (Chemical Warfare Agents)
RN  - 0 (Cholinesterase Inhibitors)
RN  - 0 (Cholinesterase Reactivators)
RN  - 0 (Organophosphorus Compounds)
RN  - 0 (Oximes)
RN  - 61444-84-6 (N,N'-monomethylenebis(pyridiniumaldoxime))
RN  - EC 3.1.1.7 (Acetylcholinesterase)
SB  - IM
MH  - Acetylcholinesterase
MH  - Animals
MH  - Chemical Warfare Agents/toxicity
MH  - Cholinesterase Inhibitors/*toxicity
MH  - Cholinesterase Reactivators/*pharmacology
MH  - Guinea Pigs
MH  - Humans
MH  - Macaca fascicularis
MH  - Organophosphorus Compounds/*toxicity
MH  - Oximes/*pharmacology
MH  - Swine
EDAT- 2010/10/05 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/10/05 06:00
PHST- 2010/08/26 00:00 [received]
PHST- 2010/09/20 00:00 [revised]
PHST- 2010/09/23 00:00 [accepted]
PHST- 2010/10/05 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S0041-008X(10)00363-7 [pii]
AID - 10.1016/j.taap.2010.09.021 [doi]
PST - ppublish
SO  - Toxicol Appl Pharmacol. 2010 Dec 15;249(3):231-7. doi:
      10.1016/j.taap.2010.09.021. Epub 2010 Oct 1.


PMID- 20887681
OWN - NLM
STAT- MEDLINE
DCOM- 20110623
LR  - 20211203
IS  - 1555-3892 (Electronic)
IS  - 0963-6897 (Linking)
VI  - 20
IP  - 1
DP  - 2011
TI  - Induced pluripotent stem (iPS) cell research overview.
PG  - 15-9
LID - 10.3727/096368910X532828 [doi]
AB  - Stem cells are capable of self-renewal and differentiation into a wide range of
      cell types with multiple clinical therapeutic applications. The two most
      important issues associated with embryonic stem (ES) cells are immune rejection
      and medical ethics. In 2006, induced pluripotent (iPS) cells were generated from 
      somatic cells via the introduction of four transcriptional factors: OCT4, SOX2,
      c-MYC, and KLF4. Researchers found that iPS cell morphology, proliferation,
      surface antigens, gene expression, telomerase activity, and the epigenetic status
      of pluripotent cell-specific genes were similar to the same characteristics in ES
      cells. iPS cells are capable of overcoming hurdles associated with ES cells due
      to their generation from mature somatic cells (e.g., fibroblasts). For this
      reason, iPS cells are considered an increasingly important cell therapy
      technology. iPS cell production entails the use of retroviruses, lentiviruses,
      adenoviruses, plasmid transfections, transposons, or recombinant proteins. In
      this article we discuss the advantages and limitations of each strategy and
      address issues associated with clinical trials, including the potential for liver
      tumor formation and low generation efficiency.
FAU - Liu, Shih-Ping
AU  - Liu SP
AD  - Center for Neuropsychiatry, China Medical University and Hospital, Taichung,
      Taiwan.
FAU - Fu, Ru-Huei
AU  - Fu RH
FAU - Huang, Yu-Chuen
AU  - Huang YC
FAU - Chen, Shih-Yin
AU  - Chen SY
FAU - Chien, Ying-Jiun
AU  - Chien YJ
FAU - Hsu, Chien Yu
AU  - Hsu CY
FAU - Tsai, Chang-Hai
AU  - Tsai CH
FAU - Shyu, Woei-Cherng
AU  - Shyu WC
FAU - Lin, Shinn-Zong
AU  - Lin SZ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100930
PL  - United States
TA  - Cell Transplant
JT  - Cell transplantation
JID - 9208854
RN  - 0 (KLF4 protein, human)
RN  - 0 (Klf4 protein, mouse)
RN  - 0 (Kruppel-Like Factor 4)
RN  - 0 (Kruppel-Like Transcription Factors)
RN  - 0 (MicroRNAs)
RN  - 0 (Octamer Transcription Factor-3)
RN  - 0 (POU5F1 protein, human)
RN  - 0 (Proto-Oncogene Proteins c-myc)
RN  - 0 (SOX2 protein, human)
RN  - 0 (SOXB1 Transcription Factors)
SB  - IM
MH  - Animals
MH  - Embryonic Stem Cells/cytology
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*cytology/metabolism
MH  - Kruppel-Like Factor 4
MH  - Kruppel-Like Transcription Factors/genetics/metabolism
MH  - Mice
MH  - MicroRNAs/genetics/metabolism
MH  - Octamer Transcription Factor-3/genetics/metabolism
MH  - Plasmids/genetics/metabolism
MH  - Proto-Oncogene Proteins c-myc/genetics/metabolism
MH  - SOXB1 Transcription Factors/genetics/metabolism
MH  - Viruses/genetics/metabolism
EDAT- 2010/10/05 06:00
MHDA- 2011/06/24 06:00
CRDT- 2010/10/05 06:00
PHST- 2010/10/05 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2011/06/24 06:00 [medline]
AID - ct2309liu [pii]
AID - 10.3727/096368910X532828 [doi]
PST - ppublish
SO  - Cell Transplant. 2011;20(1):15-9. doi: 10.3727/096368910X532828. Epub 2010 Sep
      30.


PMID- 20887569
OWN - NLM
STAT- MEDLINE
DCOM- 20110113
LR  - 20101004
IS  - 1465-3362 (Electronic)
IS  - 0959-5236 (Linking)
VI  - 29
IP  - 5
DP  - 2010 Sep
TI  - Forming a national multicentre collaboration to conduct clinical trials:
      increasing high-quality research in the drug and alcohol field.
PG  - 469-74
LID - 10.1111/j.1465-3362.2009.00166.x [doi]
AB  - ISSUES: There is a shortage of high-quality intervention-based evidence in the
      drug and alcohol misuse field. That is, evidence based on replicated effects
      using rigorous methodology, to establish a causal knowledge base around ethical, 
      cost-effective methods relevant to clinical practice. The knowledge base in this 
      field is limited participant recruitment challenges; difficulty generalizing
      results from single-centre studies; lack of research culture; issues in managing 
      research teams; incentives for descriptive research; and limited expertise in
      research design and working in multidisciplinary teams. APPROACH: An Australian
      national multicentre collaboration is proposed to overcome these barriers, and
      reduce the burden of drug and alcohol misuse by increasing the number of
      high-quality clinical trials in this field. It would involve: selecting a
      representative sample of centres nation-wide with expertise in specific drug and 
      alcohol issues; creating an expert multidisciplinary team to facilitate clinical 
      trials; simultaneous recruitment and implementation of clinical trials across
      centres; establishing a virtual infrastructure; forming an independent
      data-integrity and methodology review panel; and attracting and allocating
      funding for clinical trials. IMPLICATIONS: The ability to allocate funding, the
      involvement of multidisciplinary experts in drug and alcohol research, and the
      establishment of infrastructure and procedures are likely to result in the
      national multicentre group's capacity to prescribe the type of research conducted
      under its auspices. CONCLUSION: The proposed initiative is likely to increase the
      volume of high-quality clinical trials in the Australian drug and alcohol field, 
      a key step towards reducing the burden of drug and alcohol misuse.
FAU - Sanson-Fisher, Rob
AU  - Sanson-Fisher R
AD  - Priority Research Centre for Health Behaviour, School of Medicine and Public
      Health, Faculty of Health, University of Newcastle, Newcastle, Australia.
      rob.sanson-fisher@newcastle.edu.au
FAU - Brand, Matthew
AU  - Brand M
FAU - Shakeshaft, Anthony
AU  - Shakeshaft A
FAU - Haber, Paul
AU  - Haber P
FAU - Day, Carolyn
AU  - Day C
FAU - Conigrave, Katherine
AU  - Conigrave K
FAU - Mattick, Richard
AU  - Mattick R
FAU - Lintzeris, Nicholas
AU  - Lintzeris N
FAU - Teesson, Maree
AU  - Teesson M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Drug Alcohol Rev
JT  - Drug and alcohol review
JID - 9015440
SB  - IM
MH  - Alcoholism/rehabilitation
MH  - Australia
MH  - Clinical Trials as Topic/economics/*methods/standards
MH  - Cooperative Behavior
MH  - Evidence-Based Medicine
MH  - Humans
MH  - Multicenter Studies as Topic/*methods/standards
MH  - Research Support as Topic
MH  - Substance-Related Disorders/*rehabilitation
EDAT- 2010/10/05 06:00
MHDA- 2011/01/14 06:00
CRDT- 2010/10/05 06:00
PHST- 2010/10/05 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2011/01/14 06:00 [medline]
AID - DAR166 [pii]
AID - 10.1111/j.1465-3362.2009.00166.x [doi]
PST - ppublish
SO  - Drug Alcohol Rev. 2010 Sep;29(5):469-74. doi: 10.1111/j.1465-3362.2009.00166.x.


PMID- 20887501
OWN - NLM
STAT- MEDLINE
DCOM- 20110125
LR  - 20220409
IS  - 1743-7563 (Electronic)
IS  - 1743-7555 (Linking)
VI  - 6
IP  - 3
DP  - 2010 Sep
TI  - What is the meaning of palliative care in the Asia-Pacific region?
PG  - 197-202
LID - 10.1111/j.1743-7563.2010.01315.x [doi]
AB  - This paper describes the preliminary work required to understand cultural
      differences in palliative care in the United Kingdom and three countries in the
      Asia-Pacific region, in preparation for a cross-country study. The study is
      intended to address cultural understandings of palliative care, the role of the
      family in end of life care, what constitutes good care and the ethical issues in 
      each country. Suggestions are then made to shape the scope of the study and to be
      considered as outcomes to improve care of the dying in these countries. It is
      anticipated that the method used to achieve consensus on cross-country palliative
      care issues will be both qualitative and quantitative. Identifying key priorities
      in the delivery and quality measures of palliative care will involve participants
      in focus groups, a Delphi survey and in the development of clinical indicators
      towards creating standards of palliative care common to the Asian Pacific region.
FAU - O'Connor, Margaret
AU  - O'Connor M
AD  - Palliative Care Research Team, School of Nursing and Midwifery, Monash University
      Australia, Frankston, Victoria, Australia. margaret.oconnor@med.monash.edu.au
FAU - O'Brien, Anthony Paul
AU  - O'Brien AP
FAU - Griffiths, Debra
AU  - Griffiths D
FAU - Poon, Edward
AU  - Poon E
FAU - Chin, Jacqueline
AU  - Chin J
FAU - Payne, Sheila
AU  - Payne S
FAU - Nordin, Rusli
AU  - Nordin R
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Asia Pac J Clin Oncol
JT  - Asia-Pacific journal of clinical oncology
JID - 101241430
SB  - IM
MH  - Australia
MH  - *Cultural Characteristics
MH  - Humans
MH  - Malaysia
MH  - *Palliative Care/psychology
MH  - Singapore
MH  - United Kingdom
EDAT- 2010/10/05 06:00
MHDA- 2011/01/28 06:00
CRDT- 2010/10/05 06:00
PHST- 2010/10/05 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2011/01/28 06:00 [medline]
AID - AJCO1315 [pii]
AID - 10.1111/j.1743-7563.2010.01315.x [doi]
PST - ppublish
SO  - Asia Pac J Clin Oncol. 2010 Sep;6(3):197-202. doi:
      10.1111/j.1743-7563.2010.01315.x.


PMID- 20887222
OWN - NLM
STAT- MEDLINE
DCOM- 20101101
LR  - 20101004
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Linking)
VI  - 202 Suppl 3
DP  - 2010 Nov 1
TI  - Natural resistance to HIV infection: lessons learned from HIV-exposed uninfected 
      individuals.
PG  - S345-50
LID - 10.1086/655973 [doi]
AB  - We explored potential mechanisms of resistance to human immunodeficiency virus
      type 1 (HIV-1) infection in different groups of uninfected individuals exposed by
      systemic or mucosal routes: intravascular drug users in Vietnam and spouses of
      HIV-infected individuals in Cambodia and Central African Republic. Our main
      findings were reduced susceptibility of peripheral blood mononuclear cells to
      HIV-1 infection in vitro, associated with low levels of CD4+ T cell activation in
      vivo and/or cell restriction of viral replication, and enhanced natural killer
      cell activity, associated with increased ratios of activating to inhibitory
      natural killer cell receptors. These results support a contribution of innate
      responses to resistance against HIV-1 infection. Scientific and ethical issues
      encountered during research in exposed uninfected subjects must be considered.
FAU - Pancino, Gianfranco
AU  - Pancino G
AD  - Institut Pasteur, Unite de Regulation des Infections Retrovirales, Paris, France.
      gianfranco.pancino@pasteur.fr
FAU - Saez-Cirion, Asier
AU  - Saez-Cirion A
FAU - Scott-Algara, Daniel
AU  - Scott-Algara D
FAU - Paul, Pascale
AU  - Paul P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
SB  - IM
MH  - Cambodia
MH  - Central African Republic
MH  - Female
MH  - HIV Infections/*immunology
MH  - HIV-1/*immunology
MH  - Humans
MH  - *Immunity, Innate
MH  - Killer Cells, Natural/immunology
MH  - Leukocytes, Mononuclear/*immunology/*virology
MH  - Lymphocyte Activation
MH  - Male
MH  - Vietnam
EDAT- 2010/10/05 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/10/05 06:00
PHST- 2010/10/05 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - 10.1086/655973 [doi]
PST - ppublish
SO  - J Infect Dis. 2010 Nov 1;202 Suppl 3:S345-50. doi: 10.1086/655973.


PMID- 20886914
OWN - NLM
STAT- MEDLINE
DCOM- 20110429
LR  - 20101004
IS  - 1132-1989 (Print)
IS  - 1132-1989 (Linking)
VI  - 21
IP  - 72
DP  - 2010 May-Aug
TI  - [Ethical problems in the selection of embryos with therapeutic usefulness].
PG  - 231-42
AB  - The first saviour sibling produced entirely in Spain was born in Hospital Virgen 
      del Rocio of Seville in October 2008. The consequente mass media coverage has
      unleashed multiple requests for similar treatments to be carried on throughout
      the country. The process, its methodology and efficiency are revised. Their
      anthropological, ethical and deontological foundations are explored in order to
      assess their fulfillment. Umbilical cord banking blood is proposed as an
      alternative.
FAU - Collazo Chao, Eliseo
AU  - Collazo Chao E
AD  - Unidad de Atencion al Pie Diabetico e Insuficiencia Venosa Cronica, Hospital
      Universitario Reina Sofia, Cordoba. ecollazo@comcordoba.com
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Problemas eticos en la seleccion de embriones con finalidad terapeutica.
PL  - Spain
TA  - Cuad Bioet
JT  - Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y
      Etica Medica
JID - 101312976
SB  - IM
MH  - Embryo Disposition/*ethics/legislation & jurisprudence
MH  - Humans
MH  - Spain
MH  - Therapeutics/ethics
EDAT- 2010/10/05 06:00
MHDA- 2011/04/30 06:00
CRDT- 2010/10/05 06:00
PHST- 2009/07/06 00:00 [received]
PHST- 2010/03/19 00:00 [accepted]
PHST- 2010/10/05 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2011/04/30 06:00 [medline]
PST - ppublish
SO  - Cuad Bioet. 2010 May-Aug;21(72):231-42.


PMID- 20886912
OWN - NLM
STAT- MEDLINE
DCOM- 20110429
LR  - 20101004
IS  - 1132-1989 (Print)
IS  - 1132-1989 (Linking)
VI  - 21
IP  - 72
DP  - 2010 May-Aug
TI  - [Conscientious objection for health professionals in ethics and deontology].
PG  - 199-210
AB  - The main objective of this paper is to highlight the numerous conflicts enters
      the consciousness and the laws are becoming more frequent health professionals in
      daily clinical practice. Clarify and define concepts such as ''conscientious
      objection for health professionals, to avoid confusion with other terms. This is 
      work that aims to address the objection of conscience, not from the law but from 
      the ethics and deontology, reviewing existing regulations both internationally
      and nationally. In addition to complete the studio, in a last part we discuss the
      state of the ''conscientious objection'' tars the recent passage of the organic
      law 2 / 2010, 3 march, sexual and reproductive health and the interruption of
      pregnancy. As a final conclusion we can say that ''conscientious objection'' is
      recognized in international declarations and even in the european constitution.
      in spain, the code of ethics and medical ethics, is one of the places where the
      objection of conscience of health professionals has great development for years, 
      states that the doctor can refrain from the practice of certain professional acts
      such as abortion, in vitro fertilization or sterilization, if they are in
      contradiction with its ethical and scientific beliefs. Also recently, the general
      assembly of october 24, 2009, the central committee of ethics has made a
      declaration on ''conscientious objection'', insisting on its recognition.
      Finally, the organic law 2 / 2010, 3 march, sexual and reproductive health and
      the interruption of pregnancy, seems to be recognized ''the right to exercise
      conscientious objection'' of health professionals directly involved in the
      voluntary termination of pregnancy, after much discussion, but it is still early 
      to assess the implementation of this right because, until july 5, 2010, will come
      into force this law, what will the future that we clarify the development of this
      important right for health professionals.
FAU - Martinez Leon, Mercedes
AU  - Martinez Leon M
AD  - Comision de Etica y Deontologia del Colegio Oficial de Medicos de Valladolid,
      Area de Medicina Legal, Facultad de Medicina, Avda Ramon y Cajal 7,
      47005-Valladolid. legal@med.uva.es
FAU - Rabadan Jimenez, Jose
AU  - Rabadan Jimenez J
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - La objecion de conciencia de los profesionales sanitarios en la etica y
      deontologia.
PL  - Spain
TA  - Cuad Bioet
JT  - Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y
      Etica Medica
JID - 101312976
SB  - IM
MH  - Abortion, Induced/*ethics
MH  - Health Personnel/*ethics
MH  - Humans
MH  - Reproductive Medicine/*ethics
MH  - Spain
EDAT- 2010/10/05 06:00
MHDA- 2011/04/30 06:00
CRDT- 2010/10/05 06:00
PHST- 2009/12/07 00:00 [received]
PHST- 2010/05/01 00:00 [accepted]
PHST- 2010/10/05 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2011/04/30 06:00 [medline]
PST - ppublish
SO  - Cuad Bioet. 2010 May-Aug;21(72):199-210.


PMID- 20886910
OWN - NLM
STAT- MEDLINE
DCOM- 20110429
LR  - 20101004
IS  - 1132-1989 (Print)
IS  - 1132-1989 (Linking)
VI  - 21
IP  - 72
DP  - 2010 May-Aug
TI  - [Reviewing the so-called ''Living Will''].
PG  - 169-83
AB  - Cases like those of Terry Schiavo or Eluana Englaro have given rise to a lot of
      discussions at all levels. What both of them have in common is that, beyond the
      reasons given for terminating their lives and the methods used to achieve it,
      their destiny was not decided by them. This has resulted in a lot of heated
      debates in the public sphere as well as in the juridical, political, medical and 
      speculative-ethical fields. Many people have been led to ask themselves:
      ''Wouldn't a better solution have been found if the desire of both persons had
      been known without any shadow of doubt, in the case that they had foreseen the
      situation in which they eventually found themselves in?''. The concept of the
      so-called Living Will appears to be a good solution for such cases. However, in
      the years in which attempts have been made to introduce this into practice,
      important ethical questions regarding end-of-life situations have come up: Can
      everything in my life, including when and how I die, be part of a legacy? Is a
      person who enjoys good health in a position to autonomously determine how he
      would like to be treated if, in an uncertain future, he ends up in a situation
      where he is incapable of communicating his wishes? Is the ordinary citizen
      capable of domineering the multiplicity of treatments, diagnosis and prognosis
      which medical science has to offer? Is it the same thing to forego a complicated 
      treatment as to renounce artificial feeding and hydration? This article examines 
      all these arguments, offering at the same time the case for and the case against 
      the so-called Living Will.
FAU - Agulles Simo, Pau
AU  - Agulles Simo P
AD  - Pontificia Universita della Santa Croce, Piazza di Sant'Apollinare 49, 00186
      Roma, Italia. agulles@pusc.it
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Revisando el llamado ''Testamento Vital''.
PL  - Spain
TA  - Cuad Bioet
JT  - Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y
      Etica Medica
JID - 101312976
SB  - IM
MH  - Advance Directives
MH  - Humans
MH  - Life Support Care
MH  - *Living Wills
MH  - Terminology as Topic
EDAT- 2010/10/05 06:00
MHDA- 2011/04/30 06:00
CRDT- 2010/10/05 06:00
PHST- 2010/02/06 00:00 [received]
PHST- 2010/07/19 00:00 [accepted]
PHST- 2010/10/05 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2011/04/30 06:00 [medline]
PST - ppublish
SO  - Cuad Bioet. 2010 May-Aug;21(72):169-83.


PMID- 20886909
OWN - NLM
STAT- MEDLINE
DCOM- 20110429
LR  - 20101004
IS  - 1132-1989 (Print)
IS  - 1132-1989 (Linking)
VI  - 21
IP  - 72
DP  - 2010 May-Aug
TI  - [The costs of altruism in organ donation case analysis].
PG  - 157-67
AB  - Three main assumptions were considered for the structure of donation programs
      during the decade of the sixties: the first states that people, through altruism,
      would feel committed with the affected and therefore incentivized to donate. The 
      second one states that the human body can not be valued in mercantile terms;
      therefore organ donation should not be done free of any charges. The last one
      states donation does not represent any type of harm or damage for the donor.
      Today, more tan four decades away from their instauration, these three
      assumptions have been violated and modified due to the way in which they were
      socialized through the donation protocols. Altruism did not seem to be as
      generalized as expected, and organ commerce has already gone beyond the
      legislative frameworks that intended to prevent it; one example is the case of
      India. In this paper we analyze--through two objectives--the repercussions and
      impact that took effect in four cases registered in the National Institute of
      Cardiology (Instituto Nacional de Cardiologia) "Ignacio Chavez" in Mexico City.
      First objective: to describe the economical costs that the altruism-based
      donation protocol caused on the participant families. Second objective: to
      reflect on other costs that affected donators due to organ donation. It was found
      on the reviewed cases that repercussions can go beyond the economical issues;
      labor related, emotional and ethical repercussions were found too due to a
      undeniable sensation of reification that donors experience in view of the
      mechanization of the study protocol they undergo, specially when results are not 
      the optimum. We circumscribe this paper's analysis to living donors.
FAU - Netza Cardoso, Cruz
AU  - Netza Cardoso C
AD  - Universidad Nacional Autonoma de Mexico, Campo de Estudio Principal Bioetica,
      Distrito Federal, Mexico. philo_cruz@yahoo.com
FAU - Casas Martinez, Maria Luz Lina
AU  - Casas Martinez ML
FAU - Ramirez Garcia, Hugo
AU  - Ramirez Garcia H
LA  - spa
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - Los costos del altruismo en donacion de organos analisis de casos.
PL  - Spain
TA  - Cuad Bioet
JT  - Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y
      Etica Medica
JID - 101312976
SB  - IM
MH  - Adult
MH  - *Altruism
MH  - Female
MH  - Humans
MH  - Kidney Failure, Chronic/surgery
MH  - Kidney Transplantation/*economics
MH  - *Living Donors
MH  - Male
MH  - Tissue and Organ Procurement/*economics
EDAT- 2010/10/05 06:00
MHDA- 2011/04/30 06:00
CRDT- 2010/10/05 06:00
PHST- 2009/04/14 00:00 [received]
PHST- 2010/07/23 00:00 [accepted]
PHST- 2010/10/05 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2011/04/30 06:00 [medline]
PST - ppublish
SO  - Cuad Bioet. 2010 May-Aug;21(72):157-67.


PMID- 20886693
OWN - NLM
STAT- MEDLINE
DCOM- 20101102
LR  - 20171206
IS  - 0026-4075 (Print)
IS  - 0026-4075 (Linking)
VI  - 175
IP  - 9
DP  - 2010 Sep
TI  - RE: Ethical practice under fire: deployed physicians in the global war on
      terrorism, published in [Mil med 2009; 174(5): 441-7].
PG  - xii-xiii; author reply xiv
FAU - Lounsbury, Dave Edmond
AU  - Lounsbury DE
LA  - eng
PT  - Comment
PT  - Letter
PL  - England
TA  - Mil Med
JT  - Military medicine
JID - 2984771R
SB  - IM
CON - Mil Med. 2009 May;174(5):441-7. PMID: 20731272
MH  - *Ethics, Medical
MH  - Humans
MH  - Military Medicine/*ethics
MH  - *Military Personnel
MH  - *Physician's Role
MH  - Physicians/*ethics
MH  - *Terrorism
MH  - Torture/*ethics
MH  - United States
MH  - *Warfare
EDAT- 2010/10/05 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/10/02 06:00
PHST- 2010/10/02 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
PST - ppublish
SO  - Mil Med. 2010 Sep;175(9):xii-xiii; author reply xiv.


PMID- 20886692
OWN - NLM
STAT- MEDLINE
DCOM- 20101102
LR  - 20171206
IS  - 0026-4075 (Print)
IS  - 0026-4075 (Linking)
VI  - 175
IP  - 9
DP  - 2010 Sep
TI  - RE: Ethical practice under fire: deployed physicians in the global war on
      terrorism, published in [Mil Med 2009; 174(5): 441-7].
PG  - xii
FAU - Ligtenstein, David A
AU  - Ligtenstein DA
LA  - eng
PT  - Comment
PT  - Letter
PL  - England
TA  - Mil Med
JT  - Military medicine
JID - 2984771R
SB  - IM
CON - Mil Med. 2009 May;174(5):441-7. PMID: 20731272
MH  - *Ethics, Medical
MH  - Humans
MH  - Military Medicine/*ethics
MH  - *Military Personnel
MH  - *Physician's Role
MH  - Physicians/*ethics
MH  - *Terrorism
MH  - Torture/*ethics
MH  - United States
MH  - *Warfare
EDAT- 2010/10/05 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/10/02 06:00
PHST- 2010/10/02 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
PST - ppublish
SO  - Mil Med. 2010 Sep;175(9):xii.


PMID- 20886536
OWN - NLM
STAT- MEDLINE
DCOM- 20110630
LR  - 20211020
IS  - 1098-2302 (Electronic)
IS  - 0012-1630 (Linking)
VI  - 53
IP  - 2
DP  - 2011 Mar
TI  - Ontogenetic differences in adolescent and adult C57BL/6J and DBA/2J mice:
      anxiety-like, locomotor, and consummatory behaviors.
PG  - 141-56
LID - 10.1002/dev.20501 [doi]
AB  - Adolescence is a highly conserved period during which mammals undergo a number of
      hormonal, biological, and behavioral changes [Spear [2000] Neurosci. Biobehav.
      Rev. 24: 417-463]. Ethical constraints limit the research that can be done in
      human adolescents. Rodents provide a useful model of at least some of the
      features of adolescence, including increases in body growth, differences in
      sleep/wake, and eating patterns, as well as differences in risk-taking, novelty
      seeking, and exploratory behaviors. Much of the available developmental research 
      has utilized rats; however, the use of inbred mouse strains provides a unique
      means to assess the genetic factors involved in behavioral differences during
      adolescence. We assessed differences between adults and adolescents in
      anxiety-like, locomotor, and consummatory behaviors using two commonly used
      inbred strains of mice, the DBA/2J and C57BL/6J strains. Age and
      genotype-dependent differences were found in all three behaviors measured,
      suggesting both factors are important determinants of behavior in mice.
CI  - Copyright (c) 2010 Wiley Periodicals, Inc.
FAU - Moore, Eileen M
AU  - Moore EM
AD  - Department of Psychology, Indiana University-Purdue University, 402 N Blackford
      St, LD 124, Indianapolis, IN 46202, USA.
FAU - Linsenbardt, David N
AU  - Linsenbardt DN
FAU - Melon, Laverne C
AU  - Melon LC
FAU - Boehm, Stephen L 2nd
AU  - Boehm SL 2nd
LA  - eng
GR  - R01 AA016789/AA/NIAAA NIH HHS/United States
GR  - AA018910/AA/NIAAA NIH HHS/United States
GR  - AA015434/AA/NIAAA NIH HHS/United States
GR  - F31 AA018910/AA/NIAAA NIH HHS/United States
GR  - K01 AA015434/AA/NIAAA NIH HHS/United States
GR  - AA016789/AA/NIAAA NIH HHS/United States
GR  - AA07462/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20100930
PL  - United States
TA  - Dev Psychobiol
JT  - Developmental psychobiology
JID - 0164074
SB  - IM
MH  - Age Factors
MH  - Analysis of Variance
MH  - Animals
MH  - Anxiety/*genetics
MH  - Behavior, Animal/*physiology
MH  - Body Weight/genetics
MH  - Drinking/*genetics
MH  - Drinking Behavior/physiology
MH  - Eating/*genetics
MH  - Feeding Behavior/physiology
MH  - Female
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred DBA
MH  - Motor Activity/*genetics
MH  - Species Specificity
PMC - PMC3375063
MID - NIHMS383053
EDAT- 2010/10/05 06:00
MHDA- 2011/07/01 06:00
CRDT- 2010/10/02 06:00
PHST- 2009/04/05 00:00 [received]
PHST- 2010/08/16 00:00 [revised]
PHST- 2010/08/17 00:00 [accepted]
PHST- 2010/10/02 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2011/07/01 06:00 [medline]
AID - 10.1002/dev.20501 [doi]
PST - ppublish
SO  - Dev Psychobiol. 2011 Mar;53(2):141-56. doi: 10.1002/dev.20501. Epub 2010 Sep 30.


PMID- 20886390
OWN - NLM
STAT- MEDLINE
DCOM- 20110114
LR  - 20121115
IS  - 2040-3445 (Electronic)
IS  - 1464-8431 (Linking)
VI  - 12
IP  - 5
DP  - 2010 Oct
TI  - The ethics of gene therapy: balancing the risks.
PG  - 578-85
AB  - Gene therapy research is characterized by heightened uncertainty about the risks 
      associated with the complex products involved, particularly the risk of
      genotoxicity. Recognizing that uncertainty concerning risks is inescapable in
      first-in-human clinical trials of gene therapy, decisions on how to balance the
      risks nevertheless must be made. Ethics can facilitate translational progress by,
      first, evaluating decision-making processes during risk assessment; and second,
      focusing on questions that require a degree of subjective judgement. Such
      assessments include determining the level of risk that is acceptable in trials,
      the category of patients that should be exposed to the risks, and the level of
      certainty with respect to risk that is required for both researchers and
      participants to make decisions. Analysis of these issues is affected by the
      burden of illness, existing treatment alternatives and the possible benefits of
      gene therapy. Patients' attitudes and experiences in this regard can reasonably
      inform the decision-making of researchers. Reflecting upon the approaches used to
      balance risks and possible benefits in gene therapy trials may improve
      decision-making processes across the spectrum of decisions that are made from the
      initial conception of a study up to decisions by research participants about
      consent. This manner of reflection facilitates the advancement of science, while 
      protecting the welfare of research participants.
FAU - Deakin, Claire T
AU  - Deakin CT
AD  - Children's Medical Research Institute, Gene Therapy Research Unit, 214 Hawkesbury
      Road, Australia.
FAU - Alexander, Ian E
AU  - Alexander IE
FAU - Kerridge, Ian
AU  - Kerridge I
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Curr Opin Mol Ther
JT  - Current opinion in molecular therapeutics
JID - 100891485
SB  - IM
MH  - Decision Making
MH  - Genetic Therapy/*ethics
MH  - Humans
MH  - Risk Assessment/*methods
EDAT- 2010/10/05 06:00
MHDA- 2011/01/15 06:00
CRDT- 2010/10/02 06:00
PHST- 2010/10/02 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2011/01/15 06:00 [medline]
PST - ppublish
SO  - Curr Opin Mol Ther. 2010 Oct;12(5):578-85.


PMID- 20886244
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20110128
IS  - 0942-0940 (Electronic)
IS  - 0001-6268 (Linking)
VI  - 153
IP  - 2
DP  - 2011 Feb
TI  - New model of reperfused stroke by occlusion of the anterior cerebral artery in
      baboons.
PG  - 327-31
LID - 10.1007/s00701-010-0816-1 [doi]
AB  - BACKGROUND: The understanding of stroke has been greatly enhanced by studies
      employing nonhuman primate models of focal ischemia. However, devastating
      neurological disability in previously described stroke models has led to ethical 
      concerns and difficulty achieving prolonged survival for the evaluation of
      long-term outcome. We determined if reversible occlusion of the anterior cerebral
      artery in baboons would produce a small infarct with minimal neurological
      impairment. METHODS: In six baboons, anesthetized with isoflurane, Guglielmi
      coils were placed by endovascular technique in the anterior cerebral artery. In
      two baboons coils were placed for 3 h at the proximal A2 segment. In four baboons
      coils were placed at the junction of the A2 and A3 segments of the anterior
      cerebral artery for 1.5 h (n = 2) or 3 h (n = 2). The coils were removed and
      reperfusion confirmed by angiography. Thereafter, the animals were awakened from 
      anesthesia and brain MRI studies were performed at 1 week. RESULTS: Baboons
      awakened with minimal neurological impairment. Animals subject to occlusion at
      the proximal A2 segment and animals subject to 1.5 h of occlusion at the junction
      of A2 and A3 had no infarct. Animals with 3-h occlusion at the junction of A2 and
      A3 showed infarcts of 3.5% and 2.8% of cerebral hemispheres. CONCLUSIONS: This
      study indicates that reversible anterior cerebral artery occlusion may provide a 
      new humane animal model for small stroke and limited neurological deficit.
FAU - Schwartz, Arthur E
AU  - Schwartz AE
AD  - Department of Anesthesiology, The Mount Sinai School of Medicine, New York, NY
      10029, USA. arthur.schwartz@mountsinai.org
FAU - Pile-Spellman, John
AU  - Pile-Spellman J
LA  - eng
PT  - Journal Article
DEP - 20101002
PL  - Austria
TA  - Acta Neurochir (Wien)
JT  - Acta neurochirurgica
JID - 0151000
SB  - IM
MH  - Animals
MH  - Anterior Cerebral Artery/pathology/*physiopathology
MH  - Blood Vessel Prosthesis Implantation/adverse effects/instrumentation/methods
MH  - *Disease Models, Animal
MH  - Humans
MH  - Infarction, Anterior Cerebral Artery/*etiology
MH  - Intracranial Embolism/etiology
MH  - Male
MH  - Papio
MH  - Reperfusion Injury/*etiology
EDAT- 2010/10/05 06:00
MHDA- 2011/12/13 00:00
CRDT- 2010/10/02 06:00
PHST- 2010/07/11 00:00 [received]
PHST- 2010/09/20 00:00 [accepted]
PHST- 2010/10/02 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/s00701-010-0816-1 [doi]
PST - ppublish
SO  - Acta Neurochir (Wien). 2011 Feb;153(2):327-31. doi: 10.1007/s00701-010-0816-1.
      Epub 2010 Oct 2.


PMID- 20886241
OWN - NLM
STAT- MEDLINE
DCOM- 20110401
LR  - 20211020
IS  - 1438-8359 (Electronic)
IS  - 0913-8668 (Linking)
VI  - 24
IP  - 6
DP  - 2010 Dec
TI  - The LMA CTrach in morbidly obese and lean patients undergoing gynecological
      procedures: a comparative study.
PG  - 849-53
LID - 10.1007/s00540-010-1022-2 [doi]
AB  - PURPOSE: The tracheas of obese patients may be more difficult to intubate than
      those of normal-weight patients. The aim of this study was to compare the airway 
      management quality in morbidly obese and lean patients with use of the LMA
      CTrach. METHODS: After Ethics Committee approval, 60 adult patients (30 morbidly 
      obese patients with body mass index >40 kg/m(2) and 30 lean patients with body
      mass index <30 kg/m(2)) scheduled to undergo gynecological surgery were enrolled 
      in this prospective study. The induction of anesthesia was standardized using
      propofol, fentanyl, and rocuronium. Ventilation and intubation success rates,
      time taken to achieve successful ventilation, and intubation through the CTrach
      and airway complications were recorded. RESULTS: The CTrach was successfully
      inserted and adequate ventilation through the CTrach was achieved in 59 patients 
      (98%). Only 1 patient in the lean group was not able to ventilate through the
      CTrach. We were successful in endotracheal intubation, either under vision or
      blind, in 56 patients (93%). We were able to view the larynx in 51 patients
      (85%). Total intubation time was significantly longer in morbidly obese patients,
      69 (311) s, than in lean patients, 33 (107) s [median (range)] (P < 0.001).
      CONCLUSIONS: We concluded that the time to intubate the trachea in obese patients
      was significantly longer than in lean patients when the LMA CTrach was used.
FAU - Yildiz, Tulay Sahin
AU  - Yildiz TS
AD  - Department of Anaesthesiology, Medical Faculty, University of Kocaeli, Kocaeli,
      Turkey. tsyildiz@yahoo.com
FAU - Ozdamar, Dilek
AU  - Ozdamar D
FAU - Arslan, Ipek
AU  - Arslan I
FAU - Solak, Mine
AU  - Solak M
FAU - Toker, Kamil
AU  - Toker K
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
DEP - 20101001
PL  - Japan
TA  - J Anesth
JT  - Journal of anesthesia
JID - 8905667
RN  - 0 (Hypnotics and Sedatives)
RN  - R60L0SM5BC (Midazolam)
SB  - IM
MH  - Adult
MH  - Body Mass Index
MH  - Female
MH  - *Gynecologic Surgical Procedures
MH  - Humans
MH  - Hypnotics and Sedatives
MH  - Intubation, Intratracheal
MH  - *Laryngeal Masks
MH  - Larynx/anatomy & histology/injuries
MH  - Midazolam
MH  - Middle Aged
MH  - Obesity, Morbid/*complications
MH  - Pain, Postoperative/epidemiology
MH  - Preanesthetic Medication
MH  - Prospective Studies
MH  - Respiration, Artificial
EDAT- 2010/10/05 06:00
MHDA- 2011/04/02 06:00
CRDT- 2010/10/02 06:00
PHST- 2010/02/09 00:00 [received]
PHST- 2010/09/03 00:00 [accepted]
PHST- 2010/10/02 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2011/04/02 06:00 [medline]
AID - 10.1007/s00540-010-1022-2 [doi]
PST - ppublish
SO  - J Anesth. 2010 Dec;24(6):849-53. doi: 10.1007/s00540-010-1022-2. Epub 2010 Oct 1.


PMID- 20885823
OWN - NLM
STAT- MEDLINE
DCOM- 20101110
LR  - 20160818
IS  - 0008-5286 (Print)
IS  - 0008-5286 (Linking)
VI  - 51
IP  - 7
DP  - 2010 Jul
TI  - An ethicist's commentary on whether the use of analgesia should be left to client
      discretion.
PG  - 686, 688
FAU - Rollin, Bernard E
AU  - Rollin BE
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Vet J
JT  - The Canadian veterinary journal = La revue veterinaire canadienne
JID - 0004653
RN  - 0 (Analgesics)
SB  - IM
MH  - Analgesia/*veterinary
MH  - Analgesics/*administration & dosage
MH  - Animals
MH  - *Decision Making
MH  - *Ethics, Professional
MH  - Humans
MH  - Pain/drug therapy/prevention & control/veterinary
MH  - Veterinary Medicine/methods/*standards
EDAT- 2010/10/05 06:00
MHDA- 2010/11/11 06:00
CRDT- 2010/10/02 06:00
PHST- 2010/10/02 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2010/11/11 06:00 [medline]
PST - ppublish
SO  - Can Vet J. 2010 Jul;51(7):686, 688.


PMID- 20885293
OWN - NLM
STAT- MEDLINE
DCOM- 20101109
LR  - 20220321
IS  - 1528-1175 (Electronic)
IS  - 0003-3022 (Linking)
VI  - 113
IP  - 5
DP  - 2010 Nov
TI  - Sugammadex and neostigmine dose-finding study for reversal of shallow residual
      neuromuscular block.
PG  - 1054-60
LID - 10.1097/ALN.0b013e3181f4182a [doi]
AB  - INTRODUCTION: Sugammadex effectively and rapidly reverses deep to moderate
      rocuronium-induced neuromuscular block. However, the required dose of sugammadex 
      for smaller degrees of residual block is unknown. Therefore we investigated the
      efficacy of sugammadex and neostigmine at a train-of-four (TOF) ratio of 0.5.
      METHODS: After ethics committee (Munich, Germany) approval and written informed
      consent were obtained, 99 patients were anesthetized with propofol, remifentanil,
      and rocuronium. Neuromuscular monitoring was performed by calibrated
      electromyography. At recovery of the TOF ratio to 0.5, patients randomly received
      sugammadex (0.0625, 0.125, 0.25, 0.5, or 1.0 mg/kg), neostigmine (5, 8, 15, 25,
      or 40 mug/kg), or saline. The time between study drug injection, at TOF ratio of 
      0.5, and postoperative TOF ratio of 0.9 was measured. The dose-response
      relationship was analyzed with a biexponential model using the dose as the
      independent variable and the logarithm of the recovery time as the dependent
      variable. Effective doses were interpolated from regression models. RESULTS:
      Sugammadex, 0.22 mg/kg, is able to reverse a TOF ratio of 0.5 to 0.9 or higher in
      an average time of 2 min. Within 5 min, 95% of patients reach this TOF ratio.
      Neostigmine, 34 mug/kg, is able to reverse a TOF ratio of 0.5 to 0.9 or higher
      within 5 min. No recurarization was observed. CONCLUSIONS: Sugammadex, 0.22
      mg/kg, and neostigmine, 34 mug/kg, effectively and comparably reverse a
      rocuronium-induced shallow residual neuromuscular block at a TOF ratio of 0.5.
FAU - Schaller, Stefan J
AU  - Schaller SJ
AD  - Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany.
FAU - Fink, Heidrun
AU  - Fink H
FAU - Ulm, Kurt
AU  - Ulm K
FAU - Blobner, Manfred
AU  - Blobner M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Anesthesiology
JT  - Anesthesiology
JID - 1300217
RN  - 0 (gamma-Cyclodextrins)
RN  - 361LPM2T56 (Sugammadex)
RN  - 3982TWQ96G (Neostigmine)
SB  - IM
CIN - Anesthesiology. 2010 Nov;113(5):1010-1. PMID: 20852409
MH  - Adult
MH  - *Anesthesia Recovery Period
MH  - Dose-Response Relationship, Drug
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Monitoring, Intraoperative/methods
MH  - Neostigmine/*administration & dosage
MH  - Neuromuscular Blockade/*methods
MH  - Sugammadex
MH  - gamma-Cyclodextrins/*administration & dosage
EDAT- 2010/10/05 06:00
MHDA- 2010/11/10 06:00
CRDT- 2010/10/02 06:00
PHST- 2010/10/02 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2010/11/10 06:00 [medline]
AID - 10.1097/ALN.0b013e3181f4182a [doi]
PST - ppublish
SO  - Anesthesiology. 2010 Nov;113(5):1054-60. doi: 10.1097/ALN.0b013e3181f4182a.


PMID- 20885016
OWN - NLM
STAT- MEDLINE
DCOM- 20110112
LR  - 20220331
IS  - 1734-1140 (Print)
IS  - 1734-1140 (Linking)
VI  - 62
IP  - 4
DP  - 2010 Jul-Aug
TI  - Pentazocine pretreatment suppresses fentanyl-induced cough.
PG  - 747-50
AB  - This study evaluated the effect of pentazocine pretreatment on fentanyl-induced
      cough. With ethics committee approval, 277 ASA I-II patients, aged between 19 and
      63 years, undergoing various elective surgeries during general anesthesia, were
      enrolled in this prospective, randomized, double-blind, placebo-controlled
      clinical trial. All patients were randomly assigned to one of three groups. Group
      I (n = 92) and Group II (n = 93) received normal saline, while Group III (n = 92)
      received pentazocine 0.5 mg.kg(-1) 5 min prior to receiving fentanyl, Patients
      belonging to Groups II and III were administered 2 mug/kg fentanyl intravenously 
      over 2 s after the first injection; Group I served as a negative control for
      fentanyl. Physiologic indicators such as heart rate (HR), non-invasive blood
      pressure (NBP) and pulse oximetry oxygen saturation (SpO(2)) of patients were
      recorded before giving pentazocine or normal saline 1 minute after fentanyl
      injections. The incidence of cough was recorded and graded as mild (1-2),
      moderate (3-5) and severe (> 5), depending on the number of coughs observed [13].
      The incidence of cough was 0%, 22.6% and 4.3% in Group I, Group II and Group III,
      respectively. There was no significant difference in SpO(2) for the duration of
      the trial among the three groups. Premedication with intravenous pentazocine can 
      minimize the incidence of fentanyl-induced cough and has no influence on blood
      pressure, heart rate, and SpO(2) compared with Group II.
FAU - Ai, Qing
AU  - Ai Q
AD  - Department of Anesthesiology, Affiliated Wuxi People's Hospital, Nanjing Medical 
      University, Wuxi City, 214000, PR China. aiqingbox@yahoo.com.cn
FAU - Hu, YiPing
AU  - Hu Y
FAU - Wang, YanJuan
AU  - Wang Y
FAU - Wu, ShuoXiong
AU  - Wu S
FAU - Qin, Zhong
AU  - Qin Z
FAU - Wang, Jun
AU  - Wang J
FAU - Wang, GuiLong
AU  - Wang G
FAU - Zhang, JianYu
AU  - Zhang J
FAU - An, MingHao
AU  - An M
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Switzerland
TA  - Pharmacol Rep
JT  - Pharmacological reports : PR
JID - 101234999
RN  - 0 (Anesthetics, Intravenous)
RN  - 0 (Narcotic Antagonists)
RN  - RP4A60D26L (Pentazocine)
RN  - UF599785JZ (Fentanyl)
SB  - IM
MH  - Adult
MH  - Anesthesia, General/methods
MH  - Anesthetics, Intravenous/*adverse effects/therapeutic use
MH  - Cough/chemically induced/*prevention & control
MH  - Double-Blind Method
MH  - Elective Surgical Procedures
MH  - Female
MH  - Fentanyl/*adverse effects/therapeutic use
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Narcotic Antagonists/therapeutic use
MH  - Pentazocine/*therapeutic use
MH  - Prospective Studies
MH  - Severity of Illness Index
MH  - Young Adult
EDAT- 2010/10/05 06:00
MHDA- 2011/01/13 06:00
CRDT- 2010/10/02 06:00
PHST- 2009/06/09 00:00 [received]
PHST- 2009/12/03 00:00 [revised]
PHST- 2010/10/02 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2011/01/13 06:00 [medline]
AID - S1734-1140(10)70333-9 [pii]
AID - 10.1016/s1734-1140(10)70333-9 [doi]
PST - ppublish
SO  - Pharmacol Rep. 2010 Jul-Aug;62(4):747-50. doi: 10.1016/s1734-1140(10)70333-9.


PMID- 20884914
OWN - NLM
STAT- MEDLINE
DCOM- 20110110
LR  - 20131121
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 257
IP  - 3
DP  - 2010 Dec
TI  - Role of breast MR imaging for predicting malignancy of histologically borderline 
      lesions diagnosed at core needle biopsy: prospective evaluation.
PG  - 653-61
LID - 10.1148/radiol.10100732 [doi]
AB  - PURPOSE: To prospectively determine the diagnostic performance of breast magnetic
      resonance (MR) imaging in predicting the malignancy of breast lesions classified 
      as borderline at core needle biopsy (CNB). MATERIALS AND METHODS: This
      prospective study was approved by the local ethics committee, and all patients
      provided written informed consent. Between February 2007 and October 2009, 193
      patients underwent ultrasonography (US)-guided CNB. Thirty-two lesions in 32
      patients were classified as "borderline" ("lesions of uncertain malignant
      potential" according to the United Kingdom National Health Service Breast
      Screening program or those that are "probably benign" according to the Breast
      Imaging Reporting and Data System [BI-RADS] lexicon) at pathologic examination
      and were evaluated. All 32 patients underwent contrast agent-enhanced breast MR
      imaging 1-3 weeks after CNB; surgical biopsy was performed within 60 days of MR
      imaging. Results were compared with histologic findings. Sensitivity,
      specificity, accuracy, and positive and negative predictive values were
      calculated. RESULTS: Findings from surgical biopsy confirmed the diagnosis of
      seven atypical ductal hyperplasia lesions, four atypical lobular hyperplasia
      (ALH) lesions, five papillary lesions, two fibroepithelial lesions, three radial 
      scars, three lobular carcinomas in situ, three ductal carcinomas in situ (DCIS), 
      four invasive ductal carcinomas, and one invasive lobular carcinoma. With regard 
      to malignancy, breast MR imaging helped correctly classify 22 of the 32 lesions
      as negative and seven as positive. Two of the lesions confirmed to be ALH were
      incorrectly classified as suspicious (BI-RADS category IV; false-positive
      finding), whereas one small DCIS was incorrectly classified as nonsuspicious
      (BI-RADS category II; false-negative finding). The sensitivity, specificity,
      accuracy, and positive and negative predictive values for the correct
      demonstration of malignancy at MR imaging were 88% (seven of eight lesions), 92% 
      (22 of 24 lesions), 91% (29 of 32 lesions), 78% (seven of nine lesions), and 96% 
      (22 of 23 lesions), respectively. CONCLUSION: Breast MR imaging can improve the
      evaluation of lesions classified as borderline at CNB. In cases of nonsuspicious 
      enhancement or no enhancement at breast MR imaging, follow-up rather than
      surgical biopsy might be performed.
CI  - (c) RSNA, 2010.
FAU - Pediconi, Federica
AU  - Pediconi F
AD  - Department of Radiological Sciences, University of Rome La Sapienza, V.le Regina 
      Elena 324, 00161 Rome, Italy. federica.pediconi@uniroma1.it
FAU - Padula, Simona
AU  - Padula S
FAU - Dominelli, Valeria
AU  - Dominelli V
FAU - Luciani, MariaLaura
AU  - Luciani M
FAU - Telesca, Marianna
AU  - Telesca M
FAU - Casali, Valeria
AU  - Casali V
FAU - Kirchin, Miles A
AU  - Kirchin MA
FAU - Passariello, Roberto
AU  - Passariello R
FAU - Catalano, Carlo
AU  - Catalano C
LA  - eng
PT  - Journal Article
DEP - 20100930
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 15G12L5X8K (gadobenic acid)
RN  - 6HG8UB2MUY (Meglumine)
SB  - IM
MH  - Adult
MH  - *Biopsy, Needle
MH  - Breast Neoplasms/*pathology
MH  - Contrast Media/administration & dosage
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Meglumine/administration & dosage/analogs & derivatives
MH  - Middle Aged
MH  - Organometallic Compounds/administration & dosage
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Sensitivity and Specificity
MH  - Ultrasonography, Interventional
EDAT- 2010/10/05 06:00
MHDA- 2011/01/11 06:00
CRDT- 2010/10/02 06:00
PHST- 2010/10/02 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2011/01/11 06:00 [medline]
AID - radiol.10100732 [pii]
AID - 10.1148/radiol.10100732 [doi]
PST - ppublish
SO  - Radiology. 2010 Dec;257(3):653-61. doi: 10.1148/radiol.10100732. Epub 2010 Sep
      30.


PMID- 20884905
OWN - NLM
STAT- MEDLINE
DCOM- 20110113
LR  - 20191210
IS  - 1527-330X (Electronic)
IS  - 1090-820X (Linking)
VI  - 30
IP  - 5
DP  - 2010 Sep
TI  - The quality of Internet advertising in aesthetic surgery: an in-depth analysis.
PG  - 735-43
LID - 10.1177/1090820X10381987 [doi]
AB  - BACKGROUND: The aesthetic market is a growing business, as evidenced by the
      American Society for Aesthetic Plastic Surgery (ASAPS) reporting an increase of
      147% in the number of cosmetic procedures performed by members since 1997. This
      market is consumer-oriented, relying heavily on advertising for survival amid the
      increasing provider competition. OBJECTIVES: The authors evaluate trends, ethics,
      and efficacy of Internet advertising in aesthetic surgery. METHODS: Medical
      cosmetic providers in Southern California and their Web sites were catalogued
      through sales lists from manufacturers (Medicis and Allergan) and combined with
      advertised providers of surgical treatments. Using the ASAPS/American Society of 
      Aesthetic Plastic Surgeons (ASPS) and American Medical Association Codes of
      Ethics as guidelines, scores were assigned to each Web site and evaluated with
      the provider's board certification. A geographical analysis determined whether
      the presence of high numbers of competitors had an impact on the adherence to
      ethical guidelines for advertising. To examine patient preferences in physician
      advertising, a survey was conducted online. RESULTS: Board-certified plastic
      surgeons showed the highest total ethical scores, followed by otolaryngologists, 
      oromaxillofacial surgeons, and ophthalmologists. No decrement in the quality of
      the advertising was found in densely competitive environments. A consistent
      correlation was found between superior compliance with ethical guidelines and
      board certification in plastic surgery. The patient preference survey of 208
      individuals demonstrated their desire for a well-trained, board-certified plastic
      surgeon to perform their cosmetic procedures. CONCLUSIONS: Although plastic
      surgeons demonstrate greater overall compliance with the ASAPS/ASPS Advertising
      Code of Ethics, they can continue to improve. With the large variety of cosmetic 
      physicians offering the same procedures, maintaining open, honest, and forthright
      communication with the public is essential.
FAU - Wong, Wendy W
AU  - Wong WW
AD  - Department of Plastic Surgery, Loma Linda University Medical Center, Loma Linda, 
      California 92354, USA. wewong@llu.edu
FAU - Camp, Matthew C
AU  - Camp MC
FAU - Camp, Jennifer S
AU  - Camp JS
FAU - Gupta, Subhas C
AU  - Gupta SC
LA  - eng
PT  - Journal Article
PL  - England
TA  - Aesthet Surg J
JT  - Aesthetic surgery journal
JID - 9707469
SB  - IM
CIN - Aesthet Surg J. 2010 Sep;30(5):744. PMID: 20884906
MH  - Adult
MH  - Advertising/ethics/*standards/trends
MH  - Aged
MH  - California
MH  - Certification
MH  - Data Collection
MH  - Ethics, Medical
MH  - Female
MH  - Guideline Adherence
MH  - Guidelines as Topic
MH  - Humans
MH  - Internet/ethics/*standards
MH  - Male
MH  - Middle Aged
MH  - Patient Preference
MH  - Specialty Boards
MH  - Surgery, Plastic/*ethics
MH  - Young Adult
EDAT- 2010/10/05 06:00
MHDA- 2011/01/14 06:00
CRDT- 2010/10/02 06:00
PHST- 2010/10/02 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2011/01/14 06:00 [medline]
AID - 30/5/735 [pii]
AID - 10.1177/1090820X10381987 [doi]
PST - ppublish
SO  - Aesthet Surg J. 2010 Sep;30(5):735-43. doi: 10.1177/1090820X10381987.


PMID- 20884428
OWN - NLM
STAT- MEDLINE
DCOM- 20110215
LR  - 20101004
IS  - 1969-6213 (Electronic)
IS  - 1774-024X (Linking)
VI  - 6
IP  - 4
DP  - 2010 Sep
TI  - ETHICA Award 2010: Antonio Colombo.
PG  - 431
LID - 10.4244/EIJ30V6I4A73 [doi]
LID - EIJ30V6I4A73 [pii]
FAU - Serruys, Patrick W
AU  - Serruys PW
AD  - Thorax Center, Rotterdam, The Netherlands. p.w.j.c.serruys@erasmusmc.nl
FAU - Brugaletta, Salvatore
AU  - Brugaletta S
LA  - eng
PT  - Journal Article
PL  - France
TA  - EuroIntervention
JT  - EuroIntervention : journal of EuroPCR in collaboration with the Working Group on 
      Interventional Cardiology of the European Society of Cardiology
JID - 101251040
SB  - IM
MH  - *Awards and Prizes
MH  - Cardiology
EDAT- 2010/10/05 06:00
MHDA- 2011/02/16 06:00
CRDT- 2010/10/02 06:00
PHST- 2010/10/02 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2011/02/16 06:00 [medline]
AID - EIJ30V6I4A73 [pii]
AID - 10.4244/EIJ30V6I4A73 [doi]
PST - ppublish
SO  - EuroIntervention. 2010 Sep;6(4):431. doi: 10.4244/EIJ30V6I4A73.


PMID- 20884051
OWN - NLM
STAT- MEDLINE
DCOM- 20110407
LR  - 20101122
IS  - 1873-6386 (Electronic)
IS  - 0160-2527 (Linking)
VI  - 33
IP  - 5-6
DP  - 2010 Nov-Dec
TI  - Medical decision-making for incapacitated elders: A "therapeutic interests"
      standard.
PG  - 369-74
LID - 10.1016/j.ijlp.2010.09.008 [doi]
AB  - Some older individuals lack sufficient present cognitive and/or emotional ability
      to make and express autonomous decisions personally. In those situations,
      health-care providers routinely turn to available formal or informal surrogates
      who often must apply the best interests standard in making decisions for the
      incapacitated person. This article contends that defining the best interests
      standard of surrogate decision-making for older adults in terms of optimal or
      ideal choices (truly the patient's "best" interests) frequently sets out an
      unrealizable goal for surrogates to satisfy. Instead, a decision-making standard 
      based on the incapacitated person's "therapeutic" interests is more realistic and
      hence more honest to adopt and apply from legal, ethical, and medical
      perspectives.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Kapp, Marshall B
AU  - Kapp MB
AD  - Center for Innovative Collaboration in Medicine & Law, Florida State University, 
      1115 W Call St, Ste 2350-F, Tallahassee, FL 32306-4300, USA.
      marshall.kapp@med.fsu.edu
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20100929
PL  - Netherlands
TA  - Int J Law Psychiatry
JT  - International journal of law and psychiatry
JID - 7806862
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Beneficence
MH  - *Choice Behavior
MH  - *Decision Making
MH  - *Frail Elderly
MH  - Humans
MH  - Informed Consent/*legislation & jurisprudence/*standards
MH  - Legal Guardians/*legislation & jurisprudence/psychology
MH  - Life Support Care/legislation & jurisprudence/psychology/standards
MH  - Male
MH  - Mental Competency/*legislation & jurisprudence/psychology/*standards
MH  - Palliative Care/legislation & jurisprudence/psychology/standards
MH  - Patient Selection
MH  - Personal Autonomy
MH  - Quality Assurance, Health Care/legislation & jurisprudence/standards
MH  - United States
EDAT- 2010/10/05 06:00
MHDA- 2011/04/08 06:00
CRDT- 2010/10/02 06:00
PHST- 2010/10/02 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2011/04/08 06:00 [medline]
AID - S0160-2527(10)00080-4 [pii]
AID - 10.1016/j.ijlp.2010.09.008 [doi]
PST - ppublish
SO  - Int J Law Psychiatry. 2010 Nov-Dec;33(5-6):369-74. doi:
      10.1016/j.ijlp.2010.09.008. Epub 2010 Sep 29.


PMID- 20883968
OWN - NLM
STAT- MEDLINE
DCOM- 20101019
LR  - 20220129
IS  - 1474-4457 (Electronic)
IS  - 1473-3099 (Linking)
VI  - 10
IP  - 10
DP  - 2010 Oct
TI  - Tuberculosis case-contact research in endemic tropical settings: design, conduct,
      and relevance to other infectious diseases.
PG  - 723-32
LID - 10.1016/S1473-3099(10)70164-X [doi]
AB  - The study of the contacts of patients with tuberculosis has a long history. Where
      tuberculosis is endemic, regular recruitment of tuberculosis cases and their
      household contacts can be done for research and strategic intervention. This
      recruitment provides a platform whereby host, pathogen, and environmental factors
      related to tuberculosis can be investigated and new interventions can be
      assessed. We describe the types of study possible within a tuberculosis
      case-contact study platform and its essential components, including recruitment
      and follow-up of the patients with tuberculosis, their household contacts and
      community controls, assessments and sampling, and data management and processing.
      Sample handling and storage, local engagement, ethical challenges, and the
      strengths and weaknesses of study design are all important issues in case-contact
      research. A case-contact study platform is a powerful research tool to answer
      fundamental questions in tuberculosis and has relevance to the study of other
      major infectious diseases.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Hill, Philip C
AU  - Hill PC
AD  - Centre for International Health, Department of Preventive & Social Medicine,
      University of Otago School of Medicine, Dunedin, New Zealand.
      philip.hill@otago.ac.nz
FAU - Ota, Martin O C
AU  - Ota MO
LA  - eng
GR  - MC_U190071468/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Lancet Infect Dis
JT  - The Lancet. Infectious diseases
JID - 101130150
SB  - IM
MH  - Biomedical Research/ethics/methods
MH  - Contact Tracing/*methods
MH  - *Endemic Diseases
MH  - Family Health
MH  - Humans
MH  - Specimen Handling/methods
MH  - Tuberculosis/*epidemiology/*transmission
EDAT- 2010/10/05 06:00
MHDA- 2010/10/20 06:00
CRDT- 2010/10/02 06:00
PHST- 2010/10/02 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2010/10/20 06:00 [medline]
AID - S1473-3099(10)70164-X [pii]
AID - 10.1016/S1473-3099(10)70164-X [doi]
PST - ppublish
SO  - Lancet Infect Dis. 2010 Oct;10(10):723-32. doi: 10.1016/S1473-3099(10)70164-X.


PMID- 20883714
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20131121
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Linking)
VI  - 35
IP  - 6
DP  - 2011 Aug 1
TI  - The age-dependent effects of selective serotonin reuptake inhibitors in humans
      and rodents: A review.
PG  - 1400-8
LID - 10.1016/j.pnpbp.2010.09.013 [doi]
AB  - The selective serotonin reuptake inhibitor (SSRI) Prozac(R) (fluoxetine) is
      widely prescribed for the treatment of depression and anxiety-related disorders. 
      While extensive research has established that fluoxetine is safe for adults,
      safety is not guaranteed for (unborn) children and adolescents. Some clinical
      studies have reported adverse outcomes, such as premature birth, neonatal
      cardiovascular abnormalities, and pulmonary hypertension in children whose
      mothers used SSRIs during pregnancy. In addition, several reports show that
      adolescent fluoxetine treatment increases risk for suicidal behavior. Despite
      these studies, fluoxetine is not contraindicated in the treatment of depressed
      pregnant women and adolescents. Longitudinal research in humans is limited
      because of ethical reasons and time constraints, and to overcome these
      limitations, rodents are used to increase insight in the age-dependent effects of
      fluoxetine exposure. It has been established that neonatal and adolescent
      fluoxetine exposure leads to paradoxical anxiety- and depression-like features in
      later life of rats and mice, although in some studies adolescent fluoxetine
      exposure was without effects. These age-dependent outcomes of fluoxetine may be
      explained by serotonin's neurotrophic effects, which may vary according to the
      developmental stage of the brain due to epigenetic modifications. Here we review 
      the existing evidence for the age-dependent effects of fluoxetine in humans and
      rodents, address the gaps in our current knowledge and propose directions for
      future research. Given the overlap between human and rodent findings, rodents
      provide heuristic value in further research on the age-dependent effects of
      SSRIs.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Olivier, J D A
AU  - Olivier JD
AD  - Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience,
      Dept. of Cognitive Neuroscience, Radboud University Nijmegen Medical Centre,
      Geert Grooteplein 21, 6525 GA Nijmegen, The Netherlands.
FAU - Blom, T
AU  - Blom T
FAU - Arentsen, T
AU  - Arentsen T
FAU - Homberg, J R
AU  - Homberg JR
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100925
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Serotonin Uptake Inhibitors)
RN  - 01K63SUP8D (Fluoxetine)
RN  - 333DO1RDJY (Serotonin)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Anxiety/chemically induced/*drug therapy
MH  - Behavior, Animal/drug effects/physiology
MH  - Depression/chemically induced/*drug therapy
MH  - Disease Models, Animal
MH  - Fluoxetine/adverse effects/*pharmacology/*therapeutic use
MH  - Humans
MH  - Neuronal Plasticity/drug effects/physiology
MH  - Serotonin/physiology
MH  - Serotonin Uptake Inhibitors/adverse effects/*pharmacology/*therapeutic use
MH  - Synaptic Transmission/drug effects/physiology
EDAT- 2010/10/05 06:00
MHDA- 2011/12/13 00:00
CRDT- 2010/10/02 06:00
PHST- 2010/06/14 00:00 [received]
PHST- 2010/08/07 00:00 [revised]
PHST- 2010/09/15 00:00 [accepted]
PHST- 2010/10/02 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0278-5846(10)00364-7 [pii]
AID - 10.1016/j.pnpbp.2010.09.013 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2011 Aug 1;35(6):1400-8. doi:
      10.1016/j.pnpbp.2010.09.013. Epub 2010 Sep 25.


PMID- 20883143
OWN - NLM
STAT- MEDLINE
DCOM- 20110207
LR  - 20101007
IS  - 1476-4954 (Electronic)
IS  - 1476-4954 (Linking)
VI  - 23 Suppl 3
DP  - 2010 Oct
TI  - Ethical problems in the care of high risk neonates.
PG  - 7-10
LID - 10.3109/14767058.2010.510647 [doi]
AB  - Recent progress in neonatal care has greatly improved the prognosis and the
      probabilities of survival in very sick or very preterm neonates and has modified 
      the concept and limits of the so called viability. However, in some
      circumstances, when the death of the baby can only be postponed temporarily, at
      the price of severe suffering, or when survival is associated with severe
      disabilities and an intolerable life for the child and the family, then it might 
      not be appropriate to utilize all the armamentarium of neonatal intensive care.
      In such circumstances, limitation of intensive treatments (withholding or
      withdrawal) generally invasive and painful, could represent a more human and
      reasonable alternative. The ethical principles underlying those decisions, the
      most frequent situations occurring in practice, the role of parents in the
      decision-making process, and the opinions and behavior of neonatologists from
      many European intensive care units will be examined and discussed.
FAU - Orzalesi, Marcello
AU  - Orzalesi M
AD  - Fondazione Maruzza Lefebvre D'Ovidio Onlus, Via del Nuoto 11, Rome, Italy.
      m.orzalesi@maruzza.org
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Matern Fetal Neonatal Med
JT  - The journal of maternal-fetal & neonatal medicine : the official journal of the
      European Association of Perinatal Medicine, the Federation of Asia and Oceania
      Perinatal Societies, the International Society of Perinatal Obstetricians
JID - 101136916
SB  - IM
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Newborn, Diseases/*therapy
MH  - Infant, Premature/physiology
MH  - Intensive Care, Neonatal/*ethics/methods
MH  - Neonatology/*ethics/methods
MH  - Parental Consent/ethics
MH  - Professional-Family Relations/ethics
MH  - Risk
EDAT- 2010/10/05 06:00
MHDA- 2011/02/08 06:00
CRDT- 2010/10/02 06:00
PHST- 2010/10/02 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2011/02/08 06:00 [medline]
AID - 10.3109/14767058.2010.510647 [doi]
PST - ppublish
SO  - J Matern Fetal Neonatal Med. 2010 Oct;23 Suppl 3:7-10. doi:
      10.3109/14767058.2010.510647.


PMID- 20882800
OWN - NLM
STAT- MEDLINE
DCOM- 20101102
LR  - 20161125
IS  - 1354-5752 (Print)
IS  - 1354-5752 (Linking)
VI  - 18
IP  - 5
DP  - 2010 Sep
TI  - Family-witnessed resuscitation.
PG  - 10-4
AB  - Family-witnessed resuscitation is a controversial subject for healthcare
      professionals and support for the practice is not universal (Albarran and
      Stafford 1999, Kissoon 2006). Research suggests, however, that the advantages of 
      this form of resuscitation for relatives far outweigh the disadvantages, and that
      hospital staff can support the practice without hindering the clinical care of
      patients. This article explores the ethical issues raised, as well as the views
      of patients, families and staff on the subject, and suggests that there should be
      guidelines on the practice in all emergency departments where it is likely to
      take place.
FAU - Boucher, Melanie
AU  - Boucher M
AD  - Emergency Department, Plymouth Hospital NHS Trust.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Emerg Nurse
JT  - Emergency nurse : the journal of the RCN Accident and Emergency Nursing
      Association
JID - 9208913
MH  - *Decision Making
MH  - *Family
MH  - Humans
MH  - Practice Guidelines as Topic
MH  - Professional-Family Relations
MH  - *Resuscitation
MH  - United Kingdom
MH  - *Visitors to Patients
EDAT- 2010/10/05 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/10/02 06:00
PHST- 2010/10/02 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - 10.7748/en2010.09.18.5.10.c7970 [doi]
PST - ppublish
SO  - Emerg Nurse. 2010 Sep;18(5):10-4. doi: 10.7748/en2010.09.18.5.10.c7970.


PMID- 20882749
OWN - NLM
STAT- MEDLINE
DCOM- 20101029
LR  - 20161125
IS  - 0037-9247 (Print)
IS  - 0037-9247 (Linking)
IP  - 2
DP  - 2010
TI  - [Safety of the patient and the Mammography Program in the Grand Duchy of
      Luxembourg: Care of cancers detected by mammography. Retrospective studies].
PG  - 303-13
AB  - UNLABELLED: In Luxemburg, the national breast cancer mammography screening
      programme has been running for 18 years. The Coordinating Centre treats
      approximately 17,000 files a year. The Health Directorate, as promoter of the
      "Programme Mammographie", is obliged to provide itself with a maximum of
      guarantees; within the framework of its legal missions, it has to implement all
      the possible means in order that the whole approach assures minimal adverse
      effects. The technical quality of the 9 centres is at the level required by the
      European Guidelines for Quality Assurance in Mammography Screening and Diagnosis,
      4th edition. The quality of the readings was already the subject of 2 evaluations
      of the performance of the readers: the mean accuracy of the first readers to
      detect cancers is 87%, of the second readers 97%. The mean recall rate for
      assessment is about 6%. The double reading assures the detection of between 15
      and 21% additional cancers, depending on the years. The imaging of diagnostic
      assessment has been the subject of a retrospective study. Out of 392 cancers,
      time from assessment to diagnosis was longer then 24 months for 17 women (4%).
      Examples are described and reasons for negative assessment are listed. The main
      cause is the multiplicity of the doctors acting in the assessment process,
      resulting in a default of the examination synthesis and a certain lack of
      communication and multidisciplinary approach. More convergence in diagnostic
      breast assessment and a shortening of delays between screening and diagnosis, are
      desirable. IN CONCLUSION: The evolution towards Specialist Centres for breast
      cancer care answers an ethical obligation which the initiators of a public health
      programme have to assume, such as the organization of a high quality breast
      cancer screening programme.
FAU - Wagnon, Marie-Christine
AU  - Wagnon MC
AD  - Ministere de la Sante, Allee Marconi, L-2120 Luxembourg.
      marie-christine.wagnon@ms.etat.lu
FAU - Scharpantgen, Astrid
AU  - Scharpantgen A
FAU - Back, Carlo
AU  - Back C
FAU - Hansen-Koenig, Danielle
AU  - Hansen-Koenig D
LA  - fre
PT  - Journal Article
TT  - La Securitre du Patient et le Programme Mammographie du Grand-Duche de
      Luxembourg: Prise en charge des cancers detectes par la mammographie. Etudes
      retrospectives.
PL  - Luxembourg
TA  - Bull Soc Sci Med Grand Duche Luxemb
JT  - Bulletin de la Societe des sciences medicales du Grand-Duche de Luxembourg
JID - 7503402
SB  - IM
MH  - Breast Neoplasms/*diagnostic imaging/surgery/therapy
MH  - Female
MH  - Humans
MH  - Mammography/*standards
MH  - Mass Screening/methods
MH  - Retrospective Studies
MH  - *Safety
EDAT- 2010/10/05 06:00
MHDA- 2010/10/30 06:00
CRDT- 2010/10/02 06:00
PHST- 2010/10/02 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2010/10/30 06:00 [medline]
PST - ppublish
SO  - Bull Soc Sci Med Grand Duche Luxemb. 2010;(2):303-13.


PMID- 20862620
OWN - NLM
STAT- MEDLINE
DCOM- 20101014
LR  - 20100923
IS  - 1439-4413 (Electronic)
IS  - 0012-0472 (Linking)
VI  - 135 Suppl 3
DP  - 2010 Oct
TI  - [Pulmonary hypertension due to chronic lung disease. Recommendations of the
      Cologne Consensus Conference 2010].
PG  - S115-24
LID - 10.1055/s-0030-1263318 [doi]
AB  - The 2009 European Guidelines on Pulmonary Hypertension did not cover only
      pulmonary arterial hypertension (PAH) but also some aspects of pulmonary
      hypertension (PH) in chronic lung disease. The European Guidelines point out that
      the drugs currently used to treat patients with PAH (prostanoids, endothelin
      receptor antagonists and phosphodiesterase-5 inhibitors) have not been
      sufficiently investigated in other forms of PH. Therefore, the European
      Guidelines do not recommend the use of these drugs in patients with chronic lung 
      disease and PH. This recommendation, however, is not always in agreement with
      medical ethics as physicians feel sometimes inclined to treat other form of
      pulmonary hypertension which may affect quality of life and survival of these
      patients in a similar manner. In June 2010, a group of German experts met in
      Cologne, Germany, to discuss open and controversial issues surrounding the
      practical implementation of the European Guidelines. The conference was sponsored
      by the German Society of Cardiology, the German Society of Respiratory Medicine
      and the German Society of Pediatric Cardiology. One of the working groups was
      dedicated to the diagnosis and treatment of PH in patients with chronic lung
      disease. The recommendations of this working group are summarized in the present 
      paper.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Hoeper, M M
AU  - Hoeper MM
AD  - Klinik fur Pneumologie, Medizinische Hochschule Hannover, Hannover.
      hoeper.marius@mh-hannover.de
FAU - Andreas, S
AU  - Andreas S
FAU - Bastian, A
AU  - Bastian A
FAU - Claussen, M
AU  - Claussen M
FAU - Ghofrani, H A
AU  - Ghofrani HA
FAU - Gorenflo, M
AU  - Gorenflo M
FAU - Grohe, C
AU  - Grohe C
FAU - Gunther, A
AU  - Gunther A
FAU - Halank, M
AU  - Halank M
FAU - Hammerl, P
AU  - Hammerl P
FAU - Held, M
AU  - Held M
FAU - Kruger, S
AU  - Kruger S
FAU - Lange, T J
AU  - Lange TJ
FAU - Reichenberger, F
AU  - Reichenberger F
FAU - Sablotzki, A
AU  - Sablotzki A
FAU - Staehler, G
AU  - Staehler G
FAU - Stark, W
AU  - Stark W
FAU - Wirtz, H
AU  - Wirtz H
FAU - Witt, C
AU  - Witt C
FAU - Behr, J
AU  - Behr J
CN  - German Society of Cardiology (DGK), the German Society of Respiratory Medicine
      (DGP) and the German Society of Pediatric Cardiology (DGPK)
LA  - ger
PT  - Consensus Development Conference
PT  - English Abstract
PT  - Journal Article
PT  - Practice Guideline
TT  - Pulmonale Hypertonie bei chronischen Lungenerkrankungen: Empfehlungen der Kolner 
      Konsensus-Konferenz 2010.
DEP - 20100922
PL  - Germany
TA  - Dtsch Med Wochenschr
JT  - Deutsche medizinische Wochenschrift (1946)
JID - 0006723
RN  - 0 (Vasodilator Agents)
SB  - IM
MH  - Chronic Disease
MH  - Ethics, Medical
MH  - *Evidence-Based Medicine/ethics
MH  - Germany
MH  - Humans
MH  - Hypertension, Pulmonary/diagnosis/*etiology/mortality/therapy
MH  - Lung Diseases/*complications/diagnosis/mortality/therapy
MH  - Quality of Life
MH  - Vasodilator Agents/adverse effects/therapeutic use
EDAT- 2010/10/05 06:00
MHDA- 2010/10/15 06:00
CRDT- 2010/09/24 06:00
PHST- 2010/09/24 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2010/10/15 06:00 [medline]
AID - 10.1055/s-0030-1263318 [doi]
PST - ppublish
SO  - Dtsch Med Wochenschr. 2010 Oct;135 Suppl 3:S115-24. doi: 10.1055/s-0030-1263318. 
      Epub 2010 Sep 22.


PMID- 20882173
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20220318
IS  - 0976-2817 (Electronic)
IS  - 0019-5049 (Linking)
VI  - 54
IP  - 4
DP  - 2010 Jul
TI  - We should care more about intracuff pressure: The actual situation in government 
      sector teaching hospital.
PG  - 314-7
LID - 10.4103/0019-5049.68374 [doi]
AB  - Endotracheal tube (ETT) should have intracuff pressure (ICP) in the range of 20
      to 30 cm water (H(2)O). In this observational study, we studied the trend amongst
      anaesthesiologist in choosing the type of ETT and their ability to assess optimum
      ICP clinically. After institutional ethics committee approval, we observed 75
      patients under general endotracheal anaesthesia in Government Medical College.
      Anaesthesiologists were blinded to study purpose. The type of ETT used and
      magnitude of ICP was recorded. ICP was measured using simple aneroid manometer.
      Once the pressure was measured, it was readjusted to normal range and nitrous
      oxide was allowed to start. Red rubber tube was used in 18.7% and polyvinyl
      chloride (PVC) in 81.3% cases. The anaesthesiologists were not able to assess ICP
      in the recommended range clinically in 100% cases when red rubber ETT was used
      and in 40% cases when portex ETT was used. Red rubber ETT (reusable) with
      low-volume high-pressure cuff is still in use, though the trend is shifting
      towards more of using PVC ETT. Anaesthesiologists were not able to inflate the
      ETT cuff to the recommended range in spite of their clinical expertise (more than
      5 years of teaching experience) in significant number of cases. We recommend the 
      use of simple aneroid manometer for objective monitoring of ICP over subjective
      assessment, not only in red rubber, but also in PVC ETT.
FAU - Trivedi, Lopa
AU  - Trivedi L
AD  - Department of Anaesthesiology, Government Medical College and Sir T. Hospital,
      Bhavnagar, Gujarat, India.
FAU - Jha, Pramila
AU  - Jha P
FAU - Bajiya, Narasi Ram
AU  - Bajiya NR
FAU - Tripathi, Dc
AU  - Tripathi D
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Anaesth
JT  - Indian journal of anaesthesia
JID - 0013243
PMC - PMC2943700
OTO - NOTNLM
OT  - Aneroid manometer
OT  - intra cuff pressure
OT  - polyvinyl chloride endotracheal tube
OT  - red rubber endotracheal tube
EDAT- 2010/10/01 06:00
MHDA- 2010/10/01 06:01
CRDT- 2010/10/01 06:00
PHST- 2010/10/01 06:00 [entrez]
PHST- 2010/10/01 06:00 [pubmed]
PHST- 2010/10/01 06:01 [medline]
AID - 10.4103/0019-5049.68374 [doi]
PST - ppublish
SO  - Indian J Anaesth. 2010 Jul;54(4):314-7. doi: 10.4103/0019-5049.68374.


PMID- 20882085
OWN - NLM
STAT- MEDLINE
DCOM- 20101012
LR  - 20181201
IS  - 0807-7096 (Electronic)
IS  - 0029-2001 (Linking)
VI  - 130
IP  - 18
DP  - 2010 Sep 23
TI  - [The problem of evil in families--the filmmaker Michael Haneke].
PG  - 1837-40
LID - 10.4045/tidsskr.10.0191 [doi]
AB  - With the beautiful and dark film "The white ribbon", from 2009, the Austrian film
      director Michael Haneke consolidated his status as an international success. A
      central theme in his films is evilness and its roots. But just as important is
      his ambition to develop films where evil is not only portrayed, but where
      spectators are challenged to relate to their own ethical standards and their role
      as spectators. Haneke is a highly original filmmaker with his consistent search
      for a film aesthetic that stimulates ethical self-reflection and mentalizing. He 
      partly succeeds in this quest.
FAU - Skarderud, Finn
AU  - Skarderud F
AD  - Avdeling for helse- og sosialfag, Hogskolen i Lillehammer, 2626 Lillehammer,
      Norway. finns@online.no
LA  - nor
PT  - Biography
PT  - Historical Article
PT  - Journal Article
PT  - Portrait
TT  - Det ondes familieproblem--filmskaperen Michael Haneke.
PL  - Norway
TA  - Tidsskr Nor Laegeforen
JT  - Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny
      raekke
JID - 0413423
SB  - IM
MH  - Austria
MH  - Ethics
MH  - Family/*psychology
MH  - Family Conflict/*psychology
MH  - Germany
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Morals
MH  - *Motion Pictures
PS  - Haneke M
FPS - Haneke, Michael
EDAT- 2010/10/01 06:00
MHDA- 2010/10/13 06:00
CRDT- 2010/10/01 06:00
PHST- 2010/10/01 06:00 [entrez]
PHST- 2010/10/01 06:00 [pubmed]
PHST- 2010/10/13 06:00 [medline]
AID - 2016805 [pii]
AID - 10.4045/tidsskr.10.0191 [doi]
PST - ppublish
SO  - Tidsskr Nor Laegeforen. 2010 Sep 23;130(18):1837-40. doi:
      10.4045/tidsskr.10.0191.


PMID- 20881487
OWN - NLM
STAT- MEDLINE
DCOM- 20110906
LR  - 20220129
IS  - 1473-6551 (Electronic)
IS  - 1350-7540 (Linking)
VI  - 23
IP  - 6
DP  - 2010 Dec
TI  - Decoding the neural correlates of consciousness.
PG  - 649-55
LID - 10.1097/WCO.0b013e32834028c7 [doi]
AB  - PURPOSE OF REVIEW: Multivariate pattern analysis (MVPA) is an emerging technique 
      for analysing functional imaging data that is capable of a much closer
      approximation of neuronal activity than conventional methods. This review will
      outline the advantages, applications and limitations of MVPA in understanding the
      neural correlates of consciousness. RECENT FINDINGS: MVPA has provided important 
      insights into the processing of perceptual information by revealing
      content-specific information at early stages of perceptual processing. It has
      also shed light on the processing of memories and decisions. In combination with 
      techniques to reconstruct viewed images, MVPA can also be used to reveal the
      contents of consciousness. SUMMARY: The development of multivariate pattern
      analysis techniques allows content-specific and detailed information to be
      extracted from functional MRI data. This may lead to new therapeutic applications
      but also raises important ethical considerations.
FAU - Weil, Rimona S
AU  - Weil RS
AD  - Wellcome Trust Centre for Neuroimaging at UCL, Institute of Neurology, University
      College London, London, UK. r.weil@fil.ion.ucl.ac.uk
FAU - Rees, Geraint
AU  - Rees G
LA  - eng
GR  - 082334/WT_/Wellcome Trust/United Kingdom
GR  - G0500743/MRC_/Medical Research Council/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Curr Opin Neurol
JT  - Current opinion in neurology
JID - 9319162
SB  - IM
MH  - Consciousness/*classification/*physiology
MH  - Humans
MH  - Image Processing, Computer-Assisted/*methods/trends
MH  - Magnetic Resonance Imaging/*methods/trends
MH  - Neurons/*classification/*physiology
MH  - Pattern Recognition, Automated/*methods/trends
EDAT- 2010/10/01 06:00
MHDA- 2011/09/07 06:00
CRDT- 2010/10/01 06:00
PHST- 2010/10/01 06:00 [entrez]
PHST- 2010/10/01 06:00 [pubmed]
PHST- 2011/09/07 06:00 [medline]
AID - 10.1097/WCO.0b013e32834028c7 [doi]
PST - ppublish
SO  - Curr Opin Neurol. 2010 Dec;23(6):649-55. doi: 10.1097/WCO.0b013e32834028c7.


PMID- 20881450
OWN - NLM
STAT- MEDLINE
DCOM- 20110119
LR  - 20191027
IS  - 1880-1293 (Electronic)
IS  - 0022-9717 (Linking)
VI  - 59
IP  - 3
DP  - 2010
TI  - Getting started in medical education scholarship.
PG  - 96-103
AB  - Education scholarship and research are critically important in extending our
      ability to teach and assess effectively. Those considering a scholarly project in
      medical education should consider the following tips, learned from personal
      experience and supported by literature: 1) get some training, 2) find a mentor,
      3) ask important questions, 4) start small and grow, 5) aim high, 6) don't wait
      for the perfect study, 7) plan for adequate time and other resources, 8) attend
      to ethical issues, 9) network with others in the field, and 10) recognize that
      this is hard work. By following these steps and planning ahead, scholars will be 
      better poised to make meaningful contributions to the art and science of medical 
      education.
FAU - Cook, David A
AU  - Cook DA
AD  - Division of General Internal Medicine and Office of Education Research, Mayo
      Clinic College of Medicine, Rochester, MN 55905, USA. cook.david33@mayo.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Keio J Med
JT  - The Keio journal of medicine
JID - 0376354
SB  - IM
MH  - Education, Medical/*methods/*standards
MH  - Humans
MH  - *Mentors
MH  - Research Design/*standards
EDAT- 2010/10/01 06:00
MHDA- 2011/01/20 06:00
CRDT- 2010/10/01 06:00
PHST- 2010/10/01 06:00 [entrez]
PHST- 2010/10/01 06:00 [pubmed]
PHST- 2011/01/20 06:00 [medline]
AID - 10.2302/kjm.59.96 [doi]
PST - ppublish
SO  - Keio J Med. 2010;59(3):96-103. doi: 10.2302/kjm.59.96.


PMID- 20880895
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20100930
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 10
DP  - 2010 Oct
TI  - How to teach moral theories in applied ethics.
PG  - 635-8
LID - 10.1136/jme.2009.032052 [doi]
AB  - Recent discussion has focused on whether or not to teach moral theories, and, if 
      yes, to what extent. In this piece the author argues that the criticisms of
      teaching moral theories raised by Rob Lawlor should lead us to reconsider not
      whether but how to teach moral theories. It seems that most of the problems
      Lawlor identifies derive from an uncritical, theory-led approach to teaching. It 
      is suggested that we might instead start by discussing practical cases or the
      desiderata of a successful moral theory, and then build up to comparing theories 
      such as consequentialism, deontology, and so on. In this way, theories are taught
      but students do not take them to be the alpha and omega of moral thinking.
FAU - Saunders, Ben
AU  - Saunders B
AD  - University of Stirling, Stirling FK9 4LA, UK. b.m.saunders@stir.ac.uk
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Ethical Theory
MH  - Ethics, Medical/*education
MH  - Humans
MH  - *Morals
MH  - Teaching/*methods
EDAT- 2010/10/01 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/10/01 06:00
PHST- 2010/10/01 06:00 [entrez]
PHST- 2010/10/01 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - 36/10/635 [pii]
AID - 10.1136/jme.2009.032052 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Oct;36(10):635-8. doi: 10.1136/jme.2009.032052.


PMID- 20880805
OWN - NLM
STAT- MEDLINE
DCOM- 20101109
LR  - 20100930
IS  - 0030-6002 (Print)
IS  - 0030-6002 (Linking)
VI  - 151
IP  - 41
DP  - 2010 Oct 10
TI  - [Are the flight security measures good for the patients? The "sickurity"
      problem].
PG  - 1702-7
LID - 10.1556/OH.2010.28973 [doi]
AB  - Due to the stiffening requirements of security measures at the airports,
      prevention of air-travel related illnesses have become more difficult. The
      backlash effects of restrictions (e.g. fluid and movement restrictions) can
      trigger or even improve pathophysiological processes. The most advanced security 
      check methods, the full body scan, besides ethical and moral considerations, may 
      induce yet unknown pathological processes. We face the similar problem with the
      traveller, who becomes ill or injured during the trip. In this case, repatriation
      is often required, which is usually accomplished by commercial airlines. If
      patient should be transported by stretcher, it is also available on regular
      flight, but in this case he/she must be accompanied by a medical professional.
      This solution raises much more security problem: not only the sick person and the
      medical team, but even their medical equipments and medicines have to be checked.
      Due to the lack of standardised regulations the security staff solves the problem
      by various attempts from emphatic approach till refusal. For these reasons, a
      clear and exact regulation is needed, which must be based upon medical experts'
      opinion, and should deal not only with the flight security but with the patient's
      security, as well. This regulation can cease the patients and their medical
      accompanied persons' to be defencelessness against local authorities and security
      services. The same is true for handicapped persons. Author suggests solutions for
      the problem, balancing between flight security and the patient's "sickurity".
FAU - Felkai, Peter
AU  - Felkai P
AD  - SOS Hungary Orvosi Szolgalat, Budapest. peter.felkai@soshungary.hu
LA  - hun
PT  - English Abstract
PT  - Journal Article
TT  - Repuloteri biztonsag kontra betegbiztonsag? A "sickurity" problemaja.
PL  - Hungary
TA  - Orv Hetil
JT  - Orvosi hetilap
JID - 0376412
SB  - IM
MH  - *Aerospace Medicine
MH  - Aircraft
MH  - Humans
MH  - Security Measures/trends
MH  - *Transportation of Patients/standards
MH  - *Travel/psychology
EDAT- 2010/10/01 06:00
MHDA- 2010/11/10 06:00
CRDT- 2010/10/01 06:00
PHST- 2010/10/01 06:00 [entrez]
PHST- 2010/10/01 06:00 [pubmed]
PHST- 2010/11/10 06:00 [medline]
AID - E275X3317539910R [pii]
AID - 10.1556/OH.2010.28973 [doi]
PST - ppublish
SO  - Orv Hetil. 2010 Oct 10;151(41):1702-7. doi: 10.1556/OH.2010.28973.


PMID- 20880251
OWN - NLM
STAT- MEDLINE
DCOM- 20110211
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 38
IP  - 3
DP  - 2010 Fall
TI  - Currents in contemporary ethics. State run newborn screening in the genomic era, 
      or how to avoid drowning when drinking from a fire hose.
PG  - 697-700
LID - 10.1111/j.1748-720X.2010.00522.x [doi]
FAU - Clayton, Ellen Wright
AU  - Clayton EW
AD  - Center for Biomedical Ethics and Society, Vanderbilt University.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - *Genetic Privacy
MH  - Genetic Testing/ethics/legislation & jurisprudence/*trends
MH  - *Health Policy
MH  - Humans
MH  - Infant, Newborn
MH  - Mandatory Testing/ethics/legislation & jurisprudence/*trends
MH  - Neonatal Screening/ethics/legislation & jurisprudence/*trends
MH  - United States
EDAT- 2010/10/01 06:00
MHDA- 2011/02/12 06:00
CRDT- 2010/10/01 06:00
PHST- 2010/10/01 06:00 [entrez]
PHST- 2010/10/01 06:00 [pubmed]
PHST- 2011/02/12 06:00 [medline]
AID - 10.1111/j.1748-720X.2010.00522.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2010 Fall;38(3):697-700. doi: 10.1111/j.1748-720X.2010.00522.x.


PMID- 20880151
OWN - NLM
STAT- MEDLINE
DCOM- 20110217
LR  - 20131121
IS  - 1460-9592 (Electronic)
IS  - 1155-5645 (Linking)
VI  - 20
IP  - 11
DP  - 2010 Nov
TI  - Slower administration of propofol preserves adequate respiration in children.
PG  - 1001-8
LID - 10.1111/j.1460-9592.2010.03398.x [doi]
AB  - BACKGROUND: Propofol is a versatile anesthetic agent used in pediatric practice
      to facilitate investigational and interventional procedures. Propofol can cause
      significant respiratory depression, the management of which may require advanced 
      airway management skills. This investigation aimed to increase the safety of
      propofol administration by developing a dosing schedule that would preserve
      spontaneous respiration in at least 95% of subjects. METHODS: With Research
      Ethics Board approval and informed consent, American Society of
      Anesthesiologists' Status I and II children aged 6-15 years presenting for upper 
      or lower gastrointestinal endoscopy were enrolled. An intravenous loading dose of
      propofol (4 mg.kg(-1) ) was administered at a rate determined by a randomization 
      schedule in a two-phased study. Following the loading dose, additional propofol
      was infused at 200 mcg.kg(-1) .min(-1) for 5 min or until respiratory
      insufficiency was observed. In Phase I, the infusion rate was modified by 100
      mcg.kg(-1) .min(-1) increments depending upon the respiratory response of the
      previous subject. In Phase II, the duration of infusion was randomized according 
      to a Biased Coin Design principle to determine the 95% threshold for respiratory 
      insufficiency. RESULTS: Fifty subjects were included in the analysis. Infusion
      rates ranged from 1000 to 2300 mcg.kg(-1) .min(-1) . Seven subjects experienced
      respiratory insufficiency. The mean (sd) time to respiratory insufficiency was
      104 (36) s and duration was 93 (51) s. A propofol loading dose administered over 
      3.0 min (CI = 1.9-3.4 min) maintained spontaneous respiration in 95% of subjects.
      CONCLUSIONS: The respiratory response to propofol is highly variable in children.
      Slower infusion of propofol will result in a lower risk of respiratory
      depression.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Dosani, Maryam
AU  - Dosani M
AD  - Department of Anesthesiology, Pharmacology and Therapeutics, The University of
      British Columbia, Vancouver, BC, Canada.
FAU - McCormack, Jon
AU  - McCormack J
FAU - Reimer, Eleanor
AU  - Reimer E
FAU - Brant, Rollin
AU  - Brant R
FAU - Dumont, Guy
AU  - Dumont G
FAU - Lim, Joanne
AU  - Lim J
FAU - Mark Ansermino, J
AU  - Mark Ansermino J
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20100929
PL  - France
TA  - Paediatr Anaesth
JT  - Paediatric anaesthesia
JID - 9206575
RN  - 0 (Anesthetics, Intravenous)
RN  - 142M471B3J (Carbon Dioxide)
RN  - YI7VU623SF (Propofol)
SB  - IM
MH  - Adolescent
MH  - *Anesthesia, Intravenous
MH  - Anesthetics, Intravenous/*administration & dosage
MH  - Blood Pressure/drug effects
MH  - Carbon Dioxide/blood
MH  - Child
MH  - Digestive System Surgical Procedures
MH  - Double-Blind Method
MH  - Electroencephalography/drug effects
MH  - Entropy
MH  - Female
MH  - Humans
MH  - Male
MH  - Monitoring, Intraoperative
MH  - Propofol/*administration & dosage
MH  - Respiratory Function Tests
MH  - Respiratory Insufficiency/physiopathology
MH  - Respiratory Mechanics/*drug effects
MH  - Sample Size
MH  - Tidal Volume/drug effects
MH  - Treatment Outcome
EDAT- 2010/10/01 06:00
MHDA- 2011/02/18 06:00
CRDT- 2010/10/01 06:00
PHST- 2010/10/01 06:00 [entrez]
PHST- 2010/10/01 06:00 [pubmed]
PHST- 2011/02/18 06:00 [medline]
AID - 10.1111/j.1460-9592.2010.03398.x [doi]
PST - ppublish
SO  - Paediatr Anaesth. 2010 Nov;20(11):1001-8. doi: 10.1111/j.1460-9592.2010.03398.x. 
      Epub 2010 Sep 29.


PMID- 20879888
OWN - NLM
STAT- MEDLINE
DCOM- 20101007
LR  - 20100930
IS  - 1533-4406 (Electronic)
IS  - 0028-4793 (Linking)
VI  - 363
IP  - 14
DP  - 2010 Sep 30
TI  - The ethics of placebo in studies with fracture end points in osteoporosis.
PG  - 1367-70; discussion e21
LID - 10.1056/NEJMsb1006120 [doi]
FAU - Stein, C Michael
AU  - Stein CM
AD  - Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University 
      School of Medicine, Nashville, USA.
FAU - Ray, Wayne A
AU  - Ray WA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - N Engl J Med
JT  - The New England journal of medicine
JID - 0255562
RN  - 0 (Bone Density Conservation Agents)
RN  - 0 (Placebos)
SB  - IM
MH  - Bone Density Conservation Agents/therapeutic use
MH  - Female
MH  - Fractures, Bone/*prevention & control
MH  - Humans
MH  - Osteoporosis, Postmenopausal/complications/*drug therapy
MH  - Placebos/*therapeutic use
MH  - Randomized Controlled Trials as Topic/*ethics/methods
EDAT- 2010/10/01 06:00
MHDA- 2010/10/12 06:00
CRDT- 2010/10/01 06:00
PHST- 2010/10/01 06:00 [entrez]
PHST- 2010/10/01 06:00 [pubmed]
PHST- 2010/10/12 06:00 [medline]
AID - 10.1056/NEJMsb1006120 [doi]
PST - ppublish
SO  - N Engl J Med. 2010 Sep 30;363(14):1367-70; discussion e21. doi:
      10.1056/NEJMsb1006120.


PMID- 20879664
OWN - NLM
STAT- MEDLINE
DCOM- 20101102
LR  - 20161125
IS  - 1462-2815 (Print)
IS  - 1462-2815 (Linking)
VI  - 83
IP  - 9
DP  - 2010 Sep
TI  - Protection of vulnerable adults: an interdisciplinary workshop.
PG  - 29-32
AB  - This paper reports on the development, delivery, content and student evaluation
      of a comprehensive elder abuse and self-neglect workshop for public health
      nursing and social work students.The workshop provided an interdisciplinary
      shared learning experience for the students to prepare them for their critical
      role in safeguarding vulnerable adults. The aim of the workshop was to increase
      knowledge, awareness and understanding of roles and responsibilities and critical
      practice problems in the prevention and management of elder abuse and
      self-neglect. The shared learning approach provided clarity on roles and
      responsibility, valuing and respecting the contribution of each team member. The 
      importance of building communication and trust with team members and clients was 
      seen as critical. Through case studies and group discussion, assessment and
      practice skills were developed and awareness heightened on the complexity of the 
      critical practice problems and ethical issues.
FAU - Day, Mary Rose
AU  - Day MR
AD  - University College Cork, Ireland.
FAU - Bantry-White, Eleanor
AU  - Bantry-White E
FAU - Glavin, Pauline
AU  - Glavin P
LA  - eng
PT  - Journal Article
PL  - England
TA  - Community Pract
JT  - Community practitioner : the journal of the Community Practitioners' & Health
      Visitors' Association
JID - 9809060
MH  - Aged
MH  - Aged, 80 and over
MH  - Curriculum
MH  - Elder Abuse/*prevention & control
MH  - Female
MH  - Humans
MH  - Ireland
MH  - Program Evaluation
MH  - Public Health Nursing/*education
MH  - *Self Care
MH  - Social Work/*education
MH  - United Kingdom
MH  - *Vulnerable Populations
EDAT- 2010/10/01 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/10/01 06:00
PHST- 2010/10/01 06:00 [entrez]
PHST- 2010/10/01 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
PST - ppublish
SO  - Community Pract. 2010 Sep;83(9):29-32.


PMID- 20879651
OWN - NLM
STAT- MEDLINE
DCOM- 20101012
LR  - 20220408
IS  - 1029-4864 (Print)
IS  - 1029-4864 (Linking)
VI  - 65
IP  - 6
DP  - 2010 Jul
TI  - Dental ethics case. 3: Informed consent: risks and benefits of treatment.
PG  - 270-1
FAU - Naidoo, S
AU  - Naidoo S
AD  - Department of Community Oral Health, University of the Western Cape, Private Bag 
      XI, Tygerberg. suenaidoo@uwc.ac.za
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - SADJ
JT  - SADJ : journal of the South African Dental Association = tydskrif van die
      Suid-Afrikaanse Tandheelkundige Vereniging
JID - 9812497
MH  - Duty to Warn/ethics
MH  - *Ethics, Dental
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Molar, Third/surgery
MH  - Risk Assessment/*ethics
MH  - Tooth Extraction/adverse effects/ethics
EDAT- 2010/10/01 06:00
MHDA- 2010/10/13 06:00
CRDT- 2010/10/01 06:00
PHST- 2010/10/01 06:00 [entrez]
PHST- 2010/10/01 06:00 [pubmed]
PHST- 2010/10/13 06:00 [medline]
PST - ppublish
SO  - SADJ. 2010 Jul;65(6):270-1.


PMID- 20879626
OWN - NLM
STAT- MEDLINE
DCOM- 20101025
LR  - 20181201
IS  - 0094-6354 (Print)
IS  - 0094-6354 (Linking)
VI  - 78
IP  - 4
DP  - 2010 Aug
TI  - Patient privacy and social media.
PG  - 270-4
AB  - Healthcare providers using social media must remain mindful of professional
      boundaries and patients' privacy rights. Facebook and other online postings must 
      comply with the Health Insurance Portability and Accountability Act of 1996
      (HIPAA), applicable facility policy, state law, and AANA's Code of Ethics.
FAU - Hader, Amy L
AU  - Hader AL
AD  - American Association of Nurse Anesthetists, Park Ridge, Illinois, USA.
FAU - Brown, Evan D
AU  - Brown ED
LA  - eng
PT  - Journal Article
PT  - Legal Case
PL  - United States
TA  - AANA J
JT  - AANA journal
JID - 0431420
MH  - Blogging/ethics/*legislation & jurisprudence
MH  - Communications Media/ethics/*legislation & jurisprudence
MH  - Confidentiality/ethics/*legislation & jurisprudence
MH  - Humans
MH  - Internet/ethics/*legislation & jurisprudence
MH  - Nurse Anesthetists/ethics/*legislation & jurisprudence
MH  - United States
EDAT- 2010/10/01 06:00
MHDA- 2010/10/26 06:00
CRDT- 2010/10/01 06:00
PHST- 2010/10/01 06:00 [entrez]
PHST- 2010/10/01 06:00 [pubmed]
PHST- 2010/10/26 06:00 [medline]
PST - ppublish
SO  - AANA J. 2010 Aug;78(4):270-4.


PMID- 20879613
OWN - NLM
STAT- MEDLINE
DCOM- 20101102
LR  - 20100930
IS  - 8756-8160 (Print)
IS  - 8756-8160 (Linking)
VI  - 26
IP  - 1
DP  - 2010 Summer
TI  - Other people's lives: reflections on medicine, ethics, and euthanasia.
PG  - 33-76
FAU - Fenigsen, Richard
AU  - Fenigsen R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Issues Law Med
JT  - Issues in law & medicine
JID - 8511295
SB  - IM
MH  - *Clinical Medicine
MH  - Euthanasia/ethics
MH  - Humans
MH  - *Philosophy, Medical
MH  - Physician's Role
EDAT- 2010/10/01 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/10/01 06:00
PHST- 2010/10/01 06:00 [entrez]
PHST- 2010/10/01 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
PST - ppublish
SO  - Issues Law Med. 2010 Summer;26(1):33-76.


PMID- 20879608
OWN - NLM
STAT- MEDLINE
DCOM- 20101115
LR  - 20170214
IS  - 0094-2405 (Print)
IS  - 0094-2405 (Linking)
VI  - 37
IP  - 8
DP  - 2010 Aug
TI  - Recommended ethics curriculum for medical physics graduate and residency
      programs: report of Task Group 159.
PG  - 4495-500
AB  - The AAPM Professional Council approved the formation of a task group in 2007,
      whose purpose is to develop recommendations for an ethics curriculum for medical 
      physics graduate and residency programs. Existing program's ethics curricula
      range in scope and content considerably. It is desirable to have a more uniform
      baseline curriculum for all programs. Recommended subjects areas, suggested
      ethics references, and a sample curriculum are included. This report recommends a
      reasonable ethics course time to be 15-30 h while allowing each program the
      flexibility to design their course.
FAU - Serago, Christopher F
AU  - Serago CF
AD  - Department of Radiation Oncology, Mayo Clinic, Jacksonville, Florida 32224, USA. 
      serago.christopher@mayo.edu
FAU - Burmeister, Jay W
AU  - Burmeister JW
FAU - Dunscombe, Peter B
AU  - Dunscombe PB
FAU - Gale, Ashley A
AU  - Gale AA
FAU - Hendee, William R
AU  - Hendee WR
FAU - Kry, Stephen F
AU  - Kry SF
FAU - Wuu, Cheng-Shie
AU  - Wuu CS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Phys
JT  - Medical physics
JID - 0425746
SB  - IM
MH  - Curriculum/*standards
MH  - Education, Medical/*standards
MH  - Education, Medical, Graduate/*standards
MH  - Health Physics/*education/*standards
MH  - Internship and Residency/*standards
MH  - United States
EDAT- 2010/10/01 06:00
MHDA- 2010/11/16 06:00
CRDT- 2010/10/01 06:00
PHST- 2010/10/01 06:00 [entrez]
PHST- 2010/10/01 06:00 [pubmed]
PHST- 2010/11/16 06:00 [medline]
AID - 10.1118/1.3451116 [doi]
PST - ppublish
SO  - Med Phys. 2010 Aug;37(8):4495-500. doi: 10.1118/1.3451116.


PMID- 20879576
OWN - NLM
STAT- MEDLINE
DCOM- 20101115
LR  - 20211020
IS  - 0094-2405 (Print)
IS  - 0094-2405 (Linking)
VI  - 37
IP  - 8
DP  - 2010 Aug
TI  - Enhancement of breast CADx with unlabeled data.
PG  - 4155-72
AB  - PURPOSE: Unlabeled medical image data are abundant, yet the process of converting
      them into a labeled ("truth-known") database is time and resource expensive and
      fraught with ethical and logistics issues. The authors propose a dual-stage CADx 
      scheme in which both labeled and unlabeled (truth-known and "truth-unknown") data
      are used. This study is an initial exploration of the potential for leveraging
      unlabeled data toward enhancing breast CADx. METHODS: From a labeled ultrasound
      image database consisting of 1126 lesions with an empirical cancer prevalence of 
      14%, 200 different randomly sampled subsets were selected and the truth status of
      a variable number of cases was masked to the algorithm to mimic different types
      of labeled and unlabeled data sources. The prevalence was fixed at 50% cancerous 
      for the labeled data and 5% cancerous for the unlabeled. In the first stage of
      the dual-stage CADx scheme, the authors term "transductive dimension reduction
      regularization" (TDR-R), both labeled and unlabeled images characterized by
      extracted lesion features were combined using dimension reduction (DR) techniques
      and mapped to a lower-dimensional representation. (The first stage ignored truth 
      status therefore was an unsupervised algorithm.) In the second stage, the labeled
      data from the reduced dimension embedding were used to train a classifier toward 
      estimating the probability of malignancy. For the first CADx stage, the authors
      investigated three DR approaches: Laplacian eigen-maps, t-distributed stochastic 
      neighbor embedding (t-SNE), and principal component analysis. For the TDR-R
      methods, the classifier in the second stage was a supervised (i.e., utilized
      truth) Bayesian neural net. The dual-stage CADx schemes were compared to a
      single-stage scheme based on manifold regularization (MR) in a semisupervised
      setting via the LapSVM algorithm. Performance in terms of areas under the ROC
      curve (AUC) of the CADx schemes was evaluated in leave-one-out and .632+
      bootstrap analyses on a by-lesion basis. Additionally, the trained algorithms
      were applied to an independent test data set consisting of 101 lesions with
      approximately 50% cancer prevalence. The difference in AUC (deltaAUC) between
      with and without the use of unlabeled data was computed. RESULTS: Statistically
      significant differences in the average AUC value (deltaAUC) were found in many
      instances between training with and without unlabeled data, based on the sample
      set distributions generated from this particular ultrasound data set during
      cross-validation and using independent test set. For example, when using 100
      labeled and 900 unlabeled cases and testing on the independent test set, the
      TDR-R methods produced average deltaAUC=0.0361 with 95% intervals [0.0301;
      0.0408] (p-value < 0.0001, adjusted for multiple comparisons, but considering the
      test set fixed) using t-SNE and average deltaAUC=.026 [0.0227, 0.0298] (adjusted 
      p-value < 0.0001) using Laplacian eigenmaps, while the MR-based LapSVM produced
      an average deltaAUC=.0381 [0.0351; 0.0405] (adjusted p-value < 0.0001). The
      authors also found that schemes initially obtaining lower than average
      performance when using labeled data only showed the most prominent increase in
      performance when unlabeled data were added in the first CADx stage, suggesting a 
      regularization effect due to the injection of unlabeled data. CONCLUSION: The
      findings reveal evidence that incorporating unlabeled data information into the
      overall development of CADx methods may improve classifier performance by
      non-negligible amounts and warrants further investigation.
FAU - Jamieson, Andrew R
AU  - Jamieson AR
AD  - Department of Radiology, University of Chicago, Illinois 60637, USA.
      andrewj@uchicago.edu
FAU - Giger, Maryellen L
AU  - Giger ML
FAU - Drukker, Karen
AU  - Drukker K
FAU - Pesce, Lorenzo L
AU  - Pesce LL
LA  - eng
GR  - P30 CA014599/CA/NCI NIH HHS/United States
GR  - S10 RR021039/RR/NCRR NIH HHS/United States
GR  - P30 CA14599/CA/NCI NIH HHS/United States
GR  - P50-CA125138/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Med Phys
JT  - Medical physics
JID - 0425746
SB  - IM
MH  - *Algorithms
MH  - Breast Neoplasms/*diagnostic imaging/*epidemiology
MH  - Documentation/*statistics & numerical data
MH  - Female
MH  - Humans
MH  - Image Enhancement/*methods
MH  - Image Interpretation, Computer-Assisted/*methods
MH  - Radiography
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Ultrasonography, Mammary/*statistics & numerical data
MH  - United States/epidemiology
PMC - PMC2921421
EDAT- 2010/10/01 06:00
MHDA- 2010/11/16 06:00
CRDT- 2010/10/01 06:00
PHST- 2010/10/01 06:00 [entrez]
PHST- 2010/10/01 06:00 [pubmed]
PHST- 2010/11/16 06:00 [medline]
AID - 10.1118/1.3455704 [doi]
PST - ppublish
SO  - Med Phys. 2010 Aug;37(8):4155-72. doi: 10.1118/1.3455704.


PMID- 23908784
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130805
LR  - 20211021
IS  - 2076-9172 (Print)
IS  - 2076-9172 (Linking)
VI  - 1
IP  - 2
DP  - 2010 Oct
TI  - Reflections on science and ethics.
PG  - e0012
LID - 10.5041/RMMJ.10012 [doi]
FAU - Wiesel, Elie
AU  - Wiesel E
AD  - Nobel Prize Laureate in Peace, 1986. Andrew W. Mellon Professor in the
      Humanities; Professor of Philosophy and Religion, Elie Wiesel Center for Judaic
      Studies, Boston University, Boston, USA. Distinguished Presidential Fellow at
      Chapman University, Orange, California, USA.
LA  - eng
PT  - Journal Article
DEP - 20101031
PL  - Israel
TA  - Rambam Maimonides Med J
JT  - Rambam Maimonides medical journal
JID - 101538065
PMC - PMC3678782
EDAT- 2010/10/01 00:00
MHDA- 2010/10/01 00:01
CRDT- 2013/08/03 06:00
PHST- 2013/08/03 06:00 [entrez]
PHST- 2010/10/01 00:00 [pubmed]
PHST- 2010/10/01 00:01 [medline]
AID - 10.5041/RMMJ.10012 [doi]
AID - rmmj-1-2_e0012 [pii]
PST - epublish
SO  - Rambam Maimonides Med J. 2010 Oct 31;1(2):e0012. doi: 10.5041/RMMJ.10012. Print
      2010 Oct.


PMID- 23898961
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130801
LR  - 20130731
IS  - 0738-0577 (Print)
IS  - 0738-0577 (Linking)
VI  - 24
IP  - 4
DP  - 2010 Oct
TI  - Accessibility of occupational therapy community services: a legal, ethical, and
      clinical analysis.
PG  - 360-76
LID - 10.3109/07380577.2010.510170 [doi]
AB  - ABSTRACT Accessibility of health care services is a major concern in many
      countries. This paper examines the impact of limited access to occupational
      therapy community services on the right to services, distributive justice
      (resource distribution based on social solidarity), and service quality. Legal
      documents and relevant scientific papers were analyzed from three standpoints:
      legal, ethical, and clinical. Random use of criteria to prioritize requests,
      partial response to complex needs, task delegation, and long waiting times, all
      affect distributive justice and compromise the right to and quality of services. 
      Various alternatives are suggested to ensure a balance between the distribution
      and quality of occupational therapy services.
FAU - Carrier, Annie
AU  - Carrier A
AD  - Annie Carrier is a Fonds de la recherche en sante du Quebec scholarship student
      (#13893) affiliated with the Research Centre on Aging, Health and Social Services
      Centre-University Institute of Geriatrics of Sherbrooke (CSSS-IUGS), Sherbrooke, 
      Quebec, Canada. She is a part-time lecturer in the School of Rehabilitation,
      Universite de Sherbrooke.
FAU - Levasseur, Melanie
AU  - Levasseur M
FAU - Mullins, Gary
AU  - Mullins G
LA  - eng
PT  - Journal Article
DEP - 20100824
PL  - England
TA  - Occup Ther Health Care
JT  - Occupational therapy in health care
JID - 8309883
EDAT- 2010/10/01 00:00
MHDA- 2010/10/01 00:01
CRDT- 2013/08/01 06:00
PHST- 2013/08/01 06:00 [entrez]
PHST- 2010/10/01 00:00 [pubmed]
PHST- 2010/10/01 00:01 [medline]
AID - 10.3109/07380577.2010.510170 [doi]
PST - ppublish
SO  - Occup Ther Health Care. 2010 Oct;24(4):360-76. doi: 10.3109/07380577.2010.510170.
      Epub 2010 Aug 24.


PMID- 23270032
OWN - NLM
STAT- MEDLINE
DCOM- 20130116
LR  - 20121228
IS  - 0038-3139 (Print)
IS  - 0038-3139 (Linking)
VI  - 106
IP  - 6
DP  - 2010 Oct
TI  - Resolving the shortage of organs for transplantation: ethics, science, and
      technology.
PG  - 209-12
FAU - Brockbank, Kelvin G M
AU  - Brockbank KG
FAU - Swaja, Richard E
AU  - Swaja RE
FAU - Wueste, Daniel E
AU  - Wueste DE
FAU - Sade, Robert M
AU  - Sade RM
LA  - eng
PT  - Consensus Development Conference
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J S C Med Assoc
JT  - Journal of the South Carolina Medical Association (1975)
JID - 7503045
SB  - IM
MH  - Biomedical Research
MH  - Humans
MH  - *Organ Transplantation/ethics/statistics & numerical data
MH  - Regenerative Medicine
MH  - Tissue and Organ Procurement/organization & administration
MH  - Transplantation, Heterologous
EDAT- 2010/10/01 00:00
MHDA- 2013/01/17 06:00
CRDT- 2012/12/29 06:00
PHST- 2012/12/29 06:00 [entrez]
PHST- 2010/10/01 00:00 [pubmed]
PHST- 2013/01/17 06:00 [medline]
PST - ppublish
SO  - J S C Med Assoc. 2010 Oct;106(6):209-12.


PMID- 22810609
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20120719
IS  - 1080-2371 (Print)
IS  - 1080-2371 (Linking)
VI  - 16
IP  - 5 Multiple Sclerosis
DP  - 2010 Oct
TI  - Ethical perspectives in neurology: ethical considerations when doctor and patient
      perspectives on treatment risks differ.
PG  - 234-7
LID - 10.1212/01.CON.0000389947.12477.85 [doi]
FAU - Conway, Jill
AU  - Conway J
FAU - Kachuck, Norman J
AU  - Kachuck NJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Continuum (Minneap Minn)
JT  - Continuum (Minneapolis, Minn.)
JID - 9509333
EDAT- 2010/10/01 00:00
MHDA- 2010/10/01 00:01
CRDT- 2012/07/20 06:00
PHST- 2012/07/20 06:00 [entrez]
PHST- 2010/10/01 00:00 [pubmed]
PHST- 2010/10/01 00:01 [medline]
AID - 10.1212/01.CON.0000389947.12477.85 [doi]
AID - 00132979-201010000-00018 [pii]
PST - ppublish
SO  - Continuum (Minneap Minn). 2010 Oct;16(5 Multiple Sclerosis):234-7. doi:
      10.1212/01.CON.0000389947.12477.85.


PMID- 22778709
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1555-5194 (Electronic)
IS  - 1550-5952 (Linking)
VI  - 7
IP  - 10
DP  - 2010 Oct
TI  - Civil commitment in the United States.
PG  - 30-40
AB  - This article reviews the academic literature on the psychiatric practice of civil
      commitment. It provides an overview of the history of involuntary psychiatric
      hospitalization in the United States-from the creation of the first asylum and
      the era of institutionalization to the movement of deinstitutionalization. The
      ethical conflict that the practice of involuntary hospitalization presents for
      providers, namely the conflict between the ethical duties of beneficence and
      respect for patient autonomy, is presented. The evolution of the United States
      commitment standards, from being based on a right to treatment for patients with 
      mental illness to being based on dangerousness, as well as the implications that 
      the changes in commitment criteria has had on patients and society, are
      discussed. Involuntary hospitalization of patient populations that present unique
      challenges for psychiatry (e.g., not guilty by reason of insanity acquittees, sex
      offenders, and individuals with eating disorders, substance use disorders, and
      personality disorders) is discussed. Finally, an overview of outpatient
      commitment is provided. By reading this article, one will learn the history of
      involuntary psychiatric hospitalization in the United States and gain an
      understanding of the ethical issues that make civil commitment one of the most
      controversial practices in modern psychiatry.
FAU - Testa, Megan
AU  - Testa M
AD  - Dr. Testa is from University Hospitals Case Medical Center, Cleveland, Ohio.
FAU - West, Sara G
AU  - West SG
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Psychiatry (Edgmont)
JT  - Psychiatry (Edgmont (Pa. : Township))
JID - 101484252
PMC - PMC3392176
OTO - NOTNLM
OT  - Civil commitment
OT  - deinstitutionalization
OT  - institutionalization
OT  - involuntary hospitalization
EDAT- 2010/10/01 00:00
MHDA- 2010/10/01 00:01
CRDT- 2012/07/11 06:00
PHST- 2012/07/11 06:00 [entrez]
PHST- 2010/10/01 00:00 [pubmed]
PHST- 2010/10/01 00:01 [medline]
PST - ppublish
SO  - Psychiatry (Edgmont). 2010 Oct;7(10):30-40.


PMID- 22455248
OWN - NLM
STAT- MEDLINE
DCOM- 20120419
LR  - 20120329
IS  - 1025-9589 (Print)
IS  - 1025-9589 (Linking)
VI  - 22
IP  - 4
DP  - 2010 Oct-Dec
TI  - Research ethics need consideration.
PG  - 1-2
FAU - Rashid, Abdul
AU  - Rashid A
FAU - Ayub, Muhammad
AU  - Ayub M
FAU - Wazir, Mohammad Salim
AU  - Wazir MS
LA  - eng
PT  - Editorial
PL  - Pakistan
TA  - J Ayub Med Coll Abbottabad
JT  - Journal of Ayub Medical College, Abbottabad : JAMC
JID - 8910750
SB  - IM
MH  - *Ethics, Research
MH  - Guidelines as Topic
MH  - Humans
MH  - Publishing/ethics/*standards
EDAT- 2010/10/01 00:00
MHDA- 2012/04/20 06:00
CRDT- 2012/03/30 06:00
PHST- 2012/03/30 06:00 [entrez]
PHST- 2010/10/01 00:00 [pubmed]
PHST- 2012/04/20 06:00 [medline]
PST - ppublish
SO  - J Ayub Med Coll Abbottabad. 2010 Oct-Dec;22(4):1-2.


PMID- 20879091
OWN - NLM
STAT- MEDLINE
DCOM- 20101014
LR  - 20190612
IS  - 1474-547X (Electronic)
IS  - 0140-6736 (Linking)
VI  - 376
IP  - 9746
DP  - 2010 Sep 25
TI  - The ethical challenges of surgical innovation for patient care.
PG  - 1046-7
FAU - Angelos, Peter
AU  - Angelos P
LA  - eng
PT  - News
PL  - England
TA  - Lancet
JT  - Lancet (London, England)
JID - 2985213R
SB  - IM
MH  - Biomedical Technology/ethics
MH  - Education, Medical, Continuing
MH  - Ethics, Clinical
MH  - Ethics, Medical
MH  - Evidence-Based Medicine
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Patient Care/*ethics
MH  - Risk
MH  - Safety
MH  - Surgical Procedures, Operative/*ethics/*methods/standards
MH  - Thyroidectomy/ethics/methods
EDAT- 2010/09/30 06:00
MHDA- 2010/10/15 06:00
CRDT- 2010/09/30 06:00
PHST- 2010/09/30 06:00 [entrez]
PHST- 2010/09/30 06:00 [pubmed]
PHST- 2010/10/15 06:00 [medline]
AID - S0140-6736(10)61474-2 [pii]
AID - 10.1016/s0140-6736(10)61474-2 [doi]
PST - ppublish
SO  - Lancet. 2010 Sep 25;376(9746):1046-7. doi: 10.1016/s0140-6736(10)61474-2.


PMID- 20879084
OWN - NLM
STAT- MEDLINE
DCOM- 20100929
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 7
IP  - 3
DP  - 2010 Jul-Sep
TI  - Why raise questions on the "ethics" of the Gadchiroli trial?
PG  - 193-4
FAU - Kumar, Kuldeep
AU  - Kumar K
LA  - eng
PT  - Comment
PT  - Letter
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
CON - Indian J Med Ethics. 2010 Jan-Mar;7(1):12-4. PMID: 20166288
MH  - Asia
MH  - *Community Health Workers
MH  - *Home Care Services
MH  - Humans
MH  - India
MH  - Infant Mortality
MH  - Infant, Newborn
MH  - Randomized Controlled Trials as Topic/*ethics
MH  - *Rural Health
EDAT- 2010/09/30 06:00
MHDA- 2010/09/30 06:01
CRDT- 2010/09/30 06:00
PHST- 2010/09/30 06:00 [entrez]
PHST- 2010/09/30 06:00 [pubmed]
PHST- 2010/09/30 06:01 [medline]
AID - 10.20529/IJME.2010.073 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2010 Jul-Sep;7(3):193-4. doi: 10.20529/IJME.2010.073.


PMID- 20878738
OWN - NLM
STAT- MEDLINE
DCOM- 20101028
LR  - 20100929
IS  - 1097-4598 (Electronic)
IS  - 0148-639X (Linking)
VI  - 42
IP  - 4
DP  - 2010 Oct
TI  - Guidelines for ethical behavior relating to clinical practice issues in
      neuromuscular and electrodiagnostic medicine.
PG  - 480-6
LID - 10.1002/mus.21761 [doi]
FAU - Leonard, James A Jr
AU  - Leonard JA Jr
FAU - Abel, Naomi
AU  - Abel N
FAU - Cochrane, Thomas
AU  - Cochrane T
FAU - Denys, Eric
AU  - Denys E
FAU - Goldman, Ed
AU  - Goldman E
FAU - Musick, David W
AU  - Musick DW
FAU - Simpson, David
AU  - Simpson D
FAU - Swisher, Karen
AU  - Swisher K
CN  - American Association of Neuromuscular and Electrodiagnostic Medicine (AANEM)
LA  - eng
PT  - Journal Article
PT  - Practice Guideline
PL  - United States
TA  - Muscle Nerve
JT  - Muscle & nerve
JID - 7803146
SB  - IM
MH  - Biomedical Research/ethics
MH  - *Codes of Ethics
MH  - Communication
MH  - Conflict of Interest
MH  - Electrodiagnosis/*ethics
MH  - Humans
MH  - Informed Consent
MH  - Interdisciplinary Communication
MH  - Neurology/*ethics
MH  - *Neuromuscular Diseases/diagnosis/therapy
MH  - Patient Care/ethics
MH  - Physician-Patient Relations
MH  - Referral and Consultation/ethics
EDAT- 2010/09/30 06:00
MHDA- 2010/10/29 06:00
CRDT- 2010/09/30 06:00
PHST- 2010/09/30 06:00 [entrez]
PHST- 2010/09/30 06:00 [pubmed]
PHST- 2010/10/29 06:00 [medline]
AID - 10.1002/mus.21761 [doi]
PST - ppublish
SO  - Muscle Nerve. 2010 Oct;42(4):480-6. doi: 10.1002/mus.21761.


PMID- 20878735
OWN - NLM
STAT- MEDLINE
DCOM- 20101028
LR  - 20100929
IS  - 1097-4598 (Electronic)
IS  - 0148-639X (Linking)
VI  - 42
IP  - 4
DP  - 2010 Oct
TI  - For the good of our patients: the new ethical guidelines of the AANEM.
PG  - 465
LID - 10.1002/mus.21888 [doi]
FAU - Larriviere, Dan
AU  - Larriviere D
LA  - eng
PT  - Editorial
PL  - United States
TA  - Muscle Nerve
JT  - Muscle & nerve
JID - 7803146
SB  - IM
MH  - Certification
MH  - Education, Medical, Continuing
MH  - Electrodiagnosis/*ethics
MH  - *Ethics, Medical/education
MH  - Humans
MH  - Neurology/*ethics
MH  - *Neuromuscular Diseases/diagnosis
MH  - *Practice Guidelines as Topic
MH  - Societies, Medical
MH  - United States
EDAT- 2010/09/30 06:00
MHDA- 2010/10/29 06:00
CRDT- 2010/09/30 06:00
PHST- 2010/09/30 06:00 [entrez]
PHST- 2010/09/30 06:00 [pubmed]
PHST- 2010/10/29 06:00 [medline]
AID - 10.1002/mus.21888 [doi]
PST - ppublish
SO  - Muscle Nerve. 2010 Oct;42(4):465. doi: 10.1002/mus.21888.


PMID- 20878302
OWN - NLM
STAT- MEDLINE
DCOM- 20110322
LR  - 20211020
IS  - 1615-6722 (Electronic)
IS  - 0723-5003 (Linking)
VI  - 105
IP  - 9
DP  - 2010 Sep
TI  - [Assessment of immunoglobulins in a long-term non-interventional study (SIGNS
      Study). Rationale, design, and methods].
PG  - 647-51
LID - 10.1007/s00063-010-1105-8 [doi]
AB  - Non-modified human immunoglobulins (IgG) are standard of care for replacement
      therapy with primary (inherited) immunodeficiencies, and secondary
      immunodeficiencies due to multiple myeloma (MM) or chronic lymphocytic leukemia
      (CLL). Further, they have effectively been used as immunomodulation in
      neurological autoimmune diseases such as Guillain-Barre syndrome (GBS), chronic
      inflammatory demyelinating polyneuropathy (CIDP), and multifocal motor neuropathy
      (MMN). A variety of IgG preparations for intravenous and subcutaneous use are
      available. In view of the broad range of indications, data on the utilization of 
      the IgG preparations in everyday clinical care are of high clinical interest.
      Furthermore, data on the outcomes of IgG therapy outside the setting of
      controlled clinical trials are needed. Therefore, the SIGNS study (Assessment of 
      Immunoglobulins in a Long-Term Non-Interventional Study) was set up as a
      non-interventional prospective open-label cohort study and was approved by the
      ethics committee. Led by an interdisciplinary steering board, hospital- and
      office-based investigators in 30-40 centers throughout Germany (neurologists,
      pediatricians, oncologists, other) will document approximately 300 patients, and 
      will follow them for at least 2 years. Patients of both genders and any age are
      eligible if they have received, or are scheduled for, IgG therapy for primary or 
      severe secondary immunodeficiency or neurological autoimmune diseases, and have
      provided written informed consent. No exclusion criteria have been defined in
      order to minimize selection bias. Long-term outcome data will be collected on
      patient characteristics in the various indications, drug utilization (e.g.,
      treatment and dosing patterns), effectiveness (i.e., number of infections),
      tolerability, health-related quality of life, and economic variables (number of
      hospitalizations, sick-leave days, etc.) with the possibility to estimate direct 
      costs. For the neurological autoimmune diseases, detailed data will be gathered, 
      among others, on neurological function, muscular function, physical function
      (grip strength, INCAT disability scale, etc.) and stabilization or progression of
      symptoms over time. Data collection in SIGNS is performed using a secure internet
      site and an MySQL database. A number of quality measures are routinely performed 
      including automated plausibility checks at data entry, queries, and on-site
      monitoring with source data verification. It is expected that SIGNS will
      contribute to optimization of therapy in this diverse patient population.
FAU - Kirch, Wilhelm
AU  - Kirch W
AD  - Institut fur Klinische Pharmakologie, Medizinische Fakultat, Technische
      Universitat Dresden, Dresden, Germany. Wilhelm.kirch@mailbox.tu-dresden.de
FAU - Gold, Ralf
AU  - Gold R
FAU - Hensel, Manfred
AU  - Hensel M
FAU - Fasshauer, Maria
AU  - Fasshauer M
FAU - Pittrow, David
AU  - Pittrow D
FAU - Huscher, Dorte
AU  - Huscher D
FAU - Reiser, Marcel
AU  - Reiser M
FAU - Stangel, Martin
AU  - Stangel M
FAU - Baumann, Ulrich
AU  - Baumann U
FAU - Borte, Michael
AU  - Borte M
LA  - ger
PT  - Journal Article
TT  - Prospektive Versorgungsforschungsstudie zur Therapie mit Immunglobulinen (SIGNS):
      Rationale, Design und Methodik.
DEP - 20100928
PL  - Germany
TA  - Med Klin (Munich)
JT  - Medizinische Klinik (Munich, Germany : 1983)
JID - 8303501
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Adult
MH  - Child
MH  - Cohort Studies
MH  - Follow-Up Studies
MH  - Germany
MH  - Humans
MH  - IgG Deficiency/*drug therapy/genetics
MH  - Immunoglobulin G/*therapeutic use
MH  - Long-Term Care
MH  - Outcome Assessment, Health Care
MH  - Prospective Studies
MH  - Quality of Life
EDAT- 2010/09/30 06:00
MHDA- 2011/03/23 06:00
CRDT- 2010/09/30 06:00
PHST- 2010/06/02 00:00 [received]
PHST- 2010/07/09 00:00 [accepted]
PHST- 2010/09/30 06:00 [entrez]
PHST- 2010/09/30 06:00 [pubmed]
PHST- 2011/03/23 06:00 [medline]
AID - 10.1007/s00063-010-1105-8 [doi]
PST - ppublish
SO  - Med Klin (Munich). 2010 Sep;105(9):647-51. doi: 10.1007/s00063-010-1105-8. Epub
      2010 Sep 28.


PMID- 20878106
OWN - NLM
STAT- MEDLINE
DCOM- 20110218
LR  - 20190606
IS  - 1791-2431 (Electronic)
IS  - 1021-335X (Linking)
VI  - 24
IP  - 5
DP  - 2010 Nov
TI  - Non-surgical care for locally advanced breast cancer: radiologically assessed
      therapeutic outcome of a new enzyme-targeting radiosensitization treatment, Kochi
      Oxydol-Radiation Therapy for Unresectable Carcinomas, Type II (KORTUC II) with
      systemic chemotherapy.
PG  - 1161-8
AB  - We have previously developed a new enzyme-targeting radiosensitization treatment 
      named Kochi Oxydol-Radiation Therapy for Unresectable Carcinomas, Type II (KORTUC
      II), which markedly enhances radiotherapeutic effects on various types of locally
      advanced malignant neoplasms. KORTUC II was approved by our local ethics
      committee for use against various types of malignant neoplasms. A maximum of 6 ml
      of radiosensitizer was injected into tumor tissue under ultrasonographic guidance
      just before each administration of radiotherapy. Seventeen patients with locally 
      advanced breast cancer were enrolled to receive KORTUC II with systemic
      chemotherapy without surgical care. Patients were eligible if they had declined
      surgical treatment. Median observation period was 13.4 months (range, 1-26
      months). This therapy was well tolerated. Contrast-enhanced magnetic resonance
      imaging revealed complete response in all primary breast tumors, and no patients 
      displayed local recurrence during the follow-up period. Ultrasonography depicted 
      tumor-like findings in 9 of 17 cases after therapy. The existence rate of
      posterior shadow artifacts behind the tumor was 2/17 before therapy, increasing
      to 8/17 after therapy. Intratumoral flow signals on color Doppler sonography were
      seen in 16/17 cases before therapy, but had disappeared from all cases after
      therapy. The increased rate of posterior shadow artifacts and absence of flow
      signals after therapy suggest that the tumor-like finding on ultrasonography
      represents scar tissue. Computed tomography revealed positive axillary nodes
      metastases in 16/17 and 2/17 cases before and after therapy, respectively. Nodal 
      metastatic failure affected only 1 patient, who refused adjuvant systemic
      chemotherapy at the end of the observation period. Abnormal lymph node findings
      on computed tomography remained stable in the other patient. Excellent
      locoregional control based on accurate radiological evaluation implies that
      KORTUC II with chemotherapy has the potential to replace surgery in therapy for
      locally advanced breast cancer.
FAU - Miyatake, Kana
AU  - Miyatake K
AD  - Department of Radiology, Kochi Medical School, Kochi University, Nankoku, Kochi
      783-8505, Japan. jm-kanakana@kochi-u.ac.jp
FAU - Kubota, Kei
AU  - Kubota K
FAU - Ogawa, Yasuhiro
AU  - Ogawa Y
FAU - Hamada, Norihiko
AU  - Hamada N
FAU - Murata, Yoriko
AU  - Murata Y
FAU - Nishioka, Akihito
AU  - Nishioka A
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Oncol Rep
JT  - Oncology reports
JID - 9422756
RN  - 0 (Radiation-Sensitizing Agents)
RN  - 9004-61-9 (Hyaluronic Acid)
RN  - BBX060AN9V (Hydrogen Peroxide)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Breast Neoplasms/diagnostic imaging/drug therapy/pathology/*radiotherapy
MH  - Carcinoma, Ductal, Breast/diagnostic imaging/drug therapy/pathology/radiotherapy
MH  - Chemotherapy, Adjuvant
MH  - Female
MH  - Humans
MH  - Hyaluronic Acid/administration & dosage
MH  - Hydrogen Peroxide/administration & dosage
MH  - Middle Aged
MH  - Positron-Emission Tomography
MH  - Radiation-Sensitizing Agents/*administration & dosage
MH  - Radiotherapy Dosage
MH  - Radiotherapy, High-Energy
MH  - Treatment Outcome
EDAT- 2010/09/30 06:00
MHDA- 2011/02/22 06:00
CRDT- 2010/09/30 06:00
PHST- 2010/09/30 06:00 [entrez]
PHST- 2010/09/30 06:00 [pubmed]
PHST- 2011/02/22 06:00 [medline]
AID - 10.3892/or_00000968 [doi]
PST - ppublish
SO  - Oncol Rep. 2010 Nov;24(5):1161-8. doi: 10.3892/or_00000968.


PMID- 20877474
OWN - NLM
STAT- MEDLINE
DCOM- 20110118
LR  - 20211020
IS  - 1549-1676 (Electronic)
IS  - 1549-1277 (Linking)
VI  - 7
IP  - 9
DP  - 2010 Sep 21
TI  - AIDS vaccine for Asia Network (AVAN): expanding the regional role in developing
      HIV vaccines.
PG  - e1000331
LID - 10.1371/journal.pmed.1000331 [doi]
LID - e1000331 [pii]
AB  - The HIV/AIDS pandemic continues to spread and an AIDS vaccine is urgently needed.
      Regional alliances and international collaborations can foster the development
      and evaluation of the next generation of AIDS vaccine candidates. The importance 
      of coordinating and harmonizing efforts across regional alliances has become
      abundantly clear. We recently formed the AIDS Vaccine for Asia Network (AVAN) to 
      help facilitate the development of a regional AIDS vaccine strategy that
      accelerates research and development of an AIDS vaccine through government
      advocacy, improved coordination, and harmonization of research; develops clinical
      trial and manufacturing capacity; supports ethical and regulatory frameworks; and
      ensures community participation.
FAU - Kent, Stephen J
AU  - Kent SJ
AD  - University of Melbourne, Parkville, Victoria, Australia.
FAU - Cooper, David A
AU  - Cooper DA
FAU - Chhi Vun, Mean
AU  - Chhi Vun M
FAU - Shao, Yiming
AU  - Shao Y
FAU - Zhang, Linqi
AU  - Zhang L
FAU - Ganguly, Nirmal
AU  - Ganguly N
FAU - Bela, Budiman
AU  - Bela B
FAU - Tamashiro, Hiko
AU  - Tamashiro H
FAU - Ditangco, Rossana
AU  - Ditangco R
FAU - Rerks-Ngarm, Supachai
AU  - Rerks-Ngarm S
FAU - Pitisuttithum, Punnee
AU  - Pitisuttithum P
FAU - Van Kinh, Nguyen
AU  - Van Kinh N
FAU - Bernstein, Alan
AU  - Bernstein A
FAU - Osmanov, Saladin
AU  - Osmanov S
CN  - AIDS Vaccine for Asia Network investigators and supporters
LA  - eng
PT  - Journal Article
DEP - 20100921
PL  - United States
TA  - PLoS Med
JT  - PLoS medicine
JID - 101231360
RN  - 0 (AIDS Vaccines)
SB  - IM
MH  - *AIDS Vaccines
MH  - Asia
MH  - Biomedical Research
MH  - Clinical Trials as Topic
MH  - Global Health
MH  - HIV Infections/immunology/*prevention & control
MH  - Humans
MH  - International Cooperation
MH  - Pandemics
PMC - PMC2943436
IR  - Chen Z
FIR - Chen, Zhiwei
IR  - Esparza J
FIR - Esparza, Jose
IR  - Excler JL
FIR - Excler, Jean-Louis
IR  - Flores J
FIR - Flores, Jorge
IR  - Hankins C
FIR - Hankins, Cate
IR  - Ibrahim F
FIR - Ibrahim, Fera
IR  - Kaufman J
FIR - Kaufman, Joan
IR  - Kochhar S
FIR - Kochhar, Sonali
IR  - Mathieson B
FIR - Mathieson, Bonnie
IR  - Mehandale S
FIR - Mehandale, Sanjay
IR  - Nguyen VK
FIR - Nguyen, Van Kinh
IR  - Ruxrungtham K
FIR - Ruxrungtham, Kiat
IR  - Sandstrom E
FIR - Sandstrom, Eric
IR  - Truong XL
FIR - Truong, Xuan Lien
IR  - Yamamoto N
FIR - Yamamoto, Naoki
IR  - France T
FIR - France, Tim
IR  - Teng T
FIR - Teng, Tao
IR  - Liang H
FIR - Liang, Hua
IR  - Xin X
FIR - Xin, Xin
EDAT- 2010/09/30 06:00
MHDA- 2011/01/19 06:00
CRDT- 2010/09/30 06:00
PHST- 2010/09/30 06:00 [entrez]
PHST- 2010/09/30 06:00 [pubmed]
PHST- 2011/01/19 06:00 [medline]
AID - 10.1371/journal.pmed.1000331 [doi]
PST - epublish
SO  - PLoS Med. 2010 Sep 21;7(9):e1000331. doi: 10.1371/journal.pmed.1000331.


PMID- 20877273
OWN - NLM
STAT- MEDLINE
DCOM- 20110330
LR  - 20160210
IS  - 2329-0358 (Electronic)
IS  - 1425-9524 (Linking)
VI  - 15
IP  - 3
DP  - 2010 Jul-Sep
TI  - Composite tissue allotransplantation in Europe. Logistics and infrastructure of a
      centre.
PG  - 87-92
AB  - BACKGROUND: Composite Tissue Allotransplantation (CTA) is a new medical field of 
      growing importance. This paper focuses on the infrastructure and organisation of 
      European CTA centres and discusses the differences between national health
      systems. MATERIAL/METHODS: Eight European centres (Valencia, Innsbruck, Munich,
      Lyon, Amiens, Creteil, Wroclaw, Monza) were sent with a specially-designed,
      standardized, 20-item questionnaire. RESULTS: Five of the eight centres returned 
      our questionnaire: Munich, Innsbruck, Lyon, Amiens, Wroclaw. Since 1998, CTA has 
      been performed at these centres. In both French centres and the Polish centre
      public funding is available in addition to the coverage provided by health
      insurers. In Munich the costs for a double upper-arm transplantation were Euro
      150,000 with an additional Euro 50,000-70,000 per year. In Lyon the costs for a
      singular hand transplantation were Euro 70,000 per year and in Wroclaw (Poland)
      the costs for a hand or upper arm transplantation were Euro 20,000-30,000. As
      many as 17 different medical professions are involved in the CTA at the different
      centres. CONCLUSIONS: CTA is an innovative promising therapeutic tool that is
      based on the experiences of solid organ transplantation and profound
      microsurgical skills. Due to the complexity of the infrastructure, sourcing and
      the organisation CTA can only be successfully performed at specialized centres. A
      European network with an international European waiting list and a central
      coordination for CTA should be established. In order to advance CTA as an
      important tool in reconstructive surgery we must turn our attention to how the
      costs will be met, the legal environment for procurement of adequate donors and
      open ethical questions.
FAU - Meyer-Marcotty, Max
AU  - Meyer-Marcotty M
AD  - Department of Plastic Surgery, Hand Surgery, Reconstructive Surgery, Hannover
      Medical School, Germany. maxmeyermarcotty@gmx.de
FAU - Rennekampff, Hans
AU  - Rennekampff H
FAU - Haerle, Max
AU  - Haerle M
FAU - Knobloch, Karsten
AU  - Knobloch K
FAU - Vogt, Peter
AU  - Vogt P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Ann Transplant
JT  - Annals of transplantation
JID - 9802544
SB  - IM
MH  - Arm/transplantation
MH  - Europe
MH  - Follow-Up Studies
MH  - Hand Transplantation
MH  - Health Facilities/economics/legislation & jurisprudence/*trends
MH  - Health Facility Administration
MH  - Humans
MH  - Reconstructive Surgical Procedures
MH  - Tissue Transplantation/economics/ethics/legislation & jurisprudence/*methods
MH  - Tissue and Organ Procurement/ethics/legislation & jurisprudence
EDAT- 2010/09/30 06:00
MHDA- 2011/03/31 06:00
CRDT- 2010/09/30 06:00
PHST- 2010/09/30 06:00 [entrez]
PHST- 2010/09/30 06:00 [pubmed]
PHST- 2011/03/31 06:00 [medline]
AID - 881176 [pii]
PST - ppublish
SO  - Ann Transplant. 2010 Jul-Sep;15(3):87-92.


PMID- 20876734
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20201216
IS  - 1879-0844 (Electronic)
IS  - 1388-9842 (Linking)
VI  - 12
IP  - 12
DP  - 2010 Dec
TI  - Improved pharmacological therapy of chronic heart failure in primary care: a
      randomized Study of NT-proBNP Guided Management of Heart Failure--SIGNAL-HF
      (Swedish Intervention study--Guidelines and NT-proBNP AnaLysis in Heart Failure).
PG  - 1300-8
LID - 10.1093/eurjhf/hfq169 [doi]
AB  - AIMS: Treatment of chronic heart failure (CHF) guided by natriuretic peptides has
      been studied in clinical trials with conflicting results. The aim of this study
      was to investigate if N-terminal pro-B-type natriuretic peptide
      (NT-proBNP)-guided therapy in symptomatic heart failure patients in primary care 
      would improve clinical outcomes over and above treatment according to guidelines.
      METHODS AND RESULTS: SIGNAL-HF was a 9 month, randomized, single-blind, parallel 
      group study in patients with CHF in NYHA class II-IV, ejection fraction (EF)<50% 
      and elevated NT-proBNP levels (males>800, females>1000 ng/L). All investigators
      underwent a pre-study educational programme about current CHF guidelines. A
      control group managed by non-trained investigators was considered not possible
      for ethical and practical reasons. Patients were randomized to structured
      treatment of CHF according to guidelines with or without NT-proBNP monitoring.
      The choice and dose of therapy for CHF was at the investigator's discretion. The 
      primary outcome variable was the composite endpoint of days alive, days out of
      hospital, and symptom score from the Kansas City Cardiomyopathy Questionnaire. In
      all, 252 patients were randomized. The allocation groups were well balanced with 
      regards to age, NT-proBNP, and EF. Treatment doses of beta-blockers and blockers 
      of the renin-angiotensin-aldosterone system were markedly increased towards
      target doses and to a similar degree in both groups. There were no differences
      between the groups concerning either the primary endpoint (P=0.28) or its
      components [cardiovascular (CV) death, P=0.93; CV hospitalization, P=0.88; or
      symptom score, P=0.28]. CONCLUSION: NT-proBNP-guided CHF treatment did not result
      in important improvements in clinical outcomes in patients with CHF in primary
      care above and beyond what could be achieved by education and structured CHF
      treatment according to guidelines.
FAU - Persson, Hans
AU  - Persson H
AD  - Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet,
      Stockholm, Sweden. hans.persson@ds.se
FAU - Erntell, Hans
AU  - Erntell H
FAU - Eriksson, Bjorn
AU  - Eriksson B
FAU - Johansson, Gunilla
AU  - Johansson G
FAU - Swedberg, Karl
AU  - Swedberg K
FAU - Dahlstrom, Ulf
AU  - Dahlstrom U
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20100928
PL  - England
TA  - Eur J Heart Fail
JT  - European journal of heart failure
JID - 100887595
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Biomarkers)
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
CIN - Eur J Heart Fail. 2010 Dec;12(12):1265-7. PMID: 21098577
MH  - Aged
MH  - Antihypertensive Agents/therapeutic use
MH  - Biomarkers
MH  - Female
MH  - Health Status Indicators
MH  - Heart Failure/blood/*drug therapy
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Natriuretic Peptide, Brain/*blood
MH  - Peptide Fragments/*blood
MH  - *Primary Health Care
MH  - Prognosis
MH  - Single-Blind Method
MH  - Statistics as Topic
MH  - Surveys and Questionnaires
MH  - Sweden
EDAT- 2010/09/30 06:00
MHDA- 2011/06/03 06:00
CRDT- 2010/09/30 06:00
PHST- 2010/09/30 06:00 [entrez]
PHST- 2010/09/30 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
AID - hfq169 [pii]
AID - 10.1093/eurjhf/hfq169 [doi]
PST - ppublish
SO  - Eur J Heart Fail. 2010 Dec;12(12):1300-8. doi: 10.1093/eurjhf/hfq169. Epub 2010
      Sep 28.


PMID- 20876722
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20220317
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 257
IP  - 2
DP  - 2010 Nov
TI  - Cardiovascular disease: prediction with ancillary aortic findings on chest CT
      scans in routine practice.
PG  - 549-59
LID - 10.1148/radiol.10100054 [doi]
AB  - PURPOSE: To predict cardiovascular disease (CVD) in a clinical care population by
      using prevalent subclinical ancillary aortic findings detected on chest computed 
      tomographic (CT) images. MATERIALS AND METHODS: The study was approved by the
      medical ethics committee of the primary participating facility and the
      institutional review boards of all other participating centers. From a total of
      6975 patients who underwent diagnostic contrast material-enhanced chest CT for
      noncardiovascular indications, a representative sample population of 817 patients
      plus 347 patients who experienced a cardiovascular event during a mean follow-up 
      period of 17 months were assigned visual scores for ancillary aortic
      abnormalities--on a scale of 0-8 for calcifications, a scale of 0-4 for plaques, 
      a scale of 0-4 for irregularities, and a scale of 0-1 for elongation. Four Cox
      proportional hazard models incorporating different sum scores for the aortic
      abnormalities plus age, sex, and chest CT indication were compared for
      discrimination and calibration. The prediction model that performed best was
      chosen and externally validated. RESULTS: Each aortic abnormality was highly
      predictive, and all models performed well (c index range, 0.70-0.72;
      goodness-of-fit P value range, .45-.76). The prediction model incorporating the
      sum score for aortic calcifications was chosen owing to its good performance (c
      index, 0.72; goodness-of-fit P = .47) and its applicability to nonenhanced CT
      scanning. Validation of this model in an external data set also revealed good
      performance (c index, 0.71; goodness-of-fit P = .25; sensitivity, 46%;
      specificity, 76%). CONCLUSION: A derived prediction model incorporating ancillary
      aortic findings detected on routine diagnostic CT images complements established 
      risk scores and may help to identify patients at high risk for CVD. Timely
      application of preventative measures may ultimately reduce the number or severity
      of CVD events.
CI  - (c) RSNA, 2010.
FAU - Gondrie, Martijn J A
AU  - Gondrie MJ
AD  - Julius Center for Health Sciences and Primary Care, University Medical Center
      Utrecht, Room Str 6.131, Universiteitsweg 100, PO Box 85500, 3508 GA Utrecht, the
      Netherlands. m.gondrie@umcutrecht.nl
FAU - Mali, Willem P T M
AU  - Mali WP
FAU - Jacobs, Peter C
AU  - Jacobs PC
FAU - Oen, Ay L
AU  - Oen AL
FAU - van der Graaf, Yolanda
AU  - van der Graaf Y
CN  - PROVIDI Study Group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100928
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
SB  - IM
CIN - Radiology. 2010 Nov;257(2):313-4. PMID: 20959544
MH  - Aorta, Thoracic/*diagnostic imaging
MH  - Aortic Diseases/*diagnostic imaging
MH  - Cardiovascular Diseases/*diagnostic imaging
MH  - Contrast Media
MH  - Female
MH  - Humans
MH  - Incidental Findings
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Proportional Hazards Models
MH  - Radiography, Thoracic
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2010/09/30 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/09/30 06:00
PHST- 2010/09/30 06:00 [entrez]
PHST- 2010/09/30 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - radiol.10100054 [pii]
AID - 10.1148/radiol.10100054 [doi]
PST - ppublish
SO  - Radiology. 2010 Nov;257(2):549-59. doi: 10.1148/radiol.10100054. Epub 2010 Sep
      28.


PMID- 20876389
OWN - NLM
STAT- MEDLINE
DCOM- 20110110
LR  - 20101118
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 257
IP  - 3
DP  - 2010 Dec
TI  - Neonatal cochlear function: measurement after exposure to acoustic noise during
      in utero MR imaging.
PG  - 802-9
LID - 10.1148/radiol.10092366 [doi]
AB  - PURPOSE: To establish whether fetal exposure to the operating noise of 1.5-T
      magnetic resonance (MR) imaging is associated with cochlear injury and subsequent
      hearing loss in neonates. MATERIALS AND METHODS: The study was performed with
      local research ethics committee approval and written informed parental consent.
      Neonatal hearing test results, including otoacoustic emission (OAE) data, were
      sought for all neonates delivered in Sheffield who had previously undergone in
      utero MR imaging between August 1999 and September 2007. The prevalence of
      hearing impairment in these neonates was determined, with corresponding 95%
      confidence intervals calculated by using the binomial exact method, and mean OAE 
      measurements were compared with anonymized local audiometric reference data by
      using the t test. RESULTS: One hundred three neonates who had undergone in utero 
      MR imaging were identified; 96 of them had completed hearing screening
      assessment. Thirty-four of these babies were admitted to the neonatal intensive
      care unit (NICU), and one of them had bilateral hearing impairment. The
      prevalence of hearing impairment was 1% (one of 96; 95% confidence interval:
      0.03%, 5.67%), which is in accordance with the prevalence expected, given the
      high proportion of babies in this study who had been in the NICU (ie, NICU
      graduates). In addition, for the well babies, there was no significant difference
      in mean OAE cochlear response compared with that for a reference data set of more
      than 16,000 OAE results. When NICU graduates were included in the comparison, a
      significant difference (P = .002) was found in one of four frequency bands used
      to analyze the cochlear response; however, this difference was small compared
      with the normal variation in OAE measurements. CONCLUSION: The findings in this
      study provide some evidence that exposure of the fetus to 1.5-T MR imaging during
      the second and third trimesters of pregnancy is not associated with an increased 
      risk of substantial neonatal hearing impairment.
CI  - (c) RSNA, 2010.
FAU - Reeves, Michael J
AU  - Reeves MJ
AD  - Academic Unit of Radiology, University of Sheffield, Royal Hallamshire Hospital, 
      Glossop Rd, C Floor, Sheffield S10 2JF, England. m.reeves@sheffield.ac.uk
FAU - Brandreth, Marian
AU  - Brandreth M
FAU - Whitby, Elspeth H
AU  - Whitby EH
FAU - Hart, Anthony R
AU  - Hart AR
FAU - Paley, Martyn N J
AU  - Paley MN
FAU - Griffiths, Paul D
AU  - Griffiths PD
FAU - Stevens, John C
AU  - Stevens JC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100927
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - *Acoustic Stimulation
MH  - Cochlea/*physiology
MH  - Female
MH  - Gestational Age
MH  - Hearing Disorders/*diagnosis/epidemiology/physiopathology
MH  - Humans
MH  - Infant, Newborn
MH  - Magnetic Resonance Imaging/*adverse effects
MH  - Male
MH  - Neonatal Screening/*methods
MH  - *Noise
MH  - Otoacoustic Emissions, Spontaneous
MH  - Pregnancy
MH  - Prevalence
MH  - Risk Factors
EDAT- 2010/09/30 06:00
MHDA- 2011/01/11 06:00
CRDT- 2010/09/30 06:00
PHST- 2010/09/30 06:00 [entrez]
PHST- 2010/09/30 06:00 [pubmed]
PHST- 2011/01/11 06:00 [medline]
AID - radiol.10092366 [pii]
AID - 10.1148/radiol.10092366 [doi]
PST - ppublish
SO  - Radiology. 2010 Dec;257(3):802-9. doi: 10.1148/radiol.10092366. Epub 2010 Sep 27.


PMID- 20876150
OWN - NLM
STAT- MEDLINE
DCOM- 20101005
LR  - 20181023
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 341
DP  - 2010 Sep 27
TI  - Ethicists express concern about influence of PR firm on flu experts.
PG  - c5183
LID - 10.1136/bmj.c5183 [doi]
LID - bmj.c5183 [pii]
FAU - Sweet, Melissa
AU  - Sweet M
LA  - eng
PT  - News
DEP - 20100927
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
RN  - 0 (Influenza Vaccines)
SB  - IM
MH  - Australia
MH  - *Bioethical Issues
MH  - Child
MH  - Drug Industry/*ethics
MH  - Electronic Mail
MH  - Government
MH  - Humans
MH  - *Influenza Vaccines/adverse effects
MH  - *Public Relations
EDAT- 2010/09/30 06:00
MHDA- 2010/10/06 06:00
CRDT- 2010/09/30 06:00
PHST- 2010/09/30 06:00 [entrez]
PHST- 2010/09/30 06:00 [pubmed]
PHST- 2010/10/06 06:00 [medline]
AID - 10.1136/bmj.c5183 [doi]
PST - epublish
SO  - BMJ. 2010 Sep 27;341:c5183. doi: 10.1136/bmj.c5183.


PMID- 20876079
OWN - NLM
STAT- MEDLINE
DCOM- 20110405
LR  - 20171116
IS  - 1468-3318 (Electronic)
IS  - 0964-4563 (Linking)
VI  - 19
IP  - 5
DP  - 2010 Oct
TI  - Ending appreciable tobacco use in a nation: using a sinking lid on supply.
PG  - 431-5
LID - 10.1136/tc.2010.036681 [doi]
AB  - We discuss some of the practical and ethical questions that may arise for a
      jurisdiction where a sinking lid endgame strategy for tobacco supply is
      implemented. Such a strategy would involve regular required reductions in the
      amount of tobacco released to the market for sale, sufficient to achieve the
      desired level of commercial sales by a target date. Tobacco manufacturers would
      periodically bid to the government for a residual quota. Prices would increase as
      supply reduced. The price level would be influenced by demand, which in turn
      would reflect the impact of other interventions to reduce demand and the changing
      normality of smoking. Higher priced tobacco could result in increased smuggling, 
      theft, illegal sales and short-to-medium-term aggravation of some social
      inequalities. We suggest that the strategy be introduced in conjunction with a
      range of complementary interventions that would help reduce demand, and thus help
      ensure that the possible adverse effects are minimised. These complementary
      interventions include: providing comprehensive best practice smoking cessation
      support, better information to smokers and the public, strengthened regulation of
      tobacco retailing and supply, further controlling the pack and product design,
      measures to restrict supplies that bypass the increases in product price,
      strengthened enforcement and combating industry attacks. General prerequisites
      for a sinking lid strategy include public support for the goal of a tobacco-free 
      society, and strong political leadership. The likely context for initial success 
      in jurisdictions includes geographical isolation and/or strong border controls,
      absence of significant tobacco production and/or manufacturing and low government
      corruption.
FAU - Thomson, George
AU  - Thomson G
AD  - University of Otago, Wellington, Box 7343, Wellington, New Zealand.
      george.thomson@otago.ac.nz
FAU - Wilson, Nick
AU  - Wilson N
FAU - Blakely, Tony
AU  - Blakely T
FAU - Edwards, Richard
AU  - Edwards R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tob Control
JT  - Tobacco control
JID - 9209612
SB  - IM
MH  - *Commerce
MH  - Costs and Cost Analysis
MH  - Crime
MH  - *Government
MH  - Health Promotion/*methods
MH  - Humans
MH  - *Public Policy
MH  - Smoking/*economics
MH  - Smoking Cessation/*economics/methods
MH  - Smoking Prevention
MH  - Tobacco Industry/*economics
EDAT- 2010/09/30 06:00
MHDA- 2011/04/06 06:00
CRDT- 2010/09/30 06:00
PHST- 2010/09/30 06:00 [entrez]
PHST- 2010/09/30 06:00 [pubmed]
PHST- 2011/04/06 06:00 [medline]
AID - 19/5/431 [pii]
AID - 10.1136/tc.2010.036681 [doi]
PST - ppublish
SO  - Tob Control. 2010 Oct;19(5):431-5. doi: 10.1136/tc.2010.036681.


PMID- 20876037
OWN - NLM
STAT- MEDLINE
DCOM- 20110322
LR  - 20211020
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Linking)
VI  - 119
IP  - 1
DP  - 2011 Jan
TI  - Sharing unexpected biomarker results with study participants.
PG  - 1-5
LID - 10.1289/ehp.1001988 [doi]
AB  - BACKGROUND: The Breast Cancer and the Environment Research Centers (BCERCs)
      include collaborators from basic sciences, epidemiology, and the community,
      conducting studies to investigate whether environmental exposures are associated 
      with the timing of puberty. A pilot study of a subset of the study participants
      assessed the feasibility of measuring selected biomarkers of exposure in blood
      and urine in girls 6-8 years of age. In the Greater Cincinnati study population, 
      we found an elevated serum concentration of perfluorooctanoate (PFOA) among > 90%
      of young girls living in a small community. OBJECTIVES: The research team
      deliberated whether and how to report the PFOA findings to our study families. We
      will address the issues considered in our decision, as well as the formats we
      used to present the findings. METHODS: The results were verified as we searched
      for potential sources of the elevated PFOA levels. As a research team, we
      grappled with issues regarding the reporting of unexpected results, derived from 
      unknown sources and with unknown clinical significance. Ultimately, we did decide
      to present these findings to the study families through a well-developed
      communication plan. DISCUSSION: Research team members came from a variety of
      experiences and backgrounds, which led to different interpretations about the
      clinical, ethical, and public health issues surrounding these findings. The
      ethical debates centered around the precautionary principle, the right to know,
      and do no harm. CONCLUSIONS: Given advances in environmental biomarker
      technologies and greater use of the transdisciplinary research model, a
      communication plan must be developed for those involved as study participants.
FAU - Hernick, Ann D
AU  - Hernick AD
AD  - Breast Cancer Alliance of Greater Cincinnati, Cincinnati, Ohio, USA.
      adhernick@yahoo.com
FAU - Brown, M Kathryn
AU  - Brown MK
FAU - Pinney, Susan M
AU  - Pinney SM
FAU - Biro, Frank M
AU  - Biro FM
FAU - Ball, Kathleen M
AU  - Ball KM
FAU - Bornschein, Robert L
AU  - Bornschein RL
LA  - eng
GR  - P30 ES006096/ES/NIEHS NIH HHS/United States
GR  - P30-ES006096/ES/NIEHS NIH HHS/United States
GR  - U01-ES/CA12770/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100929
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - 0 (Biomarkers)
RN  - 0 (Caprylates)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Flame Retardants)
RN  - 0 (Fluorocarbons)
RN  - 947VD76D3L (perfluorooctanoic acid)
SB  - IM
MH  - Biomarkers/blood/urine
MH  - Caprylates/*blood/urine
MH  - Child
MH  - Disclosure/*ethics/standards
MH  - Environmental Exposure/*statistics & numerical data
MH  - Environmental Monitoring/ethics
MH  - Environmental Pollutants/*blood/urine
MH  - Female
MH  - Flame Retardants/*metabolism
MH  - Fluorocarbons/*blood/urine
MH  - Humans
MH  - Research Subjects
PMC - PMC3018486
EDAT- 2010/09/30 06:00
MHDA- 2011/03/23 06:00
CRDT- 2010/09/30 06:00
PHST- 2010/01/22 00:00 [received]
PHST- 2010/09/02 00:00 [accepted]
PHST- 2010/09/30 06:00 [entrez]
PHST- 2010/09/30 06:00 [pubmed]
PHST- 2011/03/23 06:00 [medline]
AID - 10.1289/ehp.1001988 [doi]
PST - ppublish
SO  - Environ Health Perspect. 2011 Jan;119(1):1-5. doi: 10.1289/ehp.1001988. Epub 2010
      Sep 29.


PMID- 20875892
OWN - NLM
STAT- MEDLINE
DCOM- 20110119
LR  - 20161020
IS  - 1532-8473 (Electronic)
IS  - 1089-9472 (Linking)
VI  - 25
IP  - 5
DP  - 2010 Oct
TI  - Ethical and legal aspects part 2: plagiarism--"what is it and how do I avoid
      it?".
PG  - 327-30
LID - 10.1016/j.jopan.2010.08.002 [doi]
FAU - Smith, Neal Jr
AU  - Smith N Jr
AD  - Florida Hospital College of Health Sciences, Orlando, FL, USA.
FAU - Wren, Kathleen R
AU  - Wren KR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Perianesth Nurs
JT  - Journal of perianesthesia nursing : official journal of the American Society of
      PeriAnesthesia Nurses
JID - 9610507
CIN - J Perianesth Nurs. 2011 Feb;26(1):3. PMID: 21276541
CIN - J Perianesth Nurs. 2011 Feb;26(1):3. PMID: 21276542
MH  - Authorship/*standards
MH  - *Ethics, Nursing
MH  - Humans
MH  - Nursing Research/standards
MH  - *Plagiarism
MH  - Publishing/*ethics
EDAT- 2010/09/30 06:00
MHDA- 2011/01/20 06:00
CRDT- 2010/09/30 06:00
PHST- 2010/07/26 00:00 [received]
PHST- 2010/08/01 00:00 [accepted]
PHST- 2010/09/30 06:00 [entrez]
PHST- 2010/09/30 06:00 [pubmed]
PHST- 2011/01/20 06:00 [medline]
AID - S1089-9472(10)00330-8 [pii]
AID - 10.1016/j.jopan.2010.08.002 [doi]
PST - ppublish
SO  - J Perianesth Nurs. 2010 Oct;25(5):327-30. doi: 10.1016/j.jopan.2010.08.002.


PMID- 20875226
OWN - NLM
STAT- MEDLINE
DCOM- 20110823
LR  - 20110503
IS  - 1555-3892 (Electronic)
IS  - 0963-6897 (Linking)
VI  - 20
IP  - 3
DP  - 2011
TI  - Stem cell transplantation for lymphoma patients with HIV infection.
PG  - 351-70
LID - 10.3727/096368910X528076 [doi]
AB  - The advent of Highly Active Antiretroviral Therapy (HAART) has radically changed 
      incidence characteristics and prognosis of HIV-positive patients affected by
      lymphomas. At this time there is consensus in the literature that, in first line,
      HIV-positive patients should always be treated with curative intent
      preferentially following the same approach used in the HIV-negative counterpart. 
      On the contrary, an approach of salvage therapy in HIV-positive lymphomas is
      still a matter of debate given that for a wide range of relapsed or resistant
      HIV-negative Hodgkin's disease (HD) and non-Hodgkin lymphoma (NHL) patients,
      autologous peripheral or allogeneic stem cell transplantation are among the
      established options. In the pre-HAART era, therapeutic options derived from
      pioneering experiences gave only anecdotal success, either when transplantation
      was used to cure lymphomas or to improve HIV infection itself. Concerns relating 
      to the entity, quality, and kinetics of early and late immune reconstitutions and
      the possible worsening of underlying viroimmunological conditions were additional
      obstacles. Currently, around 100 relapsed or resistant HIV-positive lymphomas
      have been treated with an autologous peripheral stem cell transplantation (APSCT)
      in the HAART era. Published data compared favorably with any previous salvage
      attempt showing a percentage of complete remission ranging from 48% to 90%, and
      overall survival ranging from 36% to 85% at median follow-up approaching 3 years.
      However, experiences are still limited and have given somewhat confounding
      indications, especially concerning timing and patients' selection for APSCT and
      feasibility and outcome for allogeneic stem cell transplant. Moreover, little
      data exist on the kinetics of immunological reconstitution after APSCT or
      relevant to the outcome of HIV infection. The aim of this review is to discuss
      current knowledge of the role of allogeneic and autologous stem cell
      transplantation as a modality in the cure of HIV and hemopoietic cancer patients.
      Several topics dealing with practical aspects concerning the management of APSCT 
      in HIV-positive patients, including patient selection, timing of transplant,
      conditioning regimen, and relapse or nonrelapse mortality, are discussed. Data
      relating to the effects of mobilization and transplantation on virological
      parameters and pre- and posttransplant immune reconstitution are reviewed.
      Finally, in this review, we examine several ethical and legal issues relative to 
      banking infected or potentially infected peripheral blood stem cells and we
      describe our experience and strategies to protect positive and negative
      donors/recipients and the health of caretakers.
FAU - Michieli, Mariagrazia
AU  - Michieli M
AD  - Cell Therapy and High Dose Chemotherapy Unit, Centro di Riferimento Oncologico,
      CRO IRCCS, Via F. Gallini 2, Aviano, PN, Italy.
FAU - Mazzucato, Mario
AU  - Mazzucato M
FAU - Tirelli, Umberto
AU  - Tirelli U
FAU - De Paoli, Paolo
AU  - De Paoli P
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100927
PL  - United States
TA  - Cell Transplant
JT  - Cell transplantation
JID - 9208854
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - Anti-HIV Agents/therapeutic use
MH  - CD4-Positive T-Lymphocytes/immunology/metabolism
MH  - CD8-Positive T-Lymphocytes/immunology/metabolism
MH  - HIV Infections/complications/*drug therapy
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - Lymphoma/complications/*therapy
MH  - Lymphoma, Non-Hodgkin/complications/*therapy
MH  - Salvage Therapy
EDAT- 2010/09/30 06:00
MHDA- 2011/08/24 06:00
CRDT- 2010/09/30 06:00
PHST- 2010/09/30 06:00 [entrez]
PHST- 2010/09/30 06:00 [pubmed]
PHST- 2011/08/24 06:00 [medline]
AID - ct2282michieli [pii]
AID - 10.3727/096368910X528076 [doi]
PST - ppublish
SO  - Cell Transplant. 2011;20(3):351-70. doi: 10.3727/096368910X528076. Epub 2010 Sep 
      27.


PMID- 20875211
OWN - NLM
STAT- MEDLINE
DCOM- 20110214
LR  - 20101027
IS  - 1478-9523 (Electronic)
IS  - 1478-9515 (Linking)
VI  - 8
IP  - 4
DP  - 2010 Dec
TI  - Journey of struggle: kalothanasia and the hospice way of dying.
PG  - 461-8
LID - 10.1017/S1478951510000349 [doi]
AB  - The purpose of this article is to characterize the notion of a "good death" both 
      historically and conceptually, grounding the philosophy of the modern hospice
      movement. This concept encompasses elements originating in ancient societies,
      such as peasant societies, where death was prepared for and shared socially, with
      ethical and aesthetic elements originating from Ancient Greece. These Greek
      elements emerged from a "journey of struggle" and can be recognized in the
      current day as a journey to cope with illness. From this conceptualization
      emerged a category of "good death" (kalothanasia), adding to the expertise of
      advocates of the modern hospice movement, who seek to revive a process of dying
      that is socially ritualized. However, this is challenging in the setting of a
      medical practice that is constantly incorporating new technology, in accordance
      with its present bio-techno-scientific paradigm, and in a medical scenario that
      identifies itself with the continued and persistent use of new technologies.
FAU - Floriani, Ciroaugusto
AU  - Floriani C
AD  - Bioethics Council, Brazilian National Cancer Institute, Rio de Janeiro, Brazil.
      ciroafloriani@gmail.com
FAU - Schramm, Fermin Roland
AU  - Schramm FR
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Review
DEP - 20100928
PL  - England
TA  - Palliat Support Care
JT  - Palliative & supportive care
JID - 101232529
SB  - IM
MH  - Adaptation, Psychological
MH  - *Attitude to Death
MH  - History, Ancient
MH  - Hospice Care/*history/*psychology
MH  - Humans
MH  - Terminally Ill/*psychology
EDAT- 2010/09/30 06:00
MHDA- 2011/02/15 06:00
CRDT- 2010/09/30 06:00
PHST- 2010/09/30 06:00 [entrez]
PHST- 2010/09/30 06:00 [pubmed]
PHST- 2011/02/15 06:00 [medline]
AID - S1478951510000349 [pii]
AID - 10.1017/S1478951510000349 [doi]
PST - ppublish
SO  - Palliat Support Care. 2010 Dec;8(4):461-8. doi: 10.1017/S1478951510000349. Epub
      2010 Sep 28.


PMID- 20874711
OWN - NLM
STAT- MEDLINE
DCOM- 20110407
LR  - 20151119
IS  - 1651-2227 (Electronic)
IS  - 0803-5253 (Linking)
VI  - 100
IP  - 1
DP  - 2011 Jan
TI  - Babies born at the threshold of viability: attitudes of paediatric consultants
      and trainees in South East England.
PG  - 42-6
LID - 10.1111/j.1651-2227.2010.01975.x [doi]
AB  - AIM: To determine attitudes of paediatric consultants and trainees towards
      immediate care of babies born at 22-24 weeks gestation. METHODS: A questionnaire 
      was sent to one consultant and one trainee within each of 63 neonatal units in
      South East England. RESULTS: Response rate was 90% (111/123). At 22 weeks
      gestation, 51% of all respondents would not attend the delivery. At 23 weeks
      gestation, 63% of respondents would advise against resuscitation during antenatal
      counselling but 45% would resuscitate despite a parental request for comfort
      care. Forty-one percent of respondents would provide comfort care for a 23 week
      gestation baby born in poor condition. If required, 53% of respondents would use 
      chest compressions and/or adrenaline at birth of a 24 week gestation infant (38% 
      consultants, 54% trainees; p = 0.05). More experienced and older paediatricians
      were more likely to attend 22 week deliveries and be comfortable with parental
      requests for resuscitation. Fifty-four percent of units had written guidelines on
      care of these babies. Significantly more consultants (67%) than trainees (25%)
      correctly classified neonatal deaths. CONCLUSIONS: Paediatricians with greater
      experience and age demonstrated more shared decision-making with parents. Nearly 
      half of paediatricians would defy parental wishes at 23 weeks gestation, contrary
      to ethical recommendations (Nuffield Council on Bioethics,
      http://www.nuffieldbioethics.org).
CI  - (c) 2010 The Author(s)/Acta Paediatrica (c) 2010 Foundation Acta Paediatrica.
FAU - Duffy, D
AU  - Duffy D
AD  - Ashford and St Peter's NHS Trust, St Peter's Hospital, Chertsey, Surrey, UK.
      donovanduffy@doctors.org.uk
FAU - Reynolds, P
AU  - Reynolds P
LA  - eng
PT  - Journal Article
DEP - 20100927
PL  - Norway
TA  - Acta Paediatr
JT  - Acta paediatrica (Oslo, Norway : 1992)
JID - 9205968
SB  - IM
MH  - Age Factors
MH  - *Attitude of Health Personnel
MH  - Clinical Competence
MH  - *Dissent and Disputes
MH  - England
MH  - *Fetal Viability
MH  - Gestational Age
MH  - Health Care Surveys
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - *Pediatrics
MH  - Practice Guidelines as Topic
MH  - Practice Patterns, Physicians'/*statistics & numerical data
MH  - *Professional-Family Relations
MH  - Resuscitation Orders
MH  - Surveys and Questionnaires
MH  - Time Factors
EDAT- 2010/09/30 06:00
MHDA- 2011/04/08 06:00
CRDT- 2010/09/30 06:00
PHST- 2010/09/30 06:00 [entrez]
PHST- 2010/09/30 06:00 [pubmed]
PHST- 2011/04/08 06:00 [medline]
AID - 10.1111/j.1651-2227.2010.01975.x [doi]
PST - ppublish
SO  - Acta Paediatr. 2011 Jan;100(1):42-6. doi: 10.1111/j.1651-2227.2010.01975.x. Epub 
      2010 Sep 27.


PMID- 20874235
OWN - NLM
STAT- MEDLINE
DCOM- 20110204
LR  - 20101014
IS  - 1557-7740 (Electronic)
IS  - 1557-7740 (Linking)
VI  - 13
IP  - 10
DP  - 2010 Oct
TI  - The critical role of religion: caring for the dying patient from an Orthodox
      Jewish perspective.
PG  - 1267-71
LID - 10.1089/jpm.2010.0088 [doi]
AB  - BACKGROUND AND OBJECTIVE: Culturally competent medical care for the dying patient
      by families and health care professionals is a challenging task especially when
      religious values, practices, and beliefs influence treatment decisions for
      patients at the end of life. This article describes end-of-life guidelines for
      hospital health care professionals caring for Orthodox Jewish patients and their 
      families. Religious perspectives on advance directives, comfort care and pain
      control, nutrition and hydration, do not resuscitate/do not intubate (DNR/DNI),
      and extubation are often unfamiliar to the American medical community. DESIGN:
      The guidelines for the care of the dying Orthodox Jewish patient were mutually
      agreed upon by the authors, recognized authorities in medicine, ethics, and
      Jewish law, who presented their perspectives during a 1-day symposium and who
      participated in an active working-group session. CONCLUSIONS: Care of the
      religious patient close to death is enormously complex especially when balancing 
      religious obligations, the role of the rabbi, medical procedures, and personal
      preferences. These guidelines address from a religious perspective profound
      issues such as the definition of death, organ donation, and caring for the
      patient at life's end. The guidelines can be useful for any hospital that serves 
      an Orthodox Jewish population.
FAU - Loike, John
AU  - Loike J
AD  - Center for Bioethics, College of Physicians and Surgeons, Columbia University,
      New York, New York 10032, USA.
FAU - Gillick, Muriel
AU  - Gillick M
FAU - Mayer, Stephan
AU  - Mayer S
FAU - Prager, Kenneth
AU  - Prager K
FAU - Simon, Jeremy R
AU  - Simon JR
FAU - Steinberg, Avraham
AU  - Steinberg A
FAU - Tendler, Moshe D
AU  - Tendler MD
FAU - Willig, Mordechai
AU  - Willig M
FAU - Fischbach, Ruth L
AU  - Fischbach RL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Palliat Med
JT  - Journal of palliative medicine
JID - 9808462
SB  - IM
MH  - Advance Directives
MH  - Attitude to Death
MH  - Cultural Competency
MH  - Decision Making
MH  - Fluid Therapy
MH  - Humans
MH  - *Judaism
MH  - Nutritional Support
MH  - Pain/prevention & control
MH  - *Terminal Care
MH  - Tissue and Organ Procurement
EDAT- 2010/09/30 06:00
MHDA- 2011/02/05 06:00
CRDT- 2010/09/30 06:00
PHST- 2010/09/30 06:00 [entrez]
PHST- 2010/09/30 06:00 [pubmed]
PHST- 2011/02/05 06:00 [medline]
AID - 10.1089/jpm.2010.0088 [doi]
PST - ppublish
SO  - J Palliat Med. 2010 Oct;13(10):1267-71. doi: 10.1089/jpm.2010.0088.


PMID- 20874234
OWN - NLM
STAT- MEDLINE
DCOM- 20110204
LR  - 20181201
IS  - 1557-7740 (Electronic)
IS  - 1557-7740 (Linking)
VI  - 13
IP  - 10
DP  - 2010 Oct
TI  - The PEACE project review of clinical instruments for hospice and palliative care.
PG  - 1253-60
LID - 10.1089/jpm.2010.0194 [doi]
AB  - BACKGROUND: Hospice and palliative care organizations are expanding their use of 
      standardized instruments and other approaches to measure quality. We undertook a 
      systematic review and evaluation of published patient-level instruments for
      potential application in hospice and palliative care clinical quality
      measurement. METHODS: We searched prior reviews and computerized reference
      databases from 1990 through February 2007 for studies of instruments relevant to 
      physical, psychological, social, cultural, spiritual, or ethical aspects of
      palliative care, or measuring prognosis, function or continuity of care.
      Publications were selected for full review if they provided evidence of
      psychometric properties or practical application of an instrument tested in or
      appropriate for a hospice or palliative care population. Selected instruments
      were evaluated and scored for scientific soundness and potential application in
      clinical quality measurement. RESULTS: The search found 1427 publications, with
      229 selected for full manuscript review. Manuscripts provided information on 129 
      instruments which were evaluated using a structured scoring guide for
      psychometric properties. Thirty-nine instruments scoring near or above the 75th
      percentile were recommended. Most instruments covered multiple domains or focused
      on care for physical symptoms, psychological or social aspects of care. Few
      instruments were available to measure cultural aspects of care, structure and
      process of care, and continuity of care. CONCLUSION: Numerous patient-level
      instruments are available to measure physical, psychological and social aspects
      of palliative care with adequate evidence for scientific soundness and practical 
      clinical use for quality improvement and research. Other aspects of palliative
      care may benefit from further instrument development research.
FAU - Hanson, Laura C
AU  - Hanson LC
AD  - Division of Geriatric Medicine and Center on Aging and Health, Gillings School of
      Global Public Health University of North Carolina, Chapel Hill, North Carolina
      27599-7550, USA. lhanson@med.unc.edu
FAU - Scheunemann, Leslie P
AU  - Scheunemann LP
FAU - Zimmerman, Sheryl
AU  - Zimmerman S
FAU - Rokoske, Franziska S
AU  - Rokoske FS
FAU - Schenck, Anna P
AU  - Schenck AP
LA  - eng
GR  - HHSM-500-2006-NC003C/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PT  - Systematic Review
PL  - United States
TA  - J Palliat Med
JT  - Journal of palliative medicine
JID - 9808462
SB  - IM
MH  - Hospice Care/*standards
MH  - Humans
MH  - Palliative Care/*standards
MH  - Psychometrics/*methods
MH  - Quality Improvement
MH  - *Total Quality Management
EDAT- 2010/09/30 06:00
MHDA- 2011/02/05 06:00
CRDT- 2010/09/30 06:00
PHST- 2010/09/30 06:00 [entrez]
PHST- 2010/09/30 06:00 [pubmed]
PHST- 2011/02/05 06:00 [medline]
AID - 10.1089/jpm.2010.0194 [doi]
PST - ppublish
SO  - J Palliat Med. 2010 Oct;13(10):1253-60. doi: 10.1089/jpm.2010.0194.


PMID- 20874104
OWN - NLM
STAT- MEDLINE
DCOM- 20110907
LR  - 20110526
IS  - 1557-8534 (Electronic)
IS  - 1547-3287 (Linking)
VI  - 20
IP  - 6
DP  - 2011 Jun
TI  - Derivation and characterization of novel nonhuman primate embryonic stem cell
      lines from in vitro-fertilized baboon preimplantation embryos.
PG  - 1053-62
LID - 10.1089/scd.2010.0372 [doi]
AB  - The development of nonhuman primate (NHP) embryonic stem cell (ESC) models holds 
      great promise for cell-mediated treatment of debilitating diseases and to address
      numerous unanswered questions regarding the therapeutic efficacy of ESCs while
      supplanting ethical considerations involved with human studies. Here we report
      successful establishment and characterization of 3 novel baboon (Papio
      cynocephalus) ESC lines from the inner cell mass of intracytoplasmic sperm
      injection-derived blastocysts. Embryos were cultured in an improved baboon embryo
      in vitro culture protocol. The inner cell mass of blastocyst was laser-dissected 
      and plated on mouse embryonic fibroblast feeder cell monolayer in the NHP ESC
      culture medium. Three cell lines with characteristic ESC morphology have been
      cultured through an extended period (>14 months), with 2 male cell lines (UT-1
      and -2) and 1 female cell line (UT-3) displaying normal baboon karyotypes.
      Reverse transcription-polymerase chain reaction analysis confirmed that all 3
      lines express primate ESC pluripotency markers, including OCT-4, NANOG, SOX-2,
      TERT, TDGF, LEFTYA, and REX-1. All 3 lines demonstrated positive
      immunocytochemical staining for OCT-4, stage-specific embryonic antigen-3,
      stage-specific embryonic antigen-4, TRA-1-60, and TRA-1-81. Baboon ESCs injected 
      into NOD/SCID mice formed teratomas with all 3 germ layers. In addition, embryoid
      body-like spherical structures were derived and initial outgrowth was observed
      when embedded into extracellular matrix Matrigel. The ESC lines established in
      this NHP model have the potential to extend our knowledge in the fields of
      developmental biology, regenerative medicine, and future applications, including 
      preclinical safety assessment of in vivo stem cell therapy.
FAU - Chang, Tien-Cheng
AU  - Chang TC
AD  - Division of Reproductive Endocrinology and Infertility, Department of Obstetrics 
      and Gynecology, School of Medicine, University of Texas Health Science Center,
      San Antonio, Texas 78229, USA. changt3@uthscsa.edu
FAU - Liu, Ya-Guang
AU  - Liu YG
FAU - Eddy, Carlton A
AU  - Eddy CA
FAU - Jacoby, Ethan S
AU  - Jacoby ES
FAU - Binkley, Peter A
AU  - Binkley PA
FAU - Brzyski, Robert G
AU  - Brzyski RG
FAU - Schenken, Robert S
AU  - Schenken RS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101104
PL  - United States
TA  - Stem Cells Dev
JT  - Stem cells and development
JID - 101197107
SB  - IM
MH  - Animals
MH  - Blastocyst/*cytology/metabolism
MH  - Cell Aggregation/genetics
MH  - Cell Culture Techniques/*methods
MH  - Cell Differentiation/genetics
MH  - Cell Line
MH  - Dissection
MH  - Embryoid Bodies/cytology/metabolism
MH  - Embryonic Stem Cells/*cytology/metabolism
MH  - Female
MH  - *Fertilization in Vitro
MH  - Humans
MH  - Immunohistochemistry
MH  - Karyotyping
MH  - Male
MH  - Mice
MH  - Papio/*embryology
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Teratoma/pathology
EDAT- 2010/09/30 06:00
MHDA- 2011/09/08 06:00
CRDT- 2010/09/30 06:00
PHST- 2010/09/30 06:00 [entrez]
PHST- 2010/09/30 06:00 [pubmed]
PHST- 2011/09/08 06:00 [medline]
AID - 10.1089/scd.2010.0372 [doi]
PST - ppublish
SO  - Stem Cells Dev. 2011 Jun;20(6):1053-62. doi: 10.1089/scd.2010.0372. Epub 2010 Nov
      4.


PMID- 20874063
OWN - NLM
STAT- MEDLINE
DCOM- 20110208
LR  - 20100929
IS  - 1369-1627 (Electronic)
IS  - 0954-0261 (Linking)
VI  - 22
IP  - 4
DP  - 2010
TI  - Current clinical advances and future perspectives in the psychiatry/mental health
      field of Latin America.
PG  - 340-6
LID - 10.3109/09540261.2010.501167 [doi]
AB  - The history of Mental Health in Latin America is relatively young. It dates back 
      to the mid nineteenth century and widely developed during the twentieth century, 
      with formidable scientific, social, political, and ethical challenges. Latin
      American psychiatry has contributed in the fields of epidemiology, phenomenology,
      social psychiatry, psychiatric and epistemological research, and clinical
      genetics as well. More recent advances can also be seen in clinical psychotherapy
      and psychopharmacology. Now, there is a formal and informal recognition of
      various areas of expertise, such as children and adolescents, addictions, anxiety
      disorders, among others. However, we need to solve the health problems resulting 
      from mental illnesses as well as the disorders related to the social,
      environmental, political, and economic factors of a continent marked by the
      precariousness of underdevelopment, which have a high impact on population
      health. Therefore, considering and trying to minimize the impact of those
      factors, contributing to the destigmatization of mental illnesses and their
      consequences, together with the growing number of non-governmental organizations 
      (NGOs), human rights defenders, public figures, etc., and collaborating in
      building a society that guarantees the right to mental health and adequate
      treatment and rehabilitation are part of our present challenges in Latin America.
FAU - Cia, Alfredo H
AU  - Cia AH
AD  - Anxiety Clinic and Research Center, Buenos Aires, Argentina. alfredocia@gmail.com
FAU - Rojas, Rodrigo Cordoba
AU  - Rojas RC
FAU - Adad, Miguel Abib
AU  - Adad MA
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int Rev Psychiatry
JT  - International review of psychiatry (Abingdon, England)
JID - 8918131
SB  - IM
MH  - Age Factors
MH  - Humans
MH  - Latin America/epidemiology
MH  - Mental Disorders/ethnology/*psychology/*therapy
MH  - *Mental Health
MH  - Psychiatry/*trends
MH  - *Psychopharmacology/methods/trends
MH  - *Psychotherapy/methods/trends
MH  - Risk Factors
MH  - Social Environment
EDAT- 2010/09/30 06:00
MHDA- 2011/02/09 06:00
CRDT- 2010/09/30 06:00
PHST- 2010/09/30 06:00 [entrez]
PHST- 2010/09/30 06:00 [pubmed]
PHST- 2011/02/09 06:00 [medline]
AID - 10.3109/09540261.2010.501167 [doi]
PST - ppublish
SO  - Int Rev Psychiatry. 2010;22(4):340-6. doi: 10.3109/09540261.2010.501167.


PMID- 20874061
OWN - NLM
STAT- MEDLINE
DCOM- 20110208
LR  - 20100929
IS  - 1369-1627 (Electronic)
IS  - 0954-0261 (Linking)
VI  - 22
IP  - 4
DP  - 2010
TI  - Psychiatry and human rights in Latin America: ethical dilemmas and the future.
PG  - 325-9
LID - 10.3109/09540261.2010.500864 [doi]
AB  - This paper addresses the context in which ethical and human right issues as they 
      pertain to psychiatry are discussed in Latin America. Dependency and
      institutional instability are singled out as pervading characteristics
      influencing the analysis of issues and the design of mental health policies.
      According to the landmark 1990 Declaration of Caracas all countries in the region
      have progressed towards implementing measures designed to improve the condition
      of the populations regarding mental health care and research. Several principles 
      are now universally accepted and, while there is still room for improvement,
      provision of services and better contexts for scientific development make it
      possible to expect advances in the future.
FAU - Lolas, Fernando
AU  - Lolas F
AD  - University of Chile and Bioethics Program, Pan American Health Organization,
      Santiago, Chile. flolas@u.uchile.cl
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - England
TA  - Int Rev Psychiatry
JT  - International review of psychiatry (Abingdon, England)
JID - 8918131
SB  - IM
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Human Rights/history/psychology/*trends
MH  - Humans
MH  - Latin America/epidemiology
MH  - Mental Disorders/diagnosis/*ethnology/psychology
MH  - *Mental Health/history/statistics & numerical data
MH  - Psychiatry/history/*trends
MH  - Public Policy/history/*trends
EDAT- 2010/09/30 06:00
MHDA- 2011/02/09 06:00
CRDT- 2010/09/30 06:00
PHST- 2010/09/30 06:00 [entrez]
PHST- 2010/09/30 06:00 [pubmed]
PHST- 2011/02/09 06:00 [medline]
AID - 10.3109/09540261.2010.500864 [doi]
PST - ppublish
SO  - Int Rev Psychiatry. 2010;22(4):325-9. doi: 10.3109/09540261.2010.500864.


PMID- 20874040
OWN - NLM
STAT- MEDLINE
DCOM- 20110406
LR  - 20151119
IS  - 1875-9114 (Electronic)
IS  - 0277-0008 (Linking)
VI  - 30
IP  - 10
DP  - 2010 Oct
TI  - Systemic preexposure prophylaxis for human immunodeficiency virus infection.
PG  - 1021-30
LID - 10.1592/phco.30.10.1021 [doi]
AB  - Antiretroviral therapy has significantly improved the typical course of human
      immunodeficiency virus (HIV) infection in industrialized nations, and life
      expectancies associated with the infection have increased. However, infection
      rates have generally remained unchanged, with increases noted among certain
      subpopulations. The use of systemic preexposure prophylaxis for HIV infection has
      been proposed as an intervention to reduce the risk of disease transmission in
      at-risk individuals. The basis of this prophylaxis involves the orchestrated use 
      of antiretrovirals in uninfected individuals either continuously or just before
      high-risk situations, such as perinatal and occupational exposure to HIV, in
      order to reduce the likelihood of successful HIV infection. Data from the use of 
      antiretrovirals to prevent HIV infection in these scenarios support the concept
      of preexposure prophylaxis. Preliminary animal studies have focused on the use of
      antiretrovirals to prevent simian immunodeficiency virus infection in macaque
      monkeys, and these data have provided support for the potential efficacy of
      preexposure prophylaxis for HIV in humans. Limited human data are available,
      however, but studies are ongoing. Clinical trials have focused on the use of
      tenofovir disoproxil fumarate either alone or in combination with emtricitabine. 
      Tenofovir-emtricitabine-based regimens may be ideal, given the drugs'
      pharmacodynamic and pharmacokinetic properties. Some investigators have surveyed 
      at-risk individuals to assess their knowledge of preexposure prophylaxis and
      whether they used or intended to use this prevention strategy. Routine use of
      preexposure prophylaxis and even knowledge of its existence appear to be very
      limited. If efficacy is proved, use of preexposure prophylaxis faces several
      ethical issues. Ultimately, its success will depend on proof of
      cost-effectiveness. Until the many questions concerning optimal use of
      preexposure prophylaxis for HIV are answered, however, its use should be limited 
      to research-related clinical investigations.
FAU - Romanelli, Frank
AU  - Romanelli F
AD  - Colleges of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, USA.
      froma2@uky.edu
FAU - Murphy, Brian
AU  - Murphy B
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Pharmacotherapy
JT  - Pharmacotherapy
JID - 8111305
RN  - 0 (Anti-HIV Agents)
RN  - 0 (Antiviral Agents)
RN  - 0 (Organophosphonates)
RN  - 0 (Reverse Transcriptase Inhibitors)
RN  - 0W860991D6 (Deoxycytidine)
RN  - 99YXE507IL (Tenofovir)
RN  - G70B4ETF4S (Emtricitabine)
RN  - JAC85A2161 (Adenine)
SB  - IM
MH  - Adenine/analogs & derivatives/pharmacokinetics/pharmacology
MH  - Animals
MH  - Anti-HIV Agents/therapeutic use
MH  - Antiviral Agents/pharmacokinetics/pharmacology
MH  - Deoxycytidine/analogs & derivatives/pharmacokinetics/pharmacology
MH  - Emtricitabine
MH  - Female
MH  - HIV
MH  - HIV Infections/drug therapy/*prevention & control/*transmission
MH  - Humans
MH  - Infectious Disease Transmission, Vertical
MH  - Occupational Exposure/prevention & control
MH  - Organophosphonates/pharmacokinetics/pharmacology
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/drug therapy/*prevention & control
MH  - Reverse Transcriptase Inhibitors/pharmacokinetics/pharmacology
MH  - Risk Factors
MH  - Risk-Taking
MH  - Tenofovir
EDAT- 2010/09/30 06:00
MHDA- 2011/04/07 06:00
CRDT- 2010/09/30 06:00
PHST- 2010/09/30 06:00 [entrez]
PHST- 2010/09/30 06:00 [pubmed]
PHST- 2011/04/07 06:00 [medline]
AID - 10.1592/phco.30.10.1021 [doi]
AID - 10.1592/phco.30.10.1021 [pii]
PST - ppublish
SO  - Pharmacotherapy. 2010 Oct;30(10):1021-30. doi: 10.1592/phco.30.10.1021.


PMID- 20874015
OWN - NLM
STAT- MEDLINE
DCOM- 20110823
LR  - 20220316
IS  - 1466-187X (Electronic)
IS  - 0142-159X (Linking)
VI  - 33
IP  - 4
DP  - 2011
TI  - Twelve tips for ethical approval for research in health professions education.
PG  - 268-72
LID - 10.3109/0142159X.2010.507715 [doi]
AB  - BACKGROUND: A growing number of faculty are engaging in research in health
      professions education. Suggestions continue to be made in the literature for a
      clear and less onerous pathway for the ethical review of this work. AIM: We aim
      to provide advice about the ethics application process for those conducting
      research in health professions education. METHODS: We used critical reflection of
      our experiences as research ethics board (REB) members, applying for, reviewing
      and consulting about the ethics application process in both UK and Canadian
      health contexts in addition to evidence and advice that is available in the
      literature to inform the tips provided. RESULTS: Twelve tips are offered to help 
      faculty understand and navigate through the ethics application process.
      CONCLUSION: Health professionals have an important role to play in advancing the 
      field of health professions education, and despite issues identified with current
      review pathways, REB review is in place to ensure that this work is undertaken
      safely and ethically. We believe the tips offered in this article will help
      faculty identify, and devise plans to address, some ethical issues that are
      common in health professions education research.
FAU - Egan-Lee, Eileen
AU  - Egan-Lee E
AD  - Centre for Faculty Development, Faculty of Medicine University of Toronto at St. 
      Michael's Hospital, Canada.
FAU - Freitag, Sharon
AU  - Freitag S
FAU - Leblanc, Vicki
AU  - Leblanc V
FAU - Baker, Lindsay
AU  - Baker L
FAU - Reeves, Scott
AU  - Reeves S
LA  - eng
PT  - Journal Article
DEP - 20100927
PL  - England
TA  - Med Teach
JT  - Medical teacher
JID - 7909593
SB  - IM
MH  - Canada
MH  - Decision Making/*ethics
MH  - Ethics Committees
MH  - *Ethics, Research
MH  - Guidelines as Topic
MH  - Health Personnel/*education
MH  - Humans
MH  - United Kingdom
EDAT- 2010/09/30 06:00
MHDA- 2011/08/24 06:00
CRDT- 2010/09/30 06:00
PHST- 2010/09/30 06:00 [entrez]
PHST- 2010/09/30 06:00 [pubmed]
PHST- 2011/08/24 06:00 [medline]
AID - 10.3109/0142159X.2010.507715 [doi]
PST - ppublish
SO  - Med Teach. 2011;33(4):268-72. doi: 10.3109/0142159X.2010.507715. Epub 2010 Sep
      27.


PMID- 20873514
OWN - NLM
STAT- MEDLINE
DCOM- 20101102
LR  - 20191111
IS  - 0929-0273 (Print)
IS  - 0929-0273 (Linking)
VI  - 17
IP  - 4
DP  - 2010 Sep
TI  - Identifiability, genomics and U.K. data protection law.
PG  - 329-44
AB  - Analyses of individuals' genomes--their entire DNA sequence--have increased
      knowledge about the links between genetics and disease. Anticipated advances in
      'next generation' DNA-sequencing techniques will see the routine research use of 
      whole genomes, rather than distinct parts, within the next few years. The
      scientific benefits of genomic research are, however, accompanied by legal and
      ethical concerns. Despite the assumption that genetic research data can and will 
      be rendered anonymous, participants' identities can sometimes be elucidated,
      which could cause data protection legislation to apply. We undertake a timely
      reappraisal of these laws--particularly new penalties--and identifiability in
      genomic research.
FAU - Curren, Liam
AU  - Curren L
AD  - Centre for Health, Law and Emerging Technologies at Oxford (HeLEX), Department of
      Public Health and Primary Care, University of Oxford, Old Road Campus, Oxford OX3
      7LF, UK.
FAU - Boddington, Paula
AU  - Boddington P
FAU - Gowans, Heather
AU  - Gowans H
FAU - Hawkins, Naomi
AU  - Hawkins N
FAU - Kanellopoulou, Nadja
AU  - Kanellopoulou N
FAU - Kaye, Jane
AU  - Kaye J
FAU - Melham, Karen
AU  - Melham K
LA  - eng
GR  - WT081407/Z/06/Z/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Legal Case
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur J Health Law
JT  - European journal of health law
JID - 9431861
SB  - IM
MH  - Genetic Privacy/*legislation & jurisprudence
MH  - Genetic Research/ethics/legislation & jurisprudence
MH  - Genome, Human
MH  - Humans
MH  - United Kingdom
EDAT- 2010/09/30 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/09/30 06:00
PHST- 2010/09/30 06:00 [entrez]
PHST- 2010/09/30 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - 10.1163/157180910x516943 [doi]
PST - ppublish
SO  - Eur J Health Law. 2010 Sep;17(4):329-44. doi: 10.1163/157180910x516943.


PMID- 20873512
OWN - NLM
STAT- MEDLINE
DCOM- 20101025
LR  - 20191111
IS  - 1145-0762 (Print)
IS  - 1145-0762 (Linking)
VI  - 21
IP  - 2
DP  - 2010 Jun
TI  - [Bioethics: a drift from ethics towards an ethical drift?].
PG  - 79-93
FAU - Esquivel Sada, Daphne
AU  - Esquivel Sada D
AD  - Departement de Sociologie, Universite de Montreal.
      daphne.esquivel.sada@umontreal.ca
LA  - fre
PT  - Journal Article
TT  - La bioethique: d'un derive ethique vers un cas de derive?
PL  - France
TA  - J Int Bioethique
JT  - Journal international de bioethique = International journal of bioethics
JID - 9015754
SB  - IM
MH  - *Bioethical Issues
MH  - *Bioethics
MH  - Canada
MH  - *Ethics, Medical
MH  - Female
MH  - *Human Rights
MH  - Humans
MH  - Male
MH  - *Personhood
MH  - Politics
MH  - Pregnancy
MH  - United Kingdom
EDAT- 2010/09/30 06:00
MHDA- 2010/10/26 06:00
CRDT- 2010/09/30 06:00
PHST- 2010/09/30 06:00 [entrez]
PHST- 2010/09/30 06:00 [pubmed]
PHST- 2010/10/26 06:00 [medline]
AID - 10.3917/jib.212.0079 [doi]
PST - ppublish
SO  - J Int Bioethique. 2010 Jun;21(2):79-93. doi: 10.3917/jib.212.0079.


PMID- 20873335
OWN - NLM
STAT- MEDLINE
DCOM- 20100930
LR  - 20101020
IS  - 0023-7205 (Print)
IS  - 0023-7205 (Linking)
VI  - 107
IP  - 32-33
DP  - 2010 Aug 11-24
TI  - [Physicians' role in issuing "transportability" certificates: what do the medical
      ethics authorities say?].
PG  - 1856-7
FAU - Bodegard, Goran
AU  - Bodegard G
AD  - BUP-kliniken Nordvastra sjukvardsomradet, Stockholm. goran.bodegard@comhem.se
LA  - swe
PT  - Journal Article
TT  - Lakares medverkan vid utfardande av transportabilitetsintyg: Vad sager den
      medicinska professionens etiska auktoriteter?
PL  - Sweden
TA  - Lakartidningen
JT  - Lakartidningen
JID - 0027707
SB  - IM
CIN - Lakartidningen. 2010 Aug 25-31;107(34):1941; discussion 1941-2. PMID: 20960961
MH  - Child
MH  - *Child Behavior Disorders/diagnosis
MH  - Emigration and Immigration
MH  - *Ethics, Medical
MH  - Humans
MH  - Physician's Role
MH  - *Refugees/psychology
MH  - Sweden
MH  - Transportation of Patients/*ethics
EDAT- 2010/09/29 06:00
MHDA- 2010/10/01 06:00
CRDT- 2010/09/29 06:00
PHST- 2010/09/29 06:00 [entrez]
PHST- 2010/09/29 06:00 [pubmed]
PHST- 2010/10/01 06:00 [medline]
PST - ppublish
SO  - Lakartidningen. 2010 Aug 11-24;107(32-33):1856-7.


PMID- 20873089
OWN - NLM
STAT- MEDLINE
DCOM- 20101026
LR  - 20100928
IS  - 0125-2208 (Print)
IS  - 0125-2208 (Linking)
VI  - 93
IP  - 9
DP  - 2010 Sep
TI  - Assessment of medical ethics of fourth-year medical students.
PG  - 1115-8
AB  - From 2005 to 2008, the authors assessed the medical ethics of 779 medical
      students in the Department of Obstetrics and Gynecology at the Faculty of
      Medicine, Chulalongkorn University by using the Chula Method. This was conducted 
      through a written examination asking the students to express their opinions about
      ethical issues. Their answers were rated as either Satisfactory (S) or
      Unsatisfactory (U). It was found that 750 students (96.3%) earned S while 29
      students (3.7%) earned U. The results from this study can not be compared with
      the results from studies published in medical journals. Thus, knowledge about
      medical ethics is not complete even though it is intensively taught in medical
      schools and has been practiced for a long time. The authors would like to propose
      a new assessment of the medical ethics so that it can be systematically applied.
FAU - Phaosavasdi, Sukhit
AU  - Phaosavasdi S
AD  - Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn
      University, Bangkok, Thailand. sukhit.p@chula.ac.th
FAU - Taneepanichsakul, Surasak
AU  - Taneepanichsakul S
FAU - Witoonpanich, Pairoj
AU  - Witoonpanich P
FAU - Tannirandorn, Yuen
AU  - Tannirandorn Y
FAU - Pruksananonda, Kamthorn
AU  - Pruksananonda K
FAU - Uerpairojkit, Boonchai
AU  - Uerpairojkit B
FAU - Sittisomwong, Tul
AU  - Sittisomwong T
FAU - Phupong, Vorapong
AU  - Phupong V
FAU - Manchana, Tarinee
AU  - Manchana T
FAU - Nirutisart, Somchai
AU  - Nirutisart S
LA  - eng
PT  - Journal Article
PL  - Thailand
TA  - J Med Assoc Thai
JT  - Journal of the Medical Association of Thailand = Chotmaihet thangphaet
JID - 7507216
SB  - IM
MH  - Education, Medical, Undergraduate/*methods
MH  - Educational Measurement
MH  - Ethics, Medical/*education
MH  - Female
MH  - Gynecology/education
MH  - Humans
MH  - Male
MH  - Obstetrics/education
MH  - Schools, Medical
MH  - Students, Medical
MH  - Young Adult
EDAT- 2010/09/29 06:00
MHDA- 2010/10/27 06:00
CRDT- 2010/09/29 06:00
PHST- 2010/09/29 06:00 [entrez]
PHST- 2010/09/29 06:00 [pubmed]
PHST- 2010/10/27 06:00 [medline]
PST - ppublish
SO  - J Med Assoc Thai. 2010 Sep;93(9):1115-8.


PMID- 20872911
OWN - NLM
STAT- MEDLINE
DCOM- 20111007
LR  - 20131121
IS  - 1099-0801 (Electronic)
IS  - 0269-3879 (Linking)
VI  - 25
IP  - 7
DP  - 2011 Jul
TI  - Determination of ciprofloxacin in plasma by micro-liquid chromatography-mass
      spectrometry: an adapted method for neonates.
PG  - 827-32
LID - 10.1002/bmc.1523 [doi]
AB  - There are many limitations to conducting pharmacokinetic studies in neonates,
      both ethical and technical. Regarding technical aspects, the number and volume of
      samples are limited, and the analytical method to measure drug concentration
      should be both specific and highly sensitive. In the present report, an
      analytical method adapted to neonates was developed for the determination of
      ciprofloxacin plasma concentration. After a simple protein precipitation,
      analytes were separated on a micro-liquid chromatography and quantified by mass
      spectrometry, with D8-ciprofloxacin as internal standard. The calibration range
      was linear from 25 to 3000 ng/mL. Intra- and inter-day precision was less than
      2.4 and 4.1%, respectively. The acceptance criteria of accuracy (between 85 and
      115%) were met in all cases. A plasma volume of 150 microL was required to
      achieve the limit of quantification of 25 ng/mL. The method was successfully
      applied to routine monitoring of ciprofloxacin in pediatric patients and also
      used in preclinical studies. It will be used to determine the population
      pharmacokinetic parameters of ciprofloxacin in neonates.
CI  - Copyright (c) 2010 John Wiley & Sons, Ltd.
FAU - Grondin, Christel
AU  - Grondin C
AD  - Department of Pediatric Pharmacology and Pharmacogenetics, Hopital Robert Debre, 
      Paris, France.
FAU - Zhao, Wei
AU  - Zhao W
FAU - Fakhoury, May
AU  - Fakhoury M
FAU - Jacqz-Aigrain, Evelyne
AU  - Jacqz-Aigrain E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100927
PL  - England
TA  - Biomed Chromatogr
JT  - Biomedical chromatography : BMC
JID - 8610241
RN  - 5E8K9I0O4U (Ciprofloxacin)
SB  - IM
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Ciprofloxacin/*blood
MH  - Drug Monitoring/*methods
MH  - Drug Stability
MH  - Humans
MH  - Linear Models
MH  - Mass Spectrometry/*methods
MH  - Microtechnology
MH  - Neonatology/*methods
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
EDAT- 2010/09/28 06:00
MHDA- 2011/10/08 06:00
CRDT- 2010/09/28 06:00
PHST- 2010/06/02 00:00 [received]
PHST- 2010/08/11 00:00 [accepted]
PHST- 2010/09/28 06:00 [entrez]
PHST- 2010/09/28 06:00 [pubmed]
PHST- 2011/10/08 06:00 [medline]
AID - 10.1002/bmc.1523 [doi]
PST - ppublish
SO  - Biomed Chromatogr. 2011 Jul;25(7):827-32. doi: 10.1002/bmc.1523. Epub 2010 Sep
      27.


PMID- 20872605
OWN - NLM
STAT- MEDLINE
DCOM- 20110824
LR  - 20100927
IS  - 1534-8687 (Electronic)
IS  - 1520-3247 (Linking)
VI  - 2010
IP  - 129
DP  - 2010 Fall
TI  - The emotional foundations of high moral intelligence.
PG  - 77-94
LID - 10.1002/cd.276 [doi]
AB  - Moral intelligence is grounded in emotion and reason. Neuroscientific and
      clinical research illustrate how early life co-regulation with caregivers
      influences emotion, cognition, and moral character. Triune ethics theory
      (Narvaez, 2008) integrates neuroscientific, evolutionary, and developmental
      findings to explain differences in moral functioning, identifying security,
      engagement, and imagination ethics that can be dispositionally fostered by
      experience during sensitive periods, but also situationally triggered. Mature
      moral functioning relies on the integration of emotion, intuition, and reasoning,
      which come together in adaptive ethical expertise. Moral expertise can be
      cultivated in organizations using the integrative ethical education model.
CI  - (c) Wiley Periodicals, Inc.
FAU - Narvaez, Darcia
AU  - Narvaez D
AD  - Collaborative for Ethical Education, University of Notre Dame. dnarvaez@nd.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - New Dir Child Adolesc Dev
JT  - New directions for child and adolescent development
JID - 100886823
SB  - IM
MH  - Child
MH  - *Decision Making
MH  - *Emotions
MH  - Humans
MH  - *Intelligence
MH  - *Morals
MH  - *Psychological Theory
EDAT- 2010/09/28 06:00
MHDA- 2011/08/25 06:00
CRDT- 2010/09/28 06:00
PHST- 2010/09/28 06:00 [entrez]
PHST- 2010/09/28 06:00 [pubmed]
PHST- 2011/08/25 06:00 [medline]
AID - 10.1002/cd.276 [doi]
PST - ppublish
SO  - New Dir Child Adolesc Dev. 2010 Fall;2010(129):77-94. doi: 10.1002/cd.276.


PMID- 20872584
OWN - NLM
STAT- MEDLINE
DCOM- 20101015
LR  - 20211020
IS  - 1554-527X (Electronic)
IS  - 0736-0266 (Linking)
VI  - 28
IP  - 11
DP  - 2010 Nov
TI  - Effect of core suture technique and type on the gliding resistance during cyclic 
      motion following flexor tendon repair: a cadaveric study.
PG  - 1475-81
LID - 10.1002/jor.21177 [doi]
AB  - We investigated the effects of two suture techniques using three suture types in 
      a human model in vitro. We obtained 60 flexor digitorum profundus (FDP) tendons
      from cadavers and measured the gliding resistance during 1,000 cycles of
      simulated flexion-extension motion and load to failure of six groups: the
      modified Kessler (MK) repair using 3-0 coated, braided polyester (Ethibond,
      Ethicon, Somerville, NJ), 3-0 coated, braided polyester/monofilament polyethylene
      composite (FiberWire(R); Arthrex, Naples, FL), or 4-0 FiberWire; and the
      Massachusetts General Hospital (MGH) repair using 3-0 Ethibond, 3-0 FiberWire, or
      4-0 FiberWire. The 3-0 Ethibond MGH suture had significantly higher ultimate load
      to failure than the 3-0 or 4-0 FiberWire MK suture. The 3-0 and 4-0 FiberWire MGH
      sutures had significantly higher load to failure than the three MK groups. The
      gliding resistances of the three MGH groups were significantly higher than that
      of the three corresponding MK groups. The MGH repair had more gliding resistance 
      than an MK repair, even when comparing large diameter suture in the MK repair
      with smaller diameter suture in the MGH repair. In this study, suture technique
      was more important in predicting repair load to failure and gliding resistance
      than the nature or caliber of the suture material that was used.
CI  - (c) 2010 Orthopaedic Research Society.
FAU - Moriya, Tamami
AU  - Moriya T
AD  - Orthopedic Biomechanics Laboratory, Division of Orthopaedic Research, Mayo
      Clinic, 200 1st Street Southwest, Rochester, Minnesota, USA.
FAU - Zhao, Chunfeng
AU  - Zhao C
FAU - Yamashita, Toshihiko
AU  - Yamashita T
FAU - An, Kai-Nan
AU  - An KN
FAU - Amadio, Peter C
AU  - Amadio PC
LA  - eng
GR  - R01 AR044391/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Orthop Res
JT  - Journal of orthopaedic research : official publication of the Orthopaedic
      Research Society
JID - 8404726
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomechanical Phenomena
MH  - Cadaver
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Suture Techniques
MH  - *Sutures
MH  - Tendons/*surgery
MH  - Tensile Strength
PMC - PMC3906802
MID - NIHMS546563
EDAT- 2010/09/28 06:00
MHDA- 2010/10/16 06:00
CRDT- 2010/09/28 06:00
PHST- 2010/09/28 06:00 [entrez]
PHST- 2010/09/28 06:00 [pubmed]
PHST- 2010/10/16 06:00 [medline]
AID - 10.1002/jor.21177 [doi]
PST - ppublish
SO  - J Orthop Res. 2010 Nov;28(11):1475-81. doi: 10.1002/jor.21177.


PMID- 20872354
OWN - NLM
STAT- MEDLINE
DCOM- 20110209
LR  - 20171206
IS  - 1724-6008 (Electronic)
IS  - 0393-6155 (Linking)
VI  - 25
IP  - 3
DP  - 2010 Jul-Sep
TI  - Cervical cytology biobanking in Europe.
PG  - 117-25
AB  - A cervical cytology biobank (CCB) is an extension of current cytopathology
      laboratory practice consisting in the systematic storage of Pap smears or
      liquid-based cytology samples from women participating in cervical cancer
      screening with the explicit purpose to facilitate future scientific research and 
      quality audit of preventive services. A CCB should use an internationally agreed 
      uniform cytology terminology, be integrated in a national or regional screening
      registry, and be linked to other registries (histology, cancer, vaccination).
      Legal and ethical principles concerning personal integrity and data safety must
      be respected strictly. Biobank-based studies require approval of ethical review
      boards. A CCB is an almost inexhaustible resource for fundamental and applied
      biological research. In particular, it can contribute to answering questions on
      the natural history of HPV infection and HPV-induced lesions and cancers,
      screening effectiveness, exploration of new biomarkers, and surveillance of the
      short- and long-term effects of the introduction of HPV vaccination. To
      understand the limitations of CCB, more studies are needed on the quality of
      samples in relation to sample type, storage procedures, and duration of storage.
FAU - Arbyn, Marc
AU  - Arbyn M
AD  - Unit of Cancer Epidemiology, Scientific Institute of Public Health, Brussels,
      Belgium. marc.arbyn@wiv-isp.be
FAU - Van Veen, Evert-Ben
AU  - Van Veen EB
FAU - Andersson, Kristin
AU  - Andersson K
FAU - Bogers, Johannes
AU  - Bogers J
FAU - Boulet, Gaelle
AU  - Boulet G
FAU - Bergeron, Christine
AU  - Bergeron C
FAU - von Knebel-Doeberitz, Magnus
AU  - von Knebel-Doeberitz M
FAU - Dillner, Joakim
AU  - Dillner J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Int J Biol Markers
JT  - The International journal of biological markers
JID - 8712411
RN  - 0 (Papillomavirus Vaccines)
RN  - 63231-63-0 (RNA)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Alphapapillomavirus/isolation & purification/pathogenicity
MH  - *Biological Specimen Banks/ethics/legislation & jurisprudence/organization &
      administration/standards
MH  - Cervix Uteri/*cytology
MH  - DNA/isolation & purification
MH  - Europe/epidemiology
MH  - Female
MH  - Guidelines as Topic
MH  - Humans
MH  - Medical Record Linkage
MH  - Molecular Diagnostic Techniques/methods/standards
MH  - *Papanicolaou Test
MH  - Papillomavirus Infections/epidemiology/pathology/prevention & control
MH  - Papillomavirus Vaccines
MH  - RNA/isolation & purification
MH  - Registries
MH  - Specimen Handling/standards
MH  - Terminology as Topic
MH  - Uterine Cervical Neoplasms/epidemiology/pathology/prevention & control/virology
MH  - Uterine Cervicitis/pathology/virology
MH  - *Vaginal Smears
EDAT- 2010/09/28 06:00
MHDA- 2011/02/10 06:00
CRDT- 2010/09/28 06:00
PHST- 2010/09/28 06:00 [entrez]
PHST- 2010/09/28 06:00 [pubmed]
PHST- 2011/02/10 06:00 [medline]
AID - 3F9248AA-19CA-4884-B77E-F4390C54FCC3 [pii]
PST - ppublish
SO  - Int J Biol Markers. 2010 Jul-Sep;25(3):117-25.


PMID- 20872343
OWN - NLM
STAT- MEDLINE
DCOM- 20110429
LR  - 20180104
IS  - 1439-4421 (Electronic)
IS  - 0941-3790 (Linking)
VI  - 72
IP  - 11
DP  - 2010 Nov
TI  - [Memorandum registry for health services research].
PG  - 824-39
LID - 10.1055/s-0030-1263132 [doi]
AB  - On August 30, 2010, the German Network for Health Services Research [Deutsches
      Netzwerk Versorgungsforschung e. V. (DNVF e. V.)] approved the Memorandum III
      "Methods for Health Services Research", supported by their member societies
      mentioned as authors and published in this Journal [Gesundheitswesen 2010; 72:
      739-748]. Registries in Health Services Research vary in their aims and research 
      questions as well as in their designs, methods of data collection, and
      statistical analyses. This paper aims to provide both a methodological guideline 
      for developers to ensure a high quality of a planned registry and, to provide an 
      instrument for users of data from registries to assess their overall quality.
      First, the paper provides a definition of registries and presents an overview of 
      objectives in Health Services Research where registries can be useful. Second,
      several areas of methodological importance for the development of registries are 
      presented. This includes the different phases of a registry (i. e., conceptual
      and preliminary design, implementation), technical organisation of a registry,
      statistical analysis, reporting of results, data protection, and ethical/legal
      aspects. From these areas, several criteria are deduced to allow the assessment
      of the quality of a registry. Finally, a checklist to assess a registry's quality
      is presented.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Muller, D
AU  - Muller D
AD  - Institut fur Forschung in der Operativen Medizin, Universitat Witten-Herdecke.
FAU - Augustin, M
AU  - Augustin M
AD  - Deutsche Dermatologische Gesellschaft (DDG), Berufsverband der Deutschen
      Dermatologen, Universitatsklinikum Hamburg-Eppendorf
FAU - Banik, N
AU  - Banik N
AD  - GlaxoSmithKline GmbH & Co. KG, Munchen
FAU - Baumann, W
AU  - Baumann W
AD  - Wissenschaftliches Institut der Niedergelassenen Hamatologen und Onkologen GmbH
      (WINHO), Koln
FAU - Bestehorn, K
AU  - Bestehorn K
AD  - MSD SHARP & DOHME GMBH, Haar
FAU - Kieschke, J
AU  - Kieschke J
AD  - Berliner Herzinfarktregister, Innovationszentrum Technologien fur Gesundheit und 
      Ernahrung, TU Berlin
FAU - Lefering, R
AU  - Lefering R
AD  - Institut fur Forschung in der Operativen Medizin, Universitat Witten-Herdecke.
FAU - Maier, B
AU  - Maier B
AD  - Berliner Herzinfarktregister, Innovationszentrum Technologien fur Gesundheit und 
      Ernahrung, TU Berlin
FAU - Mathis, S
AU  - Mathis S
AD  - Ludwig Boltzmann Institut Health Technology Assessment, Wien
FAU - Rustenbach, S J
AU  - Rustenbach SJ
AD  - Niedersachsisches Landesgesundheitsamt, Hannover
FAU - Sauerland, S
AU  - Sauerland S
AD  - Institut fur Forschung in der Operativen Medizin, Universitat Witten-Herdecke.
FAU - Semler, S C
AU  - Semler SC
AD  - Telematikplattform fur Medizinische Forschungsnetze e. V. (TMF), Berlin
FAU - Stausberg, J
AU  - Stausberg J
AD  - Telematikplattform fur Medizinische Forschungsnetze e. V. (TMF), Berlin
AD  - Institut fur Medizinische Informationsverarbeitung, Biometrie und Epidemiologie, 
      Ludwig-Maximilians-Universitat, Munchen
FAU - Sturm, H
AU  - Sturm H
AD  - Sudwestdeutsches Tumorzentrum, Universitatsklinikum Tubingen; Schwenninger BKK,
      Schwenningen
FAU - Unger, C
AU  - Unger C
AD  - Epidemiologisches Krebsregister Niedersachsen, Hannover
AD  - Niedersachsisches Landesgesundheitsamt, Hannover
FAU - Neugebauer, E A M
AU  - Neugebauer EA
AD  - Institut fur Forschung in der Operativen Medizin, Universitat Witten-Herdecke.
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Memorandum Register fur die Versorgungsforschung.
DEP - 20100924
PL  - Germany
TA  - Gesundheitswesen
JT  - Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes
      (Germany))
JID - 9204210
SB  - IM
EIN - Gesundheitswesen. 2010 Nov;72(11):e65
MH  - Data Collection/statistics & numerical data
MH  - Germany
MH  - Health Services Research/*statistics & numerical data
MH  - Humans
MH  - Registries/*statistics & numerical data
MH  - Research Design/statistics & numerical data
EDAT- 2010/09/28 06:00
MHDA- 2011/04/30 06:00
CRDT- 2010/09/28 06:00
PHST- 2010/09/28 06:00 [entrez]
PHST- 2010/09/28 06:00 [pubmed]
PHST- 2011/04/30 06:00 [medline]
AID - 10.1055/s-0030-1263132 [doi]
PST - ppublish
SO  - Gesundheitswesen. 2010 Nov;72(11):824-39. doi: 10.1055/s-0030-1263132. Epub 2010 
      Sep 24.


PMID- 20870998
OWN - NLM
STAT- MEDLINE
DCOM- 20110103
LR  - 20100927
IS  - 1552-7409 (Electronic)
IS  - 0894-3184 (Linking)
VI  - 23
IP  - 4
DP  - 2010 Oct
TI  - Quality of worklife for nurses: an ethical perspective.
PG  - 287-9
LID - 10.1177/0894318410380259 [doi]
AB  - Much has been written regarding the global nurse shortage. Frequently, authors
      and speakers who represent the discipline of nursing raise the topic of
      contextual barriers and limitations experienced in the practice setting as
      potential for the de-valuing of human dignity in the worklife of nurses. Quality 
      of worklife issues arise and are reflected in observations of an ever-present
      difficulty with recruitment and retention of professional nurses in a multitude
      of global healthcare settings. This column is intended to begin a dialogue about 
      the valuing of human dignity for nurses and the quality-of-life issues that
      surface as described by nurses and healthcare recipients that dramatically
      influence the quality of nursing practice from the humanbecoming school of
      thought.
FAU - Milton, Constance L
AU  - Milton CL
AD  - California Baptist University, Riverside, CA 92504, USA.
      constancemilton@yahoo.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Nurs Sci Q
JT  - Nursing science quarterly
JID - 8805022
MH  - Humans
MH  - *Job Satisfaction
MH  - *Nursing
MH  - *Quality of Life
EDAT- 2010/09/28 06:00
MHDA- 2011/01/05 06:00
CRDT- 2010/09/28 06:00
PHST- 2010/09/28 06:00 [entrez]
PHST- 2010/09/28 06:00 [pubmed]
PHST- 2011/01/05 06:00 [medline]
AID - 23/4/287 [pii]
AID - 10.1177/0894318410380259 [doi]
PST - ppublish
SO  - Nurs Sci Q. 2010 Oct;23(4):287-9. doi: 10.1177/0894318410380259.


PMID- 20870668
OWN - NLM
STAT- MEDLINE
DCOM- 20110414
LR  - 20131121
IS  - 1940-5596 (Electronic)
IS  - 1089-2532 (Linking)
VI  - 14
IP  - 4
DP  - 2010 Dec
TI  - Effects of nondependent lung ventilation with continuous positive-pressure
      ventilation and high-frequency positive-pressure ventilation on right-ventricular
      function during 1-lung ventilation.
PG  - 291-300
LID - 10.1177/1089253210383585 [doi]
AB  - Background. The application of volume-controlled high frequency positive pressure
      ventilation (HFPPV) to the nondependent lung (NL) may have comparable effects to 
      continuous positive airway pressure (CPAP) on the right ventricular (RV)
      function, oxygenation, and surgical conditions during one lung ventilation (OLV) 
      for thoracotomy. Methods. After local ethics committee approval and informed
      consent, 75 patients scheduled for elective thoracotomy using OLV were randomly
      allocated to receive nondependent lung either CPAP 2 (CPAP2; n=25) or 5 (CPAP5;
      n=25) cm H2O pressure setting of the device or HFPPV using VT 3 mL-1, I: E ratio 
      <0.3 and R.R 60/min (HFPPV; n=25), followed 15 min of OLV. Intraoperative changes
      in RV ejection fraction (REF), end-diastolic volume (RVEDVI) and stroke work
      (RVSWI), stroke volume (SVI), oxygen delivery (DO2), and uptake (VO2) indices and
      shunt fraction (Qs: Qt) were recorded without any surgical manipulation of the
      lung. Results. The application of NL-HFPPV resulted in improved REF by 33%, SVI
      and DO2 (P < 0.01) and reduced RVEDVI, RVSWI, PVRI, oxygen uptake, and shunt
      fraction by 24.8% (P < 0.01) than in the NL-CPAP groups. Conclusion. We concluded
      that the use of NL-HFPPV is a feasible option and offers improved RV function and
      oxygenation during OLV for open thoracotomy.
FAU - El Tahan, Mohamed R
AU  - El Tahan MR
AD  - University of Dammam, Al Khubar, Saudi Arabia. mohamedrefaateltahan@yahoo.com
FAU - El Ghoneimy, Yasser
AU  - El Ghoneimy Y
FAU - Regal, Mohamed
AU  - Regal M
FAU - Deria, Afrah
AU  - Deria A
FAU - Al Ahmadey, Mona
AU  - Al Ahmadey M
FAU - El Emam, Hatem
AU  - El Emam H
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20100923
PL  - United States
TA  - Semin Cardiothorac Vasc Anesth
JT  - Seminars in cardiothoracic and vascular anesthesia
JID - 9807630
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Continuous Positive Airway Pressure/*methods
MH  - Female
MH  - High-Frequency Ventilation/*methods
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oxygen/metabolism
MH  - Respiration, Artificial/methods
MH  - Stroke Volume
MH  - Thoracotomy/*methods
MH  - *Ventricular Function, Right
MH  - Young Adult
EDAT- 2010/09/28 06:00
MHDA- 2011/04/16 06:00
CRDT- 2010/09/28 06:00
PHST- 2010/09/28 06:00 [entrez]
PHST- 2010/09/28 06:00 [pubmed]
PHST- 2011/04/16 06:00 [medline]
AID - 1089253210383585 [pii]
AID - 10.1177/1089253210383585 [doi]
PST - ppublish
SO  - Semin Cardiothorac Vasc Anesth. 2010 Dec;14(4):291-300. doi:
      10.1177/1089253210383585. Epub 2010 Sep 23.


PMID- 20870495
OWN - NLM
STAT- MEDLINE
DCOM- 20101029
LR  - 20100927
IS  - 1865-9217 (Print)
IS  - 1865-9217 (Linking)
VI  - 104
IP  - 5
DP  - 2010
TI  - [Prioritisation in health care: what does it mean?].
PG  - 418-24
LID - 10.1016/j.zefq.2010.06.022 [doi]
AB  - Coping with limited resources is one of the key challenges in patient care.
      Rationalisation reserves have already been exhausted in many areas. Particularly 
      in the health sector, the question needs to be clarified as to how the limited
      resources can be allocated fairly from both the ethical and legal point of view. 
      The medical community proposes that health care services be prioritised. In other
      words, priorities are defined in order to increase fair distribution in the
      health sector. In this context prioritisation does not mean the exclusion of
      medically necessary services, but grading the granting of services in accordance 
      with the principles of priority. The advantages of prioritisation lie primarily
      in the transparency of the procedure and in the chance of achieving consistent
      distribution decisions. Protection of the patient-physician relationship as a
      confidential relation would remain unaffected since prioritisation is not the
      same thing as rationing.
CI  - Copyright (c) 2010. Published by Elsevier GmbH.
FAU - Hoppe, Jorg-Dietrich
AU  - Hoppe JD
AD  - Bundesarztekammer, Berlin. praesident@baek.de
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Priorisierung in der medizinischen Versorgung--Was bedeutet das?
DEP - 20100620
PL  - Netherlands
TA  - Z Evid Fortbild Qual Gesundhwes
JT  - Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen
JID - 101477604
SB  - IM
MH  - Delivery of Health Care/standards
MH  - Demography
MH  - Germany
MH  - Health Care Rationing/methods/statistics & numerical data
MH  - Health Priorities/*organization & administration/standards/statistics & numerical
      data
MH  - Humans
EDAT- 2010/09/28 06:00
MHDA- 2010/10/30 06:00
CRDT- 2010/09/28 06:00
PHST- 2010/09/28 06:00 [entrez]
PHST- 2010/09/28 06:00 [pubmed]
PHST- 2010/10/30 06:00 [medline]
AID - S1865-9217(10)00158-3 [pii]
AID - 10.1016/j.zefq.2010.06.022 [doi]
PST - ppublish
SO  - Z Evid Fortbild Qual Gesundhwes. 2010;104(5):418-24. doi:
      10.1016/j.zefq.2010.06.022. Epub 2010 Jun 20.


PMID- 20870102
OWN - NLM
STAT- MEDLINE
DCOM- 20101014
LR  - 20150616
IS  - 1474-547X (Electronic)
IS  - 0140-6736 (Linking)
VI  - 376
IP  - 9746
DP  - 2010 Sep 25
TI  - Ethical challenges of innovative surgery: a response to the IDEAL
      recommendations.
PG  - 1113-5
LID - 10.1016/S0140-6736(10)61116-6 [doi]
FAU - Johnson, Jane
AU  - Johnson J
AD  - Department of Philosophy, Macquarie University, Sydney, Australia.
      jane.johnson@mq.edu.au
FAU - Rogers, Wendy
AU  - Rogers W
FAU - Lotz, Mianna
AU  - Lotz M
FAU - Townley, Cynthia
AU  - Townley C
FAU - Meyerson, Denise
AU  - Meyerson D
FAU - Tomossy, George
AU  - Tomossy G
LA  - eng
PT  - Journal Article
PL  - England
TA  - Lancet
JT  - Lancet (London, England)
JID - 2985213R
SB  - IM
MH  - Biomedical Technology/*ethics
MH  - *Conflict of Interest
MH  - Diffusion of Innovation
MH  - Ethics, Clinical
MH  - Ethics, Medical
MH  - Humans
MH  - Safety
MH  - Specialties, Surgical/*ethics
MH  - Surgical Procedures, Operative/adverse effects/*ethics/mortality
EDAT- 2010/09/28 06:00
MHDA- 2010/10/15 06:00
CRDT- 2010/09/28 06:00
PHST- 2010/09/28 06:00 [entrez]
PHST- 2010/09/28 06:00 [pubmed]
PHST- 2010/10/15 06:00 [medline]
AID - S0140-6736(10)61116-6 [pii]
AID - 10.1016/S0140-6736(10)61116-6 [doi]
PST - ppublish
SO  - Lancet. 2010 Sep 25;376(9746):1113-5. doi: 10.1016/S0140-6736(10)61116-6.


PMID- 20870101
OWN - NLM
STAT- MEDLINE
DCOM- 20101014
LR  - 20150616
IS  - 1474-547X (Electronic)
IS  - 0140-6736 (Linking)
VI  - 376
IP  - 9746
DP  - 2010 Sep 25
TI  - Success factors and ethical challenges of the Spanish Model of organ donation.
PG  - 1109-12
LID - 10.1016/S0140-6736(10)61342-6 [doi]
FAU - Rodriguez-Arias, David
AU  - Rodriguez-Arias D
AD  - Departamento de Historia del Derecho, Universidad de Salamanca, Salamanca, Spain.
      dra@usal.es
FAU - Wright, Linda
AU  - Wright L
FAU - Paredes, David
AU  - Paredes D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Lancet
JT  - Lancet (London, England)
JID - 2985213R
SB  - IM
MH  - Age Factors
MH  - *Brain Death/legislation & jurisprudence
MH  - Communication
MH  - Conflict of Interest
MH  - Death
MH  - European Union
MH  - Humans
MH  - Legislation, Medical
MH  - Living Donors/supply & distribution
MH  - *Presumed Consent/ethics/legislation & jurisprudence
MH  - Professional-Family Relations
MH  - Program Evaluation
MH  - Spain
MH  - Tissue Donors/*supply & distribution
MH  - Tissue and Organ Harvesting/*ethics
MH  - Tissue and Organ Procurement/*ethics/legislation & jurisprudence/*organization & 
      administration/trends
MH  - Trust
MH  - United States
EDAT- 2010/09/28 06:00
MHDA- 2010/10/15 06:00
CRDT- 2010/09/28 06:00
PHST- 2010/09/28 06:00 [entrez]
PHST- 2010/09/28 06:00 [pubmed]
PHST- 2010/10/15 06:00 [medline]
AID - S0140-6736(10)61342-6 [pii]
AID - 10.1016/S0140-6736(10)61342-6 [doi]
PST - ppublish
SO  - Lancet. 2010 Sep 25;376(9746):1109-12. doi: 10.1016/S0140-6736(10)61342-6.


PMID- 20870071
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20100927
IS  - 2162-5514 (Electronic)
IS  - 0074-7742 (Linking)
VI  - 92
DP  - 2010
TI  - To what extent do neurobiological sleep-waking processes support psychoanalysis?
PG  - 233-90
LID - 10.1016/S0074-7742(10)92012-6 [doi]
AB  - Sigmund Freud's thesis was that there is a censorship during waking that prevents
      memory of events, drives, wishes, and feelings from entering the consciousness
      because they would induce anxiety due to their emotional or ethical
      unacceptability. During dreaming, because the efficiency of censorship is
      decreased, latent thought contents can, after dream-work involving condensation
      and displacement, enter the dreamer's consciousness under the figurative form of 
      manifest content. The quasi-closed dogma of psychoanalytic theory as related to
      unconscious processes is beginning to find neurobiological confirmation during
      waking. Indeed, there are active processes that suppress (repress) unwanted
      memories from entering consciousness. In contrast, it is more difficult to find
      neurobiological evidence supporting an organized dream-work that would induce
      meaningful symbolic content, since dream mentation most often only shows
      psychotic-like activities.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Gottesmann, Claude
AU  - Gottesmann C
AD  - Departement de Biologie, Faculte des Sciences, Universite de Nice-Sophia
      Antipolis, Nice, France.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Int Rev Neurobiol
JT  - International review of neurobiology
JID - 0374740
SB  - IM
MH  - Dreams/*physiology/psychology
MH  - Humans
MH  - Psychoanalysis/*methods
MH  - Psychophysiology/*methods
MH  - Sleep/*physiology
MH  - Wakefulness/*physiology
EDAT- 2010/09/28 06:00
MHDA- 2011/06/29 06:00
CRDT- 2010/09/28 06:00
PHST- 2010/09/28 06:00 [entrez]
PHST- 2010/09/28 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
AID - S0074-7742(10)92012-6 [pii]
AID - 10.1016/S0074-7742(10)92012-6 [doi]
PST - ppublish
SO  - Int Rev Neurobiol. 2010;92:233-90. doi: 10.1016/S0074-7742(10)92012-6.


PMID- 20869626
OWN - NLM
STAT- MEDLINE
DCOM- 20110204
LR  - 20161222
IS  - 1556-3871 (Electronic)
IS  - 1547-5271 (Linking)
VI  - 7
IP  - 10
DP  - 2010 Oct
TI  - Interventional cardiology live case presentations regulatory considerations.
PG  - e1-3
LID - 10.1016/j.hrthm.2010.08.024 [doi]
AB  - Live case presentations are increasingly common at interventional cardiology
      conferences. Taking advantage of significant advances in communication
      technology, broadcasts of procedures can be viewed as an extension of traditional
      medical education targeted to large groups of practitioners. However, there are
      important ethical, commercial, and patient safety issues associated with live
      cases that deserve attention. Use of investigational devices in live case
      demonstrations is subject to review and approval by FDA's Center for Devices and 
      Radiological Health (CDRH), and the outcomes of patients participating in live
      cases are considered in the overall clinical study results. This article
      discusses CDRH's regulatory view of live case presentations with a focus on
      patient safety, clinical trial integrity, and concerns regarding improper medical
      device promotion.
CI  - Copyright (c) 2010. Published by Elsevier Inc.
FAU - Farb, Andrew
AU  - Farb A
FAU - Brown, Sheila A
AU  - Brown SA
FAU - Wolf, Deborah A
AU  - Wolf DA
FAU - Zuckerman, Bram
AU  - Zuckerman B
LA  - eng
PT  - Comment
PT  - Letter
PL  - United States
TA  - Heart Rhythm
JT  - Heart rhythm
JID - 101200317
SB  - IM
CON - Catheter Cardiovasc Interv. 2010 Oct 1;76(4):E126-9. PMID: 20862708
CON - J Am Coll Cardiol. 2010 Oct 5;56(15):1283-5. PMID: 20883943
MH  - Cardiology/*legislation & jurisprudence/standards
MH  - Clinical Trials as Topic/*legislation & jurisprudence
MH  - Device Approval/*legislation & jurisprudence
MH  - *Government Regulation
MH  - Humans
MH  - Informed Consent
MH  - *Therapies, Investigational
MH  - United States
MH  - United States Food and Drug Administration
EDAT- 2010/09/28 06:00
MHDA- 2011/02/05 06:00
CRDT- 2010/09/28 06:00
PHST- 2010/06/24 00:00 [received]
PHST- 2010/06/28 00:00 [accepted]
PHST- 2010/09/28 06:00 [entrez]
PHST- 2010/09/28 06:00 [pubmed]
PHST- 2011/02/05 06:00 [medline]
AID - S1547-5271(10)00893-3 [pii]
AID - 10.1016/j.hrthm.2010.08.024 [doi]
PST - ppublish
SO  - Heart Rhythm. 2010 Oct;7(10):e1-3. doi: 10.1016/j.hrthm.2010.08.024.


PMID- 20869554
OWN - NLM
STAT- MEDLINE
DCOM- 20101112
LR  - 20181201
IS  - 1097-6817 (Electronic)
IS  - 0194-5998 (Linking)
VI  - 143
IP  - 4
DP  - 2010 Oct
TI  - Surgical missions to developing countries: Ethical conflicts.
PG  - 476-9
LID - 10.1016/j.otohns.2010.05.011 [doi]
AB  - Each year scores of American physicians and nurses travel overseas, usually at
      their own expense, aiming to improve the lot of desperate patients in developing 
      countries. Our journals are filled with images of smiling children who have
      benefited from these gifts of care. Still, practicing medicine, and especially
      surgery, in a sporadic fashion in distant lands can lead to poor outcomes. It
      does little to improve public health or advance medical education. We address
      some of the ethical dilemmas intrinsic to international surgical missions and
      discuss how we might redirect our resources to provide better care to more
      people.
CI  - Copyright (c) 2010 American Academy of Otolaryngology-Head and Neck Surgery
      Foundation. Published by Mosby, Inc. All rights reserved.
FAU - Isaacson, Glenn
AU  - Isaacson G
AD  - Department of Otolaryngology-Head & Neck Surgery, Temple University School of
      Medicine, Philadelphia, PA, USA. glenn.isaacson@temple.edu
FAU - Drum, Elizabeth T
AU  - Drum ET
FAU - Cohen, Michael S
AU  - Cohen MS
LA  - eng
PT  - Journal Article
DEP - 20100816
PL  - England
TA  - Otolaryngol Head Neck Surg
JT  - Otolaryngology--head and neck surgery : official journal of American Academy of
      Otolaryngology-Head and Neck Surgery
JID - 8508176
SB  - IM
CIN - Otolaryngol Head Neck Surg. 2011 Feb;144(2):298; author reply 298-9. PMID:
      21493439
MH  - *Developing Countries
MH  - *Ethics
MH  - Ethiopia
MH  - Humans
MH  - Informed Consent/ethics
MH  - Medical Missions/economics/*ethics
MH  - Otorhinolaryngologic Surgical Procedures/*ethics
MH  - Patient Selection
MH  - United States
EDAT- 2010/09/28 06:00
MHDA- 2010/11/13 06:00
CRDT- 2010/09/28 06:00
PHST- 2010/05/03 00:00 [received]
PHST- 2010/05/12 00:00 [accepted]
PHST- 2010/09/28 06:00 [entrez]
PHST- 2010/09/28 06:00 [pubmed]
PHST- 2010/11/13 06:00 [medline]
AID - S0194-5998(10)00730-8 [pii]
AID - 10.1016/j.otohns.2010.05.011 [doi]
PST - ppublish
SO  - Otolaryngol Head Neck Surg. 2010 Oct;143(4):476-9. doi:
      10.1016/j.otohns.2010.05.011. Epub 2010 Aug 16.


PMID- 20869550
OWN - NLM
STAT- MEDLINE
DCOM- 20110114
LR  - 20211020
IS  - 1558-075X (Electronic)
IS  - 0146-0005 (Linking)
VI  - 34
IP  - 5
DP  - 2010 Oct
TI  - Toward an ethically responsible approach to vaginal birth after cesarean.
PG  - 337-44
LID - 10.1053/j.semperi.2010.05.007 [doi]
AB  - Determining approach to delivery after a previous cesarean is among the most
      contentious areas of obstetrics. We present a framework for ethically responsible
      guidelines and practice regarding vaginal birth after cesarean. We describe
      ethical complexities of 3 key issues that mark the debate: the cesarean delivery 
      rate, safety, and patient autonomy. We then describe a taxonomy of considerations
      that should inform a responsible framework for guideline development and
      highlight critical distinctions between types of guidelines that have been
      blurred in the past. We then forward 2 central claims. First, in otherwise
      uncomplicated birth after a single previous cesarean, both vaginal birth after
      cesarean and repeat cesarean should be regarded as reasonable options; women,
      rather than policymakers, providers, insurance carriers, or hospitals, should
      determine delivery approach. Second, in complicated cases, providers and
      policymakers should carefully calibrate the strength of evidence to ensure
      differential risk and cost are adequate to justify directive guidelines given
      important variations in values women bring to childbirth.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Lyerly, Anne Drapkin
AU  - Lyerly AD
AD  - Trent Center for Bioethics, Humanities and History of Medicine and Department of 
      Obstetrics and Gynecology, Duke University, Durham, NC, USA. LYERL003@mc.duke.edu
FAU - Little, Margaret Olivia
AU  - Little MO
LA  - eng
GR  - K01 HL072437/HL/NHLBI NIH HHS/United States
GR  - 5K01HL72437-05/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Semin Perinatol
JT  - Seminars in perinatology
JID - 7801132
SB  - IM
MH  - Cesarean Section/statistics & numerical data
MH  - Cesarean Section, Repeat/adverse effects
MH  - Female
MH  - Fetal Death/epidemiology
MH  - Humans
MH  - Maternal Mortality
MH  - Patient Preference
MH  - Practice Guidelines as Topic
MH  - Practice Patterns, Physicians'
MH  - Pregnancy
MH  - Risk Factors
MH  - Trial of Labor
MH  - Uterine Rupture
MH  - Vaginal Birth after Cesarean/adverse effects/*ethics
PMC - PMC2946940
MID - NIHMS231453
EDAT- 2010/09/28 06:00
MHDA- 2011/01/15 06:00
CRDT- 2010/09/28 06:00
PHST- 2010/09/28 06:00 [entrez]
PHST- 2010/09/28 06:00 [pubmed]
PHST- 2011/01/15 06:00 [medline]
AID - S0146-0005(10)00053-4 [pii]
AID - 10.1053/j.semperi.2010.05.007 [doi]
PST - ppublish
SO  - Semin Perinatol. 2010 Oct;34(5):337-44. doi: 10.1053/j.semperi.2010.05.007.


PMID- 20869277
OWN - NLM
STAT- MEDLINE
DCOM- 20110428
LR  - 20110125
IS  - 1873-4332 (Electronic)
IS  - 1083-3188 (Linking)
VI  - 24
IP  - 1
DP  - 2011 Feb
TI  - Determination of the motherly reactions to adolescents' experience of menarche.
      II.
PG  - 21-4
LID - 10.1016/j.jpag.2010.06.004 [doi]
AB  - OBJECTIVES: The study was conducted to identify mothers' reactions to adolescent 
      girls' experience of menarche. METHODS: This descriptive study was conducted in
      Obstetrics and Gynecology Clinic of the University Hospital in Eastern Anatolia
      in Erzurum, Turkey, between April and May 2009. The study comprised mothers of
      adolescent girls who had experienced menarche during the last 12 months. Two
      hundred and four mothers formed the sample for this study. However, 10 were
      removed from the study because their daughter did not inform them about their
      menarche experience and the mothers could not answer some questions. The study
      was thus conducted with 194 mothers. The data were collected via a questionnaire 
      prepared by the researchers and the data were evaluated using percentages.
      Approval for the research was obtained from the hospital and the ethics committee
      before commencement. The researchers provided the women with information about
      the survey. RESULTS: The average age of mothers was 41.37 +/- 6.5. A total of
      44.3% of mothers had achieved primary school educational level and 78.9% of
      mothers have lived in a nuclear family. Mothers' reactions to their daughters'
      experience of menarche largely consisted of providing them with information about
      what to do (72.2% of them gave information about bathing, 59.3% of them gave
      information about genital hygiene). Mother' positive attitudes were very low (18%
      of them kissed their daughters, 11.3% of them congratulated their daughters).
      There were 12.4% of mothers who were sad about their daughters' experience of
      menarche. CONCLUSIONS: It was determined in this study that the extent to which
      mothers showed reactions of happiness to their daughters' experience of menarche 
      is rather low, but the rate of mothers telling their daughters what to do in this
      period was quite high.
CI  - Copyright A(c) 2011 North American Society for Pediatric and Adolescent
      Gynecology. Published by Elsevier Inc. All rights reserved.
FAU - Ozdemir, Funda
AU  - Ozdemir F
AD  - Ankara University, Faculty of Health Sciences, Turkey.
FAU - Nazik, Evsen
AU  - Nazik E
FAU - Pasinlioglu, Turkan
AU  - Pasinlioglu T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100924
PL  - United States
TA  - J Pediatr Adolesc Gynecol
JT  - Journal of pediatric and adolescent gynecology
JID - 9610774
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Attitude
MH  - Emotions
MH  - Female
MH  - Humans
MH  - Menarche/*psychology
MH  - Mother-Child Relations
MH  - Mothers/*psychology
MH  - Turkey
EDAT- 2010/09/28 06:00
MHDA- 2011/04/29 06:00
CRDT- 2010/09/28 06:00
PHST- 2009/10/21 00:00 [received]
PHST- 2010/05/12 00:00 [revised]
PHST- 2010/06/25 00:00 [accepted]
PHST- 2010/09/28 06:00 [entrez]
PHST- 2010/09/28 06:00 [pubmed]
PHST- 2011/04/29 06:00 [medline]
AID - S1083-3188(10)00205-6 [pii]
AID - 10.1016/j.jpag.2010.06.004 [doi]
PST - ppublish
SO  - J Pediatr Adolesc Gynecol. 2011 Feb;24(1):21-4. doi: 10.1016/j.jpag.2010.06.004. 
      Epub 2010 Sep 24.


PMID- 20869028
OWN - NLM
STAT- MEDLINE
DCOM- 20110103
LR  - 20100927
IS  - 1532-8481 (Electronic)
IS  - 8755-7223 (Linking)
VI  - 26
IP  - 5
DP  - 2010 Sep-Oct
TI  - Nurse ethicist: innovative resource for nurses.
PG  - 287-92
LID - 10.1016/j.profnurs.2010.06.003 [doi]
AB  - Nurses are challenged with ethical problems on a daily basis, yet when they are
      students, nurses may have never had an opportunity to explore the complexities of
      how ethics will influence every facet of their nursing practice. This article
      describes how a large health care system, through collaboration between academic 
      and clinical partners, developed a nurse ethicist role to serve both the patient 
      care environment and students in academic programs. The nurse ethicist is charged
      with creating and sustaining programs in ethics and nursing ethics education with
      the goal of improving the capacity of nurses to manage the ethical issues
      inherent in the care of patients in a contemporary, technology-driven health care
      system. The Program in Nursing Ethics includes staff education, consultation and 
      support, and research. The addition to the faculty of a nurse ethicist who is
      active in clinical ethics consultation has strengthened the baccalaureate nursing
      curriculum by providing an instructor who creates and shares a clear vision for
      how ethics is central to quality nursing care. This article describes the central
      role of a nurse ethicist in promoting ethical nursing practice.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Wocial, Lucia D
AU  - Wocial LD
AD  - Indiana University School of Nursing, Indianapolis, IN, USA. lwocial@clarian.org
FAU - Bledsoe, Patricia
AU  - Bledsoe P
FAU - Helft, Paul R
AU  - Helft PR
FAU - Everett, Linda Q
AU  - Everett LQ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Prof Nurs
JT  - Journal of professional nursing : official journal of the American Association of
      Colleges of Nursing
JID - 8511298
SB  - IM
MH  - *Ethics, Nursing
MH  - *Nurses
EDAT- 2010/09/28 06:00
MHDA- 2011/01/05 06:00
CRDT- 2010/09/28 06:00
PHST- 2009/09/04 00:00 [received]
PHST- 2010/09/28 06:00 [entrez]
PHST- 2010/09/28 06:00 [pubmed]
PHST- 2011/01/05 06:00 [medline]
AID - S8755-7223(10)00062-1 [pii]
AID - 10.1016/j.profnurs.2010.06.003 [doi]
PST - ppublish
SO  - J Prof Nurs. 2010 Sep-Oct;26(5):287-92. doi: 10.1016/j.profnurs.2010.06.003.


PMID- 20869025
OWN - NLM
STAT- MEDLINE
DCOM- 20110103
LR  - 20220409
IS  - 1532-8481 (Electronic)
IS  - 8755-7223 (Linking)
VI  - 26
IP  - 5
DP  - 2010 Sep-Oct
TI  - The preceptorship experience: an examination of ethical and accountability
      issues.
PG  - 264-71
LID - 10.1016/j.profnurs.2009.12.008 [doi]
AB  - In this article, the authors examine ethical and accountability issues that
      emerged from a recent retrospective grounded theory study exploring the
      challenges for preceptors when working with nursing students whose clinical
      practice is unsafe. A primary goal of nursing education is to prepare safe and
      competent practitioners who can be accountable for their own actions (M. Smith,
      Y. McKoy, & J. Richardson, 2003). Within the context of preceptorship, both
      preceptors and faculty have an academic, legal, ethical, and professional
      responsibility not only to teach but also to evaluate students' clinical
      performance to ensure that as graduates of their programs they are competent to
      provide the public with safe nursing practice (P. Boley & K. Whitney, 2003; M.
      Smith, Y. McKoy, & J. Richardson, 2003). The findings of this study have
      implications for nurse educators and administrators in preparing and supporting
      both preceptors and students, especially in difficult or challenging
      teaching-learning situations.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Luhanga, Florence
AU  - Luhanga F
AD  - School of Nursing, Laurentian University, Sudbury, Ontario, Canada.
      fluhanga@laurentian.ca
FAU - Myrick, Florence
AU  - Myrick F
FAU - Yonge, Olive
AU  - Yonge O
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Prof Nurs
JT  - Journal of professional nursing : official journal of the American Association of
      Colleges of Nursing
JID - 8511298
SB  - IM
MH  - *Ethics
MH  - *Nursing
MH  - *Preceptorship
MH  - *Social Responsibility
EDAT- 2010/09/28 06:00
MHDA- 2011/01/05 06:00
CRDT- 2010/09/28 06:00
PHST- 2008/06/06 00:00 [received]
PHST- 2010/09/28 06:00 [entrez]
PHST- 2010/09/28 06:00 [pubmed]
PHST- 2011/01/05 06:00 [medline]
AID - S8755-7223(09)00187-2 [pii]
AID - 10.1016/j.profnurs.2009.12.008 [doi]
PST - ppublish
SO  - J Prof Nurs. 2010 Sep-Oct;26(5):264-71. doi: 10.1016/j.profnurs.2009.12.008.


PMID- 20868708
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20220310
IS  - 1872-678X (Electronic)
IS  - 0165-0270 (Linking)
VI  - 193
IP  - 2
DP  - 2010 Nov 30
TI  - Refinement of the use of food and fluid control as motivational tools for
      macaques used in behavioural neuroscience research: report of a Working Group of 
      the NC3Rs.
PG  - 167-88
LID - 10.1016/j.jneumeth.2010.09.003 [doi]
AB  - This report provides practical guidance on refinement of the use of food and
      fluid control as motivational tools for macaques used in behavioural neuroscience
      research. The guidance is based on consideration of the scientific literature
      and, where data are lacking, expert opinion and professional experience,
      including that of the members of a Working Group convened by the United Kingdom
      National Centre for the Replacement, Refinement and Reduction of Animals in
      Research (NC3Rs). The report should be useful to researchers, veterinarians and
      animal care staff responsible for the welfare of macaques used in food and fluid 
      control protocols, as well as those involved with designing, performing and
      analysing studies that use these protocols. It should also assist regulatory
      authorities and members of local ethical review processes or institutional animal
      care and use committees concerned with evaluating such protocols. The report
      provides a framework for refinement that can be tailored to meet local
      requirements. It also identifies data gaps and areas for future research and sets
      out the Working Group's recommendations on contemporary best practice.
CI  - Copyright (c) 2010 Elsevier B.V. All rights reserved.
FAU - Prescott, Mark J
AU  - Prescott MJ
AD  - National Centre for the Replacement, Refinement and Reduction of Animals in
      Research (NC3Rs), 20 Park Crescent, London, UK. mark.prescott@nc3rs.org.uk
FAU - Brown, Verity J
AU  - Brown VJ
FAU - Flecknell, Paul A
AU  - Flecknell PA
FAU - Gaffan, David
AU  - Gaffan D
FAU - Garrod, Kate
AU  - Garrod K
FAU - Lemon, Roger N
AU  - Lemon RN
FAU - Parker, Andrew J
AU  - Parker AJ
FAU - Ryder, Kathy
AU  - Ryder K
FAU - Schultz, Wolfram
AU  - Schultz W
FAU - Scott, Leah
AU  - Scott L
FAU - Watson, Jayne
AU  - Watson J
FAU - Whitfield, Lucy
AU  - Whitfield L
LA  - eng
GR  - 095495/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
DEP - 20100922
PL  - Netherlands
TA  - J Neurosci Methods
JT  - Journal of neuroscience methods
JID - 7905558
SB  - IM
CIN - J Neurosci Methods. 2012 Feb 15;204(1):202-5; discussion 206-13. PMID: 21459109
MH  - Animal Husbandry/ethics/methods/standards
MH  - Animal Welfare/ethics/standards
MH  - Animals
MH  - Behavior, Animal/*physiology
MH  - *Behavioral Research/ethics/methods/standards
MH  - Food
MH  - Guidelines as Topic
MH  - *Macaca
MH  - Motivation/*physiology
MH  - *Neurosciences
MH  - United Kingdom
EDAT- 2010/09/28 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/09/28 06:00
PHST- 2006/12/04 00:00 [received]
PHST- 2010/09/09 00:00 [revised]
PHST- 2010/09/15 00:00 [accepted]
PHST- 2010/09/28 06:00 [entrez]
PHST- 2010/09/28 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - S0165-0270(10)00515-7 [pii]
AID - 10.1016/j.jneumeth.2010.09.003 [doi]
PST - ppublish
SO  - J Neurosci Methods. 2010 Nov 30;193(2):167-88. doi:
      10.1016/j.jneumeth.2010.09.003. Epub 2010 Sep 22.


PMID- 20868531
OWN - NLM
STAT- MEDLINE
DCOM- 20110524
LR  - 20211020
IS  - 1471-2261 (Electronic)
IS  - 1471-2261 (Linking)
VI  - 10
DP  - 2010 Sep 27
TI  - Efficacy of a brief multifactorial adherence-based intervention on reducing the
      blood pressure of patients with poor adherence: protocol for a randomized
      clinical trial.
PG  - 44
LID - 10.1186/1471-2261-10-44 [doi]
AB  - BACKGROUND: Lowering of blood pressure by antihypertensive drugs reduces the
      risks of cardiovascular events, stroke, and total mortality. However, poor
      adherence to antihypertensive medications reduces their effectiveness and
      increases the risk of adverse events. In terms of relative risk reduction, an
      improvement in medication adherence could be as effective as the development of a
      new drug. METHODS/DESIGN: The proposed randomized controlled trial will include
      patients with a low adherence to medication and uncontrolled blood pressure. The 
      intervention group will receive a multifactorial intervention during the first,
      third, and ninth months, to improve adherence. This intervention will include
      motivational interviews, pill reminders, family support, blood pressure
      self-recording, and simplification of the dosing regimen. MEASUREMENT: The
      primary outcome is systolic blood pressure. The secondary outcomes are diastolic 
      blood pressure, proportion of patients with adequately controlled blood pressure,
      and total cost. DISCUSSION: The trial will evaluate the impact of a
      multifactorial adherence intervention in routine clinical practice. Ethical
      approval was given by the Ethical Committee on Human Research of Balearic
      islands, Spain (approval number IB 969/08 PI).
FAU - Leiva, Alfonso
AU  - Leiva A
AD  - Primary Care Research Unit of Mallorca, Baleares Health services-IbSalut, CAIBER,
      Mallorca, Spain. aleiva@ibsalut.caib.es
FAU - Fajo, Marta
AU  - Fajo M
FAU - Escriche, Luis
AU  - Escriche L
FAU - Audera, Francisco J
AU  - Audera FJ
FAU - Lopez, Sara
AU  - Lopez S
FAU - Martin, Ma Carmen
AU  - Martin MC
FAU - Gonzalez, Rosa
AU  - Gonzalez R
FAU - Tamborero, Gaspar
AU  - Tamborero G
FAU - Garcia, Elena M
AU  - Garcia EM
FAU - Duro, Rosa
AU  - Duro R
FAU - Orueta, Ramon
AU  - Orueta R
FAU - Serra, Francisca
AU  - Serra F
FAU - D'agosto P, Pilar
AU  - D'agosto P P
FAU - Miralles, Jeronima
AU  - Miralles J
FAU - Lorente, Patricia
AU  - Lorente P
FAU - Llobera, Joan
AU  - Llobera J
FAU - Iglesias, Ana Aurelia
AU  - Iglesias AA
FAU - Fernandez, Ruth
AU  - Fernandez R
FAU - Colom, Maria M
AU  - Colom MM
FAU - Buades, Aina M
AU  - Buades AM
FAU - Moreno, Lucia
AU  - Moreno L
FAU - Vidal, Clara
AU  - Vidal C
CN  - ADHERENCE group
LA  - eng
SI  - ISRCTN/ISRCTN21229328
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20100927
PL  - England
TA  - BMC Cardiovasc Disord
JT  - BMC cardiovascular disorders
JID - 100968539
RN  - 0 (Antihypertensive Agents)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Antihypertensive Agents/economics/*therapeutic use
MH  - Blood Pressure Determination
MH  - Costs and Cost Analysis
MH  - Female
MH  - Humans
MH  - Hypertension/*drug therapy/economics/physiopathology/psychology
MH  - Interview, Psychological
MH  - Male
MH  - *Medication Adherence/psychology/statistics & numerical data
MH  - Middle Aged
MH  - *Motivation
MH  - Research Design
MH  - Risk
MH  - Stroke/prevention & control
MH  - Treatment Outcome
PMC - PMC2955598
IR  - Viamonte EM
FIR - Viamonte, Elisa Miro
IR  - Sanchez Bueno V
FIR - Sanchez Bueno, Victoria
IR  - Tugores CA
FIR - Tugores, Catalina Andreu
IR  - Gomez-Calcerrada RM
FIR - Gomez-Calcerrada, Rosa Maria
IR  - Martinez Malabi MD
FIR - Martinez Malabi, Ma Dolores
IR  - Ortiz Vazquez MA
FIR - Ortiz Vazquez, Ma Amor
IR  - Ramos Gonzalez P
FIR - Ramos Gonzalez, Pedro
IR  - Noriega de la Parte MR
FIR - Noriega de la Parte, Ma Rosa
IR  - Madiedo Acosta MV
FIR - Madiedo Acosta, Ma Victoria
IR  - Ibanez Salas MA
FIR - Ibanez Salas, Ma Amparo
IR  - Rosello Sureda M
FIR - Rosello Sureda, Maria
IR  - Pascual Limones C
FIR - Pascual Limones, Catalina
IR  - Hermosa Munana C
FIR - Hermosa Munana, Cristina
IR  - Morera Espinosa MJ
FIR - Morera Espinosa, Maria Jesus
IR  - Biern Hernandez L
FIR - Biern Hernandez, Lourdes
IR  - Terron Rodriguez ME
FIR - Terron Rodriguez, Maria Elena
IR  - Perello Ripoll MA
FIR - Perello Ripoll, Maria Antonia
IR  - Munoz J
FIR - Munoz, Juana
IR  - Salas Ochagavia F
FIR - Salas Ochagavia, Francisca
IR  - Pocovi Subirana A
FIR - Pocovi Subirana, Antonia
EDAT- 2010/09/28 06:00
MHDA- 2011/05/25 06:00
CRDT- 2010/09/28 06:00
PHST- 2010/09/07 00:00 [received]
PHST- 2010/09/27 00:00 [accepted]
PHST- 2010/09/28 06:00 [entrez]
PHST- 2010/09/28 06:00 [pubmed]
PHST- 2011/05/25 06:00 [medline]
AID - 1471-2261-10-44 [pii]
AID - 10.1186/1471-2261-10-44 [doi]
PST - epublish
SO  - BMC Cardiovasc Disord. 2010 Sep 27;10:44. doi: 10.1186/1471-2261-10-44.


PMID- 20866024
OWN - NLM
STAT- MEDLINE
DCOM- 20101020
LR  - 20161125
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 21
IP  - 2
DP  - 2010 Summer
TI  - Legal briefing: conscience clauses and conscientious refusal.
PG  - 163-76
AB  - This issue's "Legal Briefing" column covers legal developments pertaining to
      conscience clauses and conscientious refusal. Not only has this topic been the
      subject of recent articles in this journal, but it has also been the subject of
      numerous public and professional discussions. Over the past several months,
      conscientious refusal disputes have had an unusually high profile not only in
      courthouses, but also in legislative and regulatory halls across the United
      States. Healthcare providers' own moral beliefs have been obstructing and are
      expected to increasingly obstruct patients' access to medical services. For
      example, some providers, on ethical or moral grounds, have denied: (1)
      sterilization procedures to pregnant patients, (2) pain medications in
      end-of-life situations, and (3) information about emergency contraception to rape
      victims. On the other hand, many healthcare providers have been forced to provide
      medical treatment that is inconsistent with their moral beliefs. There are two
      fundamental types of conscientious objection laws. First, there are laws that
      permit healthcare workers to refuse providing - on ethical, moral, or religious
      grounds healthcare services that they might otherwise have a legal or
      employer-mandated obligation to provide. Second, there are laws directed at
      forcing healthcare workers to provide services to which they might have ethical, 
      moral, or religious objections. Both types of laws are rarely comprehensive, but 
      instead target: (1) certain types of healthcare providers, (2) specific
      categories of healthcare services, (3) specific patient circumstances, and (4)
      certain conditions under which a right or obligation is triggered. For the sake
      of clarity, I have grouped recent legal developments concerning conscientious
      refusal into eight categories: 1. Abortion: right to refuse 2. Abortion: duty to 
      provide 3. Contraception: right to refuse 4. Contraception: duty to provide 5.
      Sterilization: right to refuse 6. Fertility, HIV, vaccines, counseling 7.
      End-of-life measures: right to refuse 8. Comprehensive laws: right to refuse.
FAU - Pope, Thaddeus Mason
AU  - Pope TM
AD  - Health Law Institute, Widener University School of Law, Wilmington, Delaware,
      USA. tmpope@widener.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
MH  - Abortion, Therapeutic/ethics/*legislation & jurisprudence
MH  - *Conscience
MH  - *Contraception/ethics
MH  - Delivery of Health Care/ethics/*legislation & jurisprudence/standards
MH  - Europe
MH  - Female
MH  - France
MH  - Human Rights
MH  - Humans
MH  - Internationality
MH  - Moral Obligations
MH  - Pharmacies/*legislation & jurisprudence
MH  - Pregnancy
MH  - Refusal to Treat/ethics/*legislation & jurisprudence
MH  - Sterilization, Reproductive/ethics/*legislation & jurisprudence
MH  - United Kingdom
MH  - United States
EDAT- 2010/09/28 06:00
MHDA- 2010/10/21 06:00
CRDT- 2010/09/28 06:00
PHST- 2010/09/28 06:00 [entrez]
PHST- 2010/09/28 06:00 [pubmed]
PHST- 2010/10/21 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2010 Summer;21(2):163-76.


PMID- 20866022
OWN - NLM
STAT- MEDLINE
DCOM- 20101020
LR  - 20131121
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 21
IP  - 2
DP  - 2010 Summer
TI  - In addition to benefits and harms: the relevance of the political.
PG  - 155-8
AB  - When working with parents of deaf children, clinicians and educators should
      explicitly add political-justice considerations to benefit-harm considerations in
      their ethical analyses of available interventions to prevent or reverse
      children's hearing impairments.
FAU - Russell, Barbara
AU  - Russell B
AD  - Centre for Addiction and Mental Health, University of Toronto's Joint Centre for 
      Bioethics in Toronto, Ontario. barbara_russell@camh.net
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
CON - J Clin Ethics. 2010 Summer;21(2):143-54. PMID: 20866021
MH  - Child, Preschool
MH  - Cochlear Implants
MH  - *Deafness/psychology/rehabilitation/surgery
MH  - Humans
MH  - Infant
MH  - *Parent-Child Relations
MH  - Parenting/psychology
MH  - Parents/psychology
MH  - *Persons With Hearing Impairments/psychology/rehabilitation
MH  - *Politics
EDAT- 2010/09/28 06:00
MHDA- 2010/10/21 06:00
CRDT- 2010/09/28 06:00
PHST- 2010/09/28 06:00 [entrez]
PHST- 2010/09/28 06:00 [pubmed]
PHST- 2010/10/21 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2010 Summer;21(2):155-8.


PMID- 20866018
OWN - NLM
STAT- MEDLINE
DCOM- 20101020
LR  - 20100927
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 21
IP  - 2
DP  - 2010 Summer
TI  - Conflicts of interest in deep brain stimulation research and the ethics of
      transparency.
PG  - 125-32
AB  - In this article we will draw on experiences from our own research on deep brain
      stimulation of the central thalamus in the minimally conscious state. We describe
      ethical challenges faced in clinical research involving medical devices and offer
      several cautionary notes about its funding and the interplay of market forces and
      scientific inquiry and suggest some reforms.
FAU - Fins, Joseph J
AU  - Fins JJ
AD  - Division of Medical Ethics, Weill Medical College of Cornell University, Ithaca, 
      NewYork, USA. jjfins@med.cornell.edu
FAU - Schiff, Nicholas D
AU  - Schiff ND
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
MH  - Biomedical Research/ethics
MH  - *Conflict of Interest
MH  - Deep Brain Stimulation/economics/*ethics/*instrumentation
MH  - Equipment and Supplies/*economics/ethics
MH  - Ethics, Research
MH  - Fellowships and Scholarships/ethics
MH  - Humans
MH  - Industry/ethics
MH  - *Intellectual Property
MH  - Neurosurgery/*ethics
MH  - Neurosurgical Procedures/ethics
MH  - Research Personnel/*ethics
MH  - Research Support as Topic/*ethics
MH  - United States
EDAT- 2010/09/28 06:00
MHDA- 2010/10/21 06:00
CRDT- 2010/09/28 06:00
PHST- 2010/09/28 06:00 [entrez]
PHST- 2010/09/28 06:00 [pubmed]
PHST- 2010/10/21 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2010 Summer;21(2):125-32.


PMID- 20866017
OWN - NLM
STAT- MEDLINE
DCOM- 20101020
LR  - 20151119
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 21
IP  - 2
DP  - 2010 Summer
TI  - Hope and patients' expectations in deep brain stimulation: healthcare providers' 
      perspectives and approaches.
PG  - 112-24
AB  - In this article we report relevant data that shed light on the topic of hope and 
      patients' expectations in the use of DBS, for standard, approved, and established
      indications, based on a broader qualitative study on the ethical and social
      challenges that healthcare providers face in the field of DBS.
FAU - Bell, Emily
AU  - Bell E
AD  - Neuroethics Research Unit, Institut de recherches cliniques de Montreal,
      Montreal, Quebec, Canada. emily.bell@ircm.qc.ca
FAU - Maxwell, Bruce
AU  - Maxwell B
FAU - McAndrews, Mary Pat
AU  - McAndrews MP
FAU - Sadikot, Abbas
AU  - Sadikot A
FAU - Racine, Eric
AU  - Racine E
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
MH  - Canada
MH  - *Deep Brain Stimulation/ethics/standards
MH  - *Emotions
MH  - Ethics, Clinical
MH  - Ethics, Research
MH  - *Health Personnel
MH  - Humans
MH  - *Mass Media
MH  - *Narration
MH  - Qualitative Research
MH  - Research Design
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
EDAT- 2010/09/28 06:00
MHDA- 2010/10/21 06:00
CRDT- 2010/09/28 06:00
PHST- 2010/09/28 06:00 [entrez]
PHST- 2010/09/28 06:00 [pubmed]
PHST- 2010/10/21 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2010 Summer;21(2):112-24.


PMID- 20866016
OWN - NLM
STAT- MEDLINE
DCOM- 20101020
LR  - 20100927
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 21
IP  - 2
DP  - 2010 Summer
TI  - Consent to deep brain stimulation for neurological and psychiatric disorders.
PG  - 104-11
AB  - Deep brain stimulation (DBS) of the globus pallidus interna and subthalamic
      nucleus has restored some degree of motor control in many patients in advanced
      stages of Parkinson's disease. DBS has also been used to treat dystonia,
      essential tremor (progressive neurological condition causing trembling), chronic 
      pain, obsessive-compulsive disorder, Tourette's syndrome, major depressive
      disorder, obesity, cerebral palsy, and the minimally conscious state. Although
      the underlying mechanisms of the technique are still not clear, DBS can modulate 
      underactive or overactive neural circuits and restore disrupted communication
      between and among groups of neurons in interacting regions of the brain.This can 
      control and relieve many symptoms associated with a range of neurological and
      psychiatric disorders. But the procedures of implanting and stimulating the
      electrodes are brain-invasive and entail significant risks. Some patients
      receiving DBS have experienced intracerebral hemorrhage, infection, cognitive
      disturbances such as impulsive behavior, and affective disturbances such as
      mania. It is not known whether continuous electrical stimulation of the brain
      would reshape synaptic connectivity and permanently alter neural circuits in ways
      that may not be salutary. The risk of these effects indicates that DBS should be 
      used only when a patient's condition is refractory to all other interventions and
      when there is a high probability that the technique will benefit the patient and 
      improve his or her quality of life. If a patient's quality of life is poor and
      all other treatment options have been exhausted, then the likelihood of benefit
      can justify physicians' exposing patients to some risk. The clinical and ethical 
      significance of the risk in DBS underscores the obligation of physicians to
      obtain fully informed consent from patients undergoing the procedure.
FAU - Glannon, Walter
AU  - Glannon W
AD  - Department of Philosophy, University of Calgary, Calgary, Alberta.
      wglannon@ucalgary.ca
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
MH  - Affect
MH  - Cognition
MH  - Cognition Disorders/etiology
MH  - Commitment of Mentally Ill
MH  - *Decision Making/ethics
MH  - *Deep Brain Stimulation/adverse effects/ethics
MH  - Hospitals, Psychiatric
MH  - Humans
MH  - *Informed Consent/ethics/psychology
MH  - Male
MH  - *Mental Competency
MH  - Mental Disorders/therapy
MH  - Middle Aged
MH  - Narration
MH  - Nervous System Diseases/therapy
MH  - Obsessive-Compulsive Disorder/psychology/*therapy
MH  - Parkinson Disease/physiopathology/psychology/*therapy
MH  - *Psychomotor Performance
MH  - Quality of Life
MH  - Withholding Treatment/ethics
EDAT- 2010/09/28 06:00
MHDA- 2010/10/21 06:00
CRDT- 2010/09/28 06:00
PHST- 2010/09/28 06:00 [entrez]
PHST- 2010/09/28 06:00 [pubmed]
PHST- 2010/10/21 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2010 Summer;21(2):104-11.


PMID- 20866015
OWN - NLM
STAT- MEDLINE
DCOM- 20101020
LR  - 20100927
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 21
IP  - 2
DP  - 2010 Summer
TI  - Deep brain stimulation, ethics, and society.
PG  - 101-3
AB  - Discussion surrounding ethical and social issues in deep brain stimulation (DBS) 
      has increased. This article introduces a special section on the ethics of DBS in 
      The Journal of Clinical Ethics.
FAU - Bell, Emily
AU  - Bell E
AD  - Institut de recherches cliniques de Montreal. eric.racine@ircm.qc.ca
FAU - Racine, Eric
AU  - Racine E
LA  - eng
PT  - Introductory Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
MH  - Conflict of Interest
MH  - Deep Brain Stimulation/adverse effects/economics/*ethics
MH  - Humans
MH  - Informed Consent/ethics
MH  - Intellectual Property
MH  - Interdisciplinary Communication
MH  - Mass Media
MH  - Narration
MH  - Parkinson Disease/psychology/*therapy
MH  - Personality
EDAT- 2010/09/28 06:00
MHDA- 2010/10/21 06:00
CRDT- 2010/09/28 06:00
PHST- 2010/09/28 06:00 [entrez]
PHST- 2010/09/28 06:00 [pubmed]
PHST- 2010/10/21 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2010 Summer;21(2):101-3.


PMID- 20866014
OWN - NLM
STAT- MEDLINE
DCOM- 20101020
LR  - 20100927
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 21
IP  - 2
DP  - 2010 Summer
TI  - Sliding "off" the sliding scale: allowing hope, determining capacity, and
      providing meaning when an illness is becoming worse but a treatment may help.
PG  - 91-100
AB  - In this issue of The Journal of Clinical Ethics, Emily Bell and Eric Racine are
      guest editors of a special section focusing on the use of deep brain stimulation 
      (DBS) to treat Parkinson's disease. In "Deep Brain Stimulation, Ethics, and
      Society," Bell and Racine report that DBS already has been used to treat more
      than 50,000 patients. The ethical issues raised in this special section are
      important not only in regard to Parkinson's disease and DBS, but in many areas of
      medicine. The articles discuss sound, state-of-the-art ethical approaches. This
      introduction to the issue presents approaches that are adjunctive and intended to
      increase careproviders' options, that should increase careproviders' ability to
      individualize the care that they provide to their patients.
FAU - Howe, Edmund G
AU  - Howe EG
AD  - Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
LA  - eng
PT  - Introductory Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
MH  - Anger
MH  - Anxiety/etiology
MH  - Deep Brain Stimulation/adverse effects/*ethics
MH  - Dementia/etiology
MH  - Depression/etiology
MH  - Emotions
MH  - Humans
MH  - Informed Consent/*psychology
MH  - *Interpersonal Relations
MH  - Memory Disorders/etiology
MH  - *Mental Competency
MH  - Parkinson Disease/*psychology/*therapy
MH  - Personal Autonomy
MH  - Personality
MH  - *Truth Disclosure
EDAT- 2010/09/28 06:00
MHDA- 2010/10/21 06:00
CRDT- 2010/09/28 06:00
PHST- 2010/09/28 06:00 [entrez]
PHST- 2010/09/28 06:00 [pubmed]
PHST- 2010/10/21 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2010 Summer;21(2):91-100.


PMID- 20865943
OWN - NLM
STAT- MEDLINE
DCOM- 20101101
LR  - 20190719
IS  - 0029-6570 (Print)
IS  - 0029-6570 (Linking)
VI  - 24
IP  - 50
DP  - 2010 Aug 18-24
TI  - Shopping bad service.
PG  - 20-2
AB  - Mystery shoppers are well established in the retail trade. But their introduction
      to health services--particularly in mental health--raises ethical issues.
FAU - Sadler, Catharine
AU  - Sadler C
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Stand
JT  - Nursing standard (Royal College of Nursing (Great Britain) : 1987)
JID - 9012906
MH  - *Consumer Behavior
MH  - Delivery of Health Care/*standards
MH  - Humans
MH  - Quality Assurance, Health Care/methods
EDAT- 2010/09/28 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/09/28 06:00
PHST- 2010/09/28 06:00 [entrez]
PHST- 2010/09/28 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - 10.7748/ns.24.50.20.s25 [doi]
PST - ppublish
SO  - Nurs Stand. 2010 Aug 18-24;24(50):20-2. doi: 10.7748/ns.24.50.20.s25.


PMID- 20865875
OWN - NLM
STAT- MEDLINE
DCOM- 20101026
LR  - 20220408
IS  - 0310-057X (Print)
IS  - 0310-057X (Linking)
VI  - 38
IP  - 5
DP  - 2010 Sep
TI  - Comparison of automated intermittent low volume bolus with continuous infusion
      for labour epidural analgesia.
PG  - 894-9
AB  - Delivery of local anaesthetics via automated intermittent bolus has been shown to
      improve epidural analgesia compared to delivery via continuous epidural infusion.
      However the optimal bolus volume has not been investigated. This randomised,
      double-blind study compared the analgesic efficacy of automated intermittent
      bolus (volume 2.5 ml every 15 minutes) with that of a continuous epidural
      infusion (10 ml/hour) for the maintenance of labour epidural analgesia, to
      determine whether the advantages previously demonstrated for automated
      intermittent bolus over continuous epidural infusion are retained at this low
      bolus volume. With the approval of the Hospital Ethics Committee, we recruited 50
      parturients who received combined spinal epidural analgesia with intrathecal
      ropivacaine 2 mg and fentanyl 15 microg. For epidural maintenance, participants
      were randomised to either the automated intermittent bolus group (2.5 ml
      automated intermittent epidural boluses of ropivacaine 0.1% plus fentanyl 2
      microg/ml delivered over a two-minute period every 15 minutes) or the continuous 
      epidural infusion group (continuous epidural infusion of ropivacaine 0.1% plus
      fentanyl 2 microg/ml at 10 ml/hour). The primary study outcome was the incidence 
      of pain during labour that required management with supplemental epidural
      analgesia. There were no significant differences between the two regimens in
      terms of breakthrough pain (automated intermittent bolus 36% [9/25] vs continuous
      epidural infusion 32% [8/25], P = 0.77). At the doses used in this study,
      maintenance of labour analgesia using automated intermittent bolus at a bolus
      volume of 2.5 ml every 15 minutes does not decrease the incidence of breakthrough
      pain or improve analgesic efficacy compared to continuous epidural infusion.
FAU - Lim, Y
AU  - Lim Y
AD  - Department of Women's Anaesthesia, Kandang Kerbau Women's and Children's
      Hospital, Singapore. YVEL6@hotmail.com
FAU - Chakravarty, S
AU  - Chakravarty S
FAU - Ocampo, C E
AU  - Ocampo CE
FAU - Sia, A T
AU  - Sia AT
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Anaesth Intensive Care
JT  - Anaesthesia and intensive care
JID - 0342017
RN  - 0 (Amides)
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Anesthetics, Local)
RN  - 7IO5LYA57N (Ropivacaine)
RN  - UF599785JZ (Fentanyl)
SB  - IM
MH  - Amides/administration & dosage
MH  - Analgesia, Epidural/*methods
MH  - Analgesia, Obstetrical/*methods
MH  - Analgesics, Opioid/administration & dosage
MH  - Anesthetics, Local/administration & dosage
MH  - Double-Blind Method
MH  - Drug Administration Schedule
MH  - Drug Therapy, Combination
MH  - Female
MH  - Fentanyl/administration & dosage
MH  - Humans
MH  - Labor Pain/*drug therapy
MH  - Pregnancy
MH  - Ropivacaine
EDAT- 2010/09/28 06:00
MHDA- 2010/10/27 06:00
CRDT- 2010/09/28 06:00
PHST- 2010/09/28 06:00 [entrez]
PHST- 2010/09/28 06:00 [pubmed]
PHST- 2010/10/27 06:00 [medline]
AID - 20090890 [pii]
AID - 10.1177/0310057X1003800514 [doi]
PST - ppublish
SO  - Anaesth Intensive Care. 2010 Sep;38(5):894-9. doi: 10.1177/0310057X1003800514.


PMID- 20865865
OWN - NLM
STAT- MEDLINE
DCOM- 20101026
LR  - 20190319
IS  - 0310-057X (Print)
IS  - 0310-057X (Linking)
VI  - 38
IP  - 5
DP  - 2010 Sep
TI  - Informed consent for anaesthesia in Australia and New Zealand.
PG  - 809-22
AB  - The legal and ethical requirements related to an anaesthetist's communication
      with patients in preparing them for anaesthesia, assisting them in making
      appropriate decisions and obtaining consent in a formal sense are complex. Doing 
      these things well takes time, skill and sensitivity. The primary focus should be 
      to adequately prepare patients for surgery and to ensure that they are
      sufficiently well informed to make the choices that best meet their own needs.
      This is just an affirmation of the importance of patient-centred care.
FAU - Braun, A R
AU  - Braun AR
AD  - Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Faculty 
      of Law and Medicine, University of Melbourne, Melbourne, Victoria, Australia.
FAU - Skene, L
AU  - Skene L
FAU - Merry, A F
AU  - Merry AF
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Anaesth Intensive Care
JT  - Anaesthesia and intensive care
JID - 0342017
RN  - 0 (Anesthetics)
SB  - IM
CIN - Anaesth Intensive Care. 2010 Sep;38(5):797. PMID: 20865862
CIN - Anaesth Intensive Care. 2011 Jan;39(1):132; author reply 132. PMID: 21375105
MH  - Anesthesia/*adverse effects/ethics
MH  - Anesthesiology/ethics/legislation & jurisprudence
MH  - Anesthetics/*adverse effects
MH  - Australia
MH  - Communication
MH  - Humans
MH  - *Informed Consent
MH  - New Zealand
MH  - Patient-Centered Care/methods
EDAT- 2010/09/28 06:00
MHDA- 2010/10/27 06:00
CRDT- 2010/09/28 06:00
PHST- 2010/09/28 06:00 [entrez]
PHST- 2010/09/28 06:00 [pubmed]
PHST- 2010/10/27 06:00 [medline]
AID - 20090994 [pii]
AID - 10.1177/0310057X1003800504 [doi]
PST - ppublish
SO  - Anaesth Intensive Care. 2010 Sep;38(5):809-22. doi: 10.1177/0310057X1003800504.


PMID- 20865584
OWN - NLM
STAT- MEDLINE
DCOM- 20110202
LR  - 20141120
IS  - 2458-9446 (Electronic)
IS  - 1300-0012 (Linking)
VI  - 22
IP  - 3
DP  - 2010 Jul
TI  - [Comparison of the activity and reliability of intravenous administration of
      midazolam and dexmedetomidine on sedation levels under epidural anesthesia].
PG  - 121-30
AB  - OBJECTIVES: We aimed to assess the sedative effects of midazolam and
      dexmedetomidine and their effects on hemodynamics and the cardiovascular system
      under epidural anesthesia. METHODS: This study included 50 patients. Approval of 
      the ethics committee and written consent from patients were obtained. The
      patients were separated into two groups to receive dexmedetomidine (D group) or
      midazolam (M group). Perifix no. 18 was placed in the epidural space from the
      L(3-4) interspace. After lidocaine 60 mg/3 ml was applied, isobaric bupivacaine
      0.5% was given as 1 ml per segment. After block reached the T10 level, midazolam 
      was given to the M group as a bolus of 0.015 mg kg(-1) in 10 minutes until
      beginning the operation, followed by continuous infusion as 0.1-0.2 mg
      kg(-1)h(-1) dosage. Dexmedetomidine 1 mcq kg(-1) was given to the D group as a
      bolus dosage in 10 minutes until beginning the operation, followed by continuous 
      infusion as 0.4-0.7 mcq kg(-1) h(-1) dosage. Systolic arterial pressure (SAP),
      diastolic arterial pressure (DAP), mean arterial pressure (MAP), heart rate (HR),
      SpO(2), Ramsay Sedation Score (RSS), bispectral index (BIS), and respiratory rate
      (RR) were recorded. Sedative infusion was stopped when skin suture was closed.
      Adverse effects were also recorded. RESULTS: In group D, MAP was significantly
      higher and HR was significantly lower than in group M (p<0.05). CONCLUSION: We
      concluded that both drugs provided good sedation with no respiratory depression, 
      stable hemodynamics and alertness with good cooperation. However, we consider
      midazolam as the first option due to its cost benefit.
FAU - Kuzucuoglu, Tamer
AU  - Kuzucuoglu T
AD  - 1st Department of Anesthesiology and Reanimation, Dr. Lutfi Kirdar Kartal
      Training and Research Hospital, Istanbul, Turkey. tamer.kuzucuoglu@sbkeah.gov.tr
FAU - Bolukbasioglu, Ilhan
AU  - Bolukbasioglu I
FAU - Arslan, Gulten
AU  - Arslan G
FAU - Yucel, Emre
AU  - Yucel E
FAU - Ayaz, Betul
AU  - Ayaz B
LA  - tur
PT  - Clinical Trial
PT  - English Abstract
PT  - Journal Article
TT  - Epidural anestezi altinda intravenoz midazolam ve deksmedetomidin kullaniminin
      sedasyon duzeyleri uzerine etkinlik ve guvenirliginin karsilastirilmasi
PL  - Turkey
TA  - Agri
JT  - Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish
      Society of Algology
JID - 9426197
RN  - 0 (Analgesics, Non-Narcotic)
RN  - 0 (Anesthetics, Intravenous)
RN  - 0 (Hypnotics and Sedatives)
RN  - 67VB76HONO (Dexmedetomidine)
RN  - R60L0SM5BC (Midazolam)
RN  - Y8335394RO (Bupivacaine)
SB  - IM
MH  - Adult
MH  - Analgesics, Non-Narcotic/administration & dosage/therapeutic use
MH  - Anesthesia, Epidural
MH  - Anesthetics, Intravenous/administration & dosage/economics/therapeutic use
MH  - Blood Pressure/drug effects
MH  - Bupivacaine/administration & dosage/therapeutic use
MH  - Costs and Cost Analysis
MH  - Dexmedetomidine/administration & dosage/*therapeutic use
MH  - Elective Surgical Procedures
MH  - Female
MH  - Heart Rate/drug effects
MH  - Humans
MH  - Hypnotics and Sedatives/administration & dosage/therapeutic use
MH  - Hysterectomy
MH  - Infusions, Intravenous
MH  - Midazolam/administration & dosage/economics/*therapeutic use
MH  - Middle Aged
MH  - Respiratory Rate/drug effects/physiology
EDAT- 2010/09/25 06:00
MHDA- 2011/02/03 06:00
CRDT- 2010/09/25 06:00
PHST- 2010/09/25 06:00 [entrez]
PHST- 2010/09/25 06:00 [pubmed]
PHST- 2011/02/03 06:00 [medline]
PST - ppublish
SO  - Agri. 2010 Jul;22(3):121-30.


PMID- 20865583
OWN - NLM
STAT- MEDLINE
DCOM- 20110202
LR  - 20220409
IS  - 2458-9446 (Electronic)
IS  - 1300-0012 (Linking)
VI  - 22
IP  - 3
DP  - 2010 Jul
TI  - [Postoperative pain therapy after laparoscopic cholecystectomy: paracetamol
      versus diclofenac].
PG  - 117-20
AB  - OBJECTIVES: Laparoscopic cholecystectomy is the first treatment choice for
      symptomatic gallstone disease. We compared the efficacy of intravenous (i.v.)
      paracetamol and intramuscular (i.m.) diclofenac Na(+) after laparoscopic
      cholecystectomy. METHODS: Following approval from the Local Ethics Committee and 
      receipt of written informed consent, 40 ASA physical status I-II patients who
      underwent laparoscopic cholecystectomy were enrolled into the study. General
      anesthesia was standardized. The patients received 1 g i.v. Paracetamol (Group I,
      n: 20) or 75 mg diclofenac Na+ i.m. (Group II, n: 20) 15 minutes (min) before the
      end of the operation. Pain was assessed by numeric rating scale (NRS) after
      arrival in the postanesthesia care unit (PACU) (NRS 1) and at the 30th minute
      (NRS 2) and 1st hour (NRS 3) of the PACU stay. 10 mg i.v. Pethidine HCL was
      administered to the patient with NRS >5. The following measures were recorded:
      intensity of pain by NRS at arrival and after 30 and 60 min, total consumption of
      pethidine HCL, and nausea and vomiting. RESULTS: All assessments were performed
      by an anesthesiologist blinded to the study protocol. NRS 3 scores were
      significantly higher in Group I than Group II (p<0.05). Opioid consumption was
      not different between the groups. Two patients in each group had postoperative
      nausea and vomiting; no other adverse effects were noted. CONCLUSION: We
      recommend the use of i.v. Paracetamol as an opioid adjuvant. Regarding its use as
      a unique drug for postoperative pain therapy, further comparative studies with
      higher doses of paracetamol are needed.
FAU - Durak, Pinar
AU  - Durak P
AD  - Department of Anesthesiology and Reanimation, Turkiye Yuksek Ihtisas Education
      and Research Hospital, Turkey.
FAU - Yagar, Seyhan
AU  - Yagar S
FAU - Uzuner, Ali
AU  - Uzuner A
FAU - Kilic, Mehmet
AU  - Kilic M
FAU - Dilber, Elif
AU  - Dilber E
FAU - Ozgok, Aysegul
AU  - Ozgok A
LA  - tur
PT  - Clinical Trial
PT  - English Abstract
PT  - Journal Article
TT  - Laparoskopik kolesistektomilerde cerrahi sonrasi agri tedavisi: Parasetamol ile
      diklofenak karsilastirmasi
PL  - Turkey
TA  - Agri
JT  - Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish
      Society of Algology
JID - 9426197
RN  - 0 (Analgesics, Non-Narcotic)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 144O8QL0L1 (Diclofenac)
RN  - 362O9ITL9D (Acetaminophen)
SB  - IM
MH  - Acetaminophen/administration & dosage/*therapeutic use
MH  - Analgesics, Non-Narcotic/administration & dosage/therapeutic use
MH  - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/therapeutic use
MH  - Cholecystectomy, Laparoscopic/*methods
MH  - Diclofenac/administration & dosage/*therapeutic use
MH  - Dose-Response Relationship, Drug
MH  - Humans
MH  - Pain Measurement
MH  - Pain, Postoperative/*drug therapy
MH  - Postoperative Period
EDAT- 2010/09/25 06:00
MHDA- 2011/02/03 06:00
CRDT- 2010/09/25 06:00
PHST- 2010/09/25 06:00 [entrez]
PHST- 2010/09/25 06:00 [pubmed]
PHST- 2011/02/03 06:00 [medline]
PST - ppublish
SO  - Agri. 2010 Jul;22(3):117-20.


PMID- 20865076
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20211020
IS  - 1564-0604 (Electronic)
IS  - 0042-9686 (Linking)
VI  - 88
IP  - 9
DP  - 2010 Sep 1
TI  - Rethinking HIV exceptionalism: the ethics of opt-out HIV testing in sub-Saharan
      Africa.
PG  - 703-8
LID - 10.2471/BLT.09.073049 [doi]
AB  - Opt-out testing for the human immunodeficiency virus (HIV) incorporates testing
      as a routine part of health care for all patients unless they refuse. The ethics 
      of this approach to testing in sub-Saharan Africa is a source of controversy.
      Opt-out HIV testing is expected to improve survival by increasing case detection 
      and thus linking more HIV-infected people to earlier treatment, provided there is
      effective patient follow-up and programme sustainability. At the population
      level, these benefits will likely outweigh the potential negative consequences of
      individuals experiencing HIV-related stigma. These justifications appeal to
      consequentialist moral theories that the acceptability of an action depends upon 
      its outcomes. On the other hand, liberal moral theories state that the autonomy
      of individuals should always be protected unless restricting autonomy is
      necessary to protect the welfare of others. Opt-out consent may restrict autonomy
      and it is unclear whether it would benefit people other than those being tested. 
      Yet, the doctrine of libertarian paternalism proposes that it is justifiable and 
      desirable to use unobtrusive mechanisms to help individuals make choices to
      maximize their own welfare. Central to this idea are the premises featured by
      supporters of opt-out consent that individuals will not always make the best
      choices for their own welfare but they may be influenced to do so in ways that
      will not compromise their freedom of choice. Also important is the premise that
      all policies inevitably exert some such influence: opt-in consent encourages test
      refusal just as opt-out consent encourages acceptance. Based on these premises,
      opt-out testing may be an effective and ethically acceptable policy response to
      Africa's HIV epidemic.
FAU - April, Michael D
AU  - April MD
AD  - Harvard Medical School, Boston, MA 02115, United States of America.
      Michael_April@hms.harvard.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100625
PL  - Switzerland
TA  - Bull World Health Organ
JT  - Bulletin of the World Health Organization
JID - 7507052
RN  - 0 (Anti-Retroviral Agents)
SB  - IM
MH  - Africa South of the Sahara
MH  - Anti-Retroviral Agents/therapeutic use
MH  - HIV Infections/*diagnosis/drug therapy/psychology
MH  - Humans
MH  - Paternalism
MH  - Prejudice
MH  - Primary Health Care/*ethics/*methods
PMC - PMC2930364
EDAT- 2010/09/25 06:00
MHDA- 2011/01/07 06:00
CRDT- 2010/09/25 06:00
PHST- 2009/10/05 00:00 [received]
PHST- 2009/12/11 00:00 [revised]
PHST- 2010/01/05 00:00 [accepted]
PHST- 2010/09/25 06:00 [entrez]
PHST- 2010/09/25 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
AID - 10.2471/BLT.09.073049 [doi]
PST - ppublish
SO  - Bull World Health Organ. 2010 Sep 1;88(9):703-8. doi: 10.2471/BLT.09.073049. Epub
      2010 Jun 25.


PMID- 20864322
OWN - NLM
STAT- MEDLINE
DCOM- 20110225
LR  - 20131121
IS  - 1769-664X (Electronic)
IS  - 0929-693X (Linking)
VI  - 17
IP  - 10
DP  - 2010 Oct
TI  - [The use of postnatal corticosteroid therapy in premature infants to prevent or
      treat bronchopulmonary dysplasia: current situation and recommendations].
PG  - 1480-7
LID - 10.1016/j.arcped.2010.07.013 [doi]
AB  - In the last few years, several studies related to the benefit/risk balance of
      postnatal corticosteroids administered to premature neonates for prevention or
      treatment of bronchopulmonary dysplasia (BPD) have been published. These data
      encourage caution, given the risk of long-term adverse neurodevelopmental
      outcomes. In the meantime, the clinical profile of BPD has been altered based on 
      the progress made in the pre- and postnatal care of premature infants. In 2006, a
      survey conducted in France in neonatal centers showed that corticosteroids were
      still frequently used (57% of the centers) following various protocols in very
      preterm-born infants for respiratory impairment. To promote safer practices and
      rational use of corticosteroids in the prevention and treatment of BPD in
      preterm-born neonates, we reviewed the available data in order to establish
      recommendations. Systemic administration of corticosteroids for prevention or
      treatment of BPD: (i) should not be used during the first 4 days of life; (ii) is
      not indicated in the first 3 weeks of life nor (iii) in extubated infants (nasal 
      ventilation or oxygen therapy). The systemic administration of steroids can only 
      be considered after the first 3 weeks of life in very preterm-born
      ventilator-dependent infants to facilitate extubation (or prevent reintubation
      related to the severity of BPD). Postnatal dexamethasone administration studied
      in several randomized clinical trials was shown to have an unfavorable
      benefit/risk profile, mainly because of the long-term adverse neurocognitive
      outcomes. Very few studies have been conducted with betamethasone in the
      postnatal period. According to sparse data, this drug might be as efficacious as 
      dexamethasone, but its long-term risk profile is unknown. It should be noted that
      following prenatal administration, the benefit/risk profile of betamethasone is
      better than that of dexamethasone, especially with regard to neurocognitive
      development. Intravenous hydrocortisone administered at an early stage for the
      prevention of BPD is being evaluated and should not be administered in this
      indication, except within clinical trials approved by the ethics committee. No
      other corticosteroids have been evaluated in the postnatal period in respiratory 
      indications. In conclusion, in the situations described above for which systemic 
      corticosteroids could be justified, the use of betamethasone (or hydrocortisone) 
      appears to be better. As usual, the lowest possible dose of corticosteroids
      should be administered for the shortest possible duration. The
      betamethasone-equivalent dose of 0.125 mg/kg/day for 3 days is deemed adequate.
      If inhaled, corticosteroid therapy may facilitate extubation. Neither its
      efficacy in respiratory diseases nor its long-term risk profile has been so far
      established.
CI  - Copyright (c) 2010. Published by Elsevier SAS.. All rights reserved.
FAU - Jarreau, P-H
AU  - Jarreau PH
AD  - Service de medecine neonatale de Port-Royal, centre hospitalier
      Cochin-St-Vincent-de-Paul, 123, boulevard de Port-Royal, 75014 Paris, France.
FAU - Fayon, M
AU  - Fayon M
FAU - Baud, O
AU  - Baud O
FAU - Autret-Leca, E
AU  - Autret-Leca E
FAU - Danan, M
AU  - Danan M
FAU - de Verdelhan, A
AU  - de Verdelhan A
FAU - Castot, A
AU  - Castot A
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Utilisation de la corticotherapie postnatale chez le nouveau-ne premature dans la
      prevention et le traitement de la dysplasie bronchopulmonaire : etat des lieux et
      conduite a tenir.
DEP - 20100922
PL  - France
TA  - Arch Pediatr
JT  - Archives de pediatrie : organe officiel de la Societe francaise de pediatrie
JID - 9421356
RN  - 0 (Adrenal Cortex Hormones)
RN  - 9842X06Q6M (Betamethasone)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adrenal Cortex Hormones/adverse effects/*therapeutic use
MH  - Betamethasone/therapeutic use
MH  - Brain/drug effects
MH  - Bronchopulmonary Dysplasia/*drug therapy/prevention & control
MH  - France
MH  - Humans
MH  - Hydrocortisone/therapeutic use
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Infant, Premature, Diseases/*drug therapy/prevention & control
MH  - Postnatal Care/standards
MH  - Prenatal Care/standards
MH  - Respiratory System/drug effects
EDAT- 2010/09/25 06:00
MHDA- 2011/02/26 06:00
CRDT- 2010/09/25 06:00
PHST- 2009/10/27 00:00 [received]
PHST- 2010/06/30 00:00 [revised]
PHST- 2010/07/14 00:00 [accepted]
PHST- 2010/09/25 06:00 [entrez]
PHST- 2010/09/25 06:00 [pubmed]
PHST- 2011/02/26 06:00 [medline]
AID - S0929-693X(10)00307-6 [pii]
AID - 10.1016/j.arcped.2010.07.013 [doi]
PST - ppublish
SO  - Arch Pediatr. 2010 Oct;17(10):1480-7. doi: 10.1016/j.arcped.2010.07.013. Epub
      2010 Sep 22.


PMID- 20864297
OWN - NLM
STAT- MEDLINE
DCOM- 20110131
LR  - 20171116
IS  - 1097-6809 (Electronic)
IS  - 0741-5214 (Linking)
VI  - 53
IP  - 1
DP  - 2011 Jan
TI  - Open repair of abdominal aortic aneurysm in a centenarian.
PG  - 216-8
LID - 10.1016/j.jvs.2010.07.046 [doi]
AB  - We present the case of a 101-year-old female who was successfully operated for an
      open elective repair of a symptomatic 9 cm abdominal aortic aneurysm. This is the
      oldest case reported in the literature for elective open abdominal aortic
      aneurysm repair with successful outcome. This case raises an important ethical
      issue of human life expectancy and the appropriateness of high-risk surgery on a 
      centenarian.
CI  - Copyright (c) 2011 Society for Vascular Surgery. Published by Mosby, Inc. All
      rights reserved.
FAU - Lath, Nikesh R
AU  - Lath NR
AD  - Columbia University, College of Physicians and Surgeons, Affiliation at Harlem
      Hospital, New York, NY, USA.
FAU - Rai, Kumar
AU  - Rai K
FAU - Alshafie, Tarek
AU  - Alshafie T
LA  - eng
PT  - Journal Article
DEP - 20100922
PL  - United States
TA  - J Vasc Surg
JT  - Journal of vascular surgery
JID - 8407742
SB  - IM
MH  - Aged, 80 and over
MH  - Aortic Aneurysm, Abdominal/diagnostic imaging/*surgery
MH  - Bioethical Issues
MH  - Contraindications
MH  - Elective Surgical Procedures
MH  - Female
MH  - Humans
MH  - Life Expectancy
MH  - Radiography
MH  - Risk Assessment
MH  - Vascular Surgical Procedures/ethics
EDAT- 2010/09/25 06:00
MHDA- 2011/02/01 06:00
CRDT- 2010/09/25 06:00
PHST- 2010/04/30 00:00 [received]
PHST- 2010/07/19 00:00 [revised]
PHST- 2010/07/20 00:00 [accepted]
PHST- 2010/09/25 06:00 [entrez]
PHST- 2010/09/25 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
AID - S0741-5214(10)01823-9 [pii]
AID - 10.1016/j.jvs.2010.07.046 [doi]
PST - ppublish
SO  - J Vasc Surg. 2011 Jan;53(1):216-8. doi: 10.1016/j.jvs.2010.07.046. Epub 2010 Sep 
      22.


PMID- 20864125
OWN - NLM
STAT- MEDLINE
DCOM- 20110128
LR  - 20101018
IS  - 1878-5883 (Electronic)
IS  - 0022-510X (Linking)
VI  - 298
IP  - 1-2
DP  - 2010 Nov 15
TI  - Enhancing trophic support of mesenchymal stem cells by ex vivo treatment with
      trophic factors.
PG  - 28-34
LID - 10.1016/j.jns.2010.09.003 [doi]
AB  - BACKGROUND: Several studies have examined the enhanced efficacy of mesenchymal
      stem cells (MSCs) using neurotrophic factor transfection in ischemic rat models. 
      However, gene therapy, e.g., the application of MSCs transfected with
      neurotrophic factors, is not feasible in clinical practice for ethical reasons.
      Therefore, we evaluated cultivation with specific trophic factors in an attempt
      to enhance the efficacy of human MSCs (hMSCs) in ischemic stroke. METHODS: Using 
      quantitative sandwich enzyme-linked immunosorbent assay (ELISA), we analyzed the 
      levels of trophic factors released from hMSCs after treatment with ischemic brain
      extract. Trophic factors were pretreated under ex vivo culture conditions. The
      concentrations of each trophic factor produced by the trophic factor-pretreated
      and non-pretreated hMSCs were then measured and compared. RESULTS: hMSCs cultured
      with ischemic rat brain extract showed increased production of BDNF
      (brain-derived neurotrophic factor), VEGF (vascular endothelial growth factor)
      and HGF (hepatocyte growth factor). Ex vivo treatment with trophic factors led to
      a further increase in the production of the trophic factor by hMSC, suggesting
      autocrine regulation of hMSCs. The morphology and expression of surface markers
      of hMSCs were not changed, but the cell viability and cell proliferation ability 
      increased after treatment with trophic factors. CONCLUSIONS: Our data indicate
      that hMSCs provide trophic support to the ischemic brain, which can be enhanced
      by ex vivo treatment of trophic factors during cultivation of hMSCs.
CI  - Copyright (c) 2010 Elsevier B.V. All rights reserved.
FAU - Choi, Yun Jung
AU  - Choi YJ
AD  - Brain Disease Research Center, Department of Neurosurgery, Ajou University School
      of Medicine, Suwon, Republic of Korea.
FAU - Li, Wen Yu
AU  - Li WY
FAU - Moon, Gyeong Joon
AU  - Moon GJ
FAU - Lee, Phil Hyu
AU  - Lee PH
FAU - Ahn, Young Hwan
AU  - Ahn YH
FAU - Lee, Gwang
AU  - Lee G
FAU - Bang, Oh Young
AU  - Bang OY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100922
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
SB  - IM
MH  - Animals
MH  - Brain Ischemia/complications/*therapy
MH  - Brain-Derived Neurotrophic Factor/therapeutic use
MH  - Cell Separation
MH  - Cell Survival
MH  - Cells, Cultured
MH  - Dose-Response Relationship, Drug
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Hepatocyte Growth Factor/therapeutic use
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins/administration &
      dosage/*therapeutic use
MH  - Male
MH  - Mesenchymal Stem Cell Transplantation/*methods
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Rats, Wistar
MH  - Stroke/etiology/*therapy
MH  - Vascular Endothelial Growth Factor A/therapeutic use
EDAT- 2010/09/25 06:00
MHDA- 2011/02/01 06:00
CRDT- 2010/09/25 06:00
PHST- 2009/11/26 00:00 [received]
PHST- 2010/08/18 00:00 [revised]
PHST- 2010/09/01 00:00 [accepted]
PHST- 2010/09/25 06:00 [entrez]
PHST- 2010/09/25 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
AID - S0022-510X(10)00439-9 [pii]
AID - 10.1016/j.jns.2010.09.003 [doi]
PST - ppublish
SO  - J Neurol Sci. 2010 Nov 15;298(1-2):28-34. doi: 10.1016/j.jns.2010.09.003. Epub
      2010 Sep 22.


PMID- 20863185
OWN - NLM
STAT- MEDLINE
DCOM- 20110107
LR  - 20100924
IS  - 1440-1665 (Electronic)
IS  - 1039-8562 (Linking)
VI  - 18
IP  - 5
DP  - 2010 Oct
TI  - Borderline personality disorder: exceptions to the concept of responsible and
      competent.
PG  - 445-50
LID - 10.3109/10398562.2010.500669 [doi]
AB  - AIM: This article examines whether neurocognitive deficits or age prevents people
      with borderline personality disorder from being considered responsible and
      competent. METHOD: A review of the literature was undertaken relating to
      borderline personality disorder (BPD), personal responsibility and competency.
      RESULT: Neither neurobiological differences nor age automatically disqualify the 
      person with BPD from being responsible and competent for decisions relating to
      their own life and death. CONCLUSION: Clinical, legal and ethical literature
      support this result and thereby re-establishes a basis for the recognition and
      respect of an individual's dignity.
FAU - Little, John
AU  - Little J
AD  - Grampians Psychiatric Services, Grampians, Victoria, Australia.
      john.little@cft.cornwall.nhs.uk
FAU - Little, Bridget
AU  - Little B
LA  - eng
PT  - Journal Article
PL  - England
TA  - Australas Psychiatry
JT  - Australasian psychiatry : bulletin of Royal Australian and New Zealand College of
      Psychiatrists
JID - 9613603
SB  - IM
MH  - Aging/psychology
MH  - Borderline Personality Disorder/*psychology
MH  - Cognition Disorders/etiology/psychology
MH  - Decision Making
MH  - Humans
MH  - Mental Competency
MH  - Psychiatry/ethics
MH  - Social Responsibility
MH  - Suicide, Attempted/psychology
EDAT- 2010/09/25 06:00
MHDA- 2011/01/08 06:00
CRDT- 2010/09/25 06:00
PHST- 2010/09/25 06:00 [entrez]
PHST- 2010/09/25 06:00 [pubmed]
PHST- 2011/01/08 06:00 [medline]
AID - 10.3109/10398562.2010.500669 [doi]
PST - ppublish
SO  - Australas Psychiatry. 2010 Oct;18(5):445-50. doi: 10.3109/10398562.2010.500669.


PMID- 20863146
OWN - NLM
STAT- MEDLINE
DCOM- 20110121
LR  - 20181201
IS  - 1445-6354 (Electronic)
IS  - 1445-6354 (Linking)
VI  - 10
IP  - 3
DP  - 2010 Jul-Sep
TI  - Overseas trained nurses working in regional and rural practice settings: do we
      understand the issues?
PG  - 1458
AB  - INTRODUCTION: Issues associated with the employment of overseas trained nurses
      (OTNs) in regional and rural practice settings have received little professional 
      attention in Australia. The global nursing workforce crisis has dominated
      discussion about the migration of nurses. This review explored the contemporary
      understandings of the employment of OTNs in Australian regional and rural
      practice settings. METHODS: An integrative literature review was undertaken to
      incorporate a range of literature types related to OTN employment. A search of
      electronic databases and relevant web pages was undertaken for the publication
      period 1995-2008. Integrative literature reviews incorporate assessment of
      empirical research as well as theoretical and opinion-based literature to present
      a broad synthesis of the topic of interest. Following identification of relevant 
      literature, thematic analysis was undertaken to reveal patterns and relationships
      among concepts facilitating synthesis of findings across the range of literature.
      RESULTS: There is an abundance of literature exploring the international
      migration of nurses that demonstrates an imbalance of migration from poorer
      countries to more affluent countries. This review identified a number of economic
      and ethical issues, together with risks for potential exploitation of migrant
      nurses. There was minimal literature specific to the experiences of OTNs working 
      in regional and rural areas. However, there has been some exploration of issues
      associated with medical recruitment to rural areas. CONCLUSIONS: The employment
      of OTNs is accompanied by complex and varied issues which require resourceful and
      proactive responses by healthcare employers. Further research is needed to
      understand the challenges OTNs have in working in rural settings, particularly in
      Australia. Increased understanding in clinical settings of factors that influence
      nurses to migrate, as well as the range of barriers they face in working and
      living in host countries, may assist in the retention of these nurses.
FAU - Wellard, S J
AU  - Wellard SJ
AD  - School of Nursing, University of Ballarat, Ballarat, Victoria, Australia.
      s.wellard@ballarat.edu.au
FAU - Stockhausen, L J
AU  - Stockhausen LJ
LA  - eng
PT  - Journal Article
DEP - 20100920
PL  - Australia
TA  - Rural Remote Health
JT  - Rural and remote health
JID - 101174860
SB  - IM
MH  - Australia
MH  - Emigration and Immigration/trends
MH  - *Foreign Professional Personnel
MH  - Humans
MH  - Nursing Staff/*supply & distribution
MH  - *Personnel Selection/ethics
MH  - *Rural Health Services
MH  - Workforce
EDAT- 2010/09/25 06:00
MHDA- 2011/01/22 06:00
CRDT- 2010/09/25 06:00
PHST- 2010/09/25 06:00 [entrez]
PHST- 2010/09/25 06:00 [pubmed]
PHST- 2011/01/22 06:00 [medline]
AID - 1458 [pii]
PST - ppublish
SO  - Rural Remote Health. 2010 Jul-Sep;10(3):1458. Epub 2010 Sep 20.


PMID- 20840568
OWN - NLM
STAT- MEDLINE
DCOM- 20110412
LR  - 20220410
IS  - 1600-0838 (Electronic)
IS  - 0905-7188 (Linking)
VI  - 20 Suppl 2
DP  - 2010 Oct
TI  - Psychology and socioculture affect injury risk, response, and recovery in
      high-intensity athletes: a consensus statement.
PG  - 103-11
LID - 10.1111/j.1600-0838.2010.01195.x [doi]
AB  - This consensus statement summarizes key contemporary research themes relevant to 
      understanding the psychology and socioculture of sport injury. Special
      consideration is given toward high-intensity sport in which elite athlete
      training and performance efforts are characterized by explosive physical speed
      and strength, mental fortitude to push physical limits, and maximum effort and
      commitment to highly challenging goals associated with achieving exceptional
      performance. Sport injury occurrence in high-intensity sport is an adverse and
      stressful health event associated with a complex multitude of risks, consequences
      and outcomes. A biopsychosocial (Engel, 1980) view is advocated which
      contextualizes an understanding of the psychological aspects of sport injury in
      light of influential sociocultural, ethical, and biomedical issues. Outcomes
      related to athlete health and performance excellence are of equal importance in
      considering how psychological scholarship, expertise and services can be used to 
      improve efforts focused on the prevention and management of sport injury among
      high-intensity athletes. The consensus view is that psychology and socioculture
      do affect sport injury risk, response and recovery in high-intensity athletes,
      and that continued efforts in psychological research and professional practice
      are needed to protect athlete physical and mental health and contribute toward
      performance excellence and career longevity.
CI  - (c) 2010 John Wiley & Sons A/S.
FAU - Wiese-Bjornstal, D M
AU  - Wiese-Bjornstal DM
AD  - School of Kinesiology, University of Minnesota, Minneapolis, Minnesota, USA.
      dwiese@umn.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Denmark
TA  - Scand J Med Sci Sports
JT  - Scandinavian journal of medicine & science in sports
JID - 9111504
SB  - IM
MH  - Athletic Injuries/*epidemiology/psychology/rehabilitation
MH  - Caregivers/psychology
MH  - *Culture
MH  - Humans
MH  - Isometric Contraction/*physiology
MH  - Muscle, Skeletal/*injuries/physiology
MH  - Risk Assessment
MH  - Socioeconomic Factors
MH  - *Sports Medicine
MH  - Treatment Outcome
MH  - United States/epidemiology
EDAT- 2010/09/25 06:00
MHDA- 2011/04/13 06:00
CRDT- 2010/09/16 06:00
PHST- 2010/09/16 06:00 [entrez]
PHST- 2010/09/25 06:00 [pubmed]
PHST- 2011/04/13 06:00 [medline]
AID - 10.1111/j.1600-0838.2010.01195.x [doi]
PST - ppublish
SO  - Scand J Med Sci Sports. 2010 Oct;20 Suppl 2:103-11. doi:
      10.1111/j.1600-0838.2010.01195.x.


PMID- 20862708
OWN - NLM
STAT- MEDLINE
DCOM- 20110121
LR  - 20160401
IS  - 1522-726X (Electronic)
IS  - 1522-1946 (Linking)
VI  - 76
IP  - 4
DP  - 2010 Oct 1
TI  - Interventional cardiology live case presentations: regulatory considerations.
PG  - E126-9
LID - 10.1002/ccd.22718 [doi]
AB  - Live case presentations are increasingly common at interventional cardiology
      conferences. Taking advantage of significant advances in communication
      technology, broadcasts of procedures can be viewed as an extension of traditional
      medical education targeted to large groups of practitioners. However, there are
      important ethical, commercial, and patient safety issues associated with live
      cases that deserve attention. Use of investigational devices in live case
      demonstrations is subject to review and approval by FDA's Center for Devices and 
      Radiological Health (CDRH), and the outcomes of patients participating in live
      cases are considered in the overall clinical study results. This article
      discusses CDRH's regulatory view of live case presentations with a focus on
      patient safety, clinical trial integrity, and concerns regarding improper medical
      device promotion.
CI  - (c) 2010 Wiley-Liss, Inc.
FAU - Farb, Andrew
AU  - Farb A
AD  - Office of Device Evaluation, Center for Devices and Radiological Health, Food and
      Drug Administration, Silver Spring, Maryland 20993-0002, USA.
      andrew.farb@fda.hhs.gov
FAU - Brown, Sheila A
AU  - Brown SA
FAU - Wolf, Deborah A
AU  - Wolf DA
FAU - Zuckerman, Bram
AU  - Zuckerman B
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Catheter Cardiovasc Interv
JT  - Catheterization and cardiovascular interventions : official journal of the
      Society for Cardiac Angiography & Interventions
JID - 100884139
SB  - IM
CIN - Heart Rhythm. 2010 Oct;7(10):e1-3. PMID: 20869626
MH  - Cardiology/*legislation & jurisprudence/standards
MH  - Device Approval/*legislation & jurisprudence/*standards
MH  - Education, Medical/ethics/*legislation & jurisprudence/standards
MH  - Humans
MH  - Remote Consultation/*legislation & jurisprudence/*standards
MH  - Therapies, Investigational/standards
MH  - United States
EDAT- 2010/09/24 06:00
MHDA- 2011/01/22 06:00
CRDT- 2010/09/24 06:00
PHST- 2010/09/24 06:00 [entrez]
PHST- 2010/09/24 06:00 [pubmed]
PHST- 2011/01/22 06:00 [medline]
AID - 10.1002/ccd.22718 [doi]
PST - ppublish
SO  - Catheter Cardiovasc Interv. 2010 Oct 1;76(4):E126-9. doi: 10.1002/ccd.22718.


PMID- 20862294
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1937-5719 (Electronic)
IS  - 1937-5719 (Linking)
VI  - 10
DP  - 2010 Sep 15
TI  - Composite tissue transplantation: a new era in transplantation surgery.
LID - e58 [pii]
AB  - Once belonging to science fiction, face transplantation is a clinical reality
      now. The controversial first face transplantation in Amiens, France in 2005 was
      followed by significant ethical debate among physicians, surgeons, scientists and
      bioethicists. The controversies are being followed by cautious optimism and
      acceptance. An increasing number of surgical teams are developing protocols of
      composite tissue transplantation. Twenty five years after the birth of the
      American Society of Reconstructive Microsurgery (ASRM) and during its 25th
      anniversary, the founding meeting of American Society of Reconstructive
      Transplantation (ASRT) took place in 2009 to officially introduce the birth of a 
      new field that combines the two disciplines: transplantation and reconstructive
      microsurgery. It appears that the field of composite tissue allotransplantation
      will continue to grow for at least several years before more sophisticated means 
      of replacing the damaged tissues become available. This article takes a brief
      look at the evolution of organ transplantation and reflects our viewpoint
      regarding the emerging field of composite tissue allotransplantation (CTA).
FAU - Pomahac, Bohdan
AU  - Pomahac B
AD  - Division of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical
      School, Boston, Massachusetts.
FAU - Aflaki, Pejman
AU  - Aflaki P
LA  - eng
PT  - Journal Article
DEP - 20100915
PL  - United States
TA  - Eplasty
JT  - Eplasty
JID - 101316107
PMC - PMC2941187
EDAT- 2010/09/24 06:00
MHDA- 2010/09/24 06:01
CRDT- 2010/09/24 06:00
PHST- 2010/09/24 06:00 [entrez]
PHST- 2010/09/24 06:00 [pubmed]
PHST- 2010/09/24 06:01 [medline]
PST - epublish
SO  - Eplasty. 2010 Sep 15;10.


PMID- 20861205
OWN - NLM
STAT- MEDLINE
DCOM- 20110201
LR  - 20100923
IS  - 1477-111X (Electronic)
IS  - 0267-6591 (Linking)
VI  - 25
IP  - 5
DP  - 2010 Sep
TI  - Effect of increased pump flow on hepatic blood flow and systemic inflammatory
      response following on-pump coronary artery bypass grafting.
PG  - 293-303
LID - 10.1177/0267659110378843 [doi]
AB  - UNLABELLED: Reduced organ perfusion during cardiopulmonary bypass (CPB) is
      responsible for morbidity associated with cardiac surgery. Non-pulsatile flow and
      hypothermia during CPB have been shown to cause reduced perfusion. During CPB,
      cardiac output is directly proportional to the pump flow rate. Therefore, we
      hypothesised that increasing pump flow during hypothermic CPB would improve organ
      perfusion and reduce the inflammatory response in the post-operative period.
      METHODS: Ethics committee approval was obtained. Twelve consecutive patients with
      good or moderate left ventricular function undergoing elective or inpatient
      coronary artery bypass grafting were included in the study after obtaining
      informed consent. Patients were randomised to receive either normal flow or
      higher pump flow (20% more than the usual flow during hypothermia). Hepatic blood
      flow, cytokines such as interleukins 1beta, 6, 8, 10 and 12, tumour necrosis
      factor-alpha and complements C3a, C4a and C5a were measured during the
      peri-operative period. Data were analysed using SPSS (ver.15). Categorical data
      were compared using the chi-square test and trends in cytokines were compared
      using a repeated measures ANOVA test. RESULTS: Both the groups were similar in
      pre- and peri-operative variables. Hepatic blood flow almost doubled in the
      high-pump-flow group following an increase in the flow rate during
      hypothermia(p=0.026). The release of serum complement IL-6 and 8 appeared to be
      reduced in the high-flow group; however, the difference did not reach statistical
      significance. CONCLUSIONS: Higher pump flows during hypothermic CPB increase
      hepatic blood flow. There was a trend towards attenuation of post-operative
      inflammatory response; however, larger studies will be needed to confirm these
      findings.
FAU - Adluri, Rajeshwara Krishna Prasad
AU  - Adluri RK
AD  - Department of Cardiac Surgery, Trent Cardiac Centre, Nottingham City Hospital,
      Nottingham, UK. arkrishnap@yahoo.com
FAU - Singh, Arvind V
AU  - Singh AV
FAU - Skoyles, Julian
AU  - Skoyles J
FAU - Hitch, Tony
AU  - Hitch T
FAU - Robins, Adrian
AU  - Robins A
FAU - Baker, Mya
AU  - Baker M
FAU - Mitchell, Ian M
AU  - Mitchell IM
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - Perfusion
JT  - Perfusion
JID - 8700166
RN  - 0 (Cytokines)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9007-36-7 (Complement System Proteins)
SB  - IM
MH  - Complement System Proteins/analysis
MH  - Coronary Artery Bypass/*adverse effects/methods
MH  - Cytokines/blood
MH  - Heart-Assist Devices/*adverse effects
MH  - Inflammation/*etiology
MH  - Liver/*blood supply
MH  - Perioperative Period
MH  - *Regional Blood Flow
MH  - Tumor Necrosis Factor-alpha/blood
EDAT- 2010/09/24 06:00
MHDA- 2011/02/02 06:00
CRDT- 2010/09/24 06:00
PHST- 2010/09/24 06:00 [entrez]
PHST- 2010/09/24 06:00 [pubmed]
PHST- 2011/02/02 06:00 [medline]
AID - 25/5/293 [pii]
AID - 10.1177/0267659110378843 [doi]
PST - ppublish
SO  - Perfusion. 2010 Sep;25(5):293-303. doi: 10.1177/0267659110378843.


PMID- 20860879
OWN - NLM
STAT- MEDLINE
DCOM- 20110919
LR  - 20161020
IS  - 1469-5111 (Electronic)
IS  - 1461-1457 (Linking)
VI  - 14
IP  - 3
DP  - 2011 Apr
TI  - Ethical considerations in clinical training, care and research in
      psychopharmacology.
PG  - 413-24
LID - 10.1017/S1461145710001112 [doi]
AB  - Psychopharmacology is a powerful tool in psychiatry; however, it is one that
      demands responsibility in order to deal with the ethical complexities that
      accompany advances in the field. It is important that questions are asked and
      that ethical mindfulness and sensitivity are developed along with clinical
      skills. In order to cultivate and deepen ethical awareness and subsequently solve
      issues in optimal fashion, investment should be made in the development of an
      ethical decision-making process as well as in education in the ethics of
      psychopharmacology to trainees in the field at all stages of their educational
      development. A clear approach to identifying ethical problems, engaging various
      ethical concepts in considering solutions and then applying these principles in
      problem resolution is demanded. An openness in identifying and exploring issues
      has become crucial to the future development and maturation of
      psychopharmacologists, both research and clinical. Consideration must be given to
      the social implications of psychopharmacological practice, with the best
      interests of patients always paramount. From both a research and clinical
      perspective, psychopharmacology has to be practised with fairness, sensitivity
      and ethical relevance to all. While ethical issues related to
      psychopharmacological practice are varied and plentiful, this review focuses on
      advances in technology and biological sciences, personal integrity, special
      populations, and education and training.
FAU - Strous, Rael D
AU  - Strous RD
AD  - Beer Yaakov Mental Health Center, Beer Yaakov, Israel. raels@post.tau.ac.il
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100922
PL  - England
TA  - Int J Neuropsychopharmacol
JT  - The international journal of neuropsychopharmacology
JID - 9815893
SB  - IM
MH  - Ethics, Research/*education
MH  - Humans
MH  - Pharmacogenetics/economics/*ethics
MH  - Psychiatry/*education/*ethics/trends
MH  - Psychopharmacology/*education/*ethics/trends
MH  - Research/education
MH  - Vulnerable Populations
EDAT- 2010/09/24 06:00
MHDA- 2011/09/20 06:00
CRDT- 2010/09/24 06:00
PHST- 2010/09/24 06:00 [entrez]
PHST- 2010/09/24 06:00 [pubmed]
PHST- 2011/09/20 06:00 [medline]
AID - S1461145710001112 [pii]
AID - 10.1017/S1461145710001112 [doi]
PST - ppublish
SO  - Int J Neuropsychopharmacol. 2011 Apr;14(3):413-24. doi:
      10.1017/S1461145710001112. Epub 2010 Sep 22.


PMID- 20860657
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20211020
IS  - 1476-5381 (Electronic)
IS  - 0007-1188 (Linking)
VI  - 161
IP  - 4
DP  - 2010 Oct
TI  - Refinement, reduction and replacement approaches to in vivo cardiovascular
      research.
PG  - 749-54
LID - 10.1111/j.1476-5381.2010.00959.x [doi]
AB  - In this review, the justification and benefits of refinement, reduction and
      replacement (3Rs) approaches to cardiovascular research are examined using the
      field of platelet biology and arterial thrombosis as an example. Arterial
      thrombosis is a platelet-driven condition and platelets are regulated by
      autologous signals, but also by external factors such as the vascular
      endothelium. In vitro assays using isolated platelets therefore poorly reflect in
      vivo platelet function and human disease. As a consequence, animal models,
      including mouse models, are frequently used. In particular, models of
      thromboembolic mortality have been successfully employed to determine the role of
      the vascular endothelium in regulating platelet function and thrombosis in vivo. 
      Such models raise both scientific and ethical concerns and have recently been
      refined permitting the use of fewer mice at a lower severity level. These
      refinements have been scientifically beneficial in permitting analysis of the
      development and progression of thrombotic diseases and in improving our
      understanding of the role of the vascular endothelium in regulating platelet
      function and thrombosis. For many, the ultimate goal in 3Rs-driven science is
      replacement of animal models with non-animal alternatives; this is exemplified,
      in the platelet field, by the development of in vitro flow systems. The
      development of 3Rs approaches to cardiovascular research is shown to have led to 
      improved scientific models. Further characterization and use of these models will
      likely contribute to increased understanding of thrombotic disease processes and 
      facilitate drug development in the cardiovascular field.
CI  - (c) 2010 The Author. British Journal of Pharmacology (c) 2010 The British
      Pharmacological Society.
FAU - Emerson, Michael
AU  - Emerson M
AD  - National Heart and Lung Institute, Imperial College London, London, UK.
      m.emerson@imperial.ac.uk
LA  - eng
GR  - G0900732/1/NC3RS_/National Centre for the Replacement, Refinement and Reduction
      of Animals in Research/United Kingdom
GR  - WT_/Wellcome Trust/United Kingdom
GR  - BHF_/British Heart Foundation/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Br J Pharmacol
JT  - British journal of pharmacology
JID - 7502536
SB  - IM
MH  - Animal Testing Alternatives
MH  - Animals
MH  - Blood Platelets/*metabolism
MH  - Cardiovascular Diseases/*physiopathology
MH  - Disease Models, Animal
MH  - Endothelium, Vascular/metabolism
MH  - Ethics, Research
MH  - Humans
MH  - Mice
MH  - Research Design
MH  - Thromboembolism/mortality/physiopathology
MH  - Thrombosis/*physiopathology
PMC - PMC2992891
EDAT- 2010/09/24 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/09/24 06:00
PHST- 2010/09/24 06:00 [entrez]
PHST- 2010/09/24 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1111/j.1476-5381.2010.00959.x [doi]
PST - ppublish
SO  - Br J Pharmacol. 2010 Oct;161(4):749-54. doi: 10.1111/j.1476-5381.2010.00959.x.


PMID- 20860263
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20101109
LR  - 20100923
IS  - 0097-9805 (Print)
IS  - 0097-9805 (Linking)
VI  - 36
IP  - 4
DP  - 2010 Jul-Aug
TI  - Good is not good enough: the culture of low expectations and the leader's
      challenge.
PG  - 216-7
AB  - There are many examples of health care organizations that have morphed from the
      culture of low expectation to the culture of excellence. Ethically, to not drive 
      to excellence means that we are settling from knowingly allowing harm to happen
      on our watch. The leader's obligation is to create that sonic boom that Black and
      Gregersen (2008) describe to break up the old mind maps, to create the movement, 
      and to finish the cultural change in spite of change fatigue and other factors
      that could sabotage the process. Only then can the effective leader sleep well at
      night knowing that the infrastructure is being created that will provide a
      culture of excellence and safety for patients and their families. And it is being
      created on his/her watch.
FAU - Kerfoot, Karlene M
AU  - Kerfoot KM
AD  - Aurora Health System, Milwaukee, WI, USA. karlene.kerfoot@aurora.org
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pediatr Nurs
JT  - Pediatric nursing
JID - 7505804
EDAT- 2010/09/24 06:00
MHDA- 2010/09/24 06:01
CRDT- 2010/09/24 06:00
PHST- 2010/09/24 06:00 [entrez]
PHST- 2010/09/24 06:00 [pubmed]
PHST- 2010/09/24 06:01 [medline]
PST - ppublish
SO  - Pediatr Nurs. 2010 Jul-Aug;36(4):216-7.


PMID- 20859849
OWN - NLM
STAT- MEDLINE
DCOM- 20120208
LR  - 20181201
IS  - 1439-4421 (Electronic)
IS  - 0941-3790 (Linking)
VI  - 73
IP  - 7
DP  - 2011 Jul
TI  - [Shared decision making (SDM): a systematic survey of terminology use and
      concepts].
PG  - 399-408
LID - 10.1055/s-0030-1262870 [doi]
AB  - Shared decision making (SDM) has been investigated in numerous research projects.
      In 2001 the German Ministry of Health initiated a research program on patients as
      partners in medical decision making ("Der Patient als Partner im medizinischen
      Entscheidungsprozess"). In this context a large number of studies has been
      conducted on SDM. In this review the concept of SDM and the use of this term in
      scientific publications of German study groups is explored. A systematic
      literature review generated 147 publications on SDM by German researchers, which 
      had been published between 2000 and 2009. The majority of publications identified
      in this study refer to clinical studies on patients with chronic diseases.
      Content analysis of the retrieved publications indicates that SDM as a term is
      used heterogeneously. There is only little research on the theoretical
      foundations and ethical implications of SDM. In addition to existent Anglo-Saxon 
      definitions of SDM, new concepts of SDM such as involvement of relatives in the
      process of decision making were identified as part of this review of the German
      literature. There is only a limited number of empirical studies with a consistent
      approach towards a definition of SDM and the respective measurements. Against
      this background, the "SDM questionnaire", which had been developed as part of the
      German Ministry of Health's research programme, is an important contribution with
      respect to operationalising SDM and testing possible effects of SDM in clinical
      practice.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Rockenbauch, K
AU  - Rockenbauch K
AD  - Universitatsklinikum Leipzig, Selbststandige Abteilung fur Medizinische
      Psychologie und Medizinische Soziologie, Philipp-Rosenthal-Strasse 55, Leipzig.
      Katrin.Rockenbauch@medizin.uni-leipzig.de
FAU - Schildmann, J
AU  - Schildmann J
LA  - ger
PT  - Journal Article
PT  - Review
PT  - Systematic Review
TT  - Partizipative Entscheidungsfindung (PEF): eine systematische Ubersichtsarbeit zu 
      Begriffsverwendung und Konzeptionen.
DEP - 20100921
PL  - Germany
TA  - Gesundheitswesen
JT  - Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes
      (Germany))
JID - 9204210
SB  - IM
MH  - Chronic Disease/*therapy
MH  - *Decision Making/ethics
MH  - Ethics, Medical
MH  - Germany
MH  - Health Services Research/ethics
MH  - Humans
MH  - *National Health Programs/ethics
MH  - Physician-Patient Relations/ethics
MH  - Surveys and Questionnaires
MH  - Terminology as Topic
EDAT- 2010/09/23 06:00
MHDA- 2012/02/09 06:00
CRDT- 2010/09/23 06:00
PHST- 2010/09/23 06:00 [entrez]
PHST- 2010/09/23 06:00 [pubmed]
PHST- 2012/02/09 06:00 [medline]
AID - 10.1055/s-0030-1262870 [doi]
PST - ppublish
SO  - Gesundheitswesen. 2011 Jul;73(7):399-408. doi: 10.1055/s-0030-1262870. Epub 2010 
      Sep 21.


PMID- 20859319
OWN - NLM
STAT- MEDLINE
DCOM- 20110103
LR  - 20131121
IS  - 2150-1149 (Electronic)
IS  - 1533-3159 (Linking)
VI  - 13
IP  - 5
DP  - 2010 Sep-Oct
TI  - Clinical and histological effects of the intrathecal administration of
      methylprednisolone in dogs.
PG  - 493-501
AB  - BACKGROUND: Methylprednisolone is one of the most commonly used steroids for
      management of chronic back pain via epidural injection. Its inadvertent injection
      into the intrathecal space is associated with complications such as adhesive
      arachnoiditis. OBJECTIVE: The present study aimed to assess the clinical and
      histological changes associated with the injection of methylprednisolone into the
      intrathecal space of dogs. STUDY DESIGN: A randomized, double blind, controlled
      animal trial. METHODS: After approval by the animal research ethics committee, 14
      dogs were studied in a randomized double blind controlled trial. They were
      assigned to one of 2 groups: Group I received 1 mL of 0.9% normal saline; Group
      II received 1 mL (1.15mg/kg) of methylprednisolone into the intrathecal space.
      Animals were clinically evaluated for 21 days, and then sacrificed. The lumbar
      and sacral portions of their spinal cords were removed for histological
      examination. RESULTS: In Group I, there were no clinical or histological changes.
      All animals in Group II showed no clinical changes but all exhibited histological
      changes in the spinal cord. The main histological changes consisted of meningeal 
      thickening and lymphocytic infiltrates in the blood vessels. In 3 animals,
      adhesion of pia, arachnoid, and dura matter was noted and the nerve roots were
      surrounded by fibrosis. In one animal, necrosis of the spinal cord was evident.
      LIMITATIONS: The limitations of the present study include: small sample of
      animals (n=14), relative short clinical follow-up (21 days), and use of a
      commercially available drug solution, which is not preservative free. CONCLUSION:
      The present study demonstrated that the intrathecal administration of
      commercially available methylprednisolone was responsible for causing
      histological changes in the spinal cord and meninges of the animals studied.
FAU - Lima, Rodrigo Moreira
AU  - Lima RM
AD  - Sao Paulo State University Botucatu, Sao Paulo. rmelima@gmail.com
FAU - Navarro, Lais H
AU  - Navarro LH
FAU - Carness, Jeffrey M
AU  - Carness JM
FAU - Barros, Guilherme A
AU  - Barros GA
FAU - Marques, Mariangela E A
AU  - Marques ME
FAU - Solanki, Daneshvari
AU  - Solanki D
FAU - Ganem, Eliana M
AU  - Ganem EM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pain Physician
JT  - Pain physician
JID - 100954394
RN  - 0 (Anti-Inflammatory Agents)
RN  - X4W7ZR7023 (Methylprednisolone)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/administration & dosage/*adverse effects
MH  - Back Pain/drug therapy
MH  - Dogs
MH  - Injections, Spinal/*adverse effects
MH  - Meninges/drug effects/*pathology
MH  - Methylprednisolone/administration & dosage/*adverse effects
MH  - Spinal Cord/*drug effects/pathology
MH  - Tissue Adhesions/chemically induced
EDAT- 2010/09/23 06:00
MHDA- 2011/01/05 06:00
CRDT- 2010/09/23 06:00
PHST- 2010/09/23 06:00 [entrez]
PHST- 2010/09/23 06:00 [pubmed]
PHST- 2011/01/05 06:00 [medline]
PST - ppublish
SO  - Pain Physician. 2010 Sep-Oct;13(5):493-501.


PMID- 20858850
OWN - NLM
STAT- MEDLINE
DCOM- 20110110
LR  - 20181201
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 257
IP  - 3
DP  - 2010 Dec
TI  - Primary human breast adenocarcinoma: imaging and histologic correlates of
      intrinsic susceptibility-weighted MR imaging before and during chemotherapy.
PG  - 643-52
LID - 10.1148/radiol.10100421 [doi]
AB  - PURPOSE: To investigate the histopathologic and dynamic magnetic resonance (MR)
      imaging correlates of intrinsic susceptibility-weighted (ISW) MR imaging in
      patients with primary human breast adenocarcinoma and to assess the relationship 
      between baseline transverse relaxation rate (R2*) and T2* relaxivity change
      (DeltaR2*) and the response to neoadjuvant chemotherapy (NAC). MATERIALS AND
      METHODS: Institutional ethics approval and informed consent were obtained.
      Between September 2001 and January 2008, 83 women (median age, 46 years; age
      range, 26-72 years) with breast cancer were recruited to undergo dynamic contrast
      medium-enhanced (DCE), dynamic susceptibility contrast-enhanced (DSC), and ISW MR
      imaging before and after two cycles of NAC. After excluding necrotic,
      infiltrating, and invasive lobular carcinomas, 31 patients were available for
      baseline assessment and 27 were available for response assessment. Transfer
      constant, leakage space, rate constant, initial area under the gadolinium
      concentration-time curve at 60 seconds, relative blood volume (rBV), relative
      blood flow (rBF), and R2* were calculated. Relationships between baseline R2* and
      histopathologic variables (tumor grade, estrogen receptor status, progesterone
      receptor status, human epidermal growth factor 2 status), tumor size, and dynamic
      MR imaging parameters were sought. Baseline adenocarcinoma R2* (n = 31) and
      DeltaR2* (n = 27) were correlated with final pathologic response. RESULTS:
      Inverse correlations between baseline R2* and rBV (rho = -0.48, P = .013) and rBF
      (rho = -0.44, P = .024) were found, but not after NAC. No relationships were
      observed between baseline R2* and other kinetic imaging parameters,
      histopathologic characteristics, or tumor size (P > .05). Baseline R2* values
      were lower in tumors than in normal breast tissue (31.8 sec(-1) vs 36.2 sec(-1), 
      P = .017) but not after NAC. Increases in R2* were observed after treatment (31.1
      sec(-1) vs 34.8 sec(-1), P = .006), with larger increases correlating with
      pathologic response. DeltaR2* was not as effective as DCE or DSC MR imaging
      parameters in the prediction of response. CONCLUSION: R2* is influenced by blood 
      volume in untreated breast adenocarcinomas. Increases in R2* after two cycles of 
      NAC correlate with pathologic response. Therapy-induced uncoupling of the
      relationship between R2* and rBV and rBF is consistent with responding tumors
      becoming hypoxic early during treatment. SUPPLEMENTAL MATERIAL:
      http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.10100421/-/DC1.
CI  - (c) RSNA, 2010
FAU - Li, Sonia P
AU  - Li SP
AD  - Academic Oncology Unit, Mount Vernon Cancer Centre, Rickmansworth Rd, Northwood, 
      Middlesex HA6 2RN, England. soniali@gmail.com
FAU - Taylor, N Jane
AU  - Taylor NJ
FAU - Makris, Andreas
AU  - Makris A
FAU - Ah-See, Mei-Lin W
AU  - Ah-See ML
FAU - Beresford, Mark J
AU  - Beresford MJ
FAU - Stirling, J James
AU  - Stirling JJ
FAU - d'Arcy, James A
AU  - d'Arcy JA
FAU - Collins, David J
AU  - Collins DJ
FAU - Padhani, Anwar R
AU  - Padhani AR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100921
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Contrast Media)
RN  - 0 (Taxoids)
RN  - 15H5577CQD (Docetaxel)
RN  - 3Z8479ZZ5X (Epirubicin)
RN  - 8N3DW7272P (Cyclophosphamide)
RN  - U3P01618RT (Fluorouracil)
SB  - IM
MH  - Adenocarcinoma/*drug therapy/*pathology
MH  - Adult
MH  - Aged
MH  - Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
MH  - Biomarkers, Tumor/analysis
MH  - Biopsy
MH  - Breast Neoplasms/*drug therapy/*pathology
MH  - Contrast Media
MH  - Cyclophosphamide/administration & dosage
MH  - Docetaxel
MH  - Epirubicin/administration & dosage
MH  - Female
MH  - Fluorouracil/administration & dosage
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - In Situ Hybridization, Fluorescence
MH  - Magnetic Resonance Imaging/*methods
MH  - Middle Aged
MH  - Neoadjuvant Therapy
MH  - Neoplasm Invasiveness/pathology
MH  - Neoplasm Staging
MH  - Neoplasm, Residual/pathology
MH  - Prospective Studies
MH  - ROC Curve
MH  - Statistics, Nonparametric
MH  - Taxoids/administration & dosage
EDAT- 2010/09/23 06:00
MHDA- 2011/01/11 06:00
CRDT- 2010/09/23 06:00
PHST- 2010/09/23 06:00 [entrez]
PHST- 2010/09/23 06:00 [pubmed]
PHST- 2011/01/11 06:00 [medline]
AID - radiol.10100421 [pii]
AID - 10.1148/radiol.10100421 [doi]
PST - ppublish
SO  - Radiology. 2010 Dec;257(3):643-52. doi: 10.1148/radiol.10100421. Epub 2010 Sep
      21.


PMID- 20858701
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20191210
IS  - 1468-4373 (Electronic)
IS  - 0022-5045 (Linking)
VI  - 66
IP  - 4
DP  - 2011 Oct
TI  - What's in a name? Generics and the persistence of the pharmaceutical brand in
      American medicine.
PG  - 468-506
LID - 10.1093/jhmas/jrq049 [doi]
AB  - This paper explores the complex role that brand names have played in the
      maintenance of therapeutic standards within twentieth-century American medicine. 
      What made a generic drug generic in the second half of the twentieth century--and
      by extension, what made a nonproprietary drug not proprietary in the first
      half--was dependent on changing drug branding practices and evolving standards of
      evidence attached to claims of therapeutic efficacy and safety. This article maps
      three eras of shifting oppositions between branded and unbranded pharmaceuticals.
      First, an era of "ethical marketing," extending from before the Pure Food and
      Drug Act of 1906 into roughly the 1930s, which pitted nonproprietary or "ethical"
      pharmaceuticals against proprietary or patent medicines; second, an era of
      ascendant brand-name prescribing from the 1930s until roughly the 1960s, as
      manufacturers of innovative and patent-protected "specialty" drugs depicted
      generic production as a form of counterfeiting; and finally, an era of generic
      backlash from the 1960s onwards, which assumed the interchangeability of branded 
      and generic drugs. This article uses clinical, popular, policy, and trade
      literatures to explore the enduring roles of brand-logic in the face of generic
      competition in the American drug market.
FAU - Greene, Jeremy A
AU  - Greene JA
AD  - History of Science Department, Harvard University, Science Center 364, One Oxford
      Street, Cambridge, Massachusetts 02138, USA. justin.barr@yale.edu
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100921
PL  - England
TA  - J Hist Med Allied Sci
JT  - Journal of the history of medicine and allied sciences
JID - 0413415
RN  - 0 (Drugs, Generic)
RN  - 0 (Nonprescription Drugs)
SB  - IM
MH  - Advertising/history
MH  - Drug Industry/*history
MH  - Drugs, Generic/*history
MH  - History, 20th Century
MH  - Humans
MH  - Nonprescription Drugs/history
MH  - Patents as Topic/history
MH  - Pharmacopoeias as Topic/history
MH  - Terminology as Topic
MH  - Therapeutic Equivalency
MH  - United States
EDAT- 2010/09/23 06:00
MHDA- 2012/01/27 06:00
CRDT- 2010/09/23 06:00
PHST- 2010/09/23 06:00 [entrez]
PHST- 2010/09/23 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - jrq049 [pii]
AID - 10.1093/jhmas/jrq049 [doi]
PST - ppublish
SO  - J Hist Med Allied Sci. 2011 Oct;66(4):468-506. doi: 10.1093/jhmas/jrq049. Epub
      2010 Sep 21.


PMID- 20857704
OWN - NLM
STAT- MEDLINE
DCOM- 20101102
LR  - 20150826
IS  - 0370-629X (Print)
IS  - 0370-629X (Linking)
VI  - 65
IP  - 7-8
DP  - 2010 Jul-Aug
TI  - [Critical reflections concerning euthanasia for persons with dementia].
PG  - 453-8
AB  - In the public debate on the extension of euthanasia for people with dementia, in 
      addition to ethical considerations and arguments, other issues have to be kept in
      mind. The diagnosis of dementia is difficult and the clinical picture is very
      fluctuating. The assessment and especially the operationalization of legal
      capacity and the use of advance directives are complex problems. The discussion
      should be conducted against the backdrop of a cultural framework in which the
      interpretation and development of palliative care is crucial. The development of 
      a framework like advance care planning creates opportunities. The question
      remains whether the legal issues can be clarified and whether a legal approach
      generates solutions for the problems described.
FAU - De Lepeleire, J
AU  - De Lepeleire J
AD  - Academisch Centrum Huisartsgeneeskunde, K. U. Leuven, Leuven, Belgium.
      jan.delepeleire@med.kuleuven.be
FAU - Beyen, A
AU  - Beyen A
FAU - Burin, M
AU  - Burin M
FAU - Fabri, R
AU  - Fabri R
FAU - Ghijsebrechts, G
AU  - Ghijsebrechts G
FAU - Lisaerde, J
AU  - Lisaerde J
FAU - Temmerman, B
AU  - Temmerman B
FAU - Van den Eynden, B
AU  - Van den Eynden B
FAU - Van den Noortgate, N
AU  - Van den Noortgate N
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Reflexions critiques a propos de l'euthanasie de personnes atteintes de demence.
PL  - Belgium
TA  - Rev Med Liege
JT  - Revue medicale de Liege
JID - 0404317
SB  - IM
MH  - Advance Care Planning
MH  - Culture
MH  - Dementia/*complications
MH  - Euthanasia/*ethics
MH  - Humans
MH  - Palliative Care
MH  - Personal Autonomy
MH  - Societies, Medical
EDAT- 2010/09/23 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/09/23 06:00
PHST- 2010/09/23 06:00 [entrez]
PHST- 2010/09/23 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
PST - ppublish
SO  - Rev Med Liege. 2010 Jul-Aug;65(7-8):453-8.


PMID- 20857672
OWN - NLM
STAT- MEDLINE
DCOM- 20101109
LR  - 20100922
IS  - 0021-4892 (Print)
IS  - 0021-4892 (Linking)
VI  - 59
IP  - 9
DP  - 2010 Sep
TI  - [Jehovah's Witness patients].
PG  - 1149-52
AB  - There are still legal and ethical problems relating to the refusal of blood
      transfusion due to religious belief of Jehovah's Witness patients. Since general 
      consensus about the anesthetic management of these patients has not been
      established, the "Guidelines for refusal of blood transfusion on religious
      grounds" was proposed by the joint committee including Japanese Society of
      Anesthesiologists in February 2008. The principle of the guideline is that if a
      patient, who refuses blood transfusion even at cost of life, is 18 years old or
      above and competent to understand the medical treatment and the adverse effects
      due to bloodless medicine, doctors may plan and complete bloodless surgery. The
      same policy is allowed if the patient is 15 years old or above and he/she as well
      as all the parental authorities refuse blood transfusion. In other cases, the
      policy of life-saving blood transfusion should be explained to the patients. If a
      bloodless surgery is planned, precise perioperative strategies to avoid blood
      loss have to be carried out with the cooperation of all the physicians who care
      the patient. Anesthesiologists should be carefully prepared for the possible law 
      suits that might lead to unexpected outcomes.
FAU - Yorozu, Tomoko
AU  - Yorozu T
AD  - Department of Anesthesiology, Kyorin University, Faculty of Medicine, Tokyo
      181-8611.
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Masui
JT  - Masui. The Japanese journal of anesthesiology
JID - 0413707
SB  - IM
MH  - Adolescent
MH  - *Blood Transfusion
MH  - Humans
MH  - *Jehovah's Witnesses
MH  - Practice Guidelines as Topic
EDAT- 2010/09/23 06:00
MHDA- 2010/11/10 06:00
CRDT- 2010/09/23 06:00
PHST- 2010/09/23 06:00 [entrez]
PHST- 2010/09/23 06:00 [pubmed]
PHST- 2010/11/10 06:00 [medline]
PST - ppublish
SO  - Masui. 2010 Sep;59(9):1149-52.


PMID- 20857600
OWN - HMD
STAT- MEDLINE
DCOM- 20101230
LR  - 20191027
IS  - 0034-6764 (Print)
IS  - 0034-6764 (Linking)
VI  - 68
IP  - 3
DP  - 2010
TI  - An economic and ethical approach to charity and to charity endowments.
PG  - 261-84
AB  - We examine how and why donors divide gifts between people in the present (across 
      distance) and between the present and future (across time). US donors tend to
      give less to charities that benefit the poor and more to charities that benefit
      the non-poor (such as museums, universities, and arts organizations). Many of
      these wealthier charities have created endowments that benefit not only present
      persons, but also future persons. We develop a shorthand framework for linking
      time to distance in charitable allocations that incorporates a "proximity
      preference," i.e., charity that prefers those who are nearer to us whether by
      reason of physical distance, psychic-identity, or temporal distance. Even though 
      ethical considerations suggest that recipients' level of need should be the
      dominant factor in allocating gifts, donors also express preferences, ceteris
      paribus, for benefits arriving sooner rather than later, and for recipients who
      are ''closer'' rather than farther away.
FAU - Core, John E
AU  - Core JE
AD  - Wharton School, University of Pennsylvania.
FAU - Donaldson, Thomas
AU  - Donaldson T
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - Rev Soc Econ
JT  - Review of social economy
JID - 100970064
MH  - *Charities/economics/education/history/legislation & jurisprudence
MH  - Economics/history
MH  - Financial Management/economics/history
MH  - *Fund Raising/economics/history
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Population Groups/education/ethnology/history/psychology
MH  - *Public Assistance/economics/history
MH  - *Social Welfare/economics/ethnology/history/psychology
MH  - Socioeconomic Factors/history
MH  - *Voluntary Programs/economics/history
MH  - Volunteers/education/history/psychology
EDAT- 2010/09/23 06:00
MHDA- 2010/12/31 06:00
CRDT- 2010/09/23 06:00
PHST- 2010/09/23 06:00 [entrez]
PHST- 2010/09/23 06:00 [pubmed]
PHST- 2010/12/31 06:00 [medline]
AID - 10.1080/00346760903480517 [doi]
PST - ppublish
SO  - Rev Soc Econ. 2010;68(3):261-84. doi: 10.1080/00346760903480517.


PMID- 20857022
OWN - NLM
STAT- MEDLINE
DCOM- 20110228
LR  - 20190608
IS  - 1680-5348 (Electronic)
IS  - 1020-4989 (Linking)
VI  - 28
IP  - 1
DP  - 2010 Jul
TI  - [Ethics and eHealth: reflections for a safe practice].
PG  - 58-65
LID - S1020-49892010000700009 [pii]
AB  - The term eHealth (or telemedicine, telehealth) has been used to describe
      activities that employ information and telecommunication technologies to deliver 
      health care. Distance is an important factor hindering the delivery of many
      important services, such as diagnosis, treatment, prevention, health promotion,
      and health research assessment. Although eHealth can provide interesting
      solutions such as a second specialist opinion in geographically isolated areas, a
      large number of ethical and legal issues must be considered. It is essential to
      discuss, among others, aspects relating to safety and confidentiality;
      professional accountability; technical standards relating to digital recording,
      storage, and transmission of clinical data; copyright; authorization from
      professional regulatory bodies; and licensing for the remote practice of
      medicine. In Brazil, the Federal Council of Medicine has already established
      rules for telemedicine; however, it is still necessary to further this discussion
      to involve the entire health care sector. Since there are many eHealth projects
      being developed in Brazil, there is an urgent need to design protocols and
      training programs for all professionals involved.
FAU - Rezende, Edson Jose Carpintero
AU  - Rezende EJ
AD  - Universidade do Estado de Minas Gerais (UEMG). edson.carpintero@gmail.com
FAU - Melo, Maria do Carmo Barros de
AU  - Melo Mdo C
FAU - Tavares, Eduardo Carlos
AU  - Tavares EC
FAU - Santos, Alaneir de Fatima dos
AU  - Santos Ade F
FAU - Souza, Claudio de
AU  - Souza Cd
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Etica e telessaude: reflexoes para uma pratica segura.
PL  - United States
TA  - Rev Panam Salud Publica
JT  - Revista panamericana de salud publica = Pan American journal of public health
JID - 9705400
SB  - IM
MH  - Brazil
MH  - Humans
MH  - Telemedicine/*ethics/standards
EDAT- 2010/09/22 06:00
MHDA- 2011/03/01 06:00
CRDT- 2010/09/22 06:00
PHST- 2009/04/13 00:00 [received]
PHST- 2009/08/21 00:00 [accepted]
PHST- 2010/09/22 06:00 [entrez]
PHST- 2010/09/22 06:00 [pubmed]
PHST- 2011/03/01 06:00 [medline]
AID - S1020-49892010000700009 [pii]
AID - 10.1590/s1020-49892010000700009 [doi]
PST - ppublish
SO  - Rev Panam Salud Publica. 2010 Jul;28(1):58-65. doi:
      10.1590/s1020-49892010000700009.


PMID- 20856807
OWN - NLM
STAT- MEDLINE
DCOM- 20110218
LR  - 20220316
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 5
IP  - 9
DP  - 2010 Sep 15
TI  - Systematic characterizations of text similarity in full text biomedical
      publications.
PG  - e12704
LID - 10.1371/journal.pone.0012704 [doi]
LID - e12704 [pii]
AB  - BACKGROUND: Computational methods have been used to find duplicate biomedical
      publications in MEDLINE. Full text articles are becoming increasingly available, 
      yet the similarities among them have not been systematically studied. Here, we
      quantitatively investigated the full text similarity of biomedical publications
      in PubMed Central. METHODOLOGY/PRINCIPAL FINDINGS: 72,011 full text articles from
      PubMed Central (PMC) were parsed to generate three different datasets: full
      texts, sections, and paragraphs. Text similarity comparisons were performed on
      these datasets using the text similarity algorithm eTBLAST. We measured the
      frequency of similar text pairs and compared it among different datasets. We
      found that high abstract similarity can be used to predict high full text
      similarity with a specificity of 20.1% (95% CI [17.3%, 23.1%]) and sensitivity of
      99.999%. Abstract similarity and full text similarity have a moderate correlation
      (Pearson correlation coefficient: -0.423) when the similarity ratio is above 0.4.
      Among pairs of articles in PMC, method sections are found to be the most
      repetitive (frequency of similar pairs, methods: 0.029, introduction: 0.0076,
      results: 0.0043). In contrast, among a set of manually verified duplicate
      articles, results are the most repetitive sections (frequency of similar pairs,
      results: 0.94, methods: 0.89, introduction: 0.82). Repetition of introduction and
      methods sections is more likely to be committed by the same authors (odds of a
      highly similar pair having at least one shared author, introduction: 2.31,
      methods: 1.83, results: 1.03). There is also significantly more similarity in
      pairs of review articles than in pairs containing one review and one nonreview
      paper (frequency of similar pairs: 0.0167 and 0.0023, respectively).
      CONCLUSION/SIGNIFICANCE: While quantifying abstract similarity is an effective
      approach for finding duplicate citations, a comprehensive full text analysis is
      necessary to uncover all potential duplicate citations in the scientific
      literature and is helpful when establishing ethical guidelines for scientific
      publications.
FAU - Sun, Zhaohui
AU  - Sun Z
AD  - Virginia Bioinformatics Institute, Blacksburg, Virginia, United States of
      America.
FAU - Errami, Mounir
AU  - Errami M
FAU - Long, Tara
AU  - Long T
FAU - Renard, Chris
AU  - Renard C
FAU - Choradia, Nishant
AU  - Choradia N
FAU - Garner, Harold
AU  - Garner H
LA  - eng
GR  - R01 LM009758/LM/NLM NIH HHS/United States
GR  - R01 LM009758-01/LM/NLM NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20100915
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Abstracting and Indexing
MH  - Algorithms
MH  - Biomedical Research
MH  - *MEDLINE
MH  - *Periodicals as Topic
MH  - Software
MH  - United States
PMC - PMC2939881
EDAT- 2010/09/22 06:00
MHDA- 2011/02/22 06:00
CRDT- 2010/09/22 06:00
PHST- 2010/05/28 00:00 [received]
PHST- 2010/08/21 00:00 [accepted]
PHST- 2010/09/22 06:00 [entrez]
PHST- 2010/09/22 06:00 [pubmed]
PHST- 2011/02/22 06:00 [medline]
AID - 10.1371/journal.pone.0012704 [doi]
PST - epublish
SO  - PLoS One. 2010 Sep 15;5(9):e12704. doi: 10.1371/journal.pone.0012704.


PMID- 20856693
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 1479-6708 (Print)
IS  - 1479-6708 (Linking)
VI  - 5
IP  - 4
DP  - 2010 Jul 1
TI  - Estimating and disclosing the risk of developing Alzheimer's disease: challenges,
      controversies and future directions.
PG  - 501-517
AB  - With Alzheimer's disease increasing in prevalence and public awareness, more
      people are becoming interested in learning their chances of developing this
      condition. Disclosing Alzheimer's disease risk has been discouraged because of
      the limited predictive value of available tests, lack of prevention and treatment
      options, and concerns regarding potential psychological and social harms.
      However, challenges to this status quo include the availability of
      direct-to-consumer health risk information (e.g., genetic susceptibility tests), 
      as well as a growing literature suggesting that people seeking risk information
      for Alzheimer's disease through formal education and counseling protocols
      generally find it useful and do not experience adverse effects. This paper
      reviews current and potential methods of risk assessment for Alzheimer's disease,
      discusses the process and impact of disclosing risk to interested patients and
      consumers, and considers the practical and ethical challenges in this emerging
      area. Anticipated future directions are addressed.
FAU - Roberts, J Scott
AU  - Roberts JS
AD  - Department of Health Behavior & Health Education, University of Michigan School
      of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109, USA.
FAU - Tersegno, Sarah M
AU  - Tersegno SM
LA  - eng
GR  - R01 HG002213/HG/NHGRI NIH HHS/United States
GR  - R01 HG002213-09/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PL  - England
TA  - Future Neurol
JT  - Future neurology
JID - 101278119
PMC - PMC2941213
MID - NIHMS226929
EDAT- 2010/09/22 06:00
MHDA- 2010/09/22 06:01
CRDT- 2010/09/22 06:00
PHST- 2010/09/22 06:00 [entrez]
PHST- 2010/09/22 06:00 [pubmed]
PHST- 2010/09/22 06:01 [medline]
AID - 10.2217/fnl.10.31 [doi]
PST - ppublish
SO  - Future Neurol. 2010 Jul 1;5(4):501-517. doi: 10.2217/fnl.10.31.


PMID- 20856245
OWN - NLM
STAT- MEDLINE
DCOM- 20101020
LR  - 20100921
IS  - 1532-6535 (Electronic)
IS  - 0009-9236 (Linking)
VI  - 88
IP  - 4
DP  - 2010 Oct
TI  - Efficacy, safety, and ethics of cosmetic neurology far from settled.
PG  - 461-3
LID - 10.1038/clpt.2010.194 [doi]
AB  - In this issue, Larriviere and colleagues discuss the emerging use of drugs to
      enhance cognitive function. Several cautions they raise warrant amplification.
      People have tried to pharmacologically improve cognitive function for millennia, 
      but Larriviere and colleagues postulate that new, more effective drugs will lead 
      to the emergence of "cosmetic neurology." The ethics of using drugs to improve
      performance, as opposed to treating disease or restoring normal function, are far
      from settled.
FAU - Flower, K
AU  - Flower K
AD  - Addiction & Pharmacology Research Laboratory, California Pacific Medical Center
      Research Institute, St Luke's Hospital, San Francisco, California, USA.
FAU - Li, L
AU  - Li L
FAU - Chen, C-Y A
AU  - Chen CY
FAU - Baggott, M J
AU  - Baggott MJ
FAU - Galloway, G P
AU  - Galloway GP
FAU - Mendelson, J
AU  - Mendelson J
LA  - eng
GR  - P50 DA018179/DA/NIDA NIH HHS/United States
GR  - R01 DA016776/DA/NIDA NIH HHS/United States
GR  - R01 DA023567/DA/NIDA NIH HHS/United States
GR  - R01 DA027161/DA/NIDA NIH HHS/United States
PT  - Comment
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Clin Pharmacol Ther
JT  - Clinical pharmacology and therapeutics
JID - 0372741
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Nootropic Agents)
SB  - IM
CON - Clin Pharmacol Ther. 2010 Oct;88(4):459-61. PMID: 20856244
MH  - Central Nervous System Stimulants/administration & dosage/adverse
      effects/*therapeutic use
MH  - *Cognition
MH  - *Ethics, Clinical
MH  - Humans
MH  - Nootropic Agents/administration & dosage/adverse effects/*therapeutic use
EDAT- 2010/09/22 06:00
MHDA- 2010/10/21 06:00
CRDT- 2010/09/22 06:00
PHST- 2010/09/22 06:00 [entrez]
PHST- 2010/09/22 06:00 [pubmed]
PHST- 2010/10/21 06:00 [medline]
AID - clpt2010194 [pii]
AID - 10.1038/clpt.2010.194 [doi]
PST - ppublish
SO  - Clin Pharmacol Ther. 2010 Oct;88(4):461-3. doi: 10.1038/clpt.2010.194.


PMID- 20856089
OWN - NLM
STAT- MEDLINE
DCOM- 20110103
LR  - 20141009
IS  - 1542-538X (Electronic)
IS  - 0744-6020 (Linking)
VI  - 29
IP  - 5
DP  - 2010 Sep-Oct
TI  - Violation of a moral rule.
PG  - 338-41
LID - 10.1097/NOR.0b013e3181edd88d [doi]
AB  - A number of moral rules guide human actions. In addition, the acts of healthcare 
      providers are guided by professional codes of biomedical ethics. This article
      describes the rules and ethical principles at play when treatment is considered
      following hip fracture in an older adult with dementia.
FAU - Roberts, Dottie
AU  - Roberts D
AD  - South University, Columbia, SC, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Orthop Nurs
JT  - Orthopedic nursing
JID - 8409486
MH  - Aged
MH  - Aged, 80 and over
MH  - Dementia/complications
MH  - *Ethics, Medical
MH  - Female
MH  - Hip Fractures/complications/surgery
MH  - Humans
MH  - *Morals
EDAT- 2010/09/22 06:00
MHDA- 2011/01/05 06:00
CRDT- 2010/09/22 06:00
PHST- 2010/09/22 06:00 [entrez]
PHST- 2010/09/22 06:00 [pubmed]
PHST- 2011/01/05 06:00 [medline]
AID - 10.1097/NOR.0b013e3181edd88d [doi]
AID - 00006416-201009000-00010 [pii]
PST - ppublish
SO  - Orthop Nurs. 2010 Sep-Oct;29(5):338-41. doi: 10.1097/NOR.0b013e3181edd88d.


PMID- 20855144
OWN - NLM
STAT- MEDLINE
DCOM- 20110228
LR  - 20101018
IS  - 1768-319X (Electronic)
IS  - 0294-1260 (Linking)
VI  - 55
IP  - 5
DP  - 2010 Oct
TI  - [The surgical innovation: From the legal framework through the veritable ethics
      innovation - Technical aspects and practical applications].
PG  - 496-506
LID - 10.1016/j.anplas.2010.07.015 [doi]
AB  - Grace to the creativity of surgeons and the introduction of new technologies,
      second half of the XXth century opened the era of innovations and decisive
      progress. At the same time, however, is born the feeling of distrust and claiming
      which has come with the graving and threatening juridiciarisation. The evolution 
      of complex structures of our society joined the ingenuity researchers unlimited
      makes formal law and the legal framework constantly to adapt oneself to
      circumstances. In the field of surgery, it's necessary to make work in integrity 
      the innovation and protection at the patient's and their dignity. The legal
      framework that governs today innovation in surgery must still to go further and
      will precise. Dignity, compelling paradigm for all those who seek to better
      understand and better protect human starred as impassable limit any search and
      any experimentation. To make this chapter more alive, we have supplemented it and
      illustrated by the testimony some of the most fruitful French last years
      innovative in order to enrich our thinking of the fruit of their large and
      brilliant experience.
CI  - Copyright (c) 2010. Published by Elsevier SAS.
FAU - Flageul, G
AU  - Flageul G
AD  - gerard.flageul@wanadoo.fr
FAU - Aharoni, C
AU  - Aharoni C
FAU - Delay, E
AU  - Delay E
FAU - Desouches, C
AU  - Desouches C
FAU - Devauchelle, B
AU  - Devauchelle B
FAU - Guimberteau, J-C
AU  - Guimberteau JC
FAU - Lantieri, L
AU  - Lantieri L
FAU - Le Louarn, C
AU  - Le Louarn C
FAU - Magalon, G
AU  - Magalon G
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - L'innovation chirurgicale : du cadre legal a une veritable ethique de
      l'innovation. Aspects theoriques et applications pratiques.
DEP - 20100919
PL  - France
TA  - Ann Chir Plast Esthet
JT  - Annales de chirurgie plastique et esthetique
JID - 8305839
SB  - IM
MH  - France
MH  - Humans
MH  - Reconstructive Surgical Procedures/ethics/*legislation &
      jurisprudence/methods/trends
EDAT- 2010/09/22 06:00
MHDA- 2011/03/01 06:00
CRDT- 2010/09/22 06:00
PHST- 2010/06/30 00:00 [received]
PHST- 2010/07/01 00:00 [accepted]
PHST- 2010/09/22 06:00 [entrez]
PHST- 2010/09/22 06:00 [pubmed]
PHST- 2011/03/01 06:00 [medline]
AID - S0294-1260(10)00108-1 [pii]
AID - 10.1016/j.anplas.2010.07.015 [doi]
PST - ppublish
SO  - Ann Chir Plast Esthet. 2010 Oct;55(5):496-506. doi: 10.1016/j.anplas.2010.07.015.
      Epub 2010 Sep 19.


PMID- 20854751
OWN - NLM
STAT- MEDLINE
DCOM- 20101210
LR  - 20100921
IS  - 0040-5957 (Print)
IS  - 0040-5957 (Linking)
VI  - 65
IP  - 4
DP  - 2010 Jul-Aug
TI  - Clinical Trials Legislation - preparing for the revision of the European
      Directive Scheduled for 2011.
PG  - 301-8, 291-9
LID - 10.2515/therapie/2010038 [doi]
AB  - The aim of the Round Table was to make recommendations with regard to the
      imminent revision of the European Directive on clinical drug trials (2001/20/CE).
      While recognising the importance of compliance with this Directive, which is not 
      optimal in some member states of the European Union, it would be constructive to 
      simplify further and harmonise its application in every country. Without
      necessarily resorting to a revision, some of the Directive's dispositions could
      be improved, such as the definition of "investigational medicinal products" (IMP)
      and what should be considered as "substantial amendements", as well as
      harmonising and improving the way in which Ethics Committees are run, either on a
      European Commission level, or by relying more on the European Network of Research
      Ethics Committees (EUREC) which already exists in several European member states.
      Other points in the Directive do require revision, especially those relating to: 
      the definition of the respective roles of Ethics Committees and Competent
      Authorities, the simplification of safety information to Ethics Committees
      (giving them access to the Eudravigilance database for adverse reactions
      occurring during clinical trials and providing them with only new safety issues
      or with a summary of the Annual Safety Report), the possibility of one single
      European authorisation for the trial, centralised and/or decentralised, when the 
      trial is multinational. The recommended changes could be made within the scope of
      a European Regulation, avoiding the need to transpose it at a later date into
      each country's regulations, which is a source of possible lack of harmonisation. 
      More specifically, for trials with institutional sponsors and/or investigator
      driven trials such as "drug therapy strategy trials", modulating restrictions
      according to the "risk added by the research" would enable the trial's
      organisation to be simplified regarding monitoring, adverse reactions reporting
      and study drugs labelling.
CI  - (c) 2010 Societe Francaise de Pharmacologie et de Therapeutique.
FAU - Bilbault, Pascal
AU  - Bilbault P
AD  - Laboratoire Boehringer Ingelheim, Reims, France.
      pascal.bilbault@boehringer-ingelheim.com
FAU - Belorgey, Chantal
AU  - Belorgey C
FAU - Zannad, Faiez
AU  - Zannad F
FAU - Golinelli, Danielle
AU  - Golinelli D
FAU - Pletan, Yannick
AU  - Pletan Y
CN  - participants of Round Table n degrees 4 of Giens XXV
LA  - eng
LA  - fre
PT  - Journal Article
PT  - Review
DEP - 20100921
PL  - France
TA  - Therapie
JT  - Therapie
JID - 0420544
SB  - IM
MH  - Clinical Trials as Topic/ethics/*legislation & jurisprudence
MH  - Drug Industry
MH  - Ethics Committees, Research/legislation & jurisprudence
MH  - Europe
MH  - European Union
MH  - Guidelines as Topic
MH  - Humans
MH  - Legislation, Drug
MH  - Risk
IR  - Abiteboul M
FIR - Abiteboul, Michel
IR  - Bertram D
FIR - Bertram, Delphine
IR  - Cornu C
FIR - Cornu, Catherine
IR  - Chassany O
FIR - Chassany, Olivier
IR  - Demotes-Mainard J
FIR - Demotes-Mainard, Jacques
IR  - Demarez JP
FIR - Demarez, Jean-Paul
IR  - Diebolt V
FIR - Diebolt, Vincent
IR  - Dubray C
FIR - Dubray, Claude
IR  - Ericson M
FIR - Ericson, Mats
IR  - Orvoen EF
FIR - Orvoen, Elisabeth Frija
IR  - Hirsch F
FIR - Hirsch, Francois
IR  - Juillet Y
FIR - Juillet, Yves
IR  - Lamarque V
FIR - Lamarque, Veronique
IR  - Le Coent R
FIR - Le Coent, Remi
IR  - Libersa C
FIR - Libersa, Christian
IR  - Marey C
FIR - Marey, Christine
IR  - Marchenay B
FIR - Marchenay, Brigitta
IR  - Mijonnet A
FIR - Mijonnet, Armelle
IR  - Plattner V
FIR - Plattner, Valerie
IR  - Raison A
FIR - Raison, Anne
IR  - Rossignol P
FIR - Rossignol, Patrick
IR  - Rusch P
FIR - Rusch, Philippe
IR  - Sibenaler C
FIR - Sibenaler, Claire
IR  - Simon T
FIR - Simon, Tabassome
EDAT- 2010/09/22 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/09/22 06:00
PHST- 2010/03/29 00:00 [received]
PHST- 2010/04/23 00:00 [accepted]
PHST- 2010/09/22 06:00 [entrez]
PHST- 2010/09/22 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.2515/therapie/2010038 [doi]
AID - th101892 [pii]
PST - ppublish
SO  - Therapie. 2010 Jul-Aug;65(4):301-8, 291-9. doi: 10.2515/therapie/2010038. Epub
      2010 Sep 21.


PMID- 20854559
OWN - NLM
STAT- MEDLINE
DCOM- 20110119
LR  - 20220331
IS  - 1440-1630 (Electronic)
IS  - 0045-0766 (Linking)
VI  - 57
IP  - 1
DP  - 2010 Feb
TI  - Navigating ethical discharge planning: A case study in older adult
      rehabilitation.
PG  - 2-7
LID - 10.1111/j.1440-1630.2009.00826.x [doi]
AB  - BACKGROUND: Ethical issues are becoming more complex as individuals live longer
      with increased disability and medical needs. This article elucidates common
      ethical issues encountered in discharge planning with older adults. METHODS: We
      conducted normative ethical analysis of a clinical case using methods of
      philosophical inquiry, including thick description, reflexivity, conceptual
      clarification and examination of competing arguments for internal consistency.
      RESULTS: The analysis demonstrates how health-care teams struggle to balance
      protection from harm while honouring informed choices. We argue that ethical
      discharge planning requires judicious identification of client values, even if
      these conflict with team determinations of best interests. CONCLUSION: Dialogue
      is needed to identify risks, help clients determine their personal level of
      acceptable risk and determine provisions to minimise risks.
FAU - Durocher, Evelyne
AU  - Durocher E
AD  - Graduate Department of Rehabilitation Sciences, Collaborative Program in
      Bioethics, University of Toronto, Toronto, Ontario, Canada.
      evelyne.durocher@utoronto.ca
FAU - Gibson, Barbara E
AU  - Gibson BE
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Australia
TA  - Aust Occup Ther J
JT  - Australian occupational therapy journal
JID - 15420200R
SB  - IM
MH  - Aged, 80 and over
MH  - Beneficence
MH  - Canada
MH  - Decision Making
MH  - Ethical Analysis
MH  - Humans
MH  - Male
MH  - Mental Competency/*standards
MH  - Patient Discharge/*standards
MH  - *Patient Preference
MH  - Personal Autonomy
MH  - Quality of Life
MH  - Rehabilitation Centers/*ethics/organization & administration
MH  - Safety
MH  - Social Support
EDAT- 2010/09/22 06:00
MHDA- 2011/01/20 06:00
CRDT- 2010/09/22 06:00
PHST- 2010/09/22 06:00 [entrez]
PHST- 2010/09/22 06:00 [pubmed]
PHST- 2011/01/20 06:00 [medline]
AID - AOT826 [pii]
AID - 10.1111/j.1440-1630.2009.00826.x [doi]
PST - ppublish
SO  - Aust Occup Ther J. 2010 Feb;57(1):2-7. doi: 10.1111/j.1440-1630.2009.00826.x.


PMID- 20854151
OWN - NLM
STAT- MEDLINE
DCOM- 20110118
LR  - 20151119
IS  - 1466-187X (Electronic)
IS  - 0142-159X (Linking)
VI  - 32
IP  - 10
DP  - 2010
TI  - Competency-based integrated practical examinations: Bringing relevance to basic
      science laboratory examinations.
PG  - e443-7
LID - 10.3109/0142159X.2010.513405 [doi]
AB  - BACKGROUND: The practical examinations in subject-based curriculum have been
      criticized for lack of relevance and clinical application. We developed
      competency-based integrated practical examinations (IPEs) for first two years
      incorporating basic science principles with clinical relevance in our integrated 
      curriculum. AIM: To bring relevance to basic science laboratory practical
      examinations by conducting competency-based IPEs. METHODS: IPEs were developed
      according to competency-based blueprinting for each integrated module. Clinical
      scenarios were used as triggers followed by tasks pertaining to laboratory tests,
      relevant physical diagnosis and ethics/professional aspects utilizing
      standardized patients. Checklists were developed for standardized marking. A
      feedback questionnaire and two focus group discussions were administered to a
      random group of students from both first and second year students. Faculty
      members' feedback was also recorded on a questionnaire. RESULTS: Almost all the
      students agreed that IPE was a useful experience. Eighty-nine percent agreed that
      it was a fair examination and elicited a lesser degree of psychological stress.
      Eighty-two percent agreed that IPE encouraged critical thinking and application
      of knowledge. However, students suggested better organization and longer duration
      of stations. Faculty members also liked the experience. CONCLUSION: In
      conclusion, IPEs were well-received and valued both by students and faculty
      members.
FAU - Shafi, Riffat
AU  - Shafi R
AD  - Department of Basic Health Sciences, Shifa College of Medicine, Sector H-8/4,
      Islamabad, Pakistan. shafiriffat@hotmail.com
FAU - Irshad, Khurram
AU  - Irshad K
FAU - Iqbal, Mobeen
AU  - Iqbal M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Med Teach
JT  - Medical teacher
JID - 7909593
SB  - IM
MH  - Adult
MH  - Checklist
MH  - *Clinical Laboratory Techniques
MH  - Competency-Based Education/*organization & administration
MH  - Education, Medical/organization & administration
MH  - Educational Measurement/*methods
MH  - Focus Groups
MH  - Humans
MH  - Pakistan
MH  - Students, Medical
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2010/09/22 06:00
MHDA- 2011/01/19 06:00
CRDT- 2010/09/22 06:00
PHST- 2010/09/22 06:00 [entrez]
PHST- 2010/09/22 06:00 [pubmed]
PHST- 2011/01/19 06:00 [medline]
AID - 10.3109/0142159X.2010.513405 [doi]
PST - ppublish
SO  - Med Teach. 2010;32(10):e443-7. doi: 10.3109/0142159X.2010.513405.


PMID- 20853992
OWN - NLM
STAT- MEDLINE
DCOM- 20110211
LR  - 20151119
IS  - 1939-2222 (Electronic)
IS  - 0022-1015 (Linking)
VI  - 139
IP  - 4
DP  - 2010 Nov
TI  - When the future feels worse than the past: a temporal inconsistency in moral
      judgment.
PG  - 610-24
LID - 10.1037/a0020757 [doi]
AB  - Logically, an unethical behavior performed yesterday should also be unethical if 
      performed tomorrow. However, the present studies suggest that the timing of a
      transgression has a systematic effect on people's beliefs about its moral
      acceptability. Because people's emotional reactions tend to be more extreme for
      future events than for past events, and because such emotional reactions often
      guide moral intuitions, judgments of moral behavior may be more extreme in
      prospect than in retrospect. In 7 studies, participants judged future bad deeds
      more negatively, and future good deeds more positively, than equivalent behavior 
      in the equidistant past. In addition, participants thought that future unfair
      actions deserved more punishment than past unfair actions, and were more willing 
      to sacrifice their own financial gain to be treated fairly in the future compared
      with in the past. These patterns were explained in part by the stronger emotions 
      that were evoked by thoughts of future events than by thoughts of past events.
      Taken together, the results suggest that permission for actions with ethical
      connotations may be harder to get than forgiveness for those same actions, and
      demonstrate a systematic way in which moral judgments of the same action are
      inconsistent across time.
FAU - Caruso, Eugene M
AU  - Caruso EM
AD  - The University of Chicago, Booth School of Business, 5807 South Woodlawn Avenue, 
      Chicago, IL 60637, USA. ecaruso@chicagobooth.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Exp Psychol Gen
JT  - Journal of experimental psychology. General
JID - 7502587
SB  - IM
MH  - *Emotions
MH  - Humans
MH  - Imagination
MH  - Interpersonal Relations
MH  - *Judgment
MH  - *Morals
MH  - *Retrospective Moral Judgment
MH  - Surveys and Questionnaires
MH  - Time Factors
EDAT- 2010/09/22 06:00
MHDA- 2011/02/12 06:00
CRDT- 2010/09/22 06:00
PHST- 2010/09/22 06:00 [entrez]
PHST- 2010/09/22 06:00 [pubmed]
PHST- 2011/02/12 06:00 [medline]
AID - 2010-19226-001 [pii]
AID - 10.1037/a0020757 [doi]
PST - ppublish
SO  - J Exp Psychol Gen. 2010 Nov;139(4):610-24. doi: 10.1037/a0020757.


PMID- 20853615
OWN - NLM
STAT- MEDLINE
DCOM- 20101210
LR  - 20100921
IS  - 0040-3660 (Print)
IS  - 0040-3660 (Linking)
VI  - 82
IP  - 7
DP  - 2010
TI  - [Multiple myeloma in renal transplant recipients].
PG  - 76-9
AB  - Severe renal failure (RF) may be the first and only clinical manifestation of
      multiple myeloma (MM). Occasionally the disease remains long unrecognized and the
      patients receive renal function replacement therapy, including renal
      transplantation (RT). To treat MM in renal transplant recipients is a complex
      medical and ethical problem. The paper presents the authors' experience in
      treating 3 patients with MM diagnosed after RT and evolving transplant lesion.
      Various morphological types of grafted kidney lesion were detected. These
      included fibrillar glomerulonephritis, cast nephropathy, and the latter
      concurrent with light-chain deposition disease. RF most rapidly progressed in
      cast nephropathy. The natural history of the disease was unfavorable in all
      patients; VAD and PAD chemotherapy programs proved to be ineffective. It is
      concluded that RT should not be performed in patients with extended-stage MM due 
      to the fact that there is a considerable risk for renal transplant lesion and
      severe infectious complications that may occur during chemotherapy. Blood and
      urine immunochemical studies should be conducted in all the patients who are to
      undergo RT.
FAU - Rekhtina, I G
AU  - Rekhtina IG
FAU - Biriukova, L S
AU  - Biriukova LS
FAU - Varshavskii, V A
AU  - Varshavskii VA
FAU - Golitsina, G P
AU  - Golitsina GP
FAU - Savchenko, V G
AU  - Savchenko VG
LA  - rus
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
PL  - Russia (Federation)
TA  - Ter Arkh
JT  - Terapevticheskii arkhiv
JID - 2984818R
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
MH  - Diagnosis, Differential
MH  - Fatal Outcome
MH  - Graft Rejection/prevention & control
MH  - Humans
MH  - Immunosuppressive Agents/therapeutic use
MH  - Kidney Failure, Chronic/complications/diagnosis/*surgery
MH  - Kidney Transplantation/*adverse effects/*methods
MH  - Male
MH  - Middle Aged
MH  - Multiple Myeloma/complications/*diagnosis/drug therapy/surgery
MH  - Renal Dialysis
EDAT- 2010/09/22 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/09/22 06:00
PHST- 2010/09/22 06:00 [entrez]
PHST- 2010/09/22 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - Ter Arkh. 2010;82(7):76-9.


PMID- 20853396
OWN - NLM
STAT- MEDLINE
DCOM- 20110425
LR  - 20110128
IS  - 1098-2345 (Electronic)
IS  - 0275-2565 (Linking)
VI  - 73
IP  - 3
DP  - 2011 Mar
TI  - The first chimpanzee sanctuary in Japan: an attempt to care for the "surplus" of 
      biomedical research.
PG  - 226-32
LID - 10.1002/ajp.20887 [doi]
AB  - This article specifically examines several aspects of the human-captive
      chimpanzee bond and the effort to create the first chimpanzee sanctuary in Japan.
      We discuss our ethical responsibility for captive chimpanzees that have been used
      in biomedical research. On April 1, 2007, the Chimpanzee Sanctuary Uto (CSU) was 
      established as the first sanctuary for retired laboratory chimpanzees in Japan.
      This initiative was the result of the continuous efforts by members of Support
      for African/Asian Great Apes (SAGA), and the Great Ape Information Network to
      provide a solution to the large chimpanzee colony held in biomedical facilities. 
      However, the cessation of invasive biomedical studies using chimpanzees has
      created a new set of challenges because Japan lacks registration and laws banning
      invasive ape experiments and lacks a national policy for the life-long care of
      retired laboratory chimpanzees. Therefore, CSU has initiated a relocation program
      in which 79 retired laboratory chimpanzees will be sent to domestic zoos and
      receive life-long care. By the end of 2009, the number of chimpanzees living at
      CSU had decreased from 79 to 59 individuals. A nationwide network of care
      facilities and CSU to provide life-long care of retired laboratory chimpanzees is
      growing across Japan. This will result in humane treatment of these research
      animals.
CI  - 2010 Wiley-Liss, Inc.
FAU - Morimura, Naruki
AU  - Morimura N
AD  - Wildlife Research Center, Kyoto University, Kumamoto, Japan.
      nmorimura@wrc.kyoto-u.ac.jp
FAU - Idani, Gen'ichi
AU  - Idani G
FAU - Matsuzawa, Tetsuro
AU  - Matsuzawa T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100917
PL  - United States
TA  - Am J Primatol
JT  - American journal of primatology
JID - 8108949
SB  - IM
MH  - Animal Experimentation/*ethics/legislation & jurisprudence
MH  - Animal Welfare/*ethics/legislation & jurisprudence/*standards
MH  - Animals
MH  - Animals, Laboratory
MH  - Bioethical Issues
MH  - Biomedical Research/*ethics/legislation & jurisprudence
MH  - Endangered Species
MH  - Humans
MH  - Japan
MH  - Object Attachment
MH  - Pan troglodytes/*psychology
EDAT- 2010/09/21 06:00
MHDA- 2011/04/26 06:00
CRDT- 2010/09/21 06:00
PHST- 2009/09/04 00:00 [received]
PHST- 2010/08/09 00:00 [revised]
PHST- 2010/08/18 00:00 [accepted]
PHST- 2010/09/21 06:00 [entrez]
PHST- 2010/09/21 06:00 [pubmed]
PHST- 2011/04/26 06:00 [medline]
AID - 10.1002/ajp.20887 [doi]
PST - ppublish
SO  - Am J Primatol. 2011 Mar;73(3):226-32. doi: 10.1002/ajp.20887. Epub 2010 Sep 17.


PMID- 20853235
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20220309
IS  - 1469-5804 (Electronic)
IS  - 1357-6283 (Linking)
VI  - 23
IP  - 2
DP  - 2010 Aug
TI  - Brighter Smiles Africa--translation of a Canadian community-based
      health-promoting school program to Uganda.
PG  - 241
AB  - PROJECT GOAL: To adapt a successful Canadian health-promoting school initiative
      to a Ugandan context through international partnership. RATIONALE: Rural children
      face many health challenges worldwide; health professionals in training
      understand these better through community-based learning. Aboriginal leaders in a
      Canadian First-Nations community identified poor oral health as a child health
      issue with major long-term societal impact and intervened successfully with
      university partners through a school-based program called "Brighter Smiles".
      Makerere University, Kampala, Uganda (MUK) sought to implement this delivery
      model for both the benefit of communities and the dental students. KEY
      STEPS/HURDLES ADDRESSED: MUK identified rural communities where hospitals could
      provide dental students with community-based learning and recruited four local
      schools. A joint Ugandan and Canadian team of both trainees and faculty planned
      the program, obtained ethics consent and baseline data, initiated the Brighter
      Smiles intervention model (daily at-school tooth-brushing; in-class education),
      and recruited a cohort to receive additional bi-annual topical fluoride. Hurdles 
      included: challenging international communication and planning due to
      inconsistent internet connections; discrepancies between Canadian and developing 
      world concepts of research ethics and informed consent; complex dynamics for
      community engagement and steep learning curve for accurate data collection; an
      itinerant population at one school; and difficulties coordinating Canadian and
      Ugandan university schedules. ACCOMPLISHMENTS: Four health-promoting schools were
      established; teachers, children, and families were engaged in the initiative;
      community-based learning was adopted for the university students; quarterly team 
      education/evaluation/service delivery visits to schools were initiated; oral
      health improved, and new knowledge and practices were evident; an effective
      international partnership was formed providing global health education, research 
      and health care delivery.
FAU - Macnab, A J
AU  - Macnab A
AD  - University of British Columbia, Vancouver, British Columbia.
FAU - Radziminski, N
AU  - Radziminski N
FAU - Budden, H
AU  - Budden H
FAU - Kasangaki, A
AU  - Kasangaki A
FAU - Zavuga, R
AU  - Zavuga R
FAU - Gagnon, F A
AU  - Gagnon F
FAU - Mbabali, M
AU  - Mbabali M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100717
PL  - India
TA  - Educ Health (Abingdon)
JT  - Education for health (Abingdon, England)
JID - 9607101
SB  - IM
MH  - Canada
MH  - Child
MH  - Child Welfare
MH  - Delivery of Health Care/organization & administration
MH  - Dental Health Services/*organization & administration
MH  - Dentistry
MH  - Health Education/*organization & administration
MH  - *Health Promotion
MH  - Health Services Accessibility
MH  - Health Services Needs and Demand
MH  - Humans
MH  - International Cooperation
MH  - Learning
MH  - Oral Health
MH  - Poverty
MH  - *Program Development
MH  - Rural Health Services/organization & administration
MH  - School Health Services/*organization & administration
MH  - Socioeconomic Factors
MH  - Uganda
EDAT- 2010/09/21 06:00
MHDA- 2011/01/07 06:00
CRDT- 2010/09/21 06:00
PHST- 2010/09/21 06:00 [entrez]
PHST- 2010/09/21 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
AID - 241 [pii]
PST - ppublish
SO  - Educ Health (Abingdon). 2010 Aug;23(2):241. Epub 2010 Jul 17.


PMID- 20853170
OWN - NLM
STAT- MEDLINE
DCOM- 20120424
LR  - 20211020
IS  - 1433-7339 (Electronic)
IS  - 0941-4355 (Linking)
VI  - 19
IP  - 11
DP  - 2011 Nov
TI  - "When patients and families feel abandoned".
PG  - 1713-7
LID - 10.1007/s00520-010-1007-6 [doi]
AB  - PURPOSE: Patients with serious illness derive a sense of security by forming
      strong, healing relationships with their providers. These bonds are particularly 
      strong in life-threatening illnesses, such as cancer, which carry the stigma of
      death and suffering. These strong relationships create expectations in patients
      that are not necessarily shared by their clinicians. Providers often focus on
      treating disease and emphasize technically excellent, "evidence-based" practice
      while failing to fully appreciate the power of the patient-provider relationship.
      In contrast, vulnerable patients expect much more than technical competence,
      including open and clear communication, security, continuity, and access.
      Patients are often left feeling abandoned when their providers do not meet their 
      expectations, even when their care is technically sound. METHODS/RESULTS: In this
      paper, we describe scenarios that can lead to feelings of abandonment and discuss
      strategies to avoid and respond to them. CONCLUSIONS: These strategies can help
      us maintain healing relationships with our patients by maintaining their trust,
      confidence, and satisfaction. Cultivating relational aspects of medical practice 
      requires an interchange and takes time. Experienced doctors know this and
      continue to do so because being present and staying with the patient during
      difficult times is a pillar of moral and ethical training and a fundamental
      attribute of a good physician.
FAU - Epner, Daniel E
AU  - Epner DE
AD  - Department of General Oncology, MD Anderson Cancer Center, Houston, TX 77030,
      USA. depner@mdanderson.org
FAU - Ravi, Vinod
AU  - Ravi V
FAU - Baile, Walter F
AU  - Baile WF
LA  - eng
PT  - Journal Article
DEP - 20100919
PL  - Germany
TA  - Support Care Cancer
JT  - Supportive care in cancer : official journal of the Multinational Association of 
      Supportive Care in Cancer
JID - 9302957
SB  - IM
MH  - Communication
MH  - Continuity of Patient Care
MH  - Family/*psychology
MH  - Health Services Accessibility
MH  - Humans
MH  - Neoplasms/*psychology
MH  - Patient Satisfaction
MH  - *Physician-Patient Relations
MH  - Refusal to Treat
MH  - Trust
EDAT- 2010/09/21 06:00
MHDA- 2012/04/25 06:00
CRDT- 2010/09/21 06:00
PHST- 2010/07/09 00:00 [received]
PHST- 2010/09/07 00:00 [accepted]
PHST- 2010/09/21 06:00 [entrez]
PHST- 2010/09/21 06:00 [pubmed]
PHST- 2012/04/25 06:00 [medline]
AID - 10.1007/s00520-010-1007-6 [doi]
PST - ppublish
SO  - Support Care Cancer. 2011 Nov;19(11):1713-7. doi: 10.1007/s00520-010-1007-6. Epub
      2010 Sep 19.


PMID- 20853091
OWN - NLM
STAT- MEDLINE
DCOM- 20110218
LR  - 20160707
IS  - 1437-1588 (Electronic)
IS  - 1436-9990 (Linking)
VI  - 53
IP  - 9
DP  - 2010 Sep
TI  - [Terminal care in the form of sedation at the end of life. Current medical ethics
      recommendations and further need for discussion].
PG  - 939-42
LID - 10.1007/s00103-010-1120-1 [doi]
FAU - Kress, H
AU  - Kress H
AD  - Evang.-Theol. Fakultat, Abt. Sozialethik, Universitat Bonn, Am Hof 1, 53113 Bonn.
      hkress@uni-bonn.de
LA  - ger
PT  - Journal Article
TT  - Sterbehilfe in Form der Sedierung am Lebensende. Aktuelle medizinethische
      Empfehlungen und weiterer Diskussionsbedarf.
PL  - Germany
TA  - Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
JT  - Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
JID - 101181368
SB  - IM
MH  - Advance Directive Adherence/ethics/legislation & jurisprudence
MH  - Advance Directives/*ethics/*legislation & jurisprudence
MH  - Deep Sedation/*ethics
MH  - *Ethics, Medical
MH  - Euthanasia, Active, Voluntary/*ethics/*legislation & jurisprudence
MH  - Germany
MH  - Humans
MH  - Legal Guardians/legislation & jurisprudence
MH  - *Personal Autonomy
MH  - Physician's Role
MH  - Religion and Medicine
MH  - Resuscitation Orders/ethics
MH  - Suicide, Assisted/ethics/legislation & jurisprudence
MH  - Terminal Care/*ethics/*legislation & jurisprudence
EDAT- 2010/09/21 06:00
MHDA- 2011/02/22 06:00
CRDT- 2010/09/21 06:00
PHST- 2010/09/21 06:00 [entrez]
PHST- 2010/09/21 06:00 [pubmed]
PHST- 2011/02/22 06:00 [medline]
AID - 10.1007/s00103-010-1120-1 [doi]
PST - ppublish
SO  - Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2010
      Sep;53(9):939-42. doi: 10.1007/s00103-010-1120-1.


PMID- 20853083
OWN - NLM
STAT- MEDLINE
DCOM- 20110218
LR  - 20160707
IS  - 1437-1588 (Electronic)
IS  - 1436-9990 (Linking)
VI  - 53
IP  - 9
DP  - 2010 Sep
TI  - [Priorization in healthcare. An important duty, an unnecessary luxury, or playing
      with fire? A sociomedical point of view].
PG  - 874-81
LID - 10.1007/s00103-010-1112-1 [doi]
AB  - While setting priorities in healthcare has been discussed internationally for
      about 25 years, attempts to even start a discussion in Germany have failed for
      more than a decade. On the contrary, the topic was and still is actively
      suppressed. In this respect, one helpful mechanism is to deliberately or
      carelessly confuse prioritization with rationing, a German taboo-word. The
      national healthcare debate again and again neglects the question on what to spend
      Germany's still very considerable resources. This helps our health politicians to
      continue to live the postulate that everybody should have immediate, unrestricted
      access to all medically indicated healthcare. Attempts to distinguish between
      priority setting and rationing as two entirely distinct programs based on
      prioritization models from Sweden, England, and Oregon/USA are presented. While
      discussing possible objects, levels, criteria, ethics, and normative implications
      of priority setting in healthcare, recent recommendations of a permanent
      vaccination committee (STIKO) are used as an example.
FAU - Raspe, H
AU  - Raspe H
AD  - Institut fur Sozialmedizin, Universitat und Universitatsklinikum
      Schleswig-Holstein, Campus Lubeck, Ratzeburger Allee 160, 23538 Lubeck.
      heiner.raspe@uk-sh.de
LA  - ger
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
TT  - Priorisierung in der medizinischen Versorgung. Unabweisbare Aufgabe, unnutzer
      Luxus oder Spiel mit dem Feuer? Eine sozialmedizinische Position.
PL  - Germany
TA  - Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
JT  - Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
JID - 101181368
SB  - IM
MH  - Bioethics/trends
MH  - Cost Control/economics/trends
MH  - Cross-Cultural Comparison
MH  - Delivery of Health Care/economics/trends
MH  - Forecasting
MH  - Germany
MH  - Health Care Rationing/economics/*trends
MH  - Health Priorities/economics/*trends
MH  - Health Services Accessibility/economics/trends
MH  - Humans
MH  - National Health Programs/economics/*trends
EDAT- 2010/09/21 06:00
MHDA- 2011/02/22 06:00
CRDT- 2010/09/21 06:00
PHST- 2010/09/21 06:00 [entrez]
PHST- 2010/09/21 06:00 [pubmed]
PHST- 2011/02/22 06:00 [medline]
AID - 10.1007/s00103-010-1112-1 [doi]
PST - ppublish
SO  - Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2010
      Sep;53(9):874-81. doi: 10.1007/s00103-010-1112-1.


PMID- 20853082
OWN - NLM
STAT- MEDLINE
DCOM- 20110218
LR  - 20160707
IS  - 1437-1588 (Electronic)
IS  - 1436-9990 (Linking)
VI  - 53
IP  - 9
DP  - 2010 Sep
TI  - [Ethical basis of priority setting in healthcare].
PG  - 867-73
LID - 10.1007/s00103-010-1116-x [doi]
AB  - The debate about priorities in healthcare has also started in Germany. Because of
      the special moral significance of health and healthcare, priority setting in
      healthcare also involves ethical issues. After clarifying the relationship
      between priority setting and rationing, I first discuss whether it is ethically
      acceptable or even mandated to set priorities in healthcare. If this first
      question is answered with "yes", the following question is how the priorities can
      be determined in an ethically defensible way. I will try to show that it is
      impossible to justify priorities in healthcare within a liberal theory of justice
      that is neutral towards substantive conceptions of the good life. We rather need 
      a deliberative decision process about how we want to live in the face of illness,
      suffering, and death. Only by reference to a substantial concept of a good life
      is it possible to define and justify healthcare priorities. A national
      priority-setting commission could play an important role in stimulating this
      deliberation and developing general recommendations according to which criteria
      and procedures priorities should be set in the German healthcare system. The
      application of this general framework requires the cooperation of medical
      scientific and physician organizations.
FAU - Marckmann, G
AU  - Marckmann G
AD  - Institut fur Ethik und Geschichte der Medizin, Universitat Tubingen, Tubingen.
      georg.marckmann@uni-tuebingen.de
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Ethische Grundlagen der Priorisierung im Gesundheitswesen.
PL  - Germany
TA  - Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
JT  - Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
JID - 101181368
SB  - IM
MH  - *Bioethics
MH  - Cost Savings/ethics
MH  - Delivery of Health Care/economics/ethics
MH  - Germany
MH  - Health Care Rationing/economics/*ethics
MH  - Health Priorities/economics/*ethics
MH  - Health Services Accessibility/economics/ethics
MH  - Humans
MH  - National Health Programs/economics/*ethics
EDAT- 2010/09/21 06:00
MHDA- 2011/02/22 06:00
CRDT- 2010/09/21 06:00
PHST- 2010/09/21 06:00 [entrez]
PHST- 2010/09/21 06:00 [pubmed]
PHST- 2011/02/22 06:00 [medline]
AID - 10.1007/s00103-010-1116-x [doi]
PST - ppublish
SO  - Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2010
      Sep;53(9):867-73. doi: 10.1007/s00103-010-1116-x.


PMID- 20852801
OWN - NLM
STAT- MEDLINE
DCOM- 20110422
LR  - 20211020
IS  - 1757-9708 (Electronic)
IS  - 1757-9694 (Linking)
VI  - 2
IP  - 10
DP  - 2010 Oct
TI  - Integrative genome-wide approaches in embryonic stem cell research.
PG  - 510-6
LID - 10.1039/c0ib00068j [doi]
AB  - Embryonic stem (ES) cells are derived from blastocysts. They can differentiate
      into the three embryonic germ layers and essentially any type of somatic cells.
      They therefore hold great potential in tissue regeneration therapy. The ethical
      issues associated with the use of human embryonic stem cells are resolved by the 
      technical break-through of generating induced pluripotent stem (iPS) cells from
      various types of somatic cells. However, how ES and iPS cells self-renew and
      maintain their pluripotency is still largely unknown in spite of the great
      progress that has been made in the last two decades. Integrative genome-wide
      approaches, such as the gene expression microarray, chromatin immunoprecipitation
      based microarray (ChIP-chip) and chromatin immunoprecipitation followed by
      massive parallel sequencing (ChIP-seq) offer unprecedented opportunities to
      elucidate the mechanism of the pluripotency, reprogramming and DNA damage
      response of ES and iPS cells. This frontier article summarizes the fundamental
      biological questions about ES and iPS cells and reviews the recent advances in ES
      and iPS cell research using genome-wide technologies. To this end, we offer our
      perspectives on the future of genome-wide studies on stem cells.
FAU - Zhang, Xinyue
AU  - Zhang X
AD  - Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda,
      MD 20892, USA.
FAU - Huang, Jing
AU  - Huang J
LA  - eng
GR  - ZIA BC011260-01/ImNIH/Intramural NIH HHS/United States
GR  - Z99 CA999999/ImNIH/Intramural NIH HHS/United States
GR  - ZIA BC011158-02/ImNIH/Intramural NIH HHS/United States
GR  - ZIA BC011158-01/ImNIH/Intramural NIH HHS/United States
GR  - ZIA BC011158-03/ImNIH/Intramural NIH HHS/United States
GR  - ZIA BC011260-02/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
DEP - 20100920
PL  - England
TA  - Integr Biol (Camb)
JT  - Integrative biology : quantitative biosciences from nano to macro
JID - 101478378
RN  - 0 (Histones)
RN  - 0 (RNA, Messenger)
RN  - 0 (Retroelements)
RN  - 0 (Transcription Factors)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Animals
MH  - Cell Dedifferentiation/physiology
MH  - Chromatin Immunoprecipitation/methods
MH  - DNA/metabolism
MH  - DNA Damage/physiology
MH  - DNA Methylation/physiology
MH  - Embryonic Stem Cells/*cytology/*metabolism
MH  - Endogenous Retroviruses/genetics
MH  - Epigenesis, Genetic/physiology
MH  - Genome/*genetics
MH  - Genomics
MH  - Histones/metabolism
MH  - Humans
MH  - Oligonucleotide Array Sequence Analysis/methods
MH  - Pluripotent Stem Cells/cytology/physiology
MH  - Protein Binding/genetics
MH  - RNA, Messenger/genetics
MH  - Retroelements/genetics
MH  - Sequence Analysis, DNA/methods
MH  - Sequence Analysis, RNA/methods
MH  - *Stem Cell Research
MH  - Transcription Factors/metabolism
PMC - PMC3400334
MID - NIHMS387110
EDAT- 2010/09/21 06:00
MHDA- 2011/04/26 06:00
CRDT- 2010/09/21 06:00
PHST- 2010/09/21 06:00 [entrez]
PHST- 2010/09/21 06:00 [pubmed]
PHST- 2011/04/26 06:00 [medline]
AID - 10.1039/c0ib00068j [doi]
PST - ppublish
SO  - Integr Biol (Camb). 2010 Oct;2(10):510-6. doi: 10.1039/c0ib00068j. Epub 2010 Sep 
      20.


PMID- 20852529
OWN - NLM
STAT- MEDLINE
DCOM- 20101207
LR  - 20161125
IS  - 1462-4753 (Print)
IS  - 1462-4753 (Linking)
VI  - 15
IP  - 9
DP  - 2010 Sep
TI  - Consent and capacity: a guide for district nurses.
PG  - 456-60
AB  - The Mental Capacity Act 2005, which came into force in 2007, sought to provide a 
      statutory framework to facilitate empowerment and provide protection to
      individuals who lack capacity. District nurses must be aware of the legislation
      regarding mental capacity (Nursing and Midwifery Council, 2008) and understand
      how and when they may need to assess decision-making capacity. The article
      explores the legal and ethical issues surrounding consent, and seeks to inform
      district nurses as to the guidelines used in assessing a person's capacity to
      consent, along with best interests policy.
FAU - Ford, Lorna
AU  - Ford L
AD  - Manchester Metropolitan University. lorna.ford4@ntlworld.com
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Br J Community Nurs
JT  - British journal of community nursing
JID - 9815827
MH  - Adult
MH  - Aged
MH  - Dementia/nursing
MH  - Female
MH  - Humans
MH  - Informed Consent/ethics/*legislation & jurisprudence
MH  - Leg Ulcer/nursing
MH  - Mental Competency/*legislation & jurisprudence
MH  - Nursing Assessment/ethics/organization & administration
MH  - Patient Advocacy/ethics/*legislation & jurisprudence
MH  - Practice Guidelines as Topic
MH  - Principle-Based Ethics
MH  - Public Health Nursing/ethics/*legislation & jurisprudence
MH  - Treatment Refusal/ethics/legislation & jurisprudence
MH  - United Kingdom
EDAT- 2010/09/21 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/09/21 06:00
PHST- 2010/09/21 06:00 [entrez]
PHST- 2010/09/21 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.12968/bjcn.2010.15.9.78105 [doi]
PST - ppublish
SO  - Br J Community Nurs. 2010 Sep;15(9):456-60. doi: 10.12968/bjcn.2010.15.9.78105.


PMID- 20852500
OWN - NLM
STAT- MEDLINE
DCOM- 20101216
LR  - 20100920
IS  - 1750-8460 (Print)
IS  - 1750-8460 (Linking)
VI  - 71
IP  - 8
DP  - 2010 Aug
TI  - An ethical dilemma on call.
PG  - M126-7
FAU - Ahmad, Z
AU  - Ahmad Z
AD  - Salisbury District Hospital, Salisbury, Wiltshire.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Hosp Med (Lond)
JT  - British journal of hospital medicine (London, England : 2005)
JID - 101257109
SB  - IM
MH  - Abdominal Pain/etiology
MH  - Ethics, Medical
MH  - Female
MH  - Humans
MH  - Physical Examination/*ethics
MH  - Substance Abuse Detection/*ethics
EDAT- 2010/09/21 06:00
MHDA- 2010/12/17 06:00
CRDT- 2010/09/21 06:00
PHST- 2010/09/21 06:00 [entrez]
PHST- 2010/09/21 06:00 [pubmed]
PHST- 2010/12/17 06:00 [medline]
AID - 10.12968/hmed.2010.71.Sup8.77683 [doi]
PST - ppublish
SO  - Br J Hosp Med (Lond). 2010 Aug;71(8):M126-7. doi:
      10.12968/hmed.2010.71.Sup8.77683.


PMID- 20852402
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20211020
IS  - 1938-808X (Electronic)
IS  - 1040-2446 (Linking)
VI  - 85
IP  - 11
DP  - 2010 Nov
TI  - Tightening conflict-of-interest policies: the impact of 2005 ethics rules at the 
      NIH.
PG  - 1685-91
LID - 10.1097/ACM.0b013e3181f578b2 [doi]
AB  - PURPOSE: To determine both the intended and unintended effects of the National
      Institutes of Health (NIH) 2005 ethics rules by examining changes in publishing
      rates and the frequency of external relationships among NIH scientists. METHOD:
      After identifying eligible intramural scientists and administrators from
      institutes' Web pages and central directories, a mailed survey was administered
      to 900 NIH research faculty between October 2008 and January 2009 (response rate 
      70.1%). RESULTS: Eighty percent of respondents believed the NIH ethics rules were
      too restrictive. Whereas 45% of respondents believed the rules positively
      impacted the public's trust in the NIH, 77% believed the rules hindered the NIH's
      ability to complete its mission. Implementation of the ethics rules significantly
      decreased self-reported government-industry relationships among NIH faculty (from
      51.8% to 33.2%, P < .01), including significant drops in consulting (33.1% to
      7.8%, P < .01) and scientific advisory board membership (31.5% to 16.0%, P <
      .01), both of which may be allowed under the new regulations in restricted
      situations with increased oversight. The policy had limited impact on NIH faculty
      participation in nonindustrial professional service roles and had no detectable
      change in publishing behavior (5.29 articles per researcher per year from
      2002-2005 versus 5.26 from 2005-2008, P = .88). CONCLUSIONS: The NIH ethics rules
      accomplished much of what they were intended to do, limiting relationships with
      industry while maintaining NIH researchers' association with external scientific 
      and professional organizations. However, the rules negatively affected personnel 
      morale and the perceived progress of research.
FAU - Zinner, Darren E
AU  - Zinner DE
AD  - Schneider Institutes for Health Policy, Heller School of Social Policy and
      Management, Brandeis University, Waltham, Massachusetts 02454, USA.
      dzinner@brandeis.edu
FAU - DesRoches, Catherine M
AU  - DesRoches CM
FAU - Bristol, Steffanie J
AU  - Bristol SJ
FAU - Clarridge, Brian
AU  - Clarridge B
FAU - Campbell, Eric G
AU  - Campbell EG
LA  - eng
GR  - R01 GM084455/GM/NIGMS NIH HHS/United States
GR  - 5R01GM0844455-01/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Acad Med
JT  - Academic medicine : journal of the Association of American Medical Colleges
JID - 8904605
SB  - IM
CIN - Acad Med. 2010 Nov;85(11):1660-2. PMID: 20980848
MH  - Biomedical Research/*ethics
MH  - Chi-Square Distribution
MH  - *Conflict of Interest
MH  - *Ethics, Research
MH  - Humans
MH  - Logistic Models
MH  - *National Institutes of Health (U.S.)
MH  - Publishing/statistics & numerical data
MH  - Research Support as Topic/*ethics
MH  - Surveys and Questionnaires
MH  - Technology Transfer
MH  - United States
PMC - PMC3767378
MID - NIHMS503098
EDAT- 2010/09/21 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/09/21 06:00
PHST- 2010/09/21 06:00 [entrez]
PHST- 2010/09/21 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1097/ACM.0b013e3181f578b2 [doi]
PST - ppublish
SO  - Acad Med. 2010 Nov;85(11):1685-91. doi: 10.1097/ACM.0b013e3181f578b2.


PMID- 20852303
OWN - NLM
STAT- MEDLINE
DCOM- 20110315
LR  - 20101129
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 12
DP  - 2010 Dec
TI  - Access to investigational medicinal products for minors in Europe: ethical and
      regulatory issues in negotiating children's access to investigational medicines.
PG  - 791-4
LID - 10.1136/jme.2010.036442 [doi]
AB  - Patients who search for a better treatment, an increased quality of life, or even
      a chance to preserve life itself may claim to have an interest in accessing
      investigational medicinal products (IMP), particularly when no validated
      treatment for their disease or condition exists. For many, awaiting the uncertain
      and time-consuming process of converting an IMP into an approved drug may not
      appear a realistic option, as prognoses may be grim and a dramatic outcome may
      seem hard to avert. Gaining access to an IMP, however, often proves to be a
      difficult enterprise with a highly uncertain outcome. In addition, the process of
      seeking access to IMP is surrounded by various ethical issues that will be
      explored in this article. This paper explores the ethical concerns in two
      potential tracks of seeking access to IMP for minors: on an individual basis, or 
      collectively, as a patient organisation. In this discourse, several unique
      ethical and regulatory concerns related to the direct negotiation of access to
      IMP for minor patients are identified, with a focus on product safety, the
      recruitment of research subjects, the unnoticed entry of market mechanisms in the
      recruitment of research subjects, and the sidelining of third parties in the
      recruitment process. The paper concludes with a concise reflection on the way
      forward. The quest for access to investigational drugs is particularly relevant
      to paediatric practice, in which a significant share of the drugs prescribed has 
      never been tested in children or labelled for use in the paediatric population.
FAU - Pinxten, Wim
AU  - Pinxten W
AD  - Katholieke Universiteit Leuven, Centre for Biomedical Ethics and Law, Leuven,
      Belgium. wim.pinxten@med.kuleuven.be
FAU - Nys, Herman
AU  - Nys H
FAU - Dierickx, Kris
AU  - Dierickx K
LA  - eng
PT  - Journal Article
DEP - 20100918
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
RN  - 0 (Drugs, Investigational)
SB  - IM
MH  - Adolescent
MH  - Biomedical Research/ethics
MH  - Child
MH  - Drugs, Investigational/*therapeutic use
MH  - *Ethics, Medical
MH  - Europe
MH  - Female
MH  - Health Services Accessibility
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Male
MH  - *Minors
MH  - Patient Rights/ethics
MH  - Patient Selection/ethics
EDAT- 2010/09/21 06:00
MHDA- 2011/03/16 06:00
CRDT- 2010/09/21 06:00
PHST- 2010/09/21 06:00 [entrez]
PHST- 2010/09/21 06:00 [pubmed]
PHST- 2011/03/16 06:00 [medline]
AID - jme.2010.036442 [pii]
AID - 10.1136/jme.2010.036442 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Dec;36(12):791-4. doi: 10.1136/jme.2010.036442. Epub 2010 Sep 
      18.


PMID- 20852302
OWN - NLM
STAT- MEDLINE
DCOM- 20110315
LR  - 20161125
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 12
DP  - 2010 Dec
TI  - Neurotrauma and the RUB: where tragedy meets ethics and science.
PG  - 727-30
LID - 10.1136/jme.2010.037424 [doi]
AB  - Decompressive craniectomy is a technically straightforward procedure whereby a
      large section of the cranium is temporarily removed in cases where the
      intracranial pressure is dangerously high. While its use has been described for a
      number of conditions, it is increasingly used in the context of severe head
      injury. As the use of the procedure increases, a significant number of patients
      may survive a severe head injury who otherwise would have died. Unfortunately
      some of these patients will be left severely disabled; a condition likened to the
      RUB, an acronym for the Risk of Unacceptable Badness. Until recently it has been 
      difficult to predict this outcome, however an accurate prediction model has been 
      developed and this has been applied to a large cohort of patients in Western
      Australia. It is possible to compare the predicted outcome with the observed
      outcome at 18&emsp14;months within this cohort. By using predicted and observed
      outcome data this paper considers the ethical implications in three cases of
      differing severity of head injury in view of the fact that it is possible to
      calculate the RUB for each case.
FAU - Gillett, G R
AU  - Gillett GR
AD  - Otago Bioethics Centre, University of Otago Medical School, 201 Great King St,
      Dunedin (PO Box 913), New Zealand. grant.gillett@stonebow.otago.ac.nz
FAU - Honeybul, S
AU  - Honeybul S
FAU - Ho, K M
AU  - Ho KM
FAU - Lind, C R P
AU  - Lind CR
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20100918
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Australia
MH  - Brain Injuries/diagnostic imaging/*surgery
MH  - Cohort Studies
MH  - Craniotomy/ethics/*statistics & numerical data
MH  - Decompression, Surgical/ethics/*statistics & numerical data
MH  - Disability Evaluation
MH  - Ethics, Medical
MH  - Female
MH  - Humans
MH  - Injury Severity Score
MH  - Male
MH  - Middle Aged
MH  - Models, Biological
MH  - Predictive Value of Tests
MH  - Tomography, X-Ray Computed
MH  - Treatment Outcome
EDAT- 2010/09/21 06:00
MHDA- 2011/03/16 06:00
CRDT- 2010/09/21 06:00
PHST- 2010/09/21 06:00 [entrez]
PHST- 2010/09/21 06:00 [pubmed]
PHST- 2011/03/16 06:00 [medline]
AID - jme.2010.037424 [pii]
AID - 10.1136/jme.2010.037424 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Dec;36(12):727-30. doi: 10.1136/jme.2010.037424. Epub 2010 Sep
      18.


PMID- 20852225
OWN - NLM
STAT- MEDLINE
DCOM- 20110301
LR  - 20181201
IS  - 1943-3662 (Electronic)
IS  - 1093-6793 (Linking)
VI  - 38
IP  - 3
DP  - 2010
TI  - Normative versus consequential ethics in sexually violent predator laws: an
      ethics conundrum for psychiatry.
PG  - 386-91
AB  - Nineteen states and the federal government have statutes for the civil commitment
      of sexually violent predators (SVP). The American Psychiatric Association has
      vigorously opposed SVP laws, citing the abuse of both individual civil rights and
      of psychiatry in forwarding preventive detention. Those who support the laws
      underscore that the statutes target highly dangerous sex offenders. There are two
      different approaches to understanding ethics-based problems and their solutions. 
      The normative approach assumes that there is a universal, intuitive, abstract,
      correct answer to a given question. However, there is no universal right way to
      balance the important normative ethic of protecting individual rights with the
      equally important normative ethic of protecting public safety. A less universal
      approach, consequential ethics, becomes necessary when abstract normative values 
      conflict and lead to opposing conclusions. In this commentary, we examine and
      attempt to resolve the conflicting positions raised by the SVP statutes by using 
      consequential versus normative ethics.
FAU - Sreenivasan, Shoba
AU  - Sreenivasan S
AD  - Keck School of Medicine, University of Southern California, Los Angeles, CA
      90086-0125, USA.
FAU - Frances, Allen
AU  - Frances A
FAU - Weinberger, Linda E
AU  - Weinberger LE
LA  - eng
PT  - Journal Article
PT  - Legal Case
PL  - United States
TA  - J Am Acad Psychiatry Law
JT  - The journal of the American Academy of Psychiatry and the Law
JID - 9708963
SB  - IM
MH  - Humans
MH  - Psychiatry/*ethics
MH  - Sex Offenses/*legislation & jurisprudence
MH  - Stalking/*psychology
MH  - Supreme Court Decisions
MH  - United States
EDAT- 2010/09/21 06:00
MHDA- 2011/03/02 06:00
CRDT- 2010/09/21 06:00
PHST- 2010/09/21 06:00 [entrez]
PHST- 2010/09/21 06:00 [pubmed]
PHST- 2011/03/02 06:00 [medline]
AID - 38/3/386 [pii]
PST - ppublish
SO  - J Am Acad Psychiatry Law. 2010;38(3):386-91.


PMID- 20852133
OWN - NLM
STAT- MEDLINE
DCOM- 20101112
LR  - 20220409
IS  - 1530-8561 (Electronic)
IS  - 0009-9147 (Linking)
VI  - 56
IP  - 11
DP  - 2010 Nov
TI  - Human tissue ownership and use in research: what laboratorians and researchers
      should know.
PG  - 1675-82
LID - 10.1373/clinchem.2010.150672 [doi]
AB  - BACKGROUND: The use of human blood and tissue is critical to biomedical research.
      A number of treaties, laws, and regulations help to guide the ethical collection 
      of these specimens. However, there are no clearly defined regulations regarding
      the ownership of human tissue specimens and who can control their fate. CONTENT: 
      This review discusses the existing regulations governing human studies and the
      necessary components of patient consent. Legal cases that have addressed the
      issue of ownership of human tissue are reviewed, including recent settlements
      that have led to the destruction of millions of specimens of patient tissue. The 
      unique regulations that guide the use of tissues collected postmortem are also
      examined. Potential changes in the future of biomedical research that uses human 
      tissue, including genetic material, are also discussed. SUMMARY: The use of human
      tissue is directed by numerous laws and regulations. Awareness of these rules and
      of how and when to obtain meaningful informed consent from patients is essential 
      for laboratorians and researchers, who should also be familiar with situations
      that have led to lawsuits and in some cases the destruction of valuable human
      tissue specimens.
FAU - Allen, Monica J
AU  - Allen MJ
AD  - Office of the Executive Vice Chancellor and General Counsel, Washington
      University School of Medicine St. Louis, MO 63110, USA.
FAU - Powers, Michelle L E
AU  - Powers ML
FAU - Gronowski, K Scott
AU  - Gronowski KS
FAU - Gronowski, Ann M
AU  - Gronowski AM
LA  - eng
PT  - Journal Article
PT  - Legal Case
PT  - Review
DEP - 20100917
PL  - England
TA  - Clin Chem
JT  - Clinical chemistry
JID - 9421549
SB  - IM
MH  - Biological Specimen Banks/*legislation & jurisprudence
MH  - Biomedical Research/*legislation & jurisprudence
MH  - Humans
MH  - Informed Consent/legislation & jurisprudence
MH  - Ownership/*legislation & jurisprudence
MH  - Specimen Handling
MH  - United States
EDAT- 2010/09/21 06:00
MHDA- 2010/11/13 06:00
CRDT- 2010/09/21 06:00
PHST- 2010/09/21 06:00 [entrez]
PHST- 2010/09/21 06:00 [pubmed]
PHST- 2010/11/13 06:00 [medline]
AID - clinchem.2010.150672 [pii]
AID - 10.1373/clinchem.2010.150672 [doi]
PST - ppublish
SO  - Clin Chem. 2010 Nov;56(11):1675-82. doi: 10.1373/clinchem.2010.150672. Epub 2010 
      Sep 17.


PMID- 20851698
OWN - NLM
STAT- MEDLINE
DCOM- 20111219
LR  - 20110829
IS  - 1878-0326 (Electronic)
IS  - 1872-4973 (Linking)
VI  - 5
IP  - 5
DP  - 2011 Nov
TI  - Launching the Greek forensic DNA database. The legal framework and arising
      ethical issues.
PG  - 407-10
LID - 10.1016/j.fsigen.2010.08.013 [doi]
AB  - Since the creation of the first national DNA database in Europe in 1995, many
      European countries have legislated laws for initiating and regulating their own
      databases. The Greek government legislated a law in 2008, by which the National
      DNA Database of Greece was founded and regulated. According to this law, only DNA
      profiles from convicted criminals were recorded. Nevertheless, a year later, in
      2009, the law was amended to permit the creation of an expanded database
      including innocent people and children. Unfortunately, the new law is very vague 
      in many aspects and does not respect the principle of proportionality. Therefore,
      according to our opinion, it will soon need to be re-amended. Furthermore, prior 
      to legislating the new law, there was no debate with the community itself in
      order to clarify what system would best suit Greece and what the citizens would
      be willing to accept. We present the current legal framework in Greece, we
      highlight issues that need to be clarified and we discuss possible ethical issues
      that may arise.
CI  - Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Voultsos, Polychronis
AU  - Voultsos P
AD  - Laboratory of Forensic Medicine and Toxicology, School of Medicine, Aristotle
      University of Thessaloniki, Greece.
FAU - Njau, Samuel
AU  - Njau S
FAU - Tairis, Nikolaos
AU  - Tairis N
FAU - Psaroulis, Dimitrios
AU  - Psaroulis D
FAU - Kovatsi, Leda
AU  - Kovatsi L
LA  - eng
PT  - Journal Article
DEP - 20100918
PL  - Netherlands
TA  - Forensic Sci Int Genet
JT  - Forensic science international. Genetics
JID - 101317016
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - DNA/*genetics
MH  - *Databases, Genetic
MH  - *Ethics
MH  - *Forensic Genetics
MH  - Greece
MH  - Humans
EDAT- 2010/09/21 06:00
MHDA- 2011/12/20 06:00
CRDT- 2010/09/21 06:00
PHST- 2010/06/30 00:00 [received]
PHST- 2010/08/12 00:00 [revised]
PHST- 2010/08/23 00:00 [accepted]
PHST- 2010/09/21 06:00 [entrez]
PHST- 2010/09/21 06:00 [pubmed]
PHST- 2011/12/20 06:00 [medline]
AID - S1872-4973(10)00131-6 [pii]
AID - 10.1016/j.fsigen.2010.08.013 [doi]
PST - ppublish
SO  - Forensic Sci Int Genet. 2011 Nov;5(5):407-10. doi: 10.1016/j.fsigen.2010.08.013. 
      Epub 2010 Sep 18.


PMID- 20850602
OWN - NLM
STAT- MEDLINE
DCOM- 20110218
LR  - 20100920
IS  - 0013-7006 (Print)
IS  - 0013-7006 (Linking)
VI  - 36
IP  - 4
DP  - 2010 Sep
TI  - [Neurological soft signs in pervasive developmental disorders].
PG  - 307-13
LID - 10.1016/j.encep.2009.12.012 [doi]
AB  - BACKGROUND: Many studies have focused on specific motor signs in autism and
      Asperger's syndrome, but few has been published on the complete range of
      neurological soft signs (NSS) in children with pervasive developmental disorder
      (PDD). Scarce are the studies evaluating NSS in children suffering from PDD not
      otherwise specified (PDDNOS). METHODS: This study compared performance of 11
      autistic children (AD) and 10 children with PDDNOS, with controls matched on age,
      sex and cognitive performance on Krebs et al.'s NSS scale. Because of the
      duration of the assessments and specific difficulties encountered in managing
      some items, an adaptation of the scale had to be made during a pilot study with
      the agreement of the author. To be eligible, patients had to meet the following
      inclusion criteria: an age range of 6-16 years, a diagnosis of autistic disorder 
      or PDDNOS based on the DSM IV criteria (American Psychiatric Association 1994).
      The autism diagnostic interview-revised (ADI-R) was used in order to confirm the 
      diagnosis and to evaluate the association of the symptoms to the severity of the 
      NSS. The childhood autism rating scale (CARS) was completed for the patients in
      order to evaluate symptoms at the time of the NSS examination. Cognitive ability 
      was assessed with Raven's progressive matrices. Were excluded patients with:
      history of cerebral palsy, congenital anomaly of the central nervous system,
      epilepsy, known genetic syndrome, tuberous sclerosis, neurofibromatosis,
      antecedent of severe head trauma, Asperger's syndrome, obvious physical
      deformities or sensory deficits that would interfere with neurological
      assessment, deep mental retardation and recent or chronic substance use or abuse.
      Healthy controls shared the same exclusion criteria, with no personal history of 
      neurological, psychiatric disorder or substance abuse, no family history of
      psychiatric disorder and normal or retardation in schooling. All study procedures
      were approved by the local Ethics Committee (Comite d'ethique, Razi Hospital),
      according to the declaration of Helsinki. RESULTS: There was no difference
      between patients and controls with respect to sex, age and cognitive function.
      All children had an IQ higher than 81. Significant differences were found between
      AD children and control group in the motor integration function and sensory
      integration function. Different NSS scores were significantly higher in the
      PDDNOS group than in controls: the total scores, motor coordination, motor
      integration function, sensory integration and abnormal movements. Lower
      performance in motor coordination skills was associated with higher ADI-R
      communication score in the AD group. No relationship was found between NSS and
      CARS' total sore. CONCLUSION: This study confirms the impaired neurological
      functioning in autistic as well as PDDNOS children. The association of motor
      impairment with autistic symptoms highlights the argument that motor control
      problems can be part of the autism spectrum disorders. The lack of relationship
      between NSS and intellectual aptitude in the clinical sample provides new
      elements for the neurodevelopment model of the autism spectrum.
CI  - Copyright (c) 2010 L'Encephale, Paris. Published by Elsevier Masson SAS. All
      rights reserved.
FAU - Halayem, S
AU  - Halayem S
AD  - Service de Pedopsychiatrie, Hopital Razi, rue des Orangers, 2010 La-Manouba,
      Tunisie. soumeyyadhouib@yahoo.fr
FAU - Bouden, A
AU  - Bouden A
FAU - Halayem, M B
AU  - Halayem MB
FAU - Tabbane, K
AU  - Tabbane K
FAU - Amado, I
AU  - Amado I
FAU - Krebs, M O
AU  - Krebs MO
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Signes neurologiques mineurs et troubles envahissants du developpement.
DEP - 20100307
PL  - France
TA  - Encephale
JT  - L'Encephale
JID - 7505643
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child Development Disorders, Pervasive/*diagnosis/psychology
MH  - Comorbidity
MH  - Female
MH  - Humans
MH  - Intelligence
MH  - Male
MH  - Motor Skills Disorders/*diagnosis/psychology
MH  - Nervous System Diseases/*diagnosis/psychology
MH  - Neurologic Examination/*methods
EDAT- 2010/09/21 06:00
MHDA- 2011/02/22 06:00
CRDT- 2010/09/21 06:00
PHST- 2009/03/13 00:00 [received]
PHST- 2009/10/19 00:00 [accepted]
PHST- 2010/09/21 06:00 [entrez]
PHST- 2010/09/21 06:00 [pubmed]
PHST- 2011/02/22 06:00 [medline]
AID - S0013-7006(09)00261-9 [pii]
AID - 10.1016/j.encep.2009.12.012 [doi]
PST - ppublish
SO  - Encephale. 2010 Sep;36(4):307-13. doi: 10.1016/j.encep.2009.12.012. Epub 2010 Mar
      7.


PMID- 20850572
OWN - NLM
STAT- MEDLINE
DCOM- 20110310
LR  - 20101129
IS  - 1876-4347 (Electronic)
IS  - 1871-6784 (Linking)
VI  - 27
IP  - 5
DP  - 2010 Nov 30
TI  - Ethical arguments relevant to the use of GM crops.
PG  - 582-7
LID - 10.1016/j.nbt.2010.08.013 [doi]
AB  - The Nuffield Council on Bioethics (NCOB) has published two reports (1999 and
      2004) on the social and ethical issues involved in the use of genetically
      modified crops. This presentation summarises their core ethical arguments. Five
      sets of ethical concerns have been raised about GM crops: potential harm to human
      health; potential damage to the environment; negative impact on traditional
      farming practice; excessive corporate dominance; and the 'unnaturalness' of the
      technology. The NCOB examined these claims in the light of the principle of
      general human welfare, the maintenance of human rights and the principle of
      justice. It concluded in relation to the issue of 'unnaturalness' that GM
      modification did not differ to such an extent from conventional breeding that it 
      is in itself morally objectionable. In making an assessment of possible costs,
      benefits and risks, it was necessary to proceed on a case-by-case basis. However,
      the potential to bring about significant benefits in developing countries
      (improved nutrition, enhanced pest resistance, increased yields and new products)
      meant that there was an ethical obligation to explore these potential benefits
      responsibly, to contribute to the reduction of poverty, and improve food security
      and profitable agriculture in developing countries. NCOB held that these
      conclusions were consistent with any practical precautionary approach. In
      particular, in applying a precautionary approach the risks associated with the
      status quo need to be considered, as well as any risks inherent in the
      technology. These ethical requirements have implications for the governance of
      the technology, in particular mechanisms for enabling small-scale farmers to
      express their preferences for traits selected by plant breeders and mechanisms
      for the diffusion of risk-based evaluations.
CI  - Copyright (c) 2010 Elsevier B.V. All rights reserved.
FAU - Weale, Albert
AU  - Weale A
AD  - Nuffield Council on Bioethics, 28 Bedford Square, London WC1B 3JS, UK.
      a.weale@ucl.ac.uk
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100917
PL  - Netherlands
TA  - N Biotechnol
JT  - New biotechnology
JID - 101465345
SB  - IM
MH  - Agriculture/ethics/methods
MH  - *Bioethical Issues
MH  - Bioethics
MH  - Crops, Agricultural/*genetics
MH  - Food Supply/ethics
MH  - Humans
MH  - Plants, Genetically Modified/*genetics
MH  - Risk Assessment
EDAT- 2010/09/21 06:00
MHDA- 2011/03/11 06:00
CRDT- 2010/09/21 06:00
PHST- 2010/08/27 00:00 [received]
PHST- 2010/08/30 00:00 [accepted]
PHST- 2010/09/21 06:00 [entrez]
PHST- 2010/09/21 06:00 [pubmed]
PHST- 2011/03/11 06:00 [medline]
AID - S1871-6784(10)00564-9 [pii]
AID - 10.1016/j.nbt.2010.08.013 [doi]
PST - ppublish
SO  - N Biotechnol. 2010 Nov 30;27(5):582-7. doi: 10.1016/j.nbt.2010.08.013. Epub 2010 
      Sep 17.


PMID- 20849598
OWN - NLM
STAT- MEDLINE
DCOM- 20110811
LR  - 20220409
IS  - 1471-2318 (Electronic)
IS  - 1471-2318 (Linking)
VI  - 10
DP  - 2010 Sep 17
TI  - Engaging the oldest old in research: lessons from the Newcastle 85+ study.
PG  - 64
LID - 10.1186/1471-2318-10-64 [doi]
AB  - BACKGROUND: Those aged 85 and over, the oldest old, are now the fastest growing
      sector of the population. Information on their health is essential to inform
      future planning; however, there is a paucity of up-to-date information on the
      oldest old, who are often excluded from research. The aim of the Newcastle 85+
      Study is to investigate the health of a cohort of 85-year-olds from a biological,
      medical and psychosocial perspective. This paper describes the methods employed
      for the successful recruitment, retention and evaluation of this cohort. METHODS:
      Participants were all individuals born in 1921 and registered with a
      participating general practice in Newcastle and North Tyneside, UK. Involvement
      comprised detailed health assessments, by a nurse, in their usual place of
      residence and/or review of their general practice medical records. RESULTS: Of
      the 1453 individuals eligible to participate, 72% (n = 1042) were recruited; 59% 
      (n = 851) consented to both health assessment and review of general practice
      records. Key factors for successful involvement included protected time to engage
      with family and other key gatekeepers, minimising participant burden, through for
      example home based assessment, and flexibility of approach. Cognitive impairment 
      is a significant issue; due consideration should be given to the ethical and
      legal issues of capacity and consent. Interim withdrawal rates at phase 2 (18
      month post baseline), show 88 out of 854 participants (10%) had withdrawn with
      approval for continued use of data and materials and a further 2 participants
      (0.2%) had withdrawn and requested that all data be destroyed. Attrition due to
      death of participants within this same time frame was 135 (16%). CONCLUSION: Our 
      recruitment rates were good and compared favourably with other similar UK and
      international longitudinal studies of the oldest old. The challenges of and
      successful strategies for involving, recruiting and retaining the oldest old in
      research, including those in institutions, are described to facilitate adequate
      representation of this growing population in future research into ageing.
FAU - Davies, Karen
AU  - Davies K
AD  - Institute for Ageing and Health, Newcastle University, Campus for Ageing and
      Vitality, Newcastle upon Tyne, NE4 5PL, UK. Karen.davies@ncl.ac.uk
FAU - Collerton, Joanna C
AU  - Collerton JC
FAU - Jagger, Carol
AU  - Jagger C
FAU - Bond, John
AU  - Bond J
FAU - Barker, Sally A H
AU  - Barker SA
FAU - Edwards, June
AU  - Edwards J
FAU - Hughes, Joan
AU  - Hughes J
FAU - Hunt, Judith M
AU  - Hunt JM
FAU - Robinson, Louise
AU  - Robinson L
LA  - eng
GR  - G0500997/MRC_/Medical Research Council/United Kingdom
GR  - G0500997/BB_/Biotechnology and Biological Sciences Research Council/United
      Kingdom
GR  - BHF_/British Heart Foundation/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100917
PL  - England
TA  - BMC Geriatr
JT  - BMC geriatrics
JID - 100968548
SB  - IM
MH  - Age Factors
MH  - Aged, 80 and over/*psychology
MH  - Biomedical Research/*methods
MH  - Cohort Studies
MH  - Family/psychology
MH  - Homes for the Aged
MH  - Humans
MH  - Mental Competency/psychology
MH  - Patient Participation/*methods/*psychology
MH  - *Patient Selection
MH  - United Kingdom
PMC - PMC2945353
EDAT- 2010/09/21 06:00
MHDA- 2011/08/13 06:00
CRDT- 2010/09/21 06:00
PHST- 2010/04/08 00:00 [received]
PHST- 2010/09/17 00:00 [accepted]
PHST- 2010/09/21 06:00 [entrez]
PHST- 2010/09/21 06:00 [pubmed]
PHST- 2011/08/13 06:00 [medline]
AID - 1471-2318-10-64 [pii]
AID - 10.1186/1471-2318-10-64 [doi]
PST - epublish
SO  - BMC Geriatr. 2010 Sep 17;10:64. doi: 10.1186/1471-2318-10-64.


PMID- 20849589
OWN - NLM
STAT- MEDLINE
DCOM- 20101228
LR  - 20211203
IS  - 1532-429X (Electronic)
IS  - 1097-6647 (Linking)
VI  - 12
DP  - 2010 Sep 17
TI  - An isolated perfused pig heart model for the development, validation and
      translation of novel cardiovascular magnetic resonance techniques.
PG  - 53
LID - 10.1186/1532-429X-12-53 [doi]
AB  - BACKGROUND: Novel cardiovascular magnetic resonance (CMR) techniques and imaging 
      biomarkers are often validated in small animal models or empirically in patients.
      Direct translation of small animal CMR protocols to humans is rarely possible,
      while validation in humans is often difficult, slow and occasionally not possible
      due to ethical considerations. The aim of this study is to overcome these
      limitations by introducing an MR-compatible, free beating, blood-perfused,
      isolated pig heart model for the development of novel CMR methodology. METHODS: 6
      hearts were perfused outside of the MR environment to establish preparation
      stability. Coronary perfusion pressure (CPP), coronary blood flow (CBF), left
      ventricular pressure (LVP), arterial blood gas and electrolyte composition were
      monitored over 4 hours. Further hearts were perfused within 3T (n = 3) and 1.5T
      (n = 3) clinical MR scanners, and characterised using functional (CINE),
      perfusion and late gadolinium enhancement (LGE) imaging. Perfusion imaging was
      performed globally and selectively for the right (RCA) and left coronary artery
      (LCA). In one heart the RCA perfusion territory was determined and compared to
      infarct size after coronary occlusion. RESULTS: All physiological parameters
      measured remained stable and within normal ranges. The model proved amenable to
      CMR at both field strengths using typical clinical acquisitions. There was good
      agreement between the RCA perfusion territory measured by selective first pass
      perfusion and LGE after coronary occlusion (37% versus 36% of the LV
      respectively). CONCLUSIONS: This flexible model allows imaging of cardiac
      function in a controllable, beating, human-sized heart using clinical MR systems.
      It should aid further development, validation and clinical translation of novel
      CMR methodologies, and imaging sequences.
FAU - Schuster, Andreas
AU  - Schuster A
AD  - King's College London BHF Centre of Excellence, NIHR Biomedical Research Centre, 
      Guy's and St, Thomas' NHS Foundation Trust, Division of Imaging Sciences, The
      Rayne Institute, London, UK.
FAU - Grunwald, Inga
AU  - Grunwald I
FAU - Chiribiri, Amedeo
AU  - Chiribiri A
FAU - Southworth, Richard
AU  - Southworth R
FAU - Ishida, Masaki
AU  - Ishida M
FAU - Hay, Gunnar
AU  - Hay G
FAU - Neumann, Nicole
AU  - Neumann N
FAU - Morton, Geraint
AU  - Morton G
FAU - Perera, Divaka
AU  - Perera D
FAU - Schaeffter, Tobias
AU  - Schaeffter T
FAU - Nagel, Eike
AU  - Nagel E
LA  - eng
GR  - FS/10/029/28253/BHF_/British Heart Foundation/United Kingdom
GR  - RE/08/003/BHF_/British Heart Foundation/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20100917
PL  - England
TA  - J Cardiovasc Magn Reson
JT  - Journal of cardiovascular magnetic resonance : official journal of the Society
      for Cardiovascular Magnetic Resonance
JID - 9815616
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 1BJ477IO2L (gadobutrol)
SB  - IM
MH  - Animals
MH  - Contrast Media
MH  - *Coronary Circulation
MH  - Coronary Occlusion/complications/*diagnosis/physiopathology
MH  - Disease Models, Animal
MH  - Feasibility Studies
MH  - *Magnetic Resonance Imaging, Cine
MH  - Myocardial Infarction/*diagnosis/etiology/physiopathology
MH  - Myocardial Perfusion Imaging/*methods
MH  - Myocardium/*pathology
MH  - Organometallic Compounds
MH  - Perfusion
MH  - Predictive Value of Tests
MH  - Reproducibility of Results
MH  - Swine
MH  - *Translational Research, Biomedical
MH  - Ventricular Function
MH  - Ventricular Pressure
PMC - PMC2950014
EDAT- 2010/09/21 06:00
MHDA- 2010/12/29 06:00
CRDT- 2010/09/21 06:00
PHST- 2010/06/21 00:00 [received]
PHST- 2010/09/17 00:00 [accepted]
PHST- 2010/09/21 06:00 [entrez]
PHST- 2010/09/21 06:00 [pubmed]
PHST- 2010/12/29 06:00 [medline]
AID - 1532-429X-12-53 [pii]
AID - 10.1186/1532-429X-12-53 [doi]
PST - epublish
SO  - J Cardiovasc Magn Reson. 2010 Sep 17;12:53. doi: 10.1186/1532-429X-12-53.


PMID- 20849298
OWN - NLM
STAT- MEDLINE
DCOM- 20110329
LR  - 20101019
IS  - 1557-7708 (Electronic)
IS  - 1075-5535 (Linking)
VI  - 16
IP  - 10
DP  - 2010 Oct
TI  - Provider support for CAM: usefulness, ethics, and dilemma.
PG  - 1029
LID - 10.1089/acm.2010.0417 [doi]
FAU - Wiwanitkit, Viroj
AU  - Wiwanitkit V
LA  - eng
PT  - Comment
PT  - Letter
DEP - 20100919
PL  - United States
TA  - J Altern Complement Med
JT  - Journal of alternative and complementary medicine (New York, N.Y.)
JID - 9508124
SB  - IM
CON - J Altern Complement Med. 2010 Jul;16(7):745-52. PMID: 20575703
MH  - Complementary Therapies/ethics/*standards
MH  - Developing Countries
MH  - Health Personnel/*ethics
MH  - Humans
EDAT- 2010/09/21 06:00
MHDA- 2011/03/30 06:00
CRDT- 2010/09/21 06:00
PHST- 2010/09/21 06:00 [entrez]
PHST- 2010/09/21 06:00 [pubmed]
PHST- 2011/03/30 06:00 [medline]
AID - 10.1089/acm.2010.0417 [doi]
PST - ppublish
SO  - J Altern Complement Med. 2010 Oct;16(10):1029. doi: 10.1089/acm.2010.0417. Epub
      2010 Sep 19.


PMID- 20849297
OWN - NLM
STAT- MEDLINE
DCOM- 20110125
LR  - 20211020
IS  - 1931-843X (Electronic)
IS  - 1540-9996 (Linking)
VI  - 19
IP  - 11
DP  - 2010 Nov
TI  - Navigating the challenges of global reproductive health research.
PG  - 2101-7
LID - 10.1089/jwh.2010.2065 [doi]
AB  - Reproductive health research in low-resource settings poses unique and complex
      challenges that must be addressed to ensure that global research is conducted
      with strict adherence to ethical principles, offers direct benefit to the
      research subjects, and has the potential for adoption of positive findings to the
      target population. This article addresses challenges to conducting reproductive
      health research in low-resource settings in the following areas: (1)
      establishment and maintenance of global collaboration, (2) community
      partnerships, (3) ethical issues, including informed consent and the role of
      incentives, (4) staff training and development, (5) data collection and
      management, and (6) infrastructure and logistics. Particular attention to these
      challenges is important to ensure that research is culturally appropriate and
      methodologically sound and enhances the adoption of health-promoting behaviors.
      Rigorous evaluation of interventions in low-resource settings may be a
      cost-effective and time-efficient way to identify interventions for large-scale
      program replication to improve women's health.
FAU - Stenson, Amy L
AU  - Stenson AL
AD  - David Geffen School of Medicine at the University of California, Los Angeles,
      California 90095, USA. astenson@mednet.ucla.edu
FAU - Kapungu, Chisina T
AU  - Kapungu CT
FAU - Geller, Stacie E
AU  - Geller SE
FAU - Miller, Suellen
AU  - Miller S
LA  - eng
GR  - K01 MH089729-01/MH/NIMH NIH HHS/United States
PT  - Journal Article
DEP - 20100919
PL  - United States
TA  - J Womens Health (Larchmt)
JT  - Journal of women's health (2002)
JID - 101159262
SB  - IM
MH  - Community Participation
MH  - Developing Countries
MH  - *Global Health
MH  - Health Services Research/ethics/*organization & administration/standards
MH  - Humans
MH  - Informed Consent
MH  - *International Cooperation
MH  - *Reproductive Medicine
MH  - Staff Development
PMC - PMC3004132
EDAT- 2010/09/21 06:00
MHDA- 2011/01/28 06:00
CRDT- 2010/09/21 06:00
PHST- 2010/09/21 06:00 [entrez]
PHST- 2010/09/21 06:00 [pubmed]
PHST- 2011/01/28 06:00 [medline]
AID - 10.1089/jwh.2010.2065 [doi]
PST - ppublish
SO  - J Womens Health (Larchmt). 2010 Nov;19(11):2101-7. doi: 10.1089/jwh.2010.2065.
      Epub 2010 Sep 19.


PMID- 20849217
OWN - NLM
STAT- MEDLINE
DCOM- 20110201
LR  - 20171116
IS  - 1933-0693 (Electronic)
IS  - 0022-3085 (Linking)
VI  - 114
IP  - 1
DP  - 2011 Jan
TI  - Pitfalls in the publication of scientific literature: a road map to manage
      conflict of interest and other ethical challenges.
PG  - 21-6
LID - 10.3171/2010.8.JNS091834 [doi]
AB  - The process of publishing scientific research can be hampered by potential
      pitfalls for journals and researchers alike; the definition and determination of 
      authorship, legal documentation, data accuracy, and disclosure of financial
      conflicts of interest are all examples. In the current article, the authors
      discuss the challenges related to scientific medical writing and provide updated 
      recommendations for both the prevention and management of these issues.
FAU - Patel, Alpesh A
AU  - Patel AA
AD  - Department of Orthopaedic Surgery, University of Utah, Salt Lake City, Utah
      84108, USA. alpesh.patel@hsc.utah.edu
FAU - Whang, Peter G
AU  - Whang PG
FAU - White, Andrew P
AU  - White AP
FAU - Fehlings, Michael G
AU  - Fehlings MG
FAU - Vaccaro, Alexander R
AU  - Vaccaro AR
LA  - eng
PT  - Journal Article
DEP - 20100917
PL  - United States
TA  - J Neurosurg
JT  - Journal of neurosurgery
JID - 0253357
SB  - IM
CIN - J Neurosurg. 2011 Jan;114(1):19-20; discussion 20. PMID: 20849219
MH  - Bias
MH  - Biomedical Research/economics/*ethics
MH  - *Conflict of Interest
MH  - Humans
MH  - Neurosurgery/economics/*ethics
MH  - Peer Review
MH  - Periodicals as Topic/economics/*ethics
EDAT- 2010/09/21 06:00
MHDA- 2011/02/02 06:00
CRDT- 2010/09/21 06:00
PHST- 2010/09/21 06:00 [entrez]
PHST- 2010/09/21 06:00 [pubmed]
PHST- 2011/02/02 06:00 [medline]
AID - 10.3171/2010.8.JNS091834 [doi]
PST - ppublish
SO  - J Neurosurg. 2011 Jan;114(1):21-6. doi: 10.3171/2010.8.JNS091834. Epub 2010 Sep
      17.


PMID- 20849002
OWN - NLM
STAT- MEDLINE
DCOM- 20101102
LR  - 20211020
IS  - 1470-2118 (Print)
IS  - 1470-2118 (Linking)
VI  - 10
IP  - 4
DP  - 2010 Aug
TI  - Assisted suicide and voluntary euthanasia: role contradictions for physicians.
PG  - 323-5
AB  - It is widely assumed by the general public that if assisted suicide (AS) or
      euthanasia (VE) were legalised doctors must be essentially involved in the whole 
      process including prescribing the medication and (in euthanasia) administering
      it. This paper explores some reasons for this assumption and argues that it
      flatly contradicts what it means to be a doctor. The paper is thus not mainly
      concerned with the ethics of AS/VE but rather with the concept of a doctor that
      has evolved since the time of Hippocrates to current professional guidance
      reflected in healthcare law. The paper argues that the most common recent
      argument for AS/VE--that patients have a right to control when and how they
      die--in fact points to the involvement not of doctors but of legal agencies as
      decision makers plus technicians as agents.
FAU - Randall, Fiona
AU  - Randall F
AD  - Royal Bournemouth Christchurch Hospitals NHS Foundation Trust.
      fiona.randall@rbch.nhs.uk
FAU - Downie, Robin
AU  - Downie R
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Med (Lond)
JT  - Clinical medicine (London, England)
JID - 101092853
SB  - IM
CIN - Clin Med (Lond). 2010 Aug;10(4):319-20. PMID: 20849000
CIN - Clin Med (Lond). 2011 Feb;11(1):97; author reply 97-8. PMID: 21404799
MH  - Choice Behavior
MH  - *Euthanasia, Active, Voluntary
MH  - Humans
MH  - Palliative Care
MH  - Personal Autonomy
MH  - *Physician's Role
MH  - *Suicide, Assisted
MH  - Terminally Ill
MH  - United Kingdom
PMC - PMC4952157
EDAT- 2010/09/21 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/09/21 06:00
PHST- 2010/09/21 06:00 [entrez]
PHST- 2010/09/21 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - 10.7861/clinmedicine.10-4-323 [doi]
PST - ppublish
SO  - Clin Med (Lond). 2010 Aug;10(4):323-5. doi: 10.7861/clinmedicine.10-4-323.


PMID- 20848804
OWN - NLM
STAT- MEDLINE
DCOM- 20101101
LR  - 20151119
IS  - 0391-9714 (Print)
IS  - 0391-9714 (Linking)
VI  - 32
IP  - 1
DP  - 2010
TI  - The embryo in ancient Rabbinic literature: between religious law and didactic
      narratives. An interpretive essay.
PG  - 21-41
AB  - At a time when bioethical issues are at the top of public and political agendas, 
      there is a renewed interest in representations of the embryo in various religious
      traditions. One of the major traditions that has contributed to Western
      representations of the embryo is the Jewish tradition. This tradition poses some 
      difficulties that may deter scholars, but also presents some invaluable
      advantages. These derive from two components, the search for limits and
      narrativity, both of which are directly connected with the manner in which Jewish
      tradition was constructed in Antiquity. The article accomplishes three goals: To 
      introduce some central elements in ancient Rabbinic literature on the subject of 
      the embryo and its representation; To present this body of literature as clearly 
      as possible, noting some of the difficulties encountered by scholars who engage
      in its study; To explain how the literature's textuality came about, examining
      the particular sociopolitical circumstances of Judaism at that time, including
      the reasons for the delay in the production of scientific texts, transmitted as
      such, as compared to other philosophical or religious traditions. The article
      claims that these circumstances engendered a tradition peculiarly relevant for
      the study and teaching of medical ethics today.
FAU - Lepicard, Etienne
AU  - Lepicard E
AD  - La Maison du Pressoir, Bet hagat, Ein Karem D 72, 95744 Jerusalem, Israel.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - Switzerland
TA  - Hist Philos Life Sci
JT  - History and philosophy of the life sciences
JID - 8003052
SB  - IM
MH  - *Abortion, Induced
MH  - *Abortion, Spontaneous
MH  - *Embryonic Development
MH  - Female
MH  - *Fetus/physiology
MH  - History, Ancient
MH  - History, Medieval
MH  - Humans
MH  - Infant, Newborn
MH  - *Judaism/history
MH  - Male
MH  - Marriage
MH  - Parturition
MH  - Pregnancy
MH  - *Religion and Medicine
MH  - Stillbirth
EDAT- 2010/09/21 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/09/21 06:00
PHST- 2010/09/21 06:00 [entrez]
PHST- 2010/09/21 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
PST - ppublish
SO  - Hist Philos Life Sci. 2010;32(1):21-41.


PMID- 20847370
OWN - NLM
STAT- MEDLINE
DCOM- 20110124
LR  - 20191210
IS  - 0971-5916 (Print)
IS  - 0971-5916 (Linking)
VI  - 132
DP  - 2010 Sep
TI  - Utility of Prevention of Parent-to-Child Transmission (PPTCT). Programme data for
      HIV surveillance in general population.
PG  - 256-9
AB  - BACKGROUND & OBJECTIVES: HIV sentinel surveillance (HSS) among antenatal clinic
      (ANC) attendees is used to monitor HIV trends in general population. Recently,
      information on HIV infection has also become available from prevention of
      parent-to-child transmission (PPTCT) programmes. Systematic appraisal of
      routinely collected programme data is needed for choosing a scientific,
      cost-effective, and ethical surveillance strategy. In this study HIV prevalence
      estimates obtained from PPTCT programme and HSS were compared to find out the
      utility of PPTCT programme data for HIV surveillance. METHODS: The data of HSS
      and PPTCT programme were obtained from National AIDS Control Organization, New
      Delhi. A list of PPTCT programme sites where ANC HSS was also conducted during
      2005 to 2007 was prepared. HIV prevalence and 95 per cent confidence interval
      (CI) were estimated from antenatal attendees in PPTCT and HSS. Correlation
      coefficient of HIV prevalence in PPTCT and HSS was also examined according to the
      level of HIV test acceptance in PPTCT programme. Pregnant women presenting
      directly for labour in PPTCT centers were not included in the analyses. RESULTS: 
      In 2007, HIV test acceptance ranged from 8 to 100 per cent (average 76%) in 372
      sites where both PPTCT and HSS were carried out. HIV prevalence was similar in
      the PPTCT (0.68%, 95% CI 0.66%, 0.70%) as compared to the HSS (0.61%, 95% CI
      0.58%, 0.66%). Overall the correlation of HIV prevalence between PPTCT and HSS
      was quite high at state level (r = 0.9) but low at district or site level (r =
      0.6). INTERPRETATION & CONCLUSIONS: HIV prevalence estimates among pregnant women
      in PPTCT program were similar to that of ANC HSS. Routinely collected PPTCT
      program data therefore has potential for providing reliable HIV time trends in
      various states of India.
FAU - Kumar, Rajesh
AU  - Kumar R
AD  - Postgraduate Institute of Medical Education & Research, School of Public Health, 
      Chandigarh, India.
FAU - Virdi, Navkiran Kaur
AU  - Virdi NK
FAU - Lakshmi, P V M
AU  - Lakshmi PV
FAU - Garg, Renu
AU  - Garg R
FAU - Bhattacharya, Madhulekha
AU  - Bhattacharya M
FAU - Khera, Ajay
AU  - Khera A
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - India
TA  - Indian J Med Res
JT  - The Indian journal of medical research
JID - 0374701
SB  - IM
CIN - Indian J Med Res. 2010 Sep;132:245-7. PMID: 20847367
MH  - Female
MH  - HIV Infections/*epidemiology/*transmission
MH  - Humans
MH  - India/epidemiology
MH  - Infectious Disease Transmission, Vertical/*prevention & control
MH  - Mass Screening/*methods
MH  - Pregnancy
MH  - Prevalence
MH  - *Sentinel Surveillance
EDAT- 2010/09/18 06:00
MHDA- 2011/01/25 06:00
CRDT- 2010/09/18 06:00
PHST- 2010/09/18 06:00 [entrez]
PHST- 2010/09/18 06:00 [pubmed]
PHST- 2011/01/25 06:00 [medline]
PST - ppublish
SO  - Indian J Med Res. 2010 Sep;132:256-9.


PMID- 20847332
OWN - NLM
STAT- MEDLINE
DCOM- 20110208
LR  - 20151119
IS  - 0748-321X (Print)
IS  - 0748-321X (Linking)
VI  - 37
IP  - 3
DP  - 2010 Fall
TI  - Perceptions of veterinary faculty members regarding their responsibility and
      preparation to teach non-technical competencies.
PG  - 238-47
LID - 10.3138/jvme.37.3.238 [doi]
AB  - The development of non-technical competencies has become an important component
      of veterinary education. In this study, we determined faculty perspectives
      regarding their perceived involvement and ability in the cultivation of these
      competencies. A survey was administered to faculty members at five institutions. 
      Respondents were asked whether the competency should be taught in their own
      courses and how prepared they felt to teach and evaluate the competency.
      Responses were analyzed by participant institution, gender, terminal degree and
      year, discipline, rank, and teaching experience. More than 90% of faculty
      respondents reported a personal responsibility to teach or cultivate critical
      thinking skills, communication skills, self-development skills, and ethical
      skills, with more than 85% also agreeing to a role in skills such as
      interpersonal skills, creativity, and self-management. The lowest percentages
      were seen for crisis and incident management (64%) and business skills (56%).
      Perceived preparedness to teach and evaluate these competencies paralleled the
      preceding findings, especially for the four consensus competencies and
      self-management. Faculty preparedness was lowest for business skills. Junior
      faculty were somewhat less likely than others to perceive a responsibility to
      teach non-technical competencies; however, instructors were more prepared to
      teach and evaluate business skills than were other faculty. Institutional trends 
      were evident in faculty preparation. Although male faculty and non-DVM faculty
      tended to report a higher degree of preparedness, few differences reached
      statistical significance. Faculty perceptions of their responsibility to teach
      non-technical competencies vary by competency and parallel their perceived
      preparedness to teach and evaluate them.
FAU - Lane, India F
AU  - Lane IF
AD  - University of Tennessee College of Veterinary Medicine, Knoxville, TN 37996-4544,
      USA. ilane@utk.edu
FAU - Bogue, E Grady
AU  - Bogue EG
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - J Vet Med Educ
JT  - Journal of veterinary medical education
JID - 7610519
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Competency-Based Education
MH  - Education, Veterinary/*standards
MH  - Faculty/*statistics & numerical data
MH  - Female
MH  - Humans
MH  - Job Satisfaction
MH  - Male
MH  - Middle Aged
MH  - North America
MH  - Perception
MH  - *Professional Competence
MH  - Schools, Veterinary
MH  - Surveys and Questionnaires
EDAT- 2010/09/18 06:00
MHDA- 2011/02/09 06:00
CRDT- 2010/09/18 06:00
PHST- 2010/09/18 06:00 [entrez]
PHST- 2010/09/18 06:00 [pubmed]
PHST- 2011/02/09 06:00 [medline]
AID - 37/3/238 [pii]
AID - 10.3138/jvme.37.3.238 [doi]
PST - ppublish
SO  - J Vet Med Educ. 2010 Fall;37(3):238-47. doi: 10.3138/jvme.37.3.238.


PMID- 20847331
OWN - NLM
STAT- MEDLINE
DCOM- 20110208
LR  - 20220310
IS  - 0748-321X (Print)
IS  - 0748-321X (Linking)
VI  - 37
IP  - 3
DP  - 2010 Fall
TI  - Professional development training through the veterinary curriculum at the
      University of Minnesota.
PG  - 233-7
LID - 10.3138/jvme.37.3.233 [doi]
AB  - Veterinary education has traditionally focused on clinical skills. Success as a
      practicing veterinarian, however, also depends on good communication skills,
      emotional intelligence, and other "soft" skills that can lead to greater employee
      and employer satisfaction and increased practice revenue. The University of
      Minnesota has approached this curricular need by convening a task force and
      creating a series of courses aimed at improving leadership skills, teamwork, and 
      verbal and written communication; managing conflict; and understanding ethics and
      personal finance. This article describes the evolution and structure of these
      soft-skill classes and the challenges in securing faculty and student buy-in
      essential for success.
FAU - Kustritz, Margaret V Root
AU  - Kustritz MV
AD  - Department of Veterinary Clinical Sciences, College of Veterinary Medicine,
      University of Minnesota, St. Paul, MN 55108, USA. rootk001@umn.edu
FAU - Nault, Andre J
AU  - Nault AJ
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - J Vet Med Educ
JT  - Journal of veterinary medical education
JID - 7610519
SB  - IM
EIN - J Vet Med Educ. 2010 Winter;37(4):316
MH  - *Communication
MH  - *Curriculum
MH  - Education, Veterinary/*methods
MH  - Faculty
MH  - Humans
MH  - Interprofessional Relations
MH  - Minnesota
MH  - *Professional Competence
MH  - Professional-Patient Relations
MH  - Schools, Veterinary
MH  - Students, Health Occupations
EDAT- 2010/09/18 06:00
MHDA- 2011/02/09 06:00
CRDT- 2010/09/18 06:00
PHST- 2010/09/18 06:00 [entrez]
PHST- 2010/09/18 06:00 [pubmed]
PHST- 2011/02/09 06:00 [medline]
AID - 37/3/233 [pii]
AID - 10.3138/jvme.37.3.233 [doi]
PST - ppublish
SO  - J Vet Med Educ. 2010 Fall;37(3):233-7. doi: 10.3138/jvme.37.3.233.


PMID- 20847108
OWN - NLM
STAT- MEDLINE
DCOM- 20110929
LR  - 20110523
IS  - 1465-3648 (Electronic)
IS  - 0268-1153 (Linking)
VI  - 26
IP  - 3
DP  - 2011 Jun
TI  - Advancing biosocial pedagogy for HIV education.
PG  - 556-62
LID - 10.1093/her/cyq047 [doi]
AB  - This article develops the concept of biosocial pedagogy in HIV education for this
      era of expanding biomedical forms of HIV control. With reference to critical
      pedagogy and teaching and learning materials addressing HIV treatment and
      prevention, I explain how HIV education can problematize its own role in HIV
      control. I also discuss how educational practice can be informed by the ethical
      and political dilemmas that face people affected by HIV. I argue that through
      biosocially aware HIV pedagogy, individuals and communities can be assisted to
      act on the opportunities and drawbacks of biomedical HIV control.
FAU - Davis, Mark David McGregor
AU  - Davis MD
AD  - School of Political and Social Inquiry, Faculty of Arts, Monash University,
      Clayton, Victoria 3800, Australia. mark.davis@monash.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100916
PL  - England
TA  - Health Educ Res
JT  - Health education research
JID - 8608459
MH  - *Concept Formation
MH  - *Curriculum
MH  - *HIV Infections/drug therapy/prevention & control
MH  - *Health Education
MH  - Humans
MH  - Social Environment
MH  - Teaching Materials
EDAT- 2010/09/18 06:00
MHDA- 2011/10/01 06:00
CRDT- 2010/09/18 06:00
PHST- 2010/09/18 06:00 [entrez]
PHST- 2010/09/18 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - cyq047 [pii]
AID - 10.1093/her/cyq047 [doi]
PST - ppublish
SO  - Health Educ Res. 2011 Jun;26(3):556-62. doi: 10.1093/her/cyq047. Epub 2010 Sep
      16.


PMID- 20846906
OWN - NLM
STAT- MEDLINE
DCOM- 20110203
LR  - 20131121
IS  - 1471-5007 (Electronic)
IS  - 1471-4922 (Linking)
VI  - 27
IP  - 1
DP  - 2011 Jan
TI  - Consideration of ethics in primaquine therapy against malaria transmission.
PG  - 11-6
LID - 10.1016/j.pt.2010.08.005 [doi]
AB  - Millions of people receive primaquine against sexual plasmodia responsible for
      malaria transmission. These gametocytes cause no symptoms and do not threaten the
      host, but they infect mosquitoes and threaten the community. Primaquine causes
      hemolysis in the small minority of patients with glucose-6-phosphate
      dehydrogenase deficiency (G6PDd). Clinical studies in the 1950s demonstrated
      gametocytocidal primaquine to be safe without G6PDd screening. However, the
      evaluated G6PDd variant, African A-, represents mild sensitivity to primaquine.
      The view of primaquine as a safe gametocytocide thus rests largely upon
      observations from a G6PDd variant that is unlikely to challenge safety. The early
      clinical work does not seem to afford an adequate assessment of safety in G6PDd
      patients. Potential risk of harm without clinical benefit to the patient raises
      ethical questions that should be examined.
CI  - Copyright A(c) 2010 Elsevier Ltd. All rights reserved.
FAU - Baird, J Kevin
AU  - Baird JK
AD  - Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia. kbaird@eocru.org
FAU - Surjadjaja, Claudia
AU  - Surjadjaja C
LA  - eng
PT  - Journal Article
DEP - 20100916
PL  - England
TA  - Trends Parasitol
JT  - Trends in parasitology
JID - 100966034
RN  - 0 (Antimalarials)
RN  - EC 1.1.1.49 (Glucosephosphate Dehydrogenase)
RN  - MVR3634GX1 (Primaquine)
SB  - IM
MH  - Antimalarials/adverse effects/*therapeutic use
MH  - Erythrocytes/drug effects/enzymology/parasitology
MH  - Glucosephosphate Dehydrogenase/blood
MH  - Glucosephosphate Dehydrogenase Deficiency/*drug therapy/enzymology/parasitology
MH  - Humans
MH  - Malaria/*drug therapy/enzymology/transmission
MH  - Primaquine/adverse effects/*therapeutic use
MH  - Sexually Transmitted Diseases/*drug therapy/enzymology/parasitology
EDAT- 2010/09/18 06:00
MHDA- 2011/02/04 06:00
CRDT- 2010/09/18 06:00
PHST- 2010/07/15 00:00 [received]
PHST- 2010/08/23 00:00 [revised]
PHST- 2010/08/23 00:00 [accepted]
PHST- 2010/09/18 06:00 [entrez]
PHST- 2010/09/18 06:00 [pubmed]
PHST- 2011/02/04 06:00 [medline]
AID - S1471-4922(10)00176-5 [pii]
AID - 10.1016/j.pt.2010.08.005 [doi]
PST - ppublish
SO  - Trends Parasitol. 2011 Jan;27(1):11-6. doi: 10.1016/j.pt.2010.08.005. Epub 2010
      Sep 16.


PMID- 20846414
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211020
IS  - 1756-3305 (Electronic)
IS  - 1756-3305 (Linking)
VI  - 3
DP  - 2010 Sep 16
TI  - Potential negative impacts and low effectiveness in the use of African annual
      killifish in the biocontrol of aquatic mosquito larvae in temporary water bodies.
PG  - 89
LID - 10.1186/1756-3305-3-89 [doi]
AB  - Commentary and discussion on a recent paper promoting the use of Nothobranchius
      guentheri, a small African annual fish from the Island of Zanzibar as a tool to
      control mosquito larvae in temporary bodies of freshwater throughout Africa is
      presented.Arguments on major points; (1) expected low success of annual fish
      introductions, (2) low success of mosquito control in the field, (3) ecological
      threats, and (4) ethical issues are detailed.Despite serious problems with
      mosquito-borne diseases in tropical Africa and elsewhere, we encourage
      responsible means of biological control of parasite vectors. We show that
      effectiveness of Nothobranchius translocations is low (the previous attempts
      failed), likelihood of effective mosquito larvae control under field condition is
      negligible and ecological threats from Nothobranchius translocations from within 
      and outside the naturally occurring range are serious. We advocate against the
      proposed next step of the project, i.e. field trials in Tanzania.
FAU - Reichard, Martin
AU  - Reichard M
AD  - Institute of Vertebrate Biology, Academy of Sciences of the Czech Republic,
      Kvetna 8, 603 65 Brno, Czech Republic. reichard@ivb.cz.
FAU - Watters, Brian R
AU  - Watters BR
FAU - Wildekamp, Rudolf H
AU  - Wildekamp RH
FAU - Sonnenberg, Rainer
AU  - Sonnenberg R
FAU - Nagy, Bela
AU  - Nagy B
FAU - Polacik, Matej
AU  - Polacik M
FAU - Valdesalici, Stefano
AU  - Valdesalici S
FAU - Cellerino, Alessandro
AU  - Cellerino A
FAU - Cooper, Barry J
AU  - Cooper BJ
FAU - Hengstler, Holger
AU  - Hengstler H
FAU - Rosenstock, John
AU  - Rosenstock J
FAU - Sainthouse, Ian
AU  - Sainthouse I
LA  - eng
PT  - Journal Article
DEP - 20100916
PL  - England
TA  - Parasit Vectors
JT  - Parasites & vectors
JID - 101462774
PMC - PMC2945331
EDAT- 2010/09/18 06:00
MHDA- 2010/09/18 06:01
CRDT- 2010/09/18 06:00
PHST- 2010/09/09 00:00 [received]
PHST- 2010/09/16 00:00 [accepted]
PHST- 2010/09/18 06:00 [entrez]
PHST- 2010/09/18 06:00 [pubmed]
PHST- 2010/09/18 06:01 [medline]
AID - 1756-3305-3-89 [pii]
AID - 10.1186/1756-3305-3-89 [doi]
PST - epublish
SO  - Parasit Vectors. 2010 Sep 16;3:89. doi: 10.1186/1756-3305-3-89.


PMID- 20845473
OWN - NLM
STAT- MEDLINE
DCOM- 20110315
LR  - 20211020
IS  - 1549-4918 (Electronic)
IS  - 1066-5099 (Linking)
VI  - 28
IP  - 11
DP  - 2010 Nov
TI  - Law, ethics, religion, and clinical translation in the 21st century--a discussion
      with Andrew Webster.
PG  - 1915-7
LID - 10.1002/stem.519 [doi]
FAU - Lako, Majlinda
AU  - Lako M
AD  - Institute of Human Genetics and NESCI, Newcastle University, International Centre
      for Life, Central Parkway, Newcastle NE1 3BZ, United Kingdom.
FAU - Trounson, Alan O
AU  - Trounson AO
FAU - Daher, Susan
AU  - Daher S
LA  - eng
PT  - Interview
PL  - England
TA  - Stem Cells
JT  - Stem cells (Dayton, Ohio)
JID - 9304532
SB  - IM
MH  - *Religion
MH  - Stem Cell Research/*ethics/*legislation & jurisprudence
PMC - PMC3003907
EDAT- 2010/09/17 06:00
MHDA- 2011/03/16 06:00
CRDT- 2010/09/17 06:00
PHST- 2010/09/17 06:00 [entrez]
PHST- 2010/09/17 06:00 [pubmed]
PHST- 2011/03/16 06:00 [medline]
AID - 10.1002/stem.519 [doi]
PST - ppublish
SO  - Stem Cells. 2010 Nov;28(11):1915-7. doi: 10.1002/stem.519.


PMID- 20844979
OWN - NLM
STAT- MEDLINE
DCOM- 20120330
LR  - 20110930
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 17
IP  - 3
DP  - 2011 Sep
TI  - The Nazi engineers: reflections on technological ethics in hell.
PG  - 571-82
LID - 10.1007/s11948-010-9229-z [doi]
AB  - Engineers, architects, and other technological professionals designed the
      genocidal death machines of the Third Reich. The death camp operations were
      highly efficient, so these technological professionals knew what they were doing:
      they were, so to speak, good engineers. As an educator at a technological
      university, I need to explain to my students-future engineers and architects-the 
      motivations and ethical reasoning of the technological professionals of the Third
      Reich. I need to educate my students in the ethical practices of this hellish
      regime so that they can avoid the kind of ethical justifications used by the Nazi
      engineers. In their own professional lives, my former students should not only be
      good engineers in a technical sense, but good engineers in a moral sense. In this
      essay, I examine several arguments about the ethical judgments of professionals
      in Nazi Germany, and attempt a synthesis that can provide a lesson for
      contemporary engineers and other technological professionals. How does an
      engineer avoid the error of the Nazi engineers in their embrace of an evil
      ideology underlying their technological creations? How does an engineer know that
      the values he embodies through his technological products are good values that
      will lead to a better world? This last question, I believe, is the fundamental
      issue for the understanding of engineering ethics.
FAU - Katz, Eric
AU  - Katz E
AD  - Department of Humanities, New Jersey Institute of Technology, Newark, NJ 07101,
      USA. ekatzhome@aol.com
LA  - eng
PT  - Historical Article
PT  - Journal Article
DEP - 20100916
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Engineering/ethics/*history
MH  - Ethics, Professional/education
MH  - Germany
MH  - History, 20th Century
MH  - Homicide/ethics/*history
MH  - Humans
MH  - National Socialism/*history
MH  - *Social Responsibility
MH  - Social Values/*history
EDAT- 2010/09/17 06:00
MHDA- 2012/03/31 06:00
CRDT- 2010/09/17 06:00
PHST- 2010/05/19 00:00 [received]
PHST- 2010/08/31 00:00 [accepted]
PHST- 2010/09/17 06:00 [entrez]
PHST- 2010/09/17 06:00 [pubmed]
PHST- 2012/03/31 06:00 [medline]
AID - 10.1007/s11948-010-9229-z [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2011 Sep;17(3):571-82. doi: 10.1007/s11948-010-9229-z. Epub 2010 
      Sep 16.


PMID- 20843994
OWN - NLM
STAT- MEDLINE
DCOM- 20110110
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 257
IP  - 3
DP  - 2010 Dec
TI  - Selective atrophy of the middle hepatic venous drainage area in hepatitis
      C-related cirrhotic liver: morphometric study by using multidetector CT.
PG  - 705-14
LID - 10.1148/radiol.10100468 [doi]
AB  - PURPOSE: To retrospectively analyze the morphologic changes of hepatitis
      C-related cirrhosis, which commonly show macronodular cirrhosis, in relation to
      the portal venous supply and hepatic venous drainage, by using multidetector
      computed tomographic volumetry. MATERIALS AND METHODS: Institutional ethics
      committee approval and informed consent were obtained. The volume of the entire
      liver, each portal segment, and hepatic venous drainage area with the respective 
      proportion relative to the entire liver and the volume of hepatic area with the
      respective proportion relative to the anterior segment of the right lobe were
      measured in 74 patients without cirrhosis and with normal liver function and in
      64 patients with cirrhosis classified as Child-Pugh class A and in 68 with that
      classified as Child-Pugh class B. The diameter and length of each hepatic vein
      were measured in normal liver. All measurements were statistically analyzed by
      using the Kruskal-Wallis test, and multiple comparisons were made by using a
      Bonferroni correction (P < .05). RESULTS: The entire liver volume was
      significantly smaller in patients with Child-Pugh class B cirrhosis (P = .002),
      whereas there was no significant difference in volume between the normal liver
      and the liver with Child-Pugh class A cirrhosis (P > .99). Middle hepatic venous 
      (MHV) drainage area revealed significant atrophy in cirrhosis (P < .0001), more
      markedly in Child-Pugh class B. The right hepatic venous (RHV) and left hepatic
      venous drainage areas showed significant hypertrophy in cirrhosis (P < .0001).
      The anterior and medial segments showed significant atrophy (P < .0001), and the 
      lateral and posterior segments and caudate lobe showed significant hypertrophy in
      cirrhosis (P < .05). In the anterior segment, the MHV drainage area showed
      significant atrophy (P < .0001), and the RHV drainage area demonstrated relative 
      hypertrophy in cirrhosis, more definitely in Child-Pugh class B. The diameter of 
      MHV was significantly the smallest (P < .0001), and the length of MHV was
      relatively longer in normal livers. CONCLUSION: The morphologic changes in
      hepatitis C-related cirrhosis (mainly macronodular cirrhosis) were attributed to 
      a selective volume reduction of the MHV drainage area and relative enlargement of
      the other areas.
CI  - (c) RSNA, 2010.
FAU - Ozaki, Kumi
AU  - Ozaki K
AD  - Department of Radiology, Graduate School of Medical Science, Kanazawa University,
      13-1 Takara-machi, Kanazawa 920-8641, Japan. ozaki@rad.m.kanazawa-u.ac.jp
FAU - Matsui, Osamu
AU  - Matsui O
FAU - Kobayashi, Satoshi
AU  - Kobayashi S
FAU - Sanada, Junichiro
AU  - Sanada J
FAU - Koda, Wataru
AU  - Koda W
FAU - Minami, Tetsuya
AU  - Minami T
FAU - Kawai, Keiichi
AU  - Kawai K
FAU - Gabata, Toshifumi
AU  - Gabata T
LA  - eng
PT  - Journal Article
DEP - 20100915
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - 17E17JBP8L (iomeprol)
RN  - JR13W81H44 (Iopamidol)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Atrophy
MH  - Chi-Square Distribution
MH  - Contrast Media/administration & dosage
MH  - Female
MH  - Hepatic Veins/*diagnostic imaging/*physiopathology
MH  - Hepatitis C/*complications
MH  - Humans
MH  - Iopamidol/administration & dosage/analogs & derivatives
MH  - Liver Cirrhosis/*diagnostic imaging/*physiopathology/*virology
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Statistics, Nonparametric
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2010/09/17 06:00
MHDA- 2011/01/11 06:00
CRDT- 2010/09/17 06:00
PHST- 2010/09/17 06:00 [entrez]
PHST- 2010/09/17 06:00 [pubmed]
PHST- 2011/01/11 06:00 [medline]
AID - radiol.10100468 [pii]
AID - 10.1148/radiol.10100468 [doi]
PST - ppublish
SO  - Radiology. 2010 Dec;257(3):705-14. doi: 10.1148/radiol.10100468. Epub 2010 Sep
      15.


PMID- 20843993
OWN - NLM
STAT- MEDLINE
DCOM- 20110110
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 257
IP  - 3
DP  - 2010 Dec
TI  - Assessment of non-small cell lung cancer perfusion: pathologic-CT correlation in 
      15 patients.
PG  - 863-71
LID - 10.1148/radiol.10100181 [doi]
AB  - PURPOSE: To assess tumor perfusion with multi-detector row computed tomography
      (CT) in patients with non-small cell lung carcinoma and to correlate CT findings 
      with pathologic results. MATERIALS AND METHODS: This study was approved by the
      local Ethics Committee, and all patients provided written informed consent, which
      included information on the radiation exposure at the CT examinations. Fifteen
      consecutive patients (mean age, 60.5 years +/- 7.7 [standard deviation]),
      including 14 men (mean age, 59.9 years +/- 7.5) and one woman (age, 70 years)
      with histologically proved non-small cell lung carcinoma were prospectively
      enrolled. Overall, pathologic-CT correlations were examined in 31 focal tumoral
      zones. Comparative analysis was performed by using the chi(2) or the Fisher exact
      test for categoric data. For numeric data, group comparisons were performed by
      using the Mann-Whitney test. RESULTS: Whole-tumor coverage (mean height, 4.3 cm
      +/- 2.1) was possible in all patients with generation of colored parametric maps 
      of volume transfer constant (K(trans)) and blood volume (BV) by using Patlak
      analysis. Of the 12 areas that showed high BV, 10 (83%) had a high K(trans); in
      all 12 cases, the vascular score was high, confirming the presence of numerous
      tumoral vessels. Nineteen areas showed low BV; when observed concurrently with a 
      high K(trans) (seven of 19), the mean vessel number per area was significantly
      higher than that seen in areas with low BV and low K(trans) (12 of 19) (P =
      .038), suggestive of tumoral vessels associated with high interstitial pressure. 
      CONCLUSION: Whole-tumor perfusion analysis is technically feasible with
      64-detector row CT, with two patterns suggestive of high tumoral vascularity.
      SUPPLEMENTAL MATERIAL:
      http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.10100181/-/DC1.
CI  - (c) RSNA, 2010
FAU - Tacelli, Nunzia
AU  - Tacelli N
AD  - Department of Thoracic Imaging and Pulmonary at Hospital Calmette, University
      Lille Nord de France (EA 2694 Boulevard Jules Leclercq, 59037 Lille, France.
FAU - Remy-Jardin, Martine
AU  - Remy-Jardin M
FAU - Copin, Marie-Christine
AU  - Copin MC
FAU - Scherpereel, Arnaud
AU  - Scherpereel A
FAU - Mensier, Eric
AU  - Mensier E
FAU - Jaillard, Sophie
AU  - Jaillard S
FAU - Lafitte, Jean-Jacques
AU  - Lafitte JJ
FAU - Klotz, Ernst
AU  - Klotz E
FAU - Duhamel, Alain
AU  - Duhamel A
FAU - Remy, Jacques
AU  - Remy J
LA  - eng
PT  - Journal Article
DEP - 20100915
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - 4419T9MX03 (Iohexol)
RN  - 712BAC33MZ (iopromide)
SB  - IM
CIN - Radiology. 2011 May;259(2):613; author reply 613-4. PMID: 21502398
MH  - Aged
MH  - Carcinoma, Non-Small-Cell Lung/blood supply/*diagnostic imaging/pathology
MH  - Chi-Square Distribution
MH  - Contrast Media
MH  - Female
MH  - Humans
MH  - Iohexol/analogs & derivatives
MH  - Lung Neoplasms/blood supply/*diagnostic imaging/pathology
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Statistics, Nonparametric
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2010/09/17 06:00
MHDA- 2011/01/11 06:00
CRDT- 2010/09/17 06:00
PHST- 2010/09/17 06:00 [entrez]
PHST- 2010/09/17 06:00 [pubmed]
PHST- 2011/01/11 06:00 [medline]
AID - radiol.10100181 [pii]
AID - 10.1148/radiol.10100181 [doi]
PST - ppublish
SO  - Radiology. 2010 Dec;257(3):863-71. doi: 10.1148/radiol.10100181. Epub 2010 Sep
      15.


PMID- 20843991
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20220408
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 257
IP  - 2
DP  - 2010 Nov
TI  - Quantitative MR imaging of brain iron: a postmortem validation study.
PG  - 455-62
LID - 10.1148/radiol.10100495 [doi]
AB  - PURPOSE: To investigate the relationship between transverse relaxation rates R2
      and R2*, the most frequently used surrogate markers for iron in brain tissue, and
      chemically determined iron concentrations. MATERIALS AND METHODS: This study was 
      approved by the local ethics committee, and informed consent was obtained from
      each individual's next of kin. Quantitative magnetic resonance (MR) imaging was
      performed at 3.0 T in seven human postmortem brains in situ (age range at death, 
      38-81 years). Following brain extraction, iron concentrations were determined
      with inductively coupled plasma mass spectrometry in prespecified gray and white 
      matter regions and correlated with R2 and R2* by using linear regression
      analysis. Hemispheric differences were tested with paired t tests. RESULTS: The
      highest iron concentrations were found in the globus pallidus (mean +/- standard 
      deviation, 205 mg/kg wet mass +/- 32), followed by the putamen (mean, 153 mg/kg
      wet mass +/- 29), caudate nucleus (mean, 92 mg/kg wet mass +/- 15), thalamus
      (mean, 49 mg/kg wet mass +/- 11), and white matter regions. When all tissue
      samples were considered, transverse relaxation rates showed a strong linear
      correlation with iron concentration throughout the brain (r(2) = 0.67 for R2,
      r(2) = 0.90 for R2*; P < .001). In white matter structures, only R2* showed a
      linear correlation with iron concentration. Chemical analysis revealed
      significantly higher iron concentrations in the left hemisphere than in the right
      hemisphere, a finding that was not reflected in the relaxation rates. CONCLUSION:
      Because of their strong linear correlation with iron concentration, both R2 and
      R2* can be used to measure iron deposition in the brain. Because R2* is more
      sensitive than R2 to variations in brain iron concentration and can detect
      differences in white matter, it is the preferred parameter for the assessment of 
      iron concentration in vivo.
CI  - (c) RSNA, 2010.
FAU - Langkammer, Christian
AU  - Langkammer C
AD  - Department of Neurology and Division of Neuroradiology, Medical University of
      Graz, Auenbruggerplatz 22, 8036 Graz, Austria.
FAU - Krebs, Nikolaus
AU  - Krebs N
FAU - Goessler, Walter
AU  - Goessler W
FAU - Scheurer, Eva
AU  - Scheurer E
FAU - Ebner, Franz
AU  - Ebner F
FAU - Yen, Kathrin
AU  - Yen K
FAU - Fazekas, Franz
AU  - Fazekas F
FAU - Ropele, Stefan
AU  - Ropele S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100915
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - E1UOL152H7 (Iron)
SB  - IM
EIN - Radiology. 2011 Mar;258(3):962
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Brain Chemistry
MH  - Cadaver
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Iron/*analysis
MH  - Magnetic Resonance Imaging/*methods
MH  - Mass Spectrometry/instrumentation
MH  - Middle Aged
MH  - Regression Analysis
MH  - Sensitivity and Specificity
MH  - Statistics, Nonparametric
EDAT- 2010/09/17 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/09/17 06:00
PHST- 2010/09/17 06:00 [entrez]
PHST- 2010/09/17 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - radiol.10100495 [pii]
AID - 10.1148/radiol.10100495 [doi]
PST - ppublish
SO  - Radiology. 2010 Nov;257(2):455-62. doi: 10.1148/radiol.10100495. Epub 2010 Sep
      15.


PMID- 20843885
OWN - NLM
STAT- MEDLINE
DCOM- 20101201
LR  - 20220331
IS  - 1544-1717 (Electronic)
IS  - 1544-1709 (Linking)
VI  - 8
IP  - 5
DP  - 2010 Sep-Oct
TI  - Ethics of health research in communities: perspectives from the southwestern
      United States.
PG  - 433-9
LID - 10.1370/afm.1138 [doi]
AB  - PURPOSE: The increasing attention paid to community-based research highlights the
      question of whether human research protections focused on the individual are
      adequate to safeguard communities. We conducted a study to explore how community 
      members perceive low-risk health research, the adequacy of human research
      protection processes, and the ethical conduct of community-based research.
      METHODS: Eighteen focus groups were conducted among rural and urban Hispanic and 
      Native American communities in New Mexico using a semistructured guide. Group
      transcriptions were analyzed using iterative readings and coding, with review of 
      the analytic summary by group members. RESULTS: Although participants recognized 
      the value of health research, many also identified several adverse effects of
      research in their communities, including social (community and individual
      labeling, stigmatization, and discrimination) and economic (community job losses,
      increased insurance rates, and loss of community income). A lack of community
      beneficence was emphasized by participants who spoke of researchers who fail to
      communicate results adequately or assist with follow-through. Many group members 
      did not believe current human research and data privacy processes were adequate
      to protect or assist communities. CONCLUSIONS: Ethical review of community-based 
      health research should apply the Belmont principles to communities. Researchers
      should adopt additional approaches to community-based research by engaging
      communities as active partners throughout the research process, focusing on
      community priorities, and taking extra precautions to assure individual and
      community privacy. Plans for meaningful dissemination of results to communities
      should be part of the research design.
FAU - Williams, Robert L
AU  - Williams RL
AD  - Department of Family and Community Medicine, University of New Mexico,
      Albuquerque, New Mexico 87131, USA. rlwilliams@salud.unm.edu
FAU - Willging, Cathleen E
AU  - Willging CE
FAU - Quintero, Gilbert
AU  - Quintero G
FAU - Kalishman, Summers
AU  - Kalishman S
FAU - Sussman, Andrew L
AU  - Sussman AL
FAU - Freeman, William L
AU  - Freeman WL
CN  - RIOS Net Members
LA  - eng
GR  - 1 R03 HS013208/HS/AHRQ HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Ann Fam Med
JT  - Annals of family medicine
JID - 101167762
SB  - IM
MH  - Communication
MH  - Community-Based Participatory Research/*ethics
MH  - Confidentiality/*ethics
MH  - Female
MH  - Hispanic or Latino
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Indians, North American
MH  - Male
MH  - New Mexico
MH  - Privacy
MH  - Qualitative Research
PMC - PMC2939419
EDAT- 2010/09/17 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/09/17 06:00
PHST- 2010/09/17 06:00 [entrez]
PHST- 2010/09/17 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 8/5/433 [pii]
AID - 10.1370/afm.1138 [doi]
PST - ppublish
SO  - Ann Fam Med. 2010 Sep-Oct;8(5):433-9. doi: 10.1370/afm.1138.


PMID- 20843672
OWN - NLM
STAT- MEDLINE
DCOM- 20110323
LR  - 20101104
IS  - 1769-664X (Electronic)
IS  - 0929-693X (Linking)
VI  - 17
IP  - 11
DP  - 2010 Nov
TI  - [New technologies for the human genome exploration].
PG  - 1605-8
LID - 10.1016/j.arcped.2010.06.015 [doi]
AB  - Human genome consists of 23 pairs of chromosomes, bearing our genetic
      information. Basically, there are two main approaches to analyse our genome:
      molecular genetics with direct sequencing, which detects genic mutations, and
      cytogenetics with the karyotype, which detects number and structural chromosomal 
      anomalies. The main limitation of the karyotype is its level of resolution: it
      cannot detect abnormalities smaller than five megabases. The combined use of
      cytogenetics and molecular genetics has allowed the development of several new
      techniques that provide a comprehensive analysis of the genome with a very high
      level of resolution. Currently, the most efficient of those techniques is
      comparative genomic hybridization on microarray (array CGH), which already has
      diagnostic applications. However, those new methods are challenging to interpret 
      and they raise ethical problems. Therefore they must be cautiously supervised.
CI  - Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
FAU - Keren, B
AU  - Keren B
AD  - Departement de genetique, hopital de la Pitie-Salpetriere, Assistance
      publique-Hopitaux de Paris, 47-83, boulevard de l'hopital, 75013 Paris, France.
FAU - Schluth-Bolard, C
AU  - Schluth-Bolard C
FAU - Egea, G
AU  - Egea G
FAU - Sanlaville, D
AU  - Sanlaville D
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Nouvelles methodes d'analyse globale du genome humain.
DEP - 20100916
PL  - France
TA  - Arch Pediatr
JT  - Archives de pediatrie : organe officiel de la Societe francaise de pediatrie
JID - 9421356
SB  - IM
MH  - Chromosome Disorders/diagnosis/genetics
MH  - Comparative Genomic Hybridization/methods
MH  - Genetic Testing/methods
MH  - Genome, Human/*genetics
MH  - Humans
MH  - Karyotyping/methods
MH  - Molecular Diagnostic Techniques/*methods
MH  - Mutation/genetics
MH  - Neoplasms/genetics
MH  - Oligonucleotide Array Sequence Analysis/methods
MH  - Reproducibility of Results
EDAT- 2010/09/17 06:00
MHDA- 2011/03/24 06:00
CRDT- 2010/09/17 06:00
PHST- 2009/10/01 00:00 [received]
PHST- 2010/06/10 00:00 [revised]
PHST- 2010/06/16 00:00 [accepted]
PHST- 2010/09/17 06:00 [entrez]
PHST- 2010/09/17 06:00 [pubmed]
PHST- 2011/03/24 06:00 [medline]
AID - S0929-693X(10)00260-5 [pii]
AID - 10.1016/j.arcped.2010.06.015 [doi]
PST - ppublish
SO  - Arch Pediatr. 2010 Nov;17(11):1605-8. doi: 10.1016/j.arcped.2010.06.015. Epub
      2010 Sep 16.


PMID- 20843327
OWN - NLM
STAT- MEDLINE
DCOM- 20101021
LR  - 20211020
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 11
DP  - 2010 Sep 15
TI  - End-of-life discontinuation of destination therapy with cardiac and ventilatory
      support medical devices: physician-assisted death or allowing the patient to die?
PG  - 15
LID - 10.1186/1472-6939-11-15 [doi]
AB  - BACKGROUND: Bioethics and law distinguish between the practices of
      "physician-assisted death" and "allowing the patient to die." DISCUSSION:
      Advances in biotechnology have allowed medical devices to be used as destination 
      therapy that are designed for the permanent support of cardiac function and/or
      respiration after irreversible loss of these spontaneous vital functions. For
      permanent support of cardiac function, single ventricle or biventricular
      mechanical assist devices and total artificial hearts are implanted in the body. 
      Mechanical ventilators extrinsic to the body are used for permanent support of
      respiration. Clinical studies have shown that destination therapy with
      ventricular assist devices improves patient survival compared to medical
      management, but at the cost of a substantial alteration in end-of-life
      trajectories. The moral and legal assessment of the appropriateness and
      permissibility of complying with a patient's request to electively discontinue
      destination therapy in a life-terminating act in non-futile situations has
      generated controversy. Some argue that complying with this request is ethically
      justified because patients have the right to request withdrawal of unwanted
      treatment and be allowed to die of preexisting disease. Other commentators reject
      the argument that acceding to an elective request for death by discontinuing
      destination therapy is 'allowing a patient to die' because of serious flaws in
      interpreting the intention, causation, and moral responsibility of the ensuing
      death. SUMMARY: Destination therapy with cardiac and/or ventilatory medical
      devices replaces native physiological functions and successfully treats a
      preexisting disease. We posit that discontinuing cardiac and/or ventilatory
      support at the request of a patient or surrogate can be viewed as allowing the
      patient to die if--and only if--concurrent lethal pathophysiological conditions
      are present that are unrelated to those functions already supported by medical
      devices in destination therapy. In all other cases, compliance with a patient's
      request constitutes physician-assisted death because of the pathophysiology
      induced by the turning off of these medical devices, as well as the intention,
      causation, and moral responsibility of the ensuing death. The distinction between
      allowing the patient to die and physician-assisted death is pivotal to the moral 
      and legal status of elective requests for death by discontinuing destination
      cardiac and/or ventilatory medical devices in patients who are not imminently
      dying. This distinction also represents essential information that must be
      disclosed to patients and surrogates in advance of consent to this type of
      therapy.
FAU - Rady, Mohamed Y
AU  - Rady MY
AD  - Department of Critical Care Medicine, Mayo Clinic Hospital, Mayo Clinic, 5777
      East Mayo Boulevard, Phoenix, Arizona 85054, USA. rady.mohamed@mayo.edu
FAU - Verheijde, Joseph L
AU  - Verheijde JL
LA  - eng
PT  - Journal Article
PT  - Retracted Publication
DEP - 20100915
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
RIN - BMC Med Ethics. 2010;11:20. PMID: 21176130
MH  - Causality
MH  - Decision Making/ethics
MH  - Ethical Analysis
MH  - Ethics, Clinical
MH  - Ethics, Medical
MH  - Euthanasia, Active/*ethics
MH  - Euthanasia, Passive/*ethics
MH  - *Heart-Assist Devices
MH  - Humans
MH  - Informed Consent/ethics
MH  - Intention
MH  - Medical Futility/ethics
MH  - *Moral Obligations
MH  - Physicians/*ethics
MH  - *Respiration, Artificial
MH  - Suicide, Assisted/*ethics/*legislation & jurisprudence
MH  - Withholding Treatment/*ethics
PMC - PMC2949779
EDAT- 2010/09/17 06:00
MHDA- 2010/10/22 06:00
CRDT- 2010/09/17 06:00
PHST- 2010/03/29 00:00 [received]
PHST- 2010/09/15 00:00 [accepted]
PHST- 2010/09/17 06:00 [entrez]
PHST- 2010/09/17 06:00 [pubmed]
PHST- 2010/10/22 06:00 [medline]
AID - 1472-6939-11-15 [pii]
AID - 10.1186/1472-6939-11-15 [doi]
PST - epublish
SO  - BMC Med Ethics. 2010 Sep 15;11:15. doi: 10.1186/1472-6939-11-15.


PMID- 20842912
OWN - NLM
STAT- MEDLINE
DCOM- 20101109
LR  - 20100916
IS  - 0042-773X (Print)
IS  - 0042-773X (Linking)
VI  - 56
IP  - 7
DP  - 2010 Jul
TI  - Survival and quality of life in burns.
PG  - 681-5
AB  - Advances in medical technology and practices have been associated with increasing
      medical specialization, but they have developed at a price. This price has
      included not only enormous financial costs, but the additional cost of
      dehumanized patient care, diminished confidence in the medical staff and,
      consequently, human suffering. Burn injuries are catastrophic in scope and
      require specialized, intensive and prolonged treatment from which ensure ethical 
      and psychological problems often complicated by many individual factors. Some of 
      them arising from the Code of Patients Rights not only in the Czech Republic and 
      contribute to DNR decisions (do-not-resuscitate). Not only "Quantity" of life but
      also "Quality" of life should be considered, particularly in burns. Critical
      factor is age. In old patients more sophisticated medical knowledge and practice 
      may actually contribute to suffering. At any age scarring represents a special
      type of disfigurement. The "burn image" is more likely to evoke public avoidance 
      than sympathy. The non handicapped by their negative attitudes help create and
      perpetuate the handicap and the consequent burden of suffering in burn patients.
FAU - Konigova, R
AU  - Konigova R
AD  - Prague Burn Centre, 3rd Medical Faculty Charles University and Teaching Hospital 
      Kralovske Vinohrady Prague. burnsec@fnkv.cz
LA  - eng
PT  - Journal Article
PL  - Czech Republic
TA  - Vnitr Lek
JT  - Vnitrni lekarstvi
JID - 0413602
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Burns/pathology/*surgery
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Male
MH  - Medical Futility
MH  - *Quality of Life
MH  - Resuscitation Orders
EDAT- 2010/09/17 06:00
MHDA- 2010/11/10 06:00
CRDT- 2010/09/17 06:00
PHST- 2010/09/17 06:00 [entrez]
PHST- 2010/09/17 06:00 [pubmed]
PHST- 2010/11/10 06:00 [medline]
PST - ppublish
SO  - Vnitr Lek. 2010 Jul;56(7):681-5.


PMID- 20842612
OWN - NLM
STAT- MEDLINE
DCOM- 20100930
LR  - 20100915
IS  - 1439-4413 (Electronic)
IS  - 0012-0472 (Linking)
VI  - 135
IP  - 38
DP  - 2010 Sep
TI  - [Ethical insolvency--losing medical identity in the DRG era].
PG  - 1881-2; author reply 1882
LID - 10.1055/s-0030-1263334 [doi]
FAU - Kobberling, J
AU  - Kobberling J
FAU - Schroeders, N von
AU  - Schroeders Nv
LA  - ger
PT  - Comment
PT  - Letter
TT  - Ethische Insolvenz? Vom Verlust medizinischer Identitat im DRG-Zeitalter.
DEP - 20100914
PL  - Germany
TA  - Dtsch Med Wochenschr
JT  - Deutsche medizinische Wochenschrift (1946)
JID - 0006723
SB  - IM
CON - Dtsch Med Wochenschr. 2010 Apr;135(16):819-21. PMID: 20391316
MH  - *Attitude of Health Personnel
MH  - Cost Control/ethics
MH  - Diagnosis-Related Groups/*ethics
MH  - *Ethics, Medical
MH  - Fee Schedules
MH  - Germany
MH  - Humans
MH  - Length of Stay
MH  - National Health Programs/*ethics
MH  - Quality Assurance, Health Care
MH  - Reimbursement Mechanisms/*ethics
EDAT- 2010/09/16 06:00
MHDA- 2010/10/01 06:00
CRDT- 2010/09/16 06:00
PHST- 2010/09/16 06:00 [entrez]
PHST- 2010/09/16 06:00 [pubmed]
PHST- 2010/10/01 06:00 [medline]
AID - 10.1055/s-0030-1263334 [doi]
PST - ppublish
SO  - Dtsch Med Wochenschr. 2010 Sep;135(38):1881-2; author reply 1882. doi:
      10.1055/s-0030-1263334. Epub 2010 Sep 14.


PMID- 20841693
OWN - NLM
STAT- MEDLINE
DCOM- 20101231
LR  - 20100915
IS  - 0926-9630 (Print)
IS  - 0926-9630 (Linking)
VI  - 160
IP  - Pt 1
DP  - 2010
TI  - Conceptualization of an electronic system for documentation of nursing diagnosis,
      outcomes, and intervention.
PG  - 279-83
AB  - Electronic nursing documentation constitutes technical, scientific, legal, and
      ethical documents. The objective of this study was to develop an electronic
      nursing documentation system. The system was developed in four phases
      (conceptualization, detailing, prototype building, implementation), and the
      knowledge base was based on domains and classes according to the NANDA-I, NIC,
      and NOC unified framework. The result is an electronic system
      (PROCEnf--USP--Nursing Process Electronic Documentation System of the University 
      of Sao Paulo) which allows documenting nursing process generating reports of
      nursing process, besides supporting decisions on nursing diagnosis, expected
      outcomes, and interventions. Integration of different fields of knowledge, as
      well as the institutional feature of valuing continuous theoretical and practical
      improvement of nursing process were factors of success of this technological
      project.
FAU - Peres, Heloisa Helena Ciqueto
AU  - Peres HH
AD  - Department of Professional Orientation, USP Nursing School, Hospital
      Universitario de Sao Paulo. hhcperes@usp.br
FAU - de Almeida Lopes Monteiro da Cruz, Dina
AU  - de Almeida Lopes Monteiro da Cruz D
FAU - Lima, Antonio Fernandes Costa
AU  - Lima AF
FAU - Gaidzinski, Raquel Rapone
AU  - Gaidzinski RR
FAU - Ortiz, Diley Cardoso Franco
AU  - Ortiz DC
FAU - Mendes e Trindade, Michelle
AU  - Mendes e Trindade M
FAU - Tsukamoto, Rosangela
AU  - Tsukamoto R
FAU - Batista de Oliveira, Neurilene
AU  - Batista de Oliveira N
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Stud Health Technol Inform
JT  - Studies in health technology and informatics
JID - 9214582
MH  - Brazil
MH  - Clinical Laboratory Information Systems/*organization & administration
MH  - Documentation/*methods
MH  - Electronic Health Records
MH  - Hospital Information Systems/*organization & administration
MH  - *Models, Organizational
MH  - Nursing Diagnosis/*methods/*organization & administration
MH  - Nursing Informatics/*organization & administration
EDAT- 2010/09/16 06:00
MHDA- 2011/01/01 06:00
CRDT- 2010/09/16 06:00
PHST- 2010/09/16 06:00 [entrez]
PHST- 2010/09/16 06:00 [pubmed]
PHST- 2011/01/01 06:00 [medline]
PST - ppublish
SO  - Stud Health Technol Inform. 2010;160(Pt 1):279-83.


PMID- 20840749
OWN - NLM
STAT- MEDLINE
DCOM- 20110203
LR  - 20211020
IS  - 1471-2407 (Electronic)
IS  - 1471-2407 (Linking)
VI  - 10
DP  - 2010 Sep 14
TI  - PGF2alpha-F-prostanoid receptor signalling via ADAMTS1 modulates epithelial cell 
      invasion and endothelial cell function in endometrial cancer.
PG  - 488
LID - 10.1186/1471-2407-10-488 [doi]
AB  - BACKGROUND: An increase in cancer cell invasion and microvascular density is
      associated with a poorer prognosis for patients with endometrial cancer. In
      endometrial adenocarcinoma F-prostanoid (FP) receptor expression is elevated,
      along with its ligand prostaglandin (PG)F2alpha, where it regulates expression
      and secretion of a host of growth factors and chemokines involved in
      tumorigenesis. This study investigates the expression, regulation and role of a
      disintegrin and metalloproteinase with thrombospondin repeat 1 (ADAMTS1) in
      endometrial adenocarcinoma cells by PGF2alpha via the FP receptor. METHODS: Human
      endometrium and adenocarcinoma tissues were obtained in accordance with Lothian
      Research Ethics Committee guidance with informed patient consent. Expression of
      ADAMTS1 mRNA and protein in tissues was determined by quantitative RT-PCR
      analysis and immunohistochemistry. Signal transduction pathways regulating
      ADAMTS1 expression in Ishikawa cells stably expressing the FP receptor to levels 
      seen in endometrial cancer (FPS cells) were determined by quantitative RT-PCR
      analysis. In vitro invasion and proliferation assays were performed with FPS
      cells and human umbilical vein endothelial cells (HUVECs) using conditioned
      medium (CM) from PGF2alpha-treated FPS cells from which ADAMTS1 was
      immunoneutralised and/or recombinant ADAMTS1. The role of endothelial ADAMTS1 in 
      endothelial cell proliferation was confirmed with RNA interference. The data in
      this study were analysed by T-test or ANOVA. RESULTS: ADAMTS1 mRNA and protein
      expression is elevated in endometrial adenocarcinoma tissues compared with normal
      proliferative phase endometrium and is localised to the glandular and vascular
      cells. Using FPS cells, we show that PGF2alpha-FP signalling upregulates ADAMTS1 
      expression via a calmodulin-NFAT-dependent pathway and this promotes epithelial
      cell invasion through ECM and inhibits endothelial cell proliferation.
      Furthermore, we show that CM from FPS cells regulates endothelial cell ADAMTS1
      expression in a rapid biphasic manner. Using RNA interference we show that
      endothelial cell ADAMTS1 also negatively regulates cellular proliferation.
      CONCLUSIONS: These data demonstrate elevated ADAMTS1 expression in endometrial
      adenocarcinoma. Furthermore we have highlighted a mechanism whereby FP receptor
      signalling regulates epithelial cell invasion and endothelial cell function via
      the PGF2alpha-FP receptor mediated induction of ADAMTS1.
FAU - Keightley, Margaret C
AU  - Keightley MC
AD  - Medical Research Council Human Reproductive Sciences Unit, The Queen's Medical
      Research Institute, The University of Edinburgh, Edinburgh, EH16 4TJ, UK.
FAU - Sales, Kurt J
AU  - Sales KJ
FAU - Jabbour, Henry N
AU  - Jabbour HN
LA  - eng
GR  - Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100914
PL  - England
TA  - BMC Cancer
JT  - BMC cancer
JID - 100967800
RN  - 0 (Calmodulin)
RN  - 0 (Culture Media, Conditioned)
RN  - 0 (NFATC Transcription Factors)
RN  - 0 (RNA, Messenger)
RN  - 0 (RNA, Small Interfering)
RN  - 0 (Receptors, Prostaglandin)
RN  - 0 (prostaglandin F2alpha receptor)
RN  - B7IN85G1HY (Dinoprost)
RN  - EC 3.4.24.- (ADAM Proteins)
RN  - EC 3.4.24.- (ADAMTS1 Protein)
RN  - EC 3.4.24.- (ADAMTS1 protein, human)
SB  - IM
MH  - ADAM Proteins/antagonists & inhibitors/genetics/*metabolism
MH  - ADAMTS1 Protein
MH  - Adenocarcinoma/metabolism/*pathology
MH  - Adult
MH  - Aged
MH  - Apoptosis
MH  - Blotting, Western
MH  - Calmodulin/genetics/metabolism
MH  - Cell Adhesion
MH  - *Cell Movement
MH  - Cell Proliferation
MH  - Cells, Cultured
MH  - Culture Media, Conditioned/pharmacology
MH  - Dinoprost/genetics/*metabolism
MH  - Endometrial Neoplasms/metabolism/*pathology
MH  - Endometrium/metabolism/*pathology
MH  - Endothelium, Vascular/cytology/metabolism
MH  - Female
MH  - Fluorescent Antibody Technique
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Middle Aged
MH  - NFATC Transcription Factors/genetics/metabolism
MH  - RNA, Messenger/genetics
MH  - RNA, Small Interfering/pharmacology
MH  - Receptors, Prostaglandin/genetics/*metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Signal Transduction
MH  - Umbilical Veins/cytology/metabolism
MH  - Young Adult
PMC - PMC2944181
EDAT- 2010/09/16 06:00
MHDA- 2011/02/04 06:00
CRDT- 2010/09/16 06:00
PHST- 2010/06/02 00:00 [received]
PHST- 2010/09/14 00:00 [accepted]
PHST- 2010/09/16 06:00 [entrez]
PHST- 2010/09/16 06:00 [pubmed]
PHST- 2011/02/04 06:00 [medline]
AID - 1471-2407-10-488 [pii]
AID - 10.1186/1471-2407-10-488 [doi]
PST - epublish
SO  - BMC Cancer. 2010 Sep 14;10:488. doi: 10.1186/1471-2407-10-488.


PMID- 20840462
OWN - NLM
STAT- MEDLINE
DCOM- 20101028
LR  - 20211020
IS  - 1532-5415 (Electronic)
IS  - 0002-8614 (Linking)
VI  - 58
IP  - 10
DP  - 2010 Oct
TI  - Sexual aggression between residents in nursing homes: literature synthesis of an 
      underrecognized problem.
PG  - 1970-9
LID - 10.1111/j.1532-5415.2010.03064.x [doi]
AB  - Evidence exists suggesting that most sexual aggression against older adults
      occurs in long-term care facilities. Fellow residents are the most common
      perpetrators, often demonstrating inappropriate hypersexual behavior caused by
      dementing illness. This resident-to-resident sexual aggression (RRSA) is defined 
      as sexual interactions between long-term care residents that, in a community
      setting, at least one of the recipients would be likely to construe as unwelcome 
      and that have high potential to cause physical or psychological distress in one
      or both of the involved residents. Although RRSA may be common, and physical and 
      psychological consequences for victims may be significant, this phenomenon has
      received little direct attention from researchers. This is a review of the
      existing literature and relevant related research examining elder sexual abuse
      and hypersexual behavior that describes the epidemiological features of this
      phenomenon, including risk factors for perpetrators and victims. The legitimate
      and recognized need for nursing home residents, even those with advanced
      dementing illness, to express themselves sexually makes preventing and managing
      sexual aggression in nursing homes more challenging. This review discusses the
      ethical dilemma this situation creates and the need to evaluate the capacity to
      consent to sexual activity of residents with dementing illness and to re-evaluate
      capacity as the diseases progress. Suggestions are offered for managing incidents
      of RRSA and for future research, including the importance of designing effective 
      interventions.
CI  - (c) 2010, Copyright the Authors. Journal compilation (c) 2010, The American
      Geriatrics Society.
FAU - Rosen, Tony
AU  - Rosen T
AD  - Emergency Medicine Residency Program, New York Presbyterian Hospital, New York,
      New York, USA.
FAU - Lachs, Mark S
AU  - Lachs MS
FAU - Pillemer, Karl
AU  - Pillemer K
LA  - eng
GR  - K24 AG022399/AG/NIA NIH HHS/United States
GR  - R01 AG014299/AG/NIA NIH HHS/United States
GR  - 1 P50 AG11711-01/AG/NIA NIH HHS/United States
GR  - R01 AG14299/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100914
PL  - United States
TA  - J Am Geriatr Soc
JT  - Journal of the American Geriatrics Society
JID - 7503062
SB  - IM
MH  - Aged
MH  - Aggression/*psychology
MH  - Dementia/*psychology
MH  - Humans
MH  - *Interpersonal Relations
MH  - *Nursing Homes
MH  - Sex Offenses/psychology/*statistics & numerical data
MH  - Sexual Behavior/*psychology
PMC - PMC3625650
MID - NIHMS234379
EDAT- 2010/09/16 06:00
MHDA- 2010/10/29 06:00
CRDT- 2010/09/16 06:00
PHST- 2010/09/16 06:00 [entrez]
PHST- 2010/09/16 06:00 [pubmed]
PHST- 2010/10/29 06:00 [medline]
AID - 10.1111/j.1532-5415.2010.03064.x [doi]
PST - ppublish
SO  - J Am Geriatr Soc. 2010 Oct;58(10):1970-9. doi: 10.1111/j.1532-5415.2010.03064.x. 
      Epub 2010 Sep 14.


PMID- 20840457
OWN - NLM
STAT- MEDLINE
DCOM- 20101028
LR  - 20101008
IS  - 1532-5415 (Electronic)
IS  - 0002-8614 (Linking)
VI  - 58
IP  - 10
DP  - 2010 Oct
TI  - Medical student perspectives on geriatrics and geriatric education.
PG  - 1994-9
LID - 10.1111/j.1532-5415.2010.03074.x [doi]
AB  - OBJECTIVE: To ascertain medical students' perspectives on geriatrics. DESIGN:
      Interpretative phenomenological analysis. SETTING: An allopathic, Liaison
      Committee on Medical Education-accredited, former Donald W. Reynolds Foundation
      grant recipient, U.S. medical school. PARTICIPANTS: Thirty fourth-year medical
      students who completed geriatric educational activities in all 4 years of medical
      school. MEASUREMENTS: Two researchers independently reviewed verbatim transcripts
      from five focus groups and identified themes using the constant comparative
      method. RESULTS: Seventeen themes that elaborate on students' perspectives on
      geriatrics were identified. Students reported not feeling appropriately engaged
      in geriatrics, despaired at the futility of care, were depressed by the decline
      and death of their patients, were frustrated by low reimbursement rates and low
      prestige despite fellowship training, were concerned about patients' unrealistic 
      expectations and opportunities for litigation, felt unsure how to handle ethical 
      dilemmas, and found communicating with older adults to be enjoyable but time
      consuming and challenging. They felt they had too much exposure to geriatrics in 
      medical school. CONCLUSION: Current attitude scales fail to capture some of the
      dimensions uncovered in this study, whereas students did not mention other
      dimensions commonly included in attitude scales. Regarding curriculum
      development, students may find an integrated preclinical geriatric curriculum to 
      be more relevant to their careers than a stand-alone curriculum. Clinical
      clerkships might be in a better position to emphasize the positive aspects of
      geriatrics and develop strategies to address students' negative attitudes.
CI  - (c) 2010, Copyright the Authors. Journal compilation (c) 2010, The American
      Geriatrics Society.
FAU - Bagri, Anita S
AU  - Bagri AS
AD  - Geriatric Research, Education, and Clinical Center, Bruce W. Carter Veterans
      Affairs Medical Center, Miami, Florida, USA. abmajor@bcm.tmc.edu
FAU - Tiberius, Richard
AU  - Tiberius R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20100914
PL  - United States
TA  - J Am Geriatr Soc
JT  - Journal of the American Geriatrics Society
JID - 7503062
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - *Career Choice
MH  - Education, Medical, Undergraduate/*methods
MH  - Educational Measurement
MH  - Geriatrics/*education
MH  - Humans
MH  - *Students, Medical
MH  - United States
EDAT- 2010/09/16 06:00
MHDA- 2010/10/29 06:00
CRDT- 2010/09/16 06:00
PHST- 2010/09/16 06:00 [entrez]
PHST- 2010/09/16 06:00 [pubmed]
PHST- 2010/10/29 06:00 [medline]
AID - 10.1111/j.1532-5415.2010.03074.x [doi]
PST - ppublish
SO  - J Am Geriatr Soc. 2010 Oct;58(10):1994-9. doi: 10.1111/j.1532-5415.2010.03074.x. 
      Epub 2010 Sep 14.


PMID- 20840369
OWN - NLM
STAT- MEDLINE
DCOM- 20110616
LR  - 20151119
IS  - 1365-2834 (Electronic)
IS  - 0966-0429 (Linking)
VI  - 18
IP  - 6
DP  - 2010 Sep
TI  - Perceptions of ethical practices in Hong Kong public hospitals: inter- and
      intra-professional similarities and differences.
PG  - 746-56
LID - 10.1111/j.1365-2834.2010.01102.x [doi]
AB  - AIM: To investigate similarities and differences in the perception of hospital
      ethical practices using different seniority of doctors, nurses and
      administrators, and between these healthcare professionals (HCPs). IMPORTANCE:
      Intra- and inter-professional similarities and differences had implications for
      HCPs' morale, hospital ethics climate and quality of patient care. METHOD: HCPs
      (n = 1.910) with different levels of seniority in 14 Hong Kong public hospitals
      were randomly surveyed between November 2004 and April 2005. RESULTS:
      Intra-professional differences in perception between senior and junior doctors or
      nurses were found in nine ethical themes including: quality of care, patient
      satisfaction, disagreements among HCPs and between HCPs and patient family,
      end-of-life care, professional incompetence and misconducts and communication.
      Inter-professional similarities in perception were also found among different
      HCPs in senior positions and as a group they differ from the perceptions of
      junior HCPs. CONCLUSIONS: Significant intra-professional and inter-professional
      polarizations of perception of ethical practices between senior and junior HCPs
      were found and they potentially undermine the trusting relationships between
      HCPs. IMPLICATIONS: As nursing managers were found to align with senior doctors
      and administrators, junior nurses might feel unsupported, isolated and
      frustrated, creating a nursing management challenge that must be faced.
CI  - (c) 2010 The Author. Journal compilation (c) 2010 Blackwell Publishing Ltd.
FAU - Hui, Edwin C
AU  - Hui EC
AD  - Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China.
      edwinhui@hkucc.hku.hk
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Nurs Manag
JT  - Journal of nursing management
JID - 9306050
MH  - Analysis of Variance
MH  - Clinical Competence
MH  - Confidence Intervals
MH  - *Ethics, Nursing
MH  - Health Care Surveys
MH  - Hong Kong
MH  - Hospitals, Public/*ethics/organization & administration
MH  - Humans
MH  - Interprofessional Relations
MH  - Job Satisfaction
MH  - *Organizational Culture
MH  - *Physician-Nurse Relations
MH  - Quality of Health Care
MH  - *Social Perception
MH  - Statistics as Topic
MH  - Surveys and Questionnaires
EDAT- 2010/09/16 06:00
MHDA- 2011/06/17 06:00
CRDT- 2010/09/16 06:00
PHST- 2010/09/16 06:00 [entrez]
PHST- 2010/09/16 06:00 [pubmed]
PHST- 2011/06/17 06:00 [medline]
AID - 10.1111/j.1365-2834.2010.01102.x [doi]
PST - ppublish
SO  - J Nurs Manag. 2010 Sep;18(6):746-56. doi: 10.1111/j.1365-2834.2010.01102.x.


PMID- 20840138
OWN - NLM
STAT- MEDLINE
DCOM- 20110204
LR  - 20100915
IS  - 1466-769X (Electronic)
IS  - 1466-7681 (Linking)
VI  - 11
IP  - 4
DP  - 2010 Oct
TI  - Destabilizing the 'equipoise' framework in clinical trials: prioritizing
      non-exploitation as an ethical framework in clinical research.
PG  - 271-9
LID - 10.1111/j.1466-769X.2010.00455.x [doi]
AB  - The framework of equipoise has been promulgated as an underlying requirement for 
      conducting ethical clinical research. Equipoise is the term used for a state of
      indifference about which treatment intervention or innovation will provide the
      most benefit and the least harm to recipients. Drawing on healthcare, research,
      and ethics literature, this paper analyses the implications of equipoise from the
      perspective of several proponents and critics. Specifically the historical
      evolution of the concept based on Fried and Freedman's arguments is traced. A
      critique of the concept, informed by contrasting perspectives, is offered. An
      alternative framework of non-exploitation as presented by Miller and Brody is
      argued to be superior in facilitating both the ultimate goals of research on
      human subjects and those of the healthcare professions'.
FAU - Schlichting, Douglas E
AU  - Schlichting DE
AD  - Connell School of Nursing, Boston College, Boston, MA, USA. schlichd@bc.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Nurs Philos
JT  - Nursing philosophy : an international journal for healthcare professionals
JID - 100897394
SB  - IM
MH  - Clinical Trials as Topic/*ethics
MH  - Decision Making
MH  - *Ethics, Research
MH  - Humans
MH  - *Nursing Research
MH  - *Philosophy, Nursing
MH  - Research Design
MH  - Therapeutic Human Experimentation/ethics
MH  - *Uncertainty
EDAT- 2010/09/16 06:00
MHDA- 2011/02/05 06:00
CRDT- 2010/09/16 06:00
PHST- 2010/09/16 06:00 [entrez]
PHST- 2010/09/16 06:00 [pubmed]
PHST- 2011/02/05 06:00 [medline]
AID - NUP455 [pii]
AID - 10.1111/j.1466-769X.2010.00455.x [doi]
PST - ppublish
SO  - Nurs Philos. 2010 Oct;11(4):271-9. doi: 10.1111/j.1466-769X.2010.00455.x.


PMID- 20840136
OWN - NLM
STAT- MEDLINE
DCOM- 20110204
LR  - 20100915
IS  - 1466-769X (Electronic)
IS  - 1466-7681 (Linking)
VI  - 11
IP  - 4
DP  - 2010 Oct
TI  - Faceless sex: glory holes and sexual assemblages.
PG  - 250-9
LID - 10.1111/j.1466-769X.2010.00452.x [doi]
AB  - According to our previous research, the use of glory holes in public venues such 
      as saunas and bathhouses is very popular. The popularity of glory holes is due in
      part to the anonymous sex that these architectural elements allow. This
      post-structuralist theoretical reflection seeks to understand the specific nature
      of anonymous public sex among bathhouse patrons, focusing on the links between
      desire-architecture-place-sexual practices. Drawing on interviews with glory hole
      users gathered during an ethnographic research project in bathhouses, this essay 
      goes beyond traditional public health discourse to offer an original perspective 
      on anonymous public sex. Utilizing the philosophy of Deleuze and Guattari's
      concepts of assemblages and machines, we re-theorize glory hole sex--what we call
      'faceless sex'--and rethink the ways that desire is imbricated with our
      understanding of architecture, place, and public. Finally, we reflect upon the
      particular ethical challenges that are posed by these particular sexual
      practices, and ask whether a post-structuralist ethic might be possible.
FAU - Holmes, Dave
AU  - Holmes D
AD  - School of Nursing, Faculty of Health Sciences, University of Ottawa, Ottawa, ON, 
      Canada. dholmes@uottawa.ca
FAU - O'Byrne, Patrick
AU  - O'Byrne P
FAU - Murray, Stuart J
AU  - Murray SJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Philos
JT  - Nursing philosophy : an international journal for healthcare professionals
JID - 100897394
SB  - IM
MH  - Anthropology, Cultural
MH  - Baths/psychology
MH  - Canada
MH  - Confidentiality
MH  - Erotica/psychology
MH  - Homosexuality, Male/*psychology
MH  - Humans
MH  - Interior Design and Furnishings
MH  - Interviews as Topic
MH  - Male
MH  - Privacy
MH  - *Public Facilities
MH  - Risk-Taking
MH  - Safe Sex/psychology
MH  - Sexual Behavior/*psychology
MH  - Sexually Transmitted Diseases/transmission
EDAT- 2010/09/16 06:00
MHDA- 2011/02/05 06:00
CRDT- 2010/09/16 06:00
PHST- 2010/09/16 06:00 [entrez]
PHST- 2010/09/16 06:00 [pubmed]
PHST- 2011/02/05 06:00 [medline]
AID - NUP452 [pii]
AID - 10.1111/j.1466-769X.2010.00452.x [doi]
PST - ppublish
SO  - Nurs Philos. 2010 Oct;11(4):250-9. doi: 10.1111/j.1466-769X.2010.00452.x.


PMID- 20839707
OWN - NLM
STAT- MEDLINE
DCOM- 20110204
LR  - 20191210
IS  - 1938-2367 (Electronic)
IS  - 0147-7447 (Linking)
VI  - 33
IP  - 9
DP  - 2010 Sep 7
TI  - Evaluation of high-strength orthopedic sutures: a head-to-head comparison.
PG  - 674
LID - 10.3928/01477447-20100722-08 [doi]
AB  - The goal of this study was to determine whether a difference in cycles to failure
      or mode of failure would be observed among specimens of 3 high-strength suture
      materials, and whether different suture configurations would affect knot
      security. Ten representative specimens of Ethibond (Ethicon, Inc, Somerville, New
      Jersey), FiberWire (Arthrex, Inc, Naples, Florida), MaxBraid (Biomet, Inc,
      Warsaw, Indiana), and Orthocord (DePuy Orthopaedics, Warsaw, Indiana) were tied
      in 6 different knot configurations commonly used in orthopedic procedures. Each
      specimen was cyclically loaded between 9 and 180 N at a rate of 1 Hz until the
      specimen failed or reached a maximum of 3500 cycles. Each suture material was
      subjected to tensile loading until failure at a rate of 1.25 mm/s. The 3 most
      secure knots all included the 3 reverse half-hitch on alternating posts (3-RHAP) 
      configuration. All specimens tied with these 3 knot types failed by suture
      rupture. All knots using the overhand with 3 of the same half-hitches on the same
      post (O-3SHSP) configuration failed by knot slippage regardless of suture
      material. When the 3 strongest knots were combined, FiberWire resisted a
      significantly greater number of fatigue cycles than Orthocord or MaxBraid. In the
      single load to failure tests, Orthocord, FiberWire, and MaxBraid all had
      significantly higher ultimate strength than Ethibond. Knots using the 3-RHAP
      configuration provide security superior to that of those without this
      configuration. All 3 high-strength sutures tested outperformed Ethibond in single
      load to failure testing, with FiberWire resisting the greatest number of cycles. 
      Postoperative strength and reliability of a soft tissue repair is inherently
      dependent on the properties of the suture materials used.
CI  - Copyright 2010, SLACK Incorporated.
FAU - Miller, Timothy
AU  - Miller T
AD  - Department of Orthopedics, The Ohio State University, Columbus, Ohio, USA.
FAU - Feinblatt, Jeff
AU  - Feinblatt J
FAU - Craw, John
AU  - Craw J
FAU - Litsky, Alan
AU  - Litsky A
FAU - Flanigan, David
AU  - Flanigan D
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
DEP - 20100907
PL  - United States
TA  - Orthopedics
JT  - Orthopedics
JID - 7806107
SB  - IM
MH  - Humans
MH  - *Materials Testing
MH  - *Orthopedic Procedures
MH  - Stress, Mechanical
MH  - *Suture Techniques
MH  - *Sutures
EDAT- 2010/09/16 06:00
MHDA- 2011/02/05 06:00
CRDT- 2010/09/16 06:00
PHST- 2010/09/16 06:00 [entrez]
PHST- 2010/09/16 06:00 [pubmed]
PHST- 2011/02/05 06:00 [medline]
AID - 10.3928/01477447-20100722-08 [doi]
PST - epublish
SO  - Orthopedics. 2010 Sep 7;33(9):674. doi: 10.3928/01477447-20100722-08.


PMID- 20839573
OWN - NLM
STAT- MEDLINE
DCOM- 20101005
LR  - 20100915
IS  - 0019-5847 (Print)
IS  - 0019-5847 (Linking)
VI  - 108
IP  - 1
DP  - 2010 Jan
TI  - Medical ethics vis-a-vis the medical profession.
PG  - 11
FAU - Haldar, Swaraj
AU  - Haldar S
LA  - eng
PT  - Editorial
PL  - India
TA  - J Indian Med Assoc
JT  - Journal of the Indian Medical Association
JID - 7505608
SB  - IM
MH  - *Ethics, Medical
MH  - Hippocratic Oath
MH  - Humans
MH  - Physicians/*ethics
EDAT- 2010/09/16 06:00
MHDA- 2010/10/06 06:00
CRDT- 2010/09/16 06:00
PHST- 2010/09/16 06:00 [entrez]
PHST- 2010/09/16 06:00 [pubmed]
PHST- 2010/10/06 06:00 [medline]
PST - ppublish
SO  - J Indian Med Assoc. 2010 Jan;108(1):11.


PMID- 20839559
OWN - NLM
STAT- MEDLINE
DCOM- 20101004
LR  - 20191111
IS  - 0048-7554 (Print)
IS  - 0048-7554 (Linking)
VI  - 25
IP  - 2
DP  - 2010 Jan-Mar
TI  - The intersection of sound principles of environmental epidemiologic research and 
      ethical guidelines and review: an example from Canada of an environmental
      case-control study.
PG  - 147-60
AB  - The present article challenges the ways in which ethical guidelines are
      implemented in reviewing the design and conduct of research involving human
      participants in observational studies in Canada. Fieldwork procedures should be
      designed in such a way as to be valid scientifically but also acceptable in terms
      of local ethical considerations, such as confidentiality of participant's
      identity and information, and other social norms. To set the stage, I present
      briefly essential information regarding the valid design and conduct of
      observational epidemiologic studies. As an example of the difficulties
      encountered in implementing these procedures, I present my experience in gaining 
      ethical approval for a population-based, case-control study of environmental
      causes of postmenopausal breast cancer.
FAU - Goldberg, Mark S
AU  - Goldberg MS
AD  - Department of Medicine, McGill University, Montreal, Quebec, Canada.
      mark.goldberg@mcgill.ca
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Rev Environ Health
JT  - Reviews on environmental health
JID - 0425754
SB  - IM
MH  - Breast Neoplasms/epidemiology/etiology
MH  - Canada/epidemiology
MH  - *Case-Control Studies
MH  - Confidentiality
MH  - *Environment
MH  - *Epidemiologic Methods
MH  - Ethics Committees, Research/organization & administration
MH  - *Ethics, Research
MH  - Female
MH  - Humans
MH  - Patient Selection/ethics
MH  - Postmenopause
MH  - *Research Design
MH  - Social Environment
EDAT- 2010/09/16 06:00
MHDA- 2010/10/05 06:00
CRDT- 2010/09/16 06:00
PHST- 2010/09/16 06:00 [entrez]
PHST- 2010/09/16 06:00 [pubmed]
PHST- 2010/10/05 06:00 [medline]
AID - 10.1515/reveh.2010.25.2.147 [doi]
PST - ppublish
SO  - Rev Environ Health. 2010 Jan-Mar;25(2):147-60. doi: 10.1515/reveh.2010.25.2.147.


PMID- 20839545
OWN - NLM
STAT- MEDLINE
DCOM- 20101028
LR  - 20191111
IS  - 0102-6933 (Print)
IS  - 0102-6933 (Linking)
VI  - 31
IP  - 1
DP  - 2010 Mar
TI  - [Profile of caretakers of elderly people with cognitive alterations in different 
      contexts of social vulnerability].
PG  - 115-22
AB  - The purpose of this study is to characterize caretakers of elderly people with
      cognitive disorders, users of Family Health Units (FHU), that live in different
      contexts of social vulnerability. Household interviews were conducted (N = 72)
      with the use of an instrument previously designed, containing socioeconomic and
      demographic characterization data. All ethical cares have been observed. The
      results show that caretakers of elderly people that live in contexts of high
      social vulnerability are primarily adult, married women, with incomplete
      elementary school education, who work at home. These caretakers live with the
      elderly person they are in charge of develop a dose relationship with them and do
      not receive help from professionals. Similar data were found in contexts of low
      social vulnerability, except that in those cases the support of a formal
      caretaker is available. The study of the profile of caretakers of elderly people 
      with cognitive alterations living in different contexts of social vulnerability
      can provide FHU with subsidies so that they can formulate more specific care
      strategies to caretakers.
FAU - dos Santos, Ariene Angelini
AU  - dos Santos AA
AD  - Enfermagem pela UFSCar, Sao Carlos, Sao Paulo, Brasil.
      arieneangelini@yahoo.com.br
FAU - Pavarini, Sofia Cristina Iost
AU  - Pavarini SC
LA  - por
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
TT  - Perfil dos cuidadores de idosos com alteracoes cognitivas em diferentes contextos
      de vulnerabilidade social.
PL  - Brazil
TA  - Rev Gaucha Enferm
JT  - Revista gaucha de enfermagem
JID - 8504882
MH  - Adult
MH  - Aged
MH  - *Caregivers
MH  - *Cognition Disorders
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Socioeconomic Factors
MH  - Vulnerable Populations
EDAT- 2010/09/16 06:00
MHDA- 2010/10/29 06:00
CRDT- 2010/09/16 06:00
PHST- 2010/09/16 06:00 [entrez]
PHST- 2010/09/16 06:00 [pubmed]
PHST- 2010/10/29 06:00 [medline]
AID - 10.1590/s1983-14472010000100016 [doi]
PST - ppublish
SO  - Rev Gaucha Enferm. 2010 Mar;31(1):115-22. doi: 10.1590/s1983-14472010000100016.


PMID- 20839535
OWN - NLM
STAT- MEDLINE
DCOM- 20101028
LR  - 20191111
IS  - 0102-6933 (Print)
IS  - 0102-6933 (Linking)
VI  - 31
IP  - 1
DP  - 2010 Mar
TI  - [Students' practice in the construction of knowledge about the phenomenon of drug
      abuse].
PG  - 41-7
AB  - This is a qualitative descriptive research, carried out with nursing
      undergraduates from Rio de Janeiro State University, Brazil. The purpose is to
      discuss students' experiences and their social practice in assisting drugs uses. 
      Data were collected from December 2008 to January, 2009, with the use of focal
      groups composed by 19 undergraduates from the last three semesters of the course.
      The project was approved by the Ethics Research Commission. All participants
      signed the Informed Consent. The results evidenced students' difficulty in facing
      reality, due to the contrast between theory and practice. Such difficulty came
      out as a consequence of an inapropriate educational approach. We concluded that
      the academic institutions should optimize the use of teaching process.
      Professional formation related to the phenomenon of drug abuse is considered
      essential as it becomes more and more frequent in nurses' daily routines.
FAU - dos Santos, Vanessa Oliveira Guimaraes
AU  - dos Santos VO
AD  - Programa de Pos-Graduacao em Enfermagem da UERJ, Lider da Equipe de Enfermagem na
      Casa de Saude Sao Jose, Rio de Janeiro, Brasil.
FAU - Vargens, Octavio Muniz da Costa
AU  - Vargens OM
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - A pratica discente na construcao do conhecimento sobre o fenomeno das drogas.
PL  - Brazil
TA  - Rev Gaucha Enferm
JT  - Revista gaucha de enfermagem
JID - 8504882
MH  - *Education, Nursing
MH  - Humans
MH  - *Students, Nursing
MH  - *Substance-Related Disorders
EDAT- 2010/09/16 06:00
MHDA- 2010/10/29 06:00
CRDT- 2010/09/16 06:00
PHST- 2010/09/16 06:00 [entrez]
PHST- 2010/09/16 06:00 [pubmed]
PHST- 2010/10/29 06:00 [medline]
AID - 10.1590/s1983-14472010000100006 [doi]
PST - ppublish
SO  - Rev Gaucha Enferm. 2010 Mar;31(1):41-7. doi: 10.1590/s1983-14472010000100006.


PMID- 20839534
OWN - NLM
STAT- MEDLINE
DCOM- 20101028
LR  - 20191210
IS  - 0102-6933 (Print)
IS  - 0102-6933 (Linking)
VI  - 31
IP  - 1
DP  - 2010 Mar
TI  - [Nursing outcomes classification applicability on patients with self-care deficit
      bathing/hygiene].
PG  - 33-40
AB  - The purpose of this research is to explore the Nursing Outcomes Classification
      (NOC) applicability on hospitalized orthopedic patients diagnosed with Self-care 
      Deficit: bathing/hygiene. This is a quantitative, descriptive study developed in 
      a university hospital with patients submitted to total hip replacement in 2008.
      The data collection instrument was composed of 24 NOC Self-care outcome
      indicator: Self-care: Activities of Daily Living; Self-care: Bathing; Self-care: 
      Hygiene; Self-care: Oral Hygiene; and a Likert scale in which 1 = dependent 2 =
      does not participate; 3 = requires an assistant; 4 = independent but requires an 
      assistant mechanism; 5 = completely independent. 25 patients bathing on first and
      third post-operative day were observed. Ethical aspects were respected. In 21
      cases there was significant statistical variation between average scores from
      first to second bath. NOC classification scales presented internal consistency,
      proving their reliability to measure the patient evolution during nursing care
      implementation.
FAU - Almeida, Miriam de Abreu
AU  - Almeida Mde A
AD  - Escola de Enfermagem da Universidade Federal do Rio Grande do Sul (UFRGS), Porto 
      Alegre, Rio Grande do Sul, Brasil. miriam.abreu@terra.com.br
FAU - Seganfredo, Deborah Hein
AU  - Seganfredo DH
FAU - do Canto, Debora Francisco
AU  - do Canto DF
FAU - Barreto, Luciana Nabinger Menna
AU  - Barreto LN
LA  - por
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
TT  - Aplicabilidade da classificacao dos resultados de enfermagem em pacientes com
      deficit no autocuidado: banho/higiene.
PL  - Brazil
TA  - Rev Gaucha Enferm
JT  - Revista gaucha de enfermagem
JID - 8504882
MH  - *Activities of Daily Living
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Nursing Process
MH  - *Orthopedic Nursing
MH  - Outcome Assessment, Health Care
EDAT- 2010/09/16 06:00
MHDA- 2010/10/29 06:00
CRDT- 2010/09/16 06:00
PHST- 2010/09/16 06:00 [entrez]
PHST- 2010/09/16 06:00 [pubmed]
PHST- 2010/10/29 06:00 [medline]
AID - 10.1590/s1983-14472010000100005 [doi]
PST - ppublish
SO  - Rev Gaucha Enferm. 2010 Mar;31(1):33-40. doi: 10.1590/s1983-14472010000100005.


PMID- 20839480
OWN - NLM
STAT- MEDLINE
DCOM- 20101021
LR  - 20191111
IS  - 1521-0987 (Print)
IS  - 1938-9019 (Linking)
VI  - 11
IP  - 3
DP  - 2010
TI  - The relational nature of case manager resource allocation decision making: an
      illustrated case.
PG  - 151-6
AB  - We used ethnographic methods in the tradition of Spradley (1979) and constant
      comparative analysis to explore case manager resource allocation decision making.
      We interviewed; observed and shadowed 11 case managers within a children's home
      care program in a regional health authority in western Canada as they went about 
      their daily work over a 5-month period. Our findings provide knowledge about the 
      little-understood set of processes at the micro level of resource allocation.
      Although the case manager considers many factors, reported elsewhere (Fraser,
      Estabrooks, Allen, & Strang, 2009), they balance and weigh these factors within a
      relational context. The purpose of this article is to use Jenna's story as a case
      example to illustrate how the case manager balances and weighs the factors that
      influence their resource allocation decisions within this context. Jenna's story 
      demonstrates the complex and multidimensional processes that are embedded in the 
      relational nature of resource allocation decisions. We discuss home care case
      manager resource allocation decisions as viewed through the lens of relational
      ethics.
FAU - Fraser, Kimberly D
AU  - Fraser KD
AD  - Faculty of Nursing, University of Alberta, Edmonton, Canada.
      kimberly.fraser@ualberta.ca
FAU - Estabrooks, Carole
AU  - Estabrooks C
FAU - Allen, Marion
AU  - Allen M
FAU - Strang, Vicki
AU  - Strang V
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Care Manag J
JT  - Care management journals : Journal of case management ; The journal of long term 
      home health care
JID - 100888264
SB  - IM
MH  - Case Management
MH  - Child
MH  - *Child Health Services
MH  - *Decision Making
MH  - Female
MH  - *Home Care Services
MH  - Humans
MH  - Paraplegia/*rehabilitation
MH  - Resource Allocation/*methods
EDAT- 2010/09/16 06:00
MHDA- 2010/10/22 06:00
CRDT- 2010/09/16 06:00
PHST- 2010/09/16 06:00 [entrez]
PHST- 2010/09/16 06:00 [pubmed]
PHST- 2010/10/22 06:00 [medline]
AID - 10.1891/1521-0987.11.3.151 [doi]
PST - ppublish
SO  - Care Manag J. 2010;11(3):151-6. doi: 10.1891/1521-0987.11.3.151.


PMID- 20839117
OWN - NLM
STAT- MEDLINE
DCOM- 20110125
LR  - 20100914
IS  - 1938-3800 (Electronic)
IS  - 0742-3225 (Linking)
VI  - 42
IP  - 8
DP  - 2010 Sep
TI  - Mass critical care ethics: black and white, or grey?
PG  - 587-8
FAU - Metz, John P
AU  - Metz JP
AD  - UMDNJ-Robert Wood Johnson Medical School, USA. jmetz@solarishs.org
FAU - Winter, Robin O
AU  - Winter RO
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Fam Med
JT  - Family medicine
JID - 8306464
SB  - IM
MH  - Critical Care/*ethics/methods
MH  - Curriculum
MH  - Education, Medical, Graduate/*ethics
MH  - *Ethics, Medical
MH  - Family Practice/*ethics
MH  - Humans
MH  - Internship and Residency/*ethics
MH  - Triage
MH  - United States
EDAT- 2010/09/15 06:00
MHDA- 2011/01/28 06:00
CRDT- 2010/09/15 06:00
PHST- 2010/09/15 06:00 [entrez]
PHST- 2010/09/15 06:00 [pubmed]
PHST- 2011/01/28 06:00 [medline]
PST - ppublish
SO  - Fam Med. 2010 Sep;42(8):587-8.


PMID- 20838989
OWN - NLM
STAT- MEDLINE
DCOM- 20110310
LR  - 20211020
IS  - 1433-3023 (Electronic)
IS  - 0937-3462 (Linking)
VI  - 21
IP  - 12
DP  - 2010 Dec
TI  - Biomechanical properties of prolapsed or non-prolapsed vaginal tissue: impact on 
      genital prolapse surgery.
PG  - 1535-8
LID - 10.1007/s00192-010-1208-z [doi]
AB  - INTRODUCTION AND HYPOTHESIS: Our aim is to characterize prolapsed and
      non-prolapsed vaginal tissue, and thus offer a better understanding of the
      genital prolapse physiopathology and an improvement of surgical treatments.
      METHODS: Vaginal tissue was collected in 30 patients with prolapse (POP) and ten 
      fresh cadavers without prolapse (nPOP) with a favorable advice of Ethics
      Committee. Uniaxial tension tests were performed. Statistical comparisons of
      rigidity under moderate deformation and under large deformation have been
      performed RESULTS: POP is significantly stiffer than nPOP tissue, both on
      anterior and posterior walls. A significant difference between POP and nPOP
      tissues was highlighted when anterior or posterior vaginal walls were
      respectively compared. CONCLUSIONS: These results might explain the higher rate
      of relapse when repair is autologous, using already defective and more rigid
      vaginal tissue. This study suggests that it might be interesting to adapt the
      characteristics of prosthetic implants to the vaginal face concerned by the
      prolapsus.
FAU - Jean-Charles, Clay
AU  - Jean-Charles C
AD  - Clinique de Chirurgie Gynecologique, Hopital Jeanne de Flandre, CHRU de Lille,
      Lille, France.
FAU - Rubod, Chrystele
AU  - Rubod C
FAU - Brieu, Mathias
AU  - Brieu M
FAU - Boukerrou, Malik
AU  - Boukerrou M
FAU - Fasel, Jean
AU  - Fasel J
FAU - Cosson, Michel
AU  - Cosson M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100914
PL  - England
TA  - Int Urogynecol J
JT  - International urogynecology journal
JID - 101567041
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomechanical Phenomena
MH  - Cadaver
MH  - Female
MH  - *Gynecologic Surgical Procedures/methods
MH  - Humans
MH  - Middle Aged
MH  - Uterine Prolapse/pathology/*physiopathology/surgery
MH  - Vagina/pathology/*physiopathology
EDAT- 2010/09/15 06:00
MHDA- 2011/03/11 06:00
CRDT- 2010/09/15 06:00
PHST- 2009/11/13 00:00 [received]
PHST- 2010/06/08 00:00 [accepted]
PHST- 2010/09/15 06:00 [entrez]
PHST- 2010/09/15 06:00 [pubmed]
PHST- 2011/03/11 06:00 [medline]
AID - 10.1007/s00192-010-1208-z [doi]
PST - ppublish
SO  - Int Urogynecol J. 2010 Dec;21(12):1535-8. doi: 10.1007/s00192-010-1208-z. Epub
      2010 Sep 14.


PMID- 20838402
OWN - NLM
STAT- MEDLINE
DCOM- 20120109
LR  - 20220318
IS  - 1476-5624 (Electronic)
IS  - 1362-4393 (Linking)
VI  - 49
IP  - 2
DP  - 2011 Feb
TI  - Ethics, health care and spinal cord injury: research, practice and finance.
PG  - 162-74
LID - 10.1038/sc.2010.106 [doi]
AB  - Dating back to ancient times, mankind has been absorbed with 'doing the right
      thing', that is, behaving in ways approved by the society and the culture during 
      the era in which they lived. This has been and still is especially true for the
      medical and related health-care professions. Laws and professional codes have
      evolved over the years that provide guidelines as to how physicians should treat 
      patients, beginning with the one authored by Hippocrates. Only more recently,
      however, have laws and codes been created to cover health-care research and the
      advances in health-care practice that have been brought to light by that
      research. Although these discoveries have clearly impacted the quality of life
      and duration of life for people with spinal cord injury and other maladies, they 
      have also raised questions that go beyond the science. Questions such as when,
      why, how and for how long should such treatments be applied often relate more to 
      what a society and its culture will condone and the answers can differ and have
      differed among societies depending on the prevailing ethics and morals. Modern
      codes and laws have been created so that the trust people have traditionally
      placed in their healers will not be violated or misused as happened during wars
      past, especially in Nazi Germany. This paper will trace the evolution of the
      rules that medical researchers, practitioners and payers for treatment must now
      follow and explain why guiding all their efforts that honesty must prevail.
FAU - Donovan, W H
AU  - Donovan WH
AD  - Physical Medicine and Rehabilitation, University of Texas Health Science
      Center-Houston, Houston, TX 77030, USA. William.Donovan@memorialhermann.org
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20100914
PL  - England
TA  - Spinal Cord
JT  - Spinal cord
JID - 9609749
SB  - IM
MH  - Codes of Ethics/legislation & jurisprudence/*trends
MH  - *Ethics, Medical
MH  - Humans
MH  - Physician-Patient Relations/*ethics
MH  - Practice Guidelines as Topic/standards
MH  - Spinal Cord Injuries/*economics/*therapy
EDAT- 2010/09/15 06:00
MHDA- 2012/01/10 06:00
CRDT- 2010/09/15 06:00
PHST- 2010/09/15 06:00 [entrez]
PHST- 2010/09/15 06:00 [pubmed]
PHST- 2012/01/10 06:00 [medline]
AID - sc2010106 [pii]
AID - 10.1038/sc.2010.106 [doi]
PST - ppublish
SO  - Spinal Cord. 2011 Feb;49(2):162-74. doi: 10.1038/sc.2010.106. Epub 2010 Sep 14.


PMID- 20837595
OWN - NLM
STAT- MEDLINE
DCOM- 20101027
LR  - 20101005
IS  - 1098-4275 (Electronic)
IS  - 0031-4005 (Linking)
VI  - 126
IP  - 4
DP  - 2010 Oct
TI  - Ethics rounds. Symbolic resuscitation, medical futility, and parental rights.
PG  - 769-72
LID - 10.1542/peds.2010-1379 [doi]
FAU - Frader, Joel
AU  - Frader J
AD  - Department of Pediatrics Medical Humanities/Bioethics, Feinberg School of
      Medicine, Northwestern University, and Palliative Care, Children's Memorial
      Hospital, Chicago, IL, USA.
FAU - Kodish, Eric
AU  - Kodish E
FAU - Lantos, John D
AU  - Lantos JD
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20100913
PL  - United States
TA  - Pediatrics
JT  - Pediatrics
JID - 0376422
SB  - IM
MH  - Child, Preschool
MH  - *Ethics
MH  - *Family Conflict
MH  - Female
MH  - Humans
MH  - Medical Futility/ethics
MH  - Palliative Care
MH  - *Parental Consent
MH  - Resuscitation Orders/*ethics
EDAT- 2010/09/15 06:00
MHDA- 2010/10/28 06:00
CRDT- 2010/09/15 06:00
PHST- 2010/09/15 06:00 [entrez]
PHST- 2010/09/15 06:00 [pubmed]
PHST- 2010/10/28 06:00 [medline]
AID - peds.2010-1379 [pii]
AID - 10.1542/peds.2010-1379 [doi]
PST - ppublish
SO  - Pediatrics. 2010 Oct;126(4):769-72. doi: 10.1542/peds.2010-1379. Epub 2010 Sep
      13.


PMID- 20837587
OWN - NLM
STAT- MEDLINE
DCOM- 20101027
LR  - 20101005
IS  - 1098-4275 (Electronic)
IS  - 0031-4005 (Linking)
VI  - 126
IP  - 4
DP  - 2010 Oct
TI  - Policy statement--recommendation for mandatory influenza immunization of all
      health care personnel.
PG  - 809-15
LID - 10.1542/peds.2010-2376 [doi]
AB  - The purpose of this statement is to recommend implementation of a mandatory
      influenza immunization policy for all health care personnel. Immunization of
      health care personnel is a critically important step to substantially reduce
      health care-associated influenza infections. Despite the efforts of many
      organizations to improve influenza immunization rates with the use of voluntary
      campaigns, influenza coverage among health care personnel remains unacceptably
      low. Mandatory influenza immunization for all health care personnel is ethically 
      justified, necessary, and long overdue to ensure patient safety.
FAU - Bernstein, Henry H
AU  - Bernstein HH
FAU - Starke, Jeffrey R
AU  - Starke JR
CN  - American Academy of Pediatrics. Committee on Infectious Diseases
LA  - eng
PT  - Journal Article
PT  - Practice Guideline
DEP - 20100913
PL  - United States
TA  - Pediatrics
JT  - Pediatrics
JID - 0376422
SB  - IM
MH  - Cross Infection/prevention & control
MH  - *Health Personnel
MH  - Humans
MH  - *Immunization
MH  - Infectious Disease Transmission, Professional-to-Patient/prevention & control
MH  - Influenza, Human/*prevention & control/transmission
MH  - *Mandatory Programs/organization & administration/standards
IR  - Brady MT
FIR - Brady, Michael T
IR  - Bernstein HH
FIR - Bernstein, Henry H
IR  - Byington CL
FIR - Byington, Carrie L
IR  - Edwards K
FIR - Edwards, Kathryn
IR  - Fisher MC
FIR - Fisher, Margaret C
IR  - Glode MP
FIR - Glode, Mary P
IR  - Jackson MA
FIR - Jackson, Mary Anne
IR  - Keyserling HL
FIR - Keyserling, Harry L
IR  - Kimberlin DW
FIR - Kimberlin, David W
IR  - Maldonado Y
FIR - Maldonado, Yvonne
IR  - Orenstein WA
FIR - Orenstein, Walter A
IR  - Schutze GE
FIR - Schutze, Gordon E
IR  - Willoughby RE
FIR - Willoughby, Rodney E
EDAT- 2010/09/15 06:00
MHDA- 2010/10/28 06:00
CRDT- 2010/09/15 06:00
PHST- 2010/09/15 06:00 [entrez]
PHST- 2010/09/15 06:00 [pubmed]
PHST- 2010/10/28 06:00 [medline]
AID - peds.2010-2376 [pii]
AID - 10.1542/peds.2010-2376 [doi]
PST - ppublish
SO  - Pediatrics. 2010 Oct;126(4):809-15. doi: 10.1542/peds.2010-2376. Epub 2010 Sep
      13.


PMID- 20837057
OWN - NLM
STAT- MEDLINE
DCOM- 20111229
LR  - 20181201
IS  - 1872-6321 (Electronic)
IS  - 0165-0173 (Linking)
VI  - 66
IP  - 1-2
DP  - 2011 Jan 7
TI  - Giuseppe Moruzzi: a tribute to a "formidable" scientist and a "formidable" man.
PG  - 256-69
LID - 10.1016/j.brainresrev.2010.09.004 [doi]
AB  - Giuseppe Moruzzi was born one century ago; he was an outstanding Italian
      neurophysiologist, who was particularly famous for his contributions to the study
      of the mechanisms underlying the control of the sleep-waking cycle in mammals. In
      1990, Rita Levi-Montalcini, Moruzzi's great friend and admirer, used the occasion
      of an invitation by the University of Parma, where Moruzzi graduated in medicine 
      in 1933, to celebrate Moruzzi's scientific achievements. She wished to pay a
      tribute to Moruzzi's human and ethical qualities by portraying him as a "perfect 
      model" for the young generation wishing to pursue scientific research. The
      transcription of "Rita's" tribute to Moruzzi links two of the greatest figures of
      Italian neuroscience and also provides a lively account of how the personal
      histories of two promising young scientists intertwined with the great and tragic
      events of world history in the past century.
CI  - Copyright (c) 2010 Elsevier B.V. All rights reserved.
FAU - Levi-Montalcini, Rita
AU  - Levi-Montalcini R
AD  - European Brain Research Institute, Rome, Italy.
FAU - Piccolino, Marco
AU  - Piccolino M
FAU - Wade, Nicholas J
AU  - Wade NJ
LA  - eng
PT  - Biography
PT  - Historical Article
PT  - Lecture
PT  - Portrait
DEP - 20100915
PL  - Netherlands
TA  - Brain Res Rev
JT  - Brain research reviews
JID - 101300366
SB  - IM
MH  - Academic Medical Centers/history
MH  - History, 20th Century
MH  - Italy
MH  - National Socialism/history
MH  - Neurophysiology/*history
MH  - Neurosciences/*history
MH  - United States
PS  - Moruzzi G
FPS - Moruzzi, Giuseppe
EDAT- 2010/09/15 06:00
MHDA- 2011/12/30 06:00
CRDT- 2010/09/15 06:00
PHST- 2010/05/01 00:00 [received]
PHST- 2010/08/30 00:00 [revised]
PHST- 2010/09/02 00:00 [accepted]
PHST- 2010/09/15 06:00 [entrez]
PHST- 2010/09/15 06:00 [pubmed]
PHST- 2011/12/30 06:00 [medline]
AID - S0165-0173(10)00103-7 [pii]
AID - 10.1016/j.brainresrev.2010.09.004 [doi]
PST - ppublish
SO  - Brain Res Rev. 2011 Jan 7;66(1-2):256-69. doi: 10.1016/j.brainresrev.2010.09.004.
      Epub 2010 Sep 15.


PMID- 20836861
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1472-684X (Electronic)
IS  - 1472-684X (Linking)
VI  - 9
DP  - 2010 Sep 13
TI  - European Association for Palliative Care (EAPC) framework for palliative
      sedation: an ethical discussion.
PG  - 20
LID - 10.1186/1472-684X-9-20 [doi]
AB  - BACKGROUND: The aim of this paper is to critically discuss some of the ethically 
      controversial issues regarding continuous deep palliative sedation at the end of 
      life that are addressed in the EAPC recommended framework for the use of sedation
      in palliative care. DISCUSSION: We argue that the EAPC framework would have
      benefited from taking a clearer stand on the ethically controversial issues
      regarding intolerable suffering and refractory symptoms and regarding the
      relation between continuous deep palliative sedation at the end of life and
      euthanasia. It is unclear what constitutes refractory symptoms and what the
      relationship is between refractory symptoms and intolerable suffering, which in
      turn makes it difficult to determine what are necessary and sufficient criteria
      for palliative sedation at the end of life, and why. As regards the difference
      between palliative sedation at the end of life and so-called slow euthanasia, the
      rationale behind stressing the difference is insufficiently demonstrated, e.g.
      due to an overlooked ambiguity in the concept of intention. It is therefore
      unclear when palliative sedation at the end of life amounts to abuse and why.
      CONCLUSIONS: The EAPC framework would have benefited from taking a clearer stand 
      on some ethically controversial issues regarding intolerable suffering and
      refractory symptoms and regarding the relation between continuous deep palliative
      sedation at the end of life and euthanasia. In this text, we identify and discuss
      these issues in the hope that an ensuing discussion will clarify the EAPC's
      standpoint.
FAU - Juth, Niklas
AU  - Juth N
AD  - Karolinska institutet, Stockholm Centre for Healthcare Ethics (CHE), LIME,
      Berzelius vag 3, plan 4, 171 77 Stockholm, Sweden. niklas.juth@ki.se.
FAU - Lindblad, Anna
AU  - Lindblad A
FAU - Lynoe, Niels
AU  - Lynoe N
FAU - Sjostrand, Manne
AU  - Sjostrand M
FAU - Helgesson, Gert
AU  - Helgesson G
LA  - eng
PT  - Journal Article
DEP - 20100913
PL  - England
TA  - BMC Palliat Care
JT  - BMC palliative care
JID - 101088685
PMC - PMC2945325
EDAT- 2010/09/15 06:00
MHDA- 2010/09/15 06:01
CRDT- 2010/09/15 06:00
PHST- 2010/03/30 00:00 [received]
PHST- 2010/09/13 00:00 [accepted]
PHST- 2010/09/15 06:00 [entrez]
PHST- 2010/09/15 06:00 [pubmed]
PHST- 2010/09/15 06:01 [medline]
AID - 1472-684X-9-20 [pii]
AID - 10.1186/1472-684X-9-20 [doi]
PST - epublish
SO  - BMC Palliat Care. 2010 Sep 13;9:20. doi: 10.1186/1472-684X-9-20.


PMID- 20836796
OWN - NLM
STAT- MEDLINE
DCOM- 20110112
LR  - 20211020
IS  - 1750-2659 (Electronic)
IS  - 1750-2640 (Linking)
VI  - 4
IP  - 4
DP  - 2010 Jul
TI  - Pre-pandemic planning survey of healthcare workers at a tertiary care children's 
      hospital: ethical and workforce issues.
PG  - 213-22
LID - 10.1111/j.1750-2659.2010.00145.x [doi]
AB  - BACKGROUND: Prior to the development of written policies and procedures for
      pandemic influenza, worker perceptions of ethical and workforce issues must be
      identified. OBJECTIVE: To determine the relationship between healthcare worker
      (HCW) reporting willingness to work during a pandemic and perception of job
      importance, belief that one will be asked to work, and sense of professionalism
      and to assess HCW's opinions regarding specific policy issues as well as barriers
      and motivators to work during a pandemic. METHODS: A survey was conducted in HCWs
      at The Children's Hospital in Denver, Colorado, from February to June 2007.
      Characteristics of workers reporting willingness to work during a pandemic were
      compared with those who were unwilling or unsure. Importance of barriers and
      motivators was compared by gender and willingness to work. RESULTS: Sixty percent
      of respondents reported willingness to work (overall response rate of 31%).
      Belief one will be asked to work (OR 4.6, P < 0.0001) and having a high level of 
      professionalism (OR 8.6, P < 0.0001) were associated with reporting willingness
      to work. Hospital infrastructure support staffs were less likely to report
      willingness to work during a pandemic than clinical healthcare professionals (OR 
      0.39, P < 0.001). Concern for personal safety, concern for safety of family,
      family's concern for safety, and childcare issues were all important barriers to 
      coming to work. CONCLUSIONS: Educational programs should focus on professional
      responsibility and the importance of staying home when ill. Targeted programs
      toward hospital infrastructure support and patient and family support staff
      stressing the essential nature of these jobs may improve willingness to work.
FAU - Cowden, Jessica
AU  - Cowden J
AD  - Department of Pediatrics, University of Colorado, Denver, CO, USA.
      Jessica.cowden@keesler.af.mil
FAU - Crane, Lori
AU  - Crane L
FAU - Lezotte, Dennis
AU  - Lezotte D
FAU - Glover, Jacqueline
AU  - Glover J
FAU - Nyquist, Ann-Christine
AU  - Nyquist AC
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - Influenza Other Respir Viruses
JT  - Influenza and other respiratory viruses
JID - 101304007
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Attitude of Health Personnel
MH  - Colorado
MH  - Delivery of Health Care/ethics
MH  - Disaster Planning
MH  - Ethics, Clinical
MH  - Ethics, Medical
MH  - Female
MH  - *Health Care Surveys
MH  - Health Personnel/*ethics/*psychology
MH  - Health Planning
MH  - *Hospitals, Pediatric
MH  - Humans
MH  - Influenza, Human/*prevention & control/therapy
MH  - Male
MH  - Middle Aged
MH  - Pandemics/*prevention & control
MH  - Surveys and Questionnaires
MH  - Workload
MH  - Young Adult
PMC - PMC4940933
EDAT- 2010/09/15 06:00
MHDA- 2011/01/13 06:00
CRDT- 2010/09/15 06:00
PHST- 2010/09/15 06:00 [entrez]
PHST- 2010/09/15 06:00 [pubmed]
PHST- 2011/01/13 06:00 [medline]
AID - IRV145 [pii]
AID - 10.1111/j.1750-2659.2010.00145.x [doi]
PST - ppublish
SO  - Influenza Other Respir Viruses. 2010 Jul;4(4):213-22. doi:
      10.1111/j.1750-2659.2010.00145.x.


PMID- 20836781
OWN - NLM
STAT- MEDLINE
DCOM- 20110211
LR  - 20110509
IS  - 1553-2712 (Electronic)
IS  - 1069-6563 (Linking)
VI  - 17
IP  - 9
DP  - 2010 Sep
TI  - Procedural versus practical ethics.
PG  - 989-90
LID - 10.1111/j.1553-2712.2010.00863.x [doi]
FAU - Biros, Michelle H
AU  - Biros MH
FAU - Hauswald, Mark
AU  - Hauswald M
FAU - Baren, Jill
AU  - Baren J
LA  - eng
PT  - Comment
PT  - Editorial
PL  - United States
TA  - Acad Emerg Med
JT  - Academic emergency medicine : official journal of the Society for Academic
      Emergency Medicine
JID - 9418450
SB  - IM
CON - Acad Emerg Med. 2010 Sep;17(9):1012-5. PMID: 20836786
MH  - Cardiopulmonary Resuscitation
MH  - Ethical Analysis
MH  - *Ethics Committees, Research
MH  - *Ethics, Research
MH  - Humans
MH  - Periodicals as Topic/ethics
MH  - Publication Bias
MH  - Switzerland
MH  - United States
EDAT- 2010/09/15 06:00
MHDA- 2011/02/12 06:00
CRDT- 2010/09/15 06:00
PHST- 2010/09/15 06:00 [entrez]
PHST- 2010/09/15 06:00 [pubmed]
PHST- 2011/02/12 06:00 [medline]
AID - ACEM863 [pii]
AID - 10.1111/j.1553-2712.2010.00863.x [doi]
PST - ppublish
SO  - Acad Emerg Med. 2010 Sep;17(9):989-90. doi: 10.1111/j.1553-2712.2010.00863.x.


PMID- 20836421
OWN - NLM
STAT- MEDLINE
DCOM- 20101102
LR  - 20100914
IS  - 1497-3715 (Print)
IS  - 1497-3715 (Linking)
VI  - 21
IP  - 3
DP  - 2010 Fall
TI  - Health care providers' perceptions of family presence during pediatric
      resuscitation.
PG  - 26-7
AB  - BACKGROUND: The Pediatric Intensive Care Unit (PICU) team strives to achieve the 
      family-centred care philosophy consistent with the organization's vision and
      mission. In 2006, a team of nurses began exploration of the evidence on family
      presence during pediatric resuscitation with the primary goal to integrate this
      knowledge into practice. From the literature search, it was apparent there was
      limited published research, especially in a Canadian pediatric setting. This led 
      to a staged research project to explore and, subsequently, integrate family
      presence during resuscitation into the culture. OBJECTIVES: 1) To explore health 
      care providers' perceptions of family presence during pediatric resuscitation
      (2007), 2) Based on these findings, develop and integrate a guideline to best
      support this practice (2008-2009), and 3) Re-examine health care providers'
      perceptions post guideline implementation (2010). METHODOLOGY: Following approval
      from the University of Manitoba nursing and education ethics review board and the
      site research coordinating committee, survey methodology was used to gather data 
      at baseline (2007) and again post implementation (2010). Data were analyzed
      independently at each time interval and then in comparison to explore the
      quantitative and qualitative responses. FINDINGS: In 2007, data demonstrated
      sufficient support to move this project forward. In addition, the survey
      indentified facilitators and barriers to assist in both the development of an
      evidence-based guideline and the successful integration into practice. In 2010,
      the post-implementation survey supported the evidenced-based practice guideline
      had achieved its goal of integration into practice.
FAU - Plouffe, Jannell A
AU  - Plouffe JA
AD  - Pediatric Intensive Care Unit, Winnipeg Children's Hospital, MB.
FAU - Cooper, Helen
AU  - Cooper H
FAU - Fraser, Kim
AU  - Fraser K
FAU - Launder, Susan
AU  - Launder S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Canada
TA  - Dynamics
JT  - Dynamics (Pembroke, Ont.)
JID - 100955578
MH  - Attitude of Health Personnel
MH  - Child
MH  - *Evidence-Based Nursing
MH  - Family/*psychology
MH  - Humans
MH  - Intensive Care Units, Pediatric/*organization & administration
MH  - Manitoba
MH  - Nursing Methodology Research
MH  - Organizational Policy
MH  - *Practice Guidelines as Topic
MH  - Professional-Family Relations
MH  - Resuscitation/nursing/*psychology
MH  - Visitors to Patients/*psychology
EDAT- 2010/09/15 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/09/15 06:00
PHST- 2010/09/15 06:00 [entrez]
PHST- 2010/09/15 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
PST - ppublish
SO  - Dynamics. 2010 Fall;21(3):26-7.


PMID- 20836415
OWN - NLM
STAT- MEDLINE
DCOM- 20100928
LR  - 20131121
IS  - 0002-7979 (Print)
IS  - 0002-7979 (Linking)
VI  - 77
IP  - 2
DP  - 2010 Summer
TI  - Ethical considerations in the use of nitrous oxide in pediatric dentistry.
PG  - 40-7
AB  - Nitrous oxide (N2O) has become a routine intervention in contemporary American
      dental practice, especially in the management of children. However, routines
      translate to confidence which in turn may lead to overconfidence, such that
      possible risks and misuses are insufficiently acknowledged. This article
      ethically evaluates the use of nitrous oxide as a practice routine in treating
      children. Nitrous oxide administration is analyzed in reference to three
      internationally acknowledged principles of dental ethics: nonmaleficence,
      beneficence, and patient autonomy. In reference to the principle of
      nonmaleficence, the potential for adverse effects of N2O is discussed,
      particularly when it is administered in conjunction with other sedatives and
      anesthetics. The importance of abiding by clinical protocols is emphasized. Next,
      in reference to the principle of beneficence, the authors address the problematic
      application of N2O for the benefit of individuals other than the patient (e.g.,
      dentists and parents). Finally, the importance of respecting patient autonomy is 
      discussed, specifically the need to obtain explicit consent for N2O. The article 
      supports the continued use of nitrous oxide but advises greater attention to how 
      and why it is administered. Four recommendations are offered for an ethically
      sound usage.
FAU - Levering, Nicholas J
AU  - Levering NJ
AD  - Department of Pediatric Dentistry, Creighton University, Omaha, NE, USA.
      nicholaslevering@creighton.edu
FAU - Welie, Jos V M
AU  - Welie JV
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Coll Dent
JT  - The Journal of the American College of Dentists
JID - 7503057
RN  - 0 (Anesthetics, Inhalation)
RN  - K50XQU1029 (Nitrous Oxide)
SB  - IM
MH  - Anesthesia, Dental/*ethics
MH  - *Anesthetics, Inhalation/adverse effects
MH  - Beneficence
MH  - Child
MH  - Conscious Sedation/*ethics
MH  - Dental Care for Children/*ethics
MH  - *Ethics, Dental
MH  - Humans
MH  - Informed Consent
MH  - *Nitrous Oxide/adverse effects
MH  - Parenting
MH  - Patient Rights
MH  - Risk Assessment
EDAT- 2010/09/15 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/09/15 06:00
PHST- 2010/09/15 06:00 [entrez]
PHST- 2010/09/15 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
PST - ppublish
SO  - J Am Coll Dent. 2010 Summer;77(2):40-7.


PMID- 20836349
OWN - NLM
STAT- MEDLINE
DCOM- 20101005
LR  - 20100914
IS  - 0003-1348 (Print)
IS  - 0003-1348 (Linking)
VI  - 76
IP  - 9
DP  - 2010 Sep
TI  - In defense of industry-physician relationships.
PG  - 987-94
AB  - The objective was to examine the economic, ethical, and legal foundations for
      conflict of interest restrictions between physicians and pharmaceutical and
      medical device industries ("industry"). Recently academic medical centers and
      professional organizations have adopted policies that restrict permissible
      interactions between industry and physicians. The motive is to avoid financial
      conflicts of interest that compromise core values of altruism and fiduciary
      relationships. Productive relationships between industry and physicians provide
      novel drugs and devices of immense benefit to society. The issues are opposing
      views of medical economics, profit motives, medical professionalism, and extent
      to which interactions should be lawfully restricted. Industry goals are congruent
      with those of physicians: patient welfare, safety, and running a profitable
      business. Profits are necessary to develop drugs and devices. Physician
      collaborators invent products, refine them, and provide feedback and so are
      appropriately paid. Marketing is necessary to bring approved products to
      patients. Economic realities limit the extent to which physicians treat their
      patients altruistically and as fiduciaries. Providing excellent service to
      patients may be a more realistic standard. Statements from industry and the
      American College of Surgeons appropriately guide professional behavior.
      Preservation of industry-physician relationships is vital to maintain medical
      innovation and progress.
FAU - Nakayama, Don K
AU  - Nakayama DK
LA  - eng
PT  - Editorial
PL  - United States
TA  - Am Surg
JT  - The American surgeon
JID - 0370522
SB  - IM
MH  - Biomedical Technology/*ethics
MH  - Codes of Ethics
MH  - *Conflict of Interest
MH  - Economics, Medical
MH  - Humans
MH  - Interprofessional Relations/*ethics
MH  - Marketing
MH  - Physicians/*ethics
MH  - Technology, Pharmaceutical/ethics
MH  - United States
EDAT- 2010/09/15 06:00
MHDA- 2010/10/06 06:00
CRDT- 2010/09/15 06:00
PHST- 2010/09/15 06:00 [entrez]
PHST- 2010/09/15 06:00 [pubmed]
PHST- 2010/10/06 06:00 [medline]
PST - ppublish
SO  - Am Surg. 2010 Sep;76(9):987-94.


PMID- 20835673
OWN - NLM
STAT- MEDLINE
DCOM- 20101223
LR  - 20190911
IS  - 0034-7167 (Print)
IS  - 0034-7167 (Linking)
VI  - 63
IP  - 4
DP  - 2010 Jul-Aug
TI  - [Reflections on nursing assistance provided to the parturient].
PG  - 652-9
LID - S0034-71672010000400023 [pii]
AB  - The objective of this bibliographic study is to identify the state of the art of 
      production published in the area of obstetrics nursing involving the birth
      process, to contribute to future investigations, and to assist in reflection upon
      this theme. Data was collected through the bibliographic analysis of the LILACS, 
      MEDLINE, Cochrane Library, and SciELO databases. Descriptors used:
      nurse-midwives, childbirth work, normal childbirth, and Nursing care. Five
      studies were selected and later catalogued in bibliographic files. The themes
      selected were: professional regulation, care, assistance given, link established,
      educational actions, administrative activities, and difficulties. While the
      studies recognize this professional as a capacitated, legally backed professional
      who offers humanized assistance and thus reaffirms normal vaginal delivery, thus 
      proportioning dignity, security, and autonomy to the delivering mother much still
      needs to written in order for the same autonomy and ethical-legal respect is
      acquired for health care professionals and clientele.
FAU - Velho, Manuela Beatriz
AU  - Velho MB
AD  - Departamento de Enfermagem, Universidade Federal de Santa Catarina,
      Florianopolis, SC. manuelavelho@hotmail.com
FAU - de Oliveira, Maria Emilia
AU  - de Oliveira ME
FAU - dos Santos, Evanguelia Kotzias Atherino
AU  - dos Santos EK
LA  - por
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Reflexoes sobre a assistencia de enfermagem prestada a parturiente.
PL  - Brazil
TA  - Rev Bras Enferm
JT  - Revista brasileira de enfermagem
JID - 7910105
MH  - Female
MH  - Humans
MH  - *Labor, Obstetric
MH  - *Obstetric Nursing
MH  - Pregnancy
EDAT- 2010/09/14 06:00
MHDA- 2010/12/25 06:00
CRDT- 2010/09/14 06:00
PHST- 2009/11/25 00:00 [received]
PHST- 2010/06/19 00:00 [accepted]
PHST- 2010/09/14 06:00 [entrez]
PHST- 2010/09/14 06:00 [pubmed]
PHST- 2010/12/25 06:00 [medline]
AID - S0034-71672010000400023 [pii]
AID - 10.1590/s0034-71672010000400023 [doi]
PST - ppublish
SO  - Rev Bras Enferm. 2010 Jul-Aug;63(4):652-9. doi: 10.1590/s0034-71672010000400023.


PMID- 20835672
OWN - NLM
STAT- MEDLINE
DCOM- 20101223
LR  - 20190911
IS  - 0034-7167 (Print)
IS  - 0034-7167 (Linking)
VI  - 63
IP  - 4
DP  - 2010 Jul-Aug
TI  - [Philosophical and theoretical basis for new conceptions of nursing care:
      contribution of the social poetic].
PG  - 644-51
LID - S0034-71672010000400022 [pii]
AB  - This work identifies the application of the philosophical and theoretical basis
      of the social poetic in new conceptions of nursing care. Systematic review of 30 
      research works. Delimited categories: Dialogue in taking care of as technological
      instrument; To take care of in nursing as not invasive technology. In the new
      conceptions of to take care the client is considered the main target of the work 
      in health. It was concluded that the social poetic basis were applied disclosing 
      a perspective on the ethics of to take care, translated into respect with the
      clients and your knowledge for the self care, leads to the autonomy and
      solidarity between clients and professionals. The social poetic, as research
      method and social practice, discloses orienting aspects of a new perspective to
      be developed in nursing take care of.
FAU - dos Santos, Iraci
AU  - dos Santos I
AD  - Departamento de Enfermagem, Universidade do Estado do Rio de Janeiro, Rio de
      Janeiro, RJ. jjosis@uerj.br
FAU - Alves, Aila Cristina dos Santos
AU  - Alves AC
FAU - Silva, Fabiola Soares
AU  - Silva FS
FAU - Penna, Lucia Helena Garcia
AU  - Penna LH
FAU - Alvin, Neide Aparecida Titonelli
AU  - Alvin NA
LA  - por
PT  - Journal Article
PT  - Review
PT  - Systematic Review
TT  - Fundamentos filosoficos e teoricos para novas concepcoes do cuidar em enfermagem:
      contribuicao da sociopoetica.
PL  - Brazil
TA  - Rev Bras Enferm
JT  - Revista brasileira de enfermagem
JID - 7910105
MH  - *Nursing Theory
MH  - *Philosophy, Nursing
EDAT- 2010/09/14 06:00
MHDA- 2010/12/25 06:00
CRDT- 2010/09/14 06:00
PHST- 2009/01/27 00:00 [received]
PHST- 2010/06/08 00:00 [accepted]
PHST- 2010/09/14 06:00 [entrez]
PHST- 2010/09/14 06:00 [pubmed]
PHST- 2010/12/25 06:00 [medline]
AID - S0034-71672010000400022 [pii]
AID - 10.1590/s0034-71672010000400022 [doi]
PST - ppublish
SO  - Rev Bras Enferm. 2010 Jul-Aug;63(4):644-51. doi: 10.1590/s0034-71672010000400022.


PMID- 20835659
OWN - NLM
STAT- MEDLINE
DCOM- 20101223
LR  - 20190911
IS  - 0034-7167 (Print)
IS  - 0034-7167 (Linking)
VI  - 63
IP  - 4
DP  - 2010 Jul-Aug
TI  - [Linkages and challenges in the training of professional nurses].
PG  - 555-60
LID - S0034-71672010000400009 [pii]
AB  - The objective of the study was to know the linkages and challenges between
      professional training and practice and the Curriculum Guidelines for Nursing
      Baccalaureate Degree Programs. It was a qualitative study, with 34 graduates in
      nursing, who answered an e-mailed questionnaire. Data analysis was based on
      Michael Foucault's discourse analysis. The ethical aspects were observed.
      Analysis showed three themes in graduates discourses - Unified Health System,
      generalist professional training and humanization. The study revealed an
      approximation of concepts and guidelines of the Curriculum Guidelines for Nursing
      Baccalaureate Degree Programs and of the Unified Health System with the reality
      of professional practice along with challenges in the training of professional
      nurses.
FAU - Corbellini, Valeria Lamb
AU  - Corbellini VL
AD  - Universidade Catolica do Rio Grande do Sul, Porto Alegre, RS.
      vlamb@pucrs.brPontificia
FAU - Lara dos Santos, Beatriz Regina
AU  - Lara dos Santos BR
FAU - Ojeda, Beatriz Sebben
AU  - Ojeda BS
FAU - Gerhart, Luiza Maria
AU  - Gerhart LM
FAU - Eidt, Olga Rosaria
AU  - Eidt OR
FAU - Stein, Sarah Ceolin
AU  - Stein SC
FAU - Teixeira de Mello, Denise
AU  - Teixeira de Mello D
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Nexos e desafios na formacao profissional do enfermeiro.
PL  - Brazil
TA  - Rev Bras Enferm
JT  - Revista brasileira de enfermagem
JID - 7910105
MH  - Curriculum
MH  - Education, Nursing/*standards
EDAT- 2010/09/14 06:00
MHDA- 2010/12/25 06:00
CRDT- 2010/09/14 06:00
PHST- 2009/01/03 00:00 [received]
PHST- 2010/05/19 00:00 [accepted]
PHST- 2010/09/14 06:00 [entrez]
PHST- 2010/09/14 06:00 [pubmed]
PHST- 2010/12/25 06:00 [medline]
AID - S0034-71672010000400009 [pii]
AID - 10.1590/s0034-71672010000400009 [doi]
PST - ppublish
SO  - Rev Bras Enferm. 2010 Jul-Aug;63(4):555-60. doi: 10.1590/s0034-71672010000400009.


PMID- 20835652
OWN - NLM
STAT- MEDLINE
DCOM- 20101223
LR  - 20220311
IS  - 0034-7167 (Print)
IS  - 0034-7167 (Linking)
VI  - 63
IP  - 4
DP  - 2010 Jul-Aug
TI  - [Depression among students from two nursing undergraduate programs:
      self-assessment on health and associated factors].
PG  - 509-16
LID - S0034-71672010000400002 [pii]
AB  - UNLABELLED: This study aimed to verify the prevalence of depression and
      associated factors among undergraduate nursing students. Descriptive research
      carried out in Ribeirao Preto with students from two undergraduate programs.
      INSTRUMENTS: Brazilian Economic Classification Criteria; Beck Depression
      Inventory; Quality of Life Assessment. It was performed bivariate and
      multivariate analysis of data. Ethical procedures were respected. Among the 114
      subjects, most are women and single. Bachelor Program: 32% are aged less than 20 
      years old, from economic levels A2, B1 and B2 and 69,6% do not work. Teaching
      Diploma Program: 32,6% older than 25 years old, levels B2 and C and 75,8% work.
      Depression detected in 15,4% of the students at Bachelor's Program and 28,6% from
      the Teaching Diploma Program. The percentage of depression decreases as Teaching 
      Diploma Program students' economical level increases. Mental self assessment
      carried out by student and program enrolled had significant prevalence rates.
FAU - Furegato, Antonia Regina Ferreira
AU  - Furegato AR
AD  - Departamento de Enfermagem Psiquiatrica e Ciencias Humanas, Universidade de Sao
      Paulo, Ribeirao Preto, SP. furegato@eerp.usp.br
FAU - Santos, Jair Licio Ferreira
AU  - Santos JL
FAU - Cristina da Silva, Edilaine
AU  - Cristina da Silva E
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Depressao entre estudantes de dois cursos de enfermagem: autoavaliacao da saude e
      fatores associados.
PL  - Brazil
TA  - Rev Bras Enferm
JT  - Revista brasileira de enfermagem
JID - 7910105
MH  - Adult
MH  - Depression/*epidemiology
MH  - *Diagnostic Self Evaluation
MH  - Female
MH  - Humans
MH  - Male
MH  - Prevalence
MH  - Socioeconomic Factors
MH  - *Students, Nursing
MH  - Young Adult
EDAT- 2010/09/14 06:00
MHDA- 2010/12/25 06:00
CRDT- 2010/09/14 06:00
PHST- 2008/12/12 00:00 [received]
PHST- 2010/05/05 00:00 [accepted]
PHST- 2010/09/14 06:00 [entrez]
PHST- 2010/09/14 06:00 [pubmed]
PHST- 2010/12/25 06:00 [medline]
AID - S0034-71672010000400002 [pii]
AID - 10.1590/s0034-71672010000400002 [doi]
PST - ppublish
SO  - Rev Bras Enferm. 2010 Jul-Aug;63(4):509-16. doi: 10.1590/s0034-71672010000400002.


PMID- 20835634
OWN - NLM
STAT- MEDLINE
DCOM- 20111003
LR  - 20190918
IS  - 1806-9282 (Electronic)
IS  - 0104-4230 (Linking)
VI  - 56
IP  - 4
DP  - 2010 Jul-Aug
TI  - Ethical issues of diagnosis disclosure and treatment in patients with genital or 
      breast cancer.
PG  - 397-402
LID - S0104-42302010000400010 [pii]
AB  - OBJECTIVE: To verify how communication between physicians and patients takes
      place during diagnosis, treatment and prognosis of women with genital or breast
      cancer, using bioethics as a reference for analysis. METHODS:
      Descriptive/analytical epidemiological cross-sectional study of 120 patients
      randomly selected at Hospital de Base do Distrito Federal, Brazil. Patients were 
      given a questionnaire with nine closed-ended questions distributed as follows:
      three related to diagnosis, four to treatment, and two to prognosis. RESULTS: The
      results showed that 73.3% of patients considered the quality of initial
      information received on the diagnosis of cancer as "negative"; 54.2% of patients 
      understood information received on diagnosis and treatment; approximately 60%
      were aware of the prognosis of cancer; and less than 10% did not want additional 
      information. However, for almost 40% of respondents, there was a problem in
      physician-patient communication regarding the process involving cancer. Age and
      extent of the disease did not influence the patients' degree of understanding
      about diagnosis, treatment, and prognosis. CONCLUSION: Communicating information 
      about diagnosis, treatment and prognosis to patients with genital or breast
      cancer was adequate in about 60% of cases. However, problems were detected
      concerning the language used by physicians, lack of systematic consideration
      towards patient autonomy, and absence of mechanisms that could provide
      decision-making power to patients.
FAU - Primo, Walquiria Quida Salles Pereira
AU  - Primo WQ
AD  - Hospital de Base do Distrito Federal, Brasilia, DF, Brazil.
      walquiriaqspp@uol.com.br
FAU - Garrafa, Volnei
AU  - Garrafa V
LA  - eng
LA  - por
PT  - Journal Article
PL  - Brazil
TA  - Rev Assoc Med Bras (1992)
JT  - Revista da Associacao Medica Brasileira (1992)
JID - 9308586
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Bioethical Issues
MH  - Brazil
MH  - Breast Neoplasms/*diagnosis/psychology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Genital Neoplasms, Female/*diagnosis/psychology
MH  - Humans
MH  - Middle Aged
MH  - Physician-Patient Relations/*ethics
MH  - Prognosis
MH  - Surveys and Questionnaires
MH  - Truth Disclosure/*ethics
EDAT- 2010/09/14 06:00
MHDA- 2011/10/04 06:00
CRDT- 2010/09/14 06:00
PHST- 2009/10/30 00:00 [received]
PHST- 2010/04/12 00:00 [accepted]
PHST- 2010/09/14 06:00 [entrez]
PHST- 2010/09/14 06:00 [pubmed]
PHST- 2011/10/04 06:00 [medline]
AID - S0104-42302010000400010 [pii]
AID - 10.1590/s0104-42302010000400010 [doi]
PST - ppublish
SO  - Rev Assoc Med Bras (1992). 2010 Jul-Aug;56(4):397-402. doi:
      10.1590/s0104-42302010000400010.


PMID- 20835398
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 1871-4757 (Print)
IS  - 1871-4757 (Linking)
VI  - 4
IP  - 2
DP  - 2010 Aug
TI  - The Ambivalence of Promising Technology.
PG  - 183-189
AB  - Issues of responsibility in the world of nanotechnology are becoming explicit
      with the emergence of a discourse on 'responsible development' of nanoscience and
      nanotechnologies. Much of this discourse centres on the ambivalences of
      nanotechnology and of promising technology in general. Actors must find means of 
      dealing with these ambivalences. Actors' actions and responses to ambivalence are
      shaped by their position and context, along with strategic games they are
      involved in, together with other actors. A number of interviews were conducted
      with industrial actors with the aim of uncovering their ethical stances towards
      responsible development of nanotechnology. The data shows that standard
      repertoires of justification of nanotechnological development were used. Thus,
      the industrial actors fell back on their position and associated
      responsibilities. Such responses reinforce a division of moral labour in which
      industrial actors and scientists can focus on the progress of science and
      technology, while other actors, such as NGOs, are expected to take care of
      broader considerations, such as ethical and social issues.
FAU - Shelley-Egan, Clare
AU  - Shelley-Egan C
AD  - Department of Science, Technology and Policy Studies, University of Twente,
      Enschede, Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20100817
PL  - Netherlands
TA  - Nanoethics
JT  - Nanoethics
JID - 101311055
PMC - PMC2933805
EDAT- 2010/09/14 06:00
MHDA- 2010/09/14 06:01
CRDT- 2010/09/14 06:00
PHST- 2010/07/26 00:00 [received]
PHST- 2010/07/26 00:00 [accepted]
PHST- 2010/09/14 06:00 [entrez]
PHST- 2010/09/14 06:00 [pubmed]
PHST- 2010/09/14 06:01 [medline]
AID - 10.1007/s11569-010-0099-2 [doi]
PST - ppublish
SO  - Nanoethics. 2010 Aug;4(2):183-189. doi: 10.1007/s11569-010-0099-2. Epub 2010 Aug 
      17.


PMID- 20835397
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 1871-4757 (Print)
IS  - 1871-4757 (Linking)
VI  - 4
IP  - 2
DP  - 2010 Aug
TI  - Sunscreens with Titanium Dioxide (TiO(2)) Nano-Particles: A Societal Experiment.
PG  - 103-113
AB  - The risks of novel technologies, such as nano(bio)technology cannot be fully
      assessed due to the existing uncertainties surrounding their introduction into
      society. Consequently, the introduction of innovative technologies can be
      conceptualised as a societal experiment, which is a helpful approach to evaluate 
      moral acceptability. This approach is illustrated with the marketing of
      sunscreens containing nano-sized titanium dioxide (TiO(2)) particles. We argue
      that the marketing of this TiO(2) nanomaterial in UV protective cosmetics is
      ethically undesirable, since it violates four reasonable moral conditions for
      societal experimentation (absence of alternatives, controllability, limited
      informed consent, and continuing evaluation). To remedy the current way
      nano-sized TiO(2) containing sunscreens are utilised, we suggest five
      complementing actions (closing the gap, setup monitoring tools, continuing
      review, designing for safety, and regulative improvements) so that its marketing 
      can become more acceptable.
FAU - Jacobs, Johannes F
AU  - Jacobs JF
FAU - van de Poel, Ibo
AU  - van de Poel I
FAU - Osseweijer, Patricia
AU  - Osseweijer P
LA  - eng
PT  - Journal Article
DEP - 20100620
PL  - Netherlands
TA  - Nanoethics
JT  - Nanoethics
JID - 101311055
PMC - PMC2933802
EDAT- 2010/09/14 06:00
MHDA- 2010/09/14 06:01
CRDT- 2010/09/14 06:00
PHST- 2009/11/30 00:00 [received]
PHST- 2010/05/17 00:00 [accepted]
PHST- 2010/09/14 06:00 [entrez]
PHST- 2010/09/14 06:00 [pubmed]
PHST- 2010/09/14 06:01 [medline]
AID - 10.1007/s11569-010-0090-y [doi]
PST - ppublish
SO  - Nanoethics. 2010 Aug;4(2):103-113. doi: 10.1007/s11569-010-0090-y. Epub 2010 Jun 
      20.


PMID- 20835258
OWN - NLM
STAT- MEDLINE
DCOM- 20110211
LR  - 20211020
IS  - 1745-7262 (Electronic)
IS  - 1008-682X (Linking)
VI  - 12
IP  - 6
DP  - 2010 Nov
TI  - Ethical issues in penile transplantation.
PG  - 795-800
LID - 10.1038/aja.2010.88 [doi]
AB  - This article provides an overview of the ethical issues associated with penile
      transplantation, a form of composite tissue allografting. There is only one
      reported case of human penile transplantation, and, as such, this technique is
      considered to be experimental. The ethical issues at stake involve both the graft
      donor and the graft recipient. With regard to the recipient, there are
      significant concerns relating to surgical risks and benefits, informed consent,
      body image (including surgical expectations and outcomes) and compliance. Donor
      issues may include family consent and privacy, as well as graft harvesting
      (leaving the donor cadaver without a penis). Many of these ethical issues can be 
      explored during the recipient's assessment and consent process. Because no
      medium-term or long-term outcome data for this procedure exist-only one such
      operation has ever been performed-the burdens and ethical issues concerning
      penile transplantation remain unknown.
FAU - Zhang, Li-Chao
AU  - Zhang LC
AD  - Department of Urology, Guangzhou General Hospital of Guangzhou Military Command, 
      Guangzhou 510010, China.
FAU - Zhao, Yong-Bing
AU  - Zhao YB
FAU - Hu, Wei-Lie
AU  - Hu WL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100913
PL  - China
TA  - Asian J Androl
JT  - Asian journal of andrology
JID - 100942132
SB  - IM
MH  - Humans
MH  - Informed Consent
MH  - Male
MH  - Penis/injuries/surgery/*transplantation
MH  - Privacy
MH  - Replantation
MH  - Tissue Donors
MH  - Transplantation, Homologous/*ethics/psychology
PMC - PMC3739079
EDAT- 2010/09/14 06:00
MHDA- 2011/02/12 06:00
CRDT- 2010/09/14 06:00
PHST- 2010/09/14 06:00 [entrez]
PHST- 2010/09/14 06:00 [pubmed]
PHST- 2011/02/12 06:00 [medline]
AID - aja201088 [pii]
AID - 10.1038/aja.2010.88 [doi]
PST - ppublish
SO  - Asian J Androl. 2010 Nov;12(6):795-800. doi: 10.1038/aja.2010.88. Epub 2010 Sep
      13.


PMID- 20834070
OWN - NLM
STAT- MEDLINE
DCOM- 20110201
LR  - 20180607
IS  - 1512-0112 (Print)
IS  - 1512-0112 (Linking)
IP  - 184-185
DP  - 2010 Jul-Aug
TI  - Science and conscience.
PG  - 7-20
AB  - Many historical facts, describing exploitation and discrimination of research
      subjects which have been justified by the importance of research aims, are known.
      Today the protection of the rights and safety of persons involved in biomedical
      research (research subjects) is the necessary precondition for contemporary
      biomedical researches and correspondingly, development of the science. An
      integral responsibility of researchers working in the field of biomedicine is to 
      ensure the protection of safety and rights of research subjects. In Europe, as
      well as other countries of developed and partly in developing world, there is a
      relevant legislative basis of international agreements and national legislation
      which aims at protecting the research subject. Georgia possesses considerable
      legislative basis in this field which includes two obligatory instruments of
      Council of Europe and two national laws. Relevant legislation and ethical
      evaluation of biomedical research protocols involving human subjects by research 
      ethics committees is an effective mechanism for protection of a research
      subject's safety and rights. In Georgia there already exist biomedical research
      ethics committees. Further, their amalgamation is necessary to increase their
      competence and regularity of activities through increasing the number of
      submitted research protocols as well as re-distribution of expertise (3-5
      committees instead of existing 15-20 or more committees). All the researchers
      participating in biomedical research shall be educated on the issues of
      protection of rights of research subjects and contemporary principles of
      bioethics. The latter shall become an inseparable part of professional competence
      of researchers for which it is necessary to prepare and put into practice special
      training programmes (mural as well as distant courses).
FAU - Javashvili, G
AU  - Javashvili G
FAU - Kiknadze, G
AU  - Kiknadze G
FAU - Kurtanidze, T
AU  - Kurtanidze T
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Georgia (Republic)
TA  - Georgian Med News
JT  - Georgian medical news
JID - 101218222
SB  - IM
MH  - Biomedical Research/*ethics
MH  - *Conscience
MH  - Georgia (Republic)
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - *Research Subjects
MH  - Science/*ethics
EDAT- 2010/09/14 06:00
MHDA- 2011/02/02 06:00
CRDT- 2010/09/14 06:00
PHST- 2010/09/14 06:00 [entrez]
PHST- 2010/09/14 06:00 [pubmed]
PHST- 2011/02/02 06:00 [medline]
PST - ppublish
SO  - Georgian Med News. 2010 Jul-Aug;(184-185):7-20.


PMID- 20833751
OWN - NLM
STAT- MEDLINE
DCOM- 20100927
LR  - 20181023
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 341
DP  - 2010 Sep 10
TI  - European drug agency calls for more ethical trials in developing countries.
PG  - c4984
LID - 10.1136/bmj.c4984 [doi]
LID - bmj.c4984 [pii]
FAU - Day, Michael
AU  - Day M
LA  - eng
PT  - News
DEP - 20100910
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
SB  - IM
MH  - Clinical Trials as Topic/*ethics
MH  - *Developing Countries
MH  - Drug Industry/*ethics
MH  - Humans
EDAT- 2010/09/14 06:00
MHDA- 2010/09/29 06:00
CRDT- 2010/09/14 06:00
PHST- 2010/09/14 06:00 [entrez]
PHST- 2010/09/14 06:00 [pubmed]
PHST- 2010/09/29 06:00 [medline]
AID - 10.1136/bmj.c4984 [doi]
PST - epublish
SO  - BMJ. 2010 Sep 10;341:c4984. doi: 10.1136/bmj.c4984.


PMID- 20832985
OWN - NLM
STAT- MEDLINE
DCOM- 20150713
LR  - 20181202
IS  - 1873-6513 (Electronic)
IS  - 0885-3924 (Linking)
VI  - 41
IP  - 1
DP  - 2011 Jan
TI  - Palliative sedation, not slow euthanasia: a prospective, longitudinal study of
      sedation in Flemish palliative care units.
PG  - 14-24
LID - 10.1016/j.jpainsymman.2010.04.019 [doi]
AB  - CONTEXT: Palliative sedation remains a much debated and controversial issue. The 
      limited literature on the topic often fails to answer ethical questions
      concerning this practice. OBJECTIVES: The aim of this study was to describe the
      characteristics of patients who are being sedated for refractory symptoms in
      palliative care units (PCUs) from the time of admission until the day of death.
      METHODS: A prospective, longitudinal, descriptive design was used to assess data 
      in eight PCUs. The total sample consisted of 266 patients. Information on
      demographics, medication, food and fluid intake, decision making, level of
      consciousness, and symptom experience were gathered by nurses and researchers
      three times a week. If patients received palliative sedation, extra information
      was gathered. RESULTS: Of all included patients (n=266), 7.5% received palliative
      sedation. Sedation started, on average, 2.5 days before death and for half of
      these patients, the form of sedation changed over time. At the start of sedation,
      patients were in the end stage of their illness and needed total care. Patients
      were fully conscious and had very limited oral food or fluid intake. Only three
      patients received artificial fluids at the start of sedation. Patients reported, 
      on average, two refractory symptoms, the most important ones being pain, fatigue,
      depression, drowsiness, and loss of feeling of well-being. In all cases, the
      patient gave consent to start palliative sedation because of increased suffering.
      CONCLUSION: This study revealed that palliative sedation is only administered in 
      exceptional cases where refractory suffering is evident and for those patients
      who are close to the ends of their lives. Moreover, this study supports the
      argument that palliative sedation has no life-shortening effect.
CI  - Copyright (c) 2011 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. 
      All rights reserved.
FAU - Claessens, Patricia
AU  - Claessens P
AD  - Centre for Biomedical Ethics and Law, Catholic University Leuven, Drongen,
      Belgium.
FAU - Menten, Johan
AU  - Menten J
AD  - Palliative Care Unit, University Hospitals Leuven, Leuven, Belgium.
FAU - Schotsmans, Paul
AU  - Schotsmans P
AD  - Faculty of Medicine, Catholic University Leuven, Drongen, Belgium.
FAU - Broeckaert, Bert
AU  - Broeckaert B
AD  - Interdisciplinary Centre for the Study of Religion and Worldview, Catholic
      University Leuven, Drongen, Belgium.
CN  - Palsed Consortium
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100915
PL  - United States
TA  - J Pain Symptom Manage
JT  - Journal of pain and symptom management
JID - 8605836
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Belgium/epidemiology
MH  - Comorbidity
MH  - Deep Sedation/mortality/*statistics & numerical data
MH  - Depression/*prevention & control
MH  - Euthanasia/*statistics & numerical data
MH  - Fatigue/*prevention & control
MH  - Female
MH  - Humans
MH  - Life Expectancy
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Pain/prevention & control
MH  - Palliative Care/methods/*statistics & numerical data
MH  - Prevalence
MH  - Quality of Life
MH  - Risk Factors
MH  - Stress, Psychological/*prevention & control
MH  - Survival Rate
MH  - Terminal Care/statistics & numerical data
MH  - Terminally Ill/*statistics & numerical data
MH  - Treatment Outcome
IR  - Van Imschoot L
FIR - Van Imschoot, L
IR  - Schrauwen A
FIR - Schrauwen, A
IR  - Van Belle P
FIR - Van Belle, P
IR  - Sercu K
FIR - Sercu, K
IR  - Schrijvers D
FIR - Schrijvers, D
IR  - Dekkers L
FIR - Dekkers, L
IR  - Pieters P
FIR - Pieters, P
IR  - Maja C
FIR - Maja, C
IR  - Desmet M
FIR - Desmet, M
IR  - Nelde A
FIR - Nelde, A
IR  - Vannuffelen R
FIR - Vannuffelen, R
IR  - van den Eynden B
FIR - van den Eynden, B
IR  - Pauwels E
FIR - Pauwels, E
EDAT- 2010/09/14 06:00
MHDA- 2015/07/15 06:00
CRDT- 2010/09/14 06:00
PHST- 2010/02/16 00:00 [received]
PHST- 2010/04/07 00:00 [revised]
PHST- 2010/04/16 00:00 [accepted]
PHST- 2010/09/14 06:00 [entrez]
PHST- 2010/09/14 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
AID - S0885-3924(10)00533-6 [pii]
AID - 10.1016/j.jpainsymman.2010.04.019 [doi]
PST - ppublish
SO  - J Pain Symptom Manage. 2011 Jan;41(1):14-24. doi:
      10.1016/j.jpainsymman.2010.04.019. Epub 2010 Sep 15.


PMID- 20832979
OWN - NLM
STAT- MEDLINE
DCOM- 20110121
LR  - 20101011
IS  - 1873-6513 (Electronic)
IS  - 0885-3924 (Linking)
VI  - 40
IP  - 4
DP  - 2010 Oct
TI  - Keeping the patient at the center of patient- and family-centered care.
PG  - 621-5
LID - 10.1016/j.jpainsymman.2010.06.008 [doi]
AB  - The practice of palliative care typically refers to the focus of treatment as the
      patient and family. Tending to the needs of both patients and their families is
      usually good, but what should clinicians do when they perceive the best
      interests, needs, or treatment preferences of the patient are in conflict with
      those of the family or other surrogate? Physicians may be able to suppress the
      inevitable moral cognitive dissonance of such circumstances, write orders, and
      walk away, but other health care professionals, especially nurses, may not have
      it so easy. This article suggests practical steps to obviate conflict in such
      circumstances before offering an ethical analysis focusing on notions of
      autonomy, beneficence, and true caring for patients, especially those near the
      end of life. The limitations of surrogate decision makers are considered and
      legal liability concerns are briefly explored, ultimately leading to the
      conclusion that keeping the patient at the center is sine qua non of patient- and
      family-centered care.
CI  - Copyright (c) 2010 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. 
      All rights reserved.
FAU - Fine, Robert L
AU  - Fine RL
AD  - ClinicalEthics and Palliative Care, Baylor Health Care System, Dallas, Texas
      75204, USA. robertf@baylorhealth.edu
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20100915
PL  - United States
TA  - J Pain Symptom Manage
JT  - Journal of pain and symptom management
JID - 8605836
SB  - IM
MH  - Aged
MH  - *Ethics, Medical
MH  - *Family
MH  - Humans
MH  - Male
MH  - Palliative Care/*ethics
MH  - Patient Rights/ethics
MH  - Patient-Centered Care/*ethics
EDAT- 2010/09/14 06:00
MHDA- 2011/01/22 06:00
CRDT- 2010/09/14 06:00
PHST- 2010/06/01 00:00 [received]
PHST- 2010/06/06 00:00 [accepted]
PHST- 2010/09/14 06:00 [entrez]
PHST- 2010/09/14 06:00 [pubmed]
PHST- 2011/01/22 06:00 [medline]
AID - S0885-3924(10)00573-7 [pii]
AID - 10.1016/j.jpainsymman.2010.06.008 [doi]
PST - ppublish
SO  - J Pain Symptom Manage. 2010 Oct;40(4):621-5. doi:
      10.1016/j.jpainsymman.2010.06.008. Epub 2010 Sep 15.


PMID- 20832883
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20101115
IS  - 1879-3096 (Electronic)
IS  - 0167-7799 (Linking)
VI  - 28
IP  - 12
DP  - 2010 Dec
TI  - The role of ethics in science and engineering.
PG  - 589-90
LID - 10.1016/j.tibtech.2010.08.003 [doi]
AB  - It is generally thought that science and engineering should never cross certain
      ethical lines. The idea connects ethics to science and engineering, but it frames
      the relationship in a misleading way. Moral notions and practices inevitably
      influence and are influenced by science and engineering. The important question
      is how such interactions should take place. Anticipatory ethics is a new approach
      that integrates ethics into technological development.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Johnson, Deborah G
AU  - Johnson DG
AD  - Department of Science, Technology, and Society, University of Virginia,
      Charlottesville, Virginia 22904, USA. dgj7p@virginia.edu
LA  - eng
PT  - Journal Article
PL  - England
TA  - Trends Biotechnol
JT  - Trends in biotechnology
JID - 8310903
SB  - IM
MH  - Engineering/*ethics/trends
MH  - Ethics, Professional
MH  - Humans
MH  - Science/*ethics/trends
EDAT- 2010/09/14 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/09/14 06:00
PHST- 2010/06/08 00:00 [received]
PHST- 2010/07/28 00:00 [revised]
PHST- 2010/08/09 00:00 [accepted]
PHST- 2010/09/14 06:00 [entrez]
PHST- 2010/09/14 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - S0167-7799(10)00139-3 [pii]
AID - 10.1016/j.tibtech.2010.08.003 [doi]
PST - ppublish
SO  - Trends Biotechnol. 2010 Dec;28(12):589-90. doi: 10.1016/j.tibtech.2010.08.003.


PMID- 20832533
OWN - NLM
STAT- MEDLINE
DCOM- 20110225
LR  - 20211203
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 42
IP  - 7
DP  - 2010 Sep
TI  - Correlation between HLA and posttransplantation diabetes mellitus in the Han
      population in South China.
PG  - 2509-12
LID - 10.1016/j.transproceed.2010.04.029 [doi]
AB  - BACKGROUND: Posttransplantation diabetes mellitus (PTDM) is a common metabolic
      complication in renal transplant recipients. Some studies have revealed
      predisposing or protective HLA genes for PTDM. OBJECTIVE: To describe the
      characteristics of PTDM in patients in the south of China. METHODS: The present
      study included 195 living-donor kidney transplant recipients. Informed consent
      was obtained from all participants, and the study was approved by our
      Institutional Ethics Committee. Each donor-recipient pair was related. Twenty-two
      patients had PTDM, whereas 173 did not. The frequency of each HLA phenotype was
      compared between these 2 groups. The 195 patients were divided into 2 groups
      according to immunosuppression regimen, a cyclosporine group and a tacrolimus
      group, and the incidence of PTDM was compared between the groups. Patients were
      then subdivided into 2 groups according to age, an elderly group (age 40 years or
      older) and a younger group (age younger than 40 years), and the incidence of PTDM
      was calculated and compared between these 2 groups. RESULTS: HLA-A30 and HLA-DR7 
      seem to be predisposing genes for PTDM in patients in the south of China; Low
      dosages of calcineurin inhibitors were used in our center, There was no
      significant difference in the incidence of PTDM between the CsA and Tac groups;
      The incidence of PTDM in the elderly group was significantly higher than that in 
      the younger group. CONCLUSION: Patients receiving HLA-A30 and HLA-DR7 antigens,
      and elderly patients are at higher risk of developing PTDM. Tacrolimus does not
      significantly increase the incidence of PTDM.
CI  - 2010. Published by Elsevier Inc. All rights reserved.
FAU - Yu, S J
AU  - Yu SJ
AD  - Second Xiang-Ya Hospital, Central South University, Changsha, China.
FAU - Peng, L
AU  - Peng L
FAU - Xie, X B
AU  - Xie XB
FAU - Peng, F H
AU  - Peng FH
FAU - Fang, C H
AU  - Fang CH
FAU - Wang, Y
AU  - Wang Y
FAU - Lan, G B
AU  - Lan GB
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - 0 (Blood Glucose)
RN  - 0 (HLA Antigens)
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Adult
MH  - Asians
MH  - Blood Glucose/metabolism
MH  - China/epidemiology
MH  - Diabetes Mellitus/blood/*epidemiology/genetics/immunology
MH  - Drug Therapy, Combination
MH  - Genetic Predisposition to Disease
MH  - HLA Antigens/*blood
MH  - Humans
MH  - Immunosuppressive Agents/therapeutic use
MH  - Incidence
MH  - Kidney Transplantation/adverse effects/*immunology
MH  - Living Donors
MH  - Postoperative Complications/*epidemiology
EDAT- 2010/09/14 06:00
MHDA- 2011/02/26 06:00
CRDT- 2010/09/14 06:00
PHST- 2009/02/17 00:00 [received]
PHST- 2009/05/28 00:00 [revised]
PHST- 2010/04/16 00:00 [accepted]
PHST- 2010/09/14 06:00 [entrez]
PHST- 2010/09/14 06:00 [pubmed]
PHST- 2011/02/26 06:00 [medline]
AID - S0041-1345(10)00892-4 [pii]
AID - 10.1016/j.transproceed.2010.04.029 [doi]
PST - ppublish
SO  - Transplant Proc. 2010 Sep;42(7):2509-12. doi: 10.1016/j.transproceed.2010.04.029.


PMID- 20831914
OWN - NLM
STAT- MEDLINE
DCOM- 20110124
LR  - 20211020
IS  - 1873-2518 (Electronic)
IS  - 0264-410X (Linking)
VI  - 28
IP  - 45
DP  - 2010 Oct 21
TI  - Candidate hepatitis C vaccine trials and people who inject drugs: challenges and 
      opportunities.
PG  - 7273-8
LID - 10.1016/j.vaccine.2010.08.085 [doi]
AB  - People who inject drugs (PWID) are at high risk of HCV. Limited evidence of the
      effectiveness of prevention interventions and low uptake of treatment in this
      group highlight the need for increased investment in biomedical interventions,
      notably safe and efficacious vaccines. While several candidates are currently in 
      development, field trials in PWID present challenges, including ethical issues
      associated with trial literacy, informed consent and standards of care.
      Significant biological and social factors and differences between HIV and HCV
      suggest that HCV warrants targeted vaccine preparedness research to lay the
      groundwork for successful implementation of future trials.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Maher, Lisa
AU  - Maher L
AD  - National Centre in HIV Epidemiology and Clinical Research, School of Public
      Health and Community Medicine, University of New South Wales, Centre for
      Immunology, Darlinghurst, NSW 2010, Australia. LMaher@nchecr.unsw.edu.au
FAU - White, Bethany
AU  - White B
FAU - Hellard, Margaret
AU  - Hellard M
FAU - Madden, Annie
AU  - Madden A
FAU - Prins, Maria
AU  - Prins M
FAU - Kerr, Thomas
AU  - Kerr T
FAU - Page, Kimberly
AU  - Page K
LA  - eng
GR  - 5 U19 AI40034-13/AI/NIAID NIH HHS/United States
GR  - CAPMC/ CIHR/Canada
GR  - R01 DA016017/DA/NIDA NIH HHS/United States
GR  - U19 AI040034/AI/NIAID NIH HHS/United States
GR  - 2 R01 DA016017-03A1/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100909
PL  - Netherlands
TA  - Vaccine
JT  - Vaccine
JID - 8406899
RN  - 0 (Viral Hepatitis Vaccines)
SB  - IM
MH  - Clinical Trials as Topic/*ethics
MH  - *Drug Users
MH  - Hepatitis C/*prevention & control
MH  - Humans
MH  - Informed Consent/ethics
MH  - Standard of Care
MH  - Viral Hepatitis Vaccines/*administration & dosage
PMC - PMC3729933
MID - NIHMS453954
EDAT- 2010/09/14 06:00
MHDA- 2011/01/25 06:00
CRDT- 2010/09/14 06:00
PHST- 2010/05/19 00:00 [received]
PHST- 2010/08/17 00:00 [revised]
PHST- 2010/08/24 00:00 [accepted]
PHST- 2010/09/14 06:00 [entrez]
PHST- 2010/09/14 06:00 [pubmed]
PHST- 2011/01/25 06:00 [medline]
AID - S0264-410X(10)01267-3 [pii]
AID - 10.1016/j.vaccine.2010.08.085 [doi]
PST - ppublish
SO  - Vaccine. 2010 Oct 21;28(45):7273-8. doi: 10.1016/j.vaccine.2010.08.085. Epub 2010
      Sep 9.


PMID- 20831782
OWN - NLM
STAT- MEDLINE
DCOM- 20110216
LR  - 20220408
IS  - 1741-7015 (Electronic)
IS  - 1741-7015 (Linking)
VI  - 8
DP  - 2010 Sep 10
TI  - Routine resite of peripheral intravenous devices every 3 days did not reduce
      complications compared with clinically indicated resite: a randomised controlled 
      trial.
PG  - 53
LID - 10.1186/1741-7015-8-53 [doi]
AB  - BACKGROUND: Peripheral intravenous device (IVD) complications were traditionally 
      thought to be reduced by limiting dwell time. Current recommendations are to
      resite IVDs by 96 hours with the exception of children and patients with poor
      veins. Recent evidence suggests routine resite is unnecessary, at least if
      devices are inserted by a specialised IV team. The aim of this study was to
      compare the impact of peripheral IVD 'routine resite' with 'removal on clinical
      indication' on IVD complications in a general hospital without an IV team.
      METHODS: A randomised, controlled trial was conducted in a regional teaching
      hospital. After ethics approval, 362 patients (603 IVDs) were randomised to have 
      IVDs replaced on clinical indication (185 patients) or routine change every 3
      days (177 patients). IVDs were inserted and managed by the general hospital
      medical and nursing staff; there was no IV team. The primary endpoint was a
      composite of IVD complications: phlebitis, infiltration, occlusion, accidental
      removal, local infection, and device-related bloodstream infection. RESULTS: IVD 
      complication rates were 68 per 1,000 IVD days (clinically indicated) and 66 per
      1,000 IVD days (routine replacement) (P = 0.86; HR 1.03; 95% CI, 0.74-1.43). Time
      to first complication per patient did not differ between groups (KM with log
      rank, P = 0.53). There were no local infections or IVD-related bloodstream
      infections in either group. IV therapy duration did not differ between groups (P 
      = 0.22), but more (P = 0.004) IVDs were placed per patient in the routine
      replacement (mean, 1.8) than the clinical indication group (mean, 1.5), with
      significantly higher hospital costs per patient (P < 0.001). CONCLUSIONS: Resite 
      on clinical indication would allow one in two patients to have a single cannula
      per course of IV treatment, as opposed to one in five patients managed with
      routine resite; overall complication rates appear similar. Clinically indicated
      resite would achieve savings in equipment, staff time and patient discomfort.
      There is growing evidence to support the extended use of peripheral IVDs with
      removal only on clinical indication. REGISTRATION NUMBER: Australian New Zealand 
      Clinical Trials Registry (ANZCTR) Number ACTRN12608000421336.
FAU - Rickard, Claire M
AU  - Rickard CM
AD  - Research Centre for Clinical and Community Practice Innovation, Griffith
      University, 170 Kessels Rd, Nathan Qld 4111, Australia. c.rickard@griffith.edu.au
FAU - McCann, Damhnat
AU  - McCann D
FAU - Munnings, Jane
AU  - Munnings J
FAU - McGrail, Matthew R
AU  - McGrail MR
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20100910
PL  - England
TA  - BMC Med
JT  - BMC medicine
JID - 101190723
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Catheter-Related Infections/prevention & control
MH  - Catheterization, Peripheral/*adverse effects/economics/*methods
MH  - Device Removal
MH  - Equipment Failure
MH  - Female
MH  - Humans
MH  - Infusions, Intravenous/*adverse effects/*methods
MH  - Male
MH  - Middle Aged
MH  - Phlebitis/prevention & control
MH  - Practice Guidelines as Topic
MH  - Time Factors
PMC - PMC2944158
EDAT- 2010/09/14 06:00
MHDA- 2011/02/17 06:00
CRDT- 2010/09/14 06:00
PHST- 2010/04/13 00:00 [received]
PHST- 2010/09/10 00:00 [accepted]
PHST- 2010/09/14 06:00 [entrez]
PHST- 2010/09/14 06:00 [pubmed]
PHST- 2011/02/17 06:00 [medline]
AID - 1741-7015-8-53 [pii]
AID - 10.1186/1741-7015-8-53 [doi]
PST - epublish
SO  - BMC Med. 2010 Sep 10;8:53. doi: 10.1186/1741-7015-8-53.


PMID- 20831763
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20211203
IS  - 1545-5300 (Electronic)
IS  - 0014-7370 (Linking)
VI  - 49
IP  - 3
DP  - 2010 Sep
TI  - Changing constructions of machismo for Latino men in therapy: "the devil never
      sleeps".
PG  - 309-29
LID - 10.1111/j.1545-5300.2010.01325.x [doi]
AB  - This paper presents current narratives about masculinity that question simplistic
      negative stereotypes of machismo for Latino heterosexual men. Various models of
      masculinity within Latino cultures are described using evidence from ethnographic
      studies, research data, and clinical observation. Therapeutic advantages of
      including positive cultural masculine traits such as respect and dignity are
      illustrated with an extensive case study. The case highlights contradictions in
      the coexistence of constructions of masculinity and traces progressive stages for
      transforming these constructions. In this strength-based approach, attention is
      directed to elements of cultural memory that reclaim a strong relational ethic
      present in the indigenous cultures. "Within the culture" definitions of
      masculinity contribute alternative constructions toward a more empowering
      cultural narrative for Latino men than the usual negative stereotypes.
CI  - 2010 (c) FPI, Inc.
FAU - Falicov, Celia Jaes
AU  - Falicov CJ
AD  - University of California San Diego Student-Run Free Clinic Project and
      Independent Practice, San Diego, CA, USA. cfalicov@ucsd.edu
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Fam Process
JT  - Family process
JID - 0400666
SB  - IM
MH  - Adaptation, Psychological
MH  - Adult
MH  - *Cultural Diversity
MH  - *Culture
MH  - Hispanic or Latino/*psychology
MH  - Humans
MH  - Male
MH  - *Masculinity
MH  - *Psychological Theory
MH  - Social Identification
MH  - *Social Perception
MH  - United States
EDAT- 2010/09/14 06:00
MHDA- 2011/01/07 06:00
CRDT- 2010/09/14 06:00
PHST- 2010/09/14 06:00 [entrez]
PHST- 2010/09/14 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
AID - 10.1111/j.1545-5300.2010.01325.x [doi]
PST - ppublish
SO  - Fam Process. 2010 Sep;49(3):309-29. doi: 10.1111/j.1545-5300.2010.01325.x.


PMID- 20831719
OWN - NLM
STAT- MEDLINE
DCOM- 20101028
LR  - 20211020
IS  - 1532-5415 (Electronic)
IS  - 0002-8614 (Linking)
VI  - 58
IP  - 10
DP  - 2010 Oct
TI  - How should we use age to ration health care? Lessons from the case of kidney
      transplantation.
PG  - 1980-6
LID - 10.1111/j.1532-5415.2010.03031.x [doi]
AB  - Competing visions for health reform in the United States and renewed interest in 
      health technology assessment (HTA) have led to fierce national debates about the 
      appropriateness of rationing. Because of a limited supply of organs, kidney
      transplantation has always required rationing and overt discussion of the ethics 
      that guide it, but the field of transplantation has also contended recently with 
      internal calls for a new rationing system. The aim of the Life Years from
      Transplantation (LYFT) proposal is to allocate kidneys to patients who obtain the
      greatest survival benefit from transplantation, which would lengthen the lives of
      kidney transplant recipients but restrict the ability of older Americans to
      obtain a transplant. The debate around the LYFT proposal reveals the ethical and 
      policy challenges of identifying which patients should receive a treatment based 
      on the results of cost-effectiveness and other HTA studies. This article argues
      that attempts to use HTA for healthcare rationing are likely to disadvantage
      older patients. Guiding principles to help ensure that resources such as kidneys 
      are justly allocated across the life span are proposed.
CI  - (c) 2010, Copyright the Authors. Journal compilation (c) 2010, The American
      Geriatrics Society.
FAU - Reese, Peter P
AU  - Reese PP
AD  - Renal Division, Department of Medicine, University of Pennsylvania, Philadelphia,
      Pennsylvania, USA. Peter.Reese@uphs.upenn.edu
FAU - Caplan, Arthur L
AU  - Caplan AL
FAU - Bloom, Roy D
AU  - Bloom RD
FAU - Abt, Peter L
AU  - Abt PL
FAU - Karlawish, Jason H
AU  - Karlawish JH
LA  - eng
GR  - K23 DK078688/DK/NIDDK NIH HHS/United States
GR  - K23 DK078688-04/DK/NIDDK NIH HHS/United States
GR  - K23-DK078688-01/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100909
PL  - United States
TA  - J Am Geriatr Soc
JT  - Journal of the American Geriatrics Society
JID - 7503062
SB  - IM
MH  - Aged
MH  - *Aging
MH  - Geriatric Assessment/*methods
MH  - Government Agencies
MH  - Health Care Rationing/*organization & administration
MH  - *Health Policy
MH  - Humans
MH  - Kidney Transplantation/*legislation & jurisprudence
MH  - United States
PMC - PMC4570233
MID - NIHMS294741
EDAT- 2010/09/14 06:00
MHDA- 2010/10/29 06:00
CRDT- 2010/09/14 06:00
PHST- 2010/09/14 06:00 [entrez]
PHST- 2010/09/14 06:00 [pubmed]
PHST- 2010/10/29 06:00 [medline]
AID - 10.1111/j.1532-5415.2010.03031.x [doi]
PST - ppublish
SO  - J Am Geriatr Soc. 2010 Oct;58(10):1980-6. doi: 10.1111/j.1532-5415.2010.03031.x. 
      Epub 2010 Sep 9.


PMID- 20831436
OWN - NLM
STAT- MEDLINE
DCOM- 20110204
LR  - 20220409
IS  - 1557-7740 (Electronic)
IS  - 1557-7740 (Linking)
VI  - 13
IP  - 10
DP  - 2010 Oct
TI  - The impact of neonatologists' religiosity and spirituality on health care
      delivery for high-risk neonates.
PG  - 1219-24
LID - 10.1089/jpm.2010.0049 [doi]
AB  - BACKGROUND: Ethical decision-making regarding life-sustaining therapies (LST) for
      high-risk neonates can be challenging for both neonatologists and parents.
      Parents depend on neonatologists to interpret complex information, identify
      critical opportunities for decision-making, and present options for care. How
      neonatologists' belief systems affect care delivery for critically ill newborns
      is unexplored. OBJECTIVE: To characterize the relationship between
      neonatologists' religiosity or spirituality and the provision of intensive care
      services for high-risk newborns. METHODS: Neonatologists practicing at an
      American Academy of Pediatrics Neonatal-Perinatal Training Program were surveyed 
      about their religious/spiritual beliefs, provision of LST for critically ill
      neonates, and communication with families. RESULTS: Two hundred ninety-eight
      neonatologists responded to the survey; 66.4% consider themselves very or
      moderately spiritual, 40.8% very or moderately religious. In response to a
      hypothetical prenatal consultation for a fetus at 23 1/7 weeks gestation, 96.3%
      agreed that the physician has a moral obligation to present all options to
      parents, including the provision of comfort care. More than 95% had no objection 
      to withholding or withdrawing LST, with religion playing almost no part in these 
      decisions. 38% of participants reported no objection to resuscitating an infant
      with trisomy 13 or 18; 40% of these neonatologists considered themselves
      very/moderately religious, 60% slightly/not at all religious. Eighty-nine
      neonatologists reported that their religious beliefs influence their medical
      practice. These physicians had similar responses as those not influenced by
      religion. CONCLUSION: For the majority of neonatologists participating in this
      study, differences in critical care practice cannot be attributed to personal
      religious or spiritual views.
FAU - Donohue, Pamela K
AU  - Donohue PK
AD  - Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland
      21287, USA. pdonohu2@jhmi.edu
FAU - Boss, Renee D
AU  - Boss RD
FAU - Aucott, Susan W
AU  - Aucott SW
FAU - Keene, Elizabeth A
AU  - Keene EA
FAU - Teague, Paula
AU  - Teague P
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Palliat Med
JT  - Journal of palliative medicine
JID - 9808462
SB  - IM
MH  - Analysis of Variance
MH  - *Attitude of Health Personnel
MH  - Critical Illness/*psychology/*therapy
MH  - Decision Making/*ethics
MH  - Delivery of Health Care/*ethics
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Logistic Models
MH  - Male
MH  - Morals
MH  - *Neonatology
MH  - Practice Patterns, Physicians'/ethics/statistics & numerical data
MH  - *Religion
MH  - *Spirituality
MH  - Surveys and Questionnaires
EDAT- 2010/09/14 06:00
MHDA- 2011/02/05 06:00
CRDT- 2010/09/14 06:00
PHST- 2010/09/14 06:00 [entrez]
PHST- 2010/09/14 06:00 [pubmed]
PHST- 2011/02/05 06:00 [medline]
AID - 10.1089/jpm.2010.0049 [doi]
PST - ppublish
SO  - J Palliat Med. 2010 Oct;13(10):1219-24. doi: 10.1089/jpm.2010.0049.


PMID- 20831424
OWN - NLM
STAT- MEDLINE
DCOM- 20101109
LR  - 20100913
IS  - 1556-2646 (Print)
IS  - 1556-2646 (Linking)
VI  - 5
IP  - 3
DP  - 2010 Sep
TI  - Educational advantage.
PG  - 99-101
LID - 10.1525/jer.2010.5.3.99 [doi]
AB  - This issue examines topics relevant to the effects of communicating disclosure
      risk to participants in survey research, managing genetic data, paying research
      participants, and evaluating institutional research ethics. Educational
      activities are presented that will enable readers to consolidate their knowledge 
      and understanding of these topics.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Disclosure
MH  - Ethics, Institutional
MH  - *Ethics, Research
MH  - Genetic Research/ethics
MH  - Health Surveys
MH  - Humans
MH  - Informed Consent/ethics
EDAT- 2010/09/14 06:00
MHDA- 2010/11/10 06:00
CRDT- 2010/09/14 06:00
PHST- 2010/09/14 06:00 [entrez]
PHST- 2010/09/14 06:00 [pubmed]
PHST- 2010/11/10 06:00 [medline]
AID - 10.1525/jer.2010.5.3.99 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2010 Sep;5(3):99-101. doi: 10.1525/jer.2010.5.3.99.


PMID- 20831423
OWN - NLM
STAT- MEDLINE
DCOM- 20101109
LR  - 20220330
IS  - 1556-2646 (Print)
IS  - 1556-2646 (Linking)
VI  - 5
IP  - 3
DP  - 2010 Sep
TI  - Development of an accessible self-assessment tool for research ethics committees 
      in developing countries.
PG  - 85-96; quiz 97-8
LID - 10.1525/jer.2010.5.3.85 [doi]
AB  - In response to increased research being performed in developing countries, many
      research ethics committees (RECs) have been established, but the quality of their
      ethics review systems remains unknown. Evaluating the performance of an REC
      remains a challenging task. Absent an accreditation process, a self-assessment
      mechanism would provide RECs a way to review their policies and processes against
      recognized international standards. We describe a self-assessment tool that was
      developed and reviewed by REC members and researchers from the Middle East. This 
      tool reflects pragmatic aspects of human subjects protection, is based on
      international standards, is straightforward in its completion, and its items are 
      relevant to the administrative processes that exist in many RECs in the
      developing world.
FAU - Sleem, Hany
AU  - Sleem H
AD  - National Hepatology and Tropical Medicine Research Institute, Egypt.
FAU - Abdelhai, Rehab Abdelhai Ahmed
AU  - Abdelhai RA
FAU - Al-Abdallat, Imad
AU  - Al-Abdallat I
FAU - Al-Naif, Mohammed
AU  - Al-Naif M
FAU - Gabr, Hala Mansour
AU  - Gabr HM
FAU - Kehil, Et-Taher
AU  - Kehil ET
FAU - Sadiq, Bakr Bin
AU  - Sadiq BB
FAU - Yousri, Reham
AU  - Yousri R
FAU - Elsayed, Dyaeldin
AU  - Elsayed D
FAU - Sulaiman, Suad
AU  - Sulaiman S
FAU - Silverman, Henry
AU  - Silverman H
LA  - eng
GR  - R25 TW007090/TW/FIC NIH HHS/United States
GR  - R25 TW007090-01/TW/FIC NIH HHS/United States
GR  - R25TW 007090/TW/FIC NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - *Certification
MH  - *Developing Countries
MH  - Educational Measurement/*methods
MH  - *Ethics Committees, Research
MH  - Ethics, Research/*education
MH  - Humans
MH  - Middle East
MH  - Professional Autonomy
PMC - PMC3151168
MID - NIHMS312835
EDAT- 2010/09/14 06:00
MHDA- 2010/11/10 06:00
CRDT- 2010/09/14 06:00
PHST- 2010/09/14 06:00 [entrez]
PHST- 2010/09/14 06:00 [pubmed]
PHST- 2010/11/10 06:00 [medline]
AID - 10.1525/jer.2010.5.3.85 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2010 Sep;5(3):85-96; quiz 97-8. doi:
      10.1525/jer.2010.5.3.85.


PMID- 20831420
OWN - NLM
STAT- MEDLINE
DCOM- 20101109
LR  - 20220317
IS  - 1556-2646 (Print)
IS  - 1556-2646 (Linking)
VI  - 5
IP  - 3
DP  - 2010 Sep
TI  - Why do we pay? A national survey of investigators and IRB chairpersons.
PG  - 43-56
LID - 10.1525/jer.2010.5.3.43 [doi]
AB  - The principle that payment to participants should not be undue or coercive is the
      consensus of international and national guidelines and ethical debates; however, 
      what this means in practice is unclear. This study determined the attitudes and
      practices of IRB chairpersons and investigators regarding participant payment.
      One thousand six hundred investigators and 1900 IRB chairpersons received an
      invitation to participate in a web-based survey. Four hundred and fifty-five
      investigators (28.3%) and 395 IRB chairpersons (18.6%) responded. The survey was 
      designed to gather considerations that govern payment determination and practical
      application of these considerations in hypothetical case studies. The survey
      asked best answer, multiple choice, and open text questions. Short hypothetical
      case scenarios where presented, and participants were asked to rate factors in
      the study that might impact payment and then determine their recommended payment.
      A predictive model was developed for each case to determine factors which
      affected payment. Although compensation was the primary reason given to justify
      payment by both investigators and IRB chairpersons, the cases suggested that, in 
      practice, payment is often guided by incentive, as shown by the impact of
      anticipated difficulty recruiting, inconvenience, and risk in determining
      payment. Payment models varied by type of study. Ranges for recommended payments 
      by both groups for different types of procedures and studies are presented.
FAU - Ripley, Elizabeth
AU  - Ripley E
AD  - Division of nephrology, Virginia Commonwealth University, USA.
      eripley@mcvh-vcu.edu
FAU - Macrina, Francis
AU  - Macrina F
FAU - Markowitz, Monika
AU  - Markowitz M
FAU - Gennings, Chris
AU  - Gennings C
LA  - eng
GR  - R21 NR010399/NR/NINR NIH HHS/United States
GR  - R21 NR010399-02/NR/NINR NIH HHS/United States
GR  - 5R21NR010399-02/NR/NINR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - *Attitude
MH  - Data Collection
MH  - Ethics Committees, Research
MH  - *Fees and Charges
MH  - Female
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Patient Selection/*ethics
MH  - Research Subjects/*economics
MH  - United States
PMC - PMC3168552
MID - NIHMS312831
EDAT- 2010/09/14 06:00
MHDA- 2010/11/10 06:00
CRDT- 2010/09/14 06:00
PHST- 2010/09/14 06:00 [entrez]
PHST- 2010/09/14 06:00 [pubmed]
PHST- 2010/11/10 06:00 [medline]
AID - 10.1525/jer.2010.5.3.43 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2010 Sep;5(3):43-56. doi: 10.1525/jer.2010.5.3.43.


PMID- 20831018
OWN - NLM
STAT- MEDLINE
DCOM- 20101102
LR  - 20161125
IS  - 2306-4102 (Print)
IS  - 2306-4102 (Linking)
VI  - 24
IP  - 2
DP  - 2010 Mar-Apr
TI  - [Fracture dislocation of the thoracolumbar spine in pregnant patient: diagnostic 
      by image and treatment].
PG  - 100-7
AB  - BACKGROUND: Fracture dislocations of the thoracolumbar spine are, to a great
      extent, associated with neurologic deficit and instability, so a large percentage
      of them require surgical treatment. Being pregnant does not rule out the
      possibility of having this type of lesions. There are only a few bibliographic
      references concerning these cases and medical and treatment ignorance about them 
      is frequent. OBJECTIVE: Present a review of concepts and specifications for the
      correct and safe imaging diagnosis as well as considerations on the surgical
      treatment of patients with traumatic thoracolumbar spine lesions who are
      pregnant. MATERIAL AND METHODS: A bibliographic review will be presented together
      with a clinical case of the CALRM, a 31-year-old female with a fracture
      dislocation at T12-L1, ASIA E, who at the time of the lesion was nine weeks
      pregnant, and was managed with a multidisciplinary approach that included the
      following services: Obstetrics and Gynecology, Pediatrics, Anesthesiology,
      Radiology and Imaging, Legal Medicine, Spine Surgery, and the hospital's Ethics
      Committee. RESULTS: The diagnosis and characteristics of the lesion were assessed
      properly with standard X-rays and the support of MRI. The patient underwent
      posterior stabilization with a transpedicular system while she was pregnant, and 
      bone graft harvesting and application with an anterior approach after the
      pregnancy, without any complications. CONCLUSIONS: The correct understanding of
      the nature of ionizing radiation allows using an acceptable dose range according 
      to the study performed and the patient's gestational age. Any patient with a
      fracture dislocation of the thoracolumbar spine who can tolerate the procedure
      should be stabilized. Moreover, the fetal risks of the surgical and anesthetic
      procedure may be avoided with an appropriate selection of the technique and the
      anesthetic agents, as well as with continuous maternal and fetal monitoring.
FAU - Martinez-Padilla, Luis Alberto
AU  - Martinez-Padilla LA
AD  - Hospital General La Villa, Secretaria de Salud del Distrito Federal.
      luismtz_ort@yahoo.com.mx
FAU - Santana-Reyna, Miguel Angel
AU  - Santana-Reyna MA
FAU - Diaz-Ruiz, Omar Simitrio
AU  - Diaz-Ruiz OS
FAU - Silva-Escalante, David
AU  - Silva-Escalante D
FAU - Dufoo-Olvera, Manuel
AU  - Dufoo-Olvera M
FAU - Garcia-Lopez, Oscar Felipe
AU  - Garcia-Lopez OF
FAU - Lopez-Palacios, Jose de Jesus
AU  - Lopez-Palacios Jde J
FAU - Carranco-Toledo, Gabriel Alfonso
AU  - Carranco-Toledo GA
FAU - Aburto-Trejo, Jose Antonio
AU  - Aburto-Trejo JA
LA  - spa
PT  - Case Reports
PT  - Journal Article
PT  - Review
TT  - Fractura-luxacion de columna toracolumbar en paciente gestante: diagnostico por
      imagen y tratamiento.
PL  - Mexico
TA  - Acta Ortop Mex
JT  - Acta ortopedica mexicana
JID - 101190312
SB  - IM
MH  - Adult
MH  - Diagnostic Imaging
MH  - Female
MH  - Humans
MH  - *Joint Dislocations/diagnosis/therapy
MH  - Lumbar Vertebrae/*injuries
MH  - Pregnancy
MH  - *Pregnancy Complications/diagnosis/therapy
MH  - *Spinal Fractures/diagnosis/therapy
MH  - Thoracic Vertebrae/*injuries
EDAT- 2010/09/14 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/09/14 06:00
PHST- 2010/09/14 06:00 [entrez]
PHST- 2010/09/14 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
PST - ppublish
SO  - Acta Ortop Mex. 2010 Mar-Apr;24(2):100-7.


PMID- 20829856
OWN - NLM
STAT- MEDLINE
DCOM- 20101223
LR  - 20191210
IS  - 1476-5373 (Electronic)
IS  - 0007-0610 (Linking)
VI  - 209
IP  - 5
DP  - 2010 Sep 11
TI  - Risk management in clinical practice. Part 5. Ethical considerations for dental
      enhancement procedures.
PG  - 207-14
LID - 10.1038/sj.bdj.2010.769 [doi]
AB  - After the demise of the Industrial Age, we currently live in an 'Information Age'
      fuelled mainly by the Internet, with an ever-increasing medically and dentally
      literate population. The media has played its role by reporting scientific
      advances, as well as securitising medical and dental practices. Reality
      television such as 'Extreme makeovers' has also raised public awareness of body
      enhancements, with a greater number of people seeking such procedures. To satiate
      this growing demand, the dental industry has flourished by introducing novel
      cosmetic products such as bleaching kits, tooth coloured filling materials and a 
      variety of dental ceramics. In addition, one only has to browse through a dental 
      journal to notice innumerable courses and lectures on techniques for providing
      cosmetic dentistry. The incessant public interest, combined with unrelenting
      marketing by companies is gradually shifting the balance of dental care from a
      healing to an enhancement profession. The purpose of this article is to endeavour
      to answer questions such as, What is aesthetic or cosmetic dentistry? Why do
      patients seek cosmetic dentistry? Are enhancement procedures a part of dental
      practice? What, if any, ethical guidelines and constraints apply to elective
      enhancement procedures? What is the role of the dentist in providing or
      encouraging this type of 'therapy'? What treatment modalities are available for
      aesthetic dental treatment?
FAU - Ahmad, I
AU  - Ahmad I
AD  - The Ridgeway Dental Surgery, 173 The Ridgeway, North Harrow, Middlesex, HA2 7DF. 
      iahmadbds@aol.com
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br Dent J
JT  - British dental journal
JID - 7513219
RN  - 0 (Dental Implants)
SB  - IM
MH  - Attitude to Health
MH  - Conflict, Psychological
MH  - Dental Care/*ethics
MH  - Dental Implants
MH  - Dental Records
MH  - Dental Restoration, Permanent
MH  - Esthetics
MH  - *Esthetics, Dental
MH  - *Ethics, Dental
MH  - Health Services Needs and Demand
MH  - Humans
MH  - Informed Consent
MH  - Marketing of Health Services/ethics
MH  - Orthodontics, Corrective
MH  - Paternalism/ethics
MH  - Patient Acceptance of Health Care
MH  - Patient Care Planning
MH  - Personal Autonomy
MH  - Personality
MH  - Practice Management, Dental/ethics
MH  - Professional Competence
MH  - Professional Practice/ethics
MH  - Risk Assessment
MH  - Risk Management/*ethics
MH  - Tooth Bleaching
EDAT- 2010/09/11 06:00
MHDA- 2010/12/25 06:00
CRDT- 2010/09/11 06:00
PHST- 2009/10/20 00:00 [accepted]
PHST- 2010/09/11 06:00 [entrez]
PHST- 2010/09/11 06:00 [pubmed]
PHST- 2010/12/25 06:00 [medline]
AID - sj.bdj.2010.769 [pii]
AID - 10.1038/sj.bdj.2010.769 [doi]
PST - ppublish
SO  - Br Dent J. 2010 Sep 11;209(5):207-14. doi: 10.1038/sj.bdj.2010.769.


PMID- 20829723
OWN - NLM
STAT- MEDLINE
DCOM- 20101115
LR  - 20211201
IS  - 1537-1948 (Electronic)
IS  - 0025-7079 (Linking)
VI  - 48
IP  - 11
DP  - 2010 Nov
TI  - How does routine disclosure of medical error affect patients' propensity to sue
      and their assessment of provider quality? Evidence from survey data.
PG  - 955-61
LID - 10.1097/MLR.0b013e3181eaf84d [doi]
AB  - BACKGROUND: Although strongly favored by patients and ethically imperative for
      providers, the disclosure of medical errors to patients remains rare because
      providers fear that it will trigger lawsuits and jeopardize their reputation. To 
      date little is known how patients might respond to their providers' disclosure of
      a medical error even when paired with an offer of remediation. RESEARCH DESIGN: A
      representative sample of Illinois residents was surveyed in 2008 about their
      knowledge about medical errors, their confidence that their providers would
      disclose medical errors to them, and their propensity to sue and recommend
      providers that disclose medical errors and offer to remedy them. We report the
      response patterns to these questions. As robustness checks, we also estimate the 
      covariate-adjusted distributions and test the associations among these dimensions
      of medical-error disclosure. RESULTS: Of the 1018 respondents, 27% would sue and 
      38% would recommend the hospital after medical error disclosure with an
      accompanying offer of remediation. Compared with the least confident respondents,
      those who were more confident in their providers' commitment to disclose were not
      likely to sue but significantly and substantially more likely to recommend their 
      provider. CONCLUSIONS: Patients who are confident in their providers' commitment 
      to disclose medical errors are not more litigious and far more forgiving than
      patients who have no faith in their providers' commitment to disclose.
FAU - Helmchen, Lorens A
AU  - Helmchen LA
AD  - School of Public Health, Division of Health Policy and Administration, University
      of Illinois, Chicago, IL, USA. helmchen@uic.edu
FAU - Richards, Michael R
AU  - Richards MR
FAU - McDonald, Timothy B
AU  - McDonald TB
LA  - eng
GR  - T32 AG000186/AG/NIA NIH HHS/United States
GR  - T32 AG000186-21/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Med Care
JT  - Medical care
JID - 0230027
SB  - IM
MH  - Adult
MH  - Aged
MH  - Attitude of Health Personnel
MH  - Confidentiality
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Illinois/epidemiology
MH  - Male
MH  - Malpractice/legislation & jurisprudence/*statistics & numerical data
MH  - Medical Errors/prevention & control/*statistics & numerical data
MH  - Middle Aged
MH  - Patient Compliance/psychology/*statistics & numerical data
MH  - *Physician-Patient Relations
MH  - Population Surveillance
MH  - Socioeconomic Factors
MH  - Surveys and Questionnaires
MH  - *Trust
MH  - *Truth Disclosure
MH  - Young Adult
EDAT- 2010/09/11 06:00
MHDA- 2010/11/16 06:00
CRDT- 2010/09/11 06:00
PHST- 2010/09/11 06:00 [entrez]
PHST- 2010/09/11 06:00 [pubmed]
PHST- 2010/11/16 06:00 [medline]
AID - 10.1097/MLR.0b013e3181eaf84d [doi]
PST - ppublish
SO  - Med Care. 2010 Nov;48(11):955-61. doi: 10.1097/MLR.0b013e3181eaf84d.


PMID- 20829581
OWN - NLM
STAT- MEDLINE
DCOM- 20110407
LR  - 20211020
IS  - 1662-8063 (Electronic)
IS  - 1662-4246 (Linking)
VI  - 13
IP  - 7-8
DP  - 2010
TI  - Preferences regarding genetic research results: comparing veterans and
      nonveterans responses.
PG  - 431-9
LID - 10.1159/000317099 [doi]
AB  - OBJECTIVE: Communicating genetic research results to participants presents
      ethical challenges. Our objectives were to examine participants' preferences in
      receiving future genetic research results and to compare preferences reported by 
      veteran and nonveterans participants. METHODS: Secondary analysis was performed
      on data collected in 2000-2004 from 1,575 consent forms signed by
      Mexican-American participants enrolled in 2 genetic family studies (GFS) in San
      Antonio: The Family Investigation of Nephropathy and Diabetes (FIND) and the
      Extended FIND (EFIND). The consent forms for these studies contained
      multiple-choice questions to examine participants' preferences about receiving
      their (1) clinical lab results and (2) future genetic research results. The FIND 
      and EFIND databases had information on subjects' demographic characteristics and 
      some selected clinical variables. We identified veterans using the Veterans
      Health Administration's (VHA's) centralized data repository. We compared
      veterans' and nonveterans' preferences using Student's t test for continuous
      variables and chi(2) test for discrete variables. A logistic regression analyzed 
      subjects' preference for receiving their research results, controlling for other 
      socio-demographic and clinical variables. RESULTS: The sample included 275 (18%) 
      veterans and 1,247 (82%) nonveterans. Our results indicated a strong desire among
      the majority of participants 1,445 (95%) in getting their clinical lab research
      results. Likewise, 93% expressed interest in being informed about their future
      genetic results. There was no significant difference in veterans' and
      nonveterans' preference to disclosure of the research results (chi(2) test; p >
      0.05). Regression analysis showed no significant relationship (p = 0.449) between
      the outcome (receiving research results) and veterans' responses after
      controlling for demographics and educational levels. CONCLUSION: Participants
      believed they would prefer receiving their genetic research results. Veterans are
      similar to nonveterans in their preferences. Offering genetic research results to
      participants should be based on well defined and structured plans to enhance
      interpretation of genetic data.
CI  - Copyright (c) 2010 S. Karger AG, Basel.
FAU - Arar, N
AU  - Arar N
AD  - Division of Nephrology, Department of Medicine, University of Texas Health
      Science Center at San Antonio, Audie L. Murphy Memorial Veterans Hospital, San
      Antonio, TX 78229-3900, USA. ararn@uthscsa.edu
FAU - Seo, J
AU  - Seo J
FAU - Lee, S
AU  - Lee S
FAU - Abboud, H E
AU  - Abboud HE
FAU - Copeland, L A
AU  - Copeland LA
FAU - Noel, P
AU  - Noel P
FAU - Parchman, M
AU  - Parchman M
LA  - eng
GR  - P50 DK061597/DK/NIDDK NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20100909
PL  - Switzerland
TA  - Public Health Genomics
JT  - Public health genomics
JID - 101474167
SB  - IM
MH  - Diabetes Mellitus/*genetics
MH  - Diabetic Nephropathies/*genetics
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genetic Research/*ethics
MH  - Humans
MH  - Male
MH  - Mexican Americans
MH  - Middle Aged
MH  - *Research Subjects
MH  - Truth Disclosure/*ethics
MH  - United States
MH  - Veterans/*statistics & numerical data
MH  - Veterans Health
PMC - PMC3025894
EDAT- 2010/09/11 06:00
MHDA- 2011/04/08 06:00
CRDT- 2010/09/11 06:00
PHST- 2009/11/25 00:00 [received]
PHST- 2010/06/16 00:00 [accepted]
PHST- 2010/09/11 06:00 [entrez]
PHST- 2010/09/11 06:00 [pubmed]
PHST- 2011/04/08 06:00 [medline]
AID - 000317099 [pii]
AID - 10.1159/000317099 [doi]
PST - ppublish
SO  - Public Health Genomics. 2010;13(7-8):431-9. doi: 10.1159/000317099. Epub 2010 Sep
      9.


PMID- 20829533
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20151119
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 257
IP  - 2
DP  - 2010 Nov
TI  - MR imaging depicts oxidative stress induced by methemoglobin.
PG  - 470-6
LID - 10.1148/radiol.10100416 [doi]
AB  - PURPOSE: To correlate the effect of red blood cell hemoglobin on signal
      generation during magnetic resonance (MR) imaging and local oxidation of
      low-density lipoprotein (LDL). MATERIALS AND METHODS: Informed consent was
      obtained from all volunteers participating in this study, which was approved by
      the research ethics board. T1 relaxometry of blood samples from six volunteers
      was performed. Lipid peroxidation was assayed by using thiobarbituric acid
      reactive species (TBARS) and fluorescence quenching of cis-parinaric acid.
      Two-tailed Student t tests were used to detect differences between means. A
      Pearson correlation coefficient was calculated to determine the linearity of the 
      data. RESULTS: Lipid oxidation was significantly enhanced after addition of
      blood, according to results of the TBARS assay; greater oxidation occurred with
      ferric than with ferrous blood. The cis-parinaric acid assay demonstrated
      increased oxidative stress caused by extracellular as compared with intracellular
      ferric hemoglobin. MR imaging measures showed a T1 relaxivity that was 10 times
      higher for ferric than for ferrous forms of hemoglobin. CONCLUSION: Extracellular
      ferric hemoglobin is significantly more pro-oxidant and has higher T1 relaxivity 
      than its ferrous counterparts. These results support the hypothesis that ferric
      methemoglobin-generated T1 high signal intensity reflects a pro-oxidant
      environment that, in the setting of vessel wall disease, might be proatherogenic.
CI  - (c) RSNA, 2010.
FAU - Leung, General
AU  - Leung G
AD  - Department of Medical Biophysics, Sunnybrook Health Sciences Centre, 2075 Bayview
      Avenue-AG40A Magnetic Resonance, Toronto, ON, Canada M4N 3M5.
      general.leung@sunnybrook.ca
FAU - Moody, Alan R
AU  - Moody AR
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100909
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Fatty Acids, Unsaturated)
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 9008-37-1 (Methemoglobin)
RN  - PK8M3ENX8C (parinaric acid)
SB  - IM
MH  - Fatty Acids, Unsaturated/metabolism
MH  - Humans
MH  - Lipid Peroxidation
MH  - Lipoproteins, LDL/metabolism
MH  - Magnetic Resonance Imaging/*methods
MH  - Methemoglobin/*pharmacology
MH  - Oxidation-Reduction
MH  - *Oxidative Stress
MH  - Thiobarbituric Acid Reactive Substances/metabolism
EDAT- 2010/09/11 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/09/11 06:00
PHST- 2010/09/11 06:00 [entrez]
PHST- 2010/09/11 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - radiol.10100416 [pii]
AID - 10.1148/radiol.10100416 [doi]
PST - ppublish
SO  - Radiology. 2010 Nov;257(2):470-6. doi: 10.1148/radiol.10100416. Epub 2010 Sep 9.


PMID- 20829389
OWN - NLM
STAT- MEDLINE
DCOM- 20110527
LR  - 20110124
IS  - 1569-9285 (Electronic)
IS  - 1569-9285 (Linking)
VI  - 12
IP  - 2
DP  - 2011 Feb
TI  - How good patient blood management leads to excellent outcomes in Jehovah's
      witness patients undergoing cardiac surgery.
PG  - 183-8
LID - 10.1510/icvts.2010.242552 [doi]
AB  - OBJECTIVES: The refusal of blood products makes open-heart surgery in Jehovah's
      witnesses (JW) an ethical challenge. We demonstrate how patient blood management 
      strategies lead to excellent surgical outcomes. METHODS: From 2003 to 2008, 16 JW
      underwent cardiac surgery at our institution. Only senior surgeons performed
      coronary revascularization (n=6), valve (n=6), combined (n=1) and aortic surgery 
      (n=3) of which two patients presented with acute type-A dissection. Off-pump
      surgery remained the method of choice for patients requiring a bypass procedure
      (n=5). Preoperative hematocrit (Hk) and hemoglobin (Hb) were 42.8+/-4.7% and
      14.5+/-2 g/dl. In three patients with an Hb<12 g/dl, preoperative hematological
      stimulating treatment was implemented. RESULTS: All patients survived, no major
      complications occurred and no blood transfusion was administered. The Cell
      Saver(R) system (transfused volume: 474+/-101 ml) and synthetic plasma
      substitutes [Ringer's Lactate: 873+/-367 ml and hydroxyethyl starch (HES) 6%:
      700+/-388 ml] were used routinely as well as hemostaticas, such as bone wax, and 
      fibrin glue. The decrease of Hk and Hb appeared to be the lowest after off-pump
      surgery when compared to all other procedures requiring cardiopulmonary bypass
      (CPB) (25+/-9% vs. 33+/-6%; P=0.01 and 22+/-9% vs. 31+/-6%; P=0.04). Similarly,
      the decrease of platelets was significantly lower (20+/-12% vs. 43+/-14%;
      P=0.01). In the follow-up period (52+/-34 months), one patient died due to a
      non-cardiac reason, whereas all others were alive, in good clinical condition and
      did not have major adverse cardiac events (MACE) or recurrent symptoms requiring 
      re-intervention. CONCLUSION: Patient blood management leads to excellent short-
      and long-term outcomes in JW. Combined efforts in regard to preoperative
      hematological parameter optimization, effective volume management and meticulous 
      surgical techniques make this possible but raise the cautionary note why this is 
      only possible in JW patients.
FAU - Emmert, Maximilian Y
AU  - Emmert MY
AD  - Clinic for Cardiovascular Surgery, Institute of Anaesthesiology, University
      Hospital Zurich, Ramistrasse 100, 8091 Zurich, Switzerland.
      maximilian.emmert@usz.ch
FAU - Salzberg, Sacha P
AU  - Salzberg SP
FAU - Theusinger, Oliver M
AU  - Theusinger OM
FAU - Felix, Christian
AU  - Felix C
FAU - Plass, Andre
AU  - Plass A
FAU - Hoerstrup, Simon P
AU  - Hoerstrup SP
FAU - Falk, Volkmar
AU  - Falk V
FAU - Gruenenfelder, Juerg
AU  - Gruenenfelder J
LA  - eng
PT  - Journal Article
DEP - 20100909
PL  - England
TA  - Interact Cardiovasc Thorac Surg
JT  - Interactive cardiovascular and thoracic surgery
JID - 101158399
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Blood Loss, Surgical/prevention & control
MH  - Blood Transfusion/ethics
MH  - Cardiac Surgical Procedures/*methods/mortality
MH  - Databases, Factual
MH  - Female
MH  - Fluid Therapy/*methods
MH  - Follow-Up Studies
MH  - Hemodynamics/*physiology
MH  - Humans
MH  - *Jehovah's Witnesses
MH  - Male
MH  - Middle Aged
MH  - Monitoring, Intraoperative/methods
MH  - Preoperative Care/methods
MH  - *Religion and Medicine
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Statistics, Nonparametric
MH  - Survival Analysis
MH  - Treatment Outcome
MH  - Treatment Refusal
EDAT- 2010/09/11 06:00
MHDA- 2011/05/28 06:00
CRDT- 2010/09/11 06:00
PHST- 2010/09/11 06:00 [entrez]
PHST- 2010/09/11 06:00 [pubmed]
PHST- 2011/05/28 06:00 [medline]
AID - icvts.2010.242552 [pii]
AID - 10.1510/icvts.2010.242552 [doi]
PST - ppublish
SO  - Interact Cardiovasc Thorac Surg. 2011 Feb;12(2):183-8. doi:
      10.1510/icvts.2010.242552. Epub 2010 Sep 9.


PMID- 20829262
OWN - NLM
STAT- MEDLINE
DCOM- 20110111
LR  - 20161020
IS  - 1527-330X (Electronic)
IS  - 1090-820X (Linking)
VI  - 30
IP  - 4
DP  - 2010 Jul-Aug
TI  - Ethical issues in aesthetic research.
PG  - 630-1
LID - 10.1177/1090820X10380713 [doi]
FAU - Larson, David L
AU  - Larson DL
LA  - eng
PT  - Editorial
PL  - England
TA  - Aesthet Surg J
JT  - Aesthetic surgery journal
JID - 9707469
SB  - IM
MH  - Biomedical Research/*ethics
MH  - *Esthetics
MH  - Humans
MH  - Informed Consent/ethics
MH  - Patient Selection/ethics
MH  - Research Design
MH  - Surgery, Plastic/*ethics
EDAT- 2010/09/11 06:00
MHDA- 2011/01/12 06:00
CRDT- 2010/09/11 06:00
PHST- 2010/09/11 06:00 [entrez]
PHST- 2010/09/11 06:00 [pubmed]
PHST- 2011/01/12 06:00 [medline]
AID - 30/4/630 [pii]
AID - 10.1177/1090820X10380713 [doi]
PST - ppublish
SO  - Aesthet Surg J. 2010 Jul-Aug;30(4):630-1. doi: 10.1177/1090820X10380713.


PMID- 20829060
OWN - NLM
STAT- MEDLINE
DCOM- 20111213
LR  - 20191210
IS  - 1036-7314 (Print)
IS  - 1036-7314 (Linking)
VI  - 24
IP  - 3
DP  - 2011 Aug
TI  - The provision of patient personal hygiene in the intensive care unit: a
      descriptive exploratory study of bed-bathing practice.
PG  - 198-209
LID - 10.1016/j.aucc.2010.08.001 [doi]
AB  - BACKGROUND/OBJECTIVES: The provision of the patient bed-bath is a fundamental
      nursing care activity yet few quantitative data and no qualitative data are
      available on registered nurses' (RNs) clinical practice in this domain in the
      intensive care unit (ICU). The aim of this study was to describe ICU RNs current 
      practice with respect to the timing, frequency and duration of the patient
      bed-bath and the cleansing and emollient agents used. METHODS: The study utilised
      a two-phase sequential explanatory mixed method design. Phase one used a
      questionnaire to survey RNs and phase two employed semi-structured focus group
      (FG) interviews with RNs. Data was collected over 28 days across four Australian 
      metropolitan ICUs. Ethical approval was granted from the relevant hospital and
      university human research ethics committees. RNs were asked to complete a
      questionnaire following each episode of care (i.e. bed-bath) and then to attend
      one of three FG interviews: RNs with less than 2 years ICU experience; RNs with
      2-5 years ICU experience; and RNs with greater than 5 years ICU experience.
      RESULTS: During the 28-day study period the four ICUs had 77.25 beds open. In
      phase one a total of 539 questionnaires were returned, representing 30.5% of
      episodes of patient bed-baths (based on 1767 bed occupancy and one bed-bath per
      patient per day). In 349 bed-bath episodes 54.7% patients were mechanically
      ventilated. The bed-bath was given between 02.00 and 06.00h in 161 episodes
      (30%), took 15-30min to complete (n=195, 36.2%) and was completed within the last
      8h in 304 episodes (56.8%). Cleansing agents used were predominantly pH balanced 
      soap or liquid soap and water (n=379, 71%) in comparison to chlorhexidine
      impregnated sponges/cloths (n=86, 16.1%) or other agents such as pre-packaged
      washcloths (n=65, 12.2%). In 347 episodes (64.4%) emollients were not applied
      after the bed-bath. In phase two 12 FGs were conducted (three FGs at each ICU)
      with a total of 42 RN participants. Thematic analysis of FG transcripts across
      the three levels of RN ICU experience highlighted a transition of patient hygiene
      practice philosophy from shades of grey - falling in line for inexperienced
      clinicians to experienced clinicians concrete beliefs about patient bed-bath
      needs. CONCLUSIONS: This study identified variation in process and products used 
      in patient hygiene practices in four ICUs. Further study to improve patient
      outcomes is required to determine the appropriate timing of patient hygiene
      activities and cleansing agents used to improve skin integrity.
CI  - Copyright (c) 2010 Australian College of Critical Care Nurses Ltd. Published by
      Elsevier Ltd. All rights reserved.
FAU - Coyer, Fiona M
AU  - Coyer FM
AD  - School of Nursing and Midwifery, Queensland University of Technology, Victoria
      Park Road, Kelvin Grove, QLD 4059, Australia. f.coyer@qut.edu.au
FAU - O'Sullivan, Judy
AU  - O'Sullivan J
FAU - Cadman, Nicola
AU  - Cadman N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100915
PL  - Australia
TA  - Aust Crit Care
JT  - Australian critical care : official journal of the Confederation of Australian
      Critical Care Nurses
JID - 9207852
RN  - 0 (Emollients)
MH  - Baths/*nursing/statistics & numerical data
MH  - Emollients/therapeutic use
MH  - Female
MH  - Focus Groups
MH  - Health Care Surveys
MH  - Health Services Research
MH  - Humans
MH  - *Hygiene/standards
MH  - Intensive Care Units/organization & administration/*standards
MH  - *Nurse's Role
MH  - Nursing Care/organization & administration/*standards
MH  - Outcome and Process Assessment, Health Care
EDAT- 2010/09/11 06:00
MHDA- 2011/12/14 06:00
CRDT- 2010/09/11 06:00
PHST- 2009/08/25 00:00 [received]
PHST- 2010/07/07 00:00 [revised]
PHST- 2010/08/03 00:00 [accepted]
PHST- 2010/09/11 06:00 [entrez]
PHST- 2010/09/11 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - S1036-7314(10)00121-9 [pii]
AID - 10.1016/j.aucc.2010.08.001 [doi]
PST - ppublish
SO  - Aust Crit Care. 2011 Aug;24(3):198-209. doi: 10.1016/j.aucc.2010.08.001. Epub
      2010 Sep 15.


PMID- 20828520
OWN - NLM
STAT- MEDLINE
DCOM- 20110201
LR  - 20151119
IS  - 1916-0216 (Electronic)
IS  - 1916-0208 (Linking)
VI  - 39
IP  - 5
DP  - 2010 Oct
TI  - Free tissue transfer flap reconstruction of parotidectomy defects: outcomes
      analysis and the utility of three-dimensional laser surface scans.
PG  - 561-5
AB  - BACKGROUND: Tumours of the parotid gland are generally managed surgically without
      reconstruction. The usual long-term outcomes of these techniques are facial
      scars, asymmetry, and permanent contour deficits. These cosmetic deformities can 
      significantly affect patients' self-image and negatively impact their quality of 
      life. Free tissue transfers have been used increasingly over the past years to
      improve patients' cosmetic and satisfaction outcomes. OBJECTIVE: The purpose of
      this study was to evaluate the cosmetic and symmetry outcomes of patients
      undergoing free flap reconstruction after parotid surgery. METHODS: The study was
      approved by the ethics review board at the University of Alberta. All patients
      undergoing total parotid surgery were offered a free flap tissue transfer
      reconstructive procedure. Seven consecutive patients undergoing the
      reconstruction option were included in the study. The control group was composed 
      of seven patients who had undergone total parotid surgery without reconstruction.
      Data regarding demographics, surgical procedure, pathology, and postoperative
      complications were collected. Facial symmetry was evaluated with questionnaires
      and laser surface scanning. RESULTS: There were no statistically significant
      differences between the two groups with regard to age, sex, timing of surgery, or
      pathology. The reconstructed patients tended to perceive a better symmetry when
      compared to the nonreconstructed patients (p = .0014). The reconstructed patients
      had all experienced a slight volume increase on the operative side compared to
      the contralateral side, with a mean difference of 4.99% increase in volume.
      Conversely, the nonreconstructed patients all experienced a notable volume
      deficit on the operative side compared to the nonoperative side-an average 12.15%
      volume loss was seen postoperatively. This difference was statistically
      significant (p </= .0001). CONCLUSIONS: Free tissue transfer reconstruction is an
      effective means of reconstructing postparotidectomy defects in patients for whom 
      facial volume asymmetry is a concern.
FAU - Cote, David
AU  - Cote D
AD  - Division of Otolaryngology-Head and Neck Surgery, University of Alberta,
      Edmonton, AB.
FAU - Harris, Jeffrey R
AU  - Harris JR
FAU - Guillemaud, Jennifer
AU  - Guillemaud J
FAU - Chau, Jason K M
AU  - Chau JK
FAU - Grosvenor, Andrew
AU  - Grosvenor A
FAU - King, Benjamin
AU  - King B
FAU - Seikaly, Hadi
AU  - Seikaly H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - J Otolaryngol Head Neck Surg
JT  - Journal of otolaryngology - head & neck surgery = Le Journal
      d'oto-rhino-laryngologie et de chirurgie cervico-faciale
JID - 101479544
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Imaging, Three-Dimensional/*methods
MH  - *Lasers
MH  - Male
MH  - Middle Aged
MH  - Muscle, Skeletal/*transplantation
MH  - Parotid Neoplasms/*surgery
MH  - Patient Satisfaction
MH  - Quality of Life
MH  - Reconstructive Surgical Procedures/*methods
MH  - *Surgical Flaps
MH  - Treatment Outcome
EDAT- 2010/09/11 06:00
MHDA- 2011/02/02 06:00
CRDT- 2010/09/11 06:00
PHST- 2010/09/11 06:00 [entrez]
PHST- 2010/09/11 06:00 [pubmed]
PHST- 2011/02/02 06:00 [medline]
PST - ppublish
SO  - J Otolaryngol Head Neck Surg. 2010 Oct;39(5):561-5.


PMID- 20828039
OWN - NLM
STAT- MEDLINE
DCOM- 20101005
LR  - 20191210
IS  - 0882-1577 (Print)
IS  - 0882-1577 (Linking)
VI  - 91
IP  - 5
DP  - 2010 Sep-Oct
TI  - Health care ethics and rural life. Stigma, privacy, boundary conflicts raise
      concerns.
PG  - 50-4
FAU - Nelson, William A
AU  - Nelson WA
AD  - Dartmouth Medical School, Hanover, NH, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Health Prog
JT  - Health progress (Saint Louis, Mo.)
JID - 8500263
MH  - *Confidentiality
MH  - *Conflict, Psychological
MH  - Humans
MH  - Rural Health Services/*ethics
MH  - *Stereotyping
EDAT- 2010/09/11 06:00
MHDA- 2010/10/06 06:00
CRDT- 2010/09/11 06:00
PHST- 2010/09/11 06:00 [entrez]
PHST- 2010/09/11 06:00 [pubmed]
PHST- 2010/10/06 06:00 [medline]
PST - ppublish
SO  - Health Prog. 2010 Sep-Oct;91(5):50-4.


PMID- 20828023
OWN - NLM
STAT- MEDLINE
DCOM- 20101129
LR  - 20100910
IS  - 1592-5986 (Print)
IS  - 1592-5986 (Linking)
VI  - 29
IP  - 2
DP  - 2010 Apr-Jun
TI  - [Genomics in medicine: challenges and perspectives for the nursing care].
PG  - 62-8
AB  - INTRODUCTION: The acknowledgment of the genetic component in the majority of
      pathologies, not only hereditary or oncological, and of the individual biological
      responses to therapies and in infectious diseases, is now granted. AIMS: The
      current developments of the genomic fuel new expectations on the modification of 
      medical approach to prevention, diagnosis and therapy of main pathologies,
      through diagnostic genetic tests, predictive tests and new drugs, towards a
      "personalized medicine". RESULTS: However, the introduction of the desired
      benefits to medicine and care derived from this knowledge requires the awareness 
      of health operators of the ethical, social and economical implications of
      genetics and the estimated risks and opportunities of the genetic information.
      Nurses should update their knowledge and acquire new competencies in genetics, to
      be able to answer the new questions that the patients place, especially when
      affected by genetic diseases. This article offers an update on the practical
      implications of the genomic knowledge on genetic testing, pharmacogenomics,
      genetic therapy, determination of the genetic risk and on the role of the genetic
      nurse.
FAU - Romanelli, Maria Grazia
AU  - Romanelli MG
AD  - Docente Corso di Laurea in Infermieristica, Dip. Scienze della Vita e della
      Riproduzione, Universita di Verona.
FAU - Pressi, Laura
AU  - Pressi L
FAU - Regele, Maria
AU  - Regele M
FAU - Castellan, Claudio
AU  - Castellan C
LA  - ita
PT  - English Abstract
PT  - Journal Article
TT  - La genomica in medicina: attualita e prospettive per l'assistenza
      infermieristica.
PL  - Italy
TA  - Assist Inferm Ric
JT  - Assistenza infermieristica e ricerca : AIR
JID - 100901776
MH  - *Genetics, Medical
MH  - *Genomics
MH  - *Nursing
EDAT- 2010/09/11 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/09/11 06:00
PHST- 2010/09/11 06:00 [entrez]
PHST- 2010/09/11 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - Assist Inferm Ric. 2010 Apr-Jun;29(2):62-8.


PMID- 20827724
OWN - NLM
STAT- MEDLINE
DCOM- 20110113
LR  - 20100927
IS  - 1935-9780 (Electronic)
IS  - 1935-9772 (Linking)
VI  - 3
IP  - 5
DP  - 2010 Sep-Oct
TI  - Students as resurrectionists--A multimodal humanities project in anatomy putting 
      ethics and professionalism in historical context.
PG  - 244-8
LID - 10.1002/ase.174 [doi]
AB  - Because medical students have many different learning styles, the authors,
      medical students at Mayo Clinic, College of Medicine researched the history of
      anatomical specimen procurement, reviewing topic-related film, academic
      literature, and novels, to write, direct, and perform a dramatization based on
      Robert Louis Stevenson's The Body-Snatcher. Into this performance, they
      incorporated dance, painting, instrumental and vocal performance, and creative
      writing. In preparation for the performance, each actor researched an aspect of
      the history of anatomy. These micro-research projects were presented in a lecture
      before the play. Not intended to be a research study, this descriptive article
      discusses how student research and ethics discussions became a theatrical
      production. This addition to classroom and laboratory learning addresses the deep
      emotional response experienced by some students and provides an avenue to
      understand and express these feelings. This enhanced multimodal approach
      to"holistic learning" could be applied to any topic in the medical school
      curriculum, thoroughly adding to the didactics with history, humanities, and team
      dynamics.
FAU - Hammer, Rachel R
AU  - Hammer RR
AD  - Mayo Medical School, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
      hammer.rachel@mayo.edu
FAU - Jones, Trahern W
AU  - Jones TW
FAU - Hussain, Fareeda Taher Nazer
AU  - Hussain FT
FAU - Bringe, Kariline
AU  - Bringe K
FAU - Harvey, Ronee E
AU  - Harvey RE
FAU - Person-Rennell, Nicole H
AU  - Person-Rennell NH
FAU - Newman, James S
AU  - Newman JS
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - Anat Sci Educ
JT  - Anatomical sciences education
JID - 101392205
SB  - IM
MH  - Anatomy/ethics/*history
MH  - Cadaver
MH  - Crime/history
MH  - Curriculum
MH  - Dancing
MH  - Dissection/history
MH  - Drama
MH  - Emotions
MH  - Group Processes
MH  - History, 19th Century
MH  - History, 20th Century
MH  - History, 21st Century
MH  - *Humanities
MH  - Humans
MH  - Learning
MH  - Minnesota
MH  - Music
MH  - Paintings
MH  - Professional Role/*history
MH  - Schools, Medical
MH  - *Students, Medical/psychology
MH  - Tissue and Organ Procurement/history
EDAT- 2010/09/10 06:00
MHDA- 2011/01/14 06:00
CRDT- 2010/09/10 06:00
PHST- 2010/09/10 06:00 [entrez]
PHST- 2010/09/10 06:00 [pubmed]
PHST- 2011/01/14 06:00 [medline]
AID - 10.1002/ase.174 [doi]
PST - ppublish
SO  - Anat Sci Educ. 2010 Sep-Oct;3(5):244-8. doi: 10.1002/ase.174.


PMID- 20827499
OWN - NLM
STAT- MEDLINE
DCOM- 20110609
LR  - 20211203
IS  - 1437-7799 (Electronic)
IS  - 1342-1751 (Linking)
VI  - 15
IP  - 1
DP  - 2011 Feb
TI  - Clinical remission of Henoch-Schonlein purpura nephritis after a monotherapeutic 
      tonsillectomy.
PG  - 132-5
LID - 10.1007/s10157-010-0345-5 [doi]
AB  - We herein describe an adult male patient who presented with tonsillitis, purpura,
      hematuria, and proteinuria. The serological analyses revealed elevated serum
      antistreptolysin, and the throat culture yielded Lancefield group A
      beta-hemolytic streptococci. A renal biopsy revealed mild mesangial proliferation
      associated with granular mesangial depositions of IgA and C3, consistent with
      Henoch-Schonlein purpura nephritis (HSPN). Initially, the patient was treated
      with dipyridamole, which was followed by limited improvements in the proteinuria 
      and hematuria. Nine months later, the tonsillitis relapsed due to GAS infection
      and deteriorated urinary abnormalities were noticed, which finally disappeared
      after monotherapeutic tonsillectomy. Although the impact of tonsillectomy on the 
      treatment of HSPN remains to be characterized, our observations suggest that
      tonsillectomy in the present patient played a pivotal role in facilitating the
      recovery of the renal injuries. Because the arbitrary application of a
      tonsillectomy appears to be accompanied by ethical concerns, the evaluation of
      the clinical benefits of this procedure should be addressed more directly in the 
      future.
FAU - Iwazu, Yoshitaka
AU  - Iwazu Y
AD  - Division of Nephrology, Department of Internal Medicine, Jichi Medical
      University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan.
FAU - Akimoto, Tetsu
AU  - Akimoto T
FAU - Muto, Shigeaki
AU  - Muto S
FAU - Kusano, Eiji
AU  - Kusano E
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20100909
PL  - Japan
TA  - Clin Exp Nephrol
JT  - Clinical and experimental nephrology
JID - 9709923
SB  - IM
MH  - Adult
MH  - Glomerulonephritis, IGA/*etiology/pathology/*surgery
MH  - Humans
MH  - IgA Vasculitis/*complications/pathology/*surgery
MH  - Male
MH  - *Tonsillectomy
EDAT- 2010/09/10 06:00
MHDA- 2011/06/10 06:00
CRDT- 2010/09/10 06:00
PHST- 2010/06/07 00:00 [received]
PHST- 2010/08/16 00:00 [accepted]
PHST- 2010/09/10 06:00 [entrez]
PHST- 2010/09/10 06:00 [pubmed]
PHST- 2011/06/10 06:00 [medline]
AID - 10.1007/s10157-010-0345-5 [doi]
PST - ppublish
SO  - Clin Exp Nephrol. 2011 Feb;15(1):132-5. doi: 10.1007/s10157-010-0345-5. Epub 2010
      Sep 9.


PMID- 20827353
OWN - NLM
STAT- MEDLINE
DCOM- 20110125
LR  - 20211020
IS  - 1866-0452 (Electronic)
IS  - 1866-0452 (Linking)
VI  - 107
IP  - 31-32
DP  - 2010 Aug
TI  - Sample size calculation in clinical trials: part 13 of a series on evaluation of 
      scientific publications.
PG  - 552-6
LID - 10.3238/arztebl.2010.0552 [doi]
AB  - BACKGROUND: In this article, we discuss the purpose of sample size calculation in
      clinical trials, the need for it, and the methods by which it is accomplished.
      Study samples that are either too small or too large are unacceptable, for
      clinical, methodological, and ethical reasons. The physicians participating in
      clinical trials should be directly involved in sample size planning, because
      their expertise and knowledge of the literature are indispensable. METHODS: We
      explain the process of sample size calculation on the basis of articles retrieved
      by a selective search of the international literature, as well as our own
      experience. RESULTS: We present a fictitious clinical trial in which two
      antihypertensive agents are to be compared to each other with a t-test and then
      show how the appropriate size of the study sample should be calculated. Next, we 
      describe the general principles of sample size calculation that apply when any
      kind of statistical test is to be used. We give further illustrative examples and
      explain what types of expert medical knowledge and assumptions are needed to
      calculate the appropriate sample size for each. These generally depend on the
      particular statistical test that is to be performed. CONCLUSION: In any clinical 
      trial, the sample size has to be planned on a justifiable, rational basis. The
      purpose of sample size calculation is to determine the optimal number of
      participants (patients) to be included in the trial. Sample size calculation
      requires the collaboration of experienced biostatisticians and
      physician-researchers: expert medical knowledge is an essential part of it.
FAU - Rohrig, Bernd
AU  - Rohrig B
AD  - Medizinischer Dienst der Krankenversicherung Rheinland-Pfalz (MDK), Referat
      Rehabilitation/Biometrie.
FAU - du Prel, Jean-Baptist
AU  - du Prel JB
FAU - Wachtlin, Daniel
AU  - Wachtlin D
FAU - Kwiecien, Robert
AU  - Kwiecien R
FAU - Blettner, Maria
AU  - Blettner M
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100809
PL  - Germany
TA  - Dtsch Arztebl Int
JT  - Deutsches Arzteblatt international
JID - 101475967
SB  - IM
MH  - Clinical Trials as Topic/*statistics & numerical data
MH  - *Data Interpretation, Statistical
MH  - *Journal Impact Factor
MH  - *Meta-Analysis as Topic
MH  - Periodicals as Topic/*statistics & numerical data
MH  - *Sample Size
PMC - PMC2933537
EDAT- 2010/09/10 06:00
MHDA- 2011/01/28 06:00
CRDT- 2010/09/10 06:00
PHST- 2010/01/15 00:00 [received]
PHST- 2010/03/22 00:00 [accepted]
PHST- 2010/09/10 06:00 [entrez]
PHST- 2010/09/10 06:00 [pubmed]
PHST- 2011/01/28 06:00 [medline]
AID - 10.3238/arztebl.2010.0552 [doi]
PST - ppublish
SO  - Dtsch Arztebl Int. 2010 Aug;107(31-32):552-6. doi: 10.3238/arztebl.2010.0552.
      Epub 2010 Aug 9.


PMID- 20827251
OWN - NLM
STAT- MEDLINE
DCOM- 20110218
LR  - 20100909
IS  - 0026-4784 (Print)
IS  - 0026-4784 (Linking)
VI  - 62
IP  - 4
DP  - 2010 Aug
TI  - Social and ethical determinants of human sexuality: 1. The need to reproduce.
PG  - 349-59
AB  - Aims of this study was to review the many and diverse factors conditioning human 
      sexual behavior; starting with the first and still most important: the need to
      reproduce and to analyse these factors and how they have changed over time in
      order to better understand the interplay between the major determinants of human 
      sexuality. For this aim the authors made a literature review of relevant
      scientific papers and books, including religious websites. At the dawn of
      humanity, sexuality was focused on reproduction; this, however, did not exclude
      other important meanings in sexual relationships, since non-conceptive
      copulations have been a constant aspect of human behavior, becoming an almost
      unique feature of genus homo. In this respect, the characteristics of a female
      continuously accessible to her male set the stage for a trend towards monogamy
      and created the substrate for closed families. Anthropologists have justified
      conceptive sexuality because sexual activity is costly in terms of energy
      consumption; for this reason, in the early days, restricting sexual activity made
      sense for the survival of the species. Traditional ethical considerations and
      ancient norms by the three major monotheistic religions have favored conceptive
      sexuality, restricting sexual activity to sanctioned unions and insisting that
      the major scope of sexuality is procreation. In spite of this, among humans
      sexuality has always had a wider meaning to the point that for millennia, humans 
      have tried to separate its unitive and procreative meanings. Today much has
      changed since reproduction can be achieved without intercourse, further
      separating it from sexual activity. In humans sexuality always possessed multiple
      meanings, first and foremost reproduction and the creation of a bond between a
      man and one or several women.
FAU - Benagiano, G
AU  - Benagiano G
AD  - Department of Obstetrics and Gynecology, La Sapienza University, Rome, Italy.
      giuseppe.benagiano@uniroma1.it
FAU - Carrara, S
AU  - Carrara S
FAU - Filippi, V
AU  - Filippi V
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - Minerva Ginecol
JT  - Minerva ginecologica
JID - 0400731
SB  - IM
MH  - Christianity/psychology
MH  - Female
MH  - Fertilization in Vitro/ethics
MH  - Homosexuality/ethics
MH  - Humans
MH  - Islam/psychology
MH  - Judaism/psychology
MH  - Male
MH  - Morals
MH  - *Object Attachment
MH  - *Religion
MH  - Reproduction/*ethics
MH  - Sexual Behavior/ethics
MH  - Sexuality/*ethics/psychology
MH  - *Social Behavior
EDAT- 2010/09/10 06:00
MHDA- 2011/02/22 06:00
CRDT- 2010/09/10 06:00
PHST- 2010/09/10 06:00 [entrez]
PHST- 2010/09/10 06:00 [pubmed]
PHST- 2011/02/22 06:00 [medline]
AID - R09103134 [pii]
PST - ppublish
SO  - Minerva Ginecol. 2010 Aug;62(4):349-59.


PMID- 20827128
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20110825
IS  - 1932-8095 (Electronic)
IS  - 1932-8087 (Linking)
VI  - 15
IP  - 5
DP  - 2010 Sep-Oct
TI  - Speaking up in case management, part II: implementing speaking up behaviors.
PG  - 237-42; quiz 243-4
LID - 10.1097/NCM.0b013e3181e94441 [doi]
AB  - OBJECTIVES: Case managers will occasionally witness colleagues from their own or 
      other healthcare disciplines providing care in ways that frankly deviate from or 
      violate standards of care, rules, regulations, policies, and procedures. This
      article discusses the case manager's ethical obligation to speak up in such
      instances, as well as lists strategies and techniques that facilitate and enhance
      professional communications around "speaking up." PRIMARY PRACTICE SETTINGS: All 
      case management work environments. FINDINGS/CONCLUSIONS: When healthcare
      professionals practice in ways that deviate from established policies,
      procedures, rules, regulations, and standards of care, they jeopardize the safety
      and welfare of their clients and, often, their employing institutions.
      Unfortunately, professionals often remain silent about such errors and deviations
      for fear that they might suffer retaliation if they speak up or because they do
      not anticipate a constructive or positive organizational response. Nevertheless, 
      organizations and employees who recognize the value of speaking up can use a
      variety of strategies described in this article that enable speaking up to become
      a professional and organizational reality. IMPLICATIONS FOR CASE MANAGEMENT
      PRACTICE: Because they practice in the midst of multidisciplinary care, case
      managers have a marked opportunity to witness any number of practice standards
      being ignored or violated. Case managers need to develop communication skills and
      organizational savvy regarding how to approach and remedy such situations,
      especially when deviations from standards of care have become routine or
      "normalized." Critical elements in speaking up include cultivating a method to
      discern the moral perils of remaining silent, learning communication techniques
      to conduct emotionally challenging conversations, and building organizational
      leadership that recognizes the value of speaking up and supports safe harbors for
      employees who speak up appropriately.
FAU - Banja, John D
AU  - Banja JD
AD  - Department of Rehabilitation Medicine, Emory University, Atlanta, GA 30322, USA. 
      jbanja@emory.edu
FAU - Craig, Kathy
AU  - Craig K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Prof Case Manag
JT  - Professional case management
JID - 101291585
MH  - *Case Management
MH  - *Communication
MH  - Humans
MH  - Leadership
MH  - Nurse's Role
MH  - Nursing Care/*methods/trends
MH  - *Professional Role
MH  - Professional-Patient Relations
MH  - Social Environment
MH  - Work
EDAT- 2010/09/10 06:00
MHDA- 2011/01/07 06:00
CRDT- 2010/09/10 06:00
PHST- 2010/09/10 06:00 [entrez]
PHST- 2010/09/10 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
AID - 10.1097/NCM.0b013e3181e94441 [doi]
AID - 01269241-201009000-00003 [pii]
PST - ppublish
SO  - Prof Case Manag. 2010 Sep-Oct;15(5):237-42; quiz 243-4. doi:
      10.1097/NCM.0b013e3181e94441.


PMID- 20826963
OWN - NLM
STAT- MEDLINE
DCOM- 20101222
LR  - 20151119
IS  - 0974-5181 (Electronic)
IS  - 0971-9784 (Linking)
VI  - 13
IP  - 3
DP  - 2010 Sep-Dec
TI  - Thoracic epidural analgesia for off-pump coronary artery bypass surgery in
      patients with chronic obstructive pulmonary disease.
PG  - 224-30
LID - 10.4103/0971-9784.69062 [doi]
AB  - The benefits of thoracic epidural analgesia in patients undergoing coronary
      artery bypass grafting are well documented. However, the literature available on 
      the role of high thoracic epidural analgesia (HTEA) in patients with chronic
      obstructive pulmonary disease undergoing off-pump coronary artery bypass graft
      (OPCAB) surgery is scarce. We conducted a randomized clinical trial to establish 
      whether HTEA is beneficial in patients with chronic obstructive pulmonary disease
      undergoing elective OPCAB surgery. After institutional ethics board approval and 
      informed consent, 62 chronic obstructive pulmonary disease patients undergoing
      elective OPCAB were randomly grouped into two (n = 31 each). Both groups received
      general anesthesia (GA), but in the HTEA group patients, TEA was also
      administered. Standardized surgical and anesthetic techniques were used for both 
      the groups. Pulmonary function tests were performed pre-operatively, 6 h and 24 h
      post-extubation and on days 2, 3, 4 and 5 along with arterial blood gas analysis 
      (ABG) analysis. Time for extubation (h) and time for oxygen withdrawal (h) were
      recorded. Pain score was assessed by the 10-cm visual analogue scale. All
      hemodynamic/oxygenation parameters were noted. Any complications related to the
      TEA were also recorded. Patients in the HTEA group were extubated earlier (10.8 h
      vs. 13.5 h, P < 0.01) and their oxygen withdrawal time was also significantly
      lower (26.26 h vs. 29.87 h, P < 0.01). The VAS score, both at rest and on
      coughing, was significantly lower in the HTEA group at all times,
      post-operatively (P < 0.01). The forced vital capacity improved significantly at 
      6 h post-operatively in the HTEA group (P = 0.026) and remained significantly
      higher thereafter. A similar trend was observed in forced expiratory volume in
      the first second on day 2 in the HTEA group (P = 0.024). We did not observe any
      significant side-effects/mortality in either group. In chronic obstructive
      pulmonary disease patients undergoing elective OPCAB surgery, HTEA is a good
      adjunct to GA for early extubation, faster recovery of pulmonary function and
      better analgesia.
FAU - Mehta, Yatin
AU  - Mehta Y
AD  - Department of Anesthesiology, Critical Care and Cardiothoracic Surgery,
      Indraprastha Apollo Hospital, New Delhi, India. drmayankvats@gmail.com
FAU - Vats, Mayank
AU  - Vats M
FAU - Sharma, Munish
AU  - Sharma M
FAU - Arora, Reetesh
AU  - Arora R
FAU - Trehan, Naresh
AU  - Trehan N
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - India
TA  - Ann Card Anaesth
JT  - Annals of cardiac anaesthesia
JID - 9815987
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Aged
MH  - *Analgesia, Epidural/adverse effects
MH  - Anesthesia, General
MH  - Blood Gas Analysis
MH  - *Coronary Artery Bypass, Off-Pump
MH  - Critical Care
MH  - Female
MH  - Hemodynamics/drug effects
MH  - Humans
MH  - Length of Stay
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/epidemiology
MH  - Oxygen/blood
MH  - Pain Measurement
MH  - Postoperative Complications/epidemiology
MH  - Pulmonary Disease, Chronic Obstructive/*complications
MH  - Respiratory Function Tests
EDAT- 2010/09/10 06:00
MHDA- 2010/12/24 06:00
CRDT- 2010/09/10 06:00
PHST- 2010/09/10 06:00 [entrez]
PHST- 2010/09/10 06:00 [pubmed]
PHST- 2010/12/24 06:00 [medline]
AID - AnnCardAnaesth_2010_13_3_224_69062 [pii]
AID - 10.4103/0971-9784.69062 [doi]
PST - ppublish
SO  - Ann Card Anaesth. 2010 Sep-Dec;13(3):224-30. doi: 10.4103/0971-9784.69062.


PMID- 20826869
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20100930
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 10
DP  - 2010 Oct
TI  - Ethical issues related to computerised family medical histories in sickle cell
      disease: Inforare.
PG  - 604-7
LID - 10.1136/jme.2009.034066 [doi]
AB  - The Inforare project aims to set up a system for the sharing of clinical and
      familial data, in order to study how genes are related to the severity of sickle 
      cell disease. While the computerisation of clinical records represents a valuable
      research goal, an ethical framework is necessary to guarantee patients'
      protection and their rights in this developing field. Issues relating to patient 
      information during the Inforare study were analysed by the steering committee.
      Several major concerns were discussed by the committee and formalized in the
      patients' information letter: educating patients to aid the recruitment of family
      members, rules of confidentiality and the disclosure of aggregate, individual and
      unexpected research results. This paper presents the main issues addressed.
FAU - Franrenet, Sandra
AU  - Franrenet S
AD  - Laboratoire d'Ethique Medicale et Medecine Legale, Faculte de medecine de Paris
      Descartes, 45 rue des Saints-Peres, Paris 75006, France.
      sandra.franrenet@gmail.com
FAU - Duchange, Nathalie
AU  - Duchange N
FAU - Galacteros, Frederic
AU  - Galacteros F
FAU - Quantin, Catherine
AU  - Quantin C
FAU - Cohen, Olivier
AU  - Cohen O
FAU - Nzouakou, Ruben
AU  - Nzouakou R
FAU - Sudraud, Sophie
AU  - Sudraud S
FAU - Herve, Christian
AU  - Herve C
FAU - Moutel, Gregoire
AU  - Moutel G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100908
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Anemia, Sickle Cell/*genetics
MH  - *Confidentiality
MH  - Data Collection/methods
MH  - *Disclosure
MH  - Ethics, Medical
MH  - Family
MH  - Humans
MH  - Medical Records Systems, Computerized/*ethics
MH  - *Patient Rights
EDAT- 2010/09/10 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/09/10 06:00
PHST- 2010/09/10 06:00 [entrez]
PHST- 2010/09/10 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - jme.2009.034066 [pii]
AID - 10.1136/jme.2009.034066 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Oct;36(10):604-7. doi: 10.1136/jme.2009.034066. Epub 2010 Sep 
      8.


PMID- 20826868
OWN - NLM
STAT- MEDLINE
DCOM- 20110315
LR  - 20101129
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 12
DP  - 2010 Dec
TI  - Why do patients want information if not to take part in decision making?
PG  - 834-7
LID - 10.1136/jme.2010.036491 [doi]
AB  - There is empirical evidence that many patients want information about treatment
      options even though they do not want to take a full part in decision-making about
      treatment. Such evidence may have considerable ethical implications but is
      methodologically problematic. It is argued here that, in fact, it is not at all
      surprising that patients' informational interests should be separable from (and
      often stronger than) their interests in decision-making. A number of different
      reasons for wanting information are offered, some to do with the content of
      information; some with the process, others with the fact or occasion of
      informing. This philosophical clarification leads to some suggestions for further
      empirical study.
FAU - Manson, Neil C
AU  - Manson NC
AD  - Department of Philosophy, Lancaster University, Lancaster LA1 4YG, UK.
      n.manson@lancaster.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20100908
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Decision Making
MH  - Humans
MH  - Informed Consent
MH  - *Patient Education as Topic
MH  - Patient Participation/*psychology
MH  - Patient Satisfaction
MH  - Physician-Patient Relations
EDAT- 2010/09/10 06:00
MHDA- 2011/03/16 06:00
CRDT- 2010/09/10 06:00
PHST- 2010/09/10 06:00 [entrez]
PHST- 2010/09/10 06:00 [pubmed]
PHST- 2011/03/16 06:00 [medline]
AID - jme.2010.036491 [pii]
AID - 10.1136/jme.2010.036491 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Dec;36(12):834-7. doi: 10.1136/jme.2010.036491. Epub 2010 Sep 
      8.


PMID- 20826377
OWN - NLM
STAT- MEDLINE
DCOM- 20101022
LR  - 20151119
IS  - 0030-6002 (Print)
IS  - 0030-6002 (Linking)
VI  - 151
IP  - 38
DP  - 2010 Sep 19
TI  - [Practice of treatment restriction in Hungarian intensive care units].
PG  - 1530-6
LID - 10.1556/OH.2010.28950 [doi]
AB  - UNLABELLED: End of life decisions affect most of patients in intensive care
      units, thus, it is important to know both local and international practice in
      accordance with law and ethical principles for intensive care physicians. AIM: To
      search for local customs of end of life decisions (withholding or withdrawing the
      therapy, shortening of the dying process), and to compare the data with the
      international literature. METHODS: In 2007-2008 the first Hungarian survey was
      performed with the purpose to learn more about local practice of end of life
      decisions. Questionnaires were sent out electronically to 743 registered members 
      of Hungarian Society of Anesthesiology and Intensive Care. Respecting anonymity, 
      103 replies were statistically evaluated (response rate was 13.8%) and compared
      with data from other European countries. RESULTS: As expected, it turned out from
      replies that the practice of domestic intensive care physicians is very paternal 
      and this is promoted by legal regulations that share a similar character.
      Intensive care physicians generally make their decisions alone (3.75/5 point)
      without respecting the opinion of the patient (2.57/5 point) the relatives
      (2.14/5 point) or other medical personnel (2.37/5 point). Furthermore, they
      prefer not to start a therapy rather than withdraw an ongoing treatment.
      Nevertheless, the frequency of end of life decisions (3-9% of ICU patients) is
      smaller than other European countries. CONCLUSIONS: There is a need for the
      expansion of patients' right in our country. For end of life decisions, self
      determinations must be supported and a dialogue must be established between
      lawmakers and physicians, in order to improve the legal support of this medical
      practice.
FAU - Zubek, Laszlo
AU  - Zubek L
AD  - Semmelweis Egyetem, Altalanos Orvostudomanyi Kar, Aneszteziologiai es Intenziv
      Terapias Klinika, Budapest. lzubek@freemail.hu
FAU - Szabo, Lena
AU  - Szabo L
FAU - Gal, Janos
AU  - Gal J
FAU - Ollos, Adam
AU  - Ollos A
FAU - Elo, Gabor
AU  - Elo G
LA  - hun
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
TT  - A kezeleskorlatozas gyakorlata a hazai intenziv osztalyokon.
PL  - Hungary
TA  - Orv Hetil
JT  - Orvosi hetilap
JID - 0376412
SB  - IM
MH  - Ambulatory Care Facilities
MH  - Critical Care/ethics/legislation & jurisprudence/methods/*statistics & numerical 
      data
MH  - *Decision Making
MH  - Employment
MH  - Ethics, Clinical
MH  - Ethics, Medical
MH  - Europe
MH  - Euthanasia, Passive/ethics/statistics & numerical data
MH  - Female
MH  - Hospitals, County/statistics & numerical data
MH  - Hospitals, Municipal/statistics & numerical data
MH  - Hospitals, University/statistics & numerical data
MH  - Humans
MH  - Hungary
MH  - Intensive Care Units
MH  - Male
MH  - Medical Futility
MH  - *Paternalism
MH  - *Patient Rights
MH  - *Personal Autonomy
MH  - *Resuscitation Orders/ethics
MH  - Sex Distribution
MH  - Societies, Medical
MH  - Surveys and Questionnaires
MH  - Terminal Care/ethics/methods/*statistics & numerical data
MH  - Time Factors
MH  - Withholding Treatment/ethics/*statistics & numerical data
EDAT- 2010/09/10 06:00
MHDA- 2010/10/23 06:00
CRDT- 2010/09/10 06:00
PHST- 2010/09/10 06:00 [entrez]
PHST- 2010/09/10 06:00 [pubmed]
PHST- 2010/10/23 06:00 [medline]
AID - 4U4U449317127K71 [pii]
AID - 10.1556/OH.2010.28950 [doi]
PST - ppublish
SO  - Orv Hetil. 2010 Sep 19;151(38):1530-6. doi: 10.1556/OH.2010.28950.


PMID- 20826295
OWN - NLM
STAT- MEDLINE
DCOM- 20101228
LR  - 20171116
IS  - 1558-4518 (Electronic)
IS  - 0895-7967 (Linking)
VI  - 23
IP  - 3
DP  - 2010 Sep
TI  - Treating blunt aortic injuries with endografts: pros and cons of a meta-analysis.
PG  - 176-81
LID - 10.1053/j.semvascsurg.2010.05.002 [doi]
AB  - Modern management of blunt aortic injury (BAI) is based on evidence from mostly
      well-conducted meta-analyses as surrogates for prospective randomized controlled 
      trials. There are several obvious pros and cons to this strategy. The advantages 
      rest on the fact that it is unlikely that a prospective randomized trial
      comparing open surgical repair with endovascular repair will ever be conducted
      based on ethical grounds and the apparent survival advantage and reduced
      paraplegia rates associated with an endovascular approach; pooled data from
      high-volume studies provides for higher statistical power; and a well-conducted
      meta-analysis provides the ability to control for inter-study variation. The
      disadvantages of this approach are that meta-analyses are statistical
      examinations of scientific studies and not scientific studies in and of
      themselves; sources of bias cannot be controlled by the method of the analysis;
      and a heavy reliance on published studies can create exaggerated outcomes.
      Nonetheless, the studies reviewed in this article offer the best glimpse yet at
      the truth. The evidence grade to support endovascular over open repair for BAI is
      Level II (intermediate), which suggests that the described effect is plausible
      but is not quantified precisely or may be vulnerable to bias. The recommendation 
      grade is B (provisional recommendation), which suggests that on balance of the
      evidence, endovascular repair for BAI is recommended with caution.
CI  - (c) 2010 Elsevier Inc. All rights reserved.
FAU - Starnes, Benjamin W
AU  - Starnes BW
AD  - Division of Vascular Surgery, University of Washington, Harborview Medical
      Center, 325 9th Avenue, Box 359796, Seattle, WA 98104, USA.
      starnes@u.washington.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Semin Vasc Surg
JT  - Seminars in vascular surgery
JID - 8809602
RN  - 0 (Antihypertensive Agents)
SB  - IM
MH  - Antihypertensive Agents/therapeutic use
MH  - Aorta/injuries/*surgery
MH  - Bias
MH  - *Blood Vessel Prosthesis
MH  - Blood Vessel Prosthesis Implantation/adverse effects/*instrumentation
MH  - Endovascular Procedures/adverse effects/*instrumentation
MH  - *Evidence-Based Medicine
MH  - Humans
MH  - *Meta-Analysis as Topic
MH  - Patient Selection
MH  - Practice Guidelines as Topic
MH  - Prosthesis Design
MH  - Research Design
MH  - Risk Assessment
MH  - Risk Factors
MH  - *Stents
MH  - Treatment Outcome
MH  - Wounds, Nonpenetrating/*surgery
EDAT- 2010/09/10 06:00
MHDA- 2010/12/29 06:00
CRDT- 2010/09/10 06:00
PHST- 2010/09/10 06:00 [entrez]
PHST- 2010/09/10 06:00 [pubmed]
PHST- 2010/12/29 06:00 [medline]
AID - S0895-7967(10)00032-3 [pii]
AID - 10.1053/j.semvascsurg.2010.05.002 [doi]
PST - ppublish
SO  - Semin Vasc Surg. 2010 Sep;23(3):176-81. doi: 10.1053/j.semvascsurg.2010.05.002.


PMID- 20825743
OWN - NLM
STAT- MEDLINE
DCOM- 20100920
LR  - 20131121
IS  - 1603-6824 (Electronic)
IS  - 0041-5782 (Linking)
VI  - 172
IP  - 35
DP  - 2010 Aug 30
TI  - [Reporting adverse reactions and events in randomised clinical trials].
PG  - 2381-4
AB  - "Good clinical practice" (GCP) is an international guideline on how to conduct
      clinical trials on medical products involving human participants. Danish statute 
      follows the EU trial directive (2001/20/EF) including the GCP guidelines. This
      article summarises the practical implementation of reporting adverse events and
      adverse reactions to the Danish Medicines Agency and the regional ethics
      committee based on the protocol of the ongoing Copenhagen Insulin and Metformin
      Therapy (CIMT) trial.
FAU - Hemmingsen, Bianca
AU  - Hemmingsen B
AD  - Copenhagen Trial Unit, Center for Klinisk Interventionsforskning, Rigshospitalet,
      2100 Kobenhavn O, Denmark. bh@ctu.rh.dk
FAU - Stoy, Lina
AU  - Stoy L
FAU - Wetterslev, Jorn
AU  - Wetterslev J
FAU - Tarnow, Lise
AU  - Tarnow L
FAU - Friis, Karin Bach
AU  - Friis KB
FAU - Christensen, Louise Lundby
AU  - Christensen LL
FAU - Sales, Nader
AU  - Sales N
FAU - Gluud, Christian
AU  - Gluud C
CN  - Copenhagen Insulin Metformin Therapy Trial-Gruppen
LA  - dan
PT  - English Abstract
PT  - Journal Article
TT  - Rapportering af bivirkninger og uonskede haendelser i randomiserede kliniske
      forsog.
PL  - Denmark
TA  - Ugeskr Laeger
JT  - Ugeskrift for laeger
JID - 0141730
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
RN  - 9100L32L2N (Metformin)
SB  - IM
MH  - *Adverse Drug Reaction Reporting Systems/legislation & jurisprudence/standards
MH  - Denmark
MH  - European Union
MH  - Guideline Adherence
MH  - Guidelines as Topic
MH  - Humans
MH  - Hypoglycemic Agents/adverse effects/therapeutic use
MH  - Insulin/adverse effects/therapeutic use
MH  - Metformin/adverse effects/therapeutic use
MH  - *Randomized Controlled Trials as Topic/standards
IR  - Madsbad S
FIR - Madsbad, Sten
IR  - Snorgaard O
FIR - Snorgaard, Ole
IR  - Roder M
FIR - Roder, Michael
IR  - Thorsteinsson B
FIR - Thorsteinsson, Birger
IR  - Gade-Rasmussen B
FIR - Gade-Rasmussen, Birthe
IR  - Jarlov A
FIR - Jarlov, Anne
IR  - Sneppen S
FIR - Sneppen, Simone
IR  - Duun E
FIR - Duun, Elsebeth
IR  - Jensen T
FIR - Jensen, Tonny
IR  - Mathiesen E
FIR - Mathiesen, Elisabeth
IR  - Perrild H
FIR - Perrild, Hans
IR  - Krarup T
FIR - Krarup, Thure
IR  - Vestergaard H
FIR - Vestergaard, Henrik
IR  - Nielsen F
FIR - Nielsen, Flemming
IR  - Hedetoft C
FIR - Hedetoft, Christoffer
IR  - Breum L
FIR - Breum, Leif
IR  - Christensen LL
FIR - Christensen, Louise Lundby
IR  - Lund SS
FIR - Lund, Soren S
IR  - Boesgaard TW
FIR - Boesgaard, Trine W
IR  - Tarnow L
FIR - Tarnow, Lise
IR  - Pedersen O
FIR - Pedersen, Oluf
IR  - Vaag A
FIR - Vaag, Allan
IR  - Almdal T
FIR - Almdal, Thomas
IR  - Hemmingsen B
FIR - Hemmingsen, Bianca
IR  - Wetterslev J
FIR - Wetterslev, Jorn
IR  - Gluud C
FIR - Gluud, Christian
IR  - Hansen BV
FIR - Hansen, Birgitte Visboll
IR  - Rosenfeldt M
FIR - Rosenfeldt, Mette
IR  - Salas N
FIR - Salas, Nader
EDAT- 2010/09/10 06:00
MHDA- 2010/09/21 06:00
CRDT- 2010/09/10 06:00
PHST- 2010/09/10 06:00 [entrez]
PHST- 2010/09/10 06:00 [pubmed]
PHST- 2010/09/21 06:00 [medline]
AID - VP04090153 [pii]
PST - ppublish
SO  - Ugeskr Laeger. 2010 Aug 30;172(35):2381-4.


PMID- 20825673
OWN - NLM
STAT- MEDLINE
DCOM- 20101022
LR  - 20211020
IS  - 1471-244X (Electronic)
IS  - 1471-244X (Linking)
VI  - 10
DP  - 2010 Sep 8
TI  - Borna disease virus (BDV) circulating immunocomplex positivity in addicted
      patients in the Czech Republic: a prospective cohort analysis.
PG  - 70
LID - 10.1186/1471-244X-10-70 [doi]
AB  - BACKGROUND: Borna disease virus (BDV) is an RNA virus belonging to the family
      Bornaviridae. Borna disease virus is a neurotropic virus that causes changes in
      mood, behaviour and cognition. BDV causes persistent infection of the central
      nervous system. Immune changes lead to activation of infection. Alcohol and drug 
      dependence are associated with immune impairment. METHODS: We examined the
      seropositivity of BDV circulating immunocomplexes (CIC) in patients with alcohol 
      and drug dependence and healthy individuals (blood donors). We examined 41
      addicted patients for the presence of BDV CIC in the serum by ELISA at the
      beginning of detoxification, and after eight weeks of abstinence. This is the
      first such study performed in patients with alcohol and drug dependence. RESULTS:
      BDV CIC positivity was detected in 36.59% of addicted patients on day 0 and in
      42.86% on day 56. The control group was 37.3% positive. However, we did not
      detect higher BDV CIC positivity in addicted patients in comparison with blood
      donors (p = 0.179). The significantly higher level of BDV CIC was associated with
      lower levels of GGT (gamma glutamyl transferase) (p = 0.027) and approached
      statistical significance with the lower age of addicted patients (p = 0.064). We 
      did not find any association between BDV CIC positivity and other anamnestic and 
      demographic characteristics. CONCLUSIONS: In our study addicted patients did not 
      have significantly higher levels of BDV CIC than the control group. The highest
      levels of BDV CIC were detected in patients with lower levels of GGT and a lower 
      age. TRIAL REGISTRATION: This study was approved by the ethical committee of the 
      University Hospital Medical Faculty of Charles University in Pilsen, Czech
      Republic (registration number 303/2001).
FAU - Rackova, Sylva
AU  - Rackova S
AD  - Psychiatric Department, University Hospital, Medical Faculty Charles University
      in Pilsen, Alej svobody 80, Pilsen 301 00, Czech Republic. rackova@fnplzen.cz
FAU - Janu, Lubos
AU  - Janu L
FAU - Kabickova, Hana
AU  - Kabickova H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100908
PL  - England
TA  - BMC Psychiatry
JT  - BMC psychiatry
JID - 100968559
RN  - 0 (Antibodies, Viral)
RN  - 0 (Antigen-Antibody Complex)
RN  - 0 (Antigens, Viral)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Alcoholism/*blood/immunology
MH  - Antibodies, Viral/*blood/immunology
MH  - Antigen-Antibody Complex/*blood/immunology
MH  - Antigens, Viral/blood/immunology
MH  - Behavior, Addictive/blood/immunology
MH  - Blood Donors/statistics & numerical data
MH  - Borna Disease/immunology/virology
MH  - Borna disease virus/*immunology
MH  - Cohort Studies
MH  - Czech Republic
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Substance-Related Disorders/*blood/immunology
PMC - PMC2944235
EDAT- 2010/09/10 06:00
MHDA- 2010/10/23 06:00
CRDT- 2010/09/10 06:00
PHST- 2009/09/28 00:00 [received]
PHST- 2010/09/08 00:00 [accepted]
PHST- 2010/09/10 06:00 [entrez]
PHST- 2010/09/10 06:00 [pubmed]
PHST- 2010/10/23 06:00 [medline]
AID - 1471-244X-10-70 [pii]
AID - 10.1186/1471-244X-10-70 [doi]
PST - epublish
SO  - BMC Psychiatry. 2010 Sep 8;10:70. doi: 10.1186/1471-244X-10-70.


PMID- 20825658
OWN - NLM
STAT- MEDLINE
DCOM- 20110201
LR  - 20211020
IS  - 1477-7819 (Electronic)
IS  - 1477-7819 (Linking)
VI  - 8
DP  - 2010 Sep 8
TI  - Single site laparoscopic right hemicolectomy: an oncological feasible option.
PG  - 79
LID - 10.1186/1477-7819-8-79 [doi]
AB  - INTRODUCTION: We present the first 7 cases of single site right hemicolectomy in 
      Asia using the new Single Site Laparoscopy (SSL) access system from Ethicon
      Endo-surgery. METHODS: Right hemicolectomy was performed using the new Single
      Site Laparoscopy (SSL) access system. Patient demographics, operative time,
      histology and post operative recovery and complications were collected and
      analysed. RESULTS: The median operative time was 90 mins (range 60 - 150 mins)
      and a median wound size of 2.5 cm (range 2 to 4.5 cm). The median number of lymph
      nodes harvested was 24 (range 20 to 34 lymph nodes). The median length of
      proximal margin was 70 mm (range 30 to 145 mm) and that of distal margin was 50
      mm (35 to 120 mm). All patients had a median hospital stay of 7 days (range 5 to 
      11) and there were no significant perioperative complications except for 1
      patient who had a minor myocardial event. CONCLUSION: Right hemicolectomy using
      SSL access system is feasible and safe for oncologic surgery.
FAU - Lim, Yon Kuei
AU  - Lim YK
AD  - Department of Colorectal Surgery, Singapore General Hospital, Singapore.
FAU - Ng, Kheng Hong
AU  - Ng KH
FAU - Eu, Kong Weng
AU  - Eu KW
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20100908
PL  - England
TA  - World J Surg Oncol
JT  - World journal of surgical oncology
JID - 101170544
SB  - IM
MH  - Aged
MH  - Colectomy/*methods
MH  - Colonic Neoplasms/diagnosis/*surgery
MH  - Feasibility Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Laparoscopy/*methods
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Retrospective Studies
MH  - Time Factors
MH  - Treatment Outcome
PMC - PMC2945348
EDAT- 2010/09/10 06:00
MHDA- 2011/02/02 06:00
CRDT- 2010/09/10 06:00
PHST- 2010/08/12 00:00 [received]
PHST- 2010/09/08 00:00 [accepted]
PHST- 2010/09/10 06:00 [entrez]
PHST- 2010/09/10 06:00 [pubmed]
PHST- 2011/02/02 06:00 [medline]
AID - 1477-7819-8-79 [pii]
AID - 10.1186/1477-7819-8-79 [doi]
PST - epublish
SO  - World J Surg Oncol. 2010 Sep 8;8:79. doi: 10.1186/1477-7819-8-79.


PMID- 20825600
OWN - NLM
STAT- MEDLINE
DCOM- 20110425
LR  - 20110826
IS  - 1423-0410 (Electronic)
IS  - 0042-9007 (Linking)
VI  - 100
IP  - 2
DP  - 2011 Feb
TI  - The ethics of wasting the donor's gift of buffy coat.
PG  - 256-7; author reply 258-9
LID - 10.1111/j.1423-0410.2010.01405.x [doi]
FAU - Vamvakas, E C
AU  - Vamvakas EC
LA  - eng
PT  - Comment
PT  - Letter
DEP - 20100903
PL  - England
TA  - Vox Sang
JT  - Vox sanguinis
JID - 0413606
SB  - IM
CON - Vox Sang. 2010 Jul 1;99(1):1-15. PMID: 20059760
CIN - Vox Sang. 2011 Aug;101(2):175. PMID: 21492186
MH  - Blood Donors/*ethics
MH  - Blood Platelets/cytology/*physiology
MH  - Humans
MH  - Platelet Activation
MH  - Platelet Transfusion/adverse effects/ethics/methods
MH  - Plateletpheresis/ethics/*methods
EDAT- 2010/09/10 06:00
MHDA- 2011/04/26 06:00
CRDT- 2010/09/10 06:00
PHST- 2010/09/10 06:00 [entrez]
PHST- 2010/09/10 06:00 [pubmed]
PHST- 2011/04/26 06:00 [medline]
AID - VOX1405 [pii]
AID - 10.1111/j.1423-0410.2010.01405.x [doi]
PST - ppublish
SO  - Vox Sang. 2011 Feb;100(2):256-7; author reply 258-9. doi:
      10.1111/j.1423-0410.2010.01405.x. Epub 2010 Sep 3.


PMID- 20825263
OWN - NLM
STAT- MEDLINE
DCOM- 20110107
LR  - 20121203
IS  - 1465-7309 (Electronic)
IS  - 1067-3229 (Linking)
VI  - 18
IP  - 5
DP  - 2010 Sep-Oct
TI  - Psychiatrists' relationships with industry: the principal-agent problem.
PG  - 255-65
LID - 10.3109/10673229.2010.507038 [doi]
AB  - Psychiatrists' relationships with the pharmaceutical and device industries have
      been a growing focus of attention, with questions raised about the impact of
      those relationships on prescribing practices, diagnostic criteria, practice
      guidelines, continuing education, conduct and reporting of research, and
      patients' and public trust. Indeed, these concerns exist for the medical
      profession as a whole, with various remedial measures proposed. We suggest that
      such relationships can be understood as giving rise to a "principal-agent
      problem," which occurs when an agent (here, a physician) is engaged to advance
      the interests of another party, the principal (typically a patient), but also
      faces incentives to promote other interests. Studies suggest that at least some
      relationships--which include attending industry-sponsored presentations, meeting 
      with marketing representatives, and accepting samples--can alter psychiatrists'
      and other physicians' behavior in ways that can compromise patients' interests,
      and that industry-funded research may create bias in the medical literature.
      These effects are difficult to detect in specific cases, however, because of
      asymmetries of information and may not be apparent even to physicians themselves.
      Principal-agent analysis suggests that the possible responses to such problems,
      including appeals to ethical principles, monitoring behavior, and managing
      risk-inducing situations, should include consideration of aligning agents'
      incentives with principals' interests. This type of analysis underscores the
      similarity of the issues raised by physicians' relationships with industry to
      problems that arise more generally in society, thus reducing physicians'
      potential affective responses to these issues and efforts to address them.
      Finally, such analysis directs attention to the benefits and costs of each
      alternative, thereby encouraging reliance on evidence as a basis for policy.
FAU - Appelbaum, Paul S
AU  - Appelbaum PS
AD  - Department of Psychiatry, Columbia University, New York, NY 10032, USA.
      psa21@columbia.edu
FAU - Gold, Azgad
AU  - Gold A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Harv Rev Psychiatry
JT  - Harvard review of psychiatry
JID - 9312789
SB  - IM
MH  - Biomedical Research/ethics/organization & administration
MH  - Conflict of Interest
MH  - Disclosure/ethics
MH  - Drug Industry/*ethics/organization & administration
MH  - Education, Medical/ethics/organization & administration
MH  - Health Care Sector/*ethics/organization & administration
MH  - Humans
MH  - Psychiatry/*ethics/organization & administration
EDAT- 2010/09/10 06:00
MHDA- 2011/01/08 06:00
CRDT- 2010/09/10 06:00
PHST- 2010/09/10 06:00 [entrez]
PHST- 2010/09/10 06:00 [pubmed]
PHST- 2011/01/08 06:00 [medline]
AID - 10.3109/10673229.2010.507038 [doi]
PST - ppublish
SO  - Harv Rev Psychiatry. 2010 Sep-Oct;18(5):255-65. doi:
      10.3109/10673229.2010.507038.


PMID- 20825144
OWN - NLM
STAT- MEDLINE
DCOM- 20101101
LR  - 20100909
IS  - 0210-5020 (Print)
IS  - 0210-5020 (Linking)
VI  - 33
IP  - 7-8
DP  - 2010 Jul-Aug
TI  - [Pain and suffering. Ethics aspects].
PG  - 42-6
AB  - The understanding of pain and suffering have evolved throughout the different
      stages of history. In modern times, pain, thanks to scientific and technological 
      advances has been dealt with more efficiently although there is still a long way 
      to go towards the relief of suffering due to its complexity. Good nursing care
      requires nurses to have good training as well as having the ability to relate to 
      patients. They also need professional maturity in order to deal with emotional
      problems arising from pain and suffering. New nursing theories place
      responsibility with the nurse when treating the challenges brought about by pain 
      and suffering.
FAU - Gasull, Maria
AU  - Gasull M
AD  - EUE del Hospital de la Santa Creu i Sant Pau, Barcelona.
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Dolor y sufrimiento. Aspectos eticos.
PL  - Spain
TA  - Rev Enferm
JT  - Revista de enfermeria (Barcelona, Spain)
JID - 8309920
MH  - *Ethics
MH  - Humans
MH  - Pain/*nursing
MH  - Stress, Psychological/*nursing
EDAT- 2010/09/10 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/09/10 06:00
PHST- 2010/09/10 06:00 [entrez]
PHST- 2010/09/10 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
PST - ppublish
SO  - Rev Enferm. 2010 Jul-Aug;33(7-8):42-6.


PMID- 20825056
OWN - NLM
STAT- MEDLINE
DCOM- 20101022
LR  - 20170303
IS  - 0017-0011 (Print)
IS  - 0017-0011 (Linking)
VI  - 81
IP  - 7
DP  - 2010 Jul
TI  - [Hormonal (levonorgestrel) emergency contraception--effectiveness and mechanism
      of action].
PG  - 532-6
AB  - Periodic abstinence and coitus interruptus are the most popular methods of
      contraception in Poland. Recent studies have provided us with evidence that the
      so-called "menstrual calendar" may be much less effective than it was believed.
      In these circumstances, promotion and use of safe and truly effective
      contraceptives is very important for Polish women. Emergency contraception (EC)
      is a method which could be used even in cases when other contraception methods
      have failed. Mechanism of action of levonorgestrel used for EC and possible
      disturbances in the process of implantation of the blastocyst in the endometrium,
      remain the source of heated discussion among medical professionals. The latest
      publications provide us with evidence that the use of levonorgestrel in EC
      neither alters endometrial receptivity nor impedes implantation. Hormonal EC
      effectiveness is another hot topic of gynecological endocrinology and statistics.
      There is, however, no better, safer, and more ethically accepted method of
      preventing unwanted pregnancy for patients in need of postcoital contraception.
FAU - Medard, Lech M
AU  - Medard LM
AD  - Osrodek Badan na Plodnoscia i Nieplodnoscia w Warszawie. antykoncepcja@isf.pl
FAU - Ostrowska, Lucyna
AU  - Ostrowska L
LA  - pol
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Antykoncepcja dorazna z uyciem lewonorgestrelu--skutecznosc i mechanizm
      dzialania.
PL  - Poland
TA  - Ginekol Pol
JT  - Ginekologia polska
JID - 0374641
RN  - 0 (Contraceptives, Oral, Synthetic)
RN  - 0 (Contraceptives, Postcoital, Hormonal)
RN  - 5W7SIA7YZW (Levonorgestrel)
SB  - IM
MH  - Contraception Behavior/*statistics & numerical data
MH  - Contraceptives, Oral, Synthetic/*administration & dosage
MH  - Contraceptives, Postcoital, Hormonal/*administration & dosage
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Health Services Accessibility/statistics & numerical data
MH  - Humans
MH  - Levonorgestrel/*administration & dosage
MH  - Poland
MH  - Pregnancy
MH  - Pregnancy, Unwanted/psychology
MH  - Reproductive Health Services/organization & administration
MH  - *Women's Health
RF  - 42
EDAT- 2010/09/10 06:00
MHDA- 2010/10/23 06:00
CRDT- 2010/09/10 06:00
PHST- 2010/09/10 06:00 [entrez]
PHST- 2010/09/10 06:00 [pubmed]
PHST- 2010/10/23 06:00 [medline]
PST - ppublish
SO  - Ginekol Pol. 2010 Jul;81(7):532-6.


PMID- 20824941
OWN - HMD
STAT- MEDLINE
DCOM- 20100930
LR  - 20211203
IS  - 1360-7456 (Print)
IS  - 1360-7456 (Linking)
VI  - 51
IP  - 2
DP  - 2010
TI  - Navigating fieldwork politics, practicalities and ethics in the upland
      borderlands of northern Vietnam.
PG  - 179-92
AB  - In this article, I detail and evaluate the negotiations I had to broker to
      conduct ethnographic research on marketplace vendors and trade in the upland
      borderlands of northern Vietnam. Working with the analogy of the numerous 'lines'
      I was constrained by, had to manoeuvre around, and at times crossed over, I begin
      with a discussion of the 'official lines' or state regulations imposed upon my
      research and how I worked with, or negotiated these limitations. I then reveal
      the important 'border guards' or gatekeepers, such as local state actors and also
      field assistants, who enabled or constrained access to informants in numerous
      different ways. I also highlight the logistical and practical lines that I had to
      accept and indeed, often draw, to accomplish my study. I conclude with a
      consideration of how friendships in the field drew me beyond the lines I had
      originally drawn around my research. These relationships furthered my anxiety
      over the possibilities for conducting research that ultimately contributes
      towards social justice in a constrained political setting such as that which
      presently characterises Vietnam.
FAU - Bonnin, Christine
AU  - Bonnin C
AD  - Department of Geography, McGill University, Montreal, Quebec, Canada.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - England
TA  - Asia Pac Viewp
JT  - Asia Pacific viewpoint
JID - 101091309
MH  - *Anthropology, Cultural/education/history
MH  - Cultural Characteristics
MH  - Ethics/history
MH  - Ethnicity/education/ethnology/history/legislation & jurisprudence/psychology
MH  - History, 20th Century
MH  - Humans
MH  - *Minority Groups/education/history/legislation & jurisprudence/psychology
MH  - *Observer Variation
MH  - *Research Personnel/education/history/psychology
MH  - Residence Characteristics
MH  - Rural Health/history
MH  - Rural Population/history
MH  - Social Conditions/economics/history/legislation & jurisprudence
MH  - *Social Control Policies/history
MH  - Vietnam/ethnology
EDAT- 2010/09/10 06:00
MHDA- 2010/10/01 06:00
CRDT- 2010/09/10 06:00
PHST- 2010/09/10 06:00 [entrez]
PHST- 2010/09/10 06:00 [pubmed]
PHST- 2010/10/01 06:00 [medline]
AID - 10.1111/j.1467-8373.2010.01423.x [doi]
PST - ppublish
SO  - Asia Pac Viewp. 2010;51(2):179-92. doi: 10.1111/j.1467-8373.2010.01423.x.


PMID- 20824940
OWN - HMD
STAT- MEDLINE
DCOM- 20100930
LR  - 20211203
IS  - 1360-7456 (Print)
IS  - 1360-7456 (Linking)
VI  - 51
IP  - 2
DP  - 2010
TI  - A heuristic blunder: notes on an ethnographic situation in southwest China.
PG  - 148-63
AB  - During long-term fieldwork the increasing involvement of the ethnographer in the 
      lives of others raises a series of methodological and ethical issues. These can
      become even more pronounced when one is working with ethnic minorities in a
      socialist country. Yet, a seldom acknowledged reality of ethnographic fieldwork
      experience are the 'little failures' that occur along the way, alongside
      ethnographic blunders. I argue that these are difficult to avoid and can be part 
      of an important learning process, oftentimes for both researcher and researched. 
      Through the detailed description of a blunder that the author made during his
      research in southwest China with members of the Drung ethnic minority, this
      article advocates for the heuristic value of such mishaps, suggesting that one
      can learn a lot from accidents and unexpected events while undertaking in-depth
      ethnographic fieldwork. In this case, this helped to shed light on the
      micropolitics of Drung village life in southwest Yunnan, and the place of a
      'minority nationality' in wider Chinese society.
FAU - Gros, Stephane
AU  - Gros S
AD  - Centre for Himalayan Studies, CNRS, France.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - England
TA  - Asia Pac Viewp
JT  - Asia Pacific viewpoint
JID - 101091309
MH  - Agriculture/economics/education/history/legislation & jurisprudence
MH  - *Anthropology, Cultural/education/history
MH  - China/ethnology
MH  - Ethnicity/education/ethnology/history/legislation & jurisprudence/psychology
MH  - History, 20th Century
MH  - Humans
MH  - *Minority Groups/education/history/legislation & jurisprudence/psychology
MH  - *Observer Variation
MH  - *Research Personnel/education/history/psychology
MH  - *Rural Health/history
MH  - Rural Population/history
MH  - Socialism/economics/history
EDAT- 2010/09/10 06:00
MHDA- 2010/10/01 06:00
CRDT- 2010/09/10 06:00
PHST- 2010/09/10 06:00 [entrez]
PHST- 2010/09/10 06:00 [pubmed]
PHST- 2010/10/01 06:00 [medline]
AID - 10.1111/j.1467-8373.2010.01421.x [doi]
PST - ppublish
SO  - Asia Pac Viewp. 2010;51(2):148-63. doi: 10.1111/j.1467-8373.2010.01421.x.


PMID- 20824939
OWN - HMD
STAT- MEDLINE
DCOM- 20100930
LR  - 20220410
IS  - 1360-7456 (Print)
IS  - 1360-7456 (Linking)
VI  - 51
IP  - 2
DP  - 2010
TI  - Challenges and dilemmas: fieldwork with upland minorities in socialist Vietnam,
      Laos and southwest China.
PG  - 121-34
AB  - The Chinese, Vietnamese and Lao spaces within the upland Southeast Asian massif, 
      sheltering over 80 million people belonging to geographically dispersed and
      politically fragmented minority populations, have only recently reopened to
      overseas academic endeavours. Undertaking social sciences research there among
      ethnic minority groups is underscored by a specific set of challenges, dilemmas, 
      and negotiations. This special issue brings together Western academics and
      post-fieldwork doctoral students from the realms of social anthropology and human
      geography, who have conducted in-depth fieldwork among ethnic minorities in
      upland southwest China, northern Vietnam, and southern Laos. The articles provide
      insights into the struggles and constraints they faced in the field, set against 
      an understanding of the historical context of field research in these locales. In
      this unique context that nowadays interweaves economic liberalisation with
      centralised and authoritarian political structures, the authors explore how they 
      have negotiated and manoeuvred access to ethnic minority voices in complex
      cultural configurations. The ethical challenges raised and methodological
      reflections offered will be insightful for others conducting fieldwork in the
      socialist margins of the Southeast Asian massif and beyond. This specific context
      is introduced here, followed by a critique of the literature on the core themes
      that contributors raise.
FAU - Turner, Sarah
AU  - Turner S
AD  - Department of Geography, McGill University, Montreal, Canada.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - England
TA  - Asia Pac Viewp
JT  - Asia Pacific viewpoint
JID - 101091309
MH  - *Agriculture/economics/education/history/legislation & jurisprudence
MH  - *Anthropology, Cultural/education/history
MH  - China/ethnology
MH  - Cultural Characteristics
MH  - Ethnicity/education/ethnology/history/legislation & jurisprudence/psychology
MH  - Geography/economics/education/history/legislation & jurisprudence
MH  - History, 20th Century
MH  - *Human Rights/economics/education/history/legislation & jurisprudence/psychology
MH  - Humans
MH  - Laos/ethnology
MH  - *Minority Groups/education/history/legislation & jurisprudence/psychology
MH  - *Political Systems/history
MH  - Race Relations/history/legislation & jurisprudence/psychology
MH  - Rural Health/history
MH  - *Rural Population/history
MH  - Vietnam/ethnology
EDAT- 2010/09/10 06:00
MHDA- 2010/10/01 06:00
CRDT- 2010/09/10 06:00
PHST- 2010/09/10 06:00 [entrez]
PHST- 2010/09/10 06:00 [pubmed]
PHST- 2010/10/01 06:00 [medline]
AID - 10.1111/j.1467-8373.2010.01419.x [doi]
PST - ppublish
SO  - Asia Pac Viewp. 2010;51(2):121-34. doi: 10.1111/j.1467-8373.2010.01419.x.


PMID- 20810086
OWN - NLM
STAT- MEDLINE
DCOM- 20110203
LR  - 20220321
IS  - 1526-3231 (Electronic)
IS  - 0749-8063 (Linking)
VI  - 26
IP  - 9 Suppl
DP  - 2010 Sep
TI  - A comparison of knot security and loop security in arthroscopic knots tied with
      newer high-strength suture materials.
PG  - S120-6
LID - 10.1016/j.arthro.2009.12.009 [doi]
AB  - PURPOSE: The purpose of this study was to compare the knot security and loop
      security of 2 sliding and 1 static arthroscopic knot tied with different types of
      suture material. METHODS: We evaluated 3 commonly used arthroscopic knots
      (surgeon's knot, Roeder knot, and Weston knot) tied with 6 different braided No. 
      2 sutures (FiberWire [Arthrex, Naples, FL]; Ethibond [Ethicon, Somerville, NJ];
      Orthocord [DePuy Mitek, Raynham, MA]; Herculine [now called HiFi; ConMed
      Linvatec, Largo, FL]; MaxBraid [Arthrotek, Warsaw, IN]; and UltraBraid [Smith &
      Nephew, Andover, MA]). Each suture loop was then mounted on a materials testing
      system, and its circumference was measured at a 5-N preload to assess each knot's
      ability to maintain a tight suture loop without slippage (loop security). Knot
      security was measured as the maximum force to failure at 3 mm of crosshead
      displacement or suture breakage during single-pull load testing. RESULTS: We
      found that tying knots with different types of suture material can affect both
      the knot security and loop security of various types of arthroscopic knots. When 
      a Roeder knot or surgeon's knot was tied, No. 2 FiberWire had the highest force
      to failure when compared with similar knots tied with other suture material (P < 
      .001). The loop security for many of the knot and suture configurations was not
      significantly different. However, No. 2 FiberWire consistently showed the
      smallest loop circumference when compared with other suture materials.
      CONCLUSIONS: Arthroscopic knots tied with No. 2 FiberWire provide superior knot
      security and similar loop security compared with other commonly used
      high-strength polyethylene suture materials. CLINICAL RELEVANCE: High-strength
      sutures exhibit unique mechanical characteristics that may vary significantly
      between suture types. In addition, knot configuration plays an important role in 
      altering these characteristics as they relate to knot security.
FAU - Lo, Ian K Y
AU  - Lo IK
AD  - Department of Surgery, University of Calgary, Calgary, Alberta, Canada.
FAU - Ochoa, Eloy Jr
AU  - Ochoa E Jr
FAU - Burkhart, Stephen S
AU  - Burkhart SS
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100531
PL  - United States
TA  - Arthroscopy
JT  - Arthroscopy : the journal of arthroscopic & related surgery : official
      publication of the Arthroscopy Association of North America and the International
      Arthroscopy Association
JID - 8506498
RN  - 0 (Ethibond)
RN  - 0 (Polyesters)
RN  - 0 (Polyethylene Terephthalates)
RN  - 31621-87-1 (Polydioxanone)
RN  - 9002-88-4 (Polyethylene)
SB  - IM
MH  - *Arthroscopy
MH  - Equipment Failure
MH  - Materials Testing
MH  - Polydioxanone
MH  - Polyesters
MH  - Polyethylene
MH  - Polyethylene Terephthalates
MH  - *Suture Techniques
MH  - *Sutures
MH  - Tensile Strength
EDAT- 2010/09/10 06:00
MHDA- 2011/02/04 06:00
CRDT- 2010/09/03 06:00
PHST- 2005/12/15 00:00 [received]
PHST- 2009/12/08 00:00 [revised]
PHST- 2009/12/10 00:00 [accepted]
PHST- 2010/09/03 06:00 [entrez]
PHST- 2010/09/10 06:00 [pubmed]
PHST- 2011/02/04 06:00 [medline]
AID - S0749-8063(09)01081-0 [pii]
AID - 10.1016/j.arthro.2009.12.009 [doi]
PST - ppublish
SO  - Arthroscopy. 2010 Sep;26(9 Suppl):S120-6. doi: 10.1016/j.arthro.2009.12.009. Epub
      2010 May 31.


PMID- 20824884
OWN - NLM
STAT- MEDLINE
DCOM- 20110120
LR  - 20120316
IS  - 1539-1612 (Electronic)
IS  - 1539-1604 (Linking)
VI  - 9
IP  - 3
DP  - 2010 Jul-Sep
TI  - Ethical considerations in industry-sponsored multiregional clinical trials.
PG  - 230-41
LID - 10.1002/pst.458 [doi]
AB  - During the last several decades, the scientific and ethics communities have
      addressed important ethical issues in medical research, resulting in the
      elaboration and adoption of concepts, guidelines, and codes. Ethical issues in
      the conduct of Multiregional Clinical Trials have attracted significant attention
      mainly in the last two decades. With the globalization of clinical research and
      the rapid expansion to countries with a limited tradition of biomedical research,
      sponsors must proactively address local ethical issues, the adequacy of oversight
      as well as the applicability and validity of data, and scientific conclusions
      drawn from diverse patient populations. This paper highlights some core ethical
      principles and milestones in medical research, and, from an industry perspective,
      it discusses ethical issues that the clinical trial team may face when conducting
      Multiregional Clinical Trials (MRCT, clinical trials conducted at sites located
      across multiple geographic regions of the world). This paper further highlights
      the areas of consensus and controversies and proposes points to consider.
CI  - Copyright (c) 2010 John Wiley & Sons, Ltd.
FAU - Ibia, Ekopimo
AU  - Ibia E
AD  - Merck & Co., Inc., Whitehouse Station, NJ, USA. Ekopimo_ibia@merck.com
FAU - Binkowitz, Bruce
AU  - Binkowitz B
FAU - Saillot, Jean-Louis
AU  - Saillot JL
FAU - Talerico, Steven
AU  - Talerico S
FAU - Koerner, Chin
AU  - Koerner C
FAU - Ferreira, Irene
AU  - Ferreira I
FAU - Agarwal, Anupam
AU  - Agarwal A
FAU - Metz, Craig
AU  - Metz C
FAU - Maman, Marianne
AU  - Maman M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Pharm Stat
JT  - Pharmaceutical statistics
JID - 101201192
SB  - IM
MH  - Biomedical Research/ethics/legislation & jurisprudence
MH  - Clinical Trials Data Monitoring Committees
MH  - Conflict of Interest
MH  - Developing Countries
MH  - Drug Industry/*ethics
MH  - Ethical Review
MH  - Ethics Committees, Research
MH  - Geography
MH  - Government Regulation
MH  - Guidelines as Topic
MH  - Helsinki Declaration
MH  - Human Experimentation
MH  - Humans
MH  - Informed Consent/ethics
MH  - *Internationality
MH  - Multicenter Studies as Topic/*ethics
MH  - Randomized Controlled Trials as Topic/*ethics
MH  - Reproducibility of Results
MH  - Research Design
MH  - Social Justice/ethics
EDAT- 2010/09/09 06:00
MHDA- 2011/01/21 06:00
CRDT- 2010/09/09 06:00
PHST- 2010/09/09 06:00 [entrez]
PHST- 2010/09/09 06:00 [pubmed]
PHST- 2011/01/21 06:00 [medline]
AID - 10.1002/pst.458 [doi]
PST - ppublish
SO  - Pharm Stat. 2010 Jul-Sep;9(3):230-41. doi: 10.1002/pst.458.


PMID- 20824462
OWN - NLM
STAT- MEDLINE
DCOM- 20101207
LR  - 20161109
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 686
DP  - 2010
TI  - Ethical aspects on rare diseases.
PG  - 493-511
LID - 10.1007/978-90-481-9485-8_27 [doi]
AB  - In this chapter we discuss several of the most relevant subjects related to
      ethics on Rare Diseases. Some general aspects are discussed such as the
      socio-psychological problems that confront the patients and their families that
      finally lead to marginalization and exclusion of patients affected by these
      diseases from the health programs, even in wealthy countries. Then we address
      problems related to diagnosis and some ethical aspects of newborn screening,
      prenatal, pre-implantation diagnosis and reference centers, as well as some
      conditions that should be met by the persons and institutions performing such
      tasks. Alternatives of solutions for the most critical situations are proposed.
      Subsequently the orphan drugs subject is discussed not only from the availability
      point of view, prizes, industrial practices, and purchasing power in developed
      and developing societies. The research related to rare disease in children and
      other especially vulnerable conditions, the need for informed consent, review
      boards or ethics comities, confidentiality of the information, biobanks and
      pharmacogenetics are discussed.
FAU - Barrera, Luis A
AU  - Barrera LA
AD  - Instituto de Errores Innatos del Metabolismo, Pontificia Universidad Javeriana,
      Carrera 7 No 43-86, Bogota, Colombia. abarrera@javeriana.edu.co
FAU - Galindo, Gilberto Cely
AU  - Galindo GC
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
SB  - IM
MH  - Adolescent
MH  - *Bioethical Issues
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Informed Consent/ethics
MH  - Male
MH  - Neonatal Screening/ethics
MH  - Orphan Drug Production/ethics
MH  - Pregnancy
MH  - Prenatal Diagnosis/ethics
MH  - *Rare Diseases/diagnosis/prevention & control/psychology/therapy
MH  - Research
MH  - Tissue Banks/ethics
EDAT- 2010/09/09 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/09/09 06:00
PHST- 2010/09/09 06:00 [entrez]
PHST- 2010/09/09 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1007/978-90-481-9485-8_27 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2010;686:493-511. doi: 10.1007/978-90-481-9485-8_27.


PMID- 20824356
OWN - NLM
STAT- MEDLINE
DCOM- 20110608
LR  - 20110225
IS  - 1573-6814 (Electronic)
IS  - 1389-9333 (Linking)
VI  - 12
IP  - 1
DP  - 2011 Feb
TI  - Ethical tissue: a not-for-profit model for human tissue supply.
PG  - 9-10
LID - 10.1007/s10561-010-9203-7 [doi]
AB  - Following legislative changes in 2004 and the establishment of the Human Tissue
      Authority, access to human tissues for biomedical research became a more onerous 
      and tightly regulated process. Ethical Tissue was established to meet the growing
      demand for human tissues, using a process that provided ease of access by
      researchers whilst maintaining the highest ethical and regulatory standards. The 
      establishment of a licensed research tissue bank entailed several key criteria
      covering ethical, legal, financial and logistical issues being met. A wide range 
      of stakeholders, including the HTA, University of Bradford, flagged LREC,
      hospital trusts and clinical groups were also integral to the process.
FAU - Adams, Kevin
AU  - Adams K
AD  - Ethical Tissue, ICT BioIncubator, University of Bradford, Bradford, UK.
      k.adams@bradford.ac.uk
FAU - Martin, Sandie
AU  - Martin S
LA  - eng
PT  - Journal Article
DEP - 20100908
PL  - Netherlands
TA  - Cell Tissue Bank
JT  - Cell and tissue banking
JID - 100965121
SB  - IM
MH  - Advisory Committees
MH  - Cooperative Behavior
MH  - Humans
MH  - *Models, Biological
MH  - *Organizations, Nonprofit
MH  - Tissue Banks/economics/*ethics/organization & administration/*supply &
      distribution
EDAT- 2010/09/09 06:00
MHDA- 2011/06/09 06:00
CRDT- 2010/09/09 06:00
PHST- 2010/06/16 00:00 [received]
PHST- 2010/07/16 00:00 [accepted]
PHST- 2010/09/09 06:00 [entrez]
PHST- 2010/09/09 06:00 [pubmed]
PHST- 2011/06/09 06:00 [medline]
AID - 10.1007/s10561-010-9203-7 [doi]
PST - ppublish
SO  - Cell Tissue Bank. 2011 Feb;12(1):9-10. doi: 10.1007/s10561-010-9203-7. Epub 2010 
      Sep 8.


PMID- 20824354
OWN - NLM
STAT- MEDLINE
DCOM- 20110608
LR  - 20161125
IS  - 1573-6814 (Electronic)
IS  - 1389-9333 (Linking)
VI  - 12
IP  - 1
DP  - 2011 Feb
TI  - Access to organs and tissues for research from the organ donor pool within the
      UK.
PG  - 15-7
LID - 10.1007/s10561-010-9205-5 [doi]
AB  - The donor organ transplant scenario offers one potential route to access
      high-quality human organs and tissues for research. There are well-established
      networks for co-ordinating organ donation events across many countries, including
      the UK, which include robust mechanisms for obtaining consent for
      ethically-approved research. Within the UK, the challenge for the next few years 
      is to facilitate this research donation with respect to regulatory pathways
      directed by the Human Tissue Act, which covers all aspects of access to human
      tissues.
FAU - Fuller, Barry J
AU  - Fuller BJ
AD  - Division of Surgery & Interventional Science, UCL & Royal Free Hospital Organ
      Transplant Service, University College London, Royal Free Campus, London, UK.
      b.fuller@medsch.ucl.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20100908
PL  - Netherlands
TA  - Cell Tissue Bank
JT  - Cell and tissue banking
JID - 100965121
SB  - IM
MH  - *Biomedical Research
MH  - Health Services Accessibility/ethics/legislation & jurisprudence/*organization & 
      administration
MH  - Humans
MH  - *Tissue Donors
MH  - Tissue and Organ Procurement/ethics/legislation & jurisprudence/*organization &
      administration
MH  - Transplantation
MH  - United Kingdom
EDAT- 2010/09/09 06:00
MHDA- 2011/06/09 06:00
CRDT- 2010/09/09 06:00
PHST- 2010/07/14 00:00 [received]
PHST- 2010/07/16 00:00 [accepted]
PHST- 2010/09/09 06:00 [entrez]
PHST- 2010/09/09 06:00 [pubmed]
PHST- 2011/06/09 06:00 [medline]
AID - 10.1007/s10561-010-9205-5 [doi]
PST - ppublish
SO  - Cell Tissue Bank. 2011 Feb;12(1):15-7. doi: 10.1007/s10561-010-9205-5. Epub 2010 
      Sep 8.


PMID- 20824352
OWN - NLM
STAT- MEDLINE
DCOM- 20110608
LR  - 20110225
IS  - 1573-6814 (Electronic)
IS  - 1389-9333 (Linking)
VI  - 12
IP  - 1
DP  - 2011 Feb
TI  - The current limitations on tissue banking from an academic perspective.
PG  - 23-4
LID - 10.1007/s10561-010-9207-3 [doi]
AB  - For research on human physiology and pathologies the most relevant results come
      from human tissue, necessitating the creation of more tissue banks. This need is 
      acknowledged by academics, clinical researchers and the pharmaceutical industry. 
      For academics, the major obstacles to establishing tissue banks are the somewhat 
      cumbersome ethical procedures, a perceived lack of demand for human tissue and
      insufficient knowledge about supply and its demographic differences. The causes
      are inter-related: confusing and time-consuming ethics applications cause some
      researchers to avoid human tissue work and expend research efforts on animal
      studies, leading to a false presumption of a lower level of demand for human
      tissue. Lack of knowledge about why rates of donation are low, and why there are 
      differences in donation for different organs, leads to an uncertainty about
      supply. This too poses a problem for tissue bank establishment, and further
      research into this area is required.
FAU - Pierscionek, Barbara K
AU  - Pierscionek BK
AD  - School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, UK.
      B.Pierscionek@ulster.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20100908
PL  - Netherlands
TA  - Cell Tissue Bank
JT  - Cell and tissue banking
JID - 100965121
SB  - IM
MH  - Animals
MH  - Databases as Topic
MH  - Humans
MH  - Tissue Banks/*ethics/*supply & distribution
MH  - *Universities
EDAT- 2010/09/09 06:00
MHDA- 2011/06/09 06:00
CRDT- 2010/09/09 06:00
PHST- 2010/05/06 00:00 [received]
PHST- 2010/07/19 00:00 [accepted]
PHST- 2010/09/09 06:00 [entrez]
PHST- 2010/09/09 06:00 [pubmed]
PHST- 2011/06/09 06:00 [medline]
AID - 10.1007/s10561-010-9207-3 [doi]
PST - ppublish
SO  - Cell Tissue Bank. 2011 Feb;12(1):23-4. doi: 10.1007/s10561-010-9207-3. Epub 2010 
      Sep 8.


PMID- 20824351
OWN - NLM
STAT- MEDLINE
DCOM- 20110608
LR  - 20161125
IS  - 1573-6814 (Electronic)
IS  - 1389-9333 (Linking)
VI  - 12
IP  - 1
DP  - 2011 Feb
TI  - Pathology: coming in from the cold.
PG  - 25-7
LID - 10.1007/s10561-010-9211-7 [doi]
AB  - Following the UK's organ retention scandals that occurred a decade ago,
      politicians unleashed a deluge of well-intentioned but naive and unnecessarily
      burdensome regulations that have progressively stymied human tissue-based
      research, stifling development of improved diagnostic and prognostic tests as
      well as discovery of new treatments based on sound knowledge of human-specific
      biology. For the UK to maintain a leading role in medical research, more sensible
      levels of regulation need to be introduced that recognise differences between
      tissue from donors who have passed-away and surgical tissue that is surplus to
      diagnostic requirements and that otherwise will be incinerated. While it is
      important to reassure the public that research using their tissues will be
      conducted within an approved ethical framework, it is equally important to ensure
      that, as hospital staff and academic researchers, we are able to fulfil our
      unwritten covenant with patients to do our utmost to seek better diagnostic
      assays and more predictive prognostic indicators, while collaborating with our
      colleagues in academia and industry and hence bring hope to patients with
      illnesses for which no effective treatments are yet available. There is a clear
      case for introducing an opt-out system as the default to allow all surplus
      surgical tissues to be immediately available for research, concomitant with an
      education campaign. This is the optimal and most ethical approach to ensure the
      wishes of the vast majority of patients are respected by allowing their residual 
      surgical tissues and relevant clinical information to be made available for
      research without the current levels of obstruction and hindrance.
FAU - Foster, Christopher S
AU  - Foster CS
AD  - Division of Pathology, Liverpool University, Duncan Building, Daulby Street,
      Liverpool, UK. csfoster@liv.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20100908
PL  - Netherlands
TA  - Cell Tissue Bank
JT  - Cell and tissue banking
JID - 100965121
SB  - IM
MH  - Animals
MH  - Delivery of Health Care
MH  - Humans
MH  - *Pathology
MH  - *Tissue Banks/legislation & jurisprudence
MH  - United Kingdom
EDAT- 2010/09/09 06:00
MHDA- 2011/06/09 06:00
CRDT- 2010/09/09 06:00
PHST- 2010/07/25 00:00 [received]
PHST- 2010/07/27 00:00 [accepted]
PHST- 2010/09/09 06:00 [entrez]
PHST- 2010/09/09 06:00 [pubmed]
PHST- 2011/06/09 06:00 [medline]
AID - 10.1007/s10561-010-9211-7 [doi]
PST - ppublish
SO  - Cell Tissue Bank. 2011 Feb;12(1):25-7. doi: 10.1007/s10561-010-9211-7. Epub 2010 
      Sep 8.


PMID- 20824349
OWN - NLM
STAT- MEDLINE
DCOM- 20110608
LR  - 20161125
IS  - 1573-6814 (Electronic)
IS  - 1389-9333 (Linking)
VI  - 12
IP  - 1
DP  - 2011 Feb
TI  - The use of functional human tissues in drug development.
PG  - 31-2
LID - 10.1007/s10561-010-9213-5 [doi]
AB  - Fresh, functional human tissues have long been considered the closest possible
      model of human in vivo function and can be used to measure a wide range of
      pharmacological responses. Despite this, relatively little drug development is
      conducted using fresh human tissue because of the logistical and ethical
      difficulties surrounding the availability of tissue and practicalities of
      experimental work. Most tests of drug activity require a living test system
      comprising cells, tissues or whole organisms. In some instances, "living" (fresh)
      human tissues have the potential to reduce or replace animal tests through
      superior prediction of drug safety and efficacy. Before functional human tissue
      tests become a routine part of drug development, two factors must co-exist.
      Firstly, organisations such as Biopta must continue to create compelling evidence
      that human tissues are more predictive than alternative models; such evidence
      will drive demand from the pharmaceutical industry for human tissue-based tests. 
      Secondly, the vast number of tissues and organs residual to surgery or unsuitable
      for transplant must be routinely consented for medical research and made
      available to all researchers in an equitable and timely manner. This requires a
      concerted effort throughout the NHS and consistent demand as well as financial
      support from researchers, particularly within industry. It is our view that the
      next 5-10 years will generate compelling evidence of the value of functional
      human tissue-based tests and recognition that more efficient use of residual or
      non-transplantable tissues and organs is an urgent priority for the development
      of new medicines.
FAU - Bunton, David
AU  - Bunton D
AD  - Biopta Ltd., Weipers Centre, Garscube Estate, Bearsden Road, Glasgow, UK.
      davidbunton@biopta.com
LA  - eng
PT  - Journal Article
DEP - 20100908
PL  - Netherlands
TA  - Cell Tissue Bank
JT  - Cell and tissue banking
JID - 100965121
SB  - IM
MH  - Animals
MH  - Biomedical Research
MH  - *Drug Discovery
MH  - Drug Industry
MH  - Humans
MH  - *Organ Specificity
MH  - United Kingdom
EDAT- 2010/09/09 06:00
MHDA- 2011/06/09 06:00
CRDT- 2010/09/09 06:00
PHST- 2010/07/27 00:00 [received]
PHST- 2010/07/29 00:00 [accepted]
PHST- 2010/09/09 06:00 [entrez]
PHST- 2010/09/09 06:00 [pubmed]
PHST- 2011/06/09 06:00 [medline]
AID - 10.1007/s10561-010-9213-5 [doi]
PST - ppublish
SO  - Cell Tissue Bank. 2011 Feb;12(1):31-2. doi: 10.1007/s10561-010-9213-5. Epub 2010 
      Sep 8.


PMID- 20824314
OWN - NLM
STAT- MEDLINE
DCOM- 20110301
LR  - 20211020
IS  - 1573-3599 (Electronic)
IS  - 1059-7700 (Linking)
VI  - 19
IP  - 6
DP  - 2010 Dec
TI  - Fairer sex: the ethics of determining gender for athletic eligibility: commentary
      on "Beyond the Caster Semenya controversy: the case of the use of genetics for
      gender testing in sport".
PG  - 549-50
LID - 10.1007/s10897-010-9322-0 [doi]
FAU - Caplan, Arthur L
AU  - Caplan AL
AD  - Center for Bioethics, University of Pennsylvania, Philadelphia, PA, USA.
      Caplan@mail.med.upenn.edu
LA  - eng
PT  - Comment
PT  - Journal Article
DEP - 20100908
PL  - United States
TA  - J Genet Couns
JT  - Journal of genetic counseling
JID - 9206865
SB  - IM
CON - J Genet Couns. 2010 Dec;19(6):545-8. PMID: 20824315
MH  - *Eligibility Determination
MH  - Female
MH  - *Genetic Testing
MH  - Humans
MH  - Male
MH  - *Sex Determination Analysis
MH  - *Sports
EDAT- 2010/09/09 06:00
MHDA- 2011/03/02 06:00
CRDT- 2010/09/09 06:00
PHST- 2010/08/04 00:00 [received]
PHST- 2010/08/11 00:00 [accepted]
PHST- 2010/09/09 06:00 [entrez]
PHST- 2010/09/09 06:00 [pubmed]
PHST- 2011/03/02 06:00 [medline]
AID - 10.1007/s10897-010-9322-0 [doi]
PST - ppublish
SO  - J Genet Couns. 2010 Dec;19(6):549-50. doi: 10.1007/s10897-010-9322-0. Epub 2010
      Sep 8.


PMID- 20823580
OWN - NLM
STAT- MEDLINE
DCOM- 20110722
LR  - 20190720
IS  - 1347-5215 (Electronic)
IS  - 0918-6158 (Linking)
VI  - 33
IP  - 9
DP  - 2010
TI  - Measurement of sialic acid content is insufficient to assess bioactivity of
      recombinant human erythropoietin.
PG  - 1596-9
AB  - Assessment of biological potency and its comparison with clinical effects are
      important in the quality control of therapeutic glycoproteins. Animal models are 
      usually used for evaluating bioactivity of these compounds. However, alternative 
      methods are required to simplify the bioassay and avoid ethical issues associated
      with animal studies. Negatively charged sialic acid residues are known to be
      critical for in vivo bioactivity of recombinant human erythropoietin (rhEPO). In 
      this study, we used capillary zone electrophoresis, a charge-based separation
      method, to estimate the sialic acid content for predicting in vivo bioactivity of
      rhEPO. In vivo bioactivities of rhEPO subfractions were measured and compared
      with sialylation levels. The results obtained indicated that in vivo bioactivity 
      of rhEPO is not simply correlated with the sialylation level, which suggests that
      it is difficult to predict biological potency from the sialic acid content alone.
      N-Glycan moieties as well as sialic acid residues may have a significant impact
      on in vivo bioactivity of rhEPO.
FAU - Yanagihara, Shigehiro
AU  - Yanagihara S
AD  - Bio Process Research and Development Laboratories, Production Division, Kyowa
      Hakko Kirin Co., Ltd., Gunma, Japan. shigehiro.yanagihara@kyowa-kirin.co.jp
FAU - Taniguchi, Yuya
AU  - Taniguchi Y
FAU - Hosono, Mareto
AU  - Hosono M
FAU - Yoshioka, Eiji
AU  - Yoshioka E
FAU - Ishikawa, Rika
AU  - Ishikawa R
FAU - Shimada, Yoshihiro
AU  - Shimada Y
FAU - Kadoya, Toshihiko
AU  - Kadoya T
FAU - Kutsukake, Kazuhiro
AU  - Kutsukake K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Recombinant Proteins)
RN  - 11096-26-7 (Erythropoietin)
RN  - GZP2782OP0 (N-Acetylneuraminic Acid)
SB  - IM
MH  - Animals
MH  - CHO Cells
MH  - Cricetinae
MH  - Cricetulus
MH  - Electrophoresis, Capillary
MH  - Erythropoietin/*analysis/*metabolism
MH  - Glycosylation
MH  - Humans
MH  - N-Acetylneuraminic Acid/*analysis/*metabolism
MH  - Recombinant Proteins
EDAT- 2010/09/09 06:00
MHDA- 2011/07/23 06:00
CRDT- 2010/09/09 06:00
PHST- 2010/09/09 06:00 [entrez]
PHST- 2010/09/09 06:00 [pubmed]
PHST- 2011/07/23 06:00 [medline]
AID - JST.JSTAGE/bpb/33.1596 [pii]
AID - 10.1248/bpb.33.1596 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2010;33(9):1596-9. doi: 10.1248/bpb.33.1596.


PMID- 20823439
OWN - NLM
STAT- MEDLINE
DCOM- 20100910
LR  - 20211020
IS  - 1538-3598 (Electronic)
IS  - 0098-7484 (Linking)
VI  - 304
IP  - 10
DP  - 2010 Sep 8
TI  - Exclusion of genetic information from the medical record: ethical and medical
      dilemmas.
PG  - 1120-1
LID - 10.1001/jama.2010.1303 [doi]
FAU - Klitzman, Robert
AU  - Klitzman R
AD  - Division of Psychiatry, Law, and Ethics, and HIV Center, Columbia University, New
      York, New York 10032, USA. rlk2@columbia.edu
LA  - eng
GR  - R01-HG002431-01/HG/NHGRI NIH HHS/United States
GR  - R01 HG002431-01/HG/NHGRI NIH HHS/United States
GR  - R01 HG002431/HG/NHGRI NIH HHS/United States
GR  - P20HG005535-01/HG/NHGRI NIH HHS/United States
GR  - P20 HG005535/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - JAMA
JT  - JAMA
JID - 7501160
SB  - IM
MH  - *Decision Making
MH  - Genetic Privacy/*ethics
MH  - *Genetic Testing
MH  - Health Care Reform
MH  - Humans
MH  - Medical Records Systems, Computerized/*standards
MH  - *Physicians
MH  - Prejudice
MH  - Truth Disclosure
MH  - United States
PMC - PMC3152485
MID - NIHMS314686
EDAT- 2010/09/09 06:00
MHDA- 2010/09/11 06:00
CRDT- 2010/09/09 06:00
PHST- 2010/09/09 06:00 [entrez]
PHST- 2010/09/09 06:00 [pubmed]
PHST- 2010/09/11 06:00 [medline]
AID - 304/10/1120 [pii]
AID - 10.1001/jama.2010.1303 [doi]
PST - ppublish
SO  - JAMA. 2010 Sep 8;304(10):1120-1. doi: 10.1001/jama.2010.1303.


PMID- 20823077
OWN - NLM
STAT- MEDLINE
DCOM- 20110217
LR  - 20220318
IS  - 1741-2889 (Electronic)
IS  - 1367-4935 (Linking)
VI  - 14
IP  - 4
DP  - 2010 Dec
TI  - Ethical dilemmas before and during anaesthetic induction of young children, as
      described by nurse anaesthetists.
PG  - 345-54
LID - 10.1177/1367493510379610 [doi]
AB  - Research on physicians', nurses' and enrolled nurses' experiences of ethical
      dilemmas have been conducted in many healthcare fields. The aim of this study was
      to elucidate ethical dilemmas before and during the induction of anaesthesia of
      children aged three to six years as described by nurse anaesthetists (NAs). Two
      group interviews with NAs were conducted where they were asked to describe
      ethically problematic situations. Three situations were chosen from a total of
      15: administration of anaesthesia to an already sleeping child, lack of
      information given to a child, and a child is anaesthetized against his/her will. 
      Conceivable and reasonable alternative options were identified and consequences
      of the different actions were presented. Finally the conflicts of value were
      discussed and commented on. The cases describe when a child's rights are given
      less weight and the child has little opportunity to participate in the decision
      making. However, parents and NAs acted in the best interest of the child.
      Analysing and reflecting on situations involving ethical dilemmas would enhance
      NAs critical thinking and guide NAs in their decision making when providing
      anaesthesia care.
FAU - Runeson, Ingrid
AU  - Runeson I
AD  - School of Health and Caring Sciences, Linnaeus University, Kalmar, Sweden.
      ingrid.runeson@lnu.se
FAU - Proczkowska-Bjorklund, Marie
AU  - Proczkowska-Bjorklund M
FAU - Idvall, Ewa
AU  - Idvall E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100907
PL  - England
TA  - J Child Health Care
JT  - Journal of child health care : for professionals working with children in the
      hospital and community
JID - 9806360
MH  - Anesthesia/ethics/*nursing
MH  - Child
MH  - Child, Preschool
MH  - *Decision Making
MH  - Female
MH  - Humans
MH  - Male
MH  - Nurse Anesthetists/*psychology
MH  - Nurse-Patient Relations/*ethics
MH  - Parent-Child Relations
MH  - Patient Participation
MH  - Patient Rights/ethics
MH  - Qualitative Research
EDAT- 2010/09/09 06:00
MHDA- 2011/02/18 06:00
CRDT- 2010/09/09 06:00
PHST- 2010/09/09 06:00 [entrez]
PHST- 2010/09/09 06:00 [pubmed]
PHST- 2011/02/18 06:00 [medline]
AID - 1367493510379610 [pii]
AID - 10.1177/1367493510379610 [doi]
PST - ppublish
SO  - J Child Health Care. 2010 Dec;14(4):345-54. doi: 10.1177/1367493510379610. Epub
      2010 Sep 7.


PMID- 20822970
OWN - NLM
STAT- MEDLINE
DCOM- 20110225
LR  - 20101203
IS  - 1167-1122 (Print)
IS  - 1167-1122 (Linking)
VI  - 20
IP  - 6
DP  - 2010 Nov-Dec
TI  - The evolution and use of skin explants: potential and limitations for
      dermatological research.
PG  - 671-84
LID - 10.1684/ejd.2010.1054 [doi]
AB  - Different models have been developed to understand the biology of skin or to test
      pharmaceutical/cosmetic products. These models can be in vitro models that
      possess advantages such as mono and co-culture models in 2D, which are very
      reproducible, or organotypic models (skin explant and reconstructed skin) that
      present a 3D organisation. Animal or human in vivo models allow studies that are 
      closer to reality. In virtuo models developed on computers control all known
      parameters and do not require animals. The major limitations of these models are 
      the lack of 3D structure for in vitro culture, the variability of results from
      organotypic models, ethical problems inherent to human and animal tests and the
      presence of numerous unknown parameters in in virtuo systems. Despite their
      limitations, skin explants seem to be an interesting model for studies. Skin
      explants may be kept from a few hours to 10-14 days on supports or directly in
      culture medium. These explants are generally cultivated at 37 degrees C, 5%
      CO(2), preferentially in serum-free conditions. Three basic techniques are used
      to characterise these models: histological stains, proliferation, apoptosis and
      cytotoxicity tests. Skin explants could be a very convenient model to study
      wound-healing, inflammation processes, autoimmune diseases, malignant
      transformation, stress, ageing, and to serve as screening tests.
FAU - Lebonvallet, Nicolas
AU  - Lebonvallet N
AD  - University of Brest, Faculty of Medicine and Health Sciences, Brest, France.
FAU - Jeanmaire, Christine
AU  - Jeanmaire C
FAU - Danoux, Louis
AU  - Danoux L
FAU - Sibille, Pierre
AU  - Sibille P
FAU - Pauly, Gilles
AU  - Pauly G
FAU - Misery, Laurent
AU  - Misery L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100907
PL  - France
TA  - Eur J Dermatol
JT  - European journal of dermatology : EJD
JID - 9206420
SB  - IM
MH  - Animals
MH  - *Biomedical Research
MH  - *Dermatology
MH  - Graft Survival
MH  - Humans
MH  - Models, Animal
MH  - Models, Biological
MH  - Skin Transplantation/*methods
MH  - Tissue Culture Techniques
EDAT- 2010/09/09 06:00
MHDA- 2011/02/26 06:00
CRDT- 2010/09/09 06:00
PHST- 2010/09/09 06:00 [entrez]
PHST- 2010/09/09 06:00 [pubmed]
PHST- 2011/02/26 06:00 [medline]
AID - ejd.2010.1054 [pii]
AID - 10.1684/ejd.2010.1054 [doi]
PST - ppublish
SO  - Eur J Dermatol. 2010 Nov-Dec;20(6):671-84. doi: 10.1684/ejd.2010.1054. Epub 2010 
      Sep 7.


PMID- 20822752
OWN - NLM
STAT- MEDLINE
DCOM- 20110504
LR  - 20141030
IS  - 1879-730X (Electronic)
IS  - 1879-7296 (Linking)
VI  - 127
IP  - 1
DP  - 2010 Mar
TI  - Laryngotracheal separation in neonatal brainstem dysfunction.
PG  - 23-6
LID - 10.1016/j.anorl.2010.02.006 [doi]
AB  - INTRODUCTION: Neonatal brainstem dysfunction (NBD) associates four symptoms of
      variable presence and intensity: suction-swallowing dysfunction, abnormal
      laryngeal sensitivity and motility, gastroesophageal reflux, and cardiac vagal
      overactivity. MATERIALS AND METHODS: We report three cases of severe NBD with
      chronic aspiration which required surgical management. Successive failures and
      clinical deterioration led us to perform laryngotracheal separation. The surgical
      procedure consisted in suturing the distal segment of the trachea to the cervical
      skin after complete closure of the larynx. RESULTS: After surgery, these children
      did not present any pulmonary infection and were allowed oral nutrition. However,
      oral communication was no longer possible. Although it is a theoretically
      reversible procedure, the decision is ethically difficult in children free of
      mental deficiency, because of the vocal loss and the unpredictable NBD outcome.
      CONCLUSION: Laryngotracheal separation may be recommended after multidisciplinary
      decision for severe chronic aspiration in the particular case of children
      presenting with NBD.
CI  - Copyright (c) 2010. Published by Elsevier Masson SAS.
FAU - Patron, G Cariou
AU  - Patron GC
AD  - ENT and Head and Neck Surgery Department, Robert Debre Hospital, Paris-VII
      University, Paris, France. gwcariou@yahoo.fr
FAU - Teissier, N
AU  - Teissier N
FAU - Malard, O
AU  - Malard O
FAU - Van Den Abbeele, T
AU  - Van Den Abbeele T
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20100324
PL  - France
TA  - Eur Ann Otorhinolaryngol Head Neck Dis
JT  - European annals of otorhinolaryngology, head and neck diseases
JID - 101531465
SB  - IM
MH  - Abnormalities, Multiple/physiopathology
MH  - Brain Diseases/*congenital/physiopathology
MH  - Brain Stem/*physiopathology
MH  - Child
MH  - Child, Preschool
MH  - Cooperative Behavior
MH  - Follow-Up Studies
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Interdisciplinary Communication
MH  - Larynx/*abnormalities/physiopathology/surgery
MH  - Male
MH  - Mutism/physiopathology/rehabilitation
MH  - Patient Care Team
MH  - Pneumonia, Aspiration/*congenital/physiopathology/surgery
MH  - Postoperative Complications/physiopathology/rehabilitation
MH  - Sign Language
MH  - Syncope/congenital/physiopathology
MH  - Trachea/*abnormalities/physiopathology/surgery
EDAT- 2010/09/09 06:00
MHDA- 2011/05/05 06:00
CRDT- 2010/09/09 06:00
PHST- 2010/09/09 06:00 [entrez]
PHST- 2010/09/09 06:00 [pubmed]
PHST- 2011/05/05 06:00 [medline]
AID - S1879-7296(10)00007-4 [pii]
AID - 10.1016/j.anorl.2010.02.006 [doi]
PST - ppublish
SO  - Eur Ann Otorhinolaryngol Head Neck Dis. 2010 Mar;127(1):23-6. doi:
      10.1016/j.anorl.2010.02.006. Epub 2010 Mar 24.


PMID- 20822649
OWN - NLM
STAT- MEDLINE
DCOM- 20101115
LR  - 20191027
IS  - 0256-9574 (Print)
VI  - 100
IP  - 9
DP  - 2010 Sep 7
TI  - Epidemiology of conventional cardiovascular risk factors among hypertensive
      subjects with normal and impaired fasting glucose.
PG  - 594-7
AB  - BACKGROUND: Impaired fasting or glucose tolerance and/or diabetes can occur with 
      hypertension, which theoretically predicts a worse cardiovascular risk profile,
      and consequently requires intensive cardiovascular risk management. OBJECTIVES:
      To characterise the frequency of the occurrence of conventional cardiovascular
      risk factors among hypertensive subjects with impaired fasting blood glucose.
      METHODS: We studied 120 hypertensive subjects and 80 age- and sex-matched
      normotensive controls. Relevant history, clinical examination, laboratory and
      other tests were undertaken. Body mass index was determined. Informed consent was
      obtained from all participants, and ethical approval was obtained. RESULTS: There
      was no statistically significant difference between the age and gender of the
      hypertensive subjects and the controls (55.1+/-10.83 v. 54.7+/-10.89 years,
      p=0.76). The serum fasting lipids were higher, but not statistically
      significantly, among the hypertensives than the controls (triglycerides
      1.23+/-0.50 v. 1.22+/-0.48, p=0.900; total cholesterol 4.51+/-1.52 v.
      4.38+/-0.84, p=0.842; LDL 2.51+/-1.41 v. 2.4+/-0.63, p=0.811, respectively). The 
      prevalence of impaired glucose tolerance among newly presenting hypertensive
      subjects was 30.0%. Hypertriglyceridaemia (38.9% v. 6.0%, p=0.038), hypo-HDL
      cholesterolaemia (52.7% v. 31.0%, p=0.028) and visceral obesity (52.8% v. 27.4%, 
      p=0.036) were statistically more prevalent among hypertensive subjects with
      impaired glucose tolerance than among those with normal glucose tolerance.
      CONCLUSION: The prevalence of impaired glucose tolerance among newly presenting
      hypertensive subject is very high, and they have more clusters of cardiovascular 
      risks than those without impaired glucose tolerance. The former therefore need
      intensive cardiovascular assessment and appropriate preventive and treatment
      modalities. Glucose parameters of newly presenting hypertensive subjects must be 
      determined to evaluate their cardiovascular risk profile.
FAU - Akintunde, A A
AU  - Akintunde AA
AD  - LAUTECH, Osogbo, Osun State, Nigeria. iakintunde2@yahoo.com
LA  - eng
PT  - Journal Article
DEP - 20100907
PL  - South Africa
TA  - S Afr Med J
JT  - South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
JID - 0404520
SB  - IM
MH  - Adult
MH  - Aged
MH  - Body Mass Index
MH  - Cardiovascular Diseases/complications/*epidemiology
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Hyperlipidemias/complications/epidemiology
MH  - Hypertension/*complications/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Obesity, Abdominal/complications/*epidemiology
MH  - Prediabetic State/complications/*epidemiology
MH  - Prevalence
MH  - Waist Circumference
MH  - Waist-Hip Ratio
EDAT- 2010/09/09 06:00
MHDA- 2010/11/16 06:00
CRDT- 2010/09/09 06:00
PHST- 2009/01/07 00:00 [received]
PHST- 2010/06/10 00:00 [accepted]
PHST- 2010/09/09 06:00 [entrez]
PHST- 2010/09/09 06:00 [pubmed]
PHST- 2010/11/16 06:00 [medline]
AID - 10.7196/samj.3180 [doi]
PST - epublish
SO  - S Afr Med J. 2010 Sep 7;100(9):594-7. doi: 10.7196/samj.3180.


PMID- 20822473
OWN - NLM
STAT- MEDLINE
DCOM- 20110811
LR  - 20161125
IS  - 1464-5165 (Electronic)
IS  - 0963-8288 (Linking)
VI  - 33
IP  - 11
DP  - 2011
TI  - Partners towards autonomy: risky choices and relational autonomy in
      rehabilitation care.
PG  - 961-7
LID - 10.3109/09638288.2010.515703 [doi]
AB  - PURPOSE: A common source of ethical challenge for health care professionals
      (HCPs) in rehabilitation is situations when patients wish to make risky choices
      not related or contrary to rehabilitation goals. We explore the potential
      contribution of a relational understanding of autonomy for orienting clinical
      practice when patients wish to enact choices with associated risks for the
      patient or others. METHOD: We provide a theoretical analysis that is oriented by 
      an examination of risk and a relational conception of autonomy, as relevant to
      rehabilitation care. We illustrate our analysis through the examination of a
      clinical case. RESULTS: Relational autonomy assumes that the patient, and the
      patient's decisional autonomy, is situated and shaped by relationships. From this
      perspective, HCPs can engage in a process of communication and deliberation with 
      the patient about the risky choices at issue, leading towards improved patient
      autonomy. CONCLUSIONS: Relational autonomy can contribute to understanding
      patients' risky choices and guiding HCPs as they partner with patients towards
      autonomy. Such an approach supports patient-centred rehabilitation care.
      Ultimately, as clinicians respond to a patient who wishes to enact a risky
      choice, they should aim for a partnership towards autonomy with the patient and
      family.
FAU - Hunt, Matthew R
AU  - Hunt MR
AD  - Centre for Research on Ethics (CREUM), University of Montreal, Montreal, Quebec, 
      Canada. 1matthew.hunt@gmail.com
FAU - Ells, Carolyn
AU  - Ells C
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100908
PL  - England
TA  - Disabil Rehabil
JT  - Disability and rehabilitation
JID - 9207179
SB  - IM
MH  - Aged
MH  - *Choice Behavior
MH  - Communication
MH  - Health Promotion
MH  - Humans
MH  - Male
MH  - *Personal Autonomy
MH  - Physician-Patient Relations
MH  - Professional-Patient Relations
MH  - *Rehabilitation
MH  - Risk Assessment
MH  - Risk-Taking
MH  - Stroke Rehabilitation
EDAT- 2010/09/09 06:00
MHDA- 2011/08/13 06:00
CRDT- 2010/09/09 06:00
PHST- 2010/09/09 06:00 [entrez]
PHST- 2010/09/09 06:00 [pubmed]
PHST- 2011/08/13 06:00 [medline]
AID - 10.3109/09638288.2010.515703 [doi]
PST - ppublish
SO  - Disabil Rehabil. 2011;33(11):961-7. doi: 10.3109/09638288.2010.515703. Epub 2010 
      Sep 8.


PMID- 20822335
OWN - NLM
STAT- MEDLINE
DCOM- 20110207
LR  - 20220408
IS  - 1476-4954 (Electronic)
IS  - 1476-4954 (Linking)
VI  - 23 Suppl 3
DP  - 2010 Oct
TI  - Shared decision-making in neonatology: an utopia or an attainable goal?
PG  - 56-8
LID - 10.3109/14767058.2010.509913 [doi]
AB  - Medical decision making is sometimes considered as a relatively simple process in
      which a decision may be made by the physician, by the patient, or by both patient
      and physician working together. There are three main models of decision
      making--paternalism, patient informed choice, and shared decision-making (SDM),
      having each one of these drawbacks and limitations. Historically, the most
      adopted one was the paternalism (strongly 'Doctor knows best'), where the
      professional made the decision based on what he/she considered to be as the
      patient's best interest, not necessarily contemplating patient's will and wishes.
      Currently, at the antipodes, the patient informed choice, where the patient makes
      his/her decision based on information received from the physician with no
      possible interference of professional's own preferences, seems to be the
      preferred relationship standard. SDM represents an intermediate approach between 
      the two above-mentioned opposite models, being a medical process that involves
      actively the doctor and the patient who both bring their own facts and
      preferences to reach an agreement on the decision on if, when and how to treat a 
      disease. This model, being characterized by elements pertaining to both the
      others, is gaining popularity in several medical and surgical scenarios whenever 
      a competent patient is able to actively participate into the decisional process. 
      On this basis can this model be implemented also in a Neonatology Intensive Care 
      Unit where little patients are--by nature--incompetent, being the
      diagnostic/therapeutic choices taken by parents? We focused on this complex item 
      considering four possible different scenarios and it seems to us that it could be
      possible to introduce such an approach, providing that parents' empowerment, a
      good physician's communication skill and consideration of all cultural,
      religious, economic, and ethic values of every single actor have been fairly
      taken into account.
FAU - D'Aloja, Ernesto
AU  - D'Aloja E
AD  - Forensic Science Department, Cagliari Teaching Hospital and University, SS 554
      Bivio Sestu, Monserrato. ernestodaloja@medicina.unica.it
FAU - Floris, Laura
AU  - Floris L
FAU - Muller, Mima
AU  - Muller M
FAU - Birocchi, Francesca
AU  - Birocchi F
FAU - Fanos, Vassilios
AU  - Fanos V
FAU - Paribello, Francesco
AU  - Paribello F
FAU - Demontis, Roberto
AU  - Demontis R
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Matern Fetal Neonatal Med
JT  - The journal of maternal-fetal & neonatal medicine : the official journal of the
      European Association of Perinatal Medicine, the Federation of Asia and Oceania
      Perinatal Societies, the International Society of Perinatal Obstetricians
JID - 101136916
SB  - IM
MH  - Communication
MH  - Decision Making/*physiology
MH  - Family Nursing/methods/trends
MH  - Goals
MH  - Humans
MH  - Infant, Newborn
MH  - Neonatology/*methods
MH  - *Professional-Family Relations
MH  - Utopias
EDAT- 2010/09/09 06:00
MHDA- 2011/02/08 06:00
CRDT- 2010/09/09 06:00
PHST- 2010/09/09 06:00 [entrez]
PHST- 2010/09/09 06:00 [pubmed]
PHST- 2011/02/08 06:00 [medline]
AID - 10.3109/14767058.2010.509913 [doi]
PST - ppublish
SO  - J Matern Fetal Neonatal Med. 2010 Oct;23 Suppl 3:56-8. doi:
      10.3109/14767058.2010.509913.


PMID- 20822325
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20190518
IS  - 0261-1929 (Print)
IS  - 0261-1929 (Linking)
VI  - 38
IP  - 4
DP  - 2010 Aug
TI  - Introducing ethical evaluation of the use of animals in experiments in the Near
      East.
PG  - 331-6
AB  - Turkey and Iran are two Near East countries that are developing ethical
      regulation systems for animal experiments, following significant developments in 
      this field in neighbouring Europe. In Turkey, legislation was passed between 2004
      and 2006 to mandate ethical review of experiments which involve the use of
      laboratory animals. Today, one central and 73 local ethics committees exist, to
      evaluate the use of animals and the numbers of animals used, and to consider
      applications for animal experimentation. In Iran, Animal Ethics Committees (AECs)
      were established in 2004 in approximately 50 medical universities. The objective 
      of the AECs is to preserve animal welfare and ethics, taking into account Islamic
      principles, and to be cognisant of world trends for the improvement of laboratory
      animal welfare. The recent establishment of animal ethical review in the Near
      East could benefit from experiences in Western countries, in their evolution
      toward high standards of experimental animal ethics.
CI  - 2010 FRAME.
FAU - Izmirli, Serdar
AU  - Izmirli S
AD  - Department of History of Veterinary Medicine and Deontology, Selcuk University,
      Konya, Turkey.
FAU - Aldavood, S Javid
AU  - Aldavood SJ
FAU - Yasar, Askin
AU  - Yasar A
FAU - Phillips, Clive J C
AU  - Phillips CJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - Altern Lab Anim
JT  - Alternatives to laboratory animals : ATLA
JID - 8110074
SB  - IM
MH  - Animal Experimentation/*ethics/standards
MH  - Animal Testing Alternatives/*ethics/standards
MH  - Animal Welfare/ethics/standards
MH  - Animals
MH  - Iran
MH  - Islam
MH  - Middle East
MH  - Turkey
EDAT- 2010/09/09 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/09/09 06:00
PHST- 2010/09/09 06:00 [entrez]
PHST- 2010/09/09 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - 10.1177/026119291003800410 [doi]
PST - ppublish
SO  - Altern Lab Anim. 2010 Aug;38(4):331-6. doi: 10.1177/026119291003800410.


PMID- 20822044
OWN - NLM
STAT- MEDLINE
DCOM- 20100921
LR  - 20100908
IS  - 0040-7453 (Print)
IS  - 0040-7453 (Linking)
VI  - 135
IP  - 16
DP  - 2010 Aug 15
TI  - [Ethics in the practice: a lame collie, reason for euthanasia?].
PG  - 612-4
FAU - van Herten, Joost
AU  - van Herten J
AD  - KNMVD. j.van.herten@knmvd.nl
LA  - dut
PT  - Case Reports
PT  - Journal Article
TT  - Ethiek in de praktijk: de verlamde collie, reden tot euthanasie?
PL  - Netherlands
TA  - Tijdschr Diergeneeskd
JT  - Tijdschrift voor diergeneeskunde
JID - 0031550
SB  - IM
MH  - Animal Welfare/ethics/legislation & jurisprudence
MH  - Animals
MH  - Dogs
MH  - Euthanasia, Animal/*ethics/*legislation & jurisprudence
MH  - Humans
MH  - Lameness, Animal/physiopathology
MH  - Male
MH  - Netherlands
MH  - Quality of Life
MH  - Veterinarians/*ethics/*psychology
MH  - Veterinary Medicine/*ethics/standards
EDAT- 2010/09/09 06:00
MHDA- 2010/09/23 06:00
CRDT- 2010/09/09 06:00
PHST- 2010/09/09 06:00 [entrez]
PHST- 2010/09/09 06:00 [pubmed]
PHST- 2010/09/23 06:00 [medline]
PST - ppublish
SO  - Tijdschr Diergeneeskd. 2010 Aug 15;135(16):612-4.


PMID- 20821901
OWN - HMD
STAT- MEDLINE
DCOM- 20101230
LR  - 20191111
IS  - 1072-4745 (Print)
IS  - 1072-4745 (Linking)
VI  - 17
IP  - 3
DP  - 2010
TI  - A magic bullet for the "African" mother? Neo-Imperial reproductive futurism and
      the pharmaceutical "solution" to the HIV/AIDS Crisis.
PG  - 349-78
AB  - On the basis of a close reading of popular and medical texts which address a
      debate over the ethics of clinical drug trials funded by the United States and
      designed mainly for sub-Saharan Africa, I argue that international public health 
      discourse about infant HIV infection in that region reflects and legitimates a
      neo-imperialist, anti-reproductive justice ideology. Participants share a
      fetal-centered logic that US-funded biomedicine must shoulder the burden of
      rescuing sub-Saharan Africa from itself by using the bodies of HIV-positive
      pregnant women to transmit biomedicine's magic bullet-antiretroviral drugs-to the
      next generation. The survival of the fetus, disguised as the well-being of the
      HIV-positive woman and accomplished by the magic of biomedical research, becomes 
      the survival of a region otherwise doomed by its present state of economic,
      political, and medical incapacity. This version of what queer theorist Lee
      Edelman (2004, No Future: Queer Theory and the Death Drive) calls "reproductive
      futurism" redounds to the benefit of the more explicitly women-hating and
      nationalist ideologies of still-powerful right-wing movements against
      reproductive and sexual rights.
FAU - Booth, Karen M
AU  - Booth KM
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - Soc Polit
JT  - Social politics
JID - 101520948
RN  - 0 (Antirheumatic Agents)
RN  - 0 (Pharmaceutical Solutions)
MH  - *Acquired Immunodeficiency Syndrome/economics/ethnology/history/psychology
MH  - Africa South of the Sahara/ethnology
MH  - *Antirheumatic Agents/economics/history
MH  - *Clinical Trials as Topic/economics/history/legislation &
      jurisprudence/psychology
MH  - Ethics, Medical/education/history
MH  - *Ethics, Pharmacy/education/history
MH  - Female
MH  - *HIV
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Patient Participation/economics/history/legislation & jurisprudence/psychology
MH  - *Pharmaceutical Solutions/economics/history
MH  - Politics
MH  - Pregnancy
MH  - Public Health/economics/education/history/legislation & jurisprudence
MH  - United States/ethnology
MH  - *Women's Health/ethnology/history
EDAT- 2010/09/09 06:00
MHDA- 2010/12/31 06:00
CRDT- 2010/09/09 06:00
PHST- 2010/09/09 06:00 [entrez]
PHST- 2010/09/09 06:00 [pubmed]
PHST- 2010/12/31 06:00 [medline]
AID - 10.1093/sp/jxq012 [doi]
PST - ppublish
SO  - Soc Polit. 2010;17(3):349-78. doi: 10.1093/sp/jxq012.


PMID- 20821814
OWN - NLM
STAT- MEDLINE
DCOM- 20110216
LR  - 20181201
IS  - 1099-0798 (Electronic)
IS  - 0735-3936 (Linking)
VI  - 28
IP  - 5
DP  - 2010 Sep-Oct
TI  - Empathy or objectivity: The forensic examiner's dilemma?
PG  - 585-602
LID - 10.1002/bsl.953 [doi]
AB  - Examiners are ethically bound to manage personal biases that may infect their
      expert opinions. Empathy-related issues that lead to bias in forensic assessment 
      of adjudicative competence arise in evaluation interactions with defendants
      (therapeutic empathy) and from examiners' personal views of issues that these
      assessments address (empathy-bias). This article first summarizes flexible
      adjudicative competence legal standards that invite bias by forensic experts.
      Then, after reviewing the therapeutic empathy issue, the article examines
      empathy-bias and its effects on the development of expert opinions. The authors
      assert that, properly managed, the often assumed dilemma between empathy and
      objectivity is a false one. Using case law, research psychology, and professional
      guidelines, the authors first emphasize that examiners must actively generate
      plausible alternative explanations of evaluation data as they form their
      opinions, not afterwards. Then the authors present a practical model to help
      experts develop opinions that best explain the data while minimizing
      empathy-bias.
CI  - Copyright (c) 2010 John Wiley & Sons, Ltd.
FAU - Shuman, Daniel W
AU  - Shuman DW
AD  - Southern Methodist University, Dallas, TX 75275-0116, USA. dshuman@mail.smu.edu
FAU - Zervopoulos, John A
AU  - Zervopoulos JA
LA  - eng
PT  - Journal Article
PT  - Legal Case
PL  - United States
TA  - Behav Sci Law
JT  - Behavioral sciences & the law
JID - 8404861
SB  - IM
MH  - Criminals/psychology
MH  - *Empathy
MH  - Forensic Psychiatry/*standards
MH  - Humans
MH  - Mental Competency/*legislation & jurisprudence/standards
MH  - Prejudice
MH  - United States
EDAT- 2010/09/08 06:00
MHDA- 2011/02/17 06:00
CRDT- 2010/09/08 06:00
PHST- 2010/09/08 06:00 [entrez]
PHST- 2010/09/08 06:00 [pubmed]
PHST- 2011/02/17 06:00 [medline]
AID - 10.1002/bsl.953 [doi]
PST - ppublish
SO  - Behav Sci Law. 2010 Sep-Oct;28(5):585-602. doi: 10.1002/bsl.953.


PMID- 20821198
OWN - NLM
STAT- MEDLINE
DCOM- 20101215
LR  - 20211020
IS  - 1432-1041 (Electronic)
IS  - 0031-6970 (Linking)
VI  - 66
IP  - 11
DP  - 2010 Nov
TI  - Paediatric investigation plans for pain: painfully slow!
PG  - 1091-7
LID - 10.1007/s00228-010-0886-2 [doi]
AB  - PURPOSE: To examine the early impact of the Paediatric Regulation, which entered 
      into force in Europe on 27 January 2007, on the development of pharmaceutical
      drugs in the therapeutic field of pain submitted to the Paediatric Committee
      (PDCO) and to the European Medicines Agency (EMA). METHODS: Paediatric
      Investigations Plans (PIPs) submitted with a Decision (outcome) reached between
      September 2007 and March 2010 were included in the analysis. RESULTS: Of the 17
      Paediatric Investigation Plans submitted, 14 have resulted in an EMA Decision, 3 
      were withdrawn by the applicants, 8 were granted a full waiver from development, 
      and 1 resulted in a negative opinion. Decisions as issued included 15 clinical
      trials, with at least 1,282 children to be recruited into studies across five
      different products. Neonates were included in four of the products. CONCLUSIONS: 
      The small number of submissions indicates a lack of new drugs being developed for
      the management of pain. Ethical concerns that too many vulnerable children will
      be recruited into clinical trials must be balanced against limiting the number of
      off-label prescribing and obtaining age-appropriate information on paediatric
      use. Now is an opportune time for clinicians, academics, learned societies and
      industry to collaborate for the benefit of children in pain.
FAU - Davies, Elin H
AU  - Davies EH
AD  - Institute of Child Health, University College London, 30 Guilford Street, London,
      WC1N 1EH, UK.
FAU - Ollivier, Cecile M
AU  - Ollivier CM
FAU - Saint Raymond, Agnes
AU  - Saint Raymond A
LA  - eng
PT  - Journal Article
DEP - 20100907
PL  - Germany
TA  - Eur J Clin Pharmacol
JT  - European journal of clinical pharmacology
JID - 1256165
RN  - 0 (Analgesics)
SB  - IM
MH  - Adolescent
MH  - Advisory Committees
MH  - *Analgesics/chemistry/pharmacology/therapeutic use
MH  - Chemistry, Pharmaceutical
MH  - Child
MH  - Child, Preschool
MH  - Drug Industry/*legislation & jurisprudence
MH  - *European Union
MH  - Humans
MH  - *Legislation, Drug
MH  - Legislation, Medical
MH  - Marketing of Health Services/legislation & jurisprudence
MH  - Pain/*drug therapy
MH  - Pediatrics/*legislation & jurisprudence/standards
EDAT- 2010/09/08 06:00
MHDA- 2010/12/16 06:00
CRDT- 2010/09/08 06:00
PHST- 2010/04/28 00:00 [received]
PHST- 2010/08/11 00:00 [accepted]
PHST- 2010/09/08 06:00 [entrez]
PHST- 2010/09/08 06:00 [pubmed]
PHST- 2010/12/16 06:00 [medline]
AID - 10.1007/s00228-010-0886-2 [doi]
PST - ppublish
SO  - Eur J Clin Pharmacol. 2010 Nov;66(11):1091-7. doi: 10.1007/s00228-010-0886-2.
      Epub 2010 Sep 7.


PMID- 20820150
OWN - NLM
STAT- MEDLINE
DCOM- 20110201
LR  - 20131121
IS  - 1827-1596 (Electronic)
IS  - 0375-9393 (Linking)
VI  - 76
IP  - 9
DP  - 2010 Sep
TI  - Propofol injection pain: is it still an issue? The effect of premedication.
PG  - 720-4
AB  - BACKGROUND: The use of propofol often results in pain upon injection. Various
      strategies can be used to reduce this pain, ranging from the administration of
      analgesics to modification of the propofol emulsion. However, basic premedication
      protocol aimed at peri- and postoperative pain reduction could also sufficiently 
      reduce propofol injection pain, rendering other special interventions redundant. 
      METHODS: With the approval of the Local Ethics Committee of the Erasmus Medical
      Centre Rotterdam, and after obtaining written informed consent from each patient 
      included, 209 surgical patients (ASA physical status I-III) were randomized in a 
      double-blind manner to receive premedication consisting of 7.5 mg midazolam, 50
      mg diclofenac and 1000 mg acetaminophen (all orally administered) and fentanyl
      (intravenously administered) or placebo medication the hour before surgery. In
      both groups a mixture of 40 mL propofol 1% with 2 mL lidocaine 1% was used to
      induce anesthesia. Pain scores were assessed using a verbal analog scale (VAS)
      ranging from 0-10. RESULTS: The premedication group was found to have
      significantly less pain upon injection of propofol (median VAS 0+/-0-2)
      (median+/-interquartile range) when compared to the control group (median VAS
      1.5+/-0-4; P=0.001). In addition, more patients in the premedication group
      experienced no pain at all. This effect was still present one hour after
      extubation. CONCLUSION: Even when injection pain is reduced, the use of a
      premedication regimen clearly has additional value with respect to the patients' 
      experience. Considering the low VAS scores observed overall, it might be
      worthwhile to reserve additional injection pain-reducing interventions for
      individual patients rather than adding them as a component of standard practice.
FAU - Dedic, A
AU  - Dedic A
AD  - Department of Anesthesiology, Erasmus Medical Centre, Rotterdam, the Netherlands.
FAU - Adam, S
AU  - Adam S
FAU - Gommers, D
AU  - Gommers D
FAU - Van Bommel, J
AU  - Van Bommel J
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20100628
PL  - Italy
TA  - Minerva Anestesiol
JT  - Minerva anestesiologica
JID - 0375272
RN  - 0 (Anesthetics, Intravenous)
RN  - YI7VU623SF (Propofol)
SB  - IM
CIN - Minerva Anestesiol. 2010 Sep;76(9):690-1. PMID: 20820145
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Anesthetics, Intravenous/administration & dosage/*adverse effects
MH  - Double-Blind Method
MH  - Humans
MH  - Middle Aged
MH  - Pain/*chemically induced/*prevention & control
MH  - *Preanesthetic Medication
MH  - Propofol/administration & dosage/*adverse effects
MH  - Young Adult
EDAT- 2010/09/08 06:00
MHDA- 2011/02/02 06:00
CRDT- 2010/09/08 06:00
PHST- 2010/09/08 06:00 [entrez]
PHST- 2010/09/08 06:00 [pubmed]
PHST- 2011/02/02 06:00 [medline]
AID - R02105953 [pii]
PST - ppublish
SO  - Minerva Anestesiol. 2010 Sep;76(9):720-4. Epub 2010 Jun 28.


PMID- 20820118
OWN - NLM
STAT- MEDLINE
DCOM- 20101124
LR  - 20151119
IS  - 2005-3673 (Print)
IS  - 2005-3673 (Linking)
VI  - 40
IP  - 4
DP  - 2010 Aug
TI  - [Educational needs assessment on research ethics among nursing researchers].
PG  - 515-23
LID - 10.4040/jkan.2010.40.4.515 [doi]
AB  - PURPOSE: This study aimed to investigate the educational needs of research ethics
      among nursing researchers. METHODS: Convenience sample of 161 nursing professors 
      and 262 master or doctoral nursing students participated in the study. Data was
      collected with self-reported questionnaire from June to August 2009, and analyzed
      with descriptive statistics using SPSS WIN (version 14.0). RESULTS: Among 161
      nursing professors, about 31.7% has educated nursing ethics in the postgraduate
      course. The most common course was nursing research or methodology (62.7%), and
      median education time was 2 hr. Areas that showed difficulty in understanding was
      the conflict of interest and plagiarism for professors and falsification and
      fabrication for graduate students. Average knowledge on the research ethics was
      75.4 points for professors and 61.6 points for students based on the 100 points. 
      CONCLUSION: Educational needs of research ethics among nursing professors and
      students in the postgraduate course was high. We recommend both basic and
      advanced research ethics educational programs for the nursing researchers. The
      basic course should be at least 6 hr and include various cases and something to
      discuss.
FAU - Jeong, Ihn Sook
AU  - Jeong IS
AD  - College of Nursing, Pusan National University, Busan, Korea. jeongis@pusan.ac.kr
FAU - Gu, Mee Ock
AU  - Gu MO
FAU - Kim, Keum Soon
AU  - Kim KS
FAU - Lee, Kwang Ja
AU  - Lee KJ
FAU - Yang, Soo
AU  - Yang S
LA  - kor
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Korea (South)
TA  - J Korean Acad Nurs
JT  - Journal of Korean Academy of Nursing
JID - 101488689
SB  - IM
MH  - Adult
MH  - Ethics, Nursing/*education
MH  - *Faculty, Nursing
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Needs Assessment
MH  - Nursing Research/*education
MH  - Surveys and Questionnaires
EDAT- 2010/09/08 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/09/08 06:00
PHST- 2010/09/08 06:00 [entrez]
PHST- 2010/09/08 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 201008515 [pii]
AID - 10.4040/jkan.2010.40.4.515 [doi]
PST - ppublish
SO  - J Korean Acad Nurs. 2010 Aug;40(4):515-23. doi: 10.4040/jkan.2010.40.4.515.


PMID- 20819846
OWN - NLM
STAT- MEDLINE
DCOM- 20110412
LR  - 20101208
IS  - 1477-030X (Electronic)
IS  - 0269-2163 (Linking)
VI  - 24
IP  - 8
DP  - 2010 Dec
TI  - End-of-life practices in palliative care: a cross sectional survey of physician
      members of the German Society for Palliative Medicine.
PG  - 820-7
LID - 10.1177/0269216310381663 [doi]
AB  - OBJECTIVES: To elicit types and frequencies of end-of-life practices by physician
      members of the German Society for Palliative Medicine. To analyse associations
      between characteristics of physicians and patients and end-of-life practices with
      intended hastening of death. DESIGN: Cross-sectional postal survey. MAIN OUTCOME 
      MEASURES: Types and frequencies of end-of-life practices with foreseeable or
      intended hastening of patients' death. Association between end-of-life practices 
      with hastening of death and predefined characteristics of physicians and
      patients. RESULTS: Nine hundred and one physicians participated in the study
      (response rate: 55.8%). There was alleviation of symptoms in 78.1% and limitation
      of medical treatment with possible life shortening in 69.1% of cases. In 10 cases
      medication had been administered by the physician (N = 9) or the patient (N = 1) 
      with the intention to hasten death. Patients' best interest and avoidance of
      possible harm to the patient were reported as reasons for non-involvement of
      competent patients in decision making. Physicians with added qualification in
      palliative medicine significantly less frequently reported end-of-life practices 
      with intended hastening of death (p = 0.003). CONCLUSION: Physician members of
      the German Society for Palliative Medicine perform a broad spectrum of
      end-of-life practices including intended hastening of death. The findings on
      patients' non-involvement in decision making warrant further empirical-ethical
      analysis.
FAU - Schildmann, Jan
AU  - Schildmann J
AD  - Institute for Medical Ethics and History of Medicine, Ruhr-University Bochum,
      Malakowturm-Markstr. 258a, 44799 Bochum, Germany. jan.schildmann@rub.de
FAU - Hoetzel, Julia
AU  - Hoetzel J
FAU - Mueller-Busch, Christof
AU  - Mueller-Busch C
FAU - Vollmann, Jochen
AU  - Vollmann J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100906
PL  - England
TA  - Palliat Med
JT  - Palliative medicine
JID - 8704926
SB  - IM
CIN - Palliat Med. 2010 Dec;24(8):751-2. PMID: 21139046
MH  - Adolescent
MH  - Adult
MH  - Age Distribution
MH  - Aged
MH  - Aged, 80 and over
MH  - *Attitude of Health Personnel
MH  - Attitude to Death
MH  - Child
MH  - Child, Preschool
MH  - Decision Making
MH  - Epidemiologic Methods
MH  - Euthanasia, Active/psychology/*statistics & numerical data
MH  - Female
MH  - Germany
MH  - Humans
MH  - Infant
MH  - Male
MH  - Middle Aged
MH  - Palliative Care/*methods/psychology
MH  - Professional Practice/statistics & numerical data
MH  - Sex Distribution
MH  - Young Adult
EDAT- 2010/09/08 06:00
MHDA- 2011/04/13 06:00
CRDT- 2010/09/08 06:00
PHST- 2010/09/08 06:00 [entrez]
PHST- 2010/09/08 06:00 [pubmed]
PHST- 2011/04/13 06:00 [medline]
AID - 0269216310381663 [pii]
AID - 10.1177/0269216310381663 [doi]
PST - ppublish
SO  - Palliat Med. 2010 Dec;24(8):820-7. doi: 10.1177/0269216310381663. Epub 2010 Sep
      6.


PMID- 20819716
OWN - NLM
STAT- MEDLINE
DCOM- 20101222
LR  - 20100907
IS  - 0767-0974 (Print)
IS  - 0767-0974 (Linking)
VI  - 26
IP  - 8-9
DP  - 2010 Aug-Sep
TI  - [The history of the clinical research settlement in French hospitals].
PG  - 768-71
LID - 10.1051/medsci/2010268-9768 [doi]
AB  - Since 1992, French clinical research centers (CRC) allow physicians and
      researchers to develop clinical and therapeutic research on humans in public
      hospitals. Created by the National institute for health and medical research
      (Inserm) in collaboration with public hospitals, their history give us the
      opportunity to describe the complex interactions in France between fundamental
      and clinical research. Why does therapeutic research need CRC? What can be done
      in these structures that cannot be done in hospital wards? Medical research is an
      hybrid practice torn between fundamental and clinical methodologies and
      objectives. To solve this tension, CRC are << trading zones >> (Galison, 1997):
      intermediate areas where physicians and researchers can develop -common languages
      and methodologies to coordinate their practices and objectives. CRC also become
      essential to support the ethical, legal and administrative constraints of
      therapeutic research. double dagger.
FAU - Moutaud, Baptiste
AU  - Moutaud B
AD  - Universite Paris Descartes, Ecole des hautes Etudes en Sciences sociales, Paris, 
      France. moutaud.baptiste@club-internet.fr
LA  - fre
PT  - English Abstract
PT  - Historical Article
PT  - Journal Article
TT  - L'implantation de la recherche clinique a l'hopital en France : histoire de la
      creation des centres d'investigation clinique.
PL  - France
TA  - Med Sci (Paris)
JT  - Medecine sciences : M/S
JID - 8710980
SB  - IM
MH  - Academies and Institutes/history
MH  - Biomedical Research/*history
MH  - France
MH  - History, 20th Century
MH  - Hospitals, Public/*history
MH  - Humans
MH  - Paris
MH  - Physicians
MH  - Research Personnel
MH  - Therapeutic Human Experimentation/history
EDAT- 2010/09/08 06:00
MHDA- 2010/12/24 06:00
CRDT- 2010/09/08 06:00
PHST- 2010/09/08 06:00 [entrez]
PHST- 2010/09/08 06:00 [pubmed]
PHST- 2010/12/24 06:00 [medline]
AID - 00/00/0F/BC/ [pii]
AID - 10.1051/medsci/2010268-9768 [doi]
PST - ppublish
SO  - Med Sci (Paris). 2010 Aug-Sep;26(8-9):768-71. doi: 10.1051/medsci/2010268-9768.


PMID- 20819252
OWN - NLM
STAT- MEDLINE
DCOM- 20101220
LR  - 20100907
IS  - 1815-7920 (Electronic)
IS  - 1027-3719 (Linking)
VI  - 14
IP  - 9
DP  - 2010 Sep
TI  - Surveillance for MDR-TB: is there an obligation to ensure treatment for
      individuals identified with MDR-TB?
PG  - 1094-6
AB  - This article raises ethical issues that result if individuals, during the course 
      of research to measure the prevalence of drug-resistant tuberculosis, are
      identified with the disease but are not provided with or referred for appropriate
      treatment. It draws attention to and applauds recently published World Health
      Organization guidelines on the subject. Questions posed are: 1) Should treatment 
      be provided for individuals identified through surveillance projects for MDR-TB, 
      whatever their purpose (specific research or 'routine' national prevalence
      studies)? 2) If treatment availability is a problem, who is responsible for
      assuring this?
FAU - Edginton, M E
AU  - Edginton ME
AD  - Ethics Advisory Group, International Union Against Tuberculosis and Lung Disease,
      Paris, France. maryhodkinson@gmail.com
FAU - Miller, D L
AU  - Miller DL
FAU - Burney, P
AU  - Burney P
FAU - El Sony, A I
AU  - El Sony AI
FAU - Lwilla, F I
AU  - Lwilla FI
FAU - O'Brien, R
AU  - O'Brien R
FAU - Roldan, M B
AU  - Roldan MB
FAU - Roldan, A
AU  - Roldan A
FAU - Srinath, S
AU  - Srinath S
LA  - eng
PT  - Journal Article
PL  - France
TA  - Int J Tuberc Lung Dis
JT  - The international journal of tuberculosis and lung disease : the official journal
      of the International Union against Tuberculosis and Lung Disease
JID - 9706389
RN  - 0 (Antitubercular Agents)
SB  - IM
MH  - Antitubercular Agents/supply & distribution/therapeutic use
MH  - *Ethics, Medical
MH  - Humans
MH  - Population Surveillance/*methods
MH  - Prevalence
MH  - Tuberculosis, Multidrug-Resistant/diagnosis/*drug therapy/epidemiology
MH  - World Health Organization
EDAT- 2010/09/08 06:00
MHDA- 2010/12/21 06:00
CRDT- 2010/09/08 06:00
PHST- 2010/09/08 06:00 [entrez]
PHST- 2010/09/08 06:00 [pubmed]
PHST- 2010/12/21 06:00 [medline]
PST - ppublish
SO  - Int J Tuberc Lung Dis. 2010 Sep;14(9):1094-6.


PMID- 20819136
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20181201
IS  - 1365-2842 (Electronic)
IS  - 0305-182X (Linking)
VI  - 38
IP  - 4
DP  - 2011 Apr
TI  - Attitudes of final-year dental students to bleaching of vital and non-vital teeth
      in Cardiff, Cork, and Malmo.
PG  - 263-9
LID - 10.1111/j.1365-2842.2010.02155.x [doi]
AB  - The aim of this study was to determine attitudes of final-year dental students in
      Cardiff, Cork and Malmo towards tooth whitening. Following receipt of ethical
      approval, pre-piloted questionnaires were distributed to final-year dental
      students in Cork, Cardiff, and Malmo as close as possible to graduation. The
      questionnaire sought information relating to various opinions and attitudes
      towards the use of bleaching techniques including safety of bleaching, confidence
      in the provision of bleaching, recommendations to patients, teaching received,
      awareness of restrictions on the use of bleaching products and management of
      simulated clinical scenarios. Eighty three per cent (n = 116) of questionnaires
      were returned. Cork dental students had the most didactic teaching (2-h vital,
      1-h non-vital bleaching) compared to Cardiff or Malmo students (0 h each). More
      Cork students regarded bleaching as safe (76%, n = 28) than Cardiff (70%, n = 32)
      or Malmo (36%, n = 12) students. More than 50% of Cork students feel they know
      enough about bleaching to provide it in practice, significantly more than Cardiff
      (< 25%) or Malmo (< 25%) students. The majority of students would provide vital
      bleaching after qualification (100% (n = 37) Cork; 82% (n = 27) Malmo; 76% (n =
      35) Cardiff). In simulated clinical scenarios, more Cork students would propose
      bleaching treatments (89%n = 33) than Malmo (64%n = 21) or Cardiff (48%n= 22)
      students. Variations exist in the attitudes and approaches of three European
      dental schools towards bleaching. Dental students need to be best prepared to
      meet the needs of their future patients.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Hatherell, S
AU  - Hatherell S
AD  - School of Dentistry, Cardiff University Tissue Engineering & Reparative
      Dentistry, School of Dentistry, Cardiff University, Cardiff, UK.
FAU - Lynch, C D
AU  - Lynch CD
FAU - Burke, F M
AU  - Burke FM
FAU - Ericson, D
AU  - Ericson D
FAU - Gilmour, A S M
AU  - Gilmour AS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
DEP - 20100901
PL  - England
TA  - J Oral Rehabil
JT  - Journal of oral rehabilitation
JID - 0433604
RN  - 0 (Peroxides)
RN  - 0 (Tooth Bleaching Agents)
RN  - 31PZ2VAU81 (Carbamide Peroxide)
RN  - 8W8T17847W (Urea)
RN  - BBX060AN9V (Hydrogen Peroxide)
SB  - IM
MH  - *Attitude of Health Personnel
MH  - *Attitude to Health
MH  - Carbamide Peroxide
MH  - Clinical Competence
MH  - Dental Offices
MH  - Drug and Narcotic Control
MH  - Education, Dental
MH  - Humans
MH  - Hydrogen Peroxide/therapeutic use
MH  - Ireland
MH  - Patient Education as Topic
MH  - Peroxides/therapeutic use
MH  - Practice Patterns, Dentists'
MH  - Safety
MH  - Self Administration
MH  - Self Concept
MH  - Students, Dental/*psychology
MH  - Sweden
MH  - Tooth/drug effects
MH  - Tooth Bleaching/instrumentation/*methods
MH  - Tooth Bleaching Agents/therapeutic use
MH  - Tooth Discoloration/therapy
MH  - Tooth, Nonvital/pathology
MH  - Urea/analogs & derivatives/therapeutic use
MH  - Wales
EDAT- 2010/09/08 06:00
MHDA- 2011/07/27 06:00
CRDT- 2010/09/08 06:00
PHST- 2010/09/08 06:00 [entrez]
PHST- 2010/09/08 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
AID - JOR2155 [pii]
AID - 10.1111/j.1365-2842.2010.02155.x [doi]
PST - ppublish
SO  - J Oral Rehabil. 2011 Apr;38(4):263-9. doi: 10.1111/j.1365-2842.2010.02155.x. Epub
      2010 Sep 1.


PMID- 20818842
OWN - NLM
STAT- MEDLINE
DCOM- 20110118
LR  - 20100907
IS  - 1445-6354 (Electronic)
IS  - 1445-6354 (Linking)
VI  - 10
IP  - 3
DP  - 2010 Jul-Sep
TI  - 'Even if we get one back here, it's worth it...': evaluation of an Australian
      Remote Area Health Placement Program.
PG  - 1546
AB  - INTRODUCTION: In 2006 the Kimberley Remote Area Health Placement Program
      (hereinafter the 'Program') was established at the University of Notre Dame's
      School of Medicine (Fremantle campus, Western Australia). The Program was
      developed as one of the strategies to achieve the School of Medicine's mission to
      graduate knowledgeable, skillful, dutiful and ethical doctors who will want to
      work in Australian areas of unmet need. The Program aims to immerse medical
      students in non-clinical settings to provide them with opportunities to learn
      life skills required for remote area living, and to introduce them to the myriad 
      of socio-cultural, geographic, climatic and economic factors that impact on the
      health and wellbeing of remote area residents. To meet these objectives, the
      School organizes for students to live with, and do useful non-clinical work for, 
      a host community or organization for up to one week. In 2008 the Program was
      evaluated to explore and assess its immediate and potential future benefits and
      limitations as perceived by Kimberley residents. This paper reports on the
      evaluation's findings via Kimberley-based narratives and raises some issues that 
      are essential to training and retaining a 'bloody good doctor...' in a remote
      Australian setting. METHODS: Using a mix of qualitative, ethnographic methods,
      the Program was evaluated by an independent researcher during four weeks of field
      research in late 2008. The methods included a survey, structured and unstructured
      interviewing and participant observation to elicit data. Thirty-three formal
      interviews of at least one hour's duration were conducted. Data were also
      collected via 15 informal discussions. Both formal and conservational
      interactions occurred in a range of town-based and more remote settings. RESULTS:
      The majority of persons consulted generally highlighted the Program's benefits.
      The reasons for this positive evaluation varied, but a common thread was that
      exposure to the Kimberley introduced the students to local life, a quality that
      had the potential to result in a medical student returning as a qualified doctor.
      The Program was seen as beneficial because it provided a structured, constructive
      means for prospective doctors to appreciate the assets rather than the deficits
      of remote area living. Another positive implication was that the Program equipped
      future doctors (regardless of their eventual work location) to treat a person
      from the 'bush'. It also encouraged students to think and act cross-culturally.
      An important immediate benefit was that the Program offered human resource
      support to the host organization at a busy time of the year. In only three of the
      33 formal interviews was a negative or ambivalent attitude toward the Program
      expressed. However, a common concern was the brevity of time students served with
      their host organization. CONCLUSIONS: The data collected revealed that Kimberley 
      people believed that the Program held strong potential for the successful
      recruitment of doctors prepared to make a long-term commitment to the region.
      Never far from their minds, conversations and activities was the idea that the
      effort they put into accommodating, supporting and guiding the students was worth
      it because 'If only one good doctor comes from the Program, then that's a good
      thing. A good doctor would have a great impact - the implications are
      immeasurable...'.
FAU - Toussaint, Sandy
AU  - Toussaint S
AD  - School of Social and Cultural Studies and School of Philosophy, Anthropology and 
      Social Inquiry, The University of Western Australia and Melbourne University,
      Perth, Western Australia, Australia. toussain@cyllene.uwa.edu.au
FAU - Mak, Donna B
AU  - Mak DB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100905
PL  - Australia
TA  - Rural Remote Health
JT  - Rural and remote health
JID - 101174860
SB  - IM
MH  - Australia
MH  - *Choice Behavior
MH  - Female
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - *Medically Underserved Area
MH  - *Professional Practice Location
MH  - *Program Evaluation
MH  - Rural Health Services
MH  - *Rural Population
MH  - Students, Medical/psychology
EDAT- 2010/09/08 06:00
MHDA- 2011/01/19 06:00
CRDT- 2010/09/08 06:00
PHST- 2010/09/08 06:00 [entrez]
PHST- 2010/09/08 06:00 [pubmed]
PHST- 2011/01/19 06:00 [medline]
AID - 1546 [pii]
PST - ppublish
SO  - Rural Remote Health. 2010 Jul-Sep;10(3):1546. Epub 2010 Sep 5.


PMID- 20818805
OWN - NLM
STAT- MEDLINE
DCOM- 20110127
LR  - 20121115
IS  - 1520-7560 (Electronic)
IS  - 1520-7552 (Linking)
VI  - 26
IP  - 7
DP  - 2010 Oct
TI  - Gene therapy and enhancement for diabetes (and other diseases): the multiplicity 
      of considerations.
PG  - 520-4
LID - 10.1002/dmrr.1116 [doi]
AB  - Gene therapy has reached the forefront of studies and research over the last 30
      years because of its potential for curing, treating, and preventing diseases
      associated with DNA mutations. Type 1 and type 2 diabetes are two examples of
      very common polygenic and multifactorial diseases. The huge amount of scientific 
      literature on this topic reflects a growing general interest in the possibilities
      of altering our genetic heritage and thus controlling the onset of diseases
      associated with mutations and relative risk factors. We have focussed on the new 
      treatment opportunities and possibility of enhancing an individual's health,
      physical well-being, and even an individual's behaviour through technologies
      specially designed for therapeutic purposes, which have been presented in
      literature. This historical perspective shows how this type of research, however,
      was immediately subjected to an ethical evaluation, especially regarding the
      decoding of the human genome and the questions raised by the alteration of our
      genetic heritage through new biotechnologies. Moreover, understanding the
      limitations of gene therapy protocol experiments and the multifactorial nature of
      many diseases, which have a genetic base, also contributes to these
      considerations.
FAU - Bertolaso, Marta
AU  - Bertolaso M
AD  - University Campus Bio-Medico of Rome, Institute of Philosophy of Scientific and
      Technological Activity, Rome, Italy. m.bertolaso@unicampus.it
FAU - Olsson, Jenny
AU  - Olsson J
FAU - Picardi, Antonio
AU  - Picardi A
FAU - Rakela, Jorge
AU  - Rakela J
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Diabetes Metab Res Rev
JT  - Diabetes/metabolism research and reviews
JID - 100883450
SB  - IM
MH  - Diabetes Mellitus, Type 1/*therapy
MH  - Diabetes Mellitus, Type 2/*therapy
MH  - Genetic Enhancement/*ethics
MH  - *Genetic Therapy
MH  - Genome, Human
MH  - Humans
MH  - Multifactorial Inheritance
EDAT- 2010/09/08 06:00
MHDA- 2011/01/29 06:00
CRDT- 2010/09/07 06:00
PHST- 2010/09/07 06:00 [entrez]
PHST- 2010/09/08 06:00 [pubmed]
PHST- 2011/01/29 06:00 [medline]
AID - 10.1002/dmrr.1116 [doi]
PST - ppublish
SO  - Diabetes Metab Res Rev. 2010 Oct;26(7):520-4. doi: 10.1002/dmrr.1116.


PMID- 20818583
OWN - NLM
STAT- MEDLINE
DCOM- 20101214
LR  - 20100906
IS  - 1029-046X (Electronic)
IS  - 1026-776X (Linking)
VI  - 21
IP  - 5-6
DP  - 2010 Jul
TI  - Role of physicochemical properties in the estimation of skin permeability: in
      vitro data assessment by Partial Least-Squares Regression.
PG  - 481-94
LID - 10.1080/1062936X.2010.501819 [doi]
AB  - Skin provides passage for the delivery of drugs. The in vitro and in vivo testing
      of chemicals for estimation of dermal absorption is very time consuming, costly
      and has many ethical difficulties related to human and animal testing. The
      solution to the problem is Quantitative structure-permeability relationships.
      This method relates dermal penetration properties of a range of chemical
      compounds to their physicochemical parameters. In the present study, an effort
      has been made to develop models for the accurate prediction of skin permeability 
      using a large, diverse dataset through the combination of various regression
      methods coupled with the Genetic Algorithm (GA)/Interval Partial Least-Squares
      Algorithm (iPLS). The descriptors were calculated using e-DRAGON and ADME Pharma 
      Algorithms-Abrahams descriptors. The original dataset was divided into a training
      set and a testing set using the Kennard-Stone Algorithm. The selection of
      descriptors was made by the GA and iPLS. The model applicability domain was
      determined. The results showed that a three-parameter model built through Partial
      Least-squares Regression was most accurate with r(2) of 0.936.
FAU - Chauhan, P
AU  - Chauhan P
AD  - Department of Bioinformatics, Maulana Azad National Institute of Technology,
      Bhopal, (M.P.), India. pallavi.chauhan2006@gmail.com
FAU - Shakya, M
AU  - Shakya M
LA  - eng
PT  - Journal Article
PL  - England
TA  - SAR QSAR Environ Res
JT  - SAR and QSAR in environmental research
JID - 9440156
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Models, Statistical
MH  - Permeability
MH  - Pharmaceutical Preparations/*chemistry/*metabolism
MH  - *Pharmacokinetics
MH  - *Quantitative Structure-Activity Relationship
MH  - Skin/*metabolism
EDAT- 2010/09/08 06:00
MHDA- 2010/12/16 06:00
CRDT- 2010/09/07 06:00
PHST- 2010/09/07 06:00 [entrez]
PHST- 2010/09/08 06:00 [pubmed]
PHST- 2010/12/16 06:00 [medline]
AID - 926603126 [pii]
AID - 10.1080/1062936X.2010.501819 [doi]
PST - ppublish
SO  - SAR QSAR Environ Res. 2010 Jul;21(5-6):481-94. doi: 10.1080/1062936X.2010.501819.


PMID- 20818559
OWN - NLM
STAT- MEDLINE
DCOM- 20101101
LR  - 20161125
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 9
DP  - 2010 Sep
TI  - A case study in unethical transgressive bioethics: "Letter of concern from
      bioethicists" about the prenatal administration of dexamethasone.
PG  - 35-45
LID - 10.1080/15265161.2010.499745 [doi]
AB  - On February 3, 2010, a "Letter of Concern from Bioethicists," organized by
      fetaldex.org, was sent to report suspected violations of the ethics of human
      subjects research in the off-label use of dexamethasone during pregnancy by Dr.
      Maria New. Copies of this letter were submitted to the FDA Office of Pediatric
      Therapeutics, the Department of Health and Human Services (DHHS) Office for Human
      Research Protections, and three universities where Dr. New has held or holds
      appointments. We provide a critical appraisal of the Letter of Concern and show
      that it makes false claims, misrepresents scientific publications and websites,
      fails to meet standards of evidence-based reasoning, makes undocumented claims,
      treats as settled matters what are, instead, ongoing controversies, offers "mere 
      opinion" as a substitute for argument, and makes contradictory claims. The Letter
      of Concern is a case study in unethical transgressive bioethics. We call on
      fetaldex.org to withdraw the letter and for co-signatories to withdraw their
      approval of it.
FAU - McCullough, Laurence B
AU  - McCullough LB
AD  - Center for Medical Ethics and Health Policy, Baylor College of Medicine, One
      Baylor Plaza, Houston, TX 77030-3411, USA. mccullou@bcm.edu
FAU - Chervenak, Frank A
AU  - Chervenak FA
FAU - Brent, Robert L
AU  - Brent RL
FAU - Hippen, Benjamin
AU  - Hippen B
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
RN  - 0 (Glucocorticoids)
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - EC 1.14.14.16 (Steroid 21-Hydroxylase)
SB  - IM
CIN - Am J Bioeth. 2010 Sep;10(9):W3-5. PMID: 20818546
CIN - Am J Bioeth. 2010 Sep;10(9):46-8. PMID: 20818560
CIN - Am J Bioeth. 2010 Sep;10(9):48-51. PMID: 20818561
CIN - Am J Bioeth. 2010 Sep;10(9):52. PMID: 20818562
CIN - Am J Bioeth. 2010 Sep;10(9):53-5. PMID: 20818563
CIN - Am J Bioeth. 2010 Sep;10(9):55-7. PMID: 20818564
CIN - Am J Bioeth. 2010 Sep;10(9):58-9. PMID: 20818565
CIN - Am J Bioeth. 2010 Sep;10(9):60-1. PMID: 20818566
CIN - Am J Bioeth. 2010 Sep;10(9):62-3. PMID: 20818567
CIN - Am J Bioeth. 2010 Sep;10(9):64-6. PMID: 20818568
CIN - Am J Bioeth. 2010 Sep;10(9):66-7. PMID: 20818569
CIN - Am J Bioeth. 2010 Sep;10(9):68-9. PMID: 20818570
CIN - Am J Bioeth. 2011 Aug;11(8):62-3. PMID: 21806448
MH  - Adrenal Hyperplasia, Congenital/complications/*diagnosis/*drug therapy/enzymology
MH  - Clinical Trials as Topic
MH  - *Correspondence as Topic
MH  - Dexamethasone/*administration & dosage
MH  - Disorders of Sex Development/etiology/*prevention & control
MH  - Drug Administration Schedule
MH  - Ethicists/*standards
MH  - Ethics Committees, Research
MH  - Female
MH  - Fetal Diseases/diagnosis/*drug therapy/enzymology
MH  - Genitalia, Female/*abnormalities/surgery
MH  - Glucocorticoids/administration & dosage
MH  - Humans
MH  - Informed Consent/ethics
MH  - Male
MH  - *Off-Label Use/ethics
MH  - Pregnancy
MH  - *Prenatal Diagnosis
MH  - Reconstructive Surgical Procedures
MH  - Referral and Consultation
MH  - Steroid 21-Hydroxylase/metabolism
MH  - Therapeutic Human Experimentation/*ethics
MH  - United States
MH  - United States Food and Drug Administration
MH  - Virilism/prevention & control
EDAT- 2010/09/08 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/09/07 06:00
PHST- 2010/09/07 06:00 [entrez]
PHST- 2010/09/08 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - 926544997 [pii]
AID - 10.1080/15265161.2010.499745 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Sep;10(9):35-45. doi: 10.1080/15265161.2010.499745.


PMID- 20818511
OWN - NLM
STAT- MEDLINE
DCOM- 20101130
LR  - 20191210
IS  - 1300-2163 (Print)
IS  - 1300-2163 (Linking)
VI  - 21
IP  - 3
DP  - 2010 Fall
TI  - [Professional containment methods used in psychiatry wards: justifications for
      their utilization, types, international practices, and perceptions].
PG  - 235-42
AB  - OBJECTIVE: The aim of this review is to examine the literature on professional
      containment methods, to draw attention to this important topic concerning which
      relevant research remains limited in our country and to offer professionals the
      opportunity to make evaluations utilizing holistic perspectives. METHOD:
      Relevant, obtainable studies published within the last 15 years, but primarily
      after the year 2000, were included in this retrospective literature review. For
      this purpose a literature search was conducted via-internet based search engines,
      including Pubmed, Science Direct, Medline, Psychinfo, the ULAKBIM Turkish
      Medicine Index and the Turkish Psychiatry Index, using the keywords containment
      methods, psychiatry, aggression, conflict, restraint, seclusion and mental health
      hospitals, in different combinations. RESULTS: According to the literature,
      professional containment methods are defined as methods used to prevent harm to
      patients or others as a result of the patient's conflict-provoking behaviour
      (aggression, absconding, rule breaking, refusing medication etc.) in psychiatric 
      wards. These methods include the use of mechanical/physical restraint, seclusion,
      compulsory intramuscular sedation, observation, and pro re nata (prn) medication.
      The type and frequency of use, views or attitudes to methods varies between
      different countries. CONCLUSION: Although professional containment methods are an
      effective management strategy, they may cause physical and psychological damage
      to both patient and staff. So the use of these methods in psychiatric care
      settings remains controversial and an ongoing source of legal and ethical
      dilemmas. Despite discussions, the containment methods used in the past remain
      present as a part of psychiatric treatment and care. There is a need for standard
      practice guidelines to ensure the security of patients and staff and to use those
      methods effectively and correctly. In conclusion, it is necessary that health
      care professionals be informed about preparing the new guidelines and using
      professional containment methods effectively.
FAU - Tekkas, Kader
AU  - Tekkas K
AD  - Okutman. Koc University Hemsirelik Yuksekokulu, Istanbul. ktekkas@ku.edu.tr
FAU - Bilgin, Hulya
AU  - Bilgin H
LA  - tur
PT  - Journal Article
PT  - Review
TT  - Psikiyatri Servislerinde Kullanilan Profesyonel Kontrol Yontemleri: Kullanim
      Nedenleri, Turleri, Uluslararasi Uygulamalar ve Algilamalar.
PL  - Turkey
TA  - Turk Psikiyatri Derg
JT  - Turk psikiyatri dergisi = Turkish journal of psychiatry
JID - 9425936
RN  - 0 (Hypnotics and Sedatives)
SB  - IM
MH  - Conflict, Psychological
MH  - Cost Control
MH  - Ethics, Medical
MH  - Humans
MH  - Hypnotics and Sedatives/therapeutic use
MH  - Legislation, Medical
MH  - Practice Guidelines as Topic
MH  - Psychiatry
MH  - Psychotic Disorders/drug therapy/economics/*therapy
MH  - Restraint, Physical
MH  - Turkey
MH  - United States
EDAT- 2010/09/08 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/09/07 06:00
PHST- 2010/09/07 06:00 [entrez]
PHST- 2010/09/08 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 768 [pii]
PST - ppublish
SO  - Turk Psikiyatri Derg. 2010 Fall;21(3):235-42.


PMID- 20817821
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20100906
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 9
DP  - 2010 Sep
TI  - Teaching practical wisdom in medicine through clinical judgement, goals of care, 
      and ethical reasoning.
PG  - 558-62
LID - 10.1136/jme.2009.035295 [doi]
AB  - Clinical decision making is a challenging task that requires practical wisdom-the
      practised ability to help patients choose wisely among available diagnostic and
      treatment options. But practical wisdom is not a concept one typically hears
      mentioned in medical training and practice. Instead, emphasis is placed on
      clinical judgement. The author draws from Aristotle and Aquinas to describe the
      virtue of practical wisdom and compare it with clinical judgement. From this
      comparison, the author suggests that a more complete understanding of clinical
      judgement requires its explicit integration with goals of care and ethical
      values. Although clinicians may be justified in assuming that goals of care and
      ethical values are implicit in routine decision making, it remains important for 
      training purposes to encourage habits of clinical judgement that are consciously 
      goal-directed and ethically informed. By connecting clinical judgement to
      patients' goals and values, clinical decisions are more likely to stay focused on
      the particular interests of individual patients. To cultivate wise clinical
      judgement among trainees, educational efforts should aim at the integration of
      clinical judgement, communication with patients about goals of care, and ethical 
      reasoning. But ultimately, training in wise clinical judgement will take years of
      practice in the company of experienced clinicians who are able to demonstrate
      practical wisdom by example. By helping trainees develop clinical judgement that 
      incorporates patients' goals of care and ethical reasoning, we may help lessen
      the risk that 'clinical judgement' will merely express 'the clinician's
      judgement.'
FAU - Kaldjian, Lauris Christopher
AU  - Kaldjian LC
AD  - Department of Internal Medicine, 1-106 MEB, University of Iowa Carver College of 
      Medicine, 500 Newton Road, Iowa City, IA 52242, USA. lauris-kaldjian@uiowa.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Clinical Medicine
MH  - Decision Making/*ethics
MH  - Education, Medical, Continuing/*methods
MH  - *Evidence-Based Medicine
MH  - Humans
MH  - Judgment/*ethics
MH  - Models, Psychological
MH  - Physicians/psychology
MH  - *Problem-Based Learning
EDAT- 2010/09/08 06:00
MHDA- 2011/11/16 06:00
CRDT- 2010/09/07 06:00
PHST- 2010/09/07 06:00 [entrez]
PHST- 2010/09/08 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - 36/9/558 [pii]
AID - 10.1136/jme.2009.035295 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Sep;36(9):558-62. doi: 10.1136/jme.2009.035295.


PMID- 20817819
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20100906
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 9
DP  - 2010 Sep
TI  - The problem of 'thick in status, thin in content' in Beauchamp and Childress'
      principlism.
PG  - 525-8
LID - 10.1136/jme.2009.031054 [doi]
AB  - For many, Thomas Beauchamp and James Childress have elaborated moral reasoning by
      using the four principles whereby all substantive problems of medical ethics (and
      of ethics more generally) can be properly analysed and cogent philosophical
      solutions for the problems can be found. It seems that their 'principlism' gets
      updated, with better features being added during the course of the six editions
      of Principles of Biomedical Ethics. Nonetheless, Beauchamp and Childress seem to 
      have been losing their way when it comes to the common-morality justification,
      which is the epistemological (and perhaps metaphysical) backbone of their method,
      and this is shown more vividly in their most recent (2009) edition of Principles 
      of Biomedical Ethics. The author points out what he calls the problem of 'thick
      in status, thin in content' in principlism. The problem exists because
      principlism cannot adequately explain how the prescriptive sense of common
      morality it supports is consistent with the existence of what Beauchamp and
      Childress call the 'legitimate moral diversity in the world'. Because of this
      problem, first, the practical end that principlism allegedly accomplishes (ie,
      providing practical moral guidelines in a relatively 'thick' content, based on
      common morality) is frustrated, and, second, principlism makes itself the method 
      of common morality de jure and of moral pluralism de facto.
FAU - Lee, Marvin J H
AU  - Lee MJ
AD  - New Being Press, 2449 Golf Road, Suite 3, Philadelphia, PA 19131. USA.
      mjhlee@newbeingpress.com
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Bioethics
MH  - *Ethical Relativism
MH  - *Ethical Theory
MH  - *Ethics, Medical
MH  - Humans
MH  - Personal Autonomy
MH  - *Principle-Based Ethics
MH  - Religion and Medicine
EDAT- 2010/09/08 06:00
MHDA- 2011/11/16 06:00
CRDT- 2010/09/07 06:00
PHST- 2010/09/07 06:00 [entrez]
PHST- 2010/09/08 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - 36/9/525 [pii]
AID - 10.1136/jme.2009.031054 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Sep;36(9):525-8. doi: 10.1136/jme.2009.031054.


PMID- 20817815
OWN - NLM
STAT- MEDLINE
DCOM- 20110315
LR  - 20191210
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 12
DP  - 2010 Dec
TI  - Pulling the heartstrings, arguing the case: a narrative response to the issue of 
      moral agency in moral distress.
PG  - 746-9
LID - 10.1136/jme.2010.036079 [doi]
AB  - In this paper it is argued that moral distress is an emotional response to an
      ethical dilemma, and that to date, the literature has largely failed to address
      the fundamental questions that need to be answered in response to this emotional 
      response. Firstly, does moral distress accurately identify a wrong being done to 
      patients? Secondly, if it does, can nurses carry out this 'wrong doing', but not 
      be responsible for the consequences of their actions? A narrative that reflects
      the emotional nature of moral distress is presented, with the aim of providing
      some answers to these questions.
FAU - Walsh, Aileen
AU  - Walsh A
AD  - Faculty of Health and Social Care, Anglia Ruskin University, Capital Park,
      Fulbourn, Cambridge CB21 5XA, UK. aileen.walsh@anglia.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20100903
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Conflict, Psychological
MH  - Emotions
MH  - *Ethics, Nursing
MH  - Humans
MH  - *Morals
MH  - Nurse-Patient Relations
MH  - Nurses/*psychology
MH  - Personal Autonomy
MH  - Stress, Psychological/*etiology
EDAT- 2010/09/08 06:00
MHDA- 2011/03/16 06:00
CRDT- 2010/09/07 06:00
PHST- 2010/09/07 06:00 [entrez]
PHST- 2010/09/08 06:00 [pubmed]
PHST- 2011/03/16 06:00 [medline]
AID - jme.2010.036079 [pii]
AID - 10.1136/jme.2010.036079 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Dec;36(12):746-9. doi: 10.1136/jme.2010.036079. Epub 2010 Sep 
      3.


PMID- 20817740
OWN - NLM
STAT- MEDLINE
DCOM- 20110203
LR  - 20101018
IS  - 1460-2350 (Electronic)
IS  - 0268-1161 (Linking)
VI  - 25
IP  - 11
DP  - 2010 Nov
TI  - A qualitative study of New Zealand fertility counsellors' roles and practices
      regarding embryo donation.
PG  - 2821-8
LID - 10.1093/humrep/deq233 [doi]
AB  - BACKGROUND: Embryo donation is a recently approved practice in New Zealand.
      Guidelines require disclosure of donor identity, openness, joint donor and
      recipient counselling and ethics approval on a case-by-case basis. This study
      explores the roles and practices of fertility counsellors in the context of New
      Zealand's policies. METHODS: Nine fertility counsellors were interviewed
      regarding their roles in the practice of embryo donation. Data were thematically 
      analysed to identify counsellors' key roles and concerns. RESULTS: Counsellors
      supported the principles underlying the policy in New Zealand. They saw their
      role as, firstly, helping patients shift from a focus on their current situations
      to considering the longer term psychosocial implications of embryo donation.
      Secondly, counsellors facilitated donors' and recipients' exploration of the
      implications not only for themselves but also for existing and potential children
      resulting from the donation and the effects on the wider family network.
      CONCLUSIONS: As determined by policy, counsellors play an integral role in
      facilitating embryo donation and regard their role as contributing to the
      long-term wellbeing of families created through and affected by embryo donation.
FAU - Goedeke, Sonja
AU  - Goedeke S
AD  - Department of Psychology, Division of Public Health and Psychosocial Studies,
      Faculty of Health and Environmental Sciences, AUT University, Auckland, New
      Zealand. sonja.goedeke@aut.ac.nz
FAU - Payne, Deborah
AU  - Payne D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100903
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
SB  - IM
MH  - *Counseling/legislation & jurisprudence
MH  - *Embryo Disposition/legislation & jurisprudence
MH  - Humans
MH  - Infertility
MH  - Living Donors/*psychology
MH  - New Zealand
MH  - *Professional Role
MH  - Qualitative Research
EDAT- 2010/09/08 06:00
MHDA- 2011/02/04 06:00
CRDT- 2010/09/07 06:00
PHST- 2010/09/07 06:00 [entrez]
PHST- 2010/09/08 06:00 [pubmed]
PHST- 2011/02/04 06:00 [medline]
AID - deq233 [pii]
AID - 10.1093/humrep/deq233 [doi]
PST - ppublish
SO  - Hum Reprod. 2010 Nov;25(11):2821-8. doi: 10.1093/humrep/deq233. Epub 2010 Sep 3.


PMID- 20817641
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20101229
IS  - 1553-3514 (Electronic)
IS  - 1553-3506 (Linking)
VI  - 17
IP  - 4
DP  - 2010 Dec
TI  - Evaluation of acute fixation strength for mechanical tacking devices and fibrin
      sealant versus polypropylene suture for laparoscopic ventral hernia repair.
PG  - 285-90
LID - 10.1177/1553350610379427 [doi]
AB  - BACKGROUND: The purpose of this comparative study is to evaluate the acute
      fixation strength of mechanical tacking devices and fibrin sealant against
      polypropylene suture for laparoscopic ventral hernia repair. METHODS: Three
      metallic mechanical tacking devices (ProTack, Salute, EndoANCHOR), 4 absorbable
      tacking devices (AbsorbaTack, PermaSorb, I-Clip, and SorbaFix), and 2 types of
      fibrin sealant (Tisseel, Artiss) were compared with 0-polypropylene suture. Three
      constructs from each device or an amount of sealant sufficient to cover a 3 x 3
      cm(2) area were used to affix a 4 x 3 cm piece of absorbable barrier-coated mesh 
      (Proceed, Ethicon, Inc) to the peritoneal surface of porcine abdominal wall. Ten 
      samples were completed for each fixation modality. Acute fixation strength was
      measured via a lap shear test on an Instron tensiometer. RESULTS: Acute fixation 
      strength was significantly greater for suture (59.7 7.2 N) compared with all
      laparoscopic tacking devices and to fibrin sealant (P < .001 for all
      comparisons). Protack (29.5 +/- 2.8 N) was stronger than Absorbatack (13.2 +/-
      3.7 N; P = .029). Protack, Permasorb, SorbaFix, and I-clip were stronger than
      fibrin sealant (P < .05 for all comparisons). CONCLUSIONS: The acute fixation
      strengths of metallic or absorbable tacks as well as fibrin sealant are all
      significantly less than that achieved with polypropylene suture. These factors
      should be considered in selecting the type of mechanical fixation for patients
      undergoing laparoscopic ventral hernia repair.
FAU - Melman, Lora
AU  - Melman L
AD  - Washington University School of Medicine, St Louis, MO 63110, USA.
FAU - Jenkins, Eric D
AU  - Jenkins ED
FAU - Deeken, Corey R
AU  - Deeken CR
FAU - Brodt, Michael D
AU  - Brodt MD
FAU - Brown, Shaun R
AU  - Brown SR
FAU - Brunt, L Michael
AU  - Brunt LM
FAU - Eagon, J Christopher
AU  - Eagon JC
FAU - Frisella, Margaret
AU  - Frisella M
FAU - Matthews, Brent D
AU  - Matthews BD
LA  - eng
PT  - Journal Article
DEP - 20100903
PL  - United States
TA  - Surg Innov
JT  - Surgical innovation
JID - 101233809
RN  - 0 (Fibrin Tissue Adhesive)
RN  - 0 (Polypropylenes)
RN  - 0 (Tissue Adhesives)
SB  - IM
MH  - Animals
MH  - Female
MH  - Fibrin Tissue Adhesive/*therapeutic use
MH  - Hernia, Ventral/*surgery
MH  - *Laparoscopy
MH  - Polypropylenes/*therapeutic use
MH  - Surgical Mesh
MH  - *Sutures
MH  - Swine
MH  - Tensile Strength
MH  - Tissue Adhesives/*therapeutic use
EDAT- 2010/09/08 06:00
MHDA- 2011/06/29 06:00
CRDT- 2010/09/07 06:00
PHST- 2010/09/07 06:00 [entrez]
PHST- 2010/09/08 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
AID - 1553350610379427 [pii]
AID - 10.1177/1553350610379427 [doi]
PST - ppublish
SO  - Surg Innov. 2010 Dec;17(4):285-90. doi: 10.1177/1553350610379427. Epub 2010 Sep
      3.


PMID- 20817572
OWN - NLM
STAT- MEDLINE
DCOM- 20110222
LR  - 20101011
IS  - 1878-4046 (Electronic)
IS  - 1076-6332 (Linking)
VI  - 17
IP  - 11
DP  - 2010 Nov
TI  - Response assessment in patients with multiple myeloma during antiangiogenic
      therapy using arterial spin labeling and diffusion-weighted imaging: a
      feasibility study.
PG  - 1326-33
LID - 10.1016/j.acra.2010.08.002 [doi]
AB  - RATIONALE AND OBJECTIVES: To determine whether response to anti-angiogenic
      therapy in patients with multiple myeloma can be assessed by noncontrast
      perfusion magnetic resonance imaging (MRI) (ie, arterial-spin-labeling [ASL]),
      and diffusion-weighted [DWI] MRI. MATERIALS AND METHODS: The study protocol was
      approved by the local institutional ethic board. Ten consecutive patients (eight 
      men, two women; mean age 60.5 +/- 8.5 years) with Stage III multiple myeloma were
      prospectively included. MRI was performed at baseline, as well as 3 and 8 weeks
      after onset of antiangiogenic therapy. Functional MRI data were compared with
      clinical outcome and conventional lesion size and signal-intensity measurements. 
      Differences between baseline and follow-up values for ASL-MRI and DWI-MRI were
      assessed using a paired Student t-test. RESULTS: Nine patients responded well to 
      therapy, whereas one patient was classified a nonresponder. Temporary changes in 
      signal intensity between baseline and follow-up examinations were inconsistent on
      T1-weighted (w) and T2w images. Likewise, determination of lesion size at
      follow-up proved unreliable. ASL showed a marked decrease in perfusion from
      baseline (251 +/- 159 mL/(min*100g)) to follow-up at 3 weeks (115 +/- 85
      mL/(min*100g), P = .01) and 8 weeks (101 +/- 90 mL/(min*100g, P = .01),
      respectively. Relative to the baseline examination, mean diffusion increased from
      0.68 +/- 0.19 x 10(-3) s/mm(2) at baseline to 0.94 +/- 0.24 x 10(-3) s/mm(2)
      after 3 weeks (P = .04), and 0.96 +/- 0.40 x 10(-3) s/mm(2) after 8 weeks (P =
      .049). Both methods were able to correctly classify 9/10 patients as responder or
      nonresponder. CONCLUSION: ASL perfusion as well as DWI-MRI provide accurate,
      clinically relevant information regarding tumor viability and can predict
      response already early after therapy onset, as opposed to classical lesion size
      and MRI signal-intensity measurements.
CI  - Copyright (c) 2010 AUR. Published by Elsevier Inc. All rights reserved.
FAU - Fenchel, Michael
AU  - Fenchel M
AD  - Department of Diagnostic and Interventional Radiology, Eberhard-Karls-University,
      Hoppe-Seyler-Str.3, 72076 Tuebingen, Germany.
      michael.fenchel@med.uni-tuebingen.de
FAU - Konaktchieva, Marina
AU  - Konaktchieva M
FAU - Weisel, Katja
AU  - Weisel K
FAU - Kraus, Sabina
AU  - Kraus S
FAU - Claussen, Claus D
AU  - Claussen CD
FAU - Horger, Marius
AU  - Horger M
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Acad Radiol
JT  - Academic radiology
JID - 9440159
RN  - 0 (Angiogenesis Inhibitors)
RN  - 0 (Spin Labels)
SB  - IM
MH  - Angiogenesis Inhibitors/*administration & dosage
MH  - Diffusion Magnetic Resonance Imaging/*methods
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Image Enhancement/methods
MH  - Magnetic Resonance Angiography/*methods
MH  - Male
MH  - Middle Aged
MH  - Multiple Myeloma/complications/*drug therapy/*pathology
MH  - Neovascularization, Pathologic/*drug therapy/etiology/*pathology
MH  - Prognosis
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Spin Labels
MH  - Treatment Outcome
EDAT- 2010/09/08 06:00
MHDA- 2011/02/23 06:00
CRDT- 2010/09/07 06:00
PHST- 2010/05/29 00:00 [received]
PHST- 2010/07/23 00:00 [revised]
PHST- 2010/08/03 00:00 [accepted]
PHST- 2010/09/07 06:00 [entrez]
PHST- 2010/09/08 06:00 [pubmed]
PHST- 2011/02/23 06:00 [medline]
AID - S1076-6332(10)00416-2 [pii]
AID - 10.1016/j.acra.2010.08.002 [doi]
PST - ppublish
SO  - Acad Radiol. 2010 Nov;17(11):1326-33. doi: 10.1016/j.acra.2010.08.002.


PMID- 20816732
OWN - NLM
STAT- MEDLINE
DCOM- 20110131
LR  - 20131121
IS  - 1873-3476 (Electronic)
IS  - 0378-5173 (Linking)
VI  - 400
IP  - 1-2
DP  - 2010 Nov 15
TI  - Rational development of taste masked oral liquids guided by an electronic tongue.
PG  - 114-23
LID - 10.1016/j.ijpharm.2010.08.042 [doi]
AB  - Human taste testing is often associated with ethical concerns, organizational and
      validation issues. Electrochemical sensor array systems, so called electronic
      tongues, offer an alternative to assess the taste of multi-component liquid
      formulations. Therefore, it should be investigated how an electronic tongue can
      be implemented in the rational development of taste masked formulations. Taste
      masking of bitter tasting quinine hydrochloride (QH) in a liquid formulation was 
      carried out by screening sweetening agents (sucrose, glucose, fructose, mannitol,
      sucralose, sodium saccharin, acesulfame potassium, and monoammonium
      glycyrrhizinate), strong and weak cation ion exchange (IE) resins (Amberlite
      IRP69, Amberlite IRP88, and Indion 234), and soluble complexing agents (alpha-,
      beta-, hydroxypropyl-beta-, sulfobutyl ether-beta- and gamma-cyclodextrin and
      maltodextrin). Amberlite IRP88 showed the best binding capacity for quinine (1.9 
      g quinine/1 g IE). The addition of sulfobutyl ether-beta-cyclodextrin
      (SBE-beta-CD) could significantly reduce the bitter taste of QH (79% reduction of
      free QH). The SBE-beta-CD formulation was further improved by adding sodium
      saccharin as secondary taste masking agent. It could also be shown that presence 
      of strawberry flavor and the preservative domiphen bromide does not affect
      evaluation of taste masking efficiency. The introduced stepwise approach was
      shown to be applicable to rationally develop novel taste masked formulations.
CI  - Copyright (c) 2010 Elsevier B.V. All rights reserved.
FAU - Woertz, Katharina
AU  - Woertz K
AD  - Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University
      Duesseldorf, Universitaetsstr. 1, 40225 Duesseldorf, Germany.
      Katharina.Woertz@uni-duesseldorf.de
FAU - Tissen, Corinna
AU  - Tissen C
FAU - Kleinebudde, Peter
AU  - Kleinebudde P
FAU - Breitkreutz, Jorg
AU  - Breitkreutz J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100909
PL  - Netherlands
TA  - Int J Pharm
JT  - International journal of pharmaceutics
JID - 7804127
RN  - 0 (Cation Exchange Resins)
RN  - 0 (Cyclodextrins)
RN  - 0 (Sweetening Agents)
RN  - A7V27PHC7A (Quinine)
SB  - IM
MH  - *Biosensing Techniques/instrumentation
MH  - Cation Exchange Resins/chemistry
MH  - Chemistry, Pharmaceutical
MH  - Cyclodextrins/chemistry
MH  - Electrical Equipment and Supplies
MH  - Humans
MH  - Principal Component Analysis
MH  - Quinine/chemistry
MH  - Sweetening Agents/chemistry
MH  - *Taste
MH  - Technology, Pharmaceutical
MH  - *Tongue
EDAT- 2010/09/08 06:00
MHDA- 2011/02/01 06:00
CRDT- 2010/09/07 06:00
PHST- 2010/07/14 00:00 [received]
PHST- 2010/08/19 00:00 [revised]
PHST- 2010/08/25 00:00 [accepted]
PHST- 2010/09/07 06:00 [entrez]
PHST- 2010/09/08 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
AID - S0378-5173(10)00672-1 [pii]
AID - 10.1016/j.ijpharm.2010.08.042 [doi]
PST - ppublish
SO  - Int J Pharm. 2010 Nov 15;400(1-2):114-23. doi: 10.1016/j.ijpharm.2010.08.042.
      Epub 2010 Sep 9.


PMID- 20816574
OWN - NLM
STAT- MEDLINE
DCOM- 20110121
LR  - 20151119
IS  - 1558-1977 (Electronic)
IS  - 0889-8588 (Linking)
VI  - 24
IP  - 5
DP  - 2010 Oct
TI  - Inherited predisposition to cancer: introduction and overview.
PG  - 793-7
LID - 10.1016/j.hoc.2010.06.005 [doi]
AB  - The past three decades have witnessed an explosion in information regarding the
      genetic mutations underlying predisposition to common malignancies. Discoveries
      are now being made regarding genomic variants associated with disease risk for,
      and outcome following, treatment for cancer. Responsible translation of these
      discoveries to medical practice requires attention to principles of clinical
      utility as well as social and ethical aspects.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Robson, Mark
AU  - Robson M
AD  - Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering
      Cancer Center, New York, NY 10065, USA.
FAU - Offit, Kenneth
AU  - Offit K
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Hematol Oncol Clin North Am
JT  - Hematology/oncology clinics of North America
JID - 8709473
SB  - IM
MH  - *Genetic Predisposition to Disease
MH  - Genetic Testing
MH  - Humans
MH  - Neoplastic Syndromes, Hereditary/*genetics
MH  - Practice Guidelines as Topic
MH  - Precision Medicine
EDAT- 2010/09/08 06:00
MHDA- 2011/01/22 06:00
CRDT- 2010/09/07 06:00
PHST- 2010/09/07 06:00 [entrez]
PHST- 2010/09/08 06:00 [pubmed]
PHST- 2011/01/22 06:00 [medline]
AID - S0889-8588(10)00094-8 [pii]
AID - 10.1016/j.hoc.2010.06.005 [doi]
PST - ppublish
SO  - Hematol Oncol Clin North Am. 2010 Oct;24(5):793-7. doi:
      10.1016/j.hoc.2010.06.005.


PMID- 20816425
OWN - NLM
STAT- MEDLINE
DCOM- 20160422
LR  - 20181201
IS  - 0072-9752 (Print)
IS  - 0072-9752 (Linking)
VI  - 97
DP  - 2010
TI  - Ethical issues in headache management.
PG  - 239-44
LID - 10.1016/S0072-9752(10)97019-X [doi]
FAU - Steiner, Timothy J
AU  - Steiner TJ
AD  - Division of Neuroscience and Mental Health, Imperial College London, London, UK. 
      t.steiner@imperial.ac.uk
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Handb Clin Neurol
JT  - Handbook of clinical neurology
JID - 0166161
SB  - IM
MH  - *Disease Management
MH  - *Headache
MH  - Humans
EDAT- 2010/09/08 06:00
MHDA- 2016/04/23 06:00
CRDT- 2010/09/07 06:00
PHST- 2010/09/07 06:00 [entrez]
PHST- 2010/09/08 06:00 [pubmed]
PHST- 2016/04/23 06:00 [medline]
AID - S0072-9752(10)97019-X [pii]
AID - 10.1016/S0072-9752(10)97019-X [doi]
PST - ppublish
SO  - Handb Clin Neurol. 2010;97:239-44. doi: 10.1016/S0072-9752(10)97019-X.


PMID- 20816368
OWN - NLM
STAT- MEDLINE
DCOM- 20110104
LR  - 20100906
IS  - 1878-7452 (Electronic)
IS  - 1878-7452 (Linking)
VI  - 67
IP  - 4
DP  - 2010 Jul-Aug
TI  - Consensus statement on the adoption of the Committee on Publication Ethics (COPE)
      guidelines.
PG  - 274
LID - 10.1016/j.jsurg.2010.06.011 [doi]
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Surg Educ
JT  - Journal of surgical education
JID - 101303204
SB  - IM
MH  - Consensus
MH  - Guidelines as Topic
MH  - Publications/*ethics/standards
MH  - Publishing/*ethics/standards
MH  - *Scientific Misconduct
EDAT- 2010/09/08 06:00
MHDA- 2011/01/05 06:00
CRDT- 2010/09/07 06:00
PHST- 2010/09/07 06:00 [entrez]
PHST- 2010/09/08 06:00 [pubmed]
PHST- 2011/01/05 06:00 [medline]
AID - S1931-7204(10)00179-0 [pii]
AID - 10.1016/j.jsurg.2010.06.011 [doi]
PST - ppublish
SO  - J Surg Educ. 2010 Jul-Aug;67(4):274. doi: 10.1016/j.jsurg.2010.06.011.


PMID- 20816309
OWN - NLM
STAT- MEDLINE
DCOM- 20100928
LR  - 20151119
IS  - 1097-6752 (Electronic)
IS  - 0889-5406 (Linking)
VI  - 138
IP  - 3
DP  - 2010 Sep
TI  - Litigation, legislation, and ethics: Calling it quits.
PG  - 372-4
LID - 10.1016/j.ajodo.2010.06.011 [doi]
FAU - Jerrold, Laurance
AU  - Jerrold L
AD  - Jacksonville University, Fla., USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Orthod Dentofacial Orthop
JT  - American journal of orthodontics and dentofacial orthopedics : official
      publication of the American Association of Orthodontists, its constituent
      societies, and the American Board of Orthodontics
JID - 8610224
SB  - IM
MH  - Clinical Competence
MH  - Dental Records/legislation & jurisprudence
MH  - Dentists/ethics/legislation & jurisprudence
MH  - Follow-Up Studies
MH  - Humans
MH  - *Orthodontic Retainers
MH  - Orthodontics/ethics/*legislation & jurisprudence
MH  - Patient Care Planning
MH  - Practice Patterns, Dentists'
MH  - Treatment Outcome
EDAT- 2010/09/08 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/09/07 06:00
PHST- 2010/06/01 00:00 [received]
PHST- 2010/06/01 00:00 [revised]
PHST- 2010/06/01 00:00 [accepted]
PHST- 2010/09/07 06:00 [entrez]
PHST- 2010/09/08 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - S0889-5406(10)00583-4 [pii]
AID - 10.1016/j.ajodo.2010.06.011 [doi]
PST - ppublish
SO  - Am J Orthod Dentofacial Orthop. 2010 Sep;138(3):372-4. doi:
      10.1016/j.ajodo.2010.06.011.


PMID- 20815691
OWN - NLM
STAT- MEDLINE
DCOM- 20110623
LR  - 20110304
IS  - 1748-3115 (Electronic)
IS  - 1748-3107 (Linking)
VI  - 6
IP  - 2
DP  - 2011
TI  - Looking ahead: planning for the first human intracortical visual prosthesis by
      using pilot data from focus groups of potential users.
PG  - 139-47
LID - 10.3109/17483107.2010.514381 [doi]
AB  - In planning for our research team's first human implant of a technologically
      advanced intracortical visual prosthesis we have conducted three focus groups
      with blind persons from a pool of likely participants. Guided by the principles
      of the Independent Living movement and Participatory Action Research (PAR), we
      asked the participants to share their thoughts and concerns about the procedure. 
      The preliminary results reveal that achievement of the desired highest ethical of
      informed consent will require extensive pre-operative learning opportunities,
      such as those provided by these focus groups. Persons who are blind may be
      motivated to participate in research like this based on a need to know,
      understand, and explore ones environment, to leave a legacy, and to experience
      some restored perception.
FAU - Lane, Frank John
AU  - Lane FJ
AD  - Illinois Institute of Technology, Chicago, IL 60616, United States.
FAU - Huyck, Margaret Hellie
AU  - Huyck MH
FAU - Troyk, Philip
AU  - Troyk P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100903
PL  - England
TA  - Disabil Rehabil Assist Technol
JT  - Disability and rehabilitation. Assistive technology
JID - 101255937
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Community-Based Participatory Research/*organization & administration
MH  - Female
MH  - Focus Groups
MH  - Humans
MH  - Informed Consent
MH  - Male
MH  - Middle Aged
MH  - Research Design
MH  - Visual Cortex/*surgery
MH  - *Visual Prosthesis
MH  - Visually Impaired Persons/*rehabilitation
EDAT- 2010/09/08 06:00
MHDA- 2011/06/24 06:00
CRDT- 2010/09/07 06:00
PHST- 2010/09/07 06:00 [entrez]
PHST- 2010/09/08 06:00 [pubmed]
PHST- 2011/06/24 06:00 [medline]
AID - 10.3109/17483107.2010.514381 [doi]
PST - ppublish
SO  - Disabil Rehabil Assist Technol. 2011;6(2):139-47. doi:
      10.3109/17483107.2010.514381. Epub 2010 Sep 3.


PMID- 20815294
OWN - NLM
STAT- MEDLINE
DCOM- 20101102
LR  - 20100906
IS  - 1121-189X (Print)
IS  - 1121-189X (Linking)
VI  - 19
IP  - 2
DP  - 2010 Apr-Jun
TI  - What is a clinical trial protocol?
PG  - 116-7
AB  - Trial protocols are documents that describe the objectives, design, methodology, 
      statistical considerations and aspects related to the organization of clinical
      trials. Trial protocols provide the background and rationale for conducting a
      study, highlighting specific research questions that are addressed, and taking
      into consideration ethical issues. Trial protocols must meet a standard that
      adheres to the principles of Good Clinical Practice, and are used to obtain
      ethics approval by local Ethics Committees or Institutional Review Boards.
FAU - Cipriani, Andrea
AU  - Cipriani A
AD  - Department of Medicine and Public Health, Section of Psychiatry and Clinical
      Psychology, University of Verona, Italy. andrea.cipriani@univr.it
FAU - Barbui, Corrado
AU  - Barbui C
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Epidemiol Psichiatr Soc
JT  - Epidemiologia e psichiatria sociale
JID - 9501447
SB  - IM
MH  - *Clinical Protocols
MH  - Clinical Trials as Topic/*standards
MH  - Humans
EDAT- 2010/09/08 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/09/07 06:00
PHST- 2010/09/07 06:00 [entrez]
PHST- 2010/09/08 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
PST - ppublish
SO  - Epidemiol Psichiatr Soc. 2010 Apr-Jun;19(2):116-7.


PMID- 20815248
OWN - NLM
STAT- MEDLINE
DCOM- 20110926
LR  - 20100906
IS  - 1000-3061 (Print)
IS  - 1000-3061 (Linking)
VI  - 26
IP  - 6
DP  - 2010 Jun
TI  - [From human genome to man-made life: J. Craig Venter leads the life sciences].
PG  - 697-706
AB  - For the first time ever, the scientists of J. Craig Venter team have created
      actual self-replicating synthetic life. The research was just published in the
      Journal of Science on May 20, 2010. Although this news immediately brings the
      worry about the possible potential threat to biosecurity and biosafety as well as
      the ethical disputes, it yet indicates that mankind have made a new step forward 
      in synthetic biology. In the time of post-genome era, we believe the advancement 
      of synthetic biology that might affect or change the future life of human being
      will be widely used in energy, environment, materials, medication and many other 
      fields.
FAU - Sun, Mingwei
AU  - Sun M
AD  - CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of
      Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
FAU - Li, Yin
AU  - Li Y
FAU - Gao, George F
AU  - Gao GF
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - China
TA  - Sheng Wu Gong Cheng Xue Bao
JT  - Sheng wu gong cheng xue bao = Chinese journal of biotechnology
JID - 9426463
SB  - IM
MH  - Biological Science Disciplines/*methods
MH  - *Cloning, Organism
MH  - Genome, Human/*genetics
MH  - Human Genome Project
MH  - Humans
MH  - Synthetic Biology/*trends
EDAT- 2010/09/08 06:00
MHDA- 2011/09/29 06:00
CRDT- 2010/09/07 06:00
PHST- 2010/09/07 06:00 [entrez]
PHST- 2010/09/08 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
PST - ppublish
SO  - Sheng Wu Gong Cheng Xue Bao. 2010 Jun;26(6):697-706.


PMID- 20815169
OWN - NLM
STAT- MEDLINE
DCOM- 20101105
LR  - 20100906
IS  - 1426-9686 (Print)
IS  - 1426-9686 (Linking)
VI  - 28
IP  - 165
DP  - 2010 Mar
TI  - [How can we establish hospital ethics committees?].
PG  - 207-10
AB  - The necessity of establishing hospital ethics committees (HEC) in Poland is
      obvious. Limitations of such initiatives are related with lack of standards,
      financial support, legal provisions and well trained and educated candidates on
      members of HECs. HECs should: protect patient's rights and their beneficience,
      facilitate ethics education for doctors and other health professionals and
      provide ethics advice in individual cases. Members of HECs should present a broad
      range of disciplines and backgrounds. They should provide a comprehensive and
      reliable opinion in which all medical, legal and ethical aspects should be
      mentioned. All members should have a basic knowledge of medical ethics, related
      legal provisions and Medical Code of Ethics. Different models of ethics support
      should be provided. Ethical consultation of single specialist and committee or
      subcommittee debates are possible choices. It is necessary to prepare operating
      procedures for HECs which will provide standard and unified formalities for all
      referred cases. Hospital management who is interested in establishing HEC should 
      provide adequate financial support. Members of HECs should be encouraged to
      upgrade their skills and knowledge.
FAU - Czarkowski, Marek
AU  - Czarkowski M
AD  - Warszawski Uniwersytet Medyczny, Klinika Chorob Wewnetrznych i Endokrynologii.
      mczark@gmail.com
LA  - pol
PT  - English Abstract
PT  - Journal Article
TT  - Jak zakladac szpitalne komisje etyczne?
PL  - Poland
TA  - Pol Merkur Lekarski
JT  - Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
JID - 9705469
SB  - IM
MH  - Ethics Committees, Clinical/economics/*organization & administration
MH  - Poland
MH  - Policy Making
EDAT- 2010/09/08 06:00
MHDA- 2010/11/06 06:00
CRDT- 2010/09/07 06:00
PHST- 2010/09/07 06:00 [entrez]
PHST- 2010/09/08 06:00 [pubmed]
PHST- 2010/11/06 06:00 [medline]
PST - ppublish
SO  - Pol Merkur Lekarski. 2010 Mar;28(165):207-10.


PMID- 20815115
OWN - NLM
STAT- MEDLINE
DCOM- 20110112
LR  - 20100903
IS  - 1751-0813 (Electronic)
IS  - 0005-0423 (Linking)
VI  - 88
IP  - 9
DP  - 2010 Sep
TI  - Re: Sheba - an ethical dilemma.
PG  - N26
FAU - Pearson, Melinda
AU  - Pearson M
LA  - eng
PT  - Letter
PL  - England
TA  - Aust Vet J
JT  - Australian veterinary journal
JID - 0370616
SB  - IM
MH  - Animals
MH  - Euthanasia, Animal/*ethics
MH  - Humans
MH  - *Pets
MH  - Veterinarians/*ethics
EDAT- 2010/09/08 06:00
MHDA- 2011/01/13 06:00
CRDT- 2010/09/07 06:00
PHST- 2010/09/07 06:00 [entrez]
PHST- 2010/09/08 06:00 [pubmed]
PHST- 2011/01/13 06:00 [medline]
PST - ppublish
SO  - Aust Vet J. 2010 Sep;88(9):N26.


PMID- 20814270
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20100903
IS  - 1550-1841 (Electronic)
IS  - 0741-5206 (Linking)
VI  - 30
IP  - 3
DP  - 2010 Jul-Sep
TI  - The ethical dilemmas of aesthetic medicine: what every provider should consider.
PG  - 152-5; quiz 156
LID - 10.1097/PSN.0b013e3181ee1789 [doi]
AB  - The purpose of aesthetic medicine is embellishment and enhancement. As these
      procedures are elective in nature, media messages and misleading advertisements
      do influence those consumers seeking to improve or enhance their appearance. The 
      role of provider demands that prudent guide these treatment options and not only 
      succumb to patient demands. This article discusses the ethical principles of
      autonomy, beneficence, nonmaleficence, and justice, and presents a framework to
      guide practice to enhance resolution of ethical dilemmas confronting the provider
      of aesthetic medicine.
FAU - Spear, Marcia
AU  - Spear M
AD  - Department of Plastic Surgery, Vanderbilt University Medical Center, Nashville,
      Tennessee, USA. marcia.spear@vanderbilt.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Plast Surg Nurs
JT  - Plastic surgical nursing : official journal of the American Society of Plastic
      and Reconstructive Surgical Nurses
JID - 8403490
MH  - Esthetics
MH  - *Ethics, Nursing
MH  - Humans
MH  - *Nurse's Role
MH  - Nurse-Patient Relations/*ethics
MH  - Nursing Assessment/ethics
MH  - Patient Advocacy/*ethics
MH  - Patient Education as Topic/*ethics
MH  - Personal Autonomy
MH  - Reconstructive Surgical Procedures/*ethics
EDAT- 2010/09/04 06:00
MHDA- 2011/01/07 06:00
CRDT- 2010/09/04 06:00
PHST- 2010/09/04 06:00 [entrez]
PHST- 2010/09/04 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
AID - 10.1097/PSN.0b013e3181ee1789 [doi]
AID - 00006527-201007000-00006 [pii]
PST - ppublish
SO  - Plast Surg Nurs. 2010 Jul-Sep;30(3):152-5; quiz 156. doi:
      10.1097/PSN.0b013e3181ee1789.


PMID- 20814260
OWN - NLM
STAT- MEDLINE
DCOM- 20101229
LR  - 20100903
IS  - 1536-7312 (Electronic)
IS  - 0196-206X (Linking)
VI  - 31
IP  - 7
DP  - 2010 Sep
TI  - An overview of newborn screening.
PG  - 622-31
LID - 10.1097/DBP.0b013e3181eedf01 [doi]
AB  - This review of newborn screening examines the beginning of screening with the
      story of phenylketonuria and explores the principles of screening and the
      criteria with which disorders were added to newborn screening panels. The
      explosion of tests that are screened for followed the adoption of tandem mass
      spectrometry (MS-MS) technology. The inequity of state newborn screening panels
      was brought to the forefront with an American Academy of Pediatrics task force
      report in 2000 that called for a national panel. The American College of Medical 
      Genetics convened an expert panel to produce such a panel. In 2006, they
      published their panel of disorders, recommending a panel of 29 core disorders and
      25 additional secondary targets. Ethical arguments about newborn screening have
      resurfaced with the recent expansion of testing that include arguments about
      consent, mandatory participation, benefits to those screened, and cost-both to
      the individual and society. Finally, the future direction of screening is
      discussed. Newborn screening is undergoing rapid expansion. The addition of tests
      involves ethical, financial, and social pressures.
FAU - Levy, Paul A
AU  - Levy PA
AD  - Department of Pediatrics, Albert Einstein College of Medicine, Children's
      Hospital at Montefiore, Bronx, NY, USA. plevy@montefiore.org
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Dev Behav Pediatr
JT  - Journal of developmental and behavioral pediatrics : JDBP
JID - 8006933
SB  - IM
MH  - Expert Testimony
MH  - Genetic Diseases, Inborn/*diagnosis
MH  - Genetics, Medical
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Newborn, Diseases/*diagnosis
MH  - Neonatal Screening/economics/ethics/*methods/trends
MH  - Pediatrics
MH  - Phenylketonurias/diagnosis
MH  - Societies, Medical
MH  - *Tandem Mass Spectrometry
EDAT- 2010/09/04 06:00
MHDA- 2010/12/30 06:00
CRDT- 2010/09/04 06:00
PHST- 2010/09/04 06:00 [entrez]
PHST- 2010/09/04 06:00 [pubmed]
PHST- 2010/12/30 06:00 [medline]
AID - 10.1097/DBP.0b013e3181eedf01 [doi]
AID - 00004703-201009000-00015 [pii]
PST - ppublish
SO  - J Dev Behav Pediatr. 2010 Sep;31(7):622-31. doi: 10.1097/DBP.0b013e3181eedf01.


PMID- 20814148
OWN - NLM
STAT- MEDLINE
DCOM- 20101123
LR  - 20100903
IS  - 1319-2442 (Print)
IS  - 1319-2442 (Linking)
VI  - 21
IP  - 5
DP  - 2010 Sep
TI  - Ethical disputes in living donor kidney transplantation: what should we do to
      save lives?
PG  - 971-4
AB  - Living donor kidney transplantation has strong opposition and proponents.
      Opponents argue that this would exploit poor and female while proponents discuss 
      the high mortality rate of ESRD patients and the low risk of a living donation.
      In this debate, we reviewed disputes in ethical aspects of living donor kidney
      transplantation to reach to a good overview of the current concepts on the issue.
FAU - Khedmat, Hossein
AU  - Khedmat H
AD  - Department of Internal Medicine, Baqiyatallah Research Center for
      Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences,
      Baqiyatallah Hospital, Tehran, Iran. Khedmat.h@gmail.com
FAU - Taheri, Saeed
AU  - Taheri S
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Saudi Arabia
TA  - Saudi J Kidney Dis Transpl
JT  - Saudi journal of kidney diseases and transplantation : an official publication of
      the Saudi Center for Organ Transplantation, Saudi Arabia
JID - 9436968
SB  - IM
MH  - Altruism
MH  - Compensation and Redress/ethics
MH  - Female
MH  - Gift Giving
MH  - Humans
MH  - Informed Consent/ethics
MH  - Iran
MH  - Kidney Failure, Chronic/mortality/*surgery
MH  - Kidney Transplantation/economics/*ethics
MH  - Living Donors/*ethics
MH  - Male
MH  - Poverty
MH  - Presumed Consent/ethics
MH  - Sex Factors
EDAT- 2010/09/04 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/09/04 06:00
PHST- 2010/09/04 06:00 [entrez]
PHST- 2010/09/04 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - SaudiJKidneyDisTranspl_2010_21_5_971_68909 [pii]
PST - ppublish
SO  - Saudi J Kidney Dis Transpl. 2010 Sep;21(5):971-4.


PMID- 20813861
OWN - NLM
STAT- MEDLINE
DCOM- 20110310
LR  - 20220316
IS  - 1464-3685 (Electronic)
IS  - 0300-5771 (Linking)
VI  - 39
IP  - 5
DP  - 2010 Oct
TI  - Quality, quantity and harmony: the DataSHaPER approach to integrating data across
      bioclinical studies.
PG  - 1383-93
LID - 10.1093/ije/dyq139 [doi]
AB  - BACKGROUND: Vast sample sizes are often essential in the quest to disentangle the
      complex interplay of the genetic, lifestyle, environmental and social factors
      that determine the aetiology and progression of chronic diseases. The pooling of 
      information between studies is therefore of central importance to contemporary
      bioscience. However, there are many technical, ethico-legal and scientific
      challenges to be overcome if an effective, valid, pooled analysis is to be
      achieved. Perhaps most critically, any data that are to be analysed in this way
      must be adequately 'harmonized'. This implies that the collection and recording
      of information and data must be done in a manner that is sufficiently similar in 
      the different studies to allow valid synthesis to take place. METHODS: This
      conceptual article describes the origins, purpose and scientific foundations of
      the DataSHaPER (DataSchema and Harmonization Platform for Epidemiological
      Research; http://www.datashaper.org), which has been created by a
      multidisciplinary consortium of experts that was pulled together and coordinated 
      by three international organizations: P(3)G (Public Population Project in
      Genomics), PHOEBE (Promoting Harmonization of Epidemiological Biobanks in Europe)
      and CPT (Canadian Partnership for Tomorrow Project). RESULTS: The DataSHaPER
      provides a flexible, structured approach to the harmonization and pooling of
      information between studies. Its two primary components, the 'DataSchema' and
      'Harmonization Platforms', together support the preparation of effective
      data-collection protocols and provide a central reference to facilitate
      harmonization. The DataSHaPER supports both 'prospective' and 'retrospective'
      harmonization. CONCLUSION: It is hoped that this article will encourage readers
      to investigate the project further: the more the research groups and studies are 
      actively involved, the more effective the DataSHaPER programme will ultimately
      be.
FAU - Fortier, Isabel
AU  - Fortier I
AD  - Public Population Project in Genomics (P(3)G), Montreal, QC, Canada.
      ifortier@p3g.org
FAU - Burton, Paul R
AU  - Burton PR
FAU - Robson, Paula J
AU  - Robson PJ
FAU - Ferretti, Vincent
AU  - Ferretti V
FAU - Little, Julian
AU  - Little J
FAU - L'Heureux, Francois
AU  - L'Heureux F
FAU - Deschenes, Mylene
AU  - Deschenes M
FAU - Knoppers, Bartha M
AU  - Knoppers BM
FAU - Doiron, Dany
AU  - Doiron D
FAU - Keers, Joost C
AU  - Keers JC
FAU - Linksted, Pamela
AU  - Linksted P
FAU - Harris, Jennifer R
AU  - Harris JR
FAU - Lachance, Genevieve
AU  - Lachance G
FAU - Boileau, Catherine
AU  - Boileau C
FAU - Pedersen, Nancy L
AU  - Pedersen NL
FAU - Hamilton, Carol M
AU  - Hamilton CM
FAU - Hveem, Kristian
AU  - Hveem K
FAU - Borugian, Marilyn J
AU  - Borugian MJ
FAU - Gallagher, Richard P
AU  - Gallagher RP
FAU - McLaughlin, John
AU  - McLaughlin J
FAU - Parker, Louise
AU  - Parker L
FAU - Potter, John D
AU  - Potter JD
FAU - Gallacher, John
AU  - Gallacher J
FAU - Kaaks, Rudolf
AU  - Kaaks R
FAU - Liu, Bette
AU  - Liu B
FAU - Sprosen, Tim
AU  - Sprosen T
FAU - Vilain, Anne
AU  - Vilain A
FAU - Atkinson, Susan A
AU  - Atkinson SA
FAU - Rengifo, Andrea
AU  - Rengifo A
FAU - Morton, Robin
AU  - Morton R
FAU - Metspalu, Andres
AU  - Metspalu A
FAU - Wichmann, H Erich
AU  - Wichmann HE
FAU - Tremblay, Mark
AU  - Tremblay M
FAU - Chisholm, Rex L
AU  - Chisholm RL
FAU - Garcia-Montero, Andres
AU  - Garcia-Montero A
FAU - Hillege, Hans
AU  - Hillege H
FAU - Litton, Jan-Eric
AU  - Litton JE
FAU - Palmer, Lyle J
AU  - Palmer LJ
FAU - Perola, Markus
AU  - Perola M
FAU - Wolffenbuttel, Bruce H R
AU  - Wolffenbuttel BH
FAU - Peltonen, Leena
AU  - Peltonen L
FAU - Hudson, Thomas J
AU  - Hudson TJ
LA  - eng
GR  - CZD/16/6/2/CSO_/Chief Scientist Office/United Kingdom
GR  - G0601625/MRC_/Medical Research Council/United Kingdom
GR  - 086160/Z/08/A/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100902
PL  - England
TA  - Int J Epidemiol
JT  - International journal of epidemiology
JID - 7802871
SB  - IM
MH  - Clinical Trials as Topic/*statistics & numerical data
MH  - Data Collection/methods
MH  - *Data Interpretation, Statistical
MH  - *Epidemiologic Methods
MH  - Health Behavior
MH  - Humans
MH  - Information Storage and Retrieval/*methods
MH  - *Meta-Analysis as Topic
MH  - Residence Characteristics
MH  - Socioeconomic Factors
PMC - PMC2972444
EDAT- 2010/09/04 06:00
MHDA- 2011/03/11 06:00
CRDT- 2010/09/04 06:00
PHST- 2010/09/04 06:00 [entrez]
PHST- 2010/09/04 06:00 [pubmed]
PHST- 2011/03/11 06:00 [medline]
AID - dyq139 [pii]
AID - 10.1093/ije/dyq139 [doi]
PST - ppublish
SO  - Int J Epidemiol. 2010 Oct;39(5):1383-93. doi: 10.1093/ije/dyq139. Epub 2010 Sep
      2.


PMID- 20813718
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20100930
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 10
DP  - 2010 Oct
TI  - The 2008 Declaration of Helsinki: some reflections.
PG  - 598-603
LID - 10.1136/jme.2009.034132 [doi]
AB  - This paper reflects on some amendments to the Declaration of Helsinki in 2008. It
      focuses on former paragraphs 5 (now 6) and 19 (now 17). Paragraph 5 suggested
      that the wellbeing of research participants should take precedence over the
      interests of science and society. Paragraph 6 now proposes that it should take
      precedence over all other interests. Paragraph 19, and the new paragraph 17,
      suggest that research involving the members of a disadvantaged population is only
      justified if the clinical trial is likely to benefit them. In both cases, the
      recommendation is that the interests of the research subjects should prevail over
      the interests of third parties. This paper assesses the plausibility of these
      statements, and in order to do so, considers debates on the moral duty to
      participate in biomedical research. It is argued that, even if seen in the
      context of the Declaration as a whole, the statements contained in these
      paragraphs risk offering a misleading portrait of science and risk eroding some
      of the ethical principles that should form the basis of a satisfactory shared
      life, such as altruism and responsibility for our fellows.
FAU - Giordano, Simona
AU  - Giordano S
AD  - The University of Manchester, The School of Law, Williamson Building, Oxford
      Road, Manchester M13 9PL, USA. simona.giordano@manchester.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20100901
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Clinical Trials as Topic/*ethics/legislation & jurisprudence
MH  - Conflict of Interest
MH  - *Ethics, Medical
MH  - Ethics, Research
MH  - *Helsinki Declaration
MH  - Humans
MH  - *Research Subjects
MH  - Social Justice
EDAT- 2010/09/04 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/09/04 06:00
PHST- 2010/09/04 06:00 [entrez]
PHST- 2010/09/04 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - jme.2009.034132 [pii]
AID - 10.1136/jme.2009.034132 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Oct;36(10):598-603. doi: 10.1136/jme.2009.034132. Epub 2010
      Sep 1.


PMID- 20813517
OWN - NLM
STAT- MEDLINE
DCOM- 20110121
LR  - 20131121
IS  - 1532-3374 (Electronic)
IS  - 0959-289X (Linking)
VI  - 19
IP  - 4
DP  - 2010 Oct
TI  - Addition of low-dose morphine to intrathecal bupivacaine/sufentanil labour
      analgesia: A randomised controlled study.
PG  - 384-9
LID - 10.1016/j.ijoa.2010.04.003 [doi]
AB  - BACKGROUND: Single-shot spinal analgesia with bupivacaine and a short-acting
      opioid for labour pain is popular due to its simplicity, rapid onset, and
      profound analgesia without significant motor block. Its limitation is the short
      duration of action. Supplementation with intrathecal morphine has been shown to
      prolong analgesia. We compared the addition of placebo or morphine 50 or 100 mug 
      to intrathecal bupivacaine and sufentanil to evaluate the impact on duration of
      labour analgesia. METHOD: Following ethics committee approval and verbal and
      written patient consent, 90 healthy nulliparous women were included in the study.
      As part of a combined spinal-epidural technique, women were randomised to receive
      intrathecal bupivacaine 1.25mg and sufentanil 5 mug with morphine 50 mug, 100 mug
      or saline placebo in a double-blind fashion. Onset of analgesia was measured as
      the time from intrathecal injection to a visual analogue scale pain score < or =4
      (scale 0-10) and the duration of analgesia as the time from intrathecal injection
      to the return of pain >4. RESULTS: No significant differences between the groups 
      were seen in onset or duration of analgesia, side effects or obstetric and
      neonatal outcome. CONCLUSION: The addition of 50 or 100 mug morphine to 1.25mg
      bupivacaine and 5 mug sufentanil during established labour did not significantly 
      increase the duration of analgesia.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Hein, A
AU  - Hein A
AD  - Department of Anaesthesia & Intensive Care Medicine, Karolinska Institutet at
      Danderyd Hospital and Karolinska University Hospital, Stockholm, Sweden.
      anette.hein@ds.se
FAU - Rosblad, P
AU  - Rosblad P
FAU - Norman, M
AU  - Norman M
FAU - Ryniak, S
AU  - Ryniak S
FAU - Tingaker, B
AU  - Tingaker B
FAU - Jakobsson, J
AU  - Jakobsson J
FAU - Dahlgren, G
AU  - Dahlgren G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20100901
PL  - Netherlands
TA  - Int J Obstet Anesth
JT  - International journal of obstetric anesthesia
JID - 9200430
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Anesthetics, Local)
RN  - 0 (Oxytocics)
RN  - 50-56-6 (Oxytocin)
RN  - 76I7G6D29C (Morphine)
RN  - AFE2YW0IIZ (Sufentanil)
RN  - Y8335394RO (Bupivacaine)
SB  - IM
MH  - Adult
MH  - *Analgesia, Obstetrical
MH  - Analgesics, Opioid/*administration & dosage
MH  - *Anesthesia, Spinal
MH  - Anesthetics, Local/*administration & dosage
MH  - Bupivacaine/*administration & dosage
MH  - Double-Blind Method
MH  - Female
MH  - Heart Rate, Fetal
MH  - Humans
MH  - Injections, Spinal
MH  - Kaplan-Meier Estimate
MH  - Morphine/*administration & dosage
MH  - Oxytocics/therapeutic use
MH  - Oxytocin/therapeutic use
MH  - Pain Measurement
MH  - Pregnancy
MH  - Sufentanil/*administration & dosage
MH  - Young Adult
EDAT- 2010/09/04 06:00
MHDA- 2011/01/22 06:00
CRDT- 2010/09/04 06:00
PHST- 2010/01/17 00:00 [received]
PHST- 2010/04/02 00:00 [accepted]
PHST- 2010/09/04 06:00 [entrez]
PHST- 2010/09/04 06:00 [pubmed]
PHST- 2011/01/22 06:00 [medline]
AID - S0959-289X(10)00051-8 [pii]
AID - 10.1016/j.ijoa.2010.04.003 [doi]
PST - ppublish
SO  - Int J Obstet Anesth. 2010 Oct;19(4):384-9. doi: 10.1016/j.ijoa.2010.04.003. Epub 
      2010 Sep 1.


PMID- 20812658
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20100903
IS  - 0025-7818 (Print)
IS  - 0025-7818 (Linking)
VI  - 101
IP  - 3
DP  - 2010 May-Jun
TI  - [Consent and confidentiality in occupational health practice: balance between
      legal requirements and ethical values].
PG  - 163-8
AB  - INTRODUCTION: The recently introduced Italian law on the protection of workers'
      health states that the occupational health physician (competent physician) is
      required to act according to the Code of Ethics of the International Commission
      on Occupational Health (ICOH). AIM: This paper aims at examining the articles of 
      legislative decree 81/2008 dealing with informed consent and confidentiality
      compared with the corresponding points of the ICOH Ethics Code. RESULTS: Analysis
      of the relationship between articles 25 and 39 (informed consent) and 18, 20 and 
      39 (confidentiality) of the decree shows that there are some points of
      disagreement between the legal requirements and the Code of Ethics, in particular
      concerning prescribed health surveillance, consent based on appropriate
      information (points 8, 10 and 12 of the Code) and some aspects of confidentiality
      (points 10, 20, 21, 22 and 23 of the Code). CONCLUSION: Although the competent
      physician is required to act according to the law, the decisional process could
      lead to a violation of workers' autonomy.
FAU - Mora, Erika
AU  - Mora E
AD  - Cattedra e Scuola di Specializzazione di Medicina del lavoro, Universita di
      Modena e Reggio Emilia.
FAU - Franco, G
AU  - Franco G
LA  - ita
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
TT  - Consenso e confidenzialita nella pratica professionale del medico competente tra 
      requisiti normativi e valori etici.
PL  - Italy
TA  - Med Lav
JT  - La Medicina del lavoro
JID - 0401176
SB  - IM
MH  - Confidentiality/*ethics/*legislation & jurisprudence
MH  - Humans
MH  - Informed Consent/*ethics/*legislation & jurisprudence
MH  - Italy
MH  - Occupational Medicine/*ethics/*legislation & jurisprudence
EDAT- 2010/09/04 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/09/04 06:00
PHST- 2010/09/04 06:00 [entrez]
PHST- 2010/09/04 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
PST - ppublish
SO  - Med Lav. 2010 May-Jun;101(3):163-8.


PMID- 20812567
OWN - NLM
STAT- MEDLINE
DCOM- 20100907
LR  - 20100903
IS  - 0023-7205 (Print)
IS  - 0023-7205 (Linking)
VI  - 107
IP  - 29-31
DP  - 2010 Jul 21-Aug 10
TI  - [When the patient can't consent to participation in a trial: the Ethics Review
      Board should take over the decision responsibility from the relatives].
PG  - 1787
FAU - Risberg, Bo
AU  - Risberg B
AD  - Goteborgs universitet. risberg@telia.com
LA  - swe
PT  - Journal Article
TT  - Nar patienten inte kan lamna sitt medgivande att inga i en studie:
      Etikprovningsnamnden bor ta over beslutsansvaret fran de anhoriga.
PL  - Sweden
TA  - Lakartidningen
JT  - Lakartidningen
JID - 0027707
SB  - IM
MH  - Aortic Aneurysm, Abdominal/surgery
MH  - Aortic Rupture/surgery
MH  - Ethics Committees
MH  - *Ethics, Research
MH  - Humans
MH  - *Informed Consent/ethics
MH  - Randomized Controlled Trials as Topic/ethics
MH  - Sweden
MH  - Third-Party Consent/ethics
EDAT- 2010/09/04 06:00
MHDA- 2010/09/09 06:00
CRDT- 2010/09/04 06:00
PHST- 2010/09/04 06:00 [entrez]
PHST- 2010/09/04 06:00 [pubmed]
PHST- 2010/09/09 06:00 [medline]
PST - ppublish
SO  - Lakartidningen. 2010 Jul 21-Aug 10;107(29-31):1787.


PMID- 20812553
OWN - NLM
STAT- MEDLINE
DCOM- 20101018
LR  - 20100903
IS  - 0945-1129 (Print)
IS  - 0945-1129 (Linking)
VI  - 63
IP  - 8
DP  - 2010 Aug
TI  - [Standardization of ethics committees in health care and nursing facilities:
      future perspectives for sustainable and effective counseling].
PG  - 486-9
FAU - Bleyer, Bernhard
AU  - Bleyer B
AD  - Akademie fur Berufe im Gesundheits- und Sozialwesen in Bayern sowie Akademischer 
      Rat, Universitat Regensburg. bernhard.bleyer@theologie.uni-r.de
LA  - ger
PT  - Journal Article
TT  - Standardisierung von Ethikkomitees in Gesundheits- und Pflegeeinrichtungen:
      Zukunftsperspektiven fur nachhaltige und effektive Beratung.
PL  - Germany
TA  - Pflege Z
JT  - Pflege Zeitschrift
JID - 9430463
MH  - Ethics Committees/*standards/*trends
MH  - Ethics Consultation/*standards/*trends
MH  - *Ethics, Nursing
MH  - Germany
MH  - Health Facilities/*ethics
MH  - Humans
MH  - Nursing Evaluation Research
MH  - Nursing Homes/*ethics
MH  - Quality Assurance, Health Care/*standards
EDAT- 2010/09/04 06:00
MHDA- 2010/10/19 06:00
CRDT- 2010/09/04 06:00
PHST- 2010/09/04 06:00 [entrez]
PHST- 2010/09/04 06:00 [pubmed]
PHST- 2010/10/19 06:00 [medline]
PST - ppublish
SO  - Pflege Z. 2010 Aug;63(8):486-9.


PMID- 20812525
OWN - NLM
STAT- MEDLINE
DCOM- 20100928
LR  - 20101116
IS  - 1096-9012 (Print)
IS  - 1096-9012 (Linking)
VI  - 55
IP  - 4
DP  - 2010 Jul-Aug
TI  - A lack of standardization: the basis for the ethical issues surrounding quality
      and performance reports.
PG  - 241-51
AB  - Consumers in the United States are taking advantage of the proliferation of
      publicly available, internet-based performance reports and quality appraisals of 
      health plans, healthcare organizations, hospitals, and physicians to aid in their
      healthcare decision making. However, these appraisal practices have given rise to
      controversy and debate over certain distinctive ethical issues. This article
      advocates a standardized ethical framework to guide current and future
      development and implementation of performance reports. This framework, which
      would resolve a number of the major issues, includes the following ethical
      principles to guide the practice of public reporting on the Internet and
      facilitate enhanced quality improvement in the healthcare industry: legitimacy,
      data integrity and quality, transparency, informed understanding, equity, privacy
      and confidentiality, collaboration, accountability, and evaluation and continuous
      improvement.
FAU - Suchy, Kirsten
AU  - Suchy K
AD  - University Of New Hampshire, Durham, USA. kbv22@unh.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Healthc Manag
JT  - Journal of healthcare management / American College of Healthcare Executives
JID - 9803529
EIN - J Healthc Manag. 2010 Sep-Oct;55(5):302
MH  - Disclosure/*ethics/*standards
MH  - Health Facilities
MH  - *Quality Assurance, Health Care
MH  - United States
EDAT- 2010/09/04 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/09/04 06:00
PHST- 2010/09/04 06:00 [entrez]
PHST- 2010/09/04 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
PST - ppublish
SO  - J Healthc Manag. 2010 Jul-Aug;55(4):241-51.


PMID- 20812467
OWN - NLM
STAT- MEDLINE
DCOM- 20100924
LR  - 20190823
IS  - 0036-8733 (Print)
IS  - 0036-8733 (Linking)
VI  - 303
IP  - 3
DP  - 2010 Sep
TI  - Undifferentiated ethics.
PG  - 18, 20
FAU - Lehrman, Sally
AU  - Lehrman S
LA  - eng
PT  - News
PL  - United States
TA  - Sci Am
JT  - Scientific American
JID - 0404400
SB  - IM
MH  - *Adult Stem Cells/cytology
MH  - *Bioethical Issues
MH  - Cell Differentiation
MH  - *Embryonic Stem Cells/cytology
MH  - Humans
MH  - Informed Consent
MH  - *Pluripotent Stem Cells/cytology
MH  - Skin/*cytology
MH  - Tissue Donors/ethics
EDAT- 2010/09/04 06:00
MHDA- 2010/09/25 06:00
CRDT- 2010/09/04 06:00
PHST- 2010/09/04 06:00 [entrez]
PHST- 2010/09/04 06:00 [pubmed]
PHST- 2010/09/25 06:00 [medline]
AID - 10.1038/scientificamerican0910-18 [doi]
PST - ppublish
SO  - Sci Am. 2010 Sep;303(3):18, 20. doi: 10.1038/scientificamerican0910-18.


PMID- 20811853
OWN - NLM
STAT- MEDLINE
DCOM- 20110210
LR  - 20211020
IS  - 0927-3042 (Print)
IS  - 0927-3042 (Linking)
VI  - 156
DP  - 2010
TI  - Whose future is it? Ethical family decision making about daughters' treatment in 
      the oncofertility context.
PG  - 429-45
LID - 10.1007/978-1-4419-6518-9_33 [doi]
FAU - Galvin, Kathleen M
AU  - Galvin KM
AD  - Department of Communication Studies, Northwestern University, Evanston, IL, USA. 
      k-galvin@northwestern.edu
FAU - Clayman, Marla L
AU  - Clayman ML
LA  - eng
GR  - K12HD055884/HD/NICHD NIH HHS/United States
GR  - RL1 HD058296/HD/NICHD NIH HHS/United States
GR  - RL1 HD058296-03/HD/NICHD NIH HHS/United States
GR  - 8UL1DE019587/DE/NIDCR NIH HHS/United States
GR  - K12 HD055884/HD/NICHD NIH HHS/United States
GR  - UL1 DE019587/DE/NIDCR NIH HHS/United States
GR  - UL1 DE019587-03/DE/NIDCR NIH HHS/United States
GR  - 5RL1HD058296/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United States
TA  - Cancer Treat Res
JT  - Cancer treatment and research
JID - 8008541
SB  - IM
MH  - *Decision Making
MH  - Family/*psychology
MH  - Female
MH  - Humans
MH  - Infertility, Female/etiology/*prevention & control
MH  - Neoplasms/complications/*therapy
MH  - Nuclear Family/*psychology
MH  - Reproductive Techniques, Assisted/*psychology
PMC - PMC3086488
MID - NIHMS283620
EDAT- 2010/09/03 06:00
MHDA- 2011/02/11 06:00
CRDT- 2010/09/03 06:00
PHST- 2010/09/03 06:00 [entrez]
PHST- 2010/09/03 06:00 [pubmed]
PHST- 2011/02/11 06:00 [medline]
AID - 10.1007/978-1-4419-6518-9_33 [doi]
PST - ppublish
SO  - Cancer Treat Res. 2010;156:429-45. doi: 10.1007/978-1-4419-6518-9_33.


PMID- 20811836
OWN - NLM
STAT- MEDLINE
DCOM- 20110210
LR  - 20211020
IS  - 0927-3042 (Print)
IS  - 0927-3042 (Linking)
VI  - 156
DP  - 2010
TI  - Participation in investigational fertility preservation research: a feminist
      research ethics approach.
PG  - 209-21
LID - 10.1007/978-1-4419-6518-9_16 [doi]
FAU - McGowan, Michelle L
AU  - McGowan ML
AD  - Department of Bioethics, Case Western Reserve University School of Medicine,
      Cleveland, OH, USA. michelle.mcgowan@case.edu
LA  - eng
GR  - RL1 HD058296/HD/NICHD NIH HHS/United States
GR  - RL1 HD058296-03/HD/NICHD NIH HHS/United States
GR  - 8UL1DE019587/DE/NIDCR NIH HHS/United States
GR  - UL1 DE019587/DE/NIDCR NIH HHS/United States
GR  - UL1 DE019587-03/DE/NIDCR NIH HHS/United States
GR  - 5RL1HD058296/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United States
TA  - Cancer Treat Res
JT  - Cancer treatment and research
JID - 8008541
SB  - IM
MH  - *Biomedical Research
MH  - *Cryopreservation
MH  - *Ethics, Medical
MH  - Female
MH  - *Feminism
MH  - Humans
MH  - Infertility, Female/*prevention & control
MH  - Neoplasms/complications/*psychology/therapy
MH  - *Patient Participation
PMC - PMC3071553
MID - NIHMS283559
EDAT- 2010/09/03 06:00
MHDA- 2011/02/11 06:00
CRDT- 2010/09/03 06:00
PHST- 2010/09/03 06:00 [entrez]
PHST- 2010/09/03 06:00 [pubmed]
PHST- 2011/02/11 06:00 [medline]
AID - 10.1007/978-1-4419-6518-9_16 [doi]
PST - ppublish
SO  - Cancer Treat Res. 2010;156:209-21. doi: 10.1007/978-1-4419-6518-9_16.


PMID- 20811835
OWN - NLM
STAT- MEDLINE
DCOM- 20110210
LR  - 20211020
IS  - 0927-3042 (Print)
IS  - 0927-3042 (Linking)
VI  - 156
DP  - 2010
TI  - Ethical dilemmas in oncofertility: an exploration of three clinical scenarios.
PG  - 195-208
LID - 10.1007/978-1-4419-6518-9_15 [doi]
FAU - Gracia, Clarisa R
AU  - Gracia CR
AD  - Department of Reproductive Endocrinology and Infertility, University of
      Pennsylvania, Philadelphia, PA, USA. cgracia@obgyn.upenn.edu
FAU - Gracia, Jorge J E
AU  - Gracia JJ
FAU - Chen, Shasha
AU  - Chen S
LA  - eng
GR  - RL1 HD058296/HD/NICHD NIH HHS/United States
GR  - RL1 HD058296-03/HD/NICHD NIH HHS/United States
GR  - 8UL1DE019587/DE/NIDCR NIH HHS/United States
GR  - UL1 DE019587/DE/NIDCR NIH HHS/United States
GR  - UL1 DE019587-03/DE/NIDCR NIH HHS/United States
GR  - 5RL1HD058296/HD/NICHD NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Cancer Treat Res
JT  - Cancer treatment and research
JID - 8008541
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Breast Neoplasms/complications/*therapy
MH  - Connective Tissue Diseases/complications/*therapy
MH  - Decision Making
MH  - *Ethics, Professional
MH  - Female
MH  - Hodgkin Disease/complications/*therapy
MH  - Humans
MH  - Infertility/etiology/*prevention & control
MH  - Ovary/transplantation
MH  - Tissue Preservation
PMC - PMC3086476
MID - NIHMS283553
EDAT- 2010/09/03 06:00
MHDA- 2011/02/11 06:00
CRDT- 2010/09/03 06:00
PHST- 2010/09/03 06:00 [entrez]
PHST- 2010/09/03 06:00 [pubmed]
PHST- 2011/02/11 06:00 [medline]
AID - 10.1007/978-1-4419-6518-9_15 [doi]
PST - ppublish
SO  - Cancer Treat Res. 2010;156:195-208. doi: 10.1007/978-1-4419-6518-9_15.


PMID- 20811761
OWN - NLM
STAT- MEDLINE
DCOM- 20110404
LR  - 20211020
IS  - 1248-9204 (Electronic)
IS  - 1248-9204 (Linking)
VI  - 14
IP  - 6
DP  - 2010 Dec
TI  - Advantages of new materials in fascia transversalis reinforcement for inguinal
      hernia repair.
PG  - 617-21
LID - 10.1007/s10029-010-0723-7 [doi]
AB  - PURPOSE: We investigated whether new absorbable materials can be used in the
      treatment of inguinal hernia with the same efficacy as the traditionally used
      polypropylene. METHODS: We compared local tissue inflammation and fibrous
      reaction, postoperative complications (bleeding, wound haematoma, wound
      infection) and postoperative recovery time (time of mobilisation) in rats
      (Fischer strain) after implantation of a polypropylene mesh (PPM) (Prolene,
      Ethicon, Bracknell, UK) or a dual component fibrin mesh (DCFM) (Tachosil,
      Nycomed, Marlow, UK), between the muscle layer and the fascia transversalis
      defect. We further compared direct hernia repair methods using Lichtenstein's
      operation in humans after implantation of either PPM or DCFM for fascia
      transversalis reinforcement regarding postoperative pain and complications, time 
      needed for patient mobilisation, and recurrence. RESULTS: The results show that
      implantation of DCFM in rats resulted in milder inflammatory response and thicker
      fibrous tissue formation. Patients implanted with DCFM had significantly lower
      postoperative pain scores on a visual-analogue scale and lower analgesic use. The
      overall incidence of postoperative complications was significantly reduced with
      the use of DCFM. The incidence of recurrence after 24-month follow-up was the
      same in both groups. CONCLUSION: This study has shown that DCFM has the same
      short-term efficacy in hernia treatment as the standard PPM, with a reduction in 
      postoperative pain and analgesic use, and a decrease in overall postoperative
      complications. In the rat model, DCFM resulted in milder inflammatory response
      and thicker fibrous plate than the PPM. Further biomechanical testing and longer 
      follow-up is necessary, but initial results are promising.
FAU - Arslani, N
AU  - Arslani N
AD  - Department of Surgery and Urology, Zabok General Hospital, Bracak 8, 49210,
      Zabok, Croatia. arslani.nuhi@gmail.com
FAU - Patrlj, L
AU  - Patrlj L
FAU - Kopljar, M
AU  - Kopljar M
FAU - Rajkovic, Z
AU  - Rajkovic Z
FAU - Altarac, S
AU  - Altarac S
FAU - Papes, D
AU  - Papes D
FAU - Stritof, D
AU  - Stritof D
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20100902
PL  - France
TA  - Hernia
JT  - Hernia : the journal of hernias and abdominal wall surgery
JID - 9715168
RN  - 0 (Polypropylenes)
SB  - IM
MH  - Absorbable Implants
MH  - Adult
MH  - Aged
MH  - Animals
MH  - Disease Models, Animal
MH  - *Fasciotomy
MH  - Female
MH  - Hernia, Inguinal/*surgery
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polypropylenes
MH  - Rats
MH  - Rats, Inbred F344
MH  - *Surgical Mesh
MH  - Wound Healing
EDAT- 2010/09/03 06:00
MHDA- 2011/04/05 06:00
CRDT- 2010/09/03 06:00
PHST- 2010/06/01 00:00 [received]
PHST- 2010/08/16 00:00 [accepted]
PHST- 2010/09/03 06:00 [entrez]
PHST- 2010/09/03 06:00 [pubmed]
PHST- 2011/04/05 06:00 [medline]
AID - 10.1007/s10029-010-0723-7 [doi]
PST - ppublish
SO  - Hernia. 2010 Dec;14(6):617-21. doi: 10.1007/s10029-010-0723-7. Epub 2010 Sep 2.


PMID- 20811619
OWN - NLM
STAT- MEDLINE
DCOM- 20101104
LR  - 20211020
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 5
IP  - 8
DP  - 2010 Aug 25
TI  - Thar she blows! A novel method for DNA collection from cetacean blow.
PG  - e12299
LID - 10.1371/journal.pone.0012299 [doi]
AB  - BACKGROUND: Molecular tools are now widely used to address crucial management and
      conservation questions. To date, dart biopsying has been the most commonly used
      method for collecting genetic data from cetaceans; however, this method has some 
      drawbacks. Dart biopsying is considered inappropriate for young animals and has
      recently come under scrutiny from ethical boards, conservationists, and the
      general public. Thus, identifying alternative genetic collection techniques for
      cetaceans remains a priority, especially for internationally protected species.
      METHODOLOGY/PRINCIPAL FINDINGS: In this study, we investigated whether
      blow-sampling, which involves collecting exhalations from the blowholes of
      cetaceans, could be developed as a new less invasive method for DNA collection.
      Our current methodology was developed using six bottlenose dolphins, Tursiops
      truncatus, housed at the National Aquarium, Baltimore (USA), from which we were
      able to collect both blow and blood samples. For all six individuals, we found
      that their mitochondrial and microsatellite DNA profile taken from blow, matched 
      their corresponding mitochondrial and microsatellite DNA profile collected from
      blood. This indicates that blow-sampling is a viable alternative method for DNA
      collection. CONCLUSION/SIGNIFICANCE: In this study, we show that blow-sampling
      provides a viable and less invasive method for collection of genetic data, even
      for small cetaceans. In contrast to dart biopsying, the advantage of this method 
      is that it capitalizes on the natural breathing behaviour of dolphins and can be 
      applied to even very young dolphins. Both biopsy and blow-sampling require close 
      proximity of the boat, but blow-sampling can be achieved when dolphins
      voluntarily bow-ride and involves no harmful contact.
FAU - Frere, Celine H
AU  - Frere CH
AD  - School of Veterinary Sciences, University of Queensland, Brisbane, Australia.
      c.frere@uq.edu.au
FAU - Krzyszczyk, Ewa
AU  - Krzyszczyk E
FAU - Patterson, Eric M
AU  - Patterson EM
FAU - Hunter, Sue
AU  - Hunter S
FAU - Ginsburg, Alison
AU  - Ginsburg A
FAU - Mann, Janet
AU  - Mann J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20100825
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (DNA, Mitochondrial)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Bottle-Nosed Dolphin/blood/*physiology
MH  - DNA/blood/genetics/*isolation & purification
MH  - DNA, Mitochondrial/blood/genetics/isolation & purification
MH  - *Exhalation
MH  - Female
MH  - Male
MH  - Microsatellite Repeats/genetics
MH  - Molecular Sequence Data
MH  - Specimen Handling/*methods
PMC - PMC2928266
EDAT- 2010/09/03 06:00
MHDA- 2010/11/05 06:00
CRDT- 2010/09/03 06:00
PHST- 2010/06/24 00:00 [received]
PHST- 2010/07/16 00:00 [accepted]
PHST- 2010/09/03 06:00 [entrez]
PHST- 2010/09/03 06:00 [pubmed]
PHST- 2010/11/05 06:00 [medline]
AID - 10.1371/journal.pone.0012299 [doi]
PST - epublish
SO  - PLoS One. 2010 Aug 25;5(8):e12299. doi: 10.1371/journal.pone.0012299.


PMID- 20811241
OWN - NLM
STAT- MEDLINE
DCOM- 20101004
LR  - 20211020
IS  - 1529-4242 (Electronic)
IS  - 0032-1052 (Linking)
VI  - 126
IP  - 3
DP  - 2010 Sep
TI  - A systematic review of the relationship between plastic surgery and the medical
      industry.
PG  - 1098-1105
LID - 10.1097/PRS.0b013e3181e60569 [doi]
AB  - BACKGROUND: The nature and extent of medicine's relationship with the medical
      industry is currently a heated issue in medicine. Although the ethical
      implications of this relationship have been widely discussed in medical journals 
      and the popular media, it is unknown how the current interest in industry issues 
      has affected plastic surgery. The aim of this systematic review was to
      characterize the literature of the past two decades that examines plastic
      surgery's relationship with the medical industry. METHODS: Three medical
      databases were searched using plastic surgery and industry-related search terms. 
      The quality of selected articles was assessed by two reviewers. The specific data
      abstracted included the venue of the industry interaction discussed within the
      article: (1) physician education programs, (2) research partnerships, and (3)
      clinical settings. Within each of these categories, a comprehensive taxonomy was 
      created to categorize the thematic content of the articles' discussions. RESULTS:
      Of the 465 articles gleaned by the search, 21 met the inclusion and exclusion
      criteria and were included in the final review. All 21 articles were of a review 
      or editorial nature, and the majority (57 percent) discussed the nature or
      effects of industry's presence within the clinical setting. CONCLUSIONS: This
      systematic review revealed the literature's cursory analysis of plastic surgery's
      relationship with the medical industry. This project highlighted the need for
      plastic surgery to examine the ethical implications of industry's support and
      engagement within the field. Improving this literature is necessary for plastic
      surgeons to understand and adhere to current standards on acceptable practices.
FAU - Clapham, Philip J
AU  - Clapham PJ
AD  - Ann Arbor, Mich. From the Section of Plastic Surgery, Department of Surgery,
      University of Michigan Health System.
FAU - Chung, Kevin C
AU  - Chung KC
LA  - eng
GR  - K24 AR053120/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PT  - Systematic Review
PL  - United States
TA  - Plast Reconstr Surg
JT  - Plastic and reconstructive surgery
JID - 1306050
SB  - IM
MH  - *Industry
MH  - *Interdisciplinary Communication
MH  - *Surgery, Plastic
MH  - United States
RF  - 39
PMC - PMC4386574
MID - NIHMS676659
EDAT- 2010/09/03 06:00
MHDA- 2010/10/05 06:00
CRDT- 2010/09/03 06:00
PHST- 2010/09/03 06:00 [entrez]
PHST- 2010/09/03 06:00 [pubmed]
PHST- 2010/10/05 06:00 [medline]
AID - 10.1097/PRS.0b013e3181e60569 [doi]
AID - 00006534-201009000-00045 [pii]
PST - ppublish
SO  - Plast Reconstr Surg. 2010 Sep;126(3):1098-1105. doi:
      10.1097/PRS.0b013e3181e60569.


PMID- 20811223
OWN - NLM
STAT- MEDLINE
DCOM- 20101004
LR  - 20210106
IS  - 1529-4242 (Electronic)
IS  - 0032-1052 (Linking)
VI  - 126
IP  - 3
DP  - 2010 Sep
TI  - Ethical considerations in the first American face transplant.
PG  - 896-901
LID - 10.1097/PRS.0b013e3181e3b63d [doi]
AB  - BACKGROUND: Before performing the first face transplant in the United States, the
      authors addressed several ethical considerations: subject selection, adequacy of 
      informed consent, and risk-to-benefit analysis. METHODS: Destruction of the
      patient's midface, including its bony architecture, had impaired the ability of
      the authors' patient to speak, eat, smell, and socialize. These functional
      impairments and the inability of conventional reconstruction to reconstruct this 
      deformity justified considering this patient for face transplantation. The
      patient's resilience in adapting to her injury, her conscientious self-care
      following her initial injury, and her ability to understand the risks and
      uncertainties of the proposed procedure were important factors in selecting her
      as a candidate for this innovation. To enhance our patient's understanding of
      this largely untried procedure, the informed consent process occurred over
      multiple encounters involving both information disclosure and assessment of
      comprehension of what the procedure involved, including its potential benefits
      and risks. The patient demonstrated not only understanding of the procedure,
      including its innovative nature and concomitant uncertainties, but also that its 
      goals were consistent with her values. RESULTS: Research risk-to-benefit analysis
      involved balancing societal and subject benefits against subject risks. The
      potential benefit to society and increased knowledge of the role of face
      transplantation in facial reconstruction were substantial. The subject's benefits
      had been maximized and harms minimized through subject selection, team expertise,
      and preparation. This produced a risk-to-benefit profile in which we considered
      that the benefits sufficiently outweighed the risks to proceed with
      transplantation in this patient. CONCLUSION: Ethical considerations were
      important determinants in the decision to proceed with facial transplantation in 
      this woman.
FAU - Paradis, Carmen
AU  - Paradis C
AD  - Cleveland, Ohio From the Cleveland Clinic.
FAU - Siemionow, Maria
AU  - Siemionow M
FAU - Papay, Francis
AU  - Papay F
FAU - Lohman, Robert
AU  - Lohman R
FAU - Kodish, Eric
AU  - Kodish E
FAU - Gordon, Chad
AU  - Gordon C
FAU - Djohan, Risal
AU  - Djohan R
FAU - Coffman, Kathy
AU  - Coffman K
FAU - Bernard, Steven
AU  - Bernard S
FAU - Alam, Daniel
AU  - Alam D
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Plast Reconstr Surg
JT  - Plastic and reconstructive surgery
JID - 1306050
SB  - IM
MH  - Facial Transplantation/*ethics
MH  - Humans
MH  - Informed Consent
MH  - Patient Selection
MH  - United States
EDAT- 2010/09/03 06:00
MHDA- 2010/10/05 06:00
CRDT- 2010/09/03 06:00
PHST- 2010/09/03 06:00 [entrez]
PHST- 2010/09/03 06:00 [pubmed]
PHST- 2010/10/05 06:00 [medline]
AID - 10.1097/PRS.0b013e3181e3b63d [doi]
AID - 00006534-201009000-00021 [pii]
PST - ppublish
SO  - Plast Reconstr Surg. 2010 Sep;126(3):896-901. doi: 10.1097/PRS.0b013e3181e3b63d.


PMID- 20810963
OWN - NLM
STAT- MEDLINE
DCOM- 20101215
LR  - 20211020
IS  - 1931-7913 (Electronic)
IS  - 1931-7913 (Linking)
VI  - 9
IP  - 3
DP  - 2010 Fall
TI  - Preparing the "new" biologist of the future: student research at the interface of
      mathematics and biology.
PG  - 311-5
LID - 10.1187/cbe.10-03-0025 [doi]
AB  - We describe a unique Research Experience for Undergraduates and Research
      Experience for Veterinary students summer program at the National Institute for
      Mathematical and Biological Synthesis on the campus of the University of
      Tennessee, Knoxville. The program focused on interdisciplinary research at the
      interface of biology and mathematics. Participants were selected to work on
      projects with a biology mentor and a mathematics mentor in an environment that
      promoted collaboration outside of the students' respective disciplines. There
      were four research projects with teams of four participants and two faculty
      mentors. The participants consisted of a mixture of 10 undergraduates in biology-
      and mathematics-related disciplines, four veterinary students, and two
      high-school teachers. The activities included lectures on both the biological and
      mathematical backgrounds of the projects, tutorials for software, and sessions on
      ethics, graduate school, and possible career paths for individuals interested in 
      biology and mathematics. The program was designed to give students the ability to
      actively participate in the scientific research process by working on a project, 
      writing up their results in a final report, and presenting their work orally. We 
      report on the results of our evaluation surveys of the participants.
FAU - Duncan, Sarah I
AU  - Duncan SI
AD  - National Institute for Mathematical and Biological Synthesis, University of
      Tennessee, Knoxville, TN 37996, USA. sduncan7@utk.edu
FAU - Bishop, Pamela
AU  - Bishop P
FAU - Lenhart, Suzanne
AU  - Lenhart S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - CBE Life Sci Educ
JT  - CBE life sciences education
JID - 101269039
SB  - IM
MH  - Biology/*education
MH  - Humans
MH  - Knowledge
MH  - Mathematics/*education
MH  - Program Evaluation
MH  - Research/*education
MH  - *Students
MH  - Surveys and Questionnaires
PMC - PMC2931678
EDAT- 2010/09/03 06:00
MHDA- 2010/12/16 06:00
CRDT- 2010/09/03 06:00
PHST- 2010/09/03 06:00 [entrez]
PHST- 2010/09/03 06:00 [pubmed]
PHST- 2010/12/16 06:00 [medline]
AID - 9/3/311 [pii]
AID - 10.1187/cbe.10-03-0025 [doi]
PST - ppublish
SO  - CBE Life Sci Educ. 2010 Fall;9(3):311-5. doi: 10.1187/cbe.10-03-0025.


PMID- 20810697
OWN - NLM
STAT- MEDLINE
DCOM- 20110119
LR  - 20161020
IS  - 1526-3347 (Electronic)
IS  - 0191-9601 (Linking)
VI  - 31
IP  - 9
DP  - 2010 Sep
TI  - Ethics for the pediatrician: pediatrician/patient/parent relationships.
PG  - e65-7
LID - 10.1542/pir.31-9-e65 [doi]
FAU - Ladd, Rosalind Ekman
AU  - Ladd RE
AD  - Professor of Philosophy Emerita, Wheaton College, Wheaton, Ill, USA.
FAU - Forman, Edwin N
AU  - Forman EN
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Pediatr Rev
JT  - Pediatrics in review
JID - 8103046
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child Advocacy/*ethics
MH  - Communication
MH  - Cystic Fibrosis/therapy
MH  - Family Conflict/ethics
MH  - Female
MH  - Hockey/*injuries
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Intubation, Intratracheal
MH  - Knee Injuries/rehabilitation
MH  - Parent-Child Relations
MH  - Pediatrics/*ethics
MH  - Professional-Family Relations/*ethics
MH  - Respiration, Artificial/ethics
MH  - United States
EDAT- 2010/09/03 06:00
MHDA- 2011/01/20 06:00
CRDT- 2010/09/03 06:00
PHST- 2010/09/03 06:00 [entrez]
PHST- 2010/09/03 06:00 [pubmed]
PHST- 2011/01/20 06:00 [medline]
AID - 31/9/e65 [pii]
AID - 10.1542/pir.31-9-e65 [doi]
PST - ppublish
SO  - Pediatr Rev. 2010 Sep;31(9):e65-7. doi: 10.1542/pir.31-9-e65.


PMID- 20810583
OWN - NLM
STAT- MEDLINE
DCOM- 20110105
LR  - 20170123
IS  - 1557-9700 (Electronic)
IS  - 1075-2730 (Linking)
VI  - 61
IP  - 9
DP  - 2010 Sep
TI  - Focus on patient management: responsibly managing psychiatric inpatient refusal
      of medical or surgical diagnostic work-up.
PG  - 868-70
LID - 10.1176/ps.2010.61.9.868 [doi]
AB  - This column uses the tools of normative ethics-analysis and argument-to provide a
      reasoned account of and to identify ethically justified responses by the
      psychiatrist to psychiatric inpatients' refusal of medical or surgical diagnostic
      work-up. There are three relevant ethical considerations when psychiatric
      inpatients refuse medical or surgical diagnostic tests: balancing autonomy with
      beneficence, surrogate decision making and confidentiality, and managing strong
      feelings. Assisted decision making and assent are key management strategies for
      promoting patients' autonomy and for protecting against adverse consequences of
      decision making.
FAU - Swindell, J S
AU  - Swindell JS
AD  - Center for Medical Ethics and Health Policy, Baylor College of Medicine, MS 420, 
      Houston, TX 77007, USA. jsswinde@bcm.edu
FAU - Coverdale, John H
AU  - Coverdale JH
FAU - Crisp-Han, Holly
AU  - Crisp-Han H
FAU - McCullough, Laurence B
AU  - McCullough LB
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Psychiatr Serv
JT  - Psychiatric services (Washington, D.C.)
JID - 9502838
SB  - IM
MH  - Confidentiality
MH  - Decision Making
MH  - Diagnostic Tests, Routine/*psychology
MH  - Humans
MH  - Inpatients/*psychology
MH  - Mental Disorders
MH  - Patient Care Management/*ethics
MH  - Physician-Patient Relations/*ethics
MH  - Proxy
MH  - *Treatment Refusal
EDAT- 2010/09/03 06:00
MHDA- 2011/01/06 06:00
CRDT- 2010/09/03 06:00
PHST- 2010/09/03 06:00 [entrez]
PHST- 2010/09/03 06:00 [pubmed]
PHST- 2011/01/06 06:00 [medline]
AID - 61/9/868 [pii]
AID - 10.1176/ps.2010.61.9.868 [doi]
PST - ppublish
SO  - Psychiatr Serv. 2010 Sep;61(9):868-70. doi: 10.1176/ps.2010.61.9.868.


PMID- 20809709
OWN - NLM
STAT- MEDLINE
DCOM- 20100924
LR  - 20131121
IS  - 1933-0715 (Electronic)
IS  - 1933-0707 (Linking)
VI  - 6
IP  - 3
DP  - 2010 Sep
TI  - Care of pediatric neurosurgical patients in Iraq in 2007: clinical and ethical
      experience of a field hospital.
PG  - 250-6
LID - 10.3171/2010.6.PEDS1031 [doi]
AB  - OBJECT: Care for host-nation pediatric casualties and disease or nonbattle
      injuries is an essential mission of deployed military medical assets. Clinical
      experience with pediatric patients at field hospitals has been increasingly
      reported since 2001, with neurotrauma identified as a major cause of morbidity
      and death in this population. A concentrated pediatric neurosurgical experience
      at a deployed medical facility has not been reported. The authors reviewed their 
      experience with pediatric neurosurgical patients at a field hospital in Iraq in
      2007 to provide insight into the management of this patient population. METHODS: 
      A retrospective review was conducted using a prospective database constructed by 
      the authors for quality improvement during a single combat rotation in 2007.
      RESULTS: Forty-two patients among 287 consultations were 17 years of age or
      younger. Twenty-six of these children were 8 years old or younger. Penetrating
      head injuries were the most common indication for consultation (22 of 42
      patients). Twenty-eight of 130 surgical procedures were performed in the
      children. One patient died in the perioperative period, for a trauma-related
      operative mortality rate of 4%. Seven patients received palliative care based on 
      the extent of presenting injuries. Twenty-five patients were discharged with
      minimal or no neurological deficits. CONCLUSIONS: Pediatric patients represent a 
      significant proportion of the neurosurgical patient volume at field medical
      hospitals in the Iraqi theater. The mature medical theater environment present in
      2007 allowed for remarkable diagnostic evaluation and treatment of these
      patients. Penetrating and closed craniospinal injuries were the most common
      indication for consultation. Disease and nonbattle injuries were also
      encountered, with care provided when deemed appropriate. The deployed environment
      presents unique medical and ethical challenges to neurosurgeons serving in
      forward medical facilities.
FAU - Martin, Jonathan E
AU  - Martin JE
AD  - Department of Surgery, Division of Neurosurgery, University of Connecticut School
      of Medicine, Connecticut Children's Medical Center, Hartford, Connecticut 06106, 
      USA. jmartin03@ccmckids.org
FAU - Teff, Richard J
AU  - Teff RJ
FAU - Spinella, Philip C
AU  - Spinella PC
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Neurosurg Pediatr
JT  - Journal of neurosurgery. Pediatrics
JID - 101463759
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Emergency Medical Services
MH  - Female
MH  - Head Injuries, Penetrating/mortality/*surgery
MH  - Hospitals, Military
MH  - Humans
MH  - Iran
MH  - Iraq War, 2003-2011
MH  - Male
MH  - Patient Care/standards
MH  - Retrospective Studies
MH  - Spinal Injuries/mortality/surgery
EDAT- 2010/09/03 06:00
MHDA- 2010/09/25 06:00
CRDT- 2010/09/03 06:00
PHST- 2010/09/03 06:00 [entrez]
PHST- 2010/09/03 06:00 [pubmed]
PHST- 2010/09/25 06:00 [medline]
AID - 10.3171/2010.6.PEDS1031 [doi]
PST - ppublish
SO  - J Neurosurg Pediatr. 2010 Sep;6(3):250-6. doi: 10.3171/2010.6.PEDS1031.


PMID- 20809281
OWN - NLM
STAT- MEDLINE
DCOM- 20110228
LR  - 20211020
IS  - 1435-1269 (Electronic)
IS  - 0948-6704 (Linking)
VI  - 43
IP  - 5
DP  - 2010 Oct
TI  - [Living and dying in community based housing for people with dementia. An
      exploratory qualitative study].
PG  - 285-90
LID - 10.1007/s00391-010-0140-7 [doi]
AB  - Community based housing for people with dementia is gaining importance. In
      co-operation between the people concerned, their relatives, professionals and
      volunteers, person-centred care, nursing and guidance can be realised within
      small units. Questions regarding end of life, dying, grief and the role of
      palliative care form the basis of the exploratory qualitative study presented
      here. Coping with end of life, ethical decisions and the relevance of hospice and
      palliative care in the field are highlighted. The results of the study show that 
      "shared flats for people with dementia" are good places for death and dying.
      Close relationships, good communication with relatives and highly motivated
      professionals can be regarded as powerful resources. So far only few
      co-operations between hospice and palliative care exist. Areas of improvement
      encompass clinical issues and coping with bereavement.
FAU - Reitinger, E
AU  - Reitinger E
AD  - IFF - Palliative Care und OrganisationsEthik, Alpen-Adria-Universitat Klagenfurt,
      Schottenfeldgasse 29/4, 1070 Wien, Osterreich. elisabeth.reitinger@uni-klu.ac.at
FAU - Pleschberger, S
AU  - Pleschberger S
FAU - Schumann, F
AU  - Schumann F
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Leben und Sterben in Wohngemeinschaften fur Menschen mit Demenz. Eine explorative
      qualitative Studie.
PL  - Germany
TA  - Z Gerontol Geriatr
JT  - Zeitschrift fur Gerontologie und Geriatrie
JID - 9506215
SB  - IM
MH  - Adaptation, Psychological
MH  - Aged
MH  - Aged, 80 and over
MH  - Dementia/*mortality/*nursing/psychology
MH  - Ethics, Professional
MH  - Female
MH  - Grief
MH  - Group Homes/*ethics
MH  - Homes for the Aged/*ethics
MH  - Hospice Care/*ethics
MH  - Humans
MH  - Male
MH  - Palliative Care/*ethics
MH  - Patient-Centered Care/ethics
MH  - Professional-Family Relations
EDAT- 2010/09/03 06:00
MHDA- 2011/03/01 06:00
CRDT- 2010/09/03 06:00
PHST- 2010/09/03 06:00 [entrez]
PHST- 2010/09/03 06:00 [pubmed]
PHST- 2011/03/01 06:00 [medline]
AID - 10.1007/s00391-010-0140-7 [doi]
PST - ppublish
SO  - Z Gerontol Geriatr. 2010 Oct;43(5):285-90. doi: 10.1007/s00391-010-0140-7.


PMID- 20807915
OWN - NLM
STAT- MEDLINE
DCOM- 20101222
LR  - 20190709
IS  - 1943-4723 (Electronic)
IS  - 0002-8177 (Linking)
VI  - 141
IP  - 9
DP  - 2010 Sep
TI  - What ethical issues should general dentists consider when the state of the
      economy affects decisions regarding referral of patients to specialists?
PG  - 1125-6
FAU - Wentworth, Rod B
AU  - Wentworth RB
AD  - American Dental Association Council on Ethics, Bylaws and Judicial Affairs, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Am Dent Assoc
JT  - Journal of the American Dental Association (1939)
JID - 7503060
SB  - IM
MH  - *Economic Recession
MH  - *Ethics, Dental
MH  - General Practice, Dental/economics/*ethics
MH  - Humans
MH  - Referral and Consultation/*ethics
MH  - Specialties, Dental/ethics
EDAT- 2010/09/03 06:00
MHDA- 2010/12/24 06:00
CRDT- 2010/09/03 06:00
PHST- 2010/09/03 06:00 [entrez]
PHST- 2010/09/03 06:00 [pubmed]
PHST- 2010/12/24 06:00 [medline]
AID - 141/9/1125 [pii]
AID - 10.14219/jada.archive.2010.0345 [doi]
PST - ppublish
SO  - J Am Dent Assoc. 2010 Sep;141(9):1125-6. doi: 10.14219/jada.archive.2010.0345.


PMID- 20807853
OWN - NLM
STAT- MEDLINE
DCOM- 20110331
LR  - 20100902
IS  - 1535-5675 (Electronic)
IS  - 0091-4916 (Linking)
VI  - 38
IP  - 3
DP  - 2010 Sep
TI  - Ethical issues in radioisotope shortages: rationing and priority setting.
PG  - 117-20
LID - 10.2967/jnmt.110.081117 [doi]
AB  - In recent years, shortages of radioisotopes that cannot be stockpiled have
      created a scenario in which they may be considered, periodically, a scarce
      medical resource. This discussion focuses on the just allocation of medical
      radioisotopes and presents the dominant ethical frameworks for rationing and
      priority setting in the patient populations most affected. Priority setting is
      necessary when demand for a scarce resource exceeds supply. On completion of this
      article, the reader will be able to describe the origins of rationing and
      priority setting in medicine, as well as ethically sound frameworks for
      rationing. Finally, the process for priority setting and the need for
      transparency of this process in the nuclear medicine setting are outlined.
FAU - Rosenthal, M Sara
AU  - Rosenthal MS
AD  - Program for Bioethics, Department of Internal Medicine, University of Kentucky,
      Lexington, Kentucky 40536-0284, USA. msrose2@email.uky.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Nucl Med Technol
JT  - Journal of nuclear medicine technology
JID - 0430303
RN  - 0 (Radioisotopes)
SB  - IM
MH  - Health Care Rationing/*ethics/statistics & numerical data
MH  - Humans
MH  - Nuclear Medicine/ethics
MH  - Radioisotopes/*supply & distribution
EDAT- 2010/09/03 06:00
MHDA- 2011/04/01 06:00
CRDT- 2010/09/03 06:00
PHST- 2010/09/03 06:00 [entrez]
PHST- 2010/09/03 06:00 [pubmed]
PHST- 2011/04/01 06:00 [medline]
AID - 38/3/117 [pii]
AID - 10.2967/jnmt.110.081117 [doi]
PST - ppublish
SO  - J Nucl Med Technol. 2010 Sep;38(3):117-20. doi: 10.2967/jnmt.110.081117.


PMID- 20807851
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 257
IP  - 2
DP  - 2010 Nov
TI  - Computer-aided detection of lung cancer on chest radiographs: effect on observer 
      performance.
PG  - 532-40
LID - 10.1148/radiol.10092437 [doi]
AB  - PURPOSE: To assess how computer-aided detection (CAD) affects reader performance 
      in detecting early lung cancer on chest radiographs. MATERIALS AND METHODS: In
      this ethics committee-approved study, 46 individuals with 49 computed
      tomographically (CT)-detected and histologically proved lung cancers and 65
      patients without nodules at CT were retrospectively included. All subjects
      participated in a lung cancer screening trial. Chest radiographs were obtained
      within 2 months after screening CT. Four radiology residents and two experienced 
      radiologists were asked to identify and localize potential cancers on the chest
      radiographs, first without and subsequently with the use of CAD software. A
      figure of merit was calculated by using free-response receiver operating
      characteristic analysis. RESULTS: Tumor diameter ranged from 5.1 to 50.7 mm
      (median, 11.8 mm). Fifty-one percent (22 of 49) of lesions were subtle and
      detected by two or fewer readers. Stand-alone CAD sensitivity was 61%, with an
      average of 2.4 false-positive annotations per chest radiograph. Average
      sensitivity was 63% for radiologists at 0.23 false-positive annotations per chest
      radiograph and 49% for residents at 0.45 false-positive annotations per chest
      radiograph. Figure of merit did not change significantly for any of the observers
      after using CAD. CAD marked between five and 16 cancers that were initially
      missed by the readers. These correctly CAD-depicted lesions were rejected by
      radiologists in 92% of cases and by residents in 77% of cases. CONCLUSION: The
      sensitivity of CAD in identifying lung cancers depicted with CT screening was
      similar to that of experienced radiologists. However, CAD did not improve cancer 
      detection because, especially for subtle lesions, observers were unable to
      sufficiently differentiate true-positive from false-positive annotations.
CI  - (c) RSNA, 2010.
FAU - de Hoop, Bartjan
AU  - de Hoop B
AD  - Department of Radiology and Image Sciences Institute, University Medical Center, 
      Heidelberglaan 100, 3584 CX, Utrecht, the Netherlands. b.j.dehoop@umcutrecht.nl
FAU - De Boo, Diederik W
AU  - De Boo DW
FAU - Gietema, Hester A
AU  - Gietema HA
FAU - van Hoorn, Frans
AU  - van Hoorn F
FAU - Mearadji, Banafsche
AU  - Mearadji B
FAU - Schijf, Laura
AU  - Schijf L
FAU - van Ginneken, Bram
AU  - van Ginneken B
FAU - Prokop, Mathias
AU  - Prokop M
FAU - Schaefer-Prokop, Cornelia
AU  - Schaefer-Prokop C
LA  - eng
PT  - Journal Article
DEP - 20100831
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
CIN - Radiologe. 2011 Apr;51(4):263. PMID: 21487959
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/*diagnostic imaging
MH  - Male
MH  - Middle Aged
MH  - Observer Variation
MH  - ROC Curve
MH  - *Radiographic Image Interpretation, Computer-Assisted
MH  - Radiography, Thoracic/*methods
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - Software
MH  - *Tomography, X-Ray Computed
EDAT- 2010/09/03 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/09/03 06:00
PHST- 2010/09/03 06:00 [entrez]
PHST- 2010/09/03 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - radiol.10092437 [pii]
AID - 10.1148/radiol.10092437 [doi]
PST - ppublish
SO  - Radiology. 2010 Nov;257(2):532-40. doi: 10.1148/radiol.10092437. Epub 2010 Aug
      31.


PMID- 20807634
OWN - NLM
STAT- MEDLINE
DCOM- 20110107
LR  - 20151119
IS  - 1531-6564 (Electronic)
IS  - 0363-5023 (Linking)
VI  - 35
IP  - 9
DP  - 2010 Sep
TI  - Ethics and professionalism for hand surgeons.
PG  - 1554-5
LID - 10.1016/j.jhsa.2010.06.022 [doi]
FAU - Rayan, Ghazi
AU  - Rayan G
AD  - Division of Hand Surgery, INTEGRIS Baptist Medical Center, Oklahoma City, OK,
      USA. ouhsgmr@aol.com
FAU - Glickel, Steve
AU  - Glickel S
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Hand Surg Am
JT  - The Journal of hand surgery
JID - 7609631
SB  - IM
MH  - Clinical Competence
MH  - Ethics, Medical
MH  - Expert Testimony
MH  - Female
MH  - General Surgery/*ethics/standards
MH  - Hand/*surgery
MH  - Humans
MH  - Interprofessional Relations
MH  - Male
MH  - Physician-Patient Relations
MH  - Practice Patterns, Physicians'/*ethics
MH  - *Professional Competence
MH  - Quality Assurance, Health Care
MH  - United States
EDAT- 2010/09/03 06:00
MHDA- 2011/01/08 06:00
CRDT- 2010/09/03 06:00
PHST- 2010/06/11 00:00 [received]
PHST- 2010/06/19 00:00 [accepted]
PHST- 2010/09/03 06:00 [entrez]
PHST- 2010/09/03 06:00 [pubmed]
PHST- 2011/01/08 06:00 [medline]
AID - S0363-5023(10)00772-0 [pii]
AID - 10.1016/j.jhsa.2010.06.022 [doi]
PST - ppublish
SO  - J Hand Surg Am. 2010 Sep;35(9):1554-5. doi: 10.1016/j.jhsa.2010.06.022.


PMID- 20807378
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110504
LR  - 20110104
IS  - 1539-6924 (Electronic)
IS  - 0272-4332 (Linking)
VI  - 31
IP  - 1
DP  - 2011 Jan
TI  - Strategic appraisal of environmental risks: a contrast between the United
      Kingdom's Stern Review on the Economics of Climate Change and its Committee on
      Radioactive Waste Management.
PG  - 129-42
LID - 10.1111/j.1539-6924.2010.01484.x [doi]
AB  - In this article, we compare two high-profile strategic policy reviews undertaken 
      for the U.K. government on environmental risks: radioactive waste management and 
      climate change. These reviews took very different forms, both in terms of
      analytic approach and deliberation strategy. The Stern Review on the Economics of
      Climate Change was largely an exercise in expert modeling, building, within a
      cost-benefit framework, an argument for immediate reductions in carbon emissions.
      The Committee on Radioactive Waste Management, on the other hand, followed a much
      more explicitly deliberative and participative process, using multicriteria
      decision analysis to bring together scientific evidence and stakeholder and
      public values. In this article, we ask why the two reviews were different, and
      whether the differences are justified. We conclude that the differences were
      mainly due to political context, rather than the underpinning science, and as a
      consequence that, while in our view "fit for purpose," they would both have been 
      stronger had they been less different. Stern's grappling with ethical issues
      could have been strengthened by a greater degree of public and stakeholder
      engagement, and the Committee on Radioactive Waste Management's handling of
      issues of uncertainty could have been strengthened by the explicitly
      probabilistic framework of Stern.
CI  - (c) 2010 Society for Risk Analysis.
FAU - Dietz, Simon
AU  - Dietz S
AD  - London School of Economics and Political Science, Houghton Street, London
      WC2A2AE, UK.
FAU - Morton, Alec
AU  - Morton A
LA  - eng
PT  - Journal Article
DEP - 20100830
PL  - United States
TA  - Risk Anal
JT  - Risk analysis : an official publication of the Society for Risk Analysis
JID - 8109978
EDAT- 2010/09/03 06:00
MHDA- 2010/09/03 06:01
CRDT- 2010/09/03 06:00
PHST- 2010/09/03 06:00 [entrez]
PHST- 2010/09/03 06:00 [pubmed]
PHST- 2010/09/03 06:01 [medline]
AID - RISK1484 [pii]
AID - 10.1111/j.1539-6924.2010.01484.x [doi]
PST - ppublish
SO  - Risk Anal. 2011 Jan;31(1):129-42. doi: 10.1111/j.1539-6924.2010.01484.x. Epub
      2010 Aug 30.


PMID- 20807257
OWN - NLM
STAT- MEDLINE
DCOM- 20110502
LR  - 20220410
IS  - 1468-2494 (Electronic)
IS  - 0142-5463 (Linking)
VI  - 33
IP  - 1
DP  - 2011 Feb
TI  - Infant skin physiology and development during the first years of life: a review
      of recent findings based on in vivo studies.
PG  - 17-24
LID - 10.1111/j.1468-2494.2010.00611.x [doi]
AB  - Infant skin is often presented as the cosmetic ideal for adults. However,
      compared to adult skin it seems to be more prone to develop certain pathological 
      conditions, such as atopic dermatitis and irritant contact dermatitis. Therefore,
      understanding the physiology of healthy infant skin as a point of reference is of
      interest both from the cosmetic as well as from the clinical point of view.
      Clinical research on healthy infants is, however, limited because of ethical
      considerations of using invasive methods and therefore until recently data has
      been scarce. Technical innovations and the availability of non-invasive in vivo
      techniques, such as evaporimetry, electrical impedance measurement, in vivo video
      and confocal microscopy, and in vivo fibre-optic based spectroscopy, opened up
      the field of in vivo infant skin physiology research. Studies incorporating such 
      methods have demonstrated that compared to adult, infant skin continues to
      develop during the first years of life. Specifically, infant skin appears to have
      thinner epidermis and stratum corneum (SC) as well as smaller corneocytes at
      least until the second year of life. The water-handling properties are not fully 
      developed before the end of the first year and infant SC contains more water and 
      less amounts of natural moisturizing factors. Such findings re-evaluate the old
      notions that skin is fully matured at birth. Armed with this knowledge, we are in
      a position not only to better understand infant dermatological conditions but
      also to design better skin care products respecting the distinct qualities of
      infant skin.
CI  - (c) 2010 The Authors. ICS (c) 2010 Society of Cosmetic Scientists and the Societe
      Francaise de Cosmetologie.
FAU - Stamatas, G N
AU  - Stamatas GN
AD  - Johnson & Johnson Consumer France, 1 rue Camille Desmoulins, Issy-les-Moulineaux,
      France. gstamata@its.jnj.com
FAU - Nikolovski, J
AU  - Nikolovski J
FAU - Mack, M C
AU  - Mack MC
FAU - Kollias, N
AU  - Kollias N
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100830
PL  - England
TA  - Int J Cosmet Sci
JT  - International journal of cosmetic science
JID - 8007161
SB  - IM
MH  - Humans
MH  - Infant
MH  - *Skin Physiological Phenomena
EDAT- 2010/09/03 06:00
MHDA- 2011/05/03 06:00
CRDT- 2010/09/03 06:00
PHST- 2010/09/03 06:00 [entrez]
PHST- 2010/09/03 06:00 [pubmed]
PHST- 2011/05/03 06:00 [medline]
AID - ICS611 [pii]
AID - 10.1111/j.1468-2494.2010.00611.x [doi]
PST - ppublish
SO  - Int J Cosmet Sci. 2011 Feb;33(1):17-24. doi: 10.1111/j.1468-2494.2010.00611.x.
      Epub 2010 Aug 30.


PMID- 20807230
OWN - NLM
STAT- MEDLINE
DCOM- 20110531
LR  - 20181201
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 11
IP  - 1
DP  - 2011 Apr
TI  - A question of justice: assessing nurse migration from a philosophical
      perspective.
PG  - 30-9
LID - 10.1111/j.1471-8847.2010.00284.x [doi]
AB  - The intensified nurse migration leads to severe problems for the health care
      systems in many developing countries. Using the Philippines as an example, this
      paper will address the question of global nurse migration from a philosophical
      perspective. John Rawls' liberal and Michael Walzer's communitarian theory of
      justice will be examined in view of the ethical problem of nurse migration. In
      line with Rawls' A Theory of Justice, nurse migration undermines the ability of
      the people in developing countries to make use of their basic rights and
      liberties. Walzer's communitarian assessment of nurse migration, on the other
      hand, will stress the shared 'thin' morality, as well as the shared history
      between the 'donating' and receiving countries. This paper argues that the
      commonality of a shared history and common values implies the moral obligation to
      ensure a fairer distribution of nurses.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Kaelin, Lukas
AU  - Kaelin L
AD  - Institute for Ethics and Law in Medicine, Spitalgasse 2-4, Vienna, Austria.
      lukas.kaelin@univie.ac.at
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100827
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
SB  - IM
MH  - *Developed Countries
MH  - *Developing Countries
MH  - *Emigration and Immigration
MH  - Female
MH  - *Health Workforce/ethics/trends
MH  - Humans
MH  - Internationality
MH  - *Nurses
MH  - Philippines
MH  - *Social Justice
MH  - Social Responsibility
MH  - United States
EDAT- 2010/09/03 06:00
MHDA- 2011/06/01 06:00
CRDT- 2010/09/03 06:00
PHST- 2010/09/03 06:00 [entrez]
PHST- 2010/09/03 06:00 [pubmed]
PHST- 2011/06/01 06:00 [medline]
AID - DEWB284 [pii]
AID - 10.1111/j.1471-8847.2010.00284.x [doi]
PST - ppublish
SO  - Dev World Bioeth. 2011 Apr;11(1):30-9. doi: 10.1111/j.1471-8847.2010.00284.x.
      Epub 2010 Aug 27.


PMID- 20807019
OWN - NLM
STAT- MEDLINE
DCOM- 20110614
LR  - 20220224
IS  - 1477-2566 (Electronic)
IS  - 1465-3249 (Linking)
VI  - 12
IP  - 8
DP  - 2010 Dec
TI  - Reversal of experimental diabetes in mice by transplantation of neo-islets
      generated from human amnion-derived mesenchymal stromal cells using
      immuno-isolatory macrocapsules.
PG  - 982-91
LID - 10.3109/14653249.2010.509546 [doi]
AB  - BACKGROUND AIMS: The ethical and biologic limitations with current sources of
      stem cells have resulted in a quest to look for alternative sources of
      multipotent stem cells of human origin. Amniotic membrane is of interest as a
      source of cells for regenerative medicine because of its ease of availability,
      plasticity and inexhaustible source that does not violate the sanctity of
      independent life. Although researchers have shown the stem cell-like potential of
      human amniotic epithelial cells, the mesenchymal part of amnion has remained less
      explored. METHODS: We established a long-term culture of mesenchymal-like stem
      cells derived from full-term human amniotic membrane and their differentiation
      into functional pancreatic lineage. RESULTS: The amnion-derived mesenchymal-like 
      stem cells expressed various mesenchymal markers and demonstrated multilineage
      differentiation capacity. We also observed that these cells could form islet-like
      clusters (ILC) on exposure to serum-free defined media containing specific growth
      factor and differentiating agents. Differentiated ILC showed expression of human 
      insulin, glucagon and somatostatin by immunocytochemistry, while quantitative
      reverse transcription/real-time-polymerase chain reaction (qRT-PCR) data
      demonstrated the expression of insulin, glucagon, somatostatin, Ngn3 and Isl1.
      Moreover, encapsulation of the ILC in polyurethane-polyvinyl pyrrolidone
      macrocapsules and their subsequent transplantation in experimental diabetic mice 
      resulted in restoration of normoglycemia, indicating their ability to respond to 
      high glucose without immunorejection. CONCLUSIONS: Our results demonstrate that
      amnion-derived mesenchymal stromal cells can undergo islet neogenesis, indicating
      amnion as an alternative source of islets for cell replacement therapy in
      diabetes.
FAU - Kadam, Sachin S
AU  - Kadam SS
AD  - Tissue Engineering and Banking Laboratory, National Center for Cell Science,
      Pune, India.
FAU - Sudhakar, M
AU  - Sudhakar M
FAU - Nair, Prabha D
AU  - Nair PD
FAU - Bhonde, Ramesh R
AU  - Bhonde RR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100831
PL  - England
TA  - Cytotherapy
JT  - Cytotherapy
JID - 100895309
RN  - 0 (Capsules)
RN  - 0 (Polyurethanes)
RN  - FZ989GH94E (Povidone)
SB  - IM
MH  - Amnion/*cytology
MH  - Animals
MH  - Capsules/chemistry/therapeutic use
MH  - Cell Differentiation
MH  - Cell Proliferation
MH  - Cell Separation
MH  - Cells, Cultured
MH  - Diabetes Mellitus, Experimental/immunology/pathology/*therapy
MH  - Graft Rejection/*immunology/prevention & control
MH  - Humans
MH  - Islets of Langerhans/cytology/*metabolism
MH  - Male
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Mesenchymal Stem Cells/cytology/*metabolism
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Polyurethanes/chemistry/metabolism
MH  - Povidone/chemistry/metabolism
MH  - Stromal Cells/cytology/*metabolism
MH  - Transplantation, Heterologous
EDAT- 2010/09/03 06:00
MHDA- 2011/06/15 06:00
CRDT- 2010/09/03 06:00
PHST- 2010/09/03 06:00 [entrez]
PHST- 2010/09/03 06:00 [pubmed]
PHST- 2011/06/15 06:00 [medline]
AID - 10.3109/14653249.2010.509546 [doi]
AID - S1465-3249(10)70467-9 [pii]
PST - ppublish
SO  - Cytotherapy. 2010 Dec;12(8):982-91. doi: 10.3109/14653249.2010.509546. Epub 2010 
      Aug 31.


PMID- 20807009
OWN - NLM
STAT- MEDLINE
DCOM- 20110317
LR  - 20200429
IS  - 1619-3997 (Electronic)
IS  - 0300-5577 (Linking)
VI  - 38
IP  - 6
DP  - 2010 Nov
TI  - Ethical dimensions of periviability.
PG  - 579-83
LID - 10.1515/jpm.2010.098 [doi]
AB  - The birth of neonates at the limits of viability, or periviability, poses
      numerous challenges to health care providers and to systems of care, and the care
      of these pregnancies and neonates is fraught with ethical controversies. This
      statement summarizes the ethical principles involved in the care of periviable
      pregnancies and neonates, and provides expert clinical opinion about the numerous
      challenges posed by this problem around the world. Topics addressed include a
      summary of the published experience, an ethical framework, translating neonatal
      outcome data to the obstetric arena, management as a trial of intervention,
      referral to tertiary centers, neonatal resuscitation, cesarean delivery for fetal
      indication, and limits on life-sustaining neonatal treatment.
FAU - Skupski, Daniel W
AU  - Skupski DW
AD  - Department of Obstetrics and Gynecology, Weill Cornell Medical Center, New York, 
      NY 10021, USA. dwskupsk@med.cornell.edu
FAU - Chervenak, Frank A
AU  - Chervenak FA
FAU - McCullough, Laurence B
AU  - McCullough LB
FAU - Bancalari, Eduardo
AU  - Bancalari E
FAU - Haumont, Dominique
AU  - Haumont D
FAU - Simeoni, Umberto
AU  - Simeoni U
FAU - Saugstad, Ola
AU  - Saugstad O
FAU - Donn, Steven
AU  - Donn S
FAU - Arabin, Birgit
AU  - Arabin B
FAU - Greenough, Anne
AU  - Greenough A
FAU - Donzelli, Gianpaolo
AU  - Donzelli G
FAU - Levene, Malcolm
AU  - Levene M
FAU - Sen, Cihat
AU  - Sen C
FAU - Carbonell, Xavier
AU  - Carbonell X
FAU - Dudenhausen, Joachim W
AU  - Dudenhausen JW
FAU - Vladareanu, Radu
AU  - Vladareanu R
FAU - Antsaklis, Aris
AU  - Antsaklis A
FAU - Papp, Zoltan
AU  - Papp Z
FAU - Aksit, Mehmet
AU  - Aksit M
FAU - Carrapato, Manuel
AU  - Carrapato M
LA  - eng
PT  - Journal Article
DEP - 20100831
PL  - Germany
TA  - J Perinat Med
JT  - Journal of perinatal medicine
JID - 0361031
SB  - IM
MH  - Decision Making/*ethics
MH  - *Ethics, Medical
MH  - Female
MH  - *Fetal Viability
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Pregnancy
EDAT- 2010/09/03 06:00
MHDA- 2011/03/18 06:00
CRDT- 2010/09/03 06:00
PHST- 2010/09/03 06:00 [entrez]
PHST- 2010/09/03 06:00 [pubmed]
PHST- 2011/03/18 06:00 [medline]
AID - 10.1515/jpm.2010.098 [doi]
PST - ppublish
SO  - J Perinat Med. 2010 Nov;38(6):579-83. doi: 10.1515/jpm.2010.098. Epub 2010 Aug
      31.


PMID- 20806841
OWN - NLM
STAT- MEDLINE
DCOM- 20100929
LR  - 20211020
IS  - 0026-6620 (Print)
IS  - 0026-6620 (Linking)
VI  - 107
IP  - 4
DP  - 2010 Jul-Aug
TI  - Pharmacotherapeutic approach to the treatment of addiction: persistent
      challenges.
PG  - 276-80
AB  - The sequence of pathophysiological responses to repeated self-administration of
      addictive compounds is briefly described, as are prospects for development of
      drugs for addiction and some of those currently available. It is noted that the
      varying vulnerability of individuals to addictions creates ethical concerns
      regarding the application of drug abuse pharmacotherapies as they become more
      efficacious. It is noted further that relapse remains the most persistent
      challenge in the treatment of addictions.
FAU - Zahm, Daniel S
AU  - Zahm DS
AD  - Department of Pharmacological and Physiological Science, Saint Louis University
      School of Medicine, USA. zahmds@slu.edu
LA  - eng
GR  - R01 NS023805/NS/NINDS NIH HHS/United States
GR  - R01 NS023805-21/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Mo Med
JT  - Missouri medicine
JID - 0400744
RN  - 0 (Alcohol Deterrents)
RN  - 0 (GABA Agents)
RN  - 0 (Narcotic Antagonists)
SB  - IM
MH  - Alcohol Deterrents/therapeutic use
MH  - Behavior, Addictive/drug therapy
MH  - GABA Agents/therapeutic use
MH  - Humans
MH  - Narcotic Antagonists/therapeutic use
MH  - Secondary Prevention
MH  - Substance-Related Disorders/*drug therapy/prevention & control/psychology
RF  - 29
PMC - PMC2964348
MID - NIHMS242136
EDAT- 2010/09/03 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/09/03 06:00
PHST- 2010/09/03 06:00 [entrez]
PHST- 2010/09/03 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
PST - ppublish
SO  - Mo Med. 2010 Jul-Aug;107(4):276-80.


PMID- 20806565
OWN - NLM
STAT- MEDLINE
DCOM- 20100929
LR  - 20100901
IS  - 1660-9379 (Print)
IS  - 1660-9379 (Linking)
VI  - 6
IP  - 257
DP  - 2010 Jul 28
TI  - [Health in prison: shared vulnerability between detainees and health
      professionals].
PG  - 1462-5
AB  - In prison, the health professional has to take the sanitary needs of a temporary 
      of chronically vulnerable population. His practice has to meet laws and
      recommendations, as well as the field reality and its numerous constraints. This 
      puts him in a "shared vulnerability and stigmatization". He attempts to maintain 
      or restore a health status in a deteriorating environment, at least
      psychologically. He is in the penitentiary world's eye which he depends upon in
      many ways to achieve his mandate. His activity is scarcely known and recognised
      by his peers from whom he can be very out of touch. To ensure a humanistic,
      efficient and equivalent-of-care practice, the health professional must rely on
      sound knowledge of general healthcare, ethics, deontology and medical laws. Basic
      and continuous training is a mainspring, like networking and development of
      federal recommendations.
FAU - Rieder, J P
AU  - Rieder JP
AD  - Service de Medecine de Premier Recours, Unite de Medecine Penitentiaire,
      Department de Medecine Communautaire et de premier recours, HUG, Geneve.
      jean-pierre.rieder@hcuge.ch
FAU - Gravier, B
AU  - Gravier B
FAU - Bertrand, D
AU  - Bertrand D
FAU - Pasche, C
AU  - Pasche C
FAU - Bodenmann, P
AU  - Bodenmann P
FAU - Wolff, H
AU  - Wolff H
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Sante en milieu penitentiaire: vulnerabilite partagee entre detenus et
      professionnels de la sante.
PL  - Switzerland
TA  - Rev Med Suisse
JT  - Revue medicale suisse
JID - 101219148
SB  - IM
MH  - *Health Services Needs and Demand
MH  - Humans
MH  - *Physician's Role
MH  - *Prisoners
EDAT- 2010/09/02 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/09/02 06:00
PHST- 2010/09/02 06:00 [entrez]
PHST- 2010/09/02 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
PST - ppublish
SO  - Rev Med Suisse. 2010 Jul 28;6(257):1462-5.


PMID- 20806522
OWN - NLM
STAT- MEDLINE
DCOM- 20100929
LR  - 20191210
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 7
IP  - 3
DP  - 2010 Jul-Sep
TI  - Ethical issues in child and adolescent psychotherapy: a clinical review.
PG  - 157-61
AB  - Child and adolescent psychotherapy has made great progress in recent years. With 
      this progress, ethical issues have emerged that need to be addressed in the
      Indian setting. This article looks at various ethical issues in child and
      adolescent psychotherapy specific to Indian practitioners. The involvement of
      parents in psychotherapy often blurs therapeutic boundaries and issues related to
      confidentiality. Practitioners working in hospital and school settings are faced 
      with similar problems. The advent of the internet and e-mail has resulted in new 
      concerns for psychiatrists, related to communication via those media. Issues
      related to parenting, culture and development patterns, along with personal
      issues for the therapist, have been discussed.
FAU - de Sousa, Avinash
AU  - de Sousa A
AD  - Carmel, 18, St Francis Avenue,Off S V Road, Santa Cruz (W), Mumbai 400 054,
      India. avinashdes999@yahoo.co.uk
LA  - eng
PT  - Journal Article
PT  - Review
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Confidentiality/ethics
MH  - Cross-Cultural Comparison
MH  - Humans
MH  - India
MH  - Parents
MH  - Personal Autonomy
MH  - Professional-Patient Relations/ethics
MH  - Psychotherapy/*ethics
MH  - Transference, Psychology
MH  - Western World
RF  - 25
EDAT- 2010/09/02 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/09/02 06:00
PHST- 2010/09/02 06:00 [entrez]
PHST- 2010/09/02 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - 10.20529/IJME.2010.053 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2010 Jul-Sep;7(3):157-61. doi: 10.20529/IJME.2010.053.


PMID- 20806520
OWN - NLM
STAT- MEDLINE
DCOM- 20100929
LR  - 20181201
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 7
IP  - 3
DP  - 2010 Jul-Sep
TI  - Ethics in human resource management: potential for burnout among healthcare
      workers in ART and community care centres.
PG  - 146-51
AB  - This paper examines ethical dilemmas in providing care for people with HIV/AIDS. 
      Healthcare providers in this sector are overworked, particularly in the high
      prevalence states. They are faced with the dual burden of the physical and the
      emotional risks of providing this care. The emotional risks result from their
      inability to control their work environment, while having to deal with the social
      and cultural dimensions of patients' experiences. The physical risk is addressed 
      to some extent by post exposure prophylaxis. But the emotional risk is largely
      left to the individual and there is little by way of institutional responsibility
      for minimising this. The guidelines for training workers in care and support
      programmes do not include any detailed institutional mechanisms for reducing
      workplace stress. This aspect of the programme needs to be examined for its
      ethical justification. The omission of institutional mechanisms to reduce the
      emotional risks experienced by healthcare providers in the HIV/AIDS sector could 
      be a function of lack of coordination across different stakeholders in programme 
      development. This can be addressed in further formulations of the programme.
      Whatever the reasons may be for overlooking these needs, the ethics of this
      choice need to be carefully reviewed.
FAU - Mala, Ramanathan
AU  - Mala R
AD  - Achutha Menon Centre for Health Science Studies, Sree Chitra Tirunal Institute
      for Medical Science and Technology, Medical College PO, Thiruvananthapuram, 695
      011 India. mala@sctimst.ac.in
FAU - Santhosh, Kumar M
AU  - Santhosh KM
FAU - Anshul, Avijit
AU  - Anshul A
FAU - Aarthy, R
AU  - Aarthy R
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Adaptation, Psychological
MH  - Adult
MH  - Antiretroviral Therapy, Highly Active
MH  - Burnout, Professional/*prevention & control
MH  - *Community Health Centers/ethics/organization & administration
MH  - Female
MH  - Guideline Adherence
MH  - *HIV Infections/drug therapy/prevention & control
MH  - Health Policy
MH  - Humans
MH  - India
MH  - Inservice Training
MH  - Male
MH  - Personnel Staffing and Scheduling/*ethics/standards
MH  - Professional-Patient Relations
MH  - Workforce
MH  - *Workload
EDAT- 2010/09/02 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/09/02 06:00
PHST- 2010/09/02 06:00 [entrez]
PHST- 2010/09/02 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - 10.20529/IJME.2010.051 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2010 Jul-Sep;7(3):146-51. doi: 10.20529/IJME.2010.051.


PMID- 20806519
OWN - NLM
STAT- MEDLINE
DCOM- 20100929
LR  - 20181201
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 7
IP  - 3
DP  - 2010 Jul-Sep
TI  - Supreme Court judgment on medical interrogation: on the just use of science and
      the ethics of doctors' participation in criminal investigation.
PG  - 139-42
FAU - Jesani, Amar
AU  - Jesani A
LA  - eng
PT  - Editorial
PT  - Legal Case
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Criminal Law/ethics/*legislation & jurisprudence
MH  - Ethics, Medical
MH  - Forensic Medicine/*ethics/*legislation & jurisprudence
MH  - Human Rights/*legislation & jurisprudence
MH  - Humans
MH  - India
MH  - Physician's Role
MH  - Security Measures/ethics/*legislation & jurisprudence
MH  - Terrorism/*legislation & jurisprudence
MH  - Torture/legislation & jurisprudence
EDAT- 2010/09/02 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/09/02 06:00
PHST- 2010/09/02 06:00 [entrez]
PHST- 2010/09/02 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - 10.20529/IJME.2010.050 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2010 Jul-Sep;7(3):139-42. doi: 10.20529/IJME.2010.050.


PMID- 20805701
OWN - NLM
STAT- MEDLINE
DCOM- 20101223
LR  - 20211020
IS  - 1662-8063 (Electronic)
IS  - 1662-4246 (Linking)
VI  - 13
IP  - 6
DP  - 2010
TI  - Research ethics in the era of personalized medicine: updating science's contract 
      with society.
PG  - 378-84
LID - 10.1159/000319473 [doi]
AB  - With the completed sequence of the human genome has come the prospect of
      substantially improving the quality of life for millions through personalized
      medicine approaches. Still, any advances in this direction require research
      involving human subjects. For decades science and ethics have enjoyed an
      allegiance reflected in a common set of ethical principles and procedures guiding
      the conduct of research with human subjects. Some of these principles emphasize
      avoiding harm over maximizing benefit. In this paper we revisit the priority
      given to these ethical principles - particularly the principles that support a
      cautious approach to science - and propose a reframing of the 'social contract'
      between science and society that emphasizes reciprocity and meeting public needs.
FAU - Meslin, Eric M
AU  - Meslin EM
AD  - Indiana University Center for Bioethics, IU School of Medicine, Indianapolis,
      Ind. 46202, USA. emeslin@iupui.edu
FAU - Cho, Mildred K
AU  - Cho MK
LA  - eng
GR  - P50 HG003389/HG/NHGRI NIH HHS/United States
GR  - UL1 RR025761/RR/NCRR NIH HHS/United States
GR  - UL1RR025761-01/RR/NCRR NIH HHS/United States
GR  - U54 RR024374-01A1/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20100831
PL  - Switzerland
TA  - Public Health Genomics
JT  - Public health genomics
JID - 101474167
SB  - IM
MH  - *Ethics, Research
MH  - Human Genome Project
MH  - Humans
MH  - *Precision Medicine
MH  - *Societies
PMC - PMC2951727
EDAT- 2010/09/02 06:00
MHDA- 2010/12/25 06:00
CRDT- 2010/09/01 06:00
PHST- 2010/04/08 00:00 [received]
PHST- 2010/06/25 00:00 [accepted]
PHST- 2010/09/01 06:00 [entrez]
PHST- 2010/09/02 06:00 [pubmed]
PHST- 2010/12/25 06:00 [medline]
AID - 000319473 [pii]
AID - 10.1159/000319473 [doi]
PST - ppublish
SO  - Public Health Genomics. 2010;13(6):378-84. doi: 10.1159/000319473. Epub 2010 Aug 
      31.


PMID- 20805544
OWN - NLM
STAT- MEDLINE
DCOM- 20101026
LR  - 20211020
IS  - 1942-5546 (Electronic)
IS  - 0025-6196 (Linking)
VI  - 85
IP  - 10
DP  - 2010 Oct
TI  - Ethical decision making with end-of-life care: palliative sedation and
      withholding or withdrawing life-sustaining treatments.
PG  - 949-54
LID - 10.4065/mcp.2010.0201 [doi]
AB  - Palliative sedation (PS) is the use of medications to induce decreased or absent 
      awareness in order to relieve otherwise intractable suffering at the end of life.
      Although uncommon, some patients undergoing aggressive symptom control measures
      still have severe suffering from underlying disease or therapy-related adverse
      effects. In these circumstances, use of PS is considered. Although the goal is to
      provide relief in an ethically acceptable way to the patient, family, and health 
      care team, health care professionals often voice concerns whether such treatment 
      is necessary or whether such treatment equates to physician-assisted suicide or
      euthanasia. In this review, we frame clinical scenarios in which PS may be
      considered, summarize the ethical underpinnings of the practice, and further
      differentiate PS from other forms of end-of-life care, including withholding
      and/or withdrawing life-sustaining therapy and physician-assisted suicide and
      euthanasia.
FAU - Olsen, Molly L
AU  - Olsen ML
AD  - Division of General Internal Medicine, Palliative Medicine Program, Mayo Clinic, 
      200 First St SW, Rochester, MN 55905, USA.
FAU - Swetz, Keith M
AU  - Swetz KM
FAU - Mueller, Paul S
AU  - Mueller PS
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100830
PL  - England
TA  - Mayo Clin Proc
JT  - Mayo Clinic proceedings
JID - 0405543
SB  - IM
MH  - Conscious Sedation/ethics/*methods
MH  - Decision Making/*ethics
MH  - *Ethics, Medical
MH  - Humans
MH  - Palliative Care/ethics/*methods
MH  - Withholding Treatment/*ethics
PMC - PMC2947968
EDAT- 2010/09/02 06:00
MHDA- 2010/10/27 06:00
CRDT- 2010/09/01 06:00
PHST- 2010/09/01 06:00 [entrez]
PHST- 2010/09/02 06:00 [pubmed]
PHST- 2010/10/27 06:00 [medline]
AID - S0025-6196(11)60237-1 [pii]
AID - 10.4065/mcp.2010.0201 [doi]
PST - ppublish
SO  - Mayo Clin Proc. 2010 Oct;85(10):949-54. doi: 10.4065/mcp.2010.0201. Epub 2010 Aug
      30.


PMID- 20804881
OWN - NLM
STAT- MEDLINE
DCOM- 20100928
LR  - 20220330
IS  - 1558-1357 (Electronic)
IS  - 0029-6465 (Linking)
VI  - 45
IP  - 3
DP  - 2010 Sep
TI  - "I want to live, until I don't want to live anymore": involving children with
      life-threatening and life-shortening illnesses in decision making about care and 
      treatment.
PG  - 329-43
LID - 10.1016/j.cnur.2010.03.004 [doi]
AB  - Pediatric societies in North America and in the United Kingdom and Europe take
      the position that children should be part of the decision-making process. Less
      clear, however, is how that should be accomplished. This article outlines what
      needs to be considered when taking on the challenge of involving children with
      life-threatening and life-limiting illnesses in decision making regarding care
      and treatment and suggests an approach to involving children that recognizes
      their abilities, vulnerabilities, and relationships with others while at the same
      time ensuring an ethical and meaningful role for children.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Bluebond-Langner, Myra
AU  - Bluebond-Langner M
AD  - Department of Sociology, Anthropology and Criminal Justice, Rutgers University,
      405-407 Cooper Street, Camden, NJ 08102, USA. bluebond@camden.rutgers.edu
FAU - Belasco, Jean Bello
AU  - Belasco JB
FAU - DeMesquita Wander, Marla
AU  - DeMesquita Wander M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Nurs Clin North Am
JT  - The Nursing clinics of North America
JID - 0042033
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child Development
MH  - Cystic Fibrosis/therapy
MH  - *Decision Making/ethics
MH  - Female
MH  - Humans
MH  - Male
MH  - Neoplasms/therapy
MH  - *Palliative Care/ethics
MH  - Parent-Child Relations
MH  - *Patient Participation
MH  - Patient Selection/ethics
MH  - *Physician-Patient Relations/ethics
MH  - Truth Disclosure/ethics
EDAT- 2010/09/02 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/09/01 06:00
PHST- 2010/09/01 06:00 [entrez]
PHST- 2010/09/02 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - S0029-6465(10)00030-7 [pii]
AID - 10.1016/j.cnur.2010.03.004 [doi]
PST - ppublish
SO  - Nurs Clin North Am. 2010 Sep;45(3):329-43. doi: 10.1016/j.cnur.2010.03.004.


PMID- 20804226
OWN - NLM
STAT- MEDLINE
DCOM- 20101210
LR  - 20100831
IS  - 1175-5652 (Print)
IS  - 1175-5652 (Linking)
VI  - 8
IP  - 5
DP  - 2010
TI  - Issues surrounding orphan disease and orphan drug policies in Europe.
PG  - 343-50
LID - 10.2165/11536990-000000000-00000 [doi]
AB  - An orphan disease is a disease with a very low prevalence. Although there are
      5000-7000 orphan diseases, only 50 orphan drugs (i.e. drugs developed to treat
      orphan diseases) were marketed in the EU by the end of 2008. In 2000, the EU
      implemented policies specifically designed to stimulate the development of orphan
      drugs. While decisions on orphan designation and the marketing authorization of
      orphan drugs are made at the EU level, decisions on drug reimbursement are made
      at the member state level. The specific features of orphan diseases and orphan
      drugs make them a high-priority issue for policy makers. The aim of this article 
      is to identify and discuss several issues surrounding orphan disease and drug
      policies in Europe. The present system of orphan designation allows for drugs for
      non-orphan diseases to be designated as orphan drugs. The economic factors
      underlying orphan designation can be questioned in some cases, as a low
      prevalence of a certain indication does not equal a low return on investment for 
      the drug across its indications. High-quality evidence about the clinical added
      value of orphan drugs is rarely available at the time of marketing authorization,
      due to the low number of patients. A balance must be struck between ethical and
      economic concerns. To this effect, there is a need to initiate a societal
      dialogue on this issue, to clarify what society wants and accepts in terms of
      ethical and economic consequences. The growing budgetary impact of orphan drugs
      puts pressure on drug expenditure. Indications can be extended for an orphan drug
      and the total prevalence across indications is not considered. Finally,
      cooperation needs to be fostered in the EU, particularly through a standardized
      approach to the creation and use of registries. These issues require further
      attention from researchers, policy makers, health professionals, patients,
      pharmaceutical companies and other stakeholders with a view to optimizing orphan 
      disease and drug policies in Europe.
FAU - Denis, Alain
AU  - Denis A
AD  - Yellow Window Management Consultants, Antwerp, Belgium.
FAU - Mergaert, Lut
AU  - Mergaert L
FAU - Fostier, Christel
AU  - Fostier C
FAU - Cleemput, Irina
AU  - Cleemput I
FAU - Simoens, Steven
AU  - Simoens S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - New Zealand
TA  - Appl Health Econ Health Policy
JT  - Applied health economics and health policy
JID - 101150314
SB  - IM
MH  - Europe/epidemiology
MH  - *Health Policy
MH  - Humans
MH  - Incidence
MH  - Orphan Drug Production/*economics
MH  - Prevalence
MH  - Rare Diseases/*drug therapy/economics/epidemiology
MH  - Registries
EDAT- 2010/09/02 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/09/01 06:00
PHST- 2010/09/01 06:00 [entrez]
PHST- 2010/09/02 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 5 [pii]
AID - 10.2165/11536990-000000000-00000 [doi]
PST - ppublish
SO  - Appl Health Econ Health Policy. 2010;8(5):343-50. doi:
      10.2165/11536990-000000000-00000.


PMID- 31051868
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1876-7982 (Electronic)
IS  - 1876-7982 (Linking)
VI  - 41
IP  - 3
DP  - 2010 Sep
TI  - Investigating Patient Wait Times for Daily Outpatient Radiotherapy Appointments
      (A Single-Centre Study).
PG  - 145-151
LID - S1939-8654(10)00049-4 [pii]
LID - 10.1016/j.jmir.2010.06.001 [doi]
AB  - INTRODUCTION: Patient satisfaction is an important indicator of quality in health
      care. Radiotherapy (RT) requires patients to attend daily treatment through
      outpatient appointments (OPA). Therefore, wait times (WT) for daily RT OPAs can
      have a significant impact on patient satisfaction. This study aims to quantify
      WTs associated with daily RT OPAs and investigate the cause of identified delays.
      METHODS: A total of 128 outpatients scheduled on eight different linear
      accelerators for RT were included in this ethics-approved study. Radiation
      therapists recorded the entry time (time patient entered the treatment room) for 
      each OPA over 10 consecutive treatment days. Where applicable, radiation
      therapists recorded the cause for appointment delays. Subsequently, WTs were
      calculated as the difference between the scheduled appointment time and the entry
      time. Subgroup analysis by time of appointment and anatomical treatment sites was
      performed. RESULTS: Mean WT +/- standard deviation (SD) was 7.2 +/- 27 min. for
      866 OPAs. A total of 382/866 (44%) OPAs were early or on time (-12 +/- 21 min.); 
      484/866 (56%) were delayed (22 +/- 20 min.). The delays were primarily attributed
      to an indirect cause of catching up from previous delayed appointments (73%). The
      WT was </=20 min. for 693/866 OPAs (80.0%). The mean WT +/- SD was longest for
      midday appointments (10:30 AM-2:30 PM) at 9.5 +/- 29 min. and was statistically
      significant (P = .020). The comparison of WTs by treatments sites showed pelvis
      site (majority prostate cancer patients) experiencing the longest WT +/- SD at 11
      +/- 22 min. (P < .0001), caused by specific radiotherapy treatment protocol.
      CONCLUSION: Most OPAs (80%) were treated within 20 min. of their scheduled time. 
      Reported delays were influenced by clinic workflow and coordination of multiple
      appointments throughout the day. The findings of this study will assist in the
      formulation of strategies to improve efficiency and patient satisfaction.
CI  - Crown Copyright (c) 2010. Published by Elsevier Inc. All rights reserved.
FAU - Chan, Kitty
AU  - Chan K
AD  - Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada.
      Electronic address: Kitty.Chan@rmp.uhn.on.ca.
FAU - Li, Winnie
AU  - Li W
AD  - Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada;
      Biostatistics Department, Princess Margaret Hospital, Toronto, Ontario, Canada.
FAU - Medlam, Gaylene
AU  - Medlam G
AD  - Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada.
FAU - Higgins, Jane
AU  - Higgins J
AD  - Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada;
      Biostatistics Department, Princess Margaret Hospital, Toronto, Ontario, Canada.
FAU - Bolderston, Amanda
AU  - Bolderston A
AD  - Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada;
      Biostatistics Department, Princess Margaret Hospital, Toronto, Ontario, Canada.
FAU - Yi, Qilong
AU  - Yi Q
AD  - Department of Radiation Oncology, Faculty of Medicine, University of Toronto,
      Ontario, Canada.
FAU - Wenz, Julie
AU  - Wenz J
AD  - Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada.
LA  - eng
PT  - Journal Article
DEP - 20110608
PL  - United States
TA  - J Med Imaging Radiat Sci
JT  - Journal of medical imaging and radiation sciences
JID - 101469694
OTO - NOTNLM
OT  - Outpatient clinic
OT  - Radiotherapy
OT  - Wait times
EDAT- 2010/09/01 00:00
MHDA- 2010/09/01 00:01
CRDT- 2019/05/05 06:00
PHST- 2010/02/12 00:00 [received]
PHST- 2010/06/01 00:00 [revised]
PHST- 2010/06/10 00:00 [accepted]
PHST- 2019/05/05 06:00 [entrez]
PHST- 2010/09/01 00:00 [pubmed]
PHST- 2010/09/01 00:01 [medline]
AID - S1939-8654(10)00049-4 [pii]
AID - 10.1016/j.jmir.2010.06.001 [doi]
PST - ppublish
SO  - J Med Imaging Radiat Sci. 2010 Sep;41(3):145-151. doi:
      10.1016/j.jmir.2010.06.001. Epub 2011 Jun 8.


PMID- 29776250
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1744-828X (Electronic)
IS  - 1741-0541 (Linking)
VI  - 7
IP  - 5
DP  - 2010 Sep
TI  - Towards a framework for personalized healthcare: lessons learned from the field
      of rare diseases.
PG  - 569-586
LID - 10.2217/pme.10.52 [doi]
AB  - A large percentage of medicines do not work for the patient populations they are 
      intended to treat. Increased knowledge regarding genomics and the underlying
      biological mechanism of diseases should help us be able to stratify patients into
      groups of likely responders and nonresponders, and to identify those patients for
      whom a treatment might do more harm than good. This article sets out different
      policy perspectives for the healthcare systems, and draws in on 25 years of
      particular experience from the rare disease and orphan drug field, to illuminate 
      the pathway forward in relation to key implementation aspects of personalized
      healthcare. In principle, we submit that targeting medicines to preidentified
      groups for whom we can predict a beneficial outcome is a good thing for everyone 
      - first of all for the patients, but also for all the other stakeholders,
      including payers, treating physicians and industry - because it has the potential
      to create sustainable and functioning healthcare systems directed to better
      health and prevention of disease. Personalized healthcare over time could also
      lead to shorter drug-development times because of lower rates of failure in
      late-stage drug development. Using orphan medicines to treat well-diagnosed
      patients suffering from a life-threatening or seriously debilitating rare
      disease, is an attempt to work according to these principles. As there is much
      that needs to be done to turn the promise into reality, we need to identify the
      barriers and challenges to transform the potential opportunities into real-life
      benefits, and what needs to be done in order to overcome them. Learning from the 
      field of rare diseases and orphan drugs may provide, perhaps unexpectedly, some
      of the answers to public policy questions related to future (personalized)
      healthcare, but of course not all aspects, are common between the two fields.
FAU - Tambuyzer, Erik
AU  - Tambuyzer E
AD  - Genzyme Belgium NV/SA, 53 Ikaroslaan, Zaventem, Belgium.
      erik.tambuyzer@genzyme.com.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Per Med
JT  - Personalized medicine
JID - 101238549
OTO - NOTNLM
OT  - biomarkers
OT  - business models
OT  - diagnostic testing
OT  - education
OT  - ethics
OT  - incentives
OT  - multistakeholder collaboration
OT  - orphan drugs
OT  - patients outcomes
OT  - personalized healthcare
OT  - pharmacogenomics
OT  - rare diseases
OT  - registries
OT  - regulatory framework
EDAT- 2010/09/01 00:00
MHDA- 2010/09/01 00:01
CRDT- 2018/05/20 06:00
PHST- 2018/05/20 06:00 [entrez]
PHST- 2010/09/01 00:00 [pubmed]
PHST- 2010/09/01 00:01 [medline]
AID - 10.2217/pme.10.52 [doi]
PST - ppublish
SO  - Per Med. 2010 Sep;7(5):569-586. doi: 10.2217/pme.10.52.


PMID- 29776243
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1744-828X (Electronic)
IS  - 1741-0541 (Linking)
VI  - 7
IP  - 5
DP  - 2010 Sep
TI  - Providers' behavioral beliefs regarding the delivery of genomic medicine at the
      Veterans Health Administration.
PG  - 485-494
LID - 10.2217/pme.10.47 [doi]
AB  - AIMS: To examine providers' behavioral intention toward the utilization of
      genomic services at the Veterans Health Administration (VHA; Washington, DC, USA)
      through the lens of the 'Theory of Planned Behavior'. The theory of planned
      behavior posits that individuals' behaviors (using genomic services) are driven
      by their behavioral intentions. Behavioral intentions is a function of: first,
      behavioral beliefs; second, normative beliefs, and third; control beliefs.
      MATERIALS & METHODS: Semi-structured interviews were conducted with 20 providers 
      working in different units at the South Texas Veterans Health Care System
      (STVHCS; TX USA). The interviews focused on assessing providers' behavioral
      beliefs, normative beliefs and control beliefs regarding the delivery of genomic 
      medicine at the STVHCS. Interview materials were tape recorded, transcribed and
      the content was analyzed using qualitative methods. RESULTS: All participating
      providers perceived genomic medicine to be an important area in medicine
      (behavioral beliefs). They agreed that the VHA has the necessary infrastructure
      to foster the delivery of genomic services. The majority of participants (n = 18;
      90%) agreed that primary care providers will play a major role in delivering
      genomic services. Providers indicated that referents' (other providers) opinions 
      about genomic services may affect their decisions about whether to utilize
      genomic services (normative beliefs). However, most providers (n = 17; 85%)
      raised concerns about the impact of using genomic services on the process of care
      (control beliefs). Participants indicated that additional training for providers 
      and patients, and decision support will facilitate the delivery of genomic
      services (control beliefs). Providers also identified three external barriers:
      first, uncertainty about genomic findings; second, coordination of care between
      primary care, specialists and genetic services (system level barriers); and third
      ethical issues associated with genomic information and services. CONCLUSION: Our 
      findings highlight several opportunities and challenges related to the delivery
      of genomic medicine at the VHA. The results suggest that strategies to address
      providers' concerns in the control beliefs domain may be necessary to enhance
      providers' utilization of genomic services in clinical practice.
FAU - Arar, Nedal
AU  - Arar N
AD  - ararn@uthscsa.edu.
FAU - Seo, Joann
AU  - Seo J
AD  - Division of Nephrology/Department of Medicine, University of Texas Health Science
      Center at San Antonio, Audie L Murphy Memorial Veterans Hospital, 7703 Floyd Curl
      Drive, San Antonio, TX, USA.
FAU - Abboud, Hanna E
AU  - Abboud HE
AD  - Division of Nephrology/Department of Medicine, University of Texas Health Science
      Center at San Antonio, Audie L Murphy Memorial Veterans Hospital, 7703 Floyd Curl
      Drive, San Antonio, TX, USA.
FAU - Parchman, Michael
AU  - Parchman M
AD  - Division of Nephrology/Department of Medicine, University of Texas Health Science
      Center at San Antonio, Audie L Murphy Memorial Veterans Hospital, 7703 Floyd Curl
      Drive, San Antonio, TX, USA.
FAU - Noel, Polly
AU  - Noel P
AD  - Division of Nephrology/Department of Medicine, University of Texas Health Science
      Center at San Antonio, Audie L Murphy Memorial Veterans Hospital, 7703 Floyd Curl
      Drive, San Antonio, TX, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Per Med
JT  - Personalized medicine
JID - 101238549
OTO - NOTNLM
OT  - Veterans Health Administration
OT  - behavioral intentions
OT  - genomic medicine
OT  - genomic services
OT  - theory of planned behavior
EDAT- 2010/09/01 00:00
MHDA- 2010/09/01 00:01
CRDT- 2018/05/20 06:00
PHST- 2018/05/20 06:00 [entrez]
PHST- 2010/09/01 00:00 [pubmed]
PHST- 2010/09/01 00:01 [medline]
AID - 10.2217/pme.10.47 [doi]
PST - ppublish
SO  - Per Med. 2010 Sep;7(5):485-494. doi: 10.2217/pme.10.47.


PMID- 29776240
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1744-828X (Electronic)
IS  - 1741-0541 (Linking)
VI  - 7
IP  - 5
DP  - 2010 Sep
TI  - Regulatory and ethical challenges of personalized medicine.
PG  - 465-468
LID - 10.2217/pme.10.49 [doi]
FAU - Torr-Brown, Sheryl R
AU  - Torr-Brown SR
AD  - Spirals Translational Sciences, 91 Spring Valley Road, Mystic, CT 06355, USA.
      srtorr@gmail.com.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Per Med
JT  - Personalized medicine
JID - 101238549
OTO - NOTNLM
OT  - FDA
OT  - commercial testing
OT  - ethics
OT  - genes
OT  - genetic testing
OT  - genetics
OT  - personalized medicine
OT  - regulation
OT  - regulatory
EDAT- 2010/09/01 00:00
MHDA- 2010/09/01 00:01
CRDT- 2018/05/20 06:00
PHST- 2018/05/20 06:00 [entrez]
PHST- 2010/09/01 00:00 [pubmed]
PHST- 2010/09/01 00:01 [medline]
AID - 10.2217/pme.10.49 [doi]
PST - ppublish
SO  - Per Med. 2010 Sep;7(5):465-468. doi: 10.2217/pme.10.49.


PMID- 25860633
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150413
LR  - 20150411
IS  - 1608-5906 (Print)
IS  - 1608-5906 (Linking)
VI  - 9
IP  - 3
DP  - 2010 Sep
TI  - African communalism and public health policies: the relevance ofindigenous
      concepts of personal identity to HIV/AIDS policies in Botswana.
PG  - 297-305
LID - 10.2989/16085906.2010.530187 [doi]
AB  - This article explores the possible relevance of African communalism to HIV/AIDS
      policies in Botswana and other parts of sub-Saharan Africa. We examine various
      interpretations of African communalism, which many consider to be the cardinal
      insight of African thought. We suggest several applications of this indigenous
      notion of personhood to HIV prevention in general and to routine HIV-testing
      policies in particular. This analysis demonstrates some of the ethical dilemmas
      and cultural complexities inherent in designing as well as implementing effective
      HIV-prevention programmes that strike a conscientious balance between protecting 
      individual freedoms and securing public health. Recovering past traditions (such 
      as African conceptions of personal identity) is valuable not only for the purpose
      of self-identification but also for helping us meet the challenges and problems
      of today in Africa. We also suggest that the human-rights-based approach to HIV
      prevention, which strives to protect individuals, is possibly incompatible with
      the socio-ethical ideals espoused by African communalism. We conclude that public
      health programmes in Botswana and other parts of sub-Saharan Africa would be more
      effective if those who designed and implemented them possessed a better
      understanding of indigenous conceptions of personhood or human agency as well as 
      existing ethno-medical beliefs and cultural practices.
FAU - Jensen, Kipton
AU  - Jensen K
AD  - a Morehouse College , Department of Philosophy and Religion , 830 Westview Drive 
      SW , Atlanta , Georgia , 30314 , United States.
FAU - Gaie, Joseph Br
AU  - Gaie JB
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - Afr J AIDS Res
JT  - African journal of AIDS research : AJAR
JID - 101146510
OTO - NOTNLM
OT  - African philosophy
OT  - HIV testing
OT  - ethics
OT  - ethno-philosophy
OT  - policy development
OT  - socio-ethical systems
OT  - sub-Saharan Africa
EDAT- 2010/09/01 00:00
MHDA- 2010/09/01 00:01
CRDT- 2015/04/11 06:00
PHST- 2015/04/11 06:00 [entrez]
PHST- 2010/09/01 00:00 [pubmed]
PHST- 2010/09/01 00:01 [medline]
AID - 10.2989/16085906.2010.530187 [doi]
PST - ppublish
SO  - Afr J AIDS Res. 2010 Sep;9(3):297-305. doi: 10.2989/16085906.2010.530187.


PMID- 25860631
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150413
LR  - 20150411
IS  - 1608-5906 (Print)
IS  - 1608-5906 (Linking)
VI  - 9
IP  - 3
DP  - 2010 Sep
TI  - Nutrition education and counselling as strategic interventions to improvehealth
      outcomes in adult outpatients with HIV: a literature review.
PG  - 271-83
LID - 10.2989/16085906.2010.530183 [doi]
AB  - Malnutrition poses a significant risk for people living with HIV and accelerates 
      disease progression. This is because adequate nutrition is essential for optimal 
      immune function. This article discusses research on the role and use of nutrition
      education or counselling as a strategic intervention to improve health outcomes
      through better health behaviour in adult outpatients with HIV. Ten studies (five 
      quantitative and five qualitative) met the inclusion criteria of the literature
      review. The findings of the studies related to the following outcomes of
      nutrition interventions: increases in fat-free and lean body mass; offsetting the
      adverse effects of HIV infection in patients with a low CD4 cell count;
      significant improvement in dietary patterns with resultant greater adherence to
      HIV medications and fewer side effects; and agreement on the importance of
      addressing the nutrition concerns. The article discusses the five prominent
      themes that emerged from the literature review: 1) ethical issues in HIV/AIDS
      research; 2) the role of health and culture in nutrition interventions; 3) HIV
      stigma and its impact on nutrition interventions; 4) the socioeconomics of HIV
      and AIDS; and 5) food security and emotional wellbeing among persons with HIV.
      Although the evidence base is limited and raises questions about key aspects of
      the quality of the research conducted to date, the overall results show that
      providing HIV-positive adults with culturally relevant and practical nutrition
      strategies can improve health outcomes, health behaviour and quality of life.
      Current and future nutrition interventions for persons with HIV disease should be
      targeted, sustainable, and rigorously evaluated. There is an urgent need for
      research on this topic in developing countries, particularly African ones, which 
      are some of the most affected by HIV.
FAU - Kaye, Hannah L
AU  - Kaye HL
AD  - a 108 Third Avenue, Kenilworth 7708 , Cape Town , South Africa.
FAU - Moreno-Leguizamon, Carlos J
AU  - Moreno-Leguizamon CJ
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - Afr J AIDS Res
JT  - African journal of AIDS research : AJAR
JID - 101146510
OTO - NOTNLM
OT  - clinical practice
OT  - health education
OT  - health needs
OT  - health research
OT  - malnutrition
OT  - medical anthropology
OT  - nutrient supplementation
OT  - qualitative research
OT  - quantitative research
OT  - research methodology
OT  - social determinants of health
EDAT- 2010/09/01 00:00
MHDA- 2010/09/01 00:01
CRDT- 2015/04/11 06:00
PHST- 2015/04/11 06:00 [entrez]
PHST- 2010/09/01 00:00 [pubmed]
PHST- 2010/09/01 00:01 [medline]
AID - 10.2989/16085906.2010.530183 [doi]
PST - ppublish
SO  - Afr J AIDS Res. 2010 Sep;9(3):271-83. doi: 10.2989/16085906.2010.530183.


PMID- 25860629
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150413
LR  - 20150411
IS  - 1608-5906 (Print)
IS  - 1608-5906 (Linking)
VI  - 9
IP  - 3
DP  - 2010 Sep
TI  - The role of law in the regulation of HIV-vaccine research in South Africa and
      Kenya.
PG  - 249-59
LID - 10.2989/16085906.2010.530178 [doi]
AB  - Law is an important regulatory mechanism, particularly for creating an enabling
      research environment. However, the manner in which law addresses issues related
      to medical research, and HIV-vaccine research in particular, is at times
      inadequate and of great concern to the stakeholders involved in such research.
      The challenges for law as a regulatory mechanism in this regard are twofold: the 
      complexity of issues related to HIV-vaccine research, and the apparent
      disconnection between the legal and ethical frameworks that are applied in the
      regulation of these issues. This article analyses the extent to which these
      challenges have been addressed in South Africa and Kenya. Especially, it
      highlights the lessons that can be drawn from the two countries in establishing a
      suitable ethical-legal framework for HIV-vaccine research.
FAU - Andanda, Pamela
AU  - Andanda P
AD  - a University of the Witwatersrand , School of Law , Private Bag 3 , Johannesburg 
      , 2050 , South Africa.
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - Afr J AIDS Res
JT  - African journal of AIDS research : AJAR
JID - 101146510
OTO - NOTNLM
OT  - HIV/AIDS
OT  - drug research
OT  - ethics
OT  - guidelines
OT  - legal aspects
OT  - legislation
EDAT- 2010/09/01 00:00
MHDA- 2010/09/01 00:01
CRDT- 2015/04/11 06:00
PHST- 2015/04/11 06:00 [entrez]
PHST- 2010/09/01 00:00 [pubmed]
PHST- 2010/09/01 00:01 [medline]
AID - 10.2989/16085906.2010.530178 [doi]
PST - ppublish
SO  - Afr J AIDS Res. 2010 Sep;9(3):249-59. doi: 10.2989/16085906.2010.530178.


PMID- 24947301
OWN - NLM
STAT- MEDLINE
DCOM- 20170216
LR  - 20191112
IS  - 1910-622X (Print)
IS  - 1910-622X (Linking)
VI  - 23
IP  - 3
DP  - 2010 Sep
TI  - Conscientious objection: a call to nursing leadership.
PG  - 46-55
AB  - In this paper we argue that nurse leaders need to work actively to create morally
      supportive environments for nurses in Canada that provide adequate room to
      exercise conscientious objection. Morally supportive environments engender a safe
      atmosphere to engage in open dialogue and action regarding conflict of
      conscience. The CNA's 2008 Code of Ethics for Registered Nurses has recognized
      the importance of conscientious objection in nursing and has created key
      guidelines for the registered nurse to follow when a conflict in conscience is
      being considered or declared. Nurse leaders need to further develop the
      understanding of conflicts of conscience through education, well-written
      guidelines for conscientious objection in workplaces and engagement in research
      to uncover underlying barriers to the enactment of conscientious objections. With
      advancements in technology, changing healthcare policies and increasing scope of 
      practice, both reflection and dialogue on conscientious objection are critical
      for the continuing moral development of nurses in Canada.
FAU - Ford, Natalie J
AU  - Ford NJ
AD  - RN, BScN, Graduate Student, University of Alberta, Edmonton, AB.
FAU - Fraser, Kimberly D
AU  - Fraser KD
AD  - RN, PhD, Assistant Professor, Faculty of Nursing, University of Alberta,
      Edmonton, AB.
FAU - Marck, Patricia B
AU  - Marck PB
AD  - RN, PhD, Associate Professor, Faculty of Nursing, University of Alberta,
      Edmonton, AB.
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Nurs Leadersh (Tor Ont)
JT  - Nursing leadership (Toronto, Ont.)
JID - 101470760
MH  - *Attitude of Health Personnel
MH  - *Conscience
MH  - *Ethics, Nursing
MH  - Guideline Adherence
MH  - Humans
MH  - *Leadership
MH  - *Moral Development
MH  - *Negotiating
MH  - *Nurse's Role
MH  - Ontario
MH  - *Social Environment
EDAT- 2010/09/01 00:00
MHDA- 2017/02/17 06:00
CRDT- 2014/06/21 06:00
PHST- 2014/06/21 06:00 [entrez]
PHST- 2010/09/01 00:00 [pubmed]
PHST- 2017/02/17 06:00 [medline]
AID - 10.12927/cjnl.2010.21941 [doi]
PST - ppublish
SO  - Nurs Leadersh (Tor Ont). 2010 Sep;23(3):46-55. doi: 10.12927/cjnl.2010.21941.


PMID- 24431481
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 0273-1177 (Print)
IS  - 0273-1177 (Linking)
VI  - 46
IP  - 6
DP  - 2010 Sep 1
TI  - RADIOSENSITIVITY TO HIGH ENERGY IRON IONS IS INFLUENCED BY HETEROZYGOSITY for
      ATM, RAD9 and BRCA1.
PG  - 681-686
AB  - Loss of function of DNA repair genes has been implicated in the development of
      many types of cancer. In the last several years, heterozygosity leading to
      haploinsufficiency for proteins involved in DNA repair was shown to play a role
      in genomic instability and carcinogenesis after DNA damage is induced, for
      example by ionizing radiation. Since the effect of heterozygosity for one gene is
      relatively small, we hypothesize that predisposition to cancer could be a result 
      of the additive effect of heterozygosity for two or more genes critical to
      pathways that control DNA damage signaling, repair or apoptosis. We investigated 
      the role of heterozygosity for Atm, Rad9 and Brca1 on cell oncogenic
      transformation and cell survival induced by 1GeV/n (56)Fe ions. Our results show 
      that cells heterozygous for both Atm and Rad9 or Atm and Brca1 have high survival
      rates and are more sensitive to transformation by high energy Iron ions when
      compared with wild-type controls or cells haploinsufficient for only one of these
      proteins. Since mutations or polymorphisms for similar genes exist in a small
      percentage of the human population, we have identified a radiosensitive
      sub-population. This finding has several implications. First, the existence of a 
      radiosensitive sub-population may distort the shape of the dose-response
      relationship. Second, it would not be ethical to put exceptionally radiosensitive
      individuals into a setting where they may potentially be exposed to substantial
      doses of radiation.
FAU - Zhou, G
AU  - Zhou G
AD  - Center for Radiological Research, Columbia University Medical Center, New York,
      NY10032, USA.
FAU - Smilenov, L B
AU  - Smilenov LB
AD  - Center for Radiological Research, Columbia University Medical Center, New York,
      NY10032, USA.
FAU - Lieberman, H B
AU  - Lieberman HB
AD  - Center for Radiological Research, Columbia University Medical Center, New York,
      NY10032, USA.
FAU - Ludwig, T
AU  - Ludwig T
AD  - Institute for Cancer Genetics, Columbia University Medical Center, New York, NY
      10032, USA.
FAU - Hall, E J
AU  - Hall EJ
AD  - Center for Radiological Research, Columbia University Medical Center, New York,
      NY10032, USA.
LA  - eng
GR  - R01 GM079107/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PL  - England
TA  - Adv Space Res
JT  - Advances in space research : the official journal of the Committee on Space
      Research (COSPAR)
JID - 9878935
PMC - PMC3890108
MID - NIHMS537275
EDAT- 2010/09/01 00:00
MHDA- 2010/09/01 00:01
CRDT- 2014/01/17 06:00
PHST- 2014/01/17 06:00 [entrez]
PHST- 2010/09/01 00:00 [pubmed]
PHST- 2010/09/01 00:01 [medline]
AID - 10.1016/j.asr.2010.02.026 [doi]
PST - ppublish
SO  - Adv Space Res. 2010 Sep 1;46(6):681-686. doi: 10.1016/j.asr.2010.02.026.


PMID- 24409002
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 0038-6073 (Print)
IS  - 0038-6073 (Linking)
VI  - 61
IP  - 3-4
DP  - 2010 Sep 1
TI  - The Cosmopolitanization of Science: Experience from Chinese Stem Cell Scientists.
PG  - 255-274
AB  - It is commonly perceived that the 'globalization of science' may result in a
      'Westernization of science'. In this paper, however, I use the case of stem cell 
      science in China to demonstrate that developing countries are sometimes able to
      effectively shape the norms of global/local scientific exchange. Based on
      interviews with 38 stem cell scientists in six Chinese cities in early 2008, this
      paper elucidates Chinese scientists' outlook towards cross-border collaborations 
      and the effects that the internationalization of science has had on everyday
      laboratory operations. Findings suggest that although there still exists an
      asymmetry of scientific influence, and in many aspects China is still
      'catching-up' to the West, there is also a changing nature of communication
      beyond borders. One key aspect of recent international scientific development is 
      the growing necessity for local stakeholders to acquire a global mindset and to
      compare, reflect and accommodate diverse interests. This is what I define as the 
      'cosmopolitanization of science'. The study empirically examines the sociological
      and methodological implications of the cosmopolitanization process and further
      develops Ulrich Beck's cosmopolitan theory by delineating four main features of
      the 'cosmopolitanization of science': shared future benefits, passive
      ethicization, reflexive negotiation, and continuous performance.
FAU - Zhang, Joy Yueyue
AU  - Zhang JY
LA  - eng
GR  - Wellcome Trust/United Kingdom
GR  - 080526/Wellcome Trust/United Kingdom
PT  - Journal Article
PL  - Germany
TA  - Soz Welt
JT  - Soziale Welt : Zeitschrift fuer sozialwissenschaftliche Forschung und Praxis
JID - 101617394
PMC - PMC3882428
MID - EMS54004
EDAT- 2010/09/01 00:00
MHDA- 2010/09/01 00:01
CRDT- 2014/01/11 06:00
PHST- 2014/01/11 06:00 [entrez]
PHST- 2010/09/01 00:00 [pubmed]
PHST- 2010/09/01 00:01 [medline]
PST - ppublish
SO  - Soz Welt. 2010 Sep 1;61(3-4):255-274.


PMID- 23447766
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130708
LR  - 20211021
IS  - 1524-6205 (Print)
IS  - 1524-6205 (Linking)
VI  - 2010
DP  - 2010 Sep
TI  - Long-term Memories: The Good, the Bad, and the Ugly.
PG  - 21
AB  - Traumatic memories haunt the lives of people suffering from post-traumatic stress
      disorder, or PTSD, and other illnesses. Fortunately, recent research into the
      changeability of long-term memories may someday develop into treatments for such 
      individuals. But before this can happen, writes Cristina Alberini, Ph.D., of
      Mount Sinai School of Medicine, researchers must determine just how effectively
      the fear associated with older memories-especially those involved in PTSD-can be 
      reduced and for how long. Researchers must also address the ethical issues that
      go hand in hand with modifying memory.
FAU - Alberini, Cristina M
AU  - Alberini CM
LA  - eng
GR  - R01 MH065635/MH/NIMH NIH HHS/United States
GR  - R01 MH074736/MH/NIMH NIH HHS/United States
GR  - R21 DA017672/DA/NIDA NIH HHS/United States
GR  - R37 MH065635/MH/NIMH NIH HHS/United States
PT  - Journal Article
DEP - 20101029
PL  - United States
TA  - Cerebrum
JT  - Cerebrum : the Dana forum on brain science
JID - 100888555
PMC - PMC3574792
EDAT- 2010/09/01 00:00
MHDA- 2010/09/01 00:01
CRDT- 2013/03/01 06:00
PHST- 2013/03/01 06:00 [entrez]
PHST- 2010/09/01 00:00 [pubmed]
PHST- 2010/09/01 00:01 [medline]
PST - ppublish
SO  - Cerebrum. 2010 Sep;2010:21. Epub 2010 Oct 29.


PMID- 22145562
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20181201
IS  - 0723-1393 (Print)
IS  - 0723-1393 (Linking)
VI  - 29
IP  - 3
DP  - 2010 Sep
TI  - Legal values as tools for promoting harmony.
PG  - 433-42
AB  - The doctrine of informed consent has the effect of allowing the mentally
      competent adult patient to exercise individual choice in any proposed medical
      treatment. The ethical principles primarily inherent in this doctrine would be
      the principles of autonomy and beneficence. However, it is argued in this essay
      that the concept and meaning of autonomy might be vastly different between
      western and eastern communities. Consequently the doctrine of informed consent
      will lead to a different meaning in these different societies. The essay also
      raises the implication of transplanting legal doctrines into societies which
      might not be fully prepared to implement the ideal contained in the doctrine of
      informed consent.
FAU - Talib, Norchaya
AU  - Talib N
AD  - Faculty of Law, University of Malaya.
LA  - eng
PT  - Journal Article
PT  - Legal Case
PL  - United States
TA  - Med Law
JT  - Medicine and law
JID - 8218185
SB  - IM
MH  - *Ethics, Medical
MH  - Humans
MH  - Informed Consent/*legislation & jurisprudence
MH  - *Personal Autonomy
EDAT- 2010/09/01 00:00
MHDA- 2012/01/27 06:00
CRDT- 2011/12/08 06:00
PHST- 2011/12/08 06:00 [entrez]
PHST- 2010/09/01 00:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
PST - ppublish
SO  - Med Law. 2010 Sep;29(3):433-42.


PMID- 22145561
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20170203
IS  - 0723-1393 (Print)
IS  - 0723-1393 (Linking)
VI  - 29
IP  - 3
DP  - 2010 Sep
TI  - Predictive genetic tests for employment purposes: why not?
PG  - 419-32
AB  - Given the uncertainty that characterizes genetic information in relation to the
      pressing ethical and deontological questions involved in their acquisition and
      subsequent use, and in the context of enormous social relevance, it is essential 
      to have international legislation authorizing the use of such tests for genetic
      monitoring of employed persons compatible with the need to protect their privacy.
FAU - Cannovo, Nunzia
AU  - Cannovo N
AD  - Department of Public Medicine and Social Security, Legal Medicine Section,
      University of Naples Federico II.
FAU - Paternoster, Mariano
AU  - Paternoster M
FAU - Buccelli, Claudio
AU  - Buccelli C
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Law
JT  - Medicine and law
JID - 8218185
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Employment/*legislation & jurisprudence
MH  - Genetic Markers
MH  - Genetic Privacy/*legislation & jurisprudence
MH  - Genetic Testing/*legislation & jurisprudence
MH  - Humans
EDAT- 2010/09/01 00:00
MHDA- 2012/01/27 06:00
CRDT- 2011/12/08 06:00
PHST- 2011/12/08 06:00 [entrez]
PHST- 2010/09/01 00:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
PST - ppublish
SO  - Med Law. 2010 Sep;29(3):419-32.


PMID- 22145560
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20170203
IS  - 0723-1393 (Print)
IS  - 0723-1393 (Linking)
VI  - 29
IP  - 3
DP  - 2010 Sep
TI  - Bioethics committees and examining consent within the patient-physician
      relationship in Turkey.
PG  - 403-18
AB  - Clinical exercises include questions about a physician's behaviour, decision
      making process, values, rights and responsibilities, as much as the
      scientific-technical questions concerning the disease. Some of these questions
      may be easily answered, for there are well-constructed activity options that have
      found widespread acceptance regarding what has to be done. However, it is quite
      difficult to answer the questions with problematic options, or the ones on which 
      a compromised attitude is not present. Patient participation in treatment-related
      decision-making has been promoted as being ethically and clinically desirable in 
      Western countries. Several studies have indicated that patient participation in
      decision-making has a positive influence on their health outcomes, thereby
      increasing patient satisfaction regarding medical care and promoting patient
      autonomy. Over the last decade, patient involvement in treatment-related
      decision-making has been widely advocated in Turkey, where patient-physician
      encounters are still under the influence of the long-standing tradition of
      paternalism. Despite this profound change in clinical practice, studies
      investigating the actual preferences of Turkish people regarding involvement in
      treatment-related decision-making are limited. In Turkey, to protect the rights
      of patients, current Govermental requirements mandate that all human biomedical
      research and medical intervention be accompanied by a consent form that contains 
      the information necessary for an informed decision. In addition, they require
      that the information provided to the subject or the representative shall be
      explained in appropriate language. Especially after the new regulations in the
      Turkish Penal Code, physicians and nurses have started to be more sensitive
      towards informed consent and have become more conscious about their
      responsibilities. It has started to be questioned more, and as a result, the
      problems experienced about patient consent in medical applications created new
      ethical dilemmas. Informed consent is acknowledged to be the most essential
      constituent of patient rights today. In this paper, after introducing a general
      overview of the significance and requirements of informed consent, we will
      consecutively discuss the decision making and informed consent process, legal
      arrangements concerning this issue in Turkey, the approaches of physicians and
      patients towards the topic, and regarding informed consent, we will discuss the
      responsibilities of hospital ethics committees.
FAU - Buken, Nuket Ornek
AU  - Buken NO
AD  - Hacettepe University Faculty of Medicine, Department of Deontology & Medical
      Ethics, Ankara, Turkey.
FAU - Arapkirlioglu, Kumru
AU  - Arapkirlioglu K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Law
JT  - Medicine and law
JID - 8218185
SB  - IM
MH  - *Ethics Committees, Clinical
MH  - Humans
MH  - Informed Consent/*legislation & jurisprudence
MH  - Patient Participation
MH  - Patient Rights/*legislation & jurisprudence
MH  - Personal Autonomy
MH  - *Physician-Patient Relations
MH  - Turkey
EDAT- 2010/09/01 00:00
MHDA- 2012/01/27 06:00
CRDT- 2011/12/08 06:00
PHST- 2011/12/08 06:00 [entrez]
PHST- 2010/09/01 00:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
PST - ppublish
SO  - Med Law. 2010 Sep;29(3):403-18.


PMID- 22145558
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20170203
IS  - 0723-1393 (Print)
IS  - 0723-1393 (Linking)
VI  - 29
IP  - 3
DP  - 2010 Sep
TI  - Can unethically produced data be used ethically?
PG  - 373-87
AB  - BACKGROUND: Breaches of medical ethics such as the failure to obtain consent and 
      the failure to allow exit from an experiment, are but two violations that
      undermine scientific and medical research. This paper provides the results of a
      survey that asked medical researchers and scientists their views on the use of
      data from unethical medical experiments. METHODS: Questionnaires were sent to
      sixty-eight physicians, bioethicists, psychiatrists and scientists. Four cases of
      unethical experiments were presented and questions related to the use of the data
      from those experiments were posed to the participants. RESULTS: Responses were
      obtained from 47% (32) of those approached. CONCLUSIONS: The majority of
      respondents replied that they would use the data if it would save a life or
      improve the quality of life of an individual or members of society as a whole.
FAU - Halpin, Ross W
AU  - Halpin RW
AD  - University of Sydney, Australia.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Law
JT  - Medicine and law
JID - 8218185
SB  - IM
MH  - Biomedical Research
MH  - *Ethics, Research
MH  - Female
MH  - Helsinki Declaration
MH  - Humans
MH  - Male
MH  - *Scientific Misconduct
MH  - Surveys and Questionnaires
EDAT- 2010/09/01 00:00
MHDA- 2012/01/27 06:00
CRDT- 2011/12/08 06:00
PHST- 2011/12/08 06:00 [entrez]
PHST- 2010/09/01 00:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
PST - ppublish
SO  - Med Law. 2010 Sep;29(3):373-87.


PMID- 22145557
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20191210
IS  - 0723-1393 (Print)
IS  - 0723-1393 (Linking)
VI  - 29
IP  - 3
DP  - 2010 Sep
TI  - Illicit drugs, testing, prevention and work in France: ethical and legal issues.
PG  - 353-72
AB  - The use of illicit drugs in the workplace raises issues pertaining to prevention 
      and safety and the responsibility of the various members of staff. It also brings
      into question the interface between work and private life. If employees are in
      theory responsible for their own safety and risk heavy penalties in the event of 
      the consumption of illicit drugs in the workplace, such behaviour has to be
      proved. In reality, the worker can only be partially and marginally held liable, 
      given the fact that the employer is prohibited from infringing on their rights
      and liberties (restrictions on the searching of their personal belongings and
      lockers as well as on the carrying out of breath testing and saliva testing under
      restrictive conditions). Employers have for their part a broader range of
      responsibilities and, above all, an absolute obligation to achieve specific goals
      in terms of health and safety resulting in the need to take action. In accordance
      with the International Labour Organization recommendations, European and national
      legislation, the employer has to implement a suitable preventive policy. However,
      where is the balance between prevention and repression? Very few studies have
      raised these issues and our aim is to precisely situate the place of drug testing
      in the employer's repressive arsenal in France and to try to answer the legal and
      ethical issues raised. Thus, for example, repression can only be acceptable when 
      it deals with moderate and non-addicted users, or it could be tantamount to
      discrimination.
FAU - Fantoni-Quinton, Sophie
AU  - Fantoni-Quinton S
AD  - Department of Occupational medicine, Chru Lille, Gip Cereste, University of
      Lille, Northern France.
FAU - Bossu, Bernard
AU  - Bossu B
FAU - Morgenroth, Thomas
AU  - Morgenroth T
FAU - Frimat, Paul
AU  - Frimat P
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Law
JT  - Medicine and law
JID - 8218185
RN  - 0 (Illicit Drugs)
SB  - IM
MH  - France
MH  - Humans
MH  - *Illicit Drugs
MH  - Liability, Legal
MH  - Mandatory Testing/*ethics/*legislation & jurisprudence
MH  - Occupational Medicine/ethics/legislation & jurisprudence
MH  - Substance Abuse Detection/*legislation & jurisprudence
MH  - Substance-Related Disorders/diagnosis/prevention & control
EDAT- 2010/09/01 00:00
MHDA- 2012/01/27 06:00
CRDT- 2011/12/08 06:00
PHST- 2011/12/08 06:00 [entrez]
PHST- 2010/09/01 00:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
PST - ppublish
SO  - Med Law. 2010 Sep;29(3):353-72.


PMID- 22145556
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20170203
IS  - 0723-1393 (Print)
IS  - 0723-1393 (Linking)
VI  - 29
IP  - 3
DP  - 2010 Sep
TI  - Provision 280 of the Turkish Penal Code: infringes on physician's dignity.
PG  - 341-51
AB  - Every medical interference could be interpreted as an intervention into one's
      physical integrity and physical autonomy. This fact has brought along the
      necessity of determining the responsibilities of physicians, apotheosized
      throughout history from time to time, and to define the limits of the medical
      profession. The Turkish Penal Code (TPC) is the kind of legislation that imposes 
      such limits. A revised version of the TPC has been in effect since June 1st,
      2005. Ever since its enforcement, the TPC has attracted fierce criticism from
      several counts. However, Provision 280 is considered to be the most problematic
      one with regard to medical ethics. Along with several critical aspects, this
      provision stipulates almost a psychological violence for all health care
      professionals, particularly for the physicians as a matter of intervening with
      human dignity. The above-mentioned provision 280 needs to be annulled promptly in
      order to prevent physicians from remaining under psychological pressure while
      practicing their professions, as well as maintaining the moral values of the
      profession.
FAU - Izgi, M Cumhur
AU  - Izgi MC
AD  - Goynuk Saglik Ocugi.
FAU - Oguz, N Yasemin
AU  - Oguz NY
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Law
JT  - Medicine and law
JID - 8218185
SB  - IM
MH  - *Ethics, Medical
MH  - Humans
MH  - *Personhood
MH  - *Physician-Patient Relations
MH  - Physicians/*legislation & jurisprudence
MH  - Turkey
EDAT- 2010/09/01 00:00
MHDA- 2012/01/27 06:00
CRDT- 2011/12/08 06:00
PHST- 2011/12/08 06:00 [entrez]
PHST- 2010/09/01 00:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
PST - ppublish
SO  - Med Law. 2010 Sep;29(3):341-51.


PMID- 22145555
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20170203
IS  - 0723-1393 (Print)
IS  - 0723-1393 (Linking)
VI  - 29
IP  - 3
DP  - 2010 Sep
TI  - Rethinking the meaning of being a scientist--the role of scientific integrity
      boards and some thoughts about scientific culture.
PG  - 329-39
AB  - Biomedicine is a fast moving and often challenging research field. To this
      extent, it seems that preserving one's integrity is becoming more and more
      complex and occasionally stressful for individual researchers. Highly competitive
      funding and publication, the commercialization of biomedicine in general, the
      media hype about some scientific fields, the politicization of research and
      higher education, and, last but not least, the increasing specialization
      necessary to deal with increasingly sophisticated experimental systems and
      technologies are aspects of this complexity. While guidelines and overseeing
      control boards are important regulatory instruments, which also serve to enhance 
      awareness of scientific integrity and to increase transparency, are not
      sufficient to maintain and further develop a positive academic climate that
      motivates the community to adhere to high and consistent professional ethics.
      Here, scientific misconduct and misbehaviour will be illustrated by referring to 
      well-documented cases and to the need for improving scientific culture, which
      will be discussed in depth.
FAU - Werner-Felmayer, Gabriele
AU  - Werner-Felmayer G
AD  - Division of Biological Chemistry, Biocentre, Medical University of Innsbruck,
      Innsbruck, Austria.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Law
JT  - Medicine and law
JID - 8218185
SB  - IM
MH  - *Culture
MH  - Ethics Committees, Research
MH  - Humans
MH  - *Science
MH  - *Scientific Misconduct
EDAT- 2010/09/01 00:00
MHDA- 2012/01/27 06:00
CRDT- 2011/12/08 06:00
PHST- 2011/12/08 06:00 [entrez]
PHST- 2010/09/01 00:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
PST - ppublish
SO  - Med Law. 2010 Sep;29(3):329-39.


PMID- 20803633
OWN - NLM
STAT- MEDLINE
DCOM- 20101210
LR  - 20100830
IS  - 1557-0681 (Electronic)
IS  - 1478-2189 (Linking)
VI  - 8
IP  - 3
DP  - 2010 Sep
TI  - Do hypermobile subjects without pain have alteration to the feedback mechanisms
      controlling the shoulder girdle?
PG  - 157-63
LID - 10.1002/msc.178 [doi]
AB  - OBJECTIVES: It has been reported that hypermobile subjects have proprioceptive
      deficits. However, it remains unclear whether pain-free subjects with
      hypermobility also have deficits. METHODS: Ten subjects with hypermobility and
      nine without hypermobility were recruited following ethical approval and informed
      consent. Shoulder mobility, joint position sense (JPS) and a reflex of trapezius 
      evoked from arm afferents were compared. RESULTS: There was greater shoulder
      mobility in the hypermobile group (p = 0.004). There were no differences in
      shoulder JPS between the groups (p = 0.27), although, the hypermobile group
      displayed a larger degree of variability (p = 0.014). Finally, there were no
      differences in the latency of upper and lower trapezius reflexes evoked from arm 
      afferents (p = 0.86 and 0.98, respectively). CONCLUSIONS: In a group of people
      with hypermobility without shoulder problems, there was no difference in either
      shoulder JPS or reflex latency when compared with a non- hypermobile group. The
      relevance of pain to proprioceptive deficits is discussed.
CI  - 2010 John Wiley & Sons, Ltd.
FAU - Jeremiah, H M
AU  - Jeremiah HM
AD  - Royal National Orthopaedic Hospital NHS Trust, Brockley Hill, Stanmore,
      Middlesex, HA7 4LP, UK. helenmjeremiah@yahoo.co.uk
FAU - Alexander, C M
AU  - Alexander CM
LA  - eng
PT  - Journal Article
PL  - England
TA  - Musculoskeletal Care
JT  - Musculoskeletal care
JID - 101181344
SB  - IM
MH  - Adult
MH  - Ehlers-Danlos Syndrome/complications/*physiopathology
MH  - Feedback, Physiological/*physiology
MH  - Female
MH  - Humans
MH  - Joint Instability/etiology/*physiopathology
MH  - Male
MH  - Muscle, Skeletal
MH  - Pain/etiology/*physiopathology
MH  - *Proprioception
MH  - Range of Motion, Articular
MH  - Shoulder Joint/*physiopathology
EDAT- 2010/08/31 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/31 06:00
PHST- 2010/08/31 06:00 [entrez]
PHST- 2010/08/31 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1002/msc.178 [doi]
PST - ppublish
SO  - Musculoskeletal Care. 2010 Sep;8(3):157-63. doi: 10.1002/msc.178.


PMID- 20803259
OWN - NLM
STAT- MEDLINE
DCOM- 20120330
LR  - 20220310
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 17
IP  - 3
DP  - 2011 Sep
TI  - Scientific research and the public trust.
PG  - 399-409
LID - 10.1007/s11948-010-9210-x [doi]
AB  - This essay analyzes the concept of public trust in science and offers some
      guidance for ethicists, scientists, and policymakers who use this idea defend
      ethical rules or policies pertaining to the conduct of research. While the notion
      that public trusts science makes sense in the abstract, it may not be
      sufficiently focused to support the various rules and policies that authors have 
      tried to derive from it, because the public is not a uniform body with a common
      set of interests. Well-focused arguments that use public trust to support rules
      or policies for the conduct of research should specify (a) which public is being 
      referred to (e.g. the general public or a specific public, such as a particular
      community or group); (b) what this public expects from scientists; (c) how the
      rule or policy will ensure that these expectations are met; and (d) why is it
      important to meet these expectations.
FAU - Resnik, David B
AU  - Resnik DB
AD  - National Institute of Environmental Health Sciences, National Institutes of
      Health, Box 12233, Mail Drop CU 03, Research Triangle Park, NC 27709, USA.
      resnikd@niehs.nih.gov
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
DEP - 20100829
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Animals
MH  - Biomedical Research/ethics
MH  - *Ethics, Research
MH  - Humans
MH  - *Public Opinion
MH  - Science/*ethics
MH  - *Trust
PMC - PMC3151305
MID - NIHMS286366
EDAT- 2010/08/31 06:00
MHDA- 2012/03/31 06:00
CRDT- 2010/08/31 06:00
PHST- 2010/04/07 00:00 [received]
PHST- 2010/05/17 00:00 [accepted]
PHST- 2010/08/31 06:00 [entrez]
PHST- 2010/08/31 06:00 [pubmed]
PHST- 2012/03/31 06:00 [medline]
AID - 10.1007/s11948-010-9210-x [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2011 Sep;17(3):399-409. doi: 10.1007/s11948-010-9210-x. Epub 2010
      Aug 29.


PMID- 20802002
OWN - NLM
STAT- MEDLINE
DCOM- 20100923
LR  - 20220309
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 341
DP  - 2010 Aug 27
TI  - Streamlined research governance: are we there yet?
PG  - c4625
LID - 10.1136/bmj.c4625 [doi]
LID - bmj.c4625 [pii]
AB  - Despite the promise of a new streamlined process for gaining research ethics and 
      governance approval, Nina Fudge, Judith Redfern, Charles Wolfe, and Christopher
      McKevitt argue that the process is still dogged by delay and arbitrary decisions.
FAU - Fudge, Nina
AU  - Fudge N
AD  - King's College London, Department of Primary Care and Public Health Sciences, 7th
      Floor Capital House, 42 Weston Street, London SE1 3QD. nina.fudge@kcl.ac.uk
FAU - Redfern, Judith
AU  - Redfern J
FAU - Wolfe, Charles
AU  - Wolfe C
FAU - McKevitt, Christopher
AU  - McKevitt C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100827
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
SB  - IM
MH  - Biomedical Research/legislation & jurisprudence/*organization & administration
MH  - Health Policy
MH  - United Kingdom
EDAT- 2010/08/31 06:00
MHDA- 2010/09/24 06:00
CRDT- 2010/08/31 06:00
PHST- 2010/08/31 06:00 [entrez]
PHST- 2010/08/31 06:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
AID - 10.1136/bmj.c4625 [doi]
PST - epublish
SO  - BMJ. 2010 Aug 27;341:c4625. doi: 10.1136/bmj.c4625.


PMID- 20801967
OWN - NLM
STAT- MEDLINE
DCOM- 20110211
LR  - 20100830
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 5
DP  - 2010 Sep
TI  - Ethical openings in palliative home care practice.
PG  - 655-65
LID - 10.1177/0969733010373425 [doi]
AB  - Understanding how a nurse acts in a particular situation reveals how nurses enact
      their ethics in day-to-day nursing. Our ethical frameworks assist us when we
      experience serious ethical dilemmas. Yet how a nurse responds in situations of
      daily practice is contingent upon all the presenting cues that build the current 
      moment. In this article, we look at how a home care nurse responds to the ethical
      opening that arises when the nurse enters a person's home. We discuss how the
      home presents the nurse with knowledge that informs the provision of ethical
      nursing care. The analysis is based on findings from an interpretive research
      study in palliative home care in Canada. Through interpretive analysis of a
      nursing situation we delineate how the nurse engages with the whole and acts
      inside the moment. The analysis shows how home care nurses are ethically
      determined to engage with whatever is going on in a patient's home.
FAU - Santos Salas, Anna
AU  - Santos Salas A
AD  - Faculty of Nursing, University of Alberta, Edmonton, Alberta, Canada.
      avs@ualberta.ca
FAU - Cameron, Brenda L
AU  - Cameron BL
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Adaptation, Psychological
MH  - Alberta
MH  - *Attitude of Health Personnel
MH  - Attitude to Health
MH  - Clinical Competence
MH  - Ethical Analysis
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - Home Care Services/*ethics/organization & administration
MH  - Humans
MH  - Middle Aged
MH  - *Nurse's Role/psychology
MH  - *Nurse-Patient Relations/ethics
MH  - Nursing Methodology Research
MH  - Nursing Staff/ethics/organization & administration/psychology
MH  - Palliative Care/*ethics/organization & administration/psychology
MH  - Pancreatic Neoplasms/nursing/psychology
EDAT- 2010/08/31 06:00
MHDA- 2011/02/12 06:00
CRDT- 2010/08/31 06:00
PHST- 2010/08/31 06:00 [entrez]
PHST- 2010/08/31 06:00 [pubmed]
PHST- 2011/02/12 06:00 [medline]
AID - 17/5/655 [pii]
AID - 10.1177/0969733010373425 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 Sep;17(5):655-65. doi: 10.1177/0969733010373425.


PMID- 20801965
OWN - NLM
STAT- MEDLINE
DCOM- 20110211
LR  - 20191210
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 5
DP  - 2010 Sep
TI  - Battlefield conditions: different environment but the same duty of care.
PG  - 636-45
LID - 10.1177/0969733010373434 [doi]
AB  - Using an interpretative research approach to ethical and legal literature, it is 
      argued that nursing in the battlefield is distinctly different to civilian
      nursing, even in an emergency, and that the environment is so different that a
      duty of care owed by military nurses to wounded soldiers should not apply. Such
      distinct differences in wartime can override normal peacetime professional ethics
      to the extent that the duty of care owed by military nurses to their patients on 
      the battlefield should not exist. It is also argued that as military nurses have 
      legal and professional obligations to care for wounded soldiers on the
      battlefield, this obligation conflicts with following military orders, causing a 
      dual loyalty conflict. This is because soldiers are part of the 'fighting force' 
      and must be fit to fight and win the battle. This makes them more of a commodity 
      rather than individual persons with distinct health care needs.
FAU - Kelly, Janet
AU  - Kelly J
AD  - Department of Professional Health Studies, Faculty of Health and Social Care,
      University of Hull, Hull, UK. j.kelly@hull.ac.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Commodification
MH  - Conflict, Psychological
MH  - Employee Discipline/ethics/legislation & jurisprudence
MH  - Ethical Analysis
MH  - Health Facility Environment/ethics/organization & administration
MH  - Humans
MH  - Military Nursing/*ethics/organization & administration
MH  - Military Personnel
MH  - *Moral Obligations
MH  - *Nurse's Role
MH  - Nurse-Patient Relations/ethics
MH  - Patient Advocacy/*ethics/legislation & jurisprudence
MH  - United Kingdom
MH  - Warfare/*ethics
EDAT- 2010/08/31 06:00
MHDA- 2011/02/12 06:00
CRDT- 2010/08/31 06:00
PHST- 2010/08/31 06:00 [entrez]
PHST- 2010/08/31 06:00 [pubmed]
PHST- 2011/02/12 06:00 [medline]
AID - 17/5/636 [pii]
AID - 10.1177/0969733010373434 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 Sep;17(5):636-45. doi: 10.1177/0969733010373434.


PMID- 20801962
OWN - NLM
STAT- MEDLINE
DCOM- 20110211
LR  - 20220321
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 5
DP  - 2010 Sep
TI  - Mentoring overseas nurses: barriers to effective and non-discriminatory mentoring
      practices.
PG  - 603-13
LID - 10.1177/0969733010368747 [doi]
AB  - In this article it is argued that there are barriers to effective and
      non-discriminatory practice when mentoring overseas nurses within the National
      Health Service (NHS) and the care home sector. These include a lack of awareness 
      about how cultural differences affect mentoring and learning for overseas nurses 
      during their period of supervised practice prior to registration with the UK
      Nursing and Midwifery Council. These barriers may demonstrate a lack of effective
      teaching of ethical practice in the context of cultural diversity in health care.
      This argument is supported by empirical data from a national study. Interviews
      were undertaken with 93 overseas nurses and 24 national and 13 local managers and
      mentors from six research sites involving UK health care employers in the NHS and
      independent sectors in different regions of the UK. The data collected showed
      that overseas nurses are discriminated against in their learning by poor
      mentoring practices; equally, from these data, it appears that mentors are
      ill-equipped by existing mentor preparation programmes to mentor overseas-trained
      nurses from culturally diverse backgrounds. Recommendations are made for
      improving mentoring programmes to address mentors' ability to facilitate learning
      in a culturally diverse workplace and thereby improve overseas nurses'
      experiences of their supervised practice.
FAU - Allan, Helen
AU  - Allan H
AD  - University of Surrey, Centre for Research in Nursing and Midwifery Education,
      Faculty of Health and Medical Sciences, Guildford, UK. h.allan@surrey.ac.uk
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Adult
MH  - Attitude of Health Personnel/*ethnology
MH  - Bullying/ethics/psychology
MH  - Career Mobility
MH  - Cultural Competency/education/ethics/psychology
MH  - Education, Nursing, Continuing/ethics/organization & administration
MH  - Female
MH  - Foreign Professional Personnel/education/*psychology
MH  - Health Services Needs and Demand
MH  - Humans
MH  - *Interprofessional Relations/ethics
MH  - Male
MH  - *Mentors/education/psychology
MH  - Middle Aged
MH  - Nurse's Role/psychology
MH  - Nursing Methodology Research
MH  - Nursing Staff/education/ethics/*psychology
MH  - Personnel Selection
MH  - *Prejudice
MH  - Surveys and Questionnaires
MH  - United Kingdom
EDAT- 2010/08/31 06:00
MHDA- 2011/02/12 06:00
CRDT- 2010/08/31 06:00
PHST- 2010/08/31 06:00 [entrez]
PHST- 2010/08/31 06:00 [pubmed]
PHST- 2011/02/12 06:00 [medline]
AID - 17/5/603 [pii]
AID - 10.1177/0969733010368747 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 Sep;17(5):603-13. doi: 10.1177/0969733010368747.


PMID- 20801961
OWN - NLM
STAT- MEDLINE
DCOM- 20110211
LR  - 20191210
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 5
DP  - 2010 Sep
TI  - Ethical vulnerabilities in nursing history: conflicting loyalties and the patient
      as 'other'.
PG  - 590-602
LID - 10.1177/0969733010368746 [doi]
AB  - The purpose of this article is to explore enduring ethical vulnerabilities of the
      nursing profession as illustrated in historical chapters of nursing's past. It
      describes these events, then explores two ethical vulnerabilities in depth:
      conflicting loyalties and duties, and relationships with patients as 'other'. The
      article concludes with suggestions for more ethical approaches to the other in
      current nursing practice. The past may be one of the most fruitful sites for
      examining enduring ethical vulnerabilities of the nursing profession. First of
      all, professional identity, which includes moral identity, comes in part from
      knowledge of the nursing profession's past. Second, looking to the past to
      understand better how events and ideologies have brought vulnerabilities to the
      fore raises questions about ethical nursing practice today.
FAU - Lagerwey, Mary Deane
AU  - Lagerwey MD
AD  - Western Michigan University, Bronson School of Nursing, Kalamazoo, MI 49008, USA.
      mary.lagerwey@wmich.edu.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Conflict, Psychological
MH  - Ethics, Institutional/*history
MH  - Ethics, Nursing/*history
MH  - Family Planning Services/history
MH  - Germany
MH  - History, 20th Century
MH  - Humans
MH  - Indians, North American/history
MH  - National Socialism/history
MH  - New Mexico
MH  - Nurse's Role/*history
MH  - *Nurse-Patient Relations
MH  - Patient Advocacy/*history
MH  - Philosophy, Nursing/*history
MH  - Religious Missions/history
EDAT- 2010/08/31 06:00
MHDA- 2011/02/12 06:00
CRDT- 2010/08/31 06:00
PHST- 2010/08/31 06:00 [entrez]
PHST- 2010/08/31 06:00 [pubmed]
PHST- 2011/02/12 06:00 [medline]
AID - 17/5/590 [pii]
AID - 10.1177/0969733010368746 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 Sep;17(5):590-602. doi: 10.1177/0969733010368746.


PMID- 20801959
OWN - NLM
STAT- MEDLINE
DCOM- 20110211
LR  - 20191210
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 5
DP  - 2010 Sep
TI  - Dare we speak of ethics? Attending to the unsayable amongst nurse leaders.
PG  - 566-76
LID - 10.1177/0969733010373433 [doi]
AB  - There is increasing emphasis on the need for collaboration between practice and
      academic leaders in health care research. However, many problems can arise owing 
      to differences between academic and clinical goals and timelines. In order for
      research to move forward it is important to name and address these issues early
      in a project. In this article we use an example of a participatory action
      research study of ethical practice in nursing to highlight some of the issues
      that are not frequently discussed and we identify the impact of things not-named.
      Further, we offer our insights to others who wish to be partners in research
      between academic and practice settings. These findings have wide implications for
      ameliorating misunderstandings that may develop between nurse leaders in light of
      collaborative research, as well as for participatory action research.
FAU - Schick Makaroff, Kara
AU  - Schick Makaroff K
AD  - University of Victoria, School of Nursing, Victoria, BC, Canada. karimasm@uvic.ca
FAU - Storch, Janet
AU  - Storch J
FAU - Newton, Lorelei
AU  - Newton L
FAU - Fulton, Tom
AU  - Fulton T
FAU - Stevenson, Lynne
AU  - Stevenson L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Attitude of Health Personnel
MH  - British Columbia
MH  - Canada
MH  - Communication Barriers
MH  - Community-Based Participatory Research
MH  - Conflict, Psychological
MH  - *Cooperative Behavior
MH  - *Ethics, Nursing
MH  - *Faculty, Nursing
MH  - Health Facility Environment/ethics
MH  - Humans
MH  - Interprofessional Relations/ethics
MH  - *Leadership
MH  - *Nurse Administrators/ethics/psychology
MH  - Research Design
MH  - Semantics
MH  - Workplace/psychology
EDAT- 2010/08/31 06:00
MHDA- 2011/02/12 06:00
CRDT- 2010/08/31 06:00
PHST- 2010/08/31 06:00 [entrez]
PHST- 2010/08/31 06:00 [pubmed]
PHST- 2011/02/12 06:00 [medline]
AID - 17/5/566 [pii]
AID - 10.1177/0969733010373433 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 Sep;17(5):566-76. doi: 10.1177/0969733010373433.


PMID- 20801958
OWN - NLM
STAT- MEDLINE
DCOM- 20110211
LR  - 20100830
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 5
DP  - 2010 Sep
TI  - Courage and nursing practice: a theoretical analysis.
PG  - 551-65
LID - 10.1177/0969733010369475 [doi]
AB  - This article aims to deepen the understanding of courage through a theoretical
      analysis of classical philosophers' work and a review of published and
      unpublished empirical research on courage in nursing. The authors sought answers 
      to questions regarding how courage is understood from a philosophical viewpoint
      and how it is expressed in nursing actions. Four aspects were identified as
      relevant to a deeper understanding of courage in nursing practice: courage as an 
      ontological concept, a moral virtue, a property of an ethical act, and a creative
      capacity. The literature review shed light on the complexity of the concept of
      courage and revealed some lack of clarity in its use. Consequently, if courage is
      to be used consciously to influence nurses' ethical actions it seems important to
      recognize its specific features. The results suggest it is imperative to foster
      courage among nurses and student nurses to prepare them for ethical, creative
      action and further the development of professional nursing practices.
FAU - Lindh, Inga-Britt
AU  - Lindh IB
AD  - University of Stavanger, Norway. inga-britt.lindh@hkr.se
FAU - Barbosa da Silva, Antonio
AU  - Barbosa da Silva A
FAU - Berg, Agneta
AU  - Berg A
FAU - Severinsson, Elisabeth
AU  - Severinsson E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Character
MH  - Ethical Analysis
MH  - *Ethical Theory
MH  - *Ethics, Nursing
MH  - Existentialism/psychology
MH  - Humanism
MH  - Humans
MH  - Moral Obligations
MH  - *Nurse's Role/psychology
MH  - Nursing Research
MH  - *Nursing Theory
MH  - *Philosophy, Nursing
MH  - Research Design
MH  - *Virtues
EDAT- 2010/08/31 06:00
MHDA- 2011/02/12 06:00
CRDT- 2010/08/31 06:00
PHST- 2010/08/31 06:00 [entrez]
PHST- 2010/08/31 06:00 [pubmed]
PHST- 2011/02/12 06:00 [medline]
AID - 17/5/551 [pii]
AID - 10.1177/0969733010369475 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 Sep;17(5):551-65. doi: 10.1177/0969733010369475.


PMID- 20801955
OWN - NLM
STAT- MEDLINE
DCOM- 20110211
LR  - 20100830
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 5
DP  - 2010 Sep
TI  - Clinical ethics and challenges to individualized care.
PG  - 541-2
LID - 10.1177/0969733010373999 [doi]
FAU - Suhonen, Riitta
AU  - Suhonen R
LA  - eng
PT  - Editorial
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Communication
MH  - *Ethics, Nursing
MH  - Humans
MH  - Nurse's Role
MH  - Nurse-Patient Relations/ethics
MH  - Patient Advocacy/*ethics
MH  - Patient Care Planning/*ethics
MH  - Patient Participation
EDAT- 2010/08/31 06:00
MHDA- 2011/02/12 06:00
CRDT- 2010/08/31 06:00
PHST- 2010/08/31 06:00 [entrez]
PHST- 2010/08/31 06:00 [pubmed]
PHST- 2011/02/12 06:00 [medline]
AID - 17/5/541 [pii]
AID - 10.1177/0969733010373999 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 Sep;17(5):541-2. doi: 10.1177/0969733010373999.


PMID- 20801954
OWN - NLM
STAT- MEDLINE
DCOM- 20110211
LR  - 20141120
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 5
DP  - 2010 Sep
TI  - The ethics of mutuality.
PG  - 539-40
LID - 10.1177/0969733010375875 [doi]
FAU - Gallagher, Ann
AU  - Gallagher A
LA  - eng
PT  - Editorial
PT  - Introductory Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Congresses as Topic
MH  - *Cooperative Behavior
MH  - Croatia
MH  - *Ethics, Nursing
MH  - *Global Health
MH  - Humans
MH  - *International Cooperation
MH  - *Interprofessional Relations
EDAT- 2010/08/31 06:00
MHDA- 2011/02/12 06:00
CRDT- 2010/08/31 06:00
PHST- 2010/08/31 06:00 [entrez]
PHST- 2010/08/31 06:00 [pubmed]
PHST- 2011/02/12 06:00 [medline]
AID - 17/5/539 [pii]
AID - 10.1177/0969733010375875 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 Sep;17(5):539-40. doi: 10.1177/0969733010375875.


PMID- 20801448
OWN - NLM
STAT- MEDLINE
DCOM- 20110330
LR  - 20161229
IS  - 1879-3479 (Electronic)
IS  - 0020-7292 (Linking)
VI  - 111
IP  - 2
DP  - 2010 Nov
TI  - Cross-border reproductive services: FIGO Committee for the Ethical Aspects of
      Human Reproduction and Women's Health.
PG  - 190-1
LID - 10.1016/j.ijgo.2010.07.005 [doi]
FAU - Dickens, Bernard
AU  - Dickens B
AD  - figo@figo.org
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Int J Gynaecol Obstet
JT  - International journal of gynaecology and obstetrics: the official organ of the
      International Federation of Gynaecology and Obstetrics
JID - 0210174
SB  - IM
MH  - Emigration and Immigration
MH  - *Ethics Committees, Clinical
MH  - Female
MH  - Humans
MH  - Infertility, Female/*therapy
MH  - Pregnancy
MH  - Reproductive Techniques, Assisted/*ethics/legislation & jurisprudence
MH  - Women's Health/*ethics/legislation & jurisprudence
EDAT- 2010/08/31 06:00
MHDA- 2011/03/31 06:00
CRDT- 2010/08/31 06:00
PHST- 2010/08/31 06:00 [entrez]
PHST- 2010/08/31 06:00 [pubmed]
PHST- 2011/03/31 06:00 [medline]
AID - S0020-7292(10)00375-9 [pii]
AID - 10.1016/j.ijgo.2010.07.005 [doi]
PST - ppublish
SO  - Int J Gynaecol Obstet. 2010 Nov;111(2):190-1. doi: 10.1016/j.ijgo.2010.07.005.


PMID- 20801443
OWN - NLM
STAT- MEDLINE
DCOM- 20110330
LR  - 20161229
IS  - 1879-3479 (Electronic)
IS  - 0020-7292 (Linking)
VI  - 111
IP  - 2
DP  - 2010 Nov
TI  - Disclosing adverse outcomes in medical care: FIGO Committee for the Ethical
      Aspects of Human Reproduction and Women's Health.
PG  - 192
LID - 10.1016/j.ijgo.2010.07.006 [doi]
FAU - Dickens, Bernard
AU  - Dickens B
AD  - figo@figo.org
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Int J Gynaecol Obstet
JT  - International journal of gynaecology and obstetrics: the official organ of the
      International Federation of Gynaecology and Obstetrics
JID - 0210174
SB  - IM
MH  - *Ethics Committees, Clinical
MH  - Female
MH  - Humans
MH  - Patient Care/*adverse effects
MH  - Physician-Patient Relations/*ethics
MH  - *Truth Disclosure
MH  - Women's Health/*ethics/legislation & jurisprudence
EDAT- 2010/08/31 06:00
MHDA- 2011/03/31 06:00
CRDT- 2010/08/31 06:00
PHST- 2010/08/31 06:00 [entrez]
PHST- 2010/08/31 06:00 [pubmed]
PHST- 2011/03/31 06:00 [medline]
AID - S0020-7292(10)00376-0 [pii]
AID - 10.1016/j.ijgo.2010.07.006 [doi]
PST - ppublish
SO  - Int J Gynaecol Obstet. 2010 Nov;111(2):192. doi: 10.1016/j.ijgo.2010.07.006.


PMID- 20800084
OWN - NLM
STAT- MEDLINE
DCOM- 20110623
LR  - 20131121
IS  - 1096-0295 (Electronic)
IS  - 0273-2300 (Linking)
VI  - 58
IP  - 3
DP  - 2010 Dec
TI  - Benchmark dose approaches in chemical health risk assessment in relation to
      number and distress of laboratory animals.
PG  - 451-4
LID - 10.1016/j.yrtph.2010.08.015 [doi]
AB  - Use of benchmark dose (BMD) approaches is expected to increase substantially,
      with growing awareness among researchers and inclusion in regulatory testing
      guidance documents such as REACH. The BMD approach has clear advantages over the 
      No-Observed-Adverse-Effect-Level (NOAEL) approach in defining toxicological
      thresholds, risk levels, and points of departure as the basis for setting
      guidance and limit values. Several aspects of the BMD may increase the use of
      laboratory animals; the optimal number of dose groups for BMD calculation is
      between five and ten, rather than the current standard of four; also, experiments
      with more animals will result in narrow confidence intervals. However, this paper
      presents several counterarguments suggesting that design of experiments suited
      for BMD analyses might be used to decrease the distress and use of laboratory
      animals. If experiments are performed with unequal group size, with fewer animals
      in the high response dose groups and more animals close to toxicological
      threshold, the aggregated distress might be reduced. In addition, there is a need
      to evaluate how the total number of animals affects the quality of BMD (e.g. in
      terms of confidence intervals). Development of strategies for optimal design of
      experiments requires tools which evaluate experimental designs from an ethical
      perspective; a concept of distress-adjusted number of animals is suggested.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Oberg, Mattias
AU  - Oberg M
AD  - Institute of Environmental Medicine, Karolinska Institutet, P.O. Box 210, SE-171 
      77 Stockholm, Sweden. mattias.oberg@ki.se
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100825
PL  - Netherlands
TA  - Regul Toxicol Pharmacol
JT  - Regulatory toxicology and pharmacology : RTP
JID - 8214983
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Animals
MH  - Animals, Laboratory
MH  - Benchmarking
MH  - Dose-Response Relationship, Drug
MH  - *Drug-Related Side Effects and Adverse Reactions
MH  - Models, Statistical
MH  - No-Observed-Adverse-Effect Level
MH  - Pharmaceutical Preparations/administration & dosage
MH  - Research Design
MH  - Risk Assessment
MH  - Toxicity Tests/*methods
EDAT- 2010/08/31 06:00
MHDA- 2011/06/24 06:00
CRDT- 2010/08/31 06:00
PHST- 2010/06/15 00:00 [received]
PHST- 2010/08/18 00:00 [revised]
PHST- 2010/08/19 00:00 [accepted]
PHST- 2010/08/31 06:00 [entrez]
PHST- 2010/08/31 06:00 [pubmed]
PHST- 2011/06/24 06:00 [medline]
AID - S0273-2300(10)00142-X [pii]
AID - 10.1016/j.yrtph.2010.08.015 [doi]
PST - ppublish
SO  - Regul Toxicol Pharmacol. 2010 Dec;58(3):451-4. doi: 10.1016/j.yrtph.2010.08.015. 
      Epub 2010 Aug 25.


PMID- 20799672
OWN - NLM
STAT- MEDLINE
DCOM- 20101005
LR  - 20170214
IS  - 0020-7314 (Print)
IS  - 0020-7314 (Linking)
VI  - 40
IP  - 3
DP  - 2010
TI  - The good, the bad, and the ugly of partnered research: revisiting the
      sequestration thesis and the role of universities in promoting social justice.
PG  - 485-505
AB  - As universities increasingly rely on external sources of research funding,
      researchers worldwide are realizing that if their work is financially supported
      by organizations with distinct political or financial interests, they risk their 
      careers if their results deviate from the interests of their funding partners.
      This article presents a case that illustrates how ugly this situation can become.
      Reviewing the literature on the advantages and dangers of partnered research, the
      historical role of universities, funding trends, and university mission
      statements, the authors contend that universities must engage in service learning
      and participatory action research, but must ensure that faculty members engaging 
      in academic activity with partners-whether industry, hospitals, governments,
      nongovernmental organizations, or communities-have their professional integrity
      protected. If doubt exists about whether the partner can or will honor these
      principles or the mission of universities for social good, universities should
      avoid granting joint or affiliate appointments or accepting funds or favors of
      any kind. Universities also need formal structures to ensure ethical application 
      of innovation and principled partnership engagement. In becoming servants of
      government or corporatism, universities have become less vital to society and are
      failing in their mission to promote social justice and sustainability. Strong
      measures are needed to restore public trust.
FAU - Yassi, Annalee
AU  - Yassi A
AD  - College for Interdisciplinary Studies, School of Population and Public Health,
      University of British Columbia, Vancouver, Canada. annalee.yassi@ubc.ca
FAU - Dharamsi, Shafik
AU  - Dharamsi S
FAU - Spiegel, Jerry
AU  - Spiegel J
FAU - Rojas, Alejandro
AU  - Rojas A
FAU - Dean, Elizabeth
AU  - Dean E
FAU - Woollard, Robert
AU  - Woollard R
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Health Serv
JT  - International journal of health services : planning, administration, evaluation
JID - 1305035
SB  - IM
MH  - *Cooperative Behavior
MH  - Ethics, Research
MH  - Financial Support
MH  - Humans
MH  - *Interinstitutional Relations
MH  - Models, Theoretical
MH  - *Role
MH  - *Social Justice
MH  - *Universities
EDAT- 2010/08/31 06:00
MHDA- 2010/10/06 06:00
CRDT- 2010/08/31 06:00
PHST- 2010/08/31 06:00 [entrez]
PHST- 2010/08/31 06:00 [pubmed]
PHST- 2010/10/06 06:00 [medline]
AID - 10.2190/HS.40.3.f [doi]
PST - ppublish
SO  - Int J Health Serv. 2010;40(3):485-505. doi: 10.2190/HS.40.3.f.


PMID- 22371808
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1896-9151 (Electronic)
IS  - 1734-1922 (Linking)
VI  - 6
IP  - 4
DP  - 2010 Aug 30
TI  - Analysis of demographic and clinical factors affecting the outcome of radioiodine
      therapy in patients with hyperthyroidism.
PG  - 611-6
LID - 10.5114/aoms.2010.14476 [doi]
AB  - INTRODUCTION: The influence of demographic and clinical factors on the outcome of
      (131)I therapy in hyperthyroid patients has been examined, based on a
      retrospective evaluation of results obtained in patients submitted to (131)I
      treatment at the Department of Nuclear Medicine and Oncological Endocrinology,
      Medical University of Lodz (Province Hospital, Zgierz). The goal of the study was
      to analyse such factors as the age and sex of patients, disease duration, as well
      as the hormonal status before (131)I application, which could have an influence
      on the effects of therapy with radioiodine (131)I. MATERIAL AND METHODS: The
      study involved 500 randomly selected patients with hyperthyroidism, treated with 
      (131)I radioiodine. The following 3 groups were defined: group 1 - patients with 
      multinodular goitre (MNG), n = 200; group 2 - patients with a single autonomous
      nodule of the thyroid (AFTN), n = 100; group 3 - patients with Graves' disease
      (GD), n = 200. The local ethics committee (in the Polish Mother's Memorial
      Hospital - Research Institute, Lodz) approved the study. RESULTS: The obtained
      results indicate that the efficacy of therapy with (131)I applied in patients
      with MNG, AFTN and GD does not depend on either patient sex or patient age. The
      length of antithyroid treatment before (131)I therapy onset does not appear to
      have any effect on the therapy outcome, and the baseline thyrotropin
      concentration seems to be significant only in the case of GD. CONCLUSIONS: The
      analysed demographic factors do not affect the outcome of (131)I therapy in
      hyperthyroidism.
FAU - Knapska-Kucharska, Malgorzata
AU  - Knapska-Kucharska M
AD  - Department of Nuclear Medicine and Oncological Endocrinology, Lodz, Poland.
FAU - Oszukowska, Lidia
AU  - Oszukowska L
FAU - Lewinski, Andrzej
AU  - Lewinski A
LA  - eng
PT  - Journal Article
DEP - 20100907
PL  - Poland
TA  - Arch Med Sci
JT  - Archives of medical science : AMS
JID - 101258257
PMC - PMC3284079
OTO - NOTNLM
OT  - 131I radioiodine therapy
OT  - hyperthyroidism
OT  - thyroid
EDAT- 2010/08/30 00:00
MHDA- 2010/08/30 00:01
CRDT- 2012/02/29 06:00
PHST- 2008/11/07 00:00 [received]
PHST- 2008/12/15 00:00 [revised]
PHST- 2008/12/30 00:00 [accepted]
PHST- 2012/02/29 06:00 [entrez]
PHST- 2010/08/30 00:00 [pubmed]
PHST- 2010/08/30 00:01 [medline]
AID - 10.5114/aoms.2010.14476 [doi]
AID - 15187 [pii]
PST - ppublish
SO  - Arch Med Sci. 2010 Aug 30;6(4):611-6. doi: 10.5114/aoms.2010.14476. Epub 2010 Sep
      7.


PMID- 20799112
OWN - NLM
STAT- MEDLINE
DCOM- 20101213
LR  - 20140502
IS  - 1532-4826 (Electronic)
IS  - 0908-4282 (Linking)
VI  - 17
IP  - 3
DP  - 2010 Jul
TI  - Notation of professional qualifications and affiliations: avoiding puffery and
      deception.
PG  - 205-9
LID - 10.1080/09084282.2010.499793 [doi]
AB  - Neuropsychologists are ethically charged with communicating their qualifications 
      and credentials in ways that promote understanding and avoid deception. However, 
      there exist few if any concrete guidelines about how and when to cite
      qualifications when rendering professional neuropsychological opinions. This
      article attempts to clarify the issues relevant to the signatory process,
      offering guidelines based on principles of accuracy, relevancy, and necessity.
      Common practices and problems are outlined, and recommended solutions offered.
FAU - Meharg, Stephen S
AU  - Meharg SS
AD  - Center for Memory and Learning, 945 11th Avenue, Longview, WA 98632, USA.
      smeharg@cfmal.com
FAU - Bush, Shane S
AU  - Bush SS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Appl Neuropsychol
JT  - Applied neuropsychology
JID - 9507620
SB  - IM
MH  - *Ethics, Professional
MH  - *Guidelines as Topic
MH  - Humans
MH  - Neuropsychology/*standards
MH  - Organizational Affiliation
MH  - Psychology/*standards
EDAT- 2010/08/28 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/28 06:00
PHST- 2010/08/28 06:00 [entrez]
PHST- 2010/08/28 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 926372025 [pii]
AID - 10.1080/09084282.2010.499793 [doi]
PST - ppublish
SO  - Appl Neuropsychol. 2010 Jul;17(3):205-9. doi: 10.1080/09084282.2010.499793.


PMID- 20799055
OWN - NLM
STAT- MEDLINE
DCOM- 20110127
LR  - 20211020
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 22
IP  - 3
DP  - 2010 Sep
TI  - Introduction: HEC Forum special issue on privacy and commodification.
PG  - 173-7
LID - 10.1007/s10730-010-9135-4 [doi]
AB  - The papers in this special thematic issue of HEC Forum critically and carefully
      explore key issues at the intersection of patient privacy and commodification.
      For example, should hospitals be required to secure a person's consent to any
      possible uses to which his discarded body parts might be put after his treatment 
      or should it only be concerned with securing his informed consent to his
      treatment? Should a hospital be required to raise the possibility of the
      commodification of such (patient-discarded) body parts, or should it only be
      required to address this issue if the patient asks about it? Should persons be
      paid to engage in medical research, or should they only be compensated for their 
      time, on the grounds, perhaps, that such payment would be coercive or
      exploitative, for it might move some persons to agree to participate in research 
      who otherwise would not have done? This number of HEC Forum illustrates the
      widespread implications of these issues upon which healthcare ethics committees
      are called to deliberate.
FAU - Taylor, James Stacey
AU  - Taylor JS
AD  - Department of Philosophy, The College of New Jersey, 2000 Pennington Road, Ewing,
      NJ 08628, USA. jtaylor@tcnj.edu
LA  - eng
PT  - Introductory Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - *Biomedical Research
MH  - Human Body
MH  - Humans
MH  - Informed Consent
MH  - *Ownership
MH  - *Privacy
EDAT- 2010/08/28 06:00
MHDA- 2011/01/29 06:00
CRDT- 2010/08/28 06:00
PHST- 2010/08/28 06:00 [entrez]
PHST- 2010/08/28 06:00 [pubmed]
PHST- 2011/01/29 06:00 [medline]
AID - 10.1007/s10730-010-9135-4 [doi]
PST - ppublish
SO  - HEC Forum. 2010 Sep;22(3):173-7. doi: 10.1007/s10730-010-9135-4.


PMID- 20799054
OWN - NLM
STAT- MEDLINE
DCOM- 20110127
LR  - 20100917
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 22
IP  - 3
DP  - 2010 Sep
TI  - Commodification and privacy: a Lockean perspective.
PG  - 179-95
LID - 10.1007/s10730-010-9136-3 [doi]
AB  - This paper defends the thesis that privacy as a right is derived from fundamental
      rights to life, liberty, and property and does not permit restricting the
      commodification of bodily material; however, privacy as life, liberty, property
      does require conventions that ensure a robust and just market in bodily material.
      The analysis proceeds by defending a general commitment to liberty and markets,
      but not in the manner one might expect from a 'doctrinaire' libertarian. Ethical 
      concerns about commodification are legitimate in the context of new medical and
      information technologies, but these concerns are not sufficiently well defined to
      justify political conclusions, since not every ethical concern is in itself a
      political concern, and the best way to resolve certain ethical difficulties is to
      draw up political boundaries that facilitate the discovery and testing of various
      solutions to our ethical puzzles. To illustrate the point, I will indicate how
      privacy as life, liberty, property defines such a dynamic solution to the
      problems of commodification of human bodily material and slippery information in 
      insurance markets.
FAU - Volkman, Richard
AU  - Volkman R
AD  - Department of Philosophy, Research Center on Computing and Society, Southern
      Connecticut State University, 501 Crescent Street, New Haven, CT 06515, USA.
      volkmanr1@southernct.edu
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - Civil Rights
MH  - Commerce
MH  - Human Body
MH  - Humans
MH  - *Ownership
MH  - Politics
MH  - *Privacy
EDAT- 2010/08/28 06:00
MHDA- 2011/01/29 06:00
CRDT- 2010/08/28 06:00
PHST- 2010/08/28 06:00 [entrez]
PHST- 2010/08/28 06:00 [pubmed]
PHST- 2011/01/29 06:00 [medline]
AID - 10.1007/s10730-010-9136-3 [doi]
PST - ppublish
SO  - HEC Forum. 2010 Sep;22(3):179-95. doi: 10.1007/s10730-010-9136-3.


PMID- 20799051
OWN - NLM
STAT- MEDLINE
DCOM- 20110127
LR  - 20211020
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 22
IP  - 3
DP  - 2010 Sep
TI  - Do no harm: a defense of markets in healthcare.
PG  - 241-51
LID - 10.1007/s10730-010-9140-7 [doi]
AB  - This paper argues that the rules that constitute a market protect autonomy and
      increase welfare in healthcare. Markets do the former through protecting rights
      to self-ownership and a cluster of rights that protect its exercise. Markets
      protect welfare by organizing and protecting trades. In contrast, prohibition
      destroys legitimate markets, giving rise to so-called black markets that harm
      both the autonomy and well-being of agents. For example, a fee-for-service
      medical system is a highly developed and specialized market. It is individuals
      working together, through the division of labor, to provide mutual insurance.
      This coordination, and the benefits it makes possible, is not possible without
      injunctions against harm. Prohibitions on harm are not mere ethical niceties,
      they are practice rules for both healthcare and markets. Placing the doctor
      within a healthcare market actually reinforces the doctor's moral obligation, and
      the legal enforcement of that obligation, not to harm. Similarly, markets
      reinforce patient rights to self-determination through legal and institutional
      enforcement of the harm principle in the form of the protection of certain basic 
      welfare rights to life, bodily integrity, property, trade, and contract. Since
      the establishment of markets protects agent autonomy and welfare, and prohibition
      directly harms the same, there are strong reasons for establishing markets to
      protect trade in precisely those areas where autonomy and well-being are most
      vulnerable to exploitation, for example, the trade in human kidneys.
FAU - Kline, William
AU  - Kline W
AD  - Liberal and Integrative Studies, University of Illinois at Springfield, One
      University Plaza, MS UH3038, Springfield, IL 62794-9293, USA. wklin2@uis.edu
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - Fee-for-Service Plans
MH  - Fraud
MH  - *Harm Reduction
MH  - *Health Care Sector
MH  - Humans
MH  - Kidney Transplantation
MH  - Personal Autonomy
MH  - Physician's Role
MH  - Tissue and Organ Procurement
EDAT- 2010/08/28 06:00
MHDA- 2011/01/29 06:00
CRDT- 2010/08/28 06:00
PHST- 2010/08/28 06:00 [entrez]
PHST- 2010/08/28 06:00 [pubmed]
PHST- 2011/01/29 06:00 [medline]
AID - 10.1007/s10730-010-9140-7 [doi]
PST - ppublish
SO  - HEC Forum. 2010 Sep;22(3):241-51. doi: 10.1007/s10730-010-9140-7.


PMID- 20798843
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 2090-0252 (Electronic)
VI  - 2010
DP  - 2010 Jun 27
TI  - To know or not to know: ethical issues related to early diagnosis of Alzheimer's 
      disease.
LID - 10.4061/2010/841941 [doi]
LID - 841941 [pii]
AB  - In Alzheimer's disease (AD), pathological processes start in the brain long
      before clinical dementia. Biomarkers reflecting brain alterations may therefore
      indicate disease at an early stage, enabling early diagnosis. This raises several
      ethical questions and the potential benefits of early diagnosis must be weighted 
      against possible disadvantages. Currently, there are few strong arguments
      favouring early diagnosis, due to the lack of disease modifying therapy. Also,
      available diagnostic methods risk erroneous classifications, with potentially
      grave consequences. However, a possible benefit of early diagnosis even without
      disease modifying therapy is that it may enable early decision making when
      patients still have full decision competence, avoiding problems of hypothetical
      consents. It may also help identifying patients with cognitive dysfunction
      secondary to other diseases that may be responsive to treatment already today.
FAU - Mattsson, Niklas
AU  - Mattsson N
AD  - Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology,
      Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at
      University of Gothenburg, Gothenburg, 431 80 Molndal, Sweden.
FAU - Brax, David
AU  - Brax D
FAU - Zetterberg, Henrik
AU  - Zetterberg H
LA  - eng
PT  - Journal Article
DEP - 20100627
PL  - United States
TA  - Int J Alzheimers Dis
JT  - International journal of Alzheimer's disease
JID - 101525141
PMC - PMC2925376
EDAT- 2010/08/28 06:00
MHDA- 2010/08/28 06:01
CRDT- 2010/08/28 06:00
PHST- 2010/04/19 00:00 [received]
PHST- 2010/05/07 00:00 [accepted]
PHST- 2010/08/28 06:00 [entrez]
PHST- 2010/08/28 06:00 [pubmed]
PHST- 2010/08/28 06:01 [medline]
AID - 10.4061/2010/841941 [doi]
PST - epublish
SO  - Int J Alzheimers Dis. 2010 Jun 27;2010. doi: 10.4061/2010/841941.


PMID- 20798495
OWN - NLM
STAT- MEDLINE
DCOM- 20101208
LR  - 20190212
IS  - 1421-9778 (Electronic)
IS  - 1015-8987 (Linking)
VI  - 26
IP  - 2
DP  - 2010
TI  - Induced pluripotent stem cells: a new approach for physiological research.
PG  - 105-24
LID - 10.1159/000320514 [doi]
AB  - The generation of induced pluripotent stem (iPS) cells by controlled delivery of 
      reprogramming factors enables the derivation of pluripotent cells from a variety 
      of somatic cell types. Patient-tailored iPS cells remove the major roadblock of
      immune rejection for clinical applications associated with the use of human
      embryonic stem (hES) cells. Beside therapeutic issues, iPS cell technology opens 
      the door for broader research on human pluripotent cells because ethical
      limitations are lifted with iPS cells compared to hES cells. Scientists are now
      able to generate iPS cells for disease modelling and use them in basic research
      of physiological and pathophysiological models. In this concise review, we
      discuss the state of the art in the field of iPS cell induction by cell fusion or
      defined factors. Techniques to derive pluripotent cells from somatic sources are 
      introduced and discussed, as well as some biological factors that influence the
      generation of iPS cells. We compare ES and iPS cells to answer the question
      whether these cells are identical, and we finish with an outlook on clinical
      research with iPS cells with a focus on cardiovascular medicine.
CI  - Copyright 2010 S. Karger AG, Basel.
FAU - Pfannkuche, Kurt
AU  - Pfannkuche K
AD  - Institute for Neurophysiology, University of Cologne, Germany.
      Kurt.Pfannkuche@uni-koeln.de
FAU - Hannes, Tobias
AU  - Hannes T
FAU - Khalil, Markus
AU  - Khalil M
FAU - Noghabi, Monireh Soroush
AU  - Noghabi MS
FAU - Morshedi, Amir
AU  - Morshedi A
FAU - Hescheler, Jurgen
AU  - Hescheler J
FAU - Droge, Peter
AU  - Droge P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100824
PL  - Germany
TA  - Cell Physiol Biochem
JT  - Cellular physiology and biochemistry : international journal of experimental
      cellular physiology, biochemistry, and pharmacology
JID - 9113221
SB  - IM
MH  - Animals
MH  - Cardiovascular Diseases/therapy
MH  - Cellular Reprogramming
MH  - Embryonic Stem Cells/physiology
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*physiology
MH  - Mice
EDAT- 2010/08/28 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/28 06:00
PHST- 2010/06/24 00:00 [accepted]
PHST- 2010/08/28 06:00 [entrez]
PHST- 2010/08/28 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 000320514 [pii]
AID - 10.1159/000320514 [doi]
PST - ppublish
SO  - Cell Physiol Biochem. 2010;26(2):105-24. doi: 10.1159/000320514. Epub 2010 Aug
      24.


PMID- 20798369
OWN - NLM
STAT- MEDLINE
DCOM- 20101019
LR  - 20161122
IS  - 1524-4628 (Electronic)
IS  - 0039-2499 (Linking)
VI  - 41
IP  - 10
DP  - 2010 Oct
TI  - Flow-diverter stent for the endovascular treatment of intracranial aneurysms: a
      prospective study in 29 patients with 34 aneurysms.
PG  - 2247-53
LID - 10.1161/STROKEAHA.110.589911 [doi]
AB  - BACKGROUND AND PURPOSE: The purpose of this study is to report our preliminary
      experience with the flow-diverter Silk stent for the endovascular treatment of
      intracranial aneurysms. METHODS: This prospective study was approved by the
      authors' ethical committees. Twenty-nine patients with 34 fusiform or wide-necked
      unruptured aneurysms were included and treated by Silk stent placement alone by 2
      physicians in 3 different centers. Technical issues, immediate findings, delayed 
      complications, clinical follow-up, and imaging follow-up at 3 and 6 months were
      assessed. RESULTS: Endovascular treatment was successfully performed in 26
      patients (90%). In 3 patients, the stent could not be delivered. Mortality and
      morbidity rates were of 4% (1 of 26) and 15% (4 of 26), respectively; 1 patient
      died from a delayed aneurysm rupture related to stent migration, 3 experienced a 
      thromboembolic event, and 1 patient developed progressive visual disturbances
      related to an increased mass effect. Clinical outcome in 25 patients was
      unchanged (n=19), improved (n=2), or worsened (=4). Angiographic follow-up in 24 
      patients (29 aneurysms) showed 20 complete occlusions (69%), 1 neck remnant
      (3.5%), and 8 incomplete occlusions (27.5%). Significant parent artery stenosis
      at 6 months occurred in 8 cases (33%). CONCLUSIONS: Despite the potential
      interest of the Silk flow-diverter stent to treat complex intracranial aneurysms 
      without coils, the delayed complication rate is quite high and leads to use this 
      technique only in selective cases.
FAU - Lubicz, Boris
AU  - Lubicz B
AD  - Departments of Neuroradiology, Erasme University Hospital, Brussels, Belgium.
      blubicz@ulb.ac.be
FAU - Collignon, Laurent
AU  - Collignon L
FAU - Raphaeli, Gai
AU  - Raphaeli G
FAU - Pruvo, Jean-Pierre
AU  - Pruvo JP
FAU - Bruneau, Michael
AU  - Bruneau M
FAU - De Witte, Olivier
AU  - De Witte O
FAU - Leclerc, Xavier
AU  - Leclerc X
LA  - eng
PT  - Journal Article
DEP - 20100826
PL  - United States
TA  - Stroke
JT  - Stroke
JID - 0235266
SB  - IM
CIN - Stroke. 2011 Mar;42(3):e38-9; author reply e40. PMID: 21293021
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cerebral Angiography
MH  - Child
MH  - Female
MH  - Humans
MH  - Intracranial Aneurysm/*surgery
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Prosthesis Implantation/*adverse effects
MH  - Stents/*adverse effects
MH  - Treatment Outcome
EDAT- 2010/08/28 06:00
MHDA- 2010/10/20 06:00
CRDT- 2010/08/28 06:00
PHST- 2010/08/28 06:00 [entrez]
PHST- 2010/08/28 06:00 [pubmed]
PHST- 2010/10/20 06:00 [medline]
AID - STROKEAHA.110.589911 [pii]
AID - 10.1161/STROKEAHA.110.589911 [doi]
PST - ppublish
SO  - Stroke. 2010 Oct;41(10):2247-53. doi: 10.1161/STROKEAHA.110.589911. Epub 2010 Aug
      26.


PMID- 20797979
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20211020
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 10
DP  - 2010 Oct
TI  - Developing a problem-based learning (PBL) curriculum for professionalism and
      scientific integrity training for biomedical graduate students.
PG  - 614-9
LID - 10.1136/jme.2009.035220 [doi]
AB  - A multidisciplinary faculty committee designed a curriculum to shape biomedical
      graduate students into researchers with a high commitment to professionalism and 
      social responsibility and to provide students with tools to navigate complex,
      rapidly evolving academic and societal environments with a strong ethical
      commitment. The curriculum used problem-based learning (PBL), because it is
      active and learner-centred and focuses on skill and process development. Two
      courses were developed: Scientific Professionalism: Scientific Integrity
      addressed discipline-specific and broad professional norms and obligations for
      the ethical practice of science and responsible conduct of research (RCR).
      Scientific Professionalism: Bioethics and Social Responsibility focused on
      current ethical and bioethical issues within the scientific profession, and
      implications of research for society. Each small-group session examined case
      scenarios that included: (1) learning objectives for professional norms and
      obligations; (2) key ethical issues and philosophies within each topic area; (3) 
      one or more of the RCR instructional areas; and (4) at least one type of moral
      reflection. Cases emphasised professional standards, obligations and underlying
      philosophies for the ethical practice of science, competing interests of
      stakeholders and oversight of science (internal and external). To our knowledge, 
      this is the first use of a longitudinal, multi-semester PBL course to teach
      scientific integrity and professionalism. Both faculty and students endorsed the 
      active learning approach for these topics, in contrast to a compliance-based
      approach that emphasises learning rules and regulations.
FAU - Jones, Nancy L
AU  - Jones NL
AD  - Division Public Health Sciences, Wake Forest University Health Sciences,
      Winston-Salem, North Carolina, USA. jonesna@niaid.nih.gov
FAU - Peiffer, Ann M
AU  - Peiffer AM
FAU - Lambros, Ann
AU  - Lambros A
FAU - Guthold, Martin
AU  - Guthold M
FAU - Johnson, A Daniel
AU  - Johnson AD
FAU - Tytell, Michael
AU  - Tytell M
FAU - Ronca, April E
AU  - Ronca AE
FAU - Eldridge, J Charles
AU  - Eldridge JC
LA  - eng
GR  - F32 NS054472/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20100825
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Bioethical Issues
MH  - Biomedical Research/education/ethics
MH  - *Curriculum
MH  - Education, Medical, Graduate/*methods
MH  - Ethics, Medical/*education
MH  - Humans
MH  - *Morals
MH  - Problem-Based Learning/*methods/organization & administration
MH  - *Professional Practice/standards
PMC - PMC3809997
MID - NIHMS402459
EDAT- 2010/08/28 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/08/28 06:00
PHST- 2010/08/28 06:00 [entrez]
PHST- 2010/08/28 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - jme.2009.035220 [pii]
AID - 10.1136/jme.2009.035220 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Oct;36(10):614-9. doi: 10.1136/jme.2009.035220. Epub 2010 Aug 
      25.


PMID- 20797976
OWN - NLM
STAT- MEDLINE
DCOM- 20110315
LR  - 20101129
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 12
DP  - 2010 Dec
TI  - A comparative analysis of biomedical research ethics regulation systems in Europe
      and Latin America with regard to the protection of human subjects.
PG  - 750-3
LID - 10.1136/jme.2009.035097 [doi]
AB  - The European project European and Latin American Systems of Ethics Regulation of 
      Biomedical Research Project (EULABOR) has carried out the first comparative
      analysis of ethics regulation systems for biomedical research in seven countries 
      in Europe and Latin America, evaluating their roles in the protection of human
      subjects. We developed a conceptual and methodological framework defining 'ethics
      regulation system for biomedical research' as a set of actors, institutions,
      codes and laws involved in overseeing the ethics of biomedical research on
      humans. This framework allowed us to develop comprehensive national reports by
      conducting semi-structured interviews to key informants. These reports were
      summarised and analysed in a comparative analysis. The study showed that the
      regulatory framework for clinical research in these countries differ in scope. It
      showed that despite the different political contexts, actors involved and
      motivations for creating the regulation, in most of the studied countries it was 
      the government who took the lead in setting up the system. The study also showed 
      that Europe and Latin America are similar regarding national bodies and research 
      ethics committees, but the Brazilian system has strong and noteworthy
      specificities.
FAU - Lamas, Eugenia
AU  - Lamas E
AD  - INSERM, 101 rue de Tolbiac, 75654 Paris Cedex 13, France. eugenia.lamas@inserm.fr
FAU - Ferrer, Marcela
AU  - Ferrer M
FAU - Molina, Alberto
AU  - Molina A
FAU - Salinas, Rodrigo
AU  - Salinas R
FAU - Hevia, Adriana
AU  - Hevia A
FAU - Bota, Alexandre
AU  - Bota A
FAU - Feinholz, Dafna
AU  - Feinholz D
FAU - Fuchs, Michael
AU  - Fuchs M
FAU - Schramm, Roland
AU  - Schramm R
FAU - Tealdi, Juan-Carlos
AU  - Tealdi JC
FAU - Zorrilla, Sergio
AU  - Zorrilla S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100826
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Bioethics
MH  - Biomedical Research/*ethics/legislation & jurisprudence
MH  - Ethics Committees, Research
MH  - *Ethics, Research
MH  - Europe
MH  - *Government Regulation
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Latin America
MH  - Research Subjects/legislation & jurisprudence
EDAT- 2010/08/28 06:00
MHDA- 2011/03/16 06:00
CRDT- 2010/08/28 06:00
PHST- 2010/08/28 06:00 [entrez]
PHST- 2010/08/28 06:00 [pubmed]
PHST- 2011/03/16 06:00 [medline]
AID - jme.2009.035097 [pii]
AID - 10.1136/jme.2009.035097 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Dec;36(12):750-3. doi: 10.1136/jme.2009.035097. Epub 2010 Aug 
      26.


PMID- 20795851
OWN - NLM
STAT- MEDLINE
DCOM- 20101214
LR  - 20220408
IS  - 1875-9114 (Electronic)
IS  - 0277-0008 (Linking)
VI  - 30
IP  - 9
DP  - 2010 Sep
TI  - The essential research curriculum for doctor of pharmacy degree programs.
PG  - 966
LID - 10.1592/phco.30.9.966 [doi]
AB  - In 2008, the American College of Clinical Pharmacy appointed the Task Force on
      Research in the Professional Curriculum to review and make recommendations on the
      essential research curriculum that should be part of doctor of pharmacy
      (Pharm.D.) degree programs. The essential research curriculum provides all
      students with critical and analytical thinking and lifelong learning skills,
      which will apply to current and future practice and stimulate some students to
      pursue a career in this field. Eight key curricular competencies are as follows: 
      identifying relevant problems and gaps in pharmacotherapeutic knowledge;
      generating a research hypothesis; designing a study to test the hypothesis;
      analyzing data results using appropriate statistical tests; interpreting and
      applying the results of a research study to practice; effectively communicating
      research and clinical findings to pharmacy, medical, and basic science audiences;
      interpreting and effectively communicating research and clinical findings to
      patients and caregivers; and applying regulatory and ethical principles when
      conducting research or using research results. Faculty are encouraged to use
      research-related examples across the curriculum in nonresearch courses and to
      employ interactive teaching methods to promote student engagement. Examples of
      successful strategies used by Pharm.D. degree programs to integrate research
      content into the curriculum are provided. Current pharmacy school curricula allow
      variable amounts of time for instructional content in research, which may or may 
      not include hands-on experiences for students to develop research-related skills.
      Therefore, an important opportunity exists for schools to incorporate the
      essential research curriculum. Despite the challenges of implementing these
      recommendations, the essential research curriculum will position pharmacy school 
      graduates to understand the importance of research and its applications to
      practice. This perspective is provided as an aid and a challenge to those in
      leadership and teaching positions within schools and colleges of pharmacy.
CN  - American College of Clinical Pharmacy
FAU - Lee, Mary W
AU  - Lee MW
FAU - Clay, Patrick G
AU  - Clay PG
FAU - Kennedy, W Klugh
AU  - Kennedy WK
FAU - Kennedy, Mary Jayne
AU  - Kennedy MJ
FAU - Sifontis, Nicole M
AU  - Sifontis NM
FAU - Simonson, Dana
AU  - Simonson D
FAU - Sowinski, Kevin M
AU  - Sowinski KM
FAU - Taylor, William J
AU  - Taylor WJ
FAU - Teply, Robyn M
AU  - Teply RM
FAU - Vardeny, Orly
AU  - Vardeny O
FAU - Welty, Timothy E
AU  - Welty TE
LA  - eng
GR  - UL1 RR025011-03/RR/NCRR NIH HHS/United States
GR  - UL1 RR025011/RR/NCRR NIH HHS/United States
GR  - UL1 RR025011-02/RR/NCRR NIH HHS/United States
GR  - UL1 RR025011-05/RR/NCRR NIH HHS/United States
GR  - UL1 RR025011-01/RR/NCRR NIH HHS/United States
GR  - UL1 RR025011-04/RR/NCRR NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Pharmacotherapy
JT  - Pharmacotherapy
JID - 8111305
SB  - IM
MH  - *Curriculum
MH  - *Education, Pharmacy
MH  - Faculty
MH  - Learning
MH  - *Research
MH  - Schools, Pharmacy
MH  - Teaching
PMC - PMC3061314
MID - NIHMS274951
EDAT- 2010/08/28 06:00
MHDA- 2010/12/16 06:00
CRDT- 2010/08/28 06:00
PHST- 2010/08/28 06:00 [entrez]
PHST- 2010/08/28 06:00 [pubmed]
PHST- 2010/12/16 06:00 [medline]
AID - 10.1592/phco.30.9.966 [doi]
AID - 10.1592/phco.30.9.966 [pii]
PST - ppublish
SO  - Pharmacotherapy. 2010 Sep;30(9):966. doi: 10.1592/phco.30.9.966.


PMID- 20795837
OWN - NLM
STAT- MEDLINE
DCOM- 20110629
LR  - 20161125
IS  - 1469-9567 (Electronic)
IS  - 1356-1820 (Linking)
VI  - 25
IP  - 2
DP  - 2011 Mar
TI  - A city-wide approach to cross-boundary working with students with mental health
      needs.
PG  - 138-44
LID - 10.3109/13561820.2010.486875 [doi]
AB  - The aim of the research was to study a city-wide approach to meet the mental
      health needs of UK students involving a range of professional and
      non-professional support. The creation of a network for agencies and individuals 
      concerned with the mental health of students in further and higher education
      offered an opportunity to examine issues of access to services, transitions
      between services and the need for inter-agency working. The attitudes and
      experiences of a range of professional and non-professional providers of support 
      were explored using semi-structured interviews within a multiple case study
      methodological approach. Inter-agency working across professional and
      organisational boundaries was believed to offer the best means of enabling
      students with mental health needs to continue with their studies. However, issues
      of resources limitations, professional identities, work boundaries, role
      confusion, codes of ethics and confidentiality presented barriers to integrated
      support and inter-professional collaboration.
FAU - Leach, Jonathan
AU  - Leach J
AD  - Faculty of Health and Social Care, The Open University, Buckinghamshire, UK.
      j.s.r.leach@open.ac.uk
FAU - Hall, John
AU  - Hall J
LA  - eng
PT  - Journal Article
DEP - 20100826
PL  - England
TA  - J Interprof Care
JT  - Journal of interprofessional care
JID - 9205811
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Community Networks/*organization & administration
MH  - Health Services Accessibility/*organization & administration
MH  - Humans
MH  - Interinstitutional Relations
MH  - *Interprofessional Relations
MH  - Mental Health Services/*organization & administration
MH  - Students/psychology
MH  - United Kingdom
EDAT- 2010/08/28 06:00
MHDA- 2011/06/30 06:00
CRDT- 2010/08/28 06:00
PHST- 2010/08/28 06:00 [entrez]
PHST- 2010/08/28 06:00 [pubmed]
PHST- 2011/06/30 06:00 [medline]
AID - 10.3109/13561820.2010.486875 [doi]
PST - ppublish
SO  - J Interprof Care. 2011 Mar;25(2):138-44. doi: 10.3109/13561820.2010.486875. Epub 
      2010 Aug 26.


PMID- 20795612
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20101108
IS  - 0148-4834 (Print)
IS  - 0148-4834 (Linking)
VI  - 49
IP  - 11
DP  - 2010 Nov
TI  - Academic misconduct in nursing students: behaviors, attitudes, rationalizations, 
      and cultural identity.
PG  - 653-9
LID - 10.3928/01484834-20100831-03 [doi]
AB  - The purpose of this study was to gain knowledge about academic misconduct in
      associate degree nursing students enrolled in two nursing programs in the
      northeastern United States. Study respondents (n = 193) identified the frequency 
      of engagement in behaviors of misconduct in both the classroom and clinical
      setting and their attitudes toward the identified behaviors of misconduct,
      neutralization behaviors, ethical standards of the nursing profession, and the
      ethic of caring within the nursing profession. Findings were consistent with
      previous research on academic misconduct in baccalaureate nursing students.
      Analysis of self-reported cultural identities refuted the prevailing literature
      on academic misconduct across differing cultures and nations.
CI  - Copyright 2010, SLACK Incorporated.
FAU - McCrink, Andrea
AU  - McCrink A
AD  - Adelphi University, School of Nursing, Garden City, NY, USA. amccrink@adelphi.edu
LA  - eng
PT  - Journal Article
DEP - 20100831
PL  - United States
TA  - J Nurs Educ
JT  - The Journal of nursing education
JID - 7705432
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - *Attitude of Health Personnel/ethnology
MH  - Codes of Ethics
MH  - Confidentiality/ethics
MH  - *Deception
MH  - *Education, Nursing, Associate/organization & administration
MH  - Empathy
MH  - Female
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - New England
MH  - Patient Advocacy/ethics
MH  - Plagiarism
MH  - Professional Misconduct/ethics/*psychology/statistics & numerical data
MH  - *Rationalization
MH  - Social Identification
MH  - Students, Nursing/*psychology/statistics & numerical data
EDAT- 2010/08/28 06:00
MHDA- 2011/01/07 06:00
CRDT- 2010/08/28 06:00
PHST- 2009/08/11 00:00 [received]
PHST- 2010/02/10 00:00 [accepted]
PHST- 2010/08/28 06:00 [entrez]
PHST- 2010/08/28 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
AID - 10.3928/01484834-20100831-03 [doi]
PST - ppublish
SO  - J Nurs Educ. 2010 Nov;49(11):653-9. doi: 10.3928/01484834-20100831-03. Epub 2010 
      Aug 31.


PMID- 20795591
OWN - NLM
STAT- MEDLINE
DCOM- 20101021
LR  - 20141120
IS  - 0279-3695 (Print)
IS  - 0279-3695 (Linking)
VI  - 48
IP  - 9
DP  - 2010 Sep
TI  - Implications of an aging population for mental health nurses.
PG  - 15-8
LID - 10.3928/02793695-20100730-02 [doi]
AB  - The rapidly increasing numbers of older adults with dementia and other mental
      health problems throughout the world have huge ramifications for nurses who will 
      care for these individuals, as well as for health care systems. This article
      explores some current problems in the health care systems and makes suggestions
      for better, more efficient ways to meet the growing mental health needs of the
      aging population. It also addresses moral-ethical dilemmas that will likely
      affect mental health nurses caring for this population.
CI  - Copyright 2010, SLACK Incorporated.
FAU - Loge, Julianne
AU  - Loge J
AD  - Grant MacEwan University, Edmonton, Alberta, Canada. logej@mymail.macewan.ca
FAU - Sorrell, Jeanne M
AU  - Sorrell JM
LA  - eng
PT  - Journal Article
DEP - 20100823
PL  - United States
TA  - J Psychosoc Nurs Ment Health Serv
JT  - Journal of psychosocial nursing and mental health services
JID - 8200911
SB  - IM
MH  - Age Distribution
MH  - Aged
MH  - Dementia/epidemiology/*prevention & control
MH  - *Global Health
MH  - Health Care Reform/ethics/organization & administration
MH  - Health Services Needs and Demand/ethics/*organization & administration
MH  - Health Services for the Aged/ethics/organization & administration
MH  - Humans
MH  - Incidence
MH  - Mental Disorders/epidemiology/*prevention & control
MH  - Psychiatric Nursing/ethics/*organization & administration
EDAT- 2010/08/28 06:00
MHDA- 2010/10/22 06:00
CRDT- 2010/08/28 06:00
PHST- 2010/08/28 06:00 [entrez]
PHST- 2010/08/28 06:00 [pubmed]
PHST- 2010/10/22 06:00 [medline]
AID - 10.3928/02793695-20100730-02 [doi]
PST - ppublish
SO  - J Psychosoc Nurs Ment Health Serv. 2010 Sep;48(9):15-8. doi:
      10.3928/02793695-20100730-02. Epub 2010 Aug 23.


PMID- 20795432
OWN - NLM
STAT- MEDLINE
DCOM- 20100923
LR  - 20141120
IS  - 1020-3397 (Print)
IS  - 1020-3397 (Linking)
VI  - 16
IP  - 4
DP  - 2010 Apr
TI  - Disclosing the truth to terminal cancer patients: a discussion of ethical and
      cultural issues.
PG  - 442-7
AB  - One of the most difficult ethical dilemmas facing health care professionals
      working in oncology is whether, when, how and how much to tell terminal cancer
      patients about their diagnosis and prognosis. The aim of this article is to
      review the trends in this issue worldwide. While a majority of physicians in both
      developed and developing countries tell the truth more often today than in the
      past, the assumption that truth-telling is always beneficial to patients can be
      questioned. The issue of truth-telling is still approached differently in
      different countries and cultures and there is a need for an increased awareness
      of cultural differences to truth-telling among patients from ethnic minorities.
FAU - Kazdaglis, G A
AU  - Kazdaglis GA
AD  - Department of General Surgery, Saint Savvas Oncology Hospital, Athens, Greece.
      kazdaglis@inbox.com
FAU - Arnaoutoglou, C
AU  - Arnaoutoglou C
FAU - Karypidis, D
AU  - Karypidis D
FAU - Memekidou, G
AU  - Memekidou G
FAU - Spanos, G
AU  - Spanos G
FAU - Papadopoulos, O
AU  - Papadopoulos O
LA  - eng
PT  - Journal Article
PL  - Egypt
TA  - East Mediterr Health J
JT  - Eastern Mediterranean health journal = La revue de sante de la Mediterranee
      orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit
JID - 9608387
SB  - IM
MH  - Attitude of Health Personnel/ethnology
MH  - Attitude to Death/ethnology
MH  - Attitude to Health/ethnology
MH  - *Communication
MH  - Cross-Cultural Comparison
MH  - *Cultural Characteristics
MH  - Developed Countries
MH  - Developing Countries
MH  - Family/ethnology
MH  - Global Health
MH  - Humans
MH  - Medical Oncology/ethics
MH  - Neoplasms/diagnosis/*ethnology
MH  - Nurse's Role/psychology
MH  - Physician's Role/psychology
MH  - Principle-Based Ethics
MH  - Professional-Patient Relations/ethics
MH  - Prognosis
MH  - Quality of Life/psychology
MH  - Truth Disclosure/*ethics
EDAT- 2010/08/28 06:00
MHDA- 2010/09/24 06:00
CRDT- 2010/08/28 06:00
PHST- 2010/08/28 06:00 [entrez]
PHST- 2010/08/28 06:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
PST - ppublish
SO  - East Mediterr Health J. 2010 Apr;16(4):442-7.


PMID- 20724884
OWN - NLM
STAT- MEDLINE
DCOM- 20100929
LR  - 20110323
IS  - 1530-0293 (Electronic)
IS  - 0090-3493 (Linking)
VI  - 38
IP  - 9 Suppl
DP  - 2010 Sep
TI  - Ethical controversies at end of life after traumatic brain injury: defining death
      and organ donation.
PG  - S502-9
LID - 10.1097/CCM.0b013e3181ec5354 [doi]
AB  - Death is more than a mere biological occurrence. It has important legal, medical,
      and social ramifications that make it imperative that those who are responsible
      for determination of death be accurate and above suspicion. The medical and legal
      definitions of death have evolved to include consideration of such concepts as
      loss of integration of the whole organism, loss of autonomy, and loss of
      personhood. Development of the concept of brain death coincided with advances in 
      medical technology that facilitated artificial ventilation and organ
      transplantation. More recently, the process of "timed" death with subsequent
      organ donation (controlled donation after cardiac death transplantation) has
      raised controversial questions having to do with the limits of treatments that
      facilitate organ transplant but might hasten death, and the duration of cardiac
      arrest necessary for declaration of death and the commencement of organ
      procurement. In this review, we discuss the background and ethical ramifications 
      of the concepts of brain death, and of controversies involved in controlled
      donation after cardiac death organ transplantation.
FAU - Souter, Michael
AU  - Souter M
AD  - Department of Anesthesiology and Pain Medicine and Neurosurgery, Harborview
      Medical Center, University of Washington, Seattle, WA, USA.
FAU - Van Norman, Gail
AU  - Van Norman G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Crit Care Med
JT  - Critical care medicine
JID - 0355501
SB  - IM
CIN - Crit Care Med. 2011 Mar;39(3):606; author reply 606-7. PMID: 21330871
MH  - *Brain Death
MH  - *Brain Injuries
MH  - Death
MH  - Humans
MH  - Terminal Care/*ethics
MH  - Tissue and Organ Procurement/*ethics
EDAT- 2010/08/28 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/08/21 06:00
PHST- 2010/08/21 06:00 [entrez]
PHST- 2010/08/28 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - 10.1097/CCM.0b013e3181ec5354 [doi]
AID - 00003246-201009001-00012 [pii]
PST - ppublish
SO  - Crit Care Med. 2010 Sep;38(9 Suppl):S502-9. doi: 10.1097/CCM.0b013e3181ec5354.


PMID- 20714010
OWN - NLM
STAT- MEDLINE
DCOM- 20101213
LR  - 20220317
IS  - 1665-2681 (Print)
IS  - 1665-2681 (Linking)
VI  - 9 Suppl
DP  - 2010
TI  - Hepatitis C virus infection in health-care settings: medical and ethical
      implications.
PG  - 132-40
AB  - Hepatitis C is a major public health issue. It infects about 200 million people
      worldwide and is a major cause of chronic liver disease. Its transmission in
      medical facilities is a topic of increased concern, as outbreaks of the disease
      had raised the attention of media and medical authorities. To date, evidence
      suggests that infection from in which a health-care worker is involved is mostly 
      result of bad injecting practices as well as the result of shared medical
      devices. Furthermore, the infection caused by physicians is rare and very few
      well documented cases exist on the literature. Among countries, different
      definitions and legislation exist, in that mode that the responsibility of this
      issue almost is an obligation of individual institutions. Nonetheless, Hepatitis 
      C virus transmission in medical facilities is an important source of new cases,
      and as treatments options are very limited, it's recommendable that institutions 
      as well as governments implement policies to avoid Hepatitis C spread in a almost
      fully preventable setting.
FAU - Bosques-Padilla, Francisco Javier
AU  - Bosques-Padilla FJ
AD  - Facultad de Medicina y Centro Regional para el Estudio de Enfermedades
      Digestivas, Hospital Universitario Dr. Jose Eleuterio Gonzalez, UANL, Monterrey, 
      N.L. Mexico. fbosques58@hotmail.com
FAU - Vazquez-Elizondo, Genaro
AU  - Vazquez-Elizondo G
FAU - Villasenor-Todd, Ana
AU  - Villasenor-Todd A
FAU - Garza-Gonzalez, Elvira
AU  - Garza-Gonzalez E
FAU - Gonzalez-Gonzalez, Jose Alberto
AU  - Gonzalez-Gonzalez JA
FAU - Maldonado-Garza, Hector Jesus
AU  - Maldonado-Garza HJ
LA  - eng
PT  - Journal Article
PL  - Mexico
TA  - Ann Hepatol
JT  - Annals of hepatology
JID - 101155885
SB  - IM
MH  - Cross Infection/epidemiology/prevention & control/*transmission/virology
MH  - Health Policy
MH  - Hepatitis C/epidemiology/prevention & control/*transmission
MH  - Humans
MH  - *Infection Control/legislation & jurisprudence/methods
MH  - *Infectious Disease Transmission, Patient-to-Professional/ethics/legislation &
      jurisprudence
MH  - Occupational Diseases/epidemiology/prevention & control/*virology
MH  - *Occupational Exposure
MH  - Occupational Health/legislation & jurisprudence
MH  - Risk Assessment
MH  - Risk Factors
EDAT- 2010/08/28 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/18 06:00
PHST- 2010/08/18 06:00 [entrez]
PHST- 2010/08/28 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 916042 [pii]
PST - ppublish
SO  - Ann Hepatol. 2010;9 Suppl:132-40.


PMID- 20740324
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20211020
IS  - 1525-1497 (Electronic)
IS  - 0884-8734 (Linking)
VI  - 25
IP  - 12
DP  - 2010 Dec
TI  - Medical professionalism: conflicting values for tomorrow's doctors.
PG  - 1330-6
LID - 10.1007/s11606-010-1485-8 [doi]
AB  - BACKGROUND: New values and practices associated with medical professionalism have
      created an increased interest in the concept. In the United Kingdom, it is a
      current concern in medical education and in the development of doctor appraisal
      and revalidation. OBJECTIVE: To investigate how final year medical students
      experience and interpret new values of professionalism as they emerge in relation
      to confronting dying patients and as they potentially conflict with older values 
      that emerge through hidden dimensions of the curriculum. METHODS: Qualitative
      study using interpretative discourse analysis of anonymized student reflective
      portfolios. One hundred twenty-three final year undergraduate medical students
      (64 male and 59 female) from the University of Cambridge School of Clinical
      Medicine supplied 116 portfolios from general practice and 118 from hospital
      settings about patients receiving palliative or end of life care. RESULTS:
      Professional values were prevalent in all the portfolios. Students emphasised
      patient-centered, holistic care, synonymous with a more contemporary idea of
      professionalism, in conjunction with values associated with the 'old' model of
      professionalism that had not be directly taught to them. Integrating 'new'
      professional values was at times problematic. Three main areas of potential
      conflict were identified: ethical considerations, doctor-patient interaction and 
      subjective boundaries. Students explicitly and implicitly discussed several
      tensions and described strategies to resolve them. CONCLUSIONS: The conflicts
      outlined arise from the mix of values associated with different models of
      professionalism. Analysis indicates that 'new' models are not simply replacing
      existing elements. Whilst this analysis is of accounts from students within one
      UK medical school, the experience of conflict between different notions of
      professionalism and the three broad domains in which this conflict arises are
      relevant in other areas of medicine and in different national contexts.
FAU - Borgstrom, Erica
AU  - Borgstrom E
AD  - General Practice and Primary Care Research Unit, University of Cambridge,
      Cambridge, UK. eb442@medschl.cam.ac.uk
FAU - Cohn, Simon
AU  - Cohn S
FAU - Barclay, Stephen
AU  - Barclay S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100826
PL  - United States
TA  - J Gen Intern Med
JT  - Journal of general internal medicine
JID - 8605834
SB  - IM
MH  - Clinical Competence/*standards
MH  - Female
MH  - Forecasting
MH  - Humans
MH  - Male
MH  - Physician-Patient Relations/*ethics
MH  - Physicians/*ethics/*standards/trends
MH  - *Social Values
PMC - PMC2988149
EDAT- 2010/08/27 06:00
MHDA- 2011/10/01 06:00
CRDT- 2010/08/27 06:00
PHST- 2010/02/15 00:00 [received]
PHST- 2010/08/04 00:00 [accepted]
PHST- 2010/05/12 00:00 [revised]
PHST- 2010/08/27 06:00 [entrez]
PHST- 2010/08/27 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - 10.1007/s11606-010-1485-8 [doi]
PST - ppublish
SO  - J Gen Intern Med. 2010 Dec;25(12):1330-6. doi: 10.1007/s11606-010-1485-8. Epub
      2010 Aug 26.


PMID- 20739760
OWN - NLM
STAT- MEDLINE
DCOM- 20101101
LR  - 20151221
IS  - 0972-2823 (Electronic)
IS  - 0022-3859 (Linking)
VI  - 56
IP  - 3
DP  - 2010 Jul-Sep
TI  - Apolipoprotein E gene polymorphism and total serum cholesterol level in Iranian
      population.
PG  - 173-5
LID - 10.4103/0022-3859.68629 [doi]
AB  - BACKGROUND: Apolipoprotein E (APOE) is known as a major regulator of blood lipid 
      levels in humans. A number of APOE gene allelic variants have been reported
      including E2, E3 and E4. Recent studies suggested a role for APOE in obesity and 
      increased Body Mass Index (BMI) and plasma lipid levels in obese children. AIM:
      The aim of this study was to examine the association between APOE genetic
      variants and the BMI and lipid profile in an Iranian cohort. SETTING AND DESIGN: 
      Samples were obtained from subjects who participated in a study based on the
      WHO-designed MONICA (multinational monitoring of trends and determinants in
      cardiovascular disease) study for coronary artery disease risk assessment in Zone
      17 of Tehran. The study was approved by the local ethical committee. Informed
      consent was obtained from all subjects included in this study. MATERIALS AND
      METHODS: Subjects (n=320) were recruited. The level of triglyceride (TG) and
      total serum cholesterol was tested for all subjects in this study. Genotyping for
      APOE was carried using polymerase chain reaction-Restriction fragment length
      polymorphism (PCR-RFLP)technique. STATISTICAL ANALYSIS: Levels of significance
      were determined using contingency tables by either Chi-square or Fisher exact
      analysis using the STATA (v8) software. The analysis of regression and
      significance of differences for level of cholesterol and TG was established by
      one-way analysis of variance followed by Dunnett post hoc multiple comparison
      tests using SPSS software Version 11.5. RESULTS: The frequency of allele E2 was
      significantly higher in patients with total serum cholesterol level <200 mg/dl (P
      0.01 OR 2.1 95% CI 1.1-4.2). CONCLUSION: The association found in this study
      between allele E2 and lower total cholesterol level had been reported in previous
      studies. We have also observed that the frequency of genotype E2/E3 and E2/E4 was
      significantly higher in patients with normal total serum cholesterol level
      compared to patients with abnormal cholesterol (P=0.003 OR 2.4 95% CI; 1.3-4.6). 
      Our data needs to be repeated in a larger population with more information for
      serum LDL and HDL levels and their subgroups.
FAU - Bazzaz, J T
AU  - Bazzaz JT
AD  - Endocrinology and Metabolism Research Centre, Tehran University of Medical
      Sciences, Tehran, Iran.
FAU - Nazari, M
AU  - Nazari M
FAU - Nazem, H
AU  - Nazem H
FAU - Amiri, P
AU  - Amiri P
FAU - Fakhrzadeh, H
AU  - Fakhrzadeh H
FAU - Heshmat, R
AU  - Heshmat R
FAU - Abbaszadeh, S
AU  - Abbaszadeh S
FAU - Amoli, M M
AU  - Amoli MM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - India
TA  - J Postgrad Med
JT  - Journal of postgraduate medicine
JID - 2985196R
RN  - 0 (Apolipoproteins E)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Apolipoproteins E/*genetics
MH  - Arabs/*genetics
MH  - Body Mass Index
MH  - Cholesterol/*blood
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Hyperlipidemias/genetics
MH  - Iran
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Restriction Fragment Length/*genetics
MH  - Triglycerides/*blood
EDAT- 2010/08/27 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/08/27 06:00
PHST- 2010/08/27 06:00 [entrez]
PHST- 2010/08/27 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - jpgm_2010_56_3_173_68629 [pii]
AID - 10.4103/0022-3859.68629 [doi]
PST - ppublish
SO  - J Postgrad Med. 2010 Jul-Sep;56(3):173-5. doi: 10.4103/0022-3859.68629.


PMID- 20739708
OWN - NLM
STAT- MEDLINE
DCOM- 20110225
LR  - 20211203
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 11
DP  - 2010 Nov
TI  - The role of doctors' religious faith and ethnicity in taking ethically
      controversial decisions during end-of-life care.
PG  - 677-82
LID - 10.1136/jme.2010.036194 [doi]
AB  - BACKGROUND AND AIMS: The prevalence of religious faith among doctors and its
      relationship with decision-making in end-of-life care is not well documented. The
      impact of ethnic differences on this is also poorly understood. This study
      compares ethnicity and religious faith in the medical and general UK populations,
      and reports on their associations with ethically controversial decisions taken
      when providing care to dying patients. METHOD: A postal survey of 3733 UK medical
      practitioners, of whom 2923 reported on the care of their last patient who died. 
      FINDINGS: Specialists in care of the elderly were somewhat more likely to be
      Hindu or Muslim than other doctors; palliative care specialists were somewhat
      more likely to be Christian, religious and 'white' than others. Ethnicity was
      largely unrelated to rates of reporting ethically controversial decisions.
      Independently of speciality, doctors who described themselves as non-religious
      were more likely than others to report having given continuous deep sedation
      until death, having taken decisions they expected or partly intended to end life,
      and to have discussed these decisions with patients judged to have the capacity
      to participate in discussions. Speciality was independently related to wide
      variations in the reporting of decisions taken with some intent to end life, with
      doctors in 'other hospital' specialities being almost 10 times as likely to
      report this when compared with palliative medicine specialists, regardless of
      religious faith. CONCLUSIONS: Greater acknowledgement of the relationship of
      doctors' values with clinical decision-making is advocated.
FAU - Seale, Clive
AU  - Seale C
AD  - Centre for Health Sciences, Barts and the London School of Medicine and
      Dentistry, Queen Mary University of London, UK. c.seale@qmul.ac.uk
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100825
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
CIN - J Med Ethics. 2011 Jan;37(1):61. PMID: 20952492
CIN - J Med Ethics. 2011 Jan;37(1):61. PMID: 21112932
MH  - Asians/ethnology
MH  - Attitude of Health Personnel/*ethnology
MH  - *Decision Making/ethics
MH  - Humans
MH  - Logistic Models
MH  - Multivariate Analysis
MH  - Physicians/*psychology
MH  - *Religion
MH  - Religion and Medicine
MH  - Surveys and Questionnaires
MH  - Terminal Care/*ethics/*psychology
MH  - United Kingdom
MH  - Whites/ethnology
EDAT- 2010/08/27 06:00
MHDA- 2011/02/26 06:00
CRDT- 2010/08/27 06:00
PHST- 2010/08/27 06:00 [entrez]
PHST- 2010/08/27 06:00 [pubmed]
PHST- 2011/02/26 06:00 [medline]
AID - jme.2010.036194 [pii]
AID - 10.1136/jme.2010.036194 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Nov;36(11):677-82. doi: 10.1136/jme.2010.036194. Epub 2010 Aug
      25.


PMID- 20738887
OWN - NLM
STAT- MEDLINE
DCOM- 20101007
LR  - 20211020
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 11
DP  - 2010 Aug 26
TI  - Ethics, economics and the regulation and adoption of new medical devices: case
      studies in pelvic floor surgery.
PG  - 14
LID - 10.1186/1472-6939-11-14 [doi]
AB  - BACKGROUND: Concern has been growing in the academic literature and popular media
      about the licensing, introduction and adoption of surgical devices before full
      effectiveness and safety evidence is available to inform clinical practice. Our
      research will seek empirical survey evidence about the roles, responsibilities,
      and information and policy needs of the key stakeholders in the introduction into
      clinical practice of new surgical devices for pelvic floor surgery, in terms of
      the underlying ethical principals involved in the economic decision-making
      process, using the example of pelvic floor procedures. METHODS/DESIGN: Our study 
      involves three linked case studies using, as examples, selected pelvic floor
      surgery devices representing Health Canada device safety risk classes: low,
      medium and high risk. Data collection will focus on stakeholder roles and
      responsibilities, information and policy needs, and perceptions of those of other
      key stakeholders, in seeking and using evidence about new surgical devices when
      licensing and adopting them into practice. For each class of device, interviews
      will be used to seek the opinions of stakeholders. The following stakeholders and
      ethical and economic principles provide the theoretical framework for the study: 
      Stakeholders--federal regulatory body, device manufacturers, clinicians,
      patients, health care institutions, provincial health departments, and
      professional societies. Clinical settings in two centres (in different provinces)
      will be included. Ethics--beneficence, non-maleficence, autonomy, justice.
      Economics--scarcity of resources, choices, opportunity costs.For each class of
      device, responses will be analysed to compare and contrast between stakeholders. 
      Applied ethics and economic theory, analysis and critical interpretation will be 
      used to further illuminate the case study material. DISCUSSION: The significance 
      of our research in this new area of ethics will lie in providing recommendations 
      for regulatory bodies, device manufacturers, clinicians, health care
      institutions, policy makers and professional societies, to ensure surgical
      patients receive sufficient information before providing consent for pelvic floor
      surgery. In addition, we shall provide a wealth of information for future study
      in other areas of surgery and clinical management, and provide suggestions for
      changes to health policy.
FAU - Ross, Sue
AU  - Ross S
AD  - Department of Obstetrics and Gynaecology, University of Calgary, Calgary, Canada.
      sue.ross@albertahealthservices.ca
FAU - Weijer, Charles
AU  - Weijer C
FAU - Gafni, Amiram
AU  - Gafni A
FAU - Ducey, Ariel
AU  - Ducey A
FAU - Thompson, Carmen
AU  - Thompson C
FAU - Lafreniere, Rene
AU  - Lafreniere R
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100826
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Beneficence
MH  - Canada
MH  - Conflict of Interest
MH  - Decision Making/ethics
MH  - Device Approval/legislation & jurisprudence/standards
MH  - *Economics, Hospital
MH  - Equipment and Supplies/economics/ethics
MH  - Female
MH  - Gynecologic Surgical Procedures/*instrumentation
MH  - Humans
MH  - Legislation, Medical/trends
MH  - Pelvic Floor/*surgery
MH  - Personal Autonomy
MH  - *Principle-Based Ethics
MH  - Social Justice
MH  - Surgical Instruments/*economics/*ethics/standards
MH  - Urologic Surgical Procedures/*instrumentation
PMC - PMC2936433
EDAT- 2010/08/27 06:00
MHDA- 2010/10/12 06:00
CRDT- 2010/08/27 06:00
PHST- 2010/07/20 00:00 [received]
PHST- 2010/08/26 00:00 [accepted]
PHST- 2010/08/27 06:00 [entrez]
PHST- 2010/08/27 06:00 [pubmed]
PHST- 2010/10/12 06:00 [medline]
AID - 1472-6939-11-14 [pii]
AID - 10.1186/1472-6939-11-14 [doi]
PST - epublish
SO  - BMC Med Ethics. 2010 Aug 26;11:14. doi: 10.1186/1472-6939-11-14.


PMID- 20738879
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1749-7922 (Electronic)
IS  - 1749-7922 (Linking)
VI  - 5
DP  - 2010 Aug 25
TI  - Necessity of immediate cardiopulmonary resuscitation in trauma emergency.
PG  - 25
LID - 10.1186/1749-7922-5-25 [doi]
AB  - The ability to respond quickly and effectively to a cardiac arrest situation
      rests on nurses being competent in the emergency life-saving procedure of
      cardiopulmonary resuscitation. The objective of the current study was to evaluate
      the types of trauma and survival of patients that require immediate
      cardiopulmonary resuscitation in trauma emergencies. A total of 13301 patients
      treated as accident victims between July 2004 and December 2006 were evaluated in
      a prospective study. Patients requiring immediate cardiopulmonary resuscitation
      at admission were identified. The type of injury and the survival of these
      patients were evaluated.Of the 65 patients included in the study, 30% had
      suffered from gunshot wounds, 19% had been run over, 18% had been involved in car
      crashes, 13% in motor cycle accidents, 9% stabbings, 1% by cycle accidents and
      10% other types of accidents including burns, hangings and falls. In only 12 of
      these patients, immediate resuscitation was successful and procedure such as
      chest drainage, exploratory laparotomy and interventions in the surgical center
      were performed. However all patients evolved to death; eight within 24 hours, two
      between 24 and 48 hours and the other 2 after 48 hours.Immediate cardiopulmonary 
      resuscitation after accidents is a sign of high mortality requiring further
      studies to review indication and the ethical aspects involved.
FAU - Luciano, Baitello Andre
AU  - Luciano BA
AD  - Department of Cardiology and Cardiovascular Surgery in Medicine School in Sao
      Jose do Rio Preto (FAMERP) and CNPq (National Council for Research and
      Development)-Brazil. godoyjmp@riopreto.com.br.
FAU - Marcela, Gonzales Ferreira
AU  - Marcela GF
FAU - Cesar, Espada Paulo
AU  - Cesar EP
FAU - de Godoy, Jose Maria Pereira
AU  - de Godoy JM
LA  - eng
PT  - Journal Article
DEP - 20100825
PL  - England
TA  - World J Emerg Surg
JT  - World journal of emergency surgery : WJES
JID - 101266603
PMC - PMC2936878
EDAT- 2010/08/27 06:00
MHDA- 2010/08/27 06:01
CRDT- 2010/08/27 06:00
PHST- 2010/06/05 00:00 [received]
PHST- 2010/08/25 00:00 [accepted]
PHST- 2010/08/27 06:00 [entrez]
PHST- 2010/08/27 06:00 [pubmed]
PHST- 2010/08/27 06:01 [medline]
AID - 1749-7922-5-25 [pii]
AID - 10.1186/1749-7922-5-25 [doi]
PST - epublish
SO  - World J Emerg Surg. 2010 Aug 25;5:25. doi: 10.1186/1749-7922-5-25.


PMID- 20738008
OWN - NLM
STAT- MEDLINE
DCOM- 20100915
LR  - 20211020
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 678
DP  - 2010
TI  - Imaging as a means of studying chemotherapy-related cognitive impairment.
PG  - 70-6
AB  - The chemotherapy-related cognitive impairment (chemo fog/chemo brain) that is
      reported by many cancer patients is supported to varying degrees primarily by
      evidence from prospective and retrospective clinical studies. However, the
      inherent difficulty in conducting such trials (including ethical issues of
      placebo-controlled designs), the fact that the cognitive impairment is
      characteristically subtle and that the patients might be able to compensate for
      their deficits during testing, gives rise to questions about the degree and the
      extent of the problem-and indeed even if there is a problem. Neuroimaging
      techniques might offer additional insight. This chapter is a succinct summary of 
      a more expanded review of the relatively few such studies.
FAU - Raffa, Robert B
AU  - Raffa RB
AD  - Department of Pharmaceutical Sciences, Temple University School of Pharmacy,
      Philadelphia, Pennsylvania 19140, USA. robert.raffa@temple.edu
LA  - eng
GR  - R01 CA129092/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Antineoplastic Agents/*adverse effects
MH  - Cognition Disorders/*chemically induced/diagnosis/physiopathology
MH  - Diagnostic Imaging/*methods
MH  - *Drug-Related Side Effects and Adverse Reactions
MH  - Electrophysiological Phenomena/drug effects
MH  - Humans
RF  - 33
EDAT- 2010/08/27 06:00
MHDA- 2010/09/17 06:00
CRDT- 2010/08/27 06:00
PHST- 2010/08/27 06:00 [entrez]
PHST- 2010/08/27 06:00 [pubmed]
PHST- 2010/09/17 06:00 [medline]
AID - 10.1007/978-1-4419-6306-2_10 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2010;678:70-6. doi: 10.1007/978-1-4419-6306-2_10.


PMID- 20737807
OWN - NLM
STAT- MEDLINE
DCOM- 20100929
LR  - 20211020
IS  - 0008-4263 (Print)
IS  - 0008-4263 (Linking)
VI  - 101
IP  - 3
DP  - 2010 May-Jun
TI  - [Expensive drugs and intergenerational justice].
PG  - 193-5
AB  - Among all categories of health expenditure in Canada, spending on drugs is the
      fastest growing. The factors at play in the increase in expenditure on drugs are 
      essentially those related to the volume of use and the arrival of new drugs on
      the market. Some of these new drugs are very expensive. In fact, the costs of
      certain drugs threaten the continued existence of the Quebec Prescription Drug
      Insurance Plan. In Quebec, the Conseil du medicament (Drug Board) is responsible 
      for recommending drugs to the Ministry of Health and Social Services to be put on
      the formulary of drugs covered by the public plan. In spite of pressure by
      various stakeholders, we believe that the rationing of drugs that are too
      expensive can achieve political legitimacy if it is based on a transparent
      justification that includes not only evidence-based criteria, but also ethical
      principles and values. For egalitarians, fairness in the supply of health care
      should be accomplished as a function of health care needs. But this concept of
      justice should also be extended to future generations. The balance of current and
      future needs should be achieved by determining what would be "reasonable access" 
      through public consultations among experts and citizens.
FAU - Hughes, David
AU  - Hughes D
AD  - Programme complementaire en Analyse et evaluation des interventions en sante,
      Universite de Montreal, Montreal, QC. david.hughes@umontreal.ca
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Les medicaments onereux et la justice intergenerationnelle.
PL  - Switzerland
TA  - Can J Public Health
JT  - Canadian journal of public health = Revue canadienne de sante publique
JID - 0372714
SB  - IM
MH  - Canada
MH  - *Drug Costs
MH  - Formularies as Topic
MH  - Health Care Rationing/ethics
MH  - Health Services Accessibility/ethics
MH  - Humans
MH  - *Insurance, Pharmaceutical Services
MH  - Quebec
PMC - PMC6973836
EDAT- 2010/08/27 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/08/27 06:00
PHST- 2010/08/27 06:00 [entrez]
PHST- 2010/08/27 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
PST - ppublish
SO  - Can J Public Health. 2010 May-Jun;101(3):193-5.


PMID- 20737699
OWN - NLM
STAT- MEDLINE
DCOM- 20101123
LR  - 20100825
IS  - 0201-7563 (Print)
IS  - 0201-7563 (Linking)
IP  - 3
DP  - 2010 May-Jun
TI  - [Role of an anesthesiologist-resuscitation specialist in organ donation for
      transplantation].
PG  - 4-8
AB  - There is an annual reduction in the number of donors worldwide. An
      anesthesiologist-resuscitation specialist is a key figure in the whole system of 
      organ donation. The so-called transplantation, i.e., the organization of the
      whole process of interaction between a healthy care facility, a local organ
      donation center, and ancillary laboratory and diagnostic services is one of
      his/her primary roles in organ donation. The organizational, legal, and ethic
      issues of organ donation for transplantation are discussed from the viewpoint of 
      an anesthesiologist-resuscitation specialist. There is a parallel between the
      treatment of a patient with multiple organ dysfunction and the management of a
      donor with brain death.
FAU - Iaroshetskii, A I
AU  - Iaroshetskii AI
FAU - Protsenko, D N
AU  - Protsenko DN
FAU - Gel'fand, B R
AU  - Gel'fand BR
LA  - rus
PT  - English Abstract
PT  - Journal Article
PL  - Russia (Federation)
TA  - Anesteziol Reanimatol
JT  - Anesteziologiia i reanimatologiia
JID - 7705399
RN  - 0 (Interleukin-6)
SB  - IM
MH  - Anesthesiology/ethics/*methods
MH  - Brain Death/blood/immunology
MH  - Cadaver
MH  - Critical Care/ethics/methods
MH  - Ethics, Clinical
MH  - Government Regulation
MH  - Humans
MH  - Interleukin-6/blood
MH  - Organ Transplantation/ethics/legislation & jurisprudence/*methods
MH  - Russia
MH  - Tissue Donors/ethics/legislation & jurisprudence/*supply & distribution
MH  - Tissue and Organ Procurement/ethics/legislation &
      jurisprudence/methods/*organization & administration
EDAT- 2010/08/26 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/26 06:00
PHST- 2010/08/26 06:00 [entrez]
PHST- 2010/08/26 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - Anesteziol Reanimatol. 2010 May-Jun;(3):4-8.


PMID- 20736974
OWN - NLM
STAT- MEDLINE
DCOM- 20110228
LR  - 20211020
IS  - 1476-5438 (Electronic)
IS  - 1018-4813 (Linking)
VI  - 18
IP  - 12
DP  - 2010 Dec
TI  - Statement of the ESHG on direct-to-consumer genetic testing for health-related
      purposes.
PG  - 1271-3
LID - 10.1038/ejhg.2010.129 [doi]
AB  - Many private companies offer direct-to-consumer (DTC) genetic testing services.
      Some tests may detect severe and highly penetrant monogenic disorders, while
      other tests are for genetic variants found associated with increased
      susceptibility for common and complex diseases in large-scale population studies.
      Through its Public and Professional Policy committee followed by member and
      expert consultation, the European Society of Human Genetics has developed the
      following policy on advertising and provision of predictive genetic tests by such
      DTC companies: (1) clinical utility of a genetic test shall be an essential
      criterion for deciding to offer this test to a person or a group of persons; (2) 
      laboratories providing genetic tests should comply with accepted quality
      standards, including those regarding laboratory personnel qualifications; (3)
      information about the purpose and appropriateness of testing should be given
      before the test is done; (4) genetic counselling appropriate to the type of test 
      and disease should be offered; and for some tests psychosocial evaluation and
      follow-up should be available; (5) privacy and confidentiality of sensitive
      genetic information should be secured and the data safely guarded; (6) special
      measures should be taken to avoid inappropriate testing of minors and other
      legally incapacitated persons; (7) all claims regarding genetic tests should be
      transparent; advertisement should be unbiased and marketing of genetic tests
      should be fair; (8) in biomedical research, health care and marketing, respect
      should be given to relevant ethical principles, as well as international treaties
      and recommendations regarding genetic testing; and (9) nationally approved
      guidelines considering all the above-mentioned aspects should be made and
      followed.
CN  - European Society of Human Genetics
LA  - eng
PT  - Journal Article
DEP - 20100825
PL  - England
TA  - Eur J Hum Genet
JT  - European journal of human genetics : EJHG
JID - 9302235
SB  - IM
MH  - Advertising/standards
MH  - *Delivery of Health Care
MH  - Europe
MH  - Genetic Counseling
MH  - Genetic Privacy
MH  - Genetic Testing/economics/ethics/*methods/*standards
MH  - *Genetics, Medical
MH  - Guidelines as Topic
MH  - *Health Policy
MH  - Humans
MH  - Informed Consent
MH  - Minors
MH  - *Societies, Medical
PMC - PMC3002858
EDAT- 2010/08/26 06:00
MHDA- 2011/03/01 06:00
CRDT- 2010/08/26 06:00
PHST- 2010/08/26 06:00 [entrez]
PHST- 2010/08/26 06:00 [pubmed]
PHST- 2011/03/01 06:00 [medline]
AID - ejhg2010129 [pii]
AID - 10.1038/ejhg.2010.129 [doi]
PST - ppublish
SO  - Eur J Hum Genet. 2010 Dec;18(12):1271-3. doi: 10.1038/ejhg.2010.129. Epub 2010
      Aug 25.


PMID- 20736755
OWN - NLM
STAT- MEDLINE
DCOM- 20121022
LR  - 20211203
IS  - 1550-5057 (Electronic)
IS  - 0160-6379 (Linking)
VI  - 33
IP  - 4
DP  - 2010 Oct-Dec
TI  - Lessons from the field: Using photovoice with an ethnically diverse population in
      a HOPE VI evaluation.
PG  - 275-84
LID - 10.1097/FCH.0b013e3181f3b2a0 [doi]
AB  - An interdisciplinary research team evaluated a public housing revitalization
      project in northwest Washington State to assess the effects of relocation on
      residents and provide recommendations on assets in the new community. Researchers
      used photovoice as one method to gather data, asking participants to take
      photographs of their neighborhood and discuss the images with interviewers. This 
      article addresses the challenges of using photovoice in a community that included
      immigrants from Cambodia, Vietnam, and Russia. The practical, ethical, and social
      challenges of using photovoice in ethnically diverse populations and implications
      for practice are discussed.
FAU - Stevens, Christine A
AU  - Stevens CA
AD  - University of Washington Tacoma, Tacoma, WA 98402, USA. cstevens@u.washington.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Fam Community Health
JT  - Family & community health
JID - 7809641
SB  - IM
MH  - *Emigrants and Immigrants
MH  - *Ethnicity
MH  - Humans
MH  - *Photography
MH  - Population Dynamics
MH  - *Public Housing
MH  - Washington
EDAT- 2010/08/26 06:00
MHDA- 2012/10/23 06:00
CRDT- 2010/08/26 06:00
PHST- 2010/08/26 06:00 [entrez]
PHST- 2010/08/26 06:00 [pubmed]
PHST- 2012/10/23 06:00 [medline]
AID - 10.1097/FCH.0b013e3181f3b2a0 [doi]
AID - 00003727-201010000-00005 [pii]
PST - ppublish
SO  - Fam Community Health. 2010 Oct-Dec;33(4):275-84. doi:
      10.1097/FCH.0b013e3181f3b2a0.


PMID- 20736687
OWN - NLM
STAT- MEDLINE
DCOM- 20110325
LR  - 20100825
IS  - 1473-5571 (Electronic)
IS  - 0269-9370 (Linking)
VI  - 24
IP  - 14
DP  - 2010 Sep 10
TI  - Ethics and the standards of prevention in HIV prevention trials.
PG  - 2298-9; author reply 2299-300
LID - 10.1097/QAD.0b013e32833d4364 [doi]
FAU - Sugarman, Jeremy
AU  - Sugarman J
FAU - Grace, William C
AU  - Grace WC
LA  - eng
GR  - U01AI068619/AI/NIAID NIH HHS/United States
PT  - Comment
PT  - Letter
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - AIDS
JT  - AIDS (London, England)
JID - 8710219
SB  - IM
CON - AIDS. 2010 Mar 13;24(5):621-35. PMID: 20179575
MH  - Clinical Trials as Topic/*ethics
MH  - HIV Infections/*prevention & control
MH  - Humans
MH  - Primary Prevention/*ethics/standards
EDAT- 2010/08/26 06:00
MHDA- 2011/03/26 06:00
CRDT- 2010/08/26 06:00
PHST- 2010/08/26 06:00 [entrez]
PHST- 2010/08/26 06:00 [pubmed]
PHST- 2011/03/26 06:00 [medline]
AID - 10.1097/QAD.0b013e32833d4364 [doi]
AID - 00002030-201009100-00024 [pii]
PST - ppublish
SO  - AIDS. 2010 Sep 10;24(14):2298-9; author reply 2299-300. doi:
      10.1097/QAD.0b013e32833d4364.


PMID- 20736662
OWN - NLM
STAT- MEDLINE
DCOM- 20100928
LR  - 20100825
IS  - 1938-808X (Electronic)
IS  - 1040-2446 (Linking)
VI  - 85
IP  - 9
DP  - 2010 Sep
TI  - An ethical imperative to use reprocessed medical equipment.
PG  - 1397; author reply 1397
LID - 10.1097/ACM.0b013e3181eaa578 [doi]
FAU - Macpherson, Cheryl
AU  - Macpherson C
LA  - eng
PT  - Comment
PT  - Letter
PL  - United States
TA  - Acad Med
JT  - Academic medicine : journal of the Association of American Medical Colleges
JID - 8904605
SB  - IM
CON - Acad Med. 2010 Mar;85(3):398-400. PMID: 20182109
MH  - Academic Medical Centers
MH  - *Conservation of Natural Resources
MH  - Delivery of Health Care/*ethics
MH  - *Equipment Reuse
MH  - Informed Consent
MH  - United States
EDAT- 2010/08/26 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/08/26 06:00
PHST- 2010/08/26 06:00 [entrez]
PHST- 2010/08/26 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - 10.1097/ACM.0b013e3181eaa578 [doi]
AID - 00001888-201009000-00002 [pii]
PST - ppublish
SO  - Acad Med. 2010 Sep;85(9):1397; author reply 1397. doi:
      10.1097/ACM.0b013e3181eaa578.


PMID- 20736398
OWN - NLM
STAT- MEDLINE
DCOM- 20101115
LR  - 20181201
IS  - 1468-2044 (Electronic)
IS  - 0003-9888 (Linking)
VI  - 95
IP  - 10
DP  - 2010 Oct
TI  - Survey of the use of therapeutic hypothermia post cardiac arrest.
PG  - 796-9
LID - 10.1136/adc.2009.176735 [doi]
AB  - OBJECTIVES: Therapeutic hypothermia improves neurological outcome in adults after
      ventricular fibrillation cardiac arrest and neonates with hypoxic ischaemic
      encephalopathy. There is currently no clinical research to support its use in the
      paediatric population. This survey aims to ascertain current practice in the UK, 
      and attitudes and opinions to guide the feasibility of a UK multicentre,
      randomised, controlled trial of therapeutic hypothermia after cardiac arrest in
      children (The Cold-PACK Post Arrest Cooling in Kids study). METHODS: Anonymous
      survey of UK paediatric intensive care consultants (n=149). RESULTS: A total of
      113 (76%) of 149 surveys were returned; 65% responded that they do not know if
      therapeutic hypothermia improves survival after cardiac arrest. Despite this, 48%
      'always' or 'often' use therapeutic hypothermia after return of spontaneous
      circulation following cardiac arrest in children. Among those who never use
      therapeutic hypothermia (33%) the commonest explanation given was 'not enough
      research evidence' (91%). With respect to the dose of therapeutic hypothermia the
      median duration of cooling used is 24-48 h (range 4-72 h) and median target
      temperature 34 degrees C to 35 degrees C (range 32 degrees C to 37 degrees C);
      68% target a temperature range higher than that applied in the published adult
      and neonatal studies (33+/-1 degrees C). There was strong support for a trial of 
      therapeutic hypothermia being ethical (89%) and using deferred consent (85%).
      CONCLUSIONS: Wide variation in UK practice in the use of therapeutic hypothermia 
      and a state of clinical equipoise is demonstrated by this survey, which shows
      important support for UK multicentre collaboration in a future trial of
      therapeutic hypothermia after cardiac arrest.
FAU - Scholefield, Barnaby R
AU  - Scholefield BR
AD  - Paediatric Intensive Care Unit, Birmingham Children's Hospital, Steelhouse Lane, 
      Birmingham B4 6NH, UK. barnaby.scholefield@bch.nhs.uk
FAU - Duncan, Heather P
AU  - Duncan HP
FAU - Morris, Kevin P
AU  - Morris KP
LA  - eng
PT  - Journal Article
DEP - 20100824
PL  - England
TA  - Arch Dis Child
JT  - Archives of disease in childhood
JID - 0372434
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Body Temperature
MH  - Child
MH  - Critical Care/methods
MH  - Health Care Surveys
MH  - Heart Arrest/*therapy
MH  - Humans
MH  - Hypothermia, Induced/methods/*statistics & numerical data
MH  - Patient Selection
MH  - Professional Practice/statistics & numerical data
MH  - Randomized Controlled Trials as Topic
MH  - Time Factors
MH  - United Kingdom
EDAT- 2010/08/26 06:00
MHDA- 2010/11/16 06:00
CRDT- 2010/08/26 06:00
PHST- 2010/08/26 06:00 [entrez]
PHST- 2010/08/26 06:00 [pubmed]
PHST- 2010/11/16 06:00 [medline]
AID - adc.2009.176735 [pii]
AID - 10.1136/adc.2009.176735 [doi]
PST - ppublish
SO  - Arch Dis Child. 2010 Oct;95(10):796-9. doi: 10.1136/adc.2009.176735. Epub 2010
      Aug 24.


PMID- 20736299
OWN - NLM
STAT- MEDLINE
DCOM- 20110111
LR  - 20211020
IS  - 1549-490X (Electronic)
IS  - 1083-7159 (Linking)
VI  - 15
IP  - 9
DP  - 2010
TI  - Smoking and ethics: what are the duties of oncologists?
PG  - 987-93
LID - 10.1634/theoncologist.2010-0034 [doi]
AB  - The World Health Organization's 2009 report on the world's tobacco epidemic
      predicts that, unchecked, tobacco use will kill a billion people in this century.
      Oncologists have a special professional role to play in combating this epidemic. 
      Based on two views of professionalism, this editorial argues that oncologists
      have three duties. First, oncologists should be role models. They should not
      smoke themselves and urge their colleagues to do the same. Second, oncologists
      must strongly advise their own patients to stop smoking and advocate for
      tobacco-free environments in their patients' communities. Third, oncologists have
      duties to their international colleagues. They should share their experience in
      combating tobacco use with them, encourage and assist them to quit smoking, and
      help them advocate for smoke-free environments. Further, oncologists should work 
      to ratify the Framework Convention on Tobacco Control in their own country.
FAU - Pentz, Rebecca D
AU  - Pentz RD
AD  - Emory University School of Medicine, Atlanta, Georgia 30322, USA.
      rpentz@emory.edu
FAU - Berg, Carla J
AU  - Berg CJ
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100824
PL  - England
TA  - Oncologist
JT  - The oncologist
JID - 9607837
SB  - IM
MH  - Humans
MH  - *Medical Oncology
MH  - *Physician's Role
MH  - Smoking Cessation
MH  - *Smoking Prevention
PMC - PMC3228038
EDAT- 2010/08/26 06:00
MHDA- 2011/01/12 06:00
CRDT- 2010/08/26 06:00
PHST- 2010/08/26 06:00 [entrez]
PHST- 2010/08/26 06:00 [pubmed]
PHST- 2011/01/12 06:00 [medline]
AID - theoncologist.2010-0034 [pii]
AID - 10.1634/theoncologist.2010-0034 [doi]
PST - ppublish
SO  - Oncologist. 2010;15(9):987-93. doi: 10.1634/theoncologist.2010-0034. Epub 2010
      Aug 24.


PMID- 20735871
OWN - NLM
STAT- MEDLINE
DCOM- 20100920
LR  - 20101104
IS  - 1876-8784 (Electronic)
IS  - 0028-2162 (Linking)
VI  - 154
DP  - 2010
TI  - [IVF surrogacy after embryo transfer abroad. Dilemmas of pregnancy follow-up].
PG  - A1777
AB  - A 43-year-old female, gravida 3, para 2, who was 9 weeks pregnant, presented
      herself as a surrogate mother for a 33-year-old couple at our outpatient clinic
      in Heerlen, the Netherlands, for pregnancy follow-up. As she had not passed the
      selection procedure in the Netherlands (VU University Medical Center, Amsterdam),
      IVF using the gametes of the prospective parents and embryo transfer was
      performed in Belgium. We discussed the management of possible problems and
      complications during pregnancy and delivery. After an uneventful pregnancy and
      delivery a healthy boy was taken home by the donor couple. In the Netherlands,
      high-tech surrogate motherhood under strict non-commercial conditions has been
      accepted by law since 1997. Since the inclusion criteria are very strict, some
      couples seem to find a way to have their wish fulfilled abroad. Uniformity of the
      IVF surrogacy legislation in Europe is necessary to discourage this practice.
      When this situation occurs nevertheless, it is important that doctors involved
      know how to handle the (often unknown) medical, ethical, legal, emotional and
      psychosocial aspects associated with high-tech IVF-surrogacy.
FAU - Winkel, Esther
AU  - Winkel E
AD  - Atrium Medisch Centrum Parkstad, afd. Gynaecologie, Heerlen, the Netherlands.
      winkelesther@hotmail.com
FAU - Roumen, Frans J M E
AU  - Roumen FJ
FAU - Dermout, Sylvia M
AU  - Dermout SM
LA  - dut
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - Draagmoederschap na ivf in het buitenland: dilemma's bij de begeleiding.
PL  - Netherlands
TA  - Ned Tijdschr Geneeskd
JT  - Nederlands tijdschrift voor geneeskunde
JID - 0400770
SB  - IM
MH  - Adult
MH  - *Embryo Transfer
MH  - Female
MH  - Fertilization in Vitro/*legislation & jurisprudence/psychology
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - Netherlands
MH  - Pregnancy
MH  - Prenatal Care/*standards
MH  - *Surrogate Mothers/legislation & jurisprudence/psychology
EDAT- 2010/08/26 06:00
MHDA- 2010/09/21 06:00
CRDT- 2010/08/26 06:00
PHST- 2010/08/26 06:00 [entrez]
PHST- 2010/08/26 06:00 [pubmed]
PHST- 2010/09/21 06:00 [medline]
PST - ppublish
SO  - Ned Tijdschr Geneeskd. 2010;154:A1777.


PMID- 20735502
OWN - NLM
STAT- MEDLINE
DCOM- 20110408
LR  - 20211028
IS  - 1365-2648 (Electronic)
IS  - 0309-2402 (Linking)
VI  - 66
IP  - 11
DP  - 2010 Nov
TI  - Everyday ethics: ethical issues and stress in nursing practice.
PG  - 2510-9
LID - 10.1111/j.1365-2648.2010.05425.x [doi]
AB  - AIM: This paper is a report of a study of the type, frequency, and level of
      stress of ethical issues encountered by nurses in their everyday practice.
      BACKGROUND: Everyday ethical issues in nursing practice attract little attention 
      but can create stress for nurses. Nurses often feel uncomfortable in addressing
      the ethical issues they encounter in patient care. METHODS: A self-administered
      survey was sent in 2004 to 1000 nurses in four states in four different census
      regions of the United States of America. The adjusted response rate was 52%. Data
      were analysed using descriptive statistics, cross-tabulations and Pearson
      correlations. RESULTS: A total of 422 questionnaires were used in the analysis.
      The five most frequently occurring and most stressful ethical and patient care
      issues were protecting patients' rights; autonomy and informed consent to
      treatment; staffing patterns; advanced care planning; and surrogate
      decision-making. Other common occurrences were unethical practices of healthcare 
      professionals; breaches of patient confidentiality or right to privacy; and
      end-of-life decision-making. Younger nurses and those with fewer years of
      experience encountered ethical issues more frequently and reported higher levels 
      of stress. Nurses from different regions also experienced specific types of
      ethical problems more commonly. CONCLUSION: Nurses face daily ethical challenges 
      in the provision of quality care. To retain nurses, targeted ethics-related
      interventions that address caring for an increasingly complex patient population 
      are needed.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Ulrich, Connie M
AU  - Ulrich CM
AD  - Center for Bioethics, Department of Medical Ethics, and Leonard Davis Institute
      of Health Economics, New Courtland Center for Transitions and Health, School of
      Nursing, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
      culrich@nursing.upenn.edu
FAU - Taylor, Carol
AU  - Taylor C
FAU - Soeken, Karen
AU  - Soeken K
FAU - O'Donnell, Patricia
AU  - O'Donnell P
FAU - Farrar, Adrienne
AU  - Farrar A
FAU - Danis, Marion
AU  - Danis M
FAU - Grady, Christine
AU  - Grady C
LA  - eng
GR  - Z99 CL999999/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20100823
PL  - England
TA  - J Adv Nurs
JT  - Journal of advanced nursing
JID - 7609811
SB  - IM
MH  - Advance Directives/ethics
MH  - Age Factors
MH  - Bioethical Issues
MH  - Burnout, Professional/*epidemiology/psychology
MH  - Clinical Competence
MH  - Conflict of Interest
MH  - Cross-Sectional Studies
MH  - Decision Making/ethics
MH  - *Ethics, Nursing
MH  - Female
MH  - Humans
MH  - *Job Satisfaction
MH  - Male
MH  - Middle Aged
MH  - Nursing Research
MH  - *Nursing Staff/psychology/supply & distribution
MH  - Patient Rights/*ethics
MH  - Personnel Staffing and Scheduling/ethics
MH  - Personnel Turnover
MH  - Surveys and Questionnaires
MH  - Terminal Care/ethics
MH  - United States/epidemiology
PMC - PMC3865804
MID - NIHMS223615
EDAT- 2010/08/26 06:00
MHDA- 2011/04/09 06:00
CRDT- 2010/08/26 06:00
PHST- 2010/08/26 06:00 [entrez]
PHST- 2010/08/26 06:00 [pubmed]
PHST- 2011/04/09 06:00 [medline]
AID - JAN5425 [pii]
AID - 10.1111/j.1365-2648.2010.05425.x [doi]
PST - ppublish
SO  - J Adv Nurs. 2010 Nov;66(11):2510-9. doi: 10.1111/j.1365-2648.2010.05425.x. Epub
      2010 Aug 23.


PMID- 20735244
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20220316
IS  - 1942-7905 (Electronic)
IS  - 1942-7891 (Linking)
VI  - 13
IP  - 4
DP  - 2010 Aug
TI  - Is the United States ready to embrace concierge medicine?
PG  - 177-82
LID - 10.1089/pop.2009.0052 [doi]
AB  - Concierge medicine (also called retainer practices or consumer-focused care)
      represents a new approach to the delivery of primary care. This model involves
      more personalized attention and greater resources for individual patients, thus
      limiting the number of patients who can be served at each practice. All enrolled 
      members must pay an annual membership fee or retainer. Given the short history
      and novelty of concierge medicine, this article explores the clinical, economic, 
      marketing, ethical, and policy implications of this innovative approach to
      primary care.
FAU - French, Michael T
AU  - French MT
AD  - Departments of Sociology, Epidemiology and Public Health, and Economics, Health
      Economics Research Group, Coral Gables, Florida, USA. mfrench@miami.edu
FAU - Homer, Jenny F
AU  - Homer JF
FAU - Klevay, Shay
AU  - Klevay S
FAU - Goldman, Edward
AU  - Goldman E
FAU - Ullmann, Steven G
AU  - Ullmann SG
FAU - Kahn, Barbara E
AU  - Kahn BE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Popul Health Manag
JT  - Population health management
JID - 101481266
SB  - IM
MH  - *Contracts/legislation & jurisprudence
MH  - *Diffusion of Innovation
MH  - Health Services Accessibility
MH  - Humans
MH  - *Physician-Patient Relations
MH  - Practice Management, Medical/organization & administration
MH  - Primary Health Care
MH  - United States
EDAT- 2010/08/26 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/26 06:00
PHST- 2010/08/26 06:00 [entrez]
PHST- 2010/08/26 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1089/pop.2009.0052 [doi]
PST - ppublish
SO  - Popul Health Manag. 2010 Aug;13(4):177-82. doi: 10.1089/pop.2009.0052.


PMID- 20735219
OWN - NLM
STAT- MEDLINE
DCOM- 20101210
LR  - 20100825
IS  - 1748-6963 (Electronic)
IS  - 1743-5889 (Linking)
VI  - 5
IP  - 6
DP  - 2010 Aug
TI  - Nanotechnology contributions to the pharmacotherapy of pediatric HIV: a dual
      scientific and ethical challenge and a still pending agenda.
PG  - 833-7
LID - 10.2217/nnm.10.64 [doi]
FAU - Sosnik, Alejandro
AU  - Sosnik A
LA  - eng
PT  - Editorial
PL  - England
TA  - Nanomedicine (Lond)
JT  - Nanomedicine (London, England)
JID - 101278111
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - Anti-HIV Agents/*therapeutic use
MH  - Child
MH  - Child, Preschool
MH  - HIV Infections/*drug therapy
MH  - Humans
MH  - *Nanotechnology
EDAT- 2010/08/26 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/26 06:00
PHST- 2010/08/26 06:00 [entrez]
PHST- 2010/08/26 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.2217/nnm.10.64 [doi]
PST - ppublish
SO  - Nanomedicine (Lond). 2010 Aug;5(6):833-7. doi: 10.2217/nnm.10.64.


PMID- 20735150
OWN - NLM
STAT- MEDLINE
DCOM- 20110627
LR  - 20131121
IS  - 1547-6901 (Electronic)
IS  - 1547-691X (Linking)
VI  - 7
IP  - 4
DP  - 2010 Oct-Dec
TI  - Present and future of in vitro immunotoxicology in drug development.
PG  - 255-67
LID - 10.3109/1547691X.2010.509848 [doi]
AB  - The realization, that the immune system can be the target of many chemicals
      including environmental contaminants and drugs with potentially adverse effects
      on the host's health, has raised serious concerns within the public and the
      regulatory agencies. At present, assessment of immunotoxic effects relies on
      different animal models and several assays have been proposed to characterize
      immunosuppression and sensitization. The use of whole animals, however, presents 
      many secondary issues, such as expense, ethical concerns, and eventual relevance 
      to risk assessment for humans. Furthermore, due to the new policy on chemicals
      (REACH), in the European Union, in vitro methods will play a major role in the
      near future. In addition, there is still a lack of human cell-based
      immunotoxicity assays for predicting the toxicity of xenobiotics toward the
      immune system in a simple, fast, economical, and reliable way. Hypersensitivity
      and immunosuppression, for which animal models have been developed and validated,
      are considered the primary focus for developing in vitro methods in
      immunotoxicology. Nevertheless, in vitro assays, as well as in vivo models, to
      detect immunostimulation and autoimmunity are also needed. Even if no validated
      alternative in vitro tests to assess immunotoxicity exist, in the last decade,
      much progress has been made toward these assays. Such models can be, at least,
      used for the pre-screening and hazard identification of unintended
      immunosuppression and contact hypersensitivity of direct immunotoxicants.
      Following a brief introduction to immunotoxicology and to in vivo models use to
      assess immunotoxicity, this manuscript will review the state-of-the-art in the
      field of in vitro immunotoxicity.
FAU - Galbiati, Valentina
AU  - Galbiati V
AD  - Laboratory of Toxicology, Department of Pharmacological Sciences, Faculty of
      Pharmacy, University of Milan, Milan, Italy.
FAU - Mitjans, Montserrat
AU  - Mitjans M
FAU - Corsini, Emanuela
AU  - Corsini E
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100824
PL  - England
TA  - J Immunotoxicol
JT  - Journal of immunotoxicology
JID - 101201960
RN  - 0 (Biological Products)
RN  - 0 (Hazardous Substances)
SB  - IM
MH  - Animals
MH  - Biological Products/*immunology
MH  - Drug Evaluation, Preclinical/trends
MH  - European Union
MH  - Government Regulation
MH  - Hazardous Substances/immunology
MH  - Humans
MH  - Immune System/*drug effects
MH  - *Immunologic Techniques
MH  - *Immunomodulation
MH  - Models, Animal
MH  - Toxicology/methods
EDAT- 2010/08/26 06:00
MHDA- 2011/06/28 06:00
CRDT- 2010/08/26 06:00
PHST- 2010/08/26 06:00 [entrez]
PHST- 2010/08/26 06:00 [pubmed]
PHST- 2011/06/28 06:00 [medline]
AID - 10.3109/1547691X.2010.509848 [doi]
PST - ppublish
SO  - J Immunotoxicol. 2010 Oct-Dec;7(4):255-67. doi: 10.3109/1547691X.2010.509848.
      Epub 2010 Aug 24.


PMID- 20734677
OWN - NLM
STAT- MEDLINE
DCOM- 20101005
LR  - 20100825
IS  - 0324-0959 (Print)
IS  - 0324-0959 (Linking)
VI  - 49
IP  - 2
DP  - 2010
TI  - [Oocyte and embryo donation and surrogacy. Religious, medico-social, ethical,
      financial and legal problems].
PG  - 43-6
AB  - The authors quote and discuss the postulates of the Orthodox, Jewish, Catholic
      and Islamic religions towards ART as well as worldwide legislations and standards
      and the attitude of female students of medicine in Varna. Indications of oocyte
      and embryo donation and surrogacy are proposed but all kinds or surrogacy should 
      be permitted. The ART legislation and standards in Bulgaria should be thoroughly 
      revised.
FAU - Kozovski, I
AU  - Kozovski I
FAU - Kovachev, M
AU  - Kovachev M
FAU - Angelova, K
AU  - Angelova K
FAU - Alexandrov, K
AU  - Alexandrov K
FAU - Kozovski, G
AU  - Kozovski G
FAU - Markova, V
AU  - Markova V
LA  - bul
PT  - English Abstract
PT  - Journal Article
PL  - Bulgaria
TA  - Akush Ginekol (Sofiia)
JT  - Akusherstvo i ginekologiia
JID - 0370455
SB  - IM
MH  - Bulgaria
MH  - Embryo Transfer/economics/ethics/standards
MH  - Female
MH  - Fertilization in Vitro/economics/ethics/*legislation & jurisprudence/standards
MH  - Humans
MH  - Oocyte Donation/economics/ethics/*legislation & jurisprudence/standards
MH  - Pregnancy
MH  - Religion
MH  - Surrogate Mothers/*legislation & jurisprudence
EDAT- 2010/08/26 06:00
MHDA- 2010/10/06 06:00
CRDT- 2010/08/26 06:00
PHST- 2010/08/26 06:00 [entrez]
PHST- 2010/08/26 06:00 [pubmed]
PHST- 2010/10/06 06:00 [medline]
PST - ppublish
SO  - Akush Ginekol (Sofiia). 2010;49(2):43-6.


PMID- 20734404
OWN - NLM
STAT- MEDLINE
DCOM- 20101122
LR  - 20101028
IS  - 1545-5017 (Electronic)
IS  - 1545-5009 (Linking)
VI  - 55
IP  - 7
DP  - 2010 Dec 15
TI  - Oncolytic virotherapy reaches adolescence.
PG  - 1253-63
LID - 10.1002/pbc.22724 [doi]
AB  - Lytic viruses kill cells as a consequence of their normal replication life cycle.
      The idea of harnessing viruses to kill cancer cells arose over a century ago,
      before viruses were even discovered, from medical case reports of infections
      associated with cancer remissions. Since then, there has been no shortage of
      hype, hope, or fear regarding the prospect of oncolytic virotherapy for cancer.
      Early developments in the field included encouraging antitumor efficacy both in
      animal studies in the 1920s-1940s and in human clinical trials in the
      1950s-1970s. Despite its long-standing history, oncolytic virotherapy was an idea
      ahead of its time. Without needed advances in molecular biology, virology,
      immunology, and clinical research ethics, early clinical trials resulted in
      infectious complications and were fraught with controversial research conduct, so
      that enthusiasm in the medical community waned. Oncolytic virotherapy is now
      experiencing a major growth spurt, having sustained numerous laboratory advances 
      and undergone multiple encouraging adult clinical trials, and is now witnessing
      the emergence of pediatric trials. Here we review the history and salient biology
      of the field, including preclinical and clinical data, with a special emphasis on
      those agents now being tested in pediatric cancer patients.
CI  - Copyright (c) 2010 Wiley-Liss, Inc.
FAU - Hammill, Adrienne M
AU  - Hammill AM
AD  - Division of Hematology/Oncology, Cincinnati Children's Hospital Medical Center,
      University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
FAU - Conner, Joseph
AU  - Conner J
FAU - Cripe, Timothy P
AU  - Cripe TP
LA  - eng
GR  - R01-CA114004/CA/NCI NIH HHS/United States
GR  - R21-CA133663/CA/NCI NIH HHS/United States
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100823
PL  - United States
TA  - Pediatr Blood Cancer
JT  - Pediatric blood & cancer
JID - 101186624
SB  - IM
MH  - Animals
MH  - Clinical Trials as Topic
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - *Oncolytic Virotherapy/history
MH  - *Oncolytic Viruses/physiology
EDAT- 2010/08/25 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/25 06:00
PHST- 2010/03/23 00:00 [received]
PHST- 2010/06/01 00:00 [accepted]
PHST- 2010/08/25 06:00 [entrez]
PHST- 2010/08/25 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1002/pbc.22724 [doi]
PST - ppublish
SO  - Pediatr Blood Cancer. 2010 Dec 15;55(7):1253-63. doi: 10.1002/pbc.22724. Epub
      2010 Aug 23.


PMID- 20734079
OWN - NLM
STAT- Publisher
LR  - 20191120
IS  - 1432-2218 (Electronic)
IS  - 0930-2794 (Linking)
DP  - 2010 Aug 24
TI  - Endoscopic minimally invasive thyroidectomy: ethical and patients safety
      considerations on the first clinical experience of an innovative approach.
FAU - Benhidjeb, Tahar
AU  - Benhidjeb T
AD  - Department of General, Visceral and Thoracic Surgery, University Medical Center
      Hamburg-Eppendorf, Hamburg, Germany, t.benhidjeb@uke.de.
FAU - Witzel, Kai
AU  - Witzel K
FAU - Burghardt, Jens
AU  - Burghardt J
FAU - Barlehner, Eckhard
AU  - Barlehner E
FAU - Stark, Michael
AU  - Stark M
FAU - Mann, Oliver
AU  - Mann O
LA  - eng
PT  - Journal Article
DEP - 20100824
PL  - Germany
TA  - Surg Endosc
JT  - Surgical endoscopy
JID - 8806653
EDAT- 2010/08/25 06:00
MHDA- 2010/08/25 06:00
CRDT- 2010/08/25 06:00
PHST- 2010/08/25 06:00 [entrez]
PHST- 2010/08/25 06:00 [pubmed]
PHST- 2010/08/25 06:00 [medline]
AID - 10.1007/s00464-010-1290-9 [doi]
PST - aheadofprint
SO  - Surg Endosc. 2010 Aug 24. doi: 10.1007/s00464-010-1290-9.


PMID- 20734066
OWN - NLM
STAT- Publisher
LR  - 20191120
IS  - 1432-2218 (Electronic)
IS  - 0930-2794 (Linking)
DP  - 2010 Aug 24
TI  - Endoscopic minimally invasive thyroidectomy (eMIT): some clarifications regarding
      the idea, development, preclinical studies, and application in humans.
AB  - BACKGROUND: The transoral endoscopic approach for thyroid surgery was based on a 
      previous attempt to reach the thyroid gland by an axilloscope. In contrast to
      this single-port access, endoscopic minimally invasive thyroidectomy (eMIT) uses 
      three access points (sublingual and bivestibular). This results in a sufficient
      triangulation of instruments, making surgical procedures in the anterior neck
      region possible. METHODS: The idea and development of the eMIT technique are
      described in detail. Anatomic studies, the development of the surgical access in 
      a cadaver study, and the animal study for safety and feasibility of this
      transoral endoscopic approach for surgery of the anterior neck are outlined.
      Also, the foundations and ethical aspects are addressed in the context of
      developing a surgical innovation, which resulted in the first clinical
      application of this technique in humans. RESULTS: The preclinical studies
      regarding endoscopic minimally invasive thyroidectomy proofed feasibility in a
      human cadaver studies as well as safety in a short-time survival animal study.
      The first clinical application in a 53-year old patient was successful without
      any significant complications; expected benefits (no postoperative pain or
      dysphagia, no visible scar) could be demonstrated. CONCLUSIONS: The eMIT
      technique represents a promising new surgical approach for endoscopic surgery in 
      the anterior neck region. The whole development was based on principles for
      surgical innovation published after the authors' preclinical studies. At this
      writing, after an initial clinical study with humans, the time has come to
      compare this new technique with other endoscopic and minimally invasive
      approaches in a prospective randomized multicenter trial.
FAU - Wilhelm, Thomas
AU  - Wilhelm T
AD  - Department of Otolaryngology, Head/Neck & Facial Plastic Surgery, HELIOS Klinikum
      Borna, Rudolf-Virchow-Strasse 2, D-04552, Borna, Germany,
      thomas.wilhelm@helios-kliniken.de.
FAU - Metzig, Andreas
AU  - Metzig A
LA  - eng
PT  - Journal Article
DEP - 20100824
PL  - Germany
TA  - Surg Endosc
JT  - Surgical endoscopy
JID - 8806653
EDAT- 2010/08/25 06:00
MHDA- 2010/08/25 06:00
CRDT- 2010/08/25 06:00
PHST- 2010/08/25 06:00 [entrez]
PHST- 2010/08/25 06:00 [pubmed]
PHST- 2010/08/25 06:00 [medline]
AID - 10.1007/s00464-010-1312-7 [doi]
PST - aheadofprint
SO  - Surg Endosc. 2010 Aug 24. doi: 10.1007/s00464-010-1312-7.


PMID- 20733502
OWN - NLM
STAT- MEDLINE
DCOM- 20110131
LR  - 20220210
IS  - 1530-0366 (Electronic)
IS  - 1098-3600 (Linking)
VI  - 12
IP  - 10
DP  - 2010 Oct
TI  - Confronting real time ethical, legal, and social issues in the Electronic Medical
      Records and Genomics (eMERGE) Consortium.
PG  - 616-20
LID - 10.1097/GIM.0b013e3181efdbd0 [doi]
FAU - Clayton, Ellen Wright
AU  - Clayton EW
AD  - Center for Biomedical Ethics and Society, Vanderbilt University, Nashville, TN,
      USA. ellen.clayton@vanderbilt.edu
FAU - Smith, Maureen
AU  - Smith M
FAU - Fullerton, Stephanie M
AU  - Fullerton SM
FAU - Burke, Wylie
AU  - Burke W
FAU - McCarty, Catherine A
AU  - McCarty CA
FAU - Koenig, Barbara A
AU  - Koenig BA
FAU - McGuire, Amy L
AU  - McGuire AL
FAU - Beskow, Laura M
AU  - Beskow LM
FAU - Dressler, Lynn
AU  - Dressler L
FAU - Lemke, Amy A
AU  - Lemke AA
FAU - Ramos, Erin M
AU  - Ramos EM
FAU - Rodriguez, Laura Lyman
AU  - Rodriguez LL
CN  - Consent and Community Consultation Working Group of the eMERGE Consortium
LA  - eng
GR  - U01-HG-004610/HG/NHGRI NIH HHS/United States
GR  - U01 HG006375/HG/NHGRI NIH HHS/United States
GR  - U01-HG-04603/HG/NHGRI NIH HHS/United States
GR  - U01 HG004603/HG/NHGRI NIH HHS/United States
GR  - U01HG004609/HG/NHGRI NIH HHS/United States
GR  - U01 HG004609/HG/NHGRI NIH HHS/United States
GR  - U01 HG004599/HG/NHGRI NIH HHS/United States
GR  - U01 HG004610/HG/NHGRI NIH HHS/United States
GR  - U01-HG-004608/HG/NHGRI NIH HHS/United States
GR  - U01 HG004608/HG/NHGRI NIH HHS/United States
GR  - U01-HG-04599/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Genet Med
JT  - Genetics in medicine : official journal of the American College of Medical
      Genetics
JID - 9815831
SB  - IM
MH  - Community-Based Participatory Research
MH  - Confidentiality/ethics/legislation & jurisprudence
MH  - *Electronic Health Records/ethics/legislation & jurisprudence
MH  - Ethics Committees, Research
MH  - Ethics, Medical
MH  - *Genetic Research/ethics/legislation & jurisprudence
MH  - *Genome-Wide Association Study/ethics/methods
MH  - Genomics/ethics/legislation & jurisprudence
MH  - Humans
MH  - Information Dissemination
MH  - Informed Consent
MH  - Interinstitutional Relations
MH  - National Human Genome Research Institute (U.S.)
MH  - National Institutes of Health (U.S.)
MH  - Physician-Patient Relations/ethics
MH  - Research Design
MH  - United States
PMC - PMC3090678
MID - NIHMS287409
IR  - Burke W
FIR - Burke, Wylie
IR  - Fullerton SM
FIR - Fullerton, Stephanie M
IR  - Jarvik GP
FIR - Jarvik, Gail P
IR  - Ludman E
FIR - Ludman, Evette
IR  - Trinidad SB
FIR - Trinidad, Susan B
IR  - McCarty C
FIR - McCarty, Catherine
IR  - Fost NC
FIR - Fost, Norman C
IR  - Koenig B
FIR - Koenig, Barbara
IR  - Wu J
FIR - Wu, Joel
IR  - Eisenberg L
FIR - Eisenberg, Leah
IR  - Hellyer JH
FIR - Hellyer, Joan Henriksen
IR  - Smith M
FIR - Smith, Maureen
IR  - Lemke AA
FIR - Lemke, Amy A
IR  - Wolf W
FIR - Wolf, Wendy
IR  - Clayton EW
FIR - Clayton, Ellen Wright
IR  - Malin B
FIR - Malin, Bradley
IR  - Brothers K
FIR - Brothers, Kyle
IR  - McGuire AL
FIR - McGuire, Amy L
IR  - Beskow L
FIR - Beskow, Laura
IR  - Somkin C
FIR - Somkin, Carol
IR  - Lam A
FIR - Lam, Amy
IR  - Wilfond B
FIR - Wilfond, Ben
IR  - Tabor H
FIR - Tabor, Holly
IR  - Dressler L
FIR - Dressler, Lynn
IR  - Henderson G
FIR - Henderson, Gail
IR  - Rodriguez LL
FIR - Rodriguez, Laura Lyman
IR  - Ramos E
FIR - Ramos, Erin
IR  - Manolio T
FIR - Manolio, Teri
EDAT- 2010/08/25 06:00
MHDA- 2011/02/01 06:00
CRDT- 2010/08/25 06:00
PHST- 2010/08/25 06:00 [entrez]
PHST- 2010/08/25 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
AID - 10.1097/GIM.0b013e3181efdbd0 [doi]
AID - S1098-3600(21)01953-5 [pii]
PST - ppublish
SO  - Genet Med. 2010 Oct;12(10):616-20. doi: 10.1097/GIM.0b013e3181efdbd0.


PMID- 20733495
OWN - NLM
STAT- MEDLINE
DCOM- 20110121
LR  - 20100930
IS  - 1473-6578 (Electronic)
IS  - 0951-7367 (Linking)
VI  - 23
IP  - 6
DP  - 2010 Nov
TI  - Ethical aspects of personality disorders.
PG  - 546-9
LID - 10.1097/YCO.0b013e32833e040d [doi]
AB  - PURPOSE OF REVIEW: To review recent literature around the controversial diagnosis
      of personality disorder, and to assess the ethical aspects of its status as a
      medical disorder. RECENT FINDINGS: The diagnostic currency of personality
      disorder as a psychiatric/medical disorder has a longstanding history of ethical 
      and social challenges through critiques of the medicalization of deviance. More
      recently controversies by reflexive physicians around the inclusion of the
      category in the forthcoming revisions of International Classification of Diseases
      and Diagnostic and Statistical Manual of Mental Disorders classifications reflect
      the problems of value-laden criteria, with the diagnostic category being severely
      challenged from within psychiatry as well as from without. SUMMARY: The clinical 
      diagnostic criteria for extremely value-laden psychiatric conditions such as
      personality disorder need to be analyzed through the lens of values-based
      medicine, as well as through clinical evidence, as the propensity for political
      and sociolegal appropriation of the categories can render their clinical and
      diagnostic value meaningless.
FAU - Bendelow, Gillian
AU  - Bendelow G
AD  - School of Law, Politics and Sociology, University of Sussex, Brighton, East
      Sussex, UK. g.a.bendelow@sussex.ac.uk
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Psychiatry
JT  - Current opinion in psychiatry
JID - 8809880
SB  - IM
MH  - Antisocial Personality Disorder/diagnosis/psychology
MH  - Dangerous Behavior
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Humans
MH  - Personality Disorders/*diagnosis/psychology
MH  - Psychiatry/*ethics
MH  - Self-Injurious Behavior/diagnosis/psychology
MH  - Social Values
EDAT- 2010/08/25 06:00
MHDA- 2011/01/22 06:00
CRDT- 2010/08/25 06:00
PHST- 2010/08/25 06:00 [entrez]
PHST- 2010/08/25 06:00 [pubmed]
PHST- 2011/01/22 06:00 [medline]
AID - 10.1097/YCO.0b013e32833e040d [doi]
PST - ppublish
SO  - Curr Opin Psychiatry. 2010 Nov;23(6):546-9. doi: 10.1097/YCO.0b013e32833e040d.


PMID- 20733475
OWN - NLM
STAT- MEDLINE
DCOM- 20100928
LR  - 20210107
IS  - 1873-233X (Electronic)
IS  - 0029-7844 (Linking)
VI  - 116
IP  - 3
DP  - 2010 Sep
TI  - Committee opinion no. 466: ethical considerations for performing gynecologic
      surgery in low-resource settings abroad.
PG  - 793-799
LID - 10.1097/AOG.0b013e3181f680b2 [doi]
AB  - International humanitarian medical efforts provide essential services to patients
      who would not otherwise have access to specific health care services. The
      Committees on Ethics and Global Women's Health of the American College of
      Obstetricians and Gynecologists encourage College Fellows and other health care
      professionals to participate in international humanitarian medical efforts for
      this reason. However, such programs present Fellows with a unique set of
      practical and ethical challenges. It is important for health care providers to
      consider these challenges before participating in international surgical efforts 
      in these settings. Health care professionals should ensure that they have the
      necessary surgical competence and training, including sufficient mentorship,
      prior to functioning as the primary surgeon abroad. Before they perform surgery, 
      health care professionals should ensure that patients have access to adequate
      medical resources and preoperative and postoperative care. They should be willing
      and prepared to postpone or cancel surgery when the standards of ethical medical 
      care cannot be met and the members of the surgical team believe that the best
      interest of the patient cannot be achieved with the current available resources. 
      Health care professionals' efforts should contribute to the long-term well-being 
      of the patients and the communities being served through the ethical practice of 
      medicine, responsible conduct of research, and investment in the sustainability
      of services. The care of the patient should be the highest priority for those
      participating in these medical programs.
LA  - eng
PT  - Journal Article
PT  - Practice Guideline
PL  - United States
TA  - Obstet Gynecol
JT  - Obstetrics and gynecology
JID - 0401101
SB  - IM
MH  - *Developing Countries
MH  - Female
MH  - *Gynecologic Surgical Procedures
MH  - Humans
MH  - Vaginal Fistula/surgery
EDAT- 2010/08/25 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/08/25 06:00
PHST- 2010/08/25 06:00 [entrez]
PHST- 2010/08/25 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - 10.1097/AOG.0b013e3181f680b2 [doi]
AID - 00006250-201009000-00044 [pii]
PST - ppublish
SO  - Obstet Gynecol. 2010 Sep;116(3):793-799. doi: 10.1097/AOG.0b013e3181f680b2.


PMID- 20733458
OWN - NLM
STAT- MEDLINE
DCOM- 20100928
LR  - 20210107
IS  - 1873-233X (Electronic)
IS  - 0029-7844 (Linking)
VI  - 116
IP  - 3
DP  - 2010 Sep
TI  - Is there a doctor in the house? Standards of physician availability for laboring 
      women.
PG  - 723-727
LID - 10.1097/AOG.0b013e3181ed7ba5 [doi]
AB  - Unexpected emergencies requiring urgent intervention can arise in the course of
      labor even among uncomplicated pregnancies in low-risk women. The possibility of 
      such emergencies requires that responsible practitioners be available for
      management. The recent National Institutes of Health-sponsored consensus
      conference on vaginal birth after cesarean delivery highlighted this issue in
      discussing alternate standards of "ready" and "immediate" availability. The
      merits, feasibility, and ethics of alternate systems for coverage of all laboring
      women have not been widely or previously discussed and are considered in this
      opinion. Although there are potential advantages to having a responsible
      practitioner immediately available, logistic and economic considerations will
      make immediate availability unfeasible in all centers and systems, particularly
      on smaller services where distance or other factors may limit the option of
      consolidation (ie, the merging of different hospitals' obstetric services). We
      discuss training, systems, and planning to optimize response to emergencies in
      all systems, whether practitioners are readily or immediately available. Finally,
      we suggest that the ethical principle of respect for autonomy argues that
      particularly where alternate systems exist, practitioners and patients discuss
      the details, merits, and limitations of individual centers' clinical systems and 
      plans for responding to emergencies.
FAU - Minkoff, Howard
AU  - Minkoff H
AD  - From the Department of Obstetrics and Gynecology, Maimonides Medical Center,
      State University of New York Downstate, Brooklyn, New York; and the Department of
      Obstetrics and Gynecology and Massachusetts General Hospital, Harvard Medical
      School, Boston, Massachusetts.
FAU - Ecker, Jeffrey
AU  - Ecker J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Obstet Gynecol
JT  - Obstetrics and gynecology
JID - 0401101
SB  - IM
MH  - Delivery, Obstetric/ethics/*standards
MH  - Female
MH  - Health Services Accessibility/ethics/*standards
MH  - Humans
MH  - Obstetrics/ethics/*standards
MH  - Pregnancy
EDAT- 2010/08/25 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/08/25 06:00
PHST- 2010/08/25 06:00 [entrez]
PHST- 2010/08/25 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - 10.1097/AOG.0b013e3181ed7ba5 [doi]
AID - 00006250-201009000-00025 [pii]
PST - ppublish
SO  - Obstet Gynecol. 2010 Sep;116(3):723-727. doi: 10.1097/AOG.0b013e3181ed7ba5.


PMID- 20732777
OWN - NLM
STAT- MEDLINE
DCOM- 20101210
LR  - 20121003
IS  - 1097-6809 (Electronic)
IS  - 0741-5214 (Linking)
VI  - 52
IP  - 5
DP  - 2010 Nov
TI  - The ethical hierarchy of do not resuscitate orders: never say never.
PG  - 1384-6
LID - 10.1016/j.jvs.2010.08.001 [doi]
FAU - Jones, James W
AU  - Jones JW
AD  - The Center for Medical Ethics and Health Policy, Baylor College of Medicine,
      Montgomery, TX 77356, USA. jwjones@bcm.tmc.edu
FAU - McCullough, Laurence B
AU  - McCullough LB
LA  - eng
PT  - Journal Article
DEP - 20100821
PL  - United States
TA  - J Vasc Surg
JT  - Journal of vascular surgery
JID - 8407742
SB  - IM
MH  - Decision Making
MH  - Depression/*psychology
MH  - Female
MH  - *Heart-Assist Devices
MH  - Humans
MH  - Informed Consent
MH  - Mental Competency
MH  - Middle Aged
MH  - Myocardial Infarction/psychology/*therapy
MH  - Personal Autonomy
MH  - Quality of Life
MH  - Resuscitation Orders/*ethics/legislation & jurisprudence
EDAT- 2010/08/25 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/25 06:00
PHST- 2010/08/25 06:00 [entrez]
PHST- 2010/08/25 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S0741-5214(10)01836-7 [pii]
AID - 10.1016/j.jvs.2010.08.001 [doi]
PST - ppublish
SO  - J Vasc Surg. 2010 Nov;52(5):1384-6. doi: 10.1016/j.jvs.2010.08.001. Epub 2010 Aug
      21.


PMID- 20731643
OWN - NLM
STAT- MEDLINE
DCOM- 20111109
LR  - 20211020
IS  - 1541-0420 (Electronic)
IS  - 0006-341X (Linking)
VI  - 67
IP  - 2
DP  - 2011 Jun
TI  - Incorporating individual and collective ethics into phase I cancer trial designs.
PG  - 596-603
LID - 10.1111/j.1541-0420.2010.01471.x [doi]
AB  - A general framework is proposed for Bayesian model based designs of Phase I
      cancer trials, in which a general criterion for coherence (Cheung, 2005,
      Biometrika 92, 863-873) of a design is also developed. This framework can
      incorporate both "individual" and "collective" ethics into the design of the
      trial. We propose a new design that minimizes a risk function composed of two
      terms, with one representing the individual risk of the current dose and the
      other representing the collective risk. The performance of this design, which is 
      measured in terms of the accuracy of the estimated target dose at the end of the 
      trial, the toxicity and overdose rates, and certain loss functions reflecting the
      individual and collective ethics, is studied and compared with existing Bayesian 
      model based designs and is shown to have better performance than existing
      designs.
CI  - (c) 2010, The International Biometric Society.
FAU - Bartroff, Jay
AU  - Bartroff J
AD  - Department of Mathematics, University of Southern California, Los Angeles,
      California 90089, USA. bartroff@usc.edu
FAU - Leung Lai, Tze
AU  - Leung Lai T
LA  - eng
GR  - P30 CA124435/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20100819
PL  - United States
TA  - Biometrics
JT  - Biometrics
JID - 0370625
SB  - IM
MH  - Animals
MH  - Bayes Theorem
MH  - Clinical Trials as Topic/ethics/methods/*standards
MH  - *Drug Dosage Calculations
MH  - Ethics
MH  - Neoplasms/*drug therapy
MH  - Research Design/*standards
MH  - Risk Assessment
PMC - PMC4485382
MID - NIHMS691939
EDAT- 2010/08/25 06:00
MHDA- 2011/11/10 06:00
CRDT- 2010/08/25 06:00
PHST- 2010/08/25 06:00 [entrez]
PHST- 2010/08/25 06:00 [pubmed]
PHST- 2011/11/10 06:00 [medline]
AID - BIOM1471 [pii]
AID - 10.1111/j.1541-0420.2010.01471.x [doi]
PST - ppublish
SO  - Biometrics. 2011 Jun;67(2):596-603. doi: 10.1111/j.1541-0420.2010.01471.x. Epub
      2010 Aug 19.


PMID- 20731257
OWN - NLM
STAT- MEDLINE
DCOM- 20100929
LR  - 20191210
IS  - 0026-4075 (Print)
IS  - 0026-4075 (Linking)
VI  - 175
IP  - 8
DP  - 2010 Aug
TI  - Conflicts between ethics and law for military mental health providers.
PG  - 548-53
AB  - Military mental health providers routinely experience mixed-agency ethical
      dilemmas when obligations to patients and the military conflict. Particularly
      difficult mixed-agency dilemmas occur when a military psychiatrist, psychologist,
      or social worker encounters an apparent conflict between an ethical
      obligation--enumerated in a professional code of ethics--and a federal statute.
      This article explores ethical-legal conflicts for uniformed mental health
      providers. Three case vignettes illustrate situations in which military providers
      may find themselves stuck between incongruent ethical and legal demands. The
      authors conclude with several recommendations designed to prevent and resolve
      ethical-legal conflicts for military mental health providers.
FAU - Johnson, W Brad
AU  - Johnson WB
AD  - Department of Leadership, Ethics and Law, United States Naval Academy, Luce Hall,
      Stop 7B, Annapolis, MD 21402, USA.
FAU - Grasso, Ian
AU  - Grasso I
FAU - Maslowski, Kate
AU  - Maslowski K
LA  - eng
PT  - Journal Article
PL  - England
TA  - Mil Med
JT  - Military medicine
JID - 2984771R
SB  - IM
MH  - Codes of Ethics
MH  - Conflict, Psychological
MH  - Ethics, Professional
MH  - Humans
MH  - Mental Health Services/*ethics/*legislation & jurisprudence
MH  - Military Medicine/*ethics/*legislation & jurisprudence
MH  - Professional-Patient Relations
MH  - United States
EDAT- 2010/08/25 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/08/25 06:00
PHST- 2010/08/25 06:00 [entrez]
PHST- 2010/08/25 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - 10.7205/milmed-d-09-00119 [doi]
PST - ppublish
SO  - Mil Med. 2010 Aug;175(8):548-53. doi: 10.7205/milmed-d-09-00119.


PMID- 20731054
OWN - NLM
STAT- MEDLINE
DCOM- 20101203
LR  - 20191111
IS  - 1550-5014 (Electronic)
IS  - 0161-9268 (Linking)
VI  - 33
IP  - 3
DP  - 2010 Jul-Sep
TI  - The politics of nursing knowledge and education critical pedagogy in the face of 
      the militarization of nursing in the war on terror.
PG  - 184-95
AB  - This article critically examines the incursion of the military in nursing
      education, practice,and knowledge production. New funding programs, journals, and
      degrees in (bio)terrorism,emergency preparedness, and disaster management create 
      a context of uncertainty, fear, and crisis, and nursing is portrayed as ideally
      positioned to protect the wider public from adverse(health-related) events,
      despite important ontological, epistemological, and ethical considerations.In
      this article, we discuss implications for nursing education and knowledge
      production.We posit that a critical pedagogy framework promotes critical
      reflection, resistance, and a renewed sense of agency not dependent upon external
      organizations such as the military,intelligence agencies and public health
      surveillance organizations.
FAU - Perron, Amelie
AU  - Perron A
AD  - University of Ottawa, Ottawa, ON K1H 8M5,Canada. amelie.perron@uottawa.ca
FAU - Rudge, Trudy
AU  - Rudge T
FAU - Blais, Anne-Marie
AU  - Blais AM
FAU - Holmes, Dave
AU  - Holmes D
LA  - eng
PT  - Journal Article
PL  - United States
TA  - ANS Adv Nurs Sci
JT  - ANS. Advances in nursing science
JID - 7809992
SB  - IM
CIN - ANS Adv Nurs Sci. 2011 Jan-Mar;34(1):2-3; author reply 3-5. PMID: 21304279
CIN - ANS Adv Nurs Sci. 2011 Apr-Jun;34(2):92-3. PMID: 21728262
CIN - ANS Adv Nurs Sci. 2011 Apr-Jun;34(2):93-4. PMID: 21728263
CIN - ANS Adv Nurs Sci. 2011 Apr-Jun;34(2):94-6. PMID: 21728264
CIN - ANS Adv Nurs Sci. 2013 Jan-Mar;36(1):18-25. PMID: 23370497
MH  - Civil Defense/*education
MH  - Clinical Nursing Research
MH  - Disaster Planning/*organization & administration
MH  - Disasters
MH  - Education, Nursing/*organization & administration
MH  - Emergency Medicine/*education
MH  - Humans
MH  - Nurse's Role
MH  - Nursing Staff/*education
MH  - *Professional Competence
MH  - Public Health Nursing/education
MH  - Terrorism
MH  - Warfare
EDAT- 2010/08/24 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/24 06:00
PHST- 2010/08/24 06:00 [entrez]
PHST- 2010/08/24 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1097/ans.0b013e3181e093bc [doi]
PST - ppublish
SO  - ANS Adv Nurs Sci. 2010 Jul-Sep;33(3):184-95. doi: 10.1097/ans.0b013e3181e093bc.


PMID- 20730672
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20101207
IS  - 1536-7118 (Electronic)
IS  - 1536-710X (Linking)
VI  - 9
IP  - 2
DP  - 2010
TI  - Harm reduction in community mental health settings.
PG  - 130-47
LID - 10.1080/1536710X.2010.493481 [doi]
AB  - Harm reduction is a conceptual framework and set of practices that focus on the
      minimization of the physical, social, and legal harms substance users do to
      themselves and to society as a whole. Its application to community mental health 
      settings is relatively new, and can create controversies and ethical dilemmas if 
      not properly designed, implemented, and evaluated. Building on the harm reduction
      literature, the community mental health literature, and the authors' experiences 
      with a community mental health program that uses a harm reduction approach, the
      authors offer five guidelines for its successful implementation. The authors
      conclude that when properly integrated with other recovery-based services, and
      when appropriately applied to the individual client's stage of change, harm
      reduction can effectively be used, and should be used, in community mental health
      settings with clients with co-occurring substance use and psychiatric disorders.
FAU - Mancini, Michael A
AU  - Mancini MA
AD  - School of Social Work, Saint Louis University, St. Louis, Missouri 63103, USA.
      mancinim@slu.edu
FAU - Linhorst, Donald M
AU  - Linhorst DM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Soc Work Disabil Rehabil
JT  - Journal of social work in disability & rehabilitation
JID - 101132991
SB  - IM
MH  - Community Mental Health Services/*organization & administration
MH  - Decision Making
MH  - *Harm Reduction
MH  - Health Education/organization & administration
MH  - Homeless Persons
MH  - Housing
MH  - Humans
MH  - Mental Disorders/complications/*therapy
MH  - Social Work/*organization & administration
MH  - Substance-Related Disorders/complications/therapy
EDAT- 2010/08/24 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/24 06:00
PHST- 2010/08/24 06:00 [entrez]
PHST- 2010/08/24 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 925983282 [pii]
AID - 10.1080/1536710X.2010.493481 [doi]
PST - ppublish
SO  - J Soc Work Disabil Rehabil. 2010;9(2):130-47. doi: 10.1080/1536710X.2010.493481.


PMID- 20730670
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20101207
IS  - 1536-7118 (Electronic)
IS  - 1536-710X (Linking)
VI  - 9
IP  - 2
DP  - 2010
TI  - Ashley's case: the ethics of arresting the growth of children with serious
      disability.
PG  - 99-109
LID - 10.1080/1536710X.2010.493478 [doi]
AB  - This article analyzes the justifications and ethics of attenuating the growth of 
      children with serious disability. It considers the case of Ashley, a child with
      profound developmental and cognitive disabilities whose growth was attenuated
      through high-dose estrogen treatment and surgery. The goals of Ashley's parents
      and physicians were to keep her small, thereby making it easier for her parents
      to care for her at home. Perspectives supporting and opposing growth attenuation 
      are presented. It is suggested that community resources and supports, rather than
      medical strategies, are necessary to address the social challenges of community
      living.
FAU - Stein, Gary L
AU  - Stein GL
AD  - Wurzweiler School of Social Work, Yeshiva University, New York, New York 10033,
      USA. glstein@yu.edu
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Soc Work Disabil Rehabil
JT  - Journal of social work in disability & rehabilitation
JID - 101132991
RN  - 0 (Estrogens)
SB  - IM
MH  - Child
MH  - *Child Development
MH  - Developmental Disabilities/*therapy
MH  - *Disabled Children
MH  - Estrogens/therapeutic use
MH  - *Ethics, Medical
MH  - Female
MH  - Humans
MH  - Hysterectomy
MH  - Parents
EDAT- 2010/08/24 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/24 06:00
PHST- 2010/08/24 06:00 [entrez]
PHST- 2010/08/24 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 925982744 [pii]
AID - 10.1080/1536710X.2010.493478 [doi]
PST - ppublish
SO  - J Soc Work Disabil Rehabil. 2010;9(2):99-109. doi: 10.1080/1536710X.2010.493478.


PMID- 20730665
OWN - NLM
STAT- MEDLINE
DCOM- 20110624
LR  - 20220310
IS  - 1540-7586 (Electronic)
IS  - 0734-7332 (Linking)
VI  - 28
IP  - 5
DP  - 2010
TI  - Online support groups for women with metastatic breast cancer: a feasibility
      pilot study.
PG  - 560-86
LID - 10.1080/07347332.2010.504504 [doi]
AB  - This study evaluates the feasibility and acceptability of an online peer support 
      group intervention for women with metastatic breast cancer (MBC). Feasibility,
      participation rates, participant satisfaction, and preliminary outcomes are
      examined from a 1999 to 2000 study of online peer support groups for women with
      MBC. Thirty women with MBC were randomly assigned to either an immediate online
      support condition or a waitlisted control condition. For practical and ethical
      reasons, the waitlist period was limited to 2 months. Six monthly assessments
      were collected using standardized measurement instruments. Intervention retention
      rates (73%), assessment completion rates (range = 100%-86% in retained
      participants) and support group participation (M = 5.9 days per week) were high
      compared to other published studies on this population. Reported satisfaction
      with the intervention was also high. An online support intervention study is
      feasible using a waitlist control. Despite the feasibility and acceptability of
      the study procedures, the study design and small sample size precluded definitive
      conclusions about intervention effectiveness. As such, study procedures should be
      replicated with a larger more representative sample to examine the effectiveness 
      of the intervention.
FAU - Vilhauer, Ruvanee P
AU  - Vilhauer RP
AD  - Psychology Department, Felician College, Lodi, NJ 07644, USA.
      vilhauerr@felician.edu
FAU - McClintock, Martha K
AU  - McClintock MK
FAU - Matthews, Alicia K
AU  - Matthews AK
LA  - eng
GR  - R03 HS10565/HS/AHRQ HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Psychosoc Oncol
JT  - Journal of psychosocial oncology
JID - 8309337
SB  - IM
MH  - Adaptation, Psychological
MH  - Adult
MH  - Breast Neoplasms/*pathology/*psychology
MH  - Disease Progression
MH  - Feasibility Studies
MH  - Female
MH  - Health Services Accessibility
MH  - Humans
MH  - *Internet
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Patient Satisfaction
MH  - Peer Group
MH  - Pilot Projects
MH  - *Self-Help Groups
EDAT- 2010/08/24 06:00
MHDA- 2011/06/28 06:00
CRDT- 2010/08/24 06:00
PHST- 2010/08/24 06:00 [entrez]
PHST- 2010/08/24 06:00 [pubmed]
PHST- 2011/06/28 06:00 [medline]
AID - 926021902 [pii]
AID - 10.1080/07347332.2010.504504 [doi]
PST - ppublish
SO  - J Psychosoc Oncol. 2010;28(5):560-86. doi: 10.1080/07347332.2010.504504.


PMID- 20730595
OWN - NLM
STAT- MEDLINE
DCOM- 20110127
LR  - 20211020
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 22
IP  - 3
DP  - 2010 Sep
TI  - The lie of fMRI: an examination of the ethics of a market in lie detection using 
      functional magnetic resonance imaging.
PG  - 253-66
LID - 10.1007/s10730-010-9141-6 [doi]
AB  - In this paper, I argue that companies who use functional Magnetic Resonance
      Imaging (fMRI) scans for lie detection encounter the same basic ethical stumbling
      blocks as commercial companies that market traditional polygraphs. Markets in
      traditional voluntary polygraphs are common and fail to elicit much uproar among 
      ethicists. Thus, for consistency, if markets in polygraphs are ethically
      unproblematic, markets using fMRIs for lie detection are equally as acceptable.
      Furthermore, while I acknowledge two substantial differences between the ethical 
      concerns involving polygraphs and fMRI lie detection, I argue that these concerns
      can be overcome and do not lead to the conclusion that markets in fMRI lie
      detection are ethically dubious. It is my conclusion that voluntary markets in
      fMRI lie detection can be justified by consumer autonomy and should be allowed to
      persist.
FAU - White, Amy E
AU  - White AE
AD  - Department of Philosophy, Ohio University-Zanesville, 1425 Newark Road,
      Zanesville, OH 43701, USA. whitea@ohio.edu
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - Bioethics
MH  - Commerce/ethics
MH  - Humans
MH  - *Lie Detection
MH  - Magnetic Resonance Imaging/*ethics
EDAT- 2010/08/24 06:00
MHDA- 2011/01/29 06:00
CRDT- 2010/08/24 06:00
PHST- 2010/08/24 06:00 [entrez]
PHST- 2010/08/24 06:00 [pubmed]
PHST- 2011/01/29 06:00 [medline]
AID - 10.1007/s10730-010-9141-6 [doi]
PST - ppublish
SO  - HEC Forum. 2010 Sep;22(3):253-66. doi: 10.1007/s10730-010-9141-6.


PMID- 20730569
OWN - NLM
STAT- MEDLINE
DCOM- 20110701
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 16
IP  - 4
DP  - 2010 Dec
TI  - Generalizing on best practices in image processing: a model for promoting
      research integrity: Commentary on: Avoiding twisted pixels: ethical guidelines
      for the appropriate use and manipulation of scientific digital images.
PG  - 669-73
LID - 10.1007/s11948-010-9226-2 [doi]
AB  - Modifying images for scientific publication is now quick and easy due to changes 
      in technology. This has created a need for new image processing guidelines and
      attitudes, such as those offered to the research community by Doug Cromey (Cromey
      2010). We suggest that related changes in technology have simplified the task of 
      detecting misconduct for journal editors as well as researchers, and that this
      simplification has caused a shift in the responsibility for reporting misconduct.
      We also argue that the concept of best practices in image processing can serve as
      a general model for education in best practices in research.
FAU - Benos, Dale J
AU  - Benos DJ
AD  - Department of Physiology and Biophysics, University of Alabama at Birmingham,
      Birmingham, AL 35294-0005, USA. benos@uab.edu
FAU - Vollmer, Sara H
AU  - Vollmer SH
LA  - eng
PT  - Comment
PT  - Journal Article
DEP - 20100822
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
CON - Sci Eng Ethics. 2010 Dec;16(4):639-67. PMID: 20567932
MH  - Codes of Ethics
MH  - *Ethics, Research
MH  - Guidelines as Topic
MH  - Image Processing, Computer-Assisted/*ethics
MH  - Photography/*ethics
MH  - Science/*ethics
EDAT- 2010/08/24 06:00
MHDA- 2011/07/02 06:00
CRDT- 2010/08/24 06:00
PHST- 2009/09/14 00:00 [received]
PHST- 2010/07/06 00:00 [accepted]
PHST- 2010/08/24 06:00 [entrez]
PHST- 2010/08/24 06:00 [pubmed]
PHST- 2011/07/02 06:00 [medline]
AID - 10.1007/s11948-010-9226-2 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2010 Dec;16(4):669-73. doi: 10.1007/s11948-010-9226-2. Epub 2010 
      Aug 22.


PMID- 20730410
OWN - NLM
STAT- MEDLINE
DCOM- 20110119
LR  - 20100910
IS  - 1433-0385 (Electronic)
IS  - 0009-4722 (Linking)
VI  - 81
IP  - 9
DP  - 2010 Sep
TI  - [Ethical and legal prerequisites of living donors].
PG  - 787-90, 792-3
LID - 10.1007/s00104-009-1872-z [doi]
AB  - Patients in the waiting list die because there are too few postmortem organ
      donors. A way out of this dilemma would be living donors. The regulations on this
      in the transplantation act from 1997 are, however, very rudimentary and above all
      very restrictive. Furthermore, they have been partially superseded by medical
      advances. This leads to substantial insecurity for transplantation physicians in 
      the practice. This article examines the current law on living donors without
      being limited solely to it. Furthermore, attempts at reforms will be put forward.
FAU - Lilie, H
AU  - Lilie H
AD  - Lehrstuhl fur Strafrecht, Strafprozessrecht, Rechtsvergleichung und Medizinrecht,
      Juristische und Wirtschaftswissenschaftliche Fakultat, Martin-Luther-Universitat 
      Halle-Wittenberg, Halle, Saale, Deutschland. hans.lilie@jura.uni-halle.de
FAU - Kruger, M
AU  - Kruger M
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Ethische und rechtliche Voraussetzungen der Lebendspende.
PL  - Germany
TA  - Chirurg
JT  - Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
JID - 16140410R
SB  - IM
MH  - *Ethics, Medical
MH  - Germany
MH  - Health Care Reform
MH  - Humans
MH  - *Legislation, Medical
MH  - Living Donors/*ethics/*legislation & jurisprudence
MH  - *Waiting Lists
EDAT- 2010/08/24 06:00
MHDA- 2011/01/20 06:00
CRDT- 2010/08/24 06:00
PHST- 2010/08/24 06:00 [entrez]
PHST- 2010/08/24 06:00 [pubmed]
PHST- 2011/01/20 06:00 [medline]
AID - 10.1007/s00104-009-1872-z [doi]
PST - ppublish
SO  - Chirurg. 2010 Sep;81(9):787-90, 792-3. doi: 10.1007/s00104-009-1872-z.


PMID- 20730409
OWN - NLM
STAT- MEDLINE
DCOM- 20110119
LR  - 20211020
IS  - 1433-0385 (Electronic)
IS  - 0009-4722 (Linking)
VI  - 81
IP  - 9
DP  - 2010 Sep
TI  - [Psychosomatic aspects of living donor liver transplantation].
PG  - 820-5
LID - 10.1007/s00104-009-1876-8 [doi]
AB  - Living donor liver transplantation (LDLT) offers the option to reduce organ
      scarcity and thereby waiting list mortality. The crucial ethical problem of LDLT 
      is the fact that the well being of a donor is being jeopardized for the
      improvement of quality of life of the recipient. To preserve mental health of the
      donors, psychosomatic evaluation should be conducted including examination of the
      coping capacity, the mental stability of the donor and the voluntary nature of
      the donation. Thus a comprehensive disclosure of information to donors is
      necessary. Realistic outcome expectations, family relationships without extreme
      conflicts, sufficient autonomy of the donor-recipient relationship and social and
      familiar support are predictors facilitating a favorable psychosocial outcome for
      the donor. Before and after LDLT the health-related quality of life of the donors
      is similar or increased in comparison to the general population. Psychiatric
      complications following LDLT can occur in 13% of the donors. Female donors,
      donors who have surgical complications themselves and donors with unrealistic
      outcome expectations should be given psychotherapeutic support before they are
      admitted to living liver donation. Urgent indications in the case of acute liver 
      failure and the donation by adult children for their parents are particular
      stress factors. For the safety of the donor, these combinations should be avoided
      whenever possible.
FAU - Erim, Y
AU  - Erim Y
AD  - Klinik fur Psychosomatische Medizin und Psychotherapie, Universitatsklinikum
      Essen, Deutschland. yesim.erim@uni-essen.de
FAU - Beckmann, M
AU  - Beckmann M
FAU - Gerken, G
AU  - Gerken G
FAU - Paul, A
AU  - Paul A
FAU - Senf, W
AU  - Senf W
FAU - Beckebaum, S
AU  - Beckebaum S
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Psychosomatische Aspekte der Leberlebendspende.
PL  - Germany
TA  - Chirurg
JT  - Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
JID - 16140410R
SB  - IM
MH  - Adult
MH  - Child
MH  - Family
MH  - Female
MH  - Hepatectomy/*psychology
MH  - Humans
MH  - Liver Transplantation/*methods
MH  - Living Donors/*psychology/supply & distribution
MH  - Male
MH  - Mental Disorders/epidemiology/etiology
MH  - Parent-Child Relations
MH  - Psychotherapy
MH  - *Quality of Life
MH  - Social Support
MH  - Truth Disclosure
EDAT- 2010/08/24 06:00
MHDA- 2011/01/20 06:00
CRDT- 2010/08/24 06:00
PHST- 2010/08/24 06:00 [entrez]
PHST- 2010/08/24 06:00 [pubmed]
PHST- 2011/01/20 06:00 [medline]
AID - 10.1007/s00104-009-1876-8 [doi]
PST - ppublish
SO  - Chirurg. 2010 Sep;81(9):820-5. doi: 10.1007/s00104-009-1876-8.


PMID- 20730279
OWN - NLM
STAT- MEDLINE
DCOM- 20110114
LR  - 20190923
IS  - 1678-2925 (Electronic)
IS  - 0004-2749 (Linking)
VI  - 73
IP  - 3
DP  - 2010 May-Jun
TI  - [Trachoma in patients with allergic conjunctivitis].
PG  - 235-9
LID - S0004-27492010000300005 [pii]
AB  - PURPOSE: The aim of this paper was to identify a possible association between
      allergic conjunctivitis and Chlamydia trachomatis infection. METHODS: A
      prospective study was carried out in 104 eyes of 52 patients with diagnosis of
      vernal conjunctivitis and atopic keratoconjunctivitis. Conjunctival cytology was 
      performed in all the 52 patients, once it can evidence eosinophils presence and
      inclusions corpuscles in the conjunctival scraping smear, as well as the direct
      immunofluorescence that is the choice exam for Chlamydia trachomatis infection
      confirmation. All procedures were approved by the Institutional Review Board
      Ethics Committee. RESULTS: Of the 52 patients, 41 (78.8%) presented vernal
      conjunctivitis and 11 (21.2%) atopic keratoconjunctivitis. Forty-one patients
      (78.8%) were male and 11 (21.2%) female. The ages varied from 3 to 19 years, with
      an average of 9.8 years. Regarding racial distribution, 16 (30.8%) patients were 
      caucasian, 14 (26.9%) were black and 22 (42.3%) were brown. Regarding systemic
      allergic diseases, it was observed that 25 (48.1%) patients presented asthma, 20 
      (38.5%) allergic rhinitis and 5 (9.6%) atopic dermatitis. The main symptoms
      complained by the patients were coryza (59.6%), ocular itching (98.1%), burning
      (61.5%), tearing (65.3%) and photophobia (61.5%). The main clinical signs were:
      ocular hyperemia (100%), bilaterality (100%), superior tarsal papilla (92.3%) and
      mucous secretion (82.7%). The cytology of the conjunctival scrapings found
      eosinophil in 86.5% of the cases. Only seven patients did not present eosinophils
      in the conjunctival scrapings. Three patients (5.8%) presented positive
      immunofluorescence for Chlamydia, evidencing an association between allergic
      conjunctivitis and trachoma. CONCLUSION: It is important to determine the
      simultaneous coexistence of Chlamydia trachomatis and allergic conjunctivitis,
      due to the possibility to change the visual prognostic and of symptoms
      potentiation in case of double attack. Therefore, it is necessary to perform
      direct immunofluorescence for the correct diagnosis in patients with allergic
      conjunctivitis.
FAU - Bezerra, Haroldo de Lucena
AU  - Bezerra Hde L
AD  - Faculdade de Medicina Nova Esperanca, Joao Pessoa, PB, Brasil.
FAU - Santos, Glauco Igor Viana Dos
AU  - Santos GI
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Tracoma em pacientes com conjuntivite alergica.
PL  - Brazil
TA  - Arq Bras Oftalmol
JT  - Arquivos brasileiros de oftalmologia
JID - 0400645
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Chlamydia trachomatis/*isolation & purification
MH  - Conjunctivitis, Allergic/*complications/diagnosis
MH  - Female
MH  - Fluorescent Antibody Technique, Direct
MH  - Humans
MH  - Male
MH  - Prospective Studies
MH  - Trachoma/*complications/diagnosis
MH  - Young Adult
EDAT- 2010/08/24 06:00
MHDA- 2011/01/15 06:00
CRDT- 2010/08/24 06:00
PHST- 2009/09/28 00:00 [received]
PHST- 2010/06/07 00:00 [accepted]
PHST- 2010/08/24 06:00 [entrez]
PHST- 2010/08/24 06:00 [pubmed]
PHST- 2011/01/15 06:00 [medline]
AID - S0004-27492010000300005 [pii]
AID - 10.1590/s0004-27492010000300005 [doi]
PST - ppublish
SO  - Arq Bras Oftalmol. 2010 May-Jun;73(3):235-9. doi:
      10.1590/s0004-27492010000300005.


PMID- 20730275
OWN - NLM
STAT- MEDLINE
DCOM- 20110114
LR  - 20190923
IS  - 1678-2925 (Electronic)
IS  - 0004-2749 (Linking)
VI  - 73
IP  - 3
DP  - 2010 May-Jun
TI  - [Ethics in scientific publication: an everyday work--the search for an absolute
      value in a relativized world].
PG  - 217-8
LID - S0004-27492010000300001 [pii]
FAU - Rocha, Eduardo M
AU  - Rocha EM
LA  - por
PT  - Editorial
TT  - Etica em publicacoes cientificas: um trabalho de todo dia--a busca do valor
      absoluto no mundo relativizado.
PL  - Brazil
TA  - Arq Bras Oftalmol
JT  - Arquivos brasileiros de oftalmologia
JID - 0400645
SB  - IM
MH  - Animals
MH  - Codes of Ethics
MH  - *Ethics, Research
MH  - Humans
MH  - Periodicals as Topic/*ethics
EDAT- 2010/08/24 06:00
MHDA- 2011/01/15 06:00
CRDT- 2010/08/24 06:00
PHST- 2010/08/24 06:00 [entrez]
PHST- 2010/08/24 06:00 [pubmed]
PHST- 2011/01/15 06:00 [medline]
AID - S0004-27492010000300001 [pii]
AID - 10.1590/s0004-27492010000300001 [doi]
PST - ppublish
SO  - Arq Bras Oftalmol. 2010 May-Jun;73(3):217-8. doi:
      10.1590/s0004-27492010000300001.


PMID- 20730106
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 1176-7529 (Print)
IS  - 1176-7529 (Linking)
VI  - 7
IP  - 3
DP  - 2010 Sep
TI  - The Nobel Prize as a Reward Mechanism in the Genomics Era: Anonymous Researchers,
      Visible Managers and the Ethics of Excellence.
PG  - 299-312
AB  - The Human Genome Project (HGP) is regarded by many as one of the major scientific
      achievements in recent science history, a large-scale endeavour that is changing 
      the way in which biomedical research is done and expected, moreover, to yield
      considerable benefit for society. Thus, since the completion of the human genome 
      sequencing effort, a debate has emerged over the question whether this effort
      merits to be awarded a Nobel Prize and if so, who should be the one(s) to receive
      it, as (according to current procedures) no more than three individuals can be
      selected. In this article, the HGP is taken as a case study to consider the
      ethical question to what extent it is still possible, in an era of big science,
      of large-scale consortia and global team work, to acknowledge and reward
      individual contributions to important breakthroughs in biomedical fields. Is it
      still viable to single out individuals for their decisive contributions in order 
      to reward them in a fair and convincing way? Whereas the concept of the Nobel
      prize as such seems to reflect an archetypical view of scientists as solitary
      researchers who, at a certain point in their careers, make their one decisive
      discovery, this vision has proven to be problematic from the very outset. Already
      during the first decade of the Nobel era, Ivan Pavlov was denied the Prize
      several times before finally receiving it, on the basis of the argument that he
      had been active as a research manager (a designer and supervisor of research
      projects) rather than as a researcher himself. The question then is whether, in
      the case of the HGP, a research effort that involved the contributions of
      hundreds or even thousands of researchers worldwide, it is still possible to
      "individualise" the Prize? The "HGP Nobel Prize problem" is regarded as an
      exemplary issue in current research ethics, highlighting a number of quandaries
      and trends involved in contemporary life science research practices more broadly.
FAU - Zwart, Hub
AU  - Zwart H
AD  - Faculty of Science, Radboud University Nijmegen, Department of Philosophy &
      Science Studies, Centre for Society & Genomics Institute for Science, Innovation 
      & Society, P.O. Box 9010, 6500 GL Nijmegen, The Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20100709
PL  - Netherlands
TA  - J Bioeth Inq
JT  - Journal of bioethical inquiry
JID - 101250741
PMC - PMC2917546
EDAT- 2010/08/24 06:00
MHDA- 2010/08/24 06:01
CRDT- 2010/08/24 06:00
PHST- 2009/03/29 00:00 [received]
PHST- 2010/05/26 00:00 [accepted]
PHST- 2010/08/24 06:00 [entrez]
PHST- 2010/08/24 06:00 [pubmed]
PHST- 2010/08/24 06:01 [medline]
AID - 10.1007/s11673-010-9248-0 [doi]
PST - ppublish
SO  - J Bioeth Inq. 2010 Sep;7(3):299-312. doi: 10.1007/s11673-010-9248-0. Epub 2010
      Jul 9.


PMID- 20729502
OWN - NLM
STAT- MEDLINE
DCOM- 20110317
LR  - 20211203
IS  - 1049-7323 (Print)
IS  - 1049-7323 (Linking)
VI  - 20
IP  - 12
DP  - 2010 Dec
TI  - "You know what I mean:" the ethical and methodological dilemmas and challenges
      for black researchers interviewing black families.
PG  - 1725-35
LID - 10.1177/1049732310381085 [doi]
AB  - In this article I provide a reflexive account of my research experiences with
      families of African descent. I examine the ways in which, as a researcher of
      African descent, I became part of the research process. Using data from an
      ethnographic study that explored the healthy lifestyle experiences and attitudes 
      of families and adolescents of African descent in the northwest of England, I
      present a detailed discussion of the identity alteration, researcher-researched
      relationships, and insider-outsider tensions and dilemmas that arose while I
      collected data. I argue that researchers working with participants with whom they
      share similar ethnicity and historical experiences are likely to find that their 
      professional self and personal life experiences overlap, and there can be
      difficulties in keeping them separate.
FAU - Ochieng, Bertha M N
AU  - Ochieng BM
AD  - School of Health Studies, University of Bradford, Bradford, West Yorkshire,
      United Kingdom. b.ochieng@bradford.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20100820
PL  - United States
TA  - Qual Health Res
JT  - Qualitative health research
JID - 9202144
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Anthropology, Cultural/*ethics/*methods
MH  - Blacks/*ethnology
MH  - Child
MH  - England
MH  - Female
MH  - Humans
MH  - Interviews as Topic/*methods
MH  - Life Style
MH  - Male
MH  - Middle Aged
MH  - Nuclear Family/psychology
MH  - Parent-Child Relations
MH  - Researcher-Subject Relations/*ethics
MH  - *Social Identification
EDAT- 2010/08/24 06:00
MHDA- 2011/03/18 06:00
CRDT- 2010/08/24 06:00
PHST- 2010/08/24 06:00 [entrez]
PHST- 2010/08/24 06:00 [pubmed]
PHST- 2011/03/18 06:00 [medline]
AID - 1049732310381085 [pii]
AID - 10.1177/1049732310381085 [doi]
PST - ppublish
SO  - Qual Health Res. 2010 Dec;20(12):1725-35. doi: 10.1177/1049732310381085. Epub
      2010 Aug 20.


PMID- 20729252
OWN - NLM
STAT- MEDLINE
DCOM- 20110405
LR  - 20211028
IS  - 1740-7753 (Electronic)
IS  - 1740-7745 (Linking)
VI  - 7
IP  - 6
DP  - 2010 Dec
TI  - Regulatory impediments jeopardizing the conduct of clinical trials in Europe
      funded by the National Institutes of Health.
PG  - 705-18
LID - 10.1177/1740774510376547 [doi]
AB  - BACKGROUND: A number of reports have highlighted problems of conducting publicly 
      funded trials in Europe as a consequence of the European Union (EU) Clinical
      Trials Directive. The impact of the EU Directive on multi-national trials, which 
      include sites in Europe that are funded by the US National Institutes of Health
      (NIH) have not been described. METHODS: Four problems in the conduct of two
      international HIV treatment trials funded by NIH in the EU are described: (1)
      conflicting regulations on the continuing review of protocols by Institutional
      Review Boards/Research Ethics Committees; (2) US regulations requiring
      Federalwide Assurances for sites which are only partially funded by NIH; (3) EU
      guidance on the designation of studies as a trial of an investigational medicinal
      product; and (4) EU guidance on trial sponsorship and the requirements for
      insurance and indemnification. Following the description of the problems,
      recommendations for improving global collaborations are made to the US Office of 
      Human Research Protections, to NIH, and to the EU and its Member States. RESULTS:
      A lack of harmonization of regulations at multiple levels caused enrollment in
      one study to be interrupted for several months and delayed for one year the
      initiation of another study aimed at obtaining definitive evidence to guide the
      timing of the initiation of antiretroviral therapy for individuals infected with 
      HIV. The delays and the purchase of insurance resulted in substantial increases
      in trial costs and caused substantial disruption at clinical sites among staff
      and study participants. LIMITATIONS: The problems cited and recommendations made 
      pertain to trials funded by NIH and conducted by sites in the EU. There are many 
      other challenges in the conduct of international research, public and private,
      that global harmonization would alleviate. CONCLUSIONS: Disharmony, at multiple
      levels, in international regulations and guidelines is stifling publicly funded
      global research. International scientific organizations and government groups
      should make the documentation and solution of these problems a priority.
FAU - Neaton, James D
AU  - Neaton JD
AD  - Division of Biostatistics, School of Public Health, University of Minnesota,
      Minneapolis, MN 55414, USA. jim@ccbr.umn.edu
FAU - Babiker, Abdel
AU  - Babiker A
FAU - Bohnhorst, Mark
AU  - Bohnhorst M
FAU - Darbyshire, Janet
AU  - Darbyshire J
FAU - Denning, Eileen
AU  - Denning E
FAU - Frishman, Arnie
AU  - Frishman A
FAU - Grarup, Jesper
AU  - Grarup J
FAU - Larson, Gregg
AU  - Larson G
FAU - Lundgren, Jens
AU  - Lundgren J
LA  - eng
GR  - MC_U122886352/MRC_/Medical Research Council/United Kingdom
GR  - U01 AI068641/AI/NIAID NIH HHS/United States
GR  - U01 AI068641-05/AI/NIAID NIH HHS/United States
GR  - U01-AI068641/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100820
PL  - England
TA  - Clin Trials
JT  - Clinical trials (London, England)
JID - 101197451
RN  - 0 (Anti-HIV Agents)
SB  - IM
CIN - Clin Trials. 2010 Dec;7(6):621. PMID: 21138919
CIN - Clin Trials. 2010 Dec;7(6):622-5. PMID: 21138920
MH  - Anti-HIV Agents/therapeutic use
MH  - *Clinical Protocols
MH  - Clinical Trials as Topic/*legislation & jurisprudence/methods/standards
MH  - Drug and Narcotic Control/economics/*legislation & jurisprudence
MH  - Europe
MH  - European Union
MH  - *Government Regulation
MH  - Guideline Adherence
MH  - Guidelines as Topic
MH  - HIV Infections/drug therapy
MH  - Humans
MH  - Internationality
MH  - Multicenter Studies as Topic
MH  - National Institutes of Health (U.S.)
MH  - United States
PMC - PMC3108098
MID - NIHMS294959
EDAT- 2010/08/24 06:00
MHDA- 2011/04/06 06:00
CRDT- 2010/08/24 06:00
PHST- 2010/08/24 06:00 [entrez]
PHST- 2010/08/24 06:00 [pubmed]
PHST- 2011/04/06 06:00 [medline]
AID - 1740774510376547 [pii]
AID - 10.1177/1740774510376547 [doi]
PST - ppublish
SO  - Clin Trials. 2010 Dec;7(6):705-18. doi: 10.1177/1740774510376547. Epub 2010 Aug
      20.


PMID- 20729251
OWN - NLM
STAT- MEDLINE
DCOM- 20110405
LR  - 20220317
IS  - 1740-7753 (Electronic)
IS  - 1740-7745 (Linking)
VI  - 7
IP  - 6
DP  - 2010 Dec
TI  - Successful clinical trial research in nursing homes: the Improving
      Decision-Making Study.
PG  - 735-43
LID - 10.1177/1740774510380241 [doi]
AB  - BACKGROUND: One in four Americans, and 70% of people who have dementia, will
      spend their final days in nursing home care. Clinical research, particularly
      clinical trials, rarely includes this population due to unique challenges in
      research methods and ethics. Families of advanced dementia patients make choices 
      about tube feeding and other feeding options with limited access to information
      or communication. The cluster randomized trial, Improving Decision Making about
      Feeding Options for Dementia Patients, tests a decision aid intervention to
      improve the quality of decision making for this choice. PURPOSE: Our objectives
      are (1) to describe the methods used in this trial; (2) to describe challenges
      and strategies for effective nursing home and nursing home resident recruitment
      and retention; and (3) to describe research ethics approaches to minimize harms
      and maximize benefits for this population. METHODS: The study is a cluster
      randomized trial of a decision aid to inform and support the choice between tube 
      feeding and assisted oral feeding in advanced dementia. Study subjects are paired
      surrogate decision makers and residents with advanced dementia and feeding
      problems, enrolled from nursing homes in North Carolina. RESULTS: This trial
      enrolled 256 paired surrogate decision makers and residents in 24 nursing home
      sites, and 99% completed participation through the 3-month study period. The
      research team had prior clinical and investigative experience in this setting,
      and used multiple strategies to recruit and retain nursing home sites, providers,
      surrogates, and the residents for whom they spoke. Informed consent and human
      subjects' protections were designed to address the vulnerability of this
      population. LIMITATIONS: Cluster randomization was necessary to avoid
      contamination between control and intervention subjects, but may introduce
      confounding by site and intracluster correlation effects in analyses.
      CONCLUSIONS: Strategies that facilitate nursing home recruitment, participant
      recruitment and protection of human subjects for a vulnerable population may be
      used by future investigators to expand the research evidence base for nursing
      home and dementia care.
FAU - Hanson, Laura C
AU  - Hanson LC
AD  - Division of Geriatric Medicine and Palliative Care Program, University of North
      Carolina, Chapel Hill, NC 27599-7550, USA. lhanson@med.unc.edu
FAU - Gilliam, Robin
AU  - Gilliam R
FAU - Lee, Tae Joon
AU  - Lee TJ
LA  - eng
SI  - ClinicalTrials.gov/NCT01113749
GR  - R01 NR009826/NR/NINR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100820
PL  - England
TA  - Clin Trials
JT  - Clinical trials (London, England)
JID - 101197451
SB  - IM
MH  - Aged
MH  - Biomedical Research/*methods/standards
MH  - Clinical Trials as Topic/*methods/standards
MH  - *Cluster Analysis
MH  - *Decision Making
MH  - Decision Support Techniques
MH  - Dementia/complications
MH  - Enteral Nutrition
MH  - Feeding Behavior
MH  - Female
MH  - Humans
MH  - Male
MH  - North Carolina
MH  - Nursing Homes/*statistics & numerical data
MH  - Patient Selection
MH  - Psychometrics
MH  - United States
PMC - PMC4384049
MID - NIHMS674894
EDAT- 2010/08/24 06:00
MHDA- 2011/04/06 06:00
CRDT- 2010/08/24 06:00
PHST- 2010/08/24 06:00 [entrez]
PHST- 2010/08/24 06:00 [pubmed]
PHST- 2011/04/06 06:00 [medline]
AID - 1740774510380241 [pii]
AID - 10.1177/1740774510380241 [doi]
PST - ppublish
SO  - Clin Trials. 2010 Dec;7(6):735-43. doi: 10.1177/1740774510380241. Epub 2010 Aug
      20.


PMID- 20729222
OWN - NLM
STAT- MEDLINE
DCOM- 20110225
LR  - 20101101
IS  - 1469-0756 (Electronic)
IS  - 0032-5473 (Linking)
VI  - 86
IP  - 1021
DP  - 2010 Nov
TI  - A day in the life of a junior doctor: everyday ethical encounters.
PG  - 632-5
LID - 10.1136/pgmj.2008.077388 [doi]
AB  - This paper presents a hypothetical 'day in the life' of junior doctors working on
      a busy hospital ward. It illustrates the fact that, although the everyday ethical
      encounters faced by doctors are generally not as dramatic as some of the ethical 
      issues discussed at medical school, the underlying principles, such as consent,
      confidentiality and resource allocation, are highly relevant to daily practice.
      After presenting some of the ethical challenges faced by junior doctors, from
      patients confused by poor explanations to inadequate consent procedures, the
      paper ends with suggestions on how to improve the situation.
FAU - Quarini, Catherine J
AU  - Quarini CJ
AD  - catherinequarini@doctors.org.uk
LA  - eng
PT  - Journal Article
DEP - 20100820
PL  - England
TA  - Postgrad Med J
JT  - Postgraduate medical journal
JID - 0234135
SB  - IM
CIN - Postgrad Med J. 2010 Nov;86(1021):629-30. PMID: 21037236
CIN - Postgrad Med J. 2010 Nov;86(1021):631. PMID: 21037237
MH  - *Ethics, Medical
MH  - Humans
MH  - Informed Consent/ethics
MH  - Medical Staff, Hospital/*ethics
MH  - Professional Practice/ethics
MH  - Truth Disclosure/ethics
EDAT- 2010/08/24 06:00
MHDA- 2011/02/26 06:00
CRDT- 2010/08/24 06:00
PHST- 2010/08/24 06:00 [entrez]
PHST- 2010/08/24 06:00 [pubmed]
PHST- 2011/02/26 06:00 [medline]
AID - pgmj.2008.077388 [pii]
AID - 10.1136/pgmj.2008.077388 [doi]
PST - ppublish
SO  - Postgrad Med J. 2010 Nov;86(1021):632-5. doi: 10.1136/pgmj.2008.077388. Epub 2010
      Aug 20.


PMID- 20729184
OWN - NLM
STAT- MEDLINE
DCOM- 20110208
LR  - 20220408
IS  - 0250-832X (Print)
IS  - 0250-832X (Linking)
VI  - 39
IP  - 6
DP  - 2010 Sep
TI  - Diagnosing common parotid tumours with magnetic resonance imaging including
      diffusion-weighted imaging vs fine-needle aspiration cytology: a comparative
      study.
PG  - 349-55
LID - 10.1259/dmfr/15047967 [doi]
AB  - OBJECTIVES: the purpose of this study was to evaluate the accuracy of MRI
      combined with diffusion-weighted imaging (DWI) vs fine-needle aspiration cytology
      (FNAC) in diagnosing common parotid masses. METHODS: 25 consecutive patients
      (mean age 61 years) with parotid masses were included in this study. Informed
      consent and ethical approval was obtained. 22 patients underwent both MRI
      combined with DWI and FNAC. From DWI data, apparent diffusion coefficient maps
      were generated. The MRI study protocol consisted of T(1) weighted spin echo; T(2)
      weighted and T(2) weighted fat-suppressed turbo spin echo; DWI; and T(1) weighted
      fat-suppressed post-contrast images. MRI and FNAC diagnoses were compared with
      histopathology. Youden's index was used to compare the two methods. RESULTS:
      masses comprised eight Warthin tumours, eight adenomas (six pleomorphic adenomas,
      two basal cell adenomas), five carcinomas, two lipomas, one haemagioma and one
      benign lymphadenopathy. Technically, MRI was successful in 24 of the 25 patients 
      (96%), FNAC was successful in 20 of the 23 patients (87.0%). The accuracy,
      sensitivity and specificity of MRI without DWI were 96%, 80% and 100%,
      respectively. Diagnostic accuracy did not increase by adding DWI to conventional 
      MRI; however, DWI was helpful for diagnosing benign tumour histology. MRI
      combined with DWI was successful for determining accurate tumour typing in all
      benign masses except one lymphadenopathy. When FNAC had adequate material the
      accuracy, sensitivity and specificity were 95%, 75% and 100%, respectively.
      Youden's index was 0.80 for MRI and 0.75 for FNAC. CONCLUSIONS: MRI combined with
      DWI seems to have similar diagnostic potential as FNAC in differentiation of
      benign vs malignant parotid masses.
FAU - Yerli, H
AU  - Yerli H
AD  - Baskent University Faculty of Medicine, Department of Radiology, Ankara, Turkey, 
      35590. hasanyerli@yahoo.com
FAU - Aydin, E
AU  - Aydin E
FAU - Haberal, N
AU  - Haberal N
FAU - Harman, A
AU  - Harman A
FAU - Kaskati, T
AU  - Kaskati T
FAU - Alibek, S
AU  - Alibek S
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PL  - England
TA  - Dentomaxillofac Radiol
JT  - Dento maxillo facial radiology
JID - 7609576
MH  - Adenolymphoma/*pathology
MH  - Adenoma/*pathology
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Biopsy, Fine-Needle
MH  - Carcinoma/*pathology
MH  - *Diffusion Magnetic Resonance Imaging
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Parotid Neoplasms/*pathology
MH  - Sensitivity and Specificity
MH  - Statistics, Nonparametric
PMC - PMC3520240
EDAT- 2010/08/24 06:00
MHDA- 2011/02/09 06:00
CRDT- 2010/08/24 06:00
PHST- 2010/08/24 06:00 [entrez]
PHST- 2010/08/24 06:00 [pubmed]
PHST- 2011/02/09 06:00 [medline]
AID - 39/6/349 [pii]
AID - 10.1259/dmfr/15047967 [doi]
PST - ppublish
SO  - Dentomaxillofac Radiol. 2010 Sep;39(6):349-55. doi: 10.1259/dmfr/15047967.


PMID- 20728969
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20151119
IS  - 1532-1940 (Electronic)
IS  - 0266-4356 (Linking)
VI  - 49
IP  - 6
DP  - 2011 Sep
TI  - Reducing postoperative pain by changing the process.
PG  - 459-63
LID - 10.1016/j.bjoms.2010.07.012 [doi]
AB  - Untreated postoperative pain is an important ethical and financial issue that can
      lead to unnecessary suffering and prolonged stays in hospital. Despite the
      availability of effective analgesics and a growing body of published material
      that supports their use, postoperative pain remains a problem worldwide. To
      reduce acute postoperative pain, we introduced an intervention combining
      evidence-based analgesic protocols with the education of staff and patients on a 
      surgical ward. The experiences of 68 patients before and 80 patients after the
      intervention were compared (worst pain scores, duration of pain, and
      satisfaction). Inadequately controlled pain was significantly reduced after the
      intervention, which suggests that the introduction of analgesic protocols
      supported by the education of staff and patients can be beneficial. Despite this,
      severe pain remained relatively common, indicating room for improvement. Duration
      of pain and patient satisfaction were not affected by the intervention, and
      patient satisfaction remained high throughout the study.
CI  - Copyright (c) 2010 British Association of Oral and Maxillofacial Surgeons.
      Published by Elsevier Ltd. All rights reserved.
FAU - Crawford, F I J
AU  - Crawford FI
AD  - School of Dentistry, The University of Manchester, Manchester Academic Health
      Science Centre, University Dental Hospital of Manchester, Higher Cambridge
      Street, Manchester, M15 6FH, UK.
FAU - Armstrong, D
AU  - Armstrong D
FAU - Boardman, C
AU  - Boardman C
FAU - Coulthard, P
AU  - Coulthard P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100821
PL  - Scotland
TA  - Br J Oral Maxillofac Surg
JT  - The British journal of oral & maxillofacial surgery
JID - 8405235
RN  - 0 (Analgesics)
RN  - 0 (Analgesics, Non-Narcotic)
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 362O9ITL9D (Acetaminophen)
RN  - 39J1LGJ30J (Tramadol)
RN  - WK2XYI10QM (Ibuprofen)
SB  - IM
MH  - Acetaminophen/therapeutic use
MH  - Acute Pain/prevention & control
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Analgesics/*therapeutic use
MH  - Analgesics, Non-Narcotic/therapeutic use
MH  - Analgesics, Opioid/therapeutic use
MH  - Anti-Inflammatory Agents, Non-Steroidal/therapeutic use
MH  - Clinical Protocols
MH  - Dental Staff, Hospital/education
MH  - Evidence-Based Dentistry
MH  - Female
MH  - Humans
MH  - Ibuprofen/therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Nursing Staff, Hospital/education
MH  - Oral Surgical Procedures
MH  - Pain Measurement
MH  - Pain, Postoperative/*prevention & control
MH  - Patient Education as Topic
MH  - Patient Satisfaction
MH  - Tramadol/therapeutic use
MH  - Young Adult
EDAT- 2010/08/24 06:00
MHDA- 2012/01/27 06:00
CRDT- 2010/08/24 06:00
PHST- 2009/11/17 00:00 [received]
PHST- 2010/07/23 00:00 [accepted]
PHST- 2010/08/24 06:00 [entrez]
PHST- 2010/08/24 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - S0266-4356(10)00233-0 [pii]
AID - 10.1016/j.bjoms.2010.07.012 [doi]
PST - ppublish
SO  - Br J Oral Maxillofac Surg. 2011 Sep;49(6):459-63. doi:
      10.1016/j.bjoms.2010.07.012. Epub 2010 Aug 21.


PMID- 20728632
OWN - NLM
STAT- MEDLINE
DCOM- 20101216
LR  - 20141120
IS  - 1879-2057 (Electronic)
IS  - 0001-4575 (Linking)
VI  - 42
IP  - 6
DP  - 2010 Nov
TI  - Preferences for lives, injuries, and age: a stated preference survey.
PG  - 1814-21
LID - 10.1016/j.aap.2010.05.002 [doi]
AB  - One of the more difficult ethical questions from a public decision-making
      perspective is whether the estimation of benefits from risk reducing projects
      should be influenced by factors such as age groups and risk domains. For example,
      should a project that saves the lives of elderly people be assigned a more
      different benefit value in cost-benefit analyses than one that saves the same
      number of children's lives? This paper examines the preferences of the general
      public in Sweden on these issues. We design a choice experiment in which subjects
      are required to make six pair-wise choices where the characteristics of each
      choice are accident type (fire and traffic), number of fatalities and serious
      injuries avoided, and age of those saved (5-15-, 35-45- and 65-75-year-olds). We 
      find that avoiding the fatality of one 5-15-year-old is equivalent to avoiding
      1.4 fatalities of 35-45-year-olds. Likewise, avoiding the fatality of one
      5-15-year-old is equivalent to avoiding 3.3 fatalities of 65-75-year-olds. We
      find no significant differences between the causes of accident. One avoided
      fatality is found to be equivalent to around 3.5 avoided severe injuries, which
      is lower than the official value of 6 used by the Swedish Road Administration.
CI  - 2010 Elsevier Ltd. All rights reserved.
FAU - Carlsson, Fredrik
AU  - Carlsson F
AD  - Department of Economics, Goteborg University, Box 640, SE-40530 Goteborg, Sweden.
      Fredrik.Carlsson@economics.gu.se
FAU - Daruvala, Dinky
AU  - Daruvala D
FAU - Jaldell, Henrik
AU  - Jaldell H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100531
PL  - England
TA  - Accid Anal Prev
JT  - Accident; analysis and prevention
JID - 1254476
SB  - IM
MH  - Accidents, Traffic/economics/mortality/*prevention & control
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Child
MH  - Child, Preschool
MH  - City Planning/economics/*ethics
MH  - Consumer Behavior/*economics
MH  - Cost-Benefit Analysis
MH  - Data Collection
MH  - Decision Making/*ethics
MH  - *Environment Design/economics
MH  - Female
MH  - Fires/economics/*prevention & control/statistics & numerical data
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Risk Reduction Behavior
MH  - Sweden
MH  - Wounds and Injuries/economics/mortality/*prevention & control
MH  - Young Adult
EDAT- 2010/08/24 06:00
MHDA- 2010/12/17 06:00
CRDT- 2010/08/24 06:00
PHST- 2009/12/21 00:00 [received]
PHST- 2010/04/28 00:00 [revised]
PHST- 2010/05/04 00:00 [accepted]
PHST- 2010/08/24 06:00 [entrez]
PHST- 2010/08/24 06:00 [pubmed]
PHST- 2010/12/17 06:00 [medline]
AID - S0001-4575(10)00138-7 [pii]
AID - 10.1016/j.aap.2010.05.002 [doi]
PST - ppublish
SO  - Accid Anal Prev. 2010 Nov;42(6):1814-21. doi: 10.1016/j.aap.2010.05.002. Epub
      2010 May 31.


PMID- 20728583
OWN - NLM
STAT- MEDLINE
DCOM- 20110316
LR  - 20101124
IS  - 1873-0183 (Electronic)
IS  - 1568-9972 (Linking)
VI  - 10
IP  - 2
DP  - 2010 Dec
TI  - Human cord blood stem cells and the journey to a cure for type 1 diabetes.
PG  - 103-7
LID - 10.1016/j.autrev.2010.08.011 [doi]
AB  - Umbilical cord blood contains several types of stem cells that are of interest to
      a wide range of disciplines in regenerative medicine. The translational potential
      to the clinical applications of cord blood stem cells has increased enormously in
      recent years, mainly because of its advantages including no risk to the donor, no
      ethical issues, low risk of graft-versus-host disease (GVHD) and rapid
      availability. Type 1 diabetes (T1D) is an autoimmune disease caused by an
      autoimmune destruction of pancreatic islet beta cells. Understanding the nature
      and function of cord blood stem cells is an exciting challenge that might set the
      stage for new approaches to the treatment of T1D. Here, we review progress in
      this field and draw conclusions for the development of future therapeutics in
      T1D. New insights are provided on a unique type of cord blood-derived multipotent
      stem cells (CB-SC), including the molecular mechanisms underlying immune
      modulation by CB-SC, protection of beta-cell mass, and promotion of islet
      beta-cell neogenesis.
CI  - Copyright (c) 2010 Elsevier B.V. All rights reserved.
FAU - Zhao, Yong
AU  - Zhao Y
AD  - Section of Endocrinology, Diabetes & Metabolism, Department of Medicine,
      University of Illinois at Chicago, Chicago, IL 60612, USA. yongzhao@uic.edu
FAU - Mazzone, Theodore
AU  - Mazzone T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100820
PL  - Netherlands
TA  - Autoimmun Rev
JT  - Autoimmunity reviews
JID - 101128967
SB  - IM
MH  - Cord Blood Stem Cell Transplantation/*methods
MH  - Diabetes Mellitus, Type 1/immunology/*therapy
MH  - Fetal Blood/cytology/immunology
MH  - Humans
MH  - Islets of Langerhans/cytology/*growth & development
MH  - Regenerative Medicine/methods
MH  - Stem Cells/cytology/immunology
EDAT- 2010/08/24 06:00
MHDA- 2011/03/17 06:00
CRDT- 2010/08/24 06:00
PHST- 2010/08/12 00:00 [received]
PHST- 2010/08/15 00:00 [accepted]
PHST- 2010/08/24 06:00 [entrez]
PHST- 2010/08/24 06:00 [pubmed]
PHST- 2011/03/17 06:00 [medline]
AID - S1568-9972(10)00179-5 [pii]
AID - 10.1016/j.autrev.2010.08.011 [doi]
PST - ppublish
SO  - Autoimmun Rev. 2010 Dec;10(2):103-7. doi: 10.1016/j.autrev.2010.08.011. Epub 2010
      Aug 20.


PMID- 20727645
OWN - NLM
STAT- MEDLINE
DCOM- 20101208
LR  - 20120105
IS  - 1531-5053 (Electronic)
IS  - 0278-2391 (Linking)
VI  - 68
IP  - 11
DP  - 2010 Nov
TI  - Microsurgical repair of the peripheral trigeminal nerve after mandibular sagittal
      split ramus osteotomy.
PG  - 2770-82
LID - 10.1016/j.joms.2010.05.065 [doi]
AB  - PURPOSE: Injuries to the inferior alveolar nerve (IAN) and lingual nerves (LNs)
      have long been known complications of the mandibular sagittal split ramus
      osteotomy (SSRO). Most postoperative paresthesias resolve without treatment.
      However, microsurgical exploration of the nerve may be indicated in cases of
      significant persistent sensory dysfunction associated with observed or suspected 
      localized IAN or LN injury. We report the demographics and outcome of
      microsurgical exploration and repair of peripheral branches of the trigeminal
      nerve injured because of the SSRO. MATERIALS AND METHODS: A retrospective chart
      review was completed on all patients who had microsurgical repair of peripheral
      trigeminal nerve injuries caused by mandibular SSRO and were operated on by the
      senior author (R.A.M.) between March 1986 and December 2005. A physical
      examination, including standardized neurosensory testing (NST) as described by
      Zuniga et al, was completed on each patient preoperatively. All patients were
      followed periodically after surgery for at least 1 year with NST repeated at each
      visit. NST results obtained at the last patient visit were used to determine the 
      final level of recovery of sensory function. Sensory recovery was evaluated using
      guidelines established by the Medical Research Council scale. The following data 
      were collected and analyzed: age of patient, gender, nerve injured, chief sensory
      complaint (numbness, pain, or both), duration (months) from injury to surgical
      intervention, intraoperative findings, surgical procedure, and neurosensory
      status at final evaluation. Given the retrospective nature of this study, the
      research was exempt from our institutional review board ethics committee.
      RESULTS: There were 54 (n = 54) patients (8 males and 46 females) with an average
      age of 36.9 years (range, 16 to 55 years) and a follow-up of at least 12 months. 
      The most commonly injured/repaired nerve was the IAN (n = 39), followed by the LN
      (n = 14), and the long buccal nerve (n = 1). In 31 patients (57.4%), the chief
      sensory complaint was numbness, while 20 patients (37%) complained of pain and
      numbness, and 3 patients (5.5%) complained of pain without mention of numbness.
      The average time from nerve injury to repair was 9.4 months (range, 3 to 50
      months). The most common intraoperative finding was a discontinuity defect (n =
      18, 33.3%), followed by partial nerve severance (n = 15, 27.8%),
      neuroma-in-continuity (n = 11, 20.3%), and compression injury (n = 10, 18.5%).
      The most frequent surgical procedure was autogenous nerve graft reconstruction of
      the IAN using the sural or great auricular nerve (n = 22, 40.7%), followed by
      excision of a neuroma with or without neurorrhaphy (n = 13, 24.1%). All the LN
      injuries (n = 14) were partial or complete severances, of which 2 were
      reconstructed with autogenous nerve grafts and the other 12 underwent
      neurorrhaphy. The long buccal nerve injury required excision of a proximal stump 
      neuroma without neurorrhaphy. After a minimum of 1-year follow-up, NST showed
      that 8 nerves (14.8%) showed no sign of recovery; 19 nerves (35.2%) had regained 
      "useful sensory function," and 27 nerves (50%) showed full recovery as described 
      by the Medical Research Council scale. CONCLUSIONS: Microsurgical repair of the
      IAN or LN injured during the SSRO can be considered in patients with persistent, 
      unacceptable sensory dysfunction in the distribution of the involved nerve.
      Modifications of surgical technique may be helpful in reducing the incidence of
      such injuries. Based on our experience, an algorithm for evaluation and treatment
      is presented.
CI  - Copyright (c) 2010 American Association of Oral and Maxillofacial Surgeons.
      Published by Elsevier Inc. All rights reserved.
FAU - Bagheri, Shahrokh C
AU  - Bagheri SC
AD  - Department Oral and Maxillofacial Surgery, Northside Hospital of Atlanta,
      Atlanta, GA, USA. sbagher@hotmail.com
FAU - Meyer, Roger A
AU  - Meyer RA
FAU - Khan, Husain Ali
AU  - Khan HA
FAU - Wallace, Jeffrey
AU  - Wallace J
FAU - Steed, Martin B
AU  - Steed MB
LA  - eng
PT  - Journal Article
DEP - 20100819
PL  - United States
TA  - J Oral Maxillofac Surg
JT  - Journal of oral and maxillofacial surgery : official journal of the American
      Association of Oral and Maxillofacial Surgeons
JID - 8206428
SB  - IM
CIN - J Oral Maxillofac Surg. 2011 Dec;69(12):2946. PMID: 22117703
MH  - Adolescent
MH  - Adult
MH  - Cranial Nerve Neoplasms/surgery
MH  - Decompression, Surgical
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hypesthesia/surgery
MH  - Lingual Nerve/surgery
MH  - *Lingual Nerve Injuries
MH  - Male
MH  - Mandible/*surgery
MH  - Mandibular Nerve/surgery
MH  - Microsurgery/*methods
MH  - Middle Aged
MH  - Nerve Compression Syndromes/surgery
MH  - Neuroma/surgery
MH  - Neurosurgical Procedures/*methods
MH  - Osteotomy/adverse effects/*methods
MH  - Pain, Postoperative/surgery
MH  - Postoperative Complications/*surgery
MH  - Reconstructive Surgical Procedures/*methods
MH  - Recovery of Function/physiology
MH  - Retrospective Studies
MH  - Sural Nerve/transplantation
MH  - Time Factors
MH  - Treatment Outcome
MH  - *Trigeminal Nerve Injuries
MH  - Young Adult
EDAT- 2010/08/24 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/24 06:00
PHST- 2010/01/28 00:00 [received]
PHST- 2010/05/12 00:00 [revised]
PHST- 2010/05/21 00:00 [accepted]
PHST- 2010/08/24 06:00 [entrez]
PHST- 2010/08/24 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S0278-2391(10)00650-6 [pii]
AID - 10.1016/j.joms.2010.05.065 [doi]
PST - ppublish
SO  - J Oral Maxillofac Surg. 2010 Nov;68(11):2770-82. doi: 10.1016/j.joms.2010.05.065.
      Epub 2010 Aug 19.


PMID- 20727487
OWN - NLM
STAT- MEDLINE
DCOM- 20110110
LR  - 20220410
IS  - 1558-0776 (Electronic)
IS  - 1071-9091 (Linking)
VI  - 17
IP  - 3
DP  - 2010 Sep
TI  - Medical management of refractory status epilepticus.
PG  - 176-81
LID - 10.1016/j.spen.2010.06.006 [doi]
AB  - This review discusses the medical management of pediatric refractory status
      epilepticus, defined here as persistent seizures of any type after the
      administration of 2 appropriate anticonvulsants. The use of both nonanesthetic
      and anesthetic anticonvulsants is discussed along with the relative strengths and
      weaknesses of each agent. Appropriate treatment goals and the use of
      electroencephalographic monitoring are described as are reasonable treatment
      algorithms. Finally, ethical considerations are briefly discussed in the context 
      of available outcome data.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Owens, James
AU  - Owens J
AD  - Department of Pediatrics and Neurology, Baylor College of Medicine, Houston, TX, 
      USA. jowens@bcm.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Semin Pediatr Neurol
JT  - Seminars in pediatric neurology
JID - 9441351
RN  - 0 (Anticonvulsants)
SB  - IM
MH  - Anticonvulsants/*administration & dosage
MH  - Child
MH  - Clinical Protocols
MH  - Drug Resistance
MH  - Humans
MH  - Infusions, Intravenous
MH  - Status Epilepticus/diagnosis/*drug therapy
EDAT- 2010/08/24 06:00
MHDA- 2011/01/11 06:00
CRDT- 2010/08/24 06:00
PHST- 2010/08/24 06:00 [entrez]
PHST- 2010/08/24 06:00 [pubmed]
PHST- 2011/01/11 06:00 [medline]
AID - S1071-9091(10)00065-3 [pii]
AID - 10.1016/j.spen.2010.06.006 [doi]
PST - ppublish
SO  - Semin Pediatr Neurol. 2010 Sep;17(3):176-81. doi: 10.1016/j.spen.2010.06.006.


PMID- 20727428
OWN - NLM
STAT- MEDLINE
DCOM- 20110310
LR  - 20141120
IS  - 1876-4347 (Electronic)
IS  - 1871-6784 (Linking)
VI  - 27
IP  - 5
DP  - 2010 Nov 30
TI  - Food insecurity, hunger and malnutrition: necessary policy and technology
      changes.
PG  - 449-52
LID - 10.1016/j.nbt.2010.08.006 [doi]
AB  - Ending food insecurity, hunger and malnutrition is a pressing global ethical
      priority. Despite differences in food production systems, cultural values and
      economic conditions, hunger is not acceptable under any ethical principles. Yet, 
      progress in combating hunger and malnutrition in developing countries has been
      discouraging, even as overall global prosperity has increased in past decades. A 
      growing number of people are deprived of the fundamental right to food, which is 
      essential for all other rights as well as for human existence itself. The food
      and nutrition crisis has deepened in recent years, as increased food price
      volatility and global recession affected the poor. In a strategic agenda, it will
      be necessary to promote pro-poor agricultural growth, reduce extreme market
      volatility and expand social protection and child nutrition action.
CI  - Copyright (c) 2010 Elsevier B.V. All rights reserved.
FAU - von Braun, Joachim
AU  - von Braun J
AD  - Center for Development Research (ZEF), University of Bonn, Germany.
      jvonbraun@uni-bonn.de
LA  - eng
PT  - Journal Article
DEP - 20100818
PL  - Netherlands
TA  - N Biotechnol
JT  - New biotechnology
JID - 101465345
SB  - IM
MH  - Agriculture/economics/*legislation & jurisprudence/*methods
MH  - Developing Countries
MH  - Food Supply/economics/*legislation & jurisprudence
MH  - Global Health
MH  - Humans
MH  - *Hunger
MH  - International Cooperation
MH  - Malnutrition/economics/*prevention & control
EDAT- 2010/08/24 06:00
MHDA- 2011/03/11 06:00
CRDT- 2010/08/24 06:00
PHST- 2010/08/10 00:00 [received]
PHST- 2010/08/11 00:00 [accepted]
PHST- 2010/08/24 06:00 [entrez]
PHST- 2010/08/24 06:00 [pubmed]
PHST- 2011/03/11 06:00 [medline]
AID - S1871-6784(10)00554-6 [pii]
AID - 10.1016/j.nbt.2010.08.006 [doi]
PST - ppublish
SO  - N Biotechnol. 2010 Nov 30;27(5):449-52. doi: 10.1016/j.nbt.2010.08.006. Epub 2010
      Aug 18.


PMID- 20727319
OWN - NLM
STAT- MEDLINE
DCOM- 20100929
LR  - 20140827
IS  - 1071-1007 (Print)
IS  - 1071-1007 (Linking)
VI  - 31
IP  - 8
DP  - 2010 Aug
TI  - The strength of achilles tendon repair: a comparison of three suture techniques
      in human cadaver tendons.
PG  - 701-5
LID - 10.3113/FAI.2010.0701 [doi]
AB  - BACKGROUND: A previous study suggests the double Krackow suture (locking-loop)
      weave technique is nearly twice as strong as the single Bunnell or single Kessler
      suture repair techniques. Our hypothesis was that the strength of different
      repair techniques would be comparable if a similar number of suture strands cross
      the repair site. MATERIALS AND METHODS: Twenty-four fresh-frozen human cadaver
      Achilles tendons were used to test maximum strength of three suture techniques
      (double Bunnell, double Kessler, and double Krackow). The simulated ruptures were
      created in the midsubstance of the Achilles tendon, five centimeters proximal to 
      its calcaneal insertion. All repairs were performed with No. 2 polyester
      (Mersilene, Ethicon, Sommerville, NJ) nonabsorbable suture in standard fashion
      for each technique, with four strands crossing the repair site. The tendons were 
      then anchored to a materials testing machine (Instron, Canton, MA) through a
      calcaneal pin distally and a modified soft tissue clamp proximally. Tendons were 
      loaded with continuous tension at a head speed of 0.85 cm/s. RESULTS: All repairs
      failed at the site of the suture knots, none pulling out through the substance of
      the tendon. A one-way analysis of variance was performed on the maximum force at 
      failure of each repair technique. No statistically significant difference was
      noted between the double Krackow weave (199.9 +/- 20 N), the double Bunnell weave
      (196.2 +/- 45 N), and the double Kessler weave (166.9 +/- 51 N). CONCLUSION: We
      found that in a laboratory model of cadaveric Achilles tendon repairs there was
      no significant difference in strength between the Krackow, Bunnell, and Kessler
      suture techniques, when each was performed with a double suture weave. CLINICAL
      RELEVANCE: This is a cadaveric study that attempts to simulate the clinical
      parameters of Achilles tendon ruptures, repairs, and repair failures to examine
      the strength of different repair techniques.
FAU - McCoy, Brett W
AU  - McCoy BW
FAU - Haddad, Steven L
AU  - Haddad SL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Foot Ankle Int
JT  - Foot & ankle international
JID - 9433869
SB  - IM
MH  - Achilles Tendon/injuries/*surgery
MH  - Cadaver
MH  - Humans
MH  - Materials Testing
MH  - Rupture/surgery
MH  - Stress, Mechanical
MH  - *Suture Techniques
EDAT- 2010/08/24 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/08/24 06:00
PHST- 2010/08/24 06:00 [entrez]
PHST- 2010/08/24 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - 50042384 [pii]
AID - 10.3113/FAI.2010.0701 [doi]
PST - ppublish
SO  - Foot Ankle Int. 2010 Aug;31(8):701-5. doi: 10.3113/FAI.2010.0701.


PMID- 20727211
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1744-8603 (Electronic)
IS  - 1744-8603 (Linking)
VI  - 6
DP  - 2010 Aug 22
TI  - Framing health and foreign policy: lessons for global health diplomacy.
PG  - 14
LID - 10.1186/1744-8603-6-14 [doi]
AB  - Global health financing has increased dramatically in recent years, indicative of
      a rise in health as a foreign policy issue. Several governments have issued
      specific foreign policy statements on global health and a new term, global health
      diplomacy, has been coined to describe the processes by which state and non-state
      actors engage to position health issues more prominently in foreign policy
      decision-making. Their ability to do so is important to advancing international
      cooperation in health. In this paper we review the arguments for health in
      foreign policy that inform global health diplomacy. These are organized into six 
      policy frames: security, development, global public goods, trade, human rights
      and ethical/moral reasoning. Each of these frames has implications for how global
      health as a foreign policy issue is conceptualized. Differing arguments within
      and between these policy frames, while overlapping, can also be contradictory.
      This raises an important question about which arguments prevail in actual state
      decision-making. This question is addressed through an analysis of policy or
      policy-related documents and academic literature pertinent to each policy framing
      with some assessment of policy practice. The reference point for this analysis is
      the explicit goal of improving global health equity. This goal has increasing
      national traction within national public health discourse and decision-making
      and, through the Millennium Development Goals and other multilateral reports and 
      declarations, is entering global health policy discussion. Initial findings
      support conventional international relations theory that most states, even when
      committed to health as a foreign policy goal, still make decisions primarily on
      the basis of the 'high politics' of national security and economic material
      interests. Development, human rights and ethical/moral arguments for global
      health assistance, the traditional 'low politics' of foreign policy, are present 
      in discourse but do not appear to dominate practice. While political momentum for
      health as a foreign policy goal persists, the framing of this goal remains a
      contested issue. The analysis offered in this article may prove helpful to those 
      engaged in global health diplomacy or in efforts to have global governance across
      a range of sectoral interests pay more attention to health equity impacts.
FAU - Labonte, Ronald
AU  - Labonte R
AD  - Department of Epidemiology and Community Medicine, Canada Research Chair,
      Globalization and Health Equity, Institute of Population Health, University of
      Ottawa, 1 Stewart Street, Ottawa, Ontario, K1N 6N5, Canada. rlabonte@uottawa.ca.
FAU - Gagnon, Michelle L
AU  - Gagnon ML
LA  - eng
PT  - Journal Article
DEP - 20100822
PL  - England
TA  - Global Health
JT  - Globalization and health
JID - 101245734
PMC - PMC2936293
EDAT- 2010/08/24 06:00
MHDA- 2010/08/24 06:01
CRDT- 2010/08/24 06:00
PHST- 2010/04/22 00:00 [received]
PHST- 2010/08/22 00:00 [accepted]
PHST- 2010/08/24 06:00 [entrez]
PHST- 2010/08/24 06:00 [pubmed]
PHST- 2010/08/24 06:01 [medline]
AID - 1744-8603-6-14 [pii]
AID - 10.1186/1744-8603-6-14 [doi]
PST - epublish
SO  - Global Health. 2010 Aug 22;6:14. doi: 10.1186/1744-8603-6-14.


PMID- 20727082
OWN - NLM
STAT- MEDLINE
DCOM- 20101223
LR  - 20151119
IS  - 1442-2018 (Electronic)
IS  - 1441-0745 (Linking)
VI  - 12
IP  - 3
DP  - 2010 Sep 1
TI  - Perceptions of Japanese patients and their family about medical treatment
      decisions.
PG  - 314-21
LID - 10.1111/j.1442-2018.2010.00532.x [doi]
AB  - Internationally, nurses and physicians are increasingly expected to undertake
      roles in communication and patient advocacy, including in Japan, where the
      reigning principle underlying medical ethics is in transition from paternalism to
      respect for patient autonomy. The study reports the results of a survey in two
      Japanese teaching hospitals that clarified the perspectives of 128 patients and
      41 family members regarding their current and desired involvement in health
      decision-making. The commonest process that was desired by patients and their
      family was for patients to make decisions after consultation with both the
      physician and their family. The decision-making preferences for competent
      patients varied among the participants, who believed that families have a crucial
      role to play in health-care decision-making, even when patients are competent to 
      make their own decisions. The findings will inform health professionals about
      contemporary Japanese health-care decision-making and the ethical issues involved
      in this process, as well as assist the future development of a culturally
      relevant model to support patients' preferences for ethical decision-making.
FAU - Ito, Misae
AU  - Ito M
AD  - Department of Nursing, Faculty of Health and Welfare, Kawasaki University of
      Medical Welfare, 288 Matsushima, Kurashiki, Okayama 701-0193, Japan.
      m-ito@mw.kawasaki-m.ac.jp
FAU - Tanida, Noritoshi
AU  - Tanida N
FAU - Turale, Sue
AU  - Turale S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Nurs Health Sci
JT  - Nursing & health sciences
JID - 100891857
SB  - IM
CIN - Nurs Health Sci. 2010 Dec;12(4):402. PMID: 21210915
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Chi-Square Distribution
MH  - Decision Making/*ethics
MH  - Developmental Disabilities/*psychology/*therapy
MH  - Family/*psychology
MH  - Female
MH  - Humans
MH  - Japan
MH  - Male
MH  - Mental Competency
MH  - Middle Aged
MH  - Patients/*psychology
MH  - Statistics, Nonparametric
MH  - Surveys and Questionnaires
EDAT- 2010/08/24 06:00
MHDA- 2010/12/25 06:00
CRDT- 2010/08/24 06:00
PHST- 2010/08/24 06:00 [entrez]
PHST- 2010/08/24 06:00 [pubmed]
PHST- 2010/12/25 06:00 [medline]
AID - NHS532 [pii]
AID - 10.1111/j.1442-2018.2010.00532.x [doi]
PST - ppublish
SO  - Nurs Health Sci. 2010 Sep 1;12(3):314-21. doi: 10.1111/j.1442-2018.2010.00532.x.


PMID- 20726929
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20181201
IS  - 1365-2702 (Electronic)
IS  - 0962-1067 (Linking)
VI  - 19
IP  - 21-22
DP  - 2010 Nov
TI  - Nursing staff perceptions of the use of physical restraint in institutional care 
      of older people in Finland.
PG  - 3197-207
LID - 10.1111/j.1365-2702.2010.03232.x [doi]
AB  - AIMS AND OBJECTIVES: To describe the perceptions of nursing staff on the use of
      physical restraints in institutional care of older people. BACKGROUND: Physical
      restraint of older people is a common practice in institutional care in many
      countries, including Finland. As the nursing staff plays a major role in deciding
      on physically restraining older patient and in the care the patient receives, new
      research information is needed on the nursing staff's attitudes towards the use
      of physical restraints. DESIGN: A qualitative study. METHOD: The data consisted
      of focus group interviews with staff and supervisors. There were four focus
      groups: nurses, practical nurses, institutional assistants and care supervisors. 
      RESULTS: In addition to traditional methods of restraint, such as belts and
      locked doors, the nursing staff also used indirect restraint by removing the
      patient's mobility aid. Factors contributing to the use of restraints included
      requests by the patient's family members to use restraint to ensure the patient's
      safety and social reasons, in the form of lack of legislation on the use of
      restraint. The use of restraints caused feelings of guilt among the nursing
      staff, but on the other hand, it was seen as a way of making older patient feel
      more secure. CONCLUSIONS: There is a need for official guidelines on the use of
      physical restraints in care of older people. This would require the entire
      nursing team to make a joint decision on the use of restraints and constant
      reassessment of the need of using restraints. RELEVANCE TO CLINICAL PRACTICE: The
      results of the study provide nursing staff and supervisors a chance to ethically 
      deliberate and evaluate their own work. Alternative practices for physical
      restraint can also be directly applied to practical care of older people.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Saarnio, Reetta
AU  - Saarnio R
AD  - Faculty of Medicine, Institute of Health Sciences, University of Oulu, Oulu,
      Finland. reetta.saarnio@oulu.fi
FAU - Isola, Arja
AU  - Isola A
LA  - eng
PT  - Journal Article
DEP - 20100818
PL  - England
TA  - J Clin Nurs
JT  - Journal of clinical nursing
JID - 9207302
MH  - Aged
MH  - Aged, 80 and over
MH  - Attitude of Health Personnel
MH  - Female
MH  - Finland
MH  - Geriatric Nursing/methods
MH  - *Homes for the Aged
MH  - Humans
MH  - Male
MH  - *Nursing Homes
MH  - Nursing Staff
MH  - Qualitative Research
MH  - Restraint, Physical/*statistics & numerical data
EDAT- 2010/08/24 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/08/24 06:00
PHST- 2010/08/24 06:00 [entrez]
PHST- 2010/08/24 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - JCN3232 [pii]
AID - 10.1111/j.1365-2702.2010.03232.x [doi]
PST - ppublish
SO  - J Clin Nurs. 2010 Nov;19(21-22):3197-207. doi: 10.1111/j.1365-2702.2010.03232.x. 
      Epub 2010 Aug 18.


PMID- 20726870
OWN - NLM
STAT- MEDLINE
DCOM- 20110622
LR  - 20101102
IS  - 1742-6723 (Electronic)
IS  - 1742-6723 (Linking)
VI  - 22
IP  - 5
DP  - 2010 Oct
TI  - A primer for clinical researchers in the emergency department: part I: ethical
      and regulatory background.
PG  - 399-406
LID - 10.1111/j.1742-6723.2010.01320.x [doi]
AB  - Research is an important part of emergency medicine and provides the scientific
      underpinning for optimal patient care. Although increasing numbers of emergency
      physicians participate in research activities, formal research training is
      currently neither part of emergency physician training in Australia nor easily
      available for clinicians interested in clinical research. In a two-part series,
      which is targeted at part-time clinical researchers in the ED, we set out and
      explain the key elements for conducting high-quality and ethical research. In
      Part I, we describe important underlying ethical principles for research in
      humans and explain key regulatory processes and documents pertaining to good
      clinical research practice in Australia. The ethics of research in children as a 
      particularly vulnerable group will also be addressed. Part II will address
      important elements of research science and conduct.
CI  - (c) 2010 The Authors. Emergency Medicine Australasia (c) 2010 Australasian
      College for Emergency Medicine and Australasian Society for Emergency Medicine.
FAU - Davidson, Andrew
AU  - Davidson A
AD  - Department of Anesthesia and Pain Mangement, Royal Children's Hospital, Murdoch
      Children's Research Institute, Melbourne, Victoria, Australia.
FAU - Babl, Franz E
AU  - Babl FE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100818
PL  - Australia
TA  - Emerg Med Australas
JT  - Emergency medicine Australasia : EMA
JID - 101199824
SB  - IM
MH  - Australia
MH  - Child
MH  - Child Welfare/ethics/legislation & jurisprudence
MH  - Confidentiality/ethics
MH  - Emergency Service, Hospital/ethics/*legislation & jurisprudence
MH  - *Ethics, Research
MH  - Government Regulation
MH  - Health Services Research/ethics/*legislation & jurisprudence
MH  - Humans
MH  - Privacy
MH  - Scientific Misconduct/ethics
EDAT- 2010/08/24 06:00
MHDA- 2011/06/23 06:00
CRDT- 2010/08/24 06:00
PHST- 2010/08/24 06:00 [entrez]
PHST- 2010/08/24 06:00 [pubmed]
PHST- 2011/06/23 06:00 [medline]
AID - EMM1320 [pii]
AID - 10.1111/j.1742-6723.2010.01320.x [doi]
PST - ppublish
SO  - Emerg Med Australas. 2010 Oct;22(5):399-406. doi:
      10.1111/j.1742-6723.2010.01320.x. Epub 2010 Aug 18.


PMID- 20726869
OWN - NLM
STAT- MEDLINE
DCOM- 20110622
LR  - 20101102
IS  - 1742-6723 (Electronic)
IS  - 1742-6723 (Linking)
VI  - 22
IP  - 5
DP  - 2010 Oct
TI  - A primer for clinical researchers in the emergency department: Part II: research 
      science and conduct.
PG  - 407-17
LID - 10.1111/j.1742-6723.2010.01321.x [doi]
AB  - Research is an important part of emergency medicine and provides the scientific
      underpinning for optimal patient care. Although increasing numbers of emergency
      physicians participate in research activities, formal research training is
      currently neither part of emergency physician training in Australia nor easily
      available for clinicians interested in clinical research. In a two-part series,
      which is targeted at part-time clinical researchers in the ED, we set out and
      explain the key elements for conducting high-quality and ethical research. Part I
      addressed ethical and regulatory aspects. In Part II, we describe important
      elements of research science, and practical elements of research conduct and
      administration, which form the basis for high-quality research.
CI  - (c) 2010 The Authors. Emergency Medicine Australasia (c) 2010 Australasian
      College for Emergency Medicine and Australasian Society for Emergency Medicine.
FAU - Babl, Franz E
AU  - Babl FE
AD  - Emergency Department, Royal Children's Hospital, Murdoch Children's Research
      Institute, Victoria, Australia. franz.babl@rch.org.au
FAU - Davidson, Andrew
AU  - Davidson A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100818
PL  - Australia
TA  - Emerg Med Australas
JT  - Emergency medicine Australasia : EMA
JID - 101199824
SB  - IM
CIN - Emerg Med Australas. 2011 Feb;23(1):108. PMID: 21284823
MH  - Australia
MH  - Databases, Factual
MH  - Documentation
MH  - Emergency Service, Hospital/*organization & administration
MH  - *Ethics, Research
MH  - Health Services Research/ethics/*methods
MH  - Humans
MH  - Risk Management
EDAT- 2010/08/24 06:00
MHDA- 2011/06/23 06:00
CRDT- 2010/08/24 06:00
PHST- 2010/08/24 06:00 [entrez]
PHST- 2010/08/24 06:00 [pubmed]
PHST- 2011/06/23 06:00 [medline]
AID - EMM1321 [pii]
AID - 10.1111/j.1742-6723.2010.01321.x [doi]
PST - ppublish
SO  - Emerg Med Australas. 2010 Oct;22(5):407-17. doi:
      10.1111/j.1742-6723.2010.01321.x. Epub 2010 Aug 18.


PMID- 20726464
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20211020
IS  - 1470-2118 (Print)
IS  - 1470-2118 (Linking)
VI  - 10
IP  - 3
DP  - 2010 Jun
TI  - Ethical and legal issues in end-of-life care.
PG  - 282-5
AB  - The doctor has a responsibility to develop and maintain an effective approach to 
      ethical decision making and the skills to implement the correct moral action. At 
      the heart of this process is the experience and knowledge of particular
      conditions and their outcomes, alongside excellence in communication skills and
      working with colleagues.
FAU - Thorns, Andrew
AU  - Thorns A
AD  - Pilgrims Hospices, East Kent NHS Foundation University Trust, University of Kent,
      Margate. andrew_thorns@pilgrimshospice.org
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Med (Lond)
JT  - Clinical medicine (London, England)
JID - 101092853
RN  - 0 (Hypnotics and Sedatives)
SB  - IM
MH  - Decision Making
MH  - Dehydration/prevention & control
MH  - Ethics, Medical
MH  - Humans
MH  - Hypnotics and Sedatives/administration & dosage
MH  - Nutritional Support
MH  - Palliative Care
MH  - *Personal Autonomy
MH  - Terminal Care/*ethics/*legislation & jurisprudence/psychology
PMC - PMC5873559
EDAT- 2010/08/24 06:00
MHDA- 2010/09/16 06:00
CRDT- 2010/08/24 06:00
PHST- 2010/08/24 06:00 [entrez]
PHST- 2010/08/24 06:00 [pubmed]
PHST- 2010/09/16 06:00 [medline]
AID - 10.7861/clinmedicine.10-3-282 [doi]
PST - ppublish
SO  - Clin Med (Lond). 2010 Jun;10(3):282-5. doi: 10.7861/clinmedicine.10-3-282.


PMID- 20726455
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20190608
IS  - 1470-2118 (Print)
IS  - 1470-2118 (Linking)
VI  - 10
IP  - 3
DP  - 2010 Jun
TI  - Medicine as a profession.
PG  - 246-7
AB  - Over half a century ago, a Canadian judge defined a profession in a way that
      resonates still today, not only for lawyers and doctors, but for the current wide
      variety of professions and professionals. This article is a reflection on this
      definition. It briefly considers the historical context within which the
      knowledge base that characterises a profession evolved and what the various
      component parts of the judge's definition entail. A final consideration goes
      beyond the terms of the definition proposed--that of our ethical responsibility
      as professionals to stand up and be counted and, in the context of the disorder
      around us, to speak out.
FAU - Funder, John W
AU  - Funder JW
AD  - Prince Henry's Institute of Medical Research, Monash Medical Centre, Clayton,
      Victoria, Australia. John.Funder@princehenrys.org
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Med (Lond)
JT  - Clinical medicine (London, England)
JID - 101092853
SB  - IM
MH  - *Ethics, Medical
MH  - Humans
MH  - Physicians/*ethics
EDAT- 2010/08/24 06:00
MHDA- 2010/09/16 06:00
CRDT- 2010/08/24 06:00
PHST- 2010/08/24 06:00 [entrez]
PHST- 2010/08/24 06:00 [pubmed]
PHST- 2010/09/16 06:00 [medline]
AID - 10.7861/clinmedicine.10-3-246 [doi]
PST - ppublish
SO  - Clin Med (Lond). 2010 Jun;10(3):246-7. doi: 10.7861/clinmedicine.10-3-246.


PMID- 20726137
OWN - HSR
STAT- MEDLINE
DCOM- 20100827
LR  - 20100820
IS  - 1558-6847 (Electronic)
IS  - 1558-6847 (Linking)
VI  - 95
DP  - 2010 Aug
TI  - The ethical review of health care quality improvement initiatives: findings from 
      the field.
PG  - 1-12
AB  - Questions have been raised about whether and how health care quality improvement 
      (QI) initiatives ought to be reviewed to address possible ethical issues
      associated with them. These questions have focused primarily on whether some QI
      initiatives meet the regulatory criteria for human subject research and should
      therefore be regulated and reviewed as such. Based on surveys of health care
      system professionals conducting QI initiatives and hospital CEOs, this issue
      brief finds that QI initiatives are routinely reviewed by a variety of internal
      mechanisms prior to implementation, although rarely through an institutional
      review board or another independent body charged specifically with ethical
      oversight of QI initiatives. Further research, the authors say, is needed to
      achieve a better understanding of how review mechanisms for QI initiatives are
      structured, including information on who reviews these activities, how they are
      reviewed, and whether such processes include an ethical assessment of the
      proposed QI initiative.
FAU - Taylor, Holly A
AU  - Taylor HA
AD  - Department of Health Policy and Management, Johns Hopkins Bloomberg School of
      Public Health, and Berman Institute of Bioethics at the Johns Hopkins University,
      USA. htaylor@jhsph.edu
FAU - Pronovost, Peter J
AU  - Pronovost PJ
FAU - Faden, Ruth R
AU  - Faden RR
FAU - Kass, Nancy E
AU  - Kass NE
FAU - Sugarman, Jeremy
AU  - Sugarman J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Issue Brief (Commonw Fund)
JT  - Issue brief (Commonwealth Fund)
JID - 101087100
MH  - Confidentiality/ethics
MH  - Data Collection/ethics
MH  - Ethics Committees, Research/*ethics
MH  - *Ethics, Institutional
MH  - *Ethics, Research
MH  - Hospitals/*ethics
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Privacy
MH  - Quality Assurance, Health Care/*ethics
MH  - United States
EDAT- 2010/08/24 06:00
MHDA- 2010/08/28 06:00
CRDT- 2010/08/24 06:00
PHST- 2010/08/24 06:00 [entrez]
PHST- 2010/08/24 06:00 [pubmed]
PHST- 2010/08/28 06:00 [medline]
PST - ppublish
SO  - Issue Brief (Commonw Fund). 2010 Aug;95:1-12.


PMID- 20725876
OWN - NLM
STAT- MEDLINE
DCOM- 20110315
LR  - 20131121
IS  - 1438-9010 (Electronic)
IS  - 1438-9010 (Linking)
VI  - 183
IP  - 2
DP  - 2011 Feb
TI  - T2' Imaging of Native Kidneys and Renal Allografts - a Feasibility Study.
PG  - 112-9
LID - 10.1055/s-0029-1245597 [doi]
AB  - PURPOSE: To evaluate the feasibility of T2' mapping in native kidneys and renal
      allografts. MATERIALS AND METHODS: Following approval of the local ethics
      committee, 24 renal allograft recipients and 10 control subjects (healthy
      volunteers) were included in this study. Multi-echo T2 and T2* imaging was
      performed on a 1.5 Tesla scanner. Allograft recipients were assigned to two
      groups: group a), 8 patients with good (glomerular filtration rate of more than
      40 ml/min) allograft function and no evidence of transplant rejection, transplant
      renal artery stenosis or ureteral obstruction; group b), 16 patients with
      deterioration of renal graft function (glomerular filtration rate (GFR) of 40
      ml/min or less). Two different imaging protocols were tested. RESULTS: The mean
      T2' relaxation parameters were 108.33 msec +/- 13.34, 100.00 msec +/- 18.89 and
      124.57 msec +/- 6.51 for groups a), b) and for control subjects, respectively.
      The reduction of T2' values in patient group b) was not statistically
      significant. However, significant correlations could be demonstrated between T2' 
      values and the glomerular filtration rate (GFR) of renal allograft function. The 
      reproducibility was tested and the coefficients of variation of T2' values in the
      cortex of transplanted kidneys were 11.1% within subjects and 11.3% between
      subjects. CONCLUSION: Our results indicate that T2' imaging is a promising
      non-enhanced technique, which seems to reveal information on transplant function.
      Further studies are required to determine the clinical value of T2' mapping for
      monitoring renal allograft recipients.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Mathys, C
AU  - Mathys C
AD  - Institute of Radiology, University Clinic Dusseldorf, Germany.
      mathys@uni-duesseldorf.de
FAU - Blondin, D
AU  - Blondin D
FAU - Wittsack, H-J
AU  - Wittsack HJ
FAU - Miese, F R
AU  - Miese FR
FAU - Rybacki, K
AU  - Rybacki K
FAU - Walther, C
AU  - Walther C
FAU - Holstein, A
AU  - Holstein A
FAU - Lanzman, R S
AU  - Lanzman RS
LA  - eng
PT  - Journal Article
DEP - 20100819
PL  - Germany
TA  - Rofo
JT  - RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin
JID - 7507497
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Feasibility Studies
MH  - Female
MH  - Glomerular Filtration Rate/physiology
MH  - Graft Rejection/*diagnosis/physiopathology
MH  - Humans
MH  - Image Enhancement/*methods
MH  - Image Processing, Computer-Assisted/*methods
MH  - Kidney/*pathology/physiopathology
MH  - Kidney Transplantation/*pathology/physiology
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Oxygen/*blood
MH  - Postoperative Complications/*diagnosis/physiopathology
MH  - Reference Values
MH  - Renal Artery Obstruction/*diagnosis/physiopathology
MH  - Reproducibility of Results
MH  - Software
MH  - Ureteral Obstruction/*diagnosis/physiopathology
MH  - Young Adult
EDAT- 2010/08/21 06:00
MHDA- 2011/03/16 06:00
CRDT- 2010/08/21 06:00
PHST- 2010/08/21 06:00 [entrez]
PHST- 2010/08/21 06:00 [pubmed]
PHST- 2011/03/16 06:00 [medline]
AID - 10.1055/s-0029-1245597 [doi]
PST - ppublish
SO  - Rofo. 2011 Feb;183(2):112-9. doi: 10.1055/s-0029-1245597. Epub 2010 Aug 19.


PMID- 20725013
OWN - NLM
STAT- MEDLINE
DCOM- 20101008
LR  - 20211020
IS  - 1476-4687 (Electronic)
IS  - 0028-0836 (Linking)
VI  - 466
IP  - 7309
DP  - 2010 Aug 19
TI  - E-mails spark ethics row.
PG  - 913
LID - 10.1038/466913a [doi]
FAU - Dalton, Rex
AU  - Dalton R
LA  - eng
PT  - News
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (Herbicides)
RN  - QJA9M5H4IM (Atrazine)
SB  - IM
MH  - Animals
MH  - Anura/physiology
MH  - Atrazine/*adverse effects
MH  - *Chemical Industry
MH  - Electronic Mail/*ethics
MH  - Female
MH  - Herbicides/*adverse effects
MH  - Humans
MH  - Male
MH  - *Research Personnel
MH  - Sex Characteristics
MH  - United States
EDAT- 2010/08/21 06:00
MHDA- 2010/10/12 06:00
CRDT- 2010/08/21 06:00
PHST- 2010/08/21 06:00 [entrez]
PHST- 2010/08/21 06:00 [pubmed]
PHST- 2010/10/12 06:00 [medline]
AID - 466913a [pii]
AID - 10.1038/466913a [doi]
PST - ppublish
SO  - Nature. 2010 Aug 19;466(7309):913. doi: 10.1038/466913a.


PMID- 20724671
OWN - NLM
STAT- MEDLINE
DCOM- 20101005
LR  - 20211020
IS  - 1541-0048 (Electronic)
IS  - 0090-0036 (Linking)
VI  - 100
IP  - 10
DP  - 2010 Oct
TI  - HPV vaccination's second act: promotion, competition, and compulsion.
PG  - 1841-4
LID - 10.2105/AJPH.2010.193060 [doi]
AB  - Developments regarding human papillomavirus (HPV) vaccines will transform HPV
      vaccination in the United States while simultaneously raising several new policy 
      and ethical concerns. Policymakers, vaccine manufacturers, and the public health 
      community must now respond to the presence of competing vaccines that are similar
      but distinct, particularly with respect to genital wart prevention and the
      benefits of vaccinating males. This work arises in the shadow of the contentious 
      introduction of the HPV vaccine Gardasil (Merck & Co, Inc, Whitehouse Station,
      NJ) in 2006, particularly the opposition to efforts in many states to require the
      vaccine for school attendance. I review the current status of HPV vaccine policy 
      in the United States and examine issues of public health ethics and policy
      central to ongoing and future HPV vaccination programs.
FAU - Schwartz, Jason L
AU  - Schwartz JL
AD  - Center forBioethics and Department of History andSociology of Science, University
      ofPennsylvania, Philadelphia, PA 19104, USA. jlschwa2@mail.med.upenn.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100819
PL  - United States
TA  - Am J Public Health
JT  - American journal of public health
JID - 1254074
RN  - 0 (Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18)
RN  - 0 (Papillomavirus Vaccines)
RN  - 0 (human papillomavirus vaccine, L1 type 16, 18)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Centers for Disease Control and Prevention, U.S.
MH  - Child
MH  - Condylomata Acuminata/*prevention & control
MH  - Drug Approval
MH  - Female
MH  - Health Policy/*legislation & jurisprudence
MH  - Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18
MH  - Humans
MH  - Immunization Schedule
MH  - Male
MH  - Mass Vaccination/*legislation & jurisprudence
MH  - Papillomavirus Vaccines/*administration & dosage/standards
MH  - United States
MH  - Uterine Cervical Neoplasms/*prevention & control
MH  - Young Adult
PMC - PMC2936995
EDAT- 2010/08/21 06:00
MHDA- 2010/10/06 06:00
CRDT- 2010/08/21 06:00
PHST- 2010/08/21 06:00 [entrez]
PHST- 2010/08/21 06:00 [pubmed]
PHST- 2010/10/06 06:00 [medline]
AID - AJPH.2010.193060 [pii]
AID - 10.2105/AJPH.2010.193060 [doi]
PST - ppublish
SO  - Am J Public Health. 2010 Oct;100(10):1841-4. doi: 10.2105/AJPH.2010.193060. Epub 
      2010 Aug 19.


PMID- 20724418
OWN - NLM
STAT- MEDLINE
DCOM- 20101208
LR  - 20191210
IS  - 1538-6724 (Electronic)
IS  - 0031-9023 (Linking)
VI  - 90
IP  - 11
DP  - 2010 Nov
TI  - The Move & PLAY study: an example of comprehensive rehabilitation outcomes
      research.
PG  - 1660-72
LID - 10.2522/ptj.20090424 [doi]
AB  - This perspective article provides an example of a study planned using guidelines 
      for comprehensive rehabilitation outcomes research, an approach that is believed 
      to give service providers meaningful evidence to support practice. This line of
      investigation has been guided by the World Health Organization's International
      Classification of Functioning, Disability and Health. The short title of a study 
      under way is Move & PLAY (Movement and Participation in Life Activities of Young 
      Children). The article briefly describes the conceptual model, provides
      guidelines on how indicators and measures are selected, alludes to the details of
      selected measures, and describes processes of preparing for data collection,
      including obtaining ethics approval, preparing data collection booklets, training
      assessors and interviewers, and sampling. The aim of this investigation is to
      gain a better understanding of the multiple child, family, and service factors
      associated with changes in mobility, self-care, and play of preschool children
      with cerebral palsy as a result of using this research method. Comprehensive
      rehabilitation outcomes research holds promise in providing evidence that
      supports the complexities of planning rehabilitation services with clients with
      chronic conditions, such as children with cerebral palsy.
FAU - Bartlett, Doreen J
AU  - Bartlett DJ
AD  - School of Physical Therapy, Faculty of Health Sciences, 1588 Elborn College, The 
      University of Western Ontario, London, Ontario, Canada N6G 1H1. djbartle@uwo.ca
FAU - Chiarello, Lisa A
AU  - Chiarello LA
FAU - McCoy, Sarah Westcott
AU  - McCoy SW
FAU - Palisano, Robert J
AU  - Palisano RJ
FAU - Rosenbaum, Peter L
AU  - Rosenbaum PL
FAU - Jeffries, Lynn
AU  - Jeffries L
FAU - Fiss, Alyssa Laforme
AU  - Fiss AL
FAU - Stoskopf, Barbara
AU  - Stoskopf B
LA  - eng
GR  - MOP 81107/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20100819
PL  - United States
TA  - Phys Ther
JT  - Physical therapy
JID - 0022623
SB  - IM
CIN - Phys Ther. 2010 Nov;90(11):1673-5; author reply 1675-6. PMID: 21041185
MH  - Activities of Daily Living
MH  - Cerebral Palsy/physiopathology/*rehabilitation
MH  - Child
MH  - Disability Evaluation
MH  - Evidence-Based Practice
MH  - Humans
MH  - Longitudinal Studies
MH  - Movement/physiology
MH  - Outcome Assessment, Health Care/*methods
MH  - Play and Playthings
MH  - Self Care
EDAT- 2010/08/21 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/21 06:00
PHST- 2010/08/21 06:00 [entrez]
PHST- 2010/08/21 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - ptj.20090424 [pii]
AID - 10.2522/ptj.20090424 [doi]
PST - ppublish
SO  - Phys Ther. 2010 Nov;90(11):1660-72. doi: 10.2522/ptj.20090424. Epub 2010 Aug 19.


PMID- 20724011
OWN - NLM
STAT- MEDLINE
DCOM- 20110318
LR  - 20220310
IS  - 1879-0887 (Electronic)
IS  - 0167-8140 (Linking)
VI  - 97
IP  - 2
DP  - 2010 Nov
TI  - Detection of radiation-induced lung injury in non-small cell lung cancer patients
      using hyperpolarized helium-3 magnetic resonance imaging.
PG  - 244-8
LID - 10.1016/j.radonc.2010.07.013 [doi]
AB  - PURPOSE: To compare hyperpolarized helium-3 magnetic resonance imaging
      ((3)He-MRI) acquired from non-small cell lung cancer (NSCLC) patients before and 
      after external beam radiotherapy (EBRT). METHODS AND MATERIALS: In an Ethics
      Committee-approved prospective study, five patients with histologically confirmed
      NSCLC gave written informed consent to undergo computed tomography (CT) and
      (3)He-MR ventilation imaging 1 week prior to and 3 months after radiotherapy.
      Images were registered to pre-treatment CT using anatomical landmark-based rigid 
      registration to enable comparison. Emphysema was graded from examination of the
      CT. MRI-defined ventilation was calculated as the intersection of (3)He-MRI and
      CT lung volume as a percentage of the CT lung volume for the whole lung and
      regions of CT-defined pneumonitis. RESULTS: On pre-treatment images, there was a 
      significant correlation between the degree of CT-defined emphysema and (3)He-MRI 
      whole lung ventilation (Spearman's rho=0.90, p=0.04). After radiation therapy,
      pneumonitis was evident on CT for 3/5 patients. For these cases, (3)He-MRI
      ventilation was significantly reduced within the regions of pneumonitis (pre:
      94.1+/-2.2%, post: 73.7+/-4.7%; matched pairs Student's t-test, p=0.02, mean
      difference=20.4%, 95% confidence interval 6.3-34.6%). CONCLUSIONS: This work
      demonstrates the feasibility of detecting ventilation changes between pre- and
      post-treatment using hyperpolarized helium-3 MRI for patients with NSCLC.
      Pre-treatment, the degree of emphysema and (3)He-MRI ventilation were correlated.
      For three cases of radiation pneumonitis, (3)He-MRI ventilation changes between
      pre- and post-treatment imaging were consistent with CT evidence of
      radiation-induced lung injury.
CI  - Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Ireland, Rob H
AU  - Ireland RH
AD  - Academic Unit of Clinical Oncology, University of Sheffield, UK.
      r.ireland@sheffield.ac.uk
FAU - Din, Omar S
AU  - Din OS
FAU - Swinscoe, James A
AU  - Swinscoe JA
FAU - Woodhouse, Neil
AU  - Woodhouse N
FAU - van Beek, Edwin J R
AU  - van Beek EJ
FAU - Wild, Jim M
AU  - Wild JM
FAU - Hatton, Matthew Q
AU  - Hatton MQ
LA  - eng
GR  - G0701127/MRC_/Medical Research Council/United Kingdom
GR  - N&AHP/PDA/04/012/DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100817
PL  - Ireland
TA  - Radiother Oncol
JT  - Radiotherapy and oncology : journal of the European Society for Therapeutic
      Radiology and Oncology
JID - 8407192
RN  - 0 (Isotopes)
RN  - 206GF3GB41 (Helium)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Carcinoma, Non-Small-Cell Lung/diagnostic imaging/pathology/radiotherapy
MH  - *Helium
MH  - Humans
MH  - Isotopes
MH  - *Lung Injury/diagnostic imaging/pathology
MH  - *Magnetic Resonance Imaging
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - *Radiation Injuries
MH  - Radiotherapy Dosage
MH  - Tomography, X-Ray Computed
EDAT- 2010/08/21 06:00
MHDA- 2011/03/19 06:00
CRDT- 2010/08/21 06:00
PHST- 2009/10/07 00:00 [received]
PHST- 2010/07/01 00:00 [revised]
PHST- 2010/07/13 00:00 [accepted]
PHST- 2010/08/21 06:00 [entrez]
PHST- 2010/08/21 06:00 [pubmed]
PHST- 2011/03/19 06:00 [medline]
AID - S0167-8140(10)00404-4 [pii]
AID - 10.1016/j.radonc.2010.07.013 [doi]
PST - ppublish
SO  - Radiother Oncol. 2010 Nov;97(2):244-8. doi: 10.1016/j.radonc.2010.07.013. Epub
      2010 Aug 17.


PMID- 20723873
OWN - NLM
STAT- MEDLINE
DCOM- 20101206
LR  - 20101108
IS  - 1097-6868 (Electronic)
IS  - 0002-9378 (Linking)
VI  - 203
IP  - 5
DP  - 2010 Nov
TI  - A randomized study comparing the use of the Ligaclip with bipolar energy to
      prevent lymphocele during laparoscopic pelvic lymphadenectomy for gynecologic
      cancer.
PG  - 483.e1-6
LID - 10.1016/j.ajog.2010.06.053 [doi]
AB  - OBJECTIVE: This prospective randomized pilot study compared the use of the
      Ligaclip (Ethicon Endo-Surgery, Cincinnati, OH) with bipolar coagulation in
      preventing lymphoceles after laparoscopic pelvic lymphadenectomy for gynecologic 
      cancer. STUDY DESIGN: Thirty patients with gynecologic malignancy, who had
      laparoscopic pelvic lymphadenectomy were randomly assigned for lymphadenectomy in
      1 side of the pelvis using the Ligaclip, whereas, in the other side, the bipolar 
      coagulation to seal lymphatic vessels was used. RESULTS: At ultrasound
      examination, we detected lymphocele in 10 patients (33%). Lymphocele developed in
      9 (30%) patients on the side where laparoscopic pelvic lymphadenectomy was
      perfomed using bipolar coagulation, and in 1 (3.3%) patient on the side where
      laparoscopic pelvic lymphadenectomy was performed using the Ligaclip. Univariate 
      analysis revealed that the Ligaclip's use compared with electrocoagulation in the
      laparoscopic pelvic lymphadenectomy is an independent predictive factor for
      development of lymphocele (P = .006). CONCLUSION: This study demonstrates that
      the use of the Ligaclip to close lymphatic vessels may reduce the incidence of
      lymphoceles in patients undergoing laparoscopic pelvic lymphadenectomy.
CI  - Copyright (c) 2010 Mosby, Inc. All rights reserved.
FAU - Gallotta, Valerio
AU  - Gallotta V
AD  - Division of Gynecologic Oncology, Catholic University of the Sacred Heart, Rome, 
      Italy.
FAU - Fanfani, Francesco
AU  - Fanfani F
FAU - Rossitto, Cristiano
AU  - Rossitto C
FAU - Vizzielli, Giuseppe
AU  - Vizzielli G
FAU - Testa, Antonia
AU  - Testa A
FAU - Scambia, Giovanni
AU  - Scambia G
FAU - Fagotti, Anna
AU  - Fagotti A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20100817
PL  - United States
TA  - Am J Obstet Gynecol
JT  - American journal of obstetrics and gynecology
JID - 0370476
SB  - IM
MH  - Adult
MH  - Aged
MH  - Electrocoagulation/adverse effects/*methods
MH  - Endometrial Neoplasms/*surgery
MH  - Female
MH  - Humans
MH  - Laparoscopy/adverse effects/*methods
MH  - Lymph Node Excision/adverse effects/*methods
MH  - Lymphocele/etiology/*prevention & control/surgery
MH  - Middle Aged
MH  - Pilot Projects
MH  - Prospective Studies
MH  - Treatment Outcome
MH  - Uterine Cervical Neoplasms/*surgery
EDAT- 2010/08/21 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/21 06:00
PHST- 2010/01/27 00:00 [received]
PHST- 2010/05/08 00:00 [revised]
PHST- 2010/06/22 00:00 [accepted]
PHST- 2010/08/21 06:00 [entrez]
PHST- 2010/08/21 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S0002-9378(10)00833-1 [pii]
AID - 10.1016/j.ajog.2010.06.053 [doi]
PST - ppublish
SO  - Am J Obstet Gynecol. 2010 Nov;203(5):483.e1-6. doi: 10.1016/j.ajog.2010.06.053.
      Epub 2010 Aug 17.


PMID- 20723794
OWN - NLM
STAT- MEDLINE
DCOM- 20100928
LR  - 20100820
IS  - 1097-6817 (Electronic)
IS  - 0194-5998 (Linking)
VI  - 143
IP  - 3
DP  - 2010 Sep
TI  - Ethical conduct of human research: some controversies.
PG  - 469-70
LID - 10.1016/j.otohns.2010.06.815 [doi]
FAU - Pitak-Arnnop, Poramate
AU  - Pitak-Arnnop P
FAU - Hemprich, Alexander
AU  - Hemprich A
FAU - Dhanuthai, Kittipong
AU  - Dhanuthai K
FAU - Pausch, Niels Christian
AU  - Pausch NC
LA  - eng
PT  - Comment
PT  - Letter
PL  - England
TA  - Otolaryngol Head Neck Surg
JT  - Otolaryngology--head and neck surgery : official journal of American Academy of
      Otolaryngology-Head and Neck Surgery
JID - 8508176
SB  - IM
CON - Otolaryngol Head Neck Surg. 2010 Apr;142(4):472-86. PMID: 20304264
MH  - Human Experimentation/ethics
MH  - Humans
MH  - Peer Review, Research/ethics
MH  - *Scientific Misconduct
MH  - Truth Disclosure/ethics
EDAT- 2010/08/21 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/08/21 06:00
PHST- 2010/06/03 00:00 [received]
PHST- 2010/06/07 00:00 [accepted]
PHST- 2010/08/21 06:00 [entrez]
PHST- 2010/08/21 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - S0194-5998(10)01630-X [pii]
AID - 10.1016/j.otohns.2010.06.815 [doi]
PST - ppublish
SO  - Otolaryngol Head Neck Surg. 2010 Sep;143(3):469-70. doi:
      10.1016/j.otohns.2010.06.815.


PMID- 20723154
OWN - NLM
STAT- MEDLINE
DCOM- 20110901
LR  - 20131106
IS  - 1471-6712 (Electronic)
IS  - 0283-9318 (Linking)
VI  - 25
IP  - 2
DP  - 2011 Jun
TI  - Seeking a balance between employment and the care of an ageing parent.
PG  - 285-93
LID - 10.1111/j.1471-6712.2010.00824.x [doi]
AB  - RATIONALE: A growing number of middle-aged people are engaged in informal care of
      their parents while employed. To provide support as employers, co-workers or
      staff, health care professionals need insight into the experiences of people
      managing these responsibilities. AIM: To elucidate the experience of providing
      informal care to an ageing parent while managing the responsibilities of a
      working life. METHODS: Narrative interviews were performed with 11 persons with
      experience of the phenomenon. Transcribed interviews were analysed with
      phenomenological hermeneutics. ETHICS: Informed consent was given prior to the
      interviews. The study was approved by a research ethics committee. FINDINGS:
      Providing informal care to an ageing parent while also pursuing a working life
      implies seeking balance: a balance between providing support to the parent's
      needs and one's responsibilities at work. Being employed supports this balance as
      it provides both fulfilment and refuge. Being capable of managing both roles
      grants a sense of satisfaction, supporting one's sense of balance in life. The
      balance can be supported by sharing the responsibility of caring for the ageing
      parent with others. STUDY LIMITATIONS: Despite perceived saturation and an effort
      to provide for the possibility to consider internal consistency, the findings
      should be considered as a contribution to the understanding of the phenomenon, as
      experienced by individuals in their life world. CONCLUSIONS: It is essential to
      recognise the impact that providing care for an ageing parent may have on the
      lives of a growing number of people, particularly if they have employment
      responsibilities. Acknowledgement by others supports one's ability to attain
      balance; as co-workers and managers, we can acknowledge the efforts of an
      informal caregiver and as health care staff recognise the valuable contribution
      made by people in mid-life who provide informal care for their ageing parents.
CI  - (c) 2010 The Authors. Scandinavian Journal of Caring Sciences (c) 2010 Nordic
      College of Caring Science.
FAU - Eldh, Ann Catrine
AU  - Eldh AC
AD  - Department of Neurobiology, Care Sciences and Society, Karolinska Institutet,
      Stockholm, Sweden. anncatrine.eldh@ki.se
FAU - Carlsson, Eva
AU  - Carlsson E
LA  - eng
PT  - Journal Article
DEP - 20100818
PL  - Sweden
TA  - Scand J Caring Sci
JT  - Scandinavian journal of caring sciences
JID - 8804206
MH  - Adult
MH  - Aged
MH  - *Caregivers
MH  - *Employment
MH  - Humans
MH  - *Parents
MH  - Sweden
EDAT- 2010/08/21 06:00
MHDA- 2011/09/02 06:00
CRDT- 2010/08/21 06:00
PHST- 2010/08/21 06:00 [entrez]
PHST- 2010/08/21 06:00 [pubmed]
PHST- 2011/09/02 06:00 [medline]
AID - SCS824 [pii]
AID - 10.1111/j.1471-6712.2010.00824.x [doi]
PST - ppublish
SO  - Scand J Caring Sci. 2011 Jun;25(2):285-93. doi: 10.1111/j.1471-6712.2010.00824.x.
      Epub 2010 Aug 18.


PMID- 20722991
OWN - NLM
STAT- MEDLINE
DCOM- 20110211
LR  - 20120119
IS  - 1447-0756 (Electronic)
IS  - 1341-8076 (Linking)
VI  - 36
IP  - 5
DP  - 2010 Oct
TI  - Polypropylene mesh used for adjuvant reconstructive surgical treatment of
      advanced pelvic organ prolapse.
PG  - 1059-63
LID - 10.1111/j.1447-0756.2010.01267.x [doi]
AB  - AIM: To elucidate the outcome of transvaginal pelvic reconstructive surgery using
      polypropylene mesh (Gynemesh; Ethicon, Somerville, NJ, USA) for patients with
      pelvic organ prolapse (POP) stage III or IV. METHODS: Thirty-nine patients who
      underwent transvaginal pelvic reconstructive surgery from September 2004 through 
      December 2005 were collected and analyzed. All patients underwent pelvic
      reconstructive surgery with anterior and posterior colporrhaphy with Gynemesh
      reinforcement. RESULTS: The average age of the patients was 64.1 years and
      average parity was 3.9. Thirty-four patients had Pelvic Organ Prolapse
      Quantification (POP-Q) stage 0, four patients had stage I, and one patient had
      stage II at a median follow-up time of 18 months postoperatively. The success
      rate was 97.4%. Only one patient (2.6%) had recurrent genital prolapse (stage II)
      postoperatively. Quality of life was evaluated before and after the operations.
      The mean scores on the Urinary Distress Inventory-6 (UDI-6) and Incontinence
      Impact Questionnaire-7 (IIQ-7) were 5.0 +/- 4.6 and 8.7 +/- 6.2 before the
      operation and 3.0 +/- 4.7 and 3.2 +/- 5.6 after the operation, respectively (P = 
      0.03 and 0.01). The complication rate was 10.3 %, including one vaginal mesh
      erosion (2.6%), one dyspareunia (2.6%) and two prolonged bladder drainage (longer
      than 14 days, 5.1%). The mean duration of postoperative bladder drainage was 2.4 
      days and mean postoperative hospital stay was 5.1 days. Neither long-term nor
      major complication was identified. CONCLUSION: Transvaginal pelvic reconstructive
      surgery with polypropylene mesh reinforcement is a safe and effective procedure
      for POP on 1.5 years' follow- up. It also has positive influence on quality of
      life.
CI  - (c) 2010 The Authors. Journal of Obstetrics and Gynaecology Research (c) 2010
      Japan Society of Obstetrics and Gynecology.
FAU - Lin, Tzu-Yin
AU  - Lin TY
AD  - Department of Obstetrics and Gynecology, Branch for Women and Children, Taipei,
      Taiwan.
FAU - Su, Tsung-Hsien
AU  - Su TH
FAU - Huang, Wen-Chu
AU  - Huang WC
LA  - eng
PT  - Journal Article
DEP - 20100817
PL  - Australia
TA  - J Obstet Gynaecol Res
JT  - The journal of obstetrics and gynaecology research
JID - 9612761
RN  - 0 (Polypropylenes)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Patient Satisfaction
MH  - Pelvic Organ Prolapse/*surgery
MH  - Pelvis/*surgery
MH  - Polypropylenes
MH  - Quality of Life
MH  - Reconstructive Surgical Procedures/*instrumentation
MH  - Severity of Illness Index
MH  - *Surgical Mesh
MH  - Treatment Outcome
EDAT- 2010/08/21 06:00
MHDA- 2011/02/12 06:00
CRDT- 2010/08/21 06:00
PHST- 2010/08/21 06:00 [entrez]
PHST- 2010/08/21 06:00 [pubmed]
PHST- 2011/02/12 06:00 [medline]
AID - JOG1267 [pii]
AID - 10.1111/j.1447-0756.2010.01267.x [doi]
PST - ppublish
SO  - J Obstet Gynaecol Res. 2010 Oct;36(5):1059-63. doi:
      10.1111/j.1447-0756.2010.01267.x. Epub 2010 Aug 17.


PMID- 20722080
OWN - NLM
STAT- MEDLINE
DCOM- 20100901
LR  - 20190612
IS  - 1474-547X (Electronic)
IS  - 0140-6736 (Linking)
VI  - 376
IP  - 9740
DP  - 2010 Aug 14
TI  - Medical ethics and the art of cardiovascular medicine.
PG  - 508-9
FAU - Kirkpatrick, James N
AU  - Kirkpatrick JN
FAU - Fields, Anjali V
AU  - Fields AV
FAU - Ferrari, Victor A
AU  - Ferrari VA
LA  - eng
PT  - News
PL  - England
TA  - Lancet
JT  - Lancet (London, England)
JID - 2985213R
SB  - IM
MH  - *Cardiology
MH  - Defibrillators, Implantable
MH  - *Ethics, Medical
MH  - Evidence-Based Medicine
MH  - Heart Failure/therapy
MH  - Heart, Artificial
MH  - Heart-Assist Devices
MH  - Humans
MH  - Quality of Life
EDAT- 2010/08/20 06:00
MHDA- 2010/09/02 06:00
CRDT- 2010/08/20 06:00
PHST- 2010/08/20 06:00 [entrez]
PHST- 2010/08/20 06:00 [pubmed]
PHST- 2010/09/02 06:00 [medline]
AID - S0140-6736(10)61241-X [pii]
AID - 10.1016/s0140-6736(10)61241-x [doi]
PST - ppublish
SO  - Lancet. 2010 Aug 14;376(9740):508-9. doi: 10.1016/s0140-6736(10)61241-x.


PMID- 20721757
OWN - NLM
STAT- MEDLINE
DCOM- 20101210
LR  - 20100819
IS  - 1469-2910 (Electronic)
IS  - 1364-8470 (Linking)
VI  - 17
IP  - 2
DP  - 2010 Aug
TI  - Extreme condition, extreme measures? Compliance, drug resistance, and the control
      of tuberculosis.
PG  - 201-14
LID - 10.1080/13648470.2010.493606 [doi]
AB  - This paper explores the issue of compliance by focusing on the control of
      tuberculosis. In the last ten years, patient compliance in tuberculosis control
      has discursively shifted from 'direct observation' of therapy to more
      patient-centred focus and support drawing on rights-based approaches in dealing
      with health care provision. At the same time, there has been an increased
      international concern with the rise of drug resistant forms of tuberculosis, and 
      how to manage this. This paper looks at these issues and the tensions between
      them, by discussing the shift in discourses around the two and how they relate.
      Drawing on experience from work in Nepal, and its successful tuberculosis control
      programme, it looks at debates around this and how these two arenas have been
      addressed. The rise of increasingly drug resistant forms of tuberculosis has
      stimulated the development of new WHO and other guidelines addressing how to deal
      with this problem. The links between public health, ethics and legal mandate are 
      presented, and the implications of this for controlling transmission of drug
      resistant disease, on the one hand, and the drive for greater patient support
      mechanisms on the other. Looking forwards to uncertain ethical and public health 
      futures, these issues will be mediated by emergent WHO and international
      frameworks.
FAU - Harper, Ian
AU  - Harper I
AD  - University of Edinburgh, Edinburgh, UK. iharper@staffmail.ed.ac.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - Anthropol Med
JT  - Anthropology & medicine
JID - 9709920
RN  - 0 (Antitubercular Agents)
SB  - IM
MH  - Antitubercular Agents/administration & dosage/*therapeutic use
MH  - *Directly Observed Therapy
MH  - Drug Resistance, Bacterial/*drug effects
MH  - Humans
MH  - *Medication Adherence
MH  - Nepal
MH  - Tuberculosis/*drug therapy/microbiology/prevention & control
MH  - World Health Organization
EDAT- 2010/08/20 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/20 06:00
PHST- 2010/08/20 06:00 [entrez]
PHST- 2010/08/20 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 925910649 [pii]
AID - 10.1080/13648470.2010.493606 [doi]
PST - ppublish
SO  - Anthropol Med. 2010 Aug;17(2):201-14. doi: 10.1080/13648470.2010.493606.


PMID- 20721528
OWN - NLM
STAT- MEDLINE
DCOM- 20110218
LR  - 20211020
IS  - 1433-0431 (Electronic)
IS  - 0085-4530 (Linking)
VI  - 39
IP  - 9
DP  - 2010 Sep
TI  - [Clinical pathway for total knee arthroplasty. I: Pathway conception and effect
      on functional quality of results].
PG  - 853-9
LID - 10.1007/s00132-010-1645-x [doi]
AB  - PURPOSE: The aim of the current study was to evaluate patient-centred and
      economic outcomes after introduction of a clinical pathway for total knee
      arthroplasty. METHODS: In a prospective trial two sequential cohorts of patients 
      undergoing total knee arthroplasty were recruited. Baseline treatment was
      surveyed in cohort I and the clinical pathway was developed and evaluated in
      cohort II. Data from WOMAC, EQ-5D as well as partial cost data were collected.
      The study design was ratified by the local Independent Ethics Committee. RESULTS:
      There was an increase in WOMAC score of 39% for cohort I and 35% for cohort II in
      3 months follow-up. Similar results were found for ED-5D with an increase of 30% 
      for cohort I and 25% for cohort II. Partial cost rates could be lowered from 4303
      EUR to 419 EUR. Despite this significant cost saving we were not able to improve 
      the ratio of improvement in quality of life to costs. CONCLUSION: With the aid of
      a clinical pathway the process for implementation of a total knee arthroplasty
      was improved and treatment quality assured.
FAU - Kirschner, S
AU  - Kirschner S
AD  - Orthopadische Klinik, Universitatsklinikum Carl Gustav Carus Dresden, 01307,
      Dresden. Stephan.Kirschner@uniklinikum-dresden.de
FAU - Lutzner, J
AU  - Lutzner J
FAU - Gunther, K P
AU  - Gunther KP
FAU - Gonska, M E
AU  - Gonska ME
FAU - Reinicke, K
AU  - Reinicke K
FAU - Krummenauer, F
AU  - Krummenauer F
LA  - ger
PT  - Journal Article
TT  - Klinischer Behandlungspfad zur Implantation einer Oberflachenknieendoprothese
      (EGON). I: Pfadkonzeption und Effekt auf funktionelle Ergebnisqualitat.
PL  - Germany
TA  - Orthopade
JT  - Der Orthopade
JID - 0331266
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Arthroplasty, Replacement, Knee/economics/*methods
MH  - Cohort Studies
MH  - Cooperative Behavior
MH  - Cost-Benefit Analysis
MH  - Critical Pathways/economics/*organization & administration
MH  - Female
MH  - Germany
MH  - Humans
MH  - Interdisciplinary Communication
MH  - *Knee Prosthesis/economics
MH  - Male
MH  - Middle Aged
MH  - Osteoarthritis, Knee/*surgery
MH  - Outcome and Process Assessment, Health Care/statistics & numerical data
MH  - Postoperative Complications/economics/*etiology
MH  - Prospective Studies
MH  - Quality Assurance, Health Care/economics/organization & administration
MH  - *Quality of Life
EDAT- 2010/08/20 06:00
MHDA- 2011/02/22 06:00
CRDT- 2010/08/20 06:00
PHST- 2010/08/20 06:00 [entrez]
PHST- 2010/08/20 06:00 [pubmed]
PHST- 2011/02/22 06:00 [medline]
AID - 10.1007/s00132-010-1645-x [doi]
PST - ppublish
SO  - Orthopade. 2010 Sep;39(9):853-9. doi: 10.1007/s00132-010-1645-x.


PMID- 20721419
OWN - NLM
STAT- MEDLINE
DCOM- 20101004
LR  - 20190608
IS  - 0104-1169 (Print)
IS  - 0104-1169 (Linking)
VI  - 18
IP  - 3
DP  - 2010 May-Jun
TI  - The attitudes of nurses from an intensive care unit in the face of errors: an
      approach in light of bioethics.
PG  - 324-30
LID - S0104-11692010000300005 [pii]
AB  - This study analyzed the attitudes of nurses concerning the occurrence of errors
      in nursing procedures carried out in an Intensive Care Unit (ICU) based on the
      bioethics framework. This descriptive study with qualitative approach was carried
      out with 14 nurses from a private hospital in the city of Sao Paulo, Brazil.
      Results were analyzed according to Bardins proposal of content analysis. The
      resulting themes were: acknowledging ones fallibility; acknowledging and
      reporting errors; hiding errors. The nurses reports are based on considerations
      through the lens of bioethics: taking responsibility for an error implies
      acknowledging ones own vulnerabilities; acknowledging an error with
      responsibility implies ethical conditions in the relationships among those
      involved; and errors are in the context of a particular environment. This study
      enables re-thinking nursing practice based on bioethics, resorting to the
      analysis of errors focusing on the relationships between those involved.
FAU - De Cassia Pires Coli, Rita
AU  - De Cassia Pires Coli R
AD  - Centro Universitario Sao Camilo, SP, Brazil. rita.coli@uol.com.br
FAU - Dos Anjos, Marcio Fabri
AU  - Dos Anjos MF
FAU - Pereira, Luciane Lucio
AU  - Pereira LL
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - Rev Lat Am Enfermagem
JT  - Revista latino-americana de enfermagem
JID - 9420934
MH  - *Attitude of Health Personnel
MH  - *Bioethical Issues
MH  - *Ethics, Nursing
MH  - Humans
MH  - *Intensive Care Units
MH  - *Medical Errors
EDAT- 2010/08/20 06:00
MHDA- 2010/10/05 06:00
CRDT- 2010/08/20 06:00
PHST- 2009/04/27 00:00 [received]
PHST- 2009/11/16 00:00 [accepted]
PHST- 2010/08/20 06:00 [entrez]
PHST- 2010/08/20 06:00 [pubmed]
PHST- 2010/10/05 06:00 [medline]
AID - S0104-11692010000300005 [pii]
AID - 10.1590/s0104-11692010000300005 [doi]
PST - ppublish
SO  - Rev Lat Am Enfermagem. 2010 May-Jun;18(3):324-30. doi:
      10.1590/s0104-11692010000300005.


PMID- 20720605
OWN - NLM
STAT- MEDLINE
DCOM- 20100929
LR  - 20211203
IS  - 1175-8716 (Electronic)
IS  - 0028-8446 (Linking)
VI  - 123
IP  - 1320
DP  - 2010 Aug 13
TI  - Health, inequality and the politics of genes.
PG  - 67-75
AB  - Research into the possible genetic basis of health inequalities between different
      ethnic or racial groups raises many scientific, ethical and political concerns.
      Proponents of such research point to the possible benefits for marginalised
      groups of understanding genetic influences on health outcomes; opponents indicate
      the potential social costs, citing historical use of Darwinian concepts to
      explain and justify inequalities between different peoples. Many health
      researchers may avoid the subject due to its potential for controversy--e.g. the 
      recent media furore over the so-called 'warrior gene', and its apparent genetic
      explanations for negative health and social statistics among Maori. This article 
      argues for a more nuanced account of the evolutionary history of marginalised
      groups such as Maori, one that accepts the possibility of relevant genetic
      differences between sub-populations, but which also acknowledges genuine ethical 
      and political concerns. Such an account may assist health researchers in
      addressing the politically sensitive subject of 'race' and social inequality.
FAU - Whittle, Patrick M
AU  - Whittle PM
AD  - Department of Philosophy, University of Canterbury, Christchurch, New Zealand.
      patrick.whittle@pg.canterbury.ac.nz
LA  - eng
PT  - Journal Article
DEP - 20100813
PL  - New Zealand
TA  - N Z Med J
JT  - The New Zealand medical journal
JID - 0401067
SB  - IM
MH  - Aggression/physiology
MH  - Alcoholism/genetics
MH  - Cultural Evolution
MH  - Health Services Accessibility/*ethics/*legislation & jurisprudence
MH  - *Health Status Disparities
MH  - Humans
MH  - Life Expectancy
MH  - Melanoma/ethnology
MH  - Native Hawaiian or Other Pacific Islander/*genetics
MH  - New Zealand/epidemiology
MH  - Politics
MH  - Prejudice
MH  - Risk-Taking
MH  - Skin Neoplasms/ethnology
MH  - Social Environment
MH  - Socioeconomic Factors
MH  - Tobacco Use Disorder/genetics
EDAT- 2010/08/20 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/08/20 06:00
PHST- 2010/08/20 06:00 [entrez]
PHST- 2010/08/20 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
PST - epublish
SO  - N Z Med J. 2010 Aug 13;123(1320):67-75.


PMID- 20720214
OWN - NLM
STAT- MEDLINE
DCOM- 20110303
LR  - 20211203
IS  - 1946-6242 (Electronic)
IS  - 1946-6234 (Linking)
VI  - 2
IP  - 45
DP  - 2010 Aug 18
TI  - 360 Degrees of human subjects protections in community-engaged research.
PG  - 45cm23
LID - 10.1126/scitranslmed.3001162 [doi]
AB  - With the introduction of the new National Institutes of Health Roadmap in 2003,
      there has been a growing emphasis on translational research. Translational
      research challenges current human subjects protections guidelines that were
      written in the 1970s and were focused on the protection of the individual
      participant in a clinical drug trial. Community engagement requires a critical
      examination of the range of risks that may arise when communities are both
      participants and partners in research, in order to promote appropriate and
      effective protection of human subjects as individuals and members of communities.
      Given that the principal investigator has ultimate responsibility for ensuring
      the ethical integrity of the research, researchers should be aware of the human
      subjects protections delineated in the federal regulations that must be fulfilled
      and the other entities that can help ensure human subjects protections.
FAU - Ross, Lainie Friedman
AU  - Ross LF
AD  - Department of Pediatrics and MacLean Center for Clinical Medical Ethics,
      University of Chicago, Chicago, IL 60637, USA. lross@uchicago.edu
LA  - eng
GR  - UL1 RR024999/RR/NCRR NIH HHS/United States
GR  - UL1RR024999/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Sci Transl Med
JT  - Science translational medicine
JID - 101505086
SB  - IM
MH  - Community-Based Participatory Research/ethics/*standards
MH  - Human Experimentation/ethics/*standards
MH  - Humans
MH  - Translational Research, Biomedical/ethics/standards
MH  - United States
PMC - PMC4261185
MID - NIHMS644465
EDAT- 2010/08/20 06:00
MHDA- 2011/03/04 06:00
CRDT- 2010/08/20 06:00
PHST- 2010/08/20 06:00 [entrez]
PHST- 2010/08/20 06:00 [pubmed]
PHST- 2011/03/04 06:00 [medline]
AID - 2/45/45cm23 [pii]
AID - 10.1126/scitranslmed.3001162 [doi]
PST - ppublish
SO  - Sci Transl Med. 2010 Aug 18;2(45):45cm23. doi: 10.1126/scitranslmed.3001162.


PMID- 20719537
OWN - NLM
STAT- MEDLINE
DCOM- 20121204
LR  - 20120323
IS  - 1532-8511 (Electronic)
IS  - 1052-3057 (Linking)
VI  - 21
IP  - 3
DP  - 2012 Apr
TI  - Lack of international consensus on ethical aspects of acute stroke trials.
PG  - 200-4
LID - 10.1016/j.jstrokecerebrovasdis.2010.06.008 [doi]
AB  - Acute stroke trials are becoming increasingly multinational. Working toward a
      shared ethical standard for acute stroke research necessitates evaluating the
      degree of consensus among international researchers. We surveyed all 275
      coinvestigators and coordinators who participated in the AbESTT II study
      (evaluating abciximab vs placebo) about their experience with their local
      institutional review board (IRB) or equivalent, as well as, about their personal 
      beliefs regarding the ethical aspects of acute stroke trials. A total of 90
      coinvestigators from 15 different countries responded to our survey. Among the
      IRBs represented by the responding coinvestigators, only 18% allowed surrogate
      consent to be obtained over the phone. Although 52% allowed the participation of 
      subjects with aphasia, only 5% allowed the participation of subjects with
      neglect/hemi-inattention. The National Institutes of Health Stroke Scale score
      was deemed adequate to establish decisional capacity based on language by 62% of 
      the coinvestigators and 36% of the IRBs. A belief that IRB regulations cause
      unnecessary delays and fear in relatives/patients was reported by 67% of
      coinvestigators, and the belief that granting an exemption from informed consent 
      under specific circumstances is appropriate was reported by 41%. There appears to
      be considerable international diversity in the ethical priorities and informed
      consent standards among different IRBs and investigators in stroke research. The 
      stroke community should make an attempt to standardize the consent process used
      in research. Given the critical nature of the time to treatment in stroke care,
      these standards should be integrated into current frameworks of clinical care and
      research. The absence of an ethical consensus can become a barrier to advancing
      stroke treatment internationally.
CI  - Copyright A(c) 2012 National Stroke Association. Published by Elsevier Inc. All
      rights reserved.
FAU - Leira, Enrique C
AU  - Leira EC
AD  - Department of Neurology, Carver College of Medicine, Iowa City, Iowa, USA.
      enrique-leira@uiowa.edu
FAU - Kaldjian, Lauris C
AU  - Kaldjian LC
FAU - Ludwig, Bryan R
AU  - Ludwig BR
FAU - Torner, James C
AU  - Torner JC
FAU - Olalde, Heena M
AU  - Olalde HM
FAU - Hacke, Werner
AU  - Hacke W
FAU - Adams, Harold P Jr
AU  - Adams HP Jr
LA  - eng
PT  - Journal Article
DEP - 20100817
PL  - United States
TA  - J Stroke Cerebrovasc Dis
JT  - Journal of stroke and cerebrovascular diseases : the official journal of National
      Stroke Association
JID - 9111633
SB  - IM
MH  - Acute Disease
MH  - Clinical Trials as Topic/*ethics/methods/*standards
MH  - *Consensus
MH  - Ethics, Medical
MH  - Health Care Surveys/*methods
MH  - Humans
MH  - Internationality
MH  - Patient Selection/ethics
MH  - Stroke/*drug therapy
EDAT- 2010/08/20 06:00
MHDA- 2012/12/10 06:00
CRDT- 2010/08/20 06:00
PHST- 2010/04/17 00:00 [received]
PHST- 2010/06/01 00:00 [revised]
PHST- 2010/06/20 00:00 [accepted]
PHST- 2010/08/20 06:00 [entrez]
PHST- 2010/08/20 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - S1052-3057(10)00147-3 [pii]
AID - 10.1016/j.jstrokecerebrovasdis.2010.06.008 [doi]
PST - ppublish
SO  - J Stroke Cerebrovasc Dis. 2012 Apr;21(3):200-4. doi:
      10.1016/j.jstrokecerebrovasdis.2010.06.008. Epub 2010 Aug 17.


PMID- 20719097
OWN - NLM
STAT- MEDLINE
DCOM- 20101208
LR  - 20100819
IS  - 1488-2159 (Electronic)
IS  - 0709-8936 (Linking)
VI  - 76
DP  - 2010
TI  - Property and privacy paradigms of "marketable spit": an ethical and legal
      counterpart to blood?
PG  - a51
AB  - Major advances in the testing of oral fluid (e.g., saliva) may lead to the
      diagnosis and treatment of previously undiagnosed conditions and may enable
      dentists to manage oral disease more effectively. Such use of another body fluid,
      blood, is already well established. Blood is a complex tissue that has been
      extensively researched and is now used for a wide variety of diagnostic tests. It
      is also regarded as a form of property with ethical and legal dimensions. If
      saliva is to fulfill a similar role, it should perhaps be granted those same
      protections. This paper advances the concept that saliva should be considered a
      form of property, possibly within personal biological materials law. The emerging
      potential for the development of marketable products from oral fluids raises the 
      issue of protecting the research participant's ethical and legal rights. In
      particular, violation of privacy and genetic discrimination may arise from the
      testing of salivary DNA. Respect for autonomy requires that the clinician inform 
      a patient or research participant about his or her rights to property and privacy
      as these may pertain to oral fluid.
FAU - Vernillo, Anthony Thomas
AU  - Vernillo AT
AD  - Department of Oral and Maxillofacial Pathology, Radiology and Medicine, New York 
      University College of Dentistry, New York, NY 10010-4086, USA
FAU - Wolpe, Paul Root
AU  - Wolpe PR
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - J Can Dent Assoc
JT  - Journal (Canadian Dental Association)
JID - 7907605
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Biotechnology/ethics/legislation & jurisprudence
MH  - *Blood
MH  - DNA/analysis
MH  - Diagnostic Techniques and Procedures/ethics
MH  - Humans
MH  - Ownership/*ethics/legislation & jurisprudence
MH  - Patient Rights/*ethics/legislation & jurisprudence
MH  - Personal Autonomy
MH  - Privacy/*legislation & jurisprudence
MH  - *Saliva
EDAT- 2010/08/20 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/20 06:00
PHST- 2010/08/20 06:00 [entrez]
PHST- 2010/08/20 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - J Can Dent Assoc. 2010;76:a51.


PMID- 20719029
OWN - NLM
STAT- MEDLINE
DCOM- 20101012
LR  - 20100819
IS  - 1469-2147 (Electronic)
IS  - 0963-1801 (Linking)
VI  - 19
IP  - 4
DP  - 2010 Oct
TI  - Rural healthcare ethics: no longer the forgotten quarter.
PG  - 510-7
LID - 10.1017/S096318011000040X [doi]
FAU - Nelson, William
AU  - Nelson W
FAU - Greene, Mary Ann
AU  - Greene MA
FAU - West, Alan
AU  - West A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Camb Q Healthc Ethics
JT  - Cambridge quarterly of healthcare ethics : CQ : the international journal of
      healthcare ethics committees
JID - 9208482
SB  - IM
MH  - Delivery of Health Care/*ethics
MH  - Humans
MH  - *Rural Health/trends
MH  - United States
MH  - Urban Health/trends
EDAT- 2010/08/20 06:00
MHDA- 2010/10/13 06:00
CRDT- 2010/08/20 06:00
PHST- 2010/08/20 06:00 [entrez]
PHST- 2010/08/20 06:00 [pubmed]
PHST- 2010/10/13 06:00 [medline]
AID - S096318011000040X [pii]
AID - 10.1017/S096318011000040X [doi]
PST - ppublish
SO  - Camb Q Healthc Ethics. 2010 Oct;19(4):510-7. doi: 10.1017/S096318011000040X.


PMID- 20719026
OWN - NLM
STAT- MEDLINE
DCOM- 20101012
LR  - 20131121
IS  - 1469-2147 (Electronic)
IS  - 0963-1801 (Linking)
VI  - 19
IP  - 4
DP  - 2010 Oct
TI  - What health science students learn from playing a standardized patient in an
      ethics course.
PG  - 481-7
LID - 10.1017/S096318011000037X [doi]
FAU - Haddad, Amy
AU  - Haddad A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Camb Q Healthc Ethics
JT  - Cambridge quarterly of healthcare ethics : CQ : the international journal of
      healthcare ethics committees
JID - 9208482
RN  - 0 (Dermatologic Agents)
RN  - 0 (Teratogens)
RN  - EH28UP18IF (Isotretinoin)
SB  - IM
MH  - Dermatologic Agents/administration & dosage/adverse effects
MH  - Education, Nursing/*standards/trends
MH  - Education, Pharmacy/*standards/trends
MH  - Ethics, Clinical/*education
MH  - Female
MH  - Humans
MH  - Isotretinoin/administration & dosage/adverse effects
MH  - Male
MH  - *Patient Simulation
MH  - Pilot Projects
MH  - Pregnancy
MH  - Pregnancy Complications/chemically induced/prevention & control
MH  - Problem-Based Learning/*methods
MH  - *Students, Nursing
MH  - *Students, Pharmacy
MH  - Teaching/*methods
MH  - Teratogens
MH  - Young Adult
EDAT- 2010/08/20 06:00
MHDA- 2010/10/13 06:00
CRDT- 2010/08/20 06:00
PHST- 2010/08/20 06:00 [entrez]
PHST- 2010/08/20 06:00 [pubmed]
PHST- 2010/10/13 06:00 [medline]
AID - S096318011000037X [pii]
AID - 10.1017/S096318011000037X [doi]
PST - ppublish
SO  - Camb Q Healthc Ethics. 2010 Oct;19(4):481-7. doi: 10.1017/S096318011000037X.


PMID- 20719025
OWN - NLM
STAT- MEDLINE
DCOM- 20101012
LR  - 20100819
IS  - 1469-2147 (Electronic)
IS  - 0963-1801 (Linking)
VI  - 19
IP  - 4
DP  - 2010 Oct
TI  - The unique nature of clinical ethics in allied health pediatrics: implications
      for ethics education.
PG  - 471-80
LID - 10.1017/S0963180110000368 [doi]
FAU - Delany, Clare
AU  - Delany C
FAU - Spriggs, Merle
AU  - Spriggs M
FAU - Fry, Craig L
AU  - Fry CL
FAU - Gillam, Lynn
AU  - Gillam L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Camb Q Healthc Ethics
JT  - Cambridge quarterly of healthcare ethics : CQ : the international journal of
      healthcare ethics committees
JID - 9208482
SB  - IM
MH  - Allied Health Occupations/*education/ethics/standards/trends
MH  - Child
MH  - Decision Making/ethics
MH  - Education, Professional/*methods/standards/trends
MH  - Ethics, Clinical/*education
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Pediatrics/*ethics/standards/trends
MH  - Research/trends
MH  - Teaching/*methods/standards/trends
EDAT- 2010/08/20 06:00
MHDA- 2010/10/13 06:00
CRDT- 2010/08/20 06:00
PHST- 2010/08/20 06:00 [entrez]
PHST- 2010/08/20 06:00 [pubmed]
PHST- 2010/10/13 06:00 [medline]
AID - S0963180110000368 [pii]
AID - 10.1017/S0963180110000368 [doi]
PST - ppublish
SO  - Camb Q Healthc Ethics. 2010 Oct;19(4):471-80. doi: 10.1017/S0963180110000368.


PMID- 20719023
OWN - NLM
STAT- MEDLINE
DCOM- 20101012
LR  - 20161125
IS  - 1469-2147 (Electronic)
IS  - 0963-1801 (Linking)
VI  - 19
IP  - 4
DP  - 2010 Oct
TI  - Teaching military medical ethics: another look at dual loyalty and triage.
PG  - 458-64
LID - 10.1017/S0963180110000344 [doi]
FAU - Gross, Michael L
AU  - Gross ML
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Camb Q Healthc Ethics
JT  - Cambridge quarterly of healthcare ethics : CQ : the international journal of
      healthcare ethics committees
JID - 9208482
SB  - IM
MH  - Education, Medical/*methods/standards
MH  - Ethics, Medical/*education
MH  - Humans
MH  - Military Medicine/*ethics/standards/trends
MH  - *Military Personnel
MH  - *Personnel Loyalty
MH  - Teaching/*methods/standards/trends
MH  - Triage/*ethics/standards
MH  - United Kingdom
MH  - United States
EDAT- 2010/08/20 06:00
MHDA- 2010/10/13 06:00
CRDT- 2010/08/20 06:00
PHST- 2010/08/20 06:00 [entrez]
PHST- 2010/08/20 06:00 [pubmed]
PHST- 2010/10/13 06:00 [medline]
AID - S0963180110000344 [pii]
AID - 10.1017/S0963180110000344 [doi]
PST - ppublish
SO  - Camb Q Healthc Ethics. 2010 Oct;19(4):458-64. doi: 10.1017/S0963180110000344.


PMID- 20719021
OWN - NLM
STAT- MEDLINE
DCOM- 20101012
LR  - 20100819
IS  - 1469-2147 (Electronic)
IS  - 0963-1801 (Linking)
VI  - 19
IP  - 4
DP  - 2010 Oct
TI  - Should empathic development be a priority in biomedical ethics teaching? A
      critical perspective.
PG  - 433-45
LID - 10.1017/S0963180110000320 [doi]
FAU - Maxwell, Bruce
AU  - Maxwell B
FAU - Racine, Eric
AU  - Racine E
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Camb Q Healthc Ethics
JT  - Cambridge quarterly of healthcare ethics : CQ : the international journal of
      healthcare ethics committees
JID - 9208482
SB  - IM
MH  - Affect
MH  - Bioethics/*education
MH  - Character
MH  - Cognition
MH  - Education, Medical/*standards/trends
MH  - *Empathy/ethics
MH  - *Ethics, Medical
MH  - Humans
MH  - Judgment
MH  - *Morals
MH  - Motivation
MH  - Physicians/*ethics/psychology
MH  - Students, Medical/psychology
MH  - Teaching/*standards/trends
EDAT- 2010/08/20 06:00
MHDA- 2010/10/13 06:00
CRDT- 2010/08/20 06:00
PHST- 2010/08/20 06:00 [entrez]
PHST- 2010/08/20 06:00 [pubmed]
PHST- 2010/10/13 06:00 [medline]
AID - S0963180110000320 [pii]
AID - 10.1017/S0963180110000320 [doi]
PST - ppublish
SO  - Camb Q Healthc Ethics. 2010 Oct;19(4):433-45. doi: 10.1017/S0963180110000320.


PMID- 20718963
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20211020
IS  - 1476-069X (Electronic)
IS  - 1476-069X (Linking)
VI  - 9
DP  - 2010 Aug 18
TI  - The ethics of human volunteer studies involving experimental exposure to
      pesticides: unanswered dilemmas.
PG  - 50
LID - 10.1186/1476-069X-9-50 [doi]
AB  - The controversy about the use of data from human volunteer studies involving
      experimental exposure to pesticides as part of regulatory risk assessment has
      been widely discussed, but the complex and interrelated scientific and ethical
      issues remain largely unresolved. This discussion paper, generated by authors who
      comprised a workgroup of the ICOH Scientific Committee on Rural Health, reviews
      the use of human experimental studies in regulatory risk assessment for
      pesticides with a view to advancing the debate as to when, if ever, such studies 
      might be ethically justifiable. The discussion is based on three elements: (a) a 
      review of discussion papers on the topic of human testing of pesticides and the
      positions adopted by regulatory agencies in developed countries; (b) an analysis 
      of published and unpublished studies involving human testing with pesticides,
      both in the peer-reviewed literature and in the JMPR database; and (c)
      application of an ethical analysis to the problem. The paper identifies areas of 
      agreement which include general principles that may provide a starting point on
      which to base criteria for judgements as to the ethical acceptability of such
      studies. However, the paper also highlights ongoing unresolved differences of
      opinion inherent in ethical analysis of contentious issues, which we propose
      should form a starting point for further debate and the development of guidelines
      to achieve better resolution of this matter.
FAU - London, Leslie
AU  - London L
AD  - Centre for Occupational and Environmental Health Research, School of Public
      Health and Family Medicine, University of Cape Town, Cape Town, South Africa.
      leslie.london@uct.ac.za
FAU - Coggon, David
AU  - Coggon D
FAU - Moretto, Angelo
AU  - Moretto A
FAU - Westerholm, Peter
AU  - Westerholm P
FAU - Wilks, Martin F
AU  - Wilks MF
FAU - Colosio, Claudio
AU  - Colosio C
LA  - eng
GR  - MC_U147574248/MRC_/Medical Research Council/United Kingdom
GR  - MC_U147585823/MRC_/Medical Research Council/United Kingdom
GR  - MC_UP_A620_1018/MRC_/Medical Research Council/United Kingdom
GR  - U.1475.00.005.00006.03(74248)/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Review
DEP - 20100818
PL  - England
TA  - Environ Health
JT  - Environmental health : a global access science source
JID - 101147645
RN  - 0 (Pesticides)
SB  - IM
MH  - Biomedical Research/ethics
MH  - Environmental Exposure/*ethics
MH  - *Ethics, Research
MH  - Humans
MH  - Pesticides/*toxicity
PMC - PMC2931486
EDAT- 2010/08/20 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/20 06:00
PHST- 2010/04/15 00:00 [received]
PHST- 2010/08/18 00:00 [accepted]
PHST- 2010/08/20 06:00 [entrez]
PHST- 2010/08/20 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 1476-069X-9-50 [pii]
AID - 10.1186/1476-069X-9-50 [doi]
PST - epublish
SO  - Environ Health. 2010 Aug 18;9:50. doi: 10.1186/1476-069X-9-50.


PMID- 20718935
OWN - NLM
STAT- MEDLINE
DCOM- 20110901
LR  - 20110513
IS  - 1471-6712 (Electronic)
IS  - 0283-9318 (Linking)
VI  - 25
IP  - 2
DP  - 2011 Jun
TI  - Health-illness transition among persons using advanced medical technology at
      home.
PG  - 253-61
LID - 10.1111/j.1471-6712.2010.00820.x [doi]
AB  - This study aimed to elucidate meanings of health-illness transition experiences
      among adult persons using advanced medical technology at home. As an increasing
      number of persons perform self-care while using different sorts of advanced
      medical technology at home, knowledge about health-illness transition experiences
      in this situation may be useful to caregivers in supporting these patients. A
      qualitative design was used. Five women and five men, all of whom performed
      self-care at home, either using long-term oxygen therapy from a ventilator or
      oxygen cylinder, or performing peritoneal or haemodialysis, were interviewed.
      Ethics committee approval was obtained. Informed consent was received from all
      participants, and ethical issues concerning their rights in research were raised.
      The interviews were analysed using a phenomenological hermeneutical methodology, 
      including both an inductive and a deductive structural analysis. This method
      offers possibilities to obtain an increased understanding by uncovering a deeper 
      meaning of lived experiences through interviews transcribed as texts. The
      health-illness transition for adult persons in this context was found to mean a
      learning process of accepting, managing, adjusting and improving daily life with 
      technology, facilitated by realizing the gain from technology at home. Further,
      the meaning of the health-illness transition experience was interpreted as
      contentment with being part of the active and conscious process towards
      transcending into a new state of living, in which the individual and the
      technology were in tune. The healthy transition experience was characterized by
      human growth and becoming. This study elucidates one meaning of health-illness
      transition experiences in relation to the use of advanced medical technology on a
      more generic level, independent of the specific type of technology used. A
      positive attitude towards technology at home facilitates the transition.
CI  - (c) 2010 The Authors. Scandinavian Journal of Caring Sciences (c) 2010 Nordic
      College of Caring Science.
FAU - Fex, Angelika
AU  - Fex A
AD  - Department of Nursing, Health and Culture, University West, Trollhattan, Sweden. 
      angelika.fex@hv.se
FAU - Flensner, Gullvi
AU  - Flensner G
FAU - Ek, Anna-Christina
AU  - Ek AC
FAU - Soderhamn, Olle
AU  - Soderhamn O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100816
PL  - Sweden
TA  - Scand J Caring Sci
JT  - Scandinavian journal of caring sciences
JID - 8804206
MH  - Adult
MH  - Female
MH  - *Home Care Services
MH  - Humans
MH  - Male
MH  - Oxygen Inhalation Therapy/*instrumentation
MH  - Sweden
EDAT- 2010/08/20 06:00
MHDA- 2011/09/02 06:00
CRDT- 2010/08/20 06:00
PHST- 2010/08/20 06:00 [entrez]
PHST- 2010/08/20 06:00 [pubmed]
PHST- 2011/09/02 06:00 [medline]
AID - SCS820 [pii]
AID - 10.1111/j.1471-6712.2010.00820.x [doi]
PST - ppublish
SO  - Scand J Caring Sci. 2011 Jun;25(2):253-61. doi: 10.1111/j.1471-6712.2010.00820.x.
      Epub 2010 Aug 16.


PMID- 20718828
OWN - NLM
STAT- MEDLINE
DCOM- 20120703
LR  - 20211020
IS  - 1755-5949 (Electronic)
IS  - 1755-5930 (Linking)
VI  - 17
IP  - 5
DP  - 2011 Oct
TI  - Genomics and pharmacogenomics of dementia.
PG  - 566-76
LID - 10.1111/j.1755-5949.2010.00189.x [doi]
AB  - Dementia is a major problem of health in developed countries, and a prototypical 
      paradigm of chronic disability, high cost, and social-family burden.
      Approximately, 10-20% of direct costs in this kind of neuropathology are related 
      to pharmacological treatment, with a moderate responder rate below 30% and
      questionable cost-effectiveness. Over 200 different genes have been associated
      with the pathogenesis of dementia. Studies on structural and functional genomics,
      transcriptomics, proteomics and metabolomics have revealed the paramount
      importance of these novel technologies for the understanding of pathogenic
      cascades and the prediction of therapeutic outcomes in dementia. About 10-30% of 
      Western populations are defective in genes of the CYP superfamily. The most
      frequent CYP2D6 variants in the Iberian peninsula are the *1/*1 (57.84%), *1/*4
      (22.78%), *1xN/*1 (6.10%), *4/*4 (2.56%), and *1/*3 (2.01%) genotypes, accounting
      for more than 80% of the population. The frequency of extensive (EMs),
      intermediate (IMs), poor (PMs), and ultra-rapid metabolizers (UMs) is about
      59.51%, 29,78%, 4.46%, and 6.23%, respectively, in the general population, and
      57.76, 31.05%, 5.27%, and 5.90%, respectively, in AD cases. The construction of a
      genetic map integrating the most prevalent CYP2D6+CYP2C19+CYP2C9 polymorphic
      variants in a trigenic cluster yields 82 different haplotype-like profiles, with 
      *1*1-*1*1-*1*1 (25.70%), *1*1-*1*2-*1*2 (10.66%), *1*1-*1*1-*1*1 (10.45%),
      *1*4-*1*1-*1*1 (8.09%), *1*4-*1*2-*1*1 (4.91%), *1*4-*1*1-*1*2 (4.65%), and
      *1*1-*1*3-*1*3 (4.33%), as the most frequent genotypes. Only 26.51% of AD
      patients show a pure 3EM phenotype, 15.29% are 2EM1IM, 2.04% are pure 3IM, 0% are
      pure 3PM, and 0% are 1UM2PM. EMs and IMs are the best responders, and PMs and UMs
      are the worst responders to a combination therapy with cholinesterase inhibitors,
      neuroprotectants, and vasoactive substances. The pharmacogenetic response in AD
      appears to be dependent upon the networking activity of genes involved in drug
      metabolism and genes involved in AD pathogenesis (e.g., APOE). AD patients
      harboring the APOE-4/4 genotypes are the worst responders to conventional
      antidementia drugs. To achieve a mature discipline of pharmacogenomics in CNS
      disorders and dementia it would be convenient to accelerate the following
      processes: (i) to educate physicians and the public on the use of genetic/genomic
      screening in daily clinical practice; (ii) to standardize genetic testing for
      major categories of drugs; (iii) to validate pharmacogenomic information
      according to drug category and pathology; (iv) to regulate ethical, social, and
      economic issues; and (v) to incorporate pharmacogenomic procedures both to drugs 
      in development and drugs on the market in order to optimize therapeutics.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Cacabelos, Ramon
AU  - Cacabelos R
AD  - EuroEspes Biomedical Research Center, Institute for CNS Disorders and Genomic
      Medicine, Bergondo, Coruna, Spain. rcacabelos@euroespes.com
FAU - Martinez-Bouza, Rocio
AU  - Martinez-Bouza R
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100816
PL  - England
TA  - CNS Neurosci Ther
JT  - CNS neuroscience & therapeutics
JID - 101473265
RN  - 0 (Apolipoprotein E4)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP2D6)
SB  - IM
MH  - Animals
MH  - Apolipoprotein E4/genetics
MH  - Cytochrome P-450 CYP2D6/genetics
MH  - Dementia/*diagnosis/*genetics
MH  - Genomics/*methods/trends
MH  - Humans
MH  - Pharmacogenetics/*methods/trends
MH  - Polymorphism, Genetic/genetics
PMC - PMC6493895
EDAT- 2010/08/20 06:00
MHDA- 2012/07/04 06:00
CRDT- 2010/08/20 06:00
PHST- 2010/08/20 06:00 [entrez]
PHST- 2010/08/20 06:00 [pubmed]
PHST- 2012/07/04 06:00 [medline]
AID - CNS189 [pii]
AID - 10.1111/j.1755-5949.2010.00189.x [doi]
PST - ppublish
SO  - CNS Neurosci Ther. 2011 Oct;17(5):566-76. doi: 10.1111/j.1755-5949.2010.00189.x. 
      Epub 2010 Aug 16.


PMID- 20718645
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20100819
IS  - 1536-0539 (Electronic)
IS  - 1536-0288 (Linking)
VI  - 24
IP  - 3
DP  - 2010 Sep
TI  - Research in end-of-life settings: an ethical inquiry.
PG  - 244-50
LID - 10.3109/15360288.2010.493579 [doi]
AB  - A fundamental tension surrounds the ethics of conducting research in vulnerable
      populations, and specifically, research involving patients at or near the
      end-of-life. In Palliative Medicine, these patients' care has historically been
      based on compassion, clinical judgment and experience, and anecdote rather than
      on data generated through high-quality clinical trials. A robust evidence base to
      support clinical practice in the end-of-life setting is lacking. Multiple ethical
      objections to the conduct of research at the end of life have impeded efforts to 
      build such an evidence base. Arguments can be categorized into claims that the
      goals of research conflict with the goals of care; research unduly burdens
      vulnerable patients and families/caregivers; genuine equipoise does not exist;
      and research in the palliative care setting is too difficult. The authors explore
      and respond to these objections, noting the vital importance of research at this 
      stage of the illness trajectory. The authors conclude that barriers to palliative
      care research are surmountable, and, indeed, that the "research imperative" and
      principles laid out in the Belmont Report of 1979 require us to rigorously study 
      clinical interventions used for palliative care patients-so as to provide optimal
      safety and outcomes for present and future patients.
FAU - LeBlanc, Thomas W
AU  - LeBlanc TW
AD  - Division of Medical Oncology, Department of Medicine, Duke University Medical
      Center, Durham, North Carolina 27710, USA.
FAU - Wheeler, Jane L
AU  - Wheeler JL
FAU - Abernethy, Amy P
AU  - Abernethy AP
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Pain Palliat Care Pharmacother
JT  - Journal of pain & palliative care pharmacotherapy
JID - 101125608
SB  - IM
MH  - *Ethics, Medical
MH  - Humans
MH  - Palliative Care/*ethics
MH  - *Research
MH  - Terminal Care/*ethics
MH  - Terminally Ill/*psychology
EDAT- 2010/08/20 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/20 06:00
PHST- 2010/08/20 06:00 [entrez]
PHST- 2010/08/20 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.3109/15360288.2010.493579 [doi]
PST - ppublish
SO  - J Pain Palliat Care Pharmacother. 2010 Sep;24(3):244-50. doi:
      10.3109/15360288.2010.493579.


PMID- 20718285
OWN - NLM
STAT- MEDLINE
DCOM- 20100923
LR  - 20171116
IS  - 1362-3699 (Print)
IS  - 1362-3699 (Linking)
VI  - 26
IP  - 2
DP  - 2010 Apr-Jun
TI  - From Goya to Afghanistan--an essay on the ratio and ethics of medical war
      pictures.
PG  - 124-44
LID - 10.1080/13623699.2010.491386 [doi]
AB  - For centuries pictures of the dead and wounded have been part and parcel of war
      communications. Often the intentions were clear, ranging from medical
      instructions to anti-war protests. The public's response could coincide with or
      diverge from the publisher's intention. Following the invention of photography in
      the nineteenth century, and the subsequent claim of realism, the veracity of
      medical war images became more complex. Analysing and understanding such
      photographs have become an ethical obligation with democratic implications. We
      performed a multidisciplinary analysis of War Surgery (2008), a book containing
      harsh, full-colour photographs of mutilated soldiers from the Iraq and
      Afghanistan wars. Our analysis shows that, within the medical context, this book 
      is a major step forward in medical war communication and documentation. In the
      military context the book can be conceived as an attempt to put matters right
      given the enormous sacrifice some individuals have suffered. For the public, the 
      relationship between the 'reality' and 'truth' of such photographs is ambiguous, 
      because only looking at the photographs without reading the medical context is
      limiting. If the observer is not familiar with medical practice, it is difficult 
      for him to fully assess, signify and acknowledge the value and relevance of this 
      book. We therefore assert the importance of the role of professionals and those
      in the humanities in particular in educating the public and initiating debate.
FAU - van Bergen, Leo
AU  - van Bergen L
AD  - Department of Metamedica, VU University Medical Center, Amsterdam, The
      Netherlands. l.vanbergen@vumc.nl
FAU - de Mare, Heidi
AU  - de Mare H
FAU - Meijman, Frans J
AU  - Meijman FJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - Med Confl Surviv
JT  - Medicine, conflict, and survival
JID - 9612305
SB  - IM
MH  - *Afghan Campaign 2001-
MH  - *Books, Illustrated
MH  - Communication
MH  - Democracy
MH  - Documentation/ethics
MH  - *Ethics, Medical
MH  - Humans
MH  - *Iraq War, 2003-2011
MH  - *Medical Illustration
MH  - *Medicine in the Arts
MH  - Military Medicine/education/ethics
MH  - Military Personnel/education/*psychology
MH  - Multiple Trauma/*psychology/surgery
MH  - Photography/*ethics
MH  - Public Opinion
MH  - Truth Disclosure/ethics
MH  - United States
MH  - Violence/ethics/prevention & control/psychology
EDAT- 2010/08/20 06:00
MHDA- 2010/09/24 06:00
CRDT- 2010/08/20 06:00
PHST- 2010/08/20 06:00 [entrez]
PHST- 2010/08/20 06:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
AID - 10.1080/13623699.2010.491386 [doi]
PST - ppublish
SO  - Med Confl Surviv. 2010 Apr-Jun;26(2):124-44. doi: 10.1080/13623699.2010.491386.


PMID- 20693188
OWN - NLM
STAT- MEDLINE
DCOM- 20110307
LR  - 20211020
IS  - 1740-7753 (Electronic)
IS  - 1740-7745 (Linking)
VI  - 7
IP  - 1 Suppl
DP  - 2010
TI  - Biobanking, consent, and commercialization in international genetics research:
      the Type 1 Diabetes Genetics Consortium.
PG  - S33-45
LID - 10.1177/1740774510373492 [doi]
AB  - BACKGROUND: and PURPOSE: This article describes several ethical, legal, and
      social issues typical of international genetics biobanking, as encountered in the
      Type 1 Diabetes Genetics Consortium (T1DGC). METHODS: By studying the examples
      set and lessons learned from other international biobanking studies and by
      devoting considerable time and resources to identifying, addressing, and
      continually monitoring ethical and regulatory concerns, T1DGC was able to
      minimize the problems reported by some earlier studies. CONCLUSIONS: Several
      important conclusions can be drawn based on the experience in this study: (1)
      Basic international standards for research ethics review and informed consent are
      broadly consistent across developed countries. (2) When consent forms are adapted
      locally and translated into different languages, discrepancies are inevitable and
      therefore require prompt central review and resolution before research is
      initiated. (3) Providing separate 'check-box' consent for different elements of a
      study creates confusion and may not be essential. (4) Creating immortalized cell 
      lines to aid future research is broadly acceptable, both in the US and
      internationally. (5) Imposing some limits on the use of stored samples aids in
      obtaining ethics approvals worldwide. (6) Allowing potential commercial uses of
      donated samples is controversial in some Asian countries. (7) Obtaining
      government approvals can be labor-intensive and time-consuming, and can require
      legal and diplomatic skills.
FAU - Hall, Mark A
AU  - Hall MA
AD  - Division of Public Health Sciences, Wake Forest University Health Sciences,
      Winston-Salem, NC 27157, USA. mhall@wfubmc.edu
FAU - King, Nancy M P
AU  - King NM
FAU - Perdue, Letitia H
AU  - Perdue LH
FAU - Hilner, Joan E
AU  - Hilner JE
FAU - Akolkar, Beena
AU  - Akolkar B
FAU - Greenbaum, Carla J
AU  - Greenbaum CJ
FAU - McKeon, Catherine
AU  - McKeon C
CN  - T1DGC
LA  - eng
GR  - U01 DK062418/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - Clin Trials
JT  - Clinical trials (London, England)
JID - 101197451
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Cell Line
MH  - Data Collection/ethics
MH  - Diabetes Mellitus, Type 1/*genetics
MH  - *Ethics, Research
MH  - Humans
MH  - Informed Consent/*ethics
MH  - *Internationality
MH  - Tissue Banks/*ethics
PMC - PMC2917846
IR  - Greenbaum C
FIR - Greenbaum, Carla
IR  - Hall M
FIR - Hall, Mark
IR  - Hilner J
FIR - Hilner, Joan
IR  - Howell S
FIR - Howell, Simon
IR  - King N
FIR - King, Nancy
IR  - McKeon C
FIR - McKeon, Catherine
IR  - Mehra N
FIR - Mehra, Narinder
IR  - Spinas G
FIR - Spinas, Giatgen
IR  - Thomson E
FIR - Thomson, Elizabeth
IR  - Van der Auwera B
FIR - Van der Auwera, Bart
EDAT- 2010/08/20 06:00
MHDA- 2011/03/08 06:00
CRDT- 2010/08/10 06:00
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/20 06:00 [pubmed]
PHST- 2011/03/08 06:00 [medline]
AID - 7/1_suppl/S33 [pii]
AID - 10.1177/1740774510373492 [doi]
PST - ppublish
SO  - Clin Trials. 2010;7(1 Suppl):S33-45. doi: 10.1177/1740774510373492.


PMID- 20717791
OWN - NLM
STAT- MEDLINE
DCOM- 20101206
LR  - 20211020
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Linking)
VI  - 666
DP  - 2010
TI  - Preclinical methods for the evaluation of periodontal regeneration in vivo.
PG  - 285-307
LID - 10.1007/978-1-60761-820-1_18 [doi]
AB  - For the determination of key factors or devices that promote periodontal
      regeneration, preclinical investigations using in vivo animal models are critical
      for evaluating the biological responses before human clinical trial testing. In
      this chapter, we provide an overview on the commonly used preclinical animals for
      the study of reconstructive procedures to promote bone and soft tissue repair of 
      tooth-supporting periodontal defects. Steps are provided on the animal management
      for evaluation of outcome measures using descriptive histology, histomorphometry,
      three-dimensional imaging, and safety assessments. The use of these key measures 
      of periodontal regeneration should aid investigators in the selection of
      appropriate surrogate endpoints to be utilized in the clinical arena, which are
      not practical or ethical in humans. These methods will prepare investigators and 
      assist them in identifying endpoints that can then be adapted to human clinical
      trial planning.
FAU - Seol, Yang-Jo
AU  - Seol YJ
AD  - Department Periodontics and Oral Medicine, School of Dentistry, University of
      Michigan, Ann Arbor, MI, USA.
FAU - Pellegrini, Gaia
AU  - Pellegrini G
FAU - Franco, Lea M
AU  - Franco LM
FAU - Chang, Po-Chun
AU  - Chang PC
FAU - Park, Chan Ho
AU  - Park CH
FAU - Giannobile, William V
AU  - Giannobile WV
LA  - eng
GR  - R01 DE013397/DE/NIDCR NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
SB  - IM
MH  - Animals
MH  - Dogs
MH  - Guided Tissue Regeneration, Periodontal/*methods
MH  - Humans
MH  - Immunohistochemistry
MH  - Models, Biological
MH  - Periodontal Diseases/metabolism/*surgery
MH  - Rats
PMC - PMC5839659
MID - NIHMS918650
EDAT- 2010/08/19 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/19 06:00
PHST- 2010/08/19 06:00 [entrez]
PHST- 2010/08/19 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1007/978-1-60761-820-1_18 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2010;666:285-307. doi: 10.1007/978-1-60761-820-1_18.


PMID- 20717156
OWN - NLM
STAT- MEDLINE
DCOM- 20100830
LR  - 20211020
IS  - 1471-0064 (Electronic)
IS  - 1471-0056 (Linking)
VI  - 11
IP  - 9
DP  - 2010 Sep
TI  - The ethics of using transgenic non-human primates to study what makes us human.
PG  - 658-62
LID - 10.1038/nrg2864 [doi]
AB  - A flood of comparative genomic data is resulting in the identification of human
      lineage-specific (HLS) sequences. As apes are our closest evolutionary relatives,
      transgenic introduction of HLS sequences into these species has the greatest
      potential to produce 'humanized' phenotypes and also to illuminate the functions 
      of these sequences. We argue that such transgenic apes would also be more likely 
      than other species to experience harm from such research, which renders such
      studies ethically unacceptable in apes and justifies regulatory barriers between 
      these species and other non-human primates for HLS transgenic research.
FAU - Coors, Marilyn E
AU  - Coors ME
AD  - Department of Psychiatry and Center for Bioethics and Humanities, School of
      Medicine, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado
      80045, USA. Marilyn.Coors@ucdenver.edu
FAU - Glover, Jacqueline J
AU  - Glover JJ
FAU - Juengst, Eric T
AU  - Juengst ET
FAU - Sikela, James M
AU  - Sikela JM
LA  - eng
GR  - R01-DA029258/DA/NIDA NIH HHS/United States
GR  - P50 HG003390-05S1/HG/NHGRI NIH HHS/United States
GR  - R01-AA11853/AA/NIAAA NIH HHS/United States
GR  - R01-MH081203/MH/NIMH NIH HHS/United States
GR  - P50 HG003390-05S2/HG/NHGRI NIH HHS/United States
GR  - R01 MH081203-01A2/MH/NIMH NIH HHS/United States
GR  - P60 DA011015-12/DA/NIDA NIH HHS/United States
GR  - R01 MH081203-02/MH/NIMH NIH HHS/United States
GR  - 5P60DA011015/DA/NIDA NIH HHS/United States
GR  - P50 HG003390-04S1/HG/NHGRI NIH HHS/United States
GR  - R01 AA011853-11/AA/NIAAA NIH HHS/United States
GR  - P50 HG003390-03/HG/NHGRI NIH HHS/United States
GR  - R01 DA029258-01/DA/NIDA NIH HHS/United States
GR  - P50 HG003390-04/HG/NHGRI NIH HHS/United States
GR  - R01 DA029258/DA/NIDA NIH HHS/United States
GR  - R01 AA011853-12/AA/NIAAA NIH HHS/United States
GR  - P60 DA011015/DA/NIDA NIH HHS/United States
GR  - R01 AA011853/AA/NIAAA NIH HHS/United States
GR  - R01 MH081203/MH/NIMH NIH HHS/United States
GR  - P50 HG003390/HG/NHGRI NIH HHS/United States
GR  - P50 HG003390-05/HG/NHGRI NIH HHS/United States
GR  - P60 DA011015-11A1/DA/NIDA NIH HHS/United States
GR  - R01 AA011853-12S1/AA/NIAAA NIH HHS/United States
GR  - P50-HG03390/HG/NHGRI NIH HHS/United States
GR  - P50 HG003390-03S1/HG/NHGRI NIH HHS/United States
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - England
TA  - Nat Rev Genet
JT  - Nature reviews. Genetics
JID - 100962779
SB  - IM
MH  - Animals
MH  - Animals, Genetically Modified
MH  - Biomedical Research/*ethics
MH  - Genetic Techniques/*ethics
MH  - Humans
MH  - Primates/*genetics
PMC - PMC2995325
MID - NIHMS253472
EDAT- 2010/08/19 06:00
MHDA- 2010/08/31 06:00
CRDT- 2010/08/19 06:00
PHST- 2010/08/19 06:00 [entrez]
PHST- 2010/08/19 06:00 [pubmed]
PHST- 2010/08/31 06:00 [medline]
AID - nrg2864 [pii]
AID - 10.1038/nrg2864 [doi]
PST - ppublish
SO  - Nat Rev Genet. 2010 Sep;11(9):658-62. doi: 10.1038/nrg2864.


PMID- 20716825
OWN - NLM
STAT- MEDLINE
DCOM- 20101220
LR  - 20130418
IS  - 0971-5916 (Print)
IS  - 0971-5916 (Linking)
VI  - 132
DP  - 2010 Aug
TI  - Ethical considerations in developing a national vaccine policy.
PG  - 226-7
FAU - Bhan, Anant
AU  - Bhan A
LA  - eng
PT  - Comment
PT  - Letter
PL  - India
TA  - Indian J Med Res
JT  - The Indian journal of medical research
JID - 0374701
RN  - 0 (Vaccines)
SB  - IM
CON - Indian J Med Res. 2010 May;131:617-28. PMID: 20516532
MH  - *Evidence-Based Medicine
MH  - Health Planning Guidelines
MH  - *Health Policy
MH  - Humans
MH  - Immunization Programs/*ethics/*methods
MH  - India
MH  - *Vaccines
EDAT- 2010/08/19 06:00
MHDA- 2010/12/21 06:00
CRDT- 2010/08/19 06:00
PHST- 2010/08/19 06:00 [entrez]
PHST- 2010/08/19 06:00 [pubmed]
PHST- 2010/12/21 06:00 [medline]
PST - ppublish
SO  - Indian J Med Res. 2010 Aug;132:226-7.


PMID- 20716337
OWN - NLM
STAT- MEDLINE
DCOM- 20101028
LR  - 20211020
IS  - 1824-7288 (Electronic)
IS  - 1720-8424 (Linking)
VI  - 36
DP  - 2010 Aug 17
TI  - The European paediatric legislation: benefits and perspectives.
PG  - 56
LID - 10.1186/1824-7288-36-56 [doi]
AB  - BACKGROUND: The lack of availability of appropriate medicines for children is an 
      extensive and well known problem. Paediatricians and Physicians who take care of 
      the paediatric population are primarily exposed to cope with this negative
      situation very often as more than half of the children are prescribed off-label
      or unlicensed medicines. DISCUSSION: Medicinal products used to treat this
      population should be subjected to ethical research of high quality and be
      explicitly authorized for use in children as it happens in adults. For that
      reason, and following the US experience, the European Paediatric Regulation has
      been amended in January 2007 by the European Commission. The objective of the
      Paediatric Regulation is to improve the development of high quality and ethically
      researched medicines for children aged 0 to 17 years, to facilitate the
      availability of information on the use of medicines for children, without
      subjecting children to unnecessary trials, or delaying the authorization of
      medicines for use in adults. SUMMARY: The Paediatric Regulation is dramatically
      changing the regulatory environment for paediatric medicines in Europe and is
      fuelling an increased number of clinical trials in the paediatric population.
      Nevertheless, there are some risks and pitfalls that need to be anticipated and
      controlled in order to ensure that children will ultimately benefit from this
      European initiative.
FAU - Rocchi, Francesca
AU  - Rocchi F
AD  - Ufficio Informazione e Comunicazione - Agenzia Italiana del Farmaco (AIFA), Via
      del Tritone, 181 - 00187 Roma, Italy. f.rocchi@aifa.gov.it
FAU - Paolucci, Paolo
AU  - Paolucci P
FAU - Ceci, Adriana
AU  - Ceci A
FAU - Rossi, Paolo
AU  - Rossi P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20100817
PL  - England
TA  - Ital J Pediatr
JT  - Italian journal of pediatrics
JID - 101510759
RN  - 0 (Drugs, Investigational)
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Adolescent
MH  - Biomedical Research/*legislation & jurisprudence
MH  - Child
MH  - Child, Preschool
MH  - *Drugs, Investigational
MH  - Europe
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Legislation, Drug/*organization & administration
MH  - Pediatrics/*legislation & jurisprudence
MH  - Pharmaceutical Preparations
PMC - PMC2933611
EDAT- 2010/08/19 06:00
MHDA- 2010/10/29 06:00
CRDT- 2010/08/19 06:00
PHST- 2010/06/30 00:00 [received]
PHST- 2010/08/17 00:00 [accepted]
PHST- 2010/08/19 06:00 [entrez]
PHST- 2010/08/19 06:00 [pubmed]
PHST- 2010/10/29 06:00 [medline]
AID - 1824-7288-36-56 [pii]
AID - 10.1186/1824-7288-36-56 [doi]
PST - epublish
SO  - Ital J Pediatr. 2010 Aug 17;36:56. doi: 10.1186/1824-7288-36-56.


PMID- 20716096
OWN - NLM
STAT- MEDLINE
DCOM- 20110222
LR  - 20220409
IS  - 1365-2923 (Electronic)
IS  - 0308-0110 (Linking)
VI  - 44
IP  - 9
DP  - 2010 Sep
TI  - A medical ethical reasoning model and its contributions to medical education.
PG  - 864-873
LID - 10.1111/j.1365-2923.2010.03722.x [doi]
AB  - OBJECTIVES: Ethical reasoning in medicine is not well understood and medical
      educators often find it difficult to justify what and how they teach and assess
      in medical ethics. To facilitate the development of moral values and professional
      conduct, a model of ethical reasoning was created. The purposes of this paper are
      to describe the ethical reasoning model and to indicate how it can be used to
      foster moral and ethical behaviours. METHODS: The ethical reasoning model was
      created from information derived from two sources: (i) an examination of
      different ethical models described in the literature, and (ii) think-aloud
      interviews with ethical experts in Taiwan and Canada. All the components and
      cognitive steps used by experts in ethical decision making were extracted and
      categorised. Interview subjects consisted of 16 voluntary ethics experts. The
      ethical reasoning models reported in the literature were divided into two groups 
      according to whether they were justification-based or task-based models. Neither 
      of the two types represented the 'whole picture' of ethical reasoning in
      medicine. This analysis enabled us to identify five universal cognitive steps and
      the gaps between 'logical decision' and 'action'. RESULTS: The think-aloud
      interviews verified the multi-dimensional components or steps used by experts
      when resolving ethical problems. The resulting model, designated the Medical
      Ethical Reasoning (MER) Model, reflects interactions within three domains:
      medical and ethical knowledge; cognitive reasoning processes, and attitude.
      CONCLUSIONS: The MER Model accurately reflects how doctors resolve ethical
      dilemmas and is seen to be helpful in identifying what and how educators should
      teach and assess in ethical reasoning. The model can also serve as a
      communication framework for curricular design. A 'humane' doctor is competent in 
      providing quality, ethical patient care. Making an appropriate ethical decision
      is the foundation for subsequent ethical behaviours. By contrast with the
      abundant evidence cited in previous research describing how doctors solve medical
      problems, there is little empirical evidence indicating how doctors make
      appropriate ethical decisions. Thus, the cognition of ethical reasoning in
      medicine is not well understood. This paper represents a step towards overcoming 
      this problem.
FAU - Tsai, Tsuen-Chiuan
AU  - Tsai TC
AD  - Department of Paediatrics, E-Da Hospital, Jiau-Shu Tsuen, Yanchao Township,
      Kaohsiung County, TaiwanDepartment of Chinese Medicine, I-Shou University College
      of Medicine, Jiau-Shu Tsuen, Yanchao Township, Kaohsiung County, 82445
      TaiwanDepartment of Health Care Administration, I-Shou University College of
      Medicine, Jiau-Shu Tsuen, Yanchao Township, Kaohsiung County, Taiwan.
FAU - Harasym, Peter H
AU  - Harasym PH
AD  - Department of Paediatrics, E-Da Hospital, Jiau-Shu Tsuen, Yanchao Township,
      Kaohsiung County, TaiwanDepartment of Chinese Medicine, I-Shou University College
      of Medicine, Jiau-Shu Tsuen, Yanchao Township, Kaohsiung County, 82445
      TaiwanDepartment of Health Care Administration, I-Shou University College of
      Medicine, Jiau-Shu Tsuen, Yanchao Township, Kaohsiung County, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Med Educ
JT  - Medical education
JID - 7605655
SB  - IM
CIN - Med Educ. 2010 Sep;44(9):851-2. PMID: 20716094
MH  - Attitude of Health Personnel
MH  - Decision Making/*ethics
MH  - Education, Medical/*ethics/methods
MH  - Ethics, Medical/*education
MH  - Humans
MH  - Models, Theoretical
MH  - Problem Solving/*ethics
EDAT- 2010/08/19 06:00
MHDA- 2011/02/23 06:00
CRDT- 2010/08/19 06:00
PHST- 2010/08/19 06:00 [entrez]
PHST- 2010/08/19 06:00 [pubmed]
PHST- 2011/02/23 06:00 [medline]
AID - 10.1111/j.1365-2923.2010.03722.x [doi]
PST - ppublish
SO  - Med Educ. 2010 Sep;44(9):864-873. doi: 10.1111/j.1365-2923.2010.03722.x.


PMID- 20716094
OWN - NLM
STAT- MEDLINE
DCOM- 20110222
LR  - 20170502
IS  - 1365-2923 (Electronic)
IS  - 0308-0110 (Linking)
VI  - 44
IP  - 9
DP  - 2010 Sep
TI  - Balancing ethical reasoning and emotional sensibility.
PG  - 851-852
LID - 10.1111/j.1365-2923.2010.03764.x [doi]
FAU - Macneill, Paul Ulhas
AU  - Macneill PU
AD  - Singapore.
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - England
TA  - Med Educ
JT  - Medical education
JID - 7605655
SB  - IM
CON - Med Educ. 2010 Sep;44(9):864-73. PMID: 20716096
MH  - Bioethics/*education
MH  - *Emotions
MH  - Humans
MH  - Problem Solving/*ethics
EDAT- 2010/08/19 06:00
MHDA- 2011/02/23 06:00
CRDT- 2010/08/19 06:00
PHST- 2010/08/19 06:00 [entrez]
PHST- 2010/08/19 06:00 [pubmed]
PHST- 2011/02/23 06:00 [medline]
AID - 10.1111/j.1365-2923.2010.03764.x [doi]
PST - ppublish
SO  - Med Educ. 2010 Sep;44(9):851-852. doi: 10.1111/j.1365-2923.2010.03764.x.


PMID- 20715739
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20220318
IS  - 0310-057X (Print)
IS  - 0310-057X (Linking)
VI  - 38
IP  - 4
DP  - 2010 Jul
TI  - Healthcare utilisation among patients discharged from hospital after intensive
      care.
PG  - 732-9
AB  - Surviving critical illness can be life-changing and presents new healthcare
      challenges for patients after hospital discharge. This feasibility study aimed to
      examine healthcare service utilisation for patients discharged from hospital
      after intensive care unit stay. Following Ethics Committee approval, patients
      aged 18 years and older were recruited over three months. Those admitted after
      cardiac surgery, discharged to another facility or against medical advice were
      excluded. Patients were informed of the study by post and followed-up by
      telephone at two and six months after discharge. General practitioners were also 
      contacted (44% responded). Among 187 patients discharged from hospital, 11 died, 
      25 declined to participate and 39 could not be contacted. For 112 patients (60%) 
      who completed a survey, the majority (82%) went home from hospital and were cared
      for by their partner (53%). More than half of the patients (58%) reported taking 
      the same number of medications after intensive care unit stay but 30% took more
      (P = 0.023). While there was no change in the number of visits to the general
      practitioner for 64% of patients, 29% reported an increase after intensive care
      unit stay. At six months, 40% of responders who were not retired were unemployed.
      Discharge summary surveys revealed 39 general practitioners (71%) were satisfied 
      with details of ongoing healthcare needs. Twenty-one general practitioners wrote 
      comments: 10 reported insufficient information about ongoing needs/rehabilitation
      and two reported no mention of intensive care unit stay. Survivors of critical
      illness had increased healthcare needs and despite most returning home, had a low
      workforce participation rate. This requires further investigation to maximise the
      benefits of survival from critical illness.
FAU - Williams, T A
AU  - Williams TA
AD  - Intensive Care Unit, Royal Perth Hospital, Perth, Western Australia, Australia.
      teresa.williams@curtin.edu.au
FAU - Leslie, G D
AU  - Leslie GD
FAU - Brearley, L
AU  - Brearley L
FAU - Dobb, G J
AU  - Dobb GJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Anaesth Intensive Care
JT  - Anaesthesia and intensive care
JID - 0342017
SB  - IM
MH  - Adult
MH  - Aged
MH  - Critical Illness/rehabilitation
MH  - Data Collection
MH  - Employment/statistics & numerical data
MH  - Family Practice/statistics & numerical data
MH  - Female
MH  - Follow-Up Studies
MH  - Health Services/*statistics & numerical data
MH  - Health Services Needs and Demand/*statistics & numerical data
MH  - Humans
MH  - Intensive Care Units/statistics & numerical data
MH  - Male
MH  - Middle Aged
MH  - Office Visits/*statistics & numerical data
MH  - Patient Discharge
MH  - Western Australia
MH  - Young Adult
EDAT- 2010/08/19 06:00
MHDA- 2010/09/16 06:00
CRDT- 2010/08/19 06:00
PHST- 2010/08/19 06:00 [entrez]
PHST- 2010/08/19 06:00 [pubmed]
PHST- 2010/09/16 06:00 [medline]
AID - 20090848 [pii]
AID - 10.1177/0310057X1003800417 [doi]
PST - ppublish
SO  - Anaesth Intensive Care. 2010 Jul;38(4):732-9. doi: 10.1177/0310057X1003800417.


PMID- 20714932
OWN - NLM
STAT- MEDLINE
DCOM- 20110207
LR  - 20211020
IS  - 1573-2665 (Electronic)
IS  - 0141-8955 (Linking)
VI  - 33
IP  - Suppl 2
DP  - 2010 Oct
TI  - Initial evaluation of a biochemical cystic fibrosis newborn screening by
      sequential analysis of immunoreactive trypsinogen and pancreatitis-associated
      protein (IRT/PAP) as a strategy that does not involve DNA testing in a Northern
      European population.
PG  - S263-71
LID - 10.1007/s10545-010-9174-7 [doi]
AB  - BACKGROUND: Ethical concerns and disadvantages of newborn screening (NBS) for
      cystic fibrosis (CF) related to genetic testing have raised controversies and
      impeded implementation of CF NBS in some countries. In the present study, we used
      a prospective and sequential immunoreactive trypsinogene
      (IRT)/pancreatitis-associated protein (PAP) strategy, with IRT as first and PAP
      as second tier, and validated this biochemical approach against the widely used
      IRT/DNA protocol in a population-based NBS study in southwest Germany. METHODS:
      Prospective quantitation of PAP and genetic analysis for the presence of four
      mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene 
      most prevalent in southwest Germany (F508del, R553X, G551D, G542X) were performed
      in all newborns with IRT > 99.0th percentile. NBS was rated positive when either 
      PAP was >/=1.0 ng/mL and/or at least one CFTR mutation was detected. In addition,
      IRT > 99.9th percentile was also considered a positive rating. Positive rating
      led to referral to a CF centre for testing of sweat Cl(-) concentration.
      FINDINGS: Out of 73,759 newborns tested, 98 (0.13%) were positive with IRT/PAP
      and 56 (0.08%) with IRT/DNA. After sweat testing of 135 CF NBS-positive infants, 
      13 were diagnosed with CF. Detection rates were similar for both IRT/PAP and
      IRT/DNA. One of the 13 diagnosed CF newborns had a PAP concentration <1.0 ng/mL. 
      CONCLUSIONS: Sequential measurement of IRT/PAP provides good sensitivity and
      specificity and allows reliable and cost-effective CF NBS which circumvents the
      necessity of genetic testing with its inherent ethical problems.
FAU - Sommerburg, Olaf
AU  - Sommerburg O
AD  - Division of Paediatric Pulmonology & Allergy and Cystic Fibrosis Center,
      Department of Paediatrics III, University of Heidelberg, Im Neuenheimer Feld 430,
      Heidelberg, Germany. olaf.sommerburg@med.uni-heidelberg.de
FAU - Lindner, Martin
AU  - Lindner M
FAU - Muckenthaler, Martina
AU  - Muckenthaler M
FAU - Kohlmueller, Dirk
AU  - Kohlmueller D
FAU - Leible, Svenja
AU  - Leible S
FAU - Feneberg, Reinhard
AU  - Feneberg R
FAU - Kulozik, Andreas E
AU  - Kulozik AE
FAU - Mall, Marcus A
AU  - Mall MA
FAU - Hoffmann, Georg F
AU  - Hoffmann GF
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100817
PL  - United States
TA  - J Inherit Metab Dis
JT  - Journal of inherited metabolic disease
JID - 7910918
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Biomarkers)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (CFTR protein, human)
RN  - 0 (Chlorides)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Pancreatitis-Associated Proteins)
RN  - 0 (REG3A protein, human)
RN  - 126880-72-6 (Cystic Fibrosis Transmembrane Conductance Regulator)
RN  - 9002-08-8 (Trypsinogen)
SB  - IM
MH  - Antigens, Neoplasm/*blood
MH  - Biomarkers/blood
MH  - Biomarkers, Tumor/*blood
MH  - Chlorides/analysis
MH  - Cystic Fibrosis/blood/*diagnosis/genetics
MH  - Cystic Fibrosis Transmembrane Conductance Regulator/genetics
MH  - *Enzyme-Linked Immunosorbent Assay
MH  - Genetic Testing
MH  - Germany
MH  - Humans
MH  - Infant, Newborn
MH  - Lectins, C-Type/*blood
MH  - Mutation
MH  - Neonatal Screening/*methods
MH  - Pancreatitis-Associated Proteins
MH  - Predictive Value of Tests
MH  - Program Evaluation
MH  - Prospective Studies
MH  - Sensitivity and Specificity
MH  - Sweat/chemistry
MH  - Trypsinogen/*blood
EDAT- 2010/08/18 06:00
MHDA- 2011/02/08 06:00
CRDT- 2010/08/18 06:00
PHST- 2010/03/08 00:00 [received]
PHST- 2010/07/08 00:00 [accepted]
PHST- 2010/07/07 00:00 [revised]
PHST- 2010/08/18 06:00 [entrez]
PHST- 2010/08/18 06:00 [pubmed]
PHST- 2011/02/08 06:00 [medline]
AID - 10.1007/s10545-010-9174-7 [doi]
PST - ppublish
SO  - J Inherit Metab Dis. 2010 Oct;33(Suppl 2):S263-71. doi:
      10.1007/s10545-010-9174-7. Epub 2010 Aug 17.


PMID- 20714807
OWN - NLM
STAT- MEDLINE
DCOM- 20120614
LR  - 20120227
IS  - 1573-6814 (Electronic)
IS  - 1389-9333 (Linking)
VI  - 13
IP  - 1
DP  - 2012 Mar
TI  - A review of the International Atomic Energy Agency (IAEA) international standards
      for tissue banks.
PG  - 15-25
LID - 10.1007/s10561-010-9215-3 [doi]
AB  - The IAEA International Standards for Tissue Banks published in 2003 were based on
      the Standards then currently in use in the USA and the European Union, among
      others, and reflect the best practices associated with the operation of a tissue 
      bank. They cover legal, ethical and regulatory controls as well as requirements
      and procedures from donor selection and tissue retrieval to processing and
      distribution of finished tissue for clinical use. The application of these
      standards allows tissue banks to operate with the current good tissue practice,
      thereby providing grafts of high quality that satisfy the national and
      international demand for safe and biologically useful grafts. The objective of
      this article is to review the IAEA Standards and recommend new topics that could 
      improve the current version.
FAU - Morales Pedraza, Jorge
AU  - Morales Pedraza J
AD  - IAEA Senior Project Manager, Vienna, Austria. jmorales47@hotmail.com
FAU - Lobo Gajiwala, Astrid
AU  - Lobo Gajiwala A
FAU - Martinez Pardo, Maria Esther
AU  - Martinez Pardo ME
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100817
PL  - Netherlands
TA  - Cell Tissue Bank
JT  - Cell and tissue banking
JID - 100965121
SB  - IM
MH  - Advisory Committees
MH  - Humans
MH  - International Agencies/*standards
MH  - *Internationality
MH  - *Nuclear Energy
MH  - Tissue Banks/*standards
MH  - Tissue Donors
EDAT- 2010/08/18 06:00
MHDA- 2012/06/15 06:00
CRDT- 2010/08/18 06:00
PHST- 2009/11/16 00:00 [received]
PHST- 2010/08/04 00:00 [accepted]
PHST- 2010/08/18 06:00 [entrez]
PHST- 2010/08/18 06:00 [pubmed]
PHST- 2012/06/15 06:00 [medline]
AID - 10.1007/s10561-010-9215-3 [doi]
PST - ppublish
SO  - Cell Tissue Bank. 2012 Mar;13(1):15-25. doi: 10.1007/s10561-010-9215-3. Epub 2010
      Aug 17.


PMID- 20714785
OWN - NLM
STAT- MEDLINE
DCOM- 20110613
LR  - 20211020
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 22
IP  - 4
DP  - 2010 Dec
TI  - The presence of ethics programs in critical access hospitals.
PG  - 267-74
LID - 10.1007/s10730-010-9134-5 [doi]
AB  - The purpose of this study was to assess the presence of ethics committees in
      rural critical access hospitals across the United States. Several studies have
      investigated the presence of ethics committees in rural health care facilities.
      The limitation of these studies is in the definition of 'rural hospital' and a
      regional or state focus. These limitations have created large variations in the
      study findings. In this nation-wide study we used the criteria of a critical
      access hospital (CAH), as defined by the Medicare Rural Hospital Flexibility
      Program (Flex Program, 2007), to bring consistency and clarity to the assessment 
      of the presence of ethics committees in rural hospitals. The Flex Monitoring Team
      conducted a national telephone survey of 381 CAH administrators throughout the
      United States. The survey covered a wide variety of questions concerning
      hospitals' community benefit, impact activities, and whether the hospital had a
      formally established an ethics committee. About 230 (60%) of the respondents
      indicated they had a formally established ethics committee or ethics consultation
      program at their CAH. The prevalence of ethics committees declined as the CAH
      location became increasingly rural along a rural-urban continuum. Unlike CAHs,
      all rural Department of Veterans Affairs Medical Centers have ethics committees. 
      The results of this study provide an understanding of the limited presence of
      ethics committee in rural America and the need to consider new approaches for
      providing ethics assistance. A virtual ethics committee network may be the most
      efficient and effective way of providing rural hospitals access to a
      knowledgeable ethics committee or consultant.
FAU - Nelson, William A
AU  - Nelson WA
AD  - Community and Family Medicine and The Dartmouth Institute for Health Policy and
      Clinical Practice, Dartmouth Medical School, 46 Centerra Parkway, Lebanon,
      Hanover, NH 03755, USA. william.a.nelson@dartmouth.edu
FAU - Rosenberg, Marie-Claire
AU  - Rosenberg MC
FAU - Mackenzie, Todd
AU  - Mackenzie T
FAU - Weeks, William B
AU  - Weeks WB
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - Data Collection
MH  - Emergency Service, Hospital/*ethics
MH  - Ethics Committees, Clinical/*statistics & numerical data
MH  - Health Services Accessibility
MH  - Hospitals, Rural
MH  - Humans
MH  - United States
EDAT- 2010/08/18 06:00
MHDA- 2011/06/15 06:00
CRDT- 2010/08/18 06:00
PHST- 2010/08/18 06:00 [entrez]
PHST- 2010/08/18 06:00 [pubmed]
PHST- 2011/06/15 06:00 [medline]
AID - 10.1007/s10730-010-9134-5 [doi]
PST - ppublish
SO  - HEC Forum. 2010 Dec;22(4):267-74. doi: 10.1007/s10730-010-9134-5.


PMID- 20714198
OWN - NLM
STAT- MEDLINE
DCOM- 20101130
LR  - 20100817
IS  - 1423-0275 (Electronic)
IS  - 0301-1569 (Linking)
VI  - 72
IP  - 3
DP  - 2010
TI  - Clinical indication as an ethical appraisal: the example of imaging before middle
      ear surgery.
PG  - 138-43; discussion 144
LID - 10.1159/000272135 [doi]
AB  - PURPOSE OF THE STUDY: Asking whether imaging is indicated before middle ear
      surgery requires us to examine the question of indication more generally.
      PROCEDURES: Clinical indication integrates different levels, which are
      distinguished in this paper. As deciding whether or not an intervention is
      indicated requires different approaches on each of these levels, these approaches
      are also explored. RESULTS: Even when sufficient data are available to determine 
      whether an intervention brings some benefit, knowing whether or not this
      intervention is indicated still requires us to answer 3 additional questions: (1)
      Is the intervention sufficiently beneficial to be clinically relevant? (2) Is the
      intervention 'reasonable' in terms of its opportunity costs? (3) How are we to
      decide which interventions 'make the cut', and which do not? Although we may all 
      have an informed opinion on this topic, the question of the thresholds we ought
      to apply to very marginal benefits is one where the best answer can only be the
      one we have all agreed on. This requires a guideline integrating elements of
      procedural fairness, developed in conditions of protection from the risks of
      conflicts of interests. CONCLUSION: Although some of these questions integrate
      considerations of costs, not all do. However, all integrate value judgements,
      making clinical indication in part a question of ethical appraisal.
CI  - Copyright 2010 S. Karger AG, Basel.
FAU - Hurst, Samia A
AU  - Hurst SA
AD  - Institute for Biomedical Ethics, Geneva University Medical School, Geneva,
      Switzerland. samia.hurst@unige.ch
LA  - eng
PT  - Journal Article
DEP - 20100813
PL  - Switzerland
TA  - ORL J Otorhinolaryngol Relat Spec
JT  - ORL; journal for oto-rhino-laryngology and its related specialties
JID - 0334721
SB  - IM
MH  - Cost-Benefit Analysis
MH  - Decision Making/ethics
MH  - Ear Diseases/*diagnosis/economics/*surgery
MH  - Ear, Middle/*surgery
MH  - Humans
MH  - Otologic Surgical Procedures/economics/*ethics
MH  - Preoperative Care/economics/*ethics
MH  - Professional Practice/economics/ethics
EDAT- 2010/08/18 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/18 06:00
PHST- 2010/08/18 06:00 [entrez]
PHST- 2010/08/18 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 000272135 [pii]
AID - 10.1159/000272135 [doi]
PST - ppublish
SO  - ORL J Otorhinolaryngol Relat Spec. 2010;72(3):138-43; discussion 144. doi:
      10.1159/000272135. Epub 2010 Aug 13.


PMID- 20714113
OWN - NLM
STAT- MEDLINE
DCOM- 20110419
LR  - 20160519
IS  - 1663-2826 (Electronic)
IS  - 1663-2818 (Linking)
VI  - 74
IP  - 6
DP  - 2010
TI  - Ethical principles for the management of infants with disorders of sex
      development.
PG  - 412-8
LID - 10.1159/000316940 [doi]
AB  - The Fifth World Congress on Family Law and Children's Rights (Halifax, August
      2009) adopted a resolution endorsing a new set of ethical guidelines for the
      management of infants and children with disorders of sex development (DSD)
      [www.lawrights.asn.au/index.php?option = com_content&view = article&id =
      76&Itemid = 109]. The ethical principles developed by our group were the basis
      for the Halifax Resolution. In this paper, we outline these principles and
      explain their basis. The principles are intended as the ethical foundation for
      treatment decisions for DSD, especially decisions about type and timing of
      genital surgery for infants and young children. These principles were formulated 
      by an analytic review of clinician reasoning in particular cases, in relation to 
      established principles of bioethics, in a process consistent with the Rawlsian
      concept of reflective equilibrium as the method for building ethical theory. The 
      principles we propose are: (1) minimising physical risk to child; (2) minimising 
      psychosocial risk to child; (3) preserving potential for fertility; (4)
      preserving or promoting capacity to have satisfying sexual relations; (5) leaving
      options open for the future, and (6) respecting the parents' wishes and beliefs.
CI  - Copyright (c) 2010 S. Karger AG, Basel.
FAU - Gillam, Lynn H
AU  - Gillam LH
AD  - Children's Bioethics Centre, Royal Children's Hospital, Melbourne, Vic,
      Australia. l.gillam @ unimelb.edu.au
FAU - Hewitt, Jacqueline K
AU  - Hewitt JK
FAU - Warne, Garry L
AU  - Warne GL
LA  - eng
PT  - Journal Article
DEP - 20100812
PL  - Switzerland
TA  - Horm Res Paediatr
JT  - Hormone research in paediatrics
JID - 101525157
SB  - IM
CIN - Horm Res Paediatr. 2010;74(6):419-20. PMID: 21160198
MH  - Decision Making/*ethics
MH  - Disorders of Sex Development/surgery/*therapy
MH  - *Ethics, Medical
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Parents
MH  - Urologic Surgical Procedures/*ethics
EDAT- 2010/08/18 06:00
MHDA- 2011/04/20 06:00
CRDT- 2010/08/18 06:00
PHST- 2009/12/02 00:00 [received]
PHST- 2010/05/21 00:00 [accepted]
PHST- 2010/08/18 06:00 [entrez]
PHST- 2010/08/18 06:00 [pubmed]
PHST- 2011/04/20 06:00 [medline]
AID - 000316940 [pii]
AID - 10.1159/000316940 [doi]
PST - ppublish
SO  - Horm Res Paediatr. 2010;74(6):412-8. doi: 10.1159/000316940. Epub 2010 Aug 12.


PMID- 20713614
OWN - NLM
STAT- MEDLINE
DCOM- 20101029
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 257
IP  - 1
DP  - 2010 Oct
TI  - Cross-sectional study of tracheomegaly in children after fetal tracheal occlusion
      for severe congenital diaphragmatic hernia.
PG  - 226-32
LID - 10.1148/radiol.10092388 [doi]
AB  - PURPOSE: To measure tracheal dimensions in children with congenital diaphragmatic
      hernia (CDH) who had undergone fetoscopic endoluminal tracheal occlusion (FETO)
      or were treated expectantly during gestation. MATERIALS AND METHODS: The study
      was approved by the local ethics committee. Computed tomography was performed in 
      23 patients (14 boys and nine girls) aged 1 month to 6.5 years, and the
      anteroposterior diameter, width, area, and perimeter of the trachea were
      determined. Seven of the 23 patients had undergone FETO and 16 had been treated
      expectantly. The relative difference of each parameter between the two most
      proximal concentric sections of the trachea, just below the larynx, and the two
      sections on which the trachea was the largest was compared between both groups
      (Mann-Whitney U test). Regression statistics were applied to maximum and mean
      tracheal areas as a function of age. Each trachea was divided into quartiles, and
      mean areas normalized to 3 years of age were analyzed for each quartile as a
      function of its relative position on the trachea (Student t test). RESULTS:
      Tracheal width, area, and perimeter were significantly different between both
      groups. A linear relationship was observed between the maximum and mean tracheal 
      areas and age for both the FETO group (maximum tracheal area: R(2) = 0.83, P =
      .0045; mean tracheal area: R(2) = 0.92, P = .0005) and the non-FETO group
      (maximum tracheal area: R(2) = 0.66, P = .0001; mean trachea area: R(2) = 0.66, P
      = .0001). The maximum tracheal area in both groups tended to decrease toward the 
      age of 5 years. Significantly different mean tracheal areas per tracheal quartile
      (P < .05) were found for all quartiles except for the proximal one-fourth.
      CONCLUSION: The relative difference between proximal and largest tracheal width, 
      area, and perimeter was significantly larger in patients who underwent FETO than 
      in those treated expectantly, demonstrating tracheal dilatation in the former.
      Measurements of tracheal dimensions at different levels indicate a maximum
      dilatation in the lower half of the trachea, which tends to level off toward the 
      age of 5 years.
FAU - Breysem, Luc
AU  - Breysem L
AD  - Department of Radiology, University Hospitals Leuven, Herestraat 49, Leuven,
      Belgium. luc.breysem@uz.kuleuven.ac.be
FAU - Debeer, Anne
AU  - Debeer A
FAU - Claus, Filip
AU  - Claus F
FAU - Proesmans, Marijke
AU  - Proesmans M
FAU - De Keyzer, Frederik
AU  - De Keyzer F
FAU - Lewi, Paul
AU  - Lewi P
FAU - Allegaert, Karel
AU  - Allegaert K
FAU - Smet, Maria-Helena
AU  - Smet MH
FAU - Deprest, Jan
AU  - Deprest J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100816
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - *Balloon Occlusion
MH  - Child
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Female
MH  - Fetoscopy/*methods
MH  - Hernia, Diaphragmatic/diagnostic imaging/*surgery
MH  - *Hernias, Diaphragmatic, Congenital
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Regression Analysis
MH  - Statistics, Nonparametric
MH  - Tomography, X-Ray Computed
MH  - *Trachea
MH  - Treatment Outcome
EDAT- 2010/08/18 06:00
MHDA- 2010/10/30 06:00
CRDT- 2010/08/18 06:00
PHST- 2010/08/18 06:00 [entrez]
PHST- 2010/08/18 06:00 [pubmed]
PHST- 2010/10/30 06:00 [medline]
AID - radiol.10092388 [pii]
AID - 10.1148/radiol.10092388 [doi]
PST - ppublish
SO  - Radiology. 2010 Oct;257(1):226-32. doi: 10.1148/radiol.10092388. Epub 2010 Aug
      16.


PMID- 20713610
OWN - NLM
STAT- MEDLINE
DCOM- 20101029
LR  - 20191210
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 257
IP  - 1
DP  - 2010 Oct
TI  - Gastroesophageal junction: structure and function as assessed by using MR
      imaging.
PG  - 115-24
LID - 10.1148/radiol.10092340 [doi]
AB  - PURPOSE: To develop and validate magnetic resonance (MR) imaging protocols for
      quantitative assessment of the structural and functional properties of the
      gastroesophageal junction (GEJ) and to compare MR imaging detection of reflux
      events against concurrent manometry as a reference method. MATERIALS AND METHODS:
      The local ethics committee approved this study, and written informed consent was 
      obtained. Twelve healthy volunteers were examined. Three-dimensional models of
      the GEJ and proximal portion of the stomach were reconstructed from
      high-spatial-resolution anatomic MR images to assess the insertion angle of the
      esophagus into the stomach and proximal stomach distention before and after
      ingestion of a large test meal. A linear mixed-effects model was used to detect
      differences in the insertion angle and proximal stomach distention with respect
      to the respiratory cycle and gastric filling. Additionally, dynamic MR imaging at
      high temporal resolution was used to detect reflux events. RESULTS: The
      esophageal insertion angle, given in units of plane angle (radians), was more
      acute in expiration than in inspiration (0.57 vs 0.73 radian, P = .004) but was
      not affected by feeding. Progressive distention of the proximal stomach was
      observed from baseline compared with the postprandial period (0.95 vs 0.65
      radian(-1), P < .05). Eighteen reflux events detected by using MR imaging were
      also detected by using manometry. CONCLUSION: MR imaging methods were developed
      and validated for the assessment of GEJ structure and function (a) to describe
      the effects of respiration and feeding on the reflux barrier and (b) to detect
      reflux events in real time. Anatomic and dynamic MR imaging may be useful
      techniques in the assessment of GEJ physiology and reflux.
FAU - Curcic, Jelena
AU  - Curcic J
AD  - Institute for Biomedical Engineering, University of Zurich and Swiss Federal
      Institute of Technology, Zurich, Switzerland.
FAU - Fox, Mark
AU  - Fox M
FAU - Kaufman, Elad
AU  - Kaufman E
FAU - Forras-Kaufman, Zsofia
AU  - Forras-Kaufman Z
FAU - Hebbard, Geoffrey S
AU  - Hebbard GS
FAU - Roy, Shammodip
AU  - Roy S
FAU - Pal, Anupam
AU  - Pal A
FAU - Schwizer, Werner
AU  - Schwizer W
FAU - Fried, Michael
AU  - Fried M
FAU - Treier, Reto
AU  - Treier R
FAU - Boesiger, Peter
AU  - Boesiger P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20100816
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adult
MH  - Esophagogastric Junction/*anatomy & histology/*physiology
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Imaging, Three-Dimensional
MH  - Linear Models
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Manometry
MH  - Reference Values
EDAT- 2010/08/18 06:00
MHDA- 2010/10/30 06:00
CRDT- 2010/08/18 06:00
PHST- 2010/08/18 06:00 [entrez]
PHST- 2010/08/18 06:00 [pubmed]
PHST- 2010/10/30 06:00 [medline]
AID - radiol.10092340 [pii]
AID - 10.1148/radiol.10092340 [doi]
PST - ppublish
SO  - Radiology. 2010 Oct;257(1):115-24. doi: 10.1148/radiol.10092340. Epub 2010 Aug
      16.


PMID- 20713608
OWN - NLM
STAT- MEDLINE
DCOM- 20101029
LR  - 20151119
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 257
IP  - 1
DP  - 2010 Oct
TI  - 23Na MR imaging at 7 T after knee matrix-associated autologous chondrocyte
      transplantation preliminary results.
PG  - 175-84
LID - 10.1148/radiol.10100279 [doi]
AB  - PURPOSE: To evaluate the feasibility of sodium 7-T magnetic resonance (MR)
      imaging in repaired tissue and native cartilage of patients after
      matrix-associated autologous chondrocyte transplantation (MACT) and compare
      results with delayed gadolinium-enhanced MR imaging of cartilage (dGEMRIC) at 3
      T. MATERIALS AND METHODS: Ethical approval was provided by the local ethics
      committee; written informed consent was obtained from all patients. Six women and
      six men (mean age, 32.8 year +/- 8.2 [standard deviation] and 32.3 years +/-
      12.7, respectively) were included. Mean time between MACT and MR was 56 months
      +/- 28. A variable three-dimensional (3D) gradient-echo (GRE) dual-flip-angle
      technique was used for T1 mapping before and after contrast agent administration 
      at 3 T. All patients were also examined at 7 T (mean delay, 70.5 days +/- 80.1). 
      A sodium 23-only transmit-receive knee coil was used with the 3D GRE sequence. A 
      statistical analysis of variance and Pearson correlation were applied. RESULTS:
      Mean signal-to-noise ratio (SNR) was 24 in native cartilage and was 16 in
      transplants (P < .001). Mean sodium signal intensities normalized with the
      reference sample were 174 +/- 53 and 267 +/- 42 for repaired tissue in the
      cartilage transplant and healthy cartilage, respectively (P < .001). Mean
      postcontrast T1 values were 510 msec +/- 195 and 756 msec +/- 188 for repaired
      tissue and healthy cartilage, respectively (P = .005). Mean score of MR
      observation of cartilage repair tissue was 75 +/- 14. Association between
      postcontrast T1 and normalized sodium signal values showed a high Pearson
      correlation coefficient (R) of 0.706 (P = .001). A high correlation of R = 0.836 
      (P = .001) was found between ratios of normalized sodium values and ratios of T1 
      postcontrast values. CONCLUSION: With the modified 3D GRE sequence at 7 T, a
      sufficiently high SNR in sodium images was achieved, allowing for differentiation
      of repaired tissue from native cartilage after MACT. A strong correlation was
      found between sodium imaging and dGEMRIC in patients after MACT.
FAU - Trattnig, Siegfried
AU  - Trattnig S
AD  - Department of Radiology, MR Centre-High Field MR, Medical University of Vienna,
      Lazarettgasse 14, Vienna, Austria. siegfried.trattnig@meduniwien.ac.at
FAU - Welsch, Goetz H
AU  - Welsch GH
FAU - Juras, Vladimir
AU  - Juras V
FAU - Szomolanyi, Pavol
AU  - Szomolanyi P
FAU - Mayerhoefer, Marius E
AU  - Mayerhoefer ME
FAU - Stelzeneder, David
AU  - Stelzeneder D
FAU - Mamisch, Tallal C
AU  - Mamisch TC
FAU - Bieri, Oliver
AU  - Bieri O
FAU - Scheffler, Klaus
AU  - Scheffler K
FAU - Zbyn, Stefan
AU  - Zbyn S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100816
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - 0 (Sodium Isotopes)
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Cartilage, Articular/*pathology/*surgery
MH  - Chondrocytes/*transplantation
MH  - Contrast Media
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Imaging, Three-Dimensional
MH  - Knee Joint/*pathology/*surgery
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Sodium Isotopes
MH  - Transplantation, Autologous
MH  - Treatment Outcome
EDAT- 2010/08/18 06:00
MHDA- 2010/10/30 06:00
CRDT- 2010/08/18 06:00
PHST- 2010/08/18 06:00 [entrez]
PHST- 2010/08/18 06:00 [pubmed]
PHST- 2010/10/30 06:00 [medline]
AID - radiol.10100279 [pii]
AID - 10.1148/radiol.10100279 [doi]
PST - ppublish
SO  - Radiology. 2010 Oct;257(1):175-84. doi: 10.1148/radiol.10100279. Epub 2010 Aug
      16.


PMID- 20713535
OWN - NLM
STAT- MEDLINE
DCOM- 20110225
LR  - 20101022
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 11
DP  - 2010 Nov
TI  - The use of vignettes within a Delphi exercise: a useful approach in empirical
      ethics?
PG  - 656-60
LID - 10.1136/jme.2010.036616 [doi]
AB  - There has been an increase in recent years in the use of empirical methods in
      healthcare ethics. Appeals to empirical data cannot answer moral questions, but
      insights into the knowledge, attitudes, experience, preferences and practice of
      interested parties can play an important part in the development of healthcare
      ethics. In particular, while we may establish a general ethical principle to
      provide explanatory and normative guidance for healthcare professionals, the
      interpretation and application of such general principles to actual practice
      still requires interpretation and judgement. And many situations in healthcare
      practice are complex and may involve a variety of principles, each of which may
      conflict with the others. Simple surveys or interview studies may not be
      sufficient if we wish to develop a nuanced approach to ethical practice that can 
      be set out in guidelines, codes or directives. We do not resolve moral questions 
      by plebiscite. In this paper, the authors argue for the use of consensus methods 
      to develop shared understanding of ethical practice, and they argue further for
      the combination of the Delphi method with the use of vignettes to illustrate the 
      kind of situations that may occur in practice. They develop their argument in
      part by reference to their experience of using this approach in their recent
      research.
FAU - Wainwright, Paul
AU  - Wainwright P
AD  - Kingston University and St George's University of London, Faculty of Health and
      Social Care Sciences, Kingston, UK.
FAU - Gallagher, Ann
AU  - Gallagher A
FAU - Tompsett, Hilary
AU  - Tompsett H
FAU - Atkins, Christine
AU  - Atkins C
LA  - eng
GR  - Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100816
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Attitude of Health Personnel
MH  - *Delphi Technique
MH  - *Empirical Research
MH  - *Ethics, Medical
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
EDAT- 2010/08/18 06:00
MHDA- 2011/02/26 06:00
CRDT- 2010/08/18 06:00
PHST- 2010/08/18 06:00 [entrez]
PHST- 2010/08/18 06:00 [pubmed]
PHST- 2011/02/26 06:00 [medline]
AID - jme.2010.036616 [pii]
AID - 10.1136/jme.2010.036616 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Nov;36(11):656-60. doi: 10.1136/jme.2010.036616. Epub 2010 Aug
      16.


PMID- 20713533
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20151119
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 10
DP  - 2010 Oct
TI  - Morality and moral conflicts in hospice care: results of a qualitative interview 
      study.
PG  - 588-92
LID - 10.1136/jme.2009.034462 [doi]
AB  - Hospices consider themselves places that practise a holistic form of terminal
      care, encompassing physical and psychological symptoms, and also the social and
      spiritual support for a dying patient. So far, the underlying ethical principles 
      have been treated predominantly in terms of a normative theoretical discussion.
      The interview study discussed in this paper is a qualitative investigation into
      general and hospice-related conceptions of morality among full-time and voluntary
      workers in German inpatient hospices. It examines moral conflicts and efforts
      leading to their solution. The main ideas identified include moral neutrality
      towards the patients and their requests, the capability of acceptance, the idea
      of self-restraint with respect to the dying patient and the principle of respect 
      for the natural course of dying. Essential triggers for moral conflicts were the 
      inadequate education of patients, problems of acceptance in view of incurable
      disease, and disagreements between members of patients' families. The
      interviewees expressed their scepticism towards formal institutions of ethical
      counselling. The study has shown a type of virtue ethics that forms an integral
      part of the overall concept of hospice care, which cannot be treated separately
      from a holistic idea of care at the end of life.
FAU - Salloch, Sabine
AU  - Salloch S
AD  - Institut fuer Medizinische Ethik und Geschichte der Medizin, Ruhr-Universitaet
      Bochum, Markstrasse 258a, D-44799 Bochum, Germany. Sabine.Salloch-s52@Rub.de
FAU - Breitsameter, Christof
AU  - Breitsameter C
LA  - eng
PT  - Journal Article
DEP - 20100816
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Attitude of Health Personnel
MH  - *Conflict of Interest
MH  - Female
MH  - Germany
MH  - Hospice Care/*ethics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Morals
MH  - Nursing Staff/*ethics/psychology
MH  - Qualitative Research
MH  - Surveys and Questionnaires
EDAT- 2010/08/18 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/08/18 06:00
PHST- 2010/08/18 06:00 [entrez]
PHST- 2010/08/18 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - jme.2009.034462 [pii]
AID - 10.1136/jme.2009.034462 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Oct;36(10):588-92. doi: 10.1136/jme.2009.034462. Epub 2010 Aug
      16.


PMID- 20713274
OWN - NLM
STAT- MEDLINE
DCOM- 20110104
LR  - 20220310
IS  - 1532-6500 (Electronic)
IS  - 1058-2746 (Linking)
VI  - 19
IP  - 6
DP  - 2010 Sep
TI  - Locked intramedullary fixation vs plating for displaced and shortened mid-shaft
      clavicle fractures: a randomized clinical trial.
PG  - 783-9
LID - 10.1016/j.jse.2010.05.002 [doi]
AB  - BACKGROUND: Recent literature supports surgical intervention for shortened,
      displaced, mid-shaft clavicle fractures. We present the results of a randomized
      clinical trial comparing locked intramedullary fixation and plate fixation for
      short, displaced, mid-shaft clavicle fractures. MATERIALS AND METHODS: Local
      ethical approval was obtained and power analysis and sample size calculations
      were performed prior to commencement. Patients randomized to 2 groups to be
      treated with either locked intramedullary fixation or plating. Patients regularly
      followed up to clinical and radiographic union. The primary outcome measure was
      the Constant score, secondary outcome measures included the Oxford shoulder
      score, union rate, and complication rates. RESULTS: Seventeen patients were
      randomized to locked intramedullary fixation and 15 randomized to plating. Mean
      age was 29.3 years. Mean follow-up was 12.4 months. There was no significant
      difference in either Constant scores (P = .365) or Oxford scores (P = .773).
      There was 100% union in both groups. In the intramedullary group, 1 case of soft 
      tissue irritation settled after the pin removal; 1 pin backed out and was
      revised. Three superficial wound infections resulted in plate removal and 8
      plates (53%) were removed. DISCUSSION: Intramedullary fixation has the
      theoretical advantage of preserving the periosteal blood supply, but carries the 
      morbidity of pin removal. Clavicle plates are not routinely removed but require
      greater exposure and may compromise periosteal blood supply. CONCLUSION: Both
      locked intramedullary fixation and plating produce good functional results;
      however, metalwork may need to be removed as a second procedure.
CI  - (c) 2010 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by
      Mosby, Inc. All rights reserved.
FAU - Ferran, Nicholas A
AU  - Ferran NA
AD  - Department of Trauma and Orthopaedic Surgery, Lincoln County Hospital, Lincoln,
      UK. nferran@uku.co.uk
FAU - Hodgson, Paul
AU  - Hodgson P
FAU - Vannet, Nicola
AU  - Vannet N
FAU - Williams, Rhys
AU  - Williams R
FAU - Evans, Richard O
AU  - Evans RO
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - J Shoulder Elbow Surg
JT  - Journal of shoulder and elbow surgery
JID - 9206499
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Bone Nails
MH  - *Bone Plates
MH  - Clavicle/diagnostic imaging/*injuries/surgery
MH  - Female
MH  - Follow-Up Studies
MH  - Fracture Fixation, Intramedullary/*instrumentation
MH  - Fractures, Bone/diagnostic imaging/*surgery
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Radiography
MH  - Retrospective Studies
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2010/08/18 06:00
MHDA- 2011/01/05 06:00
CRDT- 2010/08/18 06:00
PHST- 2009/12/11 00:00 [received]
PHST- 2010/05/02 00:00 [revised]
PHST- 2010/05/08 00:00 [accepted]
PHST- 2010/08/18 06:00 [entrez]
PHST- 2010/08/18 06:00 [pubmed]
PHST- 2011/01/05 06:00 [medline]
AID - S1058-2746(10)00205-3 [pii]
AID - 10.1016/j.jse.2010.05.002 [doi]
PST - ppublish
SO  - J Shoulder Elbow Surg. 2010 Sep;19(6):783-9. doi: 10.1016/j.jse.2010.05.002.


PMID- 20712838
OWN - NLM
STAT- MEDLINE
DCOM- 20110120
LR  - 20151119
IS  - 1651-2227 (Electronic)
IS  - 0803-5253 (Linking)
VI  - 99
IP  - 12
DP  - 2010 Dec
TI  - Current empirical research in neonatal bioethics.
PG  - 1773-81
LID - 10.1111/j.1651-2227.2010.01971.x [doi]
AB  - UNLABELLED: Ethical dilemmas in neonatology can be analysed using both the
      theoretical tools of analytic philosophy and the empirical tools of clinical
      epidemiology and health services research. Both yield important insights into
      ways to think about the ethical issues that arise in clinical neonatology. In
      this paper, we review recent empirical research in neonatal bioethics. Studies
      published in the last 5 years shed light on issues that arise in prenatal
      consultation, prognostication, outcomes, quality-of-life and cost-effectiveness
      in neonatal intensive care. These studies show ways in which doctors vary in
      their decisions from country to country, hospital to hospital and for babies and 
      children with different conditions but similar prognoses. Empirical research in
      bioethics can answer questions about what doctors and parents think and do. It
      does not answer questions about what they ought to do. CONCLUSION: Good ethics
      starts with good facts, even if good facts are not sufficient to get us to good
      ethics.
CI  - (c) 2010 The Author(s)/Acta Paediatrica (c) 2010 Foundation Acta Paediatrica.
FAU - Swinton, Cameron H
AU  - Swinton CH
AD  - The University of Chicago, Chicago, IL, USA. jlantos@cmh.edu
FAU - Lantos, John D
AU  - Lantos JD
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100831
PL  - Norway
TA  - Acta Paediatr
JT  - Acta paediatrica (Oslo, Norway : 1992)
JID - 9205968
SB  - IM
MH  - *Bioethical Issues
MH  - Decision Making
MH  - *Empirical Research
MH  - Humans
MH  - Infant, Newborn
MH  - Neonatology/*ethics
MH  - Practice Patterns, Physicians'
EDAT- 2010/08/18 06:00
MHDA- 2011/01/21 06:00
CRDT- 2010/08/18 06:00
PHST- 2010/08/18 06:00 [entrez]
PHST- 2010/08/18 06:00 [pubmed]
PHST- 2011/01/21 06:00 [medline]
AID - APA1971 [pii]
AID - 10.1111/j.1651-2227.2010.01971.x [doi]
PST - ppublish
SO  - Acta Paediatr. 2010 Dec;99(12):1773-81. doi: 10.1111/j.1651-2227.2010.01971.x.
      Epub 2010 Aug 31.


PMID- 20712791
OWN - NLM
STAT- MEDLINE
DCOM- 20100917
LR  - 20100817
IS  - 1749-6632 (Electronic)
IS  - 0077-8923 (Linking)
VI  - 1202
DP  - 2010 Aug
TI  - Complexity of alpha thalassemia: growing health problem with new approaches to
      screening, diagnosis, and therapy.
PG  - 180-7
LID - 10.1111/j.1749-6632.2010.05572.x [doi]
AB  - Alpha thalassemia, the most common genetic disorder of hemoglobin synthesis,
      affects up to 5% of the world's population. It represents a group of conditions
      with reduced or absent synthesis of one to all four of alpha globin genes.
      Deletional or nondeletional mutations occur on chromosome 16. Its severity ranges
      from asymptomatic to fatal in utero. Hemoglobin H disease, a mutation of three
      alpha globin genes, is more severe than previously recognized. Anemia,
      hypersplenism, hemosiderosis, growth failure, and osteoporosis are commonly noted
      as the patient ages. Alpha thalassemia major, a usually fatal in utero disease,
      is now recognized to have a complex molecular and phenotypic expression with
      increasing births being reported. Surviving newborns without intrauterine
      transfusion often have congenital anomalies and neurocognitive injury. Serious
      maternal complications often accompany pregnancy. Doppler ultrasonography with
      intrauterine transfusion ameliorates these complications. The high incidence in
      many populations mandates population screening and prenatal diagnosis of at-risk 
      couples. Universal newborn screening has been adopted in several regions with DNA
      confirmatory testing. These advances have resulted in ethical dilemmas for the
      family and the provider.
FAU - Vichinsky, Elliott
AU  - Vichinsky E
AD  - Children's Hospital & Research Center Oakland, Oakland, Califorina, USA.
      evichinsky@mail.cho.org
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (alpha-Globins)
SB  - IM
MH  - Blood Transfusion
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Mutation
MH  - Neonatal Screening
MH  - Phenotype
MH  - Pregnancy
MH  - Pregnancy Complications
MH  - Prenatal Diagnosis
MH  - alpha-Globins/*genetics
MH  - alpha-Thalassemia/*diagnosis/*epidemiology/genetics/*therapy
EDAT- 2010/08/18 06:00
MHDA- 2010/09/21 06:00
CRDT- 2010/08/18 06:00
PHST- 2010/08/18 06:00 [entrez]
PHST- 2010/08/18 06:00 [pubmed]
PHST- 2010/09/21 06:00 [medline]
AID - NYAS5572 [pii]
AID - 10.1111/j.1749-6632.2010.05572.x [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2010 Aug;1202:180-7. doi: 10.1111/j.1749-6632.2010.05572.x.


PMID- 20712727
OWN - NLM
STAT- MEDLINE
DCOM- 20101208
LR  - 20211020
IS  - 1751-7893 (Electronic)
IS  - 1751-7885 (Linking)
VI  - 4
IP  - 3
DP  - 2010 Aug
TI  - Treatment history in the psychosis prodrome: characteristics of the North
      American Prodrome Longitudinal Study Cohort.
PG  - 220-6
LID - 10.1111/j.1751-7893.2010.00183.x [doi]
AB  - AIM: Early identification and better characterization of the prodromal phase of
      psychotic illness can lead to targeted treatment and, perhaps, prevention of many
      of the devastating effects of a first psychotic episode. The primary aim of this 
      manuscript is to describe the treatment histories of a large cohort of
      individuals who entered into one of seven prodromal research programs in a North 
      American Prodrome Longitudinal Study consortium. METHODS: Treatment histories
      from 372 clinical high-risk subjects are described along with demographic,
      symptom, diagnostic and functional variables that may have contributed to
      treatment decisions for this group of individuals. RESULTS: Of all subjects
      included, 82.1% had received psychosocial and/or pharmacologic treatment prior to
      entry. Psychosocial interventions were more common in the attenuated psychotic
      syndrome prodromal sample, especially those with more negative, disorganized or
      general symptoms and more impaired functioning. Psychotropic medication had been 
      administered to individuals with a history of Axis I disorders. CONCLUSIONS:
      Given the many potential clinical presentations, treatments and ethical issues
      connected with the psychosis-risk syndrome, it is not surprising that clinicians 
      administered a broad range of interventions to study participants prior to their 
      entry into the various research programs. Those individuals with milder and
      non-specific symptoms were more likely to have received psychosocial treatments, 
      whereas those with more severe symptoms received pharmacologic intervention.
      Clinical treatment research is needed that addresses the complexities of these
      psychosis-risk states and helps to specify appropriate treatment at different
      stages of the psychosis prodrome.
FAU - Cadenhead, Kristin S
AU  - Cadenhead KS
AD  - Department of Psychiatry and Biobehavioral Sciences, UCSD, San Diego, California 
      92093-0810, USA. kcadenhead@ucsd.edu
FAU - Addington, Jean
AU  - Addington J
FAU - Cannon, Tyrone
AU  - Cannon T
FAU - Cornblatt, Barbara
AU  - Cornblatt B
FAU - McGlashan, Thomas
AU  - McGlashan T
FAU - Perkins, Diana
AU  - Perkins D
FAU - Seidman, Larry
AU  - Seidman L
FAU - Tsuang, Ming
AU  - Tsuang M
FAU - Walker, Elaine
AU  - Walker E
FAU - Woods, Scott
AU  - Woods S
FAU - Heinssen, Robert
AU  - Heinssen R
LA  - eng
GR  - K24 MH076191-02/MH/NIMH NIH HHS/United States
GR  - R01 MH065079/MH/NIMH NIH HHS/United States
GR  - R01 MH061523/MH/NIMH NIH HHS/United States
GR  - U01 MH081944-03/MH/NIMH NIH HHS/United States
GR  - U01 MH081944-01A1/MH/NIMH NIH HHS/United States
GR  - R01 MH060720-06A1/MH/NIMH NIH HHS/United States
GR  - P50 MH080272/MH/NIMH NIH HHS/United States
GR  - R01 MH060720-10/MH/NIMH NIH HHS/United States
GR  - U01 MH081944-02/MH/NIMH NIH HHS/United States
GR  - P50 MH064065/MH/NIMH NIH HHS/United States
GR  - R01 MH060720-04/MH/NIMH NIH HHS/United States
GR  - R21 MH075027/MH/NIMH NIH HHS/United States
GR  - R01 MH060720-03/MH/NIMH NIH HHS/United States
GR  - R01 MH060720-07/MH/NIMH NIH HHS/United States
GR  - R01 MH060720-02/MH/NIMH NIH HHS/United States
GR  - R01 MH060720-05/MH/NIMH NIH HHS/United States
GR  - K24 MH076191-03/MH/NIMH NIH HHS/United States
GR  - R01 MH060720-01A1/MH/NIMH NIH HHS/United States
GR  - R01 MH060720/MH/NIMH NIH HHS/United States
GR  - K24 MH076191-04/MH/NIMH NIH HHS/United States
GR  - U01 MH081944-04/MH/NIMH NIH HHS/United States
GR  - K05 MH001654/MH/NIMH NIH HHS/United States
GR  - K23 MH001905/MH/NIMH NIH HHS/United States
GR  - R01 MH060720-09/MH/NIMH NIH HHS/United States
GR  - U01 MH066069/MH/NIMH NIH HHS/United States
GR  - K24 MH076191-05/MH/NIMH NIH HHS/United States
GR  - R01 MH062066/MH/NIMH NIH HHS/United States
GR  - R01 MH065562/MH/NIMH NIH HHS/United States
GR  - U01 MH066160/MH/NIMH NIH HHS/United States
GR  - K24 MH076191/MH/NIMH NIH HHS/United States
GR  - R01 MH060720-08/MH/NIMH NIH HHS/United States
GR  - U01 MH066134/MH/NIMH NIH HHS/United States
GR  - K24 MH076191-01A1/MH/NIMH NIH HHS/United States
GR  - U01 MH082004/MH/NIMH NIH HHS/United States
GR  - U01 MH081944/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PL  - Australia
TA  - Early Interv Psychiatry
JT  - Early intervention in psychiatry
JID - 101320027
RN  - 0 (Antipsychotic Agents)
SB  - IM
CIN - Early Interv Psychiatry. 2010 Aug;4(3):197-9. PMID: 20712723
MH  - Adolescent
MH  - Antipsychotic Agents/*administration & dosage
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - North America
MH  - Practice Patterns, Physicians'/trends
MH  - Psychotherapy/*methods
MH  - Psychotic Disorders/diagnosis/*drug therapy/*therapy
MH  - Young Adult
PMC - PMC3065350
MID - NIHMS276977
EDAT- 2010/08/18 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/18 06:00
PHST- 2010/08/18 06:00 [entrez]
PHST- 2010/08/18 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - EIP183 [pii]
AID - 10.1111/j.1751-7893.2010.00183.x [doi]
PST - ppublish
SO  - Early Interv Psychiatry. 2010 Aug;4(3):220-6. doi:
      10.1111/j.1751-7893.2010.00183.x.


PMID- 20712663
OWN - NLM
STAT- MEDLINE
DCOM- 20110217
LR  - 20100817
IS  - 1440-1800 (Electronic)
IS  - 1320-7881 (Linking)
VI  - 17
IP  - 3
DP  - 2010 Sep
TI  - Dignity in health-care: a critical exploration using feminism and theories of
      recognition.
PG  - 248-56
LID - 10.1111/j.1440-1800.2010.00494.x [doi]
AB  - Growing concerns over undignified health-care has meant the concept of dignity is
      currently much discussed in the British National Health Service. This has led to 
      a number of policies attempting to reinstate dignity as a core ethical value
      governing nursing practice and health-care provision. Yet these initiatives
      continue to draw upon a concept of dignity which remains reliant upon a
      depoliticised, ahistorical and decontexualised subject. In this paper, we argue
      the need to revise the dignity debate through the lens of feminism and theories
      of recognition. Postmodern feminist theories provide major challenges to what
      remain dominant liberal approaches as they pay attention to the contingent,
      reflexive, and affective aspects of care work. Theories of recognition provide a 
      further critical resource for understanding how moral obligations and
      responsibilities towards others and our public and private responses to
      difference arise. This re-situates dignity as a highly contested and politicised 
      concept involving complex moral deliberations and diverse political claims of
      recognition. The dignity debate is thus moved beyond simplistic rational
      injunctions to care, or to care more, and towards critical discussions of complex
      politicised, moral practices infused with power that involve the recognition of
      difference in health-care.
FAU - Aranda, Kay
AU  - Aranda K
AD  - University of Brighton, Falmer, East Sussex, UK. k.f.aranda@brighton.ac.uk
FAU - Jones, Andrea
AU  - Jones A
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Nurs Inq
JT  - Nursing inquiry
JID - 9505881
MH  - Advanced Practice Nursing/*methods
MH  - *Feminism
MH  - Humans
MH  - Models, Nursing
MH  - Models, Psychological
MH  - Nurse's Role/psychology
MH  - Patient Care Team
MH  - *Personhood
MH  - *Prejudice
MH  - *Psychological Theory
MH  - *Social Support
EDAT- 2010/08/18 06:00
MHDA- 2011/02/18 06:00
CRDT- 2010/08/18 06:00
PHST- 2010/08/18 06:00 [entrez]
PHST- 2010/08/18 06:00 [pubmed]
PHST- 2011/02/18 06:00 [medline]
AID - NIN494 [pii]
AID - 10.1111/j.1440-1800.2010.00494.x [doi]
PST - ppublish
SO  - Nurs Inq. 2010 Sep;17(3):248-56. doi: 10.1111/j.1440-1800.2010.00494.x.


PMID- 20712547
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20201219
IS  - 0025-729X (Print)
IS  - 0025-729X (Linking)
VI  - 193
IP  - 4
DP  - 2010 Aug 16
TI  - Legal and ethical aspects of refusing medical treatment after a suicide attempt: 
      the Wooltorton case in the Australian context.
PG  - 239-42
AB  - When a patient presents to hospital after a suicide attempt and appears to refuse
      treatment, clinicians should first assess if he or she should be treated under
      mental health legislation, regardless of competence to refuse treatment. When it 
      is not possible or is inappropriate to treat under mental health legislation, the
      person's competence to refuse treatment should be assessed. If the patient is
      definitely competent, his or her decision to refuse treatment should probably be 
      honoured. If an incompetent patient carries a document refusing treatment,
      clinicians must determine the validity of that document as an advance care
      directive - including whether or not the patient was competent at the time it was
      written. The law around the right to refuse treatment after a suicide attempt
      remains unclear and, if uncertain of what to do, clinicians should provide
      urgently required life-saving treatment and simultaneously seek an urgent court
      order to clarify how they should proceed. In all but extraordinary circumstances,
      a patient who refuses treatment after a suicide attempt can and should be given
      life-saving treatment, under either mental health legislation or the common law
      concept of necessity.
FAU - Ryan, Christopher J
AU  - Ryan CJ
AD  - Centre for Values, Ethics and the Law in Medicine, University of Sydney, Sydney, 
      NSW, Australia. christopher.ryan@sydney.edu.au
FAU - Callaghan, Sascha
AU  - Callaghan S
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Med J Aust
JT  - The Medical journal of Australia
JID - 0400714
SB  - IM
MH  - Advance Directives/ethics/*legislation & jurisprudence
MH  - Australia
MH  - Humans
MH  - Mental Competency/*legislation & jurisprudence
MH  - Right to Die/ethics/*legislation & jurisprudence
MH  - Suicide, Attempted/legislation & jurisprudence/*prevention & control
MH  - Withholding Treatment/*ethics/*legislation & jurisprudence
EDAT- 2010/08/18 06:00
MHDA- 2010/09/16 06:00
CRDT- 2010/08/18 06:00
PHST- 2010/01/16 00:00 [received]
PHST- 2010/06/06 00:00 [accepted]
PHST- 2010/08/18 06:00 [entrez]
PHST- 2010/08/18 06:00 [pubmed]
PHST- 2010/09/16 06:00 [medline]
AID - rya10032_fm [pii]
AID - 10.5694/j.1326-5377.2010.tb03880.x [doi]
PST - ppublish
SO  - Med J Aust. 2010 Aug 16;193(4):239-42. doi: 10.5694/j.1326-5377.2010.tb03880.x.


PMID- 20712295
OWN - NLM
STAT- MEDLINE
DCOM- 20100928
LR  - 20100817
IS  - 0882-1577 (Print)
IS  - 0882-1577 (Linking)
VI  - 91
IP  - 4
DP  - 2010 Jul-Aug
TI  - The ethical and religious directives as particular law.
PG  - 80-1
FAU - O'Rourke, Kevin D
AU  - O'Rourke KD
AD  - Neiswanger Insitute for Bioethics and Public Policy, Stritch School of Medicine, 
      Loyola University, Chicago, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Health Prog
JT  - Health progress (Saint Louis, Mo.)
JID - 8500263
MH  - *Catholicism
MH  - *Constitution and Bylaws
MH  - *Ethics
MH  - United States
EDAT- 2010/08/18 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/08/18 06:00
PHST- 2010/08/18 06:00 [entrez]
PHST- 2010/08/18 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
PST - ppublish
SO  - Health Prog. 2010 Jul-Aug;91(4):80-1.


PMID- 20712289
OWN - NLM
STAT- MEDLINE
DCOM- 20100928
LR  - 20100817
IS  - 0882-1577 (Print)
IS  - 0882-1577 (Linking)
VI  - 91
IP  - 4
DP  - 2010 Jul-Aug
TI  - Lamentation: the ethics/gospel divide.
PG  - 55-9
FAU - Kenny, Nuala P
AU  - Kenny NP
AD  - Dalhousie University, Halifax, Nova Scotia.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Health Prog
JT  - Health progress (Saint Louis, Mo.)
JID - 8500263
MH  - *Ethics, Medical
MH  - *Religion and Medicine
EDAT- 2010/08/18 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/08/18 06:00
PHST- 2010/08/18 06:00 [entrez]
PHST- 2010/08/18 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
PST - ppublish
SO  - Health Prog. 2010 Jul-Aug;91(4):55-9.


PMID- 20712288
OWN - NLM
STAT- MEDLINE
DCOM- 20100928
LR  - 20100817
IS  - 0882-1577 (Print)
IS  - 0882-1577 (Linking)
VI  - 91
IP  - 4
DP  - 2010 Jul-Aug
TI  - Teaching in Africa: medical ethics Zimbabwe-style.
PG  - 50-4
FAU - Nairn, Thomas
AU  - Nairn T
AD  - Catholic Health Association, St. Louis, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Health Prog
JT  - Health progress (Saint Louis, Mo.)
JID - 8500263
MH  - Education, Medical
MH  - *Ethics, Medical
MH  - Humans
MH  - Teaching/*organization & administration
MH  - Zimbabwe
EDAT- 2010/08/18 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/08/18 06:00
PHST- 2010/08/18 06:00 [entrez]
PHST- 2010/08/18 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
PST - ppublish
SO  - Health Prog. 2010 Jul-Aug;91(4):50-4.


PMID- 20712234
OWN - NLM
STAT- MEDLINE
DCOM- 20100903
LR  - 20100817
IS  - 1351-5578 (Print)
IS  - 1351-5578 (Linking)
VI  - 17
IP  - 4
DP  - 2010
TI  - Participant overexposure and the role of researcher judgement.
PG  - 49-59
AB  - Ethical conduct discussion often focuses on decisions made before and during the 
      research process. In contrast, this paper offers a reflective and personal
      post-factum critique of two distinct elements of ethical practice that emerged
      from a recent study of aspects of activity at a hospice in England. First, it is 
      suggested that researcher judgement in protecting participants from
      'overexposure' may have been insufficiently developed. Second, it is proposed
      that an unnecessarily individualist (biomedical) model of ethical good practice
      was uncritically accepted and that assumptions inherent in this approach should
      have been more thoroughly questioned. In conducting this study 'usual' measures
      were taken to protect from harm the individuals and organisation taking part.
      Before collecting data, which took the form of interview transcripts and notes
      made by the researcher in his role as staff nurse (participant observation),
      ethical approval was secured. Interviewees were known to the interviewer prior to
      interview.
FAU - Lipscomb, Martin
AU  - Lipscomb M
AD  - Faculty of Health and Life Sciences, School of Health and Social Care, University
      of the West of England.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurse Res
JT  - Nurse researcher
JID - 9435953
MH  - England
MH  - Ethics, Research
MH  - *Nursing Research
MH  - *Professional Role
MH  - *Research Personnel
EDAT- 2010/08/18 06:00
MHDA- 2010/09/04 06:00
CRDT- 2010/08/18 06:00
PHST- 2010/08/18 06:00 [entrez]
PHST- 2010/08/18 06:00 [pubmed]
PHST- 2010/09/04 06:00 [medline]
AID - 10.7748/nr2010.07.17.4.49.c7924 [doi]
PST - ppublish
SO  - Nurse Res. 2010;17(4):49-59. doi: 10.7748/nr2010.07.17.4.49.c7924.


PMID- 20711643
OWN - NLM
STAT- MEDLINE
DCOM- 20110429
LR  - 20220801
IS  - 1573-3572 (Electronic)
IS  - 1068-9583 (Linking)
VI  - 17
IP  - 4
DP  - 2010 Dec
TI  - 2020 foresight: practicing ethically while doing things that don't yet exist.
PG  - 278-84
LID - 10.1007/s10880-010-9204-5 [doi]
AB  - The APA Ethical Code struggles to offer guidance in the rapidly changing field of
      clinical health psychology. Professional challenges anticipated in the next
      decade are described, and their implications for ethical practice examined. This 
      paper is based in part on a presentation at the 2009 Conference at the
      Association of Psychologists in Academic Health Centers held in St. Louis,
      Missouri.
FAU - Linton, John C
AU  - Linton JC
AD  - West Virginia University School of Medicine, Charleston, WV, USA.
      jlinton@hsc.wvu.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Clin Psychol Med Settings
JT  - Journal of clinical psychology in medical settings
JID - 9435680
SB  - IM
MH  - Academic Medical Centers
MH  - Codes of Ethics
MH  - Humans
MH  - Physician's Role
MH  - Psychology, Clinical/*ethics/*trends
MH  - Societies, Scientific
MH  - United States
EDAT- 2010/08/17 06:00
MHDA- 2011/04/30 06:00
CRDT- 2010/08/17 06:00
PHST- 2010/08/17 06:00 [entrez]
PHST- 2010/08/17 06:00 [pubmed]
PHST- 2011/04/30 06:00 [medline]
AID - 10.1007/s10880-010-9204-5 [doi]
PST - ppublish
SO  - J Clin Psychol Med Settings. 2010 Dec;17(4):278-84. doi:
      10.1007/s10880-010-9204-5.


PMID- 20711633
OWN - NLM
STAT- MEDLINE
DCOM- 20110613
LR  - 20211020
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 22
IP  - 4
DP  - 2010 Dec
TI  - Conditional preferences and refusal of treatment.
PG  - 299-309
LID - 10.1007/s10730-010-9133-6 [doi]
AB  - In this essay, I will use a minimalist standard of decision-making capacity (DMC)
      to ascertain two cases in the medical ethics literature: the 1978 case of Mary C.
      Northern and a more recent case involving a paranoid war veteran (call him Jack).
      In both cases the patients refuse medical treatment out of denial that they are
      genuinely ill. I believe these cases illustrate two matters: (1) the need of
      holding oneself to a minimal DMC standard so as to make as salient as possible
      the patient's own reasons for sometimes unusual treatment denials; (2) the need
      for clinicians and other relevant parties to exercise great sensitivity toward
      engaging, on the patient's own terms, idiosyncratic treatment refusals through
      regard for what I will call the patient's "conditional preferences." These are
      particularly relevant matters when a patient's DMC is questionable yet he/she
      registers what may well be his/her settled preferences.
FAU - Glod, William
AU  - Glod W
AD  - bglod@ihs.gmu.edu
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - Aged
MH  - Aged, 80 and over
MH  - Decision Making/ethics
MH  - Delusions
MH  - Female
MH  - Humans
MH  - Informed Consent
MH  - Male
MH  - Mental Competency
MH  - Paternalism/ethics
MH  - Treatment Refusal/*ethics/psychology
EDAT- 2010/08/17 06:00
MHDA- 2011/06/15 06:00
CRDT- 2010/08/17 06:00
PHST- 2010/08/17 06:00 [entrez]
PHST- 2010/08/17 06:00 [pubmed]
PHST- 2011/06/15 06:00 [medline]
AID - 10.1007/s10730-010-9133-6 [doi]
PST - ppublish
SO  - HEC Forum. 2010 Dec;22(4):299-309. doi: 10.1007/s10730-010-9133-6.


PMID- 20711540
OWN - NLM
STAT- MEDLINE
DCOM- 20110617
LR  - 20200413
IS  - 1678-4782 (Electronic)
IS  - 0021-7557 (Linking)
VI  - 86
IP  - 4
DP  - 2010 Jul-Aug
TI  - Determinants of overweight in children under 4 years of age.
PG  - 311-6
LID - 10.2223/JPED.2009 [doi]
AB  - OBJECTIVES: To describe the prevalence of and factors associated with overweight 
      in children under 4 years of age in Feira de Santana, state of Bahia, Brazil.
      METHODS: Cross-sectional study nested within a birth cohort of 793 children born 
      in Feira de Santana, Brazil. Independent variables were related to infant
      characteristics, social and demographic factors, maternal reproductive aspects,
      and diet of the child at age 4 months. The dependent variable was nutritional
      status, as assessed by weight-for-height ratio compared to Multicentre Growth
      Reference Study standards and obtained with the use of the software ANTHRO.
      Z-scores of -2 and +2 above or below the median for the reference population were
      established as normality cutoff points. Child height and weight were measured
      with an anthropometer and digital scales, respectively; all measurements were
      taken in triplicate. The study was approved by the Research Ethics Committee of
      the Universidade Estadual de Feira de Santana (CEP/UEFS), under registration
      number 096/2006. RESULTS: The prevalence of overweight was 12.5%. Adequate birth 
      weight (RR 2.75; 95%CI 1.50-5.05), primiparity (RR 1.61; 95%CI 1.09-2.35), and
      maternal employment outside the home at age 4 months (RR 1.73; 95%CI 1.16-2.59)
      were associated with overweight. CONCLUSIONS: In this study, adequate birth
      weight, primiparity and maternal employment outside the home were associated with
      overweight in children. The rate of overweight found, which surpassed that
      reported by other studies conducted across the country (including Bahia), point
      to a risk of child obesity in Feira de Santana.
FAU - Jesus, Gilmar M de
AU  - Jesus GM
AD  - Universidade Estadual de Feira de Santana, Feira de Santana, BA, Brazil.
      gilmj@yahoo.com.br
FAU - Vieira, Graciete O
AU  - Vieira GO
FAU - Vieira, Tatiana O
AU  - Vieira TO
FAU - Martins, Camila da Cruz
AU  - Martins Cda C
FAU - Mendes, Carlos Mauricio Cardeal
AU  - Mendes CM
FAU - Castelao, Elizia S
AU  - Castelao ES
LA  - eng
LA  - por
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Brazil
TA  - J Pediatr (Rio J)
JT  - Jornal de pediatria
JID - 2985188R
SB  - IM
MH  - Brazil/epidemiology
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Nutritional Status/physiology
MH  - Overweight/*epidemiology/*etiology
MH  - Prevalence
MH  - Reference Values
MH  - Risk Factors
EDAT- 2010/08/17 06:00
MHDA- 2011/06/18 06:00
CRDT- 2010/08/17 06:00
PHST- 2009/04/27 00:00 [received]
PHST- 2010/04/07 00:00 [accepted]
PHST- 2010/08/17 06:00 [entrez]
PHST- 2010/08/17 06:00 [pubmed]
PHST- 2011/06/18 06:00 [medline]
AID - 10.2223/JPED.2009 [doi]
PST - ppublish
SO  - J Pediatr (Rio J). 2010 Jul-Aug;86(4):311-6. doi: 10.2223/JPED.2009.


PMID- 20711358
OWN - NLM
STAT- MEDLINE
DCOM- 20101228
LR  - 20211028
IS  - 1553-7404 (Electronic)
IS  - 1553-7390 (Linking)
VI  - 6
IP  - 8
DP  - 2010 Aug 12
TI  - Transmission of mitochondrial DNA diseases and ways to prevent them.
LID - 10.1371/journal.pgen.1001066 [doi]
LID - e1001066 [pii]
AB  - Recent reports of strong selection of mitochondrial DNA (mtDNA) during
      transmission in animal models of mtDNA disease, and of nuclear transfer in both
      animal models and humans, have important scientific implications. These are
      directly applicable to the genetic management of mtDNA disease. The risk that a
      mitochondrial disorder will be transmitted is difficult to estimate due to
      heteroplasmy-the existence of normal and mutant mtDNA in the same individual,
      tissue, or cell. In addition, the mtDNA bottleneck during oogenesis frequently
      results in dramatic and unpredictable inter-generational fluctuations in the
      proportions of mutant and wild-type mtDNA. Pre-implantation genetic diagnosis
      (PGD) for mtDNA disease enables embryos produced by in vitro fertilization (IVF) 
      to be screened for mtDNA mutations. Embryos determined to be at low risk (i.e.,
      those having low mutant mtDNA load) can be preferentially transferred to the
      uterus with the aim of initiating unaffected pregnancies. New evidence that some 
      types of deleterious mtDNA mutations are eliminated within a few generations
      suggests that women undergoing PGD have a reasonable chance of generating embryos
      with a lower mutant load than their own. While nuclear transfer may become an
      alternative approach in future, there might be more difficulties, ethical as well
      as technical. This Review outlines the implications of recent advances for
      genetic management of these potentially devastating disorders.
FAU - Poulton, Joanna
AU  - Poulton J
AD  - Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, 
      UK. Joanna.Poulton@obs-gyn.ox.ac.uk
FAU - Chiaratti, Marcos R
AU  - Chiaratti MR
FAU - Meirelles, Flavio V
AU  - Meirelles FV
FAU - Kennedy, Stephen
AU  - Kennedy S
FAU - Wells, Dagan
AU  - Wells D
FAU - Holt, Ian J
AU  - Holt IJ
LA  - eng
GR  - G0500695/MRC_/Medical Research Council/United Kingdom
GR  - MC_U105663140/MRC_/Medical Research Council/United Kingdom
GR  - DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100812
PL  - United States
TA  - PLoS Genet
JT  - PLoS genetics
JID - 101239074
RN  - 0 (DNA, Mitochondrial)
SB  - IM
MH  - Animals
MH  - DNA Mutational Analysis
MH  - DNA, Mitochondrial/*genetics
MH  - Genetic Counseling
MH  - Humans
MH  - Mice
MH  - Mitochondrial Diseases/diagnosis/*genetics/*prevention & control
PMC - PMC2920841
COIS- Oxford currently offers oocyte donation and oocyte sampling for mitochondrial DNA
      diseases. Preimplantation genetic diagnosis will be available in the near future.
      JP takes clinical and diagnostic referrals for the Oxford Centre in the Rare
      Mitochondrial Disorders Service for Adults and Children (NCG). Further
      information may be found on http://www.obs-gyn.ox.ac.uk/research/Poulton.
EDAT- 2010/08/17 06:00
MHDA- 2010/12/29 06:00
CRDT- 2010/08/17 06:00
PHST- 2010/08/17 06:00 [entrez]
PHST- 2010/08/17 06:00 [pubmed]
PHST- 2010/12/29 06:00 [medline]
AID - 10.1371/journal.pgen.1001066 [doi]
PST - epublish
SO  - PLoS Genet. 2010 Aug 12;6(8). doi: 10.1371/journal.pgen.1001066.


PMID- 20710129
OWN - NLM
STAT- MEDLINE
DCOM- 20100823
LR  - 20100816
IS  - 1541-8243 (Electronic)
IS  - 0038-4348 (Linking)
VI  - 103
IP  - 6
DP  - 2010 Jun
TI  - Are we providing ethical care for the severely obese?
PG  - 498-9
LID - 10.1097/SMJ.0b013e3181de01c6 [doi]
FAU - Reynolds, L Raymond
AU  - Reynolds LR
FAU - Rosenthal, M Sara
AU  - Rosenthal MS
LA  - eng
PT  - Editorial
PL  - United States
TA  - South Med J
JT  - Southern medical journal
JID - 0404522
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Bariatric Surgery/ethics
MH  - *Ethics, Medical
MH  - Health Services Accessibility/ethics
MH  - Humans
MH  - Informed Consent/ethics
MH  - Insurance Coverage/ethics
MH  - Obesity, Morbid/etiology/*therapy
MH  - Patient Education as Topic/ethics
MH  - Personal Autonomy
MH  - Physician's Role
MH  - *Prejudice
MH  - Resource Allocation/ethics
MH  - Stereotyping
MH  - United States
EDAT- 2010/08/17 06:00
MHDA- 2010/08/24 06:00
CRDT- 2010/08/17 06:00
PHST- 2010/08/17 06:00 [entrez]
PHST- 2010/08/17 06:00 [pubmed]
PHST- 2010/08/24 06:00 [medline]
AID - 10.1097/SMJ.0b013e3181de01c6 [doi]
AID - 00007611-201006000-00005 [pii]
PST - ppublish
SO  - South Med J. 2010 Jun;103(6):498-9. doi: 10.1097/SMJ.0b013e3181de01c6.


PMID- 20709723
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20220410
IS  - 1460-2210 (Electronic)
IS  - 0141-5387 (Linking)
VI  - 33
IP  - 2
DP  - 2011 Apr
TI  - Comparison of craniofacial characteristics of typical Chinese and Caucasian young
      adults.
PG  - 205-11
LID - 10.1093/ejo/cjq054 [doi]
AB  - The purpose of this study was to determine the cephalometric norms of typical
      Chinese young adult subjects with normal occlusions and well-balanced faces and
      to compare these norms with those derived from a matched Caucasian sample.
      Lateral cephalograms of 65 untreated Chinese adults (25 males, mean age 19.3 +/- 
      3.0 years and 40 females, mean age 20.3 +/- 3.4 years) were compared with a
      sample of 90 untreated Caucasian adults (30 males, mean age 24.1 +/- 5.7 years
      and 60 females, mean age 22.9 +/- 5.2 years). Each lateral cephalogram was traced
      and digitized, and conventional cephalometric analyses were applied. Independent 
      sample t-tests were used to compare the values between the two ethic samples.
      Smaller midfaces and shorter mandibles were observed in Chinese young adults
      compared with those of Caucasians. The average value of lower anterior face
      height (ANS-Me) was longer in the Chinese females than that in the Caucasian
      females (P < 0.001). A greater vertical dimension also was seen in Chinese males 
      compared with Caucasian males when evaluated by analysis of the facial axis angle
      (P < 0.05). The upper and lower lips were more protrusive in the Chinese, and a
      more convex facial profile was seen compared with the Caucasian sample.
      Significant differences in hard and soft tissue characteristics were found
      between Chinese and Caucasian young adults with normal occlusions and
      well-balanced faces. Gender and racial/ethnic differences must be taken into
      consideration during orthodontic diagnosis and treatment planning for the
      individual patient.
FAU - Gu, Yan
AU  - Gu Y
AD  - Department of Orthodontics, Peking University School and Hospital of Stomatology,
      Beijing, People's Republic of China. guyan99@yahoo.com
FAU - McNamara, James A Jr
AU  - McNamara JA Jr
FAU - Sigler, Lauren M
AU  - Sigler LM
FAU - Baccetti, Tiziano
AU  - Baccetti T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20100813
PL  - England
TA  - Eur J Orthod
JT  - European journal of orthodontics
JID - 7909010
SB  - IM
MH  - *Asians
MH  - Case-Control Studies
MH  - Cephalometry/*statistics & numerical data
MH  - Chin/anatomy & histology
MH  - China
MH  - Face/*anatomy & histology
MH  - Facial Bones/*anatomy & histology
MH  - Female
MH  - Humans
MH  - Incisor/anatomy & histology
MH  - Lip/anatomy & histology
MH  - Male
MH  - Mandible/anatomy & histology
MH  - Maxilla/anatomy & histology
MH  - Nasal Bone/anatomy & histology
MH  - Patient Care Planning
MH  - Reference Values
MH  - Sex Factors
MH  - Skull/*anatomy & histology
MH  - Vertical Dimension
MH  - *Whites
MH  - Young Adult
EDAT- 2010/08/17 06:00
MHDA- 2011/07/27 06:00
CRDT- 2010/08/17 06:00
PHST- 2010/08/17 06:00 [entrez]
PHST- 2010/08/17 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
AID - cjq054 [pii]
AID - 10.1093/ejo/cjq054 [doi]
PST - ppublish
SO  - Eur J Orthod. 2011 Apr;33(2):205-11. doi: 10.1093/ejo/cjq054. Epub 2010 Aug 13.


PMID- 20709469
OWN - NLM
STAT- MEDLINE
DCOM- 20110408
LR  - 20191210
IS  - 1531-6564 (Electronic)
IS  - 0363-5023 (Linking)
VI  - 35
IP  - 12
DP  - 2010 Dec
TI  - Current issues in the physician-patient relationship.
PG  - 2126-9
LID - 10.1016/j.jhsa.2010.06.012 [doi]
AB  - This review is one of a series of articles reflecting the sections of the Code of
      Ethics of the American Society for Surgery of the Hand. The physician-patient
      relationship has been subjected to numerous stressors over the past several
      decades. This report reviews historical elements of the relationship and
      discusses current issues related to it: asymmetry, challenges to the physician,
      and interpersonal, systemic, and societal challenges.
CI  - Copyright (c) 2010. Published by Elsevier Inc.
FAU - Kalliainen, Loree K
AU  - Kalliainen LK
AD  - Department of Plastic and Hand Surgery, Regions Hospital, St Paul, MN 55101, USA.
      loree.k.Kalliainen@healthpartners.com
FAU - Lichtman, David M
AU  - Lichtman DM
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100814
PL  - United States
TA  - J Hand Surg Am
JT  - The Journal of hand surgery
JID - 7609631
SB  - IM
MH  - Advertising
MH  - Communication
MH  - Cultural Diversity
MH  - Decision Making
MH  - Humans
MH  - Patient Satisfaction
MH  - *Physician-Patient Relations
MH  - Trust
EDAT- 2010/08/17 06:00
MHDA- 2011/04/09 06:00
CRDT- 2010/08/17 06:00
PHST- 2010/05/11 00:00 [received]
PHST- 2010/06/06 00:00 [accepted]
PHST- 2010/08/17 06:00 [entrez]
PHST- 2010/08/17 06:00 [pubmed]
PHST- 2011/04/09 06:00 [medline]
AID - S0363-5023(10)00662-3 [pii]
AID - 10.1016/j.jhsa.2010.06.012 [doi]
PST - ppublish
SO  - J Hand Surg Am. 2010 Dec;35(12):2126-9. doi: 10.1016/j.jhsa.2010.06.012. Epub
      2010 Aug 14.


PMID- 20709284
OWN - NLM
STAT- MEDLINE
DCOM- 20101105
LR  - 20111117
IS  - 1479-666X (Print)
IS  - 1479-666X (Linking)
VI  - 8
IP  - 5
DP  - 2010 Oct
TI  - Brain-machine interface: the challenge of neuroethics.
PG  - 267-9
LID - 10.1016/j.surge.2010.05.006 [doi]
AB  - The burning question surrounding the use of Brain-Machine Interface (BMI) devices
      is not merely whether they should be used, but how widely they should be used,
      especially in view of some ethical implications that arise concerning the social 
      and legal aspects of human life. As technology advances, it can be exploited to
      affect the quality of life. Since the effects of BMIs can be both positive and
      negative, it is imperative to address the issue of the ethics surrounding them.
      This paper presents the ways in which BMIs can be used and focuses on the ethical
      concerns to which neuroscience is thus exposed. The argument put forward supports
      the use of BMIs solely for purposes of medical treatment, and invites the legal
      framing of this.
CI  - Copyright (c) 2010 Royal College of Surgeons of Edinburgh (Scottish charity
      number SC005317) and Royal College of Surgeons in Ireland. Published by Elsevier 
      Ltd. All rights reserved.
FAU - Demetriades, Andreas K
AU  - Demetriades AK
AD  - Department of Neurosurgery, King's College Hospital, London SE5 9RS, UK.
      andreas.demetriades@gmail.com
FAU - Demetriades, Christina K
AU  - Demetriades CK
FAU - Watts, Colin
AU  - Watts C
FAU - Ashkan, Keyoumars
AU  - Ashkan K
LA  - eng
PT  - Journal Article
DEP - 20100713
PL  - Scotland
TA  - Surgeon
JT  - The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
JID - 101168329
SB  - IM
MH  - *Bioethical Issues
MH  - Humans
MH  - Medical Laboratory Science/*ethics
MH  - Neurosciences/*ethics
MH  - Prostheses and Implants/ethics
MH  - User-Computer Interface
EDAT- 2010/08/17 06:00
MHDA- 2010/11/06 06:00
CRDT- 2010/08/17 06:00
PHST- 2010/03/29 00:00 [received]
PHST- 2010/05/21 00:00 [accepted]
PHST- 2010/08/17 06:00 [entrez]
PHST- 2010/08/17 06:00 [pubmed]
PHST- 2010/11/06 06:00 [medline]
AID - S1479-666X(10)00150-2 [pii]
AID - 10.1016/j.surge.2010.05.006 [doi]
PST - ppublish
SO  - Surgeon. 2010 Oct;8(5):267-9. doi: 10.1016/j.surge.2010.05.006. Epub 2010 Jul 13.


PMID- 20708840
OWN - NLM
STAT- MEDLINE
DCOM- 20110208
LR  - 20191210
IS  - 1872-6968 (Electronic)
IS  - 0303-8467 (Linking)
VI  - 112
IP  - 10
DP  - 2010 Dec
TI  - Challenges to neurosurgical professionalism.
PG  - 839-43
LID - 10.1016/j.clineuro.2010.07.012 [doi]
AB  - At present, neurosurgical practice is confronted by an explosion of technology.
      Rapid advances in neurosurgical knowledge and technology are putting increased
      pressure on neurosurgeons to process huge quantities of information, with
      requirements for continuous learning and updating scientific knowledge and skills
      which are time consuming but essential. Changes to the venerated status quo of
      neurosurgical practice have created an environment that may have a negative
      impact upon neurosurgical professional behavior. As a result, neurosurgeons may
      find it increasingly difficult to meet their moral and ethical responsibilities
      to patients, trainees and colleagues, and society. In these circumstances,
      reaffirming the fundamental and universal principles and values of neurosurgical 
      professionalism, which remain the ideals to be pursued by all neurosurgeons,
      becomes all the more important.
CI  - Copyright (c) 2010. Published by Elsevier B.V.
FAU - Kanat, Ayhan
AU  - Kanat A
AD  - Rize University Medical School, Department of Neurosurgery, 53100 Rize, Turkey.
      ayhankanat@yahoo.com
FAU - Epstein, Clara Raquel
AU  - Epstein CR
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100813
PL  - Netherlands
TA  - Clin Neurol Neurosurg
JT  - Clinical neurology and neurosurgery
JID - 7502039
SB  - IM
MH  - Attitude of Health Personnel
MH  - Conflict of Interest
MH  - Morals
MH  - Neurosurgery/ethics/*standards/trends
MH  - Physician Impairment
MH  - Physician-Patient Relations
MH  - Power, Psychological
MH  - *Professional Role
EDAT- 2010/08/17 06:00
MHDA- 2011/02/09 06:00
CRDT- 2010/08/17 06:00
PHST- 2009/03/04 00:00 [received]
PHST- 2010/04/03 00:00 [revised]
PHST- 2010/07/16 00:00 [accepted]
PHST- 2010/08/17 06:00 [entrez]
PHST- 2010/08/17 06:00 [pubmed]
PHST- 2011/02/09 06:00 [medline]
AID - S0303-8467(10)00226-X [pii]
AID - 10.1016/j.clineuro.2010.07.012 [doi]
PST - ppublish
SO  - Clin Neurol Neurosurg. 2010 Dec;112(10):839-43. doi:
      10.1016/j.clineuro.2010.07.012. Epub 2010 Aug 13.


PMID- 20708331
OWN - NLM
STAT- MEDLINE
DCOM- 20110707
LR  - 20220317
IS  - 1873-7560 (Electronic)
IS  - 0302-2838 (Linking)
VI  - 58
IP  - 6
DP  - 2010 Dec
TI  - Randomized controlled trial of barbed polyglyconate versus polyglactin suture for
      robot-assisted laparoscopic prostatectomy anastomosis: technique and outcomes.
PG  - 875-81
LID - 10.1016/j.eururo.2010.07.021 [doi]
AB  - BACKGROUND: Transperitoneal robot-assisted laparoscopic prostatectomy (RALP)
      urethrovesical anastomosis is a critical step. Although the prevalence of urine
      leaks ranges from 4.5% to 7.5% at high-volume RALP centers, urine leaks prolong
      catheterization and may lead to ileus, peritonitis, and require intervention.
      Barbed polyglyconate sutures maintain running suture line tension and may be
      advantageous in RALP anastomosis for reducing this complication. OBJECTIVE: To
      compare barbed polyglyconate and polyglactin 910 (Vicryl, Ethicon, Somerville,
      NJ, USA) running sutures for RALP anastomosis. DESIGN, SETTING, AND PARTICIPANTS:
      This was a prospective, randomized, controlled, single-surgeon study comparing
      RALP anastomosis using either barbed polyglyconate (n = 45) or polyglactin 910 (n
      = 36) sutures. SURGICAL PROCEDURE: RALP anastomosis using either barbed
      polyglyconate or polyglactin 910 sutures was studied. MEASUREMENTS: Operative
      time, cost differential, perioperative complications, and cystogram contrast
      extravasation by anastomosis suture type were measured. RESULTS AND LIMITATIONS: 
      Although baseline characteristics and overall operative times were similar,
      barbed polyglyconate sutures were associated with shorter mean anastomosis times 
      of 9.7 min versus 9.8 min (p = 0.014). In addition, anastomosis with barbed
      polyglyconate rather than polyglactin 910 sutures was associated with more
      frequent cystogram extravasation 8 d postoperatively (20.0% vs 2.8%; p = 0.019), 
      longer mean catheterization times (11.1 d vs 8.3 d; p = 0.048), and greater
      suture costs per case ($51.52 vs $8.44; p < 0.001). After 8 of 29 (27.6%) barbed 
      polyglyconate anastomosis sites demonstrated postoperative day 8 cystogram
      extravasation, we modified our technique to avoid overtightening, reducing
      cystogram extravasation to 1 (6.3%) of 16 subsequent barbed polyglyconate
      anastomosis sites. Potential limitations include small sample size and the
      single-surgeon study design. CONCLUSIONS: Compared to traditional sutures, barbed
      polyglyconate is more costly and requires technical modification to avoid
      overtightening, delayed healing, and longer catheterization time following RALP.
CI  - Copyright (c) 2010 European Association of Urology. Published by Elsevier B.V.
      All rights reserved.
FAU - Williams, Stephen B
AU  - Williams SB
AD  - Division of Urologic Surgery, Brigham and Women's Hospital, Boston, MA, USA.
FAU - Alemozaffar, Mehrdad
AU  - Alemozaffar M
FAU - Lei, Yin
AU  - Lei Y
FAU - Hevelone, Nathanael
AU  - Hevelone N
FAU - Lipsitz, Stuart R
AU  - Lipsitz SR
FAU - Plaster, Blakely A
AU  - Plaster BA
FAU - Hu, Jim C
AU  - Hu JC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Video-Audio Media
DEP - 20100802
PL  - Switzerland
TA  - Eur Urol
JT  - European urology
JID - 7512719
RN  - 0 (Polymers)
RN  - 34346-01-5 (Polyglactin 910)
RN  - 75734-93-9 (polyglyconate)
SB  - IM
MH  - Aged
MH  - Anastomosis, Surgical
MH  - Boston
MH  - Chi-Square Distribution
MH  - Cost-Benefit Analysis
MH  - Hospital Costs
MH  - Humans
MH  - Laparoscopy/adverse effects/economics/*instrumentation
MH  - Male
MH  - Middle Aged
MH  - *Polyglactin 910/adverse effects/economics
MH  - *Polymers/adverse effects/economics
MH  - Prospective Studies
MH  - Prostatectomy/adverse effects/economics/*instrumentation/methods
MH  - Prostatic Neoplasms/economics/*surgery
MH  - Robotics/economics/*instrumentation
MH  - Surgery, Computer-Assisted/adverse effects/economics/*instrumentation
MH  - Suture Techniques/adverse effects/economics/*instrumentation
MH  - *Sutures/adverse effects/economics
MH  - Time Factors
MH  - Treatment Outcome
MH  - Urinary Catheterization
MH  - Wound Healing
EDAT- 2010/08/17 06:00
MHDA- 2011/07/08 06:00
CRDT- 2010/08/17 06:00
PHST- 2010/06/08 00:00 [received]
PHST- 2010/07/13 00:00 [accepted]
PHST- 2010/08/17 06:00 [entrez]
PHST- 2010/08/17 06:00 [pubmed]
PHST- 2011/07/08 06:00 [medline]
AID - S0302-2838(10)00682-2 [pii]
AID - 10.1016/j.eururo.2010.07.021 [doi]
PST - ppublish
SO  - Eur Urol. 2010 Dec;58(6):875-81. doi: 10.1016/j.eururo.2010.07.021. Epub 2010 Aug
      2.


PMID- 20707974
OWN - NLM
STAT- MEDLINE
DCOM- 20101029
LR  - 20100816
IS  - 1865-9217 (Print)
IS  - 1865-9217 (Linking)
VI  - 104
IP  - 5
DP  - 2010
TI  - [Dealing with bottlenecks in health care--ethical issues].
PG  - 360-4
LID - 10.1016/j.zefq.2010.06.003 [doi]
AB  - Due to the ageing of our society and the enduring progress of medicine it will no
      longer be possible to provide universal access to everything health care
      providers could potentially offer. Therefore, we need a debate on legitimate
      health care claims and fair distribution of medical resources under conditions of
      scarcity - hence on matters of social justice. This paper will look at some
      general ethical aspects and some specific proposals for fair criteria of
      rationing in health care.
CI  - Copyright (c) 2010. Published by Elsevier GmbH.
FAU - Schone-Seifert, Bettina
AU  - Schone-Seifert B
AD  - Institut fur Ethik, Geschichte und Theorie der Medizin, Universitat Munster.
      bseifert@uni-muenster.de
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Engpasse medizinischer Versorgung--Ethische Aspekte.
DEP - 20100618
PL  - Netherlands
TA  - Z Evid Fortbild Qual Gesundhwes
JT  - Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen
JID - 101477604
SB  - IM
MH  - Delivery of Health Care/ethics/*standards
MH  - *Ethics, Medical
MH  - Germany
MH  - Health Care Rationing/*economics/standards
MH  - Humans
MH  - Resource Allocation/ethics
EDAT- 2010/08/17 06:00
MHDA- 2010/10/30 06:00
CRDT- 2010/08/17 06:00
PHST- 2010/08/17 06:00 [entrez]
PHST- 2010/08/17 06:00 [pubmed]
PHST- 2010/10/30 06:00 [medline]
AID - S1865-9217(10)00139-X [pii]
AID - 10.1016/j.zefq.2010.06.003 [doi]
PST - ppublish
SO  - Z Evid Fortbild Qual Gesundhwes. 2010;104(5):360-4. doi:
      10.1016/j.zefq.2010.06.003. Epub 2010 Jun 18.


PMID- 20707973
OWN - NLM
STAT- MEDLINE
DCOM- 20101029
LR  - 20100816
IS  - 1865-9217 (Print)
IS  - 1865-9217 (Linking)
VI  - 104
IP  - 5
DP  - 2010
TI  - [Rationalisation, prioritisation and rationing: approaches to future health care 
      delivery].
PG  - 355-9
LID - 10.1016/j.zefq.2010.06.002 [doi]
AB  - Complex developments are increasing the gap between the financial feasibility of 
      the German health care system and new possibilities in diagnosis and therapy.
      Influencing factors, inter alia, include rapid medical progress, demographic and 
      epidemiological trends and changing perceptions of health and illness. This
      raises the question of how a just allocation of scarce resources can be developed
      and implemented. Concepts such as rationalisation, rationing and prioritisation
      are being intensively discussed. In this paper definitions of and
      differentiations between these terms will be presented, which are often missing
      from the current debate. Furthermore, the need for action implying ethical and
      structural-political challenges will be outlined. In this regard, a sustainable
      process should focus on transparency, responsibility and public involvement.
CI  - Copyright (c) 2010. Published by Elsevier GmbH.
FAU - Nagel, Eckhard
AU  - Nagel E
AD  - Universitat Bayreuth, Institut for Medizinmanagement und
      GEsundheitswissenschaften, Bayreuth. eckhard.nagel@uni-bayreuth.de
FAU - Alber, Kathrin
AU  - Alber K
FAU - Bayerl, Birgitta
AU  - Bayerl B
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Rationalisierung, Priorisierung und Rationierung--Konzepte zur
      Gesundheitsversorgung der Zukunft.
DEP - 20100807
PL  - Netherlands
TA  - Z Evid Fortbild Qual Gesundhwes
JT  - Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen
JID - 101477604
SB  - IM
MH  - Delivery of Health Care/*standards/trends
MH  - Disease
MH  - Germany
MH  - Health
MH  - Health Care Rationing/*economics
MH  - Humans
MH  - Perception
MH  - Politics
EDAT- 2010/08/17 06:00
MHDA- 2010/10/30 06:00
CRDT- 2010/08/17 06:00
PHST- 2010/08/17 06:00 [entrez]
PHST- 2010/08/17 06:00 [pubmed]
PHST- 2010/10/30 06:00 [medline]
AID - S1865-9217(10)00138-8 [pii]
AID - 10.1016/j.zefq.2010.06.002 [doi]
PST - ppublish
SO  - Z Evid Fortbild Qual Gesundhwes. 2010;104(5):355-9. doi:
      10.1016/j.zefq.2010.06.002. Epub 2010 Aug 7.


PMID- 20707083
OWN - NLM
STAT- MEDLINE
DCOM- 20100916
LR  - 20191111
IS  - 1001-5302 (Print)
IS  - 1001-5302 (Linking)
VI  - 35
IP  - 9
DP  - 2010 May
TI  - [Thinking of current situation about decreasing, abolishing and substitution of
      Chinese medicine species in Shanghanlun].
PG  - 1209-12
AB  - Currently, some Chinese medicine species in Shanghan Zabing Lun have been
      abolished or substituted, or the use frequency has decreased. In this article,
      the reason of these phenomenons has been analyzed. It might be connected with the
      intensive toxicity of the herb, deficiency of some valuable species and
      indefinite pharmacodynamic action mechanism. Even more, some species usage
      deviate from clinical ethics. Further more, the solution of the problem resulted 
      by above phenomena was proposed. To propose solutions from successive dynasty
      documents, clinical therapeutic effect verification and pharmaceutical research, 
      the enlargement of the use frequency for some species will come true. And some
      abolished species will be waken up to use in clinical. Those substituted herbs
      will be suitable for the practice better.
FAU - Ling, Yun
AU  - Ling Y
AD  - Preclinical Medicine College, Nanjing University of Chinese Medicine, Nanjing
      210046, China.
FAU - Zhou, Chunxiang
AU  - Zhou C
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Zhong Yao Za Zhi
JT  - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese
      materia medica
JID - 8913656
RN  - 0 (Drugs, Chinese Herbal)
SB  - IM
MH  - Drug Prescriptions/standards
MH  - Drug Therapy/*standards
MH  - Drugs, Chinese Herbal/*standards/therapeutic use
MH  - Humans
MH  - Medicine, Chinese Traditional/*standards
EDAT- 2010/08/17 06:00
MHDA- 2010/09/18 06:00
CRDT- 2010/08/17 06:00
PHST- 2010/08/17 06:00 [entrez]
PHST- 2010/08/17 06:00 [pubmed]
PHST- 2010/09/18 06:00 [medline]
AID - 10.4268/cjcmm20100926 [doi]
PST - ppublish
SO  - Zhongguo Zhong Yao Za Zhi. 2010 May;35(9):1209-12. doi: 10.4268/cjcmm20100926.


PMID- 20706992
OWN - NLM
STAT- MEDLINE
DCOM- 20110204
LR  - 20151119
IS  - 1542-0760 (Electronic)
IS  - 1542-0752 (Linking)
VI  - 88
IP  - 10
DP  - 2010 Oct
TI  - Maternal-infant biomonitoring of environmental chemicals: the epidemiologic
      challenges.
PG  - 931-7
LID - 10.1002/bdra.20694 [doi]
AB  - There is growing concern about the potential health effects of exposure to
      various environmental chemicals during pregnancy and infancy. One of the key
      limitations of past epidemiologic research in this field has been the potential
      for exposure misclassification to lead to biases in the health risk estimate. The
      use of biomarkers in pregnancy cohort or case-control studies has significantly
      advanced the field; however, this is true only if the biomarker is a true
      measurement of exposure for the relevant time period of interest. There are a
      number of theoretical and practical constraints to their use, including
      difficulty interpreting biomonitoring data, high analytical and collection costs,
      potential participant selection biases, and ethical challenges in reporting
      results to study subjects. Identifying a representative sample and collecting
      biospecimens in the developmental window of interest can be problematic. Various 
      strategies for identifying pregnant women range from the more representative but 
      least efficient sampling of the general population to recruitment through early
      ultrasound clinics and local advertising. Whereas measurement of xenobiotic
      chemicals in cord blood, amniotic fluid, or meconium provides unequivocal
      evidence that the chemical has entered the fetal environment, analysis of
      maternal blood and urine can be used as a surrogate for fetal exposure. Use of
      stored midpregnancy serum collected for fetal screening and of large-cohort
      biobanks offer unique opportunities for biomonitoring data for birth defects
      studies. Future research is needed to explore less invasive matrices for
      biomonitoring of infants and to develop less costly analytical methods that
      require smaller sample volumes.
CI  - (c) 2010 Wiley-Liss, Inc.
FAU - Arbuckle, Tye E
AU  - Arbuckle TE
AD  - Environmental Health Science and Research Bureau, Health Canada, 50 Colombine
      Drive, A.L. 0801A Tunney's Pasture, Ottawa, Ontario, Canada.
      Tye.Arbuckle@hc-sc.gc.ca
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Birth Defects Res A Clin Mol Teratol
JT  - Birth defects research. Part A, Clinical and molecular teratology
JID - 101155107
RN  - 0 (Biomarkers)
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - *Biomarkers
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Congenital Abnormalities/*epidemiology
MH  - Environmental Monitoring/*methods
MH  - Environmental Pollutants/blood/*toxicity/urine
MH  - Epidemiological Monitoring
MH  - Female
MH  - Humans
MH  - Infant
MH  - *Maternal Exposure
MH  - Pregnancy
EDAT- 2010/08/14 06:00
MHDA- 2011/02/05 06:00
CRDT- 2010/08/14 06:00
PHST- 2010/08/14 06:00 [entrez]
PHST- 2010/08/14 06:00 [pubmed]
PHST- 2011/02/05 06:00 [medline]
AID - 10.1002/bdra.20694 [doi]
PST - ppublish
SO  - Birth Defects Res A Clin Mol Teratol. 2010 Oct;88(10):931-7. doi:
      10.1002/bdra.20694.


PMID- 20706163
OWN - NLM
STAT- MEDLINE
DCOM- 20100913
LR  - 20211020
IS  - 1537-1948 (Electronic)
IS  - 0025-7079 (Linking)
VI  - 48
IP  - 9
DP  - 2010 Sep
TI  - The role of ethics committees and ethics consultation in allocation decisions: a 
      4-stage process.
PG  - 821-6
LID - 10.1097/MLR.0b013e3181e577fb [doi]
AB  - BACKGROUND: Decisions about the allocation and rationing of medical interventions
      likely occur in all health care systems worldwide. So far very little attention
      has been given to the question of what role ethics consultation and ethics
      committees could or should play in questions of allocation at the hospital level.
      OBJECTIVES AND METHODS: This article argues for the need for ethics consultation 
      in rationing decisions using empirical data about the status quo and the inherent
      nature of bedside rationing. Subsequently, it introduces a 4-stage process for
      establishing and conducting ethics consultation in rationing questions with
      systematic reference to core elements of procedural justice. RESULTS: Qualitative
      and quantitative findings show a significant demand for ethics consultation
      expressed directly by doctors, as well as additional indirect evidence of such a 
      need as indicated by ethically challenging circumstances of inconsistent and
      structurally disadvantaging rationing decisions. To address this need, we suggest
      4 stages for establishing and conducting ethics consultation in rationing
      questions we recommend: (1) training, (2) identifying actual scarcity-related
      problems at clinics, (3) supporting decision-making, and (4) evaluation.
      CONCLUSION: This process of ethics consultation regarding rationing decisions
      would facilitate the achievement of several practical goals: (i) encouragement of
      an awareness and understanding of ethical problems in bedside rationing, (ii)
      encouragement of achieving efficiency along with rationing, (iii) reinforcement
      of consistency in inter- and intraindividual decision-making, (iv) encouragement 
      of explicit reflection and justification of the prioritization criteria taken
      into consideration, (v) improvement in internal (in-house) and external
      transparency, and (vi) prevention of the misuse of the corresponding consulting
      structures.
FAU - Strech, Daniel
AU  - Strech D
AD  - Institute for History, Ethics, and Philosophy of Medicine, Centre of Public
      Health and Healthcare, Hannover Medical School, Hannover, Germany.
      strech.daniel@mh-hannover.de
FAU - Hurst, Samia
AU  - Hurst S
FAU - Danis, Marion
AU  - Danis M
LA  - eng
GR  - Z99 CL999999/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Med Care
JT  - Medical care
JID - 0230027
SB  - IM
MH  - *Ethics Committees
MH  - Ethics Consultation/*organization & administration
MH  - Europe
MH  - Health Care Rationing/*ethics
MH  - Hospital Administration
MH  - Humans
MH  - *Role
MH  - Surveys and Questionnaires
PMC - PMC3622545
MID - NIHMS456076
EDAT- 2010/08/14 06:00
MHDA- 2010/09/14 06:00
CRDT- 2010/08/14 06:00
PHST- 2010/08/14 06:00 [entrez]
PHST- 2010/08/14 06:00 [pubmed]
PHST- 2010/09/14 06:00 [medline]
AID - 10.1097/MLR.0b013e3181e577fb [doi]
PST - ppublish
SO  - Med Care. 2010 Sep;48(9):821-6. doi: 10.1097/MLR.0b013e3181e577fb.


PMID- 20705637
OWN - NLM
STAT- MEDLINE
DCOM- 20110315
LR  - 20101124
IS  - 1468-2060 (Electronic)
IS  - 0003-4967 (Linking)
VI  - 69
IP  - 12
DP  - 2010 Dec
TI  - Use of TNF blockers and other targeted therapies in rare refractory
      immune-mediated inflammatory diseases: evidence-based or rational?
PG  - 2067-73
LID - 10.1136/ard.2009.126813 [doi]
AB  - Evidence-based medicine implies that clinical decision making should be based on 
      external research evidence when available. This external evidence includes, but
      is certainly not restricted to, randomised controlled trials (RCTs). The
      development of powerful but often expensive targeted therapies for
      immune-mediated inflammatory diseases (IMIDs) is one of the major successes of
      evidence-based medicine but, paradoxically, also threatens the traditional
      RCT-based approach. Indeed, the increasing availability of these drugs decreases 
      the number of patients available for RCTs, questions the ethical basis for the
      use of placebo groups and raises the issue of cost-efficacy. These considerations
      become even more important in rare phenotypically diverse and potentially life-
      or organ-threatening IMIDs such as sarcoidosis, Behcet's disease and uveitis.
      Using the successful application of tumour necrosis factor blockade in these
      diseases as an example, this review defends the concept that pathophysiological
      insights in cellular and molecular disease pathways as well as limited case
      series are valid sources of external evidence for the rational use of targeted
      therapies in these rare refractory conditions. If authors fail to redefine their 
      concept of rational therapy along the lines of not only evidence-based but also
      pathophysiology-based and practice-based medicine, they may underestimate the
      potential of novel drugs in rare refractory IMIDs and thereby jeopardise the
      health of their patients.
FAU - Baeten, Dominique
AU  - Baeten D
AD  - Clinical Immunology and Rheumatology, Academic Medical Center/University of
      Amsterdam, Amsterdam, The Netherlands. d.l.baeten@amc.uva.nl
FAU - van Hagen, P Martin
AU  - van Hagen PM
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100812
PL  - England
TA  - Ann Rheum Dis
JT  - Annals of the rheumatic diseases
JID - 0372355
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Behcet Syndrome/drug therapy
MH  - Evidence-Based Medicine/methods
MH  - Humans
MH  - Immune System Diseases/*drug therapy
MH  - Inflammation/*drug therapy
MH  - Rare Diseases/drug therapy
MH  - Sarcoidosis/drug therapy
MH  - Tumor Necrosis Factor-alpha/*antagonists & inhibitors
MH  - Uveitis/drug therapy
EDAT- 2010/08/14 06:00
MHDA- 2011/03/16 06:00
CRDT- 2010/08/14 06:00
PHST- 2010/08/14 06:00 [entrez]
PHST- 2010/08/14 06:00 [pubmed]
PHST- 2011/03/16 06:00 [medline]
AID - ard.2009.126813 [pii]
AID - 10.1136/ard.2009.126813 [doi]
PST - ppublish
SO  - Ann Rheum Dis. 2010 Dec;69(12):2067-73. doi: 10.1136/ard.2009.126813. Epub 2010
      Aug 12.


PMID- 20705232
OWN - NLM
STAT- MEDLINE
DCOM- 20101122
LR  - 20100813
IS  - 1873-6513 (Electronic)
IS  - 0885-3924 (Linking)
VI  - 40
IP  - 2
DP  - 2010 Aug
TI  - Brain death: ethical challenges to palliative care concepts of family care.
PG  - 309-13
LID - 10.1016/j.jpainsymman.2010.02.016 [doi]
AB  - Brain death is a controversial issue that is often difficult for families to
      understand or accept. Palliative care interventions can help families to accept
      the death. However, delaying pronouncement of brain death may be detrimental to
      the family and lead to financial, ethical, and legal complications, including the
      potential for insurance fraud. We describe a case of brain death in which the
      passage of time along with continuation of life support without concomitant
      testing for brain death led to decreased acceptance of the patient's death by the
      family. Clinicians should weigh the risks and benefits of harm to the family when
      deciding how long to keep a brain dead patient on a ventilator. Pronouncement of 
      death, which is good basic medical care regardless of the cause or mechanism of
      death, should not be delayed for family considerations. Risk management should be
      involved early in the decision process, if life support is withdrawn without the 
      family's assent.
CI  - Copyright (c) 2010 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. 
      All rights reserved.
FAU - Liao, Solomon
AU  - Liao S
AD  - University of California, Irvine, California 92868, USA. ssliao@uci.edu
FAU - Ito, Shiho
AU  - Ito S
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Pain Symptom Manage
JT  - Journal of pain and symptom management
JID - 8605836
SB  - IM
MH  - *Brain Death
MH  - Family
MH  - Humans
MH  - Life Support Care/ethics
MH  - Male
MH  - Middle Aged
MH  - Palliative Care/*ethics
EDAT- 2010/08/14 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/14 06:00
PHST- 2009/11/11 00:00 [received]
PHST- 2010/02/07 00:00 [revised]
PHST- 2010/02/08 00:00 [accepted]
PHST- 2010/08/14 06:00 [entrez]
PHST- 2010/08/14 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S0885-3924(10)00454-9 [pii]
AID - 10.1016/j.jpainsymman.2010.02.016 [doi]
PST - ppublish
SO  - J Pain Symptom Manage. 2010 Aug;40(2):309-13. doi:
      10.1016/j.jpainsymman.2010.02.016.


PMID- 20705206
OWN - NLM
STAT- MEDLINE
DCOM- 20101115
LR  - 20100813
IS  - 1873-2518 (Electronic)
IS  - 0264-410X (Linking)
VI  - 28
IP  - 36
DP  - 2010 Aug 16
TI  - Mandating influenza vaccination for health care workers: putting patients and
      professional ethics over personal preference.
PG  - 5757-9
LID - 10.1016/j.vaccine.2010.07.057 [doi]
FAU - Poland, Gregory A
AU  - Poland GA
LA  - eng
PT  - Editorial
PL  - Netherlands
TA  - Vaccine
JT  - Vaccine
JID - 8406899
RN  - 0 (Influenza Vaccines)
SB  - IM
MH  - Health Personnel/*ethics
MH  - Health Policy
MH  - Humans
MH  - Influenza Vaccines/*administration & dosage
MH  - Influenza, Human/*prevention & control
MH  - Mandatory Programs/*ethics
MH  - Vaccination/*ethics
EDAT- 2010/08/14 06:00
MHDA- 2010/11/16 06:00
CRDT- 2010/08/14 06:00
PHST- 2010/07/13 00:00 [received]
PHST- 2010/07/13 00:00 [accepted]
PHST- 2010/08/14 06:00 [entrez]
PHST- 2010/08/14 06:00 [pubmed]
PHST- 2010/11/16 06:00 [medline]
AID - S0264-410X(10)01055-8 [pii]
AID - 10.1016/j.vaccine.2010.07.057 [doi]
PST - ppublish
SO  - Vaccine. 2010 Aug 16;28(36):5757-9. doi: 10.1016/j.vaccine.2010.07.057.


PMID- 20704792
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20100813
IS  - 1008-8830 (Print)
IS  - 1008-8830 (Linking)
VI  - 12
IP  - 8
DP  - 2010 Aug
TI  - [Prevalence of upper respiratory tract group A Streptococcus carriage in
      school-age children from Tulufan City and Buerjin County of Xinjiang Province].
PG  - 616-8
AB  - OBJECTIVE: To study the prevalence rate of upper respiratory tract group A
      Streptococcus (GAS) carriage in school-age children from Xinjiang Province.
      METHODS: A total of 478 children at age of 9-12 years from Tulufan City and
      Buerjin County of Xinjiang Province were enrolled by random cluster sampling.
      Throat swab cultures were performed once each season for the determination of
      presence of GAS. RESULTS: In the 1 827 samples, 196 GAS strains were isolated,
      with a GAS carrier rate of 10.7%. The prevalence rate of GAS carrier in Tulufan
      City ranged from 3.7%-16.5% compared with 4.7%-21.4% in Buerjin County (P <
      0.05). The prevalence rate of GAS carrier in winter is the highest, followed by
      in autumn, spring and summer in both regions. There were significant differences 
      in the GAS carriage rate in autumn between the two regions. There were no
      significant differences in the GAS carriage rate between boys and girls. Of the
      196 GAS strains, 133 from Han, 22 from Uygur and 41 from Hazakh children. There
      were significant differences in the prevalence rate of GAS carriage among
      children with different ethic groups. CONCLUSIONS: The prevalence rate of GAS
      carriage is high in school-age children from Tulufan and Buerjin of Xinjiang
      Province. The GAS carrier rate is associated with the season and ethic group. The
      children from Buerjin County present a higher GAS carrier rate than those from
      Tulufan City.
FAU - Sha, Kan
AU  - Sha K
AD  - First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
FAU - Xu, Pei-Ru
AU  - Xu PR
FAU - Duo, Li-Kun
AU  - Duo LK
FAU - Gu, Li-Ba-Ha
AU  - Gu LB
FAU - Gao, Xiao-Mei
AU  - Gao XM
FAU - Ji, Ping
AU  - Ji P
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Dang Dai Er Ke Za Zhi
JT  - Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
JID - 100909956
SB  - IM
MH  - Carrier State/*microbiology
MH  - Child
MH  - China
MH  - Female
MH  - Humans
MH  - Male
MH  - Prevalence
MH  - Respiratory System/*microbiology
MH  - Streptococcus pyogenes/*isolation & purification
EDAT- 2010/08/14 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/08/14 06:00
PHST- 2010/08/14 06:00 [entrez]
PHST- 2010/08/14 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - 1008-8830(2010)08-0616-03 [pii]
PST - ppublish
SO  - Zhongguo Dang Dai Er Ke Za Zhi. 2010 Aug;12(8):616-8.


PMID- 20703812
OWN - NLM
STAT- MEDLINE
DCOM- 20111205
LR  - 20211020
IS  - 1573-739X (Electronic)
IS  - 0928-1231 (Linking)
VI  - 32
IP  - 6
DP  - 2010 Dec
TI  - Managing obesity in pharmacy: the Australian experience.
PG  - 711-20
LID - 10.1007/s11096-010-9426-5 [doi]
AB  - OBJECTIVE: To explore pharmacists' opinions about the provision of weight
      management services in community pharmacy and their attitudes towards the
      establishment of an accredited training course in weight management in pharmacy. 
      SETTING: Interviews were conducted with practising pharmacists on site in various
      community pharmacies in metropolitan Sydney, Australia. METHOD: In-depth,
      semi-structured interviews with twenty practising pharmacists were conducted. Of 
      the twenty interviewed pharmacists, sixteen were involved in the provision of one
      or more pharmacy based weight management programs in their pharmacies. Interviews
      were audio-recorded, transcribed and analysed using the grounded theory approach.
      MAIN OUTCOME MEASURE: The data were thematically analysed to identify
      facilitators and perceived barriers to the provision of high quality services,
      and pharmacists' willingness to undertake training and accreditation. RESULTS:
      Participants clearly perceived a role for pharmacy in weight management. Key
      facilitators to provision of service were accessibility and the perception of
      pharmacists as trustworthy healthcare professionals. The pharmacists proposed
      collaboration with other healthcare professionals in order to provide a service
      incorporating diet, exercise and behavioural therapy. A program that was
      not-product-centred, and supported by ethical marketing was favoured. Appropriate
      training and accreditation were considered essential to assuring the quality of
      such services. Barriers to the provision of high quality services identified
      were: remuneration, pharmacy infrastructure, client demand and the current
      marketing of product-centred programs. CONCLUSION: Australian pharmacists believe
      there is a role for pharmacy in weight management, provided training in
      accredited programs is made available. A holistic, evidence-based,
      multi-disciplinary service model has been identified as ideal.
FAU - Um, Irene S I
AU  - Um IS
AD  - Faculty of Pharmacy, The University of Sydney, N508, Pharmacy and Bank Building
      A15, Sydney, NSW, 2006, Australia.
FAU - Armour, Carol
AU  - Armour C
FAU - Krass, Ines
AU  - Krass I
FAU - Gill, Timothy
AU  - Gill T
FAU - Chaar, Betty B
AU  - Chaar BB
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20100812
PL  - Germany
TA  - Pharm World Sci
JT  - Pharmacy world & science : PWS
JID - 9307352
SB  - IM
MH  - Australia/epidemiology
MH  - *Community Pharmacy Services
MH  - Disease Management
MH  - Follow-Up Studies
MH  - Humans
MH  - Obesity/*epidemiology/*therapy
MH  - *Pharmacists
MH  - *Professional Role
EDAT- 2010/08/13 06:00
MHDA- 2011/12/13 00:00
CRDT- 2010/08/13 06:00
PHST- 2010/02/24 00:00 [received]
PHST- 2010/08/02 00:00 [accepted]
PHST- 2010/08/13 06:00 [entrez]
PHST- 2010/08/13 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/s11096-010-9426-5 [doi]
PST - ppublish
SO  - Pharm World Sci. 2010 Dec;32(6):711-20. doi: 10.1007/s11096-010-9426-5. Epub 2010
      Aug 12.


PMID- 20703441
OWN - NLM
STAT- MEDLINE
DCOM- 20110107
LR  - 20211020
IS  - 1432-055X (Electronic)
IS  - 0003-2417 (Linking)
VI  - 59
IP  - 9
DP  - 2010 Sep
TI  - [Direct laryngoscopy or C-MAC video laryngoscopy? Routine tracheal intubation in 
      patients undergoing ENT surgery].
PG  - 806-11
LID - 10.1007/s00101-010-1753-3 [doi]
AB  - BACKGROUND: Previous studies have shown that video laryngoscopy enhances
      laryngeal view in patients with apparently normal and difficult airways. The
      utility of the novel, portable, battery-powered C-MAC video laryngoscope is as
      yet unproven. It was hypothesized that in routine patients undergoing ENT
      surgery, the rate of glottic views considered unsatisfactory, i.e. Cormack and
      Lehane grades IIb, III, and IV, could be significantly reduced with the C-MAC
      video laryngoscope compared to direct laryngoscopy. METHODS: Following ethical
      approval and sample size estimates 108 consecutive patients undergoing ENT
      surgery under general anesthesia were studied. First, direct laryngoscopy was
      performed with the naked eye. The best view obtained was graded by the first
      anesthesiologist without looking at the video monitor. A second anesthesiologist 
      blinded to the laryngeal view obtained under direct laryngoscopy graded the
      laryngeal view on the video monitor. Endotracheal intubation using
      Ring-Adair-Elwyn (RAE) tracheal tubes was then attempted under video-aided
      visualization. The tubes were not reinforced with a stylet. The C-MAC video
      laryngoscopy system (Karl Storz, Tuttlingen, Germany) is a novel device that can 
      be used with Macintosh laryngoscope blades in different sizes. A camera and light
      source are located recessed from the tip of the blade. The camera unit sits in a 
      handle attached to the laryngoscope blade and is connected by a wire to a TFT
      video monitor. It allows for both direct and indirect laryngoscopy and the low
      profile of the original British Macintosh blades may prove advantageous in
      patients with limited mouth opening. RESULTS: A total of 108 patients were
      enrolled in the study but for various reasons only 94 completed the study (post
      hoc power 97%). In 89 patients a size 3 Macintosh laryngoscope was used while a
      size 4 blade was used in the remaining 5 patients. With direct laryngoscopy the
      glottic view was considered unsatisfactory in 40 patients (42%), but this was the
      case in only 15 patients (16%) when video laryngoscopy was used (p<0.0001).
      Endotracheal tube placement was successful in all but one patient where the
      Bonfils intubation fiberscope needed to be employed. No complications related to 
      the C-MAC system were observed. CONCLUSIONS: Compared to direct laryngoscopy with
      a Macintosh laryngoscope blade in unselected patients undergoing ENT surgery and 
      thus patients more susceptible to an unexpected difficult airway than a general
      patient population, the mobile C-MAC video laryngoscope significantly enhanced
      laryngeal view. Using RAE tracheal tubes seems to compensate the unfavorable
      deviation of optical and anatomical axes when indirect laryngoscopy is performed 
      with the C-MAC system.
FAU - Meininger, D
AU  - Meininger D
AD  - Klinik fur Anasthesiologie, Intensivmedizin und Schmerztherapie, Klinikum der J W
      Goethe-Universitat Frankfurt am Main.
FAU - Strouhal, U
AU  - Strouhal U
FAU - Weber, C F
AU  - Weber CF
FAU - Fogl, D
AU  - Fogl D
FAU - Holzer, L
AU  - Holzer L
FAU - Zacharowski, K
AU  - Zacharowski K
FAU - Byhahn, C
AU  - Byhahn C
LA  - ger
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
TT  - Direkte Laryngoskopie oder C-MAC-Videolaryngoskopie? Routineintubation von
      Patienten in der HNO-Heilkunde.
DEP - 20100813
PL  - Germany
TA  - Anaesthesist
JT  - Der Anaesthesist
JID - 0370525
SB  - IM
MH  - Adult
MH  - Female
MH  - Glottis/anatomy & histology
MH  - Humans
MH  - *Intubation, Intratracheal
MH  - *Laryngoscopes
MH  - *Laryngoscopy
MH  - Male
MH  - Middle Aged
MH  - *Otorhinolaryngologic Surgical Procedures
MH  - Video-Assisted Surgery
EDAT- 2010/08/13 06:00
MHDA- 2011/01/08 06:00
CRDT- 2010/08/13 06:00
PHST- 2010/04/22 00:00 [received]
PHST- 2010/05/26 00:00 [accepted]
PHST- 2010/05/20 00:00 [revised]
PHST- 2010/08/13 06:00 [entrez]
PHST- 2010/08/13 06:00 [pubmed]
PHST- 2011/01/08 06:00 [medline]
AID - 10.1007/s00101-010-1753-3 [doi]
PST - ppublish
SO  - Anaesthesist. 2010 Sep;59(9):806-11. doi: 10.1007/s00101-010-1753-3. Epub 2010
      Aug 13.


PMID- 20703251
OWN - NLM
STAT- MEDLINE
DCOM- 20100903
LR  - 20220316
IS  - 1474-1768 (Electronic)
IS  - 1474-175X (Linking)
VI  - 10
IP  - 9
DP  - 2010 Sep
TI  - Integrating biobanks: addressing the practical and ethical issues to deliver a
      valuable tool for cancer research.
PG  - 646-51
LID - 10.1038/nrc2913 [doi]
AB  - Cancer is caused by complex interactions between genes, environment and
      lifestyles. Biobanks of well-annotated human tissues are an important resource
      for studying the underlying mechanisms of cancer. Although such biobanks exist,
      their integration to form larger biobanks is now required to provide the
      diversity of samples that are needed to study the complexity and heterogeneity of
      cancer. Clear guidelines and policies are also required to address the challenges
      of integrating individual institutional or national biobanks and build public
      trust. This Science and Society article highlights some of the main practical and
      ethical issues that are undergoing discussion in the integration of tissue
      biobanks for cancer.
FAU - Watson, R William G
AU  - Watson RW
AD  - UCD School of Medicine and Medical Science, University College Dublin, Ireland.
      william.watson@ucd.ie
FAU - Kay, Elaine W
AU  - Kay EW
FAU - Smith, David
AU  - Smith D
LA  - eng
PT  - Review
DEP - 20100812
PL  - England
TA  - Nat Rev Cancer
JT  - Nature reviews. Cancer
JID - 101124168
SB  - IM
MH  - Animals
MH  - *Bioethical Issues
MH  - Biological Specimen Banks/*ethics/legislation & jurisprudence
MH  - *Ethics, Research
MH  - Guidelines as Topic
MH  - Humans
MH  - *Neoplasms
EDAT- 2010/08/13 06:00
MHDA- 2010/09/04 06:00
CRDT- 2010/08/13 06:00
PHST- 2010/08/13 06:00 [entrez]
PHST- 2010/08/13 06:00 [pubmed]
PHST- 2010/09/04 06:00 [medline]
AID - nrc2913 [pii]
AID - 10.1038/nrc2913 [doi]
PST - ppublish
SO  - Nat Rev Cancer. 2010 Sep;10(9):646-51. doi: 10.1038/nrc2913. Epub 2010 Aug 12.


PMID- 20703124
OWN - NLM
STAT- MEDLINE
DCOM- 20101208
LR  - 20220331
IS  - 1538-8646 (Electronic)
IS  - 0730-4625 (Linking)
VI  - 29
IP  - 5
DP  - 2010 Sep-Oct
TI  - Registered nurses and moral distress.
PG  - 197-202
LID - 10.1097/DCC.0b013e3181e6c344 [doi]
AB  - Nurses spend more time with patients at the end of life than any other member of 
      the health care team, giving them early insight into futility-of-care issues for 
      a particular patient. Providing futile care to dying patients is a well-known
      source of moral distress for nurses. Traditional ethical models are not always
      effective in dealing with these issues. The purpose of this article was to
      describe moral distress that is often experienced by nurses providing care to
      patients at the end of life and to propose the use of a model in dealing with
      associated ethical dilemmas in an effort to decrease the incidence of moral
      distress.
FAU - Robinson, Ruthie
AU  - Robinson R
AD  - Center for Nursing Innovation, CHRISTUS Hospital, 2830 Calder, Beaumont, TX
      77702, USA .rmresearch@hotmail.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Dimens Crit Care Nurs
JT  - Dimensions of critical care nursing : DCCN
JID - 8211489
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - Intensive Care Units
MH  - *Medical Futility
MH  - *Morals
MH  - Nursing Staff/*psychology
MH  - Stress, Psychological/*psychology
MH  - Terminally Ill
EDAT- 2010/08/13 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/13 06:00
PHST- 2010/08/13 06:00 [entrez]
PHST- 2010/08/13 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1097/DCC.0b013e3181e6c344 [doi]
AID - 00003465-201009000-00001 [pii]
PST - ppublish
SO  - Dimens Crit Care Nurs. 2010 Sep-Oct;29(5):197-202. doi:
      10.1097/DCC.0b013e3181e6c344.


PMID- 20702984
OWN - NLM
STAT- MEDLINE
DCOM- 20100930
LR  - 20190911
IS  - 0369-4305 (Print)
IS  - 0369-4305 (Linking)
VI  - 66
IP  - 6
DP  - 2010 Jun 20
TI  - [Ethics in clinical research].
PG  - 668-72
FAU - Ogasawara, Katsuhiko
AU  - Ogasawara K
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Nihon Hoshasen Gijutsu Gakkai Zasshi
JT  - Nihon Hoshasen Gijutsu Gakkai zasshi
JID - 7505722
SB  - IM
MH  - Authorship
MH  - Confidentiality/standards
MH  - Epidemiologic Studies
MH  - *Ethics, Research
MH  - Research Design
EDAT- 2010/08/13 06:00
MHDA- 2010/10/01 06:00
CRDT- 2010/08/13 06:00
PHST- 2010/08/13 06:00 [entrez]
PHST- 2010/08/13 06:00 [pubmed]
PHST- 2010/10/01 06:00 [medline]
AID - JST.JSTAGE/jjrt/66.668 [pii]
AID - 10.6009/jjrt.66.668 [doi]
PST - ppublish
SO  - Nihon Hoshasen Gijutsu Gakkai Zasshi. 2010 Jun 20;66(6):668-72. doi:
      10.6009/jjrt.66.668.


PMID- 20702593
OWN - NLM
STAT- MEDLINE
DCOM- 20110125
LR  - 20101015
IS  - 1096-0929 (Electronic)
IS  - 1096-0929 (Linking)
VI  - 118
IP  - 1
DP  - 2010 Nov
TI  - Transcriptomic profile indicative of immunotoxic exposure: in vitro studies in
      peripheral blood mononuclear cells.
PG  - 19-30
LID - 10.1093/toxsci/kfq239 [doi]
AB  - Investigating the immunotoxic effects of exposure to chemicals usually comprises 
      evaluation of weight and histopathology of lymphoid tissues, various lymphocyte
      parameters in the circulation, and immune function. Immunotoxicity assessment is 
      time consuming in humans or requires a high number of animals, making it
      expensive. Furthermore, reducing the use of animals in research is an important
      ethical and political issue. Immunotoxicogenomics represents a novel approach to 
      investigate immunotoxicity able of overcoming these limitations. The current
      research, embedded in the European Union project NewGeneris, aimed to retrieve
      gene expression profiles that are indicative of exposure to immunotoxicants. To
      this end, whole-genome gene expression was investigated in human peripheral blood
      mononuclear cells in response to in vitro exposure to a range of immunotoxic
      chemicals (4-hydroxy-2-nonenal, aflatoxin B1, benzo[a]pyrene, deoxynivalenol,
      ethanol, malondialdehyde, polychlorinated biphenyl 153, and
      2,3,7,8-tetrachlorodibenzo-p-dioxin) and nonimmunotoxic chemicals (acrylamide,
      dimethylnitrosamine, 2-amino-3-methyl-3H-imidazo[4,5-F]quinoline, and
      2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine). Using Agilent oligonucleotide
      microarrays, whole-genome gene expression profiles were generated, which were
      analyzed using Genedata's Expressionist software. Using Recursive Feature
      Elimination and Support Vector Machine, a set of 48 genes was identified that
      distinguishes the immunotoxic from the nonimmunotoxic compounds. Analysis for
      enrichment of biological processes showed the gene set to be highly biologically 
      and immunologically relevant. We conclude that we have identified a promising
      transcriptomic profile indicative of immunotoxic exposure.
FAU - Hochstenbach, Kevin
AU  - Hochstenbach K
AD  - Department of Health Risk Analysis and Toxicology, Maastricht University, 6200 MD
      Maastricht, The Netherlands.
FAU - van Leeuwen, Danitsja M
AU  - van Leeuwen DM
FAU - Gmuender, Hans
AU  - Gmuender H
FAU - Stolevik, Solvor B
AU  - Stolevik SB
FAU - Nygaard, Unni C
AU  - Nygaard UC
FAU - Lovik, Martinus
AU  - Lovik M
FAU - Granum, Berit
AU  - Granum B
FAU - Namork, Ellen
AU  - Namork E
FAU - van Delft, Joost H M
AU  - van Delft JH
FAU - van Loveren, Henk
AU  - van Loveren H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100811
PL  - United States
TA  - Toxicol Sci
JT  - Toxicological sciences : an official journal of the Society of Toxicology
JID - 9805461
RN  - 0 (Immunologic Factors)
RN  - 0 (Xenobiotics)
SB  - IM
MH  - Adult
MH  - Cell Proliferation/drug effects
MH  - Cell Survival/drug effects
MH  - Cells, Cultured
MH  - Female
MH  - Gene Expression Profiling
MH  - Gene Expression Regulation/*drug effects/immunology
MH  - Humans
MH  - Immunologic Factors/classification/immunology/*toxicity
MH  - Leukocytes, Mononuclear/*drug effects/immunology/metabolism
MH  - Male
MH  - Oligonucleotide Array Sequence Analysis
MH  - Xenobiotics/classification/immunology/*toxicity
EDAT- 2010/08/13 06:00
MHDA- 2011/01/28 06:00
CRDT- 2010/08/13 06:00
PHST- 2010/08/13 06:00 [entrez]
PHST- 2010/08/13 06:00 [pubmed]
PHST- 2011/01/28 06:00 [medline]
AID - kfq239 [pii]
AID - 10.1093/toxsci/kfq239 [doi]
PST - ppublish
SO  - Toxicol Sci. 2010 Nov;118(1):19-30. doi: 10.1093/toxsci/kfq239. Epub 2010 Aug 11.


PMID- 20702441
OWN - NLM
STAT- MEDLINE
DCOM- 20110204
LR  - 20211020
IS  - 1475-3901 (Electronic)
IS  - 1475-3898 (Linking)
VI  - 19
IP  - 5
DP  - 2010 Oct
TI  - Departures from the protocol during conduct of a clinical trial: a pattern from
      the data record consistent with a learning curve.
PG  - 405-10
LID - 10.1136/qshc.2008.028605 [doi]
AB  - OBJECTIVE: Recognition of learning curves in medical skill acquisition has
      enhanced patient safety through improved training techniques. Clinical trials
      research has not been similarly scrutinised. The VALsartan In Acute myocardial
      iNfarcTion, a large multinational, pragmatic, randomised, double-blind,
      multicentre trial, was retrospectively evaluated for evidence of research conduct
      consistent with a performance "learning curve". DESIGN: Records provided protocol
      departure (deviations/violations) and documentation query data. For each site,
      analysis included patient order (eg, first, second), recruitment rate and first
      enrollment relative to study start date. SETTING: Computerised data from a trial 
      coordinated by an academic research organisation collaborating with 10 academic
      and 2 commercial research organisations and an industry sponsor. Interventions
      931 sites enrolled 14,703 patients. Departures were restricted to the first year.
      Exclusions included patient's death or loss to follow-up within 12 months and
      subjects enrolled 80th or higher at a site. Departures were assessed for variance
      with higher patient rank, more frequent recruitment and later start date. METHODS
      AND RESULTS: 12,367 patients at 931 sites were analysed. Departures were more
      common for patients enrolled earlier at a site (p<0.0001). For example, compared 
      with the 30th patient, the first had 47% more departures. Departures were also
      more common with slower enrollment and site start closer to the trial start date 
      (p<0.0001). Similar patterns existed for queries. CONCLUSIONS: Research
      performance improved during the VALsartan In Acute myocardial iNfarcTion
      consistent with a "learning curve". Although effects were not related to a change
      in outcome (mortality), learning curves in clinical research may have important
      safety, ethical, research quality and economic implications for trial conduct.
FAU - Taekman, J M
AU  - Taekman JM
AD  - Department of Anesthesiology, Duke University Medical Center, Box 3094, Durham,
      NC 27710, USA. jeffrey.taekman@duke.edu
FAU - Stafford-Smith, M
AU  - Stafford-Smith M
FAU - Velazquez, E J
AU  - Velazquez EJ
FAU - Wright, M C
AU  - Wright MC
FAU - Phillips-Bute, B G
AU  - Phillips-Bute BG
FAU - Pfeffer, M A
AU  - Pfeffer MA
FAU - Sellers, M A
AU  - Sellers MA
FAU - Pieper, K S
AU  - Pieper KS
FAU - Newman, M F
AU  - Newman MF
FAU - Van de Werf, F
AU  - Van de Werf F
FAU - Diaz, R
AU  - Diaz R
FAU - Leimberger, J
AU  - Leimberger J
FAU - Califf, R M
AU  - Califf RM
LA  - eng
GR  - R01 NS049548/NS/NINDS NIH HHS/United States
GR  - R01 NS049548-01/NS/NINDS NIH HHS/United States
GR  - #1R01NS49548-01/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20100810
PL  - England
TA  - Qual Saf Health Care
JT  - Quality & safety in health care
JID - 101136980
MH  - *Clinical Protocols
MH  - *Guideline Adherence
MH  - Humans
MH  - *Learning Curve
MH  - Multicenter Studies as Topic
MH  - *Randomized Controlled Trials as Topic
MH  - Retrospective Studies
PMC - PMC3258507
MID - NIHMS336104
EDAT- 2010/08/13 06:00
MHDA- 2011/02/05 06:00
CRDT- 2010/08/13 06:00
PHST- 2010/08/13 06:00 [entrez]
PHST- 2010/08/13 06:00 [pubmed]
PHST- 2011/02/05 06:00 [medline]
AID - qshc.2008.028605 [pii]
AID - 10.1136/qshc.2008.028605 [doi]
PST - ppublish
SO  - Qual Saf Health Care. 2010 Oct;19(5):405-10. doi: 10.1136/qshc.2008.028605. Epub 
      2010 Aug 10.


PMID- 20702389
OWN - NLM
STAT- MEDLINE
DCOM- 20101210
LR  - 20110801
IS  - 1468-2044 (Electronic)
IS  - 0003-9888 (Linking)
VI  - 95
IP  - 11
DP  - 2010 Nov
TI  - Lest we forget... research ethics in children: perhaps onerous, yet absolutely
      necessary.
PG  - 863-6
LID - 10.1136/adc.2009.179762 [doi]
FAU - Brierley, Joe
AU  - Brierley J
AD  - Paediatric and Neonatal Intensive Care Unit, Great Ormond Street Hospital for
      Children, London, UK. brierj@gosh.nhs.uk
FAU - Larcher, Vic
AU  - Larcher V
LA  - eng
PT  - Historical Article
PT  - Journal Article
DEP - 20100810
PL  - England
TA  - Arch Dis Child
JT  - Archives of disease in childhood
JID - 0372434
SB  - IM
CIN - Arch Dis Child. 2011 Jul;96(7):699. PMID: 21285228
MH  - Child
MH  - Codes of Ethics
MH  - *Ethics, Research/history
MH  - History, 19th Century
MH  - History, 20th Century
MH  - Humans
MH  - Pediatrics/*ethics/history
EDAT- 2010/08/13 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/13 06:00
PHST- 2010/08/13 06:00 [entrez]
PHST- 2010/08/13 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - adc.2009.179762 [pii]
AID - 10.1136/adc.2009.179762 [doi]
PST - ppublish
SO  - Arch Dis Child. 2010 Nov;95(11):863-6. doi: 10.1136/adc.2009.179762. Epub 2010
      Aug 10.


PMID- 20701222
OWN - NLM
STAT- MEDLINE
DCOM- 20101122
LR  - 20100812
IS  - 1120-9135 (Print)
IS  - 1120-9135 (Linking)
VI  - 22
IP  - 1 Suppl 1
DP  - 2010 Jan-Feb
TI  - [Ethical decalogue of Vincenzo Cuomo].
PG  - 17-9
FAU - De Gregorio, Vincenzo
AU  - De Gregorio V
AD  - Conservatorio di Musica di San Pietro a Majella, Napoli.
      direzioneamministrativa@sanpietroamajella.it
LA  - ita
PT  - Biography
PT  - Historical Article
PT  - Journal Article
TT  - Il decalogo etico di Vincenzo Cuomo.
PL  - Italy
TA  - Ann Ig
JT  - Annali di igiene : medicina preventiva e di comunita
JID - 9002865
SB  - IM
MH  - Clinical Medicine/history
MH  - Ethics
MH  - History, 19th Century
MH  - History, 20th Century
MH  - Italy
PS  - Cuomo V
FPS - Cuomo, Vincenzo
EDAT- 2010/08/13 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/13 06:00
PHST- 2010/08/13 06:00 [entrez]
PHST- 2010/08/13 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - Ann Ig. 2010 Jan-Feb;22(1 Suppl 1):17-9.


PMID- 20701187
OWN - NLM
STAT- MEDLINE
DCOM- 20100903
LR  - 20100812
IS  - 1462-2815 (Print)
IS  - 1462-2815 (Linking)
VI  - 83
IP  - 7
DP  - 2010 Jul
TI  - The joys and challenges of semi-structured interviewing.
PG  - 18-21
AB  - Semi-structured interviewing is an important tool for gathering data in
      qualitative research. This paper explores some of the joys and challenges
      associated with research interviewing. It discusses some of the basic skills
      required to do interviewing well, some of the difficulties associated with
      interviewing on a practical and emotional level, and how to address them. Being a
      good interviewer in a research context means to be aware of the responsibility
      for the participants' wellbeing as well as one's own. Good listening skills and
      emotional control are among the most crucial skills to develop. This paper
      summarises some of the skills needed to remain or become a professional,
      empathetic and ethical interviewer in the context of community practice. If some 
      basic guidelines are followed and combined with practice, the craft of
      interviewing can become an art.
FAU - Adams, Eike
AU  - Adams E
AD  - School of Health and Social Care, Oxford Brookes University.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Community Pract
JT  - Community practitioner : the journal of the Community Practitioners' & Health
      Visitors' Association
JID - 9809060
MH  - Communication
MH  - Empathy
MH  - Humans
MH  - Interviews as Topic/*methods
MH  - Nurse's Role/psychology
MH  - Nursing Methodology Research/ethics/*methods
MH  - Practice Guidelines as Topic
MH  - Professional Competence
MH  - *Qualitative Research
MH  - Researcher-Subject Relations/ethics/psychology
EDAT- 2010/08/13 06:00
MHDA- 2010/09/04 06:00
CRDT- 2010/08/13 06:00
PHST- 2010/08/13 06:00 [entrez]
PHST- 2010/08/13 06:00 [pubmed]
PHST- 2010/09/04 06:00 [medline]
PST - ppublish
SO  - Community Pract. 2010 Jul;83(7):18-21.


PMID- 20701171
OWN - NLM
STAT- MEDLINE
DCOM- 20100916
LR  - 20100812
IS  - 1932-149X (Print)
IS  - 1932-149X (Linking)
VI  - 5
IP  - 3
DP  - 2010 May-Jun
TI  - Healthcare ethics: the experience after the Haitian earthquake.
PG  - 141-7
AB  - On January 12, 2010, a 7.0 Richter earthquake devastated Haiti and its public
      health infrastructure leading to a worldwide humanitarian effort. The United
      States sent forces to Haiti's assistance including the USNS Comfort, a tertiary
      care medical center on board a ship. Besides setting a transparent triage and
      medical regulating system, the leadership on the Comfort instituted a
      multidisciplinary Healthcare Ethics Committee to assist in delivering the highest
      level efficient care to the largest number of victims. Allocation of resources
      was based on time-honored ethics principles, the concept of mass casualty triage 
      in the setting of resource constraints, and constructs developed by the host
      nation's Ministry of Health. In offering aid in austere circumstances, healthcare
      practitioners must not only adhere to the basic healthcare ethics principles but 
      also practice respect for communities, cultures, and traditions, as well as
      demonstrate respect for the sovereignty of the host nation. The principles
      outlined herein should serve as guidance for future disaster relief missions.
      This work is in accordance with BUMEDINST 6010.25, Establishment of Healthcare
      Ethics Committees.
FAU - Etienne, Mill
AU  - Etienne M
AD  - Department of Neurology, National Naval Medical Center, Bethesda, Maryland, USA.
FAU - Powell, Clydette
AU  - Powell C
FAU - Amundson, Dennis
AU  - Amundson D
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Disaster Med
JT  - American journal of disaster medicine
JID - 101291100
SB  - IM
MH  - *Earthquakes
MH  - Ethics Committees/*organization & administration
MH  - Haiti
MH  - Health Resources
MH  - Hospitals, Military
MH  - Humans
MH  - Naval Medicine
MH  - Rescue Work/*ethics
MH  - *Ships
MH  - Triage/ethics
MH  - United States
EDAT- 2010/08/13 06:00
MHDA- 2010/09/18 06:00
CRDT- 2010/08/13 06:00
PHST- 2010/08/13 06:00 [entrez]
PHST- 2010/08/13 06:00 [pubmed]
PHST- 2010/09/18 06:00 [medline]
PST - ppublish
SO  - Am J Disaster Med. 2010 May-Jun;5(3):141-7.


PMID- 20701015
OWN - NLM
STAT- MEDLINE
DCOM- 20100929
LR  - 20100812
IS  - 1660-9379 (Print)
IS  - 1660-9379 (Linking)
VI  - 6
IP  - 256
DP  - 2010 Jul 14
TI  - [The example of cystic fibrosis to highlight the complexity of genetic
      screening].
PG  - 1395-9
AB  - Various institutions and countries often reach different conclusions about the
      utility of introducing a newborn screening test in the general population. This
      paper highlights the complexity of population screening including genetic tests. 
      Using the example of cystic fibrosis genetic screening, for which a Swiss Working
      Group for Cystic Fibrosis is currently evaluating the pertinence, we outline that
      screening recommendations are often based more on expert opinion and emerging new
      technologies rather than on evidence. We also present some ethical and economic
      issues related to cystic fibrosis genetic screening.
FAU - Bochud, Murielle
AU  - Bochud M
AD  - Unite de prevention communautaire, IUMSP, CHUV, Lausanne. Murielle.Bochud@chuv.ch
FAU - Fellmann, Florence
AU  - Fellmann F
FAU - Vader, John-Paul
AU  - Vader JP
FAU - Grosse, Scott
AU  - Grosse S
FAU - Paccaud, Fred
AU  - Paccaud F
FAU - Guessous, Idris
AU  - Guessous I
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Mucoviscidose: illustration de la complexite du depistage genetique.
PL  - Switzerland
TA  - Rev Med Suisse
JT  - Revue medicale suisse
JID - 101219148
RN  - 0 (CFTR protein, human)
RN  - 126880-72-6 (Cystic Fibrosis Transmembrane Conductance Regulator)
SB  - IM
MH  - Cystic Fibrosis/*genetics
MH  - Cystic Fibrosis Transmembrane Conductance Regulator/genetics
MH  - *Genetic Testing
MH  - Humans
MH  - Mutation
EDAT- 2010/08/13 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/08/13 06:00
PHST- 2010/08/13 06:00 [entrez]
PHST- 2010/08/13 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
PST - ppublish
SO  - Rev Med Suisse. 2010 Jul 14;6(256):1395-9.


PMID- 20675945
OWN - NLM
STAT- MEDLINE
DCOM- 20100913
LR  - 20100802
IS  - 1548-6869 (Electronic)
IS  - 1049-2089 (Linking)
VI  - 21
IP  - 3 Suppl
DP  - 2010 Aug
TI  - A foundation for public health ethics at Tuskegee University in the 21st century.
PG  - 46-56
LID - 10.1353/hpu.0.0358 [doi]
AB  - This commentary is a reflection on Tuskegee University's National Center for
      Bioethics in Research and Health Care on the health and ethical challenges of the
      21st century. The Center has dedicated the last 10 years to addressing the
      unresolved biomedicine and public health issues and/or the ethical dilemmas that 
      plague the nation's health. The authors believe that health disparities continue 
      to worsen because the approach under-appreciates the ethical dilemma that plagues
      health policy and health disparities. The authors discuss synergies and the
      paradigmatic differences between science and medicine, religion, spirituality,
      and faith. They also discuss the importance of considering these relationships if
      improvements in the health of people of African descent are expected. The concept
      of Optimal Health is explored.
FAU - Warren, Rueben C
AU  - Warren RC
AD  - National Center for Bioethics in Research and Health Care, Tuskegee, AL, USA.
FAU - Tarver, Will L
AU  - Tarver WL
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - J Health Care Poor Underserved
JT  - Journal of health care for the poor and underserved
JID - 9103800
SB  - IM
MH  - African Americans
MH  - Alabama
MH  - Bioethics/*trends
MH  - Health Status Disparities
MH  - History, 21st Century
MH  - Humans
MH  - Public Health/*ethics
MH  - Religion and Medicine
MH  - Universities/*organization & administration
EDAT- 2010/08/13 06:00
MHDA- 2010/09/14 06:00
CRDT- 2010/08/03 06:00
PHST- 2010/08/03 06:00 [entrez]
PHST- 2010/08/13 06:00 [pubmed]
PHST- 2010/09/14 06:00 [medline]
AID - S1548686910300064 [pii]
AID - 10.1353/hpu.0.0358 [doi]
PST - ppublish
SO  - J Health Care Poor Underserved. 2010 Aug;21(3 Suppl):46-56. doi:
      10.1353/hpu.0.0358.


PMID- 20675944
OWN - NLM
STAT- MEDLINE
DCOM- 20100913
LR  - 20211020
IS  - 1548-6869 (Electronic)
IS  - 1049-2089 (Linking)
VI  - 21
IP  - 3 Suppl
DP  - 2010 Aug
TI  - The ethics of good communication in a complex research partnership.
PG  - 35-45
LID - 10.1353/hpu.0.0356 [doi]
AB  - The tripartite partnership among Morehouse School of Medicine, Tuskegee
      University, and University of Alabama at Birmingham is complex. In 2005, the
      three schools--with different institutional cultures, characters, and
      resources--agreed to collaborate in efforts to eliminate racial/ethnic
      disparities in cancer burdens. Pursuing this laudable aim predictably involved
      some miscommunication. The Bioethics Shared Resource (BSR) group foresaw such
      challenges and monitored interactions to prevent harm, noting that while
      effective communication is critical to the achievement of mutual goals, an
      understanding and prudent use of proven communication principles is a sine qua
      non for success. In this commentary, we share the undergirding moral concepts,
      communication approaches, and lessons learned. This experience has led us to
      propose an ethics of good communication for others to consider.
FAU - Sodeke, Stephen
AU  - Sodeke S
AD  - National Center for Bioethics in Research and Health Care, Tuskegee University,
      Tuskegee, AL 36088, USA. sodeke@tuskegee.edu
FAU - Turner, Timothy
AU  - Turner T
FAU - Tarver, Will
AU  - Tarver W
LA  - eng
GR  - G12 MD007585/MD/NIMHD NIH HHS/United States
GR  - U54 CA118623/CA/NCI NIH HHS/United States
GR  - U54 CA118948/CA/NCI NIH HHS/United States
GR  - P76/CCP424229/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Health Care Poor Underserved
JT  - Journal of health care for the poor and underserved
JID - 9103800
SB  - IM
MH  - Alabama
MH  - *Communication
MH  - *Cooperative Behavior
MH  - *Ethics, Research
MH  - Health Status Disparities
MH  - Humans
MH  - *Interinstitutional Relations
MH  - Morals
MH  - Neoplasms/ethnology/prevention & control
MH  - Schools, Medical
MH  - Universities
PMC - PMC3754437
MID - NIHMS495647
EDAT- 2010/08/13 06:00
MHDA- 2010/09/14 06:00
CRDT- 2010/08/03 06:00
PHST- 2010/08/03 06:00 [entrez]
PHST- 2010/08/13 06:00 [pubmed]
PHST- 2010/09/14 06:00 [medline]
AID - S1548686910300052 [pii]
AID - 10.1353/hpu.0.0356 [doi]
PST - ppublish
SO  - J Health Care Poor Underserved. 2010 Aug;21(3 Suppl):35-45. doi:
      10.1353/hpu.0.0356.


PMID- 20675942
OWN - NLM
STAT- MEDLINE
DCOM- 20100913
LR  - 20100802
IS  - 1548-6869 (Electronic)
IS  - 1049-2089 (Linking)
VI  - 21
IP  - 3 Suppl
DP  - 2010 Aug
TI  - Tuskegee Bioethics Center 10th anniversary presentation: "Commemorating 10 years:
      ethical perspectives on origin and destiny".
PG  - 21-5
LID - 10.1353/hpu.0.0352 [doi]
AB  - More than 70 years have passed since the beginning of the Public Health Service
      syphilis study in Tuskegee, Alabama, and it has been over a decade since
      President Bill Clinton formally apologized for it and held a ceremony for the
      Tuskegee study participants. The official launching of the Tuskegee University
      National Center for Bioethics in Research and Health Care took place two years
      after President Clinton's apology. How might we fittingly discuss the Center's
      10th Anniversary and the topic 'Commemorating 10 Years: Ethical Perspectives on
      Origin and Destiny'? Over a decade ago, a series of writers, many of them African
      Americans, wrote a text entitled 'African-American Perspectives on Biomedical
      Ethics'; their text was partly responsible for a prolonged reflection by others
      to produce a subsequent work, 'African American Bioethics: Culture, Race and
      Identity'. What is the relationship between the discipline of bioethics and
      African American culture? This and related questions are explored in this
      commentary.
FAU - Prograis, Lawrence J Jr
AU  - Prograis LJ Jr
AD  - Center for Clinical Bioethics, Georgetown University, Washington, DC 20057-1409, 
      USA.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - J Health Care Poor Underserved
JT  - Journal of health care for the poor and underserved
JID - 9103800
SB  - IM
MH  - African Americans/history
MH  - Alabama
MH  - Bioethics/*trends
MH  - Culture
MH  - Ethics, Research/*history
MH  - Financing, Government/history
MH  - History, 20th Century
MH  - Humans
MH  - Syphilis/ethnology/history
MH  - Universities/*history/organization & administration
EDAT- 2010/08/13 06:00
MHDA- 2010/09/14 06:00
CRDT- 2010/08/03 06:00
PHST- 2010/08/03 06:00 [entrez]
PHST- 2010/08/13 06:00 [pubmed]
PHST- 2010/09/14 06:00 [medline]
AID - S1548686910300039 [pii]
AID - 10.1353/hpu.0.0352 [doi]
PST - ppublish
SO  - J Health Care Poor Underserved. 2010 Aug;21(3 Suppl):21-5. doi:
      10.1353/hpu.0.0352.


PMID- 20675941
OWN - NLM
STAT- MEDLINE
DCOM- 20100913
LR  - 20100802
IS  - 1548-6869 (Electronic)
IS  - 1049-2089 (Linking)
VI  - 21
IP  - 3 Suppl
DP  - 2010 Aug
TI  - Sankofan socio-ethical reflections: the Tuskegee University National Bioethics
      Center's decade of operation, 1999-2009.
PG  - 6-20
LID - 10.1353/hpu.0.0365 [doi]
AB  - Primarily, this is a Sankofan socio-ethical analysis of the moral foundation of
      the Tuskegee University National Bioethics Center's decade of operation. The
      first section of the study will do the following: a) a Sankofan socio-ethical
      analysis of the Center's raison d'etre; and b) definitions of ethical terms and
      the social world of the infamous syphilis study. The second section, as a result 
      of the analysis, will address the Center's following challenges: c) the Center's 
      challenge of theory and practice; d) the Center's challenge of moral heritage;
      and e) the Center's challenge of the future.
FAU - Earl, Riggins R Jr
AU  - Earl RR Jr
AD  - Interdenominational Theological Seminary, 1409 Martin Luther King, Jr. Drive SW, 
      Atlanta, GA 30314, USA. dukeearl@bellsouth.net
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - J Health Care Poor Underserved
JT  - Journal of health care for the poor and underserved
JID - 9103800
SB  - IM
MH  - African Americans/history
MH  - Alabama
MH  - Bioethics/*history
MH  - *Ethical Analysis
MH  - Ethical Theory
MH  - Ethics, Research/*history
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Morals
MH  - Syphilis/ethnology/history
MH  - Terminology as Topic
MH  - Universities/*history/organization & administration
EDAT- 2010/08/13 06:00
MHDA- 2010/09/14 06:00
CRDT- 2010/08/03 06:00
PHST- 2010/08/03 06:00 [entrez]
PHST- 2010/08/13 06:00 [pubmed]
PHST- 2010/09/14 06:00 [medline]
AID - S1548686910300027 [pii]
AID - 10.1353/hpu.0.0365 [doi]
PST - ppublish
SO  - J Health Care Poor Underserved. 2010 Aug;21(3 Suppl):6-20. doi:
      10.1353/hpu.0.0365.


PMID- 20700948
OWN - NLM
STAT- MEDLINE
DCOM- 20110128
LR  - 20191027
IS  - 1532-2653 (Electronic)
IS  - 0967-5868 (Linking)
VI  - 17
IP  - 9
DP  - 2010 Sep
TI  - Ethical considerations for normal control subjects in MRI research.
PG  - 1111-3
AB  - MRI is increasingly used as a research tool with the inclusion of "normal"
      control subjects, raising ethical issues when significant incidental
      abnormalities are found on research MRIs. We report two asymptomatic young men
      who had lesions discovered on MRIs performed for research in which they were
      acting as normal controls. We discuss the ethical considerations raised by these 
      patients in imaging research, including appropriate subject selection, study
      design to include protocol mechanisms for incidental findings, informed consent
      and the need for expert clinical review of images.
FAU - Chow, Andrew
AU  - Chow A
AD  - Department of Neurosurgery, Royal Melbourne Hospital, Parkville, Victoria,
      Australia. andrewjchow@gmail.com
FAU - Drummond, Katharine J
AU  - Drummond KJ
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Scotland
TA  - J Clin Neurosci
JT  - Journal of clinical neuroscience : official journal of the Neurosurgical Society 
      of Australasia
JID - 9433352
SB  - IM
MH  - Adult
MH  - Biomedical Research/*ethics
MH  - Brain Neoplasms/*diagnosis/surgery
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Magnetic Resonance Imaging/*ethics
MH  - Male
MH  - Young Adult
EDAT- 2010/08/12 06:00
MHDA- 2011/02/01 06:00
CRDT- 2010/08/12 06:00
PHST- 2010/08/12 06:00 [entrez]
PHST- 2010/08/12 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
AID - 10.1016/j.jocn.2010.02.004 [doi]
PST - ppublish
SO  - J Clin Neurosci. 2010 Sep;17(9):1111-3. doi: 10.1016/j.jocn.2010.02.004.


PMID- 20700786
OWN - NLM
STAT- MEDLINE
DCOM- 20110114
LR  - 20181201
IS  - 1437-1588 (Electronic)
IS  - 1436-9990 (Linking)
VI  - 53
IP  - 8
DP  - 2010 Aug
TI  - [Pharmacological neuroenhancement and brain doping : Chances and risks].
PG  - 853-9
LID - 10.1007/s00103-010-1105-0 [doi]
AB  - Pharmacological neuroenhancement refers to the use of psychoactive substances by 
      healthy subjects with the purpose of cognitive enhancement, e.g., vigilance,
      concentration, memory, or mood. "Brain doping", however, refers to the illicit
      use of a subcategory of these substances such as prescription drugs. This
      subcategory includes psychostimulants (e.g., amphetamines, methylphenidate),
      modafinil, antidementia drugs (acetylcholine-esterase inhibitors, memantine), and
      antidepressants (selective serotonin reuptake inhibitors) which are being
      prescribed for the treatment of ADHD (attention deficit/hyperactivity disorder), 
      Alzheimer's disease, and depression. Only psychostimulants and modafinil show
      significant effects on concentration, attentiveness, and vigilance in healthy
      subjects. However, a general use by healthy persons can not be justified because 
      of relevant side effects and safety risks. Caffeine for pharmacological
      neuroenhancement can be seen as an equally effective alternative. "Brain doping" 
      raises numerous ethical and social concerns that require a continued discussion. 
      Demands of liberalization should be critically questioned.
FAU - Franke, A G
AU  - Franke AG
AD  - Klinik fur Psychiatrie und Psychotherapie, Universitatsmedizin der Johannes
      Gutenberg-Universitat, Mainz, Deutschland. afranke@uni-mainz.de
FAU - Lieb, K
AU  - Lieb K
LA  - ger
PT  - Journal Article
PT  - Review
TT  - Pharmakologisches Neuroenhancement und "Hirndoping" : Chancen und Risiken.
PL  - Germany
TA  - Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
JT  - Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
JID - 101181368
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Psychotropic Drugs)
RN  - R3UK8X3U3D (Modafinil)
SB  - IM
MH  - Benzhydryl Compounds/adverse effects
MH  - Brain/*drug effects
MH  - Central Nervous System Stimulants/adverse effects
MH  - Cross-Sectional Studies
MH  - Dose-Response Relationship, Drug
MH  - Germany
MH  - Humans
MH  - Mental Processes/*drug effects
MH  - Modafinil
MH  - *Psychotropic Drugs/adverse effects
MH  - Randomized Controlled Trials as Topic
MH  - Substance-Related Disorders/epidemiology/*psychology
EDAT- 2010/08/12 06:00
MHDA- 2011/01/15 06:00
CRDT- 2010/08/12 06:00
PHST- 2010/08/12 06:00 [entrez]
PHST- 2010/08/12 06:00 [pubmed]
PHST- 2011/01/15 06:00 [medline]
AID - 10.1007/s00103-010-1105-0 [doi]
PST - ppublish
SO  - Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2010
      Aug;53(8):853-9. doi: 10.1007/s00103-010-1105-0.


PMID- 20700554
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20191111
IS  - 2172-6825 (Electronic)
IS  - 0873-2159 (Linking)
VI  - 16
IP  - 4
DP  - 2010 Jul-Aug
TI  - The health-related quality of life of patients with chronic obstructive pulmonary
      disease and asthma evaluated by the SGRQ.
PG  - 543-58
AB  - AIMS: To compare the effects of asthma and chronic obstructive pulmonary disease 
      (COPD) on the quality of life of patients evaluated using the Saint George
      Respiratory Questionnaire (SGRQ) through correlating the variables, domains and
      total score. METHODS: A cross-sectional study from October 2008 to March 2009
      with 75 adult outpatients at the University Hospital of Salamanca, Spain.
      Patients provided their clinical and socio-demographical data after being
      informed of the study's aims and ethical aspects. The Spanish version of the SGRQ
      and the statistical packa ge Statistics SPSS version 17.0 were used for
      statistical analysis. RESULTS: 65.3% were male and 34.7% female with mean age
      60.4 years. 68% had a diagnosis of asthma and 30.7% COPD. Statistically
      significant differences (p<0.05) between diagnosis and the 'activity' domain were
      found. None were found between gender, smoking, ex-smoking or hypertension and
      the domains. The income levels were inversely related (p=0.038) with the total
      score. Statistically significant differences between age and the 'activity'
      (p<0.01) and 'impact' (p<0.05) domains and the SGRQ total score were found
      (p<0.01). The forced expiratory volume in one second (FEV1%pred) only correlated 
      with the 'activity' domain (p<0.01) and with the total score (p<0.01).
      CONCLUSIONS: No variable correlated with all domains and the total score of the
      instrument. Some presented no statistically significant difference.
FAU - Maria S Pinto, Juliana
AU  - Maria S Pinto J
AD  - Doutoramento em Avances en Investigacion sobre Discapacidad, Universidade de
      Salamanca, Bolseista, Espanha. jujumsp@yahoo.com.br
FAU - Ramos Gonzalez, Jacinto
AU  - Ramos Gonzalez J
FAU - Ignacio C Arenillas, Jose
AU  - Ignacio C Arenillas J
FAU - Maria M Nogueras, Ana
AU  - Maria M Nogueras A
FAU - Pedro G Gomez, Francisco
AU  - Pedro G Gomez F
LA  - eng
LA  - por
PT  - Comparative Study
PT  - Journal Article
PL  - Spain
TA  - Rev Port Pneumol
JT  - Revista portuguesa de pneumologia
JID - 9813736
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Asthma/diagnosis
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Pulmonary Disease, Chronic Obstructive/diagnosis
MH  - *Quality of Life
MH  - *Surveys and Questionnaires
MH  - Young Adult
EDAT- 2010/08/12 06:00
MHDA- 2011/01/07 06:00
CRDT- 2010/08/12 06:00
PHST- 2010/08/12 06:00 [entrez]
PHST- 2010/08/12 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
AID - S0873-2159(15)30051-9 [pii]
AID - 10.1016/s2173-5115(10)70058-0 [doi]
PST - ppublish
SO  - Rev Port Pneumol. 2010 Jul-Aug;16(4):543-58. doi: 10.1016/s2173-5115(10)70058-0.


PMID- 20700372
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 0138-9130 (Print)
IS  - 0138-9130 (Linking)
VI  - 84
IP  - 3
DP  - 2010 Sep
TI  - Harmonic publication and citation counting: sharing authorship credit equitably -
      not equally, geometrically or arithmetically.
PG  - 785-793
AB  - Bibliometric counting methods need to be validated against perceived notions of
      authorship credit allocation, and standardized by rejecting methods with poor fit
      or questionable ethical implications. Harmonic counting meets these concerns by
      exhibiting a robust fit to previously published empirical data from medicine,
      psychology and chemistry, and by complying with three basic ethical criteria for 
      the equitable sharing of authorship credit. Harmonic counting can also
      incorporate additional byline information about equal contribution, or the
      elevated status of a corresponding last author. By contrast, several previously
      proposed counting schemes from the bibliometric literature including arithmetic, 
      geometric and fractional counting, do not fit the empirical data as well and do
      not consistently meet the ethical criteria. In conclusion, harmonic counting
      would seem to provide unrivalled accuracy, fairness and flexibility to the long
      overdue task of standardizing bibliometric allocation of publication and citation
      credit.
FAU - Hagen, Nils T
AU  - Hagen NT
AD  - Faculty of Biosciences and Aquaculture, Bodo University College, Bodo, Norway.
LA  - eng
PT  - Journal Article
DEP - 20091216
PL  - Netherlands
TA  - Scientometrics
JT  - Scientometrics
JID - 7901197
PMC - PMC2909428
EDAT- 2010/08/12 06:00
MHDA- 2010/08/12 06:01
CRDT- 2010/08/12 06:00
PHST- 2009/09/28 00:00 [received]
PHST- 2010/08/12 06:00 [entrez]
PHST- 2010/08/12 06:00 [pubmed]
PHST- 2010/08/12 06:01 [medline]
AID - 10.1007/s11192-009-0129-4 [doi]
PST - ppublish
SO  - Scientometrics. 2010 Sep;84(3):785-793. doi: 10.1007/s11192-009-0129-4. Epub 2009
      Dec 16.


PMID- 20700090
OWN - NLM
STAT- MEDLINE
DCOM- 20101005
LR  - 20220325
IS  - 1530-6550 (Print)
IS  - 1530-6550 (Linking)
VI  - 11
IP  - 2
DP  - 2010 Spring
TI  - Recognition of noncardiac findings on cardiac computed tomography examination.
PG  - 84-91
LID - 10.3909/ricm0521 [doi]
AB  - Multislice computed tomography (CT) is rapidly emerging as a novel technique for 
      the evaluation of coronary artery disease. It is anticipated that with increasing
      acceptance of this imaging technique, CT for calcium scores and CT angiography
      will be performed in ever greater numbers. Thus, it is all but inevitable that
      clinicians will stumble upon incidental findings given the sheer number of vital 
      organs and blood vessels that are imaged in the field of view. This article
      reviews the literature on incidental findings on cardiac CT with a focus on
      pulmonary nodules, ethical aspects of following up such findings, and cost
      implications.
FAU - George, Anil
AU  - George A
AD  - Cardiovascular Sciences Department, Brody School of Medicine, Greenville, NC,
      USA.
FAU - Movahed, Assad
AU  - Movahed A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Singapore
TA  - Rev Cardiovasc Med
JT  - Reviews in cardiovascular medicine
JID - 100960007
SB  - IM
MH  - Chest Pain/diagnostic imaging
MH  - Coronary Angiography/economics/ethics/*methods
MH  - Health Care Costs
MH  - Heart Diseases/*diagnostic imaging
MH  - Humans
MH  - *Incidental Findings
MH  - Lung Neoplasms/diagnostic imaging
MH  - Practice Guidelines as Topic
MH  - Predictive Value of Tests
MH  - Pulmonary Embolism/diagnostic imaging
MH  - Solitary Pulmonary Nodule/diagnostic imaging
MH  - *Tomography, X-Ray Computed/economics/ethics
RF  - 46
EDAT- 2010/08/12 06:00
MHDA- 2010/10/06 06:00
CRDT- 2010/08/12 06:00
PHST- 2010/08/12 06:00 [entrez]
PHST- 2010/08/12 06:00 [pubmed]
PHST- 2010/10/06 06:00 [medline]
AID - 10.3909/ricm0521 [doi]
PST - ppublish
SO  - Rev Cardiovasc Med. 2010 Spring;11(2):84-91. doi: 10.3909/ricm0521.


PMID- 20699450
OWN - NLM
STAT- MEDLINE
DCOM- 20100812
LR  - 20191210
IS  - 1538-3598 (Electronic)
IS  - 0098-7484 (Linking)
VI  - 304
IP  - 6
DP  - 2010 Aug 11
TI  - IOM advises FDA on ethics in postmarket safety trials.
PG  - 627
LID - 10.1001/jama.2010.1080 [doi]
FAU - Kuehn, Bridget M
AU  - Kuehn BM
LA  - eng
PT  - News
PL  - United States
TA  - JAMA
JT  - JAMA
JID - 7501160
SB  - IM
MH  - Clinical Trials as Topic/*ethics
MH  - Drug-Related Side Effects and Adverse Reactions
MH  - Humans
MH  - Informed Consent/ethics/standards
MH  - *National Academies of Science, Engineering, and Medicine, U.S., Health and
      Medicine Division
MH  - Product Surveillance, Postmarketing/*standards
MH  - United States
MH  - *United States Food and Drug Administration
EDAT- 2010/08/12 06:00
MHDA- 2010/08/13 06:00
CRDT- 2010/08/12 06:00
PHST- 2010/08/12 06:00 [entrez]
PHST- 2010/08/12 06:00 [pubmed]
PHST- 2010/08/13 06:00 [medline]
AID - 304/6/627 [pii]
AID - 10.1001/jama.2010.1080 [doi]
PST - ppublish
SO  - JAMA. 2010 Aug 11;304(6):627. doi: 10.1001/jama.2010.1080.


PMID- 20698891
OWN - NLM
STAT- MEDLINE
DCOM- 20110105
LR  - 20100921
IS  - 1472-8206 (Electronic)
IS  - 0767-3981 (Linking)
VI  - 24
IP  - 5
DP  - 2010 Oct
TI  - Strategy for clinical evaluation and screening of sudden cardiac death relatives.
PG  - 619-35
LID - 10.1111/j.1472-8206.2010.00864.x [doi]
AB  - Sudden cardiac death (SCD) may be the first and final manifestation of several
      heart diseases. In the young, SCD is often caused by a hereditary cardiac
      disease. As the most frequently seen inherited cardiac diseases have an
      autosomal-dominant pattern of inheritance, half of the first-degree relatives are
      at risk of having or developing the same disease. Therefore, screening of these
      high-risk relatives is a rational approach to reduce the incidence of SCD. To
      offer family screening and counseling, the cause of death should be carefully
      established. Autopsy is only performed in a limited number of cases. We advocate 
      for systematic autopsies in SCD, because positive findings are crucial for
      choosing the optimal screening program for the relatives. A negative autopsy
      makes identification of at-risk population difficult. However, this finding also 
      provides clues to the cardiologist, because a limited number of inherited cardiac
      diseases associated with SCD are without any structural changes. In other cases, 
      the autopsy may reveal noncardiac causes of death, which is also important for
      reassuring the relatives. However, in cases with no autopsy or negative findings,
      thorough clinical examinations and selective genetic screening of relatives may
      identify a likely diagnosis in more than 50% of affected families. There is a
      need for consensus regarding routine evaluation of SCD cases and the ethical and 
      legal framework related to postmortem testing. We propose an algorithm that
      narrows the diagnostic possibilities in apparently healthy relatives of young SCD
      victims. Molecular autopsy may play an important role.
CI  - (c) 2010 The Authors Fundamental and Clinical Pharmacology (c) 2010 Societe
      Francaise de Pharmacologie et de Therapeutique.
FAU - Ferrero-Miliani, Laura
AU  - Ferrero-Miliani L
AD  - Section of Forensic Genetics, Department of Forensic Medicine, Faculty of Health 
      Sciences, University of Copenhagen, Frederik V's Vej 11, DK-2100 Copenhagen,
      Denmark. laura.ferrero@forensic.ku.dk
FAU - Holst, Anders Gaarsdal
AU  - Holst AG
FAU - Pehrson, Steen
AU  - Pehrson S
FAU - Morling, Niels
AU  - Morling N
FAU - Bundgaard, Henning
AU  - Bundgaard H
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Fundam Clin Pharmacol
JT  - Fundamental & clinical pharmacology
JID - 8710411
SB  - IM
MH  - Algorithms
MH  - Autopsy/methods
MH  - Death, Sudden, Cardiac/etiology/*prevention & control
MH  - Genetic Predisposition to Disease
MH  - Genetic Testing/*methods
MH  - Heart Diseases/complications/*diagnosis/genetics
MH  - Humans
MH  - Mass Screening/methods
EDAT- 2010/08/12 06:00
MHDA- 2011/01/06 06:00
CRDT- 2010/08/12 06:00
PHST- 2010/08/12 06:00 [entrez]
PHST- 2010/08/12 06:00 [pubmed]
PHST- 2011/01/06 06:00 [medline]
AID - FCP864 [pii]
AID - 10.1111/j.1472-8206.2010.00864.x [doi]
PST - ppublish
SO  - Fundam Clin Pharmacol. 2010 Oct;24(5):619-35. doi:
      10.1111/j.1472-8206.2010.00864.x.


PMID- 20698403
OWN - NLM
STAT- MEDLINE
DCOM- 20101012
LR  - 20161125
IS  - 1477-7266 (Print)
IS  - 1477-7266 (Linking)
VI  - 24
IP  - 3
DP  - 2010
TI  - The ethics of data collection: unintended consequences?
PG  - 277-87
AB  - PURPOSE: The aims is to consider the political and ethical challenges involved in
      conducting ethnographic managerial/organisational behaviour research within the
      highly regulated health and social care context, in light of the emergence of
      more stringent "ethical approval" policies and requirements set by Local Research
      Ethics Committees in the United Kingdom. In the attempt and requirement to
      protect "vulnerable" employees, this paper aims to present an unintended paradox 
      of consequences when participants voluntarily revealed themselves.
      DESIGN/METHODOLOGY/APPROACH: The authors briefly review literature on research
      ethics and present an understanding of the ethical regulations currently existing
      within the British National Health Service. Within an ethnographic case study
      exploring the psychological contract, the authors consider the issues that arose 
      during one stage of data collection: a qualitative questionnaire survey with 13
      participants, including members of the lead author's team. Incorporating excerpts
      from the researcher's reflexive journal, the paper exposes the struggles of being
      an "insider" researcher and the tensions this raises for data analysis when
      participants voluntarily revealed themselves. FINDINGS: Ethnography is at "risk" 
      within health and social care and ethnographic "managerial" research is likely to
      be unduly restricted and potentially threatened. The evidence suggests that some 
      employees either did not wish to be protected or, conversely, felt compelled to
      reveal their identities, raising questions of their motivation and creating a
      paradox of unintended consequences. ORIGINALITY/VALUE: This paper offers an
      insight into the challenges of conducting nurse-managerial ethnography in
      compliance with ethical guidelines, yet disrupted by participants. The findings
      will be useful to other nurse-researchers attempting to conduct insider research.
FAU - Wainwright, Delia
AU  - Wainwright D
AD  - Bangor Business School, Bangor University, Bangor, UK.
FAU - Sambrook, Sally
AU  - Sambrook S
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Health Organ Manag
JT  - Journal of health organization and management
JID - 101179473
MH  - Anthropology, Cultural/*ethics
MH  - Data Collection/*ethics
MH  - Ethics, Research
MH  - Humans
MH  - Patient Care Team/ethics
MH  - Privacy
MH  - State Medicine/*ethics/organization & administration
MH  - United Kingdom
MH  - Workplace
EDAT- 2010/08/12 06:00
MHDA- 2010/10/13 06:00
CRDT- 2010/08/12 06:00
PHST- 2010/08/12 06:00 [entrez]
PHST- 2010/08/12 06:00 [pubmed]
PHST- 2010/10/13 06:00 [medline]
AID - 10.1108/14777261011054617 [doi]
PST - ppublish
SO  - J Health Organ Manag. 2010;24(3):277-87. doi: 10.1108/14777261011054617.


PMID- 20697997
OWN - NLM
STAT- MEDLINE
DCOM- 20101012
LR  - 20100810
IS  - 0303-7339 (Print)
IS  - 0303-7339 (Linking)
VI  - 52
IP  - 8
DP  - 2010
TI  - [Is it acceptable to use placebos in depression research?].
PG  - 575-82
AB  - The use of placebos in an investigation into the efficacy of a new type of
      treatment for winter depression was not approved by a medical ethics committee
      because some test subjects receiving placebos might thereby be deprived of an
      effective treatment. According to the authors, the committee's decision
      constituted an impediment to research and prevented a thorough investigation of a
      possible new type of treatment. In this essay it is argued that the use of
      placebos in depression research is ethically acceptable.
FAU - Meesters, Y
AU  - Meesters Y
AD  - Universitair Centrum Psychiatrie, Universitair Medisch Centrum, Groningen.
      y.meesters@psy.umcg.nl
FAU - Ruiter, M J
AU  - Ruiter MJ
FAU - Nolen, W A
AU  - Nolen WA
LA  - dut
PT  - English Abstract
PT  - Journal Article
TT  - Is het gebruik van placebo in onderzoek bij depressie aanvaardbaar?
PL  - Netherlands
TA  - Tijdschr Psychiatr
JT  - Tijdschrift voor psychiatrie
JID - 0423731
RN  - 0 (Antidepressive Agents)
RN  - 0 (Placebos)
SB  - IM
MH  - Antidepressive Agents/*therapeutic use
MH  - Depression/*drug therapy
MH  - *Ethics, Clinical
MH  - *Ethics, Research
MH  - Humans
MH  - Placebos/*therapeutic use
MH  - Treatment Outcome
EDAT- 2010/08/11 06:00
MHDA- 2010/10/13 06:00
CRDT- 2010/08/11 06:00
PHST- 2010/08/11 06:00 [entrez]
PHST- 2010/08/11 06:00 [pubmed]
PHST- 2010/10/13 06:00 [medline]
AID - TVPart_8271 [pii]
PST - ppublish
SO  - Tijdschr Psychiatr. 2010;52(8):575-82.


PMID- 20697510
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110713
LR  - 20211020
IS  - 1718-7729 (Electronic)
IS  - 1198-0052 (Linking)
VI  - 17
IP  - 4
DP  - 2010 Aug
TI  - Access to thalidomide for the treatment of multiple myeloma in Canada: physician 
      behaviours and ethical implications.
PG  - 11-9
AB  - BACKGROUND: Multiple myeloma is an incurable malignancy. Since the late 1990s,
      its management has changed with the introduction of novel agents. Thalidomide,
      which is often called a "novel" therapy, has significantly prolonged survival in 
      multiple myeloma and is considered worldwide to be part of standard of care in
      this disease. However, thalidomide is not approved in Canada, leading to problems
      with drug access for patients. METHODS: Our study surveyed Canadian hematologists
      on their thalidomide prescribing practices and difficulties with drug access. We 
      address some of the ethical issues facing patients and their doctors who are
      unable to obtain or afford the drug, and who therefore resort to alternative
      means such as illegal importation. RESULTS: Of the 411 Canadian hematologists
      contacted, 122 completed the survey, 97 reported that they did not treat myeloma,
      and 192 did not respond. Assuming that all non-responders treat myeloma, our
      estimated overall response rate from physicians who treat this disease was 39%.
      Survey participants indicated that, in Canada, access to thalidomide is a major
      issue for physicians and myeloma patients alike, and that 81% of respondents are 
      dissatisfied or very dissatisfied with the drug access process. Many physicians
      felt that the special access process for thalidomide is unduly onerous,
      influences treatment decisions, and invades patient privacy. We found that 20% of
      physicians were unaware of the legal implications of obtaining thalidomide from
      other countries and that at least 23% overtly or covertly support patients in
      obtaining the drug from a non-Health-Canada-approved source. CONCLUSIONS: The
      current lack of access to thalidomide in Canada is a concerning problem for
      patients and health care providers dealing with myeloma. Regulatory changes at
      the federal level (Health Canada) need to be re-examined to promptly resolve this
      issue.
FAU - Minuk, L
AU  - Minuk L
AD  - Division of Hematology, London Health Sciences Centre, Schulich School of
      Medicine and Dentistry, University of Western Ontario, London, ON.
      Leonard.minuk@lhsc.on.ca
FAU - Sibbald, R
AU  - Sibbald R
FAU - Peng, J
AU  - Peng J
FAU - Bejaimal, S
AU  - Bejaimal S
FAU - Chin-Yee, I
AU  - Chin-Yee I
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Curr Oncol
JT  - Current oncology (Toronto, Ont.)
JID - 9502503
PMC - PMC2913818
OTO - NOTNLM
OT  - Thalidomide
OT  - advocacy
OT  - drug access
OT  - ethics
OT  - myeloma
EDAT- 2010/08/11 06:00
MHDA- 2010/08/11 06:01
CRDT- 2010/08/11 06:00
PHST- 2010/08/11 06:00 [entrez]
PHST- 2010/08/11 06:00 [pubmed]
PHST- 2010/08/11 06:01 [medline]
AID - 10.3747/co.v17i4.644 [doi]
PST - ppublish
SO  - Curr Oncol. 2010 Aug;17(4):11-9. doi: 10.3747/co.v17i4.644.


PMID- 20697476
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1998-3727 (Electronic)
IS  - 0019-5413 (Linking)
VI  - 44
IP  - 3
DP  - 2010 Jul
TI  - Effect of neurotransmitters and bone marrow cells for neuronal regeneration in
      iatrogenic spinal cord injury: An experimental study.
PG  - 252-6
LID - 10.4103/0019-5413.65142 [doi]
AB  - BACKGROUND: Spinal cord trauma is a major health problem with associated
      physical, social, economic and psychological sequelae. Despite many advances in
      research and treatment modalities, the pathophysiology of spinal cord injury
      remains unclear, and morbidity and mortality among these patients remain high.
      This experimental study investigates the regenerative cell proliferation effects 
      of bone marrow supplemented with neurotransmitters combinations in the
      regeneration of spinal cord injury MATERIALS AND METHODS: Ethical Committee
      Clearance was obtained for animal study. All animal care and procedures were in
      accordance with the CPCSEA and National Institute of Health guidelines. Thirty
      Wistar rats with monoplegia following surgical hemitransection of the spinal cord
      were used for the study. Half of them were randomly selected as the test group
      and the rest as the control group. Spinal cord injury model of Wistar rats in the
      test group were treated by infusing a combination of neurotransmitters and bone
      marrow at the site of injury using a special polythene tube and reservoir for 21 
      days. In the control group of rats with monoplegia, normal saline was infused at 
      the site of injury for 21 days. The observations are recorded along with results.
      RESULTS: The monoplegia in the test group of rats recovered significantly (P
      value < 0.01) with supplementation of the bone marrow cells and neurotransmitters
      combination. In the control group of rats, there was no recovery. The
      reward-seeking locomotor test and sensory recovery test confirmed recovery from
      spinal cord injury in the test group with significance. CONCLUSIONS: The
      neurotransmitters and bone marrow combination was responsible for functional
      recovery in the test group of rats with experimental spinal cord injury We
      believe that the combination of neurotransmitters along with bone marrow may be a
      scope of future research in patients with spinal cord injury.
FAU - John, Ps
AU  - John P
AD  - Department of Orthopedics, Medical College, Kottayam, Kerala, India.
FAU - Paulose, Cs
AU  - Paulose C
FAU - Sreekanth, R
AU  - Sreekanth R
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Indian J Orthop
JT  - Indian journal of orthopaedics
JID - 0137736
PMC - PMC2911923
OTO - NOTNLM
OT  - Spinal cord injury
OT  - bone marrow cells
OT  - neurotransmitters
EDAT- 2010/08/11 06:00
MHDA- 2010/08/11 06:01
CRDT- 2010/08/11 06:00
PHST- 2010/08/11 06:00 [entrez]
PHST- 2010/08/11 06:00 [pubmed]
PHST- 2010/08/11 06:01 [medline]
AID - 10.4103/0019-5413.65142 [doi]
PST - ppublish
SO  - Indian J Orthop. 2010 Jul;44(3):252-6. doi: 10.4103/0019-5413.65142.


PMID- 20697473
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1998-3727 (Electronic)
IS  - 0019-5413 (Linking)
VI  - 44
IP  - 3
DP  - 2010 Jul
TI  - Ethical issues in scientific publication.
PG  - 235-7
LID - 10.4103/0019-5413.65133 [doi]
FAU - Jain, Anil K
AU  - Jain AK
AD  - Editor, Indian Journal of Orthopedics and Department of Orthopedics, University
      College of Medical Sciences and GTB Hospital, University of Delhi, Dilshad
      Garden, Delhi - 110 095, India E-mail: editor@ijoonline.com,
      dranilkjain@gmail.com.
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Indian J Orthop
JT  - Indian journal of orthopaedics
JID - 0137736
PMC - PMC2911920
EDAT- 2010/08/11 06:00
MHDA- 2010/08/11 06:01
CRDT- 2010/08/11 06:00
PHST- 2010/08/11 06:00 [entrez]
PHST- 2010/08/11 06:00 [pubmed]
PHST- 2010/08/11 06:01 [medline]
AID - 10.4103/0019-5413.65133 [doi]
PST - ppublish
SO  - Indian J Orthop. 2010 Jul;44(3):235-7. doi: 10.4103/0019-5413.65133.


PMID- 20697313
OWN - NLM
STAT- MEDLINE
DCOM- 20110107
LR  - 20220408
IS  - 1529-4242 (Electronic)
IS  - 0032-1052 (Linking)
VI  - 126
IP  - 6
DP  - 2010 Dec
TI  - Observational studies: cohort and case-control studies.
PG  - 2234-2242
LID - 10.1097/PRS.0b013e3181f44abc [doi]
AB  - Observational studies constitute an important category of study designs. To
      address some investigative questions in plastic surgery, randomized controlled
      trials are not always indicated or ethical to conduct. Instead, observational
      studies may be the next best method of addressing these types of questions.
      Well-designed observational studies have been shown to provide results similar to
      those of randomized controlled trials, challenging the belief that observational 
      studies are second rate. Cohort studies and case-control studies are two primary 
      types of observational studies that aid in evaluating associations between
      diseases and exposures. In this review article, the authors describe these study 
      designs and methodologic issues, and provide examples from the plastic surgery
      literature.
FAU - Song, Jae W
AU  - Song JW
AD  - Ann Arbor, Mich. From the Section of Plastic Surgery, Department of Surgery,
      University of Michigan Health System.
FAU - Chung, Kevin C
AU  - Chung KC
LA  - eng
GR  - F32 AR058105/AR/NIAMS NIH HHS/United States
GR  - K24 AR053120/AR/NIAMS NIH HHS/United States
GR  - K24 AR053120-01A2/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United States
TA  - Plast Reconstr Surg
JT  - Plastic and reconstructive surgery
JID - 1306050
SB  - IM
MH  - Bias
MH  - *Case-Control Studies
MH  - *Cohort Studies
MH  - *Evidence-Based Medicine
MH  - Humans
MH  - Prospective Studies
MH  - Randomized Controlled Trials as Topic
MH  - Reconstructive Surgical Procedures/*methods/*standards
MH  - Retrospective Studies
PMC - PMC2998589
MID - NIHMS237355
EDAT- 2010/08/11 06:00
MHDA- 2011/01/08 06:00
CRDT- 2010/08/11 06:00
PHST- 2010/08/11 06:00 [entrez]
PHST- 2010/08/11 06:00 [pubmed]
PHST- 2011/01/08 06:00 [medline]
AID - 10.1097/PRS.0b013e3181f44abc [doi]
AID - 00006534-201012000-00058 [pii]
PST - ppublish
SO  - Plast Reconstr Surg. 2010 Dec;126(6):2234-2242. doi:
      10.1097/PRS.0b013e3181f44abc.


PMID- 20697117
OWN - NLM
STAT- MEDLINE
DCOM- 20101029
LR  - 20110322
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 257
IP  - 1
DP  - 2010 Oct
TI  - Ligaments and plicae of the elbow: normal MR imaging variability in 60
      asymptomatic subjects.
PG  - 185-94
LID - 10.1148/radiol.10092163 [doi]
AB  - PURPOSE: To prospectively evaluate the normal variability of ligaments, plicae,
      and the posterior capitellum on conventional magnetic resonance (MR) images of
      the elbow in asymptomatic volunteers. MATERIALS AND METHODS: The study was
      approved by the institutional ethics board, and informed consent was obtained
      from all subjects. MR imaging was performed at 1.5 T in 60 asymptomatic
      volunteers (30 women, 30 men; age range, 22-51 years; median age, 32.8 years) by 
      using the following five pulse sequences: transverse T1-weighted spin-echo,
      sagittal T2-weighted fast spin-echo, coronal fast spin-echo short-inversion-time 
      inversion recovery, transverse intermediate-weighted with fat saturation, and
      coronal three-dimensional water-excitation true fast imaging with steady-state
      precession. The visibility (completely visible over the entire course, partially 
      visible, or not visible) and signal intensity characteristics (hypointense or
      hyperintense to muscle, homogeneous signal intensity vs striation) of the elbow
      ligaments and plicae were evaluated by three independent readers. The presence of
      pseudodefects at the posterior capitellum was determined. The dimensions of all
      structures were measured by two independent readers. RESULTS: The anterior ulnar 
      collateral ligament (UCL) and radial collateral ligament (RCL) were visible over 
      their entire course in all 60 subjects (100%). The posterior UCL, lateral UCL,
      and annular ligament (AL) were completely visible in 58 (97%), 51 (85%), and 59
      (98%) of the 60 subjects, respectively, and partially visible in the remaining
      subjects. Increased signal intensity with fluid-sensitive sequences was found in 
      the anterior UCL in nine of the 60 subjects (15%), posterior UCL in four subjects
      (7%), RCL in one subject (2%), lateral UCL in six subjects (10%), and AL in one
      subject (2%). The median thickness and 90th percentile were 2.5 and 3.5 mm,
      respectively, for the anterior UCL, 1.0 and 1.7 mm for the posterior UCL, 1.9 and
      2.8 mm for the RCL, 2.3 and 3.8 mm for the lateral UCL, and 1.0 and 1.3 mm for
      the AL. A posterolateral plica (median dimension, 4.3 x 1.9 x 3.9 mm) was found
      in 59 of the 60 subjects (98%), whereas a posterior plica (median dimension, 1.8 
      x 1.4 mm) could be detected in only 20 (33%). A pseudodefect of the capitellum
      was noted in 51 of the 60 subjects (85%). CONCLUSION: The elbow ligaments and the
      posterolateral plica are consistently visible on conventional MR images of
      asymptomatic subjects. Most normal ligaments are thinner than 4 mm, and most
      plicae are thinner than 3 mm.
FAU - Husarik, Daniela B
AU  - Husarik DB
AD  - Department of Radiology, University Hospital Zurich, Zurich, Switzerland.
      danielahusarik@yahoo.com
FAU - Saupe, Nadja
AU  - Saupe N
FAU - Pfirrmann, Christian W A
AU  - Pfirrmann CW
FAU - Jost, Bernhard
AU  - Jost B
FAU - Hodler, Juerg
AU  - Hodler J
FAU - Zanetti, Marco
AU  - Zanetti M
LA  - eng
PT  - Journal Article
DEP - 20100809
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
CIN - Radiologe. 2011 Feb;51(2):93-4. PMID: 21328050
MH  - Adult
MH  - Collateral Ligaments/*anatomy & histology
MH  - *Elbow
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Reference Values
MH  - Statistics, Nonparametric
EDAT- 2010/08/11 06:00
MHDA- 2010/10/30 06:00
CRDT- 2010/08/11 06:00
PHST- 2010/08/11 06:00 [entrez]
PHST- 2010/08/11 06:00 [pubmed]
PHST- 2010/10/30 06:00 [medline]
AID - radiol.10092163 [pii]
AID - 10.1148/radiol.10092163 [doi]
PST - ppublish
SO  - Radiology. 2010 Oct;257(1):185-94. doi: 10.1148/radiol.10092163. Epub 2010 Aug 9.


PMID- 20696606
OWN - NLM
STAT- MEDLINE
DCOM- 20110127
LR  - 20220408
IS  - 1096-7206 (Electronic)
IS  - 1096-7192 (Linking)
VI  - 101
IP  - 2-3
DP  - 2010 Oct-Nov
TI  - Carnitine palmitoyltransferase 1A (CPT1A) P479L prevalence in live newborns in
      Yukon, Northwest Territories, and Nunavut.
PG  - 200-4
LID - 10.1016/j.ymgme.2010.07.013 [doi]
AB  - Carnitine palmitoyltransferase 1A (CPT1A), encoded by the gene CPT1A, is the
      hepatic isoform of CPT1 and is a major regulatory point in long-chain fatty acid 
      oxidation. CPT1A deficiency confers risk for hypoketotic hypoglycaemia, hepatic
      encephalopathy, seizures, and sudden unexpected death in infancy (SUDI). It
      remains controversial whether the CPT1A gene variant, c.1436C>T (p.P479L),
      identified in Inuit, First Nations, and Alaska Native infants, causes
      susceptibility to decompensation, in particular during times of fever and
      intercurrent illness. Although newborn screening for the P479L variant occurs in 
      some jurisdictions, background knowledge about the presence of the variant in
      Canadian Aboriginal populations is lacking. In an effort to understand the
      population implications of the variant in northern Canada, overall frequencies of
      the variant were assessed. Further studies are underway to determine associated
      risk. Ethics approval was obtained from university REBs, local research
      institutes, and with consultation with territorial Aboriginal groups. Newborn
      screening blood spots from all infants born in 2006 in the three territories were
      genotyped for the p.P479L variant. p.P479L (c.1436C>T) allele frequencies in the 
      three territories were 0.02, 0.08, and 0.77 in Yukon (n=325), Northwest
      Territories (n=564), and Nunavut (n=695), respectively. Homozygosity rates were
      0%, 3%, and 64%. Aboriginal status was available only in NWT, with allele
      frequencies of 0.04, 0.44, 0.00, and 0.01 for First Nations, Inuvialuit/Inuit,
      Metis, and non-Aboriginal populations. Although individual blood spots were not
      identified for Aboriginal ethnicity in Nunavut infants, ~90% of infants in
      Nunavut are born to Inuit women. The allele frequency and rate of homozygosity
      for the CPT1A P479L variant were high in Inuit and Inuvialuit who reside in
      northern coastal regions. The variant is present at a low frequency in First
      Nations populations, who reside in areas less coastal than the Inuit or
      Inuvialuit in the two western territories. The significance of the population and
      geographic distribution remains unclear, but the high population frequencies of
      the variant suggest a historically low penetrance for adverse outcomes. Further
      evidence is needed to determine if there is an increased risk for infant
      mortality and morbidity and whether newborn screening will be indicated on a
      population basis.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Collins, Sorcha A
AU  - Collins SA
AD  - Department of Medical Genetics, University of British Columbia, Vancouver,
      British Columbia, Canada.
FAU - Sinclair, Graham
AU  - Sinclair G
FAU - McIntosh, Sarah
AU  - McIntosh S
FAU - Bamforth, Fiona
AU  - Bamforth F
FAU - Thompson, Robert
AU  - Thompson R
FAU - Sobol, Isaac
AU  - Sobol I
FAU - Osborne, Geraldine
AU  - Osborne G
FAU - Corriveau, Andre
AU  - Corriveau A
FAU - Santos, Maria
AU  - Santos M
FAU - Hanley, Brendan
AU  - Hanley B
FAU - Greenberg, Cheryl R
AU  - Greenberg CR
FAU - Vallance, Hilary
AU  - Vallance H
FAU - Arbour, Laura
AU  - Arbour L
LA  - eng
GR  - CTP-78953/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100724
PL  - United States
TA  - Mol Genet Metab
JT  - Molecular genetics and metabolism
JID - 9805456
RN  - EC 2.3.1.21 (Carnitine O-Palmitoyltransferase)
SB  - IM
MH  - Carnitine O-Palmitoyltransferase/*genetics
MH  - Gene Frequency
MH  - Humans
MH  - Infant, Newborn
MH  - Inuits/genetics
MH  - Neonatal Screening
MH  - Northwest Territories/epidemiology
MH  - Nunavut/epidemiology
MH  - Prevalence
MH  - Yukon Territory/epidemiology
EDAT- 2010/08/11 06:00
MHDA- 2011/01/29 06:00
CRDT- 2010/08/11 06:00
PHST- 2010/06/04 00:00 [received]
PHST- 2010/07/19 00:00 [revised]
PHST- 2010/07/20 00:00 [accepted]
PHST- 2010/08/11 06:00 [entrez]
PHST- 2010/08/11 06:00 [pubmed]
PHST- 2011/01/29 06:00 [medline]
AID - S1096-7192(10)00275-1 [pii]
AID - 10.1016/j.ymgme.2010.07.013 [doi]
PST - ppublish
SO  - Mol Genet Metab. 2010 Oct-Nov;101(2-3):200-4. doi: 10.1016/j.ymgme.2010.07.013.
      Epub 2010 Jul 24.


PMID- 20695808
OWN - NLM
STAT- MEDLINE
DCOM- 20101124
LR  - 20191210
IS  - 1943-2763 (Electronic)
IS  - 0885-579X (Linking)
VI  - 24
IP  - 4
DP  - 2010 Aug
TI  - "Let's get down to business: a validation study of the Psychopathic Personality
      Inventory among a sample of MBA students.".
PG  - 487-98
LID - 10.1521/pedi.2010.24.4.487 [doi]
AB  - While the Psychopathic Personality Inventory (PPI) has gained increasing
      attention as a measure of noncriminal psychopathy, absent has been research
      involving samples including business people. This study investigated the validity
      of the PPI with such a population by examining the association between
      psychopathic traits and moral decision-making among MBA students. Sixty-six MBA
      students were assessed using the PPI, the MACH-IV (a measure of
      Machiavellianism), the Ethical Position Questionnaire (EPQ), and the Defining
      Issues Test (DIT-2). Only PPI Machiavellian Egocentricity was associated with
      level of post-conventional moral reasoning. MACH-IV Machiavellianism was a
      stronger predictor of the Subjectivist ethical position than were PPI subscales. 
      However, a combination of MACH-IV Machiavellianism and four PPI scales accounted 
      for 46% of the variance in Subjectivism. Results suggested that Machiavellian
      Egocentricity and Machiavellianism are distinct constructs. Benning, Patrick,
      Hicks, Blonigen, & Krueger (2003)'s two factor model of the PPI was also
      supported. In general, the findings provided further validation for the PPI as a 
      tool for assessing psychopathic traits among "mainstream" individuals, including 
      business people.
FAU - Heinze, Peter
AU  - Heinze P
AD  - Ramapo College of New Jersey, 505 Ramapo Valley Road, Mawah, NJ 07430, USA.
      pheinze@ramapo.edu
FAU - Allen, Rhianon
AU  - Allen R
FAU - Magai, Carol
AU  - Magai C
FAU - Ritzler, Barry
AU  - Ritzler B
LA  - eng
PT  - Journal Article
PT  - Validation Study
PL  - United States
TA  - J Pers Disord
JT  - Journal of personality disorders
JID - 8710838
SB  - IM
MH  - Adult
MH  - Aggression
MH  - Antisocial Personality Disorder/*classification
MH  - Female
MH  - Humans
MH  - *Internal-External Control
MH  - Male
MH  - Morals
MH  - *Personality
MH  - Personality Inventory/*statistics & numerical data
MH  - Psychometrics
MH  - Reference Values
MH  - Reproducibility of Results
MH  - Students/*psychology
MH  - Young Adult
EDAT- 2010/08/11 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/11 06:00
PHST- 2010/08/11 06:00 [entrez]
PHST- 2010/08/11 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1521/pedi.2010.24.4.487 [doi]
AID - 10.1521/pedi.2010.24.4.487 [pii]
PST - ppublish
SO  - J Pers Disord. 2010 Aug;24(4):487-98. doi: 10.1521/pedi.2010.24.4.487.


PMID- 20695792
OWN - NLM
STAT- MEDLINE
DCOM- 20110315
LR  - 20211020
IS  - 1557-7716 (Electronic)
IS  - 1523-0864 (Linking)
VI  - 13
IP  - 12
DP  - 2010 Dec 15
TI  - De novo myocardial regeneration: advances and pitfalls.
PG  - 1867-77
LID - 10.1089/ars.2010.3388 [doi]
AB  - The capability of adult tissue-derived stem cells for cardiogenesis has been
      extensively studied in experimental animals and clinical studies for treatment of
      postischemic cardiomyopathy. The less-than-anticipated improvement in the heart
      function in most clinical studies with skeletal myoblasts and bone marrow cells
      has warranted a search for alternative sources of stem cells. Despite their
      multilineage differentiation potential, ethical issues, teratogenicity, and
      tissue rejection are main obstacles in developing clinically feasible methods for
      embryonic stem cell transplantation into patients. A decade-long research on
      embryonic stem cells has paved the way for discovery of alternative approaches
      for generating pluripotent stem cells. Genetic manipulation of somatic cells for 
      pluripotency genes reprograms the cells to pluripotent status. Efforts are
      currently focused to make reprogramming protocols safer for clinical applications
      of the reprogrammed cells. We summarize the advancements and complicating
      features of stem cell therapy and discuss the decade-and-a-half-long efforts made
      by stem cell researchers for moving the field from bench to the bedside as an
      adjunct therapy or as an alternative to the contemporary therapeutic modalities
      for routine clinical application. The review also provides a special focus on the
      advancements made in the field of somatic cell reprogramming.
FAU - Haider, Khawaja Husnain
AU  - Haider KH
AD  - Department of Pathology, University of Cincinnati , Cincinnati, Ohio 45267-0529, 
      USA.
FAU - Buccini, Stephanie
AU  - Buccini S
FAU - Ahmed, Rafeeq P H
AU  - Ahmed RP
FAU - Ashraf, Muhammad
AU  - Ashraf M
LA  - eng
GR  - HL-089535/HL/NHLBI NIH HHS/United States
GR  - HL-087246/HL/NHLBI NIH HHS/United States
GR  - R37-HL074272/HL/NHLBI NIH HHS/United States
GR  - HL-080686/HL/NHLBI NIH HHS/United States
GR  - HL-087288/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20101012
PL  - United States
TA  - Antioxid Redox Signal
JT  - Antioxidants & redox signaling
JID - 100888899
SB  - IM
MH  - Cardiomyopathies/therapy
MH  - Cell- and Tissue-Based Therapy/methods
MH  - Embryonic Stem Cells/cytology
MH  - Humans
MH  - Induced Pluripotent Stem Cells/cytology
MH  - Myocardium/*cytology
MH  - Pluripotent Stem Cells/*cytology
MH  - Stem Cell Transplantation
PMC - PMC2971636
EDAT- 2010/08/11 06:00
MHDA- 2011/03/16 06:00
CRDT- 2010/08/11 06:00
PHST- 2010/08/11 06:00 [entrez]
PHST- 2010/08/11 06:00 [pubmed]
PHST- 2011/03/16 06:00 [medline]
AID - 10.1089/ars.2010.3388 [doi]
PST - ppublish
SO  - Antioxid Redox Signal. 2010 Dec 15;13(12):1867-77. doi: 10.1089/ars.2010.3388.
      Epub 2010 Oct 12.


PMID- 20695665
OWN - NLM
STAT- MEDLINE
DCOM- 20110114
LR  - 20191210
IS  - 1939-2087 (Electronic)
IS  - 0021-9940 (Linking)
VI  - 124
IP  - 3
DP  - 2010 Aug
TI  - Behavioral science, engineering, and poetry revisited.
PG  - 336-41
LID - 10.1037/a0017355 [doi]
AB  - Forty years ago, Lehrman (1971) identified 2 orientations to the study of animal 
      behavior. The natural history orientation conducted field and lab research
      designed to reveal how animals cope with the circumstances of their natural
      environment. Such research reveals the diversity among different types of animals
      and differences between the world of animals and the world of humans (i.e.,
      "poetry"). In contrast, the anthropocentric orientation studies animals either to
      generate animal-derived general laws applicable to humans or to provide
      experimental information that, for ethical and practical reasons, cannot be
      acquired from human research. The primary motivation for the anthropocentric
      orientation is to provide workable models for investigating specifically human
      problems (i.e., "engineering"). Evidence is presented from the study of bird song
      that demonstrates the contribution that the "poetic" approach can make to
      anthropocentric ("engineering") concerns.
CI  - 2010 APA, all rights reserved
FAU - Michel, George F
AU  - Michel GF
AD  - Department of Psychology, University of North Carolina at Greensboro, Greensboro,
      NC 27402-6170, USA. gfmichel@uncg.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Comp Psychol
JT  - Journal of comparative psychology (Washington, D.C. : 1983)
JID - 8309850
SB  - IM
MH  - Animals
MH  - *Behavior, Animal
MH  - Behavioral Sciences
MH  - Critical Period, Psychological
MH  - *Engineering
MH  - Humans
MH  - Imitative Behavior
MH  - Language Development
MH  - Mental Recall
MH  - *Models, Animal
MH  - *Poetry as Topic
MH  - Songbirds
MH  - Species Specificity
MH  - Vocalization, Animal
EDAT- 2010/08/11 06:00
MHDA- 2011/01/15 06:00
CRDT- 2010/08/11 06:00
PHST- 2010/08/11 06:00 [entrez]
PHST- 2010/08/11 06:00 [pubmed]
PHST- 2011/01/15 06:00 [medline]
AID - 2010-16166-011 [pii]
AID - 10.1037/a0017355 [doi]
PST - ppublish
SO  - J Comp Psychol. 2010 Aug;124(3):336-41. doi: 10.1037/a0017355.


PMID- 20694947
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20100809
IS  - 1526-4564 (Electronic)
IS  - 1526-4564 (Linking)
VI  - 28
IP  - 4
DP  - 2010 Jul
TI  - Ethics and reproductive medicine. Preface.
PG  - 277-80
LID - 10.1055/s-0030-1255174 [doi]
FAU - Sauer, Mark V
AU  - Sauer MV
LA  - eng
PT  - Editorial
DEP - 20100806
PL  - United States
TA  - Semin Reprod Med
JT  - Seminars in reproductive medicine
JID - 100909394
SB  - IM
MH  - Aged
MH  - Female
MH  - Fertilization in Vitro/ethics/methods/trends
MH  - Humans
MH  - Male
MH  - Maternal Age
MH  - Middle Aged
MH  - Oocyte Donation/ethics/trends
MH  - Pregnancy
MH  - Reproductive Medicine/*ethics/methods/trends
EDAT- 2010/08/10 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/10 06:00
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1055/s-0030-1255174 [doi]
PST - ppublish
SO  - Semin Reprod Med. 2010 Jul;28(4):277-80. doi: 10.1055/s-0030-1255174. Epub 2010
      Aug 6.


PMID- 20694924
OWN - NLM
STAT- MEDLINE
DCOM- 20101207
LR  - 20190116
IS  - 1549-7852 (Electronic)
IS  - 1040-8398 (Linking)
VI  - 50
IP  - 7
DP  - 2010 Aug
TI  - Prediction of in vivo short-chain fatty acid production in hindgut fermenting
      mammals: problems and pitfalls.
PG  - 605-19
LID - 10.1080/10408390802565939 [doi]
AB  - Short-chain fatty acids (SCFA) are considered to have important physiological
      functions. However, to prove this, SCFA must be determined, which is rather
      difficult as a lot of factors interfere with their production. This review
      focuses on the factors that influence the prediction of short-chain fatty acid
      formation in the large intestine of monogastric mammals. To mimic the in vivo
      situation, when predicting the amount of short-chain fatty acids produced from a 
      certain substrate based on in vitro models, one has to estimate the amount of
      this substrate entering the large intestine, the retention time in the different 
      parts of the large intestine, and the substrate fermentability. Instead of in
      vitro models, direct and indirect techniques may be used to measure short-chain
      fatty acid production in vivo. Direct techniques include the measurement of input
      and output or measuring differences in SCFA between portal and venous blood
      whereas indirect techniques measure the end products of fermentation. In this
      case, other factors have to be taken into account, including technical
      limitations and ethical considerations. In this review it is concluded that the
      choice for a method will rely on the purpose of the study taking into account the
      (dis)advantages of every method.
FAU - Millet, S
AU  - Millet S
AD  - Animal Sciences Unit, Institute for Agricultural and Fisheries Research (ILVO),
      Melle, Belgium. sam.millet@ilvo.vlaanderen.be
FAU - Van Oeckel, M J
AU  - Van Oeckel MJ
FAU - Aluwe, M
AU  - Aluwe M
FAU - Delezie, E
AU  - Delezie E
FAU - De Brabander, D L
AU  - De Brabander DL
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Crit Rev Food Sci Nutr
JT  - Critical reviews in food science and nutrition
JID - 8914818
RN  - 0 (Fatty Acids, Volatile)
SB  - IM
MH  - Animals
MH  - Fatty Acids, Volatile/*metabolism
MH  - Fermentation/*physiology
MH  - Intestine, Large/*metabolism/*microbiology
MH  - Species Specificity
EDAT- 2010/08/10 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/10 06:00
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 925288735 [pii]
AID - 10.1080/10408390802565939 [doi]
PST - ppublish
SO  - Crit Rev Food Sci Nutr. 2010 Aug;50(7):605-19. doi: 10.1080/10408390802565939.


PMID- 20694916
OWN - NLM
STAT- MEDLINE
DCOM- 20100830
LR  - 20100809
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 8
DP  - 2010 Aug
TI  - Striking the right balance in research ethics and regulation.
PG  - 65
LID - 10.1080/15265161.2010.481350 [doi]
FAU - Miller, Franklin G
AU  - Miller FG
AD  - National Institutes of Health, Bethesda, MD 20892-1156, USA. fmiller@nih.gov
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2010 Aug;10(8):45-54. PMID: 20694909
CIN - Am J Bioeth. 2010 Aug;10(8):W4-6. PMID: 20694896
MH  - Behavioral Research/*ethics
MH  - Biomedical Research/*ethics
MH  - Ethics Committees, Research
MH  - Ethics, Research
MH  - Human Experimentation/*ethics/*legislation & jurisprudence
MH  - Humans
MH  - Legislation as Topic/ethics/trends
MH  - *Moral Obligations
MH  - Research Subjects/*legislation & jurisprudence
MH  - Risk
MH  - United States
EDAT- 2010/08/10 06:00
MHDA- 2010/08/31 06:00
CRDT- 2010/08/10 06:00
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2010/08/31 06:00 [medline]
AID - 925253102 [pii]
AID - 10.1080/15265161.2010.481350 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Aug;10(8):65. doi: 10.1080/15265161.2010.481350.


PMID- 20694913
OWN - NLM
STAT- MEDLINE
DCOM- 20100830
LR  - 20161125
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 8
DP  - 2010 Aug
TI  - One size does not fit all: the ethical imperative to limit the concept of
      research exceptionalism.
PG  - 60-1
LID - 10.1080/15265161.2010.482643 [doi]
FAU - McCullough, Melissa
AU  - McCullough M
AD  - Queen's University Belfast, Antrim, Northern Ireland. m.mccullough@qub.ac.uk
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
RN  - 0 (Influenza Vaccines)
SB  - IM
CON - Am J Bioeth. 2010 Aug;10(8):45-54. PMID: 20694909
CIN - Am J Bioeth. 2010 Aug;10(8):W4-6. PMID: 20694896
MH  - Clinical Trials as Topic/ethics/legislation & jurisprudence
MH  - Decision Making/*ethics
MH  - Health Personnel/statistics & numerical data
MH  - Human Experimentation/*ethics/legislation & jurisprudence
MH  - Humans
MH  - Influenza Vaccines/administration & dosage
MH  - Legislation as Topic/ethics/trends
MH  - Research Subjects/*legislation & jurisprudence
MH  - Surveys and Questionnaires
MH  - United Kingdom
MH  - United States
MH  - Vaccination/standards
EDAT- 2010/08/10 06:00
MHDA- 2010/08/31 06:00
CRDT- 2010/08/10 06:00
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2010/08/31 06:00 [medline]
AID - 925218649 [pii]
AID - 10.1080/15265161.2010.482643 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Aug;10(8):60-1. doi: 10.1080/15265161.2010.482643.


PMID- 20694909
OWN - NLM
STAT- MEDLINE
DCOM- 20100830
LR  - 20161125
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 8
DP  - 2010 Aug
TI  - Research exceptionalism.
PG  - 45-54
LID - 10.1080/15265161.2010.482630 [doi]
AB  - Research involving human subjects is much more stringently regulated than many
      other nonresearch activities that appear to be at least as risky. A number of
      prominent figures now argue that research is overregulated. We argue that the
      reasons typically offered to justify the present system of research regulation
      fail to show that research should be subject to more stringent regulation than
      other equally risky activities. However, there are three often overlooked reasons
      for thinking that research should be treated as a special case. First, research
      typically involves the imposition of risk on people who do not benefit from this 
      risk imposition. Second, research depends on public trust. Third, the complexity 
      of the moral decision making required favors ethics committees as a regulative
      solution for research.
FAU - Wilson, James
AU  - Wilson J
AD  - University College London, UK. james-gs.wilson@ucl.ac.uk
FAU - Hunter, David
AU  - Hunter D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CIN - Am J Bioeth. 2010 Aug;10(8):55-6. PMID: 20694910
CIN - Am J Bioeth. 2010 Aug;10(8):57-8. PMID: 20694911
CIN - Am J Bioeth. 2010 Aug;10(8):58-60. PMID: 20694912
CIN - Am J Bioeth. 2010 Aug;10(8):60-1. PMID: 20694913
CIN - Am J Bioeth. 2010 Aug;10(8):62-3. PMID: 20694914
CIN - Am J Bioeth. 2010 Aug;10(8):63-5. PMID: 20694915
CIN - Am J Bioeth. 2010 Aug;10(8):65. PMID: 20694916
CIN - Am J Bioeth. 2010 Aug;10(8):66-7. PMID: 20694917
CIN - Am J Bioeth. 2010 Aug;10(8):67-9. PMID: 20694918
MH  - Clinical Trials as Topic/adverse effects/*ethics/legislation & jurisprudence
MH  - Decision Making
MH  - *Ethics Committees, Research
MH  - Ethics, Research
MH  - Human Experimentation/*ethics/legislation & jurisprudence
MH  - Humans
MH  - Informed Consent/ethics
MH  - Legislation as Topic/ethics/trends
MH  - Moral Obligations
MH  - Public Opinion
MH  - Research Subjects/legislation & jurisprudence
MH  - *Risk
MH  - *Trust
MH  - Uncertainty
MH  - United Kingdom
EDAT- 2010/08/10 06:00
MHDA- 2010/08/31 06:00
CRDT- 2010/08/10 06:00
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2010/08/31 06:00 [medline]
AID - 925223295 [pii]
AID - 10.1080/15265161.2010.482630 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Aug;10(8):45-54. doi: 10.1080/15265161.2010.482630.


PMID- 20694908
OWN - NLM
STAT- MEDLINE
DCOM- 20100830
LR  - 20211203
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 8
DP  - 2010 Aug
TI  - Post-approval translational research itself has diverse ethics.
PG  - 43-4
LID - 10.1080/15265161.2010.496525 [doi]
FAU - Mukherjee, Joia
AU  - Mukherjee J
AD  - Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
      jmukherjee@pih.org
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Fluoroquinolones)
RN  - 7QVV6I50DT (alatrofloxacin)
SB  - IM
CON - Am J Bioeth. 2010 Aug;10(8):19-30. PMID: 20694901
CIN - Am J Bioeth. 2010 Aug;10(8):W1-3. PMID: 20694895
MH  - Anti-Infective Agents/therapeutic use
MH  - Clinical Trials, Phase IV as Topic/*ethics
MH  - Conflict of Interest
MH  - *Drug Approval
MH  - Drug Industry/ethics
MH  - Fluoroquinolones/therapeutic use
MH  - Humans
MH  - Informed Consent/ethics
MH  - Meningitis/drug therapy
MH  - Nigeria
MH  - Poverty
MH  - Research Support as Topic/ethics
MH  - Therapeutic Human Experimentation/ethics
MH  - Translational Research, Biomedical/*ethics
MH  - Vulnerable Populations
EDAT- 2010/08/10 06:00
MHDA- 2010/08/31 06:00
CRDT- 2010/08/10 06:00
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2010/08/31 06:00 [medline]
AID - 925223743 [pii]
AID - 10.1080/15265161.2010.496525 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Aug;10(8):43-4. doi: 10.1080/15265161.2010.496525.


PMID- 20694907
OWN - NLM
STAT- MEDLINE
DCOM- 20100830
LR  - 20211203
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 8
DP  - 2010 Aug
TI  - Diverse ethics of translational research in the developing world.
PG  - 41-2
LID - 10.1080/15265161.2010.497418 [doi]
FAU - Lang, Trudie
AU  - Lang T
AD  - University of Oxford, Centre for Tropical Medicine, Headington, United Kingdom.
      trudie.lang@ndm.ox.ac.uk
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2010 Aug;10(8):19-30. PMID: 20694901
CIN - Am J Bioeth. 2010 Aug;10(8):W1-3. PMID: 20694895
MH  - Clinical Trials as Topic/*ethics
MH  - Community-Based Participatory Research/*ethics
MH  - *Developing Countries
MH  - Ethics, Research
MH  - Humans
MH  - Therapeutic Human Experimentation/ethics
MH  - Translational Research, Biomedical/*ethics
EDAT- 2010/08/10 06:00
MHDA- 2010/08/31 06:00
CRDT- 2010/08/10 06:00
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2010/08/31 06:00 [medline]
AID - 925219398 [pii]
AID - 10.1080/15265161.2010.497418 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Aug;10(8):41-2. doi: 10.1080/15265161.2010.497418.


PMID- 20694906
OWN - NLM
STAT- MEDLINE
DCOM- 20100830
LR  - 20211203
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 8
DP  - 2010 Aug
TI  - Impediments to "T2" research: are ethics really to blame?
PG  - 39-40
LID - 10.1080/15265161.2010.492889 [doi]
FAU - Lipworth, Wendy
AU  - Lipworth W
AD  - Australian Institute of Health Innovation, University of New South Wales, NSW,
      Australia. w.lipworth@unsw.edu.au
FAU - Kerridge, Ian
AU  - Kerridge I
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2010 Aug;10(8):19-30. PMID: 20694901
CIN - Am J Bioeth. 2010 Aug;10(8):W1-3. PMID: 20694895
MH  - Clinical Trials, Phase IV as Topic/*ethics
MH  - *Drug Approval
MH  - Ethical Analysis
MH  - Ethics Committees, Research/*ethics
MH  - Ethics, Research
MH  - Humans
MH  - Therapeutic Human Experimentation/ethics
MH  - Translational Research, Biomedical/*ethics
EDAT- 2010/08/10 06:00
MHDA- 2010/08/31 06:00
CRDT- 2010/08/10 06:00
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2010/08/31 06:00 [medline]
AID - 925237670 [pii]
AID - 10.1080/15265161.2010.492889 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Aug;10(8):39-40. doi: 10.1080/15265161.2010.492889.


PMID- 20694905
OWN - NLM
STAT- MEDLINE
DCOM- 20100830
LR  - 20211203
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 8
DP  - 2010 Aug
TI  - Community engagement and the ethics of global, translational research: a response
      to Sofaer and Eyal.
PG  - 37-8
LID - 10.1080/15265161.2010.494223 [doi]
FAU - Lynch, John
AU  - Lynch J
AD  - Department of Communication, University of Cincinnati, USA. john.lynch@uc.edu
FAU - Mitchell, Monica
AU  - Mitchell M
LA  - eng
GR  - UL1 RR026314/RR/NCRR NIH HHS/United States
GR  - UL1 RR026314-01/RR/NCRR NIH HHS/United States
GR  - 1UL1RR026314-01/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2010 Aug;10(8):19-30. PMID: 20694901
CIN - Am J Bioeth. 2010 Aug;10(8):W1-3. PMID: 20694895
MH  - Clinical Trials as Topic/*ethics
MH  - Community-Based Participatory Research/*ethics
MH  - Ethics, Research
MH  - Global Health
MH  - Humans
MH  - International Cooperation
MH  - Research Personnel/ethics
MH  - Research Subjects
MH  - Researcher-Subject Relations/ethics
MH  - Translational Research, Biomedical/*ethics
MH  - Vulnerable Populations
PMC - PMC2919777
MID - NIHMS219889
EDAT- 2010/08/10 06:00
MHDA- 2010/08/31 06:00
CRDT- 2010/08/10 06:00
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2010/08/31 06:00 [medline]
AID - 925224234 [pii]
AID - 10.1080/15265161.2010.494223 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Aug;10(8):37-8. doi: 10.1080/15265161.2010.494223.


PMID- 20694903
OWN - NLM
STAT- MEDLINE
DCOM- 20100830
LR  - 20211203
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 8
DP  - 2010 Aug
TI  - Ethical analysis of translational research is more complex than distinguishing T1
      from T2.
PG  - 33-5
LID - 10.1080/15265161.2010.494227 [doi]
FAU - Allen, Bill
AU  - Allen B
AD  - University of Florida, Gainesville, 32610, USA. wmallen@ufl.edu
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2010 Aug;10(8):19-30. PMID: 20694901
CIN - Am J Bioeth. 2010 Aug;10(8):W1-3. PMID: 20694895
MH  - Clinical Trials as Topic/*ethics
MH  - Drug Approval
MH  - Ethical Analysis
MH  - Global Health
MH  - Humans
MH  - Randomized Controlled Trials as Topic/ethics
MH  - Therapeutic Equivalency
MH  - Therapeutic Human Experimentation/ethics
MH  - Translational Research, Biomedical/*ethics
MH  - United States
MH  - *Vulnerable Populations
EDAT- 2010/08/10 06:00
MHDA- 2010/08/31 06:00
CRDT- 2010/08/10 06:00
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2010/08/31 06:00 [medline]
AID - 925256361 [pii]
AID - 10.1080/15265161.2010.494227 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Aug;10(8):33-5. doi: 10.1080/15265161.2010.494227.


PMID- 20694902
OWN - NLM
STAT- MEDLINE
DCOM- 20100830
LR  - 20211203
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 8
DP  - 2010 Aug
TI  - The ethical urgency of advancing implementation science.
PG  - 31-2
LID - 10.1080/15265161.2010.494230 [doi]
FAU - Solomon, Mildred Z
AU  - Solomon MZ
AD  - Harvard Medical School, Department of Global Health&SocialMedicine, Boston, MA
      02115, USA. mildred_solomon@hms.harvard.edu
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2010 Aug;10(8):19-30. PMID: 20694901
CIN - Am J Bioeth. 2010 Aug;10(8):W1-3. PMID: 20694895
MH  - Clinical Trials as Topic/*ethics
MH  - Comparative Effectiveness Research/ethics
MH  - Evidence-Based Medicine/ethics
MH  - Humans
MH  - Therapeutic Human Experimentation/*ethics
MH  - Translational Research, Biomedical/*ethics/organization & administration
MH  - United States
EDAT- 2010/08/10 06:00
MHDA- 2010/08/31 06:00
CRDT- 2010/08/10 06:00
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2010/08/31 06:00 [medline]
AID - 925225270 [pii]
AID - 10.1080/15265161.2010.494230 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Aug;10(8):31-2. doi: 10.1080/15265161.2010.494230.


PMID- 20694901
OWN - NLM
STAT- MEDLINE
DCOM- 20100830
LR  - 20211203
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 8
DP  - 2010 Aug
TI  - The diverse ethics of translational research.
PG  - 19-30
LID - 10.1080/15265161.2010.494214 [doi]
AB  - Commentators on the ethics of translational research find it morally problematic.
      Types of translational research are said to involve questionable benefits,
      special risks, additional barriers to informed consent, and severe conflicts of
      interest. Translational research conducted on the global poor is thought to
      exploit them and increase international disparities. Some commentators support
      especially stringent ethical review. However, such concerns are grounded only in 
      pre-approval translational research (now called T1). Whether or not T1 has these 
      features, translational research beyond approval (T2: phase IV, health services, 
      and implementation research) is unlikely to and, when conducted on the global
      poor, may support development. Therefore, insofar as T1 is morally problematic,
      and no independent objections to T2 exist, the ethics of translational research
      is diverse: while some translational research is problematic, some is not.
      Funding and oversight should reflect this diversity, and T2 should be encouraged,
      particularly when conducted among the global poor.
FAU - Sofaer, Neema
AU  - Sofaer N
AD  - King's College London, Centre of Medical Law and Ethics, UK.
      neema.sofaer@kcl.ac.uk
FAU - Eyal, Nir
AU  - Eyal N
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CIN - Am J Bioeth. 2010 Aug;10(8):W1-3. PMID: 20694895
CIN - Am J Bioeth. 2010 Aug;10(8):31-2. PMID: 20694902
CIN - Am J Bioeth. 2010 Aug;10(8):33-5. PMID: 20694903
CIN - Am J Bioeth. 2010 Aug;10(8):35-7. PMID: 20694904
CIN - Am J Bioeth. 2010 Aug;10(8):37-8. PMID: 20694905
CIN - Am J Bioeth. 2010 Aug;10(8):39-40. PMID: 20694906
CIN - Am J Bioeth. 2010 Aug;10(8):41-2. PMID: 20694907
CIN - Am J Bioeth. 2010 Aug;10(8):43-4. PMID: 20694908
MH  - Clinical Trials as Topic/*ethics
MH  - Clinical Trials, Phase IV as Topic/ethics
MH  - *Conflict of Interest
MH  - Ethical Analysis
MH  - Ethics Committees, Research
MH  - Ethics, Research
MH  - Global Health
MH  - Health Services Research/ethics
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Patient Rights/ethics
MH  - *Poverty/ethics
MH  - Research Support as Topic/*ethics
MH  - Therapeutic Human Experimentation/ethics
MH  - Translational Research, Biomedical/*ethics
MH  - *Vulnerable Populations
EDAT- 2010/08/10 06:00
MHDA- 2010/08/31 06:00
CRDT- 2010/08/10 06:00
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2010/08/31 06:00 [medline]
AID - 925226683 [pii]
AID - 10.1080/15265161.2010.494214 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Aug;10(8):19-30. doi: 10.1080/15265161.2010.494214.


PMID- 20694897
OWN - NLM
STAT- MEDLINE
DCOM- 20100830
LR  - 20181201
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 8
DP  - 2010 Aug
TI  - The ethics of substituting physician assistants, nurse practitioners, and
      residents for attending physicians.
PG  - 11-3
LID - 10.1080/15265161.2010.494459 [doi]
FAU - Jecker, Nancy S
AU  - Jecker NS
AD  - University of Washington School of Medicine, Seattle, WA 98195-7120, USA.
      nsjecker@u.washington.edu
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2010 Aug;10(8):1-10. PMID: 20694894
CIN - JAAPA. 2011 Jan;24(1):51-2. PMID: 21261149
MH  - Attitude
MH  - Choice Behavior
MH  - Coercion
MH  - Comprehension
MH  - Deception
MH  - Emergency Service, Hospital/*ethics
MH  - Humans
MH  - Informed Consent/*ethics
MH  - *Internship and Residency
MH  - *Nurse Practitioners
MH  - *Patient Rights
MH  - *Personal Autonomy
MH  - *Physician Assistants
MH  - Professional-Patient Relations/ethics
MH  - Trust
MH  - *Truth Disclosure
MH  - Workforce
EDAT- 2010/08/10 06:00
MHDA- 2010/08/31 06:00
CRDT- 2010/08/10 06:00
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2010/08/31 06:00 [medline]
AID - 925228588 [pii]
AID - 10.1080/15265161.2010.494459 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Aug;10(8):11-3. doi: 10.1080/15265161.2010.494459.


PMID- 20694895
OWN - NLM
STAT- MEDLINE
DCOM- 20100830
LR  - 20211203
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 8
DP  - 2010 Aug
TI  - Translational research beyond approval: a two-stage ethics review.
PG  - W1-3
LID - 10.1080/15265161.2010.500199 [doi]
FAU - Sofaer, Neema
AU  - Sofaer N
AD  - King's College London, Centre of Medical Law and Ethics, UK.
      neema.sofaer@kcl.ac.uk
FAU - Eyal, Nir
AU  - Eyal N
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2010 Aug;10(8):19-30. PMID: 20694901
CON - Am J Bioeth. 2010 Aug;10(8):31-2. PMID: 20694902
CON - Am J Bioeth. 2010 Aug;10(8):33-5. PMID: 20694903
CON - Am J Bioeth. 2010 Aug;10(8):35-7. PMID: 20694904
CON - Am J Bioeth. 2010 Aug;10(8):37-8. PMID: 20694905
CON - Am J Bioeth. 2010 Aug;10(8):39-40. PMID: 20694906
CON - Am J Bioeth. 2010 Aug;10(8):41-2. PMID: 20694907
CON - Am J Bioeth. 2010 Aug;10(8):43-4. PMID: 20694908
MH  - Clinical Trials as Topic/*ethics
MH  - Clinical Trials, Phase IV as Topic/ethics
MH  - Community-Based Participatory Research/*ethics
MH  - Developing Countries
MH  - Drug Approval
MH  - Ethics, Research
MH  - Global Health
MH  - Humans
MH  - Informed Consent/ethics
MH  - Research Support as Topic/ethics
MH  - Researcher-Subject Relations/ethics
MH  - Therapeutic Human Experimentation/*ethics
MH  - Translational Research, Biomedical/*ethics
MH  - Trust
MH  - *Vulnerable Populations
EDAT- 2010/08/10 06:00
MHDA- 2010/08/31 06:00
CRDT- 2010/08/10 06:00
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2010/08/31 06:00 [medline]
AID - 925254535 [pii]
AID - 10.1080/15265161.2010.500199 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Aug;10(8):W1-3. doi: 10.1080/15265161.2010.500199.


PMID- 20694763
OWN - NLM
STAT- MEDLINE
DCOM- 20110114
LR  - 20211020
IS  - 1563-258X (Electronic)
IS  - 0043-5341 (Linking)
VI  - 160
IP  - 13-14
DP  - 2010 Jul
TI  - [Palliative sedation therapy for severe dyspnoea].
PG  - 338-42
LID - 10.1007/s10354-009-0735-z [doi]
AB  - In this case study we report on a patient with advanced myxofibrosarcoma and lung
      metastases, suffering from severe dyspnoea. Symptoms were not manageable by means
      of standard palliative care, which made palliative sedation therapy necessary in 
      order to alleviate dyspnoea. On the basis of this case study, indications, drugs,
      therapy monitoring and ethical aspects of palliative sedation therapy are
      discussed.
FAU - Schippinger, Walter
AU  - Schippinger W
AD  - Abteilung fur Innere Medizin, Albert Schweitzer Klinik, Graz, Austria.
      walter.schippinger@stadt.graz.at
FAU - Weixler, Dietmar
AU  - Weixler D
FAU - Muller-Busch, Christof
AU  - Muller-Busch C
LA  - ger
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - Palliative Sedierung zur Symptomkontrolle massiver Dyspnoe.
PL  - Austria
TA  - Wien Med Wochenschr
JT  - Wiener medizinische Wochenschrift (1946)
JID - 8708475
SB  - IM
MH  - Aged
MH  - *Conscious Sedation
MH  - Dyspnea/*psychology/*therapy
MH  - Humans
MH  - Lung Neoplasms/*psychology/*secondary/therapy
MH  - Male
MH  - Myxosarcoma/*psychology/*secondary/therapy
MH  - Palliative Care/*psychology
MH  - Pulmonary Embolism/psychology/therapy
MH  - Referral and Consultation
MH  - Soft Tissue Neoplasms/*psychology/therapy
EDAT- 2010/08/10 06:00
MHDA- 2011/01/15 06:00
CRDT- 2010/08/10 06:00
PHST- 2009/07/02 00:00 [received]
PHST- 2009/09/11 00:00 [accepted]
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2011/01/15 06:00 [medline]
AID - 10.1007/s10354-009-0735-z [doi]
PST - ppublish
SO  - Wien Med Wochenschr. 2010 Jul;160(13-14):338-42. doi: 10.1007/s10354-009-0735-z.


PMID- 20694762
OWN - NLM
STAT- MEDLINE
DCOM- 20110114
LR  - 20211020
IS  - 1563-258X (Electronic)
IS  - 0043-5341 (Linking)
VI  - 160
IP  - 13-14
DP  - 2010 Jul
TI  - [Ethical discussion of palliative sedation].
PG  - 331-7
LID - 10.1007/s10354-010-0813-2 [doi]
AB  - This article discusses ethical implications of palliative sedation at the end of 
      life. Terminal or palliative sedation, like other denominations are discussed in 
      literature, which invite to a profound discussion. From an ethical point of view,
      terminal or palliative sedation seems to be a way out when in intolerable
      suffering or situations without prospects, the demand for euthanasia arises. The 
      possibility to use palliative sedation for effective control of otherwise
      refractory suffering provokes the question if it even can be used with the
      intention to hasten death. This has led to ethical concerns on the use and limits
      of sedation. Therefore it seems to be necessary to elaborate clear guidelines in 
      handling sedation in end-of-life care to prevent misuse. The contribution of
      ethical considerations can clarify the position and use of palliative sedation.
FAU - Virt, Gunter
AU  - Virt G
AD  - Institut fur Moraltheologie, Universitat Wien, Wien, Austria.
FAU - Hunstorfer, Karl
AU  - Hunstorfer K
LA  - ger
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - Ethische Uberlegungen zur palliativen Sedierung.
PL  - Austria
TA  - Wien Med Wochenschr
JT  - Wiener medizinische Wochenschrift (1946)
JID - 8708475
SB  - IM
MH  - Aged
MH  - Austria
MH  - Combined Modality Therapy
MH  - Conscious Sedation/*ethics/psychology
MH  - Dyspnea/*psychology
MH  - Humans
MH  - Informed Consent/psychology
MH  - Lung Neoplasms/psychology/*secondary
MH  - Male
MH  - Myxosarcoma/psychology/*secondary
MH  - Palliative Care/*ethics
MH  - Patient Participation/psychology
MH  - Soft Tissue Neoplasms/*psychology/therapy
MH  - Terminal Care/ethics/psychology
EDAT- 2010/08/10 06:00
MHDA- 2011/01/15 06:00
CRDT- 2010/08/10 06:00
PHST- 2010/01/17 00:00 [received]
PHST- 2010/04/14 00:00 [accepted]
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2011/01/15 06:00 [medline]
AID - 10.1007/s10354-010-0813-2 [doi]
PST - ppublish
SO  - Wien Med Wochenschr. 2010 Jul;160(13-14):331-7. doi: 10.1007/s10354-010-0813-2.


PMID- 20694761
OWN - NLM
STAT- MEDLINE
DCOM- 20110114
LR  - 20211020
IS  - 1563-258X (Electronic)
IS  - 0043-5341 (Linking)
VI  - 160
IP  - 13-14
DP  - 2010 Jul
TI  - [Percutaneous endoscopic gastrostomy-tube for a patient with glioblastoma to
      enable his admission into a nursing home].
PG  - 328-30
LID - 10.1007/s10354-010-0778-1 [doi]
AB  - The medical care for people in the end-stage of their carcinoma-disease demands
      extensive medical and nursing resources. If the admission to a hospice is not
      possible because of financial and personal reasons, or the medical care at home
      cannot be fulfilled personnel, a medical care in a nursing home would be possible
      for some patients on condition that a stable general condition and the support of
      mobile palliative teams are given. Besides a practicable pain therapy and the
      control of symptoms the hydration and ingestion are the criteria for the approval
      to a possible admission to a nursing home. If the ingestion is only limited
      possible respectively impossible and no advance directive respectively nor
      provision full power can be submitted, the admission is often denied, because
      mainly the people occupying a nursing profession are afraid to be situated in an 
      ethic or lawful dispute situation, despite comprehensive information.
FAU - Schmidt, Elisabeth
AU  - Schmidt E
AD  - Palliativstation, Krankenhaus der Elisabethinen, Graz, Austria.
      elisabeth.schmidt@elisabethinen.at
LA  - ger
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - PEG-Sonde fur einen Patienten mit Glioblastom, um seine Aufnahme in ein
      Pflegeheim zu ermoglichen?
PL  - Austria
TA  - Wien Med Wochenschr
JT  - Wiener medizinische Wochenschrift (1946)
JID - 8708475
SB  - IM
MH  - Astrocytoma/pathology/*psychology/radiotherapy/surgery
MH  - Brain Neoplasms/pathology/*psychology/radiotherapy/surgery
MH  - Combined Modality Therapy
MH  - Disease Progression
MH  - Enteral Nutrition/nursing/*psychology
MH  - Gastrostomy/nursing/*psychology
MH  - Germany
MH  - Glioblastoma/pathology/*psychology/radiotherapy/surgery
MH  - Humans
MH  - Legal Guardians
MH  - Male
MH  - Neoplasm Staging
MH  - *Nursing Homes
MH  - Palliative Care/methods/*psychology
MH  - *Patient Admission
MH  - Terminal Care/psychology
EDAT- 2010/08/10 06:00
MHDA- 2011/01/15 06:00
CRDT- 2010/08/10 06:00
PHST- 2009/06/01 00:00 [received]
PHST- 2010/01/14 00:00 [accepted]
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2011/01/15 06:00 [medline]
AID - 10.1007/s10354-010-0778-1 [doi]
PST - ppublish
SO  - Wien Med Wochenschr. 2010 Jul;160(13-14):328-30. doi: 10.1007/s10354-010-0778-1.


PMID- 20694421
OWN - NLM
STAT- MEDLINE
DCOM- 20101004
LR  - 20190608
IS  - 0104-1169 (Print)
IS  - 0104-1169 (Linking)
VI  - 18 Spec No
DP  - 2010 May-Jun
TI  - [Nursing students knowledge about alcohol and drugs].
PG  - 529-34
LID - S0104-11692010000700007 [pii]
AB  - The aim of this study was to verify the knowledge of nursing students regarding
      the use of alcohol and other drugs, particularly addiction, tolerance, withdrawal
      and intoxication, the reasons students give for drug addiction and commencement, 
      and personal interest in the issue of drug use. A descriptive-exploratory design 
      was used, with a sample of 44 students, by applying a semi-structured
      questionnaire, constructed by the researchers based on the objectives, with open 
      and closed questions, totaling 24 points. Ethical procedures were followed and
      data were submitted to exploratory descriptive analysis. It was shown that
      students knowledge is still limited, comprehension about a patients reasons for
      using and becoming addicted is incomplete and the interest is current.
FAU - Vilela, Miriam Vargas
AU  - Vilela MV
AD  - Universidad Mayor de San Andres, La Paz, Bolivia. miriam_vilela2004@yahoo.com
FAU - Ventura, Carla Aparecida Arena
AU  - Ventura CA
FAU - da Silva, Edilaine Cristina
AU  - da Silva EC
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Conocimientos de estudiantes de enfermeria sobre alcohol y drogas.
PL  - Brazil
TA  - Rev Lat Am Enfermagem
JT  - Revista latino-americana de enfermagem
JID - 9420934
MH  - *Alcoholism
MH  - *Attitude
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - *Students, Nursing
MH  - *Substance-Related Disorders
MH  - Surveys and Questionnaires
EDAT- 2010/08/10 06:00
MHDA- 2010/10/05 06:00
CRDT- 2010/08/10 06:00
PHST- 2008/07/21 00:00 [received]
PHST- 2009/06/08 00:00 [accepted]
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2010/10/05 06:00 [medline]
AID - S0104-11692010000700007 [pii]
AID - 10.1590/s0104-11692010000700007 [doi]
PST - ppublish
SO  - Rev Lat Am Enfermagem. 2010 May-Jun;18 Spec No:529-34. doi:
      10.1590/s0104-11692010000700007.


PMID- 20694325
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20190907
IS  - 1678-4561 (Electronic)
IS  - 1413-8123 (Linking)
VI  - 15
IP  - 4
DP  - 2010 Jul
TI  - [Undergraduate on Public Health: limits and possibilities as a professional
      education strategy].
PG  - 2029-38
LID - S1413-81232010000400017 [pii]
AB  - This article aims to call into question Public Health as a field for
      professionalization by systematizing theoretical, social and ethical-political
      bases for undergraduate education. We also attempt to record the trajectory in
      formulating undergraduate courses in that field and, more recently, the emergence
      of these projects in Brazilian Universities. In Brazil, the current projects are 
      a result of institutional experience gained in Public Health teaching in
      different undergraduate courses in the field of health. Additionally, there is
      also a teaching tradition in non-degree and master's and PhD graduate courses.
      International experiences from similar courses, as well as orientation from
      international agencies represent important information for such initiatives.
      Furthermore, policies targeting social inclusion and the expansion in the number 
      of student places in higher education have been propelling the movement. There is
      also the realization that the Brazilian Public Health System demands new actors
      able to provide answers which are both different and complementary to those
      offered by traditional undergraduate courses. While several institutions are in
      the stage of offering this education to society, this article presents a set of
      elements which are derived from reflection in the epistemological, sociological
      and political-sanitary spheres.
FAU - Bosi, Maria Lucia Magalhaes
AU  - Bosi ML
AD  - Departamento de Saude Comunitaria, Faculdade de Medicina, Universidade Federal do
      Ceara, Fortaleza, CE, 21943-570, Brazil. malubosi@ufc.br
FAU - Paim, Jairnilson Silva
AU  - Paim JS
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Graduacao em Saude Coletiva: limites e possibilidades como estrategia de formacao
      profissional.
PL  - Brazil
TA  - Cien Saude Colet
JT  - Ciencia & saude coletiva
JID - 9713483
SB  - IM
MH  - Brazil
MH  - Education/standards
MH  - Public Health/*education
EDAT- 2010/08/10 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/10 06:00
PHST- 2009/06/10 00:00 [received]
PHST- 2009/11/30 00:00 [accepted]
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S1413-81232010000400017 [pii]
AID - 10.1590/s1413-81232010000400017 [doi]
PST - ppublish
SO  - Cien Saude Colet. 2010 Jul;15(4):2029-38. doi: 10.1590/s1413-81232010000400017.


PMID- 20694295
OWN - NLM
STAT- MEDLINE
DCOM- 20110201
LR  - 20130702
IS  - 1699-5198 (Electronic)
IS  - 0212-1611 (Linking)
VI  - 25
IP  - 4
DP  - 2010 Jul-Aug
TI  - Life quality of postsurgical patients with colorectal cancer after supplemented
      diet with agaricus sylvaticus fungus.
PG  - 586-96
LID - S0212-16112010000400010 [pii]
AB  - INTRODUCTION: Therapeutical alternatives, directed to improve life quality and
      reduce adverse effects of cancer treatment, have been the purpose of studies that
      try to prove the immunomodulator efficacy of medicinal fungi as coadjuvant for
      conventional therapies. OBJECTIVE: The objective of this study was to evaluate
      the impact on the life quality of post-surgical patients with colorectal cancer
      after supplemented diet with Agaricus sylvaticus fungus cultivated in Brazil.
      METHODS: Randomized, double-blind, placebo-controlled clinical trial carried out 
      at the Federal District Base Hospital-Brazil, for six months. Samples of 56
      enrolled patients (24 men and 32 women), stadium phases I, II and III, separated 
      as placebo and Agaricus sylvaticus (30 mg/kg/day) supplemented groups.
      Form-standard and direct anamnesis-standard were used to evaluate indicators for 
      life quality. The method of analysis was qualitative and descriptive, processed
      with Microsoft Excel 2003 and Epi Info 2004 programs. The protocol was approved
      by the Ethics Research Committee-Health Department-Federal District. RESULTS:
      After six months of treatment, the supplemented group had increased adhesion to
      physical activity; improved disposition and good mood; reduced complaints of
      pains and alterations of sleep such as insomnia and restless sleep; presenting
      more appetite, reduced constipation, diarrhea, alternate diarrhea/constipation,
      flatulence, flatus retention, pyrosis, postprandial fullness, nausea, abdominal
      distention and abdominal pain, facts not observed in the placebo group.
      CONCLUSIONS: The results suggest that a dietary supplement with Agaricus
      sylvaticus fungus is capable of improving the life quality of patients with
      colorectal cancer in post-surgical phase.
FAU - Costa Fortes, R
AU  - Costa Fortes R
AD  - Science and Education School Sena Aires, University of Brasilia, Brasilia, DF,
      Brazil. renatacfortes@yahoo.com.br
FAU - Lacorte Recova, V
AU  - Lacorte Recova V
FAU - Lima Melo, A
AU  - Lima Melo A
FAU - Carvalho Garbi Novaes, M R
AU  - Carvalho Garbi Novaes MR
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Spain
TA  - Nutr Hosp
JT  - Nutricion hospitalaria
JID - 9100365
SB  - IM
MH  - Adult
MH  - *Agaricus
MH  - Aged
MH  - Aged, 80 and over
MH  - Colorectal Neoplasms/*surgery
MH  - *Dietary Supplements
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Quality of Life
EDAT- 2010/08/10 06:00
MHDA- 2011/02/02 06:00
CRDT- 2010/08/10 06:00
PHST- 2009/08/03 00:00 [received]
PHST- 2009/08/18 00:00 [accepted]
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2011/02/02 06:00 [medline]
AID - S0212-16112010000400010 [pii]
PST - ppublish
SO  - Nutr Hosp. 2010 Jul-Aug;25(4):586-96.


PMID- 20693739
OWN - NLM
STAT- MEDLINE
DCOM- 20100910
LR  - 20211020
IS  - 1548-6869 (Electronic)
IS  - 1049-2089 (Linking)
VI  - 21
IP  - 3
DP  - 2010 Aug
TI  - HIV testing and treatment with correctional populations: people, not prisoners.
PG  - 977-85
LID - 10.1353/hpu.0.0351 [doi]
AB  - Institutional policies, practices, and norms can impede the delivery of ethical
      standard-of-care treatment for people with HIV in correctional settings. In this 
      commentary, we focus on the fundamental issues that must be addressed to create
      an ethical environment in which best medical practices can be implemented when
      working with correctional populations. Thus, we consider ethical issues related
      to access to services, patient privacy, confidentiality, informed consent for
      testing and treatment, and issues related to the provision of services in an
      institutional setting in which maintenance of security is the primary mission.
      Medical providers must understand and navigate the dehumanization inherent in
      most correctional settings, competing life demands for incarcerated individuals, 
      power dynamics within the correctional system, and the needs of family and
      significant others who remain in the community.
FAU - Seal, David Wyatt
AU  - Seal DW
AD  - Center for AIDS Intervention Research, Medical College of Wisconsin, Milwaukee,
      WI 53202, USA. dseal@mcw.edu
FAU - Eldridge, Gloria D
AU  - Eldridge GD
FAU - Zack, Barry
AU  - Zack B
FAU - Sosman, James
AU  - Sosman J
LA  - eng
GR  - P30 MH052776-15/MH/NIMH NIH HHS/United States
GR  - P30 MH052776-07/MH/NIMH NIH HHS/United States
GR  - P30 MH052776-08/MH/NIMH NIH HHS/United States
GR  - P30 MH052776-17/MH/NIMH NIH HHS/United States
GR  - P30 MH052776-10/MH/NIMH NIH HHS/United States
GR  - P30 MH052776-11/MH/NIMH NIH HHS/United States
GR  - P30 MH052776-09/MH/NIMH NIH HHS/United States
GR  - P30 MH052776-14/MH/NIMH NIH HHS/United States
GR  - P30 MH052776-13/MH/NIMH NIH HHS/United States
GR  - P30 MH052776-08S1/MH/NIMH NIH HHS/United States
GR  - P30 MH052776/MH/NIMH NIH HHS/United States
GR  - P30 MH052776-12/MH/NIMH NIH HHS/United States
GR  - P30 MH052776-06/MH/NIMH NIH HHS/United States
GR  - P30 MH052776-16A1/MH/NIMH NIH HHS/United States
GR  - P30-MH52776/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Health Care Poor Underserved
JT  - Journal of health care for the poor and underserved
JID - 9103800
SB  - IM
MH  - Confidentiality/ethics
MH  - Delivery of Health Care/*ethics
MH  - HIV Infections/prevention & control/*therapy
MH  - Health Services Accessibility/ethics
MH  - Humans
MH  - Informed Consent/ethics
MH  - *Organizational Policy
MH  - *Prisoners
MH  - Prisons/organization & administration
PMC - PMC4107388
MID - NIHMS232477
EDAT- 2010/08/10 06:00
MHDA- 2010/09/11 06:00
CRDT- 2010/08/10 06:00
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2010/09/11 06:00 [medline]
AID - S1548686910300167 [pii]
AID - 10.1353/hpu.0.0351 [doi]
PST - ppublish
SO  - J Health Care Poor Underserved. 2010 Aug;21(3):977-85. doi: 10.1353/hpu.0.0351.


PMID- 20693482
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20151119
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 9
DP  - 2010 Sep
TI  - How the public responded to the Schiavo controversy: evidence from letters to
      editors.
PG  - 571-3
LID - 10.1136/jme.2010.037804 [doi]
AB  - The history and genesis of major public clinical ethics controversies is
      intimately related to the publication of opinions and responses in media
      coverage. To provide a sample of public response in the media, this paper reports
      the results of a content analysis of letters to editors published in the four
      most prolific American newspapers for the Schiavo controversy. Opinions expressed
      in the letters sampled strongly supported the use of living wills and strongly
      condemned public attention to the case as well as political interventions.
      Letters tended to be against withdrawal of life support, proxy consent and
      associated procedures as well as against court decisions and legal procedures. In
      comparison with reports written by journalists, letters to editors contained
      fewer controversial claims about Schiavo''s neurological condition and
      behavioural repertoire but similar loaded language to describe withdrawal of life
      support. Distinct public discourses can be encountered in different stakeholders 
      suggesting complex and extensive pluralism even within the media.
FAU - Racine, Eric
AU  - Racine E
AD  - Neuroethics Research Unit, Office 1535, IRCM, 110 Pine Avenue West, Montreal,
      Quebec H2W 1R7, Canada. Eric.racine@ircm.qc.ca
FAU - Karczewska, Marta
AU  - Karczewska M
FAU - Seidler, Matthew
AU  - Seidler M
FAU - Amaram, Rakesh
AU  - Amaram R
FAU - Illes, Judy
AU  - Illes J
LA  - eng
GR  - R01 NS045831-04/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20100806
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Awareness/physiology
MH  - Female
MH  - Humans
MH  - Living Wills/*psychology
MH  - Mass Media
MH  - Mental Competency/*legislation & jurisprudence/psychology
MH  - *Newspapers as Topic
MH  - Persistent Vegetative State/*psychology
MH  - Proxy
MH  - *Public Opinion
MH  - United States
EDAT- 2010/08/10 06:00
MHDA- 2011/11/16 06:00
CRDT- 2010/08/10 06:00
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - jme.2010.037804 [pii]
AID - 10.1136/jme.2010.037804 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Sep;36(9):571-3. doi: 10.1136/jme.2010.037804. Epub 2010 Aug
      6.


PMID- 20693306
OWN - NLM
STAT- MEDLINE
DCOM- 20110303
LR  - 20210102
IS  - 1557-3125 (Electronic)
IS  - 1541-7786 (Linking)
VI  - 8
IP  - 9
DP  - 2010 Sep
TI  - Personalized medicine: marking a new epoch in cancer patient management.
PG  - 1175-87
LID - 10.1158/1541-7786.MCR-10-0264 [doi]
AB  - Personalized medicine (PM) is defined as "a form of medicine that uses
      information about a person's genes, proteins, and environment to prevent,
      diagnose, and treat disease." The promise of PM has been on us for years. The
      suite of clinical applications of PM in cancer is broad, encompassing screening, 
      diagnosis, prognosis, prediction of treatment efficacy, patient follow-up after
      surgery for early detection of recurrence, and the stratification of patients
      into cancer subgroup categories, allowing for individualized therapy. PM aims to 
      eliminate the "one size fits all" model of medicine, which has centered on
      reaction to disease based on average responses to care. By dividing patients into
      unique cancer subgroups, treatment and follow-up can be tailored for each
      individual according to disease aggressiveness and the ability to respond to a
      certain treatment. PM is also shifting the emphasis of patient management from
      primary patient care to prevention and early intervention for high-risk
      individuals. In addition to classic single molecular markers, high-throughput
      approaches can be used for PM including whole genome sequencing,
      single-nucleotide polymorphism analysis, microarray analysis, and mass
      spectrometry. A common trend among these tools is their ability to analyze many
      targets simultaneously, thus increasing the sensitivity, specificity, and
      accuracy of biomarker discovery. Certain challenges need to be addressed in our
      transition to PM including assessment of cost, test standardization, and ethical 
      issues. It is clear that PM will gradually continue to be incorporated into
      cancer patient management and will have a significant impact on our health care
      in the future.
CI  - (c) 2010 AACR.
FAU - Diamandis, Maria
AU  - Diamandis M
AD  - Department of Laboratory Medicine, University of Toronto, Toronto, Canada.
FAU - White, Nicole M A
AU  - White NM
FAU - Yousef, George M
AU  - Yousef GM
LA  - eng
GR  - 86490/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100806
PL  - United States
TA  - Mol Cancer Res
JT  - Molecular cancer research : MCR
JID - 101150042
SB  - IM
MH  - Humans
MH  - Neoplasms/classification/diagnosis/genetics/*therapy
MH  - Patient Care Management/*trends
MH  - Precision Medicine/*trends
EDAT- 2010/08/10 06:00
MHDA- 2011/03/04 06:00
CRDT- 2010/08/10 06:00
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2011/03/04 06:00 [medline]
AID - 1541-7786.MCR-10-0264 [pii]
AID - 10.1158/1541-7786.MCR-10-0264 [doi]
PST - ppublish
SO  - Mol Cancer Res. 2010 Sep;8(9):1175-87. doi: 10.1158/1541-7786.MCR-10-0264. Epub
      2010 Aug 6.


PMID- 20692775
OWN - NLM
STAT- MEDLINE
DCOM- 20110311
LR  - 20141120
IS  - 1773-0430 (Electronic)
IS  - 0150-9918 (Linking)
VI  - 39
IP  - 8
DP  - 2010 Dec
TI  - [Contributions of the ex vivo human perfused placenta in the study of placental
      transfer of drugs].
PG  - 601-5
LID - 10.1016/j.jgyn.2010.06.010 [doi]
AB  - Perfused human placental lobule was developed during the 1970s. Only this model
      respects the anatomical features of the human placenta. This approach allows
      different technical conditions (concentrations of drugs...) without ethical
      problems. Limitations of this ex vivo model are detailed in this review, also its
      recent contributions in better understanding of placental passage of drugs.
CI  - Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
FAU - Ceccaldi, P-F
AU  - Ceccaldi PF
AD  - Service de gynecologie-obstetrique, hopital Beaujon, GHU Nord, AP-HP, universite 
      Paris-7, 100, boulevard du General-Leclerc, 92100 Clichy, France.
      pfceccaldi@gmail.com
FAU - Mandelbrot, L
AU  - Mandelbrot L
FAU - Farinotti, R
AU  - Farinotti R
FAU - Forestier, F
AU  - Forestier F
FAU - Gil, S
AU  - Gil S
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Apports de la perfusion ex vivo du cotyledon humain dans l'etude du passage
      placentaire des medicaments.
DEP - 20100807
PL  - France
TA  - J Gynecol Obstet Biol Reprod (Paris)
JT  - Journal de gynecologie, obstetrique et biologie de la reproduction
JID - 0322206
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Biological Transport
MH  - Female
MH  - Humans
MH  - In Vitro Techniques
MH  - Maternal-Fetal Exchange
MH  - Models, Biological
MH  - Perfusion
MH  - Pharmaceutical Preparations/*metabolism
MH  - Pharmacokinetics
MH  - Placenta/*metabolism
MH  - Pregnancy
EDAT- 2010/08/10 06:00
MHDA- 2011/03/12 06:00
CRDT- 2010/08/10 06:00
PHST- 2009/08/03 00:00 [received]
PHST- 2010/06/06 00:00 [revised]
PHST- 2010/06/14 00:00 [accepted]
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2011/03/12 06:00 [medline]
AID - S0368-2315(10)00187-0 [pii]
AID - 10.1016/j.jgyn.2010.06.010 [doi]
PST - ppublish
SO  - J Gynecol Obstet Biol Reprod (Paris). 2010 Dec;39(8):601-5. doi:
      10.1016/j.jgyn.2010.06.010. Epub 2010 Aug 7.


PMID- 20692660
OWN - NLM
STAT- MEDLINE
DCOM- 20110302
LR  - 20101011
IS  - 1879-1484 (Electronic)
IS  - 0021-9150 (Linking)
VI  - 212
IP  - 2
DP  - 2010 Oct
TI  - Research integrity and publication ethics.
PG  - 383-5
LID - 10.1016/j.atherosclerosis.2010.01.050 [doi]
AB  - The basic principle for professional conduct of science in all countries and all 
      disciplines is honesty towards oneself and towards others. Therefore it is utmost
      important that the scientific community prevents scientific misconduct by
      fostering research integrity. This commentary reports on the experience of a
      German 'Ombudsman' and relates it to the international concepts of good
      scientific practice as well as the questions of publication ethics. Biomedical
      research seems to be most susceptible for scientific misconduct since
      internationally we see many of the cases in this field. Here possible
      explanations for the observed misconduct are discussed as well as ways to prevent
      it. The intention is to both alert scientists and ultimately to adjust the
      scientific system in a way which allows the next generation of scientists to
      develop their careers in true research integrity.
CI  - Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Beisiegel, Ulrike
AU  - Beisiegel U
AD  - University Hospital Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg,
      Germany. beisiegel@uke.uni-hamburg.de
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100218
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
SB  - IM
MH  - Biomedical Research/*ethics
MH  - *Ethics, Research
MH  - Humans
MH  - Publishing/*ethics
MH  - Scientific Misconduct/ethics
EDAT- 2010/08/10 06:00
MHDA- 2011/03/03 06:00
CRDT- 2010/08/10 06:00
PHST- 2010/01/28 00:00 [received]
PHST- 2010/01/29 00:00 [accepted]
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2011/03/03 06:00 [medline]
AID - S0021-9150(10)00099-7 [pii]
AID - 10.1016/j.atherosclerosis.2010.01.050 [doi]
PST - ppublish
SO  - Atherosclerosis. 2010 Oct;212(2):383-5. doi:
      10.1016/j.atherosclerosis.2010.01.050. Epub 2010 Feb 18.


PMID- 20692441
OWN - NLM
STAT- MEDLINE
DCOM- 20110114
LR  - 20100809
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 42
IP  - 6
DP  - 2010 Jul-Aug
TI  - Safety of bone marrow stem cell donation: a review.
PG  - 2192-4
LID - 10.1016/j.transproceed.2010.05.029 [doi]
AB  - Allogeneic hematopoietic stem cell transplantation (HSCT) represents the first
      choice of treatment or an important therapeutic option for several diseases, but 
      it is still marked by morbidity and mortality. In contrast, the donation of
      hematopoietic stem cells (HSCs) is considered to be a safe procedure. The
      invaluable ethical source of donation and its central role in transplantation
      implies that the greatest attention be due to the donor and to the donation
      process through a serious monitoring protocol for donor safety. Both the Joint
      Accreditation Committee and the European Committee pay particular attention to
      the notification of adverse events and adverse reactions. Bone marrow donation is
      a well established procedure, that has now been performed for >30 years. Although
      it does not require drug administration, there is hospital admission for 1-3 days
      with 7-10 days off work. The main risk is related to the anesthesia. Pain in the 
      aspiration area, together with astenia are considered to be the most frequent
      side effects, as shown by the USA National Marrow Donor Program experience in
      1,193 donations. In the European Group for Blood and Marrow Transplantation
      analysis performed between 1993 and 2005 on 27,770 first HSCTs from bone marrow, 
      only 1 fatal event (pulmonary embolism) and 12 serious adverse events were
      observed. The most frequent adverse events were cardiac. The incidence of adverse
      events was significantly lower (P < .05) compared with peripheral blood HSC
      donors, which confirms the necessity of accurate attention to donor selection and
      evaluation in bone marrow donation.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Bosi, A
AU  - Bosi A
AD  - Bone Marrow Transplantation Unit, Department of Hematology, University of
      Florence, Italy. a.bosi@dac.unifi.it
FAU - Bartolozzi, B
AU  - Bartolozzi B
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - Bone Marrow Cells/*cytology
MH  - Bone Marrow Transplantation/adverse effects/methods/*standards
MH  - Donor Selection/*standards
MH  - Ethics, Medical
MH  - Humans
MH  - Ilium/cytology
MH  - Randomized Controlled Trials as Topic
MH  - Safety
MH  - Stem Cell Transplantation/adverse effects/*standards
MH  - Stem Cells/cytology
MH  - Tissue Donors/*statistics & numerical data
EDAT- 2010/08/10 06:00
MHDA- 2011/01/15 06:00
CRDT- 2010/08/10 06:00
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2011/01/15 06:00 [medline]
AID - S0041-1345(10)00687-1 [pii]
AID - 10.1016/j.transproceed.2010.05.029 [doi]
PST - ppublish
SO  - Transplant Proc. 2010 Jul-Aug;42(6):2192-4. doi:
      10.1016/j.transproceed.2010.05.029.


PMID- 20692428
OWN - NLM
STAT- MEDLINE
DCOM- 20110114
LR  - 20100809
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 42
IP  - 6
DP  - 2010 Jul-Aug
TI  - In vitro production of multigene transgenic blastocysts via sperm-mediated gene
      transfer allows rapid screening of constructs to be used in xenotransplantation
      experiments.
PG  - 2142-5
LID - 10.1016/j.transproceed.2010.05.115 [doi]
AB  - Multigene transgenic pigs would be of benefit for large animal models and in
      particular for xenotransplantation, where extensive genetic manipulation of donor
      pigs is required to make them suitable for organ grafting to humans. We have
      previously produced multitransgenic pigs via sperm-mediated gene transfer (SMGT) 
      using integrative constructs expressing 3 different reporter genes. The aim of
      the present work was to evaluate the efficacy and safety of using 3 integrative
      constructs carrying 3 different human genes involved in the modulation of
      inflammatory responses. We developed an in vitro fertilization system to
      demonstrate that SMGT can be used to efficiently produce multigene transgenic
      embryos through a 1-step genetic modification using multiple integrative
      constructs each carrying a different human gene involved in the modulation of
      inflammatory processes (hHO1, hCD39, and hCD73). The results suggest that this
      system allowed an effective preliminary test of transgenesis optimization,
      greatly reducing the number of animals used in the experiments and fulfilling
      important ethical issues. We performed 5 in vitro fertilization experiments using
      sperm cells preincubated with all 3 integrative constructs. A total of 1,498
      oocytes were fertilized to obtain 775 embryos, among which 340 further developed 
      into blastocysts. We did not observe any toxicity related to the transgenesis
      procedure that affected normal embryo development. We observed 68.5% transgenesis
      efficiency. Blastocysts were 48% single, 31% double, and 21% triple transgenic.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Vargiolu, A
AU  - Vargiolu A
AD  - Department of Surgical Sciences, University of Milano-Bicocca, Italy.
FAU - Manzini, S
AU  - Manzini S
FAU - de Cecco, M
AU  - de Cecco M
FAU - Bacci, M L
AU  - Bacci ML
FAU - Forni, M
AU  - Forni M
FAU - Galeati, G
AU  - Galeati G
FAU - Cerrito, M G
AU  - Cerrito MG
FAU - Busnelli, M
AU  - Busnelli M
FAU - Lavitrano, M
AU  - Lavitrano M
FAU - Giovannoni, R
AU  - Giovannoni R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - Animals
MH  - *Animals, Genetically Modified
MH  - Blastocyst/cytology/*physiology
MH  - Embryo, Mammalian/physiology
MH  - Female
MH  - Fertilization in Vitro/methods
MH  - Gene Transfer Techniques
MH  - Genes, Reporter
MH  - Humans
MH  - Inflammation/prevention & control
MH  - Male
MH  - Oocytes/cytology/*physiology
MH  - Spermatozoa/*physiology
MH  - Swine/embryology/*genetics
MH  - Transplantation, Heterologous/*methods
EDAT- 2010/08/10 06:00
MHDA- 2011/01/15 06:00
CRDT- 2010/08/10 06:00
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2011/01/15 06:00 [medline]
AID - S0041-1345(10)00780-3 [pii]
AID - 10.1016/j.transproceed.2010.05.115 [doi]
PST - ppublish
SO  - Transplant Proc. 2010 Jul-Aug;42(6):2142-5. doi:
      10.1016/j.transproceed.2010.05.115.


PMID- 20692423
OWN - NLM
STAT- MEDLINE
DCOM- 20110114
LR  - 20100809
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 42
IP  - 6
DP  - 2010 Jul-Aug
TI  - Some ethical aspects of xenotransplantation in light of the proposed European
      directive on the protection of animals used for scientific purposes.
PG  - 2122-5
LID - 10.1016/j.transproceed.2010.05.085 [doi]
AB  - Unlike what has happened in other times, society in general and especially the
      scientific community has become aware that animals share our sensitivity to pain 
      and the capacity to suffer. In this regard, it is generally accepted that animals
      must be protected from all types of abuse. In fact, it is unavoidable today that 
      animals used in scientific experiments enjoy the maximum degree of protection and
      well-being. This view is based on an ecocentric notion of living matter as
      opposed to the traditional anthropocentric approach because it has become evident
      that ethics should not be limited to those belonging to the same species.
      Likewise, there is a broad consensus-with the exception of members of certain
      animal protection groups-regarding the need to experiment with animals, when no
      alternative methods (AM) are available, given that the current state of
      scientific knowledge still does not allow for this type of experimentation to be 
      entirely abolished. Nevertheless, we must keep in mind that not every scientific 
      procedure in which animals are used is legitimate. On one side of the scale that 
      symbolizes the legislation in this field, we find the weight of science and
      safety, and on the other side, the weight of ethics. In this article we have
      reviewed some of the main ethical criteria that serve as a basis to balance the
      scale, in other words, to guide and legalize animal experimentation in the field 
      of xenotransplantation (XT). To that end, we take into account the current
      revisions made to the European Directive regarding the welfare of animals used in
      scientific procedures (86/609/EEC), in order to reflect, in turn, on the
      following issue: where is European institutional ethics headed on this issue?
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Jorqui-Azofra, M
AU  - Jorqui-Azofra M
AD  - Inter-University Chair BBVA Foundation-Provincial Government of Biscay in Law and
      the Human Genome University of Deusto and University of the Basque Country,
      Bilbao, Spain. mjorqui@genomelaw.deusto.es
FAU - Romeo-Casabona, C M
AU  - Romeo-Casabona CM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - Animal Testing Alternatives/ethics/legislation & jurisprudence
MH  - Animal Welfare/*ethics/legislation & jurisprudence/standards
MH  - Animals
MH  - Bioethics
MH  - *Ethics, Medical
MH  - Europe
MH  - Humans
MH  - Spain
MH  - Transplantation, Heterologous/*ethics/legislation & jurisprudence
EDAT- 2010/08/10 06:00
MHDA- 2011/01/15 06:00
CRDT- 2010/08/10 06:00
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2011/01/15 06:00 [medline]
AID - S0041-1345(10)00750-5 [pii]
AID - 10.1016/j.transproceed.2010.05.085 [doi]
PST - ppublish
SO  - Transplant Proc. 2010 Jul-Aug;42(6):2122-5. doi:
      10.1016/j.transproceed.2010.05.085.


PMID- 20692422
OWN - NLM
STAT- MEDLINE
DCOM- 20110114
LR  - 20151119
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 42
IP  - 6
DP  - 2010 Jul-Aug
TI  - A survey of the attitudes of scientists toward xenotransplantation in Taiwan.
PG  - 2117-21
LID - 10.1016/j.transproceed.2010.05.086 [doi]
AB  - This study examined the attitudes of scientists in Taiwan's leading animal
      research institution toward xenotransplantation. The aim was primarily to
      evaluate the opinions of professionals in the biomedical field on key issues
      including ethical moral, legal, and regulatory issues raised by the
      biotechnology. A secondary objective was to identify potential factors that
      influenced opinions. A questionnaire-based survey was used to evaluate opinions. 
      A test for internal consistency of the questionnaires to sample of 91 scientists 
      was performed as well as a principal component analysis. We evaluated
      associations between variables using the nonparametric Kruskal-Wallis test. Among
      the subjects 85.2% thought that xenotransplantation can be more beneficial than
      harmful to human society and 94.3% believed that it is important to develop
      xenotransplantation. Also, 97.8% of participants believed that legislative
      guidelines should be adopted to regulate research in biotechnology. Gender was an
      influencing factor, whereas, variables such as religion, marital status, and age 
      did not have obvious effects. Further studies on the general public are needed to
      detect other factors and to examine the attitude of nonprofessionals toward
      xenotransplantation.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Yen, S-Y
AU  - Yen SY
AD  - Department of Management of Technology, Feng Chia University, Seatwen, Taichung, 
      Taiwan, R.O.C. syyen@fcu.edu.tw
FAU - Lee, S-M
AU  - Lee SM
FAU - Tu, C-F
AU  - Tu CF
FAU - Tang, S-M
AU  - Tang SM
FAU - Tapsoba, J D D
AU  - Tapsoba JD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - Academies and Institutes
MH  - Adult
MH  - Animals
MH  - Attitude to Health
MH  - Biotechnology/ethics/legislation & jurisprudence
MH  - *Data Collection
MH  - Educational Status
MH  - Female
MH  - Humans
MH  - Male
MH  - Marital Status
MH  - Middle Aged
MH  - Morals
MH  - Religion
MH  - Science/ethics
MH  - Surveys and Questionnaires
MH  - Taiwan
MH  - Transplantation, Heterologous/*ethics/legislation & jurisprudence
MH  - Young Adult
EDAT- 2010/08/10 06:00
MHDA- 2011/01/15 06:00
CRDT- 2010/08/10 06:00
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2011/01/15 06:00 [medline]
AID - S0041-1345(10)00751-7 [pii]
AID - 10.1016/j.transproceed.2010.05.086 [doi]
PST - ppublish
SO  - Transplant Proc. 2010 Jul-Aug;42(6):2117-21. doi:
      10.1016/j.transproceed.2010.05.086.


PMID- 20691727
OWN - NLM
STAT- MEDLINE
DCOM- 20110111
LR  - 20211020
IS  - 1872-678X (Electronic)
IS  - 0165-0270 (Linking)
VI  - 192
IP  - 2
DP  - 2010 Oct 15
TI  - A new rodent behavioral paradigm for studying forelimb movement.
PG  - 228-32
LID - 10.1016/j.jneumeth.2010.07.040 [doi]
AB  - The center-out task is a standard paradigm often used to study the neural control
      of reaching movements in human and non-human primates. However, there are several
      disadvantages to the use of monkeys, notably costs, infrastructural requirements,
      and ethical considerations. Here we describe a similar task designed to examine
      forelimb movements in rats. Rats were trained to grasp a joystick with their
      forepaw and use it to control the movements of a sipper tube in two dimensions.
      The rats learned to move the joystick in four directions with at least 70%
      accuracy after about 45 days of training. In addition, rats were able to learn a 
      reversed mapping between joystick and sipper tube movement. This is a more
      complicated behavior than has been previously demonstrated for rats, and it could
      allow more motor behavior studies to be conducted in rodents instead of monkeys. 
      We currently are using this behavior to decode the rats' forelimb movements from 
      their brain signals.
CI  - Copyright (c) 2010 Elsevier B.V. All rights reserved.
FAU - Slutzky, Marc W
AU  - Slutzky MW
AD  - Department of Neurology, Northwestern University Feinberg School of Medicine,
      Chicago, IL 60611, United States. mslutzky@md.northwestern.edu
FAU - Jordan, Luke R
AU  - Jordan LR
FAU - Bauman, Matthew J
AU  - Bauman MJ
FAU - Miller, Lee E
AU  - Miller LE
LA  - eng
GR  - K08 NS060223/NS/NINDS NIH HHS/United States
GR  - R01 NS048845/NS/NINDS NIH HHS/United States
GR  - R01NS048845/NS/NINDS NIH HHS/United States
GR  - K08NS060223/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100805
PL  - Netherlands
TA  - J Neurosci Methods
JT  - Journal of neuroscience methods
JID - 7905558
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*physiology
MH  - Electromyography
MH  - Forelimb/*physiology
MH  - Learning/*physiology
MH  - Movement/*physiology
MH  - Psychomotor Performance/*physiology
MH  - Rats
MH  - Rats, Long-Evans
MH  - Rats, Sprague-Dawley
MH  - Signal Processing, Computer-Assisted
PMC - PMC2943042
MID - NIHMS231413
EDAT- 2010/08/10 06:00
MHDA- 2011/01/12 06:00
CRDT- 2010/08/10 06:00
PHST- 2010/04/15 00:00 [received]
PHST- 2010/07/21 00:00 [revised]
PHST- 2010/07/28 00:00 [accepted]
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2011/01/12 06:00 [medline]
AID - S0165-0270(10)00415-2 [pii]
AID - 10.1016/j.jneumeth.2010.07.040 [doi]
PST - ppublish
SO  - J Neurosci Methods. 2010 Oct 15;192(2):228-32. doi:
      10.1016/j.jneumeth.2010.07.040. Epub 2010 Aug 5.


PMID- 20691557
OWN - NLM
STAT- MEDLINE
DCOM- 20101201
LR  - 20191210
IS  - 1873-5134 (Electronic)
IS  - 0738-3991 (Linking)
VI  - 80
IP  - 3
DP  - 2010 Sep
TI  - Can patient-provider interaction increase the effectiveness of medical treatment 
      or even substitute it?--an exploration on why and how to study the specific
      effect of the provider.
PG  - 307-14
LID - 10.1016/j.pec.2010.07.020 [doi]
AB  - OBJECTIVE: Numerous studies demonstrate the impact of high-quality
      patient-provider interaction (PPI) on health outcomes. However, transformation of
      these findings into clinical practice is still a crucial problem. One reason
      might be that health communication research rarely investigated whether PPI can
      increase the effectiveness of medical treatment and/or even substitute it.
      Therefore, our objective was to provide empirical and methodological background
      of why and how to investigate the specific effect of the provider on patients'
      health outcomes. METHODS: This is a debate paper based on a narrative
      (non-systematic) literature review in Medline and PsycINFO without any year
      limitation. RESULTS: Neurobiological evidence based on expectation and
      conditioning theory indicates that PPI is able to increase the effectiveness of
      medical treatment. Moreover, the use of creative RCT study designs described in
      this paper enables health communication researchers to investigate whether PPI is
      able to substitute medical treatment. CONCLUSION: This paper exemplifies that
      there exist an evidence-based knowledge from neurobiology as well as creative RCT
      designs which enable researcher to investigate the specific effects of PPI.
      PRACTICE IMPLICATIONS: Research on the specific effects of PPI requires intense
      reflection on which patient groups or types of illness are reasonable, suitable, 
      and ethically justifiable for interventions.
CI  - Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Neumann, Melanie
AU  - Neumann M
AD  - Faculty of Health in Foundation, Gerhard Kienle Institute for Medical Theory,
      Integrative and Anthroposophic Medicine, Intgrated Curriculum for Anthroposophic 
      Medicine, Private University of Witten/Herdecke, Germany.
      melanie.neumann@uni-wh.de
FAU - Edelhauser, Friedrich
AU  - Edelhauser F
FAU - Kreps, Gary L
AU  - Kreps GL
FAU - Scheffer, Christian
AU  - Scheffer C
FAU - Lutz, Gabriele
AU  - Lutz G
FAU - Tauschel, Diethard
AU  - Tauschel D
FAU - Visser, Adriaan
AU  - Visser A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20100805
PL  - Ireland
TA  - Patient Educ Couns
JT  - Patient education and counseling
JID - 8406280
MH  - *Communication
MH  - Conditioning, Psychological
MH  - Evidence-Based Practice
MH  - Humans
MH  - *Outcome Assessment, Health Care
MH  - *Physician-Patient Relations
MH  - *Placebo Effect
MH  - Randomized Controlled Trials as Topic
EDAT- 2010/08/10 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/10 06:00
PHST- 2010/03/31 00:00 [received]
PHST- 2010/07/11 00:00 [revised]
PHST- 2010/07/14 00:00 [accepted]
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S0738-3991(10)00421-0 [pii]
AID - 10.1016/j.pec.2010.07.020 [doi]
PST - ppublish
SO  - Patient Educ Couns. 2010 Sep;80(3):307-14. doi: 10.1016/j.pec.2010.07.020. Epub
      2010 Aug 5.


PMID- 20691556
OWN - NLM
STAT- MEDLINE
DCOM- 20101201
LR  - 20130715
IS  - 1873-5134 (Electronic)
IS  - 0738-3991 (Linking)
VI  - 80
IP  - 3
DP  - 2010 Sep
TI  - Student voices in Readers' Theater: exploring communication in the hidden
      curriculum.
PG  - 354-7
LID - 10.1016/j.pec.2010.07.024 [doi]
AB  - OBJECTIVE: During the clerkship years, students often discover a misalignment
      between formal preclinical communication skills teaching and the actual practices
      of housestaff and attending role models. We developed a workshop for medical
      educators to identify how the hidden curriculum models (or fails to model)
      effective communication skills. WORKSHOP DESIGN: Using Readers' Theater,
      participants enacted and then discussed a scenario designed to trigger
      reflection. The script was adapted from an in-depth student narrative describing 
      her team's use of a derogatory term to label a patient. The student must decide
      whether and how to respond. WORKSHOP OUTCOMES: Participants discussed potential
      responses to breaches of professionalism medical hierarchy, ethical conflict
      centered on conforming pressure, "holding ambivalence", and gender inequality in 
      medicine. A number of communication options for the student were considered, and 
      role-played. CONCLUSION: The use of student narratives in medical education helps
      learners better understand the content and nuance of the hidden curriculum.
      Readers' Theater is a powerful tool to actively invite learners to step into the 
      shoes of trainees in order to glean additional perspectives. Engaging educators
      in the task of collaborative solution building using this format can help improve
      learning environments.
CI  - Copyright (c) 2010. Published by Elsevier Ireland Ltd.
FAU - Bell, Sigall K
AU  - Bell SK
AD  - Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical
      School, Boston, MA 02215, USA. Sbell1@bidmc.harvard.edu
FAU - Wideroff, Matthew
AU  - Wideroff M
FAU - Gaufberg, Liz
AU  - Gaufberg L
LA  - eng
PT  - Journal Article
DEP - 20100805
PL  - Ireland
TA  - Patient Educ Couns
JT  - Patient education and counseling
JID - 8406280
MH  - Clinical Clerkship/*methods
MH  - *Communication
MH  - *Curriculum
MH  - Faculty, Medical
MH  - Female
MH  - Humans
MH  - Male
MH  - Narration
MH  - Physician's Role
MH  - Students, Medical/*psychology
MH  - Teaching/*standards
EDAT- 2010/08/10 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/10 06:00
PHST- 2010/03/30 00:00 [received]
PHST- 2010/07/15 00:00 [revised]
PHST- 2010/07/17 00:00 [accepted]
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S0738-3991(10)00425-8 [pii]
AID - 10.1016/j.pec.2010.07.024 [doi]
PST - ppublish
SO  - Patient Educ Couns. 2010 Sep;80(3):354-7. doi: 10.1016/j.pec.2010.07.024. Epub
      2010 Aug 5.


PMID- 20691416
OWN - NLM
STAT- MEDLINE
DCOM- 20101206
LR  - 20110302
IS  - 1097-6868 (Electronic)
IS  - 0002-9378 (Linking)
VI  - 203
IP  - 5
DP  - 2010 Nov
TI  - Pelvic magnetic resonance imaging for assessment of the efficacy of the Prolift
      system for pelvic organ prolapse.
PG  - 504.e1-5
LID - 10.1016/j.ajog.2010.06.034 [doi]
AB  - OBJECTIVE: The purpose of this study was to compare pre- and postoperative pelvic
      organ prolapse-quantification (POP-Q) and magnetic resonance imaging (MRI)
      measurements in patients who undergo total Prolift (Ethicon, Inc, Somerville, NJ)
      colpopexy. STUDY DESIGN: Pre- and postoperative MRI and POP-Q examinations were
      performed on patients with stage 2 or greater prolapse who underwent the Prolift 
      procedure. MRI measurements were taken at maximum descent. Correlations between
      changes in MRI and POP-Q measurements were determined. RESULTS: Ten subjects were
      enrolled. On MRI, statistically significant changes were seen with cystocele,
      enterocele, and apex. Statistically significant changes were seen on POP-Q
      measurements for Aa, Ba, C, Ap, Bp, and GH. Positive correlations were
      demonstrated between POP-Q and MRI changes. Minimal tissue reaction was seen on
      MRI. CONCLUSION: The Prolift system is effective in the surgical management of
      pelvic organ prolapse as measured by POP-Q and MRI. Postoperative MRIs support
      the inert nature of polypropylene mesh.
CI  - Copyright (c) 2010 Mosby, Inc. All rights reserved.
FAU - Kasturi, Seshadri
AU  - Kasturi S
AD  - Division of Female Pelvic Medicine and Reconstructive Surgery, Department of
      Obstetrics and Gynecology, Indianapolis, IN, USA.
FAU - Lowman, Joye K
AU  - Lowman JK
FAU - Kelvin, Frederick M
AU  - Kelvin FM
FAU - Akisik, Fatih M
AU  - Akisik FM
FAU - Terry, Colin L
AU  - Terry CL
FAU - Hale, Douglass S
AU  - Hale DS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100805
PL  - United States
TA  - Am J Obstet Gynecol
JT  - American journal of obstetrics and gynecology
JID - 0370476
SB  - IM
EIN - Am J Obstet Gynecol. 2011 Feb;204(2):166. Lowman, Joye [corrected to Lowman, Joye
      K]; Akisik, Fateh [corrected to Akisik, Fatih M]; Terry, Colin [corrected to
      Terry, Colin L]
MH  - Aged
MH  - Female
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Middle Aged
MH  - Patient Satisfaction
MH  - Pelvic Organ Prolapse/*surgery
MH  - Pelvis/*surgery
MH  - Prospective Studies
MH  - Surgical Mesh
MH  - Treatment Outcome
EDAT- 2010/08/10 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/10 06:00
PHST- 2010/01/10 00:00 [received]
PHST- 2010/05/08 00:00 [revised]
PHST- 2010/06/15 00:00 [accepted]
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S0002-9378(10)00809-4 [pii]
AID - 10.1016/j.ajog.2010.06.034 [doi]
PST - ppublish
SO  - Am J Obstet Gynecol. 2010 Nov;203(5):504.e1-5. doi: 10.1016/j.ajog.2010.06.034.
      Epub 2010 Aug 5.


PMID- 20691328
OWN - NLM
STAT- MEDLINE
DCOM- 20101124
LR  - 20220317
IS  - 1873-622X (Electronic)
IS  - 0005-7967 (Linking)
VI  - 48
IP  - 8
DP  - 2010 Aug
TI  - Testing a new cognitive behavioural treatment for obesity: A randomized
      controlled trial with three-year follow-up.
PG  - 706-13
LID - 10.1016/j.brat.2010.03.008 [doi]
AB  - It is remarkably difficult for people with obesity to maintain a new lower weight
      following weight loss. The aim of the present study was to examine the immediate 
      and longer-term effects of a new cognitive behavioural treatment that was
      explicitly designed to minimise this post-treatment weight regain. One hundred
      and fifty female participants with obesity were randomized to the new treatment, 
      behaviour therapy (the leading alternative psychological treatment) or guided
      self-help (a minimal intervention). Both of the main treatments resulted in an
      average weight loss of about ten percent of initial weight whereas weight loss
      was more modest with guided self-help. The participants were subsequently
      followed-up for three years post-treatment. The great majority regained almost
      all the weight that they had lost with the new treatment being no better than the
      behavioural treatment in preventing weight regain. These findings lend further
      support to the notion that obesity is resistant to psychological methods of
      treatment, if anything other than a short-term perspective is taken. It is
      suggested that it is ethically questionable to claim that psychological
      treatments for obesity "work" in the absence of data on their longer-term
      effects.
CI  - Copyright 2010 Elsevier Ltd. All rights reserved.
FAU - Cooper, Zafra
AU  - Cooper Z
AD  - Oxford University, Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, 
      United Kingdom. zafra.cooper@psych.ox.ac.uk
FAU - Doll, Helen A
AU  - Doll HA
FAU - Hawker, Deborah M
AU  - Hawker DM
FAU - Byrne, Susan
AU  - Byrne S
FAU - Bonner, Gillie
AU  - Bonner G
FAU - Eeley, Elizabeth
AU  - Eeley E
FAU - O'Connor, Marianne E
AU  - O'Connor ME
FAU - Fairburn, Christopher G
AU  - Fairburn CG
LA  - eng
GR  - 046386/Z/95/A/WT_/Wellcome Trust/United Kingdom
GR  - 079113/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Behav Res Ther
JT  - Behaviour research and therapy
JID - 0372477
SB  - IM
CIN - Behav Res Ther. 2010 Aug;48(8):714-6. PMID: 20691329
MH  - Adult
MH  - Behavior Therapy/methods
MH  - Body Weight
MH  - Bulimia/therapy
MH  - Cognitive Behavioral Therapy/*methods
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Obesity/psychology/*therapy
MH  - Quality of Life
MH  - Treatment Failure
PMC - PMC2923743
EDAT- 2010/08/10 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/10 06:00
PHST- 2009/10/30 00:00 [received]
PHST- 2010/03/03 00:00 [revised]
PHST- 2010/03/09 00:00 [accepted]
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S0005-7967(10)00042-2 [pii]
AID - 10.1016/j.brat.2010.03.008 [doi]
PST - ppublish
SO  - Behav Res Ther. 2010 Aug;48(8):706-13. doi: 10.1016/j.brat.2010.03.008.


PMID- 20691142
OWN - NLM
STAT- MEDLINE
DCOM- 20110503
LR  - 20191111
IS  - 1488-2353 (Electronic)
IS  - 0147-958X (Linking)
VI  - 33
IP  - 4
DP  - 2010 Aug 1
TI  - A framework for resolving disagreement during end of life care in the critical
      care unit.
PG  - E240-53
AB  - BACKGROUND: End-of-life decisions regarding the administration, withdrawal or
      withholding of life-sustaining therapy in the critical care setting can be
      challenging. Disagreements between health care providers and family members
      occur, especially when families believe strongly in preserving life, and
      physicians are resistant to providing medically "futile" care. Such disagreements
      can cause tension and moral distress among families and clinicians. PURPOSE: To
      outline the roles and responsibilities of physicians, substitute decision makers,
      and the judicial system when decisions must be made on behalf of incapable
      persons, and to provide a framework for conflict resolution during end-of-life
      decision-making for physicians practicing in Canada. SOURCE: We used a case-based
      example to illustrate our objectives. We employed a comprehensive approach to
      understanding end-of-life decision making that included: 1) a search for relevant
      literature; 2) a review of provincial college policies; 3) a review of provincial
      legislation on consent; 4) a consultation with two bioethicists and 5) a
      consultation with two legal experts in health law. PRINCIPAL FINDINGS: In Canada,
      laws about substitute decision-making for health care are primarily provincial or
      territorial. Thus, laws and policies from professional regulatory bodies on
      end-of-life care vary across the country. We tabulated the provincial college
      policies on end-of-life care and the provincial legislation on consent and
      advance directives, and constructed a 10-step approach to conflict resolution.
      CONCLUSION: Knowledge of underlying ethical principles, understanding of
      professional duties, and adoption of a process for mediation and conflict
      resolution are essential to ensuring that physicians and institutions act
      responsibly in maintaining a patients' best interests in the context of
      family-centred care.
FAU - Choong, Karen
AU  - Choong K
AD  - Department of Pediatrics and Critical Care, McMaster Children's Hospital,
      McMaster University, Hamilton, Ontario. choongk@mcmaster.ca
FAU - Cupido, Cynthia
AU  - Cupido C
FAU - Nelson, Erin
AU  - Nelson E
FAU - Arnold, Donald M
AU  - Arnold DM
FAU - Burns, Karen
AU  - Burns K
FAU - Cook, Deborah
AU  - Cook D
FAU - Meade, Maureen
AU  - Meade M
CN  - ACCADEMY
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100801
PL  - Canada
TA  - Clin Invest Med
JT  - Clinical and investigative medicine. Medecine clinique et experimentale
JID - 7804071
SB  - IM
CIN - Clin Invest Med. 2010;33(4):E219-22. PMID: 20691139
MH  - Critical Care/legislation & jurisprudence/*methods/standards
MH  - *Decision Making
MH  - *Dissent and Disputes
MH  - Evidence-Based Medicine
MH  - Humans
MH  - *Intensive Care Units
MH  - Life Support Care/legislation & jurisprudence/*methods/standards
MH  - Ontario
MH  - Physician-Patient Relations
MH  - *Professional-Family Relations
IR  - Adhikari N
FIR - Adhikari, Neill
IR  - Arnold D
FIR - Arnold, Donald
IR  - Burns KE
FIR - Burns, Karen E A
IR  - Choong K
FIR - Choong, Karen
IR  - Cook DJ
FIR - Cook, Deborah J
IR  - Cupido C
FIR - Cupido, Cynthia
IR  - Duffett M
FIR - Duffett, Mark
IR  - Koo K
FIR - Koo, Karen
IR  - Lamontagne F
FIR - Lamontagne, Francois
IR  - Lim W
FIR - Lim, Wendy
IR  - Meade MO
FIR - Meade, Maureen O
EDAT- 2010/08/10 06:00
MHDA- 2011/05/04 06:00
CRDT- 2010/08/10 06:00
PHST- 2010/08/06 00:00 [received]
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2011/05/04 06:00 [medline]
AID - 10.25011/cim.v33i4.14227 [doi]
PST - epublish
SO  - Clin Invest Med. 2010 Aug 1;33(4):E240-53. doi: 10.25011/cim.v33i4.14227.


PMID- 20690919
OWN - NLM
STAT- MEDLINE
DCOM- 20101206
LR  - 20100809
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 24
IP  - 7
DP  - 2010 Sep
TI  - The ethics of intercountry adoption: why it matters to healthcare providers and
      bioethicists.
PG  - 358-64
LID - 10.1111/j.1467-8519.2010.01832.x [doi]
AB  - The goal of this paper is both modest and ambitious. The modest goal is to show
      that intercountry adoption should be considered by ethicists and healthcare
      providers. The more ambitious goal is to introduce the many ethical issues that
      intercountry adoption raises. Intercountry adoption is an alternative to medical,
      assisted reproduction option such as in vitro fertilization (IVF),
      intracytoplasmic sperm injection, third party egg and sperm donation and
      surrogacy. Health care providers working with assisted reproduction are in a
      unique position to introduce their clients to intercountry adoption; however,
      providers should only do so if intercountry adoption is ethically equal or
      superior to the alternatives. This paper first presents a brief history of
      intercountry adoption. The second section compares intercountry adoption with
      medical alternatives. The third section examines the unique ethical challenges
      that are not shared by other medical alternatives. The final section concludes
      that it is simplistic for a healthcare provider to promote intercountry adoption 
      unconditionally; however, in situation where intercountry adoption is practiced
      conscientiously it poses no greater ethical concern than several medical
      alternatives. This conclusion is preliminary and is intended as a start for
      further discussion.
FAU - Jones, Sarah
AU  - Jones S
AD  - University of Toronto, Ontario M5S 2C5, Canada. se.jones@utoronto.ca
LA  - eng
PT  - Journal Article
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - *Adoption/legislation & jurisprudence
MH  - Altruism
MH  - Bioethical Issues
MH  - Child
MH  - *Child Welfare
MH  - Female
MH  - Health Personnel/ethics
MH  - Humans
MH  - Infant
MH  - *Internationality
MH  - Male
EDAT- 2010/08/10 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/10 06:00
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - BIOT1832 [pii]
AID - 10.1111/j.1467-8519.2010.01832.x [doi]
PST - ppublish
SO  - Bioethics. 2010 Sep;24(7):358-64. doi: 10.1111/j.1467-8519.2010.01832.x.


PMID- 20690917
OWN - NLM
STAT- MEDLINE
DCOM- 20101206
LR  - 20220330
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 24
IP  - 7
DP  - 2010 Sep
TI  - Care ethics and the global practice of commercial surrogacy.
PG  - 333-40
LID - 10.1111/j.1467-8519.2010.01831.x [doi]
AB  - This essay will focus on the moral issues relating to surrogacy in the global
      context, and will critique the liberal arguments that have been offered in
      support of it. Liberal arguments hold sway concerning reproductive arrangements
      made between commissioning couples from wealthy nations and the surrogates from
      socioeconomically weak backgrounds that they hire to do their reproductive labor.
      My argument in this paper is motivated by a concern for controlling harms by
      putting the practice of globalized commercial surrogacy into the context of care 
      ethics. As I will argue, the unstable situations into which children of global
      surrogacy arrangements are born is symbolic of the crisis of care that the
      practice raises. Using the Baby Manji case as my touch point, I will suggest that
      liberalism cannot address the harms experienced by Manji and children like her
      who are created through the global practice of assisted reproductive technology. 
      I will argue that, if commissioning couples consider their proposed surrogacy
      contracts from a care ethics point of view, they will begin to think relationally
      about their actions, considering the practice from an ethical lens, not just an
      economic or contractual one.
FAU - Parks, Jennifer A
AU  - Parks JA
AD  - Loyola University, Department of Philosophy, 1032 West Sheridan Road, Chicago,
      Illinois 60660, USA. jparks1@luc.edu
LA  - eng
PT  - Journal Article
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - *Bioethical Issues
MH  - Child
MH  - *Child Care
MH  - Commerce/*ethics
MH  - *Developing Countries
MH  - Female
MH  - Humans
MH  - Infant
MH  - *Internationality
MH  - Medical Tourism/*ethics
MH  - Pregnancy
MH  - *Surrogate Mothers
EDAT- 2010/08/10 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/10 06:00
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - BIOT1831 [pii]
AID - 10.1111/j.1467-8519.2010.01831.x [doi]
PST - ppublish
SO  - Bioethics. 2010 Sep;24(7):333-40. doi: 10.1111/j.1467-8519.2010.01831.x.


PMID- 20690558
OWN - NLM
STAT- MEDLINE
DCOM- 20101022
LR  - 20100809
IS  - 0031-7179 (Print)
IS  - 0031-7179 (Linking)
VI  - 73
IP  - 3
DP  - 2010 Summer
TI  - Re "The ethics of cosmetic enhancement".
PG  - 51
FAU - Smith, Rick J
AU  - Smith RJ
LA  - eng
PT  - Comment
PT  - Letter
PL  - United States
TA  - Pharos Alpha Omega Alpha Honor Med Soc
JT  - The Pharos of Alpha Omega Alpha-Honor Medical Society. Alpha Omega Alpha
JID - 19610620R
SB  - IM
CON - Pharos Alpha Omega Alpha Honor Med Soc. 2010 Winter;73(1):18-23. PMID: 20180290
MH  - Beauty
MH  - Biomedical Enhancement/*ethics
MH  - *Body Image
MH  - *Ethics, Medical
MH  - Europe
MH  - Humans
MH  - *Public Opinion
MH  - Reconstructive Surgical Procedures/*ethics
MH  - Social Desirability
MH  - Social Perception
MH  - Surgery, Plastic/*ethics
MH  - United States
EDAT- 2010/08/10 06:00
MHDA- 2010/10/23 06:00
CRDT- 2010/08/10 06:00
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2010/10/23 06:00 [medline]
PST - ppublish
SO  - Pharos Alpha Omega Alpha Honor Med Soc. 2010 Summer;73(3):51.


PMID- 20690401
OWN - NLM
STAT- MEDLINE
DCOM- 20100928
LR  - 20191210
IS  - 1172-6164 (Print)
IS  - 1172-6156 (Linking)
VI  - 2
IP  - 1
DP  - 2010 Mar
TI  - Validation of quality of life and functional measures for older people for
      telephone administration.
PG  - 35-42
AB  - INTRODUCTION: Quality of life (QoL) and functional status are important aspects
      of health especially for older people. Efficient and valid ways of measuring
      older people's health is of great importance. AIM: This project aims to establish
      the reliability of use of (1) a quality of life measure, the WHOQOL-BREF, and (2)
      a functional measure, the Nottingham Extended Activities of Daily Living scale
      (NEADL), for use over the telephone. METHODS: With ethical approval, patients
      over age 75 years (65 years if Maori) have been enrolled in the BRIGHT trial; a
      randomised controlled trial testing a practice-based screening initiative to
      prevent disability. Participants with possible disability, defined as being
      unable to get in and out of the car or take hot drinks from one room to another, 
      completed a telephone interview including the two measures. Seventy participants 
      repeated the two measures during a face-to-face interview within three months.
      RESULTS: Both WHOQOL-BREF and NEADL scores for the two forms of administration
      produced high Pearson correlation coefficients. There was good agreement for the 
      WHOQOL-BREF as shown by th Bland-Altman graphs; however there was a tendency of a
      greater negative difference the greater the average score became (higher level of
      function) for the NEADL. DISCUSSION: This study shows that telephone interviews
      can generally provide a valid method to assess the quality of life and function
      in older people.
FAU - Lin, Ssu-Yu
AU  - Lin SY
AD  - Department of General Practice and Primary Health Care, School of Population
      Health, The University of Auckland, Auckland, New Zealand.
FAU - Kerse, Ngaire
AU  - Kerse N
FAU - McLean, Christine
AU  - McLean C
FAU - Moyes, Simon A
AU  - Moyes SA
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
PL  - Australia
TA  - J Prim Health Care
JT  - Journal of primary health care
JID - 101524060
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Disability Evaluation
MH  - Female
MH  - *Geriatric Assessment
MH  - Humans
MH  - Male
MH  - *Quality of Life
MH  - Reproducibility of Results
MH  - *Telemedicine
EDAT- 2010/08/10 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/08/10 06:00
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
PST - ppublish
SO  - J Prim Health Care. 2010 Mar;2(1):35-42.


PMID- 20690324
OWN - NLM
STAT- MEDLINE
DCOM- 20100929
LR  - 20190608
IS  - 0027-9684 (Print)
IS  - 0027-9684 (Linking)
VI  - 102
IP  - 7
DP  - 2010 Jul
TI  - Academic medical centers and underserved communities: modern complexities of an
      enduring relationship.
PG  - 605-13
AB  - BACKGROUND: Most private academic medical centers are located in underserved
      areas, yet fiscal pressures have led many to struggle with balancing their
      commitment to surrounding communities with other missions. OBJECTIVE: To explore 
      stakeholders' views regarding the ethical, legal, and financial obligations of
      private academic medical centers to their surrounding neighborhoods. DESIGN,
      PARTICIPANTS, AND MEASURES: QualitatiVe analysis of key informant interviews
      during 2008 with medical students, faculty and community physicians,
      administrators, and community health leaders at a large urban academic medical
      center. Grounded theory was used to iteratively review, code, and revise a
      taxonomy of themes, with abstraction of illustrative quotes. RESULTS: Nineteen
      in-depth interviews were conducted. All respondents believed academic medical
      centers have an obligation to their surrounding communities but characterized the
      extent of this obigation in a variety of ways. Respondents disagreed about how
      the core mission of an academic center should be defined, although many
      recognized the tripartite mission, conflict centered on the balance that should
      be sought between research and clinical care. A majority of interviewees
      expressed frustration with the nation's current health care system. Many provided
      unprompted recommendations regarding how academic medical centers might engage
      their underserved communities, including conducting formal needs analyses,
      promoting ongoing dialogue, and using information technology to bridge the
      provision of clinical care in community and academic settings. CONCLUSIONS: These
      data provide enriching perspectives from stakeholders regarding this enduring yet
      evolving relationship. The diversity of views illustrates one of the challenges
      that will accompany health care reform impacting academic medical centers and
      their surrounding, often underserved, communities.
FAU - Lale, Allison
AU  - Lale A
AD  - Pritzker School of Medicine, The University of Chicago, IL 60637, USA.
FAU - Moloney, Rachael
AU  - Moloney R
FAU - Alexander, G Caleb
AU  - Alexander GC
LA  - eng
GR  - K08 HS15699-01A1/HS/AHRQ HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Natl Med Assoc
JT  - Journal of the National Medical Association
JID - 7503090
SB  - IM
MH  - *Academic Medical Centers
MH  - Adult
MH  - Aged
MH  - Attitude to Health
MH  - *Community-Institutional Relations
MH  - Female
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Medically Underserved Area
MH  - Middle Aged
MH  - United States
MH  - Urban Population
EDAT- 2010/08/10 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/08/10 06:00
PHST- 2010/08/10 06:00 [entrez]
PHST- 2010/08/10 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - S0027-9684(15)30638-6 [pii]
AID - 10.1016/s0027-9684(15)30638-6 [doi]
PST - ppublish
SO  - J Natl Med Assoc. 2010 Jul;102(7):605-13. doi: 10.1016/s0027-9684(15)30638-6.


PMID- 20689927
OWN - NLM
STAT- MEDLINE
DCOM- 20110222
LR  - 20211020
IS  - 1432-1238 (Electronic)
IS  - 0342-4642 (Linking)
VI  - 36
IP  - 11
DP  - 2010 Nov
TI  - Reorganising the pandemic triage processes to ethically maximise individuals'
      best interests.
PG  - 1966-71
LID - 10.1007/s00134-010-1986-2 [doi]
AB  - PURPOSE: To provide a revised definition, process and purpose of triage to
      maximise the number of patients receiving intensive care during a crisis.
      METHODS: Based on the ethical principle of virtue ethics and the underlying goal 
      of providing individual patients with treatment according to their best
      interests, the methodology of triage is reassessed and revised. RESULTS: The
      decision making processes regarding treatment decisions during a pandemic are
      redefined and new methods of intensive care provision recommended as well as
      recommending the use of a 'ranking' system for patients excluded from intensive
      care, defining the role of non-intensive care specialists, and applying two types
      of triage as 'organisational triage' and 'treatment triage' based on the demand
      for intensive care. CONCLUSION: Using a different underlying ethical basis upon
      which to plan for a pandemic crisis could maximise the number of patients
      receiving intensive care based on individual patients' best interests.
FAU - Tillyard, Andrew
AU  - Tillyard A
AD  - Derriford Hospital, Plymouth, UK. andrew.tillyard@phnt.swest.nhs.uk
LA  - eng
PT  - Journal Article
DEP - 20100806
PL  - United States
TA  - Intensive Care Med
JT  - Intensive care medicine
JID - 7704851
SB  - IM
MH  - Delivery of Health Care/*ethics/standards
MH  - Emergency Service, Hospital
MH  - Humans
MH  - *Pandemics
MH  - Triage/ethics/*organization & administration/standards
EDAT- 2010/08/07 06:00
MHDA- 2011/02/23 06:00
CRDT- 2010/08/07 06:00
PHST- 2009/12/23 00:00 [received]
PHST- 2010/07/08 00:00 [accepted]
PHST- 2010/08/07 06:00 [entrez]
PHST- 2010/08/07 06:00 [pubmed]
PHST- 2011/02/23 06:00 [medline]
AID - 10.1007/s00134-010-1986-2 [doi]
PST - ppublish
SO  - Intensive Care Med. 2010 Nov;36(11):1966-71. doi: 10.1007/s00134-010-1986-2. Epub
      2010 Aug 6.


PMID- 20689248
OWN - NLM
STAT- MEDLINE
DCOM- 20111027
LR  - 20211020
IS  - 1662-8063 (Electronic)
IS  - 1662-4246 (Linking)
VI  - 14
IP  - 4-5
DP  - 2011
TI  - Parental attitudes toward ethical and social issues surrounding the expansion of 
      newborn screening using new technologies.
PG  - 298-306
LID - 10.1159/000314644 [doi]
AB  - AIMS: This study assessed parent knowledge of newborn screening (NBS) and parent 
      attitudes toward NBS for untreatable conditions, NBS for late-onset disorders and
      informed consent in NBS. METHODS: Seventeen qualitative focus groups were held in
      Alaska, California, Hawaii, and Washington with mothers of children 10 years old 
      or younger. RESULTS: Most participants did not recall receiving information about
      NBS, and all wanted this information prenatally. In addition, most felt that the 
      current system of 'informed dissent' was adequate, provided they were told about 
      NBS prior to delivery. All women supported NBS for conditions that occur in
      infancy without a proven treatment. However, they disagreed about NBS for
      disorders that manifest in late childhood or adulthood. CONCLUSIONS: The results 
      show a general consensus among the focus group participants about issues that
      cause dissent among public health and health care professionals. Parent attitudes
      differ from those of many professional communities with regard to timing of NBS
      education, informed consent, NBS for disorders that lack an effective treatment, 
      and predictive testing of children for late-onset disorders. The results
      highlight the need to further research parent opinions about expanded NBS using
      new technologies and to include parents in the development of NBS policies.
CI  - Copyright (c) 2010 S. Karger AG, Basel.
FAU - Hasegawa, L E
AU  - Hasegawa LE
AD  - Hawaii Genetics Program, Children with Special Needs Branch, Hawaii Department of
      Health, Honolulu, Hawaii 96816, USA. ianne@hawaiigenetics.org
FAU - Fergus, K A
AU  - Fergus KA
FAU - Ojeda, N
AU  - Ojeda N
FAU - Au, S M
AU  - Au SM
LA  - eng
GR  - 1 H46 MC 00189-03/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100730
PL  - Switzerland
TA  - Public Health Genomics
JT  - Public health genomics
JID - 101474167
SB  - IM
MH  - Adult
MH  - *Attitude to Health
MH  - *Ethics
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Middle Aged
MH  - Neonatal Screening/*psychology
MH  - Parents/*psychology
PMC - PMC3214890
EDAT- 2010/08/07 06:00
MHDA- 2011/10/28 06:00
CRDT- 2010/08/07 06:00
PHST- 2010/08/07 06:00 [entrez]
PHST- 2010/08/07 06:00 [pubmed]
PHST- 2011/10/28 06:00 [medline]
AID - 000314644 [pii]
AID - 10.1159/000314644 [doi]
PST - ppublish
SO  - Public Health Genomics. 2011;14(4-5):298-306. doi: 10.1159/000314644. Epub 2010
      Jul 30.


PMID- 20689052
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20100806
IS  - 1524-8399 (Print)
IS  - 1524-8399 (Linking)
VI  - 11
IP  - 4
DP  - 2010 Jul
TI  - The health disparities industry: is it an ethical conundrum?
PG  - 454-64
LID - 10.1177/1524839910375612 [doi]
AB  - Reducing health disparities is the purported mission of a huge network of
      professionals representing many specialties and organizations offering a variety 
      of products and services. Given its elaborate infrastructure and specialized set 
      of activities, we identity the network as the health disparities industry. In
      this article, we question the ethics of this industry. Specifically, we ask
      whether the public mission is trumped by questionable industry leadership,
      ethics, and quality assurances. Drawing on general principles of ethics and
      differentiating ethical concerns from ethical problems, we conclude that the
      collective behaviors within the industry may represent an ethical conundrum. The 
      article concludes with a call for the cross-examination of the industry
      practices.
FAU - Shaw-Ridley, Mary
AU  - Shaw-Ridley M
AD  - Center for the Study of Health Disparities, Department of Health & Kinesiology,
      Texas A&M University, College Station, Texas, USA. mdshaw@hlkn.tamu.edu
FAU - Ridley, Charles R
AU  - Ridley CR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Health Promot Pract
JT  - Health promotion practice
JID - 100890609
SB  - IM
MH  - Health Services Research/*ethics/*organization & administration
MH  - *Health Status Disparities
MH  - Healthcare Disparities/*ethics
MH  - Humans
MH  - Minority Health/*ethics
EDAT- 2010/08/07 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/08/07 06:00
PHST- 2010/08/07 06:00 [entrez]
PHST- 2010/08/07 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - 11/4/454 [pii]
AID - 10.1177/1524839910375612 [doi]
PST - ppublish
SO  - Health Promot Pract. 2010 Jul;11(4):454-64. doi: 10.1177/1524839910375612.


PMID- 20688783
OWN - NLM
STAT- MEDLINE
DCOM- 20110621
LR  - 20110224
IS  - 1741-3850 (Electronic)
IS  - 1741-3842 (Linking)
VI  - 33
IP  - 1
DP  - 2011 Mar
TI  - The perceived sexual health needs of looked after young people: findings from a
      qualitative study led through a partnership between public health and health
      psychology.
PG  - 86-92
LID - 10.1093/pubmed/fdq055 [doi]
AB  - BACKGROUND: Looked after young people (LAYP) have poorer sexual health outcomes
      than their peers. However, research seldom examines the health needs of, or
      intervenes with, this group. The aim of the current study was to identify LAYP's 
      perceived sexual health needs and explore sources of sexual health information,
      knowledge levels, concerns and service preferences. METHODS: Looked after young
      people within Fife, Scotland, were recruited through their workers and carers to 
      participate in qualitative semi-structured interviews. Those aged 12-19 years
      were targeted for recruitment. National Health Services ethics approval was
      granted. Thematic analysis was conducted using NVivo. RESULTS: Interviews were
      conducted with 10 LAYP. Key themes included gaps in knowledge, and gaps between
      knowledge and behaviour. Being 'looked after' may have negative consequences on
      knowledge, sources of support and safer sex. A flexible, one-to-one service,
      aimed at several lifestyle issues, not solely sexual health, was preferred by
      respondents. CONCLUSION: Looked after young people require support to bridge the 
      gap between knowledge and behaviour and several theories relevant to the findings
      have been identified. Participants desired more support around a range of health 
      issues, which may come from school, workers and carers, as well as health
      professionals. Further research examining effective interventions with this group
      is crucial to improve outcomes.
FAU - Dale, H
AU  - Dale H
AD  - NHS Fife, Department of Psychology, Stratheden Hospital, Cupar, Fife, UK.
      hannahdale@nhs.net
FAU - Watson, L
AU  - Watson L
FAU - Adair, P
AU  - Adair P
FAU - Moy, M
AU  - Moy M
FAU - Humphris, G
AU  - Humphris G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100805
PL  - England
TA  - J Public Health (Oxf)
JT  - Journal of public health (Oxford, England)
JID - 101188638
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Behavioral Medicine/*methods
MH  - Cooperative Behavior
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - Health Promotion/methods
MH  - *Health Services Needs and Demand
MH  - Humans
MH  - Life Style
MH  - Male
MH  - Public Health/*methods
MH  - Qualitative Research
MH  - *Sexuality
MH  - *Social Perception
MH  - Tape Recording
MH  - Young Adult
EDAT- 2010/08/07 06:00
MHDA- 2011/06/22 06:00
CRDT- 2010/08/07 06:00
PHST- 2010/08/07 06:00 [entrez]
PHST- 2010/08/07 06:00 [pubmed]
PHST- 2011/06/22 06:00 [medline]
AID - fdq055 [pii]
AID - 10.1093/pubmed/fdq055 [doi]
PST - ppublish
SO  - J Public Health (Oxf). 2011 Mar;33(1):86-92. doi: 10.1093/pubmed/fdq055. Epub
      2010 Aug 5.


PMID- 20687819
OWN - NLM
STAT- MEDLINE
DCOM- 20101210
LR  - 20161125
IS  - 1557-9034 (Electronic)
IS  - 1092-6429 (Linking)
VI  - 20
IP  - 6
DP  - 2010 Jul-Aug
TI  - Nonoperative closure of persistent gastrocutaneous fistulas in children with
      2-octylcyanoacrylate.
PG  - 565-7
LID - 10.1089/lap.2009.0441 [doi]
AB  - UNLABELLED: A persistent gastrocutaneous fistula (pGCF) is an all-too-common
      complication following removal of a gastrostomy tube (GT) in a child and is
      associated with significant morbidity. The most common initial methods to manage 
      pGCF include local would care and occlusion techniques. Failure of this approach 
      is followed by surgical excision of the fistula tract and closure of the
      gastrostomy under general anesthesia. We report the first use of a tissue
      adhesive, 2-octylcyanoacrylate (2OC) (Dermabond; Ethicon, Sommerville, NJ) as a
      non-surgical method to close pGCF in children. METHODS: The families of children 
      presenting to the pediatric surgical division for management of a pGCF were
      offered the option of 2OC closure. Children not receiving or who failed to
      achieve closure with 2OC therapy underwent surgery for excision of the pGCF with 
      primary closure of the stomach and soft tissues. RESULTS: Seven children
      underwent 2OC therapy. 57% (4 of 7) of the children had complete closure of the
      pGCF with 2OC therapy. Three children underwent operative closure without
      complication. CONCLUSIONS: The tissue adhesive 2OC can successfully close a pGCF 
      in children after GT removal. This therapy is cost-effective, non-invasive, does 
      not require general anesthesia, and can be performed in an outpatient setting.
FAU - Lukish, Jeffrey
AU  - Lukish J
AD  - Division of Pediatric Surgery, Department of Surgery, The Johns Hopkins
      University, Baltimore, Maryland 21287, USA. jlukish@jhu.edu
FAU - Marmon, Louis
AU  - Marmon L
FAU - Burns, Christopher
AU  - Burns C
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Laparoendosc Adv Surg Tech A
JT  - Journal of laparoendoscopic & advanced surgical techniques. Part A
JID - 9706293
RN  - 0 (Cyanoacrylates)
RN  - 0 (Tissue Adhesives)
RN  - 6C655P1XVG (octyl 2-cyanoacrylate)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Cutaneous Fistula/*therapy
MH  - Cyanoacrylates/*therapeutic use
MH  - Device Removal/adverse effects
MH  - Gastric Fistula/*therapy
MH  - Gastrostomy/adverse effects
MH  - Humans
MH  - Infant
MH  - Tissue Adhesives/*therapeutic use
EDAT- 2010/08/07 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/07 06:00
PHST- 2010/08/07 06:00 [entrez]
PHST- 2010/08/07 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1089/lap.2009.0441 [doi]
PST - ppublish
SO  - J Laparoendosc Adv Surg Tech A. 2010 Jul-Aug;20(6):565-7. doi:
      10.1089/lap.2009.0441.


PMID- 20687186
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20100805
IS  - 1931-7581 (Electronic)
IS  - 0027-2507 (Linking)
VI  - 77
IP  - 4
DP  - 2010 Jul-Aug
TI  - Joseph's wishes: ethical decision-making in Duchenne muscular dystrophy.
PG  - 394-7
LID - 10.1002/msj.20196 [doi]
AB  - The death of a child is an uncommon occurrence and can be difficult for families 
      to accept. Attempts by the healthcare team to discuss end-of-life issues can be
      so upsetting to families that they refuse to participate in the discussion. Even 
      with diseases where an early death can be anticipated, such as Duchenne muscular 
      dystrophy, the family is often reluctant to discuss end-of-life issues when the
      patient is relatively healthy, preferring to focus on the current health issues. 
      In this article we discuss what happens when there are disagreements between the 
      patient and family and the needs of both must be taken into consideration.
CI  - 2010 Mount Sinai School of Medicine.
FAU - Penner, Leigh
AU  - Penner L
AD  - Mount Sinai Kravis Children's Hospital, New York, NY, USA.
      leigh.penner@mountsinai.org
FAU - Cantor, Rabbi Mollie
AU  - Cantor RM
FAU - Siegel, Linda
AU  - Siegel L
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Mt Sinai J Med
JT  - The Mount Sinai journal of medicine, New York
JID - 0241032
SB  - IM
MH  - Communication
MH  - Decision Making/*ethics
MH  - *Ethics, Medical
MH  - Fatal Outcome
MH  - Humans
MH  - Male
MH  - *Muscular Dystrophy, Duchenne
MH  - Palliative Care/*ethics
MH  - *Patient Satisfaction
MH  - Physician-Patient Relations
MH  - Young Adult
EDAT- 2010/08/06 06:00
MHDA- 2011/06/03 06:00
CRDT- 2010/08/06 06:00
PHST- 2010/08/06 06:00 [entrez]
PHST- 2010/08/06 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
AID - 10.1002/msj.20196 [doi]
PST - ppublish
SO  - Mt Sinai J Med. 2010 Jul-Aug;77(4):394-7. doi: 10.1002/msj.20196.


PMID- 20687036
OWN - NLM
STAT- MEDLINE
DCOM- 20101018
LR  - 20100805
IS  - 1012-5302 (Print)
IS  - 1012-5302 (Linking)
VI  - 23
IP  - 4
DP  - 2010 Aug
TI  - [Autonomy in the nursing home--conceptual considerations regarding
      self-determination and capacity to act on the basis of a model].
PG  - 240-8
LID - 10.1024/1012-5302/a000051 [doi]
AB  - Autonomy is an exceptionally complex philosophical concept which is present in
      ethical considerations in health care settings. Currently, no consistent
      definition of autonomy exists. From the perspective of the authors,
      self-determination and capacity to act independently are essential aspects of
      autonomy. While there are limited general results regarding autonomy in old age, 
      autonomy of nursing home residents and the corresponding critical influence
      factors still lack in-depth examination. The aim of this article is to contribute
      to a more thorough understanding of autonomy of nursing home residents. Due to
      the high percentage of residents with cognitive impairment, this population plays
      a crucial role regarding the conceptualisation of autonomy. Various approaches
      combined with the perspectives developed by the interdisciplinary PAiN-Project
      team (Pain and Autonomy in the Nursing Home), led to the formulation of a novel
      conceptualisation of autonomy. Based on theoretical and discursive
      considerations, the model "Determination Factors of Autonomy" focuses on the
      residents' self-determination and ability to perform activities of daily living
      in the nursing home context. According to the author's conceptualisation,
      autonomy occurs in various ranges in regard to self-awareness as well as the
      appreciation of autonomy by others.
FAU - Wulff, Ines
AU  - Wulff I
AD  - Institut fur Medizinische Soziologie, Charite-Universitatsmedizin Berlin.
      Ines.Wulff@charite.de
FAU - Kalinowski, Sonja
AU  - Kalinowski S
FAU - Drager, Dagmar
AU  - Drager D
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Autonomie im Pflegeheim--Konzeptionelle Uberlegungen zu Selbstbestimmung und
      Handlungsfahigkeit anhand eines Modells.
PL  - Switzerland
TA  - Pflege
JT  - Pflege
JID - 8907069
MH  - Aged
MH  - Aged, 80 and over
MH  - Germany
MH  - *Homes for the Aged
MH  - Humans
MH  - *Mental Competency
MH  - *Models, Nursing
MH  - *Nursing Homes
MH  - *Personal Autonomy
EDAT- 2010/08/06 06:00
MHDA- 2010/10/19 06:00
CRDT- 2010/08/06 06:00
PHST- 2010/08/06 06:00 [entrez]
PHST- 2010/08/06 06:00 [pubmed]
PHST- 2010/10/19 06:00 [medline]
AID - 10.1024/1012-5302/a000051 [doi]
PST - ppublish
SO  - Pflege. 2010 Aug;23(4):240-8. doi: 10.1024/1012-5302/a000051.


PMID- 20686331
OWN - NLM
STAT- MEDLINE
DCOM- 20110209
LR  - 20190911
IS  - 1880-3989 (Electronic)
IS  - 0388-1350 (Linking)
VI  - 35
IP  - 4
DP  - 2010 Aug
TI  - Pharmacological assessment of ARTCEREB irrigation and perfusion solution for
      cerebrospinal surgery using primary cultures of rat brain cells.
PG  - 447-57
AB  - ARTCEREB irrigation and perfusion solution (Artcereb), an ethical pharmaceutical,
      is typically applied inside the skull and spinal cavity as artificial fluid.
      Artcereb is composed of glucose and electrolytes (Na+, K+, Mg2+, Ca2+, Cl-, HCO3-
      and P) and has a pH of 7.3. An in vitro assessment of the effects of Artcereb on 
      cell culture of rat fetal astrocytes or rat fetal brain cells was performed in
      comparison with normal saline and lactated Ringer's solutions. Furthermore, the
      effects of Artcereb on cell culture of rat fetal brain cells were also assessed
      in comparison with Krebs bicarbonate solution. Cell function after exposure to
      Artcereb was assessed based on 3H-thymidine incorporation activity. Cell function
      after exposure to Artcereb and lactated Ringer's solution in primary cultures of 
      rat fetal astrocytes remained unaffected when compared to that after exposure to 
      normal saline. Cell function after exposure to Artcereb in a primary culture of
      rat brain cells remained unaffected as compared to that after exposure to normal 
      saline and lactated Ringer's solution. However, function decreased after exposure
      to a modified Artcereb formulation lacking bicarbonate, thus confirming that the 
      presence of bicarbonate is essential for the Artcereb formulation.
FAU - Nishimura, Masuhiro
AU  - Nishimura M
AD  - Research and Development Center, Otsuka Pharmaceutical Factory, Inc., Tokushima, 
      Japan. Nishimura.Masuhiro@otsuka.jp
FAU - Doi, Kazuhisa
AU  - Doi K
FAU - Kishimoto, Sanae
AU  - Kishimoto S
FAU - Koshitani, Osamu
AU  - Koshitani O
FAU - Naito, Shinsaku
AU  - Naito S
FAU - Yamauchi, Aiko
AU  - Yamauchi A
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - J Toxicol Sci
JT  - The Journal of toxicological sciences
JID - 7805798
RN  - 0 (Bicarbonates)
RN  - 0 (Electrolytes)
RN  - 0 (Pharmaceutical Solutions)
RN  - 0 (Solutions)
RN  - 451W47IQ8X (Sodium Chloride)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Animals
MH  - Astrocytes/*drug effects
MH  - Bicarbonates/pharmacology
MH  - Brain/*drug effects/embryology/surgery
MH  - Cell Culture Techniques
MH  - Cerebrospinal Fluid/*chemistry
MH  - Electrolytes/pharmacology
MH  - Female
MH  - Fetus
MH  - Glucose/pharmacology
MH  - Perfusion
MH  - Pharmaceutical Solutions/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sodium Chloride/pharmacology
MH  - Solutions
MH  - Therapeutic Irrigation
EDAT- 2010/08/06 06:00
MHDA- 2011/02/10 06:00
CRDT- 2010/08/06 06:00
PHST- 2010/08/06 06:00 [entrez]
PHST- 2010/08/06 06:00 [pubmed]
PHST- 2011/02/10 06:00 [medline]
AID - JST.JSTAGE/jts/35.447 [pii]
AID - 10.2131/jts.35.447 [doi]
PST - ppublish
SO  - J Toxicol Sci. 2010 Aug;35(4):447-57. doi: 10.2131/jts.35.447.


PMID- 20686245
OWN - NLM
STAT- MEDLINE
DCOM- 20101214
LR  - 20190720
IS  - 1347-5215 (Electronic)
IS  - 0918-6158 (Linking)
VI  - 33
IP  - 8
DP  - 2010
TI  - The ethical Kampo formulation Sho-seiryu-to (TJ-19) prevents bleomycin-induced
      pulmonary fibrosis in rats.
PG  - 1438-42
AB  - The effects of Sho-seiryu-to (TJ-19), an ethical Kampo formulation, on bleomycin 
      (BLM)-induced pulmonary fibrosis in rats was examined. Pulmonary fibrosis was
      induced by intratracheal instillation of a single dose of BLM (5 mg/kg). The
      TJ-19 used consisted of at least 21 constituents, as determined by
      three-dimensional HPLC analysis, and was administered orally twice a day at a
      dose of 1.5 g/kg until the end of the study period. Changes in general appearance
      and body weight were monitored. Twenty-eight days after BLM instillation, the
      animals were sacrificed and the study parameters were measured. TJ-19 attenuated 
      the loss in body weight, increase in lung/body weight ratio and concentration of 
      hydroxyproline and malondialdehyde in the lung tissues induced by BLM
      administration. TJ-19 also prevented BLM-induced fibrotic changes in the lung
      histology. These protective effects of TJ-19 were observed when administration
      was started 1 week before and simultaneously with the instillation of BLM. These 
      results suggest that TJ-19 has prophylactic potential against BLM-induced
      pulmonary fibrosis, and may therefore be a promising drug candidate and medicinal
      resource for preventing BLM-induced and idiopathic pulmonary fibrosis.
FAU - Yang, Chang-qing
AU  - Yang CQ
AD  - Department of Pharmaceutical Sciences, College of Pharmacy, Yanbian University,
      Jilin Prov., Yanji 133000, China.
FAU - Sun, Peng-yuan
AU  - Sun PY
FAU - Ding, Da-zhi
AU  - Ding DZ
FAU - Moriuchi, Hiroshi
AU  - Moriuchi H
FAU - Ishitsuka, Yoichi
AU  - Ishitsuka Y
FAU - Irikura, Mitsuru
AU  - Irikura M
FAU - Irie, Tetsumi
AU  - Irie T
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Lipid Peroxides)
RN  - 0 (sho-seiryu-to)
RN  - 11056-06-7 (Bleomycin)
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Animals
MH  - Bleomycin
MH  - Chromatography, High Pressure Liquid
MH  - Collagen/metabolism
MH  - Disease Models, Animal
MH  - Drugs, Chinese Herbal/administration & dosage/*therapeutic use
MH  - Idiopathic Pulmonary Fibrosis/chemically induced/metabolism/pathology/*prevention
      & control
MH  - Lipid Peroxidation/drug effects
MH  - Lipid Peroxides/metabolism
MH  - Lung/*drug effects/metabolism/pathology
MH  - Male
MH  - *Medicine, Kampo
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2010/08/06 06:00
MHDA- 2010/12/16 06:00
CRDT- 2010/08/06 06:00
PHST- 2010/08/06 06:00 [entrez]
PHST- 2010/08/06 06:00 [pubmed]
PHST- 2010/12/16 06:00 [medline]
AID - JST.JSTAGE/bpb/33.1438 [pii]
AID - 10.1248/bpb.33.1438 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2010;33(8):1438-42. doi: 10.1248/bpb.33.1438.


PMID- 20686211
OWN - NLM
STAT- MEDLINE
DCOM- 20101007
LR  - 20190724
IS  - 0031-6903 (Print)
IS  - 0031-6903 (Linking)
VI  - 130
IP  - 8
DP  - 2010 Aug
TI  - [Development of alternative to animal experiment in evaluation of skin irritation
      caused by alcohol-based hand rubs].
PG  - 1069-73
AB  - Alcohol-based hand rubs are widely used for infection control in clinical
      practice. However, it is known that frequent use of the alcohol-based hand rubs
      may cause skin irritation. To predict the skin irritation in human, animal
      experiments are quite useful. Especially, the Draize Test using rabbits is
      suitable for this purpose because their skin is highly sensitive. On the other
      hand, the development of alternative to animal experiments is important not only 
      from the viewpoint of ethical aspects but also from the efficient research and
      development. Reconstructed human epidermis (RhE) was developed as a human skin
      equivalent model in vitro, and has been applied to the evaluation of skin
      irritation. But the RhE has not been utilized for the evaluation of alcohol-based
      hand rubs because of the high skin permeability and cytotoxicity of alcohols. The
      aim of this study was to develop a new method using the RhE in evaluation of skin
      irritation caused by alcohol-based hand rubs. The authors propose an experimental
      technique named "Skin model blowing method (SMBM)" consisting of the sequential
      procedure as follows; applying small amount of testing sample on RhE, blow-dry,
      post incubation, and cell viability measurement. According to the SMBM, the skin 
      irritation caused by alcohol-based hand rubs could be evaluated under the similar
      condition of their actual use. It was found that a high correlation existed
      between the cell viability obtained from SMBM and the skin irritation index in
      rabbit which had been reported previously.
FAU - Yamamoto, Nobuyuki
AU  - Yamamoto N
AD  - NOF CORPORATION, Tsukuba Corporate Research Laboratory, Tsukuba, Ibaraki, Japan. 
      nobuyuki_yamamoto@nof.co.jp
FAU - Miyamoto, Koji
AU  - Miyamoto K
FAU - Katoh, Masakazu
AU  - Katoh M
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Yakugaku Zasshi
JT  - Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
JID - 0413613
RN  - 0 (Anti-Infective Agents, Local)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Animal Testing Alternatives/*methods
MH  - Animals
MH  - Anti-Infective Agents, Local/*adverse effects
MH  - Cell Survival/drug effects
MH  - Epidermal Cells
MH  - Epidermis/drug effects
MH  - Ethanol/*adverse effects
MH  - Hand Disinfection
MH  - Humans
MH  - Rabbits
MH  - Skin Irritancy Tests/*methods
EDAT- 2010/08/06 06:00
MHDA- 2010/10/12 06:00
CRDT- 2010/08/06 06:00
PHST- 2010/08/06 06:00 [entrez]
PHST- 2010/08/06 06:00 [pubmed]
PHST- 2010/10/12 06:00 [medline]
AID - JST.JSTAGE/yakushi/130.1069 [pii]
AID - 10.1248/yakushi.130.1069 [doi]
PST - ppublish
SO  - Yakugaku Zasshi. 2010 Aug;130(8):1069-73. doi: 10.1248/yakushi.130.1069.


PMID- 20685558
OWN - NLM
STAT- MEDLINE
DCOM- 20101206
LR  - 20100805
IS  - 1558-0474 (Electronic)
IS  - 0889-8545 (Linking)
VI  - 37
IP  - 2
DP  - 2010 Jun
TI  - Ethical issues in obstetrics.
PG  - 345-57
LID - 10.1016/j.ogc.2010.02.005 [doi]
AB  - Obstetricians must become comfortable addressing the ethical issues involved in
      clinical obstetrics and therefore must have an understanding of the key elements 
      of clinical medical ethics. Balancing the principles of medical ethics can guide 
      clinicians toward solutions to ethical dilemmas encountered in the care of
      pregnant women. The purpose of this article is to review the ethical foundations 
      of clinical practice, recognize the ethical issues obstetricians face every day
      in caring for patients, and facilitate decision making. This article discusses
      the relevant ethical principles, identifies unique features of obstetrical
      ethics, examines ethical principles as they apply to pregnant patient and her
      fetus, and thereby, provides a conceptual framework for considering ethical
      issues and facilitating decision making in clinical obstetrics.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Digiovanni, Laura M
AU  - Digiovanni LM
AD  - The Fetal Center, University of Chicago, 5841 South Maryland Avenue, MC 2050,
      Chicago, IL 60637, USA. ldigiovanni@uchicago.edu
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Obstet Gynecol Clin North Am
JT  - Obstetrics and gynecology clinics of North America
JID - 8709551
SB  - IM
MH  - Advance Directives
MH  - Beneficence
MH  - *Ethics, Medical
MH  - Female
MH  - Fetus
MH  - Humans
MH  - Informed Consent
MH  - Medical Futility
MH  - Obstetrics/*ethics
MH  - Physician-Patient Relations
MH  - Pre-Eclampsia/diagnosis
MH  - Pregnancy
MH  - Treatment Refusal/ethics/legislation & jurisprudence
EDAT- 2010/08/06 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/06 06:00
PHST- 2010/08/06 06:00 [entrez]
PHST- 2010/08/06 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S0889-8545(10)00009-4 [pii]
AID - 10.1016/j.ogc.2010.02.005 [doi]
PST - ppublish
SO  - Obstet Gynecol Clin North Am. 2010 Jun;37(2):345-57. doi:
      10.1016/j.ogc.2010.02.005.


PMID- 20685395
OWN - NLM
STAT- MEDLINE
DCOM- 20110131
LR  - 20101005
IS  - 1873-488X (Electronic)
IS  - 1056-8719 (Linking)
VI  - 62
IP  - 3
DP  - 2010 Nov-Dec
TI  - The RETHINK project--minipigs as models for the toxicity testing of new medicines
      and chemicals: an impact assessment.
PG  - 158-9
LID - 10.1016/j.vascn.2010.05.003 [doi]
AB  - The objective of the RETHINK project was to evaluate the potential impact of
      toxicity testing in the minipig as an alternative approach in regulatory toxicity
      testing that can contribute to the replacement, refinement and reduction of
      animal testing (3Rs). Minipigs are strains of domestic pigs that are markedly
      smaller than farmyard varieties, and thus better adapted to laboratory housing.
      The pig closely resembles man in many features of its anatomy, physiology,
      biochemistry and lifestyle. In particular, the cardio-vascular system, skin and
      digestive tract are considered to be very good models for man. Because of these
      similarities the toxic effects of chemicals and drugs in pigs may resemble the
      effects in man more closely than do some other commonly used laboratory animals. 
      The pig also has some features that make it a very practical model for laboratory
      studies. Finally, being a food animal, testing in the minipig may be more
      acceptable to the public than animals such as dogs or monkeys. Expert study
      groups (Working Groups) were assembled to review five different areas relating to
      the use of minipigs in regulatory safety testing: ethical issues, welfare and
      animal care, development of new medicines and chemicals, safety testing issues
      and emerging technologies in safety testing. Their conclusions are presented in
      the articles of this special issue. The RETHINK project was funded as a Specific 
      Support Action under the European Community 6th Framework Programme.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Forster, Roy
AU  - Forster R
AD  - CIT, BP 563, 27000 Evreux, France. roy.forster@citox.com
FAU - Bode, Gerd
AU  - Bode G
FAU - Ellegaard, Lars
AU  - Ellegaard L
FAU - van der Laan, Jan Willem
AU  - van der Laan JW
CN  - Steering Group of the RETHINK Project
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100601
PL  - United States
TA  - J Pharmacol Toxicol Methods
JT  - Journal of pharmacological and toxicological methods
JID - 9206091
RN  - 0 (Xenobiotics)
SB  - IM
MH  - Animal Use Alternatives
MH  - Animal Welfare
MH  - Animals
MH  - European Union
MH  - Government Regulation
MH  - *Models, Animal
MH  - Swine
MH  - *Swine, Miniature/physiology
MH  - *Toxicity Tests/ethics/standards
MH  - Xenobiotics/*toxicity
IR  - Forster R
FIR - Forster, Roy
IR  - Bode G
FIR - Bode, Gerd
IR  - Ellegaard L
FIR - Ellegaard, Lars
IR  - van der Laan JW
FIR - van der Laan, Jan Willem
EDAT- 2010/08/06 06:00
MHDA- 2011/02/01 06:00
CRDT- 2010/08/06 06:00
PHST- 2009/12/30 00:00 [received]
PHST- 2010/05/21 00:00 [revised]
PHST- 2010/05/24 00:00 [accepted]
PHST- 2010/08/06 06:00 [entrez]
PHST- 2010/08/06 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
AID - S1056-8719(10)00076-6 [pii]
AID - 10.1016/j.vascn.2010.05.003 [doi]
PST - ppublish
SO  - J Pharmacol Toxicol Methods. 2010 Nov-Dec;62(3):158-9. doi:
      10.1016/j.vascn.2010.05.003. Epub 2010 Jun 1.


PMID- 20685309
OWN - NLM
STAT- MEDLINE
DCOM- 20110131
LR  - 20101005
IS  - 1873-488X (Electronic)
IS  - 1056-8719 (Linking)
VI  - 62
IP  - 3
DP  - 2010 Nov-Dec
TI  - The RETHINK project on minipigs in the toxicity testing of new medicines and
      chemicals: conclusions and recommendations.
PG  - 236-42
LID - 10.1016/j.vascn.2010.05.008 [doi]
AB  - The objective of the RETHINK project was to evaluate the potential impact of
      toxicity testing in the minipig as an alternative approach in regulatory toxicity
      testing that can contribute to the replacement, refinement and reduction of
      animal testing (3Rs). Expert study groups (Working Groups) were assembled to
      review five different areas relating to the use of minipigs in regulatory safety 
      testing: ethical issues, welfare and animal care, development of new medicines
      and chemicals, safety testing issues and emerging technologies in safety testing.
      The conclusions and recommendations of the projects are presented in this
      article. It is concluded that there are no specific areas where restrictions to
      the use of minipigs in toxicology are required for welfare reasons. The minipig
      model is generally acceptable to regulatory authorities, provided it is
      adequately justified. The minipig is an interesting model for safety testing
      since there are numerous anatomical, physiological, genetic and biochemical
      similarities to humans. In addition many features of the minipig make it a
      practical and flexible model for safety testing. The use of the minipig in
      development of products does not bring any financial penalty in terms of the cost
      of testing. Benefits in terms of 3Rs can be identified in terms of life-cycle
      analysis of the use of minipigs compared to dogs and non-human primates. Finally 
      the minipig (unlike the dog) is well positioned to take advantage of genomics and
      gene manipulation technologies. Specific recommendations for further research are
      made, which could bring 3Rs benefits. To deploy the minipig to the best
      advantage, clear information is needed about the predictivity of the minipig for 
      human toxicities, and focussed action to define the potential role of the minipig
      in testing of biologics.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Forster, Roy
AU  - Forster R
AD  - CIT, BP 563, 27000 Evreux, France. roy.forster@citox.com
FAU - Bode, Gerd
AU  - Bode G
FAU - Ellegaard, Lars
AU  - Ellegaard L
FAU - van der Laan, Jan-Willem
AU  - van der Laan JW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100531
PL  - United States
TA  - J Pharmacol Toxicol Methods
JT  - Journal of pharmacological and toxicological methods
JID - 9206091
RN  - 0 (Xenobiotics)
SB  - IM
MH  - Animal Use Alternatives
MH  - Animal Welfare
MH  - Animals
MH  - European Union
MH  - Government Regulation
MH  - Humans
MH  - *Models, Animal
MH  - Research Design
MH  - Swine
MH  - *Swine, Miniature/physiology
MH  - *Toxicity Tests/economics/ethics/standards
MH  - Xenobiotics/*toxicity
EDAT- 2010/08/06 06:00
MHDA- 2011/02/01 06:00
CRDT- 2010/08/06 06:00
PHST- 2009/12/30 00:00 [received]
PHST- 2010/05/21 00:00 [revised]
PHST- 2010/05/24 00:00 [accepted]
PHST- 2010/08/06 06:00 [entrez]
PHST- 2010/08/06 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
AID - S1056-8719(10)00081-X [pii]
AID - 10.1016/j.vascn.2010.05.008 [doi]
PST - ppublish
SO  - J Pharmacol Toxicol Methods. 2010 Nov-Dec;62(3):236-42. doi:
      10.1016/j.vascn.2010.05.008. Epub 2010 May 31.


PMID- 20684885
OWN - NLM
STAT- MEDLINE
DCOM- 20110608
LR  - 20110110
IS  - 1096-0961 (Electronic)
IS  - 1079-9796 (Linking)
VI  - 46
IP  - 1
DP  - 2011 Jan 15
TI  - Preimplantation genetic diagnosis (PGD) for a treatable disorder: Gaucher disease
      type 1 as a model.
PG  - 15-8
LID - 10.1016/j.bcmd.2010.04.008 [doi]
AB  - BACKGROUND: Preimplantation genetic diagnosis (PGD) is a technique that enables
      identification of unaffected embryos prior to in vitro fertilization (IVF)
      transfer in couples at risk for a Mendelian disorder. Most cases involve severe
      genetic diseases with neurological features and/or major malformations. We
      present two couples in which PGD was performed for prevention of type 1 Gaucher
      disease, a non-neuronopathic, non-lethal disorder. MATERIALS AND METHODS: We
      developed a multiplex fluorescent PCR protocol, simultaneously amplifying the
      familial mutations and eight closely spaced, highly polymorphic informative
      microsatellite markers surrounding the gene, to be used for PGD analysis.
      RESULTS: Couple #1 mother was homozygous for the N370S mutation and the father
      carried the 84GG mutation; their first daughter receives specific Gaucher
      therapy. One PGD cycle resulted in seven embryos of which four had the paternal
      wild type allele; two were transferred resulting in a healthy baby boy born at
      term. Couple #2, each a carrier (N370S and R359Q), whose first-born child had
      died (age 5years) of Gaucher disease, underwent 7 PGD cycles. Only one cycle
      resulted in a clinical pregnancy but a miscarriage was followed at 10weeks.
      CONCLUSIONS: PGD is an effective and accurate method for preventing Gaucher
      disease type I in carrier couples. Since this disease is treatable, special
      ethical considerations and careful selection of couples should be performed.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Altarescu, Gheona
AU  - Altarescu G
AD  - Medical Genetics Institute, Shaare Zedek Medical Center, Jerusalem, Israel.
      gheona@szmc.org.il
FAU - Renbaum, Paul
AU  - Renbaum P
FAU - Eldar-Geva, Talia
AU  - Eldar-Geva T
FAU - Varshower, Irit
AU  - Varshower I
FAU - Brooks, Baruch
AU  - Brooks B
FAU - Beeri, Rachel
AU  - Beeri R
FAU - Margalioth, Ehud J
AU  - Margalioth EJ
FAU - Levy-Lahad, Ephrat
AU  - Levy-Lahad E
FAU - Elstein, Deborah
AU  - Elstein D
FAU - Zimran, Ari
AU  - Zimran A
LA  - eng
PT  - Journal Article
DEP - 20100601
PL  - United States
TA  - Blood Cells Mol Dis
JT  - Blood cells, molecules & diseases
JID - 9509932
SB  - IM
MH  - Female
MH  - Fertilization in Vitro/*methods
MH  - Gaucher Disease/*diagnosis/*genetics
MH  - Humans
MH  - Male
MH  - Pregnancy
MH  - *Preimplantation Diagnosis
EDAT- 2010/08/06 06:00
MHDA- 2011/06/09 06:00
CRDT- 2010/08/06 06:00
PHST- 2010/04/24 00:00 [received]
PHST- 2010/08/06 06:00 [entrez]
PHST- 2010/08/06 06:00 [pubmed]
PHST- 2011/06/09 06:00 [medline]
AID - S1079-9796(10)00122-1 [pii]
AID - 10.1016/j.bcmd.2010.04.008 [doi]
PST - ppublish
SO  - Blood Cells Mol Dis. 2011 Jan 15;46(1):15-8. doi: 10.1016/j.bcmd.2010.04.008.
      Epub 2010 Jun 1.


PMID- 20684850
OWN - NLM
STAT- MEDLINE
DCOM- 20101122
LR  - 20100816
IS  - 1873-2534 (Electronic)
IS  - 0165-2427 (Linking)
VI  - 137
IP  - 1-2
DP  - 2010 Sep 15
TI  - BCG vaccination failed to protect yearling African buffaloes (Syncerus caffer)
      against experimental intratonsilar challenge with Mycobacterium bovis.
PG  - 84-92
LID - 10.1016/j.vetimm.2010.04.013 [doi]
AB  - Vaccination has been discussed as a practical option to control bovine
      tuberculosis in countries where a wildlife reservoir of the disease is present.
      African buffaloes (Syncerus caffer) are the main wildlife reservoir of
      Mycobacterium bovis in certain South African game parks and vaccination is not
      only the most promising but the only ethically acceptable control measure
      currently available. The use of Bacillus Calmette-Guerin vaccine (Pasteur strain)
      to vaccinate fourteen African buffalo yearlings and their reactions to subsequent
      intratonsilar challenge with a field strain of M. bovis are described. The BCG
      vaccine was administered twice intramuscularly, six weeks apart. All vaccinates
      and thirteen control buffaloes were euthanized and necropsies performed 9 months 
      after the challenge. Standard sets of lymph nodes from the head, the thoracic
      cavity and abdomen were cultured and examined histopathologically. No significant
      reduction in number of lesions or severity of disease was noted, concluding that 
      the BCG vaccine did not induce sufficient protection able to limit the shedding
      of organisms. The age of the buffaloes, route of vaccination and prior exposure
      to environmental mycobacteria are among the possible reasons for vaccination
      failure.
CI  - Copyright 2010 Elsevier B.V. All rights reserved.
FAU - de Klerk, Lin-Mari
AU  - de Klerk LM
AD  - Veterinary Wildlife Services, Kruger National Park, P.O. Box 156, Skukuza 1350,
      South Africa. LinmarieDK@daff.gov.za
FAU - Michel, Anita L
AU  - Michel AL
FAU - Bengis, Roy G
AU  - Bengis RG
FAU - Kriek, Nicolaas P J
AU  - Kriek NP
FAU - Godfroid, Jacques
AU  - Godfroid J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100428
PL  - Netherlands
TA  - Vet Immunol Immunopathol
JT  - Veterinary immunology and immunopathology
JID - 8002006
RN  - 0 (BCG Vaccine)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - BCG Vaccine/*immunology
MH  - Buffaloes/*immunology
MH  - Cattle
MH  - Female
MH  - Interferon-gamma/biosynthesis
MH  - Male
MH  - Tuberculosis, Bovine/immunology/*prevention & control
MH  - *Vaccination
EDAT- 2010/08/06 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/06 06:00
PHST- 2009/11/26 00:00 [received]
PHST- 2010/04/13 00:00 [revised]
PHST- 2010/04/19 00:00 [accepted]
PHST- 2010/08/06 06:00 [entrez]
PHST- 2010/08/06 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S0165-2427(10)00128-5 [pii]
AID - 10.1016/j.vetimm.2010.04.013 [doi]
PST - ppublish
SO  - Vet Immunol Immunopathol. 2010 Sep 15;137(1-2):84-92. doi:
      10.1016/j.vetimm.2010.04.013. Epub 2010 Apr 28.


PMID- 20684183
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20151119
IS  - 1565-1088 (Print)
VI  - 12
IP  - 3
DP  - 2010 Mar
TI  - Ethical dilemmas for physicians in time of war.
PG  - 172-3
FAU - Malke, Borow
AU  - Malke B
LA  - eng
PT  - Comment
PT  - Editorial
PL  - Israel
TA  - Isr Med Assoc J
JT  - The Israel Medical Association journal : IMAJ
JID - 100930740
SB  - IM
CON - Isr Med Assoc J. 2010 Mar;12(3):133-5. PMID: 20684174
MH  - Beneficence
MH  - *Ethics, Medical
MH  - Human Rights
MH  - Humans
MH  - Military Medicine/ethics
MH  - Personal Autonomy
MH  - *Physicians/ethics
MH  - Torture/ethics
MH  - Warfare/*ethics
EDAT- 2010/08/06 06:00
MHDA- 2010/09/16 06:00
CRDT- 2010/08/06 06:00
PHST- 2010/08/06 06:00 [entrez]
PHST- 2010/08/06 06:00 [pubmed]
PHST- 2010/09/16 06:00 [medline]
PST - ppublish
SO  - Isr Med Assoc J. 2010 Mar;12(3):172-3.


PMID- 20684174
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20151119
IS  - 1565-1088 (Print)
VI  - 12
IP  - 3
DP  - 2010 Mar
TI  - Ethical dilemmas for physicians in time of war.
PG  - 133-5
AB  - During times of war, physicians are sometimes faced with the conflict of their
      professional duties to ensure the ethical principles of beneficence,
      non-maleficence, patient autonomy, and self-determination, within the framework
      of the proper ethical conduct in the practice of medicine, and the obligation and
      duties placed upon the physician by the state in times of war. Many ethical
      dilemmas may occur for the physician on the battlefield or elsewhere in the war
      region, including the treatment of detainees and the priority of treating wounded
      enemy soldiers or civilians first. When physicians are faced with a conflict
      between following state or national policies and following international
      principles of humanitarian law and medical ethics, the physician should opt for
      the latter. Physicians should not participate in any way in human rights abuses
      of detainees or prisoners when deployed in a war zone. Physicians must maintain
      the principles and standards and ethical considerations of their noble profession
      at all times.
FAU - Rosner, Fred
AU  - Rosner F
AD  - Elmhurst Hospital Center, Elmhurst, NY, USA. fsrosner@verizon.net
LA  - eng
PT  - Journal Article
PL  - Israel
TA  - Isr Med Assoc J
JT  - The Israel Medical Association journal : IMAJ
JID - 100930740
SB  - IM
CIN - Isr Med Assoc J. 2010 Mar;12(3):172-3. PMID: 20684183
MH  - Altruism
MH  - Beneficence
MH  - *Ethics, Medical
MH  - Human Rights
MH  - Human Rights Abuses/prevention & control
MH  - Humans
MH  - Military Medicine/ethics
MH  - Personal Autonomy
MH  - Physicians/*ethics
MH  - Prisoners
MH  - Terrorism/ethics
MH  - Torture/ethics
MH  - Warfare/*ethics
EDAT- 2010/08/06 06:00
MHDA- 2010/09/16 06:00
CRDT- 2010/08/06 06:00
PHST- 2010/08/06 06:00 [entrez]
PHST- 2010/08/06 06:00 [pubmed]
PHST- 2010/09/16 06:00 [medline]
PST - ppublish
SO  - Isr Med Assoc J. 2010 Mar;12(3):133-5.


PMID- 20683926
OWN - NLM
STAT- MEDLINE
DCOM- 20101216
LR  - 20211020
IS  - 1098-1004 (Electronic)
IS  - 1059-7794 (Linking)
VI  - 31
IP  - 11
DP  - 2010 Nov
TI  - Practical guidelines addressing ethical issues pertaining to the curation of
      human locus-specific variation databases (LSDBs).
PG  - 1179-84
LID - 10.1002/humu.21339 [doi]
AB  - More than 1,000 Web-based locus-specific variation databases (LSDBs) are listed
      on the Website of the Human Genetic Variation Society (HGVS). These individual
      efforts, which often relate phenotype to genotype, are a valuable source of
      information for clinicians, patients, and their families, as well as for basic
      research. The initiators of the Human Variome Project recently recognized that
      having access to some of the immense resources of unpublished information already
      present in diagnostic laboratories would provide critical data to help manage
      genetic disorders. However, there are significant ethical issues involved in
      sharing these data worldwide. An international working group presents
      second-generation guidelines addressing ethical issues relating to the curation
      of human LSDBs that provide information via a Web-based interface. It is intended
      that these should help current and future curators and may also inform the future
      decisions of ethics committees and legislators. These guidelines have been
      reviewed by the Ethics Committee of the Human Genome Organization (HUGO).
CI  - (c) 2010 Wiley-Liss, Inc.
FAU - Povey, Sue
AU  - Povey S
AD  - Department of Genetics, Evolution and Environment, University College London,
      London, United Kingdom. s.povey@ucl.ac.uk
FAU - Al Aqeel, Aida I
AU  - Al Aqeel AI
FAU - Cambon-Thomsen, Anne
AU  - Cambon-Thomsen A
FAU - Dalgleish, Raymond
AU  - Dalgleish R
FAU - den Dunnen, Johan T
AU  - den Dunnen JT
FAU - Firth, Helen V
AU  - Firth HV
FAU - Greenblatt, Marc S
AU  - Greenblatt MS
FAU - Barash, Carol Isaacson
AU  - Barash CI
FAU - Parker, Michael
AU  - Parker M
FAU - Patrinos, George P
AU  - Patrinos GP
FAU - Savige, Judith
AU  - Savige J
FAU - Sobrido, Maria-Jesus
AU  - Sobrido MJ
FAU - Winship, Ingrid
AU  - Winship I
FAU - Cotton, Richard G H
AU  - Cotton RG
CN  - Ethics Committee of the Human Genome Organization (HUGO)
LA  - eng
PT  - Guideline
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Mutat
JT  - Human mutation
JID - 9215429
SB  - IM
MH  - Confidentiality/ethics
MH  - Databases, Genetic/*ethics
MH  - *Genetic Variation
MH  - Humans
PMC - PMC2992689
EDAT- 2010/08/05 06:00
MHDA- 2010/12/17 06:00
CRDT- 2010/08/05 06:00
PHST- 2010/08/05 06:00 [entrez]
PHST- 2010/08/05 06:00 [pubmed]
PHST- 2010/12/17 06:00 [medline]
AID - 10.1002/humu.21339 [doi]
PST - ppublish
SO  - Hum Mutat. 2010 Nov;31(11):1179-84. doi: 10.1002/humu.21339.


PMID- 20683798
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20181127
IS  - 1526-4564 (Electronic)
IS  - 1526-4564 (Linking)
VI  - 28
IP  - 4
DP  - 2010 Jul
TI  - The use of eggs and embryos in stem cell research.
PG  - 336-44
LID - 10.1055/s-0030-1255182 [doi]
AB  - Stem cell research has enormous potential to advance knowledge about many
      diseases but poses critical ethical issues. Many countries and U.S. states have
      developed policies concerning this area that over time will surely evolve, yet
      certain underlying ethical principles and tensions will no doubt continue to
      remain key. Overall, the basic ethical principles of autonomy, beneficence,
      nonmalfeasance, and justice are crucial but have been viewed, interpreted, and
      applied differently by policy makers and others. Controversies remain concerning 
      what degree of respect eggs and embryos should receive; whether egg donors should
      be compensated, and if so, how much; what exactly to include in informed consent;
      and how to ensure appropriate oversight by institutional review boards and
      embryonic stem cell research oversight committees. This article addresses these
      areas and ways of approaching them, to adhere to important ethical principles,
      while helping to advance research that has the potential to help innumerable
      patients.
CI  - Thieme Medical Publishers.
FAU - Klitzman, Robert
AU  - Klitzman R
AD  - Division of Psychiatry, Law and Ethics; Ethics and Policy Core, Columbia
      University, New York State Psychiatric Institute, New York, New York, USA.
      Rlk2@columbia.edu
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100803
PL  - United States
TA  - Semin Reprod Med
JT  - Seminars in reproductive medicine
JID - 100909394
SB  - IM
MH  - Embryo Research/*ethics/history
MH  - Embryo, Mammalian/cytology/*physiology
MH  - Embryonic Stem Cells/*cytology/physiology
MH  - Ethics, Research
MH  - Female
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Ovum/cytology/*physiology
EDAT- 2010/08/05 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/05 06:00
PHST- 2010/08/05 06:00 [entrez]
PHST- 2010/08/05 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1055/s-0030-1255182 [doi]
PST - ppublish
SO  - Semin Reprod Med. 2010 Jul;28(4):336-44. doi: 10.1055/s-0030-1255182. Epub 2010
      Aug 3.


PMID- 20683797
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20181201
IS  - 1526-4564 (Electronic)
IS  - 1526-4564 (Linking)
VI  - 28
IP  - 4
DP  - 2010 Jul
TI  - Posthumous assisted reproduction.
PG  - 329-35
LID - 10.1055/s-0030-1255181 [doi]
AB  - Cryopreservation of gametes and embryos allows for children to be conceived after
      the death of their genetic parents through the process of posthumous assisted
      reproduction (PAR). Although the techniques are routine, the moral and ethical
      details are controversial and remain unsettled. Furthermore, there are numerous
      medicolegal implications that complicate matters. The principal parties to be
      considered are the decedent, the child who will be born of PAR, the significant
      other requesting the procedure, other living children, and even society at large.
      Numerous case studies exist and expert opinions have been published recognizing
      PAR as a vexing ethical issue. Most experts agree that explicit written consent
      forms signed at the time of cryopreservation are the best method to minimize some
      of the controversy involved with PAR.
CI  - Thieme Medical Publishers.
FAU - Nakhuda, Gary S
AU  - Nakhuda GS
AD  - Division of Reproductive Endocrinology and Infertility, Center for Women's
      Reproductive Care, New York, New York 10019, USA. Gsn16@columbia.edu
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100803
PL  - United States
TA  - Semin Reprod Med
JT  - Seminars in reproductive medicine
JID - 100909394
SB  - IM
MH  - Cryopreservation/ethics/methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Oocyte Retrieval/ethics/methods
MH  - Oocytes
MH  - Personal Autonomy
MH  - Posthumous Conception/*ethics
MH  - Practice Guidelines as Topic
MH  - Pregnancy
MH  - Reproductive Techniques, Assisted/*ethics/statistics & numerical data
MH  - Semen Preservation/ethics/methods/statistics & numerical data
EDAT- 2010/08/05 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/05 06:00
PHST- 2010/08/05 06:00 [entrez]
PHST- 2010/08/05 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1055/s-0030-1255181 [doi]
PST - ppublish
SO  - Semin Reprod Med. 2010 Jul;28(4):329-35. doi: 10.1055/s-0030-1255181. Epub 2010
      Aug 3.


PMID- 20683796
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20100804
IS  - 1526-4564 (Electronic)
IS  - 1526-4564 (Linking)
VI  - 28
IP  - 4
DP  - 2010 Jul
TI  - Ethics in egg donation: past, present, and future.
PG  - 322-8
LID - 10.1055/s-0030-1255180 [doi]
AB  - Since the advent of clinical human egg donation just over 25 years ago, ethical
      considerations have been central to its successful application and popular
      acceptance. Early in its history, "essentialist" arguments questioning the moral 
      validity of the practice altogether were commonplace. More recently, most
      academic discussion has been focused on "consequentialist" issues relating to
      practical approaches to egg donation that minimize ethically troublesome
      consequences. Three issues that have attracted a bulk of the attention in this
      regard are compensation, postmenopausal pregnancy, and egg sharing. Although much
      consensus has been reached on some very controversial issues, the enormous
      potential of increasingly successful oocyte cryopreservation, as well as emerging
      stem cell technologies, is very likely to provide abundant fuel for the continued
      debate of provocative and contentious ethical issues in human egg donation.
CI  - Thieme Medical Publishers.
FAU - Klein, Joshua U
AU  - Klein JU
AD  - Center for Women's Reproductive Care, Columbia University, New York, New York,
      USA.
FAU - Sauer, Mark V
AU  - Sauer MV
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100803
PL  - United States
TA  - Semin Reprod Med
JT  - Seminars in reproductive medicine
JID - 100909394
SB  - IM
MH  - Compensation and Redress
MH  - Female
MH  - Fertilization in Vitro/ethics
MH  - Humans
MH  - Male
MH  - Maternal Age
MH  - Oocyte Donation/economics/*ethics/methods/*trends
MH  - Postmenopause/physiology
MH  - Pregnancy
MH  - Religion and Medicine
EDAT- 2010/08/05 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/05 06:00
PHST- 2010/08/05 06:00 [entrez]
PHST- 2010/08/05 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1055/s-0030-1255180 [doi]
PST - ppublish
SO  - Semin Reprod Med. 2010 Jul;28(4):322-8. doi: 10.1055/s-0030-1255180. Epub 2010
      Aug 3.


PMID- 20683795
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20181201
IS  - 1526-4564 (Electronic)
IS  - 1526-4564 (Linking)
VI  - 28
IP  - 4
DP  - 2010 Jul
TI  - The ethics of sex selection and family balancing.
PG  - 315-21
LID - 10.1055/s-0030-1255179 [doi]
AB  - Ethical concerns about the ethics of selecting the sex of a child predate current
      techniques of prenatal genetic diagnosis (PGD) and sperm sorting. The only
      methods previously available were highly problematic, as they involved
      infanticide or abortion of an unwanted sex. PGD is less problematic than the
      earlier methods, yet still troubling to some because it involves destruction of a
      healthy embryo and risks to women. The technique of sperm sorting, still in an
      experimental phase, is the least ethically problematic method, yet opponents
      argue that sex selection by any means involves sex discrimination and can have
      undesirable consequences. One such consequence is an imbalance in the sex ratio. 
      This imbalance already exists in some Asian countries that favor male children,
      but is less likely in Western Europe and North America. There is increasing
      acceptance of family balancing as a reason for sex selection, but some people
      remain opposed to broadening the indications for sex selection of offspring
      beyond family balancing. Nevertheless, parents may have good reasons other than
      family balancing for choosing the sex of a future child. Such reasons may be
      justified by the principle of reproductive liberty.
CI  - Thieme Medical Publishers.
FAU - Macklin, Ruth
AU  - Macklin R
AD  - Albert Einstein College of Medicine, Bronx, New York, New York 10463, USA.
      ruth.macklin@einstein.yu.edu
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100803
PL  - United States
TA  - Semin Reprod Med
JT  - Seminars in reproductive medicine
JID - 100909394
SB  - IM
MH  - Choice Behavior/ethics
MH  - *Family Characteristics
MH  - Female
MH  - Humans
MH  - Male
MH  - Prejudice
MH  - Religion and Medicine
MH  - Sex Preselection/*ethics/methods/statistics & numerical data
MH  - Sex Ratio
MH  - Time Factors
EDAT- 2010/08/05 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/05 06:00
PHST- 2010/08/05 06:00 [entrez]
PHST- 2010/08/05 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1055/s-0030-1255179 [doi]
PST - ppublish
SO  - Semin Reprod Med. 2010 Jul;28(4):315-21. doi: 10.1055/s-0030-1255179. Epub 2010
      Aug 3.


PMID- 20683794
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20191210
IS  - 1526-4564 (Electronic)
IS  - 1526-4564 (Linking)
VI  - 28
IP  - 4
DP  - 2010 Jul
TI  - The ethical challenges of providing fertility care to patients with chronic
      illness or terminal disease.
PG  - 303-14
LID - 10.1055/s-0030-1255178 [doi]
AB  - The field of fertility is rapidly evolving, bringing opportunities for
      improvement in our patients' quality of life as well as bringing new ethical
      dilemmas. As medical science continues to advance, significant numbers of the
      reproductive-aged population are living with chronic and/or terminal conditions
      but have reasonable odds of lengthy survival and wish to have children. Likewise,
      there are adolescents diagnosed with cancer who are increasingly expected to
      achieve an improved, if not normal, life expectancy after treatment. Oftentimes
      these children are told they must sacrifice their ability to later have
      genetically related offspring; however, technologies to preserve fertility are
      changing this prognosis. Patients with chronic infection are living longer, more 
      normal lives and are increasingly seeking reproductive assistance. Moreover,
      there is an increasing number of patients' families desiring posthumous use of
      gametes, which also raises ethical and legal issues. This article discusses
      ethical principles of bioethics and then highlights specific ethical issues
      through four plausible cases that may be seen in a fertility practice providing
      medical care to patients with chronic illness or terminal disease. It concludes
      that prompt referral of patients to the reproductive endocrinologist, along with 
      a multidisciplinary approach to care, provides increased chances of successful
      treatment of this group of patients.
CI  - Thieme Medical Publishers.
FAU - Chilvers, Rebecca A
AU  - Chilvers RA
AD  - Department of Obstetrics and Gynecology, The University of Texas Medical Branch
      at Galveston, Galveston, Texas 77555-0587, USA. rachilve@utmb.edu
FAU - Hossain, Amjad
AU  - Hossain A
FAU - Phelps, John Y
AU  - Phelps JY
LA  - eng
PT  - Case Reports
PT  - Evaluation Study
PT  - Journal Article
PT  - Review
DEP - 20100803
PL  - United States
TA  - Semin Reprod Med
JT  - Seminars in reproductive medicine
JID - 100909394
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Chronic Disease/*therapy
MH  - Female
MH  - Humans
MH  - Infertility/etiology/*prevention & control/*therapy
MH  - Male
MH  - Pregnancy
MH  - Reproductive Techniques, Assisted/*ethics/statistics & numerical data
MH  - Risk Factors
MH  - Terminal Care/ethics/methods
MH  - *Terminally Ill
EDAT- 2010/08/05 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/05 06:00
PHST- 2010/08/05 06:00 [entrez]
PHST- 2010/08/05 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1055/s-0030-1255178 [doi]
PST - ppublish
SO  - Semin Reprod Med. 2010 Jul;28(4):303-14. doi: 10.1055/s-0030-1255178. Epub 2010
      Aug 3.


PMID- 20683793
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20220318
IS  - 1526-4564 (Electronic)
IS  - 1526-4564 (Linking)
VI  - 28
IP  - 4
DP  - 2010 Jul
TI  - Multifetal pregnancy reduction: evolution of the ethical arguments.
PG  - 295-302
LID - 10.1055/s-0030-1255177 [doi]
AB  - Multifetal pregnancy reduction (MFPR) was developed over 20 years ago to rescue
      higher-order multifetal pregnancies and has become a major component of improving
      the outcomes in infertility therapies. By definition, MFPR will always be
      controversial, but opinions do not follow the traditional "pro-life/pro-choice"
      dichotomy that has sabotaged the more generalized abortion debate. If one defines
      SUCCESS as a healthy mother and healthy offspring, clearly, with multiples, fewer
      are always safer. The ethical issues surrounding MFPR are for most people not a
      clear black-or-white but varying shades of gray. The ethical principle of
      proportionality takes precedence (i.e., trying to obtain the most good for the
      least harm while looking for areas of moral compromise to achieve the best
      outcomes).
CI  - Thieme Medical Publishers.
FAU - Evans, Mark I
AU  - Evans MI
AD  - Comprehensive Genetics, Fetal Medicine Foundation of America, New York, New York 
      10065, USA. Evans@Compregen.com
FAU - Britt, David W
AU  - Britt DW
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Review
DEP - 20100803
PL  - United States
TA  - Semin Reprod Med
JT  - Seminars in reproductive medicine
JID - 100909394
SB  - IM
MH  - *Cultural Evolution
MH  - Dissent and Disputes
MH  - Female
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Premature/physiology
MH  - Pregnancy
MH  - Pregnancy Reduction, Multifetal/*ethics/history/trends
MH  - United States
EDAT- 2010/08/05 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/05 06:00
PHST- 2010/08/05 06:00 [entrez]
PHST- 2010/08/05 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1055/s-0030-1255177 [doi]
PST - ppublish
SO  - Semin Reprod Med. 2010 Jul;28(4):295-302. doi: 10.1055/s-0030-1255177. Epub 2010 
      Aug 3.


PMID- 20683792
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20151119
IS  - 1526-4564 (Electronic)
IS  - 1526-4564 (Linking)
VI  - 28
IP  - 4
DP  - 2010 Jul
TI  - Ethical obligation for restricting the number of embryos transferred to women:
      combating the multiple-birth epidemic from in vitro fertilization.
PG  - 287-94
LID - 10.1055/s-0030-1255176 [doi]
AB  - In vitro fertilization (IVF) is an increasingly effective and popular means of
      achieving pregnancy for infertile women, but contributes to a growing incidence
      of risky twin pregnancies. Despite studies demonstrating cost-effective means to 
      achieve IVF pregnancy while strictly limiting the number of embryos transferred, 
      multiple-embryo transfer remains the most common practice in the United States,
      and twin pregnancies continue to increase. IVF providers resist restricting these
      practices, arguing that this is counter to principles of procreative liberty,
      patient and professional autonomy, and free-market economics. We counter that
      physicians have a professional fiduciary responsibility to weigh issues of
      nonmaleficence to patients and just use of health care resources with patient
      desires. With oversight from professional organizations, providers should follow 
      strict but medically appropriate restrictions on embryo transfer practices and
      work toward safer means of optimizing IVF outcomes than multiple-embryo transfer.
CI  - Thieme Medical Publishers.
FAU - Van Voorhis, Bradley J
AU  - Van Voorhis BJ
AD  - Department of Ob-Gyn, University of Iowa Carver College of Medicine, Iowa City,
      Iowa, USA.
FAU - Ryan, Ginny L
AU  - Ryan GL
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100803
PL  - United States
TA  - Semin Reprod Med
JT  - Seminars in reproductive medicine
JID - 100909394
SB  - IM
MH  - Embryo Transfer/*ethics/*methods/statistics & numerical data
MH  - Epidemics/prevention & control
MH  - Female
MH  - Fertilization in Vitro/*ethics/legislation & jurisprudence/methods/statistics &
      numerical data
MH  - Humans
MH  - Moral Obligations
MH  - Personal Autonomy
MH  - Practice Patterns, Physicians'/ethics/legislation & jurisprudence
MH  - Pregnancy
MH  - Pregnancy, Multiple/*statistics & numerical data
EDAT- 2010/08/05 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/05 06:00
PHST- 2010/08/05 06:00 [entrez]
PHST- 2010/08/05 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1055/s-0030-1255176 [doi]
PST - ppublish
SO  - Semin Reprod Med. 2010 Jul;28(4):287-94. doi: 10.1055/s-0030-1255176. Epub 2010
      Aug 3.


PMID- 20683791
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20181201
IS  - 1526-4564 (Electronic)
IS  - 1526-4564 (Linking)
VI  - 28
IP  - 4
DP  - 2010 Jul
TI  - Are you ever too old to have a baby? The ethical challenges of older women using 
      infertility services.
PG  - 281-6
LID - 10.1055/s-0030-1255175 [doi]
AB  - Older parenthood raises a variety of important factual and ethical questions.
      None of the questions have received sufficient attention despite the rapid
      expansion in the United States and other nations in the numbers of older parents.
      We do not know much about the safety, economic, and psychosocial impact of these 
      emerging practices on children or parents. Nor have there been many analytical
      considerations of the ethical issues raised. We argue in this article that there 
      are reasons for concern when older persons seek to utilize fertility treatments, 
      including the safety of pregnancy for older women, risks posed to children
      delivered by older mothers, issues around what constitutes safe conditions for
      having a child relative to the age of parents, and the importance of guaranteeing
      that someone will serve in the parental role should an older parent or parents
      become disabled or die. To protect the best interest of children created by
      technology in new familial circumstances, internationally recognized and enforced
      standards for fertility clinics to follow ought to be enacted in making decisions
      about treating older parents seeking infertility services.
CI  - Thieme Medical Publishers.
FAU - Caplan, Art L
AU  - Caplan AL
AD  - Center for Bioethics, University of Pennsylvania, Philadelphia, Pennsylvania,
      USA.
FAU - Patrizio, Pasquale
AU  - Patrizio P
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100803
PL  - United States
TA  - Semin Reprod Med
JT  - Seminars in reproductive medicine
JID - 100909394
SB  - IM
MH  - Age Factors
MH  - Aging/physiology
MH  - Female
MH  - Health Services/ethics/statistics & numerical data
MH  - Health Services Accessibility/ethics/legislation & jurisprudence/trends
MH  - Humans
MH  - Infertility, Female/*therapy
MH  - International Cooperation
MH  - Male
MH  - *Maternal Age
MH  - Parenting/trends
MH  - Pregnancy
MH  - Reproductive Techniques, Assisted/*ethics/legislation & jurisprudence/statistics 
      & numerical data
EDAT- 2010/08/05 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/05 06:00
PHST- 2010/08/05 06:00 [entrez]
PHST- 2010/08/05 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1055/s-0030-1255175 [doi]
PST - ppublish
SO  - Semin Reprod Med. 2010 Jul;28(4):281-6. doi: 10.1055/s-0030-1255175. Epub 2010
      Aug 3.


PMID- 20683182
OWN - NLM
STAT- MEDLINE
DCOM- 20101122
LR  - 20191210
IS  - 1473-6578 (Electronic)
IS  - 0951-7367 (Linking)
VI  - 23
IP  - 5
DP  - 2010 Sep
TI  - Forensic psychiatry in some Balkan countries.
PG  - 472-80
LID - 10.1097/YCO.0b013e32833cfc05 [doi]
AB  - PURPOSE OF REVIEW: In Balkan countries, as in all Europe, forensic psychiatry as 
      a subspecialty between psychiatry and legal medicine, an interface between mental
      health and the law, is focused on assessment and treatment of people with mental 
      disorder who show antisocial or violent behavior. Thus, the authors thought that 
      to show the actual situation of forensic psychiatry in their countries would be
      more interesting than only to review some articles published in these last 2
      years in this part of the world. RECENT FINDINGS: The article also includes some 
      review about forensic psychiatry in prison in Bulgaria, Serbia and Russia and
      about a recent book published in Bulgaria. SUMMARY: After a brief history of
      forensic psychiatry in some Balkan countries, the authors describe the services, 
      the high and medium secure units found in forensic hospitals or in general
      psychiatry hospitals, which are still limited, where mentally disordered
      offenders are treated. Because of our society's values, individual freedom and
      civil liberties, questions about the right to treatment (or the right to refuse
      treatment), involuntary hospitalization, and other legal and ethical issues have 
      no easy answers. Ethical questions remain in dispute, like patient's needs vs.
      social needs and human rights, legality vs. morality.The quality standards must
      be improved, especially those concerning elementary care needs and quality of
      life of forensic psychiatry patients (accommodation, food, sheltered housing,
      sheltered work places and community involvement). Ways will be found to protect
      human rights and avoid any abuse of psychiatry.
FAU - Tataru, Nicoleta
AU  - Tataru N
AD  - Forensic Psychiatry Hospital Stei, Romania. nicol_tataru@yahoo.ca
FAU - Marinov, Petar
AU  - Marinov P
FAU - Douzenis, Athanassios
AU  - Douzenis A
FAU - Novotni, Antoni
AU  - Novotni A
FAU - Kecman, Bojana
AU  - Kecman B
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Psychiatry
JT  - Current opinion in psychiatry
JID - 8809880
SB  - IM
MH  - Bulgaria
MH  - *Forensic Psychiatry/legislation & jurisprudence/organization & administration
MH  - Greece
MH  - Humans
MH  - Mental Competency
MH  - Mental Health
MH  - Mental Health Services/organization & administration
MH  - Prisons/legislation & jurisprudence
MH  - Republic of North Macedonia
MH  - Romania
MH  - Serbia
EDAT- 2010/08/05 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/05 06:00
PHST- 2010/08/05 06:00 [entrez]
PHST- 2010/08/05 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1097/YCO.0b013e32833cfc05 [doi]
AID - 00001504-201009000-00016 [pii]
PST - ppublish
SO  - Curr Opin Psychiatry. 2010 Sep;23(5):472-80. doi: 10.1097/YCO.0b013e32833cfc05.


PMID- 20683180
OWN - NLM
STAT- MEDLINE
DCOM- 20101122
LR  - 20100804
IS  - 1473-6578 (Electronic)
IS  - 0951-7367 (Linking)
VI  - 23
IP  - 5
DP  - 2010 Sep
TI  - Objectivity and ethics in forensic psychiatry.
PG  - 447-52
LID - 10.1097/YCO.0b013e32833cd1e6 [doi]
AB  - PURPOSE OF REVIEW: In this paper, we analyze the concept of objectivity as it is 
      accepted in the 'standard position' on ethical practice in forensic psychiatry
      and confront it with the current trends of psychiatric nosology, specially the
      debate that we have now regarding the theoretical orientation of DSM-5, which is 
      intended to be more based on neuroscientific more than on clinical data, as has
      been the tradition in psychiatry so far. RECENT FINDINGS: In view of those
      elements, we review the skeptical position about the ethics of forensic
      psychiatry and the obstacles that, in my opinion, are still standing according to
      Stone's proposal: the fact-value distinction, determinism vs. free will, the
      deconstruction of the self, the mind-brain problem, and the chasm between
      morality and normal science. In my opinion the objections made by Stone on the
      feasibility of forensic psychiatry in the courts continue in full force, to the
      extent that these objections are the heart of the debate about the theoretical
      orientation of the DSM-5. SUMMARY: The advocates of the standard position have an
      overly optimistic view of the capacity of objectification of forensic psychiatry.
      This problem has also been revealed in the intense debates on the direction of
      the DSM-5 in general psychiatry, a draft of which appears excessively based on
      neuroscience and little on traditional clinical practice.
FAU - Calcedo-Barba, Alfredo
AU  - Calcedo-Barba A
AD  - Department of Psychiatry, Hospital Gregorio Maranon, Ibiza, Madrid, Spain.
      calcedo@med.ucm.es
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Psychiatry
JT  - Current opinion in psychiatry
JID - 8809880
SB  - IM
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Forensic Psychiatry/*ethics/methods
MH  - Humans
MH  - Mental Disorders/diagnosis/therapy
MH  - Observer Variation
MH  - Social Values
EDAT- 2010/08/05 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/05 06:00
PHST- 2010/08/05 06:00 [entrez]
PHST- 2010/08/05 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1097/YCO.0b013e32833cd1e6 [doi]
AID - 00001504-201009000-00011 [pii]
PST - ppublish
SO  - Curr Opin Psychiatry. 2010 Sep;23(5):447-52. doi: 10.1097/YCO.0b013e32833cd1e6.


PMID- 20682858
OWN - NLM
STAT- MEDLINE
DCOM- 20100908
LR  - 20220318
IS  - 1476-1645 (Electronic)
IS  - 0002-9637 (Linking)
VI  - 83
IP  - 2
DP  - 2010 Aug
TI  - Short-term global health research projects by US medical students: ethical
      challenges for partnerships.
PG  - 211-4
LID - 10.4269/ajtmh.2010.09-0692 [doi]
AB  - Recent interest in global health among medical students has grown drastically,
      and many students now spend time abroad conducting short-term research projects
      in low-resource settings. These short-term stints in developing countries present
      important ethical challenges to US-based students and their medical schools as
      well as the institutions that host such students abroad. This paper outlines some
      of these ethical issues and puts forth recommendations for ethically mindful
      short-term student research.
FAU - Provenzano, Audrey M
AU  - Provenzano AM
AD  - Yale University School of Medicine, New Haven, CT, USA.
      audrey.provenzano@gmail.com
FAU - Graber, Lauren K
AU  - Graber LK
FAU - Elansary, Mei
AU  - Elansary M
FAU - Khoshnood, Kaveh
AU  - Khoshnood K
FAU - Rastegar, Asghar
AU  - Rastegar A
FAU - Barry, Michele
AU  - Barry M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Trop Med Hyg
JT  - The American journal of tropical medicine and hygiene
JID - 0370507
SB  - IM
CIN - Indian J Med Ethics. 2011 Jul-Sep;8(3):187-8. PMID: 22106652
MH  - Biomedical Research/economics/*ethics/standards
MH  - Developing Countries
MH  - Education, Medical, Undergraduate/*ethics
MH  - *Ethics, Medical
MH  - *Ethics, Research
MH  - *Global Health
MH  - Healthcare Disparities/*economics/ethics
MH  - Humans
MH  - Informed Consent/ethics
MH  - International Cooperation
MH  - Program Development
MH  - Schools, Medical
MH  - Students, Medical
MH  - Time Factors
MH  - United States
PMC - PMC2911161
EDAT- 2010/08/05 06:00
MHDA- 2010/09/09 06:00
CRDT- 2010/08/05 06:00
PHST- 2010/08/05 06:00 [entrez]
PHST- 2010/08/05 06:00 [pubmed]
PHST- 2010/09/09 06:00 [medline]
AID - 83/2/211 [pii]
AID - 10.4269/ajtmh.2010.09-0692 [doi]
PST - ppublish
SO  - Am J Trop Med Hyg. 2010 Aug;83(2):211-4. doi: 10.4269/ajtmh.2010.09-0692.


PMID- 20682756
OWN - NLM
STAT- MEDLINE
DCOM- 20110718
LR  - 20211020
IS  - 1554-6179 (Electronic)
IS  - 1539-4182 (Linking)
VI  - 9
IP  - 1
DP  - 2011 Mar
TI  - Metabolic syndrome: comparison of occurrence using three definitions in
      hypertensive patients.
PG  - 26-31
LID - 10.3121/cmr.2010.902 [doi]
AB  - OBJECTIVE: To compare the frequency of occurrence of metabolic syndrome using
      three international definitions and to study the distribution of cardiovascular
      risk factors among newly diagnosed hypertensive Nigerian subjects. DESIGN: Cross 
      sectional study. SETTINGS: Cardiology unit of LAUTECH Teaching Hospital, Osogbo, 
      Nigeria. PARTICIPANTS: One hundred forty newly diagnosed hypertensive Nigerian
      subjects, and 70 normotensive controls (age- and sex-matched) were included in
      this study. METHODS: Clinical history and relevant laboratory investigations were
      performed on all study participants. The definition of metabolic syndrome was
      based on three international definitions: World Health Organization (WHO),
      International Diabetes Federation (IDF), and National Cholesterol Education
      Program Adult Treatment Panel III (NCEP ATP III). Ethical approval was obtained
      for the study. Statistical analyses were performed using SPSS 16.0. RESULTS:
      There was no difference in age and gender distribution between the hypertensive
      subjects and controls. (55.14 +/- 10.83 years, females 53.6% vs. 54.67 +/- 10.89 
      years, females 52.9% respectively, P>0.05). The frequency of occurrence of
      metabolic syndrome among hypertensives was 34.5% according to WHO, 35.0%
      according to NCEP ATP III, and 42.5% according to IDF criteria. Visceral obesity 
      and reduced high-density lipoprotein (HDL) were the other common cardiovascular
      risk factors among newly diagnosed hypertensive subjects. Female hypertensives
      had a higher prevalence of visceral obesity and low HDL. CONCLUSION: Frequency of
      occurrence of metabolic syndrome was similar using the NCEP ATP III and WHO
      definitions. However, the IDF definition resulted in a higher frequency because
      of the lower cut-off for waist circumference used for identification of visceral 
      obesity. Metabolic syndrome is present in a significant proportion of newly
      diagnosed hypertensive subjects. Therefore, appropriate screening and treatment
      are required.
FAU - Akintunde, Adeseye A
AU  - Akintunde AA
AD  - Division of Cardiology, Ladoke Akintola University of Technology Teaching
      Hospital, Osogbo, Nigeria. iakintunde2@yahoo.com
FAU - Ayodele, Olugbenga E
AU  - Ayodele OE
FAU - Akinwusi, Patience O
AU  - Akinwusi PO
FAU - Opadijo, George O
AU  - Opadijo GO
LA  - eng
PT  - Journal Article
DEP - 20100803
PL  - United States
TA  - Clin Med Res
JT  - Clinical medicine & research
JID - 101175887
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Hypertension/classification/*diagnosis/*epidemiology
MH  - Male
MH  - Metabolic Syndrome/*diagnosis/*epidemiology
MH  - Middle Aged
MH  - Nigeria/epidemiology
PMC - PMC3064758
EDAT- 2010/08/05 06:00
MHDA- 2011/07/19 06:00
CRDT- 2010/08/05 06:00
PHST- 2010/08/05 06:00 [entrez]
PHST- 2010/08/05 06:00 [pubmed]
PHST- 2011/07/19 06:00 [medline]
AID - cmr.2010.902 [pii]
AID - 10.3121/cmr.2010.902 [doi]
PST - ppublish
SO  - Clin Med Res. 2011 Mar;9(1):26-31. doi: 10.3121/cmr.2010.902. Epub 2010 Aug 3.


PMID- 20682160
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20191210
IS  - 1806-907X (Electronic)
IS  - 0034-7094 (Linking)
VI  - 60
IP  - 3
DP  - 2010 May-Jun
TI  - Evaluation of a computerized anesthesia report.
PG  - 285-301
LID - 10.1016/S0034-7094(10)70036-2 [doi]
AB  - BACKGROUND AND OBJECTIVES: In Brazil, the use of information systems that allows 
      filling out anesthesia reports automatically is still in its initial stages. The 
      objective of this study was to validate an automated anesthesia record. METHODS: 
      This study was approved by the Ethics Commission of the institution; an
      industry-university partnership (Dixtal, Sao Paulo, Brazil and Universidade de
      Sao Paulo) was developed, and the study received a grant from FINEP (Financiadora
      de Estudos e Projetos do Ministerio de Ciencia e Tecnologia). The integration of 
      hospital information systems for recovery of data regarding identification,
      preoperative evaluation, and laboratorial exams was the premise of this study.
      The applicability of the final version of the prototype of the automated system
      was evaluated by applying a semi-structured tool to 33 physicians, residents,
      and/or anesthesiologists during surgery procedures in 66 patients. Descriptive
      evaluation of the data was undertaken. RESULTS: The computerized system was
      considered reliable even for large surgeries by 81% of the participants. The
      majority of the anesthesiologists considered the prototype of great value for
      future studies and capable of meeting the requirements of anesthesia reports,
      bringing benefits for anesthesiologists, patients, and hospitals. The full use of
      the system requires training and some of its aspects can be improved.
      CONCLUSIONS: Validation of this prototype of a computerized system for
      elaboration of anesthesia reports showed the viability of this type of solution
      to help anesthesiologists in their daily tasks, increasing the reliability of the
      data. Besides, when evaluating the applicability, anesthesiologists considered
      that the prototype could be useful for patients, physicians, and hospitals.
CI  - Copyright 2010 Elsevier Editora Ltda. All rights reserved.
FAU - Zamper, Raffael Pereira Cezar
AU  - Zamper RP
AD  - Anesthesiology Subject and Anesthesia Division of Instituto Central do Hospital
      das Clinicas (HC) of Faculdade de Medicina da Universidade de Sao Paulo (FMUSP), 
      SP.
FAU - Torres, Marcelo Luis Abramides
AU  - Torres ML
FAU - Ferraz, Janice Leao
AU  - Ferraz JL
FAU - Neto, Silvio Mori
AU  - Neto SM
FAU - Holzhacker, Rafael
AU  - Holzhacker R
FAU - Shimada, Vanessa
AU  - Shimada V
FAU - Carmona, Maria Jose Carvalho
AU  - Carmona MJ
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Validation Study
PL  - Brazil
TA  - Rev Bras Anestesiol
JT  - Revista brasileira de anestesiologia
JID - 0401316
SB  - IM
MH  - *Anesthesia
MH  - Humans
MH  - *Medical Records Systems, Computerized
EDAT- 2010/08/05 06:00
MHDA- 2011/01/07 06:00
CRDT- 2010/08/05 06:00
PHST- 2009/06/30 00:00 [received]
PHST- 2010/01/20 00:00 [accepted]
PHST- 2010/08/05 06:00 [entrez]
PHST- 2010/08/05 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
AID - S0034-7094(10)70036-2 [pii]
AID - 10.1016/S0034-7094(10)70036-2 [doi]
PST - ppublish
SO  - Rev Bras Anestesiol. 2010 May-Jun;60(3):285-301. doi:
      10.1016/S0034-7094(10)70036-2.


PMID- 20682157
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20140205
IS  - 1806-907X (Electronic)
IS  - 0034-7094 (Linking)
VI  - 60
IP  - 3
DP  - 2010 May-Jun
TI  - Assessing the impact of lung hyperinflation maneuver on systemic inflammatory
      response and lung collapse in patients undergoing surgeries under spontaneous
      ventilation.
PG  - 247-58
LID - 10.1016/S0034-7094(10)70033-7 [doi]
AB  - BACKGROUND AND OBJECTIVES: Lung hyperinflation maneuvers (LHM) reverse
      intraoperative atelectasis; however, they can lead to pulmonary-induced systemic 
      inflammatory response. The objective of this study was to determine the impact of
      LHM on systemic inflammatory response and lung structure in patients undergoing
      subarachnoid block. METHODS: After approval by the Ethics Committee of the
      institution and signing the informed consent, 20 patients undergoing small and
      medium surgical procedures were randomly separated into two groups: 1) control
      (CG), and 2) LHM (LHMG). One hour after the spinal anesthesia, LHM was performed 
      in LHMG by applying bilevel positive pressure in the airways (BIPAP) with an
      expiratory pressure of 20 cmH(2)O and inspiratory pressure of 20 cmH(2)O for 1 to
      2 minutes. Blood levels of TNFalpha, IL-1, IL-6, IL-8, IL-10, and IL-12 were
      determined by flow cytometry at baseline and at 90, 180, and 780 minutes. Lung
      volumes and weights were determined using CT scans obtained immediately after the
      surgery. RESULTS: The use of LHM resulted in a reduction in the fraction of
      non-aerated pulmonary parenchyma (7.5 +/- 4.3%, in the Control Group, vs. 4 +/-
      2.1%, in the LHM Group, p = 0.02) without changing pulmonary volumes. A
      progressive increase in plasma levels of IL-1, IL-6, IL-8, and IL-10, similar in 
      both groups, was observed. Plasma levels of TNFalpha and IL-12 were undetectable 
      during the study. CONCLUSIONS: The use of LHM reduced the incidence of
      atelectasis, but it did not amplify the inflammatory response in patients with
      normal lungs undergoing small and medium surgeries under subarachnoid block.
CI  - Copyright 2010 Elsevier Editora Ltda. All rights reserved.
FAU - Malbouisson, Luiz Marcelo Sa
AU  - Malbouisson LM
AD  - Hospital das Clinicas (HC) of the Faculdade de Medicina da Universidade de Sao
      Paulo (FMUSP), Sao Paulo, SP, Brasil. malbouisson@hcnet.usp.br
FAU - de Souza, Elton Lucio Silva
AU  - de Souza EL
FAU - Barbalho, Larissa
AU  - Barbalho L
FAU - Massoco, Cristina de Oliveira
AU  - Massoco Cde O
FAU - Carmona, Maria Jose Carvalho
AU  - Carmona MJ
FAU - Auler, Jose Otavio Costa Jr
AU  - Auler JO Jr
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Brazil
TA  - Rev Bras Anestesiol
JT  - Revista brasileira de anestesiologia
JID - 0401316
SB  - IM
MH  - *Anesthesia, Spinal
MH  - Female
MH  - Humans
MH  - Inflammation/blood/*etiology/pathology
MH  - Intraoperative Complications/*therapy
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Atelectasis/blood/pathology/*therapy
MH  - Respiratory Therapy/*adverse effects
MH  - Surgical Procedures, Operative
EDAT- 2010/08/05 06:00
MHDA- 2011/01/07 06:00
CRDT- 2010/08/05 06:00
PHST- 2009/05/13 00:00 [received]
PHST- 2010/01/20 00:00 [accepted]
PHST- 2010/08/05 06:00 [entrez]
PHST- 2010/08/05 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
AID - S0034-7094(10)70033-7 [pii]
AID - 10.1016/S0034-7094(10)70033-7 [doi]
PST - ppublish
SO  - Rev Bras Anestesiol. 2010 May-Jun;60(3):247-58. doi:
      10.1016/S0034-7094(10)70033-7.


PMID- 20682156
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20140205
IS  - 1806-907X (Electronic)
IS  - 0034-7094 (Linking)
VI  - 60
IP  - 3
DP  - 2010 May-Jun
TI  - Comparison of the effects of dobutamine and milrinone on hemodynamic parameters
      and oxygen supply in patients undergoing cardiac surgery with low cardiac output 
      after anesthetic induction.
PG  - 237-46
LID - 10.1016/S0034-7094(10)70032-5 [doi]
AB  - BACKGROUND AND OBJECTIVES: Several classes of inotropic drugs with different
      hemodynamic effects are used in the treatment of low cardiac output in patients
      with diastolic dysfunction undergoing cardiac surgery. The objective of the
      present study was to compare the effects of dobutamine and milrinone on
      hemodynamic parameters and oxygen supply in this population of patients. METHODS:
      After approval by the Ethics Committee of the institution and signing of the
      informed consent, 20 patients undergoing cardiac surgery with cardiac index < 2
      L*min(-1)*m(2) after anesthetic induction and placement of a pulmonary artery
      catheter were randomly divided to receive dobutamine 5 microg*kg(-1). min(-1) (n 
      = 10), or milrinone 0.5 microg*kg(-1)*min(-1) (n = 10). Hemodynamic parameters
      were measured after anesthetic induction and after 30 and 60 minutes, and
      arterial and venous blood gases were measured at baseline and 60 minutes.
      Non-paired Student t test or two-way ANOVA for repeated measurements was used to 
      compare the data. RESULTS: Dobutamine and milrinone promoted significant
      increases in cardiac index (56% and 47%) and oxygen supply (53% and 45%), and
      reduction in systemic (33% and 36%) and pulmonary (34% and 19%) vascular
      resistance, respectively. However, statistically significant differences were not
      observed between both drugs. CONCLUSIONS: Both inotropic drugs were similarly
      effective in restoring tissue blood flow and oxygen supply to adequate levels in 
      patients with low cardiac output undergoing cardiac surgery.
CI  - Copyright 2010 Elsevier Editora Ltda. All rights reserved.
FAU - Carmona, Maria Jose Carvalho
AU  - Carmona MJ
AD  - Discipline of Anesthesiology of the Faculdade de Medicina da Universidade de Sao 
      Paulo (FMUSP), SP. maria.carmona@incor.usp.br
FAU - Martins, Laura Mariana
AU  - Martins LM
FAU - Vane, Matheus Fachini
AU  - Vane MF
FAU - Longo, Breno Altero
AU  - Longo BA
FAU - Paredes, Lemuel Silva
AU  - Paredes LS
FAU - Malbouisson, Luiz Marcelo Sa
AU  - Malbouisson LM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Brazil
TA  - Rev Bras Anestesiol
JT  - Revista brasileira de anestesiologia
JID - 0401316
RN  - 0 (Cardiotonic Agents)
RN  - 3S12J47372 (Dobutamine)
RN  - JU9YAX04C7 (Milrinone)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Aged
MH  - *Anesthesia
MH  - Cardiac Output, Low/*drug therapy/*metabolism
MH  - Cardiac Surgical Procedures
MH  - Cardiotonic Agents/*pharmacology
MH  - Dobutamine/*pharmacology
MH  - Female
MH  - Hemodynamics/*drug effects
MH  - Humans
MH  - Intraoperative Complications/*drug therapy
MH  - Male
MH  - Middle Aged
MH  - Milrinone/*pharmacology
MH  - Oxygen/*metabolism
EDAT- 2010/08/05 06:00
MHDA- 2011/01/07 06:00
CRDT- 2010/08/05 06:00
PHST- 2009/04/02 00:00 [received]
PHST- 2010/01/20 00:00 [accepted]
PHST- 2010/08/05 06:00 [entrez]
PHST- 2010/08/05 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
AID - S0034-7094(10)70032-5 [pii]
AID - 10.1016/S0034-7094(10)70032-5 [doi]
PST - ppublish
SO  - Rev Bras Anestesiol. 2010 May-Jun;60(3):237-46. doi:
      10.1016/S0034-7094(10)70032-5.


PMID- 20682023
OWN - NLM
STAT- MEDLINE
DCOM- 20101021
LR  - 20211020
IS  - 1471-2393 (Electronic)
IS  - 1471-2393 (Linking)
VI  - 10
DP  - 2010 Aug 3
TI  - Prevention of gestational diabetes: design of a cluster-randomized controlled
      trial and one-year follow-up.
PG  - 39
LID - 10.1186/1471-2393-10-39 [doi]
AB  - BACKGROUND: Annual prevalence of gestational diabetes mellitus (GDM) is 12.5%
      among Finnish pregnant women. The prevalence is expected to rise with the
      increasing overweight among women before pregnancy. Physical activity and diet
      are both known to have favourable effects on insulin resistance and possibly on
      the risk of GDM. We aimed to investigate, whether GDM can be prevented by
      counseling on diet, physical activity and gestational weight gain during
      pregnancy. METHODS/DESIGN: A cluster-randomized controlled trial was conducted in
      14 municipalities in the southern part of Finland. Pairwise randomization was
      performed in order to take into account socioeconomic differences. Recruited
      women were at 8-12 weeks' gestation and fulfilled at least one of the following
      criteria: body mass index>or=25 kg/m2, history of earlier gestational glucose
      intolerance or macrosomic newborn (>4500 g), age>or=40 years, first or second
      degree relative with history of type 1 or 2 diabetes. Main exclusion criterion
      was pathological oral glucose tolerance test (OGTT) at 8-12 weeks' gestation. The
      trial included one counseling session on physical activity at 8-12 weeks'
      gestation and one for diet at 16-18 weeks' gestation, and three to four booster
      sessions during other routine visits. In the control clinics women received usual
      care. Information on height, weight gain and other gestational factors was
      obtained from maternity cards. Physical activity, dietary intake and quality of
      life were followed by questionnaires during pregnancy and at 1-year postpartum.
      Blood samples for lipid status, hormones, insulin and OGTT were taken at 8-12 and
      26-28 weeks' gestation and 1 year postpartum. Workability and return to work were
      elicited by a questionnaire at 1- year postpartum. Linkage to the national birth 
      register of years 2007-2009 will provide information on perinatal complications
      and GDM incidence among the non-participants of the study. Cost-effectiveness
      evaluation will be based on quality-adjusted life years. This study has received 
      ethical approval from the Ethical board of Pirkanmaa Hospital District.
      DISCUSSION: The study will provide information on the effectiveness and
      cost-effectiveness of gestational physical activity and dietary counseling on
      prevention of GDM in a risk group of women. Also information on the prevalence of
      GDM and postpartum metabolic syndrome will be gained. Results on maintaining the 
      possible health behaviour changes are important in order to prevent chronic
      diseases such as cardiovascular disease and diabetes. TRIAL REGISTRATION: The
      trial is registered ISRCTN 33885819.
FAU - Luoto, Riitta M
AU  - Luoto RM
AD  - The UKK Institute for Health Promotion Research, Tampere, Finland.
FAU - Kinnunen, Tarja I
AU  - Kinnunen TI
FAU - Aittasalo, Minna
AU  - Aittasalo M
FAU - Ojala, Katriina
AU  - Ojala K
FAU - Mansikkamaki, Kirsi
AU  - Mansikkamaki K
FAU - Toropainen, Erja
AU  - Toropainen E
FAU - Kolu, Paivi
AU  - Kolu P
FAU - Vasankari, Tommi
AU  - Vasankari T
LA  - eng
SI  - ISRCTN/ISRCTN33885819
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20100803
PL  - England
TA  - BMC Pregnancy Childbirth
JT  - BMC pregnancy and childbirth
JID - 100967799
SB  - IM
MH  - Cost-Benefit Analysis
MH  - Counseling/economics
MH  - Diabetes, Gestational/*prevention & control
MH  - Exercise
MH  - Feeding Behavior
MH  - Female
MH  - Finland
MH  - Follow-Up Studies
MH  - Humans
MH  - Pregnancy
MH  - *Prenatal Care/economics
MH  - *Research Design
PMC - PMC2923097
EDAT- 2010/08/05 06:00
MHDA- 2010/10/22 06:00
CRDT- 2010/08/05 06:00
PHST- 2010/01/29 00:00 [received]
PHST- 2010/08/03 00:00 [accepted]
PHST- 2010/08/05 06:00 [entrez]
PHST- 2010/08/05 06:00 [pubmed]
PHST- 2010/10/22 06:00 [medline]
AID - 1471-2393-10-39 [pii]
AID - 10.1186/1471-2393-10-39 [doi]
PST - epublish
SO  - BMC Pregnancy Childbirth. 2010 Aug 3;10:39. doi: 10.1186/1471-2393-10-39.


PMID- 20681260
OWN - NLM
STAT- MEDLINE
DCOM- 20100902
LR  - 20211203
IS  - 0009-918X (Print)
IS  - 0009-918X (Linking)
VI  - 50
IP  - 7
DP  - 2010 Jul
TI  - [Advances in induced pluripotent stem cell research for neurological diseases].
PG  - 449-54
AB  - In 2006, Takahashi and Yamanaka reported a groundbreaking study showing mouse and
      human somatic cells that can be reprogrammed to the pluripotent state by
      expression of only a few transcription factors (Oct4, Sox2, Klf4, and c-Myc).
      This novel strategy can be used for transplantation therapies without immune
      rejection providing additional advantages regarding ethic issues of oocyte
      donation. For neurological diseases, disease-specific induced pluripotent stem
      (iPS) cells may serve as an invaluable model for clarifying pathogenesis and for 
      screening new drug therapies. In particular, differentiated neurons derived from 
      patient iPS cells could infinitely provide an alternative cellular-biochemical
      material for research instead of biopsy and autopsy. This review summarizes the
      current studies applying iPS cells in the field of neurology and discusses their 
      potential and limitations for therapy against neurological diseases.
FAU - Ito, Daisuke
AU  - Ito D
AD  - Department of Neurology, School of Medicine, Keio University.
FAU - Yagi, Takuya
AU  - Yagi T
FAU - Nihei, Yoshihiro
AU  - Nihei Y
FAU - Yoshizaki, Takahito
AU  - Yoshizaki T
FAU - Suzuki, Norihiro
AU  - Suzuki N
LA  - jpn
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Rinsho Shinkeigaku
JT  - Rinsho shinkeigaku = Clinical neurology
JID - 0417466
SB  - IM
MH  - Animals
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - Kruppel-Like Factor 4
MH  - Mice
MH  - Nervous System Diseases/therapy
MH  - Pluripotent Stem Cells
RF  - 30
EDAT- 2010/08/05 06:00
MHDA- 2010/09/03 06:00
CRDT- 2010/08/05 06:00
PHST- 2010/08/05 06:00 [entrez]
PHST- 2010/08/05 06:00 [pubmed]
PHST- 2010/09/03 06:00 [medline]
AID - 10.5692/clinicalneurol.50.449 [doi]
PST - ppublish
SO  - Rinsho Shinkeigaku. 2010 Jul;50(7):449-54. doi: 10.5692/clinicalneurol.50.449.


PMID- 20640332
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20190907
IS  - 1678-4561 (Electronic)
IS  - 1413-8123 (Linking)
VI  - 15 Suppl 1
DP  - 2010 Jun
TI  - [Manipulation of the human genome: ethics and law].
PG  - 1709-13
LID - S1413-81232010000700082 [pii]
AB  - The molecular biology has provided the basic tool for geneticists deepening in
      the molecular mechanisms that influence different diseases. It should be noted
      the scientific and moral responsibility of the researchers, because the
      scientists should imagine the moral consequences of the commercial application of
      genetic tests, since this fact involves not only the individual and their
      families, but the entire population. Besides being also necessary to make a
      reflection on how this information from the human genome will be used, for good
      or bad. The objective of this review was to bring the light of knowledge, data on
      characteristics of the ethical application of molecular biology, linking it with 
      the rights of human beings. After studying literature, it might be observed that 
      the Human Genome Project has generated several possibilities, such as the
      identification of genes associated with diseases with synergistic properties, but
      sometimes modifying behavior to genetically intervene in humans, bringing
      benefits or social harm. The big challenge is to decide what humanity wants on
      this giant leap.
FAU - Goulart, Maria Carolina Vaz
AU  - Goulart MC
AD  - Universidade de Sao Paulo, Bauru, SP, Brazil. mariacarolina@usp.br
FAU - Iano, Flavia Godoy
AU  - Iano FG
FAU - Silva, Paulo Mauricio
AU  - Silva PM
FAU - Sales-Peres, Silvia Helena de Carvalho
AU  - Sales-Peres SH
FAU - Sales-Peres, Arsenio
AU  - Sales-Peres A
LA  - por
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Manipulacao do genoma humano: etica e direito.
PL  - Brazil
TA  - Cien Saude Colet
JT  - Ciencia & saude coletiva
JID - 9713483
SB  - IM
MH  - Genetics/*ethics/*legislation & jurisprudence
MH  - *Genome, Human
MH  - Humans
EDAT- 2010/08/05 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/07/20 06:00
PHST- 2007/11/01 00:00 [received]
PHST- 2007/12/05 00:00 [accepted]
PHST- 2010/07/20 06:00 [entrez]
PHST- 2010/08/05 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - S1413-81232010000700082 [pii]
AID - 10.1590/s1413-81232010000700082 [doi]
PST - ppublish
SO  - Cien Saude Colet. 2010 Jun;15 Suppl 1:1709-13. doi:
      10.1590/s1413-81232010000700082.


PMID- 20640331
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20190907
IS  - 1678-4561 (Electronic)
IS  - 1413-8123 (Linking)
VI  - 15 Suppl 1
DP  - 2010 Jun
TI  - [Discourses about health risk behaviour and the moralization of the everyday
      life].
PG  - 1699-708
LID - S1413-81232010000700081 [pii]
AB  - The text analyses critically the polarity between discourses about healthy life
      styles and the sedentariness in the context of new technologies for health
      information research and dissemination. We argue that the techno-scientific
      rationality has grown an 'economy of trues' which, on the perspective of
      conducting to safe life styles, has prescribed a normative ideal of self
      discipline which tends to generate distress and consumerism of artifacts of
      burning calories. In the hegemonic production of systems of truth, sedentariness 
      has been seen as a kind of unhealthy behavior that is ranked as moral failure.
      Emphasis is given about the multiple discourses embracing life styles and risk,
      taken as biopolitics devices imbricated in the communication processes in health,
      which has to be lightened up for their ethics and politics implications. The
      spectacularization of life styles associated to the consumption and the
      production of narratives that have badly influenced our culture, making bigger
      the distance of a socially possible notion of health. We discussed the regulatory
      essence of such a symbolic reference in the construction of knowledge systems
      that have been (re)defined what is to be healthy, normal and unhealthy.
FAU - Bagrichevsky, Marcos
AU  - Bagrichevsky M
AD  - Centro de Educacao Fisica e Desportos, Universidade Federal do Espirito Santo,
      Vitoria, ES, Brazil. marcos_bagrichevsky@yahoo.com.br
FAU - Castiel, Luis David
AU  - Castiel LD
FAU - Vasconcellos-Silva, Paulo Roberto
AU  - Vasconcellos-Silva PR
FAU - Estevao, Adriana
AU  - Estevao A
LA  - por
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
TT  - Discursos sobre comportamento de risco a saude e a moralizacao da vida cotidiana.
PL  - Brazil
TA  - Cien Saude Colet
JT  - Ciencia & saude coletiva
JID - 9713483
SB  - IM
MH  - Humans
MH  - *Life Style
MH  - *Morals
MH  - *Risk-Taking
MH  - Sedentary Behavior
EDAT- 2010/08/05 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/07/20 06:00
PHST- 2008/07/12 00:00 [received]
PHST- 2008/12/29 00:00 [accepted]
PHST- 2010/07/20 06:00 [entrez]
PHST- 2010/08/05 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - S1413-81232010000700081 [pii]
AID - 10.1590/s1413-81232010000700081 [doi]
PST - ppublish
SO  - Cien Saude Colet. 2010 Jun;15 Suppl 1:1699-708. doi:
      10.1590/s1413-81232010000700081.


PMID- 20640329
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20190907
IS  - 1678-4561 (Electronic)
IS  - 1413-8123 (Linking)
VI  - 15 Suppl 1
DP  - 2010 Jun
TI  - [The ethics of qualitative research in health: the said and the unsaid in the
      scientific production].
PG  - 1673-84
LID - S1413-81232010000700079 [pii]
AB  - This study investigated the ethics of qualitative research by using bibliographic
      research. Data were collected in scientific articles from a Brazilian journal of 
      collective health and the access to the sources was electronic. It were analyzed 
      117 articles of qualitative research which corresponded to 23.49% of the total
      production of the journal from 01/1998 to 03/2007. The information collected was 
      organized considering the identification, themes/object, theoretical referential,
      methodology and ethical aspects involved. The analysis proposed a discussion
      based on what the researchers express about ethics on their qualitative studies
      when it comes to two different kinds of relation: between the researchers and
      their research-subject and with their co-workers. The conclusions brought up many
      issues to be discussed on the daily routine of the research activity and that
      demands exposition and openness to criticism. There is also an urge to think what
      the "said" and the "unsaid" can reveal underneath the obedience to the rules,
      launching to the process of maturing and to the theoretical consistence of the
      researchers, especially in the ethical dimension of the researching activity. A
      huge part of those challenges are of direct responsibility of the institutions
      which are in charge of the researcher's formation.
FAU - Ramos, Flavia Regina Souza
AU  - Ramos FR
AD  - Departamento de Enfermagem, Centro de Ciencias da Saude, Universitario Trindade, 
      Florianopolis, SC, Brazil. flaviar@ccs.ufsc.br
FAU - Finkler, Mirelle
AU  - Finkler M
FAU - Goncalves, Evelise Ribeiro
AU  - Goncalves ER
FAU - Caetano, Joao Carlos
AU  - Caetano JC
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - A eticidade na pesquisa qualitativa em saude: o dito e o nao dito nas producoes
      cientificas.
PL  - Brazil
TA  - Cien Saude Colet
JT  - Ciencia & saude coletiva
JID - 9713483
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Brazil
MH  - *Qualitative Research
EDAT- 2010/08/05 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/07/20 06:00
PHST- 2007/07/27 00:00 [received]
PHST- 2007/12/20 00:00 [accepted]
PHST- 2010/07/20 06:00 [entrez]
PHST- 2010/08/05 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - S1413-81232010000700079 [pii]
AID - 10.1590/s1413-81232010000700079 [doi]
PST - ppublish
SO  - Cien Saude Colet. 2010 Jun;15 Suppl 1:1673-84. doi:
      10.1590/s1413-81232010000700079.


PMID- 20640272
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20190907
IS  - 1678-4561 (Electronic)
IS  - 1413-8123 (Linking)
VI  - 15 Suppl 1
DP  - 2010 Jun
TI  - [The philosophical and historical bases of the care and the call of sexual
      partners in HIV/AIDS as a form to look after].
PG  - 1143-8
LID - S1413-81232010000700022 [pii]
AB  - This is an article in which we discuss the concept of the care according to the
      perspective of the philosophy, linking with the practice of the nurses, who
      appropriates themselves of this concept to substantiate their professional
      practice. We defend that a way to look after with ethics can be carried out when 
      the professional call upon the partners of the HIV/AIDS infected patients. We
      believe that this moment is very delicate and deserves to be argued and to be
      institutionalized by the professional team that carries out the specialized
      attendance in HIV/AIDS.
FAU - Luz, Priscilla Mesquita
AU  - Luz PM
AD  - Departamento de Enfermagem, Centro de Ciencias da Saude, Universidade Estadual do
      Ceara, Fortaleza, CE, Brazil. priscillaluz@gmail.com
FAU - Miranda, Karla Correa Lima
AU  - Miranda KC
LA  - por
PT  - English Abstract
PT  - Historical Article
PT  - Journal Article
TT  - As bases filosoficas e historicas do cuidado e a convocacao de parceiros sexuais 
      em HIV/aids como forma de cuidar.
PL  - Brazil
TA  - Cien Saude Colet
JT  - Ciencia & saude coletiva
JID - 9713483
SB  - IM
MH  - *Acquired Immunodeficiency Syndrome/nursing
MH  - Brazil
MH  - *Contact Tracing
MH  - HIV Infections/nursing
MH  - History of Nursing
MH  - History, 20th Century
MH  - Humans
MH  - Philosophy, Medical
MH  - *Sexual Partners
EDAT- 2010/08/05 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/07/20 06:00
PHST- 2007/08/06 00:00 [received]
PHST- 2007/10/29 00:00 [accepted]
PHST- 2010/07/20 06:00 [entrez]
PHST- 2010/08/05 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - S1413-81232010000700022 [pii]
AID - 10.1590/s1413-81232010000700022 [doi]
PST - ppublish
SO  - Cien Saude Colet. 2010 Jun;15 Suppl 1:1143-8. doi:
      10.1590/s1413-81232010000700022.


PMID- 20680469
OWN - NLM
STAT- MEDLINE
DCOM- 20110128
LR  - 20211020
IS  - 1572-8633 (Electronic)
IS  - 1386-7423 (Linking)
VI  - 13
IP  - 4
DP  - 2010 Nov
TI  - The cultural context of patient's autonomy and doctor's duty: passive euthanasia 
      and advance directives in Germany and Israel.
PG  - 363-9
LID - 10.1007/s11019-010-9262-3 [doi]
AB  - The moral discourse surrounding end-of-life (EoL) decisions is highly complex,
      and a comparison of Germany and Israel can highlight the impact of cultural
      factors. The comparison shows interesting differences in how patient's autonomy
      and doctor's duties are morally and legally related to each other with respect to
      the withholding and withdrawing of medical treatment in EoL situations. Taking
      the statements of two national expert ethics committees on EoL in Israel and
      Germany (and their legal outcome) as an example of this discourse, we describe
      the similarity of their recommendations and then focus on the differences,
      including the balancing of ethical principles, what is identified as a problem,
      what social role professionals play, and the influence of history and religion.
      The comparison seems to show that Israel is more restrictive in relation to
      Germany, in contrast with previous bioethical studies in the context of the moral
      and legal discourse regarding the beginning of life, in which Germany was
      characterized as far more restrictive. We reflect on the ambivalence of the
      cultural reasons for this difference and its expression in various dissenting
      views on passive euthanasia and advance directives, and conclude with a comment
      on the difficulty in classifying either stance as more or less restrictive.
FAU - Schicktanz, Silke
AU  - Schicktanz S
AD  - Department of Medical Ethics and History of Medicine, University Medical Center
      Gottingen, Gottingen, Germany. silke.schicktanz@medizin.uni-goettingen.de
FAU - Raz, Aviad
AU  - Raz A
FAU - Shalev, Carmel
AU  - Shalev C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Med Health Care Philos
JT  - Medicine, health care, and philosophy
JID - 9815900
SB  - IM
MH  - Advance Directives/*ethics/ethnology/legislation & jurisprudence/psychology
MH  - *Bioethics
MH  - Cross-Cultural Comparison
MH  - Euthanasia, Passive/*ethics/legislation & jurisprudence/psychology
MH  - Germany
MH  - Humans
MH  - Israel
MH  - Moral Obligations
MH  - Palliative Care/ethics
MH  - Patient Rights/*ethics/legislation & jurisprudence
MH  - *Personal Autonomy
MH  - Religion and Medicine
MH  - Value of Life
PMC - PMC2949555
EDAT- 2010/08/04 06:00
MHDA- 2011/02/01 06:00
CRDT- 2010/08/04 06:00
PHST- 2010/08/04 06:00 [entrez]
PHST- 2010/08/04 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
AID - 10.1007/s11019-010-9262-3 [doi]
PST - ppublish
SO  - Med Health Care Philos. 2010 Nov;13(4):363-9. doi: 10.1007/s11019-010-9262-3.


PMID- 20680438
OWN - NLM
STAT- MEDLINE
DCOM- 20101130
LR  - 20141120
IS  - 1573-2770 (Electronic)
IS  - 0091-0562 (Linking)
VI  - 46
IP  - 1-2
DP  - 2010 Sep
TI  - Partnering with children diagnosed with mental health issues: contributions of a 
      sociology of childhood perspective to participatory action research.
PG  - 84-99
LID - 10.1007/s10464-010-9323-z [doi]
AB  - This paper explores the use of participatory action research (PAR) with children 
      diagnosed with mental health issues. We argue that critiques from the sociology
      of childhood are useful for guiding PAR with children. First, we describe and
      critique values and assumptions that underlie research and practice with children
      who experience mental health issues. Second, we outline key qualities of the
      sociology of childhood, discuss their implications for PAR with children
      diagnosed with mental health issues, and touch on ethical issues. Five themes are
      explored: (a) values, (b) ontology/epistemology, (c) views about children, (d)
      agency/power in children's relationships with adults, and (e) intervention/change
      focus. We conclude by encouraging community psychologists to consider PAR with
      children diagnosed with mental health issues.
FAU - Liegghio, Maria
AU  - Liegghio M
AD  - Faculty of Social Work, Wilfrid Laurier University, Waterloo, Ontario, Canada.
      lieg0067@wlu.ca
FAU - Nelson, Geoffrey
AU  - Nelson G
FAU - Evans, Scot D
AU  - Evans SD
LA  - eng
PT  - Journal Article
PL  - England
TA  - Am J Community Psychol
JT  - American journal of community psychology
JID - 0364535
SB  - IM
MH  - Adult
MH  - Behavioral Research/methods
MH  - Child
MH  - Child Psychiatry/ethics/*methods
MH  - Community Psychiatry/ethics/*methods
MH  - Community-Based Participatory Research/ethics/*methods
MH  - Humans
MH  - Mental Disorders/*psychology
MH  - Mental Health
MH  - Psychology, Child
MH  - Sociology, Medical/methods
EDAT- 2010/08/04 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/04 06:00
PHST- 2010/08/04 06:00 [entrez]
PHST- 2010/08/04 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1007/s10464-010-9323-z [doi]
PST - ppublish
SO  - Am J Community Psychol. 2010 Sep;46(1-2):84-99. doi: 10.1007/s10464-010-9323-z.


PMID- 20680423
OWN - NLM
STAT- MEDLINE
DCOM- 20110103
LR  - 20220408
IS  - 1573-3599 (Electronic)
IS  - 1059-7700 (Linking)
VI  - 19
IP  - 5
DP  - 2010 Oct
TI  - Biobanks: importance, implications and opportunities for genetic counselors.
PG  - 423-9
LID - 10.1007/s10897-010-9305-1 [doi]
AB  - Biobanks are collections of human biological tissue specimens and related health 
      data. Biobank research hopes to provide novel insights into the genetic component
      of disease, ultimately leading to a more personalized approach to healthcare.
      However, biobanks have sparked debate due to the ethical, legal, and social
      implications surrounding utilization of population samples and data. These
      controversies include issues of consent, privacy and confidentiality, return of
      results and data-sharing. This paper provides an overview of the different types 
      and scope of biobanks and an examination of the most pertinent ethical, legal and
      social considerations surrounding such research, as well as how some of these
      concerns are being addressed. The paper finishes with a discussion of the
      relevance of biobanks to the genetic counseling field and concludes that genetic 
      counselors are in a position to make a unique, educated and practical
      contribution to the ongoing dialogue and direction of biobank research.
FAU - Hawkins, Alice K
AU  - Hawkins AK
AD  - Department of Medical Genetics, University of British Columbia, Vancouver, BC,
      Canada. alicehaw@interchange.ubc.ca
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100803
PL  - United States
TA  - J Genet Couns
JT  - Journal of genetic counseling
JID - 9206865
SB  - IM
MH  - Ethics
MH  - *Genetic Counseling
MH  - Humans
MH  - *Tissue Banks
MH  - Workforce
EDAT- 2010/08/04 06:00
MHDA- 2011/01/05 06:00
CRDT- 2010/08/04 06:00
PHST- 2010/02/03 00:00 [received]
PHST- 2010/05/04 00:00 [accepted]
PHST- 2010/08/04 06:00 [entrez]
PHST- 2010/08/04 06:00 [pubmed]
PHST- 2011/01/05 06:00 [medline]
AID - 10.1007/s10897-010-9305-1 [doi]
PST - ppublish
SO  - J Genet Couns. 2010 Oct;19(5):423-9. doi: 10.1007/s10897-010-9305-1. Epub 2010
      Aug 3.


PMID- 20679971
OWN - NLM
STAT- MEDLINE
DCOM- 20100903
LR  - 20191210
IS  - 1357-6321 (Print)
IS  - 1357-6321 (Linking)
VI  - 16
IP  - 5
DP  - 2010 May
TI  - How much compassion have I left? An exploration of occupational stress among
      children's palliative care nurses.
PG  - 233-40
AB  - Nursing is a stressful occupation. While children's palliative care nurses
      encounter many of the stressors in common with other nurses, this unique context 
      of care generates specific aspects of stress that warrant further examination.
      This qualitative study explores the experiences of stress in nurses providing
      children's palliative care in one region of the UK. In total, four focus groups
      took place with children's hospice nurses, community children's nurses and
      children's nurse specialists based in the regional children's hospital. The focus
      groups were taped, transcribed and analysed through the application of Newell and
      Burnard's thematic content analysis methodology. Four core themes emerged: work
      demands; relationships, maintaining control, and support and roles. Of particular
      note were stressors associated with the sub-themes of relationships, emotional
      demands and ethical conflicts. Conclusions illustrating how individuals and
      organizations may reduce the impact of stress in nurses contributing to the
      palliative care of children and their families are made.
FAU - McCloskey, Sharon
AU  - McCloskey S
AD  - Northern Ireland Children's Hospice, Northern Ireland.
FAU - Taggart, Laurence
AU  - Taggart L
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Palliat Nurs
JT  - International journal of palliative nursing
JID - 9506762
MH  - *Attitude of Health Personnel
MH  - Burnout, Professional/*psychology
MH  - Conflict, Psychological
MH  - *Empathy
MH  - Focus Groups
MH  - Humans
MH  - Northern Ireland
MH  - Nurse's Role/psychology
MH  - Nurse-Patient Relations
MH  - Nursing Methodology Research
MH  - Nursing Staff/ethics/organization & administration/*psychology
MH  - Nursing, Supervisory/organization & administration
MH  - *Palliative Care/ethics/organization & administration/psychology
MH  - *Pediatric Nursing/ethics/organization & administration
MH  - Professional Autonomy
MH  - Professional-Family Relations
MH  - Qualitative Research
MH  - Quality of Health Care
MH  - Social Support
MH  - Workload/psychology
EDAT- 2010/08/04 06:00
MHDA- 2010/09/04 06:00
CRDT- 2010/08/04 06:00
PHST- 2010/08/04 06:00 [entrez]
PHST- 2010/08/04 06:00 [pubmed]
PHST- 2010/09/04 06:00 [medline]
AID - 10.12968/ijpn.2010.16.5.48144 [doi]
PST - ppublish
SO  - Int J Palliat Nurs. 2010 May;16(5):233-40. doi: 10.12968/ijpn.2010.16.5.48144.


PMID- 20679970
OWN - NLM
STAT- MEDLINE
DCOM- 20100903
LR  - 20191210
IS  - 1357-6321 (Print)
IS  - 1357-6321 (Linking)
VI  - 16
IP  - 5
DP  - 2010 May
TI  - Community nurses' experiences of ethical dilemmas in palliative care: a Swedish
      study.
PG  - 224-31
AB  - AIM: The aim of this study was to highlight community nurses' experiences of
      ethical dilemmas in palliative care. BACKGROUND: There are many studies on
      palliative care but research on how community nurses experience ethical dilemmas 
      in palliative home care is lacking. The ethical dilemmas to which these nurses
      are exposed seriously challenge their ethical competence. METHOD: Seven community
      nurses described their experiences of ethical dilemmas in palliative home care.
      The data was analysed by means of qualitative content analysis. FINDINGS: The
      core themes that emerged were: powerlessness, frustration, and concern in
      relation to ethical dilemmas in palliative care. The nurses were motivated and
      felt responsibility for their patients' end of life, and their relatives, and
      took their duties seriously. They wanted to satisfy all parties; the patient, the
      relatives and other palliative care professionals. CONCLUSION: The study confirms
      the need for knowledge about how community nurses experience dilemmas in ethical 
      decision-making. They have the freedom to act and the willingness to make
      decisions, but they lack competence and knowledge about how their colleagues'
      experience and deal with such issues.
FAU - Karlsson, Margareta
AU  - Karlsson M
AD  - Department of Nursing, Health and Culture, University West,Trollhattan, Sweden.
FAU - Roxberg, Asa
AU  - Roxberg A
FAU - da Silva, Antonio Barbosa
AU  - da Silva AB
FAU - Berggren, Ingela
AU  - Berggren I
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Palliat Nurs
JT  - International journal of palliative nursing
JID - 9506762
MH  - *Attitude of Health Personnel
MH  - Community Health Nursing/education/*ethics/organization & administration
MH  - *Conflict, Psychological
MH  - Decision Making/ethics
MH  - Female
MH  - Frustration
MH  - Health Knowledge, Attitudes, Practice
MH  - Home Care Services/ethics/organization & administration
MH  - Humans
MH  - Models, Nursing
MH  - Models, Psychological
MH  - Motivation
MH  - Nurse's Role/psychology
MH  - Nursing Methodology Research
MH  - Nursing Staff/education/ethics/organization & administration/*psychology
MH  - Palliative Care/*ethics/organization & administration/psychology
MH  - Patient Advocacy/ethics
MH  - Power, Psychological
MH  - Professional Autonomy
MH  - Qualitative Research
MH  - Sweden
EDAT- 2010/08/04 06:00
MHDA- 2010/09/04 06:00
CRDT- 2010/08/04 06:00
PHST- 2010/08/04 06:00 [entrez]
PHST- 2010/08/04 06:00 [pubmed]
PHST- 2010/09/04 06:00 [medline]
AID - 10.12968/ijpn.2010.16.5.48143 [doi]
PST - ppublish
SO  - Int J Palliat Nurs. 2010 May;16(5):224-31. doi: 10.12968/ijpn.2010.16.5.48143.


PMID- 20679257
OWN - NLM
STAT- MEDLINE
DCOM- 20101217
LR  - 20180724
IS  - 1472-1465 (Electronic)
IS  - 0007-1250 (Linking)
VI  - 197
IP  - 2
DP  - 2010 Aug
TI  - Ethical dilemmas: should antipsychotics ever be prescribed for people with
      dementia?
PG  - 88-90
LID - 10.1192/bjp.bp.109.076307 [doi]
AB  - The use of antipsychotics for the treatment of behavioural and psychological
      symptoms of dementia (BPSD) is controversial. Antipsychotics cause harm and
      evidence-based guidelines advise against their use. We argue that antipsychotics 
      may be justified using a palliative model: by reducing severe distress in those
      whose life expectancy is short.
FAU - Treloar, Adrian
AU  - Treloar A
FAU - Crugel, Monica
AU  - Crugel M
FAU - Prasanna, Aparna
AU  - Prasanna A
FAU - Solomons, Luke
AU  - Solomons L
FAU - Fox, Chris
AU  - Fox C
FAU - Paton, Carol
AU  - Paton C
FAU - Katona, Cornelius
AU  - Katona C
LA  - eng
PT  - Editorial
PL  - England
TA  - Br J Psychiatry
JT  - The British journal of psychiatry : the journal of mental science
JID - 0342367
RN  - 0 (Antipsychotic Agents)
SB  - IM
CIN - Br J Psychiatry. 2010 Dec;197(6):501-2; author reply 502. PMID: 21119160
CIN - Br J Psychiatry. 2010 Dec;197(6):501; author reply 502. PMID: 21119161
MH  - Antipsychotic Agents/adverse effects/*therapeutic use
MH  - Dementia/*drug therapy/psychology
MH  - Female
MH  - Humans
MH  - Male
MH  - Palliative Care/*ethics
EDAT- 2010/08/04 06:00
MHDA- 2010/12/18 06:00
CRDT- 2010/08/04 06:00
PHST- 2010/08/04 06:00 [entrez]
PHST- 2010/08/04 06:00 [pubmed]
PHST- 2010/12/18 06:00 [medline]
AID - S0007125000252768 [pii]
AID - 10.1192/bjp.bp.109.076307 [doi]
PST - ppublish
SO  - Br J Psychiatry. 2010 Aug;197(2):88-90. doi: 10.1192/bjp.bp.109.076307.


PMID- 20679122
OWN - NLM
STAT- MEDLINE
DCOM- 20101019
LR  - 20130424
IS  - 1364-503X (Print)
IS  - 1364-503X (Linking)
VI  - 368
IP  - 1926
DP  - 2010 Sep 13
TI  - Privacy compliance and enforcement on European healthgrids: an approach through
      ontology.
PG  - 4057-72
LID - 10.1098/rsta.2010.0169 [doi]
AB  - The sharing of medical data between different healthcare organizations in Europe 
      must comply with the legislation of the Member State where the data were
      originally collected. These legal requirements may differ from one state to
      another. Privacy requirements such as patient consent may be subject to
      conflicting conditions between different national frameworks as well as between
      different legal and ethical frameworks within a single Member State. These
      circumstances have made the compliance management process in European healthgrids
      very challenging. In this paper, we present an approach to tackle these issues by
      relying on several technologies in the semantic Web stack. Our work suggests a
      direct mapping from high-level legislation on privacy and data protection to
      operational-level privacy-aware controls. Additionally, we suggest an
      architecture for the enforcement of these controls on access control models
      adopted in healthgrid security infrastructures.
FAU - Rahmouni, Hanene Boussi
AU  - Rahmouni HB
AD  - Bristol Institute of Technology, UWE, Frenchay Campus, Coldharbour Lane, Bristol 
      BS16 1QY, UK. hanene2.rahmouni@uwe.ac.uk
FAU - Solomonides, Tony
AU  - Solomonides T
FAU - Mont, Marco Casassa
AU  - Mont MC
FAU - Shiu, Simon
AU  - Shiu S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Philos Trans A Math Phys Eng Sci
JT  - Philosophical transactions. Series A, Mathematical, physical, and engineering
      sciences
JID - 101133385
SB  - IM
MH  - Computer Systems
MH  - Confidentiality/ethics/*legislation & jurisprudence
MH  - European Union
MH  - Humans
MH  - Information Dissemination/ethics/legislation & jurisprudence
MH  - Internet
MH  - Legislation, Medical
EDAT- 2010/08/04 06:00
MHDA- 2010/10/20 06:00
CRDT- 2010/08/04 06:00
PHST- 2010/08/04 06:00 [entrez]
PHST- 2010/08/04 06:00 [pubmed]
PHST- 2010/10/20 06:00 [medline]
AID - 368/1926/4057 [pii]
AID - 10.1098/rsta.2010.0169 [doi]
PST - ppublish
SO  - Philos Trans A Math Phys Eng Sci. 2010 Sep 13;368(1926):4057-72. doi:
      10.1098/rsta.2010.0169.


PMID- 20678770
OWN - NLM
STAT- MEDLINE
DCOM- 20110524
LR  - 20110131
IS  - 1873-491X (Electronic)
IS  - 0020-7489 (Linking)
VI  - 48
IP  - 2
DP  - 2011 Feb
TI  - "Like a trip to McDonalds": a grounded theory study of patient experiences of day
      surgery.
PG  - 165-74
LID - 10.1016/j.ijnurstu.2010.07.007 [doi]
AB  - BACKGROUND: The amount and complexity of (ambulatory) day surgery is rapidly
      expanding internationally. Nurses have a responsibility to provide quality care
      for day surgery patients. To do this they must understand all aspects of the
      patient experience. There is dearth of research into day surgery using a
      sociological frame of reference. OBJECTIVE: The study investigated patients'
      experiences of day surgery using a sociological frame of reference. DESIGN: A
      qualitative study using the grounded theory approach was used. SETTING: The study
      was based in two day surgery units in two urban public hospitals in the United
      Kingdom. PARTICIPANTS: 145 patients aged 18-70 years and 100 carers were
      purposely selected from the orthopaedic, ear nose and throat and general surgical
      lists. They were all English speaking and were of varied socio-economic
      background. METHODS: The data was collected from 2004 to 2006. Semi-structured
      interviews were conducted on three occasions: before surgery, 48 h following
      surgery and one month following discharge. Permission was received from the Local
      Research Ethics Committee. Analysis of the data involved line-by-line analysis,
      compilation of key words and phrases (codes) and constant comparison of the codes
      until categories emerged. FINDINGS: Patients liked day surgery and placed it
      within the wider societal context of efficiency and speed. Time was a major issue
      for them. They wished surgery, like all other aspects of their life to be a
      speedy process. They likened it to a McDonald's experience with its emphasis on
      speed, predictability and control. CONCLUSION: This study throws new light on
      patient experiences and offers an understanding of day surgery against a western 
      culture which emphasises the importance of speed and efficiency. It is a popular 
      choice for patients but at times it can be seen to be a mechanistic way of
      providing care. The implications for nurses to provide education and information 
      to add to the quality of the patient experience are discussed.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Mottram, Anne
AU  - Mottram A
AD  - School of Nursing and Health Visiting, Mary Seacole Building, University of
      Salford, Frederick Road, Salford M6 6PU, United Kingdom. a.mottram@salford.ac.uk
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100803
PL  - England
TA  - Int J Nurs Stud
JT  - International journal of nursing studies
JID - 0400675
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Ambulatory Surgical Procedures
MH  - Humans
MH  - Middle Aged
MH  - *Models, Psychological
MH  - Patients/*psychology
MH  - Young Adult
EDAT- 2010/08/04 06:00
MHDA- 2011/05/25 06:00
CRDT- 2010/08/04 06:00
PHST- 2010/02/28 00:00 [received]
PHST- 2010/07/05 00:00 [revised]
PHST- 2010/07/07 00:00 [accepted]
PHST- 2010/08/04 06:00 [entrez]
PHST- 2010/08/04 06:00 [pubmed]
PHST- 2011/05/25 06:00 [medline]
AID - S0020-7489(10)00218-X [pii]
AID - 10.1016/j.ijnurstu.2010.07.007 [doi]
PST - ppublish
SO  - Int J Nurs Stud. 2011 Feb;48(2):165-74. doi: 10.1016/j.ijnurstu.2010.07.007. Epub
      2010 Aug 3.


PMID- 20678461
OWN - NLM
STAT- MEDLINE
DCOM- 20101221
LR  - 20100824
IS  - 1873-1570 (Electronic)
IS  - 0300-9572 (Linking)
VI  - 81
IP  - 9
DP  - 2010 Sep
TI  - Scientific, legal, and ethical challenges of end-of-life organ procurement in
      emergency medicine.
PG  - 1069-78
LID - 10.1016/j.resuscitation.2010.05.007 [doi]
AB  - AIM: We review (1) scientific evidence questioning the validity of declaring
      death and procuring organs in heart-beating (i.e., neurological standard of
      death) and non-heart-beating (i.e., circulatory-respiratory standard of death)
      donation; (2) consequences of collaborative programs realigning hospital policies
      to maximize access of procurement coordinators to critically and terminally ill
      patients as potential donors on arrival in emergency departments; and (3) ethical
      and legal ramifications of current practices of organ procurement on patients and
      their families. DATA SOURCES: Relevant publications in peer-reviewed journals and
      government websites. RESULTS: Scientific evidence undermines the biological
      criteria of death that underpin the definition of death in heart-beating (i.e.,
      neurological standard) and non-heart-beating (i.e., circulatory-respiratory
      standard) donation. Philosophical reinterpretation of the neurological and
      circulatory-respiratory standards in the death statute, to avoid the appearance
      of organ procurement as an active life-ending intervention, lacks public and
      medical consensus. Collaborative programs bundle procurement coordinators
      together with hospital staff for a team-huddle and implement a quality
      improvement tool for a Rapid Assessment of Hospital Procurement Barriers in
      Donation. Procurement coordinators have access to critically ill patients during 
      the course of medical treatment with no donation consent and with family or
      surrogates unaware of their roles. How these programs affect the medical care of 
      these patients has not been studied. CONCLUSIONS: Policies enforcing end-of-life 
      organ procurement can have unintended consequences: (1) erosion of care in the
      patient's best interests, (2) lack of transparency, and (3) ethical and legal
      ramifications of flawed standards of declaring death.
CI  - Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Rady, Mohamed Y
AU  - Rady MY
AD  - Department of Critical Care Medicine, Mayo Clinic, Phoenix, AZ 85054, USA.
      Rady.Mohamed@mayo.edu
FAU - Verheijde, Joseph L
AU  - Verheijde JL
FAU - McGregor, Joan L
AU  - McGregor JL
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100617
PL  - Ireland
TA  - Resuscitation
JT  - Resuscitation
JID - 0332173
SB  - IM
CIN - Resuscitation. 2010 Sep;81(9):1061-2. PMID: 20650558
MH  - Brain Death
MH  - *Critical Illness
MH  - Death
MH  - Emergency Medicine/*ethics/*methods
MH  - Ethics, Professional
MH  - Humans
MH  - Informed Consent
MH  - Quality of Health Care
MH  - *Science
MH  - Terminology as Topic
MH  - Tissue and Organ Procurement/*ethics/*legislation & jurisprudence
EDAT- 2010/08/04 06:00
MHDA- 2010/12/22 06:00
CRDT- 2010/08/04 06:00
PHST- 2010/02/23 00:00 [received]
PHST- 2010/05/10 00:00 [revised]
PHST- 2010/05/12 00:00 [accepted]
PHST- 2010/08/04 06:00 [entrez]
PHST- 2010/08/04 06:00 [pubmed]
PHST- 2010/12/22 06:00 [medline]
AID - S0300-9572(10)00278-9 [pii]
AID - 10.1016/j.resuscitation.2010.05.007 [doi]
PST - ppublish
SO  - Resuscitation. 2010 Sep;81(9):1069-78. doi: 10.1016/j.resuscitation.2010.05.007. 
      Epub 2010 Jun 17.


PMID- 20678203
OWN - NLM
STAT- MEDLINE
DCOM- 20110203
LR  - 20211020
IS  - 1471-2407 (Electronic)
IS  - 1471-2407 (Linking)
VI  - 10
DP  - 2010 Aug 2
TI  - Variations in the quality and costs of end-of-life care, preferences and
      palliative outcomes for cancer patients by place of death: the QUALYCARE study.
PG  - 400
LID - 10.1186/1471-2407-10-400 [doi]
AB  - BACKGROUND: Emerging trends and new policies suggest that more cancer patients
      might die at home in the future. However, not all have equal chances of achieving
      this. Furthermore, there is lack of evidence to support that those who die at
      home experience better care and a better death than those who die as inpatients. 
      The QUALYCARE study aims to examine variations in the quality and costs of
      end-of-life care, preferences and palliative outcomes associated with dying at
      home or in an institution for cancer patients. METHODS/DESIGN: Mortality
      followback survey (with a nested case-control study of home vs. hospital deaths) 
      conducted with bereaved relatives of cancer patients in four Primary Care Trusts 
      in London. Potential participants are identified from death registrations and
      approached by the Office for National Statistics in complete confidence. Data are
      collected via a postal questionnaire to identify the informal and formal care
      received in the three months before death and the associated costs, relatives'
      satisfaction with care, and palliative outcomes for the patients and their
      relatives. A well-established questionnaire to measure relatives' views on the
      care integrates four brief and robust tools - the Client Service Receipt
      Inventory, the Palliative Outcome Scale, the EQ-5 D and the Texas Revised
      Inventory of Grief. Further questions assess patients and relatives' preferences 
      for place of death. The survey aims to include 500 bereaved relatives (140 who
      experienced a home death, 205 a hospital death, 115 a hospice death and 40 a
      nursing home death). Bivariate and multivariate analyses will explore differences
      in place of death and place of end-of-life care, in preferences for place of
      death, patients' palliative outcomes and relatives' bereavement outcomes, in
      relation to place of death. Factors influencing death at home and the costs of
      end-of-life care by place of death will be identified. DISCUSSION: Collecting
      data on end-of-life care retrospectively from bereaved relatives has ethical,
      practical and scientific challenges. QUALYCARE has been carefully designed to
      address these challenges in a robust and ethically sound population-based survey.
      By discovering variations in the underlying individual reality of place of death 
      for people dying from cancer and their families, this study will advance our
      understanding of end-of-life care and, we hope, improve care for cancer patients 
      and their families in the future. TRIAL REGISTRATION: National Institute of
      Health Research (NIHR) Clinical Research Network Portfolio. UKCRN7041.
FAU - Gomes, Barbara
AU  - Gomes B
AD  - Department of Palliative Care, King's College London, Cicely Saunders Institute, 
      Bessemer Road, London SE5 9PJ, UK. barbara.gomes@kcl.ac.uk
FAU - McCrone, Paul
AU  - McCrone P
FAU - Hall, Sue
AU  - Hall S
FAU - Koffman, Jonathan
AU  - Koffman J
FAU - Higginson, Irene J
AU  - Higginson IJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100802
PL  - England
TA  - BMC Cancer
JT  - BMC cancer
JID - 100967800
SB  - IM
MH  - Adolescent
MH  - *Attitude to Death
MH  - Case-Control Studies
MH  - Decision Making
MH  - Family/*psychology
MH  - Home Care Services/*standards
MH  - Hospitals
MH  - Humans
MH  - Neoplasms/*economics/*mortality/psychology
MH  - Palliative Care/*psychology
MH  - Pilot Projects
MH  - *Quality Assurance, Health Care
MH  - Retrospective Studies
MH  - Surveys and Questionnaires
MH  - Survival Rate
MH  - Terminal Care/*standards
MH  - Treatment Outcome
PMC - PMC2919503
EDAT- 2010/08/04 06:00
MHDA- 2011/02/04 06:00
CRDT- 2010/08/04 06:00
PHST- 2010/06/08 00:00 [received]
PHST- 2010/08/02 00:00 [accepted]
PHST- 2010/08/04 06:00 [entrez]
PHST- 2010/08/04 06:00 [pubmed]
PHST- 2011/02/04 06:00 [medline]
AID - 1471-2407-10-400 [pii]
AID - 10.1186/1471-2407-10-400 [doi]
PST - epublish
SO  - BMC Cancer. 2010 Aug 2;10:400. doi: 10.1186/1471-2407-10-400.


PMID- 20678044
OWN - NLM
STAT- MEDLINE
DCOM- 20100928
LR  - 20201230
IS  - 0025-729X (Print)
IS  - 0025-729X (Linking)
VI  - 193
IP  - 3
DP  - 2010 Aug 2
TI  - Ethical considerations in choosing a model for population-based cystic fibrosis
      carrier screening.
PG  - 157-60
AB  - Cystic fibrosis (CF) carrier testing can be used to inform reproductive decision 
      making, allowing carriers to avoid having a child with CF. A government-funded,
      population-based CF carrier screening program would allow greater equity of
      access to this test. The setting in which CF carrier screening is offered
      significantly affects the extent to which participants make well informed,
      voluntary decisions to accept or decline testing. Screening offered before
      pregnancy and in non-clinical environments better promotes participant autonomy
      than screening offered in the prenatal consultation.
FAU - Modra, Lucy J
AU  - Modra LJ
AD  - Austin Health, Melbourne, VIC, Australia. lucy.modra@austin.org.au
FAU - Massie, R John
AU  - Massie RJ
FAU - Delatycki, Martin B
AU  - Delatycki MB
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Australia
TA  - Med J Aust
JT  - The Medical journal of Australia
JID - 0400714
SB  - IM
MH  - Choice Behavior
MH  - Cystic Fibrosis/*genetics/prevention & control
MH  - *Ethics, Medical
MH  - Female
MH  - Genetic Carrier Screening/*methods
MH  - Genetic Counseling
MH  - Genetic Testing
MH  - Humans
MH  - Models, Theoretical
MH  - Pregnancy
MH  - Prenatal Diagnosis
RF  - 36
EDAT- 2010/08/04 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/08/04 06:00
PHST- 2009/06/08 00:00 [received]
PHST- 2009/12/22 00:00 [accepted]
PHST- 2010/08/04 06:00 [entrez]
PHST- 2010/08/04 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - mod10689_fm [pii]
AID - 10.5694/j.1326-5377.2010.tb03836.x [doi]
PST - ppublish
SO  - Med J Aust. 2010 Aug 2;193(3):157-60. doi: 10.5694/j.1326-5377.2010.tb03836.x.


PMID- 20677678
OWN - NLM
STAT- MEDLINE
DCOM- 20100902
LR  - 20100803
IS  - 1120-9135 (Print)
IS  - 1120-9135 (Linking)
VI  - 22
IP  - 3
DP  - 2010 May-Jun
TI  - [Research Ethics Committees in Abruzzo: criticisms and prospects for
      developments].
PG  - 263-72
AB  - The first legislative bills on Ethics Committee (EC) activity were adopted across
      the Italian Regions simultaneously (1998). This widespread implementation meant
      it was necessary to define new qualitative and quantitative standards (Decree
      Law, 12th May 2009), creating expectations about the EC's role in research and
      clinical practice and its potential to improve the quality of medical assistance.
      The present paper presents the results of a descriptive survey that maps out the 
      framework, organization and operating methods of ECs in the Abruzzo Region in
      Italy. Differences between ECs have been outlined, with special concern for
      differences in organization and way of operating. It was found that interaction
      between the EC and the experimenter is limited to the authorization phase of the 
      research protocol, with low level involvement in the planning and execution
      phases. Additionally, the exchange of information between the co-ordinating EC
      and EC practitioners is not well organized in multicentre experimentation. A
      certain amount of criticism emerged regarding those areas of activity that would 
      help to place the EC at the centre of the cultural growth process with regards to
      Bioethics and Clinical Research (e.g. education, on-line news on Bioethics
      topics).These criticisms are part of the reality of the Abruzzo Region that lacks
      economic and structural resources which penalizes EC activity.
FAU - Leuter, C
AU  - Leuter C
AD  - Dipartimento di Medicina e Sanita Pubblica, Universita degli Studi di L'Aquila.
      cinzia.leuter@cc.univaq.it
FAU - Altobelli, E
AU  - Altobelli E
FAU - di Orio, F
AU  - di Orio F
LA  - ita
PT  - English Abstract
PT  - Journal Article
TT  - I Comitati etici abruzzesi: criticita rilevate e prospettive di sviluppo.
PL  - Italy
TA  - Ann Ig
JT  - Annali di igiene : medicina preventiva e di comunita
JID - 9002865
SB  - IM
MH  - *Ethics Committees, Research
MH  - Italy
EDAT- 2010/08/04 06:00
MHDA- 2010/09/03 06:00
CRDT- 2010/08/04 06:00
PHST- 2010/08/04 06:00 [entrez]
PHST- 2010/08/04 06:00 [pubmed]
PHST- 2010/09/03 06:00 [medline]
PST - ppublish
SO  - Ann Ig. 2010 May-Jun;22(3):263-72.


PMID- 20677677
OWN - NLM
STAT- MEDLINE
DCOM- 20100902
LR  - 20100803
IS  - 1120-9135 (Print)
IS  - 1120-9135 (Linking)
VI  - 22
IP  - 3
DP  - 2010 May-Jun
TI  - [Organ allocation. Ethical issues].
PG  - 253-61
AB  - The criteria for allocating organs are one of the most debated ethical issue in
      the transplantation programs. The article examines some rules and principles
      followed by "Nord Italia Transplant program", summarized in its Principles'
      Charter and explained in a recent interdisciplinary book. General theories of
      justice and their application to individual clinical cases are commented and
      evaluated, in order to foster a public, democratic, transparent debate among
      professionals and citizens, scientific associations and customers' organizations.
      Some specific moral dilemmas are focused regarding the concepts of proportionate 
      treatment, unselfish donation by living persons, promotion of local institutions 
      efficiency.
FAU - Cattorini, P
AU  - Cattorini P
AD  - Dipartimento di Medicina e Sanita Pubblica, Cattedra di Bioetica, Universita
      Studi Insubria, Varese. paolo.cattorini@uninsubria.it
LA  - ita
PT  - English Abstract
PT  - Journal Article
TT  - L'assegnazione degli organi. Aspetti etici.
PL  - Italy
TA  - Ann Ig
JT  - Annali di igiene : medicina preventiva e di comunita
JID - 9002865
SB  - IM
MH  - Humans
MH  - Tissue and Organ Procurement/*ethics
EDAT- 2010/08/04 06:00
MHDA- 2010/09/03 06:00
CRDT- 2010/08/04 06:00
PHST- 2010/08/04 06:00 [entrez]
PHST- 2010/08/04 06:00 [pubmed]
PHST- 2010/09/03 06:00 [medline]
PST - ppublish
SO  - Ann Ig. 2010 May-Jun;22(3):253-61.


PMID- 20677575
OWN - NLM
STAT- MEDLINE
DCOM- 20100913
LR  - 20100803
IS  - 1827-6806 (Print)
IS  - 1827-6806 (Linking)
VI  - 11
IP  - 4
DP  - 2010 Apr
TI  - [Cardiac resynchronization therapy with defibrillation capability: considerations
      on a not yet proven therapeutic superiority].
PG  - 295-305
AB  - Cardiac resynchronization therapy (CRT) has proven a very useful tool to treat
      heart failure (HF). In HF patients with severely depressed left ventricular
      dysfunction and ventricular dyssynchrony who remain symptomatic despite optimal
      medical therapy, the "reverse remodeling" induced by CRT leads to a significant
      improvement of survival and quality of life. The addition of the
      cardioversion-defibrillation function to CRT (CRT-D) is considered a further
      beneficial effect to reduce overall mortality secondary to a decrease in sudden
      death rate. Unfortunately, the amount of this additional benefit is still
      uncertain; in particular, how much the cardioversion-defibrillation function
      contributes to prolong patient survival remains to be elucidated. Such
      uncertainty leads to a different therapeutic approach to HF patients, i.e., an
      extended or restricted use of CRT-D devices. Even the most recent guidelines do
      not provide a clear answer to this question. The present review summarizes the
      current evidence regarding efficacy, effectiveness, safety, and
      cost-effectiveness of CRT and CRT-D, and suggests some practical solutions to the
      appropriate use of CRT-D on the basis of clinical, ethical and socio-economic
      considerations.
FAU - Berisso, Massimo Zoni
AU  - Berisso MZ
AD  - Divisione di Cardiologia, Ospedale Padre A. Micone, ASL 3 Genovese, Genova.
      massimo.zoniberisso@libero.it
FAU - Canonero, Daniele
AU  - Canonero D
FAU - Caruso, Davide
AU  - Caruso D
FAU - Setti, Sergio
AU  - Setti S
FAU - Domenicucci, Stefano
AU  - Domenicucci S
LA  - ita
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Terapia di risincronizzazione cardiaca in combinazione con la funzione di
      cardioversione-defibrillazione: considerazioni su una superiorita terapeutica
      ancora da dimostrare.
PL  - Italy
TA  - G Ital Cardiol (Rome)
JT  - Giornale italiano di cardiologia (2006)
JID - 101263411
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Arrhythmias, Cardiac/therapy
MH  - Cardiac Pacing, Artificial/economics/ethics/*methods
MH  - Clinical Trials as Topic
MH  - Comorbidity
MH  - Electric Countershock/economics/ethics/*methods
MH  - Heart Failure/mortality/physiopathology/*therapy
MH  - Heart Function Tests
MH  - Humans
MH  - Meta-Analysis as Topic
MH  - Multicenter Studies as Topic
MH  - Practice Guidelines as Topic
MH  - Risk Factors
MH  - Ventricular Dysfunction, Left/mortality/*therapy
RF  - 105
EDAT- 2010/08/04 06:00
MHDA- 2010/09/14 06:00
CRDT- 2010/08/04 06:00
PHST- 2010/08/04 06:00 [entrez]
PHST- 2010/08/04 06:00 [pubmed]
PHST- 2010/09/14 06:00 [medline]
PST - ppublish
SO  - G Ital Cardiol (Rome). 2010 Apr;11(4):295-305.


PMID- 20677499
OWN - NLM
STAT- MEDLINE
DCOM- 20100913
LR  - 20100803
IS  - 1268-6034 (Print)
IS  - 1268-6034 (Linking)
IP  - 84
DP  - 2010 Jul-Aug
TI  - [What are the different prospects for positive treatment?].
PG  - 25-7
AB  - While the concept of positive treatment is undeniably fashionable, the manner in 
      which it is replacing the concept of mistreatment raises questions. What is the
      significance of this semantic development and what should be deduced from this
      new term with regard to the effective development of professional practices?
      Three different prospects appear to await the term positive treatment:
      incarnating a figure of denial, acting as an asset, or infinitely more
      preferable, bringing about a questioning of professional practices. But this
      third prospect is not without its challenges: it cannot exist without managerial 
      involvement focusing on the ethical requirements of positive treatment in terms
      of respect for people in care.
FAU - Casagrande, Alice
AU  - Casagrande A
AD  - Deleguee Nationale Qualite, Gestion des Risques, Promotion de la Bientraitance,
      Croix-Rouge Francaise, Paris. alice.casagrande@croix-rouge.fr
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Quels destins possibles pour la bientraitance?
PL  - France
TA  - Soins Gerontol
JT  - Soins. Gerontologie
JID - 9616322
MH  - *Attitude to Health
MH  - Delivery of Health Care/*standards
MH  - Ethics
MH  - Humans
MH  - Malpractice
EDAT- 2010/08/04 06:00
MHDA- 2010/09/14 06:00
CRDT- 2010/08/04 06:00
PHST- 2010/08/04 06:00 [entrez]
PHST- 2010/08/04 06:00 [pubmed]
PHST- 2010/09/14 06:00 [medline]
PST - ppublish
SO  - Soins Gerontol. 2010 Jul-Aug;(84):25-7.


PMID- 20677441
OWN - NLM
STAT- MEDLINE
DCOM- 20100830
LR  - 20191210
IS  - 0033-2674 (Print)
IS  - 0033-2674 (Linking)
VI  - 44
IP  - 2
DP  - 2010 Mar-Apr
TI  - [Neurobiological expression of the placebo effect].
PG  - 221-34
AB  - Neurobiology of the placebo effect dates back to 1978, when Levine discovered
      that its analgesic action is reversed by naloxone. Since then, various studies
      have been performed to estimate the impact of placebo on brain metabolism and
      neurotransmission in analgesia, depression or the Parkinson's disease. A number
      of involved brain structures have been pinpointed, these including nucleus
      accumbens and the anterior cingulate cortex (ACC), while the role ofopioid
      regulation has been established as significant to the process. Currently, modern 
      diagnostic appliances such as PET or fMRI are being used to determine the
      differences between placebo and drug effect on brain metabolism and,
      consequently, to identify factors responsible for therapeutic response and their 
      potential correlation with a psychological impact. Environmental conditions,
      which may result in placebo efficacy increase of seven percent per decade during 
      the last years, are also looked into. Although certain ethical and legal dilemmas
      appear considering the use of placebo, it is beyond any doubt that realising the 
      influence of expectation and conditioning on the neurobiology of the placebo
      effect, as well as on the proper therapy, should enable better patient handling
      and treatment in the future.
FAU - Grabowski, Jakub
AU  - Grabowski J
AD  - Klinika Psychiatrii Rozwojowej, Zaburzen Psychotycznych i Wieku Podeszlego AM w
      Gdansku.
FAU - Bidzan, Leszek
AU  - Bidzan L
LA  - pol
PT  - Journal Article
PT  - Review
TT  - Wykladniki neurobiologiczne efektu placebo.
PL  - Poland
TA  - Psychiatr Pol
JT  - Psychiatria polska
JID - 0103314
RN  - 0 (Opioid Peptides)
RN  - 0 (Placebos)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Analgesia/psychology
MH  - Brain/*metabolism
MH  - Brain Chemistry
MH  - Conditioning, Psychological
MH  - Dopamine/metabolism
MH  - Humans
MH  - Models, Biological
MH  - Nervous System Physiological Phenomena/*physiology
MH  - Opioid Peptides/metabolism
MH  - *Placebo Effect
MH  - Placebos/*therapeutic use
MH  - Set, Psychology
RF  - 78
EDAT- 2010/08/04 06:00
MHDA- 2010/08/31 06:00
CRDT- 2010/08/04 06:00
PHST- 2010/08/04 06:00 [entrez]
PHST- 2010/08/04 06:00 [pubmed]
PHST- 2010/08/31 06:00 [medline]
PST - ppublish
SO  - Psychiatr Pol. 2010 Mar-Apr;44(2):221-34.


PMID- 20677095
OWN - NLM
STAT- MEDLINE
DCOM- 20101110
LR  - 20220408
IS  - 2040-3445 (Electronic)
IS  - 1464-8431 (Linking)
VI  - 12
IP  - 4
DP  - 2010 Aug
TI  - Adipose-derived stem and stromal cells for cell-based therapy: current status of 
      preclinical studies and clinical trials.
PG  - 442-9
AB  - The potential use of stem cell-based therapies for the repair and regeneration of
      various tissues and organs offers a paradigm shift that may provide alternative
      therapeutic solutions for several diseases. The clinical use of either embryonic 
      stem cells or induced pluripotent stem cells remains limited because of cell
      regulations, ethical considerations and the requirement for genetic manipulation,
      although these cells are theoretically highly beneficial. Adipose-derived stem
      cells (ASCs) appear to be an ideal population of stem cells for practical
      regenerative medicine, given that they are plentiful, of autologous tissue origin
      and thus non-immunogenic, and are more easily available because of minimal
      ethical considerations. Although ASCs originate from mesodermal lineages, recent 
      preclinical studies have demonstrated that the use of ASCs in regenerative
      medicine is not limited to mesodermal tissue, but can also extend to both
      exodermal and endodermal tissues and organs. This review summarizes and discusses
      current preclinical and clinical data on the use of ASCs in regenerative medicine
      and discusses the future applications of such cell-based therapies.
FAU - Mizuno, Hiroshi
AU  - Mizuno H
AD  - Juntendo University School of Medicine, Department of Plastic and Reconstructive 
      Surgery, 2-1-1 Hongo Bunkyo-ku, Tokyo 1138421, Japan. hmizuno@juntendo.ac.jp
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Curr Opin Mol Ther
JT  - Current opinion in molecular therapeutics
JID - 100891485
SB  - IM
MH  - Adipose Tissue/*cytology
MH  - Animals
MH  - *Clinical Trials as Topic/trends
MH  - Humans
MH  - Regenerative Medicine/*methods/trends
MH  - Stem Cell Transplantation/adverse effects/*methods
MH  - Stem Cells/*cytology
MH  - Stromal Cells/*cytology/*transplantation
EDAT- 2010/08/03 06:00
MHDA- 2010/11/11 06:00
CRDT- 2010/08/03 06:00
PHST- 2010/08/03 06:00 [entrez]
PHST- 2010/08/03 06:00 [pubmed]
PHST- 2010/11/11 06:00 [medline]
PST - ppublish
SO  - Curr Opin Mol Ther. 2010 Aug;12(4):442-9.


PMID- 20677048
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20100802
IS  - 1532-7027 (Electronic)
IS  - 1041-0236 (Linking)
VI  - 25
IP  - 5
DP  - 2010 Jul
TI  - Bearing witness to the ethics of practice: storying physicians' medical mistake
      narratives.
PG  - 449-58
LID - 10.1080/10410236.2010.484876 [doi]
AB  - Medical mistakes are often referred to as the "hidden epidemic" of health because
      doctors, patients, and hospital administrators remain silent about mistakes. This
      study relies on in-depth interviews to explore how physicians story their medical
      mistake experiences. Narrative theory is used to understand how these physicians 
      story the complexity of medical mistakes, highlighting how these physicians bear 
      witness to medical mistakes by sharing and listening to medical mistake
      narratives. Moreover, this study showcases the implications of how practitioners 
      and scholars bear witness to the oft-times emotional telling and retelling of
      health narratives.
FAU - Carmack, Heather J
AU  - Carmack HJ
AD  - Department of Communication, Missouri State University, Springfield, MO 65897,
      USA. heathercarmack@missouristate.edu
LA  - eng
PT  - Journal Article
PL  - England
TA  - Health Commun
JT  - Health communication
JID - 8908762
SB  - IM
MH  - Anecdotes as Topic
MH  - Female
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - *Medical Errors
MH  - Medicine
MH  - *Narration
MH  - Physicians/*ethics
MH  - Truth Disclosure/*ethics
EDAT- 2010/08/03 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/03 06:00
PHST- 2010/08/03 06:00 [entrez]
PHST- 2010/08/03 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 924969530 [pii]
AID - 10.1080/10410236.2010.484876 [doi]
PST - ppublish
SO  - Health Commun. 2010 Jul;25(5):449-58. doi: 10.1080/10410236.2010.484876.


PMID- 20676585
OWN - NLM
STAT- MEDLINE
DCOM- 20110627
LR  - 20190606
IS  - 1678-4170 (Electronic)
IS  - 0066-782X (Linking)
VI  - 95
IP  - 3
DP  - 2010 Sep
TI  - Ethics in research with human beings: from knowledge to practice.
PG  - 289-94
LID - S0066-782X2010005000097 [pii]
AB  - BACKGROUND: In Brazil, resolution 196/96 and its amendments regulate the
      preservation of rights, respect and dignity of human beings involved in research.
      OBJECTIVE: To analyze the adequacy of Free Communications (FC) presented during
      the XVIII Congresso Pernambucano de Cardiologia to resolution 196/96. METHODS:
      During a cross-sectional study, interviews were carried out with the authors of
      the FC presented at the Congress and the abstracts of the studies were assessed
      in order to identify the need for previous approval by a Research Ethics
      Committee (REC). RESULTS: A total of 90 FC were presented and, in most of them
      (86.8%), medical files were the most commonly used source of data. Only 23.1% of 
      the FC were submitted to the assessment of a REC and 15.4% of them used a Free
      and Informed Consent Form (FICF). Among the authors whose studies were not
      assessed by a REC, 65.6% stated that this conduct was not necessary and 18% of
      them were unaware of the need to submit the study to such assessment. The written
      authorization given by the institution where the FC were carried out was not
      obtained in 56.6% of the studies. Most of the authors (80.0%) stated that they
      had never read Resolution 196/96. The proportion of FC submitted to a REC was
      significantly higher among authors that had read Resolution 196/96 (p = 0.005).
      The FC design influenced the non-submission of the studies to a REC (p < 0.001). 
      Most of the FC that were authorized by the institution where they were carried
      out were submitted to a REC (p < 0.001). CONCLUSION: Most of the FC presented at 
      the Congress did not follow the Brazilian regulations concerning the ethics in
      research.
FAU - Lima, Sandro Goncalves de
AU  - Lima SG
AD  - Departamento de Epidemiologia, Universidade Federal de Pernambuco, Brazil.
      sandrolima@cardiol.br
FAU - Lima, Tatiana Albuquerque Goncalves de
AU  - Lima TA
FAU - Macedo, Larissa Araripe de
AU  - Macedo LA
FAU - Sa, Michel Pompeu Barros de Oliveira
AU  - Sa MP
FAU - Vidal, Marcela de Lima
AU  - Vidal Mde L
FAU - Gomes, Alessandro Ferreira
AU  - Gomes AF
FAU - Oliveira, Laura Correia
AU  - Oliveira LC
FAU - Santos, Ana Maria Aguiar
AU  - Santos AM
LA  - eng
PT  - Journal Article
DEP - 20100730
PL  - Brazil
TA  - Arq Bras Cardiol
JT  - Arquivos brasileiros de cardiologia
JID - 0421031
SB  - IM
MH  - Brazil
MH  - Cardiology
MH  - *Congresses as Topic
MH  - Cross-Sectional Studies
MH  - *Ethics, Research
MH  - *Health Knowledge, Attitudes, Practice
MH  - Human Experimentation/*ethics/legislation & jurisprudence
MH  - Humans
MH  - Publishing/*standards
EDAT- 2010/08/03 06:00
MHDA- 2011/06/28 06:00
CRDT- 2010/08/03 06:00
PHST- 2009/06/19 00:00 [received]
PHST- 2009/11/24 00:00 [accepted]
PHST- 2010/08/03 06:00 [entrez]
PHST- 2010/08/03 06:00 [pubmed]
PHST- 2011/06/28 06:00 [medline]
AID - S0066-782X2010005000097 [pii]
AID - 10.1590/s0066-782x2010005000097 [doi]
PST - ppublish
SO  - Arq Bras Cardiol. 2010 Sep;95(3):289-94. doi: 10.1590/s0066-782x2010005000097.
      Epub 2010 Jul 30.


PMID- 20676352
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 2150-7740 (Print)
IS  - 2150-7759 (Linking)
VI  - 1
IP  - 1
DP  - 2010 Jan
TI  - Negotiating the Relationship Between Addiction, Ethics, and Brain Science.
PG  - 36-45
AB  - Advances in neuroscience are changing how mental health issues such as addiction 
      are understood and addressed as a brain disease. Although a brain disease model
      legitimizes addiction as a medical condition, it promotes neuro-essentialist
      thinking, categorical ideas of responsibility and free choice, and undermines the
      complexity involved in its emergence. We propose a 'biopsychosocial systems'
      model where psycho-social factors complement and interact with neurogenetics. A
      systems approach addresses the complexity of addiction and approaches free choice
      and moral responsibility within the biological, lived experience and
      socio-historical context of the individual. We examine heroin-assisted treatment 
      as an applied case example within our framework. We conclude with a discussion of
      the model and its implications for drug policy, research, addiction health care
      systems and delivery, and treatment of substance use problems.
FAU - Buchman, Daniel Z
AU  - Buchman DZ
AD  - National Core for Neuroethics, The University of British Columbia, Vancouver, BC,
      Canada.
FAU - Skinner, Wayne
AU  - Skinner W
FAU - Illes, Judy
AU  - Illes J
LA  - eng
GR  - R01 MH084282/MH/NIMH NIH HHS/United States
GR  - R01 MH084282-04A1/MH/NIMH NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - AJOB Neurosci
JT  - AJOB neuroscience
JID - 101518076
PMC - PMC2910924
MID - NIHMS167284
EDAT- 2010/08/03 06:00
MHDA- 2010/08/03 06:01
CRDT- 2010/08/03 06:00
PHST- 2010/08/03 06:00 [entrez]
PHST- 2010/08/03 06:00 [pubmed]
PHST- 2010/08/03 06:01 [medline]
AID - 10.1080/21507740903508609 [doi]
PST - ppublish
SO  - AJOB Neurosci. 2010 Jan;1(1):36-45. doi: 10.1080/21507740903508609.


PMID- 20676287
OWN - NLM
STAT- MEDLINE
DCOM- 20101019
LR  - 20211020
IS  - 0008-5286 (Print)
IS  - 0008-5286 (Linking)
VI  - 51
IP  - 5
DP  - 2010 May
TI  - An ethicist's commentary on whether veterinarians should condemn activist attacks
      on confinement agriculture?
PG  - 451
FAU - Rollin, Bernard E
AU  - Rollin BE
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Vet J
JT  - The Canadian veterinary journal = La revue veterinaire canadienne
JID - 0004653
SB  - IM
MH  - Animal Husbandry/*ethics/standards
MH  - Animal Rights
MH  - *Animal Welfare
MH  - Animals
MH  - Housing, Animal/ethics/standards
MH  - Humans
MH  - Veterinarians/*ethics
MH  - Veterinary Medicine/*ethics/standards
PMC - PMC2857421
EDAT- 2010/08/03 06:00
MHDA- 2010/10/20 06:00
CRDT- 2010/08/03 06:00
PHST- 2010/08/03 06:00 [entrez]
PHST- 2010/08/03 06:00 [pubmed]
PHST- 2010/10/20 06:00 [medline]
PST - ppublish
SO  - Can Vet J. 2010 May;51(5):451.


PMID- 20675739
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20100906
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 9
DP  - 2010 Sep
TI  - Asperger syndrome and the supposed obligation not to bring disabled lives into
      the world.
PG  - 521-4
LID - 10.1136/jme.2010.036459 [doi]
AB  - Asperger syndrome (AS) is an autistic spectrum condition that shares the range of
      social impairments associated with classic autism widely regarded as disabling,
      while also often giving rise to high levels of ability in areas such as maths,
      science, engineering and music. The nature of this striking duality of disability
      and ability is examined, along with its implications for our thinking about
      disability and the relevance of levels and kinds of disability to reproductive
      choices. In particular, it may be seen as posing a challenge to John Harris's
      influential position in reproductive ethics relating to disability. The paper
      argues that if, as Harris maintains, there is a quite general moral obligation to
      avoid bringing disabled lives into the world regardless of the level of
      disability, then AS must be seen as having a strong claim to be exempt from such 
      an obligation. However, a broader critique of Harris's position leads to the
      conclusion that, in fact, this putative obligation does not exist.
FAU - Walsh, Pat
AU  - Walsh P
AD  - Centre of Medical Law and Ethics, School of Law, King's College London, Strand,
      London, UK. patricia.walsh@kcl.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20100731
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Asperger Syndrome/genetics/*psychology
MH  - Choice Behavior
MH  - Disability Evaluation
MH  - Disabled Persons/*psychology
MH  - Ethics, Medical
MH  - Humans
MH  - *Moral Obligations
MH  - Parents/*psychology
MH  - Reproductive Behavior/ethics/*psychology
EDAT- 2010/08/03 06:00
MHDA- 2011/11/16 06:00
CRDT- 2010/08/03 06:00
PHST- 2010/08/03 06:00 [entrez]
PHST- 2010/08/03 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - jme.2010.036459 [pii]
AID - 10.1136/jme.2010.036459 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Sep;36(9):521-4. doi: 10.1136/jme.2010.036459. Epub 2010 Jul
      31.


PMID- 20675738
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20100906
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 9
DP  - 2010 Sep
TI  - Complex calculations: ethical issues in involving at-risk healthy individuals in 
      dementia research.
PG  - 553-7
LID - 10.1136/jme.2010.036335 [doi]
AB  - In dementia research evidence is mounting that therapeutic strategies that target
      moderate and even mild Alzheimer's disease may be missing the 'therapeutic
      window'. Given that the neuropathology that leads to Alzheimer's disease probably
      begins somewhere between 10 and 15 years before symptoms manifest, many believe
      that the optimal therapeutic strategy would target persons in the earliest phases
      of disease development or even earlier. This would include, for example, persons 
      with prodromal Alzheimer's and even persons who are deemed at risk. Given the
      nature of research involving the central nervous system, it is conceivable that
      some therapeutic investigations may involve an increase over minimal risk. This
      paper examines how, in dementia research, at-risk persons, although healthy,
      bring multiple and intersecting vulnerabilities to the prospect of research
      participation even though they are clinically healthy. Current guidelines for
      research ethics may not provide adequately for the nuances of 'healthy
      individuals' and their possible vulnerabilities. In the context of
      neurodegenerative disease, the fact of being 'at risk' alters the vulnerability
      profile in significant ways. While healthy persons who are at risk of developing 
      dementia may not appear to warrant placement in the research category of
      vulnerable participants (alongside prisoners, pregnant women and children)
      careful regard for the vulnerabilities that arise as a result of the intersecting
      circumstances of being healthy and at risk of an incurable disease are worthy of 
      increased attention and consideration, particularly as the research effort for
      the increasingly prevalent disease of Alzheimer's moves forward.
FAU - Pierce, Robin
AU  - Pierce R
AD  - University of Oxford, Wellcome Centre for Neuroethics, 16-17 St Ebbe's Street,
      Suite 8, Littlegate House, Oxford OX1 1PT, UK. pierce7@post.harvard.edu
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100731
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Dementia/*diagnosis
MH  - Humans
MH  - Informed Consent/*psychology
MH  - Nontherapeutic Human Experimentation/*ethics
MH  - Patient Selection
MH  - Research/*standards
MH  - *Research Subjects
MH  - Risk Assessment
EDAT- 2010/08/03 06:00
MHDA- 2011/11/16 06:00
CRDT- 2010/08/03 06:00
PHST- 2010/08/03 06:00 [entrez]
PHST- 2010/08/03 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - jme.2010.036335 [pii]
AID - 10.1136/jme.2010.036335 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Sep;36(9):553-7. doi: 10.1136/jme.2010.036335. Epub 2010 Jul
      31.


PMID- 20675737
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20100930
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 10
DP  - 2010 Oct
TI  - Eyewitness in Erewhon academic hospital. Part 12: the fall of the house of
      ethics.
PG  - 578-9
LID - 10.1136/jme.2010.038091 [doi]
FAU - de Beaufort, Inez
AU  - de Beaufort I
AD  - Erasmus MC/University Medical Center, Department of Medical Ethics and Philosophy
      of Medicine, PO Box 2040, 3000 CA Rotterdam, The Netherlands.
      i.debeaufort@erasmusmc.nl
FAU - Meulenberg, Frans
AU  - Meulenberg F
LA  - eng
PT  - Journal Article
DEP - 20100731
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Attitude to Health
MH  - *Ethics, Medical
MH  - Humans
MH  - *Interpersonal Relations
MH  - Wit and Humor as Topic
EDAT- 2010/08/03 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/08/03 06:00
PHST- 2010/08/03 06:00 [entrez]
PHST- 2010/08/03 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - jme.2010.038091 [pii]
AID - 10.1136/jme.2010.038091 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Oct;36(10):578-9. doi: 10.1136/jme.2010.038091. Epub 2010 Jul 
      31.


PMID- 20675736
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20211028
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 10
DP  - 2010 Oct
TI  - Ethical issues surrounding do not attempt resuscitation orders: decisions,
      discussions and deleterious effects.
PG  - 593-7
LID - 10.1136/jme.2010.035725 [doi]
AB  - Since their introduction as 'no code' in the 1980s and their later formalization 
      to 'do not resuscitate' orders, such directions to withhold potentially
      life-extending treatments have been accompanied by multiple ethical issues. The
      arguments for when and why to instigate such orders are explored, including a
      consideration of the concept of futility, allocation of healthcare resources, and
      reaching a balance between quality of life and quality of death. The merits and
      perils of discussing such decisions with patients and/or their relatives are
      reviewed and the unintended implications of 'do not attempt resuscitation' orders
      are examined. Finally, the paper explores some alternative methods to approaching
      the resuscitation decision, and calls for empirical evaluation of such methods
      that may reduce the ethical dilemmas physicians currently face.
FAU - Fritz, Zoe
AU  - Fritz Z
AD  - Department of Acute Medicine, Cambridge University NHS Foundation Trust, Box 275,
      Hills Road, Cambridge, CB2 0QQ, UK. zoefritz@gmail.com
FAU - Fuld, Jonathan
AU  - Fuld J
LA  - eng
GR  - PB-PG-0808-17218/DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100731
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Cardiopulmonary Resuscitation
MH  - Communication
MH  - *Decision Making
MH  - *Ethics, Medical
MH  - Family/psychology
MH  - Humans
MH  - Quality of Life
MH  - Resuscitation Orders/*ethics/psychology
EDAT- 2010/08/03 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/08/03 06:00
PHST- 2010/08/03 06:00 [entrez]
PHST- 2010/08/03 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - jme.2010.035725 [pii]
AID - 10.1136/jme.2010.035725 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Oct;36(10):593-7. doi: 10.1136/jme.2010.035725. Epub 2010 Jul 
      31.


PMID- 20675735
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20100906
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 9
DP  - 2010 Sep
TI  - Ethics Committee or Community? Examining the identity of Czech Ethics Committees 
      in the period of transition.
PG  - 548-52
LID - 10.1136/jme.2009.034298 [doi]
AB  - Reflecting on a three year long exploratory research of ethics committees in the 
      Czech Republic authors discuss the current role and identity of research ethics
      committees. The research of Czech ethics committees focused on both
      self-presentation and self-understanding of ECs members, and how other
      stakeholders (representatives of the pharmaceutical industry) view them. The
      exploratory research was based on formal and informal communication with the
      members of the ethics committees. Members of the research team took part at six
      regular voluntary meetings of the ethics committees' members, organised by the
      Forum of Czech Ethics Committees, and at three summer schools of medical ethics. 
      There were realised twenty-five semi-structured interviews as well as six focus
      group sessions and a participant observation of several regular meetings of three
      ethics committees. On the grounds of experience from the interviews a simple
      questionnaire survey was realised among the members of the ethics committees. The
      ethics committees comprise a community of members working voluntarily, without
      claims to remuneration or prestige; the unifying goal is protection of subjects
      of research. The principal working methods are dialogue and agreement. The
      members of the ethics committees thus, among other things, create an informal
      community, which can be to a certain extent seen as a Kantian ethical community
      in a weak sense. The phenomenon of ethics committees can also be described by
      terms of an epistemic community and a community of practice. These concepts,
      which are borrowed from other authors and areas, are used as a way how to think
      of ECs role and identity a bit differently and are meant as a contribution to the
      current international debate on the topic.
FAU - Simek, Jiri
AU  - Simek J
AD  - University of South Bohemia in Ceske Budejovice, Zatecka 5, Prague 1 110 00,
      Czech Republic. jr.simek@volny.cz
FAU - Zamykalova, Lenka
AU  - Zamykalova L
FAU - Mesanyova, Marie
AU  - Mesanyova M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100731
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Czech Republic
MH  - Ethics Committees/organization & administration/*standards
MH  - Health Policy
MH  - Humans
MH  - Research Design/*standards
MH  - Residence Characteristics
EDAT- 2010/08/03 06:00
MHDA- 2011/11/16 06:00
CRDT- 2010/08/03 06:00
PHST- 2010/08/03 06:00 [entrez]
PHST- 2010/08/03 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - jme.2009.034298 [pii]
AID - 10.1136/jme.2009.034298 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Sep;36(9):548-52. doi: 10.1136/jme.2009.034298. Epub 2010 Jul 
      31.


PMID- 20675674
OWN - NLM
STAT- MEDLINE
DCOM- 20110124
LR  - 20220316
IS  - 1532-2092 (Electronic)
IS  - 1099-5129 (Linking)
VI  - 12
IP  - 10
DP  - 2010 Oct
TI  - EHRA Expert Consensus Statement on the management of cardiovascular implantable
      electronic devices in patients nearing end of life or requesting withdrawal of
      therapy.
PG  - 1480-9
LID - 10.1093/europace/euq275 [doi]
AB  - The purpose of this Consensus Statement is to focus on implantable
      cardioverter-defibrillator (ICD) deactivation in patients with irreversible or
      terminal illness. This statement summarizes the opinions of the Task Force
      members, convened by the European Heart Rhythm Association (EHRA) and the Heart
      Rhythm Society (HRS), based on ethical and legal principles, as well as their own
      clinical, scientific, and technical experience. It is directed to all healthcare 
      professionals who treat patients with implanted ICDs, nearing end of life, in
      order to improve the patient dying process. This statement is not intended to
      recommend or promote device deactivation. Rather, the ultimate judgement
      regarding this procedure must be made by the patient (or in special conditions by
      his/her legal representative) after careful communication about the
      deactivation's consequences, respecting his/her autonomy and clarifying that
      he/she has a legal and ethical right to refuse it. Obviously, the physician asked
      to deactivate the ICD and the industry representative asked to assist can
      conscientiously object to and refuse to perform device deactivation.
FAU - Padeletti, Luigi
AU  - Padeletti L
AD  - 1Department of Heart and Vessels, University of Florence, Florence, Italy.
      lpadeletti@interfree.it
FAU - Arnar, David O
AU  - Arnar DO
FAU - Boncinelli, Lorenzo
AU  - Boncinelli L
FAU - Brachman, Johannes
AU  - Brachman J
FAU - Camm, John A
AU  - Camm JA
FAU - Daubert, Jean Claude
AU  - Daubert JC
FAU - Hassam, Sarah K
AU  - Hassam SK
FAU - Deliens, Luc
AU  - Deliens L
FAU - Glikson, Michael
AU  - Glikson M
FAU - Hayes, David
AU  - Hayes D
FAU - Israel, Carsten
AU  - Israel C
FAU - Lampert, Rachel
AU  - Lampert R
FAU - Lobban, Trudie
AU  - Lobban T
FAU - Raatikainen, Pekka
AU  - Raatikainen P
FAU - Siegal, Gil
AU  - Siegal G
FAU - Vardas, Panos
AU  - Vardas P
CN  - Reviewers:
FAU - Kirchhof, Paulus
AU  - Kirchhof P
FAU - Becker, Rudiger
AU  - Becker R
FAU - Cosio, Francisco
AU  - Cosio F
FAU - Loh, Peter
AU  - Loh P
FAU - Cobbe, Stuart
AU  - Cobbe S
FAU - Grace, Andrew
AU  - Grace A
FAU - Morgan, John
AU  - Morgan J
CN  - EuropeanHeart RhythmAssociation
CN  - Heart Rhythm Society
LA  - eng
PT  - Consensus Development Conference
PT  - Journal Article
DEP - 20100730
PL  - England
TA  - Europace
JT  - Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal 
      of the working groups on cardiac pacing, arrhythmias, and cardiac cellular
      electrophysiology of the European Society of Cardiology
JID - 100883649
SB  - IM
EIN - Europace. 2011 Apr;13(4):599. Kassam, Sarah [corrected to Hassam, Sarah K]
MH  - Consensus
MH  - Defibrillators, Implantable/*ethics
MH  - Device Removal/ethics/legislation & jurisprudence
MH  - Humans
MH  - Palliative Care/*ethics/*legislation & jurisprudence
MH  - Patient Rights/ethics/legislation & jurisprudence
MH  - Terminal Care/*ethics/*legislation & jurisprudence
EDAT- 2010/08/03 06:00
MHDA- 2011/01/25 06:00
CRDT- 2010/08/03 06:00
PHST- 2010/08/03 06:00 [entrez]
PHST- 2010/08/03 06:00 [pubmed]
PHST- 2011/01/25 06:00 [medline]
AID - euq275 [pii]
AID - 10.1093/europace/euq275 [doi]
PST - ppublish
SO  - Europace. 2010 Oct;12(10):1480-9. doi: 10.1093/europace/euq275. Epub 2010 Jul 30.


PMID- 20675431
OWN - NLM
STAT- MEDLINE
DCOM- 20101208
LR  - 20190709
IS  - 1943-4723 (Electronic)
IS  - 0002-8177 (Linking)
VI  - 141
IP  - 8
DP  - 2010 Aug
TI  - What is the ethical course of action when a third-party payer denies coverage for
      a treatment I recommend simply because the treatment is not one of the plan's
      "evidence-based best practices"?
PG  - 1025-6
FAU - Lantz, Marilyn S
AU  - Lantz MS
AD  - School of Dentistry, University of Michigan, Ann Arbor, USA.
FAU - Foy, Patrick J
AU  - Foy PJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Am Dent Assoc
JT  - Journal of the American Dental Association (1939)
JID - 7503060
SB  - IM
CIN - J Am Dent Assoc. 2011 Jan;142(1):20-1; author reply 21. PMID: 21193760
CIN - J Am Dent Assoc. 2011 Jan;142(1):21-2; author reply 22-3. PMID: 21193762
MH  - Beneficence
MH  - Codes of Ethics
MH  - Dental Care/economics/*ethics
MH  - Dentist-Patient Relations/ethics
MH  - Dentists/ethics
MH  - *Ethics, Dental
MH  - Evidence-Based Dentistry/*ethics
MH  - Humans
MH  - Insurance Benefits/economics
MH  - Insurance Coverage/*economics
MH  - Insurance, Health, Reimbursement/*economics
MH  - Interprofessional Relations/ethics
MH  - Patient Participation
MH  - Patient-Centered Care/ethics
MH  - Personal Autonomy
EDAT- 2010/08/03 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/03 06:00
PHST- 2010/08/03 06:00 [entrez]
PHST- 2010/08/03 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 141/8/1025 [pii]
AID - 10.14219/jada.archive.2010.0319 [doi]
PST - ppublish
SO  - J Am Dent Assoc. 2010 Aug;141(8):1025-6. doi: 10.14219/jada.archive.2010.0319.


PMID- 20675063
OWN - NLM
STAT- MEDLINE
DCOM- 20110201
LR  - 20220410
IS  - 1879-355X (Electronic)
IS  - 0360-3016 (Linking)
VI  - 79
IP  - 2
DP  - 2011 Feb 1
TI  - Comparison of liver tumor motion with and without abdominal compression using
      cine-magnetic resonance imaging.
PG  - 602-8
LID - 10.1016/j.ijrobp.2010.04.028 [doi]
AB  - PURPOSE: Abdominal compression (AC) can be used to reduce respiratory liver
      motion in patients undergoing liver stereotactic body radiotherapy. The purpose
      of the present study was to measure the changes in three-dimensional liver tumor 
      motion with and without compression using cine-magnetic resonance imaging.
      PATIENTS AND METHODS: A total of 60 patients treated as a part of an
      institutional research ethics board-approved liver stereotactic body radiotherapy
      protocol underwent cine T2-weighted magnetic resonance imaging through the tumor 
      centroid in the coronal and sagittal planes. A total of 240 cine-magnetic
      resonance imaging sequences acquired at one to three images each second for 30-60
      s were evaluated using an in-house-developed template matching tool (based on the
      coefficient correlation) to measure the magnitude of the tumor motion. The
      average tumor edge displacements were used to determine the magnitude of changes 
      in the caudal-cranial (CC) and anteroposterior (AP) directions, with and without 
      AC. RESULTS: The mean tumor motion without AC of 11.7 mm (range, 4.8-23.3) in the
      CC direction was reduced to 9.4 mm (range, 1.6-23.4) with AC. The tumor motion
      was reduced in both directions (CC and AP) in 52% of the patients and in a single
      direction (CC or AP) in 90% of the patients. The mean decrease in tumor motion
      with AC was 2.3 and 0.6 mm in the CC and AP direction, respectively. Increased
      motion occurred in one or more directions in 28% of patients. Clinically
      significant (>3 mm) decreases were observed in 40% and increases in <2% of
      patients in the CC direction. CONCLUSION: AC can significantly reduce
      three-dimensional liver tumor motion in most patients, although the magnitude of 
      the reduction was smaller than previously reported.
CI  - Copyright A(c) 2011 Elsevier Inc. All rights reserved.
FAU - Eccles, Cynthia L
AU  - Eccles CL
AD  - Radiation Medicine Program, Princess Margaret Hospital, University of Toronto
      Faculty of Medicine, Toronto, ON, Canada.
FAU - Patel, Ritesh
AU  - Patel R
FAU - Simeonov, Anna K
AU  - Simeonov AK
FAU - Lockwood, Gina
AU  - Lockwood G
FAU - Haider, Masoom
AU  - Haider M
FAU - Dawson, Laura A
AU  - Dawson LA
LA  - eng
PT  - Clinical Trial, Phase I
PT  - Clinical Trial, Phase II
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100801
PL  - United States
TA  - Int J Radiat Oncol Biol Phys
JT  - International journal of radiation oncology, biology, physics
JID - 7603616
SB  - IM
MH  - *Abdomen
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Constriction
MH  - Female
MH  - Humans
MH  - Liver Neoplasms/*pathology/*surgery
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - *Movement
MH  - Radiosurgery/*methods
MH  - Respiration
EDAT- 2010/08/03 06:00
MHDA- 2011/02/02 06:00
CRDT- 2010/08/03 06:00
PHST- 2010/01/19 00:00 [received]
PHST- 2010/04/18 00:00 [revised]
PHST- 2010/04/20 00:00 [accepted]
PHST- 2010/08/03 06:00 [entrez]
PHST- 2010/08/03 06:00 [pubmed]
PHST- 2011/02/02 06:00 [medline]
AID - S0360-3016(10)00604-8 [pii]
AID - 10.1016/j.ijrobp.2010.04.028 [doi]
PST - ppublish
SO  - Int J Radiat Oncol Biol Phys. 2011 Feb 1;79(2):602-8. doi:
      10.1016/j.ijrobp.2010.04.028. Epub 2010 Aug 1.


PMID- 20674800
OWN - NLM
STAT- MEDLINE
DCOM- 20101110
LR  - 20100802
IS  - 1557-9824 (Electronic)
IS  - 0891-5520 (Linking)
VI  - 24
IP  - 3
DP  - 2010 Sep
TI  - Extensively drug-resistant tuberculosis: epidemiology and management challenges.
PG  - 705-25
LID - 10.1016/j.idc.2010.05.001 [doi]
AB  - Widespread global use of rifampin for 2 decades preceded the emergence of
      clinically significant multidrug-resistant tuberculosis (MDR-TB) in the early
      1990s. The prevalence of MDR-TB has gradually increased such that it accounts for
      approximately 5% of the global case burden of disease (approximately half a
      million cases in 2007). Eclipsing this worrying trend is the widespread emergence
      of extensively drug-resistant TB (XDR-TB). This article reviews the insights
      provided by clinical and molecular epidemiology regarding global trends and
      transmission dynamics of XDR-TB, and the challenges clinicians have to face in
      diagnosing and managing cases of XDR-TB. The ethical and management dilemmas
      posed by recurrent defaulters, XDR-TB treatment failures, and isolation of
      incurable patients are also discussed. Given the past global trends in MDR-TB, if
      aggressive preventive and management strategies are not implemented, XDR-TB has
      the potential to severely cripple global control efforts of TB.
CI  - Copyright 2010 Elsevier Ltd. All rights reserved.
FAU - Dheda, Keertan
AU  - Dheda K
AD  - Lung Infection and Immunity Unit, Division of Pulmonology and Clinical Immunology
      & UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town,
      South Africa. keertan.dheda@uct.ac.za
FAU - Warren, Robin M
AU  - Warren RM
FAU - Zumla, Alimuddin
AU  - Zumla A
FAU - Grobusch, Martin P
AU  - Grobusch MP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Infect Dis Clin North Am
JT  - Infectious disease clinics of North America
JID - 8804508
RN  - 0 (Antitubercular Agents)
SB  - IM
MH  - Antitubercular Agents/*pharmacology/therapeutic use
MH  - Bacterial Typing Techniques
MH  - DNA Fingerprinting
MH  - *Disease Outbreaks
MH  - Extensively Drug-Resistant Tuberculosis/diagnosis/*drug
      therapy/*epidemiology/microbiology
MH  - Genotype
MH  - HIV Infections/complications
MH  - Humans
MH  - Mycobacterium tuberculosis/classification/*drug effects/genetics/*isolation &
      purification
MH  - Treatment Outcome
EDAT- 2010/08/03 06:00
MHDA- 2010/11/11 06:00
CRDT- 2010/08/03 06:00
PHST- 2010/08/03 06:00 [entrez]
PHST- 2010/08/03 06:00 [pubmed]
PHST- 2010/11/11 06:00 [medline]
AID - S0891-5520(10)00043-7 [pii]
AID - 10.1016/j.idc.2010.05.001 [doi]
PST - ppublish
SO  - Infect Dis Clin North Am. 2010 Sep;24(3):705-25. doi: 10.1016/j.idc.2010.05.001.


PMID- 20674597
OWN - NLM
STAT- MEDLINE
DCOM- 20110127
LR  - 20100802
IS  - 1558-4623 (Electronic)
IS  - 0001-2998 (Linking)
VI  - 40
IP  - 5
DP  - 2010 Sep
TI  - The institutional review board.
PG  - 385-92
LID - 10.1053/j.semnuclmed.2010.03.007 [doi]
AB  - Several ethical transgressions involving human subjects in scientific research
      during the last century have led to guidelines for acceptable research conduct
      and oversight. Thoughtful examination of these events yielded ethical documents
      whose principles eventually became codified into federal regulations governing
      research. These regulations specify the composition and function of the
      institutional review board (IRB), as well as the criteria by which the IRB judges
      the acceptability of proposed research. Continuous advances in medicine and
      technology generate the need to test new and potentially viable interventions for
      safety and efficacy. These advances in medical science rely heavily on the
      altruism and sometimes heroism of individuals who put their own well being at
      risk for the benefit of others by participating in clinical research experiments.
      It is therefore necessary for researchers to understand the function of the IRB
      and ethics review committees from which approval is required before research in
      human subjects may begin. Understanding the function of the IRB requires an
      appreciation for the rules by which it is governed, as well as the history and
      circumstances that influenced the creation of those rules. Researchers who
      appreciate the IRB's purpose will be better equipped to navigate the labyrinth of
      research guidelines and regulations.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Hart, Raffaella
AU  - Hart R
AD  - Biomedical Research Alliance of New York, Lake Success, NY 11042, USA.
      rhart@brany.com
FAU - Belotto, Michael
AU  - Belotto M
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - Semin Nucl Med
JT  - Seminars in nuclear medicine
JID - 1264464
SB  - IM
MH  - *Ethics Committees, Research/history/legislation & jurisprudence/organization &
      administration
MH  - Government Regulation
MH  - History, 18th Century
MH  - History, 19th Century
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Human Experimentation/ethics/history/legislation & jurisprudence/standards
MH  - Humans
EDAT- 2010/08/03 06:00
MHDA- 2011/01/29 06:00
CRDT- 2010/08/03 06:00
PHST- 2010/08/03 06:00 [entrez]
PHST- 2010/08/03 06:00 [pubmed]
PHST- 2011/01/29 06:00 [medline]
AID - S0001-2998(10)00030-9 [pii]
AID - 10.1053/j.semnuclmed.2010.03.007 [doi]
PST - ppublish
SO  - Semin Nucl Med. 2010 Sep;40(5):385-92. doi: 10.1053/j.semnuclmed.2010.03.007.


PMID- 20674430
OWN - NLM
STAT- MEDLINE
DCOM- 20110323
LR  - 20220331
IS  - 1578-1291 (Electronic)
IS  - 1130-2399 (Linking)
VI  - 21
IP  - 4
DP  - 2010 Oct-Dec
TI  - [Perception of ethical attitudes of intensive care nurses on treatment
      limitation].
PG  - 142-9
LID - 10.1016/j.enfi.2010.06.001 [doi]
AB  - OBJECTIVE: Analyze the perception of intensive care nurses regarding the
      limitation of therapeutic efforts (LET). METHOD: A 2-month cross-sectional,
      descriptive study carried out among Intensive Care nursing staff of our Hospital.
      An anonymous survey was used to assess the attitudes of intensive care nurses on 
      LET. RESULTS: Fifty-two nurses (86.6%), 57.7% women, with a working experience of
      8.8+/-4.8 years and 17.7%, had some additional training in ethics. The decision
      not to hospitalize a patient whose short term quality of life is very poor
      changes when the patient's opinion is considered (36.5% vs 61.5%, p=0.008), a
      difference that is greater in male nurses without prior training in ethics. A
      total of 23.1% were not aware of the existence of agreed on guidelines on LET in 
      the Service. A total of 17.3% consider that limiting treatment, either by not
      providing it or by withdrawing it, is a form of passive euthanasia, which would
      be an acceptable practice as opposed to euthanasia and 84.6% consider that
      administering a treatment is not the same as withdrawing it. Of those surveyed,
      36.5% felt that the neither the nursing staff should not participate in the
      decision to limit treatment nor the patients (34.6%) nor family (23.1%).
      CONCLUSIONS: Nursing is not aware of the importance it can have, along with the
      family and patient, in decision making in relationship to the limitation of the
      treatment of the critical patient, providing a humanizing and ethical view of the
      care.
CI  - Copyright (c) 2010 Elsevier Espana, S.L. y SEEIUC. All rights reserved.
FAU - Santana Cabrera, L
AU  - Santana Cabrera L
AD  - Servicio de Medicina Intensiva, Hospital Universitario Insular de Gran Canaria,
      Las Palmas de Gran Canaria, Gran Canaria, Espana. lsancabx@gobiernodecanarias.org
FAU - Gil Hernandez, N
AU  - Gil Hernandez N
FAU - Mendez Santana, A
AU  - Mendez Santana A
FAU - Marrero Sosa, I
AU  - Marrero Sosa I
FAU - Alayon Cabrera, S
AU  - Alayon Cabrera S
FAU - Martin Gonzalez, J C
AU  - Martin Gonzalez JC
FAU - Sanchez Palacios, M
AU  - Sanchez Palacios M
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Percepcion de las actitudes eticas de la enfermeria de cuidados intensivos ante
      la limitacion del tratamiento.
DEP - 20100731
PL  - Spain
TA  - Enferm Intensiva
JT  - Enfermeria intensiva
JID - 9517771
MH  - *Attitude of Health Personnel
MH  - Critical Care/*ethics
MH  - Cross-Sectional Studies
MH  - *Ethics, Nursing
MH  - Female
MH  - Humans
MH  - Male
MH  - Refusal to Treat/*ethics
MH  - Surveys and Questionnaires
EDAT- 2010/08/03 06:00
MHDA- 2011/03/24 06:00
CRDT- 2010/08/03 06:00
PHST- 2010/02/02 00:00 [received]
PHST- 2010/05/17 00:00 [accepted]
PHST- 2010/08/03 06:00 [entrez]
PHST- 2010/08/03 06:00 [pubmed]
PHST- 2011/03/24 06:00 [medline]
AID - S1130-2399(10)00060-X [pii]
AID - 10.1016/j.enfi.2010.06.001 [doi]
PST - ppublish
SO  - Enferm Intensiva. 2010 Oct-Dec;21(4):142-9. doi: 10.1016/j.enfi.2010.06.001. Epub
      2010 Jul 31.


PMID- 20673343
OWN - NLM
STAT- MEDLINE
DCOM- 20101108
LR  - 20211020
IS  - 1472-6963 (Electronic)
IS  - 1472-6963 (Linking)
VI  - 10
DP  - 2010 Jul 30
TI  - Ethics review as a component of institutional approval for a multicentre
      continuous quality improvement project: the investigator's perspective.
PG  - 223
LID - 10.1186/1472-6963-10-223 [doi]
AB  - BACKGROUND: For ethical approval of a multicentre study in Canada, investigators 
      must apply separately to individual Research Ethics Boards (REBs). In principle, 
      the protection of human research subjects is of utmost importance. However, in
      practice, the process of multicentre ethics review can be time consuming and
      costly, requiring duplication of effort for researchers and REBs. We used our
      experience with ethical review of The Canadian Perinatal Network (CPN), to gain
      insight into the Canadian system. METHODS: The applications forms of 16 different
      REBs were abstracted for a list of standardized items. The application process
      across sites was compared. Correspondence between the REB and the investigators
      was documented in order to construct a timeline to approval, identify the
      specific issues raised by each board, and describe how they were resolved.
      RESULTS: Each REB had a different application form. Most (n = 9) had a two or
      three step application process. Overall, it took a median of 31 days (range 2-174
      days) to receive an initial response from the REB. Approval took a median of 42
      days (range 4-443 days). Privacy and consent were the two major issues raised.
      Several additional minor or administrative issues were raised which delayed
      approval. CONCLUSIONS: For CPN, the Canadian REB process of ethical review proved
      challenging. REBs acted independently and without unified application forms or
      submission procedures. We call for a critical examination of the ethical, privacy
      and institutional review processes in Canada, to determine the best way to
      undertake multicentre review.
FAU - Ezzat, Hanna
AU  - Ezzat H
AD  - Department of Obstetrics and Gynaecology, University of British Columbia,
      Vancouver, V6 H 3N1, Canada.
FAU - Ross, Sue
AU  - Ross S
FAU - von Dadelszen, Peter
AU  - von Dadelszen P
FAU - Morris, Tara
AU  - Morris T
FAU - Liston, Robert
AU  - Liston R
FAU - Magee, Laura A
AU  - Magee LA
CN  - CPN Collaborative Group
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20100730
PL  - England
TA  - BMC Health Serv Res
JT  - BMC health services research
JID - 101088677
SB  - IM
MH  - Canada
MH  - Ethics Committees/*organization & administration
MH  - Forms and Records Control/*standards
MH  - Hospitals, Public
MH  - Humans
MH  - Total Quality Management/ethics/*organization & administration
PMC - PMC2921081
IR  - Payne B
FIR - Payne, Beth
IR  - Li L
FIR - Li, Larry
IR  - Massey K
FIR - Massey, Kiran
IR  - Allen V
FIR - Allen, Victoria
IR  - Ansermino M
FIR - Ansermino, Mark
IR  - Audibert F
FIR - Audibert, Francois
IR  - Bujold E
FIR - Bujold, Emmanuel
IR  - Crane J
FIR - Crane, Joan
IR  - Demianczuk N
FIR - Demianczuk, Nestor
IR  - Lee S
FIR - Lee, Shoo
IR  - Liston R
FIR - Liston, Robert
IR  - Magee L
FIR - Magee, Laura
IR  - Moutquin JM
FIR - Moutquin, Jean-Marie
IR  - Piedboeuf B
FIR - Piedboeuf, Bruno
IR  - Smith G
FIR - Smith, Graeme
IR  - von Dadelszen P
FIR - von Dadelszen, Peter
IR  - Walker M
FIR - Walker, Mark
IR  - Whittle W
FIR - Whittle, Wendy
IR  - Dansereau J
FIR - Dansereau, Jerome
IR  - Magee L
FIR - Magee, Laura
IR  - Farquharson D
FIR - Farquharson, Duncan
IR  - Wood S
FIR - Wood, Stephen
IR  - Demianczuk N
FIR - Demianczuk, Nestor
IR  - Olatunbosun F
FIR - Olatunbosun, Femi
IR  - Carson G
FIR - Carson, George
IR  - Smith G
FIR - Smith, Graeme
IR  - Burym C
FIR - Burym, Craig
IR  - McDonald S
FIR - McDonald, Sarah
IR  - Natale R
FIR - Natale, Renato
IR  - Whittle W
FIR - Whittle, Wendy
IR  - Barrett J
FIR - Barrett, Jon
IR  - Walker M
FIR - Walker, Mark
IR  - Gagnon R
FIR - Gagnon, Robert
IR  - Audibert F
FIR - Audibert, Francois
IR  - Pasquier JC
FIR - Pasquier, Jean-Charles
IR  - Bujold E
FIR - Bujold, Emmanuel
IR  - Allen V
FIR - Allen, Victoria
IR  - Crane J
FIR - Crane, Joan
EDAT- 2010/08/03 06:00
MHDA- 2010/11/09 06:00
CRDT- 2010/08/03 06:00
PHST- 2010/02/26 00:00 [received]
PHST- 2010/07/30 00:00 [accepted]
PHST- 2010/08/03 06:00 [entrez]
PHST- 2010/08/03 06:00 [pubmed]
PHST- 2010/11/09 06:00 [medline]
AID - 1472-6963-10-223 [pii]
AID - 10.1186/1472-6963-10-223 [doi]
PST - epublish
SO  - BMC Health Serv Res. 2010 Jul 30;10:223. doi: 10.1186/1472-6963-10-223.


PMID- 20673104
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20201209
IS  - 0003-1488 (Print)
IS  - 0003-1488 (Linking)
VI  - 237
IP  - 3
DP  - 2010 Aug 1
TI  - The ethics of influencing clients.
PG  - 263-7
LID - 10.2460/javma.237.3.263 [doi]
FAU - Yeates, James W
AU  - Yeates JW
AD  - Department of Clinical Veterinary Science, and Centre for Ethics in Medicine,
      Faculty of Medical and Veterinary Sciences, University of Bristol, Langford,
      North Somerset, BS40 5DU, England. James.Yeates@bristol.ac.uk
FAU - Main, David C J
AU  - Main DC
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Vet Med Assoc
JT  - Journal of the American Veterinary Medical Association
JID - 7503067
SB  - IM
MH  - Animal Diseases/therapy
MH  - Animal Husbandry/ethics
MH  - Animal Welfare/ethics
MH  - Animals
MH  - Decision Making
MH  - *Ethics, Professional
MH  - Human-Animal Bond
MH  - Professional Role
MH  - Veterinarians/*ethics/*psychology
MH  - Veterinary Medicine/*ethics
EDAT- 2010/08/03 06:00
MHDA- 2010/09/16 06:00
CRDT- 2010/08/03 06:00
PHST- 2010/08/03 06:00 [entrez]
PHST- 2010/08/03 06:00 [pubmed]
PHST- 2010/09/16 06:00 [medline]
AID - 10.2460/javma.237.3.263 [doi]
PST - ppublish
SO  - J Am Vet Med Assoc. 2010 Aug 1;237(3):263-7. doi: 10.2460/javma.237.3.263.


PMID- 20672926
OWN - NLM
STAT- MEDLINE
DCOM- 20100915
LR  - 20220311
IS  - 1092-0684 (Electronic)
IS  - 1092-0684 (Linking)
VI  - 29
IP  - 2
DP  - 2010 Aug
TI  - Criteria for the ethical conduct of psychiatric neurosurgery clinical trials.
PG  - E9
LID - 10.3171/2010.4.FOCUS09327 [doi]
AB  - There is an urgent need for an effective therapy for treatment-refractory mental 
      illness. Trials ongoing globally that explore surgical treatment, such as deep
      brain stimulation, for refractory psychiatric disease have produced some
      promising early results. However, diverse inclusion criteria and variable
      methodological and ethical standards, combined with the sordid past of
      neuromodulation, confound trial interpretation and threaten the integrity of a
      new and emerging science. What is required is a standard of ethical practice,
      globally applied, for neurosurgical trials in psychiatry that protects patients
      and maintains a high ethical benchmark for clinicians and researchers to meet.
      With mental illness, as well as treatment resistance, reaching epidemic
      proportions, ethically and scientifically sound clinical trials will lead to
      effective and safe surgical treatments that will become vital components of the
      clinicians' armamentarium. Ethical criteria, such as the ones proposed here, need
      to be established now and applied in earnest if the field is to move forward and 
      if patients with no other therapeutic options are to receive much-needed
      treatment.
FAU - Lipsman, Nir
AU  - Lipsman N
AD  - Division of Neurosurgery, Toronto Western Hospital, University Health Network,
      University of Toronto, Canada. nir.lipsman@utoronto.ca
FAU - Bernstein, Mark
AU  - Bernstein M
FAU - Lozano, Andres M
AU  - Lozano AM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Neurosurg Focus
JT  - Neurosurgical focus
JID - 100896471
SB  - IM
MH  - Clinical Trials as Topic/*ethics
MH  - Deep Brain Stimulation/ethics/methods
MH  - *Ethics, Research
MH  - Guidelines as Topic/standards
MH  - Humans
MH  - Mental Disorders/surgery/*therapy
MH  - Neurosurgery/*ethics
MH  - Psychiatry/*ethics
MH  - Psychosurgery/ethics/methods
EDAT- 2010/08/03 06:00
MHDA- 2010/09/17 06:00
CRDT- 2010/08/03 06:00
PHST- 2010/08/03 06:00 [entrez]
PHST- 2010/08/03 06:00 [pubmed]
PHST- 2010/09/17 06:00 [medline]
AID - 10.3171/2010.4.FOCUS09327 [doi]
PST - ppublish
SO  - Neurosurg Focus. 2010 Aug;29(2):E9. doi: 10.3171/2010.4.FOCUS09327.


PMID- 20672916
OWN - NLM
STAT- MEDLINE
DCOM- 20100915
LR  - 20100802
IS  - 1092-0684 (Electronic)
IS  - 1092-0684 (Linking)
VI  - 29
IP  - 2
DP  - 2010 Aug
TI  - Deep brain stimulation in the management of disorders of consciousness: a review 
      of physiology, previous reports, and ethical considerations.
PG  - E14
LID - 10.3171/2010.4.FOCUS1096 [doi]
AB  - Patients suffering from disorders of consciousness constitute a population that
      exists largely outside of the daily practice patterns of neurosurgeons.
      Historically, treatment has focused on nursing and custodial issues with limited 
      neurosurgical intervention. Recently, however, deep brain stimulation has been
      explored to restore cognitive and physical function to patients in minimally
      conscious states. In this article, the authors characterize the physiological
      mechanisms for the use of deep brain stimulation in persistently vegetative and
      minimally conscious patients, review published cases and associated ethical
      concerns, and discuss future directions of this technology.
FAU - Sen, Anish N
AU  - Sen AN
AD  - Jefferson Medical College, Thomas Jefferson University, Philadelphia,
      Pennsylvania, USA.
FAU - Campbell, Peter G
AU  - Campbell PG
FAU - Yadla, Sanjay
AU  - Yadla S
FAU - Jallo, Jack
AU  - Jallo J
FAU - Sharan, Ashwini D
AU  - Sharan AD
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Neurosurg Focus
JT  - Neurosurgical focus
JID - 100896471
SB  - IM
MH  - Cerebral Cortex/physiology
MH  - Consciousness Disorders/*therapy
MH  - Deep Brain Stimulation/ethics/*methods
MH  - Humans
MH  - Neural Pathways/physiology
MH  - Persistent Vegetative State/therapy
MH  - Reticular Formation/physiology
MH  - Thalamus/physiology
MH  - Treatment Outcome
RF  - 42
EDAT- 2010/08/03 06:00
MHDA- 2010/09/17 06:00
CRDT- 2010/08/03 06:00
PHST- 2010/08/03 06:00 [entrez]
PHST- 2010/08/03 06:00 [pubmed]
PHST- 2010/09/17 06:00 [medline]
AID - 10.3171/2010.4.FOCUS1096 [doi]
PST - ppublish
SO  - Neurosurg Focus. 2010 Aug;29(2):E14. doi: 10.3171/2010.4.FOCUS1096.


PMID- 20672911
OWN - NLM
STAT- MEDLINE
DCOM- 20100915
LR  - 20181201
IS  - 1092-0684 (Electronic)
IS  - 1092-0684 (Linking)
VI  - 29
IP  - 2
DP  - 2010 Aug
TI  - Deep brain stimulation between 1947 and 1987: the untold story.
PG  - E1
LID - 10.3171/2010.4.FOCUS10106 [doi]
AB  - Deep brain stimulation (DBS) is the most rapidly expanding field in neurosurgery.
      Movement disorders are well-established indications for DBS, and a number of
      other neurological and psychiatric indications are currently being investigated. 
      Numerous contemporary opinions, reviews, and viewpoints on DBS fail to provide a 
      comprehensive account of how this method came into being. Misconceptions in the
      narrative history of DBS conveyed by the wealth of literature published over the 
      last 2 decades can be summarized as follows: Deep brain stimulation was invented 
      in 1987. The utility of high-frequency stimulation was also discovered in 1987.
      Lesional surgery preceded DBS. Deep brain stimulation was first used in the
      treatment of movement disorders and was subsequently used in the treatment of
      psychiatric and behavioral disorders. Reports of nonmotor effects of subthalamic 
      nucleus DBS prompted its use in psychiatric illness. Early surgical interventions
      for psychiatric illness failed to adopt a multidisciplinary approach;
      neurosurgeons often worked "in isolation" from other medical specialists. The
      involvement of neuro-ethicists and multidisciplinary teams are novel standards
      introduced in the modern practice of DBS for mental illness that are essential in
      avoiding the unethical behavior of bygone eras. In this paper, the authors
      examined each of these messages in the light of literature published since 1947
      and formed the following conclusions. Chronic stimulation of subcortical
      structures was first used in the early 1950s, very soon after the introduction of
      human stereotaxy. Studies and debate on the stimulation frequency most likely to 
      achieve desirable results and avoid side effects date back to the early days of
      DBS; several authors advocated the use of "high" frequency, although the exact
      frequency was not always specified. Ablative surgery and electrical stimulation
      developed in parallel, practically since the introduction of human stereotactic
      surgery. The first applications of both ablative surgery and chronic subcortical 
      stimulation were in psychiatry, not in movement disorders. The renaissance of DBS
      in surgical treatment of psychiatric illness in 1999 had little to do with
      nonmotor effects of subthalamic nucleus DBS but involved high-frequency
      stimulation of the very same brain targets previously used in ablative surgery.
      Pioneers in functional neurosurgery mostly worked in multidisciplinary groups,
      including when treating psychiatric illness; those "acting in isolation" were not
      neurosurgeons. Ethical concerns have indeed been addressed in the past, by
      neurosurgeons and others. Some of the questionable behavior in surgery for
      psychiatric illness, including the bygone era of DBS, was at the hands of
      nonneurosurgeons. These practices have been deemed as "dubious and precarious by 
      yesterday's standards."
FAU - Hariz, Marwan I
AU  - Hariz MI
AD  - Unit of Functional Neurosurgery, UCL Institute of Neurology, Queen Square,
      London, UK. m.hariz@ion.ucl.ac.uk
FAU - Blomstedt, Patric
AU  - Blomstedt P
FAU - Zrinzo, Ludvic
AU  - Zrinzo L
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Neurosurg Focus
JT  - Neurosurgical focus
JID - 100896471
SB  - IM
MH  - Brain/surgery
MH  - Deep Brain Stimulation/*history/methods/statistics & numerical data
MH  - History, 20th Century
MH  - Humans
MH  - Mental Disorders/history/surgery
MH  - Movement Disorders/history/therapy
MH  - Neurosurgery/ethics/history
MH  - Psychosurgery/ethics/history
MH  - Stereotaxic Techniques/history
MH  - Subthalamic Nucleus/physiology
RF  - 111
EDAT- 2010/08/03 06:00
MHDA- 2010/09/17 06:00
CRDT- 2010/08/03 06:00
PHST- 2010/08/03 06:00 [entrez]
PHST- 2010/08/03 06:00 [pubmed]
PHST- 2010/09/17 06:00 [medline]
AID - 10.3171/2010.4.FOCUS10106 [doi]
PST - ppublish
SO  - Neurosurg Focus. 2010 Aug;29(2):E1. doi: 10.3171/2010.4.FOCUS10106.


PMID- 20672870
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20100802
IS  - 1445-6354 (Electronic)
IS  - 1445-6354 (Linking)
VI  - 10
IP  - 3
DP  - 2010 Jul-Sep
TI  - Mental health collaborative care: a synopsis of the Rural and Isolated Toolkit.
PG  - 1314
AB  - CONTEXT: For those residing in rural and isolated parts of Canada, obtaining
      quality mental health services is often an unfulfilled wish. Rural and isolated
      communities share the problems of health status and access to care. Health
      deteriorates the greater the distance from urban areas in the following
      dimensions: lower life expectancy than the national average; higher rates of
      disability, violence, poisoning, suicide and accidental death; and more mental
      and physical health issues than those who live in urban areas. The Canadian
      Collaborative Mental Health Initiative (CCMHI) was formed to provide, in part, a 
      practical means to encouraging collaborations between primary care and mental
      health providers. ISSUE: This article provides a synopsis of the Rural and
      Isolated (R&I) toolkit developed through the CCMHI, which was intended to develop
      primary care and mental health collaboration in such areas. This toolkit was
      developed using focus group discussions with mental health providers, and surveys
      completed by providers and consumers. LESSONS LEARNED: Key messages from the
      consultative process included: access to services; interprofessional education;
      consumer involvement; research and evaluation; models of collaboration; ethics;
      funding; and policy and legislation. A flow diagram was devised to detail the
      synthesis and practical application of the toolkit, as well as the challenges,
      key questions and principles of implementation associated with collaborative care
      initiatives in rural and isolated regions.
FAU - Haggarty, John M
AU  - Haggarty JM
AD  - St Joseph's Health Centre, E Thunder Bay, Ontoario, Canada . haggartyj@tbh.net
FAU - Ryan-Nicholls, Kimberley D
AU  - Ryan-Nicholls KD
FAU - Jarva, Janelle A
AU  - Jarva JA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100723
PL  - Australia
TA  - Rural Remote Health
JT  - Rural and remote health
JID - 101174860
SB  - IM
MH  - Canada
MH  - *Cooperative Behavior
MH  - *Health Services Accessibility
MH  - Humans
MH  - *Mental Health Services/economics/ethics
MH  - Program Development
MH  - Public Policy
MH  - *Rural Health Services/economics/ethics
MH  - *Rural Population
EDAT- 2010/08/03 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/08/03 06:00
PHST- 2010/08/03 06:00 [entrez]
PHST- 2010/08/03 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 1314 [pii]
PST - ppublish
SO  - Rural Remote Health. 2010 Jul-Sep;10(3):1314. Epub 2010 Jul 23.


PMID- 22810521
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20120719
IS  - 1080-2371 (Print)
IS  - 1080-2371 (Linking)
VI  - 16
IP  - 4 Behavioral Neurology
DP  - 2010 Aug
TI  - Ethical perspectives in neurology: prescriptions to help healthy patients focus.
PG  - 165-9
LID - 10.1212/01.CON.0000368269.91780.6c [doi]
FAU - Larriviere, Daniel
AU  - Larriviere D
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Continuum (Minneap Minn)
JT  - Continuum (Minneapolis, Minn.)
JID - 9509333
EDAT- 2010/08/01 00:00
MHDA- 2010/08/01 00:01
CRDT- 2012/07/20 06:00
PHST- 2012/07/20 06:00 [entrez]
PHST- 2010/08/01 00:00 [pubmed]
PHST- 2010/08/01 00:01 [medline]
AID - 10.1212/01.CON.0000368269.91780.6c [doi]
AID - 00132979-201008000-00015 [pii]
PST - ppublish
SO  - Continuum (Minneap Minn). 2010 Aug;16(4 Behavioral Neurology):165-9. doi:
      10.1212/01.CON.0000368269.91780.6c.


PMID- 20672390
OWN - NLM
STAT- MEDLINE
DCOM- 20110218
LR  - 20151119
IS  - 1099-0968 (Electronic)
IS  - 1072-4133 (Linking)
VI  - 18
IP  - 6
DP  - 2010 Nov-Dec
TI  - Ethical dilemmas in treating clients with eating disorders: A review and
      application of an integrative ethical decision-making model.
PG  - 434-52
LID - 10.1002/erv.1036 [doi]
AB  - Ethical dilemmas frequently arise in the treatment of clients with eating
      disorders, and clinicians regularly encounter an array of ethical challenges
      related to whether or not overt and covert coercive tactics should be
      implemented. In this paper, the authors provide an overview of perplexing ethical
      questions relevant to medical, nutritional and psychological treatment of clients
      with eating disorders including imposed treatment, enforced feeding, the duty to 
      protect minors and adults, the determination of competence and capacity among
      medically comprised clients, and the effectiveness of coercive treatment for
      clients with eating disorders. The processes of ethical decision-making in terms 
      of ethical principles, professional codes of conduct, the existing empirical
      literature and the use of a decision-making framework are explored. Taking a
      collaborative and client-sensitive approach, the authors outline and apply an
      integrative ethical decision-making model to facilitate clinicians'
      decision-making process.
CI  - Copyright (c) 2010 John Wiley & Sons, Ltd and Eating Disorders Association.
FAU - Matusek, Jill Anne
AU  - Matusek JA
AD  - Department of Psychology, Miami University, OH, USA. jamatuse@mtholyoke.edu
FAU - Wright, Margaret O'Dougherty
AU  - Wright MO
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Eur Eat Disord Rev
JT  - European eating disorders review : the journal of the Eating Disorders
      Association
JID - 9436977
SB  - IM
MH  - Decision Making/*ethics
MH  - Ethics, Medical
MH  - Feeding and Eating Disorders/*therapy
MH  - Humans
MH  - Physician-Patient Relations/*ethics
EDAT- 2010/07/31 06:00
MHDA- 2011/02/22 06:00
CRDT- 2010/07/31 06:00
PHST- 2010/07/31 06:00 [entrez]
PHST- 2010/07/31 06:00 [pubmed]
PHST- 2011/02/22 06:00 [medline]
AID - 10.1002/erv.1036 [doi]
PST - ppublish
SO  - Eur Eat Disord Rev. 2010 Nov-Dec;18(6):434-52. doi: 10.1002/erv.1036.


PMID- 20672287
OWN - NLM
STAT- MEDLINE
DCOM- 20101210
LR  - 20100816
IS  - 1860-7314 (Electronic)
IS  - 1860-6768 (Linking)
VI  - 5
IP  - 8
DP  - 2010 Aug
TI  - Editorial: a call for ethical regulation of genetically created organisms (GCOs) 
      beyond GMOs.
PG  - 791
LID - 10.1002/biot.201000262 [doi]
FAU - Lee, Sang Yup
AU  - Lee SY
LA  - eng
PT  - Editorial
PL  - Germany
TA  - Biotechnol J
JT  - Biotechnology journal
JID - 101265833
SB  - IM
MH  - Animals
MH  - *Bioethics
MH  - Biotechnology/*ethics/legislation & jurisprudence
MH  - Genetic Engineering/*ethics/legislation & jurisprudence
MH  - Humans
MH  - *Organisms, Genetically Modified
EDAT- 2010/07/31 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/07/31 06:00
PHST- 2010/07/31 06:00 [entrez]
PHST- 2010/07/31 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1002/biot.201000262 [doi]
PST - ppublish
SO  - Biotechnol J. 2010 Aug;5(8):791. doi: 10.1002/biot.201000262.


PMID- 20671872
OWN - NLM
STAT- MEDLINE
DCOM- 20101206
LR  - 20211020
IS  - 2385-2070 (Electronic)
IS  - 1723-2007 (Linking)
VI  - 8
IP  - 3
DP  - 2010 Jul
TI  - Umbilical cord blood collection, storage and use: ethical issues.
PG  - 139-48
LID - 10.2450/2010.0152-09 [doi]
FAU - Petrini, Carlo
AU  - Petrini C
AD  - Unita di Bioetica, Presidenza, Istituto Superiore di Sanita, Roma, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - Blood Transfus
JT  - Blood transfusion = Trasfusione del sangue
JID - 101237479
SB  - IM
MH  - Blood Banks/*ethics/methods/organization & administration
MH  - Blood Donors
MH  - Europe
MH  - *Fetal Blood
MH  - Humans
PMC - PMC2906192
OTO - NOTNLM
OT  - Ethics
OT  - biobank
OT  - cord blood
OT  - informed consent
EDAT- 2010/07/31 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/07/31 06:00
PHST- 2009/11/30 00:00 [received]
PHST- 2010/01/12 00:00 [accepted]
PHST- 2010/07/31 06:00 [entrez]
PHST- 2010/07/31 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.2450/2010.0152-09 [doi]
PST - ppublish
SO  - Blood Transfus. 2010 Jul;8(3):139-48. doi: 10.2450/2010.0152-09.


PMID- 20671657
OWN - NLM
STAT- MEDLINE
DCOM- 20101122
LR  - 20100730
IS  - 1827-1839 (Electronic)
IS  - 0392-9590 (Linking)
VI  - 29
IP  - 4
DP  - 2010 Aug
TI  - Ethical and legal aspects on the use of images and photographs in medical
      teaching and publication.
PG  - 376-9
AB  - The aim of the study was to investigate the legal and ethical concerns raised
      from the use of photographs and images in medical publication. A search in the
      pertinent literature was performed. It is of paramount importance that the
      patient's autonomy, privacy and confidentiality is respected. In all cases in
      which photographs and images contain identifiable information patient's consent
      for any potential use of this material is mandatory. Patients should be aware
      that with the evolution of electronic publication, once an image is published,
      there is no efficient control of its future misuse. Physicians and hospitals have
      a duty to use with confidentiality any material kept in the patient's medical
      records. Efforts should be made to anonymised images and photographs used in
      teaching and publication so that such information does not raise ethical and
      legal concerns. The procedures for using photographs and images in medical
      publication and teaching should respect the ethical principles and contain only
      anonymous information to avoid legal consequences. Continuous scrutiny and reform
      is required in order to adapt to the changing social and scientific environment.
FAU - Mavroforou, A
AU  - Mavroforou A
AD  - Department of Medical Ethics and Deontology, Faculty of Medicine, University of
      Thessaly, Larissa, Greece.
FAU - Antoniou, G
AU  - Antoniou G
FAU - Giannoukas, A D
AU  - Giannoukas AD
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Int Angiol
JT  - International angiology : a journal of the International Union of Angiology
JID - 8402693
SB  - IM
MH  - Confidentiality
MH  - Diagnostic Imaging/*ethics
MH  - Education, Medical/*ethics/legislation & jurisprudence
MH  - Humans
MH  - Informed Consent
MH  - *Medical Illustration
MH  - Medical Records
MH  - Personal Autonomy
MH  - Photography/*ethics/legislation & jurisprudence
MH  - Publishing/*ethics/legislation & jurisprudence
EDAT- 2010/07/31 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/07/31 06:00
PHST- 2010/07/31 06:00 [entrez]
PHST- 2010/07/31 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - R34102394 [pii]
PST - ppublish
SO  - Int Angiol. 2010 Aug;29(4):376-9.


PMID- 20671455
OWN - NLM
STAT- MEDLINE
DCOM- 20100921
LR  - 20151119
IS  - 1938-808X (Electronic)
IS  - 1040-2446 (Linking)
VI  - 85
IP  - 8
DP  - 2010 Aug
TI  - Beyond "compliance": the role of institutional culture in promoting research
      integrity.
PG  - 1296-302
LID - 10.1097/ACM.0b013e3181e5f0e5 [doi]
AB  - PURPOSE: To contribute data to conceptual explorations of the role of
      institutional culture in promoting research ethics and integrity. METHOD: The
      authors highlight relevant themes that emerged from a multimodal needs assessment
      conducted under the Johns Hopkins Clinical Translational Science Award regarding 
      ethical issues encountered in the conduct of clinical and translational research.
      Qualitative and quantitative data were collected through a short survey targeting
      research staff, course evaluations from a research ethics and integrity education
      course attended primarily by faculty and fellows, a review of institutional
      policies on research ethics education, and in-depth interviews of key
      administrative officials. RESULTS: Major themes included the relative influence
      of regulatory compliance and relationships between research personnel at
      different levels of the organizational hierarchy on the responsible conduct of
      research. The majority of respondents (85%) expressed comfort with reporting
      suspected breaches in research integrity, but the others did not feel comfortable
      doing so for fear of professional repercussions. Respondents provided insight
      into factors in the research environment they felt were most helpful in fostering
      research integrity, particularly with respect to relationships and power
      differentials between individuals or groups. CONCLUSIONS: Compliance with
      research regulations is only one of a number of important factors in an
      institution's ethical culture of research. Equally important are a clear
      articulation of the ethical reasoning that underlies the regulations, and efforts
      to redress power imbalances by encouraging open communication. Other ways of
      improving relationships among various members of the academic research team
      should be the focus of future investigations.
FAU - Geller, Gail
AU  - Geller G
AD  - Departments of Medicine and Pediatrics, Johns Hopkins University School of
      Medicine, Baltimore, MD, USA. ggeller@jhmi.edu
FAU - Boyce, Alison
AU  - Boyce A
FAU - Ford, Daniel E
AU  - Ford DE
FAU - Sugarman, Jeremy
AU  - Sugarman J
LA  - eng
GR  - UL1 RR 025005/RR/NCRR NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Acad Med
JT  - Academic medicine : journal of the Association of American Medical Colleges
JID - 8904605
SB  - IM
MH  - Academic Medical Centers/*ethics
MH  - Biomedical Research/*ethics
MH  - *Ethics Committees, Research
MH  - Ethics, Medical/*education
MH  - Humans
MH  - Interprofessional Relations/*ethics
MH  - Societies, Medical/*ethics
MH  - Surveys and Questionnaires
MH  - United States
EDAT- 2010/07/31 06:00
MHDA- 2010/09/23 06:00
CRDT- 2010/07/31 06:00
PHST- 2010/07/31 06:00 [entrez]
PHST- 2010/07/31 06:00 [pubmed]
PHST- 2010/09/23 06:00 [medline]
AID - 10.1097/ACM.0b013e3181e5f0e5 [doi]
AID - 00001888-201008000-00013 [pii]
PST - ppublish
SO  - Acad Med. 2010 Aug;85(8):1296-302. doi: 10.1097/ACM.0b013e3181e5f0e5.


PMID- 20671450
OWN - NLM
STAT- MEDLINE
DCOM- 20100921
LR  - 20181201
IS  - 1938-808X (Electronic)
IS  - 1040-2446 (Linking)
VI  - 85
IP  - 8
DP  - 2010 Aug
TI  - Rock stars in academic medicine.
PG  - 1269-75
LID - 10.1097/ACM.0b013e3181e5c0bb [doi]
AB  - PURPOSE: To investigate the prevalence and characteristics of faculty rock stars,
      a subset of academic health center faculty who greatly enhance the reputation
      and/or success of their home institution, oftentimes at the expense of a
      disproportionate share of institutional resources. METHOD: In 2008, the authors
      surveyed the deans of 126 U.S. medical schools accredited by the Liaison
      Committee for Medical Education, using a 13-item instrument consisting of Likert 
      scales, pick lists, and open-ended questions. RESULTS: Sixty-four (51%) surveyed 
      deans responded. Respondents were more representative of public than private
      institutions (P < .001) but were proportionately representative of institutions
      of varying faculty size, U.S. New & World Report research rankings, and
      geographic location. The prevalence of rock stars was 1.42% (range 0.07%-6.42%)
      of full-time faculty. Over 74% (46/62) of deans felt that these talented faculty 
      contributed to institutional prominence. Most deans were usually willing to offer
      greater resources to recruit or retain these faculty stars, and 39/62 (63%)
      believed that these individuals were a good investment. Although 53/64 (82.8%) of
      deans believed that other faculty are often or almost always aware that these
      individuals receive preferential treatment, only 37/64 (57.8%) believed that
      other faculty agree with that treatment. Fifty percent or more of deans
      (depending on the characteristic) selected self-promotion, a strong work ethic,
      opportunism, charisma, and political savvy as characteristics that were more
      common in rock stars. CONCLUSIONS: Deans appreciated both the value and the
      leadership challenges associated with the academic medical center rock star.
FAU - Lucey, Catherine R
AU  - Lucey CR
AD  - College of Medicine, Ohio State University, Columbus, Ohio, USA.
FAU - Sedmak, Daniel
AU  - Sedmak D
FAU - Notestine, Mark
AU  - Notestine M
FAU - Souba, Wiley
AU  - Souba W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Acad Med
JT  - Academic medicine : journal of the Association of American Medical Colleges
JID - 8904605
SB  - IM
MH  - *Academic Medical Centers
MH  - Adult
MH  - Education, Medical/*organization & administration
MH  - Faculty, Medical/*standards
MH  - Humans
MH  - *Leadership
MH  - Program Evaluation
MH  - *Schools, Medical
MH  - Surveys and Questionnaires
MH  - United States
MH  - Workforce
MH  - Young Adult
EDAT- 2010/07/31 06:00
MHDA- 2010/09/23 06:00
CRDT- 2010/07/31 06:00
PHST- 2010/07/31 06:00 [entrez]
PHST- 2010/07/31 06:00 [pubmed]
PHST- 2010/09/23 06:00 [medline]
AID - 10.1097/ACM.0b013e3181e5c0bb [doi]
AID - 00001888-201008000-00008 [pii]
PST - ppublish
SO  - Acad Med. 2010 Aug;85(8):1269-75. doi: 10.1097/ACM.0b013e3181e5c0bb.


PMID- 20671292
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20100930
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 10
DP  - 2010 Oct
TI  - Without 'informed consent'? Ethics and ancient mummy research.
PG  - 608-13
LID - 10.1136/jme.2010.036608 [doi]
AB  - Ethical issues are of foremost importance in modern bio-medical science. Ethical 
      guidelines and socio-cultural public awareness exist for modern samples, whereas 
      for ancient mummy studies both are de facto lacking. This is particularly
      striking considering the fact that examinations are done without informed consent
      or that the investigations are invasive due to technological aspects and that it 
      affects personality traits. The aim of this study is to show the pro and contra
      arguments of ancient mummy research from an ethical point of view with a
      particular focus on the various stakeholders involved in this research. Relevant 
      stakeholders in addition to the examined individual are, for example, a
      particular researcher, and the science community in general, likely descendents
      of the mummy or any future generation. Our broad discussion of the moral dilemma 
      of mummy research should help to extract relevant decision-making criteria for
      any such study in future. We specifically do not make any recommendations about
      how to rate these decision-factors, since this is highly dependent on temporal
      and cultural affiliations of the involved researcher. The sustainability of
      modern mummy research is dependent on ethical orientation, which can only be
      given and eventually settled in an interdisciplinary approach such as the one we 
      attempt to present here.
FAU - Kaufmann, I M
AU  - Kaufmann IM
AD  - University Research Priority Program, University of Zurich, Switzerland.
FAU - Ruhli, F J
AU  - Ruhli FJ
LA  - eng
PT  - Journal Article
DEP - 20100729
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Bioethical Issues
MH  - *Ethics, Research
MH  - Humans
MH  - Informed Consent/*ethics/legislation & jurisprudence
MH  - Morals
MH  - *Mummies
EDAT- 2010/07/31 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/07/31 06:00
PHST- 2010/07/31 06:00 [entrez]
PHST- 2010/07/31 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - jme.2010.036608 [pii]
AID - 10.1136/jme.2010.036608 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Oct;36(10):608-13. doi: 10.1136/jme.2010.036608. Epub 2010 Jul
      29.


PMID- 20670991
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20110720
IS  - 1477-0903 (Electronic)
IS  - 0960-3271 (Linking)
VI  - 30
IP  - 8
DP  - 2011 Aug
TI  - Just who is at risk? The ethics of environmental regulation.
PG  - 795-819
LID - 10.1177/0960327110379252 [doi]
AB  - The willingness to view risk as part of daily life has vanished. A risk-averse
      mindset among environmental regulators engenders confusion between the ethics of 
      intention and the ethics of consequence, leading to the elevation of the
      precautionary principle with unintended and often unfortunate outcomes.
      Environmental risk assessment is conservative, but the actual level of
      conservatism cannot be determined. High-end exposure assumptions and current
      toxicity criteria from the USEPA, based on linear extrapolation for carcinogens
      and default uncertainty factors for systemic toxicants, obscure the degree of
      conservatism in risk assessments. Ideally, one could choose a percentile of the
      target population to include within environmental standards, but this choice is
      complicated by the food, pharmaceutical and advertising industries, whose
      activities, inadvertent or not, often promote maladaptive and unhealthy lifestyle
      choices. There has lately been much discussion about background exposures and
      disease processes and their potential to increase the risk from environmental
      chemicals. Should these background exposures or disease processes, especially
      those associated with maladaptive individual choices, be included as part of a
      regulatory risk evaluation? A significant ethical question is whether
      environmental regulation should protect those pursuing a self-destructive
      lifestyle that may add to or synergize with otherwise innocuous environmental
      exposures. Choosing a target percentile of protection would provide an increased 
      level of transparency and the flexibility to choose a higher or lower percentile 
      if such a choice is warranted. Transparency and flexibility will lead to more
      responsive environmental regulation that balances protection of public health and
      the stewardship of societal resources.
FAU - Simon, Ted
AU  - Simon T
AD  - Ted Simon LLC, Winston, GA 30187, USA. ted@tedsimon-toxicology.com
LA  - eng
PT  - Journal Article
DEP - 20100729
PL  - England
TA  - Hum Exp Toxicol
JT  - Human & experimental toxicology
JID - 9004560
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Disease/etiology
MH  - Dose-Response Relationship, Drug
MH  - Drug Industry/ethics
MH  - Environmental Exposure/*ethics/legislation & jurisprudence/prevention & control
MH  - Environmental Pollutants/*toxicity
MH  - *Ethical Theory
MH  - Food Industry/ethics
MH  - *Government Regulation
MH  - Guidelines as Topic
MH  - Humans
MH  - Risk Assessment/*ethics/legislation & jurisprudence/methods
MH  - Risk Management/ethics/legislation & jurisprudence/methods
MH  - United States
EDAT- 2010/07/31 06:00
MHDA- 2011/12/13 00:00
CRDT- 2010/07/31 06:00
PHST- 2010/07/31 06:00 [entrez]
PHST- 2010/07/31 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 0960327110379252 [pii]
AID - 10.1177/0960327110379252 [doi]
PST - ppublish
SO  - Hum Exp Toxicol. 2011 Aug;30(8):795-819. doi: 10.1177/0960327110379252. Epub 2010
      Jul 29.


PMID- 20670931
OWN - NLM
STAT- MEDLINE
DCOM- 20101103
LR  - 20140218
IS  - 1940-3208 (Electronic)
IS  - 0744-8481 (Linking)
VI  - 59
IP  - 1
DP  - 2010
TI  - General statement of ethical principles and guidelines.
PG  - 61-4
LID - 10.1080/07448481.2011.497050 [doi]
AB  - ACHA recognizes that these guidelines are a work in progress and will change as
      law and professional standards in the field of college health evolve. At this
      time, ACHA expects that all members actively uphold the principles and guidelines
      detailed in this document, as guides for conduct in professional activities and
      situations when breaches in these practices are evident.
LA  - eng
PT  - Guideline
PT  - Journal Article
PL  - United States
TA  - J Am Coll Health
JT  - Journal of American college health : J of ACH
JID - 8214119
SB  - IM
MH  - *Codes of Ethics
MH  - Health Promotion
MH  - Humans
MH  - *Organizational Policy
MH  - *Societies
MH  - Student Health Services/methods
MH  - Students
MH  - United States
MH  - Universities
EDAT- 2010/07/31 06:00
MHDA- 2010/11/04 06:00
CRDT- 2010/07/31 06:00
PHST- 2010/07/31 06:00 [entrez]
PHST- 2010/07/31 06:00 [pubmed]
PHST- 2010/11/04 06:00 [medline]
AID - W827828001553634 [pii]
AID - 10.1080/07448481.2011.497050 [doi]
PST - ppublish
SO  - J Am Coll Health. 2010;59(1):61-4. doi: 10.1080/07448481.2011.497050.


PMID- 20670593
OWN - NLM
STAT- MEDLINE
DCOM- 20101122
LR  - 20220310
IS  - 1944-7930 (Electronic)
IS  - 1539-6509 (Linking)
VI  - 10
IP  - 50
DP  - 2010 Jul
TI  - Prophylactic HPV vaccines: current knowledge of impact on gynecologic
      premalignancies.
PG  - 7-17
AB  - Approaches for cervical cancer prevention are changing. Screening still remains
      the most effective method for cervical cancer prevention. Guidelines are moving
      to an older group of women to be screened less frequently with combinations of
      technologies that include biomarkers and cytology. HPV vaccination is an
      appropriate option for this older group of women as well, should the woman not
      wish to make her decision about vaccination until 21 years of age, the age of
      screening. Parents making decisions about HPV vaccination for their young
      adolescent daughters need to be fully informed that only continued screening
      prevents cervical cancer. HPV vaccination reduces the possibility of their
      daughter having an abnormal Pap test by 10% if the vaccines have not waned by the
      time the young adolescent becomes sexually active. HPV vaccine efficacy must last
      at least 15 years to contribute to the prevention of cervical cancers. At this
      time, protection against cervical intraepithelial neoplasia grade 2/3 (CIN 2/3)
      is 5 years for Gardasil and 8.4 years for Cervarix. The value of the current
      protection HPV vaccines offer will be viewed differently by different women.
      Physicians' ethical duties are to provide full explanation of the risks and
      benefits of adding HPV vaccination to the ongoing screening programs, and to
      support women in their personal choice for cervical cancer prevention.
FAU - Harper, Diane M
AU  - Harper DM
AD  - University of Missouri-Kansas City School of Medicine, 7900 Lee's Summit Road,
      Kansas City, Missouri 64139, USA. diane.m.harper@gmail.com
FAU - Williams, Karen B
AU  - Williams KB
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Discov Med
JT  - Discovery medicine
JID - 101250006
RN  - 0 (Cancer Vaccines)
RN  - 0 (Papillomavirus Vaccines)
SB  - IM
MH  - Cancer Vaccines/*immunology
MH  - Early Detection of Cancer
MH  - Female
MH  - Genital Neoplasms, Female/diagnosis/*immunology/*prevention & control
MH  - Humans
MH  - Papillomavirus Vaccines/adverse effects/*immunology
MH  - Vaccination/adverse effects
EDAT- 2010/07/31 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/07/31 06:00
PHST- 2010/07/31 06:00 [entrez]
PHST- 2010/07/31 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - Discov Med. 2010 Jul;10(50):7-17.


PMID- 20670462
OWN - NLM
STAT- MEDLINE
DCOM- 20110425
LR  - 20181201
IS  - 1741-203X (Electronic)
IS  - 1041-6102 (Linking)
VI  - 23
IP  - 2
DP  - 2011 Mar
TI  - Evaluation of Alzheimer's Australia Vic Memory Lane Cafes.
PG  - 246-55
LID - 10.1017/S1041610210001560 [doi]
AB  - BACKGROUND: This paper describes the evaluation of the Memory Lane Cafe service
      in Victoria, Australia. The Alzheimer's Australia Vic Memory Lane Cafe model aims
      to provide a social and educational service to people living with dementia and
      their carers, family members or friends. Dementia is a serious health issue in
      Australia, with prevalence estimated at 6.5% of people over 65 years of age.
      Living with dementia has significant social and psychological ramifications,
      often negatively affecting quality of life. Social support groups can improve
      quality of life for people living with dementia. METHODS: The evaluation included
      focus groups and surveys of people with dementia and their carers, staff
      consultation, service provider interviews, and researcher observation. The
      Melbourne Health Mental Health Human Research Ethics Committee approved the
      project. Participants included people with dementia (aged 60 to 93 years,
      previously enrolled in the Alzheimer's Australia Vic's six-week Living With
      Memory Loss Program), their carers, friends and/or family members, staff working 
      in the Cafes, and service providers with links to the Cafes. RESULTS: This
      evaluation found that Memory Lane Cafes promote social inclusion, prevent
      isolation, and improve the social and emotional well-being of attendees. However,
      Cafes did not meet the needs of all potential attendees. CONCLUSIONS: The
      evaluation recommended that existing Cafe services be continued and possibilities
      for extending the Cafes be explored. Based on evaluation outcomes, the Department
      of Health Victoria is funding four additional pilot programs in cafe style
      support services.
FAU - Dow, Briony
AU  - Dow B
AD  - National Ageing Research Institute, Melbourne, Victoria, Australia.
      b.dow@nari.unimelb.edu.au
FAU - Haralambous, Betty
AU  - Haralambous B
FAU - Hempton, Courtney
AU  - Hempton C
FAU - Hunt, Susan
AU  - Hunt S
FAU - Calleja, Diane
AU  - Calleja D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100730
PL  - England
TA  - Int Psychogeriatr
JT  - International psychogeriatrics
JID - 9007918
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Caregivers/psychology
MH  - *Community Health Services/organization & administration
MH  - Dementia/psychology/*therapy
MH  - Female
MH  - Focus Groups
MH  - Humans
MH  - Interpersonal Relations
MH  - Male
MH  - Middle Aged
MH  - Peer Group
MH  - Program Evaluation
MH  - Quality of Life/psychology
MH  - Social Support
MH  - Workforce
EDAT- 2010/07/31 06:00
MHDA- 2011/04/26 06:00
CRDT- 2010/07/31 06:00
PHST- 2010/07/31 06:00 [entrez]
PHST- 2010/07/31 06:00 [pubmed]
PHST- 2011/04/26 06:00 [medline]
AID - S1041610210001560 [pii]
AID - 10.1017/S1041610210001560 [doi]
PST - ppublish
SO  - Int Psychogeriatr. 2011 Mar;23(2):246-55. doi: 10.1017/S1041610210001560. Epub
      2010 Jul 30.


PMID- 20670395
OWN - NLM
STAT- MEDLINE
DCOM- 20110118
LR  - 20211020
IS  - 1466-609X (Electronic)
IS  - 1364-8535 (Linking)
VI  - 14
IP  - 4
DP  - 2010
TI  - The dilemma of good clinical practice in the study of compromised standards of
      care.
PG  - 176
LID - 10.1186/cc9073 [doi]
AB  - Four ethical issues loom over the study by Lieberman and colleagues--the absence 
      of informed consent, the study being non-interventional in situations that
      typically call for life-saving interventions, the bias involved in doctors that
      study their own problematic practice and monopoly over intensive care unit
      triage, and ageism. We learn that the Israeli doctors in this study never make
      no-treatment decisions regarding patients in need of mechanical ventilation. They
      are complicit with botched standards of care for these patients, however,
      accepting without much doubt an ethos of scarce resources and poor managerial
      habits. The main two practical lessons to be taken from this study are that, for 
      patients in need of mechanical ventilation, compromised care is better than a
      policy of intubation only when the intensive care unit is available, and that
      vigorous efforts are needed in order to extirpate ageism.
FAU - Barilan, Yechiel M
AU  - Barilan YM
AD  - Department of Medical Education, Sackler Faculty of Medicine, Tel Aviv
      University, Tel Aviv 69978, Israel. YMBarilan@Gmail.com
LA  - eng
PT  - Comment
PT  - Journal Article
DEP - 20100715
PL  - England
TA  - Crit Care
JT  - Critical care (London, England)
JID - 9801902
SB  - IM
CON - Crit Care. 2010;14(2):R48. PMID: 20353552
MH  - Age Factors
MH  - Aged
MH  - Hospital Mortality
MH  - Humans
MH  - Intensive Care Units/*ethics/standards
MH  - Patient Admission/standards
MH  - Practice Guidelines as Topic/standards
MH  - Respiration, Artificial/*ethics/mortality
PMC - PMC2945077
EDAT- 2010/07/31 06:00
MHDA- 2011/01/19 06:00
CRDT- 2010/07/31 06:00
PHST- 2010/07/31 06:00 [entrez]
PHST- 2010/07/31 06:00 [pubmed]
PHST- 2011/01/19 06:00 [medline]
AID - cc9073 [pii]
AID - 10.1186/cc9073 [doi]
PST - ppublish
SO  - Crit Care. 2010;14(4):176. doi: 10.1186/cc9073. Epub 2010 Jul 15.


PMID- 20670265
OWN - NLM
STAT- MEDLINE
DCOM- 20110307
LR  - 20100730
IS  - 1745-7599 (Electronic)
IS  - 1041-2972 (Linking)
VI  - 22
IP  - 8
DP  - 2010 Aug
TI  - Transsexual primary care.
PG  - 403-8
LID - 10.1111/j.1745-7599.2010.00532.x [doi]
AB  - PURPOSE: Transsexual presentations in primary care stress mainstream health care 
      physical resources, institutional organization, and the cultural flexibility of
      providers and interdisciplinary staff. This article describes the ethical
      landscape, examines gender identity culture, and considers gender reassignment
      physiology. Nurse practitioners are challenged to advocate for this population.
      DATA SOURCES: Sources for the discussion derive from published institutional
      guidelines, institutional and civic policies, web-based information in the public
      domain, and professional journal articles. CONCLUSIONS: Advocacy for cultural
      sensitivity, institutional policy change,and professional integrity will
      determine healthcare quality for this population. Advocacy for cultural awareness
      and institutional change has begun in larger institutions and metropolitan areas,
      but is necessary across primary care settings. IMPLICATIONS FOR PRACTICE: Caring 
      for transsexuals requires knowledge of anatomical reassignments, hormonal therapy
      effects, and cultural sensitivities particular to the gender identity community. 
      Healthcare screening and physical exam modifications for these presentations
      require forethought and appropriate adjustments.
FAU - Jenner, Christopher O
AU  - Jenner CO
AD  - 150 Metcalf Road, Winthrop, Maine, USA. chrisjenner66@hotmail.com
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Am Acad Nurse Pract
JT  - Journal of the American Academy of Nurse Practitioners
JID - 8916634
MH  - Clinical Competence
MH  - *Cultural Competency
MH  - Culture
MH  - Ethics, Nursing
MH  - *Gender Identity
MH  - Homosexuality/psychology
MH  - Humans
MH  - Patient Advocacy
MH  - *Primary Health Care
MH  - Quality of Health Care
MH  - Transsexualism/nursing/*psychology/surgery
EDAT- 2010/07/31 06:00
MHDA- 2011/03/08 06:00
CRDT- 2010/07/31 06:00
PHST- 2010/07/31 06:00 [entrez]
PHST- 2010/07/31 06:00 [pubmed]
PHST- 2011/03/08 06:00 [medline]
AID - JAAN532 [pii]
AID - 10.1111/j.1745-7599.2010.00532.x [doi]
PST - ppublish
SO  - J Am Acad Nurse Pract. 2010 Aug;22(8):403-8. doi:
      10.1111/j.1745-7599.2010.00532.x.


PMID- 20669828
OWN - NLM
STAT- MEDLINE
DCOM- 20100917
LR  - 20161125
IS  - 1461-3123 (Print)
IS  - 1461-3123 (Linking)
VI  - 13
IP  - 7
DP  - 2010 Jul-Aug
TI  - Soapsuds: a lighter way of applying ethics to midwifery practice.
PG  - 20-1
FAU - Lang, Amanda
AU  - Lang A
AD  - Musgrove Park Hospital, Taunton.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Pract Midwife
JT  - The practising midwife
JID - 9814758
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Maternal Health Services/*ethics
MH  - Midwifery/*ethics
MH  - *Nurse's Role
MH  - Nurse-Patient Relations/*ethics
MH  - Pregnancy
MH  - Self Efficacy
MH  - United Kingdom
MH  - Women's Health
EDAT- 2010/07/31 06:00
MHDA- 2010/09/21 06:00
CRDT- 2010/07/31 06:00
PHST- 2010/07/31 06:00 [entrez]
PHST- 2010/07/31 06:00 [pubmed]
PHST- 2010/09/21 06:00 [medline]
PST - ppublish
SO  - Pract Midwife. 2010 Jul-Aug;13(7):20-1.


PMID- 20669782
OWN - NLM
STAT- MEDLINE
DCOM- 20100916
LR  - 20100730
IS  - 0093-0334 (Print)
IS  - 0093-0334 (Linking)
VI  - 40
IP  - 4
DP  - 2010 Jul-Aug
TI  - Synthetic biology, analytic ethics.
PG  - 49
FAU - Kaebnick, Gregory E
AU  - Kaebnick GE
AD  - The Hastings Center, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Hastings Cent Rep
JT  - The Hastings Center report
JID - 0410447
SB  - IM
MH  - *Bioethical Issues
MH  - Biotechnology/*ethics
MH  - Genes, Synthetic/*ethics
MH  - Humans
MH  - United States
EDAT- 2010/07/31 06:00
MHDA- 2010/09/18 06:00
CRDT- 2010/07/31 06:00
PHST- 2010/07/31 06:00 [entrez]
PHST- 2010/07/31 06:00 [pubmed]
PHST- 2010/09/18 06:00 [medline]
PST - ppublish
SO  - Hastings Cent Rep. 2010 Jul-Aug;40(4):49.


PMID- 20669778
OWN - NLM
STAT- MEDLINE
DCOM- 20100916
LR  - 20191111
IS  - 0093-0334 (Print)
IS  - 0093-0334 (Linking)
VI  - 40
IP  - 4
DP  - 2010 Jul-Aug
TI  - Middlebrow medical ethics.
PG  - 20-2
FAU - Montello, Martha
AU  - Montello M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Hastings Cent Rep
JT  - The Hastings Center report
JID - 0410447
SB  - IM
MH  - *Bioethics
MH  - *Books
MH  - Decision Making
MH  - Family/*psychology
MH  - Humans
MH  - *Moral Obligations
MH  - *Social Class
EDAT- 2010/07/31 06:00
MHDA- 2010/09/18 06:00
CRDT- 2010/07/31 06:00
PHST- 2010/07/31 06:00 [entrez]
PHST- 2010/07/31 06:00 [pubmed]
PHST- 2010/09/18 06:00 [medline]
AID - 10.1353/hcr.0.0287 [doi]
PST - ppublish
SO  - Hastings Cent Rep. 2010 Jul-Aug;40(4):20-2. doi: 10.1353/hcr.0.0287.


PMID- 20669246
OWN - NLM
STAT- MEDLINE
DCOM- 20110216
LR  - 20181201
IS  - 1099-0798 (Electronic)
IS  - 0735-3936 (Linking)
VI  - 28
IP  - 5
DP  - 2010 Sep-Oct
TI  - Competence to be executed: An ethical analysis post Panetti.
PG  - 690-706
LID - 10.1002/bsl.951 [doi]
AB  - Competence to be executed evaluations in effect can prevent an execution or
      remove the last meaningful impediment to it. Forensic psychiatrists have primary 
      duties to the legal system and truth and honesty, but like all other areas of
      medical consultation also should balance conflicting secondary traditional
      medical ethical duties. Participation in a legally authorized execution so
      violates medical roles, that it is ethically prohibited by the American Medical
      Association and American Psychiatric Association. This prohibition includes
      treatment intended to restore competence to be executed. However, despite the
      primary treatment intent otherwise being appropriate ethically, like relieving
      suffering or fostering prison safety, if competence to be executed almost
      predictably would be a treatment result, at least the risk of this result should 
      be considered ethically as if it were intended. In contrast, competence to be
      executed assessments can be ethical. Diamond's approach of performing honest
      evaluations only for the defense is an ethical option for such assessments.
      However, it is challenging to persuade judges and juries of the objectivity of
      such honest legitimate assessments. Most practitioners therefore likely would
      consider assessing competence to be executed for either side. This ethically
      hazardous position necessitates sensitivity to potentially seriously conflicting 
      duties and roles.
CI  - Copyright (c) 2010 John Wiley & Sons, Ltd.
FAU - Weinstock, Robert
AU  - Weinstock R
AD  - University of California, Los Angeles, 90025, USA. rweinstock@earthlink.net
FAU - Leong, Gregory B
AU  - Leong GB
FAU - Silva, J Arturo
AU  - Silva JA
LA  - eng
PT  - Journal Article
PT  - Legal Case
PL  - United States
TA  - Behav Sci Law
JT  - Behavioral sciences & the law
JID - 8404861
SB  - IM
MH  - *Capital Punishment
MH  - Criminals/psychology
MH  - Forensic Psychiatry/*ethics
MH  - Homicide
MH  - Humans
MH  - Mental Competency/*legislation & jurisprudence
EDAT- 2010/07/30 06:00
MHDA- 2011/02/17 06:00
CRDT- 2010/07/30 06:00
PHST- 2010/07/30 06:00 [entrez]
PHST- 2010/07/30 06:00 [pubmed]
PHST- 2011/02/17 06:00 [medline]
AID - 10.1002/bsl.951 [doi]
PST - ppublish
SO  - Behav Sci Law. 2010 Sep-Oct;28(5):690-706. doi: 10.1002/bsl.951.


PMID- 20669107
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20131121
IS  - 1019-5149 (Print)
IS  - 1019-5149 (Linking)
VI  - 20
IP  - 3
DP  - 2010 Jul
TI  - The addition of metamizole to morphine and paracetamol improves early
      postoperative analgesia and patient satisfaction after lumbar disc surgery.
PG  - 341-7
LID - 10.5137/1019-5149.JTN.3081-10.3 [doi]
AB  - AIM: Combined analgesic regimens produce sufficient analgesia by additive or
      synergistic effects, and reduce the total dose of analgesics and minimise adverse
      effects. We investigated the metamizole, paracetamol and morphine combination
      with respect to postoperative pain treatment in lumbar disc surgery. MATERIAL AND
      METHODS: After Ethics Committee approval and informed consent, 63 patients were
      allocated to three treatment groups; as Group paracetamol: paracetamol (1 g),
      Group paracetamol-metamizole: paracetamol (1 g) and metamizole (1 g), and Group
      placebo: no analgesic. All the patients received intravenous (i.v.) morphine with
      a patient-controlled analgesia device (PCA) as the rescue analgesic. Pain was
      assessed by the numerical pain rating scale (NRS, 0-3). Total morphine
      consumption at 24 hours, patient satisfaction and side effects were investigated.
      RESULTS: NRS of Group paracetamol-metamizole was low at 15th min, 30th min and
      1st hour, and the difference reached statistical significance at 30th min
      (p=0.033). Patient satisfaction at the same measurement times was high in this
      group. Total morphine consumption and side effects were not statistically
      different between the three groups. CONCLUSION: Addition of metamizole to
      paracetamol along with iv morphine PCA offers an advantage over single iv
      morphine PCA and paracetamol, with respect to early postoperative pain treatment 
      and patient satisfaction.
FAU - Uzun, Sennur
AU  - Uzun S
AD  - Hacettepe University, Faculty of Medicine, Department of Anaesthesiology and
      Reanimation, Ankara, Turkey. sennuruzun@superonline.com
FAU - Aycan, Ilker Onguc
AU  - Aycan IO
FAU - Erden, Ismail Aydin
AU  - Erden IA
FAU - Sahin, Altan
AU  - Sahin A
FAU - Aypar, Ulku
AU  - Aypar U
LA  - eng
PT  - Journal Article
PL  - Turkey
TA  - Turk Neurosurg
JT  - Turkish neurosurgery
JID - 9423821
RN  - 0 (Analgesics)
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Placebos)
RN  - 362O9ITL9D (Acetaminophen)
RN  - 554Z48XN5E (Methimazole)
RN  - 76I7G6D29C (Morphine)
RN  - UF599785JZ (Fentanyl)
SB  - IM
CIN - Turk Neurosurg. 2011 Jan;21(1):116-7. PMID: 21294105
MH  - Acetaminophen/*therapeutic use
MH  - Analgesia/methods
MH  - Analgesics/*therapeutic use
MH  - Analgesics, Opioid/therapeutic use
MH  - Dose-Response Relationship, Drug
MH  - Drug Therapy, Combination
MH  - Fentanyl/*therapeutic use
MH  - Humans
MH  - Intervertebral Disc/*surgery
MH  - Lumbosacral Region/*surgery
MH  - Methimazole/*therapeutic use
MH  - Morphine/*therapeutic use
MH  - Pain Measurement
MH  - Pain, Postoperative/*drug therapy
MH  - Patient Satisfaction
MH  - Placebos
MH  - Postoperative Period
MH  - Safety
EDAT- 2010/07/30 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/07/30 06:00
PHST- 2010/07/30 06:00 [entrez]
PHST- 2010/07/30 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - 10.5137/1019-5149.JTN.3081-10.3 [doi]
PST - ppublish
SO  - Turk Neurosurg. 2010 Jul;20(3):341-7. doi: 10.5137/1019-5149.JTN.3081-10.3.


PMID- 20669029
OWN - NLM
STAT- MEDLINE
DCOM- 20110218
LR  - 20211020
IS  - 1432-1076 (Electronic)
IS  - 0340-6199 (Linking)
VI  - 169
IP  - 12
DP  - 2010 Dec
TI  - Frontline ethical issues in pediatric clinical research: ethical and regulatory
      aspects of seven current bottlenecks in pediatric clinical research.
PG  - 1541-8
LID - 10.1007/s00431-010-1268-6 [doi]
AB  - In the course of the past decades, considerable effort has been expended on the
      ethical guidance and legal regulation of pediatric clinical trials in Europe.
      Nonetheless, the conduct of clinical research in the population of minors
      continues to generate myriad ethical and regulatory issues. This paper explores
      seven bottlenecks in the ethical guidance and legal regulation that currently
      govern pediatric clinical research: (1) the integration of research in therapy,
      (2) the education of clinicians, (3) the empowerment of families, (4) the
      harmonization of protocol review, (5) the assessment non-clinical research
      objectives, (6) the control of placebo use, and (7) the provision of fair
      incentives for pediatric research conduct. For all of these issues, a clear view 
      on the way forward is largely lacking, either because these issues have not been 
      discussed in depth to date or because the existing debates have failed to
      generate a generally supported consensus.
FAU - Pinxten, Wim
AU  - Pinxten W
AD  - Centre for Biomedical Ethics and Law, K.U. Leuven, Kapucijnenvoer 35, PO Box
      7001, 3000 Leuven, Belgium. wim.pinxten@med.kuleuven.be
FAU - Nys, Herman
AU  - Nys H
FAU - Dierickx, Kris
AU  - Dierickx K
LA  - eng
PT  - Journal Article
DEP - 20100729
PL  - Germany
TA  - Eur J Pediatr
JT  - European journal of pediatrics
JID - 7603873
RN  - 0 (Placebos)
SB  - IM
MH  - Biomedical Research/*ethics/*legislation & jurisprudence
MH  - Child
MH  - Clinical Protocols/*standards
MH  - Combined Modality Therapy/ethics
MH  - Europe
MH  - Family
MH  - Health Personnel/*education/ethics/legislation & jurisprudence
MH  - Health Workforce/ethics/legislation & jurisprudence
MH  - Humans
MH  - Integrative Medicine/ethics/legislation & jurisprudence
MH  - Minors
MH  - Pediatrics/*ethics/legislation & jurisprudence
MH  - Placebos
MH  - Research Design/legislation & jurisprudence/*standards
EDAT- 2010/07/30 06:00
MHDA- 2011/02/22 06:00
CRDT- 2010/07/30 06:00
PHST- 2010/05/12 00:00 [received]
PHST- 2010/07/17 00:00 [accepted]
PHST- 2010/07/30 06:00 [entrez]
PHST- 2010/07/30 06:00 [pubmed]
PHST- 2011/02/22 06:00 [medline]
AID - 10.1007/s00431-010-1268-6 [doi]
PST - ppublish
SO  - Eur J Pediatr. 2010 Dec;169(12):1541-8. doi: 10.1007/s00431-010-1268-6. Epub 2010
      Jul 29.


PMID- 20668973
OWN - NLM
STAT- MEDLINE
DCOM- 20101004
LR  - 20211020
IS  - 1528-1132 (Electronic)
IS  - 0009-921X (Linking)
VI  - 468
IP  - 10
DP  - 2010 Oct
TI  - Ethical choice in the medical applications of information theory.
PG  - 2672-7
LID - 10.1007/s11999-010-1466-6 [doi]
AB  - BACKGROUND: Alongside advances in medical information technology (IT), there is
      mounting physician and patient dissatisfaction with present-day clinical
      practice. The effect of introducing increasingly complex medical IT on the
      ethical dimension of the clinical physician's primary task (identified as direct 
      patient care) can be scrutinized through analysis of the EMR software platform.
      QUESTIONS/PURPOSES: We therefore (1) identify IT changes burdensome to the
      clinician in performing patient care and which therefore lower quality of care;
      and (2) suggest methods for clinicians to maintain high quality patient care as
      IT demands increase. METHODS: Elemental relationships from information theory and
      physical chemistry are applied to the profit-generating creation and flow of
      medical information between patients, physicians, administrators, suppliers, and 
      insurers. Ethical implications for patient care and the doctor-patient
      relationship are drawn in the light of these relationships. WHERE ARE WE NOW?:
      Little has been accomplished, or even discussed, regarding limiting healthcare IT
      growth. Quality of patient care is expected to suffer unless physicians carefully
      scrutinize, refine and occasionally reject portions of the increasing healthcare 
      IT burden being placed upon them. WHERE DO WE NEED TO GO?: Better medicine,
      simply understood as more effective prevention and treatment of musculoskeletal
      disease, is our professional goal. We need to establish mechanisms whereby we can
      limit, control or even reverse IT changes that hinder this goal. Clinicians must 
      confront the negative impact many healthcare IT changes have on patient care. HOW
      DO WE GET THERE?: Suggestions for maintaining high standards of practice in the
      face of the new IT burden include: (1) Increasing IT time-awareness. Clinicians
      should examine actual time spent in clinical versus computer-based activity and
      implement changes if that ratio is too high. (2) Increasing IT goal awareness.
      (3) Examine the software creating a medical record to see how much of what it
      records is there for financial, as opposed to medical reasons. Is the software
      helping my patient or someone else's bottom line? Is it for talking to colleagues
      about sick people or to insurance companies?
FAU - Haig, Scott V
AU  - Haig SV
AD  - Department of Orthopaedics, New York Presbyterian Hospital, New York, NY 10021,
      USA. scotthaig@gmail.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Orthop Relat Res
JT  - Clinical orthopaedics and related research
JID - 0075674
SB  - IM
MH  - Access to Information/ethics
MH  - Choice Behavior/*ethics
MH  - Efficiency
MH  - Humans
MH  - Information Dissemination/ethics
MH  - *Information Theory
MH  - Medical Informatics/*ethics
MH  - Medical Records Systems, Computerized/ethics
MH  - Orthopedics/*ethics
MH  - *Physician's Role
MH  - Physician-Patient Relations/ethics
MH  - Quality of Health Care/*ethics
PMC - PMC3049638
EDAT- 2010/07/30 06:00
MHDA- 2010/10/05 06:00
CRDT- 2010/07/30 06:00
PHST- 2010/07/30 06:00 [entrez]
PHST- 2010/07/30 06:00 [pubmed]
PHST- 2010/10/05 06:00 [medline]
AID - 10.1007/s11999-010-1466-6 [doi]
PST - ppublish
SO  - Clin Orthop Relat Res. 2010 Oct;468(10):2672-7. doi: 10.1007/s11999-010-1466-6.


PMID- 20668949
OWN - NLM
STAT- MEDLINE
DCOM- 20110128
LR  - 20211020
IS  - 1572-8633 (Electronic)
IS  - 1386-7423 (Linking)
VI  - 13
IP  - 4
DP  - 2010 Nov
TI  - Death by request in The Netherlands: facts, the legal context and effects on
      physicians, patients and families.
PG  - 355-61
LID - 10.1007/s11019-010-9265-0 [doi]
AB  - In this article I intend to describe an issue of the Dutch euthanasia practice
      that is not common knowledge. After some general introductory descriptions, by
      way of formulating a frame of reference, I shall describe the effects of this
      practice on patients, physicians and families, followed by a more philosophical
      reflection on the significance of these effects for the assessment of the
      authenticity of a request and the nature of unbearable suffering, two key
      concepts in the procedure towards euthanasia or physician-assisted suicide. This 
      article does not focus on the arguments for or against euthanasia and the ethical
      justification of physician-assisted dying. These arguments have been described
      extensively in Kimsma and Van Leeuwen (Asking to die. Inside the Dutch debate
      about euthanasia, Kluwer Academic Publishers, Dordrecht, 1998).
FAU - Kimsma, G K
AU  - Kimsma GK
AD  - Vrije Universiteit Medical Center, Amsterdam, De Boelelaan 1105, 1081 HV,
      Amsterdam, The Netherlands. gk.kimsma@vumc.nl
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Med Health Care Philos
JT  - Medicine, health care, and philosophy
JID - 9815900
SB  - IM
MH  - Attitude of Health Personnel
MH  - *Attitude to Death
MH  - Ethical Review/legislation & jurisprudence
MH  - Euthanasia, Active, Voluntary/ethics/*legislation & jurisprudence/psychology
MH  - Humans
MH  - Netherlands
MH  - Physicians/*psychology
MH  - Religion and Medicine
MH  - Suicide, Assisted/ethics/*legislation & jurisprudence/psychology
PMC - PMC2949557
EDAT- 2010/07/30 06:00
MHDA- 2011/02/01 06:00
CRDT- 2010/07/30 06:00
PHST- 2010/07/30 06:00 [entrez]
PHST- 2010/07/30 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
AID - 10.1007/s11019-010-9265-0 [doi]
PST - ppublish
SO  - Med Health Care Philos. 2010 Nov;13(4):355-61. doi: 10.1007/s11019-010-9265-0.


PMID- 20668821
OWN - NLM
STAT- MEDLINE
DCOM- 20110505
LR  - 20100729
IS  - 0034-9887 (Print)
IS  - 0034-9887 (Linking)
VI  - 138
IP  - 5
DP  - 2010 May
TI  - [Ten myths about withdrawal of mechanical ventilation in terminal patients].
PG  - 639-44
LID - /S0034-98872010000500016 [doi]
AB  - The most difficult of treatment limitation decisions, both for physicians and
      families, is the withdrawal of mechanical ventilation (MV). Many fears and
      uncertainties appear in this decision. They are described as ten myths whose
      falseness is argued in this article. The myths are: 1) Withdrawing MV causes the 
      patients death; 2) Withdrawing MV is euthanasia; 3) Withholding and withdrawing
      MV are morally different; 4) MV can be withdrawn only when the patient has asked 
      for it; 5) Chilean law only authorizes to withdraw VM when brain death has
      occurred; 6) Withdrawing MV cannot be done if the patient is not an organ donor; 
      7) Physicians who withdraw MV are in high risk of legal claims; 8) To withdraw MV
      the physician needs an authorization from the hospital ethics committee, lawyer
      or institutional authority; 9) There is only one way to withdraw MV; 10)
      Withdrawing MV produces great suffering to the patients family. Making clear that
      these myths are false facilitates appropriate decisions, therefore preventing
      therapeutic obstinacy and more suffering of terminally ill patients, which favors
      their peaceful death. For the physician this goal should be as rewarding as
      preventing the death of a curable patient.
FAU - Beca, Juan Pablo
AU  - Beca JP
AD  - Centro de Bioetica, Facultad de Medicina, Universidad del Desarrollo-Clinica
      Alemana, Chile. jpbeca@udd.l
FAU - Montes, Jose Miguel
AU  - Montes JM
FAU - Abarca, Juan
AU  - Abarca J
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Diez mitos sobre el retiro de la ventilacion mecanica en enfermos terminales.
DEP - 20100712
PL  - Chile
TA  - Rev Med Chil
JT  - Revista medica de Chile
JID - 0404312
SB  - IM
MH  - Decision Making/*ethics
MH  - Humans
MH  - Terminal Care/*ethics
MH  - Ventilator Weaning/*ethics
MH  - Ventilators, Mechanical
MH  - Withholding Treatment/*ethics
EDAT- 2010/07/30 06:00
MHDA- 2011/05/06 06:00
CRDT- 2010/07/30 06:00
PHST- 2010/07/30 06:00 [entrez]
PHST- 2010/07/30 06:00 [pubmed]
PHST- 2011/05/06 06:00 [medline]
AID - S0034-98872010000500016 [pii]
AID - /S0034-98872010000500016 [doi]
PST - ppublish
SO  - Rev Med Chil. 2010 May;138(5):639-44. doi: /S0034-98872010000500016. Epub 2010
      Jul 12.


PMID- 20668311
OWN - NLM
STAT- MEDLINE
DCOM- 20101029
LR  - 20121115
IS  - 0258-851X (Print)
IS  - 0258-851X (Linking)
VI  - 24
IP  - 4
DP  - 2010 Jul-Aug
TI  - In vivo research using early life stage models.
PG  - 457-62
AB  - Scientists, for a variety of reasons, need to carry out in vivo research. Since
      experiments that require the use of adult animals pose various logistical,
      economical and ethical issues, the use of embryonic and larval forms of some
      organisms are potentially attractive alternatives. Early life stages are
      appealing because, in general, large numbers of individuals can be maintained in 
      relatively simple housing, minimising costs, and their use involves fewer legal
      formalities. With this succinct review, we aim to provide an overview of
      different biological issues that have been successfully explored with the help of
      eggs, embryos and larvae from the frog, zebrafish and chicken.
FAU - Seabra, Rita
AU  - Seabra R
AD  - FRAME, 96-98 North Sherwood Street, Nottingham, NG1 4EE, UK. rita@frame.org.uk
FAU - Bhogal, Nirmala
AU  - Bhogal N
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - In Vivo
JT  - In vivo (Athens, Greece)
JID - 8806809
SB  - IM
MH  - Animals
MH  - Chick Embryo/cytology/physiology
MH  - Chickens/physiology
MH  - Embryo, Nonmammalian/cytology/physiology
MH  - Female
MH  - Health
MH  - Housing, Animal
MH  - Humans
MH  - Larva/cytology/growth & development/physiology
MH  - *Models, Animal
MH  - Models, Biological
MH  - Ovum/cytology/physiology
MH  - Reproduction
MH  - *Research Design
MH  - Retina/cytology/physiology
MH  - Science/methods
MH  - Species Specificity
MH  - Zebrafish/embryology/physiology
EDAT- 2010/07/30 06:00
MHDA- 2010/10/30 06:00
CRDT- 2010/07/30 06:00
PHST- 2010/07/30 06:00 [entrez]
PHST- 2010/07/30 06:00 [pubmed]
PHST- 2010/10/30 06:00 [medline]
AID - 24/4/457 [pii]
PST - ppublish
SO  - In Vivo. 2010 Jul-Aug;24(4):457-62.


PMID- 20667594
OWN - NLM
STAT- MEDLINE
DCOM- 20110118
LR  - 20100906
IS  - 1873-6386 (Electronic)
IS  - 0160-2527 (Linking)
VI  - 33
IP  - 4
DP  - 2010 Sep-Oct
TI  - Mentally disordered criminal offenders in the Swedish criminal system.
PG  - 220-6
LID - 10.1016/j.ijlp.2010.06.003 [doi]
AB  - Historically, the Swedish criminal justice system conformed to other Western
      penal law systems, exempting severely mentally disordered offenders considered to
      be unaccountable. However, in 1965 Sweden enforced a radical penal law abolishing
      exceptions based on unaccountability. Mentally disordered offenders have since
      then been subjected to various forms of sanctions motivated by the offender's
      need for care and aimed at general prevention. Until 2008, a prison sentence was 
      not allowed for offenders found to have committed a crime under the influence of 
      a severe mental disorder, leaving forensic psychiatric care the most common
      sanction in this group. Such offenders are nevertheless held criminally
      responsible, liable for damages, and encumbered with a criminal record. In most
      cases, such offenders must not be discharged without the approval of an
      administrative court. Two essentially modern principles may be discerned behind
      the "Swedish model": first, an attempted abolishment of moral responsibility,
      omitting concepts such as guilt, accountability, atonement, and retribution, and,
      second, the integration of psychiatric care into the societal reaction and
      control systems. The model has been much criticized, and several governmental
      committees have suggested a re-introduction of a system involving the concept of 
      accountability. This review describes the Swedish special criminal justice
      provisions on mentally disordered offenders including the legislative changes in 
      1965 along with current proposals to return to a pre-1965 system, presents
      current Swedish forensic psychiatric practice and research, and discusses some of
      the ethical, political, and metaphysical presumptions that underlie the current
      system.
CI  - Copyright 2010 Elsevier Ltd. All rights reserved.
FAU - Svennerlind, Christer
AU  - Svennerlind C
AD  - Forensic Psychiatry, Institute of Neuroscience and Physiology, The Sahlgrenska
      Academy at the University of Gothenburg, Sweden.
FAU - Nilsson, Thomas
AU  - Nilsson T
FAU - Kerekes, Nora
AU  - Kerekes N
FAU - Andine, Peter
AU  - Andine P
FAU - Lagerkvist, Margareta
AU  - Lagerkvist M
FAU - Forsman, Anders
AU  - Forsman A
FAU - Anckarsater, Henrik
AU  - Anckarsater H
FAU - Malmgren, Helge
AU  - Malmgren H
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100727
PL  - Netherlands
TA  - Int J Law Psychiatry
JT  - International journal of law and psychiatry
JID - 7806862
SB  - IM
MH  - *Criminal Law/history
MH  - Criminals/*psychology
MH  - Forensic Psychiatry
MH  - History, 20th Century
MH  - Humans
MH  - Mental Competency/*legislation & jurisprudence
MH  - *Mental Disorders/therapy
MH  - Prisoners/psychology
MH  - Punishment
MH  - Risk Assessment
MH  - Sweden
EDAT- 2010/07/30 06:00
MHDA- 2011/01/19 06:00
CRDT- 2010/07/30 06:00
PHST- 2010/07/30 06:00 [entrez]
PHST- 2010/07/30 06:00 [pubmed]
PHST- 2011/01/19 06:00 [medline]
AID - S0160-2527(10)00049-X [pii]
AID - 10.1016/j.ijlp.2010.06.003 [doi]
PST - ppublish
SO  - Int J Law Psychiatry. 2010 Sep-Oct;33(4):220-6. doi: 10.1016/j.ijlp.2010.06.003. 
      Epub 2010 Jul 27.


PMID- 20667322
OWN - NLM
STAT- MEDLINE
DCOM- 20100824
LR  - 20100729
IS  - 1552-6259 (Electronic)
IS  - 0003-4975 (Linking)
VI  - 90
IP  - 2
DP  - 2010 Aug
TI  - Surgical treatment for pediatric mediastinal neurogenic tumors.
PG  - 413-8
LID - 10.1016/j.athoracsur.2010.04.086 [doi]
AB  - BACKGROUND: Mediastinal neurogenic tumors are relatively rare in children, and
      controversies persist about the best surgical approach and long-term survival.
      METHODS: With ethics approval we reviewed the case notes of 43 consecutive
      children (22 boys) operated on for mediastinal neurogenic tumor in two different 
      institutions from March 1998 to June 2009. RESULTS: The average age at diagnosis 
      was 3 years (range, 0.6 to 4.7 years). Of the 43 operated tumors, 20 were
      neuroblastomas (47%), 13 were ganglioneuroblastomas (30%), and 10 were
      ganglioneuromas (23%). Only 6 (14%) of these tumors were discovered incidentally;
      the remaining 37 (86%) presented symptomatically: cough (30%), dyspnea (21%),
      wheezing (11.6%), neurologic spinal compression (7%), dancing eyes syndrome (7%),
      and Horner syndrome (7%). Tumor resection was undertaken by open operation in 38 
      cases (88%) and by thoracoscopy in 5 cases (12%). The children operated on by
      means of thoracoscopy had significantly smaller tumors (p = 0.01) and shorter
      duration of thoracic drain (p = 0.011) and hospitalization (p = 0.016) than those
      who were operated on by thoracotomy. There was not any surgical death.
      Postoperative complications occurred in 11 children (25.6%). Tumor recurrence
      occurred in 4 children (9.3%) operated on by open surgery, and there were 2
      deaths of children with neuroblastoma. The overall survival was 95.4% in an
      average follow-up of 3.5 years (range, 0.7 to 4.4 years). CONCLUSIONS: Surgical
      resection of children with mediastinal neurogenic tumors treated at two
      international tertiary hospitals was safe, and the thoracoscopic approach was
      appropriate for small tumors. The long-term survival was higher when compared
      with those reported for other primary neurogenic tumor locations.
CI  - Copyright 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All
      rights reserved.
FAU - Fraga, Jose Carlos
AU  - Fraga JC
AD  - Surgical Unit of the Institute of Child Health and Great Ormond Street Hospital
      for Children, London, United Kingdom. jc.fraga@terra.com.br
FAU - Aydogdu, Bahattin
AU  - Aydogdu B
FAU - Aufieri, Roberto
AU  - Aufieri R
FAU - Silva, Gabriel V M
AU  - Silva GV
FAU - Schopf, Luciano
AU  - Schopf L
FAU - Takamatu, Eliziane
AU  - Takamatu E
FAU - Brunetto, Algemir
AU  - Brunetto A
FAU - Kiely, Edward
AU  - Kiely E
FAU - Pierro, Agostino
AU  - Pierro A
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Ann Thorac Surg
JT  - The Annals of thoracic surgery
JID - 15030100R
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Female
MH  - Ganglioneuroma/*surgery
MH  - Humans
MH  - Infant
MH  - Male
MH  - Mediastinal Neoplasms/*surgery
MH  - Neuroblastoma/*surgery
MH  - Postoperative Complications/epidemiology
EDAT- 2010/07/30 06:00
MHDA- 2010/08/25 06:00
CRDT- 2010/07/30 06:00
PHST- 2009/12/01 00:00 [received]
PHST- 2010/04/19 00:00 [revised]
PHST- 2010/04/23 00:00 [accepted]
PHST- 2010/07/30 06:00 [entrez]
PHST- 2010/07/30 06:00 [pubmed]
PHST- 2010/08/25 06:00 [medline]
AID - S0003-4975(10)00953-7 [pii]
AID - 10.1016/j.athoracsur.2010.04.086 [doi]
PST - ppublish
SO  - Ann Thorac Surg. 2010 Aug;90(2):413-8. doi: 10.1016/j.athoracsur.2010.04.086.


PMID- 20667090
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1752-4458 (Electronic)
IS  - 1752-4458 (Linking)
VI  - 4
DP  - 2010 Jul 28
TI  - Collective trauma in the Vanni- a qualitative inquiry into the mental health of
      the internally displaced due to the civil war in Sri Lanka.
PG  - 22
LID - 10.1186/1752-4458-4-22 [doi]
AB  - BACKGROUND: From January to May, 2009, a population of 300,000 in the Vanni,
      northern Sri Lanka underwent multiple displacements, deaths, injuries,
      deprivation of water, food, medical care and other basic needs caught between the
      shelling and bombings of the state forces and the LTTE which forcefully recruited
      men, women and children to fight on the frontlines and held the rest hostage.
      This study explores the long term psychosocial and mental health consequences of 
      exposure to massive, existential trauma. METHODS: This paper is a qualitative
      inquiry into the psychosocial situation of the Vanni displaced and their
      ethnography using narratives and observations obtained through participant
      observation; in depth interviews; key informant, family and extended family
      interviews; and focus groups using a prescribed, semi structured open ended
      questionnaire. RESULTS: The narratives, drawings, letters and poems as well as
      data from observations, key informant interviews, extended family and focus group
      discussions show considerable impact at the family and community. The family and 
      community relationships, networks, processes and structures are destroyed. There 
      develops collective symptoms of despair, passivity, silence, loss of values and
      ethical mores, amotivation, dependency on external assistance, but also
      resilience and post-traumatic growth. CONCLUSIONS: Considering the severity of
      family and community level adverse effects and implication for resettlement,
      rehabilitation, and development programmes; interventions for healing of
      memories, psychosocial regeneration of the family and community structures and
      processes are essential.
FAU - Somasundaram, Daya
AU  - Somasundaram D
AD  - Department of Psychiatry, University of Jaffna, Sri Lanka. manathu@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20100728
PL  - England
TA  - Int J Ment Health Syst
JT  - International journal of mental health systems
JID - 101294224
PMC - PMC2923106
EDAT- 2010/07/30 06:00
MHDA- 2010/07/30 06:01
CRDT- 2010/07/30 06:00
PHST- 2010/05/22 00:00 [received]
PHST- 2010/07/28 00:00 [accepted]
PHST- 2010/07/30 06:00 [entrez]
PHST- 2010/07/30 06:00 [pubmed]
PHST- 2010/07/30 06:01 [medline]
AID - 1752-4458-4-22 [pii]
AID - 10.1186/1752-4458-4-22 [doi]
PST - epublish
SO  - Int J Ment Health Syst. 2010 Jul 28;4:22. doi: 10.1186/1752-4458-4-22.


PMID- 20666963
OWN - NLM
STAT- MEDLINE
DCOM- 20101104
LR  - 20131121
IS  - 1447-0756 (Electronic)
IS  - 1341-8076 (Linking)
VI  - 36
IP  - 4
DP  - 2010 Aug
TI  - Combination chemotherapy for Hodgkin's lymphoma during pregnancy: favorable
      outcome for mother and child.
PG  - 882-6
LID - 10.1111/j.1447-0756.2010.01249.x [doi]
AB  - The incidence of malignant neoplasms in pregnant women is rising dramatically.
      The management of such cases poses unusual medical and ethical challenges,
      particularly in hematological malignancies, when potentially teratogenic
      chemotherapy is indicated. We report a case of stage IIA nodular sclerosis
      Hodgkin's lymphoma (HL), diagnosed in a 24-year-old woman at 18 weeks of
      gestation. Individualized combination chemotherapy according to
      etoposide-vinblastine-doxorubicin (EVA) regimen was administered, resulting in
      effective local control of the disease and improvement in the patient's general
      condition. At the 36th week of pregnancy, the patient delivered a healthy female 
      infant by elective cesarian section. Four weeks later,
      bleomycin-dacarbazine-doxorubicin-vinblastine (ABVD) chemotherapy was commenced, 
      which provided complete remission after five cycles. Individualized chemotherapy 
      for HL according to EVA regimen during the second and third trimesters of
      pregnancy, with early cesarian delivery, followed by ABVD regimen, provided a
      positive outcome both for the mother and her child. This strategy may be
      considered as an alternative for the treatment of HL in pregnancy, and deserves
      further clinical assessment.
FAU - Sagan, Dariusz
AU  - Sagan D
AD  - Department of Thoracic Surgery, Medical University of Lublin, Lublin, Poland.
      dariusz.sagan@am.lublin.pl
FAU - Semczuk, Andrzej
AU  - Semczuk A
FAU - Lampka, Elzbieta
AU  - Lampka E
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Australia
TA  - J Obstet Gynaecol Res
JT  - The journal of obstetrics and gynaecology research
JID - 9612761
RN  - 11056-06-7 (Bleomycin)
RN  - 5V9KLZ54CY (Vinblastine)
RN  - 6PLQ3CP4P3 (Etoposide)
RN  - 7GR28W0FJI (Dacarbazine)
RN  - 80168379AG (Doxorubicin)
RN  - ABVD protocol
RN  - EVA regimen
SB  - IM
MH  - Adult
MH  - *Antineoplastic Combined Chemotherapy Protocols
MH  - Bleomycin
MH  - Dacarbazine
MH  - Disease-Free Survival
MH  - Doxorubicin
MH  - Etoposide
MH  - Female
MH  - Hodgkin Disease/*drug therapy
MH  - Humans
MH  - Pregnancy
MH  - Pregnancy Complications, Neoplastic/*drug therapy
MH  - Treatment Outcome
MH  - Vinblastine
EDAT- 2010/07/30 06:00
MHDA- 2010/11/05 06:00
CRDT- 2010/07/30 06:00
PHST- 2010/07/30 06:00 [entrez]
PHST- 2010/07/30 06:00 [pubmed]
PHST- 2010/11/05 06:00 [medline]
AID - JOG1249 [pii]
AID - 10.1111/j.1447-0756.2010.01249.x [doi]
PST - ppublish
SO  - J Obstet Gynaecol Res. 2010 Aug;36(4):882-6. doi:
      10.1111/j.1447-0756.2010.01249.x.


PMID- 20666774
OWN - NLM
STAT- MEDLINE
DCOM- 20101105
LR  - 20141120
IS  - 1365-2141 (Electronic)
IS  - 0007-1048 (Linking)
VI  - 151
IP  - 1
DP  - 2010 Oct
TI  - An introduction to induced pluripotent stem cells.
PG  - 16-24
LID - 10.1111/j.1365-2141.2010.08296.x [doi]
AB  - Recent landmark studies show that it is now possible to convert somatic cells,
      such as skin fibroblasts and B lymphocytes, into pluripotent stem cells that
      closely resemble embryonic stem cells. These induced pluripotent stem (iPS) cells
      can be generated without using human embryos or oocytes, thus bypassing some of
      the ethical issues that have limited the use of human embryonic stems (hES)
      cells. Additionally, they can be derived from the patient to be treated, thereby 
      overcoming problems of immunological rejection associated with the use of
      allogeneic hES cell derived progenitors. Whilst these patient-specific iPS cells 
      have great clinical potential, their immediate utility is likely to be in drug
      screening and for understanding the disease process. This review discusses the
      promise of iPS cells as well as the challenges to their use in the clinic.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Hanley, Joanna
AU  - Hanley J
AD  - Department of Haematology, UCL Cancer Institute, London, UK.
FAU - Rastegarlari, Ghasem
AU  - Rastegarlari G
FAU - Nathwani, Amit C
AU  - Nathwani AC
LA  - eng
GR  - Department of Health/United Kingdom
GR  - Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100727
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
SB  - IM
MH  - Animals
MH  - Cell Differentiation
MH  - Cellular Reprogramming
MH  - Drug Evaluation, Preclinical/methods
MH  - Embryo Research/ethics
MH  - Embryonic Stem Cells/cytology
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*cytology/transplantation
MH  - Mice
EDAT- 2010/07/30 06:00
MHDA- 2010/11/06 06:00
CRDT- 2010/07/30 06:00
PHST- 2010/07/30 06:00 [entrez]
PHST- 2010/07/30 06:00 [pubmed]
PHST- 2010/11/06 06:00 [medline]
AID - BJH8296 [pii]
AID - 10.1111/j.1365-2141.2010.08296.x [doi]
PST - ppublish
SO  - Br J Haematol. 2010 Oct;151(1):16-24. doi: 10.1111/j.1365-2141.2010.08296.x. Epub
      2010 Jul 27.


PMID- 20666328
OWN - NLM
STAT- MEDLINE
DCOM- 20100826
LR  - 20161206
IS  - 0035-9351 (Print)
IS  - 0035-9351 (Linking)
VI  - 89
IP  - 5
DP  - 2010 May
TI  - [A combination of dexmedetomidine with ketamine and opioids results in
      significant inhibition of hemodynamic changes associated with laparoscopic
      cholecystectomy and in prolongation of postoperative analgesia].
PG  - 275-81
AB  - THE AIM OF THE STUDY: Recently, alpha2 sympathoadrenergic drugs are used in
      premedication to improve the perioperative course. The aim of our study was to
      compare a premedication with a new alpha2 sympathoadrenergic drug and standard
      premedication. METHODS: After ethic committee approval and written patient
      consent, in a randomised, double-blinded study, combination of dexmedetomidine
      1.0 microg x kg(-1) + ketamine 0.5 mg x kg(-1) + fentanyl 1.0 microg x kg(-1) +
      atropine 0.5 mg (group FNT), dexmedetomidine 1.0 microg x kg(-1) + ketamine 0.5
      mg x kg(-1) + alfentanil 5.0 microg x kg(-1) + atropine 0.5 mg (group ALFNT), or 
      pethidine 1.0 mg x kg(-1) + atropine 0.5 mg (group Dolsin) was administered to a 
      deltoid muscle 15 min. before anaesthesia (GA) in patients elicited for
      laparoscopic cholecystectomy (LCHE). GA was performed in a standard way, ECG,
      NIBP, respiration rate, SpO2, onset of effect, Observers Assessment of Alertness 
      Sedation Score (OAASS) before GA, circulatory reaction to intubation and
      capnoperitoneum, fentanyl consumption during GA, time to the first request for
      post-operative analgesia and postoperative nausea and vomiting were measured. The
      data were processed by Kruskal-Wallis and Fisher tests. P-value < 0.05 was
      considered significant. RESULTS: There were 16 patients in FNT and Dolsin and 15 
      patients in ALFNT with no differences in demography except for younger age in
      ALFNT. The main differences were in hypertension during capnoperitoneum: 0/16 FNT
      and 1/15 ALFNT vs. 11/16 Dolsin, both p < 0.001, per-operative fentanyl
      consumption: FNT 31.5 microg vs. Dolsin 165.0 microg, p < 0.001 and ALFNT 50.0
      microg, p < 0.05 (ALFNT vs. Dolsin, p < 0.01) and request to the first analgesic 
      post surgery: FNT 1.3 h. vs. Dolsin 0.45 h., p < 0.05 vs. ALFNT 0.8 h., p < 0.01.
      There were no differences in side effects except for bradycardia in ALFNT (p <
      0.05). CONCLUSIONS: Dexmedetomidine-ketamine-fentanyl-atropine combination is
      superior to pethidine-atropine combination in suppressing of adverse hemodynamic 
      effects of capnoperitoneum, decreased need for analgesia during GA and prolonged 
      postoperative analgesia.
FAU - Malek, J
AU  - Malek J
AD  - Klinika anesteziologie a resuscitace 3. LF UK a FNKV. malekj@fnkv.cz
FAU - Marecek, F
AU  - Marecek F
FAU - Hess, L
AU  - Hess L
FAU - Kurzova, A
AU  - Kurzova A
FAU - Ocadlik, M
AU  - Ocadlik M
FAU - Votava, M
AU  - Votava M
LA  - cze
PT  - English Abstract
PT  - Journal Article
PT  - Randomized Controlled Trial
TT  - Kombinace dexmedetomidinu s ketaminem a opioidy vyznamne potlacuje hemodynamicke 
      zmeny zpusobene laparoskopickou cholecystektomii a prodluzuje trvaini pooperacni 
      analgezie.
PL  - Czech Republic
TA  - Rozhl Chir
JT  - Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti
JID - 9815441
RN  - 0 (Analgesics, Non-Narcotic)
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Anesthetics, Combined)
RN  - 0 (Anesthetics, Dissociative)
RN  - 0 (Hypnotics and Sedatives)
RN  - 67VB76HONO (Dexmedetomidine)
RN  - 690G0D6V8H (Ketamine)
RN  - 7C0697DR9I (Atropine)
RN  - 9E338QE28F (Meperidine)
RN  - UF599785JZ (Fentanyl)
SB  - IM
MH  - Analgesics, Non-Narcotic
MH  - Analgesics, Opioid/administration & dosage
MH  - Anesthesia Recovery Period
MH  - Anesthetics, Combined/*administration & dosage
MH  - Anesthetics, Dissociative/administration & dosage
MH  - Atropine/administration & dosage
MH  - *Cholecystectomy, Laparoscopic
MH  - Dexmedetomidine/administration & dosage
MH  - Double-Blind Method
MH  - Female
MH  - Fentanyl/administration & dosage
MH  - Hemodynamics/*drug effects
MH  - Humans
MH  - Hypnotics and Sedatives/administration & dosage
MH  - Ketamine/administration & dosage
MH  - Male
MH  - Meperidine/administration & dosage
MH  - Middle Aged
MH  - Pain, Postoperative/*prevention & control
EDAT- 2010/07/30 06:00
MHDA- 2010/08/27 06:00
CRDT- 2010/07/30 06:00
PHST- 2010/07/30 06:00 [entrez]
PHST- 2010/07/30 06:00 [pubmed]
PHST- 2010/08/27 06:00 [medline]
PST - ppublish
SO  - Rozhl Chir. 2010 May;89(5):275-81.


PMID- 20665547
OWN - NLM
STAT- MEDLINE
DCOM- 20111013
LR  - 20220409
IS  - 1520-6777 (Electronic)
IS  - 0733-2467 (Linking)
VI  - 30
IP  - 1
DP  - 2011 Jan
TI  - Inhibitory activity of alpha-tocopherol on apoptosis in the rat bladder wall
      subjected to androgen deprivation.
PG  - 194-8
LID - 10.1002/nau.20857 [doi]
AB  - Alpha-tocopherol (2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-chromon-8-ol) 
      is used in many previous urological studies. Thus to add to this knowledge in
      this study we studied the potential inhibitory activity on oxidative stress and
      process apoptosis on bladder wall in male rats subjected to androgen deprivation.
      A causal relationship between lower testosterone levels and apoptosis, as a
      component of castration-induced muscle atrophy, has been shown. Male Wistar rats 
      (250-300 g) were used in this experiment, divided into four groups: control (sham
      operation; n=10); castration (n=10); castration, with alpha-tocopherol
      supplementation over preceding four weeks (n=10); and castration, with
      alpha-tocopherol supplementation over preceding four weeks and subsequent eight
      weeks (n=10). Activated caspase-3 was detected using a previously described
      technique, with analysis using stereological methodology. Nonparametric methods
      were used to test statistical significance, taking a significance level of
      P<0.005. This study was approved by the ethics committee of the university where 
      the project was developed. The serum testosterone concentrations before
      castration were less than 20 pg/ml. Analysis of 8-isoprostane showed statistical 
      significance (P<0.0003). The volumetric density of caspase-3 showed significant
      differences between the groups. There was no statistical significance regarding
      caspase-3 between sham and alpha-tocopherol plus castration or between the groups
      that received alpha-tocopherol supplementation. The observations showed that
      there was greater apoptosis in the group with castration alone than in the groups
      with alpha-tocopherol supplementation. This finding, together with the induced
      androgen deprivation and higher 8-isoprostane levels, corroborates the hypothesis
      that alpha-tocopherol supplementation has an important protective effect under
      conditions of oxidative stress, thereby avoiding the apoptotic process,
      especially regarding aging.
CI  - Copyright (c) 2010 Wiley-Liss, Inc.
FAU - Ludwig, Luana
AU  - Ludwig L
AD  - Division of Geriatric Urology, Federal University of Sao Paulo, Sao Paulo,
      Brazil.
FAU - Seraphim, Deborah
AU  - Seraphim D
FAU - Lorenzetti, Fabio
AU  - Lorenzetti F
FAU - Bertolla, Ricardo Pimenta
AU  - Bertolla RP
FAU - Ortiz, Valdemar
AU  - Ortiz V
FAU - Dambros, Miriam
AU  - Dambros M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100721
PL  - United States
TA  - Neurourol Urodyn
JT  - Neurourology and urodynamics
JID - 8303326
RN  - 0 (Antioxidants)
RN  - 27415-26-5 (8-epi-prostaglandin F2alpha)
RN  - 3XMK78S47O (Testosterone)
RN  - B7IN85G1HY (Dinoprost)
RN  - EC 3.4.22.- (Caspase 3)
RN  - H4N855PNZ1 (alpha-Tocopherol)
SB  - IM
MH  - Animals
MH  - Antioxidants/*pharmacology
MH  - Apoptosis/*drug effects
MH  - Caspase 3/metabolism
MH  - Dinoprost/analogs & derivatives/blood
MH  - Male
MH  - Orchiectomy
MH  - Oxidative Stress/*drug effects
MH  - Rats
MH  - Rats, Wistar
MH  - Testosterone/blood
MH  - Urinary Bladder/drug effects/*metabolism
MH  - alpha-Tocopherol/*pharmacology
EDAT- 2010/07/29 06:00
MHDA- 2011/10/14 06:00
CRDT- 2010/07/29 06:00
PHST- 2009/08/26 00:00 [received]
PHST- 2009/10/26 00:00 [accepted]
PHST- 2010/07/29 06:00 [entrez]
PHST- 2010/07/29 06:00 [pubmed]
PHST- 2011/10/14 06:00 [medline]
AID - 10.1002/nau.20857 [doi]
PST - ppublish
SO  - Neurourol Urodyn. 2011 Jan;30(1):194-8. doi: 10.1002/nau.20857. Epub 2010 Jul 21.


PMID- 20665055
OWN - NLM
STAT- MEDLINE
DCOM- 20110121
LR  - 20220409
IS  - 1438-8359 (Electronic)
IS  - 0913-8668 (Linking)
VI  - 24
IP  - 5
DP  - 2010 Oct
TI  - Epidural ropivacaine versus ropivacaine plus tramadol in postoperative analgesia 
      in children undergoing major abdominal surgery: a comparison.
PG  - 700-4
LID - 10.1007/s00540-010-0979-1 [doi]
AB  - PURPOSE: In this study, we aimed to compare the effects of ropivacaine alone and 
      ropivacaine plus tramadol administered epidurally for postoperative analgesia in 
      children. METHODS: Following Ethics Committee approval and informed parent
      consent, 44 children aged between 2 and 12 years, with ASA physical status I or
      II, who were undergoing major abdominal surgery were included in the study.
      Following tracheal intubation, patients were placed into lateral decubitus
      position and an epidural catheter (22-24 G) was inserted by using a Tuohy needle.
      Patients were randomly divided into two groups to receive either ropivacaine
      alone (0.2%), 0.7 ml/kg, in group I, or ropivacaine (0.2%) plus tramadol (2
      mg/kg), with total volume 0.7 ml/kg, in group II, epidurally in both groups.
      Hemodynamic variables, pain and sedation scores, duration of analgesia, and side 
      effects were recorded postoperatively. RESULTS: The duration of analgesia was
      significantly longer in group RT than in group R (298.6 +/- 28 and 867.9 +/-
      106.8 min in group I and II, respectively) (P < 0.05). CHEOPS scores were
      significantly lower in group RT at 30 min, 45 min, and 3 h postoperatively than
      in group R (P < 0.05). However, sedation scores were similar between the two
      groups. Twenty-two patients (100%) in group R and 13 patients (59%) in group RT
      needed supplemental analgesia postoperatively. There were no significant
      differences in side effects between the groups. CONCLUSION: In children
      undergoing major abdominal surgery, epidural tramadol, added to epidural
      ropivacaine, provided lower pain scores, longer duration of analgesia, and lower 
      postoperative analgesic requirement.
FAU - Inanoglu, Kerem
AU  - Inanoglu K
AD  - Department of Anesthesiology, School of Medicine, Mustafa Kemal University, MKU
      Arastirma Hastanesi, Serinyol, 31100 Hatay, Turkey. kinanoglu@yahoo.com
FAU - Ozcengiz, Dilek
AU  - Ozcengiz D
FAU - Gunes, Yasemin
AU  - Gunes Y
FAU - Unlugenc, Hakki
AU  - Unlugenc H
FAU - Isik, Geylan
AU  - Isik G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20100728
PL  - Japan
TA  - J Anesth
JT  - Journal of anesthesia
JID - 8905667
RN  - 0 (Amides)
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Anesthetics, Local)
RN  - 39J1LGJ30J (Tramadol)
RN  - 7IO5LYA57N (Ropivacaine)
SB  - IM
MH  - Abdomen/*surgery
MH  - Amides/administration & dosage/*therapeutic use
MH  - Analgesics, Opioid/administration & dosage/*therapeutic use
MH  - *Anesthesia, Epidural
MH  - Anesthesia, General
MH  - Anesthetics, Local/administration & dosage/*therapeutic use
MH  - Blood Gas Analysis
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Hemodynamics/physiology
MH  - Humans
MH  - Male
MH  - Monitoring, Intraoperative
MH  - Pain Measurement/drug effects
MH  - Pain, Postoperative/*drug therapy
MH  - Ropivacaine
MH  - Sample Size
MH  - Tramadol/administration & dosage/*therapeutic use
MH  - Urologic Surgical Procedures
EDAT- 2010/07/29 06:00
MHDA- 2011/01/22 06:00
CRDT- 2010/07/29 06:00
PHST- 2010/03/04 00:00 [received]
PHST- 2010/06/01 00:00 [accepted]
PHST- 2010/07/29 06:00 [entrez]
PHST- 2010/07/29 06:00 [pubmed]
PHST- 2011/01/22 06:00 [medline]
AID - 10.1007/s00540-010-0979-1 [doi]
PST - ppublish
SO  - J Anesth. 2010 Oct;24(5):700-4. doi: 10.1007/s00540-010-0979-1. Epub 2010 Jul 28.


PMID- 20664513
OWN - NLM
STAT- MEDLINE
DCOM- 20101112
LR  - 20171221
IS  - 1526-2359 (Electronic)
IS  - 1073-2748 (Linking)
VI  - 17
IP  - 3
DP  - 2010 Jul
TI  - Fertility and reproductive considerations in premenopausal patients with breast
      cancer.
PG  - 162-72
AB  - BACKGROUND: Approximately 10% of all new breast cancer diagnoses occur in young
      women. Although lacking medical comorbidities, these patients often have unique
      issues with regard to their reproductive health that merit special consideration.
      As breast cancer outcomes continue to improve, quality of life for patients and
      their families after breast cancer treatment has come to the forefront of cancer 
      research, particularly in the growing field of oncofertility. METHODS: This
      article reviews the literature on the singular situations and controversies faced
      by premenopausal breast cancer patients. RESULTS: Data on amenorrhea and the
      effects of modern chemotherapeutic agents on amenorrhea are limited, although the
      role of tamoxifen in amenorrhea is more clearly defined as increasing the rate of
      amenorrhea across several studies. At the forefront of studies on fertility and
      premenopausal breast cancer patients are investigations on fertility preservation
      via ovarian protection and on assisted reproductive technologies. The use of
      gonadotropin-releasing hormone analogs for ovarian protection remains
      controversial and continues to be investigated. CONCLUSIONS: Early integration of
      assessment and counseling regarding fertility preservation is part of the
      multidisciplinary approach in the care of the premenopausal breast cancer patient
      and is key to optimizing both cancer treatment and fertility plans for the
      future. Because of the many ongoing biological, practical, and ethical
      controversies surrounding oncofertility, eligible patients should be strongly
      encouraged to participate in clinical trials and studies to further increase our 
      knowledge in this growing field.
FAU - Lee, M Catherine
AU  - Lee MC
AD  - H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida 33612, USA.
      Marie.Lee@moffitt.org
FAU - Gray, Jhanelle
AU  - Gray J
FAU - Han, Hyo Sook
AU  - Han HS
FAU - Plosker, Shayne
AU  - Plosker S
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Cancer Control
JT  - Cancer control : journal of the Moffitt Cancer Center
JID - 9438457
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Antineoplastic Agents/*adverse effects
MH  - Breast Neoplasms/*drug therapy
MH  - Female
MH  - Fertility/*drug effects
MH  - Humans
MH  - Infertility, Female/chemically induced/*prevention & control
MH  - *Premenopause
EDAT- 2010/07/29 06:00
MHDA- 2010/11/13 06:00
CRDT- 2010/07/29 06:00
PHST- 2010/07/29 06:00 [entrez]
PHST- 2010/07/29 06:00 [pubmed]
PHST- 2010/11/13 06:00 [medline]
AID - 10.1177/107327481001700304 [doi]
PST - ppublish
SO  - Cancer Control. 2010 Jul;17(3):162-72. doi: 10.1177/107327481001700304.


PMID- 20664467
OWN - NLM
STAT- MEDLINE
DCOM- 20101122
LR  - 20220317
IS  - 1542-538X (Electronic)
IS  - 0744-6020 (Linking)
VI  - 29
IP  - 4
DP  - 2010 Jul-Aug
TI  - Informed consent: revisiting the issues.
PG  - 276-80
LID - 10.1097/NOR.0b013e3181e517f1 [doi]
AB  - Informed consent has been widely discussed in the ethics, legal, research, and
      clinical literature. Authors have addressed the ethical and legal bases for
      informed consent, its components, and its implementation both in research and in 
      healthcare delivery. However, although there is considerable literature on the
      subject and the inclusion of this content within the curricula of the various
      schools of the health sciences, questions continue to arise regarding the process
      of informed consent and whether the person's right to self-determine was actually
      upheld. This article revisits issues of informed consent as related to research
      with human subjects and briefly defines informed consent, addresses selected
      issues, and offers some potential strategies to improve the process of obtaining 
      informed consent when conducting research with human subjects.
FAU - Erlen, Judith A
AU  - Erlen JA
AD  - Department of Health and Community Systems, School of Nursing, University of
      Pittsburgh, Pittsburgh, PA, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Orthop Nurs
JT  - Orthopedic nursing
JID - 8409486
MH  - Clinical Trials as Topic
MH  - Disclosure
MH  - Humans
MH  - *Informed Consent
MH  - Self Efficacy
EDAT- 2010/07/29 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/07/29 06:00
PHST- 2010/07/29 06:00 [entrez]
PHST- 2010/07/29 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1097/NOR.0b013e3181e517f1 [doi]
AID - 00006416-201007000-00012 [pii]
PST - ppublish
SO  - Orthop Nurs. 2010 Jul-Aug;29(4):276-80. doi: 10.1097/NOR.0b013e3181e517f1.


PMID- 20663972
OWN - NLM
STAT- MEDLINE
DCOM- 20100930
LR  - 20151119
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 256
IP  - 3
DP  - 2010 Sep
TI  - Rheumatoid arthritis of the hand: monitoring with a simplified MR imaging scoring
      method--preliminary assessment.
PG  - 863-9
LID - 10.1148/radiol.10091759 [doi]
AB  - PURPOSE: To assess a simplified scoring method (Simplified Rheumatoid Arthritis
      Magnetic Resonance Imaging Score [SAMIS]) developed to shorten interpretation
      time, while retaining both correlation with Rheumatoid Arthritis Magnetic
      Resonance Imaging Score (RAMRIS) and same or better intra- and interreader
      reliability. MATERIALS AND METHODS: Ethics board approval and written patient
      consent were obtained. The study was HIPAA compliant. Thirty-eight patients with 
      rheumatoid arthritis and 20 patients with no or early unclassified arthritis
      underwent magnetic resonance imaging of both wrists and hands. RAMRIS was used to
      evaluate erosions (scale, 0-10), edema (scale, 0-3), and synovitis (scale, 0-3). 
      SAMIS assessed only one hand and was based on the radiographic Simple Erosion
      Narrowing Score, thus reducing the number of study areas from 116 to 36. Erosions
      were scored with a scale from 1 to 10. Edema and synovitis were, respectively,
      scored with scales from 0 to 1 and 0 to 2. SAMIS correlation with RAMRIS was
      tested by using the Spearman test. Last, the intra- and interobserver
      reproducibility of both scores were calculated. RESULTS: SAMIS was closely
      correlated with RAMRIS for the entire series (r = 0.91, 0.79, and 0.94,
      respectively, for erosion, edema, and synovitis), as well as in patients with
      rheumatoid arthritis (r = 0.93, 0.81, and 0.92) and those with no or unclassified
      arthritis (r = 0.83, 0.73, and 0.94). The time needed to assess examination
      results with RAMRIS ranged from 5 to 20 minutes (13 minutes +/- 3.90 [standard
      deviation]), whereas it ranged from 2 to 7 minutes (5 minutes +/- 1.45) with
      SAMIS. For each of the three features (erosion, edema, and synovitis),
      intraobserver agreement (RAMRIS: kappa = 0.67, 0.94, 0.81, respectively; SAMIS:
      kappa = 0.66, 1.0, 0.91) and interobserver agreement (RAMRIS: kappa = 0.61, 0.58,
      0.74, respectively; SAMIS: kappa = 0.59, 0.81, 0.81) were good to excellent.
      CONCLUSION: This simplified reproducible scoring scheme could be used to monitor 
      joint damage in rheumatoid arthritis. (c) RSNA, 2010.
FAU - Cyteval, Catherine
AU  - Cyteval C
AD  - Department of Medical Imaging and Rheumatology, Hopital Lapeyronie, Montpellier
      Cedex 5, France. c-cyteval@chu-montpellier.fr
FAU - Miquel, Anne
AU  - Miquel A
FAU - Hoa, Denis
AU  - Hoa D
FAU - Daures, Jean Pierre
AU  - Daures JP
FAU - Mariette, Xavier
AU  - Mariette X
FAU - Combe, Bernard
AU  - Combe B
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20100727
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Arthritis, Rheumatoid/*pathology
MH  - Contrast Media
MH  - Disease Progression
MH  - Female
MH  - Gadolinium DTPA
MH  - Hand/*pathology
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Reproducibility of Results
MH  - Statistics, Nonparametric
EDAT- 2010/07/29 06:00
MHDA- 2010/10/01 06:00
CRDT- 2010/07/29 06:00
PHST- 2010/07/29 06:00 [entrez]
PHST- 2010/07/29 06:00 [pubmed]
PHST- 2010/10/01 06:00 [medline]
AID - radiol.10091759 [pii]
AID - 10.1148/radiol.10091759 [doi]
PST - ppublish
SO  - Radiology. 2010 Sep;256(3):863-9. doi: 10.1148/radiol.10091759. Epub 2010 Jul 27.


PMID- 20663970
OWN - NLM
STAT- MEDLINE
DCOM- 20100930
LR  - 20171116
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 256
IP  - 3
DP  - 2010 Sep
TI  - Effect of different classes of gadolinium-based contrast agents on control and
      nephrogenic systemic fibrosis-derived fibroblast proliferation.
PG  - 735-43
LID - 10.1148/radiol.10091131 [doi]
AB  - PURPOSE: To determine the ability of different types of gadolinium-based contrast
      agents (GBCAs) to stimulate fibroblast proliferation in monolayer cell culture.
      MATERIALS AND METHODS: The National Health Service West Glasgow Ethics Committee 
      granted approval for this study. Fibroblasts established from healthy volunteers 
      (control subjects) and from lesional skin of patients with nephrogenic systemic
      fibrosis were exposed to a range of concentrations of ionic and nonionic linear
      and macrocyclic contrast agents over 4 days, and the effect on growth was
      determined. The lowest concentration of contrast agent that stimulated the
      maximum effect on fibroblast growth was selected for determination of its effect 
      on fibroblast growth over 8 days. The effect of contrast agents on hyaluronan and
      collagen synthesis was determined with an enzyme-linked immunosorbent assay.
      Responses were assessed with analysis of variance (general linear model).
      RESULTS: The linear gadolinium contrast agents (gadodiamide, gadoversetamide,
      gadopentetate dimeglumine, and gadobenate dimeglumine) produced a maximum
      stimulation of fibroblast proliferation at a concentration of 0.1 mmol/L, with
      cell numbers increasing up to 2.3-fold. The macrocyclic contrast agents
      (gadoteric acid and gadoteridol) produced a maximum stimulation of fibroblast
      proliferation at a concentration of 5 mmol/L. The reference gadolinium agents
      (N-methylglucamine gadolinium ethylenediaminetetraacetic acid and gadolinium
      trichloride) stimulated fibroblast proliferation at a concentration of 0.01
      mmol/L and were toxic at a concentration greater than 1 mmol/L. Growth curves
      supported the dose-response observations. Hyaluronan synthesis was stimulated by 
      gadoversetamide, gadobenate dimeglumine, gadodiamide, and gadopentetate
      dimeglumine at a concentration of 0.1 mmol/L and by gadolinium trichloride at a
      concentration of 0.01 mmol/L, whereas collagen synthesis was unaffected.
      CONCLUSION: This study provides evidence that different classes of gadolinium
      chelates stimulate human fibroblast proliferation.
CI  - (c) RSNA, 2010.
FAU - Edward, Michael
AU  - Edward M
AD  - Section of Dermatology, Division of Cancer Sciences, and Glasgow Cardiovascular
      Centre, Faculty of Medicine, University of Glasgow, Glasgow G12 8QQ, Scotland.
      m.edward@clinmed.gla.ac.uk
FAU - Quinn, Jean A
AU  - Quinn JA
FAU - Burden, A David
AU  - Burden AD
FAU - Newton, Ben B
AU  - Newton BB
FAU - Jardine, Alan G
AU  - Jardine AG
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100727
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - 0 (Heterocyclic Compounds)
RN  - 0 (Organometallic Compounds)
RN  - 0199MV609F (gadoteridol)
RN  - 15213-88-4 (gadolinium EDTA)
RN  - 15G12L5X8K (gadobenic acid)
RN  - 6HG8UB2MUY (Meglumine)
RN  - 84F6U3J2R6 (gadodiamide)
RN  - 9004-61-9 (Hyaluronic Acid)
RN  - 9007-34-5 (Collagen)
RN  - 99J2XUF1JT (gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate)
RN  - 9G34HU7RV0 (Edetic Acid)
RN  - AU0V1LM3JT (Gadolinium)
RN  - K2I13DR72L (Gadolinium DTPA)
RN  - RLM74T3Z9D (gadoversetamide)
SB  - IM
MH  - Adult
MH  - Cell Proliferation
MH  - Collagen/biosynthesis
MH  - Contrast Media/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Edetic Acid/pharmacology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Fibroblasts/*drug effects/metabolism
MH  - Gadolinium/*pharmacology
MH  - Gadolinium DTPA/pharmacology
MH  - Heterocyclic Compounds/pharmacology
MH  - Humans
MH  - Hyaluronic Acid/biosynthesis
MH  - Linear Models
MH  - Magnetic Resonance Imaging
MH  - Meglumine/analogs & derivatives/pharmacology
MH  - Middle Aged
MH  - Nephrogenic Fibrosing Dermopathy/chemically induced
MH  - Organometallic Compounds/pharmacology
EDAT- 2010/07/29 06:00
MHDA- 2010/10/01 06:00
CRDT- 2010/07/29 06:00
PHST- 2010/07/29 06:00 [entrez]
PHST- 2010/07/29 06:00 [pubmed]
PHST- 2010/10/01 06:00 [medline]
AID - radiol.10091131 [pii]
AID - 10.1148/radiol.10091131 [doi]
PST - ppublish
SO  - Radiology. 2010 Sep;256(3):735-43. doi: 10.1148/radiol.10091131. Epub 2010 Jul
      27.


PMID- 20663969
OWN - NLM
STAT- MEDLINE
DCOM- 20100930
LR  - 20171116
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 256
IP  - 3
DP  - 2010 Sep
TI  - Hepatocellular carcinoma: signal intensity at gadoxetic acid-enhanced MR
      Imaging--correlation with molecular transporters and histopathologic features.
PG  - 817-26
LID - 10.1148/radiol.10092214 [doi]
AB  - PURPOSE: To analyze the correlation between signal intensity in the hepatobiliary
      phase of gadoxetic acid-enhanced magnetic resonance (MR) imaging and the
      expression of hepatocyte transporters with histopathologic features in
      hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Institutional ethics
      committee approval and informed consent were obtained. Forty surgically resected 
      HCCs were classified as hypointense (n = 32) or iso- or hyperintense (n = 8) on
      the basis of findings in the hepatobiliary phase of gadoxetic acid-enhanced MR
      imaging. The following were compared between hypointense and iso- or hyperintense
      HCCs: the time-signal intensity curves at gadoxetic acid-enhanced MR imaging, the
      expression levels of seven transporters (four organic anion-transporting
      polypeptides [OATPs] and three multidrug-resistant proteins [MRPs]) at polymerase
      chain reaction (PCR) (for 22 nodules), results of immunostaining of OATP8, and
      histologic features. Statistical analysis (unpaired t test, Mann-Whitney test,
      chi(2) test, and Fisher exact test) was performed for each result. RESULTS: On
      the time-signal intensity curves, hypointense HCCs showed a decreasing pattern,
      whereas iso- or hyperintense HCCs showed an increasing pattern after the dynamic 
      phase. PCR revealed that expression of OATP8 (an uptake transporter) in
      hypointense HCCs was lower and that in iso- or hyperintense HCCs was higher than 
      in background liver (P < .001). The expression level of MRP3 (a sinusoidal export
      transporter) showed a similar trend to that of OATP8 (P < .001). Immunostaining
      revealed that OATP8 expression was weak in hypointense HCCs, whereas it was
      sustained in iso- or hyperintense HCCs (P < .001). At histologic examination, a
      pseudoglandular proliferation pattern with bile plugs was more commonly observed 
      in iso- or hyperintense HCCs than in hypointense HCCs (P = .01 for proliferation 
      patterns and P = .006 for bile plugs). CONCLUSION: The enhancement ratio of HCCs 
      in the hepatobiliary phase of gadoxetic acid-enhanced MR imaging positively
      correlated with expression levels of OATP8 and MRP3, indicating that gadoxetic
      acid is taken up by OATP8 and excreted by MRP3.
CI  - (c) RSNA, 2010.
FAU - Kitao, Azusa
AU  - Kitao A
AD  - Department of Radiology, Human Pathology, and Gastroenterology, Kanazawa
      University Graduate School of Medical Science, 13-1 Takaramachi, Kanazawa
      920-8640, Japan. kitao@rad.m.kanazawa-u.ac.jp
FAU - Zen, Yoh
AU  - Zen Y
FAU - Matsui, Osamu
AU  - Matsui O
FAU - Gabata, Toshifumi
AU  - Gabata T
FAU - Kobayashi, Satoshi
AU  - Kobayashi S
FAU - Koda, Wataru
AU  - Koda W
FAU - Kozaka, Kazuto
AU  - Kozaka K
FAU - Yoneda, Norihide
AU  - Yoneda N
FAU - Yamashita, Tatsuya
AU  - Yamashita T
FAU - Kaneko, Shuichi
AU  - Kaneko S
FAU - Nakanuma, Yasuni
AU  - Nakanuma Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100727
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - 0 (Multidrug Resistance-Associated Proteins)
RN  - 0 (Organic Anion Transporters, Sodium-Independent)
RN  - 0 (RNA, Messenger)
RN  - 0 (SLCO1B3 protein, human)
RN  - 0 (Solute Carrier Organic Anion Transporter Family Member 1B3)
RN  - 0 (gadolinium ethoxybenzyl DTPA)
RN  - 1YV0492L5Z (multidrug resistance-associated protein 3)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Hepatocellular/*diagnosis/*metabolism/pathology
MH  - Chi-Square Distribution
MH  - Contrast Media/*pharmacokinetics
MH  - Female
MH  - Gadolinium DTPA/*pharmacokinetics
MH  - Humans
MH  - Immunohistochemistry
MH  - Liver Neoplasms/*diagnosis/*metabolism/pathology
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Multidrug Resistance-Associated Proteins/*metabolism
MH  - Organic Anion Transporters, Sodium-Independent/*metabolism
MH  - RNA, Messenger/metabolism
MH  - Retrospective Studies
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Solute Carrier Organic Anion Transporter Family Member 1B3
MH  - Statistics, Nonparametric
EDAT- 2010/07/29 06:00
MHDA- 2010/10/01 06:00
CRDT- 2010/07/29 06:00
PHST- 2010/07/29 06:00 [entrez]
PHST- 2010/07/29 06:00 [pubmed]
PHST- 2010/10/01 06:00 [medline]
AID - radiol.10092214 [pii]
AID - 10.1148/radiol.10092214 [doi]
PST - ppublish
SO  - Radiology. 2010 Sep;256(3):817-26. doi: 10.1148/radiol.10092214. Epub 2010 Jul
      27.


PMID- 20663968
OWN - NLM
STAT- MEDLINE
DCOM- 20100930
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 256
IP  - 3
DP  - 2010 Sep
TI  - Dynamic contrast-enhanced CT for prostate cancer: relationship between image
      noise, voxel size, and repeatability.
PG  - 976-84
LID - 10.1148/radiol.10092068 [doi]
AB  - PURPOSE: To evaluate the relationship between image noise, voxel size, and
      voxel-wise repeatability of a dynamic contrast agent-enhanced (DCE) computed
      tomographic (CT) examination for prostate cancer. MATERIALS AND METHODS: This
      prospective study was approved by the local research ethics committee, and all
      patients gave written informed consent. Twenty-nine patients (mean age, 69.1
      years; range, 56-80 years) with biopsy-proved prostate cancer underwent two DCE
      CT examinations within 1 week prior to radiation therapy. Parameter maps of
      transfer constant (K(trans)), the fraction of blood plasma (v(p)), the fraction
      of extravascular extracellular space (v(e)), and the flux rate constant between
      the extravascular extracellular space and plasma (k(ep)) were calculated at 15
      different image resolutions, with kernel sizes ranging from 0.002 to 2.57 cm(3). 
      Statistical analysis to quantify the voxel-wise repeatability was performed by
      using a Bland-Altman analysis on all tracer kinetic model parameter maps of each 
      patient. From this analysis, the within-voxel standard deviation (wSD) was
      calculated as a function of spatial resolution. RESULTS: A kernel size in the
      range of 0.1-0.3 cm(3) yields reliable information. At 0.15 cm(3), the median
      wSDs of K(trans), k(ep), v(p), and v(e) are 0.047 min(-1), 0.144 min(-1), 0.011, 
      and 0.104, respectively. With increasing kernel size, these values reach stable
      levels of approximately 0.02 min(-1), 0.05 min(-1), 0.005, and 0.05,
      respectively. CONCLUSION: There is a high voxel-wise repeatability of the DCE CT 
      imaging technique for prostate cancer for kernel sizes as small as 0.1 cm(3).
      With the relationship between kernel size, image noise and voxel-wise
      repeatability, it becomes possible to estimate for alternative DCE CT protocols
      (eg, those with a reduced radiation dose) at what kernel size a sufficient
      repeatability can be obtained.
CI  - (c) RSNA, 2010.
FAU - Korporaal, Johannes G
AU  - Korporaal JG
AD  - Department of Radiotherapy and Radiology, University Medical Center Utrecht, GA
      Utrecht, The Netherlands. J.Korporaal-2@umcutrecht.nl
FAU - van den Berg, Cornelis A T
AU  - van den Berg CA
FAU - Jeukens, Cecile R L P N
AU  - Jeukens CR
FAU - Groenendaal, Greetje
AU  - Groenendaal G
FAU - Moman, Maaike R
AU  - Moman MR
FAU - Luijten, Peter
AU  - Luijten P
FAU - van Vulpen, Marco
AU  - van Vulpen M
FAU - van der Heide, Uulke A
AU  - van der Heide UA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100727
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Contrast Media
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Prostatic Neoplasms/*diagnostic imaging/pathology
MH  - Radiographic Image Interpretation, Computer-Assisted
MH  - Reproducibility of Results
MH  - Statistics, Nonparametric
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2010/07/29 06:00
MHDA- 2010/10/01 06:00
CRDT- 2010/07/29 06:00
PHST- 2010/07/29 06:00 [entrez]
PHST- 2010/07/29 06:00 [pubmed]
PHST- 2010/10/01 06:00 [medline]
AID - radiol.10092068 [pii]
AID - 10.1148/radiol.10092068 [doi]
PST - ppublish
SO  - Radiology. 2010 Sep;256(3):976-84. doi: 10.1148/radiol.10092068. Epub 2010 Jul
      27.


PMID- 20663967
OWN - NLM
STAT- MEDLINE
DCOM- 20101029
LR  - 20220408
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 257
IP  - 1
DP  - 2010 Oct
TI  - Pulmonary emphysema: effect of lung volume on objective quantification at
      thin-section CT.
PG  - 260-8
LID - 10.1148/radiol.10091446 [doi]
AB  - PURPOSE: To prospectively investigate the effect of submaximal inspiration on
      computed tomographic (CT) indexes used to quantify emphysema and to discriminate 
      between effects of lung tissue loss and increase in total lung capacity (TLC) on 
      these indexes. MATERIALS AND METHODS: In this ethical committee-approved study,
      20 control subjects and 16 patients with chronic obstructive pulmonary disease
      (COPD) who provided written informed consent were included. Three 1-mm-thick
      sections were obtained from each participant at 100%, 90%, 80%, 70%, and 50% of
      vital capacity (VC). At each volume, eight percentiles of attenuation
      distribution, as well as relative area (RA) of lung occupied by attenuation
      coefficients lower than nine thresholds, were calculated. A linear regression
      line between TLC and each CT index was plotted for control subjects. Mean
      distance from data points measured in patients with COPD to the normal regression
      line was used to reflect the effect of lung tissue loss, regardless of TLC.
      RESULTS: The RA of lung occupied by attenuation coefficients lower than -950 HU
      (RA(950)) at any percentage of VC lower than 100% decreased significantly from
      that at 100% VC (P </= .002) in control subjects and patients with COPD; however,
      between 100% VC and 90% VC, the average difference in RA(950) was only 3% and 2% 
      in control subjects and patients with COPD, respectively. The 1st percentile at
      any percentage of VC lower than 100% increased from that at 100% VC (P < .001) in
      control subjects. This percentile did not significantly differ from 100% VC at
      90% VC or 80% VC (P = .176 and P = 0.077, respectively), but it did significantly
      differ from 100% VC at 70% VC and 50% VC (P </= .002 for both) in patients with
      COPD. Slope and mean distance were different from zero for all RAs and
      percentiles except for mean distance for RAs between RA(900) and RA(920).
      CONCLUSION: Submaximal inspiration induces underestimation of pulmonary
      emphysema. Both lung tissue loss and TLC influence CT indexes, suggesting the
      need to establish normal CT values.
FAU - Madani, Afarine
AU  - Madani A
AD  - Department of Radiology, Hopital Erasme, Universite Libre de Bruxelles, Brussels,
      Belgium. afarine@ladner-madani.com
FAU - Van Muylem, Alain
AU  - Van Muylem A
FAU - Gevenois, Pierre Alain
AU  - Gevenois PA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100727
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
CIN - Radiology. 2011 May;259(2):610-1; author reply 611-2. PMID: 21502395
MH  - Adult
MH  - Case-Control Studies
MH  - Diving
MH  - Female
MH  - Humans
MH  - Linear Models
MH  - Lung Volume Measurements
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Pulmonary Emphysema/*diagnostic imaging/pathology
MH  - Respiratory Function Tests
MH  - Statistics, Nonparametric
MH  - Tomography, X-Ray Computed/*methods
MH  - Vital Capacity
EDAT- 2010/07/29 06:00
MHDA- 2010/10/30 06:00
CRDT- 2010/07/29 06:00
PHST- 2010/07/29 06:00 [entrez]
PHST- 2010/07/29 06:00 [pubmed]
PHST- 2010/10/30 06:00 [medline]
AID - radiol.10091446 [pii]
AID - 10.1148/radiol.10091446 [doi]
PST - ppublish
SO  - Radiology. 2010 Oct;257(1):260-8. doi: 10.1148/radiol.10091446. Epub 2010 Jul 27.


PMID- 20663941
OWN - NLM
STAT- MEDLINE
DCOM- 20110317
LR  - 20101124
IS  - 1049-7323 (Print)
IS  - 1049-7323 (Linking)
VI  - 20
IP  - 12
DP  - 2010 Dec
TI  - Holding harm: narrative methods in mental health research on refugee trauma.
PG  - 1664-76
LID - 10.1177/1049732310376521 [doi]
AB  - In this article, we question narrative inquiry's predominant ethics of benefit
      when engaging in narrative research on trauma and social suffering. Through a
      particular focus on the use of a narrative methodology in a refugee health study,
      we explore the potential risk and protective function of narrative trauma
      research with vulnerable respondents. A review of ethical questions emerging
      during the course of a multiple-case study with refugee families documents how
      narrative methods' characteristics clearly revisit the impact of traumatization
      on autonomy, narrativity, and relationship building in participants and, thus,
      evoke the replay of traumatic experience within the research relationship itself.
      Blurring a straightforward ethics of benefit, this reactivation of trauma
      accounts for the research relationship's balancing movement between reiterating
      and transforming traumatic distress, and urges for the need to contain coexisting
      aspects of both harm and benefit in developing narrative research with
      traumatized participants.
FAU - De Haene, Lucia
AU  - De Haene L
AD  - Katholieke Universiteit Leuven, Faculty of Psychology and Educational Sciences,
      Leuven, Belgium. lucia.dehaene@psy.kuleuven.be
FAU - Grietens, Hans
AU  - Grietens H
FAU - Verschueren, Karine
AU  - Verschueren K
LA  - eng
PT  - Journal Article
DEP - 20100727
PL  - United States
TA  - Qual Health Res
JT  - Qualitative health research
JID - 9202144
MH  - Ethics, Research
MH  - Family/*psychology
MH  - Human Rights Abuses/psychology
MH  - Humans
MH  - Intergenerational Relations
MH  - *Narration
MH  - *Principle-Based Ethics
MH  - Qualitative Research
MH  - Refugees/*psychology
MH  - Researcher-Subject Relations/*ethics
MH  - Stress Disorders, Post-Traumatic/*psychology
MH  - Violence/psychology
MH  - Vulnerable Populations
EDAT- 2010/07/29 06:00
MHDA- 2011/03/18 06:00
CRDT- 2010/07/29 06:00
PHST- 2010/07/29 06:00 [entrez]
PHST- 2010/07/29 06:00 [pubmed]
PHST- 2011/03/18 06:00 [medline]
AID - 1049732310376521 [pii]
AID - 10.1177/1049732310376521 [doi]
PST - ppublish
SO  - Qual Health Res. 2010 Dec;20(12):1664-76. doi: 10.1177/1049732310376521. Epub
      2010 Jul 27.


PMID- 20663771
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20181201
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 8
DP  - 2010 Aug
TI  - Ethics and law teaching and learning in undergraduate medicine.
PG  - 511
LID - 10.1136/jme.2010.036350 [doi]
AB  - The updated consensus report on undergraduate medical education (1) provides an
      extensive framework for teaching ethics and law. However, there is a need for
      further research into the indicators of good progress towards sound moral
      reasoning and action to take into account personal and professional developmental
      trajectories. The report indicates competencies which should be demonstrable by
      students: additional consideration needs to be given to those competencies which 
      institutions should be able to demonstrate in relation to the provision made for 
      students and teachers.
FAU - Sutton, A
AU  - Sutton A
AD  - Manchester Medical School, University of Manchester, Manchester, UK.
      adrian.sutton@manchester.ac.uk
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
CON - J Med Ethics. 2010 Jan;36(1):55-60. PMID: 20026695
MH  - *Clinical Medicine
MH  - Education, Medical, Undergraduate/*methods
MH  - Ethics, Medical/*education
MH  - Humans
MH  - Schools, Medical/*standards
EDAT- 2010/07/29 06:00
MHDA- 2011/11/09 06:00
CRDT- 2010/07/29 06:00
PHST- 2010/07/29 06:00 [entrez]
PHST- 2010/07/29 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - 36/8/511 [pii]
AID - 10.1136/jme.2010.036350 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Aug;36(8):511. doi: 10.1136/jme.2010.036350.


PMID- 20663769
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20141120
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 8
DP  - 2010 Aug
TI  - Between the needy and the greedy: the quest for a just and fair ethics of
      clinical research.
PG  - 500-4
LID - 10.1136/jme.2009.032656 [doi]
AB  - The acceleration of the market globalisation process over the last three decades 
      has internationalised clinical research and influenced both the way in which it
      is funded and the development and application of research practices. In addition,
      in recent years international multicentre randomised clinical trials have become 
      the model par excellence for research on new medicines. The neoliberal model of
      globalisation has induced a decline in state power, both with regard to
      establishing national research for health priorities and to influencing the
      development of adequate ethical guidelines to protect human beings that
      participate in multinational research. In this respect, poor and low-income
      countries, which lack sustainable control and review systems to deal with the
      ethical and methodological challenges of complex studies conducted by researchers
      from affluent countries and funded by large multinational pharmaceutical
      companies, are particularly vulnerable. The aim of the present paper is to
      explore critically some of the actual and possible ethical pitfalls of
      globalisation of clinical research and propose mechanisms for turning
      transnational clinical research into a more cooperative and fairer enterprise.
FAU - Garrafa, Volnei
AU  - Garrafa V
AD  - UNESCO Chair of Bioethics-Post-Graduation Program of Bioethics, Public Health
      Department, Faculty of Health Sciences, University of Brasilia, Brasilia, Federal
      District, Brazil. volnei@unb.br
FAU - Solbakk, Jan Helge
AU  - Solbakk JH
FAU - Vidal, Susana
AU  - Vidal S
FAU - Lorenzo, Claudio
AU  - Lorenzo C
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Clinical Trials as Topic
MH  - Female
MH  - Global Health
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - International Cooperation
MH  - Male
MH  - Patient Selection/*ethics
MH  - Research Subjects/*economics/psychology
EDAT- 2010/07/29 06:00
MHDA- 2011/11/09 06:00
CRDT- 2010/07/29 06:00
PHST- 2010/07/29 06:00 [entrez]
PHST- 2010/07/29 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - 36/8/500 [pii]
AID - 10.1136/jme.2009.032656 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Aug;36(8):500-4. doi: 10.1136/jme.2009.032656.


PMID- 20663766
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20100728
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 8
DP  - 2010 Aug
TI  - Defending human enhancement technologies: unveiling normativity.
PG  - 483-7
LID - 10.1136/jme.2010.036095 [doi]
AB  - Recent advances in biotechnologies have led to speculations about enhancing human
      beings. Many of the moral arguments presented to defend human enhancement
      technologies have been limited to discussions of their risks and benefits. The
      author argues that in so far as ethical arguments focus primarily on risks and
      benefits of human enhancement technologies, these arguments will be insufficient 
      to provide a robust defence of these technologies. This is so because the belief 
      that an assessment of risks and benefits is a sufficient ethical evaluation of
      these technologies incorrectly presupposes that risk assessments do not involve
      value judgements. Second, it presupposes a reductionist conception of ethics as
      merely a risk management instrument. Each of these assumptions separates ethical 
      evaluation from discussion and appraisal of ends and means and thus leaves
      important--indeed, essential--ethical considerations out of view. Once these
      problematic assumptions are rejected, it becomes clear that an adequate defence
      of human enhancement technologies requires more than a simple balance of their
      risks and benefits.
FAU - de Melo-Martin, Inmaculada
AU  - de Melo-Martin I
AD  - Division of Medical Ethics, Department of Public Health, Weill Cornell Medical
      College, New York, NY 10065, USA. imd2001@med.cornell.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Biomedical Enhancement/*ethics
MH  - *Ethics, Medical
MH  - Human Characteristics
MH  - Human Development
MH  - Humans
MH  - Risk Assessment/*ethics
EDAT- 2010/07/29 06:00
MHDA- 2011/11/09 06:00
CRDT- 2010/07/29 06:00
PHST- 2010/07/29 06:00 [entrez]
PHST- 2010/07/29 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - 36/8/483 [pii]
AID - 10.1136/jme.2010.036095 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Aug;36(8):483-7. doi: 10.1136/jme.2010.036095.


PMID- 20663765
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20100728
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 8
DP  - 2010 Aug
TI  - Maps of beauty and disease: thoughts on genetics, confidentiality, and biological
      family.
PG  - 479-82
LID - 10.1136/jme.2009.033514 [doi]
AB  - The author explores the ethics of decision-making and confidentiality in donor
      insemination through the narrative of her experience having two children with a
      sperm donor who was later discovered to carry a gene for a serious heart disease,
      hypertrophic cardiomyopathy. Contrasting individualist and communitarian ethical 
      models, she questions understandings of confidentiality that hamper the
      construction of a medical family tree, especially when prognosis and treatment
      depend on the larger familial profile of the disease. She also emphasises that
      for the patient family the discovery of biological family through the lens of
      transmitted illness leads to a shift in family identity that goes beyond the
      purely medical.
FAU - Ladd, Mary
AU  - Ladd M
AD  - JME Editorial Office, BMJ Publishing Group Ltd, BMA House, Tavistock Square,
      London, UK. jme@bmjgroup.com
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Beauty
MH  - Cardiomyopathy, Hypertrophic, Familial/*genetics
MH  - Confidentiality/*ethics
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genetic Privacy/ethics
MH  - Genetic Testing
MH  - Humans
MH  - Insemination, Artificial, Heterologous/*ethics/legislation & jurisprudence
MH  - Male
MH  - Molecular Diagnostic Techniques
MH  - Pedigree
MH  - Sperm Banks
MH  - Truth Disclosure/ethics
EDAT- 2010/07/29 06:00
MHDA- 2011/11/09 06:00
CRDT- 2010/07/29 06:00
PHST- 2010/07/29 06:00 [entrez]
PHST- 2010/07/29 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - 36/8/479 [pii]
AID - 10.1136/jme.2009.033514 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Aug;36(8):479-82. doi: 10.1136/jme.2009.033514.


PMID- 20663764
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20100728
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 8
DP  - 2010 Aug
TI  - End-of-life decisions as bedside rationing. An ethical analysis of life support
      restrictions in an Indian neonatal unit.
PG  - 473-8
LID - 10.1136/jme.2010.035535 [doi]
AB  - INTRODUCTION: Hundreds of thousands of premature neonates born in low-income
      countries are implicitly denied treatment each year. Studies from India show that
      treatment is rationed even for neonates born at 32 gestational age weeks (GAW),
      and multiple external factors influence treatment decisions. Is withholding of
      life-saving treatment for children born between 28 and 32 GAW acceptable from an 
      ethical perspective? METHOD: A seven-step impartial ethical analysis, including
      outcome analysis of four accepted priority criteria: severity of disease,
      treatment effect, cost effectiveness and evidence for neonates born at 28 and 32 
      GAW. RESULTS: The ethical analysis sketches out two possibilities: (a) It is not 
      ethically permissible to limit treatment to neonates below 32 GAW when assigning 
      high weight to health maximisation and overall health equality. Neonates below 32
      GAW score high on severity of disease and efficiency and cost-effectiveness of
      treatment if one gives full weight to early years of a newborn life. It is in the
      child's best interest to be treated. (b) It can be considered ethically
      permissible if high weight is assigned to reducing inequality of welfare and
      maximising overall welfare and/or not granting full weight to early years of
      newborns is considered acceptable. From an equity-motivated health and welfare
      perspective, we would not accept (b), as it relies on accepting the lack of
      proper welfare policies for the poor and disabled in India. CONCLUSION: Explicit 
      priority processes in India for financing neonatal care are needed. If premature 
      neonates are perceived as worth less than other patient groups, the reasons
      should be explored among a broad range of stakeholders.
FAU - Miljeteig, I
AU  - Miljeteig I
AD  - Global Health; Ethics, Economics and Culture, Department of Public Health and
      Primary Health Care and Centre for International Health, University of Bergen,
      Bergen, Norway. ingrid.miljeteig@isf.uib.no
FAU - Johansson, K A
AU  - Johansson KA
FAU - Sayeed, S A
AU  - Sayeed SA
FAU - Norheim, O F
AU  - Norheim OF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Birth Weight
MH  - Cross-Cultural Comparison
MH  - Decision Making
MH  - *Ethics, Medical
MH  - Euthanasia, Passive/ethics
MH  - Female
MH  - Gestational Age
MH  - Health Care Rationing/*ethics
MH  - Humans
MH  - India
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Intensive Care Units, Neonatal/economics/*ethics
MH  - Life Support Care/*ethics
MH  - Male
MH  - Patient Selection
MH  - Prognosis
MH  - Socioeconomic Factors
MH  - Terminal Care/*ethics
EDAT- 2010/07/29 06:00
MHDA- 2011/11/09 06:00
CRDT- 2010/07/29 06:00
PHST- 2010/07/29 06:00 [entrez]
PHST- 2010/07/29 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - 36/8/473 [pii]
AID - 10.1136/jme.2010.035535 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Aug;36(8):473-8. doi: 10.1136/jme.2010.035535.


PMID- 20663763
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20161125
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 8
DP  - 2010 Aug
TI  - Ethical lessons from the 'undercover nurse': implications for practice and
      leadership.
PG  - 469-72
LID - 10.1136/jme.2010.035626 [doi]
AB  - BACKGROUND: The case of Margaret Haywood, the 'undercover nurse', is a
      significant one for the UK's National Health Service (NHS). She investigated
      complaints made about the Royal Sussex County Hospital and covertly filmed
      inpatients experiencing care detrimental to their health. The material was
      subsequently broadcast on the BBC's Panorama programme. It caused a scandal and
      brought about changes at the hospital, as well a demand for greater clinical
      leadership. Margaret Haywood was, however, struck off the nursing register for
      breaching confidentiality and because of the methods she used to blow the
      whistle. METHODS: The authors apply the ethical lenses of purpose, principle,
      people and power to explore this case. RESULTS: This is a morally ambiguous
      situation in which both the protagonist and the organisation compromised their
      core values. The undercover nurse used individuals as a means to a 'higher' end, 
      and the Brighton and Sussex University Hospitals NHS Trust are seen to have
      deviated from the ethical to the business map, in a contradiction of what the
      health service represents. CONCLUSIONS: These deficits can be repaired by
      reinforcement of the ethics of duty and ideals on a practical level and the
      involvement of clinicians to lead at a management level, to act as a moral
      compass.
FAU - Grant, Paul
AU  - Grant P
AD  - Brighton Business School, University of Brighton, Moulsecoomb Campus, Brighton,
      East Sussex, UK. drpaul.grant@doctors.org.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Attitude of Health Personnel
MH  - Confidentiality/*ethics
MH  - Geriatric Nursing/ethics/organization & administration/*standards
MH  - Humans
MH  - Informed Consent/ethics
MH  - Licensure, Nursing/*ethics
MH  - Nurse's Role
MH  - Professional Misconduct/*ethics
MH  - Quality of Health Care/*ethics/organization & administration/standards
MH  - Television/ethics
MH  - United Kingdom
MH  - Whistleblowing/*ethics/psychology
EDAT- 2010/07/29 06:00
MHDA- 2011/11/09 06:00
CRDT- 2010/07/29 06:00
PHST- 2010/07/29 06:00 [entrez]
PHST- 2010/07/29 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - 36/8/469 [pii]
AID - 10.1136/jme.2010.035626 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Aug;36(8):469-72. doi: 10.1136/jme.2010.035626.


PMID- 20663762
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20151119
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 8
DP  - 2010 Aug
TI  - Irish views on death and dying: a national survey.
PG  - 454-8
LID - 10.1136/jme.2009.032615 [doi]
AB  - OBJECTIVE: To determine the public's understanding of and views about a range of 
      ethical issues in relation to death and dying. DESIGN: Random, digit-dialing,
      telephone interview SETTING: Ireland. PARTICIPANTS: 667 adult individuals.
      RESULTS: The general public are unfamiliar with terms associated with end-of-life
      care. Although most want to be informed if they have a terminal illness, they
      also value family support in this regard. Most of the respondents believe that
      competent patients have the right to refuse life-saving treatment. Most also
      (mistakenly) believe that families, either alone or with physicians, have the
      authority to make decisions about starting or stopping treatment for incompetent 
      patients. Most Irish people are more concerned about the quality of their dying
      than death itself. Religious commitment is important to most Irish people, and
      this impacts on their views about medical treatment and care at the end of life. 
      CONCLUSIONS: The study paints a picture of a general public that is not very
      comfortable with or informed about the processes of dying and death. Great
      sensitivity is required of health professionals who must negotiate the timing and
      the context of breaking of bad news with patients and families. Educational
      interventions, public and organisational policies and legislation need to address
      the uncertainty that surrounds the role of professionals and families in making
      decisions for dying patients.
FAU - McCarthy, J
AU  - McCarthy J
AD  - School of Nursing and Midwifery, Brookfield Health Sciences Complex, University
      College Cork, Cork, Ireland. j.mccarthy@ucc.ie
FAU - Weafer, J
AU  - Weafer J
FAU - Loughrey, M
AU  - Loughrey M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Attitude to Death
MH  - Female
MH  - Health Care Surveys
MH  - Humans
MH  - Informed Consent/psychology
MH  - Ireland
MH  - Male
MH  - Middle Aged
MH  - Patient Advocacy/psychology
MH  - Religion and Medicine
MH  - Surveys and Questionnaires
MH  - Terminal Care/*psychology
MH  - Terminally Ill/psychology
MH  - Young Adult
EDAT- 2010/07/29 06:00
MHDA- 2011/11/09 06:00
CRDT- 2010/07/29 06:00
PHST- 2010/07/29 06:00 [entrez]
PHST- 2010/07/29 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - 36/8/454 [pii]
AID - 10.1136/jme.2009.032615 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Aug;36(8):454-8. doi: 10.1136/jme.2009.032615.


PMID- 20663759
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20161125
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 9
DP  - 2010 Sep
TI  - A case of insufficient evidence equipoise: the NICE guidance on antibiotic
      prophylaxis for the prevention of infective endocarditis.
PG  - 567-70
LID - 10.1136/jme.2010.036848 [doi]
AB  - This paper argues that the National Institute for Health and Clinical Excellence 
      should not offer guidance in situations where there is insufficient evidence
      equipoise about the potential benefit of the treatment in question. This is
      broadly for two reasons. First, without knowing if the treatment is effective no 
      cost-effectiveness judgement can be logically made. Second, the implementation of
      a population wide change in treatment where there is equipoise amounts to a de
      facto clinical trial that falls outside the Clinical Trials Regulations. As such 
      there are strong ethical and possibly legal grounds for preventing such an
      outcome. Guidance based upon insufficient evidence equipoise also impacts upon
      the clinical discretion possessed by individual medical professionals.
FAU - Mohindra, R K
AU  - Mohindra RK
AD  - raj.mohindra1@googlemail.com
LA  - eng
PT  - Journal Article
DEP - 20100726
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Antibiotic Prophylaxis/economics/*methods
MH  - *Clinical Trials as Topic
MH  - Cost-Benefit Analysis
MH  - Endocarditis/economics/*prevention & control
MH  - Humans
MH  - *Practice Guidelines as Topic
MH  - Risk Factors
MH  - *Therapeutic Equipoise
MH  - United Kingdom
EDAT- 2010/07/29 06:00
MHDA- 2011/11/16 06:00
CRDT- 2010/07/29 06:00
PHST- 2010/07/29 06:00 [entrez]
PHST- 2010/07/29 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - jme.2010.036848 [pii]
AID - 10.1136/jme.2010.036848 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Sep;36(9):567-70. doi: 10.1136/jme.2010.036848. Epub 2010 Jul 
      26.


PMID- 20663758
OWN - NLM
STAT- MEDLINE
DCOM- 20110225
LR  - 20101022
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 11
DP  - 2010 Nov
TI  - A case study from the perspective of medical ethics: refusal of treatment in an
      ambulance.
PG  - 652-5
LID - 10.1136/jme.2010.035600 [doi]
AB  - This paper will examine a sample case encountered by ambulance staff in the
      context of the basic principles of medical ethics. An accident takes place on an 
      intercity highway. Ambulance staff pick up the injured driver and medical
      intervention is initiated. The driver suffers from a severe stomach ache, which
      is also affecting his back. Evaluating the patient, the ambulance doctor suspects
      that he might be experiencing internal bleeding. For this reason, venous access, 
      in the doctor's opinion, should be achieved and the patient should be quickly
      started on an intravenous serum. The patient, however, who has so far kept his
      silence, objects to the administration of the serum. The day this is taking place
      is within the month of Ramadan and the patient is fasting. The patient states
      that he is fasting and that his fast will be broken and his religious practice
      disrupted in the event that the serum is administered. The ambulance doctor
      informs him that his condition is life-threatening and that the serum must be
      administered immediately. The patient now takes a more vehement stand. 'If I am
      to die, I want to die while I am fasting. Today is Friday and I have always
      wanted to die on such a holy day,' he says. The ambulance physician has little
      time to decide. How should the patient be treated? Which type of behaviour will
      create the least erosion of his values?
FAU - Erbay, Hasan
AU  - Erbay H
AD  - Department of Deontology and History of Medicine, Cukurova University, Adana,
      Turkey. hasanerbay@yahoo.com
FAU - Alan, Sultan
AU  - Alan S
FAU - Kadioglu, Selim
AU  - Kadioglu S
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20100726
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Accidents, Traffic
MH  - Ambulances
MH  - *Attitude
MH  - Bioethical Issues
MH  - Blood Transfusion/ethics
MH  - Communication
MH  - Decision Making
MH  - Emergency Medical Services/*ethics
MH  - Fasting
MH  - Humans
MH  - Islam/psychology
MH  - Male
MH  - *Personal Autonomy
MH  - Physician-Patient Relations
MH  - *Religion and Medicine
MH  - Treatment Refusal/*ethics
MH  - Turkey
EDAT- 2010/07/29 06:00
MHDA- 2011/02/26 06:00
CRDT- 2010/07/29 06:00
PHST- 2010/07/29 06:00 [entrez]
PHST- 2010/07/29 06:00 [pubmed]
PHST- 2011/02/26 06:00 [medline]
AID - jme.2010.035600 [pii]
AID - 10.1136/jme.2010.035600 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Nov;36(11):652-5. doi: 10.1136/jme.2010.035600. Epub 2010 Jul 
      26.


PMID- 20663756
OWN - NLM
STAT- MEDLINE
DCOM- 20110225
LR  - 20161125
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 11
DP  - 2010 Nov
TI  - Prepared for practice? Law teaching and assessment in UK medical schools.
PG  - 694-9
LID - 10.1136/jme.2010.036640 [doi]
AB  - A revised core curriculum for medical ethics and law in UK medical schools has
      been published. The General Medical Council requires medical graduates to
      understand law and ethics and behave in accordance with ethical and legal
      principles. A parallel policy agenda emphasises accountability, the development
      of professionalism and patient safety. Given the renewed focus on teaching and
      learning law alongside medical ethics and the development of professional
      identity, this survey aimed to identify how medical schools are responding to the
      preparation of medical students for practice in the future. Questions were asked 
      about the location, content and methods of teaching and assessment of law in
      undergraduate medical education. Examples of course documentation were requested 
      to illustrate the approaches being taken. A 76% response rate was achieved. Most 
      responding schools integrate law teaching with medical ethics, emphasising both
      the acquisition of knowledge and its application in a clinical context. Teaching,
      learning and assessment of law in clinical attachments is much less formalised
      than that in non-clinical education. Coverage of recommended topic areas varies, 
      raising questions about the degree to which students can embed their knowledge
      and skills in actual practice. More positively, teaching does not rely on single 
      individuals and clear descriptions were offered for problem-based and small group
      case-based learning. Further research is required to explore whether there are
      optimum ways of ensuring that legal knowledge, and skills in its use, form part
      of the development of professionalism among doctors in training.
FAU - Preston-Shoot, Michael
AU  - Preston-Shoot M
AD  - Faculty of Health and Social Sciences, University of Bedfordshire, Luton, UK.
      michael.preston-shoot@beds.ac.uk
FAU - McKimm, Judy
AU  - McKimm J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100726
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Clinical Medicine/education/legislation & jurisprudence
MH  - Curriculum/standards
MH  - Education, Medical, Undergraduate/*methods/standards
MH  - Ethics, Medical/*education
MH  - Humans
MH  - Schools, Medical/*standards
MH  - Surveys and Questionnaires
MH  - Teaching/methods
MH  - United Kingdom
EDAT- 2010/07/29 06:00
MHDA- 2011/02/26 06:00
CRDT- 2010/07/29 06:00
PHST- 2010/07/29 06:00 [entrez]
PHST- 2010/07/29 06:00 [pubmed]
PHST- 2011/02/26 06:00 [medline]
AID - jme.2010.036640 [pii]
AID - 10.1136/jme.2010.036640 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Nov;36(11):694-9. doi: 10.1136/jme.2010.036640. Epub 2010 Jul 
      26.


PMID- 20663754
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20211020
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 10
DP  - 2010 Oct
TI  - Problem-based learning for professionalism and scientific integrity training of
      biomedical graduate students: process evaluation.
PG  - 620-6
LID - 10.1136/jme.2009.035238 [doi]
AB  - OBJECTIVE: We conducted a process evaluation to (a) assess the effectiveness of a
      new problem-based learning curriculum designed to teach professionalism and
      scientific integrity to biomedical graduate students and (b) modify the course to
      enhance its relevance and effectiveness. The content presented realistic cases
      and issues in the practice of science, to promote skill development and to
      acculturate students to professional norms of science. METHOD: We used 5-step
      Likert-scaled questions, open-ended questions, and interviews of students and
      facilitators to assess curricular effectiveness. RESULTS: Both facilitators and
      students perceived course objectives were achieved. For example, respondents
      preferred active learning over lectures; both faculty and students perceived that
      the curriculum increased their understanding of norms, role obligations and
      responsibilities of professional scientists. They also reported an increased
      ability to identify ethical situations and felt that they had developed skills in
      moral reasoning and effective group work. CONCLUSIONS: These data helped to
      improve course implementation and instructional material. For example, to correct
      a negative perception that this was an 'ethics' course, we redesigned case
      debriefing activities to reinforce learning objectives and important skills. We
      refined cases to be more engaging and relevant for students, and gave
      facilitators more specific training and resources for each case. The
      problem-based learning small group strategy can stimulate an environment whereby 
      participants are more aware of ethical implications of science, and increase
      their socialisation and open communication about professional behaviour.
FAU - Jones, Nancy L
AU  - Jones NL
AD  - Division Public Health Sciences, Wake Forest University Health Sciences, North
      Carolina, USA. jonesna@niaid.nih.gov
FAU - Peiffer, Ann M
AU  - Peiffer AM
FAU - Lambros, Ann
AU  - Lambros A
FAU - Eldridge, J Charles
AU  - Eldridge JC
LA  - eng
GR  - F32 NS054472/NS/NINDS NIH HHS/United States
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20100726
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Attitude of Health Personnel
MH  - Biomedical Research/education/ethics
MH  - Consumer Behavior
MH  - Curriculum/*standards
MH  - Education, Medical, Graduate/*methods/organization & administration
MH  - Ethics, Medical/*education
MH  - Problem-Based Learning/*methods
MH  - Professional Competence/standards
MH  - Professional Practice/*standards
MH  - Surveys and Questionnaires
PMC - PMC3752918
MID - NIHMS402458
EDAT- 2010/07/29 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/07/29 06:00
PHST- 2010/07/29 06:00 [entrez]
PHST- 2010/07/29 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - jme.2009.035238 [pii]
AID - 10.1136/jme.2009.035238 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Oct;36(10):620-6. doi: 10.1136/jme.2009.035238. Epub 2010 Jul 
      26.


PMID- 20663753
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20100906
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 9
DP  - 2010 Sep
TI  - Exceptional know how? Possible pitfalls of routinising genetic services.
PG  - 529-33
LID - 10.1136/jme.2009.035253 [doi]
AB  - Genetic testing practices are increasingly advancing clinical medicine. This
      process of 'routinisation of genetics' has been conceived as a medical and
      ethical problem mainly because of the assumption that non-geneticists might lack 
      the necessary skills to provide these services. In particular, the relevant
      theoretical knowledge in clinical genetics is viewed as insufficient in general
      practitioners and physicians from other specialities. Empirical findings seem to 
      indicate significant variations not only in theoretical but also in practical
      knowledge between geneticists and non-geneticists. Several fields of practical
      knowledge-regarding for example the focus of clinical action, the relevance of
      therapeutic action or the normative framework-can be identified that are or could
      be areas of conflict when the routinisation of genetic services proceeds. From an
      ethical point of view, these variations in know how and background are especially
      relevant whenever the respective genetic service is concerned with medical
      information of exceptional normative quality, such as, for example, in prenatal
      genetic screening and diagnosis of untreatable conditions. Here, the clinically
      acquired practical knowledge of the non-geneticist could be particularly
      misleading insofar as there is no relation to therapy and-in a narrow sense-no
      clinical utility to be assessed. Non-geneticists need a chance to acquire the
      relevant theoretical and practical knowledge in order to understand and fulfil
      their own duties in the respective situations in a way that secures the important
      rights at stake of their patients and clients.
FAU - Schmitz, Dagmar
AU  - Schmitz D
AD  - Ethics Institute, Utrecht University, Heidelberglaan 8, Utrecht 3584 CS, The
      Netherlands. daschmitz@ukaachen.de
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100726
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Clinical Competence
MH  - Genetic Predisposition to Disease/*psychology
MH  - Genetic Services/*ethics
MH  - Genetics, Medical/*ethics
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Physician's Role/*psychology
MH  - Truth Disclosure/ethics
EDAT- 2010/07/29 06:00
MHDA- 2011/11/16 06:00
CRDT- 2010/07/29 06:00
PHST- 2010/07/29 06:00 [entrez]
PHST- 2010/07/29 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - jme.2009.035253 [pii]
AID - 10.1136/jme.2009.035253 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Sep;36(9):529-33. doi: 10.1136/jme.2009.035253. Epub 2010 Jul 
      26.


PMID- 20663643
OWN - NLM
STAT- MEDLINE
DCOM- 20110124
LR  - 20101004
IS  - 1873-3379 (Electronic)
IS  - 0891-4222 (Linking)
VI  - 31
IP  - 6
DP  - 2010 Nov-Dec
TI  - An overview of intervention options for promoting adaptive behavior of persons
      with acquired brain injury and minimally conscious state.
PG  - 1121-34
LID - 10.1016/j.ridd.2010.06.019 [doi]
AB  - This paper presents an overview of the studies directed at helping post-coma
      persons with minimally conscious state improve their adaptive behavior.
      Twenty-one studies were identified for the 2000-2010 period (i.e., a period in
      which an intense debate has occurred about diagnostic, rehabilitative,
      prognostic, and ethical issues concerning people with severe acquired brain
      injury). Three of the 21 studies involved transcortical magnetic or deep brain
      stimulation. Six studies focused on the provision of multisensory stimulation or 
      music therapy. The remaining 12 studies involved the use of response-related
      (contingent) stimulation and assistive technology. The outcomes of the studies,
      which were generally reported as positive, were discussed in terms of (a) the
      size (quantitative relevance) of the changes obtained, (b) the
      credibility/reliability of the changes, in light of the methodological conditions
      of the studies, and (c) the level of engagement and interaction involvement of
      the participants. Relevant issues for future research were also examined.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Lancioni, Giulio E
AU  - Lancioni GE
AD  - University of Bari, Italy. g.lancioni@psico.uniba.it
FAU - Bosco, Andrea
AU  - Bosco A
FAU - Belardinelli, Marta Olivetti
AU  - Belardinelli MO
FAU - Singh, Nirbhay N
AU  - Singh NN
FAU - O'Reilly, Mark F
AU  - O'Reilly MF
FAU - Sigafoos, Jeff
AU  - Sigafoos J
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100721
PL  - United States
TA  - Res Dev Disabil
JT  - Research in developmental disabilities
JID - 8709782
SB  - IM
MH  - *Adaptation, Psychological
MH  - *Brain Injury, Chronic/psychology/rehabilitation/therapy
MH  - *Communication Aids for Disabled
MH  - *Deep Brain Stimulation
MH  - Humans
MH  - *Persistent Vegetative State/psychology/rehabilitation/therapy
EDAT- 2010/07/29 06:00
MHDA- 2011/01/25 06:00
CRDT- 2010/07/29 06:00
PHST- 2010/06/15 00:00 [received]
PHST- 2010/06/22 00:00 [accepted]
PHST- 2010/07/29 06:00 [entrez]
PHST- 2010/07/29 06:00 [pubmed]
PHST- 2011/01/25 06:00 [medline]
AID - S0891-4222(10)00153-8 [pii]
AID - 10.1016/j.ridd.2010.06.019 [doi]
PST - ppublish
SO  - Res Dev Disabil. 2010 Nov-Dec;31(6):1121-34. doi: 10.1016/j.ridd.2010.06.019.
      Epub 2010 Jul 21.


PMID- 20663560
OWN - NLM
STAT- MEDLINE
DCOM- 20110118
LR  - 20100906
IS  - 1873-6386 (Electronic)
IS  - 0160-2527 (Linking)
VI  - 33
IP  - 4
DP  - 2010 Sep-Oct
TI  - Problem-solving courts in Canada: A review and a call for empirically-based
      evaluation methods.
PG  - 258-64
LID - 10.1016/j.ijlp.2010.06.008 [doi]
AB  - While problem-solving courts may soon become permanent fixtures within the
      criminal justice system in Canada, little is actually known of their
      effectiveness in dealing with crime. The current paper will review the
      fundamental basis for these court models, with special attention on their arrival
      in Canada. The focus will be on three particular forms of problem-solving courts 
      - mental health court, drug treatment court and community court - due in large
      part to the availability of literature. Existing evaluations, both process and
      outcome, of both the Canadian and American models will be discussed and their
      inadequacies addressed. It is hoped that this article will serve to dispel myths 
      surrounding the ethical application of random assignment when evaluating these
      court systems. Through the application of experimental methodology, evaluations
      may finally be able to address the issue of whether these court systems are
      effective alternatives to the traditional criminal justice stream.
CI  - Copyright 2010 Elsevier Ltd. All rights reserved.
FAU - Slinger, Emily
AU  - Slinger E
AD  - Simon Fraser University, Burnaby, BC, Canada.
FAU - Roesch, Ronald
AU  - Roesch R
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Int J Law Psychiatry
JT  - International journal of law and psychiatry
JID - 7806862
SB  - IM
MH  - Canada
MH  - Criminals/*psychology
MH  - Empirical Research
MH  - Humans
MH  - *Judicial Role
MH  - *Mental Disorders/therapy
MH  - *Problem Solving
MH  - Program Evaluation
MH  - Substance-Related Disorders
EDAT- 2010/07/29 06:00
MHDA- 2011/01/19 06:00
CRDT- 2010/07/29 06:00
PHST- 2010/07/29 06:00 [entrez]
PHST- 2010/07/29 06:00 [pubmed]
PHST- 2011/01/19 06:00 [medline]
AID - S0160-2527(10)00054-3 [pii]
AID - 10.1016/j.ijlp.2010.06.008 [doi]
PST - ppublish
SO  - Int J Law Psychiatry. 2010 Sep-Oct;33(4):258-64. doi: 10.1016/j.ijlp.2010.06.008.


PMID- 20663165
OWN - NLM
STAT- MEDLINE
DCOM- 20100929
LR  - 20211020
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 11
DP  - 2010 Jul 21
TI  - Heterogeneity prevails: the state of clinical trial data management in Europe -
      results of a survey of ECRIN centres.
PG  - 79
LID - 10.1186/1745-6215-11-79 [doi]
AB  - BACKGROUND: The use of Clinical Data Management Systems (CDMS) has become
      essential in clinical trials to handle the increasing amount of data that must be
      collected and analyzed. With a CDMS trial data are captured at investigator sites
      with "electronic Case Report Forms". Although more and more of these electronic
      data management systems are used in academic research centres an overview of CDMS
      products and of available data management and quality management resources for
      academic clinical trials in Europe is missing. METHODS: The ECRIN (European
      Clinical Research Infrastructure Network) data management working group conducted
      a two-part standardized survey on data management, software tools, and quality
      management for clinical trials. The questionnaires were answered by nearly 80
      centres/units (with an overall response rate of 47% and 43%) from 12 European
      countries and EORTC. RESULTS: Our survey shows that about 90% of centres have a
      CDMS in routine use. Of these CDMS nearly 50% are commercial systems; Open Source
      solutions don't play a major role. In general, solutions used for clinical data
      management are very heterogeneous: 20 different commercial CDMS products (7 Open 
      Source solutions) in addition to 17/18 proprietary systems are in use. The most
      widely employed CDMS products are MACRO and Capture System, followed by solutions
      that are used in at least 3 centres: eResearch Network, CleanWeb, GCP Base and
      SAS. Although quality management systems for data management are in place in most
      centres/units, there exist some deficits in the area of system validation.
      CONCLUSIONS: Because the considerable heterogeneity of data management software
      solutions may be a hindrance to cooperation based on trial data exchange,
      standards like CDISC (Clinical Data Interchange Standard Consortium) should be
      implemented more widely. In a heterogeneous environment the use of data standards
      can simplify data exchange, increase the quality of data and prepare centres for 
      new developments (e.g. the use of EHR for clinical research). Because data
      management and the use of electronic data capture systems in clinical trials are 
      characterized by the impact of regulations and guidelines, ethical concerns are
      discussed. In this context quality management becomes an important part of
      compliant data management. To address these issues ECRIN will establish certified
      data centres to support electronic data management and associated compliance
      needs of clinical trial centres in Europe.
FAU - Kuchinke, Wolfgang
AU  - Kuchinke W
AD  - Coordination Centre for Clinical Trials, Heinrich-Heine University Duesseldorf,
      Duesseldorf, Germany. kuchinke@med.uni-duesseldorf.de
FAU - Ohmann, Christian
AU  - Ohmann C
FAU - Yang, Qin
AU  - Yang Q
FAU - Salas, Nader
AU  - Salas N
FAU - Lauritsen, Jens
AU  - Lauritsen J
FAU - Gueyffier, Francois
AU  - Gueyffier F
FAU - Leizorovicz, Alan
AU  - Leizorovicz A
FAU - Schade-Brittinger, Carmen
AU  - Schade-Brittinger C
FAU - Wittenberg, Michael
AU  - Wittenberg M
FAU - Voko, Zoltan
AU  - Voko Z
FAU - Gaynor, Siobhan
AU  - Gaynor S
FAU - Cooney, Margaret
AU  - Cooney M
FAU - Doran, Peter
AU  - Doran P
FAU - Maggioni, Aldo
AU  - Maggioni A
FAU - Lorimer, Andrea
AU  - Lorimer A
FAU - Torres, Ferran
AU  - Torres F
FAU - McPherson, Gladys
AU  - McPherson G
FAU - Charwill, Jim
AU  - Charwill J
FAU - Hellstrom, Mats
AU  - Hellstrom M
FAU - Lejeune, Stephane
AU  - Lejeune S
LA  - eng
GR  - HSRU1/CSO_/Chief Scientist Office/United Kingdom
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20100721
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
SB  - IM
MH  - Biomedical Research/organization & administration
MH  - Clinical Trials as Topic/*statistics & numerical data
MH  - *Computer Systems
MH  - *Data Collection/methods
MH  - *Databases, Factual
MH  - Europe
MH  - Humans
MH  - Medical Informatics/*organization & administration
MH  - Surveys and Questionnaires
PMC - PMC2918594
EDAT- 2010/07/29 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/07/29 06:00
PHST- 2009/12/21 00:00 [received]
PHST- 2010/07/21 00:00 [accepted]
PHST- 2010/07/29 06:00 [entrez]
PHST- 2010/07/29 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - 1745-6215-11-79 [pii]
AID - 10.1186/1745-6215-11-79 [doi]
PST - epublish
SO  - Trials. 2010 Jul 21;11:79. doi: 10.1186/1745-6215-11-79.


PMID- 20663001
OWN - NLM
STAT- MEDLINE
DCOM- 20110502
LR  - 20101223
IS  - 1365-2753 (Electronic)
IS  - 1356-1294 (Linking)
VI  - 16
IP  - 6
DP  - 2010 Dec
TI  - The improper use of research placebos.
PG  - 1041-4
LID - 10.1111/j.1365-2753.2009.01246.x [doi]
AB  - RATIONALE: Reasons given for the routine use of placebos in Phase III clinical
      research are not convincing. Ethically inadequate strategies such as using
      placebos and recruiting the mentally incompetent for non-therapeutic research are
      allegedly permissible because research is purportedly aimed at benefiting the
      common weal. METHOD AND RESULTS: A review of current literature concludes that
      placebos are not equivalent to inactive substances, as has been amply shown in
      clinical use; in research settings they may actually be harmful, for patients
      recruited as research subjects often develop expectations that are all the more
      frustrated if they receive a control substance that is not therapeutic but may
      show unexpected side effects. Supposedly inert control substances have met with
      strong opposition, for patients are placed at risk of becoming therapeutic
      orphans when their current medication is withdrawn and they have a 50% chance of 
      being randomized to the inactive control arm. Using placebos, it is claimed,
      increase the internal validity of a study, but this concern appears misplaced
      when scant attention to external validity is given. CONCLUSIONS: Although
      rejected and disregarded by many investigators, it is an accepted practice that
      control groups should receive the best treatment in existence, not what is
      locally available nor a placebo. Inactive comparators should only be used when no
      effective medications exists for the disease under scrutiny. Bioethics should be 
      wary of the tenuous justifications presented, as researchers rarely resort to
      placebos in their own sponsor countries, while actively endorsing them in Third
      World nations where most of their trials are being located.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Kottow, Miguel
AU  - Kottow M
AD  - Universidad de Chile, Universidad Diego Portales, Santiago, Chile.
      mkottow@gmail.com
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Eval Clin Pract
JT  - Journal of evaluation in clinical practice
JID - 9609066
RN  - 0 (Placebos)
SB  - IM
MH  - Clinical Trials, Phase III as Topic/*ethics/methods
MH  - Evidence-Based Medicine
MH  - Humans
MH  - Placebos/*therapeutic use
MH  - *Research Design
MH  - Review Literature as Topic
EDAT- 2010/07/29 06:00
MHDA- 2011/05/03 06:00
CRDT- 2010/07/29 06:00
PHST- 2010/07/29 06:00 [entrez]
PHST- 2010/07/29 06:00 [pubmed]
PHST- 2011/05/03 06:00 [medline]
AID - JEP1246 [pii]
AID - 10.1111/j.1365-2753.2009.01246.x [doi]
PST - ppublish
SO  - J Eval Clin Pract. 2010 Dec;16(6):1041-4. doi: 10.1111/j.1365-2753.2009.01246.x.


PMID- 20662622
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20100819
IS  - 1469-9567 (Electronic)
IS  - 1356-1820 (Linking)
VI  - 24
IP  - 5
DP  - 2010 Sep
TI  - Undressing the Emperor? On the ethical dilemmas of hierarchical knowledge.
PG  - 579-86
LID - 10.3109/13561820903520393 [doi]
AB  - The title refers to Hans Christian Andersen's fairytale "The Emperor's New
      Clothes". It indicates how hierarchies of power dominate what we see and how we
      act - in short, our ethical interaction. The author considers collaboration to be
      a prerequisite for improving quality in the arenas of health and social work, in 
      persons as well as systems. She argues that a radical change in the direction of 
      understanding knowledge and competence as co-creational is required. This again
      calls for a redefinition not only of the role of professions, of what it takes to
      be a professional, but also of the role of the user. Consequently, the author's
      approach challenges the institutional framework of health and social work, as
      well as the content and methodology of teaching.
FAU - Skaerbaek, Eva
AU  - Skaerbaek E
AD  - Faculty of Health and Social Studies in Fredrikstad, Ostfold University College, 
      1757 Halden, Norway. eva.skaerbaek@hiof.no
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Interprof Care
JT  - Journal of interprofessional care
JID - 9205811
SB  - IM
MH  - *Cooperative Behavior
MH  - *Health Knowledge, Attitudes, Practice
MH  - Health Personnel/education/*ethics
MH  - Humans
MH  - *Interprofessional Relations
MH  - Social Work/education/*ethics
EDAT- 2010/07/29 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/07/29 06:00
PHST- 2010/07/29 06:00 [entrez]
PHST- 2010/07/29 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.3109/13561820903520393 [doi]
PST - ppublish
SO  - J Interprof Care. 2010 Sep;24(5):579-86. doi: 10.3109/13561820903520393.


PMID- 20661593
OWN - NLM
STAT- MEDLINE
DCOM- 20110202
LR  - 20211020
IS  - 1432-2129 (Electronic)
IS  - 0932-433X (Linking)
VI  - 24
IP  - 4
DP  - 2010 Aug
TI  - [Sedation in palliative medicine: Guidelines for the use of sedation in
      palliative care : European Association for Palliative Care (EAPC)].
PG  - 342-54
LID - 10.1007/s00482-010-0948-5 [doi]
AB  - The European Association for Palliative Care (EAPC) considers sedation to be an
      important and necessary therapy option in the care of selected palliative care
      patients with otherwise refractory distress. Prudent application of this approach
      requires due caution and good clinical practice. Inattention to potential risks
      and problematic practices can lead to harmful and unethical practice which may
      undermine the credibility and reputation of the responsible clinicians and
      institutions as well as the discipline of palliative medicine more generally.
      Procedural guidelines are helpful to educate medical providers, set standards for
      best practice, promote optimal care and convey the important message to staff,
      patients and families that palliative sedation is an accepted, ethical practice
      when used in appropriate situations. EAPC aims to facilitate the development of
      such guidelines by presenting a 10-point framework that is based on the
      pre-existing guidelines and literature and extensive peer review.
FAU - Alt-Epping, B
AU  - Alt-Epping B
AD  - Abteilung Palliativmedizin, Universitatsmedizin Gottingen, Robert-Koch-Str. 40,
      37075, Gottingen, Deutschland. bernd.alt-epping@med.uni-goettingen.de
FAU - Sitte, T
AU  - Sitte T
FAU - Nauck, F
AU  - Nauck F
FAU - Radbruch, L
AU  - Radbruch L
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Sedierung in der Palliativmedizin*: Leitlinie fur den Einsatz sedierender
      Massnahmen in der Palliativversorgung : European Association for Palliative Care 
      (EAPC).
PL  - Germany
TA  - Schmerz
JT  - Schmerz (Berlin, Germany)
JID - 8906258
RN  - 0 (Antipsychotic Agents)
RN  - 620X0222FQ (Flunitrazepam)
RN  - O26FZP769L (Lorazepam)
SB  - IM
MH  - Antipsychotic Agents/adverse effects/therapeutic use
MH  - Conscious Sedation/adverse effects/*methods/standards
MH  - Europe
MH  - Flunitrazepam/adverse effects/therapeutic use
MH  - Health Services Misuse
MH  - Humans
MH  - Lorazepam/adverse effects/therapeutic use
MH  - Palliative Care/*methods/standards
MH  - Practice Guidelines as Topic
MH  - Risk Assessment
MH  - Societies, Medical
EDAT- 2010/07/28 06:00
MHDA- 2011/02/03 06:00
CRDT- 2010/07/28 06:00
PHST- 2010/07/28 06:00 [entrez]
PHST- 2010/07/28 06:00 [pubmed]
PHST- 2011/02/03 06:00 [medline]
AID - 10.1007/s00482-010-0948-5 [doi]
PST - ppublish
SO  - Schmerz. 2010 Aug;24(4):342-54. doi: 10.1007/s00482-010-0948-5.


PMID- 20661262
OWN - NLM
STAT- MEDLINE
DCOM- 20100820
LR  - 20211020
IS  - 1546-1726 (Electronic)
IS  - 1097-6256 (Linking)
VI  - 13
IP  - 8
DP  - 2010 Aug
TI  - Extending trust. A report of a potential therapy for some of the social behavior 
      patterns associated with autism highlights the need for a societal dialog to
      discuss the ethical issues raised by these treatments.
PG  - 905
LID - 10.1038/nn0810-905 [doi]
LA  - eng
PT  - Editorial
PL  - United States
TA  - Nat Neurosci
JT  - Nature neuroscience
JID - 9809671
RN  - 50-56-6 (Oxytocin)
SB  - IM
MH  - Child
MH  - Child Development Disorders, Pervasive/*drug therapy
MH  - *Ethics, Medical
MH  - Humans
MH  - Interpersonal Relations
MH  - Oxytocin/*therapeutic use
MH  - Personality/*drug effects
MH  - Trust/psychology
EDAT- 2010/07/28 06:00
MHDA- 2010/08/21 06:00
CRDT- 2010/07/28 06:00
PHST- 2010/07/28 06:00 [entrez]
PHST- 2010/07/28 06:00 [pubmed]
PHST- 2010/08/21 06:00 [medline]
AID - nn0810-905 [pii]
AID - 10.1038/nn0810-905 [doi]
PST - ppublish
SO  - Nat Neurosci. 2010 Aug;13(8):905. doi: 10.1038/nn0810-905.


PMID- 20661199
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20111024
IS  - 1827-1596 (Electronic)
IS  - 0375-9393 (Linking)
VI  - 76
IP  - 8
DP  - 2010 Aug
TI  - Comparison of the effect of LMA and ETT on ventilation and intragastric pressure 
      in pediatric laparoscopic procedures.
PG  - 592-9
AB  - BACKGROUND: The aim of our study was to compare classic laryngeal mask airway
      (LMA-C) with the endotracheal tube (ETT) in pediatric laparoscopic surgery to
      evaluate the intragastric pressures (IGP) using intragastric pressure monitoring.
      We also sought to investigate the related influence on respiratory parameters.
      METHODS: The Ethics Committee of the Health Institution approved the study
      protocol. A total of 40 patients, ASA I-II, three and a half months to 12 years
      old were included in this randomized study. Two study groups were formed: the ETT
      group and the LMA-C group. A nasogastric tube was inserted following induction to
      evacuate any intragastric gas and fluid before application of either LMA-C or
      ETT. The change in IGP was measured with a transducer, which was attached to the 
      nasogastric tube. IGP, peak airway pressures (PAP), SPO2 and ETCO2 were recorded.
      Repeated ANOVA measures were used to evaluate the change in IGP, PAP, SPO2 and
      ETCO2 times in both groups. RESULTS: The change in IGP was not significant among 
      the groups except at 15 and 30 minutes (P<0.05). The changes in PAP, SPO2, and
      ETCO2 levels were not significant. CONCLUSION: The perioperative intragastric
      pressure evaluation failed to show any significant change in intragastric
      pressures and ventilation parameters due to the application of LMA-C in this
      study. We advocate LMA-C application as a feasible anesthetic device in pediatric
      laparoscopic surgery.
FAU - Ozdamar, D
AU  - Ozdamar D
AD  - Department of Anesthesiology and Reanimation, Kocaeli University School of
      Medicine, Kocaeli, Turkey. dilekozdamar@gmail.com
FAU - Guvenc, B H
AU  - Guvenc BH
FAU - Toker, K
AU  - Toker K
FAU - Solak, M
AU  - Solak M
FAU - Ekingen, G
AU  - Ekingen G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20100618
PL  - Italy
TA  - Minerva Anestesiol
JT  - Minerva anestesiologica
JID - 0375272
SB  - IM
CIN - Minerva Anestesiol. 2010 Aug;76(8):575-6. PMID: 20661196
MH  - Child
MH  - Child, Preschool
MH  - Hernia, Inguinal/*surgery
MH  - Humans
MH  - Intubation, Intratracheal/*instrumentation
MH  - Laparoscopy/*methods
MH  - *Laryngeal Masks
MH  - Pressure
MH  - Prospective Studies
MH  - Pulmonary Ventilation/physiology
MH  - Stomach/physiology
EDAT- 2010/07/28 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/07/28 06:00
PHST- 2010/07/28 06:00 [entrez]
PHST- 2010/07/28 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - R02105683 [pii]
PST - ppublish
SO  - Minerva Anestesiol. 2010 Aug;76(8):592-9. Epub 2010 Jun 18.


PMID- 20661197
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20110107
IS  - 1827-1596 (Electronic)
IS  - 0375-9393 (Linking)
VI  - 76
IP  - 8
DP  - 2010 Aug
TI  - Tracheal intubation using the mobile C-MAC video laryngoscope or direct
      laryngoscopy for patients with a simulated difficult airway.
PG  - 577-83
AB  - BACKGROUND: Several studies have shown that video laryngoscopy enhances the
      laryngeal view in patients with apparently normal and anticipated difficult
      airways. The utility of the novel, portable, battery-powered C-MAC video
      laryngoscope is unproven, but its design makes it potentially useful for
      emergency situations. We hypothesized that, in patients with a simulated
      difficult airway created by means of a rigid cervical immobilization collar, the 
      rate of glottic views considered "failed" under direct laryngoscopy could be
      significantly reduced with the C-MAC video laryngoscope. METHODS: Following power
      analysis and ethical approval, 43 adults undergoing surgery under general
      anesthesia were studied. First, direct laryngoscopy was performed with the naked 
      eye with and without applying external laryngeal pressure (BURP maneuver). The
      best-obtained view was graded by the laryngoscopist without looking at the video 
      monitor. A second anesthesiologist, who was blinded to the laryngeal view
      obtained under direct laryngoscopy, graded the laryngeal view on the video
      monitor. A difficult airway was then created and the laryngoscopy sequence
      repeated. Endotracheal intubation was then attempted under video-aided
      visualization. RESULTS: In patients with a normal airway, the glottic view was
      considered as "good" in the vast majority of patients (40-43/43; 93-100%)
      regardless of the laryngoscopy technique used. When a difficult airway was
      created, the glottic view was graded as "failed" in 30/43 (70%) and 16/43 (37%)
      of patients under direct laryngoscopy without and with the BURP maneuver,
      respectively (P=0.0047). Using video laryngoscopy, significantly fewer
      laryngoscopic views were graded as "failed" without (14%, P<0.0001) and with the 
      BURP maneuver (5%, P=0.0003) compared to direct laryngoscopy. Endotracheal tube
      placement was successful in 88% of patients with a difficult airway. CONCLUSION: 
      The C-MAC video laryngoscope effectively enhanced the laryngeal view in patients 
      with limited inter-incisor distance and eliminated cervical spine clearance.
      However, endotracheal tube placement failed in 5/43 patients despite a mostly
      good laryngeal view.
FAU - Byhahn, C
AU  - Byhahn C
AD  - Clinic of Anesthesiology, Intensive Care Medicine and Pain Therapy, J.W.
      Goethe-University Hospital Frankfurt, Frankfurt, Germany.
      c.byhahn@em.uni-frankfurt.de
FAU - Iber, T
AU  - Iber T
FAU - Zacharowski, K
AU  - Zacharowski K
FAU - Weber, C F
AU  - Weber CF
FAU - Ruesseler, M
AU  - Ruesseler M
FAU - Schalk, R
AU  - Schalk R
FAU - Meininger, D
AU  - Meininger D
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Minerva Anestesiol
JT  - Minerva anestesiologica
JID - 0375272
SB  - IM
CIN - Minerva Anestesiol. 2010 Aug;76(8):569-71. PMID: 20661194
CIN - Minerva Anestesiol. 2010 Dec;76(12):1098-9; author reply 1100. PMID: 21102397
MH  - Adult
MH  - Equipment Design
MH  - Female
MH  - Humans
MH  - *Intubation, Intratracheal/instrumentation/methods
MH  - *Laryngoscopes
MH  - Laryngoscopy/*methods
MH  - Male
MH  - Video Recording
EDAT- 2010/07/28 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/07/28 06:00
PHST- 2010/07/28 06:00 [entrez]
PHST- 2010/07/28 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - R02105852 [pii]
PST - ppublish
SO  - Minerva Anestesiol. 2010 Aug;76(8):577-83.


PMID- 20660368
OWN - NLM
STAT- MEDLINE
DCOM- 20110317
LR  - 20191210
IS  - 1049-7323 (Print)
IS  - 1049-7323 (Linking)
VI  - 20
IP  - 12
DP  - 2010 Dec
TI  - A critique of current practice: ten foundational guidelines for
      autoethnographers.
PG  - 1599-610
LID - 10.1177/1049732310376076 [doi]
AB  - Any research is potentially compromised when researchers address ethical issues
      retrospectively rather than by anticipating these issues. In this regard,
      creative analytical practices (CAP) autoethnography has endemic problems. In Part
      1 of this article, I detail a case study of an autoethnography in which journal
      reviewers insisted that an author gain retrospective informed consent from the 23
      persons documented in an autoethnography. Yet the journal reviewers' insistence
      failed to go one step further-acknowledging that a conflict of interest develops 
      when gaining consent retrospectively. In Part 2, I contrast three leading
      autoethnographers' justifications for not gaining informed consent with the
      Position Statement on Qualitative Research developed by successive Congresses of 
      Qualitative Inquiry. In Part 3, I identify resources available for
      autoethnographers, including ethical issues present when researchers use
      autoethnography to heal themselves, violating the internal confidentiality of
      relational others. In Part 4, I question if autoethnography is research and, like
      journalism, exempt from formal ethics review. Throughout the article, 10
      foundational ethical considerations for autoethnographers are developed, taking
      autoethnographers beyond procedural ethics and providing tools for their ethics
      in practice.
FAU - Tolich, Martin
AU  - Tolich M
AD  - University of Otago, Dunedin, New Zealand. martin.tolich@otago.ac.nz
LA  - eng
PT  - Journal Article
DEP - 20100721
PL  - United States
TA  - Qual Health Res
JT  - Qualitative health research
JID - 9202144
MH  - Anthropology, Cultural/*ethics
MH  - *Autobiographies as Topic
MH  - Conflict of Interest
MH  - Disclosure
MH  - *Ethics, Research
MH  - Guidelines as Topic
MH  - Humans
MH  - Informed Consent/*ethics
MH  - *Qualitative Research
EDAT- 2010/07/28 06:00
MHDA- 2011/03/18 06:00
CRDT- 2010/07/28 06:00
PHST- 2010/07/28 06:00 [entrez]
PHST- 2010/07/28 06:00 [pubmed]
PHST- 2011/03/18 06:00 [medline]
AID - 1049732310376076 [pii]
AID - 10.1177/1049732310376076 [doi]
PST - ppublish
SO  - Qual Health Res. 2010 Dec;20(12):1599-610. doi: 10.1177/1049732310376076. Epub
      2010 Jul 21.


PMID- 20660044
OWN - NLM
STAT- MEDLINE
DCOM- 20101115
LR  - 20131121
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 95
IP  - 10
DP  - 2010 Oct
TI  - Rest-activity disturbances in children with septo-optic dysplasia characterized
      by actigraphy and 24-hour plasma melatonin profiles.
PG  - E198-203
LID - 10.1210/jc.2010-0027 [doi]
AB  - INTRODUCTION: A trial of melatonin treatment in children with septo-optic
      dysplasia (SOD) and sleep disruption is accepted clinical practice in many
      centers. However, no objective measurements of sleep/activity patterns with 24-h 
      melatonin profiles have been published for these individuals, and the
      pathophysiological basis underlying sleep disorders in SOD remains largely
      unknown. METHODS: We studied six children with rest-activity disturbances and
      SOD. All wore an Actiwatch-Mini (a noninvasive method of detecting and recording 
      movement intensity) for 2 wk and were admitted to hospital for a 24-h period
      during which hourly measurements of serum melatonin were taken. Sleep data were
      analyzed in conjunction with a detailed sleep diary. Ethical approval was
      obtained for these studies. RESULTS: Two children produced virtually no melatonin
      throughout the 24-h period of measurement and had fragmented sleep patterns with 
      no evidence of a non-24-h sleep-wake disorder or delayed sleep-phase disorder.
      One child had a normal melatonin profile despite actigraphy showing an arrhythmic
      sleep pattern. The remaining three children had fragmented sleep, with two having
      normal melatonin profiles and one having a modest increase in daytime melatonin
      concentrations, making the timing of dim-light melatonin onset difficult to
      discern. CONCLUSIONS: There is considerable variation in timing and amount of
      melatonin secretion in these children. Surprisingly, none of the children had
      either actigraphic or melatonin profile evidence of a non-24-h sleep-wake
      disorder or delayed sleep-phase disorder. Understanding the heterogeneous nature 
      of underlying sleep disorders in this group of children is important and has
      implications for their management.
FAU - Webb, E A
AU  - Webb EA
AD  - University College London (UCL) Institute of Child Health, Great Ormond Street
      Children's Hospital, London, United Kingdom. e.webb@ich.ucl.ac.uk
FAU - O'Reilly, M A
AU  - O'Reilly MA
FAU - Orgill, J
AU  - Orgill J
FAU - Dale, N
AU  - Dale N
FAU - Salt, A
AU  - Salt A
FAU - Gringras, P
AU  - Gringras P
FAU - Dattani, M T
AU  - Dattani MT
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
DEP - 20100721
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - JL5DK93RCL (Melatonin)
SB  - IM
MH  - *Actigraphy/methods
MH  - Activity Cycles/*physiology
MH  - Child
MH  - Child, Preschool
MH  - Chronobiology Disorders/blood/complications/*diagnosis/physiopathology
MH  - Circadian Rhythm
MH  - Diagnostic Techniques, Endocrine
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Melatonin/analysis/*blood/metabolism
MH  - Metabolome
MH  - Rest/physiology
MH  - Septo-Optic Dysplasia/blood/complications/*diagnosis/physiopathology
EDAT- 2010/07/28 06:00
MHDA- 2010/11/16 06:00
CRDT- 2010/07/28 06:00
PHST- 2010/07/28 06:00 [entrez]
PHST- 2010/07/28 06:00 [pubmed]
PHST- 2010/11/16 06:00 [medline]
AID - jc.2010-0027 [pii]
AID - 10.1210/jc.2010-0027 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2010 Oct;95(10):E198-203. doi: 10.1210/jc.2010-0027.
      Epub 2010 Jul 21.


PMID- 20659986
OWN - NLM
STAT- MEDLINE
DCOM- 20100811
LR  - 20181023
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 341
DP  - 2010 Jul 21
TI  - How to think like an ethicist. Think like a cop.
PG  - c3702
LID - 10.1136/bmj.c3702 [doi]
LID - bmj.c3702 [pii]
FAU - Koch, Tom
AU  - Koch T
LA  - eng
PT  - Comment
PT  - Letter
DEP - 20100721
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
SB  - IM
CON - BMJ. 2010;340:c3256. PMID: 20573764
MH  - *Bioethical Issues
MH  - *Ethics, Medical
MH  - Humans
EDAT- 2010/07/28 06:00
MHDA- 2010/08/12 06:00
CRDT- 2010/07/28 06:00
PHST- 2010/07/28 06:00 [entrez]
PHST- 2010/07/28 06:00 [pubmed]
PHST- 2010/08/12 06:00 [medline]
AID - 10.1136/bmj.c3702 [doi]
PST - epublish
SO  - BMJ. 2010 Jul 21;341:c3702. doi: 10.1136/bmj.c3702.


PMID- 20659705
OWN - NLM
STAT- MEDLINE
DCOM- 20110202
LR  - 20100727
IS  - 1673-8527 (Print)
IS  - 1673-8527 (Linking)
VI  - 37
IP  - 7
DP  - 2010 Jul
TI  - Induced pluripotent stem cells (iPSCs)--a new era of reprogramming.
PG  - 415-21
LID - 10.1016/S1673-8527(09)60060-6 [doi]
AB  - Embryonic stem cells (ESCs) derived from the early embryos possess two important 
      characteristics: self-renewal and pluripotency, which make ESCs ideal seed cells 
      that could be potentially utilized for curing a number of degenerative and
      genetic diseases clinically. However, ethical concerns and immune rejection after
      cell transplantation limited the clinical application of ESCs. Fortunately, the
      recent advances in induced pluripotent stem cell (iPSC) research have clearly
      shown that differentiated somatic cells from various species could be
      reprogrammed into pluripotent state by ectopically expressing a combination of
      several transcription factors, which are highly enriched in ESCs. This
      ground-breaking achievement could circumvent most of the limitations that ESCs
      faced. However, it remains challenging if the iPS cell lines, especially the
      human iPSCs lines, available are fully pluripotent. Therefore, it is prerequisite
      to establish a molecular standard to distinguish the better quality iPSCs from
      the inferior ones.
CI  - Copyright 2010 Institute of Genetics and Developmental Biology and the Genetics
      Society of China. Published by Elsevier Ltd. All rights reserved.
FAU - Kang, Lan
AU  - Kang L
AD  - National Institute of Biological Sciences, NIBS, Beijing 102206, China.
FAU - Kou, Zhaohui
AU  - Kou Z
FAU - Zhang, Yu
AU  - Zhang Y
FAU - Gao, Shaorong
AU  - Gao S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - J Genet Genomics
JT  - Journal of genetics and genomics = Yi chuan xue bao
JID - 101304616
SB  - IM
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*physiology
MH  - Pluripotent Stem Cells/*transplantation
EDAT- 2010/07/28 06:00
MHDA- 2011/02/03 06:00
CRDT- 2010/07/28 06:00
PHST- 2010/03/22 00:00 [received]
PHST- 2010/04/09 00:00 [revised]
PHST- 2010/04/20 00:00 [accepted]
PHST- 2010/07/28 06:00 [entrez]
PHST- 2010/07/28 06:00 [pubmed]
PHST- 2011/02/03 06:00 [medline]
AID - S1673-8527(09)60060-6 [pii]
AID - 10.1016/S1673-8527(09)60060-6 [doi]
PST - ppublish
SO  - J Genet Genomics. 2010 Jul;37(7):415-21. doi: 10.1016/S1673-8527(09)60060-6.


PMID- 20659058
OWN - NLM
STAT- MEDLINE
DCOM- 20110121
LR  - 20211020
IS  - 1360-0443 (Electronic)
IS  - 0965-2140 (Linking)
VI  - 105
IP  - 6
DP  - 2010 Jun
TI  - 'To prove this is the industry's best hope': big tobacco's support of research on
      the genetics of nicotine addiction.
PG  - 974-83
LID - 10.1111/j.1360-0443.2010.02940.x [doi]
AB  - BACKGROUND: New molecular techniques focus a genetic lens upon nicotine
      addiction. Given the medical and economic costs associated with smoking,
      innovative approaches to smoking cessation and prevention must be pursued; but
      can sound research be manipulated by the tobacco industry? METHODOLOGY: The
      chronological narrative of this paper was created using iterative reviews of
      primary sources (the Legacy Tobacco Documents), supplemented with secondary
      literature to provide a broader context. The empirical data inform an ethics and 
      policy analysis of tobacco industry-funded research. FINDINGS: The search for a
      genetic basis for smoking is consistent with industry's decades-long plan to
      deflect responsibility away from the tobacco companies and onto individuals'
      genetic constitutions. Internal documents reveal long-standing support for
      genetic research as a strategy to relieve the tobacco industry of its legal
      responsibility for tobacco-related disease. CONCLUSIONS: Industry may turn the
      findings of genetics to its own ends, changing strategy from creating a 'safe'
      cigarette to defining a 'safe' smoker.
FAU - Gundle, Kenneth R
AU  - Gundle KR
AD  - Harvard Medical School, Boston, MA, USA.
FAU - Dingel, Molly J
AU  - Dingel MJ
FAU - Koenig, Barbara A
AU  - Koenig BA
LA  - eng
GR  - R01 DA014577-05/DA/NIDA NIH HHS/United States
GR  - R01 DA014577-04/DA/NIDA NIH HHS/United States
GR  - R01 DA014577/DA/NIDA NIH HHS/United States
GR  - R01 DA014577-03/DA/NIDA NIH HHS/United States
GR  - R01 DA14577/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - Addiction
JT  - Addiction (Abingdon, England)
JID - 9304118
SB  - IM
MH  - *Conflict of Interest
MH  - Deception
MH  - *Documentation
MH  - Genetic Predisposition to Disease
MH  - Genetic Research/economics
MH  - Humans
MH  - Lung Neoplasms/etiology
MH  - Male
MH  - Public Health
MH  - Research Support as Topic
MH  - Smoking/adverse effects/*genetics/psychology
MH  - *Tobacco Industry/ethics/legislation & jurisprudence
MH  - Tobacco Use Disorder/*genetics/psychology
PMC - PMC2911634
MID - NIHMS209325
EDAT- 2010/07/28 06:00
MHDA- 2011/01/22 06:00
CRDT- 2010/07/28 06:00
PHST- 2010/07/28 06:00 [entrez]
PHST- 2010/07/28 06:00 [pubmed]
PHST- 2011/01/22 06:00 [medline]
AID - ADD2940 [pii]
AID - 10.1111/j.1360-0443.2010.02940.x [doi]
PST - ppublish
SO  - Addiction. 2010 Jun;105(6):974-83. doi: 10.1111/j.1360-0443.2010.02940.x.


PMID- 20658948
OWN - NLM
STAT- MEDLINE
DCOM- 20110218
LR  - 20161018
IS  - 1437-4331 (Electronic)
IS  - 1434-6621 (Linking)
VI  - 48
IP  - 10
DP  - 2010 Oct
TI  - Development and description of GETT: a genetic testing evidence tracking tool.
PG  - 1397-407
LID - 10.1515/CCLM.2010.291 [doi]
AB  - BACKGROUND: The completion of the Human Genome Project has increased the pace of 
      discovery of genetic markers for disease. Despite tremendous efforts in
      fundamental research, clinical applications still lag behind expectations, partly
      due to the lack of effective tools to systematically search for and summarize
      published data relative to the clinical assessment of new diagnostic molecular
      tests. METHODS: Through a collaborative process using published tools and an
      expert panel, we developed a detailed checklist of the evidence that needs to be 
      collected or produced to evaluate the potential usefulness of a new molecular
      diagnostic test. This tool is called GETT, for Genetic testing Evidence Tracking 
      Tool. RESULTS: GETT allows 1) researchers to summarize the current evidence and
      to identify knowledge gaps for further research and; 2) stakeholders to collect
      data related to a given molecular test and improve their decision-making process.
      GETT comprises 72 clearly defined items/questions, grouped into 10 categories and
      26 sub-themes, including an overview of disease epidemiology and genetics, the
      available diagnostic tools, and their analytical and clinical performances,
      availability of quality control programs, laboratory and clinical best practice
      guidelines, clinical utility, and impact on health care and psycho-social,
      ethical and legal implications. It also includes a summary of the evidence
      available and attempts to prioritise knowledge gaps related to the testing. We
      also compare GETT to other existing frameworks. CONCLUSIONS: This systematic
      evidence-based tracking tool, which is more detailed than existing frameworks and
      provides clear definition for each item, will help streamline collection of the
      available evidence to appraise the potential for clinical application of new
      molecular diagnostic tests and prioritize research to produce the evidence-base
      relative to the clinical implementation of molecular diagnostic tests.
FAU - Rousseau, Francois
AU  - Rousseau F
AD  - Reseau de Medecine Genetique Appliquee du Fonds de Recherche en Sante du Quebec, 
      Quebec, Canada. Francois.rousseau@mac.com
FAU - Lindsay, Carmen
AU  - Lindsay C
FAU - Charland, Marc
AU  - Charland M
FAU - Labelle, Yves
AU  - Labelle Y
FAU - Bergeron, Jean
AU  - Bergeron J
FAU - Blancquaert, Ingeborg
AU  - Blancquaert I
FAU - Delage, Robert
AU  - Delage R
FAU - Gilfix, Brian
AU  - Gilfix B
FAU - Miron, Michel
AU  - Miron M
FAU - Mitchell, Grant A
AU  - Mitchell GA
FAU - Oligny, Luc
AU  - Oligny L
FAU - Pazzagli, Mario
AU  - Pazzagli M
FAU - Mamotte, Cyril
AU  - Mamotte C
FAU - Payne, Deborah
AU  - Payne D
CN  - IFCC Scientific Division Committee on Molecular Diagnostics
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100727
PL  - Germany
TA  - Clin Chem Lab Med
JT  - Clinical chemistry and laboratory medicine
JID - 9806306
SB  - IM
MH  - Clinical Laboratory Techniques
MH  - Decision Support Techniques
MH  - Genetic Testing/*methods
MH  - Humans
MH  - Molecular Diagnostic Techniques/*methods
EDAT- 2010/07/28 06:00
MHDA- 2011/02/22 06:00
CRDT- 2010/07/28 06:00
PHST- 2010/07/28 06:00 [entrez]
PHST- 2010/07/28 06:00 [pubmed]
PHST- 2011/02/22 06:00 [medline]
AID - 10.1515/CCLM.2010.291 [doi]
PST - ppublish
SO  - Clin Chem Lab Med. 2010 Oct;48(10):1397-407. doi: 10.1515/CCLM.2010.291. Epub
      2010 Jul 27.


PMID- 20658847
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20191210
IS  - 1939-1315 (Electronic)
IS  - 0022-3514 (Linking)
VI  - 99
IP  - 2
DP  - 2010 Aug
TI  - Situational similarity and personality predict behavioral consistency.
PG  - 330-43
LID - 10.1037/a0019796 [doi]
AB  - A new method for assessing situations is employed to examine the association
      between situational similarity, personality, and behavioral consistency across
      ecologically representative contexts. On 4 occasions across 4 weeks, 202
      undergraduate participants (105 women, 97 men) wrote descriptions of a situation 
      they had experienced the previous day. In addition, they rated its psychological 
      features using the recently developed Riverside Situational Q-Sort (RSQ) Version 
      2.0 (Wagerman & Funder, 2009) and their behavior using the Riverside Behavioral
      Q-Sort (RBQ) Version 3.0 (Funder, Furr, & Colvin, 2000; Furr, Wagerman, & Funder,
      2010). Independent judges also rated the situations using the RSQ, on the basis
      of the participants' written descriptions. Results indicated (a) participants'
      ratings of their behavior were impressively consistent across the 4 situations;
      (b) the 4 situations experienced by a single participant tended to be described
      more similarly to each other than to situations experienced by different
      participants; (c) situational similarity, especially from the individual's own
      point of view, strongly predicted behavioral consistency; and (d) personality
      characteristics predicted behavioral consistency even after controlling for
      situational similarity. Relatively consistent persons described themselves as
      ethically consistent, conservative, calm and relaxed, and low on neuroticism.
      These results imply that behavioral consistency in daily life stems from multiple
      sources, including situation selection and the distinctive influence of
      personality, and further suggest that tools for situational assessment such as
      the RSQ can have wide utility.
FAU - Sherman, Ryne A
AU  - Sherman RA
AD  - Department of Psychology, University of California, 900 University Avenue,
      Riverside, CA 92521, USA. ryne.sherman@email.ucr.edu
FAU - Nave, Christopher S
AU  - Nave CS
FAU - Funder, David C
AU  - Funder DC
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Pers Soc Psychol
JT  - Journal of personality and social psychology
JID - 0014171
SB  - IM
MH  - Female
MH  - Humans
MH  - Male
MH  - Personality/*physiology
MH  - Personality Assessment/statistics & numerical data
MH  - Predictive Value of Tests
MH  - Q-Sort/statistics & numerical data
MH  - Recognition, Psychology/*physiology
MH  - *Social Behavior
MH  - Students/psychology
EDAT- 2010/07/28 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/07/28 06:00
PHST- 2010/07/28 06:00 [entrez]
PHST- 2010/07/28 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - 2010-14719-009 [pii]
AID - 10.1037/a0019796 [doi]
PST - ppublish
SO  - J Pers Soc Psychol. 2010 Aug;99(2):330-43. doi: 10.1037/a0019796.


PMID- 20658546
OWN - NLM
STAT- MEDLINE
DCOM- 20101029
LR  - 20220321
IS  - 1097-0258 (Electronic)
IS  - 0277-6715 (Linking)
VI  - 29
IP  - 17
DP  - 2010 Jul 30
TI  - Response-adaptive randomization for clinical trials with adjustment for covariate
      imbalance.
PG  - 1761-8
LID - 10.1002/sim.3978 [doi]
AB  - In clinical trials with a small sample size, the characteristics (covariates) of 
      patients assigned to different treatment arms may not be well balanced. This may 
      lead to an inflated type I error rate. This problem can be more severe in trials 
      that use response-adaptive randomization rather than equal randomization because 
      the former may result in smaller sample sizes for some treatment arms. We have
      developed a patient allocation scheme for trials with binary outcomes to adjust
      the covariate imbalance during response-adaptive randomization. We used
      simulation studies to evaluate the performance of the proposed design. The
      proposed design keeps the important advantage of a standard response-adaptive
      design, that is to assign more patients to the better treatment arms, and thus it
      is ethically appealing. On the other hand, the proposed design improves over the 
      standard response-adaptive design by controlling covariate imbalance between
      treatment arms, maintaining the nominal type I error rate, and offering greater
      power.
CI  - Copyright (c) 2010 John Wiley & Sons, Ltd.
FAU - Ning, Jing
AU  - Ning J
AD  - Division of Biostatistics, School of Public Health, The University of Texas,
      Houston, TX 77030, USA. jing.ning@uth.tmc.edu
FAU - Huang, Xuelin
AU  - Huang X
LA  - eng
GR  - P50 CA100632-07/CA/NCI NIH HHS/United States
GR  - P01 CA055164-17/CA/NCI NIH HHS/United States
GR  - 5P01 CA055164/CA/NCI NIH HHS/United States
GR  - P50 CA100632/CA/NCI NIH HHS/United States
GR  - P01 CA108631-05/CA/NCI NIH HHS/United States
GR  - P01 CA108631/CA/NCI NIH HHS/United States
GR  - 1P01 CA108631-01/CA/NCI NIH HHS/United States
GR  - 5P50 CA100632/CA/NCI NIH HHS/United States
GR  - P01 CA055164/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - Stat Med
JT  - Statistics in medicine
JID - 8215016
SB  - IM
MH  - Computer Simulation
MH  - Humans
MH  - Randomized Controlled Trials as Topic/*methods
MH  - *Research Design
MH  - *Sample Size
PMC - PMC2911996
MID - NIHMS202418
EDAT- 2010/07/27 06:00
MHDA- 2010/10/30 06:00
CRDT- 2010/07/27 06:00
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2010/10/30 06:00 [medline]
AID - 10.1002/sim.3978 [doi]
PST - ppublish
SO  - Stat Med. 2010 Jul 30;29(17):1761-8. doi: 10.1002/sim.3978.


PMID- 20658541
OWN - NLM
STAT- MEDLINE
DCOM- 20111013
LR  - 20211020
IS  - 1520-6777 (Electronic)
IS  - 0733-2467 (Linking)
VI  - 30
IP  - 1
DP  - 2011 Jan
TI  - Clinicians' views on the feasibility of surgical randomized trials in
      urogynecology: results of a questionnaire survey.
PG  - 69-74
LID - 10.1002/nau.20943 [doi]
AB  - AIMS: To survey the views of clinicians (urologists and gynecologists) about a
      proposed randomized surgical trial comparing two approaches for the treatment of 
      women with urinary incontinence and vaginal prolapse. METHODS: A questionnaire
      survey nested within a pilot randomized controlled trial of colposuspension
      versus anterior repair plus TVT (CARPET1) for women with incontinence and
      anterior vaginal prolapse. Members of the UK Continence Society, British Society 
      of Urogynaecology, and International Continence Society were sent a single
      electronic mailing of semi-structured questionnaires containing closed and open
      questions and free text response boxes. Free text responses were analyzed using a
      thematic qualitative analysis. RESULTS: One hundred fifty-seven questionnaires
      were returned, from a potential total of 400 from UK and 1,700 international
      respondents. Fifty-eight percent thought the trial ethical, 44% desirable, and
      47% feasible. Thirty-three percent would recruit to the full study, and 22% would
      enroll themselves or their partner. Analysis of free text responses identified
      three themes impacting participation: issues of patient choice and consent;
      clinicians' views of perceived benefit and complications of the two arms; and
      issues about the chosen trial design. CONCLUSIONS: This study highlights the
      difference between collective and individual equipoise and their impact upon
      surgical trials. Clinicians held strong views preventing them from regarding the 
      study favorably. Difficulty with relinquishing control over choice of procedure
      appeared central. These findings support the growing evidence in favor of
      detailed qualitative pilot work for surgical trials. The role of expertise-based 
      randomization deserves further consideration.
CI  - Copyright (c) 2010 Wiley-Liss, Inc.
FAU - Bakali, Evangelia
AU  - Bakali E
AD  - University Hospitals of Leicester NHS Trust, Leicester, UK.
FAU - Pitchforth, Emma
AU  - Pitchforth E
FAU - Tincello, Douglas G
AU  - Tincello DG
FAU - Kenyon, Sara
AU  - Kenyon S
FAU - Slack, Mark
AU  - Slack M
FAU - Toozs-Hobson, Philip
AU  - Toozs-Hobson P
FAU - Mayne, Christopher
AU  - Mayne C
FAU - Jones, David R
AU  - Jones DR
FAU - Taylor, David
AU  - Taylor D
LA  - eng
GR  - 73379/MRC_/Medical Research Council/United Kingdom
GR  - G0500251/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100723
PL  - United States
TA  - Neurourol Urodyn
JT  - Neurourology and urodynamics
JID - 8303326
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Feasibility Studies
MH  - Female
MH  - Gynecology/methods
MH  - Health Care Surveys/methods
MH  - Humans
MH  - International Cooperation
MH  - Male
MH  - Middle Aged
MH  - *Physicians
MH  - *Practice Patterns, Physicians'/statistics & numerical data
MH  - Randomized Controlled Trials as Topic/*statistics & numerical data
MH  - Societies, Medical
MH  - Surveys and Questionnaires/standards
MH  - Treatment Outcome
MH  - Urinary Incontinence/*surgery
MH  - Urology/methods
MH  - Uterine Prolapse/*surgery
EDAT- 2010/07/27 06:00
MHDA- 2011/10/14 06:00
CRDT- 2010/07/27 06:00
PHST- 2010/02/08 00:00 [received]
PHST- 2010/04/08 00:00 [accepted]
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2011/10/14 06:00 [medline]
AID - 10.1002/nau.20943 [doi]
PST - ppublish
SO  - Neurourol Urodyn. 2011 Jan;30(1):69-74. doi: 10.1002/nau.20943. Epub 2010 Jul 23.


PMID- 20658239
OWN - NLM
STAT- MEDLINE
DCOM- 20120702
LR  - 20211020
IS  - 1437-160X (Electronic)
IS  - 0172-8172 (Linking)
VI  - 32
IP  - 1
DP  - 2012 Jan
TI  - Assessment of cardiac and pulmonary function in children with juvenile idiopathic
      arthritis.
PG  - 39-46
LID - 10.1007/s00296-010-1548-5 [doi]
AB  - Juvenile idiopathic arthritis (JIA) is the most common rheumatologic disorder of 
      childhood. It is a group of diseases characterized by chronic synovitis and
      associated with many extra-articular manifestations including cardiac and
      pulmonary involvement. Cardiac involvement as pericarditis, myocarditis and
      valvular disease is common in JIA. There are, however, few descriptions
      concerning systolic and diastolic functions of the left ventricle (LV) and the
      development of lung disease in children with JIA. The study was carried out to
      detect the cardiac and pulmonary involvement and to study the systolic and
      diastolic function of the left ventricle in a group of children with juvenile
      idiopathic arthritis. Forty-five children with JIA without any cardiac or
      pulmonary symptoms and 30 age- and sex-matched controls were included in the
      study. M-mode, two-dimensional and pulsed Doppler echocardiography (ECHO) was
      performed on 36 patients. Tissue Doppler ECHO examination was performed on 24
      patients to assess systolic and diastolic functions of left ventricle. Pulmonary 
      function tests: Forced vital capacity (FVC%), the predicted forced expiratory
      volume in the first second (FEV(1)%) and FEV(1)/FVC ratio and peak expiratory
      flow (PEF), total lung capacity (TLC) and residual volume (RV), carbon monoxide
      diffusing capacity of the lung (DLCO) and DLCO/alveolar volume (VA) were
      evaluated in 32 patients. Informed consent was obtained from all children's
      parents. The study protocol was approved by ethical committee of Faculty of
      Medicine, Assiut University. In this study, children with JIA had higher systolic
      and diastolic blood pressures, resting heart rate, left ventricle systolic size
      and volume (4.35 +/- 0.68 vs. 3.92 +/- 0.28, P value = 0.02). On Doppler and
      tissue Doppler analysis, the JIA group had lower peak early filling velocity (E, 
      m/s), higher peak atrial filling velocity (A, m/s) and prolonged diastolic E and 
      A waves deceleration times and isovolumic relaxation time (IRT) compared to
      control. Regarding pulmonary function tests, children with JIA showed significant
      decrease in FVC, PEF, Pimax, Pemax and DLCO compared to normal controls. This
      decrease was not related to age, height or weight of these patients. There was
      significant inverse correlation between lung function parameters and the
      rheumatoid factor titer, erythrosedimentation rate, disease duration and the
      duration of methotrexate use (P < 0.01). Despite of an asymptomatic
      cardiopulmonary status, significant systolic and diastolic functional
      abnormalities exist in children with JIA. Also, both restrictive and obstructive 
      lung impairments were found.
FAU - Alkady, Eman A M
AU  - Alkady EA
AD  - Faculty of Medicine, Department of Rheumatology & Rehabilitation, Assuit
      University, Assuit, Egypt. eman_alkady@yahoo.com
FAU - Helmy, Hatem A R
AU  - Helmy HA
FAU - Mohamed-Hussein, Aliae A R
AU  - Mohamed-Hussein AA
LA  - eng
PT  - Journal Article
DEP - 20100724
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
RN  - 0 (Antirheumatic Agents)
RN  - YL5FZ2Y5U1 (Methotrexate)
SB  - IM
MH  - Adolescent
MH  - Antirheumatic Agents/therapeutic use
MH  - Arthritis, Juvenile/*complications/drug therapy/*physiopathology
MH  - Blood Pressure/physiology
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Echocardiography, Doppler
MH  - Female
MH  - Forced Expiratory Volume/physiology
MH  - Heart/*physiopathology
MH  - Humans
MH  - Lung/*physiopathology
MH  - Lung Diseases/*epidemiology
MH  - Male
MH  - Methotrexate/therapeutic use
MH  - Respiratory Function Tests
MH  - Risk Factors
MH  - Ventricular Dysfunction, Left/*epidemiology
MH  - Vital Capacity/physiology
EDAT- 2010/07/27 06:00
MHDA- 2012/07/03 06:00
CRDT- 2010/07/27 06:00
PHST- 2010/02/05 00:00 [received]
PHST- 2010/07/11 00:00 [accepted]
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2012/07/03 06:00 [medline]
AID - 10.1007/s00296-010-1548-5 [doi]
PST - ppublish
SO  - Rheumatol Int. 2012 Jan;32(1):39-46. doi: 10.1007/s00296-010-1548-5. Epub 2010
      Jul 24.


PMID- 20658181
OWN - NLM
STAT- MEDLINE
DCOM- 20110301
LR  - 20211020
IS  - 1573-3599 (Electronic)
IS  - 1059-7700 (Linking)
VI  - 19
IP  - 6
DP  - 2010 Dec
TI  - "It's challenging on a personal level"--exploring the 'lived experience' of
      Australian and Canadian prenatal genetic counselors.
PG  - 640-52
LID - 10.1007/s10897-010-9315-z [doi]
AB  - Prenatal genetic counselors work with clients who are at risk of having a child
      with a fetal anomaly, or who have been diagnosed with a fetal anomaly. This can
      raise challenging ethical, moral and legal issues for both clients and
      counselors. Few studies have explored whether this type of work impacts on
      genetic counselors themselves. Interviews were conducted with 15 prenatal genetic
      counselors, five from Toronto, Canada and ten from Melbourne, Australia. A
      qualitative approach was used to allow for an in-depth exploration of the
      experiences of genetic counselors working in the prenatal setting. While
      participants reported that working in a prenatal setting affected them in several
      ways, this paper focuses on one particular unanticipated finding--that of the
      impact experienced by counselors from both countries while working when pregnant.
FAU - Menezes, Melody A
AU  - Menezes MA
AD  - Genetics Education and Health Research, Murdoch Childrens Research Institute,
      Parkville, Victoria, Australia.
FAU - Hodgson, Jan M
AU  - Hodgson JM
FAU - Sahhar, Margaret A
AU  - Sahhar MA
FAU - Aitken, Maryanne
AU  - Aitken M
FAU - Metcalfe, Sylvia A
AU  - Metcalfe SA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100724
PL  - United States
TA  - J Genet Couns
JT  - Journal of genetic counseling
JID - 9206865
SB  - IM
CIN - J Genet Couns. 2012 Feb;21(1):31-4. PMID: 22015630
MH  - Female
MH  - *Genetic Counseling
MH  - Humans
MH  - Ontario
MH  - Pregnancy
MH  - *Prenatal Diagnosis
MH  - Queensland
EDAT- 2010/07/27 06:00
MHDA- 2011/03/02 06:00
CRDT- 2010/07/27 06:00
PHST- 2010/05/04 00:00 [received]
PHST- 2010/07/07 00:00 [accepted]
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2011/03/02 06:00 [medline]
AID - 10.1007/s10897-010-9315-z [doi]
PST - ppublish
SO  - J Genet Couns. 2010 Dec;19(6):640-52. doi: 10.1007/s10897-010-9315-z. Epub 2010
      Jul 24.


PMID- 20658084
OWN - NLM
STAT- MEDLINE
DCOM- 20101101
LR  - 20190911
IS  - 0034-7167 (Print)
IS  - 0034-7167 (Linking)
VI  - 63
IP  - 3
DP  - 2010 May-Jun
TI  - [Legal responsibilities of the nurse in obstetrical nursing].
PG  - 464-9
LID - S0034-71672010000300019 [pii]
AB  - The objective of this literature review is to identify how aspects related to
      legal responsibilities of the obstetrics nurse and the obstetrics nursing
      assistant have been approached in Brazilian publications. After researching the
      following databases for the period of 1980 to 2009; BDENF, CINAHL, LILACS, and
      SciELO, seven articles which dealt with judicial aspects were selected for this
      study. It was clear that none of these focused upon legal responsibilities for
      obstetrical nurses. Error prevention was highlighted among the majority of these 
      publications, as well as civil and ethical responsibilities. However, the
      majority point out administrative sanctions and penal responsibilities. These
      aspects need to be researched in greater depth and reported upon, for they may
      contribute to more qualified formal education for nurses concerning the legal
      implications of their practice.
FAU - Winck, Daniela Ries
AU  - Winck DR
AD  - Programa de Pos-graduacao em Enfermagem, Departamento de Enfermagem, Universidade
      Federal de Santa Catarina, Florianopolis, SC. danirieswinck@gmail.com
FAU - Bruggemann, Odalea Maria
AU  - Bruggemann OM
LA  - por
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Responsabilidade legal do enfermeiro em obstetricia.
PL  - Brazil
TA  - Rev Bras Enferm
JT  - Revista brasileira de enfermagem
JID - 7910105
MH  - *Liability, Legal
MH  - Obstetric Nursing/*legislation & jurisprudence/standards
EDAT- 2010/07/27 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/07/27 06:00
PHST- 2009/10/30 00:00 [received]
PHST- 2010/04/01 00:00 [accepted]
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - S0034-71672010000300019 [pii]
AID - 10.1590/s0034-71672010000300019 [doi]
PST - ppublish
SO  - Rev Bras Enferm. 2010 May-Jun;63(3):464-9. doi: 10.1590/s0034-71672010000300019.


PMID- 20658056
OWN - NLM
STAT- MEDLINE
DCOM- 20110324
LR  - 20191027
IS  - 1516-4446 (Print)
IS  - 1516-4446 (Linking)
VI  - 32
IP  - 2
DP  - 2010 Jun
TI  - [Cannabis and mood].
PG  - 173-80
LID - S1516-44462010000200014 [pii]
AB  - OBJECTIVE: Evaluate the relationship between acute and chronic use of cannabis
      and mood changes. METHOD: Articles were selected by electronic search in PubMed. 
      Chapters in books and reference lists of selected articles were also reviewed. As
      the research did not involve humans, there was no evaluation by a Research Ethics
      Committee. RESULTS: High rates of comorbidity between use/abuse/dependence of
      cannabis and affective disorders in longitudinal studies and in clinical samples 
      were observed. Longitudinal studies indicate that, in long-term, the higher use
      of cannabis is associated with an increased risk of developing bipolar disorder, 
      and probably, major depression in subjects initially without affective disorder, 
      but was not found increased risk of cannabis use among those initially only with 
      mania or depression. Another important observation is that substance abuse in
      bipolar patients may be associated with a number of negative characteristics,
      such as difficulty in recovering the affective symptoms, more hospitalizations,
      poor compliance with treatment, increased risk of suicide, aggression and a poor 
      response to lithium. Psychosocial and pharmacological treatments are indicated
      for the management of comorbidity between cannabis and affective disorders.
      CONCLUSION: The relationship between cannabis use and mood changes are observed
      both in the epidemiological research and in the clinical settings.
FAU - Sanches, Rafael Faria
AU  - Sanches RF
AD  - Departamento de Neurociencias e Ciencias do Comportamento, Faculdade de Medicina 
      de Ribeirao Preto, Universidade de Sao Paulo, Av. dos Bandeirantes 3.900,
      Ribeirao Preto, SP, Brazil. rfsanches@uol.com.br
FAU - Marques, Joao Mazzoncini de Azevedo
AU  - Marques JM
LA  - por
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Cannabis e humor.
PL  - Brazil
TA  - Braz J Psychiatry
JT  - Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
JID - 100895975
SB  - IM
MH  - Bipolar Disorder/chemically induced/psychology
MH  - Cannabis/*adverse effects
MH  - Depression/*chemically induced/diagnosis
MH  - Dose-Response Relationship, Drug
MH  - Humans
MH  - Marijuana Abuse/*complications
MH  - Marijuana Smoking/psychology
MH  - Mood Disorders/*chemically induced/diagnosis
EDAT- 2010/07/27 06:00
MHDA- 2011/03/25 06:00
CRDT- 2010/07/27 06:00
PHST- 2010/02/15 00:00 [received]
PHST- 2010/03/08 00:00 [accepted]
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2011/03/25 06:00 [medline]
AID - S1516-44462010000200014 [pii]
AID - 10.1590/s1516-44462010000200014 [doi]
PST - ppublish
SO  - Braz J Psychiatry. 2010 Jun;32(2):173-80. doi: 10.1590/s1516-44462010000200014.


PMID- 20658045
OWN - NLM
STAT- MEDLINE
DCOM- 20101213
LR  - 20191111
IS  - 1807-3107 (Electronic)
IS  - 1806-8324 (Linking)
VI  - 24
IP  - 2
DP  - 2010 Apr-Jun
TI  - Seal capability of interim post and core crown with temporary cements.
PG  - 238-44
LID - S1806-83242010000200018 [pii]
AB  - The purpose of the present study was to evaluate the in vitro seal capability of 
      interim post and core crown restorations. Eighty teeth were selected and divided 
      into 8 groups. Four experimental groups received interim posts and core crowns.
      Half of each group was decoronated at the cementum-enamel junction, groups PCCH
      and PCZO. The other half was sectioned 2 mm coronal to the cementum-enamel
      junction, groups PCrZO and PCrCH. The interim post and core crowns were luted
      with Rely X Temp NE, groups PCrZO and PCZO; Hydro C was used for Groups PCrCH and
      PCCH. The control groups, PC and PCr, received uncoated post and core crowns;
      groups OTg and OT were left without interim post and core crowns and were totally
      open. Infiltration was accessed by dye exposure followed by demineralization of
      the teeth. The length of the infiltration was measured using digital images taken
      from the specimens. The images were inserted into the Image Tool 3.0 software.
      Kruskal-Wallis analysis of variance and Dunn's multiple comparison method were
      used to test for significant differences among test groups (P < .05). Groups
      PCrZO and PCrCH showed the least dye penetration, followed by groups PCZO and
      PCCH. Teeth restored with interim post and core crowns will be subject to
      leakage. Ethics Committee: 095/2008.
FAU - Bonecker-Valverde, Guilherme
AU  - Bonecker-Valverde G
AD  - Department of Periodontics and Prosthodontics, Piracicaba Dental School,
      University of Campinas, Piracicaba, SP, Brazil. guigavalverde@yahoo.com
FAU - Maniglia-Ferreira, Claudio
AU  - Maniglia-Ferreira C
FAU - Abi-Rached, Gisele Priscila
AU  - Abi-Rached GP
FAU - Gomes, Brenda Paula Figueiredo de Almeida
AU  - Gomes BP
FAU - Mesquita, Marcelo Ferraz
AU  - Mesquita MF
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - Braz Oral Res
JT  - Brazilian oral research
JID - 101307187
RN  - 0 (Dental Cements)
RN  - 0 (Dental Materials)
SB  - IM
MH  - Analysis of Variance
MH  - *Crowns
MH  - Dental Cements/chemistry/*therapeutic use
MH  - Dental Leakage/*prevention & control
MH  - Dental Materials/therapeutic use
MH  - Dental Restoration, Temporary/methods
MH  - *Denture, Partial, Temporary
MH  - Humans
MH  - In Vitro Techniques
MH  - Materials Testing
MH  - *Post and Core Technique
MH  - Statistics, Nonparametric
MH  - Time Factors
MH  - Tooth Cervix
EDAT- 2010/07/27 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/07/27 06:00
PHST- 2010/01/05 00:00 [received]
PHST- 2010/04/29 00:00 [accepted]
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S1806-83242010000200018 [pii]
AID - 10.1590/s1806-83242010000200018 [doi]
PST - ppublish
SO  - Braz Oral Res. 2010 Apr-Jun;24(2):238-44. doi: 10.1590/s1806-83242010000200018.


PMID- 20657980
OWN - NLM
STAT- MEDLINE
DCOM- 20110105
LR  - 20220330
IS  - 1678-4464 (Electronic)
IS  - 0102-311X (Linking)
VI  - 26
IP  - 6
DP  - 2010 Jun
TI  - [Analysis of patient referral teams in mental health: a clinical management
      perspective].
PG  - 1153-62
LID - S0102-311X2010000600009 [pii]
AB  - The study used a qualitative, evaluative, and participant methodology based on
      Gadamer's hermeneutics and the constructivist paradigm. The aim was to analyze
      the arrangement called "patient care teams" for treatment of psychotic patients
      in the context of Community Mental Health Services (CMHS). Data were collected in
      two cycles of 18 focus groups including health professionals, users, and family
      members at six CMHS III, including eight in-depth interviews with users of these 
      services and two workshops aimed at developing a guide to evaluate CMHS
      practices. The arrangement's functions were described, emphasizing that the
      referral teams serve as clinical management levels, fostering follow-up of
      patients' unique needs in the field, through interdisciplinary work. This
      requires sustaining an ethical stance based on respect for otherness and clinical
      case work-up.
FAU - Miranda, Lilian
AU  - Miranda L
AD  - Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, Campinas,
      Brasil. limiranda78@hotmail.com
FAU - Onocko-Campos, Rosana T
AU  - Onocko-Campos RT
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Analise das equipes de referencia em saude mental: uma perspectiva de gestao da
      clinica.
PL  - Brazil
TA  - Cad Saude Publica
JT  - Cadernos de saude publica
JID - 8901573
SB  - IM
MH  - Focus Groups
MH  - Health Personnel/*organization & administration
MH  - Humans
MH  - *Interprofessional Relations
MH  - Mental Disorders/*therapy
MH  - Mental Health Services/*organization & administration
MH  - Patient Care Team/*organization & administration
EDAT- 2010/07/27 06:00
MHDA- 2011/01/06 06:00
CRDT- 2010/07/27 06:00
PHST- 2009/10/23 00:00 [received]
PHST- 2010/04/19 00:00 [accepted]
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2011/01/06 06:00 [medline]
AID - S0102-311X2010000600009 [pii]
AID - 10.1590/s0102-311x2010000600009 [doi]
PST - ppublish
SO  - Cad Saude Publica. 2010 Jun;26(6):1153-62. doi: 10.1590/s0102-311x2010000600009.


PMID- 20657524
OWN - NLM
STAT- MEDLINE
DCOM- 20101105
LR  - 20160210
IS  - 2329-0358 (Electronic)
IS  - 1425-9524 (Linking)
VI  - 15
IP  - 2
DP  - 2010 Apr-Jun
TI  - Ethical concerns in research trials involving living unrelated organ donors: a
      call for absolute prohibition.
PG  - 74-5
FAU - Khedmat, Hossein
AU  - Khedmat H
FAU - Taheri, Saeed
AU  - Taheri S
LA  - eng
PT  - Letter
PL  - United States
TA  - Ann Transplant
JT  - Annals of transplantation
JID - 9802544
SB  - IM
MH  - Clinical Trials as Topic/ethics
MH  - Humans
MH  - Informed Consent/ethics
MH  - Iran
MH  - Kidney Transplantation/*ethics
MH  - Living Donors/*ethics
MH  - Risk Factors
EDAT- 2010/07/27 06:00
MHDA- 2010/11/06 06:00
CRDT- 2010/07/27 06:00
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2010/11/06 06:00 [medline]
AID - 880945 [pii]
PST - ppublish
SO  - Ann Transplant. 2010 Apr-Jun;15(2):74-5.


PMID- 20657256
OWN - NLM
STAT- MEDLINE
DCOM- 20101215
LR  - 20161125
IS  - 1531-2291 (Electronic)
IS  - 0890-5339 (Linking)
VI  - 24
IP  - 8
DP  - 2010 Aug
TI  - A novel methodology for the study of injury mechanism: ankle fracture analysis
      using injury videos posted on YouTube.com.
PG  - 477-82
LID - 10.1097/BOT.0b013e3181c99264 [doi]
AB  - PURPOSE: An inherent deficiency in the understanding of the biomechanics of
      fractures is the reliance on cadaveric or other nonphysiological injury models
      resulting from the prohibitive ethical and practical considerations of conducting
      injury studies in live participants. We describe a novel methodology for studying
      injury mechanisms using in vivo injury videos obtained from Youtube.com
      demonstrating injuries as they occur in real time and correlating them with the
      resulting injury radiographs. METHODS: Over 1000 video clips of potential ankle
      fractures were assessed for clear visualization of the mechanism of injury,
      including the foot position and deforming force. Candidate videos were selected
      if the mechanism of injury was classifiable by those described by Lauge-Hansen
      and there appeared to be a significant mechanism to likely cause fracture. X-rays
      were then requested from the individuals posting the video clips. Videos and
      x-rays were reviewed and classified using the Lauge-Hansen system in a blinded
      manner. The deforming mechanism in the video clips was classified as supination
      external rotation, supination adduction (SAD), pronation external rotation (PER),
      or pronation abduction. X-ray fracture patterns were similarly classified.
      RESULTS: Two hundred forty videos were selected and individuals posting the
      videos were contacted. Of 96 initial positive responses, we collected 15 videos
      with their corresponding radiographs. Eight had SAD-deforming trauma and seven
      had PER-deforming trauma as appreciated in the videos. There were 12 true ankle
      fractures. All five fractures judged by video to be SAD injuries resulted in a
      corresponding SAD pattern radiographic ankle fractures. Of the seven fractures
      judged by video to be PER injuries, only two resulted in PER pattern radiographic
      ankle fractures. Five PER injuries resulted in supination external rotation ankle
      fracture patterns. CONCLUSION: Our series shows that when in vivo injury videos
      are matched to their corresponding x-rays, the Lauge-Hansen system is only 58%
      overall accurate in predicting fracture patterns from deforming injury mechanism 
      as pertaining to SAD and PER injury mechanisms. All SAD injuries correlated but
      only 29% of PER injuries resulted in a PER fracture pattern. This study
      illustrates the ethical and practical difficulties of using public access
      Internet YouTube videos for the study of injury dynamics. The current case series
      illustrates the method's potential and may lead to future research analyzing the 
      validity of the Lauge-Hansen classification system as applied to in vivo
      injuries.
FAU - Kwon, John Y
AU  - Kwon JY
AD  - Harvard Combined Orthopaedic Residency Program, Massachusetts General Hospital,
      Boston, MA, USA.
FAU - Chacko, Aron T
AU  - Chacko AT
FAU - Kadzielski, John J
AU  - Kadzielski JJ
FAU - Appleton, Paul T
AU  - Appleton PT
FAU - Rodriguez, Edward K
AU  - Rodriguez EK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Orthop Trauma
JT  - Journal of orthopaedic trauma
JID - 8807705
SB  - IM
MH  - Ankle Injuries/*diagnostic imaging/*etiology
MH  - Computer-Assisted Instruction/*methods
MH  - Data Mining/methods
MH  - Fractures, Bone/*diagnostic imaging
MH  - Humans
MH  - *Internet
MH  - Radiography
MH  - Traumatology/*education
MH  - United States
MH  - *Video Recording
EDAT- 2010/07/27 06:00
MHDA- 2010/12/16 06:00
CRDT- 2010/07/27 06:00
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2010/12/16 06:00 [medline]
AID - 10.1097/BOT.0b013e3181c99264 [doi]
AID - 00005131-201008000-00012 [pii]
PST - ppublish
SO  - J Orthop Trauma. 2010 Aug;24(8):477-82. doi: 10.1097/BOT.0b013e3181c99264.


PMID- 20657110
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20100726
IS  - 0973-3922 (Electronic)
IS  - 0378-6323 (Linking)
VI  - 76
IP  - 4
DP  - 2010 Jul-Aug
TI  - Skin manifestations of child abuse.
PG  - 317-26
LID - 10.4103/0378-6323.66572 [doi]
AB  - Child abuse is a major public health problem all over the world. There are four
      major types of abuse: physical abuse, sexual abuse, emotional abuse and neglect. 
      The most common manifestations of child abuse are cutaneous and their
      recognition; and differential diagnosis is of great importance. Clinicians,
      especially dermatologists, should be alert about the skin lesions of child abuse.
      In the diagnosis and management of child abuse, a multidisciplinary approach with
      ethical and legal procedures is necessary. In this manuscript, cutaneous
      manifestations of physical, sexual, emotional abuse and neglect are reviewed and 
      discussed.
FAU - Ermertcan, Aylin Turel
AU  - Ermertcan AT
AD  - Department of Dermatology, Celal Bayar University, Faculty of Medicine, Manisa,
      Turkey. draylinturel@hotmail.com
FAU - Ertan, Pelin
AU  - Ertan P
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Indian J Dermatol Venereol Leprol
JT  - Indian journal of dermatology, venereology and leprology
JID - 7701852
SB  - IM
MH  - Burns/*diagnosis/etiology
MH  - Child
MH  - Child Abuse/*diagnosis
MH  - Diagnosis, Differential
MH  - Humans
MH  - Skin/*injuries
MH  - Wounds and Injuries/*diagnosis/etiology
EDAT- 2010/07/27 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/07/27 06:00
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - ijdvl_2010_76_4_317_66572 [pii]
AID - 10.4103/0378-6323.66572 [doi]
PST - ppublish
SO  - Indian J Dermatol Venereol Leprol. 2010 Jul-Aug;76(4):317-26. doi:
      10.4103/0378-6323.66572.


PMID- 20657054
OWN - NLM
STAT- MEDLINE
DCOM- 20100923
LR  - 20100726
IS  - 0007-5140 (Print)
IS  - 0007-5140 (Linking)
VI  - 84
IP  - 2
DP  - 2010 Summer
TI  - Working ethics: William Beaumont, Alexis St. Martin, and medical research in
      antebellum America.
PG  - 193-216
LID - 10.1353/bhm.0.0341 [doi]
AB  - Analyzing William Beaumont's relationship with his experimental subject, Alexis
      St. Martin, this article demonstrates how the "research ethics" of antebellum
      America were predicated on models of employment, servitude, and labor. The
      association between Beaumont and St. Martin drew from and was understood in terms
      of the ideas and practices of contract labor, informal domestic servitude,
      indentures, and military service. Beaumont and St. Martin lived through an
      important period of transition in which personal master-servant relations existed
      alongside the "free" contract labor of market capitalism. Their relationship
      reflected and helped constitute important developments in nineteenth-century
      American labor history.
FAU - Green, Alexa
AU  - Green A
AD  - John Hopkins School of Medicine, MD, USA. alex.harcourt@gmail.com
LA  - eng
PT  - Biography
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - Bull Hist Med
JT  - Bulletin of the history of medicine
JID - 0141233
SB  - IM
MH  - Biomedical Research/history
MH  - Capitalism
MH  - Ethics, Research/*history
MH  - Gastroenterology/history
MH  - History, 19th Century
MH  - Humans
MH  - Interpersonal Relations
MH  - Physiology/history
MH  - Therapeutic Human Experimentation/history
PS  - Beaumont W
FPS - Beaumont, William
PS  - St Martin A
FPS - St Martin, Alexis
EDAT- 2010/07/27 06:00
MHDA- 2010/09/24 06:00
CRDT- 2010/07/27 06:00
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
AID - S1086317610200017 [pii]
AID - 10.1353/bhm.0.0341 [doi]
PST - ppublish
SO  - Bull Hist Med. 2010 Summer;84(2):193-216. doi: 10.1353/bhm.0.0341.


PMID- 20657027
OWN - NLM
STAT- MEDLINE
DCOM- 20101222
LR  - 20211020
IS  - 1460-2350 (Electronic)
IS  - 0268-1161 (Linking)
VI  - 25
IP  - 9
DP  - 2010 Sep
TI  - Why the Medical Research Council refused Robert Edwards and Patrick Steptoe
      support for research on human conception in 1971.
PG  - 2157-74
LID - 10.1093/humrep/deq155 [doi]
AB  - BACKGROUND: In 1971, Cambridge physiologist Robert Edwards and Oldham
      gynaecologist Patrick Steptoe applied to the UK Medical Research Council (MRC)
      for long-term support for a programme of scientific and clinical 'Studies on
      Human Reproduction'. The MRC, then the major British funder of medical research, 
      declined support on ethical grounds and maintained this policy throughout the
      1970s. The work continued with private money, leading to the birth of Louise
      Brown in 1978 and transforming research in obstetrics, gynaecology and human
      embryology. METHODS: The MRC decision has been criticized, but the processes by
      which it was reached have yet to be explored. Here, we present an archive-based
      analysis of the MRC decision. RESULTS: We find evidence of initial support for
      Edwards and Steptoe, including from within the MRC, which invited the applicants 
      to join its new directly funded Clinical Research Centre at Northwick Park
      Hospital. They declined the offer, preferring long-term grant support at the
      University of Cambridge, and so exposed the project to competitive funding mode. 
      Referees and the Clinical Research Board saw the institutional set-up in
      Cambridge as problematic with respect to clinical facilities and patient
      management; gave infertility a low priority compared with population control;
      assessed interventions as purely experimental rather than potential treatments,
      and so set the bar for safety high; feared fatal abnormalities and so wanted
      primate experiments first; and were antagonized by the applicants' high media
      profile. The rejection set MRC policy on IVF for 8 years, until, after the birth 
      of just two healthy babies, the Council rapidly converted to enthusiastic
      support. CONCLUSIONS: This analysis enriches our view of a crucial decision,
      highlights institutional opportunities and constraints and provides insight into 
      the then dominant attitudes of reproductive scientists and clinicians towards
      human conception research.
FAU - Johnson, Martin H
AU  - Johnson MH
AD  - Anatomy School and Trophoblast Research Centre, Department of Physiology,
      Development and Neuroscience, Anatomy School, University of Cambridge, Downing
      Street, Cambridge CB2 3DY, UK. mhj21@cam.ac.uk
FAU - Franklin, Sarah B
AU  - Franklin SB
FAU - Cottingham, Matthew
AU  - Cottingham M
FAU - Hopwood, Nick
AU  - Hopwood N
LA  - eng
GR  - 084418/Wellcome Trust/United Kingdom
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100724
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
SB  - IM
CIN - Hum Reprod. 2010 Sep;25(9):2156. PMID: 20657026
MH  - Academic Medical Centers/organization & administration
MH  - *Decision Making, Organizational
MH  - Embryo Research/economics/ethics/*history
MH  - Female
MH  - *Fertilization
MH  - Fertilization in Vitro/*history/psychology
MH  - Financing, Government/history
MH  - Health Priorities/economics/ethics
MH  - History, 20th Century
MH  - Humans
MH  - Infertility/therapy
MH  - Male
MH  - Peer Review, Research
MH  - Population Control
MH  - Reproduction
MH  - Research Support as Topic/*history
MH  - United Kingdom
PMC - PMC2922998
EDAT- 2010/07/27 06:00
MHDA- 2010/12/24 06:00
CRDT- 2010/07/27 06:00
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2010/12/24 06:00 [medline]
AID - deq155 [pii]
AID - 10.1093/humrep/deq155 [doi]
PST - ppublish
SO  - Hum Reprod. 2010 Sep;25(9):2157-74. doi: 10.1093/humrep/deq155. Epub 2010 Jul 24.


PMID- 20656845
OWN - NLM
STAT- MEDLINE
DCOM- 20100924
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 256
IP  - 2
DP  - 2010 Aug
TI  - Characterization of focal liver lesions by means of assessment of hepatic transit
      time with contrast-enhanced US.
PG  - 648-55
LID - 10.1148/radiol.10090715 [doi]
AB  - PURPOSE: To assess whether hepatic transit times (HTTs), as measured with
      contrast material-enhanced ultrasonography (US), can help predict the nature of
      focal liver lesions. MATERIALS AND METHODS: The study was approved by the local
      institutional ethics committee, with written informed patient consent. A total of
      402 patients were enrolled in the study. HTT, the time between the appearance of 
      the microbubble contrast agent in the hepatic artery and its appearance in the
      hepatic vein, was measured in the contrast pulse sequencing mode after injection 
      of a sulphur hexafluoride microbubble US contrast agent. Logistic regression was 
      used to identify factors indicative of the malignant or nonmalignant status of
      focal liver lesions. Receiver operating characteristic (ROC) analysis was
      performed to determine the predictive value of the HTT. RESULTS: Observed HTTs
      for malignant focal liver lesions (mean, 6.2 seconds; range, 2-10 seconds) were
      significantly lower than those for nonmalignant lesions (mean, 9.5 seconds;
      range, 4-25 seconds; P < .001). ROC analysis revealed cutoff values of 7 seconds 
      for HTT and 0.879 for area under the ROC curve. For HTTs of 7 seconds or shorter,
      hepatic malignancies were detected with a sensitivity of 79%, a specificity of
      80%, a positive predictive value of 53%, and a negative predictive value of 93%. 
      No malignant lesions had an HTT longer than 10 seconds. CONCLUSION: HTT alone
      could be a good predictor for nonmalignancy of focal liver lesions.
FAU - Zhou, Xiang
AU  - Zhou X
AD  - Department of Ultrasound, West China Hospital, Sichuan University, Guoxue Xiang
      37, Chengdu, Sichuan 610041, Peoples Republic of China. zhou .xiang@tom.com
FAU - Liu, Ji-Bin
AU  - Liu JB
FAU - Luo, Yan
AU  - Luo Y
FAU - Yan, Feng
AU  - Yan F
FAU - Peng, Yulan
AU  - Peng Y
FAU - Lin, Ling
AU  - Lin L
FAU - Zhuang, Hua
AU  - Zhuang H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - 0 (Phospholipids)
RN  - 0 (contrast agent BR1)
RN  - WS7LR3I1D6 (Sulfur Hexafluoride)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Algorithms
MH  - Computer Simulation
MH  - Contrast Media/pharmacokinetics
MH  - Female
MH  - Humans
MH  - Image Enhancement/methods
MH  - Image Interpretation, Computer-Assisted/*methods
MH  - Information Storage and Retrieval/*methods
MH  - Liver Diseases/*diagnostic imaging/*metabolism
MH  - Male
MH  - Metabolic Clearance Rate
MH  - Middle Aged
MH  - *Models, Biological
MH  - Phospholipids/*pharmacokinetics
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Sulfur Hexafluoride/*pharmacokinetics
MH  - Ultrasonography
MH  - Young Adult
EDAT- 2010/07/27 06:00
MHDA- 2010/09/25 06:00
CRDT- 2010/07/27 06:00
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2010/09/25 06:00 [medline]
AID - 256/2/648 [pii]
AID - 10.1148/radiol.10090715 [doi]
PST - ppublish
SO  - Radiology. 2010 Aug;256(2):648-55. doi: 10.1148/radiol.10090715.


PMID- 20656843
OWN - NLM
STAT- MEDLINE
DCOM- 20100924
LR  - 20220330
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 256
IP  - 2
DP  - 2010 Aug
TI  - Resting brain connectivity: changes during the progress of Alzheimer disease.
PG  - 598-606
LID - 10.1148/radiol.10091701 [doi]
AB  - PURPOSE: To investigate alterations in functional connectivity in the resting
      brain networks in healthy elderly volunteers and patients with mild, moderate, or
      severe Alzheimer Disease (AD). MATERIALS AND METHODS: This study was approved by 
      the institutional ethics committee, and informed consent was obtained. Forty-six 
      patients with AD and 16 healthy elderly volunteers were prospectively examined.
      Resting-state functional magnetic resonance imaging was used to detect
      alterations in posterior cingulate cortex (PCC) functional connectivity through a
      comparison of the healthy control group with three separate AD groups-mild,
      moderate, and severe AD. A temporal correlation method was used to obtain PCC
      connectivity maps. RESULTS: Dissociated functional connectivity between the PCC
      and a set of regions, including the visual cortices bilaterally, the inferior
      temporal cortex, the hippocampus, and especially the medial prefrontal cortex and
      the precuneus and/or cuneus, was observed in all AD groups. The disruption of
      connectivity intensified as the stage of AD progression increased. There were
      also regions that exhibited increased connectivity; these regions extended from
      left lateralized frontoparietal regions and spread to bilateral frontoparietal
      regions along with AD progression. CONCLUSION: Changes in PCC functional
      connectivity comprised bidirectional alterations in the resting networks in
      AD-affected brains, and the impaired resting functional connectivity seemed to
      change with AD progression. Therefore, alterations in functional connectivity in 
      the default mode network might play a role in the progression of AD.
FAU - Zhang, Hong-Ying
AU  - Zhang HY
AD  - Department of Radiology, Jiangsu Key Laboratory of Molecule Imaging and
      Functional Imaging, Medical School of Southeast University, 87 Dingjiaqiao Road, 
      Nanjing 210009, China.
FAU - Wang, Shi-Jie
AU  - Wang SJ
FAU - Liu, Bin
AU  - Liu B
FAU - Ma, Zhan-Long
AU  - Ma ZL
FAU - Yang, Ming
AU  - Yang M
FAU - Zhang, Zhi-Jun
AU  - Zhang ZJ
FAU - Teng, Gao-Jun
AU  - Teng GJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/diagnosis/*physiopathology
MH  - Brain/*physiopathology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Nerve Net/*physiopathology
MH  - Neural Pathways/*physiopathology
EDAT- 2010/07/27 06:00
MHDA- 2010/09/25 06:00
CRDT- 2010/07/27 06:00
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2010/09/25 06:00 [medline]
AID - 256/2/598 [pii]
AID - 10.1148/radiol.10091701 [doi]
PST - ppublish
SO  - Radiology. 2010 Aug;256(2):598-606. doi: 10.1148/radiol.10091701.


PMID- 20656842
OWN - NLM
STAT- MEDLINE
DCOM- 20100924
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 256
IP  - 2
DP  - 2010 Aug
TI  - Suspected carotid artery stenosis: cost-effectiveness of CT angiography in
      work-up of patients with recent TIA or minor ischemic stroke.
PG  - 585-97
LID - 10.1148/radiol.10091157 [doi]
AB  - PURPOSE: To assess the effectiveness and cost-effectiveness of state-of-the-art
      noninvasive diagnostic imaging strategies in patients with a transient ischemic
      attack (TIA) or minor stroke who are suspected of having carotid artery stenosis 
      (CAS). MATERIALS AND METHODS: All prospectively evaluated patients provided
      informed consent, and the local ethics committee approved this study. Diagnostic 
      performance, treatment, long-term events, quality of life, and costs resulting
      from strategies employing duplex ultrasonography (US), computed tomographic (CT) 
      angiography, contrast material-enhanced magnetic resonance (MR) angiography, and 
      combinations of these modalities were modeled in a decision tree and Markov
      model. Data sources included a prospective diagnostic cohort study, a
      meta-analysis, and a review of the literature. Outcomes were costs,
      quality-adjusted life-years (QALYs), incremental cost-effectiveness ratios, and
      net health benefits (QALY-equivalents), with a willingness-to-pay threshold of
      euro 50,000 per QALY and a societal perspective. The strategy with the highest
      net health benefit was considered the most cost effective. Extensive one-way,
      two-way, and probabilistic sensitivity analyses to explore the effect of varying 
      parameter values were performed. The reference case analysis assumed that
      patients underwent surgery 2-4 weeks after the first symptoms, and the effect of 
      earlier intervention was explored. RESULTS: The reference case analysis showed
      that duplex US combined with CT angiography and surgery for 70%-99% stenoses was 
      the most cost-effective strategy, with a net health benefit of 13.587 and 15.542 
      QALY-equivalents in men and women, respectively. In men, the CT angiography
      strategy with a 70%-99% cutoff yielded slightly more QALYs, at an incremental
      cost of euro 71,419 per QALY, compared with duplex US combined with CT
      angiography. In patients with a high-risk profile, in patients with a high prior 
      probability of disease, and when patients could be treated within 2 weeks after
      the first symptoms, the CT angiography strategy with surgery for 50%-99% stenoses
      was the most cost-effective strategy. CONCLUSION: In diagnosing CAS, duplex US
      should be the initial test, and, if its results are positive, CT angiography
      should be performed; patients with 70%-99% stenoses should then undergo carotid
      endarterectomy. In patients with a high-risk profile, a high probability of CAS, 
      or who can undergo surgery without delay, immediate CT angiography and surgery
      for 50%-99% stenoses is indicated.
FAU - Tholen, Aletta T R
AU  - Tholen AT
AD  - Department of Radiology, Erasmus University Medical Center, PO Box 2040, 3000 CA 
      Rotterdam, the Netherlands.
FAU - de Monye, Cecile
AU  - de Monye C
FAU - Genders, Tessa S S
AU  - Genders TS
FAU - Buskens, Erik
AU  - Buskens E
FAU - Dippel, Diederik W J
AU  - Dippel DW
FAU - van der Lugt, Aad
AU  - van der Lugt A
FAU - Hunink, M G Myriam
AU  - Hunink MG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Angiography/*economics/*statistics & numerical data
MH  - Carotid Stenosis/*diagnostic imaging/*economics/epidemiology
MH  - Comorbidity
MH  - Cost-Benefit Analysis
MH  - Female
MH  - Health Care Costs/*statistics & numerical data
MH  - Humans
MH  - Ischemic Attack, Transient/*diagnostic imaging/*economics/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Tomography, X-Ray Computed/*economics/statistics & numerical data
MH  - Young Adult
EDAT- 2010/07/27 06:00
MHDA- 2010/09/25 06:00
CRDT- 2010/07/27 06:00
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2010/09/25 06:00 [medline]
AID - 256/2/585 [pii]
AID - 10.1148/radiol.10091157 [doi]
PST - ppublish
SO  - Radiology. 2010 Aug;256(2):585-97. doi: 10.1148/radiol.10091157.


PMID- 20656841
OWN - NLM
STAT- MEDLINE
DCOM- 20100924
LR  - 20220409
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 256
IP  - 2
DP  - 2010 Aug
TI  - Ocular adnexal lymphoma: diffusion-weighted mr imaging for differential diagnosis
      and therapeutic monitoring.
PG  - 565-74
LID - 10.1148/radiol.10100086 [doi]
AB  - PURPOSE: To describe the magnetic resonance (MR) imaging and diffusion-weighted
      (DW) imaging features of ocular adnexal lymphomas (OALs), to determine the
      diagnostic accuracy of apparent diffusion coefficient (ADC) for discriminating
      OALs from other orbital mass lesions, and to assess whether variations in ADC
      constitute a reliable biomarker of OAL response to therapy. MATERIALS AND
      METHODS: Institutional ethical committee approval and informed consent were
      obtained. In this prospective study, 114 white subjects (65 females and 49 males)
      were enrolled. Thirty-eight patients with histopathologically proved OAL
      underwent serial MR and DW imaging examination of the orbits. ADCs of OALs were
      compared with those of normal orbital structures, obtained in 18 healthy
      volunteers, and other orbital mass lesions, prospectively acquired in 58 patients
      (20 primary non-OAL neoplasms, 15 vascular benign lesions, 12 inflammatory
      lesions, 11 metastases). Interval change in ADC of OALs before and after
      treatment was analyzed in 29 patients. Analysis of covariance and a paired t test
      were used for statistical analysis. RESULTS: Baseline ADCs in OALs were lower
      than those in normal structures and other orbital diseases (P < .001). An ADC
      threshold of 775 x 10(-6) mm(2)/sec resulted in 96% sensitivity, 93% specificity,
      88% positive predictive value, 98.2% negative predictive value, and 94.4%
      accuracy in OAL diagnosis. Following appropriate treatment, 10 (34%) of 29
      patients showed OAL volumetric reduction, accompanied (n = 7) or preceded (n = 3)
      by an increase in ADC (P = .005). Conversely, a further reduction of ADC was
      observed in the seven patients who experienced disease progression (P < .05).
      CONCLUSION: ADC permits accurate diagnosis of OALs. Interval change in ADC after 
      therapy represents a helpful tool for predicting therapeutic response.
FAU - Politi, Letterio S
AU  - Politi LS
AD  - Department of Neuroradiology and Neuroradiology Research Unit, San Raffaele
      Scientific Institute, Via Olgettina 60, 20132 Milan, Italy. politi.letterio@hsr
      .it
FAU - Forghani, Reza
AU  - Forghani R
FAU - Godi, Claudia
AU  - Godi C
FAU - Resti, Antonio G
AU  - Resti AG
FAU - Ponzoni, Maurilio
AU  - Ponzoni M
FAU - Bianchi, Stefania
AU  - Bianchi S
FAU - Iadanza, Antonella
AU  - Iadanza A
FAU - Ambrosi, Alessandro
AU  - Ambrosi A
FAU - Falini, Andrea
AU  - Falini A
FAU - Ferreri, Andres J M
AU  - Ferreri AJ
FAU - Curtin, Hugh D
AU  - Curtin HD
FAU - Scotti, Giuseppe
AU  - Scotti G
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antineoplastic Agents/*therapeutic use
MH  - Child
MH  - Child, Preschool
MH  - Diagnosis, Differential
MH  - Diffusion Magnetic Resonance Imaging/*methods
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Lymphoma, Large B-Cell, Diffuse/*diagnosis/*drug therapy
MH  - Male
MH  - Middle Aged
MH  - Orbital Neoplasms/*diagnosis/*drug therapy
MH  - Prognosis
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2010/07/27 06:00
MHDA- 2010/09/25 06:00
CRDT- 2010/07/27 06:00
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2010/09/25 06:00 [medline]
AID - 256/2/565 [pii]
AID - 10.1148/radiol.10100086 [doi]
PST - ppublish
SO  - Radiology. 2010 Aug;256(2):565-74. doi: 10.1148/radiol.10100086.


PMID- 20656836
OWN - NLM
STAT- MEDLINE
DCOM- 20100924
LR  - 20151119
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 256
IP  - 2
DP  - 2010 Aug
TI  - Nonalcoholic fatty liver disease: detection of elevated nicotinamide adenine
      dinucleotide phosphate with in vivo 3.0-T 31P MR spectroscopy with proton
      decoupling.
PG  - 466-73
LID - 10.1148/radiol.10091351 [doi]
AB  - PURPOSE: To determine if 3.0-T proton-decoupled phosphorus 31 ((31)P) magnetic
      resonance (MR) spectroscopy can be used to differentiate between stages of
      nonalcoholic fatty liver disease (NAFLD) by resolving the components of
      phosphomonoester (PME) and phosphodiester (PDE) and enabling detection of a
      greater number of other phosphorus-containing compounds. MATERIALS AND METHODS:
      This study was approved by the ethics committee of Helsinki University Central
      Hospital, and written informed consent was obtained from all study subjects. A
      3.0-T clinical imager was used to obtain proton-decoupled (31)P MR spectra in the
      liver of control subjects (n = 12), patients with biopsy-proved simple steatosis 
      due to nonalcoholic causes (nonalcoholic fatty liver, n = 13; nonalcoholic
      steatohepatitis [NASH], n = 9), and patients with cirrhosis (n = 9) to determine 
      PME, phosphoethanolamine (PE), phosphocholine, PDE, glycerophosphocholine (GPC), 
      glycerophosphoryl ethanolamine, uridine diphosphoglucose, nicotinamide adenine
      dinucleotide phosphate (NADPH), inorganic phosphate, phosphoenolpyruvate, and
      alpha-, beta- and gamma-nucleotide triphosphate levels. Liver fat was determined 
      with hydrogen 1 MR spectroscopy. Differences between the disease groups were
      analyzed with one-way analysis of variance. RESULTS: The PME/(PME + PDE),
      PME/PDE, and PE/(PME + PDE) ratios were higher and the GPC/(PME + PDE) ratio was 
      lower in patients with cirrhosis than in the other study groups (P < or = .001,
      one-way analysis of variance). The NADPH/(PME + PDE) ratio was higher in patients
      with NASH and those with cirrhosis than in control subjects (P < .05, post hoc
      analyses) and correlated with disease severity (P = .007). CONCLUSION: NADPH, a
      marker of inflammation and fibrinogenic activity in the liver, is increased in
      patients with NASH and those with cirrhosis. Proton-decoupled (31)P 3.0-T MR
      spectroscopy shows promise in the differentiation of NAFLD stages.
FAU - Sevastianova, Ksenia
AU  - Sevastianova K
AD  - Department of Medicine, Division of Diabetes, University of Helsinki, PO Box 340,
      Helsinki 00029 HUCH, Finland.
FAU - Hakkarainen, Antti
AU  - Hakkarainen A
FAU - Kotronen, Anna
AU  - Kotronen A
FAU - Corner, Anja
AU  - Corner A
FAU - Arkkila, Perttu
AU  - Arkkila P
FAU - Arola, Johanna
AU  - Arola J
FAU - Westerbacka, Jukka
AU  - Westerbacka J
FAU - Bergholm, Robert
AU  - Bergholm R
FAU - Lundbom, Jesper
AU  - Lundbom J
FAU - Lundbom, Nina
AU  - Lundbom N
FAU - Yki-Jarvinen, Hannele
AU  - Yki-Jarvinen H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Biomarkers)
RN  - 0 (Phosphorus Isotopes)
RN  - 53-59-8 (NADP)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alcoholism/diagnosis/metabolism
MH  - Biomarkers/analysis
MH  - Diagnosis, Computer-Assisted/*methods
MH  - Fatty Liver/diagnosis/*metabolism
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Spectroscopy/*methods
MH  - Male
MH  - Middle Aged
MH  - NADP/*analysis
MH  - Phosphorus Isotopes/analysis
MH  - Photons
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Young Adult
EDAT- 2010/07/27 06:00
MHDA- 2010/09/25 06:00
CRDT- 2010/07/27 06:00
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2010/09/25 06:00 [medline]
AID - 256/2/466 [pii]
AID - 10.1148/radiol.10091351 [doi]
PST - ppublish
SO  - Radiology. 2010 Aug;256(2):466-73. doi: 10.1148/radiol.10091351.


PMID- 20656831
OWN - NLM
STAT- MEDLINE
DCOM- 20100924
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 256
IP  - 2
DP  - 2010 Aug
TI  - Mammographic features of breast cancers at single reading with computer-aided
      detection and at double reading in a large multicenter prospective trial of
      computer-aided detection: CADET II.
PG  - 379-86
LID - 10.1148/radiol.10091899 [doi]
AB  - PURPOSE: To evaluate the mammographic features of breast cancer that favor lesion
      detection with single reading and computer-aided detection (CAD) or with double
      reading. MATERIALS AND METHODS: The Computer Aided Detection Evaluation Trial II 
      study was approved by the ethics committee, and all participants provided written
      informed consent. A total of 31,057 women were recruited from three screening
      centers between September 2006 and August 2007. They were randomly allocated to
      the double reading group, the single reading with CAD group, or the double
      reading and single reading with CAD group at a ratio of 1:1:28, respectively. In 
      this study, cancers in the women whose mammograms were read with both single
      reading with CAD and double reading were retrospectively reviewed. The original
      mammograms were obtained for each case and reviewed by two of three experienced
      breast radiologists in consensus. The method of detection was noted. The size and
      predominant mammographic feature of the cancer were recorded, as was the breast
      density. CAD marking data were reviewed to determine if the cancer had been
      correctly marked. RESULTS: A total of 227 cancers were detected in 28,204 women. 
      A total of 170 cases were recalled with both reading regimens. Lesion types were 
      masses (66%), microcalcifications (25%), parenchymal deformities (6%), and
      asymmetric densities (3%). The ability of the reading regimens to correctly
      prompt the reader to recall cases varied significantly by lesion type (P < .001).
      More parenchymal deformities were recalled with double reading, whereas more
      asymmetric densities were recalled with single reading with CAD. There was no
      difference in the ability of either reading regimen to prompt the reader to
      correctly recall masses or microcalcifications. CAD correctly prompted 100% of
      microcalcifications, 87% of mass lesions, 80% of asymmetric densities, and 50% of
      parenchymal deformities. CAD correctly marked 93% of spiculated masses compared
      with 80% of ill-defined masses (P = .054). There was a significant trend for
      cancers detected with double reading to occur only in women with a denser
      mammographic background pattern (P = .02). Size had no effect on lesion
      detection. CONCLUSION: Readers using either single reading with CAD or double
      reading need to be aware of the strengths and weaknesses of reading regimens to
      avoid missing the more challenging cancer cases.
FAU - James, Jonathan J
AU  - James JJ
AD  - Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, Scotland.
      jonathan.james@nuh.nhs.uk
FAU - Gilbert, Fiona J
AU  - Gilbert FJ
FAU - Wallis, Matthew G
AU  - Wallis MG
FAU - Gillan, Maureen G C
AU  - Gillan MG
FAU - Astley, Susan M
AU  - Astley SM
FAU - Boggis, Caroline R M
AU  - Boggis CR
FAU - Agbaje, Olorunsola F
AU  - Agbaje OF
FAU - Brentnall, Adam R
AU  - Brentnall AR
FAU - Duffy, Stephen W
AU  - Duffy SW
LA  - eng
GR  - Cancer Research UK/United Kingdom
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Algorithms
MH  - Breast Neoplasms/*diagnostic imaging/*epidemiology
MH  - England/epidemiology
MH  - Female
MH  - Humans
MH  - Mammography/*statistics & numerical data
MH  - Middle Aged
MH  - Observer Variation
MH  - Prevalence
MH  - Prospective Studies
MH  - Radiographic Image Interpretation, Computer-Assisted/*methods
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Young Adult
EDAT- 2010/07/27 06:00
MHDA- 2010/09/25 06:00
CRDT- 2010/07/27 06:00
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2010/09/25 06:00 [medline]
AID - 256/2/379 [pii]
AID - 10.1148/radiol.10091899 [doi]
PST - ppublish
SO  - Radiology. 2010 Aug;256(2):379-86. doi: 10.1148/radiol.10091899.


PMID- 20656790
OWN - NLM
STAT- MEDLINE
DCOM- 20101222
LR  - 20191210
IS  - 1460-2350 (Electronic)
IS  - 0268-1161 (Linking)
VI  - 25
IP  - 9
DP  - 2010 Sep
TI  - Activation of Toll-like receptor 5 decreases the attachment of human trophoblast 
      cells to endometrial cells in vitro.
PG  - 2217-28
LID - 10.1093/humrep/deq185 [doi]
AB  - BACKGROUND: Embryo implantation in the uterus involves the trophoblast cells
      apposing and adhering to, then invading across the epithelium lining of the
      endometrium. However, ethical concerns regarding experimentation with primary
      human tissue during this period of life necessitates creation of in vitro models 
      for understanding the basic mechanisms involved. Toll-like receptors (TLRs) play 
      a crucial role in defence against pathogens invading the female reproductive
      tract. The objective of this study is to establish and optimize an in vitro model
      for studying human endometrial embryonic interactions and to understand the
      effect of TLR5 stimulation on the attachment of trophoblast cells to endometrial 
      cells. METHODS: By using a human telomerase immortalized endometrial epithelial
      cell line (hTERT-EECs) and choriocarcinoma human trophoblast cells (JAr cells),
      an in vitro assay of human implantation was established. In order to investigate 
      the impact of TLR5 stimulation on attachment in this assay, bacterial flagellin
      was applied to the endometrial and trophoblast cells. In order to block TLR5 in
      the endometrial and trophoblast cells, TLR5 function-blocking antibody was
      applied to the cells prior to flagellin treatment. RESULTS: The results
      demonstrated that JAr spheroids attached to hTERT-EECs in a time and
      concentration-dependent manner. Our results also demonstrated that treatment of
      endometrial cells with flagellin, suppressed the attachment of JAr spheres to the
      endometrial cells. Application of TLR5 function-blocking antibody significantly
      restored the attachment of JAr spheres to the endometrium. CONCLUSIONS: These
      data suggest a novel mechanism by which the presence of intrauterine infection
      through TLR5 activation may result in implantation failure. These data may
      provide a new opportunity in the management of infertility cases.
FAU - Aboussahoud, Wedad
AU  - Aboussahoud W
AD  - Academic Unit of Reproductive and Developmental Medicine, The University of
      Sheffield, Level 4, Jessop Wing, Tree Root Walk, Sheffield S10 2SF, UK.
FAU - Bruce, Chris
AU  - Bruce C
FAU - Elliott, Sarah
AU  - Elliott S
FAU - Fazeli, Alireza
AU  - Fazeli A
LA  - eng
PT  - Journal Article
PT  - Validation Study
DEP - 20100723
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
RN  - 0 (TLR5 protein, human)
RN  - 0 (Toll-Like Receptor 5)
RN  - 12777-81-0 (Flagellin)
SB  - IM
MH  - Bacterial Infections/immunology/physiopathology
MH  - Cell Adhesion
MH  - Cell Line
MH  - Coculture Techniques
MH  - *Embryo Implantation
MH  - Endometrium/*physiology
MH  - Female
MH  - Flagellin/immunology
MH  - Humans
MH  - Immunity, Innate
MH  - Kinetics
MH  - Osmolar Concentration
MH  - Spheroids, Cellular/cytology/physiology
MH  - Toll-Like Receptor 5/immunology/*physiology
MH  - Trophoblasts/*physiology
EDAT- 2010/07/27 06:00
MHDA- 2010/12/24 06:00
CRDT- 2010/07/27 06:00
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2010/12/24 06:00 [medline]
AID - deq185 [pii]
AID - 10.1093/humrep/deq185 [doi]
PST - ppublish
SO  - Hum Reprod. 2010 Sep;25(9):2217-28. doi: 10.1093/humrep/deq185. Epub 2010 Jul 23.


PMID- 20656558
OWN - NLM
STAT- MEDLINE
DCOM- 20101210
LR  - 20220330
IS  - 1473-0502 (Print)
IS  - 1473-0502 (Linking)
VI  - 43
IP  - 1
DP  - 2010 Aug
TI  - Clinical studies of the effect of blood storage on patient outcomes.
PG  - 95-106
LID - 10.1016/j.transci.2010.05.013 [doi]
AB  - It is indisputable that there are numerous biochemical, structural, inflammatory,
      and physiologic changes in stored red cells, sometimes referred to collectively
      as the "red cell storage lesion". It remains controversial however whether any of
      these changes have clinical relevance and actually impact the clinical outcomes
      in transfused patients. More than 25 published clinical studies have evaluated
      the effects of red blood cell storage on patient outcomes. The majority of
      studies are non-randomized observational studies with methodologic limitations
      described in this review. These studies do however provide equipoise to support
      the ethical conduct of the large, definitive randomized clinical trials which are
      now underway.
CI  - (c) 2010. Published by Elsevier Ltd.
FAU - Triulzi, Darrell J
AU  - Triulzi DJ
AD  - Division of Transfusion Medicine, Department of Pathology, University of
      Pittsburgh, PA, USA. tri0075lzi@pitt.edu
FAU - Yazer, Mark H
AU  - Yazer MH
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100724
PL  - England
TA  - Transfus Apher Sci
JT  - Transfusion and apheresis science : official journal of the World Apheresis
      Association : official journal of the European Society for Haemapheresis
JID - 101095653
MH  - Blood Preservation/*methods
MH  - Erythrocyte Transfusion/methods
MH  - *Erythrocytes
MH  - Humans
MH  - Treatment Outcome
EDAT- 2010/07/27 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/07/27 06:00
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S1473-0502(10)00096-0 [pii]
AID - 10.1016/j.transci.2010.05.013 [doi]
PST - ppublish
SO  - Transfus Apher Sci. 2010 Aug;43(1):95-106. doi: 10.1016/j.transci.2010.05.013.
      Epub 2010 Jul 24.


PMID- 20656286
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20100830
IS  - 1578-1860 (Electronic)
IS  - 0014-2565 (Linking)
VI  - 210
IP  - 8
DP  - 2010 Sep
TI  - [Conflictive patients in the emergency room: Definition, classification and
      ethical aspects].
PG  - 404-9
LID - 10.1016/j.rce.2010.03.007 [doi]
AB  - A conflictive patient is one who provokes a problem (a conflict) by their
      attitude or behavior for the physician. Ethical conflicts in emergency care are
      common and many of them occur with these patients. Among the most common types of
      patients who generate personal conflicts with health professionals are overly
      demanding patients, those who refuse medical interventions, those who are
      aggressive, litigators, excessively-recurrent users of the heath system and those
      who go to the emergency room without an urgent condition. A patient may include
      several of these profiles ("mixed" patient). When they appear, the approach
      should be, if possible, by a team, establishing a deliberative process. If there 
      is doubt and when possible, the ethics committee of the institution should be
      consulted, seeking the protocols, this best being institutional, on the subject. 
      After that, if the decision is difficult, support must be sought from the
      emergency staff and even management. The whole process should be reflected in the
      clinical history. Specific education in bioethics and communication skills can be
      of great help to minimize and cope better with long-term conflicts.
CI  - Copyright 2009 Elsevier Espana, S.L. All rights reserved.
FAU - Herreros, B
AU  - Herreros B
AD  - Medicina Interna, Hospital Universitario Fundacion Alcorcon, Madrid, Espana.
      benjaminherreros@gmail.com
FAU - Garcia Casasola, G
AU  - Garcia Casasola G
FAU - Pintor, E
AU  - Pintor E
FAU - Sanchez, M A
AU  - Sanchez MA
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Paciente conflictivo en urgencias: definicion, tipologia y aspectos eticos.
DEP - 20100724
PL  - Spain
TA  - Rev Clin Esp
JT  - Revista clinica espanola
JID - 8608576
SB  - IM
MH  - *Dissent and Disputes
MH  - Emergency Service, Hospital/*ethics
MH  - Humans
MH  - Patients/*classification
EDAT- 2010/07/27 06:00
MHDA- 2011/01/07 06:00
CRDT- 2010/07/27 06:00
PHST- 2009/12/14 00:00 [received]
PHST- 2010/02/23 00:00 [revised]
PHST- 2010/03/15 00:00 [accepted]
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
AID - S0014-2565(10)00284-5 [pii]
AID - 10.1016/j.rce.2010.03.007 [doi]
PST - ppublish
SO  - Rev Clin Esp. 2010 Sep;210(8):404-9. doi: 10.1016/j.rce.2010.03.007. Epub 2010
      Jul 24.


PMID- 20656266
OWN - NLM
STAT- MEDLINE
DCOM- 20101105
LR  - 20191210
IS  - 1532-8473 (Electronic)
IS  - 1089-9472 (Linking)
VI  - 25
IP  - 4
DP  - 2010 Aug
TI  - Publication ethics: conflicts, copyright, permission, and authorship.
PG  - 263-71
LID - 10.1016/j.jopan.2010.05.006 [doi]
FAU - Carlson, Kathlyn
AU  - Carlson K
AD  - Abbott-Northwestern Hospital, 6005 Morgan Avenue South, Minneapolis, MN 55419,
      USA. KMCedits@msn.com
FAU - Ross, Jacqueline
AU  - Ross J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Perianesth Nurs
JT  - Journal of perianesthesia nursing : official journal of the American Society of
      PeriAnesthesia Nurses
JID - 9610507
MH  - *Authorship
MH  - *Conflict, Psychological
MH  - Copyright/*ethics
MH  - Humans
MH  - *Perioperative Nursing
MH  - Publications/*ethics
EDAT- 2010/07/27 06:00
MHDA- 2010/11/06 06:00
CRDT- 2010/07/27 06:00
PHST- 2010/05/08 00:00 [received]
PHST- 2010/05/11 00:00 [accepted]
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2010/11/06 06:00 [medline]
AID - S1089-9472(10)00237-6 [pii]
AID - 10.1016/j.jopan.2010.05.006 [doi]
PST - ppublish
SO  - J Perianesth Nurs. 2010 Aug;25(4):263-71. doi: 10.1016/j.jopan.2010.05.006.


PMID- 20656062
OWN - NLM
STAT- MEDLINE
DCOM- 20110309
LR  - 20220408
IS  - 1542-7714 (Electronic)
IS  - 1542-3565 (Linking)
VI  - 8
IP  - 12
DP  - 2010 Dec
TI  - Helicobacter pylori eradication therapy research: Ethical issues and description 
      of results.
PG  - 1032-6
LID - 10.1016/j.cgh.2010.07.002 [doi]
AB  - As an infectious disease, the approach to anti-Helicobacter pylori therapy
      differs from other common gastrointestinal conditions because treatment success
      of more than 90% to 95% should be expected and the reasons for treatment failure 
      can always be understood. Neither comparisons with another regimen nor
      randomization are required to identify a highly successful therapy. Treatment
      success should be judged first in relation to outcome (ie, >/=95% or grade A).
      Inclusion of a known inferior regimen in a clinical trial is generally unethical.
      If the use of a known inferior drug is required by a regulatory agency, subjects 
      must be given full and accurate information regarding expectations with each
      regimen; there can be no deceptions. Comparative trials should be restricted to
      highly successful treatments (ie, comparisons of different doses, durations,
      compliance, cost, and so forth). Success should be judged as ordered categories
      such as <85%, 85%-89%, 90%-94%, or >/=95% and statistically equivalent regimens
      with the same grade success (ie, 90%-94% [Grade B]) are inferior to those higher 
      category (ie, >/=95% [Grade A]) regimens. Only grade A or B regimens should be
      prescribed. Here we discuss anti-H pylori eradication studies from the
      perspective [corrected] of an infectious disease with the goal of providing
      recommendations regarding changes in approach and in reporting that should help
      resolve the ethical issues and make the results of clinical trials more useful to
      clinicians.
CI  - Copyright (c) 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.
FAU - Graham, David Y
AU  - Graham DY
AD  - Department of Medicine, Molecular Virology and Microbiology, Michael E. DeBakey
      Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas,
      USA. dgraham@bcm
LA  - eng
GR  - DK56338/DK/NIDDK NIH HHS/United States
GR  - R21DK067366/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20100723
PL  - United States
TA  - Clin Gastroenterol Hepatol
JT  - Clinical gastroenterology and hepatology : the official clinical practice journal
      of the American Gastroenterological Association
JID - 101160775
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
EIN - Clin Gastroenterol Hepatol. 2011 Mar;9(3):280
MH  - Anti-Bacterial Agents/*therapeutic use
MH  - Biomedical Research/*ethics/methods
MH  - *Clinical Trials as Topic
MH  - Drug Therapy, Combination/methods
MH  - Helicobacter Infections/*drug therapy
MH  - Humans
MH  - Treatment Outcome
EDAT- 2010/07/27 06:00
MHDA- 2011/03/10 06:00
CRDT- 2010/07/27 06:00
PHST- 2010/06/02 00:00 [received]
PHST- 2010/07/06 00:00 [revised]
PHST- 2010/07/07 00:00 [accepted]
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2011/03/10 06:00 [medline]
AID - S1542-3565(10)00679-8 [pii]
AID - 10.1016/j.cgh.2010.07.002 [doi]
PST - ppublish
SO  - Clin Gastroenterol Hepatol. 2010 Dec;8(12):1032-6. doi:
      10.1016/j.cgh.2010.07.002. Epub 2010 Jul 23.


PMID- 20655628
OWN - NLM
STAT- MEDLINE
DCOM- 20111006
LR  - 20120910
IS  - 1532-2793 (Electronic)
IS  - 0260-6917 (Linking)
VI  - 31
IP  - 5
DP  - 2011 Jul
TI  - Continuing education of paediatric nurses in Vojvodina, Serbia.
PG  - 461-5
LID - 10.1016/j.nedt.2010.06.007 [doi]
AB  - UNLABELLED: The purpose of this study was to identify the need and degree of
      interest for continuing education of paediatric nurses at the Institute for Child
      and Youth Health Care of Vojvodina. DESIGN: Descriptive study with prospective
      approach, which involved the use of surveys to elicit data collection. Data were 
      collected during January and May of 2008. RESULTS: In this study 94% of
      paediatric nurses who participated in the study have secondary education in
      nursing, and 80% have not attended any forms of continuing education thus far,
      and 8% had presented papers at national seminars. No forms of continuing
      education were found dominant, while nurses with less years of work experience,
      showed statistically much greater interest in continuing education. CONCLUSION:
      Paediatric nurses in this study show the need for moral, ethical, and financial
      support from their supervisors and employers to realize their interest in
      continuing education, in accordance with their individual abilities. IMPLICATION 
      FOR PRACTICE: Information about the specific educational needs of paediatric
      nurses in terms of content and methods provide a valuable guide for planning the 
      effective continuing education programs, seminars, and professional conferences
      for improving clinical practice and providing exemplary nursing care to children.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Brestovacki, Branislava
AU  - Brestovacki B
AD  - Institute for Child and Youth Health Care of Vojvodina, Serbia. bb1@eunet.rs
FAU - Milutinovic, Dragana
AU  - Milutinovic D
LA  - eng
PT  - Journal Article
DEP - 20100723
PL  - Scotland
TA  - Nurse Educ Today
JT  - Nurse education today
JID - 8511379
MH  - *Attitude of Health Personnel
MH  - Child
MH  - Clinical Competence
MH  - *Education, Nursing, Continuing/methods
MH  - Humans
MH  - Nursing Staff, Hospital/*psychology/statistics & numerical data
MH  - Pediatric Nursing/*education
MH  - Prospective Studies
MH  - Serbia
EDAT- 2010/07/27 06:00
MHDA- 2011/10/07 06:00
CRDT- 2010/07/27 06:00
PHST- 2009/07/15 00:00 [received]
PHST- 2010/06/05 00:00 [revised]
PHST- 2010/06/15 00:00 [accepted]
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2011/10/07 06:00 [medline]
AID - S0260-6917(10)00116-4 [pii]
AID - 10.1016/j.nedt.2010.06.007 [doi]
PST - ppublish
SO  - Nurse Educ Today. 2011 Jul;31(5):461-5. doi: 10.1016/j.nedt.2010.06.007. Epub
      2010 Jul 23.


PMID- 20654970
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20100726
IS  - 1769-664X (Electronic)
IS  - 0929-693X (Linking)
VI  - 17
IP  - 6
DP  - 2010 Jun
TI  - [Children living with life-limiting conditions: practices and ethical aspects in 
      France].
PG  - 938-9
LID - 10.1016/S0929-693X(10)70188-3 [doi]
FAU - Garbi, A
AU  - Garbi A
AD  - Faculte de Medecine, EA 3783, 13385 Marseille, France. aurelie.garbi@ap-hm.fr
FAU - Le Coz, P
AU  - Le Coz P
LA  - fre
PT  - Journal Article
TT  - L'enfant en fin de vie: aspects pratiques et ethiques.
PL  - France
TA  - Arch Pediatr
JT  - Archives de pediatrie : organe officiel de la Societe francaise de pediatrie
JID - 9421356
SB  - IM
MH  - Child
MH  - Chronic Disease/*therapy
MH  - Cooperative Behavior
MH  - Decision Making/ethics
MH  - *Ethics, Medical
MH  - France
MH  - Humans
MH  - Interdisciplinary Communication
MH  - Medical Futility/*ethics/legislation & jurisprudence
MH  - Professional-Family Relations
MH  - Resuscitation Orders/*ethics/legislation & jurisprudence
MH  - Terminal Care/*ethics/legislation & jurisprudence
EDAT- 2010/07/27 06:00
MHDA- 2011/01/07 06:00
CRDT- 2010/07/27 06:00
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
AID - S0929-693X(10)70188-3 [pii]
AID - 10.1016/S0929-693X(10)70188-3 [doi]
PST - ppublish
SO  - Arch Pediatr. 2010 Jun;17(6):938-9. doi: 10.1016/S0929-693X(10)70188-3.


PMID- 20654850
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20171116
IS  - 1769-664X (Electronic)
IS  - 0929-693X (Linking)
VI  - 17
IP  - 6
DP  - 2010 Jun
TI  - [Ethics, aesthetic and human dignity].
PG  - 702-3
LID - 10.1016/S0929-693X(10)70068-3 [doi]
FAU - Valentin, C
AU  - Valentin C
AD  - Universite Rene-Descartes, Paris V, France. valentinclaude@hotmail.com
LA  - fre
PT  - Journal Article
TT  - Ethique, esthetique et dignite humaine.
PL  - France
TA  - Arch Pediatr
JT  - Archives de pediatrie : organe officiel de la Societe francaise de pediatrie
JID - 9421356
SB  - IM
MH  - Darkness
MH  - *Esthetics
MH  - *Ethics, Medical
MH  - Female
MH  - Fetal Development/*physiology
MH  - Humans
MH  - Infant, Newborn
MH  - Medicine in the Arts
MH  - *Personhood
MH  - Philosophy, Medical
MH  - Pregnancy
MH  - Symbolism
EDAT- 2010/07/27 06:00
MHDA- 2011/01/07 06:00
CRDT- 2010/07/27 06:00
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
AID - S0929-693X(10)70068-3 [pii]
AID - 10.1016/S0929-693X(10)70068-3 [doi]
PST - ppublish
SO  - Arch Pediatr. 2010 Jun;17(6):702-3. doi: 10.1016/S0929-693X(10)70068-3.


PMID- 20654276
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20100726
IS  - 1646-0758 (Electronic)
IS  - 0870-399X (Linking)
VI  - 23
IP  - 3
DP  - 2010 May-Jun
TI  - [Contagion - some notes on the epistemology and the ethics of public health].
PG  - 533-56
AB  - European Medical thought on epidemics - ranging from the opposition clean/dirty, 
      pollution, malaria, pestilential seeds to 19th century microbiology - has always 
      been ruled by figures such as the miasma, the repulsive, the excrement, the
      filth, the corrupt, the contagion. Theoretically framed, in general, by
      Foucault's ideas, this research focuses on some aspects of the historical
      epistemology and ethics of Public Health. Based on the history of Tuberculosis
      (TB) management in Portugal and, more briefly, on the flu pandemics, we thematize
      aspects of Biopolitics, namely, the disciplinary power and the processes of
      indifferentiation and reification. We will focus on the disjunction between
      contamination and transmission, on the systems of inclusion and exclusion and on 
      the differences between uncertainty, risk, danger, precaution and prevention,
      aiming to contribute to the public debate on an ethic of precaution. It will be
      attested that the praxis of Public Health inevitably calls together, at various
      levels, the old categories of medical ethos, among which are the catharsis, the
      crisis, and the kairos.
FAU - Marques, Manuel Silverio
AU  - Marques MS
AD  - Centro de Filosofia, Universidade de Lisboa, Lisboa.
FAU - Ferreira, Carlos Miguel
AU  - Ferreira CM
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Contagio - contribuicao para a epistemologia e a etica da saude publica.
DEP - 20100614
PL  - Portugal
TA  - Acta Med Port
JT  - Acta medica portuguesa
JID - 7906803
SB  - IM
MH  - *Communicable Disease Control
MH  - Epidemics/*ethics
MH  - Humans
MH  - Influenza, Human/epidemiology
MH  - *Knowledge
MH  - Pandemics
MH  - Public Health/*ethics
MH  - Risk Factors
EDAT- 2010/07/27 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/07/27 06:00
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - Acta Med Port. 2010 May-Jun;23(3):533-56. Epub 2010 Jun 14.


PMID- 20654268
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20100726
IS  - 1646-0758 (Electronic)
IS  - 0870-399X (Linking)
VI  - 23
IP  - 3
DP  - 2010 May-Jun
TI  - [Bioethical reflections about the situation of the elderly and their families].
PG  - 483-92
AB  - The progresses of medicine, by increasing longevity, as well as in geriatrics, by
      improving the elderly's quality of life led to an understanding of old age based 
      on the therapeutic metaphor. This fact, imbued with positive consequences, yet
      culturally reinforced by the ideology of perfect health, caused an increasing
      medicalization of old age, considered a disease to be cured. One of the first
      perceptions of the human beings' ageing process is gaining awareness of their
      vulnerability. Individuals start to realize that they no longer have the energy
      and vitality they once had and, therefore, are more vulnerable and fragile in
      face of biological or psychological factors tending towards the imbalance.
      Illness is the exact metaphor of vulnerability and suffering is the bitter face
      of that experience. The human being is a being destined to die. The death process
      is part of the life event. For life to be possible, it is necessary for death to 
      take place continuously. During the ageing process, the human being is confronted
      with other dimensions that may have already been forgotten, due to the feeling of
      power and Independence experienced during youth and adult life. Today, being old 
      is a problem! In the course of time, people reached naturally old age, for ageing
      is a part of life. But, in our days, for the first time in History, being old has
      become a problem. The bottom-line ethical issue is, therefore, socio-cultural.
      And this because, on one hand, there isn't a place for the elderly in the
      contemporary society as it used to happen in pre-modern social contexts, and on
      the other hand, the culture itself does no longer supply (as before) additional
      symbolic references to help them face this new step of their lives. As such, the 
      principles of Bioethics - autonomy, beneficence, nonmaleficence and justice -
      could pave the way towards ethical guidelines that could help third age. General 
      Practice/Family Medicine, as a specialty based on globality and continuity of
      care, can and should represent an important factor of social integration of the
      elderly in the community, while fostering their autonomy and reducing their
      institutionalization in order to achieve a greater quality of life.
FAU - Simoes, Jose Augusto
AU  - Simoes JA
AD  - Disciplina de Etica, Escola Superior de Saude, Universidade de Aveiro, Aveiro.
LA  - por
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Reflexao bioetica sobre a situacao do idoso e sua familia.
DEP - 20100614
PL  - Portugal
TA  - Acta Med Port
JT  - Acta medica portuguesa
JID - 7906803
SB  - IM
MH  - *Aged
MH  - Aging
MH  - *Bioethical Issues
MH  - *Family
MH  - Humans
EDAT- 2010/07/27 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/07/27 06:00
PHST- 2008/06/24 00:00 [received]
PHST- 2009/05/25 00:00 [accepted]
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - Acta Med Port. 2010 May-Jun;23(3):483-92. Epub 2010 Jun 14.


PMID- 20653988
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20191210
IS  - 1741-203X (Electronic)
IS  - 1041-6102 (Linking)
VI  - 23
IP  - 1
DP  - 2011 Feb
TI  - A validated risk score to estimate mortality risk in patients with dementia and
      pneumonia: barriers to clinical impact.
PG  - 31-43
LID - 10.1017/S1041610210001079 [doi]
AB  - BACKGROUND: The clinical impact of risk score use in end-of-life settings is
      unknown, with reports limited to technical properties. METHODS: We conducted a
      mixed-methods study to evaluate clinical impact of a validated mortality risk
      score aimed at informing prognosis and supporting clinicians in decision-making
      in dementia patients with pneumonia. We performed a trial (n = 69) with
      physician-reported outcomes referring to the score's aims. Subsequently,
      physician focus group discussions were planned to better understand barriers to
      clinical impact, and we surveyed families (n = 50) and nurses practicing in
      nursing homes (n = 29). We finally consulted with experts and key persons for
      implementation. RESULTS: Most (71%) physicians who used the score considered it
      useful, but mainly for its learning effects. Families were never informed of
      numerical risk estimates. Two focus group discussions revealed a reluctance to
      use a numerical approach, and physicians found that outcomes conditional on
      antibiotic treatment were inadequate to support decision-making. Nurses varied in
      their perceived role in informing families. Most families (88%) wished to be
      informed, preferring a numerical (43%), verbalized (35%), or other approach (18%)
      or had no preference (5%). Revising the score, we added an ethical framework for 
      decision-making to acknowledge its complexity, an explanatory note addressing
      barriers related to physicians' attitudes, and a nurses' form. CONCLUSION: The
      combined quantitative and qualitative studies elicited: substantial barriers to a
      numerical approach to physicians' end-of-life decision-making; crucial
      information for revisions and further score development; and a need for
      implementation strategies that focus on education.
FAU - van der Steen, Jenny T
AU  - van der Steen JT
AD  - VU University Medical Center, EMGO Institute for Health and Care Research,
      Department of Nursing Home Medicine, Amsterdam, The Netherlands.
      j.vandersteen@vumc.nl
FAU - Albers, Gwenda
AU  - Albers G
FAU - Licht-Strunk, Els
AU  - Licht-Strunk E
FAU - Muller, Martien T
AU  - Muller MT
FAU - Ribbe, Miel W
AU  - Ribbe MW
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20100726
PL  - England
TA  - Int Psychogeriatr
JT  - International psychogeriatrics
JID - 9007918
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anti-Bacterial Agents/therapeutic use
MH  - Decision Making
MH  - Dementia/complications/*mortality
MH  - Female
MH  - *Homes for the Aged
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nurses
MH  - *Nursing Homes
MH  - Physicians
MH  - Pneumonia/complications/drug therapy/*mortality
MH  - Prognosis
MH  - *Risk Assessment
MH  - Severity of Illness Index
MH  - Terminal Care
EDAT- 2010/07/27 06:00
MHDA- 2011/07/27 06:00
CRDT- 2010/07/27 06:00
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
AID - S1041610210001079 [pii]
AID - 10.1017/S1041610210001079 [doi]
PST - ppublish
SO  - Int Psychogeriatr. 2011 Feb;23(1):31-43. doi: 10.1017/S1041610210001079. Epub
      2010 Jul 26.


PMID- 20653849
OWN - NLM
STAT- MEDLINE
DCOM- 20101004
LR  - 20100726
IS  - 1467-789X (Electronic)
IS  - 1467-7881 (Linking)
VI  - 11
IP  - 1
DP  - 2010 Jan
TI  - Retractions: guidance from the Committee on Publication Ethics (COPE).
PG  - 64-6
LID - 10.1111/j.1467-789X.2009.00702.x [doi]
FAU - Wager, E
AU  - Wager E
FAU - Barbour, V
AU  - Barbour V
FAU - Yentis, S
AU  - Yentis S
FAU - Kleinert, S
AU  - Kleinert S
CN  - COPE Council
LA  - eng
PT  - Guideline
PT  - Journal Article
PL  - England
TA  - Obes Rev
JT  - Obesity reviews : an official journal of the International Association for the
      Study of Obesity
JID - 100897395
SB  - IM
MH  - Editorial Policies
MH  - Humans
MH  - Periodicals as Topic/standards
MH  - Publishing/*ethics/*standards
MH  - *Retraction of Publication as Topic
MH  - Scientific Misconduct
EDAT- 2010/07/27 06:00
MHDA- 2010/10/05 06:00
CRDT- 2010/07/27 06:00
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2010/10/05 06:00 [medline]
AID - OBR702 [pii]
AID - 10.1111/j.1467-789X.2009.00702.x [doi]
PST - ppublish
SO  - Obes Rev. 2010 Jan;11(1):64-6. doi: 10.1111/j.1467-789X.2009.00702.x.


PMID- 20653553
OWN - NLM
STAT- MEDLINE
DCOM- 20101015
LR  - 20191111
IS  - 1876-1429 (Electronic)
IS  - 1876-1429 (Linking)
VI  - 2
IP  - 1
DP  - 2010 Jan
TI  - Antimicrobial agents deriving from indigenous plants.
PG  - 83-92
AB  - Phytonutrients in many indigenous plants are receiving a lot of attention as they
      are important in antimicrobial and anticancer therapies. Tropical areas,
      especially India, South America and Africa, are the main sources of patentable
      plant products and have indigenous populations with well developed traditional
      medicinal knowledge. Phytochemicals, including carotenoids, phenolics, alkaloids,
      nitrogen-containing compounds, and organosulfur compounds, are receiving much
      attention as they impart important health benefits. This article gives an insight
      into some important phytochemicals, and analyses the ethical issues on property
      rights of plant products. Many patent applications have been lodged, and quite a 
      number have been granted. Pharmaceutical industries are engaging in massive
      speculative bioprospecting on plant based phytochemicals and products, usually
      resulting in conflicts with indigenous populations. More focus is given here-in
      to Tylosema esculentum (marama) plant, found in drier parts of Southern Africa
      and known to contain high quantities of essential phytochemicals. Important
      phytochemicals in marama include fatty acid (mainly oleic acid, linoleic acid,
      linolenic acid, behenic acid), protein and phenolic acid components. The marama
      plant has high potential as a source of medical and cosmetic products. If
      conflicts surrounding property rights on plant based products are resolved,
      phytochemicals can be a good source of income for indigenous populations in areas
      where such plants are found.
FAU - Avrelija, Cencic
AU  - Avrelija C
AD  - Department of Microbiology, Biochemistry, Molecular Biology and Biotechnology,
      University of Maribor, Faculty of Agriculture and Life Sciences, Pivola 10, 2311 
      Hoce, Slovenia. avrelija.cencic@uni-mb.si
FAU - Walter, Chingwaru
AU  - Walter C
LA  - eng
PT  - Journal Article
PL  - United Arab Emirates
TA  - Recent Pat Food Nutr Agric
JT  - Recent patents on food, nutrition & agriculture
JID - 101526178
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Anti-Bacterial Agents/*isolation & purification
MH  - Humans
MH  - *Patents as Topic
MH  - Plants/*chemistry
MH  - *Plants, Medicinal
EDAT- 2010/07/27 06:00
MHDA- 2010/10/16 06:00
CRDT- 2010/07/27 06:00
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2010/10/16 06:00 [medline]
AID - 10.2174/2212798411002010083 [doi]
PST - ppublish
SO  - Recent Pat Food Nutr Agric. 2010 Jan;2(1):83-92. doi:
      10.2174/2212798411002010083.


PMID- 20653263
OWN - NLM
STAT- MEDLINE
DCOM- 20100813
LR  - 20100726
IS  - 1547-1896 (Print)
IS  - 0893-7400 (Linking)
VI  - 23
IP  - 6
DP  - 2010 Jun
TI  - Is mandatory influenza vaccination for health care workers ethically permissible?
PG  - 56, 58
FAU - Rice, Ralph
AU  - Rice R
AD  - Department of Physician Assistant Studies, Wake Forest University School of
      Medicine, Winston-Salem, North Carolina, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - JAAPA
JT  - JAAPA : official journal of the American Academy of Physician Assistants
JID - 9513102
RN  - 0 (Influenza Vaccines)
MH  - Attitude of Health Personnel
MH  - *Health Personnel
MH  - Humans
MH  - Influenza Vaccines/*administration & dosage
MH  - Influenza, Human/*prevention & control
MH  - Mandatory Programs/*ethics
EDAT- 2010/07/27 06:00
MHDA- 2010/08/14 06:00
CRDT- 2010/07/27 06:00
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2010/08/14 06:00 [medline]
PST - ppublish
SO  - JAAPA. 2010 Jun;23(6):56, 58.


PMID- 20653250
OWN - NLM
STAT- MEDLINE
DCOM- 20100820
LR  - 20191111
IS  - 1054-6863 (Print)
IS  - 1054-6863 (Linking)
VI  - 20
IP  - 2
DP  - 2010 Jun
TI  - Cognitive enhancement, cheating, and accomplishment.
PG  - 145-60
AB  - An ethics of enhancement should not rest on blanket judgments; it should ask us
      to distinguish between the kinds of activities we want to enhance. Both students 
      and academics have turned to cognition-enhancing drugs in significant
      numbers--but is their enhancement a form of cheating? The answer should hinge on 
      whether the activity subject to enhancement is zero-sum or non-zero-sum, and
      whether one is more concerned with excellence in process or excellence in
      outcome. Cognitive enhancement should be especially tolerated when the activities
      at stake are non-zero-sum and when the importance of process is outweighed by the
      importance of outcome. The use of cognition-enhancing drugs does not unnaturally 
      cheapen accomplishments achieved under their influence; instead, cognitive
      enhancement is in line with well-established conceptions of collaborative
      authorship, which shift the locus of praise and blame from individual creators to
      the ultimate products of their efforts.
FAU - Goodman, Rob
AU  - Goodman R
AD  - George Washington University, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Kennedy Inst Ethics J
JT  - Kennedy Institute of Ethics journal
JID - 9109135
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Nootropic Agents)
RN  - 207ZZ9QZ49 (Methylphenidate)
RN  - R3UK8X3U3D (Modafinil)
RN  - TZ47U051FI (Dextroamphetamine)
SB  - IM
MH  - *Achievement
MH  - Benzhydryl Compounds/administration & dosage
MH  - Central Nervous System Stimulants/*administration & dosage
MH  - Choice Behavior/ethics
MH  - *Cognition/ethics
MH  - *Deception
MH  - Dextroamphetamine/administration & dosage
MH  - Humans
MH  - Methylphenidate/administration & dosage
MH  - Modafinil
MH  - Nootropic Agents/*administration & dosage
MH  - *Social Perception
MH  - Virtues
EDAT- 2010/07/27 06:00
MHDA- 2010/08/21 06:00
CRDT- 2010/07/27 06:00
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2010/08/21 06:00 [medline]
AID - 10.1353/ken.0.0309 [doi]
PST - ppublish
SO  - Kennedy Inst Ethics J. 2010 Jun;20(2):145-60. doi: 10.1353/ken.0.0309.


PMID- 20653249
OWN - NLM
STAT- MEDLINE
DCOM- 20100820
LR  - 20191111
IS  - 1054-6863 (Print)
IS  - 1054-6863 (Linking)
VI  - 20
IP  - 2
DP  - 2010 Jun
TI  - Better than men? Sex and the therapy/enhancement distinction.
PG  - 115-44
AB  - The normative significance of the distinction between therapy and enhancement has
      come under sustained philosophical attack in recent discussions of the ethics of 
      shaping future persons by means of advanced genetic technologies. Giving up the
      idea that whether a condition is normal or not should play a crucial role in
      assessing the ethics of genetic interventions has unrecognized and strongly
      counterintuitive implications when it comes to selecting what sort of children
      should be brought into the world. According to standard philosophical accounts of
      the factors one should take into account when making such decisions, women are
      "better than men." Given the biological differences between the sexes, then, if
      the only concern is the capacities of an embryo rather than its capacities
      relative to some normatively significant baseline, there is compelling reason to 
      choose only female embryos. In order to avoid this radical and counterintuitive
      conclusion, one must embrace the idea that both sexes are normal. The strength of
      the prima facie reasons to select or reject embryos depends on their sex, which
      is to say that it depends on the normal capacities of their sex. The
      therapy/enhancement distinction therefore plays a crucial role in determining the
      ethics of interventions into the genetics of future generations.
FAU - Sparrow, Robert
AU  - Sparrow R
AD  - Centre for Human Bioethics, Faculty of Arts, Monash University, Victoria,
      Australia.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Kennedy Inst Ethics J
JT  - Kennedy Institute of Ethics journal
JID - 9109135
SB  - IM
MH  - Choice Behavior/*ethics
MH  - Ethical Analysis
MH  - Female
MH  - Genetic Enhancement/*ethics
MH  - Genetic Therapy/*ethics
MH  - Human Characteristics
MH  - Humans
MH  - Male
MH  - Sex Preselection/*ethics
MH  - *Social Values
EDAT- 2010/07/27 06:00
MHDA- 2010/08/21 06:00
CRDT- 2010/07/27 06:00
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2010/08/21 06:00 [medline]
AID - 10.1353/ken.0.0308 [doi]
PST - ppublish
SO  - Kennedy Inst Ethics J. 2010 Jun;20(2):115-44. doi: 10.1353/ken.0.0308.


PMID- 20653248
OWN - NLM
STAT- MEDLINE
DCOM- 20100820
LR  - 20191111
IS  - 1054-6863 (Print)
IS  - 1054-6863 (Linking)
VI  - 20
IP  - 2
DP  - 2010 Jun
TI  - The ethics of research on enhancement interventions.
PG  - 101-13
AB  - Biomedical enhancement interventions to make people stronger, smarter, and
      happier are currently being developed. Research to assess these enhancements
      should be conducted before their introduction into clinical practice. But, many
      worry that enhancement research is unethical. Some contend that the practice of
      biomedical enhancements is unethical; accordingly, research that enables such
      practice would be unethical. Others suggest that research on enhancement
      interventions does not promote health, exposing research participants to risks
      with no potential compensating health benefits either to themselves or to
      society. Categorically condemning research on biomedical enhancements as
      unethical is unwarranted, however, since at least some research on biomedical
      enhancements is likely to produce significant health benefits. Indeed, under
      certain circumstances enhancement research would be urgent, as it would address
      major public health concerns. Therefore, a blanket prohibition on enhancement
      research is unjustified. Instead, like any other clinical research, each proposed
      enhancement study should be reviewed individually to assess whether it fulfills
      the ethical requirements that make a clinical study permissible.
FAU - Lev, Ori
AU  - Lev O
AD  - Department of Bioethics, Warren G. Magnuson Clinical Center, National Institutes 
      of Health, Bethesda, MD, USA.
FAU - Miller, Franklin G
AU  - Miller FG
FAU - Emanuel, Ezekiel J
AU  - Emanuel EJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Kennedy Inst Ethics J
JT  - Kennedy Institute of Ethics journal
JID - 9109135
SB  - IM
MH  - Biomedical Enhancement/*ethics
MH  - Biomedical Research/*ethics
MH  - Ethics, Medical
MH  - Ethics, Research
MH  - Humans
MH  - Public Health
MH  - Safety
EDAT- 2010/07/27 06:00
MHDA- 2010/08/21 06:00
CRDT- 2010/07/27 06:00
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2010/08/21 06:00 [medline]
AID - 10.1353/ken.0.0314 [doi]
PST - ppublish
SO  - Kennedy Inst Ethics J. 2010 Jun;20(2):101-13. doi: 10.1353/ken.0.0314.


PMID- 20653247
OWN - NLM
STAT- MEDLINE
DCOM- 20100820
LR  - 20100726
IS  - 1054-6863 (Print)
IS  - 1054-6863 (Linking)
VI  - 20
IP  - 2
DP  - 2010 Jun
TI  - Ethical issues in enhancement technologies.
PG  - vii-viii
LA  - eng
PT  - Introductory Journal Article
PL  - United States
TA  - Kennedy Inst Ethics J
JT  - Kennedy Institute of Ethics journal
JID - 9109135
SB  - IM
MH  - Biomedical Enhancement/*ethics
MH  - Genetic Enhancement/ethics
MH  - Humans
EDAT- 2010/07/27 06:00
MHDA- 2010/08/21 06:00
CRDT- 2010/07/27 06:00
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2010/08/21 06:00 [medline]
PST - ppublish
SO  - Kennedy Inst Ethics J. 2010 Jun;20(2):vii-viii.


PMID- 20653143
OWN - NLM
STAT- MEDLINE
DCOM- 20100916
LR  - 20100726
IS  - 0038-0814 (Print)
IS  - 0038-0814 (Linking)
IP  - 746
DP  - 2010 Jun
TI  - [Ethics committee in favor of interdiction of surrogate gestation].
PG  - S5
FAU - Haroche, Aurelie
AU  - Haroche A
LA  - fre
PT  - News
TT  - Le Comite d'ethique en faveur de l'interdiction de la gestation pour autrui.
PL  - France
TA  - Soins
JT  - Soins; la revue de reference infirmiere
JID - 20910580R
MH  - Dissent and Disputes
MH  - Ethics Committees/*organization & administration
MH  - France
MH  - Humans
MH  - Surrogate Mothers/*legislation & jurisprudence
EDAT- 2010/07/27 06:00
MHDA- 2010/09/18 06:00
CRDT- 2010/07/27 06:00
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2010/09/18 06:00 [medline]
PST - ppublish
SO  - Soins. 2010 Jun;(746):S5.


PMID- 20653122
OWN - NLM
STAT- MEDLINE
DCOM- 20100824
LR  - 20100726
IS  - 1330-0164 (Print)
IS  - 1330-0164 (Linking)
VI  - 64
IP  - 1
DP  - 2010 Mar
TI  - [Cesarean section on request because of labor pain--bioethical and legal views].
PG  - 25-32
AB  - Non-medical reasons that influence the decision to perform cesarean section are
      the subject of numerous medical and bioethical debates. The questions to be
      answered are: can a pregnant woman demand cesarean section based on her right to 
      make decisions, i.e. on patient rights? Do such a request and permission given by
      the woman justify the physician to perform the procedure without clear medical
      indication, knowing that cesarean section is associated with higher maternal
      morbidity and mortality rate than vaginal delivery? Among the numerous reasons
      stated by pregnant women or their families when demanding cesarean section, this 
      paper is focused on labor pain. The experience of pain during delivery is the
      result of many complex physiologic and psychosocial factors that act on the
      woman's personal interpretation of the nociceptive delivery stimuli. A mother's
      request for cesarean section should not be motivated by the lack of efficiency of
      pain management. Such motivation points to inadequate prenatal care and patient
      education offered by the obstetrician and anesthesiologist. Decisions to perform 
      cesarean section upon request are not in accordance with the guidelines of
      declarations and codes of medical ethics, and have no legal basis in our country.
FAU - Frkovic, Aleksandra
AU  - Frkovic A
FAU - Boskovic, Zvonko
AU  - Boskovic Z
LA  - hrv
PT  - English Abstract
PT  - Journal Article
TT  - Carski rez na zahtjev zbog porodne boli--bioeticki i pravni pogledi.
PL  - Croatia
TA  - Acta Med Croatica
JT  - Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti
JID - 9208249
SB  - IM
MH  - *Bioethics
MH  - *Cesarean Section
MH  - Croatia
MH  - Female
MH  - Humans
MH  - Labor Pain/psychology
MH  - *Patient Participation/legislation & jurisprudence
MH  - Pregnancy
EDAT- 2010/07/27 06:00
MHDA- 2010/08/25 06:00
CRDT- 2010/07/27 06:00
PHST- 2010/07/27 06:00 [entrez]
PHST- 2010/07/27 06:00 [pubmed]
PHST- 2010/08/25 06:00 [medline]
PST - ppublish
SO  - Acta Med Croatica. 2010 Mar;64(1):25-32.


PMID- 20653004
OWN - NLM
STAT- MEDLINE
DCOM- 20101028
LR  - 20161125
IS  - 1098-2345 (Electronic)
IS  - 0275-2565 (Linking)
VI  - 72
IP  - 9
DP  - 2010 Sep
TI  - Putting the community back in community ecology and education: the role of field 
      schools and private reserves in the ethical training of primatologists.
PG  - 785-93
LID - 10.1002/ajp.20837 [doi]
AB  - In 1993 and 1999, with the assistance of a Nicaraguan family, we founded La
      Suerte Biological Research Station in northeastern Costa Rica and Ometepe
      Biological Research Station in southern Nicaragua as a privately owned
      conservation-oriented business. Our goal was to develop a program of sustainable 
      community ecology focused on education, research, and the conservation of
      primates and tropical forests. In order to accomplish this we developed field
      courses in which undergraduate and graduate students conduct scientific research,
      experience local cultures, and learn about conservation. Over 120 of these
      students have received doctoral degrees or are currently in graduate programs.
      Four doctoral dissertations, several MA theses, and some 20 scientific articles
      have been published based on research conducted at our field stations. In order
      to achieve our long-term goals of preserving the environment, we also needed to
      engage directly with local communities to address their needs and concerns. To
      this end, we developed a series of community-based initiatives related to health 
      care, bilingual education, and conservation education using traditional and
      on-line teaching tools. In this article, we describe our efforts in Costa Rica
      and Nicaragua teaching conservation-oriented field courses and working with the
      local human communities. Building upon these experiences, we outline a set of
      ethical considerations and responsibilities for private reserves,
      conservation-oriented businesses, NGOs, and conservancies that help integrate
      members of the local community as stakeholders in conservation.
CI  - (c) 2010 Wiley-Liss, Inc.
FAU - Garber, P A
AU  - Garber PA
AD  - Department of Anthropology, University of Illinois, Urbana, IL 61801, USA.
      p-garber@Illinois.edu
FAU - Molina, A
AU  - Molina A
FAU - Molina, R L
AU  - Molina RL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Primatol
JT  - American journal of primatology
JID - 8108949
SB  - IM
MH  - Animals
MH  - Community Participation/*methods
MH  - *Community-Institutional Relations
MH  - Conservation of Natural Resources/*methods
MH  - Costa Rica
MH  - Ecology/*education/ethics
MH  - Humans
MH  - Nicaragua
MH  - *Primates
MH  - Zoology/*education/ethics
EDAT- 2010/07/24 06:00
MHDA- 2010/10/29 06:00
CRDT- 2010/07/24 06:00
PHST- 2010/07/24 06:00 [entrez]
PHST- 2010/07/24 06:00 [pubmed]
PHST- 2010/10/29 06:00 [medline]
AID - 10.1002/ajp.20837 [doi]
PST - ppublish
SO  - Am J Primatol. 2010 Sep;72(9):785-93. doi: 10.1002/ajp.20837.


PMID- 20653003
OWN - NLM
STAT- MEDLINE
DCOM- 20101028
LR  - 20100723
IS  - 1098-2345 (Electronic)
IS  - 0275-2565 (Linking)
VI  - 72
IP  - 9
DP  - 2010 Sep
TI  - Ethics commentary: subjects of knowledge and control in field primatology.
PG  - 779-84
LID - 10.1002/ajp.20840 [doi]
AB  - Our primate kin are routinely displaced from their habitats, hunted for meat,
      captured for trade, housed in zoos, made to perform for our entertainment, and
      used as subjects in biomedical testing. They are also the subjects of research
      inquiries by field primatologists. In this article, we place primate field
      studies on a continuum of human and alloprimate relationships as a heuristic
      device to explore the unifying ethical implications of such inter-relationships, 
      as well as address specific ethical challenges arising from common research
      protocols "in the field" (e.g. risks associated with habituation, disease
      transmission, invasive collection of biological samples, etc.). Additionally, we 
      question the widespread deployment of conservation- and/or local economic
      development-based justifications for field-based primatological pursuits.
      Informed by decades of combined fieldwork experience in Indonesia and the
      Democratic Republic of Congo, we demonstrate the process by which the adherence
      to a particular ethical calculus can lead to unregulated and ethically
      problematic research agendas. In conclusion, we offer several suggestions to
      consider in the establishment of a formalized code of ethics for field
      primatology.
CI  - (c) 2010 Wiley-Liss, Inc.
FAU - Malone, N M
AU  - Malone NM
AD  - Department of Anthropology, University of Auckland, Auckland, New Zealand.
      n.malone@auckland.ac.nz
FAU - Fuentes, A
AU  - Fuentes A
FAU - White, F J
AU  - White FJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Primatol
JT  - American journal of primatology
JID - 8108949
SB  - IM
MH  - Animals
MH  - *Animals, Wild
MH  - Codes of Ethics
MH  - *Endangered Species
MH  - *Ethics, Research
MH  - Humans
MH  - *Primates
MH  - Zoology/*ethics/standards
EDAT- 2010/07/24 06:00
MHDA- 2010/10/29 06:00
CRDT- 2010/07/24 06:00
PHST- 2010/07/24 06:00 [entrez]
PHST- 2010/07/24 06:00 [pubmed]
PHST- 2010/10/29 06:00 [medline]
AID - 10.1002/ajp.20840 [doi]
PST - ppublish
SO  - Am J Primatol. 2010 Sep;72(9):779-84. doi: 10.1002/ajp.20840.


PMID- 20653002
OWN - NLM
STAT- MEDLINE
DCOM- 20101028
LR  - 20161125
IS  - 1098-2345 (Electronic)
IS  - 0275-2565 (Linking)
VI  - 72
IP  - 9
DP  - 2010 Sep
TI  - Long-term field studies: positive impacts and unintended consequences.
PG  - 772-8
LID - 10.1002/ajp.20830 [doi]
AB  - Long-term field studies of wild primates can have far-reaching impacts that
      transcend their contributions to science. These impacts can benefit not only the 
      study animals, study areas, and local human communities, but they can also have
      unintended, potentially negative consequences. Examples of some of the positive
      impacts from the Northern Muriqui Project of Caratinga, in Minas Gerais, Brazil, 
      include contributions to conservation efforts on behalf of this critically
      endangered species, capacity building through the training of Brazilian students,
      and employment opportunities for local people through our collaboration with a
      locally administered NGO that is facilitating ecotourism, education, and
      reforestation programs. Some concerns about unintended consequences of the
      research include the effects of our trails and trail traffic on surrounding
      vegetation and other aspects of the environmental "footprints" that both
      long-term researchers and short-term visitors may leave. In addition, although
      precautions against potential health risks from routine exposure to human
      observers are now standard protocol, little is known about the other ways in
      which our long-term research presence can affect the primates' experiences or
      alter their perceptions of their social and ecological environments. Risk
      analysis, which weighs both the positive and negative impacts can provide useful 
      perspectives for addressing the ethical considerations that can arise during
      long-term field studies.
CI  - (c) 2010 Wiley-Liss, Inc.
FAU - Strier, Karen B
AU  - Strier KB
AD  - Department of Anthropology, University of Wisconsin-Madison, Madison, WI 53705,
      USA. kbstrier@wisc.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Am J Primatol
JT  - American journal of primatology
JID - 8108949
SB  - IM
MH  - Animals
MH  - *Animals, Wild
MH  - Atelinae/*physiology
MH  - Brazil
MH  - Capacity Building/methods
MH  - Community Participation/methods
MH  - Conservation of Natural Resources/*methods
MH  - *Environment
MH  - *Ethics, Research
MH  - Humans
MH  - *Research Design
MH  - Risk Assessment/methods
EDAT- 2010/07/24 06:00
MHDA- 2010/10/29 06:00
CRDT- 2010/07/24 06:00
PHST- 2010/07/24 06:00 [entrez]
PHST- 2010/07/24 06:00 [pubmed]
PHST- 2010/10/29 06:00 [medline]
AID - 10.1002/ajp.20830 [doi]
PST - ppublish
SO  - Am J Primatol. 2010 Sep;72(9):772-8. doi: 10.1002/ajp.20830.


PMID- 20653001
OWN - NLM
STAT- MEDLINE
DCOM- 20101028
LR  - 20100723
IS  - 1098-2345 (Electronic)
IS  - 0275-2565 (Linking)
VI  - 72
IP  - 9
DP  - 2010 Sep
TI  - Field primatology of today: current ethical issues.
PG  - 749-53
LID - 10.1002/ajp.20836 [doi]
AB  - As members of professional organizations such as American Society of
      Primatologists (ASP) and the International Primatological Society (IPS),
      primatologists must adhere to a set of nonhuman primate-focused principles
      outlined in resolutions and policy statements on, for example, the ethical
      treatment of nonhuman primates. Those of us that work in the field must also
      address issues such as the protection of primate health in the wild and the
      conservation of wild primate populations. Moreover, we increasingly find
      ourselves in complex situations where we must balance human and nonhuman primate 
      needs and interests. The selection of commentary pieces in this edition of the
      American Journal of Primatology originated from presentations given in the
      symposium, Field Primatology of Today: Navigating the Ethical Landscape, held at 
      the 32nd Annual Meeting of the American Society of Primatologists (ASP) in
      September 2009. The goals of that symposium and these resulting commentary pieces
      are threefold: (1) to revive a discussion of key contemporary ethical issues
      faced by field primatologists, (2) to highlight the need for centrally placed
      ethical considerations in various facets of our professional lives, particularly 
      research and teaching, and (3) to consider what a comprehensive ethical code that
      addresses all of these issues might look like.
CI  - (c) 2010 Wiley-Liss, Inc.
FAU - MacKinnon, K C
AU  - MacKinnon KC
AD  - Department of Sociology and Criminal Justice, Saint Louis University, St. Louis, 
      MO 63108, USA. mackinn@slu.edu
FAU - Riley, E P
AU  - Riley EP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Primatol
JT  - American journal of primatology
JID - 8108949
SB  - IM
MH  - *Animal Welfare
MH  - Animals
MH  - *Animals, Wild
MH  - Conservation of Natural Resources/*methods
MH  - *Ethics, Research
MH  - *Primates
MH  - Societies, Scientific/*ethics
MH  - Zoology/*ethics
EDAT- 2010/07/24 06:00
MHDA- 2010/10/29 06:00
CRDT- 2010/07/24 06:00
PHST- 2010/07/24 06:00 [entrez]
PHST- 2010/07/24 06:00 [pubmed]
PHST- 2010/10/29 06:00 [medline]
AID - 10.1002/ajp.20836 [doi]
PST - ppublish
SO  - Am J Primatol. 2010 Sep;72(9):749-53. doi: 10.1002/ajp.20836.


PMID- 20652751
OWN - NLM
STAT- MEDLINE
DCOM- 20110128
LR  - 20220317
IS  - 1572-8633 (Electronic)
IS  - 1386-7423 (Linking)
VI  - 13
IP  - 4
DP  - 2010 Nov
TI  - Doctor-cared dying instead of physician-assisted suicide: a perspective from
      Germany.
PG  - 371-81
LID - 10.1007/s11019-010-9266-z [doi]
AB  - The current article deals with the ethics and practice of physician-assisted
      suicide (PAS) and dying. The debate about PAS must take the important legal and
      ethical context of medical acts at the end of life into consideration, and cannot
      be examined independently from physicians' duties with respect to care for the
      terminally ill and dying. The discussion in Germany about active euthanasia,
      limiting medical intervention at the end of life, patient autonomy, advanced
      directives, and PAS is not fundamentally different in content and arguments from 
      discussions led in other European countries and the United States. This must be
      emphasized, since it is occasionally claimed that in Germany a thorough
      discussion could not be held with the same openness as in other countries due to 
      Germany's recent history. Still, it is worthwhile to portray the debate, which
      has been held intensively both among experts and the German public, from the
      German perspective. In general, it can be stated that in Germany debates about
      questions of medical ethics and bioethics are taking place with relatively large 
      participation of an interested public, as shown, for instance, by the intense
      recent discussions about the legalisation of advanced directives on June 18 2009,
      the generation and use of embryonic stem cells in research or the highly
      difficult challenges for the prioritizing and rationing of scarce resources
      within the German health care system. Hence, the current article provides some
      insights into central medical and legal documents and the controversial public
      debate on the regulation of end-of-life medical care. In conclusion, euthanasia
      and PAS as practices of direct medical killing or medically assisted killing of
      vulnerable persons as "due care" is to be strictly rejected. Instead, we propose 
      a more holistically-oriented palliative concept of a compassionate and virtuous
      doctor-cared dying that is embedded in an ethics of care.
FAU - Oduncu, Fuat S
AU  - Oduncu FS
AD  - Medizinische Klinik, Campus Innenstadt, Klinikum der Universitat Munchen,
      Hamatologie und Onkologie, Ziemssenstrasse 1, 80336, Munich, Germany.
      Fuat.Oduncu@med.uni-muenchen.de
FAU - Sahm, Stephan
AU  - Sahm S
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Med Health Care Philos
JT  - Medicine, health care, and philosophy
JID - 9815900
SB  - IM
MH  - *Advance Directives
MH  - Attitude of Health Personnel
MH  - *Euthanasia, Active
MH  - Germany
MH  - Humans
MH  - *Palliative Care
MH  - *Patient Rights
MH  - Personal Autonomy
MH  - *Suicide, Assisted
EDAT- 2010/07/24 06:00
MHDA- 2011/02/01 06:00
CRDT- 2010/07/24 06:00
PHST- 2010/07/24 06:00 [entrez]
PHST- 2010/07/24 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
AID - 10.1007/s11019-010-9266-z [doi]
PST - ppublish
SO  - Med Health Care Philos. 2010 Nov;13(4):371-81. doi: 10.1007/s11019-010-9266-z.


PMID- 20652378
OWN - NLM
STAT- MEDLINE
DCOM- 20101215
LR  - 20211020
IS  - 1573-2614 (Electronic)
IS  - 1387-1307 (Linking)
VI  - 24
IP  - 4
DP  - 2010 Aug
TI  - Current status on VAP prevention: evidence-based medicine makes the ethics of
      withholding SDD questionable.
PG  - 305-6
LID - 10.1007/s10877-010-9249-x [doi]
FAU - Silvestri, L
AU  - Silvestri L
FAU - van Saene, H K F
AU  - van Saene HK
FAU - Tomasino, S
AU  - Tomasino S
FAU - Taylor, N
AU  - Taylor N
LA  - eng
PT  - Comment
PT  - Letter
DEP - 20100723
PL  - Netherlands
TA  - J Clin Monit Comput
JT  - Journal of clinical monitoring and computing
JID - 9806357
SB  - IM
CON - J Clin Monit Comput. 2010 Apr;24(2):161-8. PMID: 20237830
MH  - Decontamination/*methods
MH  - Drainage
MH  - Evidence-Based Medicine
MH  - Humans
MH  - Pneumonia, Ventilator-Associated/*prevention & control
MH  - Practice Guidelines as Topic
MH  - Withholding Treatment/*ethics
EDAT- 2010/07/24 06:00
MHDA- 2010/12/16 06:00
CRDT- 2010/07/24 06:00
PHST- 2010/07/06 00:00 [received]
PHST- 2010/07/09 00:00 [accepted]
PHST- 2010/07/24 06:00 [entrez]
PHST- 2010/07/24 06:00 [pubmed]
PHST- 2010/12/16 06:00 [medline]
AID - 10.1007/s10877-010-9249-x [doi]
PST - ppublish
SO  - J Clin Monit Comput. 2010 Aug;24(4):305-6. doi: 10.1007/s10877-010-9249-x. Epub
      2010 Jul 23.


PMID- 20652013
OWN - NLM
STAT- MEDLINE
DCOM- 20101102
LR  - 20220309
IS  - 1549-1676 (Electronic)
IS  - 1549-1277 (Linking)
VI  - 7
IP  - 7
DP  - 2010 Jul 20
TI  - A model for the roll-out of comprehensive adult male circumcision services in
      African low-income settings of high HIV incidence: the ANRS 12126 Bophelo Pele
      Project.
PG  - e1000309
LID - 10.1371/journal.pmed.1000309 [doi]
AB  - BACKGROUND: World Health Organization (WHO)/Joint United Nations Programme on
      AIDS (UNAIDS) has recommended adult male circumcision (AMC) for the prevention of
      heterosexually acquired HIV infection in men from communities where HIV is
      hyperendemic and AMC prevalence is low. The objective of this study was to
      investigate the feasibility of the roll-out of medicalized AMC according to
      UNAIDS/WHO operational guidelines in a targeted African setting. METHODS AND
      FINDINGS: The ANRS 12126 "Bophelo Pele" project was implemented in 2008 in the
      township of Orange Farm (South Africa). It became functional in 5 mo once local
      and ethical authorizations were obtained. Project activities involved community
      mobilization and outreach, as well as communication approaches aimed at both men 
      and women incorporating broader HIV prevention strategies and promoting sexual
      health. Free medicalized AMC was offered to male residents aged 15 y and over at 
      the project's main center, which had been designed for low-income settings.
      Through the establishment of an innovative surgical organization, up to 150 AMCs 
      under local anesthesia, with sterilized circumcision disposable kits and
      electrocautery, could be performed per day by three task-sharing teams of one
      medical circumciser and five nurses. Community support for the project was high. 
      As of November 2009, 14,011 men had been circumcised, averaging 740 per month in 
      the past 12 mo, and 27.5% of project participants agreed to be tested for HIV.
      The rate of adverse events, none of which resulted in permanent damage or death, 
      was 1.8%. Most of the men surveyed (92%) rated the services provided positively. 
      An estimated 39.1% of adult uncircumcised male residents have undergone surgery
      and uptake is steadily increasing. CONCLUSION: This study demonstrates that a
      quality AMC roll-out adapted to African low-income settings is feasible and can
      be implemented quickly and safely according to international guidelines. The
      project can be a model for the scale-up of comprehensive AMC services, which
      could be tailored for other rural and urban communities of high HIV prevalence
      and low AMC rates in Eastern and Southern Africa. Please see later in the article
      for the Editors' Summary.
FAU - Lissouba, Pascale
AU  - Lissouba P
AD  - INSERM U1018 Centre de Recherche en Epidemiologie et Sante des Populations
      (CESP), Villejuif, France.
FAU - Taljaard, Dirk
AU  - Taljaard D
FAU - Rech, Dino
AU  - Rech D
FAU - Doyle, Sean
AU  - Doyle S
FAU - Shabangu, Daniel
AU  - Shabangu D
FAU - Nhlapo, Cynthia
AU  - Nhlapo C
FAU - Otchere-Darko, Josephine
AU  - Otchere-Darko J
FAU - Mashigo, Thabo
AU  - Mashigo T
FAU - Matson, Caitlin
AU  - Matson C
FAU - Lewis, David
AU  - Lewis D
FAU - Billy, Scott
AU  - Billy S
FAU - Auvert, Bertran
AU  - Auvert B
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100720
PL  - United States
TA  - PLoS Med
JT  - PLoS medicine
JID - 101231360
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Africa
MH  - Circumcision, Male/*statistics & numerical data
MH  - Community-Institutional Relations
MH  - Feasibility Studies
MH  - Female
MH  - HIV Infections/epidemiology/*prevention & control/*transmission
MH  - Health Plan Implementation/economics/*methods
MH  - Heterosexuality
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - *Models, Theoretical
MH  - *Poverty/statistics & numerical data
MH  - Young Adult
PMC - PMC2907271
EDAT- 2010/07/24 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/07/24 06:00
PHST- 2010/01/06 00:00 [received]
PHST- 2010/06/09 00:00 [accepted]
PHST- 2010/07/24 06:00 [entrez]
PHST- 2010/07/24 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - 10.1371/journal.pmed.1000309 [doi]
PST - epublish
SO  - PLoS Med. 2010 Jul 20;7(7):e1000309. doi: 10.1371/journal.pmed.1000309.


PMID- 20651867
OWN - NLM
STAT- MEDLINE
DCOM- 20100921
LR  - 20101022
IS  - 1175-8716 (Electronic)
IS  - 0028-8446 (Linking)
VI  - 123
IP  - 1318
DP  - 2010 Jul 16
TI  - The student code: ethical and professional expectations of medical students at
      the University of Otago.
PG  - 43-9
AB  - Medical students at the University of Otago are now required to sign a 'student
      code' on beginning medical school. This new requirement has been put in place in 
      response to changes to the medical curriculum that have resulted in earlier and
      increased contact with patients, healthcare staff and the general public, and in 
      order to recognise and formalise the students' own learning needs. While a
      student code can most obviously be useful for disciplinary and assessment
      purposes, the authors make a claim for the code to be used as educational tool to
      assist students to internalise their obligations to others. The student code,
      while having common values espoused in other extant codes, is framed with the
      student experience in mind. The authors discuss the process of development,
      implementation and proposed review.
FAU - Anderson, Lynley C
AU  - Anderson LC
AD  - Bioethics Centre, Medical and Surgical Sciences, Dunedin School of Medicine, PO
      Box 913, Dunedin, New Zealand. lynley.anderson@otago.ac.nz
FAU - Pickering, Neil J
AU  - Pickering NJ
LA  - eng
PT  - Journal Article
DEP - 20100716
PL  - New Zealand
TA  - N Z Med J
JT  - The New Zealand medical journal
JID - 0401067
SB  - IM
MH  - *Codes of Ethics
MH  - Curriculum
MH  - Education, Medical, Undergraduate/*organization & administration
MH  - Ethics, Medical/*education
MH  - Humans
MH  - New Zealand
MH  - Physician-Patient Relations/*ethics
MH  - Students, Medical/*psychology
MH  - *Universities
EDAT- 2010/07/24 06:00
MHDA- 2010/09/23 06:00
CRDT- 2010/07/24 06:00
PHST- 2010/07/24 06:00 [entrez]
PHST- 2010/07/24 06:00 [pubmed]
PHST- 2010/09/23 06:00 [medline]
PST - epublish
SO  - N Z Med J. 2010 Jul 16;123(1318):43-9.


PMID- 20651747
OWN - NLM
STAT- MEDLINE
DCOM- 20100921
LR  - 20211020
IS  - 1474-1741 (Electronic)
IS  - 1474-1733 (Linking)
VI  - 10
IP  - 8
DP  - 2010 Aug
TI  - The changing face of rheumatoid arthritis: sustained remission for all?
PG  - 605-11
LID - 10.1038/nri2804 [doi]
AB  - Earlier diagnosis and treatment, plus biological therapies, have transformed the 
      outlook for many patients with rheumatoid arthritis. In the future, new
      biomarkers for diagnosis, prognosis and therapeutic response will further improve
      outcomes. Additionally, preclinical diagnosis and tolerogenic therapies could
      provide sustained remission for some individuals, although ethical and societal
      challenges must also be addressed before rheumatoid arthritis becomes
      'yesterday's disease'.
FAU - Isaacs, John D
AU  - Isaacs JD
AD  - Institute of Cellular Medicine, Musculoskeletal Research Group, Newcastle
      University Medical School, Framlington Place, Newcastle-upon-Tyne NE2 4HH, UK.
      j.d.isaacs@ncl.ac.uk
LA  - eng
PT  - Review
PL  - England
TA  - Nat Rev Immunol
JT  - Nature reviews. Immunology
JID - 101124169
RN  - 0 (Antirheumatic Agents)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Antirheumatic Agents/*therapeutic use
MH  - Arthritis, Rheumatoid/*diagnosis/*drug therapy
MH  - Biomarkers/analysis
MH  - Early Diagnosis
MH  - Humans
MH  - Prognosis
MH  - Remission Induction
MH  - Treatment Outcome
EDAT- 2010/07/24 06:00
MHDA- 2010/09/23 06:00
CRDT- 2010/07/24 06:00
PHST- 2010/07/24 06:00 [entrez]
PHST- 2010/07/24 06:00 [pubmed]
PHST- 2010/09/23 06:00 [medline]
AID - nri2804 [pii]
AID - 10.1038/nri2804 [doi]
PST - ppublish
SO  - Nat Rev Immunol. 2010 Aug;10(8):605-11. doi: 10.1038/nri2804.


PMID- 20650685
OWN - NLM
STAT- MEDLINE
DCOM- 20110624
LR  - 20110311
IS  - 1444-2892 (Electronic)
IS  - 1443-9506 (Linking)
VI  - 20
IP  - 3
DP  - 2011 Mar
TI  - Toward clinical application of stem cells for cardiac regeneration.
PG  - 173-9
LID - 10.1016/j.hlc.2010.06.661 [doi]
AB  - Heart failure affects more than 10% of the Australian population over age 65, and
      the ageing population will ensure continued growth of this significant problem.
      There are various treatment options available, but the growing field of
      regenerative therapy offers promise to restore or replace tissue lost in those
      with either congenital or acquired cardiac defects. Stem cells have many
      potential properties, but they need multiple discussed qualities to succeed in
      this field such as ease of harvest and multiplication, and most importantly
      minimal ethical concerns. There are multiple cell types available and one of the 
      challenges will be to find the most appropriate cell type for cardiac
      regeneration. Cardiac tissue engineering is being explored using both in vitro
      and in vivo techniques. In vitro methods are primarily limited in terms of the
      vascularisation and size of the construct. In vivo engineered constructs overcome
      these limitations in early models, but they are still not ready for human trials.
      This review aims to provide the reader with an outline of the cell-based and
      tissue engineering therapies currently being used and developed for cardiac
      regeneration, as well as some insight into the potential problems that may hamper
      its progress in the future.
CI  - Copyright (c) 2010 Australasian Society of Cardiac and Thoracic Surgeons and the 
      Cardiac Society of Australia and New Zealand. Published by Elsevier B.V. All
      rights reserved.
FAU - Stubbs, Samantha L
AU  - Stubbs SL
AD  - O'Brien Institute, Fitzroy, Victoria, Australia.
FAU - Crook, Jeremy M
AU  - Crook JM
FAU - Morrison, Wayne A
AU  - Morrison WA
FAU - Newcomb, Andrew E
AU  - Newcomb AE
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100722
PL  - Australia
TA  - Heart Lung Circ
JT  - Heart, lung & circulation
JID - 100963739
SB  - IM
MH  - Animals
MH  - Heart Diseases/*therapy
MH  - Humans
MH  - *Myocardium
MH  - *Regeneration
MH  - *Stem Cell Transplantation
MH  - *Stem Cells
MH  - *Tissue Engineering
EDAT- 2010/07/24 06:00
MHDA- 2011/06/28 06:00
CRDT- 2010/07/24 06:00
PHST- 2010/07/24 06:00 [entrez]
PHST- 2010/07/24 06:00 [pubmed]
PHST- 2011/06/28 06:00 [medline]
AID - S1443-9506(10)00974-1 [pii]
AID - 10.1016/j.hlc.2010.06.661 [doi]
PST - ppublish
SO  - Heart Lung Circ. 2011 Mar;20(3):173-9. doi: 10.1016/j.hlc.2010.06.661. Epub 2010 
      Jul 22.


PMID- 20650557
OWN - NLM
STAT- MEDLINE
DCOM- 20110921
LR  - 20110613
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 72
IP  - 11
DP  - 2011 Jun
TI  - Unambiguous test results or individual independence? The role of clients and
      families in predictive BRCA-testing in the Netherlands compared to the USA.
PG  - 1793-801
LID - 10.1016/j.socscimed.2010.06.011 [doi]
AB  - It has been frequently acknowledged that results of predictive genetic tests may 
      have implications for relatives as well as for the individual client. Ethicists
      have noted that an individual's right to know her genetic risk may conflict with 
      a relative's right not to know this risk. It is hardly recognised, however, that 
      family members may have a role in the production of test results as well. This
      article reconstructs the actual process of predictive BRCA-testing in the
      Netherlands, with a special focus on the roles assigned to clients and families
      and the expectations about family relationships inscribed in this practice.
      Fieldwork was carried out in an outpatient clinic for clinical genetics in an
      academic hospital. Data collection included 11 interviews with members of
      families, observations of counselling interviews between research participants
      and their clinical geneticist, and interviews with the 2 clinical geneticists
      involved in the consultations. It compares this process to the American practice 
      of BRCA-testing. Whereas Dutch practice presupposes active involvement of
      diseased relatives in the testing process, American practice constitutes the
      client primarily as an independent individual who may or may not decide to
      involve her relatives. Moreover, Dutch clients are expected to have a harmonious,
      open and communicative relationship with their relatives. The American client, in
      contrast, is supposed to have more distant family relationships. It is argued
      that an interpretation of these differences in terms of 'the right to know' and
      'the right not to know' misses the point, because the production of informative
      test results depends on the cooperation of relatives. The differences between
      Dutch and American practice are more adequately interpreted as implying a
      preference for unambiguous test results versus a preference for individual
      independence. The paper shows what is lost when opting for one value at the cost 
      of another and discusses several alternatives to circumvent the value conflict at
      stake. By opening up for discussion the values implicit in BRCA-testing
      practices, the paper aims to contribute to debates on the overall desirability of
      these practices.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Boenink, Marianne
AU  - Boenink M
AD  - University of Twente, Faculty of Behavioural Science, Department of Philosophy,
      Enschede, Netherlands. m.boenink@utwente.nl
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20100625
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Breast Neoplasms/genetics
MH  - *Cross-Cultural Comparison
MH  - *Family Relations
MH  - Female
MH  - Genes, BRCA1
MH  - Genes, BRCA2
MH  - Genetic Testing/*psychology
MH  - Humans
MH  - Netherlands
MH  - Ovarian Neoplasms/genetics
MH  - *Personal Autonomy
MH  - Qualitative Research
MH  - *Social Values
MH  - United States
EDAT- 2010/07/24 06:00
MHDA- 2011/09/22 06:00
CRDT- 2010/07/24 06:00
PHST- 2009/02/13 00:00 [received]
PHST- 2010/05/01 00:00 [revised]
PHST- 2010/06/15 00:00 [accepted]
PHST- 2010/07/24 06:00 [entrez]
PHST- 2010/07/24 06:00 [pubmed]
PHST- 2011/09/22 06:00 [medline]
AID - S0277-9536(10)00477-6 [pii]
AID - 10.1016/j.socscimed.2010.06.011 [doi]
PST - ppublish
SO  - Soc Sci Med. 2011 Jun;72(11):1793-801. doi: 10.1016/j.socscimed.2010.06.011. Epub
      2010 Jun 25.


PMID- 20650332
OWN - NLM
STAT- MEDLINE
DCOM- 20110408
LR  - 20211020
IS  - 1556-3871 (Electronic)
IS  - 1547-5271 (Linking)
VI  - 7
IP  - 11
DP  - 2010 Nov
TI  - Ethical and legal views of physicians regarding deactivation of cardiac
      implantable electrical devices: a quantitative assessment.
PG  - 1537-42
LID - 10.1016/j.hrthm.2010.07.018 [doi]
AB  - BACKGROUND: Despite the high prevalence of pacemakers and implantable
      cardioverter-defibrillators, little is known about physicians' views surrounding 
      the ethical and legal aspects of managing these devices at the end of life.
      OBJECTIVE: The purpose of this study was to identify physicians' experiences and 
      views surrounding the ethical and legal aspects of managing cardiac devices at
      the end of life. METHODS: Survey questions were administered to internal medicine
      physicians and subspecialists at a tertiary care center. Physicians were surveyed
      about their clinical experience, legal knowledge, and ethical beliefs relating to
      the withdrawal of PM and ICD therapy in comparison to other life-sustaining
      therapies. RESULTS: Responses were obtained from 185 physicians. Compared to
      withdrawal of PMs and ICDs, physicians more often reported having participated in
      the withdrawal or removal of mechanical ventilation (86.1% vs 33.9%, P <.0001),
      dialysis (60.6% vs 33.9%, P <.001), and feeding tubes (73.8% vs 33.9%, P <.0001).
      Physicians were consistently less comfortable discussing cessation of PMs and
      ICDs compared to other life-sustaining therapies (P <.005). Only 65% of
      physicians correctly identified the legal status of euthanasia in the United
      States, and 20% accurately reported the legal status of physician-assisted
      suicide in the United States. Compared to deactivation of an ICD, physicians more
      often characterized deactivation of a PM in a pacemaker-dependent patient as
      physician-assisted suicide (19% vs 10%, P = .027) or euthanasia (9% vs 1%, P
      <.001). CONCLUSION: In this single-center study, internists were less comfortable
      discussing cessation of PM and ICD therapy compared to other life-sustaining
      therapies and lacked experience with this practice. Education regarding the legal
      and ethical parameters of device deactivation is needed.
CI  - Copyright (c) 2010 Heart Rhythm Society. Published by Elsevier Inc. All rights
      reserved.
FAU - Kramer, Daniel B
AU  - Kramer DB
AD  - CardioVascular Institute, Beth Israel Deaconess Medical Center and Harvard
      Medical School, Boston, Massachusetts 02446, USA. dkramer@bidmc.harvard.edu
FAU - Kesselheim, Aaron S
AU  - Kesselheim AS
FAU - Brock, Dan W
AU  - Brock DW
FAU - Maisel, William H
AU  - Maisel WH
LA  - eng
GR  - K08 HS018465/HS/AHRQ HHS/United States
GR  - UL1 RR025758/RR/NCRR NIH HHS/United States
GR  - 1-UL1-RR025758-02/RR/NCRR NIH HHS/United States
GR  - K08HS18465-01/HS/AHRQ HHS/United States
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20100719
PL  - United States
TA  - Heart Rhythm
JT  - Heart rhythm
JID - 101200317
SB  - IM
CIN - Heart Rhythm. 2010 Nov;7(11):1543-4. PMID: 20816871
MH  - Adult
MH  - Aged
MH  - *Attitude of Health Personnel
MH  - Decision Making
MH  - Defibrillators, Implantable/*ethics
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pacemaker, Artificial/*ethics
MH  - *Physician's Role
MH  - Terminal Care
MH  - Withholding Treatment
MH  - Young Adult
PMC - PMC3001282
MID - NIHMS243099
EDAT- 2010/07/24 06:00
MHDA- 2011/04/09 06:00
CRDT- 2010/07/24 06:00
PHST- 2010/05/20 00:00 [received]
PHST- 2010/07/13 00:00 [accepted]
PHST- 2010/07/24 06:00 [entrez]
PHST- 2010/07/24 06:00 [pubmed]
PHST- 2011/04/09 06:00 [medline]
AID - S1547-5271(10)00709-5 [pii]
AID - 10.1016/j.hrthm.2010.07.018 [doi]
PST - ppublish
SO  - Heart Rhythm. 2010 Nov;7(11):1537-42. doi: 10.1016/j.hrthm.2010.07.018. Epub 2010
      Jul 19.


PMID- 20649949
OWN - NLM
STAT- MEDLINE
DCOM- 20101022
LR  - 20211020
IS  - 1471-2156 (Electronic)
IS  - 1471-2156 (Linking)
VI  - 11
DP  - 2010 Jul 22
TI  - A genetic dissection of breed composition and performance enhancement in the
      Alaskan sled dog.
PG  - 71
LID - 10.1186/1471-2156-11-71 [doi]
AB  - BACKGROUND: The Alaskan sled dog offers a rare opportunity to investigate the
      development of a dog breed based solely on performance, rather than appearance,
      thus setting the breed apart from most others. Several established breeds, many
      of which are recognized by the American Kennel Club (AKC), have been introduced
      into the sled dog population to enhance racing performance. We have used
      molecular methods to ascertain the constitutive breeds used to develop successful
      sled dog lines, and in doing so, determined the breed origins of specific
      performance-related behaviors.One hundred and ninety-nine Alaskan sled dogs were 
      genotyped using 96 microsatellite markers that span the canine genome. These data
      were compared to that from 141 similarly genotyped purebred dog breeds. Sled dogs
      were evaluated for breed composition based on a variety of performance phenotypes
      including speed, endurance and work ethic, and the data stratified based on
      population structure. RESULTS: We observe that the Alaskan sled dog has a unique 
      molecular signature and that the genetic profile is sufficient for identifying
      dogs bred for sprint versus distance. When evaluating contributions of existing
      breeds we find that the Alaskan Malamute and Siberian Husky contributions are
      associated with enhanced endurance; Pointer and Saluki are associated with
      enhanced speed and the Anatolian Shepherd demonstrates a positive influence on
      work ethic. CONCLUSION: We have established a genetic breed profile for the
      Alaskan sled dog, identified profile variance between sprint and distance dogs,
      and established breeds associated with enhanced performance attributes. These
      data set the stage for mapping studies aimed at finding genes that are associated
      with athletic attributes integral to the high performing Alaskan sled dog.
FAU - Huson, Heather J
AU  - Huson HJ
AD  - Cancer Genetics Branch, National Human Genome Research Institute, National
      Institutes of Health, Bethesda, Maryland 20892, USA.
FAU - Parker, Heidi G
AU  - Parker HG
FAU - Runstadler, Jonathan
AU  - Runstadler J
FAU - Ostrander, Elaine A
AU  - Ostrander EA
LA  - eng
GR  - 5P20RR016466/RR/NCRR NIH HHS/United States
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
DEP - 20100722
PL  - England
TA  - BMC Genet
JT  - BMC genetics
JID - 100966978
SB  - IM
MH  - Animals
MH  - *Breeding
MH  - Dogs/*genetics
MH  - Genotype
MH  - *Microsatellite Repeats
MH  - Phenotype
MH  - Physical Endurance/genetics
MH  - Running
PMC - PMC2920855
EDAT- 2010/07/24 06:00
MHDA- 2010/10/23 06:00
CRDT- 2010/07/24 06:00
PHST- 2010/04/07 00:00 [received]
PHST- 2010/07/22 00:00 [accepted]
PHST- 2010/07/24 06:00 [entrez]
PHST- 2010/07/24 06:00 [pubmed]
PHST- 2010/10/23 06:00 [medline]
AID - 1471-2156-11-71 [pii]
AID - 10.1186/1471-2156-11-71 [doi]
PST - epublish
SO  - BMC Genet. 2010 Jul 22;11:71. doi: 10.1186/1471-2156-11-71.


PMID- 20649669
OWN - NLM
STAT- MEDLINE
DCOM- 20101108
LR  - 20151119
IS  - 1440-172X (Electronic)
IS  - 1322-7114 (Linking)
VI  - 16
IP  - 4
DP  - 2010 Aug
TI  - Adverse events in Jordanian hospitals: types and causes.
PG  - 374-80
LID - 10.1111/j.1440-172X.2010.01854.x [doi]
AB  - Adverse events in health care have become an important issue for health-care
      professionals, administrators, health policy-makers, public and patients.
      Literature on adverse events in Jordan is scarce. The purpose of the study was
      (i) to identify the common types and major causes of adverse events in Jordanian 
      hospitals from the nurses' perspective; and (ii) to estimate the frequency of
      adverse events in Jordanian hospitals. Qualitative and quantitative data
      regarding the perceived types, causes and incidence of adverse events were
      collected using a web-based questionnaire. A total of 75 valid responses with
      qualitative and quantitative data were obtained. The results indicated (i) that
      medication errors, wrong diagnosis, hospital acquired infections, bed sores and
      falls were the most common types of adverse events; and (ii) that workload and
      inadequate staffing, technical performance, negligence and poor ethics, poor
      management, psychosocial job demands and written guidelines were the most common 
      causes of adverse events. On average, participants in the study believed that
      adverse events occurred in about 28% of all hospital admissions. Nurse and
      hospital administrators and health policy-makers should develop and institute
      effective strategies and policies to prevent or minimize the occurrence of
      adverse events.
FAU - Hayajneh, Yaseen A
AU  - Hayajneh YA
AD  - College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.
FAU - AbuAlRub, Raeda F
AU  - AbuAlRub RF
FAU - Almakhzoomy, Ibtihal K
AU  - Almakhzoomy IK
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Int J Nurs Pract
JT  - International journal of nursing practice
JID - 9613615
MH  - Humans
MH  - Incidence
MH  - Internet
MH  - Jordan
MH  - Medical Errors/classification/*statistics & numerical data
MH  - Surveys and Questionnaires
EDAT- 2010/07/24 06:00
MHDA- 2010/11/09 06:00
CRDT- 2010/07/24 06:00
PHST- 2010/07/24 06:00 [entrez]
PHST- 2010/07/24 06:00 [pubmed]
PHST- 2010/11/09 06:00 [medline]
AID - IJN1854 [pii]
AID - 10.1111/j.1440-172X.2010.01854.x [doi]
PST - ppublish
SO  - Int J Nurs Pract. 2010 Aug;16(4):374-80. doi: 10.1111/j.1440-172X.2010.01854.x.


PMID- 20649440
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20131121
IS  - 1557-8674 (Electronic)
IS  - 1096-2964 (Linking)
VI  - 11
IP  - 5
DP  - 2010 Oct
TI  - Analysis of plasma citrulline and intestinal morphometry in mice with
      hepatosplenic schistosomiasis.
PG  - 419-26
LID - 10.1089/sur.2009.066 [doi]
AB  - BACKGROUND: Portal hypertension in the mucosa of the intestine and the presence
      of granulomas in the wall of this organ can alter digestive function in patients 
      with schistosomiasis. Citrulline is a potential marker of intestinal function in 
      some diseases that affect the morphometry of the mucosa because of its close
      association with enterocytes. The aims of the present study were to determine
      serum citrulline concentrations in mice with hepatosplenic schistosomiasis,
      analyze the morphologic repercussions for the mucosa of the small intestine,
      correlate citrulline concentrations with morphometric changes in the intestinal
      mucosa, and evaluate the effect of splenectomy on citrulline concentration.
      METHODS: After approval from the local ethics committee, 46 adult female albino
      Swiss mice were divided into two groups: Control (23 healthy mice) and
      experimental (23 mice with hepatosplenic schistosomiasis). Blood samples were
      collected for the analysis of plasma citrulline before and after splenectomy. A
      segment of the jejunum was resected for morphometric analysis. RESULTS: The
      average body mass in the control group was greater than that in the experimental 
      group (p = 0.00062). The average citrulline concentration in the control group
      was greater than that in the experimental group both before and after splenectomy
      (p < 0.001). In the experimental group, the villi had less height and area, and
      there was a smaller perimeter of the mucosal surface (p = 0.003, <0.001, and p = 
      0.001, respectively). There was a direct correlation between citrulline
      concentration and the height and area of the villi (p = 0.003 and 0.04,
      respectively). There was no correlation between citrulline concentration and the 
      perimeter of the surface of the jejunal mucosa. After splenectomy, there was a
      reduction in the mean citrulline concentration in the experimental group (p =
      0.009). CONCLUSIONS: Serum citrulline concentrations were reduced in mice with
      schistosomiasis, and a direct correlation was found between the citrulline
      concentration and the morphometry of the jejunal villi. Moreover, there was a
      reduction in the plasma concentration of citrulline after splenectomy.
FAU - Siqueira, Luciana T
AU  - Siqueira LT
AD  - General Surgery Service, University Hospital of the Universidade Federal de
      Pernambuco, Recife, Brazil. lt-siqueira@uol.com.br
FAU - Ferraz, Alvaro Antonio B
AU  - Ferraz AA
FAU - Campos, Josemberg M
AU  - Campos JM
FAU - De Lima Filho, Jose Luiz
AU  - De Lima Filho JL
FAU - Albuquerque, Monica C P A
AU  - Albuquerque MC
FAU - de Lima Aires, Andre
AU  - de Lima Aires A
FAU - Ribeiro, Maria Helena M Lima
AU  - Ribeiro MH
FAU - Cavalcanti, Maria Taciana H
AU  - Cavalcanti MT
FAU - De Lima B Cavalcanti, Carmelita
AU  - De Lima B Cavalcanti C
FAU - Ferraz, Edmundo Machado
AU  - Ferraz EM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Surg Infect (Larchmt)
JT  - Surgical infections
JID - 9815642
RN  - 29VT07BGDA (Citrulline)
SB  - IM
MH  - Animals
MH  - Body Weight
MH  - Citrulline/*blood
MH  - Disease Models, Animal
MH  - Female
MH  - Histocytochemistry
MH  - Intestinal Mucosa/pathology
MH  - Jejunum/*pathology
MH  - Liver Diseases/*parasitology/pathology
MH  - Mice
MH  - Microscopy
MH  - Plasma/chemistry
MH  - Schistosomiasis/*pathology/surgery
MH  - Splenectomy
MH  - Splenic Diseases/*parasitology/pathology/surgery
EDAT- 2010/07/24 06:00
MHDA- 2011/01/07 06:00
CRDT- 2010/07/24 06:00
PHST- 2010/07/24 06:00 [entrez]
PHST- 2010/07/24 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
AID - 10.1089/sur.2009.066 [doi]
PST - ppublish
SO  - Surg Infect (Larchmt). 2010 Oct;11(5):419-26. doi: 10.1089/sur.2009.066.


PMID- 20649169
OWN - NLM
STAT- MEDLINE
DCOM- 20100819
LR  - 20100723
IS  - 0883-5381 (Print)
IS  - 0883-5381 (Linking)
VI  - 25
IP  - 4
DP  - 2010 Jul-Aug
TI  - The ethical basis for creating ACOs. Organizations have a moral imperative to
      deliver cost-effective, high-quality and safe healthcare.
PG  - 44, 46-7
FAU - Nelson, William A
AU  - Nelson WA
AD  - Dartmouth Medical School , Hanover, NH, USA. william.a.nelson@dartmouth.edu
FAU - Wadsworth, Eric
AU  - Wadsworth E
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Healthc Exec
JT  - Healthcare executive
JID - 8612808
MH  - Efficiency, Organizational/*economics
MH  - Health Facilities/*ethics
MH  - *Quality of Health Care
MH  - *Safety
MH  - *Social Responsibility
MH  - United States
EDAT- 2010/07/24 06:00
MHDA- 2010/08/20 06:00
CRDT- 2010/07/24 06:00
PHST- 2010/07/24 06:00 [entrez]
PHST- 2010/07/24 06:00 [pubmed]
PHST- 2010/08/20 06:00 [medline]
PST - ppublish
SO  - Healthc Exec. 2010 Jul-Aug;25(4):44, 46-7.


PMID- 20648532
OWN - NLM
STAT- MEDLINE
DCOM- 20101122
LR  - 20100810
IS  - 1099-0798 (Electronic)
IS  - 0735-3936 (Linking)
VI  - 28
IP  - 4
DP  - 2010 Jul-Aug
TI  - Drafting the parenting evaluation court order: a conceptual and practical
      approach.
PG  - 480-91
LID - 10.1002/bsl.947 [doi]
AB  - A court's order begins and directs the process of a court-appointed parenting
      evaluation. If the order is ill-defined, the evaluation, its conclusions, and the
      resulting expert opinion may be compromised. To draft a clear order, lawyers
      should understand the nature of a psychological evaluation, identify the legal
      bases and the authority in psychological literature and ethics for conducting a
      parenting evaluation, and establish the specific purposes for the court-ordered
      evaluation. Likewise, psychologists should understand these drafting issues to
      guard against role and ethical pitfalls in their court-appointed tasks. This
      paper will explore these issues. In addition, suggestions for drafting a motion
      petitioning the court for an evaluation are offered, and a model court order for 
      parenting evaluations is presented.
CI  - Copyright 2010 John Wiley & Sons, Ltd.
FAU - Zervopoulos, John A
AU  - Zervopoulos JA
AD  - PsychologyLaw Partners, 5440 Harvest Hill Rd, Suite 210, Dallas, TX 75230, USA.
      jzerv@psychologylawpartners.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Behav Sci Law
JT  - Behavioral sciences & the law
JID - 8404861
SB  - IM
MH  - Expert Testimony/*legislation & jurisprudence
MH  - Humans
MH  - *Interview, Psychological
MH  - *Judicial Role
MH  - Parenting/*psychology
EDAT- 2010/07/22 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/07/22 06:00
PHST- 2010/07/22 06:00 [entrez]
PHST- 2010/07/22 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1002/bsl.947 [doi]
PST - ppublish
SO  - Behav Sci Law. 2010 Jul-Aug;28(4):480-91. doi: 10.1002/bsl.947.


PMID- 20648410
OWN - NLM
STAT- MEDLINE
DCOM- 20100916
LR  - 20181201
IS  - 1439-4413 (Electronic)
IS  - 0012-0472 (Linking)
VI  - 135
IP  - 30
DP  - 2010 Jul
TI  - [Is there health care rationing in German hospitals? How exactly do we know and
      why should it not be the most important question?].
PG  - 1498-502
LID - 10.1055/s-0030-1262439 [doi]
AB  - A questionnaire study, conducted by the authors among a representative sample of 
      hospital doctors in Germany, showed that health care rationing in German
      hospitals is already a fact. But since the results were published in 2009 the
      validity of its findings has been questioned. This article provides empirical
      data to demonstrate that the findings are not biased to any significant extent by
      misunderstandings or political motivation of the responding doctors. There is
      thus an urgent need for action in support of medical professionals to make it
      possible for them to deal with implicit rationing and with the potential
      disadvantages to which vulnerable groups of patients may be exposed. Taking into 
      account health opportunity costs, increased funding in the health sector should
      not be the primary demand. The availability and critical appraisal of scientific 
      evidence on the risk/benefit ratio of medical interventions must first be
      improved in order to optimize the administration of scarce health care resources 
      in a medically rational way so that it is ethically and legally acceptable as
      well as economically reasonable.
CI  - Georg Thieme Verlag KG Stuttgart, New York.
FAU - Strech, D
AU  - Strech D
AD  - Institut fur Geschichte, Ethik und Philosophie der Medizin, Medizinische
      Hochschule Hannover, 30625 Hannover. estrech.daniel@mh-hannover.de
FAU - Marckmann, G
AU  - Marckmann G
LA  - ger
PT  - Journal Article
TT  - Wird in deutschen Kliniken rationiert oder nicht? Wie genau wir es wissen und
      warum es nicht die wichtigste Frage sein sollte.
DEP - 20100720
PL  - Germany
TA  - Dtsch Med Wochenschr
JT  - Deutsche medizinische Wochenschrift (1946)
JID - 0006723
SB  - IM
MH  - Germany/epidemiology
MH  - Health Care Rationing/*statistics & numerical data
MH  - Hospitalization/*statistics & numerical data
MH  - Humans
MH  - Physicians/*statistics & numerical data
MH  - Surveys and Questionnaires
EDAT- 2010/07/22 06:00
MHDA- 2010/09/18 06:00
CRDT- 2010/07/22 06:00
PHST- 2010/07/22 06:00 [entrez]
PHST- 2010/07/22 06:00 [pubmed]
PHST- 2010/09/18 06:00 [medline]
AID - 10.1055/s-0030-1262439 [doi]
PST - ppublish
SO  - Dtsch Med Wochenschr. 2010 Jul;135(30):1498-502. doi: 10.1055/s-0030-1262439.
      Epub 2010 Jul 20.


PMID- 20648198
OWN - NLM
STAT- MEDLINE
DCOM- 20110314
LR  - 20110706
IS  - 2150-1149 (Electronic)
IS  - 1533-3159 (Linking)
VI  - 13
IP  - 4
DP  - 2010 Jul-Aug
TI  - Pain assessment: subjectivity, objectivity, and the use of neurotechnology.
PG  - 305-15
AB  - The pain clinician is confronted with the formidable task of objectifying the
      subjective phenomenon of pain so as to determine the right treatments for both
      the pain syndrome and the patient in whom the pathology is expressed. However,
      the experience of pain - and its expression - remains enigmatic. Can currently
      available evaluative tools, questionnaires, and scales actually provide
      adequately objective information about the experiential dimensions of pain? Can, 
      or will, current and future iterations of biotechnology - whether used singularly
      or in combination (with other technologies as well as observational-behavioral
      methods) - afford objective validation of pain? And what of the clinical,
      ethical, legal and social issues that arise in and from the use - and potential
      misuse - of these approaches? Subsequent trajectories of clinical care depend
      upon the findings gained through the use of these techniques and their
      inappropriate employment - or misinterpretation of the results they provide - can
      lead to misdiagnoses and incorrect treatment. This essay is the first of a
      two-part series that explicates how the intellectual tasks of knowing about pain 
      and the assessment of its experience and expression in the pain patient are
      constituent to the moral responsibility of pain medicine. Herein, we discuss the 
      problem of pain and its expression, and those methods, techniques, and
      technologies available to bridge the gap between subjective experience and
      objective evaluation. We address how these assessment approaches are fundamental 
      to apprehend both pain as an objective, neurological event, and its impact upon
      the subjective experience, existence, and expectations of the person in pain. In 
      this way, we argue that the right use of technology - together with
      inter-subjectivity, compassion, and insight - can sustain the good of pain care
      as both a therapeutic and moral enterprise.
FAU - Giordano, James
AU  - Giordano J
AD  - Center for Neurotechnology Studies, Potomac Institute for Policy Studies,
      Arlington, VA 22203, USA. jgiordano@potomacinstitute.org
FAU - Abramson, Kim
AU  - Abramson K
FAU - Boswell, Mark V
AU  - Boswell MV
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Pain Physician
JT  - Pain physician
JID - 100954394
SB  - IM
MH  - Biotechnology/ethics/methods/trends
MH  - Diagnostic Errors/prevention & control
MH  - Diagnostic Techniques, Neurological/*ethics/*trends
MH  - Humans
MH  - Pain/diagnosis/physiopathology/psychology
MH  - Pain Measurement/*ethics/methods/*trends
MH  - Physician-Patient Relations/ethics
EDAT- 2010/07/22 06:00
MHDA- 2011/03/15 06:00
CRDT- 2010/07/22 06:00
PHST- 2010/07/22 06:00 [entrez]
PHST- 2010/07/22 06:00 [pubmed]
PHST- 2011/03/15 06:00 [medline]
PST - ppublish
SO  - Pain Physician. 2010 Jul-Aug;13(4):305-15.


PMID- 20646718
OWN - NLM
STAT- MEDLINE
DCOM- 20110408
LR  - 20141120
IS  - 1097-685X (Electronic)
IS  - 0022-5223 (Linking)
VI  - 141
IP  - 3
DP  - 2011 Mar
TI  - Short-term and long-term results of cardiac surgery in elderly and very elderly
      patients.
PG  - 725-31, 731.e1
LID - 10.1016/j.jtcvs.2010.05.010 [doi]
AB  - OBJECTIVE: Cardiac operations in elderly patients are increasingly frequent and
      imply major clinical, ethical, and economic issues. Operative and 5-year results 
      of cardiac operations in patients aged 79 years or more are known in limited
      series, and a debate is ongoing on the appropriateness of selection of patients
      for surgery. METHODS: We retrospectively reviewed our experience in 6802 patients
      aged 79 years or more who had received a cardiac operation. Surgical candidates
      were selected according to functional status, crude operative risk, and social
      context and were managed according to a multimodality protocol. RESULTS: Mean age
      was 82 years and surgery was nonelective in 1613 cases (23.5%, 31 salvage).
      Procedures consisted of valve replacement (aortic, 2817; mitral, 532; and
      tricuspid, 2 cases), valve repair (aortic, 66; mitral, 532; and tricuspid, 232
      cases), coronary bypass grafting (12,034 coronary vessels bypassed), and
      replacement of the thoracic aorta (ascending, 315; arch, 28 cases). Overall
      operative mortality was 3.4%. Nonelective presentation, need for aortic
      counterpulsation, cardiopulmonary bypass time, blood transfusion, depressed
      systolic function, and chronic lung disease predicted operative mortality.
      Five-year cumulative mortality was 7.5%. Poor systolic function, previous
      myocardial infarction, and combined coronary/mitral surgery predicted late
      mortality. The operative risk of nonagenarians operated on electively did not
      differ from that of risk-matched octogenarians. CONCLUSIONS: Cardiac surgery in
      elderly and very elderly patients can be performed with acceptable mortality
      provided that accurate selection and a multifactorial risk evaluation are
      adopted. Whenever possible, nonelective operations should be avoided and earlier 
      surgery should be encouraged. Five-year survival and functional recovery are
      good.
CI  - Copyright (c) 2011 The American Association for Thoracic Surgery. Published by
      Mosby, Inc. All rights reserved.
FAU - Speziale, Giuseppe
AU  - Speziale G
AD  - Cardiac Surgery Department of GVM Hospitals of Care and Research, Bari, Italy.
FAU - Nasso, Giuseppe
AU  - Nasso G
FAU - Barattoni, Maria Cristina
AU  - Barattoni MC
FAU - Esposito, Giampiero
AU  - Esposito G
FAU - Popoff, Georges
AU  - Popoff G
FAU - Argano, Vincenzo
AU  - Argano V
FAU - Greco, Ernesto
AU  - Greco E
FAU - Scorcin, Marcio
AU  - Scorcin M
FAU - Zussa, Claudio
AU  - Zussa C
FAU - Cristell, Donald
AU  - Cristell D
FAU - Coppola, Roberto
AU  - Coppola R
FAU - Chierchia, Sergio
AU  - Chierchia S
FAU - Marchese, Alfredo
AU  - Marchese A
FAU - Caldarola, Pasquale
AU  - Caldarola P
FAU - Fattouch, Khalil
AU  - Fattouch K
FAU - Tavazzi, Luigi
AU  - Tavazzi L
LA  - eng
PT  - Journal Article
DEP - 20100619
PL  - United States
TA  - J Thorac Cardiovasc Surg
JT  - The Journal of thoracic and cardiovascular surgery
JID - 0376343
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - *Cardiac Surgical Procedures/adverse effects/mortality
MH  - Elective Surgical Procedures
MH  - Female
MH  - Hospital Mortality
MH  - Humans
MH  - Italy
MH  - Kaplan-Meier Estimate
MH  - Logistic Models
MH  - Male
MH  - Patient Selection
MH  - Proportional Hazards Models
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Survival Rate
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2010/07/22 06:00
MHDA- 2011/04/09 06:00
CRDT- 2010/07/22 06:00
PHST- 2010/02/24 00:00 [received]
PHST- 2010/04/07 00:00 [revised]
PHST- 2010/05/17 00:00 [accepted]
PHST- 2010/07/22 06:00 [entrez]
PHST- 2010/07/22 06:00 [pubmed]
PHST- 2011/04/09 06:00 [medline]
AID - S0022-5223(10)00477-0 [pii]
AID - 10.1016/j.jtcvs.2010.05.010 [doi]
PST - ppublish
SO  - J Thorac Cardiovasc Surg. 2011 Mar;141(3):725-31, 731.e1. doi:
      10.1016/j.jtcvs.2010.05.010. Epub 2010 Jun 19.


PMID- 20646282
OWN - NLM
STAT- MEDLINE
DCOM- 20101020
LR  - 20211020
IS  - 1475-2891 (Electronic)
IS  - 1475-2891 (Linking)
VI  - 9
DP  - 2010 Jul 20
TI  - Validity of claims made in weight management research: a narrative review of
      dietetic articles.
PG  - 30
LID - 10.1186/1475-2891-9-30 [doi]
AB  - BACKGROUND: The best available evidence demonstrates that conventional weight
      management has a high long-term failure rate. The ethical implications of
      continued reliance on an energy deficit approach to weight management are
      under-explored. METHODS: A narrative literature review of journal articles in The
      Journal of Human Nutrition and Dietetics from 2004 to 2008. RESULTS: Although the
      energy deficit approach to weight management has a high long-term failure rate it
      continues to dominate research in the field. In the current research agenda,
      controversies and complexities in the evidence base are inadequately discussed,
      and claims about the likely success of weight management misrepresent available
      evidence. CONCLUSIONS: Dietetic literature on weight management fails to meet the
      standards of evidence based medicine. Research in the field is characterised by
      speculative claims that fail to accurately represent the available data. There is
      a corresponding lack of debate on the ethical implications of continuing to
      promote ineffective treatment regimes and little research into alternative
      non-weight centred approaches. An alternative health at every size approach is
      recommended.
FAU - Aphramor, Lucy
AU  - Aphramor L
AD  - Applied Research Centre in Health & Lifestyle Interventions, Faculty of Health & 
      Life Sciences, Coventry University, Coventry, CV1 5FB, UK. aa0059@coventry.ac.uk
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100720
PL  - England
TA  - Nutr J
JT  - Nutrition journal
JID - 101152213
SB  - IM
MH  - *Body Weight
MH  - Diabetes Mellitus/prevention & control
MH  - Diet, Reducing/adverse effects/*standards
MH  - Dietetics/*standards
MH  - Energy Intake
MH  - Evidence-Based Medicine
MH  - Humans
MH  - Obesity/complications/*diet therapy
PMC - PMC2916886
EDAT- 2010/07/22 06:00
MHDA- 2010/10/21 06:00
CRDT- 2010/07/22 06:00
PHST- 2010/01/29 00:00 [received]
PHST- 2010/07/20 00:00 [accepted]
PHST- 2010/07/22 06:00 [entrez]
PHST- 2010/07/22 06:00 [pubmed]
PHST- 2010/10/21 06:00 [medline]
AID - 1475-2891-9-30 [pii]
AID - 10.1186/1475-2891-9-30 [doi]
PST - epublish
SO  - Nutr J. 2010 Jul 20;9:30. doi: 10.1186/1475-2891-9-30.


PMID- 20646105
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20220408
IS  - 1532-5415 (Electronic)
IS  - 0002-8614 (Linking)
VI  - 58
IP  - 8
DP  - 2010 Aug
TI  - In situ monitoring of health in older adults: technologies and issues.
PG  - 1579-86
LID - 10.1111/j.1532-5415.2010.02959.x [doi]
AB  - With the upcoming reform of the healthcare system and the greater emphasis on
      care in the home and other living environments, geriatric providers will need
      alternate ways of monitoring disease, activity, response to therapy, and patient 
      safety. Current understanding of the dynamic nature of chronic illnesses, their
      effects on health over time, and the ability to manage them in the community are 
      limited to measuring a set of variables at discrete points in time, which does
      not account for the dynamic interactions between physiological systems and the
      environments of daily life. Recent developments of sensors, data recorders, and
      communication networks allow the unprecedented measurements of physiological and 
      sociological data for use in geriatrics care. This article identifies and
      discusses the important issues regarding the use of monitoring technologies in
      elderly patients. The goals are fourfold. First, some emerging technology that
      may improve the lives of older adults and improve care are highlighted. Second,
      the possible applications of technology in geriatrics settings are discussed,
      with a focus on acute falls, dementia, and cardiac conditions. Third, real and
      perceived concerns in using monitoring technology are identified and addressed,
      including technology adoption by elderly people; stigma; and the reduction in
      social contact; ethical concerns of privacy, autonomy, and consent; concerns of
      clinicians, including information overload, licensure, and liability; current
      reimbursement schemes for using technology; and the reliability and
      infrastructure needed for monitoring technology. Fourth, future approaches to
      make monitoring technology useful and available in geriatrics are recommended.
CI  - (c) 2010, Copyright the Authors. Journal compilation (c) 2010, The American
      Geriatrics Society.
FAU - Kang, Hyun Gu
AU  - Kang HG
AD  - Kinesiology and Health Promotion, California State Polytechnic University,
      Pomona, California 91768, USA. hgkang@csupomona.edu
FAU - Mahoney, Diane F
AU  - Mahoney DF
FAU - Hoenig, Helen
AU  - Hoenig H
FAU - Hirth, Victor A
AU  - Hirth VA
FAU - Bonato, Paolo
AU  - Bonato P
FAU - Hajjar, Ihab
AU  - Hajjar I
FAU - Lipsitz, Lewis A
AU  - Lipsitz LA
CN  - Center for Integration of Medicine and Innovative Technology Working Group on
      Advanced Approaches to Physiologic Monitoring for the Aged
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20100714
PL  - United States
TA  - J Am Geriatr Soc
JT  - Journal of the American Geriatrics Society
JID - 7503062
SB  - IM
MH  - Accidental Falls/prevention & control
MH  - Aged
MH  - Computer Communication Networks
MH  - Confidentiality
MH  - Cost-Benefit Analysis
MH  - Dementia/complications
MH  - *Geriatrics
MH  - Government Regulation
MH  - Health Services Accessibility
MH  - Humans
MH  - Independent Living
MH  - Informed Consent
MH  - Interpersonal Relations
MH  - Licensure
MH  - *Monitoring, Ambulatory
MH  - Personal Autonomy
MH  - Prejudice
MH  - Reimbursement Mechanisms
MH  - State Government
MH  - Telemedicine/*trends
MH  - *Telemetry
EDAT- 2010/07/22 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/07/22 06:00
PHST- 2010/07/22 06:00 [entrez]
PHST- 2010/07/22 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - JGS2959 [pii]
AID - 10.1111/j.1532-5415.2010.02959.x [doi]
PST - ppublish
SO  - J Am Geriatr Soc. 2010 Aug;58(8):1579-86. doi: 10.1111/j.1532-5415.2010.02959.x. 
      Epub 2010 Jul 14.


PMID- 20645927
OWN - NLM
STAT- MEDLINE
DCOM- 20110120
LR  - 20130520
IS  - 1651-2227 (Electronic)
IS  - 0803-5253 (Linking)
VI  - 99
IP  - 12
DP  - 2010 Dec
TI  - New technologies extend the scope of newborn blood-spot screening, but old
      problems remain unresolved.
PG  - 1766-72
LID - 10.1111/j.1651-2227.2010.01950.x [doi]
AB  - UNLABELLED: The potential of newborn blood-spot screening is expanding rapidly
      with the development of new analytical techniques and treatment methods. At the
      same time, some existing programmes, particularly that for congenital
      hypothyroidism, are coming under scrutiny because of suspicion that they are
      being shaped by analytical performance rather than evidence of clinical need.
      Screening policy varies greatly from country to country. CONCLUSION: Ethical and 
      political considerations may sometimes override formal scientific decision
      models.
CI  - (c) 2010 The Author(s)/Journal Compilation (c) 2010 Foundation Acta Paediatrica.
FAU - Pollitt, Rodney J
AU  - Pollitt RJ
AD  - Clinical Chemistry and Newborn Screening, The Children's Hospital, Sheffield, UK.
      rodney.pollitt@sch.nhs.uk
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Norway
TA  - Acta Paediatr
JT  - Acta paediatrica (Oslo, Norway : 1992)
JID - 9205968
SB  - IM
MH  - *Blood Specimen Collection
MH  - Congenital Hypothyroidism/diagnosis
MH  - Cystic Fibrosis/diagnosis
MH  - Health Policy
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Newborn, Diseases/*diagnosis
MH  - Neonatal Screening/*methods/trends
EDAT- 2010/07/22 06:00
MHDA- 2011/01/21 06:00
CRDT- 2010/07/22 06:00
PHST- 2010/07/22 06:00 [entrez]
PHST- 2010/07/22 06:00 [pubmed]
PHST- 2011/01/21 06:00 [medline]
AID - APA1950 [pii]
AID - 10.1111/j.1651-2227.2010.01950.x [doi]
PST - ppublish
SO  - Acta Paediatr. 2010 Dec;99(12):1766-72. doi: 10.1111/j.1651-2227.2010.01950.x.


PMID- 20645892
OWN - NLM
STAT- MEDLINE
DCOM- 20101214
LR  - 20130520
IS  - 1440-1665 (Electronic)
IS  - 1039-8562 (Linking)
VI  - 18
IP  - 4
DP  - 2010 Aug
TI  - Darwin on the emotions of the insane.
PG  - 295-7
LID - 10.3109/10398561003731197 [doi]
AB  - OBJECTIVE: The aim of this paper is to examine information regarding insane
      people and style of word use in The Expression of the Emotions in Man and
      Animals. CONCLUSION: Some of the observations about 19th century patients are not
      consistent with current observations. These discrepancies may have arisen due to 
      different management practices. Some of these observations may have been or be
      mistaken. The style of words would be considered discriminatory by current
      standards. Darwin and his informants were of the highest moral and ethical
      caliber. However, attitudes and the style of word use has changed over the last
      century.
FAU - Pridmore, Saxby
AU  - Pridmore S
AD  - Discipline of Psychiatry, University of Tasmania, City, TAS, Australia.
      S.Pridmore@utas.edu.au
FAU - Keyon, William
AU  - Keyon W
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - England
TA  - Australas Psychiatry
JT  - Australasian psychiatry : bulletin of Royal Australian and New Zealand College of
      Psychiatrists
JID - 9613603
SB  - IM
MH  - Animals
MH  - Behavior, Animal
MH  - *Expressed Emotion
MH  - History, 19th Century
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Insanity Defense/*history
MH  - Male
MH  - Observation/methods
MH  - Psychiatry/*history/methods
EDAT- 2010/07/22 06:00
MHDA- 2010/12/16 06:00
CRDT- 2010/07/22 06:00
PHST- 2010/07/22 06:00 [entrez]
PHST- 2010/07/22 06:00 [pubmed]
PHST- 2010/12/16 06:00 [medline]
AID - 10.3109/10398561003731197 [doi]
PST - ppublish
SO  - Australas Psychiatry. 2010 Aug;18(4):295-7. doi: 10.3109/10398561003731197.


PMID- 20645608
OWN - NLM
STAT- MEDLINE
DCOM- 20100726
LR  - 20100721
IS  - 0023-7205 (Print)
IS  - 0023-7205 (Linking)
VI  - 107
IP  - 21
DP  - 2010 May 26-Jun 1
TI  - [Ethics Review Boards discriminate the most severely ill--Swedish researchers are
      prevented to participate in an international study].
PG  - 1356-7
FAU - Bjorck, Martin
AU  - Bjorck M
AD  - Akademiska sjukhuset, Uppsala. martin.bjorck@surgsci.uu.se
FAU - Berg, Bengt
AU  - Berg B
FAU - Hedin, Ulf
AU  - Hedin U
FAU - Wingren, Urban
AU  - Wingren U
LA  - swe
PT  - Journal Article
TT  - Etikprovningsnamnderna diskriminerar de svarast sjuka--svenska forskare stoppas
      fran deltagande i internationell studie.
PL  - Sweden
TA  - Lakartidningen
JT  - Lakartidningen
JID - 0027707
SB  - IM
MH  - Aortic Aneurysm, Abdominal/surgery
MH  - Aortic Rupture/surgery
MH  - Biomedical Research/*ethics/legislation & jurisprudence
MH  - Clinical Trials as Topic/*ethics/legislation & jurisprudence
MH  - Drug Evaluation/ethics/legislation & jurisprudence
MH  - Ethics Committees
MH  - *Ethics, Research
MH  - European Union
MH  - Humans
MH  - Informed Consent/*ethics/legislation & jurisprudence
MH  - Severity of Illness Index
MH  - Sweden
EDAT- 2010/07/22 06:00
MHDA- 2010/07/27 06:00
CRDT- 2010/07/22 06:00
PHST- 2010/07/22 06:00 [entrez]
PHST- 2010/07/22 06:00 [pubmed]
PHST- 2010/07/27 06:00 [medline]
PST - ppublish
SO  - Lakartidningen. 2010 May 26-Jun 1;107(21):1356-7.


PMID- 20645469
OWN - HMD
STAT- MEDLINE
DCOM- 20100930
LR  - 20211020
IS  - 0020-7985 (Print)
IS  - 0020-7985 (Linking)
VI  - 48
IP  - 4
DP  - 2010
TI  - Untold stories: biases and selection effects in research with victims of
      trafficking for sexual exploitation.
PG  - 1-37
AB  - Recent discussions of trafficking research have included calls for more
      innovative studies and new methodologies in order to move beyond the current
      trafficking narrative, which is often based on unrepresentative samples and
      overly simplified images. While new methods can potentially play a role in
      expanding the knowledge base on trafficking, this article argues that the
      solution is not entirely about applying new methods, but as much about using
      current methods to greater effect and with careful attention to their limitations
      and ethical constraints. Drawing on the authors' experience in researching
      trafficking issues in a number of projects over the past decade, the article
      outlines and exemplifies some of the methodological and ethical issues to be
      considered and accommodated when conducting research with trafficked persons --
      including unrepresentative samples; access to respondents; selection biases by
      "gatekeepers" and self selection by potential respondents. Such considerations
      should inform not only how research is undertaken but also how this information
      is read and understood. Moreover, many of these considerations equally apply when
      considering the application of new methods within this field. The article
      maintains that a better understanding of how these issues come into play and
      inform trafficking research will translate into tools for conducting improved
      research in this field and, by implication, new perspectives on human
      trafficking.
FAU - Brunovskis, Anette
AU  - Brunovskis A
AD  - Fafo, Institute of Applied International Studies, Oslo, Norway.
FAU - Surtees, Rebecca
AU  - Surtees R
LA  - eng
GR  - R01 HD033551/HD/NICHD NIH HHS/United States
PT  - Historical Article
PT  - Journal Article
PL  - Switzerland
TA  - Int Migr
JT  - International migration (Geneva, Switzerland)
JID - 9882227
MH  - Crime/economics/ethnology/history/legislation & jurisprudence/psychology
MH  - *Crime Victims/economics/education/history/legislation & jurisprudence/psychology
MH  - Ethics/history
MH  - History, 20th Century
MH  - History, 21st Century
MH  - *International Agencies/economics/history/legislation & jurisprudence
MH  - *Jurisprudence/history
MH  - Research/education/history
MH  - *Sex Offenses/economics/ethnology/history/legislation & jurisprudence/psychology
MH  - Sexual Behavior/ethnology/history/physiology/psychology
EDAT- 2010/07/22 06:00
MHDA- 2010/10/01 06:00
CRDT- 2010/07/22 06:00
PHST- 2010/07/22 06:00 [entrez]
PHST- 2010/07/22 06:00 [pubmed]
PHST- 2010/10/01 06:00 [medline]
AID - 10.1111/j.1468-2435.2010.00628.x [doi]
PST - ppublish
SO  - Int Migr. 2010;48(4):1-37. doi: 10.1111/j.1468-2435.2010.00628.x.


PMID- 20645457
OWN - NLM
STAT- MEDLINE
DCOM- 20100727
LR  - 20190923
IS  - 1878-3570 (Electronic)
IS  - 0002-8223 (Linking)
VI  - 110
IP  - 7
DP  - 2010 Jul
TI  - Ethics in business practice.
PG  - 1103-4
FAU - Grandgenett, Rita
AU  - Grandgenett R
AD  - RD Associates of Michigan LLC, Battle Creek, MI, USA.
FAU - Derelian, Doris
AU  - Derelian D
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Diet Assoc
JT  - Journal of the American Dietetic Association
JID - 7503061
SB  - IM
MH  - Conflict of Interest
MH  - Dietetics/*ethics/standards
MH  - *Ethics, Professional
MH  - Evidence-Based Medicine/ethics
MH  - Humans
MH  - Plagiarism
MH  - United States
EDAT- 2010/07/22 06:00
MHDA- 2010/07/28 06:00
CRDT- 2010/07/22 06:00
PHST- 2010/07/22 06:00 [entrez]
PHST- 2010/07/22 06:00 [pubmed]
PHST- 2010/07/28 06:00 [medline]
AID - S0002-8223(10)00609-7 [pii]
AID - 10.1016/j.jada.2010.05.018 [doi]
PST - ppublish
SO  - J Am Diet Assoc. 2010 Jul;110(7):1103-4. doi: 10.1016/j.jada.2010.05.018.


PMID- 20645389
OWN - NLM
STAT- MEDLINE
DCOM- 20110608
LR  - 20100826
IS  - 1521-4036 (Electronic)
IS  - 0323-3847 (Linking)
VI  - 52
IP  - 4
DP  - 2010 Aug
TI  - A group sequential type design for three-arm non-inferiority trials with binary
      endpoints.
PG  - 504-18
LID - 10.1002/bimj.200900188 [doi]
AB  - The three-arm design with a test treatment, an active control and a placebo group
      is the gold standard design for non-inferiority trials if it is ethically
      justifiable to expose patients to placebo. In this paper, we first use the closed
      testing principle to establish the hierarchical testing procedure for the
      multiple comparisons involved in the three-arm design. For the effect
      preservation test we derive the explicit formula for the optimal allocation
      ratios. We propose a group sequential type design, which naturally accommodates
      the hierarchical testing procedure. Under this proposed design, Monte Carlo
      simulations are conducted to evaluate the performance of the sequential effect
      preservation test when the variance of the test statistic is estimated based on
      the restricted maximum likelihood estimators of the response rates under the null
      hypothesis. When there are uncertainties for the placebo response rate, the
      proposed design demonstrates better operating characteristics than the fixed
      sample design.
FAU - Li, Gang
AU  - Li G
AD  - GlaxoSmithKline, 1250 S. Collegeville Rd, Collegeville, PA 19426, USA.
      gang.6.li@gsk.com
FAU - Gao, Shan
AU  - Gao S
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Biom J
JT  - Biometrical journal. Biometrische Zeitschrift
JID - 7708048
SB  - IM
MH  - Clinical Trials as Topic/*methods
MH  - Humans
MH  - Monte Carlo Method
MH  - Risk
EDAT- 2010/07/21 06:00
MHDA- 2011/06/09 06:00
CRDT- 2010/07/21 06:00
PHST- 2010/07/21 06:00 [entrez]
PHST- 2010/07/21 06:00 [pubmed]
PHST- 2011/06/09 06:00 [medline]
AID - 10.1002/bimj.200900188 [doi]
PST - ppublish
SO  - Biom J. 2010 Aug;52(4):504-18. doi: 10.1002/bimj.200900188.


PMID- 20645040
OWN - NLM
STAT- MEDLINE
DCOM- 20110104
LR  - 20100913
IS  - 1496-8975 (Electronic)
IS  - 0832-610X (Linking)
VI  - 57
IP  - 10
DP  - 2010 Oct
TI  - Hospital administrative database underestimates delirium rate after cardiac
      surgery.
PG  - 898-902
LID - 10.1007/s12630-010-9355-8 [doi]
AB  - PURPOSE: Administrative electronic databases are highly specific for
      postoperative complications, but they lack sensitivity. The objective of this
      study was to determine the incidence of delirium after cardiac surgery using a
      targeted prospectively collected dataset and to compare the findings with the
      incidence of delirium in the same cohort of patients identified in a hospital
      administrative database. METHODS: Following Research Ethics Board approval, we
      compared delirium rates in a prospectively collected data research database with 
      delirium rates in the same cohort of patients in an administrative hospital
      database where delirium was identified from codes entered by coding and
      abstracting staff. Every 12 hr postoperatively, delirium was assessed with a
      Confusion Assessment Method in the Intensive Care Unit. The administrative
      database contained the International Classification of Diseases version 10
      (ICD-10) codes for patient diagnoses. The ICD-10 codes were extracted from the
      administrative database for each patient in the research database and were
      checked for the presence of the ICD-10 code for delirium. RESULTS: Data from a
      cohort of 1,528 patients were analyzed. Postoperative delirium was identified in 
      182 (11.9%) patients (95% confidence interval [CI], 10.3-13.5%) in the research
      dataset and 46 (3%) patients (95% CI, 2.2-3.8%) in the administrative dataset (P 
      < 0.001). Thirteen (0.85%) patients who were coded for delirium in the
      administrative database were not identified in the research dataset. The median
      onset of postoperative delirium in these patients was significantly delayed (4
      [3-9] days) compared with patients identified by both datasets (2 [1-9] days) and
      compared with patients from the research database only (1 [1-14] days) (P =
      0.007). CONCLUSION: Postoperative delirium rates after cardiac surgery are
      underestimated by the hospital administrative database.
FAU - Katznelson, Rita
AU  - Katznelson R
AD  - Department of Anesthesiology, Toronto General Hospital, Eaton North 3-453, 200
      Elizabeth Street, Toronto, ON M5G 2C4, Canada. rita.katznelson@uhn.on.ca
FAU - Djaiani, George
AU  - Djaiani G
FAU - Tait, Gordon
AU  - Tait G
FAU - Wasowicz, Marcin
AU  - Wasowicz M
FAU - Sutherland, Ainsley M
AU  - Sutherland AM
FAU - Styra, Rima
AU  - Styra R
FAU - Lee, Corina
AU  - Lee C
FAU - Beattie, W Scott
AU  - Beattie WS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100720
PL  - United States
TA  - Can J Anaesth
JT  - Canadian journal of anaesthesia = Journal canadien d'anesthesie
JID - 8701709
SB  - IM
MH  - Aged
MH  - Cardiac Surgical Procedures/*adverse effects
MH  - Databases, Factual/*standards/statistics & numerical data
MH  - Delirium/diagnosis/*epidemiology/etiology
MH  - Female
MH  - Hospitals/statistics & numerical data
MH  - Humans
MH  - International Classification of Diseases
MH  - Male
MH  - Middle Aged
MH  - Postoperative Complications/diagnosis/*epidemiology/etiology
MH  - Prospective Studies
MH  - Retrospective Studies
MH  - Time Factors
EDAT- 2010/07/21 06:00
MHDA- 2011/01/05 06:00
CRDT- 2010/07/21 06:00
PHST- 2010/02/24 00:00 [received]
PHST- 2010/07/01 00:00 [accepted]
PHST- 2010/07/21 06:00 [entrez]
PHST- 2010/07/21 06:00 [pubmed]
PHST- 2011/01/05 06:00 [medline]
AID - 10.1007/s12630-010-9355-8 [doi]
PST - ppublish
SO  - Can J Anaesth. 2010 Oct;57(10):898-902. doi: 10.1007/s12630-010-9355-8. Epub 2010
      Jul 20.


PMID- 20644508
OWN - NLM
STAT- MEDLINE
DCOM- 20100809
LR  - 20211020
IS  - 1940-087X (Electronic)
IS  - 1940-087X (Linking)
IP  - 41
DP  - 2010 Jul 3
TI  - Isolation of human umbilical arterial smooth muscle cells (HUASMC).
LID - 10.3791/1940 [doi]
LID - 1940 [pii]
AB  - The human umbilical cord (UC) is a biological sample that can be easily obtained 
      just after birth. This biological sample is, most of the time, discarded and
      their collection does not imply any added risk to the newborn or mother s health.
      Moreover no ethical concerns are raised. The UC is composed by one vein and two
      arteries from which both endothelial cells (ECs) and smooth muscle cells (SMCs), 
      two of the main cellular components of blood vessels, can be isolated. In this
      project the SMCs were obtained after enzymatic treatment of the UC arteries
      accordingly the experimental procedure previously described by Jaffe et al. After
      cell isolation they were kept in t-flash with DMEM-F12 supplemented with 5% of
      fetal bovine serum and were cultured for several passages. Cells maintained their
      morphological and other phenotypic characteristics in the different generations. 
      The aim of this study was to isolate smooth muscle cells in order to use them as 
      models for future assays with constrictor drugs, isolate and structurally
      characterize L-type calcium channels, to study cellular and molecular aspects of 
      the vascular function and to use them in tissue engineering.
FAU - Ribeiro, Maximiano P
AU  - Ribeiro MP
AD  - Centro de Investigacao em Ciencias da Saude, Faculdade de Ciencias da Saude,
      Universidade da Beira Interior.
FAU - Relvas, Ricardo
AU  - Relvas R
FAU - Chiquita, Samuel
AU  - Chiquita S
FAU - Correia, Ilidio J
AU  - Correia IJ
LA  - eng
PT  - Journal Article
PT  - Video-Audio Media
DEP - 20100703
PL  - United States
TA  - J Vis Exp
JT  - Journal of visualized experiments : JoVE
JID - 101313252
SB  - IM
MH  - Animals
MH  - Cattle
MH  - Cell Culture Techniques/methods
MH  - Cell Separation/*methods
MH  - Centrifugation/methods
MH  - Humans
MH  - Muscle, Smooth, Vascular/*cytology
MH  - Umbilical Arteries/*cytology
PMC - PMC3156078
EDAT- 2010/07/21 06:00
MHDA- 2010/08/10 06:00
CRDT- 2010/07/21 06:00
PHST- 2010/07/21 06:00 [entrez]
PHST- 2010/07/21 06:00 [pubmed]
PHST- 2010/08/10 06:00 [medline]
AID - 1940 [pii]
AID - 10.3791/1940 [doi]
PST - epublish
SO  - J Vis Exp. 2010 Jul 3;(41). pii: 1940. doi: 10.3791/1940.


PMID- 20644192
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20211020
IS  - 1544-1717 (Electronic)
IS  - 1544-1709 (Linking)
VI  - 8
IP  - 4
DP  - 2010 Jul-Aug
TI  - Identifying and addressing potential conflict of interest: a professional medical
      organization's code of ethics.
PG  - 359-61
LID - 10.1370/afm.1146 [doi]
AB  - The new Consumer Alliance agreement between the American Academy of Family
      Physicians (AAFP) and The Coca-Cola Company provides a valuable opportunity to
      illustrate AAFP's adherence to its ethical foundation, demonstrate the AAFP's
      commitment to serving physicians and the public, and maintain the trust Americans
      put in their family physicians and the organization that represents them.
      Throughout the development of this program, as well as in all business
      interactions, the AAFP consistently addresses possible conflict of interest
      openly and directly, sharing with our members and the public exactly what
      measures we take to ensure that, in fact, no unethical conduct or breach of trust
      would--or will in the future--occur. In this case, the AAFP saw a public health
      and education need that was both unmet and undermined by the barrage of marketing
      messages and confusing information, and acted to fill that need. In so doing, the
      AAFP hewed to its high ethical standards, its core values, and its mission in the
      decisions made and the actions that followed.
FAU - Heim, Lori
AU  - Heim L
AD  - American Academy of Family Physicians, Leawood, Kansas 66211-2672, USA.
      lheim@aafp.org
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Fam Med
JT  - Annals of family medicine
JID - 101167762
SB  - IM
MH  - *Conflict of Interest
MH  - Efficiency, Organizational
MH  - *Ethics, Medical
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Public Health/*ethics
MH  - Societies, Medical/*ethics
PMC - PMC2906532
EDAT- 2010/07/21 06:00
MHDA- 2011/01/07 06:00
CRDT- 2010/07/21 06:00
PHST- 2010/07/21 06:00 [entrez]
PHST- 2010/07/21 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
AID - 8/4/359 [pii]
AID - 10.1370/afm.1146 [doi]
PST - ppublish
SO  - Ann Fam Med. 2010 Jul-Aug;8(4):359-61. doi: 10.1370/afm.1146.


PMID- 20644191
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20211020
IS  - 1544-1717 (Electronic)
IS  - 1544-1709 (Linking)
VI  - 8
IP  - 4
DP  - 2010 Jul-Aug
TI  - Professional medical organizations and commercial conflicts of interest: ethical 
      issues.
PG  - 354-8
LID - 10.1370/afm.1140 [doi]
AB  - The American Academy of Family Physicians (AAFP) has recently been criticized for
      accepting a large corporate donation from Coca-Cola to fund patient education on 
      obesity prevention. Conflicts of interest, whether individual or organizational, 
      occur when one enters into arrangements that reasonably tempt one to put aside
      one's primary obligations in favor of secondary interests, such as financial
      self-interest. Accepting funds from commercial sources that seek to influence
      physician organizational behavior in a direction that could run counter to the
      public health represents one of those circumstances and so constitutes a conflict
      of interest. Most of the defenses offered by AAFP are rationalizations rather
      than ethical counterarguments. Medical organizations, as the public face of
      medicine and as formulator of codes of ethics for their physician members, have
      special obligations to adhere to high ethical standards.
FAU - Brody, Howard
AU  - Brody H
AD  - Institute for the Medical Humanities and Department of Family Medicine,
      University of Texas Medical Branch, Galveston, Texas 77555-1311, USA.
      habrody@utmb.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Fam Med
JT  - Annals of family medicine
JID - 101167762
SB  - IM
CIN - Indian J Med Ethics. 2011 Jan-Mar;8(1):52-4. PMID: 22106604
MH  - *Conflict of Interest
MH  - Drug Industry/*ethics
MH  - *Ethics, Medical
MH  - Humans
MH  - Physicians/*ethics
MH  - Public Health/*ethics
MH  - Societies, Medical/*ethics
MH  - Trust
MH  - United States
PMC - PMC2906531
EDAT- 2010/07/21 06:00
MHDA- 2011/01/07 06:00
CRDT- 2010/07/21 06:00
PHST- 2010/07/21 06:00 [entrez]
PHST- 2010/07/21 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
AID - 8/4/354 [pii]
AID - 10.1370/afm.1140 [doi]
PST - ppublish
SO  - Ann Fam Med. 2010 Jul-Aug;8(4):354-8. doi: 10.1370/afm.1140.


PMID- 20644181
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20211020
IS  - 1544-1717 (Electronic)
IS  - 1544-1709 (Linking)
VI  - 8
IP  - 4
DP  - 2010 Jul-Aug
TI  - Ethics, support for care, prevention, and what's important.
PG  - 290-1
LID - 10.1370/afm.1149 [doi]
FAU - Stange, Kurt C
AU  - Stange KC
LA  - eng
PT  - Editorial
PT  - Introductory Journal Article
PL  - United States
TA  - Ann Fam Med
JT  - Annals of family medicine
JID - 101167762
SB  - IM
MH  - *Ethics, Medical
MH  - Humans
MH  - Patient Care/*ethics
MH  - *Preventive Medicine
PMC - PMC2906521
EDAT- 2010/07/21 06:00
MHDA- 2011/01/07 06:00
CRDT- 2010/07/21 06:00
PHST- 2010/07/21 06:00 [entrez]
PHST- 2010/07/21 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
AID - 8/4/290 [pii]
AID - 10.1370/afm.1149 [doi]
PST - ppublish
SO  - Ann Fam Med. 2010 Jul-Aug;8(4):290-1. doi: 10.1370/afm.1149.


PMID- 20643694
OWN - NLM
STAT- MEDLINE
DCOM- 20101222
LR  - 20100818
IS  - 1460-2350 (Electronic)
IS  - 0268-1161 (Linking)
VI  - 25
IP  - 9
DP  - 2010 Sep
TI  - Complicity in stem cell research: the case of induced pluripotent stem cells.
PG  - 2175-80
LID - 10.1093/humrep/deq176 [doi]
AB  - Many who object to human embryonic stem cell (hESC) research because they believe
      it involves complicity in embryo destruction have welcomed induced pluripotent
      stem cell (iPSC) research as an ethical alternative. This opinion article aims to
      show that complicity arguments against hESC research are prima facie inconsistent
      with accepting iPSC research as it is currently done. Those who oppose hESC
      research on grounds of complicity should either (i) oppose iPSC research as well,
      (ii) advocate a radical change in the way iPSC research is done, (iii)
      demonstrate that complicity arguments against iPSC research are weaker than those
      against hESC research or (iv) reject complicity arguments against both hESC and
      iPSC research, either by adopting a more limited conception of complicity that
      allows acceptance of some hESC research, or by accepting that destroying embryos 
      for important scientific research is not wrong.
FAU - Devolder, Katrien
AU  - Devolder K
AD  - Bioethics Institute Ghent, Department of Philosophy and Moral Sciences, Ghent
      University, Blandijnberg 2, 9000 Ghent, Belgium. katrien.devolder@ugent.be
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100719
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
SB  - IM
MH  - Cell Line
MH  - *Complicity
MH  - *Embryonic Stem Cells
MH  - Humans
MH  - *Induced Pluripotent Stem Cells
MH  - Research Embryo Creation/ethics
MH  - Stem Cell Research/*ethics
EDAT- 2010/07/21 06:00
MHDA- 2010/12/24 06:00
CRDT- 2010/07/21 06:00
PHST- 2010/07/21 06:00 [entrez]
PHST- 2010/07/21 06:00 [pubmed]
PHST- 2010/12/24 06:00 [medline]
AID - deq176 [pii]
AID - 10.1093/humrep/deq176 [doi]
PST - ppublish
SO  - Hum Reprod. 2010 Sep;25(9):2175-80. doi: 10.1093/humrep/deq176. Epub 2010 Jul 19.


PMID- 20642939
OWN - NLM
STAT- MEDLINE
DCOM- 20100930
LR  - 20140730
IS  - 1022-386X (Print)
IS  - 1022-386X (Linking)
VI  - 20
IP  - 7
DP  - 2010 Jul
TI  - Induced remote ischemic pre-conditioning on ischemia-reperfusion injury in
      patients undergoing coronary artery bypass.
PG  - 427-31
LID - 07.2010/JCPSP.427431 [doi]
AB  - OBJECTIVE: To determine the role of remote ischemic pre-conditioning (rIPC) on
      myocardium, against ischemia reperfusion injury in patients undergoing coronary
      artery bypass graft (CABG) surgery by measuring CKMB levels. STUDY DESIGN: A
      randomized controlled trial. PLACE AND DURATION OF STUDY: The Surgical Department
      of Armed Forces Institute of Cardiology/National Institute of Heart Diseases,
      Rawalpindi, from January to June 2008. METHODOLOGY: One hundred patients with
      double and triple vessels coronary artery disease were randomized in two groups
      of 50 each. rIPC protocol consisted of 3 x 5 minutes of forearm ischemia, induced
      by a blood pressure cuff inflated to 200 mmHg, with an intervening 5 minutes of
      reperfusion, during which the cuff was deflated. Patients in the control group
      were not subjected to limb ischemia. The protocol of induced ischemia was
      completed before placing patients on extracorporeal bypass circuit. At the end of
      surgery serum CKMB levels were measured and compared at 8, 16, 24 and 48 hours
      from both the groups. Written informed consent was taken from patients. Study was
      approved by the hospital ethical committee. RESULTS: Remote ischemic
      pre-conditioning significantly reduced CKMB levels at 8, 16, 24 and 48 hours
      after surgery with p-values of 0.026, 0.021, 0.052 and 0.003 respectively. There 
      was mean reduction of 3 iu/l in CKMB levels, in patients who underwent rIPC
      protocol prior to CABG surgery, compared to control group. CONCLUSION: This study
      showed a significant reduction of enzyme marker CKMB in patients subjected to
      rIPC prior to CABG surgery. This suggests lesser degree of myocardial damage
      compared to control group in CABG patients.
FAU - Ali, Nasir
AU  - Ali N
AD  - Department of Cardiac Surgery, Armed Forces Institute of Cardiology, National
      Institute of Heart Diseases, Rawalpindi, Pakistan.
FAU - Rizwi, Farwa
AU  - Rizwi F
FAU - Iqbal, Afsheen
AU  - Iqbal A
FAU - Rashid, Azhar
AU  - Rashid A
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Pakistan
TA  - J Coll Physicians Surg Pak
JT  - Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
JID - 9606447
RN  - EC 2.7.3.2 (Creatine Kinase, MB Form)
SB  - IM
MH  - Adult
MH  - *Coronary Artery Bypass
MH  - Creatine Kinase, MB Form/blood
MH  - Female
MH  - Humans
MH  - Ischemic Preconditioning, Myocardial/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardial Reperfusion Injury/blood/*prevention & control
EDAT- 2010/07/21 06:00
MHDA- 2010/10/01 06:00
CRDT- 2010/07/21 06:00
PHST- 2008/10/08 00:00 [received]
PHST- 2010/04/28 00:00 [accepted]
PHST- 2010/07/21 06:00 [entrez]
PHST- 2010/07/21 06:00 [pubmed]
PHST- 2010/10/01 06:00 [medline]
AID - 040579197 [pii]
AID - 07.2010/JCPSP.427431 [doi]
PST - ppublish
SO  - J Coll Physicians Surg Pak. 2010 Jul;20(7):427-31. doi: 07.2010/JCPSP.427431.


PMID- 20642914
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20180126
IS  - 2444-054X (Electronic)
IS  - 0009-7411 (Linking)
VI  - 78
IP  - 3
DP  - 2010 May-Jun
TI  - Diagnostic-therapeutic approach to breast cancer associated with pregnancy:
      update 2010.
PG  - 271-9
AB  - Breast cancer associated with pregnancy (defined as the presence of breast cancer
      during gestation extending until a year after the resolution of the pregnancy)
      represents controversial ethical dilemmas and contradictions in its diagnostic
      and therapeutic approach. Diagnostic methods and the role of pregnancy
      interruption are controversial subjects for prognosis. Our objective was to
      discuss the recommendations for diagnosis and treatment for these patients using 
      evidence-based medicine and to discuss controversial subjects such as the role of
      lymphatic mapping, pre-therapeutic studies and appropriate treatment schedule.
      Fortunately, the prevalence of breast cancer during pregnancy is low. It is
      generally considered, however, that this prevalence will slowly increase because 
      of two factors: 1) breast cancer is showing an increasing prevalence and 2) in
      Western societies the age when a woman becomes pregnant for the first time has
      increased, which is also associated with the age when breast cancer frequency
      rises. As in the general population, breast cancer is the most frequent neoplasm 
      in pregnant women. When diagnostic questions arise that sometimes do not have an 
      answer based on scientific evidence, therapeutic decisions are often made based
      on knowledge acquired in breast cancer treatment of nonpregnant women. To
      routinely apply new diagnostic/therapeutic technologies with the safety of
      protecting the pregnancy is a difficult decision to make. In the end, the main
      objective of treatment of a pregnant woman with breast cancer is to maintain the 
      standard of the desired oncological results while preserving the integrity of the
      fetus.
FAU - Gallegos-Hernandez, Jose Francisco
AU  - Gallegos-Hernandez JF
AD  - Hospital Angeles Lomas, Huixquilucan, Estado de Mexico. gal61@prodigy.net.mx
LA  - eng
LA  - spa
PT  - Journal Article
PL  - Mexico
TA  - Cir Cir
JT  - Cirugia y cirujanos
JID - 0372736
SB  - IM
MH  - Breast Neoplasms/*diagnosis/*therapy
MH  - Female
MH  - Humans
MH  - Pregnancy
MH  - Pregnancy Complications, Neoplastic/*diagnosis/*therapy
EDAT- 2010/07/21 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/07/21 06:00
PHST- 2010/07/21 06:00 [entrez]
PHST- 2010/07/21 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
PST - ppublish
SO  - Cir Cir. 2010 May-Jun;78(3):271-9.


PMID- 20642868
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1756-994X (Electronic)
IS  - 1756-994X (Linking)
VI  - 2
IP  - 7
DP  - 2010 Jul 17
TI  - Ethical issues raised by common copy number variants and single nucleotide
      polymorphisms of certain and uncertain significance in general medical practice.
PG  - 42
LID - 10.1186/gm163 [doi]
AB  - The ethical issues surrounding genotyping for single nucleotide polymorphisms
      (SNPs) or for copy number variation (CNV) are very different. SNP genotyping can 
      focus on ancestry, risk probability, single gene diagnosis, pharmacogenetics, and
      carrier testing, and the combination of these in a single test can present
      difficulties. The interpretation of such tests, inconsistencies between
      laboratories, and access to genotype information for future reference need to be 
      considered, as well as the value of genotypes of known clinical significance
      compared with those that provide modest risk modifications with limited potential
      to take medically useful steps. For CNV genotyping, the major concerns relate to 
      CNVs of uncertain significance and to those with incomplete penetrance. Such CNVs
      present acute difficulties in counseling symptomatic and asymptomatic individuals
      and have substantial potential for stigmatization of both groups, as well as
      raising difficulties when detected in prenatal diagnosis. Improved prenatal
      diagnosis of many disorders provided by array tests compared with the traditional
      karyotype probably outweighs the uncertainties for families who would terminate
      pregnancies with findings associated with severe disabilities. There are
      substantive concerns about offering SNP or CNV genotyping direct to consumers
      without a physician or counselor to provide guidance for interpretation of the
      results.
FAU - Beaudet, Arthur L
AU  - Beaudet AL
AD  - Department of Molecular and Human Genetics, Baylor College of Medicine, One
      Baylor Plaza, BCM225, Houston, TX 77030, USA. abeaudet@bcm.edu.
LA  - eng
PT  - Editorial
DEP - 20100717
PL  - England
TA  - Genome Med
JT  - Genome medicine
JID - 101475844
PMC - PMC2923734
EDAT- 2010/07/21 06:00
MHDA- 2010/07/21 06:01
CRDT- 2010/07/21 06:00
PHST- 2010/07/21 06:00 [entrez]
PHST- 2010/07/21 06:00 [pubmed]
PHST- 2010/07/21 06:01 [medline]
AID - gm163 [pii]
AID - 10.1186/gm163 [doi]
PST - epublish
SO  - Genome Med. 2010 Jul 17;2(7):42. doi: 10.1186/gm163.


PMID- 20642677
OWN - NLM
STAT- MEDLINE
DCOM- 20101029
LR  - 20211020
IS  - 1600-6143 (Electronic)
IS  - 1600-6135 (Linking)
VI  - 10
IP  - 7
DP  - 2010 Jul
TI  - Retroviral restriction factors and infectious risk in xenotransplantation.
PG  - 1511-6
LID - 10.1111/j.1600-6143.2010.03146.x [doi]
AB  - The clinical application of xenotransplantation poses immunologic, ethical, and
      microbiologic challenges. Significant progress has been made in the investigation
      of each of these areas. Among concerns regarding infectious risks for human
      xenograft recipients is the identification in swine of infectious agents
      including porcine endogenous retroviruses (PERV) that are capable of replication 
      in some human cell lines. PERV replication has, however, been difficult to
      demonstrate in primate-derived cell lines and in preclinical studies of non-human
      primates receiving porcine xenografts. Endogenous 'retroviral restriction
      factors' are intracellular proteins and components of the innate immune system
      that act at various steps in retroviral replication. Recent studies suggest that 
      some of these factors may have applications in the management of endogenous
      retroviruses in xenotransplantation. The risks of PERV infection and the
      potential role of retroviral restriction factors in xenotransplantation are
      reviewed in detail.
FAU - Meije, Y
AU  - Meije Y
AD  - Hospital Universitario 12 de Octubre, Madrid, Spain.
FAU - Tonjes, R R
AU  - Tonjes RR
FAU - Fishman, J A
AU  - Fishman JA
LA  - eng
GR  - P01 AI045897/AI/NIAID NIH HHS/United States
GR  - P01 AI045897-100008/AI/NIAID NIH HHS/United States
GR  - P01-AI45897/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
RN  - 0 (Antigens, CD)
RN  - 0 (BST2 protein, human)
RN  - 0 (GPI-Linked Proteins)
RN  - 0 (Membrane Glycoproteins)
SB  - IM
MH  - Animals
MH  - Antigens, CD/physiology
MH  - Endogenous Retroviruses/pathogenicity
MH  - GPI-Linked Proteins
MH  - Genome, Viral
MH  - Humans
MH  - Infections/*epidemiology
MH  - Life Cycle Stages
MH  - Membrane Glycoproteins/physiology
MH  - Retroviridae/genetics/*isolation & purification/physiology
MH  - Retroviridae Infections/*epidemiology/prevention & control
MH  - Risk Factors
MH  - Swine
MH  - Transplantation, Heterologous/*adverse effects/methods
PMC - PMC2909010
MID - NIHMS203842
EDAT- 2010/07/21 06:00
MHDA- 2010/10/30 06:00
CRDT- 2010/07/21 06:00
PHST- 2010/07/21 06:00 [entrez]
PHST- 2010/07/21 06:00 [pubmed]
PHST- 2010/10/30 06:00 [medline]
AID - AJT3146 [pii]
AID - 10.1111/j.1600-6143.2010.03146.x [doi]
PST - ppublish
SO  - Am J Transplant. 2010 Jul;10(7):1511-6. doi: 10.1111/j.1600-6143.2010.03146.x.


PMID- 20642628
OWN - NLM
STAT- MEDLINE
DCOM- 20101103
LR  - 20110107
IS  - 1745-6584 (Electronic)
IS  - 0017-467X (Linking)
VI  - 48
IP  - 4
DP  - 2010 Jul-Aug
TI  - Comment on guest editorial: "Role of ethics in groundwater management".
PG  - 480-1; discussion 481
LID - 10.1111/j.1745-6584.2010.00700.x [doi]
FAU - Heuvelmans, Griet
AU  - Heuvelmans G
AD  - Flemish Environment Agency, Koning Albert II Laan 20 Bus 16, 1000 Brussel,
      Belgium. g.heuvelmans@vmm.be
FAU - Louwyck, Andy
AU  - Louwyck A
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Ground Water
JT  - Ground water
JID - 9882886
SB  - IM
CON - Ground Water. 2010 Jan-Feb;48(1):1. PMID: 19664044
MH  - Conservation of Natural Resources
MH  - Environmental Monitoring/*ethics
MH  - *Fresh Water
EDAT- 2010/07/21 06:00
MHDA- 2010/11/04 06:00
CRDT- 2010/07/21 06:00
PHST- 2010/07/21 06:00 [entrez]
PHST- 2010/07/21 06:00 [pubmed]
PHST- 2010/11/04 06:00 [medline]
AID - GWAT700 [pii]
AID - 10.1111/j.1745-6584.2010.00700.x [doi]
PST - ppublish
SO  - Ground Water. 2010 Jul-Aug;48(4):480-1; discussion 481. doi:
      10.1111/j.1745-6584.2010.00700.x.


PMID- 20642307
OWN - NLM
STAT- MEDLINE
DCOM- 20101025
LR  - 20220309
IS  - 1935-990X (Electronic)
IS  - 0003-066X (Linking)
VI  - 65
IP  - 5
DP  - 2010 Jul-Aug
TI  - 2010 Amendments to the 2002 "Ethical principles of psychologists and code of
      conduct".
PG  - 493
LID - 10.1037/a0020168 [doi]
AB  - The following amendments to the 2002 "Ethical Principles of Psychologists and
      Code of Conduct" (the Ethics Code; American Psychological Association, 2002) were
      adopted by the APA Council of Representatives at its February 2010 meeting. The
      changes involve the last two sentences of the final paragraph of the Introduction
      and Applicability section and Ethical Standards 1.02 and 1.03. The amendments
      became effective June 1, 2010. A history of these amendments to the Ethics Code
      is provided in the "Report of the Ethics Committee, 2009" in this issue of the
      American Psychologist (American Psychological Association, Ethics Committee,
      2010). Following are a clean version of the revisions and a version indicating
      changes from the 2002 language (inserted text is underlined; deleted text is
      crossed out).
CI  - 2010 APA, all rights reserved.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am Psychol
JT  - The American psychologist
JID - 0370521
SB  - IM
MH  - *Codes of Ethics
MH  - Ethics, Professional
MH  - Humans
MH  - Psychology/*ethics
MH  - Societies, Scientific/*ethics
EDAT- 2010/07/21 06:00
MHDA- 2010/10/26 06:00
CRDT- 2010/07/21 06:00
PHST- 2010/07/21 06:00 [entrez]
PHST- 2010/07/21 06:00 [pubmed]
PHST- 2010/10/26 06:00 [medline]
AID - 2010-14198-011 [pii]
AID - 10.1037/a0020168 [doi]
PST - ppublish
SO  - Am Psychol. 2010 Jul-Aug;65(5):493. doi: 10.1037/a0020168.


PMID- 20642306
OWN - NLM
STAT- MEDLINE
DCOM- 20101025
LR  - 20100720
IS  - 1935-990X (Electronic)
IS  - 0003-066X (Linking)
VI  - 65
IP  - 5
DP  - 2010 Jul-Aug
TI  - Report of the ethics committee, 2009.
PG  - 483-92
LID - 10.1037/a0019515 [doi]
AB  - In accordance with the bylaws of the American Psychological Association (APA),
      the Ethics Committee reports regularly to the membership regarding the number and
      types of ethics complaints investigated and the major programs undertaken. This
      article is a summary of the talks and workshops of 2009, ethics adjudication,
      ethics education and consultation, and special projects among the activities of
      the Ethics Committee.
CI  - 2010 APA, all rights reserved.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am Psychol
JT  - The American psychologist
JID - 0370521
SB  - IM
MH  - *Committee Membership
MH  - *Ethics
MH  - *Ethics Committees
MH  - *Societies, Scientific
MH  - United States
EDAT- 2010/07/21 06:00
MHDA- 2010/10/26 06:00
CRDT- 2010/07/21 06:00
PHST- 2010/07/21 06:00 [entrez]
PHST- 2010/07/21 06:00 [pubmed]
PHST- 2010/10/26 06:00 [medline]
AID - 2010-14198-010 [pii]
AID - 10.1037/a0019515 [doi]
PST - ppublish
SO  - Am Psychol. 2010 Jul-Aug;65(5):483-92. doi: 10.1037/a0019515.


PMID- 20642237
OWN - NLM
STAT- MEDLINE
DCOM- 20100812
LR  - 20180221
IS  - 1750-4589 (Print)
IS  - 1750-4589 (Linking)
VI  - 20
IP  - 3
DP  - 2010 Mar
TI  - The surgical care practitioner: a critical analysis.
PG  - 94-9
AB  - The role of the surgical care practitioner has been in existence for many years
      in some form or another with a variety of job titles and a wide range of duties. 
      With the adoption of the European Working Time Directive and the need for skilled
      assistance, not only at the operating table but also pre and post surgery, the
      role is becoming formalised with voluntary codes of conduct, performance, ethics,
      standards and scope of practice.
FAU - Nicholas, Michael
AU  - Nicholas M
AD  - William Harvey Hospital, Ashford TN24 0LZ. Micahel.Nicholas@ekht.nhs.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Perioper Pract
JT  - Journal of perioperative practice
JID - 101271023
MH  - *General Surgery/education/ethics
MH  - Humans
MH  - *Nurse Practitioners/education/ethics
MH  - Nurse's Role
MH  - Patient Satisfaction
MH  - Trust
MH  - United Kingdom
EDAT- 2010/07/21 06:00
MHDA- 2010/08/13 06:00
CRDT- 2010/07/21 06:00
PHST- 2010/07/21 06:00 [entrez]
PHST- 2010/07/21 06:00 [pubmed]
PHST- 2010/08/13 06:00 [medline]
AID - 10.1177/175045891002000301 [doi]
PST - ppublish
SO  - J Perioper Pract. 2010 Mar;20(3):94-9. doi: 10.1177/175045891002000301.


PMID- 20642178
OWN - NLM
STAT- MEDLINE
DCOM- 20100818
LR  - 20191111
IS  - 1526-9248 (Print)
IS  - 1526-9248 (Linking)
VI  - 20
IP  - 2
DP  - 2010 Jun
TI  - Ethical considerations in live liver donation to children.
PG  - 186-90
AB  - Transplant professionals are often faced with ethical situations in practice. In 
      the field of pediatric transplantation, these ethical dilemmas can be even more
      profound than in adults. Transplant professionals must have a firm foundation of 
      professional and personal ethical principles in order to handle ethical
      situations they encounter. This paper provides an ethical review of issues that
      arise during live liver donation from a parent to a child.
FAU - Ventura, Kara Ann
AU  - Ventura KA
AD  - Center for Liver Disease and Transplantation, Morgan Stanley Children's Hospital 
      of New York Presbyterian, New York, NY 10032, USA. kv49@columbia.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Prog Transplant
JT  - Progress in transplantation (Aliso Viejo, Calif.)
JID - 100909380
MH  - Child
MH  - Decision Making/*ethics
MH  - Female
MH  - Humans
MH  - Informed Consent/ethics
MH  - Liver Transplantation/*ethics
MH  - Living Donors/*ethics
MH  - Male
MH  - *Parents
MH  - Patient Advocacy/ethics
MH  - United States
EDAT- 2010/07/21 06:00
MHDA- 2010/08/19 06:00
CRDT- 2010/07/21 06:00
PHST- 2010/07/21 06:00 [entrez]
PHST- 2010/07/21 06:00 [pubmed]
PHST- 2010/08/19 06:00 [medline]
AID - 10.7182/prtr.20.2.p647835g52126054 [doi]
PST - ppublish
SO  - Prog Transplant. 2010 Jun;20(2):186-90. doi: 10.7182/prtr.20.2.p647835g52126054.


PMID- 20642177
OWN - NLM
STAT- MEDLINE
DCOM- 20100818
LR  - 20191111
IS  - 1526-9248 (Print)
IS  - 1526-9248 (Linking)
VI  - 20
IP  - 2
DP  - 2010 Jun
TI  - Too poor for transplant: finance and insurance issues in transplant ethics.
PG  - 178-85
AB  - CONTEXT: Donor organs are a scarce gift. Additionally, transplantation is very
      expensive and the United States lacks universal health insurance for all
      citizens. These facts combine to make personal finance and insurance some of the 
      criteria for wait listing at US transplant centers. Previous research has shown
      that the poor and the uninsured (as well as women and nonwhites) are less likely 
      to receive a transplant. Living donor candidates are also limited by the US
      insurance system. OBJECTIVE: To determine the effect of finance and insurance
      variables on access to transplant and living donation. DESIGN: A qualitative
      descriptive study of ethics consultation data contained in a research registry
      approved by the institutional review board at California Pacific Medical Center. 
      SETTING AND PARTICIPANTS: This study analyzes research registry data from a large
      community hospital in Northern California that serves patients from California,
      Oregon, and Nevada. The registry data are derived from transplant ethics
      consultations occurring between January 1, 2007, and June 30, 2009. MAIN OUTCOME 
      MEASURE: This study explores the restriction of access to transplantation and of 
      participation in living donation. RESULTS: More than a quarter of all transplant 
      ethics consultation reports described the restriction of transplant-related
      treatment for reasons rooted in finance or insurance. Individuals on the
      recipient side and on the donor side were hindered with regard to access.
      Insurance status and personal ability to pay significantly affect access to
      transplantation in the United States, and this theme is a frequent feature of
      ethics consultations at California Pacific Medical Center.
FAU - Laurentine, Kyle Alexander
AU  - Laurentine KA
AD  - Department of Transplantation, California Pacific Medical Center, San Francisco, 
      CA 94115, USA. kylelaurentine@gmail.com
FAU - Bramstedt, Katrina A
AU  - Bramstedt KA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Prog Transplant
JT  - Progress in transplantation (Aliso Viejo, Calif.)
JID - 100909380
MH  - California
MH  - Health Services Accessibility/*economics
MH  - Humans
MH  - *Insurance Coverage
MH  - Living Donors/supply & distribution
MH  - Organ Transplantation/*economics/*ethics
MH  - *Poverty
EDAT- 2010/07/21 06:00
MHDA- 2010/08/19 06:00
CRDT- 2010/07/21 06:00
PHST- 2010/07/21 06:00 [entrez]
PHST- 2010/07/21 06:00 [pubmed]
PHST- 2010/08/19 06:00 [medline]
AID - 10.7182/prtr.20.2.xhu0678655331488 [doi]
PST - ppublish
SO  - Prog Transplant. 2010 Jun;20(2):178-85. doi: 10.7182/prtr.20.2.xhu0678655331488.


PMID- 20642074
OWN - NLM
STAT- MEDLINE
DCOM- 20100819
LR  - 20211203
IS  - 1115-2613 (Print)
IS  - 1115-2613 (Linking)
VI  - 19
IP  - 2
DP  - 2010 Apr-Jun
TI  - Enrolment and retention of African women in biomedical research: the challenges.
PG  - 132-5
AB  - BACKGROUND: In Africa, women have had minimal participation in biomedical
      research especially in clinical trials despite the epidemiologic realities of the
      trends and burden of diseases in the continent. The purpose of this paper is to
      critically examine the challenges as well as suggesting ways of over-coming them 
      in recruiting and retaining African women in biomedical research. METHODS:
      Relevant biomedical research literatures on Human Research Participants from
      Scirus, Pubmed and Medline computerized search were critically evaluated and
      highlighted Information was also obtained from research ethics training as well
      as texts and journals in the medical libraries of the research ethics departments
      of the Universities of Pretoria, Kwazulu-Natal, Johns Hopkins Berman Institute of
      Bioethics Baltimore and Kennedy Institute of Bioethics Georgetown University,
      Washington DC. RESULTS: Studies reviewed have shown that African women have an
      unfair participation in biomedical research. Efforts in enrolling and retaining
      women in biomedical research are hampered by chain reactions of events viz:
      gender perception, cultural barriers, ignorance and fear of adverse event,
      limited autonomy to give consent, lack of confidentiality especially in sensitive
      trials, and improper research design. CONCLUSION: Women need to participate in
      clinical trials because of their different biological and physiological make-up
      which require proper information about the effects of drugs on their bodies. A
      variety of harm may therefore ensue from failure to include adequate numbers of
      women in biomedical research such as exposure to ineffective treatment,
      occurrence of unexpected side-effects and delayed diagnosis and early treatment
      of disease.
FAU - Chukwuneke, F N
AU  - Chukwuneke FN
AD  - Dept. of Oral and Maxillofacial Surgery, University of Nigeria Teaching Hospital,
      Enugu, South Africa. ichiefn2002@yahoo.com
FAU - Umeorah, O U J
AU  - Umeorah OU
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Nigeria
TA  - Niger J Med
JT  - Nigerian journal of medicine : journal of the National Association of Resident
      Doctors of Nigeria
JID - 100888321
SB  - IM
MH  - *Biomedical Research
MH  - Blacks/psychology
MH  - Clinical Trials as Topic/*psychology
MH  - *Culture
MH  - Female
MH  - Humans
MH  - Patient Acceptance of Health Care
MH  - *Patient Selection
MH  - Sex Factors
MH  - Women/*psychology
RF  - 14
EDAT- 2010/07/21 06:00
MHDA- 2010/08/20 06:00
CRDT- 2010/07/21 06:00
PHST- 2010/07/21 06:00 [entrez]
PHST- 2010/07/21 06:00 [pubmed]
PHST- 2010/08/20 06:00 [medline]
AID - 10.4314/njm.v19i2.56497 [doi]
PST - ppublish
SO  - Niger J Med. 2010 Apr-Jun;19(2):132-5. doi: 10.4314/njm.v19i2.56497.


PMID- 20642053
OWN - NLM
STAT- MEDLINE
DCOM- 20100816
LR  - 20190911
IS  - 0080-6234 (Print)
IS  - 0080-6234 (Linking)
VI  - 44
IP  - 2
DP  - 2010 Jun
TI  - [The meaning of sexual abuse in the manifestation of corporeity: a
      phenomenological study].
PG  - 401-6
AB  - This phenomenological study aimed at understanding the meaning of sexual abuse in
      the manifestation of corporeity. It was performed at an outpatient clinic for
      victims of sexual abuse from a teaching hospital in Curitiba/Brazil, from
      February to May of year 2007. The statements were obtained by means of recorded
      open interviews performed with nine women. The analysis resulted in the following
      theme: Living with fear in the process of co-existence. It was evidenced that
      fear influenced those women's social life, brought about insecurity, affected
      their being and their being in the world and, consequently, their corporeity.
      Health professionals must be qualified to perceive women victims of social abuse 
      in their multidimensionality so the care they deliver are not merely
      instrumental, rather expressive, that is, subjectively-oriented. Thus, they will 
      be able to help those victims transcend their experience and find a new meaning
      to their existence, and care delivery will be humanized, ethical and sympathetic.
FAU - Labronici, Liliana Maria
AU  - Labronici LM
AD  - Departamento de Enfermagem da Universidade Federal do Parana, PR, Brasil.
      lilibronici@yahoo.com.br
FAU - Fegadoli, Debora
AU  - Fegadoli D
FAU - Correa, Maria Eduarda Cavadinha
AU  - Correa ME
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Significado da violencia sexual na manifestacao da corporeidade: um estudo
      fenomenologico.
PL  - Brazil
TA  - Rev Esc Enferm USP
JT  - Revista da Escola de Enfermagem da U S P
JID - 0242726
MH  - Female
MH  - Human Body
MH  - Humans
MH  - Sex Offenses/*psychology
EDAT- 2010/07/21 06:00
MHDA- 2010/08/17 06:00
CRDT- 2010/07/21 06:00
PHST- 2010/07/21 06:00 [entrez]
PHST- 2010/07/21 06:00 [pubmed]
PHST- 2010/08/17 06:00 [medline]
AID - S0080-62342010000200023 [pii]
AID - 10.1590/s0080-62342010000200023 [doi]
PST - ppublish
SO  - Rev Esc Enferm USP. 2010 Jun;44(2):401-6. doi: 10.1590/s0080-62342010000200023.


PMID- 20641103
OWN - NLM
STAT- MEDLINE
DCOM- 20101215
LR  - 20100719
IS  - 1097-0347 (Electronic)
IS  - 1043-3074 (Linking)
VI  - 32
IP  - 8
DP  - 2010 Aug
TI  - Ethics of Frey syndrome: ensuring that consent is truly informed.
PG  - 1125-8
LID - 10.1002/hed.21443 [doi]
AB  - Frey syndrome is a widely recognized sequela of parotidectomy with a variable
      prevalence dependent upon diagnostic criteria. There exists a multitude of
      strategies for both prevention and treatment. Surgeons are obligated to engage
      patients in a frank and open discussion of the operative risks, benefits, and
      alternatives. Due to uncertainty regarding the significance of Frey syndrome
      postoperatively, the process of informed consent and preoperative decision-making
      pose a potential ethical quandary. This commentary is designed to heighten the
      awareness of the preoperative informed consent process by dissecting the ethical 
      tenets underlying these patient encounters using Frey syndrome as an example,
      ensuring that patients are granted the opportunity to participate in their own
      care in accordance with the concept of individual autonomy.
CI  - 2010 Wiley Periodicals, Inc. Head Neck, 2010.
FAU - Shuman, Andrew G
AU  - Shuman AG
AD  - Department of Otolaryngology - Head and Neck Surgery, University of Michigan
      Medical School, Ann Arbor, Michigan, USA. shumana@umich.edu
FAU - Bradford, Carol R
AU  - Bradford CR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Head Neck
JT  - Head & neck
JID - 8902541
SB  - IM
MH  - Decision Making/ethics
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Parotid Gland/*surgery
MH  - Personal Autonomy
MH  - Sweating, Gustatory/diagnosis/*etiology/therapy
EDAT- 2010/07/20 06:00
MHDA- 2010/12/16 06:00
CRDT- 2010/07/20 06:00
PHST- 2010/07/20 06:00 [entrez]
PHST- 2010/07/20 06:00 [pubmed]
PHST- 2010/12/16 06:00 [medline]
AID - 10.1002/hed.21443 [doi]
PST - ppublish
SO  - Head Neck. 2010 Aug;32(8):1125-8. doi: 10.1002/hed.21443.


PMID- 20639827
OWN - NLM
STAT- MEDLINE
DCOM- 20110223
LR  - 20161020
IS  - 1022-4742 (Print)
IS  - 1022-4742 (Linking)
VI  - 19
IP  - 3
DP  - 2010 Jul
TI  - Ethical awareness in surgical management.
PG  - 360-5
AB  - Getting information about disease has been suffering, the management needed,
      procedure and complication of that management, is the right of the patients.
      Giving that information to the patients is the responsibility of the
      physician/surgeons. The objective of this study was to assess the existing
      awareness of the surgeons and female patients regarding ethical issues of medical
      practices. This observational study was undertaken in the gynecological
      department of two tertiary hospital of the capital city of Bangladesh. One
      hundred fifty five patients were interviewed who were underwent surgical
      management for different gynecological problems. Mean age of the studied
      population was 41 (SD+/-10) years. All of them were from lower and lower middle
      economical classes. Sixty three percents (63%) were illiterate. Consent for the
      surgery was given by the husband in 52% cases, by son in 22% cases, by herself in
      1% case and remaining by other relatives. About 50% of the patients did not know 
      the name of their disease, 75% of them never talked with the surgeon. Only in 31%
      cases surgeon spontaneously explained them about her disease. Most of them had no
      knowledge about anaesthesia, operating time, need of blood transfusion, operating
      complications and long-term effects of the surgery they had. The result of this
      study showed very poor awareness about medical ethics and patient's right.
FAU - Khanam, N N
AU  - Khanam NN
AD  - Department of Obstetrics and Gynaecology, Bangabandhu Sheikh Mujib Medical
      University (BSMMU), Shahbagh, Dhaka, Bangladesh.
FAU - Alam, H
AU  - Alam H
FAU - Akhter, S
AU  - Akhter S
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - Bangladesh
TA  - Mymensingh Med J
JT  - Mymensingh medical journal : MMJ
JID - 9601799
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Bangladesh
MH  - Disclosure/ethics
MH  - Female
MH  - Gynecologic Surgical Procedures/*ethics
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Male
MH  - Middle Aged
MH  - Patient Rights/*ethics
MH  - Physician-Patient Relations/*ethics
MH  - Women's Rights/*ethics
EDAT- 2010/07/20 06:00
MHDA- 2011/02/24 06:00
CRDT- 2010/07/20 06:00
PHST- 2010/07/20 06:00 [entrez]
PHST- 2010/07/20 06:00 [pubmed]
PHST- 2011/02/24 06:00 [medline]
PST - ppublish
SO  - Mymensingh Med J. 2010 Jul;19(3):360-5.


PMID- 20639751
OWN - NLM
STAT- MEDLINE
DCOM- 20100927
LR  - 20220321
IS  - 1530-0293 (Electronic)
IS  - 0090-3493 (Linking)
VI  - 38
IP  - 9
DP  - 2010 Sep
TI  - A low-fidelity simulation curriculum addresses needs identified by faculty and
      improves the comfort level of senior internal medicine resident physicians with
      inhospital resuscitation.
PG  - 1899-903
LID - 10.1097/CCM.0b013e3181eb3ca9 [doi]
AB  - OBJECTIVE: The purpose of this study was to describe the essential elements of in
      hospital resuscitation knowledge and skills for senior internal medicine resident
      physicians and to evaluate a low-fidelity simulation course that incorporates
      these elements. DESIGN: In part 1, attending physicians were electronically
      surveyed using a modified Dillman method. A broad list of knowledge skills sets
      was gathered from recent resuscitation guidelines. In part 2, a 2-day,
      low-fidelity simulation, case-based curriculum was designed based on the results 
      of part 1. Course participants were surveyed 1 month before and 1 month after the
      course. SETTING: Four academic teaching hospitals. PARTICIPANTS: Attending
      physicians in cardiology, critical care, and internal medicine responded to the
      needs assessment survey. A convenience sample of internal medicine residents
      responded to the surveys before and after the course. MEASUREMENTS: Respondents
      ranked items on a 6-point Likert scale for all surveys. Responses were collated
      using descriptive statistics. This study met the requirements of the Research
      Ethics Board. MAIN RESULTS: In part 1, the response rate was 75% (n = 93), with
      the majority (52%) of respondents being internal medicine attending physicians.
      The top five knowledge sets were cardiac rhythm assessment, discussion of code
      status, delivery of bad news, management of wide complex tachycardia, and
      management of bradycardia. The top five skills were defibrillation, airway
      assessment, bag-mask ventilation, central venous access, and cardioversion. In
      part 2, the response rate was 93% (n = 27) before and 85% (n = 23) after course. 
      Only 28% of residents felt prepared to lead resuscitations before the course.
      After the course, 45% of participants reporting using the knowledge and skills
      during a resuscitation. Significant changes in median confidence scores before to
      after the course occurred in important domains. CONCLUSIONS: The results of the
      needs assessment should be used to tailor resuscitation education for residents. 
      An educational need exists for resident physicians. This low-fidelity simulation 
      course improves self-reported confidence in resuscitation knowledge and skills.
FAU - Healey, Andrew
AU  - Healey A
AD  - Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
      ahealey@sympatico.ca
FAU - Sherbino, Jonathan
AU  - Sherbino J
FAU - Fan, Jerome
AU  - Fan J
FAU - Mensour, Mark
AU  - Mensour M
FAU - Upadhye, Suneel
AU  - Upadhye S
FAU - Wasi, Parveen
AU  - Wasi P
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Crit Care Med
JT  - Critical care medicine
JID - 0355501
SB  - IM
CIN - Crit Care Med. 2010 Sep;38(9):1916-8. PMID: 20724893
MH  - *Clinical Competence
MH  - *Curriculum
MH  - Humans
MH  - *Internal Medicine
MH  - *Internship and Residency
MH  - *Medical Staff, Hospital
MH  - Needs Assessment
MH  - Program Evaluation
MH  - *Resuscitation
MH  - Workforce
EDAT- 2010/07/20 06:00
MHDA- 2010/09/29 06:00
CRDT- 2010/07/20 06:00
PHST- 2010/07/20 06:00 [entrez]
PHST- 2010/07/20 06:00 [pubmed]
PHST- 2010/09/29 06:00 [medline]
AID - 10.1097/CCM.0b013e3181eb3ca9 [doi]
PST - ppublish
SO  - Crit Care Med. 2010 Sep;38(9):1899-903. doi: 10.1097/CCM.0b013e3181eb3ca9.


PMID- 20639612
OWN - NLM
STAT- MEDLINE
DCOM- 20101025
LR  - 20101109
IS  - 1529-8795 (Electronic)
IS  - 0031-5982 (Linking)
VI  - 53
IP  - 3
DP  - 2010 Summer
TI  - Animal suffering should not trump environmental stewardship.
PG  - 458-70
LID - 10.1353/pbm.0.0172 [doi]
AB  - Andrew Linzey contends that our treatment of children should act as a model for
      our treatment of animals: just as we use our power to prevent the suffering of
      children, so should we restrict our behavior to protect animals from
      human-originated suffering. While not ignoring the role theology and emotion play
      in his ethical view, Linzey endeavors to provide a rational argument for the
      moral consideration of animals. In addition, Linzey explains how humans have
      created institutions to help them justify the continuance of animal suffering,
      followed by a plan to replace those institutions with animal-friendly ones.
      Linzey then applies his thinking to three contemporary institutions he believes
      cause animal suffering in an unjustifiable manner, namely hunting with dogs, fur 
      farming, and commercial sealing. This review offers a detailed account of several
      significant weaknesses of Linzey's argument, ranging from the theological to the 
      scientific, that should be considered before adopting his views.
FAU - Vantassel, Stephen M
AU  - Vantassel SM
AD  - School of Natural Resources, University of Nebraska-Lincoln, and King's
      Evangelical Divinity School (Distance Learning Office), Kent, United Kingdom.
      svantassel2@unl.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Perspect Biol Med
JT  - Perspectives in biology and medicine
JID - 0401132
SB  - IM
MH  - *Animal Rights
MH  - Animals
MH  - Bioethical Issues
MH  - Christianity
MH  - *Environment
MH  - Humans
MH  - *Morals
MH  - Pain/etiology/psychology
MH  - Stress, Psychological/etiology/psychology
EDAT- 2010/07/20 06:00
MHDA- 2010/10/26 06:00
CRDT- 2010/07/20 06:00
PHST- 2010/07/20 06:00 [entrez]
PHST- 2010/07/20 06:00 [pubmed]
PHST- 2010/10/26 06:00 [medline]
AID - S152987951030010X [pii]
AID - 10.1353/pbm.0.0172 [doi]
PST - ppublish
SO  - Perspect Biol Med. 2010 Summer;53(3):458-70. doi: 10.1353/pbm.0.0172.


PMID- 20639611
OWN - NLM
STAT- MEDLINE
DCOM- 20101025
LR  - 20101109
IS  - 1529-8795 (Electronic)
IS  - 0031-5982 (Linking)
VI  - 53
IP  - 3
DP  - 2010 Summer
TI  - Forty years later: the scope of bioethics revisited.
PG  - 452-7
LID - 10.1353/pbm.0.0170 [doi]
AB  - Two discrete conceptions of bioethics emerged in the 1970s: a holistic model that
      would "embrace within its scope long-range environmental concerns" versus a
      notion of bioethics that "would deal with concrete medical dilemmas." Although
      the latter has been the dominant perspective, Irina Pollard's new book Bioscience
      Ethics reintroduces a more global perspective of bioethics. This essay provides a
      cursory review of the different conceptions of bioethics and where Pollard's book
      fits in the controversy. It concludes by considering how some progress has been
      made to find a middle path that interprets bioethics more broadly as "the ethics 
      of the life sciences and health care."
FAU - Ross, Lainie Friedman
AU  - Ross LF
AD  - Departments of Medicine, Pediatrics, and Surgery, the College, and the MacLean
      Center for Clinical Medical Ethics, University of Chicago, Chicago IL 60637, USA.
      lross@uchicago.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Perspect Biol Med
JT  - Perspectives in biology and medicine
JID - 0401132
SB  - IM
MH  - *Bioethics
MH  - Humans
MH  - *Medicine in Literature
MH  - *Philosophy, Medical
MH  - United States
EDAT- 2010/07/20 06:00
MHDA- 2010/10/26 06:00
CRDT- 2010/07/20 06:00
PHST- 2010/07/20 06:00 [entrez]
PHST- 2010/07/20 06:00 [pubmed]
PHST- 2010/10/26 06:00 [medline]
AID - S1529879510300093 [pii]
AID - 10.1353/pbm.0.0170 [doi]
PST - ppublish
SO  - Perspect Biol Med. 2010 Summer;53(3):452-7. doi: 10.1353/pbm.0.0170.


PMID- 20639609
OWN - NLM
STAT- MEDLINE
DCOM- 20101025
LR  - 20101109
IS  - 1529-8795 (Electronic)
IS  - 0031-5982 (Linking)
VI  - 53
IP  - 3
DP  - 2010 Summer
TI  - Job and the stigmatization of chronic pain.
PG  - 425-38
LID - 10.1353/pbm.0.0166 [doi]
AB  - Many ethical and policy analyses of the devastating undertreatment of chronic
      pain leave unaddressed the role played by stigma, even though the notion that
      such stigma exists is well documented. This article examines the social and
      cultural roots of the stigma of chronic pain in American society. I document the 
      long history of illness stigma in Western societies as a way of illustrating the 
      power of this meaning-making construct, and I use the Book of Job as a framework 
      for understanding the deep link between sin and suffering in the context of
      illness and chronic pain in the United States. Unfortunately, while illness
      stigma can be ameliorated, there is little evidence of such progress in the
      undertreatment and stigmatization of chronic pain sufferers, and I explain some
      of the reasons why the best evidence does not demonstrate much improvement. I
      conclude by sketching some recommendations for diminishing the stigmatization of 
      the chronic pain sufferer, and warn that the focus on altering the opioid
      regulatory regime is unlikely to have the desired impact in reducing the
      suffering of millions of Americans.
FAU - Goldberg, Daniel S
AU  - Goldberg DS
AD  - Chronic Disease Prevention and Control Research Center, Department of Medicine,
      Baylor College of Medicine, 1709 Dryden, Suite 1025, Houston, TX 77030, USA.
      danielg@bcm.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Perspect Biol Med
JT  - Perspectives in biology and medicine
JID - 0401132
SB  - IM
MH  - *Bible
MH  - Chronic Disease
MH  - Humans
MH  - Pain/*psychology
MH  - Philosophy, Medical
MH  - Religion and Medicine
MH  - *Stereotyping
EDAT- 2010/07/20 06:00
MHDA- 2010/10/26 06:00
CRDT- 2010/07/20 06:00
PHST- 2010/07/20 06:00 [entrez]
PHST- 2010/07/20 06:00 [pubmed]
PHST- 2010/10/26 06:00 [medline]
AID - S152987951030007X [pii]
AID - 10.1353/pbm.0.0166 [doi]
PST - ppublish
SO  - Perspect Biol Med. 2010 Summer;53(3):425-38. doi: 10.1353/pbm.0.0166.


PMID- 20639608
OWN - NLM
STAT- MEDLINE
DCOM- 20101025
LR  - 20211020
IS  - 1529-8795 (Electronic)
IS  - 0031-5982 (Linking)
VI  - 53
IP  - 3
DP  - 2010 Summer
TI  - Making longevity in an aging society: linking Medicare policy and the new ethical
      field.
PG  - 407-24
LID - 10.1353/pbm.0.0164 [doi]
AB  - Life-extending interventions for older persons are changing medical knowledge and
      societal expectations about longevity. Today's consciousness about growing older 
      is partly shaped by a new form of ethics, constituted by and enabled through the 
      routines and institutions that comprise ordinary clinical care. Unlike bioethics,
      whose emphasis is on clinical decision-making in individual situations, this new 
      form of ethics is exceptionally diffuse and can be characterized as an ethical
      field. It is located in and shaped by health-care policies, standard
      technologies, and clinical evidence, and it emerges in what patients and families
      come to need and want. Three developments illustrate this ethical field at work: 
      the changing nature of disease, especially the ascent of risk awareness and
      risk-based strategies for life extension; the role of technology in reshaping the
      ends of medicine; and the role of Medicare policy in creating need and ethical
      necessity. Medicare's expanding criteria for payment coverage of liver
      transplantation and implantable cardiac devices illustrate the pervasive logic of
      this new form of ethics. The powerful connection between the technological
      imperative and its ethical necessity is rarely mentioned in Medicare reform
      debates.
FAU - Kaufman, Sharon R
AU  - Kaufman SR
AD  - Department of Anthropology, History and Social Medicine and Institute for Health 
      and Aging, University of California, San Francisco, CA 94143-0646, USA.
      sharon.kaufman@ucsf.edu
LA  - eng
GR  - R01 AG028426/AG/NIA NIH HHS/United States
GR  - R01 AG028426-04/AG/NIA NIH HHS/United States
GR  - R01 AG28426/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Perspect Biol Med
JT  - Perspectives in biology and medicine
JID - 0401132
SB  - IM
MH  - *Aging
MH  - Biomedical Technology/ethics
MH  - Defibrillators, Implantable
MH  - *Ethics
MH  - *Health Policy
MH  - Humans
MH  - Living Donors/ethics
MH  - *Longevity
MH  - Medicare/*organization & administration/standards
MH  - Organ Transplantation/ethics
MH  - Pacemaker, Artificial
MH  - Philosophy, Medical
MH  - Risk Assessment/ethics
MH  - United States
PMC - PMC3032593
MID - NIHMS265687
EDAT- 2010/07/20 06:00
MHDA- 2010/10/26 06:00
CRDT- 2010/07/20 06:00
PHST- 2010/07/20 06:00 [entrez]
PHST- 2010/07/20 06:00 [pubmed]
PHST- 2010/10/26 06:00 [medline]
AID - S1529879510300068 [pii]
AID - 10.1353/pbm.0.0164 [doi]
PST - ppublish
SO  - Perspect Biol Med. 2010 Summer;53(3):407-24. doi: 10.1353/pbm.0.0164.


PMID- 20639605
OWN - NLM
STAT- MEDLINE
DCOM- 20101025
LR  - 20211203
IS  - 1529-8795 (Electronic)
IS  - 0031-5982 (Linking)
VI  - 53
IP  - 3
DP  - 2010 Summer
TI  - Genomics and the conundrum of race: some epistemic and ethical considerations.
PG  - 357-72
LID - 10.1353/pbm.0.0171 [doi]
AB  - This article addresses the question of whether race is a biological category and 
      whether it is permissible to use it in biomedicine. I suggest that
      instrumentalism, a view that race is a problem-solving tool rather than a concept
      with an objective referent in nature, may be more consistent with the available
      scientific evidence. I argue that, to be morally permissible, the instrumentalist
      use of race in research and medicine requires stringent guidelines. I then
      provide four normative rules to guide race research in the biomedical sciences.
      The paper gathers evidence from philosophy of science, genomics, legal history,
      and normative ethics in order to ground the biomedical use of race in a
      converging ethical and epistemic framework.
FAU - Maglo, Koffi N
AU  - Maglo KN
AD  - Department of Philosophy, University of Cincinnati, 206 McMicken Hall,
      Cincinnati, OH 45221-0374, USA. maglokn@ucmail.uc.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Perspect Biol Med
JT  - Perspectives in biology and medicine
JID - 0401132
SB  - IM
MH  - *Bioethical Issues
MH  - *Genomics
MH  - Humans
MH  - Metagenomics
MH  - *Philosophy, Medical
MH  - Racial Groups/*genetics
MH  - Sociology, Medical
EDAT- 2010/07/20 06:00
MHDA- 2010/10/26 06:00
CRDT- 2010/07/20 06:00
PHST- 2010/07/20 06:00 [entrez]
PHST- 2010/07/20 06:00 [pubmed]
PHST- 2010/10/26 06:00 [medline]
AID - S1529879510300032 [pii]
AID - 10.1353/pbm.0.0171 [doi]
PST - ppublish
SO  - Perspect Biol Med. 2010 Summer;53(3):357-72. doi: 10.1353/pbm.0.0171.


PMID- 20639024
OWN - NLM
STAT- MEDLINE
DCOM- 20100824
LR  - 20100719
IS  - 1527-3792 (Electronic)
IS  - 0022-5347 (Linking)
VI  - 184
IP  - 2
DP  - 2010 Aug
TI  - Prospective evaluation of a single incision sling for stress urinary
      incontinence.
PG  - 604-9
LID - 10.1016/j.juro.2010.04.003 [doi]
AB  - PURPOSE: We report 12-month outcomes of the MiniArc single incision sling for
      stress urinary incontinence in women. MATERIALS AND METHODS: We performed a
      multicenter, prospective, single arm institutional review board/ethics committee 
      approved study evaluating the effectiveness of the MiniArc sling after
      implantation via qualitative (Urogenital Distress Inventory-Short Form and
      Incontinence Impact Questionnaire-Short Form) and quantitative (1-hour pad weight
      test and cough stress test) measurements. Secondary outcome measures included
      procedural variables (procedure time and estimated blood loss), length of stay,
      perioperative complications, Wong-Baker Faces Pain Scale and adverse events.
      RESULTS: A total of 188 women with a mean age of 51.1 +/- 10.6 years (median
      50.4, range 25.9 to 79.6) were enrolled in the study. At 1 year 157 patients were
      available for analysis. Mean procedure time, estimated blood loss and length of
      hospital stay were 11.0 +/- 6.7 minutes (median 10, range 2 to 55), 41.7 +/- 47.0
      ml (median 25, range 0 to 250) and 9.5 +/- 14.1 hours (median 3.2, range 0.5 to
      77.2), respectively. At discharge from hospital the mean Wong-Baker pain score
      was 1.3 +/- 2.0 (range 0.0 to 10.0). Of the patients 90.6% had a negative cough
      stress test and 84.5% had a 1-hour pad weight test less than 1 gm at 12 months.
      Median Urogenital Distress Inventory-Short Form and Incontinence Impact
      Questionnaire-Short Form scores showed a statistically significant decrease (p
      <0.001). Adverse events included urinary tract infection (4.3%), constipation
      (3.7%), temporary urinary retention (3.2%), dyspareunia (2.1%) and vaginal
      extrusion (1.6%). CONCLUSIONS: The MiniArc single incision sling is a safe and
      effective first line surgical procedure for the treatment of female stress
      urinary incontinence. It demonstrated excellent patient tolerability with minimal
      pain, early return to normal activity and low morbidity. In addition to sustained
      efficacy outcomes at 12 months patients treated with the MiniArc experienced a
      significant improvement in quality of life.
CI  - Copyright (c) 2010 American Urological Association Education and Research, Inc.
      Published by Elsevier Inc. All rights reserved.
FAU - Kennelly, Michael J
AU  - Kennelly MJ
AD  - McKay Urology Research, Charlotte, North Carolina, USA.
      michael.kennelly@carolinashealthcare.org
FAU - Moore, Robert
AU  - Moore R
FAU - Nguyen, John N
AU  - Nguyen JN
FAU - Lukban, James C
AU  - Lukban JC
FAU - Siegel, Steven
AU  - Siegel S
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20100619
PL  - United States
TA  - J Urol
JT  - The Journal of urology
JID - 0376374
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Prospective Studies
MH  - Prosthesis Design
MH  - *Suburethral Slings
MH  - Urinary Incontinence, Stress/*surgery
MH  - Urologic Surgical Procedures/methods
EDAT- 2010/07/20 06:00
MHDA- 2010/08/25 06:00
CRDT- 2010/07/20 06:00
PHST- 2010/01/04 00:00 [received]
PHST- 2010/07/20 06:00 [entrez]
PHST- 2010/07/20 06:00 [pubmed]
PHST- 2010/08/25 06:00 [medline]
AID - S0022-5347(10)03288-X [pii]
AID - 10.1016/j.juro.2010.04.003 [doi]
PST - ppublish
SO  - J Urol. 2010 Aug;184(2):604-9. doi: 10.1016/j.juro.2010.04.003. Epub 2010 Jun 19.


PMID- 20638577
OWN - NLM
STAT- MEDLINE
DCOM- 20101108
LR  - 20100719
IS  - 1557-9832 (Electronic)
IS  - 0272-2712 (Linking)
VI  - 30
IP  - 3
DP  - 2010 Sep
TI  - Cost-effectiveness of Down syndrome screening paradigms.
PG  - 629-42
LID - 10.1016/j.cll.2010.04.007 [doi]
AB  - Methodologic and ethical concerns in the area of prenatal diagnosis include
      whether the effects of such testing on individuals other than patients are
      considered, what assumptions are made regarding termination of pregnancy
      following a diagnosis, whether the redundancy of screening and diagnostic methods
      is considered, and how the impact of positive or negative screening results on
      patient experience and anxiety can be quantified. Several studies have examined
      the cost-effectiveness of screening for Down syndrome (DS). Given the current
      test characteristics, screening for DS is cost-effective across a wide variety of
      clinical situations. In fact, contingent screening is potentially a dominant
      strategy (costs less and leads to better outcomes). Understanding the methodology
      and salient issues of cost-effectiveness analysis is critical for researchers,
      editors, and clinicians to accurately interpret results of the growing body of
      cost-effectiveness studies in prenatal diagnosis.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Caughey, Aaron B
AU  - Caughey AB
AD  - Department of Obstetrics and Gynecology, 3181 SW Sam Jackson Park Road, Portland,
      OR 97239-3098, USA. abcmd@berkeley.edu
FAU - Kaimal, Anjali J
AU  - Kaimal AJ
FAU - Odibo, Anthony O
AU  - Odibo AO
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Clin Lab Med
JT  - Clinics in laboratory medicine
JID - 8100174
SB  - IM
MH  - Cost-Benefit Analysis
MH  - Down Syndrome/*diagnosis/economics
MH  - Female
MH  - Humans
MH  - Mass Screening/economics/methods
MH  - Pregnancy
MH  - Prenatal Diagnosis/*economics/methods
EDAT- 2010/07/20 06:00
MHDA- 2010/11/09 06:00
CRDT- 2010/07/20 06:00
PHST- 2010/07/20 06:00 [entrez]
PHST- 2010/07/20 06:00 [pubmed]
PHST- 2010/11/09 06:00 [medline]
AID - S0272-2712(10)00039-9 [pii]
AID - 10.1016/j.cll.2010.04.007 [doi]
PST - ppublish
SO  - Clin Lab Med. 2010 Sep;30(3):629-42. doi: 10.1016/j.cll.2010.04.007.


PMID- 20638552
OWN - NLM
STAT- MEDLINE
DCOM- 20100729
LR  - 20150616
IS  - 1474-547X (Electronic)
IS  - 0140-6736 (Linking)
VI  - 376
IP  - 9736
DP  - 2010 Jul 17
TI  - Germany: putting economics before ethics.
PG  - 142
LID - 10.1016/S0140-6736(10)61093-8 [doi]
LA  - eng
PT  - Editorial
PL  - England
TA  - Lancet
JT  - Lancet (London, England)
JID - 2985213R
SB  - IM
CIN - Lancet. 2010 Jul 17;376(9736):148-9. PMID: 20541253
MH  - Drug Costs/trends
MH  - Drug Industry/economics/ethics
MH  - Germany
MH  - Health Care Costs/ethics/*trends
MH  - Health Care Reform/*economics/*ethics
MH  - Humans
MH  - Income
MH  - Insurance, Health/*economics/ethics
MH  - Lobbying
MH  - *Politics
EDAT- 2010/07/20 06:00
MHDA- 2010/07/30 06:00
CRDT- 2010/07/20 06:00
PHST- 2010/07/20 06:00 [entrez]
PHST- 2010/07/20 06:00 [pubmed]
PHST- 2010/07/30 06:00 [medline]
AID - S0140-6736(10)61093-8 [pii]
AID - 10.1016/S0140-6736(10)61093-8 [doi]
PST - ppublish
SO  - Lancet. 2010 Jul 17;376(9736):142. doi: 10.1016/S0140-6736(10)61093-8.


PMID- 20637444
OWN - NLM
STAT- MEDLINE
DCOM- 20101025
LR  - 20181201
IS  - 1532-8481 (Electronic)
IS  - 8755-7223 (Linking)
VI  - 26
IP  - 4
DP  - 2010 Jul-Aug
TI  - The research program coordinator: an example of effective management.
PG  - 223-31
LID - 10.1016/j.profnurs.2009.12.002 [doi]
AB  - Careers in clinical research management are increasingly common. Despite nurses' 
      important role in clinical research, their status as research professionals is
      underrecognized. In this article, we describe the role of a "program coordinator"
      (PC) in the context of a complex research program on migration and reproductive
      health. The PC role expands beyond the usual role of a research coordinator
      because he or she is involved in all aspects of the program of research and his
      or her responsibilities include research, education, clinical, and administration
      components. He or she ensures optimal organization and continuity across several 
      studies and ensures ethical and scientific standards are applied for each
      individual study. His or her clinical knowledge assures data are accurate and
      subjects are safe. In addition, he or she assists with applying for funding, the 
      maintenance of research partnerships, and dissemination of research findings; he 
      or she supports students' learning and completes all regulatory aspects related
      to the program of research. Key to the PC role is relationship building and the
      application of Good Clinical Practice principles. The advanced role of a PC also 
      warrants opportunities for professional development and a competitive salary. A
      PC is an effective approach for research management and a natural role for
      professional nurse.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Merry, Lisa
AU  - Merry L
AD  - Migration and Reproductive Health Research Program (MiRHR), School of Nursing,
      McGill University, Montreal, Canada. lisa.merry@mcgill.ca
FAU - Gagnon, Anita J
AU  - Gagnon AJ
FAU - Thomas, Julia
AU  - Thomas J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Prof Nurs
JT  - Journal of professional nursing : official journal of the American Association of
      Colleges of Nursing
JID - 8511298
SB  - IM
MH  - *Biomedical Research/organization & administration
MH  - Canada
MH  - *Career Mobility
MH  - Humans
MH  - Nurse Administrators/economics/*organization & administration/*supply &
      distribution
MH  - *Reproductive Health Services/organization & administration
MH  - Salaries and Fringe Benefits
MH  - Transients and Migrants
MH  - Workforce
EDAT- 2010/07/20 06:00
MHDA- 2010/10/26 06:00
CRDT- 2010/07/20 06:00
PHST- 2006/02/28 00:00 [received]
PHST- 2010/07/20 06:00 [entrez]
PHST- 2010/07/20 06:00 [pubmed]
PHST- 2010/10/26 06:00 [medline]
AID - S8755-7223(09)00181-1 [pii]
AID - 10.1016/j.profnurs.2009.12.002 [doi]
PST - ppublish
SO  - J Prof Nurs. 2010 Jul-Aug;26(4):223-31. doi: 10.1016/j.profnurs.2009.12.002.


PMID- 20637343
OWN - NLM
STAT- MEDLINE
DCOM- 20100812
LR  - 20100719
IS  - 1879-1883 (Electronic)
IS  - 0002-9610 (Linking)
VI  - 200
IP  - 1
DP  - 2010 Jul
TI  - Virtual partnerships: aligning hospital and surgeon incentives.
PG  - 105-10
LID - 10.1016/j.amjsurg.2010.04.002 [doi]
AB  - BACKGROUND: Payment schemes exist for health care in the United States that are
      perverse and, in many cases, antithetical to the goals of all concerned. A
      fundamental reorganization will be required if care is to be broadened and
      sensible economies achieved. METHODS: For some time, we have experimented
      intellectually with reorganization of the specialist/hospital axis in
      contemporary medical care, seeking a more functional relationship among the
      parties (ie, doctors, nurses, hospitals, and their patients). RESULTS: A virtual 
      partnership between surgical specialists and the hospital provides many of the
      favored factors for productive and mutually respected care for patients with a
      feasible method for limiting costs. CONCLUSIONS: A virtual partnership, as
      exemplified for 3 major surgeries, could create a relationship that benefits the 
      patient, the surgical specialist, the hospital, and the ethical payer.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Fry, Donald E
AU  - Fry DE
AD  - Michael Pine and Associates, 5020 S. Lake Shore Drive, Chicago, IL 60615, USA.
      dfry@mpine-inc.com
FAU - Pine, Michael
AU  - Pine M
FAU - Pine, Gregory
AU  - Pine G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Surg
JT  - American journal of surgery
JID - 0370473
SB  - IM
MH  - *Cooperative Behavior
MH  - Economics, Hospital/*organization & administration
MH  - Health Care Costs
MH  - Hospital-Physician Joint Ventures/*organization & administration
MH  - Hospital-Physician Relations
MH  - Humans
MH  - Reimbursement, Incentive/*organization & administration
MH  - *Specialties, Surgical
MH  - United States
EDAT- 2010/07/20 06:00
MHDA- 2010/08/13 06:00
CRDT- 2010/07/20 06:00
PHST- 2010/04/01 00:00 [received]
PHST- 2010/04/16 00:00 [revised]
PHST- 2010/04/16 00:00 [accepted]
PHST- 2010/07/20 06:00 [entrez]
PHST- 2010/07/20 06:00 [pubmed]
PHST- 2010/08/13 06:00 [medline]
AID - S0002-9610(10)00167-4 [pii]
AID - 10.1016/j.amjsurg.2010.04.002 [doi]
PST - ppublish
SO  - Am J Surg. 2010 Jul;200(1):105-10. doi: 10.1016/j.amjsurg.2010.04.002.


PMID- 20637330
OWN - NLM
STAT- MEDLINE
DCOM- 20100812
LR  - 20100719
IS  - 1879-1883 (Electronic)
IS  - 0002-9610 (Linking)
VI  - 200
IP  - 1
DP  - 2010 Jul
TI  - Consensus statement on the adoption of the COPE guidelines.
PG  - 1
LID - 10.1016/j.amjsurg.2010.06.001 [doi]
AB  - We the undersigned editors of the member journals of the Surgery Journal Editors 
      Group (SJEG), in the furtherance of integrity in surgical and scientific
      publication, agree to adopt the guidelines established by the Committee on
      Publication Ethics (COPE). The COPE guidelines represent a means of addressing a 
      variety of ethical concerns, including duplicate publication and authorship
      misconduct issues, which have, unfortunately, become more prevalent.
CN  - Surgery Journal Editors Group
LA  - eng
PT  - Editorial
PL  - United States
TA  - Am J Surg
JT  - American journal of surgery
JID - 0370473
SB  - IM
MH  - *Editorial Policies
MH  - *Guideline Adherence
MH  - Guidelines as Topic
MH  - Humans
MH  - Periodicals as Topic/*ethics
MH  - *Scientific Misconduct
EDAT- 2010/07/20 06:00
MHDA- 2010/08/13 06:00
CRDT- 2010/07/20 06:00
PHST- 2010/07/20 06:00 [entrez]
PHST- 2010/07/20 06:00 [pubmed]
PHST- 2010/08/13 06:00 [medline]
AID - S0002-9610(10)00354-5 [pii]
AID - 10.1016/j.amjsurg.2010.06.001 [doi]
PST - ppublish
SO  - Am J Surg. 2010 Jul;200(1):1. doi: 10.1016/j.amjsurg.2010.06.001.


PMID- 20637140
OWN - NLM
STAT- MEDLINE
DCOM- 20110425
LR  - 20211028
IS  - 1741-203X (Electronic)
IS  - 1041-6102 (Linking)
VI  - 23
IP  - 2
DP  - 2011 Mar
TI  - The association between late-life cognitive test scores and retrospective
      informant interview data.
PG  - 274-9
LID - 10.1017/S1041610210001201 [doi]
AB  - BACKGROUND: Cognitive assessment of older persons, particularly those with
      impairment, is hampered by measurement error and the ethical issues of testing
      people with dementia. A potential source of valuable information about
      end-of-life cognitive status can be gained from those who knew the respondent
      well - mostly relatives or friends. This study tested the association between
      last cognitive assessment before death and a retrospective informant assessment
      of cognition. METHODS: Data were analyzed from 248 participants from the Medical 
      Research Council Cognitive Function and Ageing Study who were aged 71 to 102
      years at death. Late-life cognition was assessed 0 to 8 years before death using 
      the Mini-mental State Examination (MMSE) and the informant measure was taken 0 to
      7 years after death using a Retrospective Informant Interview (RInI). RESULTS:
      Zero-inflated Poisson regression showed a strong association between MMSE scores 
      and RInI scores - those scoring 29-30 on the MMSE had a RInI score four times
      lower than those who scored <18 (p < 0.001). The time between MMSE and death was 
      also a significant predictor with each additional year increasing RInI scores by 
      12.4% (p < 0.001). The time between death and RInI was only a significant
      predictor when including measures that were taken four years or more after death.
      CONCLUSIONS: Cognitive scores from retrospective informant interviews are
      strongly associated with late-life MMSE scores taken close to death. This
      suggests that the RInI can be used as a proxy measure of cognition in the period 
      leading up to death.
FAU - Marioni, Riccardo E
AU  - Marioni RE
AD  - Department of Public Health and Primary Care, University of Cambridge, Cambridge,
      UK. rem50@medschl.cam.ac.uk
FAU - Matthews, Fiona E
AU  - Matthews FE
FAU - Brayne, Carol
AU  - Brayne C
CN  - MRC Cognitive Function and Ageing Study
LA  - eng
GR  - G9901400/MRC_/Medical Research Council/United Kingdom
GR  - MC_U105292687/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
DEP - 20100719
PL  - England
TA  - Int Psychogeriatr
JT  - International psychogeriatrics
JID - 9007918
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cognition
MH  - Cognition Disorders/*diagnosis/psychology
MH  - Dementia/diagnosis/psychology
MH  - Female
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Neuropsychological Tests/standards
MH  - Poisson Distribution
MH  - Predictive Value of Tests
MH  - United Kingdom
EDAT- 2010/07/20 06:00
MHDA- 2011/04/26 06:00
CRDT- 2010/07/20 06:00
PHST- 2010/07/20 06:00 [entrez]
PHST- 2010/07/20 06:00 [pubmed]
PHST- 2011/04/26 06:00 [medline]
AID - S1041610210001201 [pii]
AID - 10.1017/S1041610210001201 [doi]
PST - ppublish
SO  - Int Psychogeriatr. 2011 Mar;23(2):274-9. doi: 10.1017/S1041610210001201. Epub
      2010 Jul 19.


PMID- 20637135
OWN - NLM
STAT- MEDLINE
DCOM- 20110104
LR  - 20220316
IS  - 1475-2662 (Electronic)
IS  - 0007-1145 (Linking)
VI  - 104
IP  - 11
DP  - 2010 Dec
TI  - The choice of biomarkers determines the selenium status in young German vegans
      and vegetarians.
PG  - 1601-4
LID - 10.1017/S0007114510002618 [doi]
AB  - Daily nutrition varies considerably among individuals. The number of vegetarians 
      is increasing continuously due to ethical, environmental, religious or other
      reasons. There is growing concern over their nutritional status with respect to
      micronutrient deficiencies. Among the essential trace elements, Se is of prime
      importance as it is part of the active site in selenoproteins. European soil and 
      plants are relatively poor sources of Se, while farm animals are generally
      supplemented with Se in order to improve their health and avoid deficiency
      syndromes. We therefore wondered whether German vegetarians display a measurable 
      Se deficiency. To this end, we compared young vegetarians (n 54) and omnivores (n
      53). We assessed their Se status by measuring extracellular glutathione
      peroxidase 3 (GPX3) activity, and concentrations of total serum Se and
      circulating Se-transport protein selenoprotein P (SEPP). GPX3 activities were not
      different between the groups, whereas both total Se and SEPP concentrations were 
      reduced to 79.5 and 71.2 % in vegetarians compared with omnivores. When splitting
      the group of vegetarians into vegans (n 26) and vegetarians consuming egg and
      milk products (n 28), analyses of the Se-dependent biomarkers did not reveal
      significant differences. We conclude that low serum Se is mirrored by circulating
      SEPP concentrations, but not by GPX3 activities in marginally supplied
      individuals. The specific dietary Se sources, divergent metabolic routes of
      selenomethionine v. selenocysteine and the different saturation kinetics of GPX3 
      and SEPP probably underlie our contradictory findings. Whether German vegetarians
      and vegans need to be considered as a Se-deficient group depends on the biomarker
      chosen.
FAU - Hoeflich, Johanna
AU  - Hoeflich J
AD  - Institute for Experimental Endocrinology, Charite-Universitatsmedizin Berlin,
      Berlin, Germany.
FAU - Hollenbach, Birgit
AU  - Hollenbach B
FAU - Behrends, Thomas
AU  - Behrends T
FAU - Hoeg, Antonia
AU  - Hoeg A
FAU - Stosnach, Hagen
AU  - Stosnach H
FAU - Schomburg, Lutz
AU  - Schomburg L
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100719
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
RN  - 0 (Biomarkers)
RN  - 0 (Selenoprotein P)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - H6241UJ22B (Selenium)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Deficiency Diseases/blood/*diagnosis
MH  - *Diet, Vegetarian
MH  - Female
MH  - Germany
MH  - Glutathione Peroxidase/*blood
MH  - Humans
MH  - Male
MH  - *Nutritional Status
MH  - Selenium/*blood/deficiency
MH  - Selenoprotein P/*blood
MH  - Young Adult
EDAT- 2010/07/20 06:00
MHDA- 2011/01/05 06:00
CRDT- 2010/07/20 06:00
PHST- 2010/07/20 06:00 [entrez]
PHST- 2010/07/20 06:00 [pubmed]
PHST- 2011/01/05 06:00 [medline]
AID - S0007114510002618 [pii]
AID - 10.1017/S0007114510002618 [doi]
PST - ppublish
SO  - Br J Nutr. 2010 Dec;104(11):1601-4. doi: 10.1017/S0007114510002618. Epub 2010 Jul
      19.


PMID- 20637068
OWN - NLM
STAT- MEDLINE
DCOM- 20100830
LR  - 20220309
IS  - 1476-069X (Electronic)
IS  - 1476-069X (Linking)
VI  - 9
DP  - 2010 Jul 16
TI  - Institutional review board challenges related to community-based participatory
      research on human exposure to environmental toxins: a case study.
PG  - 39
LID - 10.1186/1476-069X-9-39 [doi]
AB  - BACKGROUND: We report on the challenges of obtaining Institutional Review Board
      (IRB) coverage for a community-based participatory research (CBPR) environmental 
      justice project, which involved reporting biomonitoring and household exposure
      results to participants, and included lay participation in research. METHODS: We 
      draw on our experiences guiding a multi-partner CBPR project through university
      and state Institutional Review Board reviews, and other CBPR colleagues' written 
      accounts and conference presentations and discussions. We also interviewed
      academics involved in CBPR to learn of their challenges with Institutional Review
      Boards. RESULTS: We found that Institutional Review Boards are generally
      unfamiliar with CBPR, reluctant to oversee community partners, and resistant to
      ongoing researcher-participant interaction. Institutional Review Boards sometimes
      unintentionally violate the very principles of beneficence and justice which they
      are supposed to uphold. For example, some Institutional Review Boards refuse to
      allow report-back of individual data to participants, which contradicts the CBPR 
      principles that guide a growing number of projects. This causes significant
      delays and may divert research and dissemination efforts. Our extensive education
      of our university Institutional Review Board convinced them to provide human
      subjects protection coverage for two community-based organizations in our
      partnership. CONCLUSIONS: IRBs and funders should develop clear, routine review
      guidelines that respect the unique qualities of CBPR, while researchers and
      community partners can educate IRB staff and board members about the objectives, 
      ethical frameworks, and research methods of CBPR. These strategies can better
      protect research participants from the harm of unnecessary delays and exclusion
      from the research process, while facilitating the ethical communication of study 
      results to participants and communities.
FAU - Brown, Phil
AU  - Brown P
AD  - Brown University, Department of Sociology and Center for Environmental Studies,
      Box 1916, Providence, RI 02912, USA.
FAU - Morello-Frosch, Rachel
AU  - Morello-Frosch R
FAU - Brody, J G
AU  - Brody JG
FAU - Altman, Rebecca Gasior
AU  - Altman RG
FAU - Rudel, Ruthann A
AU  - Rudel RA
FAU - Senier, Laura
AU  - Senier L
FAU - Perez, Carla
AU  - Perez C
FAU - Simpson, Ruth
AU  - Simpson R
LA  - eng
GR  - 1 R25 ES013258-01/ES/NIEHS NIH HHS/United States
GR  - T15HL069792/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20100716
PL  - England
TA  - Environ Health
JT  - Environmental health : a global access science source
JID - 101147645
SB  - IM
MH  - California
MH  - *Community-Based Participatory Research/organization & administration
MH  - Environmental Exposure/adverse effects/*analysis
MH  - Ethics Committees, Research/*organization & administration
MH  - Humans
MH  - Information Dissemination
MH  - Massachusetts
PMC - PMC2914003
EDAT- 2010/07/20 06:00
MHDA- 2010/08/31 06:00
CRDT- 2010/07/20 06:00
PHST- 2009/12/15 00:00 [received]
PHST- 2010/07/16 00:00 [accepted]
PHST- 2010/07/20 06:00 [entrez]
PHST- 2010/07/20 06:00 [pubmed]
PHST- 2010/08/31 06:00 [medline]
AID - 1476-069X-9-39 [pii]
AID - 10.1186/1476-069X-9-39 [doi]
PST - epublish
SO  - Environ Health. 2010 Jul 16;9:39. doi: 10.1186/1476-069X-9-39.


PMID- 20636992
OWN - NLM
STAT- MEDLINE
DCOM- 20101025
LR  - 20151119
IS  - 1600-0846 (Electronic)
IS  - 0909-752X (Linking)
VI  - 16
IP  - 3
DP  - 2010 Aug
TI  - In vivo measurement of the human epidermal thickness in different localizations
      by multiphoton laser tomography.
PG  - 259-64
LID - 10.1111/j.1600-0846.2010.00437.x [doi]
AB  - BACKGROUND: The in vivo measurement of epidermal thickness is still challenging. 
      While ultrasound, optical coherence tomography and confocal laser microscopy are 
      used with moderate success, this issue has not been addressed by multiphoton
      laser tomography. OBJECTIVES: In the present study, an in vivo measurement of
      four different morphometric epidermal parameters is performed. METHODS: Thirty
      healthy volunteers aged 21-82 years were included in the study after informed
      consent and approval of the local ethics committee. At the dorsal forearm and the
      dorsum of the hand, the thicknesses of the total epidermis, viable epidermis and 
      stratum corneum and the depth of the papillary dermis were calculated from
      depth-resolved intensity curves after correlation with multiphoton images.
      RESULTS: We have shown consistently that in all age groups, the four morphometric
      parameters are significantly higher at the hand compared with the forearm, while 
      there were no differences between age groups. This is consistent with most
      previous findings. CONCLUSION: The method presented here provides a novel in vivo
      investigation tool for the measurement of epidermal morphometric parameters that 
      may be useful for the observation of epidermal changes over time in skin
      disorders, therapy side effects or in cosmetic science.
FAU - Koehler, Martin Johannes
AU  - Koehler MJ
AD  - Department of Dermatology and Allergology, Friedrich Schiller University, Jena,
      Germany. johannes.koehler@med.uni-jena.de
FAU - Vogel, Tanja
AU  - Vogel T
FAU - Elsner, Peter
AU  - Elsner P
FAU - Konig, Karsten
AU  - Konig K
FAU - Buckle, Rainer
AU  - Buckle R
FAU - Kaatz, Martin
AU  - Kaatz M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Skin Res Technol
JT  - Skin research and technology : official journal of International Society for
      Bioengineering and the Skin (ISBS) [and] International Society for Digital
      Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
JID - 9504453
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Algorithms
MH  - Dermoscopy/*instrumentation/methods
MH  - Epidermis/*anatomy & histology/*pathology
MH  - Forearm
MH  - Hand
MH  - Humans
MH  - *Lasers
MH  - Microscopy, Fluorescence, Multiphoton/*methods
MH  - Middle Aged
MH  - Skin Aging/*pathology
MH  - Young Adult
EDAT- 2010/07/20 06:00
MHDA- 2010/10/26 06:00
CRDT- 2010/07/20 06:00
PHST- 2010/07/20 06:00 [entrez]
PHST- 2010/07/20 06:00 [pubmed]
PHST- 2010/10/26 06:00 [medline]
AID - SRT437 [pii]
AID - 10.1111/j.1600-0846.2010.00437.x [doi]
PST - ppublish
SO  - Skin Res Technol. 2010 Aug;16(3):259-64. doi: 10.1111/j.1600-0846.2010.00437.x.


PMID- 20636592
OWN - NLM
STAT- MEDLINE
DCOM- 20101210
LR  - 20100719
IS  - 1365-2923 (Electronic)
IS  - 0308-0110 (Linking)
VI  - 44
IP  - 7
DP  - 2010 Jul
TI  - Ethical issues confronted by medical students during clinical rotations.
PG  - 723-30
LID - 10.1111/j.1365-2923.2010.03671.x [doi]
AB  - OBJECTIVES: This study aimed to examine the most common and important ethical
      issues confronting medical students during clinical rotations so that
      ethics-related topics can be prioritised according to students' needs and this
      information used to develop a curriculum for the ethics course. METHODS: In a
      cross-sectional approach, we reviewed the medical ethics-related cases recorded
      in the logbooks of all medical students (n=241) at Tehran University of Medical
      Sciences who attended the medical ethics course during October 2006 to July 2007.
      As part of a graded assignment, each student was required to record three
      encounters with ethics-related issues in his or her logbook. A total of 713 cases
      were assessed. Information related to the ethical issues and the conditions in
      which ethical issues arose was extracted and recorded by two experts, whose
      analysis showed agreement of kappa 0.77. In cases of discrepancy, both experts
      reviewed and discussed the record until they achieved agreement. RESULTS: A total
      of 713 cases were analysed. The most common issues reported by students related
      to ethics in medical education (20.1%, n=143), professionalism (18.8%, n=134),
      confidentiality (7.6%, n=54), the doctor-patient relationship (7.3%, n=52),
      informed consent (7.0%, n=50) and the doctor-peer relationship (7.0%, n=50).
      After adjusting for length of rotation, the highest numbers of ethics-related
      incidents were reported from urology, general surgery, orthopaedics, internal
      medicine, neurology, and obstetrics and gynaecology wards. CONCLUSIONS: The
      results of this study indicate that professionalism and related elements
      represent one of the most important areas of concern that need to be addressed
      when planning courses for medical students. The other significant area of concern
      is that of ethics in medical education, which, although the subject is not
      considered essential for medical practitioners, should be taught and respected so
      that student sensitivity to medical ethics is maintained and even increased.
FAU - Fard, Nazila Nikravan
AU  - Fard NN
AD  - Medical Ethics and History of Medicine Research Centre, Tehran University of
      Medical Sciences, and Department of Internal Medicine, Imam Khomeini Hospital
      Complex, Tehran, Iran.
FAU - Asghari, Fariba
AU  - Asghari F
FAU - Mirzazadeh, Azim
AU  - Mirzazadeh A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Med Educ
JT  - Medical education
JID - 7605655
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Clinical Clerkship/organization & administration
MH  - Cross-Sectional Studies
MH  - Education, Medical, Undergraduate/*ethics
MH  - *Ethics, Medical
MH  - Female
MH  - Humans
MH  - Informed Consent/ethics
MH  - Interprofessional Relations/ethics
MH  - Male
MH  - Personal Autonomy
MH  - Physician-Patient Relations/ethics
MH  - Professional Competence
MH  - Students, Medical/*psychology
EDAT- 2010/07/20 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/07/20 06:00
PHST- 2010/07/20 06:00 [entrez]
PHST- 2010/07/20 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - MED3671 [pii]
AID - 10.1111/j.1365-2923.2010.03671.x [doi]
PST - ppublish
SO  - Med Educ. 2010 Jul;44(7):723-30. doi: 10.1111/j.1365-2923.2010.03671.x.


PMID- 20636587
OWN - NLM
STAT- MEDLINE
DCOM- 20101210
LR  - 20220310
IS  - 1365-2923 (Electronic)
IS  - 0308-0110 (Linking)
VI  - 44
IP  - 7
DP  - 2010 Jul
TI  - International health electives: thematic results of student and professional
      interviews.
PG  - 683-9
LID - 10.1111/j.1365-2923.2010.03688.x [doi]
AB  - OBJECTIVES: The purpose of this study was to explore the complexities (including 
      harms and benefits) of international health electives (IHEs) involving medical
      trainees. This exploration contributes to the ongoing debate about the goals and 
      implications of IHEs for medical trainees. METHODS: This qualitative study used
      anonymous, one-to-one, semi-structured interviews. All participants had previous 
      international health experiences. Between September 2007 and March 2008, we
      interviewed a convenience sample of health care professionals (n=10) and medical 
      trainees (n=10). Using a modified grounded theory methodology, we carried out
      cycles of data analysis in conjunction with data collection in an iterative and
      constant comparison process. The study's thematic structure was finalised when
      theme saturation was achieved. RESULTS: Participants described IHEs in both
      negative and positive terms. IHEs were described as unsustained short-term
      contributions that lacked clear educational objectives and failed to address
      local community needs. Ethical dilemmas were described as IHE challenges.
      Participants reflected that many IHEs included aspects of medical tourism and the
      majority of participants described the IHE in negative terms. However, a few
      participants acknowledged the benefits of the IHE. Specifically, it was seen as
      an introduction to a career in global health and as a potential foundation for
      more sustainable projects with positive host community impacts. Finally, despite 
      similar understandings among participants, self-awareness of medical tourism was 
      low. CONCLUSIONS: International health electives may include potential harms and 
      benefits for both the trainee and the host community. Educational institutions
      should encourage and support structured IHEs for trainee participation. We
      recommend that faculties of medicine and global health educators establish
      pre-departure training courses for trainees and that IHE opportunities have
      sufficient structures in place to mitigate the negative effects of medical
      tourism. We also recommend that trainees be provided with opportunities to
      conduct self-reflection and critically assess their IHE experiences.
FAU - Petrosoniak, Andrew
AU  - Petrosoniak A
AD  - Division of Emergency Medicine, Department of Medicine, University of Toronto,
      Toronto, Ontario, Canada.
FAU - McCarthy, Anne
AU  - McCarthy A
FAU - Varpio, Lara
AU  - Varpio L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Med Educ
JT  - Medical education
JID - 7605655
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Education, Medical, Undergraduate/*organization & administration/*standards
MH  - Female
MH  - Humans
MH  - *International Educational Exchange
MH  - Male
MH  - Qualitative Research
MH  - Students, Medical/*psychology
MH  - Surveys and Questionnaires
EDAT- 2010/07/20 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/07/20 06:00
PHST- 2010/07/20 06:00 [entrez]
PHST- 2010/07/20 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - MED3688 [pii]
AID - 10.1111/j.1365-2923.2010.03688.x [doi]
PST - ppublish
SO  - Med Educ. 2010 Jul;44(7):683-9. doi: 10.1111/j.1365-2923.2010.03688.x.


PMID- 20636511
OWN - NLM
STAT- MEDLINE
DCOM- 20110307
LR  - 20151119
IS  - 1365-2834 (Electronic)
IS  - 0966-0429 (Linking)
VI  - 18
IP  - 5
DP  - 2010 Jul
TI  - Leading change: a challenge for leaders in Nordic health care.
PG  - 613-7
LID - 10.1111/j.1365-2834.2010.01097.x [doi]
AB  - AIMS: The aim of the present study was to describe personnel's attitudes to
      change processes between a regional hospital and the primary health care centre
      as well as investigate these results with regards to theories pertaining to
      change and leading change. BACKGROUND: Leadership has three crucial dimensions:
      focusing on personnel, results/key processes and the ethical base of activities. 
      METHODS: A survey was conducted in 2003 using a comprehensive questionnaire. The 
      total sample consisted of the personnel (n = 899) at the two organizations
      (answering rate was 68.8%). The data were analysed descriptively. RESULTS:
      Approximately two-thirds of the respondents understood why the merger was
      occurring. Only one-third expressed that they had received sufficient information
      regarding the merger. In total 67% felt that the merger would create conflict
      while approximately one-fourth expressed uncertainty. Despite such negative
      responses, approximately two-thirds felt there were advantages to the merger.
      Significant differences were seen between the groups. CONCLUSIONS: In times of
      change personnel expect leaders to focus on dialogue with their personnel and to 
      anchor the vision of the change process amongst the personnel. IMPLICATIONS FOR
      NURSING MANAGEMENT: By identifying the 'prison of thought' and creating an
      atmosphere where reflection and discussion are valued the nurse leader can help
      prevent resistance to change.
FAU - Fagerstrom, Lisbeth
AU  - Fagerstrom L
AD  - Health Sciences, Buskerud University College, Drammen 3045, Norway.
      lisbeth.fagerstrom@hibu.no
FAU - Salmela, Susanne
AU  - Salmela S
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Nurs Manag
JT  - Journal of nursing management
JID - 9306050
MH  - Health Care Surveys
MH  - Humans
MH  - *Leadership
MH  - Models, Nursing
MH  - Models, Organizational
MH  - Nurse Administrators
MH  - *Nursing, Supervisory
MH  - *Organizational Innovation
MH  - Primary Health Care
MH  - Scandinavian and Nordic Countries
MH  - Surveys and Questionnaires
MH  - Uncertainty
EDAT- 2010/07/20 06:00
MHDA- 2011/03/08 06:00
CRDT- 2010/07/20 06:00
PHST- 2010/07/20 06:00 [entrez]
PHST- 2010/07/20 06:00 [pubmed]
PHST- 2011/03/08 06:00 [medline]
AID - JNM1097 [pii]
AID - 10.1111/j.1365-2834.2010.01097.x [doi]
PST - ppublish
SO  - J Nurs Manag. 2010 Jul;18(5):613-7. doi: 10.1111/j.1365-2834.2010.01097.x.


PMID- 20635820
OWN - NLM
STAT- MEDLINE
DCOM- 20110421
LR  - 20220330
IS  - 1179-1942 (Electronic)
IS  - 0114-5916 (Linking)
VI  - 33
IP  - 8
DP  - 2010 Aug 1
TI  - Discourse on safe drug use: symbolic logics and ethical aspects.
PG  - 623-9
LID - 10.2165/11538320-000000000-00000 [doi]
AB  - Drug safety is not a matter for healthcare professionals alone. Patients are also
      involved, at three different levels: (i) in the behaviours patients adopt to
      reduce the adverse effects of the drugs; (ii) in regard to what some doctors say 
      to their patients about drug risks; and (iii) in what the pharmaceutical industry
      says about self-medication and risks. This article will examine these aspects on 
      the basis of information gathered in France during anthropological studies on
      drug use. (i) Patients' concerns about reducing adverse effects give rise to a
      series of behaviours relating to drug use. Patients start with the identification
      of what they regard as a risk inherent in the substances or linked to the
      uncontrolled use of drugs, and try to neutralize the risk by modifying or
      modulating the prescriptions in line with various parameters. Dimensions as
      varied as the nature of the prescribed drugs, the quantity, the dosage and the
      preservation of certain functions or organs are taken into account, and patients 
      follow their own rules of conduct in order to reduce risks. These dimensions
      bring into play characteristics of both the drug and the individual, and take
      into account the effects or the risks of drugs in their physical, psychic,
      behavioural and social aspects. (ii) Doctors' discourse towards patients
      regarding the risks and possible effects of drugs is examined, in particular the 
      discourse of those who choose to hide the undesirable effects of drugs from their
      patients with the aim of not jeopardizing the patient's compliance. This
      situation involves comparing two logics: ethics of care versus ethics of
      information. (iii) Regarding the pharmaceutical industry's discourse on
      self-medication and risks, although on the one hand it promotes self-medication
      on the basis of patients' growing desire for autonomy and competency, on the
      other hand it discourages the use of the home medicine cabinet for reasons of
      safety, which questions the ability of patients to use drugs properly. This
      article aims to demonstrate that the various behaviours and discourses relating
      to the risks of drugs are embedded with symbolic, ethical and cultural logics. As
      a consequence, above and beyond work carried out on the question of
      pharmacovigilance, examining the issue of safe drug use involves studying the
      human - social and cultural - aspects that govern part of the behaviours and
      practices relating to drug safety.
FAU - Fainzang, Sylvie
AU  - Fainzang S
AD  - CERMES, INSERM (National Institute of Health and Medical Research in France),
      Paris, France. sylvie.fainzang@orange.fr
LA  - eng
PT  - Journal Article
PT  - Review
PL  - New Zealand
TA  - Drug Saf
JT  - Drug safety
JID - 9002928
SB  - IM
MH  - Drug Industry/*ethics
MH  - Drug Therapy/ethics
MH  - *Drug-Related Side Effects and Adverse Reactions
MH  - Humans
MH  - *Patient Participation/methods
MH  - Physician-Patient Relations/*ethics
PMC - PMC3168863
MID - HALMS508397
OID - NLM: HALMS508397
EDAT- 2010/07/20 06:00
MHDA- 2011/04/22 06:00
CRDT- 2010/07/20 06:00
PHST- 2010/07/20 06:00 [entrez]
PHST- 2010/07/20 06:00 [pubmed]
PHST- 2011/04/22 06:00 [medline]
AID - 2 [pii]
AID - 10.2165/11538320-000000000-00000 [doi]
PST - ppublish
SO  - Drug Saf. 2010 Aug 1;33(8):623-9. doi: 10.2165/11538320-000000000-00000.


PMID- 20635591
OWN - NLM
STAT- MEDLINE
DCOM- 20100824
LR  - 20100719
IS  - 0353-9466 (Print)
IS  - 0353-9466 (Linking)
VI  - 49
IP  - 1
DP  - 2010 Mar
TI  - Medical expertise as a historical phenomenon and academic discipline.
PG  - 89-97
AB  - Based on secondary literature, a survey of particular forms of medical expertise 
      over history is presented. The state-to-individual interaction in terms of
      personality and physical integrity protection, health care, etc., was observed.
      It was only after the 16th century that the development of anatomy was found to
      have become a decisive argument for convincing expertise in various trials. In
      Croatia, the course of medical expertise development was comparable to the close 
      settings in the neighboring European countries. Major advances at the
      legislative, educational and professional levels took place in the second half of
      the 19th century. The subject of Forensic Medicine was introduced at Royal
      Academy of Jurisprudence as early as 1861; the book entitled Lecnicka izvesca
      (visa reperta) za prakticnu porabu lecnikov by Ivan Dezman (1841-1873) from 1868 
      offered the first systematic form of autopsy reports, whereas Kratka sudska
      medicina, a handbook in forensic medicine by Niko Selak (1861-1891) from 1889
      denoted the beginnings of forensic medicine literature in Croatian language. It
      has been noted that medical expertise approach perceives man as a social being at
      the crossing of manifold impacts and influences, thus being always observed by
      physicians of various specialties. During centuries, medical expertise has been
      formed in conjunction with advances in medicine and science, and with the
      development of civil society. Medical expertise had gradually grown into a
      multidisciplinary field requiring high professionalism, ethical approach,
      continuous training and collaboration with various professions. This resulted in 
      a compact and polyvalent discipline, in Croatia gradually formed as a special
      course in medical curriculum.
FAU - Gnjidic, Zivko
AU  - Gnjidic Z
AD  - University Department of Neurosurgery, Sestre milosrdnice University Hospital,
      Zagreb, Croatia. zgnjidic@kbsm.hr
FAU - Fatovic-Ferencic, Stella
AU  - Fatovic-Ferencic S
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - Croatia
TA  - Acta Clin Croat
JT  - Acta clinica Croatica
JID - 9425483
SB  - IM
MH  - Croatia
MH  - Europe
MH  - *Expert Testimony
MH  - Forensic Medicine/*history
MH  - History, 19th Century
MH  - History, 20th Century
MH  - History, Ancient
MH  - History, Medieval
MH  - Humans
MH  - Jurisprudence/history
EDAT- 2010/07/20 06:00
MHDA- 2010/08/25 06:00
CRDT- 2010/07/20 06:00
PHST- 2010/07/20 06:00 [entrez]
PHST- 2010/07/20 06:00 [pubmed]
PHST- 2010/08/25 06:00 [medline]
PST - ppublish
SO  - Acta Clin Croat. 2010 Mar;49(1):89-97.


PMID- 20635126
OWN - NLM
STAT- MEDLINE
DCOM- 20110405
LR  - 20211020
IS  - 1573-3645 (Electronic)
IS  - 1041-3545 (Linking)
VI  - 31
IP  - 4
DP  - 2010 Dec
TI  - The ethical imperative of medical humanities.
PG  - 267-77
LID - 10.1007/s10912-010-9118-0 [doi]
AB  - Medical humanities purchases its presence on the medical side of university
      campuses by adopting as its own the ends of medicine and medical ethics. It even 
      justifies its presence by asserting promotion of those ends as an ethical
      imperative, most of all to improve the caring in medical care. As
      unobjectionable, even praiseworthy, as this imperative appears, it actually
      constrains the possibilities for interpersonal relationship in the context of
      medical practice. Development of those possibilities requires openness of self to
      the existentially challenging ethical imperative to care also literally for
      nothing at all.
FAU - Rees, Geoffrey
AU  - Rees G
AD  - Department of Religion, Health, and Human Values, Rush University, 5339 South
      Cornell Avenue #2, Chicago, IL 60615, USA. rees.geoffrey@gmail.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Med Humanit
JT  - The Journal of medical humanities
JID - 8917478
SB  - IM
MH  - *Ethics, Medical
MH  - Humanities/*ethics
MH  - Humans
MH  - Interpersonal Relations
MH  - Love
MH  - Moral Obligations
MH  - Social Identification
EDAT- 2010/07/17 06:00
MHDA- 2011/04/06 06:00
CRDT- 2010/07/17 06:00
PHST- 2010/07/17 06:00 [entrez]
PHST- 2010/07/17 06:00 [pubmed]
PHST- 2011/04/06 06:00 [medline]
AID - 10.1007/s10912-010-9118-0 [doi]
PST - ppublish
SO  - J Med Humanit. 2010 Dec;31(4):267-77. doi: 10.1007/s10912-010-9118-0.


PMID- 20634030
OWN - NLM
STAT- MEDLINE
DCOM- 20110201
LR  - 20100830
IS  - 1769-6623 (Electronic)
IS  - 0750-7658 (Linking)
VI  - 29
IP  - 9
DP  - 2010 Sep
TI  - [Continuous epidural block versus continuous psoas compartment block for
      postoperative analgesia after major hip or femoral surgery in children: a
      prospective comparative randomized study].
PG  - 610-5
LID - 10.1016/j.annfar.2010.05.033 [doi]
AB  - BACKGROUND: Intravenous opioids and/or continuous epidural block (CEB) are used
      for postoperative analgesia after hip and/or femoral shaft surgery but adverse
      effects limit their use in children. A continuous psoas compartment block (CPCB),
      effective technique in adults can be an alternative. In this randomized
      comparative study, we wanted to evaluate CEB and CPCB in children after major hip
      surgery in terms of adverse events, pain relief and ropivacaine plasma
      concentrations. METHODS: After ethical committee and parents' approval, 40
      children scheduled for hip surgery were included and randomly allocated to
      receive CPCB or CEB. After general anaesthesia induction, 0.5 mL/kg of 0.375%
      ropivacaine were injected via the epidural or lumbar plexus catheter. After
      surgery, 0.1 ml/kg per hour (group CPCB) or 0.2 ml/kg per hour (group CEB) of
      0.2% ropivacaine was infused for 48h. Post-operative pain was evaluated using VAS
      or CHIPPS scores values at h1, h6, h12, h18, h24, h36 and h48, as well as doses
      of first line (paracetamol 15 mg/kg/6h) or second line rescue analgesia (0.2mg/kg
      intravenous nalbuphine), if pain score remained high after 30 mm. niflumic acid
      was systematically used. Adverse events were noted as well as parents'
      satisfaction at 48h. Ropivacaine plasma concentrations were measured four times
      up to 48h (h1, h6, h24 and h48) by high performance gas chromatography. RESULTS: 
      Forty children 1 to 12 years old (CPCB=20, CEB=20) were included. The demographic
      data were equivalent in both groups. Postoperative analgesia was excellent for
      both continuous block techniques during the whole studied period. Doses of rescue
      analgesics were comparable in both groups at the end of the 48h. Number of
      children who had at least one side effect is significantly higher in CEB group.
      Furthermore, the number of local anaesthetic premature stops was significantly
      more frequent in this group. Median values of ropivacaine plasma level in CEB
      group were significantly higher than CPCB group at h6 and h24. Ten parents in the
      CEB group and 15 in CPCB group were satisfied. CONCLUSION: Continuous psoas
      compartment block is an effective technique of postoperative analgesia after
      major hip or femoral surgery in children. It equally manages postoperative pain
      with significantly less adverse event and decreased ropivacaine doses and plasma 
      concentration than CEB.
CI  - Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
FAU - Dadure, C
AU  - Dadure C
AD  - Service d'anesthesie reanimation A, centre hospitalier universitaire Lapeyronie, 
      avenue du Doyen-Gaston-Giraud, Montpellier cedex 5, France.
      c-dadure@chu-montpellier.fr
FAU - Bringuier, S
AU  - Bringuier S
FAU - Mathieu, O
AU  - Mathieu O
FAU - Raux, O
AU  - Raux O
FAU - Rochette, A
AU  - Rochette A
FAU - Canaud, N
AU  - Canaud N
FAU - Javitary, W
AU  - Javitary W
FAU - Capdevila, X
AU  - Capdevila X
LA  - fre
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
PT  - Randomized Controlled Trial
TT  - Analgesie peridurale continue versus bloc continu du compartiment psoas pour
      l'analgesie postoperatoire apres chirurgie majeure du bassin ou du femur chez
      l'enfant : etude prospective comparative randomisee.
DEP - 20100714
PL  - France
TA  - Ann Fr Anesth Reanim
JT  - Annales francaises d'anesthesie et de reanimation
JID - 8213275
SB  - IM
MH  - *Analgesia, Epidural
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Femur/*surgery
MH  - Hip/*surgery
MH  - Humans
MH  - Infant
MH  - Male
MH  - *Nerve Block/methods
MH  - Orthopedic Procedures/*adverse effects
MH  - Pain, Postoperative/*etiology/*prevention & control
MH  - Prospective Studies
MH  - Psoas Muscles
EDAT- 2010/07/17 06:00
MHDA- 2011/02/02 06:00
CRDT- 2010/07/17 06:00
PHST- 2009/11/30 00:00 [received]
PHST- 2010/05/25 00:00 [accepted]
PHST- 2010/07/17 06:00 [entrez]
PHST- 2010/07/17 06:00 [pubmed]
PHST- 2011/02/02 06:00 [medline]
AID - S0750-7658(10)00257-1 [pii]
AID - 10.1016/j.annfar.2010.05.033 [doi]
PST - ppublish
SO  - Ann Fr Anesth Reanim. 2010 Sep;29(9):610-5. doi: 10.1016/j.annfar.2010.05.033.
      Epub 2010 Jul 14.


PMID- 20633939
OWN - NLM
STAT- MEDLINE
DCOM- 20101123
LR  - 20100827
IS  - 1873-1716 (Electronic)
IS  - 0167-5877 (Linking)
VI  - 96
IP  - 3-4
DP  - 2010 Sep 1
TI  - Multi Criteria Decision Making to evaluate control strategies of contagious
      animal diseases.
PG  - 201-10
LID - 10.1016/j.prevetmed.2010.06.010 [doi]
AB  - The decision on which strategy to use in the control of contagious animal
      diseases involves complex trade-offs between multiple objectives. This paper
      describes a Multi Criteria Decision Making (MCDM) application to illustrate its
      potential support to policy makers in choosing the control strategy that best
      meets all of the conflicting interests. The presented application focused on the 
      evaluation of alternative strategies to control Classical Swine Fever (CSF)
      epidemics within the European Union (EU) according to the preferences of the
      European Chief Veterinary Officers (CVO). The performed analysis was centred on
      the three high-level objectives of epidemiology, economics and social ethics. The
      appraised control alternatives consisted of the EU compulsory control strategy, a
      pre-emptive slaughter strategy, a protective vaccination strategy and a
      suppressive vaccination strategy. Using averaged preference weights of the
      elicited CVOs, the preference ranking of the control alternatives was determined 
      for six EU regions. The obtained results emphasized the need for EU
      region-specific control. Individual CVOs differed in their views on the relative 
      importance of the various (sub)criteria by which the performance of the
      alternatives were judged. Nevertheless, the individual rankings of the control
      alternatives within a region appeared surprisingly similar. Based on the results 
      of the described application it was concluded that the structuring feature of the
      MCDM technique provides a suitable tool in assisting the complex decision making 
      process of controlling contagious animal diseases.
CI  - 2010 Elsevier B.V. All rights reserved.
FAU - Mourits, M C M
AU  - Mourits MC
AD  - Department of Social Sciences, Business Economics, Wageningen University,
      Hollandseweg 1, 6706 KN Wageningen, The Netherlands. Monique.Mourits@wur.nl
FAU - van Asseldonk, M A P M
AU  - van Asseldonk MA
FAU - Huirne, R B M
AU  - Huirne RB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100714
PL  - Netherlands
TA  - Prev Vet Med
JT  - Preventive veterinary medicine
JID - 8217463
SB  - IM
MH  - Animal Husbandry/*methods
MH  - Animals
MH  - Classical Swine Fever/*prevention & control
MH  - *Decision Making
MH  - Disease Outbreaks/prevention & control/veterinary
MH  - Disease Transmission, Infectious/prevention & control/*veterinary
MH  - European Union
MH  - Euthanasia, Animal
MH  - Swine
EDAT- 2010/07/17 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/07/17 06:00
PHST- 2007/11/19 00:00 [received]
PHST- 2010/06/12 00:00 [revised]
PHST- 2010/06/15 00:00 [accepted]
PHST- 2010/07/17 06:00 [entrez]
PHST- 2010/07/17 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S0167-5877(10)00176-5 [pii]
AID - 10.1016/j.prevetmed.2010.06.010 [doi]
PST - ppublish
SO  - Prev Vet Med. 2010 Sep 1;96(3-4):201-10. doi: 10.1016/j.prevetmed.2010.06.010.
      Epub 2010 Jul 14.


PMID- 20633282
OWN - NLM
STAT- MEDLINE
DCOM- 20100907
LR  - 20211020
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 11
DP  - 2010 Jul 15
TI  - Experiences with community engagement and informed consent in a genetic cohort
      study of severe childhood diseases in Kenya.
PG  - 13
LID - 10.1186/1472-6939-11-13 [doi]
AB  - BACKGROUND: The potential contribution of community engagement to addressing
      ethical challenges for international biomedical research is well described, but
      there is relatively little documented experience of community engagement to
      inform its development in practice. This paper draws on experiences around
      community engagement and informed consent during a genetic cohort study in Kenya 
      to contribute to understanding the strengths and challenges of community
      engagement in supporting ethical research practice, focusing on issues of
      communication, the role of field workers in 'doing ethics' on the ground and the 
      challenges of community consultation. METHODS: The findings are based on action
      research methods, including analysis of community engagement documentation and
      the observations of the authors closely involved in their development and
      implementation. Qualitative and quantitative content analysis has been used for
      documentation of staff meetings and trainings, a meeting with 24 community
      leaders, and 40 large public and 70 small community group meetings. Meeting
      minutes from a purposive sample of six community representative groups have been 
      analysed using a thematic framework approach. RESULTS: Field workers described
      challenges around misunderstandings about research, perceived pressure for
      recruitment and challenges in explaining the study. During consultation, leaders 
      expressed support for the study and screening for sickle cell disease. In
      community meetings, there was a common interpretation of research as medical
      care. Concerns centred on unfamiliar procedures. After explanations of study
      procedures to leaders and community members, few questions were asked about
      export of samples or the archiving of samples for future research. CONCLUSIONS:
      Community engagement enabled researchers to take account of staff and community
      opinions and issues during the study and adapt messages and methods to address
      emerging ethical challenges. Field workers conducting informed consent faced
      complex issues and their understanding, attitudes and communication skills were
      key influences on ethical practice. Community consultation was a challenging
      concept to put into practice, illustrating the complexity of assessing
      information needs and levels of deliberation that are appropriate to a given
      study.
FAU - Marsh, Vicki M
AU  - Marsh VM
AD  - Kenya Medical Research Institute (KEMRI) Wellcome Trust Research Programme,
      Kilifi, Kenya. vmarsh@kilifi.kemri-wellcome.org
FAU - Kamuya, Dorcas M
AU  - Kamuya DM
FAU - Mlamba, Albert M
AU  - Mlamba AM
FAU - Williams, Thomas N
AU  - Williams TN
FAU - Molyneux, Sassy S
AU  - Molyneux SS
LA  - eng
GR  - GR074314MA/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100715
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Child
MH  - Cohort Studies
MH  - *Community Participation/methods/trends
MH  - Ethics, Research
MH  - Genetic Research/*ethics
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Kenya
MH  - Qualitative Research
MH  - Research Personnel
PMC - PMC2918624
EDAT- 2010/07/17 06:00
MHDA- 2010/09/08 06:00
CRDT- 2010/07/17 06:00
PHST- 2010/02/02 00:00 [received]
PHST- 2010/07/15 00:00 [accepted]
PHST- 2010/07/17 06:00 [entrez]
PHST- 2010/07/17 06:00 [pubmed]
PHST- 2010/09/08 06:00 [medline]
AID - 1472-6939-11-13 [pii]
AID - 10.1186/1472-6939-11-13 [doi]
PST - epublish
SO  - BMC Med Ethics. 2010 Jul 15;11:13. doi: 10.1186/1472-6939-11-13.


PMID- 20633241
OWN - NLM
STAT- MEDLINE
DCOM- 20110217
LR  - 20101004
IS  - 1467-9566 (Electronic)
IS  - 0141-9889 (Linking)
VI  - 32
IP  - 6
DP  - 2010 Sep
TI  - Ethical capital: 'what's a poor man got to leave?'.
PG  - 880-97
LID - 10.1111/j.1467-9566.2010.01246.x [doi]
AB  - For those of little or no means, leaving one's mark through financial assets,
      social connections, and human investment is difficult. Using secondary analysis
      of transcripts from face-to-face interviews with 33 terminally-ill patients from 
      an outpatient clinic at a public hospital serving the disadvantaged in the
      southern United States, we examine the legacy participants wish to leave behind. 
      As part of this process, participants assess life circumstances to try and
      generate a legacy allowing them to remain personally relevant to loved ones after
      death. For the low-SES terminally ill persons in this study, the desire to leave 
      a material legacy and the means to do so are not congruous. In the absence of
      economic resources to bequeath loved ones, participants describe their desire to 
      leave loved ones some form of ethical currency to facilitate interactions with
      others and protect them against social marginalisation. We call this concept
      ethical capital. We then argue ethical capital is a way for disadvantaged people 
      to find dignity and to affirm their lives.
CI  - (c) 2010 The Authors. Journal compilation (c) 2010 Foundation for the Sociology
      of Health & Illness/Blackwell Publishing Ltd.
FAU - Williams, Beverley
AU  - Williams B
AD  - Department of Veterans' Affairs, Birmingham VA Medical Center, USA.
FAU - Woodby, Lesa
AU  - Woodby L
FAU - Drentea, Patricia
AU  - Drentea P
LA  - eng
PT  - Journal Article
DEP - 20100713
PL  - England
TA  - Sociol Health Illn
JT  - Sociology of health & illness
JID - 8205036
SB  - IM
MH  - Adaptation, Psychological
MH  - Adult
MH  - Aged
MH  - *Attitude to Death
MH  - *Ethics, Medical
MH  - Female
MH  - Hospitals, Public
MH  - Humans
MH  - *Intergenerational Relations
MH  - Interview, Psychological
MH  - Male
MH  - Middle Aged
MH  - Outpatients
MH  - Poverty/*psychology
MH  - Psychometrics
MH  - Socioeconomic Factors
MH  - *Stress, Psychological
MH  - Tape Recording
MH  - Time Factors
MH  - United States
MH  - Wills/*ethics
MH  - Young Adult
EDAT- 2010/07/17 06:00
MHDA- 2011/02/18 06:00
CRDT- 2010/07/17 06:00
PHST- 2010/07/17 06:00 [entrez]
PHST- 2010/07/17 06:00 [pubmed]
PHST- 2011/02/18 06:00 [medline]
AID - SHIL1246 [pii]
AID - 10.1111/j.1467-9566.2010.01246.x [doi]
PST - ppublish
SO  - Sociol Health Illn. 2010 Sep;32(6):880-97. doi: 10.1111/j.1467-9566.2010.01246.x.
      Epub 2010 Jul 13.


PMID- 20633077
OWN - NLM
STAT- MEDLINE
DCOM- 20101025
LR  - 20100716
IS  - 1365-2850 (Electronic)
IS  - 1351-0126 (Linking)
VI  - 17
IP  - 6
DP  - 2010 Aug
TI  - Re-searching for therapy: the ethics of using what we are skilled in.
PG  - 503-9
LID - 10.1111/j.1365-2850.2009.01545.x [doi]
AB  - Narrative inquiry as a qualitative research method appears to be growing in
      popularity among mental health nurses. This paper argues that there are a number 
      of parallels between narrative inquiry and psychotherapy, and mental health
      nurses familiar with the practice of therapeutic engagement need to be mindful of
      these when using this approach to research. The symbiotic relationship between
      those engaged in narrative inquiry and those engaged in psychotherapeutic
      practice is explored in order to provide greater understanding of some of the
      ethical issues involved and how new researchers, supervisors and practitioners
      might better respond to the complexities inherent in using narrative inquiry
      which may itself be therapeutic. Our focus for this paper is the tensions
      experienced by the mental health nurse while working as a researcher when the
      research encounter provides a trigger that would normally elicit a therapeutic
      response for both participant and nurse. Using a selection of psychoanalytic
      theories and principles this paper explores the relationship between the
      processes of psychotherapy and narrative inquiry. This discussion paper is based 
      on the authors' own research experiences of using narrative inquiry to explore a 
      number of sensitive issues and many years of supervisory relationships with
      students and practitioners alike.
FAU - Warne, T
AU  - Warne T
AD  - School of Nursing, University of Salford, Salford, Greater Manchester, UK.
      A.R.Warne@Salford.ac.uk
FAU - McAndrew, S
AU  - McAndrew S
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Psychiatr Ment Health Nurs
JT  - Journal of psychiatric and mental health nursing
JID - 9439514
MH  - *Ethics, Nursing
MH  - Humans
MH  - Mental Disorders/*nursing
MH  - *Narration
MH  - Nurse's Role
MH  - Nursing Methodology Research/methods
MH  - Psychiatric Nursing/*ethics/methods
EDAT- 2010/07/17 06:00
MHDA- 2010/10/26 06:00
CRDT- 2010/07/17 06:00
PHST- 2010/07/17 06:00 [entrez]
PHST- 2010/07/17 06:00 [pubmed]
PHST- 2010/10/26 06:00 [medline]
AID - JPM1545 [pii]
AID - 10.1111/j.1365-2850.2009.01545.x [doi]
PST - ppublish
SO  - J Psychiatr Ment Health Nurs. 2010 Aug;17(6):503-9. doi:
      10.1111/j.1365-2850.2009.01545.x.


PMID- 20633063
OWN - NLM
STAT- MEDLINE
DCOM- 20110328
LR  - 20151119
IS  - 1445-5994 (Electronic)
IS  - 1444-0903 (Linking)
VI  - 40
IP  - 7
DP  - 2010 Jul
TI  - Palliative medicine trainees and their mandatory oncology module.
PG  - 530-3
LID - 10.1111/j.1445-5994.2010.02264.x [doi]
AB  - Palliative medicine trainees are currently required to complete 36 months of core
      and non-core training, including a 6-month oncology module. There are presently
      few published data from palliative medicine trainees regarding the structure and 
      appropriateness of their curriculum. The aim of this study was to evaluate skills
      related to the Royal Australasian College of Physicians essential learning
      objectives and the experiences gained by the individuals during their oncology
      training. An investigator-designed questionnaire was emailed out to all current
      Australasian trainees or first year consultants. A 45% response rate was
      achieved. Women were significantly more negative in their responses to the
      improvement of communication skills and the understanding of ethics. Chapter
      trainees rated improved leadership and future management skills lower than other 
      respondents. Fifty-eight per cent of the respondents believed the oncology module
      should remain mandatory. Although valuable, a more tailored and flexible approach
      to this part of training should be considered.
FAU - Landers, A
AU  - Landers A
AD  - Mary Potter Hospice, Wellington, New Zealand. amandalanders@paradise.net.nz
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Australia
TA  - Intern Med J
JT  - Internal medicine journal
JID - 101092952
SB  - IM
MH  - Australia
MH  - Female
MH  - Humans
MH  - *Internship and Residency/methods
MH  - Male
MH  - *Mandatory Programs
MH  - Medical Oncology/*education/methods
MH  - New Zealand
MH  - *Palliative Care/methods
MH  - Physicians
MH  - Surveys and Questionnaires
EDAT- 2010/07/17 06:00
MHDA- 2011/03/29 06:00
CRDT- 2010/07/17 06:00
PHST- 2010/07/17 06:00 [entrez]
PHST- 2010/07/17 06:00 [pubmed]
PHST- 2011/03/29 06:00 [medline]
AID - IMJ2264 [pii]
AID - 10.1111/j.1445-5994.2010.02264.x [doi]
PST - ppublish
SO  - Intern Med J. 2010 Jul;40(7):530-3. doi: 10.1111/j.1445-5994.2010.02264.x.


PMID- 20632860
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20131121
IS  - 1746-076X (Electronic)
IS  - 1746-0751 (Linking)
VI  - 5
IP  - 4
DP  - 2010 Jul
TI  - Regulatory considerations for the development of autologous induced pluripotent
      stem cell therapies.
PG  - 569-79
LID - 10.2217/rme.10.55 [doi]
AB  - Induced pluripotent stem (iPS) cells offer tremendous opportunity for the
      creation of autologous cellular therapies, in which gene correction or the
      avoidance of immune response issues are desirable. In addition, iPS cells avoid
      the ethical concerns raised by the sourcing of human embryonic stem cells (hESCs)
      from embryos. iPS cells share many characteristics with hESCs and it is
      anticipated that existing experience with hESCs will translate to rapid progress 
      in moving iPS cell-derived products toward clinical trials. While the potential
      clinical value for these products is considerable, the nature of current
      manufacturing paradigms for autologous iPS cell products raises considerable
      regulatory concerns. Here, the regulatory challenges posed by autologous iPS
      cell-derived products are examined. We conclude that there will be considerable
      regulatory concerns primarily relating to reproducibility of the manufacturing
      process and safety testing within clinically limited time constraints.
      Demonstrating safety of the final cell product in an autologous setting will be
      the single greatest obstacle to progressing autologous iPS cell-based therapies
      into the clinic.
FAU - Carpenter, Melissa K
AU  - Carpenter MK
AD  - Center for Applied Technology Development, Beckman Research Institute of City of 
      Hope, Duarte, CA, USA. m_carpenter@mac.com
FAU - Couture, Larry A
AU  - Couture LA
LA  - eng
PT  - Journal Article
PL  - England
TA  - Regen Med
JT  - Regenerative medicine
JID - 101278116
SB  - IM
MH  - *Cell- and Tissue-Based Therapy/ethics/standards/trends
MH  - Drug Industry/legislation & jurisprudence
MH  - Guidelines as Topic
MH  - *Health Policy
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*transplantation
MH  - *Tissue Engineering
MH  - United States
MH  - United States Food and Drug Administration/*legislation & jurisprudence
EDAT- 2010/07/17 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/07/17 06:00
PHST- 2010/07/17 06:00 [entrez]
PHST- 2010/07/17 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - 10.2217/rme.10.55 [doi]
PST - ppublish
SO  - Regen Med. 2010 Jul;5(4):569-79. doi: 10.2217/rme.10.55.


PMID- 20632857
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20141120
IS  - 1746-076X (Electronic)
IS  - 1746-0751 (Linking)
VI  - 5
IP  - 4
DP  - 2010 Jul
TI  - DNA methylation in cell differentiation and reprogramming: an emerging systematic
      view.
PG  - 531-44
LID - 10.2217/rme.10.35 [doi]
AB  - Embryonic stem cells have the unique ability to indefinitely self-renew and
      differentiate into any cell type found in the adult body. Differentiated cells
      can, in turn, be reprogrammed to embryonic stem-like induced pluripotent stem
      cells, providing exciting opportunities for achieving patient-specific stem cell 
      therapy while circumventing immunological obstacles and ethical controversies.
      Since both differentiation and reprogramming are governed by major changes in the
      epigenome, current directions in the field aim to uncover the epigenetic signals 
      that give pluripotent cells their unique properties. DNA methylation is one of
      the major epigenetic factors that regulates gene expression in mammals and is
      essential for establishing cellular identity. Recent analyses of pluripotent and 
      somatic cell methylomes have provided important insights into the extensive role 
      of DNA methylation during cell-fate commitment and reprogramming. In this
      article, the recent progress of differentiation and reprogramming research
      illuminated by high-throughput studies is discussed in the context of DNA
      methylation.
FAU - Huang, Kevin
AU  - Huang K
AD  - Department of Human Genetics, David Geffen School of Medicine, University of
      California Los Angeles, Los Angeles, CA 90095-7088, USA.
FAU - Fan, Guoping
AU  - Fan G
LA  - eng
GR  - R01 051411/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - England
TA  - Regen Med
JT  - Regenerative medicine
JID - 101278116
SB  - IM
MH  - Adult
MH  - *Cell Differentiation
MH  - Cellular Reprogramming/*genetics
MH  - *DNA Methylation
MH  - Embryonic Stem Cells/*physiology
MH  - Humans
EDAT- 2010/07/17 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/07/17 06:00
PHST- 2010/07/17 06:00 [entrez]
PHST- 2010/07/17 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - 10.2217/rme.10.35 [doi]
PST - ppublish
SO  - Regen Med. 2010 Jul;5(4):531-44. doi: 10.2217/rme.10.35.


PMID- 20632855
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20151119
IS  - 1746-076X (Electronic)
IS  - 1746-0751 (Linking)
VI  - 5
IP  - 4
DP  - 2010 Jul
TI  - Translational prospects for human induced pluripotent stem cells.
PG  - 509-19
LID - 10.2217/rme.10.39 [doi]
AB  - The pace of research on human induced pluripotent stem (iPS) cells is frantic
      worldwide, based on the enormous therapeutic potential of patient-specific
      pluripotent cells free of the ethical and political issues that plagued human
      embryonic stem cell research. iPS cells are now relatively easy to isolate from
      somatic cells and reprogramming can be accomplished using nonmutagenic
      technologies. Access to iPS cells is already paying dividends in the form of new 
      disease-in-a-dish models for drug discovery and as scalable sources of cells for 
      toxicology. For translation of cell therapies, the major advantage of iPS cells
      is that they are autologous, but for many reasons, perfect immunologic tolerance 
      of iPS-based grafts should not be assumed. This article focuses on the functional
      identity of iPS cells, anticipated safety and technical issues in their
      application, as well as a survey of the progress likely to be realized in
      clinical applications in the next decade.
FAU - Csete, Marie
AU  - Csete M
AD  - Research & Development, Organovo, Inc., 5871 Oberlin Dr #150, San Diego, CA
      92121, USA. mcsete@organovo.com
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Regen Med
JT  - Regenerative medicine
JID - 101278116
SB  - IM
MH  - Animals
MH  - *Drug Discovery
MH  - Humans
MH  - Induced Pluripotent Stem Cells/metabolism/*transplantation
MH  - Precision Medicine
MH  - *Tissue Engineering
EDAT- 2010/07/17 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/07/17 06:00
PHST- 2010/07/17 06:00 [entrez]
PHST- 2010/07/17 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - 10.2217/rme.10.39 [doi]
PST - ppublish
SO  - Regen Med. 2010 Jul;5(4):509-19. doi: 10.2217/rme.10.39.


PMID- 20632705
OWN - NLM
STAT- MEDLINE
DCOM- 20100818
LR  - 20100716
IS  - 1029-4864 (Print)
IS  - 1029-4864 (Linking)
VI  - 65
IP  - 4
DP  - 2010 May
TI  - Dental ethics case 1: What should I do when I suspect a child patient is being
      abused?
PG  - 184
FAU - Naidoo, S
AU  - Naidoo S
AD  - Department of Community Oral Health, University of the Western Cape, Private Bag 
      X1, Tygerberg, 7505. suenaidoo@uwc.ac.za
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - South Africa
TA  - SADJ
JT  - SADJ : journal of the South African Dental Association = tydskrif van die
      Suid-Afrikaanse Tandheelkundige Vereniging
JID - 9812497
MH  - Child
MH  - Child Abuse/*diagnosis/ethics/legislation & jurisprudence
MH  - Child Welfare/ethics/legislation & jurisprudence
MH  - Dentists/*ethics
MH  - *Ethics, Dental
MH  - Female
MH  - Humans
MH  - Mandatory Reporting/ethics
MH  - South Africa
EDAT- 2010/07/17 06:00
MHDA- 2010/08/19 06:00
CRDT- 2010/07/17 06:00
PHST- 2010/07/17 06:00 [entrez]
PHST- 2010/07/17 06:00 [pubmed]
PHST- 2010/08/19 06:00 [medline]
PST - ppublish
SO  - SADJ. 2010 May;65(4):184.


PMID- 20632155
OWN - NLM
STAT- MEDLINE
DCOM- 20101216
LR  - 20211020
IS  - 1563-258X (Electronic)
IS  - 0043-5341 (Linking)
VI  - 160
IP  - 9-10
DP  - 2010 May
TI  - [Homeopathy].
PG  - 256-8
LID - 10.1007/s10354-010-0780-7 [doi]
AB  - Even after 200 years, homeopathy has remained a highly disputed method. Its
      principles fly in the face of science. The totality of about 200 clinical trials 
      fails to demonstrate its efficacy beyond placebo. Its use as a benign placebo is 
      ethically unjustifiable. It follows that homeopathy cannot be recommended for use
      in medical routine.
FAU - Ernst, Edzard
AU  - Ernst E
AD  - Complementary Medicine, Peninsula Medical School, Universities of Exeter &
      Plymouth, Exeter, UK. Edzard.Ernst@pms.ac.uk
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Homoopathie.
PL  - Austria
TA  - Wien Med Wochenschr
JT  - Wiener medizinische Wochenschrift (1946)
JID - 8708475
SB  - IM
MH  - Adult
MH  - Child
MH  - Controlled Clinical Trials as Topic
MH  - Ethics, Medical
MH  - Homeopathy/adverse effects/ethics/*methods
MH  - Humans
MH  - Placebo Effect
EDAT- 2010/07/16 06:00
MHDA- 2010/12/17 06:00
CRDT- 2010/07/16 06:00
PHST- 2009/08/03 00:00 [received]
PHST- 2010/01/05 00:00 [accepted]
PHST- 2010/07/16 06:00 [entrez]
PHST- 2010/07/16 06:00 [pubmed]
PHST- 2010/12/17 06:00 [medline]
AID - 10.1007/s10354-010-0780-7 [doi]
PST - ppublish
SO  - Wien Med Wochenschr. 2010 May;160(9-10):256-8. doi: 10.1007/s10354-010-0780-7.


PMID- 20631591
OWN - NLM
STAT- MEDLINE
DCOM- 20110307
LR  - 20110825
IS  - 1932-8095 (Electronic)
IS  - 1932-8087 (Linking)
VI  - 15
IP  - 4
DP  - 2010 Jul-Aug
TI  - Speaking up in case management, part I: ethical and professional considerations.
PG  - 179-85; quiz 186-7
LID - 10.1097/NCM.0b013e3181e2d130 [doi]
AB  - OBJECTIVES: Case managers will occasionally witness colleagues from their own or 
      other healthcare disciplines providing care in ways that frankly deviate from or 
      violate standards of care, rules, regulations, policies, and procedures. This
      article will discuss the case manager's ethical obligation to speak up in such
      instances as well as list strategies illustrated in this article by a three-color
      flag system that classifies poor, better, and best responses to ethically
      challenging situations. PRIMARY PRACTICE SETTINGS: All case management work
      environments. FINDINGS/CONCLUSIONS: When health professionals practice in ways
      that deviate from established policies, procedures, rules, regulations, and
      standards of care, they jeopardize the safety and welfare of their clients and,
      often, their employing institutions. Although speaking up is often difficult due 
      to fears of retaliation or an organizational nonresponse, the fundamental ethical
      obligation of case managers is to protect and further their client's health and
      welfare rather than their professional self-interests. Consequently, the
      ethically conscientious case manager will pursue strategies whereby weaknesses or
      latent hazards that might compromise a client's care can be remediated.
      IMPLICATIONS FOR CASE MANAGEMENT PRACTICE: Because they practice in the midst of 
      multidisciplinary care, case managers have a marked opportunity to witness any
      number of practice standards being ignored or violated. Case managers need to
      cultivate a heightened moral awareness and response to such situations,
      especially when deviations from standards of care have become routine or
      "normalized." Critical elements in speaking up include cultivating a method to
      discern the moral perils of remaining silent, learning communication techniques
      to conduct emotionally challenging conversations, and building organizational
      leadership that recognizes the value of speaking up and supports safe harbors for
      employees who speak up appropriately.
FAU - Craig, Kathy
AU  - Craig K
AD  - Craig Research Continuum, LLC, 612 Third Street, Annapolis, MD 21403, USA.
      kdcraigrn@earthlink.net
FAU - Banja, John D
AU  - Banja JD
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Prof Case Manag
JT  - Professional case management
JID - 101291585
MH  - *Case Management
MH  - Certification
MH  - *Communication
MH  - *Ethics, Nursing
MH  - Humans
MH  - *Nurse's Role
MH  - Nursing Care/*methods
MH  - Organizational Culture
MH  - Patient Care/standards
MH  - Safety/standards
MH  - United States
EDAT- 2010/07/16 06:00
MHDA- 2011/03/08 06:00
CRDT- 2010/07/16 06:00
PHST- 2010/07/16 06:00 [entrez]
PHST- 2010/07/16 06:00 [pubmed]
PHST- 2011/03/08 06:00 [medline]
AID - 10.1097/NCM.0b013e3181e2d130 [doi]
AID - 01269241-201007000-00003 [pii]
PST - ppublish
SO  - Prof Case Manag. 2010 Jul-Aug;15(4):179-85; quiz 186-7. doi:
      10.1097/NCM.0b013e3181e2d130.


PMID- 20631457
OWN - NLM
STAT- MEDLINE
DCOM- 20110112
LR  - 20190513
IS  - 1348-9585 (Electronic)
IS  - 1341-9145 (Linking)
VI  - 52
IP  - 5
DP  - 2010
TI  - Confidentiality and physicians' health. A cross-sectional study of University
      Hospital Physicians in four European cities (the HOUPE-study).
PG  - 263-71
AB  - OBJECTIVE: To investigate how the subjective burden of confidentiality can act as
      a stressor that affects physicians' psychological health and wellbeing. METHOD:
      Cross-sectional survey data from a sample of university hospital physicians
      (N=1,956) in four European countries (Sweden, Norway, Iceland and Italy) who
      participated in the HOUPE (Health and Organization among University hospital
      Physicians in Europe) study was analysed. RESULTS: About 25% of the participants 
      reported that confidentiality impedes emotional support to a considerable degree.
      An index of confidentiality as a barrier to seeking support (ICBS) had a negative
      effect on physicians' health and wellbeing. The effect of ICBS was confirmed and 
      slightly increased when controlled for variables known to buffer the adverse
      mental and physical effects of stress. Though the physicians in Iceland and in
      Norway found confidentiality the most challenging, it was the physicians in Italy
      and Sweden who showed a significant effect of ICBS on their health and wellbeing.
      CONCLUSIONS: Whether confidentiality is a stressor in its own right or an
      amplifier of stressful situations in medical practice should be further
      investigated to gain a better understanding of the effect of confidentiality on
      physicians' coping, stress and health. In addition, there is a need to
      investigate how physicians can balance coping with the inevitable emotional
      demands of medical practice and maintaining the ethics of confidentiality in a
      way that protects both patients' privacy rights and physicians' health and
      wellbeing.
FAU - Lovseth, Lise Tevik
AU  - Lovseth LT
AD  - Department of Research and Development, Division of Psychiatry (AFFU), St Olavs
      University Hospital, Trondheim, Norway. lise.lovseth@ntnu.no
FAU - Aasland, Olaf Gjerlow
AU  - Aasland OG
FAU - Fridner, Ann
AU  - Fridner A
FAU - Jonsdottir, Lilja Sigrun
AU  - Jonsdottir LS
FAU - Marini, Massimo
AU  - Marini M
FAU - Linaker, Olav Morten
AU  - Linaker OM
LA  - eng
PT  - Journal Article
DEP - 20100712
PL  - Australia
TA  - J Occup Health
JT  - Journal of occupational health
JID - 9616320
SB  - IM
MH  - Adult
MH  - *Confidentiality
MH  - Cross-Sectional Studies
MH  - Emotions
MH  - Europe
MH  - Female
MH  - Health Status
MH  - Hospitals, University/statistics & numerical data
MH  - Humans
MH  - Interpersonal Relations
MH  - Male
MH  - Middle Aged
MH  - Physicians/ethics/*psychology
MH  - *Stress, Psychological
EDAT- 2010/07/16 06:00
MHDA- 2011/01/13 06:00
CRDT- 2010/07/16 06:00
PHST- 2010/07/16 06:00 [entrez]
PHST- 2010/07/16 06:00 [pubmed]
PHST- 2011/01/13 06:00 [medline]
AID - JST.JSTAGE/joh/L10014 [pii]
AID - 10.1539/joh.l10014 [doi]
PST - ppublish
SO  - J Occup Health. 2010;52(5):263-71. doi: 10.1539/joh.l10014. Epub 2010 Jul 12.


PMID- 20631029
OWN - NLM
STAT- MEDLINE
DCOM- 20101115
LR  - 20211020
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 95
IP  - 10
DP  - 2010 Oct
TI  - Glucocorticoids turn over slowly in human adipose tissue in vivo.
PG  - 4696-702
LID - 10.1210/jc.2010-0384 [doi]
AB  - CONTEXT: Lipophilic plasma glucocorticoids are thought to gain rapid access to
      intracellular compartments in adipose tissue. In other organs, transport can be
      regulated in a steroid- and tissue-specific manner. Moreover,
      11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) generates additional
      cortisol within adipose. AIM: The aim was to measure the rate of exchange of
      cortisol between plasma and adipose for comparison with rates of intracellular
      cortisol generation by 11betaHSD1. PARTICIPANTS AND INTERVENTIONS: With ethical
      approval, otherwise healthy females (n = 6) undergoing hysterectomy for benign
      indications were infused with tracer 9,11,12,12-[(2)H](4)cortisol (d4-cortisol). 
      Adipose biopsies and peripheral venous samples were obtained during surgery after
      3.9-5.5 h of infusion. Glucocorticoids were quantified using liquid
      chromatography tandem mass spectrometry. RESULTS: In plasma, d4-cortisol
      concentrations and appearance rates of cortisol and d3-cortisol (reflecting
      11betaHSD1 activity) did not change during surgery. In both omental and sc
      adipose, cortisol concentrations were lower than in plasma, consistent with
      differences in corticosteroid binding globulin, and enrichment with d4-cortisol
      was low (sc, 7.2 +/- 0.6%; omental, 7.4 +/- 0.7%; vs. plasma, 15.5 +/- 1.0%). The
      rate of accumulation of d4-cortisol in adipose depots was 0.5 +/- 0.1 (sc) and
      0.4 +/- 0.1 (omental) nmol/kg . h, and the proportion of intraadipose cortisol
      replaced each hour only 10.7 +/- 1.0 and 10.4 +/- 0.7%, respectively. The
      contribution of 11betaHSD1 to this turnover could not be quantified because very 
      little substrate d3-cortisone accumulated in adipose during infusion.
      CONCLUSIONS: Slow turnover of the adipose glucocorticoid pool suggests that rapid
      acute fluctuations in circulating cortisol are not reflected in adipose, so that 
      11betaHSD1 activity (previously estimated to generate 9 nmol cortisol/kg . h in
      sc adipose) may play a relatively important role in modulating activation of
      glucocorticoid receptors.
FAU - Hughes, Katherine A
AU  - Hughes KA
AD  - Centre for Cardiovascular Science, University of Edinburgh, Queen's Medical
      Research Institute, Edinburgh, United Kingdom.
FAU - Reynolds, Rebecca M
AU  - Reynolds RM
FAU - Andrew, Ruth
AU  - Andrew R
FAU - Critchley, Hilary O D
AU  - Critchley HO
FAU - Walker, Brian R
AU  - Walker BR
LA  - eng
GR  - RG/11/4/28734/BHF_/British Heart Foundation/United Kingdom
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100714
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Glucocorticoids)
RN  - EC 1.1.1.146 (11-beta-Hydroxysteroid Dehydrogenase Type 1)
RN  - V27W9254FZ (Cortisone)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - 11-beta-Hydroxysteroid Dehydrogenase Type 1/metabolism
MH  - Adipose Tissue/*metabolism/pathology
MH  - Adult
MH  - Cortisone/pharmacokinetics
MH  - Female
MH  - Glucocorticoids/blood/metabolism/*pharmacokinetics
MH  - Humans
MH  - Hydrocortisone/blood/metabolism/pharmacokinetics
MH  - Hysterectomy
MH  - Intraoperative Period
MH  - Middle Aged
MH  - Omentum/metabolism/pathology/surgery
MH  - Subcutaneous Fat/metabolism/pathology
MH  - Time Factors
PMC - PMC4394154
MID - EMS62855
OID - NLM: EMS62855
EDAT- 2010/07/16 06:00
MHDA- 2010/11/16 06:00
CRDT- 2010/07/16 06:00
PHST- 2010/07/16 06:00 [entrez]
PHST- 2010/07/16 06:00 [pubmed]
PHST- 2010/11/16 06:00 [medline]
AID - jc.2010-0384 [pii]
AID - 10.1210/jc.2010-0384 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2010 Oct;95(10):4696-702. doi: 10.1210/jc.2010-0384.
      Epub 2010 Jul 14.


PMID- 20630989
OWN - NLM
STAT- MEDLINE
DCOM- 20110310
LR  - 20220330
IS  - 1464-3685 (Electronic)
IS  - 0300-5771 (Linking)
VI  - 39
IP  - 5
DP  - 2010 Oct
TI  - DataSHIELD: resolving a conflict in contemporary bioscience--performing a pooled 
      analysis of individual-level data without sharing the data.
PG  - 1372-82
LID - 10.1093/ije/dyq111 [doi]
AB  - BACKGROUND: Contemporary bioscience sometimes demands vast sample sizes and there
      is often then no choice but to synthesize data across several studies and to
      undertake an appropriate pooled analysis. This same need is also faced in
      health-services and socio-economic research. When a pooled analysis is required, 
      analytic efficiency and flexibility are often best served by combining the
      individual-level data from all sources and analysing them as a single large data 
      set. But ethico-legal constraints, including the wording of consent forms and
      privacy legislation, often prohibit or discourage the sharing of individual-level
      data, particularly across national or other jurisdictional boundaries. This leads
      to a fundamental conflict in competing public goods: individual-level analysis is
      desirable from a scientific perspective, but is prevented by ethico-legal
      considerations that are entirely valid. METHODS: Data aggregation through
      anonymous summary-statistics from harmonized individual-level databases
      (DataSHIELD), provides a simple approach to analysing pooled data that
      circumvents this conflict. This is achieved via parallelized analysis and modern 
      distributed computing and, in one key setting, takes advantage of the properties 
      of the updating algorithm for generalized linear models (GLMs). RESULTS: The
      conceptual use of DataSHIELD is illustrated in two different settings.
      CONCLUSIONS: As the study of the aetiological architecture of chronic diseases
      advances to encompass more complex causal pathways-e.g. to include the joint
      effects of genes, lifestyle and environment-sample size requirements will
      increase further and the analysis of pooled individual-level data will become
      ever more important. An aim of this conceptual article is to encourage others to 
      address the challenges and opportunities that DataSHIELD presents, and to explore
      potential extensions, for example to its use when different data sources hold
      different data on the same individuals.
FAU - Wolfson, Michael
AU  - Wolfson M
AD  - Statistics Canada, Ottawa, Ontario, Canada.
FAU - Wallace, Susan E
AU  - Wallace SE
FAU - Masca, Nicholas
AU  - Masca N
FAU - Rowe, Geoff
AU  - Rowe G
FAU - Sheehan, Nuala A
AU  - Sheehan NA
FAU - Ferretti, Vincent
AU  - Ferretti V
FAU - LaFlamme, Philippe
AU  - LaFlamme P
FAU - Tobin, Martin D
AU  - Tobin MD
FAU - Macleod, John
AU  - Macleod J
FAU - Little, Julian
AU  - Little J
FAU - Fortier, Isabel
AU  - Fortier I
FAU - Knoppers, Bartha M
AU  - Knoppers BM
FAU - Burton, Paul R
AU  - Burton PR
LA  - eng
GR  - G0601625/MRC_/Medical Research Council/United Kingdom
GR  - FS/06/040/BHF_/British Heart Foundation/United Kingdom
GR  - 086160/Z/08/A/WT_/Wellcome Trust/United Kingdom
GR  - G0501942/MRC_/Medical Research Council/United Kingdom
GR  - G9815508/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100714
PL  - England
TA  - Int J Epidemiol
JT  - International journal of epidemiology
JID - 7802871
SB  - IM
MH  - Causality
MH  - Confidentiality
MH  - *Epidemiologic Methods
MH  - Ethics, Research
MH  - Humans
MH  - Information Storage and Retrieval/*methods
MH  - *Meta-Analysis as Topic
MH  - Research Design
PMC - PMC2972441
EDAT- 2010/07/16 06:00
MHDA- 2011/03/11 06:00
CRDT- 2010/07/16 06:00
PHST- 2010/07/16 06:00 [entrez]
PHST- 2010/07/16 06:00 [pubmed]
PHST- 2011/03/11 06:00 [medline]
AID - dyq111 [pii]
AID - 10.1093/ije/dyq111 [doi]
PST - ppublish
SO  - Int J Epidemiol. 2010 Oct;39(5):1372-82. doi: 10.1093/ije/dyq111. Epub 2010 Jul
      14.


PMID- 20630677
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20101004
IS  - 1872-7727 (Electronic)
IS  - 0720-048X (Linking)
VI  - 76
IP  - 1
DP  - 2010 Oct
TI  - Radiation protection: some philosophical and ethical issues.
PG  - 3-5
LID - 10.1016/j.ejrad.2010.06.030 [doi]
AB  - The ethical issue of justification has become an urgent issue in radiology. There
      has been a shift in emphasis in the discussion from what has been regarded as a
      rather paternalistic attitude of practitioners to one that stresses the rights of
      the individual patient. This article comments on this current move on the part of
      the profession by offering certain relevant philosophical considerations. Using a
      medical scenario as the context to comment on this shift, it discusses important 
      and fundamental issues, such as the autonomy and the rights of the patient in
      addition to the question of consent on the patient's part.
CI  - Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Sia, Santiago
AU  - Sia S
AD  - Faculty of Philosophy, Milltown Institute, Dublin, Ireland.
      ssia@milltown-institute.ie
FAU - Chhem, Rethy K
AU  - Chhem RK
FAU - Czarwinski, Renate
AU  - Czarwinski R
LA  - eng
PT  - Journal Article
DEP - 20100713
PL  - Ireland
TA  - Eur J Radiol
JT  - European journal of radiology
JID - 8106411
SB  - IM
MH  - Attitude of Health Personnel
MH  - Humans
MH  - Informed Consent/ethics
MH  - Morals
MH  - Patient Rights/*ethics
MH  - Personal Autonomy
MH  - *Philosophy, Medical
MH  - *Radiation Protection
MH  - Radiology/*ethics
EDAT- 2010/07/16 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/07/16 06:00
PHST- 2010/06/14 00:00 [received]
PHST- 2010/06/15 00:00 [accepted]
PHST- 2010/07/16 06:00 [entrez]
PHST- 2010/07/16 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - S0720-048X(10)00305-0 [pii]
AID - 10.1016/j.ejrad.2010.06.030 [doi]
PST - ppublish
SO  - Eur J Radiol. 2010 Oct;76(1):3-5. doi: 10.1016/j.ejrad.2010.06.030. Epub 2010 Jul
      13.


PMID- 20630643
OWN - NLM
STAT- MEDLINE
DCOM- 20110921
LR  - 20110613
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 72
IP  - 11
DP  - 2011 Jun
TI  - Making genetics not so important: family work in dealing with familial
      hypertrophic cardiomyopathy.
PG  - 1752-9
LID - 10.1016/j.socscimed.2010.06.012 [doi]
AB  - The literature shows that genetic testing could stimulate solidarity among family
      members, but also lead to major conflicts. To prevent negative effects, clinical 
      geneticists and ethicists have stressed the importance of 'good communication'
      within families. In this qualitative study, we followed six extended families in 
      the southern and eastern Netherlands involved in genetic testing for familial
      hypertrophic cardiomyopathy for three and a half years. In total 57 members of
      these families were interviewed in depth, most more than once. Our analysis shows
      that genetic testing does affect families, but that families perform a lot of
      'balancing work' in order to prevent genetic testing from becoming too
      all-encompassing. There is much more continuity in family life than is often
      thought. Moreover, as these families demonstrate different styles of family work,
      establishing a single norm of 'good communication' in clinical genetics might in 
      fact be more harmful for family life than genetic testing itself.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Geelen, Els
AU  - Geelen E
AD  - Department of Health Ethics and Society/Caphri, Faculty of Health, Medicine and
      Life Sciences, Maastricht University, Maastricht, the Netherlands.
      e.geelen@hes.unimaas.nl
FAU - Van Hoyweghen, Ine
AU  - Van Hoyweghen I
FAU - Horstman, Klasien
AU  - Horstman K
LA  - eng
PT  - Journal Article
DEP - 20100625
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Cardiomyopathy, Hypertrophic, Familial/*genetics
MH  - Communication
MH  - *Family Relations
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genetic Testing/*psychology
MH  - Humans
MH  - Male
MH  - Netherlands
MH  - Qualitative Research
EDAT- 2010/07/16 06:00
MHDA- 2011/09/22 06:00
CRDT- 2010/07/16 06:00
PHST- 2009/03/25 00:00 [received]
PHST- 2010/04/14 00:00 [revised]
PHST- 2010/06/14 00:00 [accepted]
PHST- 2010/07/16 06:00 [entrez]
PHST- 2010/07/16 06:00 [pubmed]
PHST- 2011/09/22 06:00 [medline]
AID - S0277-9536(10)00478-8 [pii]
AID - 10.1016/j.socscimed.2010.06.012 [doi]
PST - ppublish
SO  - Soc Sci Med. 2011 Jun;72(11):1752-9. doi: 10.1016/j.socscimed.2010.06.012. Epub
      2010 Jun 25.


PMID- 20630416
OWN - NLM
STAT- MEDLINE
DCOM- 20101019
LR  - 20100715
IS  - 1552-5279 (Electronic)
IS  - 1552-5260 (Linking)
VI  - 6
IP  - 4
DP  - 2010 Jul
TI  - Priorities for research consortia on Alzheimer's disease.
PG  - 359-62
LID - 10.1016/j.jalz.2010.05.2017 [doi]
AB  - Coordination and harmonization of efforts between five major research consortia
      on Alzheimer's disease may increase our understanding of this condition and
      improve our therapeutic approaches. Specific opportunities include a registry for
      families with early onset dementia, a study registry, minimal data sets,
      validation of assessment tools and outcomes, update on ethical issues, resolution
      of methodological issues, new investigators training, longitudinal observation
      studies, prevention studies, and liaison with stakeholders such as Alzheimer
      Disease International.
CI  - Copyright 2010. Published by Elsevier Inc.
FAU - Gauthier, Serge
AU  - Gauthier S
AD  - McGill University, Montreal, Canada. serge.gauthier@mcill.ca
FAU - Garcia, Angela
AU  - Garcia A
FAU - Sano, Mary
AU  - Sano M
FAU - Robert, Philippe
AU  - Robert P
FAU - Senanarong, Vorapun
AU  - Senanarong V
FAU - Woodward, Michael
AU  - Woodward M
FAU - Brodaty, Henry
AU  - Brodaty H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Alzheimers Dement
JT  - Alzheimer's & dementia : the journal of the Alzheimer's Association
JID - 101231978
SB  - IM
MH  - Age of Onset
MH  - *Alzheimer Disease/prevention & control
MH  - Clinical Trials as Topic
MH  - Data Interpretation, Statistical
MH  - Ethics, Research
MH  - Humans
MH  - Longitudinal Studies
MH  - Randomized Controlled Trials as Topic
MH  - Registries
MH  - Reproducibility of Results
MH  - Research/*standards/*trends
MH  - Research Design
EDAT- 2010/07/16 06:00
MHDA- 2010/10/20 06:00
CRDT- 2010/07/16 06:00
PHST- 2010/07/16 06:00 [entrez]
PHST- 2010/07/16 06:00 [pubmed]
PHST- 2010/10/20 06:00 [medline]
AID - S1552-5260(10)02137-0 [pii]
AID - 10.1016/j.jalz.2010.05.2017 [doi]
PST - ppublish
SO  - Alzheimers Dement. 2010 Jul;6(4):359-62. doi: 10.1016/j.jalz.2010.05.2017.


PMID- 20630335
OWN - NLM
STAT- MEDLINE
DCOM- 20101123
LR  - 20100715
IS  - 1873-4499 (Electronic)
IS  - 0899-7071 (Linking)
VI  - 34
IP  - 4
DP  - 2010 Jul-Aug
TI  - Renal hemodynamic changes with aging: a preliminary study using CT perfusion in
      the healthy elderly.
PG  - 247-50
LID - 10.1016/j.clinimag.2009.06.031 [doi]
AB  - OBJECTIVE: To investigate renal blood flow perfusion parameter changes associated
      with aging using multislice spiral computed tomography (CT). METHODS: This
      prospective study was approved by the institute's ethics committee for clinical
      study and written informed consent was obtained from all subjects. Forty-two
      consecutive patients who underwent abdominal CT without obvious renal abnormality
      at plain scanning were enrolled in this study. The renal perfusion scan was
      carried out using 16-slice spiral CT. The Pearson correlation coefficient was
      used to examine the correlation between perfusion parameter changes with aging.
      RESULTS: In both the cortex and medulla, blood flow (BF) and blood volume (BV)
      were negatively correlated with age, while time-to-peak (TTP) value and mean
      transit time (MTT) showed a positive correlation with age. Changes in BF, TTP,
      and MTT were found to have a statistically significant correlation with age in
      both the cortex and medulla, while the correlation between BV and age showed no
      statistical significance. CONCLUSION: It is feasible to assess renal hemodynamics
      changes with aging in the elderly using the current clinically available CT
      perfusion imaging technology in vivo. It may be helpful in the management of aged
      patients to familiarize with the renal hemodynamics changes in clinical work-up.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Zhao, Hong
AU  - Zhao H
AD  - Department of Radiology, The Fifth Affiliated Hospital of Zhongshan University,
      Zhuhai 519000, PR China.
FAU - Gong, Jingshan
AU  - Gong J
FAU - Wang, Yan
AU  - Wang Y
FAU - Zhang, Zuoquan
AU  - Zhang Z
FAU - Qin, Peixin
AU  - Qin P
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Imaging
JT  - Clinical imaging
JID - 8911831
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aging
MH  - Feasibility Studies
MH  - Female
MH  - *Hemodynamics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Renal Circulation/*physiology
MH  - Tomography, Spiral Computed
EDAT- 2010/07/16 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/07/16 06:00
PHST- 2009/05/28 00:00 [received]
PHST- 2009/06/05 00:00 [accepted]
PHST- 2010/07/16 06:00 [entrez]
PHST- 2010/07/16 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S0899-7071(09)00263-0 [pii]
AID - 10.1016/j.clinimag.2009.06.031 [doi]
PST - ppublish
SO  - Clin Imaging. 2010 Jul-Aug;34(4):247-50. doi: 10.1016/j.clinimag.2009.06.031.


PMID- 20629538
OWN - NLM
STAT- MEDLINE
DCOM- 20110411
LR  - 20151119
IS  - 1557-8534 (Electronic)
IS  - 1547-3287 (Linking)
VI  - 19
IP  - 11
DP  - 2010 Nov
TI  - Corneal stem cells and their origins: significance in developmental biology.
PG  - 1651-62
LID - 10.1089/scd.2010.0201 [doi]
AB  - Adult corneal stem cells (SCs) have been the subject of substantial research over
      the past 2 decades, with promising clinical applications being devised, refined, 
      and tried. However, there have been few studies on the early development of these
      cells in humans, perhaps due to ethical and practical constraints. This review
      highlights work that has yielded significant insights from developmental studies 
      in the cornea and other SC repositories. This field merits further research to
      improve our current knowledge of the origin of SCs, their location, phenotype,
      function, and niche structure, as well as providing fresh insight into the
      pathogenesis of congenital diseases and new therapeutic avenues for treating a
      range of blinding corneal diseases.
FAU - Davies, Sarah B
AU  - Davies SB
AD  - Department of Pathology, School of Medical Sciences, Inflammation and Infection
      Research Centre, The University of New South Wales, Sydney, Australia.
FAU - Di Girolamo, Nick
AU  - Di Girolamo N
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20101009
PL  - United States
TA  - Stem Cells Dev
JT  - Stem cells and development
JID - 101197107
RN  - 0 (Biomarkers)
SB  - IM
MH  - Biomarkers/metabolism
MH  - Cornea/*cytology/growth & development/physiology
MH  - Corneal Diseases/therapy
MH  - *Developmental Biology
MH  - Epithelial Cells/cytology/physiology
MH  - Fetus/anatomy & histology
MH  - Humans
MH  - Stem Cell Niche
MH  - Stem Cells/*cytology
EDAT- 2010/07/16 06:00
MHDA- 2011/04/13 06:00
CRDT- 2010/07/16 06:00
PHST- 2010/07/16 06:00 [entrez]
PHST- 2010/07/16 06:00 [pubmed]
PHST- 2011/04/13 06:00 [medline]
AID - 10.1089/scd.2010.0201 [doi]
PST - ppublish
SO  - Stem Cells Dev. 2010 Nov;19(11):1651-62. doi: 10.1089/scd.2010.0201. Epub 2010
      Oct 9.


PMID- 20629516
OWN - NLM
STAT- MEDLINE
DCOM- 20110103
LR  - 20100908
IS  - 1557-9034 (Electronic)
IS  - 1092-6429 (Linking)
VI  - 20
IP  - 7
DP  - 2010 Sep
TI  - Single-working-instrument, double-trocar, clipless cholecystectomy using harmonic
      scalpel: a feasible, safe, and less invasive technique.
PG  - 597-603
LID - 10.1089/lap.2009.0375 [doi]
AB  - AIM: The aim of this study was to evaluate the safety and efficacy of the
      Harmonic scalpel (Ethicon Endo-Surgery, Cincinnati, OH) in the closure/division
      of the cystic duct and artery, and bladder dissection in laparoscopic
      cholecystectomy as a single working instrument, with the use of a
      two-working-trocar technique, compared with the regular laparoscopic
      clip/cautery, three-trocar technique. METHODS: This prospective study included
      160 patients with symptomatic gallstone disease who were randomly assigned for
      laparoscopic cholecystectomy by either Harmonic shear as a single working
      instrument, with the two-trocar technique (group 1 = 80 patients) or group 2
      (regular clip/cautery, three-trocar technique) comprising 80 patients. RESULTS:
      No significant complications were encountered in either group; however, 1 case in
      the regular laparoscopy group suffered mild leakage that was treated
      conservatively. Intraoperative bile spillage was insignificantly comparable in
      both groups (10 versus 13%; P = 0.46). The median operative time was
      statistically significantly shorter in the Harmonic group (20 versus 45 minutes; 
      P = 0.0001). Also, hospital stay was significantly shorter in the Harmonic group 
      (1 versus 1.5 days, respectively; P = 0.001), but no statistically significant
      difference was found in the incidence of postoperative complications. The overall
      cosmetic results and patient satisfaction was better in the Harmonic group.
      CONCLUSIONS: The Harmonic shear is as safe and effective as the clip/cautery
      technique in laparoscopic cholecystectomy in achieving hemobiliary stasis, with
      shorter operative time, especially if used solely as a working instrument. The
      two-trocar technique is safe, feasible, and provides better cosmetic results and 
      patient satisfaction.
FAU - Redwan, Alaa A
AU  - Redwan AA
AD  - General Surgery Department, Assuit University Hospitals, Faculty of Medicine,
      Assuit University , Assuit, Egypt. ProfAlaaRedwan@yahoo.com
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - J Laparoendosc Adv Surg Tech A
JT  - Journal of laparoendoscopic & advanced surgical techniques. Part A
JID - 9706293
SB  - IM
MH  - Adult
MH  - Cholecystectomy, Laparoscopic/instrumentation
MH  - Cystic Duct/*surgery
MH  - Female
MH  - Gallbladder/blood supply/surgery
MH  - Gallstones/*surgery
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Surgical Instruments
MH  - Treatment Outcome
MH  - Ultrasonic Therapy/instrumentation
MH  - Young Adult
EDAT- 2010/07/16 06:00
MHDA- 2011/01/05 06:00
CRDT- 2010/07/16 06:00
PHST- 2010/07/16 06:00 [entrez]
PHST- 2010/07/16 06:00 [pubmed]
PHST- 2011/01/05 06:00 [medline]
AID - 10.1089/lap.2009.0375 [doi]
PST - ppublish
SO  - J Laparoendosc Adv Surg Tech A. 2010 Sep;20(7):597-603. doi:
      10.1089/lap.2009.0375.


PMID- 20629506
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20101008
LR  - 20100715
IS  - 1744-8352 (Electronic)
IS  - 1473-7159 (Linking)
VI  - 10
IP  - 5
DP  - 2010 Jul
TI  - Utility and efficacy of TGFBI mutational analysis for disease detection.
PG  - 569-73
LID - 10.1586/erm.10.51 [doi]
AB  - Current knowledge of the genetic variation associated with TGFBI-associated
      corneal dystrophies has highlighted the possibility of de novo mutations, and
      also recurrence after refractive surgery in apparently asymptomatic individuals. 
      This means that genetic testing for the most common variants is considered
      desirable, particularly in the refractive clinical setting. To be a useful
      clinical adjunct, however, genetic testing must be time and cost effective. Yoo
      and coworkers propose a nanoparticle microarray for rapid detection of TGFBI
      mutations. The advantages and limitations of these nanoparticle microarrays need 
      to be compared with current methods of mutation detection. Clinicians should
      include genetic testing in the clinical work-up, and must consider the ethical
      principles of making a genetic diagnosis, as well as the marked variance in
      clinical presentation in this group of dystrophies.
FAU - Vincent, Andrea L
AU  - Vincent AL
AD  - Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical 
      and Health Sciences, University of Auckland, Auckland, New Zealand.
      a.vincent@auckland.ac.nz
FAU - Sherwin, Trevor
AU  - Sherwin T
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - England
TA  - Expert Rev Mol Diagn
JT  - Expert review of molecular diagnostics
JID - 101120777
CON - Anal Chem. 2010 Feb 15;82(4):1349-57. PMID: 20092310
EDAT- 2010/07/16 06:00
MHDA- 2010/07/16 06:01
CRDT- 2010/07/16 06:00
PHST- 2010/07/16 06:00 [entrez]
PHST- 2010/07/16 06:00 [pubmed]
PHST- 2010/07/16 06:01 [medline]
AID - 10.1586/erm.10.51 [doi]
PST - ppublish
SO  - Expert Rev Mol Diagn. 2010 Jul;10(5):569-73. doi: 10.1586/erm.10.51.


PMID- 20629413
OWN - NLM
STAT- MEDLINE
DCOM- 20100803
LR  - 20211020
IS  - 1386-9620 (Print)
IS  - 1386-9620 (Linking)
VI  - 13
IP  - 2
DP  - 2010 Jun
TI  - Impact of e-detailing on the number of new prescriptions.
PG  - 101-11
AB  - The recent trend of e-detailing in the pharmaceutical industry aims to increase
      the effectiveness of promotion of prescription products to physicians at a less
      expensive way than traditional detailing. In the proposed promotion response
      model, the effect of e-detailing on new prescriptions is accounted for in the
      presence of traditional face-to-face detailing and a host of product-specific
      factors. The model is calibrated on 21 ethical pharmaceutical products in six
      diverse therapeutic categories over a period of two years using datasets from two
      industrial sources. We estimate our model once at the aggregate level and once
      using a fixed-effects methodology to account for unobserved heterogeneity across 
      products. We find that prescription product (Rx) manufacturers appear to benefit 
      from increasing both e-detailing and traditional detailing. Our findings also
      lead us to conclude that there is room for improving the synergy between the two 
      types of detailing.
FAU - Gonul, Fusun F
AU  - Gonul FF
AD  - School of Business, Slippery Rock University, Slippery Rock, PA 16057-1399, USA. 
      fusun.gonul@sru.edu
FAU - Carter, Franklin J
AU  - Carter FJ
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Health Care Manag Sci
JT  - Health care management science
JID - 9815649
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Databases as Topic
MH  - *Drug Industry
MH  - *Electronic Mail
MH  - Marketing/*methods
MH  - Models, Organizational
MH  - *Pharmaceutical Preparations
MH  - Practice Patterns, Physicians'
MH  - United States
EDAT- 2010/07/16 06:00
MHDA- 2010/08/04 06:00
CRDT- 2010/07/16 06:00
PHST- 2010/07/16 06:00 [entrez]
PHST- 2010/07/16 06:00 [pubmed]
PHST- 2010/08/04 06:00 [medline]
AID - 10.1007/s10729-009-9110-2 [doi]
PST - ppublish
SO  - Health Care Manag Sci. 2010 Jun;13(2):101-11. doi: 10.1007/s10729-009-9110-2.


PMID- 20629276
OWN - NLM
STAT- MEDLINE
DCOM- 20100803
LR  - 20100714
IS  - 0033-2658 (Print)
IS  - 0033-2658 (Linking)
VI  - 112
IP  - 5
DP  - 2010
TI  - [Clinical research on industrial mental health and industrial ethics: logical
      analysis of points of argument and suggestions on legislative steps].
PG  - 495-502
FAU - Kurihara, Chieko
AU  - Kurihara C
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Seishin Shinkeigaku Zasshi
JT  - Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica
JID - 9801787
SB  - IM
MH  - *Ethics, Business
MH  - Japan
MH  - *Mental Health
MH  - *Occupational Health
MH  - Research/legislation & jurisprudence
EDAT- 2010/07/16 06:00
MHDA- 2010/08/04 06:00
CRDT- 2010/07/16 06:00
PHST- 2010/07/16 06:00 [entrez]
PHST- 2010/07/16 06:00 [pubmed]
PHST- 2010/08/04 06:00 [medline]
PST - ppublish
SO  - Seishin Shinkeigaku Zasshi. 2010;112(5):495-502.


PMID- 20629264
OWN - NLM
STAT- MEDLINE
DCOM- 20100803
LR  - 20100714
IS  - 0033-2658 (Print)
IS  - 0033-2658 (Linking)
VI  - 112
IP  - 5
DP  - 2010
TI  - [Clinical studies on industrial mental health and industrial ethics--a
      coordinator's awareness of problems].
PG  - 466-71
FAU - Saio, Takeo
AU  - Saio T
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Seishin Shinkeigaku Zasshi
JT  - Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica
JID - 9801787
SB  - IM
MH  - Ethics, Business
MH  - Humans
MH  - *Mental Health
MH  - *Occupational Health
EDAT- 2010/07/16 06:00
MHDA- 2010/08/04 06:00
CRDT- 2010/07/16 06:00
PHST- 2010/07/16 06:00 [entrez]
PHST- 2010/07/16 06:00 [pubmed]
PHST- 2010/08/04 06:00 [medline]
PST - ppublish
SO  - Seishin Shinkeigaku Zasshi. 2010;112(5):466-71.


PMID- 20629196
OWN - NLM
STAT- MEDLINE
DCOM- 20101230
LR  - 20211020
IS  - 1552-4930 (Electronic)
IS  - 1552-4922 (Linking)
VI  - 77
IP  - 9
DP  - 2010 Sep
TI  - Correlation analysis of intracellular and secreted cytokines via the generalized 
      integrated mean fluorescence intensity.
PG  - 873-80
LID - 10.1002/cyto.a.20943 [doi]
AB  - The immune response in humans is usually assessed using immunogenicity assays to 
      provide biomarkers as correlates of protection (CoP). Flow cytometry is the assay
      of choice to measure intracellular cytokine staining (ICS) of cell-mediated
      immune (CMI) biomarkers. For CMI analysis, the integrated mean fluorescence
      intensity (iMFI) was introduced as a metric to represent the total functional CMI
      response as a CoP. iMFI is computed by multiplying the relative frequency
      (percent positive) of cells expressing a particular cytokine with the MFI of that
      population, and correlates better with protection in challenge models than either
      the percentage or the MFI of the cytokine-positive population. While
      determination of the iMFI as a CoP can readily be accomplished in animal models
      that allow challenge/protection experiments, this is not feasible in humans for
      ethical reasons. As a first step toward extending the iMFI concept to humans, we 
      investigated the correlation of the iMFI derived from a human innate immune
      response ICS assay with functional cytokine release into the culture supernatant,
      as innate cytokines need to be released to have a functional impact. Next, we
      developed a quantitatively more correlative mathematical approach for calculating
      the functional response of cytokine-producing cells by incorporating the
      assignment of different weights to the magnitude (frequency of cytokine-positive 
      cells) and the quality (the MFI) of the observed innate immune response. We refer
      to this model as generalized iMFI.
FAU - Shooshtari, Parisa
AU  - Shooshtari P
AD  - Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada.
FAU - Fortuno, Edgardo S 3rd
AU  - Fortuno ES 3rd
FAU - Blimkie, Darren
AU  - Blimkie D
FAU - Yu, Miao
AU  - Yu M
FAU - Gupta, Arvind
AU  - Gupta A
FAU - Kollmann, Tobias R
AU  - Kollmann TR
FAU - Brinkman, Ryan R
AU  - Brinkman RR
LA  - eng
GR  - R01 EB008400-01/EB/NIBIB NIH HHS/United States
GR  - N01 AI50023/AI/NIAID NIH HHS/United States
GR  - R01 EB000840/EB/NIBIB NIH HHS/United States
GR  - 1R01EB00840/EB/NIBIB NIH HHS/United States
GR  - R01 EB008400/EB/NIBIB NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cytometry A
JT  - Cytometry. Part A : the journal of the International Society for Analytical
      Cytology
JID - 101235694
RN  - 0 (Cytokines)
RN  - 0 (Toll-Like Receptors)
SB  - IM
MH  - Adult
MH  - Antigen-Presenting Cells/immunology
MH  - Cytokines/*analysis/metabolism
MH  - Female
MH  - Flow Cytometry/*methods
MH  - *Fluorescence
MH  - Humans
MH  - *Immunity, Innate
MH  - Male
MH  - Models, Immunological
MH  - Staining and Labeling/*methods
MH  - Statistics as Topic
MH  - Toll-Like Receptors/agonists
PMC - PMC2930075
MID - NIHMS222171
EDAT- 2010/07/16 06:00
MHDA- 2010/12/31 06:00
CRDT- 2010/07/15 06:00
PHST- 2010/07/15 06:00 [entrez]
PHST- 2010/07/16 06:00 [pubmed]
PHST- 2010/12/31 06:00 [medline]
AID - 10.1002/cyto.a.20943 [doi]
PST - ppublish
SO  - Cytometry A. 2010 Sep;77(9):873-80. doi: 10.1002/cyto.a.20943.


PMID- 20628491
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20220309
IS  - 1654-9880 (Electronic)
IS  - 1654-9880 (Linking)
VI  - 3
DP  - 2010 Jul 9
TI  - Defining features of the practice of global health research: an examination of 14
      global health research teams.
LID - 10.3402/gha.v3i0.5188 [doi]
AB  - OBJECTIVES: This paper strives to develop a pragmatic view of the scope of
      practice and core characteristics of global health research (GHR) by examining
      the activities of 14 Canadian-funded global health teams that were in the process
      of implementing research programs. METHODS: Information was collected by a
      reflective exploration of team proposals and progress reports, a content analysis
      of the outputs from an all-team meeting and review of the literature. RESULTS:
      Teams adopted equity-centered, problem-focused, systems-based approaches intended
      to find upstream determinants that could make people more resilient to social and
      ecological factors impacting their health. Long-term visions and time frames were
      needed to develop and solidify fully functional interdisciplinary, multinational,
      multicultural partnerships. The implementation of research into practice was a
      motivating factor for all teams, but to do this, they recognized the need for
      evidence-based advice on how to best do this. Traditional measures of biomedical 
      research excellence were necessary but not sufficient to encompass views of
      excellence of team-based interdisciplinary research, which includes features like
      originality, coherence and cumulative contributions to fields of study,
      acceptance by peers and success in translating research into gains in health
      status. An innovative and nuanced approached to GHR ethics was needed to deal
      with some unique ethical issues because the needs for GHR were not adequately
      addressed by institutional biomedical research ethics boards. Core competencies
      for GHR researchers were a blend of those needed for health promotion, population
      health, international development, sustainable development, and systems science. 
      DISCUSSION: Developing acceptable and meaningful ways to evaluate the short-term 
      contributions for GHR and forecast its long-term impacts is a strategic priority 
      needed to defend decisions being made in GHR development. Planning and investing 
      to support the underlying GHR elements and competencies that allow for adaptive, 
      innovative, and supportive research partnerships to achieve 'health for all' are 
      more likely to have long-term impacts than building research strategies around
      specific diseases of interest.
FAU - Stephen, Craig
AU  - Stephen C
AD  - Department of Ecosystem and Public Health, Faculty of Veterinary Medicine,
      University of Calgary, Calgary, Alberta, Canada.
FAU - Daibes, Ibrahim
AU  - Daibes I
LA  - eng
PT  - Journal Article
DEP - 20100709
PL  - United States
TA  - Glob Health Action
JT  - Global health action
JID - 101496665
PMC - PMC2903310
OTO - NOTNLM
OT  - competencies
OT  - excellence
OT  - features
OT  - global health
OT  - practice
EDAT- 2010/07/16 06:00
MHDA- 2010/07/16 06:01
CRDT- 2010/07/15 06:00
PHST- 2010/04/04 00:00 [received]
PHST- 2010/06/12 00:00 [revised]
PHST- 2010/06/12 00:00 [accepted]
PHST- 2010/07/15 06:00 [entrez]
PHST- 2010/07/16 06:00 [pubmed]
PHST- 2010/07/16 06:01 [medline]
AID - 10.3402/gha.v3i0.5188 [doi]
PST - epublish
SO  - Glob Health Action. 2010 Jul 9;3. doi: 10.3402/gha.v3i0.5188.


PMID- 20628082
OWN - NLM
STAT- MEDLINE
DCOM- 20120509
LR  - 20220330
IS  - 1470-2738 (Electronic)
IS  - 0143-005X (Linking)
VI  - 65
IP  - 3
DP  - 2011 Mar
TI  - Reporting results of human biomonitoring of environmental chemicals to study
      participants: a comparison of approaches followed in two Canadian studies.
PG  - 191-8
LID - 10.1136/jech.2008.085597 [doi]
AB  - Biomonitoring is used increasingly as an indicator and quantitative measure of
      exposure; however, there is a large gap in interpreting and communicating
      biomonitoring results to study participants. Two separate, national biomonitoring
      initiatives are under way in Canada; the household recruitment-based Canadian
      Health Measures Survey (CHMS) and the clinic recruitment-based Maternal-Infant
      Research on Environmental Chemicals (MIREC) Study. The CHMS provides participants
      with the option to receive all their results, but this option is not provided to 
      MIREC participants. The approach to reporting results to participants depends on 
      the availability of reference ranges and guidelines for which tissue
      concentrations may be interpreted as being elevated or associated with increased 
      health risks, how participants are recruited, unique vulnerabilities of the
      population, legislation governing access to personal information, and decisions
      of research ethics committees. It is the researchers' responsibility to present
      the best case for their approach and, once the decision has been made, to inform 
      participants about access to their results through the consent process.
FAU - Haines, Douglas A
AU  - Haines DA
AD  - Environmental and Radiation Health Sciences Directorate, Health Canada, Ottawa,
      Ontario K1A 0K9, Canada. doug.haines@hc-sc.gc.ca
FAU - Arbuckle, Tye E
AU  - Arbuckle TE
FAU - Lye, Ellen
AU  - Lye E
FAU - Legrand, Melissa
AU  - Legrand M
FAU - Fisher, Mandy
AU  - Fisher M
FAU - Langlois, Renee
AU  - Langlois R
FAU - Fraser, William
AU  - Fraser W
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100713
PL  - England
TA  - J Epidemiol Community Health
JT  - Journal of epidemiology and community health
JID - 7909766
RN  - 0 (Biomarkers)
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Beneficence
MH  - Biomarkers/blood/urine
MH  - Canada
MH  - Child
MH  - Data Collection/methods
MH  - Disclosure
MH  - Environmental Exposure/*analysis
MH  - Environmental Monitoring/*ethics/methods
MH  - Environmental Pollutants/analysis
MH  - Female
MH  - Government Programs
MH  - Health Surveys
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Interviews as Topic
MH  - Life Style
MH  - Male
MH  - Middle Aged
MH  - Personal Autonomy
MH  - Population Surveillance/methods
MH  - Professional-Patient Relations/ethics
MH  - Reference Values
MH  - *Research Subjects/psychology
MH  - Risk Assessment/ethics/methods
MH  - Socioeconomic Factors
MH  - Young Adult
EDAT- 2010/07/16 06:00
MHDA- 2012/05/10 06:00
CRDT- 2010/07/15 06:00
PHST- 2010/07/15 06:00 [entrez]
PHST- 2010/07/16 06:00 [pubmed]
PHST- 2012/05/10 06:00 [medline]
AID - jech.2008.085597 [pii]
AID - 10.1136/jech.2008.085597 [doi]
PST - ppublish
SO  - J Epidemiol Community Health. 2011 Mar;65(3):191-8. doi:
      10.1136/jech.2008.085597. Epub 2010 Jul 13.


PMID- 20627988
OWN - NLM
STAT- MEDLINE
DCOM- 20100719
LR  - 20181023
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 341
DP  - 2010 Jul 13
TI  - US presidential ethics commission grapples with synthetic biology.
PG  - c3732
LID - 10.1136/bmj.c3732 [doi]
LID - bmj.c3732 [pii]
FAU - Roehr, Bob
AU  - Roehr B
LA  - eng
PT  - News
DEP - 20100713
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
SB  - IM
MH  - *Bioethical Issues
MH  - Genes, Synthetic/*ethics
MH  - Genes, Transgenic, Suicide/ethics
MH  - Genetic Engineering/*ethics/trends
MH  - United States
EDAT- 2010/07/16 06:00
MHDA- 2010/07/20 06:00
CRDT- 2010/07/15 06:00
PHST- 2010/07/15 06:00 [entrez]
PHST- 2010/07/16 06:00 [pubmed]
PHST- 2010/07/20 06:00 [medline]
AID - 10.1136/bmj.c3732 [doi]
PST - epublish
SO  - BMJ. 2010 Jul 13;341:c3732. doi: 10.1136/bmj.c3732.


PMID- 20627858
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20211020
IS  - 1438-8871 (Electronic)
IS  - 1438-8871 (Linking)
VI  - 12
IP  - 3
DP  - 2010 Jul 13
TI  - Get your paws off of my pixels: personal identity and avatars as self.
PG  - e28
LID - 10.2196/jmir.1299 [doi]
AB  - There is an astounding silence in the peer-reviewed literature regarding what
      rights a person ought to expect to retain when being represented by an avatar
      rather than a biological body. Before one can have meaningful ethical discussions
      about informed consent in virtual worlds, avatar bodily integrity, and so on, the
      status of avatars vis-a-vis the self must first be decided. We argue that as
      another manifestation of the individual, an individual's avatar should have
      rights analogous to those of a biological body. Our strategy will be to show that
      (1) possessing a physical body is not a necessary condition for possessing
      rights; (2) rights are already extended to representations of a person to which
      no biological consciousness is attached; and (3) when imbued with intentionality,
      some prostheses become "self." We will then argue that avatars meet all of the
      conditions necessary to be protected by rights similar to those enjoyed by a
      biological body. The structure of our argument will take the form of a
      conditional. We will argue that if a user considers an avatar an extension of the
      self, then the avatar has rights analogous to the rights of the user. Finally, we
      will discuss and resolve some of the objections to our position including
      conflicts that may arise when more than one individual considers an avatar to be 
      part of the self.
FAU - Graber, Mark Alan
AU  - Graber MA
AD  - University of Iowa, Carver College of Medicine, Department of Emergency Medicine,
      Iowa City, USA. mark-graber@uiowa.edu
FAU - Graber, Abraham David
AU  - Graber AD
LA  - eng
PT  - Journal Article
DEP - 20100713
PL  - Canada
TA  - J Med Internet Res
JT  - Journal of medical Internet research
JID - 100959882
SB  - IM
MH  - Child
MH  - Child Abuse/legislation & jurisprudence/prevention & control
MH  - Conflict, Psychological
MH  - Emotions
MH  - *Human Rights/legislation & jurisprudence
MH  - Humans
MH  - Interpersonal Relations
MH  - *Personal Autonomy
MH  - *Privacy
MH  - *Self Concept
MH  - *Social Identification
MH  - Technology/trends
PMC - PMC2956325
EDAT- 2010/07/16 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/07/15 06:00
PHST- 2009/07/07 00:00 [received]
PHST- 2009/11/30 00:00 [accepted]
PHST- 2009/10/11 00:00 [revised]
PHST- 2010/07/15 06:00 [entrez]
PHST- 2010/07/16 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - v12i3e28 [pii]
AID - 10.2196/jmir.1299 [doi]
PST - epublish
SO  - J Med Internet Res. 2010 Jul 13;12(3):e28. doi: 10.2196/jmir.1299.


PMID- 20627813
OWN - NLM
STAT- MEDLINE
DCOM- 20110630
LR  - 20220310
IS  - 1873-4898 (Electronic)
IS  - 1477-5131 (Linking)
VI  - 7
IP  - 2
DP  - 2011 Apr
TI  - The microvessel density of the hypospadiac prepuce in children.
PG  - 162-5
LID - 10.1016/j.jpurol.2010.04.017 [doi]
AB  - OBJECTIVE: The blood supply of the hypospadiac prepuce is crucial for success in 
      surgery. Although the vascular anatomy of the hypospadiac prepuce has been
      previously documented, data on microvessel density are missing. It was aimed to
      document the microvessel density of the normal and hypospadiac prepuce. METHODS: 
      After ethical approval of the study, prepuces from 24 children with hypospadias
      undergoing surgical repair and from 9 healthy age-matched controls were stained
      by immunohistochemical methods using panendothelial cell antigen CD31 in order to
      assay their microvessel density. RESULTS: The microvessel density was
      significantly decreased in hypospadiac children when compared to controls
      (P<0.05). A gradual decrease in microvessel density was observed as the severity 
      of the condition increased, indicating a significant negative correlation
      (r=-0.585; P<0.05). CONCLUSION: Our findings should be taken into account when
      considering preoperative treatments such as topical testosterone application or
      operative strategies for hypospadias using prepucial flaps, and also during the
      postoperative course, especially when it is complicated. Further studies are
      needed to clarify the role of vascularity in the pathogenesis of hypospadias and 
      its consequences for surgical repair.
CI  - Copyright (c) 2010 Journal of Pediatric Urology Company. Published by Elsevier
      Ltd. All rights reserved.
FAU - Cagri Savas, Mustafa
AU  - Cagri Savas M
AD  - Suleyman Demirel University Medical School, Department of Pediatric Surgery,
      Isparta, Turkey. cagrisavas@yahoo.com
FAU - Kapucuoglu, Nilgun
AU  - Kapucuoglu N
FAU - Gursoy, Kevser
AU  - Gursoy K
FAU - Baspinar, Sirin
AU  - Baspinar S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100602
PL  - England
TA  - J Pediatr Urol
JT  - Journal of pediatric urology
JID - 101233150
RN  - 0 (Platelet Endothelial Cell Adhesion Molecule-1)
SB  - IM
CIN - J Urol. 2012 Jan;187(1):280. PMID: 22153473
MH  - Biopsy
MH  - Child
MH  - Child, Preschool
MH  - Endothelium, Vascular/metabolism/pathology
MH  - Foreskin/*blood supply/*pathology
MH  - Humans
MH  - Hypospadias/*pathology/surgery
MH  - Infant
MH  - Male
MH  - Microvessels/metabolism/*pathology
MH  - Platelet Endothelial Cell Adhesion Molecule-1/metabolism
EDAT- 2010/07/16 06:00
MHDA- 2011/07/01 06:00
CRDT- 2010/07/15 06:00
PHST- 2010/01/01 00:00 [received]
PHST- 2010/04/25 00:00 [accepted]
PHST- 2010/07/15 06:00 [entrez]
PHST- 2010/07/16 06:00 [pubmed]
PHST- 2011/07/01 06:00 [medline]
AID - S1477-5131(10)00353-0 [pii]
AID - 10.1016/j.jpurol.2010.04.017 [doi]
PST - ppublish
SO  - J Pediatr Urol. 2011 Apr;7(2):162-5. doi: 10.1016/j.jpurol.2010.04.017. Epub 2010
      Jun 2.


PMID- 20627772
OWN - NLM
STAT- MEDLINE
DCOM- 20110203
LR  - 20100716
IS  - 1878-4321 (Electronic)
IS  - 1049-3867 (Linking)
VI  - 20
IP  - 4
DP  - 2010 Jul-Aug
TI  - The Suleman octuplet case: an analysis of multiple ethical issues.
PG  - 260-5
LID - 10.1016/j.whi.2010.04.001 [doi]
AB  - The Suleman octuplet case is the first reported case in which surviving octuplets
      were born as a result of in vitro fertilization and embryo transfer. In this
      case, the octuplets were born to an American single mother of six children, who
      was on public assistance, and who used a sperm donor. This has raised multiple
      ethical questions, which include the ethical obligations of the health care
      providers involved, the informed consent process, as well as moral obligations of
      the mother to her existing children and unborn children. This case analysis
      provides a clinical ethics and prenatal ethics framework, based on relevant
      American media and public documents available from January 26, 2009, to January
      26, 2010, the period of time in which media scrutiny of this case was most
      relevant. Although this analysis introduces broader ethical implications, it is
      not intended as a philosophical discourse regarding the rights of patients to
      reproduce or the rights of society to place limits on who can and who cannot
      reproduce; neither is it intended as an in-depth policy review of reproductive
      technologies. Rather, this analysis focuses on clinical ethics breaches in this
      particular case, which led to an unintended outcome. The relevant clinical
      ethical principles, duties, and obligations are identified, with recommendations 
      for a preventative ethics approach in the absence of clear policies that regulate
      embryo transfer.
FAU - Rosenthal, M Sara
AU  - Rosenthal MS
AD  - Program for Bioethics, Department, Internal Medicine, University of Kentucky,
      Lexington, Kentucky 40536-0284, USA. msrose2@email.uky.edu
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Womens Health Issues
JT  - Women's health issues : official publication of the Jacobs Institute of Women's
      Health
JID - 9101000
SB  - IM
MH  - Child
MH  - Embryo Transfer/*ethics
MH  - *Ethics, Medical
MH  - Female
MH  - Fertilization in Vitro/*ethics/methods
MH  - Health Personnel/*ethics
MH  - Humans
MH  - *Informed Consent
MH  - *Moral Obligations
MH  - *Multiple Birth Offspring
MH  - Pregnancy
MH  - Public Assistance
MH  - United States
EDAT- 2010/07/16 06:00
MHDA- 2011/02/04 06:00
CRDT- 2010/07/15 06:00
PHST- 2009/10/14 00:00 [received]
PHST- 2010/04/06 00:00 [revised]
PHST- 2010/04/06 00:00 [accepted]
PHST- 2010/07/15 06:00 [entrez]
PHST- 2010/07/16 06:00 [pubmed]
PHST- 2011/02/04 06:00 [medline]
AID - S1049-3867(10)00043-5 [pii]
AID - 10.1016/j.whi.2010.04.001 [doi]
PST - ppublish
SO  - Womens Health Issues. 2010 Jul-Aug;20(4):260-5. doi: 10.1016/j.whi.2010.04.001.


PMID- 20627498
OWN - NLM
STAT- MEDLINE
DCOM- 20110921
LR  - 20110613
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 72
IP  - 11
DP  - 2011 Jun
TI  - Genetic testing, governance, and the family in the People's Republic of China.
PG  - 1802-9
LID - 10.1016/j.socscimed.2010.03.052 [doi]
AB  - In western countries the rise of genetic testing has been accompanied by ethical 
      arrangements like autonomy and informed consent that help to dissociate genetics 
      from eugenic policies. However, critics have argued that this trend to increase
      individual choice should be considered as a neoliberal governance strategy to
      promote bio-citizenship. These western concepts are often used to discuss genetic
      testing in the People's Republic of China as well. China's population policy has 
      a reputation for condoning eugenic practices and for ruthless one-child and
      family planning policies, but there have been many reforms recently, which,
      together with the revival and development of traditional religions and beliefs,
      have complicated the discussion about the meaning of the Chinese family. In this 
      context, the introduction of genetic testing in China has been linked to state
      eugenics as well as post-reform neo-liberalist governance. Based on fieldwork and
      various archival and literature studies it explores genetic testing in five
      different Chinese contexts. The analysis makes clear that, although population
      planning in China proceeds from the idea that the planning of family health leads
      to a healthier population, traditional beliefs, individual initiative, group
      pressure, commercial organisations and state policies make for an amalgam of
      genetic testing practices that cannot be understood in terms of eugenics or
      liberal governance.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Sleeboom-Faulkner, Margaret Elizabeth
AU  - Sleeboom-Faulkner ME
AD  - University of Sussex, Department of Anthropology, Brighton, Sussex, United
      Kingdom. m.sleeboom-faulkner@sussex.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20100512
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - China
MH  - Eugenics
MH  - *Family Characteristics
MH  - *Family Planning Policy
MH  - Female
MH  - *Genetic Testing
MH  - Humans
MH  - Male
MH  - Minority Groups
MH  - Muscular Dystrophy, Duchenne/genetics
MH  - *Population Control
MH  - Premarital Examinations
MH  - Private Sector
MH  - Thalassemia/genetics
EDAT- 2010/07/16 06:00
MHDA- 2011/09/22 06:00
CRDT- 2010/07/15 06:00
PHST- 2009/02/18 00:00 [received]
PHST- 2010/03/28 00:00 [revised]
PHST- 2010/03/29 00:00 [accepted]
PHST- 2010/07/15 06:00 [entrez]
PHST- 2010/07/16 06:00 [pubmed]
PHST- 2011/09/22 06:00 [medline]
AID - S0277-9536(10)00339-4 [pii]
AID - 10.1016/j.socscimed.2010.03.052 [doi]
PST - ppublish
SO  - Soc Sci Med. 2011 Jun;72(11):1802-9. doi: 10.1016/j.socscimed.2010.03.052. Epub
      2010 May 12.


PMID- 20627188
OWN - NLM
STAT- MEDLINE
DCOM- 20101101
LR  - 20181201
IS  - 1538-9375 (Electronic)
IS  - 1525-8610 (Linking)
VI  - 11
IP  - 6
DP  - 2010 Jul
TI  - Pause before a PEG: A feeding tube may not be necessary in every candidate!
PG  - 453-6
LID - 10.1016/j.jamda.2009.11.016 [doi]
AB  - Percutaneous endoscopic gastrostomies (PEGs) are a means to provide nutrition in 
      older adults incapable of normal adequate nutrient intake. Often decisions to
      insert a PEG in patients with illness and dementia are made hastily, before
      exhausting every means of feeding and full evaluation for the potential to regain
      capacity to feed normally. Further, ethical aspects often cloud such decisions,
      with data not supporting meaningful long-term improvement in outcomes or quality 
      of life for the recipient of a PEG. Our case illustrates the story of a nursing
      home resident in whom an organized approach determined a reversible basis for his
      inability to feed and the potential to avoid tube insertion.
CI  - 2010 American Medical Directors Association. Published by Elsevier Inc. All
      rights reserved.
FAU - Aparanji, Krishna P
AU  - Aparanji KP
AD  - Montefiore Medical Center, Bronx, NY 10466, USA.
FAU - Dharmarajan, T S
AU  - Dharmarajan TS
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Am Med Dir Assoc
JT  - Journal of the American Medical Directors Association
JID - 100893243
SB  - IM
MH  - Aged
MH  - Deglutition Disorders
MH  - Endoscopy, Gastrointestinal
MH  - Enteral Nutrition/*statistics & numerical data
MH  - Humans
MH  - Male
MH  - *Quality of Health Care
MH  - Quality of Life
MH  - Radiography, Thoracic
EDAT- 2010/07/16 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/07/15 06:00
PHST- 2009/11/23 00:00 [received]
PHST- 2009/11/29 00:00 [revised]
PHST- 2009/11/30 00:00 [accepted]
PHST- 2010/07/15 06:00 [entrez]
PHST- 2010/07/16 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - S1525-8610(09)00419-8 [pii]
AID - 10.1016/j.jamda.2009.11.016 [doi]
PST - ppublish
SO  - J Am Med Dir Assoc. 2010 Jul;11(6):453-6. doi: 10.1016/j.jamda.2009.11.016.


PMID- 20626953
OWN - NLM
STAT- MEDLINE
DCOM- 20101019
LR  - 20141120
IS  - 1815-7920 (Electronic)
IS  - 1027-3719 (Linking)
VI  - 14
IP  - 8
DP  - 2010 Aug
TI  - The impact of the method of consent on response rates in the ISAAC time trends
      study.
PG  - 1059-65
AB  - BACKGROUND: Centres in Phases I and III of the International Study of Asthma and 
      Allergies in Childhood (ISAAC) programme used the method of consent (passive or
      active) required by local ethics committees. METHODS: Retrospectively,
      relationships between achieved response rates and method of consent for 13-14 and
      6-7-year-olds (adolescents and children, respectively), were examined between
      phases and between English and non-English language centres. RESULTS: Information
      was obtained for 113 of 115 centres for adolescents and 72/72 centres for
      children. Both age groups: most centres using passive consent achieved high
      response rates (>80% adolescents and >70% children). English language centres
      using active consent showed a larger decrease in response rate. Adolescents:
      seven centres changed from passive consent in Phase I to active consent in Phase 
      III (median decrease of 13%), with five centres showing lower response rates (as 
      low as 34%). Children: no centre changed consent method between phases. Centres
      using active consent had lower median response rates (lowest response rate 45%). 
      CONCLUSION: The requirement for active consent for population school-based
      questionnaire studies can impact negatively on response rates, particularly
      English language centres, thus adversely affecting the validity of the data.
      Ethics committees need to consider this issue carefully.
FAU - Ellwood, P
AU  - Ellwood P
AD  - Department of Paediatrics, Child and Youth Health, The University of Auckland,
      Auckland, New Zealand. p.ellwood@auckland.ac.nz
FAU - Asher, M I
AU  - Asher MI
FAU - Stewart, A W
AU  - Stewart AW
CN  - ISAAC Phase III Study Group
LA  - eng
PT  - Clinical Trial, Phase I
PT  - Clinical Trial, Phase III
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - Int J Tuberc Lung Dis
JT  - The international journal of tuberculosis and lung disease : the official journal
      of the International Union against Tuberculosis and Lung Disease
JID - 9706389
SB  - IM
CIN - Int J Tuberc Lung Dis. 2010 Aug;14(8):938. PMID: 20626935
MH  - Adolescent
MH  - Asthma/epidemiology
MH  - Child
MH  - Consent Forms/*trends
MH  - Cross-Sectional Studies
MH  - Female
MH  - Global Health
MH  - *Health Surveys
MH  - Humans
MH  - Hypersensitivity/*epidemiology
MH  - Male
MH  - Prevalence
MH  - Time Factors
IR  - Ait-Khaled N
FIR - Ait-Khaled, N
IR  - Anderson HR
FIR - Anderson, H R
IR  - Asher MI
FIR - Asher, M I
IR  - Beasley R
FIR - Beasley, R
IR  - Bjorksten B
FIR - Bjorksten, B
IR  - Brunekreef B
FIR - Brunekreef, B
IR  - Crane J
FIR - Crane, J
IR  - Ellwood P
FIR - Ellwood, P
IR  - Flohr C
FIR - Flohr, C
IR  - Foliaki S
FIR - Foliaki, S
IR  - Forastiere F
FIR - Forastiere, F
IR  - Garcia-Marcos L
FIR - Garcia-Marcos, L
IR  - Keil U
FIR - Keil, U
IR  - Lai CK
FIR - Lai, C K W
IR  - Mallol J
FIR - Mallol, J
IR  - Mitchell EA
FIR - Mitchell, E A
IR  - Montefort S
FIR - Montefort, S
IR  - Odhiambo J
FIR - Odhiambo, J
IR  - Pearce N
FIR - Pearce, N
IR  - Robertson CF
FIR - Robertson, C F
IR  - Stewart AW
FIR - Stewart, A W
IR  - Strachan D
FIR - Strachan, D
IR  - von Mutius E
FIR - von Mutius, E
IR  - Weiland SK
FIR - Weiland, S K
IR  - Weinmayr G
FIR - Weinmayr, G
IR  - Williams H
FIR - Williams, H
IR  - Wong G
FIR - Wong, G
IR  - Benhabyles B
FIR - Benhabyles, B
IR  - Esamai FO
FIR - Esamai, F O
IR  - Ng'anga L
FIR - Ng'anga, L
IR  - Bouayad Z
FIR - Bouayad, Z
IR  - Onadeko BO
FIR - Onadeko, B O
IR  - Zar HJ
FIR - Zar, H J
IR  - Jerray M
FIR - Jerray, M
IR  - Chen YZ
FIR - Chen, Y Z
IR  - Zhong NS
FIR - Zhong, N-S
IR  - Lau YL
FIR - Lau, Y L
IR  - Wong G
FIR - Wong, G
IR  - Kartasasmita CB
FIR - Kartasasmita, C B
IR  - Odajima H
FIR - Odajima, H
IR  - Teh KH
FIR - Teh, K H
IR  - de Bruyne J
FIR - de Bruyne, J
IR  - Quah BS
FIR - Quah, B S
IR  - Cua-Lim F
FIR - Cua-Lim, F
IR  - Goh DY
FIR - Goh, D Y T
IR  - Lee HB
FIR - Lee, H-B
IR  - Huang JL
FIR - Huang, J-L
IR  - Vichyanond P
FIR - Vichyanond, P
IR  - Trakultivakom M
FIR - Trakultivakom, M
IR  - Masjedi MR
FIR - Masjedi, M-R
IR  - al-Momen JA
FIR - al-Momen, J A
IR  - Montefort S
FIR - Montefort, S
IR  - Mahmood N
FIR - Mahmood, N
IR  - Al-Rawas O
FIR - Al-Rawas, O
IR  - Khatav VA
FIR - Khatav, V A
IR  - Kumar L
FIR - Kumar, L
IR  - Setty G
FIR - Setty, G
IR  - Jain KC
FIR - Jain, K C
IR  - Sukumaran TU
FIR - Sukumaran, T U
IR  - Joshi MK
FIR - Joshi, M K
IR  - Pherwani AV
FIR - Pherwani, A V
IR  - Sharma SK
FIR - Sharma, S K
IR  - Hanumante NM
FIR - Hanumante, N M
IR  - Guimaraes IM
FIR - Guimaraes, I M E
IR  - Baena-Cagnani CE
FIR - Baena-Cagnani, C E
IR  - Rosario N
FIR - Rosario, N
IR  - Fischer GB
FIR - Fischer, G B
IR  - de Britto M
FIR - de Britto, M
IR  - de Freitas Souza L
FIR - de Freitas Souza, L
IR  - Sole D
FIR - Sole, D
IR  - Amarales L
FIR - Amarales, L
IR  - Aguilar P
FIR - Aguilar, P
IR  - Calvo MA
FIR - Calvo, M A
IR  - Soto-Quiros ME
FIR - Soto-Quiros, M E
IR  - Romieu I
FIR - Romieu, I
IR  - Cukier G
FIR - Cukier, G
IR  - Guggiari-Chase JA
FIR - Guggiari-Chase, J A
IR  - Chiarella P
FIR - Chiarella, P
IR  - Holgado D
FIR - Holgado, D
IR  - Howitt ME
FIR - Howitt, M E
IR  - Sears M
FIR - Sears, M
IR  - Rennie D
FIR - Rennie, D
IR  - Yeatts K
FIR - Yeatts, K
IR  - Redding GJ
FIR - Redding, G J
IR  - Priftanji A
FIR - Priftanji, A
IR  - Riikjarv MA
FIR - Riikjarv, M-A
IR  - Pekkanen J
FIR - Pekkanen, J
IR  - Gotua M
FIR - Gotua, M
IR  - Svabe V
FIR - Svabe, V
IR  - Kudzyte J
FIR - Kudzyte, J
IR  - Lis G
FIR - Lis, G
IR  - Breborowicz A
FIR - Breborowicz, A
IR  - Deleanu D
FIR - Deleanu, D
IR  - Kondiourina EG
FIR - Kondiourina, E G
IR  - Vogt H
FIR - Vogt, H
IR  - Ognev V
FIR - Ognev, V
IR  - Robertson CF
FIR - Robertson, C F
IR  - Marks G
FIR - Marks, G
IR  - Asher MI
FIR - Asher, M I
IR  - Moyes C
FIR - Moyes, C
IR  - Pattemore P
FIR - Pattemore, P
IR  - Mackay R
FIR - Mackay, R
IR  - Pearce N
FIR - Pearce, N
IR  - Haidinger G
FIR - Haidinger, G
IR  - Weyler J
FIR - Weyler, J
IR  - Standring P
FIR - Standring, P
IR  - Goulding R
FIR - Goulding, R
IR  - Keil U
FIR - Keil, U
IR  - Steriu A
FIR - Steriu, A
IR  - Bonci E
FIR - Bonci, E
IR  - Galassi C
FIR - Galassi, C
IR  - Petronio MG
FIR - Petronio, M G
IR  - Chellini E
FIR - Chellini, E
IR  - Bisanti L
FIR - Bisanti, L
IR  - Forastiere F
FIR - Forastiere, F
IR  - Sestini P
FIR - Sestini, P
IR  - Ciccone G
FIR - Ciccone, G
IR  - Piffer S
FIR - Piffer, S
IR  - Camara R
FIR - Camara, R
IR  - Rosado Pinto JE
FIR - Rosado Pinto, J E
IR  - Nunes C
FIR - Nunes, C
IR  - dos Santos JM
FIR - dos Santos, J M Lopes
IR  - Busquets RM
FIR - Busquets, R M
IR  - Gonzalez Diaz C
FIR - Gonzalez Diaz, C
IR  - Garcia-Marcos L
FIR - Garcia-Marcos, L
IR  - Arnedo-Pena A
FIR - Arnedo-Pena, A
IR  - Garcia Hernandez G
FIR - Garcia Hernandez, G
IR  - Guillen-Grima F
FIR - Guillen-Grima, F
IR  - Morales-Suarez-Varela MM
FIR - Morales-Suarez-Varela, M M
IR  - Blanco Quiros A
FIR - Blanco Quiros, A
IR  - Anderson HR
FIR - Anderson, H R
IR  - Austin JB
FIR - Austin, J B
IR  - Shamssain MH
FIR - Shamssain, M H
IR  - Strachan D
FIR - Strachan, D
IR  - Burr M
FIR - Burr, M
IR  - Anderson HR
FIR - Anderson, H R
IR  - Mallol J
FIR - Mallol, J
IR  - Lai C
FIR - Lai, C
IR  - Anderson HR
FIR - Anderson, H R
IR  - Shah J
FIR - Shah, J
IR  - Baratawidjaja K
FIR - Baratawidjaja, K
IR  - Nishima S
FIR - Nishima, S
IR  - Baeza-Bacab M
FIR - Baeza-Bacab, M
IR  - Manning P
FIR - Manning, P
IR  - Khaitov RM
FIR - Khaitov, R M
IR  - Lee B
FIR - Lee, B
IR  - Nilsson L
FIR - Nilsson, L
EDAT- 2010/07/16 06:00
MHDA- 2010/10/20 06:00
CRDT- 2010/07/15 06:00
PHST- 2010/07/15 06:00 [entrez]
PHST- 2010/07/16 06:00 [pubmed]
PHST- 2010/10/20 06:00 [medline]
PST - ppublish
SO  - Int J Tuberc Lung Dis. 2010 Aug;14(8):1059-65.


PMID- 20626907
OWN - NLM
STAT- MEDLINE
DCOM- 20100924
LR  - 20220411
IS  - 1471-2334 (Electronic)
IS  - 1471-2334 (Linking)
VI  - 10
DP  - 2010 Jul 13
TI  - Ribavirin for Crimean-Congo hemorrhagic fever: systematic review and
      meta-analysis.
PG  - 207
LID - 10.1186/1471-2334-10-207 [doi]
AB  - BACKGROUND: Crimean-Congo hemorrhagic fever epidemics often occur in areas where 
      health services are limited, and result in high case fatality rates. Besides
      intensive care, ribavirin is often recommended. A solid evidence base for the use
      of this drug will help justify assuring access to the drug in areas where
      epidemics are common. METHODS: We carried out a systematic review of
      observational and experimental studies of people with suspected or confirmed
      Crimean-Congo hemorrhagic fever that included comparisons between patients given 
      ribavirin and those not. We extracted data on mortality, hospital stay, and
      adverse events. Risk of bias was assessed using a standard checklist, and data
      were presented in meta-analytical graphs, stratified by study design, and GRADE
      tables presented. The risk of bias was summarised using the GRADE method.
      RESULTS: 21 unique studies, including one randomised controlled trial of
      ribavirin, were included. Quality of the evidence was very low, with a Down and
      Black median score of 4 (maximum possible 33). Ribavirin treatment was not shown 
      to be superior to no ribavirin treatment for mortality rate in a single RCT (RR: 
      1.13, 95%CI: 0.29 to 4.32, 136 participants, GRADE=low quality evidence); but
      ribavirin was associated with reduced mortality by 44% when compared to no
      ribavirin treatment in the pooled observational studies (RR: 0.56, 95%CI: 0.35 to
      0.90, 955 participants; GRADE=very low quality evidence). Adverse events were
      more common with the ribavirin patients, but no severe adverse events were
      reported. No difference in length of hospital stay was reported. CONCLUSIONS: No 
      clear message of benefit is available from the current data on ribavirin as
      observational data are heavily confounded, and the one trial carried out has
      limited power. However, ribavirin could potentially have benefits in this
      condition and these results clearly indicate a pragmatic, randomised controlled
      trial in the context of good quality supportive care, is urgently needed and
      ethically justified.
FAU - Soares-Weiser, Karla
AU  - Soares-Weiser K
AD  - Enhance Reviews Ltd, 5 Percy Street, Office 4, London, W1T 1DG, UK.
      karla@enhance-reviews.com
FAU - Thomas, Sherine
AU  - Thomas S
FAU - Thomson, Gail
AU  - Thomson G
FAU - Garner, Paul
AU  - Garner P
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20100713
PL  - England
TA  - BMC Infect Dis
JT  - BMC infectious diseases
JID - 100968551
RN  - 0 (Antiviral Agents)
RN  - 49717AWG6K (Ribavirin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antiviral Agents/adverse effects/*therapeutic use
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Hemorrhagic Fever, Crimean/*drug therapy/mortality
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Length of Stay
MH  - Male
MH  - Middle Aged
MH  - Randomized Controlled Trials as Topic
MH  - Ribavirin/adverse effects/*therapeutic use
MH  - Treatment Outcome
MH  - Young Adult
RF  - 55
PMC - PMC2912908
EDAT- 2010/07/16 06:00
MHDA- 2010/09/25 06:00
CRDT- 2010/07/15 06:00
PHST- 2010/05/06 00:00 [received]
PHST- 2010/07/13 00:00 [accepted]
PHST- 2010/07/15 06:00 [entrez]
PHST- 2010/07/16 06:00 [pubmed]
PHST- 2010/09/25 06:00 [medline]
AID - 1471-2334-10-207 [pii]
AID - 10.1186/1471-2334-10-207 [doi]
PST - epublish
SO  - BMC Infect Dis. 2010 Jul 13;10:207. doi: 10.1186/1471-2334-10-207.


PMID- 20626898
OWN - NLM
STAT- MEDLINE
DCOM- 20101129
LR  - 20211020
IS  - 1758-3284 (Electronic)
IS  - 1758-3284 (Linking)
VI  - 2
DP  - 2010 Jul 13
TI  - Living related hemi-face skin transplant using radial forearm free flap for a
      xeroderma pigmentosa patient: early outcome.
PG  - 18
LID - 10.1186/1758-3284-2-18 [doi]
AB  - INTRODUCTION: Xeroderma pigmentosa (XP) is a hereditary disease characterized by 
      deficient repair of DNA damage that occurred on exposure of the skin to
      ultraviolet irradiation. The affected children have a propensity to develop
      multiple skin cancers mainly in the face and eventually die before the age of 20.
      HYPOTHESIS: Allograft replacement of facial skin by a healthy skin from normal
      person might decrease the incidence of skin cancer development, the number of
      surgical procedures, and eventually might improve the survival of these miserable
      patients. METHODS: As Cadaveric organs are unavailable in our country. After
      approval from the ethical committee, confirmed agreement of the donor and the
      patient's guardian, a radial forearm free flap was transplanted from an ABO
      compatible mother to her 5 year old daughter with XP. The mother had an older
      daughter died from the same disease at the age of 14. The flap replaced skin of
      the hemi face that developed precancerous lesions. The girl was kept on adjusted 
      doses of immunosuppressive drugs. RESULTS: The flap survived, wounds healed
      uneventfully. The flap developed a reddish spot one and half month following
      transplant where baseline skin biopsy was taken. In the fifth months the girl
      presented with bad non salvageable rejection that ended up loosing the flap. On
      long term follow up, the girl started to develop skin lesion on the virgin half
      of the face. Our early cosmetic result replacing half of the facial skin was very
      promising. In addition the girl did not develop skin lesions in the operated
      site. CONCLUSION: Our early cosmetic result was very promising. In addition to
      this, the girl did not develop skin lesions in the operated side of the face.
FAU - Amin, Ayman
AU  - Amin A
AD  - Surgical Oncology Department, National Cancer Instituite, Cairo, Egypt.
      aymanamin@hotmail.com
FAU - Bassiouny, Mahmoud
AU  - Bassiouny M
FAU - Sallam, Kareem
AU  - Sallam K
FAU - Ghally, Galal
AU  - Ghally G
FAU - El-Karaksy, Hanaa
AU  - El-Karaksy H
FAU - El-Haddad, Alaa
AU  - El-Haddad A
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20100713
PL  - England
TA  - Head Neck Oncol
JT  - Head & neck oncology
JID - 101479704
SB  - IM
MH  - Child, Preschool
MH  - Face/surgery
MH  - Facial Transplantation
MH  - Female
MH  - Forearm/surgery
MH  - Humans
MH  - Reconstructive Surgical Procedures/methods
MH  - Skin Transplantation/*methods
MH  - *Surgical Flaps
MH  - Treatment Outcome
MH  - Xeroderma Pigmentosum/*surgery
PMC - PMC2908605
EDAT- 2010/07/16 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/07/15 06:00
PHST- 2010/07/01 00:00 [received]
PHST- 2010/07/13 00:00 [accepted]
PHST- 2010/07/15 06:00 [entrez]
PHST- 2010/07/16 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 1758-3284-2-18 [pii]
AID - 10.1186/1758-3284-2-18 [doi]
PST - epublish
SO  - Head Neck Oncol. 2010 Jul 13;2:18. doi: 10.1186/1758-3284-2-18.


PMID- 20626171
OWN - NLM
STAT- MEDLINE
DCOM- 20101007
LR  - 20100714
IS  - 1009-3591 (Print)
IS  - 1009-3591 (Linking)
VI  - 16
IP  - 4
DP  - 2010 Apr
TI  - [Ethical thinking on sperm use in human assisted reproductive technology].
PG  - 377-80
AB  - The use of sperm, which is indispensable for embryo formation in human assisted
      reproductive technology (ART), has contributed a lot to social harmony, home
      happiness and advancement of related science and technology. However, it also
      yields a series of ethical problems. Proper handling of the contradictory
      relationship of ethical principles with science and technology is conducive to
      the healthy development of human ART.
FAU - Li, Yan
AU  - Li Y
AD  - Department of Social Medicine and Health Service Management, School of Public
      Health, Central South University, Changsha, Hunan 410078, China.
      liyanr0601@126.com
FAU - Xu, Hui-Lan
AU  - Xu HL
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Nan Ke Xue
JT  - Zhonghua nan ke xue = National journal of andrology
JID - 101093592
SB  - IM
MH  - Humans
MH  - Male
MH  - Reproductive Techniques, Assisted/*ethics
MH  - Sperm Banks/*ethics
MH  - *Spermatozoa
EDAT- 2010/07/16 06:00
MHDA- 2010/10/12 06:00
CRDT- 2010/07/15 06:00
PHST- 2010/07/15 06:00 [entrez]
PHST- 2010/07/16 06:00 [pubmed]
PHST- 2010/10/12 06:00 [medline]
PST - ppublish
SO  - Zhonghua Nan Ke Xue. 2010 Apr;16(4):377-80.


PMID- 20625616
OWN - NLM
STAT- MEDLINE
DCOM- 20101108
LR  - 20220311
IS  - 0304-4602 (Print)
IS  - 0304-4602 (Linking)
VI  - 39
IP  - 6
DP  - 2010 Jun
TI  - Knowledge, attitudes and practices of the Advance Medical Directive in a
      residential estate in Singapore.
PG  - 424-8
AB  - INTRODUCTION: This study investigates the knowledge, attitudes and practices of
      residents in a residential estate in Singapore on the Advance Medical Directive
      (AMD). MATERIALS AND METHODS: A community-based cross-sectional study was
      conducted with residents in the residential estate of Toa Payoh Lorong 6,
      Singapore. A stratifi ed random sampling was conducted to obtain a representative
      sample of the estate. Only residents aged 21 years and older were included. An
      interviewer-administered questionnaire was conducted, and only those who
      understood the AMD suffi ciently were further evaluated on their knowledge,
      attitudes and practices. RESULTS: A total of 414 residents were enrolled (50.1%
      response rate). Only 37.9% of the participants knew about the AMD prior to this
      study. Participants who had a higher knowledge level of AMD, did not wish "for an
      artifi cially prolonged life", "to be kept alive indefi nitely on a life-support 
      machine", wished to "lessen the fi nancial burden of loved ones", "avoid
      prolonged suffering" and accepted the "imminence of death" were more willing to
      sign an AMD. However, "religious beliefs", "personal ethical views", "dissuasion 
      by family members" and "unclear terminology in the AMD" discouraged the
      participants from signing an AMD. After adjusting for signifi cant factors,
      participants who did not wish "to be kept alive indefi nitely on a life-support
      machine" and accepted the "imminence of death" were found to correlate signifi
      cantly with the willingness to sign an AMD [Prevalence Rate Ratio (PRR) = 2.050
      [1.140-3.685], P = 0.016; PRR = 2.669 [1.449-4.917], P = 0.02, respectively].
      CONCLUSIONS: There is a need to increase awareness on the AMD. Public education
      methods can be improved to inform residents on the implications of the AMD.
FAU - Tay, Matthew
AU  - Tay M
AD  - Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
FAU - Chia, Sin Eng
AU  - Chia SE
FAU - Sng, Judy
AU  - Sng J
LA  - eng
PT  - Journal Article
PL  - Singapore
TA  - Ann Acad Med Singap
JT  - Annals of the Academy of Medicine, Singapore
JID - 7503289
SB  - IM
MH  - Adult
MH  - *Advance Care Planning
MH  - Aged
MH  - Aged, 80 and over
MH  - Cross-Sectional Studies
MH  - Decision Making
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Singapore
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2010/07/14 06:00
MHDA- 2010/11/09 06:00
CRDT- 2010/07/14 06:00
PHST- 2010/07/14 06:00 [entrez]
PHST- 2010/07/14 06:00 [pubmed]
PHST- 2010/11/09 06:00 [medline]
PST - ppublish
SO  - Ann Acad Med Singap. 2010 Jun;39(6):424-8.


PMID- 20623394
OWN - NLM
STAT- MEDLINE
DCOM- 20101004
LR  - 20100712
IS  - 1096-4665 (Electronic)
IS  - 0739-9332 (Linking)
VI  - 31
IP  - 8
DP  - 2010 Aug
TI  - Religiosity and sexuality: experiences of Brazilian Catholic women.
PG  - 700-17
LID - 10.1080/07399332.2010.486881 [doi]
AB  - The purpose of this study was to describe the experiences of a group of Catholic 
      women related to the orientations received from priests and parents and their
      influence on sexual attitudes. The oral history method was used to interview 17
      Catholic women. Three categories summarize women's experiences: orientations
      about sexuality received from priests; lack of orientation or existence of open
      dialogue about sexuality: distinct experiences in the family context; adherence
      or repudiation; and distinct attitudes toward orientations received. Health
      professionals systematically should seek knowledge about women's religious
      principles, because this is essential for meaningful and ethical health care.
FAU - Hoga, Luiza Akiko Komura
AU  - Hoga LA
AD  - Department of Maternal and Child Nursing, School of Nursing, University of Sao
      Paulo, Sao Paulo 05403-000, Brazil. kikatuca@usp.br
FAU - Tiburcio, Cristiane Alves
AU  - Tiburcio CA
FAU - Borges, Ana Luiza Vilela
AU  - Borges AL
FAU - Reberte, Luciana Magnoni
AU  - Reberte LM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Health Care Women Int
JT  - Health care for women international
JID - 8411543
MH  - Adult
MH  - *Attitude
MH  - Brazil
MH  - *Catholicism
MH  - Delivery of Health Care
MH  - Education
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - *Sexuality
MH  - Young Adult
EDAT- 2010/07/14 06:00
MHDA- 2010/10/05 06:00
CRDT- 2010/07/13 06:00
PHST- 2010/07/13 06:00 [entrez]
PHST- 2010/07/14 06:00 [pubmed]
PHST- 2010/10/05 06:00 [medline]
AID - 924175146 [pii]
AID - 10.1080/07399332.2010.486881 [doi]
PST - ppublish
SO  - Health Care Women Int. 2010 Aug;31(8):700-17. doi: 10.1080/07399332.2010.486881.


PMID- 20622888
OWN - NLM
STAT- MEDLINE
DCOM- 20110211
LR  - 20211020
IS  - 1745-7262 (Electronic)
IS  - 1008-682X (Linking)
VI  - 12
IP  - 6
DP  - 2010 Nov
TI  - To name or not to name? An overview of the social and ethical issues raised by
      removing anonymity from sperm donors.
PG  - 801-6
LID - 10.1038/aja.2010.60 [doi]
AB  - The aim of this paper is to focus on the ethical issues raised by the removal of 
      anonymity from sperm donors. The increasing currency of a 'right to genetic
      truth' is clearly visible in the drive to revise the legislation on donor
      anonymity in Western and European countries. The ethical debate is polarized
      between the 'right to privacy' of the donor or parent and the 'right to know' of 
      the prospective child. However, it is evident that religious, social and cultural
      attitudes have an overarching impact on attitudes towards sperm donation
      generally and anonymity specifically. In Asian countries, the social and cultural
      heritage is hugely diverse and different from those of the West. This review
      considers the research exploring the complexity of ethical issues informing this 
      debate, and argues that parent's decisions to reveal donor insemination origins
      to their children are highly complex and relate to a range of social and cultural
      attitudes that have not been addressed within the policy to remove anonymity from
      sperm donors.
FAU - Burr, Jennifer A
AU  - Burr JA
AD  - University of Sheffield School of Health and Related Research, Sheffield SA1 4DA,
      UK. j.a.burr@sheffield.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20100712
PL  - China
TA  - Asian J Androl
JT  - Asian journal of andrology
JID - 100942132
SB  - IM
MH  - Asia
MH  - Attitude
MH  - Child
MH  - Confidentiality/ethics/legislation & jurisprudence
MH  - Europe
MH  - Female
MH  - Homosexuality, Female/psychology
MH  - Humans
MH  - *Insemination, Artificial, Heterologous/ethics
MH  - Male
MH  - Privacy
MH  - Self Disclosure
MH  - *Spermatozoa
MH  - Tissue Donors/*ethics/*legislation & jurisprudence
MH  - Tissue and Organ Procurement/*ethics
MH  - Truth Disclosure/ethics
PMC - PMC3739075
EDAT- 2010/07/14 06:00
MHDA- 2011/02/12 06:00
CRDT- 2010/07/13 06:00
PHST- 2010/07/13 06:00 [entrez]
PHST- 2010/07/14 06:00 [pubmed]
PHST- 2011/02/12 06:00 [medline]
AID - aja201060 [pii]
AID - 10.1038/aja.2010.60 [doi]
PST - ppublish
SO  - Asian J Androl. 2010 Nov;12(6):801-6. doi: 10.1038/aja.2010.60. Epub 2010 Jul 12.


PMID- 20622781
OWN - NLM
STAT- MEDLINE
DCOM- 20100816
LR  - 20161125
IS  - 0966-0461 (Print)
IS  - 0966-0461 (Linking)
VI  - 19
IP  - 11
DP  - 2010 Jun 10-23
TI  - A partnership approach to learning about accountability.
PG  - 718-9
AB  - Clinicians and healthcare providers are frequently reminded that they are
      'accountable' practitioners - but what is the definition of accountability, and
      how does it apply in a practical and legal context? To clarify these issues, the 
      University of Nottingham School of Nursing has formed a partnership with Browne
      Jacobson Solicitors. Together they have developed a 7-stage training programme
      for nursing students which covers the key aspects of accountability, including
      ethical concepts, the law of negligence, and scenario-based training on being
      called as a witness in an investigation. This article introduces the implications
      of accountability and describes the structure and syllabus of the programme,
      including participants' feedback on the benefits of the experience.
FAU - Plant, Nigel
AU  - Plant N
AD  - University of Nottingham School of Nursing, Midwifery and Physiotherapy.
FAU - Pitt, Richard
AU  - Pitt R
FAU - Troke, Ben
AU  - Troke B
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Nurs
JT  - British journal of nursing (Mark Allen Publishing)
JID - 9212059
MH  - *Cooperative Behavior
MH  - *Social Responsibility
MH  - United Kingdom
EDAT- 2010/07/14 06:00
MHDA- 2010/08/17 06:00
CRDT- 2010/07/13 06:00
PHST- 2010/07/13 06:00 [entrez]
PHST- 2010/07/14 06:00 [pubmed]
PHST- 2010/08/17 06:00 [medline]
AID - 10.12968/bjon.2010.19.11.48408 [doi]
PST - ppublish
SO  - Br J Nurs. 2010 Jun 10-23;19(11):718-9. doi: 10.12968/bjon.2010.19.11.48408.


PMID- 20622399
OWN - NLM
STAT- MEDLINE
DCOM- 20100901
LR  - 20151221
IS  - 0972-2823 (Electronic)
IS  - 0022-3859 (Linking)
VI  - 56
IP  - 2
DP  - 2010 Apr-Jun
TI  - Restricting access to publications from funded research: ethical issues and
      solutions.
PG  - 154-6
LID - 10.4103/0022-3859.65286 [doi]
AB  - India is becoming one of the hubs of clinical research. Commensurate with these
      advances, the government funding for biomedical research in thrust areas is also 
      increasing. The Indian Council of Medical Research (ICMR), Department of
      Biotechnology (DBT), Department of Science and Technology (DST) are some of the
      government organizations which provide financial support for various research
      projects. The results of the funded research projects are published in various
      international journals. Most of these journals have an access to paid subscribers
      only. Hence it is unethical to use the research grants from government (people's 
      money) and not allow the scientific community free access to the results of the
      study. To tackle such issues, these agencies should sign the Berlin declaration
      and create open access repositories. A public access policy should be formulated 
      and listed in JULIET. The funding bodies in India should also join Pubmed Central
      (PMC) to form PMC India so that every investigator who has received grants would 
      submit the full text of the paper published from his study and these can be made 
      freely accessible to everyone. Universities and research institutions should also
      develop institutional open access repositories. The public access policy has
      definitive advantages and should be implemented.
FAU - Manikandan, S
AU  - Manikandan S
AD  - Department of Pharmacology, Mahatma Gandhi Medical College and Research
      Institute, Pondicherry, 607 402, India.
FAU - Vani, N Isai
AU  - Vani NI
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Postgrad Med
JT  - Journal of postgraduate medicine
JID - 2985196R
SB  - IM
MH  - *Access to Information
MH  - Humans
MH  - India
MH  - *Information Dissemination
MH  - Periodicals as Topic
MH  - Public Policy
MH  - Publications
MH  - *Research Support as Topic/economics
EDAT- 2010/07/14 06:00
MHDA- 2010/09/02 06:00
CRDT- 2010/07/13 06:00
PHST- 2010/07/13 06:00 [entrez]
PHST- 2010/07/14 06:00 [pubmed]
PHST- 2010/09/02 06:00 [medline]
AID - jpgm_2010_56_2_154_65286 [pii]
AID - 10.4103/0022-3859.65286 [doi]
PST - ppublish
SO  - J Postgrad Med. 2010 Apr-Jun;56(2):154-6. doi: 10.4103/0022-3859.65286.


PMID- 20622030
OWN - NLM
STAT- MEDLINE
DCOM- 20101203
LR  - 20220316
IS  - 1535-4970 (Electronic)
IS  - 1073-449X (Linking)
VI  - 182
IP  - 10
DP  - 2010 Nov 15
TI  - Viral load drives disease in humans experimentally infected with respiratory
      syncytial virus.
PG  - 1305-14
LID - 10.1164/rccm.201002-0221OC [doi]
AB  - RATIONALE: Respiratory syncytial virus (RSV) is the leading cause of childhood
      lower respiratory infection, yet viable therapies are lacking. Two major
      challenges have stalled antiviral development: ethical difficulties in performing
      pediatric proof-of-concept studies and the prevailing concept that the disease is
      immune-mediated rather than being driven by viral load. OBJECTIVES: The
      development of a human experimental wild-type RSV infection model to address
      these challenges. METHODS: Healthy volunteers (n = 35), in five cohorts, received
      increasing quantities (3.0-5.4 log plaque-forming units/person) of wild-type
      RSV-A intranasally. MEASUREMENTS AND MAIN RESULTS: Overall, 77% of volunteers
      consistently shed virus. Infection rate, viral loads, disease severity, and
      safety were similar between cohorts and were unrelated to quantity of RSV
      received. Symptoms began near the time of initial viral detection, peaked in
      severity near when viral load peaked, and subsided as viral loads (measured by
      real-time polymerase chain reaction) slowly declined. Viral loads correlated
      significantly with intranasal proinflammatory cytokine concentrations (IL-6 and
      IL-8). Increased viral load correlated consistently with increases in multiple
      different disease measurements (symptoms, physical examination, and amount of
      nasal mucus). CONCLUSIONS: Viral load appears to drive disease manifestations in 
      humans with RSV infection. The observed parallel viral and disease kinetics
      support a potential clinical benefit of RSV antivirals. This reproducible model
      facilitates the development of future RSV therapeutics.
FAU - DeVincenzo, John P
AU  - DeVincenzo JP
AD  - Department of Pediatrics, University of Tennessee College of Medicine, Memphis,
      USA. jdevincenzo@uthsc.edu
FAU - Wilkinson, Tom
AU  - Wilkinson T
FAU - Vaishnaw, Akshay
AU  - Vaishnaw A
FAU - Cehelsky, Jeff
AU  - Cehelsky J
FAU - Meyers, Rachel
AU  - Meyers R
FAU - Nochur, Saraswathy
AU  - Nochur S
FAU - Harrison, Lisa
AU  - Harrison L
FAU - Meeking, Patricia
AU  - Meeking P
FAU - Mann, Alex
AU  - Mann A
FAU - Moane, Elizabeth
AU  - Moane E
FAU - Oxford, John
AU  - Oxford J
FAU - Pareek, Rajat
AU  - Pareek R
FAU - Moore, Ryves
AU  - Moore R
FAU - Walsh, Ed
AU  - Walsh E
FAU - Studholme, Robert
AU  - Studholme R
FAU - Dorsett, Preston
AU  - Dorsett P
FAU - Alvarez, Rene
AU  - Alvarez R
FAU - Lambkin-Williams, Robert
AU  - Lambkin-Williams R
LA  - eng
GR  - RR 16187/RR/NCRR NIH HHS/United States
GR  - RR00211/RR/NCRR NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20100709
PL  - United States
TA  - Am J Respir Crit Care Med
JT  - American journal of respiratory and critical care medicine
JID - 9421642
RN  - 0 (Chemokines)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-6)
SB  - IM
CIN - Am J Respir Crit Care Med. 2010 Nov 15;182(10):1217-9. PMID: 21079265
MH  - Adolescent
MH  - Adult
MH  - Chemokines/analysis
MH  - Cytokines/analysis
MH  - Female
MH  - Humans
MH  - Interleukin-6/analysis
MH  - Male
MH  - Middle Aged
MH  - Nasal Lavage Fluid/immunology
MH  - Respiratory Syncytial Virus Infections/etiology/*virology
MH  - Respiratory Syncytial Viruses/growth & development/*pathogenicity
MH  - *Viral Load
MH  - Viral Plaque Assay
MH  - Young Adult
PMC - PMC3001267
EDAT- 2010/07/14 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/07/13 06:00
PHST- 2010/07/13 06:00 [entrez]
PHST- 2010/07/14 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 201002-0221OC [pii]
AID - 10.1164/rccm.201002-0221OC [doi]
PST - ppublish
SO  - Am J Respir Crit Care Med. 2010 Nov 15;182(10):1305-14. doi:
      10.1164/rccm.201002-0221OC. Epub 2010 Jul 9.


PMID- 20621881
OWN - NLM
STAT- MEDLINE
DCOM- 20101019
LR  - 20211203
IS  - 1048-2911 (Print)
IS  - 1048-2911 (Linking)
VI  - 20
IP  - 2
DP  - 2010
TI  - Ethics for environmental health research: the case of the U.S. Nuclear weapons
      industry.
PG  - 179-87
LID - 10.2190/NS.20.2.b [doi]
AB  - Exploitation of workers and communities based on class and race has profoundly
      influenced occupational and environmental health. During production and testing
      of nuclear weapons in the United States, class and race have affected exposures
      to radiation and other hazards as well as protection programs and monitoring of
      exposures. This situation has contributed to health disparities and has hindered 
      advancement of research into the health effects of ionizing radiation and other
      exposures from nuclear weapons production. Organizing by workers and affected
      communities can bring about a better understanding of the health effects of
      ionizing radiation as well as more ethical research practices.
FAU - Wing, Steve
AU  - Wing S
AD  - Department of Epidemiology, School of Public Health, University of North Carolina
      at Chapel Hill, NC 27599-2089, USA. steve_wing@unc.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - New Solut
JT  - New solutions : a journal of environmental and occupational health policy : NS
JID - 9100937
SB  - IM
MH  - Environmental Exposure/*prevention & control/statistics & numerical data
MH  - *Ethics, Research
MH  - *Health Status Disparities
MH  - Humans
MH  - *Industry
MH  - *Nuclear Weapons
MH  - Occupational Exposure/prevention & control/statistics & numerical data
MH  - Racial Groups
MH  - Social Class
MH  - United States
EDAT- 2010/07/14 06:00
MHDA- 2010/10/20 06:00
CRDT- 2010/07/13 06:00
PHST- 2010/07/13 06:00 [entrez]
PHST- 2010/07/14 06:00 [pubmed]
PHST- 2010/10/20 06:00 [medline]
AID - B30737008883330M [pii]
AID - 10.2190/NS.20.2.b [doi]
PST - ppublish
SO  - New Solut. 2010;20(2):179-87. doi: 10.2190/NS.20.2.b.


PMID- 20621009
OWN - NLM
STAT- MEDLINE
DCOM- 20100929
LR  - 20100712
IS  - 1553-4650 (Print)
IS  - 1553-4650 (Linking)
VI  - 17
IP  - 4
DP  - 2010 Jul-Aug
TI  - Laparoscopic peritoneal entry with the reusable threaded visual cannula.
PG  - 461-7
LID - 10.1016/j.jmig.2010.03.001 [doi]
AB  - STUDY OBJECTIVE: To estimate the feasibility, reproducibility, and safety of
      laparoscopic port establishment using a trocarless and externally threaded visual
      cannula (TVC). DESIGN: Multicentre, prospective, observational study (Canadian
      Task Force classification II-2). SETTING: Three university-affiliated teaching
      hospitals. PATIENTS: Four thousand seven hundred twenty-four women (median age,
      34 years; median body mass index, 25) underwent laparoscopic surgery.
      INTERVENTION: After administration of general anesthesia, the Veress needle was
      inserted at the umbilicus or the left upper quadrant (LUQ) using Veress
      intraperitoneal pressure of 10 mm Hg or less as proxy for correct placement.
      Transient high intraperitoneal pressure of 20 to 30 mm Hg was attained, and
      primary and ancillary ports were established using the reusable trocarless TVC.
      MEASUREMENTS AND MAIN RESULTS: Institutional research ethics board approval and
      patient consent for video capture were obtained. Primary umbilical entry was
      established in 4598 patients (97.33%), primary LUQ entry in 123 (2.60%), and
      primary suprapubic entry in 3 (0.06%) patients. Peritoneal preinsufflation was
      abandoned when 3 consecutive umbilical or LUQ Veress needle insertion attempts
      failed. Some patients at high risk with known peritoneal adhesions or previous
      lower abdominal midline scars did not undergo preinsufflation, and the trocarless
      TVC was applied directly. Surgery was postponed in 3 patients in whom
      insufflation failed, to enable further counseling and appropriate consenting.
      There were no serious abdominal wall or intraabdominal vascular injuries. One
      transverse colon, densely adhered to the umbilical region, was injured, which was
      recognized and repaired intraoperatively. Residents, fellows, or faculty recorded
      entry-related data on forms postoperatively for study and analysis. CONCLUSIONS: 
      Establishing peritoneal ports with the trocarless TVC is feasible, reproducible, 
      and seems to be highly adoptable.
CI  - Copyright (c) 2010 AAGL. Published by Elsevier Inc. All rights reserved.
FAU - Ternamian, Artin M
AU  - Ternamian AM
AD  - Department of Obstetrics and Gynecology, Division of Gynecologic Endoscopy, St.
      Joseph's Health Centre, University of Toronto, Toronto Ontario, Canada.
      artin.ternamian@utoronto.ca
FAU - Vilos, George A
AU  - Vilos GA
FAU - Vilos, Angelos G
AU  - Vilos AG
FAU - Abu-Rafea, Basim
AU  - Abu-Rafea B
FAU - Tyrwhitt, Jessica
AU  - Tyrwhitt J
FAU - MacLeod, Natalie T
AU  - MacLeod NT
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - United States
TA  - J Minim Invasive Gynecol
JT  - Journal of minimally invasive gynecology
JID - 101235322
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Insufflation
MH  - *Laparoscopes
MH  - *Laparoscopy
MH  - Middle Aged
MH  - Peritoneal Cavity/*surgery
MH  - Prospective Studies
MH  - Young Adult
EDAT- 2010/07/14 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/07/13 06:00
PHST- 2009/09/02 00:00 [received]
PHST- 2010/02/26 00:00 [revised]
PHST- 2010/03/06 00:00 [accepted]
PHST- 2010/07/13 06:00 [entrez]
PHST- 2010/07/14 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - S1553-4650(10)00113-5 [pii]
AID - 10.1016/j.jmig.2010.03.001 [doi]
PST - ppublish
SO  - J Minim Invasive Gynecol. 2010 Jul-Aug;17(4):461-7. doi:
      10.1016/j.jmig.2010.03.001.


PMID- 20620765
OWN - NLM
STAT- MEDLINE
DCOM- 20100810
LR  - 20220330
IS  - 1097-6809 (Electronic)
IS  - 0741-5214 (Linking)
VI  - 52
IP  - 1
DP  - 2010 Jul
TI  - An analysis of drug modulation of abdominal aortic aneurysm growth through 25
      years of surveillance.
PG  - 55-61.e2
LID - 10.1016/j.jvs.2010.02.012 [doi]
AB  - BACKGROUND: A modest (41%) reduction in abdominal aortic aneurysm (AAA) growth
      rate is likely to delay AAA-related events (surgery or rupture) by 5 years,
      making the notion of AAA medical treatment very appealing. Randomized controlled 
      trials of commonly used existing medications are expensive and ethically
      questionable. This study reviewed the independent associations of commonly used
      medications and AAA growth during a 25-year period of AAA surveillance. METHODS: 
      The study included all patients monitored through an AAA screening and
      surveillance program. Records of AAA size, risk factors, outcomes, death, and
      medications were entered into a continually updated database. AAA growth rates
      were calculated using a flexible hierarchical model. A multivariate model was
      used to test for associations independent of confounders. RESULTS: The study
      comprised 1269 patients (94.1% men) who had a mean age of 67 years. The median
      starting diameter was 35 mm, the end diameter was 44 mm, and follow-up was 3.4
      years. Drugs used in the treatment of diabetes were associated with a 56%
      reduction in AAA growth rate (P = .01) independent of confounding factors,
      including other therapeutic agents (P = .003). Angiotensin-receptor blockers and 
      potassium-sparing diuretics were also associated with slower AAA growth rates,
      although these effects were not independent of all confounders. CONCLUSION:
      Diabetes or its medications, or both, have a negative effect on AAA growth.
      Because of polypharmacy, demonstrating the independent effects of individual
      drugs affecting the renin-angiotensin system was not possible. In light of this
      analysis, however, strong associations between angiotensin-receptor blockers and 
      aldosterone-receptor blockers and slowed AAA progression are credible.
CI  - Copyright (c) 2010 Society for Vascular Surgery. Published by Mosby, Inc. All
      rights reserved.
FAU - Thompson, Andrew
AU  - Thompson A
AD  - Vascular Surgery Department, Western Sussex Hospitals NHS Trust, Chichester,
      United Kingdom.
FAU - Cooper, Jackie A
AU  - Cooper JA
FAU - Fabricius, Michael
AU  - Fabricius M
FAU - Humphries, Steve E
AU  - Humphries SE
FAU - Ashton, Hilary A
AU  - Ashton HA
FAU - Hafez, Hany
AU  - Hafez H
LA  - eng
GR  - RG/08/008/25291/BHF_/British Heart Foundation/United Kingdom
PT  - Journal Article
PL  - United States
TA  - J Vasc Surg
JT  - Journal of vascular surgery
JID - 8407742
SB  - IM
MH  - Aged
MH  - Aorta, Abdominal/diagnostic imaging/*drug effects
MH  - Aortic Aneurysm, Abdominal/diagnostic imaging/*drug therapy/mortality
MH  - Dilatation, Pathologic
MH  - Disease Progression
MH  - Drug Prescriptions
MH  - Female
MH  - Humans
MH  - Male
MH  - Markov Chains
MH  - *Mass Screening/methods
MH  - Models, Statistical
MH  - Monte Carlo Method
MH  - Multivariate Analysis
MH  - Polypharmacy
MH  - Risk Assessment
MH  - Risk Factors
MH  - Time Factors
MH  - Ultrasonography
EDAT- 2010/07/14 06:00
MHDA- 2010/08/11 06:00
CRDT- 2010/07/13 06:00
PHST- 2009/09/12 00:00 [received]
PHST- 2010/02/02 00:00 [revised]
PHST- 2010/02/03 00:00 [accepted]
PHST- 2010/07/13 06:00 [entrez]
PHST- 2010/07/14 06:00 [pubmed]
PHST- 2010/08/11 06:00 [medline]
AID - S0741-5214(10)00307-1 [pii]
AID - 10.1016/j.jvs.2010.02.012 [doi]
PST - ppublish
SO  - J Vasc Surg. 2010 Jul;52(1):55-61.e2. doi: 10.1016/j.jvs.2010.02.012.


PMID- 20620531
OWN - NLM
STAT- MEDLINE
DCOM- 20101029
LR  - 20100712
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 42
IP  - 5
DP  - 2010 Jun
TI  - Low survival rate of renal transplant recipients from unrelated living donors
      with renal diseases.
PG  - 1822-4
LID - 10.1016/j.transproceed.2010.01.053 [doi]
AB  - In three hospitals within a restricted area in Japan in November, 2006, 42
      patients were revealed to have received kidneys transplanted from unrelated
      living donors who displayed renal diseases. All of these cases were performed by 
      one doctor without any ethical discussion in the hospitals nor any reports to the
      public. Almost all medical records were discarded legally in two hospitals. Only 
      one hospital, Uwajima City Hospital, kept the almost complete records including
      the survivals of 25 cases. The Japan Society for Transplantation was asked to
      analyze these cases leading to this report on the long-term outcome of cases at
      Uwajima City Hospital. The diseased kidney grafts were procured in four
      hospitals. The cases of removal of the kidneys from the donors were malignant
      diseases (n = 11) or benign diseases (n = 14). The survival rates of the donors
      were 86.1% at 1, 70.8% at 5, and 57.7% at 10 years. The survival rates of the
      recipients transplanted from donors with malignant versus benign diseases were
      80.8% versus 92.3% in 1, 48.5% versus 84.6% at 5% and 48.5% versus 76.2% at 10
      years, respectively. The survival rates of the grafts from donors with malignant 
      versus benign diseases were 71.6% versus 71.4% at 1, 15.3% versus 50.0% at 5, and
      15.3% versus 33.3% at 10 years, respectively. In conclusion, we have reported
      herein the low survival rates of renal transplantation recipients and grafts from
      unrelated living donors with preexistent renal diseases.
FAU - Takahara, S
AU  - Takahara S
AD  - Department of Advanced Technology for Transplantation, Osaka University Graduate 
      School of Medicine, Osaka, Japan.
FAU - Yuzawa, K
AU  - Yuzawa K
CN  - Japan Society for Transplantation
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - Carcinoma, Renal Cell/surgery
MH  - Graft Survival/physiology
MH  - Humans
MH  - Kidney/abnormalities
MH  - Kidney Diseases/*surgery
MH  - Kidney Neoplasms/surgery
MH  - Kidney Transplantation/mortality/*pathology
MH  - Living Donors/*statistics & numerical data
MH  - Nephrotic Syndrome/surgery
MH  - Survival Rate
MH  - Time Factors
EDAT- 2010/07/14 06:00
MHDA- 2010/10/30 06:00
CRDT- 2010/07/13 06:00
PHST- 2008/01/21 00:00 [received]
PHST- 2008/05/13 00:00 [revised]
PHST- 2010/01/28 00:00 [accepted]
PHST- 2010/07/13 06:00 [entrez]
PHST- 2010/07/14 06:00 [pubmed]
PHST- 2010/10/30 06:00 [medline]
AID - S0041-1345(10)00484-7 [pii]
AID - 10.1016/j.transproceed.2010.01.053 [doi]
PST - ppublish
SO  - Transplant Proc. 2010 Jun;42(5):1822-4. doi: 10.1016/j.transproceed.2010.01.053.


PMID- 20620396
OWN - NLM
STAT- MEDLINE
DCOM- 20100824
LR  - 20181201
IS  - 1527-3792 (Electronic)
IS  - 0022-5347 (Linking)
VI  - 184
IP  - 2
DP  - 2010 Aug
TI  - Ramon Guiteras: founder of the American Urological Association, surgeon,
      sportsman and statesman.
PG  - 447-52
LID - 10.1016/j.juro.2010.03.146 [doi]
AB  - PURPOSE: We conducted an extensive search to learn more about Ramon Guiteras, the
      founder of the American Urological Association. MATERIALS AND METHODS: Scientific
      publications, newspaper articles, and historical documents and texts were
      reviewed. Institutions and organizations of which Ramon Guiteras was a member
      were contacted. RESULTS: Guiteras' career peaked at the turn of the century, just
      as genitourinary surgery was emerging as an independent field. The American
      Urological Association began as an organization of the members of Guiteras'
      clinic with the dream of becoming an inclusive organization for the benefit of
      all ethical physicians with an interest in the urinary sciences. Guiteras
      contributed to advances in urological treatments, including improving and helping
      to bring a method of suprapubic prostatectomy to worldwide attention. He authored
      numerous scientific articles and a comprehensive, fully illustrated, 2-volume
      textbook that was widely translated. He pursued adventure through travel and
      sport, and participated in missions to Cuba and France during President Wilson's 
      term of office. CONCLUSIONS: Ramon Guiteras died at age 59 years but his legacy
      lives on through the American Urological Association, a detailed textbook,
      contributions to urological instruments and techniques, and a vibrant elementary 
      school in Bristol, Rhode Island that bears his name.
CI  - Copyright (c) 2010 American Urological Association Education and Research, Inc.
      Published by Elsevier Inc. All rights reserved.
FAU - Crane, Genevieve M
AU  - Crane GM
AD  - Department of Urology, Lahey Clinic, Burlington, Massachusetts 01805, USA.
      eve945@gmail.com
FAU - Bloom, David A
AU  - Bloom DA
LA  - eng
PT  - Biography
PT  - Historical Article
PT  - Journal Article
PT  - Portrait
DEP - 20100617
PL  - United States
TA  - J Urol
JT  - The Journal of urology
JID - 0376374
SB  - IM
MH  - Boxing/*history
MH  - General Surgery/*history
MH  - Government/*history
MH  - History, 19th Century
MH  - History, 20th Century
MH  - Rhode Island
MH  - Societies, Medical/*history
MH  - United States
MH  - Urology/*history
PS  - Guiteras RB
FPS - Guiteras, Ramon Benjamin
EDAT- 2010/07/14 06:00
MHDA- 2010/08/25 06:00
CRDT- 2010/07/13 06:00
PHST- 2009/12/15 00:00 [received]
PHST- 2010/07/13 06:00 [entrez]
PHST- 2010/07/14 06:00 [pubmed]
PHST- 2010/08/25 06:00 [medline]
AID - S0022-5347(10)03274-X [pii]
AID - 10.1016/j.juro.2010.03.146 [doi]
PST - ppublish
SO  - J Urol. 2010 Aug;184(2):447-52. doi: 10.1016/j.juro.2010.03.146. Epub 2010 Jun
      17.


PMID- 20620300
OWN - NLM
STAT- MEDLINE
DCOM- 20101021
LR  - 20100712
IS  - 1531-5037 (Electronic)
IS  - 0022-3468 (Linking)
VI  - 45
IP  - 6
DP  - 2010 Jun
TI  - Is congenital cystic adenomatoid malformation a premalignant lesion for
      pleuropulmonary blastoma?
PG  - 1086-9
LID - 10.1016/j.jpedsurg.2010.02.067 [doi]
AB  - BACKGROUND: The relationship between congenital cystic adenomatoid malformation
      (CCAM) and pleuropulmonary blastoma (PPB), whether causal, correlational, or
      coincidental, remains controversial. There is a lack of consensus as to the
      optimal treatment of patients with asymptomatic CCAM. METHOD: We reviewed all
      cases of CCAM and PPB seen at our institution from 1999 to 2008. Institutional
      Research Ethics Board approval was obtained. The incidence of CCAM and PPB,
      respectively, was calculated based on birth numbers during the study period.
      RESULTS: Seventy-four CCAMs were resected over the study period in 129 children
      diagnosed with CCAM. Five PPBs were diagnosed during the study period. Three of
      the 5 PPB cases were initially diagnosed as CCAMs. These PPBs were not clinically
      or radiologically distinguishable from CCAMs. In our referral area, the incidence
      of CCAM was 1 in 12,000; and the incidence of PPB was 1 in 250,000 live births.
      The mortality rate for PPB in this cohort was 20%. CONCLUSION: Asymptomatic
      cystic lung malformations represent a therapeutic dilemma. In this cohort, the
      incidence of PPB among apparently benign lung lesions was 4%. No clinical or
      radiological markers differentiated benign CCAMs from PPBs. Our experience
      provides further justification for resection of all CCAMs. This should be
      discussed with parents until CCAMs and PPBs can be clearly distinguished
      preoperatively.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Nasr, Ahmed
AU  - Nasr A
AD  - Division of General and Thoracic Surgery, The Hospital for Sick Children,
      Toronto, Ontario, Canada M5G1X8.
FAU - Himidan, Sharifa
AU  - Himidan S
FAU - Pastor, Aimee C
AU  - Pastor AC
FAU - Taylor, Glenn
AU  - Taylor G
FAU - Kim, Peter C W
AU  - Kim PC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Pediatr Surg
JT  - Journal of pediatric surgery
JID - 0052631
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Combined Modality Therapy
MH  - Cystic Adenomatoid Malformation of Lung,
      Congenital/epidemiology/*pathology/therapy
MH  - Diagnosis, Differential
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Incidence
MH  - Infant
MH  - Lung Neoplasms/epidemiology/*pathology/therapy
MH  - Male
MH  - Ontario/epidemiology
MH  - *Precancerous Conditions
MH  - Prevalence
MH  - Prognosis
MH  - Pulmonary Blastoma/epidemiology/*pathology/therapy
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Survival Rate/trends
EDAT- 2010/07/14 06:00
MHDA- 2010/10/22 06:00
CRDT- 2010/07/13 06:00
PHST- 2010/01/18 00:00 [received]
PHST- 2010/02/22 00:00 [accepted]
PHST- 2010/07/13 06:00 [entrez]
PHST- 2010/07/14 06:00 [pubmed]
PHST- 2010/10/22 06:00 [medline]
AID - S0022-3468(10)00186-7 [pii]
AID - 10.1016/j.jpedsurg.2010.02.067 [doi]
PST - ppublish
SO  - J Pediatr Surg. 2010 Jun;45(6):1086-9. doi: 10.1016/j.jpedsurg.2010.02.067.


PMID- 20619520
OWN - NLM
STAT- MEDLINE
DCOM- 20101102
LR  - 20220316
IS  - 1873-7811 (Electronic)
IS  - 0272-7358 (Linking)
VI  - 30
IP  - 6
DP  - 2010 Aug
TI  - Use of ecological momentary assessment in mood disorders research.
PG  - 794-804
LID - 10.1016/j.cpr.2010.06.007 [doi]
AB  - Ecological momentary assessment (EMA) entails repeated, intensive sampling of
      respondents' current experiences while they are engaged in their typical daily
      routines, in their natural environments. In this article we discuss benefits of
      using EMA techniques in mood disorders research, provide an overview of the
      various specific EMA techniques that have been used with mood-disordered
      populations to date, and summarize the diverse range of research questions that
      EMA has been used to explore in this field. In addition, we evaluate the
      feasibility and acceptability of using EMA techniques with this population and
      suggest additional areas that might be fruitful to investigate, with a focus on
      the extension of EMA techniques into treatment research. Overall, data suggest
      that using EMA techniques in mood disorders research is feasible, generally
      acceptable, and highly promising. We conclude with a discussion of caveats,
      limitations, and ethical considerations.
CI  - Copyright 2010 Elsevier Ltd. All rights reserved.
FAU - Wenze, Susan J
AU  - Wenze SJ
AD  - Psychosocial Research Program, Warren Alpert Medical School of Brown University
      and Butler Hospital, Providence, RI 02906, USA. susan_wenze@brown.edu
FAU - Miller, Ivan W
AU  - Miller IW
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100625
PL  - United States
TA  - Clin Psychol Rev
JT  - Clinical psychology review
JID - 8111117
SB  - IM
MH  - Humans
MH  - Mood Disorders/*psychology
MH  - *Research Design
MH  - Self-Assessment
MH  - Severity of Illness Index
EDAT- 2010/07/14 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/07/13 06:00
PHST- 2009/10/23 00:00 [received]
PHST- 2010/06/09 00:00 [revised]
PHST- 2010/06/18 00:00 [accepted]
PHST- 2010/07/13 06:00 [entrez]
PHST- 2010/07/14 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - S0272-7358(10)00101-7 [pii]
AID - 10.1016/j.cpr.2010.06.007 [doi]
PST - ppublish
SO  - Clin Psychol Rev. 2010 Aug;30(6):794-804. doi: 10.1016/j.cpr.2010.06.007. Epub
      2010 Jun 25.


PMID- 20618929
OWN - NLM
STAT- MEDLINE
DCOM- 20100929
LR  - 20220408
IS  - 1472-6920 (Electronic)
IS  - 1472-6920 (Linking)
VI  - 10
DP  - 2010 Jul 9
TI  - The learners' perspective on internal medicine ward rounds: a cross-sectional
      study.
PG  - 53
LID - 10.1186/1472-6920-10-53 [doi]
AB  - BACKGROUND: Ward rounds form an integral part of Internal Medicine teaching. This
      study aimed to determine the trainees' opinions regarding various aspects of
      their ward rounds, including how well they cover their learning needs, how they
      would like the rounds to be conducted, and differences of opinion between medical
      students and postgraduates. METHODS: A cross-sectional study was conducted on a
      total of 134 trainees in Internal Medicine, comprising medical students, interns,
      residents and fellows, who were asked to fill in a structured, self-designed
      questionnaire. Most of the responses required a rating on a scale of 1-5 (1 being
      highly unsatisfactory and 5 being highly satisfactory). RESULTS: Teaching of
      clinical skills and bedside teaching received the lowest overall mean score (Mean
      +/- SD 2.48 +/- 1.02 and 2.49 +/- 1.12 respectively). They were rated much lower 
      by postgraduates as compared to students (p < 0.001). All respondents felt that
      management of patients was the aspect best covered by the current ward rounds
      (Mean +/- SD 3.71 +/- 0.72). For their desired ward rounds, management of
      patients received the highest score (Mean +/- SD 4.64 +/- 0.55), followed by
      bedside examinations (Mean +/- SD 4.60 +/- 0.61) and clinical skills teaching
      (Mean +/- SD 4.50 +/- 0.68). The postgraduates desired a lot more focus on
      communication skills, counselling and medical ethics as compared to students,
      whose primary focus was teaching of bedside examination and management. A
      majority of the respondents (87%) preferred bedside rounds over conference room
      rounds. Even though the duration of rounds was found to be adequate, a majority
      of the trainees (68%) felt there was a lack of individual attention during ward
      rounds. CONCLUSIONS: This study highlights important areas where ward rounds need
      improvement in order to maximize their benefit to the learners. There is a need
      to modify the current state of ward rounds in order to address the needs and
      expectations of trainees.
FAU - Tariq, Muhammad
AU  - Tariq M
AD  - Department of Medicine, Aga Khan University, Karachi, Pakistan.
      muhammed.tariq@aku.edu
FAU - Motiwala, Afaq
AU  - Motiwala A
FAU - Ali, Syed Umer
AU  - Ali SU
FAU - Riaz, Mehmood
AU  - Riaz M
FAU - Awan, Safia
AU  - Awan S
FAU - Akhter, Jaweed
AU  - Akhter J
LA  - eng
PT  - Journal Article
DEP - 20100709
PL  - England
TA  - BMC Med Educ
JT  - BMC medical education
JID - 101088679
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Cross-Sectional Studies
MH  - Education, Medical, Graduate/*methods
MH  - Female
MH  - Humans
MH  - Internal Medicine/*education
MH  - Male
MH  - Physicians/*psychology
MH  - Surveys and Questionnaires
MH  - *Teaching Rounds
PMC - PMC2912319
EDAT- 2010/07/14 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/07/13 06:00
PHST- 2009/10/07 00:00 [received]
PHST- 2010/07/09 00:00 [accepted]
PHST- 2010/07/13 06:00 [entrez]
PHST- 2010/07/14 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - 1472-6920-10-53 [pii]
AID - 10.1186/1472-6920-10-53 [doi]
PST - epublish
SO  - BMC Med Educ. 2010 Jul 9;10:53. doi: 10.1186/1472-6920-10-53.


PMID- 20618821
OWN - NLM
STAT- MEDLINE
DCOM- 20101008
LR  - 20100712
IS  - 1526-4610 (Electronic)
IS  - 0017-8748 (Linking)
VI  - 50
IP  - 6
DP  - 2010 Jun
TI  - Resident and fellow section. Publication ethics--handling two common conundrums
      facing authors and reviewers.
PG  - 1080-6
LID - 10.1111/j.1526-4610.2010.01689.x [doi]
FAU - Levin, Morris
AU  - Levin M
AD  - Section of Neurology Dartmouth Hitchcock Medical Center, Lebanon, NH, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Headache
JT  - Headache
JID - 2985091R
SB  - IM
MH  - Authorship
MH  - Periodicals as Topic/*ethics
MH  - Publishing/*ethics
EDAT- 2010/07/14 06:00
MHDA- 2010/10/12 06:00
CRDT- 2010/07/13 06:00
PHST- 2010/07/13 06:00 [entrez]
PHST- 2010/07/14 06:00 [pubmed]
PHST- 2010/10/12 06:00 [medline]
AID - HED1689 [pii]
AID - 10.1111/j.1526-4610.2010.01689.x [doi]
PST - ppublish
SO  - Headache. 2010 Jun;50(6):1080-6. doi: 10.1111/j.1526-4610.2010.01689.x.


PMID- 20618602
OWN - NLM
STAT- MEDLINE
DCOM- 20101122
LR  - 20220410
IS  - 1547-5069 (Electronic)
IS  - 1527-6546 (Linking)
VI  - 42
IP  - 2
DP  - 2010 Jun
TI  - Relationship between nurses' organizational trust levels and their organizational
      citizenship behaviors.
PG  - 186-94
LID - 10.1111/j.1547-5069.2010.01347.x [doi]
AB  - PURPOSE: This research used a descriptive and explorative design to determine the
      levels of nurses' organizational trust and organizational citizenship and to
      investigate relationships between the levels of organizational trust and
      organizational citizenship behaviors. DESIGN AND METHODS: Nurses who had
      completed their orientation from a total of 11 hospitals with bed capacities of
      100 and located in the European district of Istanbul were included in the sample 
      for this study. Formal, written applications and approval of the ethical
      committee were obtained from concerned institutions before proceeding with the
      data collection step. The Organizational Trust Inventory and the Organizational
      Citizenship Level Scale, a questionnaire form including five questions regarding 
      nurses' personal characteristics, were used in data collection. Data collection
      tools were distributed to 900 nurses in total, and usable data were obtained from
      482 nurses. Number and percentage calculations and Pearson correlation analysis
      were used to assess research data. FINDINGS: The results of the present research 
      showed that nurses had a higher than average level of trust in their managers and
      coworkers and they trusted more in their managers and coworkers than their
      institutions. The Organizational Citizenship Level Scale indicated that the
      behavior most frequently demonstrated by the nurses was conscientiousness,
      followed by courtesy and civic virtue, whereas sportsmanship was displayed to an 
      average extent. An analysis of relationships between nurses' level of
      organizational trust and their organizational citizenship behaviors revealed that
      nurses who trust in their managers, institutions, and coworkers demonstrated the 
      organizational citizenship behaviors of conscientiousness, civic virtue,
      courtesy, and altruism more frequently. CONCLUSIONS: The findings attained in
      this study indicated that the organizational trust the staff had in their
      institutions, managers, and coworkers influenced the organizational citizenship
      behaviors of conscientiousness, civic virtue, altruism, and courtesy, whereas it 
      had no effect on sportsmanship behavior. Nurse managers should introduce studies 
      to improve their subordinates' organizational trust to ensure that they develop
      organizational citizenship behaviors, and they should support them in this
      process. CLINICAL RELEVANCE: These topics for nursing services will provide
      guidance to managers, particularly to managers of nursing services, in
      establishing processes to predict nurses' organizational commitment, job
      satisfaction, performance, intention to leave, and other relevant issues.
FAU - Altuntas, Serap
AU  - Altuntas S
AD  - Faculty of Health Sciences, Nursing Management Department, Ataturk University,
      Erzurum, Turkey. serap342002@yahoo.com
FAU - Baykal, Ulku
AU  - Baykal U
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Nurs Scholarsh
JT  - Journal of nursing scholarship : an official publication of Sigma Theta Tau
      International Honor Society of Nursing
JID - 100911591
SB  - IM
MH  - Altruism
MH  - *Attitude of Health Personnel
MH  - Conscience
MH  - Cooperative Behavior
MH  - Health Facility Environment/organization & administration
MH  - Hospital Bed Capacity, 100 to 299
MH  - Humans
MH  - *Interprofessional Relations
MH  - Job Satisfaction
MH  - Nurse Administrators/organization & administration/psychology
MH  - Nursing Methodology Research
MH  - *Nursing Staff, Hospital/organization & administration/psychology
MH  - Organizational Culture
MH  - Peer Group
MH  - *Personnel Loyalty
MH  - Professional Competence
MH  - Social Responsibility
MH  - Surveys and Questionnaires
MH  - Trust/*psychology
MH  - Turkey
MH  - Virtues
EDAT- 2010/07/14 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/07/13 06:00
PHST- 2010/07/13 06:00 [entrez]
PHST- 2010/07/14 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - JNU1347 [pii]
AID - 10.1111/j.1547-5069.2010.01347.x [doi]
PST - ppublish
SO  - J Nurs Scholarsh. 2010 Jun;42(2):186-94. doi: 10.1111/j.1547-5069.2010.01347.x.


PMID- 20618240
OWN - NLM
STAT- MEDLINE
DCOM- 20100929
LR  - 20161125
IS  - 1479-828X (Electronic)
IS  - 0004-8666 (Linking)
VI  - 50
IP  - 3
DP  - 2010 Jun
TI  - Complementary roles of prenatal sonography and magnetic resonance imaging in
      diagnosis of fetal renal anomalies.
PG  - 237-41
LID - 10.1111/j.1479-828X.2010.01153.x [doi]
AB  - OBJECTIVES: This study was designed to assess the role of magnetic resonance
      imaging (MRI) in refining the diagnosis of prenatally suspected fetal renal
      abnormalities following screening ultrasound. PATIENTS AND METHODS: Twenty
      pregnant women, with suspected fetal renal abnormality detected during screening 
      ultrasound and more than 14 weeks' gestation, were included in this observational
      prospective study at Ain Shams University Maternity Hospital from March 2004 to
      March 2005 after informed consent and after approval of the study protocol by the
      institute ethics committee. RESULTS: The MRI could diagnose correctly 10 cases of
      hydronephrosis, one case of polycystic kidney disease (PCKD), one case of RA, two
      normal case and two cases of intra-abdominal masses (IA Mass) (16 of 18 cases).
      The prenatal ultrasound could diagnose correctly eight cases of hydronephrosis,
      one case of PCKD, one case of renal agenesis, one case of multicystic kidney
      disease and one case of IA Mass (12 of 18 cases). The prenatal ultrasound and MRI
      gave different diagnoses in eight cases and gave the same diagnosis in 12 cases. 
      The MRI could diagnose the aetiology of congenital renal cysts in 10 of the 20
      studied cases (50%). CONCLUSION: Magnetic resonance imaging can be used as a
      complementary tool in the assessment of sonographically suspected fetal renal
      anomalies.
FAU - Abdelazim, Ibrahim A
AU  - Abdelazim IA
AD  - Department of Obstetrics and Gynaecology, Ain Shams University, Cairo, Egypt.
      dr-ibrahimanwar@hotmail.com
FAU - Abdelrazak, Khaled M
AU  - Abdelrazak KM
FAU - Ramy, Ahmed R M
AU  - Ramy AR
FAU - Mounib, Ahmed M
AU  - Mounib AM
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - Australia
TA  - Aust N Z J Obstet Gynaecol
JT  - The Australian & New Zealand journal of obstetrics & gynaecology
JID - 0001027
SB  - IM
MH  - Female
MH  - Fetal Diseases/*diagnosis/diagnostic imaging
MH  - Humans
MH  - Kidney/*abnormalities
MH  - *Magnetic Resonance Imaging
MH  - Mass Screening
MH  - Pregnancy
MH  - Prospective Studies
MH  - *Ultrasonography, Prenatal
MH  - Urogenital Abnormalities/*diagnosis/diagnostic imaging
EDAT- 2010/07/14 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/07/13 06:00
PHST- 2010/07/13 06:00 [entrez]
PHST- 2010/07/14 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - AJO1153 [pii]
AID - 10.1111/j.1479-828X.2010.01153.x [doi]
PST - ppublish
SO  - Aust N Z J Obstet Gynaecol. 2010 Jun;50(3):237-41. doi:
      10.1111/j.1479-828X.2010.01153.x.


PMID- 20618081
OWN - NLM
STAT- MEDLINE
DCOM- 20110407
LR  - 20181201
IS  - 1937-335X (Electronic)
IS  - 1937-3341 (Linking)
VI  - 16
IP  - 12
DP  - 2010 Dec
TI  - Biochemical and biophysical analyses of tissue-engineered bone obtained from
      three-dimensional culture of a subset of bone marrow mesenchymal stem cells.
PG  - 3657-67
LID - 10.1089/ten.TEA.2009.0750 [doi]
AB  - Grafts of tissue-engineered bone represent a promising alternative in the
      treatment of large and small bone defects. Current approaches are often badly
      tolerated by patients because of invasiveness, ethical problems, culture, and
      possibility of infection. Autologous grafts have been indicated as a solution to 
      such problems. Because of tissue availability, many have proposed the use of
      cultured cells derived from bone marrow expanded in culture and induced to
      differentiate in bone tissue. Data reported in the literature show that it is
      possible to produce tissue substitutes in vitro indeed, but results are not
      always concordant regarding the in vitro produced bone quality. In the present
      work, we investigated bone formation in aggregates of human bone marrow-derived
      mesenchymal stem cells induced to differentiate in bone. After osteoinduction we 
      characterized the mineral matrix produced using Fourier transform infrared
      spectroscopy, scanning electron microscopy, transmission electron microscopy, and
      X-ray powder diffraction. Cells were obtained from bone marrow, subjected to
      immunodepletion for CD3, CD11b, CD14, CD16, CD19, CD56, CD66b, and glycophorin A 
      using RosetteSep and cultured in a new formulation of medium for four passages
      and then were allowed to form spontaneous aggregates. At the end of proliferation
      before aggregation, cells were analyzed by fluorescent activated cell sorting
      (FACS) for markers routinely used to characterize expanded mesenchymal stem cells
      and were found to be remarkably homogeneous for CD29 (99% +/- 1%), CD73 (99% +/- 
      1%), CD90 (95% +/- 4%), CD105 (96% +/- 4%), and CD133 (0% +/- 1%) expression. Our
      results show that not only aggregated cells express the major markers of
      osteogenic differentiation, such as osteocalcin, osteonectin, osteopontin, and
      bone sialoprotein, but also the inorganic matrix is made of an apatite
      structurally and morphologically similar to native bone even without a scaffold.
FAU - Ferro, Federico
AU  - Ferro F
AD  - Dipartimento di Patologia e Medicina Sperimentale e Clinica, University of Udine,
      Udine, Italy.
FAU - Falini, Giuseppe
AU  - Falini G
FAU - Spelat, Renza
AU  - Spelat R
FAU - D'Aurizio, Federica
AU  - D'Aurizio F
FAU - Puppato, Elisa
AU  - Puppato E
FAU - Pandolfi, Maura
AU  - Pandolfi M
FAU - Beltrami, Antonio Paolo
AU  - Beltrami AP
FAU - Cesselli, Daniela
AU  - Cesselli D
FAU - Beltrami, Carlo Alberto
AU  - Beltrami CA
FAU - Impiombato, Francesco Saverio Ambesi
AU  - Impiombato FS
FAU - Curcio, Francesco
AU  - Curcio F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100830
PL  - United States
TA  - Tissue Eng Part A
JT  - Tissue engineering. Part A
JID - 101466659
SB  - IM
MH  - Bone Marrow Cells/*cytology/*metabolism/ultrastructure
MH  - Cell Differentiation/physiology
MH  - Cells, Cultured
MH  - Flow Cytometry
MH  - Humans
MH  - Immunoblotting
MH  - Immunohistochemistry
MH  - Mesenchymal Stem Cells/*cytology/*metabolism/ultrastructure
MH  - Microscopy, Electron, Scanning
MH  - Microscopy, Electron, Transmission
MH  - Osteoblasts/cytology/metabolism/ultrastructure
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Tissue Engineering/*methods
EDAT- 2010/07/14 06:00
MHDA- 2011/04/08 06:00
CRDT- 2010/07/13 06:00
PHST- 2010/07/13 06:00 [entrez]
PHST- 2010/07/14 06:00 [pubmed]
PHST- 2011/04/08 06:00 [medline]
AID - 10.1089/ten.TEA.2009.0750 [doi]
PST - ppublish
SO  - Tissue Eng Part A. 2010 Dec;16(12):3657-67. doi: 10.1089/ten.TEA.2009.0750. Epub 
      2010 Aug 30.


PMID- 20616613
OWN - NLM
STAT- MEDLINE
DCOM- 20101020
LR  - 20100709
IS  - 1423-0291 (Electronic)
IS  - 1015-2008 (Linking)
VI  - 77
IP  - 4
DP  - 2010
TI  - Inter- and intra-biobank networks: classification of biobanks.
PG  - 181-90
LID - 10.1159/000292651 [doi]
AB  - BACKGROUND: Many biobanks have struggled to deliver on the high expectations and 
      claims made for them because of insufficient samples, inadequate infrastructure, 
      cost of establishing and maintaining a large enough resource over the long term, 
      and satisfying legal, ethics and governance requirements. Increasingly, networks 
      have formed to help with the collection, processing, storage, advertising, and
      distribution of samples. However, there are also challenges to establishing and
      maintaining biobank networks. AIM: To classify biobanks in order to better
      understand the problems faced by biobank networking. METHODS: Interviews were
      conducted with principal investigators and/or managers responsible for 33
      biobanks in 9 countries. RESULTS: Biobanks were classified into the following
      categories: 'storage', 'bring-and-share', 'catalogue', 'partnership',
      'contribution' and 'expertise'. CONCLUSION: It was possible to allocate all of
      the biobanks visited to one of the network categories although some fitted better
      than others. Thus, the classification may not be mutually exclusive nor encompass
      all types of biobanks. Many of the governance and operational problems associated
      with the biobanks visited were due to networking functions: either intra- or
      inter-biobank networks. Thus, this proposed classification system should help
      better understand these issues and identify solutions.
FAU - Shickle, Darren
AU  - Shickle D
AD  - Academic Unit of Public Health, Institute of Health Sciences, University of
      Leeds, Leeds, UK. d.shickle@leeds.ac.uk
FAU - Griffin, Marcus
AU  - Griffin M
FAU - El-Arifi, Karen
AU  - El-Arifi K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100707
PL  - Switzerland
TA  - Pathobiology
JT  - Pathobiology : journal of immunopathology, molecular and cellular biology
JID - 9007504
SB  - IM
MH  - Biological Specimen Banks/*classification
MH  - *Databases, Genetic
MH  - Europe
MH  - *Genetic Research
MH  - Humans
MH  - Tissue Banks/classification
EDAT- 2010/07/10 06:00
MHDA- 2010/10/21 06:00
CRDT- 2010/07/10 06:00
PHST- 2009/09/28 00:00 [received]
PHST- 2010/01/22 00:00 [accepted]
PHST- 2010/07/10 06:00 [entrez]
PHST- 2010/07/10 06:00 [pubmed]
PHST- 2010/10/21 06:00 [medline]
AID - 000292651 [pii]
AID - 10.1159/000292651 [doi]
PST - ppublish
SO  - Pathobiology. 2010;77(4):181-90. doi: 10.1159/000292651. Epub 2010 Jul 7.


PMID- 20616563
OWN - NLM
STAT- MEDLINE
DCOM- 20101104
LR  - 20111117
IS  - 1660-2862 (Electronic)
IS  - 1660-2854 (Linking)
VI  - 7
IP  - 5
DP  - 2010
TI  - Clinical criteria for the diagnosis of Parkinson's disease.
PG  - 284-90
LID - 10.1159/000314478 [doi]
AB  - The diagnosis of Parkinson's disease (PD) follows the UK Brain Bank Criteria,
      which demands bradykinesia and one additional symptom, i.e. rigidity, resting
      tremor or postural instability. The latter is not a useful sign for the early
      diagnosis of PD, because it does not appear before Hoehn and Yahr stage 3. Early 
      symptoms of PD which precede the onset of motor symptoms are hyposmia, REM sleep 
      behavioral disorder, constipation, and depression. In addition, an increasing
      number of patients whose PD is related to a genetic defect are being described.
      Thus, genetic testing may eventually develop into a tool to identify at-risk
      patients. The clinical diagnosis of PD can be supported by levodopa or
      apomorphine tests. Imaging studies such as cranial CT or MRI are helpful to
      distinguish idiopathic PD from atypical or secondary PD. SPECT and PET methods
      are valuable to distinguish PD tremor from essential tremor if this is clinically
      not possible. Using all of these methods, we may soon be able to make a premotor 
      diagnosis of PD, which will raise the question whether early treatment is
      possible and ethically and clinically advisable.
CI  - Copyright 2010 S. Karger AG, Basel.
FAU - Reichmann, Heinz
AU  - Reichmann H
AD  - Klinik und Poliklinik fur Neurologie, Universitatsklinikum Carl Gustav Carus,
      Dresden, Germany. heinz.reichmann@mailbox.tu-dresden.de
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100709
PL  - Switzerland
TA  - Neurodegener Dis
JT  - Neuro-degenerative diseases
JID - 101189034
SB  - IM
MH  - Clinical Laboratory Techniques
MH  - Diagnostic Imaging
MH  - Early Diagnosis
MH  - Humans
MH  - Movement/physiology
MH  - Parkinson Disease/*diagnosis/genetics/physiopathology/therapy
MH  - Point-of-Care Systems
EDAT- 2010/07/10 06:00
MHDA- 2010/11/05 06:00
CRDT- 2010/07/10 06:00
PHST- 2010/07/10 06:00 [entrez]
PHST- 2010/07/10 06:00 [pubmed]
PHST- 2010/11/05 06:00 [medline]
AID - 000314478 [pii]
AID - 10.1159/000314478 [doi]
PST - ppublish
SO  - Neurodegener Dis. 2010;7(5):284-90. doi: 10.1159/000314478. Epub 2010 Jul 9.


PMID- 20616524
OWN - NLM
STAT- MEDLINE
DCOM- 20101222
LR  - 20100907
IS  - 1661-5433 (Electronic)
IS  - 1661-5425 (Linking)
VI  - 4
IP  - 4-5
DP  - 2010 Sep
TI  - Ethical guidelines for the clinical management of intersex.
PG  - 300-3
LID - 10.1159/000316232 [doi]
AB  - The clinical management of intersex has undergone a significant change in values.
      Whereas in former times, benevolent medical paternalism was the rule, today, the 
      patient's right to respect for dignity and self-determination is given priority. 
      This paper discusses ethical considerations shaping the modern therapeutic
      management of intersex conditions that do not entail acute health risks. It
      concludes with basic ethical guidelines for clinical practice.
FAU - Wiesemann, C
AU  - Wiesemann C
AD  - Department of Medical Ethics and History of Medicine, University of Goettingen,
      Goettingen, Germany. cwiesem@gwdg.de
LA  - eng
PT  - Journal Article
DEP - 20100710
PL  - Switzerland
TA  - Sex Dev
JT  - Sexual development : genetics, molecular biology, evolution, endocrinology,
      embryology, and pathology of sex determination and differentiation
JID - 101316472
SB  - IM
MH  - Disorders of Sex Development/*therapy
MH  - *Ethics, Medical
MH  - Humans
MH  - *Practice Guidelines as Topic
EDAT- 2010/07/10 06:00
MHDA- 2010/12/24 06:00
CRDT- 2010/07/10 06:00
PHST- 2010/07/10 06:00 [entrez]
PHST- 2010/07/10 06:00 [pubmed]
PHST- 2010/12/24 06:00 [medline]
AID - 000316232 [pii]
AID - 10.1159/000316232 [doi]
PST - ppublish
SO  - Sex Dev. 2010 Sep;4(4-5):300-3. doi: 10.1159/000316232. Epub 2010 Jul 10.


PMID- 20615243
OWN - NLM
STAT- MEDLINE
DCOM- 20110301
LR  - 20211020
IS  - 1465-542X (Electronic)
IS  - 1465-5411 (Linking)
VI  - 12
IP  - 4
DP  - 2010
TI  - Mammostrat as a tool to stratify breast cancer patients at risk of recurrence
      during endocrine therapy.
PG  - R47
LID - 10.1186/bcr2604 [doi]
AB  - INTRODUCTION: Patients with early-stage breast cancer, treated with endocrine
      therapy, have approximately 90% 5-year disease-free survival. However, for
      patients at higher risk of relapse despite endocrine therapy, additional adjuvant
      therapy, such as chemotherapy, may be indicated. The challenge is to
      prospectively identify such patients. The Mammostrat(R) test uses five
      immunohistochemical markers to stratify patients on tamoxifen therapy into risk
      groups to inform treatment decisions. We tested the efficacy of this panel in a
      mixed population of cases treated in a single center with breast-conserving
      surgery and long-term follow-up. METHODS: Tissue microarrays from a consecutive
      series (1981 to 1998) of 1,812 women managed by wide local excision and
      postoperative radiotherapy were collected following appropriate ethical review.
      Of 1,390 cases stained, 197 received no adjuvant hormonal or chemotherapy, 1,044 
      received tamoxifen only, and 149 received a combination of hormonal therapy and
      chemotherapy. Median age at diagnosis was 57, 71% were postmenopausal, 23.9% were
      node-positive and median tumor size was 1.5 cm. Samples were stained using
      triplicate 0.6 mm2 tissue microarray cores, and positivity for p53, HTF9C,
      CEACAM5, NDRG1 and SLC7A5 was assessed. Each case was assigned a Mammostrat risk 
      score, and distant recurrence-free survival (DRFS), relapse-free survival (RFS)
      and overall survival (OS) were analyzed by marker positivity and risk score.
      RESULTS: Increased Mammostrat scores were significantly associated with reduced
      DRFS, RFS and OS in estrogen receptor (ER)-positive breast cancer (P < 0.00001). 
      In multivariate analyses the risk score was independent of conventional risk
      factors for DRFS, RFS and OS (P < 0.05). In node-negative, tamoxifen-treated
      patients, 10-year recurrence rates were 7.6 +/- 1.5% in the low-risk group versus
      20.0 +/- 4.4% in the high-risk group. Further, exploratory analyses revealed
      associations with outcome in both ER-negative and untreated patients.
      CONCLUSIONS: This is the fifth independent study providing evidence that
      Mammostrat can act as an independent prognostic tool for ER-positive,
      tamoxifen-treated breast cancer. In addition, this study revealed for the first
      time a possible association with outcome regardless of node status and
      ER-negative tumors. When viewed in the context of previous results, these data
      provide further support for this antibody panel as an aid to patient management
      in early-stage breast cancer.
FAU - Bartlett, John M S
AU  - Bartlett JM
AD  - Endocrine Cancer Group, Edinburgh Cancer Research Centre, Edinburgh University,
      Carrington Crescent, Edinburgh EH4 2XU, UK. john.bartlett@ed.ac.uk
FAU - Thomas, Jeremy
AU  - Thomas J
FAU - Ross, Douglas T
AU  - Ross DT
FAU - Seitz, Robert S
AU  - Seitz RS
FAU - Ring, Brian Z
AU  - Ring BZ
FAU - Beck, Rodney A
AU  - Beck RA
FAU - Pedersen, Hans Christian
AU  - Pedersen HC
FAU - Munro, Alison
AU  - Munro A
FAU - Kunkler, Ian H
AU  - Kunkler IH
FAU - Campbell, Fiona M
AU  - Campbell FM
FAU - Jack, Wilma
AU  - Jack W
FAU - Kerr, Gillian R
AU  - Kerr GR
FAU - Johnstone, Laura
AU  - Johnstone L
FAU - Cameron, David A
AU  - Cameron DA
FAU - Chetty, Udi
AU  - Chetty U
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100708
PL  - England
TA  - Breast Cancer Res
JT  - Breast cancer research : BCR
JID - 100927353
RN  - 0 (Antineoplastic Agents, Hormonal)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (CEACAM5 protein, human)
RN  - 0 (Carcinoembryonic Antigen)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (GPI-Linked Proteins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Large Neutral Amino Acid-Transporter 1)
RN  - 0 (N-myc downstream-regulated gene 1 protein)
RN  - 0 (Receptors, Estrogen)
RN  - 0 (Tumor Suppressor Protein p53)
RN  - 094ZI81Y45 (Tamoxifen)
SB  - IM
MH  - Antineoplastic Agents, Hormonal/therapeutic use
MH  - Biomarkers, Tumor/*metabolism
MH  - Breast Neoplasms/*diagnosis/drug therapy/*metabolism
MH  - Carcinoembryonic Antigen/metabolism
MH  - Cell Cycle Proteins/metabolism
MH  - Chemotherapy, Adjuvant
MH  - Diagnostic Tests, Routine/*methods
MH  - Disease-Free Survival
MH  - Female
MH  - GPI-Linked Proteins/metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Intracellular Signaling Peptides and Proteins/metabolism
MH  - Large Neutral Amino Acid-Transporter 1/metabolism
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Neoplasm Recurrence, Local
MH  - Prognosis
MH  - Receptors, Estrogen/metabolism
MH  - Reproducibility of Results
MH  - Risk Assessment/methods
MH  - Risk Factors
MH  - Sensitivity and Specificity
MH  - Tamoxifen/therapeutic use
MH  - Tumor Suppressor Protein p53/metabolism
PMC - PMC2949634
EDAT- 2010/07/10 06:00
MHDA- 2011/03/02 06:00
CRDT- 2010/07/10 06:00
PHST- 2010/03/09 00:00 [received]
PHST- 2010/03/28 00:00 [revised]
PHST- 2010/07/08 00:00 [accepted]
PHST- 2010/07/10 06:00 [entrez]
PHST- 2010/07/10 06:00 [pubmed]
PHST- 2011/03/02 06:00 [medline]
AID - bcr2604 [pii]
AID - 10.1186/bcr2604 [doi]
PST - ppublish
SO  - Breast Cancer Res. 2010;12(4):R47. doi: 10.1186/bcr2604. Epub 2010 Jul 8.


PMID- 20615219
OWN - NLM
STAT- MEDLINE
DCOM- 20110613
LR  - 20211020
IS  - 1747-5341 (Electronic)
IS  - 1747-5341 (Linking)
VI  - 5
DP  - 2010 Jul 8
TI  - Pain control in the African context: the Ugandan introduction of affordable
      morphine to relieve suffering at the end of life.
PG  - 10
LID - 10.1186/1747-5341-5-10 [doi]
AB  - Dr Anne Merriman is the founder of Hospice Africa and Hospice Africa Uganda. She 
      is presently Director of Policy and International Programmes. Here she tells the 
      story of how HAU was founded. Dr Richard Harding is an academic researcher
      working on palliative care in Sub-Saharan Africa. This paper described Dr
      Merriman's experience in pioneering palliative care provision. In particular it
      examines the steps to achieving wider availability of opioids for pain management
      for those with far advanced disease. Hospice Africa Uganda has been a model
      facility in achieving high quality clinical care embedded in a strategy of
      advocacy and education, using a multifaceted approach that has addressed
      logistical, policy and legislative barriers. Until 1990 control of severe pain in
      Sub-Saharan Africa was non-existent except in Zimbabwe and S Africa. Oral
      affordable morphine was brought to Kenya through Nairobi Hospice that year, and
      to Uganda through Hospice Africa Uganda in 1993. This paper offers an example of 
      a highly effective and cost efficient model of care that has transformed the
      ability to humanely manage the problems of those with terminal illness, and to
      offer a culturally appropriate "good death". Thus it is now possible to complete 
      the ethical circle of care in resource poor circumstances.
FAU - Merriman, Anne
AU  - Merriman A
AD  - Department of Palliative Care, Policy & Rehabilitation, Cicely Saunders
      Institute, King's College, London, UK.
FAU - Harding, Richard
AU  - Harding R
LA  - eng
PT  - Editorial
PT  - Historical Article
DEP - 20100708
PL  - England
TA  - Philos Ethics Humanit Med
JT  - Philosophy, ethics, and humanities in medicine : PEHM
JID - 101258058
RN  - 0 (Analgesics, Opioid)
RN  - 76I7G6D29C (Morphine)
SB  - IM
MH  - Analgesics, Opioid/administration & dosage/adverse effects/*therapeutic use
MH  - Health Services Accessibility
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Home Care Services
MH  - Hospice Care/history/*methods
MH  - Morphine/administration & dosage/adverse effects/*therapeutic use
MH  - Pain/*drug therapy
MH  - Pain Measurement
MH  - Stress, Psychological/*drug therapy
MH  - Terminal Care
MH  - Uganda
PMC - PMC2914675
EDAT- 2010/07/10 06:00
MHDA- 2011/06/15 06:00
CRDT- 2010/07/10 06:00
PHST- 2008/11/12 00:00 [received]
PHST- 2010/07/08 00:00 [accepted]
PHST- 2010/07/10 06:00 [entrez]
PHST- 2010/07/10 06:00 [pubmed]
PHST- 2011/06/15 06:00 [medline]
AID - 1747-5341-5-10 [pii]
AID - 10.1186/1747-5341-5-10 [doi]
PST - epublish
SO  - Philos Ethics Humanit Med. 2010 Jul 8;5:10. doi: 10.1186/1747-5341-5-10.


PMID- 20614662
OWN - NLM
STAT- MEDLINE
DCOM- 20100820
LR  - 20100709
IS  - 1320-3185 (Print)
IS  - 1320-3185 (Linking)
VI  - 17
IP  - 11
DP  - 2010 Jun
TI  - Ethics and ectogenesis.
PG  - 33
FAU - Johnstone, Megan-Jane
AU  - Johnstone MJ
AD  - The School of Nursing and Midwifery at Deakin University, Victoria.
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Aust Nurs J
JT  - Australian nursing journal (July 1993)
JID - 9317904
MH  - Dissent and Disputes
MH  - Ectogenesis/*ethics
MH  - Ethical Analysis
MH  - *Ethics, Nursing
MH  - Humans
MH  - Technology Assessment, Biomedical
EDAT- 2010/07/10 06:00
MHDA- 2010/08/21 06:00
CRDT- 2010/07/10 06:00
PHST- 2010/07/10 06:00 [entrez]
PHST- 2010/07/10 06:00 [pubmed]
PHST- 2010/08/21 06:00 [medline]
PST - ppublish
SO  - Aust Nurs J. 2010 Jun;17(11):33.


PMID- 20614380
OWN - NLM
STAT- MEDLINE
DCOM- 20101026
LR  - 20100708
IS  - 1532-8015 (Electronic)
IS  - 1040-1334 (Linking)
VI  - 22
IP  - 2
DP  - 2010 Apr
TI  - A novel advance directives course provides a transformative learning experience
      for medical students.
PG  - 137-41
LID - 10.1080/10401331003656678 [doi]
AB  - BACKGROUND: Inadequate physician training may be a barrier to physician-patient
      discussions of advance directives (ADs). DESCRIPTION: The purpose of this study
      was to determine the effects of an ADs course, which includes completing a
      directive, on medical students' perceived knowledge of and preparedness for
      discussing ADs with patients. All 4th-year medical students completed a 10-hr
      bioethics course comprising interactive lecture and small-group discussion
      formats. Curriculum content included ethical and legal aspects of ADs. An 8-item 
      survey with free-text entry was administered 1 month after course completion.
      Internal consistency reliability of survey scores was determined. Two authors
      independently coded the free-text comments and reached consensus on underlying
      themes. EVALUATION: Of the 89 students who completed the survey (response rate
      80%), 87 (98%) felt more knowledgeable and 88 (99%) better equipped to counsel
      patients about ADs. Forty-two (47%) reported they had counseled others to
      complete ADs during the month after the course. Internal consistency reliability 
      of survey scores was very good (Cronbach's alpha =.78). Dominant themes of
      responses to the question, "What was the most eye opening, troubling, or
      difficult aspect about filling out your advance directive?" included difficulties
      articulating wishes, legal language, selecting a surrogate, and facing mortality.
      CONCLUSIONS: These findings suggest an ADs course that includes completing a
      directive enhances medical students' empathy for and preparedness to discuss ADs 
      with patients.
FAU - Mueller, Paul S
AU  - Mueller PS
AD  - Division of General Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905,
      USA. mueller.pauls@mayo.edu
FAU - Litin, Scott C
AU  - Litin SC
FAU - Hook, C Christopher
AU  - Hook CC
FAU - Creagan, Edward T
AU  - Creagan ET
FAU - Cha, Stephen S
AU  - Cha SS
FAU - Beckman, Thomas J
AU  - Beckman TJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Teach Learn Med
JT  - Teaching and learning in medicine
JID - 8910884
SB  - IM
MH  - Adult
MH  - *Advance Directives
MH  - *Attitude of Health Personnel
MH  - Clinical Competence
MH  - Curriculum
MH  - Education, Medical, Undergraduate/*organization & administration
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Male
MH  - Patient Education as Topic
MH  - *Professional-Patient Relations
MH  - Students, Medical/*statistics & numerical data
MH  - Young Adult
EDAT- 2010/07/09 06:00
MHDA- 2010/10/27 06:00
CRDT- 2010/07/09 06:00
PHST- 2010/07/09 06:00 [entrez]
PHST- 2010/07/09 06:00 [pubmed]
PHST- 2010/10/27 06:00 [medline]
AID - 920535782 [pii]
AID - 10.1080/10401331003656678 [doi]
PST - ppublish
SO  - Teach Learn Med. 2010 Apr;22(2):137-41. doi: 10.1080/10401331003656678.


PMID- 20613535
OWN - NLM
STAT- MEDLINE
DCOM- 20110621
LR  - 20100812
IS  - 1751-4266 (Electronic)
IS  - 1751-4258 (Linking)
VI  - 4
IP  - 3
DP  - 2010 Sep
TI  - Stand by me: a volunteer's reflection on working on an academic palliative care
      unit in Germany.
PG  - 174-7
LID - 10.1097/SPC.0b013e32833c6ceb [doi]
AB  - PURPOSE OF REVIEW: To relate personal experience and reflections on the tasks and
      role of a volunteer in an academic palliative care unit into the context of the
      English publications of 2009. We took a snapshot of the most recent publications 
      as a way of placing the rather unique experiences of this German volunteer in an 
      international context. RECENT FINDINGS: Five recent studies were found discussing
      the importance of volunteers in an interdisciplinary context, but mainly focusing
      on the volunteer's role in the community, interacting with terminally ill
      patients and their caregivers. Furthermore, aspects of ethical issues, reasons
      for starting and continuing to volunteer for hospice and the role of male
      volunteers were evaluated in these studies. SUMMARY: The studies feature on the
      one hand the positive recognition of volunteers, for example, two studies
      revealed a significant interest by the respondents of having volunteers if they
      were dying. Also, these articles focused on family carers, who voted for the
      service of hospice/palliative care volunteers; on the other hand, efforts have to
      be made to improve the recruitment of volunteers especially if it comes to male
      support. A further study, reporting on ethical issues, indicates that little is
      known about these issues when it comes to a volunteer's interaction with a
      patient in difficult situations, how these are to be managed. These studies give 
      us valuable clues on how and where to make continuous improvements.
FAU - Boddeker, Andrea
AU  - Boddeker A
AD  - Department of Palliative Medicine, University Hospital Cologne, Cologne, Germany.
      andrea.boeddeker@uk-koeln.de
FAU - Smeding, Ruthmarijke
AU  - Smeding R
FAU - Voltz, Raymond
AU  - Voltz R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Curr Opin Support Palliat Care
JT  - Current opinion in supportive and palliative care
JID - 101297402
SB  - IM
MH  - Academic Medical Centers/*organization & administration
MH  - Caregivers/*psychology
MH  - Ethics, Medical
MH  - Germany
MH  - Hospice Care/organization & administration
MH  - Hospital Volunteers/*organization & administration
MH  - Humans
MH  - Male
MH  - Narration
MH  - Palliative Care/*organization & administration
MH  - Patient Care Team/*organization & administration
MH  - Quality of Life/*psychology
MH  - Religion
EDAT- 2010/07/09 06:00
MHDA- 2011/06/22 06:00
CRDT- 2010/07/09 06:00
PHST- 2010/07/09 06:00 [entrez]
PHST- 2010/07/09 06:00 [pubmed]
PHST- 2011/06/22 06:00 [medline]
AID - 10.1097/SPC.0b013e32833c6ceb [doi]
PST - ppublish
SO  - Curr Opin Support Palliat Care. 2010 Sep;4(3):174-7. doi:
      10.1097/SPC.0b013e32833c6ceb.


PMID- 20610585
OWN - NLM
STAT- MEDLINE
DCOM- 20101104
LR  - 20100708
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 4
DP  - 2010 Jul
TI  - Case study. Nursing ethics of treatment refusal by patients in Japan.
PG  - 523-6
LID - 10.1177/0969733010367765 [doi]
FAU - Edwards, Steven
AU  - Edwards S
FAU - McCarthy, Joan
AU  - McCarthy J
FAU - Konishi, Emiko
AU  - Konishi E
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Aged, 80 and over
MH  - Anemia/diagnosis/*nursing
MH  - Female
MH  - Gastroscopy/*nursing
MH  - Humans
MH  - Japan
MH  - Nurse-Patient Relations/*ethics
MH  - Peptic Ulcer Hemorrhage/diagnosis/*nursing
MH  - Treatment Refusal/*ethics
EDAT- 2010/07/09 06:00
MHDA- 2010/11/05 06:00
CRDT- 2010/07/09 06:00
PHST- 2010/07/09 06:00 [entrez]
PHST- 2010/07/09 06:00 [pubmed]
PHST- 2010/11/05 06:00 [medline]
AID - 17/4/523 [pii]
AID - 10.1177/0969733010367765 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 Jul;17(4):523-6. doi: 10.1177/0969733010367765.


PMID- 20610584
OWN - NLM
STAT- MEDLINE
DCOM- 20101104
LR  - 20151119
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 4
DP  - 2010 Jul
TI  - Bioethics education for practicing nurses in Taiwan: Confucian-Western clash.
PG  - 511-21
LID - 10.1177/0969733010364585 [doi]
AB  - To understand the gaps between current bioethics education and the requirements
      of practicing nurses, a semistructured questionnaire was used to invite the
      directors of nursing departments at all 82 teaching hospitals in Taiwan to
      participate in this survey. The response rate was 64.6%. Through content analysis
      we obtained information about previous bioethical training, required themes and
      content, recommended teaching strategies, and difficulties with education and its
      application. The results suggest that Taiwanese nursing personnel need to be
      instilled with both self-cultivation of morality and mental cultivation to
      acquire nursing virtues and the right attitudes toward bioethical issues. Good
      communication skills to prevent damage to the harmonious relationships between
      patients, their families and medical team members, policies that support the
      provision of systematic formal knowledge of ethics, small group training, and
      clarification of values were also shown to be important in bioethics education.
FAU - Yang, Wan-Ping
AU  - Yang WP
AD  - National Cheng-Kung University, Taiwan.
FAU - Chen, Ching-Huey
AU  - Chen CH
FAU - Chao, Co-Shi Chantal
AU  - Chao CS
FAU - Lai, Wei-Shu
AU  - Lai WS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Bioethics/*education
MH  - *Confucianism
MH  - Cross-Cultural Comparison
MH  - Health Care Surveys
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - *Inservice Training
MH  - Morals
MH  - Nursing Staff, Hospital/*education/*ethics
MH  - Qualitative Research
MH  - Social Values
MH  - Surveys and Questionnaires
MH  - Taiwan
MH  - Teaching/methods
MH  - *Western World
EDAT- 2010/07/09 06:00
MHDA- 2010/11/05 06:00
CRDT- 2010/07/09 06:00
PHST- 2010/07/09 06:00 [entrez]
PHST- 2010/07/09 06:00 [pubmed]
PHST- 2010/11/05 06:00 [medline]
AID - 17/4/511 [pii]
AID - 10.1177/0969733010364585 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 Jul;17(4):511-21. doi: 10.1177/0969733010364585.


PMID- 20610583
OWN - NLM
STAT- MEDLINE
DCOM- 20101104
LR  - 20100708
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 4
DP  - 2010 Jul
TI  - Nurses' perceptions of ethical issues related to patients' rights law.
PG  - 501-10
LID - 10.1177/0969733010368199 [doi]
AB  - August 2006 marked the 10th anniversary of landmark legislation when Israel's
      parliament passed the unique Patient's Rights Law. This law underscores the
      importance of medical ethics in Israeli society. During a seminar at the Shaare
      Zedek School of Nursing, third-year students performed a qualitative research
      study investigating ethical issues arising in the field of nursing, and how
      nursing staff dealt with these issues in relation to the law. The research was
      conducted using semistructured questionnaires. The results showed that the staff 
      participants knew the law, but did not differentiate between legal and ethical
      problems. The establishment of a framework for dealing with these issues would
      help to promote professional ethics, encourage broad-based agreements related to 
      ethical decisions, reduce ethical conflict, and increase implementation of the
      law on patients' rights.
FAU - Yakov, Gila
AU  - Yakov G
AD  - University of Haifa, Emek Yizreel College & Shaare Zedek School of Nursing,
      Jerusalem, 91031, Israel.
FAU - Shilo, Yehudit
AU  - Shilo Y
FAU - Shor, Tzippy
AU  - Shor T
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Confidentiality/ethics/legislation & jurisprudence
MH  - Disclosure/ethics/legislation & jurisprudence
MH  - *Ethics, Nursing/education
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Informed Consent/ethics/legislation & jurisprudence
MH  - Israel
MH  - Patient Rights/*ethics/*legislation & jurisprudence
EDAT- 2010/07/09 06:00
MHDA- 2010/11/05 06:00
CRDT- 2010/07/09 06:00
PHST- 2010/07/09 06:00 [entrez]
PHST- 2010/07/09 06:00 [pubmed]
PHST- 2010/11/05 06:00 [medline]
AID - 17/4/501 [pii]
AID - 10.1177/0969733010368199 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 Jul;17(4):501-10. doi: 10.1177/0969733010368199.


PMID- 20610581
OWN - NLM
STAT- MEDLINE
DCOM- 20101104
LR  - 20100708
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 4
DP  - 2010 Jul
TI  - Internal or external whistleblowing: nurses' willingness to report wrongdoing.
PG  - 483-90
LID - 10.1177/0969733010364898 [doi]
AB  - In Israel, whistleblowing in the nursing profession has been largely ignored.
      This topic is neither part of the professional-ethical discourse nor a subject
      for research. Focusing on the divide between internal and external
      whistleblowing, this article presents a study that explores nurses' willingness
      to disclose an act that could jeopardize the rights or safety of patients.
      Internal disclosure entails reporting wrongdoing to an authority within the
      organization. External disclosure involves reporting the offense to an outside
      agency, such as a professional organization or the press. The study's findings
      indicate that the nurse respondents viewed both the harmful misconduct of a
      colleague and that of a manager as being very serious. In such dilemmas the
      nurses reported a desire to correct the wrongdoing and a concomitant willingness 
      to act. They were, however, much more likely to whistleblow internally rather
      than externally. This study revealed a pattern of nurses' progressive retraction 
      as the circle of disclosure widened.
FAU - Mansbach, Abraham
AU  - Mansbach A
AD  - Ben Gurion University, Beer-Sheva 84105, Israel. mansbach@bgu.ac.il
FAU - Bachner, Yaacov G
AU  - Bachner YG
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - *Community-Institutional Relations
MH  - *Ethics, Nursing
MH  - Female
MH  - Humans
MH  - Israel
MH  - Male
MH  - Middle Aged
MH  - Patient Advocacy/*ethics
MH  - Personnel Loyalty
MH  - Professional Misconduct
MH  - Whistleblowing/*ethics
EDAT- 2010/07/09 06:00
MHDA- 2010/11/05 06:00
CRDT- 2010/07/09 06:00
PHST- 2010/07/09 06:00 [entrez]
PHST- 2010/07/09 06:00 [pubmed]
PHST- 2010/11/05 06:00 [medline]
AID - 17/4/483 [pii]
AID - 10.1177/0969733010364898 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 Jul;17(4):483-90. doi: 10.1177/0969733010364898.


PMID- 20610580
OWN - NLM
STAT- MEDLINE
DCOM- 20101104
LR  - 20220310
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 4
DP  - 2010 Jul
TI  - Ethical problems in nursing management: the role of codes of ethics.
PG  - 469-82
LID - 10.1177/0969733010364896 [doi]
AB  - The aim of this study was to identify the ethical problems that nurse managers
      encounter in their work and the role of codes of ethics in the solutions to these
      difficulties. The data were collected using a structured questionnaire and
      analysed statistically. The target sample included all nurse managers in 21
      specialized health care or primary health care organizations in two hospital
      districts in Finland (N = 501; response rate 41%). The most common ethical
      problems concerned resource allocation as well as providing and developing high
      quality care. This was the case in different managerial positions as well as in
      types of organization. Professional codes of ethics were used more often for
      problems related to patients' care compared with issues of resource allocation.
      Nurse managers at middle or strategic management levels used codes of ethics more
      often than those in charge of a ward. More research is required to investigate
      ethical decision making in nursing management, especially with regard to problem 
      solving. In addition, new guidelines and continuing education in ethics are
      important for management personnel.
FAU - Aitamaa, Elina
AU  - Aitamaa E
AD  - University of Turku & Satakunta Hospital District, Sairaalantie 3, FI-28500 Pori,
      Finland. emaita@utu.fi
FAU - Leino-Kilpi, Helena
AU  - Leino-Kilpi H
FAU - Puukka, Pauli
AU  - Puukka P
FAU - Suhonen, Riitta
AU  - Suhonen R
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Adult
MH  - *Codes of Ethics
MH  - Decision Making/*ethics
MH  - Female
MH  - Finland
MH  - Health Care Rationing/ethics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nurse Administrators/*ethics
MH  - Nursing Care/ethics
MH  - Nursing, Supervisory/*ethics
MH  - Personnel Administration, Hospital/ethics
MH  - Practice Patterns, Nurses'/*ethics
MH  - Quality of Health Care
EDAT- 2010/07/09 06:00
MHDA- 2010/11/05 06:00
CRDT- 2010/07/09 06:00
PHST- 2010/07/09 06:00 [entrez]
PHST- 2010/07/09 06:00 [pubmed]
PHST- 2010/11/05 06:00 [medline]
AID - 17/4/469 [pii]
AID - 10.1177/0969733010364896 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 Jul;17(4):469-82. doi: 10.1177/0969733010364896.


PMID- 20610579
OWN - NLM
STAT- MEDLINE
DCOM- 20101104
LR  - 20100708
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 4
DP  - 2010 Jul
TI  - Ethical practice in end-of-life care in Japan.
PG  - 457-68
LID - 10.1177/0969733010364584 [doi]
AB  - Nurses are obliged to provide quality nursing care that meets the ethical
      standards of their profession. However, clear descriptions of ethical practice
      are largely missing in the literature. Qualitative research using a
      phenomenological approach was conducted to explicate ethical nursing practice in 
      Japanese end-of-life care settings and to discover how ethical practices unfold
      in clinical situations. Two paradigm cases and contrasting narratives of
      memorable end-of-life care from 32 Japanese nurses were used to reveal four
      levels of ethical practice: ethical, distressed, uncertain, and unethical. Having
      the ability to actualize, justify, and recognize what is the good and/or right
      differentiated between these levels of ethical practice, empirical descriptions
      of which are given, followed by discussion of how nurses gain the skilled
      knowledge necessary for ethical practice.
FAU - Izumi, Shigeko
AU  - Izumi S
AD  - Washington State University, WA 99210-1495, USA. seiko.izumi@wsu.edu
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Narration
MH  - Nurse-Patient Relations/*ethics
MH  - Nursing Care/*ethics
MH  - Nursing Staff, Hospital/ethics
MH  - Terminal Care/*ethics
EDAT- 2010/07/09 06:00
MHDA- 2010/11/05 06:00
CRDT- 2010/07/09 06:00
PHST- 2010/07/09 06:00 [entrez]
PHST- 2010/07/09 06:00 [pubmed]
PHST- 2010/11/05 06:00 [medline]
AID - 17/4/457 [pii]
AID - 10.1177/0969733010364584 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 Jul;17(4):457-68. doi: 10.1177/0969733010364584.


PMID- 20610577
OWN - NLM
STAT- MEDLINE
DCOM- 20101104
LR  - 20161125
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 4
DP  - 2010 Jul
TI  - Information disclosure to family caregivers: applying Thiroux's framework.
PG  - 435-44
LID - 10.1177/0969733010364892 [doi]
AB  - In the UK, community care has led to more complex relationships for mental health
      nurses. They need to respect the rights of service users to confidentiality while
      also respecting the rights of family caregivers to information that directly
      affects them. An unsatisfactory situation has arisen in which utilitarian and
      legally driven motives have seen family caregivers' interests become subsidiary
      to those of service users and providers. An ethical case is made for sharing
      information with family caregivers, even against the wishes of service users.
      Through the use of a conceptual framework based on elements proposed by Thiroux -
      value of life, goodness or rightness, justice or fairness, truth-telling or
      honesty, and individual freedom - the article concludes that there is an ethical 
      argument for sharing some information with family caregivers and that nurses
      should respect caregivers' rights through their actions. Nurses' actions are a
      commitment to seeking what is 'good' by making judgements based on what matters. 
      It is argued that people and their relationships matter more than strict
      adherence to laws and codes.
FAU - Rowe, John
AU  - Rowe J
AD  - Open University, Horlock Building, Walton Hall, Milton Keynes, Bucks MK7 6AA, UK.
      j.m.rowe@open.ac.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Beneficence
MH  - *Caregivers
MH  - Confidentiality/*ethics/legislation & jurisprudence
MH  - Disclosure/*ethics/legislation & jurisprudence
MH  - Ethical Theory
MH  - Freedom
MH  - Humans
MH  - Professional-Family Relations/*ethics
MH  - Psychiatric Nursing/*ethics
MH  - Social Justice
MH  - United Kingdom
MH  - Value of Life
EDAT- 2010/07/09 06:00
MHDA- 2010/11/05 06:00
CRDT- 2010/07/09 06:00
PHST- 2010/07/09 06:00 [entrez]
PHST- 2010/07/09 06:00 [pubmed]
PHST- 2010/11/05 06:00 [medline]
AID - 17/4/435 [pii]
AID - 10.1177/0969733010364892 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 Jul;17(4):435-44. doi: 10.1177/0969733010364892.


PMID- 20610574
OWN - NLM
STAT- MEDLINE
DCOM- 20101104
LR  - 20161125
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 4
DP  - 2010 Jul
TI  - Editorial. Ethical responses to unethical practices.
PG  - 419-20
LID - 10.1177/0969733010368908 [doi]
FAU - Gallagher, Ann
AU  - Gallagher A
LA  - eng
PT  - Editorial
PT  - Introductory Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - *Ethics, Nursing
MH  - Humans
MH  - United Kingdom
EDAT- 2010/07/09 06:00
MHDA- 2010/11/05 06:00
CRDT- 2010/07/09 06:00
PHST- 2010/07/09 06:00 [entrez]
PHST- 2010/07/09 06:00 [pubmed]
PHST- 2010/11/05 06:00 [medline]
AID - 17/4/419 [pii]
AID - 10.1177/0969733010368908 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 Jul;17(4):419-20. doi: 10.1177/0969733010368908.


PMID- 20610465
OWN - NLM
STAT- MEDLINE
DCOM- 20101206
LR  - 20211020
IS  - 1745-9206 (Electronic)
IS  - 1742-3953 (Linking)
VI  - 6
IP  - 3
DP  - 2010 Sep
TI  - Everyday ethics and help-seeking in early rheumatoid arthritis.
PG  - 171-82
LID - 10.1177/1742395309351963 [doi]
AB  - BACKGROUND: Sociological understandings of chronic illness have revealed tensions
      and complexities around help-seeking. Although ethics underpins healthcare, its
      application in the area of chronic illness is limited. Here we apply an ethical
      framework to interview accounts and identify ethical challenges in the early
      rheumatoid arthritis (RA) experience. METHODS: In-depth interviews were conducted
      with eight participants who had been diagnosed with RA in the 12 months prior to 
      recruitment. Applying the concepts of autonomous decision-making and procedural
      justice highlighted ethical concerns which arose throughout the help-seeking
      process. Analysis was based on the constant-comparison approach. RESULTS:
      Individuals described decision-making, illness actions and the medical encounter.
      The process was complicated by inadequate knowledge about symptoms, common-sense 
      understandings about the GP appointment, difficulties concerning access to
      specialists, and patient-practitioner interactions. Autonomous decision-making
      and procedural justice were compromised. The accounts revealed contradictions
      between the policy ideals of active self-management, patient-centred care and
      shared decision-making, and the everyday experiences of individuals. CONCLUSIONS:
      For ethical healthcare there is a need for: public knowledge about early RA
      symptoms; more effective patient-practitioner communication; and increased
      support during the wait between primary and secondary care. Healthcare facilities
      and the government may consider different models to deliver services to people
      requiring rheumatology consults.
FAU - Townsend, A
AU  - Townsend A
AD  - CIHR Ethics of Health Research Health and Training Program, The W. Maurice Young 
      Centre for Applied Ethics, University of British Columbia, 235-6356 Agricultural 
      Road, Klinck Building, Vancouver, British Columbia V6T 1Z2, Canada.
      atownsen@interchange.ubc.ca
FAU - Adam, P
AU  - Adam P
FAU - Cox, S M
AU  - Cox SM
FAU - Li, L C
AU  - Li LC
LA  - eng
GR  - 84434-1/CAPMC/ CIHR/Canada
PT  - Journal Article
DEP - 20100707
PL  - United States
TA  - Chronic Illn
JT  - Chronic illness
JID - 101253019
SB  - IM
MH  - Arthritis, Rheumatoid/*psychology/therapy
MH  - Attitude to Health
MH  - Decision Making
MH  - Early Diagnosis
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Patient Acceptance of Health Care/*ethnology/*psychology
MH  - Patient Selection/*ethics
MH  - Personal Autonomy
MH  - Surveys and Questionnaires
PMC - PMC5760220
MID - CAMS6639
EDAT- 2010/07/09 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/07/09 06:00
PHST- 2010/07/09 06:00 [entrez]
PHST- 2010/07/09 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 1742395309351963 [pii]
AID - 10.1177/1742395309351963 [doi]
PST - ppublish
SO  - Chronic Illn. 2010 Sep;6(3):171-82. doi: 10.1177/1742395309351963. Epub 2010 Jul 
      7.


PMID- 20610312
OWN - NLM
STAT- MEDLINE
DCOM- 20100928
LR  - 20220331
IS  - 1532-2750 (Electronic)
IS  - 1098-612X (Linking)
VI  - 12
IP  - 7
DP  - 2010 Jul
TI  - Reproduction control in cats: new developments in non-surgical methods.
PG  - 539-46
LID - 10.1016/j.jfms.2010.05.005 [doi]
AB  - PRACTICAL RELEVANCE: Reproduction control is an area of feline medicine that is
      assuming increasing importance in companion animal practice. Signs of oestrus
      such as increased vocalisation, rolling on the ground and a very short
      interoestrous interval may negatively influence the relationship between cat and 
      owner, and prompt the owner to seek a method of reproduction control. In breeding
      catteries, control of reproduction may be needed as part of a planned breeding
      programme. CLINICAL CHALLENGES: Surgical contraception is not always the owner's 
      wish - especially when a cat may be intended for future breeding. Besides,
      ethical principles and animal welfare legislation in an increasing number of
      countries are imposing restrictions on this 'classical approach' to reproduction 
      control. Progestins are routinely used as non-surgical alternatives in cases
      where fertility is to be preserved, but the associated risks of uterine disease, 
      mammary tumours, fibroadenomatosis or diabetes mellitus have to be taken into
      account - especially in predisposed animals. Modern, effective pharmacological
      alternatives are available for managing oestrous suppression and unwanted
      pregnancy. Detailed knowledge of the physiology of the oestrous cycle in the cat 
      is necessary to ensure that the appropriate treatment is chosen for the
      individual animal and its owner. AUDIENCE: This article presents an update for
      small animal practitioners on these alternative methods; specifically, the use of
      slow-release GnRH agonists or melatonin implants for hormonal contraception, and 
      the antiprogestin aglepristone for pregnancy termination. EVIDENCE BASE: Several 
      studies have documented the mode of action and risk of side effects of the
      traditional alternative to surgical castration - treatment with progestins.
      Evidence underpinning the safety and efficacy of GnRH agonists and melatonin
      implants for suppression of fertility in queens and toms is reviewed.
CI  - Copyright 2010 ISFM and AAFP. Published by Elsevier Ltd. All rights reserved.
FAU - Goericke-Pesch, Sandra
AU  - Goericke-Pesch S
AD  - Clinic for Obstetrics, Gynecology and Andrology of Large and Small Animals,
      Justus-Liebig University, Frankfurter Strasse 106, 35392 Giessen, Germany.
      Sandra.Pesch@vetmed.uni-giessen.de
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Feline Med Surg
JT  - Journal of feline medicine and surgery
JID - 100897329
SB  - IM
MH  - Animals
MH  - Cats/*physiology
MH  - Contraception/methods/*veterinary
MH  - Female
MH  - Male
MH  - Pregnancy
MH  - Reproduction/*physiology
RF  - 33
EDAT- 2010/07/09 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/07/09 06:00
PHST- 2010/07/09 06:00 [entrez]
PHST- 2010/07/09 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - S1098-612X(10)00158-0 [pii]
AID - 10.1016/j.jfms.2010.05.005 [doi]
PST - ppublish
SO  - J Feline Med Surg. 2010 Jul;12(7):539-46. doi: 10.1016/j.jfms.2010.05.005.


PMID- 20609820
OWN - NLM
STAT- MEDLINE
DCOM- 20100803
LR  - 20141120
IS  - 1552-6259 (Electronic)
IS  - 0003-4975 (Linking)
VI  - 90
IP  - 1
DP  - 2010 Jul
TI  - Early experience with combined use of two plant-based hemostatic agents.
PG  - 327-8
LID - 10.1016/j.athoracsur.2009.08.067 [doi]
AB  - Bleeding from anastomoses, which is more effectively controlled with topical
      hemostatic agents than with sutures, has been one of the major problems in
      cardiovascular surgery. We describe a novel hemostatic technique using
      microporous polysaccharide hemosphere (Arista; Medafor Inc, Minneapolis, MN) in
      conjunction with a patch of oxidized regenerated cellulose (Nu-Knit; Ethicon,
      Johnson & Johnson, Somerville, NJ). Both of them are plant-based products and
      eliminate the risk of animal-borne or human-borne contaminants and have
      bactericidal advantages.
CI  - Copyright 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All
      rights reserved.
FAU - Matsushita, Tsutomu
AU  - Matsushita T
AD  - Department of Cardiovascular Surgery, Maizuru Mutual Hospital, Maizuru, Kyoto,
      Japan. atmatsu@tokyonet.com.au
FAU - Masuda, Shinsuke
AU  - Masuda S
FAU - Inoue, Tomoya
AU  - Inoue T
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Netherlands
TA  - Ann Thorac Surg
JT  - The Annals of thoracic surgery
JID - 15030100R
RN  - 0 (Cellulose, Oxidized)
RN  - 0 (Hemostatics)
RN  - 0 (Polysaccharides)
SB  - IM
MH  - Administration, Topical
MH  - Aged
MH  - Aortic Aneurysm, Thoracic/*surgery
MH  - Blood Loss, Surgical/*prevention & control
MH  - Blood Vessel Prosthesis Implantation
MH  - Cellulose, Oxidized/*administration & dosage
MH  - Drug Therapy, Combination
MH  - Hemostatics/*administration & dosage
MH  - Humans
MH  - Male
MH  - Polysaccharides/*administration & dosage
EDAT- 2010/07/09 06:00
MHDA- 2010/08/04 06:00
CRDT- 2010/07/09 06:00
PHST- 2009/07/30 00:00 [received]
PHST- 2009/08/24 00:00 [revised]
PHST- 2009/08/26 00:00 [accepted]
PHST- 2010/07/09 06:00 [entrez]
PHST- 2010/07/09 06:00 [pubmed]
PHST- 2010/08/04 06:00 [medline]
AID - S0003-4975(09)01781-0 [pii]
AID - 10.1016/j.athoracsur.2009.08.067 [doi]
PST - ppublish
SO  - Ann Thorac Surg. 2010 Jul;90(1):327-8. doi: 10.1016/j.athoracsur.2009.08.067.


PMID- 20609739
OWN - NLM
STAT- MEDLINE
DCOM- 20100803
LR  - 20211020
IS  - 1552-6259 (Electronic)
IS  - 0003-4975 (Linking)
VI  - 90
IP  - 1
DP  - 2010 Jul
TI  - Ethics in cardiothoracic surgery: a survey of surgeons' views.
PG  - 11-13.e1-4
LID - 10.1016/j.athoracsur.2010.03.061 [doi]
AB  - BACKGROUND: Cardiothoracic surgeons are frequently confronted with complex
      ethical issues. Educational efforts to help surgeons navigate such issues have
      been undertaken in recent years, but their effectiveness is uncertain. METHODS: A
      survey instrument exploring the effects of ethics educational sessions at annual 
      meetings and publications in cardiothoracic surgery journals was sent
      electronically to cardiothoracic surgeons who belong to The Society of Thoracic
      Surgeons and the American Association for Thoracic Surgery. RESULTS: Of 3,705
      surgeons, 578 responded (15.6%). The majority of respondents practice in an
      academic setting (55%), attended at least two of the last five Society annual
      meetings (66%), and at least one of the last five Association annual meetings
      (68%). A majority of respondents agreed that their own practices would be
      improved (69%) and that cardiothoracic surgeons in general would benefit (83%)
      from better understanding of ethical issues. Respondents also believed that
      demonstration of an adequate understanding of ethical issues should be part of
      both American Board of Thoracic Surgery certification and maintenance of
      certification processes (61% and 60%, respectively). Among respondents who
      attended ethics presentations at annual meetings, only 4% believed that the
      sessions did not improve their understanding of complex ethical issues, and only 
      10% believed that the sessions did not affect their surgical practices.
      CONCLUSIONS: The survey suggested that efforts toward ethics education for
      cardiothoracic surgeons might be both relevant and important; the results
      encourage continuation and further improvement of such efforts.
CI  - Copyright 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All
      rights reserved.
FAU - D'Amico, Thomas A
AU  - D'Amico TA
AD  - Division of Thoracic Surgery, Duke University Medical Center, Durham, North
      Carolina, USA.
FAU - McKneally, Martin F
AU  - McKneally MF
FAU - Sade, Robert M
AU  - Sade RM
LA  - eng
GR  - UL1 RR029882/RR/NCRR NIH HHS/United States
GR  - UL1 RR029882-03/RR/NCRR NIH HHS/United States
GR  - UL1RR029882/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Ann Thorac Surg
JT  - The Annals of thoracic surgery
JID - 15030100R
SB  - IM
MH  - Ethics, Clinical
MH  - Health Care Surveys
MH  - Humans
MH  - Thoracic Surgery/*ethics
PMC - PMC4481736
MID - NIHMS335043
EDAT- 2010/07/09 06:00
MHDA- 2010/08/04 06:00
CRDT- 2010/07/09 06:00
PHST- 2010/01/06 00:00 [received]
PHST- 2010/03/12 00:00 [revised]
PHST- 2010/03/16 00:00 [accepted]
PHST- 2010/07/09 06:00 [entrez]
PHST- 2010/07/09 06:00 [pubmed]
PHST- 2010/08/04 06:00 [medline]
AID - S0003-4975(10)00673-9 [pii]
AID - 10.1016/j.athoracsur.2010.03.061 [doi]
PST - ppublish
SO  - Ann Thorac Surg. 2010 Jul;90(1):11-13.e1-4. doi:
      10.1016/j.athoracsur.2010.03.061.


PMID- 20609718
OWN - NLM
STAT- MEDLINE
DCOM- 20100812
LR  - 20220318
IS  - 1879-1883 (Electronic)
IS  - 0002-9610 (Linking)
VI  - 199
IP  - 6
DP  - 2010 Jun
TI  - Evaluation of a new ultrasonic device in thyroid surgery: comparative randomized 
      study.
PG  - 736-40
LID - 10.1016/j.amjsurg.2009.04.003 [doi]
AB  - BACKGROUND: Conventional techniques for hemostasis during thyroidectomy rely on
      knot tying, clips, and electrocoagulation. Recently, the Harmonic FOCUS Shear
      (Ethicon Endo-Surgery, Inc, Cincinnati, OH) was developed for thyroidectomy.
      METHODS: Between December 2007 and March 2008, 62 consecutive patients (45 women,
      17 men; mean age 50.9 years) undergoing thyroidectomy were randomized into 2
      groups: group A, where the FOCUS was used, and group B, where electrocoagulation 
      and clamp-and-tie technique were used. RESULTS: The 2 groups were similar in
      terms of age, sex ratio, indication for surgery, and thyroid volume. Operative
      time was significantly shorter in group A. Significantly fewer clips and ties
      were used, and postoperative pain and suction balloon amount were also
      significantly lower in the FOCUS group. The only postoperative complication was a
      patient with transient hypocalcemia in group B. CONCLUSIONS: FOCUS is a reliable 
      and safe tool for thyroidectomy. Its utilization is associated with a shorter
      operative time, less blood loss, and less postoperative pain.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Miccoli, Paolo
AU  - Miccoli P
AD  - Department of Surgery, University of Pisa, Via, Rome 67 56100, Pisa, Italy.
FAU - Materazzi, Gabriele
AU  - Materazzi G
FAU - Miccoli, Mario
AU  - Miccoli M
FAU - Frustaci, Gianluca
AU  - Frustaci G
FAU - Fosso, Alessandra
AU  - Fosso A
FAU - Berti, Piero
AU  - Berti P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Am J Surg
JT  - American journal of surgery
JID - 0370473
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chi-Square Distribution
MH  - Electrocoagulation/instrumentation
MH  - Female
MH  - Hemostasis, Surgical/*instrumentation
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Statistics, Nonparametric
MH  - Thyroidectomy/*instrumentation
MH  - Treatment Outcome
MH  - Ultrasonic Therapy/*instrumentation
EDAT- 2010/07/09 06:00
MHDA- 2010/08/13 06:00
CRDT- 2010/07/09 06:00
PHST- 2009/01/24 00:00 [received]
PHST- 2009/04/05 00:00 [revised]
PHST- 2009/04/06 00:00 [accepted]
PHST- 2010/07/09 06:00 [entrez]
PHST- 2010/07/09 06:00 [pubmed]
PHST- 2010/08/13 06:00 [medline]
AID - S0002-9610(09)00299-2 [pii]
AID - 10.1016/j.amjsurg.2009.04.003 [doi]
PST - ppublish
SO  - Am J Surg. 2010 Jun;199(6):736-40. doi: 10.1016/j.amjsurg.2009.04.003.


PMID- 20609661
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20151119
IS  - 1879-1913 (Electronic)
IS  - 0002-9149 (Linking)
VI  - 106
IP  - 1
DP  - 2010 Jul 1
TI  - Legal risks of "curbside" consults.
PG  - 135-8
LID - 10.1016/j.amjcard.2010.02.024 [doi]
AB  - "Curbside" consults, in which physicians informally solicit one another's
      opinions, are an integral part of our medical culture and invaluable to the care 
      of our patients. Unfortunately, there is widespread uncertainty as to the degree 
      of legal risk they pose and growing concern in the risk management community that
      curbside consults should be limited in scope if not eliminated entirely. This
      places curbside consultants in a quandary, seemingly forced to choose among their
      ethical obligation to patients, their sense of duty to colleagues, and their own 
      legal well-being. The author evaluates the legal aspects of curbside consults,
      distinguishes them from clinical interactions with which they must not be
      confused, and then provides guidance for conducting curbside consults. In
      conclusion, curbside consults should occur as often as needed and to whatever
      degree is necessary for proper patient care.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Cotton, Victor R
AU  - Cotton VR
LA  - eng
PT  - Editorial
DEP - 20100513
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
SB  - IM
MH  - Humans
MH  - *Practice Patterns, Physicians'
MH  - *Referral and Consultation
EDAT- 2010/07/09 06:00
MHDA- 2010/09/16 06:00
CRDT- 2010/07/09 06:00
PHST- 2009/12/17 00:00 [received]
PHST- 2010/02/07 00:00 [revised]
PHST- 2010/02/07 00:00 [accepted]
PHST- 2010/07/09 06:00 [entrez]
PHST- 2010/07/09 06:00 [pubmed]
PHST- 2010/09/16 06:00 [medline]
AID - S0002-9149(10)00621-1 [pii]
AID - 10.1016/j.amjcard.2010.02.024 [doi]
PST - ppublish
SO  - Am J Cardiol. 2010 Jul 1;106(1):135-8. doi: 10.1016/j.amjcard.2010.02.024. Epub
      2010 May 13.


PMID- 20609508
OWN - NLM
STAT- MEDLINE
DCOM- 20100902
LR  - 20211028
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 71
IP  - 5
DP  - 2010 Sep
TI  - How the mass media report social statistics: a case study concerning research on 
      end-of-life decisions.
PG  - 861-8
LID - 10.1016/j.socscimed.2010.05.048 [doi]
AB  - The issue of whether it is right to be concerned about the accuracy with which
      mass media report social scientific research is explored through a detailed case 
      study of media reporting of two surveys of UK doctors' end-of-life
      decision-making. Data include press releases, emails and field notes taken during
      periods of media interest supplemented by a collection of print and broadcast
      media reports. The case study contributes to existing knowledge about the ways in
      which mass media establish, exaggerate and otherwise distort the meaning of
      statistical findings. Journalists ignored findings that did not fit into existing
      media interest in the 'assisted dying' story and were subject to pressure from
      interest groups concerned to promote their own interpretations and viewpoints.
      Rogue statistics mutated as they were set loose from their original research
      report context and were 'laundered' as they passed from one media report to
      another. Yet media accounts of the research, fuelling an already heated public
      debate about ethical issues in end-of-life care, arguably acted as a conduit for 
      introducing new considerations into this debate, such as the role played by
      sedation at the end of life, the extent to which euthanasia is practiced outside 
      the law, and the extent of medical opposition to the legalisation of assisted
      dying. The expectation that accuracy and comprehensiveness should be the sole
      criteria for judging journalists' reports is, finally, considered to be
      unrealistic and it is argued that social scientists need to understand and
      adapted to the conditions under which mass media reporting operates if they are
      to succeed in introducing the findings of social research into public debates.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Seale, Clive
AU  - Seale C
AD  - Queen Mary University of London, Centre for Health Sciences, 2 Newark Street,
      London E1 2AT, United Kingdom. c.seale@qmul.ac.uk
LA  - eng
GR  - 086034/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100619
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Attitude of Health Personnel
MH  - *Bibliometrics
MH  - Data Collection
MH  - Decision Making
MH  - Euthanasia
MH  - Humans
MH  - *Journalism, Medical/standards
MH  - *Mass Media
MH  - Social Sciences
MH  - Statistics as Topic
MH  - Suicide, Assisted/*statistics & numerical data
MH  - Terminal Care/ethics/*statistics & numerical data
MH  - United Kingdom
EDAT- 2010/07/09 06:00
MHDA- 2010/09/03 06:00
CRDT- 2010/07/09 06:00
PHST- 2010/03/05 00:00 [received]
PHST- 2010/05/21 00:00 [revised]
PHST- 2010/05/28 00:00 [accepted]
PHST- 2010/07/09 06:00 [entrez]
PHST- 2010/07/09 06:00 [pubmed]
PHST- 2010/09/03 06:00 [medline]
AID - S0277-9536(10)00468-5 [pii]
AID - 10.1016/j.socscimed.2010.05.048 [doi]
PST - ppublish
SO  - Soc Sci Med. 2010 Sep;71(5):861-8. doi: 10.1016/j.socscimed.2010.05.048. Epub
      2010 Jun 19.


PMID- 20609506
OWN - NLM
STAT- MEDLINE
DCOM- 20100831
LR  - 20220311
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 71
IP  - 4
DP  - 2010 Aug
TI  - Contemporary neuroscience in the media.
PG  - 725-33
LID - 10.1016/j.socscimed.2010.05.017 [doi]
AB  - Technological innovations in neuroscience have opened new windows to the
      understanding of brain function and the neuronal underpinnings of brain activity 
      in neuropsychiatric disorders and social behavior. Public interest and support
      for neuroscience research through initiatives like the Decade of the Brain
      project and increasingly diverse brain-related initiatives have created new
      interfaces between neuroscience and society. Against this backdrop of dynamic
      innovation, we set out to examine how different features of neuroscience are
      depicted in print media. We used the 'guided news' function of the LexisNexis
      Academic database with keyword searches to find news articles published between
      1995 and 2004 in major U.S. and U.K. English-language news sources. We performed 
      searches on headlines, lead paragraphs, and body terms to maximize search yields.
      All articles were coded for overall tone of coverage, details on reported
      studies, presence of ethical, legal, and social discussion as well as the
      emerging interpretations of neuroscience - in the form of neuro-essentialism,
      neuro-realism, and neuro-policy. We found that print media coverage of the use of
      neurotechnology for diagnosis or therapy in neuropsychiatric disorders was
      generally optimistic. We also found that, even within articles that were
      identified as research reports, many did not provide details about research
      studies. We also gained additional insights into the previously identified
      phenomena of neuro-essentialism, neuro-realism, and neuro-policy showing some
      profound impacts of neuroscience on personal identity and policy-making. Our
      results highlight the implications of transfer of neuroscience knowledge to
      society given the substantial and authoritative weight ascribed to neuroscience
      knowledge in defining who we are. We also discuss the impact of these findings on
      neuroscience and on the respective contributions of the social sciences and the
      biological sciences in contemporary psychiatry and mental health policy.
CI  - (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Racine, Eric
AU  - Racine E
AD  - Neuroethics Research Unit, Institut de recherches cliniques de Montreal, 110
      avenue des Pins Ouest, Montreal, Quebec H2W 1R7, Canada. eric.racine@ircm.qc.ca
FAU - Waldman, Sarah
AU  - Waldman S
FAU - Rosenberg, Jarett
AU  - Rosenberg J
FAU - Illes, Judy
AU  - Illes J
LA  - eng
GR  - R01 NS045831/NS/NINDS NIH HHS/United States
GR  - R01 NS045831-03/NS/NINDS NIH HHS/United States
GR  - CAPMC/ CIHR/Canada
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20100604
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - *Bibliometrics
MH  - Biomedical Technology
MH  - Brain/physiology/physiopathology
MH  - Diagnostic Imaging/methods
MH  - Electroencephalography
MH  - Humans
MH  - *Journalism, Medical
MH  - *Mass Media/statistics & numerical data
MH  - *Neurosciences
MH  - United Kingdom
MH  - United States
PMC - PMC2925284
MID - NIHMS221757
EDAT- 2010/07/09 06:00
MHDA- 2010/09/02 06:00
CRDT- 2010/07/09 06:00
PHST- 2009/03/25 00:00 [received]
PHST- 2010/04/28 00:00 [revised]
PHST- 2010/05/17 00:00 [accepted]
PHST- 2010/07/09 06:00 [entrez]
PHST- 2010/07/09 06:00 [pubmed]
PHST- 2010/09/02 06:00 [medline]
AID - S0277-9536(10)00416-8 [pii]
AID - 10.1016/j.socscimed.2010.05.017 [doi]
PST - ppublish
SO  - Soc Sci Med. 2010 Aug;71(4):725-33. doi: 10.1016/j.socscimed.2010.05.017. Epub
      2010 Jun 4.


PMID- 20609048
OWN - NLM
STAT- MEDLINE
DCOM- 20101102
LR  - 20100708
IS  - 1365-2834 (Electronic)
IS  - 0966-0429 (Linking)
VI  - 18
IP  - 4
DP  - 2010 May
TI  - The making of a nurse manager: the role of experiential learning in leadership
      development.
PG  - 440-7
LID - 10.1111/j.1365-2834.2010.01082.x [doi]
AB  - AIM: To articulate the experientially acquired knowledge, skill and ethics
      embedded in nurse manager practice and describe the ways in which they were
      developed. BACKGROUND: The role of the nurse manager is usually described in
      lists of competencies, talents and traits which fail to capture the
      experience-based judgment and practical knowledge in this pivotal organizational 
      role. METHOD: Using Benner's methodology of practice articulation, 32 nurse
      managers wrote and interpreted first person narratives of their practice. The
      experience level of the group ranged from new nurse managers to those with more
      than 10 years' role tenure. The seminars were facilitated by a seasoned nurse
      executive and nurse manager with expertise in narrative interpretation. RESULTS: 
      Interpretation of the paradigm case of one nurse manager suggests that complex
      leadership challenges can be a source of significant experiential learning for
      the individual and for the group. CONCLUSIONS; Articulating and reflecting on
      experiential learning elucidates the skilled knowledge and judgment embedded in
      nurse manager practice which cannot be accessed in any other way. IMPLICATIONS
      FOR NURSING MANAGEMENT: Articulating the practical knowledge which is necessary
      for effective nurse manager practice can hasten the development of role
      incumbents.
FAU - Cathcart, Eloise Balasco
AU  - Cathcart EB
AD  - Coordinator Graduate Program in Nursing Administration, New York University
      College of Nursing, New York, NY 10003, USA. eloise.cathcart@nyu.edu
FAU - Greenspan, Miriam
AU  - Greenspan M
FAU - Quin, Matthew
AU  - Quin M
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Nurs Manag
JT  - Journal of nursing management
JID - 9306050
MH  - Adult
MH  - Boston
MH  - Emergencies
MH  - Female
MH  - Hemofiltration/nursing
MH  - Humans
MH  - Intraoperative Complications/nursing/therapy
MH  - *Leadership
MH  - Male
MH  - Narration
MH  - *Nurse Administrators
MH  - Nurse's Role
MH  - Nursing Staff, Hospital/ethics/organization & administration
MH  - *Problem-Based Learning
MH  - *Professional Competence
EDAT- 2010/07/09 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/07/09 06:00
PHST- 2010/07/09 06:00 [entrez]
PHST- 2010/07/09 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - JNM1082 [pii]
AID - 10.1111/j.1365-2834.2010.01082.x [doi]
PST - ppublish
SO  - J Nurs Manag. 2010 May;18(4):440-7. doi: 10.1111/j.1365-2834.2010.01082.x.


PMID- 20609042
OWN - NLM
STAT- MEDLINE
DCOM- 20101102
LR  - 20220409
IS  - 1365-2834 (Electronic)
IS  - 0966-0429 (Linking)
VI  - 18
IP  - 4
DP  - 2010 May
TI  - Fear of childbirth: mothers' experiences of team-midwifery care - a follow-up
      study.
PG  - 383-90
LID - 10.1111/j.1365-2834.2010.01103.x [doi]
AB  - AIM: The aim of this study was to illuminate mothers' fear of childbirth and
      their experiences of the team-midwifery care model during pregnancy, childbirth
      and the postnatal period. BACKGROUND: Maternal anxiety and fear of childbirth
      lead to emotional suffering and affected women's well-being. A previous negative 
      experience of childbirth may result in postnatal depression or avoidance of
      future pregnancies. METHODS: This hermeneutic study comprised interviews with 13 
      women, which were audio-taped and transcribed verbatim, after which
      interpretative content analysis was performed. Ethical approval was granted.
      RESULTS: The findings revealed one main theme: The woman's right to ownership of 
      the pregnancy, childbirth and postnatal care as a means of maintaining dignity
      and three themes; Being aware of barriers and reasons for fear; Being prepared
      for childbirth and Being confirmed and treated with dignity by the midwife. Each 
      theme contained several sub-themes. CONCLUSION: The findings contribute insights 
      into how midwives can be educated to reduce fear of childbirth and promote
      positive birth experiences, despite the existence of negative memories of
      previous births. IMPLICATION FOR NURSING MANAGEMENT: In order to achieve
      continuity and a trusting relationship it is necessary to organise leadership and
      to adopt models that are flexible and support women's health.
FAU - Lyberg, Anne
AU  - Lyberg A
AD  - Centre for Women's, Family & Child Health, Faculty of Health Sciences, Vestfold
      University College, Tonsberg, Norway.
FAU - Severinsson, Elisabeth
AU  - Severinsson E
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Nurs Manag
JT  - Journal of nursing management
JID - 9306050
MH  - Adult
MH  - Continuity of Patient Care
MH  - Empathy
MH  - *Fear
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - *Leadership
MH  - *Midwifery
MH  - Models, Nursing
MH  - Norway
MH  - Nurse-Patient Relations
MH  - Nursing, Team/*organization & administration
MH  - Parturition/*psychology
MH  - Pregnancy
MH  - Trust
EDAT- 2010/07/09 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/07/09 06:00
PHST- 2010/07/09 06:00 [entrez]
PHST- 2010/07/09 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - JNM1103 [pii]
AID - 10.1111/j.1365-2834.2010.01103.x [doi]
PST - ppublish
SO  - J Nurs Manag. 2010 May;18(4):383-90. doi: 10.1111/j.1365-2834.2010.01103.x.


PMID- 20608796
OWN - NLM
STAT- MEDLINE
DCOM- 20110519
LR  - 20191210
IS  - 1476-4954 (Electronic)
IS  - 1476-4954 (Linking)
VI  - 24
IP  - 2
DP  - 2011 Feb
TI  - Is the caesarean section rate a performance indicator of an obstetric unit?
PG  - 204-7
LID - 10.3109/14767058.2010.496501 [doi]
AB  - The indications of caesarean section are increasing. The need to respect maternal
      desire in the decision making has been supported by law and ethics. Some of the
      other contributors to the increasing caesarean section rate are breech with
      failed external cephalic version, decreasing rate of trial of scar, increasing
      induction rate and electronic fetal heart rate monitoring and changing
      demography. Despite the adverse effects of caesarean section, the incidence of
      severe morbidity and mortality is low. The strategies put forward to reduce the
      caesarean section rate (CSR) have not been effective and in no country or
      province, the CSR has come down. CSR should not be looked at in isolation or as
      high or low. It is the product of changing obstetric practice and societal norms 
      and demographics. CSR not reflect the performance of a maternity unit.
FAU - Singh, Ruchi
AU  - Singh R
AD  - Royal Women's Hospital, Urogynaecology, Carlton, Melbourne, Australia.
FAU - Nath Trivedi, Amarendra
AU  - Nath Trivedi A
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Review
DEP - 20100707
PL  - England
TA  - J Matern Fetal Neonatal Med
JT  - The journal of maternal-fetal & neonatal medicine : the official journal of the
      European Association of Perinatal Medicine, the Federation of Asia and Oceania
      Perinatal Societies, the International Society of Perinatal Obstetricians
JID - 101136916
SB  - IM
MH  - *Birth Rate
MH  - Cesarean Section/adverse effects/*statistics & numerical data
MH  - Delivery Rooms/organization & administration/*statistics & numerical data
MH  - Delivery, Obstetric/statistics & numerical data
MH  - Efficiency, Organizational
MH  - Female
MH  - Humans
MH  - Postoperative Complications
MH  - Pregnancy
MH  - *Quality Indicators, Health Care
EDAT- 2010/07/09 06:00
MHDA- 2011/05/20 06:00
CRDT- 2010/07/09 06:00
PHST- 2010/07/09 06:00 [entrez]
PHST- 2010/07/09 06:00 [pubmed]
PHST- 2011/05/20 06:00 [medline]
AID - 10.3109/14767058.2010.496501 [doi]
PST - ppublish
SO  - J Matern Fetal Neonatal Med. 2011 Feb;24(2):204-7. doi:
      10.3109/14767058.2010.496501. Epub 2010 Jul 7.


PMID- 20608216
OWN - NLM
STAT- MEDLINE
DCOM- 20100726
LR  - 20121005
IS  - 0209-1712 (Print)
IS  - 0209-1712 (Linking)
VI  - 42
IP  - 1
DP  - 2010 Jan-Mar
TI  - [Are the hospital ethics committees necessary in Poland?].
PG  - 47-50
AB  - The role, and even the necessity of hospital ethics committees, is not
      universally agreed upon. In the 2005, the UNESCO advised the establishment of
      four types of bioethics committees at different levels: policy-making and/or
      advisory bioethics committees/commissions/councils at national levels (PMAs),
      health-professional association (HPAs) bioethics committees, health care/hospital
      ethics committees (HECs), and research ethics committees (RECs). Until recently
      in Poland, only RECs existed. The article discusses the necessity of establishing
      HECs nationwide. So far, only two bodies of this kind exist in two large,
      academic paediatric hospitals. In some other academic centers, institutional RECs
      try to act as HECs, but it is only a temporary solution. A nationwide discussion,
      and formal establishment of HECs will be necessary.
FAU - Czarkowski, Marek
AU  - Czarkowski M
AD  - Klinika Chorob Wewnetrznych i Endokrynologii, Warszawski Uniwersytet Medyczny.
      mczark@gmail.com
LA  - pol
PT  - English Abstract
PT  - Journal Article
TT  - Zasadnosc powolywania szpitalnych komisji etycznych w Polsce.
PL  - Poland
TA  - Anestezjol Intens Ter
JT  - Anestezjologia intensywna terapia
JID - 9424972
SB  - IM
MH  - Ethics Committees, Clinical/*organization & administration
MH  - Needs Assessment
MH  - Poland
MH  - Policy Making
MH  - Societies, Medical
EDAT- 2010/07/09 06:00
MHDA- 2010/07/27 06:00
CRDT- 2010/07/09 06:00
PHST- 2010/07/09 06:00 [entrez]
PHST- 2010/07/09 06:00 [pubmed]
PHST- 2010/07/27 06:00 [medline]
PST - ppublish
SO  - Anestezjol Intens Ter. 2010 Jan-Mar;42(1):47-50.


PMID- 20607980
OWN - NLM
STAT- MEDLINE
DCOM- 20100831
LR  - 20190917
IS  - 0370-8179 (Print)
IS  - 0370-8179 (Linking)
VI  - 138
IP  - 5-6
DP  - 2010 May-Jun
TI  - [Nosocomial infections at Clinical Centre in Kragujevac--prevalence study].
PG  - 337-42
AB  - INTRODUCTION: Nosocomial infections (NIs) are a serious health problem in
      hospitals worldwide and are followed by a series of consequences, medical,
      judicial, ethical and economic. OBJECTIVE: The main aim of this study was to
      assess the magnitude of NIs at the Clinical Centre in Kragujevac. METHODS: A
      prevalence study of nosocomial infections was conducted from 16th till 20th May, 
      2005, within Second National Prevalence Study of Nis in the Republic of Serbia.
      RESULTS: The study included 866 patients. 40 patients had a NI, thus the
      prevalence of patients with NIs and prevalence of NIs was the same, 4.6%. Among
      NIs, the most frequent were urinary infections (45.0%) followed by surgical-site 
      infections (17.5%), skin and soft tissue infections (15%) and pneumonia (12.5%). 
      The rate of NIs was highest at departments of orthopaedics and traumatological
      surgery (12.0%), followed by intensive care units (8.0%). Overall, 67.5% (27/40) 
      NIs were culture-proved; the leading pathogens were Escherichia coli (40.0%),
      followed by gram-negative bacteria (Pseudomonas species, Proteus mirabilis,
      Enterobacteriaceae with equal frequency of 8.0%). Nosocomial infections were
      significantly more frequent in patients aged > or = 65 years (p < 0.05), with
      longer hospitalization > or = 8 days (p < 0.00), in intensive care patients (p < 
      0.05), patients with an intravenous catheter (p < 0.00), urinary catheter (p <
      0.00), and those under antibiotic therapy (p < 0.00). CONCLUSION: This study
      showed that the prevalence of nosocomial infections in our hospital is similar to
      the prevalence in the developed countries. The study of prevalence provides a
      prompt insight into basic epidemiological and ethiological characteristics of
      nosocomial infections, hence identification of hospital priorities and the need
      to undertake appropriate prevention measures.
FAU - IIic, Milena
AU  - IIic M
FAU - Markovic-Denic, Ljiljana
AU  - Markovic-Denic L
LA  - srp
PT  - English Abstract
PT  - Journal Article
PL  - Serbia
TA  - Srp Arh Celok Lek
JT  - Srpski arhiv za celokupno lekarstvo
JID - 0027440
SB  - IM
MH  - Aged
MH  - Cross Infection/*epidemiology/microbiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Serbia/epidemiology
EDAT- 2010/07/09 06:00
MHDA- 2010/09/02 06:00
CRDT- 2010/07/09 06:00
PHST- 2010/07/09 06:00 [entrez]
PHST- 2010/07/09 06:00 [pubmed]
PHST- 2010/09/02 06:00 [medline]
AID - 10.2298/sarh1006337i [doi]
PST - ppublish
SO  - Srp Arh Celok Lek. 2010 May-Jun;138(5-6):337-42. doi: 10.2298/sarh1006337i.


PMID- 20607966
OWN - NLM
STAT- MEDLINE
DCOM- 20100819
LR  - 20100707
IS  - 0040-781X (Print)
IS  - 0040-781X (Linking)
VI  - 175
IP  - 25
DP  - 2010 Jun 28
TI  - Creation myths. In the beginning, Craig Venter 'created life' in a lab. Cue the
      eternal clash of science and ethics.
PG  - 60
FAU - Gibbs, Nancy
AU  - Gibbs N
LA  - eng
PT  - News
PL  - United States
TA  - Time
JT  - Time
JID - 9877130
MH  - Bacteria/genetics
MH  - Genes, Synthetic
MH  - Genetic Engineering/ethics
MH  - Science/*ethics
MH  - United States
EDAT- 2010/07/09 06:00
MHDA- 2010/08/20 06:00
CRDT- 2010/07/09 06:00
PHST- 2010/07/09 06:00 [entrez]
PHST- 2010/07/09 06:00 [pubmed]
PHST- 2010/08/20 06:00 [medline]
PST - ppublish
SO  - Time. 2010 Jun 28;175(25):60.


PMID- 20586880
OWN - NLM
STAT- MEDLINE
DCOM- 20101029
LR  - 20100630
IS  - 1365-2788 (Electronic)
IS  - 0964-2633 (Linking)
VI  - 54 Suppl 1
DP  - 2010 Mar
TI  - Counterpoints of care: two moments of struggle.
PG  - 5-15
LID - 10.1111/j.1365-2788.2009.01233.x [doi]
AB  - This paper examines the history of care in modern society and seeks to expose how
      deep transformations in care arise from wider social relations. From historical
      survey we may discern a series of transitional points, where the practice and the
      experience of care was greatly, sometimes suddenly, redefined. Each betrayed
      deeper political and ethical struggles that went to the core of social relations,
      and which weren't merely therapeutic in nature. This paper explores two such
      'moments'. I first examine the emergence of a new institutional landscape during 
      the middle industrial era, in the wake of a series of legal and political reforms
      that sought to settle a social order uprooted and distressed by raw
      modernisation. I provide a composite, yet incomplete view, of how this
      transformation proceeded in one urban setting, colonial Melbourne. In the second 
      instance, I review the ambitions and process of deinstitutionalisation in the
      late 20(th) century. Ostensibly, this reform sought, inter alia, to collapse the 
      great division between 'fit' and 'unfit' established in 1834. Again, empirical
      reference is made to the reconstitution of care in Melbourne, Australia, this
      time during its late 20th experience of institutional reform. The focus in this
      case is the process of downscaling and closure for a major congregate facility,
      Kew Cottages. The major conclusion is that periods of intense transition in the
      ideology and mode of care are reflective of wider social transformations not
      merely of therapeutic or institutional shifts.
FAU - Gleeson, B
AU  - Gleeson B
AD  - Urban Research Program, Griffith University, Nathan, QLD 4111, Australia.
      brendan.gleeson@griffith.edu.au
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Intellect Disabil Res
JT  - Journal of intellectual disability research : JIDR
JID - 9206090
SB  - IM
MH  - Australia
MH  - Deinstitutionalization/history
MH  - Delivery of Health Care/history
MH  - Disabled Persons/psychology/*rehabilitation
MH  - Health Services/history
MH  - History, 19th Century
MH  - History, 20th Century
MH  - Humans
MH  - Institutionalization/history
MH  - Social Environment
MH  - Social Isolation
EDAT- 2010/07/09 06:00
MHDA- 2010/10/30 06:00
CRDT- 2010/07/01 06:00
PHST- 2010/07/01 06:00 [entrez]
PHST- 2010/07/09 06:00 [pubmed]
PHST- 2010/10/30 06:00 [medline]
AID - JIR1233 [pii]
AID - 10.1111/j.1365-2788.2009.01233.x [doi]
PST - ppublish
SO  - J Intellect Disabil Res. 2010 Mar;54 Suppl 1:5-15. doi:
      10.1111/j.1365-2788.2009.01233.x.


PMID- 20607613
OWN - NLM
STAT- MEDLINE
DCOM- 20100819
LR  - 20211020
IS  - 1573-0980 (Electronic)
IS  - 1386-7415 (Linking)
VI  - 31
IP  - 4
DP  - 2010 Aug
TI  - Personhood and the practical.
PG  - 271-83
LID - 10.1007/s11017-010-9149-6 [doi]
AB  - Traditionally, it has been assumed that metaphysical and practical questions
      about personhood and personal identity are inherently linked. Neo-Lockean views
      that draw such a link have been problematic, leading to an opposing view that
      metaphysical and ethical questions about persons should be sharply distinguished.
      This paper argues that consideration of this issue suffers from an overly narrow 
      conception of the practical concerns associated with persons that focuses on
      higher-order capacities and fails to appreciate basic practical concerns more
      directly connected to our animality. A more inclusive alternative is proposed.
FAU - Schechtman, Marya
AU  - Schechtman M
AD  - Department of Philosophy, University of Illinois at Chicago, 1423 University Hall
      MC267, 601 S. Morgan St., Chicago, IL 60607-7114, USA. marya@uic.edu
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Theor Med Bioeth
JT  - Theoretical medicine and bioethics
JID - 9805378
SB  - IM
MH  - Bioethics
MH  - *Human Characteristics
MH  - Humans
MH  - Metaphysics
MH  - Moral Obligations
MH  - *Personhood
MH  - *Self Concept
EDAT- 2010/07/08 06:00
MHDA- 2010/08/20 06:00
CRDT- 2010/07/08 06:00
PHST- 2010/07/08 06:00 [entrez]
PHST- 2010/07/08 06:00 [pubmed]
PHST- 2010/08/20 06:00 [medline]
AID - 10.1007/s11017-010-9149-6 [doi]
PST - ppublish
SO  - Theor Med Bioeth. 2010 Aug;31(4):271-83. doi: 10.1007/s11017-010-9149-6.


PMID- 20607416
OWN - NLM
STAT- MEDLINE
DCOM- 20110207
LR  - 20101026
IS  - 1573-7403 (Electronic)
IS  - 1386-341X (Linking)
VI  - 13
IP  - 4
DP  - 2010 Dec
TI  - The autopsy was conducted "Under most inauspicious circumstances:" John Turner,
      Harvey Cushing's case XXXII, and his unwitting contributions to the early
      understanding of acromegaly.
PG  - 324-8
LID - 10.1007/s11102-010-0239-2 [doi]
AB  - Harvey Cushing's monograph The Pituitary Body and Its Disorders describes Case
      XXXII, a 36-year-old man who presented with gigantism in 1910. The detailed
      post-mortem exam findings are prefaced with a cryptic statement, describing
      "inauspicious circumstances" surrounding the autopsy. Although contemporary
      biographies of Cushing have offered insight into these circumstances, the
      original surgical file for Case XXXII has not been previously reviewed. The
      original Johns Hopkins Hospital surgical records were reviewed, and the case of
      John Turner, who Cushing identified by name in his monograph The Pituitary Body
      and Its Disorders, was selected for further review. A review of the original
      surgical file revealed a typewritten note by Dr. Crowe, one of the surgeons who
      performed the post-mortem exam, with a handwritten addendum by Dr. Cushing. This 
      document provides detail regarding the "inauspicious circumstances" surrounding
      the autopsy. Namely, the autopsy was conducted without permission of the family, 
      during the funeral service, following a payment to the undertaker. The new
      information regarding the autopsy of John Turner offers insight into the
      previously incompletely described circumstances surrounding the autopsy.
      Additionally, the case illuminates the obligations and ethical quandaries that
      physician-scientists face.
FAU - Pendleton, Courtney
AU  - Pendleton C
AD  - Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.
FAU - Wand, Gary
AU  - Wand G
FAU - Quinones-Hinojosa, Alfredo
AU  - Quinones-Hinojosa A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Pituitary
JT  - Pituitary
JID - 9814578
SB  - IM
MH  - Acromegaly/*diagnosis
MH  - Adult
MH  - Autopsy
MH  - Humans
MH  - Male
MH  - Medical Records
EDAT- 2010/07/08 06:00
MHDA- 2011/02/08 06:00
CRDT- 2010/07/08 06:00
PHST- 2010/07/08 06:00 [entrez]
PHST- 2010/07/08 06:00 [pubmed]
PHST- 2011/02/08 06:00 [medline]
AID - 10.1007/s11102-010-0239-2 [doi]
PST - ppublish
SO  - Pituitary. 2010 Dec;13(4):324-8. doi: 10.1007/s11102-010-0239-2.


PMID- 20606994
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 0974-5157 (Electronic)
IS  - 0974-2077 (Linking)
VI  - 3
IP  - 1
DP  - 2010 Jan
TI  - The ethics of aesthetic surgery.
PG  - 38-40
LID - 10.4103/0974-2077.63396 [doi]
AB  - Advances in plastic and reconstructive surgery have revolutionized the management
      of patients suffering from disfiguring congenital abnormalities, burns and skin
      cancers. The demand for aesthetic surgery has increased in recent years, as our
      culture has become more concerned with image and appearance. Several ethical
      considerations such as patient's right for informed counseling, beneficience and 
      maleficience need to be given careful consideration.
FAU - Mousavi, S R
AU  - Mousavi SR
AD  - Professor of Surgery and Cosmetic and Ethics, Shohada Medical Center, Tajrish
      University of Shahid Beheshti Medical Sciences, Tehran Iran.
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Cutan Aesthet Surg
JT  - Journal of cutaneous and aesthetic surgery
JID - 101525405
PMC - PMC2890136
OTO - NOTNLM
OT  - Autonomy
OT  - cosmetic surgery
OT  - ethics
EDAT- 2010/07/08 06:00
MHDA- 2010/07/08 06:01
CRDT- 2010/07/08 06:00
PHST- 2010/07/08 06:00 [entrez]
PHST- 2010/07/08 06:00 [pubmed]
PHST- 2010/07/08 06:01 [medline]
AID - 10.4103/0974-2077.63396 [doi]
PST - ppublish
SO  - J Cutan Aesthet Surg. 2010 Jan;3(1):38-40. doi: 10.4103/0974-2077.63396.


PMID- 20606653
OWN - NLM
STAT- MEDLINE
DCOM- 20100813
LR  - 20100707
IS  - 1572-0241 (Electronic)
IS  - 0002-9270 (Linking)
VI  - 105
IP  - 7
DP  - 2010 Jul
TI  - Consultation etiquette: a proposed set of guidelines.
PG  - 1477-8
LID - 10.1038/ajg.2010.163 [doi]
AB  - Too often, actions and decisions affecting patient care are determined by
      expediency, cost-effectiveness, and time constraints. At risk of sacrifice are
      ethics and professionalism, pillars essential to the very structure of medical
      practice. In particular, there appears to be an erosion of consultation
      etiquette-exchanges between physicians and patients as well as among physicians. 
      While methods to maximize efficiency are essential to medical practice, they
      should not come at the expense of etiquette. To improve patient care and
      strengthen relationships between patients and physicians, as well as
      relationships between referring and consulting physicians, a set of guidelines
      for improving consultation etiquette is proposed.
FAU - Rogers, Arvey I
AU  - Rogers AI
AD  - Internal Medicine/Gastroenterology, Miller School of Medicine, University of
      Miami, Miami, FL, USA. RVIMD@aol.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Gastroenterol
JT  - The American journal of gastroenterology
JID - 0421030
SB  - IM
MH  - Gastroenterology/ethics/*standards
MH  - Humans
MH  - *Physician-Patient Relations/ethics
MH  - Practice Guidelines as Topic/*standards
MH  - Referral and Consultation/ethics/*standards
EDAT- 2010/07/08 06:00
MHDA- 2010/08/14 06:00
CRDT- 2010/07/08 06:00
PHST- 2010/07/08 06:00 [entrez]
PHST- 2010/07/08 06:00 [pubmed]
PHST- 2010/08/14 06:00 [medline]
AID - ajg2010163 [pii]
AID - 10.1038/ajg.2010.163 [doi]
PST - ppublish
SO  - Am J Gastroenterol. 2010 Jul;105(7):1477-8. doi: 10.1038/ajg.2010.163.


PMID- 20606571
OWN - NLM
STAT- MEDLINE
DCOM- 20110325
LR  - 20141120
IS  - 1473-5571 (Electronic)
IS  - 0269-9370 (Linking)
VI  - 24
IP  - 14
DP  - 2010 Sep 10
TI  - United States global health policy: HIV/AIDS, maternal and child health, and The 
      President's Emergency Plan for AIDS Relief (PEPFAR).
PG  - 2145-9
LID - 10.1097/QAD.0b013e32833cbb41 [doi]
AB  - The Obama administration has unveiled a new 6-year, $63 billion Global Health
      Initiative. In addition to the reauthorization of the President's Emergency Plan 
      for AIDS Relief (PEPFAR) to fund HIV/AIDS, tuberculosis, and malaria, the plan
      also supports maternal and child health (MCH) initiatives that are rooted in a
      proposal known as the Mother and Child Campaign. The architects of the Obama
      administration's Global Health Initiative recommend funding the Mother and Child 
      Campaign at the expense of future funding increases for PEPFAR. The idea that
      differing global health initiatives must compete with each other lacks not only
      ethical legitimacy but also scientific merit. We believe that MCH need not to be 
      framed in opposition to PEPFAR. Confronting illness in isolation - whether by
      funding PEPFAR at the expense of programs that target MCH or vice versa - cannot 
      be our way forward. Given the intimate connection between HIV/AIDS and MCH, we
      affirm supporting PEPFAR and MCH programs together. We argue that policies that
      de-emphasize PEPFAR threaten to undermine, rather than support, MCH in countries 
      with high HIV/AIDS prevalence. PEPFAR has directly and indirectly supported the
      care and treatment of other milieu specific diseases, including those afflicting 
      mothers and children, bringing about broad benefits to the primary healthcare
      systems of recipient countries. We advocate the vertical integration of MCH
      initiatives into PEPFAR in order to create a comprehensive approach to addressing
      MCH against the global backdrop of HIV/AIDS.
FAU - Leeper, Sarah C
AU  - Leeper SC
AD  - University of Colorado, Aurora, 80045, USA. sleeper.areddi.globalhealth@gmail.com
FAU - Reddi, Anand
AU  - Reddi A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - AIDS
JT  - AIDS (London, England)
JID - 8710219
SB  - IM
MH  - Adult
MH  - Child
MH  - Child Welfare/*legislation & jurisprudence
MH  - Child, Preschool
MH  - Female
MH  - Global Health
MH  - Government Programs
MH  - HIV Infections/*drug therapy/epidemiology/prevention & control
MH  - Health Policy/*legislation & jurisprudence
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - International Cooperation
MH  - Malaria/*drug therapy/epidemiology/prevention & control
MH  - Male
MH  - Maternal Welfare/*legislation & jurisprudence
MH  - Pregnancy
MH  - Tuberculosis/*drug therapy/epidemiology
MH  - United States
EDAT- 2010/07/08 06:00
MHDA- 2011/03/26 06:00
CRDT- 2010/07/08 06:00
PHST- 2010/07/08 06:00 [entrez]
PHST- 2010/07/08 06:00 [pubmed]
PHST- 2011/03/26 06:00 [medline]
AID - 10.1097/QAD.0b013e32833cbb41 [doi]
PST - ppublish
SO  - AIDS. 2010 Sep 10;24(14):2145-9. doi: 10.1097/QAD.0b013e32833cbb41.


PMID- 20606000
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20211020
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 7
DP  - 2010 Jul
TI  - Non-equivalent stringency of ethical review in the Baltic States: a sign of a
      systematic problem in Europe?
PG  - 435-9
LID - 10.1136/jme.2009.035030 [doi]
AB  - We analyse the system of ethical review of human research in the Baltic States by
      introducing the principle of equivalent stringency of ethical review, that is,
      research projects imposing equal risks and inconveniences on research
      participants should be subjected to equally stringent review procedures. We
      examine several examples of non-equivalence or asymmetry in the system of ethical
      review of human research: (1) the asymmetry between rather strict regulations of 
      clinical drug trials and relatively weaker regulations of other types of clinical
      biomedical research and (2) gaps in ethical review in the area of non-biomedical 
      human research where some sensitive research projects are not reviewed by
      research ethics committees at all. We conclude that non-equivalent stringency of 
      ethical review is at least partly linked to the differences in scope and binding 
      character of various international legal instruments that have been shaping the
      system of ethical review in the Baltic States. Therefore, the Baltic example
      could also serve as an object lesson to other European countries which might be
      experiencing similar problems.
FAU - Gefenas, E
AU  - Gefenas E
AD  - Department of Medical History and Ethics, Vilnius University, MK Ciurlionio St
      21/27, Vilnius LT-03101, Lithuania. eugenijus.gefenas@mf.vu.lt
FAU - Dranseika, V
AU  - Dranseika V
FAU - Cekanauskaite, A
AU  - Cekanauskaite A
FAU - Hug, K
AU  - Hug K
FAU - Mezinska, S
AU  - Mezinska S
FAU - Peicius, E
AU  - Peicius E
FAU - Silis, V
AU  - Silis V
FAU - Soosaar, A
AU  - Soosaar A
FAU - Strosberg, M
AU  - Strosberg M
LA  - eng
GR  - R25 TW007085/TW/FIC NIH HHS/United States
GR  - R25 TW007085-07/TW/FIC NIH HHS/United States
GR  - R25TW007085/TW/FIC NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Baltic States
MH  - Biomedical Research/*ethics/legislation & jurisprudence
MH  - Ethical Review/*standards
MH  - Europe
MH  - Human Experimentation/*ethics/legislation & jurisprudence
MH  - Humans
MH  - Risk
PMC - PMC3072805
MID - NIHMS281058
EDAT- 2010/07/08 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/07/08 06:00
PHST- 2010/07/08 06:00 [entrez]
PHST- 2010/07/08 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - 36/7/435 [pii]
AID - 10.1136/jme.2009.035030 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Jul;36(7):435-9. doi: 10.1136/jme.2009.035030.


PMID- 20605999
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20100707
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 7
DP  - 2010 Jul
TI  - Discrepancies between research advertisements and disclosure of study locations
      in trial registrations for USA-sponsored research in Russia.
PG  - 431-4
LID - 10.1136/jme.2010.035378 [doi]
AB  - BACKGROUND AND AIM: The full disclosure of all locations at which research is
      conducted is an important requirement of clinical trial registration. Yet, little
      is known about how well researchers and sponsors disclose this information in
      their registrations. The aim of this study is to examine the adequacy of study
      location disclosure on http://ClinicalTrials.gov/ for recent USA-sponsored
      research in the Russian Federation. METHODS AND RESULTS: Information from
      advertisements for clinical research participation opportunities in Russia was
      compared with that in the corresponding trial registration in
      http://ClinicalTrials.gov/. Of 218 USA-sponsored trials advertised to Russian
      patients and physicians, nearly one-third did not disclose Russia as a study
      location in the registration. Longer trials were more likely to specify Russia as
      a study location. CONCLUSION: This study found that recent USA-sponsored clinical
      trials advertised to patients and physicians in the Russian Federation often do
      not specify Russia as a study location in their registrations on
      http://ClinicalTrials.gov/. The failure to fully disclose the locations at which 
      research takes place undermines patients' ability to access information about
      potentially beneficial research opportunities, limits access to information,
      which may be important for identifying or avoiding ethically questionable
      practices, and may frustrate the ability to interpret the results of research.
FAU - Patrone, D
AU  - Patrone D
AD  - Philosophy Department, Union Graduate College-Mt Sinai School of Medicine
      Bioethics Program, Union College, 80 Nott Terrace, Schenectady, NY 13847, USA.
      dpatrone@gmail.com
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Clinical Trials as Topic
MH  - Databases, Bibliographic
MH  - *Disclosure
MH  - Humans
MH  - Registries/*standards
MH  - Russia
EDAT- 2010/07/08 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/07/08 06:00
PHST- 2010/07/08 06:00 [entrez]
PHST- 2010/07/08 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - 36/7/431 [pii]
AID - 10.1136/jme.2010.035378 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Jul;36(7):431-4. doi: 10.1136/jme.2010.035378.


PMID- 20605998
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20171116
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 7
DP  - 2010 Jul
TI  - Research ethics in dissertations: ethical issues and complexity of reasoning.
PG  - 425-30
LID - 10.1136/jme.2009.034561 [doi]
AB  - BACKGROUND: Conducting ethically sound research is a fundamental principle of
      scientific inquiry. Recent research has indicated that ethical concerns are
      insufficiently dealt with in dissertations. PURPOSE: To examine which research
      ethical topics were addressed and how these were presented in terms of complexity
      of reasoning in Swedish nurses' dissertations. METHODS: Analyses of ethical
      content and complexity of ethical reasoning were performed on 64 Swedish nurses' 
      PhD dissertations dated 2007. RESULTS: A total of seven ethical topics were
      identified: ethical approval (94% of the dissertations), information and informed
      consent (86%), confidentiality (67%), ethical aspects of methods (61%), use of
      ethical principles and regulations (39%), rationale for the study (20%) and fair 
      participant selection (14%). Four of those of topics were most frequently
      addressed: the majority of dissertations (72%) included 3-5 issues. While many
      ethical concerns, by their nature, involve systematic concepts or metasystematic 
      principles, ethical reasoning scored predominantly at lesser levels of
      complexity: abstract (6% of the dissertations), formal (84%) and systematic
      (10%). CONCLUSIONS: Research ethics are inadequately covered in most
      dissertations by nurses in Sweden. Important ethical concerns are missing, and
      the complexity of reasoning on ethical principles, motives and implications is
      insufficient. This is partly due to traditions and norms that discount ethical
      concerns but is probably also a reflection of the ability of PhD students and
      supervisors to handle complexity in general. It is suggested that the importance 
      of ethical considerations should be emphasised in graduate and post-graduate
      studies and that individuals with capacity to deal with systematic and
      metasystematic concepts are recruited to senior research positions.
FAU - Kjellstrom, S
AU  - Kjellstrom S
AD  - Institute of Gerontology, School of Health Sciences, Jonkoping University, PO Box
      1026, SE-551 11 Jonkoping, Sweden. sofia.kjellstrom@hhj.hj.se
FAU - Ross, S N
AU  - Ross SN
FAU - Fridlund, B
AU  - Fridlund B
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Academic Dissertations as Topic
MH  - Confidentiality
MH  - *Ethics, Research
MH  - Humans
MH  - Informed Consent
MH  - Nursing Research/*ethics
MH  - *Problem Solving
MH  - Sweden
EDAT- 2010/07/08 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/07/08 06:00
PHST- 2010/07/08 06:00 [entrez]
PHST- 2010/07/08 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - 36/7/425 [pii]
AID - 10.1136/jme.2009.034561 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Jul;36(7):425-30. doi: 10.1136/jme.2009.034561.


PMID- 20605996
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20151119
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 7
DP  - 2010 Jul
TI  - Analysis of the status of informed consent in medical research involving human
      subjects in public hospitals in Shanghai.
PG  - 415-9
LID - 10.1136/jme.2009.034629 [doi]
AB  - OBJECTIVES: The objectives of the study are to understand the current practice of
      informed consent in medical research in public hospitals in Shanghai, and to
      share our views with other countries, especially developing countries. METHODS:
      In the study, 145 consent forms (CFs) of the selected research projects in eight 
      public hospitals with ethics committees in Shanghai were audited, and the
      principle investigators (PIs) of these research projects and 40 student subjects 
      who had participated in clinical drug tests were surveyed by questionnaires.
      RESULTS: The CFs of medical researches in public hospitals with ethics committees
      in Shanghai were generally acceptable. However, there were some defects in the
      CFs. Although most of the surveyed PIs had correct recognition of informed
      consent, some processes of informed consent were not in accordance with generally
      accepted requirements. A large number of the PIs considered the greatest
      difficulty with informal consent was lack of correct recognition of subjects or
      legally authorised representatives on medical research. DISCUSSION: Informed
      consent in medical research should consider the research ethics, the background
      of potential subjects, the local resources and culture of medical research. In
      addition, special protection is needed for student subjects in informed consent
      as well as efforts for building and restoring the public's trust in biomedical
      research. CONCLUSION: The informed consent in Shanghai's public hospitals with
      ethics committees was generally acceptable and the achievement of adequate
      informed consent is influenced by many factors.
FAU - Jianping, Wang
AU  - Jianping W
AD  - Department of Hospital Management, School of Public Health, Fu Dan University,
      Shanghai 200032, PR China.
FAU - Li, Lan
AU  - Li L
FAU - Xue, Di
AU  - Xue D
FAU - Tang, Zhongjin
AU  - Tang Z
FAU - Jia, Xieyang
AU  - Jia X
FAU - Wu, Rong
AU  - Wu R
FAU - Xi, Yiqun
AU  - Xi Y
FAU - Wang, Tong
AU  - Wang T
FAU - Zhou, Ping
AU  - Zhou P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Biomedical Research
MH  - China
MH  - Consent Forms/standards
MH  - *Ethical Review
MH  - Ethics Committees
MH  - *Ethics, Medical
MH  - Hospitals, Public
MH  - Humans
MH  - Informed Consent/*standards
MH  - Surveys and Questionnaires
EDAT- 2010/07/08 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/07/08 06:00
PHST- 2010/07/08 06:00 [entrez]
PHST- 2010/07/08 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - 36/7/415 [pii]
AID - 10.1136/jme.2009.034629 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Jul;36(7):415-9. doi: 10.1136/jme.2009.034629.


PMID- 20605995
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20100707
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 7
DP  - 2010 Jul
TI  - Deliberative ethics in a biomedical institution: an example of integration
      between science and ethics.
PG  - 409-14
LID - 10.1136/jme.2009.031674 [doi]
AB  - The deliberative ethics guidelines elaborated and implemented by members of the
      IFOM-IEO Campus (Firc Institute of Molecular Oncology (IFOM) and the European
      Institute of Oncology (IEO)). These should serve the dual purpose of establishing
      a minimal set of standard rules for bioethical debate and any ensuing
      decision-making process, especially for the perspective of providing real
      instruments to foster public engagement and public awareness on the ethical
      issues involved in biomedical research. It is shown that these guidelines
      instantiate the scheme of one of the correct ways of debating formalised by the
      western thought.
FAU - Boniolo, G
AU  - Boniolo G
AD  - Istituto FIRC di Oncologia Molecolare, Via Adamello 16, Milan 20139, Italy.
      giovanni.boniolo@ifom-ieo-campus.it
FAU - Di Fiore, P P
AU  - Di Fiore PP
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Academies and Institutes/organization & administration
MH  - *Bioethics
MH  - Biomedical Research/*ethics
MH  - Decision Making/*ethics
MH  - Ethics Committees
MH  - Humans
MH  - Organizational Objectives
MH  - Practice Guidelines as Topic
EDAT- 2010/07/08 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/07/08 06:00
PHST- 2010/07/08 06:00 [entrez]
PHST- 2010/07/08 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - 36/7/409 [pii]
AID - 10.1136/jme.2009.031674 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Jul;36(7):409-14. doi: 10.1136/jme.2009.031674.


PMID- 20605992
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20100707
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 7
DP  - 2010 Jul
TI  - Informing family members about a hereditary predisposition to cancer: attitudes
      and practices among clinical geneticists.
PG  - 391-5
LID - 10.1136/jme.2009.033324 [doi]
AB  - If a hereditary predisposition to colorectal cancer or breast cancer is
      diagnosed, most guidelines state that clinical geneticists should request index
      patients to inform their at-risk relatives about the existence of this condition 
      in their family, thus enabling them to consider presymptomatic genetic testing.
      Those identified as mutation carriers can undertake strategies to reduce their
      risk of developing the disease or to facilitate early diagnosis. This procedure
      of informing relatives through the index patient has been criticised, as it
      results in relatively few requests for genetic testing, conceivably because a
      certain number of relatives remain uninformed. This pilot study explored
      attitudes toward informing family members and relevant practices among clinical
      geneticists. In general, clinical geneticists consider it to be in the interests 
      of family members to be informed and acknowledge that this goal is not
      accomplished by current procedures. The reasons given for maintaining present
      practices despite this include clinical 'mores', uncertainty about the legal
      right of doctors to inform family members themselves, and, importantly, a lack of
      resources. We discuss these reasons from an ethical point of view and conclude
      that they are partly uninformed and inconsistent. If informing relatives is
      considered to be in their best interests, clinical geneticists should consider
      informing relatives themselves. In the common situation in which index patients
      do not object to informing relatives, no legal obstacles prevent geneticists from
      doing so. An evaluation of these findings among professionals may lead to a more 
      active approach in clinical practice.
FAU - Stol, Yrrah H
AU  - Stol YH
AD  - University of Amsterdam/Centre for Society and Genomics, Nijmegen, Amsterdam, The
      Netherlands. yrrah_stol@yahoo.com
FAU - Menko, Fred H
AU  - Menko FH
FAU - Westerman, Marjan J
AU  - Westerman MJ
FAU - Janssens, Rien M J P A
AU  - Janssens RM
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Family
MH  - *Genetic Predisposition to Disease
MH  - Genetic Services
MH  - Genetic Testing
MH  - *Genetics, Medical/ethics
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Neoplasms/*genetics
MH  - Netherlands
MH  - Physician's Role
MH  - Pilot Projects
MH  - *Truth Disclosure
EDAT- 2010/07/08 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/07/08 06:00
PHST- 2010/07/08 06:00 [entrez]
PHST- 2010/07/08 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - 36/7/391 [pii]
AID - 10.1136/jme.2009.033324 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Jul;36(7):391-5. doi: 10.1136/jme.2009.033324.


PMID- 20605991
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20100707
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 7
DP  - 2010 Jul
TI  - Ethical considerations for classifying patients as 'palliative' when calculating 
      Hospital Standardised Mortality Ratios.
PG  - 387-90
LID - 10.1136/jme.2010.035451 [doi]
AB  - The Hospital Standardised Mortality Ratio (HSMR) is a commonly used measure of
      hospital mortality that is standardised for age, comorbidities and other factors.
      By tradition, this statistic has always excluded patients classified as
      'palliative'. The HSMR has never been validated as a reliable measure of quality 
      of care, and it can be very hard to interpret, partly due to difficulties with
      defining and applying the term 'palliative'. In this paper, we review the
      Canadian experience with the palliative status flag, and explain why it is so
      difficult to define and apply consistently. We also highlight some potential
      concerns about clinicians labelling inpatients as 'palliative' during their
      admission. Finally, we propose an organisational ethics framework, and six
      specific suggestions for hospitals to use when publishing statistics such as the 
      HSMR.
FAU - Downar, James
AU  - Downar J
AD  - Department of Medicine, University Health Network, Toronto, Canada.
      james.downar@utoronto.ca
FAU - Sibbald, Robert
AU  - Sibbald R
FAU - Lazar, Neil M
AU  - Lazar NM
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Diagnosis-Related Groups
MH  - *Ethics, Medical
MH  - *Hospital Mortality
MH  - Humans
MH  - Palliative Care/*statistics & numerical data
MH  - Quality Assurance, Health Care/*ethics/organization & administration
EDAT- 2010/07/08 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/07/08 06:00
PHST- 2010/07/08 06:00 [entrez]
PHST- 2010/07/08 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - 36/7/387 [pii]
AID - 10.1136/jme.2010.035451 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Jul;36(7):387-90. doi: 10.1136/jme.2010.035451.


PMID- 20605990
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20100707
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 7
DP  - 2010 Jul
TI  - Coercive offers and research participation: a comment on Wertheimer and Miller.
PG  - 383-4
LID - 10.1136/jme.2010.035931 [doi]
AB  - Concepts such as 'coercion' and 'inducement' are often used within bioethics
      without much reflection upon what they mean. This is particularly so in research 
      ethics where they are assumed to imply that payment for research participation is
      unethical. Wertheimer and Miller advance our thinking about these concepts and
      research ethics in a significant way, specifically by questioning the possibility
      of genuine offers ever being coercive. This commentary argues that they are right
      to question this assumption, however, more needs to be said about the plausible
      coercive offer cases and to explain the normativity of these cases.
FAU - McMillan, John
AU  - McMillan J
AD  - School of Medicine, Flinders Medical Centre, Flinders University, Adelaide, SA
      5001, Australia. john.mcmillan@flinders.edu.au
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Clinical Trials as Topic/ethics
MH  - *Coercion
MH  - *Ethics, Research
MH  - Humans
MH  - Informed Consent/ethics
MH  - Patient Participation/*economics
EDAT- 2010/07/08 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/07/08 06:00
PHST- 2010/07/08 06:00 [entrez]
PHST- 2010/07/08 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - 36/7/383 [pii]
AID - 10.1136/jme.2010.035931 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Jul;36(7):383-4. doi: 10.1136/jme.2010.035931.


PMID- 20605728
OWN - NLM
STAT- MEDLINE
DCOM- 20111017
LR  - 20110510
IS  - 1879-0461 (Electronic)
IS  - 1040-8428 (Linking)
VI  - 78
IP  - 3
DP  - 2011 Jun
TI  - Suicide and cancer: where do we go from here?
PG  - 206-19
LID - 10.1016/j.critrevonc.2010.05.005 [doi]
AB  - Although suicide in cancer patients is a burdening public health problem with
      ethical, medical and psychiatric implications, it still has to be clarified why
      cancer patients commit suicide and how cancer suicides differ from others.
      Therefore, a review of the literature on suicide and suicidal ideation in cancer 
      patients was conducted, starting from an overview of these issues in the general 
      population. Evidence suggests that suicidality in the general population can be
      explained according to a genetic and psychological vulnerability to stress. The
      psychological and physical stressors found to be associated with suicide in
      cancer patients corroborate this model. Nevertheless, based on the well-described
      immunological disturbances due to cancer, we propose that suicide is not just a
      secondary reaction to cancer but is linked to an intrinsic bio-psychological
      vulnerability to distress. Upcoming studies should better characterize the
      neurobiology of suicidality in cancer, opening new avenues for treatment and
      prevention.
CI  - Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Spoletini, Ilaria
AU  - Spoletini I
AD  - IRCCS Santa Lucia Foundation, Rome, Italy.
FAU - Gianni, Walter
AU  - Gianni W
FAU - Caltagirone, Carlo
AU  - Caltagirone C
FAU - Madaio, Raffaele
AU  - Madaio R
FAU - Repetto, Lazzaro
AU  - Repetto L
FAU - Spalletta, Gianfranco
AU  - Spalletta G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100601
PL  - Netherlands
TA  - Crit Rev Oncol Hematol
JT  - Critical reviews in oncology/hematology
JID - 8916049
SB  - IM
MH  - Humans
MH  - Neoplasms/*psychology
MH  - Risk Factors
MH  - Suicide/prevention & control/*psychology/statistics & numerical data
EDAT- 2010/07/08 06:00
MHDA- 2011/10/18 06:00
CRDT- 2010/07/08 06:00
PHST- 2009/09/14 00:00 [received]
PHST- 2010/04/26 00:00 [revised]
PHST- 2010/05/07 00:00 [accepted]
PHST- 2010/07/08 06:00 [entrez]
PHST- 2010/07/08 06:00 [pubmed]
PHST- 2011/10/18 06:00 [medline]
AID - S1040-8428(10)00125-3 [pii]
AID - 10.1016/j.critrevonc.2010.05.005 [doi]
PST - ppublish
SO  - Crit Rev Oncol Hematol. 2011 Jun;78(3):206-19. doi:
      10.1016/j.critrevonc.2010.05.005. Epub 2010 Jun 1.


PMID- 20605389
OWN - NLM
STAT- MEDLINE
DCOM- 20111214
LR  - 20110913
IS  - 0736-4679 (Print)
IS  - 0736-4679 (Linking)
VI  - 41
IP  - 3
DP  - 2011 Sep
TI  - A randomized trial comparing two cuffed emergency cricothyrotomy devices using a 
      wire-guided and a catheter-over-needle technique.
PG  - 326-32
LID - 10.1016/j.jemermed.2010.04.008 [doi]
AB  - BACKGROUND: According to different algorithms of airway management, emergency
      cricothyrotomy is the final step in managing the otherwise inaccessible airway.
      As an alternative to an open surgical procedure, minimally invasive approaches
      exist. Various sets for different methods are commercially available. QuickTrach 
      (VBM Medizintechnik GmbH, Sulz am Neckar, Germany) contains a plastic cannula
      over a metal needle for direct placement in the trachea, whereas a guide-wire is 
      used for the actual placement of the cannula in the Melker Set (Cook Group
      Incorporated, Bloomington, IN). OBJECTIVE: We hypothesize that the direct
      puncture involving less discrete steps is faster to perform. However, it will
      lead to more complications due to the higher force needed to place the relatively
      thick needle. METHOD: After approval of the local ethics committee, the study was
      performed on cadavers of 16 adult sheep. A wire-guided cricothyrotomy was
      compared with a catheter-over-needle technique. Successful placement and
      performance time were compared. Complication rate and maximal achieved airway
      pressure were evaluated. Data is given as mean and interquartile range, and
      Mann-Whitney U-test (p < 0.05) for significant differences. RESULTS: With the
      wire-guided technique, successful placement was possible in all attempts. The
      catheter-over-needle method was successful in 63% and had a higher complication
      rate (75% vs. 13%). The cannula-over-needle method allowed a faster
      cricothyrotomy (32 [2-34] vs. 53 [52-56] s). Both methods allowed the delivery of
      similar maximal airway pressures (50 [44-51] vs. 48 [43-53] mbar). CONCLUSION:
      The wire-guided method proved to be the more reliable technique, leading to fewer
      complications. However, the direct puncture was faster to perform. Placed
      accurately, both devices allowed sufficient ventilation.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Metterlein, Thomas
AU  - Metterlein T
AD  - Department of Anesthesiology, University of Wurzburg, Wurzburg, Germany.
FAU - Frommer, Matthias
AU  - Frommer M
FAU - Ginzkey, Christian
AU  - Ginzkey C
FAU - Becher, Jan
AU  - Becher J
FAU - Schuster, Frank
AU  - Schuster F
FAU - Roewer, Norbert
AU  - Roewer N
FAU - Kranke, Peter
AU  - Kranke P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100607
PL  - United States
TA  - J Emerg Med
JT  - The Journal of emergency medicine
JID - 8412174
SB  - IM
MH  - Animals
MH  - Cadaver
MH  - Cricoid Cartilage/*surgery
MH  - Emergency Medicine/*methods
MH  - Random Allocation
MH  - Sheep
MH  - Thyroid Cartilage/*surgery
MH  - Tracheotomy/*instrumentation/methods
EDAT- 2010/07/08 06:00
MHDA- 2011/12/15 06:00
CRDT- 2010/07/08 06:00
PHST- 2009/04/23 00:00 [received]
PHST- 2009/11/15 00:00 [revised]
PHST- 2010/04/04 00:00 [accepted]
PHST- 2010/07/08 06:00 [entrez]
PHST- 2010/07/08 06:00 [pubmed]
PHST- 2011/12/15 06:00 [medline]
AID - S0736-4679(10)00261-1 [pii]
AID - 10.1016/j.jemermed.2010.04.008 [doi]
PST - ppublish
SO  - J Emerg Med. 2011 Sep;41(3):326-32. doi: 10.1016/j.jemermed.2010.04.008. Epub
      2010 Jun 7.


PMID- 20604959
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1744-859X (Electronic)
IS  - 1744-859X (Linking)
VI  - 9
DP  - 2010 Jul 6
TI  - The 'antisocial' person: an insight in to biology, classification and current
      evidence on treatment.
PG  - 31
LID - 10.1186/1744-859X-9-31 [doi]
AB  - BACKGROUND: This review analyses and summarises the recent advances in
      understanding the neurobiology of violence and empathy, taxonomical issues on
      defining personality disorders characterised by disregard for social norms,
      evidence for efficacy of different treatment modalities and ethical implications 
      in defining 'at-risk' individuals for preventive interventions. METHODS: PubMed
      was searched with the keywords 'antisocial personality disorder', 'dissocial
      personality disorder' and 'psychopathy'. The search was limited to articles
      published in English over the last 10 years (1999 to 2009) RESULTS: Both
      diagnostic manuals used in modern psychiatry, the Diagnostic and Statistical
      Manual published by the American Psychiatric Association and the International
      Classification of Diseases published by the World Health Organization, identify a
      personality disorder sharing similar traits. It is termed antisocial personality 
      disorder in the diagnostic and statistical manual and dissocial personality
      disorder in the International Classification of Diseases. However, some authors
      query the ability of the existing manuals to identify a special category termed
      'psychopathy', which in their opinion deserves special attention. On
      treatment-related issues, many psychological and behavioural therapies have shown
      success rates ranging from 25% to 62% in different cohorts. Multisystemic therapy
      and cognitive behaviour therapy have been proven efficacious in many trials.
      There is no substantial evidence for the efficacy of pharmacological therapy.
      Currently, the emphasis is on early identification and prevention of antisocial
      behaviour despite the ethical implications of defining at-risk children.
      CONCLUSIONS: Further research is needed in the areas of neuroendocrinological
      associations of violent behaviour, taxonomic existence of psychopathy and
      efficacy of treatment modalities.
FAU - Rodrigo, Chaturaka
AU  - Rodrigo C
AD  - Mental Health Unit, Provincial General Hospital, Ratnapura, Sri Lanka.
      chaturaka.rodrigo@gmail.com.
FAU - Rajapakse, Senaka
AU  - Rajapakse S
FAU - Jayananda, Gamini
AU  - Jayananda G
LA  - eng
PT  - Journal Article
DEP - 20100706
PL  - England
TA  - Ann Gen Psychiatry
JT  - Annals of general psychiatry
JID - 101236515
PMC - PMC2910031
EDAT- 2010/07/08 06:00
MHDA- 2010/07/08 06:01
CRDT- 2010/07/08 06:00
PHST- 2010/04/12 00:00 [received]
PHST- 2010/07/06 00:00 [accepted]
PHST- 2010/07/08 06:00 [entrez]
PHST- 2010/07/08 06:00 [pubmed]
PHST- 2010/07/08 06:01 [medline]
AID - 1744-859X-9-31 [pii]
AID - 10.1186/1744-859X-9-31 [doi]
PST - epublish
SO  - Ann Gen Psychiatry. 2010 Jul 6;9:31. doi: 10.1186/1744-859X-9-31.


PMID- 20604953
OWN - NLM
STAT- MEDLINE
DCOM- 20100830
LR  - 20211020
IS  - 1476-069X (Electronic)
IS  - 1476-069X (Linking)
VI  - 9
DP  - 2010 Jul 6
TI  - Participatory testing and reporting in an environmental-justice community of
      Worcester, Massachusetts: a pilot project.
PG  - 34
LID - 10.1186/1476-069X-9-34 [doi]
AB  - BACKGROUND: Despite indoor home environments being where people spend most time, 
      involving residents in testing those environments has been very limited,
      especially in marginalized communities. We piloted participatory testing and
      reporting that combined relatively simple tests with actionable reporting to
      empower residents in Main South/Piedmont neighborhoods of Worcester,
      Massachusetts. We answered: 1) How do we design and implement the approach for
      neighborhood and household environments using participatory methods? 2) What do
      pilot tests reveal? 3) How does our experience inform testing practice? METHODS: 
      The approach was designed and implemented with community partners using
      community-based participatory research. Residents and researchers tested fourteen
      homes for: lead in dust indoors, soil outdoors, paint indoors and drinking water;
      radon in basement air; PM2.5 in indoor air; mold spores in indoor/outdoor air;
      and drinking water quality. Monitoring of neighborhood particulates by residents 
      and researchers used real-time data to stimulate dialogue. RESULTS: Given the
      newness of our partnership and unforeseen conflicts, we achieved moderate-high
      success overall based on process and outcome criteria: methods, test results,
      reporting, lessons learned. The conflict burden we experienced may be
      attributable less to generic university-community differences in
      interests/culture, and more to territoriality and interpersonal issues.
      Lead-in-paint touch-swab results were poor proxies for lead-in-dust. Of eight
      units tested in summer, three had very high lead-in-dust (>1000 microg/ft2), six 
      exceeded at least one USEPA standard for lead-in-dust and/or soil. Tap water
      tests showed no significant exposures. Monitoring of neighborhood particulates
      raised awareness of environmental health risks, especially asthma. CONCLUSIONS:
      Timely reporting back home-toxics' results to residents is ethical but it must be
      empowering. Future work should fund the active participation of a few motivated
      residents as representatives of the target population. Although difficult and
      demanding in time and effort, the approach can educate residents and inform
      exposure assessment. It should be considered as a core ingredient of
      comprehensive household toxics' testing, and has potential to improve participant
      retention and the overall positive impact of long-term environmental health
      research efforts.
FAU - Downs, Timothy J
AU  - Downs TJ
AD  - Environmental Science and Policy Program, Clark University, 950 Main Street,
      Worcester, Massachusetts 01610, USA. tdowns@clarku.edu
FAU - Ross, Laurie
AU  - Ross L
FAU - Mucciarone, Danielle
AU  - Mucciarone D
FAU - Calvache, Maria-Camila
AU  - Calvache MC
FAU - Taylor, Octavia
AU  - Taylor O
FAU - Goble, Robert
AU  - Goble R
LA  - eng
GR  - R25 ES013210/ES/NIEHS NIH HHS/United States
GR  - R25 ES013210-02/ES/NIEHS NIH HHS/United States
GR  - IR25ES013210/ES/NIEHS NIH HHS/United States
GR  - R25 ES013210-03/ES/NIEHS NIH HHS/United States
GR  - R25 ES013210-04/ES/NIEHS NIH HHS/United States
GR  - R25 ES013210-01/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20100706
PL  - England
TA  - Environ Health
JT  - Environmental health : a global access science source
JID - 101147645
RN  - 0 (Particulate Matter)
SB  - IM
MH  - Air Pollution, Indoor/analysis
MH  - Community Participation
MH  - *Community-Based Participatory Research
MH  - Environmental Exposure/*analysis
MH  - Housing
MH  - Humans
MH  - Massachusetts
MH  - Particulate Matter/analysis
MH  - Pilot Projects
PMC - PMC2914716
EDAT- 2010/07/08 06:00
MHDA- 2010/08/31 06:00
CRDT- 2010/07/08 06:00
PHST- 2010/02/09 00:00 [received]
PHST- 2010/07/06 00:00 [accepted]
PHST- 2010/07/08 06:00 [entrez]
PHST- 2010/07/08 06:00 [pubmed]
PHST- 2010/08/31 06:00 [medline]
AID - 1476-069X-9-34 [pii]
AID - 10.1186/1476-069X-9-34 [doi]
PST - epublish
SO  - Environ Health. 2010 Jul 6;9:34. doi: 10.1186/1476-069X-9-34.


PMID- 20604881
OWN - NLM
STAT- MEDLINE
DCOM- 20101101
LR  - 20210916
IS  - 1467-9566 (Electronic)
IS  - 0141-9889 (Linking)
VI  - 32
IP  - 4
DP  - 2010 May
TI  - Negotiating the contested terrain of narrative methods in illness contexts.
PG  - 647-60
LID - 10.1111/j.1467-9566.2010.01239.x [doi]
AB  - This paper offers an interpretive account of an ongoing transatlantic debate
      about illness narratives instigated by the publication in 1997 of Paul Atkinson's
      paper Narrative Turn Or Blind Alley? The claims and counter-claims to be found in
      this debate about narrative data and narrative analysis are set out sequentially,
      in an attempt to grasp the debate's essentials. Matters of theoretical
      perspective, methodology, ethics, and personal politics are found to be at stake 
      in the writings of the four featured academics: Paul Atkinson, Arthur Bochner,
      Arthur Frank and Elliot Mishler. The paper moves on to consider the types of
      sociologies at work in their arguments, and explores the debate's implications
      for the author's own illness narratives research project. The paper's overall aim
      is to assist researchers who seek to clarify their own thinking on the use of
      narrative research methods in illness contexts.
FAU - Thomas, Carol
AU  - Thomas C
AD  - Division of Health Research, School of Health and Medicine, Lancaster University,
      Lancaster LA1 4YT. c.thomas@lancaster.ac.uk
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Sociol Health Illn
JT  - Sociology of health & illness
JID - 8205036
SB  - IM
CIN - Sociol Health Illn. 2010 May;32(4):661-2. PMID: 20604882
CIN - Sociol Health Illn. 2010 May;32(4):662-5. PMID: 20604883
CIN - Sociol Health Illn. 2010 May;32(4):665-7. PMID: 20604884
MH  - Disease
MH  - Humans
MH  - *Narration
MH  - *Negotiating
MH  - *Social Medicine
EDAT- 2010/07/08 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/07/08 06:00
PHST- 2010/07/08 06:00 [entrez]
PHST- 2010/07/08 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - SHIL1239 [pii]
AID - 10.1111/j.1467-9566.2010.01239.x [doi]
PST - ppublish
SO  - Sociol Health Illn. 2010 May;32(4):647-60. doi: 10.1111/j.1467-9566.2010.01239.x.


PMID- 20604810
OWN - NLM
STAT- MEDLINE
DCOM- 20110922
LR  - 20151119
IS  - 1741-2358 (Electronic)
IS  - 0734-0664 (Linking)
VI  - 28
IP  - 2
DP  - 2011 Jun
TI  - Complete denture hygiene and nocturnal wearing habits among patients attending
      the Prosthodontic Department in a Dental University in Brazil.
PG  - 91-6
LID - 10.1111/j.1741-2358.2010.00369.x [doi]
AB  - OBJECTIVE: The aim of this study was to evaluate the overnight wearing and
      cleaning habits of complete denture wearers. BACKGROUND: Successful complete
      denture treatment can be achieved when the patients are motivated and aware of
      appropriate denture wear and hygiene. MATERIALS AND METHODS: A sample of 224
      complete denture wearers (162 women) aged 37-89 years was studied. Inclusion
      criteria comprised edentulous subjects who had received their new complete
      dentures between 2000 and 2005 in the Dental Clinic of the Aracatuba and
      Araraquara Dental School, Sao Paulo State University. Ethical approval was sought
      and granted. Subjects were interviewed using questions related to overnight
      denture wearing and denture cleaning habits. Possible statistical relationships
      among some of items were analysed by the chi-square test at 5% significance
      level. RESULTS: Of the patients, 55.8% removed their dentures during the
      overnight period and 88% did this every day. Among them, 66.4% removed both
      dentures. Most of the patients used brushing with toothpaste (105 patients -
      46.87%) as a cleaning method. More than a half of the subjects (63.4%) showed
      biofilm and calculus on their dentures. CONCLUSION: The patients need
      instructions and motivation concerning denture hygienic and denture removal
      overnight.
CI  - (c) 2010 The Gerodontology Society and John Wiley & Sons A/S.
FAU - Takamiya, Aline Satie
AU  - Takamiya AS
AD  - Department of Dental Materials and Prosthodontics, Aracatuba Dental School,
      UNESP, Sao Paulo, Brazil.
FAU - Monteiro, Douglas Roberto
AU  - Monteiro DR
FAU - Barao, Valentim Adelino Ricardo
AU  - Barao VA
FAU - Pero, Ana Carolina
AU  - Pero AC
FAU - Compagnoni, Marco Antonio
AU  - Compagnoni MA
FAU - Barbosa, Debora Barros
AU  - Barbosa DB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100628
PL  - England
TA  - Gerodontology
JT  - Gerodontology
JID - 8215850
RN  - 0 (Toothpastes)
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biofilms
MH  - Brazil
MH  - Dental Calculus/classification
MH  - Dental Restoration Wear
MH  - Denture, Complete/microbiology/*statistics & numerical data
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oral Hygiene/*statistics & numerical data
MH  - Sleep
MH  - Surveys and Questionnaires
MH  - Time Factors
MH  - Toothbrushing/statistics & numerical data
MH  - Toothpastes/therapeutic use
EDAT- 2010/07/08 06:00
MHDA- 2011/09/23 06:00
CRDT- 2010/07/08 06:00
PHST- 2010/07/08 06:00 [entrez]
PHST- 2010/07/08 06:00 [pubmed]
PHST- 2011/09/23 06:00 [medline]
AID - GER369 [pii]
AID - 10.1111/j.1741-2358.2010.00369.x [doi]
PST - ppublish
SO  - Gerodontology. 2011 Jun;28(2):91-6. doi: 10.1111/j.1741-2358.2010.00369.x. Epub
      2010 Jun 28.


PMID- 20604652
OWN - NLM
STAT- MEDLINE
DCOM- 20101014
LR  - 20191210
IS  - 1364-6893 (Electronic)
IS  - 0144-3615 (Linking)
VI  - 30
IP  - 5
DP  - 2010
TI  - Viewing ultrasound scan images prior to termination of pregnancy: choice for
      women or conflict for ultrasonographers?
PG  - 484-8
LID - 10.3109/01443615.2010.484111 [doi]
AB  - Establishing pregnancy location is key to minimising the risks of abortion, and
      establishing gestational age optimises women's choice of procedure and timing.
      There is limited information in UK practice about the views of women having an
      ultrasound before an abortion with regards to whether they would wish to see the 
      scan image of their fetus. We therefore surveyed the views of women having
      pre-abortion ultrasound scans and the views of ultrasonographers, using
      self-completed anonymous questionnaires. Responses were available for analysis
      from 191 women aged 16 to over 45. A total of 25 (13%) women had seen their scan.
      Of those who did not see their scan, 40 (24%) said they would have liked to see
      it, to aid their decision-making, as a right, or out of curiosity. Nine out of 17
      ultrasonographers completed their questionnaires. Four ultrasonographers thought 
      that women having scans before an abortion should see their scan images if they
      wished and another four thought they should not because of possible psychological
      effects. Their response also highlighted possible effects of such scans on those 
      performing them. Given the choice, a larger number of women would like to see
      their scan images than actually ask. Women request to see their pre-abortion
      ultrasound images for their own individual reasons, which should be respected.
      Ultrasonographers may have conflict or ethical dilemmas when performing
      pre-abortion scans and they should be supported in identifying women for whom
      looking at their scan images would be of benefit.
FAU - Graham, O
AU  - Graham O
AD  - Sexual and Reproductive Healthcare, City Health Care Partnership, Conifer House, 
      Hull, UK. yombo.graham@chcphull.nhs.uk
FAU - Ankrett, S
AU  - Ankrett S
FAU - Killick, S R
AU  - Killick SR
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Obstet Gynaecol
JT  - Journal of obstetrics and gynaecology : the journal of the Institute of
      Obstetrics and Gynaecology
JID - 8309140
SB  - IM
MH  - Abortion, Induced/*psychology
MH  - Adolescent
MH  - Adult
MH  - Allied Health Personnel/psychology
MH  - *Attitude of Health Personnel
MH  - *Choice Behavior
MH  - *Conflict, Psychological
MH  - Decision Making
MH  - Female
MH  - Humans
MH  - Patient Preference
MH  - Pregnancy
MH  - Surveys and Questionnaires
MH  - Ultrasonography, Prenatal/*psychology
MH  - Young Adult
EDAT- 2010/07/08 06:00
MHDA- 2010/10/15 06:00
CRDT- 2010/07/08 06:00
PHST- 2010/07/08 06:00 [entrez]
PHST- 2010/07/08 06:00 [pubmed]
PHST- 2010/10/15 06:00 [medline]
AID - 10.3109/01443615.2010.484111 [doi]
PST - ppublish
SO  - J Obstet Gynaecol. 2010;30(5):484-8. doi: 10.3109/01443615.2010.484111.


PMID- 20604594
OWN - NLM
STAT- MEDLINE
DCOM- 20101019
LR  - 20100707
IS  - 1939-1854 (Electronic)
IS  - 0021-9010 (Linking)
VI  - 95
IP  - 4
DP  - 2010 Jul
TI  - Automatic ethics: the effects of implicit assumptions and contextual cues on
      moral behavior.
PG  - 752-60
LID - 10.1037/a0019411 [doi]
AB  - We empirically examine the reflexive or automatic aspects of moral decision
      making. To begin, we develop and validate a measure of an individual's implicit
      assumption regarding the inherent morality of business. Then, using an in-basket 
      exercise, we demonstrate that an implicit assumption that business is inherently 
      moral impacts day-to-day business decisions and interacts with contextual cues to
      shape moral behavior. Ultimately, we offer evidence supporting a characterization
      of employees as reflexive interactionists: moral agents whose automatic
      decision-making processes interact with the environment to shape their moral
      behavior.
FAU - Reynolds, Scott J
AU  - Reynolds SJ
AD  - Michael G. Foster School of Business, University of Washington, Seattle, WA
      98028, USA. heyscott@u.washington.edu
FAU - Leavitt, Keith
AU  - Leavitt K
FAU - DeCelles, Katherine A
AU  - DeCelles KA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Appl Psychol
JT  - The Journal of applied psychology
JID - 0222526
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Cues
MH  - Culture
MH  - *Ethics
MH  - Ethics, Business
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Morals
MH  - Social Behavior
MH  - Social Perception
MH  - Young Adult
EDAT- 2010/07/08 06:00
MHDA- 2010/10/20 06:00
CRDT- 2010/07/08 06:00
PHST- 2010/07/08 06:00 [entrez]
PHST- 2010/07/08 06:00 [pubmed]
PHST- 2010/10/20 06:00 [medline]
AID - 2010-13313-011 [pii]
AID - 10.1037/a0019411 [doi]
PST - ppublish
SO  - J Appl Psychol. 2010 Jul;95(4):752-60. doi: 10.1037/a0019411.


PMID- 20603309
OWN - NLM
STAT- MEDLINE
DCOM- 20101101
LR  - 20100706
IS  - 1461-7196 (Electronic)
IS  - 1363-4593 (Linking)
VI  - 14
IP  - 4
DP  - 2010 Jul
TI  - Struggles online over the meaning of 'Down's syndrome': A 'dialogic'
      interpretation.
PG  - 398-414
LID - 10.1177/1363459309358598 [doi]
AB  - Bakhtin's suggestion that a unified truth demands a 'multiplicity of
      consciousnesses' seems particularly relevant in the 'globally connected age'. At 
      a time when the DIY/'punk ethic' seems to prevail online, and Wikipedia and
      blogging means that anyone with access to the Internet can enter into public
      deliberation, it is worth considering the potential for mass communication
      systems to create meaningful changes in the way that 'disability' is theorized.
      Based on the findings of qualitative research, this study explores competing
      interpretations of disability, specifically dialogue online over the meaning of
      Down's syndrome, from the vantage point of an approach towards language analysis 
      that emanates from the work of the Bakhtin Circle. It will be shown that,
      suitably revised and supplemented, elements of Bakhtinian theory provide powerful
      tools for understanding online relations and changes in the notion of disability.
      It will also be shown that, while activists in the disabled people's movement
      have managed to effect modest changes to the way that disability is theorized,
      both online and in the 'real world', there remains a great deal still to be
      achieved. This study allows us to understand better the social struggles faced by
      disabled people and the opportunities open to them.
FAU - Cimini, Nicholas
AU  - Cimini N
AD  - University of Sheffield, UK. nicholascimini@gmail.com
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Health (London)
JT  - Health (London, England : 1997)
JID - 9800465
SB  - IM
MH  - *Disability Evaluation
MH  - Disabled Persons
MH  - *Down Syndrome
MH  - Humans
MH  - *Internet
MH  - Language
MH  - Terminology as Topic
EDAT- 2010/07/07 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/07/07 06:00
PHST- 2010/07/07 06:00 [entrez]
PHST- 2010/07/07 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - 14/4/398 [pii]
AID - 10.1177/1363459309358598 [doi]
PST - ppublish
SO  - Health (London). 2010 Jul;14(4):398-414. doi: 10.1177/1363459309358598.


PMID- 20603308
OWN - NLM
STAT- MEDLINE
DCOM- 20101101
LR  - 20100706
IS  - 1461-7196 (Electronic)
IS  - 1363-4593 (Linking)
VI  - 14
IP  - 4
DP  - 2010 Jul
TI  - Genetic counselling as care of the self.
PG  - 383-97
LID - 10.1177/1363459309360791 [doi]
AB  - Genetic counselling has frequently been described as a disciplinary practice,
      with the goal of 'risk reduction'. In this article another dimension to genetic
      counselling is considered through the Foucauldian theorization on the care of the
      self. Drawing on narrative analysis, I examine how one informant undergoing
      genetic counselling interprets the technique of imagining alternative futures
      learned through counselling, and transforms it into an ethical practice of
      self-care. The findings suggest that what may begin as a medical issue with
      implications for one's health, becomes a meditation over one's disposition
      towards life, in a way that is consonant with one's desires and values.
FAU - Leontini, Rose
AU  - Leontini R
AD  - University of Sydney, Australia. R.Leontini@usyd.edu.au
LA  - eng
PT  - Journal Article
PL  - England
TA  - Health (London)
JT  - Health (London, England : 1997)
JID - 9800465
SB  - IM
MH  - Adult
MH  - Female
MH  - Genetic Counseling/*ethics
MH  - Humans
MH  - Huntington Disease
MH  - Interviews as Topic
MH  - Male
MH  - Middle Aged
MH  - *Self Care
EDAT- 2010/07/07 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/07/07 06:00
PHST- 2010/07/07 06:00 [entrez]
PHST- 2010/07/07 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - 14/4/383 [pii]
AID - 10.1177/1363459309360791 [doi]
PST - ppublish
SO  - Health (London). 2010 Jul;14(4):383-97. doi: 10.1177/1363459309360791.


PMID- 20602709
OWN - NLM
STAT- MEDLINE
DCOM- 20110307
LR  - 20100706
IS  - 1440-1800 (Electronic)
IS  - 1320-7881 (Linking)
VI  - 17
IP  - 2
DP  - 2010 Jun
TI  - A discourse analysis comparing Danish textbooks for nursing and medical students 
      between 1870 and 1956.
PG  - 151-64
LID - 10.1111/j.1440-1800.2010.00487.x [doi]
AB  - Based on a discourse analysis inspired by the French philosopher Michel
      Foucault's late work, the article compares Danish textbooks for nurses and
      doctors between 1870 and 1956. With the concept of a figure of thought, it is
      suggested that the discourses of knowledge addressed to nurses were constructed
      in a pattern in which intertwined arguments formed the figure of orderliness.
      These arguments were based on knowledge, the patient's needs, the doctor's needs 
      and moral principles, including the needs of the profession and ethical-esthetic 
      principles, whereas the pattern of the discourses of knowledge addressed to the
      doctor was based on knowledge of diseases reflecting a figure of scientific
      order. These patterns did not change throughout the period. In the textbooks for 
      nurses, the nurse's relation to self was an explicit subject, whereas the
      doctor's relation to self was not part of the textbooks addressed to doctors. In 
      light of Foucault's late work, it is suggested that the discourses of knowledge
      contribute to maintaining the prevailing order in the society; it would be of
      interest to investigate whether the identified pattern has changed since 1956 and
      whether it has influenced other areas of nursing education and practice.
FAU - Frederiksen, Kirsten
AU  - Frederiksen K
AD  - University of Aarhus, Aarhus, Denmark. kirsten.frederiksen@sygeplejevid.au.dk
LA  - eng
PT  - Comparative Study
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Nurs Inq
JT  - Nursing inquiry
JID - 9505881
MH  - Denmark
MH  - Education, Medical/*history
MH  - Education, Nursing/*history
MH  - *Health Knowledge, Attitudes, Practice
MH  - History of Nursing
MH  - History, 19th Century
MH  - History, 20th Century
MH  - Humans
MH  - Philosophy, Medical
MH  - Philosophy, Nursing
MH  - Physician-Nurse Relations
MH  - Students, Medical/*history
MH  - Students, Nursing/*history
MH  - Textbooks as Topic/*history
EDAT- 2010/07/07 06:00
MHDA- 2011/03/08 06:00
CRDT- 2010/07/07 06:00
PHST- 2010/07/07 06:00 [entrez]
PHST- 2010/07/07 06:00 [pubmed]
PHST- 2011/03/08 06:00 [medline]
AID - NIN487 [pii]
AID - 10.1111/j.1440-1800.2010.00487.x [doi]
PST - ppublish
SO  - Nurs Inq. 2010 Jun;17(2):151-64. doi: 10.1111/j.1440-1800.2010.00487.x.


PMID- 20602686
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20151119
IS  - 1442-2018 (Electronic)
IS  - 1441-0745 (Linking)
VI  - 12
IP  - 2
DP  - 2010 Jun
TI  - Influence of marital and educational status on clients' psychosocial adjustment
      to HIV/AIDS in Calabar, Nigeria.
PG  - 155-61
LID - 10.1111/j.1442-2018.2009.00510.x [doi]
AB  - A comparative descriptive design and a stratified random sampling technique were 
      adopted to study the influence of marital and educational status on the
      psychological, social, and spiritual adjustment of 280 respondents living with
      HIV/AIDS in two randomly selected clinics within Calabar, Nigeria. A 30 item
      questionnaire, with a content validity index of 0.92 and a Cronbach's alpha
      reliability coefficient of 0.94, was used for data collection, with due attention
      to ethical considerations. The findings showed that marital status had a
      significant influence on the respondents' psychological and social adjustment but
      not on their spiritual adjustment. Those that were married and those with higher 
      educational qualifications had better psychological adjustment than those who had
      never married. The marital and educational status of clients should be considered
      when conducting education or counseling, making recommendations, or organizing
      support groups for living with HIV/AIDS. Furthermore, advocacy aimed at meeting
      the psychosocial needs of single and less-educated clients could enhance their
      psychosocial adjustment.
FAU - Akpabio, Idongesit I
AU  - Akpabio II
AD  - Departments of Nursing Science, College of Medical Sciences, University of
      Calabar, Nigeria. idongawa@yahoo.com
FAU - Uyanah, David A
AU  - Uyanah DA
FAU - Osuchukwu, Nelson C
AU  - Osuchukwu NC
FAU - Samson-Akpan, Patience E
AU  - Samson-Akpan PE
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Australia
TA  - Nurs Health Sci
JT  - Nursing & health sciences
JID - 100891857
SB  - IM
MH  - *Adaptation, Psychological
MH  - Adolescent
MH  - Adult
MH  - Analysis of Variance
MH  - *Community Health Nursing
MH  - Educational Status
MH  - Female
MH  - HIV Infections/nursing/*psychology
MH  - Humans
MH  - Male
MH  - Marital Status/*statistics & numerical data
MH  - Middle Aged
MH  - Nigeria
MH  - Prejudice
MH  - Self-Help Groups
MH  - Spirituality
MH  - *Stress, Psychological
MH  - Surveys and Questionnaires
EDAT- 2010/07/07 06:00
MHDA- 2011/01/07 06:00
CRDT- 2010/07/07 06:00
PHST- 2010/07/07 06:00 [entrez]
PHST- 2010/07/07 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
AID - NHS510 [pii]
AID - 10.1111/j.1442-2018.2009.00510.x [doi]
PST - ppublish
SO  - Nurs Health Sci. 2010 Jun;12(2):155-61. doi: 10.1111/j.1442-2018.2009.00510.x.


PMID- 20602541
OWN - NLM
STAT- MEDLINE
DCOM- 20100826
LR  - 20191210
IS  - 0261-1929 (Print)
IS  - 0261-1929 (Linking)
VI  - 38
IP  - 3
DP  - 2010 Jun
TI  - Validating animal models for preclinical research: a scientific and ethical
      discussion.
PG  - 245-8
AB  - The use of animals to model humans in biomedical research relies on the notion
      that basic processes are sufficiently similar across species to allow
      extrapolation. Animal model validity is discussed in terms of the similarity
      between the model and the human condition it is intended to model, but no formal 
      validation of models is applied. There is a stark contrast here with the use of
      non-animal alternatives in toxicology and safety studies, for which an extensive 
      validation is required. We discuss both the potential and the limitations of
      validating preclinical animal models for proof-of-concept studies, by using an
      approach similar to that applied to alternative non-animal methods in toxicology 
      and safety testing. A major challenge in devising a validation system for animal 
      models is the lack of a clear gold standard with which to compare results. While 
      a complete adoption of the validation approach for alternative methods is
      probably inappropriate for research animal models, key features, such as making
      data available for external validation and defining a strategy to run experiments
      in a way that permits meaningful retrospective analysis, remain highly relevant.
FAU - Varga, Orsolya E
AU  - Varga OE
AD  - Laboratory Animal Science, Institute for Molecular and Cell Biology (IBMC),
      University of Porto, Porto, Portugal. ovarga@ibmc.up.pt
FAU - Hansen, Axel K
AU  - Hansen AK
FAU - Sandoe, Peter
AU  - Sandoe P
FAU - Olsson, I Anna S
AU  - Olsson IA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
PL  - England
TA  - Altern Lab Anim
JT  - Alternatives to laboratory animals : ATLA
JID - 8110074
SB  - IM
MH  - Animal Welfare/*ethics
MH  - Animals
MH  - *Animals, Laboratory
MH  - *Bioethical Issues
MH  - Drug Evaluation, Preclinical/*ethics/methods
MH  - Humans
MH  - *Models, Animal
MH  - Research Design
MH  - Species Specificity
EDAT- 2010/07/07 06:00
MHDA- 2010/08/27 06:00
CRDT- 2010/07/07 06:00
PHST- 2010/07/07 06:00 [entrez]
PHST- 2010/07/07 06:00 [pubmed]
PHST- 2010/08/27 06:00 [medline]
AID - 10.1177/026119291003800309 [doi]
PST - ppublish
SO  - Altern Lab Anim. 2010 Jun;38(3):245-8. doi: 10.1177/026119291003800309.


PMID- 20602540
OWN - NLM
STAT- MEDLINE
DCOM- 20100826
LR  - 20190518
IS  - 0261-1929 (Print)
IS  - 0261-1929 (Linking)
VI  - 38
IP  - 3
DP  - 2010 Jun
TI  - Refining animal experiments: the first Brazilian regulation on animal
      experimentation.
PG  - 239-44
AB  - The very first law on animal experimentation has been approved recently in
      Brazil, and now is part of a set of the legal instruments that profile the
      Brazilian government's attitude toward the use of animals in experiments. Law
      11794/08 establishes a new legal instrument that will guide new methods of
      conduct for ethics committees, researchers and representatives of animal
      protection societies. This comment aims to analyse critically the implications
      that this law brings to Brazilian reality. The link between it and the Russell
      and Burch's Three Rs concept is defined, and certain problems are identified. The
      conclusion is that the body of the law emphasises the refinement of animal
      experiments, but gives little importance to the principles of reduction and
      replacement.
FAU - de A e Trez, Thales
AU  - de A e Trez T
AD  - Department of Human Sciences, Universidade Federal de Alfenas, Alfenas, MG,
      Brazil. thales@unifal-mg.edu.br
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Altern Lab Anim
JT  - Alternatives to laboratory animals : ATLA
JID - 8110074
SB  - IM
MH  - Animal Experimentation/*legislation & jurisprudence
MH  - Animal Testing Alternatives/*legislation & jurisprudence
MH  - Animal Welfare/*legislation & jurisprudence
MH  - Animals
MH  - Animals, Laboratory
MH  - Brazil
MH  - Models, Animal
EDAT- 2010/07/07 06:00
MHDA- 2010/08/27 06:00
CRDT- 2010/07/07 06:00
PHST- 2010/07/07 06:00 [entrez]
PHST- 2010/07/07 06:00 [pubmed]
PHST- 2010/08/27 06:00 [medline]
AID - 10.1177/026119291003800308 [doi]
PST - ppublish
SO  - Altern Lab Anim. 2010 Jun;38(3):239-44. doi: 10.1177/026119291003800308.


PMID- 20602538
OWN - NLM
STAT- MEDLINE
DCOM- 20100826
LR  - 20190518
IS  - 0261-1929 (Print)
IS  - 0261-1929 (Linking)
VI  - 38
IP  - 3
DP  - 2010 Jun
TI  - The current status of animal use and alternatives in Korean veterinary medical
      schools.
PG  - 221-30
AB  - Two new Korean laws regulating animal welfare and the humane use of animals in
      science came into effect in 2008 and 2009. Both these laws impose ethical
      committee review prior to the performance of animal experiments in research,
      testing and education. This study briefly summarises the new Korean laws, and
      investigates the current status regarding the numbers of animals used, the
      alternatives to animals which are used, the curricula relating to the humane use 
      of animals, and ethical review practices in Korean veterinary education.
      Approximately 4,845 animals, representing 20 different species, were used in
      veterinary medical education in Korea in 2007. Korea has begun to introduce
      formal courses on animal welfare for the humane treatment of animals used in
      experiments, and an ethical protocol review system prior to animal use in
      education. Korea is moving toward better animal welfare, by incorporating
      practices consistent with international standards. The information presented
      represents the first such data gathered in Korea, which should prove useful for
      monitoring the implementation of replacement, reduction, and refinement measures 
      in animal use for education purposes.
FAU - Lee, Gwi Hyang
AU  - Lee GH
AD  - The Institute for the 3Rs, College of Veterinary Medicine, Konkuk University,
      Seoul, Korea.
FAU - Choe, Byung In
AU  - Choe BI
FAU - Kim, Jin Suk
AU  - Kim JS
FAU - Hart, Lynette A
AU  - Hart LA
FAU - Han, Jin Soo
AU  - Han JS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Altern Lab Anim
JT  - Alternatives to laboratory animals : ATLA
JID - 8110074
SB  - IM
MH  - Animal Experimentation/ethics/*legislation & jurisprudence/statistics & numerical
      data
MH  - Animal Use Alternatives/*legislation & jurisprudence/statistics & numerical
      data/trends
MH  - Animals
MH  - *Animals, Laboratory
MH  - Education, Veterinary/ethics/*legislation & jurisprudence/statistics & numerical 
      data
MH  - Republic of Korea
MH  - *Schools, Veterinary
EDAT- 2010/07/07 06:00
MHDA- 2010/08/27 06:00
CRDT- 2010/07/07 06:00
PHST- 2010/07/07 06:00 [entrez]
PHST- 2010/07/07 06:00 [pubmed]
PHST- 2010/08/27 06:00 [medline]
AID - 10.1177/026119291003800305 [doi]
PST - ppublish
SO  - Altern Lab Anim. 2010 Jun;38(3):221-30. doi: 10.1177/026119291003800305.


PMID- 20602536
OWN - NLM
STAT- MEDLINE
DCOM- 20100826
LR  - 20190518
IS  - 0261-1929 (Print)
IS  - 0261-1929 (Linking)
VI  - 38
IP  - 3
DP  - 2010 Jun
TI  - The extended welfare assessment grid: a matrix for the assessment of welfare and 
      cumulative suffering in experimental animals.
PG  - 205-12
AB  - Combining a range of assessment parameters into one usable entity has been
      identified as an important goal in providing a practical, objective and robust
      assessment of welfare, particularly in laboratory animals. This paper refines and
      extends one such previously published method. The proposed Extended Welfare
      Assessment Grid provides for the incorporation of changes in the state of an
      animal over time, allowing for predictive, retrospective, scheduled, or event
      monitoring. It enables the numeric, as well as visual, representation of the
      animal's welfare, placing this in the context of the careful and realistic
      justification for experimental use of the animal. This assessment method
      represents a valuable tool for those tasked with ensuring ethical oversight, as
      well as for those planning the use, or monitoring, of animals in research. It is 
      particularly applicable to animals used in long-term studies, especially
      non-human primates. It is believed that this system will draw attention to the
      temporal component of suffering that is often overlooked in the planning of
      research schedules and allow an assessment of cumulative suffering imposed by the
      events that occur.
FAU - Honess, Paul
AU  - Honess P
AD  - Department of Veterinary Services, University of Oxford, Oxford, UK.
      paul.honess@vet.ox.ac.uk
FAU - Wolfensohn, Sarah
AU  - Wolfensohn S
LA  - eng
PT  - Journal Article
PL  - England
TA  - Altern Lab Anim
JT  - Alternatives to laboratory animals : ATLA
JID - 8110074
SB  - IM
MH  - Animal Experimentation/*ethics
MH  - Animal Husbandry/standards
MH  - Animal Welfare/*ethics
MH  - Animals
MH  - Animals, Laboratory
MH  - Research Design
MH  - Stress, Psychological
EDAT- 2010/07/07 06:00
MHDA- 2010/08/27 06:00
CRDT- 2010/07/07 06:00
PHST- 2010/07/07 06:00 [entrez]
PHST- 2010/07/07 06:00 [pubmed]
PHST- 2010/08/27 06:00 [medline]
AID - 10.1177/026119291003800304 [doi]
PST - ppublish
SO  - Altern Lab Anim. 2010 Jun;38(3):205-12. doi: 10.1177/026119291003800304.


PMID- 20602296
OWN - NLM
STAT- MEDLINE
DCOM- 20110218
LR  - 20131121
IS  - 1439-3999 (Electronic)
IS  - 0023-2165 (Linking)
VI  - 227
IP  - 9
DP  - 2010 Sep
TI  - [Collagen cross-linking with riboflavin and UVA light].
PG  - 723-8
LID - 10.1055/s-0029-1245327 [doi]
AB  - PURPOSE: Since 1998 collagen cross-linking is used for patients with progressive 
      keratoconus. Today it can almost be considered as the standard therapy. METHODS: 
      Patients with progressive keratoconus and minimal corneal thickness of 400 microm
      have been cross-linked within a study - (EK 310 499) approved by the ethical
      committee since 1998. An increase of the maximum K-value by >/= 1 D within the
      last year, patient's statement of deteriorating visual acuity or the necessity of
      new contact len fitting more than once in 2 years were considered as progression.
      RESULTS: The analysis includes 153 eyes of 111 patients with a minimal follow-up 
      of 12 months and a maximum follow-up of 6 years. The keratectasia significantly
      decreased in the 1 (st) year by 2.28 D. The visual acuity improved significantly 
      by at least one line or, respectively, remained stable (i. e., no line loss) in
      the 1st year in 73 %. The results remained stable over the next two years.
      Despite the low number of patients with a follow-up longer than 3 years and
      therefore limited statistical statement power, our results still indicate a
      long-term stabilisation or, respectively, improvement after collagen
      cross-linking. We saw no severe side-effects. Three patients with an exacerbated 
      neurodermitis showed continuous progression of keratoconus and were cross-linked 
      again. CONCLUSIONS: To date there have been numerous promising publications on
      collagen cross-linking for keratoconus. The results of this study indicate that
      collagen cross-linking appears to be an effective therapeutic option for
      progressing keratoconus. Besides the clinical there are enormous economical and
      psychosocial benefits. Cross-linking is an out-patient, minimally-invasive,
      cost-effective treatment with minimal strain for the persons concerned.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Hoyer, A
AU  - Hoyer A
AD  - Augenklinik, Elblandklinikum Radebeul. Anne.Hoyer@elblandkliniken.de
FAU - Sporl, E
AU  - Sporl E
FAU - Pillunat, L E
AU  - Pillunat LE
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Kollagenvernetzung mit Riboflavin und UVA-Licht.
DEP - 20100702
PL  - Germany
TA  - Klin Monbl Augenheilkd
JT  - Klinische Monatsblatter fur Augenheilkunde
JID - 0014133
RN  - 0 (Cross-Linking Reagents)
RN  - 9007-34-5 (Collagen)
RN  - TLM2976OFR (Riboflavin)
SB  - IM
MH  - Adult
MH  - Ambulatory Care
MH  - Collagen/*metabolism
MH  - Combined Modality Therapy
MH  - Corneal Stroma/drug effects/pathology
MH  - Cross-Linking Reagents/*administration & dosage
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Keratoconus/diagnosis/*drug therapy/etiology/pathology
MH  - Male
MH  - Riboflavin/*administration & dosage
MH  - *Ultraviolet Therapy
MH  - Visual Acuity/drug effects
EDAT- 2010/07/06 06:00
MHDA- 2011/02/22 06:00
CRDT- 2010/07/06 06:00
PHST- 2010/07/06 06:00 [entrez]
PHST- 2010/07/06 06:00 [pubmed]
PHST- 2011/02/22 06:00 [medline]
AID - 10.1055/s-0029-1245327 [doi]
PST - ppublish
SO  - Klin Monbl Augenheilkd. 2010 Sep;227(9):723-8. doi: 10.1055/s-0029-1245327. Epub 
      2010 Jul 2.


PMID- 20601793
OWN - NLM
STAT- MEDLINE
DCOM- 20101007
LR  - 20220330
IS  - 1972-2680 (Electronic)
IS  - 1972-2680 (Linking)
VI  - 4
IP  - 6
DP  - 2010 Jun 30
TI  - Hepatitis B virus infections in apparently healthy urban Nigerians: data from
      pre-vaccination tests.
PG  - 397-400
AB  - BACKGROUND: In spite of the availability of an effective vaccine since 1982
      against hepatitis B, infection with hepatitis B virus (HBV), which is 50 to 100
      times more infectious than HIV, still persists in most parts of the world with
      Nigeria being described as an endemic zone. We therefore set out to establish the
      prevalence of this infection and evaluate its relationship with age and gender in
      urban Nigerians. METHODOLOGY: During pre-vaccination tests, blood samples were
      collected by finger-prick and venepuncture from 1,891 subjects aged < or = 60
      years, between 2008 and 2009 after having obtained informed consent and ethical
      clearance. Smart Check HBsAg (Globalemed, Cape Town, South Africa) and
      ShantestTM-HBsAg Elisa (Shantha Biotechnics Ltd, Hyderabad, India) were used for 
      initial and confirmatory tests respectively. RESULTS: Of the 1,891 participants, 
      957 (50.6 %) were males and 934 (49.4%) were females. Overall 114 (6.0%) were
      positive, of whom 71 (7.4%) were males and 43 (4.6%) females. Those aged 21-30
      years had the highest infection rate, and males were more likely to be infected
      with the virus than females (P > 0.05). CONCLUSIONS: Such a high prevalence of a 
      vaccine-preventable infection questions the effectiveness of the Nigerian
      vaccination strategies. The Nigerian government hepatitis B vaccination
      programme, which hitherto is limited to the National Childhood Immunisation
      Programme, should include the adult population.
FAU - Adoga, Moses P
AU  - Adoga MP
AD  - Virology Department, Innovative Biotech Ltd, Keffi, Nasarawa State, Nigeria.
FAU - Gyar, Silas D
AU  - Gyar SD
FAU - Pechulano, Simon
AU  - Pechulano S
FAU - Bashayi, Obadiah D
AU  - Bashayi OD
FAU - Emiasegen, Samuel E
AU  - Emiasegen SE
FAU - Zungwe, Timothy
AU  - Zungwe T
FAU - Iperepolu, Odunayo H
AU  - Iperepolu OH
FAU - Agupugo, Chinwe
AU  - Agupugo C
FAU - Agwale, Simon M
AU  - Agwale SM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100630
PL  - Italy
TA  - J Infect Dev Ctries
JT  - Journal of infection in developing countries
JID - 101305410
RN  - 0 (Hepatitis B Surface Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Hepatitis B/*epidemiology
MH  - Hepatitis B Surface Antigens/blood
MH  - Hepatitis B virus/*isolation & purification
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nigeria/epidemiology
MH  - Prevalence
MH  - Risk Factors
MH  - Urban Population
MH  - Young Adult
EDAT- 2010/07/06 06:00
MHDA- 2010/10/12 06:00
CRDT- 2010/07/06 06:00
PHST- 2009/10/18 00:00 [received]
PHST- 2010/01/31 00:00 [accepted]
PHST- 2010/04/26 00:00 [revised]
PHST- 2010/07/06 06:00 [entrez]
PHST- 2010/07/06 06:00 [pubmed]
PHST- 2010/10/12 06:00 [medline]
PST - epublish
SO  - J Infect Dev Ctries. 2010 Jun 30;4(6):397-400.


PMID- 20599423
OWN - NLM
STAT- MEDLINE
DCOM- 20100903
LR  - 20220408
IS  - 1474-5488 (Electronic)
IS  - 1470-2045 (Linking)
VI  - 11
IP  - 8
DP  - 2010 Aug
TI  - Cancer diagnosis in people with severe mental illness: practical and ethical
      issues.
PG  - 797-804
LID - 10.1016/S1470-2045(10)70085-1 [doi]
AB  - There has been increasing recognition of the high physical morbidity in patients 
      with severe mental illness, but little has been written about cancer in these
      patients. Therefore, we review the published work on risk of cancer in patients
      with severe mental illness, treatment challenges, and ethical issues. Severe
      mental illness is associated with behaviours that predispose an individual to an 
      increased risk of some cancers, including lung and breast cancer, although lower 
      rates of other cancers are reported in this population. Severe mental illness is 
      also associated with disparities in screening for cancer and with higher
      case-fatality rates. This higher rate is partly due to the specific challenges of
      treating these patients, including medical comorbidity, drug interactions, lack
      of capacity, and difficulties in coping with the treatment regimen as a result of
      psychiatric symptoms. To ensure that patients with severe mental illness receive 
      effective treatment, inequalities in care need to be addressed by all health-care
      professionals involved, including those from mental health services and the
      surgical and oncology teams.
CI  - 2010 Elsevier Ltd. All rights reserved.
FAU - Howard, Louise M
AU  - Howard LM
AD  - Health Service and Population Research Department, Institute of Psychiatry,
      King's College London, London, UK. louise.howard@kcl.ac.uk
FAU - Barley, Elizabeth A
AU  - Barley EA
FAU - Davies, Elizabeth
AU  - Davies E
FAU - Rigg, Anne
AU  - Rigg A
FAU - Lempp, Heidi
AU  - Lempp H
FAU - Rose, Diana
AU  - Rose D
FAU - Taylor, David
AU  - Taylor D
FAU - Thornicroft, Graham
AU  - Thornicroft G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100703
PL  - England
TA  - Lancet Oncol
JT  - The Lancet. Oncology
JID - 100957246
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Psychotropic Drugs)
SB  - IM
MH  - Antineoplastic Agents/adverse effects
MH  - Bipolar Disorder/drug therapy/epidemiology
MH  - Comorbidity
MH  - Drug Interactions
MH  - Health Services Accessibility
MH  - Health Status Disparities
MH  - Humans
MH  - Mass Screening/statistics & numerical data
MH  - Mental Competency
MH  - Mental Disorders/*drug therapy/*epidemiology
MH  - Neoplasms/*epidemiology/*therapy
MH  - Psychotic Disorders/drug therapy/epidemiology
MH  - Psychotropic Drugs/adverse effects
MH  - Schizophrenia/drug therapy/epidemiology
RF  - 79
EDAT- 2010/07/06 06:00
MHDA- 2010/09/04 06:00
CRDT- 2010/07/06 06:00
PHST- 2010/07/06 06:00 [entrez]
PHST- 2010/07/06 06:00 [pubmed]
PHST- 2010/09/04 06:00 [medline]
AID - S1470-2045(10)70085-1 [pii]
AID - 10.1016/S1470-2045(10)70085-1 [doi]
PST - ppublish
SO  - Lancet Oncol. 2010 Aug;11(8):797-804. doi: 10.1016/S1470-2045(10)70085-1. Epub
      2010 Jul 3.


PMID- 20599295
OWN - NLM
STAT- MEDLINE
DCOM- 20101013
LR  - 20220321
IS  - 1097-6787 (Electronic)
IS  - 0190-9622 (Linking)
VI  - 63
IP  - 4
DP  - 2010 Oct
TI  - The integrity of the dermatology National Resident Matching Program: results of a
      national study.
PG  - 594-601
LID - 10.1016/j.jaad.2009.11.009 [doi]
AB  - BACKGROUND: National Resident Matching Program (NRMP) policy outlines the conduct
      expected by both program directors and residency applicants. However, recent
      studies and personal experiences have introduced the possibility that NRMP policy
      is violated during the residency application process. OBJECTIVE: To investigate
      the communications that occur between dermatology applicants and dermatology
      programs during the residency application process. METHODS: From April to July
      2009, we surveyed 2009 Stanford dermatology applicants, current US dermatology
      residents, and US dermatology program directors. The survey was anonymous and
      available online. The main outcome measures were the frequency and incidence of
      dermatology NRMP policy violations. RESULTS: Thirty-one percent of Stanford
      applicants and 19% of US dermatology residents felt pressured to reveal to
      programs how they ranked them before match day. Seventeen percent of Stanford
      applicants and 14% of US dermatology residents witnessed behavior that made them 
      feel uncomfortable or that they thought was a possible ethical infraction of NRMP
      policy. LIMITATIONS: Response rates were as follows: 43% of Stanford applicants, 
      46% of residents, and 61% of program directors. CONCLUSIONS: Our data suggest
      that some dermatology program directors violate NRMP policy during their
      communications with applicants. The most widespread violation is pressuring
      applicants into revealing how they intend to rank programs. Other violations
      include apparent sexual discrimination and reserving NRMP positions for
      preselected applicants. Additional studies should be done in order to determine
      the incidence of dermatology applicants violating NRMP policy.
CI  - Copyright (c) 2010 American Academy of Dermatology, Inc. Published by Mosby, Inc.
      All rights reserved.
FAU - Sbicca, Jennifer A
AU  - Sbicca JA
AD  - University of Florida College of Medicine, Gainesville, Florida, USA.
FAU - Gorell, Emily S
AU  - Gorell ES
FAU - Kanzler, Matthew H
AU  - Kanzler MH
FAU - Lane, Alfred T
AU  - Lane AT
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Am Acad Dermatol
JT  - Journal of the American Academy of Dermatology
JID - 7907132
SB  - IM
MH  - Adult
MH  - Career Choice
MH  - Cross-Sectional Studies
MH  - Dermatology/*education/ethics
MH  - Ethics, Professional
MH  - Faculty, Medical/organization & administration
MH  - Female
MH  - Humans
MH  - Internship and Residency/ethics/*organization & administration
MH  - *Leadership
MH  - Male
MH  - Personnel Selection/*ethics
MH  - Program Evaluation
MH  - Quality Control
MH  - Surveys and Questionnaires
MH  - United States
EDAT- 2010/07/06 06:00
MHDA- 2010/10/14 06:00
CRDT- 2010/07/06 06:00
PHST- 2009/09/03 00:00 [received]
PHST- 2009/10/27 00:00 [revised]
PHST- 2009/11/02 00:00 [accepted]
PHST- 2010/07/06 06:00 [entrez]
PHST- 2010/07/06 06:00 [pubmed]
PHST- 2010/10/14 06:00 [medline]
AID - S0190-9622(09)01444-3 [pii]
AID - 10.1016/j.jaad.2009.11.009 [doi]
PST - ppublish
SO  - J Am Acad Dermatol. 2010 Oct;63(4):594-601. doi: 10.1016/j.jaad.2009.11.009.


PMID- 20599055
OWN - NLM
STAT- MEDLINE
DCOM- 20100723
LR  - 20191210
IS  - 1532-821X (Electronic)
IS  - 0003-9993 (Linking)
VI  - 91
IP  - 7
DP  - 2010 Jul
TI  - Rehabilitation of the elbow extension with motor imagery in a patient with
      quadriplegia after tendon transfer.
PG  - 1143-6
LID - 10.1016/j.apmr.2010.04.011 [doi]
AB  - OBJECTIVE: To test the effect of a postsurgical motor imagery program in the
      rehabilitation of a patient with quadriplegia. DESIGN: Crossover design with
      kinematic analysis. SETTING: Rehabilitation Hospital of Lyon. Study approved by
      the local Human Research Ethics Committee. PARTICIPANTS: C6-level injured patient
      (American Spinal Injury Association Impairment Scale grade A) with no voluntary
      elbow extension (triceps brachialis score 1). INTERVENTION: The surgical
      procedure was to transfer the distal insertion of the biceps brachii onto the
      triceps tendon of both arms. The postsurgical intervention on the left arm
      included 10 sessions of physical rehabilitation followed by 10 motor imagery
      sessions of 30 minutes each. The patient underwent 5 sessions a week during 2
      consecutive weeks. The motor imagery content included mental representations
      based on elbow extension involved in goal-directed movements. The rehabilitation 
      period of the right arm was reversed, with motor imagery performed first,
      followed by physical therapy. MAIN OUTCOME MEASURES: The kinematics of upper-limb
      movements was recorded (movement time and variability) before and after each type
      of rehabilitation period. A long-term retention test was performed 1 month later.
      RESULTS: Motor imagery training enhanced motor recovery by reducing hand
      trajectory variability-that is, improving smoothness. Motor performance then
      remained stable over 1 month. CONCLUSIONS: Motor imagery improved motor recovery 
      when associated with physical therapy, with motor performance remaining stable
      over the 1-month period. We concluded that motor imagery should be successfully
      associated with classic rehabilitation procedure after tendon transfer. Physical 
      sessions may thus be shortened if too stressful or painful.
CI  - Copyright 2010 American Congress of Rehabilitation Medicine. Published by
      Elsevier Inc. All rights reserved.
FAU - Grangeon, Murielle
AU  - Grangeon M
AD  - Universite de Lyon, Universite Claude Bernard Lyon1, Centre de Recherche et
      d'Innovation sur le Sport, Equipe d'Accueil 647, Laboratoire de la Performance
      Motrice, Mentale et du Materiel, Villeurbanne Cedex, France.
FAU - Guillot, Aymeric
AU  - Guillot A
FAU - Sancho, Pierre-Olivier
AU  - Sancho PO
FAU - Picot, Marion
AU  - Picot M
FAU - Revol, Patrice
AU  - Revol P
FAU - Rode, Gilles
AU  - Rode G
FAU - Collet, Christian
AU  - Collet C
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Arch Phys Med Rehabil
JT  - Archives of physical medicine and rehabilitation
JID - 2985158R
SB  - IM
MH  - Adult
MH  - Biomechanical Phenomena
MH  - Cross-Over Studies
MH  - *Elbow Joint
MH  - Humans
MH  - *Imagery, Psychotherapy
MH  - Male
MH  - *Physical Therapy Modalities
MH  - Quadriplegia/etiology/*surgery
MH  - Spinal Cord Injuries/complications
MH  - Tendon Transfer/*rehabilitation
EDAT- 2010/07/06 06:00
MHDA- 2010/07/24 06:00
CRDT- 2010/07/06 06:00
PHST- 2010/03/30 00:00 [received]
PHST- 2010/04/16 00:00 [accepted]
PHST- 2010/07/06 06:00 [entrez]
PHST- 2010/07/06 06:00 [pubmed]
PHST- 2010/07/24 06:00 [medline]
AID - S0003-9993(10)00239-X [pii]
AID - 10.1016/j.apmr.2010.04.011 [doi]
PST - ppublish
SO  - Arch Phys Med Rehabil. 2010 Jul;91(7):1143-6. doi: 10.1016/j.apmr.2010.04.011.


PMID- 20598577
OWN - NLM
STAT- MEDLINE
DCOM- 20110414
LR  - 20220316
IS  - 1532-8511 (Electronic)
IS  - 1052-3057 (Linking)
VI  - 20
IP  - 1
DP  - 2011 Jan-Feb
TI  - RETRACTED: An open-label trial comparing alendronate and alphacalcidol in
      reducing falls and hip fractures in disabled stroke patients.
PG  - 41-46
LID - S1052-3057(09)00224-9 [pii]
LID - 10.1016/j.jstrokecerebrovasdis.2009.10.007 [doi]
AB  - This article has been retracted: please see Elsevier Policy on Article Withdrawal
      (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This
      article has been retracted at the request of the Editor-in-Chief due to include
      issues around study governance (ethical oversight and funding), implausible
      participant recruitment, implausible study conduct and publication timelines,
      authorship misconduct, conflicting statements about randomization methodology,
      implausibly similar randomized groups, implausible results, impossible results,
      duplicate reporting and data errors. In addition, several other publications
      reporting non-randomized research by members of this group of investigators have 
      been retracted.
CI  - Copyright A(c) 2011 National Stroke Association. Published by Elsevier Inc. All
      rights reserved.
FAU - Sato, Yoshihiro
AU  - Sato Y
AD  - Department of Neurology, Mitate Hospital, Tagawa, Japan. Electronic address:
      y-sato@ktarn.or.jp.
FAU - Iwamoto, Jun
AU  - Iwamoto J
AD  - Institute for Sports Medicine, Keio University School of Medicine, Tokyo, Japan.
FAU - Honda, Yoshiaki
AU  - Honda Y
AD  - Department of Neurology, Mitate Hospital, Tagawa, Japan.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Retracted Publication
DEP - 20100703
PL  - United States
TA  - J Stroke Cerebrovasc Dis
JT  - Journal of stroke and cerebrovascular diseases : the official journal of National
      Stroke Association
JID - 9111633
RN  - 0 (Bone Density Conservation Agents)
RN  - 0 (Hydroxycholecalciferols)
RN  - FXC9231JVH (Calcitriol)
RN  - URQ2517572 (alfacalcidol)
RN  - X1J18R4W8P (Alendronate)
SB  - IM
RIN - J Stroke Cerebrovasc Dis. 2019 Nov;28(11):104426. PMID: 31668218
MH  - Accidental Falls/*prevention & control
MH  - Aged
MH  - Alendronate/*therapeutic use
MH  - Bone Density
MH  - Bone Density Conservation Agents/*therapeutic use
MH  - Bone and Bones/metabolism/pathology
MH  - Calcitriol/blood
MH  - Disabled Persons/*statistics & numerical data
MH  - Female
MH  - Hip Fractures/*prevention & control
MH  - Humans
MH  - Hydroxycholecalciferols/*therapeutic use
MH  - Male
MH  - Stroke/*complications
EDAT- 2010/07/06 06:00
MHDA- 2011/04/16 06:00
CRDT- 2010/07/06 06:00
PHST- 2009/04/28 00:00 [received]
PHST- 2009/08/22 00:00 [revised]
PHST- 2009/10/26 00:00 [accepted]
PHST- 2010/07/06 06:00 [entrez]
PHST- 2010/07/06 06:00 [pubmed]
PHST- 2011/04/16 06:00 [medline]
AID - S1052-3057(09)00224-9 [pii]
AID - 10.1016/j.jstrokecerebrovasdis.2009.10.007 [doi]
PST - ppublish
SO  - J Stroke Cerebrovasc Dis. 2011 Jan-Feb;20(1):41-46. doi:
      10.1016/j.jstrokecerebrovasdis.2009.10.007. Epub 2010 Jul 3.


PMID- 20598435
OWN - NLM
STAT- MEDLINE
DCOM- 20110112
LR  - 20100809
IS  - 1879-291X (Electronic)
IS  - 0301-5629 (Linking)
VI  - 36
IP  - 8
DP  - 2010 Aug
TI  - Nonmedical use of ultrasound in pregnancy: ethical issues, patients' rights and
      potential misuse.
PG  - 1233-6
LID - 10.1016/j.ultrasmedbio.2010.04.004 [doi]
FAU - Brezinka, Christoph
AU  - Brezinka C
LA  - eng
PT  - Letter
DEP - 20100703
PL  - England
TA  - Ultrasound Med Biol
JT  - Ultrasound in medicine & biology
JID - 0410553
SB  - IM
MH  - *Consumer Product Safety
MH  - Europe
MH  - Female
MH  - *Health Services Misuse
MH  - Humans
MH  - Patient Rights/*ethics
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*prevention & control
MH  - Ultrasonography, Prenatal/ethics
EDAT- 2010/07/06 06:00
MHDA- 2011/01/13 06:00
CRDT- 2010/07/06 06:00
PHST- 2009/06/02 00:00 [received]
PHST- 2010/04/04 00:00 [revised]
PHST- 2010/04/10 00:00 [accepted]
PHST- 2010/07/06 06:00 [entrez]
PHST- 2010/07/06 06:00 [pubmed]
PHST- 2011/01/13 06:00 [medline]
AID - S0301-5629(10)00182-1 [pii]
AID - 10.1016/j.ultrasmedbio.2010.04.004 [doi]
PST - ppublish
SO  - Ultrasound Med Biol. 2010 Aug;36(8):1233-6. doi:
      10.1016/j.ultrasmedbio.2010.04.004. Epub 2010 Jul 3.


PMID- 20598404
OWN - NLM
STAT- MEDLINE
DCOM- 20110606
LR  - 20120910
IS  - 1532-2793 (Electronic)
IS  - 0260-6917 (Linking)
VI  - 31
IP  - 2
DP  - 2011 Feb
TI  - Health science students' conceptions of group supervision.
PG  - 179-83
LID - 10.1016/j.nedt.2010.05.015 [doi]
AB  - AIM: The aim of this study was to describe health science university students'
      conceptions of group supervision during work on bachelor's thesis. METHOD: This
      study is a qualitative research. Data were collected with an open data collection
      form from health science students (N=77). It was analysed by using inductive
      content analysis, conducted by a multidisciplinary research team. ETHICAL ISSUES:
      Appropriate ethical principles and scientific practice were followed. All the
      participants provided informed consent. RESULTS: Students' conceptions of group
      supervisions consisted of organization of group supervision, the nature of
      supervision, the interaction between students, the role of the supervisor and
      learning results. CONCLUSION: Group supervision is a student-centred and
      problem-based method of supervision achieving a common target. It consists of
      interaction between students and supervisor. The supervisor's role is profiled as
      scientific and substantial expertise. Group supervision is a suitable supervision
      method for achieving theoretical and practical scientific skills.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Kangasniemi, Mari
AU  - Kangasniemi M
AD  - University of Eastern Finland, Faculty of Health Sciences, Department of Nursing 
      Science, P.O. Box 1627, 70211 Kuopio, Finland. mari.kangasniemi@uef.fi
FAU - Ahonen, Sanna-Mari
AU  - Ahonen SM
FAU - Liikanen, Eeva
AU  - Liikanen E
FAU - Utriainen, Kati
AU  - Utriainen K
LA  - eng
PT  - Journal Article
DEP - 20100702
PL  - Scotland
TA  - Nurse Educ Today
JT  - Nurse education today
JID - 8511379
MH  - *Attitude of Health Personnel
MH  - Data Collection
MH  - Education, Nursing, Baccalaureate/*organization & administration
MH  - Finland
MH  - Group Processes
MH  - Health Personnel/*education/psychology
MH  - Humans
MH  - Learning
MH  - *Peer Group
MH  - Qualitative Research
MH  - *Social Perception
MH  - Students, Nursing/*psychology
EDAT- 2010/07/06 06:00
MHDA- 2011/06/07 06:00
CRDT- 2010/07/06 06:00
PHST- 2009/10/06 00:00 [received]
PHST- 2010/04/09 00:00 [revised]
PHST- 2010/05/28 00:00 [accepted]
PHST- 2010/07/06 06:00 [entrez]
PHST- 2010/07/06 06:00 [pubmed]
PHST- 2011/06/07 06:00 [medline]
AID - S0260-6917(10)00103-6 [pii]
AID - 10.1016/j.nedt.2010.05.015 [doi]
PST - ppublish
SO  - Nurse Educ Today. 2011 Feb;31(2):179-83. doi: 10.1016/j.nedt.2010.05.015. Epub
      2010 Jul 2.


PMID- 20597745
OWN - NLM
STAT- MEDLINE
DCOM- 20100804
LR  - 20201209
IS  - 1934-9491 (Print)
IS  - 1934-9491 (Linking)
VI  - 48
IP  - 2
DP  - 2010 Apr
TI  - Adults with intellectual and developmental disabilities and participation in
      decision making: ethical considerations for professional-client practice.
PG  - 112-25
LID - 10.1352/1934-9556-48.2.112 [doi]
AB  - In this article, the authors challenge professionals to re-examine assumptions
      about basic concepts and their implications in supporting adults with
      intellectual and developmental disabilities. The authors focus on decisions with 
      significant implications, such as planning transition from school to adult life, 
      changing living environments, and managing health issues. The analysis highlights
      important concepts that are less often addressed: autonomy, empowerment,
      participation in decision making, asymmetrical power, outer-directedness, and
      respect for persons. The authors suggest that professionals adopt a moral
      principle of respect for persons as an overarching guiding principle in their
      work with adults with intellectual and developmental disabilities. The value of
      self-determination and person-centered planning processes are placed in the
      larger scope of ethical practice. The authors offer a set of practical
      considerations that encourage respect for these individuals by involving them in 
      the decision-making process in situations that have a large impact on them.
FAU - Lotan, Gurit
AU  - Lotan G
AD  - Department of Psychology, Job Training and Job Integration Program, Summit
      School, Ville St. Laurent, Quebec, Canada. gurit@summit-school.com
FAU - Ells, Carolyn
AU  - Ells C
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Intellect Dev Disabil
JT  - Intellectual and developmental disabilities
JID - 101299965
SB  - IM
MH  - Adult
MH  - Decision Making/*ethics
MH  - Disabled Persons/psychology/*rehabilitation
MH  - Humans
MH  - Patient Care Team/ethics
MH  - Patient Education as Topic/ethics
MH  - *Patient Participation
MH  - Personal Autonomy
MH  - Persons with Mental Disabilities/psychology/*rehabilitation
MH  - Power, Psychological
MH  - Professional-Patient Relations/*ethics
RF  - 49
EDAT- 2010/07/06 06:00
MHDA- 2010/08/05 06:00
CRDT- 2010/07/06 06:00
PHST- 2010/07/06 06:00 [entrez]
PHST- 2010/07/06 06:00 [pubmed]
PHST- 2010/08/05 06:00 [medline]
AID - 10.1352/1934-9556-48.2.112 [pii]
AID - 10.1352/1934-9556-48.2.112 [doi]
PST - ppublish
SO  - Intellect Dev Disabil. 2010 Apr;48(2):112-25. doi: 10.1352/1934-9556-48.2.112.


PMID- 20597593
OWN - NLM
STAT- MEDLINE
DCOM- 20101014
LR  - 20211020
IS  - 1465-7309 (Electronic)
IS  - 1067-3229 (Linking)
VI  - 18
IP  - 4
DP  - 2010 Jul-Aug
TI  - Defining neuromarketing: practices and professional challenges.
PG  - 230-7
LID - 10.3109/10673229.2010.496623 [doi]
AB  - Neuromarketing has recently generated controversies concerning the involvement of
      medical professionals, and many key questions remain-ones that have potentially
      important implications for the field of psychiatry. Conflicting definitions of
      neuromarketing have been proposed, and little is known about the actual practices
      of companies, physicians, and scientists involved in its practice. This article
      reviews the history of neuromarketing and uses an exploratory survey of
      neuromarketing Web sites to illustrate ethical issues raised by this new field.
      Neuromarketing, as currently practiced, is heterogeneous, as companies are
      offering a variety of technologies. Many companies employ academicians and
      professionals, but few list their clients or fees. Media coverage of
      neuromarketing appears disproportionately high compared to the paucity of
      peer-reviewed reports in the field. Companies may be making premature claims
      about the power of neuroscience to predict consumer behavior. Overall,
      neuromarketing has important implications for academic-industrial partnerships,
      the responsible conduct of research, and the public understanding of the brain.
      We explore these themes to uncover issues relevant to professional ethics,
      research, and policy. Of particular relevance to psychiatry, neuromarketing may
      be seen as an extension of the search for quantification and certainty in
      previously indefinite aspects of human behavior.
FAU - Fisher, Carl Erik
AU  - Fisher CE
AD  - Department of Psychiatry, Columbia University, New York, NY, USA.
      cf2141@columbia.edu <cf2141@columbia.edu>
FAU - Chin, Lisa
AU  - Chin L
FAU - Klitzman, Robert
AU  - Klitzman R
LA  - eng
GR  - T32 MH19139/MH/NIMH NIH HHS/United States
GR  - P30 MH043520/MH/NIMH NIH HHS/United States
GR  - R01 HG004214/HG/NHGRI NIH HHS/United States
GR  - R01 HG004214-01/HG/NHGRI NIH HHS/United States
GR  - T32 MH019139/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
PL  - United States
TA  - Harv Rev Psychiatry
JT  - Harvard review of psychiatry
JID - 9312789
SB  - IM
MH  - Brain/physiopathology
MH  - Computer Graphics/ethics
MH  - *Conflict of Interest
MH  - Diffusion of Innovation
MH  - *Ethics, Professional
MH  - *Ethics, Research
MH  - Health Education/ethics
MH  - Humans
MH  - Industry/*ethics
MH  - Internet/ethics
MH  - Interprofessional Relations/*ethics
MH  - Magnetic Resonance Imaging
MH  - Neurosciences/*ethics
MH  - Psychiatry/*ethics
MH  - Social Marketing/*ethics
MH  - Social Responsibility
MH  - United States
PMC - PMC3152487
MID - NIHMS314513
EDAT- 2010/07/06 06:00
MHDA- 2010/10/15 06:00
CRDT- 2010/07/06 06:00
PHST- 2010/07/06 06:00 [entrez]
PHST- 2010/07/06 06:00 [pubmed]
PHST- 2010/10/15 06:00 [medline]
AID - 10.3109/10673229.2010.496623 [doi]
PST - ppublish
SO  - Harv Rev Psychiatry. 2010 Jul-Aug;18(4):230-7. doi: 10.3109/10673229.2010.496623.


PMID- 20596783
OWN - NLM
STAT- MEDLINE
DCOM- 20100819
LR  - 20100719
IS  - 1573-0980 (Electronic)
IS  - 1386-7415 (Linking)
VI  - 31
IP  - 4
DP  - 2010 Aug
TI  - Ethics and the generous ontology.
PG  - 259-70
LID - 10.1007/s11017-010-9148-7 [doi]
AB  - According to a view attractive to both metaphysicians and ethicists, every period
      in a person's life is the life of a being just like that person except that it
      exists only during that period. These "subpeople" appear to have moral status,
      and their interests seem to clash with ours: though it may be in some person's
      interests to sacrifice for tomorrow, it is not in the interests of a subperson
      coinciding with him only today, who will never benefit from it. Or perhaps there 
      is no clash, and a subperson's interests derive from those of the person it
      coincides with. But this makes it likely that our own interests derive from those
      of other beings coinciding with us.
FAU - Olson, Eric T
AU  - Olson ET
AD  - Department of Philosophy, University of Sheffield, Sheffield, S3 7QB, UK.
      e.olson@shef.ac.uk
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Theor Med Bioeth
JT  - Theoretical medicine and bioethics
JID - 9805378
SB  - IM
MH  - Bioethical Issues
MH  - *Conflict of Interest
MH  - Ethical Analysis
MH  - Humans
MH  - Linguistics
MH  - *Moral Obligations
MH  - *Personhood
MH  - *Self Concept
EDAT- 2010/07/03 06:00
MHDA- 2010/08/20 06:00
CRDT- 2010/07/03 06:00
PHST- 2010/07/03 06:00 [entrez]
PHST- 2010/07/03 06:00 [pubmed]
PHST- 2010/08/20 06:00 [medline]
AID - 10.1007/s11017-010-9148-7 [doi]
PST - ppublish
SO  - Theor Med Bioeth. 2010 Aug;31(4):259-70. doi: 10.1007/s11017-010-9148-7.


PMID- 20596687
OWN - NLM
STAT- MEDLINE
DCOM- 20110228
LR  - 20211020
IS  - 1432-1289 (Electronic)
IS  - 0020-9554 (Linking)
VI  - 51
IP  - 10
DP  - 2010 Oct
TI  - [38 year-old patient with suspected congenital hormonal dysfunction].
PG  - 1318-20, 1322-3
LID - 10.1007/s00108-010-2615-4 [doi]
AB  - We present the case of a patient with suspected congenital hypopituitarism first 
      diagnosed at the age of 38 years. Despite partial insufficiency of all
      pituitary-regulated hormonal axes, the patient never suffered from severe health 
      problems. However, the patient was disfigured, and his intellectual and physical 
      capacities were clearly impaired. The initiation of a hormone replacement therapy
      with hydrocortisone and thyroid hormones is essential in such a patient, but the 
      substitution of sex hormones can create ethical problems.
FAU - Bergmann, T
AU  - Bergmann T
AD  - Schwerpunkt Endokrinologie und Stoffwechsel, Medizinische Klinik 1,
      Friedrich-Alexander-Universitat Erlangen-Nurnberg, Erlangen, Deutschland.
      tanja.bergmann@uk-erlangen.de
FAU - Hahn, E G
AU  - Hahn EG
FAU - Lohse, P
AU  - Lohse P
FAU - Harsch, I A
AU  - Harsch IA
LA  - ger
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - 38-jahriger Patient mit Verdacht auf eine angeborene hormonelle Storung.
PL  - Germany
TA  - Internist (Berl)
JT  - Der Internist
JID - 0264620
RN  - 0 (Thyroid Hormones)
RN  - 12629-01-5 (Human Growth Hormone)
RN  - 3XMK78S47O (Testosterone)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adult
MH  - Diagnosis, Differential
MH  - Ethics, Medical
MH  - Hormone Replacement Therapy/ethics
MH  - Human Growth Hormone/therapeutic use
MH  - Humans
MH  - Hydrocortisone/therapeutic use
MH  - Hypogonadism/congenital/diagnosis/drug therapy
MH  - Hypopituitarism/*congenital/diagnosis/drug therapy
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Osteoporosis/congenital/diagnosis/drug therapy
MH  - Pituitary Function Tests
MH  - Testosterone/therapeutic use
MH  - Thyroid Hormones/therapeutic use
EDAT- 2010/07/03 06:00
MHDA- 2011/03/01 06:00
CRDT- 2010/07/03 06:00
PHST- 2010/07/03 06:00 [entrez]
PHST- 2010/07/03 06:00 [pubmed]
PHST- 2011/03/01 06:00 [medline]
AID - 10.1007/s00108-010-2615-4 [doi]
PST - ppublish
SO  - Internist (Berl). 2010 Oct;51(10):1318-20, 1322-3. doi:
      10.1007/s00108-010-2615-4.


PMID- 20596361
OWN - NLM
STAT- MEDLINE
DCOM- 20100915
LR  - 20211020
IS  - 1449-1907 (Electronic)
IS  - 1449-1907 (Linking)
VI  - 7
IP  - 4
DP  - 2010 Jun 10
TI  - Efficacy of sirolimus-eluting stents compared with paclitaxel-eluting stents in
      an unselected population with coronary artery disease: 24-month outcomes of
      patients in a prospective non-randomized registry in Southern Turkey.
PG  - 191-6
AB  - BACKGROUND: The efficacy of drug-eluting stents has been shown in randomized
      trials, but some controversy exists regarding which stent sirolimus-eluting or
      paclitaxel-eluting is more effective in unselected Turkish patients. Therefore,
      we investigated the clinical outcomes of patients who were treated with one type 
      of these drug-eluting stents in the real world. METHODS: We created a registry
      and prospectively analyzed data on a consecutive series of all patients who
      presented to our institution with symptomatic coronary artery disease between
      February 2005 and March 2007 and who were treated with the sirolimus- or the
      paclitaxel-eluting stent. The follow-up period after stent implantation was
      approximately 24 months. The primary end point was a major cardiac event, and the
      secondary end point was stent thrombosis. Informed consent was obtained from all 
      subjects, and the study protocol was approved by the local ethical committee.
      RESULTS: In total, 204 patients were treated with either the sirolimus-eluting
      stent (n = 103) or the paclitaxel-eluting stent (n = 101). The lesions in the 2
      arms of the study were treated similarly by conventional technique. At 24-month
      follow-up, patients who received the paclitaxel-eluting stent showed
      significantly higher rates of non-Q-wave myocardial infarction (1.9% vs 5.9%; P: 
      .002), target vessel revascularization (1.9% vs 4.9%; P: .002), coronary artery
      bypass graft surgery (1.9% vs 6.9%; P: .001), and late stent thrombosis (1.9% vs 
      3.9%, P: .002). CONCLUSIONS: Patients who received the sirolimus-eluting stent
      showed better clinical outcomes compared with those who had the
      paclitaxel-eluting-stent.
FAU - Cicek, Davran
AU  - Cicek D
AD  - Baskent University School of Medicine, Department of Cardiology, Antalya, Turkey.
      davrancicek@mynet.com
FAU - Pekdemir, Hasan
AU  - Pekdemir H
FAU - Kalay, Nihat
AU  - Kalay N
FAU - Binici, Suleyman
AU  - Binici S
FAU - Altay, Hakan
AU  - Altay H
FAU - Muderrisoglu, Haldun
AU  - Muderrisoglu H
LA  - eng
PT  - Journal Article
DEP - 20100610
PL  - Australia
TA  - Int J Med Sci
JT  - International journal of medical sciences
JID - 101213954
RN  - P88XT4IS4D (Paclitaxel)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
MH  - Aged
MH  - Angioplasty, Balloon, Coronary/*methods
MH  - Coronary Artery Disease/drug therapy/*therapy
MH  - *Drug-Eluting Stents
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Paclitaxel/*therapeutic use
MH  - Prospective Studies
MH  - Sirolimus/*therapeutic use
MH  - Treatment Outcome
MH  - Turkey
PMC - PMC2894220
OTO - NOTNLM
OT  - coronary artery disease
OT  - drug-eluting stent
OT  - major adverse cardiac event
OT  - stent thrombosis.
EDAT- 2010/07/03 06:00
MHDA- 2010/09/17 06:00
CRDT- 2010/07/03 06:00
PHST- 2010/04/27 00:00 [received]
PHST- 2010/06/04 00:00 [accepted]
PHST- 2010/07/03 06:00 [entrez]
PHST- 2010/07/03 06:00 [pubmed]
PHST- 2010/09/17 06:00 [medline]
AID - 10.7150/ijms.7.191 [doi]
PST - epublish
SO  - Int J Med Sci. 2010 Jun 10;7(4):191-6. doi: 10.7150/ijms.7.191.


PMID- 20596120
OWN - NLM
STAT- MEDLINE
DCOM- 20100708
LR  - 20100702
IS  - 0807-7096 (Electronic)
IS  - 0029-2001 (Linking)
VI  - 130
IP  - 13
DP  - 2010 Jul 1
TI  - [Publishing ethics--about intermediating science understandably and reliably].
PG  - 1359-61
LID - 10.4045/tidsskr.10.0552 [doi]
FAU - Riis, Povl
AU  - Riis P
AD  - aha@aeldreforum.dk
LA  - nor
PT  - Journal Article
TT  - Publikationsetik--om at formidle videnskab forstaeligt og trovaerdigt.
PL  - Norway
TA  - Tidsskr Nor Laegeforen
JT  - Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny
      raekke
JID - 0413423
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Ethics, Research
MH  - Evidence-Based Medicine/ethics
MH  - Humans
MH  - Peer Review, Research/ethics
MH  - Publishing/*ethics
MH  - Scientific Misconduct/ethics
EDAT- 2010/07/03 06:00
MHDA- 2010/07/09 06:00
CRDT- 2010/07/03 06:00
PHST- 2010/07/03 06:00 [entrez]
PHST- 2010/07/03 06:00 [pubmed]
PHST- 2010/07/09 06:00 [medline]
AID - 1993603 [pii]
AID - 10.4045/tidsskr.10.0552 [doi]
PST - ppublish
SO  - Tidsskr Nor Laegeforen. 2010 Jul 1;130(13):1359-61. doi: 10.4045/tidsskr.10.0552.


PMID- 20596067
OWN - NLM
STAT- MEDLINE
DCOM- 20101019
LR  - 20101129
IS  - 1476-5373 (Electronic)
IS  - 0007-0610 (Linking)
VI  - 209
IP  - 1
DP  - 2010 Jul 10
TI  - Experience in third molar surgery: an update.
PG  - E1
LID - 10.1038/sj.bdj.2010.581 [doi]
AB  - BACKGROUND: The relationship between a surgeon's experience and the incidence of 
      postoperative complications after third molar surgery is assessed in this
      prospective clinical study. Previous reports have shown this to be one the most
      influential factors on surgical outcome. METHOD: In this study, 3,236 patients
      underwent surgical removal of impacted third molars. All patients included in the
      study were reviewed and the various postoperative complications were recorded and
      statistically compared to the surgeon's grade. Patients' demographics and
      pre-operative radiographic findings were also noted. RESULTS: The surgical
      procedures were performed by seven specialists and 12 residents. In the group of 
      patients treated by the residents, the incidence of postoperative complications
      was found to be significant with regards to trismus, infection, alveolar osteitis
      and paraesthesia of the lingual and inferior alveolar nerves. In the group of
      patients treated by specialists, the incidence of postoperative bleeding was
      found to be statistically significant. CONCLUSION: There is without doubt a
      relationship between the surgeon's experience and the postoperative complication 
      in third molar surgery. The impact of the findings from this study upon the
      profession, education and research is as yet unrealised. The ethical and moral
      implications of our findings are discussed.
FAU - Jerjes, W
AU  - Jerjes W
AD  - UCLH Head and Neck Centre, 250 Euston Road, London, NW1 2PG.
      waseem_wk1@yahoo.co.uk
FAU - Upile, T
AU  - Upile T
FAU - Nhembe, F
AU  - Nhembe F
FAU - Gudka, D
AU  - Gudka D
FAU - Shah, P
AU  - Shah P
FAU - Abbas, S
AU  - Abbas S
FAU - McCarthy, E
AU  - McCarthy E
FAU - Patel, S
AU  - Patel S
FAU - Mahil, J
AU  - Mahil J
FAU - Hopper, C
AU  - Hopper C
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
DEP - 20100702
PL  - England
TA  - Br Dent J
JT  - British dental journal
JID - 7513219
SB  - IM
CIN - Br Dent J. 2010 Jul 10;209(1):36-7. PMID: 20616839
CIN - Br Dent J. 2010 Nov;209(9):423-4. PMID: 21072071
MH  - Adolescent
MH  - Adult
MH  - Chi-Square Distribution
MH  - *Clinical Competence
MH  - Female
MH  - Humans
MH  - Internship and Residency
MH  - Likelihood Functions
MH  - London
MH  - Male
MH  - Molar, Third/*surgery
MH  - *Postoperative Complications
MH  - Prospective Studies
MH  - Surgery, Oral
MH  - *Tooth Extraction
MH  - Tooth, Impacted/*surgery
MH  - Young Adult
EDAT- 2010/07/03 06:00
MHDA- 2010/10/20 06:00
CRDT- 2010/07/03 06:00
PHST- 2010/03/26 00:00 [accepted]
PHST- 2010/07/03 06:00 [entrez]
PHST- 2010/07/03 06:00 [pubmed]
PHST- 2010/10/20 06:00 [medline]
AID - sj.bdj.2010.581 [pii]
AID - 10.1038/sj.bdj.2010.581 [doi]
PST - ppublish
SO  - Br Dent J. 2010 Jul 10;209(1):E1. doi: 10.1038/sj.bdj.2010.581. Epub 2010 Jul 2.


PMID- 20595992
OWN - NLM
STAT- MEDLINE
DCOM- 20100806
LR  - 20100702
IS  - 1476-4687 (Electronic)
IS  - 0028-0836 (Linking)
VI  - 466
IP  - 7302
DP  - 2010 Jul 1
TI  - Sino-European research ethics on the right path.
PG  - 28
LID - 10.1038/466028c [doi]
FAU - Rehmann-Sutter, Christoph
AU  - Rehmann-Sutter C
LA  - eng
PT  - Letter
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
SB  - IM
MH  - Biomedical Research/*ethics/trends
MH  - China
MH  - Ethics Committees, Research/organization & administration
MH  - *Ethics, Research
MH  - Europe
MH  - *Guidelines as Topic
MH  - Humans
MH  - International Cooperation
EDAT- 2010/07/03 06:00
MHDA- 2010/08/07 06:00
CRDT- 2010/07/03 06:00
PHST- 2010/07/03 06:00 [entrez]
PHST- 2010/07/03 06:00 [pubmed]
PHST- 2010/08/07 06:00 [medline]
AID - 466028c [pii]
AID - 10.1038/466028c [doi]
PST - ppublish
SO  - Nature. 2010 Jul 1;466(7302):28. doi: 10.1038/466028c.


PMID- 20595946
OWN - NLM
STAT- MEDLINE
DCOM- 20101223
LR  - 20100702
IS  - 0026-4784 (Print)
IS  - 0026-4784 (Linking)
VI  - 62
IP  - 3
DP  - 2010 Jun
TI  - Preimplantation genetic diagnosis.
PG  - 213-23
AB  - Preimplantation genetic diagnosis (PGD) is the screening of embryos at the
      cleavage stage in order to select and transfer only the desired embryo. The main 
      indications of PGD are monogenic disorders and aneuploidy. This article reviews
      the recent advances in PGD methodology and presents their advantages,
      disadvantages and challenges. Ethical considerations arising with more widespread
      use of PGD for physical traits is also discussed. PGD for monogenic disorders
      remains the most successful indication, but is technically more challenging. PGS 
      for aneuploidy has passed through a period of reconsideration and is now
      re-emerging with complete genome screening.
FAU - Lalioti, M D
AU  - Lalioti MD
AD  - Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University
      School of Medicine, New Haven, CT, USA. maria.lalioti@yale.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - Minerva Ginecol
JT  - Minerva ginecologica
JID - 0400731
SB  - IM
MH  - Biopsy
MH  - Blastocyst/pathology
MH  - Female
MH  - Humans
MH  - Polymerase Chain Reaction
MH  - Pregnancy
MH  - *Preimplantation Diagnosis/ethics/methods
EDAT- 2010/07/03 06:00
MHDA- 2010/12/25 06:00
CRDT- 2010/07/03 06:00
PHST- 2010/07/03 06:00 [entrez]
PHST- 2010/07/03 06:00 [pubmed]
PHST- 2010/12/25 06:00 [medline]
AID - R09103138 [pii]
PST - ppublish
SO  - Minerva Ginecol. 2010 Jun;62(3):213-23.


PMID- 20595713
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20100728
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 8
DP  - 2010 Aug
TI  - Seclusion and its context in acute inpatient psychiatric care.
PG  - 459-62
LID - 10.1136/jme.2010.035402 [doi]
AB  - In acute inpatient mental health services, patients commonly demonstrate extreme 
      behaviours. A number of coercive practices, such as locked doors, enforced
      medication and seclusion, are used in these settings to control such behaviours. 
      The aim of this report is to explore briefly some of the contemporary debates
      pertaining to seclusion. A perusal of the literature reveals a clarion call to
      end the practice of seclusion, without consideration of feasible alternatives. It
      is hoped that this brief report will encourage further evidence-based discussion 
      and research initiatives on this important ethical topic.
FAU - Cleary, Michelle
AU  - Cleary M
AD  - Family & Community Health Research Group, School of Nursing & Midwifery,
      University of Western Sydney, Sydney, NSW, Australia. m.cleary@uws.edu.au
FAU - Hunt, Glenn E
AU  - Hunt GE
FAU - Walter, Garry
AU  - Walter G
LA  - eng
PT  - Journal Article
DEP - 20100701
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Attitude of Health Personnel
MH  - Australia
MH  - Hospitalization
MH  - Hospitals, Psychiatric/ethics/*standards
MH  - Humans
MH  - Inpatients/*psychology
MH  - Mental Disorders/nursing/*psychology
MH  - Mentally Ill Persons/*psychology
MH  - Patient Isolation/*psychology
MH  - Psychiatric Nursing/*methods
MH  - Restraint, Physical/psychology
MH  - Social Isolation
EDAT- 2010/07/03 06:00
MHDA- 2011/11/09 06:00
CRDT- 2010/07/03 06:00
PHST- 2010/07/03 06:00 [entrez]
PHST- 2010/07/03 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - jme.2010.035402 [pii]
AID - 10.1136/jme.2010.035402 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Aug;36(8):459-62. doi: 10.1136/jme.2010.035402. Epub 2010 Jul 
      1.


PMID- 20595601
OWN - NLM
STAT- MEDLINE
DCOM- 20100713
LR  - 20110630
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Linking)
VI  - 329
IP  - 5987
DP  - 2010 Jul 2
TI  - Genetic technologies. Synthetic "life," ethics, national security, and public
      discourse.
PG  - 38-9
LID - 10.1126/science.1193749 [doi]
FAU - Cho, Mildred K
AU  - Cho MK
AD  - Stanford University, Stanford, CA 94305, USA. micho@stanford.edu
FAU - Relman, David A
AU  - Relman DA
LA  - eng
GR  - DP1-OD000964/OD/NIH HHS/United States
GR  - P50 HG003389/HG/NHGRI NIH HHS/United States
GR  - U54 RR024374-01A1/RR/NCRR NIH HHS/United States
PT  - Comment
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
SB  - IM
CON - Science. 2010 Jul 2;329(5987):52-6. PMID: 20488990
MH  - *Bioengineering/ethics/methods
MH  - *Bioethical Issues
MH  - *Genetic Engineering/ethics/methods
MH  - Genetic Techniques/ethics
MH  - *Genome, Bacterial
MH  - *Genomics/ethics/methods
MH  - Public Opinion
MH  - *Public Policy
MH  - Risk Assessment
MH  - *Security Measures
MH  - United States
EDAT- 2010/07/03 06:00
MHDA- 2010/07/14 06:00
CRDT- 2010/07/03 06:00
PHST- 2010/07/03 06:00 [entrez]
PHST- 2010/07/03 06:00 [pubmed]
PHST- 2010/07/14 06:00 [medline]
AID - 329/5987/38 [pii]
AID - 10.1126/science.1193749 [doi]
PST - ppublish
SO  - Science. 2010 Jul 2;329(5987):38-9. doi: 10.1126/science.1193749.


PMID- 20595438
OWN - NLM
STAT- MEDLINE
DCOM- 20101004
LR  - 20181201
IS  - 1526-3347 (Electronic)
IS  - 0191-9601 (Linking)
VI  - 31
IP  - 7
DP  - 2010 Jul
TI  - The ethics of complementary and alternative medicine.
PG  - e49-51
LID - 10.1542/pir.31-7-e49 [doi]
FAU - Mears, Brenda J
AU  - Mears BJ
AD  - Department of Pediatrics, University of Texas at Southwestern Medical School,
      Dallas, TX, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pediatr Rev
JT  - Pediatrics in review
JID - 8103046
SB  - IM
MH  - Complementary Therapies/*ethics/legislation & jurisprudence/statistics &
      numerical data
MH  - Humans
MH  - Patient Preference
MH  - Patient Rights
MH  - United States
EDAT- 2010/07/03 06:00
MHDA- 2010/10/05 06:00
CRDT- 2010/07/03 06:00
PHST- 2010/07/03 06:00 [entrez]
PHST- 2010/07/03 06:00 [pubmed]
PHST- 2010/10/05 06:00 [medline]
AID - 31/7/e49 [pii]
AID - 10.1542/pir.31-7-e49 [doi]
PST - ppublish
SO  - Pediatr Rev. 2010 Jul;31(7):e49-51. doi: 10.1542/pir.31-7-e49.


PMID- 20594801
OWN - NLM
STAT- MEDLINE
DCOM- 20110225
LR  - 20151119
IS  - 1873-6513 (Electronic)
IS  - 0885-3924 (Linking)
VI  - 40
IP  - 5
DP  - 2010 Nov
TI  - Long-term safety and tolerability of fentanyl buccal tablet for the treatment of 
      breakthrough pain in opioid-tolerant patients with chronic pain: an 18-month
      study.
PG  - 747-60
LID - 10.1016/j.jpainsymman.2010.02.009 [doi]
AB  - CONTEXT: Breakthrough pain (BTP) is highly prevalent in patients with chronic
      cancer and noncancer pain, commonly requiring treatment with short-acting or
      rapid-onset opioids. This is the first report of an analysis of long-term safety 
      from combined clinical trials of a rapid-onset transmucosal formulation of
      fentanyl, the fentanyl buccal tablet (FBT). OBJECTIVES: This long-term
      (18-month), open-label study assessed the safety and tolerability of FBT for the 
      treatment of BTP in a large cohort (n=646) of opioid-tolerant patients receiving 
      around-the-clock (ATC) opioids for persistant noncancer pain. METHODS: This was a
      long-term, multicenter, open-label safety study that accepted patients naive to
      FBT (new patients) as well as rollover patients from one of two previous
      short-term, randomized, placebo-controlled studies involving opioid-tolerant
      adults with chronic noncancer pain. All patients gave written informed consent,
      and the study was conducted according to Good Clinical Practice and with
      Independent Ethics Committee or Institutional Review Board approval. RESULTS:
      During maintenance treatment, 70 of 646 patients (11%) discontinued because of
      adverse events (AEs), 69 of 646 (11%) because of withdrawn consent, and 57 of 646
      (9%) because of noncompliance. A total of 571 of 646 patients (88%) had one or
      more AEs; most were mild to moderate in intensity and typical of AEs associated
      with opioid use in a noncancer chronic pain population. Serious AEs were seen in 
      118 of 646 patients (18%); most were considered by the investigators to be
      unrelated or unlikely to be related to FBT. There were six deaths (three
      myocardial infarction, two cardiac arrest, and one pneumonia) that were
      considered by investigators to be unrelated or unlikely to be related to FBT.
      There were two reports of accidental overdose contained within nine reports of
      nonfatal overdose (FBT and/or ATC and/or other medications). Four patients had
      AEs of abuse or drug dependence, two in association with FBT. Drug withdrawal
      syndrome occurred in 23 patients after discontinuation of FBT alone or in
      combination with other opioids. Secondary assessments showed that average pain
      ratings, as assessed by the Brief Pain Inventory, remained relatively stable
      throughout the study and that consistent improvements were noted in functional
      measures. CONCLUSION: FBT was generally safe and well tolerated, with
      self-reported functional improvement observed in most of the opioid-tolerant
      patients with BTP in association with chronic noncancer pain.
CI  - Copyright (c) 2010 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. 
      All rights reserved.
FAU - Fine, Perry G
AU  - Fine PG
AD  - Department of Anesthesiology, Pain Management Center, Suite 200, 615 Arapeen
      Drive, University of Utah, Salt Lake City, UT 84109, USA. perry.fine@hsc.utah.edu
FAU - Messina, John
AU  - Messina J
FAU - Xie, Fang
AU  - Xie F
FAU - Rathmell, James
AU  - Rathmell J
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20100701
PL  - United States
TA  - J Pain Symptom Manage
JT  - Journal of pain and symptom management
JID - 8605836
RN  - 0 (Analgesics, Opioid)
RN  - UF599785JZ (Fentanyl)
SB  - IM
MH  - Administration, Buccal
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Analgesics, Opioid/administration & dosage/adverse effects
MH  - Chronic Disease/drug therapy
MH  - Female
MH  - Fentanyl/administration & dosage/*adverse effects
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pain/*drug therapy
MH  - Pain Measurement
MH  - *Patient Satisfaction
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
EDAT- 2010/07/03 06:00
MHDA- 2011/02/26 06:00
CRDT- 2010/07/03 06:00
PHST- 2009/12/21 00:00 [received]
PHST- 2010/02/16 00:00 [revised]
PHST- 2010/02/17 00:00 [accepted]
PHST- 2010/07/03 06:00 [entrez]
PHST- 2010/07/03 06:00 [pubmed]
PHST- 2011/02/26 06:00 [medline]
AID - S0885-3924(10)00390-8 [pii]
AID - 10.1016/j.jpainsymman.2010.02.009 [doi]
PST - ppublish
SO  - J Pain Symptom Manage. 2010 Nov;40(5):747-60. doi:
      10.1016/j.jpainsymman.2010.02.009. Epub 2010 Jul 1.


PMID- 20594387
OWN - NLM
STAT- MEDLINE
DCOM- 20110209
LR  - 20181201
IS  - 1741-203X (Electronic)
IS  - 1041-6102 (Linking)
VI  - 22
IP  - 8
DP  - 2010 Dec
TI  - What do cognitively intact older people think about the use of electronic
      tracking devices for people with dementia? A preliminary analysis.
PG  - 1301-9
LID - 10.1017/S1041610210001316 [doi]
AB  - BACKGROUND: The issue of using advanced tracking technologies such as Global
      Positioning Systems (GPS) is part of a wider debate on the acceptability of
      assistive technology to older people with dementia. The use of GPS can enhance
      the personal safety of older people by alerting caregivers to potential dangers
      or adverse events that might threaten the individual's health and safety, but at 
      the same time it raises ethical concerns. This study examines the attitudes of
      cognitively intact older people toward the use of tracking devices for people
      with dementia. METHODS: The analysis is based on quantitative data from a
      convenience sample (n = 42) and qualitative data gathered from two focus groups
      of cognitively intact older people in Israel. RESULTS: Whereas cognitively intact
      older people clearly differentiate between themselves and people with dementia,
      they support the use of tracking devices when dementia is either formally
      diagnosed or its signs are evident. They value the safety of people with dementia
      above preserving their autonomy. Although they perceive the decision to use
      tracking devices as an intra-family issue, they expect guidance from professional
      caregivers of people with dementia. The acceptability of tracking devices is
      dependent on their appropriate weight, size and ease of use. CONCLUSIONS:
      Cognitively intact older people favor the idea of tracking people with dementia. 
      To facilitate family decision-making on the use of tracking devices, structured
      meetings guided by professionals and including persons with dementia and their
      family caregivers are suggested.
FAU - Landau, Ruth
AU  - Landau R
AD  - Paul Baerwald School of Social Work and Social Welfare, The Hebrew University of 
      Jerusalem, Israel. mslanda@mscc.huji.ac.il
FAU - Werner, Shirli
AU  - Werner S
FAU - Auslander, Gail K
AU  - Auslander GK
FAU - Shoval, Noam
AU  - Shoval N
FAU - Heinik, Jeremia
AU  - Heinik J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100701
PL  - England
TA  - Int Psychogeriatr
JT  - International psychogeriatrics
JID - 9007918
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Caregivers/psychology
MH  - *Cognition
MH  - Decision Making
MH  - *Dementia/psychology/rehabilitation
MH  - Family
MH  - Female
MH  - Geographic Information Systems/instrumentation/*statistics & numerical data
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Israel
MH  - Male
MH  - Personal Autonomy
MH  - Safety Management/*methods/trends
MH  - Self-Help Devices/*psychology/*statistics & numerical data
EDAT- 2010/07/03 06:00
MHDA- 2011/02/10 06:00
CRDT- 2010/07/03 06:00
PHST- 2010/07/03 06:00 [entrez]
PHST- 2010/07/03 06:00 [pubmed]
PHST- 2011/02/10 06:00 [medline]
AID - S1041610210001316 [pii]
AID - 10.1017/S1041610210001316 [doi]
PST - ppublish
SO  - Int Psychogeriatr. 2010 Dec;22(8):1301-9. doi: 10.1017/S1041610210001316. Epub
      2010 Jul 1.


PMID- 20593907
OWN - NLM
STAT- MEDLINE
DCOM- 20110112
LR  - 20211020
IS  - 1179-2019 (Electronic)
IS  - 1174-5878 (Linking)
VI  - 12
IP  - 4
DP  - 2010 Aug 1
TI  - Understanding developmental pharmacodynamics: importance for drug development and
      clinical practice.
PG  - 223-33
LID - 10.2165/11319220-000000000-00000 [doi]
AB  - Developmental pharmacodynamics is the study of age-related maturation of the
      structure and function of biologic systems and how this affects response to
      pharmacotherapy. This may manifest as a change in the potency, efficacy, or
      therapeutic range of a drug. The paucity of studies exploring developmental
      pharmacodynamics reflects the lack of suitable juvenile animal models and the
      ethical and practical constraints of conducting studies in children. However,
      where data from animal models are available, valuable insight has been gained
      into how response to therapy can change through the course of development. For
      example, animal neurodevelopmental models have revealed that temporal differences
      in the maturation of norepinephrine and serotonin neurotransmitter systems may
      explain the lack of efficacy of some antidepressants in children. GABA(A)
      receptors that switch from an excitatory to inhibitory mode during early
      development help to explain paradoxical seizures experienced by infants after
      exposure to benzodiazepines. The increased sensitivity of neonates to morphine
      may be due to increased postnatal expression of the mu opioid receptor. An age
      dependency to the pharmacokinetic-pharmacodynamic relationship has also been
      found in some clinical studies. For example, immunosuppressive effects of
      ciclosporin (cyclosporine) revealed markedly enhanced sensitivity in infants
      compared with older children and adults. A study of sotalol in the treatment of
      children with supraventricular tachycardia showed that neonates exhibited a
      higher sensitivity towards QTc interval prolongation compared with older
      children. However, the data are limited and efforts to increase and establish
      data on developmental pharmacodynamics are necessary to achieve optimal drug
      therapy in children and to ensure long-term success of pediatric drug
      development. This requires a dual 'bottom up' (ontogeny knowledge driven) and
      'top down' (pediatric pharmacokinetic-pharmacodynamic studies) approach.
FAU - Mulla, Hussain
AU  - Mulla H
AD  - Centre for Therapeutic Evaluation of Drugs in Children, University Hospitals of
      Leicester, Leicester, UK. hussain.mulla@uhl-tr.nhs.uk
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Switzerland
TA  - Paediatr Drugs
JT  - Paediatric drugs
JID - 100883685
SB  - IM
MH  - Aging/*metabolism/physiology
MH  - Animals
MH  - Clinical Medicine/*methods
MH  - Dose-Response Relationship, Drug
MH  - Drug Discovery/*methods
MH  - Humans
MH  - *Pharmacokinetics
EDAT- 2010/07/03 06:00
MHDA- 2011/01/13 06:00
CRDT- 2010/07/03 06:00
PHST- 2010/07/03 06:00 [entrez]
PHST- 2010/07/03 06:00 [pubmed]
PHST- 2011/01/13 06:00 [medline]
AID - 2 [pii]
AID - 10.2165/11319220-000000000-00000 [doi]
PST - ppublish
SO  - Paediatr Drugs. 2010 Aug 1;12(4):223-33. doi: 10.2165/11319220-000000000-00000.


PMID- 20592823
OWN - NLM
STAT- MEDLINE
DCOM- 20100922
LR  - 20211020
IS  - 0008-5286 (Print)
IS  - 0008-5286 (Linking)
VI  - 51
IP  - 4
DP  - 2010 Apr
TI  - An ethicist's commentary on bad becoming normal in agriculture.
PG  - 352-3
FAU - Rollin, Bernard E
AU  - Rollin BE
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Vet J
JT  - The Canadian veterinary journal = La revue veterinaire canadienne
JID - 0004653
SB  - IM
MH  - Animal Husbandry/*ethics/*standards
MH  - Animal Welfare/*ethics
MH  - Animals
MH  - Canada
MH  - Disease Outbreaks/veterinary
MH  - Humans
MH  - Veterinarians/*ethics/psychology
PMC - PMC2839820
EDAT- 2010/07/02 06:00
MHDA- 2010/09/24 06:00
CRDT- 2010/07/02 06:00
PHST- 2010/07/02 06:00 [entrez]
PHST- 2010/07/02 06:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
PST - ppublish
SO  - Can Vet J. 2010 Apr;51(4):352-3.


PMID- 20592592
OWN - NLM
STAT- MEDLINE
DCOM- 20101122
LR  - 20100804
IS  - 1473-6578 (Electronic)
IS  - 0951-7367 (Linking)
VI  - 23
IP  - 5
DP  - 2010 Sep
TI  - Ethical issues in forensic psychiatry in penal and other correctional facilities.
PG  - 467-71
LID - 10.1097/YCO.0b013e32833bb2f2 [doi]
AB  - PURPOSE OF REVIEW: Forensic mental health practitioners, especially psychiatrists
      working in jails, prisons or other correctional facilities, face special problems
      that are unlike others encountered in bioethics. RECENT FINDINGS: Literature
      published during the past year shows that the forensic psychiatrist has to adhere
      to role clarity: as a physician, he is primarily obligated to the treatment and
      well being of the incarcerated patients and is not exclusively an agent of social
      control. Moreover, the general conditions in a therapeutic setting (e.g. dealing 
      with medical confidentiality) have to be clear and transparent to the patients.
      Different ethical models building a fitting framework for forensic practice are
      used. SUMMARY: Forensic psychiatric practice in penal and other correctional
      facilities poses particular ethical dilemmas. There is a great need for
      international humanitarian law, which serves both to protect vulnerable prisoners
      and to shield health professionals who treat prisoners with respect and dignity
      from abuse or penalty. It must be a common objective to find the right balance
      between protection from exploitation and access to research beneficial to
      prisoners.
FAU - Konrad, Norbert
AU  - Konrad N
AD  - Institute of Forensic Psychiatry, Charite - University Medicine Berlin, Berlin,
      Germany. norbert.konrad@charite.de
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Psychiatry
JT  - Current opinion in psychiatry
JID - 8809880
SB  - IM
MH  - Confidentiality/ethics
MH  - Empirical Research
MH  - Forensic Psychiatry/*ethics
MH  - Humans
MH  - Informed Consent/ethics
MH  - Mental Disorders/diagnosis/therapy
MH  - Physician's Role
MH  - Prisoners/psychology
MH  - Prisons/*ethics/organization & administration
EDAT- 2010/07/02 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/07/02 06:00
PHST- 2010/07/02 06:00 [entrez]
PHST- 2010/07/02 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1097/YCO.0b013e32833bb2f2 [doi]
PST - ppublish
SO  - Curr Opin Psychiatry. 2010 Sep;23(5):467-71. doi: 10.1097/YCO.0b013e32833bb2f2.


PMID- 20592539
OWN - NLM
STAT- MEDLINE
DCOM- 20101220
LR  - 20191210
IS  - 1539-0713 (Electronic)
IS  - 0884-741X (Linking)
VI  - 28
IP  - 7
DP  - 2010 Jul-Aug
TI  - The ethical balancing act of hospice care.
PG  - 407-13; quiz 413-5
LID - 10.1097/NHH.0b013e3181e325b8 [doi]
AB  - In providing hospice care, clinicians are confronted with ethical challenges on a
      daily basis involving their patients and families, their personal values and
      beliefs, and organizational practices. Being able to objectively understand these
      ethical challenges and having a plan of action to address is essential in
      effectively fulfilling the role of being a hospice professional.
FAU - Longenecker, Paul D
AU  - Longenecker PD
AD  - Business & Leadership Studies, Lourdes College, Sylvania, Ohio, 43560, USA.
      plongenecker@lourdes.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Home Healthc Nurse
JT  - Home healthcare nurse
JID - 8403379
MH  - Conflict, Psychological
MH  - Hospice Care/*ethics
MH  - Humans
MH  - Medical Futility/ethics
MH  - Principle-Based Ethics
MH  - Professional-Family Relations/ethics
MH  - Professional-Patient Relations/ethics
MH  - Social Values
MH  - Standard of Care/legislation & jurisprudence
MH  - Truth Disclosure/ethics
EDAT- 2010/07/02 06:00
MHDA- 2010/12/21 06:00
CRDT- 2010/07/02 06:00
PHST- 2010/07/02 06:00 [entrez]
PHST- 2010/07/02 06:00 [pubmed]
PHST- 2010/12/21 06:00 [medline]
AID - 10.1097/NHH.0b013e3181e325b8 [doi]
AID - 00004045-201007000-00005 [pii]
PST - ppublish
SO  - Home Healthc Nurse. 2010 Jul-Aug;28(7):407-13; quiz 413-5. doi:
      10.1097/NHH.0b013e3181e325b8.


PMID- 20592414
OWN - NLM
STAT- MEDLINE
DCOM- 20101008
LR  - 20190709
IS  - 1943-4723 (Electronic)
IS  - 0002-8177 (Linking)
VI  - 141
IP  - 7
DP  - 2010 Jul
TI  - What is my ethical responsibility toward patients who refuse to be treated with
      materials containing fluoride?
PG  - 906-8
FAU - Gamba, Thomas W
AU  - Gamba TW
AD  - American Dental Association Council on Ethics, Bylaws and Judicial Affairs, 211
      E. Chicago Ave., Chicago, IL 60611, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Am Dent Assoc
JT  - Journal of the American Dental Association (1939)
JID - 7503060
RN  - 0 (Cariostatic Agents)
RN  - Q80VPU408O (Fluorides)
SB  - IM
MH  - American Dental Association
MH  - Cariostatic Agents/*administration & dosage
MH  - Codes of Ethics
MH  - Disclosure/*ethics
MH  - *Ethics, Dental
MH  - Fluorides/*administration & dosage
MH  - Humans
MH  - Patient Rights
MH  - Treatment Refusal/*ethics
MH  - United States
EDAT- 2010/07/02 06:00
MHDA- 2010/10/12 06:00
CRDT- 2010/07/02 06:00
PHST- 2010/07/02 06:00 [entrez]
PHST- 2010/07/02 06:00 [pubmed]
PHST- 2010/10/12 06:00 [medline]
AID - 141/7/906 [pii]
AID - 10.14219/jada.archive.2010.0292 [doi]
PST - ppublish
SO  - J Am Dent Assoc. 2010 Jul;141(7):906-8. doi: 10.14219/jada.archive.2010.0292.


PMID- 20591712
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20100927
IS  - 1887-1364 (Electronic)
IS  - 1134-282X (Linking)
VI  - 25
IP  - 5
DP  - 2010 Sep-Oct
TI  - [Assessment and learning from the 27th Conference of the Spanish Society for
      quality in healthcare].
PG  - 301-7
LID - 10.1016/j.cali.2010.05.004 [doi]
AB  - OBJECTIVE: To analyse the results of the 27th Conference of the Spanish Society
      for Quality in Health Care (SECA) held in Seville (October 2009). MATERIAL AND
      METHODS: A retrospective descriptive study was conducted using the conference
      databases. POPULATION: All abstracts received (1231). 36 pairs of reviewers using
      explicit criteria evaluated abstracts and assignment as Experiences or Electronic
      Communications. Participant satisfaction in the Conference and Workshops was
      evaluated by an anonymous questionnaire. RESULTS: A total of 1213 communications 
      were accepted. The average score of accepted abstracts was 6.38 +/- 0.95 points. 
      Experiences had an average score of 7.55 +/- 0.41 points, while Electronic
      Abstracts had an average score of 6.26 +/- 0.9 points. Andalusia (557) and
      Catalonia (140) had the highest amount of abstracts in the Conference, but Murcia
      and Andalusia obtained the highest rates per million inhabitants. CONCLUSIONS:
      The assessment of abstracts and organising a national conference are
      methodologically complex processes. Accountability for actions and decisions made
      by the Organising and Scientific Committees are an ethical requirement of
      transparency.
CI  - Copyright (c) 2010 SECA. Published by Elsevier Espana. All rights reserved.
FAU - Reyes-Alcazar, V
AU  - Reyes-Alcazar V
AD  - Comite Cientifico del 27 Congreso de la Sociedad Espanola de Calidad Asistencial,
      Sevilla, Espana. victor.reyes@juntadeandalucia.es
FAU - Torres-Olivera, A
AU  - Torres-Olivera A
FAU - Suarez-Aleman, G
AU  - Suarez-Aleman G
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Evaluacion y aprendizaje del 27 Congreso de la Sociedad Espanola de Calidad
      Asistencial.
DEP - 20100629
PL  - Spain
TA  - Rev Calid Asist
JT  - Revista de calidad asistencial : organo de la Sociedad Espanola de Calidad
      Asistencial
JID - 9601664
SB  - IM
MH  - Congresses as Topic
MH  - *Quality of Health Care
MH  - Societies, Scientific
MH  - Spain
EDAT- 2010/07/02 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/07/02 06:00
PHST- 2010/02/23 00:00 [received]
PHST- 2010/05/03 00:00 [revised]
PHST- 2010/05/10 00:00 [accepted]
PHST- 2010/07/02 06:00 [entrez]
PHST- 2010/07/02 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - S1134-282X(10)00076-X [pii]
AID - 10.1016/j.cali.2010.05.004 [doi]
PST - ppublish
SO  - Rev Calid Asist. 2010 Sep-Oct;25(5):301-7. doi: 10.1016/j.cali.2010.05.004. Epub 
      2010 Jun 29.


PMID- 20591631
OWN - NLM
STAT- MEDLINE
DCOM- 20101124
LR  - 20100802
IS  - 1769-664X (Electronic)
IS  - 0929-693X (Linking)
VI  - 17
IP  - 8
DP  - 2010 Aug
TI  - [The out-of-home care of HIV-infected children].
PG  - 1139-46
LID - 10.1016/j.arcped.2010.05.010 [doi]
AB  - OBJECTIVE: To improve the conditions of out-of-home care of HIV-infected
      children. METHODS: Group discussions including staff members of 28 institutions
      having cared for an HIV-infected child with the objective to share 4 points of
      view: those of the HIV-infected child, of his parents, of the medical staff and
      of the out-of-home care professionals. RESULTS: Care professionals are
      uncomfortable with the confidentiality surrounding the diagnosis. The feeling of 
      better controlling the risks justifies their wish to obtain medical information, 
      although these risks are ill-defined. The contributions of the parents of
      HIV-infected children shed a light on the link between the disclosure of the
      child's diagnosis and their intimacy and family history. Role-playing games with 
      constructed scenarios revealed fixed and absurd aspects of certain beliefs and
      the difficulties to put in practice the acquired knowledge. The legitimacy of
      desire of parenthood in HIV-infected adults was questioned by some of the care
      professionals and their social representation of the person living with HIV
      appeared ambiguous, reminding the stigma these families are still victims of.
      CONCLUSION: Improving the conditions of out-of-home care of HIV-infected children
      requires ethical, legal and scientific counseling and discussions in the setting 
      that should occur independently of the presence of a child with HIV. The
      disclosure of the diagnosis should only occur, if necessary, for their
      well-being, with their or their parents' agreement.
CI  - Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
FAU - Vanthournout, B
AU  - Vanthournout B
AD  - Centre pediatrique de reference sida, CHU Saint-Pierre, universite Libre de
      Bruxelles (ULB), 322, rue Haute, 1000 Bruxelles, Belgium.
      brigitte_vanthournout@stpierre-bru.be
FAU - Cornet, F
AU  - Cornet F
FAU - Lecroart, M-C
AU  - Lecroart MC
FAU - Van Der Kelen, E
AU  - Van Der Kelen E
FAU - Levy, J
AU  - Levy J
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - L'accueil de l'enfant infecte par le VIH dans le milieu scolaire et residentiel.
DEP - 20100629
PL  - France
TA  - Arch Pediatr
JT  - Archives de pediatrie : organe officiel de la Societe francaise de pediatrie
JID - 9421356
SB  - IM
MH  - Adult
MH  - Child
MH  - Confidentiality
MH  - Female
MH  - HIV Infections/psychology/*therapy
MH  - Home Care Services/standards
MH  - Humans
MH  - Institutionalization/standards
MH  - Male
MH  - Medical History Taking
MH  - Parent-Child Relations
MH  - Role Playing
MH  - Truth Disclosure
EDAT- 2010/07/02 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/07/02 06:00
PHST- 2009/12/07 00:00 [received]
PHST- 2010/05/24 00:00 [accepted]
PHST- 2010/07/02 06:00 [entrez]
PHST- 2010/07/02 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S0929-693X(10)00233-2 [pii]
AID - 10.1016/j.arcped.2010.05.010 [doi]
PST - ppublish
SO  - Arch Pediatr. 2010 Aug;17(8):1139-46. doi: 10.1016/j.arcped.2010.05.010. Epub
      2010 Jun 29.


PMID- 20591194
OWN - NLM
STAT- MEDLINE
DCOM- 20130214
LR  - 20211020
IS  - 1471-2458 (Electronic)
IS  - 1471-2458 (Linking)
VI  - 10
DP  - 2010 Jun 30
TI  - 'Relief of oppression': an organizing principle for researchers' obligations to
      participants in observational studies in the developing world.
PG  - 384
LID - 10.1186/1471-2458-10-384 [doi]
AB  - BACKGROUND: A central question in the debate about exploitation in international 
      research is whether investigators and sponsors from high-income countries (HIC)
      have obligations to address background conditions of injustice in the communities
      in which they conduct their research, beyond the healthcare and other
      research-related needs of participants, to aspects of their basic life
      circumstances. DISCUSSION: In this paper, we describe the Majengo sexually
      transmitted disease (STD) Cohort study, a long-term prospective, observational
      cohort of sex workers in Nairobi, Kenya. Despite important scientific
      contributions and a wide range of benefits to the women of the cohort, most of
      the women have remained in the sex trade during their long-standing participation
      in the cohort, prompting allegations of exploitation. The Majengo STD cohort case
      extends the debate about justice in international research ethics beyond clinical
      trials into long-term observational research. We sketch the basic features of a
      new approach to understanding and operationalizing obligations of observational
      researchers, which we call 'relief of oppression'. 'Relief of oppression' is an
      organizing principle, analogous to the principle of harm reduction that is now
      widely applied in public health practice. Relief of oppression aims to help
      observational researchers working in conditions of injustice and deprivation to
      clarify their ethical obligations to participants. It aims to bridge the gap
      between a narrow, transaction-oriented account of avoiding exploitation and a
      broad account emphasizing obligations of reparation for historic injustices. We
      propose that relief of oppression might focus researchers' consideration of
      benefits on those that have some relevance to background conditions of injustice,
      and so elevate the priority of these benefits, in relation to others that might
      be considered and negotiated with participants, according to the degree to which 
      the participating communities are constrained in their realization of fundamental
      freedoms. SUMMARY: The over-arching aim of relief of oppression is that, within
      the range of benefits negotiated over time with the local communities and
      organizations, an increasing proportion reflects a shared interest in improving
      participants' fundamental freedoms. We describe how harm reduction serves as a
      useful analogy for how we envision relief of oppression functioning in
      international research.
FAU - Lavery, James V
AU  - Lavery JV
AD  - Centre for Research on Inner City Health & Centre for Global Health Research,
      Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, 
      Toronto, Canada. jim.lavery@utoronto.ca
FAU - Bandewar, Sunita V S
AU  - Bandewar SV
FAU - Kimani, Joshua
AU  - Kimani J
FAU - Upshur, Ross E G
AU  - Upshur RE
FAU - Plummer, Frances A
AU  - Plummer FA
FAU - Singer, Peter A
AU  - Singer PA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100630
PL  - England
TA  - BMC Public Health
JT  - BMC public health
JID - 100968562
SB  - IM
MH  - Cohort Studies
MH  - *Developing Countries
MH  - Female
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Kenya
MH  - *Observation
MH  - Research Personnel/ethics
MH  - Sex Workers
MH  - *Sexually Transmitted Diseases
MH  - *Social Justice
PMC - PMC3091550
EDAT- 2010/07/02 06:00
MHDA- 2013/02/15 06:00
CRDT- 2010/07/02 06:00
PHST- 2010/01/01 00:00 [received]
PHST- 2010/06/30 00:00 [accepted]
PHST- 2010/07/02 06:00 [entrez]
PHST- 2010/07/02 06:00 [pubmed]
PHST- 2013/02/15 06:00 [medline]
AID - 1471-2458-10-384 [pii]
AID - 10.1186/1471-2458-10-384 [doi]
PST - epublish
SO  - BMC Public Health. 2010 Jun 30;10:384. doi: 10.1186/1471-2458-10-384.


PMID- 20591168
OWN - NLM
STAT- MEDLINE
DCOM- 20101028
LR  - 20211020
IS  - 1824-7288 (Electronic)
IS  - 1720-8424 (Linking)
VI  - 36
DP  - 2010 Jun 30
TI  - The FIMP Medicines for Children Research Network.
PG  - 46
LID - 10.1186/1824-7288-36-46 [doi]
AB  - The European Paediatric Regulation (EUPR) calls for the fostering of high quality
      ethical research and medicinal products to be used in children. The EUPR provides
      the background, goals, and requirements for paediatric clinical trials.
      Paediatric clinical trials in children are mandatory to generate data on new
      drugs as well as on drugs used off-label or for unlicensed indications. The
      Family Paediatricians Medicines for Children Research Network (FIMP-MCRN) was
      established in 2003 with the aim of developing competence, infrastructure,
      networking and education for paediatric clinical trials. The network, consisting 
      of twenty Paediatric Regional Networks has progressed very well and has achieved 
      valuable improvements concerning the conduct of paediatric clinical trials.
      Furthermore, ad hoc training programs have incremented knowledge about clinical
      trials in Family Paediatrician Investigators (FPI) and have made medical
      professionals as well as the public aware of the need and advantages of trials in
      children.
FAU - Napoleone, Ettore
AU  - Napoleone E
AD  - Indirizzo: Piazza della Vittoria 14/A, Campobasso 86100, Italia.
      ettorenapoleone@tiscali.it
FAU - Mele, Giuseppe
AU  - Mele G
LA  - eng
PT  - Editorial
DEP - 20100630
PL  - England
TA  - Ital J Pediatr
JT  - Italian journal of pediatrics
JID - 101510759
SB  - IM
MH  - Biomedical Research/*organization & administration
MH  - Child
MH  - Family Practice/*methods
MH  - Humans
MH  - Italy
MH  - Pediatrics/*methods
MH  - *Physicians, Family
PMC - PMC2909954
EDAT- 2010/07/02 06:00
MHDA- 2010/10/29 06:00
CRDT- 2010/07/02 06:00
PHST- 2010/03/04 00:00 [received]
PHST- 2010/06/30 00:00 [accepted]
PHST- 2010/07/02 06:00 [entrez]
PHST- 2010/07/02 06:00 [pubmed]
PHST- 2010/10/29 06:00 [medline]
AID - 1824-7288-36-46 [pii]
AID - 10.1186/1824-7288-36-46 [doi]
PST - epublish
SO  - Ital J Pediatr. 2010 Jun 30;36:46. doi: 10.1186/1824-7288-36-46.


PMID- 20590680
OWN - NLM
STAT- MEDLINE
DCOM- 20100929
LR  - 20220317
IS  - 1752-8062 (Electronic)
IS  - 1752-8054 (Linking)
VI  - 3
IP  - 3
DP  - 2010 Jun
TI  - Instruction in the responsible conduct of research: an inventory of programs and 
      materials within CTSAs.
PG  - 109-11
LID - 10.1111/j.1752-8062.2010.00193.x [doi]
AB  - The National Institutes of Health (NIH) require instruction in the responsible
      conduct of research (RCR) as a component of any Clinical and Translational
      Science Award (CTSA). The Educational Materials Group of the NIH CTSA
      Consortium's Clinical Research Ethics Key Function Committee (CRE-KFC) conducted 
      a survey of the 38 institutions that held CTSA funding as of January 2009 to
      determine how they satisfy RCR training requirements. An 8-item questionnaire was
      sent by email to directors of the Clinical Research Ethics, the Educational and
      Career Development, and the Regulatory Knowledge cores. We received 78 completed 
      surveys from 38 CTSAs (100%). We found that there is no unified approach to RCR
      training across CTSAs, many programs lack a coherent plan for RCR instruction,
      and most CTSAs have not developed unique instructional materials tailored to the 
      needs of clinical and translational scientists. We recommend collaboration among 
      CTSAs and across CTSA key function committees to address these weaknesses. We
      also requested that institutions send electronic copies of original RCR training 
      materials to share among CTSAs via the CTSpedia website. Twenty institutions
      submitted at least one educational product. The CTSpedia now contains more than
      90 RCR resources.
FAU - DuBois, James M
AU  - DuBois JM
AD  - Department of Medicine, Center for Clinical Research Ethics at Washington
      University School of Medicine and Albert Gnaegi Center for Health Care Ethics at 
      Saint Louis University, Missouri, USA. duboisjm@slu.edu
FAU - Schilling, Debie A
AU  - Schilling DA
FAU - Heitman, Elizabeth
AU  - Heitman E
FAU - Steneck, Nicholas H
AU  - Steneck NH
FAU - Kon, Alexander A
AU  - Kon AA
LA  - eng
GR  - UL1 RR024992/RR/NCRR NIH HHS/United States
GR  - 1UL1 RR024975/RR/NCRR NIH HHS/United States
GR  - UL1 TR000448/TR/NCATS NIH HHS/United States
GR  - UL1 RR024975/RR/NCRR NIH HHS/United States
GR  - 1UL1 RR024986-01/RR/NCRR NIH HHS/United States
GR  - UL1 RR024986/RR/NCRR NIH HHS/United States
GR  - UL1 RR024992-017805/RR/NCRR NIH HHS/United States
GR  - UL1 RR024146-03S2/RR/NCRR NIH HHS/United States
GR  - 3UL1RR024146-03S2/RR/NCRR NIH HHS/United States
GR  - UL1 RR024146/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Clin Transl Sci
JT  - Clinical and translational science
JID - 101474067
SB  - IM
MH  - *Awards and Prizes
MH  - *Curriculum
MH  - Data Collection
MH  - Ethics, Research/*education
MH  - Surveys and Questionnaires
MH  - Textbooks as Topic
MH  - Translational Research, Biomedical/*education/*ethics
PMC - PMC2898747
MID - NIHMS197678
EDAT- 2010/07/02 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/07/02 06:00
PHST- 2010/07/02 06:00 [entrez]
PHST- 2010/07/02 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - CTS193 [pii]
AID - 10.1111/j.1752-8062.2010.00193.x [doi]
PST - ppublish
SO  - Clin Transl Sci. 2010 Jun;3(3):109-11. doi: 10.1111/j.1752-8062.2010.00193.x.


PMID- 20590495
OWN - NLM
STAT- MEDLINE
DCOM- 20100817
LR  - 20151119
IS  - 0003-1488 (Print)
IS  - 0003-1488 (Linking)
VI  - 237
IP  - 1
DP  - 2010 Jul 1
TI  - Faculty perspectives regarding the importance and place of nontechnical
      competencies in veterinary medical education at five North American colleges of
      veterinary medicine.
PG  - 53-64
LID - 10.2460/javma.237.1.53 [doi]
AB  - OBJECTIVE: To explore perceptions of faculty educators regarding the importance
      of nontechnical competencies in veterinary graduates and the placement of
      nontechnical competency development in veterinary education. DESIGN: Survey.
      SAMPLE POPULATION: All faculty members at 5 North American veterinary medical
      institutions. PROCEDURES: Participants rated the importance of 14 nontechnical
      competencies and indicated in which phase or phases of veterinary education such 
      competencies should be developed (ie, curriculum placement). Differences in mean 
      ratings were statistically evaluated, as were associations between ratings or
      curriculum placement and respondent institution, gender, experience, and
      discipline. RESULTS: Mean ratings of importance were above neutral for all
      competencies and were highest for ethical, critical thinking, and interpersonal
      and intrapersonal competencies; development of these competencies was favored in 
      preveterinary and veterinary training. Ratings were lower for management and
      business competencies; development of these and other competencies was placed
      primarily in the clinical phase of the veterinary curriculum. Basic science,
      nonveterinarian, and junior faculty appeared to more strongly appreciate the
      importance of nontechnical skills, whereas large animal and midcareer faculty
      reported a more reserved degree of support. Female faculty were more likely to
      place nontechnical competency development throughout the educational process.
      CONCLUSIONS AND CLINICAL RELEVANCE: Participants agreed nontechnical competencies
      are important for veterinary graduates; however, faculty perceptions differed
      from previously published findings regarding the relative importance of business 
      and management skills. Those involved in faculty hiring, faculty development, and
      curricular planning should also be aware of disciplinary and career stage
      differences affecting faculty perspectives.
FAU - Lane, India F
AU  - Lane IF
AD  - Department of Small Animal Clinical Sciences, College of Veterinary Medicine,
      University of Tennessee, Knoxville, TN 37996, USA. ilane@utk.edu
FAU - Bogue, E Grady
AU  - Bogue EG
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Vet Med Assoc
JT  - Journal of the American Veterinary Medical Association
JID - 7503067
SB  - IM
MH  - Canada
MH  - Data Collection
MH  - Education, Veterinary/*standards/*trends
MH  - *Faculty
MH  - Female
MH  - Humans
MH  - Male
MH  - Professional Competence/*standards
MH  - Surveys and Questionnaires
MH  - United States
MH  - Veterinary Medicine/*trends
EDAT- 2010/07/02 06:00
MHDA- 2010/08/18 06:00
CRDT- 2010/07/02 06:00
PHST- 2010/07/02 06:00 [entrez]
PHST- 2010/07/02 06:00 [pubmed]
PHST- 2010/08/18 06:00 [medline]
AID - 10.2460/javma.237.1.53 [doi]
PST - ppublish
SO  - J Am Vet Med Assoc. 2010 Jul 1;237(1):53-64. doi: 10.2460/javma.237.1.53.


PMID- 20590052
OWN - NLM
STAT- MEDLINE
DCOM- 20100727
LR  - 20100701
IS  - 0193-7758 (Print)
IS  - 0193-7758 (Linking)
VI  - 32
IP  - 3
DP  - 2010 May-Jun
TI  - Canadian research ethics boards and multisite research: experiences from two
      minimal-risk studies.
PG  - 12-8
FAU - Racine, Eric
AU  - Racine E
AD  - Neuroethics Rearch Unit, Institut de recherches cliniques de Montreal, QC,
      Canada.
FAU - Bell, Emily
AU  - Bell E
FAU - Deslauriers, Constance
AU  - Deslauriers C
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - IRB
JT  - IRB
JID - 7906878
SB  - IM
MH  - Canada
MH  - *Efficiency, Organizational
MH  - Ethics Committees, Research/*organization & administration
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Multicenter Studies as Topic/*ethics
EDAT- 2010/07/02 06:00
MHDA- 2010/07/28 06:00
CRDT- 2010/07/02 06:00
PHST- 2010/07/02 06:00 [entrez]
PHST- 2010/07/02 06:00 [pubmed]
PHST- 2010/07/28 06:00 [medline]
PST - ppublish
SO  - IRB. 2010 May-Jun;32(3):12-8.


PMID- 20589537
OWN - NLM
STAT- MEDLINE
DCOM- 20120330
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 17
IP  - 3
DP  - 2011 Sep
TI  - Facilitating ethical reflection among scientists using the ethical matrix.
PG  - 425-45
LID - 10.1007/s11948-010-9218-2 [doi]
AB  - Several studies have indicated that scientists are likely to have an outlook on
      both facts and values that are different to that of lay people in important ways.
      This is one significant reason it is currently believed that in order for
      scientists to exercise a reliable ethical reflection about their research it is
      necessary for them to engage in dialogue with other stakeholders. This paper
      reports on an exercise to encourage a group of scientists to reflect on ethical
      issues without the presence of external stakeholders. It reports on the use of a 
      reflection process with scientists working in the area of animal disease genomics
      (mainly drawn from the EADGENE EC Network of Excellence). This reflection process
      was facilitated by using an ethical engagement framework, a modified version of
      the Ethical Matrix. As judged by two criteria, a qualitative assessment of the
      outcomes and the participants' own assessment of the process, this independent
      reflective exercise was deemed to be successful. The discussions demonstrated a
      high level of complexity and depth, with participants demonstrating a clear
      perception of uncertainties and the context in which their research operates.
      Reflection on stakeholder views and values appeared to be embedded within the
      discussions. The finding from this exercise seems to indicate that even without
      the involvement of the wider stakeholder community, valuable reflection and
      worthwhile discourse can be generated from ethical reflection processes involving
      only scienitific project partners. Hence, the previous assumption that direct
      stakeholder engagement is necessary for ethical reflection does not appear to
      hold true in all cases; however, other reasons for involving a broad group of
      stakeholders relating to governance and social accountability of science remain.
FAU - Jensen, Karsten Klint
AU  - Jensen KK
AD  - Danish Centre for Bioethics and Risk Assessment, Faculty of Life Sciences,
      University of Copenhagen, Rolighedsvej 25, 1958, Frederiksberg C, Denmark.
      kkje@life.ku.dk
FAU - Forsberg, Ellen-Marie
AU  - Forsberg EM
FAU - Gamborg, Christian
AU  - Gamborg C
FAU - Millar, Kate
AU  - Millar K
FAU - Sandoe, Peter
AU  - Sandoe P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100630
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Animals
MH  - *Attitude
MH  - *Bioethical Issues
MH  - *Ethics, Research
MH  - Genomics/*ethics
MH  - Group Processes
MH  - Humans
MH  - Perception
MH  - Residence Characteristics
MH  - *Social Responsibility
MH  - Social Values
MH  - Uncertainty
EDAT- 2010/07/01 06:00
MHDA- 2012/03/31 06:00
CRDT- 2010/07/01 06:00
PHST- 2010/03/15 00:00 [received]
PHST- 2010/06/01 00:00 [accepted]
PHST- 2010/07/01 06:00 [entrez]
PHST- 2010/07/01 06:00 [pubmed]
PHST- 2012/03/31 06:00 [medline]
AID - 10.1007/s11948-010-9218-2 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2011 Sep;17(3):425-45. doi: 10.1007/s11948-010-9218-2. Epub 2010 
      Jun 30.


PMID- 20589364
OWN - NLM
STAT- MEDLINE
DCOM- 20110803
LR  - 20100630
IS  - 1972-6007 (Electronic)
IS  - 0009-9074 (Linking)
VI  - 161
IP  - 3
DP  - 2010
TI  - Ethics committees.
PG  - 281-3
AB  - Ethics committees (ECs) are a relevant body for dealing with ethical issues in
      healthcare. They born in order to resolve dilemmatic situations. Contemporary ECs
      are independent standing committees with multidisciplinary representation,
      including medicine, nursing, social work, law, pastoral care, healthcare
      administration, and other different expertises. The functions of ECs are various:
      estimating clinical trials; analyzing ethically relevant clinical cases; drafting
      hospital/organizational guidelines, and to carry out education activity. The
      composition and kind of skills requested in an EC could change according to
      national laws. About international ethical standards in clinical experimentation,
      the World Medical Association's Declaration of Helsinki is the reference
      according to which examining clinical trials by ECs.
FAU - Sacchini, D
AU  - Sacchini D
AD  - Institute of Bioethics, A. Gemelli School of Medicine, Universita Cattolica del
      Sacro Cuore, Rome, Italy.
FAU - Pennacchini, M
AU  - Pennacchini M
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Clin Ter
JT  - La Clinica terapeutica
JID - 0372604
SB  - IM
MH  - *Ethics Committees
MH  - Terminology as Topic
EDAT- 2010/07/01 06:00
MHDA- 2011/08/04 06:00
CRDT- 2010/07/01 06:00
PHST- 2010/07/01 06:00 [entrez]
PHST- 2010/07/01 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
PST - ppublish
SO  - Clin Ter. 2010;161(3):281-3.


PMID- 20589351
OWN - NLM
STAT- MEDLINE
DCOM- 20110803
LR  - 20100630
IS  - 1972-6007 (Electronic)
IS  - 0009-9074 (Linking)
VI  - 161
IP  - 3
DP  - 2010
TI  - [Informed consent. Doctor and patient: comparison of view points].
PG  - 227-30
AB  - Starting with an examination of the ethical and legal need for informed consent, 
      the authors set out to assess the perception of the issue by physicians and
      patients, with particular reference to the Italian context, but also in
      comparison with international experience, which emerges from an analysis of the
      heterogeneous material on the Internet. Regardless of local laws, there seems to 
      be a substantial overlap between the way in which the Italian community of
      doctors and patients and the international community experience informed consent,
      which often is not the assurance of an effective therapeutic relationship that we
      would like it to be.
FAU - Felicetti, V
AU  - Felicetti V
FAU - Manfredi Selvaggi, F
AU  - Manfredi Selvaggi F
FAU - Cifaldi, L
AU  - Cifaldi L
LA  - ita
PT  - Comparative Study
PT  - Editorial
PT  - English Abstract
TT  - Consenso informato. Medico e paziente: punti di vista a confronto.
PL  - Italy
TA  - Clin Ter
JT  - La Clinica terapeutica
JID - 0372604
SB  - IM
MH  - Attitude
MH  - Humans
MH  - *Informed Consent
MH  - *Patients
MH  - *Physicians
EDAT- 2010/07/01 06:00
MHDA- 2011/08/04 06:00
CRDT- 2010/07/01 06:00
PHST- 2010/07/01 06:00 [entrez]
PHST- 2010/07/01 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
PST - ppublish
SO  - Clin Ter. 2010;161(3):227-30.


PMID- 20589195
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1738-5555 (Electronic)
IS  - 1738-5520 (Linking)
VI  - 40
IP  - 6
DP  - 2010 Jun
TI  - Sudden death in pediatric populations.
PG  - 253-7
LID - 10.4070/kcj.2010.40.6.253 [doi]
AB  - Sudden death (SD) in children is rarer than in adults. In the pediatric
      population, SD accounts for less than one tenth of deaths from all causes. SD in 
      infants is a separate entity commonly termed "sudden infant death syndrome
      (SIDS)". Previous studies on SD in pediatric patients primarily focused on
      infants and showed that the incidence of SIDS was much lower in Asian countries
      than in Western ones. However, these differences diminished after educational
      campaigns such as the back to sleep act in the late 1980s to early 1990s. The
      incidence of SIDS from Western reports has decreased from 2.69 to around 0.5-0.24
      per 1,000 live births. Beyond infancy, the annual incidence of SD ranges from 1.3
      to 7.5 per 100,000. In 2009, two population-based studies, one from Taiwan and
      the other from the US, explored the epidemiological profile of SD in children.
      The child health care indexes of these two countries are similar, but the annual 
      incidence of pediatric SD was 7.5 and 2.7 per 100,000 in the USA and Taiwan,
      respectively. The implications of ethic-related differences requires further
      confirmation. Around 40% of pediatric SD could be from cardiac causes, either
      diagnosed or undiagnosed. Risk stratification for cardiac SD and patient
      selection for implantable cardioverter-defibrillator (ICD) therapy are
      recommended. However, the adoption of ICD as primary prevention for SD in
      children is still a challenging issue. Early detection of undiagnosed cardiac
      risk may be facilitated by cardiac screening either in newborns or the school-age
      population to better manage the risk of SD. However, the efficacy of such
      screening remains still controversial.
FAU - Wu, Mei-Hwan
AU  - Wu MH
AD  - Department of Pediatrics, National Taiwan University Hospital, College of
      Medicine, National Taiwan University, Taipei, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20100629
PL  - Korea (South)
TA  - Korean Circ J
JT  - Korean circulation journal
JID - 101247141
PMC - PMC2893363
OTO - NOTNLM
OT  - Children
OT  - Infant
OT  - Sudden death
EDAT- 2010/07/01 06:00
MHDA- 2010/07/01 06:01
CRDT- 2010/07/01 06:00
PHST- 2010/07/01 06:00 [entrez]
PHST- 2010/07/01 06:00 [pubmed]
PHST- 2010/07/01 06:01 [medline]
AID - 10.4070/kcj.2010.40.6.253 [doi]
PST - ppublish
SO  - Korean Circ J. 2010 Jun;40(6):253-7. doi: 10.4070/kcj.2010.40.6.253. Epub 2010
      Jun 29.


PMID- 20588076
OWN - NLM
STAT- MEDLINE
DCOM- 20101005
LR  - 20211028
IS  - 1662-8063 (Electronic)
IS  - 1662-4246 (Linking)
VI  - 13
IP  - 5
DP  - 2010
TI  - Myths, misconceptions and myopia: searching for clarity in the debate about the
      regulation of consumer genetics.
PG  - 322-6
LID - 10.1159/000313330 [doi]
AB  - The new wave of companies offering genome scans direct-to-consumer (DTC) has
      prompted commentary from scientists, clinicians, bioethicists and those
      interested in the ethical, legal and social issues arising from genomics. It has 
      thus brought a far wider range of actors into a longstanding debate about the
      regulation of genetic tests. However, some of the recent discussion is
      characterised by misunderstanding of the regulatory landscape, a failure to grasp
      the lessons of the past and lack of clarity of thought. In this commentary I
      challenge a series of myths and misconceptions which plague current academic and 
      policy discussion: the conflation of regulation and proscription; the failure to 
      recognise that DTC companies are gatekeepers; the assumption that requiring a
      medical intermediary for testing is paternalistic; the belief that online
      services cannot be regulated; the presumption that we must avoid genetic
      exceptionalism; the idea that policy is lagging behind science or that it is too 
      soon to act; and finally, the view that DTC genetics is a reality we have to
      adapt to.
FAU - Hogarth, S
AU  - Hogarth S
AD  - Global Biopolitics Research Group, King's College London, London, UK.
      stuart.hogarth @ kcl.ac.uk
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100625
PL  - Switzerland
TA  - Public Health Genomics
JT  - Public health genomics
JID - 101474167
SB  - IM
MH  - Ethics, Medical
MH  - Humans
MH  - Myopia/*genetics
MH  - *Precision Medicine
PMC - PMC2914358
EDAT- 2010/07/01 06:00
MHDA- 2010/10/06 06:00
CRDT- 2010/07/01 06:00
PHST- 2010/02/23 00:00 [received]
PHST- 2010/04/09 00:00 [accepted]
PHST- 2010/07/01 06:00 [entrez]
PHST- 2010/07/01 06:00 [pubmed]
PHST- 2010/10/06 06:00 [medline]
AID - 000313330 [pii]
AID - 10.1159/000313330 [doi]
PST - ppublish
SO  - Public Health Genomics. 2010;13(5):322-6. doi: 10.1159/000313330. Epub 2010 Jun
      25.


PMID- 20587829
OWN - NLM
STAT- MEDLINE
DCOM- 20101013
LR  - 20100630
IS  - 1512-0112 (Print)
IS  - 1512-0112 (Linking)
IP  - 182
DP  - 2010 May
TI  - [The development of bioethics as a scientific discipline and the essence of
      bioethics].
PG  - 25-31
AB  - The author examines the patterns and predictors of newly emerging branch of
      science such as bioethics that originated on the background of a revolutionary
      situation in the history of biomedicine as the need for a new ethic that would
      confront the challenges brought about by scientific and technological development
      to humanity. Exploring many different kinds of bioethics issues, the author
      concludes that the essence of bioethics is that it is not only a scientific and
      practical discipline, but it is also a weltanschauung. Only with such an approach
      the spectrum of functions inherent in bioethics is expanded.
FAU - Arkhimandrit Adam Akhaladze, V M
AU  - Arkhimandrit Adam Akhaladze VM
LA  - rus
PT  - English Abstract
PT  - Historical Article
PT  - Journal Article
PL  - Georgia (Republic)
TA  - Georgian Med News
JT  - Georgian medical news
JID - 101218222
SB  - IM
MH  - *Bioethical Issues
MH  - Bioethics/*trends
MH  - Georgia (Republic)
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Morals
MH  - Philosophy
EDAT- 2010/07/01 06:00
MHDA- 2010/10/14 06:00
CRDT- 2010/07/01 06:00
PHST- 2010/07/01 06:00 [entrez]
PHST- 2010/07/01 06:00 [pubmed]
PHST- 2010/10/14 06:00 [medline]
PST - ppublish
SO  - Georgian Med News. 2010 May;(182):25-31.


PMID- 20587754
OWN - NLM
STAT- MEDLINE
DCOM- 20101025
LR  - 20120424
IS  - 1545-7206 (Electronic)
IS  - 0033-3182 (Linking)
VI  - 51
IP  - 4
DP  - 2010 Jul-Aug
TI  - Do-not-resuscitate orders in suicidal patients: clinical, ethical, and legal
      dilemmas.
PG  - 277-82
LID - 10.1176/appi.psy.51.4.277 [doi]
AB  - BACKGROUND: The authors review the literature related to patients who obtain a
      Do-Not-Resuscitate (DNR) order in preparation for a suicide attempt. OBJECTIVE:
      The authors review the ethical issues involved in making a decision to
      resuscitate or not in an attempted suicide with a DNR order. METHOD: The authors 
      address the potential legal consequences of action or inaction and clinical
      issues to consider before a DNR order is issued. RESULTS: DNR laws do not take
      into account the situation of the mentally ill person framing a DNR order as a
      preparation for suicide. CONCLUSION: The article recommends screening for
      suicidal ideation before issuing DNR orders, having clear hospital policies
      regarding the honoring of DNR orders if suicide is attempted, and clarification
      of state DNR laws regarding suicide.
FAU - Cook, Renee
AU  - Cook R
AD  - Southern Illinois University School of Medicine, Dept. of Psychiatry, P.O. Box
      19642, Springfield, IL 62794-9642, USA.
FAU - Pan, Philip
AU  - Pan P
FAU - Silverman, Ross
AU  - Silverman R
FAU - Soltys, Stephen M
AU  - Soltys SM
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Psychosomatics
JT  - Psychosomatics
JID - 0376506
SB  - IM
CIN - Psychosomatics. 2011 Sep-Oct;52(5):498. PMID: 21907080
MH  - Humans
MH  - *Mental Disorders
MH  - Resuscitation Orders/*ethics/*legislation & jurisprudence
MH  - Suicide/*ethics/*legislation & jurisprudence
MH  - United States
EDAT- 2010/07/01 06:00
MHDA- 2010/10/26 06:00
CRDT- 2010/07/01 06:00
PHST- 2010/07/01 06:00 [entrez]
PHST- 2010/07/01 06:00 [pubmed]
PHST- 2010/10/26 06:00 [medline]
AID - 51/4/277 [pii]
AID - 10.1176/appi.psy.51.4.277 [doi]
PST - ppublish
SO  - Psychosomatics. 2010 Jul-Aug;51(4):277-82. doi: 10.1176/appi.psy.51.4.277.


PMID- 20587644
OWN - NLM
STAT- MEDLINE
DCOM- 20100924
LR  - 20100726
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 256
IP  - 2
DP  - 2010 Aug
TI  - Localized development of knee osteoarthritis can be predicted from MR imaging
      findings a decade earlier.
PG  - 536-46
LID - 10.1148/radiol.10090683 [doi]
AB  - PURPOSE: To define localized development of knee osteoarthritis (OA) that arises 
      from anterior cruciate ligament (ACL) and meniscal injuries identified at
      magnetic resonance (MR) imaging performed a decade ago and the subsequent
      management of those findings in patients with subacute knee symptoms. MATERIALS
      AND METHODS: The present study was approved by local medical ethics review
      boards, and written informed consent was obtained. Three hundred twenty-six
      patients (mean age, 42 years; 108 female) from a previously reported series of
      855 patients were followed up with regard to the effect of MR imaging-guided
      treatment for subacute knee problems. The mean follow-up period was 10 years.
      Initial findings and treatment were compared with the follow-up radiograph and
      3.0-T MR image findings. Odds ratios (ORs), with corresponding 95% confidence
      intervals, were used to identify the effects between variables. RESULTS: Patients
      with ACL ruptures had an increased risk of developing joint space narrowing
      (JSN), cartilaginous defects, osteophytes, bone marrow lesions, and subchondral
      cysts medially or laterally (OR, 2.4-9.8). Patients with medial meniscal tears
      had an increased risk of developing JSN, cartilaginous defects, osteophytes, and 
      bone marrow lesions medially (OR, 2.0-15.3). Patients with lateral meniscal tears
      had an increased risk of developing JSN, cartilaginous defects, osteophytes, bone
      marrow lesions, and subchondral cysts laterally (OR, 2.1-10.5). Meniscectomy had 
      no effect on the risk of developing OA. CONCLUSION: Localized knee OA developed
      from risk factors identified from the findings of MR imaging performed a decade
      ago in patients with subacute knee symptoms and did not depend on the surgical
      treatment of those findings.
FAU - Huetink, Kasper
AU  - Huetink K
AD  - Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2300
      RC Leiden, The Netherlands. K.Huetink@lumc.nl
FAU - Nelissen, Rob G H H
AU  - Nelissen RG
FAU - Watt, Iain
AU  - Watt I
FAU - van Erkel, Arian R
AU  - van Erkel AR
FAU - Bloem, Johan L
AU  - Bloem JL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100629
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Magnetic Resonance Imaging/*methods
MH  - Osteoarthritis, Knee/*diagnosis
MH  - Prognosis
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
EDAT- 2010/07/01 06:00
MHDA- 2010/09/25 06:00
CRDT- 2010/07/01 06:00
PHST- 2010/07/01 06:00 [entrez]
PHST- 2010/07/01 06:00 [pubmed]
PHST- 2010/09/25 06:00 [medline]
AID - radiol.10090683 [pii]
AID - 10.1148/radiol.10090683 [doi]
PST - ppublish
SO  - Radiology. 2010 Aug;256(2):536-46. doi: 10.1148/radiol.10090683. Epub 2010 Jun
      29.


PMID- 20587155
OWN - NLM
STAT- MEDLINE
DCOM- 20110401
LR  - 20211020
IS  - 2769-6677 (Electronic)
IS  - 1559-6109 (Linking)
VI  - 49
IP  - 3
DP  - 2010 May
TI  - Transnational organizational considerations for sociocultural differences in
      ethics and virtual team functioning in laboratory animal science.
PG  - 270-3
AB  - Business models for transnational organizations include linking different
      geographies through common codes of conduct, policies, and virtual teams. Global 
      companies with laboratory animal science activities (whether outsourced or
      performed inhouse) often see the need for these business activities in relation
      to animal-based research and benefit from them. Global biomedical research
      organizations can learn how to better foster worldwide cooperation and teamwork
      by understanding and working with sociocultural differences in ethics and by
      knowing how to facilitate appropriate virtual team actions. Associated practices 
      include implementing codes and policies transcend cultural, ethnic, or other
      boundaries and equipping virtual teams with the needed technology, support, and
      rewards to ensure timely and productive work that ultimately promotes good
      science and patient safety in drug development.
FAU - Pritt, Stacy L
AU  - Pritt SL
AD  - Biological Test Center, Irvine, California, USA. stacy.pritt@bbraun.com
FAU - Mackta, Jayne
AU  - Mackta J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Assoc Lab Anim Sci
JT  - Journal of the American Association for Laboratory Animal Science : JAALAS
JID - 101269489
SB  - IM
MH  - Cooperative Behavior
MH  - *Cultural Diversity
MH  - Internationality
MH  - Laboratory Animal Science/*ethics
MH  - Organizations
MH  - Policy
PMC - PMC2877296
EDAT- 2010/07/01 06:00
MHDA- 2011/04/02 06:00
CRDT- 2010/07/01 06:00
PHST- 2010/07/01 06:00 [entrez]
PHST- 2010/07/01 06:00 [pubmed]
PHST- 2011/04/02 06:00 [medline]
PST - ppublish
SO  - J Am Assoc Lab Anim Sci. 2010 May;49(3):270-3.


PMID- 20587097
OWN - NLM
STAT- MEDLINE
DCOM- 20100813
LR  - 20100630
IS  - 0020-1324 (Print)
IS  - 0020-1324 (Linking)
VI  - 55
IP  - 7
DP  - 2010 Jul
TI  - An intervention to improve respiratory therapists' comfort with end-of-life care.
PG  - 858-65
AB  - BACKGROUND: Respiratory therapists (RTs) are often involved in treating seriously
      ill and dying patients, but receive little instruction in end-of-life care.
      Prompted by several difficult cases, we developed an interdisciplinary program to
      introduce practicing RTs to ethical and end-of-life issues, and evaluated the
      program with a dedicated survey instrument. METHODS: A convenience sample of RTs 
      from a university hospital and nearby community hospitals participated in a
      one-day interactive program, in 2005 (n = 49) and in 2008 (n = 36), that included
      role-play and didactic components. The questionnaire completed before and after
      the program included scales on comfort with end-of-life care and role in
      end-of-life care, and knowledge indices. RESULTS: Nearly all the RTs had recently
      encountered end-of-life situations, yet most had not received dedicated training 
      and felt ill-prepared to deal with these situations; one third reported distress 
      related to withdrawal of treatment. The 78 participants who completed both the
      before and after surveys had increased comfort with end-of-life care (P < .001)
      and their perception of their role in end-of-life care (P < .001). Knowledge
      about end-of-life care also increased (P < .001). CONCLUSIONS: A one-day
      interactive educational intervention can improve short-term RT comfort and role
      perception concerning end-of-life care. Evaluation of longer-term clinical
      outcomes and implementation in other venues is needed.
FAU - Brown-Saltzman, Katherine
AU  - Brown-Saltzman K
AD  - UCLA Healthcare System Ethics Center, Los Angeles CA 90095, USA.
FAU - Upadhya, Devesh
AU  - Upadhya D
FAU - Larner, Lyle
AU  - Larner L
FAU - Wenger, Neil S
AU  - Wenger NS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Respir Care
JT  - Respiratory care
JID - 7510357
SB  - IM
CIN - Respir Care. 2010 Jul;55(7):949. PMID: 20587111
MH  - Adult
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - *Inservice Training
MH  - Male
MH  - *Quality of Health Care
MH  - Respiratory Therapy/education/ethics/*standards
MH  - Terminal Care/ethics/*standards
EDAT- 2010/07/01 06:00
MHDA- 2010/08/14 06:00
CRDT- 2010/07/01 06:00
PHST- 2010/07/01 06:00 [entrez]
PHST- 2010/07/01 06:00 [pubmed]
PHST- 2010/08/14 06:00 [medline]
PST - ppublish
SO  - Respir Care. 2010 Jul;55(7):858-65.


PMID- 20587040
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1550-2783 (Electronic)
IS  - 1550-2783 (Linking)
VI  - 7
DP  - 2010 Jun 29
TI  - Potentially fatal new trend in performance enhancement: a cautionary note on
      nitrite.
PG  - 25
LID - 10.1186/1550-2783-7-25 [doi]
AB  - BACKGROUND: Considerable interest has been shown by athletes and scientists in
      the potential for nitric oxide and associated vasodilators to enhance
      performance. This study aims to explore potential misuse of vasodilators by the
      athletes, and to highlight the growing concern over these agents. METHODS:
      Retrospective analyses of anonymous inquiries recorded in the Drug Information
      Database (DID) between January 2006 and June 2008 (inclusive). In this 30-month
      period, the DID recorded 198,023 inquiries, of which 118,724 were UK Licensed
      Pharmaceutical products with a further 79,299 inquiries made for substance not
      found in the database. RESULTS: Phosphodiesterase type 5 (PDE-5) inhibitors,
      dominated by Viagra(R), ranked 16th among the substance groups. The proportion of
      the inquiries made regarding PDE-5 inhibitors, especially in comparison to
      antibiotics, painkillers or alcohol, appears to be above the level that would
      normally be expected from medical need. No significant change in the months
      leading up to the Beijing Olympics was observed. On the contrary, the
      Nitric/Nitrate group showed a notable increase between 2006-2007 and 2008,
      suggesting a potential increase in interest in using nitric oxide among athletes.
      CONCLUSIONS: With patents recently filed for the use of agents containing sodium 
      nitrite/nitrate to enhance blood flow for performance enhancement in sport,
      coupled with anecdotal evidence from internet athlete forums and media, there is 
      a concern that athletes may endanger their health by using vasodilators to
      enhance athletic performance. PDE-5 inhibitors or chemicals in the
      nitrate/nitrate group are currently not prohibited or tested for by the doping
      control agencies but some are highly dangerous to health and can lead to
      cardiovascular collapse, coma and death. Its promotion among athletes as a
      performance enhancing supplement is ethically and medically questionable.
FAU - Petroczi, Andrea
AU  - Petroczi A
AD  - School of Life Sciences, Kingston University, Penrhyn Road, Kingston upon Thames,
      London KT1 2EE, UK. D.Naughton@kingston.ac.uk.
FAU - Naughton, Declan P
AU  - Naughton DP
LA  - eng
PT  - Journal Article
DEP - 20100629
PL  - United States
TA  - J Int Soc Sports Nutr
JT  - Journal of the International Society of Sports Nutrition
JID - 101234168
PMC - PMC2909922
EDAT- 2010/07/01 06:00
MHDA- 2010/07/01 06:01
CRDT- 2010/07/01 06:00
PHST- 2010/03/23 00:00 [received]
PHST- 2010/06/29 00:00 [accepted]
PHST- 2010/07/01 06:00 [entrez]
PHST- 2010/07/01 06:00 [pubmed]
PHST- 2010/07/01 06:01 [medline]
AID - 1550-2783-7-25 [pii]
AID - 10.1186/1550-2783-7-25 [doi]
PST - epublish
SO  - J Int Soc Sports Nutr. 2010 Jun 29;7:25. doi: 10.1186/1550-2783-7-25.


PMID- 20587008
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20211020
IS  - 1466-609X (Electronic)
IS  - 1364-8535 (Linking)
VI  - 14
IP  - 3
DP  - 2010
TI  - Ethics roundtable: 'Open-ended ICU care: can we afford it?'.
PG  - 222
LID - 10.1186/cc8962 [doi]
AB  - THE CASE: The patient is a 27-year-old previously healthy male with a diagnosis
      of viral encephalitis with a lymphocytic pleocytosis on cerebrospinal fluid
      examination. For 3 months, he has been in status epilepticus (SE) on high doses
      of barbiturates, benzodiazepines, and ketamine and a ketogenic feeding-tube
      formula. He remains in burst suppression on continuous electroencephalography
      (EEG). He is trached and has a percutaneous endoscopic gastrostomy (PEG) feeding 
      tube. He has been treated several times for pneumonia, and he is on a warming
      blanket and is on vasopressors to maintain his blood pressure. His vitals are
      stable and his lab work is within limits. The sedation is decreased under EEG
      guidance every 72 hours, after which he goes back into SE and heavy sedation is
      resumed. The latest magnetic resonance imaging (MRI) shows edema but otherwise no
      obvious permanent cortical damage. The family wants a realistic assessment of the
      likely outcome. The neurologist tells them the literature suggests the outlook is
      poor but not 100% fatal. As long as all of his other organs are functioning on
      life support, there is always a chance the seizures will stop at some time in the
      future, and so the neurologist recommends an open-ended intensive care unit (ICU)
      plan and hopes for that outcome.
FAU - Crippen, David
AU  - Crippen D
AD  - Department of Critical Care Medicine, University of Pittsburgh Medical Center,
      644a Saife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA. crippen@pitt.edu
FAU - Burrows, Dick
AU  - Burrows D
FAU - Stocchetti, Nino
AU  - Stocchetti N
FAU - Mayer, Stephan A
AU  - Mayer SA
FAU - Andrews, Peter
AU  - Andrews P
FAU - Bleck, Tom
AU  - Bleck T
FAU - Whetstine, Leslie
AU  - Whetstine L
LA  - eng
PT  - Case Reports
PT  - Clinical Conference
PT  - Journal Article
DEP - 20100621
PL  - England
TA  - Crit Care
JT  - Critical care (London, England)
JID - 9801902
SB  - IM
CIN - Crit Care. 2010;14(5):447; author reply 447. PMID: 21067527
MH  - Adult
MH  - Encephalitis, Viral/complications/physiopathology
MH  - *Hospital Costs
MH  - Humans
MH  - Intensive Care Units/*economics
MH  - Long-Term Care/economics
MH  - Male
MH  - Prognosis
MH  - Resource Allocation/*ethics
MH  - Status Epilepticus/drug therapy/etiology
PMC - PMC2911684
EDAT- 2010/07/01 06:00
MHDA- 2011/01/07 06:00
CRDT- 2010/07/01 06:00
PHST- 2010/07/01 06:00 [entrez]
PHST- 2010/07/01 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
AID - cc8962 [pii]
AID - 10.1186/cc8962 [doi]
PST - ppublish
SO  - Crit Care. 2010;14(3):222. doi: 10.1186/cc8962. Epub 2010 Jun 21.


PMID- 20586763
OWN - NLM
STAT- MEDLINE
DCOM- 20110120
LR  - 20220311
IS  - 1530-0277 (Electronic)
IS  - 0145-6008 (Linking)
VI  - 34
IP  - 9
DP  - 2010 Sep 1
TI  - Laboratory models available to study alcohol-induced organ damage and immune
      variations: choosing the appropriate model.
PG  - 1489-511
LID - 10.1111/j.1530-0277.2010.01234.x [doi]
AB  - The morbidity and mortality resulting from alcohol-related diseases globally
      impose a substantive cost to society. To minimize the financial burden on society
      and improve the quality of life for individuals suffering from the ill effects of
      alcohol abuse, substantial research in the alcohol field is focused on
      understanding the mechanisms by which alcohol-related diseases develop and
      progress. Since ethical concerns and inherent difficulties limit the amount of
      alcohol abuse research that can be performed in humans, most studies are
      performed in laboratory animals. This article summarizes the various laboratory
      models of alcohol abuse that are currently available and are used to study the
      mechanisms by which alcohol abuse induces organ damage and immune defects. The
      strengths and weaknesses of each of the models are discussed. Integrated into the
      review are the presentations that were made in the symposium "Methods of Ethanol 
      Application in Alcohol Model-How Long is Long Enough" at the joint 2008 Research 
      Society on Alcoholism (RSA) and International Society for Biomedical Research on 
      Alcoholism (ISBRA) meeting, Washington, DC, emphasizing the importance not only
      of selecting the most appropriate laboratory alcohol model to address the
      specific goals of a project but also of ensuring that the findings can be
      extrapolated to alcohol-induced diseases in humans.
FAU - D'Souza El-Guindy, Nympha B
AU  - D'Souza El-Guindy NB
AD  - Department of Internal Medicine, Division of Digestive Diseases, University of
      Kentucky and Veterans Affairs Medical Center, Lexington, Kentucky, USA.
      nbdsou0@uky.edu
FAU - Kovacs, Elizabeth J
AU  - Kovacs EJ
FAU - De Witte, Philippe
AU  - De Witte P
FAU - Spies, Claudia
AU  - Spies C
FAU - Littleton, John M
AU  - Littleton JM
FAU - de Villiers, Willem J S
AU  - de Villiers WJ
FAU - Lott, Amanda J
AU  - Lott AJ
FAU - Plackett, Timothy P
AU  - Plackett TP
FAU - Lanzke, Nadine
AU  - Lanzke N
FAU - Meadows, Gary G
AU  - Meadows GG
LA  - eng
GR  - R01 AA013168/AA/NIAAA NIH HHS/United States
GR  - R01 AA013168-04/AA/NIAAA NIH HHS/United States
GR  - R01 AA012034/AA/NIAAA NIH HHS/United States
GR  - R01 AA007293/AA/NIAAA NIH HHS/United States
GR  - K05 AA017149/AA/NIAAA NIH HHS/United States
GR  - R01 AA07293/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100625
PL  - England
TA  - Alcohol Clin Exp Res
JT  - Alcoholism, clinical and experimental research
JID - 7707242
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Alcoholic Intoxication/immunology
MH  - Alcoholism/*immunology/*pathology
MH  - Animals
MH  - *Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Drug Administration Routes
MH  - Drug Administration Schedule
MH  - Ethanol/administration & dosage/*pharmacology
MH  - Humans
MH  - Immunity/*drug effects
PMC - PMC2929290
MID - NIHMS202062
EDAT- 2010/07/01 06:00
MHDA- 2011/01/21 06:00
CRDT- 2010/07/01 06:00
PHST- 2010/07/01 06:00 [entrez]
PHST- 2010/07/01 06:00 [pubmed]
PHST- 2011/01/21 06:00 [medline]
AID - ACER1234 [pii]
AID - 10.1111/j.1530-0277.2010.01234.x [doi]
PST - ppublish
SO  - Alcohol Clin Exp Res. 2010 Sep 1;34(9):1489-511. doi:
      10.1111/j.1530-0277.2010.01234.x. Epub 2010 Jun 25.


PMID- 20571424
OWN - NLM
STAT- MEDLINE
DCOM- 20100709
LR  - 20200930
IS  - 1944-7884 (Electronic)
IS  - 1525-4135 (Linking)
VI  - 54 Suppl 1
DP  - 2010 Jul
TI  - A case study: lessons learned from human papillomavirus vaccine development:
      approval of a vaccine for use in children and young adolescents for prevention of
      an adult disease.
PG  - S50-2
LID - 10.1097/QAI.0b013e3181e2d54d [doi]
AB  - This article presents the adolescent clinical trials program for the quadrivalent
      HPV vaccine (Merck and Co, Inc, Whitehouse Station, NJ) as a case study of the
      development of a preventive intervention for use in young adolescents to protect 
      against a future sexually transmitted infection and its associated diseases. In
      light of similarities in Human Papillomavirus (HPV) and HIV with regard to sexual
      transmission and the associated social and ethical issues related to prevention
      trial development, lessons learned from the approach taken to the inclusion of
      adolescents in the quadrivalent HPV vaccine program have potential relevance to
      future HIV prevention trials. Epidemiologic support for HPV vaccination in
      adolescents and a regulatory-approved approach to immunogenicity studies for
      bridging of efficacy from adults formed the basis for including young adolescents
      in the HPV program. The successful achievement of regulatory approval for use of 
      this prophylactic intervention in young adolescents for prevention of a sexually 
      transmitted infection that is most frequently not acquired before mid to late
      adolescence required understanding of the particular challenges of studying the
      vulnerable adolescent population with respect to issues such as federal
      regulations, the role of parents, confidentiality, empowerment, and retention,
      and awareness of the social and political context within which prevention
      interventions are introduced.
FAU - Garner, Elizabeth I O
AU  - Garner EI
AD  - Vaccines Clinical Research, Merck, Inc, North Wales, PA 19454, USA.
      elizabeth_garner@merck.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Acquir Immune Defic Syndr
JT  - Journal of acquired immune deficiency syndromes (1999)
JID - 100892005
RN  - 0 (Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18)
RN  - 0 (Papillomavirus Vaccines)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Child
MH  - *Drug Approval
MH  - Female
MH  - Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18
MH  - Humans
MH  - Male
MH  - Papillomavirus Infections/prevention & control
MH  - Papillomavirus Vaccines/*therapeutic use
MH  - Parental Consent
MH  - Patient Selection
MH  - United States
MH  - Young Adult
EDAT- 2010/07/01 06:00
MHDA- 2010/07/10 06:00
CRDT- 2010/06/24 06:00
PHST- 2010/06/24 06:00 [entrez]
PHST- 2010/07/01 06:00 [pubmed]
PHST- 2010/07/10 06:00 [medline]
AID - 10.1097/QAI.0b013e3181e2d54d [doi]
AID - 00126334-201007011-00009 [pii]
PST - ppublish
SO  - J Acquir Immune Defic Syndr. 2010 Jul;54 Suppl 1:S50-2. doi:
      10.1097/QAI.0b013e3181e2d54d.


PMID- 20571422
OWN - NLM
STAT- MEDLINE
DCOM- 20100709
LR  - 20200930
IS  - 1944-7884 (Electronic)
IS  - 1525-4135 (Linking)
VI  - 54 Suppl 1
DP  - 2010 Jul
TI  - Involving vulnerable populations of youth in HIV prevention clinical research.
PG  - S43-9
LID - 10.1097/QAI.0b013e3181e3627d [doi]
AB  - Adolescents continue to be at high risk for HIV infection, with young men who
      have sex with men and youth with drug abuse and/or mental health problems at
      particularly high risk. Multiple factors may interact to confer risk for these
      youth. Engaging vulnerable youth in HIV prevention research can present unique
      challenges in the areas of enrollment, retention, and trial adherence. Examples
      of successful engagement with vulnerable youth offer encouraging evidence for the
      feasibility of including these youth in clinical trials. Ethical challenges must 
      be taken into consideration before embarking on biomedical HIV prevention studies
      with vulnerable youth, especially in the global context. Given the many
      individual and contextual factors that contribute to their high-risk status, it
      is essential that vulnerable youth populations be included in HIV prevention
      clinical research studies.
FAU - Borek, Nicolette
AU  - Borek N
AD  - National Institutes of Health, National Institute on Drug Abuse, Division of
      Clinical Neuroscience and Behavioral Research, Bethesda, MD 20892, USA.
      nborek@nida.nih.gov
FAU - Allison, Susannah
AU  - Allison S
FAU - Caceres, Carlos F
AU  - Caceres CF
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Acquir Immune Defic Syndr
JT  - Journal of acquired immune deficiency syndromes (1999)
JID - 100892005
SB  - IM
MH  - Adolescent
MH  - *Biomedical Research/ethics
MH  - Clinical Trials as Topic/ethics
MH  - Drug Users/psychology
MH  - Female
MH  - HIV Infections/*prevention & control
MH  - Homosexuality, Male
MH  - Humans
MH  - Male
MH  - Mental Disorders/psychology
MH  - Minority Groups
MH  - Risk Factors
MH  - Transsexualism
MH  - *Vulnerable Populations
EDAT- 2010/07/01 06:00
MHDA- 2010/07/10 06:00
CRDT- 2010/06/24 06:00
PHST- 2010/06/24 06:00 [entrez]
PHST- 2010/07/01 06:00 [pubmed]
PHST- 2010/07/10 06:00 [medline]
AID - 10.1097/QAI.0b013e3181e3627d [doi]
AID - 00126334-201007011-00008 [pii]
PST - ppublish
SO  - J Acquir Immune Defic Syndr. 2010 Jul;54 Suppl 1:S43-9. doi:
      10.1097/QAI.0b013e3181e3627d.


PMID- 20571420
OWN - NLM
STAT- MEDLINE
DCOM- 20100709
LR  - 20200930
IS  - 1944-7884 (Electronic)
IS  - 1525-4135 (Linking)
VI  - 54 Suppl 1
DP  - 2010 Jul
TI  - Behavioral considerations for engaging youth in HIV clinical research.
PG  - S25-30
LID - 10.1097/QAI.0b013e3181e15c22 [doi]
AB  - From both scientific and ethical perspectives, it is important that youth be
      enrolled in biomedical HIV prevention clinical trials. At the same time,
      adolescents, as minors, are considered a vulnerable population requiring
      particular attention to the reduction of potential harm associated with
      participation in such trials. In this article, we review the evidence supporting 
      enrollment of youth in HIV clinical trials, including data on HIV infection
      rates, sexual behavior, and cognitive, psychosocial, and neurophysiological
      development. Next, we address the potential risks associated with clinical trial 
      participation, with a focus on the concept of preventive misconception, the
      tendencies to (1) overestimate the probability of assignment to the experimental 
      condition, as opposed to the placebo, and (2) assume that the experimental
      intervention is efficacious. Finally, we discuss targeted interventions to reduce
      preventive misconception and the importance of developing and testing
      adolescent-friendly risk-reduction interventions that are tailored to the
      structure and time frame of a biomedical HIV prevention clinical trial. The very 
      issues that make inclusion of youth in HIV prevention clinical trials necessary
      also demand that particularly intensive efforts be made to protect participating 
      minors from the harm that could accrue from a clinical trial.
FAU - Hosek, Sybil G
AU  - Hosek SG
AD  - Department of Psychiatry-Child and Adolescent Division, John Stroger Hospital of 
      Cook County, Chicago, IL 60612, USA. sybilhosek@earthlink.net
FAU - Zimet, Gregory D
AU  - Zimet GD
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Acquir Immune Defic Syndr
JT  - Journal of acquired immune deficiency syndromes (1999)
JID - 100892005
SB  - IM
MH  - Adolescent
MH  - *Adolescent Behavior/psychology
MH  - Adolescent Development
MH  - *Biomedical Research
MH  - Clinical Trials as Topic
MH  - HIV Infections/*prevention & control/psychology
MH  - Humans
MH  - Informed Consent
MH  - Risk Factors
MH  - Risk-Taking
MH  - Young Adult
EDAT- 2010/07/01 06:00
MHDA- 2010/07/10 06:00
CRDT- 2010/06/24 06:00
PHST- 2010/06/24 06:00 [entrez]
PHST- 2010/07/01 06:00 [pubmed]
PHST- 2010/07/10 06:00 [medline]
AID - 10.1097/QAI.0b013e3181e15c22 [doi]
AID - 00126334-201007011-00006 [pii]
PST - ppublish
SO  - J Acquir Immune Defic Syndr. 2010 Jul;54 Suppl 1:S25-30. doi:
      10.1097/QAI.0b013e3181e15c22.


PMID- 20571419
OWN - NLM
STAT- MEDLINE
DCOM- 20100709
LR  - 20200930
IS  - 1944-7884 (Electronic)
IS  - 1525-4135 (Linking)
VI  - 54 Suppl 1
DP  - 2010 Jul
TI  - Ethical and regulatory considerations for the inclusion of adolescents in HIV
      biomedical prevention research.
PG  - S18-24
LID - 10.1097/QAI.0b013e3181e2012e [doi]
AB  - Adolescents should be enrolled in ethically appropriate and scientifically
      rigorous HIV biomedical prevention research involving vaccines, pre-exposure
      prophylaxis, or microbicides. There is general agreement that children should
      only be enrolled in a clinical trial if the scientific objectives cannot be met
      either through enrolling adult subjects who can provide informed consent
      personally or through conducting research using animal models. In addition, the
      risks to which children are exposed in a clinical trial without the possibility
      of direct therapeutic benefit must be low. Children also should not be placed at 
      a disadvantage after being enrolled in a clinical trial by, for example, being
      exposed to an unnecessarily risky intervention or by failing to receive a
      comparable treatment that would prevent significant morbidity or mortality. In
      light of this shared framework, we discuss the timing of enrolling adolescents in
      HIV prevention trials; some general study design considerations that may be
      necessary for adequate labeling of products for an adolescent indication; the use
      of data obtained from international studies for licensure applications in the
      United States; the role of parental permission and adolescent assent to research 
      participation; and the inclusion of pregnant adolescents in HIV biomedical
      prevention research.
FAU - Nelson, Robert M
AU  - Nelson RM
AD  - Office of Pediatric Therapeutics, Office of the Commissioner, Food and Drug
      Administration, Silver Spring, MD 20993, USA. robert.nelson@fda.hhs.gov
FAU - Lewis, Linda L
AU  - Lewis LL
FAU - Struble, Kimberly
AU  - Struble K
FAU - Wood, Susan F
AU  - Wood SF
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Acquir Immune Defic Syndr
JT  - Journal of acquired immune deficiency syndromes (1999)
JID - 100892005
RN  - 0 (Anti-Infective Agents, Local)
RN  - 0 (Placebos)
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Anti-Infective Agents, Local
MH  - Biomedical Research/*ethics/legislation & jurisprudence
MH  - Clinical Trials as Topic/ethics/legislation & jurisprudence
MH  - Female
MH  - HIV Infections/*prevention & control
MH  - Humans
MH  - Informed Consent/ethics/legislation & jurisprudence
MH  - Male
MH  - Placebos
MH  - Pregnancy
MH  - Risk Factors
MH  - United States
EDAT- 2010/07/01 06:00
MHDA- 2010/07/10 06:00
CRDT- 2010/06/24 06:00
PHST- 2010/06/24 06:00 [entrez]
PHST- 2010/07/01 06:00 [pubmed]
PHST- 2010/07/10 06:00 [medline]
AID - 10.1097/QAI.0b013e3181e2012e [doi]
AID - 00126334-201007011-00005 [pii]
PST - ppublish
SO  - J Acquir Immune Defic Syndr. 2010 Jul;54 Suppl 1:S18-24. doi:
      10.1097/QAI.0b013e3181e2012e.


PMID- 20571417
OWN - NLM
STAT- MEDLINE
DCOM- 20100709
LR  - 20200930
IS  - 1944-7884 (Electronic)
IS  - 1525-4135 (Linking)
VI  - 54 Suppl 1
DP  - 2010 Jul
TI  - Introduction: Paving the way for biomedical HIV prevention interventions in
      youth.
PG  - S1-4
LID - 10.1097/QAI.0b013e3181e2cf8f [doi]
AB  - The HIV epidemic among youth continues to grow at alarming proportions throughout
      the world. Efficacious and comprehensive biomedical prevention interventions are 
      desperately needed for this vulnerable population if a reduction in global HIV
      incidence is to be achieved. To succeed at enrolling youth in studies of such
      modalities, communities whose youth will be participating must be highly engaged 
      throughout the spectrum of research concept development to implementation and
      later translation into programs. In this process, there are numerous challenges, 
      both intrinsic and extrinsic to the youth themselves. Intrinsic ones include
      developmental considerations in physiology, pharmacology, and behavior; extrinsic
      considerations are those in the community, ethical, legal, and regulatory arenas 
      and those in designing clinical trials for youth to feasibly participate. We
      convened a consultative meeting to deliberate over these considerations among a
      variety of experts representing youth and their community, advocacy groups,
      academia, industry, regulators, and others in the federal government. Broad
      recommendations aimed at many stakeholders in the adolescent HIV prevention
      research agenda were made and were to improve the timely inclusion of youth in
      this research to ensure that prevention agents can be used safely by youth as
      soon as they become available to adults.
FAU - Kapogiannis, Bill G
AU  - Kapogiannis BG
AD  - Pediatric, Adolescent, and Maternal AIDS Branch, Center for Research for Mothers 
      and Children, Eunice Kennedy Shriver National Institute of Child Health and Human
      Development, National Institutes of Health, Bethesda, MD 20892-7510, USA.
      kapogiannisb@mail.nih.gov
FAU - Handelsman, Ed
AU  - Handelsman E
FAU - Ruiz, Monica S
AU  - Ruiz MS
FAU - Lee, Sonia
AU  - Lee S
LA  - eng
PT  - Introductory Journal Article
PL  - United States
TA  - J Acquir Immune Defic Syndr
JT  - Journal of acquired immune deficiency syndromes (1999)
JID - 100892005
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Biomedical Research
MH  - Clinical Trials as Topic
MH  - Female
MH  - HIV Infections/*prevention & control
MH  - Humans
MH  - Male
MH  - Risk Factors
MH  - Young Adult
EDAT- 2010/07/01 06:00
MHDA- 2010/07/10 06:00
CRDT- 2010/06/24 06:00
PHST- 2010/06/24 06:00 [entrez]
PHST- 2010/07/01 06:00 [pubmed]
PHST- 2010/07/10 06:00 [medline]
AID - 10.1097/QAI.0b013e3181e2cf8f [doi]
AID - 00126334-201007011-00001 [pii]
PST - ppublish
SO  - J Acquir Immune Defic Syndr. 2010 Jul;54 Suppl 1:S1-4. doi:
      10.1097/QAI.0b013e3181e2cf8f.


PMID- 20566553
OWN - NLM
STAT- MEDLINE
DCOM- 20100928
LR  - 20171116
IS  - 1941-2479 (Electronic)
IS  - 1010-5395 (Linking)
VI  - 22
IP  - 3 Suppl
DP  - 2010 Jul
TI  - New steps for tobacco control in and outside of China.
PG  - 189S-196S
LID - 10.1177/1010539510373012 [doi]
AB  - In China during the last decade, citizens have rarely agitated against the
      ubiquity of cigarettes, at the same time that tobacco products have been
      responsible for killing more than a million people a year and tobacco-control
      programs have been enjoying a marked growth in logistical support, discursive
      attention, and funding. In this article, the author argues that China's ongoing
      popular quiescence regarding tobacco stems in part from strategic miscalculations
      that public health advocates are making. Favoring conceptual logics of expertise,
      population management, health economics, disease etiology, and rational choice,
      tobacco control in China is leaving unproblematized the political economic
      sources of cigarettes, the social suffering tobacco generates, and the ethics,
      everyday practices, and desires binding citizens and cigarettes together into
      webs of sociality. Bringing anthropological research to bear, the article
      describes ways that these strategic miscalculations have unfolded and makes
      suggestions for alternative ways that public health advocates can help Chinese
      citizens achieve the collective purpose to repudiate tobacco.
FAU - Kohrman, Matthew
AU  - Kohrman M
AD  - Stanford University, Stanford, CA 94305-6055, USA. kohrman@stanford.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - China
TA  - Asia Pac J Public Health
JT  - Asia-Pacific journal of public health
JID - 8708538
SB  - IM
MH  - Attitude to Health
MH  - China/epidemiology
MH  - Female
MH  - Financing, Government
MH  - Humans
MH  - *International Cooperation
MH  - Interviews as Topic
MH  - Male
MH  - *Public Health Practice
MH  - Qualitative Research
MH  - Smoking/epidemiology/legislation & jurisprudence/psychology
MH  - *Smoking Prevention
MH  - *Social Control Policies
MH  - Tobacco Industry
EDAT- 2010/07/01 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/06/23 06:00
PHST- 2010/06/23 06:00 [entrez]
PHST- 2010/07/01 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - 22/3_suppl/189S [pii]
AID - 10.1177/1010539510373012 [doi]
PST - ppublish
SO  - Asia Pac J Public Health. 2010 Jul;22(3 Suppl):189S-196S. doi:
      10.1177/1010539510373012.


PMID- 29213681
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1980-5764 (Print)
IS  - 1980-5764 (Linking)
VI  - 4
IP  - 3
DP  - 2010 Jul-Sep
TI  - Severe dementia: A review about diagnoses, therapeutic management and ethical
      issues.
PG  - 158-164
LID - 10.1590/S1980-57642010DN40300003 [doi]
AB  - North American data show that in the year 2000 around 4.5 million people had a
      diagnosis of dementia and more than a half were at moderate or severe stages of
      the disease. There is inevitable cognitive and functional decline caused by all
      etiologies of irreversible dementia as well as many behavioral symptoms that
      compromise the quality of life of both patients and caregivers. Few published
      studies have investigated issues concerning severe dementia such as predictors of
      mortality and life expectancy, nutrition, end of life issues and palliative care 
      in terminal dementia, as well as best pharmacological and non-pharmacological
      treatments. Due to the complexity that characterizes advanced dementia, it is
      important that this discussion starts as early as possible allowing some
      decisions to be taken, preferably when the patients can still express their
      opinion.
FAU - Schafirovits-Morillo, Lilian
AU  - Schafirovits-Morillo L
AD  - Disciplina de Geriatria, Departamento de Clinica Medica do Hospital das Clinicas 
      da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo SP, Brazil.
FAU - Suemoto, Claudia Kimie
AU  - Suemoto CK
AD  - Disciplina de Geriatria, Departamento de Clinica Medica do Hospital das Clinicas 
      da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo SP, Brazil.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Brazil
TA  - Dement Neuropsychol
JT  - Dementia & neuropsychologia
JID - 101506587
PMC - PMC5619284
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - dementia
OT  - severe
COIS- Disclosure: The authors report no conflicts of interest.
EDAT- 2010/07/01 00:00
MHDA- 2010/07/01 00:01
CRDT- 2017/12/08 06:00
PHST- 2017/12/08 06:00 [entrez]
PHST- 2010/07/01 00:00 [pubmed]
PHST- 2010/07/01 00:01 [medline]
AID - 10.1590/S1980-57642010DN40300003 [doi]
PST - ppublish
SO  - Dement Neuropsychol. 2010 Jul-Sep;4(3):158-164. doi:
      10.1590/S1980-57642010DN40300003.


PMID- 26271498
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150815
LR  - 20180209
IS  - 1939-5078 (Print)
IS  - 1939-5078 (Linking)
VI  - 1
IP  - 4
DP  - 2010 Jul
TI  - Moral psychology (ethics).
PG  - 511-518
LID - 10.1002/wcs.60 [doi]
AB  - This article examines a selection of currently lively debates in the quickly
      evolving, interdisciplinary field of moral psychology. Topics discussed include
      the possibility of amoralism, the nature of rationality, the (ir)rationality of
      emotions and intuitions, the psychology of cooperation and of (rational)
      commitment, weakness of will, free will, and the assignment of moral
      responsibility. Copyright (c) 2010 John Wiley & Sons, Ltd. For further resources 
      related to this article, please visit the WIREs website.
CI  - Copyright (c) 2010 John Wiley & Sons, Ltd.
FAU - Andreou, Chrisoula
AU  - Andreou C
AD  - Department of Philosophy, University of Utah, Salt Lake City, UT 84112, USA.
LA  - eng
PT  - Journal Article
DEP - 20100311
PL  - United States
TA  - Wiley Interdiscip Rev Cogn Sci
JT  - Wiley interdisciplinary reviews. Cognitive science
JID - 101524169
EDAT- 2010/07/01 00:00
MHDA- 2010/07/01 00:01
CRDT- 2015/08/15 06:00
PHST- 2015/08/15 06:00 [entrez]
PHST- 2010/07/01 00:00 [pubmed]
PHST- 2010/07/01 00:01 [medline]
AID - 10.1002/wcs.60 [doi]
PST - ppublish
SO  - Wiley Interdiscip Rev Cogn Sci. 2010 Jul;1(4):511-518. doi: 10.1002/wcs.60. Epub 
      2010 Mar 11.


PMID- 25949612
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150507
LR  - 20201001
IS  - 1757-1472 (Print)
IS  - 1757-1472 (Linking)
VI  - 3
IP  - 1
DP  - 2010 Jul
TI  - Choosing for and with children: consent, assent and working with children in the 
      primary care setting.
PG  - 12-8
AB  - The complex ethical and legal concepts of consent, assent, capacity and best
      interests merit a fine-grained scrutiny in the context of providing health care
      for children. Empirical evidence points to children being much more competent
      than we are often prepared to admit and their views and concerns not always being
      given sufficient attention. Various models and guidelines help practitioners to
      redress this deficit and to assist in shared decision making between children and
      their parents. In addition, there is a case for adopting a more family centred
      perspective rather than an adversarial legalistic approach.
FAU - de Zulueta, Paquita
AU  - de Zulueta P
AD  - General Practitioner, Honorary Senior Clinical Lecturer, Imperial College,
      London, UK.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - London J Prim Care (Abingdon)
JT  - London journal of primary care
JID - 101576301
PMC - PMC3960699
OTO - NOTNLM
OT  - assent
OT  - best interests
OT  - capacity children
OT  - consent
EDAT- 2010/07/01 00:00
MHDA- 2010/07/01 00:01
CRDT- 2015/05/08 06:00
PHST- 2015/05/08 06:00 [entrez]
PHST- 2010/07/01 00:00 [pubmed]
PHST- 2010/07/01 00:01 [medline]
AID - 10.1080/17571472.2010.11493290 [doi]
PST - ppublish
SO  - London J Prim Care (Abingdon). 2010 Jul;3(1):12-8. doi:
      10.1080/17571472.2010.11493290.


PMID- 25163872
OWN - NLM
STAT- MEDLINE
DCOM- 20150515
LR  - 20140828
IS  - 1756-8765 (Electronic)
IS  - 1756-8757 (Linking)
VI  - 2
IP  - 3
DP  - 2010 Jul
TI  - A conceptual and computational model of moral decision making in human and
      artificial agents.
PG  - 454-85
LID - 10.1111/j.1756-8765.2010.01095.x [doi]
AB  - Recently, there has been a resurgence of interest in general, comprehensive
      models of human cognition. Such models aim to explain higher-order cognitive
      faculties, such as deliberation and planning. Given a computational
      representation, the validity of these models can be tested in computer
      simulations such as software agents or embodied robots. The push to implement
      computational models of this kind has created the field of artificial general
      intelligence (AGI). Moral decision making is arguably one of the most challenging
      tasks for computational approaches to higher-order cognition. The need for
      increasingly autonomous artificial agents to factor moral considerations into
      their choices and actions has given rise to another new field of inquiry
      variously known as Machine Morality, Machine Ethics, Roboethics, or Friendly AI. 
      In this study, we discuss how LIDA, an AGI model of human cognition, can be
      adapted to model both affective and rational features of moral decision making.
      Using the LIDA model, we will demonstrate how moral decisions can be made in many
      domains using the same mechanisms that enable general decision making.
      Comprehensive models of human cognition typically aim for compatibility with
      recent research in the cognitive and neural sciences. Global workspace theory,
      proposed by the neuropsychologist Bernard Baars (1988), is a highly regarded
      model of human cognition that is currently being computationally instantiated in 
      several software implementations. LIDA (Franklin, Baars, Ramamurthy, & Ventura,
      2005) is one such computational implementation. LIDA is both a set of
      computational tools and an underlying model of human cognition, which provides
      mechanisms that are capable of explaining how an agent's selection of its next
      action arises from bottom-up collection of sensory data and top-down processes
      for making sense of its current situation. We will describe how the LIDA model
      helps integrate emotions into the human decision-making process, and we will
      elucidate a process whereby an agent can work through an ethical problem to reach
      a solution that takes account of ethically relevant factors.
CI  - Copyright (c) 2010 Cognitive Science Society, Inc.
FAU - Wallach, Wendell
AU  - Wallach W
AD  - Interdisciplinary Center for Bioethics, Yale UniversityInstitute for Intelligent 
      Systems, The University of MemphisCognitive Science Program, Indiana University.
FAU - Franklin, Stan
AU  - Franklin S
FAU - Allen, Colin
AU  - Allen C
LA  - eng
PT  - Journal Article
DEP - 20100513
PL  - United States
TA  - Top Cogn Sci
JT  - Topics in cognitive science
JID - 101506764
SB  - IM
MH  - *Artificial Intelligence
MH  - Cognition/*ethics
MH  - Computer Simulation
MH  - Decision Making/*ethics
MH  - Humans
MH  - *Models, Psychological
MH  - *Morals
OTO - NOTNLM
OT  - Artificial general intelligence
OT  - Artificial intelligence
OT  - Global workspace theory
OT  - Machine ethics
OT  - Machine morality
OT  - Moral decision making
EDAT- 2010/07/01 00:00
MHDA- 2015/05/16 06:00
CRDT- 2014/08/29 06:00
PHST- 2014/08/29 06:00 [entrez]
PHST- 2010/07/01 00:00 [pubmed]
PHST- 2015/05/16 06:00 [medline]
AID - 10.1111/j.1756-8765.2010.01095.x [doi]
PST - ppublish
SO  - Top Cogn Sci. 2010 Jul;2(3):454-85. doi: 10.1111/j.1756-8765.2010.01095.x. Epub
      2010 May 13.


PMID- 25163871
OWN - NLM
STAT- MEDLINE
DCOM- 20150515
LR  - 20140828
IS  - 1756-8765 (Electronic)
IS  - 1756-8757 (Linking)
VI  - 2
IP  - 3
DP  - 2010 Jul
TI  - What does the modularity of morals have to do with ethics? Four moral sprouts
      plus or minus a few.
PG  - 430-53
LID - 10.1111/j.1756-8765.2009.01076.x [doi]
AB  - Flanagan (1991) was the first contemporary philosopher to suggest that a
      modularity of morals hypothesis (MMH) was worth consideration by cognitive
      science. There is now a serious empirically informed proposal that moral
      competence is best explained in terms of moral modules-evolutionarily ancient,
      fast-acting, automatic reactions to particular sociomoral experiences (Haidt &
      Joseph, 2007). MMH fleshes out an idea nascent in Aristotle, Mencius, and Darwin.
      We discuss the evidence for MMH, specifically an ancient version, "Mencian Moral 
      Modularity," which claims four innate modules, and "Social Intuitionist
      Modularity," which claims five innate modules. We compare these two moral
      modularity models, discuss whether the postulated modules are best conceived as
      perceptual/Fodorian or emotional/Darwinian, and consider whether assuming MMH
      true has any normative ethical consequences whatsoever. The discussion of MMH
      reconnects cognitive science with normative ethics in a way that involves the
      reassertion of the "is-ought" problem. We explain in a new way what this problem 
      is and why it would not yield. The reason does not involve the logic of "ought," 
      but rather the plasticity of human nature and the realistic options to "grow" and
      "do" human nature in multifarious legitimate ways.
CI  - Copyright (c) 2010 Cognitive Science Society, Inc.
FAU - Flanagan, Owen
AU  - Flanagan O
AD  - Department of Philosophy, Duke University.
FAU - Williams, Robert Anthony
AU  - Williams RA
LA  - eng
PT  - Journal Article
DEP - 20100121
PL  - United States
TA  - Top Cogn Sci
JT  - Topics in cognitive science
JID - 101506764
SB  - IM
MH  - Emotions/*ethics
MH  - *Ethical Theory
MH  - Humans
MH  - *Models, Psychological
MH  - *Morals
MH  - Perception/*ethics
OTO - NOTNLM
OT  - Emotions
OT  - Intuition
OT  - Is-ought
OT  - Mencius
OT  - Modularity
OT  - Modules
OT  - Moral
EDAT- 2010/07/01 00:00
MHDA- 2015/05/16 06:00
CRDT- 2014/08/29 06:00
PHST- 2014/08/29 06:00 [entrez]
PHST- 2010/07/01 00:00 [pubmed]
PHST- 2015/05/16 06:00 [medline]
AID - 10.1111/j.1756-8765.2009.01076.x [doi]
PST - ppublish
SO  - Top Cogn Sci. 2010 Jul;2(3):430-53. doi: 10.1111/j.1756-8765.2009.01076.x. Epub
      2010 Jan 21.


PMID- 23634478
OWN - NLM
STAT- MEDLINE
DCOM- 20130730
LR  - 20190513
IS  - 0026-4075 (Print)
IS  - 0026-4075 (Linking)
VI  - 175
IP  - 7 Suppl
DP  - 2010 Jul
TI  - U.S. Military HIV Research Program: successfully integrating HIV vaccine research
      with prevention, care, and treatment.
PG  - 42-4
AB  - In 1986, Congress mandated the U.S. Military HIV Research Program (MHRP) to
      protect service personnel and serve the global community by reducing the risk of 
      HIV-1 infection. More than 20 years later, MHRP has become a leader in
      international HIV vaccine development efforts, with five research sites in Africa
      and Asia. The program's growth has been achieved through the combination of
      strong HIV vaccine science, the careful development of international research
      sites, and partnerships with key research institutions in the host countries and 
      within the United States. In addition, the integration of prevention, care, and
      treatment services has helped MHRP build strong and trusting relationships with
      the communities in which research is conducted, while providing an ethical
      framework for the conduct of HIV clinical research.
FAU - Reilly, Lisa
AU  - Reilly L
AD  - U.S. Military HIV Research Program, Henry M. Jackson Foundation for the
      Advancement of Military Medicine, 1401 Rockville Pike, Suite 600, Rockville, MD
      20852, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - Mil Med
JT  - Military medicine
JID - 2984771R
RN  - 0 (AIDS Vaccines)
SB  - IM
MH  - *AIDS Vaccines
MH  - Africa
MH  - Biomedical Research
MH  - HIV Infections/prevention & control/*therapy
MH  - Humans
MH  - International Cooperation
MH  - *Military Personnel
MH  - Thailand
MH  - United States
EDAT- 2010/07/01 00:00
MHDA- 2013/07/31 06:00
CRDT- 2013/05/03 06:00
PHST- 2013/05/03 06:00 [entrez]
PHST- 2010/07/01 00:00 [pubmed]
PHST- 2013/07/31 06:00 [medline]
AID - 10.7205/milmed-d-10-00168 [doi]
PST - ppublish
SO  - Mil Med. 2010 Jul;175(7 Suppl):42-4. doi: 10.7205/milmed-d-10-00168.


PMID- 22610741
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20191112
IS  - 1812-2078 (Electronic)
IS  - 1812-2027 (Linking)
VI  - 8
IP  - 31
DP  - 2010 Jul-Sep
TI  - Revitalizing primary health care--another utopian goal?
PG  - 341-4
AB  - The quest for greater efficiency, fairness and responsiveness to the expectation 
      of the people that system serve have brought about three generations of health
      system reforms in the twentieth century. The first generation saw the founding of
      national health care systems and extension to middle income nations of social
      insurance systems in the 1940s and 1950s. By the late 1960s the rising costs of
      hospital based care, its usage by better off, inaccessibility by the poor and
      rural population of even the most basic services heralded second generation
      reforms promoting primary health care as a means of achieving the affordable
      universal coverage. It included the best public health strategy that is
      prevention and the highest ethical principle of public health that is equity. It 
      was expected the best system for reaching households with essential and
      affordable care, and the best route towards universal coverage. The primary
      health care approach though adopted universally did not materialize its notion of
      translating ethos of Health for All by 2000. Overall, primary health care
      movement by the end of 20th century became lifeless. Since the Declaration of
      Alma-Ata, fundamental changes have occurred affecting health service delivery,
      such as economic development and financing approaches, globalization of trade and
      knowledge, and the shift to privatization. This is the time to develop a new
      vision, taking into consideration the many changes affecting global health and
      the strategic developments in health of recent years. With this recognition, the 
      third generation of reforms now underway in many countries is driven by the idea 
      of responding more to demand, assuring access for the poor and emphasizing
      financing rather than just provision within the public sector. The key concern
      is: how to translate ethos of revitalizing in the reality. Otherwise the
      revitalizing concept will turn into utopian goal so like HFA by 2000 strategy.
FAU - Marahatta, Sujan B
AU  - Marahatta SB
AD  - Department of Community Medicine, Kathmandu University School of Medical
      Sciences, Dhulikhel, Kavre, Nepal.
LA  - eng
PT  - Journal Article
PL  - Nepal
TA  - Kathmandu Univ Med J (KUMJ)
JT  - Kathmandu University medical journal (KUMJ)
JID - 101215359
SB  - IM
MH  - Developing Countries
MH  - *Global Health
MH  - Health Care Reform/*organization & administration
MH  - Health Services Accessibility/*organization & administration
MH  - Humans
MH  - Leadership
MH  - Primary Health Care/*organization & administration
EDAT- 2010/07/01 00:00
MHDA- 2012/11/14 06:00
CRDT- 2012/05/22 06:00
PHST- 2012/05/22 06:00 [entrez]
PHST- 2010/07/01 00:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
AID - 10.3126/kumj.v8i3.6225 [doi]
PST - ppublish
SO  - Kathmandu Univ Med J (KUMJ). 2010 Jul-Sep;8(31):341-4. doi:
      10.3126/kumj.v8i3.6225.


PMID- 22577416
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2251-6638 (Electronic)
IS  - 1735-3955 (Linking)
VI  - 6
IP  - 2
DP  - 2010 Summer
TI  - Efficacy of Glucose-Insulin-Potassium Infusion on Left Ventricular Performance in
      Type II Diabetic Patients Undergoing Elective Coronary Artery Bypass Graft.Dy.
PG  - 62-8
AB  - BACKGROUND: Glucose-insulin-potassium (GIK) may improve cardiovascular
      performance after coronary artery bypass graft surgery (CABG). Our study
      investigated whether an infusion of GIK during elective CABG surgery in type II
      diabetic patient improved left ventricular performance. METHODS: We measured left
      ventricular ejection fraction and troponin (Tn), a myofibrillar structural
      protein. In this research, after ethics committee approval, 50 patients with type
      2 diabetes mellitus (DM) were enrolled into a randomized simple sampling,
      prospective, double-blind clinical trial study. In the case group, 500 cc
      dextrose water 5% plus 80 IU regular insulin and 40 mEq KCL were infused at the
      rate of 30 cc/hr. Patients in control group received 5% dextrose solution at the 
      rate of 30cc/hr. Venous blood samples were taken before induction of anesthesia, 
      after removal of the aortic clamp and before discharging from hospital. The
      Mann-Whitney-test was used to test for differences in troponin concentration
      between the groups. Fisher's exact test was used to determine whether there was a
      difference in the proportion of patients with a low ejection fraction (<45%) in
      the case group compared with that in the control group. Changes in potassium and 
      glucose concentrations over time within the groups were examined by ANOVA and
      paired t-tests. P < 0.05 was regarded as significant level for all tests.
      RESULTS: In this study, 50 patients with type 2 DM were evaluated in case and
      control groups. The mean age +/- SD in the case group was 57.7 +/- 9.9 years and 
      in the other group was 61.2 +/- 8.4 years. The groups were well-matched for age, 
      sex and number of bypass grafts. Randomization did not give an equal distribution
      of male and female patients. There wasn't any significant difference in ejection 
      fraction between the case and control groups before and after CABG (P > 0.05).
      Troponin concentration in the case group was 3.3 +/- 5.0 and in the control group
      was 3.9 +/- 5.1. There was no significant difference in Tn between the two groups
      before and after CABG (P > 0.05). There was not any significant difference in
      hospitalization time between the two groups. CONCLUSION: The results suggested
      that GIK can't improve left ventricular performance in routine CABG surgery.
FAU - Seied-Hosseini, Seied Mostafa
AU  - Seied-Hosseini SM
AD  - Resident of Cardiology, Department of Cardiology, School of Medicine, Isfahan
      University of Medical Sciences, Isfahan, Iran.
FAU - Pourmoghadas, Ali
AU  - Pourmoghadas A
FAU - Aghadavoudi, Omid
AU  - Aghadavoudi O
FAU - Amini, Masoud
AU  - Amini M
FAU - Mirmohammad-Sadeghi, Mohsen
AU  - Mirmohammad-Sadeghi M
FAU - Golabchi, Allahyar
AU  - Golabchi A
FAU - Hedayatpour, Behnood
AU  - Hedayatpour B
FAU - Haratian, Elham
AU  - Haratian E
FAU - Ghaem-Maghami, Narges
AU  - Ghaem-Maghami N
FAU - Khanoom Sharegh, Laleh
AU  - Khanoom Sharegh L
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - ARYA Atheroscler
JT  - ARYA atherosclerosis
JID - 101487337
PMC - PMC3347817
OTO - NOTNLM
OT  - Cardiac troponin
OT  - Cardiovascular surgery
OT  - Glucose-Insulin-Potassium
EDAT- 2010/07/01 00:00
MHDA- 2010/07/01 00:01
CRDT- 2012/05/12 06:00
PHST- 2009/03/15 00:00 [received]
PHST- 2010/04/22 00:00 [accepted]
PHST- 2012/05/12 06:00 [entrez]
PHST- 2010/07/01 00:00 [pubmed]
PHST- 2010/07/01 00:01 [medline]
PST - ppublish
SO  - ARYA Atheroscler. 2010 Summer;6(2):62-8.


PMID- 22453349
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120831
LR  - 20120328
IS  - 2151-8378 (Print)
IS  - 2151-8378 (Linking)
VI  - 16
IP  - 4
DP  - 2010 Jul
TI  - Outcomes of Retropubic Synthetic Midurethral Gynecare TVT Slings When Performed
      by Urogynecologists, Urologists, and General Gynecologists in a Private Community
      Hospital.
PG  - 238-41
LID - 10.1097/SPV.0b013e3181dffea9 [doi]
AB  - OBJECTIVES: : To compare perioperative outcomes of a retropubic synthetic
      midurethral Gynecare TVT slings (Gynecare Worldwide, division of Ethicon Inc, NJ)
      performed by urogynecologists, urologists, and general gynecologists. METHODS: : 
      This is a retrospective, cohort study of retropubic synthetic midurethral
      Gynecare TVT sling outcomes performed between 2001 and 2007 at a single
      institution. Other synthetic and nonsynthetic slings, or slings performed with
      concurrent surgeries were excluded. The primary outcomes were mean sling
      operating room (OR) time in minutes (min) and estimated blood loss in milliliters
      (mL). All variables were stratified by the surgeon's specialty: urogynecology
      (URO-GYN), urology (URO), and general gynecology (GYN). RESULTS: : Of 279
      Gynecare TVT sling procedures, 126 were performed by URO-GYN, 30 by URO, and 123 
      by GYN. Mean sling OR time was 38.8 +/- 8.5 minutes for URO-GYN, 42.6 +/- 11.2
      minutes for URO, and 39.8 +/- 14.3 minutes for GYN, P = 0.30. Estimated blood
      loss was 56.6 +/- 68.3 mL for URO-GYN, 69.7 +/- 82.6 mL for URO, and 68.8 +/-
      73.4 mL for GYN, P = 0.37. The intraoperative complications (bladder, urethral
      perforations, and hemorrhage) were similar among the specialties. In the
      postoperative period, there was no difference in subsequent need for urethrolysis
      (cutting or removal of the sling), return to OR, and readmission to the hospital 
      after the procedure among all 3 specialties. CONCLUSIONS: : All 3 specialties
      (urogynecologist, urologists, and general gynecologists) had similar major
      perioperative outcomes in performing retropubic synthetic midurethral Gynecare
      TVT slings.
FAU - Sanses, Tatiana V D
AU  - Sanses TV
AD  - Greater Baltimore Medical Center, Baltimore, MD; daggerDepartment of Obstetrics
      and Gynecology, University of Maryland Medical Center, Baltimore, MD.
FAU - Grimes, Cara L
AU  - Grimes CL
FAU - Hoskey, Kay A
AU  - Hoskey KA
FAU - Russo, Melissa L
AU  - Russo ML
FAU - Melick, Clifford F
AU  - Melick CF
FAU - Blomquist, Joan
AU  - Blomquist J
FAU - Ellerkmann, R Mark
AU  - Ellerkmann RM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Female Pelvic Med Reconstr Surg
JT  - Female pelvic medicine & reconstructive surgery
JID - 101528690
EDAT- 2010/07/01 00:00
MHDA- 2010/07/01 00:01
CRDT- 2012/03/29 06:00
PHST- 2012/03/29 06:00 [entrez]
PHST- 2010/07/01 00:00 [pubmed]
PHST- 2010/07/01 00:01 [medline]
AID - 10.1097/SPV.0b013e3181dffea9 [doi]
AID - 01436319-201008000-00010 [pii]
PST - ppublish
SO  - Female Pelvic Med Reconstr Surg. 2010 Jul;16(4):238-41. doi:
      10.1097/SPV.0b013e3181dffea9.


PMID- 22453347
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120831
LR  - 20120328
IS  - 2151-8378 (Print)
IS  - 2151-8378 (Linking)
VI  - 16
IP  - 4
DP  - 2010 Jul
TI  - Effect of suture selection on the rate of suture or mesh erosion and surgery
      failure in abdominal sacrocolpopexy.
PG  - 229-33
LID - 10.1097/SPV.0b013e3181d683a3 [doi]
AB  - OBJECTIVE: : To determine if suture type used for mesh attachment in abdominal
      sacrocolpopexy increases the rate of erosion/infection. METHODS: : Two groups
      were temporally divided from June 1996 to May 2001 where braided permanent
      sutures (2-0 Ethibond, Ethicon, Somerville, New Jersey) were exclusively used for
      graft placement (n = 161) and from August 2001 to May 2006 where exclusively
      monofilament delayed absorbable (2-0 PDS, Ethicon) was used (n = 254). Data were 
      analyzed for demographics, medical history, presenting/postoperative physical
      examination, concomitant surgeries, and complications. RESULTS: : Mesh/suture
      exposure rate was 3.7% (6/161) with Ethibond. There were no erosions with PDS (P 
      = 0.002). Colpopexy failure was 1.7% (2/116) with Ethibond and 0% (0/235) with
      PDS (P = 0.11). CONCLUSIONS: : Delayed absorbable, monofilament suture appears to
      reduce the risk of graft/suture erosion without increasing surgical failure.
FAU - Shepherd, Jonathan P
AU  - Shepherd JP
AD  - Department of Obstetrics and Gynecology, Magee Womens Hospital, University of
      Pittsburgh Medical Center, Pittsburgh, PA.
FAU - Higdon, Homer Lee 3rd
AU  - Higdon HL 3rd
FAU - Stanford, Edward J
AU  - Stanford EJ
FAU - Mattox, Thomas Fleming
AU  - Mattox TF
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Female Pelvic Med Reconstr Surg
JT  - Female pelvic medicine & reconstructive surgery
JID - 101528690
EDAT- 2010/07/01 00:00
MHDA- 2010/07/01 00:01
CRDT- 2012/03/29 06:00
PHST- 2012/03/29 06:00 [entrez]
PHST- 2010/07/01 00:00 [pubmed]
PHST- 2010/07/01 00:01 [medline]
AID - 10.1097/SPV.0b013e3181d683a3 [doi]
AID - 01436319-201008000-00008 [pii]
PST - ppublish
SO  - Female Pelvic Med Reconstr Surg. 2010 Jul;16(4):229-33. doi:
      10.1097/SPV.0b013e3181d683a3.


PMID- 22444621
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20120326
IS  - 1751-732X (Electronic)
IS  - 1751-7311 (Linking)
VI  - 4
IP  - 7
DP  - 2010 Jul
TI  - Sustainability of ruminant agriculture in the new context: feeding strategies and
      features of animal adaptability into the necessary holistic approach.
PG  - 1258-73
LID - 10.1017/S1751731110001023 [doi]
AB  - There are numerous recent studies highlighting sustainability problems for the
      development of ruminant production systems (RPS) while facing increasing human
      food necessities and global climate change. Despite the complexity of the
      context, in our view the main objectives of the ruminants' physiologist should be
      convergent for both industrialized (IC) and developing countries (DC) in a common
      and global strategy of advancing knowledge. In DC, this means improving the
      efficiency of RPS, taking into account the unique possibility of using
      rangelands. For IC settings, RPS should be revisited in terms of autonomy and
      environment- friendly feeding and managing practices. Assuming that competition
      for feed/food use is still a crucial criterion, future ruminant feeding systems
      (FeSyst) should preferably focus on lignocellulosic sources. According to biome
      distributions, and the recent increases in volumes of crop residues and their
      by-products, the annually renewed volumes of these biomasses are considerable.
      Therefore, we need to redesign our strategies for their efficient utilization at 
      the local level. For this purpose, digestion processes and rumen functioning need
      to be better understood. The renewed vision of ruminal digestion through the
      reduction of greenhouse gas emissions is also a key aspect as it is an
      environmental demand that cannot be ignored. With regard to other ruminants'
      physiological functions, accumulated knowledge could be mobilized into an
      integrative approach that puts forward the adaptive capacities of animals to face
      variability in quantity and quality of supplied feeds. Basically, the reduction
      of inputs that were traditionally used to ensure FeSyst will need more flexible
      animals. In that sense, the concepts of homeostasis and teleophorhesis need to be
      updated and adapted to domestic species and breeds that were until now largely
      excluded from the dominant productive systems. In conclusion, a more holistic
      approach of research targets is required in which physiological functions and
      farmers' practices must converge and respond to each particular situation in an
      integral, dynamic and flexible conceptual perspective. From a scientific point of
      view, both for ICs and DCs, a broader range of experimental scenarios should be
      explored in order to arrive at innovative practices and solutions that respect
      environmental, ethical and economical issues. The clear challenge is to in
      evaluate the sustainability of RPSs. This includes, in our opinion, a strong
      interaction with other disciplines (multi- and trans-disciplinary conception),
      thus structuring new relevant indicators for the evaluation sustainability.
FAU - Bocquier, F
AU  - Bocquier F
AD  - 1Montpellier SupAgro, UMR868 ERRC, Batiment 22, Campus SupAgro-INRA, 2 Place
      Pierre Viala, F-34060 Montpellier, France.
FAU - Gonzalez-Garcia, E
AU  - Gonzalez-Garcia E
LA  - eng
PT  - Journal Article
PL  - England
TA  - Animal
JT  - Animal : an international journal of animal bioscience
JID - 101303270
EDAT- 2010/07/01 00:00
MHDA- 2010/07/01 00:01
CRDT- 2012/03/27 06:00
PHST- 2012/03/27 06:00 [entrez]
PHST- 2010/07/01 00:00 [pubmed]
PHST- 2010/07/01 00:01 [medline]
AID - S1751731110001023 [pii]
AID - 10.1017/S1751731110001023 [doi]
PST - ppublish
SO  - Animal. 2010 Jul;4(7):1258-73. doi: 10.1017/S1751731110001023.


PMID- 22444618
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20220317
IS  - 1751-732X (Electronic)
IS  - 1751-7311 (Linking)
VI  - 4
IP  - 7
DP  - 2010 Jul
TI  - Interactions between nutrition and reproduction in the management of the mature
      male ruminant.
PG  - 1214-26
LID - 10.1017/S1751731109991674 [doi]
AB  - In mature male sheep and goats, changes in feed intake seem to have little effect
      on gonadal endocrine function but induce profound changes on sperm production.
      These outcomes are due to changes in size of the seminiferous tubules and in
      spermatogenic efficiency. Except with severe underfeeding, there are only minor
      changes in the endocrine function of the testis (testosterone production) unless 
      season-long treatments are imposed. For cattle, nutrition clearly affects
      testicular development and the production of spermatozoa in young bulls, as it
      does in other species but, after the period of rapid growth has ended, there
      appears to be little or no response to nutrition. We are developing a clear
      picture of the metabolic signals, neuroendocrine processes and hormonal control
      systems that are involved, particularly for the mature male sheep. The energetic 
      components of the diet, rather than protein, seem to be responsible, so we have
      envisaged a model of the relationship between energy balance and reproduction
      that has 4 'dimensions': genotype, structure (organs), communication (chemical
      and neural signals, nutrient sensing) and time (dynamics, metabolic memory,
      programming). We have linked these perspectives to 'resource allocation theory'
      and incorporated them into strategies for 'clean, green and ethical animal
      production'. In contrast to the clear outcomes with respect to spermatogenesis,
      the effects of nutrition on sexual behaviour are more difficult to define,
      perhaps because the behaviour is affected by a complex mix of physiological
      factors and because of flawed methods for quantifying male behaviour. For
      example, sexual behaviour is compromised by severe feed restriction, but male
      sexual behaviour requires intensive motor activity so a decline in libido could
      be caused by general weakness rather than specific nutritional limitations. The
      interaction between sexual activity and feeding behaviour also complicates the
      issue under field conditions. At the other end of the scale, overweight males can
      show reduced sexual success because they have difficulty courting and mounting.
      For this reason, exercise can enhance the fertilising capacity of rams. This will
      be important in extensive mating systems where males need to assemble and guard a
      harem and then mate many times for several weeks. For artificial insemination
      centres, there seems to be very few data on the nutritional management of males, 
      but problems with overfed animals appear to be a risk. Future research should
      concentrate on the intra-testicular systems mediating the effects of nutrition on
      the production of spermatozoa.
FAU - Martin, G B
AU  - Martin GB
AD  - 1UWA Institute of Agriculture M082, The University of Western Australia, Crawley,
      Western Australia 6009, Australia.
FAU - Blache, D
AU  - Blache D
FAU - Miller, D W
AU  - Miller DW
FAU - Vercoe, P E
AU  - Vercoe PE
LA  - eng
PT  - Journal Article
PL  - England
TA  - Animal
JT  - Animal : an international journal of animal bioscience
JID - 101303270
EDAT- 2010/07/01 00:00
MHDA- 2010/07/01 00:01
CRDT- 2012/03/27 06:00
PHST- 2012/03/27 06:00 [entrez]
PHST- 2010/07/01 00:00 [pubmed]
PHST- 2010/07/01 00:01 [medline]
AID - S1751731109991674 [pii]
AID - 10.1017/S1751731109991674 [doi]
PST - ppublish
SO  - Animal. 2010 Jul;4(7):1214-26. doi: 10.1017/S1751731109991674.


PMID- 22135548
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2180-4303 (Electronic)
IS  - 1394-195X (Linking)
VI  - 17
IP  - 3
DP  - 2010 Jul
TI  - Big Sib Students' Perceptions of the Educational Environment at the School of
      Medical Sciences, Universiti Sains Malaysia, using Dundee Ready Educational
      Environment Measure (DREEM) Inventory.
PG  - 40-7
AB  - BACKGROUND: A cross-sectional descriptive study was conducted among Big Sib
      students to explore their perceptions of the educational environment at the
      School of Medical Sciences, Universiti Sains Malaysia (USM) and its weak areas
      using the Dundee Ready Educational Environment Measure (DREEM) inventory. The
      DREEM inventory is a validated global instrument for measuring educational
      environments in undergraduate medical and health professional education. METHOD: 
      The English version of the DREEM inventory was administered to all Year 2 Big Sib
      students (n = 67) at a regular Big Sib session. The purpose of the study as well 
      as confidentiality and ethical issues were explained to the students before the
      questionnaire was administered. RESULTS: The response rate was 62.7% (42 out of
      67 students). The overall DREEM score was 117.9/200 (SD 14.6). The DREEM
      indicated that the Big Sib students' perception of educational environment of the
      medical school was more positive than negative. Nevertheless, the study also
      revealed some problem areas within the educational environment. CONCLUSION: This 
      pilot study revealed that Big Sib students perceived a positive learning
      environment at the School of Medical Sciences, USM. It also identified some
      low-scored areas that require further exploration to pinpoint the exact problems.
      The relatively small study population selected from a particular group of
      students was the major limitation of the study. This small sample size also means
      that the study findings cannot be generalised.
FAU - Arzuman, Hafiza
AU  - Arzuman H
AD  - Department of Medical Education, School of Medical Sciences, Universiti Sains
      Malaysia Health Campus, 16150 Kubang Kerian, Malaysia.
FAU - Yusoff, Muhamad Saiful Bahri
AU  - Yusoff MS
FAU - Chit, Som Phong
AU  - Chit SP
LA  - eng
PT  - Journal Article
PL  - Malaysia
TA  - Malays J Med Sci
JT  - The Malaysian journal of medical sciences : MJMS
JID - 101126308
PMC - PMC3216174
OTO - NOTNLM
OT  - curriculum
OT  - environment
OT  - medical sciences
OT  - medical student
OT  - perception
OT  - questionnaires
EDAT- 2010/07/01 00:00
MHDA- 2010/07/01 00:01
CRDT- 2011/12/03 06:00
PHST- 2009/04/05 00:00 [received]
PHST- 2010/04/28 00:00 [accepted]
PHST- 2011/12/03 06:00 [entrez]
PHST- 2010/07/01 00:00 [pubmed]
PHST- 2010/07/01 00:01 [medline]
PST - ppublish
SO  - Malays J Med Sci. 2010 Jul;17(3):40-7.


PMID- 22043332
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 2070-5204 (Electronic)
IS  - 1999-768X (Linking)
VI  - 25
IP  - 3
DP  - 2010 Jul
TI  - Association between seminal plasma copper and magnesium levels with oxidative
      stress in iraqi infertile men.
PG  - 168-72
LID - 10.5001/omj.2010.51 [doi]
AB  - OBJECTIVES: To study the association between copper, magnesium and
      malondialdehyde levels in seminal plasma of oligozoospermic, azoospermic in
      relation to normozoospermic men. METHODS: The present study was conducted at the 
      Chemistry and Biochemistry department, College of Medicine, Al-Nahrain
      University, Baghdad-Iraq during September 2007 to February 2008 after obtaining
      approval from the research and ethics committee and obtaining written consent, 78
      infertile men (age range 33.01+/-4.20 years) were recruited at the institute of
      embryo research and infertility treatment, Al-Kadhimiya teaching hospital, Iraq
      and were categorized according to their seminal fluid parameters to
      oligozoospermia (n=43) and azoospermia (n=35). 41 fertile men (age range
      30.29+/-2.30 years) were selected as controls. Seminal plasma copper and
      magnesium were measured by atomic absorption spectrophotometry. Malondialdehyde
      was measured calorimetrically using thiobarbituric acid assay which detects
      thiobarbituric acid reactive substances. RESULTS: Seminal plasma copper level was
      decreased significantly (p=0.000) in the azoospermic group compared to the
      control group. Whereas, the level decreased non-significantly in the
      oligozoospermic group. Seminal plasma magnesium levels were decreased
      significantly (p=0.000) in all the infertility groups studied. On the other hand,
      malondialdehyde levels which is an end product of lipid peroxidation were
      significantly elevated (p=0.000) in all the infertility groups studied.
      CONCLUSION: Copper and magnesium work in different ways in order to maintain
      normal environment for spermatozoa for normal fertilization to occur.
FAU - Abdul-Rasheed, Omar F
AU  - Abdul-Rasheed OF
AD  - Department of Chemistry and Biochemistry, College of Medicine/ Al-Nahrain
      University, Al-Kadhimiya- PO. Box: 70027, Baghdad- Iraq.
LA  - eng
PT  - Journal Article
PL  - Oman
TA  - Oman Med J
JT  - Oman medical journal
JID - 101526350
PMC - PMC3191638
EDAT- 2010/07/01 00:00
MHDA- 2010/07/01 00:01
CRDT- 2011/11/02 06:00
PHST- 2010/03/11 00:00 [received]
PHST- 2010/05/12 00:00 [accepted]
PHST- 2011/11/02 06:00 [entrez]
PHST- 2010/07/01 00:00 [pubmed]
PHST- 2010/07/01 00:01 [medline]
AID - 10.5001/omj.2010.51 [doi]
AID - OMJ-D-09-00187 [pii]
PST - ppublish
SO  - Oman Med J. 2010 Jul;25(3):168-72. doi: 10.5001/omj.2010.51.


PMID- 22029103
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20211020
IS  - 1128-2460 (Print)
IS  - 1128-2460 (Linking)
VI  - 29
IP  - 1
DP  - 2010 Jul
TI  - Mendelian bases of myopathies, cardiomyopathies, and neuromyopathies.
PG  - 1-20
AB  - A second genetic revolution is approaching thanks to next-generation DNA
      sequencing technologies. In the next few years, the 1,000$-genome sequencing
      promises to reveal every individual variation of DNA. There is, however, a major 
      problem: the identification of thousands of nucleotide changes per individual
      with uncertain pathological meaning. This is also an ethical issue. In the
      middle, there is today the possibility to address the sequencing analysis of
      genetically heterogeneous disorders to selected groups of genes with defined
      mutation types. This will be cost-effective and safer. We assembled an easy-to
      manage overview of most Mendelian genes involved in myopathies, cardiomyopathies,
      and neuromyopathies. This was entirely put together using a number of open access
      web resources that are listed below. During this effort we realized that there
      are unexpected countless sources of data, but the confusion is huge. In some
      cases, we got lost in the validation of disease genes and in the difficulty to
      discriminate between polymorphisms and disease-causing alleles. In the table are 
      the annotated genes, their associated disorders, genomic, mRNA and coding sizes. 
      We also counted the number of pathological alleles so far reported and the
      percentage of single nucleotide mutations.
FAU - Piluso, G
AU  - Piluso G
AD  - Dipartimento di Patologia Generale, Seconda Universita di Napoli, Naples, Italy.
FAU - Aurino, S
AU  - Aurino S
FAU - Cacciottolo, M
AU  - Cacciottolo M
FAU - Del Vecchio Blanco, F
AU  - Del Vecchio Blanco F
FAU - Lancioni, A
AU  - Lancioni A
FAU - Rotundo, I L
AU  - Rotundo IL
FAU - Torella, A
AU  - Torella A
FAU - Nigro, V
AU  - Nigro V
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - Acta Myol
JT  - Acta myologica : myopathies and cardiomyopathies : official journal of the
      Mediterranean Society of Myology
JID - 9811169
SB  - IM
MH  - Cardiomyopathies/*genetics
MH  - DNA Mutational Analysis
MH  - Genetic Variation
MH  - Genome, Human
MH  - Humans
MH  - Muscular Diseases/*genetics
MH  - Neuromuscular Diseases/*genetics
MH  - Polymorphism, Single Nucleotide
MH  - Polyneuropathies/*genetics
MH  - Sequence Analysis, DNA
PMC - PMC2954584
EDAT- 2010/07/01 00:00
MHDA- 2011/12/13 00:00
CRDT- 2011/10/28 06:00
PHST- 2011/10/28 06:00 [entrez]
PHST- 2010/07/01 00:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PST - ppublish
SO  - Acta Myol. 2010 Jul;29(1):1-20.


PMID- 21992824
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20220211
IS  - 1525-1403 (Electronic)
IS  - 1094-7159 (Linking)
VI  - 13
IP  - 3
DP  - 2010 Jul
TI  - Ethical issues in neuromodulation.
PG  - 147-51
LID - 10.1111/j.1525-1403.2010.00281.x [doi]
FAU - Levy, Robert M
AU  - Levy RM
AD  - Professor of Neurological Surgery, Physiology and Radiation Oncology Feinberg
      School of Medicine, Northwestern University Chicago, IL, USA.
LA  - eng
PT  - Editorial
PL  - United States
TA  - Neuromodulation
JT  - Neuromodulation : journal of the International Neuromodulation Society
JID - 9804159
EDAT- 2010/07/01 00:00
MHDA- 2010/07/01 00:01
CRDT- 2011/10/14 06:00
PHST- 2011/10/14 06:00 [entrez]
PHST- 2010/07/01 00:00 [pubmed]
PHST- 2010/07/01 00:01 [medline]
AID - 10.1111/j.1525-1403.2010.00281.x [doi]
AID - S1094-7159(10)60001-3 [pii]
PST - ppublish
SO  - Neuromodulation. 2010 Jul;13(3):147-51. doi: 10.1111/j.1525-1403.2010.00281.x.


PMID- 21914623
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20140620
IS  - 1105-2333 (Print)
IS  - 1105-2333 (Linking)
VI  - 21
IP  - 3
DP  - 2010 Jul-Sep
TI  - [Thoughts on the philosophy of psychiatric practice].
PG  - 247-53
AB  - Philosophical training within a psychiatric context has been traditionally seen
      as an out- or metapsychiatric activity, not directly associated with the outcomes
      of psychiatric therapeutic interventions, whether they belong to the realm of
      psychoanalysis/psychotherapy or to that of biological psychiatry. Yet,
      psychiatry's subject matter (personal psychopathology), current status of
      scientific knowledge and research, as well as marked inefficiency of many
      psychiatric treatments suggest that we might consider novel ontological,
      epistemological/epistemic, and ethical parameters that could both enrich
      psychiatric philosophical thought and enhance psychiatric therapeutic practice by
      rendering it more efficient. Within a realistic empiricist context, in view of
      revising currently used diagnostic manuals (DSM-IV and ICD-10), related
      discourses are proposed to focus upon doctor-patient relationship. This raises
      ontological (diagnostic, nosographical), epistemological (related to contexts,
      boundaries, and methods of psychiatric knowledge), and ethical questions (as per 
      moral significance of both quality and fullness of doctor-patient relationship
      regarding outcomes of treatment administered), which, in their turn till now are 
      either ignored or superficially dealt with by traditional biomedical -psychiatric
      in particular- philosophy. Within this context, certain suggestions are offered
      towards a renewal of psychiatric philosophical thought by indicating novel
      research orientations for scrutiny, with the aim to optimize psychiatric
      practice.
FAU - Koutouvidis, N I
AU  - Koutouvidis NI
AD  - Psychiatric Department, NIMTS Hospital, Athens, Greece.
LA  - gre
PT  - English Abstract
PT  - Journal Article
PL  - Greece
TA  - Psychiatriki
JT  - Psychiatrike = Psychiatriki
JID - 101534363
EDAT- 2010/07/01 00:00
MHDA- 2010/07/01 00:01
CRDT- 2011/09/15 06:00
PHST- 2011/09/15 06:00 [entrez]
PHST- 2010/07/01 00:00 [pubmed]
PHST- 2010/07/01 00:01 [medline]
PST - ppublish
SO  - Psychiatriki. 2010 Jul-Sep;21(3):247-53.


PMID- 20585315
OWN - NLM
STAT- MEDLINE
DCOM- 20101007
LR  - 20211020
IS  - 1759-507X (Electronic)
IS  - 1759-5061 (Linking)
VI  - 6
IP  - 7
DP  - 2010 Jul
TI  - Transplantation: Pediatric kidney donation after cardiac death.
PG  - 387-8
LID - 10.1038/nrneph.2010.40 [doi]
AB  - A Dutch study has evaluated the outcomes after transplantation of kidneys from
      pediatric patients after cardiac death. Such programs instigate ethical debate
      regarding the classification of donors, and raise questions about the suitability
      of protocols for determining when an individual can be declared dead, and thus,
      can donate their organs.
FAU - Sung, Randall S
AU  - Sung RS
LA  - eng
PT  - News
PL  - England
TA  - Nat Rev Nephrol
JT  - Nature reviews. Nephrology
JID - 101500081
SB  - IM
MH  - Child
MH  - *Death
MH  - Humans
MH  - Kidney Transplantation/*ethics
MH  - Tissue Donors/*ethics
MH  - Tissue and Organ Procurement/*ethics
EDAT- 2010/06/30 06:00
MHDA- 2010/10/12 06:00
CRDT- 2010/06/30 06:00
PHST- 2010/06/30 06:00 [entrez]
PHST- 2010/06/30 06:00 [pubmed]
PHST- 2010/10/12 06:00 [medline]
AID - nrneph.2010.40 [pii]
AID - 10.1038/nrneph.2010.40 [doi]
PST - ppublish
SO  - Nat Rev Nephrol. 2010 Jul;6(7):387-8. doi: 10.1038/nrneph.2010.40.


PMID- 20585241
OWN - NLM
STAT- MEDLINE
DCOM- 20101021
LR  - 20131121
IS  - 1473-6322 (Electronic)
IS  - 1473-6322 (Linking)
VI  - 10
IP  - 4
DP  - 2010 Aug
TI  - Pharmacologic treatment of anaphylaxis: can the evidence base be strengthened?
PG  - 384-93
LID - 10.1097/ACI.0b013e32833c2038 [doi]
AB  - PURPOSE OF REVIEW: To evaluate the evidence base for the pharmacologic treatment 
      of anaphylaxis. RECENT FINDINGS: In this review, we focus on four classes of
      medications (the alpha/beta-agonist epinephrine (adrenaline), H1-antihistamines, 
      H2-antihistamines, and glucocorticoids) that are used in healthcare settings for 
      the initial treatment of anaphylaxis. Epinephrine and many H1-antihistamines and 
      glucocorticoids were introduced before the era of randomized controlled trials
      and before the era of evidence-based medicine. In anaphylaxis, no randomized
      controlled trials that are free from methodological problems and meet current
      standards have been performed with these medications, or with H2-antihistamines. 
      The evidence base for epinephrine injection is stronger than the evidence base
      for use of other medications in anaphylaxis. Guidelines unanimously recommend
      prompt injection of epinephrine as the life-saving first-line medication in
      anaphylaxis; however, they differ in their recommendations for H1-antihistamines,
      H2-antihistamines, and glucocorticoids. Epinephrine is the only medication that
      is universally available for anaphylaxis treatment in healthcare settings
      worldwide. Paradoxically, it is underused in anaphylaxis treatment. SUMMARY: For 
      ethical reasons, there should never be a placebo-controlled trial of epinephrine 
      in anaphylaxis. We discuss why the possibility of conducting randomized
      placebo-controlled trials with H1-antihistamines, H2-antihistamines, and
      particularly with glucocorticoids in anaphylaxis should be considered in order to
      improve the evidence base for treatment and guide clinical decision-making. We
      also describe the precautions that will be needed if randomized controlled trials
      are conducted in anaphylaxis.
FAU - Simons, F Estelle R
AU  - Simons FE
AD  - Department of Pediatrics & Child Health, Department of Immunology, Faculty of
      Medicine, University of Manitoba, Winnipeg, Manitoba, Canada. lmcniven@hsc.mb.ca
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Allergy Clin Immunol
JT  - Current opinion in allergy and clinical immunology
JID - 100936359
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Glucocorticoids)
RN  - 0 (Histamine H1 Antagonists)
RN  - 0 (Histamine H2 Antagonists)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Anaphylaxis/*drug therapy
MH  - Anti-Allergic Agents/administration & dosage/*therapeutic use
MH  - Epinephrine/administration & dosage/*therapeutic use
MH  - *Evidence-Based Medicine
MH  - Glucocorticoids/administration & dosage/*therapeutic use
MH  - Histamine H1 Antagonists/administration & dosage/*therapeutic use
MH  - Histamine H2 Antagonists/administration & dosage/*therapeutic use
MH  - Humans
MH  - Practice Guidelines as Topic
MH  - Randomized Controlled Trials as Topic
MH  - Treatment Outcome
EDAT- 2010/06/30 06:00
MHDA- 2010/10/22 06:00
CRDT- 2010/06/30 06:00
PHST- 2010/06/30 06:00 [entrez]
PHST- 2010/06/30 06:00 [pubmed]
PHST- 2010/10/22 06:00 [medline]
AID - 10.1097/ACI.0b013e32833c2038 [doi]
PST - ppublish
SO  - Curr Opin Allergy Clin Immunol. 2010 Aug;10(4):384-93. doi:
      10.1097/ACI.0b013e32833c2038.


PMID- 20584919
OWN - NLM
STAT- MEDLINE
DCOM- 20100927
LR  - 20211020
IS  - 1942-5546 (Electronic)
IS  - 0025-6196 (Linking)
VI  - 85
IP  - 9
DP  - 2010 Sep
TI  - Ethical analysis of withdrawing ventricular assist device support.
PG  - 791-7
LID - 10.4065/mcp.2010.0113 [doi]
AB  - OBJECTIVE: To describe a series of patients with heart failure supported with a
      ventricular assist device (VAD) who requested (or whose surrogates requested)
      withdrawal of VAD support and the legal and ethical aspects pertaining to these
      requests. PATIENTS AND METHODS: We retrospectively reviewed the medical records
      of patients at Mayo Clinic, Rochester, MN, from March 1, 2003, through January
      31, 2009, who requested (or whose surrogates requested) withdrawal of VAD support
      and for whom the requests were fulfilled. We then explored the legal and ethical 
      permissibility of carrying out such requests. RESULTS: The median age of the 14
      patients identified (13 men, 1 woman) was 57 years. Requests were made by 2
      patients and 12 surrogates. None of the patients' available advance directives
      mentioned the VAD. For 11 patients, multidisciplinary care conferences were held 
      before withdrawal of VAD support. Only 1 patient had an ethics consultation. All 
      14 patients died within 1 day of withdrawal of VAD support. CONCLUSION: Patients 
      have the right to refuse or request the withdrawal of any unwanted treatment, and
      we argue that this right extends to VAD support. We also argue that the cause of 
      death in these cases is the underlying heart disease, not assisted suicide or
      euthanasia. Therefore, patients with heart failure supported with VADs or their
      surrogates may request withdrawal of this treatment. In our view, carrying out
      such requests is permissible in accordance with the principles that apply to
      withdrawing other life-sustaining treatments.
FAU - Mueller, Paul S
AU  - Mueller PS
AD  - Division of General Internal Medicine, Mayo Clinic, 200 First St SW, Rochester,
      MN 55905, USA. mueller.pauls@mayo.edu
FAU - Swetz, Keith M
AU  - Swetz KM
FAU - Freeman, Monica R
AU  - Freeman MR
FAU - Carter, Kari A
AU  - Carter KA
FAU - Crowley, Mary Eliot
AU  - Crowley ME
FAU - Severson, Cathy J Anderson
AU  - Severson CJ
FAU - Park, Soon J
AU  - Park SJ
FAU - Sulmasy, Daniel P
AU  - Sulmasy DP
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20100628
PL  - England
TA  - Mayo Clin Proc
JT  - Mayo Clinic proceedings
JID - 0405543
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Heart Diseases/therapy
MH  - Heart-Assist Devices/*ethics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Suicide, Assisted/ethics
MH  - Third-Party Consent/ethics
MH  - Treatment Refusal/ethics
MH  - Withholding Treatment/*ethics
PMC - PMC2931614
EDAT- 2010/06/30 06:00
MHDA- 2010/09/29 06:00
CRDT- 2010/06/30 06:00
PHST- 2010/06/30 06:00 [entrez]
PHST- 2010/06/30 06:00 [pubmed]
PHST- 2010/09/29 06:00 [medline]
AID - S0025-6196(11)60209-7 [pii]
AID - 10.4065/mcp.2010.0113 [doi]
PST - ppublish
SO  - Mayo Clin Proc. 2010 Sep;85(9):791-7. doi: 10.4065/mcp.2010.0113. Epub 2010 Jun
      28.


PMID- 20584332
OWN - NLM
STAT- MEDLINE
DCOM- 20100830
LR  - 20211020
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 11
DP  - 2010 Jun 28
TI  - Identifying structures, processes, resources and needs of research ethics
      committees in Egypt.
PG  - 12
LID - 10.1186/1472-6939-11-12 [doi]
AB  - BACKGROUND: Concerns have been expressed regarding the adequacy of ethics review 
      systems in developing countries. Limited data are available regarding the
      structural and functional status of Research Ethics Committees (RECs) in the
      Middle East. The purpose of this study was to survey the existing RECs in Egypt
      to better understand their functioning status, perceived resource needs, and
      challenges. METHODS: We distributed a self-administered survey tool to Egyptian
      RECs to collect information on the following domains: general characteristics of 
      the REC, membership composition, ethics training, workload, process of ethics
      review, perceived challenges to effective functioning, and financial and material
      resources. We used basic descriptive statistics to evaluate the quantitative
      data. RESULTS: We obtained responses from 67% (12/18) of the identified RECs.
      Most RECs (10/12) have standard operating procedures and many (7/12) have
      established policies to manage conflicts of interests. The average membership was
      10.3 with a range from 7-19. The predominant member type was physicians (69.5% of
      all of the REC members) with little lay representation (13.7%). Most RECs met at 
      least once/month and the average number of protocols reviewed per meeting was 3.8
      with a range from 1-10. Almost three-quarters of the members from all of the 12
      RECs indicated they received some formal training in ethics. Regarding resources,
      roughly half of the RECs have dedicated capital equipment (e.g., meeting room,
      computers, office furniture, etc); none of the RECs have a formal operating
      budget. Perceived challenges included the absence of national research ethics
      guidelines and national standards for RECs and lack of ongoing training of its
      members in research ethics. CONCLUSION: Our study documents several areas of
      strengths and areas for improvements in the operations of Egyptian RECs.
      Regarding strengths, many of the existing RECs meet frequently, have a majority
      of members with prior training in research ethics, and have written policies.
      Regarding areas for improvements, many RECs should strive for a more diverse
      membership and should receive more financial resources and administrative support
      personnel. We recommend that RECs include more individuals from the community and
      develop a continuing educational program for its members. Institutional officials
      should be aware of the resource capacity needs of their RECs.
FAU - Sleem, Hany
AU  - Sleem H
AD  - National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt.
FAU - El-Kamary, Samer S
AU  - El-Kamary SS
FAU - Silverman, Henry J
AU  - Silverman HJ
LA  - eng
GR  - R25TW007090/TW/FIC NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100628
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Adult
MH  - Cross-Sectional Studies
MH  - Egypt
MH  - *Ethics Committees, Research/economics/organization &
      administration/standards/statistics & numerical data/trends
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Needs Assessment
MH  - Surveys and Questionnaires
MH  - Workload
PMC - PMC2908628
EDAT- 2010/06/30 06:00
MHDA- 2010/08/31 06:00
CRDT- 2010/06/30 06:00
PHST- 2010/02/22 00:00 [received]
PHST- 2010/06/28 00:00 [accepted]
PHST- 2010/06/30 06:00 [entrez]
PHST- 2010/06/30 06:00 [pubmed]
PHST- 2010/08/31 06:00 [medline]
AID - 1472-6939-11-12 [pii]
AID - 10.1186/1472-6939-11-12 [doi]
PST - epublish
SO  - BMC Med Ethics. 2010 Jun 28;11:12. doi: 10.1186/1472-6939-11-12.


PMID- 22371773
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20220311
IS  - 1896-9151 (Electronic)
IS  - 1734-1922 (Linking)
VI  - 6
IP  - 3
DP  - 2010 Jun 30
TI  - Determining entropy values equivalent to the bispectral index values during
      sevoflurane anaesthesia.
PG  - 370-4
LID - 10.5114/aoms.2010.14257 [doi]
AB  - INTRODUCTION: We aimed to identify the entropy levels that would be equivalent to
      the bispectral index (BIS) levels in sevoflurane anaesthesia in patients who are 
      to undergo elective lumbar disc surgery. MATERIAL AND METHODS: Thirty cases in
      ASA groups I-II who underwent lumbar disc surgery under general anaesthesia were 
      included in our study after obtaining the consent of the patients and Ethics
      Committee of our medical school between January 1, 2005 and October 30, 2006. BIS
      and entropy electrodes were applied at the same time in 30 cases in the study
      group. The depth of the anaesthesia was regulated so that 10 min after beginning 
      the general anaesthesia the BIS values were between 40 and 60. At the same time
      equivalent entropy values corresponding to BIS values were obtained. RESULTS: At 
      the end of the study, entropy values corresponding to general anaesthesia BIS
      values were identified. General anaesthesia BIS and RE/SE values at 10 min were
      lower than the values of the control, which was statistically significant (p <
      0.05). Equivalent entropy values were obtained lower than the BIS values during
      general anaesthesia and these values were found to be statistically significant
      (p < 0.05). The blood pressure (BP) values obtained were very low at equivalent
      BIS values and when these BP values were compared with the initial BP values they
      were found to be statistically significant (p < 0.05). CONCLUSIONS: Based on this
      observation, we think that general anaesthetic agents that might cause severe
      hypotension could be more safely administered under entropy monitoring.
FAU - Balci, Canan
AU  - Balci C
AD  - Medicine Faculty, Afyon Kocatepe University, Turkey.
FAU - Karabekir, Hamit
AU  - Karabekir H
FAU - Sivaci, Remziye
AU  - Sivaci R
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - Arch Med Sci
JT  - Archives of medical science : AMS
JID - 101258257
PMC - PMC3282514
OTO - NOTNLM
OT  - bispectral index
OT  - entropy
OT  - general anaesthesia
EDAT- 2010/06/30 00:00
MHDA- 2010/06/30 00:01
CRDT- 2012/02/29 06:00
PHST- 2009/05/29 00:00 [received]
PHST- 2009/06/17 00:00 [revised]
PHST- 2009/08/06 00:00 [accepted]
PHST- 2012/02/29 06:00 [entrez]
PHST- 2010/06/30 00:00 [pubmed]
PHST- 2010/06/30 00:01 [medline]
AID - 10.5114/aoms.2010.14257 [doi]
AID - 14977 [pii]
PST - ppublish
SO  - Arch Med Sci. 2010 Jun 30;6(3):370-4. doi: 10.5114/aoms.2010.14257.


PMID- 20583190
OWN - NLM
STAT- MEDLINE
DCOM- 20100929
LR  - 20211020
IS  - 1552-4833 (Electronic)
IS  - 1552-4825 (Linking)
VI  - 152A
IP  - 7
DP  - 2010 Jul
TI  - The right to ignore genetic status of late onset genetic disease in the genomic
      era; Prenatal testing for Huntington disease as a paradigm.
PG  - 1774-80
LID - 10.1002/ajmg.a.33432 [doi]
AB  - During the last decade, the field of human genome research has gone through a
      phase of rapid discovery that has provided scientists and physicians with a wide 
      variety of research tools that are applicable to important medical issues. We
      describe a true case of familial Huntington disease (HD) in which we modified
      personal details to protect patient's privacy, where the proband at risk
      preferred not to know his disease status but wanted to know the status in his
      unborn child. Once we found the father to be negative, the case raised an
      important ethical question regarding the management of this as well as future
      pregnancies. This article discusses the arguments for and against the right not
      to know of one's carrier status, as well as professional obligations in the
      context of withholding unwanted information that may have direct implications not
      only for the patient himself but also for other family members. HD has served as 
      a model for many other adult onset genetic diseases in terms of carrier testing
      guidelines. Hence, we feel it is time to revisit the issue of prenatal testing
      for HD and consider updating the current recommendations regarding the patient's 
      right to "genetic ignorance", or the right not to know genetic information.
CI  - (c) 2010 Wiley-Liss, Inc.
FAU - Erez, A
AU  - Erez A
AD  - Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, 
      Texas 77030, USA.
FAU - Plunkett, K
AU  - Plunkett K
FAU - Sutton, V R
AU  - Sutton VR
FAU - McGuire, A L
AU  - McGuire AL
LA  - eng
GR  - K08 DK081735-01A1/DK/NIDDK NIH HHS/United States
GR  - T32GM07526/GM/NIGMS NIH HHS/United States
GR  - R01 HG004333/HG/NHGRI NIH HHS/United States
GR  - T32 GM007526/GM/NIGMS NIH HHS/United States
GR  - DK081735-01A1/DK/NIDDK NIH HHS/United States
GR  - R01 HG004853/HG/NHGRI NIH HHS/United States
GR  - K08 DK081735/DK/NIDDK NIH HHS/United States
GR  - T32 GM007526-32/GM/NIGMS NIH HHS/United States
GR  - R01 HG004333-03/HG/NHGRI NIH HHS/United States
GR  - R01 HG004853-01A1/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Med Genet A
JT  - American journal of medical genetics. Part A
JID - 101235741
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Decision Making
MH  - Ethics, Professional
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - *Genomics
MH  - Guidelines as Topic
MH  - *Health Status
MH  - Humans
MH  - Huntington Disease/*diagnosis/epidemiology/*genetics
MH  - Patient Rights/*ethics
MH  - Prenatal Diagnosis/*ethics
MH  - Risk Factors
PMC - PMC3648842
MID - NIHMS461980
EDAT- 2010/06/29 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/06/29 06:00
PHST- 2010/06/29 06:00 [entrez]
PHST- 2010/06/29 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - 10.1002/ajmg.a.33432 [doi]
PST - ppublish
SO  - Am J Med Genet A. 2010 Jul;152A(7):1774-80. doi: 10.1002/ajmg.a.33432.


PMID- 20583083
OWN - NLM
STAT- MEDLINE
DCOM- 20101102
LR  - 20100701
IS  - 1527-6473 (Electronic)
IS  - 1527-6465 (Linking)
VI  - 16
IP  - 7
DP  - 2010 Jul
TI  - Reply: Ethical perspectives on living donor organ transplantation in Asia.
PG  - 917; author reply 918
LID - 10.1002/lt.22078 [doi]
FAU - Omar, Faisal
AU  - Omar F
FAU - Welin, Stellan
AU  - Welin S
FAU - Tufveson, Gunnar
AU  - Tufveson G
LA  - eng
PT  - Comment
PT  - Letter
PL  - United States
TA  - Liver Transpl
JT  - Liver transplantation : official publication of the American Association for the 
      Study of Liver Diseases and the International Liver Transplantation Society
JID - 100909185
SB  - IM
CON - Liver Transpl. 2009 Dec;15(12):1658-61. PMID: 19938130
MH  - Asia
MH  - Compensation and Redress/*ethics/legislation & jurisprudence
MH  - Humans
MH  - Kidney Transplantation/*economics
MH  - Living Donors/*ethics
MH  - Sweden
EDAT- 2010/06/29 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/06/29 06:00
PHST- 2010/06/29 06:00 [entrez]
PHST- 2010/06/29 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - 10.1002/lt.22078 [doi]
PST - ppublish
SO  - Liver Transpl. 2010 Jul;16(7):917; author reply 918. doi: 10.1002/lt.22078.


PMID- 20582827
OWN - NLM
STAT- MEDLINE
DCOM- 20100719
LR  - 20191210
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 7
DP  - 2010 Jul
TI  - Sex, romance, and research subjects: an ethical exploration.
PG  - 30-8
LID - 10.1080/15265161.2010.485672 [doi]
AB  - Professional standards in medicine and psychology treat concurrent sexual
      relationships with patients as violations of fiduciary trust, and they sometimes 
      rule out sexual relationships even after a clinical relationship is over. These
      standards also rule out sex with research subjects who are also patients, but
      what about nonclinical relationships where there are not always parallels to the 
      standards of clinical medicine? One way to treat sex in nonclinical research
      relationships is to treat it as sex is treated elsewhere among adults, as a
      matter of individual choice and responsibility. Alternately, one could ask
      oversight bodies to draw lines between research that can safely accommodate
      sexual relationships and research that cannot. One could even ask researchers to 
      avoid all concurrent sexual relationships with their research participants, as
      happens in clinical medicine. Each of these options has drawbacks that undermine 
      its value as a definitive solution. The deficiencies of these options highlight
      the need for a professional code of conduct for nonclinical researchers.
FAU - Murphy, Timothy F
AU  - Murphy TF
AD  - Department of Medical Education, University of Illinois College of Medicine at
      Chicago, 808 S. Wood St., Chicago, IL 60612-7309, USA. tmurphy@uic.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CIN - Am J Bioeth. 2010 Jul;10(7):W4-5. PMID: 20582816
CIN - Am J Bioeth. 2010 Jul;10(7):39-41. PMID: 20582828
CIN - Am J Bioeth. 2010 Jul;10(7):41-2. PMID: 20582829
CIN - Am J Bioeth. 2010 Jul;10(7):43-4. PMID: 20582830
MH  - American Medical Association
MH  - *Codes of Ethics
MH  - Coitus
MH  - Confidentiality
MH  - Ethical Analysis
MH  - *Ethics, Research
MH  - Female
MH  - Humans
MH  - Licensure
MH  - Male
MH  - Power, Psychological
MH  - Research Personnel/*ethics
MH  - *Research Subjects
MH  - Researcher-Subject Relations/*ethics/psychology
MH  - Sexual Behavior/*ethics/psychology
MH  - Sexual Harassment/ethics/legislation & jurisprudence/psychology
MH  - Sexual Partners/psychology
MH  - Social Responsibility
MH  - *Trust
MH  - United States
EDAT- 2010/06/29 06:00
MHDA- 2010/07/20 06:00
CRDT- 2010/06/29 06:00
PHST- 2010/06/29 06:00 [entrez]
PHST- 2010/06/29 06:00 [pubmed]
PHST- 2010/07/20 06:00 [medline]
AID - 923317997 [pii]
AID - 10.1080/15265161.2010.485672 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Jul;10(7):30-8. doi: 10.1080/15265161.2010.485672.


PMID- 20582815
OWN - NLM
STAT- MEDLINE
DCOM- 20100719
LR  - 20101118
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 7
DP  - 2010 Jul
TI  - Should human beings have sex? Sexual dimorphism and human enhancement.
PG  - 3-12
LID - 10.1080/15265161.2010.489409 [doi]
AB  - Since the first sex reassignment operations were performed, individual sex has
      come to be, to some extent at least, a technological artifact. The existence of
      sperm sorting technology, and of prenatal determination of fetal sex via
      ultrasound along with the option of termination, means that we now have the power
      to choose the sex of our children. An influential contemporary line of thought
      about medical ethics suggests that we should use technology to serve the welfare 
      of individuals and to remove limitations on the opportunities available to them. 
      I argue that, if these are our goals, we may do well to move towards a "post sex"
      humanity. Until we have the technology to produce genuine hermaphrodites, the
      most efficient way to do this is to use sex selection technology to ensure that
      only girl children are born. There are significant restrictions on the
      opportunities available to men, around gestation, childbirth, and breast-feeding,
      which will be extremely difficult to overcome via social or technological
      mechanisms for the foreseeable future. Women also have longer life expectancies
      than men. Girl babies therefore have a significantly more "open" future than boy 
      babies. Resisting the conclusion that we should ensure that all children are born
      the same sex will require insisting that sexual difference is natural to human
      beings and that we should not use technology to reshape humanity beyond certain
      natural limits. The real concern of my paper, then, is the moral significance of 
      the idea of a normal human body in modern medicine.
FAU - Sparrow, Robert
AU  - Sparrow R
AD  - Centre for Human Bioethics, Monash University, Clayton, Victoria 3800, Australia.
      robert.sparrow@arts.monash.edu.au
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CIN - Am J Bioeth. 2010 Jul;10(7):W1-3. PMID: 20582814
CIN - Am J Bioeth. 2010 Jul;10(7):13-4. PMID: 20582818
CIN - Am J Bioeth. 2010 Jul;10(7):15. PMID: 20582819
CIN - Am J Bioeth. 2010 Jul;10(7):16-8. PMID: 20582820
CIN - Am J Bioeth. 2010 Jul;10(7):18-20. PMID: 20582821
CIN - Am J Bioeth. 2010 Jul;10(7):20-2. PMID: 20582822
CIN - Am J Bioeth. 2010 Jul;10(7):22-4. PMID: 20582823
CIN - Am J Bioeth. 2010 Jul;10(7):24-5. PMID: 20582824
CIN - Am J Bioeth. 2010 Jul;10(7):26-7. PMID: 20582825
CIN - Am J Bioeth. 2010 Jul;10(7):27-9. PMID: 20582826
MH  - *Beneficence
MH  - Biomedical Enhancement/*ethics
MH  - Choice Behavior/*ethics
MH  - *Disorders of Sex Development
MH  - Ethical Analysis
MH  - Ethical Theory
MH  - Female
MH  - *Gender Identity
MH  - Human Body
MH  - Humans
MH  - Life Expectancy
MH  - Male
MH  - *Moral Obligations
MH  - *Parents
MH  - Parturition
MH  - *Public Policy
MH  - Reproduction
MH  - Sex
MH  - Sex Characteristics
MH  - Sex Preselection/*ethics
MH  - *Sexuality
EDAT- 2010/06/29 06:00
MHDA- 2010/07/20 06:00
CRDT- 2010/06/29 06:00
PHST- 2010/06/29 06:00 [entrez]
PHST- 2010/06/29 06:00 [pubmed]
PHST- 2010/07/20 06:00 [medline]
AID - 923305121 [pii]
AID - 10.1080/15265161.2010.489409 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Jul;10(7):3-12. doi: 10.1080/15265161.2010.489409.


PMID- 20581922
OWN - NLM
STAT- MEDLINE
DCOM- 20100722
LR  - 20220410
IS  - 1175-8716 (Electronic)
IS  - 0028-8446 (Linking)
VI  - 123
IP  - 1314
DP  - 2010 May 14
TI  - In search of professionalism: implications for medical education.
PG  - 123-32
AB  - This is the seventh article in an education series, discussing some of the 'hot
      topics' in teaching and learning in medicine. Historically, 'professionalism' was
      defined by the social structures of medicine, but has moved on to represent the
      expected behaviours and attributes of practitioners. Well publicised cases of
      professional misconduct, the rise of medical ethics as a discipline, and the move
      to a more patient-centred approach have driven the profile of professionalism
      into mainstream medical education. While there are many definitions of medical
      professionalism, there is a growing degree of consensus around what it
      encompasses; the way we manage tasks, our interactions with others, and looking
      after ourselves. The literature indicates that professionalism can be taught,
      learnt and applied; that attributes and behaviours can be identified; and that
      assessment is best approached using a range of methods over time. For learners,
      one of the critical factors in developing professionalism is the modelling by
      senior members of the profession as students move from peripheral observers to
      legitimate participants. Medical programmes in New Zealand are engaging with this
      literature in developing current curricula.
FAU - Wearn, Andy
AU  - Wearn A
AD  - Clinical Skills Centre, Faculty of Medical and Health Sciences, The University of
      Auckland, Auckland, New Zealand. a.wearn@auckland.ac.nz
FAU - Wilson, Hamish
AU  - Wilson H
FAU - Hawken, Susan J
AU  - Hawken SJ
FAU - Child, Stephen
AU  - Child S
FAU - Mitchell, Clinton J
AU  - Mitchell CJ
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100514
PL  - New Zealand
TA  - N Z Med J
JT  - The New Zealand medical journal
JID - 0401067
SB  - IM
CIN - N Z Med J. 2010 Jun 11;123(1316):130. PMID: 20648110
MH  - Education, Medical/*standards
MH  - *Guidelines as Topic
MH  - Humans
MH  - New Zealand
MH  - Professional Competence/*standards
RF  - 42
EDAT- 2010/06/29 06:00
MHDA- 2010/07/23 06:00
CRDT- 2010/06/29 06:00
PHST- 2010/06/29 06:00 [entrez]
PHST- 2010/06/29 06:00 [pubmed]
PHST- 2010/07/23 06:00 [medline]
PST - epublish
SO  - N Z Med J. 2010 May 14;123(1314):123-32.


PMID- 20581910
OWN - NLM
STAT- MEDLINE
DCOM- 20100722
LR  - 20220316
IS  - 1175-8716 (Electronic)
IS  - 0028-8446 (Linking)
VI  - 123
IP  - 1314
DP  - 2010 May 14
TI  - Sickness presenteeism in a New Zealand hospital.
PG  - 31-42
AB  - AIMS: The aim of this study was to assess the attitudes of hospital clinical
      staff to acute personal illness. METHODS: A self-reported questionnaire was
      developed. Four hundred clinical staff employed by the district health board
      (DHB) who met the inclusion criteria who were randomly selected. Data were
      collected and analysed using SPSS software. Ethical approval was obtained from
      the Lower South Regional Ethics Committee and from the DHB Health Research
      Office. RESULTS: Doctors were more likely to exhibit sickness presenteeism
      (SP)--i.e. working despite being sick--than any other occupational group at the
      DHB. Two main reasons were given for not taking sick leave: staff did not believe
      they were unwell enough to justify taking leave and they did not want to increase
      the workload of others. The majority of study participants would not contact
      anyone for advice about whether to take leave. CONCLUSION: This study provides
      evidence that SP, especially in doctors, is prevalent in the DHB and is similar
      to findings from elsewhere. Low rates of clinical staff contacting someone for
      advice on coming to work whilst ill could be targeted to improve infection
      control.
FAU - Bracewell, Lisa M
AU  - Bracewell LM
AD  - Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
FAU - Campbell, Duncan I
AU  - Campbell DI
FAU - Faure, Palmira R
AU  - Faure PR
FAU - Giblin, Emily R
AU  - Giblin ER
FAU - Morris, Tessa A
AU  - Morris TA
FAU - Satterthwaite, Liyana B
AU  - Satterthwaite LB
FAU - Simmers, Cameron D A
AU  - Simmers CD
FAU - Ulrich, Caroline M
AU  - Ulrich CM
FAU - Holmes, John D
AU  - Holmes JD
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20100514
PL  - New Zealand
TA  - N Z Med J
JT  - The New Zealand medical journal
JID - 0401067
SB  - IM
MH  - Adult
MH  - *Attitude to Health
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Infections/*epidemiology
MH  - Male
MH  - *Medical Staff, Hospital
MH  - Middle Aged
MH  - New Zealand/epidemiology
MH  - Personnel Downsizing/trends
MH  - Retrospective Studies
MH  - Sick Leave/*trends
MH  - *Sickness Impact Profile
MH  - Surveys and Questionnaires
MH  - Workload/*statistics & numerical data
EDAT- 2010/06/29 06:00
MHDA- 2010/07/23 06:00
CRDT- 2010/06/29 06:00
PHST- 2010/06/29 06:00 [entrez]
PHST- 2010/06/29 06:00 [pubmed]
PHST- 2010/07/23 06:00 [medline]
PST - epublish
SO  - N Z Med J. 2010 May 14;123(1314):31-42.


PMID- 20581901
OWN - NLM
STAT- MEDLINE
DCOM- 20100722
LR  - 20100628
IS  - 1175-8716 (Electronic)
IS  - 0028-8446 (Linking)
VI  - 123
IP  - 1313
DP  - 2010 Apr 30
TI  - Simple suggestions to improve New Zealand Ethical Committees.
PG  - 93-4
FAU - Holt, Shaun
AU  - Holt S
FAU - Horne, Geoffrey
AU  - Horne G
LA  - eng
PT  - Letter
DEP - 20100430
PL  - New Zealand
TA  - N Z Med J
JT  - The New Zealand medical journal
JID - 0401067
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Ethics Committees, Research/standards/*trends
MH  - Ethics, Medical
MH  - *Guidelines as Topic
MH  - Humans
MH  - New Zealand
EDAT- 2010/06/29 06:00
MHDA- 2010/07/23 06:00
CRDT- 2010/06/29 06:00
PHST- 2010/06/29 06:00 [entrez]
PHST- 2010/06/29 06:00 [pubmed]
PHST- 2010/07/23 06:00 [medline]
PST - epublish
SO  - N Z Med J. 2010 Apr 30;123(1313):93-4.


PMID- 20581423
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20220129
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 8
DP  - 2010 Aug
TI  - Acceptability of offering financial incentives to achieve medication adherence in
      patients with severe mental illness: a focus group study.
PG  - 463-8
LID - 10.1136/jme.2009.035071 [doi]
AB  - BACKGROUND: Offering financial incentives to achieve medication adherence in
      patients with severe mental illness is controversial. AIMS: To explore the views 
      of different stakeholders on the ethical acceptability of the practice. METHOD:
      Focus group study consisting of 25 groups with different stakeholders. RESULTS:
      Eleven themes dominated the discussions and fell into four categories: (1) 'wider
      concerns', including the value of medication, source of funding, how patients
      would use the money, and a presumed government agenda behind the idea; (2)
      'problems requiring clear policies', comprising of practicalities and assurance
      that incentives are only one part of a tool kit; (3) 'challenges for research and
      experience', including effectiveness, the possibility of perverse incentives, and
      impact on the therapeutic relationship; (4) 'inherent dilemmas' around fairness
      and potential coercion. CONCLUSIONS: The use of financial incentives is likely to
      raise similar concerns in most stakeholders, only some of which can be addressed 
      by empirical research and clear policies.
FAU - Priebe, Stefan
AU  - Priebe S
AD  - Queen Mary University of London, Unit for Social and Community Psychiatry, Newham
      Centre for Mental Health, London, UK. s.priebe@qmul.ac.uk
FAU - Sinclair, Julia
AU  - Sinclair J
FAU - Burton, Alexandra
AU  - Burton A
FAU - Marougka, Stamatina
AU  - Marougka S
FAU - Larsen, John
AU  - Larsen J
FAU - Firn, Mike
AU  - Firn M
FAU - Ashcroft, Richard
AU  - Ashcroft R
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - 07/60/43/DH_/Department of Health/United Kingdom
GR  - 081433/Z/06/Z/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100627
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
RN  - 0 (Antipsychotic Agents)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antipsychotic Agents/economics/*therapeutic use
MH  - Cost-Benefit Analysis
MH  - Female
MH  - Focus Groups
MH  - Humans
MH  - Male
MH  - Medication Adherence/*psychology
MH  - Mental Disorders/*drug therapy/economics
MH  - Middle Aged
MH  - *Motivation
MH  - *Reward
MH  - United Kingdom
MH  - Young Adult
PMC - PMC2976611
EDAT- 2010/06/29 06:00
MHDA- 2011/11/09 06:00
CRDT- 2010/06/29 06:00
PHST- 2010/06/29 06:00 [entrez]
PHST- 2010/06/29 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - jme.2009.035071 [pii]
AID - 10.1136/jme.2009.035071 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Aug;36(8):463-8. doi: 10.1136/jme.2009.035071. Epub 2010 Jun
      27.


PMID- 20581353
OWN - NLM
STAT- MEDLINE
DCOM- 20100813
LR  - 20151119
IS  - 1544-0591 (Electronic)
IS  - 0022-0345 (Linking)
VI  - 89
IP  - 8
DP  - 2010 Aug
TI  - Design, operation, and interpretation of clinical trials.
PG  - 759-72
LID - 10.1177/0022034510374737 [doi]
AB  - Randomized controlled clinical trials offer the best evidence for changing
      clinical practice and informing public health policy. Using examples from the
      literature, this paper reviews clinical trials for those who may be unfamiliar
      with their design, operation, and interpretation. In the design of a clinical
      trial, the question to be answered and a clinically meaningful outcome must be
      clearly defined. Ethics must be considered, sample size carefully estimated, and 
      use of biomarkers and surrogate outcomes understood. Prominent issues in trial
      implementation include developing a manual of operations, trial registration,
      subject recruitment and retention, use of a data coordinating center, and data
      and safety monitoring. Interpretation of clinical trials requires understanding
      differences between efficacy and effectiveness; superiority, equivalence, and
      non-inferiority; intent-to-treat; primary and secondary analyses; and limitations
      of unregistered small clinical trials compared with large multi-center Phase III 
      trials that are more likely to be representative of a population and change
      clinical practice or public health policy.
FAU - Pihlstrom, B L
AU  - Pihlstrom BL
AD  - School of Dentistry, University of Minnesota and Independent Oral Health Research
      Consultant, Bethesda, MD 20814, USA. bpihls@umn.edu
FAU - Barnett, M L
AU  - Barnett ML
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100625
PL  - United States
TA  - J Dent Res
JT  - Journal of dental research
JID - 0354343
RN  - 0 (Biomarkers)
SB  - IM
MH  - Biomarkers
MH  - Clinical Trials as Topic/*methods/*standards
MH  - Data Interpretation, Statistical
MH  - Dental Research/*methods
MH  - Humans
MH  - Multicenter Studies as Topic
MH  - *Research Design
MH  - Sample Size
MH  - Treatment Outcome
RF  - 102
EDAT- 2010/06/29 06:00
MHDA- 2010/08/14 06:00
CRDT- 2010/06/29 06:00
PHST- 2010/06/29 06:00 [entrez]
PHST- 2010/06/29 06:00 [pubmed]
PHST- 2010/08/14 06:00 [medline]
AID - 0022034510374737 [pii]
AID - 10.1177/0022034510374737 [doi]
PST - ppublish
SO  - J Dent Res. 2010 Aug;89(8):759-72. doi: 10.1177/0022034510374737. Epub 2010 Jun
      25.


PMID- 20580142
OWN - NLM
STAT- MEDLINE
DCOM- 20100831
LR  - 20220309
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 71
IP  - 4
DP  - 2010 Aug
TI  - Ethical challenges in the provision of end-of-life care in Norwegian nursing
      homes.
PG  - 677-84
LID - 10.1016/j.socscimed.2010.03.059 [doi]
AB  - As in other Western countries, most Norwegian nursing home patients are suffering
      from multi-pathological conditions and a large majority of them will die in the
      nursing home. End-of-life care represents many challenges, and it is a widespread
      concern that several nursing homes lack both resources and competence to ensure
      good quality care. This article examines the types and prevalence of ethical
      challenges in end-of-life care as nursing home staff consider them, as well as
      what they believe can help them to better cope with the ethical challenges. It is
      based on a national survey probing Norwegian nursing homes' end-of-life care at
      the ward level conducted in 2007. 664 respondents from 364 nursing homes answered
      the questionnaire, representing 68% of the patients and 76% of the nursing home
      sample. Inadequate care due to lack of resources and breaches of the patient's
      autonomy and integrity were the ethical challenges reported most often. Conflicts
      with the next of kin regarding nursing care and termination of life-prolonging
      treatment were reported more seldom. However, when asking the respondents to
      outline one of the most recent ethical dilemmas they had encountered, the
      majority of the respondents described ethical dilemmas concerning limitation of
      life-prolonging treatment, often mixed with disagreements between the wish of the
      family and that of the patient, or between the wish of the next of kin and what
      the staff consider to be right. Ethical dilemmas associated with breaches of the 
      patient's autonomy and integrity were also thoroughly described. According to the
      staff, better ethical knowledge along with more time to reflect on ethical
      dilemmas were the initiatives most desired to improve the staff's way of handling
      ethical challenges. Furthermore, to have an opportunity to consult with a person 
      holding ethical competence was emphasised by more than half of the respondents.
CI  - (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Gjerberg, Elisabeth
AU  - Gjerberg E
AD  - Norwegian Knowledge Centre for the Health Services/Section for Medical Ethics,
      University of Oslo, Oslo, Norway. elisabeth.gjerberg@medisin.uio.no
FAU - Forde, Reidun
AU  - Forde R
FAU - Pedersen, Reidar
AU  - Pedersen R
FAU - Bollig, Georg
AU  - Bollig G
LA  - eng
PT  - Journal Article
DEP - 20100526
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Adaptation, Psychological
MH  - Aged, 80 and over
MH  - *Attitude of Health Personnel
MH  - Female
MH  - Health Resources/ethics/supply & distribution
MH  - Homes for the Aged/*ethics/organization & administration
MH  - Humans
MH  - Interprofessional Relations/ethics
MH  - Male
MH  - Norway
MH  - Nursing Homes/*ethics/organization & administration
MH  - Nursing Staff/*psychology
MH  - Personal Autonomy
MH  - Professional-Family Relations/ethics
MH  - Quality of Health Care
MH  - Surveys and Questionnaires
MH  - Terminal Care/*ethics
MH  - Withholding Treatment/ethics
EDAT- 2010/06/29 06:00
MHDA- 2010/09/02 06:00
CRDT- 2010/06/29 06:00
PHST- 2009/03/17 00:00 [received]
PHST- 2010/03/17 00:00 [revised]
PHST- 2010/03/22 00:00 [accepted]
PHST- 2010/06/29 06:00 [entrez]
PHST- 2010/06/29 06:00 [pubmed]
PHST- 2010/09/02 06:00 [medline]
AID - S0277-9536(10)00396-5 [pii]
AID - 10.1016/j.socscimed.2010.03.059 [doi]
PST - ppublish
SO  - Soc Sci Med. 2010 Aug;71(4):677-84. doi: 10.1016/j.socscimed.2010.03.059. Epub
      2010 May 26.


PMID- 20580065
OWN - NLM
STAT- MEDLINE
DCOM- 20101210
LR  - 20151119
IS  - 1879-3231 (Electronic)
IS  - 0093-691X (Linking)
VI  - 74
IP  - 4
DP  - 2010 Sep 1
TI  - Characterization, isolation and culture of primordial germ cells in domestic
      animals: recent progress and insights from the ovine species.
PG  - 534-43
LID - 10.1016/j.theriogenology.2010.05.011 [doi]
AB  - Primordial germ cell (PGC) allocation, characterization, lineage restriction, and
      differentiation have been extensively studied in the mouse. Murine PGC can be
      easily identified using markers as alkaline phosphatase content or the expression
      of pluripotent markers such as Pou5f1, Nanog, Sox2, Kit, SSEA1, and SSEA4. These 
      tools allowed us to clarify certain aspects of the complex interactions of
      somatic and germinal cells in the establishment of the germ cell lineage, its
      segregation from the neighbouring somatic tissue, and the guidance mechanisms
      during migration that direct most of the germ cells into the genital ridges. Few 
      data are available from other domestic animals and here we reported our
      preliminary studies on the isolation, characterization, and in vitro culture of
      sheep PGCs. Sheep PGCs can be identified with the markers previously used in
      mouse, but, in some cases, these markers are not coherently expressed in the same
      cell depending on the grade of differentiation and on technical problems related 
      to commercial antibodies used. Pluripotency of PGCs in culture (EGCs) from
      domestic animals also needs further evaluation even though the derivation of
      embryonic pluripotent cell lines from large mammals may be an advantage as they
      are more physiologically similar to the human and perhaps more relevant for
      clinical translation studies. Comprehensive epigenetic reprogramming of the
      genome in early germ cells, and derived EGCs including extensive erasure of
      epigenetic modifications, may be relevant for gaining insight into events that
      lead to reprogramming and establishment of totipotency. EGCs can differentiate in
      vitro in a various range of tissues, form embryonic bodies, but in many cases
      failed to generate tumours when transplanted into immunodeficient mice and are
      not able to generate germline chimeric animals after their transfer. Such
      incomplete information clearly indicates the urge to improve the studies on
      derivation of stem cells in farm animals and shows the need for a
      multidisciplinary investigation in order to create farm animal models to set up
      suitable ethical and technical systems for cell regenerative therapies in humans.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Ledda, S
AU  - Ledda S
AD  - Department of Veterinary Clinics and Pathology, University of Sassari, Sassari,
      Italy. giodi@uniss.it
FAU - Bogliolo, L
AU  - Bogliolo L
FAU - Bebbere, D
AU  - Bebbere D
FAU - Ariu, F
AU  - Ariu F
FAU - Pirino, S
AU  - Pirino S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100626
PL  - United States
TA  - Theriogenology
JT  - Theriogenology
JID - 0421510
RN  - 0 (Biomarkers)
SB  - IM
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Cell Culture Techniques
MH  - Cell Differentiation
MH  - Cell Lineage
MH  - Embryo, Mammalian/cytology
MH  - Epigenesis, Genetic
MH  - Germ Cells/*cytology/metabolism
MH  - Mice
MH  - Pluripotent Stem Cells/*cytology/metabolism
MH  - Sheep/*embryology
MH  - Sus scrofa/embryology
EDAT- 2010/06/29 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/06/29 06:00
PHST- 2010/03/10 00:00 [received]
PHST- 2010/05/06 00:00 [revised]
PHST- 2010/05/06 00:00 [accepted]
PHST- 2010/06/29 06:00 [entrez]
PHST- 2010/06/29 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S0093-691X(10)00265-7 [pii]
AID - 10.1016/j.theriogenology.2010.05.011 [doi]
PST - ppublish
SO  - Theriogenology. 2010 Sep 1;74(4):534-43. doi:
      10.1016/j.theriogenology.2010.05.011. Epub 2010 Jun 26.


PMID- 20579281
OWN - NLM
STAT- MEDLINE
DCOM- 20100712
LR  - 20211020
IS  - 1468-0009 (Electronic)
IS  - 0887-378X (Linking)
VI  - 88
IP  - 2
DP  - 2010 Jun
TI  - Where is the future in public health?
PG  - 149-68
LID - 10.1111/j.1468-0009.2010.00594.x [doi]
AB  - CONTEXT: Today's societies have far-reaching impacts on future conditions for
      health. Against this backdrop, this article explores how the future is
      represented in contemporary public health, examining both its conceptual base and
      influential approaches through which evidence is generated for policy. METHODS:
      Mission statements and official reviews provide insight into how the future is
      represented in public health's conceptual and ethical foundations. For its
      research practices, the article takes examples from epidemiological,
      intervention, and economic research, selecting risk-factor epidemiology,
      randomized controlled trials, and economic evaluation as exemplars. FINDINGS:
      Concepts and ethics suggest that public health research and policy will be
      concerned with protecting both today's and tomorrow's populations from conditions
      that threaten their health. But rather than facilitating sustained engagement
      with future conditions and future health, exemplary approaches to gathering
      evidence focus on today's population. Thus, risk-factor epidemiology pinpoints
      risks in temporal proximity to the individual; controlled trials track short-term
      effects of interventions on the participants' health; and economic evaluations
      weigh policies according to their value to the current population. While their
      orientation to the present and near future aligns well with the compressed
      timescales for policy delivery on which democratic governments tend to work, it
      makes it difficult for the public health community to direct attention to
      conditions for future health. CONCLUSIONS: This article points to the need for
      research perspectives and practices that, consistent with public health's
      conceptual and ethical foundations, represent the interests of both tomorrow's
      and today's populations.
FAU - Graham, Hilary
AU  - Graham H
AD  - University of York, York, UK. hmg501@york.ac.uk
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Milbank Q
JT  - The Milbank quarterly
JID - 8607003
SB  - IM
MH  - Biomedical Research/trends
MH  - Epidemiology/organization & administration/trends
MH  - Forecasting
MH  - Health Policy/economics/trends
MH  - Health Services Research/trends
MH  - Humans
MH  - Policy Making
MH  - Public Health/ethics/*trends
MH  - Public Health Administration/trends
PMC - PMC2980342
EDAT- 2010/06/29 06:00
MHDA- 2010/07/14 06:00
CRDT- 2010/06/29 06:00
PHST- 2010/06/29 06:00 [entrez]
PHST- 2010/06/29 06:00 [pubmed]
PHST- 2010/07/14 06:00 [medline]
AID - MILQ594 [pii]
AID - 10.1111/j.1468-0009.2010.00594.x [doi]
PST - ppublish
SO  - Milbank Q. 2010 Jun;88(2):149-68. doi: 10.1111/j.1468-0009.2010.00594.x.


PMID- 20579255
OWN - NLM
STAT- MEDLINE
DCOM- 20101122
LR  - 20220408
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 38
IP  - 2
DP  - 2010 Summer
TI  - Stem cell research as innovation: expanding the ethical and policy conversation.
PG  - 332-41
LID - 10.1111/j.1748-720X.2010.00492.x [doi]
AB  - Research using human embryonic stem cells raises an array of complex ethical
      issues, including, but by no means limited to, the moral status of developing
      human life. Unfortunately much of the public discussion fails to take into
      account this complexity. Advocacy for liberal and conservative positions on human
      embryonic stem cell research can be simplistic and misleading. Ethical concepts
      such as truth-telling, scientific integrity, and social justice should be part of
      the debate over federal support for human embryonic stem cell research. Moreover,
      the debate should be conducted in accord with principles of deliberative
      democracy, including respect for people holding competing views.
FAU - Dresser, Rebecca
AU  - Dresser R
AD  - Washington University, St. Louis, USA.
LA  - eng
GR  - UL1 RR024992/RR/NCRR NIH HHS/United States
GR  - UL1 RR024992-01/RR/NCRR NIH HHS/United States
GR  - UL1 TR000448/TR/NCATS NIH HHS/United States
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Attitude to Health
MH  - *Diffusion of Innovation
MH  - *Dissent and Disputes
MH  - Embryo Research/*ethics
MH  - *Embryonic Stem Cells
MH  - *Health Policy
MH  - Health Priorities/ethics
MH  - Health Services Needs and Demand/ethics
MH  - Humans
MH  - Lobbying
MH  - National Institutes of Health (U.S.)/ethics
MH  - Research Support as Topic/ethics
MH  - Resource Allocation/ethics
MH  - Science/ethics
MH  - Social Justice/ethics
MH  - Social Responsibility
MH  - Therapeutic Misconception/ethics
MH  - Truth Disclosure
MH  - United States
PMC - PMC2941662
MID - NIHMS221591
EDAT- 2010/06/29 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/06/29 06:00
PHST- 2010/06/29 06:00 [entrez]
PHST- 2010/06/29 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - JLME492 [pii]
AID - 10.1111/j.1748-720X.2010.00492.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2010 Summer;38(2):332-41. doi:
      10.1111/j.1748-720X.2010.00492.x.


PMID- 20579251
OWN - NLM
STAT- MEDLINE
DCOM- 20101122
LR  - 20220410
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 38
IP  - 2
DP  - 2010 Summer
TI  - Allowing innovative stem cell-based therapies outside of clinical trials: ethical
      and policy challenges.
PG  - 277-85
LID - 10.1111/j.1748-720X.2010.00488.x [doi]
AB  - This paper discusses exceptional circumstances under which patients outside of
      clinical trials are likely to receive innovative stem cell-based interventions.
      These circumstances involve: (1) stem cell interventions not initially amenable
      to a clinical trials approach; (2) expanded access to investigational stem cell
      products ("compassionate use"); and (3) off-label uses of FDA approved stem cell 
      products. This paper proposes a new approach to regulating these exceptional
      cases.
FAU - Hyun, Insoo
AU  - Hyun I
AD  - Department of Bioethics, Case Western Reserve University School of Medicine,
      Cleveland, Ohio, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Clinical Trials as Topic/*ethics/legislation & jurisprudence
MH  - Compassionate Use Trials/*ethics/legislation & jurisprudence
MH  - *Diffusion of Innovation
MH  - Ethical Analysis
MH  - Federal Government
MH  - Government Regulation
MH  - Guidelines as Topic
MH  - *Health Policy/legislation & jurisprudence
MH  - Health Services Accessibility/ethics/legislation & jurisprudence
MH  - Humans
MH  - Medical Tourism/ethics/psychology/statistics & numerical data
MH  - Off-Label Use/*ethics/legislation & jurisprudence
MH  - Regenerative Medicine/ethics/legislation & jurisprudence
MH  - Stem Cell Transplantation/*ethics/legislation & jurisprudence
MH  - Translational Research, Biomedical/ethics/legislation & jurisprudence
MH  - United States
MH  - United States Food and Drug Administration
EDAT- 2010/06/29 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/06/29 06:00
PHST- 2010/06/29 06:00 [entrez]
PHST- 2010/06/29 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - JLME488 [pii]
AID - 10.1111/j.1748-720X.2010.00488.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2010 Summer;38(2):277-85. doi:
      10.1111/j.1748-720X.2010.00488.x.


PMID- 20579250
OWN - NLM
STAT- MEDLINE
DCOM- 20101122
LR  - 20211203
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 38
IP  - 2
DP  - 2010 Summer
TI  - Translating stem cell research: challenges at the research frontier.
PG  - 267-76
LID - 10.1111/j.1748-720X.2010.00487.x [doi]
AB  - This paper will address the translation of basic stem cell research into clinical
      research. While "stem cell" trials are sometimes used to describe established
      practices of bone marrow transplantation or transplantation of primary cells
      derived from bone marrow, for the purposes of this paper, I am primarily focusing
      on stem cell trials which are far less established, including use of hESC derived
      stem cells. The central ethical challenges in stem cell clinical trials arise in 
      frontier research, not in standard, well-established areas of research.
FAU - Magnus, David
AU  - Magnus D
AD  - Stanford University, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Animals
MH  - Clinical Trials as Topic/classification/*ethics/legislation & jurisprudence
MH  - Diffusion of Innovation
MH  - Disease Models, Animal
MH  - Embryonic Stem Cells
MH  - Gene Transfer Techniques/ethics
MH  - Government Regulation
MH  - Guidelines as Topic
MH  - Humans
MH  - Informed Consent/ethics/legislation & jurisprudence
MH  - Research Design
MH  - Research Embryo Creation/*ethics/legislation & jurisprudence
MH  - Safety
MH  - Social Justice/ethics
MH  - Stem Cell Transplantation/*ethics/legislation & jurisprudence
MH  - Therapeutic Misconception/ethics
MH  - Translational Research, Biomedical/*ethics/organization & administration
MH  - United States
MH  - United States Food and Drug Administration
EDAT- 2010/06/29 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/06/29 06:00
PHST- 2010/06/29 06:00 [entrez]
PHST- 2010/06/29 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - JLME487 [pii]
AID - 10.1111/j.1748-720X.2010.00487.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2010 Summer;38(2):267-76. doi:
      10.1111/j.1748-720X.2010.00487.x.


PMID- 20579249
OWN - NLM
STAT- MEDLINE
DCOM- 20101122
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 38
IP  - 2
DP  - 2010 Summer
TI  - Resolving ethical issues in stem cell clinical trials: the example of Parkinson
      disease.
PG  - 257-66
LID - 10.1111/j.1748-720X.2010.00486.x [doi]
AB  - Clinical trials of stem cell transplantation raise ethical issues that are
      intertwined with scientific and design issues, including choice of control group 
      and intervention, background interventions, endpoints, and selection of subjects.
      We recommend that the review and IRB oversight of stem cell clinical trials
      should be strengthened. Scientific and ethics review should be integrated in
      order to better assess risks and potential benefits. Informed consent should be
      enhanced by assuring that participants comprehend key aspects of the trial. For
      the trial to yield generalizable knowledge, negative findings and serious adverse
      events must be reported.
FAU - Lo, Bernard
AU  - Lo B
AD  - UCSF, USA.
FAU - Parham, Lindsay
AU  - Parham L
LA  - eng
GR  - 1 UL1 RR024131-01/RR/NCRR NIH HHS/United States
GR  - MH062246/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
RN  - 0 (Placebos)
MH  - Clinical Trials as Topic/*ethics/legislation & jurisprudence
MH  - Ethical Analysis
MH  - Ethical Review/legislation & jurisprudence
MH  - Federal Government
MH  - Government Regulation
MH  - Humans
MH  - Parkinson Disease/*therapy
MH  - Patient Advocacy/*ethics/legislation & jurisprudence
MH  - Patient Selection/*ethics
MH  - Placebos
MH  - Research Design
MH  - Safety
MH  - Stem Cell Transplantation/*ethics/legislation & jurisprudence
MH  - United States
MH  - United States Food and Drug Administration
EDAT- 2010/06/29 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/06/29 06:00
PHST- 2010/06/29 06:00 [entrez]
PHST- 2010/06/29 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - JLME486 [pii]
AID - 10.1111/j.1748-720X.2010.00486.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2010 Summer;38(2):257-66. doi:
      10.1111/j.1748-720X.2010.00486.x.


PMID- 20579248
OWN - NLM
STAT- MEDLINE
DCOM- 20101122
LR  - 20211203
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 38
IP  - 2
DP  - 2010 Summer
TI  - Reflections on governance models for the clinical translation of stem cells.
PG  - 251-6
LID - 10.1111/j.1748-720X.2010.00485.x [doi]
AB  - Governance models for the oversight of human embryonic stem cell research have
      been proposed which mirror in large part familiar oversight mechanisms for
      research with human subjects and non-human animals. While such models are in
      principle readily endorsable, there are a set of concerns related to their
      implementation--such as ensuring that an elaborated informed consent process and 
      conducting long-term monitoring of research subjects are tenable--which suggest
      areas where gathering data may facilitate more appropriate oversight. In
      addition, it is unclear whether a new governance model based at individual
      institutions are sufficient to address the ethical issues inherent to this
      research. Regardless, some of the concerns that have arisen in considering the
      appropriate governance of stem cell research, particularly the important
      translational pathway of innovation in contrast to staged research, transparency 
      and publication, and social justice, may be useful in science and translational
      research more broadly.
FAU - Sugarman, Jeremy
AU  - Sugarman J
AD  - Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Advisory Committees/organization & administration
MH  - Clinical Governance
MH  - Decision Making, Organizational
MH  - Diffusion of Innovation
MH  - *Embryo Research/ethics/legislation & jurisprudence
MH  - Embryonic Stem Cells
MH  - Federal Government
MH  - *Government Regulation
MH  - *Guidelines as Topic
MH  - Humans
MH  - Informed Consent/ethics/legislation & jurisprudence
MH  - *Models, Organizational
MH  - National Academy of Sciences, U.S./organization & administration
MH  - Science/ethics/organization & administration
MH  - Social Justice/ethics/legislation & jurisprudence
MH  - Societies, Scientific/organization & administration
MH  - *Translational Research, Biomedical/ethics/organization & administration
MH  - Truth Disclosure/ethics
MH  - United States
EDAT- 2010/06/29 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/06/29 06:00
PHST- 2010/06/29 06:00 [entrez]
PHST- 2010/06/29 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - JLME485 [pii]
AID - 10.1111/j.1748-720X.2010.00485.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2010 Summer;38(2):251-6. doi: 10.1111/j.1748-720X.2010.00485.x.


PMID- 20579247
OWN - NLM
STAT- MEDLINE
DCOM- 20101122
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 38
IP  - 2
DP  - 2010 Summer
TI  - Chimeras, moral status, and public policy: implications of the abortion debate
      for public policy on human/nonhuman chimera research.
PG  - 238-50
LID - 10.1111/j.1748-720X.2010.00484.x [doi]
AB  - Researchers are increasingly interested in creating chimeras by transplanting
      human embryonic stem cells (hESCs) into animals early in development. One concern
      is that such research could confer upon an animal the moral status of a normal
      human adult but then impermissibly fail to accord it the protections it merits in
      virtue of its enhanced moral status. Understanding the public policy implications
      of this ethical conclusion, though, is complicated by the fact that claims about 
      moral status cannot play an unfettered role in public policy. Arguments like
      those employed in the abortion debate for the conclusion that abortion should be 
      legally permissible even if abortion is not morally permissible also support, to 
      a more limited degree, a liberal policy on hESC research involving the creation
      of chimeras.
FAU - Streiffer, Robert
AU  - Streiffer R
AD  - University of Wisconsin-Madison, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Abortion, Induced/*ethics/legislation & jurisprudence
MH  - Animal Rights/legislation & jurisprudence
MH  - Animals
MH  - Beginning of Human Life/ethics
MH  - *Chimera
MH  - *Dissent and Disputes
MH  - Embryo Research/*ethics/legislation & jurisprudence
MH  - Embryonic Stem Cells
MH  - Government Regulation
MH  - *Health Policy/legislation & jurisprudence
MH  - Human Rights/legislation & jurisprudence
MH  - Humans
MH  - *Morals
MH  - Personhood
MH  - Research Support as Topic/ethics/legislation & jurisprudence
MH  - United States
EDAT- 2010/06/29 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/06/29 06:00
PHST- 2010/06/29 06:00 [entrez]
PHST- 2010/06/29 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - JLME484 [pii]
AID - 10.1111/j.1748-720X.2010.00484.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2010 Summer;38(2):238-50. doi:
      10.1111/j.1748-720X.2010.00484.x.


PMID- 20579246
OWN - NLM
STAT- MEDLINE
DCOM- 20101122
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 38
IP  - 2
DP  - 2010 Summer
TI  - Creating embryos for use in stem cell research.
PG  - 229-37
LID - 10.1111/j.1748-720X.2010.00483.x [doi]
AB  - In this paper I will address whether the restriction on the creation of human
      embryos solely for the purpose of research in which they will be used and
      destroyed in the creation of human stem cell lines is ethically justified. Of
      course, a cynical but perhaps accurate reading of the new Obama policy is that
      leaving this restriction in place was done for political, not ethical, reasons,
      in light of the apparent public opposition to creating embryos for use in this
      research. But the issue of whether the restriction is ethically justified remains
      important, even if only for another day in the policy arena.
FAU - Brock, Dan W
AU  - Brock DW
AD  - Division of Medical Ethics, Harvard Medical School, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Beginning of Human Life/*ethics
MH  - *Dissent and Disputes
MH  - *Embryonic Stem Cells
MH  - Federal Government
MH  - Fertilization in Vitro
MH  - Government Regulation
MH  - Humans
MH  - Intention
MH  - Morals
MH  - *Personhood
MH  - Politics
MH  - Research Embryo Creation/*ethics/legislation & jurisprudence
MH  - Research Support as Topic/ethics/legislation & jurisprudence
MH  - United States
MH  - Wedge Argument
EDAT- 2010/06/29 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/06/29 06:00
PHST- 2010/06/29 06:00 [entrez]
PHST- 2010/06/29 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - JLME483 [pii]
AID - 10.1111/j.1748-720X.2010.00483.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2010 Summer;38(2):229-37. doi:
      10.1111/j.1748-720X.2010.00483.x.


PMID- 20579245
OWN - NLM
STAT- MEDLINE
DCOM- 20101122
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 38
IP  - 2
DP  - 2010 Summer
TI  - Political interventions in U.S. human embryo research: an ethical assessment.
PG  - 220-8
LID - 10.1111/j.1748-720X.2010.00482.x [doi]
AB  - For more than 30 years, beginning with the Reagan administration's refusal to
      support and provide oversight for embryo research, and continuing to the present 
      in congressionally imposed limits on funding for such research, progress in
      infertility medicine and the development of stem cell therapies has been
      seriously delayed by a series of political interventions. In almost all cases,
      these interventions result from a view of the moral status of human embryo
      premised largely on religious assumptions. Although some believe that these
      interventions are valid expressions of religious values in the public sector, it 
      is argued here that they, in fact, contradict Rawls's conception of public
      reasoning. Both the prohibition of research involving the human embryo as well as
      bans on federal funding for embryo-related research place the particular
      religious views of some citizens above the pressing health needs of almost all,
      and thus violate the ideal of civility implicit in the Rawlsian standard.
FAU - Green, Ronald M
AU  - Green RM
AD  - Religion Department, Dartmouth College, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Advisory Committees/ethics
MH  - *Dissent and Disputes
MH  - Embryo Research/*ethics/legislation & jurisprudence
MH  - *Ethical Analysis
MH  - Federal Government
MH  - Government Regulation
MH  - *Health Policy/legislation & jurisprudence/trends
MH  - Humans
MH  - *Politics
MH  - Religion and Science
MH  - Research Support as Topic/*ethics/legislation & jurisprudence
MH  - Science/ethics/legislation & jurisprudence
MH  - United States
EDAT- 2010/06/29 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/06/29 06:00
PHST- 2010/06/29 06:00 [entrez]
PHST- 2010/06/29 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - JLME482 [pii]
AID - 10.1111/j.1748-720X.2010.00482.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2010 Summer;38(2):220-8. doi: 10.1111/j.1748-720X.2010.00482.x.


PMID- 20579244
OWN - NLM
STAT- MEDLINE
DCOM- 20101122
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 38
IP  - 2
DP  - 2010 Summer
TI  - Old and new ethics in the stem cell debate.
PG  - 212-9
LID - 10.1111/j.1748-720X.2010.00481.x [doi]
AB  - The debate about embryonic stem cell research is a conflict not between
      "religion" and "science," but between two ethical approaches to the dignity of
      human beings. The newer, more pragmatic ethic is not necessarily more conducive
      to rapid medical progress as is often assumed.
FAU - Doerflinger, Richard M
AU  - Doerflinger RM
AD  - National Catholic Bioethics Center, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Beginning of Human Life/ethics
MH  - Diffusion of Innovation
MH  - *Dissent and Disputes
MH  - Embryo Research/*ethics
MH  - *Embryonic Stem Cells
MH  - Ethical Theory
MH  - *Human Rights
MH  - Humans
MH  - Morals
MH  - *Personhood
MH  - Politics
MH  - Religion and Science
MH  - United States
MH  - Value of Life
EDAT- 2010/06/29 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/06/29 06:00
PHST- 2010/06/29 06:00 [entrez]
PHST- 2010/06/29 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - JLME481 [pii]
AID - 10.1111/j.1748-720X.2010.00481.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2010 Summer;38(2):212-9. doi: 10.1111/j.1748-720X.2010.00481.x.


PMID- 20579243
OWN - NLM
STAT- MEDLINE
DCOM- 20101122
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 38
IP  - 2
DP  - 2010 Summer
TI  - Why scientific details are important when novel technologies encounter law,
      politics, and ethics.
PG  - 204-11
LID - 10.1111/j.1748-720X.2010.00480.x [doi]
AB  - This paper focuses on the issue of what to do if a couple who generates embryos
      chooses to lawfully, and in their (and my) view, ethnically discard those
      embryos. Specifically, is it appropriate to use the cells that come from "excess"
      embryos in medical research instead of discarding them when a couple has ceased
      trying to have any additional children?
FAU - Goldstein, Lawrence
AU  - Goldstein L
AD  - University of California, San Diego, School of Medicine, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Alzheimer Disease/genetics/therapy
MH  - *Biological Science Disciplines/ethics/legislation & jurisprudence
MH  - *Dissent and Disputes
MH  - *Embryo Research/ethics/legislation & jurisprudence
MH  - *Embryonic Stem Cells
MH  - Fertilization in Vitro/ethics/legislation & jurisprudence
MH  - Human Experimentation/ethics/legislation & jurisprudence
MH  - Humans
MH  - *Politics
MH  - Safety/legislation & jurisprudence
MH  - Technology Assessment, Biomedical/ethics/legislation & jurisprudence
MH  - United States
EDAT- 2010/06/29 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/06/29 06:00
PHST- 2010/06/29 06:00 [entrez]
PHST- 2010/06/29 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - JLME480 [pii]
AID - 10.1111/j.1748-720X.2010.00480.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2010 Summer;38(2):204-11. doi:
      10.1111/j.1748-720X.2010.00480.x.


PMID- 20579237
OWN - NLM
STAT- MEDLINE
DCOM- 20101122
LR  - 20211020
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 38
IP  - 2
DP  - 2010 Summer
TI  - Currents in contemporary ethics. Should health care providers get treatment
      priority in an influenza pandemic?
PG  - 412-9
LID - 10.1111/j.1748-720X.2010.00499.x [doi]
FAU - Rothstein, Mark A
AU  - Rothstein MA
AD  - Institute for Bioethics, Health Policy and Law, University of Louisville School
      of Medicine, Kentucky, USA. mark.rothstein@louisville.edu
LA  - eng
GR  - P30 ES014443/ES/NIEHS NIH HHS/United States
GR  - P30 ES014443-04/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Codes of Ethics
MH  - Ethical Analysis
MH  - Ethical Theory
MH  - Health Personnel/*ethics
MH  - Health Priorities/ethics
MH  - Health Services Accessibility/ethics
MH  - Humans
MH  - Influenza, Human/epidemiology/*therapy
MH  - Moral Obligations
MH  - Pandemics/*ethics/prevention & control
MH  - Patient Selection/*ethics
MH  - Principle-Based Ethics
MH  - Resource Allocation/*ethics
MH  - Social Justice
MH  - Social Values
MH  - United States/epidemiology
PMC - PMC3033763
MID - NIHMS264886
EDAT- 2010/06/29 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/06/29 06:00
PHST- 2010/06/29 06:00 [entrez]
PHST- 2010/06/29 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - JLME499 [pii]
AID - 10.1111/j.1748-720X.2010.00499.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2010 Summer;38(2):412-9. doi: 10.1111/j.1748-720X.2010.00499.x.


PMID- 20579234
OWN - NLM
STAT- MEDLINE
DCOM- 20101122
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 38
IP  - 2
DP  - 2010 Summer
TI  - Diagnosing consciousness: neuroimaging, law, and the vegetative state.
PG  - 374-85
LID - 10.1111/j.1748-720X.2010.00496.x [doi]
AB  - In this paper, we review recent neuroimaging investigations of disorders of
      consciousness and different disciplines' understanding of consciousness itself.
      We consider potential tests of consciousness, their legal significance, and how
      they map onto broader themes in U.S. statutory law pertaining to advance
      directives and surrogate decision-making. In the process, we outline a taxonomy
      of themes to illustrate and clarify the variance in state-law definitions of
      consciousness. Finally, we discuss broader scientific, ethical, and legal issues 
      associated with the advent of neuroimaging for disorders of consciousness and
      conclude with policy recommendations that could help to mitigate confusion in
      this realm.
FAU - Fisher, Carl E
AU  - Fisher CE
AD  - Columbia University and the New York State Psychiatric Institute, New York, NY,
      USA.
FAU - Appelbaum, Paul S
AU  - Appelbaum PS
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Advance Care Planning/ethics/legislation & jurisprudence
MH  - *Brain Death/diagnosis/legislation & jurisprudence
MH  - Consciousness Disorders/classification/*diagnosis
MH  - Decision Making
MH  - *Diagnostic Imaging/ethics/methods
MH  - *Diagnostic Techniques, Neurological/ethics
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Persistent Vegetative State/*diagnosis
MH  - Positron-Emission Tomography
MH  - Proxy/legislation & jurisprudence
MH  - United States
EDAT- 2010/06/29 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/06/29 06:00
PHST- 2010/06/29 06:00 [entrez]
PHST- 2010/06/29 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - JLME496 [pii]
AID - 10.1111/j.1748-720X.2010.00496.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2010 Summer;38(2):374-85. doi:
      10.1111/j.1748-720X.2010.00496.x.


PMID- 20579117
OWN - NLM
STAT- MEDLINE
DCOM- 20110328
LR  - 20211020
IS  - 1369-7625 (Electronic)
IS  - 1369-6513 (Linking)
VI  - 13
IP  - 4
DP  - 2010 Dec
TI  - 'Never heard of it'- understanding the public's lack of awareness of a new
      electronic patient record.
PG  - 379-91
LID - 10.1111/j.1369-7625.2010.00608.x [doi]
AB  - BACKGROUND: The introduction of electronic patient records that are accessible by
      multiple providers raises security issues and requires informed consent - or at
      the very least, an opportunity to opt out. Introduction of the Summary Care
      Record (SCR) (a centrally stored electronic summary of a patient's medical
      record) in pilot sites in the UK was associated with low awareness, despite an
      intensive public information programme that included letters, posters, leaflets, 
      and road shows. AIM: To understand why the public information programme had
      limited impact and to learn lessons for future programmes. METHODS: Linguistic
      and communications analysis of components of the programme, contextualized within
      a wider mixed-method case study of the introduction of the SCR in pilot sites.
      Theoretical insights from linguistics and communication studies were applied.
      RESULTS: The context of the SCR pilots and the linked information programme
      created inherent challenges which were partially but not fully overcome by the
      efforts of campaigners. Much effort was put into designing the content of a mail 
      merge letter, but less attention was given to its novelty, linguistic style, and 
      rhetorical appeal. Many recipients viewed this letter as junk mail or propaganda 
      and discarded it unread. Other components of the information programme were
      characterized by low visibility, partly because only restricted areas were
      participating in the pilot. Relatively little use was made of interpersonal
      communication channels. CONCLUSION: Despite ethical and legal imperatives,
      informed consent for the introduction of shared electronic records may be
      difficult to achieve through public information campaigns. Success may be more
      likely if established principles of effective mass and interpersonal
      communication are applied.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Bratan, Tanja
AU  - Bratan T
AD  - Research Department of Open Learning, Division of Medical Education, University
      College London, London, UK. t.bratan@ucl.ac.uk
FAU - Stramer, Katja
AU  - Stramer K
FAU - Greenhalgh, Trisha
AU  - Greenhalgh T
LA  - eng
GR  - G0600654/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PL  - England
TA  - Health Expect
JT  - Health expectations : an international journal of public participation in health 
      care and health policy
JID - 9815926
SB  - IM
MH  - *Electronic Health Records
MH  - Health Knowledge, Attitudes, Practice
MH  - Health Literacy
MH  - Humans
MH  - *Information Dissemination
MH  - Informed Consent
MH  - Pilot Projects
MH  - Program Evaluation
MH  - *Public Opinion
MH  - United Kingdom
PMC - PMC5060545
EDAT- 2010/06/29 06:00
MHDA- 2011/03/29 06:00
CRDT- 2010/06/29 06:00
PHST- 2010/06/29 06:00 [entrez]
PHST- 2010/06/29 06:00 [pubmed]
PHST- 2011/03/29 06:00 [medline]
AID - HEX608 [pii]
AID - 10.1111/j.1369-7625.2010.00608.x [doi]
PST - ppublish
SO  - Health Expect. 2010 Dec;13(4):379-91. doi: 10.1111/j.1369-7625.2010.00608.x.


PMID- 20579054
OWN - NLM
STAT- MEDLINE
DCOM- 20101014
LR  - 20161125
IS  - 1468-4446 (Electronic)
IS  - 0007-1315 (Linking)
VI  - 61
IP  - 2
DP  - 2010 Jun
TI  - Making a difference: ethical consumption and the everyday.
PG  - 256-74
LID - 10.1111/j.1468-4446.2010.01312.x [doi]
AB  - Our everyday shopping practices are increasingly marketed as opportunities to
      'make a difference' via our ethical consumption choices. In response to a growing
      body of work detailing the ways in which specific alignments of 'ethics' and
      'consumption' are mediated, we explore how 'ethical' opportunities such as the
      consumption of Fairtrade products are recognized, experienced and taken-up in the
      everyday. The 'everyday' is approached here via a specially commissioned Mass
      Observation directive, a volunteer panel of correspondents in the UK. Our
      on-going thematic analysis of their autobiographical accounts aims to explore a
      complex unevenness in the ways 'ordinary' people experience and negotiate calls
      to enact their ethical agency through consumption. Situating ethical consumption,
      moral obligation and choice in the everyday is, we argue, important if we are to 
      avoid both over-exaggerating the reflexive and self-conscious sensibilities
      involved in ethical consumption, and, adhering to a reductive understanding of
      ethical self-expression.
FAU - Adams, Matthew
AU  - Adams M
AD  - School of Applied Social Science, University of Brighton. ma21@bton.ac.uk
FAU - Raisborough, Jayne
AU  - Raisborough J
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Sociol
JT  - The British journal of sociology
JID - 0373126
SB  - IM
MH  - Commerce/ethics
MH  - *Economics
MH  - *Ethics
MH  - Humans
MH  - Models, Theoretical
MH  - Social Responsibility
MH  - United Kingdom
EDAT- 2010/06/29 06:00
MHDA- 2010/10/15 06:00
CRDT- 2010/06/29 06:00
PHST- 2010/06/29 06:00 [entrez]
PHST- 2010/06/29 06:00 [pubmed]
PHST- 2010/10/15 06:00 [medline]
AID - BJOS1312 [pii]
AID - 10.1111/j.1468-4446.2010.01312.x [doi]
PST - ppublish
SO  - Br J Sociol. 2010 Jun;61(2):256-74. doi: 10.1111/j.1468-4446.2010.01312.x.


PMID- 20578601
OWN - NLM
STAT- MEDLINE
DCOM- 20100809
LR  - 20131121
IS  - 0030-9982 (Print)
IS  - 0030-9982 (Linking)
VI  - 60
IP  - 7
DP  - 2010 Jul
TI  - Patient satisfaction of depot medroxyprogesterone acetate (dmpa-sc) injection as 
      contraceptive.
PG  - 536-40
AB  - OBJECTIVE: To determine Patient Satisfaction of DMPA-SC (104 mg/0.65 mL) injected
      subcutaneously once every 3 months. METHODS: It was a Descriptive case series
      with the centre in Rawalpindi (Holy Family Hospital, Gynecology and Obstetrics
      Unit), Pakistan. Twenty five patients were selected by purposive sampling and
      followed up in Rawalpindi center (Holy Family Hospital, Gynaecology and Obstetric
      Unit) for one year as a part of the Asian Trial These patients had successfully
      completed their contraception using DMPA-sc at 3 months interval. Hospital
      Ethical Committee Permission was obtained prior to commencement of study.
      Informed written consent was taken from the patients. Body weight was measured at
      baseline and every 3 months thereafter. Bleeding analysis was also done at 3
      months interval using a 5 point scale based on patient's own records. Participant
      satisfaction with treatment results was evaluated using a patient satisfaction
      questionnaire (PSQ). It collected data regarding the respondent's experience with
      the study, the aspects of treatment that were liked and disliked and the
      likelihood of selecting that method for future contraceptive purposes. RESULTS:
      Out of twenty five, 15 (60%) patients had a high inclination Six (24%) patients
      and 9 (36%) very highly likely to use this contraceptive method in future. Eleven
      (44%) women replied that the probability of recommending this contraceptive
      method to their friends was very highly likely. CONCLUSIONS: DMPA-SC has a very
      high percentage score of Patient Satisfaction for the contraceptive method as
      well as its likelihood of selecting it in future (JPMA 60:536; 2010).
FAU - Chaudhri, Rizwana
AU  - Chaudhri R
AD  - Department of Gynecology and Obstetrics, Holy Family Hospital, Rawalpindi,
      Pakistan.
FAU - Rizvi, Farwa
AU  - Rizvi F
FAU - Afzal, Muhammad
AU  - Afzal M
LA  - eng
PT  - Journal Article
PL  - Pakistan
TA  - J Pak Med Assoc
JT  - JPMA. The Journal of the Pakistan Medical Association
JID - 7501162
RN  - 0 (Contraceptive Agents, Female)
RN  - 0 (Delayed-Action Preparations)
RN  - C2QI4IOI2G (Medroxyprogesterone Acetate)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Contraceptive Agents, Female/*administration & dosage
MH  - Delayed-Action Preparations
MH  - Female
MH  - Humans
MH  - Injections, Subcutaneous
MH  - Medroxyprogesterone Acetate/*administration & dosage
MH  - Middle Aged
MH  - *Patient Satisfaction
MH  - Young Adult
EDAT- 2010/06/29 06:00
MHDA- 2010/08/10 06:00
CRDT- 2010/06/29 06:00
PHST- 2010/06/29 06:00 [entrez]
PHST- 2010/06/29 06:00 [pubmed]
PHST- 2010/08/10 06:00 [medline]
AID - 2163 [pii]
PST - ppublish
SO  - J Pak Med Assoc. 2010 Jul;60(7):536-40.


PMID- 20578565
OWN - NLM
STAT- MEDLINE
DCOM- 20100716
LR  - 20100628
IS  - 0125-1562 (Print)
IS  - 0125-1562 (Linking)
VI  - 41
IP  - 3
DP  - 2010 May
TI  - A pilot use of team-based learning in graduate public health education.
PG  - 743-53
AB  - This pilot study was undertaken to determine the impact of team-based learning
      (TBL) on graduate students of public health in a Thai context. The pilot project 
      adopted Michaelsen's approach with the aim of improving learning among Thai
      graduate students enrolled in public health ethics. This TBL approach attempted
      to motivate students to do pre-class reading and be active "in-class" learners.
      Pre-class preparation allowed teachers to address and concentrate on learning
      gaps, while team work promoted peer interaction and active learning. TBL was
      found to be useful in fostering student preparedness and to transform "passive"
      into "active" learning, which especially benefited students "academically at
      risk" through peer teaching opportunities. With TBL, students valued the
      relevance of the course content and learning materials. They had positive
      opinions regarding the effect of TBL on individual and group learning. TBL was
      perceived to be instrumental in translating conceptual into applicable knowledge,
      and stimulated individual efforts as well as accountability. This study should be
      useful to those considering using TBL for public health education.
FAU - Van der Putten, Marc
AU  - Van der Putten M
AD  - Faculty of Public Health, Thammasat University, Rangsit Campus, Klong Luang,
      Paholyothin Road, Patum Thani 12121, Thailand. mvdp@tu.ac.th
FAU - Vichit-Vadakan, Nuntavarn
AU  - Vichit-Vadakan N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Thailand
TA  - Southeast Asian J Trop Med Public Health
JT  - The Southeast Asian journal of tropical medicine and public health
JID - 0266303
SB  - IM
MH  - Adult
MH  - *Education, Graduate
MH  - *Education, Public Health Professional
MH  - Female
MH  - *Group Processes
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Organizational Case Studies
MH  - Pilot Projects
MH  - Program Evaluation
MH  - Teaching/*methods
MH  - Thailand
EDAT- 2010/06/29 06:00
MHDA- 2010/07/17 06:00
CRDT- 2010/06/29 06:00
PHST- 2010/06/29 06:00 [entrez]
PHST- 2010/06/29 06:00 [pubmed]
PHST- 2010/07/17 06:00 [medline]
PST - ppublish
SO  - Southeast Asian J Trop Med Public Health. 2010 May;41(3):743-53.


PMID- 20578374
OWN - NLM
STAT- MEDLINE
DCOM- 20100706
LR  - 20190724
IS  - 0021-5384 (Print)
IS  - 0021-5384 (Linking)
VI  - 99
IP  - 4
DP  - 2010 Apr 10
TI  - [Basis of professionalism: implementation of postgraduate ethics education for
      clinical practitioners].
PG  - 867-72
FAU - Asai, Atsushi
AU  - Asai A
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Nihon Naika Gakkai Zasshi
JT  - Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal
      Medicine
JID - 19130210R
SB  - IM
MH  - *Education, Medical, Continuing
MH  - *Ethics
MH  - Japan
EDAT- 2010/06/29 06:00
MHDA- 2010/07/07 06:00
CRDT- 2010/06/29 06:00
PHST- 2010/06/29 06:00 [entrez]
PHST- 2010/06/29 06:00 [pubmed]
PHST- 2010/07/07 06:00 [medline]
AID - 10.2169/naika.99.867 [doi]
PST - ppublish
SO  - Nihon Naika Gakkai Zasshi. 2010 Apr 10;99(4):867-72. doi: 10.2169/naika.99.867.


PMID- 20577840
OWN - NLM
STAT- MEDLINE
DCOM- 20101223
LR  - 20220317
IS  - 1865-3774 (Electronic)
IS  - 0925-5710 (Linking)
VI  - 92
IP  - 1
DP  - 2010 Jul
TI  - Stem and progenitor cells in human umbilical cord blood.
PG  - 45-51
LID - 10.1007/s12185-010-0619-4 [doi]
AB  - Both stem cells and progenitor cells are present in umbilical cord blood (UCB) at
      a high frequency, making these cells a major target population for experimental
      and clinical studies. As the use of autologous or allogeneic hematopoietic stem
      cell transplantation in the treatment of various diseases has grown rapidly in
      recent years, the concept of UCB banking for future use has drawn increasing
      interest. Stem and progenitor cells derived from UCB offer multiple advantages
      over adult stem cells, such as their immaturity (which may play a significant
      role in reducing rejection after transplantation into a mismatched host) and
      ability to produce large quantities of homogeneous tissue or cells. These cells
      can also differentiate across tissue lineage boundaries into neural, cardiac,
      epithelial, hepatic, and dermal tissues. Human UCB provides an alternative cell
      source that is ethically acceptable and widely supported by the public. This
      paper summarizes the characteristics of human UCB-derived stem and progenitor
      cells and their potential therapeutic use for tissue and cell regeneration.
FAU - Lee, Myoung Woo
AU  - Lee MW
AD  - Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School 
      of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul, Korea.
FAU - Jang, In Keun
AU  - Jang IK
FAU - Yoo, Keon Hee
AU  - Yoo KH
FAU - Sung, Ki Woong
AU  - Sung KW
FAU - Koo, Hong Hoe
AU  - Koo HH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100625
PL  - Japan
TA  - Int J Hematol
JT  - International journal of hematology
JID - 9111627
SB  - IM
MH  - Cell Culture Techniques
MH  - Cell Lineage
MH  - Fetal Blood/*cytology
MH  - Humans
MH  - Immunophenotyping
MH  - Stem Cell Transplantation
MH  - Stem Cells/classification/*cytology
EDAT- 2010/06/26 06:00
MHDA- 2010/12/25 06:00
CRDT- 2010/06/26 06:00
PHST- 2009/12/10 00:00 [received]
PHST- 2010/05/25 00:00 [accepted]
PHST- 2010/05/17 00:00 [revised]
PHST- 2010/06/26 06:00 [entrez]
PHST- 2010/06/26 06:00 [pubmed]
PHST- 2010/12/25 06:00 [medline]
AID - 10.1007/s12185-010-0619-4 [doi]
PST - ppublish
SO  - Int J Hematol. 2010 Jul;92(1):45-51. doi: 10.1007/s12185-010-0619-4. Epub 2010
      Jun 25.


PMID- 20576075
OWN - NLM
STAT- MEDLINE
DCOM- 20100930
LR  - 20161020
IS  - 1552-6909 (Electronic)
IS  - 0090-0311 (Linking)
VI  - 39
IP  - 3
DP  - 2010 May-Jun
TI  - Foundations for social justice-based actions in maternal/infant nursing.
PG  - 320-7
LID - 10.1111/j.1552-6909.2010.01143.x [doi]
AB  - The purpose of this article is to discuss health disparities and inequities and
      their most significant effects on maternal/infant health. A literature background
      on the social context of justice and distinct ethical theories is provided.
      Different ethical approaches to guide interventions that can improve the health
      of mothers and infants are presented. By adopting an ethical framework of social 
      justice, nurses can better understand and thus influence outcomes and ameliorate 
      health disparities and inequalities.
FAU - Clingerman, Evelyn
AU  - Clingerman E
AD  - University of Texas at Austin, Austin, TX 78701-1499, USA.
      eclingerman@mail.nur.utexas.edu
FAU - Fowles, Eileen
AU  - Fowles E
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Obstet Gynecol Neonatal Nurs
JT  - Journal of obstetric, gynecologic, and neonatal nursing : JOGNN
JID - 8503123
SB  - IM
MH  - Ethical Theory
MH  - Female
MH  - Health Services Accessibility/ethics/organization & administration
MH  - *Health Status Disparities
MH  - *Healthcare Disparities/ethics/organization & administration
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - *Maternal-Child Nursing/ethics/organization & administration
MH  - Nurse's Role
MH  - Patient Advocacy/ethics
MH  - Philosophy, Nursing
MH  - Pregnancy
MH  - Pregnancy Outcome/epidemiology
MH  - Prenatal Care/ethics/organization & administration
MH  - Social Justice/*ethics
MH  - United States/epidemiology
EDAT- 2010/06/26 06:00
MHDA- 2010/10/01 06:00
CRDT- 2010/06/26 06:00
PHST- 2010/06/26 06:00 [entrez]
PHST- 2010/06/26 06:00 [pubmed]
PHST- 2010/10/01 06:00 [medline]
AID - S0884-2175(15)30279-3 [pii]
AID - 10.1111/j.1552-6909.2010.01143.x [doi]
PST - ppublish
SO  - J Obstet Gynecol Neonatal Nurs. 2010 May-Jun;39(3):320-7. doi:
      10.1111/j.1552-6909.2010.01143.x.


PMID- 20576023
OWN - NLM
STAT- MEDLINE
DCOM- 20110121
LR  - 20110826
IS  - 1423-0410 (Electronic)
IS  - 0042-9007 (Linking)
VI  - 99
IP  - 3
DP  - 2010 Oct
TI  - Payment, compensation and replacement--the ethics and motivation of blood and
      plasma donation.
PG  - 202-11
LID - 10.1111/j.1423-0410.2010.01360.x [doi]
AB  - The supply of blood and plasma to produce haemotherapies varies around the world,
      but all environments need donors to furnish the raw material. Many countries
      still lack adequate supply, and the question of what amounts of blood and plasma 
      are required for optimal treatment is still unresolved. The issue of compensating
      donors has been a controversial and emotive one in blood transfusion for many
      decades. Donors are conventionally classified as paid, voluntary or replacement, 
      and a level of stigma, based on safety and ethical considerations, has been
      attached to paid donation. This review points to evidence which renders many of
      these concerns redundant. Purist arguments against compensated donation have
      little basis in evidence and would lead to many of today's voluntary donors being
      designated as paid, because of the large range of incentives used to recruit and 
      retain them. Misplaced application of 'Titmussian' volunteerism has precipitated 
      its own safety and supply problems. Current systems of compensation and
      replacement are needed to maintain supplies of essential products and lead to
      safe products in controlled environments. We propose that a plurality of routes
      towards donation is an appropriate paradigm in the heterogeneous landscape of
      blood and plasma product supply.
CI  - (c) 2010 The Author(s). Vox Sanguinis (c) 2010 International Society of Blood
      Transfusion.
FAU - Farrugia, A
AU  - Farrugia A
AD  - Plasma Protein Therapeutics Association, Annapolis, MD 21401, USA.
      afarrugia@pptaglobal.org
FAU - Penrod, J
AU  - Penrod J
FAU - Bult, J M
AU  - Bult JM
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Vox Sang
JT  - Vox sanguinis
JID - 0413606
SB  - IM
CIN - Vox Sang. 2011 Aug;101(2):176-7. PMID: 21496053
MH  - Blood Donors/*ethics
MH  - *Blood Transfusion/economics/ethics
MH  - Ethics, Medical
MH  - Humans
MH  - *Motivation
MH  - *Plasma
MH  - *Reimbursement Mechanisms/economics/ethics
EDAT- 2010/06/26 06:00
MHDA- 2011/01/22 06:00
CRDT- 2010/06/26 06:00
PHST- 2010/06/26 06:00 [entrez]
PHST- 2010/06/26 06:00 [pubmed]
PHST- 2011/01/22 06:00 [medline]
AID - VOX1360 [pii]
AID - 10.1111/j.1423-0410.2010.01360.x [doi]
PST - ppublish
SO  - Vox Sang. 2010 Oct;99(3):202-11. doi: 10.1111/j.1423-0410.2010.01360.x.


PMID- 20575991
OWN - NLM
STAT- MEDLINE
DCOM- 20110317
LR  - 20100625
IS  - 1445-5994 (Electronic)
IS  - 1444-0903 (Linking)
VI  - 40
IP  - 5
DP  - 2010 May
TI  - Ethical issues associated with gifts provided to physicians by the pharmaceutical
      industry.
PG  - 321-2
LID - 10.1111/j.1445-5994.2010.02215.x [doi]
FAU - Komesaroff, P A
AU  - Komesaroff PA
LA  - eng
PT  - Comment
PT  - Editorial
PL  - Australia
TA  - Intern Med J
JT  - Internal medicine journal
JID - 101092952
SB  - IM
CON - Intern Med J. 2010 May;40(5):335-41. PMID: 20345507
MH  - Drug Industry/economics/*ethics
MH  - Gift Giving/*ethics
MH  - Humans
MH  - Physicians/economics/*ethics
EDAT- 2010/06/26 06:00
MHDA- 2011/03/18 06:00
CRDT- 2010/06/26 06:00
PHST- 2010/06/26 06:00 [entrez]
PHST- 2010/06/26 06:00 [pubmed]
PHST- 2011/03/18 06:00 [medline]
AID - IMJ2215 [pii]
AID - 10.1111/j.1445-5994.2010.02215.x [doi]
PST - ppublish
SO  - Intern Med J. 2010 May;40(5):321-2. doi: 10.1111/j.1445-5994.2010.02215.x.


PMID- 20575943
OWN - NLM
STAT- MEDLINE
DCOM- 20101223
LR  - 20191210
IS  - 1445-2197 (Electronic)
IS  - 1445-1433 (Linking)
VI  - 80
IP  - 4
DP  - 2010 Apr
TI  - Ethical dilemma for surgical educators.
PG  - 207-9
LID - 10.1111/j.1445-2197.2010.05240.x [doi]
FAU - Cartmill, John
AU  - Cartmill J
AD  - Australian School of Advanced Medicine, Macquarie University, Sydney, Australia.
FAU - Morgan, Michael
AU  - Morgan M
FAU - Eyers, Anthony
AU  - Eyers A
FAU - Butt, David
AU  - Butt D
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - ANZ J Surg
JT  - ANZ journal of surgery
JID - 101086634
SB  - IM
MH  - Education, Medical/*ethics/methods
MH  - General Surgery/*education
MH  - Hospitals, Teaching/*ethics
MH  - Humans
MH  - *Models, Educational
MH  - Outcome and Process Assessment, Health Care
MH  - Students, Medical
EDAT- 2010/06/26 06:00
MHDA- 2010/12/25 06:00
CRDT- 2010/06/26 06:00
PHST- 2010/06/26 06:00 [entrez]
PHST- 2010/06/26 06:00 [pubmed]
PHST- 2010/12/25 06:00 [medline]
AID - ANS5240 [pii]
AID - 10.1111/j.1445-2197.2010.05240.x [doi]
PST - ppublish
SO  - ANZ J Surg. 2010 Apr;80(4):207-9. doi: 10.1111/j.1445-2197.2010.05240.x.


PMID- 20574762
OWN - NLM
STAT- MEDLINE
DCOM- 20101028
LR  - 20211020
IS  - 1432-055X (Electronic)
IS  - 0003-2417 (Linking)
VI  - 59
IP  - 7
DP  - 2010 Jul
TI  - [Intrathecal opioid medication for perioperative analgesia in severely
      handicapped children undergoing spinal operations].
PG  - 614-20
LID - 10.1007/s00101-010-1733-7 [doi]
AB  - PURPOSE OF THE STUDY: Intrathecal opioids have been shown to be safe and
      effective for postoperative analgesia in healthy children for spinal surgery. The
      aim of this study was to evaluate the applicability of intrathecal opioids in
      severely handicapped children scheduled for spinal surgery. METHODS: With
      hospital ethical committee approval, patients with physical states III and IV of 
      the ASA classification requiring spinal surgery were retrospectively studied. In 
      addition to inhalational anesthesia with sevoflurane or intravenous anesthesia
      using propofol, morphine 20 microg/kgBW and sufentanil 1.5 microg/kgBW were
      administered intrathecally before surgery. After surgery an infusion of
      nalbuphine was started. Need for additional intraoperative and postoperative
      analgesics, time of extubation, postoperative pain scores and p(a)CO2 values as
      well as adverse effects were recorded. RESULTS: A total of 28 patients aged from 
      2.8 to 18.5 years (median 11.6 years) were studied. Immediate tracheal extubation
      in the operating room was possible in 17 patients and for 11 patients delayed
      extubation was elected. All patients were extubated within 24 h except for 1
      patient who received massive postoperative transfusions. In 26 out of 28 patients
      (93%) the combination of intrathecal opioids with postoperative nalbuphine
      provided adequate analgesia. Observed side effects were post-operative nausea and
      vomiting (PONV), pruritus and moderate hypoventilation. In two patients a change 
      to intravenous morphine therapy was necessary. CONCLUSION: The use of intrathecal
      opioids for perioperative pain control from spinal fusion in severely handicapped
      children is feasible. Intrathecal opioids provide adequate postoperative
      analgesia and allow early extubation without persisting relevant respiratory
      compromise in most of these patients.
FAU - Schmitz, A
AU  - Schmitz A
AD  - Anasthesieabteilung, Universitats-Kinderkliniken Zurich, Steinwiesstr. 75, 8032
      Zurich, Schweiz. achim.schmitz@kispi.uzh.ch
FAU - Salgo, B
AU  - Salgo B
FAU - Weiss, M
AU  - Weiss M
FAU - Dillier, C M
AU  - Dillier CM
FAU - Frotzler, A
AU  - Frotzler A
FAU - Gerber, A C
AU  - Gerber AC
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Intrathekale Opioidmedikation zur perioperativen Analgesie bei schwer behinderten
      Kindern mit Wirbelsaulenoperationen.
PL  - Germany
TA  - Anaesthesist
JT  - Der Anaesthesist
JID - 0370525
RN  - 0 (Analgesics, Opioid)
RN  - L2T84IQI2K (Nalbuphine)
SB  - IM
MH  - Adolescent
MH  - *Analgesia
MH  - Analgesics, Opioid/*administration & dosage/adverse effects/*therapeutic use
MH  - Child
MH  - Child, Preschool
MH  - *Disabled Children
MH  - Female
MH  - Humans
MH  - Injections, Spinal
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Nalbuphine/administration & dosage/adverse effects/therapeutic use
MH  - Pain/*drug therapy/etiology
MH  - Pain Measurement
MH  - Pain, Postoperative/drug therapy
MH  - *Perioperative Care
MH  - Postoperative Nausea and Vomiting/epidemiology/prevention & control
MH  - Pruritus/chemically induced/epidemiology
MH  - Retrospective Studies
MH  - Spine/*surgery
EDAT- 2010/06/25 06:00
MHDA- 2010/10/29 06:00
CRDT- 2010/06/25 06:00
PHST- 2010/06/25 06:00 [entrez]
PHST- 2010/06/25 06:00 [pubmed]
PHST- 2010/10/29 06:00 [medline]
AID - 10.1007/s00101-010-1733-7 [doi]
PST - ppublish
SO  - Anaesthesist. 2010 Jul;59(7):614-20. doi: 10.1007/s00101-010-1733-7.


PMID- 20574101
OWN - NLM
STAT- MEDLINE
DCOM- 20100716
LR  - 20151119
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 256
IP  - 1
DP  - 2010 Jul
TI  - Chronic obstructive pulmonary disease: longitudinal hyperpolarized (3)He MR
      imaging.
PG  - 280-9
LID - 10.1148/radiol.10091937 [doi]
AB  - PURPOSE: To quantitatively evaluate a small pilot group of ex-smokers with
      chronic obstructive pulmonary disease (COPD) and healthy volunteers during
      approximately 2 years by using hyperpolarized helium 3 ((3)He) magnetic resonance
      (MR) imaging. MATERIALS AND METHODS: All subjects provided written informed
      consent to the study protocol, which was approved by the local research ethics
      board and Health Canada and was compliant with the Personal Information
      Protection and Electronic Documents Act and HIPAA. Hyperpolarized (3)He MR
      imaging, hydrogen 1 MR imaging, spirometry, and plethysmography were performed in
      15 ex-smokers with COPD and five healthy volunteers (with the same mean age and
      age range) at baseline and 26 months +/- 2 (standard deviation) later. Apparent
      diffusion coefficients (ADCs) derived from (3)He MR imaging were calculated from 
      diffusion-weighted (3)He MR images, and (3)He ventilation defect volume (VDV) and
      ventilation defect percentage (VDP) were generated after manual segmentation of
      (3)He MR spin-density images. RESULTS: For subjects with COPD, significant
      increases in (3)He MR imaging-derived VDV (P = .03), VDP (P = .006), and ADC (P =
      .02) were detected, whereas there was no significant change in forced expiratory 
      volume in 1 second (FEV(1)) (P = .97). For healthy never-smokers, there was no
      significant change in imaging or pulmonary function measurements at follow-up.
      There was a significant correlation between changes in FEV(1) and changes in VDV 
      (r = -0.70, P = .02) and VDP (r = -0.70, P = .03). CONCLUSION: For this small
      pilot group of ex-smokers with COPD, (3)He MR imaging-derived VDV, VDP, and ADC
      measurements worsened significantly, but there was no significant change in
      FEV(1), suggesting increased sensitivity of hyperpolarized (3)He MR imaging for
      depicting COPD changes during short time periods.
FAU - Kirby, Miranda
AU  - Kirby M
AD  - Imaging Research Laboratories, Robarts Research Institute, London, ON, Canada.
FAU - Mathew, Lindsay
AU  - Mathew L
FAU - Wheatley, Andrew
AU  - Wheatley A
FAU - Santyr, Giles E
AU  - Santyr GE
FAU - McCormack, David G
AU  - McCormack DG
FAU - Parraga, Grace
AU  - Parraga G
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 206GF3GB41 (Helium)
SB  - IM
MH  - Aged
MH  - Diffusion Magnetic Resonance Imaging/*methods
MH  - Forced Expiratory Volume
MH  - Helium
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - Plethysmography
MH  - Pulmonary Disease, Chronic Obstructive/*diagnosis/*physiopathology
MH  - Smoking/adverse effects
MH  - Spirometry
MH  - Statistics, Nonparametric
MH  - Whole Body Imaging
EDAT- 2010/06/25 06:00
MHDA- 2010/07/17 06:00
CRDT- 2010/06/25 06:00
PHST- 2010/06/25 06:00 [entrez]
PHST- 2010/06/25 06:00 [pubmed]
PHST- 2010/07/17 06:00 [medline]
AID - 256/1/280 [pii]
AID - 10.1148/radiol.10091937 [doi]
PST - ppublish
SO  - Radiology. 2010 Jul;256(1):280-9. doi: 10.1148/radiol.10091937.


PMID- 20574096
OWN - NLM
STAT- MEDLINE
DCOM- 20100716
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 256
IP  - 1
DP  - 2010 Jul
TI  - Temporomandibular joint findings in adults with long-standing juvenile idiopathic
      arthritis: CT and MR imaging assessment.
PG  - 191-200
LID - 10.1148/radiol.10091810 [doi]
AB  - PURPOSE: To assess the long-term temporomandibular joint (TMJ) manifestations of 
      juvenile idiopathic arthritis (JIA), as depicted at computed tomography (CT) and 
      magnetic resonance (MR) imaging, in 47 adult patients. MATERIALS AND METHODS: The
      study was approved by a regional committee for medical research ethics, and
      informed consent was obtained from all patients. Forty-seven patients with JIA
      (32 women, 15 men; mean age, 35 years) were examined, on average, 30 years after 
      the initial diagnosis. The findings of TMJ imaging, including CT and MR imaging, 
      were evaluated by three observers. Bone and disk abnormalities, joint effusion,
      bone marrow abnormalities, and contrast enhancement were analyzed. RESULTS: The
      TMJs were involved in 33 (70%) of the 47 patients with JIA, with bilateral
      involvement in 29 patients. Slight to moderate contrast enhancement was observed 
      on the images obtained in 14 (42%) of the 33 patients with TMJ JIA abnormalities.
      All main joint components were abnormal in 28 of the 33 patients, mainly showing 
      flat deformed condyles, wide flat fossae, and thin or perforated disks in the
      normal position, or absent disks. Condylar concavity or bifidity, and secondary
      osteoarthritis were found in approximately half of the abnormal joints.
      CONCLUSION: Long-term JIA manifestations in the TMJs, as demonstrated at CT and
      MR imaging, were frequent, usually bilateral, and characterized by mandibular
      condyle and temporal bone deformities, abnormal disk morphology, and, rather
      frequently, osteoarthritis and mild synovitis.
FAU - Arvidsson, Linda Z
AU  - Arvidsson LZ
AD  - Department of Maxillofacial Radiology, Institute of Clinical Dentistry,
      University of Oslo, Blindern, Oslo, Norway. l.z.arvidsson@odont.uio.no
FAU - Smith, Hans-Jorgen
AU  - Smith HJ
FAU - Flato, Berit
AU  - Flato B
FAU - Larheim, Tore A
AU  - Larheim TA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adult
MH  - Arthritis, Juvenile/diagnostic imaging/*pathology
MH  - Chi-Square Distribution
MH  - Contrast Media
MH  - Female
MH  - Gadolinium DTPA
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Norway
MH  - Osteoarthritis/diagnostic imaging/pathology
MH  - Synovitis/diagnostic imaging/pathology
MH  - Temporomandibular Joint/diagnostic imaging/*pathology
MH  - Tomography, X-Ray Computed
EDAT- 2010/06/25 06:00
MHDA- 2010/07/17 06:00
CRDT- 2010/06/25 06:00
PHST- 2010/06/25 06:00 [entrez]
PHST- 2010/06/25 06:00 [pubmed]
PHST- 2010/07/17 06:00 [medline]
AID - 256/1/191 [pii]
AID - 10.1148/radiol.10091810 [doi]
PST - ppublish
SO  - Radiology. 2010 Jul;256(1):191-200. doi: 10.1148/radiol.10091810.


PMID- 20574092
OWN - NLM
STAT- MEDLINE
DCOM- 20100716
LR  - 20151119
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 256
IP  - 1
DP  - 2010 Jul
TI  - Distinguishing hypervascular pseudolesions of the liver from hypervascular
      hepatocellular carcinomas with gadoxetic acid-enhanced MR imaging.
PG  - 151-8
LID - 10.1148/radiol.10091885 [doi]
AB  - PURPOSE: To retrospectively determine findings at gadoxetic acid-enhanced
      magnetic resonance (MR) imaging in hypervascular pseudolesions that were observed
      at computed tomography (CT) during hepatic arteriography, with special focus on
      distinguishing these pseudolesions from hypervascular hepatocellular carcinomas
      (HCCs). MATERIALS AND METHODS: The institute ethics committee deemed study
      approval unnecessary. The study population comprised 80 patients (55 men, 25
      women) with chronic liver disease who underwent CT during hepatic arteriography
      and arterial portography, gadoxetic acid-enhanced MR imaging, and follow-up
      dynamic contrast material-enhanced CT. The diagnosis of 104 pseudolesions and 123
      HCCs was confirmed by means of histopathologic or multimodality evaluation. Two
      radiologists assessed the MR imaging findings of HCCs and pseudolesions in
      consensus, including the signal intensities (SIs) of the lesions on T2-weighted, 
      diffusion-weighted (DW), and contrast-enhanced hepatocyte-phase images. The
      findings of nodular pseudolesions and HCCs were compared with the Fisher exact
      test. Additionally, the hepatocyte-phase SI ratio (ratio of lesion SI to liver
      SI) for HCCs and pseudolesions was compared by means of the Mann-Whitney U test. 
      RESULTS: There were 62 wedge-shaped, 32 nodular, and 10 linear pseudolesions. On 
      gadoxetic acid-enhanced hepatocyte-phase MR images, 15% of pseudolesions (16 of
      104) were hypointense compared with surrounding liver tissue. The mean
      hepatocyte-phase SI ratio of HCCs (0.65 +/- 0.14 [standard deviation]) was
      significantly lower (P < .01) than that of the nodular pseudolesions (0.95 +/-
      0.11). The optimal cutoff value of hepatocyte-phase SI ratio for distinguishing
      between HCC and nodular pseudolesion was 0.84. No nodular pseudolesions were
      visible on DW images. CONCLUSION: Gadoxetic acid-enhanced hepatocyte-phase MR
      imaging and DW imaging could be used to distinguish hypervascular pseudolesions
      from hypervascular HCCs; a hepatocyte-phase SI ratio below 0.84 and visibility on
      DW images were findings specific for HCCs rather than pseudolesions.
FAU - Motosugi, Utaroh
AU  - Motosugi U
AD  - Department of Radiology, University of Yamanashi, Chuo-shi, Yamanashi, Japan.
      utaroh-motosugi@nifty.com
FAU - Ichikawa, Tomoaki
AU  - Ichikawa T
FAU - Sou, Hironobu
AU  - Sou H
FAU - Sano, Katsuhiro
AU  - Sano K
FAU - Tominaga, Licht
AU  - Tominaga L
FAU - Muhi, Ali
AU  - Muhi A
FAU - Araki, Tsutomu
AU  - Araki T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - 0 (gadolinium ethoxybenzyl DTPA)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Aged
MH  - Carcinoma, Hepatocellular/blood supply/*diagnosis/pathology
MH  - Chi-Square Distribution
MH  - *Contrast Media
MH  - Diagnosis, Differential
MH  - Diffusion Magnetic Resonance Imaging
MH  - Female
MH  - *Gadolinium DTPA
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Liver/blood supply
MH  - Liver Diseases/*diagnosis/pathology
MH  - Liver Neoplasms/blood supply/*diagnosis/pathology
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Neovascularization, Pathologic/*diagnosis/pathology
MH  - ROC Curve
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - Statistics, Nonparametric
MH  - Tomography, X-Ray Computed
EDAT- 2010/06/25 06:00
MHDA- 2010/07/17 06:00
CRDT- 2010/06/25 06:00
PHST- 2010/06/25 06:00 [entrez]
PHST- 2010/06/25 06:00 [pubmed]
PHST- 2010/07/17 06:00 [medline]
AID - 256/1/151 [pii]
AID - 10.1148/radiol.10091885 [doi]
PST - ppublish
SO  - Radiology. 2010 Jul;256(1):151-8. doi: 10.1148/radiol.10091885.


PMID- 20574066
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20110322
IS  - 1946-6242 (Electronic)
IS  - 1946-6234 (Linking)
VI  - 2
IP  - 37
DP  - 2010 Jun 23
TI  - Multidimensional results reporting to participants in genomic studies: getting it
      right.
PG  - 37cm19
LID - 10.1126/scitranslmed.3000809 [doi]
AB  - Recent surveys about participation in cohort studies reconfirm that participants 
      value and desire the return of research results to a degree that is out of step
      with the restrictive recommendations of various ethics advisory groups, which
      have historically limited disclosure based on clinician value judgments and the
      severity and treatability of the disease in question, among other factors. Rather
      than framing the current inconclusive ethics discussion as a standstill among
      competing ethical principles and their potential applicability, we introduce a
      new element, communicability (that is, those properties of a message that will
      determine how likely it is that its informational intent will be grasped by the
      study participant), as the subject of empirical research to align participants'
      goals with beneficent and responsible results reporting. Structural changes in
      research design, combined with governance changes in assessing impact, allow us
      to move beyond a binary construction of report/do not report and to create a
      structure in which the communicability of the message and the participants'
      preferences are variables in a function that affects results reporting. Here we
      illustrate this structure and its principles.
FAU - Kohane, Isaac S
AU  - Kohane IS
AD  - Children's Hospital Informatics Program, Children's Hospital, Boston, MA 02115,
      USA.
FAU - Taylor, Patrick L
AU  - Taylor PL
LA  - eng
GR  - 1RC1HG005491-01/HG/NHGRI NIH HHS/United States
GR  - 1RC1LM010470-01/LM/NLM NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Sci Transl Med
JT  - Science translational medicine
JID - 101505086
SB  - IM
CIN - Sci Transl Med. 2011 Feb 16;3(70):70le1. PMID: 21325615
MH  - Cohort Studies
MH  - Ethics, Research
MH  - Genomics/ethics/*methods/standards
MH  - Humans
MH  - Information Dissemination/*ethics
MH  - Patient Education as Topic/*ethics/*standards
MH  - Patient Participation
MH  - Reproducibility of Results
EDAT- 2010/06/25 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/06/25 06:00
PHST- 2010/06/25 06:00 [entrez]
PHST- 2010/06/25 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 2/37/37cm19 [pii]
AID - 10.1126/scitranslmed.3000809 [doi]
PST - ppublish
SO  - Sci Transl Med. 2010 Jun 23;2(37):37cm19. doi: 10.1126/scitranslmed.3000809.


PMID- 20573764
OWN - NLM
STAT- MEDLINE
DCOM- 20100706
LR  - 20181023
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 340
DP  - 2010 Jun 23
TI  - How to think like an ethicist.
PG  - c3256
LID - 10.1136/bmj.c3256 [doi]
LID - bmj.c3256 [pii]
FAU - Sokol, Daniel K
AU  - Sokol DK
AD  - Imperial College London. daniel.sokol@talk21.com
LA  - eng
PT  - Journal Article
DEP - 20100623
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
SB  - IM
CIN - BMJ. 2010;341:c3702. PMID: 20659986
MH  - *Bioethical Issues
MH  - Ethics, Medical/*education
EDAT- 2010/06/25 06:00
MHDA- 2010/07/07 06:00
CRDT- 2010/06/25 06:00
PHST- 2010/06/25 06:00 [entrez]
PHST- 2010/06/25 06:00 [pubmed]
PHST- 2010/07/07 06:00 [medline]
AID - 10.1136/bmj.c3256 [doi]
PST - epublish
SO  - BMJ. 2010 Jun 23;340:c3256. doi: 10.1136/bmj.c3256.


PMID- 20573742
OWN - NLM
STAT- MEDLINE
DCOM- 20101210
LR  - 20161125
IS  - 1468-2044 (Electronic)
IS  - 0003-9888 (Linking)
VI  - 95
IP  - 11
DP  - 2010 Nov
TI  - What do research ethics committees say about applications to conduct research
      involving children?
PG  - 915-7
LID - 10.1136/adc.2009.172395 [doi]
AB  - OBJECTIVE: To identify issues raised by research ethics committees (RECs) in
      letters about applications to conduct research involving children. METHODS:
      Analysis of 80 provisional and unfavourable opinion decision letters written by
      RECs in response to applications to conduct research involving child
      participants. RESULTS: RECs were most likely to be concerned about issues
      relating to consent, recruitment, care and protection of participants, scientific
      design and confidentiality. RECs focused on children's status as "vulnerable".
      They sought to ensure that children would be protected, that appropriate written 
      language would be used to communicate with children and that an appropriate
      person would give consent for children to participate. IMPLICATIONS: Researchers 
      should be attentive to issues of potential vulnerability when preparing
      applications. REC letters may be improved by giving clear and explicit reasons
      for their opinions.
FAU - Angell, E
AU  - Angell E
AD  - Social Sciences Research Group, Department of Health Sciences, University of
      Leicester, Leicester, UK. elj1@le.ac.uk
FAU - Biggs, H
AU  - Biggs H
FAU - Gahleitner, F
AU  - Gahleitner F
FAU - Dixon-Woods, M
AU  - Dixon-Woods M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100623
PL  - England
TA  - Arch Dis Child
JT  - Archives of disease in childhood
JID - 0372434
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child Welfare/ethics
MH  - Child, Preschool
MH  - Confidentiality/ethics
MH  - Decision Making
MH  - *Ethics Committees, Research
MH  - *Ethics, Research
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Informed Consent/ethics
MH  - Patient Education as Topic/ethics
MH  - Pediatrics/*ethics
MH  - United Kingdom
EDAT- 2010/06/25 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/06/25 06:00
PHST- 2010/06/25 06:00 [entrez]
PHST- 2010/06/25 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - adc.2009.172395 [pii]
AID - 10.1136/adc.2009.172395 [doi]
PST - ppublish
SO  - Arch Dis Child. 2010 Nov;95(11):915-7. doi: 10.1136/adc.2009.172395. Epub 2010
      Jun 23.


PMID- 20572110
OWN - NLM
STAT- MEDLINE
DCOM- 20101013
LR  - 20100628
IS  - 1097-0223 (Electronic)
IS  - 0197-3851 (Linking)
VI  - 30
IP  - 7
DP  - 2010 Jul
TI  - Management of red cell alloimmunisation in pregnancy: the non-invasive monitoring
      of the disease.
PG  - 668-73
LID - 10.1002/pd.2551 [doi]
AB  - Haemolytic disease of the fetus and newborn (HDFN) due to red cell
      alloimmunization was a significant cause of fetal and neonatal morbidity and
      mortality until the introduction of anti-D immunoglobulin, which has dramatically
      changed the incidence of the disease. However, it is still a major problem in
      affected pregnancies. The emphasis of current clinical management has shifted
      from an invasive approach to non-invasive monitoring of the disease. The key
      elements of the modern management are determining which fetuses are at risk of
      HDFN with the use of cell-free fetal DNA in maternal plasma (fetal RHD genotype) 
      and the follow-up of antigen positive fetuses by Doppler ultrasonography to
      detect anaemia severe enough to need treatment. When anaemia is suspected, an
      invasive approach is still required in a timely manner for confirmation of the
      degree of anaemia and to administer blood transfusions. This non-invasive
      approach prevents unnecessary administration of human-derived blood products,
      with the consequent ethical and cost implications and most importantly avoids
      iatrogenic conversion of mild to severe disease by avoiding need for techniques
      such as amniocentesis. The potential problem of the non-invasive approach is the 
      reduction in the total number of invasive procedures, with the subsequent
      difficulty of maintaining the skills required to perform them.
CI  - (c) 2010 John Wiley & Sons, Ltd.
FAU - Illanes, Sebastian
AU  - Illanes S
AD  - Fetal Medicine Unit, Department of Obstetrics and Gynecology, Universidad de los 
      Andes, San Carlos de Apoquindo, Santiago, Chile. sillanes@uandes.cl
FAU - Soothill, Peter
AU  - Soothill P
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Prenat Diagn
JT  - Prenatal diagnosis
JID - 8106540
RN  - 0 (Rh-Hr Blood-Group System)
RN  - 0 (Rho(D) Immune Globulin)
SB  - IM
MH  - Erythroblastosis, Fetal/blood/immunology/*therapy
MH  - Erythrocytes/*immunology
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Infant, Newborn
MH  - Pregnancy
MH  - Rh-Hr Blood-Group System/genetics/*immunology
MH  - Rho(D) Immune Globulin/immunology/*therapeutic use
RF  - 66
EDAT- 2010/06/24 06:00
MHDA- 2010/10/14 06:00
CRDT- 2010/06/24 06:00
PHST- 2010/06/24 06:00 [entrez]
PHST- 2010/06/24 06:00 [pubmed]
PHST- 2010/10/14 06:00 [medline]
AID - 10.1002/pd.2551 [doi]
PST - ppublish
SO  - Prenat Diagn. 2010 Jul;30(7):668-73. doi: 10.1002/pd.2551.


PMID- 20571715
OWN - NLM
STAT- MEDLINE
DCOM- 20100803
LR  - 20220330
IS  - 1135-5727 (Print)
IS  - 1135-5727 (Linking)
VI  - 84
IP  - 2
DP  - 2010 Mar-Apr
TI  - [The ethical aspects of population screening programme of rare diseases].
PG  - 121-36
LID - S1135-57272010000200002 [pii]
AB  - The Committee on Ethics of the Instituto de Investigacion de Enfermedades Raras
      (CEIIER) of the Spanish National Institute of Health Carlos III, presents this
      article dealing with ethical guidelines regarding the implementation of screening
      population programmes with special emphasis on genetic screening. After a
      critical review it has been addressed 24 recommendations concerning 14 topics:
      evaluation of the opportunity of the programme, including ethical analysis
      besides scientific evidences and cost/benefits issues; the need to differentiate 
      between research and public health intervention and to built a specific and
      comprehensive programme; the creation of an interdisciplinary working group which
      control its implementation and prepare a protocol including justification,
      development, therapeutic or preventive actions and follow-up activities; the
      review of the programme by an independent Ethical committee; the guarantee of the
      voluntary, universal and equitable population access, which requires sufficient
      information on the programme and their specific relevant facts, as incidental
      detection of heterozygous state in minors in newborn screening and the relevance 
      of non directive genetic counselling specially in prenatal screening offered to
      pregnant women; considerations regarding future uses of samples for research
      purposes; total quality and periodic programme evaluation; guarantee of personal 
      data confidentiality and the conflict of interest statement of the members of all
      the Committees involved in the programme.
FAU - Pampols Ros, Teresa
AU  - Pampols Ros T
AD  - Comite de Etica, Instituto de Investigacion de Enfermedades Raras (IIER), Spain.
FAU - Terracini, Benedetto
AU  - Terracini B
FAU - de Abajo Iglesias, Francisco J
AU  - de Abajo Iglesias FJ
FAU - Feito Grande, Lydia
AU  - Feito Grande L
FAU - Martin-Arribas, M Concepcion
AU  - Martin-Arribas MC
FAU - Fernandez Soria, Jose Maria
AU  - Fernandez Soria JM
FAU - Redondo Martin Del Olmo, Tomas
AU  - Redondo Martin Del Olmo T
FAU - Campos Castello, Jaime
AU  - Campos Castello J
FAU - Herrera Carranza, Joaquin
AU  - Herrera Carranza J
FAU - Judez Gutierrez, Javier
AU  - Judez Gutierrez J
FAU - Abascal Alonso, Moises
AU  - Abascal Alonso M
FAU - Morales Piga, Antonio
AU  - Morales Piga A
CN  - Comite de Etica, Instituto de Investigacion de Enfermedades Raras
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Practice Guideline
TT  - Recomendaciones sobre los aspectos eticos de los programas de cribado de
      poblacion para enfermedades raras.
PL  - Spain
TA  - Rev Esp Salud Publica
JT  - Revista espanola de salud publica
JID - 9600212
SB  - IM
MH  - Humans
MH  - Mass Screening/*ethics
MH  - Rare Diseases/*diagnosis
EDAT- 2010/06/24 06:00
MHDA- 2010/08/04 06:00
CRDT- 2010/06/24 06:00
PHST- 2010/06/24 06:00 [entrez]
PHST- 2010/06/24 06:00 [pubmed]
PHST- 2010/08/04 06:00 [medline]
AID - S1135-57272010000200002 [pii]
AID - 10.1590/s1135-57272010000200002 [doi]
PST - ppublish
SO  - Rev Esp Salud Publica. 2010 Mar-Apr;84(2):121-36. doi:
      10.1590/s1135-57272010000200002.


PMID- 20571509
OWN - NLM
STAT- MEDLINE
DCOM- 20110207
LR  - 20211020
IS  - 1476-5438 (Electronic)
IS  - 1018-4813 (Linking)
VI  - 18
IP  - 10
DP  - 2010 Oct
TI  - Carrier screening for beta-thalassaemia: a review of international practice.
PG  - 1077-83
LID - 10.1038/ejhg.2010.90 [doi]
AB  - beta-thalassaemia is one of the most common single-gene inherited conditions in
      the world, and thalassaemia carrier screening is the most widely performed
      genetic screening test, occurring in many different countries. beta-thalassaemia 
      carrier screening programmes provide a unique opportunity to compare the delivery
      of carrier screening programmes carried out in different cultural, religious and 
      social contexts. This review compares the key characteristics of
      beta-thalassaemia carrier screening programmes implemented in countries across
      the world so that the differences and similarities between the programmes can be 
      assessed. The manner in which thalassaemia carrier screening programmes are
      structured among different populations varies greatly in several aspects,
      including whether the programmes are mandatory or voluntary, the education and
      counselling provided and whether screening is offered pre-pregnancy or
      antenatally. National and international guidelines make recommendations on the
      most appropriate ways in which genetic carrier screening programmes should be
      conducted; however, these recommendations are not followed in many programmes. We
      discuss the implications for the ethical and acceptable implementation of
      population carrier screening and identify a paucity of research into the outcomes
      of thalassaemia screening programmes, despite the fact that thalassaemia
      screening is so commonly conducted.
FAU - Cousens, Nicole E
AU  - Cousens NE
AD  - Murdoch Childrens Research Institute, Parkville, Victoria, Australia.
FAU - Gaff, Clara L
AU  - Gaff CL
FAU - Metcalfe, Sylvia A
AU  - Metcalfe SA
FAU - Delatycki, Martin B
AU  - Delatycki MB
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100623
PL  - England
TA  - Eur J Hum Genet
JT  - European journal of human genetics : EJHG
JID - 9302235
SB  - IM
MH  - Female
MH  - *Genetic Carrier Screening
MH  - Genetic Counseling
MH  - *Genetic Testing/standards
MH  - Heterozygote
MH  - Humans
MH  - Informed Consent
MH  - Internationality
MH  - Mass Screening
MH  - Patient Education as Topic
MH  - Practice Guidelines as Topic
MH  - Pregnancy
MH  - Prenatal Diagnosis
MH  - World Health Organization
MH  - *beta-Thalassemia/diagnosis/epidemiology/prevention & control
PMC - PMC2987452
EDAT- 2010/06/24 06:00
MHDA- 2011/02/08 06:00
CRDT- 2010/06/24 06:00
PHST- 2010/06/24 06:00 [entrez]
PHST- 2010/06/24 06:00 [pubmed]
PHST- 2011/02/08 06:00 [medline]
AID - ejhg201090 [pii]
AID - 10.1038/ejhg.2010.90 [doi]
PST - ppublish
SO  - Eur J Hum Genet. 2010 Oct;18(10):1077-83. doi: 10.1038/ejhg.2010.90. Epub 2010
      Jun 23.


PMID- 20571130
OWN - NLM
STAT- MEDLINE
DCOM- 20110127
LR  - 20220409
IS  - 1740-7753 (Electronic)
IS  - 1740-7745 (Linking)
VI  - 7
IP  - 5
DP  - 2010 Oct
TI  - Bayesian adaptive randomization designs for targeted agent development.
PG  - 584-96
LID - 10.1177/1740774510373120 [doi]
AB  - BACKGROUND: With better understanding of the disease's etiology and mechanism,
      many targeted agents are being developed to tackle the root cause of problems,
      hoping to offer more effective and less toxic therapies. Targeted agents,
      however, do not work for everyone. Hence, the development of target agents
      requires the evaluation of prognostic and predictive markers. In addition, upon
      the identification of each patient's marker profile, it is desirable to treat
      patients with best available treatments in the clinical trial accordingly.
      METHODS: Many designs have recently been proposed for the development of targeted
      agents. These include the simple randomization design, marker stratified design, 
      marker strategy design, efficient targeted design, etc. In contrast to the
      frequentist designs with equal randomization, we propose novel Bayesian adaptive 
      randomization designs that allow evaluating treatments and markers
      simultaneously, while providing more patients with effective treatments according
      to the patients' marker profiles. Early stopping rules can be implemented to
      increase the efficiency of the designs. RESULTS: Through simulations, the
      operating characteristics of different designs are compared and contrasted. By
      carefully choosing the design parameters, types I and II errors can be controlled
      for Bayesian designs. By incorporating adaptive randomization and early stopping 
      rules, the proposed designs incorporate rational learning from the interim data
      to make informed decisions. Bayesian design also provides a formal way to
      incorporate relevant prior information. Compared with previously published
      designs, the proposed design can be more efficient, more ethical, and is also
      more flexible in the study conduct. LIMITATIONS: Response adaptive randomization 
      requires the response to be assessed in a relatively short time period. The
      infrastructure must be set up to allow timely and more frequent monitoring of
      interim results. CONCLUSION: Bayesian adaptive randomization designs are
      distinctively suitable for the development of multiple targeted agents with
      multiple biomarkers.
FAU - Lee, J Jack
AU  - Lee JJ
AD  - Department of Biostatistics, The University of Texas M D Anderson Cancer Center, 
      Houston, TX 77030, USA. jjlee@mdanderson.org
FAU - Xuemin Gu
AU  - Xuemin Gu
FAU - Suyu Liu
AU  - Suyu Liu
LA  - eng
GR  - P30 CA016672/CA/NCI NIH HHS/United States
GR  - CA 16672/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20100622
PL  - England
TA  - Clin Trials
JT  - Clinical trials (London, England)
JID - 101197451
RN  - 0 (Biomarkers)
SB  - IM
MH  - Bayes Theorem
MH  - *Biomarkers
MH  - Humans
MH  - *Molecular Targeted Therapy
MH  - Randomized Controlled Trials as Topic/*methods
MH  - *Research Design
MH  - Statistics as Topic/*methods
PMC - PMC5110207
MID - NIHMS828008
EDAT- 2010/06/24 06:00
MHDA- 2011/01/29 06:00
CRDT- 2010/06/24 06:00
PHST- 2010/06/24 06:00 [entrez]
PHST- 2010/06/24 06:00 [pubmed]
PHST- 2011/01/29 06:00 [medline]
AID - 1740774510373120 [pii]
AID - 10.1177/1740774510373120 [doi]
PST - ppublish
SO  - Clin Trials. 2010 Oct;7(5):584-96. doi: 10.1177/1740774510373120. Epub 2010 Jun
      22.


PMID- 20570755
OWN - NLM
STAT- MEDLINE
DCOM- 20110307
LR  - 20211020
IS  - 1559-2030 (Electronic)
IS  - 1551-7144 (Linking)
VI  - 31
IP  - 5
DP  - 2010 Sep
TI  - The ethics of sham surgery on research subjects with cognitive impairments that
      affect decision-making capacity.
PG  - 407-10
LID - 10.1016/j.cct.2010.05.009 [doi]
AB  - Populations recruited to participate in sham surgery clinical trials sometimes
      include patients with cognitive impairments that affect decision-making capacity.
      In this commentary we examine arguments for and against including these patients 
      in sham surgery clinical trials. We argue that patients with cognitive
      impairments that affect decision-making capacity should not be excluded from a
      sham surgery clinical trial if there are scientific reasons for including them in
      the study and basic ethical requirements for clinical research are met.
CI  - Published by Elsevier Inc.
FAU - Resnik, David B
AU  - Resnik DB
AD  - National Institute of Environmental Health Sciences, National Institutes of
      Health, Research Triangle Park, NC 27709, USA. resnikd@niehs.nih.gov
FAU - Miller, Frank
AU  - Miller F
LA  - eng
GR  - ZIA ES102646-01/ImNIH/Intramural NIH HHS/United States
GR  - ZIA ES102646-02/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
DEP - 20100604
PL  - United States
TA  - Contemp Clin Trials
JT  - Contemporary clinical trials
JID - 101242342
RN  - 0 (Placebos)
SB  - IM
MH  - Advance Directives
MH  - Clinical Trials as Topic/ethics
MH  - Cognition Disorders/*psychology
MH  - Decision Making/*ethics
MH  - *Ethics, Research
MH  - *General Surgery
MH  - Humans
MH  - Informed Consent/ethics
MH  - *Placebos
MH  - *Research Subjects
PMC - PMC2930142
MID - NIHMS211728
EDAT- 2010/06/24 06:00
MHDA- 2011/03/08 06:00
CRDT- 2010/06/24 06:00
PHST- 2010/01/05 00:00 [received]
PHST- 2010/05/18 00:00 [revised]
PHST- 2010/05/26 00:00 [accepted]
PHST- 2010/06/24 06:00 [entrez]
PHST- 2010/06/24 06:00 [pubmed]
PHST- 2011/03/08 06:00 [medline]
AID - S1551-7144(10)00097-2 [pii]
AID - 10.1016/j.cct.2010.05.009 [doi]
PST - ppublish
SO  - Contemp Clin Trials. 2010 Sep;31(5):407-10. doi: 10.1016/j.cct.2010.05.009. Epub 
      2010 Jun 4.


PMID- 20570563
OWN - NLM
STAT- MEDLINE
DCOM- 20101220
LR  - 20100715
IS  - 1472-6491 (Electronic)
IS  - 1472-6483 (Linking)
VI  - 21
IP  - 1
DP  - 2010 Jul
TI  - Conversion and non-conversion approach to preimplantation diagnosis for
      chromosomal rearrangements in 475 cycles.
PG  - 93-9
LID - 10.1016/j.rbmo.2010.04.003 [doi]
AB  - Due to the limitations of preimplantation genetic diagnosis (PGD) for chromosomal
      rearrangements by interphase fluorescent in-situ hybridization (FISH) analysis, a
      method for obtaining chromosomes from single blastomeres was introduced by their 
      fusion with enucleated or intact mouse zygotes, followed by FISH analysis of the 
      resulting heterokaryons. Although this allowed a significant improvement in the
      accuracy of testing of both maternally and paternally derived translocations, it 
      is still labour intensive and requires the availability of fertilized mouse
      oocytes, also creating ethical issues related to the formation of interspecies
      heterokaryons. This method was modified with a chemical conversion procedure that
      has now been clinically applied for the first time on 877 embryos from PGD cycles
      for chromosomal rearrangements and has become the method of choice for performing
      PGD for structural rearrangements. This is presented within the context of
      overall experience of 475 PGD cycles for translocations with pre-selection and
      transfer of balanced or normal embryos in 342 (72%) of these cycles, which
      resulted in 131 clinical pregnancies (38%), with healthy deliveries of 113
      unaffected children. The spontaneous abortion rate in these cycles was as low as 
      17%, which confirms an almost five-fold reduction of spontaneous abortion rate
      following PGD for chromosomal rearrangements.
CI  - 2010 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
FAU - Kuliev, Anver
AU  - Kuliev A
AD  - Reproductive Genetics Institute, Chicago, IL, USA. anverkuliev@hotmail.com
FAU - Janzen, Jeanine Cieslak
AU  - Janzen JC
FAU - Zlatopolsky, Zev
AU  - Zlatopolsky Z
FAU - Kirillova, Irina
AU  - Kirillova I
FAU - Ilkevitch, Yury
AU  - Ilkevitch Y
FAU - Verlinsky, Yury
AU  - Verlinsky Y
LA  - eng
PT  - Journal Article
DEP - 20100404
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
SB  - IM
MH  - Abortion, Spontaneous/prevention & control
MH  - Animals
MH  - *Chromosome Aberrations
MH  - Female
MH  - Genetic Testing/*methods
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Mice
MH  - Pregnancy
MH  - Preimplantation Diagnosis/*methods
MH  - *Translocation, Genetic
EDAT- 2010/06/24 06:00
MHDA- 2010/12/21 06:00
CRDT- 2010/06/24 06:00
PHST- 2009/08/19 00:00 [received]
PHST- 2010/01/22 00:00 [revised]
PHST- 2010/02/25 00:00 [accepted]
PHST- 2010/06/24 06:00 [entrez]
PHST- 2010/06/24 06:00 [pubmed]
PHST- 2010/12/21 06:00 [medline]
AID - S1472-6483(10)00180-X [pii]
AID - 10.1016/j.rbmo.2010.04.003 [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2010 Jul;21(1):93-9. doi: 10.1016/j.rbmo.2010.04.003. Epub 
      2010 Apr 4.


PMID- 20569997
OWN - NLM
STAT- MEDLINE
DCOM- 20111018
LR  - 20110609
IS  - 1872-6976 (Electronic)
IS  - 0167-4943 (Linking)
VI  - 53
IP  - 1
DP  - 2011 Jul-Aug
TI  - Cancer in home care: unintended weight loss and ethical challenges. A
      cross-sectional study of older people at 11 sites in Europe.
PG  - 64-9
LID - 10.1016/j.archger.2010.05.001 [doi]
AB  - The aim of this study was to compare unintended weight loss in cancer patients to
      other elderly. Home care users, aged >/=65 from urban areas at 11 sites in Europe
      (N=4010) were assessed with the Resident Assessment Instrument for Home Care.
      Epidemiological and medical characteristics of clients and service utilization
      were recorded. A total of 321 (8%) patients had a cancer diagnosis; they were on 
      average 80.4+/-7.3 years. Socio-demographic, functional and clinical parameters
      revealed small variations in the two groups. Compared to the non-cancer group,
      they more frequently suffered from: severe malnutrition (odds ratio=OR=2.4)
      unintended weight loss (OR=2.0), had been hospitalized during the last 6 months
      (OR=1.8). Older patients with cancer suffer more frequently from problems
      associated with nutrition than non-cancer patients. A comprehensive assessment
      could lead to better management of food and fluid supply based on basic ethical
      principles.
CI  - Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Sorbye, Liv Wergeland
AU  - Sorbye LW
AD  - Diakonhjemmet University College, Box. 184, Vinderen, N-0319 Oslo, Norway.
      sorbye@diakonhjemmet.no
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100531
PL  - Netherlands
TA  - Arch Gerontol Geriatr
JT  - Archives of gerontology and geriatrics
JID - 8214379
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cross-Sectional Studies
MH  - Europe/epidemiology
MH  - Female
MH  - Geriatric Assessment/statistics & numerical data
MH  - Home Care Services/ethics/*statistics & numerical data
MH  - Humans
MH  - Male
MH  - Malnutrition/epidemiology
MH  - Neoplasms/*epidemiology
MH  - Severity of Illness Index
MH  - *Weight Loss
EDAT- 2010/06/24 06:00
MHDA- 2011/10/19 06:00
CRDT- 2010/06/24 06:00
PHST- 2010/01/14 00:00 [received]
PHST- 2010/04/26 00:00 [revised]
PHST- 2010/04/28 00:00 [accepted]
PHST- 2010/06/24 06:00 [entrez]
PHST- 2010/06/24 06:00 [pubmed]
PHST- 2011/10/19 06:00 [medline]
AID - S0167-4943(10)00126-3 [pii]
AID - 10.1016/j.archger.2010.05.001 [doi]
PST - ppublish
SO  - Arch Gerontol Geriatr. 2011 Jul-Aug;53(1):64-9. doi:
      10.1016/j.archger.2010.05.001. Epub 2010 May 31.


PMID- 20569703
OWN - NLM
STAT- MEDLINE
DCOM- 20100715
LR  - 20101014
IS  - 1097-6744 (Electronic)
IS  - 0002-8703 (Linking)
VI  - 159
IP  - 6
DP  - 2010 Jun
TI  - Maximizing scientific knowledge from randomized clinical trials.
PG  - 937-43
LID - 10.1016/j.ahj.2010.03.002 [doi]
AB  - Trialists have an ethical and financial responsibility to plan and conduct
      clinical trials in a manner that will maximize the scientific knowledge gained
      from the trial. However, the amount of scientific information generated by
      randomized clinical trials in cardiovascular medicine is highly variable.
      Generation of trial databases and/or biobanks originating in large randomized
      clinical trials has successfully increased the knowledge obtained from those
      trials. At the 10th Cardiovascular Trialist Workshop, possibilities and pitfalls 
      in designing and accessing clinical trial databases were discussed by a group of 
      trialists. This review focuses on the arguments for conducting posttrial database
      studies and presents examples of studies in which posttrial knowledge generation 
      has been substantial. Possible strategies to ensure successful trial database or 
      biobank generation are discussed, in particular with respect to collaboration
      with the trial sponsor and to analytic pitfalls. The advantages of creating
      screening databases in conjunction with a given clinical trial are described; and
      finally, the potential for posttrial database studies to become a platform for
      training young scientists is outlined.
CI  - Copyright 2010 Mosby, Inc. All rights reserved.
FAU - Gustafsson, Finn
AU  - Gustafsson F
AD  - Rigshospitalet, Department of Cardiology, University of Copenhagen, Copenhagen,
      Denmark. finng@dadlnet.dk
FAU - Atar, Dan
AU  - Atar D
FAU - Pitt, Bertram
AU  - Pitt B
FAU - Zannad, Faiez
AU  - Zannad F
FAU - Pfeffer, Marc A
AU  - Pfeffer MA
CN  - participants in 10th Cardiovascular Clinical Trialists Workshop
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Am Heart J
JT  - American heart journal
JID - 0370465
SB  - IM
CIN - Am Heart J. 2010 Oct;160(4):e33. PMID: 20934547
MH  - Cardiovascular Diseases/*therapy
MH  - Data Collection
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - *Randomized Controlled Trials as Topic
RF  - 28
EDAT- 2010/06/24 06:00
MHDA- 2010/07/16 06:00
CRDT- 2010/06/24 06:00
PHST- 2010/01/24 00:00 [received]
PHST- 2010/03/02 00:00 [accepted]
PHST- 2010/06/24 06:00 [entrez]
PHST- 2010/06/24 06:00 [pubmed]
PHST- 2010/07/16 06:00 [medline]
AID - S0002-8703(10)00179-1 [pii]
AID - 10.1016/j.ahj.2010.03.002 [doi]
PST - ppublish
SO  - Am Heart J. 2010 Jun;159(6):937-43. doi: 10.1016/j.ahj.2010.03.002.


PMID- 20569268
OWN - NLM
STAT- MEDLINE
DCOM- 20100712
LR  - 20100623
IS  - 1469-8749 (Electronic)
IS  - 0012-1622 (Linking)
VI  - 52
IP  - 6
DP  - 2010 Jun
TI  - Measuring outcomes: an ethical premise in management of childhood disability.
PG  - 501
LID - 10.1111/j.1469-8749.2010.03688.x [doi]
FAU - Dan, Bernard
AU  - Dan B
LA  - eng
PT  - Editorial
PL  - England
TA  - Dev Med Child Neurol
JT  - Developmental medicine and child neurology
JID - 0006761
SB  - IM
MH  - Child
MH  - Developmental Disabilities/*diagnosis/*therapy
MH  - Evidence-Based Medicine/ethics/methods
MH  - Humans
MH  - Neurology/*ethics/*methods
MH  - Pediatrics/*ethics/*methods
MH  - Treatment Outcome
EDAT- 2010/06/24 06:00
MHDA- 2010/07/14 06:00
CRDT- 2010/06/24 06:00
PHST- 2010/06/24 06:00 [entrez]
PHST- 2010/06/24 06:00 [pubmed]
PHST- 2010/07/14 06:00 [medline]
AID - DMCN3688 [pii]
AID - 10.1111/j.1469-8749.2010.03688.x [doi]
PST - ppublish
SO  - Dev Med Child Neurol. 2010 Jun;52(6):501. doi: 10.1111/j.1469-8749.2010.03688.x.


PMID- 20569189
OWN - NLM
STAT- MEDLINE
DCOM- 20101130
LR  - 20151119
IS  - 1743-8942 (Electronic)
IS  - 0167-482X (Linking)
VI  - 31
IP  - 3
DP  - 2010 Sep
TI  - Human infertility: is medical treatment enough? A cross-sectional study of a
      sample of Italian couples.
PG  - 158-67
LID - 10.3109/0167482X.2010.487952 [doi]
AB  - OBJECTIVE: To explore infertile couples' well-being, needs and drop-out rates
      considering their previous gynaecological history, treatments and support
      received. METHODS: Self-reported questionnaires and a telephone follow-up were
      used to gather data from a sample of 57 Italian couples undergoing first-step
      procedures for infertility treatment. The questions concerned socio-demographic
      and personality factors, global perspective on generation, childbearing
      motivation, intra-psychic and relational dimensions. RESULTS: The study found a
      strong need for psychological and ethical counselling and showed that drop-out
      rates were related to psychological discontent. Among couples who had a longer
      history of infertility, those who had no previous treatments presented higher
      dyadic adjustment than those who had an history of previous treatments. Moreover,
      the study provides evidences of the stronger need for personal support for
      couples who had undergone previous treatments, and for psychological and ethical 
      support for couples with previous generative failures. It also showed that there 
      were beneficial effects to attending to couples' religious and ethical needs.
      CONCLUSION: Professional care for those who are undergoing or have undergone
      fertility treatment should (i) embrace a broader and more comprehensive
      perspective to understand infertile couples' experience and should (ii) provide
      appropriate therapy to cope with these experiences.
FAU - Sina, Manuela
AU  - Sina M
AD  - UCSC, Bioethics, Rome, Italy. manuela.sina@gmail.com
FAU - Ter Meulen, Ruud
AU  - Ter Meulen R
FAU - Carrasco de Paula, Ignacio
AU  - Carrasco de Paula I
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Psychosom Obstet Gynaecol
JT  - Journal of psychosomatic obstetrics and gynaecology
JID - 8308648
SB  - IM
MH  - Adaptation, Psychological
MH  - Chi-Square Distribution
MH  - Counseling
MH  - Cross-Sectional Studies
MH  - Family Characteristics
MH  - Female
MH  - *Health Services Needs and Demand
MH  - Humans
MH  - Infertility/*psychology/*therapy
MH  - Interviews as Topic
MH  - Italy
MH  - Male
MH  - Patient Satisfaction
MH  - Personality
MH  - Stress, Psychological/psychology/therapy
MH  - Surveys and Questionnaires
EDAT- 2010/06/24 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/06/24 06:00
PHST- 2010/06/24 06:00 [entrez]
PHST- 2010/06/24 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.3109/0167482X.2010.487952 [doi]
PST - ppublish
SO  - J Psychosom Obstet Gynaecol. 2010 Sep;31(3):158-67. doi:
      10.3109/0167482X.2010.487952.


PMID- 20569188
OWN - NLM
STAT- MEDLINE
DCOM- 20101130
LR  - 20100819
IS  - 1743-8942 (Electronic)
IS  - 0167-482X (Linking)
VI  - 31
IP  - 3
DP  - 2010 Sep
TI  - Ethical lapses: staff's perception of abuse in health care.
PG  - 123-9
LID - 10.3109/0167482X.2010.491169 [doi]
AB  - Objective. Studies have shown high lifetime prevalence of abuse in health care
      (AHC) in Nordic gynaecological patients. For patients AHC implies feeling
      disempowered, dehumanised and devalued. The aim of our study was to apprehend
      health care staff's perceptions of AHC. Study design. Qualitative interviews with
      staff at a Swedish gynaecological clinic analysed by Constant comparative
      analysis (N = 21). Results. The two categories - ethical failures against a
      patient and staff members avoid responsibility - gives two disparate pictures of 
      what AHC is. The interviews showed that these pictures can exist alongside even
      if they contradict each other. The core category 'ethical lapses' brings staff's 
      contradictory reflections on AHC together in one picture. Notable is that the
      dualistic notion of AHC did not result in a moral conflict within staff members. 
      Conclusion. Health care staff perceives AHC primarily as ethical lapses. Avoiding
      responsibility for AHC might lead to a failing recognition of AHC, implying that 
      the problem is not properly dealt with. Our study highlights the need for a more 
      open attitude in health care staff toward AHC. To counteract AHC, staff members
      need to accept that AHC occurs also in their own units, bringing in moral
      conflicts in the everyday work.
FAU - Swahnberg, Katarina
AU  - Swahnberg K
AD  - Division of Gender and Medicine, Department of Clinical and Experimental
      Medicine, Faculty of Health Sciences, Linkoping University, Linkoping 581 83,
      Sweden. katarina.swahnberg@liu.se
FAU - Zbikowski, Anke
AU  - Zbikowski A
FAU - Wijma, Barbro
AU  - Wijma B
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Psychosom Obstet Gynaecol
JT  - Journal of psychosomatic obstetrics and gynaecology
JID - 8308648
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Delivery of Health Care/*ethics
MH  - Gynecology/*ethics
MH  - Humans
MH  - Interviews as Topic
MH  - Perception
MH  - Professional-Patient Relations/*ethics
MH  - Sweden
EDAT- 2010/06/24 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/06/24 06:00
PHST- 2010/06/24 06:00 [entrez]
PHST- 2010/06/24 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.3109/0167482X.2010.491169 [doi]
PST - ppublish
SO  - J Psychosom Obstet Gynaecol. 2010 Sep;31(3):123-9. doi:
      10.3109/0167482X.2010.491169.


PMID- 20569151
OWN - NLM
STAT- MEDLINE
DCOM- 20100826
LR  - 20211020
IS  - 1556-2646 (Print)
IS  - 1556-2646 (Linking)
VI  - 5
IP  - 2
DP  - 2010 Jun
TI  - Enhancing HIV vaccine trial consent preparedness among street drug users.
PG  - 65-80
LID - 10.1525/jer.2010.5.2.65 [doi]
AB  - This research used open-ended and true-false questions to assess the preparedness
      of 96 ethnically diverse, economically and socially marginalized adult street
      drug users to consent to participate in HIV vaccine trials (HVT). Specific areas 
      of consent vulnerability included misconceptions about: (1) the recuperative
      value and risk of vaccines in general; (2) the presence of the HIV virus within
      the vaccine and the possibility of contracting or transmitting HIV as a
      consequence of participation; (3) inclusion criteria and experimental blinds; and
      (4) distrust in the medical and research establishments. A brief HVT lesson
      administered to 30 participants was effective in correcting specific HVT
      knowledge misperceptions and increasing certain, but not all areas of HVT trust. 
      Assessment of post-lesson responses to ethics-relevant questions provides
      information on respondents' attitudes toward AIDS safe behavior, research risks
      and benefits, monetary compensation, and willingness to participate. Implications
      for enhancing informed consent for HVT involving active drug users are discussed.
FAU - Fisher, Celia B
AU  - Fisher CB
AD  - Center for Ethics Education and Department of Psychology, Fordham University,
      Dealy Hall, 441 East Fordham Road, Bronx, NY 10458, USA. Fisher@Fordham.edu
LA  - eng
GR  - R01 DA015649/DA/NIDA NIH HHS/United States
GR  - R01 DA015649-01A2/DA/NIDA NIH HHS/United States
GR  - 1 R01 DA015649-01A2/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
RN  - 0 (AIDS Vaccines)
RN  - 0 (Illicit Drugs)
SB  - IM
MH  - *AIDS Vaccines
MH  - Adult
MH  - Clinical Trials as Topic/*ethics
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - *Illicit Drugs
MH  - *Informed Consent/ethics
MH  - Male
MH  - Middle Aged
MH  - *Patient Education as Topic/ethics
MH  - *Patient Selection/ethics
MH  - Risk
MH  - Substance-Related Disorders/*complications
MH  - Trust
MH  - United States
PMC - PMC3133928
MID - NIHMS293882
EDAT- 2010/06/24 06:00
MHDA- 2010/08/27 06:00
CRDT- 2010/06/24 06:00
PHST- 2010/06/24 06:00 [entrez]
PHST- 2010/06/24 06:00 [pubmed]
PHST- 2010/08/27 06:00 [medline]
AID - 10.1525/jer.2010.5.2.65 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2010 Jun;5(2):65-80. doi: 10.1525/jer.2010.5.2.65.


PMID- 20569150
OWN - NLM
STAT- MEDLINE
DCOM- 20100826
LR  - 20211020
IS  - 1556-2646 (Print)
IS  - 1556-2646 (Linking)
VI  - 5
IP  - 2
DP  - 2010 Jun
TI  - Parental permission and perceived research benefits in adolescent STI research.
PG  - 57-64
LID - 10.1525/jer.2010.5.2.57 [doi]
AB  - An understanding of why parents provide consent for adolescent participation in
      research on sensitive topics can inform and improve the ethical conduct and
      review of such research. As part of a longitudinal study of sexually transmitted 
      infections (STIs) in lower-income adolescents, we asked 134 parents why they
      permitted their daughter to participate, analyzing responses using qualitative
      methods. Over half described participation benefits, providing reasons such as
      the study being generally good for their daughters, sex education, someone to
      talk to, and STI testing. Other reasons included positive interactions and
      familiarity with research and clinical staff, friend or family member
      participation, and adolescent autonomy in making the decision to participate. If 
      parents perceived their daughter to be "at risk" in some way, such as for STI or 
      pregnancy, they were more likely to cite participation benefits. These data can
      be used to make such research more sensitive to family and community needs.
FAU - Ott, Mary A
AU  - Ott MA
AD  - Section of Adolescent Medicine, Department of Pediatrics, Indiana University
      School of Medicine, 410 West 10th Street, HS 1001, Indianapolis, IN 46202, USA.
      maott@iupui.edu
FAU - Rosenberger, Joshua G
AU  - Rosenberger JG
FAU - Fortenberry, J Dennis
AU  - Fortenberry JD
LA  - eng
GR  - K23 HD049444/HD/NICHD NIH HHS/United States
GR  - K23-HD049444-01A2/HD/NICHD NIH HHS/United States
GR  - K23 HD049444-01A1/HD/NICHD NIH HHS/United States
GR  - U19 AI031494-15/AI/NIAID NIH HHS/United States
GR  - U19 AI031494/AI/NIAID NIH HHS/United States
GR  - L40 HD048359/HD/NICHD NIH HHS/United States
GR  - R01 HD 044387/HD/NICHD NIH HHS/United States
GR  - R01 HD044387/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Attitude to Health
MH  - *Behavioral Research/ethics
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - *Parental Consent/ethics
MH  - Parents/psychology
MH  - *Patient Selection/ethics
MH  - Qualitative Research
MH  - Sexually Transmitted Diseases/*prevention & control
MH  - United States
PMC - PMC3113634
MID - NIHMS293878
EDAT- 2010/06/24 06:00
MHDA- 2010/08/27 06:00
CRDT- 2010/06/24 06:00
PHST- 2010/06/24 06:00 [entrez]
PHST- 2010/06/24 06:00 [pubmed]
PHST- 2010/08/27 06:00 [medline]
AID - 10.1525/jer.2010.5.2.57 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2010 Jun;5(2):57-64. doi: 10.1525/jer.2010.5.2.57.


PMID- 20569148
OWN - NLM
STAT- MEDLINE
DCOM- 20100826
LR  - 20100623
IS  - 1556-2646 (Print)
IS  - 1556-2646 (Linking)
VI  - 5
IP  - 2
DP  - 2010 Jun
TI  - Are we asking the right questions? A review of Canadian REB practices in relation
      to community-based participatory research.
PG  - 35-46
LID - 10.1525/jer.2010.5.2.35 [doi]
AB  - Access barriers to effective ethics review continue to be a significant challenge
      for researchers and community-based organizations undertaking community-based
      participatory research (CBPR). This article reports on findings from a content
      analysis of select (Behavioural, Biomedical, Social Sciences, Humanities)
      research ethics boards (REBs) in the Canadian research context (n = 86). Existing
      ethics review documentation was evaluated using 30 CBPR related criteria for
      their sensitivity to relevant approaches, processes, and outcomes. A linear
      regression was conducted to determine whether specific organizational
      characteristics have an impact on the CBPR sensitivity: (1) region of Canada, (2)
      type of institution (university or a healthcare organization), (3) primary
      institutional language (English or French) and (4) national ranking with respect 
      to research intensiveness. While only research intensiveness proved statistically
      significant (p = .001), we recognize REB protocol forms may not actually reflect 
      how CBPR is reviewed. Despite using a single guiding ethical framework, REBs
      across Canada employ a variety of techniques to review research studies. We
      report on these differences and varying levels of sensitivity to CBPR. Finally,
      we highlight best practices and make recommendations for integrating CBPR
      principles into existing ethics review.
FAU - Guta, Adrian
AU  - Guta A
AD  - University of Toronto, Toronto, Ontario, Canada. adrian.guta@utoronto.ca
FAU - Wilson, Michael G
AU  - Wilson MG
FAU - Flicker, Sarah
AU  - Flicker S
FAU - Travers, Robb
AU  - Travers R
FAU - Mason, Catherine
AU  - Mason C
FAU - Wenyeve, Gloria
AU  - Wenyeve G
FAU - O'Campo, Patricia
AU  - O'Campo P
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Benchmarking
MH  - Canada
MH  - Community-Based Participatory Research/*ethics
MH  - Cross-Sectional Studies
MH  - *Ethics Committees, Research
MH  - Humans
MH  - Linear Models
EDAT- 2010/06/24 06:00
MHDA- 2010/08/27 06:00
CRDT- 2010/06/24 06:00
PHST- 2010/06/24 06:00 [entrez]
PHST- 2010/06/24 06:00 [pubmed]
PHST- 2010/08/27 06:00 [medline]
AID - 10.1525/jer.2010.5.2.35 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2010 Jun;5(2):35-46. doi: 10.1525/jer.2010.5.2.35.


PMID- 20569147
OWN - NLM
STAT- MEDLINE
DCOM- 20100826
LR  - 20100623
IS  - 1556-2646 (Print)
IS  - 1556-2646 (Linking)
VI  - 5
IP  - 2
DP  - 2010 Jun
TI  - Resources employed by health researchers to ensure ethical research practice.
PG  - 21-34
LID - 10.1525/jer.2010.5.2.21 [doi]
AB  - There is little empirical evidence about what resources health researchers use in
      order to make decisions about the ethical conduct of human research. Undertaking 
      an empirical examination of how researchers understand research ethics and how
      they address ethical issues in research practice can lead to a richer
      understanding of how researchers approach research ethics. Our findings are based
      on interviews with 54 Australian health researchers. We conclude that, despite
      the considerable time devoted to ethics review, ethics committees and research
      guidelines were not seen as valuable resources for researchers undertaking
      research in the field. Although researchers did not perceive ethics committees as
      a resource when faced with ethical issues in the field, they nevertheless
      perceived the process of ethics review as beneficial to them; this allowed them
      to clarify their research, make decisions about the ethical conduct of the
      research, as well as offering them a sense of protection when undertaking
      research. In the actual undertaking of research practice, it was their past
      professional experience and personal values that researchers considered most
      useful resources when encountering ethical problems.
FAU - Guillemin, Marilys
AU  - Guillemin M
AD  - Centre for Health and Society, School of Population Health, University of
      Melbourne, Victoria 2010, Australia. m.guillemin@unimelb.edu.au
FAU - Gillam, Lynn
AU  - Gillam L
FAU - Rosenthal, Doreen
AU  - Rosenthal D
FAU - Bolitho, Annie
AU  - Bolitho A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - *Attitude
MH  - Benchmarking
MH  - Decision Making/*ethics
MH  - *Ethics Committees, Research
MH  - *Ethics, Research
MH  - Guidelines as Topic
MH  - Humans
MH  - *Interprofessional Relations
MH  - *Research Personnel
MH  - Victoria
EDAT- 2010/06/24 06:00
MHDA- 2010/08/27 06:00
CRDT- 2010/06/24 06:00
PHST- 2010/06/24 06:00 [entrez]
PHST- 2010/06/24 06:00 [pubmed]
PHST- 2010/08/27 06:00 [medline]
AID - 10.1525/jer.2010.5.2.21 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2010 Jun;5(2):21-34. doi: 10.1525/jer.2010.5.2.21.


PMID- 20569146
OWN - NLM
STAT- MEDLINE
DCOM- 20100826
LR  - 20151119
IS  - 1556-2646 (Print)
IS  - 1556-2646 (Linking)
VI  - 5
IP  - 2
DP  - 2010 Jun
TI  - The exploitation of "Exploitation" in the tenofovir prep trial in Cameroon:
      Lessons learned from media coverage of an HIV prevention trial.
PG  - 3-19
LID - 10.1525/jer.2010.5.2.3 [doi]
AB  - media coverage influences how clinical trials are perceived internationally and
      in communities where trials occur, affecting recruitment, retention, and
      political support for research. We conducted a discourse analysis of news
      coverage from 2004-2005 of a trial in Cameroon on oral PrEP for HIV prevention,
      to identify messages, communication techniques, and sources of messages that were
      amplified via media. We identified two parallel discourses: one on ethical
      concerns about the Cameroon trial, and a second, more general "science
      exploitation" discourse concerned with the potential for trials with vulnerable
      participant populations to be conducted unethically, benefiting only wealthy
      populations. Researchers should overtly address exploitation as an integral,
      ongoing component of research, particularly where historical or cultural
      conditions set the stage for controversy to emerge.
FAU - Mack, Natasha
AU  - Mack N
AD  - Family Health International, P.O. Box 13950, Research Triangle Park, NC 27709,
      USA. nmack@fhi.org
FAU - Robinson, Elizabeth T
AU  - Robinson ET
FAU - MacQueen, Kathleen M
AU  - MacQueen KM
FAU - Moffett, Jill
AU  - Moffett J
FAU - Johnson, Laura M
AU  - Johnson LM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
RN  - 0 (Anti-HIV Agents)
RN  - 0 (Organophosphonates)
RN  - 99YXE507IL (Tenofovir)
RN  - JAC85A2161 (Adenine)
SB  - IM
MH  - Adenine/*analogs & derivatives/therapeutic use
MH  - Anti-HIV Agents/*therapeutic use
MH  - Cameroon
MH  - *Ethics, Research
MH  - Female
MH  - HIV Infections/*prevention & control
MH  - *Human Rights
MH  - Humans
MH  - Internationality
MH  - *Mass Media
MH  - Organophosphonates/*therapeutic use
MH  - Persuasive Communication
MH  - Problem Solving
MH  - *Public Relations
MH  - Randomized Controlled Trials as Topic/*ethics
MH  - Tenofovir
MH  - Vulnerable Populations
EDAT- 2010/06/24 06:00
MHDA- 2010/08/27 06:00
CRDT- 2010/06/24 06:00
PHST- 2010/06/24 06:00 [entrez]
PHST- 2010/06/24 06:00 [pubmed]
PHST- 2010/08/27 06:00 [medline]
AID - 10.1525/jer.2010.5.2.3 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2010 Jun;5(2):3-19. doi: 10.1525/jer.2010.5.2.3.


PMID- 20569145
OWN - NLM
STAT- MEDLINE
DCOM- 20100826
LR  - 20100623
IS  - 1556-2646 (Print)
IS  - 1556-2646 (Linking)
VI  - 5
IP  - 2
DP  - 2010 Jun
TI  - Stages of evidence-based ethical problem-solving in human research.
PG  - 1-2
LID - 10.1525/jer.2010.5.2.1 [doi]
FAU - Sieber, Joan E
AU  - Sieber JE
LA  - eng
PT  - Editorial
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Ethics, Research
MH  - *Evidence-Based Practice
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - *Problem Solving
EDAT- 2010/06/24 06:00
MHDA- 2010/08/27 06:00
CRDT- 2010/06/24 06:00
PHST- 2010/06/24 06:00 [entrez]
PHST- 2010/06/24 06:00 [pubmed]
PHST- 2010/08/27 06:00 [medline]
AID - 10.1525/jer.2010.5.2.1 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2010 Jun;5(2):1-2. doi: 10.1525/jer.2010.5.2.1.


PMID- 20569054
OWN - NLM
STAT- MEDLINE
DCOM- 20101227
LR  - 20100623
IS  - 1557-850X (Electronic)
IS  - 1538-7135 (Linking)
VI  - 8
IP  - 2
DP  - 2010 Jun
TI  - Healthcare system cost evaluation of antiviral stockpiling for pandemic influenza
      preparedness.
PG  - 119-28
LID - 10.1089/bsp.2009.0050 [doi]
AB  - Healthcare workers need to be protected during a severe influenza outbreak;
      therefore, we evaluated 4 different antiviral strategies: (1) using antiviral
      medication for outbreak prophylaxis of all hospital employees; (2) using
      antiviral medication for postexposure prophylaxis (PEP) or treatment of all
      hospital employees; (3) using a combination of antiviral medication for outbreak 
      prophylaxis of high-risk clinical staff and postexposure prophylaxis or treatment
      for all other staff; and (4) using antiviral medication for postexposure
      prophylaxis or treatment of high-risk clinical staff only. Three different
      purchasing options were applied to each of the 4 antiviral strategies: (1)
      just-in-time purchase during a severe influenza outbreak, (2) prepandemic
      stockpiling, or (3) stockpiling through contracts with pharmaceutical
      manufacturers to reserve a predetermined antiviral supply. Although outbreak
      prophylaxis of all hospital employees would offer the maximum protection, the
      large costs associated with such a purchase make this option unrealistic and
      impractical. In addition, even though postexposure prophylaxis or treatment of
      only high-risk clinical staff would incur the least expense, the assumed level of
      protection if these options were offered only to high-risk clinical staff may not
      be sufficient to maintain routine hospital operations, since needed non-high-risk
      staff would not be protected. Considering the potential benefits and drawbacks of
      stockpiling antiviral medication from a cost perspective, it does not appear
      feasible for hospitals to stockpile antiviral medication in large quantities
      prior to a severe influenza outbreak. This article focuses on the financial
      viability of stockpiling antiviral medication, but the potential impact of other 
      factors on the decision to stockpile was also considered and will be explored in 
      future analyses. While legal hurdles related to prescribing, storing, and
      dispensing antiviral medication can be addressed, unavailability of a suitable
      vaccine supply may strongly support a decision to stockpile antiviral medication.
      Other issues to be addressed include antiviral resistance specifically related to
      the efficacy of oseltamivir, coupled with a high frequency of secondary bacterial
      infections; uncertainties about the degree of government assistance; potential
      government seizures of stockpiled assets; and legal and ethical concerns related 
      to fair access to stockpiled medication. These issues may all be perceived as
      barriers to the feasibility of stockpiling antiviral medication.
FAU - Li, Yang
AU  - Li Y
AD  - Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
      yali@jhsph.edu
FAU - Hsu, Edbert B
AU  - Hsu EB
FAU - Links, Jonathan M
AU  - Links JM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Biosecur Bioterror
JT  - Biosecurity and bioterrorism : biodefense strategy, practice, and science
JID - 101156085
RN  - 0 (Antiviral Agents)
SB  - IM
MH  - Antiviral Agents/*economics
MH  - Costs and Cost Analysis
MH  - Health Personnel
MH  - Hospital Costs
MH  - Humans
MH  - Influenza, Human/*epidemiology
MH  - Occupational Health Services/economics
MH  - Pandemics/*prevention & control
MH  - Post-Exposure Prophylaxis/economics
MH  - Primary Prevention/economics
MH  - United States/epidemiology
EDAT- 2010/06/24 06:00
MHDA- 2010/12/28 06:00
CRDT- 2010/06/24 06:00
PHST- 2010/06/24 06:00 [entrez]
PHST- 2010/06/24 06:00 [pubmed]
PHST- 2010/12/28 06:00 [medline]
AID - 10.1089/bsp.2009.0050 [doi]
PST - ppublish
SO  - Biosecur Bioterror. 2010 Jun;8(2):119-28. doi: 10.1089/bsp.2009.0050.


PMID- 20568942
OWN - NLM
STAT- MEDLINE
DCOM- 20100913
LR  - 20141116
IS  - 1092-0684 (Electronic)
IS  - 1092-0684 (Linking)
VI  - 28
IP  - 5
DP  - 2010 May
TI  - Brain-computer interfaces: military, neurosurgical, and ethical perspective.
PG  - E25
LID - 10.3171/2010.2.FOCUS1027 [doi]
AB  - Brain-computer interfaces (BCIs) are devices that acquire and transform neural
      signals into actions intended by the user. These devices have been a rapidly
      developing area of research over the past 2 decades, and the military has made
      significant contributions to these efforts. Presently, BCIs can provide humans
      with rudimentary control over computer systems and robotic devices. Continued
      advances in BCI technology are especially pertinent in the military setting,
      given the potential for therapeutic applications to restore function after combat
      injury, and for the evolving use of BCI devices in military operations and
      performance enhancement. Neurosurgeons will play a central role in the further
      development and implementation of BCIs, but they will also have to navigate
      important ethical questions in the translation of this highly promising
      technology. In the following commentary the authors discuss realistic
      expectations for BCI use in the military and underscore the intersection of the
      neurosurgeon's civic and clinical duty to care for those who serve their country.
FAU - Kotchetkov, Ivan S
AU  - Kotchetkov IS
AD  - Department of Neurological Surgery, Columbia University College of Physicians and
      Surgeons, New York, New York, USA.
FAU - Hwang, Brian Y
AU  - Hwang BY
FAU - Appelboom, Geoffrey
AU  - Appelboom G
FAU - Kellner, Christopher P
AU  - Kellner CP
FAU - Connolly, E Sander Jr
AU  - Connolly ES Jr
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neurosurg Focus
JT  - Neurosurgical focus
JID - 100896471
SB  - IM
MH  - Adult
MH  - Animals
MH  - Brain/*physiology
MH  - Communication Aids for Disabled/trends
MH  - Electrodes, Implanted
MH  - Electroencephalography/instrumentation/methods
MH  - Ethics, Professional
MH  - Forecasting
MH  - Humans
MH  - Macaca mulatta
MH  - Man-Machine Systems
MH  - Military Medicine/instrumentation/*methods
MH  - Neurosurgery/ethics/*instrumentation/methods
MH  - *Self-Help Devices
MH  - *User-Computer Interface
EDAT- 2010/06/24 06:00
MHDA- 2010/09/14 06:00
CRDT- 2010/06/24 06:00
PHST- 2010/06/24 06:00 [entrez]
PHST- 2010/06/24 06:00 [pubmed]
PHST- 2010/09/14 06:00 [medline]
AID - 10.3171/2010.2.FOCUS1027 [doi]
PST - ppublish
SO  - Neurosurg Focus. 2010 May;28(5):E25. doi: 10.3171/2010.2.FOCUS1027.


PMID- 20568444
OWN - NLM
STAT- MEDLINE
DCOM- 20100817
LR  - 20100623
IS  - 0255-2930 (Print)
IS  - 0255-2930 (Linking)
VI  - 30
IP  - 4
DP  - 2010 Apr
TI  - [Biography of the outstanding acupuncturist Xie Xi-Liang].
PG  - 337-40
AB  - Xie Xi-Liang is an outstanding acupuncturist and doctor of TCM in Shanxi
      province. He is an immediate disciple of the prominent acupuncturist Cheng
      Dan-An. Furthermore, he is an important representative of Cheng-jiang school. He 
      promotes and improves the technique of direct moxibustion; he has served the
      public by offering simple and effective acupuncture treatment for many years. His
      way of training is unique which emphasizes the importance of medical ethics and
      basic skill in acupuncture. He organizes multiple acupuncture training classes
      that have trained a great number of acupuncturists. He has great learing and rich
      practical experiences; he contributes tremendously in promoting moxibustion and
      the basic skill in acupuncture.
FAU - Guan, Ling
AU  - Guan L
AD  - Department of Acupuncture and Moxibustion, General Hospital of PLA, Beijing
      100853, China. guanling301@sina.com
FAU - Ji, Lai-Xi
AU  - Ji LX
LA  - chi
PT  - Biography
PT  - English Abstract
PT  - Historical Article
PT  - Journal Article
PL  - China
TA  - Zhongguo Zhen Jiu
JT  - Zhongguo zhen jiu = Chinese acupuncture & moxibustion
JID - 8600658
SB  - IM
MH  - Acupuncture/*history
MH  - *Acupuncture Therapy
MH  - China
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Male
PS  - Xie XL
FPS - Xie, Xi-Liang
EDAT- 2010/06/24 06:00
MHDA- 2010/08/18 06:00
CRDT- 2010/06/24 06:00
PHST- 2010/06/24 06:00 [entrez]
PHST- 2010/06/24 06:00 [pubmed]
PHST- 2010/08/18 06:00 [medline]
PST - ppublish
SO  - Zhongguo Zhen Jiu. 2010 Apr;30(4):337-40.


PMID- 27732531
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1472-0795 (Print)
IS  - 1472-0795 (Linking)
VI  - 22
IP  - 6
DP  - 2010 Jun 24
TI  - Endoscopic gastrostomy.
PG  - 13
AB  - Percutaneous endoscopic gastrostomy involves placing a feeding tube directly in
      the stomach through a small incision in the abdominal wall. Feeding in this way
      presents moral and ethical problems and should only be considered where there are
      likely to be improvements in quality of life.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Older People
JT  - Nursing older people
JID - 101084156
EDAT- 2010/06/24 00:00
MHDA- 2010/06/24 00:01
CRDT- 2016/10/13 06:00
PHST- 2016/10/13 06:00 [entrez]
PHST- 2010/06/24 00:00 [pubmed]
PHST- 2010/06/24 00:01 [medline]
AID - 10.7748/nop.22.6.13.s22 [doi]
PST - ppublish
SO  - Nurs Older People. 2010 Jun 24;22(6):13. doi: 10.7748/nop.22.6.13.s22.


PMID- 20567932
OWN - NLM
STAT- MEDLINE
DCOM- 20110701
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 16
IP  - 4
DP  - 2010 Dec
TI  - Avoiding twisted pixels: ethical guidelines for the appropriate use and
      manipulation of scientific digital images.
PG  - 639-67
LID - 10.1007/s11948-010-9201-y [doi]
AB  - Digital imaging has provided scientists with new opportunities to acquire and
      manipulate data using techniques that were difficult or impossible to employ in
      the past. Because digital images are easier to manipulate than film images, new
      problems have emerged. One growing concern in the scientific community is that
      digital images are not being handled with sufficient care. The problem is
      twofold: (1) the very small, yet troubling, number of intentional falsifications 
      that have been identified, and (2) the more common unintentional, inappropriate
      manipulation of images for publication. Journals and professional societies have 
      begun to address the issue with specific digital imaging guidelines.
      Unfortunately, the guidelines provided often do not come with instructions to
      explain their importance. Thus they deal with what should or should not be done, 
      but not the associated 'why' that is required for understanding the rules. This
      article proposes 12 guidelines for scientific digital image manipulation and
      discusses the technical reasons behind these guidelines. These guidelines can be 
      incorporated into lab meetings and graduate student training in order to provoke 
      discussion and begin to bring an end to the culture of "data beautification".
FAU - Cromey, Douglas W
AU  - Cromey DW
AD  - Department of Cell Biology and Anatomy, University of Arizona College of
      Medicine, 1501 N. Campbell Ave., Tucson, AZ 85724-5044, USA.
      dcromey@email.arizona.edu
LA  - eng
GR  - P30 ES006694/ES/NIEHS NIH HHS/United States
GR  - ES006694/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20100622
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
CIN - Sci Eng Ethics. 2010 Dec;16(4):669-73. PMID: 20730569
MH  - Codes of Ethics
MH  - Data Compression/ethics
MH  - *Ethics, Research
MH  - *Guidelines as Topic
MH  - Image Processing, Computer-Assisted/*ethics
MH  - Photography/*ethics
MH  - Science/*ethics
MH  - Scientific Misconduct
PMC - PMC4114110
MID - NIHMS575182
EDAT- 2010/06/23 06:00
MHDA- 2011/07/02 06:00
CRDT- 2010/06/23 06:00
PHST- 2007/02/14 00:00 [received]
PHST- 2009/07/21 00:00 [accepted]
PHST- 2010/06/23 06:00 [entrez]
PHST- 2010/06/23 06:00 [pubmed]
PHST- 2011/07/02 06:00 [medline]
AID - 10.1007/s11948-010-9201-y [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2010 Dec;16(4):639-67. doi: 10.1007/s11948-010-9201-y. Epub 2010 
      Jun 22.


PMID- 20567617
OWN - NLM
STAT- MEDLINE
DCOM- 20100915
LR  - 20211020
IS  - 1449-1907 (Electronic)
IS  - 1449-1907 (Linking)
VI  - 7
IP  - 3
DP  - 2010 Jun 3
TI  - CEO- CNE relationships: building an evidence-base of chief nursing executive
      replacement costs.
PG  - 160-8
AB  - OBJECTIVE: Explore professional relationships between Chief Nurse Executives
      (CNEs) and Chief Executive Officers (CEOs); CNE ethnic diversity; and CNE
      replacement costs. BACKGROUND: Theoretical frameworks - Marilyn Ray's Theory of
      Bureaucratic Caring, and Turkel's Theory of Relational Complexity espousing
      economic as well as caring variables. METHODS: Exploratory mixed-method
      descriptive design using CNE mailed survey. RESULTS: CNE- cited opportunities for
      maintaining a positive relationship with the CEO: respect for CEO; goal- sharing 
      (r=.782, p<0.01); having a strong relationship (r= .718, p<0.01);
      co-problem-solving (r=.437, p<0.01); having an interesting job (r=.406, p<0.01); 
      having similar interests with CEO (r= .346, p<0.01); CEO and CNE maintaining
      specific roles (r= .261, p<0.05); satisfaction with CNE income (r=.251, p<0.05); 
      willingness to improve relationship with CEO (r=.254, p<0.05). CNE positions
      demonstrated an ethnic diversity factor of 0.03%. CNE replacement costs to
      healthcare facilities were over 1.5 million dollars. CONCLUSION: CNE/CEO
      relationships have identified cohesive factors that may contribute to CNE
      longevity in position; an ethically diverse CNE deficit exists; and, CNE turnover
      and vacancy rates impact an organization's financial health and quality of care.
FAU - Sredl, Darlene
AU  - Sredl D
AD  - University of Missouri at St. Louis, St. Louis, MO 63005, USA. sredld@umsl.edu
FAU - Peng, Niang-Huei
AU  - Peng NH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100603
PL  - Australia
TA  - Int J Med Sci
JT  - International journal of medical sciences
JID - 101213954
SB  - IM
MH  - Chief Executive Officers, Hospital/*economics
MH  - Nurse Administrators/*economics
MH  - Personnel Turnover/*economics
PMC - PMC2887056
OTO - NOTNLM
OT  - Chief Executive Officer
OT  - Chief Nurse Executive
OT  - Nurse
OT  - replacement costs
EDAT- 2010/06/23 06:00
MHDA- 2010/09/16 06:00
CRDT- 2010/06/23 06:00
PHST- 2009/08/26 00:00 [received]
PHST- 2010/05/26 00:00 [accepted]
PHST- 2010/06/23 06:00 [entrez]
PHST- 2010/06/23 06:00 [pubmed]
PHST- 2010/09/16 06:00 [medline]
AID - 10.7150/ijms.7.160 [doi]
PST - epublish
SO  - Int J Med Sci. 2010 Jun 3;7(3):160-8. doi: 10.7150/ijms.7.160.


PMID- 20567073
OWN - NLM
STAT- MEDLINE
DCOM- 20101124
LR  - 20190201
IS  - 2384-8553 (Electronic)
IS  - 0021-2571 (Linking)
VI  - 46
IP  - 2
DP  - 2010
TI  - Personalism for public health ethics.
PG  - 204-9
LID - 10.4415/ANN_10_02_15 [doi]
AB  - In public health ethics, as in bioethics, utilitarian approaches usually prevail,
      followed by Kantian and communitarian foundations. If one considers the nature
      and core functions of public health, which are focused on a population
      perspective, utilitarianism seems still more applicable to public health ethics. 
      Nevertheless, faulting additional protections towards the human person,
      utilitarianism doesn't offer appropriate solutions when conflicts among values do
      arise. Further criteria must be applied to protect the fundamental principles of 
      respect for human life. Personalism offers similar advantages to utilitarianism
      but warrants more protection to the human person. We suggest a possible
      adaptation of personalism in the specific field of public health by means of four
      principles: absolute respect for life or principle of inviolability; subsidiarity
      and the "minimum" mandatory principle; solidarity; justice and non
      discrimination.
FAU - Petrini, Carlo
AU  - Petrini C
AD  - Unita di Bioetica, Presidenza, Istituto Superiore di Sanita, Rome, Italy.
      carlo.petrini@iss.it
FAU - Gainotti, Sabina
AU  - Gainotti S
FAU - Requena, Pablo
AU  - Requena P
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Ann Ist Super Sanita
JT  - Annali dell'Istituto superiore di sanita
JID - 7502520
SB  - IM
MH  - Bioethical Issues
MH  - Humans
MH  - *Personhood
MH  - Public Health/*ethics
EDAT- 2010/06/23 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/06/23 06:00
PHST- 2010/06/23 06:00 [entrez]
PHST- 2010/06/23 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.4415/ANN_10_02_15 [doi]
PST - ppublish
SO  - Ann Ist Super Sanita. 2010;46(2):204-9. doi: 10.4415/ANN_10_02_15.


PMID- 20566379
OWN - NLM
STAT- MEDLINE
DCOM- 20110131
LR  - 20101005
IS  - 1873-488X (Electronic)
IS  - 1056-8719 (Linking)
VI  - 62
IP  - 3
DP  - 2010 Nov-Dec
TI  - Ethical implications of using the minipig in regulatory toxicology studies.
PG  - 160-6
LID - 10.1016/j.vascn.2010.05.002 [doi]
AB  - Two key questions are addressed in this article. What are the potential harms to 
      minipigs relative to the harms for dogs and non-human primates and can these
      harms be reduced more easily in minipigs than in other species? Are there
      potential benefits resulting from the use of minipigs relative to dogs and
      non-human primates? In considering the answers to these questions, we present an 
      ethical framework which was developed taking into account the viewpoint of all
      concerned parties. This ethical matrix provides a framework upon which to
      identify and explore issues raised by the moral imperative to seek a fair
      compromise between the differing needs of different interest groups, which
      includes both the moral agents and the moral patients. The moral agents are the
      different groups of human stakeholders including society at large, regulatory
      bodies, industrialists and animal care staff. The moral patients are the
      laboratory animals, both breeding stock held by the animal supplier, and
      experimental animals in laboratories. In considering these animals it cannot be
      assumed that dogs, monkeys and minipigs differ with regard to the pain and
      suffering that they may experience and undergo when treated in studies designed
      for safety assessment. On this basis we rejected the argument that minipigs are
      more acceptable experimental animals than dogs or monkeys despite the fact that
      their use may prove less offensive to some groups within society at large.
      Species selection must be made on a case-by-case basis where the benefits are
      assessed by weighing the scientific evidence relating to the predictivity of the 
      animal model, against the harm that may accrue to the animals both from the test 
      procedures and their lifetime experience within the laboratory environment.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Webster, John
AU  - Webster J
AD  - Old Sock Cottage, Mudford Sock, Yeovil, Somerset, United Kingdom.
      john.webster@bristol.ac.uk
FAU - Bollen, Peter
AU  - Bollen P
FAU - Grimm, Herwig
AU  - Grimm H
FAU - Jennings, Maggy
AU  - Jennings M
CN  - Steering Group of the RETHINK Project
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100531
PL  - United States
TA  - J Pharmacol Toxicol Methods
JT  - Journal of pharmacological and toxicological methods
JID - 9206091
SB  - IM
MH  - Animal Technicians/psychology
MH  - Animal Use Alternatives/ethics
MH  - Animal Welfare
MH  - Animals
MH  - Animals, Laboratory/physiology
MH  - European Union
MH  - Government Regulation
MH  - Humans
MH  - Models, Animal
MH  - Public Opinion
MH  - Swine
MH  - *Swine, Miniature/physiology
MH  - Toxicity Tests/*ethics/standards
EDAT- 2010/06/23 06:00
MHDA- 2011/02/01 06:00
CRDT- 2010/06/23 06:00
PHST- 2009/12/30 00:00 [received]
PHST- 2010/05/21 00:00 [revised]
PHST- 2010/05/24 00:00 [accepted]
PHST- 2010/06/23 06:00 [entrez]
PHST- 2010/06/23 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
AID - S1056-8719(10)00075-4 [pii]
AID - 10.1016/j.vascn.2010.05.002 [doi]
PST - ppublish
SO  - J Pharmacol Toxicol Methods. 2010 Nov-Dec;62(3):160-6. doi:
      10.1016/j.vascn.2010.05.002. Epub 2010 May 31.


PMID- 20566263
OWN - NLM
STAT- MEDLINE
DCOM- 20110922
LR  - 20191210
IS  - 1873-5134 (Electronic)
IS  - 0738-3991 (Linking)
VI  - 83
IP  - 2
DP  - 2011 May
TI  - Lifestyle, health and the ethics of good living. Health behaviour counselling in 
      general practice.
PG  - 180-4
LID - 10.1016/j.pec.2010.05.022 [doi]
AB  - OBJECTIVE: To present theory that illustrates the relevance of ethics for
      lifestyle counselling in patient-centred general practice, and to illustrate the 
      theory by a qualitative study exploring how doctors may obstruct or enhance the
      possibilities for ethical dialogue. METHODS: The theoretical part is based on
      theory of common morality and Habermas' communication theory. The empirical study
      consists of 12 consultations concerning lifestyle changes, followed by interviews
      of doctors and patients. ANALYSIS: Identification of two contrasting
      consultations holding much and little ethical dialogue, "translation" into speech
      acts, and interpretation of speech acts and interviews guided by theory. RESULTS:
      General advice obstructed possibilities for ethical clarification and
      patient-centredness. Ethical clarification was asked for, and was enhanced by the
      doctor using communication techniques such as interpretation, summarization, and 
      exploration of the objective, subjective and social dimensions of the patients'
      lifeworlds. However, to produce concrete good decisions an additional reflection 
      over possibilities and obstacles in the patient's lifeworld is necessary.
      CONCLUSION: Consultations concerning lifestyle changes hold opportunities for
      ethical clarification and reflection which may create decisions rooted in the
      patient's everyday life. PRACTICE IMPLICATIONS: The study suggests that GPs
      should encourage active reflection and deliberation on values and norms in
      consultations concerning lifestyle changes.
CI  - Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Walseth, Liv Tveit
AU  - Walseth LT
AD  - Research Unit for General Practice, Uni Health, Bergen, Norway. liv@walseth.no
FAU - Abildsnes, Eirik
AU  - Abildsnes E
FAU - Schei, Edvin
AU  - Schei E
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100620
PL  - Ireland
TA  - Patient Educ Couns
JT  - Patient education and counseling
JID - 8406280
MH  - Adult
MH  - Communication
MH  - Directive Counseling/*ethics/methods
MH  - *Ethics, Medical
MH  - Female
MH  - General Practitioners/*ethics
MH  - *Health Behavior
MH  - Health Promotion
MH  - Health Status
MH  - Humans
MH  - Interview, Psychological
MH  - *Life Style
MH  - Male
MH  - Motivation
MH  - Patient Education as Topic/ethics
MH  - Patient-Centered Care/*ethics
MH  - Physician-Patient Relations
MH  - Qualitative Research
EDAT- 2010/06/23 06:00
MHDA- 2011/09/23 06:00
CRDT- 2010/06/23 06:00
PHST- 2009/10/29 00:00 [received]
PHST- 2010/04/12 00:00 [revised]
PHST- 2010/05/25 00:00 [accepted]
PHST- 2010/06/23 06:00 [entrez]
PHST- 2010/06/23 06:00 [pubmed]
PHST- 2011/09/23 06:00 [medline]
AID - S0738-3991(10)00315-0 [pii]
AID - 10.1016/j.pec.2010.05.022 [doi]
PST - ppublish
SO  - Patient Educ Couns. 2011 May;83(2):180-4. doi: 10.1016/j.pec.2010.05.022. Epub
      2010 Jun 20.


PMID- 20566017
OWN - NLM
STAT- MEDLINE
DCOM- 20101029
LR  - 20100622
IS  - 1195-9479 (Print)
IS  - 1195-9479 (Linking)
VI  - 17
IP  - 3
DP  - 2010 Jun
TI  - Use of surgical clips prevents suture slippage when ligating folded vas deferens 
      during vasectomy.
PG  - 5213-5
AB  - OBJECTIVE: We describe a technique of surgical clip placement, which prevents
      slippage when ligating the folded vas deferens during vasectomy. METHODS: We
      utilized this technique in 25 consecutive vasectomy procedures. After isolating
      the vas, two mosquito clamps are placed approximately 2 cm-3 cm apart and a small
      5 mm-10 mm section of full thickness vas is removed. The lumen of each cut end is
      cauterized. Surgical clips (Ethicon Ligaclip Extra LS-200, Medium) are placed at 
      approximately 2 mm, 3 mm and 15 mm (on the opposite side of the hemostat) from
      each cut end. By rotating the hemostat, the vas is folded on itself and a 3-0 or 
      4-0 chromic suture is placed between the two proximal clips and distal to the
      third clip. The hemostat is carefully removed and the vas gently ligated.
      RESULTS: A single surgeon noted no instances of suture slippage in 25 consecutive
      vasectomies. All patients underwent postoperative semen analysis that showed
      azoospermia. CONCLUSION: Placement of the ligating suture between two proximal
      clips and past a third distal clip prevents suture slippage when ligating the
      folded end of the vas deferens during vasectomy.
FAU - Hadj-Moussa, Miriam
AU  - Hadj-Moussa M
AD  - Division of Urology, Medical College of Georgia, Augusta, Georgia, USA.
FAU - Brown, James A
AU  - Brown JA
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can J Urol
JT  - The Canadian journal of urology
JID - 9515842
SB  - IM
CIN - Can J Urol. 2010 Jun;17(3):5215. PMID: 20566018
MH  - Humans
MH  - Ligation
MH  - Male
MH  - Surgical Instruments
MH  - Sutures
MH  - Urologic Surgical Procedures/instrumentation/methods
MH  - Vas Deferens
MH  - Vasectomy/*instrumentation
EDAT- 2010/06/23 06:00
MHDA- 2010/10/30 06:00
CRDT- 2010/06/23 06:00
PHST- 2010/06/23 06:00 [entrez]
PHST- 2010/06/23 06:00 [pubmed]
PHST- 2010/10/30 06:00 [medline]
PST - ppublish
SO  - Can J Urol. 2010 Jun;17(3):5213-5.


PMID- 20566013
OWN - NLM
STAT- MEDLINE
DCOM- 20101029
LR  - 20191210
IS  - 1195-9479 (Print)
IS  - 1195-9479 (Linking)
VI  - 17
IP  - 3
DP  - 2010 Jun
TI  - Validation of electronic urinary incontinence questionnaires.
PG  - 5195-9
AB  - OBJECTIVE: To investigate whether there is any significant difference between the
      electronic and the paper-based version of Urogenital Distress Inventory-6
      questionnaire (UDI-6) and the Incontinence Impact Questionnaire-7 questionnaire
      (IIQ-7). MATERIALS AND METHODS: An electronic questionnaire and clinical tool was
      developed using a combination of open source questionnaire software and custom
      programming that closely replicated the paper version of the UDI-6 and IIQ-7
      questionnaires. Ethics were reviewed and approved by the University Health
      Network of Toronto. The study randomized participants from the Urinary
      Incontinence Clinic to either complete the paper-and-pen version of the
      questionnaires or the electronic version at the beginning of their clinic visit. 
      Sample size was determined to be 50 to sufficiently power the study but due to
      early closing of the clinic only 26 participants could be enrolled in the study. 
      RESULTS AND CONCLUSION: The study found that there was no significant difference 
      (p < .05) between the standardized pen-and-paper and electronic versions of the
      UDI-6 and IIQ-7. The electronic version can be used in place of the paper version
      facilitating physicians understanding and monitoring of the impact of
      incontinence on patients in order to formulate an appropriate treatment plan.
FAU - Straus, Sharon E
AU  - Straus SE
AD  - Department of Medicine, University of Toronto, Li Ka Shing Knowledge Institute at
      St Michael's Hospital, Toronto, Ontario, Canada.
FAU - Holroyd-Leduc, Jayna
AU  - Holroyd-Leduc J
FAU - Orr, Michael Scott
AU  - Orr MS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Validation Study
PL  - Canada
TA  - Can J Urol
JT  - The Canadian journal of urology
JID - 9515842
SB  - IM
MH  - Computers
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Prospective Studies
MH  - *Surveys and Questionnaires
MH  - *Urinary Incontinence
EDAT- 2010/06/23 06:00
MHDA- 2010/10/30 06:00
CRDT- 2010/06/23 06:00
PHST- 2010/06/23 06:00 [entrez]
PHST- 2010/06/23 06:00 [pubmed]
PHST- 2010/10/30 06:00 [medline]
PST - ppublish
SO  - Can J Urol. 2010 Jun;17(3):5195-9.


PMID- 20565831
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20211020
IS  - 1466-609X (Electronic)
IS  - 1364-8535 (Linking)
VI  - 14
IP  - 3
DP  - 2010
TI  - Should fresh blood be recommended for intensive care patients?
PG  - 158
LID - 10.1186/cc9011 [doi]
AB  - Fresh blood has many potential advantages over older blood, but there is no
      evidence that these properties translate into clinical benefit for intensive care
      patients. The observational multicenter study by Karam and colleagues provides
      some evidence suggesting that blood stored for less than 14 days is better than
      older blood in terms of new organ failure and reduction in length of stay in
      pediatric intensive care units. Though in favor of using young blood, this study 
      suffers from several limitations. As a consequence, it is ethical and certainly
      pertinent to conduct a randomized clinical trial in order to test the hypothesis 
      that fresh blood might reduce mortality. The rationale is strong and the
      potential benefit of fresh blood is substantial.
FAU - Guidet, Bertrand
AU  - Guidet B
AD  - Inserm, Unite de Recherche en Epidemiologie Systemes d'Information et
      Modelisation, 184 rue du Faubourg Saint Antoine, 75012 Paris, France.
      bertrand.guidet@sat.aphp.fr
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20100520
PL  - England
TA  - Crit Care
JT  - Critical care (London, England)
JID - 9801902
SB  - IM
CON - Crit Care. 2010;14(2):R57. PMID: 20377853
MH  - Blood Banks
MH  - Blood Transfusion/*methods/mortality
MH  - Critical Illness/*nursing
MH  - Humans
MH  - Multicenter Studies as Topic
MH  - Time Factors
MH  - Transfusion Reaction
PMC - PMC2911714
EDAT- 2010/06/23 06:00
MHDA- 2011/01/07 06:00
CRDT- 2010/06/23 06:00
PHST- 2010/06/23 06:00 [entrez]
PHST- 2010/06/23 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
AID - cc9011 [pii]
AID - 10.1186/cc9011 [doi]
PST - ppublish
SO  - Crit Care. 2010;14(3):158. doi: 10.1186/cc9011. Epub 2010 May 20.


PMID- 20565790
OWN - NLM
STAT- MEDLINE
DCOM- 20101011
LR  - 20211028
IS  - 1471-230X (Electronic)
IS  - 1471-230X (Linking)
VI  - 10
DP  - 2010 Jun 17
TI  - Acupuncture for irritable bowel syndrome: a protocol for a pragmatic randomised
      controlled trial.
PG  - 63
LID - 10.1186/1471-230X-10-63 [doi]
AB  - BACKGROUND: There is insufficient evidence on the effectiveness of acupuncture
      for irritable bowel syndrome (IBS) for conclusions to be drawn. Given the current
      interest in acupuncture by patients, it is in the public interest to establish
      more rigorous evidence. Building on the positive findings from a pilot study, in 
      this paper we present the protocol for a fully-powered trial designed to
      establish whether or not acupuncture is effective and cost-effective.
      METHODS/DESIGN: In this pragmatic randomised controlled trial we will randomise
      patients recruited directly from GP databases to either 10 sessions of
      acupuncture plus usual GP care or to usual GP care alone. The primary clinical
      outcome will be the IBS Symptom Severity Score (SSS) (maximum score 500) at three
      months, and at 12 month assessing whether there is an overall benefit. We
      estimate the sample size required to detect a minimum clinical difference at 90% 
      power and 5% significance to be 188 patients. To allow for loss to follow up we
      will recruit 220 patients drawn from an estimated primary care population of 140 
      000. Analysis will be by intention-to-treat, and multiple imputation is to be
      used for missing data.In a nested qualitative study using in-depth interviews, we
      will explore how patients, acupuncturists, and GPs explain and subsequently
      understand acupuncture to work. We will use purposive sampling to identify
      patients and flexible topic guides for the interviews. The data analysis will
      lead to a thematic description of how patients and practitioners explain how
      acupuncture works, and whether or not the explanations influence treatment
      outcome and/or referrals.We will undertake a cost-effectiveness analysis at 12
      months by comparing resource use in the two groups with any treatment benefit. We
      will use the EQ-5D to measure health-related quality of life and convert into
      quality adjusted life years (QALYs). We will generate cost effectiveness
      acceptability curves (CEACs) exploring the probability that acupuncture will
      produce an acceptable cost per QALY at different cost-effectiveness thresholds.
      DISCUSSION: The trial has received NHS ethics approval and recruited 233 patients
      between November 2008 and June 2009. Results are expected in 2011. TRIAL
      REGISTRATION: Current Controlled Trials ISRCTN08827905.
FAU - MacPherson, Hugh
AU  - MacPherson H
AD  - Department of Health Sciences, University of York, UK. hm18@york.ac.uk
FAU - Bland, Martin
AU  - Bland M
FAU - Bloor, Karen
AU  - Bloor K
FAU - Cox, Helen
AU  - Cox H
FAU - Geddes, David
AU  - Geddes D
FAU - Kang'ombe, Arthur
AU  - Kang'ombe A
FAU - Reynolds, Julie
AU  - Reynolds J
FAU - Stamuli, Eugena
AU  - Stamuli E
FAU - Stuardi, Tracey
AU  - Stuardi T
FAU - Tilbrook, Helen
AU  - Tilbrook H
FAU - Torgerson, David
AU  - Torgerson D
FAU - Whorwell, Peter
AU  - Whorwell P
LA  - eng
SI  - ISRCTN/ISRCTN08827905
GR  - PB-PG-0407-13241/DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20100617
PL  - England
TA  - BMC Gastroenterol
JT  - BMC gastroenterology
JID - 100968547
SB  - IM
MH  - *Acupuncture Therapy/economics
MH  - Cost-Benefit Analysis
MH  - Female
MH  - Humans
MH  - Irritable Bowel Syndrome/economics/*therapy
MH  - Male
MH  - Outcome Assessment, Health Care
MH  - Physicians, Family
MH  - Quality of Life
MH  - Quality-Adjusted Life Years
MH  - Severity of Illness Index
MH  - Treatment Outcome
PMC - PMC2909152
EDAT- 2010/06/23 06:00
MHDA- 2010/10/12 06:00
CRDT- 2010/06/23 06:00
PHST- 2010/02/05 00:00 [received]
PHST- 2010/06/17 00:00 [accepted]
PHST- 2010/06/23 06:00 [entrez]
PHST- 2010/06/23 06:00 [pubmed]
PHST- 2010/10/12 06:00 [medline]
AID - 1471-230X-10-63 [pii]
AID - 10.1186/1471-230X-10-63 [doi]
PST - epublish
SO  - BMC Gastroenterol. 2010 Jun 17;10:63. doi: 10.1186/1471-230X-10-63.


PMID- 20565397
OWN - NLM
STAT- MEDLINE
DCOM- 20100713
LR  - 20220301
IS  - 1365-2044 (Electronic)
IS  - 0003-2409 (Linking)
VI  - 65
IP  - 6
DP  - 2010 Jun
TI  - Ethical issues and donor numbers.
PG  - 646
LID - 10.1111/j.1365-2044.2010.06348.x [doi]
FAU - Iqbal, A
AU  - Iqbal A
AD  - Queen Elizabeth Hospital, Birmingham, UK E-mail: docasimiqbal@msn.com.
FAU - Isaac, J
AU  - Isaac J
AD  - Queen Elizabeth Hospital, Birmingham, UK E-mail: docasimiqbal@msn.com.
FAU - Bramhall, S
AU  - Bramhall S
AD  - Queen Elizabeth Hospital, Birmingham, UK E-mail: docasimiqbal@msn.com.
LA  - eng
PT  - Comment
PT  - Letter
PL  - England
TA  - Anaesthesia
JT  - Anaesthesia
JID - 0370524
SB  - IM
CON - Anaesthesia. 2010 Jan;65(1):84. PMID: 20121777
MH  - Brain Death/*diagnosis
MH  - Ethics, Clinical
MH  - Humans
MH  - Tissue Donors/*ethics
MH  - Tissue and Organ Procurement/*ethics
EDAT- 2010/06/23 06:00
MHDA- 2010/07/14 06:00
CRDT- 2010/06/23 06:00
PHST- 2010/06/23 06:00 [entrez]
PHST- 2010/06/23 06:00 [pubmed]
PHST- 2010/07/14 06:00 [medline]
AID - 10.1111/j.1365-2044.2010.06348.x [doi]
PST - ppublish
SO  - Anaesthesia. 2010 Jun;65(6):646. doi: 10.1111/j.1365-2044.2010.06348.x.


PMID- 20564759
OWN - NLM
STAT- MEDLINE
DCOM- 20101014
LR  - 20220318
IS  - 1471-2865 (Electronic)
IS  - 1358-2267 (Linking)
VI  - 15
IP  - 2
DP  - 2010 Jun
TI  - The ethics of evidence implementation in health care.
PG  - 96-102
LID - 10.1002/pri.479 [doi]
AB  - Evidence based practice is increasingly mandated by all stakeholders as an
      integral process of ensuring safe and quality health care. It is recognised that 
      evidence based practice can contribute to minimising misuse, overuse and underuse
      of health care. Operationalising evidence based practice requires
      physiotherapists to access relevant evidence, appraise the evidence for its
      methodological quality, extract information relevant to their practice, and
      implement it as part of health care service delivery. The final step in this
      process is to evaluate evidence implementation and reflect what, if any, changes 
      to health care processes and outcomes was achieved. From a theoretical
      perspective, these steps seem logical and readily achievable. However, practical 
      application in clinical practice settings has encountered numerous barriers. One 
      such barrier, which is commonly encountered and is a contentious area, is the
      issue of ethics in evidence implementation. Using two hypothetical case studies, 
      we aim to highlight common frustrations encountered by physiotherapists when
      implementing evidence into practice, ethical ambiguity underpinning evidence
      implementation and discuss implications in terms of clinical practice and
      research.
CI  - (c) 2010 John Wiley & Sons, Ltd.
FAU - Kumar, Saravana
AU  - Kumar S
AD  - International Centre for Allied Health Evidence, University of South Australia,
      Adelaide, South Australia, Australia. saravana.kumar@unisa.edu.au
FAU - Grimmer-Somers, Karen
AU  - Grimmer-Somers K
FAU - Hughes, Bernard
AU  - Hughes B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Physiother Res Int
JT  - Physiotherapy research international : the journal for researchers and clinicians
      in physical therapy
JID - 9612022
SB  - IM
MH  - Allied Health Personnel/*ethics
MH  - Evidence-Based Practice/*ethics
MH  - Humans
MH  - Outcome and Process Assessment, Health Care/ethics
MH  - Physical Therapy Modalities/*ethics
MH  - Physical Therapy Specialty/*ethics
EDAT- 2010/06/22 06:00
MHDA- 2010/10/15 06:00
CRDT- 2010/06/22 06:00
PHST- 2010/06/22 06:00 [entrez]
PHST- 2010/06/22 06:00 [pubmed]
PHST- 2010/10/15 06:00 [medline]
AID - 10.1002/pri.479 [doi]
PST - ppublish
SO  - Physiother Res Int. 2010 Jun;15(2):96-102. doi: 10.1002/pri.479.


PMID- 20564758
OWN - NLM
STAT- MEDLINE
DCOM- 20101014
LR  - 20111117
IS  - 1471-2865 (Electronic)
IS  - 1358-2267 (Linking)
VI  - 15
IP  - 2
DP  - 2010 Jun
TI  - Does ethical practice in physiotherapy matter?
PG  - 65-8
LID - 10.1002/pri.480 [doi]
FAU - Partridge, Cecily J
AU  - Partridge CJ
LA  - eng
PT  - Editorial
PT  - Introductory Journal Article
PL  - United States
TA  - Physiother Res Int
JT  - Physiotherapy research international : the journal for researchers and clinicians
      in physical therapy
JID - 9612022
SB  - IM
MH  - Allied Health Personnel/*ethics
MH  - Humans
MH  - Physical Therapy Modalities/*ethics
MH  - Physical Therapy Specialty/*ethics
EDAT- 2010/06/22 06:00
MHDA- 2010/10/15 06:00
CRDT- 2010/06/22 06:00
PHST- 2010/06/22 06:00 [entrez]
PHST- 2010/06/22 06:00 [pubmed]
PHST- 2010/10/15 06:00 [medline]
AID - 10.1002/pri.480 [doi]
PST - ppublish
SO  - Physiother Res Int. 2010 Jun;15(2):65-8. doi: 10.1002/pri.480.


PMID- 20564757
OWN - NLM
STAT- MEDLINE
DCOM- 20101014
LR  - 20220316
IS  - 1471-2865 (Electronic)
IS  - 1358-2267 (Linking)
VI  - 15
IP  - 2
DP  - 2010 Jun
TI  - Beyond a code of ethics: phenomenological ethics for everyday practice.
PG  - 88-95
LID - 10.1002/pri.481 [doi]
AB  - Physical therapy, like all health-care professions, governs itself through a code
      of ethics that defines its obligations of professional behaviours. The code of
      ethics provides professions with a consistent and common moral language and
      principled guidelines for ethical actions. Yet, and as argued in this paper,
      professional codes of ethics have limits applied to ethical decision-making in
      the presence of ethical dilemmas. Part of the limitations of the codes of ethics 
      is that there is no particular hierarchy of principles that govern in all
      situations. Instead, the exigencies of clinical practice, the particularities of 
      individual patient's illness experiences and the transformative nature of chronic
      illnesses and disabilities often obscure the ethical concerns and issues embedded
      in concrete situations. Consistent with models of expert practice, and with
      contemporary models of patient-centred care, we advocate and describe in this
      paper a type of interpretative and narrative approach to moral practice and
      ethical decision-making based on phenomenology. The tools of phenomenology that
      are well defined in research are applied and examined in a case that illustrates 
      their use in uncovering the values and ethical concerns of a patient. Based on
      the deconstruction of this case on a phenomenologist approach, we illustrate how 
      such approaches for ethical understanding can help assist clinicians and
      educators in applying principles within the context and needs of each patient.
CI  - (c) 2010 John Wiley & Sons, Ltd.
FAU - Greenfield, Bruce
AU  - Greenfield B
AD  - Department of Rehabilitation, Division of Physical Therapy, Emory University
      School of Medicine, Center for Ethics Emory University, Atlanta, GA 30322, USA.
      bgreenf@emory.edu
FAU - Jensen, Gail M
AU  - Jensen GM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Physiother Res Int
JT  - Physiotherapy research international : the journal for researchers and clinicians
      in physical therapy
JID - 9612022
SB  - IM
MH  - Allied Health Personnel/*ethics
MH  - *Codes of Ethics
MH  - Decision Making/ethics
MH  - Humans
MH  - Patient Rights
MH  - Personal Autonomy
MH  - Physical Therapy Modalities/*ethics
MH  - Physical Therapy Specialty/*ethics
MH  - Practice Guidelines as Topic
EDAT- 2010/06/22 06:00
MHDA- 2010/10/15 06:00
CRDT- 2010/06/22 06:00
PHST- 2010/06/22 06:00 [entrez]
PHST- 2010/06/22 06:00 [pubmed]
PHST- 2010/10/15 06:00 [medline]
AID - 10.1002/pri.481 [doi]
PST - ppublish
SO  - Physiother Res Int. 2010 Jun;15(2):88-95. doi: 10.1002/pri.481.


PMID- 20564756
OWN - NLM
STAT- MEDLINE
DCOM- 20101014
LR  - 20111117
IS  - 1471-2865 (Electronic)
IS  - 1358-2267 (Linking)
VI  - 15
IP  - 2
DP  - 2010 Jun
TI  - Moral reasoning among physical therapists: results of the Defining Issues Test.
PG  - 69-79
LID - 10.1002/pri.482 [doi]
AB  - BACKGROUND AND PURPOSE: Although there is extensive literature in other health
      care fields about the ability to make ethical judgements (moral reasoning), there
      is a paucity of research addressing the moral reasoning of practising physical
      therapists. The purposes of this research were to 1) identify the types of moral 
      reasoning used by practising physical therapists as measured by the Defining
      Issues Test; 2) identify differences in moral reasoning among physical therapists
      based on educational background, demographic variables, clinical experience,
      practice setting or expertise in ethics; and 3) compare the moral reasoning of
      physical therapists with that of other professional groups. METHODS: The Defining
      Issues Test of James Rest was used to evaluate moral reasoning. Five hundred
      thirty-seven physical therapists responded to a mail survey sent to a random
      sample of 2,000 American Physical Therapy Association members. Twelve physical
      therapists with expertise in ethics or professionalism completed the same survey.
      RESULTS: The mean postconventional score for the random sample was 41.93. This
      score was lower than the mean scores of physicians, nurses, medical students,
      nursing students and dental students established in previous research. Females,
      ethics experts and those in academic settings had higher postconventional scores.
      CONCLUSIONS: Physical therapists scored lower in postconventional moral reasoning
      than some other professional groups with similar educational background. Factors 
      that may inhibit or enhance the development of moral reasoning among physical
      therapists and possible consequences of high or low moral reasoning scores in
      physical therapy require further research. These findings may raise concerns
      about the entry-level educational curriculum and professional development
      opportunities in the area of ethics and moral reasoning. Results of this research
      may also highlight the challenges of evaluation, scholarship and research in
      physical therapy ethics. Further research and theory development is needed to
      address the relationships between moral theory and descriptive or empirical
      research within physical therapy.
CI  - (c) 2010 John Wiley & Sons, Ltd.
FAU - Swisher, Laura Lee
AU  - Swisher LL
AD  - School of Physical Therapy & Rehabilitation Sciences and College of Medicine,
      University of South Florida, Tampa, FL 33612-4766, USA. LSwisher@health.usf.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Physiother Res Int
JT  - Physiotherapy research international : the journal for researchers and clinicians
      in physical therapy
JID - 9612022
SB  - IM
MH  - Allied Health Personnel/*ethics
MH  - Female
MH  - Humans
MH  - Male
MH  - *Moral Development
MH  - Physical Therapy Modalities/*ethics
MH  - Physical Therapy Specialty/*ethics
EDAT- 2010/06/22 06:00
MHDA- 2010/10/15 06:00
CRDT- 2010/06/22 06:00
PHST- 2010/06/22 06:00 [entrez]
PHST- 2010/06/22 06:00 [pubmed]
PHST- 2010/10/15 06:00 [medline]
AID - 10.1002/pri.482 [doi]
PST - ppublish
SO  - Physiother Res Int. 2010 Jun;15(2):69-79. doi: 10.1002/pri.482.


PMID- 20564755
OWN - NLM
STAT- MEDLINE
DCOM- 20101014
LR  - 20220318
IS  - 1471-2865 (Electronic)
IS  - 1358-2267 (Linking)
VI  - 15
IP  - 2
DP  - 2010 Jun
TI  - Addressing conflicts in research ethics: consent and risk of harm.
PG  - 80-7
LID - 10.1002/pri.483 [doi]
AB  - This paper explores some ethical conflicts that may arise in
      physiotherapy-related research, focusing particularly on the issues of informed
      consent and avoidance of harm. These central issues in research ethics are
      defined and related to fundamental moral principles such as respect for autonomy,
      respect for persons and non-maleficence, and their implications are examined
      through a set of hypothetical case studies, encompassing both quantitative and
      qualitative research approaches. It is argued that these ethical requirements may
      legitimately be traded off against each other, so that a prima facie need to gain
      informed consent or to avoid a risk of harm to participants may - within certain 
      limits - be outweighed by other ethical requirements.
CI  - (c) 2010 John Wiley & Sons, Ltd.
FAU - Sim, Julius
AU  - Sim J
AD  - Arthritis Research UK Primary Care Centre, Keele University, Staffordshire, UK.
      j.sim@keele.ac.uk
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Physiother Res Int
JT  - Physiotherapy research international : the journal for researchers and clinicians
      in physical therapy
JID - 9612022
SB  - IM
MH  - *Conflict, Psychological
MH  - *Ethics, Research
MH  - *Harm Reduction
MH  - Human Experimentation/ethics
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Patient Rights/ethics
MH  - Personal Autonomy
MH  - Physical Therapy Modalities/*ethics
MH  - Physical Therapy Specialty/*ethics
MH  - Risk
EDAT- 2010/06/22 06:00
MHDA- 2010/10/15 06:00
CRDT- 2010/06/22 06:00
PHST- 2010/06/22 06:00 [entrez]
PHST- 2010/06/22 06:00 [pubmed]
PHST- 2010/10/15 06:00 [medline]
AID - 10.1002/pri.483 [doi]
PST - ppublish
SO  - Physiother Res Int. 2010 Jun;15(2):80-7. doi: 10.1002/pri.483.


PMID- 20564626
OWN - NLM
STAT- MEDLINE
DCOM- 20100715
LR  - 20220310
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 116
IP  - 13
DP  - 2010 Jul 1
TI  - Informed consent for pediatric phase 1 cancer trials: physicians' perspectives.
PG  - 3244-50
LID - 10.1002/cncr.25158 [doi]
AB  - BACKGROUND: This study was conducted to gather pediatric oncologists' opinions
      about and suggestions for improvement of informed consent (IC) in pediatric phase
      1 cancer trials. METHODS: A questionnaire designed to elicit perspectives was
      distributed to 146 physicians at 6 participating institutions. A total of 103
      completed surveys were returned for a 71% response rate. RESULTS: Pediatric
      oncologists believe providing information so families can decide about phase 1
      study entry is the most important goal of the IC process (ICP). The majority of
      physicians (64%) report that they describe the phase 1 study without any attempt 
      to influence parents' decisions. Several answers provided by physicians were
      associated with their gender and prior IC training. Male physicians were
      significantly more likely to endorse the no-attempt-to-influence approach,
      whereas female physicians were more likely to suggest to parents that other
      children will benefit from what is learned in phase 1 studies. Responses to an
      open-ended question provided 63 suggestions for improvement of the ICP, including
      document and training changes and tools to enhance physician-family
      communication. CONCLUSIONS: Pediatric oncologists tended to present phase 1
      trials as an option rather than a strong recommendation and were reluctant to
      influence decisions of families about these studies. They believe most but not
      all parents understand key concepts involved in consent to this type of research,
      and had ample suggestions for how to improve the ICP. Future research and
      education efforts around this ethically challenging topic were warranted.
FAU - Yap, Tsiao Yi
AU  - Yap TY
AD  - Department of Pediatric Hematology/Oncology, Children's Hospital, Cleveland
      Clinic, Cleveland, Ohio, USA.
FAU - Yamokoski, Amy D
AU  - Yamokoski AD
FAU - Hizlan, Sabahat
AU  - Hizlan S
FAU - Zyzanski, Stephen J
AU  - Zyzanski SJ
FAU - Angiolillo, Anne L
AU  - Angiolillo AL
FAU - Rheingold, Susan R
AU  - Rheingold SR
FAU - Baker, Justin N
AU  - Baker JN
FAU - Kodish, Eric D
AU  - Kodish ED
CN  - Phase I Informed Consent (POIC) Research Team
LA  - eng
GR  - R01 CA122217/CA/NCI NIH HHS/United States
GR  - R01 CA122217-03S1/CA/NCI NIH HHS/United States
GR  - 1R01CA122217/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - *Clinical Trials, Phase I as Topic
MH  - Female
MH  - Health Care Surveys
MH  - Humans
MH  - *Informed Consent
MH  - Male
MH  - *Medical Oncology
MH  - Neoplasms/therapy
MH  - Parental Consent
MH  - *Pediatrics
MH  - Physician's Role
MH  - Physician-Patient Relations
MH  - *Practice Patterns, Physicians'
MH  - Surveys and Questionnaires
PMC - PMC2892009
MID - NIHMS189756
IR  - Mitchum A
FIR - Mitchum, Ariane
EDAT- 2010/06/22 06:00
MHDA- 2010/07/16 06:00
CRDT- 2010/06/22 06:00
PHST- 2010/06/22 06:00 [entrez]
PHST- 2010/06/22 06:00 [pubmed]
PHST- 2010/07/16 06:00 [medline]
AID - 10.1002/cncr.25158 [doi]
PST - ppublish
SO  - Cancer. 2010 Jul 1;116(13):3244-50. doi: 10.1002/cncr.25158.


PMID- 20564474
OWN - NLM
STAT- MEDLINE
DCOM- 20100806
LR  - 20220321
IS  - 1531-4995 (Electronic)
IS  - 0023-852X (Linking)
VI  - 120
IP  - 7
DP  - 2010 Jul
TI  - Balloon dilatation eustachian tuboplasty: a clinical study.
PG  - 1411-6
LID - 10.1002/lary.20950 [doi]
AB  - OBJECTIVES/HYPOTHESIS: To assess the feasibility of balloon dilatation eustachian
      tuboplasty (BET) as an option for treatment of patients with eustachian tube (ET)
      dysfunction. STUDY DESIGN: Ethics approved case controlled interventional study. 
      METHODS: Eight patients were identified with poor ET function using a ET score
      and were assigned to the study. The endoscopic procedure involved the dilatation 
      of the cartilaginous and bony portion of 13 ETs with a balloon catheter. Pre- and
      postinterventional computed tomography was performed. All patients were
      reassessed 1, 2, and 8 weeks after BET. RESULTS: BET was technically easy to
      perform. No damage to essential structures, particularly the carotid canal, was
      found in the human study. Patients revealed a significant improvement of the ET
      score comparing pre- and the 2-month post-treatment results. Improvement was
      found to be time dependent. CONCLUSIONS: This newly introduced method of BET was 
      found to be a feasible and safe procedure to inflate the ET. It significantly
      helped to improve ET function in our study group. However, larger long-term
      studies are necessary to fully evaluate the clinical value of BET.
FAU - Ockermann, Thorsten
AU  - Ockermann T
AD  - Department of Otolaryngology, Head and Neck Surgery, Bielefeld Academic Teaching 
      Hospital, Bielefeld, Germany.
FAU - Reineke, Ulf
AU  - Reineke U
FAU - Upile, Tahwinder
AU  - Upile T
FAU - Ebmeyer, Jorg
AU  - Ebmeyer J
FAU - Sudhoff, Holger H
AU  - Sudhoff HH
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
SB  - IM
CIN - Laryngoscope. 2011 May;121(5):908. PMID: 21437914
MH  - Acoustic Impedance Tests
MH  - Adult
MH  - *Catheterization
MH  - Ear Diseases/diagnostic imaging/therapy
MH  - *Eustachian Tube
MH  - Female
MH  - Humans
MH  - Male
MH  - Tomography, X-Ray Computed
EDAT- 2010/06/22 06:00
MHDA- 2010/08/07 06:00
CRDT- 2010/06/22 06:00
PHST- 2010/06/22 06:00 [entrez]
PHST- 2010/06/22 06:00 [pubmed]
PHST- 2010/08/07 06:00 [medline]
AID - 10.1002/lary.20950 [doi]
PST - ppublish
SO  - Laryngoscope. 2010 Jul;120(7):1411-6. doi: 10.1002/lary.20950.


PMID- 20564120
OWN - NLM
STAT- MEDLINE
DCOM- 20100907
LR  - 20211020
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 116
IP  - 15
DP  - 2010 Aug 1
TI  - The culture of faith and hope: patients' justifications for their high
      estimations of expected therapeutic benefit when enrolling in early phase
      oncology trials.
PG  - 3702-11
LID - 10.1002/cncr.25201 [doi]
AB  - BACKGROUND: Patients' estimates of their chances of therapeutic benefit from
      participation in early phase trials greatly exceed historical data. Ethicists
      worry that this therapeutic misestimation undermines the validity of informed
      consent. METHODS: The authors interviewed 45 patients enrolled in phase 1 or 2
      oncology trials about their expectations of therapeutic benefit and their reasons
      for those expectations. They used a phenomenological, qualitative approach with 1
      primary coder to identify emergent themes, verified by 2 independent coders.
      RESULTS: Median expectations of therapeutic benefit varied from 50% to 80%,
      depending on how the question was asked. Justifications universally invoked hope 
      and optimism, and 27 of 45 participants used 1 of these words. Three major themes
      emerged: 1) optimism as performative, that is, the notion that positive thoughts 
      and expressions improve chances of benefit; 2) fighting cancer as a battle; and
      3) faith in God, science, or both. Many participants described a culture in which
      optimism was encouraged and expected, such that trial enrollment became a way of 
      reflecting this expectation. Many reported they had been told few patients would 
      benefit and appeared to understand the uncertainties of clinical research, yet
      expressed high expected personal therapeutic benefit. More distressed
      participants were less likely to invoke performative justifications for their
      expectations (50% vs 84%; P=.04). CONCLUSIONS: Expressions of high expected
      therapeutic benefit had little to do with reporting knowledge and more to do with
      expressing optimism. These results have implications for understanding how to
      obtain valid consent from participants in early phase clinical trials.
CI  - Copyright (c) 2010 American Cancer Society.
FAU - Sulmasy, Daniel P
AU  - Sulmasy DP
AD  - Department of Medicine, MacLean Center for Clinical Medical Ethics, Divinity
      School, University of Chicago, Chicago, Illinois 60637, USA.
      dsulmasy@uchicago.edu
FAU - Astrow, Alan B
AU  - Astrow AB
FAU - He, M Kai
AU  - He MK
FAU - Seils, Damon M
AU  - Seils DM
FAU - Meropol, Neal J
AU  - Meropol NJ
FAU - Micco, Ellyn
AU  - Micco E
FAU - Weinfurt, Kevin P
AU  - Weinfurt KP
LA  - eng
GR  - R01 CA100771/CA/NCI NIH HHS/United States
GR  - R01CA100771/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
SB  - IM
MH  - *Attitude to Health
MH  - *Clinical Trials as Topic
MH  - Comprehension
MH  - Female
MH  - Humans
MH  - Informed Consent/ethics
MH  - Interviews as Topic
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/*psychology/*therapy
MH  - Patient Selection
MH  - Religion and Medicine
MH  - Therapeutic Misconception/*ethics
PMC - PMC3644988
MID - NIHMS453127
EDAT- 2010/06/22 06:00
MHDA- 2010/09/08 06:00
CRDT- 2010/06/22 06:00
PHST- 2010/06/22 06:00 [entrez]
PHST- 2010/06/22 06:00 [pubmed]
PHST- 2010/09/08 06:00 [medline]
AID - 10.1002/cncr.25201 [doi]
PST - ppublish
SO  - Cancer. 2010 Aug 1;116(15):3702-11. doi: 10.1002/cncr.25201.


PMID- 20563938
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20100621
IS  - 1532-8015 (Electronic)
IS  - 1040-1334 (Linking)
VI  - 22
IP  - 3
DP  - 2010 Jul
TI  - Community service and the pediatric exam: an introduction to clinical medicine
      via a partnership between first year medical students and a community elementary 
      school.
PG  - 187-90
LID - 10.1080/10401334.2010.488201 [doi]
AB  - BACKGROUND: Introduction to clinical medicine courses traditionally focus on
      inpatient wards or ignore the well-child exam. PURPOSE: This program uses an
      elementary school setting to give 1st-year medical students experience in the
      well pediatric exam while emphasizing service learning. The program has both
      learning and service objectives. Medical students learn the art of the pediatric 
      exam while providing a service for an underserved population. Medical students
      visit a community school and receive lectures about the roles of different
      providers and the well being of school children. Under faculty guidance they
      conduct physical exams on kindergartners. METHODS: For 2005-2007, 301 medical
      students participated. RESULTS: Medical student evaluations of the experience,
      measured on a 5-point Likert scale, are overwhelmingly favorable. CONCLUSIONS:
      The program provides a model for early clinical experience that embraces service 
      learning. It instills an ethic of service and illustrates how the community can
      be a valuable teaching resource.
FAU - McConnell, Erin
AU  - McConnell E
AD  - Internal Medicine and Pediatrics, Boonshoft School of Medicine, Wright State
      University, Dayton, Ohio, USA. erin.mcconnell@wright.edu
FAU - Clasen, Carla
AU  - Clasen C
FAU - Stolfi, Adrienne
AU  - Stolfi A
FAU - Anderson, Dustin
AU  - Anderson D
FAU - Markert, Ronald J
AU  - Markert RJ
FAU - Jaballas, Elvira
AU  - Jaballas E
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Teach Learn Med
JT  - Teaching and learning in medicine
JID - 8910884
SB  - IM
MH  - Child Welfare
MH  - Child, Preschool
MH  - Community Health Services/*organization & administration
MH  - Curriculum
MH  - Education, Medical/methods/organization & administration
MH  - Humans
MH  - Ohio
MH  - Pediatrics/*methods/organization & administration
MH  - Physical Examination/*methods
MH  - School Health Services/organization & administration
MH  - *Schools
MH  - *Students, Medical
EDAT- 2010/06/22 06:00
MHDA- 2011/01/07 06:00
CRDT- 2010/06/22 06:00
PHST- 2010/06/22 06:00 [entrez]
PHST- 2010/06/22 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
AID - 923148916 [pii]
AID - 10.1080/10401334.2010.488201 [doi]
PST - ppublish
SO  - Teach Learn Med. 2010 Jul;22(3):187-90. doi: 10.1080/10401334.2010.488201.


PMID- 20563877
OWN - NLM
STAT- MEDLINE
DCOM- 20111004
LR  - 20211020
IS  - 1433-7339 (Electronic)
IS  - 0941-4355 (Linking)
VI  - 19
IP  - 7
DP  - 2011 Jul
TI  - Cancer-related psychosocial research: what are the perspectives of cancer care
      centre users on participation?
PG  - 1029-35
LID - 10.1007/s00520-010-0931-9 [doi]
AB  - PURPOSE: To explore the perspectives of cancer care centre users on participation
      in psychosocial research to inform research design and ethics. METHODS: The study
      is based on a qualitative research design. Fourteen semistructured interviews
      were carried in people diagnosed with cancer and carers. The interview included
      four main questions about practical barriers to participation, types of research 
      design, motivating factors and the conduct of research in a cancer care support
      setting. The data were analysed using qualitative content analysis. RESULTS:
      Interviewees demonstrated a willingness to participate in psychosocial research
      within certain circumstances. There were no practical barriers identified,
      although they considered payment for research-related travel important. The most 
      acceptable research design was the face-to-face interview and the least preferred
      was the randomised control trial. The factors that motivated participation were
      altruism, valuing research, and making a contribution to the centre. Interviewees
      supported the conduct of research in cancer care support centres conditional upon
      delaying recruitment during the initial months of users' visits and its need to
      be discreet to avoid deterring visitors from accessing the centre. CONCLUSIONS:
      The study concludes that the personal interaction between participants and
      researchers is the most important feature of decision-making by patients/carers
      to join studies. Taking into account the perspectives of people affected by
      cancer during the early stages of research design may enhance recruitment and
      retention and can contribute to the development of research protocols and ethics.
FAU - Hepworth, Julie
AU  - Hepworth J
AD  - School of Nursing and Midwifery, The University of Queensland, Brisbane,
      Australia. j.hepworth@uq.edu.au
FAU - Robertson, Ann R R
AU  - Robertson AR
FAU - Jhunjhunwala, Anita
AU  - Jhunjhunwala A
FAU - Jarvis, Glyn C
AU  - Jarvis GC
FAU - McVittie, Chris
AU  - McVittie C
LA  - eng
PT  - Journal Article
DEP - 20100620
PL  - Germany
TA  - Support Care Cancer
JT  - Supportive care in cancer : official journal of the Multinational Association of 
      Supportive Care in Cancer
JID - 9302957
SB  - IM
MH  - Altruism
MH  - Decision Making
MH  - *Ethics, Research
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Interview, Psychological
MH  - Motivation
MH  - Neoplasms/*psychology
MH  - *Oncology Service, Hospital
MH  - Patient Participation/*psychology
MH  - Patient Selection/*ethics
MH  - Qualitative Research
MH  - Surveys and Questionnaires
MH  - Tape Recording
EDAT- 2010/06/22 06:00
MHDA- 2011/10/05 06:00
CRDT- 2010/06/22 06:00
PHST- 2010/03/18 00:00 [received]
PHST- 2010/05/31 00:00 [accepted]
PHST- 2010/06/22 06:00 [entrez]
PHST- 2010/06/22 06:00 [pubmed]
PHST- 2011/10/05 06:00 [medline]
AID - 10.1007/s00520-010-0931-9 [doi]
PST - ppublish
SO  - Support Care Cancer. 2011 Jul;19(7):1029-35. doi: 10.1007/s00520-010-0931-9. Epub
      2010 Jun 20.


PMID- 20563679
OWN - NLM
STAT- MEDLINE
DCOM- 20101123
LR  - 20160707
IS  - 1437-1588 (Electronic)
IS  - 1436-9990 (Linking)
VI  - 53
IP  - 6
DP  - 2010 Jun
TI  - [Annual report of the German Central Ethics Committee for Stem Cell Research :
      Seventh report after enactment of the Stem Cell Act for the reporting period 1
      December 2008 to 30 November 2009].
PG  - 623-8
LID - 10.1007/s00103-010-1071-6 [doi]
LA  - ger
PT  - Journal Article
TT  - Tatigkeitsbericht der Zentralen Ethik-Kommission fur Stammzellenforschung (ZES) :
      Siebenter Bericht nach Inkrafttreten des Stammzellgesetzes (StZG) fur den
      Zeitraum vom 01.12.2008 bis 30.11.2009.
PL  - Germany
TA  - Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
JT  - Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
JID - 101181368
SB  - IM
MH  - Embryo Research/*ethics/*legislation & jurisprudence
MH  - *Ethics Committees
MH  - Germany
MH  - Humans
MH  - *Stem Cells
EDAT- 2010/06/22 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/06/22 06:00
PHST- 2010/06/22 06:00 [entrez]
PHST- 2010/06/22 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1007/s00103-010-1071-6 [doi]
PST - ppublish
SO  - Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2010
      Jun;53(6):623-8. doi: 10.1007/s00103-010-1071-6.


PMID- 20563381
OWN - NLM
STAT- MEDLINE
DCOM- 20101214
LR  - 20190823
IS  - 1678-4464 (Electronic)
IS  - 0102-311X (Linking)
VI  - 26
IP  - 5
DP  - 2010 May
TI  - Debate on the paper by Feitosa et al. Is an interethnic ethic possible?
      Reflections on indigenous infanticide.
PG  - 866-7
LID - S0102-311X2010000500003 [pii]
FAU - Lorenzo, Claudio
AU  - Lorenzo C
AD  - Faculdade de Ciencias da Saude, Universidade de Brasilia, Brasilia, Brazil.
      claudiolorenzo@unb.br
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - Brazil
TA  - Cad Saude Publica
JT  - Cadernos de saude publica
JID - 8901573
SB  - IM
CON - Cad Saude Publica. 2010 May;26(5):853-65. PMID: 20563380
CIN - Cad Saude Publica. 2010 May;26(5):876-8. PMID: 20563387
MH  - *Bioethical Issues
MH  - Brazil/ethnology
MH  - *Cultural Diversity
MH  - Female
MH  - Humans
MH  - Indians, South American/*ethnology
MH  - Infant
MH  - Infant, Newborn
MH  - Infanticide/*ethics/*ethnology
EDAT- 2010/06/22 06:00
MHDA- 2010/12/16 06:00
CRDT- 2010/06/22 06:00
PHST- 2010/06/22 06:00 [entrez]
PHST- 2010/06/22 06:00 [pubmed]
PHST- 2010/12/16 06:00 [medline]
AID - S0102-311X2010000500003 [pii]
AID - 10.1590/s0102-311x2010000500003 [doi]
PST - ppublish
SO  - Cad Saude Publica. 2010 May;26(5):866-7. doi: 10.1590/s0102-311x2010000500003.


PMID- 20563380
OWN - NLM
STAT- MEDLINE
DCOM- 20101214
LR  - 20190823
IS  - 1678-4464 (Electronic)
IS  - 0102-311X (Linking)
VI  - 26
IP  - 5
DP  - 2010 May
TI  - Bioethics, culture and infanticide in Brazilian indigenous communities: the
      Zuruaha case.
PG  - 853-65
LID - S0102-311X2010000500002 [pii]
AB  - This article analyzes the practice of infanticide in indigenous communities in
      Brazil. Taking as a reference point a specific case involving two children of the
      Zuruaha people, it takes a broader look at the issue and discusses how
      infanticide is understood among other indigenous peoples. A debate focusing
      specifically on this topic that took place during a public hearing held in the
      Brazilian National Congress in December 2005 has also been taken into
      consideration in this discussion. In view of the positions adopted as a result of
      the hearing, this paper seeks to identify the ethical problems and moral dilemmas
      relating to the subject, by putting them into context and analyzing them in the
      light of respect for cultural pluralism. Seeking to contribute to the debate, the
      authors analyze the possibilities for intervention in the traditional practices
      of infanticide, while rejecting those positions that are not anchored in an
      attitude of profound respect for other people's cultures or that do not create
      conditions for dialogue between individuals or groups with different moralities.
FAU - Feitosa, Saulo Ferreira
AU  - Feitosa SF
AD  - Catedra UNESCO de Bioetica, Universidade de Brasilia, Brasilia, Brazil.
FAU - Garrafa, Volnei
AU  - Garrafa V
FAU - Cornelli, Gabriele
AU  - Cornelli G
FAU - Tardivo, Carla
AU  - Tardivo C
FAU - Carvalho, Samuel Jose de
AU  - Carvalho SJ
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - Cad Saude Publica
JT  - Cadernos de saude publica
JID - 8901573
SB  - IM
CIN - Cad Saude Publica. 2010 May;26(5):866-7. PMID: 20563381
CIN - Cad Saude Publica. 2010 May;26(5):867-9. PMID: 20563382
CIN - Cad Saude Publica. 2010 May;26(5):869-71. PMID: 20563383
CIN - Cad Saude Publica. 2010 May;26(5):871-3. PMID: 20563384
CIN - Cad Saude Publica. 2010 May;26(5):873-4. PMID: 20563385
CIN - Cad Saude Publica. 2010 May;26(5):875-6. PMID: 20563386
MH  - Attitude
MH  - *Bioethical Issues
MH  - Brazil/ethnology
MH  - *Cultural Diversity
MH  - Female
MH  - Humans
MH  - Indians, South American/*ethnology
MH  - Infant
MH  - Infant, Newborn
MH  - Infanticide/*ethics/*ethnology
MH  - Morals
MH  - Suicide/ethics/ethnology
EDAT- 2010/06/22 06:00
MHDA- 2010/12/16 06:00
CRDT- 2010/06/22 06:00
PHST- 2009/05/04 00:00 [received]
PHST- 2009/05/11 00:00 [accepted]
PHST- 2010/06/22 06:00 [entrez]
PHST- 2010/06/22 06:00 [pubmed]
PHST- 2010/12/16 06:00 [medline]
AID - S0102-311X2010000500002 [pii]
AID - 10.1590/s0102-311x2010000500002 [doi]
PST - ppublish
SO  - Cad Saude Publica. 2010 May;26(5):853-65. doi: 10.1590/s0102-311x2010000500002.


PMID- 20562748
OWN - NLM
STAT- MEDLINE
DCOM- 20100827
LR  - 20151119
IS  - 0353-5053 (Print)
IS  - 0353-5053 (Linking)
VI  - 22
IP  - 2
DP  - 2010 Jun
TI  - Religious moral beliefs as mental health protective factor of war veterans
      suffering from PTSD, depressiveness, anxiety, tobacco and alcohol abuse in
      comorbidity.
PG  - 203-10
AB  - INTRODUCTION: Our aim was to investigate is there association between level of
      religious moral beliefs and severity of PTSD symptoms, depressiion symptoms,
      anxiety and severity of alcohol abuse we tested 152 war veterans on presence of
      PTSD, depression symptoms, anxiety, alcohol misuse and level of religious moral
      beliefs. SUBJECTS AND METHODS: We used Harvard trauma questionnaire (HTQ),
      Hopkins Check Scale SBCL 25, check list for alcohol misuse MAST. Subjects were
      assessed with regard to the level of belief in some basic ethical principles that
      arise from religious moral values. The score of religious moral belief index was 
      used to correlate with severity of PTSD symptoms, depression symptoms, anxiety
      and severity of alcohol misuse. RESULTS: Mean age of tested subjects was 40.8
      (SD=6.6) years. The score of the moral belief index was negatively correlated to 
      PTSD symptom severity and depressiveness (Pearson's r=-0.325, p<0.001; r=-0.247, 
      p=0.005, respectively). Besides that the score of moral belief index negatively
      correlated with presented anxiety (Pearson's r=-0.199,p=0.026). Related to
      severity of tobacco and alcohol misuse we found negative association of these
      with the moral belief index (Pearson's r=-0.227, p=0.011; r=-0.371, p<0.001,
      respectively). CONCLUSION: A higher index of religious moral beliefs in war
      veterans enables better control distress, providing better mental health
      stability. It enables post traumatic conflicts typical for combatants' survivors 
      to be more easily overcome. It also causes healthier reactions to external
      stimuli. A higher index of religious moral beliefs of war veterans provides a
      healthier and more efficient mechanism of tobacco and alcohol misuse control. In 
      this way, it helps overcoming postwar psychosocial problems and socialization of 
      the personality, leading to the improvement in mental health.
FAU - Hasanovic, Mevludin
AU  - Hasanovic M
AD  - University Clinical Centre Tuzla, School of Medicine University of Tuzla, Bosna
      and Herzegovina. hameaz@bih.net.ba
FAU - Pajevic, Izet
AU  - Pajevic I
LA  - eng
PT  - Journal Article
PL  - Croatia
TA  - Psychiatr Danub
JT  - Psychiatria Danubina
JID - 9424753
SB  - IM
MH  - Adaptation, Psychological
MH  - Adult
MH  - Alcoholism/epidemiology/*psychology
MH  - Anxiety Disorders/diagnosis/epidemiology/*psychology
MH  - Bosnia and Herzegovina
MH  - Combat Disorders/diagnosis/epidemiology/*psychology
MH  - Comorbidity
MH  - *Culture
MH  - Depressive Disorder/diagnosis/epidemiology/*psychology
MH  - Humans
MH  - Internal-External Control
MH  - Male
MH  - Middle Aged
MH  - *Morals
MH  - Personality Inventory/statistics & numerical data
MH  - Psychometrics
MH  - *Religion and Psychology
MH  - Smoking/epidemiology/*psychology
MH  - Social Values
MH  - Socialization
MH  - Stress Disorders, Post-Traumatic/diagnosis/epidemiology/*psychology
MH  - Veterans/*psychology/statistics & numerical data
MH  - *Warfare
EDAT- 2010/06/22 06:00
MHDA- 2010/08/28 06:00
CRDT- 2010/06/22 06:00
PHST- 2010/06/22 06:00 [entrez]
PHST- 2010/06/22 06:00 [pubmed]
PHST- 2010/08/28 06:00 [medline]
PST - ppublish
SO  - Psychiatr Danub. 2010 Jun;22(2):203-10.


PMID- 20562251
OWN - NLM
STAT- MEDLINE
DCOM- 20110524
LR  - 20101223
IS  - 1049-7323 (Print)
IS  - 1049-7323 (Linking)
VI  - 21
IP  - 1
DP  - 2011 Jan
TI  - Cancer as rubbish: donation of tumor tissue for research.
PG  - 75-84
LID - 10.1177/1049732310373753 [doi]
AB  - Tissue banking (or biobanking), thought by many to be an essential form of
      medical research, has raised a number of ethical issues that highlight a need to 
      understand the beliefs and values of tissue donors, including the motivations
      underlying consent or refusal to donate. Data from our qualitative study of the
      legal, social, and ethical issues surrounding tumor banking in New South Wales,
      Australia, show that participants' attitudes to donation of tumor tissue for
      research are partially captured by theories of weak altruism and social exchange.
      However, we argue that the psychological rewards of value transformation
      described by Thompson's rubbish theory provide additional insights into
      participants' attitudes to tumor donation. We believe our data provides
      sufficient justification for an approach to regulation of tumor banking that is
      aimed at fostering a relationship based on the notions of virtuous reassignment
      and social exchange.
FAU - Morrell, Bronwen
AU  - Morrell B
AD  - Centre for Values, Ethics and the Law in Medicine, University of Sydney, Sydney, 
      New South Wales, Australia. bronwenmorrell@gmail.com
FAU - Lipworth, Wendy
AU  - Lipworth W
FAU - Axler, Renata
AU  - Axler R
FAU - Kerridge, Ian
AU  - Kerridge I
FAU - Little, Miles
AU  - Little M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100618
PL  - United States
TA  - Qual Health Res
JT  - Qualitative health research
JID - 9202144
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Altruism
MH  - Biomedical Research/*ethics/standards
MH  - Female
MH  - Humans
MH  - Informed Consent
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/genetics/*pathology/*psychology
MH  - New South Wales
MH  - Tissue Banks/*ethics
MH  - Tissue Donors/ethics/*psychology
EDAT- 2010/06/22 06:00
MHDA- 2011/05/25 06:00
CRDT- 2010/06/22 06:00
PHST- 2010/06/22 06:00 [entrez]
PHST- 2010/06/22 06:00 [pubmed]
PHST- 2011/05/25 06:00 [medline]
AID - 1049732310373753 [pii]
AID - 10.1177/1049732310373753 [doi]
PST - ppublish
SO  - Qual Health Res. 2011 Jan;21(1):75-84. doi: 10.1177/1049732310373753. Epub 2010
      Jun 18.


PMID- 20561739
OWN - NLM
STAT- MEDLINE
DCOM- 20110211
LR  - 20101011
IS  - 1872-7654 (Electronic)
IS  - 0301-2115 (Linking)
VI  - 152
IP  - 2
DP  - 2010 Oct
TI  - The ethics of abortions for fetuses with congenital abnormalities.
PG  - 148-51
LID - 10.1016/j.ejogrb.2010.05.030 [doi]
AB  - Abortion remains a highly contentious moral issue, with the debate usually framed
      as a battle between the fetus's right to life and the woman's right to choose.
      Often overlooked in this debate is the impact of the concurrent legalization of
      abortion and the development of new prenatal screening tests on the birth
      prevalence of many inherited diseases. Most proponents of abortion support
      abortion for fetuses with severe congenital diseases, but there has unfortunately
      been, in our opinion, too little debate over the moral appropriateness of
      abortion for much less severe congenital conditions such as Down's syndrome,
      deafness, and dwarfism. Due to scientific advances, we are looking at a future in
      which prenatal diagnosis will be safer and more accurate, raising the specter,
      and the concomitant ethical concerns, of wholesale abortions. Herein, we present 
      a reframing of the abortion debate that better encompasses these conditions and
      offers a more nuanced position.
CI  - Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Jotkowitz, Alan
AU  - Jotkowitz A
AD  - The Jakobovits Center for Jewish Medical Ethics and the Department of Medicine,
      Faculty of Medicine, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
FAU - Zivotofsky, Ari Z
AU  - Zivotofsky AZ
LA  - eng
PT  - Journal Article
DEP - 20100618
PL  - Ireland
TA  - Eur J Obstet Gynecol Reprod Biol
JT  - European journal of obstetrics, gynecology, and reproductive biology
JID - 0375672
SB  - IM
MH  - Abortion, Induced/*ethics
MH  - Congenital Abnormalities/*diagnosis
MH  - Down Syndrome/diagnosis
MH  - Female
MH  - Genetic Diseases, Inborn
MH  - Humans
MH  - Pregnancy
MH  - Prenatal Diagnosis/*ethics
MH  - Value of Life
EDAT- 2010/06/22 06:00
MHDA- 2011/02/12 06:00
CRDT- 2010/06/22 06:00
PHST- 2010/02/21 00:00 [received]
PHST- 2010/05/04 00:00 [revised]
PHST- 2010/05/25 00:00 [accepted]
PHST- 2010/06/22 06:00 [entrez]
PHST- 2010/06/22 06:00 [pubmed]
PHST- 2011/02/12 06:00 [medline]
AID - S0301-2115(10)00275-7 [pii]
AID - 10.1016/j.ejogrb.2010.05.030 [doi]
PST - ppublish
SO  - Eur J Obstet Gynecol Reprod Biol. 2010 Oct;152(2):148-51. doi:
      10.1016/j.ejogrb.2010.05.030. Epub 2010 Jun 18.


PMID- 20561091
OWN - NLM
STAT- MEDLINE
DCOM- 20110801
LR  - 20211020
IS  - 1742-1241 (Electronic)
IS  - 1368-5031 (Linking)
VI  - 64
IP  - 9
DP  - 2010 Aug
TI  - How ethical is your clinical trial?
PG  - 1179-82
LID - 10.1111/j.1742-1241.2010.02421.x [doi]
FAU - Miller, L
AU  - Miller L
AD  - AVAC, Global Advocacy for HIV Prevention, New York, NY 10011, USA. lori@avac.org
FAU - Folayan, M
AU  - Folayan M
FAU - Allman, D
AU  - Allman D
FAU - Nkala, B
AU  - Nkala B
FAU - Kasirye, L M
AU  - Kasirye LM
FAU - Mingote, L R
AU  - Mingote LR
FAU - Calazans, G
AU  - Calazans G
FAU - Mburu, R
AU  - Mburu R
FAU - Ntombela, F
AU  - Ntombela F
FAU - Ditmore, M
AU  - Ditmore M
LA  - eng
GR  - T32 DA007233/DA/NIDA NIH HHS/United States
GR  - 5T32DA07233/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100616
PL  - India
TA  - Int J Clin Pract
JT  - International journal of clinical practice
JID - 9712381
SB  - IM
MH  - Clinical Trials as Topic/*ethics
MH  - Ethics, Research
MH  - Informed Consent/ethics
PMC - PMC2916216
EDAT- 2010/06/22 06:00
MHDA- 2011/08/02 06:00
CRDT- 2010/06/22 06:00
PHST- 2010/06/22 06:00 [entrez]
PHST- 2010/06/22 06:00 [pubmed]
PHST- 2011/08/02 06:00 [medline]
AID - IJCP2421 [pii]
AID - 10.1111/j.1742-1241.2010.02421.x [doi]
PST - ppublish
SO  - Int J Clin Pract. 2010 Aug;64(9):1179-82. doi: 10.1111/j.1742-1241.2010.02421.x. 
      Epub 2010 Jun 16.


PMID- 20560990
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20151119
IS  - 1399-0012 (Electronic)
IS  - 0902-0063 (Linking)
VI  - 25
IP  - 3
DP  - 2011 May-Jun
TI  - Attitude toward xenotransplantation of patients prior and after human organ
      transplantation.
PG  - 495-503
LID - 10.1111/j.1399-0012.2010.01296.x [doi]
AB  - Xenotransplantation is a potential strategy to overcome the shortage of human
      donor organs. As this technique has a major medical and psychological impact on
      patients and their family and friends, the attitude of patients currently waiting
      for organ transplantation is important. Therefore, we conducted a survey on the
      attitude toward xenotransplantation of patients on the waiting list and already
      transplanted patients. Patients received detailed information before being asked 
      to fill in the questionnaire. We found that 65% would accept xenotransplantation,
      irrespective of gender, education level or if the patients were on the waiting
      list or already transplanted. The most common concern was transmission of
      diseases or genetic material, followed by psychological concerns and ethical
      issues. More patients had a positive attitude toward accepting cell or tissue
      transplantation when compared to whole organs. Pig pancreas islet cell
      transplantation is generally well accepted, patients with diabetes mellitus show 
      even higher acceptance rates than patients without diabetes. In conclusion,
      xenotransplantation seems to be well accepted in patients who are potential
      future candidates for organ transplantation. Informing patients about the current
      status of research tended to decrease acceptance rates slightly.
CI  - (c) 2010 John Wiley & Sons A/S.
FAU - Stadlbauer, V
AU  - Stadlbauer V
AD  - Department of Internal Medicine, University Hospital Graz, Graz, Austria.
      vanessa.stadlbauer@meduni-graz.at
FAU - Stiegler, P
AU  - Stiegler P
FAU - Muller, S
AU  - Muller S
FAU - Schweiger, M
AU  - Schweiger M
FAU - Sereingg, M
AU  - Sereingg M
FAU - Tscheliessnigg, K H
AU  - Tscheliessnigg KH
FAU - Freidl, W
AU  - Freidl W
LA  - eng
PT  - Journal Article
DEP - 20100706
PL  - Denmark
TA  - Clin Transplant
JT  - Clinical transplantation
JID - 8710240
SB  - IM
MH  - Animals
MH  - *Attitude to Health
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Organ Transplantation/*psychology
MH  - Patient Acceptance of Health Care/*psychology
MH  - Patients/*psychology
MH  - Prognosis
MH  - Surveys and Questionnaires
MH  - Swine
MH  - Tissue Donors
MH  - Tissue and Organ Procurement
MH  - Transplantation, Heterologous/*psychology
MH  - *Waiting Lists
EDAT- 2010/06/22 06:00
MHDA- 2011/10/01 06:00
CRDT- 2010/06/22 06:00
PHST- 2010/06/22 06:00 [entrez]
PHST- 2010/06/22 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - CTR1296 [pii]
AID - 10.1111/j.1399-0012.2010.01296.x [doi]
PST - ppublish
SO  - Clin Transplant. 2011 May-Jun;25(3):495-503. doi:
      10.1111/j.1399-0012.2010.01296.x. Epub 2010 Jul 6.


PMID- 20560970
OWN - NLM
STAT- MEDLINE
DCOM- 20100916
LR  - 20130603
IS  - 1365-2141 (Electronic)
IS  - 0007-1048 (Linking)
VI  - 150
IP  - 4
DP  - 2010 Aug
TI  - A pilot study of the Histone-Deacetylase inhibitor Givinostat in patients with
      JAK2V617F positive chronic myeloproliferative neoplasms.
PG  - 446-55
LID - 10.1111/j.1365-2141.2010.08266.x [doi]
AB  - A phase II A study was conducted to evaluate the safety and efficacy of
      Givinostat, a novel Histone-Deacetylases inhibitor, in patients with
      Polycythaemia Vera (PV, n = 12), Essential Thrombocythaemia (ET, n = 1) and
      Myelofibrosis (n = 16), bearing the JAK2V617F mutation. The study was approved by
      the local ethics committees and all human participants gave written informed
      consent. Givinostat was given orally for 24 weeks at a starting dose of 50 mg
      twice daily. The median treatment duration was 20 weeks. Reasons for treatment
      discontinuation were disease progression (n = 6), grade 2 thrombocytopenia (n =
      1), psychiatric symptoms (n = 1) and withdrawn consent (n = 2). A dose reduction 
      was applied in 10 patients while a temporary interruption occurred in 15. Among
      13 PV/ET patients, 1 complete, 6 partial and 4 no responses were documented at
      study end while 2 patients went off-study, prematurely. Three major responses
      were registered among 16 MF patients. Pruritus disappeared in most patients and
      reduction of splenomegaly was observed in 75% of PV/ET and 38% of MF patients.
      Reverse transcription polymerase chain reaction identified a trend to reduction
      of the JAK2V617F allele burden. Givinostat was well tolerated and could induce
      haematological response in most PV and some MF patients.
FAU - Rambaldi, Alessandro
AU  - Rambaldi A
AD  - Haematology, Ospedali Riuniti Di Bergamo, Largo Barozzi, Bergamo, Italy.
      arambaldi@ospedaliriuniti.bergamo.it
FAU - Dellacasa, Chiara Maria
AU  - Dellacasa CM
FAU - Finazzi, Guido
AU  - Finazzi G
FAU - Carobbio, Alessandra
AU  - Carobbio A
FAU - Ferrari, Maria Luisa
AU  - Ferrari ML
FAU - Guglielmelli, Paola
AU  - Guglielmelli P
FAU - Gattoni, Elisabetta
AU  - Gattoni E
FAU - Salmoiraghi, Silvia
AU  - Salmoiraghi S
FAU - Finazzi, Maria Chiara
AU  - Finazzi MC
FAU - Di Tollo, Silvia
AU  - Di Tollo S
FAU - D'Urzo, Carmine
AU  - D'Urzo C
FAU - Vannucchi, Alessandro M
AU  - Vannucchi AM
FAU - Barosi, Giovanni
AU  - Barosi G
FAU - Barbui, Tiziano
AU  - Barbui T
LA  - eng
PT  - Clinical Trial, Phase II
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20100615
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
RN  - 0 (Histone Deacetylase Inhibitors)
RN  - 0 (Hydroxamic Acids)
RN  - EC 2.7.10.2 (JAK2 protein, human)
RN  - EC 2.7.10.2 (Janus Kinase 2)
RN  - Z02132R2QQ (givinostat hydrochloride)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Drug Administration Schedule
MH  - Female
MH  - Histone Deacetylase Inhibitors/administration & dosage/*adverse
      effects/therapeutic use
MH  - Humans
MH  - Hydroxamic Acids/administration & dosage/*adverse effects/therapeutic use
MH  - Janus Kinase 2/genetics
MH  - Male
MH  - Middle Aged
MH  - Myeloproliferative Disorders/*drug therapy/genetics
MH  - Pilot Projects
MH  - Polycythemia Vera/drug therapy/genetics
MH  - Primary Myelofibrosis/drug therapy/genetics
MH  - Thrombocythemia, Essential/drug therapy/genetics
MH  - Treatment Outcome
EDAT- 2010/06/22 06:00
MHDA- 2010/09/18 06:00
CRDT- 2010/06/22 06:00
PHST- 2010/06/22 06:00 [entrez]
PHST- 2010/06/22 06:00 [pubmed]
PHST- 2010/09/18 06:00 [medline]
AID - BJH8266 [pii]
AID - 10.1111/j.1365-2141.2010.08266.x [doi]
PST - ppublish
SO  - Br J Haematol. 2010 Aug;150(4):446-55. doi: 10.1111/j.1365-2141.2010.08266.x.
      Epub 2010 Jun 15.


PMID- 20560025
OWN - NLM
STAT- MEDLINE
DCOM- 20101004
LR  - 20211203
IS  - 1937-5395 (Electronic)
IS  - 1937-5387 (Linking)
VI  - 3
IP  - 2
DP  - 2010 Apr
TI  - Stem cells and ethics: current issues.
PG  - 122-7
LID - 10.1007/s12265-009-9155-0 [doi]
AB  - Much attention has recently turned to the promise and potential of human stem
      cells in therapeutic applications for the repair of cardiac tissue. The advances 
      being made in the laboratory are exciting, and the pace at which research using
      human stem cells is moving from bench to bedside is extraordinary. The social,
      ethical, and policy considerations embedded within this area of research also
      require a large amount of attention and deliberation so that the scientific
      progress is able to successfully continue without social backlash.
FAU - McCormick, Jennifer Blair
AU  - McCormick JB
AD  - Departments of Medicine and Health Sciences Research, Bioethics Research Group,
      Mayo Clinic and College of Medicine, Rochester, MN, 55905, USA.
      mccormick.jb@mayo.edu
FAU - Huso, Holly A
AU  - Huso HA
LA  - eng
GR  - UL1 RR024150/RR/NCRR NIH HHS/United States
GR  - UL1 RR024150-01/RR/NCRR NIH HHS/United States
GR  - 1 UL1 RR024150-01/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20091201
PL  - United States
TA  - J Cardiovasc Transl Res
JT  - Journal of cardiovascular translational research
JID - 101468585
SB  - IM
MH  - Embryo Research/*ethics/legislation & jurisprudence
MH  - Health Policy
MH  - Humans
MH  - Informed Consent/ethics
MH  - Intellectual Property
MH  - Public Opinion
MH  - Public Policy
MH  - Risk Assessment
MH  - Stem Cell Transplantation/adverse effects/*ethics/legislation & jurisprudence
MH  - Tissue Donors/ethics
MH  - Translational Research, Biomedical/*ethics/legislation & jurisprudence
PMC - PMC3933367
MID - NIHMS171472
EDAT- 2010/06/19 06:00
MHDA- 2010/10/05 06:00
CRDT- 2010/06/19 06:00
PHST- 2009/09/14 00:00 [received]
PHST- 2009/11/06 00:00 [accepted]
PHST- 2010/06/19 06:00 [entrez]
PHST- 2010/06/19 06:00 [pubmed]
PHST- 2010/10/05 06:00 [medline]
AID - 10.1007/s12265-009-9155-0 [doi]
PST - ppublish
SO  - J Cardiovasc Transl Res. 2010 Apr;3(2):122-7. doi: 10.1007/s12265-009-9155-0.
      Epub 2009 Dec 1.


PMID- 20559755
OWN - NLM
STAT- MEDLINE
DCOM- 20110202
LR  - 20220331
IS  - 1556-0961 (Electronic)
IS  - 1541-6933 (Linking)
VI  - 13
IP  - 2
DP  - 2010 Oct
TI  - A report of fetal demise during therapeutic hypothermia after cardiac arrest.
PG  - 239-42
LID - 10.1007/s12028-010-9395-5 [doi]
AB  - BACKGROUND: Therapeutic hypothermia is becoming the standard-of-care for coma
      following out-of-hospital cardiac arrest. Pregnancy has been considered a
      contraindication for therapeutic hypothermia. METHODS: Case report. RESULTS: A
      44-year-old woman presented after a witnessed out-of-hospital ventricular
      fibrillation cardiac arrest. She remained comatose upon hospital admission and
      was treated with induced hypothermia via surface cooling pads. An intrauterine
      pregnancy of 20 weeks gestation was discovered on admission. One day after
      admission, a stillborn fetus was spontaneously delivered. The patient made a good
      neurologic recovery and now lives at home with her family. CONCLUSION: During
      pregnancy, beneficence toward the pregnant woman must be the primary ethical
      guideline in emergent, life-threatening situations. Pregnancy should not be a
      contraindication to therapeutic hypothermia following cardiac arrest.
FAU - Wible, Elissa Fory
AU  - Wible EF
AD  - Department of Medicine, Duke University Medical Center, DUMC Box 2900, Durham, NC
      27710, USA. elissa.wible@gmail.com
FAU - Kass, Joseph S
AU  - Kass JS
FAU - Lopez, George A
AU  - Lopez GA
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Neurocrit Care
JT  - Neurocritical care
JID - 101156086
SB  - IM
MH  - Adult
MH  - Fatal Outcome
MH  - Female
MH  - Heart Arrest/*mortality
MH  - Humans
MH  - Hypothermia, Induced/adverse effects/*mortality
MH  - Pregnancy
MH  - Stillbirth
EDAT- 2010/06/19 06:00
MHDA- 2011/02/03 06:00
CRDT- 2010/06/19 06:00
PHST- 2010/06/19 06:00 [entrez]
PHST- 2010/06/19 06:00 [pubmed]
PHST- 2011/02/03 06:00 [medline]
AID - 10.1007/s12028-010-9395-5 [doi]
PST - ppublish
SO  - Neurocrit Care. 2010 Oct;13(2):239-42. doi: 10.1007/s12028-010-9395-5.


PMID- 20559179
OWN - NLM
STAT- MEDLINE
DCOM- 20100714
LR  - 20220317
IS  - 1357-6321 (Print)
IS  - 1357-6321 (Linking)
VI  - 16
IP  - 4
DP  - 2010 Apr
TI  - 'As long as it helps somebody': why vulnerable people participate in research.
PG  - 174-9
AB  - In the past, ethics committees and researchers have avoided research among
      vulnerable groups because of prevailing perceptions that such research is
      unethical and difficult. Taking an opposite stand, this article will argue that
      it is in fact unethical not to research vulnerable populations because, by
      excluding potential participants from research endeavours, they are being
      deprived of the benefits to be gained from research. Albeit well meaning, people 
      in vulnerable populations are also being subjected to the paternalistic attitudes
      of those who believe they know what is in the best interests of others. There is 
      ample evidence in existing literature that, not only is research among vulnerable
      populations unlikely to result in harm, but there are often benefits to be gained
      by both participants and researchers. Apart from the generic benefits of
      increased knowledge and improved health interventions, specific benefits for
      participants might be: therapeutic, cathartic, educational, empowering,
      altruistic and social. In contrast, the risks associated with researching
      vulnerable populations appear to be minimal. Yet, there is still evidence that
      health care professionals and other gatekeepers continue to hinder research
      amongst vulnerable populations through unilateral decision-making. This article
      will review existing literature on the topic of research amongst vulnerable
      populations, as well as contribute to the argument from the author's own study on
      a sensitive topic.
FAU - Alexander, Susan Jane
AU  - Alexander SJ
AD  - CQ University, Bundaberg, Queensland, Australia. s.alexander@cqu.edu.au
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Int J Palliat Nurs
JT  - International journal of palliative nursing
JID - 9506762
MH  - Beneficence
MH  - Ethics, Research
MH  - Humans
MH  - Motivation
MH  - *Palliative Care
MH  - Patient Selection/*ethics
MH  - Risk
MH  - *Vulnerable Populations
RF  - 69
EDAT- 2010/06/19 06:00
MHDA- 2010/07/16 06:00
CRDT- 2010/06/19 06:00
PHST- 2010/06/19 06:00 [entrez]
PHST- 2010/06/19 06:00 [pubmed]
PHST- 2010/07/16 06:00 [medline]
PST - ppublish
SO  - Int J Palliat Nurs. 2010 Apr;16(4):174-9.


PMID- 20558658
OWN - NLM
STAT- MEDLINE
DCOM- 20100927
LR  - 20100618
IS  - 1552-7409 (Electronic)
IS  - 0894-3184 (Linking)
VI  - 23
IP  - 3
DP  - 2010 Jul
TI  - Human dignity: a humanbecoming ethical phenomenon.
PG  - 257-62
LID - 10.1177/0894318410371841 [doi]
AB  - Human dignity is a phenomenon of interest in many disciplines, including
      health-related disciplines. The author in this article explores the ethics of
      dignity and sets forth the tenets of human dignity as a humanbecoming ethical
      phenomenon. The tenets elaborate reverence, awe, betrayal, and shame, all
      enduring truths inherently significant to human dignity.
FAU - Parse, Rosemarie Rizzo
AU  - Parse RR
AD  - Loyola University Chicago, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Nurs Sci Q
JT  - Nursing science quarterly
JID - 8805022
MH  - *Ethics
MH  - Humans
MH  - *Interpersonal Relations
MH  - Nursing
MH  - *Personhood
EDAT- 2010/06/19 06:00
MHDA- 2010/09/29 06:00
CRDT- 2010/06/19 06:00
PHST- 2010/06/19 06:00 [entrez]
PHST- 2010/06/19 06:00 [pubmed]
PHST- 2010/09/29 06:00 [medline]
AID - 23/3/257 [pii]
AID - 10.1177/0894318410371841 [doi]
PST - ppublish
SO  - Nurs Sci Q. 2010 Jul;23(3):257-62. doi: 10.1177/0894318410371841.


PMID- 20558645
OWN - NLM
STAT- MEDLINE
DCOM- 20100927
LR  - 20100618
IS  - 1552-7409 (Electronic)
IS  - 0894-3184 (Linking)
VI  - 23
IP  - 3
DP  - 2010 Jul
TI  - Failing to do the right thing: nurse practice and the family experience.
PG  - 206-8
LID - 10.1177/0894318410371851 [doi]
AB  - Ethical end of life decisions are increasingly viewed by the global healthcare
      community as complex and imbued with uncertainty in institutional healthcare
      settings. Each person experiences health decision-making and the concept of time 
      differently and uniquely. In the context of end of life situations, both the
      recipients of healthcare and their families may experience complex
      decision-making in situations where profound questioning and uncertainty surfaces
      with a struggling of desiring to do the right thing comingling with the
      possibilities of failing to do the right thing according to the expectations of
      self and others. This column begins a discussion of possible meanings found in
      ethical decision-making with families as articulated with the lens of the
      humanbecoming family model.
FAU - Milton, Constance L
AU  - Milton CL
AD  - California Baptist University, Riverside, CA 92504, USA.
      constancemilton@yahoo.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Nurs Sci Q
JT  - Nursing science quarterly
JID - 8805022
MH  - Decision Making/*ethics
MH  - Humans
MH  - Nursing Care/*ethics
MH  - *Professional-Family Relations
MH  - *Social Responsibility
MH  - Terminal Care
EDAT- 2010/06/19 06:00
MHDA- 2010/09/29 06:00
CRDT- 2010/06/19 06:00
PHST- 2010/06/19 06:00 [entrez]
PHST- 2010/06/19 06:00 [pubmed]
PHST- 2010/09/29 06:00 [medline]
AID - 23/3/206 [pii]
AID - 10.1177/0894318410371851 [doi]
PST - ppublish
SO  - Nurs Sci Q. 2010 Jul;23(3):206-8. doi: 10.1177/0894318410371851.


PMID- 20558577
OWN - NLM
STAT- MEDLINE
DCOM- 20110125
LR  - 20211020
IS  - 1525-2191 (Electronic)
IS  - 0002-9440 (Linking)
VI  - 177
IP  - 2
DP  - 2010 Aug
TI  - In vivo assessment of acute UVB responses in normal and Xeroderma Pigmentosum
      (XP-C) skin-humanized mouse models.
PG  - 865-72
LID - 10.2353/ajpath.2010.091096 [doi]
AB  - In vivo studies of UVB effects on human skin are precluded by ethical and
      technical arguments on volunteers and inconceivable in cancer-prone patients such
      as those affected with Xeroderma Pigmentosum (XP). Establishing reliable models
      to address mechanistic and therapeutic matters thus remains a challenge. Here we 
      have used the skin-humanized mouse system that circumvents most current model
      constraints. We assessed the UVB radiation effects including the sequential
      changes after acute exposure with respect to timing, dosage, and the relationship
      between dose and degree-sort of epidermal alteration. On Caucasian-derived
      regenerated skins, UVB irradiation (800 J/m(2)) induced DNA damage (cyclobutane
      pyrimidine dimers) and p53 expression in exposed keratinocytes. Epidermal
      disorganization was observed at higher doses. In contrast, in African
      descent-derived regenerated skins, physiological hyperpigmentation prevented
      tissue alterations and DNA photolesions. The acute UVB effects seen in
      Caucasian-derived engrafted skins were also blocked by a physical sunscreen,
      demonstrating the suitability of the system for photoprotection studies. We also 
      report the establishment of a photosensitive model through the transplantation of
      XP-C patient cells as part of a bioengineered skin. The inability of XP-C
      engrafted skin to remove DNA damaged cells was confirmed in vivo. Both the normal
      and XP-C versions of the skin-humanized mice proved proficient models to assess
      UVB-mediated DNA repair responses and provide a strong platform to test novel
      therapeutic strategies.
FAU - Garcia, Marta
AU  - Garcia M
AD  - Cutaneous Regenerative Medicine Unit, Epithelial Biomedicine Division, CIEMAT,
      Madrid, Spain.
FAU - Llames, Sara
AU  - Llames S
FAU - Garcia, Eva
AU  - Garcia E
FAU - Meana, Alvaro
AU  - Meana A
FAU - Cuadrado, Natividad
AU  - Cuadrado N
FAU - Recasens, Mar
AU  - Recasens M
FAU - Puig, Susana
AU  - Puig S
FAU - Nagore, Eduardo
AU  - Nagore E
FAU - Illera, Nuria
AU  - Illera N
FAU - Jorcano, Jose Luis
AU  - Jorcano JL
FAU - Del Rio, Marcela
AU  - Del Rio M
FAU - Larcher, Fernando
AU  - Larcher F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100617
PL  - United States
TA  - Am J Pathol
JT  - The American journal of pathology
JID - 0370502
RN  - 0 (Pyrimidine Dimers)
SB  - IM
MH  - Animals
MH  - Cells, Cultured
MH  - DNA Damage
MH  - DNA Repair
MH  - *Disease Models, Animal
MH  - Humans
MH  - Keratinocytes/pathology/radiation effects
MH  - Mice
MH  - Pyrimidine Dimers/genetics
MH  - Skin/cytology/pathology/*radiation effects
MH  - Skin Pigmentation
MH  - Ultraviolet Rays/*adverse effects
MH  - Xeroderma Pigmentosum/*pathology
PMC - PMC2913368
EDAT- 2010/06/19 06:00
MHDA- 2011/01/28 06:00
CRDT- 2010/06/19 06:00
PHST- 2010/06/19 06:00 [entrez]
PHST- 2010/06/19 06:00 [pubmed]
PHST- 2011/01/28 06:00 [medline]
AID - S0002-9440(10)60142-3 [pii]
AID - 10.2353/ajpath.2010.091096 [doi]
PST - ppublish
SO  - Am J Pathol. 2010 Aug;177(2):865-72. doi: 10.2353/ajpath.2010.091096. Epub 2010
      Jun 17.


PMID- 20558477
OWN - NLM
STAT- MEDLINE
DCOM- 20110204
LR  - 20101027
IS  - 1475-3901 (Electronic)
IS  - 1475-3898 (Linking)
VI  - 19
IP  - 5
DP  - 2010 Oct
TI  - Henry K Beecher: Pain, belief and truth at the bedside. The powerful placebo,
      ethical research and anaesthesia safety.
PG  - 466-8
LID - 10.1136/qshc.2010.042200 [doi]
FAU - Best, Mark
AU  - Best M
AD  - Lake Erie College of Osteopathic Medicine, 5000 Lakewood Ranch Blvd, Bradenton,
      Bradenton, FL 34211, USA. markbest20@hotmail.com
FAU - Neuhauser, Duncan
AU  - Neuhauser D
LA  - eng
PT  - Biography
PT  - Historical Article
PT  - Journal Article
DEP - 20100617
PL  - England
TA  - Qual Saf Health Care
JT  - Quality & safety in health care
JID - 101136980
MH  - *Anesthesia
MH  - Biomedical Research/*ethics/history
MH  - History, 20th Century
MH  - Humans
MH  - *Pain
MH  - *Placebo Effect
MH  - Safety Management
PS  - Beecher HK
FPS - Beecher, Henry K
EDAT- 2010/06/19 06:00
MHDA- 2011/02/05 06:00
CRDT- 2010/06/19 06:00
PHST- 2010/06/19 06:00 [entrez]
PHST- 2010/06/19 06:00 [pubmed]
PHST- 2011/02/05 06:00 [medline]
AID - qshc.2010.042200 [pii]
AID - 10.1136/qshc.2010.042200 [doi]
PST - ppublish
SO  - Qual Saf Health Care. 2010 Oct;19(5):466-8. doi: 10.1136/qshc.2010.042200. Epub
      2010 Jun 17.


PMID- 20558437
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20100707
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 7
DP  - 2010 Jul
TI  - The ethics behind medical conferences: a view from India.
PG  - 445-6
LID - 10.1136/jme.2010.035543 [doi]
AB  - Medical conferences are organised by professional bodies with a view to providing
      an opportunity of continuing medical education and improving the practices of
      medical professionals. Of late these events have degenerated into entertainment
      extravaganzas and no longer remain pure academic exercises. This article
      discusses the possible reasons behind the current state of decay and mechanisms
      to improve the state of affairs.
FAU - Sharma, Vishal
AU  - Sharma V
AD  - Department of Medicine, University College of Medical Sciences, Delhi, India.
      docvishalsharma@gmail.com
FAU - Sharma, Alka
AU  - Sharma A
LA  - eng
PT  - Journal Article
DEP - 20100616
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Conflict of Interest
MH  - Congresses as Topic/*ethics/organization & administration
MH  - Drug Industry/*ethics
MH  - Humans
MH  - India
EDAT- 2010/06/19 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/06/19 06:00
PHST- 2010/06/19 06:00 [entrez]
PHST- 2010/06/19 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - jme.2010.035543 [pii]
AID - 10.1136/jme.2010.035543 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Jul;36(7):445-6. doi: 10.1136/jme.2010.035543. Epub 2010 Jun
      16.


PMID- 20558436
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20220309
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 7
DP  - 2010 Jul
TI  - Life-prolonging treatment in nursing homes: how do physicians and nurses describe
      and justify their own practice?
PG  - 396-400
LID - 10.1136/jme.2010.036244 [doi]
AB  - BACKGROUND: Making the right decisions, while simultaneously showing respect for 
      patient autonomy, represents a great challenge to nursing home staff in the
      issues of life-prolonging treatment, hydration, nutrition and hospitalisation to 
      dying patents in end-of-life. OBJECTIVES: To study how physicians and nurses
      protect nursing home patients' autonomy in end-of-life decisions, and how they
      justify their practice. DESIGN: A qualitative descriptive design with analysis of
      the content of transcribed in-depth interviews with physicians and nurses.
      PARTICIPANTS: Nine physicians and ten nurses in 10 nursing homes in Norway.
      RESULTS AND INTERPRETATIONS: Assessment of the patient's competence to consent to
      treatment is almost absent. The physicians build their practice on the principles
      of beneficence and nonmaleficence. Nurses tend to trust the patients' rejection
      of life support, even when the patients have difficulty speaking or suffer from
      dementia. Relatives were, according to the health personnel, included in
      decision-making processes to a very limited extent. However, futile life support 
      is sometimes provided contrary to the physicians' judgement of what constitutes
      the patient's best interest on occasions when they are pressurised by next of
      kin. CONCLUSIONS: The study reveals a need to improve decision-making routines
      according to ethical ideals and legislation. Conflicts between relatives and
      healthcare professionals in the decision-making process deflect the focus from
      searching for the best possible treatment for the terminal patient. Further
      discussion is required as to whether the concept of autonomy is applicable in
      situations in which the patient is impaired and dying.
FAU - Dreyer, A
AU  - Dreyer A
AD  - Department of General Practice and Community Medicine, Aalesund University
      College/Section for Medical Ethics, University of Oslo, Bredelia 8, Aalesund
      6018, Norway. aod@hials.no
FAU - Forde, R
AU  - Forde R
FAU - Nortvedt, P
AU  - Nortvedt P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100616
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Adult
MH  - Attitude of Health Personnel
MH  - Clinical Competence
MH  - Decision Making/ethics
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Life Support Care/ethics/*standards
MH  - *Medical Staff/ethics/psychology
MH  - Middle Aged
MH  - Norway
MH  - *Nursing Homes
MH  - *Nursing Staff/ethics/psychology
MH  - Personal Autonomy
MH  - Professional-Family Relations
MH  - Surveys and Questionnaires
MH  - Terminal Care/ethics/*standards
EDAT- 2010/06/19 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/06/19 06:00
PHST- 2010/06/19 06:00 [entrez]
PHST- 2010/06/19 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - jme.2010.036244 [pii]
AID - 10.1136/jme.2010.036244 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Jul;36(7):396-400. doi: 10.1136/jme.2010.036244. Epub 2010 Jun
      16.


PMID- 20558435
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20101118
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 7
DP  - 2010 Jul
TI  - Whole-genome association studies for multigenic diseases: ethical dilemmas
      arising from commercialization--the case of genetic testing for autism.
PG  - 440-4
LID - 10.1136/jme.2009.031385 [doi]
AB  - This paper examines some ethical issues arising from whole-genome association
      studies for multigenic diseases, focusing on the case of autism. Events occurring
      following the announcement of a genetic test for autism in France (2005-2009) are
      described to exemplify the ethical controversies that can arise when genetic
      testing for autism is applied prematurely and inappropriately promoted by biotech
      companies. The authors argue that genetic tests assessing one or a few genes
      involved in highly multigenic disorders can only be useful if: (1) the genetic
      linkage found in the scientific study must be statistically convincing,
      reproducible and also applicable to the population to which the individual
      considered belongs (scientific validity); (2) the relative risk conferred by the 
      'high-risk' allele should be high enough to be significant to the patient
      (significant impact); (3) use of the test should lead to some improvement of
      outcome for the patient, resulting from adapted treatment if available, or at
      least from adjustment of lifestyle (or life goals) prompted by the new knowledge 
      generated (clinical utility). Decisions concerning genetic testing for autism
      involve scientific judgement, value judgement and good knowledge of a constantly 
      evolving therapeutic environment. The implementation of genetic tests for highly 
      multigenic diseases thus requires strong mechanisms to ensure that they are used 
      in a fashion that can benefit patients, and these mechanisms must be able to cope
      with rapid progress in scientific knowledge and therapeutic intervention.
FAU - Jordan, Bertrand R
AU  - Jordan BR
AD  - National Taiwan University College of Medicine and National Taiwan University
      Hospital, No 1, Section 1, Jen-Ai Rd, Taipei City 100, Taiwan. fctsai@ntu.edu.tw.
FAU - Tsai, Daniel Fu Chang
AU  - Tsai DF
LA  - eng
PT  - Journal Article
DEP - 20100616
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Autistic Disorder/*genetics
MH  - *Commerce
MH  - Genetic Linkage
MH  - Genetic Testing/*ethics
MH  - Genome-Wide Association Study/*ethics
MH  - Genomics/*ethics
MH  - Humans
EDAT- 2010/06/19 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/06/19 06:00
PHST- 2010/06/19 06:00 [entrez]
PHST- 2010/06/19 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - jme.2009.031385 [pii]
AID - 10.1136/jme.2009.031385 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Jul;36(7):440-4. doi: 10.1136/jme.2009.031385. Epub 2010 Jun
      16.


PMID- 20558385
OWN - NLM
STAT- MEDLINE
DCOM- 20100702
LR  - 20211020
IS  - 1538-3687 (Electronic)
IS  - 0003-9942 (Linking)
VI  - 67
IP  - 6
DP  - 2010 Jun
TI  - Stem cell model of spinal muscular atrophy.
PG  - 665-9
LID - 10.1001/archneurol.2010.89 [doi]
AB  - Human embryonic stem cells provide a useful source of material for studying basic
      human development and various disease states. However, ethical issues concerning 
      their procurement limit their acceptance and possible clinical applicability.
      Recent advances in stem cell technology have provided an alternative source of
      pluripotent stem cells that does not require the use of an embryo. This review
      addresses the generation of induced pluripotent stem cells from skin fibroblasts 
      taken from various patient populations, with a specific focus on the pediatric
      disorder spinal muscular atrophy. These patient-derived cells may help
      researchers devise more appropriate therapies through a greater understanding of 
      the molecular mechanisms that underlie neuron dysfunction and death in a variety 
      of diseases. Furthermore, they provide an ideal platform for small-molecule
      screening and subsequent drug development.
FAU - Ebert, Allison D
AU  - Ebert AD
AD  - Wisconsin Institutes for Medical Research, 1111 Highland Ave, Room 5033, Madison,
      WI 53705, USA. aebert@wisc.edu
FAU - Svendsen, Clive N
AU  - Svendsen CN
LA  - eng
GR  - P01 NS057778/NS/NINDS NIH HHS/United States
GR  - P01 NS057778-05/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Arch Neurol
JT  - Archives of neurology
JID - 0372436
SB  - IM
MH  - Animals
MH  - Cell Differentiation/physiology
MH  - Fibroblasts/cytology/metabolism
MH  - Humans
MH  - Muscular Atrophy, Spinal/*pathology/therapy
MH  - Pluripotent Stem Cells/*cytology/*physiology/transplantation
RF  - 33
PMC - PMC3140872
MID - NIHMS309431
EDAT- 2010/06/19 06:00
MHDA- 2010/07/06 06:00
CRDT- 2010/06/19 06:00
PHST- 2010/06/19 06:00 [entrez]
PHST- 2010/06/19 06:00 [pubmed]
PHST- 2010/07/06 06:00 [medline]
AID - 67/6/665 [pii]
AID - 10.1001/archneurol.2010.89 [doi]
PST - ppublish
SO  - Arch Neurol. 2010 Jun;67(6):665-9. doi: 10.1001/archneurol.2010.89.


PMID- 20558036
OWN - NLM
STAT- MEDLINE
DCOM- 20110113
LR  - 20101206
IS  - 1878-5921 (Electronic)
IS  - 0895-4356 (Linking)
VI  - 64
IP  - 1
DP  - 2011 Jan
TI  - Study design attributes influenced patients' willingness to participate in
      clinical research: a randomized vignette-based study.
PG  - 107-15
LID - 10.1016/j.jclinepi.2010.02.007 [doi]
AB  - OBJECTIVE: To identify characteristics of clinical research projects that
      influence patients' willingness to participate in research. STUDY DESIGN AND
      SETTING: We surveyed all patients discharged during 1 month from a Swiss public
      teaching hospital. We described four hypothetical studies and asked patients
      whether they would agree to participate. We randomly manipulated three study
      attributes in each vignette, using a factorial design. RESULTS: All studies were 
      not equally acceptable to the 1,277 respondents. A higher willingness to
      participate was found when a new drug had no side effects, no additional visit
      was required, balanced information was given, results were in the public domain, 
      and the project was approved by a research ethics committee. In contrast,
      destruction of blood samples at the end of the project, use of placebo controls, 
      and random allocation to study arms were associated with a lower likelihood of
      participation. The origin of funds, financial reward, the need to complete a
      questionnaire, and clinical vs. economic purpose of the study did not influence
      willingness to participate. CONCLUSION: Patients valued safety, convenience,
      oversight, and open communication in research. However, they were put off by some
      aspects that are valued by health care professionals. Educating the public about 
      research methods may improve participation.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Agoritsas, Thomas
AU  - Agoritsas T
AD  - Division of Clinical Epidemiology, University Hospitals of Geneva, Gabrielle
      Perret-Gentil 6, 1211 Geneva 14, Switzerland. thomas.agoritsas@hcuge.ch
FAU - Deom, Marie
AU  - Deom M
FAU - Perneger, Thomas V
AU  - Perneger TV
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20100616
PL  - United States
TA  - J Clin Epidemiol
JT  - Journal of clinical epidemiology
JID - 8801383
SB  - IM
MH  - Clinical Trials as Topic/*psychology
MH  - Data Collection
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Male
MH  - Motivation
MH  - Patient Participation/*psychology/statistics & numerical data
MH  - Research Design
MH  - Research Subjects/*psychology
EDAT- 2010/06/19 06:00
MHDA- 2011/01/14 06:00
CRDT- 2010/06/19 06:00
PHST- 2009/01/09 00:00 [received]
PHST- 2010/01/23 00:00 [revised]
PHST- 2010/02/05 00:00 [accepted]
PHST- 2010/06/19 06:00 [entrez]
PHST- 2010/06/19 06:00 [pubmed]
PHST- 2011/01/14 06:00 [medline]
AID - S0895-4356(10)00092-2 [pii]
AID - 10.1016/j.jclinepi.2010.02.007 [doi]
PST - ppublish
SO  - J Clin Epidemiol. 2011 Jan;64(1):107-15. doi: 10.1016/j.jclinepi.2010.02.007.
      Epub 2010 Jun 16.


PMID- 20558034
OWN - NLM
STAT- MEDLINE
DCOM- 20110111
LR  - 20151119
IS  - 1878-5921 (Electronic)
IS  - 0895-4356 (Linking)
VI  - 63
IP  - 12
DP  - 2010 Dec
TI  - Two prognostic indicators of the publication rate of clinical studies were
      available during ethical review.
PG  - 1342-50
LID - 10.1016/j.jclinepi.2010.01.018 [doi]
AB  - OBJECTIVE: To identify prognostic indicators of the publication rate of clinical 
      studies, available to research ethics committees (RECs) during review. STUDY
      DESIGN AND SETTING: Retrospective survival study of a random sample of 100
      studies, approved by a Dutch academic REC, with follow-up information by
      questionnaire and bibliographic searches. Multivariate Cox regression analysis of
      the association between publication rate and seven factors available during
      review: six study characteristics and the number of letters sent by the committee
      during review representing the length of the review process. RESULTS: Two factors
      were associated with publication rate: studies with possible therapeutic benefit 
      to participants were less likely to be published than nontherapeutic studies
      (adjusted hazard ratio [AHR]: 0.16; 95% confidence interval [CI]: 0.03-0.54);
      with every letter sent, publication was less likely (AHR: 0.46 per letter; 95%
      CI: 0.17-0.98). Possibly, studies with more-than-minimal burdens to participants 
      were more likely to be published than studies with minimal burdens (AHR: 3.90,
      95% CI: 1.03-16.64). CONCLUSION: We identified two prognostic indicators of
      publication rate. After suitable replication, RECs might explore using prognostic
      indicators, such as these, to target study protocols at high risk for
      nonpublication. Discussing the risk of nonpublication with investigators could
      help prevent nonpublication.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - de Jong, Jean Philippe
AU  - de Jong JP
AD  - Division of Clinical Methods and Public Health, Academic Medical Center,
      University of Amsterdam, Meibergdreef 15, Amsterdam, The Netherlands.
      j.ph.dejong@amc.uva.nl
FAU - Ter Riet, Gerben
AU  - Ter Riet G
FAU - Willems, Dick Ludolf
AU  - Willems DL
LA  - eng
PT  - Journal Article
DEP - 20100616
PL  - United States
TA  - J Clin Epidemiol
JT  - Journal of clinical epidemiology
JID - 8801383
SB  - IM
MH  - Biomedical Research
MH  - Clinical Protocols
MH  - Ethical Review
MH  - Ethics Committees, Research/ethics/*statistics & numerical data
MH  - Female
MH  - Forecasting
MH  - Humans
MH  - Male
MH  - Netherlands
MH  - Publication Bias/*statistics & numerical data
MH  - Retrospective Studies
MH  - Surveys and Questionnaires
EDAT- 2010/06/19 06:00
MHDA- 2011/01/12 06:00
CRDT- 2010/06/19 06:00
PHST- 2009/04/16 00:00 [received]
PHST- 2009/12/07 00:00 [revised]
PHST- 2010/01/12 00:00 [accepted]
PHST- 2010/06/19 06:00 [entrez]
PHST- 2010/06/19 06:00 [pubmed]
PHST- 2011/01/12 06:00 [medline]
AID - S0895-4356(10)00099-5 [pii]
AID - 10.1016/j.jclinepi.2010.01.018 [doi]
PST - ppublish
SO  - J Clin Epidemiol. 2010 Dec;63(12):1342-50. doi: 10.1016/j.jclinepi.2010.01.018.
      Epub 2010 Jun 16.


PMID- 20558027
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20151119
IS  - 1769-6623 (Electronic)
IS  - 0750-7658 (Linking)
VI  - 29
IP  - 6
DP  - 2010 Jun
TI  - [Withholding or withdrawing of life sustaining therapies in emergency context.
      Perception by anaesthesiologists].
PG  - 425-30
LID - 10.1016/j.annfar.2010.01.019 [doi]
AB  - OBJECTIVES: One objective is to state more accurately the difficulties met by the
      anaesthesiologists in an emergency context in case of withholding or withdrawing 
      life sustaining therapies. STUDY DESIGN AND PARTICIPANTS: A questionnaire
      addressed to anaesthesiologists of nine hospitals in the extreme West part of
      France. MATERIALS AND METHODS: The questionnaires were sent and returned by mail 
      in order to guarantee confidentiality. RESULTS: The participation rate was 40%
      with 172 questionnaires analysed. Ninety-eight per cent of the anaesthesiologists
      have already participated in a withholding or withdrawing life sustaining
      treatments, and in an emergency context in 92% of the cases. In that last case,
      criteria related to the severity of the clinic presentation and to the short-term
      death probability influence the decision made to interrupt life-sustaining
      therapies. For 93% of anaesthesiologists, the decision should be collegial, but
      50% of them had already made such a decision alone. The withdrawal of ventilatory
      support was the most difficult decision to make. Withdrawing mechanical
      ventilation or extubating appeared impossible for 23.4 and 50% of the
      anaesthesiologists respectively. Providing comfort care to the patients with end 
      of life decision was essential for 100% of the anaesthesiologists, but 11% of
      them used and considered analgesic and sedation after withholding or withdrawing 
      life sustaining treatments as euthanasia. The complaint possibility worried 57%
      of the anaesthesiologists and influenced the writing of the process or giving
      information to the families respectively for 65 and 75%. The righting of the
      medical files could be improved for 92% of the anaesthesiologists. CONCLUSION:
      The decision of withholding and withdrawing life sustaining treatments in an
      emergency context is based on the conviction of short-term death probability.
      Withholding and withdrawing life sustaining treatments is a decision made
      according to the principles of collegiality and necessary comfort cares, but the 
      procedure can still be improved, especially in the redaction of the medical file 
      and the ethical and juridical control of these extreme situations.
CI  - 2010 Elsevier Masson SAS. All rights reserved.
FAU - Dumont, R
AU  - Dumont R
AD  - Hopital Mere-Enfant, CHU, Hotel Dieu, Nantes, France. romain.dumont@chu-nantes.fr
FAU - Asehnoune, K
AU  - Asehnoune K
FAU - Pouplin, L
AU  - Pouplin L
FAU - Volteau, C
AU  - Volteau C
FAU - Simonneau, F
AU  - Simonneau F
FAU - Lejus, C
AU  - Lejus C
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Multicenter Study
TT  - Limitation ou arret de therapeutiques actives en situations d'urgence. Le point
      de vue des anesthesistes reanimateurs.
DEP - 20100616
PL  - France
TA  - Ann Fr Anesth Reanim
JT  - Annales francaises d'anesthesie et de reanimation
JID - 8213275
SB  - IM
MH  - *Anesthesiology
MH  - *Attitude of Health Personnel
MH  - *Emergencies
MH  - France
MH  - Humans
MH  - *Life Support Care
MH  - Surveys and Questionnaires
MH  - *Withholding Treatment
EDAT- 2010/06/19 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/06/19 06:00
PHST- 2009/02/20 00:00 [received]
PHST- 2010/01/13 00:00 [accepted]
PHST- 2010/06/19 06:00 [entrez]
PHST- 2010/06/19 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S0750-7658(10)00051-1 [pii]
AID - 10.1016/j.annfar.2010.01.019 [doi]
PST - ppublish
SO  - Ann Fr Anesth Reanim. 2010 Jun;29(6):425-30. doi: 10.1016/j.annfar.2010.01.019.
      Epub 2010 Jun 16.


PMID- 20557396
OWN - NLM
STAT- MEDLINE
DCOM- 20101129
LR  - 20191210
IS  - 1365-2648 (Electronic)
IS  - 0309-2402 (Linking)
VI  - 66
IP  - 8
DP  - 2010 Aug
TI  - Perceptions of conscience, stress of conscience and burnout among nursing staff
      in residential elder care.
PG  - 1708-18
LID - 10.1111/j.1365-2648.2010.05288.x [doi]
AB  - AIM: This paper is a report of a study of patterns of perceptions of conscience, 
      stress of conscience and burnout in relation to occupational belonging among
      Registered Nurses and nursing assistants in municipal residential care of older
      people. BACKGROUND: Stress and burnout among healthcare personnel and experiences
      of ethical difficulties are associated with troubled conscience. In elder care
      the experience of a troubled conscience seems to be connected to occupational
      role, but little is known about how Registered Nurses and nursing assistants
      perceive their conscience, stress of conscience and burnout. METHOD: Results of
      previous analyses of data collected in 2003, where 50 Registered Nurses and 96
      nursing assistants completed the Perceptions of Conscience Questionnaire, Stress 
      of Conscience Questionnaire and Maslach Burnout Inventory, led to a request for
      further analysis. In this study Partial Least Square Regression was used to
      detect statistical predictive patterns. RESULT: Perceptions of conscience and
      stress of conscience explained 41.9% of the variance in occupational belonging. A
      statistical predictive pattern for Registered Nurses was stress of conscience in 
      relation to falling short of expectations and demands and to perception of
      conscience as demanding sensitivity. A statistical predictive pattern for nursing
      assistants was perceptions that conscience is an authority and an asset in their 
      work. Burnout did not contribute to the explained variance in occupational
      belonging. CONCLUSION: Both occupational groups viewed conscience as an asset and
      not a burden. Registered Nurses seemed to exhibit sensitivity to expectations and
      demands and nursing assistants used their conscience as a source of guidance in
      their work. Structured group supervision with personnel from different
      occupations is needed so that staff can gain better understanding about their own
      occupational situation as well as the situation of other occupational groups.
FAU - Juthberg, Christina
AU  - Juthberg C
AD  - Department of Nursing, Umea University, Sweden. christina.juthberg@nurs.umu.se
FAU - Eriksson, Sture
AU  - Eriksson S
FAU - Norberg, Astrid
AU  - Norberg A
FAU - Sundin, Karin
AU  - Sundin K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100616
PL  - England
TA  - J Adv Nurs
JT  - Journal of advanced nursing
JID - 7609811
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Attitude of Health Personnel
MH  - Burnout, Professional/*psychology
MH  - Conflict, Psychological
MH  - *Conscience
MH  - Cross-Sectional Studies
MH  - Female
MH  - Geriatric Nursing/*ethics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nursing Assistants/*psychology
MH  - Nursing Homes/ethics
MH  - Nursing Staff/*psychology
MH  - Quality of Health Care/ethics
MH  - Surveys and Questionnaires
MH  - Sweden
MH  - Workload/psychology
EDAT- 2010/06/19 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/06/19 06:00
PHST- 2010/06/19 06:00 [entrez]
PHST- 2010/06/19 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - JAN5288 [pii]
AID - 10.1111/j.1365-2648.2010.05288.x [doi]
PST - ppublish
SO  - J Adv Nurs. 2010 Aug;66(8):1708-18. doi: 10.1111/j.1365-2648.2010.05288.x. Epub
      2010 Jun 16.


PMID- 20557382
OWN - NLM
STAT- MEDLINE
DCOM- 20101129
LR  - 20181201
IS  - 1365-2648 (Electronic)
IS  - 0309-2402 (Linking)
VI  - 66
IP  - 8
DP  - 2010 Aug
TI  - Use of unsolicited first-person written illness narratives in research:
      systematic review.
PG  - 1671-82
LID - 10.1111/j.1365-2648.2010.05349.x [doi]
AB  - AIM: This paper is a report of a methodological systematic review conducted to
      critically analyze the use of unsolicited first-person written illness narratives
      for research purposes. BACKGROUND: Documenting illness experiences through
      written narratives enables individuals to record the impact of illness on
      themselves and those closest to them. In health research, unsolicited
      first-person written illness narratives are recognized increasingly as legitimate
      data sources. To date there has been no critical evaluation of the method. DATA
      SOURCES: The ISI Web of Knowledge; CINAHL; PubMed; MEDLINE; PsycINFO; Science
      Direct; Cochrane Library databases and the internet metasearch engine 'Dogpile'
      were searched for the period up to 2009. The search terms were: 'patient
      experience', 'narratives', 'autobiography', 'pathography', 'written narratives', 
      'illness narratives', 'internet', 'published', 'unsolicited'. REVIEW METHODS:
      Recommendations within the Centre for Reviews and Dissemination guidance informed
      the review. Eligible studies were evaluated according to inclusion/exclusion
      criteria. The data were extracted by one reviewer and monitored by the second
      reviewer. FINDINGS: Eighteen papers met the inclusion criteria, 12 from the
      original search in 2008 and six from the updated search in October 2009. Nine
      used unpublished (internet) narratives, eight used published (print) accounts and
      one drew on both genres. The method has been used to explore a wide range of
      illness experiences. There was lack of agreement on key terminology.
      Methodological issues were often poorly-described, and confused ethical stances
      were reported. CONCLUSION: The lack of methodological detail in published papers 
      requires attention if this method is to be used effectively in healthcare
      research. The confused ethical stance adopted needs to be addressed and
      clarified. A theoretical conceptual framework to define and describe the method
      accurately is urgently required.
FAU - O'Brien, Mary R
AU  - O'Brien MR
AD  - Evidence-Based Practice Research Centre, Faculty of Health, Edge Hill University,
      Ormskirk, UK. obrienm@edgehill.ac.uk
FAU - Clark, David
AU  - Clark D
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20100616
PL  - England
TA  - J Adv Nurs
JT  - Journal of advanced nursing
JID - 7609811
SB  - IM
MH  - Access to Information/*ethics
MH  - Confidentiality/ethics
MH  - Cost of Illness
MH  - Databases as Topic
MH  - *Ethics, Research
MH  - Female
MH  - Humans
MH  - Internet/standards
MH  - Male
MH  - Medical History Taking/*methods
MH  - *Narration
MH  - Qualitative Research
MH  - *Writing
RF  - 37
EDAT- 2010/06/19 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/06/19 06:00
PHST- 2010/06/19 06:00 [entrez]
PHST- 2010/06/19 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - JAN5349 [pii]
AID - 10.1111/j.1365-2648.2010.05349.x [doi]
PST - ppublish
SO  - J Adv Nurs. 2010 Aug;66(8):1671-82. doi: 10.1111/j.1365-2648.2010.05349.x. Epub
      2010 Jun 16.


PMID- 20557141
OWN - NLM
STAT- MEDLINE
DCOM- 20101207
LR  - 20151119
IS  - 1535-3907 (Electronic)
IS  - 1535-3893 (Linking)
VI  - 9
IP  - 8
DP  - 2010 Aug 6
TI  - Practical analytical approach for the identification of biomarker candidates in
      prediabetic state based upon metabonomic study by ultraperformance liquid
      chromatography coupled to electrospray ionization time-of-flight mass
      spectrometry.
PG  - 3912-22
LID - 10.1021/pr100121k [doi]
AB  - The number of diabetic patients has recently been increasing worldwide. Thus, the
      discovery of potential diabetic biomarker(s), leading to the early detection
      and/or prevention of diabetes mellitus, is strongly required. The diagnosis of
      the prediabetic state in humans is a very difficult issue because of the
      lifestyle differences in each person and ethical consideration. Upon the basis of
      these considerations, animal experiments using ddY strain mice (ddY-H), which
      undergo naturally occurring diabetes along with age, were carried out in this
      study. Biomarker discovery based upon a metabonome study is now quite common, the
      same as that in the proteome analysis. Reversed-phase liquid chromatography-mass 
      spectrometry (LC-MS) has mainly been used for the extensive analysis of
      low-molecular mass compounds including metabolites. The metabolites in the plasma
      of diabetic mice (ddY-H) and normal mice (ddY-L) were exhaustively separated and 
      detected by ultraperformance liquid chromatography along with electrospray
      ionization time-of-flight mass spectrometry (UPLC-ESI-TOF-MS) using T3-C18 and
      HS-F5 columns. The biomarker candidates related to diabetes mellitus were
      extracted from the metabolite profiling of ddY-H and ddY-L at 5, 9 13, and 20
      weeks old using a multivariate statistical analysis such as orthogonal partial
      least-squares-discriminant analysis (OPLS-DA). Various metabolites and unknown
      compounds were detected as biomarker candidates related to diabetic mellitus.
      Furthermore, the concentration of several metabolites on Lysine biosynthesis and 
      Lysine degradation pathways were remarkably changed between the 9-week old ddY-H 
      and ddY-L mice. Because a couple of biomarker candidates related to the
      prediabetic state were identified using the present approach, the metabolite
      profiling study could be helpful for understanding the abnormal state of various 
      diseases.
FAU - Tsutsui, Haruhito
AU  - Tsutsui H
AD  - Laboratory of Analytical and Bio-Analytical Chemistry, Graduate School of
      Pharmaceutical Sciences, and Global COE Program, University of Shizuoka,
      Suruga-ku, Shizuoka, Japan.
FAU - Maeda, Toshio
AU  - Maeda T
FAU - Toyo'oka, Toshimasa
AU  - Toyo'oka T
FAU - Min, Jun Zhe
AU  - Min JZ
FAU - Inagaki, Shinsuke
AU  - Inagaki S
FAU - Higashi, Tatsuya
AU  - Higashi T
FAU - Kagawa, Yoshiyuki
AU  - Kagawa Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Proteome Res
JT  - Journal of proteome research
JID - 101128775
RN  - 0 (Biomarkers)
SB  - IM
MH  - Animals
MH  - Biomarkers/*analysis
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Diabetes Mellitus/*diagnosis
MH  - Discriminant Analysis
MH  - Metabolomics/*methods
MH  - Mice
MH  - Multivariate Analysis
MH  - Principal Component Analysis
MH  - Spectrometry, Mass, Electrospray Ionization/*methods
EDAT- 2010/06/19 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/06/19 06:00
PHST- 2010/06/19 06:00 [entrez]
PHST- 2010/06/19 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1021/pr100121k [doi]
PST - ppublish
SO  - J Proteome Res. 2010 Aug 6;9(8):3912-22. doi: 10.1021/pr100121k.


PMID- 20555022
OWN - NLM
STAT- MEDLINE
DCOM- 20100917
LR  - 20220408
IS  - 1946-6242 (Electronic)
IS  - 1946-6234 (Linking)
VI  - 2
IP  - 36
DP  - 2010 Jun 16
TI  - RNA-based gene therapy for HIV with lentiviral vector-modified CD34(+) cells in
      patients undergoing transplantation for AIDS-related lymphoma.
PG  - 36ra43
LID - 10.1126/scitranslmed.3000931 [doi]
AB  - AIDS patients who develop lymphoma are often treated with transplanted
      hematopoietic progenitor cells. As a first step in developing a hematopoietic
      cell-based gene therapy treatment, four patients undergoing treatment with these 
      transplanted cells were also given gene-modified peripheral blood-derived
      (CD34(+)) hematopoietic progenitor cells expressing three RNA-based anti-HIV
      moieties (tat/rev short hairpin RNA, TAR decoy, and CCR5 ribozyme). In vitro
      analysis of these gene-modified cells showed no differences in their
      hematopoietic potential compared with nontransduced cells. In vitro estimates of 
      successful expression of the anti-HIV moieties were initially as high as 22% but 
      declined to approximately 1% over 4 weeks of culture. Ethical study design
      required that patients be transplanted with both gene-modified and unmanipulated 
      hematopoietic progenitor cells obtained from the patient by apheresis.
      Transfected cells were successfully engrafted in all four infused patients by day
      11, and there were no unexpected infusion-related toxicities. Persistent vector
      expression in multiple cell lineages was observed at low levels for up to 24
      months, as was expression of the introduced small interfering RNA and ribozyme.
      Therefore, we have demonstrated stable vector expression in human blood cells
      after transplantation of autologous gene-modified hematopoietic progenitor cells.
      These results support the development of an RNA-based cell therapy platform for
      HIV.
FAU - DiGiusto, David L
AU  - DiGiusto DL
AD  - Department of Hematology and Hematopoietic Cell Transplantation, City of Hope,
      Duarte, CA 91010, USA.
FAU - Krishnan, Amrita
AU  - Krishnan A
FAU - Li, Lijing
AU  - Li L
FAU - Li, Haitang
AU  - Li H
FAU - Li, Shirley
AU  - Li S
FAU - Rao, Anitha
AU  - Rao A
FAU - Mi, Shu
AU  - Mi S
FAU - Yam, Priscilla
AU  - Yam P
FAU - Stinson, Sherri
AU  - Stinson S
FAU - Kalos, Michael
AU  - Kalos M
FAU - Alvarnas, Joseph
AU  - Alvarnas J
FAU - Lacey, Simon F
AU  - Lacey SF
FAU - Yee, Jiing-Kuan
AU  - Yee JK
FAU - Li, Mingjie
AU  - Li M
FAU - Couture, Larry
AU  - Couture L
FAU - Hsu, David
AU  - Hsu D
FAU - Forman, Stephen J
AU  - Forman SJ
FAU - Rossi, John J
AU  - Rossi JJ
FAU - Zaia, John A
AU  - Zaia JA
LA  - eng
GR  - AI61839/AI/NIAID NIH HHS/United States
GR  - M01 RR000043-49/RR/NCRR NIH HHS/United States
GR  - R01 HL074704/HL/NHLBI NIH HHS/United States
GR  - R37 AI029329/AI/NIAID NIH HHS/United States
GR  - HL07470/HL/NHLBI NIH HHS/United States
GR  - M01 RR00043/RR/NCRR NIH HHS/United States
GR  - P30 CA33572-26/CA/NCI NIH HHS/United States
GR  - S10RR025083-01/RR/NCRR NIH HHS/United States
GR  - P01 AI061839-04/AI/NIAID NIH HHS/United States
GR  - P50 CA107399-05/CA/NCI NIH HHS/United States
GR  - AI42552/AI/NIAID NIH HHS/United States
GR  - R01 AI042552-11/AI/NIAID NIH HHS/United States
GR  - P30 CA033572-29/CA/NCI NIH HHS/United States
GR  - M01 RR000043/RR/NCRR NIH HHS/United States
GR  - P01 AI061839/AI/NIAID NIH HHS/United States
GR  - R01 HL074704-07/HL/NHLBI NIH HHS/United States
GR  - P30 CA033572/CA/NCI NIH HHS/United States
GR  - R01 AI042552/AI/NIAID NIH HHS/United States
GR  - S10 RR025083/RR/NCRR NIH HHS/United States
GR  - S10 RR025083-01/RR/NCRR NIH HHS/United States
GR  - P50 CA107399/CA/NCI NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Sci Transl Med
JT  - Science translational medicine
JID - 101505086
RN  - 63231-63-0 (RNA)
SB  - IM
MH  - Adult
MH  - Female
MH  - Genetic Therapy/*methods
MH  - Genetic Vectors/*genetics
MH  - HIV Infections/*therapy
MH  - Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - Lymphoma, AIDS-Related/*therapy
MH  - Male
MH  - Middle Aged
MH  - RNA/*genetics
MH  - Treatment Outcome
PMC - PMC3130552
MID - NIHMS305014
EDAT- 2010/06/18 06:00
MHDA- 2010/09/21 06:00
CRDT- 2010/06/18 06:00
PHST- 2010/06/18 06:00 [entrez]
PHST- 2010/06/18 06:00 [pubmed]
PHST- 2010/09/21 06:00 [medline]
AID - 2/36/36ra43 [pii]
AID - 10.1126/scitranslmed.3000931 [doi]
PST - ppublish
SO  - Sci Transl Med. 2010 Jun 16;2(36):36ra43. doi: 10.1126/scitranslmed.3000931.


PMID- 20554429
OWN - NLM
STAT- MEDLINE
DCOM- 20110113
LR  - 20181201
IS  - 1878-5921 (Electronic)
IS  - 0895-4356 (Linking)
VI  - 64
IP  - 1
DP  - 2011 Jan
TI  - Are randomized trials conducted in China or India biased? A comparative empirical
      analysis.
PG  - 90-5
LID - 10.1016/j.jclinepi.2010.02.010 [doi]
AB  - CONTEXT: China and India are two emerging forces in undertaking randomized
      clinical trials. The quality of trials from these countries may affect not just
      their substantial populations but also their contribution to health policy
      throughout the world. OBJECTIVE: The objectives of this study were to describe
      and contrast the quality and biases in reports of trials conducted in China and
      India with a set of "gold standard" trials reported in leading European and North
      American journals. METHOD: A systematic review and comparative empirical analysis
      of randomized controlled trial reports published in selected Chinese, Indian, and
      European or North American medical journals were performed. Quality was assessed 
      against a subset of criteria from the CONSORT statement. We compared the rate of 
      reporting of positive outcomes in clinical trials to describe potential bias.
      RESULT: In total, 307 Chinese papers, 117 Indian papers, and 304 Western papers
      were included. Reports of Indian trials were slightly better than Chinese papers 
      on the trial reporting quality indicators and much better than Chinese papers on 
      reporting patients' ethical issues. However, the gold standard Western trial
      reports scored considerably higher on all quality criteria. Chinese papers were
      substantially more likely to report statistically significant results (odds ratio
      [OR]=2.96, 95% confidence interval [CI]=2.23-3.94; P<0.0001). Indian trials
      reported a similar rate of positive results to Western papers (OR=0.92, 95%
      CI=0.69-1.24; P=0.59). CONCLUSION: Reporting of trials in major Chinese and
      Indian journals falls short of that achieved in the gold standard Western
      journals we appraised and may reflect underlying inadequacies in the design and
      conduct of these trials. Chinese trials appear biased and may selectively report 
      positive outcomes while ignoring neutral or negative outcomes. Trialists and
      journal editors in China and India should adopt the CONSORT reporting guidelines,
      should ensure that a primary outcome is prespecified and reported, and should
      ensure that analysis is conducted according to the intention-to-treat principle. 
      Ethical questions in the conduct of trials in China must be addressed.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Zhang, Dalu
AU  - Zhang D
AD  - School of Health and Population Sciences, University of Birmingham, UK.
FAU - Freemantle, Nick
AU  - Freemantle N
FAU - Cheng, K K
AU  - Cheng KK
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20100615
PL  - United States
TA  - J Clin Epidemiol
JT  - Journal of clinical epidemiology
JID - 8801383
SB  - IM
CIN - J Clin Epidemiol. 2011 Aug;64(8):925-6. PMID: 21704256
MH  - China
MH  - Europe
MH  - Humans
MH  - India
MH  - Periodicals as Topic/*standards
MH  - *Publication Bias
MH  - Randomized Controlled Trials as Topic/methods/*standards
MH  - Reference Standards
EDAT- 2010/06/18 06:00
MHDA- 2011/01/14 06:00
CRDT- 2010/06/18 06:00
PHST- 2009/04/09 00:00 [received]
PHST- 2010/01/22 00:00 [revised]
PHST- 2010/02/01 00:00 [accepted]
PHST- 2010/06/18 06:00 [entrez]
PHST- 2010/06/18 06:00 [pubmed]
PHST- 2011/01/14 06:00 [medline]
AID - S0895-4356(10)00096-X [pii]
AID - 10.1016/j.jclinepi.2010.02.010 [doi]
PST - ppublish
SO  - J Clin Epidemiol. 2011 Jan;64(1):90-5. doi: 10.1016/j.jclinepi.2010.02.010. Epub 
      2010 Jun 15.


PMID- 20554067
OWN - NLM
STAT- MEDLINE
DCOM- 20101004
LR  - 20211020
IS  - 1873-2518 (Electronic)
IS  - 0264-410X (Linking)
VI  - 28
IP  - 32
DP  - 2010 Jul 19
TI  - The duty to treat in the context of an influenza pandemic.
PG  - 5260-4
LID - 10.1016/j.vaccine.2010.05.059 [doi]
AB  - The recent influenza pandemic proved that an influenza pandemic is no longer a
      future scenario. It may urge health care workers to undergo certain or even large
      risks. According to the WHO as well as commentators, a strong case can be made
      for adopting a duty to treat during a disease outbreak. Many current professional
      codes of ethics, however, fail to provide explicit guidance sufficient to set
      policy or assure the public in the event of an infectious disease outbreak. This 
      paper aims to assess whether there is a duty to treat in the case of an influenza
      pandemic. As we conclude that there are valid reasons that support the duty to
      treat in this specific context, we will subsequently explore its scope and
      limits.
CI  - (c) 2010 Elsevier Ltd. All rights reserved.
FAU - van der Weijden, C P
AU  - van der Weijden CP
AD  - University Medical Center Utrecht, Julius Center for Health Sciences and Primary 
      Care, Department of Medical Ethics, PO Box 85500, 3508 GA Utrecht, The
      Netherlands. cpvanderweijden@live.nl
FAU - Bredenoord, A L
AU  - Bredenoord AL
FAU - van Delden, J J M
AU  - van Delden JJ
LA  - eng
PT  - Journal Article
DEP - 20100608
PL  - Netherlands
TA  - Vaccine
JT  - Vaccine
JID - 8406899
SB  - IM
MH  - *Disease Outbreaks
MH  - *Ethics, Medical
MH  - Health Personnel/*ethics
MH  - Humans
MH  - Influenza, Human/epidemiology/*therapy
PMC - PMC7131753
EDAT- 2010/06/18 06:00
MHDA- 2010/10/05 06:00
CRDT- 2010/06/18 06:00
PHST- 2010/02/24 00:00 [received]
PHST- 2010/05/08 00:00 [revised]
PHST- 2010/05/24 00:00 [accepted]
PHST- 2010/06/18 06:00 [entrez]
PHST- 2010/06/18 06:00 [pubmed]
PHST- 2010/10/05 06:00 [medline]
AID - S0264-410X(10)00768-1 [pii]
AID - 10.1016/j.vaccine.2010.05.059 [doi]
PST - ppublish
SO  - Vaccine. 2010 Jul 19;28(32):5260-4. doi: 10.1016/j.vaccine.2010.05.059. Epub 2010
      Jun 8.


PMID- 20553811
OWN - NLM
STAT- MEDLINE
DCOM- 20101124
LR  - 20100806
IS  - 1532-3102 (Electronic)
IS  - 0143-4004 (Linking)
VI  - 31
IP  - 8
DP  - 2010 Aug
TI  - Ethical aspects of human placental perfusion: interview of the mothers donating
      placenta.
PG  - 686-90
LID - 10.1016/j.placenta.2010.05.005 [doi]
AB  - Within the EU project "NewGeneris" human placental perfusion has been used for
      assessing in utero fetal exposure to food carcinogens. Within the work package of
      ethical aspects of the research, we were interested in the way mothers who
      donated placentas for perfusion perceived their participation in the study.
      Thematic interviews were conducted with 25 mothers who had donated the placenta
      for placental perfusion studies. The main themes covered during the interviews
      were recruitment for placental perfusion studies, informed consent, risks and
      benefits, handling and confidentiality of personal information and societal
      meaning of the placental perfusion studies. Data were analysed qualitatively
      using thematic content analysis. Mothers, when rightly informed about the purpose
      of the placental perfusion study were very interested in the study and supported 
      the use of the placenta for such purpose. Overall, this study revealed several
      points of particular interest in placental perfusion studies. First, the
      recruiters' involvement with and commitment to the research project and its
      ethical conduct were of utmost importance for handling the informed consent
      procedure correctly. Second, the timing of the recruitment was important since it
      considerably affected the understanding of the given information, women in labour
      being obviously less receptive to such information. Third, the trust of
      participants depended on the multidisciplinary collaboration between the
      researchers and hospital personnel and this trust was enhanced by a thorough,
      objective and fair informed consent procedure.
FAU - Halkoaho, A
AU  - Halkoaho A
AD  - Faculty of Health Sciences, University of Eastern Finland, Research Unit,
      University Hospital of Kuopio, KYS, Research Ethics Committee, Kuopio, Finland.
      arja.halkoaho@kuh.fi
FAU - Pietila, A-M
AU  - Pietila AM
FAU - Dumez, B
AU  - Dumez B
FAU - Van Damme, K
AU  - Van Damme K
FAU - Heinonen, S
AU  - Heinonen S
FAU - Vahakangas, K
AU  - Vahakangas K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100609
PL  - Netherlands
TA  - Placenta
JT  - Placenta
JID - 8006349
SB  - IM
MH  - Adult
MH  - Confidentiality
MH  - Female
MH  - Humans
MH  - Informed Consent
MH  - Interviews as Topic
MH  - Male
MH  - Perfusion
MH  - *Placenta
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects
MH  - Risk Assessment
MH  - Tissue Donors/*ethics/psychology
MH  - Toxicity Tests
MH  - Young Adult
EDAT- 2010/06/18 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/06/18 06:00
PHST- 2010/03/29 00:00 [received]
PHST- 2010/05/12 00:00 [revised]
PHST- 2010/05/14 00:00 [accepted]
PHST- 2010/06/18 06:00 [entrez]
PHST- 2010/06/18 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S0143-4004(10)00201-8 [pii]
AID - 10.1016/j.placenta.2010.05.005 [doi]
PST - ppublish
SO  - Placenta. 2010 Aug;31(8):686-90. doi: 10.1016/j.placenta.2010.05.005. Epub 2010
      Jun 9.


PMID- 20553607
OWN - NLM
STAT- MEDLINE
DCOM- 20100729
LR  - 20211020
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 11
DP  - 2010 Jun 16
TI  - Malnutrition in elder care: qualitative analysis of ethical perceptions of
      politicians and civil servants.
PG  - 11
LID - 10.1186/1472-6939-11-11 [doi]
AB  - BACKGROUND: Few studies have paid attention to ethical responsibility related to 
      malnutrition in elder care. The aim was to illuminate whether politicians and
      civil servants reason about malnutrition in elder care in relation to ethical
      responsibility, and further about possible causes and how to address them.
      METHOD: Eighteen elected politicians and appointed civil servants at the
      municipality and county council level from two counties in Sweden were
      interviewed. They worked at a planning, control and executive level, with
      responsibility for both the elder care budget and quality of care. Qualitative
      method was used for the data analysis. RESULTS: Two themes emerged from their
      reasoning about malnutrition related to ethical responsibility. The theme assumed
      role involves the subthemes quality of care and costs, competent staff and govern
      at a distance. Old and ill patients were mentioned as being at risk for
      malnutrition. Caregivers were expected to be knowledgeable and stated primary
      responsible for providing adequate nutritional care. Extended physician
      responsibility was requested owing to patients' illnesses. Little was reported on
      the local management's role or on their own follow-up routines. The theme moral
      perception includes the subthemes discomfort, trust and distrust. Feelings of
      discomfort concerned caregivers having to work in a hurried, task-oriented
      manner. Trust meant that they believed for the most part that caregivers had the 
      competence to deal appropriately with nutritional care, but they felt distrust
      when nutritional problems reappeared on their agenda. No differences could be
      seen between the politicians and civil servants. CONCLUSION: New knowledge about 
      malnutrition in elder care related to ethical responsibility was illuminated by
      persons holding top positions. Malnutrition was stressed as an important
      dimension of the elder care quality. Governing at a distance meant having trust
      in the staff, on the one hand, and discomfort and distrust when confronted with
      reports of malnutrition, on the other. Distrust was directed at caregivers,
      because despite the fact that education had been provided, problems reappeared.
      Discomfort was felt when confronted with examples of poor nutritional care and
      indicates that the participants experienced failure in their ethical
      responsibility because the quality of nutritional care was at risk.
FAU - Mamhidir, Anna-Greta
AU  - Mamhidir AG
AD  - Department of Neurobiology, Caring Sciences and Society, Karolinska Institute,
      Stockholm, Sweden. anna-greta.mamhidir@hig.se
FAU - Kihlgren, Mona
AU  - Kihlgren M
FAU - Soerlie, Venke
AU  - Soerlie V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100616
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Administrative Personnel/*statistics & numerical data
MH  - Aged
MH  - Aged, 80 and over
MH  - Caregivers/*ethics
MH  - Female
MH  - Health Services for the Aged/*ethics
MH  - Home Care Services/ethics
MH  - Humans
MH  - Male
MH  - Malnutrition/*prevention & control
MH  - *Moral Obligations
MH  - Nurse Administrators/ethics
MH  - Politics
MH  - Qualitative Research
MH  - *Social Perception
MH  - *Social Responsibility
MH  - State Government
MH  - Surveys and Questionnaires
MH  - Sweden
MH  - *Trust
PMC - PMC2927875
EDAT- 2010/06/18 06:00
MHDA- 2010/07/30 06:00
CRDT- 2010/06/18 06:00
PHST- 2009/10/13 00:00 [received]
PHST- 2010/06/16 00:00 [accepted]
PHST- 2010/06/18 06:00 [entrez]
PHST- 2010/06/18 06:00 [pubmed]
PHST- 2010/07/30 06:00 [medline]
AID - 1472-6939-11-11 [pii]
AID - 10.1186/1472-6939-11-11 [doi]
PST - epublish
SO  - BMC Med Ethics. 2010 Jun 16;11:11. doi: 10.1186/1472-6939-11-11.


PMID- 20553586
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20220409
IS  - 1466-609X (Electronic)
IS  - 1364-8535 (Linking)
VI  - 14
IP  - 3
DP  - 2010
TI  - Intraoperative fluid optimization using stroke volume variation in high risk
      surgical patients: results of prospective randomized study.
PG  - R118
LID - 10.1186/cc9070 [doi]
AB  - INTRODUCTION: Stroke volume variation (SVV) is a good and easily obtainable
      predictor of fluid responsiveness, which can be used to guide fluid therapy in
      mechanically ventilated patients. During major abdominal surgery, inappropriate
      fluid management may result in occult organ hypoperfusion or fluid overload in
      patients with compromised cardiovascular reserves and thus increase postoperative
      morbidity. The aim of our study was to evaluate the influence of SVV guided fluid
      optimization on organ functions and postoperative morbidity in high risk patients
      undergoing major abdominal surgery. METHODS: Patients undergoing elective
      intraabdominal surgery were randomly assigned to a Control group (n = 60) with
      routine intraoperative care and a Vigileo group (n = 60), where fluid management 
      was guided by SVV (Vigileo/FloTrac system). The aim was to maintain the SVV below
      10% using colloid boluses of 3 ml/kg. The laboratory parameters of organ
      hypoperfusion in perioperative period, the number of infectious and organ
      complications on day 30 after the operation, and the hospital and ICU length of
      stay and mortality were evaluated. The local ethics committee approved the study.
      RESULTS: The patients in the Vigileo group received more colloid (1425 ml
      [1000-1500] vs. 1000 ml [540-1250]; P = 0.0028) intraoperatively and a lower
      number of hypotensive events were observed (2[1-2] Vigileo vs. 3.5[2-6] in
      Control; P = 0.0001). Lactate levels at the end of surgery were lower in Vigileo 
      (1.78 +/- 0.83 mmol/l vs. 2.25 +/- 1.12 mmol/l; P = 0.0252). Fewer Vigileo
      patients developed complications (18 (30%) vs. 35 (58.3%) patients; P = 0.0033)
      and the overall number of complications was also reduced (34 vs. 77 complications
      in Vigileo and Control respectively; P = 0.0066). A difference in hospital length
      of stay was found only in per protocol analysis of patients receiving
      optimization (9 [8-12] vs. 10 [8-19] days; P = 0.0421). No difference in
      mortality (1 (1.7%) vs. 2 (3.3%); P = 1.0) and ICU length of stay (3 [2-5] vs. 3 
      [0.5-5]; P = 0.789) was found. CONCLUSIONS: In this study, fluid optimization
      guided by SVV during major abdominal surgery is associated with better
      intraoperative hemodynamic stability, decrease in serum lactate at the end of
      surgery and lower incidence of postoperative organ complications. TRIAL
      REGISTRATION: Current Controlled Trials ISRCTN95085011.
FAU - Benes, Jan
AU  - Benes J
AD  - Department of Anesthesiology and Intensive Care, Charles University teaching
      hospital, alej Svobody 80, Plzen 304 60, Czech Republic. benesj@fnplzen.cz
FAU - Chytra, Ivan
AU  - Chytra I
FAU - Altmann, Pavel
AU  - Altmann P
FAU - Hluchy, Marek
AU  - Hluchy M
FAU - Kasal, Eduard
AU  - Kasal E
FAU - Svitak, Roman
AU  - Svitak R
FAU - Pradl, Richard
AU  - Pradl R
FAU - Stepan, Martin
AU  - Stepan M
LA  - eng
SI  - ISRCTN/ISRCTN95085011
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20100616
PL  - England
TA  - Crit Care
JT  - Critical care (London, England)
JID - 9801902
SB  - IM
CIN - Crit Care. 2010;14(4):177. PMID: 20670387
CIN - Crit Care. 2011;15(6):460. PMID: 22189038
MH  - Abdomen/surgery
MH  - Aged
MH  - Female
MH  - Fluid Therapy/*methods
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Monitoring, Intraoperative/*methods
MH  - Postoperative Complications/prevention & control
MH  - Prospective Studies
MH  - Respiration, Artificial
MH  - Risk Management
MH  - Stroke Volume/*physiology
MH  - Surgical Procedures, Operative
MH  - Water-Electrolyte Balance
PMC - PMC2911766
EDAT- 2010/06/18 06:00
MHDA- 2011/01/07 06:00
CRDT- 2010/06/18 06:00
PHST- 2010/01/12 00:00 [received]
PHST- 2010/05/04 00:00 [revised]
PHST- 2010/06/16 00:00 [accepted]
PHST- 2010/06/18 06:00 [entrez]
PHST- 2010/06/18 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
AID - cc9070 [pii]
AID - 10.1186/cc9070 [doi]
PST - ppublish
SO  - Crit Care. 2010;14(3):R118. doi: 10.1186/cc9070. Epub 2010 Jun 16.


PMID- 20553449
OWN - NLM
STAT- MEDLINE
DCOM- 20100922
LR  - 20100617
IS  - 1600-6143 (Electronic)
IS  - 1600-6135 (Linking)
VI  - 10
IP  - 6
DP  - 2010 Jun
TI  - Ethical considerations for participation of nondirected living donors in kidney
      exchange programs.
PG  - 1460-7
LID - 10.1111/j.1600-6143.2010.03136.x [doi]
AB  - Kidneys from nondirected donors (NDDs) have historically been allocated directly 
      to the deceased donor wait list (DDWL). Recently, however, NDDs have participated
      in kidney exchange (KE) procedures, including KE 'chains', which have received
      considerable media attention. This increasing application of KE chains with NDD
      participation has occurred with limited ethical analysis and without ethical
      guidelines. This article aims to provide a rigorous ethical evaluation of NDDs
      and chain KEs. NDDs and bridge donors (BDs) (i.e. living donors who link KE
      procedures within KE chains) raise several ethical concerns including coercion,
      privacy, confidentiality, exploitation and commercialization. In addition,
      although NDD participation in KE procedures may increase transplant numbers, it
      may also reduce NDD kidney allocation to the DDWL, and disadvantage vulnerable
      populations, particularly O blood group candidates. Open KE chains (also termed
      'never-ending' chains) result in a permanent diversion of NDD kidneys from the
      DDWL. The concept of limited KE chains is discussed as an ethically preferable
      means for protecting NDDs and BDs from coercion and minimizing 'backing out',
      whereas 'honor systems' are rejected because they are coercive and override
      autonomy. Recent occurrences of BDs backing out argue for adoption of ethically
      based protective measures for NDD participation in KE.
FAU - Woodle, E S
AU  - Woodle ES
AD  - The Paired Donation Network, Orlando, FL, USA. woodlees@uc.edu
FAU - Daller, J A
AU  - Daller JA
FAU - Aeder, M
AU  - Aeder M
FAU - Shapiro, R
AU  - Shapiro R
FAU - Sandholm, T
AU  - Sandholm T
FAU - Casingal, V
AU  - Casingal V
FAU - Goldfarb, D
AU  - Goldfarb D
FAU - Lewis, R M
AU  - Lewis RM
FAU - Goebel, J
AU  - Goebel J
FAU - Siegler, M
AU  - Siegler M
CN  - Paired Donation Network
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
SB  - IM
CIN - Am J Transplant. 2010 Jun;10(6):1345-6. PMID: 20553446
MH  - Communication
MH  - Communications Media
MH  - Confidentiality
MH  - Ethical Analysis
MH  - Humans
MH  - Kidney/*immunology
MH  - *Living Donors
MH  - Tissue Donors
MH  - Waiting Lists
EDAT- 2010/06/18 06:00
MHDA- 2010/09/24 06:00
CRDT- 2010/06/18 06:00
PHST- 2010/06/18 06:00 [entrez]
PHST- 2010/06/18 06:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
AID - AJT3136 [pii]
AID - 10.1111/j.1600-6143.2010.03136.x [doi]
PST - ppublish
SO  - Am J Transplant. 2010 Jun;10(6):1460-7. doi: 10.1111/j.1600-6143.2010.03136.x.


PMID- 20552941
OWN - NLM
STAT- MEDLINE
DCOM- 20100722
LR  - 20100617
IS  - 1320-159X (Print)
IS  - 1320-159X (Linking)
VI  - 17
IP  - 5
DP  - 2010 May
TI  - Sugar, ethics and legislation.
PG  - 784-99
AB  - There are serious ethical and legal issues concerning the sale of sugar products,
      especially to children, yet one cannot address children's consumption without
      addressing consumption across society. The ethical principles are not even
      controversial. However, sugar has been insufficiently scrutinised, probably
      because sweetness is popular and plays a prominent, but dispensable, cultural
      role. Sugar is both addictive and toxic, although it is a very mild, very
      slow-working poison. Yet, over time, its effects can be quite serious. The social
      and health problems have proved grave and intractable. Given the nature of sugar,
      it should be regulated like alcohol and tobacco, if not more stringently, given
      its greater social and cultural penetration across all ages. That is, sales of
      sugar products at school canteens should be banned, advertising severely limited,
      full disclosure of sugar content made mandatory, warnings placed on certain
      products, and sugar itself should be taxed.
FAU - Azize, Joseph
AU  - Azize J
AD  - Faculty of Law, University of Technology, Sydney. Joseph.Azize@uts.edu.au
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Law Med
JT  - Journal of law and medicine
JID - 9431853
RN  - 0 (Dietary Sucrose)
SB  - IM
MH  - Australia
MH  - *Dietary Sucrose
MH  - *Government Regulation
MH  - Health Policy
MH  - Humans
MH  - Public Health/*legislation & jurisprudence
MH  - Social Control, Informal
EDAT- 2010/06/18 06:00
MHDA- 2010/07/23 06:00
CRDT- 2010/06/18 06:00
PHST- 2010/06/18 06:00 [entrez]
PHST- 2010/06/18 06:00 [pubmed]
PHST- 2010/07/23 06:00 [medline]
PST - ppublish
SO  - J Law Med. 2010 May;17(5):784-99.


PMID- 20552940
OWN - NLM
STAT- MEDLINE
DCOM- 20100722
LR  - 20100617
IS  - 1320-159X (Print)
IS  - 1320-159X (Linking)
VI  - 17
IP  - 5
DP  - 2010 May
TI  - Greening Australia's public health system: the role of public hospitals in
      responding to climate change.
PG  - 772-83
AB  - Climate change is one of the most important social, economic, ecological and
      ethical issues of the 21st century. The effects of climate change on human health
      are now widely accepted as a genuine threat and the Australian Government has
      initiated policy and legislative responses. In addition, in the 2009-2010 budget 
      the Australian Government has committed A$64 billion to public health and
      hospital reform. But will this Commonwealth funding support--and should it
      support--the government's high-profile climate change policy? Does Commonwealth
      funding translate to an obligation to support Commonwealth policies? This article
      explores the role of public hospitals as champions and role models of the
      Australian Government's climate change policy and how this might be done without 
      detracting from the primary purpose of public hospital funding: improving patient
      care.
FAU - Primozic, Lauren
AU  - Primozic L
AD  - lauren_p7@hotmail.com
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Law Med
JT  - Journal of law and medicine
JID - 9431853
SB  - IM
MH  - Australia
MH  - *Climate Change
MH  - Financing, Government
MH  - Hospitals, Public/*economics
MH  - Humans
MH  - *Policy Making
EDAT- 2010/06/18 06:00
MHDA- 2010/07/23 06:00
CRDT- 2010/06/18 06:00
PHST- 2010/06/18 06:00 [entrez]
PHST- 2010/06/18 06:00 [pubmed]
PHST- 2010/07/23 06:00 [medline]
PST - ppublish
SO  - J Law Med. 2010 May;17(5):772-83.


PMID- 20552937
OWN - NLM
STAT- MEDLINE
DCOM- 20100722
LR  - 20100617
IS  - 1320-159X (Print)
IS  - 1320-159X (Linking)
VI  - 17
IP  - 5
DP  - 2010 May
TI  - Swine flu, doctors and pandemics: is there a duty to treat during a pandemic?
PG  - 736-47
AB  - The swine influenza (H1N1) outbreak in 2009 highlighted the ethical and legal
      pressures facing general practitioners and health workers in emergency
      departments in determining the nature and limits of their obligations to their
      patients and the public. Health workers require guidance on the multiple,
      overlapping, and at times conflicting legal and ethical duties owed to patients
      and prospective patients, employers and fellow health workers, and their
      families. Existing sources of advice on these issues in Australia, by way of
      statements of medical ethics and other sources of advice, are shown to be in need
      of further amplification if health workers are to be provided with the certainty 
      and guidance required. Given the complexity of the issues, Australia would
      therefore benefit from more extensive consultation with the variety of
      stakeholders involved in these questions if pandemic plans are to smoothly deal
      with future crises in an ethically and legally sound manner.
FAU - Bennett, Belinda
AU  - Bennett B
AD  - Law School Building (F10), Eastern Avenue, Camperdown Campus, The University of
      Sydney, NSW 2006, Australia. Belinda.Bennett@Sydney.edu.au
FAU - Carney, Terry
AU  - Carney T
FAU - Saint, Caroline
AU  - Saint C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - J Law Med
JT  - Journal of law and medicine
JID - 9431853
SB  - IM
MH  - Australia
MH  - *Disease Outbreaks
MH  - Health Personnel/*legislation & jurisprudence
MH  - Humans
MH  - *Influenza A Virus, H1N1 Subtype
MH  - Influenza, Human/epidemiology
MH  - Refusal to Treat/*legislation & jurisprudence
MH  - Severe Acute Respiratory Syndrome/epidemiology
EDAT- 2010/06/18 06:00
MHDA- 2010/07/23 06:00
CRDT- 2010/06/18 06:00
PHST- 2010/06/18 06:00 [entrez]
PHST- 2010/06/18 06:00 [pubmed]
PHST- 2010/07/23 06:00 [medline]
PST - ppublish
SO  - J Law Med. 2010 May;17(5):736-47.


PMID- 20552935
OWN - NLM
STAT- MEDLINE
DCOM- 20100722
LR  - 20181201
IS  - 1320-159X (Print)
IS  - 1320-159X (Linking)
VI  - 17
IP  - 5
DP  - 2010 May
TI  - Regulation of vitamin and mineral supplements: lessons from the Truehope saga.
PG  - 719-28
AB  - A series of court and regulatory hearings has characterised the distribution and 
      promotion in Canada of Empower Plus, a vitamin and mineral supplement promoted by
      its distributors as efficacious for a remarkable array of psychiatric conditions,
      including bipolar disorder and schizophrenia. The column chronicles the saga and 
      the multiple ethical and scientific concerns that arise from it. It argues that, 
      given the risks posed to the vulnerable by supplements constituted by
      micronutrients that may uninformedly be seen as a viable alternative to orthodox 
      pharmacotherapies, none of which are panaceas, supplements should be subjected to
      rigorous medico-scientific assessment and regulation. It laments the too rare
      institution of consumer protection actions brought in an effort to protect the
      public in such scenarios.
FAU - Freckelton, Ian
AU  - Freckelton I
AD  - Law Faculty, Department of Psychology, Psychiatry and Psychological Medicine,
      Monash University, Australia. I.Freckelton@vicbar.com.au
LA  - eng
PT  - Journal Article
PT  - Legal Case
PL  - Australia
TA  - J Law Med
JT  - Journal of law and medicine
JID - 9431853
RN  - 0 (Vitamins)
SB  - IM
MH  - Australia
MH  - *Dietary Supplements
MH  - Humans
MH  - *Legislation, Drug
MH  - Vitamins/therapeutic use
EDAT- 2010/06/18 06:00
MHDA- 2010/07/23 06:00
CRDT- 2010/06/18 06:00
PHST- 2010/06/18 06:00 [entrez]
PHST- 2010/06/18 06:00 [pubmed]
PHST- 2010/07/23 06:00 [medline]
PST - ppublish
SO  - J Law Med. 2010 May;17(5):719-28.


PMID- 20552933
OWN - NLM
STAT- MEDLINE
DCOM- 20100722
LR  - 20181201
IS  - 1320-159X (Print)
IS  - 1320-159X (Linking)
VI  - 17
IP  - 5
DP  - 2010 May
TI  - Regulation of biomedical products.
PG  - 701-7
AB  - Two recent decisions, one from Australia and one from Canada, should cause us to 
      examine the ethical issues surrounding the regulation of biomedical products. The
      protection of vulnerable consumers from variable quality and poorly prepared
      drugs with uncertain parameters of safety and efficacy is a priority for any
      community and should not have to be weighed against possible costs based on
      restrictions of trade. However, the possibility of an environment in which the
      multinational biomedical industry edges out any other players in the treatment of
      various illnesses has its own dangers. Not least is the apparent collusion
      between regulators and industry that ramps up the costs and intensity of
      licensing and risk management so that only an industry-type budget can sustain
      the costs of compliance. This has the untoward effect of delivering contemporary 
      health care into the hands of those who make immense fortunes out of it. An
      approach to regulation that tempers bureaucratic mechanisms with a dose of common
      sense and realistic evidence-based risk assessment could go a long way in
      avoiding the Scylla and Charybdis awaiting the clinical world in these troubled
      waters.
FAU - Gillett, Grant
AU  - Gillett G
AD  - Dunedin Hospital and Otago Bioethics Centre, University of Otago Medical School, 
      New Zealand. grant.gillett@stonebow.otago.ac.nz
FAU - Saville-Cook, Donald
AU  - Saville-Cook D
LA  - eng
PT  - Journal Article
PT  - Legal Case
PL  - Australia
TA  - J Law Med
JT  - Journal of law and medicine
JID - 9431853
SB  - IM
MH  - Australia
MH  - Canada
MH  - Consumer Product Safety/legislation & jurisprudence
MH  - *Dietary Supplements
MH  - *Government Regulation
MH  - Humans
MH  - *Legislation, Drug
MH  - *Liability, Legal
EDAT- 2010/06/18 06:00
MHDA- 2010/07/23 06:00
CRDT- 2010/06/18 06:00
PHST- 2010/06/18 06:00 [entrez]
PHST- 2010/06/18 06:00 [pubmed]
PHST- 2010/07/23 06:00 [medline]
PST - ppublish
SO  - J Law Med. 2010 May;17(5):701-7.


PMID- 20552931
OWN - NLM
STAT- MEDLINE
DCOM- 20100722
LR  - 20100617
IS  - 1320-159X (Print)
IS  - 1320-159X (Linking)
VI  - 17
IP  - 5
DP  - 2010 May
TI  - Healthcare Identifiers legislation: a whiff of fourberie.
PG  - 660-76
AB  - The Healthcare Identifiers Bill 2010 (Cth), which will establish "the national
      e-health Healthcare Identifiers Service to provide that patients, healthcare
      providers and provider organisations can be consistently identified", is in the
      process of being enacted by the Australian Federal Parliament. The legislation
      will enable the government to assign to each "healthcare recipient" a 26-digit
      electronic "Healthcare Identifier", which will be accessible, with or without the
      recipient's consent, to a broad range of health care service providers as well as
      other entities. The individual Healthcare Identifier file will initially contain 
      such identifying information as, where applicable, the Medicare number and/or the
      Veterans' Affairs number; name; address; gender; date of birth; and "the date of 
      birth accuracy indicator" presumably birth certificate. However, since each
      "service" provided by a health care provider to a health care recipient will be
      automatically recorded on each individual's Healthcare Identifier file, in time
      these electronic files should contain a full record of such services or contacts.
      Moreover, the Healthcare Identifiers are considered a "key" to, or a "foundation 
      stone" for, the implementation of the shared electronic health records scheme,
      because they will enable linkage with and retrieval of each patient's clinical
      records throughout the health care service system. However, there has been
      virtually no discussion about the legal, ethical and social implications of this 
      legislation.
FAU - Mendelson, Danuta
AU  - Mendelson D
AD  - School of Law, Deakin University. danuta.mendelson@deakin.edu.au
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Law Med
JT  - Journal of law and medicine
JID - 9431853
SB  - IM
MH  - Australia
MH  - Confidentiality/legislation & jurisprudence
MH  - Forms and Records Control
MH  - Humans
MH  - *Medical Records Systems, Computerized
MH  - Patient Identification Systems/*legislation & jurisprudence/*methods
EDAT- 2010/06/18 06:00
MHDA- 2010/07/23 06:00
CRDT- 2010/06/18 06:00
PHST- 2010/06/18 06:00 [entrez]
PHST- 2010/06/18 06:00 [pubmed]
PHST- 2010/07/23 06:00 [medline]
PST - ppublish
SO  - J Law Med. 2010 May;17(5):660-76.


PMID- 20552570
OWN - NLM
STAT- MEDLINE
DCOM- 20110131
LR  - 20100621
IS  - 1097-0258 (Electronic)
IS  - 0277-6715 (Linking)
VI  - 29
IP  - 15
DP  - 2010 Jul 10
TI  - Sample size calculations for evaluating a diagnostic test when the gold standard 
      is missing at random.
PG  - 1572-9
LID - 10.1002/sim.3899 [doi]
AB  - Performance of a diagnostic test is ideally evaluated by a comparison of the test
      results to a gold standard for all the patients in a study. In practice, however,
      it is common for a subset of study patients to have the gold standard not
      verified (missing) due to ethical or expense considerations. Sensitivity and
      specificity are often used as the relevant test performance measures and a joint 
      confidence region (CR) for sensitivity and specificity can summarize the
      precision of estimates. In this paper, we present an approach to sample size
      computations when designing a study in which the gold standard is considered to
      be missing at random (MAR). We calculate the needed increase in sample size to
      ensure that the joint CR under MAR falls inside the boundaries of the joint CR
      derived for data with no missingness present.
CI  - Copyright 2010 John Wiley & Sons, Ltd.
FAU - Kosinski, Andrzej S
AU  - Kosinski AS
AD  - Department of Biostatistics and Bioinformatics, Duke University Medical Center,
      Duke Clinical Research Institute, P. O. Box 17969, Durham, NC 27715, USA.
      andrzej.kosinski@duke.edu
FAU - Chen, Ying
AU  - Chen Y
FAU - Lyles, Robert H
AU  - Lyles RH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Stat Med
JT  - Statistics in medicine
JID - 8215016
RN  - EC 3.4.21.77 (Prostate-Specific Antigen)
SB  - IM
CIN - Stat Med. 2010 Oct 30;29(24):2568. PMID: 20954220
MH  - Algorithms
MH  - Biostatistics/*methods
MH  - Computer Simulation
MH  - Confidence Intervals
MH  - Data Interpretation, Statistical
MH  - *Diagnostic Tests, Routine/methods
MH  - Humans
MH  - Male
MH  - Prostate-Specific Antigen/blood
MH  - Prostatic Neoplasms/blood/diagnosis/pathology
MH  - Sample Size
MH  - Sensitivity and Specificity
EDAT- 2010/06/17 06:00
MHDA- 2011/02/01 06:00
CRDT- 2010/06/17 06:00
PHST- 2010/06/17 06:00 [entrez]
PHST- 2010/06/17 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
AID - 10.1002/sim.3899 [doi]
PST - ppublish
SO  - Stat Med. 2010 Jul 10;29(15):1572-9. doi: 10.1002/sim.3899.


PMID- 20552507
OWN - NLM
STAT- MEDLINE
DCOM- 20100928
LR  - 20100616
IS  - 1532-7752 (Electronic)
IS  - 0022-3891 (Linking)
VI  - 92
IP  - 4
DP  - 2010 Jul
TI  - National survey of psychologists' test feedback training, supervision, and
      practice: a mixed methods study.
PG  - 327-36
LID - 10.1080/00223891.2010.482006 [doi]
AB  - In this empirical, mixed methods study, we explored test feedback training,
      supervision, and practice among psychologists, focusing specifically on how
      feedback is provided to clients and whether feedback skills are taught in
      graduate programs. Based on a 48.5% return rate, this national survey of
      clinical, counseling, and school psychologists' suggests psychologists provide
      test feedback to clients but inconsistently. Most respondents, 91.7%, indicated
      they give verbal feedback at least some of the time, whereas 35% do so every
      time. However, 2.8% indicated they never give feedback. A negative correlation
      exists for clinical psychologists between years since graduation and providing
      verbal feedback. Of particular interest, approximately one third of respondents
      indicated predoctoral coursework, practica, and internship were of little-to-no
      help in preparing them to provide feedback. Also, feedback training in
      predoctoral coursework, practica, and internship was not correlated to actually
      providing feedback. There was, however, a significant correlation between
      postdoctoral training and providing feedback. Consistent with existing ethical
      exceptions, the most frequent reason for not providing feedback was using
      assessments in forensic settings. Individuals who indicated their training was
      not helpful cited "trial and error" and self-instruction as ways in which they
      learned feedback skills. We discuss implications and suggestions for feedback
      training, research, and practice.
FAU - Curry, Kyle T
AU  - Curry KT
AD  - Department of Educational Psychology, University of Nebraska-Lincoln, USA.
      kyle.curry@va.gov
FAU - Hanson, William E
AU  - Hanson WE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Pers Assess
JT  - Journal of personality assessment
JID - 1260201
SB  - IM
MH  - Data Collection
MH  - Education, Graduate
MH  - *Feedback
MH  - Female
MH  - Humans
MH  - Male
MH  - Professional-Patient Relations
MH  - *Psychological Tests
MH  - Psychology/*education
MH  - United States
EDAT- 2010/06/17 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/06/17 06:00
PHST- 2010/06/17 06:00 [entrez]
PHST- 2010/06/17 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - 923044968 [pii]
AID - 10.1080/00223891.2010.482006 [doi]
PST - ppublish
SO  - J Pers Assess. 2010 Jul;92(4):327-36. doi: 10.1080/00223891.2010.482006.


PMID- 20552254
OWN - NLM
STAT- MEDLINE
DCOM- 20101221
LR  - 20211020
IS  - 1573-904X (Electronic)
IS  - 0724-8741 (Linking)
VI  - 27
IP  - 9
DP  - 2010 Sep
TI  - Publication ethics--a guide for submitting manuscripts to Pharmaceutical
      Research.
PG  - 1757-8
LID - 10.1007/s11095-010-0188-5 [doi]
FAU - Swaan, Peter W
AU  - Swaan PW
LA  - eng
PT  - Editorial
DEP - 20100615
PL  - United States
TA  - Pharm Res
JT  - Pharmaceutical research
JID - 8406521
SB  - IM
MH  - *Biomedical Research/ethics/standards
MH  - Duplicate Publications as Topic
MH  - Editorial Policies
MH  - *Pharmacology/ethics/standards
MH  - *Plagiarism
MH  - *Publishing/ethics/standards
EDAT- 2010/06/17 06:00
MHDA- 2010/12/22 06:00
CRDT- 2010/06/17 06:00
PHST- 2010/06/02 00:00 [received]
PHST- 2010/06/03 00:00 [accepted]
PHST- 2010/06/17 06:00 [entrez]
PHST- 2010/06/17 06:00 [pubmed]
PHST- 2010/12/22 06:00 [medline]
AID - 10.1007/s11095-010-0188-5 [doi]
PST - ppublish
SO  - Pharm Res. 2010 Sep;27(9):1757-8. doi: 10.1007/s11095-010-0188-5. Epub 2010 Jun
      15.


PMID- 20551243
OWN - NLM
STAT- MEDLINE
DCOM- 20100928
LR  - 20220330
IS  - 1758-1117 (Electronic)
IS  - 0023-6772 (Linking)
VI  - 44
IP  - 3
DP  - 2010 Jul
TI  - Enhancing search efficiency by means of a search filter for finding all studies
      on animal experimentation in PubMed.
PG  - 170-5
LID - 10.1258/la.2010.009117 [doi]
AB  - Collecting and analysing all available literature before starting an animal
      experiment is important and it is indispensable when writing a systematic review 
      (SR) of animal research. Writing such review prevents unnecessary duplication of 
      animal studies and thus unnecessary animal use (Reduction). One of the factors
      currently impeding the production of 'high-quality' SRs in laboratory animal
      science is the fact that searching for all available literature concerning animal
      experimentation is rather difficult. In order to diminish these difficulties, we 
      developed a search filter for PubMed to detect all publications concerning animal
      studies. This filter was compared with the method most frequently used, the
      PubMed Limit: Animals, and validated further by performing two PubMed topic
      searches. Our filter performs much better than the PubMed limit: it retrieves, on
      average, 7% more records. Other important advantages of our filter are that it
      also finds the most recent records and that it is easy to use. All in all, by
      using our search filter in PubMed, all available literature concerning animal
      studies on a specific topic can easily be found and assessed, which will help in 
      increasing the scientific quality and thereby the ethical validity of animal
      experiments.
FAU - Hooijmans, Carlijn R
AU  - Hooijmans CR
AD  - Radboud University Nijmegen Medical Centre, Central Animal Laboratory and 3R
      Research Centre, Geert Grooteplein Noord 29, Route 231, Nijmegen, The
      Netherlands. C.Hooijmans@cdl.umcn.nl
FAU - Tillema, Alice
AU  - Tillema A
FAU - Leenaars, Marlies
AU  - Leenaars M
FAU - Ritskes-Hoitinga, Merel
AU  - Ritskes-Hoitinga M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100615
PL  - England
TA  - Lab Anim
JT  - Laboratory animals
JID - 0112725
SB  - IM
MH  - Abstracting and Indexing/methods
MH  - *Animal Experimentation
MH  - *Animal Use Alternatives
MH  - Animal Welfare
MH  - Animals
MH  - Animals, Laboratory
MH  - Biomedical Research/*methods/standards
MH  - Information Storage and Retrieval/*methods
MH  - *PubMed
MH  - *Review Literature as Topic
MH  - Search Engine/*methods
PMC - PMC3104815
EDAT- 2010/06/17 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/06/17 06:00
PHST- 2010/06/17 06:00 [entrez]
PHST- 2010/06/17 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - la.2010.009117 [pii]
AID - 10.1258/la.2010.009117 [doi]
PST - ppublish
SO  - Lab Anim. 2010 Jul;44(3):170-5. doi: 10.1258/la.2010.009117. Epub 2010 Jun 15.


PMID- 20551183
OWN - NLM
STAT- MEDLINE
DCOM- 20100924
LR  - 20220316
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 256
IP  - 2
DP  - 2010 Aug
TI  - Metastatic renal carcinoma: evaluation of antiangiogenic therapy with dynamic
      contrast-enhanced CT.
PG  - 511-8
LID - 10.1148/radiol.10091362 [doi]
AB  - PURPOSE: To determine whether tumor perfusion parameters assessed by using
      dynamic contrast material-enhanced computed tomography (CT) could help predict
      and detect response in patients receiving antiangiogenic therapy for metastatic
      renal cell carcinoma. MATERIALS AND METHODS: Institutional ethics committee
      approval and informed consent were obtained. In two phase-III trials involving 51
      patients with metastatic renal cell carcinoma (38 men, 13 women; age range, 30-80
      years) receiving antiangiogenic drugs (sorafenib [n = 10], sunitinib [n = 22]), a
      placebo (n = 12), or interferon alfa (n = 7), serial dynamic contrast-enhanced CT
      was performed, during 90 seconds before and after injection of 80 mL of
      iobitridol. Perfusion parameters of a target metastatic tumor (tumor blood flow
      [TBF], tumor blood volume [TBV], mean transit time, and vascular
      permeability-surface area product) were calculated. Values before and after
      treatment were compared by using a Wilcoxon signed rank test, and relative
      changes in groups were compared by using the Wilcoxon rank sum test. Results were
      compared with Response Evaluation Criteria in Solid Tumors response and with
      progression-free and overall survival by using Kaplan-Meier curves. RESULTS:
      Among patients receiving antiangiogenic drugs, baseline perfusion parameters were
      higher in responders than in stable patients (TBF = 245.3 vs 119.5 mL/min/100 mL,
      P = .04; TBV = 15.5 vs 8.2 mL/100 mL, P = .02) but were not significantly
      predictive of survival. After the first cycle of treatment, there was a
      significant decrease in TBF (162.5 vs 76.7 mL/min/100 mL, P = .0002) and TBV (9.1
      vs 3.9 mL/100 mL, P < .0001) in patients receiving antiangiogenic treatment.
      CONCLUSION: Renal carcinoma perfusion parameters determined with dynamic
      contrast-enhanced CT can help predict biologic response to antiangiogenic drugs
      before beginning therapy and help detect an effect after a single cycle of
      treatment.
FAU - Fournier, Laure S
AU  - Fournier LS
AD  - Department of Radiology, Assistance Publique-Hopitaux de Paris, Hopital Europeen 
      Georges Pompidou, 20 rue Leblanc, Paris 75015, France. laure.fournier@egp.aphp
      .fr
FAU - Oudard, Stephane
AU  - Oudard S
FAU - Thiam, Rokhaya
AU  - Thiam R
FAU - Trinquart, Ludovic
AU  - Trinquart L
FAU - Banu, Eugeniu
AU  - Banu E
FAU - Medioni, Jacques
AU  - Medioni J
FAU - Balvay, Daniel
AU  - Balvay D
FAU - Chatellier, Gilles
AU  - Chatellier G
FAU - Frija, Guy
AU  - Frija G
FAU - Cuenod, Charles A
AU  - Cuenod CA
LA  - eng
PT  - Clinical Trial, Phase III
PT  - Controlled Clinical Trial
PT  - Journal Article
DEP - 20100615
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Angiogenesis Inhibitors)
RN  - 0 (Benzenesulfonates)
RN  - 0 (Indoles)
RN  - 0 (Phenylurea Compounds)
RN  - 0 (Pyridines)
RN  - 0 (Pyrroles)
RN  - 25X51I8RD4 (Niacinamide)
RN  - 9ZOQ3TZI87 (Sorafenib)
RN  - V99T50803M (Sunitinib)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Angiogenesis Inhibitors/*administration & dosage
MH  - Benzenesulfonates/*administration & dosage
MH  - *Carcinoma, Renal Cell/diagnostic imaging/drug therapy/secondary
MH  - Female
MH  - Humans
MH  - Indoles/*administration & dosage
MH  - *Kidney Neoplasms/diagnostic imaging/drug therapy/secondary
MH  - Male
MH  - Middle Aged
MH  - Niacinamide/analogs & derivatives
MH  - Phenylurea Compounds
MH  - Prognosis
MH  - Pyridines/*administration & dosage
MH  - Pyrroles/*administration & dosage
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Sorafenib
MH  - Sunitinib
MH  - Tomography, X-Ray Computed/*methods
MH  - Treatment Outcome
EDAT- 2010/06/17 06:00
MHDA- 2010/09/25 06:00
CRDT- 2010/06/17 06:00
PHST- 2010/06/17 06:00 [entrez]
PHST- 2010/06/17 06:00 [pubmed]
PHST- 2010/09/25 06:00 [medline]
AID - radiol.10091362 [pii]
AID - 10.1148/radiol.10091362 [doi]
PST - ppublish
SO  - Radiology. 2010 Aug;256(2):511-8. doi: 10.1148/radiol.10091362. Epub 2010 Jun 15.


PMID- 20551138
OWN - NLM
STAT- MEDLINE
DCOM- 20110509
LR  - 20211020
IS  - 1460-2237 (Electronic)
IS  - 0268-1080 (Linking)
VI  - 26
IP  - 1
DP  - 2011 Jan
TI  - Allocating funds for HIV/AIDS: a descriptive study of KwaDukuza, South Africa.
PG  - 33-42
LID - 10.1093/heapol/czq022 [doi]
AB  - OBJECTIVE: through a descriptive study, we determined the factors that influence 
      the decision-making process for allocating funds to HIV/AIDS prevention and
      treatment programmes, and the extent to which formal decision tools are used in
      the municipality of KwaDukuza, South Africa. METHODS: we conducted 35 key
      informant interviews in KwaDukuza. The interview questions addressed specific
      resource allocation issues while allowing respondents to speak openly about the
      complexities of the HIV/AIDS resource allocation process. RESULTS: donors have a 
      large influence on the decision-making process for HIV/AIDS resource allocation. 
      However, advocacy groups, governmental bodies and local communities also play an 
      important role. Political power, culture and ethics are among a set of intangible
      factors that have a strong influence on HIV/AIDS resource allocation. Formal
      methods, including needs assessment, best practice approaches, epidemiologic
      modelling and cost-effectiveness analysis are sometimes used to support the
      HIV/AIDS resource allocation process. Historical spending patterns are an
      important consideration in future HIV/AIDS allocation strategies. CONCLUSIONS:
      several factors and groups influence resource allocation in KwaDukuza. Although
      formal economic and epidemiologic information is sometimes used, in most cases
      other factors are more important for resource allocation decision-making. These
      other factors should be considered in any attempts to improve the resource
      allocation processes.
FAU - Lasry, Arielle
AU  - Lasry A
AD  - Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, 1600
      Clifton Rd, MS-E-48, Atlanta, GA 30329, USA. alasry@cdc.gov
FAU - Carter, Michael W
AU  - Carter MW
FAU - Zaric, Gregory S
AU  - Zaric GS
LA  - eng
GR  - R01 DA015612/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100615
PL  - England
TA  - Health Policy Plan
JT  - Health policy and planning
JID - 8610614
MH  - Decision Making
MH  - Female
MH  - HIV Infections/economics/*prevention & control
MH  - Health Promotion/*economics
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Resource Allocation/*organization & administration
MH  - South Africa
PMC - PMC3119385
EDAT- 2010/06/17 06:00
MHDA- 2011/05/10 06:00
CRDT- 2010/06/17 06:00
PHST- 2010/06/17 06:00 [entrez]
PHST- 2010/06/17 06:00 [pubmed]
PHST- 2011/05/10 06:00 [medline]
AID - czq022 [pii]
AID - 10.1093/heapol/czq022 [doi]
PST - ppublish
SO  - Health Policy Plan. 2011 Jan;26(1):33-42. doi: 10.1093/heapol/czq022. Epub 2010
      Jun 15.


PMID- 20550743
OWN - NLM
STAT- MEDLINE
DCOM- 20101104
LR  - 20101012
IS  - 1475-2662 (Electronic)
IS  - 0007-1145 (Linking)
VI  - 104
IP  - 8
DP  - 2010 Oct
TI  - Canadian health care professionals' knowledge, attitudes and perceptions of
      nutritional genomics.
PG  - 1112-9
LID - 10.1017/S0007114510002035 [doi]
AB  - Nutritional genomics has reached the public through applications of the Human
      Genome Project offered direct to consumers (DTC). The ability to pursue
      nutrigenetic testing without the involvement of a health care professional has
      received considerable attention from academic and policy commentators. To better 
      understand the knowledge and attitudes of Canadian health care professionals
      regarding nutritional genomics and nutrigenetic testing, qualitative research in 
      the form of focus group discussions was undertaken. Four key themes emerged: (1) 
      concerns over DTC testing; (2) lack of health care professional competency; (3)
      genetic scepticism and inevitability; (4) expectation of regulation. Together,
      they indicate that health care professionals have little knowledge about
      nutritional genomics and hold contradictory attitudes towards genomics in
      general, and to nutritional genomics in particular. Respondents argue in favour
      of a delivery model where health care professionals act as intermediaries. They
      are also aware of their lack of competency to provide such services. To ensure
      greater public protection, respondents cite the importance of more stringent
      regulatory oversight of DTC genetic testing. Whether such an approach is
      necessary to address the various ethical and social issues raised by nutrigenetic
      testing remains an open debate.
FAU - Weir, Mark
AU  - Weir M
AD  - Department of Philosophy, University of Ottawa, Ottawa, ON, Canada.
FAU - Morin, Karine
AU  - Morin K
FAU - Ries, Nola
AU  - Ries N
FAU - Castle, David
AU  - Castle D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100616
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
SB  - IM
MH  - Attitude of Health Personnel
MH  - Canada
MH  - Data Collection
MH  - Focus Groups
MH  - *Health Knowledge, Attitudes, Practice
MH  - *Health Personnel
MH  - Humans
MH  - *Nutrigenomics
MH  - Nutritional Physiological Phenomena/*genetics
EDAT- 2010/06/17 06:00
MHDA- 2010/11/05 06:00
CRDT- 2010/06/17 06:00
PHST- 2010/06/17 06:00 [entrez]
PHST- 2010/06/17 06:00 [pubmed]
PHST- 2010/11/05 06:00 [medline]
AID - S0007114510002035 [pii]
AID - 10.1017/S0007114510002035 [doi]
PST - ppublish
SO  - Br J Nutr. 2010 Oct;104(8):1112-9. doi: 10.1017/S0007114510002035. Epub 2010 Jun 
      16.


PMID- 20550680
OWN - NLM
STAT- MEDLINE
DCOM- 20100924
LR  - 20211020
IS  - 1471-2334 (Electronic)
IS  - 1471-2334 (Linking)
VI  - 10
DP  - 2010 Jun 15
TI  - Is aging raw cattle urine efficient for sampling Anopheles arabiensis Patton?
PG  - 172
LID - 10.1186/1471-2334-10-172 [doi]
AB  - BACKGROUND: To ensure sustainable routine surveillance of mosquito vectors,
      simple, effective and ethically acceptable tools are required. As a part of that,
      we evaluated the efficiency of resting boxes baited with fresh and aging cattle
      urine for indoor and outdoor sampling of An. arabiensis in the lower Moshi rice
      irrigation schemes. METHODS: A cattle urine treatment and re-treatment schedule
      was used, including a box with a piece of cloth re-treated with urine daily, and 
      once after 3 and 7 day. Resting box with piece of black cloth not treated with
      urine was used as a control. Each treatment was made in pair for indoor and
      outdoor sampling. A 4 by 4 Latin square design was used to achieve equal rotation
      of each of the four treatments across the experimental houses. Sampling was done 
      over a period of 6 months, once per week. RESULTS: A total of 7871 mosquitoes
      were collected throughout the study period. 49.8% of the mosquitoes were
      collected from resting box treated with urine daily; 21.6% and 20.0% were from
      boxes treated 3 and 7 days respectively. Only 8.6% were from untreated resting
      box (control). The proportion collected indoors was approximately 2 folds greater
      than the outdoor. Of all mosquitoes, 12.3% were unfed, 4.1% full fed, 34.2%
      semi-gravid and 49.4% gravid. CONCLUSION: Fresh and decaying cattle urine odour
      baited resting boxes offer an alternative tool for sampling particularly
      semi-gravid and gravid An. arabiensis. Evaluation in low density seasons of An.
      arabiensis in different ecological settings remains necessary. This sampling
      method may be standardized for replacing human landing catch.
FAU - Mahande, Aneth M
AU  - Mahande AM
AD  - Tropical Pesticides Research Institute, Division of Livestock and Human Disease
      vector control, Mosquito Section, P,O, Box 3024, Arusha, Tanzania.
FAU - Mwang'onde, Beda J
AU  - Mwang'onde BJ
FAU - Msangi, Shandala
AU  - Msangi S
FAU - Kimaro, Epiphania
AU  - Kimaro E
FAU - Mnyone, Ladslaus L
AU  - Mnyone LL
FAU - Mazigo, Humphrey D
AU  - Mazigo HD
FAU - Mahande, Michael J
AU  - Mahande MJ
FAU - Kweka, Eliningaya J
AU  - Kweka EJ
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100615
PL  - England
TA  - BMC Infect Dis
JT  - BMC infectious diseases
JID - 100968551
RN  - 0 (Pheromones)
RN  - 0 (insect attractants)
SB  - IM
MH  - Animals
MH  - *Anopheles
MH  - Cattle
MH  - Mosquito Control/*methods
MH  - Parasitology/*methods
MH  - Pheromones/*pharmacology
MH  - Time Factors
MH  - Urine/*parasitology
PMC - PMC2896370
EDAT- 2010/06/17 06:00
MHDA- 2010/09/25 06:00
CRDT- 2010/06/17 06:00
PHST- 2009/10/17 00:00 [received]
PHST- 2010/06/15 00:00 [accepted]
PHST- 2010/06/17 06:00 [entrez]
PHST- 2010/06/17 06:00 [pubmed]
PHST- 2010/09/25 06:00 [medline]
AID - 1471-2334-10-172 [pii]
AID - 10.1186/1471-2334-10-172 [doi]
PST - epublish
SO  - BMC Infect Dis. 2010 Jun 15;10:172. doi: 10.1186/1471-2334-10-172.


PMID- 20550639
OWN - NLM
STAT- MEDLINE
DCOM- 20101008
LR  - 20191210
IS  - 1447-0349 (Electronic)
IS  - 1445-8330 (Linking)
VI  - 19
IP  - 3
DP  - 2010 Jun
TI  - Nurses' attitudes to the use of seclusion: a review of the literature.
PG  - 162-8
LID - 10.1111/j.1447-0349.2010.00669.x [doi]
AB  - Seclusion is now widely recognized as a coercive strategy with negative
      consequences for the consumers and staff involved. Nevertheless, this
      intervention continues to be used frequently in mental health services
      internationally. Due to their direct care role, nurses are commonly involved in
      the initiation or management of seclusion. Understanding nurses' attitudes to
      seclusion is therefore essential for the success of any attempts to reduce its
      use. A review of the literature was conducted using the search terms 'patient',
      'seclusion', 'attitudes', 'nurses' and 'containment'. Twenty-eight articles which
      met the inclusion criteria were identified. Analysis of these articles identified
      six main themes: a necessary intervention; workplace culture; staff composition
      and experience; conflict; ethical considerations; and consumer characteristics.
      An overview of the literature is presented according to these main themes. The
      research suggests that most nurses support the continued use of seclusion as a
      strategy for the management of violence and aggression. A deeper understanding of
      the factors that influence attitudes is necessary if seclusion rates are to be
      effectively reduced.
FAU - Happell, Brenda
AU  - Happell B
AD  - Department of Health Innovation and Institute for Health and Social Science
      Research, CQ University Australia, Rockhampton, Queensland, Australia.
      b.happell@cqu.edu.au
FAU - Harrow, Alison
AU  - Harrow A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Australia
TA  - Int J Ment Health Nurs
JT  - International journal of mental health nursing
JID - 101140527
CIN - Int J Ment Health Nurs. 2010 Jun;19(3):151-3. PMID: 20550637
MH  - *Attitude of Health Personnel
MH  - Conflict, Psychological
MH  - Humans
MH  - Mental Disorders/nursing/psychology
MH  - Nurse-Patient Relations
MH  - Nursing Methodology Research
MH  - Organizational Culture
MH  - Patient Isolation/ethics/*organization & administration/psychology
MH  - Patient Selection
MH  - Personnel Staffing and Scheduling
MH  - Psychiatric Nursing/ethics/*organization & administration
MH  - Restraint, Physical
MH  - Violence/prevention & control/psychology
MH  - Workplace/organization & administration/psychology
RF  - 51
EDAT- 2010/06/17 06:00
MHDA- 2010/10/12 06:00
CRDT- 2010/06/17 06:00
PHST- 2010/06/17 06:00 [entrez]
PHST- 2010/06/17 06:00 [pubmed]
PHST- 2010/10/12 06:00 [medline]
AID - INM669 [pii]
AID - 10.1111/j.1447-0349.2010.00669.x [doi]
PST - ppublish
SO  - Int J Ment Health Nurs. 2010 Jun;19(3):162-8. doi:
      10.1111/j.1447-0349.2010.00669.x.


PMID- 20550092
OWN - NLM
STAT- MEDLINE
DCOM- 20100708
LR  - 20191111
IS  - 0745-5194 (Print)
IS  - 0745-5194 (Linking)
VI  - 24
IP  - 2
DP  - 2010 Jun
TI  - "I never wanted to be a quack!" The professional deviance of plaintiff experts in
      contested illness lawsuits: the case of multiple chemical sensitivities.
PG  - 182-98
AB  - When medical practitioners act as expert witnesses for the plaintiff in contested
      illness lawsuits, they can be stigmatized by their professional community.
      Drawing on ethnographic research surrounding the condition multiple chemical
      sensitivities (MCS) in Australia, this article focuses on: how plaintiff experts 
      specialize; their rationale for deviance from the professional norm; and
      structural constraints to medical advocacy. By diagnosing and treating the
      condition as organic, these experts oppose the accepted disease paradigm of the
      medical community and therefore face professional isolation and peer pressure.
      They rationalize their continued advocacy within a moral discourse, which
      includes a professional aspiration toward altruism, an ethical commitment to
      "truth," and the explicit emphasis that financial gain is not a motivation. For
      their deviance the experts have been confronted with professional disillusionment
      and emotional drain. Ultimately, the medical profession is disenfranchising
      experts who may be vital characters in the quest for understanding about
      environmental illnesses.
FAU - Phillips, Tarryn
AU  - Phillips T
AD  - Anthropology and Sociology, University of Western Australia.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Anthropol Q
JT  - Medical anthropology quarterly
JID - 8405037
SB  - IM
MH  - Attitude of Health Personnel
MH  - Australia
MH  - Decision Making
MH  - *Expert Testimony
MH  - Humans
MH  - Multiple Chemical Sensitivity/*diagnosis
MH  - *Physicians
EDAT- 2010/06/17 06:00
MHDA- 2010/07/09 06:00
CRDT- 2010/06/17 06:00
PHST- 2010/06/17 06:00 [entrez]
PHST- 2010/06/17 06:00 [pubmed]
PHST- 2010/07/09 06:00 [medline]
AID - 10.1111/j.1548-1387.2010.01096.x [doi]
PST - ppublish
SO  - Med Anthropol Q. 2010 Jun;24(2):182-98. doi: 10.1111/j.1548-1387.2010.01096.x.


PMID- 20549598
OWN - NLM
STAT- MEDLINE
DCOM- 20120117
LR  - 20110622
IS  - 1439-4421 (Electronic)
IS  - 0941-3790 (Linking)
VI  - 73
IP  - 6
DP  - 2011 Jun
TI  - [Guidance of medical experts].
PG  - 350-6
LID - 10.1055/s-0030-1254169 [doi]
AB  - Guidance is an issue of growing importance for physicians responsible for medical
      experts working in public health services and on medical advisory boards. The
      challenge of ethics on the one hand and the constraints of economy on the other
      hand have considerable impact on the demands for quantity as well as quality of
      the expert opinions. Thus, executive staff in these organisations reflect as to
      whether and how they can influence performance through guidance. A short summary 
      of the results of research on the subject of guidance - concerning the aspects
      (i) guidance as an interaction of people, (ii) guidance as a task in a concrete
      situation and (iii) guidance as a systemic process of development - shows and
      points out a wide range of possibilities for staff management and personnel
      development of medical consultants. Guidance of medical experts is possible and
      necessary in order to develop the professionalism of medical experts, in order to
      ensure quality, conformity to standards and efficiency of medical expertise, as
      well as for a future-oriented development of the medical advisory boards
      themselves.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Nuchtern, E
AU  - Nuchtern E
AD  - Medizinischer Dienst der Krankenversicherung (MDK) Baden-Wurttemberg.
FAU - Mohrmann, M
AU  - Mohrmann M
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Fuhrung arztlicher Gutachter.
DEP - 20100614
PL  - Germany
TA  - Gesundheitswesen
JT  - Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes
      (Germany))
JID - 9204210
SB  - IM
MH  - Clinical Competence/standards
MH  - Ethics, Medical
MH  - Expert Testimony/ethics/*standards
MH  - Germany
MH  - Guideline Adherence/standards
MH  - Humans
MH  - Quality Assurance, Health Care/ethics/*standards
MH  - Staff Development/ethics/standards
EDAT- 2010/06/16 06:00
MHDA- 2012/01/18 06:00
CRDT- 2010/06/16 06:00
PHST- 2010/06/16 06:00 [entrez]
PHST- 2010/06/16 06:00 [pubmed]
PHST- 2012/01/18 06:00 [medline]
AID - 10.1055/s-0030-1254169 [doi]
PST - ppublish
SO  - Gesundheitswesen. 2011 Jun;73(6):350-6. doi: 10.1055/s-0030-1254169. Epub 2010
      Jun 14.


PMID- 20549526
OWN - NLM
STAT- MEDLINE
DCOM- 20101130
LR  - 20211020
IS  - 1435-165X (Electronic)
IS  - 1018-8827 (Linking)
VI  - 19
IP  - 9
DP  - 2010 Sep
TI  - Eunethydis: a statement of the ethical principles governing the relationship
      between the European group for ADHD guidelines, and its members, with commercial 
      for-profit organisations.
PG  - 737-9
LID - 10.1007/s00787-010-0114-8 [doi]
AB  - The Eunethydis ADHD Guidelines group set out here the ethical principles
      governing the relationship between the group and industry. The principles set out
      here are provided to ensure that this is both done and seen to be done. The
      impetus for these guidelines comes from within the Group and is linked to the
      recognition for the need for an open and transparent basis for Group-industry
      relations, especially in the light of the present concern that the pharmaceutical
      industry may be exerting a growing influence on the actions of researchers and
      clinicians in the ADHD field.
FAU - Sergeant, Joseph A
AU  - Sergeant JA
AD  - Clinical Neuropsychology, Vrije Universiteit, Amsterdam, The Netherlands.
      JA.Sergeant@psy.vu.nl
FAU - Banaschewski, Tobias
AU  - Banaschewski T
FAU - Buitelaar, Jan
AU  - Buitelaar J
FAU - Coghill, David
AU  - Coghill D
FAU - Danckaerts, Marina
AU  - Danckaerts M
FAU - Dopfner, Manfred
AU  - Dopfner M
FAU - Rothenberger, A
AU  - Rothenberger A
FAU - Santosh, Paramala
AU  - Santosh P
FAU - Sonuga-Barke, E J S
AU  - Sonuga-Barke EJ
FAU - Steinhausen, Hans-Christoph
AU  - Steinhausen HC
FAU - Taylor, Eric
AU  - Taylor E
FAU - Zuddas, A
AU  - Zuddas A
LA  - eng
PT  - Journal Article
DEP - 20100612
PL  - Germany
TA  - Eur Child Adolesc Psychiatry
JT  - European child & adolescent psychiatry
JID - 9212296
SB  - IM
EIN - Eur Child Adolesc Psychiatry. 2010 Sep;19(9):743. Buitelar, Jan [corrected to
      Buitelaar, Jan]
MH  - *Attention Deficit Disorder with Hyperactivity
MH  - *Conflict of Interest
MH  - Drug Industry/*ethics
MH  - Guidelines as Topic
MH  - Humans
PMC - PMC3128714
EDAT- 2010/06/16 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/06/16 06:00
PHST- 2009/11/18 00:00 [received]
PHST- 2010/05/19 00:00 [accepted]
PHST- 2010/06/16 06:00 [entrez]
PHST- 2010/06/16 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1007/s00787-010-0114-8 [doi]
PST - ppublish
SO  - Eur Child Adolesc Psychiatry. 2010 Sep;19(9):737-9. doi:
      10.1007/s00787-010-0114-8. Epub 2010 Jun 12.


PMID- 20549468
OWN - NLM
STAT- MEDLINE
DCOM- 20140522
LR  - 20101015
IS  - 0724-6145 (Print)
IS  - 0724-6145 (Linking)
VI  - 123
DP  - 2010
TI  - Induced pluripotent stem cell technology in regenerative medicine and biology.
PG  - 127-41
LID - 10.1007/10_2010_72 [doi]
AB  - The potential of human embryonic stem cells (ESCs) for regenerative medicine is
      unquestionable, but practical and ethical considerations have hampered clinical
      application and research. In an attempt to overcome these issues, the conversion 
      of somatic cells into pluripotent stem cells similar to ESCs, commonly termed
      nuclear reprogramming, has been a top objective of contemporary biology. More
      than 40 years ago, King, Briggs, and Gurdon pioneered somatic cell nuclear
      reprogramming in frogs, and in 1981 Evans successfully isolated mouse ESCs. In
      1997 Wilmut and collaborators produced the first cloned mammal using nuclear
      transfer, and then Thomson obtained human ESCs from in vitro fertilized
      blastocysts in 1998. Over the last 2 decades we have also seen remarkable
      findings regarding how ESC behavior is controlled, the importance of which should
      not be underestimated. This knowledge allowed the laboratory of Shinya Yamanaka
      to overcome brilliantly conceptual and technical barriers in 2006 and generate
      induced pluripotent stem cells (iPSCs) from mouse fibroblasts by overexpressing
      defined combinations of ESC-enriched transcription factors. Here, we discuss some
      important implications of human iPSCs for biology and medicine and also point to 
      possible future directions.
FAU - Pei, Duanqing
AU  - Pei D
AD  - Stem Cell and Cancer Biology Group, Key Laboratory of Regenerative Biology, South
      China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou
      Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou,
      510530, China, pei_duanqing@gibh.ac.cn.
FAU - Xu, Jianyong
AU  - Xu J
FAU - Zhuang, Qiang
AU  - Zhuang Q
FAU - Tse, Hung-Fat
AU  - Tse HF
FAU - Esteban, Miguel A
AU  - Esteban MA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Adv Biochem Eng Biotechnol
JT  - Advances in biochemical engineering/biotechnology
JID - 8307733
SB  - IM
MH  - Animals
MH  - Cell Culture Techniques/*methods
MH  - Cell Differentiation/physiology
MH  - Cell Proliferation
MH  - Cell Separation/*methods
MH  - Cells, Cultured
MH  - Guided Tissue Regeneration/*methods
MH  - Humans
MH  - Pluripotent Stem Cells/*cytology/*physiology
MH  - Regeneration/*physiology
MH  - Tissue Engineering/*methods
EDAT- 2010/06/16 06:00
MHDA- 2014/05/23 06:00
CRDT- 2010/06/16 06:00
PHST- 2010/06/16 06:00 [entrez]
PHST- 2010/06/16 06:00 [pubmed]
PHST- 2014/05/23 06:00 [medline]
AID - 10.1007/10_2010_72 [doi]
PST - ppublish
SO  - Adv Biochem Eng Biotechnol. 2010;123:127-41. doi: 10.1007/10_2010_72.


PMID- 20549464
OWN - NLM
STAT- MEDLINE
DCOM- 20100927
LR  - 20211020
IS  - 1863-6713 (Electronic)
IS  - 1863-6705 (Linking)
VI  - 58
IP  - 6
DP  - 2010 Jun
TI  - Preventing a pitfall: no-knife staplers that require caution during handling.
PG  - 306-7
LID - 10.1007/s11748-009-0560-8 [doi]
AB  - For safer division of the pulmonary vessels at video-assisted thoracoscopic
      surgery (VATS), a no-knife stapler (NAW ENDOPATH Flex45 No Knife Endoscopic
      Linear Stapler, Ethicon Endo-Surgery) is of help. We have used it during 177
      sessions in 156 patients and noted two incidences where several of the staples
      were malformed but did not cause a bleeding event. A close investigation revealed
      that the cause was excessive rotation of the articulation lever. Thus, to avoid
      staple malformation, the articulation lever should not be rotated beyond its
      limit of mobility.
FAU - Yoshida, Junichi
AU  - Yoshida J
AD  - Shimonoseki City Central Hospital, Shimonoseki, Japan. yoshidaj@uicalumni.org
FAU - Furugaki, Koichi
AU  - Furugaki K
LA  - eng
PT  - Journal Article
DEP - 20100613
PL  - Japan
TA  - Gen Thorac Cardiovasc Surg
JT  - General thoracic and cardiovascular surgery
JID - 101303952
SB  - IM
MH  - Equipment Design
MH  - Humans
MH  - Postoperative Complications/*prevention & control
MH  - Pulmonary Artery/*surgery
MH  - Pulmonary Veins/*surgery
MH  - Rotation
MH  - *Surgical Staplers
MH  - Surgical Stapling/adverse effects/*instrumentation
MH  - Thoracic Surgery, Video-Assisted/adverse effects/*instrumentation
MH  - Treatment Outcome
EDAT- 2010/06/16 06:00
MHDA- 2010/09/29 06:00
CRDT- 2010/06/16 06:00
PHST- 2009/07/21 00:00 [received]
PHST- 2009/11/02 00:00 [accepted]
PHST- 2010/06/16 06:00 [entrez]
PHST- 2010/06/16 06:00 [pubmed]
PHST- 2010/09/29 06:00 [medline]
AID - 10.1007/s11748-009-0560-8 [doi]
PST - ppublish
SO  - Gen Thorac Cardiovasc Surg. 2010 Jun;58(6):306-7. doi: 10.1007/s11748-009-0560-8.
      Epub 2010 Jun 13.


PMID- 20549212
OWN - NLM
STAT- MEDLINE
DCOM- 20101122
LR  - 20211020
IS  - 1432-1963 (Electronic)
IS  - 0172-8113 (Linking)
VI  - 31
IP  - 4
DP  - 2010 Jul
TI  - [Clinical autopsies. Practical approach, legal foundations and ethical
      considerations].
PG  - 256-67
LID - 10.1007/s00292-010-1286-1 [doi]
AB  - Only an autopsy can demonstrate topographical and morphological circumstances in 
      detail and correlate the clinical and autopsy findings based on the examination
      of all organs. The practical approach in a fatality is described based on the
      example of the Ludenscheid Hospital. A uniform legal regulation for dealing with 
      corpses does not exist in Germany. There are two approaches to the question under
      which circumstances a clinical autopsy is allowed: the extended permission
      solution and the objection solution. Whether a clinical autopsy can be carried
      out is decided by the medical specialist selected on application. Autopsies can
      be necessary from insurance or administrative legal grounds or in the case of an 
      anatomical autopsy is decided by the persons themselves. In order to guarantee
      the quality of an autopsy it is necessary to use a standardized approach with
      evaluation and assessment of the results, for example using a quality assurance
      protocol and the production of an autopsy report. Using this approach important
      information can be gained not only on the accuracy of the main diagnosis and
      cause of death but also on additional diseases, response to therapy and the
      course of the disease and under circumstances can lead to modifications in the
      approach.
FAU - Friemann, J
AU  - Friemann J
AD  - Institut fur Pathologie, Markische Kliniken GmbH, Paulmannshoher Str. 14, 58515, 
      Ludenscheid, Deutschland. Johannes.Friemann@klinikum-luedenscheid.de
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Klinische Obduktionen. Praktisches Vorgehen, rechtliche Grundlagen und ethische
      Uberlegungen.
PL  - Germany
TA  - Pathologe
JT  - Der Pathologe
JID - 8006541
SB  - IM
MH  - Accidents, Occupational/legislation & jurisprudence
MH  - Advance Directives/ethics/legislation & jurisprudence
MH  - Autopsy/*ethics/*legislation & jurisprudence/standards
MH  - Death Certificates/legislation & jurisprudence
MH  - Death, Sudden/pathology
MH  - Documentation/ethics/standards
MH  - *Ethics, Medical
MH  - Expert Testimony/ethics/legislation & jurisprudence
MH  - Female
MH  - Fetal Death/pathology
MH  - Germany
MH  - Humans
MH  - Infant, Newborn
MH  - Insurance, Accident/ethics/legislation & jurisprudence
MH  - Insurance, Life/ethics/legislation & jurisprudence
MH  - Legal Guardians/legislation & jurisprudence
MH  - Medical Errors/ethics/legislation & jurisprudence
MH  - Pregnancy
MH  - Quality Assurance, Health Care/*ethics/*legislation & jurisprudence
MH  - Suicide/ethics/legislation & jurisprudence
MH  - Wounds and Injuries/pathology
EDAT- 2010/06/16 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/06/16 06:00
PHST- 2010/06/16 06:00 [entrez]
PHST- 2010/06/16 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1007/s00292-010-1286-1 [doi]
PST - ppublish
SO  - Pathologe. 2010 Jul;31(4):256-67. doi: 10.1007/s00292-010-1286-1.


PMID- 20549038
OWN - NLM
STAT- MEDLINE
DCOM- 20101207
LR  - 20190923
IS  - 1678-2925 (Electronic)
IS  - 0004-2749 (Linking)
VI  - 73
IP  - 2
DP  - 2010 Mar-Apr
TI  - Temporary management of involutional entropion with octyl-2-cyanoacrylate liquid 
      bandage application.
PG  - 120-4
LID - S0004-27492010000200004 [pii]
AB  - PURPOSE: To evaluate the use of octyl-2-cyanoacrylate liquid bandage (Band-Aid
      liquid, Ethicon, Johnson & Johnson, New Jersey, USA) as a temporary treatment in 
      patients awaiting surgical repair for involutional entropion. METHODS: Thirteen
      patients (15 eyelids) with involutional entropion were evaluated while they
      waited for surgical intervention. The lids were repositioned by the application
      of octyl-2-cyanoacrylate liquid bandage in the malar fold. Patients were
      followed-up at days 1, 7 and 15. Assessment and duration of correction were
      recorded. RESULTS: All the patients presented successful correction at day 1,
      with significant improvements in signs and symptoms. The mean duration of action 
      of the octyl2-cyanoacrylate liquid bandage was three days. No ocular or
      dermatological reactions were noted. CONCLUSION: Octyl-2-cyanoacrylate liquid
      bandage showed to be a simple, safe and effective option to temporarily treat
      involutional entropion, while patients waited for surgical intervention.
FAU - Osaki, Teissy
AU  - Osaki T
AD  - Vision Institute, UNIFESP, Sao Paulo, SP, Brazil. teissyosaki@yahoo.com.br
FAU - Osaki, Midori Hentona
AU  - Osaki MH
FAU - Osaki, Tammy Hentona
AU  - Osaki TH
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - Arq Bras Oftalmol
JT  - Arquivos brasileiros de oftalmologia
JID - 0400645
RN  - 0 (Cyanoacrylates)
RN  - 0 (Tissue Adhesives)
RN  - 6C655P1XVG (octyl 2-cyanoacrylate)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cyanoacrylates/*therapeutic use
MH  - Entropion/*therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Tissue Adhesives/*therapeutic use
MH  - Treatment Outcome
EDAT- 2010/06/16 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/06/16 06:00
PHST- 2009/09/08 00:00 [received]
PHST- 2010/03/15 00:00 [accepted]
PHST- 2010/06/16 06:00 [entrez]
PHST- 2010/06/16 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S0004-27492010000200004 [pii]
AID - 10.1590/s0004-27492010000200004 [doi]
PST - ppublish
SO  - Arq Bras Oftalmol. 2010 Mar-Apr;73(2):120-4. doi:
      10.1590/s0004-27492010000200004.


PMID- 20548045
OWN - NLM
STAT- MEDLINE
DCOM- 20100719
LR  - 20220311
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Linking)
VI  - 74
IP  - 24
DP  - 2010 Jun 15
TI  - New perspectives in the natural history of multiple sclerosis.
PG  - 2004-15
LID - 10.1212/WNL.0b013e3181e3973f [doi]
AB  - Multiple sclerosis (MS) has entered an era of immunomodulatory drug treatment,
      the impact of which on long-term disease progression remains controversial. The
      increasing use of these therapies has intensified our need to understand the true
      natural history of MS. The MS community is poised to establish whether the
      immunomodulatory drugs exhibit long-term benefits, with a suitable untreated
      natural history cohort likely the most practical and ethical comparator group.
      Thus, a thorough understanding of the natural history of MS is fundamental. In
      this review, we highlight recent advances in MS natural history over the last 5
      years, with a focus on long-term population-based cohorts and factors associated 
      with disease progression. Survival in MS has increased and longer times to
      irreversible disability have been reported in contemporary studies, indicating a 
      slower accumulation of disability. Wide variation in the MS disease trajectory is
      evident within and between natural history studies, reflecting both methodologic 
      considerations related to data collection and heterogeneity of disease activity. 
      Recent publications have indicated that a younger age at disease onset is no
      longer indicative of a favorable outcome and further evidence supports the
      dissociation between relapses and long-term disability, although windows of
      opportunity may exist for some patients. We are now perhaps faced with our last
      chance to examine the true natural history of MS, so whether the reader is a
      practicing physician, health care provider, or researcher, or engaged in the
      pharmaceutical industry or in clinical trial design, recent advances in our
      understanding of the natural history of MS are of key significance.
FAU - Tremlett, Helen
AU  - Tremlett H
AD  - Faculty of Medicine, Division of Neurology, Multiple Sclerosis Program,
      University of British Columbia, Vancouver, Canada. tremlett@interchange.ubc.ca
FAU - Zhao, Yinshan
AU  - Zhao Y
FAU - Rieckmann, Peter
AU  - Rieckmann P
FAU - Hutchinson, Michael
AU  - Hutchinson M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
SB  - IM
MH  - Clinical Trials as Topic/trends
MH  - Disease Progression
MH  - Humans
MH  - Multiple Sclerosis/diagnosis/*pathology/*therapy
MH  - Risk Factors
MH  - Survival Rate/trends
RF  - 60
EDAT- 2010/06/16 06:00
MHDA- 2010/07/20 06:00
CRDT- 2010/06/16 06:00
PHST- 2010/06/16 06:00 [entrez]
PHST- 2010/06/16 06:00 [pubmed]
PHST- 2010/07/20 06:00 [medline]
AID - 74/24/2004 [pii]
AID - 10.1212/WNL.0b013e3181e3973f [doi]
PST - ppublish
SO  - Neurology. 2010 Jun 15;74(24):2004-15. doi: 10.1212/WNL.0b013e3181e3973f.


PMID- 20547718
OWN - NLM
STAT- MEDLINE
DCOM- 20100922
LR  - 20211020
IS  - 1488-2329 (Electronic)
IS  - 0820-3946 (Linking)
VI  - 182
IP  - 10
DP  - 2010 Jul 13
TI  - Proposed tax credit for organ donation raises ethical concerns.
PG  - E461-2
LID - 10.1503/cmaj.109-3282 [doi]
FAU - Skura, Elyse
AU  - Skura E
LA  - eng
PT  - News
DEP - 20100614
PL  - Canada
TA  - CMAJ
JT  - CMAJ : Canadian Medical Association journal = journal de l'Association medicale
      canadienne
JID - 9711805
SB  - IM
MH  - Canada
MH  - Family
MH  - Humans
MH  - Taxes/*legislation & jurisprudence
MH  - Tissue and Organ Procurement/*ethics/legislation & jurisprudence
PMC - PMC2900363
EDAT- 2010/06/16 06:00
MHDA- 2010/09/24 06:00
CRDT- 2010/06/16 06:00
PHST- 2010/06/16 06:00 [entrez]
PHST- 2010/06/16 06:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
AID - cmaj.109-3282 [pii]
AID - 10.1503/cmaj.109-3282 [doi]
PST - ppublish
SO  - CMAJ. 2010 Jul 13;182(10):E461-2. doi: 10.1503/cmaj.109-3282. Epub 2010 Jun 14.


PMID- 20547687
OWN - NLM
STAT- MEDLINE
DCOM- 20100701
LR  - 20181023
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 340
DP  - 2010 Jun 14
TI  - What attributes should clinical ethics committees have?
PG  - c2946
LID - 10.1136/bmj.c2946 [doi]
LID - bmj.c2946 [pii]
FAU - Gillon, Raanan
AU  - Gillon R
LA  - eng
PT  - Editorial
DEP - 20100614
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
SB  - IM
MH  - Ethics Committees, Clinical/organization & administration/*standards
MH  - Knowledge Bases
EDAT- 2010/06/16 06:00
MHDA- 2010/07/02 06:00
CRDT- 2010/06/16 06:00
PHST- 2010/06/16 06:00 [entrez]
PHST- 2010/06/16 06:00 [pubmed]
PHST- 2010/07/02 06:00 [medline]
AID - 10.1136/bmj.c2946 [doi]
PST - epublish
SO  - BMJ. 2010 Jun 14;340:c2946. doi: 10.1136/bmj.c2946.


PMID- 20547437
OWN - NLM
STAT- MEDLINE
DCOM- 20100831
LR  - 20211020
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 71
IP  - 4
DP  - 2010 Aug
TI  - Specifying the effects of religion on medical helpseeking: the case of
      infertility.
PG  - 734-42
LID - 10.1016/j.socscimed.2010.04.033 [doi]
AB  - Several recent studies have examined the connection between religion and medical 
      service utilization. This relationship is complicated because religiosity may be 
      associated with beliefs that either promote or hinder medical helpseeking. The
      current study uses structural equation modeling to examine the relationship
      between religion and fertility-related helpseeking using a probability sample of 
      2183 infertile women in the United States. We found that, although religiosity is
      not directly associated with helpseeking for infertility, it is indirectly
      associated through mediating variables that operate in opposing directions. More 
      specifically, religiosity is associated with greater belief in the importance of 
      motherhood, which in turn is associated with increased likelihood of helpseeking.
      Religiosity is also associated with greater ethical concerns about infertility
      treatment, which are associated with decreased likelihood of helpseeking.
      Additionally, the relationships are not linear throughout the helpseeking
      process. Thus, the influence of religiosity on infertility helpseeking is
      indirect and complex. These findings support the growing consensus that
      religiously-based behaviours and beliefs are associated with levels of health
      service utilization.
CI  - (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Greil, Arthur
AU  - Greil A
AD  - Alfred University, Division of Social Sciences, Alfred, NY 14802, USA.
      fgreil@alfred.edu
FAU - McQuillan, Julia
AU  - McQuillan J
FAU - Benjamins, Maureen
AU  - Benjamins M
FAU - Johnson, David R
AU  - Johnson DR
FAU - Johnson, Katherine M
AU  - Johnson KM
FAU - Heinz, Chelsea R
AU  - Heinz CR
LA  - eng
GR  - R01 HD044144/HD/NICHD NIH HHS/United States
GR  - R01 HD044144-03/HD/NICHD NIH HHS/United States
GR  - R01-HD044144/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100524
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Infertility, Female/*psychology/therapy
MH  - Interviews as Topic
MH  - Middle Aged
MH  - Models, Theoretical
MH  - Patient Acceptance of Health Care/*psychology/statistics & numerical data
MH  - *Religion and Medicine
MH  - Reproductive Medicine/ethics/statistics & numerical data
MH  - Reproductive Techniques, Assisted/*statistics & numerical data
MH  - Social Values
PMC - PMC2910170
MID - NIHMS214444
EDAT- 2010/06/16 06:00
MHDA- 2010/09/02 06:00
CRDT- 2010/06/16 06:00
PHST- 2009/09/30 00:00 [received]
PHST- 2010/04/13 00:00 [revised]
PHST- 2010/04/30 00:00 [accepted]
PHST- 2010/06/16 06:00 [entrez]
PHST- 2010/06/16 06:00 [pubmed]
PHST- 2010/09/02 06:00 [medline]
AID - S0277-9536(10)00378-3 [pii]
AID - 10.1016/j.socscimed.2010.04.033 [doi]
PST - ppublish
SO  - Soc Sci Med. 2010 Aug;71(4):734-42. doi: 10.1016/j.socscimed.2010.04.033. Epub
      2010 May 24.


PMID- 20547113
OWN - NLM
STAT- MEDLINE
DCOM- 20100929
LR  - 20220331
IS  - 1553-4650 (Print)
IS  - 1553-4650 (Linking)
VI  - 17
IP  - 4
DP  - 2010 Jul-Aug
TI  - One-year outcome of concurrent anterior and posterior transvaginal mesh surgery
      for treatment of advanced urogenital prolapse: case series.
PG  - 473-9
LID - 10.1016/j.jmig.2010.03.003 [doi]
AB  - STUDY OBJECTIVE: To estimate the safety and efficacy of performing concurrent
      anterior and posterior transvaginal mesh surgery using a commercially available
      kit (Gynecare PROLIFT Pelvic Floor Repair System; Ethicon, Inc., Somerville, NJ) 
      for treatment of advanced urogenital prolapse (stage III or higher, Pelvic Organ 
      Prolapse Quantification [POP-Q] system staging). DESIGN: Case control series
      study (Canadian Task Force classification II-2). SETTING: Medical
      school-affiliated hospital. PATIENTS: Forty-three patients with severe prolapse, 
      POP-Q stage III (n=23) or IV (n=20), underwent surgery and were followed up for
      more than 1 year. In patients with any prolapse greater than stage I, surgery
      were considered to have functional failure. The Surgical Satisfaction
      Questionnaire was used for subjective evaluation at 1 year postoperatively.
      INTERVENTIONS: Extensive pelvic reconstructive procedures were primarily
      performed using a combination of the PROLIFT anterior and posterior pelvic
      systems (i.e., similar to sparing the intermediate section of the PROLIFT total
      pelvic system). The concurrent pelvic surgery included sequential vaginal total
      hysterectomy, perineorrhaphy, and suburethra sling, if indicated. Additional
      subjective and objective evaluations included POP-Q staging, urodynamic
      assessment, and preoperative and 12-month postoperative questionnaires.
      MEASUREMENTS AND MAIN RESULTS: Objective and subjective data were available for
      42 patients. The subjective cure rate and objective success rate for prolapse at 
      12-month follow-up was 95.2% and 97.6%, respectively. Mean follow-up was 15.7
      months, operation time was 79.2 minutes, operative blood loss was 109.1 mL, and
      postoperative hospital stay was 4.1 days. Intraoperative and postoperative
      complications were minor. All patients voided spontaneously before discharge. One
      mesh extrusion, no wound defective healing, and no rejection were observed. Two
      patients developed asymptomatic recurrent rectocele (stage II, POP-Q staging)
      that required no surgical intervention. Urodynamic parameters related to voiding 
      dysfunction improved after surgery. Significant improvements were found using the
      Incontinence Impact Questionnaire and the Urogenital Distress Inventory.
      CONCLUSION: Using concurrent anterior and posterior transvaginal mesh for pelvic 
      reconstructive surgery is a safe and an effective method for treating advanced
      pelvic prolapse. Mesh-related complications are likely minimal, and mesh
      protrusion at the apex is likely to not occur. Further studies with longer
      follow-up are required to evaluate long-term effectiveness.
CI  - Copyright (c) 2010 AAGL. Published by Elsevier Inc. All rights reserved.
FAU - Lo, Tsia-Shu
AU  - Lo TS
AD  - Division of Urogynecology, Department of Obstetrics and Gynecology, Chang Gung
      Memorial Hospital, Chang Gung University School of Medicine, Taoyuan, Taiwan.
      2378@cgmh.com.tw
LA  - eng
PT  - Journal Article
DEP - 20100523
PL  - United States
TA  - J Minim Invasive Gynecol
JT  - Journal of minimally invasive gynecology
JID - 101235322
SB  - IM
MH  - Aged
MH  - Case-Control Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hysterectomy, Vaginal
MH  - Middle Aged
MH  - Patient Satisfaction
MH  - Pelvic Organ Prolapse/*surgery
MH  - Severity of Illness Index
MH  - Suburethral Slings
MH  - *Surgical Mesh
MH  - Treatment Outcome
MH  - Urodynamics
EDAT- 2010/06/16 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/06/16 06:00
PHST- 2009/11/16 00:00 [received]
PHST- 2010/02/26 00:00 [revised]
PHST- 2010/03/06 00:00 [accepted]
PHST- 2010/06/16 06:00 [entrez]
PHST- 2010/06/16 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - S1553-4650(10)00115-9 [pii]
AID - 10.1016/j.jmig.2010.03.003 [doi]
PST - ppublish
SO  - J Minim Invasive Gynecol. 2010 Jul-Aug;17(4):473-9. doi:
      10.1016/j.jmig.2010.03.003. Epub 2010 May 23.


PMID- 20547028
OWN - NLM
STAT- MEDLINE
DCOM- 20110427
LR  - 20211028
IS  - 1873-5134 (Electronic)
IS  - 0738-3991 (Linking)
VI  - 82
IP  - 2
DP  - 2011 Feb
TI  - Is the routine recording of primary care consultations possible ... and
      desirable? Lessons for researchers from a consultation with multiple
      stakeholders.
PG  - 247-53
LID - 10.1016/j.pec.2010.04.020 [doi]
AB  - OBJECTIVE: To explore stakeholders' attitudes towards routine, longitudinal
      recording of primary care consultations for research purposes, and to identify
      legal, ethical, and practical barriers and facilitators. METHODS: 183
      stakeholders (including patients, researchers and practice staff) were identified
      using a purposeful sampling strategy. Stakeholders participated in focus groups
      and interviews. The data was analysed thematically in an iterative manner with
      themes and questions from earlier discussions being raised with later
      participants. RESULTS: Most participants supported the creation of a database and
      believed it would benefit patient care. They suggested it could be used to train 
      doctors, aid understanding of conditions, and feed information back to practices 
      to improve performance. However, enthusiasm was tempered by concerns about the
      ownership security and access of the data; quality and limitations of the
      dataset; impact on behaviour; and workload. Safeguards were suggested that
      protected vulnerable individuals, enabled participation, gave control to
      participants, and clarified data use. CONCLUSION: The findings show that
      collecting such longitudinal data is possible, valuable and acceptable providing 
      certain safeguards are in place. PRACTICE IMPLICATIONS: Future studies employing 
      routine recordings of consultations should: Attend to confidentiality, access and
      governance of the archive. Collect quality data, and store it securely.
CI  - Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Rushmer, Rosemary
AU  - Rushmer R
AD  - Centre for Public Policy and Health, School of Medicine and Health, Wolfson
      Research Institute, University of Durham, Stockton-on-Tees, UK.
      rosemary.rushmer@durham.ac.uk
FAU - Themessel-Huber, Mark
AU  - Themessel-Huber M
FAU - Coyle, Joanne
AU  - Coyle J
FAU - Humphris, Gerry
AU  - Humphris G
FAU - Dowell, Jon
AU  - Dowell J
FAU - Williams, Brian
AU  - Williams B
LA  - eng
GR  - NMAHP1/CSO_/Chief Scientist Office/United Kingdom
PT  - Journal Article
DEP - 20100523
PL  - Ireland
TA  - Patient Educ Couns
JT  - Patient education and counseling
JID - 8406280
MH  - Biomedical Research/*methods
MH  - Data Collection
MH  - Female
MH  - Focus Groups
MH  - Humans
MH  - Longitudinal Studies/methods
MH  - Male
MH  - *Physician-Patient Relations
MH  - Primary Health Care/*methods
MH  - Qualitative Research
MH  - Referral and Consultation/*statistics & numerical data
MH  - Research Design
MH  - Research Personnel/*statistics & numerical data
MH  - Surveys and Questionnaires
MH  - Tape Recording
MH  - Workload
EDAT- 2010/06/16 06:00
MHDA- 2011/04/28 06:00
CRDT- 2010/06/16 06:00
PHST- 2009/07/15 00:00 [received]
PHST- 2010/04/08 00:00 [revised]
PHST- 2010/04/22 00:00 [accepted]
PHST- 2010/06/16 06:00 [entrez]
PHST- 2010/06/16 06:00 [pubmed]
PHST- 2011/04/28 06:00 [medline]
AID - S0738-3991(10)00191-6 [pii]
AID - 10.1016/j.pec.2010.04.020 [doi]
PST - ppublish
SO  - Patient Educ Couns. 2011 Feb;82(2):247-53. doi: 10.1016/j.pec.2010.04.020. Epub
      2010 May 23.


PMID- 20546817
OWN - NLM
STAT- MEDLINE
DCOM- 20100831
LR  - 20220321
IS  - 1476-5616 (Electronic)
IS  - 0033-3506 (Linking)
VI  - 124
IP  - 5
DP  - 2010 May
TI  - Comorbidities, quality of life and patients' willingness to pay for a cure for
      type 2 diabetes in Taiwan.
PG  - 284-94
LID - 10.1016/j.puhe.2010.02.019 [doi]
AB  - OBJECTIVES: Diabetes is one of the leading causes of death in Taiwan. However, to
      date,no study has investigated the patient profile in this country.Therefore,this
      study aimed to analyse health condition,health-related quality of life and
      associated financial burden of people with diabetes in Taiwan. STUDY DESIGN: A
      cross-sectional survey was conducted using face-to-face interviews with patients 
      with diabetes aged 18 years and over from four hospitals in northern Taiwan. A
      hypothetical scenario was designed to ascertain subjects' willingness to pay for 
      a cure for diabetes. Ethical approval and consent were obtained from the patients
      and hospital ethics boards. METHODS: A double-bounded dichotomous contingent
      valuation method and maximum log- likelihood model were employed to evaluate the 
      cost of the disease in Taiwan. Anchoring effect .EQ-5D was employed to assess
      patients' health-related quality of life. RESULTS: The main comorbidities
      reported were hypertension(52.2%),cataract(34.3%)and loss of sight(24.3%).The
      total cost of disease borne by each patient with diabetes is US$3065.7 per
      year.The total cost of diabetes to society is approximately US$2.96 billion,
      equivalent to approximately 0.8% of the gross domestic product of Taiwan. The
      Bureau of National Health Insurance alleviates approximately one-third of the
      burden for patients. CONCLUSIONS: The presence of specific comorbidities for
      patients with diabetes does not have a significant impact on their willingness to
      pay for a cure. However, body mass index, health- related quality of life and
      ability to decrease blood glucose level were significantly associated with
      willingness to pay. With ever-increasing health expenditures around the
      world,cost containment should start with preventive approaches. Health policies
      regarding the prevention of diabetes should focus on the promotion of life
      quality and fitness of the patients.
FAU - Chang, K
AU  - Chang K
AD  - Department of Healthcare Information and Management, Ming Chuan University,
      Taoyuan, Taiwan, Republic of China. koyin@kchang.net
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Public Health
JT  - Public health
JID - 0376507
SB  - IM
MH  - Adult
MH  - Aged
MH  - Comorbidity
MH  - *Cost of Illness
MH  - Cross-Sectional Studies
MH  - Diabetes Complications/economics/*epidemiology
MH  - Diabetes Mellitus, Type 2/*economics/therapy
MH  - Female
MH  - Financing, Personal/*statistics & numerical data
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Middle Aged
MH  - *Patient Acceptance of Health Care
MH  - *Quality of Life
MH  - Regression Analysis
MH  - Surveys and Questionnaires
MH  - Taiwan
EDAT- 2010/06/16 06:00
MHDA- 2010/09/02 06:00
CRDT- 2010/06/16 06:00
PHST- 2009/07/28 00:00 [received]
PHST- 2010/01/28 00:00 [revised]
PHST- 2010/02/24 00:00 [accepted]
PHST- 2010/06/16 06:00 [entrez]
PHST- 2010/06/16 06:00 [pubmed]
PHST- 2010/09/02 06:00 [medline]
AID - S0033-3506(10)00057-0 [pii]
AID - 10.1016/j.puhe.2010.02.019 [doi]
PST - ppublish
SO  - Public Health. 2010 May;124(5):284-94. doi: 10.1016/j.puhe.2010.02.019.


PMID- 20546468
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20100615
IS  - 1365-2834 (Electronic)
IS  - 0966-0429 (Linking)
VI  - 18
IP  - 3
DP  - 2010 Apr
TI  - Negative workplace behaviours: an ethical dilemma for nurse managers.
PG  - 285-92
LID - 10.1111/j.1365-2834.2010.01080.x [doi]
AB  - AIMS: To discover nurse managers' perception of negative workplace behaviours
      (bullying) encountered by staff on their unit. Background Negative workplace
      behaviour is a worldwide phenomenon happening in all types of work settings.
      Absent from the literature were studies specific to the nurse managers'
      perception on this topic. METHODS: A phenomenological qualitative research
      methodology was used to gain insight into the perceptions of nurse managers about
      negative workplace behaviours that they have observed or addressed. RESULTS:
      Nurse Managers described their perceptions of, and experiences pertaining to,
      instances of negative workplace behaviour. Six themes emerged from the data
      analysis: 'that's just how she is', 'they just take it', 'a lot of things going
      on', 'old baggage', 'three sides to a story' and 'a management perspective'.
      CONCLUSION: Nurse Managers had observed, experienced and/or had received reports 
      of negative workplace behaviours. While some felt comfortable addressing the
      behaviour, others experienced ethical dilemmas when trying to treat all fairly.
      IMPLICATIONS: The results of the present study provide guidance for nurse
      managers to address negative workplace behaviours occurring on their units.
FAU - Lindy, Cheryl
AU  - Lindy C
AD  - St Luke's Epsicopal Hospital, Houston, TX 77030, USA. clindy@sleh.com
FAU - Schaefer, Florence
AU  - Schaefer F
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Nurs Manag
JT  - Journal of nursing management
JID - 9306050
MH  - Adaptation, Psychological
MH  - Adult
MH  - Aggression/*psychology
MH  - *Attitude of Health Personnel
MH  - Behavior
MH  - *Ethics, Nursing
MH  - Female
MH  - Group Processes
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nurse Administrators/*psychology
MH  - *Nursing, Supervisory
MH  - Occupational Diseases/prevention & control
MH  - Occupational Exposure
MH  - Organizational Culture
MH  - Perception
MH  - Qualitative Research
MH  - Stress, Psychological
MH  - Workplace/psychology
EDAT- 2010/06/16 06:00
MHDA- 2011/01/07 06:00
CRDT- 2010/06/16 06:00
PHST- 2010/06/16 06:00 [entrez]
PHST- 2010/06/16 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
AID - JNM1080 [pii]
AID - 10.1111/j.1365-2834.2010.01080.x [doi]
PST - ppublish
SO  - J Nurs Manag. 2010 Apr;18(3):285-92. doi: 10.1111/j.1365-2834.2010.01080.x.


PMID- 20546143
OWN - NLM
STAT- MEDLINE
DCOM- 20100929
LR  - 20151119
IS  - 1467-789X (Electronic)
IS  - 1467-7881 (Linking)
VI  - 11
IP  - 8
DP  - 2010 Aug
TI  - Ethical and public policy aspects of childhood obesity: opinions of scientists
      working on an intervention study.
PG  - 620-6
LID - 10.1111/j.1467-789X.2010.00752.x [doi]
AB  - Scientists working on an obesity intervention project were asked questions, via
      questionnaire and interviews, relating to ethical and public-policy aspects of
      tackling childhood obesity. The main areas of enquiry concerned elements
      responsible for the rise in childhood obesity, key ethical areas of obesity
      interventions, helpfulness and effectiveness of policy measures, socioeconomic
      factors, and media coverage and political debate. Key results from this indicate 
      that: there is disagreement about the amount of information about the causes of
      obesity that is needed before implementing interventions; an improvement in
      health and nutrition education of both children and adults through positive
      messages is seen as highly desirable; scientists regard environment, rather than 
      genetics, as playing the major role in rising obesity levels; the level of
      individual responsibility being placed on parents and children may be unfair and 
      unhelpful; whole-system, long-term and sensitive policy actions are needed rather
      than relying on quick fixes such as miracle pills; and there are country-specific
      issues related to rising obesity levels that need to be considered, though the
      respondents tended to have a great deal of faith in EU-wide interventions.
FAU - Wickins-Drazilova, D
AU  - Wickins-Drazilova D
AD  - Department of Philosophy, Lancaster University, Lancaster, UK.
      d.wickins-drazilova@lancaster.ac.uk
FAU - Williams, G
AU  - Williams G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100610
PL  - England
TA  - Obes Rev
JT  - Obesity reviews : an official journal of the International Association for the
      Study of Obesity
JID - 100897395
SB  - IM
MH  - Adult
MH  - Child
MH  - Child Nutrition Sciences/*education
MH  - Child Nutritional Physiological Phenomena/physiology
MH  - *Ethics, Clinical
MH  - Europe
MH  - Female
MH  - Health Education/*organization & administration
MH  - Humans
MH  - Life Style
MH  - Male
MH  - Obesity/epidemiology/etiology/*prevention & control
MH  - *Public Policy
MH  - Surveys and Questionnaires
EDAT- 2010/06/16 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/06/16 06:00
PHST- 2010/06/16 06:00 [entrez]
PHST- 2010/06/16 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - OBR752 [pii]
AID - 10.1111/j.1467-789X.2010.00752.x [doi]
PST - ppublish
SO  - Obes Rev. 2010 Aug;11(8):620-6. doi: 10.1111/j.1467-789X.2010.00752.x. Epub 2010 
      Jun 10.


PMID- 20545832
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20220318
IS  - 0022-4006 (Print)
IS  - 0022-4006 (Linking)
VI  - 70 Suppl 1
DP  - 2010 Jun
TI  - Attributes of an ideal oral health care system.
PG  - S6-14
LID - 10.1111/j.1752-7325.2010.00172.x [doi]
AB  - OBJECTIVES: The sense of urgency concerning the inadequacies of the current U.S. 
      oral health care system in better preventing oral diseases, eliminating oral
      health disparities, and ensuring access to basic oral health services has
      increased in recent years. This paper sought to articulate the attributes that an
      ideal oral health care system would possess, which would be consistent with the
      principles of the leading authorities on the public's health. METHODS: The
      authors reviewed policy statements and position papers of the World Health
      Organization, The Institute of Medicine, The American Public Health Association, 
      Healthy People 2010 Objectives for the Nation, and the American Association of
      Public Health Dentistry. RESULTS: Consistent with leading public health
      authorities, an ideal oral health care system would be have the following
      attributes: integration with the rest of the health care system; emphasis on
      health promotion and disease prevention; monitoring of population oral health
      status and needs; evidence-based; effective; cost-effective; sustainable;
      equitable; universal; comprehensive; ethical; includes continuous quality
      assessment and assurance; culturally competent; and empowers communities and
      individuals to create conditions conducive to health. CONCLUSIONS: Although there
      are some attributes of an ideal oral health care system on which the United
      States has made initial strides, it falls far short in many areas. The
      development of an oral health care delivery system that meets the characteristics
      described above is possible but would require tremendous commitment and political
      will on the part of the American public and its elected officials to bring it to 
      fruition.
FAU - Tomar, Scott L
AU  - Tomar SL
AD  - University of Florida College of Dentistry, Department of Community Dentistry and
      Behavioral Science, 1329 SW 16th Street, Suite 5180, PO Box 103628, Gainesville, 
      FL 32610-3628, USA. stomar@dental.ufl.edu
FAU - Cohen, Lois K
AU  - Cohen LK
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Public Health Dent
JT  - Journal of public health dentistry
JID - 0014207
SB  - IM
MH  - Cultural Competency
MH  - Delivery of Health Care, Integrated/organization & administration/*standards
MH  - Dental Care/*standards
MH  - Ethics, Dental
MH  - Evidence-Based Dentistry
MH  - Health Policy
MH  - Humans
MH  - Oral Health/*standards
MH  - Preventive Dentistry/standards
MH  - Public Health Dentistry/economics/organization & administration/*standards
MH  - Quality Assurance, Health Care
MH  - United States
MH  - Universal Health Insurance
MH  - Workforce
EDAT- 2010/06/16 06:00
MHDA- 2010/09/16 06:00
CRDT- 2010/06/16 06:00
PHST- 2010/06/16 06:00 [entrez]
PHST- 2010/06/16 06:00 [pubmed]
PHST- 2010/09/16 06:00 [medline]
AID - JPHD172 [pii]
AID - 10.1111/j.1752-7325.2010.00172.x [doi]
PST - ppublish
SO  - J Public Health Dent. 2010 Jun;70 Suppl 1:S6-14. doi:
      10.1111/j.1752-7325.2010.00172.x.


PMID- 20544838
OWN - NLM
STAT- MEDLINE
DCOM- 20101020
LR  - 20100909
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 116
IP  - 18
DP  - 2010 Sep 15
TI  - Human papillomavirus status in head and neck cancer: the ethics of disclosure.
PG  - 4221-6
LID - 10.1002/cncr.25210 [doi]
AB  - Human papillomavirus (HPV) is an emerging causative factor for squamous carcinoma
      of the oropharynx and perhaps other head and neck cancers. There is a great deal 
      of uncertainty regarding the clinical significance and implications of HPV status
      in this patient population. As a result, there is no established protocol for
      informing patients of the potential link between viral infection and their
      cancer. This paper discusses some of the ethical issues involved with informing
      head and neck cancer patients of their HPV status, recognizing the dilemma posed 
      by unresolved clinical questions and the need to respect the autonomy of patients
      by disclosing relevant information.
CI  - (c) 2010 American Cancer Society.
FAU - Shuman, Andrew G
AU  - Shuman AG
AD  - Department of Otolaryngology-Head and Neck Surgery, University of Michigan
      Medical School, Ann Arbor, Michigan, USA. shumana@umich.edu
FAU - Wolf, Gregory T
AU  - Wolf GT
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
RN  - 0 (Papillomavirus Vaccines)
SB  - IM
MH  - *Ethics, Medical
MH  - Female
MH  - Head and Neck Neoplasms/*virology
MH  - Humans
MH  - Neoplasms, Squamous Cell/*virology
MH  - Otorhinolaryngologic Neoplasms/*virology
MH  - Papillomavirus Infections/*psychology/transmission
MH  - Papillomavirus Vaccines/administration & dosage
MH  - Prognosis
MH  - Risk
MH  - Sexually Transmitted Diseases/prevention & control/virology
MH  - *Truth Disclosure
MH  - Uterine Cervical Neoplasms/virology
MH  - Vaccination/ethics
EDAT- 2010/06/15 06:00
MHDA- 2010/10/21 06:00
CRDT- 2010/06/15 06:00
PHST- 2010/06/15 06:00 [entrez]
PHST- 2010/06/15 06:00 [pubmed]
PHST- 2010/10/21 06:00 [medline]
AID - 10.1002/cncr.25210 [doi]
PST - ppublish
SO  - Cancer. 2010 Sep 15;116(18):4221-6. doi: 10.1002/cncr.25210.


PMID- 20544800
OWN - NLM
STAT- MEDLINE
DCOM- 20150623
LR  - 20180116
IS  - 1939-0041 (Electronic)
IS  - 1939-0041 (Linking)
VI  - 3
IP  - 2
DP  - 2011 Mar-Apr
TI  - Nanomedicine and ethics: is there anything new or unique?
PG  - 111-118
LID - 10.1002/wnan.90 [doi]
AB  - As medicine moves toward being able to predict what you will die from and when,
      nanomedicine is expected to enhance human capabilities and properties and
      promises the ability of health care professionals to diagnose, treat, and share
      medical information nearly instantaneously. It promises to deliver drugs directly
      to the source of the disease, i.e. tumor. This article examines the literature
      surrounding ethics associated with nanomedicine, and asks whether these ethical
      issues are new and unique. While opinions differ, this review concludes that none
      of the ethical questions surrounding nanomedicine are new or unique, and would
      hold true for any new medical device or medicine that was being evaluated. The
      real issue becomes public acceptance of nanomedicine and how much risk society is
      willing to accept with a new technology before it is proven effective and 'safe'.
      While ethical foresight can prove effective in forecasting potential problems, in
      reality, ethics may not be capable of evaluating such a technology that has yet
      proven effective in all it has promised.
CI  - Copyright (c) 2010 John Wiley & Sons, Inc.
FAU - Kuiken, Todd
AU  - Kuiken T
AD  - Woodrow Wilson International Center for Scholars, One Woodrow Wilson Plaza, 1300 
      Pennsylvania Avenue, NW, Washington, DC, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100420
PL  - United States
TA  - Wiley Interdiscip Rev Nanomed Nanobiotechnol
JT  - Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
JID - 101508311
SB  - IM
MH  - Humans
MH  - Nanomedicine/*ethics
EDAT- 2010/06/15 06:00
MHDA- 2015/06/24 06:00
CRDT- 2010/06/15 06:00
PHST- 2010/06/15 06:00 [entrez]
PHST- 2010/06/15 06:00 [pubmed]
PHST- 2015/06/24 06:00 [medline]
AID - 10.1002/wnan.90 [doi]
PST - ppublish
SO  - Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2011 Mar-Apr;3(2):111-118. doi:
      10.1002/wnan.90. Epub 2010 Apr 20.


PMID- 20544288
OWN - NLM
STAT- MEDLINE
DCOM- 20110207
LR  - 20190114
IS  - 1573-2665 (Electronic)
IS  - 0141-8955 (Linking)
VI  - 33
IP  - Suppl 2
DP  - 2010 Oct
TI  - Expanded newborn screening: social and ethical issues.
PG  - S211-7
LID - 10.1007/s10545-010-9138-y [doi]
AB  - Newborn screening and genetic testing have expanded rapidly in the last decade
      with the advent of multiplex (e.g., tandem mass spectrometry) and/or DNA
      technologies. However, screening panels include a large number of disorders,
      which may not meet all of the traditional screening criteria, established in late
      1960s, and used for years to justify screening programs. After a period of
      expansion driven by technological advances, many reports have reconsidered the
      justification of expanded programs. Many factors have contributed to test-panel
      discrepancies between countries. The test-panel review methodology, the way
      health benefits are weighed against harms, and the socioeconomic-political
      environment all play a role. Expansion of screening also requires reconsideration
      of the infrastructure (ideally, in the context of national plans for rare
      diseases) to support testing, counselling, education, treatment, and follow-up.
      Consequently, economic aspects cannot be ignored and can be a limitation for
      expansion. New ethical questions have emerged: risks of discrimination or
      stigmatization, respect of the autonomy of persons to make decisions, parental
      anxiety resulting from a false positive test (especially when reporting to
      parents screening results for untreatable conditions identified as by-products of
      screening), etc. For disorders where there is not yet confirmation of benefit, it
      may be prudent to recommend pilot screening and to have a mechanism that can be
      used to adapt or even to stop a program.
FAU - Dhondt, Jean-Louis
AU  - Dhondt JL
AD  - AFDPHE (French Association for Neonatal screening) and Laboratoire, Hopital
      StPhilibert, 115 rue du grand but., Lomme cedex, France.
      Dhondt.jeanlouis@ghicl.net
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100611
PL  - United States
TA  - J Inherit Metab Dis
JT  - Journal of inherited metabolic disease
JID - 7910918
SB  - IM
MH  - Anxiety
MH  - False Positive Reactions
MH  - Humans
MH  - Infant, Newborn
MH  - Informed Consent
MH  - Metabolism, Inborn Errors/*diagnosis/therapy
MH  - Neonatal Screening/adverse effects/economics/*ethics
MH  - Parents/psychology
MH  - Predictive Value of Tests
MH  - Prejudice
MH  - Prognosis
MH  - Rare Diseases/*diagnosis/therapy
MH  - Risk Assessment
MH  - Risk Factors
MH  - *Social Behavior
MH  - Stereotyping
EDAT- 2010/06/15 06:00
MHDA- 2011/02/08 06:00
CRDT- 2010/06/15 06:00
PHST- 2009/12/15 00:00 [received]
PHST- 2010/05/19 00:00 [accepted]
PHST- 2010/05/06 00:00 [revised]
PHST- 2010/06/15 06:00 [entrez]
PHST- 2010/06/15 06:00 [pubmed]
PHST- 2011/02/08 06:00 [medline]
AID - 10.1007/s10545-010-9138-y [doi]
PST - ppublish
SO  - J Inherit Metab Dis. 2010 Oct;33(Suppl 2):S211-7. doi: 10.1007/s10545-010-9138-y.
      Epub 2010 Jun 11.


PMID- 20543951
OWN - NLM
STAT- MEDLINE
DCOM- 20100901
LR  - 20211020
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 5
IP  - 6
DP  - 2010 Jun 9
TI  - Altered ratio of D1 and D2 dopamine receptors in mouse striatum is associated
      with behavioral sensitization to cocaine.
PG  - e11038
LID - 10.1371/journal.pone.0011038 [doi]
AB  - BACKGROUND: Drugs of abuse elevate brain dopamine levels, and, in vivo, chronic
      drug use is accompanied by a selective decrease in dopamine D2 receptor (D2R)
      availability in the brain. Such a decrease consequently alters the ratio of
      D1R:D2R signaling towards the D1R. Despite a plethora of behavioral studies
      dedicated to the understanding of the role of dopamine in addiction, a molecular 
      mechanism responsible for the downregulation of the D2R, in vivo, in response to 
      chronic drug use has yet to be identified. METHODS AND FINDINGS: ETHICS
      STATEMENT: All animal work was approved by the Gallo Center IACUC committee and
      was performed in our AAALAC approved facility. In this study, we used wild type
      (WT) and G protein coupled receptor associated sorting protein-1 (GASP-1) knock
      out (KO) mice to assess molecular changes that accompany cocaine sensitization.
      Here, we show that downregulation of D2Rs or upregulation of D1Rs is associated
      with a sensitized locomotor response to an acute injection of cocaine.
      Furthermore, we demonstrate that disruption of GASP-1, that targets D2Rs for
      degradation after endocytosis, prevents cocaine-induced downregulation of D2Rs.
      As a consequence, mice with a GASP-1 disruption show a reduction in the
      sensitized locomotor response to cocaine. CONCLUSIONS: Together, our data
      suggests that changes in the ratio of the D1:D2R could contribute to
      cocaine-induced behavioral plasticity and demonstrates a role of GASP-1 in
      regulating both the levels of the D2R and cocaine sensitization.
FAU - Thompson, Dawn
AU  - Thompson D
AD  - Ernest Gallo Clinic and Research Center, University of California San Francisco, 
      Emeryville, California, USA.
FAU - Martini, Lene
AU  - Martini L
FAU - Whistler, Jennifer L
AU  - Whistler JL
LA  - eng
GR  - R01 MH068442/MH/NIMH NIH HHS/United States
GR  - MH068442-01/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20100609
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Carrier Proteins)
RN  - 0 (Gprasp1 protein, mouse)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Receptors, Dopamine D1)
RN  - 0 (Receptors, Dopamine D2)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Carrier Proteins/genetics/physiology
MH  - Cocaine/*pharmacology
MH  - Corpus Striatum/*drug effects/metabolism
MH  - Down-Regulation
MH  - Intracellular Signaling Peptides and Proteins
MH  - Mice
MH  - Mice, Knockout
MH  - Receptors, Dopamine D1/*metabolism
MH  - Receptors, Dopamine D2/*metabolism
PMC - PMC2882949
EDAT- 2010/06/15 06:00
MHDA- 2010/09/02 06:00
CRDT- 2010/06/15 06:00
PHST- 2009/12/07 00:00 [received]
PHST- 2010/04/07 00:00 [accepted]
PHST- 2010/06/15 06:00 [entrez]
PHST- 2010/06/15 06:00 [pubmed]
PHST- 2010/09/02 06:00 [medline]
AID - 10.1371/journal.pone.0011038 [doi]
PST - epublish
SO  - PLoS One. 2010 Jun 9;5(6):e11038. doi: 10.1371/journal.pone.0011038.


PMID- 20543673
OWN - NLM
STAT- MEDLINE
DCOM- 20101021
LR  - 20220318
IS  - 1473-6322 (Electronic)
IS  - 1473-6322 (Linking)
VI  - 10
IP  - 4
DP  - 2010 Aug
TI  - Epinephrine and its use in anaphylaxis: current issues.
PG  - 354-61
LID - 10.1097/ACI.0b013e32833bc670 [doi]
AB  - PURPOSE OF REVIEW: Epinephrine is a life-saving medication in the treatment of
      anaphylaxis, in which it has multiple beneficial pharmacologic effects. Here, we 
      examine the evidence base for its primary role in the treatment of anaphylaxis
      episodes in community settings. RECENT FINDINGS: We review the practical
      pharmacology of epinephrine in anaphylaxis, its intrinsic limitations, and the
      pros and cons of different routes of administration. We provide a new perspective
      on the adverse effects of epinephrine, including its cardiac effects. We describe
      the evidence base for the use of epinephrine in anaphylaxis. We discuss the role 
      of epinephrine auto-injectors for treatment of anaphylaxis in community settings,
      including identification of patients who need an auto-injector prescription,
      current use of auto-injectors, and advances in auto-injector design. We list
      reasons why physicians fail to prescribe epinephrine auto-injectors for patients 
      with anaphylaxis, and reasons why patients fail to self-inject epinephrine in
      anaphylaxis. We emphasize the primary role of epinephrine in the context of
      emergency preparedness for anaphylaxis in the community. SUMMARY: Epinephrine is 
      the medication of choice in the first-aid treatment of anaphylaxis in the
      community. For ethical reasons, it is not possible to conduct randomized,
      placebo-controlled trials of epinephrine in anaphylaxis; however, continued
      efforts are needed towards improving the evidence base for epinephrine injection 
      in this potentially fatal disease.
FAU - Simons, Keith J
AU  - Simons KJ
AD  - Faculty of Pharmacy and Department of Pediatrics & Child Health, Faculty of
      Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
FAU - Simons, F Estelle R
AU  - Simons FE
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Allergy Clin Immunol
JT  - Current opinion in allergy and clinical immunology
JID - 100936359
RN  - 0 (Adrenergic Agonists)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Adolescent
MH  - Adrenergic Agonists/administration & dosage/adverse effects/*therapeutic use
MH  - Adult
MH  - Aged
MH  - Anaphylaxis/*prevention & control
MH  - Animals
MH  - Child
MH  - Epinephrine/administration & dosage/adverse effects/*therapeutic use
MH  - Humans
MH  - Infant
MH  - Injections, Intramuscular/instrumentation
MH  - Middle Aged
MH  - Self Administration
EDAT- 2010/06/15 06:00
MHDA- 2010/10/22 06:00
CRDT- 2010/06/15 06:00
PHST- 2010/06/15 06:00 [entrez]
PHST- 2010/06/15 06:00 [pubmed]
PHST- 2010/10/22 06:00 [medline]
AID - 10.1097/ACI.0b013e32833bc670 [doi]
PST - ppublish
SO  - Curr Opin Allergy Clin Immunol. 2010 Aug;10(4):354-61. doi:
      10.1097/ACI.0b013e32833bc670.


PMID- 20543620
OWN - NLM
STAT- MEDLINE
DCOM- 20101207
LR  - 20100614
IS  - 1538-8646 (Electronic)
IS  - 0730-4625 (Linking)
VI  - 29
IP  - 4
DP  - 2010 Jul-Aug
TI  - A brief review of the Belmont report.
PG  - 173-4
LID - 10.1097/DCC.0b013e3181de9ec5 [doi]
AB  - The Belmont Report is one of the leading works concerning ethics and health care 
      research. Its primary purpose is to protect subjects and participants in clinical
      trials or research studies. This report consists of 3 principles: beneficence,
      justice, and respect for persons. This article reviews the Belmont Report and
      these 3 principles as well as its importance to nurse researchers.
FAU - Sims, Jennifer M
AU  - Sims JM
AD  - JennyARNP@yahoo.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Dimens Crit Care Nurs
JT  - Dimensions of critical care nursing : DCCN
JID - 8211489
MH  - *Beneficence
MH  - Clinical Trials as Topic/*ethics
MH  - Critical Care/*ethics
MH  - Ethics, Research
MH  - Humans
MH  - Nursing Care/*ethics
MH  - *Personal Autonomy
MH  - Research Subjects
MH  - *Social Justice
MH  - United States
EDAT- 2010/06/15 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/06/15 06:00
PHST- 2010/06/15 06:00 [entrez]
PHST- 2010/06/15 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1097/DCC.0b013e3181de9ec5 [doi]
AID - 00003465-201007000-00007 [pii]
PST - ppublish
SO  - Dimens Crit Care Nurs. 2010 Jul-Aug;29(4):173-4. doi:
      10.1097/DCC.0b013e3181de9ec5.


PMID- 20543604
OWN - NLM
STAT- MEDLINE
DCOM- 20100915
LR  - 20220330
IS  - 1746-6318 (Electronic)
IS  - 1746-630X (Linking)
VI  - 5
IP  - 4
DP  - 2010 Jul
TI  - Highly active antiretroviral treatment as prevention of HIV transmission: review 
      of scientific evidence and update.
PG  - 298-304
LID - 10.1097/COH.0b013e32833a6c32 [doi]
AB  - PURPOSE OF REVIEW: An estimated 33 million people are living with HIV and
      universal access remains a dream for millions of people. By the end of year 2008,
      four million people were on treatment; however, over five million needed
      treatment, and in 2007, there were 2.7 million new infections. Without
      significant improvement in prevention, we are unlikely to meet universal access
      targets including the growing demand for highly active antiretroviral treatment
      (HAART). This review examines HAART as a potential tool for preventing HIV
      transmission. RECENT FINDINGS: We discuss recent scientific evidence regarding
      the treatment and prevention gap, importance viral load and HIV transmission,
      HAART and HIV transmission, when to start, HIV counseling and testing, modeling
      results and next steps. SUMMARY: HAART has considerable treatment and prevention 
      benefits and it needs to be considered as a key element of combination
      prevention. To explore HAART as an effective prevention strategy, we recommend
      further evaluation of human rights and ethical considerations, clarification of
      research priorities and exploration of feasibility and acceptability issues.
FAU - Granich, Reuben
AU  - Granich R
AD  - Antiretroviral Treatment and HIV Care Unit, Department of HIV/AIDS, World Health 
      Organization, Geneva, Switzerland. granichr@who.int
FAU - Crowley, Siobhan
AU  - Crowley S
FAU - Vitoria, Marco
AU  - Vitoria M
FAU - Smyth, Caoimhe
AU  - Smyth C
FAU - Kahn, James G
AU  - Kahn JG
FAU - Bennett, Rod
AU  - Bennett R
FAU - Lo, Ying-Ru
AU  - Lo YR
FAU - Souteyrand, Yves
AU  - Souteyrand Y
FAU - Williams, Brian
AU  - Williams B
LA  - eng
GR  - R01 DA015612/DA/NIDA NIH HHS/United States
GR  - R01 DA015612-09/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin HIV AIDS
JT  - Current opinion in HIV and AIDS
JID - 101264945
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - Anti-HIV Agents/*therapeutic use
MH  - Antiretroviral Therapy, Highly Active/*methods
MH  - Chemoprevention/methods
MH  - HIV Infections/*drug therapy/*prevention & control/virology
MH  - Humans
MH  - Time Factors
MH  - Viral Load
RF  - 77
PMC - PMC3501989
MID - NIHMS341428
EDAT- 2010/06/15 06:00
MHDA- 2010/09/16 06:00
CRDT- 2010/06/15 06:00
PHST- 2010/06/15 06:00 [entrez]
PHST- 2010/06/15 06:00 [pubmed]
PHST- 2010/09/16 06:00 [medline]
AID - 10.1097/COH.0b013e32833a6c32 [doi]
AID - 01222929-201007000-00007 [pii]
PST - ppublish
SO  - Curr Opin HIV AIDS. 2010 Jul;5(4):298-304. doi: 10.1097/COH.0b013e32833a6c32.


PMID- 20543447
OWN - NLM
STAT- MEDLINE
DCOM- 20101005
LR  - 20100614
IS  - 0926-9630 (Print)
IS  - 0926-9630 (Linking)
VI  - 159
DP  - 2010
TI  - Enabling secure, distributed collaborations for adrenal tumor research.
PG  - 259-63
AB  - Many e-Health strategies rely on the secure integration of datasets that have
      previously resided in isolated locations, but can now in principle be accessed
      over the Internet. Of paramount importance in the health domain is the need for
      the security and privacy of data that is transmitted across these networks. One
      such collaboration, which spans several specialist centres across France,
      Germany, Italy and the UK, is ENSAT - the European Network for the Study of
      Adrenal Tumors. The rarity of the tumors under study means the value of
      accessing, aggregating and comparing data from many centres is great indeed.
      However this is especially challenging given that ENSAT require clinical and
      genomic data to be seamlessly linked, but in such a way that the information
      governance, ethics and privacy concerns of the patients and associated
      stakeholders involved are visibly satisfied. Key to this is the clear separation 
      of clinical and genomic data sets and support for rigorous patient-identity
      protecting access control. This is especially challenging when such data sets
      exist across different organisational boundaries. In this paper we describe a
      prototype solution offering a security-oriented tailored portal supported by a
      layered encryption-driven linkage technology (VANGUARD) that offers precisely
      such patient-privacy protecting capabilities. We describe the architecture,
      implementation and use to date of this facility to support the ENSAT adrenal
      cancer research network.
FAU - Stell, Anthony
AU  - Stell A
AD  - National e-Science Centre, University of Glasgow, UK.
FAU - Sinnott, Richard
AU  - Sinnott R
FAU - Jiang, Jipu
AU  - Jiang J
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Stud Health Technol Inform
JT  - Studies in health technology and informatics
JID - 9214582
MH  - Access to Information
MH  - Adrenal Glands/*physiopathology
MH  - *Biomedical Research
MH  - Computer Security
MH  - *Cooperative Behavior
MH  - Europe
MH  - Humans
MH  - *Neoplasms
MH  - *Public Health Informatics
EDAT- 2010/06/15 06:00
MHDA- 2010/10/06 06:00
CRDT- 2010/06/15 06:00
PHST- 2010/06/15 06:00 [entrez]
PHST- 2010/06/15 06:00 [pubmed]
PHST- 2010/10/06 06:00 [medline]
PST - ppublish
SO  - Stud Health Technol Inform. 2010;159:259-63.


PMID- 20543423
OWN - NLM
STAT- MEDLINE
DCOM- 20101005
LR  - 20100614
IS  - 0926-9630 (Print)
IS  - 0926-9630 (Linking)
VI  - 159
DP  - 2010
TI  - Privacy aware access controls for medical data disclosure on European
      healthgrids.
PG  - 14-27
AB  - To be processed within a healthgrid environment, medical data goes through a
      complete lifecycle and several stages until it is finally used for the primary
      reason it has been collected for. This stage is not always the final occurrence
      of when the data would have been manipulated. The data could rather continue to
      be needed for secondary purposes of legitimate or non legitimate nature. Although
      other privacy issues are related to the processing of patient data while it is
      residing on a healthgrid environment, the control of data disclosure is our
      primary interest. When sharing medical data between different Healthcare and
      biomedical research organizations in Europe, it is important that the different
      parties involved in the sharing handle the data in the same way indicated by the 
      legislation of the member state where the data was originally collected as the
      requirements might differ from one state to another. Privacy requirements, such
      as patient consent, may be subject to conflicting conditions between different
      national frameworks as well as between different legal and ethical frameworks
      within a single member state. These circumstances have made the compliance
      management process in European healthgrid very challenging. In this paper we are 
      presenting an approach to tackle these issues by relying on several technologies 
      contained in the semantic web stack. Our work suggests a direct mapping from high
      level legislation on privacy and data protection to operational level privacy
      aware controls. Additionally we suggest an architecture for the enforcement of
      these controls on access control models adopted by healthgrids security
      infrastructures.
FAU - Rahmouni, Hanene Boussi
AU  - Rahmouni HB
AD  - Bristol Institute of Technology, UWE, Bristol/BS16 1QY.
      Hanene2.Rahmouni@uwe.ac.uk
FAU - Solomonides, Tony
AU  - Solomonides T
FAU - Mont, Marco Casassa
AU  - Mont MC
FAU - Shiu, Simon
AU  - Shiu S
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Stud Health Technol Inform
JT  - Studies in health technology and informatics
JID - 9214582
MH  - *Access to Information
MH  - *Computer Communication Networks
MH  - *Computer Security
MH  - *Confidentiality
MH  - Disclosure
MH  - Europe
MH  - *Medical Informatics
EDAT- 2010/06/15 06:00
MHDA- 2010/10/06 06:00
CRDT- 2010/06/15 06:00
PHST- 2010/06/15 06:00 [entrez]
PHST- 2010/06/15 06:00 [pubmed]
PHST- 2010/10/06 06:00 [medline]
PST - ppublish
SO  - Stud Health Technol Inform. 2010;159:14-27.


PMID- 20543390
OWN - NLM
STAT- MEDLINE
DCOM- 20100902
LR  - 20100614
IS  - 0926-9630 (Print)
IS  - 0926-9630 (Linking)
VI  - 157
DP  - 2010
TI  - Socio-technical challenges in implementing safe patient handovers.
PG  - 206-12
AB  - Ineffective handovers in patient care, including those where information loss
      occurs between care providers, have been identified as a risk to patient safety. 
      Computerization of health information is often offered as a solution to improve
      the quality of care handovers and decrease adverse events related to patient
      safety. Drawing on three ethnographic case studies we identify and discuss
      socio-technical issues which must be addressed if computerized health information
      systems are to achieve improvements in patient safety related to handovers in
      care. We suggest that the contextual nature of information, ethical and
      medico-legal issues arising in relation to information handover and data
      standards and system integration warrant ongoing research in socio-technical
      aspects of care handovers.
FAU - Balka, Ellen
AU  - Balka E
AD  - School of Communication, Simon Fraser University, Canada.
FAU - Tolar, Marianne
AU  - Tolar M
FAU - Coates, Shannon
AU  - Coates S
FAU - Whitehouse, Sandra
AU  - Whitehouse S
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Stud Health Technol Inform
JT  - Studies in health technology and informatics
JID - 9214582
MH  - *Continuity of Patient Care
MH  - *Hospital Information Systems
MH  - Humans
MH  - Medical Errors/prevention & control
MH  - Medical Records Systems, Computerized
MH  - Patient Transfer/*organization & administration
MH  - *Program Development
MH  - *Safety Management
EDAT- 2010/06/15 06:00
MHDA- 2010/09/03 06:00
CRDT- 2010/06/15 06:00
PHST- 2010/06/15 06:00 [entrez]
PHST- 2010/06/15 06:00 [pubmed]
PHST- 2010/09/03 06:00 [medline]
PST - ppublish
SO  - Stud Health Technol Inform. 2010;157:206-12.


PMID- 20543358
OWN - NLM
STAT- MEDLINE
DCOM- 20100902
LR  - 20100614
IS  - 0926-9630 (Print)
IS  - 0926-9630 (Linking)
VI  - 156
DP  - 2010
TI  - Rules and access rights of the Estonian integrated e-Health system.
PG  - 245-56
AB  - There should be a clear understanding that when implementing an electronic health
      record system (EHR), one of the hardest problems we have to solve is the access
      rights. In Estonia this process lasted for three years and involved all
      stakeholders of the healthcare sector. Special ethical committee was established 
      to advise the decision makers and doctors to help them understand the ethical
      dilemmas from the patient's and society's point of view. In this article you will
      find a short overview of the access rights of the system, roles of the healthcare
      systems' employees. Descriptions of some specific situations like underage
      patients and representation of patient with restricted active legal capacity.
FAU - Tiik, Madis
AU  - Tiik M
AD  - Tartu University, Estonian E-Health Foundation. madis@e-tervis.ee
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Stud Health Technol Inform
JT  - Studies in health technology and informatics
JID - 9214582
MH  - Access to Information/*legislation & jurisprudence
MH  - Electronic Health Records/*legislation & jurisprudence
MH  - Estonia
MH  - Humans
MH  - *Patient Rights
EDAT- 2010/06/15 06:00
MHDA- 2010/09/03 06:00
CRDT- 2010/06/15 06:00
PHST- 2010/06/15 06:00 [entrez]
PHST- 2010/06/15 06:00 [pubmed]
PHST- 2010/09/03 06:00 [medline]
PST - ppublish
SO  - Stud Health Technol Inform. 2010;156:245-56.


PMID- 20542987
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20211203
IS  - 1460-2083 (Electronic)
IS  - 0964-6906 (Linking)
VI  - 19
IP  - 17
DP  - 2010 Sep 1
TI  - Contribution of human amniotic fluid stem cells to renal tissue formation depends
      on mTOR.
PG  - 3320-31
LID - 10.1093/hmg/ddq236 [doi]
AB  - Human amniotic fluid stem cells (hAFSCs) can be grown in large quantities, have a
      low risk for tumour development and harbour a high differentiation potential.
      They are a very promising new fetal stem cell type for cell-based therapy
      approaches and for studying differentiation processes without raising the ethical
      concerns associated with embryonic stem cells. Recently, a protocol for studies
      on renal development has been established in which murine embryonic kidneys are
      dissociated into single-cell suspension and then reaggregated to form organotypic
      renal structures. Using this approach, we formed chimeric renal structures via
      mixing murine embryonic kidney cells with monoclonal hAFSCs. We demonstrate here 
      that hAFSCs harbour the potential to contribute to renal tissue formation
      accompanied by induction of specific renal marker expression. As part of the two 
      kinase complexes mTORC1 and mTORC2, mammalian target of rapamycin (mTOR) is the
      key component of an important signalling pathway, which is involved in the
      regulation of differentiation and in the development of a wide variety of human
      genetic diseases many with characteristic kidney symptoms. Modulating endogenous 
      mTOR activity via specific siRNA approaches revealed that contribution of hAFSCs 
      to renal tissue formation is regulated by mTORC1 and mTORC2. These findings (i)
      demonstrate renal differentiation potential of hAFSCs, (ii) prove chimeric
      cultures of mixtures of murine embryonic kidney cells and hAFSCs to be a powerful
      tool to study the effects of gene knockdowns for renal structure formation and
      (iii) provide new insights into the role of the mTOR pathway for renal
      development.
FAU - Siegel, Nicol
AU  - Siegel N
AD  - Institute of Medical Genetics, Medical University of Vienna, Wahringer Strasse
      10, 1090 Vienna, Austria.
FAU - Rosner, Margit
AU  - Rosner M
FAU - Unbekandt, Mathieu
AU  - Unbekandt M
FAU - Fuchs, Christiane
AU  - Fuchs C
FAU - Slabina, Nina
AU  - Slabina N
FAU - Dolznig, Helmut
AU  - Dolznig H
FAU - Davies, Jamie A
AU  - Davies JA
FAU - Lubec, Gert
AU  - Lubec G
FAU - Hengstschlager, Markus
AU  - Hengstschlager M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100611
PL  - England
TA  - Hum Mol Genet
JT  - Human molecular genetics
JID - 9208958
RN  - 0 (Crtc1 protein, mouse)
RN  - 0 (Crtc2 protein, mouse)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.1.1 (mTOR protein, mouse)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Amniotic Fluid/*cytology/metabolism
MH  - Animals
MH  - Cell Differentiation
MH  - Cells, Cultured
MH  - Embryonic Stem Cells/cytology/*metabolism
MH  - Female
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins/genetics/*metabolism
MH  - Kidney/*embryology/metabolism
MH  - Male
MH  - Mice
MH  - Protein Serine-Threonine Kinases/genetics/*metabolism
MH  - TOR Serine-Threonine Kinases
MH  - Trans-Activators/genetics/metabolism
MH  - Transcription Factors/genetics/metabolism
EDAT- 2010/06/15 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/06/15 06:00
PHST- 2010/06/15 06:00 [entrez]
PHST- 2010/06/15 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - ddq236 [pii]
AID - 10.1093/hmg/ddq236 [doi]
PST - ppublish
SO  - Hum Mol Genet. 2010 Sep 1;19(17):3320-31. doi: 10.1093/hmg/ddq236. Epub 2010 Jun 
      11.


PMID- 20542946
OWN - NLM
STAT- MEDLINE
DCOM- 20100820
LR  - 20211203
IS  - 1093-6793 (Print)
IS  - 1093-6793 (Linking)
VI  - 38
IP  - 2
DP  - 2010
TI  - Whose DNA is it anyway? European court, junk DNA, and the problem with
      prediction.
PG  - 247-50
AB  - In this article, we discuss the implications of a recent European Court of Human 
      Rights (ECHR) decision about the use of retained DNA profiles in criminal cases. 
      Met with polar but equal passion from both the privacy lobby and law enforcement,
      this case has opened concerns regarding ethics in the nascent science of DNA
      profiling. Although the technology is touted as the most exciting breakthrough
      since fingerprinting in crime solving, there are questions regarding its use. The
      case decided by the ECHR intensified the debate on privacy, state control of
      information, and the public's right to be safe. New proposals in response,
      however, raise more questions than they sought to answer, ranging from unfettered
      data mining to the pitfalls in risk prediction.
FAU - Sarkar, Sameer P
AU  - Sarkar SP
AD  - PO Box 3544, Wokingham, Berkshire, RG40 9FA, UK. spsarkar@talktalk.net
FAU - Adshead, Gwen
AU  - Adshead G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Acad Psychiatry Law
JT  - The journal of the American Academy of Psychiatry and the Law
JID - 9708963
RN  - 0 (DNA, Mitochondrial)
SB  - IM
MH  - *Cross-Cultural Comparison
MH  - DNA Fingerprinting/*legislation & jurisprudence
MH  - DNA, Mitochondrial/genetics
MH  - Ethnicity/legislation & jurisprudence
MH  - Europe
MH  - Expert Testimony/*legislation & jurisprudence
MH  - Genetic Privacy/*legislation & jurisprudence
MH  - Human Rights/*legislation & jurisprudence
MH  - Humans
MH  - Microsatellite Repeats/genetics
MH  - Phenotype
EDAT- 2010/06/15 06:00
MHDA- 2010/08/21 06:00
CRDT- 2010/06/15 06:00
PHST- 2010/06/15 06:00 [entrez]
PHST- 2010/06/15 06:00 [pubmed]
PHST- 2010/08/21 06:00 [medline]
AID - 38/2/247 [pii]
PST - ppublish
SO  - J Am Acad Psychiatry Law. 2010;38(2):247-50.


PMID- 20542695
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20161125
IS  - 1532-3080 (Electronic)
IS  - 0960-9776 (Linking)
VI  - 19
IP  - 5
DP  - 2010 Oct
TI  - Hormonal and metabolic modulation through nutrition: towards a primary prevention
      of breast cancer.
PG  - 322-32
LID - 10.1016/j.breast.2010.05.005 [doi]
AB  - Breast cancer (BC) is a polygenic and multifactorial disease for which estrogens 
      have been recognized as the main risk factor, and for which lifestyle plays a key
      role. Previous epidemiologic cancer research performed in Uruguayan population
      delimited its dietary and anthropometric profiles. Recognizing the difficulty for
      universalizing a nutritional basis for prevention due to different eating
      patterns among regions and countries, we summarize the existent knowledge linking
      nutrition, estrogens, metabolism and BC. As an attempt towards primary prevention
      of BC, we present recommendations mainly based on country-specific research
      findings and modifiable putative risk and protective factors, proposing to modify
      the intake of meats and other fatty foods--especially sources of Omega-6 and
      Omega-3 fatty acids--adding olive oil, selected vegetables, citrus fruits and
      working towards adequate body fat/muscle proportions. From a medical and ethical 
      viewpoint, it is justified to recommend certain nutritional changes to women,
      because no adverse side effects are expected to occur.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Ronco, Alvaro L
AU  - Ronco AL
AD  - Depto. de Epidemiologia, Facultad de Medicina, IUCLAEH, Prado and Salt Lake P.16,
      Maldonado, Uruguay. alronco@gmail.com
FAU - De Stefani, Eduardo
AU  - De Stefani E
FAU - Stoll, Mario
AU  - Stoll M
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100609
PL  - Netherlands
TA  - Breast
JT  - Breast (Edinburgh, Scotland)
JID - 9213011
RN  - 0 (Dietary Fats)
RN  - 0 (Estrogens)
RN  - 0 (Phytoestrogens)
RN  - 1406-16-2 (Vitamin D)
RN  - 36-88-4 (Carotenoids)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Anthropometry
MH  - Breast Neoplasms/epidemiology/*metabolism/*prevention & control
MH  - Carotenoids/metabolism
MH  - Cholesterol/metabolism
MH  - Diet
MH  - Dietary Fats/adverse effects
MH  - Estrogens/adverse effects/*metabolism
MH  - *Feeding Behavior
MH  - Female
MH  - *Food
MH  - Humans
MH  - Meat
MH  - Phytoestrogens/metabolism
MH  - Primary Prevention
MH  - Risk Factors
MH  - Uruguay/epidemiology
MH  - Vegetables
MH  - Vitamin D/metabolism
EDAT- 2010/06/15 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/06/15 06:00
PHST- 2010/02/22 00:00 [received]
PHST- 2010/05/11 00:00 [revised]
PHST- 2010/05/12 00:00 [accepted]
PHST- 2010/06/15 06:00 [entrez]
PHST- 2010/06/15 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - S0960-9776(10)00137-2 [pii]
AID - 10.1016/j.breast.2010.05.005 [doi]
PST - ppublish
SO  - Breast. 2010 Oct;19(5):322-32. doi: 10.1016/j.breast.2010.05.005. Epub 2010 Jun
      9.


PMID- 20542599
OWN - NLM
STAT- MEDLINE
DCOM- 20110322
LR  - 20220331
IS  - 0210-5691 (Print)
IS  - 0210-5691 (Linking)
VI  - 34
IP  - 8
DP  - 2010 Nov
TI  - [Ethics of the cardiopulmonary resuscitation decisions].
PG  - 534-49
LID - 10.1016/j.medin.2010.04.013 [doi]
AB  - Cardiopulmonary Resuscitation (CPR) must be attempted if indicated, not done if
      it is not indicated or if the patient does not accept or has previously rejected 
      it and withdrawn it if it is ineffective. If CPR is considered futile, a
      Do-Not-Resuscitate Order (DNR) will be recorded. This should be made known to all
      physicians and nurses involved in patient care. It may be appropriate to limit
      life-sustaining-treatments for patients with severe anoxic encephalopathy, if the
      possibility of clinical evolution to brain death is ruled out. After CPR it is
      necessary to inform and support families and then review the process in order to 
      make future improvements. After limitation of vital support, certain type of
      non-heart-beating-organ donation can be proposed. In order to acquire CPR skills,
      it is necessary to practice with simulators and, sometimes, with recently
      deceased, always with the consent of the family. Research on CPR is essential and
      must be conducted according to ethical rules and legal frameworks.
CI  - Copyright (c) 2010 Elsevier Espana, S.L. y SEMICYUC. All rights reserved.
FAU - Monzon, J L
AU  - Monzon JL
AD  - Unidad de Medicina Intensiva, Hospital San Pedro, Logrono, Espana.
      jlmonzn@gmail.com
FAU - Saralegui, I
AU  - Saralegui I
FAU - Molina, R
AU  - Molina R
FAU - Abizanda, R
AU  - Abizanda R
FAU - Cruz Martin, M
AU  - Cruz Martin M
FAU - Cabre, L
AU  - Cabre L
FAU - Martinez, K
AU  - Martinez K
FAU - Arias, J J
AU  - Arias JJ
FAU - Lopez, V
AU  - Lopez V
FAU - Gracia, R M
AU  - Gracia RM
FAU - Rodriguez, A
AU  - Rodriguez A
FAU - Masnou, N
AU  - Masnou N
CN  - Grupo de Bioetica de la SEMICYUC
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Etica de las decisiones en resucitacion cardiopulmonar.
DEP - 20100609
PL  - Spain
TA  - Med Intensiva
JT  - Medicina intensiva
JID - 9207689
SB  - IM
MH  - Aftercare
MH  - Cardiopulmonary Resuscitation/education/*ethics
MH  - Decision Making/ethics
MH  - Euthanasia, Passive
MH  - Family
MH  - Forms and Records Control
MH  - Humans
MH  - Hypoxia, Brain/therapy
MH  - Medical Futility
MH  - Medical Records
MH  - Professional-Family Relations
MH  - Research
MH  - Resuscitation Orders
MH  - Spain
MH  - Third-Party Consent
MH  - Tissue and Organ Harvesting/ethics/legislation & jurisprudence
MH  - Withholding Treatment
EDAT- 2010/06/15 06:00
MHDA- 2011/03/23 06:00
CRDT- 2010/06/15 06:00
PHST- 2010/02/25 00:00 [received]
PHST- 2010/04/22 00:00 [revised]
PHST- 2010/04/23 00:00 [accepted]
PHST- 2010/06/15 06:00 [entrez]
PHST- 2010/06/15 06:00 [pubmed]
PHST- 2011/03/23 06:00 [medline]
AID - S0210-5691(10)00119-1 [pii]
AID - 10.1016/j.medin.2010.04.013 [doi]
PST - ppublish
SO  - Med Intensiva. 2010 Nov;34(8):534-49. doi: 10.1016/j.medin.2010.04.013. Epub 2010
      Jun 9.


PMID- 20542528
OWN - NLM
STAT- MEDLINE
DCOM- 20100806
LR  - 20151119
IS  - 1532-7361 (Electronic)
IS  - 0039-6060 (Linking)
VI  - 148
IP  - 2
DP  - 2010 Aug
TI  - Self-reported attitudes and behaviors of general surgery residents about ethical 
      academic practices in test taking.
PG  - 178-80
LID - 10.1016/j.surg.2010.04.016 [doi]
AB  - BACKGROUND: A correlation exists between people who engage in academic dishonesty
      as students and unethical behaviors later as professionals. Academic dishonesty
      has been assessed among medical students, but not among general surgery
      residents. We sought to describe the attitudes of general surgery residents with 
      regard to ethical practices in test taking. METHODS: A survey with 4 scenarios
      describing activities related to examination taking that may or may not be
      considered unethical was administered. Participants were asked about
      participation in the activities-either personally or any knowledge of others-and 
      whether the activities were unethical. RESULTS: Fifty-seven of 62 residents (92%)
      participated. For each scenario, >70% indicated that neither they nor anyone else
      they knew had participated in the activities. Behaviors deemed unethical included
      memorizing or using memorized questions to prepare for future tests (52%),
      selling questions for financial gain (90%), and purchasing previously used
      questions (57%). No difference in attitudes was seen among incoming interns,
      junior-level (postgraduate year [PGY]1-3), or senior-level (PGY4-6) residents.
      CONCLUSION: Overall, general surgery residents indicated that they had not
      participated in activities they felt to be unethical. Defining what is unethical 
      was less clear. This represents an area for further education.
CI  - Copyright 2010 Mosby, Inc. All rights reserved.
FAU - Grignol, Valerie P
AU  - Grignol VP
AD  - Department of Surgery, Wright State University Boonshoft School of Medicine,
      Dayton, OH 45409, USA.
FAU - Gans, Alyssa
AU  - Gans A
FAU - Booth, Branyan A
AU  - Booth BA
FAU - Markert, Ronald
AU  - Markert R
FAU - Termuhlen, Paula M
AU  - Termuhlen PM
LA  - eng
PT  - Journal Article
DEP - 20100609
PL  - United States
TA  - Surgery
JT  - Surgery
JID - 0417347
SB  - IM
MH  - Attitude of Health Personnel
MH  - Behavior
MH  - Certification/ethics
MH  - Educational Measurement
MH  - *Ethics, Medical
MH  - General Surgery/education/*ethics
MH  - Humans
MH  - Internship and Residency/*ethics
MH  - Specialty Boards/ethics
MH  - Surveys and Questionnaires
MH  - United States
EDAT- 2010/06/15 06:00
MHDA- 2010/08/07 06:00
CRDT- 2010/06/15 06:00
PHST- 2010/01/06 00:00 [received]
PHST- 2010/04/16 00:00 [accepted]
PHST- 2010/06/15 06:00 [entrez]
PHST- 2010/06/15 06:00 [pubmed]
PHST- 2010/08/07 06:00 [medline]
AID - S0039-6060(10)00211-4 [pii]
AID - 10.1016/j.surg.2010.04.016 [doi]
PST - ppublish
SO  - Surgery. 2010 Aug;148(2):178-80. doi: 10.1016/j.surg.2010.04.016. Epub 2010 Jun
      9.


PMID- 20542343
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20220317
IS  - 1879-0887 (Electronic)
IS  - 0167-8140 (Linking)
VI  - 96
IP  - 1
DP  - 2010 Jul
TI  - Trend analysis of radiation therapy incidents over seven years.
PG  - 139-44
LID - 10.1016/j.radonc.2010.05.002 [doi]
AB  - PURPOSE: To examine incident rates in external beam radiation therapy (RT) as
      significant changes in technology were introduced. MATERIALS AND METHODS: From
      2001 to 2007, several technological and practice enhancements were made. All
      treatment incident reports, including near misses (from 2004), were classified,
      under a research ethics board approval, according to type (prescription or
      geometry), cause (location, documentation, non-compliance, laterality, prescribed
      change, human error, planning/dosimetry, software/hardware malfunction, and
      accessory), and clinical impact (none, minor, moderate, and severe). Trend
      analysis was performed retrospectively. RESULTS: One thousand and sixty three
      reports were analyzed. The average incident rate per 100 RT course was 1.7+/-0.4;
      excluding near misses, this rate fell to 1.4+/-0.3. Both rates showed a downward 
      trend. The occurrence of events due to treatment accessories (0.75-0.28),
      prescribed changes to treatment parameters (0.17-0.03), and location (0.41-0.17) 
      have decreased, while documentation-related incidents have risen (0.03-0.37). The
      proportion of incidents is highest at the planning and treatment stages.
      CONCLUSION: Our analysis has shown that while technological and process
      enhancements can reduce certain error pathways, others can be created. Trends in 
      incident rates have been assessed, indicating robustness of our practice in view 
      of these changes.
CI  - Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Bissonnette, Jean-Pierre
AU  - Bissonnette JP
AD  - Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada.
      jean-pierre.bissonnette@rmp.uhn.on.ca
FAU - Medlam, Gaylene
AU  - Medlam G
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20100611
PL  - Ireland
TA  - Radiother Oncol
JT  - Radiotherapy and oncology : journal of the European Society for Therapeutic
      Radiology and Oncology
JID - 8407192
SB  - IM
MH  - Canada
MH  - Databases, Factual
MH  - Humans
MH  - Medical Errors/*statistics & numerical data
MH  - Quality Control
MH  - Radiation Injuries/*epidemiology/prevention & control
MH  - Radiation Oncology/methods/*trends
MH  - Radiotherapy Dosage
MH  - Safety Management
MH  - Time Factors
EDAT- 2010/06/15 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/06/15 06:00
PHST- 2010/03/17 00:00 [received]
PHST- 2010/05/12 00:00 [revised]
PHST- 2010/05/14 00:00 [accepted]
PHST- 2010/06/15 06:00 [entrez]
PHST- 2010/06/15 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S0167-8140(10)00306-3 [pii]
AID - 10.1016/j.radonc.2010.05.002 [doi]
PST - ppublish
SO  - Radiother Oncol. 2010 Jul;96(1):139-44. doi: 10.1016/j.radonc.2010.05.002. Epub
      2010 Jun 11.


PMID- 20541853
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20161018
IS  - 1768-3122 (Electronic)
IS  - 0248-8663 (Linking)
VI  - 32
IP  - 3
DP  - 2011 Mar
TI  - [Key points of the follow-up plan in the care of Alzheimer's disease patients].
PG  - 154-8
LID - 10.1016/j.revmed.2010.03.455 [doi]
AB  - The following article presents the main points of the follow-up plan of
      Alzheimer's disease (AD) and related syndromes patients. The general objective of
      this follow-up plan is to improve the quality of live of these subjects and their
      family. The key points are assessments of cognitive decline, functional decline
      and complications such as behavioural and psychological symptoms of dementia
      (BPSD), malnutrition and gait and balance disorders. In clinical practice,
      different tools are available, but frequency of evaluation is not consensual.
      However, the aim of this follow-up is to detect, prevent and treat complications 
      and to improve the use of residual functional abilities in basic activities of
      daily living. The physician also needs to detect and prevent caregiver's
      exhaustion and to consider the ethical issues raised by the disease. The care
      plan is based on non pharmacological and pharmacological measures. The non
      pharmacological approach must be implemented first. The place of anti-dementia
      drugs is considered. Lastly, this follow-up plan aims to limit iterative
      admissions to emergency room and to increase the access to geriatric units.
      Communication and collaboration between specialist, family practitioner and
      caregivers are needed in order to reach the objective of quality of life
      improvement in AD patients.
CI  - Copyright (c) 2010 Societe nationale francaise de medecine interne (SNFMI).
      Published by Elsevier SAS. All rights reserved.
FAU - Hein, C
AU  - Hein C
AD  - Service de medecine interne et gerontologie clinique, CHU Purpan Casselardit, 170
      avenue de Casselardit, Toulouse, France. hein.c@chu-toulouse.fr
FAU - Sourdet, S
AU  - Sourdet S
FAU - Piau, A
AU  - Piau A
FAU - Villars, H
AU  - Villars H
FAU - Nourhashemi, F
AU  - Nourhashemi F
FAU - Vellas, B
AU  - Vellas B
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Enjeux et moyens du suivi des malades souffrant de la maladie d'Alzheimer.
DEP - 20100611
PL  - France
TA  - Rev Med Interne
JT  - La Revue de medecine interne
JID - 8101383
SB  - IM
MH  - Alzheimer Disease/complications/*therapy
MH  - Follow-Up Studies
MH  - Humans
EDAT- 2010/06/15 06:00
MHDA- 2011/06/29 06:00
CRDT- 2010/06/15 06:00
PHST- 2009/12/11 00:00 [received]
PHST- 2010/02/10 00:00 [revised]
PHST- 2010/03/03 00:00 [accepted]
PHST- 2010/06/15 06:00 [entrez]
PHST- 2010/06/15 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
AID - S0248-8663(10)00690-9 [pii]
AID - 10.1016/j.revmed.2010.03.455 [doi]
PST - ppublish
SO  - Rev Med Interne. 2011 Mar;32(3):154-8. doi: 10.1016/j.revmed.2010.03.455. Epub
      2010 Jun 11.


PMID- 20541829
OWN - NLM
STAT- MEDLINE
DCOM- 20110819
LR  - 20111117
IS  - 1872-7565 (Electronic)
IS  - 0169-2607 (Linking)
VI  - 102
IP  - 3
DP  - 2011 Jun
TI  - Modeling the glucose regulatory system in extreme preterm infants.
PG  - 253-66
LID - 10.1016/j.cmpb.2010.05.006 [doi]
AB  - BACKGROUND: Premature infants represent a significant proportion of the neonatal 
      intensive care population. Blood glucose homeostasis in this group is often
      disturbed by immaturity of endogenous regulatory systems and the stress of their 
      condition. Hypo- and hyperglycemia are frequently reported in very low birth
      weight infants, and more mature infants often experience low levels of glycemia. 
      A model capturing the unique fundamental dynamics of the neonatal glucose
      regulatory system could be used to develop better blood glucose control methods. 
      METHODS: A metabolic system model is adapted from adult critical care to the
      unique physiological case of the neonate. Integral-based fitting methods were
      used to identify time-varying insulin sensitivity and non-insulin mediated
      glucose uptake profiles. The clinically important predictive ability of the model
      was assessed by assuming insulin sensitivity was constant over prediction
      intervals of 1, 2 and 4h forward and comparing model-simulated versus actual
      clinical glucose values for all recorded interventions. The clinical data
      included 1091 glucose measurements over 3567 total patient hours, along with all 
      associated insulin and nutritional infusion data, for N=25 total cases. Ethics
      approval was obtained from the Upper South A Regional Ethics Committee for this
      study. RESULTS: The identified model had a median absolute percentage error of
      2.4% [IQR: 0.9-4.8%] between model-fitted and clinical glucose values. Median
      absolute prediction errors at 1-, 2- and 4-h intervals were 5.2% [IQR:
      2.5-10.3%], 9.4% [IQR: 4.5-18.4%] and 13.6% [IQR: 6.3-27.6%] respectively.
      CONCLUSIONS: The model accurately captures and predicts the fundamental dynamic
      behaviors of the neonatal metabolism well enough for effective clinical decision 
      support in glycemic control. The adaptation from adult to a neonatal case is
      based on the data from the literature. Low prediction errors and very low fitting
      errors indicate that the fundamental dynamics of glucose metabolism in both
      premature neonates and critical care adults can be described by similar
      mathematical models.
CI  - Copyright (c) 2010. Published by Elsevier Ireland Ltd.
FAU - Le Compte, Aaron
AU  - Le Compte A
AD  - Department of Mechanical Engineering, University of Canterbury, New Zealand.
FAU - Chase, J Geoffrey
AU  - Chase JG
FAU - Russell, Glynn
AU  - Russell G
FAU - Lynn, Adrienne
AU  - Lynn A
FAU - Hann, Chris
AU  - Hann C
FAU - Shaw, Geoffrey
AU  - Shaw G
FAU - Wong, Xing-Wei
AU  - Wong XW
FAU - Blakemore, Amy
AU  - Blakemore A
FAU - Lin, Jessica
AU  - Lin J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100612
PL  - Ireland
TA  - Comput Methods Programs Biomed
JT  - Computer methods and programs in biomedicine
JID - 8506513
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
SB  - IM
MH  - Blood Glucose/*metabolism
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Hyperglycemia/metabolism
MH  - Infant, Newborn
MH  - Infant, Premature/*blood/*metabolism
MH  - Insulin/blood
MH  - Male
MH  - Models, Biological
MH  - Retrospective Studies
EDAT- 2010/06/15 06:00
MHDA- 2011/08/20 06:00
CRDT- 2010/06/15 06:00
PHST- 2009/06/07 00:00 [received]
PHST- 2010/04/23 00:00 [revised]
PHST- 2010/05/18 00:00 [accepted]
PHST- 2010/06/15 06:00 [entrez]
PHST- 2010/06/15 06:00 [pubmed]
PHST- 2011/08/20 06:00 [medline]
AID - S0169-2607(10)00121-5 [pii]
AID - 10.1016/j.cmpb.2010.05.006 [doi]
PST - ppublish
SO  - Comput Methods Programs Biomed. 2011 Jun;102(3):253-66. doi:
      10.1016/j.cmpb.2010.05.006. Epub 2010 Jun 12.


PMID- 20541691
OWN - NLM
STAT- MEDLINE
DCOM- 20100928
LR  - 20100614
IS  - 1879-1131 (Electronic)
IS  - 0738-081X (Linking)
VI  - 28
IP  - 3
DP  - 2010 May-Jun
TI  - The challenge of drug-rechallenge: Facts and controversies.
PG  - 349-53
LID - 10.1016/j.clindermatol.2009.06.019 [doi]
AB  - The accurate identification of the culprit drug inducing a patient's cutaneous
      adverse drug reaction is important to avoid future adverse reactions and to
      provide safe alternative drugs. The assessment has to rely on the clinical signs,
      the time course, and response to treatment. Sometimes, additional diagnostic
      procedures are also needed. If diagnostic procedures such as in vivo skin testing
      and in vitro laboratory tests do not lead to conclusive results, confirmation of 
      a presumptive diagnosis by a rechallenge test is often the only reliable way to
      establish a diagnosis. This procedure should be undertaken only with great
      caution and a compelling need, because a rechallenge test might cause severe or
      even fatal reactions. Contraindications and ethical considerations should be
      taken into account and an individual risk-benefit calculation must be performed
      in every case.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Davidovici, Batya B
AU  - Davidovici BB
AD  - The Dermatology Unit, Kaplan Medical Center, Rechovot 76100, Israel.
      bdavidovici@yahoo.com
FAU - Wolf, Ronni
AU  - Wolf R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Dermatol
JT  - Clinics in dermatology
JID - 8406412
RN  - 0 (Prescription Drugs)
SB  - IM
MH  - Drug Eruptions/*diagnosis
MH  - Humans
MH  - Predictive Value of Tests
MH  - Prescription Drugs/*adverse effects
MH  - Risk Assessment
EDAT- 2010/06/15 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/06/15 06:00
PHST- 2010/06/15 06:00 [entrez]
PHST- 2010/06/15 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - S0738-081X(09)00152-7 [pii]
AID - 10.1016/j.clindermatol.2009.06.019 [doi]
PST - ppublish
SO  - Clin Dermatol. 2010 May-Jun;28(3):349-53. doi:
      10.1016/j.clindermatol.2009.06.019.


PMID- 20541396
OWN - NLM
STAT- MEDLINE
DCOM- 20101129
LR  - 20131121
IS  - 1879-0852 (Electronic)
IS  - 0959-8049 (Linking)
VI  - 46
IP  - 11
DP  - 2010 Jul
TI  - MGMT expression levels predict disease stabilisation, progression-free and
      overall survival in patients with advanced melanomas treated with DTIC.
PG  - 2127-33
LID - 10.1016/j.ejca.2010.04.023 [doi]
AB  - Metastatic melanoma responds poorly to systemic treatment. We report the results 
      of a prospective single institution study evaluating O(6)-methylguanine-DNA
      methyltransferase (MGMT) status as a potential predictive and/or prognostic
      marker among patients treated with dacarbazine (DTIC) 800-1000 mg/m(2)
      monotherapy administered as a 3-weekly schedule for advanced malignant melanomas.
      The study was approved by the Regional Ethical Committee. Surgical biopsies from 
      metastatic or loco-regional deposits obtained prior to DTIC treatment were
      snap-frozen immediately upon removal and stored in liquid nitrogen up to
      processing. Median time from enrolment to end of follow-up was 67 months. MGMT
      expression levels evaluated by qRT-PCR correlated significantly to DTIC benefit
      (CR/PR/SD; p=0.005), time to progression (TTP) (p=0.005) and overall survival
      (OS) (p=0.003). MGMT expression also correlated to Breslow thickness in the
      primary tumour (p=0.014). While MGMT promoter hypermethylation correlated to MGMT
      expression, MGMT promoter hypermethylation did not correlate to treatment
      benefit, TTP or OS, suggesting that other factors may be critical in determining 
      MGMT expression levels in melanomas. In a Cox proportional regression analysis,
      serum lactate dehydrogenase (LDH, p<0.001), MGMT expression (p=0.022) and
      p16(INK4a) expression (p=0.037) independently predicted OS, while TTP correlated 
      to DTIC benefit after 6 weeks only (p=0.001). Our data reveal MGMT expression
      levels to be associated with disease stabilisation and prognosis in patients
      receiving DTIC monotherapy for advanced melanoma. The role of MGMT expression as 
      a predictor to DTIC sensitivity versus a general prognostic factor in advanced
      melanomas warrants further evaluation.
CI  - Copyright 2010 Elsevier Ltd. All rights reserved.
FAU - Busch, Christian
AU  - Busch C
AD  - Section of Oncology, Institute of Medicine, University of Bergen, Norway.
FAU - Geisler, Jurgen
AU  - Geisler J
FAU - Lillehaug, Johan R
AU  - Lillehaug JR
FAU - Lonning, Per Eystein
AU  - Lonning PE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100610
PL  - England
TA  - Eur J Cancer
JT  - European journal of cancer (Oxford, England : 1990)
JID - 9005373
RN  - 0 (Antineoplastic Agents, Alkylating)
RN  - 0 (Tumor Suppressor Proteins)
RN  - 7GR28W0FJI (Dacarbazine)
RN  - EC 2.1.1.- (DNA Modification Methylases)
RN  - EC 2.1.1.63 (MGMT protein, human)
RN  - EC 6.5.1.- (DNA Repair Enzymes)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antineoplastic Agents, Alkylating/*therapeutic use
MH  - DNA Methylation
MH  - DNA Modification Methylases/*metabolism
MH  - DNA Repair Enzymes/*metabolism
MH  - Dacarbazine/*therapeutic use
MH  - Disease-Free Survival
MH  - Eye Neoplasms/*drug therapy/metabolism/mortality
MH  - Female
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Melanoma/*drug therapy/metabolism/mortality
MH  - Middle Aged
MH  - Neoplasm Metastasis
MH  - Neoplasm Recurrence, Local/metabolism/mortality
MH  - Prognosis
MH  - Prospective Studies
MH  - Skin Neoplasms/*drug therapy/metabolism/mortality
MH  - Tumor Suppressor Proteins/*metabolism
EDAT- 2010/06/15 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/06/15 06:00
PHST- 2009/12/18 00:00 [received]
PHST- 2010/04/23 00:00 [revised]
PHST- 2010/04/28 00:00 [accepted]
PHST- 2010/06/15 06:00 [entrez]
PHST- 2010/06/15 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S0959-8049(10)00364-3 [pii]
AID - 10.1016/j.ejca.2010.04.023 [doi]
PST - ppublish
SO  - Eur J Cancer. 2010 Jul;46(11):2127-33. doi: 10.1016/j.ejca.2010.04.023. Epub 2010
      Jun 10.


PMID- 20541086
OWN - NLM
STAT- MEDLINE
DCOM- 20101004
LR  - 20220318
IS  - 1460-9576 (Electronic)
IS  - 0968-8080 (Linking)
VI  - 18
IP  - 35
DP  - 2010 May
TI  - On norms and bodies: findings from field research on cosmetic surgery in Rio de
      Janeiro, Brazil.
PG  - 74-83
LID - 10.1016/S0968-8080(10)35519-4 [doi]
AB  - Brazil has the second highest rate of cosmetic surgery worldwide, provided in a
      large number of public and private clinics and hospitals, especially in the
      southeast. This qualitative field research in Rio de Janeiro included participant
      observation and in-depth interviews with 18 women cosmetic surgery patients, 10
      key informants (e.g. psychologists and sociologists) and 12 plastic surgeons.
      Fifteen of the women were either pre- or post-operative; three had not decided
      whether to have surgery. When asked about their motivations and expectations of
      the surgery, the majority of the women said they wanted to be "normal". Most of
      the surgeons said they acted as empathic companions from decision-making through 
      surgery and beyond. Many of the key informants were critical of what was
      happening to medical ethics in relation to cosmetic surgery. With the growth in a
      consumer culture, they saw ethics in medicine becoming more bendable and subject 
      to the "law" of the market. The cult of the body has become a mass phenomenon and
      taken on an important social dimension in a society where norms and images are
      broadcast widely by the media. The trend towards body-modification by cosmetic
      surgery at an early age is increasing dramatically. What demands critical
      thinking and further investigation are the consequences of cosmetic surgery for
      physical and mental health.
CI  - Copyright 2010 Reproductive Health Matters. Published by Elsevier Ltd. All rights
      reserved.
FAU - Dorneles de Andrade, Daniela
AU  - Dorneles de Andrade D
AD  - Institute of Political Science, University of Vienna, Vienna, Austria.
      daniela.dorneles@univie.ac.at
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Reprod Health Matters
JT  - Reproductive health matters
JID - 9420826
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Body Image
MH  - Brazil
MH  - Female
MH  - Health Personnel
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Motivation
MH  - *Research
MH  - *Surgery, Plastic
MH  - Young Adult
EDAT- 2010/06/15 06:00
MHDA- 2010/10/05 06:00
CRDT- 2010/06/15 06:00
PHST- 2010/06/15 06:00 [entrez]
PHST- 2010/06/15 06:00 [pubmed]
PHST- 2010/10/05 06:00 [medline]
AID - S0968-8080(10)35519-4 [pii]
AID - 10.1016/S0968-8080(10)35519-4 [doi]
PST - ppublish
SO  - Reprod Health Matters. 2010 May;18(35):74-83. doi: 10.1016/S0968-8080(10)35519-4.


PMID- 20540803
OWN - NLM
STAT- MEDLINE
DCOM- 20100729
LR  - 20211020
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 11
DP  - 2010 Jun 13
TI  - How informed is consent in vulnerable populations? Experience using a continuous 
      consent process during the MDP301 vaginal microbicide trial in Mwanza, Tanzania.
PG  - 10
LID - 10.1186/1472-6939-11-10 [doi]
AB  - BACKGROUND: HIV prevention trials conducted among disadvantaged vulnerable
      at-risk populations in developing countries present unique ethical dilemmas. A
      key concern in bioethics is the validity of informed consent for trial
      participation obtained from research subjects in such settings. The purpose of
      this study was to investigate the effectiveness of a continuous informed consent 
      process adopted during the MDP301 phase III vaginal microbicide trial in Mwanza, 
      Tanzania. METHODS: A total of 1146 women at increased risk of HIV acquisition
      working as alcohol and food vendors or in bars, restaurants, hotels and
      guesthouses have been recruited into the MDP301 phase III efficacy and safety
      trial in Mwanza. During preparations for the trial, participatory community
      research methods were used to develop a locally-appropriate pictorial flipchart
      in order to convey key messages about the trial to potential participants.
      Pre-recorded audio tapes were also developed to facilitate understanding and
      compliance with gel-use instructions. A comprehension checklist is administered
      by clinical staff to all participants at screening, enrolment, 12, 24, 40 and 50 
      week follow-up visits during the trial. To investigate women's perceptions and
      experiences of the trial, including how well participants internalize and retain 
      key messages provided through a continuous informed consent process, a random
      sub-sample of 102 women were invited to participate in in-depth interviews (IDIs)
      conducted immediately after their 4, 24 and 52 week follow-up visits. RESULTS: 99
      women completed interviews at 4-weeks, 83 at 24-weeks, and 74 at 52 weeks (a
      total of 256 interviews). In all interviews there was evidence of good
      comprehension and retention of key trial messages including that the gel is not
      currently know to be effective against HIV; that this is the key reason for
      conducting the trial; and that women should stop using gel in the event of
      pregnancy. CONCLUSIONS: Providing information to trial participants in a
      focussed, locally-appropriate manner, using methods developed in consultation
      with the community, and within a continuous informed-consent framework resulted
      in high levels of comprehension and message retention in this setting. This
      approach may represent a model for researchers conducting HIV prevention trials
      among other vulnerable populations in resource-poor settings. TRIAL REGISTRATION:
      Current Controlled Trials ISRCTN64716212.
FAU - Vallely, Andrew
AU  - Vallely A
AD  - London School of Hygiene & Tropical Medicine, London, UK. a.vallely@uq.edu.au
FAU - Lees, Shelley
AU  - Lees S
FAU - Shagi, Charles
AU  - Shagi C
FAU - Kasindi, Stella
AU  - Kasindi S
FAU - Soteli, Selephina
AU  - Soteli S
FAU - Kavit, Natujwa
AU  - Kavit N
FAU - Vallely, Lisa
AU  - Vallely L
FAU - McCormack, Sheena
AU  - McCormack S
FAU - Pool, Robert
AU  - Pool R
FAU - Hayes, Richard J
AU  - Hayes RJ
CN  - Microbicides Development Programme (MDP)
LA  - eng
SI  - ISRCTN/ISRCTN64716212
GR  - G0100137/MRC_/Medical Research Council/United Kingdom
GR  - G0501954/MRC_/Medical Research Council/United Kingdom
GR  - G0700837/MRC_/Medical Research Council/United Kingdom
PT  - Clinical Trial, Phase III
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20100613
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
RN  - 0 (Anti-HIV Agents)
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Gels)
RN  - 0 (Mesylates)
RN  - 9017-33-8 (naphthalenesulfonic acid, polymer with formaldehyde)
SB  - IM
MH  - Administration, Intravaginal
MH  - Adolescent
MH  - Adult
MH  - Anti-HIV Agents/*administration & dosage
MH  - Anti-Infective Agents/administration & dosage
MH  - *Comprehension
MH  - Ethics, Research
MH  - Female
MH  - Gels
MH  - HIV Infections/*prevention & control
MH  - Humans
MH  - Informed Consent/*ethics
MH  - *Mental Recall
MH  - Mesylates/administration & dosage/*therapeutic use
MH  - Middle Aged
MH  - Surveys and Questionnaires
MH  - Tanzania
MH  - Therapeutic Human Experimentation/*ethics
MH  - Time Factors
MH  - Treatment Outcome
MH  - *Vulnerable Populations
MH  - Young Adult
PMC - PMC2893460
EDAT- 2010/06/15 06:00
MHDA- 2010/07/30 06:00
CRDT- 2010/06/15 06:00
PHST- 2009/08/29 00:00 [received]
PHST- 2010/06/13 00:00 [accepted]
PHST- 2010/06/15 06:00 [entrez]
PHST- 2010/06/15 06:00 [pubmed]
PHST- 2010/07/30 06:00 [medline]
AID - 1472-6939-11-10 [pii]
AID - 10.1186/1472-6939-11-10 [doi]
PST - epublish
SO  - BMC Med Ethics. 2010 Jun 13;11:10. doi: 10.1186/1472-6939-11-10.


PMID- 20540766
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1478-7547 (Electronic)
IS  - 1478-7547 (Linking)
VI  - 8
IP  - 1
DP  - 2010 Jun 11
TI  - Cost-effectiveness analysis of clinical specialist outreach as compared to
      referral system in Ethiopia: an economic evaluation.
PG  - 13
LID - 10.1186/1478-7547-8-13 [doi]
AB  - BACKGROUND: In countries with scarce specialized Human resource for health,
      patients are usually referred. The other alternative has been mobilizing
      specialists, clinical specialist outreach. This study examines whether clinical
      specialist outreach is a cost effective way of using scarce health expertise to
      provide specialist care as compared to provision of such services through
      referral system in Ethiopia. METHODS: A cross-sectional study on four purposively
      selected regional hospitals and three central referral hospitals was conducted
      from Feb 4-24, 2009. The perspective of analysis was societal covering analytic
      horizon and time frame from 1 April 2007 to 31 Dec 2008. Data were collected
      using interview of specialists, project focal persons, patients and review of
      records. To ensure the propriety standards of evaluation, Ethical clearance was
      obtained from Jimma University. RESULTS: It was found that 532 patients were
      operated at outreach hospitals in 125 specialist days. The unit cost of surgical 
      procedures was found to be ETB 4,499.43. On the other hand, if the 125 clinical
      specialist days were spent to serve patients referred from zonal and regional
      hospitals at central referral hospitals, 438 patients could have been served. And
      the unit cost of surgical procedures through referral would have been ETB
      6,523.27 per patient. This makes clinical specialist outreach 1.45 times more
      cost effective way of using scarce clinical specialists' time as compared to
      referral system. CONCLUSION: Clinical specialist outreach is a cost effective and
      cost saving way of spending clinical specialists' time as compared to provision
      of similar services through referral system.
FAU - Kifle, Yibeltal A
AU  - Kifle YA
AD  - College of Public Health and Medical Sciences, Jimma University, Jimma, Ethiopia.
FAU - Nigatu, Tilahun H
AU  - Nigatu TH
AD  - Department of Monitoring, Evaluation and Research, African Medical and Research
      Foundation (AMREF), Addis Ababa, Ethiopia.
LA  - eng
PT  - Journal Article
DEP - 20100611
PL  - England
TA  - Cost Eff Resour Alloc
JT  - Cost effectiveness and resource allocation : C/E
JID - 101170476
PMC - PMC2892431
EDAT- 2010/06/15 06:00
MHDA- 2010/06/15 06:01
CRDT- 2010/06/15 06:00
PHST- 2009/12/13 00:00 [received]
PHST- 2010/06/11 00:00 [accepted]
PHST- 2010/06/15 06:00 [entrez]
PHST- 2010/06/15 06:00 [pubmed]
PHST- 2010/06/15 06:01 [medline]
AID - 1478-7547-8-13 [pii]
AID - 10.1186/1478-7547-8-13 [doi]
PST - epublish
SO  - Cost Eff Resour Alloc. 2010 Jun 11;8(1):13. doi: 10.1186/1478-7547-8-13.


PMID- 20540757
OWN - NLM
STAT- MEDLINE
DCOM- 20100929
LR  - 20211020
IS  - 1472-6920 (Electronic)
IS  - 1472-6920 (Linking)
VI  - 10
DP  - 2010 Jun 11
TI  - Planning training seminars in palliative care: a cross-sectional survey on the
      preferences of general practitioners and nurses in Austria.
PG  - 43
LID - 10.1186/1472-6920-10-43 [doi]
AB  - BACKGROUND: Training in palliative care is frequently requested by health care
      professionals. However, little is known in detail about the subject matters and
      the educational preferences of physicians and staff or assistant nurses in this
      field. METHODS: All 897 registered GPs and all 933 registered home care nurses in
      the district of Steiermark/Austria were sent postal questionnaires. RESULTS:
      Results from 546 (30%) respondents revealed that GPs prefer evening courses and
      weekend seminars, whereas staff and assistant nurses prefer one-day courses.
      Multidisciplinary sessions are preferred by almost 80% of all professional
      groups. GPs preferred multi disciplinary groups most frequently when addressing
      psychosocial needs (88.8%) and ethical questions (85.8%). Staff and assistant
      nurses preferred multidisciplinary groups most frequently in the area of pain
      management (88%) and opted for multi disciplinary learning to a significantly
      higher extent than GPs (69%; p < 0.01). Those topics were ranked first which are 
      not only deepening, but supplementing the professional training. On average, GPs 
      were willing to spend a maximum amount of euro 400 per year for training seminars
      in palliative care, whereas nurses would spend approximately euro 190 for such
      classes.The results provide a detailed analysis of the preferences of GPs and
      nurses and offer guidance for the organisation of training seminars in palliative
      care. CONCLUSIONS: Medical and nursing education programs often pursue separate
      paths. Yet our findings indicate that in palliative care multidisciplinary
      training seminars are favoured by both, doctors and nurses. Also, both groups
      prefer topics that are not only deepening, but supplementing their professional
      knowledge.
FAU - Becker, Gerhild
AU  - Becker G
AD  - Department of Internal Medicine II, University Medical Center Freiburg, Freiburg,
      Germany. gerhild.becker@uniklinik-freiburg.de
FAU - Momm, Felix
AU  - Momm F
FAU - Deibert, Peter
AU  - Deibert P
FAU - Xander, Carola
AU  - Xander C
FAU - Gigl, Annemarie
AU  - Gigl A
FAU - Wagner, Brigitte
AU  - Wagner B
FAU - Baumgartner, Johann
AU  - Baumgartner J
LA  - eng
PT  - Journal Article
DEP - 20100611
PL  - England
TA  - BMC Med Educ
JT  - BMC medical education
JID - 101088679
SB  - IM
MH  - Adult
MH  - Aged
MH  - Austria
MH  - Cross-Sectional Studies
MH  - *Education, Nursing
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Palliative Care
MH  - Physicians, Family/*education
MH  - *Program Development
PMC - PMC2893516
EDAT- 2010/06/15 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/06/15 06:00
PHST- 2009/08/27 00:00 [received]
PHST- 2010/06/11 00:00 [accepted]
PHST- 2010/06/15 06:00 [entrez]
PHST- 2010/06/15 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - 1472-6920-10-43 [pii]
AID - 10.1186/1472-6920-10-43 [doi]
PST - epublish
SO  - BMC Med Educ. 2010 Jun 11;10:43. doi: 10.1186/1472-6920-10-43.


PMID- 20540744
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1755-7682 (Electronic)
IS  - 1755-7682 (Linking)
VI  - 3
DP  - 2010 Jun 11
TI  - Bioethics in biomedicine in the context of a global higher education area.
PG  - 10
LID - 10.1186/1755-7682-3-10 [doi]
AB  - The University is tasked with drawing together, transmitting and maintaining
      knowledge, while creating an area where the ethical "sense" required for working 
      in the field of Biology and Biomedicine can be provided. Although scientific
      knowledge is present on an overwhelming scale in nature and, therefore, its
      discovery is unceasing, this does not mean that, as a human being, the researcher
      has no limitations. It is Bioethics that sets this limit. The successful
      spreading of knowledge, therefore, which is proclaimed with the creation of a
      Global Higher Education Area, should also pursue the establishment of the
      bioethical principles necessary for the credibility of science and its progress
      so that the society that it promotes and sustains becomes a reality.
FAU - Liras, Antonio
AU  - Liras A
AD  - Department of Physiology, School of Biological Sciences, Complutense University
      of Madrid, Spain. aliras@hotmail.com.
FAU - Arenas, Alicia
AU  - Arenas A
LA  - eng
PT  - Journal Article
DEP - 20100611
PL  - England
TA  - Int Arch Med
JT  - International archives of medicine
JID - 101317943
PMC - PMC2893169
EDAT- 2010/06/15 06:00
MHDA- 2010/06/15 06:01
CRDT- 2010/06/15 06:00
PHST- 2010/02/26 00:00 [received]
PHST- 2010/06/11 00:00 [accepted]
PHST- 2010/06/15 06:00 [entrez]
PHST- 2010/06/15 06:00 [pubmed]
PHST- 2010/06/15 06:01 [medline]
AID - 1755-7682-3-10 [pii]
AID - 10.1186/1755-7682-3-10 [doi]
PST - epublish
SO  - Int Arch Med. 2010 Jun 11;3:10. doi: 10.1186/1755-7682-3-10.


PMID- 20540463
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20191210
IS  - 0022-0124 (Print)
IS  - 0022-0124 (Linking)
VI  - 42
IP  - 1
DP  - 2011 Jan
TI  - Empowering nurses to participate in ethical decision-making at the bedside.
PG  - 19-24; quiz 25-6
LID - 10.3928/00220124-20100601-03 [doi]
AB  - Nurses at the bedside have widely varied educational backgrounds. Most bedside
      nurses have insufficient knowledge in the area of ethical decision-making to feel
      confident in their ability to participate in ethical decision-making along with
      the health care team. Continuing education programs for staff nurses should focus
      on ethical decision-making to empower bedside nurses to participate. The effect
      of a successful continuing education program in ethics could lead to improved
      relationships among health care professionals, improved communication with
      patients and families, and reduced stress-related burnout caused by ethical
      dilemmas. This article describes a successful continuing education program
      designed to improve knowledge of ethics and confidence in ethical decision-making
      that can be adapted for any nursing specialty.
CI  - Copyright 2011, SLACK Incorporated.
FAU - Bicking, Cara
AU  - Bicking C
AD  - Penn State University School of Nursing, Hershey, PA 17033, USA.
      cbicking@hmc.psu.edu
LA  - eng
PT  - Journal Article
DEP - 20100608
PL  - United States
TA  - J Contin Educ Nurs
JT  - Journal of continuing education in nursing
JID - 0262321
MH  - Data Collection
MH  - Decision Making/*ethics
MH  - Education, Nursing, Continuing/*ethics
MH  - Ethics, Nursing/*education
MH  - Humans
MH  - Nursing Staff/*ethics
MH  - *Power, Psychological
EDAT- 2010/06/15 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/06/15 06:00
PHST- 2009/03/11 00:00 [received]
PHST- 2009/05/14 00:00 [accepted]
PHST- 2010/06/15 06:00 [entrez]
PHST- 2010/06/15 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - 10.3928/00220124-20100601-03 [doi]
PST - ppublish
SO  - J Contin Educ Nurs. 2011 Jan;42(1):19-24; quiz 25-6. doi:
      10.3928/00220124-20100601-03. Epub 2010 Jun 8.


PMID- 20540193
OWN - NLM
STAT- MEDLINE
DCOM- 20100916
LR  - 20100611
IS  - 1293-8505 (Print)
IS  - 1293-8505 (Linking)
IP  - 161
DP  - 2010 Jun
TI  - ["My wish is that each health establishment institutes an ethics monitor"
      (interview by Sylvie Warnet)].
PG  - 4-5
FAU - Gruat, Florence
AU  - Gruat F
LA  - fre
PT  - Interview
TT  - "Mon souhait serait que chaque etablissement de sante instaure une veille
      ethique".
PL  - France
TA  - Rev Infirm
JT  - Revue de l'infirmiere
JID - 1267175
MH  - Ethics Committees/*ethics
MH  - Ethics, Institutional
MH  - *Ethics, Nursing
MH  - France
MH  - Humans
MH  - Organ Transplantation/*ethics/*nursing
MH  - Resuscitation Orders
MH  - Tissue and Organ Procurement/*ethics
EDAT- 2010/06/12 06:00
MHDA- 2010/09/18 06:00
CRDT- 2010/06/12 06:00
PHST- 2010/06/12 06:00 [entrez]
PHST- 2010/06/12 06:00 [pubmed]
PHST- 2010/09/18 06:00 [medline]
PST - ppublish
SO  - Rev Infirm. 2010 Jun;(161):4-5.


PMID- 20540172
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20220318
IS  - 1365-2346 (Electronic)
IS  - 0265-0215 (Linking)
VI  - 27
IP  - 7
DP  - 2010 Jul
TI  - Safety and efficacy of laryngeal mask airway Supreme versus laryngeal mask airway
      ProSeal: a randomized controlled trial.
PG  - 602-7
AB  - BACKGROUND AND OBJECTIVE: The Supreme laryngeal mask airway (LMA) is a new
      single-use polyvinyl chloride supraglottic device that combines the functionality
      of the ProSeal and Fastrach airways. High oropharyngeal leak pressures are
      important as they indicate airway protection, feasibility of positive pressure
      ventilation and likelihood of successful LMA placement. The oropharyngeal leak
      pressure of the LMA Supreme is not well established versus the LMA ProSeal. This 
      study was designed to compare the safety and efficacy of the LMA Supreme versus
      the LMA ProSeal in elective ambulatory procedures. METHOD: Hospital ethics board 
      approval was obtained. One hundred and five patients were consented and randomly 
      allocated to LMA Supreme or ProSeal groups. Anaesthesia was induced with
      intravenous propofol 2-3 mg kg(-1) and fentanyl 1-2 microg kg(-1) and maintained 
      with desflurane in an air-oxygen mixture. Anaesthesiologists with more than 5
      years of experience performed all of the LMA insertions. Manometry was used to
      standardize intracuff pressure at 60 cmH2O. The primary outcome was the
      oropharyngeal leak pressure. Secondary outcomes were the time and number of
      attempts for insertion, ease of insertion and the anaesthesiologist's
      satisfaction score of the airway device. The success on first attempt insertion
      was measured. Patients were interviewed postoperatively for any pharyngolaryngeal
      adverse events. RESULTS: A total of 99 patients were analysed for the primary
      outcome. The baseline demographic data for both groups were comparable. The mean 
      oropharyngeal leak pressure with the LMA Supreme was 21 +/- 5 cmH2O (95%
      confidence interval 20-22). This was significantly lower than that of the LMA
      ProSeal, 25 +/- 6 cmH2O (95% confidence interval 23-27; P<0.001). The success
      rate of the first attempt insertion was higher for the LMA Supreme than for the
      LMA ProSeal (98 and 88%, respectively; P=0.04). There was no difference in the
      median time taken for insertion with the LMA Supreme versus the LMA ProSeal: 26 s
      (interquartile range 23-45) versus 30 s (interquartile range 20-38), respectively
      (P=0.16). The ease of insertion, postoperative pharyngolaryngeal adverse events, 
      patient satisfaction scores and anaesthesiologist's satisfaction scores were
      comparable in both groups. There were no complications of aspiration or nerve
      injuries. CONCLUSION: The LMA Supreme has lower oropharyngeal leak pressures than
      the LMA ProSeal. The success of the first attempt insertion was higher for the
      LMA Supreme. The LMA Supreme is a safe, efficacious and easy-to-use disposable
      supraglottic airway device in elective ambulatory procedures. The higher rate of 
      success on first attempt insertion may make it more suitable as an airway rescue 
      device.
FAU - Seet, Edwin
AU  - Seet E
AD  - Department of Anesthesia, University Health Network, University of Toronto,
      Toronto, Ontario, Canada.
FAU - Rajeev, Subramanyam
AU  - Rajeev S
FAU - Firoz, Tamal
AU  - Firoz T
FAU - Yousaf, Farhanah
AU  - Yousaf F
FAU - Wong, Jean
AU  - Wong J
FAU - Wong, David T
AU  - Wong DT
FAU - Chung, Frances
AU  - Chung F
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - Eur J Anaesthesiol
JT  - European journal of anaesthesiology
JID - 8411711
SB  - IM
CIN - Eur J Anaesthesiol. 2010 Aug;27(8):757-8; author reply 758-9. PMID: 20404730
CIN - Eur J Anaesthesiol. 2010 Jul;27(7):585. PMID: 20523218
CIN - Acta Anaesthesiol Taiwan. 2016 Jun;54(2):44-50. PMID: 27106162
MH  - Adult
MH  - Ambulatory Surgical Procedures
MH  - Anesthesia, General/adverse effects/*instrumentation
MH  - Deglutition Disorders/etiology
MH  - Disposable Equipment
MH  - Dysphonia/etiology
MH  - Elective Surgical Procedures
MH  - Equipment Design
MH  - Equipment Failure
MH  - Female
MH  - Humans
MH  - *Laryngeal Masks/adverse effects
MH  - Male
MH  - Middle Aged
MH  - Pharyngitis/etiology
MH  - Pressure
MH  - Prospective Studies
EDAT- 2010/06/12 06:00
MHDA- 2010/09/15 06:00
CRDT- 2010/06/12 06:00
PHST- 2010/06/12 06:00 [entrez]
PHST- 2010/06/12 06:00 [pubmed]
PHST- 2010/09/15 06:00 [medline]
AID - 10.1097/eja.0b013e32833679e3 [doi]
PST - ppublish
SO  - Eur J Anaesthesiol. 2010 Jul;27(7):602-7. doi: 10.1097/eja.0b013e32833679e3.


PMID- 20539309
OWN - NLM
STAT- MEDLINE
DCOM- 20100927
LR  - 20211020
IS  - 1469-3178 (Electronic)
IS  - 1469-221X (Linking)
VI  - 11
IP  - 7
DP  - 2010 Jul
TI  - Improving transparency and ethical accountability in animal studies: three ways
      to link ethical approvals to publications.
PG  - 500-3
LID - 10.1038/embor.2010.91 [doi]
FAU - Varga, Orsolya
AU  - Varga O
AD  - Institute for Molecular and Cell Biology (IBMC) in Porto, Portugal.
      ovarga@ibmc.up.pt
FAU - Hansen, Axel Kornerup
AU  - Hansen AK
FAU - Sandoe, Peter
AU  - Sandoe P
FAU - Olsson, I Anna S
AU  - Olsson IA
LA  - eng
PT  - Journal Article
DEP - 20100611
PL  - England
TA  - EMBO Rep
JT  - EMBO reports
JID - 100963049
SB  - IM
MH  - Animal Experimentation/*ethics
MH  - Animal Welfare
MH  - Animals
MH  - Databases, Factual
MH  - Humans
MH  - Publications/*ethics/*legislation & jurisprudence
MH  - *Social Responsibility
PMC - PMC2897124
EDAT- 2010/06/12 06:00
MHDA- 2010/09/29 06:00
CRDT- 2010/06/12 06:00
PHST- 2010/02/10 00:00 [received]
PHST- 2010/05/21 00:00 [accepted]
PHST- 2010/06/12 06:00 [entrez]
PHST- 2010/06/12 06:00 [pubmed]
PHST- 2010/09/29 06:00 [medline]
AID - embor201091 [pii]
AID - 10.1038/embor.2010.91 [doi]
PST - ppublish
SO  - EMBO Rep. 2010 Jul;11(7):500-3. doi: 10.1038/embor.2010.91. Epub 2010 Jun 11.


PMID- 20539284
OWN - NLM
STAT- MEDLINE
DCOM- 20100920
LR  - 20211020
IS  - 1750-2799 (Electronic)
IS  - 1750-2799 (Linking)
VI  - 5
IP  - 6
DP  - 2010 Jun
TI  - Efficient siRNA-mediated prolonged gene silencing in human amniotic fluid stem
      cells.
PG  - 1081-95
LID - 10.1038/nprot.2010.74 [doi]
AB  - Human amniotic fluid stem cells (hAFSCs) are a very promising new type of fetal
      stem cells with numerous applications for basic science and cell-based therapies.
      They harbor a high differentiation potential and a low risk for tumor
      development, can be grown in large quantities and do not raise the ethical
      concerns associated with embryonic stem cells. RNA interference (RNAi) is a
      powerful technology to explain specific gene functions and has important
      implications for the clinical usage of tissue engineering. We provide a
      straightforward, 72-h-long protocol for siRNA-mediated gene silencing in hAFSCs. 
      The lipid-based forward transfection protocol described in this article is the
      first RNAi approach for prolonged gene knockdown in hAFSCs. This protocol allows 
      efficient, functional and reproducible gene knockdown in human stem cells over a 
      prolonged period of time (approximately 2 weeks). We also show the successful use
      of this protocol in primary nontransformed nonimmortalized fibroblasts, cervical 
      adenocarcinoma cells, transformed embryonic kidney cells, immortalized
      endometrial stromal cells and acute monocytic leukemia cells, suggesting a wide
      spectrum of applications in various cell types.
FAU - Rosner, Margit
AU  - Rosner M
AD  - Medical Genetics, Medical University Vienna, Vienna, Austria.
FAU - Siegel, Nicol
AU  - Siegel N
FAU - Fuchs, Christiane
AU  - Fuchs C
FAU - Slabina, Nina
AU  - Slabina N
FAU - Dolznig, Helmut
AU  - Dolznig H
FAU - Hengstschlager, Markus
AU  - Hengstschlager M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100520
PL  - England
TA  - Nat Protoc
JT  - Nature protocols
JID - 101284307
RN  - 0 (RNA, Small Interfering)
SB  - IM
MH  - Amniotic Fluid/*cytology
MH  - Embryonic Stem Cells/*cytology/*metabolism
MH  - Female
MH  - Gene Knockdown Techniques/*methods
MH  - Genetic Engineering/methods
MH  - Humans
MH  - In Vitro Techniques
MH  - Pregnancy
MH  - RNA Interference
MH  - RNA, Small Interfering/*genetics
MH  - Transfection
EDAT- 2010/06/12 06:00
MHDA- 2010/09/21 06:00
CRDT- 2010/06/12 06:00
PHST- 2010/06/12 06:00 [entrez]
PHST- 2010/06/12 06:00 [pubmed]
PHST- 2010/09/21 06:00 [medline]
AID - nprot.2010.74 [pii]
AID - 10.1038/nprot.2010.74 [doi]
PST - ppublish
SO  - Nat Protoc. 2010 Jun;5(6):1081-95. doi: 10.1038/nprot.2010.74. Epub 2010 May 20.


PMID- 20539020
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20220316
IS  - 1538-6724 (Electronic)
IS  - 0031-9023 (Linking)
VI  - 90
IP  - 8
DP  - 2010 Aug
TI  - Understanding the lived experiences of patients: application of a
      phenomenological approach to ethics.
PG  - 1185-97
LID - 10.2522/ptj.20090348 [doi]
AB  - This perspective article provides a justification, with an overview, of the use
      of phenomenological inquiry and the interpretation into the everyday ethical
      concerns of patients with disabilities. Disability is explored as a
      transformative process that involves physical, cognitive, and moral changes. This
      perspective article discusses the advantages of phenomenology to supplement and
      enhance the principlist process of ethical decision making that guides much of
      contemporary medical practice, including physical therapy. A phenomenological
      approach provides a more contextual approach to ethical decision making through
      probing, uncovering, and interpreting the meanings of "stories" of patients. This
      approach, in turn, provides for a more coherent and genuine application of
      ethical principles within the "textured life-world" of patients and their
      evolving values as they grapple with disability to make ethical and clinical
      decisions. The article begins with an in-depth discussion of the current
      literature about the phenomenology of people with disability. This literature
      review is followed by a discussion of the traditional principlist approach to
      making ethical decisions, which, in turn, is followed by a discussion of
      phenomenology and its tools for use in clinical inquiry and interpretation of the
      experiences of patients with disabilities. A specific case is presented that
      illustrates specific tools of phenomenology to uncover the moral context of
      disability from the perspective of patients. The article concludes with a
      discussion of clinical, educational, and research implications of a
      phenomenological approach to ethics and clinical decision making.
FAU - Greenfield, Bruce H
AU  - Greenfield BH
AD  - Division of Physical Therapy, Department of Rehabilitation, Emory University
      School of Medicine, Atlanta, GA 30322, USA. bgreenf@emory.edu
FAU - Jensen, Gail M
AU  - Jensen GM
LA  - eng
PT  - Journal Article
DEP - 20100610
PL  - United States
TA  - Phys Ther
JT  - Physical therapy
JID - 0022623
SB  - IM
CIN - Phys Ther. 2010 Aug;90(8):1197-200; author reply 200-1. PMID: 20675296
MH  - Decision Making
MH  - Disabled Persons/*rehabilitation
MH  - *Ethics, Clinical
MH  - *Ethics, Medical
MH  - Humans
MH  - Physical Therapy Specialty/*ethics
MH  - Professional-Patient Relations/*ethics
EDAT- 2010/06/12 06:00
MHDA- 2010/09/16 06:00
CRDT- 2010/06/12 06:00
PHST- 2010/06/12 06:00 [entrez]
PHST- 2010/06/12 06:00 [pubmed]
PHST- 2010/09/16 06:00 [medline]
AID - ptj.20090348 [pii]
AID - 10.2522/ptj.20090348 [doi]
PST - ppublish
SO  - Phys Ther. 2010 Aug;90(8):1185-97. doi: 10.2522/ptj.20090348. Epub 2010 Jun 10.


PMID- 20538739
OWN - NLM
STAT- MEDLINE
DCOM- 20100802
LR  - 20191210
IS  - 1471-6771 (Electronic)
IS  - 0007-0912 (Linking)
VI  - 105
IP  - 2
DP  - 2010 Aug
TI  - Diagnostic accuracy of modified transoesophageal echocardiography for
      pre-incision assessment of aortic atherosclerosis in cardiac surgery patients.
PG  - 131-8
LID - 10.1093/bja/aeq122 [doi]
AB  - BACKGROUND: Epiaortic ultrasound scanning (EUS) is regarded as the reference
      standard for detecting atherosclerosis in the ascending aorta (AA). Combined with
      appropriate surgical modifications, EUS use can significantly reduce the
      incidence of postoperative stroke when detecting severe AA atherosclerosis. A
      recently introduced modification of conventional transoesophageal
      echocardiography (TOE), known as the A-View method, has proven capable of
      inspecting the distal AA. The objective of this study was to quantify the
      diagnostic accuracy of modified TOE in assessing atherosclerosis of the distal
      AA. METHODS: After approval by the institutional medical ethical committee and
      after obtaining written informed consent, 465 consecutive patients above 65 yr
      old, undergoing elective cardiac surgery with a median sternotomy, were included.
      The study followed a cross-sectional diagnostic design. All consecutive patients 
      underwent modified TOE followed by EUS (reference standard) to assess the
      severity of distal AA atherosclerosis. We constructed contingency tables to
      compare the presence (and severity) of atherosclerosis, detected by the two
      techniques. RESULTS: The positive predictive value of modified TOE for the
      detection of clinically significant atherosclerosis was 67%, and the negative
      predictive value was 97%. The sensitivity was 95% and the specificity was 79%.
      One patient suffered a pulmonary haemorrhage, although he recovered without
      further sequelae. We did not observe any clinical significant haemodynamic or
      ventilatory effects. CONCLUSIONS: The high negative predictive value and
      sensitivity show that modified TOE yields adequate diagnostic accuracy for
      excluding clinically relevant aorta atherosclerosis without significant
      cardiopulmonary side-effects, provided that the A-View catheter is introduced
      carefully.
FAU - van Zaane, B
AU  - van Zaane B
AD  - Division of Perioperative Care and Emergency Medicine, University Medical Center 
      Utrecht, Utrecht, The Netherlands. b.vanzaane@umcutrecht.nl
FAU - Nierich, A P
AU  - Nierich AP
FAU - Brandon Bravo Bruinsma, G J
AU  - Brandon Bravo Bruinsma GJ
FAU - Rosseel, P M J
AU  - Rosseel PM
FAU - Ramjankhan, F Z
AU  - Ramjankhan FZ
FAU - de Waal, E E C
AU  - de Waal EE
FAU - Buhre, W F
AU  - Buhre WF
FAU - Moons, K G M
AU  - Moons KG
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20100610
PL  - England
TA  - Br J Anaesth
JT  - British journal of anaesthesia
JID - 0372541
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aortic Valve Stenosis/complications/*diagnostic imaging
MH  - Atherosclerosis/complications/*diagnostic imaging
MH  - *Cardiac Surgical Procedures/adverse effects
MH  - Echocardiography, Transesophageal/adverse effects/*methods
MH  - Epidemiologic Methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Preoperative Care/*methods
MH  - Sternum/surgery
MH  - Stroke/etiology/prevention & control
EDAT- 2010/06/12 06:00
MHDA- 2010/08/03 06:00
CRDT- 2010/06/12 06:00
PHST- 2010/06/12 06:00 [entrez]
PHST- 2010/06/12 06:00 [pubmed]
PHST- 2010/08/03 06:00 [medline]
AID - S0007-0912(17)33531-6 [pii]
AID - 10.1093/bja/aeq122 [doi]
PST - ppublish
SO  - Br J Anaesth. 2010 Aug;105(2):131-8. doi: 10.1093/bja/aeq122. Epub 2010 Jun 10.


PMID- 20538395
OWN - NLM
STAT- MEDLINE
DCOM- 20100811
LR  - 20180304
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 71
IP  - 3
DP  - 2010 Aug
TI  - Design-based regulation and patient safety: a regulatory studies perspective.
PG  - 502-509
LID - S0277-9536(10)00347-3 [pii]
LID - 10.1016/j.socscimed.2010.04.017 [doi]
AB  - The optimal choice of regulatory approach for securing patient safety is an
      important problem. In this review article, we show how insights from the field of
      regulatory studies can provide a conceptual apparatus for analysis of important
      problems in the regulation of medicine and healthcare. Design-based regulation
      operates through technical constraints that are self-executing. Technology, by
      concretising rules about proper behaviour and conduct, not only functions as a
      regulatory instrument, but may also encode particular values and versions of
      rationality. As debates in the broader area of "code" or "design"-based
      regulation, including the crime prevention context have highlighted, design-based
      approaches may have significant social, political and ethical implications.
      Though design-based regulation can be an attractive solution where there is
      widespread agreement about what constitutes good medical practice, it is
      considerably more problematic where there is contestation about what constitutes 
      an error and who owns the definition of an error. Design-based regulation
      involves challenges to professional agency and authority, and engages with wider 
      debates about the regulation of the medical profession. It is vital that the
      introduction of patient safety technology is sensitive to the values and motives 
      that get encoded in design.
CI  - Copyright 2010 Elsevier Ltd. All rights reserved.
FAU - Yeung, Karen
AU  - Yeung K
AD  - Centre for Technology, Ethics, Law and Society, School of Law, King's College
      London, The Strand, London WC2R 2LS, United Kingdom. Electronic address:
      karen.yeung@kcl.ac.uk.
FAU - Dixon-Woods, Mary
AU  - Dixon-Woods M
AD  - Department of Health Sciences, University of Leicester, 2nd Floor, Adrian
      Building, Leicester LE1 7RH, United Kingdom. Electronic address: md11@le.ac.uk.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100512
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Biomedical Research/*standards
MH  - Facility Regulation and Control
MH  - Humans
MH  - Medical Errors/*prevention & control
MH  - Physician-Patient Relations
MH  - Research Design
MH  - *Safety Management
RF  - 59
EDAT- 2010/06/12 06:00
MHDA- 2010/08/12 06:00
CRDT- 2010/06/12 06:00
PHST- 2009/08/17 00:00 [received]
PHST- 2010/03/10 00:00 [revised]
PHST- 2010/04/15 00:00 [accepted]
PHST- 2010/06/12 06:00 [entrez]
PHST- 2010/06/12 06:00 [pubmed]
PHST- 2010/08/12 06:00 [medline]
AID - S0277-9536(10)00347-3 [pii]
AID - 10.1016/j.socscimed.2010.04.017 [doi]
PST - ppublish
SO  - Soc Sci Med. 2010 Aug;71(3):502-509. doi: 10.1016/j.socscimed.2010.04.017. Epub
      2010 May 12.


PMID- 20538256
OWN - NLM
STAT- MEDLINE
DCOM- 20101021
LR  - 20151119
IS  - 1879-1883 (Electronic)
IS  - 0002-9610 (Linking)
VI  - 200
IP  - 4
DP  - 2010 Oct
TI  - Structured teaching versus experiential learning of palliative care for surgical 
      residents.
PG  - 542-7
LID - 10.1016/j.amjsurg.2009.12.014 [doi]
AB  - BACKGROUND: Previous end-of-life and palliative care curricula for surgical
      residents have shown improved learner confidence, but have not measured cognitive
      knowledge or skill acquisition. METHODS: A nonrandomized trial evaluated a
      structured palliative care curriculum for 7 postgraduate year 2 surgical
      residents (intervention group) compared with 6 postgraduate year 5 surgical
      residents (comparison group). Outcomes were measured using an 18-item knowledge
      test, a 20-minute objective structured clinical examination simulating an
      intensive care unit family conference, and a survey measuring self-confidence.
      RESULTS: The mean knowledge test scores for the intervention group, both before
      and after undergoing the structured palliative care curriculum, were no different
      from the comparison group. There was also no difference in objective structured
      clinical examination scores between the 2 groups. The intervention group felt
      less comfortable managing pain, breaking bad news, or addressing ethical issues. 
      CONCLUSIONS: Junior surgical residents have similar palliative care knowledge to 
      senior residents without a palliative care curriculum. After participating in a
      palliative care curriculum, they have simulated skills that are similar to chief 
      residents. However, self-confidence is lower among junior residents despite
      undergoing a palliative care curriculum.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Bradley, Ciaran T
AU  - Bradley CT
AD  - Department of Surgery, Medical College of Wisconsin, 9200 W. Wisconsin Ave.,
      Milwaukee, WI 53226, USA. cbradley@mcw.edu
FAU - Webb, Travis P
AU  - Webb TP
FAU - Schmitz, Connie C
AU  - Schmitz CC
FAU - Chipman, Jeffrey G
AU  - Chipman JG
FAU - Brasel, Karen J
AU  - Brasel KJ
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
DEP - 20100609
PL  - United States
TA  - Am J Surg
JT  - American journal of surgery
JID - 0370473
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Clinical Competence
MH  - Curriculum
MH  - Female
MH  - General Surgery/*education
MH  - Humans
MH  - Internship and Residency/*methods
MH  - *Learning
MH  - Male
MH  - Middle Aged
MH  - Palliative Care/*methods
MH  - Reproducibility of Results
MH  - Surveys and Questionnaires
MH  - Teaching/*methods
EDAT- 2010/06/12 06:00
MHDA- 2010/10/22 06:00
CRDT- 2010/06/12 06:00
PHST- 2009/09/18 00:00 [received]
PHST- 2009/11/29 00:00 [revised]
PHST- 2009/12/08 00:00 [accepted]
PHST- 2010/06/12 06:00 [entrez]
PHST- 2010/06/12 06:00 [pubmed]
PHST- 2010/10/22 06:00 [medline]
AID - S0002-9610(10)00132-7 [pii]
AID - 10.1016/j.amjsurg.2009.12.014 [doi]
PST - ppublish
SO  - Am J Surg. 2010 Oct;200(4):542-7. doi: 10.1016/j.amjsurg.2009.12.014. Epub 2010
      Jun 9.


PMID- 20538153
OWN - NLM
STAT- MEDLINE
DCOM- 20100715
LR  - 20121115
IS  - 1557-8240 (Electronic)
IS  - 0031-3955 (Linking)
VI  - 57
IP  - 3
DP  - 2010 Jun
TI  - Gene doping: the hype and the harm.
PG  - 719-27
LID - 10.1016/j.pcl.2010.02.006 [doi]
AB  - "Gene doping" is the term used to describe the potential abuse of gene therapy as
      a performance-enhancing agent. Gene doping would apply the techniques used in
      gene therapy to provide altered expression of genes that would promote physical
      superiority. For example, insulin-like growth factor 1 (IGF-1) is a primary
      target for growth hormone; overexpression of IGF-1 can lead to increased muscle
      mass and power. Although gene doping is still largely theoretical, its
      implications for sports, health, ethics, and medical genetics are significant.
FAU - McKanna, Trudy A
AU  - McKanna TA
AD  - Spectrum Health Genetic Services, Grand Rapids, MI 49503, USA.
      trudy.mckanna@spectrum-health.org
FAU - Toriello, Helga V
AU  - Toriello HV
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Pediatr Clin North Am
JT  - Pediatric clinics of North America
JID - 0401126
RN  - 0 (Bone Morphogenetic Proteins)
RN  - 12629-01-5 (Human Growth Hormone)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Animals
MH  - *Athletic Performance
MH  - Bone Morphogenetic Proteins/*genetics
MH  - Doping in Sports/*methods
MH  - Gene Transfer Techniques
MH  - *Genetic Enhancement
MH  - Genetic Therapy/*methods
MH  - Human Growth Hormone/*genetics
MH  - Humans
MH  - Insulin-Like Growth Factor I/*genetics
MH  - Mutation
MH  - Polymorphism, Genetic
MH  - Risk Factors
RF  - 27
EDAT- 2010/06/12 06:00
MHDA- 2010/07/16 06:00
CRDT- 2010/06/12 06:00
PHST- 2010/06/12 06:00 [entrez]
PHST- 2010/06/12 06:00 [pubmed]
PHST- 2010/07/16 06:00 [medline]
AID - S0031-3955(10)00028-3 [pii]
AID - 10.1016/j.pcl.2010.02.006 [doi]
PST - ppublish
SO  - Pediatr Clin North Am. 2010 Jun;57(3):719-27. doi: 10.1016/j.pcl.2010.02.006.


PMID- 20537948
OWN - NLM
STAT- MEDLINE
DCOM- 20100928
LR  - 20140818
IS  - 1474-5488 (Electronic)
IS  - 1470-2045 (Linking)
VI  - 11
IP  - 9
DP  - 2010 Sep
TI  - Effect of genome-wide association studies, direct-to-consumer genetic testing,
      and high-speed sequencing technologies on predictive genetic counselling for
      cancer risk.
PG  - 890-8
LID - 10.1016/S1470-2045(09)70359-6 [doi]
AB  - Genetic counselling is offered to patients with various hereditary cancers.
      At-risk family members can be identified by predictive testing and included in
      specifically designed screening and prevention programmes. Since genetic testing 
      has far-reaching ethical and medical outcomes, it is usually done according to
      well-defined guidelines developed by medical societies, entailing extensive
      interaction between family members and medical health providers. This established
      procedure is now changing after three new developments. First, data from
      genome-wide association studies have identified many new loci in the human
      genome, which could moderately change cancer risk. Second, although inclusion of 
      low-risk cancer genes in patients' risk assessments represents an unresolved
      challenge, several companies already offer such tests in a direct-to-consumer
      format over the internet. These tests shift control of genetic testing from
      medical professionals to individuals. Third, development of high-speed sequencing
      technologies multiplies available genomic data and enables rapid sequencing of
      entire human genomes at low costs. This innovation will pave the way for
      personalised genetics and new options for predictive testing. Here, we use the
      example of genetic counselling in colon cancer to describe how these developments
      will change genetic testing in families at risk of cancer and in the general
      population.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Speicher, Michael R
AU  - Speicher MR
AD  - Medical University of Graz, Institute of Human Genetics, Graz, Austria.
      michael.speicher@medunigraz.at
FAU - Geigl, Jochen B
AU  - Geigl JB
FAU - Tomlinson, Ian P
AU  - Tomlinson IP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100525
PL  - England
TA  - Lancet Oncol
JT  - The Lancet. Oncology
JID - 100957246
SB  - IM
MH  - *Genetic Counseling
MH  - Genetic Testing/*methods/*trends
MH  - *Genome-Wide Association Study
MH  - Humans
MH  - Neoplasms/*genetics
RF  - 69
EDAT- 2010/06/12 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/06/12 06:00
PHST- 2010/06/12 06:00 [entrez]
PHST- 2010/06/12 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - S1470-2045(09)70359-6 [pii]
AID - 10.1016/S1470-2045(09)70359-6 [doi]
PST - ppublish
SO  - Lancet Oncol. 2010 Sep;11(9):890-8. doi: 10.1016/S1470-2045(09)70359-6. Epub 2010
      May 25.


PMID- 20537771
OWN - NLM
STAT- MEDLINE
DCOM- 20110421
LR  - 20181201
IS  - 1532-2793 (Electronic)
IS  - 0260-6917 (Linking)
VI  - 31
IP  - 1
DP  - 2011 Jan
TI  - Preceptorship in the intergenerational context: an integrative review of the
      literature.
PG  - 82-7
LID - 10.1016/j.nedt.2010.04.002 [doi]
AB  - Preceptorship is a teaching/learning method used in many undergraduate nursing
      programs whereby learners are individually assigned to expert practitioners in
      the clinical setting. The current reality in today's workplace setting
      encompasses four generations (Veterans, Baby Boomers, Generation X, and
      Millennials) working together and often these generations do not share the same
      work ethic or expectations. Given this generational diversity, increased
      knowledge and awareness of the intergenerational context of the preceptorship
      experience is both an important and timely topic for nursing education. The
      purpose of this paper is to discuss an integrative review of the literature using
      the methodology of Whittemore and Knafl (2005). The computerized databases of
      CINAHL, PubMed, ProQuest Education, ERIC, and EMBASE were used to generate
      relevant literature. The sample consisted of 98 articles; 18 being research and
      80 theoretical. Given the large sample size, the authors focus on summarizing the
      research literature in this paper. This review calls attention to the need for
      further research into generational diversity and its influence on the
      preceptorship experience. It also highlights the limited research that currently 
      exists on the topic of the intergenerational nursing workforce. Implications for 
      nursing education and clinical practice are also discussed.
CI  - 2010 Elsevier Ltd. All rights reserved.
FAU - Earle, Vicki
AU  - Earle V
AD  - School of Nursing, University of Prince Edward Island, 550 University Avenue,
      Charlottetown, Prince Edward Island, Canada, C1A 4P3. earlevicki@yahoo.ca
FAU - Myrick, Florence
AU  - Myrick F
FAU - Yonge, Olive
AU  - Yonge O
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100526
PL  - Scotland
TA  - Nurse Educ Today
JT  - Nurse education today
JID - 8511379
MH  - Canada
MH  - Education, Nursing/*methods/trends
MH  - Humans
MH  - *Intergenerational Relations
MH  - Learning
MH  - Nurses/*supply & distribution/trends
MH  - *Nursing
MH  - Personnel Selection
MH  - Personnel Turnover
MH  - *Preceptorship
MH  - Teaching/*methods/trends
MH  - Workforce
EDAT- 2010/06/12 06:00
MHDA- 2011/04/22 06:00
CRDT- 2010/06/12 06:00
PHST- 2009/10/30 00:00 [received]
PHST- 2010/04/02 00:00 [accepted]
PHST- 2010/06/12 06:00 [entrez]
PHST- 2010/06/12 06:00 [pubmed]
PHST- 2011/04/22 06:00 [medline]
AID - S0260-6917(10)00078-X [pii]
AID - 10.1016/j.nedt.2010.04.002 [doi]
PST - ppublish
SO  - Nurse Educ Today. 2011 Jan;31(1):82-7. doi: 10.1016/j.nedt.2010.04.002. Epub 2010
      May 26.


PMID- 20537753
OWN - NLM
STAT- MEDLINE
DCOM- 20101102
LR  - 20220310
IS  - 1600-0641 (Electronic)
IS  - 0168-8278 (Linking)
VI  - 53
IP  - 2
DP  - 2010 Aug
TI  - Clinical efficacy of transjugular intrahepatic portosystemic shunt created with
      covered stents with different diameters: results of a randomized controlled
      trial.
PG  - 267-72
LID - 10.1016/j.jhep.2010.02.033 [doi]
AB  - BACKGROUND & AIMS: The incidence of post-TIPS hepatic encephalopathy (HE) could
      be reduced by using stents with a small diameter. The aim of this study was to
      compare the incidence of HE and the clinical efficacy of TIPS created with 8- or 
      10-mm PTFE-covered stents. METHODS: Consecutive cirrhotics submitted to TIPS for 
      variceal bleeding or refractory ascites were randomized to receive a 8- or 10-mm 
      covered stent. As recommended by our Ethical Committee, the trial was stopped
      after the inclusion of 45 patients. RESULTS: The two groups were comparable for
      age, sex, etiology, and psychometric performance. After TIPS, the portosystemic
      pressure gradient was significantly higher in the 8-mm stent group (8.9+/-2.7
      versus 6.5+/-2.7 mmHg; p=0.007). Consequently, the probability of remaining free 
      of complications due to portal hypertension was significantly higher in the 10-mm
      than in the 8-mm stent group: 82.9% versus 41.9% at one year; log-rank test,
      p=0.002. In particular, the persistence of ascites with the need for repeated
      paracentesis was significantly more frequent in the patients treated with 8-mm
      stent diameter for refractory ascites (log-rank test, p=0.008). The probability
      of remaining free of HE was similar in both groups. Cumulative survival rate was 
      similar in both groups. CONCLUSIONS: The use of 8-mm diameter stents for TIPS
      leads to a significantly less efficient control of complications of portal
      hypertension. HE remains an unsolved major problem after TIPS.
CI  - Copyright 2010 European Association for the Study of the Liver. Published by
      Elsevier B.V. All rights reserved.
FAU - Riggio, Oliviero
AU  - Riggio O
AD  - II Gastroenterologia, Dipartimento di Medicina Clinica, La Sapienza Universita di
      Roma, Italy. oliviero.riggio@uniroma1.it
FAU - Ridola, Lorenzo
AU  - Ridola L
FAU - Angeloni, Stefania
AU  - Angeloni S
FAU - Cerini, Federica
AU  - Cerini F
FAU - Pasquale, Chiara
AU  - Pasquale C
FAU - Attili, Adolfo Francesco
AU  - Attili AF
FAU - Fanelli, Fabrizio
AU  - Fanelli F
FAU - Merli, Manuela
AU  - Merli M
FAU - Salvatori, Filippo Maria
AU  - Salvatori FM
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20100427
PL  - Netherlands
TA  - J Hepatol
JT  - Journal of hepatology
JID - 8503886
SB  - IM
MH  - Adult
MH  - Aged
MH  - Ascites/etiology/therapy
MH  - Female
MH  - Hepatic Encephalopathy/epidemiology/etiology/*prevention & control
MH  - Humans
MH  - Hypertension, Portal/complications/mortality/*surgery
MH  - Incidence
MH  - Liver Cirrhosis/complications/mortality/*surgery
MH  - Male
MH  - Middle Aged
MH  - Paracentesis
MH  - Portasystemic Shunt, Transjugular Intrahepatic/*adverse
      effects/*instrumentation/methods
MH  - Psychometrics
MH  - *Stents
MH  - Survival Rate
MH  - Treatment Outcome
EDAT- 2010/06/12 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/06/12 06:00
PHST- 2009/12/01 00:00 [received]
PHST- 2010/02/25 00:00 [revised]
PHST- 2010/02/25 00:00 [accepted]
PHST- 2010/06/12 06:00 [entrez]
PHST- 2010/06/12 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - S0168-8278(10)00329-6 [pii]
AID - 10.1016/j.jhep.2010.02.033 [doi]
PST - ppublish
SO  - J Hepatol. 2010 Aug;53(2):267-72. doi: 10.1016/j.jhep.2010.02.033. Epub 2010 Apr 
      27.


PMID- 20537302
OWN - NLM
STAT- MEDLINE
DCOM- 20110107
LR  - 20101129
IS  - 1097-6868 (Electronic)
IS  - 0002-9378 (Linking)
VI  - 203
IP  - 6
DP  - 2010 Dec
TI  - Ethics: an essential dimension of soliciting philanthropic gifts from donors.
PG  - 540.e1-4
LID - 10.1016/j.ajog.2010.04.032 [doi]
AB  - Obstetrics and gynecology continues to experience fiscal pressures that challenge
      its core missions. In such an increasingly economically unforgiving environment, 
      philanthropy will become a major source of revenue. This article provides ethical
      guidance for seeking philanthropic gifts by translating ethical theory into
      practice. The basis for this guidance is an account of the ethics of philanthropy
      that identifies both its consequentialist and deontologic components and shows
      their relevance to the ethical significance of donors' motivations and
      directiveness. The prevention of abuse of vulnerable donors and of distortions of
      the physician-patient relationship is emphasized. Ethics is an essential
      component of the responsible solicitation of philanthropic support from donors.
CI  - Copyright (c) 2010 Mosby, Inc. All rights reserved.
FAU - Chervenak, Frank A
AU  - Chervenak FA
AD  - Department of Obstetrics and Gynecology, New York Weill Cornell Medical Center,
      New York, NY, USA. fac2001@med.cornell.edu
FAU - McCullough, Laurence B
AU  - McCullough LB
FAU - Fraley, Milinda
AU  - Fraley M
FAU - Golding, Joe
AU  - Golding J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Obstet Gynecol
JT  - American journal of obstetrics and gynecology
JID - 0370476
SB  - IM
MH  - Ethics, Medical
MH  - Fund Raising/*ethics
MH  - Gift Giving/*ethics
MH  - Gynecology/*ethics
MH  - Humans
MH  - Obstetrics/*ethics
MH  - Physician-Patient Relations
MH  - United States
EDAT- 2010/06/12 06:00
MHDA- 2011/01/08 06:00
CRDT- 2010/06/12 06:00
PHST- 2010/02/28 00:00 [received]
PHST- 2010/04/02 00:00 [revised]
PHST- 2010/04/20 00:00 [accepted]
PHST- 2010/06/12 06:00 [entrez]
PHST- 2010/06/12 06:00 [pubmed]
PHST- 2011/01/08 06:00 [medline]
AID - S0002-9378(10)00486-2 [pii]
AID - 10.1016/j.ajog.2010.04.032 [doi]
PST - ppublish
SO  - Am J Obstet Gynecol. 2010 Dec;203(6):540.e1-4. doi: 10.1016/j.ajog.2010.04.032.


PMID- 20536767
OWN - NLM
STAT- MEDLINE
DCOM- 20101102
LR  - 20100611
IS  - 1466-769X (Electronic)
IS  - 1466-7681 (Linking)
VI  - 11
IP  - 3
DP  - 2010 Jul
TI  - Spirituality and reductionism: three replies.
PG  - 178-90
LID - 10.1111/j.1466-769X.2010.00439.x [doi]
AB  - Several authors have commented on my reductionist account of spirituality in
      nursing, describing it variously as naive, disrespectful, demeaning,
      paternalistic, arrogant, reifying, indicative of a closed mind, akin to
      positivism, a procrustean bed, a perpetuation of fraud, a matter of faith, an
      attempt to secure ideological power, and a perspective that puritanically forbids
      interesting philosophical topics. In responding to this list of felonies and
      misdemeanours, I try to justify my excesses by arguing that the critics have not 
      really understood what reductionism involves; that rejecting reductionism is not 
      the same as providing arguments against it; that the ethical dilemmas allegedly
      associated with reductionist views are endemic to health care; that 'reifying' is
      what believers in the spiritual realm do; and that the closed minds belong to
      those who dismiss reductionist science without having studied its achievements.
FAU - Paley, John
AU  - Paley J
AD  - University of Stirling, Stirling, UK.
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - England
TA  - Nurs Philos
JT  - Nursing philosophy : an international journal for healthcare professionals
JID - 100897394
SB  - IM
CON - Nurs Philos. 2008 Oct;9(4):277-8. PMID: 18798899
CON - Nurs Philos. 2009 Apr;10(2):137-41. PMID: 19291201
CON - Nurs Philos. 2009 Jul;10(3):203-13. PMID: 19527441
MH  - Dissent and Disputes
MH  - *Ethics, Nursing
MH  - Existentialism
MH  - Humans
MH  - Paternalism/ethics
MH  - Philosophy, Nursing
MH  - *Religion and Science
MH  - *Spirituality
EDAT- 2010/06/12 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/06/12 06:00
PHST- 2010/06/12 06:00 [entrez]
PHST- 2010/06/12 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - NUP439 [pii]
AID - 10.1111/j.1466-769X.2010.00439.x [doi]
PST - ppublish
SO  - Nurs Philos. 2010 Jul;11(3):178-90. doi: 10.1111/j.1466-769X.2010.00439.x.


PMID- 20536764
OWN - NLM
STAT- MEDLINE
DCOM- 20101102
LR  - 20120416
IS  - 1466-769X (Electronic)
IS  - 1466-7681 (Linking)
VI  - 11
IP  - 3
DP  - 2010 Jul
TI  - Scepticism about the virtue ethics approach to nursing ethics.
PG  - 151-8
LID - 10.1111/j.1466-769X.2010.00433.x [doi]
AB  - Nursing ethics centres on how nurses ought to respond to the moral situations
      that arise in their professional contexts. Nursing ethicists invoke normative
      approaches from moral philosophy. Specifically, it is increasingly common for
      nursing ethicists to apply virtue ethics to moral problems encountered by nurses.
      The point of this article is to argue for scepticism about this approach. First, 
      the research question is motivated by showing that requirements on nurses such as
      to be kind, do not suffice to establish virtue ethics in nursing because
      normative rivals (such as utilitarians) can say as much; and the teleology
      distinctive of virtue ethics does not transpose to a professional context, such
      as nursing. Next, scepticism is argued for by responding to various attempts to
      secure a role for virtue ethics in nursing. The upshot is that virtue ethics is
      best left where it belongs - in personal moral life, not professional ethics -
      and nursing ethics is best done by taking other approaches.
FAU - Holland, Stephen
AU  - Holland S
AD  - Philosophy Department, University of York, Heslington, York YO10 5DD, UK.
      smh12@york.ac.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Philos
JT  - Nursing philosophy : an international journal for healthcare professionals
JID - 100897394
SB  - IM
CIN - Nurs Philos. 2012 Apr;13(2):142-5. PMID: 22405020
MH  - Codes of Ethics
MH  - Dissent and Disputes
MH  - Empathy/*ethics
MH  - Ethical Theory
MH  - *Ethics, Nursing
MH  - Greek World
MH  - Humanism
MH  - Humans
MH  - Morals
MH  - Negativism
MH  - Nurse's Role
MH  - Nursing Theory
MH  - *Philosophy, Nursing
MH  - Problem Solving/*ethics
MH  - Professional Competence
MH  - *Virtues
EDAT- 2010/06/12 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/06/12 06:00
PHST- 2010/06/12 06:00 [entrez]
PHST- 2010/06/12 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - NUP433 [pii]
AID - 10.1111/j.1466-769X.2010.00433.x [doi]
PST - ppublish
SO  - Nurs Philos. 2010 Jul;11(3):151-8. doi: 10.1111/j.1466-769X.2010.00433.x.


PMID- 20536665
OWN - NLM
STAT- MEDLINE
DCOM- 20101001
LR  - 20151119
IS  - 1346-8138 (Electronic)
IS  - 0385-2407 (Linking)
VI  - 37
IP  - 6
DP  - 2010 Jun
TI  - Whitening efficacy of plant extracts including orchid extracts on Japanese female
      skin with melasma and lentigo senilis.
PG  - 522-30
LID - 10.1111/j.1346-8138.2010.00897.x [doi]
AB  - The purpose of this study was to assess the in vivo efficacy of a cosmetic
      formulation containing plant extracts including orchid extracts, compared to 3%
      vitamin C derivative formulated with the same excipient, in Japanese female adult
      volunteers with melasma and/or lentigo senilis. The ethics committee of Osaka
      National Hospital approved the protocol of the study. Before recruitment,
      selection and inclusion of a volunteer in this study, signed informed consent was
      obtained from each volunteer after she was given clear and precise information on
      the study, enabling her to appreciate the aim of the study and the consequences
      of her consent. Forty-eight female volunteers aged 30-60 years applied the plant 
      extracts and vitamin C derivative to one side of the face. After repeated
      application for 8 weeks, efficacy was evaluated clinically by colorimetric
      measurements and subjectively using a questionnaire. After 8 weeks of treatment, 
      both the clinical evaluations by a dermatologist and the questionnaire surveys by
      volunteers indicated that the cosmetic formulation containing plant extracts was 
      significantly effective in improving the size, brightness, color intensity,
      clarity, visibility and global appearance of the pigmented spots, and also the
      luminosity complexion and skin clarity of the face. The good agreement between
      the results of clinical evaluations and those of questionnaire surveys showed
      that the orchid-rich plant extracts possess efficacy similar to vitamin C
      derivative in whitening the skin as well as melasma and lentigo senilis on the
      face of Japanese women.
FAU - Tadokoro, Taketsugu
AU  - Tadokoro T
AD  - Department of Dermatology, Osaka National Hospital, National Hospital
      Organization, Chuo-ku, Osaka, Japan. tadokoro@onh.go.jp
FAU - Bonte, Frederic
AU  - Bonte F
FAU - Archambault, Jean C
AU  - Archambault JC
FAU - Cauchard, Jean H
AU  - Cauchard JH
FAU - Neveu, Michele
AU  - Neveu M
FAU - Ozawa, Kentaro
AU  - Ozawa K
FAU - Noguchi, Fumihito
AU  - Noguchi F
FAU - Ikeda, Aya
AU  - Ikeda A
FAU - Nagamatsu, Maki
AU  - Nagamatsu M
FAU - Shinn, Sachiko
AU  - Shinn S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Dermatol
JT  - The Journal of dermatology
JID - 7600545
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Lentigo/*drug therapy
MH  - Middle Aged
MH  - *Orchidaceae
MH  - *Phytotherapy
MH  - Plant Extracts/*therapeutic use
MH  - Surveys and Questionnaires
EDAT- 2010/06/12 06:00
MHDA- 2010/10/05 06:00
CRDT- 2010/06/12 06:00
PHST- 2010/06/12 06:00 [entrez]
PHST- 2010/06/12 06:00 [pubmed]
PHST- 2010/10/05 06:00 [medline]
AID - JDE897 [pii]
AID - 10.1111/j.1346-8138.2010.00897.x [doi]
PST - ppublish
SO  - J Dermatol. 2010 Jun;37(6):522-30. doi: 10.1111/j.1346-8138.2010.00897.x.


PMID- 20536627
OWN - NLM
STAT- MEDLINE
DCOM- 20101008
LR  - 20100611
IS  - 1745-7599 (Electronic)
IS  - 1041-2972 (Linking)
VI  - 22
IP  - 6
DP  - 2010 Jun
TI  - Prescribing generic antiepileptic drugs: Issues and concerns for nurse
      practitioners.
PG  - 300-4
LID - 10.1111/j.1745-7599.2010.00511.x [doi]
AB  - PURPOSE: To educate prescribing clinicians about bioequivalent standards for
      therapeutic equivalence of brand and generic antiepileptic drugs (AEDs) as more
      generic drugs come to market, and to increase awareness of practice and safety
      issues surrounding the use of these drugs for people with seizures. DATA SOURCES:
      Information was gathered from a search of the scientific literature as well as
      the author's clinical experience. CONCLUSIONS: Controversy exists regarding the
      therapeutic equivalence of brand and generic AEDs, even when bioequivalent
      standards are satisfied. Generic AEDs have been associated with breakthrough
      seizures and adverse events that may outweigh cost savings encouraged by
      third-party payors. Further research is needed comparing brand to generic drugs
      in a rigorous manner in order to make a consensus statement regarding the safety 
      and equivalency of generic AEDs for all patient populations. IMPLICATIONS FOR
      PRACTICE: Generic AEDs may be safely prescribed in certain situations if
      clinicians are aware of ethical, legal, and practice issues surrounding their
      use. Sufficient time should be spent educating patients, caregivers, and
      pharmacists about implications of a switch made without the knowledge of the
      patient and/or prescriber.
FAU - Barrett, Megan Weigel
AU  - Barrett MW
AD  - Baptist Neurology, Jacksonville Beach, Florida 32250, USA. mrweigel@ufl.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Am Acad Nurse Pract
JT  - Journal of the American Academy of Nurse Practitioners
JID - 8916634
RN  - 0 (Anticonvulsants)
RN  - 0 (Drugs, Generic)
MH  - Anticonvulsants/adverse effects/economics/*therapeutic use
MH  - Dose-Response Relationship, Drug
MH  - Drug Administration Schedule
MH  - Drug Prescriptions
MH  - Drug Utilization Review
MH  - Drugs, Generic/adverse effects/economics/*therapeutic use
MH  - Epilepsy/*drug therapy/economics/*nursing
MH  - Humans
MH  - Nurse Practitioners/*organization & administration
MH  - Nurse's Role
MH  - Nursing Methodology Research
MH  - Prescriptions/economics/*nursing
MH  - *Therapeutic Equivalency
MH  - United States
MH  - United States Food and Drug Administration
RF  - 61
EDAT- 2010/06/12 06:00
MHDA- 2010/10/12 06:00
CRDT- 2010/06/12 06:00
PHST- 2010/06/12 06:00 [entrez]
PHST- 2010/06/12 06:00 [pubmed]
PHST- 2010/10/12 06:00 [medline]
AID - JAAN511 [pii]
AID - 10.1111/j.1745-7599.2010.00511.x [doi]
PST - ppublish
SO  - J Am Acad Nurse Pract. 2010 Jun;22(6):300-4. doi:
      10.1111/j.1745-7599.2010.00511.x.


PMID- 20536321
OWN - NLM
STAT- MEDLINE
DCOM- 20100913
LR  - 20141120
IS  - 1939-6376 (Electronic)
IS  - 1939-6368 (Linking)
VI  - 56
IP  - 3
DP  - 2010 Jun
TI  - Use of human embryonic stem cell-based models for male reproductive toxicity
      screening.
PG  - 213-21
LID - 10.3109/19396368.2010.486470 [doi]
AB  - Male reproductive toxicity examines harmful effects of various agents on all
      aspects and developmental stages of the male reproductive system, including germ 
      cell development and spermatogenesis. In developing a model for reproductive
      toxicity screening it is important to define the developmental stage that this
      model is going to recreate in vitro and to identify critical molecular targets of
      this stage. In this review we focus our discussion on the potential for using
      embryonic stem cell (ESC)-derived models for male reproductive toxicity
      screening. The rationale for developing novel toxicity models is that despite
      significant advances in our biological understanding and clinical treatment of
      infertility, many unresolved cases still remain. This is likely due to our lack
      of knowledge about environmental influences on the critical stages of gamete
      development. Many practical and ethical difficulties are associated with the
      collection of human tissue samples to explore the unknown causes of infertility. 
      Thus, a readily available in vitro model that mimics human gamete development
      would be an extremely valuable research tool for establishing novel toxicity
      assays. ESC exhibit a high degree of similarity with primordial germ cells (PGC) 
      at the level of gene expression and molecular signaling. In addition, recent
      evidence shows that ESC can be differentiated into PGC and spermatids in culture.
      Multiple lines of evidence point to the differences between mouse and human ESC
      (hESC). In light of these data, we present the case that hESC are better suited
      as in vitro toxicity screening models than their mouse counterparts. We then
      describe some of the most promising hESC-based systems that are used today to
      model certain aspects of male gamete development and that have a potential to be 
      used for toxicity screening. We conclude by discussing the potential of these
      existing models in toxicology studies and the possibilities for their improvement
      in the future.
FAU - Krtolica, Ana
AU  - Krtolica A
AD  - SLL Sciences, StemLifeLine, Inc., San Carlos, CA 94070, USA.
      akrtolica@sllsciences.com
FAU - Giritharan, Gnanaratnam
AU  - Giritharan G
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Syst Biol Reprod Med
JT  - Systems biology in reproductive medicine
JID - 101464963
SB  - IM
MH  - Animals
MH  - Embryonic Stem Cells/*cytology
MH  - Humans
MH  - In Vitro Techniques
MH  - Male
MH  - Mice
MH  - *Models, Biological
MH  - Reproduction/*drug effects
MH  - Spermatozoa/drug effects
MH  - *Toxicity Tests
RF  - 72
EDAT- 2010/06/12 06:00
MHDA- 2010/09/14 06:00
CRDT- 2010/06/12 06:00
PHST- 2010/06/12 06:00 [entrez]
PHST- 2010/06/12 06:00 [pubmed]
PHST- 2010/09/14 06:00 [medline]
AID - 10.3109/19396368.2010.486470 [doi]
PST - ppublish
SO  - Syst Biol Reprod Med. 2010 Jun;56(3):213-21. doi: 10.3109/19396368.2010.486470.


PMID- 20535672
OWN - NLM
STAT- MEDLINE
DCOM- 20101019
LR  - 20100610
IS  - 0047-262X (Print)
VI  - 57
IP  - 3
DP  - 2010 Jun
TI  - [Disaster response: essential competence for nurses].
PG  - 5-10
AB  - Disaster nursing is an essential competence for nurses today. Nurses must enhance
      their emergency treatment abilities and internalize evacuation and
      disaster-related concepts (time, resource, situation, and person) in order to
      deliver physical, psychological, social and spiritual holistic care to disaster
      victims and their families across the disaster stage continuum (i.e., before,
      impact, and after). Core disaster nursing competence include: knowledge,
      evacuation skills and physical, psychological and social trauma impact
      interventions targeting victims. Ethical and cultural sensitivities must be
      considered, and nurses must be familiar with response procedures as well as
      master communication and negotiation skills in order to consolidate group
      cooperation. The current challenge for nurses is to reconsider their role and
      function, focusing on disaster preparedness and preparedness drills in order to
      serve as an immediate and effective resource and manager both in the immediate
      aftermath of a disaster and the following recovery / health promotion period.
      Recognition and preparedness of disaster nursing related concepts are crucial
      because nurses must be recognized for the essential role they play in global
      society.
FAU - Lee, Chun-Lan
AU  - Lee CL
AD  - School of Nursing, National Defense Medical Center, ROC.
FAU - Chiang, Li-Chi
AU  - Chiang LC
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China (Republic : 1949- )
TA  - Hu Li Za Zhi
JT  - Hu li za zhi The journal of nursing
JID - 0073267
SB  - IM
MH  - *Clinical Competence
MH  - *Disaster Planning
MH  - *Disasters
MH  - *Emergency Nursing
MH  - Humans
MH  - *Nurse's Role
EDAT- 2010/06/11 06:00
MHDA- 2010/10/20 06:00
CRDT- 2010/06/11 06:00
PHST- 2010/06/11 06:00 [entrez]
PHST- 2010/06/11 06:00 [pubmed]
PHST- 2010/10/20 06:00 [medline]
PST - ppublish
SO  - Hu Li Za Zhi. 2010 Jun;57(3):5-10.


PMID- 20535643
OWN - NLM
STAT- MEDLINE
DCOM- 20120330
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 17
IP  - 3
DP  - 2011 Sep
TI  - Ethical issues in engineering models: an operations researcher's reflections.
PG  - 539-52
LID - 10.1007/s11948-010-9215-5 [doi]
AB  - This article starts with an overview of the author's personal involvement--as an 
      Operations Research consultant--in several engineering case-studies that may
      raise ethical questions; e.g., case-studies on nuclear waste, water management,
      sustainable ecology, military tactics, and animal welfare. All these case studies
      employ computer simulation models. In general, models are meant to solve
      practical problems, which may have ethical implications for the various
      stakeholders; namely, the modelers, the clients, and the public at large. The
      article further presents an overview of codes of ethics in a variety of
      disciples. It discusses the role of mathematical models, focusing on the
      validation of these models' assumptions. Documentation of these model assumptions
      needs special attention. Some ethical norms and values may be quantified through 
      the model's multiple performance measures, which might be optimized. The
      uncertainty about the validity of the model leads to risk or uncertainty analysis
      and to a search for robust models. Ethical questions may be pressing in military 
      models, including war games. However, computer games and the related experimental
      economics may also provide a special tool to study ethical issues. Finally, the
      article briefly discusses whistleblowing. Its many references to publications and
      websites enable further study of ethical issues in modeling.
FAU - Kleijnen, J
AU  - Kleijnen J
AD  - Department of Information Management and Center for Economic Research, Tilburg
      School of Economics and Management, Tilburg University, Postbox 90153, 5000 LE,
      Tilburg, The Netherlands. kleijnen@uvt.nl
LA  - eng
PT  - Journal Article
DEP - 20100611
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Codes of Ethics
MH  - Computer Simulation/*ethics
MH  - Computers
MH  - Economics
MH  - Engineering/*ethics
MH  - *Ethics, Research
MH  - Humans
MH  - Military Personnel
MH  - *Models, Theoretical
MH  - *Social Values
MH  - Uncertainty
MH  - Warfare
MH  - Whistleblowing
PMC - PMC3183247
EDAT- 2010/06/11 06:00
MHDA- 2012/03/31 06:00
CRDT- 2010/06/11 06:00
PHST- 2010/02/09 00:00 [received]
PHST- 2010/05/19 00:00 [accepted]
PHST- 2010/06/11 06:00 [entrez]
PHST- 2010/06/11 06:00 [pubmed]
PHST- 2012/03/31 06:00 [medline]
AID - 10.1007/s11948-010-9215-5 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2011 Sep;17(3):539-52. doi: 10.1007/s11948-010-9215-5. Epub 2010 
      Jun 11.


PMID- 20535491
OWN - NLM
STAT- MEDLINE
DCOM- 20110817
LR  - 20211020
IS  - 1437-1596 (Electronic)
IS  - 0937-9827 (Linking)
VI  - 125
IP  - 3
DP  - 2011 May
TI  - Genetic analysis of sudden cardiac death victims: a survey of current forensic
      autopsy practices.
PG  - 359-66
LID - 10.1007/s00414-010-0474-0 [doi]
AB  - Autopsy-negative sudden cardiac deaths (SCD) seen in forensic practice are most
      often thought to be the result of sudden arrhythmic death syndrome. Postmortem
      genetic analysis is recommended in such cases, but is currently performed in only
      a few academic centers. In order to determine actual current practice, an on-line
      questionnaire was sent by e-mail to members of various forensic medical
      associations. The questions addressed routine procedures employed in cases of
      sudden cardiac death (autopsy ordering, macroscopic and microscopic cardiac
      examination, conduction tissue examination, immunohistochemistry and electron
      microscopy, biochemical markers, sampling and storage of material for genetic
      analyses, toxicological analyses, and molecular autopsy). Some questions
      concerned the legal and ethical aspects of genetic analyses in postmortem
      examinations, as well as any existing multidisciplinary collaborations in SCD
      cases. There were 97 respondents, mostly from European countries. Genetic testing
      in cases of sudden cardiac death is rarely practiced in routine forensic
      investigation. Approximately 60% of respondents reported not having the means to 
      perform genetic postmortem testing and 40% do not collect adequate material to
      perform these investigations at a later date, despite working at university
      hospitals. The survey demonstrated that many of the problems involved in the
      adequate investigation of SCD cases are often financial in origin, due to the
      fact that activities in forensic medicine are often paid by and dependent on the 
      judicial authorities. Problems also exist concerning the contact with family
      members and/or the family doctor, as well as the often-nonexistent collaboration 
      with others clinicians with special expertise beneficial in the investigation of 
      SCD cases, such as cardiologists and geneticists. This study highlights the
      importance in establishing guidelines for molecular autopsies in forensic
      medicine.
FAU - Michaud, Katarzyna
AU  - Michaud K
AD  - University Center of Legal Medicine Lausanne-Geneva, Bugnon 21, 1011, Lausanne,
      Switzerland. katarzyna.michaud@chuv.ch
FAU - Mangin, Patrice
AU  - Mangin P
FAU - Elger, Bernice S
AU  - Elger BS
LA  - eng
PT  - Journal Article
DEP - 20100611
PL  - Germany
TA  - Int J Legal Med
JT  - International journal of legal medicine
JID - 9101456
SB  - IM
MH  - *Autopsy/methods
MH  - Data Collection
MH  - *Death, Sudden, Cardiac/pathology
MH  - Female
MH  - *Forensic Genetics
MH  - Forensic Pathology
MH  - Heart Diseases/genetics
MH  - Humans
MH  - Male
MH  - Myocardium/pathology
EDAT- 2010/06/11 06:00
MHDA- 2011/08/19 06:00
CRDT- 2010/06/11 06:00
PHST- 2010/02/15 00:00 [received]
PHST- 2010/05/21 00:00 [accepted]
PHST- 2010/06/11 06:00 [entrez]
PHST- 2010/06/11 06:00 [pubmed]
PHST- 2011/08/19 06:00 [medline]
AID - 10.1007/s00414-010-0474-0 [doi]
PST - ppublish
SO  - Int J Legal Med. 2011 May;125(3):359-66. doi: 10.1007/s00414-010-0474-0. Epub
      2010 Jun 11.


PMID- 20535464
OWN - NLM
STAT- MEDLINE
DCOM- 20100927
LR  - 20220409
IS  - 1432-0614 (Electronic)
IS  - 0175-7598 (Linking)
VI  - 87
IP  - 4
DP  - 2010 Jul
TI  - Trends and challenges in the microbial production of lignocellulosic bioalcohol
      fuels.
PG  - 1303-15
LID - 10.1007/s00253-010-2707-z [doi]
AB  - Bioalcohols produced by microorganisms from renewable materials are promising
      substitutes for traditional fuels derived from fossil sources. For several years 
      already ethanol is produced in large amounts from feedstocks such as cereals or
      sugar cane and used as a blend for gasoline or even as a pure biofuel. However,
      alcohols with longer carbon chains like butanol have even more suitable
      properties and would better fit with the current fuel distribution
      infrastructure. Moreover, ethical concerns contradict the use of food and feed
      products as a biofuel source. Lignocellulosic biomass, especially when considered
      as a waste material offers an attractive alternative. However, the recalcitrance 
      of these materials and the inability of microorganisms to efficiently ferment
      lignocellulosic hydrolysates still prevent the production of bioalcohols from
      these plentiful sources. Obviously, no known organism exist which combines all
      the properties necessary to be a sustainable bioalcohol producer. Therefore,
      breeding technologies, genetic engineering and the search for undiscovered
      species are promising means to provide a microorganism exhibiting high alcohol
      productivities and yields, converting all lignocellulosic sugars or are even able
      to use carbon dioxide or monoxide, and thereby being highly resistant to
      inhibitors and fermentation products, and easy to cultivate in huge bioreactors. 
      In this review, we compare the properties of various microorganisms, bacteria and
      yeasts, as well as current research efforts to develop a reliable lignocellulosic
      bioalcohol producing organism.
FAU - Weber, Christian
AU  - Weber C
AD  - Institute of Molecular Biosciences, Goethe-University Frankfurt am Main,
      Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.
FAU - Farwick, Alexander
AU  - Farwick A
FAU - Benisch, Feline
AU  - Benisch F
FAU - Brat, Dawid
AU  - Brat D
FAU - Dietz, Heiko
AU  - Dietz H
FAU - Subtil, Thorsten
AU  - Subtil T
FAU - Boles, Eckhard
AU  - Boles E
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100610
PL  - Germany
TA  - Appl Microbiol Biotechnol
JT  - Applied microbiology and biotechnology
JID - 8406612
RN  - 0 (Biofuels)
RN  - 11132-73-3 (lignocellulose)
RN  - 3K9958V90M (Ethanol)
RN  - 9005-53-2 (Lignin)
SB  - IM
MH  - Bacteria/*metabolism
MH  - Biofuels/*analysis
MH  - Bioreactors/microbiology
MH  - Ethanol/*metabolism
MH  - Fungi/*metabolism
MH  - Industrial Microbiology/methods/*trends
MH  - Lignin/*metabolism
RF  - 129
EDAT- 2010/06/11 06:00
MHDA- 2010/09/29 06:00
CRDT- 2010/06/11 06:00
PHST- 2010/04/09 00:00 [received]
PHST- 2010/05/27 00:00 [accepted]
PHST- 2010/05/27 00:00 [revised]
PHST- 2010/06/11 06:00 [entrez]
PHST- 2010/06/11 06:00 [pubmed]
PHST- 2010/09/29 06:00 [medline]
AID - 10.1007/s00253-010-2707-z [doi]
PST - ppublish
SO  - Appl Microbiol Biotechnol. 2010 Jul;87(4):1303-15. doi:
      10.1007/s00253-010-2707-z. Epub 2010 Jun 10.


PMID- 20535275
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1998-3662 (Electronic)
IS  - 0971-4065 (Linking)
VI  - 20
IP  - 1
DP  - 2010 Jan
TI  - Authors should know the ethical rules of publication.
PG  - 55
LID - 10.4103/0971-4065.62087 [doi]
FAU - Yousef Khan, Fahmi
AU  - Yousef Khan F
AD  - Department of Medicine, Hamad General Hospital, Doha, Qatar.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Nephrol
JT  - Indian journal of nephrology
JID - 8914356
PMC - PMC2878415
EDAT- 2010/06/11 06:00
MHDA- 2010/06/11 06:01
CRDT- 2010/06/11 06:00
PHST- 2010/06/11 06:00 [entrez]
PHST- 2010/06/11 06:00 [pubmed]
PHST- 2010/06/11 06:01 [medline]
AID - 10.4103/0971-4065.62087 [doi]
PST - ppublish
SO  - Indian J Nephrol. 2010 Jan;20(1):55. doi: 10.4103/0971-4065.62087.


PMID- 20534221
OWN - NLM
STAT- MEDLINE
DCOM- 20101029
LR  - 20100610
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 42
IP  - 4
DP  - 2010 May
TI  - Financial incentives for organ donation: a slippery slope toward organ
      commercialism?
PG  - 1048-9
LID - 10.1016/j.transproceed.2010.03.058 [doi]
AB  - Financial incentives for organ donation (from living or brain-dead donors) have
      been considered ethically acceptable by some authors and have been accepted
      locally in some countries. In the United States of America, eight federal
      proposals have been rejected, while some kind of incentives have been approved at
      a local or state level. There is still a widespread concern that the acceptance
      of economic incentives could bring a commodification of the human body,
      constituting a "slippery slope" toward organ commercialism.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Bruzzone, P
AU  - Bruzzone P
AD  - Department of General Surgery, Surgical Sciences and Transplantation Paride
      Stefanini, Universita di Roma La Sapienza, Rome, Italy.
      paolo.bruzzone@fastwebnet.it
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - Cadaver
MH  - Commerce/*ethics
MH  - Humans
MH  - Italy
MH  - Living Donors/ethics
MH  - *Motivation
MH  - Tissue Donors/ethics
MH  - Tissue and Organ Procurement/*economics
EDAT- 2010/06/11 06:00
MHDA- 2010/10/30 06:00
CRDT- 2010/06/11 06:00
PHST- 2010/06/11 06:00 [entrez]
PHST- 2010/06/11 06:00 [pubmed]
PHST- 2010/10/30 06:00 [medline]
AID - S0041-1345(10)00346-5 [pii]
AID - 10.1016/j.transproceed.2010.03.058 [doi]
PST - ppublish
SO  - Transplant Proc. 2010 May;42(4):1048-9. doi: 10.1016/j.transproceed.2010.03.058.


PMID- 20534220
OWN - NLM
STAT- MEDLINE
DCOM- 20101029
LR  - 20100610
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 42
IP  - 4
DP  - 2010 May
TI  - Ethical and legal issues in donation after cardiac death in Italy.
PG  - 1046-7
LID - 10.1016/j.transproceed.2010.03.057 [doi]
AB  - In Italy death of a human being must be declared either after brain death or
      after 20 minutes of cardiac arrest, certified by continuous electrocardiography
      (EKG) recording. It is my personal opinion that in such circumstances after
      cardiac death (DCD) will allow at best only the retrieval of few marginal kidneys
      and some tissues, and therefore will not be very helpful for our waiting list
      patients. I suggest instead modifying first the Italian law in order to be able
      to declare cardiac death after only 5 minutes of cardiac arrest, certified by
      continuous EKG recording.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Bruzzone, P
AU  - Bruzzone P
AD  - Department of General Surgery, Paride Stefanini, Universita di Roma La Sapienza, 
      Rome, Italy. paolo.bruzzone@fastwebnet.it
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - Brain Death
MH  - Crime
MH  - *Death
MH  - Electrocardiography
MH  - Ethics, Medical
MH  - Euthanasia/legislation & jurisprudence
MH  - France
MH  - Heart Arrest
MH  - Humans
MH  - Italy
MH  - Legislation, Medical
MH  - Netherlands
MH  - Spain
MH  - Time Factors
MH  - Tissue and Organ Procurement/*ethics/*legislation & jurisprudence
EDAT- 2010/06/11 06:00
MHDA- 2010/10/30 06:00
CRDT- 2010/06/11 06:00
PHST- 2010/06/11 06:00 [entrez]
PHST- 2010/06/11 06:00 [pubmed]
PHST- 2010/10/30 06:00 [medline]
AID - S0041-1345(10)00345-3 [pii]
AID - 10.1016/j.transproceed.2010.03.057 [doi]
PST - ppublish
SO  - Transplant Proc. 2010 May;42(4):1046-7. doi: 10.1016/j.transproceed.2010.03.057.


PMID- 20534218
OWN - NLM
STAT- MEDLINE
DCOM- 20101029
LR  - 20191210
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 42
IP  - 4
DP  - 2010 May
TI  - Ethical issues with informed consent from potential living kidney donors.
PG  - 1040-2
LID - 10.1016/j.transproceed.2010.03.075 [doi]
AB  - Living organ donation and participation in clinical research trials have several 
      features in common from an ethical perspective. The primary similarity is risk
      justification: the risk of harm to living organ donors and clinical research
      participants is justified by a resulting benefit to one or more other
      individuals. Some authors hold that organ donation and clinical trial
      participation are full-fledged duties. Such an implicit likening of the two leads
      to several considerations regarding informed consent in each situation. Informed 
      consent raises ethical concerns in every medical context, and some of those
      concerns, such as competence, understanding, autonomy, and free or voluntary
      choice, are uniquely relevant to living organ donation and clinical trial
      participation. Most countries regulate informed consent procedures for living
      organ donation in great detail, and although informed consent procedures for
      clinical trial participation are somewhat less detailed, their rules are subject 
      to review by ethics committees. It would be constructive for research
      participation informed consent procedures and living organ donation informed
      consent procedures to learn from one another.
CI  - Copyright (c) 2009 Elsevier Inc. All rights reserved.
FAU - Petrini, C
AU  - Petrini C
AD  - Bioethics Unit, Office of the President, Istituto Superiore di Sanita, Rome,
      Italy. carlo.petrini@iss.it
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - Conflict, Psychological
MH  - *Ethics, Medical
MH  - Humans
MH  - Informed Consent/*ethics
MH  - *Kidney
MH  - Living Donors/*ethics
MH  - Nephrectomy/adverse effects/ethics
MH  - Personal Autonomy
MH  - Risk Assessment
MH  - Tissue and Organ Procurement/*ethics
EDAT- 2010/06/11 06:00
MHDA- 2010/10/30 06:00
CRDT- 2010/06/11 06:00
PHST- 2010/06/11 06:00 [entrez]
PHST- 2010/06/11 06:00 [pubmed]
PHST- 2010/10/30 06:00 [medline]
AID - S0041-1345(10)00363-5 [pii]
AID - 10.1016/j.transproceed.2010.03.075 [doi]
PST - ppublish
SO  - Transplant Proc. 2010 May;42(4):1040-2. doi: 10.1016/j.transproceed.2010.03.075.


PMID- 20533978
OWN - NLM
STAT- MEDLINE
DCOM- 20110330
LR  - 20101105
IS  - 1556-4029 (Electronic)
IS  - 0022-1198 (Linking)
VI  - 55
IP  - 5
DP  - 2010 Sep
TI  - Modeling forensic DNA database performance.
PG  - 1174-83
LID - 10.1111/j.1556-4029.2010.01426.x [doi]
AB  - Over the past decade or more, DNA databases have been a focal point of
      development for the forensic field. Using this approach, forensic and law
      enforcement agencies have aided millions of investigations, many of which would
      remain unsolved but for the intelligence links provided from DNA database
      comparison. However, despite their widespread use and increasingly broad
      legislative and operational reach, there has been limited overarching performance
      modeling or reflection on drivers of operational or financial efficiency. This
      study derives an inferential model for DNA database performance using data from
      major national DNA database programs. Parameters that optimize desirable database
      outputs (matches) are isolated and discussed, as is an approach for maximizing
      financial efficiency and minimizing ethical impact. This research takes important
      steps toward identifying measures of performance for forensic DNA database
      operations.
CI  - (c) 2010 American Academy of Forensic Sciences.
FAU - Walsh, Simon J
AU  - Walsh SJ
AD  - Forensic & Data Centres, Australian Federal Police, Canberra, ACT, Australia.
      simonjoseph.walsh@afp.gov.au
FAU - Curran, James M
AU  - Curran JM
FAU - Buckleton, John S
AU  - Buckleton JS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Forensic Sci
JT  - Journal of forensic sciences
JID - 0375370
SB  - IM
MH  - Crime
MH  - *Databases, Nucleic Acid/economics/ethics
MH  - Forensic Medicine
MH  - Humans
MH  - *Models, Statistical
EDAT- 2010/06/11 06:00
MHDA- 2011/03/31 06:00
CRDT- 2010/06/11 06:00
PHST- 2010/06/11 06:00 [entrez]
PHST- 2010/06/11 06:00 [pubmed]
PHST- 2011/03/31 06:00 [medline]
AID - JFO1426 [pii]
AID - 10.1111/j.1556-4029.2010.01426.x [doi]
PST - ppublish
SO  - J Forensic Sci. 2010 Sep;55(5):1174-83. doi: 10.1111/j.1556-4029.2010.01426.x.


PMID- 20533922
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20220317
IS  - 1365-2214 (Electronic)
IS  - 0305-1862 (Linking)
VI  - 36
IP  - 5
DP  - 2010 Sep
TI  - Children's participation in health research: from objects to agents?
PG  - 603-11
LID - 10.1111/j.1365-2214.2010.01094.x [doi]
AB  - BACKGROUND: In the UK, there is a growing recognition of the need to include
      children's accounts in research on paediatric health care. This paper seeks to
      examine ways in which children have been included in health-related studies to
      identify strengths and weaknesses. METHODS: Key empirical based studies were
      identified via comprehensive searches of academic literature databases to
      exemplify research practices related to three ways of engaging with children in
      health-related research. These three approaches are summarized as research on
      children, with children and by children. RESULTS: Research on children engages
      with adult 'authorities', such as parents and medical professionals. This
      approach allows some access to children including those understood as
      hard-to-reach: for example, pre-speech infants, or children with complex
      developmental disabilities. Research with children includes children as
      respondents to engage directly with their own understandings. This may be
      achieved alongside adult representatives, or by focusing only on the children
      themselves. Research by children encourages children to participate in the
      research process itself. This may occur across any, or indeed, every stage from
      design to dissemination to enable children to set the agenda themselves. Each of 
      the three approaches has strengths and weaknesses, and involves some form of
      adult-mediation. CONCLUSION: Inclusion of children's perspectives can be
      achieved, at varying levels, in each approach (on, with and by) examined here.
      Although claims to authority around including children's perspectives may appear 
      to hold more credence when children have directly participated in the research,
      there may be times when this is neither possible nor appropriate. Researchers are
      challenged to be open and reflexive about ways in which children are engaged
      with, incorporated in and represented across the many stages of research.
      Whichever approach is taken, ethical issues and notions of equity remain
      problematic. This point holds particular resonance for ways in which ethics
      around children may be considered in National Health Service ethics governance
      processes.
FAU - Clavering, E K
AU  - Clavering EK
AD  - Policy, Ethics and Life Sciences (PEALS) Research Centre, Newcastle University,
      Newcastle upon Tyne, UK. e.k.clavering@ncl.ac.uk
FAU - McLaughlin, J
AU  - McLaughlin J
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100601
PL  - England
TA  - Child Care Health Dev
JT  - Child: care, health and development
JID - 7602632
SB  - IM
MH  - Age Factors
MH  - Child
MH  - Child Advocacy/*psychology
MH  - Clinical Trials as Topic/psychology
MH  - Humans
MH  - Patient Participation
MH  - Research Design/*standards
MH  - Research Subjects/*psychology
EDAT- 2010/06/11 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/06/11 06:00
PHST- 2010/06/11 06:00 [entrez]
PHST- 2010/06/11 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - CCH1094 [pii]
AID - 10.1111/j.1365-2214.2010.01094.x [doi]
PST - ppublish
SO  - Child Care Health Dev. 2010 Sep;36(5):603-11. doi:
      10.1111/j.1365-2214.2010.01094.x. Epub 2010 Jun 1.


PMID- 20533799
OWN - NLM
STAT- MEDLINE
DCOM- 20100817
LR  - 20170214
IS  - 0963-6625 (Print)
IS  - 0963-6625 (Linking)
VI  - 19
IP  - 2
DP  - 2010 Mar
TI  - Recruiting for representation in public deliberation on the ethics of biobanks.
PG  - 212-24
AB  - This paper addresses the dilemmas of participant sampling and recruitment for
      deliberative science policy projects. Results are drawn from a deliberative
      public event that was held in April and May, 2007. The research objective of The 
      BC Biobank Deliberation was to assess deliberative democracy as an approach to
      legitimate policy advice from a subset of British Columbians concerning the
      secondary use of human tissues for prospective genomic and genetic research. The 
      overall goal was to have participants identify key values that should guide a
      biobank in British Columbia. This paper assesses our team's group decision-making
      processes concerning participant sampling for the 2007 event. Results presented
      here should allow the reader to critically examine our team's choices and could
      also be used to assist advocates of deliberative democracy and others who may
      wish to propose similar events in the future.
FAU - Longstaff, Holly
AU  - Longstaff H
AD  - W. Maurice Young Centre for Applied Ethics, University of British Columbia,
      Vancouver, Canada. longstaf@interchange.ubc.ca
FAU - Burgess, Michael M
AU  - Burgess MM
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Public Underst Sci
JT  - Public understanding of science (Bristol, England)
JID - 9306503
MH  - Adult
MH  - British Columbia
MH  - Community Participation/*statistics & numerical data
MH  - *Ethics, Medical
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Public Policy
MH  - Tissue Banks/*ethics/legislation & jurisprudence
EDAT- 2010/06/11 06:00
MHDA- 2010/08/18 06:00
CRDT- 2010/06/11 06:00
PHST- 2010/06/11 06:00 [entrez]
PHST- 2010/06/11 06:00 [pubmed]
PHST- 2010/08/18 06:00 [medline]
AID - 10.1177/0963662508097626 [doi]
PST - ppublish
SO  - Public Underst Sci. 2010 Mar;19(2):212-24. doi: 10.1177/0963662508097626.


PMID- 20533798
OWN - NLM
STAT- MEDLINE
DCOM- 20100817
LR  - 20170214
IS  - 0963-6625 (Print)
IS  - 0963-6625 (Linking)
VI  - 19
IP  - 2
DP  - 2010 Mar
TI  - Public bioethics and public engagement: the politics of "proper talk".
PG  - 197-211
AB  - This article uses notions of "public talk" and "regulation as facilitation" to
      develop an account of public bioethics in the UK as a form of scientific
      governance, drawing on document analysis and expert interviews. First, this
      article will show the "ethical" problematization of scientific governance in the 
      UK through the emergence of the Human Genetics Commission (HGC), Nuffield Council
      on Bioethics (NCB), and Human Fertilisation and Embryology Authority (HFEA).
      Second, it will argue that an "ethical" model has emerged alongside and partially
      displaced a "technical" model of expertise in scientific governance. The article 
      will introduce the notion of "proper talk," a set of techniques for facilitating 
      ethical debate, characterized by the active elicitation of public engagement and 
      the inclusion of emotions and subjectivity. The article then questions whether
      the authority to categorize publics and identify "proper" ethical positions
      reintroduces problems of expertise in a new form.
FAU - Moore, Alfred
AU  - Moore A
AD  - Department of Philosophy, University College Cork, Ireland. a.moore@ucc.ie
LA  - eng
PT  - Journal Article
PL  - England
TA  - Public Underst Sci
JT  - Public understanding of science (Bristol, England)
JID - 9306503
MH  - Attitude to Computers
MH  - *Bioethics
MH  - *Community Participation
MH  - Decision Making
MH  - France
MH  - Germany
MH  - Government Regulation
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - *Politics
MH  - Professional Competence
MH  - *Public Opinion
MH  - *Public Policy
MH  - Science/legislation & jurisprudence
MH  - United Kingdom
EDAT- 2010/06/11 06:00
MHDA- 2010/08/18 06:00
CRDT- 2010/06/11 06:00
PHST- 2010/06/11 06:00 [entrez]
PHST- 2010/06/11 06:00 [pubmed]
PHST- 2010/08/18 06:00 [medline]
AID - 10.1177/0963662508096781 [doi]
PST - ppublish
SO  - Public Underst Sci. 2010 Mar;19(2):197-211. doi: 10.1177/0963662508096781.


PMID- 20533668
OWN - NLM
STAT- MEDLINE
DCOM- 20100708
LR  - 20100610
IS  - 0029-6570 (Print)
IS  - 0029-6570 (Linking)
VI  - 24
IP  - 37
DP  - 2010 May 19-25
TI  - Introducing enteral nutrition support: ethical considerations.
PG  - 41-5
AB  - This article explores the potential benefits of, or problems associated with, the
      insertion of a feeding tube to commence enteral nutrition. Some of the issues
      that may arise when a patient is no longer able to meet their nutritional needs
      orally are discussed.
FAU - Best, Carolyn
AU  - Best C
AD  - Nutrition and Dietetic Department, Royal Hampshire County Hospital, Winchester.
      carolyn.best@wehct.nhs.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Stand
JT  - Nursing standard (Royal College of Nursing (Great Britain) : 1987)
JID - 9012906
MH  - Advance Directives
MH  - Beneficence
MH  - Enteral Nutrition/*ethics/nursing
MH  - *Ethics, Clinical
MH  - Humans
MH  - Informed Consent
MH  - Mental Competency
MH  - Personal Autonomy
EDAT- 2010/06/11 06:00
MHDA- 2010/07/09 06:00
CRDT- 2010/06/11 06:00
PHST- 2010/06/11 06:00 [entrez]
PHST- 2010/06/11 06:00 [pubmed]
PHST- 2010/07/09 06:00 [medline]
AID - 10.7748/ns2010.05.24.37.41.c7779 [doi]
PST - ppublish
SO  - Nurs Stand. 2010 May 19-25;24(37):41-5. doi: 10.7748/ns2010.05.24.37.41.c7779.


PMID- 20522581
OWN - NLM
STAT- MEDLINE
DCOM- 20100804
LR  - 20181204
IS  - 1931-3543 (Electronic)
IS  - 0012-3692 (Linking)
VI  - 137
IP  - 6 Suppl
DP  - 2010 Jun
TI  - Clinical trials for pulmonary hypertension in the developing world: pulmonary
      vascular disease: the global perspective.
PG  - 62S-68S
LID - 10.1378/chest.09-2845 [doi]
AB  - More clinical trials in pulmonary hypertension (PH) are being conducted in
      developing countries now compared with the past. This is a welcome development,
      considering the rarity of the disease, with its limited treatment options and
      poor prognosis. Conducting clinical trials in the developing world potentially
      decreases the time and costs of drug development and provides access to new drugs
      to an underserved population. However, the range of PH presentations, standards
      of care, and socioeconomic environments among developing countries is different
      from that of developed countries. Eagerness to complete clinical trials
      universally should not compromise accepted ethical practices. Patients from
      developing countries may be particularly vulnerable because of illiteracy and
      poverty and may not truly understand the informed consent process and clinical
      trials. Investigators, ethics committees, and regulators must ensure that
      potential participants are not exploited. Drug trials should be done only in
      those communities in which the drug would be made accessible if proven effective.
      Studies have to be designed taking safety, accessibility, and generalizability
      into consideration. Selecting appropriate investigators and institutions,
      supporting them with proper training, and providing infrastructure and facilities
      would promote uniform standards of clinical research across the globe.
      Coordination and cooperation among regulatory bodies of different countries is an
      urgent necessity that would facilitate the globalization of clinical research. If
      done appropriately, the potential benefit for the worldwide population of
      patients with PH would be substantial.
FAU - Sastry, Bhagavathula K S
AU  - Sastry BK
AD  - CARE Hospitals, Hyderabad, India.
FAU - McGoon, Michael D
AU  - McGoon MD
FAU - Gibbs, J Simon R
AU  - Gibbs JS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Chest
JT  - Chest
JID - 0231335
SB  - IM
MH  - *Clinical Trials as Topic/ethics/legislation & jurisprudence
MH  - *Developed Countries
MH  - Ethics, Clinical
MH  - Global Health
MH  - Health Services Accessibility
MH  - Humans
MH  - *Hypertension, Pulmonary/therapy
MH  - Safety
MH  - Social Control, Formal
EDAT- 2010/06/11 06:00
MHDA- 2010/08/05 06:00
CRDT- 2010/06/05 06:00
PHST- 2010/06/05 06:00 [entrez]
PHST- 2010/06/11 06:00 [pubmed]
PHST- 2010/08/05 06:00 [medline]
AID - S0012-3692(10)60328-5 [pii]
AID - 10.1378/chest.09-2845 [doi]
PST - ppublish
SO  - Chest. 2010 Jun;137(6 Suppl):62S-68S. doi: 10.1378/chest.09-2845.


PMID- 20517676
OWN - NLM
STAT- MEDLINE
DCOM- 20101022
LR  - 20211020
IS  - 1613-7671 (Electronic)
IS  - 0043-5325 (Linking)
VI  - 122 Suppl 2
DP  - 2010 May
TI  - Why do general practitioners not screen and intervene regarding alcohol
      consumption in Slovenia? A focus group study.
PG  - 68-73
LID - 10.1007/s00508-010-1335-z [doi]
AB  - AIM: To identify barriers influencing general practitioners' decisions regarding 
      alcohol screening and brief intervention (SBI) in Slovenia. BACKGROUND: Slovenia 
      occupies third place in a league of 51 European countries with respect to alcohol
      consumption. General practitioners in Slovenia have the majority of contacts with
      patients in primary healthcare but they rarely or never ask patients about their 
      drinking habits. METHOD: Six focus groups with a total of 32 general
      practitioners from different parts of the country were set up. Participants
      discussed varied topics and the most significant barriers were identified through
      qualitative analysis. RESULTS: The identified barriers were lack of funding,
      absence of societal support, lack of knowledge and guidelines, inadequate
      counselling skills, different interpretations regarding definitions of what
      constitutes an alcoholic beverage, lack of time, alcohol screening not considered
      to be an integral part of general practice, personal characteristics of general
      practitioners, patients' unwillingness to participate in SBI, and ethical
      dilemmas. CONCLUSION: Lack of knowledge and guidelines, and inadequate
      counselling skills can be solved through educational programs. In order to change
      drinking habits, substantial changes in public and personal attitudes towards
      alcohol consumption, involving many partners, are necessary.
FAU - Poplas Susic, Tonka
AU  - Poplas Susic T
AD  - Faculty of Medicine, Department of Family Medicine, Ljubljana, Slovenia.
      tonka.poplas-susic@mf.uni-lj.si
FAU - Kersnik, Janko
AU  - Kersnik J
FAU - Kolsek, Marko
AU  - Kolsek M
LA  - eng
PT  - Journal Article
PL  - Austria
TA  - Wien Klin Wochenschr
JT  - Wiener klinische Wochenschrift
JID - 21620870R
SB  - IM
MH  - Alcohol Drinking/adverse effects
MH  - Alcoholism/*diagnosis/*epidemiology/rehabilitation
MH  - Attitude of Health Personnel
MH  - Cross-Sectional Studies
MH  - Curriculum
MH  - Education, Medical, Continuing
MH  - Family Practice/education
MH  - Female
MH  - Focus Groups
MH  - Humans
MH  - Male
MH  - *Mass Screening
MH  - Patient Education as Topic
MH  - *Physician's Role
MH  - Practice Guidelines as Topic
MH  - Slovenia
MH  - Smoking/adverse effects
EDAT- 2010/06/11 06:00
MHDA- 2010/10/23 06:00
CRDT- 2010/06/03 06:00
PHST- 2010/06/03 06:00 [entrez]
PHST- 2010/06/11 06:00 [pubmed]
PHST- 2010/10/23 06:00 [medline]
AID - 10.1007/s00508-010-1335-z [doi]
PST - ppublish
SO  - Wien Klin Wochenschr. 2010 May;122 Suppl 2:68-73. doi: 10.1007/s00508-010-1335-z.


PMID- 20533587
OWN - NLM
STAT- MEDLINE
DCOM- 20110307
LR  - 20150220
IS  - 1553-5606 (Electronic)
IS  - 1553-5592 (Linking)
VI  - 5
IP  - 5
DP  - 2010 May-Jun
TI  - Postcards from our students--reflections on professionalism and ethics.
PG  - E10-3
LID - 10.1002/jhm.712 [doi]
FAU - Neely, David
AU  - Neely D
AD  - Department of Medicine, Northwestern University Feinberg School of Medicine,
      Chicago, Illinois, USA. dneely@nmh.org
FAU - Szmuilowicz, Eytan
AU  - Szmuilowicz E
FAU - Neely, Kathy
AU  - Neely K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Hosp Med
JT  - Journal of hospital medicine
JID - 101271025
SB  - IM
RPI - J Hosp Med. 2010 Oct;5(8):496-9. PMID: 20945476
MH  - Clinical Competence/standards
MH  - Humans
MH  - Internship and Residency/*ethics/standards
MH  - *Students, Medical
EDAT- 2010/06/10 06:00
MHDA- 2011/03/08 06:00
CRDT- 2010/06/10 06:00
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2011/03/08 06:00 [medline]
AID - 10.1002/jhm.712 [doi]
PST - ppublish
SO  - J Hosp Med. 2010 May-Jun;5(5):E10-3. doi: 10.1002/jhm.712.


PMID- 20533567
OWN - NLM
STAT- MEDLINE
DCOM- 20100913
LR  - 20100616
IS  - 1549-4918 (Electronic)
IS  - 1066-5099 (Linking)
VI  - 28
IP  - 6
DP  - 2010 Jun
TI  - European scientific, ethical, and legal issues on human stem cell research and
      regenerative medicine.
PG  - 1005-7
LID - 10.1002/stem.436 [doi]
FAU - Hovatta, Outi
AU  - Hovatta O
FAU - Stojkovic, Miodrag
AU  - Stojkovic M
FAU - Nogueira, Maria
AU  - Nogueira M
FAU - Varela-Nieto, Isabel
AU  - Varela-Nieto I
LA  - eng
PT  - Editorial
PL  - England
TA  - Stem Cells
JT  - Stem cells (Dayton, Ohio)
JID - 9304532
SB  - IM
MH  - Animals
MH  - *Bioethical Issues
MH  - Europe
MH  - Humans
MH  - Regenerative Medicine/*legislation & jurisprudence
MH  - Research Design/*legislation & jurisprudence
MH  - *Stem Cells
EDAT- 2010/06/10 06:00
MHDA- 2010/09/14 06:00
CRDT- 2010/06/10 06:00
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2010/09/14 06:00 [medline]
AID - 10.1002/stem.436 [doi]
PST - ppublish
SO  - Stem Cells. 2010 Jun;28(6):1005-7. doi: 10.1002/stem.436.


PMID- 20533556
OWN - NLM
STAT- MEDLINE
DCOM- 20110331
LR  - 20101214
IS  - 1520-6017 (Electronic)
IS  - 0022-3549 (Linking)
VI  - 100
IP  - 1
DP  - 2011 Jan
TI  - A review of three-dimensional in vitro tissue models for drug discovery and
      transport studies.
PG  - 59-74
LID - 10.1002/jps.22257 [doi]
AB  - The use of animal models in drug discovery studies presents issues with
      feasibility and ethical concerns. To address these limitations, in vitro tissue
      models have been developed to provide a means for systematic, repetitive, and
      quantitative investigation of drugs. By eliminating or reducing the need for
      animal subjects, these models can serve as platforms for more tightly controlled,
      high-throughput screening of drugs and for pharmacokinetic and pharmacodynamic
      analyses of drugs. The focus of this review is three-dimensional (3D) tissue
      models that can capture cell-cell and cell-matrix interactions. Compared to the
      2D culture of cell monolayers, 3D models more closely mimic native tissues since 
      the cellular microenvironment established in the 3D models often plays a
      significant role in disease progression and cellular responses to drugs. A
      growing body of research has been published in the literature, which highlights
      the benefits of the 3D in vitro models of various tissues. This review provides
      an overview of some successful 3D in vitro models that have been developed to
      mimic liver, breast, cardiac, muscle, bone, and corneal tissues as well as
      malignant tissues in solid tumors.
CI  - Copyright (c) 2010 Wiley-Liss, Inc. and the American Pharmacists Association
FAU - Elliott, Nelita T
AU  - Elliott NT
AD  - Department of Biomedical Engineering, Duke University, 136 Hudson Hall, PO Box
      90281, Durham, North Carolina 27708, USA.
FAU - Yuan, Fan
AU  - Yuan F
LA  - eng
GR  - CA123714/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20100608
PL  - United States
TA  - J Pharm Sci
JT  - Journal of pharmaceutical sciences
JID - 2985195R
RN  - 0 (Drugs, Investigational)
SB  - IM
MH  - *Animal Testing Alternatives/trends
MH  - Animals
MH  - Biological Transport
MH  - Cell Communication/drug effects
MH  - Cell-Matrix Junctions/drug effects
MH  - Cells, Cultured
MH  - Culture Techniques
MH  - Drug Discovery/*methods
MH  - Drugs, Investigational/*pharmacokinetics/pharmacology
MH  - High-Throughput Screening Assays
MH  - Humans
MH  - Microfluidics/methods
MH  - Spheroids, Cellular
MH  - Tumor Cells, Cultured
EDAT- 2010/06/10 06:00
MHDA- 2011/04/01 06:00
CRDT- 2010/06/10 06:00
PHST- 2009/12/15 00:00 [received]
PHST- 2010/05/04 00:00 [accepted]
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2011/04/01 06:00 [medline]
AID - 10.1002/jps.22257 [doi]
AID - S0022-3549(15)32337-6 [pii]
PST - ppublish
SO  - J Pharm Sci. 2011 Jan;100(1):59-74. doi: 10.1002/jps.22257. Epub 2010 Jun 8.


PMID- 20532723
OWN - NLM
STAT- MEDLINE
DCOM- 20101012
LR  - 20220311
IS  - 1496-8975 (Electronic)
IS  - 0832-610X (Linking)
VI  - 57
IP  - 8
DP  - 2010 Aug
TI  - Intravenous lidocaine does not reduce length of hospital stay following abdominal
      hysterectomy.
PG  - 759-66
LID - 10.1007/s12630-010-9332-2 [doi]
AB  - PURPOSE: Intravenous lidocaine given both intraoperatively and postoperatively
      decreases pain scores, reduces opioid consumption, and promotes faster return of 
      bowel function following abdominal surgery. The purpose of this trial was to
      determine if intravenous lidocaine limited to the intraoperative period reduces
      length of hospital stay and improves functional recovery following abdominal
      hysterectomy. METHODS: Following Research Ethics Board approval and informed
      consent, women of American Society of Anesthesiologists' class I and II
      undergoing abdominal hysterectomy were assigned randomly to lidocaine and control
      groups. Lidocaine subjects received an intravenous bolus of 1.5 mg.kg(-1)
      followed by an infusion of 3 mg.kg(-1).hr(-1), while control subjects received
      matching placebo. Patients, anesthesiologists, and study personnel were blinded, 
      and anesthesia and multimodal perioperative analgesia were standardized. The
      primary outcome of this trial was discharge from hospital on or before the second
      postoperative day (POD2). Additional criteria were assessed for secondary
      outcomes, i.e., discharge fitness on POD2, length of hospital stay, opioid use,
      numeric rating scores for pain, quality of recovery, and recovery of bowel
      function. RESULTS: Ninety of the 93 women who were recruited completed the study 
      protocol. The characteristics of the patients in both groups were
      similar-lidocaine group (n = 44) and control group (n = 46)-and no difference was
      noted between groups in the numbers of women discharged from hospital on POD2 (10
      lidocaine, 15 control; P = 0.295). Days to discharge fitness (P = 0.666) and
      length of hospital stay (P = 0.456) were also similar. Differences in opioid
      consumption, pain scores, and recovery were neither clinically nor statistically 
      significant. CONCLUSION: Intraoperative administration of intravenous lidocaine
      did not reduce hospital stay or improve objective measures of analgesia and
      recovery following abdominal hysterectomy. This trial was registered at
      ClinicalTrials.gov (NCT00382499).
FAU - Bryson, Gregory L
AU  - Bryson GL
AD  - Department of Anesthesiology, The Ottawa Hospital - Civic Campus, Ottawa, ON,
      Canada. glbryson@ottawahospital.on.ca
FAU - Charapov, Ilia
AU  - Charapov I
FAU - Krolczyk, Gregory
AU  - Krolczyk G
FAU - Taljaard, Monica
AU  - Taljaard M
FAU - Reid, Dennis
AU  - Reid D
LA  - eng
SI  - ClinicalTrials.gov/NCT00382499
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20100608
PL  - United States
TA  - Can J Anaesth
JT  - Canadian journal of anaesthesia = Journal canadien d'anesthesie
JID - 8701709
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Anesthetics, Local)
RN  - 76I7G6D29C (Morphine)
RN  - 98PI200987 (Lidocaine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Analgesics, Opioid/administration & dosage/therapeutic use
MH  - Anesthesia, General
MH  - Anesthetics, Local/administration & dosage/*therapeutic use
MH  - Consciousness Monitors
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - *Hysterectomy
MH  - Infusions, Intravenous
MH  - Injections, Intravenous
MH  - Length of Stay
MH  - Lidocaine/administration & dosage/*therapeutic use
MH  - Middle Aged
MH  - Morphine/administration & dosage/therapeutic use
MH  - Pain, Postoperative/drug therapy
MH  - *Postoperative Care
MH  - Treatment Outcome
EDAT- 2010/06/10 06:00
MHDA- 2010/10/13 06:00
CRDT- 2010/06/10 06:00
PHST- 2010/01/29 00:00 [received]
PHST- 2010/05/10 00:00 [accepted]
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2010/10/13 06:00 [medline]
AID - 10.1007/s12630-010-9332-2 [doi]
PST - ppublish
SO  - Can J Anaesth. 2010 Aug;57(8):759-66. doi: 10.1007/s12630-010-9332-2. Epub 2010
      Jun 8.


PMID- 20532667
OWN - NLM
STAT- MEDLINE
DCOM- 20120330
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 17
IP  - 3
DP  - 2011 Sep
TI  - Intrinsic ethics regarding integrated assessment models for climate management.
PG  - 503-23
LID - 10.1007/s11948-010-9209-3 [doi]
AB  - In this essay we develop and argue for the adoption of a more comprehensive model
      of research ethics than is included within current conceptions of responsible
      conduct of research (RCR). We argue that our model, which we label the ethical
      dimensions of scientific research (EDSR), is a more comprehensive approach to
      encouraging ethically responsible scientific research compared to the currently
      typically adopted approach in RCR training. This essay focuses on developing a
      pedagogical approach that enables scientists to better understand and appreciate 
      one important component of this model, what we call intrinsic ethics. Intrinsic
      ethical issues arise when values and ethical assumptions are embedded within
      scientific findings and analytical methods. Through a close examination of a case
      study and its application in teaching, namely, evaluation of climate change
      integrated assessment models, this paper develops a method and case for including
      intrinsic ethics within research ethics training to provide scientists with a
      comprehensive understanding and appreciation of the critical role of values and
      ethical choices in the production of research outcomes.
FAU - Schienke, Erich W
AU  - Schienke EW
AD  - Science, Technology, and Society Program, The Pennsylvania State University, 124 
      Willard Building, University Park, PA 16802, USA. erich@psu.edu
FAU - Baum, Seth D
AU  - Baum SD
FAU - Tuana, Nancy
AU  - Tuana N
FAU - Davis, Kenneth J
AU  - Davis KJ
FAU - Keller, Klaus
AU  - Keller K
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20100608
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Climate Change
MH  - Environmental Monitoring
MH  - Ethics, Research/*education
MH  - Humans
MH  - Science/education/*ethics
MH  - *Social Responsibility
MH  - *Social Values
MH  - Teaching/ethics/*methods
EDAT- 2010/06/10 06:00
MHDA- 2012/03/31 06:00
CRDT- 2010/06/10 06:00
PHST- 2010/02/12 00:00 [received]
PHST- 2010/05/17 00:00 [accepted]
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2012/03/31 06:00 [medline]
AID - 10.1007/s11948-010-9209-3 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2011 Sep;17(3):503-23. doi: 10.1007/s11948-010-9209-3. Epub 2010 
      Jun 8.


PMID- 20532615
OWN - NLM
STAT- MEDLINE
DCOM- 20101130
LR  - 20100816
IS  - 1573-2770 (Electronic)
IS  - 0091-0562 (Linking)
VI  - 46
IP  - 1-2
DP  - 2010 Sep
TI  - Children as research collaborators: issues and reflections from a mobility study 
      in sub-Saharan Africa.
PG  - 215-27
LID - 10.1007/s10464-010-9317-x [doi]
AB  - This paper reflects on issues raised by work with children in an ongoing child
      mobility study in three sub-Saharan African countries: Ghana, Malawi and South
      Africa. There are now 70 school pupils of varying ages involved in the project,
      but the paper is particularly concerned with the participation of those children 
      14 years and under. We examine the significant ethical issues associated with
      working with younger child researchers, and linked questions concerning the
      spaces open to them in African contexts where local cultural constructions of
      childhood and associated economic imperatives (which commonly drive family and
      household endeavour) help shape the attitudes of adults to children's rights and 
      responsibilities and inter-generational power relations.
FAU - Porter, Gina
AU  - Porter G
AD  - Department of Anthropoloogy, Durham University, Science Site, South Road, Durham,
      UK. r.e.porter@durham.ac.uk
FAU - Hampshire, Kate
AU  - Hampshire K
FAU - Bourdillon, Michael
AU  - Bourdillon M
FAU - Robson, Elsbeth
AU  - Robson E
FAU - Munthali, Alister
AU  - Munthali A
FAU - Abane, Albert
AU  - Abane A
FAU - Mashiri, Mac
AU  - Mashiri M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Am J Community Psychol
JT  - American journal of community psychology
JID - 0364535
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Child
MH  - *Community-Based Participatory Research/ethics/methods/organization &
      administration
MH  - Culture
MH  - Developing Countries
MH  - Female
MH  - Ghana
MH  - Humans
MH  - Intergenerational Relations
MH  - Malawi
MH  - Male
MH  - Research Design
MH  - Sex Factors
MH  - Social Class
MH  - *Social Mobility
MH  - Social Support
MH  - Socioeconomic Factors
MH  - South Africa
EDAT- 2010/06/10 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/06/10 06:00
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1007/s10464-010-9317-x [doi]
PST - ppublish
SO  - Am J Community Psychol. 2010 Sep;46(1-2):215-27. doi: 10.1007/s10464-010-9317-x.


PMID- 20532591
OWN - NLM
STAT- MEDLINE
DCOM- 20101210
LR  - 20211020
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 22
IP  - 2
DP  - 2010 Jun
TI  - We meant no harm, yet we made a mistake; why not apologize for it? A student's
      view.
PG  - 159-69
LID - 10.1007/s10730-010-9131-8 [doi]
AB  - This essay explores the unique perspective of medical students regarding the
      ethical challenges of providing full disclosure to patients and their families
      when medical mistakes are made, especially when such mistakes lead to tragic
      outcomes. This narrative underscores core precepts of the healing profession,
      challenging the health care team to be open and truthful, even when doing so is
      uncomfortable. This account also reminds us that nonabandonment is an obligation 
      that assumes accountability for one's actions in the healing relationship and
      that apologizing for mistakes can serve to heal. It argues that even medical
      students have an obligation to speak up when actions violate their moral beliefs,
      even if this means confronting a superior. Ethical principles cannot be abandoned
      in fear of adverse evaluation or failure to conform. Healthcare workers have an
      obligation to address mistakes made around the time of a patient's death with the
      patient's family. This responsibility trumps any selfish desire to avoid
      unpleasant feelings of guilt or regret. Such events often bring closure to
      already anguished relatives and spouses, and may help to facilitate the grieving 
      process. This includes pressing forward the need to apologize to patients and/or 
      their families when mistakes are made and when decisions are made that lead to
      poor outcomes for the patient, even when benevolently intended.
FAU - Sanford, Dominic E
AU  - Sanford DE
AD  - MU Center for Health Ethics, University of Missouri School of Medicine, CE724-1
      Hospital Drive, Columbia, MO 65212, USA.
FAU - Fleming, David A
AU  - Fleming DA
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - Clinical Clerkship
MH  - Ethics, Medical/education
MH  - Humans
MH  - Lung Neoplasms/therapy
MH  - Male
MH  - *Medical Errors
MH  - Middle Aged
MH  - Professional-Patient Relations/*ethics
MH  - Resuscitation Orders
MH  - Truth Disclosure/*ethics
MH  - United States
EDAT- 2010/06/10 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/06/10 06:00
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1007/s10730-010-9131-8 [doi]
PST - ppublish
SO  - HEC Forum. 2010 Jun;22(2):159-69. doi: 10.1007/s10730-010-9131-8.


PMID- 20532582
OWN - NLM
STAT- MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1435-604X (Electronic)
IS  - 0268-8921 (Linking)
VI  - 26
IP  - 4
DP  - 2011 Jul
TI  - Influence of the parameters of the Er:YAG laser on the apical sealing of
      apicectomized teeth.
PG  - 433-8
LID - 10.1007/s10103-010-0792-y [doi]
AB  - Failures in the sealing of the tooth apex have been considered to be responsible 
      for most of the failures of apical surgeries. The Er:YAG laser has been proposed 
      as an alternative for the use of rotator instruments in surgical endodontics due 
      to its precision, lack of vibration, less post-operative discomfort, bacterial
      reduction, and less stress for patients and professionals. Following approval by 
      the ethics committee, 12 extracted human canines without previous endodontic
      treatment with anatomically normal roots and free from apical lesions were washed
      in running tap water and disinfected. The teeth were sectioned axially at the
      crown-root junction and submitted to routine endodontic treatment. The apical
      limit was set at 1 mm before the apical foramen. The root canals were routinely
      filled with Gutta-Percha points and Sealer 26 and were randomly distributed into 
      two groups (n = 6). In group I, apicectomy was performed with the Er:YAG laser
      (KAVO KEY Laser II(R), Germany, lambda = 2.940 nm, pulsed mode, 2051 tip, with
      air spray cooling, 250 mJ/15 Hz). Apical cut was performed of perpendicular mode 
      3 mm from the apical foramen. In group II, the same procedures and the same
      sequence as above was used, varying only the parameters of the Er:YAG laser (400 
      mJ/6 Hz). Sealing of the cervical end the apex was carried out with acrylic
      resin; the roots were covered by a layer of epoxy glue and two layers of nail
      polish. The specimens were divided into groups and fixed, by the cervical third, 
      on wax. Impermeabilization of the residual root apical third was performed
      following the same procedures used in the cervical third but the residual apex
      was left free from the impermeabilization. After that, the roots were immersed in
      a 2% methylene blue solution and placed in a bacteriological oven for 48 h and
      then washed in running tap water for 2 h. The samples were sagittally split into 
      two parts. The segments were visually observed and the one showing the greatest
      level of dye leakage was selected and kept in an individual container and coded
      accordingly. Apical staining was measured using a stereoscopic magnifying glass, 
      a compass, and a caliper. The measurement was performed by three endodontists,
      previously calibrated, and unaware of the sample coding. The results showed that 
      group I showed the greatest level of dye leakage. There was a significantly
      difference between the groups (p = 0.001). It is concluded that the apicectomies 
      carried out with 400 mJ/6 Hz showed the smallest infiltration value.
FAU - Marques, Aparecida Maria Cordeiro
AU  - Marques AM
AD  - Center of Biophotonics, School of Dentistry, Federal University of Bahia, Av.
      Araujo Pinho, 62, Canela, Salvador, BA, CEP 40110-150, Brazil.
FAU - Gerbi, Marleny Elizabeth M M
AU  - Gerbi ME
FAU - dos Santos, Jean Nunes
AU  - dos Santos JN
FAU - Noia, Manuela Pimentel
AU  - Noia MP
FAU - Oliveira, Priscila Chagas
AU  - Oliveira PC
FAU - Brugnera Junior, Aldo
AU  - Brugnera Junior A
FAU - Zanin, Fatima Antonia Aparecida
AU  - Zanin FA
FAU - Pinheiro, Antonio Luiz Barbosa
AU  - Pinheiro AL
LA  - eng
PT  - Journal Article
DEP - 20100608
PL  - England
TA  - Lasers Med Sci
JT  - Lasers in medical science
JID - 8611515
SB  - IM
MH  - Apicoectomy/*instrumentation/methods
MH  - Dental Leakage/prevention & control/*surgery
MH  - Dentistry/methods
MH  - Endodontics/instrumentation/methods
MH  - Feasibility Studies
MH  - Humans
MH  - Lasers, Solid-State/*therapeutic use
MH  - Statistics, Nonparametric
EDAT- 2010/06/10 06:00
MHDA- 2011/11/11 06:00
CRDT- 2010/06/10 06:00
PHST- 2009/03/12 00:00 [received]
PHST- 2010/04/26 00:00 [accepted]
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2011/11/11 06:00 [medline]
AID - 10.1007/s10103-010-0792-y [doi]
PST - ppublish
SO  - Lasers Med Sci. 2011 Jul;26(4):433-8. doi: 10.1007/s10103-010-0792-y. Epub 2010
      Jun 8.


PMID- 20532154
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1555-5194 (Electronic)
IS  - 1550-5952 (Linking)
VI  - 7
IP  - 5
DP  - 2010 May
TI  - Core ethical questions: what do you do when your obligations as a psychiatrist
      conflict with ethics?
PG  - 19-26
AB  - Psychiatrists face many difficult ethical decisions in which they must exercise
      their discretion. In the most difficult decisions they confront, there are
      significant "harms," regardless of what they choose. The best they can do in
      these instance is to be as acutely aware of the most important pros and cons as
      they can. This article will discuss such pros and cons in regard to,
      particularly, informing patients when they may be dangerous to themselves or
      others, have dementia, and have genetic illness. This article will also discuss
      giving moral weight to the psychiatrist's own interests when making these ethical
      decisions.
FAU - Howe, Edmund
AU  - Howe E
AD  - Dr. Howe is Professor, Department of Psychiatry, Director, Programs in Medical
      Ethics, and Senior Scientist, Center for the Study of Traumatic Stress, Uniformed
      Services University of the Health Sciences, Bethesda, Maryland.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Psychiatry (Edgmont)
JT  - Psychiatry (Edgmont (Pa. : Township))
JID - 101484252
PMC - PMC2882279
OTO - NOTNLM
OT  - Informing patients
OT  - child abuse
OT  - dangerousness
OT  - dementia
OT  - genetics
OT  - reporting
OT  - suicide
OT  - unprofessional conduct
OT  - warning
EDAT- 2010/06/10 06:00
MHDA- 2010/06/10 06:01
CRDT- 2010/06/10 06:00
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2010/06/10 06:01 [medline]
PST - ppublish
SO  - Psychiatry (Edgmont). 2010 May;7(5):19-26.


PMID- 20530994
OWN - NLM
STAT- MEDLINE
DCOM- 20110307
LR  - 20191111
IS  - 1910-622X (Print)
IS  - 1910-622X (Linking)
VI  - 23
IP  - 2
DP  - 2010 May
TI  - A conceptual framework for advanced practice nursing in a pediatric tertiary care
      setting: the SickKids' experience.
PG  - 32-46
AB  - Advanced practice nurses (APNs) at The Hospital for Sick Children (SickKids) are 
      pediatric healthcare providers who integrate principles and theories of advanced 
      nursing with specialty knowledge to provide autonomous, independent, accountable,
      ethical and developmentally appropriate care in complex, often ambiguous and
      rapidly changing healthcare environments. Caring for children and adolescents
      requires culturally sensitive and family-centred approaches to care that
      incorporate a unique body of knowledge. Family-centred care is an approach to
      planning, delivery and evaluation of healthcare that is governed by the
      establishment of mutually beneficial partnerships among APNs, health
      professionals and children/families. The cornerstone of APN practice at SickKids 
      is the recognition of "family" as the recipients of care. By valuing and
      developing relationships with families, APNs promote excellence in healthcare
      across the care continuum to optimize the child's and family's physical,
      emotional, social, psychological and spiritual well-being. This paper outlines
      the evolution of advanced practice nursing at SickKids, beginning with the
      introduction of APN roles in the 1970s and culminating in the current critical
      mass of APNs who have been integrated throughout the hospital's infrastructure.
      We describe the process used to create a common vision and a framework to guide
      pediatric advanced nursing practice.
FAU - LeGrow, Karen
AU  - LeGrow K
AD  - Centre for Nursing, Hospital for Sick Children, Lawrence S. Bloomberg Faculty of 
      Nursing, University of Toronto, Toronto, ON.
FAU - Hubley, Pam
AU  - Hubley P
FAU - McAllister, Mary
AU  - McAllister M
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Nurs Leadersh (Tor Ont)
JT  - Nursing leadership (Toronto, Ont.)
JID - 101470760
MH  - Advanced Practice Nursing/*methods
MH  - Child
MH  - Child Welfare
MH  - Clinical Competence
MH  - *Concept Formation
MH  - Cooperative Behavior
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Leadership
MH  - Mentors
MH  - Nurse Administrators
MH  - Nursing Theory
MH  - Ontario
MH  - Pediatric Nursing/*methods/organization & administration
MH  - Philosophy, Nursing
EDAT- 2010/06/10 06:00
MHDA- 2011/03/08 06:00
CRDT- 2010/06/10 06:00
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2011/03/08 06:00 [medline]
AID - 10.12927/cjnl.2013.21831 [doi]
PST - ppublish
SO  - Nurs Leadersh (Tor Ont). 2010 May;23(2):32-46. doi: 10.12927/cjnl.2013.21831.


PMID- 20530166
OWN - NLM
STAT- MEDLINE
DCOM- 20101101
LR  - 20211020
IS  - 1488-2329 (Electronic)
IS  - 0820-3946 (Linking)
VI  - 182
IP  - 14
DP  - 2010 Oct 5
TI  - A framework for research ethics review during public emergencies.
PG  - 1533-7
LID - 10.1503/cmaj.090976 [doi]
FAU - Tansey, Catherine M
AU  - Tansey CM
AD  - Joint Centre for Bioethics, University of Toronto, Toronto, Ont.
      catherine.tansey@utoronto.ca
FAU - Herridge, Margaret S
AU  - Herridge MS
FAU - Heslegrave, Ronald J
AU  - Heslegrave RJ
FAU - Lavery, James V
AU  - Lavery JV
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100607
PL  - Canada
TA  - CMAJ
JT  - CMAJ : Canadian Medical Association journal = journal de l'Association medicale
      canadienne
JID - 9711805
SB  - IM
MH  - Codes of Ethics
MH  - Crisis Intervention
MH  - Disasters
MH  - Disease Outbreaks
MH  - *Emergencies
MH  - *Ethics, Research
MH  - Humans
MH  - Terrorism
MH  - Time Factors
PMC - PMC2950185
EDAT- 2010/06/10 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/06/10 06:00
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - cmaj.090976 [pii]
AID - 10.1503/cmaj.090976 [doi]
PST - ppublish
SO  - CMAJ. 2010 Oct 5;182(14):1533-7. doi: 10.1503/cmaj.090976. Epub 2010 Jun 7.


PMID- 20530091
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20101118
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 6
DP  - 2010 Jun
TI  - Caster Semenya: sport, categories and the creative role of ethics.
PG  - 378-9
LID - 10.1136/jme.2010.035634 [doi]
AB  - Caster Semenya, a South African 18-year-old, won the 800-metre track running
      title at the Berlin World Athletics Championships in 2009. Only 3 h later, her
      gender was being harshly contested. The investigation of the International
      Association of Athletics Federations (IAAF) was neither discreet nor respectful
      of her privacy. Caster's case has implications for the ethics of sports and
      debates about gender and enhancement, and for the philosophical debate about the 
      nature of categories and the classification of people. The IAAF has not disclosed
      the results of their tests on Caster, and the South African Ministry of Sport has
      decreed that in any case she can continue running with women in her own country. 
      But could a scientific or medical test offer uncontroversial answers regarding
      Caster's gender? The concept of 'gender' is partly a social construction. The
      authors argue that ethics may guide science and medicine at addressing such
      questions.
FAU - Camporesi, Silvia
AU  - Camporesi S
AD  - Life Sciences: Foundations & Ethics PhD Program, European School of Molecular
      Medicine and University of Milan, Milan, Italy.
      silvia.camporesi@ifom-ieo-campus.it
FAU - Maugeri, Paolo
AU  - Maugeri P
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Disorders of Sex Development/diagnosis
MH  - Female
MH  - Humans
MH  - Male
MH  - Prejudice
MH  - *Sex Characteristics
MH  - Track and Field/*ethics
EDAT- 2010/06/10 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/06/10 06:00
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - 36/6/378 [pii]
AID - 10.1136/jme.2010.035634 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Jun;36(6):378-9. doi: 10.1136/jme.2010.035634.


PMID- 20530090
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20100610
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 6
DP  - 2010 Jun
TI  - Therapeutic privilege: between the ethics of lying and the practice of truth.
PG  - 353-7
LID - 10.1136/jme.2009.033340 [doi]
AB  - The 'right to the truth' involves disclosing all the pertinent facts to a patient
      so that an informed decision can be made. However, this concept of a 'right to
      the truth' entails certain ambiguities, especially since it is difficult to apply
      the concept in medical practice based mainly on current evidence-based data that 
      are probabilistic in nature. Furthermore, in some situations, the doctor is
      confronted with a moral dilemma, caught between the necessity to inform the
      patient (principle of autonomy) and the desire to ensure the patient's well-being
      by minimising suffering (principle of beneficence). To comply with the principle 
      of beneficence as well as the principle of non-maleficence 'to do no harm', the
      doctor may then feel obliged to turn to 'therapeutic privilege', using lies or
      deception to preserve the patient's hope, and psychological and moral integrity, 
      as well as his self-image and dignity. There is no easy answer to such a moral
      dilemma. This article will propose a process that can fit into reflective
      practice, allowing the doctor to decide if the use of therapeutic privilege is
      justified when he is faced with these kinds of conflicting circumstances. We will
      present the conflict arising in practice in the context of the various
      theoretical orientations in ethics, and then we will suggest an approach for a
      'practice of truth'. Last, we will situate this reflective method in the broader 
      clinical context of medical practice viewed as a dialogic process.
FAU - Richard, Claude
AU  - Richard C
AD  - Primary Care Research Team, Centre de sante et de services sociaux de Laval,
      Hopital Cite-de-la-Sante, Laval, Quebec, Canada. ell4400@videotron.ca
FAU - Lajeunesse, Yvette
AU  - Lajeunesse Y
FAU - Lussier, Marie-Therese
AU  - Lussier MT
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Deception
MH  - Decision Making/*ethics
MH  - *Ethics, Medical
MH  - Humans
MH  - Patient Rights
MH  - *Physician's Role
MH  - *Professional Autonomy
MH  - Truth Disclosure
EDAT- 2010/06/10 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/06/10 06:00
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - 36/6/353 [pii]
AID - 10.1136/jme.2009.033340 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Jun;36(6):353-7. doi: 10.1136/jme.2009.033340.


PMID- 20530088
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20100610
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 6
DP  - 2010 Jun
TI  - Ethical quandaries posing as conflicts of interest.
PG  - 328-32
LID - 10.1136/jme.2009.034710 [doi]
AB  - Conflicts of interest are receiving increased attention in medical research,
      clinical practice and education. Criticism of, and penalties for, conflicts of
      interest have been insufficiently discussed and have been applied without
      adequate conceptual backing. Genuine conflicts of interest are situations in
      which alternative courses of action are ethically equivalent, decision-making
      being less a matter of moral deliberation than of personal weighing of interest. 
      In contrast, situations usually thought of as conflicts of interest are mostly
      temptations to follow an attractive but undue option that causes harm by failing 
      to uphold well-entrenched ethical standards. Examples of moral quandaries that
      pose as ethically neutral conflicts of interest are healthcare providers enticed 
      to favour certain products; patients being referred to non-therapeutic trials
      entailing risks and non-optimal healthcare; industry-supported scientists failing
      to deliver unbiased research results and reports or participating in
      ghost-writing; and sponsored educators who praise their supporters beyond
      objective evidence. All these are moral blemishes, where integrity gives way to
      material incentives at the cost of provoking risky and harm-producing situations,
      thus constituting false conflicts of interest when they are in fact ethical
      misdemeanours. Disclosure has been the most widely recommended response to avoid 
      the concealment of conflicting and ethically suspect interests. Regulations
      regarding disclosure reveal a utilitarian stance that shows more concern for the 
      magnitude of support or sponsorship than for the underlying ethical
      transgression. Education and oversight should directly address and help correct
      the moral attitude towards undue influence of inducements and marketing
      strategies falsely posing as conflicts of interest.
FAU - Kottow, Miguel
AU  - Kottow M
AD  - School of Public Health, Universidad de Chile, Universidad Diego Portales,
      Casilla 16168 Correo 10, Santiago, Chile. mkottow@gmail.com
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Bioethical Issues
MH  - *Conflict of Interest
MH  - Decision Making, Organizational
MH  - Delivery of Health Care/*ethics/organization & administration
MH  - *Ethics, Medical
MH  - *Ethics, Research
MH  - Humans
MH  - Moral Obligations
EDAT- 2010/06/10 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/06/10 06:00
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - 36/6/328 [pii]
AID - 10.1136/jme.2009.034710 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Jun;36(6):328-32. doi: 10.1136/jme.2009.034710.


PMID- 20530086
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20211028
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 6
DP  - 2010 Jun
TI  - '(More) trials and tribulations': the effect of the EU directive on clinical
      trials in intensive care and emergency medicine, five years after its
      implementation.
PG  - 322-5
LID - 10.1136/jme.2009.035261 [doi]
AB  - The European Clinical Trials Directive was issued in 2001 and aimed to simplify
      and harmonise the regulatory framework of clinical trials throughout Europe, thus
      stimulating European research. However, significant complexity and inconsistency 
      remains due to disparate interpretation by EU member states. Critical care
      research has been particularly impacted due to variable and often restrictive
      consenting procedures for incapacitated subjects, with some countries requiring a
      court-appointed representative, while others recognise consent from family
      members and occasionally professional representatives. Furthermore, the absence
      of a waiver of consent threatened to put an end to emergency research in Europe
      and was met with varied responses. Approval procedures by ethics committees are
      equally inconsistent, particularly those relating to provision of a single
      opinion for multi-centre trials. Although evidence is somewhat mixed, this
      complexity as well as a general increase in administrative and financial burden
      following the Directive has been shown to cause a reduction in clinical trial
      activity in Europe, particularly academic trials. We aim to clarify some of these
      inconsistent procedures, particularly those relating to informed consent of
      incapacitated subjects, as well as discussing some general weaknesses and
      possible improvements of the Directive ahead of its planned revision in 2011.
FAU - Robinson, Katy
AU  - Robinson K
AD  - College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, 
      UK.
FAU - Andrews, Peter J D
AU  - Andrews PJ
LA  - eng
GR  - G0401633/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Clinical Trials as Topic/*ethics/*legislation & jurisprudence/methods
MH  - *Critical Care
MH  - *Emergency Medicine
MH  - Ethics Committees, Research
MH  - Europe
MH  - European Union/organization & administration
MH  - Humans
MH  - Informed Consent/*ethics
EDAT- 2010/06/10 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/06/10 06:00
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - 36/6/322 [pii]
AID - 10.1136/jme.2009.035261 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Jun;36(6):322-5. doi: 10.1136/jme.2009.035261.


PMID- 20529989
OWN - NLM
STAT- MEDLINE
DCOM- 20100924
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 256
IP  - 2
DP  - 2010 Aug
TI  - Nonalcoholic fatty liver disease: US-based acoustic radiation force impulse
      elastography.
PG  - 640-7
LID - 10.1148/radiol.10091662 [doi]
AB  - PURPOSE: To investigate the clinical usefulness of ultrasonography-based acoustic
      radiation force impulse (ARFI) elastography (ie, ARFI sonoelastography) in
      patients with a diagnosis of nonalcoholic fatty liver disease (NAFLD) and compare
      ARFI sonoelastography results with transient sonoelastography and serum fibrosis 
      marker test results. MATERIALS AND METHODS: Written informed consent was obtained
      from all subjects, and the local ethics committee approved the study. Fifty-four 
      patients with a liver biopsy-confirmed diagnosis of NAFLD (mean age, 50.6 years
      +/- 13.7) were examined. All patients with NAFLD and healthy volunteers underwent
      ARFI sonoelastography, transient sonoelastography, and serum liver fibrosis
      marker testing (hyaluronic acids, type IV collagen 7 S domain). Ten healthy
      volunteers underwent ARFI sonoelastography. ARFI sonoelastography results were
      compared with liver biopsy findings, the reference standard. ARFI
      sonoelastography findings were compared with liver biopsy, transient
      sonoelastography, and serum fibrosis marker test results. Student t testing was
      used for univariate comparisons; Kruskal-Wallis testing, for assessments
      involving more than two independent groups; and areas under the receiver
      operating characteristic curve (A(z)), to assess the sensitivity and specificity 
      of ARFI sonoelastography for detection of stage 3 and stage 4 fibrosis. RESULTS: 
      Median velocities in the patients with NAFLD were 1.040 m/sec for those with
      stage 0 fibrosis, 1.120 m/sec for those with stage 1, 1.130 m/sec for those with 
      stage 2, 1.780 m/sec for those with stage 3, and 2.180 m/sec for those with stage
      4. The A(z) for the diagnosis of hepatic fibrosis stages 3 or higher was 0.973
      (optimal cutoff value, 1.77 m/sec; sensitivity, 100%; specificity, 91%), while
      that for the diagnosis of stage 4 fibrosis was 0.976 (optimal cutoff value, 1.90 
      m/sec; sensitivity, 100%; specificity, 96%). Significant correlations between
      median velocity measured by using ARFI sonoelastography and the following
      parameters were observed: liver stiffness measured with transient
      sonoelastography (r = 0.75, P < .0001), serum level of hyaluronic acid(r = 0.459,
      P = .0009), and serum level of type IV collagen 7 S domain (r = 0.445, P =
      .0015). CONCLUSION: There is a significant positive correlation between median
      velocity measured by using ARFI sonoelastography and severity of liver fibrosis
      in patients with NAFLD. The results of ARFI sonoelastography were similar to
      those of transient sonoelastography.
FAU - Yoneda, Masato
AU  - Yoneda M
AD  - Division of Gastroenterology, Yokohama City University Hospital, 3-9 Fuku-ura,
      Kanazawa-ku, Yokohama 236-0004, Japan.
FAU - Suzuki, Kaori
AU  - Suzuki K
FAU - Kato, Shingo
AU  - Kato S
FAU - Fujita, Koji
AU  - Fujita K
FAU - Nozaki, Yuichi
AU  - Nozaki Y
FAU - Hosono, Kunihiro
AU  - Hosono K
FAU - Saito, Satoru
AU  - Saito S
FAU - Nakajima, Atsushi
AU  - Nakajima A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100607
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Elasticity Imaging Techniques/*methods
MH  - Fatty Liver/*diagnostic imaging
MH  - Fatty Liver, Alcoholic/diagnostic imaging
MH  - Female
MH  - Humans
MH  - Image Interpretation, Computer-Assisted/*methods
MH  - Male
MH  - Middle Aged
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
EDAT- 2010/06/10 06:00
MHDA- 2010/09/25 06:00
CRDT- 2010/06/10 06:00
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2010/09/25 06:00 [medline]
AID - radiol.10091662 [pii]
AID - 10.1148/radiol.10091662 [doi]
PST - ppublish
SO  - Radiology. 2010 Aug;256(2):640-7. doi: 10.1148/radiol.10091662. Epub 2010 Jun 7.


PMID- 20529524
OWN - NLM
STAT- MEDLINE
DCOM- 20100706
LR  - 20211020
IS  - 1086-8089 (Print)
IS  - 1086-8089 (Linking)
VI  - 14
IP  - 1
DP  - 2010 Jan-Mar
TI  - Laparoscopic cholecystectomy with Harmonic scalpel.
PG  - 14-9
LID - 10.4293/108680810X12674612014301 [doi]
AB  - BACKGROUND: Laparoscopic cholecystectomy is the "gold standard" in the treatment 
      of symptomatic gallbladder lithiasis. Nevertheless, some pitfalls are associated 
      with the use of the monopolar hook, such as the risk of thermal injuries and
      biliary complications. By contrast, the ultrasonically activated scalpel, ie,
      Harmonic (Ethicon Endo Surgery INC - Johnson & Johnson Medical SPA, Somerville,
      NJ) in laparoscopic cholecystectomies has been increasingly used for dissection
      of the gallbladder and for division of vessels and the cystic duct, because it
      reduces the risk of thermal injuries. METHODS: During a 2-year period, in a
      personal series of 95 consecutive patients, the Harmonic scalpel was used as the 
      sole instrument for both division and dissection of the cystic artery and duct.
      The average length of inpatient stay, procedure duration, and complications were 
      compared with the data of a homogenous control group of patients who were treated
      using monopolar electrosurgery and clips. RESULTS: Neither major complications
      nor bile duct injuries were detected in either group, and no statistically
      significant difference was found between the 2 in terms of the incidence of
      postoperative complications. However, the mean operative time was significantly
      shorter in patients treated with the Harmonic scalpel. CONCLUSION: The Harmonic
      scalpel is not only a safe and effective instrument but also a reliable
      substitute for clips because it provides complete hemobiliary stasis. Even if the
      study revealed no differences with regard to postoperative complications, the
      Harmonic scalpel represents a viable alternative because of the shorter operation
      time and cost savings that are inherent in a procedure using it as a single
      instrument.
FAU - Gelmini, Roberta
AU  - Gelmini R
AD  - Department of Surgery, Policlinico of Modena, University of Modena and Reggio
      Emilia, Italy. roberta.gelmini@unimore.it
FAU - Franzoni, Chiara
AU  - Franzoni C
FAU - Zona, Stefano
AU  - Zona S
FAU - Andreotti, Alessia
AU  - Andreotti A
FAU - Saviano, Massimo
AU  - Saviano M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - JSLS
JT  - JSLS : Journal of the Society of Laparoendoscopic Surgeons
JID - 100884618
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cholecystectomy, Laparoscopic/*instrumentation
MH  - Cholecystitis, Acute/surgery
MH  - Cholecystolithiasis/surgery
MH  - Choledocholithiasis/surgery
MH  - Cholelithiasis/*surgery
MH  - Cystic Duct/surgery
MH  - Equipment Design
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Ultrasonics
MH  - Young Adult
PMC - PMC3021285
EDAT- 2010/06/10 06:00
MHDA- 2010/07/07 06:00
CRDT- 2010/06/10 06:00
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2010/07/07 06:00 [medline]
AID - 10.4293/108680810X12674612014301 [doi]
PST - ppublish
SO  - JSLS. 2010 Jan-Mar;14(1):14-9. doi: 10.4293/108680810X12674612014301.


PMID- 20529367
OWN - NLM
STAT- MEDLINE
DCOM- 20110613
LR  - 20220409
IS  - 1747-5341 (Electronic)
IS  - 1747-5341 (Linking)
VI  - 5
DP  - 2010 Jun 9
TI  - The Infectious Diseases Society of America Lyme guidelines: a cautionary tale
      about the development of clinical practice guidelines.
PG  - 9
LID - 10.1186/1747-5341-5-9 [doi]
AB  - Flawed clinical practice guidelines may compromise patient care. Commercial
      conflicts of interest on panels that write treatment guidelines are particularly 
      problematic, because panelists may have conflicting agendas that influence
      guideline recommendations. Historically, there has been no legal remedy for
      conflicts of interest on guidelines panels. However, in May 2008, the Attorney
      General of Connecticut concluded a ground-breaking antitrust investigation into
      the development of Lyme disease treatment guidelines by one of the largest
      medical societies in the United States, the Infectious Diseases Society of
      America (IDSA). Although the investigation found significant flaws in the IDSA
      guidelines development process, the subsequent review of the guidelines mandated 
      by the settlement was compromised by a lack of impartiality at various stages of 
      the IDSA review process. This article will examine the interplay between the
      recent calls for guidelines reform, the ethical canons of medicine, and due
      process considerations under antitrust laws as they apply to the formulation of
      the IDSA Lyme disease treatment guidelines. The article will also discuss
      pitfalls in the implementation of the IDSA antitrust settlement that should be
      avoided in the future.
FAU - Johnson, Lorraine
AU  - Johnson L
AD  - California Lyme Disease Association, Ukiah, CA, USA.
FAU - Stricker, Raphael B
AU  - Stricker RB
LA  - eng
PT  - Journal Article
DEP - 20100609
PL  - England
TA  - Philos Ethics Humanit Med
JT  - Philosophy, ethics, and humanities in medicine : PEHM
JID - 101258058
SB  - IM
MH  - Antitrust Laws
MH  - Codes of Ethics
MH  - Conflict of Interest/*legislation & jurisprudence
MH  - Connecticut
MH  - Dissent and Disputes
MH  - *Ethics, Medical
MH  - Evidence-Based Medicine/ethics/legislation & jurisprudence
MH  - Health Care Reform/ethics/legislation & jurisprudence
MH  - Humans
MH  - Lyme Disease/*drug therapy/therapy
MH  - Physician-Patient Relations/ethics
MH  - *Practice Guidelines as Topic/standards
MH  - Societies, Medical/*ethics/legislation & jurisprudence
MH  - United States
PMC - PMC2901226
EDAT- 2010/06/10 06:00
MHDA- 2011/06/15 06:00
CRDT- 2010/06/10 06:00
PHST- 2010/01/28 00:00 [received]
PHST- 2010/06/09 00:00 [accepted]
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2011/06/15 06:00 [medline]
AID - 1747-5341-5-9 [pii]
AID - 10.1186/1747-5341-5-9 [doi]
PST - epublish
SO  - Philos Ethics Humanit Med. 2010 Jun 9;5:9. doi: 10.1186/1747-5341-5-9.


PMID- 20529340
OWN - NLM
STAT- MEDLINE
DCOM- 20100715
LR  - 20211020
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 11
DP  - 2010 Jun 8
TI  - Is informed consent related to success in exercise and diet intervention as
      evaluated at 12 months? DR's EXTRA study.
PG  - 9
LID - 10.1186/1472-6939-11-9 [doi]
AB  - BACKGROUND: There is a permanent need to evaluate and develop the ethical quality
      of scientific research and to widen knowledge about the effects of ethical
      issues. Therefore we evaluated whether informed consent is related to
      implementation and success in a lifestyle intervention study with older research 
      participants. There is little empirical research into this topic. METHODS: The
      subjects (n = 597) are a subgroup of a random population sample of 1410 men and
      women aged 57-78 years who are participating in a 4-year randomized controlled
      intervention trial on the effects of physical exercise and diet on
      atherosclerosis, endothelial function and cognition. Data were collected in two
      steps: A questionnaire about informed consent was given to all willing
      participants (n = 1324) three months after the randomization. Data on
      implementation and success in the exercise and diet interventions were evaluated 
      at 12 months by intervention-group personnel. The main purpose of the analysis
      procedure performed in this study was to identify and examine potential
      correlates for the chosen dependent variables and to generate future hypotheses
      for testing and confirming the independent determinants for implementation and
      success. The nature of the analysis protocol is exploratory at this stage.
      RESULTS: About half of the participants (54%) had achieved good results in the
      intervention. Nearly half of the participants (47%) had added to or improved
      their own activity in some sector of exercise or diet. Significant associations
      were found between performance in the interventions and participants' knowledge
      of the purpose of the study (p < 0.001), and between success in interventions and
      working status (p = 0.02), and the participants' knowledge of the purpose of the 
      study (p = 0.04). CONCLUSION: The main finding of this study was that those
      participants who were most aware or had understood the purpose of the study at an
      early stage had also attained better results at their 12-month intervention
      evaluation. Therefore, implementation and success in intervention is related to
      whether subjects receive a sufficient amount and are able to comprehend the
      information provided i.e. the core principles of informed consent. TRIAL
      REGISTRATION: (ISRCTN 45977199).
FAU - Lansimies-Antikainen, Helena
AU  - Lansimies-Antikainen H
AD  - Department of Nursing Science, University of Eastern Finland, Yliopistonranta 1, 
      70211 Kuopio, Finland. helena.lansimies-antikainen@uef.fi
FAU - Pietila, Anna-Maija
AU  - Pietila AM
FAU - Laitinen, Tomi
AU  - Laitinen T
FAU - Kiviniemi, Vesa
AU  - Kiviniemi V
FAU - Rauramaa, Rainer
AU  - Rauramaa R
LA  - eng
SI  - ISRCTN/ISRCTN45977199
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20100608
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Aged
MH  - Atherosclerosis/therapy
MH  - Cognition
MH  - Comprehension
MH  - Endothelium, Vascular/physiopathology
MH  - Ethics, Research
MH  - *Exercise
MH  - *Feeding Behavior
MH  - Female
MH  - Finland
MH  - Goals
MH  - Humans
MH  - *Informed Consent/ethics
MH  - *Life Style
MH  - Male
MH  - Middle Aged
MH  - *Patient Education as Topic/ethics
MH  - Surveys and Questionnaires
MH  - Therapeutic Human Experimentation/*ethics
MH  - Time Factors
MH  - Treatment Outcome
PMC - PMC2891796
EDAT- 2010/06/10 06:00
MHDA- 2010/07/16 06:00
CRDT- 2010/06/10 06:00
PHST- 2009/06/07 00:00 [received]
PHST- 2010/06/08 00:00 [accepted]
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2010/07/16 06:00 [medline]
AID - 1472-6939-11-9 [pii]
AID - 10.1186/1472-6939-11-9 [doi]
PST - epublish
SO  - BMC Med Ethics. 2010 Jun 8;11:9. doi: 10.1186/1472-6939-11-9.


PMID- 20529339
OWN - NLM
STAT- MEDLINE
DCOM- 20120105
LR  - 20211020
IS  - 1471-2458 (Electronic)
IS  - 1471-2458 (Linking)
VI  - 10
DP  - 2010 Jun 8
TI  - Shared principles of ethics for infant and young child nutrition in the
      developing world.
PG  - 321
LID - 10.1186/1471-2458-10-321 [doi]
AB  - BACKGROUND: The defining event in the area of infant feeding is the aggressive
      marketing of infant formula in the developing world by transnational companies in
      the 1970s. This practice shattered the trust of the global health community in
      the private sector, culminated in a global boycott of Nestle products and has
      extended to distrust of all commercial efforts to improve infant and young child 
      nutrition. The lack of trust is a key barrier along the critical path to optimal 
      infant and young child nutrition in the developing world. DISCUSSION: To begin to
      bridge this gap in trust, we developed a set of shared principles based on the
      following ideals: Integrity; Solidarity; Justice; Equality; Partnership,
      cooperation, coordination, and communication; Responsible Activity;
      Sustainability; Transparency; Private enterprise and scale-up; and Fair trading
      and consumer choice. We hope these principles can serve as a platform on which
      various parties in the in the infant and young child nutrition arena, can begin a
      process of authentic trust-building that will ultimately result in coordinated
      efforts amongst parties. SUMMARY: A set of shared principles of ethics for infant
      and young child nutrition in the developing world could catalyze the scale-up of 
      low cost, high quality, complementary foods for infants and young children, and
      eventually contribute to the eradication of infant and child malnutrition in the 
      developing world.
FAU - Singh, Jerome Amir
AU  - Singh JA
AD  - McLaughlin-Rotman Centre for Global Health, University Health Network and
      University of Toronto, Toronto, Ontario, Canada. singhj9@ukzn.ac.za
FAU - Daar, Abdallah S
AU  - Daar AS
FAU - Singer, Peter A
AU  - Singer PA
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20100608
PL  - England
TA  - BMC Public Health
JT  - BMC public health
JID - 100968562
SB  - IM
MH  - Adult
MH  - Cooperative Behavior
MH  - *Developing Countries
MH  - Female
MH  - Humans
MH  - Infant Food
MH  - *Infant Nutritional Physiological Phenomena
MH  - Infant, Newborn
MH  - Male
MH  - *Nutrition Policy
MH  - *Social Responsibility
PMC - PMC2906463
EDAT- 2010/06/10 06:00
MHDA- 2012/01/06 06:00
CRDT- 2010/06/10 06:00
PHST- 2009/12/30 00:00 [received]
PHST- 2010/06/08 00:00 [accepted]
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2012/01/06 06:00 [medline]
AID - 1471-2458-10-321 [pii]
AID - 10.1186/1471-2458-10-321 [doi]
PST - epublish
SO  - BMC Public Health. 2010 Jun 8;10:321. doi: 10.1186/1471-2458-10-321.


PMID- 20529272
OWN - NLM
STAT- MEDLINE
DCOM- 20110613
LR  - 20211020
IS  - 1747-5341 (Electronic)
IS  - 1747-5341 (Linking)
VI  - 5
DP  - 2010 Jun 7
TI  - Ambient Assistive Technologies (AAT): socio-technology as a powerful tool for
      facing the inevitable sociodemographic challenges?
PG  - 8
LID - 10.1186/1747-5341-5-8 [doi]
AB  - Due to the socio-demographic change in most developed western countries, elderly 
      populations have been continuously increasing. Therefore, preventive and
      assistive systems that allow elderly people to independently live in their own
      homes as long as possible will become an economical if not ethical necessity.
      These respective technologies are being developed under the term "Ambient
      Assistive Technologies" (AAT). The EU-funded AAT-project Ambient Lighting
      Assistance for an Ageing Population (ALADIN) has established the long-term goal
      to create an adaptive system capable of improving the residential lighting
      conditions of single living elderly persons also aiming at supporting the
      preservation of their independence.Results of an earlier survey revealed that the
      elderly perceived their current lighting situation as satisfactory, whereas
      interviewers assessed in-house lighting as too dark and risk-laden. The overall
      results of ALADIN showed a significant increase in well-being from the baseline
      final testing with the new adaptive lighting system.Positive results for
      wellbeing and life quality suggest that the outcome effects may be attributed to 
      the introduction of technology as well as to social contacts arising from
      participating in the study. The technological guidance of the study supervisors, 
      in particular, may have produced a strong social reactivity effect that was first
      observed in the famous Hawthorne experiments in the 1930s. As older adults seem
      to benefit both from meaningful social contacts as well as assistive
      technologies, the question arises how assistive technology can be socially
      embedded to be able to maximize positive health effects. Therefore ethical
      guidelines for development and use of new assistive technologies for
      handicapped/older persons have to be developed and should be discussed with
      regard to their applicability in the context of AAT.
FAU - Schulke, Astrid M
AU  - Schulke AM
AD  - Generation Research Program, Human Science Center, Ludwig-Maximilians-University 
      Munich, Germany. schuelke@grp.hwz.uni-muenchen.de
FAU - Plischke, Herbert
AU  - Plischke H
FAU - Kohls, Niko B
AU  - Kohls NB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100607
PL  - England
TA  - Philos Ethics Humanit Med
JT  - Philosophy, ethics, and humanities in medicine : PEHM
JID - 101258058
SB  - IM
MH  - Aging
MH  - Demography
MH  - *Developing Countries
MH  - Environment Design
MH  - European Union
MH  - Health Promotion
MH  - Health Services for the Aged
MH  - Humans
MH  - *Independent Living
MH  - *Lighting
MH  - Medical Laboratory Science/trends
MH  - Quality of Life/psychology
MH  - *Residence Characteristics
MH  - Self-Help Devices/*trends
MH  - Socioeconomic Factors
MH  - *Vision, Ocular
PMC - PMC2898672
EDAT- 2010/06/10 06:00
MHDA- 2011/06/15 06:00
CRDT- 2010/06/10 06:00
PHST- 2010/03/26 00:00 [received]
PHST- 2010/06/07 00:00 [accepted]
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2011/06/15 06:00 [medline]
AID - 1747-5341-5-8 [pii]
AID - 10.1186/1747-5341-5-8 [doi]
PST - epublish
SO  - Philos Ethics Humanit Med. 2010 Jun 7;5:8. doi: 10.1186/1747-5341-5-8.


PMID- 20528698
OWN - NLM
STAT- MEDLINE
DCOM- 20110214
LR  - 20220409
IS  - 1943-3670 (Electronic)
IS  - 0022-3492 (Linking)
VI  - 81
IP  - 10
DP  - 2010 Oct
TI  - Bacterial adhesion on commercially pure titanium and anatase-coated titanium
      healing screws: an in vivo human study.
PG  - 1466-71
LID - 10.1902/jop.2010.100061 [doi]
AB  - BACKGROUND: Little is known about the mechanisms of bacterial interaction with
      implant materials in the oral cavity. Other surface characteristics, in addition 
      to surface roughness, seem to be extremely important in relation to plaque
      formation. Different adhesion affinities of bacteria were reported for different 
      materials. Anatase is a nanoparticle that can be applied to titanium surfaces as 
      a coating. The anatase coating gives special characteristics to the implant
      surface, including some genetic effects on osteoblasts. In this study, the
      antibacterial effect of anatase is investigated. The aim of this study is to
      characterize the percentages of surfaces covered by bacteria on commercially pure
      (cp) titanium and anatase-coated healing screws. METHODS: Ten patients
      participated in this study. The protocol of the study was approved by the ethics 
      committee of the University of Chieti-Pescara. A total of 20 healing screws (10
      test and 10 control screws) were used in the study. The control screws were made 
      of cp titanium, whereas the test screws were coated with anatase. Cleaning
      procedures and agents for chemical plaque control were not applied to the healing
      screws for the complete duration of the test period. After 7 days, all healing
      screws were removed, substituted, and processed under scanning electron
      microscopy for evaluation of the portions of the surfaces covered by bacteria.
      RESULTS: The supracrestal screw surfaces covered by bacteria on test specimens
      were not significantly lower than those of control screws (P = 0.174). The
      subcrestal screw surfaces and threads covered by bacteria on test specimens were 
      significantly lower than those of control screws, and P values were 0.001 and
      0.000, respectively. CONCLUSION: Results show that anatase could be a suitable
      material for coating implant abutments, with a low colonization potential.
FAU - Scarano, Antonio
AU  - Scarano A
AD  - Department of Stomatology and Oral Science, Dental School, University of
      Chieti-Pescara, Italy. ascarano@unich.it
FAU - Piattelli, Adriano
AU  - Piattelli A
FAU - Polimeni, Antonella
AU  - Polimeni A
FAU - Di Iorio, Donato
AU  - Di Iorio D
FAU - Carinci, Francesco
AU  - Carinci F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Periodontol
JT  - Journal of periodontology
JID - 8000345
RN  - 0 (Coated Materials, Biocompatible)
RN  - 0 (Dental Implants)
RN  - 15FIX9V2JP (titanium dioxide)
RN  - D1JT611TNE (Titanium)
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - *Bacterial Adhesion
MH  - *Coated Materials, Biocompatible
MH  - Colony Count, Microbial
MH  - Dental Implants/*microbiology
MH  - Dental Plaque/microbiology
MH  - Female
MH  - Humans
MH  - Male
MH  - *Titanium
MH  - Young Adult
EDAT- 2010/06/10 06:00
MHDA- 2011/02/15 06:00
CRDT- 2010/06/10 06:00
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2011/02/15 06:00 [medline]
AID - 10.1902/jop.2010.100061 [doi]
PST - ppublish
SO  - J Periodontol. 2010 Oct;81(10):1466-71. doi: 10.1902/jop.2010.100061.


PMID- 20528681
OWN - NLM
STAT- MEDLINE
DCOM- 20120622
LR  - 20151119
IS  - 1473-0782 (Electronic)
IS  - 1362-5187 (Linking)
VI  - 15
IP  - 4
DP  - 2010 Aug
TI  - Social and ethical determinants of human sexuality: 2. Gender-based violence.
PG  - 220-31
LID - 10.3109/13625187.2010.490888 [doi]
AB  - OBJECTIVES: To describe the many forms of gender-based violence and their
      consequences for society and women's health, focusing on various aspects of the
      problem, including harassment, stalking, incapacitated rape and war-related
      violence. METHODS: For each main area a search was made using PubMed, Medline,
      ScienceDirect, Scopus, classic books, Google and religious websites. The most
      relevant publications were then utilised for preparing the manuscript. RESULTS:
      Gender-based violence persists worldwide in spite of efforts by many governments 
      and international organisations to quench it. Men continue to exercise dominance 
      over women, often their own or prospective partners or dates. Abuses are
      physical, psychological or verbal; they all aim at subduing women. Those that
      occur during pregnancy are associated with an increased risk of adverse outcomes.
      Acts of violence can take the form of aggression, coercion, harassment or
      trafficking; are often committed against minors; may be prompted by an
      ill-conceived need to defend the family honour and be widespread during armed
      conflicts. CONCLUSIONS: Men's violent sexual behaviour has often been interpreted
      as a consequence of blind sexual drive. Today, however, aggressive behaviour is
      considered to be sensitive to and influenced by environmental cues. Eradication
      is possible and efforts to eliminate gender-based violence should be intensified.
FAU - Benagiano, Giuseppe
AU  - Benagiano G
AD  - Department of Obstetrics and Gynaecology, "Sapienza", University of Rome, Roma,
      Italy. Giuseppe.Benagiano@uniroma1.it
FAU - Carrara, Sabina
AU  - Carrara S
FAU - Filippi, Valentina
AU  - Filippi V
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur J Contracept Reprod Health Care
JT  - The European journal of contraception & reproductive health care : the official
      journal of the European Society of Contraception
JID - 9712127
SB  - IM
MH  - Adult
MH  - Aggression/psychology
MH  - Domestic Violence/*ethics/*psychology
MH  - Female
MH  - Humans
MH  - *Interpersonal Relations
MH  - Male
MH  - Pregnancy
MH  - Rape/psychology
MH  - *Sex Characteristics
MH  - Sexual Harassment/psychology
MH  - Sexuality/*ethics
MH  - Warfare
EDAT- 2010/06/10 06:00
MHDA- 2012/06/23 06:00
CRDT- 2010/06/10 06:00
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2012/06/23 06:00 [medline]
AID - 10.3109/13625187.2010.490888 [doi]
PST - ppublish
SO  - Eur J Contracept Reprod Health Care. 2010 Aug;15(4):220-31. doi:
      10.3109/13625187.2010.490888.


PMID- 20528661
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20100610
IS  - 1369-1627 (Electronic)
IS  - 0954-0261 (Linking)
VI  - 22
IP  - 3
DP  - 2010
TI  - Ethics and professionalism preparation for psychiatrists-in-training: A
      curricular proposal.
PG  - 301-5
LID - 10.3109/09540261.2010.482095 [doi]
AB  - Potential ethical issues and challenges to professionalism arise commonly in the 
      care of patients with psychiatric illnesses. As such, education and training in
      medical ethics especially as applied to psychiatry and professionalism should be 
      offered to trainees during the formative years of residency and fellowship. This 
      article proposes a curriculum for senior residents and fellows that uses a
      case-centred seminar to discuss ethical dilemmas, approaches to analysing ethical
      issues, and to develop a course of action for resolution. Representative ethical 
      issues and the clinical arenas in which these are most likely to arise are
      suggested.
FAU - Tsao, Carol I Ping
AU  - Tsao CI
AD  - Medical College of Wisconsin, Clement J Zablocki VAMC, Milwaukee, Wisconsin
      53295, USA. ctsao@mcw.edu
FAU - Guedet, Patty J
AU  - Guedet PJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int Rev Psychiatry
JT  - International review of psychiatry (Abingdon, England)
JID - 8918131
SB  - IM
MH  - *Curriculum
MH  - *Ethics, Professional
MH  - Humans
MH  - *Internship and Residency
MH  - *Professional Competence
MH  - Psychiatry/*education
EDAT- 2010/06/10 06:00
MHDA- 2010/09/15 06:00
CRDT- 2010/06/10 06:00
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2010/09/15 06:00 [medline]
AID - 10.3109/09540261.2010.482095 [doi]
PST - ppublish
SO  - Int Rev Psychiatry. 2010;22(3):301-5. doi: 10.3109/09540261.2010.482095.


PMID- 20528660
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20100610
IS  - 1369-1627 (Electronic)
IS  - 0954-0261 (Linking)
VI  - 22
IP  - 3
DP  - 2010
TI  - Guarding the guardians: Bioethics curricula for psychiatrists-in-training in
      developing countries.
PG  - 294-300
LID - 10.3109/09540261.2010.482096 [doi]
AB  - A good physician must be both clinically and ethically competent. High ethical
      standards are especially important in psychiatry in which several unique
      challenges present due to a vulnerable patient population, intimate
      physician-patient relationships, diagnoses made on signs and symptoms rather than
      irrefutable laboratory investigations, and therapeutic options directed at
      altering thinking and behaviour. It is critical that psychiatric training equip
      practitioners with the ability to identify ethical dilemmas in clinical practice 
      and research and respond appropriately. Despite a call to action and the
      development of guidelines for ethical practice by several regulatory bodies,
      formal ethics teaching in psychiatry training programmes is still in embryonic
      stages in the developed world and virtually non-existent in the developing world.
      Here we highlight the current status of bioethics teaching in psychiatry
      residency programmes in Pakistan, an example of a developing country where such
      training is vital, as unethical practices abound in resource-poor settings where 
      clinical and research practices are non-transparent and there are no effective
      regulatory, legal and accountability bodies. It is critical and urgent that
      needs-responsive bioethics curricula are developed, institutionalized and
      implemented in medical schools and post-graduate training programs across the
      developing world. [Box: see text] [Box: see text].
FAU - Ghias, Kulsoom
AU  - Ghias K
AD  - Department of Biological and Biomedical Sciences, Aga Khan University, Karachi,
      Pakistan. kulsoom.ghias@aku.edu <kulsoom.ghias@aku.edu>
FAU - Ahmer, Syed
AU  - Ahmer S
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Int Rev Psychiatry
JT  - International review of psychiatry (Abingdon, England)
JID - 8918131
SB  - IM
MH  - *Bioethics
MH  - *Curriculum
MH  - *Developing Countries
MH  - Education
MH  - Humans
MH  - Internship and Residency/*standards
MH  - Needs Assessment
MH  - Psychiatry/*education/*standards
RF  - 43
EDAT- 2010/06/10 06:00
MHDA- 2010/09/15 06:00
CRDT- 2010/06/10 06:00
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2010/09/15 06:00 [medline]
AID - 10.3109/09540261.2010.482096 [doi]
PST - ppublish
SO  - Int Rev Psychiatry. 2010;22(3):294-300. doi: 10.3109/09540261.2010.482096.


PMID- 20528659
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20100610
IS  - 1369-1627 (Electronic)
IS  - 0954-0261 (Linking)
VI  - 22
IP  - 3
DP  - 2010
TI  - 'The one truly serious philosophical problem': Ethical aspects of suicide.
PG  - 288-93
LID - 10.3109/09540261.2010.484017 [doi]
AB  - Suicide is a major global public health problem with an estimated one million
      deaths every year. It is one of the most personal yet one of the most complex
      acts anyone can perform, as it goes to the very core of the concept of human
      existence and the meaning of life. The philosophical debate on suicide has
      spanned centuries with no clear answers. Juxtaposed within the various
      perspectives that suicide can be studied from is the ethical perspective that
      brings into sharp focus the conflict between personal autonomy and societal
      responsibility towards suicidal individuals. Mental health professionals find
      themselves in the midst of this conflict as they are assumed to have the
      responsibility to prevent suicide in their patients, while patients'
      responsibility towards themselves is frequently overlooked. Mental health
      professionals need to be aware of the ethical concerns that arise in the care of 
      suicidal patients.
FAU - Khan, Murad M
AU  - Khan MM
AD  - Department of Psychiatry, Aga Khan University, Karachi, Pakistan.
      murad.khan@aku.edu <murad.khan@aku.edu>
FAU - Mian, Ayesha I
AU  - Mian AI
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Int Rev Psychiatry
JT  - International review of psychiatry (Abingdon, England)
JID - 8918131
SB  - IM
MH  - Culture
MH  - *Ethics
MH  - Female
MH  - Humans
MH  - Male
MH  - Mental Health Services/*ethics
MH  - Personal Autonomy
MH  - Sex Factors
MH  - Social Responsibility
MH  - Social Support
MH  - *Suicide
RF  - 44
EDAT- 2010/06/10 06:00
MHDA- 2010/09/15 06:00
CRDT- 2010/06/10 06:00
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2010/09/15 06:00 [medline]
AID - 10.3109/09540261.2010.484017 [doi]
PST - ppublish
SO  - Int Rev Psychiatry. 2010;22(3):288-93. doi: 10.3109/09540261.2010.484017.


PMID- 20528658
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20100610
IS  - 1369-1627 (Electronic)
IS  - 0954-0261 (Linking)
VI  - 22
IP  - 3
DP  - 2010
TI  - Ethical perspectives on relations between industry and neuropsychiatric medicine.
PG  - 281-7
LID - 10.3109/09540261.2010.484014 [doi]
AB  - Conflicts of interest may influence medical research. In particular, the study on
      psychotropic treatment of ageing subjects suffering from neurological disorders
      and comorbid neuropsychiatric phenomena may be hypothetically considered
      economically non-advantageous, or even of negative impact on drug reputation,
      because of the high probability of non-response or side effects. Thus, studies on
      this issue may be disregarded from industry. We aimed to verify whether the
      global commitment of medical research reflects the actual relevance of depression
      in the world ageing population, associated or not with neurological conditions.
      Here, we: 1) have reviewed the literature on this issue, 2) have examined world
      published data concerning population by age, burden of disease and frequency of
      depressive disorders and antidepressant therapies, and 3) have reviewed the
      frequency of published papers on depression and its treatment associated with
      three neurological conditions. The overall rate of papers about depressive
      disorders in ageing people reflects adequately the world population and the
      prevalence of depression in the elderly. However, the rate of papers concerning
      medical experimentation for antidepressant treatment in Alzheimer's disease,
      Parkinson's disease and stroke is quite inadequate with respect to the rate of
      depressive disorders associated to these conditions. Thus, innovative medical
      experimentation must be encouraged, also in areas apparently of dubious
      economical advantage but of undoubted clinical relevance and the adoption of
      strategies to limit the detrimental effect of conflicts of interest in research
      must be enhanced.
FAU - Orfei, Maria Donata
AU  - Orfei MD
AD  - IRCCS Santa Lucia Foundation, Rome, Italy.
FAU - Caltagirone, Carlo
AU  - Caltagirone C
FAU - Spalletta, Gianfranco
AU  - Spalletta G
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Int Rev Psychiatry
JT  - International review of psychiatry (Abingdon, England)
JID - 8918131
RN  - 0 (Antidepressive Agents)
SB  - IM
MH  - Alzheimer Disease/psychology
MH  - Antidepressive Agents/*therapeutic use
MH  - Brain/*physiopathology
MH  - Conflict of Interest
MH  - Cost of Illness
MH  - Depressive Disorder/*drug therapy/etiology
MH  - Drug Industry/*ethics
MH  - Humans
MH  - Parkinson Disease/psychology
MH  - Psychiatry/*ethics/*methods
MH  - Stroke/psychology
MH  - Therapies, Investigational
RF  - 68
EDAT- 2010/06/10 06:00
MHDA- 2010/09/15 06:00
CRDT- 2010/06/10 06:00
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2010/09/15 06:00 [medline]
AID - 10.3109/09540261.2010.484014 [doi]
PST - ppublish
SO  - Int Rev Psychiatry. 2010;22(3):281-7. doi: 10.3109/09540261.2010.484014.


PMID- 20528657
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20131121
IS  - 1369-1627 (Electronic)
IS  - 0954-0261 (Linking)
VI  - 22
IP  - 3
DP  - 2010
TI  - Ethical perspectives in caring for people living with addictions: The European
      experience.
PG  - 274-80
LID - 10.3109/09540261.2010.482097 [doi]
AB  - European policy and practice in caring for people living with addictions is based
      on defined values (human rights, medical ethics) and on research evidence for the
      effects and impact of interventions. The focus of the paper is on risk management
      approaches to reduce the negative consequences of continued illicit drug use,
      being the ethically most debatable issue. The legal and policy positions are set 
      by the European Council and Commission, and their translation into practice is
      documented centrally in the European Monitoring Centre on Drugs and Drug
      Addiction, showing the general trends as well as national differences. The
      European experience with the risk management approaches is presented in terms of 
      research evidence on their effects and side-effects; this evidence is justifying 
      the present practice. The perspectives for the future are set to follow the same 
      lines, in a continued effort to find a balance of interests, in cooperation of
      authorities and civil society, and guided by ongoing research.
FAU - Uchtenhagen, Ambros A
AU  - Uchtenhagen AA
AD  - Research Institute for Public Health and Addiction, WHO Collaborating Centre for 
      Substance Abuse, Zurich University, Switzerland. uchtenhagen@isgf.uzh.ch
      <uchtenhagen@isgf.uzh.ch>
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Int Rev Psychiatry
JT  - International review of psychiatry (Abingdon, England)
JID - 8918131
RN  - 0 (Narcotic Antagonists)
RN  - UC6VBE7V1Z (Methadone)
SB  - IM
MH  - Europe/epidemiology
MH  - Health Promotion
MH  - Humans
MH  - Mental Health Services/*ethics/organization & administration/statistics &
      numerical data
MH  - Methadone/therapeutic use
MH  - Narcotic Antagonists/therapeutic use
MH  - Needle-Exchange Programs/organization & administration
MH  - Substance Abuse Treatment Centers/organization & administration/statistics &
      numerical data
MH  - Substance-Related Disorders/epidemiology/*rehabilitation
RF  - 39
EDAT- 2010/06/10 06:00
MHDA- 2010/09/15 06:00
CRDT- 2010/06/10 06:00
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2010/09/15 06:00 [medline]
AID - 10.3109/09540261.2010.482097 [doi]
PST - ppublish
SO  - Int Rev Psychiatry. 2010;22(3):274-80. doi: 10.3109/09540261.2010.482097.


PMID- 20528656
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20191210
IS  - 1369-1627 (Electronic)
IS  - 0954-0261 (Linking)
VI  - 22
IP  - 3
DP  - 2010
TI  - Ethical issues in geriatric psychiatry.
PG  - 267-73
LID - 10.3109/09540261.2010.484016 [doi]
AB  - The high rates of medical illness in older people, the high prevalence of
      cognitive disorder in the elderly, and the high prevalence of frailty in late
      life raise issues that occur infrequently in the care of younger adults. This
      article discusses the ethical issues that commonly arise in the setting of these 
      medical and psychiatric morbidities, and emphasizes the need for clinicians and
      researchers to be knowledgeable about the belief systems and values of individual
      patients, of their carers when relevant, of themselves, and of research
      participants.
FAU - Rabins, Peter V
AU  - Rabins PV
AD  - Department of Psychiatry and Behavioral Sciences, Berman Institute of Bioethics, 
      Johns Hopkins University, Baltimore, Maryland, USA. pvrabins@jhmi.edu
      <pvrabins@jhmi.edu>
FAU - Black, Betty S
AU  - Black BS
LA  - eng
GR  - AG021130/AG/NIA NIH HHS/United States
GR  - AG021334/AG/NIA NIH HHS/United States
GR  - AG031348/AG/NIA NIH HHS/United States
GR  - AG30036/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Int Rev Psychiatry
JT  - International review of psychiatry (Abingdon, England)
JID - 8918131
SB  - IM
MH  - Accidental Falls/statistics & numerical data
MH  - Adult
MH  - Aged
MH  - Automobile Driving/statistics & numerical data
MH  - Caregivers
MH  - Cognition Disorders/epidemiology
MH  - Countertransference
MH  - Decision Making
MH  - Elder Abuse/statistics & numerical data
MH  - Geriatric Psychiatry/*ethics
MH  - Humans
MH  - Mental Disorders/epidemiology/*therapy
MH  - Mental Health Services/*ethics
MH  - Middle Aged
MH  - Professional-Patient Relations
MH  - Proxy
RF  - 26
EDAT- 2010/06/10 06:00
MHDA- 2010/09/15 06:00
CRDT- 2010/06/10 06:00
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2010/09/15 06:00 [medline]
AID - 10.3109/09540261.2010.484016 [doi]
PST - ppublish
SO  - Int Rev Psychiatry. 2010;22(3):267-73. doi: 10.3109/09540261.2010.484016.


PMID- 20528655
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20100610
IS  - 1369-1627 (Electronic)
IS  - 0954-0261 (Linking)
VI  - 22
IP  - 3
DP  - 2010
TI  - Ethics in child and adolescent psychiatric care: An international perspective.
PG  - 258-66
LID - 10.3109/09540261.2010.485979 [doi]
AB  - In the treatment of children with psychiatric disorders as a vulnerable
      population, ethical issues arise that seldom come into play with adults. The UN
      Conventions on the Rights of the Child and the Rights of Persons with
      Disabilities set out rights to be respected in child and adolescent psychiatric
      treatment. Rights of participation and inclusion (minimizing of barriers to the
      involvement of disabled people) can create complex problems in cases of restraint
      or deprivation of liberty. This paper analyses the consequences of these
      conventions and other ethics guidelines on child and adolescent psychiatric
      treatment and research. Beneficence, justice and autonomy are core principles
      that are mirrored in the problems of inclusion and protection, confidentiality,
      and the safety of psychopharmacological interventions. Factors of inclusion are
      involved in the areas of availability of care, participation in best
      evidence-based treatment, and research. The right of the child to protection, the
      right of inclusion, and parents' rights and duties to safeguard their child's
      wellbeing form a triangle. National laws to regulate the treatment of
      psychiatrically ill children should be created and implemented and these should
      be non-discriminatory but at the same time safeguard the developing human being.
FAU - Koelch, Michael
AU  - Koelch M
AD  - Department of Child and Adolescent Psychiatry and Psychotherapy, University
      Hospital of Ulm, Germany. michael.koelch@uniklinik-ulm.de
      <michael.koelch@uniklinik-ulm.de>
FAU - Fegert, Joerg M
AU  - Fegert JM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Int Rev Psychiatry
JT  - International review of psychiatry (Abingdon, England)
JID - 8918131
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - *Ethics, Professional
MH  - Health Services Accessibility/organization & administration
MH  - Humans
MH  - *International Cooperation
MH  - Mental Disorders/*therapy
MH  - Mental Health Services/ethics/*organization & administration
MH  - Psychiatry/*ethics
MH  - United Nations
MH  - Vulnerable Populations
RF  - 90
EDAT- 2010/06/10 06:00
MHDA- 2010/09/15 06:00
CRDT- 2010/06/10 06:00
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2010/09/15 06:00 [medline]
AID - 10.3109/09540261.2010.485979 [doi]
PST - ppublish
SO  - Int Rev Psychiatry. 2010;22(3):258-66. doi: 10.3109/09540261.2010.485979.


PMID- 20528654
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20151119
IS  - 1369-1627 (Electronic)
IS  - 0954-0261 (Linking)
VI  - 22
IP  - 3
DP  - 2010
TI  - Ethical aspects in providing care to marginalized populations.
PG  - 252-7
LID - 10.3109/09540261.2010.484015 [doi]
FAU - Kastrup, Marianne
AU  - Kastrup M
AD  - Centre for Transcultural Psychiatry, Copenhagen, Denmark.
      marianne.kastrup@regionh.dk <marianne.kastrup@regionh.dk>
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Int Rev Psychiatry
JT  - International review of psychiatry (Abingdon, England)
JID - 8918131
SB  - IM
MH  - Communication
MH  - Cultural Diversity
MH  - Culture
MH  - Decision Making, Organizational
MH  - Denmark
MH  - Emigrants and Immigrants
MH  - *Ethics, Professional
MH  - Humans
MH  - Mental Health Services/*ethics/*supply & distribution
MH  - Practice Patterns, Physicians'/organization & administration
MH  - Professional-Patient Relations
MH  - Social Values
MH  - Socioeconomic Factors
MH  - Translating
MH  - *Vulnerable Populations
MH  - World Health Organization
RF  - 38
EDAT- 2010/06/10 06:00
MHDA- 2010/09/15 06:00
CRDT- 2010/06/10 06:00
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2010/09/15 06:00 [medline]
AID - 10.3109/09540261.2010.484015 [doi]
PST - ppublish
SO  - Int Rev Psychiatry. 2010;22(3):252-7. doi: 10.3109/09540261.2010.484015.


PMID- 20528653
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20181201
IS  - 1369-1627 (Electronic)
IS  - 0954-0261 (Linking)
VI  - 22
IP  - 3
DP  - 2010
TI  - Ethical and professional challenges in mental health care in low- and
      middle-income countries.
PG  - 245-51
LID - 10.3109/09540261.2010.482557 [doi]
AB  - Mental health practitioners in low- and middle-income countries (LAMICs) face
      particular ethical and professional challenges in their day-to-day clinical
      practice. A systematic review of the published literature from all LAMICs
      identified 42 relevant articles. The majority of papers dealt with violations of 
      individual autonomy, particularly in the context of involuntary admission, use of
      electro-convulsive therapy and the lack of information given to patients about
      prescribed psychotropic medications. However, the appropriateness of this focus
      on individual autonomy was challenged in settings where values emphasizing the
      interconnectedness of communities prevail and the family shoulder the burden for 
      most mental health care. When access to the least restrictive, culturally
      relevant, evidence-based care is limited to the privileged few, caregivers may be
      forced to over-ride the individual autonomy of the patient in order to ensure
      receipt of effective treatment or protection of others. Enactment of modern
      mental health legislation in all LAMICs remains an essential goal to protect the 
      rights of the mentally ill. In parallel with this, supporting calls for the
      scaling up of mental health care will do more to ensure the right to mental
      health care and ensure actual implementation of international ethical frameworks.
FAU - Hanlon, Charlotte
AU  - Hanlon C
AD  - Department of Psychiatry, Addis Ababa University, Ethiopia.
      charlotte.hanlon@kcl.ac.uk <charlotte.hanlon@kcl.ac.uk>
FAU - Tesfaye, Markos
AU  - Tesfaye M
FAU - Wondimagegn, Dawit
AU  - Wondimagegn D
FAU - Shibre, Teshome
AU  - Shibre T
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
PL  - England
TA  - Int Rev Psychiatry
JT  - International review of psychiatry (Abingdon, England)
JID - 8918131
RN  - 0 (Psychotropic Drugs)
SB  - IM
MH  - *Codes of Ethics
MH  - Developing Countries/statistics & numerical data
MH  - Electroconvulsive Therapy/*methods
MH  - *Health Personnel
MH  - Humans
MH  - International Cooperation
MH  - Mental Disorders/drug therapy/*epidemiology/*therapy
MH  - Mental Health Services/*ethics/legislation & jurisprudence
MH  - Psychotropic Drugs/therapeutic use
MH  - Socioeconomic Factors
MH  - Workforce
MH  - World Health Organization
RF  - 100
EDAT- 2010/06/10 06:00
MHDA- 2010/09/15 06:00
CRDT- 2010/06/10 06:00
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2010/09/15 06:00 [medline]
AID - 10.3109/09540261.2010.482557 [doi]
PST - ppublish
SO  - Int Rev Psychiatry. 2010;22(3):245-51. doi: 10.3109/09540261.2010.482557.


PMID- 20528652
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20220408
IS  - 1369-1627 (Electronic)
IS  - 0954-0261 (Linking)
VI  - 22
IP  - 3
DP  - 2010
TI  - Mental disorders, health inequalities and ethics: A global perspective.
PG  - 235-44
LID - 10.3109/09540261.2010.485273 [doi]
AB  - The global burden of neuropsychiatry diseases and related mental health
      conditions is enormous, underappreciated and under resourced, particularly in the
      developing nations. The absence of adequate and quality mental health
      infrastructure and workforce is increasingly recognized. The ethical implications
      of inequalities in mental health for people and nations are profound and must be 
      addressed in efforts to fulfil key bioethics principles of medicine and public
      health: respect for individuals, justice, beneficence, and non-malfeasance.
      Stigma and discrimination against people living with mental disorders affects
      their education, employment, access to care and hampers their capacity to
      contribute to society. Mental health well-being is closely associated to several 
      Millennium Development Goals and economic development sectors including
      education, labour force participation, and productivity. Limited access to mental
      health care increases patient and family suffering. Unmet mental health needs
      have a negative effect on poverty reduction initiatives and economic development.
      Untreated mental conditions contribute to economic loss because they increase
      school and work absenteeism and dropout rates, healthcare expenditure, and
      unemployment. Addressing unmet mental health needs will require development of
      better mental health infrastructure and workforce and overall integration of
      mental and physical health services with primary care, especially in the
      developing nations.
FAU - Ngui, Emmanuel M
AU  - Ngui EM
AD  - Center for the Advancement of Urban Children, Department of Pediatrics, Medical
      College of Wisconsin, Milwaukee, 53226-0509, USA. engui@mcw.edu
FAU - Khasakhala, Lincoln
AU  - Khasakhala L
FAU - Ndetei, David
AU  - Ndetei D
FAU - Roberts, Laura Weiss
AU  - Roberts LW
LA  - eng
GR  - R01 MH074080/MH/NIMH NIH HHS/United States
GR  - R01 MH074080-03S1/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - England
TA  - Int Rev Psychiatry
JT  - International review of psychiatry (Abingdon, England)
JID - 8918131
SB  - IM
MH  - Brain/*physiopathology
MH  - Health Expenditures
MH  - Health Services Needs and Demand
MH  - Healthcare Disparities/economics/*ethics
MH  - Humans
MH  - Mental Disorders/economics/*physiopathology/*therapy
MH  - Mental Health Services/economics/*ethics/*supply & distribution
MH  - Prejudice
MH  - Psychiatry/economics/*ethics
MH  - Socioeconomic Factors
MH  - Stereotyping
MH  - Unemployment/statistics & numerical data
MH  - United States/epidemiology
RF  - 104
PMC - PMC2935265
MID - NIHMS226164
EDAT- 2010/06/10 06:00
MHDA- 2010/09/15 06:00
CRDT- 2010/06/10 06:00
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2010/09/15 06:00 [medline]
AID - 10.3109/09540261.2010.485273 [doi]
PST - ppublish
SO  - Int Rev Psychiatry. 2010;22(3):235-44. doi: 10.3109/09540261.2010.485273.


PMID- 20528651
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20100610
IS  - 1369-1627 (Electronic)
IS  - 0954-0261 (Linking)
VI  - 22
IP  - 3
DP  - 2010
TI  - Global challenges and ethics in protecting and promoting the interests of
      psychiatrically ill patients.
PG  - 229-34
LID - 10.3109/09540261.2010.486828 [doi]
FAU - Coverdale, John
AU  - Coverdale J
FAU - Roberts, Laura Weiss
AU  - Roberts LW
LA  - eng
PT  - Editorial
PL  - England
TA  - Int Rev Psychiatry
JT  - International review of psychiatry (Abingdon, England)
JID - 8918131
RN  - 0 (Psychotropic Drugs)
SB  - IM
MH  - Adaptation, Psychological
MH  - Culture
MH  - Empathy
MH  - *Health Promotion
MH  - Human Rights
MH  - Humans
MH  - Mental Disorders/drug therapy/*psychology/*therapy
MH  - Mental Health Services/*ethics/organization & administration
MH  - Morals
MH  - Patient Education as Topic
MH  - Psychiatry/*ethics
MH  - Psychotropic Drugs/therapeutic use
EDAT- 2010/06/10 06:00
MHDA- 2010/09/15 06:00
CRDT- 2010/06/10 06:00
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2010/09/15 06:00 [medline]
AID - 10.3109/09540261.2010.486828 [doi]
PST - ppublish
SO  - Int Rev Psychiatry. 2010;22(3):229-34. doi: 10.3109/09540261.2010.486828.


PMID- 20527648
OWN - NLM
STAT- MEDLINE
DCOM- 20100701
LR  - 20100609
IS  - 0030-9982 (Print)
IS  - 0030-9982 (Linking)
VI  - 60
IP  - 6
DP  - 2010 Jun
TI  - Seropositivity of hepatitis C in prison inmates of Pakistan--a cross sectional
      study in prisons of Sindh.
PG  - 476-9
AB  - OBJECTIVE: To assess the proportion of seropositivity of Hepatitis C amongst the 
      prison inmates in the jails of Sindh. METHODS: A cross sectional HCV
      seroprevalence survey was done at 14 out of 19 prisons in the Sindh province from
      November 2008 to January 2009. A team of Pathologist, phlebotomist and laboratory
      technician took the blood sample of the inmates inside the correctional facility;
      the blood was centrifuged at the spot and brought back to the pathology
      laboratory on same day in cold chain i.e. a temperature-controlled supply chain. 
      Serum was analyzed on 3rd generation ELISA for HCV antibodies. Standard ethical
      considerations were properly followed. RESULTS: Atotal of 9508 prison inmates
      were approached. Refusal rate was 20%. Remaining, 7539 prisoners were screened at
      14 out of 19 jails in Sindh. HCV antibody positive were 965 making the proportion
      of seropositivity 12.8% (95% C.I. 8.92% - 12.92%). Higher seropositivity in the
      jails of northern Sindh jails was identified. CONCLUSIONS: Hepatitis C prevalence
      in the prison population of Sindh is higher than the national prevalence of 4.9% 
      amongst general population. However it is lower than that reported from
      correctional facilities of developed countries. Hepatitis prevention and control 
      activities in the correctional facilities of Pakistan need to be
      institutionalized (JPMA 60:476; 2010).
FAU - Gorar, Zulfikar Ali
AU  - Gorar ZA
AD  - National Program for Prevention and Control of Hepatitis in Pakistan, Ministry of
      Health Government of Pakistan, Health Services Sindh, Old Wahdat Colony,
      Hyderabad.
FAU - Zulfikar, Imrana
AU  - Zulfikar I
LA  - eng
PT  - Journal Article
PL  - Pakistan
TA  - J Pak Med Assoc
JT  - JPMA. The Journal of the Pakistan Medical Association
JID - 7501162
RN  - 0 (Hepatitis C Antibodies)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Child
MH  - Cross-Sectional Studies
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Hepacivirus/isolation & purification
MH  - Hepatitis C/*epidemiology/prevention & control
MH  - Hepatitis C Antibodies/*blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pakistan/epidemiology
MH  - Prisoners/*statistics & numerical data
MH  - Prisons
MH  - Seroepidemiologic Studies
MH  - Young Adult
EDAT- 2010/06/10 06:00
MHDA- 2010/07/02 06:00
CRDT- 2010/06/10 06:00
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2010/07/02 06:00 [medline]
AID - 2107 [pii]
PST - ppublish
SO  - J Pak Med Assoc. 2010 Jun;60(6):476-9.


PMID- 20527583
OWN - NLM
STAT- MEDLINE
DCOM- 20100722
LR  - 20100609
IS  - 1029-4864 (Print)
IS  - 1029-4864 (Linking)
VI  - 65
IP  - 2
DP  - 2010 Mar
TI  - Ethics in dental practice: an overview.
PG  - 84-5
FAU - Moodley, K
AU  - Moodley K
AD  - Bioethics Unit-Tygerberg Division, University of Stellenbosch. km@sun.ac.za
FAU - Naidoo, S
AU  - Naidoo S
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - SADJ
JT  - SADJ : journal of the South African Dental Association = tydskrif van die
      Suid-Afrikaanse Tandheelkundige Vereniging
JID - 9812497
MH  - Bioethics
MH  - Dental Care/*ethics
MH  - Dentist-Patient Relations/ethics
MH  - Dentists/*ethics
MH  - Ethics, Dental
MH  - Holistic Health
MH  - Humans
MH  - Risk Management/ethics
MH  - Truth Disclosure/ethics
EDAT- 2010/06/10 06:00
MHDA- 2010/07/23 06:00
CRDT- 2010/06/10 06:00
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2010/07/23 06:00 [medline]
PST - ppublish
SO  - SADJ. 2010 Mar;65(2):84-5.


PMID- 20527574
OWN - NLM
STAT- MEDLINE
DCOM- 20100722
LR  - 20100609
IS  - 1029-4864 (Print)
IS  - 1029-4864 (Linking)
VI  - 65
IP  - 2
DP  - 2010 Mar
TI  - Ethics and dental care in the 21st century.
PG  - 50
LA  - eng
PT  - Editorial
PL  - South Africa
TA  - SADJ
JT  - SADJ : journal of the South African Dental Association = tydskrif van die
      Suid-Afrikaanse Tandheelkundige Vereniging
JID - 9812497
MH  - Dental Care/economics/*ethics
MH  - Dentist-Patient Relations/ethics
MH  - Dentists/*ethics
MH  - Empathy/ethics
MH  - Endodontics/economics/ethics
MH  - *Ethics, Dental
MH  - Fees, Dental/ethics
MH  - Humans
EDAT- 2010/06/10 06:00
MHDA- 2010/07/23 06:00
CRDT- 2010/06/10 06:00
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2010/07/23 06:00 [medline]
PST - ppublish
SO  - SADJ. 2010 Mar;65(2):50.


PMID- 20527564
OWN - NLM
STAT- MEDLINE
DCOM- 20100628
LR  - 20170214
IS  - 0094-2405 (Print)
IS  - 0094-2405 (Linking)
VI  - 37
IP  - 5
DP  - 2010 May
TI  - Off-label use of medical products in radiation therapy: summary of the report of 
      AAPM Task Group No. 121.
PG  - 2300-11
AB  - Medical products (devices, drugs, or biologics) contain information in their
      labeling regarding the manner in which the manufacturer has determined that the
      products can be used in a safe and effective manner. The Food and Drug
      Administration (FDA) approves medical products for use for these specific
      indications which are part of the medical product's labeling. When medical
      products are used in a manner not specified in the labeling, it is commonly
      referred to as off-label use. The practice of medicine allows for this off-label 
      use to treat individual patients, but the ethical and legal implications for such
      unapproved use can be confusing. Although the responsibility and, ultimately, the
      liability for off-label use often rests with the prescribing physician, medical
      physicists and others are also responsible for the safe and proper use of the
      medical products. When these products are used for purposes other than which they
      were approved, it is important for medical physicists to understand their
      responsibilities. In the United States, medical products can only be marketed if 
      officially cleared, approved, or licensed by the FDA; they can be used if they
      are not subject to or specifically exempt from FDA regulations, or if they are
      being used in research with the appropriate regulatory safeguards. Medical
      devices are either cleared or approved by FDA's Center for Devices and
      Radiological Health. Drugs are approved by FDA's Center for Drug Evaluation and
      Research, and biological products such as vaccines or blood are licensed under a 
      biologics license agreement by FDA's Center for Biologics Evaluation and
      Research. For the purpose of this report, the process by which the FDA eventually
      clears, approves, or licenses such products for marketing in the United States
      will be referred to as approval. This report summarizes the various ways medical 
      products, primarily medical devices, can legally be brought to market in the
      United States, and includes a discussion of the approval process, along with
      manufacturers' responsibilities, labeling, marketing and promotion, and off-label
      use. This is an educational and descriptive report and does not contain
      prescriptive recommendations. This report addresses the role of the medical
      physicist in clinical situations involving off-label use. Case studies in
      radiation therapy are presented. Any mention of commercial products is for
      identification only; it does not imply recommendations or endorsements of any of 
      the authors or the AAPM. The full report, containing extensive background on
      off-label use with several appendices, is available on the AAPM website
      (http://www.aapm.org/pubs/reports/).
FAU - Thomadsen, Bruce R
AU  - Thomadsen BR
AD  - Department of Medical Physics, University of Wisconsin, Madison, Wisconsin 53705,
      USA. thomadsen@humonc.wisc.edu
FAU - Heaton, H Thompson 2nd
AU  - Heaton HT 2nd
FAU - Jani, Shirish K
AU  - Jani SK
FAU - Masten, Jeffery P
AU  - Masten JP
FAU - Napolitano, Mary E
AU  - Napolitano ME
FAU - Ouhib, Zoubir
AU  - Ouhib Z
FAU - Reft, Chester S
AU  - Reft CS
FAU - Rivard, Mark J
AU  - Rivard MJ
FAU - Robin, T Tydings
AU  - Robin TT
FAU - Subramanian, Manny
AU  - Subramanian M
FAU - Suleiman, Orhan H
AU  - Suleiman OH
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Phys
JT  - Medical physics
JID - 0425746
SB  - IM
MH  - *Advisory Committees
MH  - Brachytherapy/instrumentation
MH  - *Equipment and Supplies
MH  - Humans
MH  - Liability, Legal
MH  - Microspheres
MH  - Neoplasms/therapy
MH  - Off-Label Use/*legislation & jurisprudence/statistics & numerical data
MH  - Radiotherapy/*instrumentation
MH  - Reimbursement Mechanisms/legislation & jurisprudence
MH  - *Societies, Scientific
MH  - United States
MH  - United States Food and Drug Administration/*legislation & jurisprudence
EDAT- 2010/06/10 06:00
MHDA- 2010/06/29 06:00
CRDT- 2010/06/10 06:00
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2010/06/29 06:00 [medline]
AID - 10.1118/1.3392286 [doi]
PST - ppublish
SO  - Med Phys. 2010 May;37(5):2300-11. doi: 10.1118/1.3392286.


PMID- 20527504
OWN - NLM
STAT- MEDLINE
DCOM- 20100722
LR  - 20131121
IS  - 0895-8831 (Print)
IS  - 0895-8831 (Linking)
VI  - 21
IP  - 1
DP  - 2010
TI  - The use of the Modified Gingival Margin Plaque Index (MGMPI) method to
      investigate the inhibitory effect of various toothpastes on dental plaque
      formation.
PG  - 1-3
AB  - OBJECTIVE: Colgate Total (CTT) is the only FDA-approved toothpaste for antiplaque
      and antigingivitis benefits. The objective of this study was to compare the
      impact of Colgate Total Pharma (CTP), a new variant of Colgate Total, with
      Colgate Regular Toothpaste (CRT) on plaque formation over a 24-hour period
      following a single use of the dentifrice. METHODS: CTP and CRT were the two test 
      products. CRT was used for a washout product as well. Fifteen male/female
      subjects who met the inclusion/exclusion criteria were included into this
      single-blind (preliminary phase) and double-blind (randomized phase) crossover
      study. Ethical approval and written informed consent were obtained. Preliminary
      phase: After a one-week washout with CRT, subjects brushed in the dental clinic
      with CRT before a one-minute use of a test dentifrice. A baseline Modified
      Gingival Margin Plaque Index (MGMPI) score was calculated. Subjects refrained
      from oral hygiene for 24 hours, and returned to the clinic for their 24-hour
      MGMPI score. Subjects entered the second washout phase to repeat as per the
      crossover design. The above procedures were conducted three times by three
      independent examiners. Randomized phase: Subjects were randomized to the groups
      according to a computer-generated randomization schedule. The procedure was
      carried out as in the preliminary phase, except the washout period between the
      two products was at least one week and the products (CTP or CRT) were used in a
      randomized double-blind manner. Plaque scores were recorded as above. RESULTS:
      CTP provided a significant (p = 0.01) antiplaque effect versus CRT. The results
      are consistent with previously reported data for CTT. All three examiners
      demonstrated a strong correlation for this clinical study utilizing the MGMPI
      methodology. CONCLUSION: This clinical investigation examined the efficacy of a
      new variant of a commercial dentifrice, historically shown to provide antiplaque 
      and antigingivitis efficacy. It is important to confirm the continued efficacy of
      new products to consumers and to the profession. Additionally, this clinical
      trial demonstrated the usefulness of the clinical methodology with respect to
      consistency in results by three independent clinical examiners. Because this
      methodology is often employed to document antiplaque benefits of new and existing
      technologies, it is important to periodically evaluate and confirm its
      reliability and reproducibility.
FAU - Moazzez, Rebecca
AU  - Moazzez R
AD  - Department of Restorative Dentistry King's College London Dental Institute at
      Guy's, King's and St. Thomas' Dental Hospitals, London, England.
FAU - Booth, Veronica
AU  - Booth V
FAU - Barnes, Virginia Monsul
AU  - Barnes VM
FAU - Richter, Rose
AU  - Richter R
FAU - Xu, Tao
AU  - Xu T
FAU - DeVizio, William
AU  - DeVizio W
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Dent
JT  - The Journal of clinical dentistry
JID - 8904411
RN  - 0 (Complex Mixtures)
RN  - 0 (Dentifrices)
RN  - 0 (Pharmaceutic Aids)
RN  - 0 (Toothpastes)
RN  - 0 (hydrated silica gel-based toothpaste)
RN  - 1343-98-2 (Silicic Acid)
RN  - 4NM5039Y5X (Triclosan)
RN  - 7631-86-9 (Silicon Dioxide)
RN  - 8ZYQ1474W7 (Sodium Fluoride)
RN  - PDC6A3C0OX (Glycerol)
RN  - Q80VPU408O (Fluorides)
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Chemistry, Pharmaceutical
MH  - Complex Mixtures/therapeutic use
MH  - Cross-Over Studies
MH  - Dental Plaque/*prevention & control
MH  - *Dental Plaque Index
MH  - Dentifrices/therapeutic use
MH  - Double-Blind Method
MH  - Female
MH  - Fluorides/therapeutic use
MH  - Follow-Up Studies
MH  - Glycerol/chemistry
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pharmaceutic Aids/chemistry
MH  - Silicic Acid
MH  - Silicon Dioxide/therapeutic use
MH  - Single-Blind Method
MH  - Sodium Fluoride/therapeutic use
MH  - Toothpastes/chemistry/*therapeutic use
MH  - Triclosan/therapeutic use
MH  - Young Adult
EDAT- 2010/06/10 06:00
MHDA- 2010/07/23 06:00
CRDT- 2010/06/10 06:00
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2010/07/23 06:00 [medline]
PST - ppublish
SO  - J Clin Dent. 2010;21(1):1-3.


PMID- 20527454
OWN - NLM
STAT- MEDLINE
DCOM- 20100813
LR  - 20100609
IS  - 1354-5752 (Print)
IS  - 1354-5752 (Linking)
VI  - 18
IP  - 2
DP  - 2010 May
TI  - Exploring the ethics of prescribing medicines.
PG  - 24-6
AB  - The delivery of holistic care should incorporate patient empowerment through the 
      promotion of health and self-help measures, including pain relief. In this
      article, the author, a newly qualified independent prescriber, explains why she
      believes that encouraging patients to buy over-the-counter medication is morally 
      acceptable and based on the principles of beneficence and non-malevolence. She
      also reflects on her prescribing decisions in the context of ethics, health
      economics and personal perspective for four patients with similar injuries. The
      author works in Wales, where prescriptions are free to residents.
FAU - Jackson, Jan
AU  - Jackson J
AD  - Royal Gwent Hospital, Newport.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Emerg Nurse
JT  - Emergency nurse : the journal of the RCN Accident and Emergency Nursing
      Association
JID - 9208913
RN  - 0 (Nonprescription Drugs)
MH  - Adult
MH  - Aged
MH  - Decision Making
MH  - Drug Prescriptions/*nursing
MH  - Emergency Nursing/*ethics
MH  - *Ethics, Nursing
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nonprescription Drugs
MH  - Nurse's Role
MH  - Pain/nursing/*prevention & control
MH  - Pain Measurement
MH  - Professional Autonomy
EDAT- 2010/06/10 06:00
MHDA- 2010/08/14 06:00
CRDT- 2010/06/10 06:00
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2010/08/14 06:00 [medline]
AID - 10.7748/en2010.05.18.2.24.c7756 [doi]
PST - ppublish
SO  - Emerg Nurse. 2010 May;18(2):24-6. doi: 10.7748/en2010.05.18.2.24.c7756.


PMID- 20527340
OWN - NLM
STAT- MEDLINE
DCOM- 20100629
LR  - 20191111
IS  - 0034-9356 (Print)
IS  - 0034-9356 (Linking)
VI  - 57
IP  - 5
DP  - 2010 May
TI  - [Maternal hypotension with low doses of spinal bupivacaine or levobupivacaine and
      epidural volume expansion with saline for cesarean section].
PG  - 267-74
AB  - BACKGROUND AND OBJECTIVE: Epidural volume extension (EVE) with saline solution
      can contribute to greater cephalad spread of drugs injected into the subarachnoid
      space during cesarean section. We studied the incidence of material hypotension
      with spinal bupivacaine or levobupivacaine (L-bupivacaine) and the spread after
      epidural saline injection. MATERIAL AND METHODS: After ethics committee approval,
      we randomized women scheduled for cesarean section to 4 groups to receive 5 mg of
      0.25% bupivacaine with (n=51) or without (n=6) saline EVE; 5 mg of 025%
      L-bupivacaine (n=50); or 6 mg of 03% L-bupivacaine (n=50). All patients also
      received 25 microg of fentanyl per 2 mL of local hyperbaric spinal anesthetic. In
      all except the non-EVE group, 10 mL of saline was infused through an epidural
      catheter 5 minutes after anesthetic infusion. We recorded patient demographic
      data, procedural and anesthetic times, incision-clamping times, occurrence of
      hypotension, ephedrine dose required, motor and sensory blockade, requirement for
      rescue analgesics, and neonatal outcome. RESULTS: After 6 patients had been
      randomized to the non-EVE group, no further patients were assigned because all
      the women required rescue analgesics. Demographic data, duration of procedure,
      time between. incision and delivery, and Apgar scores were similar in all the
      groups. The incidence of hypotension was lower in the group receiving 5 mg of
      L-bupivacaine (26% vs. 52.9% in the bupivacaine 5-mg group, and 56% in the 6-mg
      L-bupivacaine group, P = .04). More women given 5 mg of L-bupivacaine required
      rescue analgesia (46%) than did those receiving 5 mg of bupivacaine (235%) or 6
      mg of L-bupivacaine (28%) (P = .039). Hypotension was associated with a lower
      umbilical cord pH (P = .001). Ephedrine doses over 20 mg were also associated
      with a lower umbilical cord pH (P = .031). CONCLUSIONS: The incidence of
      hypotension was lowest in the group anesthetized with 5 mg of L-bupivacaine, but 
      the need for rescue analgesia was greater in this group. Doses of 5 mg and 6 mg
      may be sufficient for cesarean section, as they provide a good level of sensory
      blockade.
FAU - Guasch, E
AU  - Guasch E
AD  - Servicio de Anestesiologia, Reanimacion y Terapia del Dolor, Hospital
      Universitario La Paz, Madrid. emiguasch@hotmail.com
FAU - Gilsanz, F
AU  - Gilsanz F
FAU - Diez, J
AU  - Diez J
FAU - Alsina, E
AU  - Alsina E
LA  - spa
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
TT  - Hipotension arterial materna con dosis bajas de bupi y levo- bupivacaina
      intradural para cesarea mas extension epidural con salino.
PL  - Spain
TA  - Rev Esp Anestesiol Reanim
JT  - Revista espanola de anestesiologia y reanimacion
JID - 0134516
RN  - 0 (Anesthetics, Local)
RN  - 451W47IQ8X (Sodium Chloride)
RN  - A5H73K9U3W (Levobupivacaine)
RN  - GN83C131XS (Ephedrine)
RN  - Y8335394RO (Bupivacaine)
SB  - IM
MH  - Acidosis/blood
MH  - Adult
MH  - Analgesia, Epidural/methods
MH  - Analgesia, Obstetrical/methods
MH  - Anesthesia, Epidural/*methods
MH  - Anesthetics, Local/administration & dosage/*adverse effects/pharmacokinetics
MH  - Bupivacaine/administration & dosage/*adverse effects/analogs &
      derivatives/pharmacokinetics
MH  - *Cesarean Section
MH  - Ephedrine/therapeutic use
MH  - Female
MH  - Fetal Blood/chemistry
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Hypotension/*chemically induced/drug therapy
MH  - Infant, Newborn
MH  - Levobupivacaine
MH  - Obstetric Labor Complications/*chemically induced/drug therapy
MH  - Pregnancy
MH  - Pressure
MH  - Sodium Chloride/administration & dosage/*adverse effects
MH  - Subarachnoid Space
EDAT- 2010/06/10 06:00
MHDA- 2010/06/30 06:00
CRDT- 2010/06/10 06:00
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2010/06/30 06:00 [medline]
AID - S0034-9356(10)70226-7 [pii]
AID - 10.1016/s0034-9356(10)70226-7 [doi]
PST - ppublish
SO  - Rev Esp Anestesiol Reanim. 2010 May;57(5):267-74. doi:
      10.1016/s0034-9356(10)70226-7.


PMID- 20527320
OWN - NLM
STAT- MEDLINE
DCOM- 20100614
LR  - 20220310
IS  - 0306-3127 (Print)
IS  - 0306-3127 (Linking)
VI  - 40
IP  - 2
DP  - 2010 Apr
TI  - Bioethics and the reinforcement of socio-technical expectations.
PG  - 163-86
AB  - Over the past few years, considerable interest has been paid to the way in which 
      social expectations (hopes, hypes, fears) about new genomic technologies help
      shape, and in themselves are shaped by, emerging technologies, regulatory regimes
      and social concerns. In comparison, little attention has been paid to the role of
      expectations in related, but non-scientific discourses, such as bioethics.
      Drawing on a review of publications addressing the ethical issues associated with
      pharmacogenetics, this paper presents a detailed critique of bioethicists'
      contribution to these debates. The review highlights how, almost a decade after
      bioethical debate around pharmacogenetics started, and in contrast to the
      profession's self-perception as a form of regulator, bioethicists still largely
      restrict themselves to reviews of possible ethical issues raised by this
      technology, rather than critiquing others' positions and arguing for specific
      points of view. In addition the paper argues that bioethicists tend to: accept
      unquestioningly scientists' expectations about the development and ethical issues
      raised by pharmacogenetics; ignore contributions from bioethicists who do
      question these expectations; and engage in an ethical debate, the boundaries of
      which have been laid down and defined by academic and industry scientists. The
      paper concludes by offering some possible explanations for why the bioethical
      discourse has taken this form.
FAU - Hedgecoe, Adam
AU  - Hedgecoe A
AD  - Cesagen School of Social Science, Cardiff University, UK.
      HedgecoeAM@cardiff.ac.uk
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Soc Stud Sci
JT  - Social studies of science
JID - 7506743
MH  - *Bioethical Issues
MH  - Bioethics/trends
MH  - Humans
MH  - Pharmacogenetics/*ethics
MH  - *Sociology, Medical
RF  - 82
EDAT- 2010/06/10 06:00
MHDA- 2010/06/15 06:00
CRDT- 2010/06/10 06:00
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2010/06/15 06:00 [medline]
AID - 10.1177/0306312709349781 [doi]
PST - ppublish
SO  - Soc Stud Sci. 2010 Apr;40(2):163-86. doi: 10.1177/0306312709349781.


PMID- 20527318
OWN - NLM
STAT- MEDLINE
DCOM- 20100708
LR  - 20170214
IS  - 0840-4704 (Print)
IS  - 0840-4704 (Linking)
VI  - 23
IP  - 1
DP  - 2010 Spring
TI  - Ethics and the procurement process: meeting expectations.
PG  - 38-43
FAU - Baird, Kenneth W
AU  - Baird KW
FAU - Dibert, Stephen
AU  - Dibert S
LA  - eng
LA  - fre
PT  - Journal Article
PL  - United States
TA  - Healthc Manage Forum
JT  - Healthcare management forum
JID - 8805307
MH  - Conflict of Interest/*economics
MH  - Humans
MH  - Purchasing, Hospital/*ethics
EDAT- 2010/06/10 06:00
MHDA- 2010/07/09 06:00
CRDT- 2010/06/10 06:00
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2010/07/09 06:00 [medline]
AID - 10.1016/j.hcmf.2010.01.002 [doi]
PST - ppublish
SO  - Healthc Manage Forum. 2010 Spring;23(1):38-43. doi: 10.1016/j.hcmf.2010.01.002.


PMID- 20526984
OWN - NLM
STAT- MEDLINE
DCOM- 20100929
LR  - 20100607
IS  - 1098-9056 (Electronic)
IS  - 0734-0478 (Linking)
VI  - 31
IP  - 2
DP  - 2010 May
TI  - The tools of our trade: ethics, outcomes, and effects of therapeutic discourse.
      Preface.
PG  - 77-9
LID - 10.1055/s-0030-1252108 [doi]
FAU - Hinckley, Jacqueline
AU  - Hinckley J
AD  - Communication Sciences & Disorders, University of South Florida, Tampa, Florida, 
      USA.
LA  - eng
PT  - Introductory Journal Article
DEP - 20100602
PL  - United States
TA  - Semin Speech Lang
JT  - Seminars in speech and language
JID - 8405117
SB  - IM
MH  - Communication
MH  - Humans
MH  - Language Disorders/therapy
MH  - Language Therapy/*ethics/*methods
MH  - *Patient-Centered Care/ethics/methods
MH  - Professional-Patient Relations/*ethics
MH  - *Speech-Language Pathology/ethics/methods
MH  - Treatment Outcome
EDAT- 2010/06/09 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/06/08 06:00
PHST- 2010/06/08 06:00 [entrez]
PHST- 2010/06/09 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - 10.1055/s-0030-1252108 [doi]
PST - ppublish
SO  - Semin Speech Lang. 2010 May;31(2):77-9. doi: 10.1055/s-0030-1252108. Epub 2010
      Jun 2.


PMID- 20526970
OWN - NLM
STAT- MEDLINE
DCOM- 20100712
LR  - 20100607
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 6
DP  - 2010 Jun
TI  - One size does not fit all: toward "upstream ethics"?
PG  - 42-4
LID - 10.1080/15265161.2010.482639 [doi]
FAU - Ozdemir, Vural
AU  - Ozdemir V
AD  - Department of Social and Preventive Medicine, School of Public Health, University
      of Montreal, C.P. 6128, Succ. Centre-ville, Montreal, Qeebec H3C3J7, Canada.
      vural.ozdemir@umontreal.ca
FAU - Knoppers, Bartha Maria
AU  - Knoppers BM
LA  - eng
GR  - R0016158/Canadian Institutes of Health Research/Canada
PT  - Comment
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
RN  - 0 (Reagent Kits, Diagnostic)
SB  - IM
CON - Am J Bioeth. 2010 Jun;10(6):26-35. PMID: 20526966
MH  - Biomedical Research/economics/ethics
MH  - Biomedical Technology/*economics/*ethics/standards
MH  - Clinical Trials as Topic/economics/ethics
MH  - Developing Countries/*economics
MH  - Ethics, Research
MH  - Health Care Sector/economics/ethics
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - *International Cooperation
MH  - Metagenomics
MH  - Multicenter Studies as Topic/economics/ethics
MH  - *Reagent Kits, Diagnostic/economics/ethics/standards
MH  - Research Support as Topic/*ethics
MH  - Sensitivity and Specificity
EDAT- 2010/06/09 06:00
MHDA- 2010/07/14 06:00
CRDT- 2010/06/08 06:00
PHST- 2010/06/08 06:00 [entrez]
PHST- 2010/06/09 06:00 [pubmed]
PHST- 2010/07/14 06:00 [medline]
AID - 922719164 [pii]
AID - 10.1080/15265161.2010.482639 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Jun;10(6):42-4. doi: 10.1080/15265161.2010.482639.


PMID- 20526965
OWN - NLM
STAT- MEDLINE
DCOM- 20100712
LR  - 20100607
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 6
DP  - 2010 Jun
TI  - Is there a case for a distinction between ethics and policy?
PG  - 24-5
LID - 10.1080/15265161003754031 [doi]
FAU - Hunter, David
AU  - Hunter D
AD  - Centre for Professional Ethics, Keele University, Keele, Newcastle-Under-Lyme
      ST55BG, United Kingdom. d.hunter@peak.keele.ac.uk
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2010 Jun;10(6):3-13. PMID: 20526958
MH  - Clinical Trials as Topic/ethics
MH  - *Ethics
MH  - *Ethics, Research
MH  - Evidence-Based Medicine/ethics
MH  - *Health Policy
MH  - Human Experimentation/ethics
MH  - Humans
MH  - *Policy Making
EDAT- 2010/06/09 06:00
MHDA- 2010/07/14 06:00
CRDT- 2010/06/08 06:00
PHST- 2010/06/08 06:00 [entrez]
PHST- 2010/06/09 06:00 [pubmed]
PHST- 2010/07/14 06:00 [medline]
AID - 922729067 [pii]
AID - 10.1080/15265161003754031 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Jun;10(6):24-5. doi: 10.1080/15265161003754031.


PMID- 20526963
OWN - NLM
STAT- MEDLINE
DCOM- 20100712
LR  - 20100607
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 6
DP  - 2010 Jun
TI  - A third way: ethics guidance as evidence-informed provisional rules.
PG  - 20-2
LID - 10.1080/15265161003702881 [doi]
FAU - Borgerson, Kirstin
AU  - Borgerson K
AD  - Department of Philosophy, Dalhousie University, Halifax, Nova Scotia B3H4P9
      Canada. kirstin.borgerson@dal.ca
FAU - Millum, Joseph
AU  - Millum J
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2010 Jun;10(6):3-13. PMID: 20526958
MH  - *Ethics Committees, Research/ethics
MH  - Ethics, Research
MH  - Evidence-Based Medicine/*ethics
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Randomized Controlled Trials as Topic/*ethics
MH  - Research Design/*standards
EDAT- 2010/06/09 06:00
MHDA- 2010/07/14 06:00
CRDT- 2010/06/08 06:00
PHST- 2010/06/08 06:00 [entrez]
PHST- 2010/06/09 06:00 [pubmed]
PHST- 2010/07/14 06:00 [medline]
AID - 922732035 [pii]
AID - 10.1080/15265161003702881 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Jun;10(6):20-2. doi: 10.1080/15265161003702881.


PMID- 20526960
OWN - NLM
STAT- MEDLINE
DCOM- 20100712
LR  - 20211020
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 6
DP  - 2010 Jun
TI  - Ethical rules for human subjects research: a case where the "is" must inform the 
      "ought".
PG  - 14-5
LID - 10.1080/15265161003728829 [doi]
FAU - Kon, Alexander A
AU  - Kon AA
AD  - Department of Pediatrics, University of California Davis, 2516 Stockton Blvd.,
      Sacramento, CA 95817, USA. aakon@ucdavis.edu
LA  - eng
GR  - UL1 RR024146/RR/NCRR NIH HHS/United States
GR  - UL1 RR024146-04/RR/NCRR NIH HHS/United States
PT  - Comment
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2010 Jun;10(6):3-13. PMID: 20526958
MH  - Choice Behavior/*ethics
MH  - Clinical Trials as Topic/*ethics
MH  - Coercion
MH  - Ethics
MH  - *Ethics Committees, Research
MH  - Ethics, Research
MH  - Evidence-Based Medicine/ethics
MH  - Health Policy
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - *Policy Making
MH  - *Research Subjects/economics
MH  - Researcher-Subject Relations/ethics
MH  - *Salaries and Fringe Benefits
MH  - United States
PMC - PMC2882624
MID - NIHMS195479
EDAT- 2010/06/09 06:00
MHDA- 2010/07/14 06:00
CRDT- 2010/06/08 06:00
PHST- 2010/06/08 06:00 [entrez]
PHST- 2010/06/09 06:00 [pubmed]
PHST- 2010/07/14 06:00 [medline]
AID - 922718279 [pii]
AID - 10.1080/15265161003728829 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Jun;10(6):14-5. doi: 10.1080/15265161003728829.


PMID- 20526958
OWN - NLM
STAT- MEDLINE
DCOM- 20100712
LR  - 20100607
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 6
DP  - 2010 Jun
TI  - The case for evidence-based rulemaking in human subjects research.
PG  - 3-13
LID - 10.1080/15265161003702857 [doi]
AB  - Here I inquire into the status of the rules promulgated in the canonical
      pronouncements on human subjects research, such as the Declaration of Helsinki
      and the Belmont Report. The question is whether they are ethical rules or rules
      of policy. An ethical rule is supposed to accurately reflect the ethical fact
      (the fact that the action the rule prescribes is ethically obligatory), whereas
      rules of policy are implemented to achieve a goal. We should be skeptical, I
      argue, that the actions prescribed by the rules are ethically obligatory, and
      consequently we should focus our attention on how to craft the rules so as to
      promote the legitimate goals of human subjects research. Unfortunately, this
      cannot be done without evidence about the likely effects of various candidate
      policies-evidence we currently lack. Therefore, we should take the rules as mere 
      starting points, subject to revision as the evidence comes in.
FAU - Sachs, Benjamin
AU  - Sachs B
AD  - Environmental Studies and Bioethics, New York University, 285 Mercer 9th Floor,
      New York, NY, 10003, USA. sachs@nyu.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CIN - Am J Bioeth. 2010 Jun;10(6):1-2. PMID: 20526956
CIN - Am J Bioeth. 2010 Jun;10(6):W1-3. PMID: 20526957
CIN - Am J Bioeth. 2010 Jun;10(6):14-5. PMID: 20526960
CIN - Am J Bioeth. 2010 Jun;10(6):15-7. PMID: 20526961
CIN - Am J Bioeth. 2010 Jun;10(6):18-9. PMID: 20526962
CIN - Am J Bioeth. 2010 Jun;10(6):20-2. PMID: 20526963
CIN - Am J Bioeth. 2010 Jun;10(6):22-3. PMID: 20526964
CIN - Am J Bioeth. 2010 Jun;10(6):24-5. PMID: 20526965
MH  - Choice Behavior/ethics
MH  - Clinical Trials as Topic/*ethics
MH  - *Codes of Ethics
MH  - Coercion
MH  - Ethics
MH  - *Ethics, Research
MH  - Evidence-Based Medicine/*ethics
MH  - Health Policy
MH  - Health Services Accessibility
MH  - Helsinki Declaration
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Informed Consent/ethics
MH  - Patient Dropouts
MH  - *Patient Rights
MH  - *Policy Making
MH  - Practice Guidelines as Topic/standards
MH  - Research Design/standards
MH  - *Research Subjects/economics
MH  - Researcher-Subject Relations/*ethics
MH  - Risk-Taking
MH  - Salaries and Fringe Benefits
MH  - Terminology as Topic
MH  - United States
EDAT- 2010/06/09 06:00
MHDA- 2010/07/14 06:00
CRDT- 2010/06/08 06:00
PHST- 2010/06/08 06:00 [entrez]
PHST- 2010/06/09 06:00 [pubmed]
PHST- 2010/07/14 06:00 [medline]
AID - 922717977 [pii]
AID - 10.1080/15265161003702857 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Jun;10(6):3-13. doi: 10.1080/15265161003702857.


PMID- 20526956
OWN - NLM
STAT- MEDLINE
DCOM- 20100712
LR  - 20100607
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 6
DP  - 2010 Jun
TI  - Ethical rules, policies, or guidance?
PG  - 1-2
LID - 10.1080/15265161003686555 [doi]
FAU - Macklin, Ruth
AU  - Macklin R
LA  - eng
PT  - Comment
PT  - Editorial
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2010 Jun;10(6):3-13. PMID: 20526958
MH  - Codes of Ethics
MH  - *Ethics
MH  - *Ethics, Research
MH  - Evidence-Based Medicine/ethics
MH  - *Health Policy
MH  - Helsinki Declaration
MH  - Humans
MH  - *Patient Rights
MH  - Practice Guidelines as Topic
MH  - *Research Subjects
MH  - United States
MH  - United States Food and Drug Administration
EDAT- 2010/06/09 06:00
MHDA- 2010/07/14 06:00
CRDT- 2010/06/08 06:00
PHST- 2010/06/08 06:00 [entrez]
PHST- 2010/06/09 06:00 [pubmed]
PHST- 2010/07/14 06:00 [medline]
AID - 922732176 [pii]
AID - 10.1080/15265161003686555 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Jun;10(6):1-2. doi: 10.1080/15265161003686555.


PMID- 20526117
OWN - NLM
STAT- MEDLINE
DCOM- 20100902
LR  - 20100607
IS  - 1538-9782 (Electronic)
IS  - 0887-6274 (Linking)
VI  - 24
IP  - 4
DP  - 2010 Jul-Aug
TI  - A model for ethical decision making in cases of patient futility.
PG  - 189-90
LID - 10.1097/NUR.0b013e3181e360ac [doi]
FAU - Clark, Angela P
AU  - Clark AP
AD  - School of Nursing, The University of Texas at Austin, Austin, TX 78701, USA.
      apclark@mail.utexas.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Nurse Spec
JT  - Clinical nurse specialist CNS
JID - 8709115
MH  - Advance Directives/legislation & jurisprudence
MH  - *Decision Making
MH  - *Ethics, Nursing
MH  - Euthanasia, Passive
MH  - *Models, Theoretical
EDAT- 2010/06/09 06:00
MHDA- 2010/09/03 06:00
CRDT- 2010/06/08 06:00
PHST- 2010/06/08 06:00 [entrez]
PHST- 2010/06/09 06:00 [pubmed]
PHST- 2010/09/03 06:00 [medline]
AID - 10.1097/NUR.0b013e3181e360ac [doi]
AID - 00002800-201007000-00005 [pii]
PST - ppublish
SO  - Clin Nurse Spec. 2010 Jul-Aug;24(4):189-90. doi: 10.1097/NUR.0b013e3181e360ac.


PMID- 20525421
OWN - NLM
STAT- MEDLINE
DCOM- 20111005
LR  - 20191210
IS  - 1486-3847 (Print)
IS  - 1486-3847 (Linking)
VI  - 71
IP  - 2
DP  - 2010 Summer
TI  - Photovoice and its potential use in nutrition and dietetic research.
PG  - 93-7
AB  - Photovoice is an innovative qualitative method of participatory action research
      based on health promotion principles; however, it has not been used to its full
      potential in health care, particularly in nutrition and dietetics. Photovoice is 
      also based upon the theoretical literature on education for critical
      consciousness, feminist theory, and community-based approaches to documentary
      photography. Participants take photographs representing their views on a specific
      topic and discuss them in a group process of critical reflection. Originally
      designed for research with rural women, Photovoice has been used with a variety
      of population groups throughout the lifespan, such as adolescents, nurses and
      nursing students, professional groups, Aboriginal women, the elderly, immigrant
      and low-income groups, and patients with a variety of diseases. The use of
      Photovoice as a research method is not restricted by health conditions, financial
      situation, employment status, or literacy level. It is used in community
      settings, professional practice, or institutional learning environments to
      explore participants' views and opinions. We review studies in which Photovoice
      has been used, as well as the impacts, advantages, limitations, and ethics of its
      use. Gaps in knowledge and its potential use in nutrition and dietetic research
      are identified.
FAU - Martin, Noelle
AU  - Martin N
AD  - Brescia University College, University of Western Ontario, London, ON, Canada.
FAU - Garcia, Alicia C
AU  - Garcia AC
FAU - Leipert, Beverly
AU  - Leipert B
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Canada
TA  - Can J Diet Pract Res
JT  - Canadian journal of dietetic practice and research : a publication of Dietitians 
      of Canada = Revue canadienne de la pratique et de la recherche en dietetique :
      une publication des Dietetistes du Canada
JID - 9811151
SB  - IM
MH  - Biomedical Research/*methods
MH  - Communication
MH  - Dietetics/*education
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - *Health Promotion
MH  - Humans
MH  - Male
MH  - Nutritional Sciences/*education
MH  - Photography
MH  - Power, Psychological
EDAT- 2010/06/09 06:00
MHDA- 2011/10/06 06:00
CRDT- 2010/06/08 06:00
PHST- 2010/06/08 06:00 [entrez]
PHST- 2010/06/09 06:00 [pubmed]
PHST- 2011/10/06 06:00 [medline]
AID - 10.3148/71.2.2010.93 [doi]
PST - ppublish
SO  - Can J Diet Pract Res. 2010 Summer;71(2):93-7. doi: 10.3148/71.2.2010.93.


PMID- 20525417
OWN - NLM
STAT- MEDLINE
DCOM- 20111005
LR  - 20161125
IS  - 1486-3847 (Print)
IS  - 1486-3847 (Linking)
VI  - 71
IP  - 2
DP  - 2010 Summer
TI  - Perceived facilitators of and barriers to healthful eating among university
      students.
PG  - e28-33
AB  - PURPOSE: Photovoice, an innovative qualitative research method in health care,
      has not been used to its full potential in nutrition/dietetics. We explored the
      use of Photovoice to determine perceived facilitators of and barriers to
      healthful eating among university students. METHODS: The study included 28
      students enrolled in a 2008 introductory nutrition class. The students
      participated in a camera orientation session to review ethics and privacy issues.
      They took photographs and selected two for discussion in a focus group moderated 
      by a graduate student who used a semi-structured facilitation guide. Researchers 
      coded the transcripts, analyzed the pictures and students' written comments about
      the project, and ensured data trustworthiness through credibility, dependability,
      confirmability, and transferability of data and methods. RESULTS: Six major
      themes emerged as facilitators and/or barriers: environment, nutrition knowledge,
      convenience foods, time, media influence, and food cost. More than one-third of
      the students thought the study "stimulated their critical thinking." They felt
      more empowered in sharing their perceptions and "getting their voices heard."
      CONCLUSIONS: Photovoice was a useful, "motivating," and "engaging" method for
      research on nutrition knowledge and dietary patterns of university students.
      Registered dietitians and other health professionals may benefit from the use of 
      the Photovoice method when they are working with students.
FAU - Garcia, Alicia C
AU  - Garcia AC
AD  - Division of Food and Nutritional Sciences, Brescia University College, University
      of Western Ontario, London, Ontario, Canada.
FAU - Sykes, Lesley
AU  - Sykes L
FAU - Matthews, June
AU  - Matthews J
FAU - Martin, Noelle
AU  - Martin N
FAU - Leipert, Beverly
AU  - Leipert B
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can J Diet Pract Res
JT  - Canadian journal of dietetic practice and research : a publication of Dietitians 
      of Canada = Revue canadienne de la pratique et de la recherche en dietetique :
      une publication des Dietetistes du Canada
JID - 9811151
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Diet/psychology
MH  - Feeding Behavior/psychology
MH  - Female
MH  - Focus Groups
MH  - Health Knowledge, Attitudes, Practice
MH  - *Health Promotion
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Ontario
MH  - Social Facilitation
MH  - Universities
MH  - Young Adult
EDAT- 2010/06/09 06:00
MHDA- 2011/10/06 06:00
CRDT- 2010/06/08 06:00
PHST- 2010/06/08 06:00 [entrez]
PHST- 2010/06/09 06:00 [pubmed]
PHST- 2011/10/06 06:00 [medline]
AID - 10.3148/71.2.2010.69 [doi]
PST - ppublish
SO  - Can J Diet Pract Res. 2010 Summer;71(2):e28-33. doi: 10.3148/71.2.2010.69.


PMID- 20524809
OWN - NLM
STAT- MEDLINE
DCOM- 20110209
LR  - 20181201
IS  - 1532-432X (Electronic)
IS  - 0363-0269 (Linking)
VI  - 34
IP  - 3
DP  - 2010 Jun
TI  - The 18th ICOC Proceedings in Athens, Greece: New breakthrough in thalassemia
      leading to the complete treatment of iron overload and to hundreds of patients
      achieving and maintaining normal body iron stores. Ethical questions on chelation
      therapy.
PG  - 199-203
LID - 10.3109/03630269.2010.484963 [doi]
AB  - A new era in thalassemia and other transfusional iron loading conditions was
      highlighted during the 18th International Conference on Chelation (ICOC) with
      reports that all excess iron accumulated from transfusions could be removed using
      the ICOC combination protocol of deferiprone (L1) (80-100 mg/kg/day) and
      subcutaneous deferoxamine (DFO) (40-60 mg/kg/day, at least 3 days per week), and 
      that normal range body iron store levels (NRBISL) could be maintained using L1
      monotherapy. Hundreds of patients in Cyprus, Greece, Italy, UK and elsewhere,
      maintain NRBISL, some for more than 9 years, and without complications. This gold
      standard of complete iron overload treatment is likely to change current
      practices, aims and protocols because it could prevent and also reverse cardiac, 
      liver, endocrine and other organ complications as well as the incidence of
      infections and hepatocellular carcinomas. The overall morbidity and mortality in 
      thalassemia and other transfusional iron loading conditions is expected to be
      substantially reduced. New applications of chelating drugs include renal,
      neurodegenerative, infectious diseases and ischemia reperfusion injury patients. 
      Ethical questions have been raised on the role of pharmaceutical companies, the
      clinicians and the Hippocratic oath in relation to chelation therapy.
FAU - Kontoghiorghes, George J
AU  - Kontoghiorghes GJ
AD  - Postgraduate Research Institute of Science, Technology, Environment and Medicine,
      Limassol, Cyprus. kontoghiorghes.g.j@pri.ac.cy
LA  - eng
PT  - Congress
PL  - England
TA  - Hemoglobin
JT  - Hemoglobin
JID - 7705865
RN  - 0 (Iron Chelating Agents)
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - Chelation Therapy/*ethics/methods
MH  - Greece
MH  - Humans
MH  - Iron/*metabolism
MH  - Iron Chelating Agents/administration & dosage/*therapeutic use
MH  - Iron Overload/diagnosis/*drug therapy
MH  - Thalassemia/*drug therapy
EDAT- 2010/06/09 06:00
MHDA- 2011/02/10 06:00
CRDT- 2010/06/08 06:00
PHST- 2010/06/08 06:00 [entrez]
PHST- 2010/06/09 06:00 [pubmed]
PHST- 2011/02/10 06:00 [medline]
AID - 10.3109/03630269.2010.484963 [doi]
PST - ppublish
SO  - Hemoglobin. 2010 Jun;34(3):199-203. doi: 10.3109/03630269.2010.484963.


PMID- 20524704
OWN - NLM
STAT- MEDLINE
DCOM- 20100816
LR  - 20211020
IS  - 1179-1969 (Electronic)
IS  - 1170-229X (Linking)
VI  - 27
IP  - 6
DP  - 2010 Jun 1
TI  - Withholding, discontinuing and withdrawing medications in dementia patients at
      the end of life: a neglected problem in the disadvantaged dying?
PG  - 435-49
LID - 10.2165/11536760-000000000-00000 [doi]
AB  - Recent years have seen a growing recognition that dementia is a terminal illness 
      and that patients with advanced dementia nearing the end of life do not currently
      receive adequate palliative care. However, research into palliative care for
      these patients has thus far been limited. Furthermore, there has been little
      discussion in the literature regarding medication use in patients with advanced
      dementia who are nearing the end of life, and discontinuation of medication has
      not been well studied despite its potential to reduce the burden on the patient
      and to improve quality of life. There is limited, and sometimes contradictory,
      evidence available in the literature to guide evidence-based discontinuation of
      drugs such as acetylcholinesterase inhibitors, antipsychotic agents, HMG-CoA
      reductase inhibitors (statins), antibacterials, antihypertensives,
      antihyperglycaemic drugs and anticoagulants. Furthermore, end-of-life care of
      patients with advanced dementia may be complicated by difficulties in accurately 
      estimating life expectancy, ethical considerations regarding withholding or
      withdrawing treatment, and the wishes of the patient and/or their family.
      Significant research must be undertaken in the area of medication discontinuation
      in patients with advanced dementia nearing the end of life to determine how
      physicians currently decide whether medications should be discontinued, and also 
      to develop the evidence base and provide guidance on systematic medication
      discontinuation.
FAU - Parsons, Carole
AU  - Parsons C
AD  - Clinical and Practice Research Group, School of Pharmacy, Queen's University
      Belfast, Belfast, Northern Ireland. c.parsons@qub.ac.uk
FAU - Hughes, Carmel M
AU  - Hughes CM
FAU - Passmore, A Peter
AU  - Passmore AP
FAU - Lapane, Kate L
AU  - Lapane KL
LA  - eng
PT  - Journal Article
PT  - Review
PL  - New Zealand
TA  - Drugs Aging
JT  - Drugs & aging
JID - 9102074
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Anticholesteremic Agents)
RN  - 0 (Antiparkinson Agents)
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Cholinesterase Inhibitors)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
RN  - 0 (Tranquilizing Agents)
SB  - IM
MH  - Anti-Bacterial Agents/therapeutic use
MH  - Anticholesteremic Agents/therapeutic use
MH  - Antiparkinson Agents/therapeutic use
MH  - Antipsychotic Agents/therapeutic use
MH  - Cholinesterase Inhibitors/therapeutic use
MH  - Dementia/*drug therapy
MH  - Enzyme Inhibitors/therapeutic use
MH  - Humans
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic use
MH  - Palliative Care
MH  - Polypharmacy
MH  - Terminal Care/*ethics
MH  - Tranquilizing Agents/therapeutic use
MH  - *Vulnerable Populations
MH  - Withholding Treatment/*ethics
RF  - 136
EDAT- 2010/06/09 06:00
MHDA- 2010/08/17 06:00
CRDT- 2010/06/08 06:00
PHST- 2010/06/08 06:00 [entrez]
PHST- 2010/06/09 06:00 [pubmed]
PHST- 2010/08/17 06:00 [medline]
AID - 1 [pii]
AID - 10.2165/11536760-000000000-00000 [doi]
PST - ppublish
SO  - Drugs Aging. 2010 Jun 1;27(6):435-49. doi: 10.2165/11536760-000000000-00000.


PMID- 20526985
OWN - NLM
STAT- MEDLINE
DCOM- 20100929
LR  - 20100607
IS  - 1098-9056 (Electronic)
IS  - 0734-0478 (Linking)
VI  - 31
IP  - 2
DP  - 2010 May
TI  - Person-centeredness, ethics, and stories of risk.
PG  - 81-9
LID - 10.1055/s-0030-1252109 [doi]
AB  - Storytelling can be a powerful way to reflect on the ethical issues that emerge
      in clinical practice. This article uses two stories by speech-language
      pathologists to explore how notions of person-centered practice may influence
      speech-language pathology practice. Then these stories are examined in relation
      to definitions of person-centered practice and speech pathology code of ethics to
      discuss the ethical issues, challenges, and risks that these stories raise.
      Moving toward more person-centered ways of practicing will require
      speech-language pathologists to be open to the real lives of their clients with
      communication and swallowing disabilities. It may also require speech-language
      pathologists to be open to their own vulnerabilities as well.
CI  - Thieme Medical Publishers.
FAU - O'Halloran, Robyn
AU  - O'Halloran R
AD  - The University of Queensland, Communication Disability Centre, School of Health
      and Rehabilitation Sciences, Bundoora, Australia. R.O'Halloran@latrobe.edu.au
FAU - Hersh, Deborah
AU  - Hersh D
FAU - Laplante-Levesque, Ariane
AU  - Laplante-Levesque A
FAU - Worrall, Linda
AU  - Worrall L
LA  - eng
PT  - Journal Article
DEP - 20100602
PL  - United States
TA  - Semin Speech Lang
JT  - Seminars in speech and language
JID - 8405117
SB  - IM
MH  - Communication Disorders/therapy
MH  - Deglutition Disorders/therapy
MH  - Female
MH  - Humans
MH  - *Language Therapy/ethics/methods
MH  - Middle Aged
MH  - *Patient-Centered Care/ethics/methods
MH  - Professional-Patient Relations
MH  - Risk
MH  - *Speech-Language Pathology/ethics/methods
EDAT- 2010/06/08 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/06/08 06:00
PHST- 2010/06/08 06:00 [entrez]
PHST- 2010/06/08 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - 10.1055/s-0030-1252109 [doi]
PST - ppublish
SO  - Semin Speech Lang. 2010 May;31(2):81-9. doi: 10.1055/s-0030-1252109. Epub 2010
      Jun 2.


PMID- 20526977
OWN - NLM
STAT- MEDLINE
DCOM- 20101129
LR  - 20100811
IS  - 1744-4144 (Electronic)
IS  - 1385-4046 (Linking)
VI  - 24
IP  - 6
DP  - 2010 Aug
TI  - Symptom validity issues in the psychological consultative examination for social 
      security disability.
PG  - 1045-63
LID - 10.1080/13854046.2010.481637 [doi]
AB  - This article is about Social Security Administration (SSA) policy with regard to 
      the Psychological Consultative Examination (PCE) for Social Security Disability, 
      particularly with respect to validation of the responses and findings. First, the
      nature of the consultation and the importance of understanding the boundaries and
      ethics of the psychologist's role are described. Issues particular to working
      with low-functioning claimants usually form a large part of these examinations.
      The psychologist must understand various forms of non-credible behavior during
      the PCE, and how malingering might be considered among other non-credible
      presentations. Issues pertaining to symptom validity testing in low-functioning
      claimants are further explored. SSA policy with respect to symptom validity
      testing is carefully examined, with an attempt to answer specific concerns and
      show how psychological science can be of assistance, particularly with
      evidence-based practice. Additionally, the nature and importance of techniques to
      avoid the mislabeling of claimants as malingerers are examined. SSA requires the 
      use of accepted diagnostic techniques with which to establish impairment, and
      this article describes the implementation of that requirement, particularly with 
      respect to validating the findings.
FAU - Chafetz, Michael D
AU  - Chafetz MD
AD  - ABPP, 3520 General DeGaulle Dr.#4098, New Orleans, LA 70131, USA.
      mikechaf@yahoo.com
LA  - eng
PT  - Journal Article
DEP - 20100602
PL  - England
TA  - Clin Neuropsychol
JT  - The Clinical neuropsychologist
JID - 8806548
SB  - IM
MH  - *Disability Evaluation
MH  - Disabled Persons
MH  - Eligibility Determination/standards
MH  - Humans
MH  - Malingering/*diagnosis/psychology
MH  - Referral and Consultation
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - *Social Security
MH  - United States
MH  - United States Social Security Administration
EDAT- 2010/06/08 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/06/08 06:00
PHST- 2010/06/08 06:00 [entrez]
PHST- 2010/06/08 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 922724219 [pii]
AID - 10.1080/13854046.2010.481637 [doi]
PST - ppublish
SO  - Clin Neuropsychol. 2010 Aug;24(6):1045-63. doi: 10.1080/13854046.2010.481637.
      Epub 2010 Jun 2.


PMID- 20526666
OWN - NLM
STAT- MEDLINE
DCOM- 20101130
LR  - 20151119
IS  - 1573-2770 (Electronic)
IS  - 0091-0562 (Linking)
VI  - 46
IP  - 1-2
DP  - 2010 Sep
TI  - "Big organisations" supporting "small involvement": lessons from Bosnia and
      Herzegovina on enabling community-based participation of children through par.
PG  - 204-14
LID - 10.1007/s10464-010-9322-0 [doi]
AB  - The article presents the process and the outcomes of child participatory action
      research (PAR) conducted in Bosnia and Herzegovina (BiH), as part of UNICEF
      activities in this country. The study was implemented through children acting as 
      co-researchers, organised in so-called Children's PAR Groups, initiated in three 
      BiH municipalities. Children collaborated with a Support Group in each of the
      municipalities, comprised of adults who helped children implement their
      activities. Children chose to focus their research on community participation and
      ensured a number of outcomes in a relatively brief period. The value of PAR in
      the development of child participation was highlighted by children and adults who
      took part in the study. Prejudices that children have toward adults, and vice
      versa, were issues identified as main barriers for wider children's
      participation. This article also reviews a number of ethical challenges
      highlighted in the study, such as the organisational barriers to children's
      participation and project-based support for its development.
FAU - Maglajlic, Reima Ana
AU  - Maglajlic RA
AD  - Swansea University, Wales, UK. R.A.Maglajlic@swansea.ac.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - Am J Community Psychol
JT  - American journal of community psychology
JID - 0364535
SB  - IM
MH  - Adult
MH  - Bosnia and Herzegovina
MH  - Child
MH  - *Community-Based Participatory Research/ethics/methods/organization &
      administration/standards
MH  - Humans
MH  - Self-Help Groups/organization & administration
MH  - United Nations/organization & administration
EDAT- 2010/06/08 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/06/08 06:00
PHST- 2010/06/08 06:00 [entrez]
PHST- 2010/06/08 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1007/s10464-010-9322-0 [doi]
PST - ppublish
SO  - Am J Community Psychol. 2010 Sep;46(1-2):204-14. doi: 10.1007/s10464-010-9322-0.


PMID- 20526463
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 0169-3867 (Print)
IS  - 0169-3867 (Linking)
VI  - 25
IP  - 2
DP  - 2010 Jan 6
TI  - Social values and scientific evidence: the case of the HPV vaccines.
PG  - 203-213
AB  - Several have argued that the aims of scientific research are not always
      independent of social and ethical values. Yet this is often assumed only to have 
      implications for decisions about what is studied, or which research projects are 
      funded, and not for methodological decisions or standards of evidence. Using the 
      case of the recently developed HPV vaccines, we argue that the social aims of
      research can also play important roles in justifying decisions about (1) how
      research problems are defined in drug development, (2) evidentiary standards used
      in testing drug "success", and (3) clinical trial methodology. As a result,
      attending to the social aims at stake in particular research contexts will
      produce more rational methodological decisions as well as more socially relevant 
      science.
FAU - Intemann, Kristen
AU  - Intemann K
AD  - Montana State University, Bozeman, MT, USA.
FAU - de Melo-Martin, Inmaculada
AU  - de Melo-Martin I
LA  - eng
GR  - P20 GM103474/GM/NIGMS NIH HHS/United States
GR  - P20 RR016455/RR/NCRR NIH HHS/United States
GR  - P20 RR016455-08/RR/NCRR NIH HHS/United States
GR  - P20 RR016455-09/RR/NCRR NIH HHS/United States
PT  - Journal Article
PL  - Netherlands
TA  - Biol Philos
JT  - Biology & philosophy
JID - 8607458
PMC - PMC2879703
MID - NIHMS190208
EDAT- 2010/06/08 06:00
MHDA- 2010/06/08 06:01
CRDT- 2010/06/08 06:00
PHST- 2010/06/08 06:00 [entrez]
PHST- 2010/06/08 06:00 [pubmed]
PHST- 2010/06/08 06:01 [medline]
AID - 10.1007/s10539-009-9191-9 [doi]
PST - ppublish
SO  - Biol Philos. 2010 Jan 6;25(2):203-213. doi: 10.1007/s10539-009-9191-9.


PMID- 20526184
OWN - NLM
STAT- MEDLINE
DCOM- 20100722
LR  - 20191210
IS  - 1528-1175 (Electronic)
IS  - 0003-3022 (Linking)
VI  - 113
IP  - 1
DP  - 2010 Jul
TI  - Skin conductance fluctuations correlate poorly with postoperative self-report
      pain measures in school-aged children.
PG  - 175-82
LID - 10.1097/ALN.0b013e3181de6ce9 [doi]
AB  - BACKGROUND: The number of fluctuations of skin conductance per second (NFSC) has 
      been shown to correlate with induced pain and self-report pain scales. This study
      aimed to evaluate the validity and feasibility of NFSC as an objective
      measurement of nociception intensity in school-aged children after surgery.
      METHODS: After approval by the research ethics board and obtaining consent, 100
      subjects participated in this prospective observational study. Preoperatively,
      NFSC was measured for 60 s at rest and during response to a self-report pain
      scale (numeric rating scale [NRS], Faces Pain Scale-Revised) and anxiety scoring 
      (NRS). Postoperative measurements were repeated every 10 min for 30 min or until 
      NRS pain score was <or= 4 for two consecutive scores. Spearman rank correlation
      coefficients were calculated to investigate the relationship between NFSC and NRS
      pain, Faces Pain Scale-Revised, and NRS anxiety. The clinical utility of using
      NFSC in determining NRS pain threshold was investigated using receiver operator
      characteristics analysis. For clinical relevance, a cutoff NFSC was chosen that
      optimizes both specificity and sensitivity. Although selecting a low cutoff value
      increases the sensitivity of the NFSC in diagnosing pain, it does so at the
      expense of specificity. RESULTS: Data from 90 subjects (64.4% male) aged 7-17 yr 
      (median age 13 yr) were analyzed (217 postoperative datasets). NFSC correlated
      weakly with NRS pain scores (P = 0.21; P < 0.002). NFSC did not correlate with
      NRS anxiety scores (P = 0.15, P < 0.03). NRS pain scores correlated strongly with
      Faces Pain Scale-Revised (P = 0.89, P < 0.0001) and weakly with NRS anxiety
      scores (P = 0.34, P < 0.0001). A threshold of 0.23 NFSC predicted severe pain
      (NRS >or= 7) with 56.3% sensitivity (95% CI = 37.7-73.6%) and 78.4% specificity
      (95% CI = 71.7-84.1%). The area under receiver operator characteristic curve for 
      NFSC was 69.1%. CONCLUSIONS: NFSC measurement is feasible in a perioperative
      setting but was not specific for postoperative pain intensity and was unable to
      identify analgesia requirements when compared with self-report measures.
FAU - Choo, Eugene K
AU  - Choo EK
AD  - Department of Statistics, University of British Columbia, Vancouver, British
      Columbia, Canada.
FAU - Magruder, William
AU  - Magruder W
FAU - Montgomery, Carolyne J
AU  - Montgomery CJ
FAU - Lim, Joanne
AU  - Lim J
FAU - Brant, Rollin
AU  - Brant R
FAU - Ansermino, J Mark
AU  - Ansermino JM
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - United States
TA  - Anesthesiology
JT  - Anesthesiology
JID - 1300217
SB  - IM
CIN - Anesthesiology. 2011 Feb;114(2):464-5; author reply 465-6. PMID: 21266874
MH  - Adolescent
MH  - Area Under Curve
MH  - Child
MH  - Feasibility Studies
MH  - Female
MH  - *Galvanic Skin Response
MH  - Humans
MH  - Male
MH  - Pain Measurement/methods
MH  - Pain, Postoperative/*diagnosis
MH  - Prospective Studies
MH  - ROC Curve
MH  - Reproducibility of Results
MH  - Self Disclosure
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
EDAT- 2010/06/08 06:00
MHDA- 2010/07/23 06:00
CRDT- 2010/06/08 06:00
PHST- 2010/06/08 06:00 [entrez]
PHST- 2010/06/08 06:00 [pubmed]
PHST- 2010/07/23 06:00 [medline]
AID - 10.1097/ALN.0b013e3181de6ce9 [doi]
PST - ppublish
SO  - Anesthesiology. 2010 Jul;113(1):175-82. doi: 10.1097/ALN.0b013e3181de6ce9.


PMID- 20525843
OWN - NLM
STAT- MEDLINE
DCOM- 20100907
LR  - 20220316
IS  - 1468-2060 (Electronic)
IS  - 0003-4967 (Linking)
VI  - 69
IP  - 9
DP  - 2010 Sep
TI  - EULAR points to consider when establishing, analysing and reporting safety data
      of biologics registers in rheumatology.
PG  - 1596-602
LID - 10.1136/ard.2009.125526 [doi]
AB  - OBJECTIVES: The introduction of biological therapies for the treatment of
      rheumatic diseases has drawn attention to the limitations of traditional means of
      assessing drug safety. Consequently, a series of European academic biologics
      registers dedicated to this task have been established. Increasing reliance upon 
      safety data generated from observational drug registers makes it important to
      convert the lessons learned from such registers into recommendations for
      rheumatologists embarking upon the establishment of future registers, or
      analysing and reporting from new and existing registers. METHODS: The Task Force 
      encompassed 11 scientists from European Rheumatology drug registers. Through an
      informal inventory of critical elements in the establishment of existing
      rheumatoid arthritis drug registers, of analytical strategies used and of
      limitations of their results, several 'points to consider'--beyond established
      generic guidelines for observational registers/studies but with particular
      relevance to biologics registers on safety in rheumatology--were assembled. For
      each 'point to consider', contextual and methodological background and examples
      were compiled. RESULTS: A set of seven points to consider was assembled for the
      establishment of new drug registers with a focus on purpose, population to be
      targeted, data collection, handling and storage as well as ethical and legal
      considerations. For analysis and reporting, nine points to consider were
      assembled (setting, participant, variable, statistical method, descriptive data, 
      outcome data, main results, other analyses and limitations). CONCLUSIONS:
      Thoughtful design and planning before the establishment of biologics registers
      will increase their sustainability, versatility and raw data quality.
      Harmonisation of analyses and reporting from such registers will improve
      interpretation of drug safety studies.
FAU - Dixon, William G
AU  - Dixon WG
AD  - Arthritis Research UK Epidemiology Unit, The University of Manchester, Oxford
      Road, Manchester, UK. will.dixon@manchester.ac.uk
FAU - Carmona, Loreto
AU  - Carmona L
FAU - Finckh, Axel
AU  - Finckh A
FAU - Hetland, Merete Lund
AU  - Hetland ML
FAU - Kvien, Tore K
AU  - Kvien TK
FAU - Landewe, Robert
AU  - Landewe R
FAU - Listing, Joachim
AU  - Listing J
FAU - Nicola, Paulo J
AU  - Nicola PJ
FAU - Tarp, Ulrik
AU  - Tarp U
FAU - Zink, Angela
AU  - Zink A
FAU - Askling, Johan
AU  - Askling J
LA  - eng
PT  - Journal Article
DEP - 20100604
PL  - England
TA  - Ann Rheum Dis
JT  - Annals of the rheumatic diseases
JID - 0372355
RN  - 0 (Antirheumatic Agents)
RN  - 0 (Biological Products)
SB  - IM
CIN - Ann Rheum Dis. 2014 Mar;73(3):628. PMID: 24058015
MH  - Adverse Drug Reaction Reporting Systems/*organization & administration
MH  - Antirheumatic Agents/*adverse effects/therapeutic use
MH  - Biological Products/*adverse effects/therapeutic use
MH  - Epidemiologic Methods
MH  - Europe
MH  - Humans
MH  - Patient Selection
MH  - Registries/*standards
MH  - Rheumatic Diseases/*drug therapy
MH  - Treatment Outcome
EDAT- 2010/06/08 06:00
MHDA- 2010/09/09 06:00
CRDT- 2010/06/08 06:00
PHST- 2010/06/08 06:00 [entrez]
PHST- 2010/06/08 06:00 [pubmed]
PHST- 2010/09/09 06:00 [medline]
AID - ard.2009.125526 [pii]
AID - 10.1136/ard.2009.125526 [doi]
PST - ppublish
SO  - Ann Rheum Dis. 2010 Sep;69(9):1596-602. doi: 10.1136/ard.2009.125526. Epub 2010
      Jun 4.


PMID- 20525445
OWN - NLM
STAT- MEDLINE
DCOM- 20100923
LR  - 20220311
IS  - 0392-856X (Print)
IS  - 0392-856X (Linking)
VI  - 28
IP  - 3
DP  - 2010 May-Jun
TI  - Sonoelastography in the evaluation of painful Achilles tendon in amateur
      athletes.
PG  - 373-8
AB  - OBJECTIVES: The purpose of our paper was to evaluate by sonoelastography the
      Achilles tendon of asymptomatic volunteers and of patients referring for chronic 
      overuse-associated pain, also comparing these findings with those obtained with
      B-mode ultrasound (US). METHODS: This study had local Ethics Committee approval; 
      all patients gave their written informed consent. Twelve patients (9 men, 3
      women, median age 52.5 years, range 38-64 years) referred for unilateral Achilles
      tendon pain associated with amateur sporting activities and 18 healthy controls
      (11 men, 7 women, median age 54 years, range 27-64 years) were studied.
      US/sonoelastography were performed with a Logos EUB8500 system (Hitachi Ltd.,
      Tokyo, Japan) equipped with a 10-6 MHz high-resolution broadband linear array, on
      12 symptomatic tendons and 36 controls. The probe was positioned at the calcaneal
      enthesis, retrocalcaneal bursa, myotendineus juction, and in three different
      areas of the tendon body. The elastogram colour range was translated to a numeric
      score and the differences of tendon resilience were compared by the
      Kruskall-Wallis test. RESULTS: On US, symptomatic tendons showed increased tendon
      thickness (12/12 tendons vs. 8/36 controls, p<0.0001), interruption (5/12 vs.
      0/36, p=0.0004), and fragmentation (5/12 vs. 0/36, p=0.0004). Disappearance of
      fibrillar echotexture was comparable in the two groups. Symptomatic tendons were 
      harder, showing a prevalence of blue to green colour (p<0.0001). Loss of
      elasticity was associated with both fragmentation (p=0.0089) and loss of
      fibrillar texture (p=0.0019), and was inversely correlated with tendon thickness 
      (p<0.0001). Sonoelastography showed no difference between symptomatic and control
      tendons at the enthesis and myotendineus junction. CONCLUSIONS: Sonoelastography 
      shows increased stiffness in symptomatic enlarged Achilles tendons in comparison 
      to normal ones.
FAU - Sconfienza, Luca M
AU  - Sconfienza LM
AD  - Unita di Radiologia, IRCCS Policlinico San Donato, San Donato Milanese, Italy.
FAU - Silvestri, Enzo
AU  - Silvestri E
FAU - Cimmino, Marco A
AU  - Cimmino MA
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
DEP - 20100623
PL  - Italy
TA  - Clin Exp Rheumatol
JT  - Clinical and experimental rheumatology
JID - 8308521
SB  - IM
MH  - Achilles Tendon/*diagnostic imaging
MH  - Adult
MH  - Athletic Injuries/*diagnostic imaging
MH  - Cumulative Trauma Disorders/diagnostic imaging
MH  - Elasticity
MH  - Elasticity Imaging Techniques/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pain/*diagnostic imaging
MH  - Predictive Value of Tests
MH  - Tendon Injuries/*diagnostic imaging
EDAT- 2010/06/08 06:00
MHDA- 2010/09/24 06:00
CRDT- 2010/06/08 06:00
PHST- 2009/09/02 00:00 [received]
PHST- 2010/01/19 00:00 [accepted]
PHST- 2010/06/08 06:00 [entrez]
PHST- 2010/06/08 06:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
AID - 639 [pii]
PST - ppublish
SO  - Clin Exp Rheumatol. 2010 May-Jun;28(3):373-8. Epub 2010 Jun 23.


PMID- 20525200
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1746-1340 (Electronic)
IS  - 1746-1340 (Linking)
VI  - 18
DP  - 2010 Jun 2
TI  - Chiropractic approach to the management of children.
PG  - 16
LID - 10.1186/1746-1340-18-16 [doi]
AB  - BACKGROUND: Chiropractic (Greek: done by hand) is a health care profession
      concerned with the diagnosis, treatment and prevention of disorders of the
      neuromusculoskeletal system and the effects of these disorders on general health.
      There is an emphasis on manual techniques, including joint adjustment and/or
      manipulation, with a particular focus on joint subluxation (World Health
      Organization 2005) or mechanical lesion and restoring function. The
      chiropractor's role in wellness care, prevention and treatment of injury or
      illness is based on education in anatomy and physiology, nutrition, exercise and 
      healthy lifestyle counseling as well as referral to other health practitioners.
      Depending on education, geographic location, scope of practice, as well as
      consumer preference, chiropractors may assume the role of primary care for
      families who are pursuing a more natural and holistic approach to health care for
      their families. OBJECTIVE: To present a perspective on current management of the 
      paediatric patient by members of the chiropractic profession and to make
      recommendations as to how the profession can safely and effectively manage the
      paediatric patient. DISCUSSION: The chiropractic profession holds the
      responsibility of ethical and safe practice and requires the cultivation and
      mastery of both an academic foundation and clinical expertise that distinguishes 
      chiropractic from other disciplines.Research into the effectiveness of
      chiropractic care for paediatric patients has lagged behind that of adult care,
      but this is being addressed through educational programs where research is now
      being incorporated into academic tracks to attain advanced chiropractic degrees. 
      CONCLUSION: Studies in the United States show that over the last several decades,
      chiropractors are the most common complementary and alternative medicine
      providers visited by children and adolescents. Chiropractors continue to seek
      integration with other healthcare providers to provide the most appropriate care 
      for their paediatric patients.In the interest of what is best for the paediatric 
      population in the future, collaborative efforts for research into the
      effectiveness and safety of chiropractic care as an alternative healthcare
      approach for children should be negotiated and are welcomed.
FAU - Vallone, Sharon A
AU  - Vallone SA
AD  - Private Practice, Connecticut, USA.
AD  - Kentuckiana Children's Center, Louisville, KY, USA.
AD  - Post Graduate Faculty, International College of Chiropractic Pediatrics,
      Arlington, VA 22201, USA.
FAU - Miller, Joyce
AU  - Miller J
AD  - Lead Tutor MSc Advanced Practice Paediatrics, Bournemouth University, UK.
FAU - Larsdotter, Annica
AU  - Larsdotter A
AD  - Private Practice, Sydney, Australia.
FAU - Barham-Floreani, Jennifer
AU  - Barham-Floreani J
AD  - Private Practice, Melbourne, Victoria, Australia.
LA  - eng
PT  - Editorial
DEP - 20100602
PL  - England
TA  - Chiropr Osteopat
JT  - Chiropractic & osteopathy
JID - 101245797
PMC - PMC2887887
EDAT- 2010/06/08 06:00
MHDA- 2010/06/08 06:01
CRDT- 2010/06/08 06:00
PHST- 2009/12/19 00:00 [received]
PHST- 2010/06/02 00:00 [accepted]
PHST- 2010/06/08 06:00 [entrez]
PHST- 2010/06/08 06:00 [pubmed]
PHST- 2010/06/08 06:01 [medline]
AID - 1746-1340-18-16 [pii]
AID - 10.1186/1746-1340-18-16 [doi]
PST - epublish
SO  - Chiropr Osteopat. 2010 Jun 2;18:16. doi: 10.1186/1746-1340-18-16.


PMID- 20525193
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1746-1340 (Electronic)
IS  - 1746-1340 (Linking)
VI  - 18
DP  - 2010 Jun 2
TI  - Chiropractic and children: Is more research enough?
PG  - 11
LID - 10.1186/1746-1340-18-11 [doi]
AB  - Many health science research and review articles end with the words: "More
      research is needed". However, when it comes to research, it is not as much a
      question of quantity as of quality. There are a number of important prerequisites
      before research should be initiated. The three pillars, relevance, quality and
      ethics should be respected but for a project to be meaningful, it must also be
      based on plausible rationale.In evidence-based (informed) practice, one takes
      into account not only research-based evidence but also clinical expertise and the
      patients' perspectives. In this paper, we briefly discuss how this should be
      handled in clinical practice is briefly discussed, using the concept of "traffic 
      lights" (red, yellow, green). We explain how the combination of evidence and
      plausibility can be used to reach a decision as to whether a treatment or
      diagnostic procedure is suitable, possible, or unsuitable.In this thematic series
      of Chiropractic & Osteopathy a number of reviews are presented, in which the
      research status of pediatric chiropractic is scrutinized and found wanting. Two
      important aspects were studied in these reviews: the effect of treatment and
      safety issues. Two types of problems were identified: the lack of research in
      general and the lack of research using the appropriate study designs and
      methodology in particular. Therefore, we discuss the meager research noted in the
      areas of chiropractic care in children and the clinical consequences this should 
      have. The prerequisites for "more research" are scrutinized and an example given 
      of suitable research programs.Finally, the important issue of implementation of
      research findings is covered, emphasizing the responsibility of all stakeholders 
      involved at both the undergraduate and the postgraduate level, within
      professional associations, and on an individual level.
FAU - Leboeuf-Yde, Charlotte
AU  - Leboeuf-Yde C
AD  - Nordic Institute of Chiropractic and Clinical Biomechanics, Forskerparken 10,
      DK-5230 Odense M, Denmark. l.hestbaek@nikkb.dk.
FAU - Hestbaek, Lise
AU  - Hestbaek L
LA  - eng
PT  - Editorial
DEP - 20100602
PL  - England
TA  - Chiropr Osteopat
JT  - Chiropractic & osteopathy
JID - 101245797
PMC - PMC2887886
EDAT- 2010/06/08 06:00
MHDA- 2010/06/08 06:01
CRDT- 2010/06/08 06:00
PHST- 2010/04/10 00:00 [received]
PHST- 2010/06/02 00:00 [accepted]
PHST- 2010/06/08 06:00 [entrez]
PHST- 2010/06/08 06:00 [pubmed]
PHST- 2010/06/08 06:01 [medline]
AID - 1746-1340-18-11 [pii]
AID - 10.1186/1746-1340-18-11 [doi]
PST - epublish
SO  - Chiropr Osteopat. 2010 Jun 2;18:11. doi: 10.1186/1746-1340-18-11.


PMID- 20525163
OWN - NLM
STAT- MEDLINE
DCOM- 20101108
LR  - 20211020
IS  - 1472-6963 (Electronic)
IS  - 1472-6963 (Linking)
VI  - 10
DP  - 2010 Jun 2
TI  - General practitioner workforce planning: assessment of four policy directions.
PG  - 148
LID - 10.1186/1472-6963-10-148 [doi]
AB  - BACKGROUND: Estimating the supply of GPs into the future is important in
      forecasting shortages. The lengthy training process for medicine means that
      adjusting supply to meet demand in a timely fashion is problematic. This study
      uses Ireland as a case study to determine the future demand and supply of GPs and
      to assess the potential impact of several possible interventions to address
      future shortages. METHODS: Demand was estimated by applying GP visit rates by age
      and sex to national population projections. Supply was modelled using a range of 
      parameters derived from two national surveys of GPs. A stochastic modelling
      approach was adopted to determine the probable future supply of GPs. Four policy 
      interventions were tested: increasing vocational training places; recruiting GPs 
      from abroad; incentivising later retirement; increasing nurse substitution to
      enable practice nurses to deliver more services. RESULTS: Relative to most other 
      European countries, Ireland has few GPs per capita. Ireland has an ageing
      population and demand is estimated to increase by 19% by 2021. Without
      intervention, the supply of GPs will be 5.7% less than required in 2021.
      Increasing training places will enable supply to meet demand but only after 2019.
      Recruiting GPs from overseas will enable supply to meet demand continuously if
      the number recruited is approximately 0.8 per cent of the current workforce per
      annum. Later retirement has only a short-term impact. Nurse substitution can
      enable supply to meet demand but only if large numbers of practice nurses are
      recruited and allowed to deliver a wide range of GP services. CONCLUSIONS: A
      significant shortfall in GP supply is predicted for Ireland unless recruitment is
      increased. The shortfall will have numerous knock-on effects including price
      increases, longer waiting lists and an increased burden on hospitals. Increasing 
      training places will not provide an adequate response to future shortages.
      Foreign recruitment has ethical considerations but may provide a rapid and
      effective response. Increased nurse substitution appears to offer the best
      long-term prospects of addressing GP shortages and presents the opportunity to
      reshape general practice to meet the demands of the future.
FAU - Teljeur, Conor
AU  - Teljeur C
AD  - Department of Public Health and Primary Care, Trinity College Centre for Health
      Sciences, AMiNCH, Tallaght, Dublin, Ireland. teljeurc@tcd.ie
FAU - Thomas, Stephen
AU  - Thomas S
FAU - O'Kelly, Fergus D
AU  - O'Kelly FD
FAU - O'Dowd, Tom
AU  - O'Dowd T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100602
PL  - England
TA  - BMC Health Serv Res
JT  - BMC health services research
JID - 101088677
SB  - IM
MH  - Aged
MH  - Female
MH  - Forecasting
MH  - Health Care Surveys
MH  - Health Services Needs and Demand/trends
MH  - Humans
MH  - Ireland
MH  - Male
MH  - Middle Aged
MH  - Models, Theoretical
MH  - Physicians, Family/*supply & distribution
MH  - Planning Techniques
MH  - *Policy Making
MH  - Stochastic Processes
PMC - PMC2901341
EDAT- 2010/06/08 06:00
MHDA- 2010/11/09 06:00
CRDT- 2010/06/08 06:00
PHST- 2009/10/23 00:00 [received]
PHST- 2010/06/02 00:00 [accepted]
PHST- 2010/06/08 06:00 [entrez]
PHST- 2010/06/08 06:00 [pubmed]
PHST- 2010/11/09 06:00 [medline]
AID - 1472-6963-10-148 [pii]
AID - 10.1186/1472-6963-10-148 [doi]
PST - epublish
SO  - BMC Health Serv Res. 2010 Jun 2;10:148. doi: 10.1186/1472-6963-10-148.


PMID- 20525013
OWN - NLM
STAT- MEDLINE
DCOM- 20110217
LR  - 20220321
IS  - 1467-9566 (Electronic)
IS  - 0141-9889 (Linking)
VI  - 32
IP  - 6
DP  - 2010 Sep
TI  - 'Every space is claimed': smokers' experiences of tobacco denormalisation.
PG  - 914-29
LID - 10.1111/j.1467-9566.2010.01251.x [doi]
AB  - Over the past decade, the strategy of 'denormalising' tobacco use has become one 
      of the cornerstones of the global tobacco control movement. Although tobacco
      denormalisation policies primarily affect people on the lowest rungs of the
      social ladder, few qualitative studies have explicitly set out to explore how
      smokers have experienced and responded to these legislative and social changes in
      attitudes towards tobacco use. Drawing on a qualitative study of interviews with 
      25 current and ex-smokers living in Vancouver, Canada, this paper examines the
      ways they interpret and respond to the new socio-political environment in which
      they must manage the increasingly problematised practice of tobacco smoking.
      Overall, while not opposed to smoking restrictions per se, study participants
      felt that recent legislation, particularly efforts to prohibit smoking in a
      variety of outdoor settings, was overly restrictive and that all public space had
      increasingly been 'claimed' by non-smokers. Also apparent from participants'
      accounts was the high degree of stigma attached to smoking. However, although the
      'denormalisation' environment had encouraged several participants to quit
      smoking, the majority continued to smoke, raising ethical and practical questions
      about the value of denormalisation strategies as a way of reducing
      smoking-related mortality and morbidity.
CI  - (c) 2010 The Authors. Journal compilation (c) 2010 Foundation for the Sociology
      of Health & Illness/Blackwell Publishing Ltd.
FAU - Bell, Kirsten
AU  - Bell K
AD  - Department of Anthropology, University of British Columbia, Canada.
      kibell@interchange.ubc.ca
FAU - McCullough, Lucy
AU  - McCullough L
FAU - Salmon, Amy
AU  - Salmon A
FAU - Bell, Jennifer
AU  - Bell J
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100526
PL  - England
TA  - Sociol Health Illn
JT  - Sociology of health & illness
JID - 8205036
SB  - IM
MH  - Adult
MH  - Aged
MH  - British Columbia
MH  - Female
MH  - Health Policy
MH  - Health Surveys
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Politics
MH  - *Prejudice
MH  - Qualitative Research
MH  - Risk Factors
MH  - Risk-Taking
MH  - Smoking/epidemiology/*psychology
MH  - Smoking Cessation/*psychology
MH  - Smoking Prevention
MH  - Social Marketing
MH  - *Social Perception
MH  - Socioeconomic Factors
MH  - *Tobacco
MH  - Young Adult
EDAT- 2010/06/08 06:00
MHDA- 2011/02/18 06:00
CRDT- 2010/06/08 06:00
PHST- 2010/06/08 06:00 [entrez]
PHST- 2010/06/08 06:00 [pubmed]
PHST- 2011/02/18 06:00 [medline]
AID - SHIL1251 [pii]
AID - 10.1111/j.1467-9566.2010.01251.x [doi]
PST - ppublish
SO  - Sociol Health Illn. 2010 Sep;32(6):914-29. doi: 10.1111/j.1467-9566.2010.01251.x.
      Epub 2010 May 26.


PMID- 20524827
OWN - NLM
STAT- MEDLINE
DCOM- 20110103
LR  - 20101202
IS  - 1933-0693 (Electronic)
IS  - 0022-3085 (Linking)
VI  - 113
IP  - 6
DP  - 2010 Dec
TI  - Neurosurgeons' perspectives on psychosurgery and neuroenhancement: a qualitative 
      study at one center.
PG  - 1212-8
LID - 10.3171/2010.5.JNS091896 [doi]
AB  - OBJECT: Advances in the neurosciences are stirring debate regarding the ethical
      issues surrounding novel neurosurgical interventions. The application of deep
      brain stimulation (DBS) for treating refractory psychiatric disease, for
      instance, has introduced the prospect of altering disorders of mind and behavior 
      and the potential for neuroenhancement. The attitudes of current and future
      providers of this technology and their position regarding its possible future
      applications are unknown. The authors sought to gauge the opinions of
      neurosurgical staff and trainees toward various uses of neuromodulation
      technology including psychosurgery and neuroenhancement. METHODS: The authors
      conducted a qualitative study involving in-depth interviews with 47 neurosurgery 
      staff, trainees, and other neuroclinicians at a quaternary care center. RESULTS: 
      Several general themes emerged from the interviews. These included universal
      support for psychosurgery given adequate informed consent and rigorous scientific
      methodology, as well as a relative consensus regarding the priority given to
      patient autonomy and the preservation of personal identity. Participants'
      attitudes toward the future use of DBS and other means of neuromodulation for
      cognitive enhancement and personality alteration revealed less agreement,
      although most participants felt that alteration of nonpathological traits is
      objectionable. CONCLUSIONS: There is support in the neurosurgical community for
      the surgical management of refractory psychiatric disease. The use of
      neuromodulation for the alteration of nonpathological traits is morally and
      ethically dubious when it is out of sync with the values of society at large.
      Both DBS and neuromodulation will have far-reaching and profound public health
      implications.
FAU - Mendelsohn, Daniel
AU  - Mendelsohn D
AD  - Division of Neurosurgery, Toronto Western Hospital, University of Toronto,
      Ontario, Canada.
FAU - Lipsman, Nir
AU  - Lipsman N
FAU - Bernstein, Mark
AU  - Bernstein M
LA  - eng
GR  - 80045/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100604
PL  - United States
TA  - J Neurosurg
JT  - Journal of neurosurgery
JID - 0253357
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Attitude of Health Personnel
MH  - Deep Brain Stimulation/*ethics
MH  - Female
MH  - Humans
MH  - Informed Consent
MH  - Interviews as Topic
MH  - Male
MH  - Middle Aged
MH  - Neurosurgery/*ethics
MH  - Neurosurgical Procedures/*ethics
MH  - Psychosurgery/*ethics
MH  - Young Adult
EDAT- 2010/06/08 06:00
MHDA- 2011/01/05 06:00
CRDT- 2010/06/08 06:00
PHST- 2010/06/08 06:00 [entrez]
PHST- 2010/06/08 06:00 [pubmed]
PHST- 2011/01/05 06:00 [medline]
AID - 10.3171/2010.5.JNS091896 [doi]
PST - ppublish
SO  - J Neurosurg. 2010 Dec;113(6):1212-8. doi: 10.3171/2010.5.JNS091896. Epub 2010 Jun
      4.


PMID- 20524076
OWN - NLM
STAT- MEDLINE
DCOM- 20120330
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 17
IP  - 3
DP  - 2011 Sep
TI  - Teaching ethics to engineers: ethical decision making parallels the engineering
      design process.
PG  - 597-605
LID - 10.1007/s11948-010-9213-7 [doi]
AB  - In order to fulfill ABET requirements, Northern Arizona University's Civil and
      Environmental engineering programs incorporate professional ethics in several of 
      its engineering courses. This paper discusses an ethics module in a 3rd year
      engineering design course that focuses on the design process and technical
      writing. Engineering students early in their student careers generally possess
      good black/white critical thinking skills on technical issues. Engineering design
      is the first time students are exposed to "grey" or multiple possible solution
      technical problems. To identify and solve these problems, the engineering design 
      process is used. Ethical problems are also "grey" problems and present similar
      challenges to students. Students need a practical tool for solving these ethical 
      problems. The step-wise engineering design process was used as a model to
      demonstrate a similar process for ethical situations. The ethical decision making
      process of Martin and Schinzinger was adapted for parallelism to the design
      process and presented to students as a step-wise technique for identification of 
      the pertinent ethical issues, relevant moral theories, possible outcomes and a
      final decision. Students had greatest difficulty identifying the broader, global 
      issues presented in an ethical situation, but by the end of the module, were
      better able to not only identify the broader issues, but also to more
      comprehensively assess specific issues, generate solutions and a desired response
      to the issue.
FAU - Bero, Bridget
AU  - Bero B
AD  - Department of Civil and Environmental Engineering, Northern Arizona University,
      Box 15600, Flagstaff, AZ 86011, USA. Bridget.bero@nau.edu
FAU - Kuhlman, Alana
AU  - Kuhlman A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100604
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Arizona
MH  - *Curriculum
MH  - Decision Making/*ethics
MH  - Engineering/education/*ethics/methods
MH  - Ethics, Professional/*education
MH  - Humans
MH  - Problem Solving/*ethics
MH  - Teaching/*methods
MH  - Universities
MH  - Writing/standards
EDAT- 2010/06/05 06:00
MHDA- 2012/03/31 06:00
CRDT- 2010/06/05 06:00
PHST- 2010/01/14 00:00 [received]
PHST- 2010/05/18 00:00 [accepted]
PHST- 2010/06/05 06:00 [entrez]
PHST- 2010/06/05 06:00 [pubmed]
PHST- 2012/03/31 06:00 [medline]
AID - 10.1007/s11948-010-9213-7 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2011 Sep;17(3):597-605. doi: 10.1007/s11948-010-9213-7. Epub 2010
      Jun 4.


PMID- 20523212
OWN - NLM
STAT- MEDLINE
DCOM- 20101220
LR  - 20181201
IS  - 1365-2346 (Electronic)
IS  - 0265-0215 (Linking)
VI  - 27
IP  - 10
DP  - 2010 Oct
TI  - Xenon anaesthesia produces better early postoperative cognitive recovery than
      sevoflurane anaesthesia.
PG  - 912-6
LID - 10.1097/EJA.0b013e32833b652d [doi]
AB  - BACKGROUND AND OBJECTIVE: Xenon anaesthesia may have the potential to reduce
      postoperative cognitive impairment after general anaesthesia. This randomized
      double-blind controlled trial was designed to compare the early postoperative
      cognitive recovery after xenon and sevoflurane anaesthesia. METHODS: After
      institutional ethics approval, we obtained informed written consent from 60
      adults, with American Society of Anesthesiologists I or II status, scheduled for 
      elective surgery with an estimated surgery time between 60 and 360 min. Patients 
      were randomized to receive xenon or sevoflurane anaesthesia. Both groups received
      a remifentanil infusion adjusted to clinical needs based on patients'
      haemodynamic and state entropy of less than 60. In cases of state entropy of at
      least 60 during the first 15 min after induction, patients in the xenon group
      received a propofol infusion targeted to state entropy of less than 60. The
      primary end-point of the study was the early postoperative cognitive recovery
      evaluated by the Short Orientation Memory Concentration Test. RESULTS: There was 
      no significant difference in the mean preoperative Short Orientation Memory
      Concentration Test values between groups (sevoflurane 2.7 +/- 3.2 and xenon 3.2
      +/- 2.6; P, 0.53). Awakening was significantly faster in the xenon group
      (sevoflurane 8 +/- 4 min and xenon 3 +/- 1 min; P < 0.001). Patients receiving
      xenon presented significantly lower Short Orientation Memory Concentration Test
      scores at 30 min (sevoflurane 6.7 +/- 5.9 and xenon 3.3 +/- 3.1; P 0.003) and 60 
      min (xenon 2.1 +/- 3 and sevoflurane 5 +/- 4.1; P 0.003) after extubation.
      CONCLUSION: Xenon anaesthesia was associated with faster emergence and with
      better early postoperative cognitive recovery than sevoflurane anaesthesia.
FAU - Bronco, Alfio
AU  - Bronco A
AD  - U.O. Anestesia e Rianimazione I, San Gerardo Hospital, Monza, Italy.
FAU - Ingelmo, Pablo M
AU  - Ingelmo PM
FAU - Aprigliano, Michele
AU  - Aprigliano M
FAU - Turella, Marta
AU  - Turella M
FAU - Sahillioglu, Emre
AU  - Sahillioglu E
FAU - Bucciero, Mario
AU  - Bucciero M
FAU - Somaini, Marta
AU  - Somaini M
FAU - Fumagalli, Roberto
AU  - Fumagalli R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - Eur J Anaesthesiol
JT  - European journal of anaesthesiology
JID - 8411711
RN  - 0 (Anesthetics, Inhalation)
RN  - 0 (Methyl Ethers)
RN  - 0 (Piperidines)
RN  - 38LVP0K73A (Sevoflurane)
RN  - 3H3U766W84 (Xenon)
RN  - P10582JYYK (Remifentanil)
RN  - YI7VU623SF (Propofol)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Anesthesia Recovery Period
MH  - Anesthetics, Inhalation/*pharmacology
MH  - Cognition/drug effects
MH  - Double-Blind Method
MH  - Elective Surgical Procedures/methods
MH  - Entropy
MH  - Female
MH  - Humans
MH  - Male
MH  - Methyl Ethers/*pharmacology
MH  - Middle Aged
MH  - Piperidines/therapeutic use
MH  - Postoperative Period
MH  - Propofol/therapeutic use
MH  - Remifentanil
MH  - Sevoflurane
MH  - Time Factors
MH  - Xenon/*pharmacology
EDAT- 2010/06/05 06:00
MHDA- 2010/12/21 06:00
CRDT- 2010/06/05 06:00
PHST- 2010/06/05 06:00 [entrez]
PHST- 2010/06/05 06:00 [pubmed]
PHST- 2010/12/21 06:00 [medline]
AID - 10.1097/EJA.0b013e32833b652d [doi]
PST - ppublish
SO  - Eur J Anaesthesiol. 2010 Oct;27(10):912-6. doi: 10.1097/EJA.0b013e32833b652d.


PMID- 20522749
OWN - NLM
STAT- MEDLINE
DCOM- 20100616
LR  - 20100604
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Linking)
VI  - 328
IP  - 5983
DP  - 2010 Jun 4
TI  - Ethics. Researchers to return blood samples to the Yanomamo.
PG  - 1218
LID - 10.1126/science.328.5983.1218 [doi]
FAU - Couzin-Frankel, Jennifer
AU  - Couzin-Frankel J
LA  - eng
PT  - News
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
SB  - IM
MH  - *Blood
MH  - Blood Preservation
MH  - Blood Specimen Collection/*ethics
MH  - Brazil
MH  - Cryopreservation
MH  - *Ethics, Research
MH  - Humans
MH  - *Indians, South American
MH  - Venezuela
EDAT- 2010/06/05 06:00
MHDA- 2010/06/17 06:00
CRDT- 2010/06/05 06:00
PHST- 2010/06/05 06:00 [entrez]
PHST- 2010/06/05 06:00 [pubmed]
PHST- 2010/06/17 06:00 [medline]
AID - 328/5983/1218 [pii]
AID - 10.1126/science.328.5983.1218 [doi]
PST - ppublish
SO  - Science. 2010 Jun 4;328(5983):1218. doi: 10.1126/science.328.5983.1218.


PMID- 20522110
OWN - NLM
STAT- MEDLINE
DCOM- 20100907
LR  - 20100604
IS  - 1600-0579 (Electronic)
IS  - 1396-5883 (Linking)
VI  - 14
IP  - 2
DP  - 2010 May
TI  - Comparison of dental education and professional development between mainland
      China and North America.
PG  - 106-12
LID - 10.1111/j.1600-0579.2009.00599.x [doi]
AB  - Different educational and professional developments within the dental field
      create different sets of missions, norms, and practices regarding dental diseases
      and their appropriate treatment. This review has addressed differences in dental 
      education and professional development between mainland China and North America. 
      Many factors influence the choice of model and it is very difficult to predict
      which model will become predominant. However, there is growing sentiment that the
      independent faculty model in North America is logical and superior to the model, 
      which 'integrates' dental and medical education in mainland China. Many North
      America dental schools place a high priority on preclinical and clinical training
      in the curriculum in order to expose students to patient oral health needs and
      systemic dental problems much earlier than in mainland China. North America
      dental schools promote and embrace students self-learning skills by the use of
      PBL, CRL, and TRAD education methodologies and new e-based technologies and
      approaches whereby students learn rather than are taught. In mainland China, the 
      traditional lecture-based format is still employed in the majority of dental
      schools; however, strategies to enhance students self-learning skills is
      increasingly utilised in most well-known Chinese dental schools. The Chinese
      dental education model, which treats dentistry as a sub-specialty of medicine,
      has brought about fundamental differences, with the dentist functioning
      essentially as a stomatologist. For example, China has built up a large oral and 
      maxillofacial surgery society, and craniofacial surgery is performed to a much
      broader extent by Chinese dentists than by most North American counterparts. In
      North America, dentists engage in full-time work, attend continuing
      training/education programmes, belong to an association, gain legal status, and
      construct a code of ethics emphasising the quality of care delivered to the
      public. Currently, continuing dental education in North America is available
      through a variety of venues involving licensing authorities, universities and
      private programmes. The concept of professional development in mainland China is 
      relatively new and is still considered primarily in the context of promotion or
      achieving a higher professional title. Mandatory continuing dental professional
      education requirements do not guarantee the competence of members of the
      profession. Today, the Chinese government and society place increasing emphasis
      upon the accountability of self-regulating professions. Rather than attempting to
      summarise the current scope of dental education and professional development
      between mainland China and North America, this paper hopes to enhance mutual
      understanding, and promote greater academic exchanges in dental education.
FAU - Wu, Z Y
AU  - Wu ZY
AD  - College of Stomatology, Shanghai Jiao Tong University, Shanghai, China.
      wuzhengyi123@126.com
FAU - Zhang, Z Y
AU  - Zhang ZY
FAU - Jiang, X Q
AU  - Jiang XQ
FAU - Guo, L
AU  - Guo L
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur J Dent Educ
JT  - European journal of dental education : official journal of the Association for
      Dental Education in Europe
JID - 9712132
MH  - Canada
MH  - Certification
MH  - China
MH  - Curriculum
MH  - Education, Dental/economics/*methods
MH  - Educational Measurement
MH  - Humans
MH  - Licensure
MH  - *Models, Educational
MH  - Professional Practice/*organization & administration
MH  - School Admission Criteria
MH  - Schools, Dental/economics/*organization & administration
MH  - Specialties, Dental/education
MH  - United States
EDAT- 2010/06/05 06:00
MHDA- 2010/09/08 06:00
CRDT- 2010/06/05 06:00
PHST- 2010/06/05 06:00 [entrez]
PHST- 2010/06/05 06:00 [pubmed]
PHST- 2010/09/08 06:00 [medline]
AID - EJE599 [pii]
AID - 10.1111/j.1600-0579.2009.00599.x [doi]
PST - ppublish
SO  - Eur J Dent Educ. 2010 May;14(2):106-12. doi: 10.1111/j.1600-0579.2009.00599.x.


PMID- 20522075
OWN - NLM
STAT- MEDLINE
DCOM- 20100915
LR  - 20101109
IS  - 1479-828X (Electronic)
IS  - 0004-8666 (Linking)
VI  - 50
IP  - 2
DP  - 2010 Apr
TI  - Short-term clinical and quality-of-life outcomes in women treated by the
      TVT-Secur procedure.
PG  - 168-72
LID - 10.1111/j.1479-828X.2010.01139.x [doi]
AB  - BACKGROUND: The TVT-Secur (Ethicon, Somerville, NJ, USA) is a minimally invasive 
      suburethral synthetic sling used in the treatment of female stress urinary
      incontinence. It claims to cause less postoperative pain and to enable performing
      in an office setting. However, this may be at the expense of a significant
      learning curve and a higher early failure rate. AIMS: To assess objectively the
      success rate of the TVT-Secur procedure in the 'U' configuration at six months.
      Secondary outcomes focussed on subjective success rates, complications, patient
      satisfaction and quality-of-life (QOL). METHODS: A prospective observational
      study was undertaken at two tertiary referral urogynaecology centres. A cohort of
      42 consecutive patients with urodynamic stress incontinence who underwent the
      TVT-Secur procedure in the 'U' configuration between November 2006 and August
      2007 were followed up for six months. Three standardised QOL questionnaires were 
      completed preoperatively and at six months. A urogenital history, visual analogue
      score (VAS) for patient satisfaction, uroflow and urinary stress test were
      performed at six months. RESULTS: Recruitment was ceased prematurely because of a
      high number of early failures. Objective and subjective success rates at six
      months were 58.3% and 51.3% respectively. Complications included urinary tract
      infections, voiding difficulty, groin discomfort, haematoma, vaginal pain, tape
      erosion and intra-operative dislodgement of tape. Prevalence of de novo urge
      incontinence was 10.3%. Only symptom-specific QOL scores improved and only 48.6% 
      indicated a high level satisfaction (VAS > or = 80%) with TVT-Secur. CONCLUSION: 
      On the basis of this limited study, we are hesitant to recommend the 'U'
      configuration of the TVT-Secur over its more established counterparts, the TVT
      and TVT-O.
FAU - Lim, Jeanette L
AU  - Lim JL
AD  - Department of Urogynaecology, Royal Women's Hospital, corner Grattan Street and
      Flemington Road, Parkville, Vic. 3052, Australia. jeanettelim74@hotmail.com
FAU - de Cuyper, Eva M J
AU  - de Cuyper EM
FAU - Cornish, Ann
AU  - Cornish A
FAU - Frazer, Malcolm
AU  - Frazer M
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Aust N Z J Obstet Gynaecol
JT  - The Australian & New Zealand journal of obstetrics & gynaecology
JID - 0001027
SB  - IM
CIN - Aust N Z J Obstet Gynaecol. 2010 Oct;50(5):499. PMID: 21039390
MH  - Aged
MH  - Female
MH  - *Gynecologic Surgical Procedures
MH  - Hematoma/etiology/surgery
MH  - Humans
MH  - Middle Aged
MH  - Postoperative Complications/etiology
MH  - Prospective Studies
MH  - *Quality of Life
MH  - *Suburethral Slings
MH  - Treatment Failure
MH  - Urinary Incontinence, Stress/*surgery
MH  - Urinary Tract Infections/etiology
EDAT- 2010/06/05 06:00
MHDA- 2010/09/16 06:00
CRDT- 2010/06/05 06:00
PHST- 2010/06/05 06:00 [entrez]
PHST- 2010/06/05 06:00 [pubmed]
PHST- 2010/09/16 06:00 [medline]
AID - AJO1139 [pii]
AID - 10.1111/j.1479-828X.2010.01139.x [doi]
PST - ppublish
SO  - Aust N Z J Obstet Gynaecol. 2010 Apr;50(2):168-72. doi:
      10.1111/j.1479-828X.2010.01139.x.


PMID- 20521742
OWN - NLM
STAT- MEDLINE
DCOM- 20100813
LR  - 20100604
IS  - 0024-6921 (Print)
IS  - 0024-6921 (Linking)
VI  - 162
IP  - 2
DP  - 2010 Mar-Apr
TI  - Physician noncompete agreements and the ethical practice of medicine.
PG  - 110-3
FAU - Price, David T
AU  - Price DT
AD  - Urology Associates of the Diagnostic Clinic of Longview, Texas, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J La State Med Soc
JT  - The Journal of the Louisiana State Medical Society : official organ of the
      Louisiana State Medical Society
JID - 7505618
SB  - IM
MH  - Contracts/*ethics/legislation & jurisprudence
MH  - Economic Competition/*ethics/legislation & jurisprudence
MH  - *Ethics, Medical
MH  - Group Practice/*economics/*ethics/legislation & jurisprudence
MH  - Humans
MH  - *Physicians
MH  - Practice Management, Medical/*economics/*ethics/legislation & jurisprudence
MH  - United States
EDAT- 2010/06/05 06:00
MHDA- 2010/08/14 06:00
CRDT- 2010/06/05 06:00
PHST- 2010/06/05 06:00 [entrez]
PHST- 2010/06/05 06:00 [pubmed]
PHST- 2010/08/14 06:00 [medline]
PST - ppublish
SO  - J La State Med Soc. 2010 Mar-Apr;162(2):110-3.


PMID- 20521577
OWN - NLM
STAT- MEDLINE
DCOM- 20100706
LR  - 20180221
IS  - 1750-4589 (Print)
IS  - 1750-4589 (Linking)
VI  - 20
IP  - 5
DP  - 2010 May
TI  - Legal, professional and ethical considerations of advanced perioperative
      practice.
PG  - 177-80
AB  - Advances within the NHS have recognised nurses in roles that go beyond the
      historical parameters of their initial training and role characteristics (DH
      1999, DH 2000). Working within such a role creates added responsibilities of
      advancing practice and the continuing development of knowledge and skills. Nurses
      working at a higher level of practice will require an understanding of not only
      the professional and legal implications that new roles create, but also an
      awareness of the ethical dilemmas that will undoubtedly become increasingly
      complex (Bartter 2002). This article examines the professional, legal and ethical
      implications of advanced perioperative practice through the author's role as a
      surgical care practitioner (SCP).
FAU - Quick, Julie
AU  - Quick J
AD  - Manor Hospital, Walsall, UK. julie.quick@walsallhospitals.nhs.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Perioper Pract
JT  - Journal of perioperative practice
JID - 101271023
MH  - Employment/ethics/legislation & jurisprudence
MH  - Ethics, Nursing
MH  - Humans
MH  - Malpractice
MH  - Nurse's Role
MH  - Perioperative Nursing/*ethics/*legislation & jurisprudence
MH  - Professional Practice/ethics/legislation & jurisprudence
MH  - United Kingdom
EDAT- 2010/06/05 06:00
MHDA- 2010/07/07 06:00
CRDT- 2010/06/05 06:00
PHST- 2010/06/05 06:00 [entrez]
PHST- 2010/06/05 06:00 [pubmed]
PHST- 2010/07/07 06:00 [medline]
AID - 10.1177/175045891002000503 [doi]
PST - ppublish
SO  - J Perioper Pract. 2010 May;20(5):177-80. doi: 10.1177/175045891002000503.


PMID- 20521442
OWN - NLM
STAT- MEDLINE
DCOM- 20100629
LR  - 20191111
IS  - 0065-2423 (Print)
IS  - 0065-2423 (Linking)
VI  - 50
DP  - 2010
TI  - Component-resolved allergy diagnosis by microarray: potential, pitfalls, and
      prospects.
PG  - 87-101
AB  - Diagnosis of IgE-mediated allergies is not always straightforward, as traditional
      tests can yield equivocal or negative results and provocation tests are hampered 
      by several practical and ethical limitations. During the last decades two new in 
      vitro techniques have entered the field of allergy diagnosis, that is,
      flow-assisted analysis of allergen-specific activated basophils and
      component-resolved diagnosis (CRD). This review focuses on component-resolved
      allergy diagnosis by microarray that has evolved from recent advances in
      molecular allergology and biochip technology. The technique allows a
      comprehensive analysis of individual sensitization profiles with multiplexed
      purified and recombinant allergens within a single run using only a minute amount
      of serum, providing information that largely exceeds the output from current sIgE
      capturing tools. Actually, multiplexing allows identification of diagnostic
      patterns that may facilitate the formulation of diagnostic algorithms. Although
      CRD by microarray sounds promising, the diagnostic performance requires further
      intensive assessment before it can enter mainstream application. In our opinion, 
      the technique should currently be considered a complementary diagnostic tool
      rather than a first-line choice.
FAU - De Knop, K J
AU  - De Knop KJ
AD  - Department of Immunology-Allergology-Rheumatology, Faculty of Medicine,
      University of Antwerp, Antwerpen, Belgium.
FAU - Bridts, C H
AU  - Bridts CH
FAU - Verweij, M M
AU  - Verweij MM
FAU - Hagendorens, M M
AU  - Hagendorens MM
FAU - De Clerck, L S
AU  - De Clerck LS
FAU - Stevens, W J
AU  - Stevens WJ
FAU - Ebo, D G
AU  - Ebo DG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Adv Clin Chem
JT  - Advances in clinical chemistry
JID - 2985173R
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens
MH  - Humans
MH  - Hypersensitivity/*diagnosis
MH  - Immunoglobulin E/analysis/*metabolism
MH  - Protein Array Analysis/*methods
MH  - Skin Tests
RF  - 62
EDAT- 2010/06/05 06:00
MHDA- 2010/06/30 06:00
CRDT- 2010/06/05 06:00
PHST- 2010/06/05 06:00 [entrez]
PHST- 2010/06/05 06:00 [pubmed]
PHST- 2010/06/30 06:00 [medline]
AID - 10.1016/s0065-2423(10)50005-2 [doi]
PST - ppublish
SO  - Adv Clin Chem. 2010;50:87-101. doi: 10.1016/s0065-2423(10)50005-2.


PMID- 20521175
OWN - NLM
STAT- MEDLINE
DCOM- 20120330
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 17
IP  - 3
DP  - 2011 Sep
TI  - Should engineering ethics be taught?
PG  - 583-96
LID - 10.1007/s11948-010-9211-9 [doi]
AB  - Should engineering ethics be taught? Despite the obvious truism that we all want 
      our students to be moral engineers who practice virtuous professional behavior, I
      argue, in this article that the question itself obscures several ambiguities that
      prompt preliminary resolution. Upon clarification of these ambiguities, and an
      attempt to delineate key issues that make the question a philosophically
      interesting one, I conclude that engineering ethics not only should not, but
      cannot, be taught if we understand "teaching engineering ethics" to mean training
      engineers to be moral individuals (as some advocates seem to have proposed).
      However, I also conclude that there is a justification to teaching engineering
      ethics, insofar as we are able to clearly identify the most desirable and
      efficacious pedagogical approach to the subject area, which I propose to be a
      case study-based format that utilizes the principle of human cognitive pattern
      recognition.
FAU - Abate, Charles J
AU  - Abate CJ
AD  - Electrical Engineering Technology Department, Onondaga Community College,
      Syracuse, NY 13215, USA. abatec@sunyocc.edu
LA  - eng
PT  - Journal Article
DEP - 20100604
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Engineering/education/*ethics
MH  - Ethics, Professional/*education
MH  - Humans
MH  - Teaching/*methods
EDAT- 2010/06/04 06:00
MHDA- 2012/03/31 06:00
CRDT- 2010/06/04 06:00
PHST- 2009/12/01 00:00 [received]
PHST- 2010/05/18 00:00 [accepted]
PHST- 2010/06/04 06:00 [entrez]
PHST- 2010/06/04 06:00 [pubmed]
PHST- 2012/03/31 06:00 [medline]
AID - 10.1007/s11948-010-9211-9 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2011 Sep;17(3):583-96. doi: 10.1007/s11948-010-9211-9. Epub 2010 
      Jun 4.


PMID- 20521117
OWN - NLM
STAT- MEDLINE
DCOM- 20100621
LR  - 20211020
IS  - 1573-0980 (Electronic)
IS  - 1386-7415 (Linking)
VI  - 31
IP  - 3
DP  - 2010 Jun
TI  - "Just one animal among many?" Existential phenomenology, ethics, and stem cell
      research.
PG  - 197-224
LID - 10.1007/s11017-010-9143-z [doi]
AB  - Stem cell research and associated or derivative biotechnologies are proceeding at
      a pace that has left bioethics behind as a discipline that is more or less
      reactionary to their developments. Further, much of the available ethical
      deliberation remains determined by the conceptual framework of late modern
      metaphysics and the correlative ethical theories of utilitarianism and
      deontology. Lacking, to any meaningful extent, is a sustained engagement with
      ontological and epistemological critiques, such as with "postmodern" thinking
      like that of Heidegger's existential phenomenology. Some basic "Heideggerian"
      conceptual strategies are reviewed here as a way of remedying this deficiency and
      adding to ethical deliberation about current stem cell research practices.
FAU - Swazo, Norman K
AU  - Swazo NK
AD  - College of Science and General Studies, Alfaisal University, P.O. Box 50927,
      Riyadh 11533, Saudi Arabia. nswazo@alfaisal.edu
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Theor Med Bioeth
JT  - Theoretical medicine and bioethics
JID - 9805378
SB  - IM
MH  - Animals
MH  - Biomedical Research/*ethics
MH  - Embryo Research/*ethics
MH  - Ethics, Medical
MH  - *Ethics, Research
MH  - Existentialism
MH  - Humans
MH  - Metaphysics
MH  - *Philosophy, Medical
MH  - Stem Cell Transplantation/*ethics
PMC - PMC2883080
EDAT- 2010/06/04 06:00
MHDA- 2010/06/22 06:00
CRDT- 2010/06/04 06:00
PHST- 2010/06/04 06:00 [entrez]
PHST- 2010/06/04 06:00 [pubmed]
PHST- 2010/06/22 06:00 [medline]
AID - 10.1007/s11017-010-9143-z [doi]
PST - ppublish
SO  - Theor Med Bioeth. 2010 Jun;31(3):197-224. doi: 10.1007/s11017-010-9143-z.


PMID- 20521006
OWN - NLM
STAT- MEDLINE
DCOM- 20100902
LR  - 20190911
IS  - 0034-7167 (Print)
IS  - 0034-7167 (Linking)
VI  - 63
IP  - 2
DP  - 2010 Mar-Apr
TI  - [Legal issues of Brazilian hyperbaric nursing: why regulate?].
PG  - 312-6
LID - S0034-71672010000200022 [pii]
AB  - This study aimed to show the needs to standardize nursing care related to
      hyperbaric oxygenation and regulate working conditions for nursing staff that
      works on this area. They approach the legislation at the Brazilian Society of
      Hyperbaric Medicine, on Brazilian Chapter of the Undersea and Hyperbaric Medical 
      Society, on Regulating Rules of the Ministry of Labor and on the Code of Ethics
      of Nursing Professionals, as instruments still insufficient to legalize the
      Hyperbaric Nurse, its procedures in hyperbaric conditions and pressurized
      environments. It allowed pondering on the disclosure of the state of art of
      hyperbaric nursing, as well as the incorporation of this activity in relation to 
      the specialties on the COFEN Resolution 290/2004 and postgraduate courses in
      Nursing.
FAU - Alcantara, Leila Milman
AU  - Alcantara LM
AD  - Marinha do Brasil, Hospital Naval Marcilio Dias, Escola de Saude, Rio de Janeiro,
      RJ. leilacantara@gmail.com
FAU - Leite, Josete Luzia
AU  - Leite JL
FAU - Trevizan, Maria Auxiliadora
AU  - Trevizan MA
FAU - Mendes, Isabel Amelia Costa
AU  - Mendes IA
FAU - Uggeri, Cathi Julian Ribeiro
AU  - Uggeri CJ
FAU - Stipp, Marluci Andrade Conceicao
AU  - Stipp MA
FAU - Lacerda, Elias Pereira de
AU  - Lacerda EP
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Aspectos legais da enfermagem hiperbarica brasileira: por que regulamentar?
PL  - Brazil
TA  - Rev Bras Enferm
JT  - Revista brasileira de enfermagem
JID - 7910105
MH  - Brazil
MH  - Hyperbaric Oxygenation/*nursing
MH  - *Legislation, Nursing
EDAT- 2010/06/04 06:00
MHDA- 2010/09/03 06:00
CRDT- 2010/06/04 06:00
PHST- 2008/09/17 00:00 [received]
PHST- 2010/01/06 00:00 [accepted]
PHST- 2010/06/04 06:00 [entrez]
PHST- 2010/06/04 06:00 [pubmed]
PHST- 2010/09/03 06:00 [medline]
AID - S0034-71672010000200022 [pii]
AID - 10.1590/s0034-71672010000200022 [doi]
PST - ppublish
SO  - Rev Bras Enferm. 2010 Mar-Apr;63(2):312-6. doi: 10.1590/s0034-71672010000200022.


PMID- 20521004
OWN - NLM
STAT- MEDLINE
DCOM- 20100902
LR  - 20190911
IS  - 0034-7167 (Print)
IS  - 0034-7167 (Linking)
VI  - 63
IP  - 2
DP  - 2010 Mar-Apr
TI  - [The interview in qualitative research of pediatric nursing].
PG  - 300-6
LID - S0034-71672010000200020 [pii]
AB  - This systematic review aimed to explore the contributions of Brazilian nursing
      literature about the use of interviews as a data collection technique in research
      with children. Articles were searched in the Virtual Health Library, using Health
      Terminology, between 1998 and 2008. Thirteen articles were selected, whose
      analysis allowed for reflections on the type of study, investigated age range,
      ethical considerations, data collection techniques, among others. Data indicated 
      that nurses have used interviews isolated or associated with other techniques.
      Studies need to present the data collection phase in further detail, so as to
      indicate ways to improve the interview technique with children in nursing
      research.
FAU - Oliveira, Rosana Beatriz Goncalves de
AU  - Oliveira RB
AD  - Universidade de Sao Paulo, Escola de Enfermagem de Ribeirao Preto, Ribeirao
      Preto, SP. lb.toso@certto.com.br
FAU - Sparapani, Valeria de Cassia
AU  - Sparapani Vde C
FAU - Scochi, Carmen Gracinda Silvan
AU  - Scochi CG
FAU - Nascimento, Lucila Castanheira
AU  - Nascimento LC
FAU - Lima, Regina Aparecida Garcia de
AU  - Lima RA
LA  - por
PT  - Journal Article
PT  - Review
PT  - Systematic Review
TT  - A entrevista nas pesquisas qualitativas de enfermagem pediatrica.
PL  - Brazil
TA  - Rev Bras Enferm
JT  - Revista brasileira de enfermagem
JID - 7910105
MH  - *Interviews as Topic
MH  - *Nursing Research
MH  - *Pediatric Nursing
MH  - *Qualitative Research
RF  - 26
EDAT- 2010/06/04 06:00
MHDA- 2010/09/03 06:00
CRDT- 2010/06/04 06:00
PHST- 2009/07/06 00:00 [received]
PHST- 2010/03/20 00:00 [accepted]
PHST- 2010/06/04 06:00 [entrez]
PHST- 2010/06/04 06:00 [pubmed]
PHST- 2010/09/03 06:00 [medline]
AID - S0034-71672010000200020 [pii]
AID - 10.1590/s0034-71672010000200020 [doi]
PST - ppublish
SO  - Rev Bras Enferm. 2010 Mar-Apr;63(2):300-6. doi: 10.1590/s0034-71672010000200020.


PMID- 20520767
OWN - NLM
STAT- MEDLINE
DCOM- 20100907
LR  - 20211020
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 5
IP  - 5
DP  - 2010 May 26
TI  - The brain functional networks associated to human and animal suffering differ
      among omnivores, vegetarians and vegans.
PG  - e10847
LID - 10.1371/journal.pone.0010847 [doi]
AB  - Empathy and affective appraisals for conspecifics are among the hallmarks of
      social interaction. Using functional MRI, we hypothesized that vegetarians and
      vegans, who made their feeding choice for ethical reasons, might show brain
      responses to conditions of suffering involving humans or animals different from
      omnivores. We recruited 20 omnivore subjects, 19 vegetarians, and 21 vegans. The 
      groups were matched for sex and age. Brain activation was investigated using fMRI
      and an event-related design during observation of negative affective pictures of 
      human beings and animals (showing mutilations, murdered people, human/animal
      threat, tortures, wounds, etc.). Participants saw negative-valence scenes related
      to humans and animals, alternating with natural landscapes. During human negative
      valence scenes, compared with omnivores, vegetarians and vegans had an increased 
      recruitment of the anterior cingulate cortex (ACC) and inferior frontal gyrus
      (IFG). More critically, during animal negative valence scenes, they had decreased
      amygdala activation and increased activation of the lingual gyri, the left
      cuneus, the posterior cingulate cortex and several areas mainly located in the
      frontal lobes, including the ACC, the IFG and the middle frontal gyrus.
      Nonetheless, also substantial differences between vegetarians and vegans have
      been found responding to negative scenes. Vegetarians showed a selective
      recruitment of the right inferior parietal lobule during human negative scenes,
      and a prevailing activation of the ACC during animal negative scenes. Conversely,
      during animal negative scenes an increased activation of the inferior prefrontal 
      cortex was observed in vegans. These results suggest that empathy toward non
      conspecifics has different neural representation among individuals with different
      feeding habits, perhaps reflecting different motivational factors and beliefs.
FAU - Filippi, Massimo
AU  - Filippi M
AD  - Neuroimaging Research Unit, Institute of Experimental Neurology, Division of
      Neuroscience, Scientific Institute and University Hospital San Raffaele, Milan,
      Italy. filippi.massimo@hsr.it
FAU - Riccitelli, Gianna
AU  - Riccitelli G
FAU - Falini, Andrea
AU  - Falini A
FAU - Di Salle, Francesco
AU  - Di Salle F
FAU - Vuilleumier, Patrik
AU  - Vuilleumier P
FAU - Comi, Giancarlo
AU  - Comi G
FAU - Rocca, Maria A
AU  - Rocca MA
LA  - eng
PT  - Journal Article
DEP - 20100526
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Animals
MH  - Brain/*physiopathology
MH  - Brain Mapping
MH  - *Diet, Vegetarian
MH  - Empathy
MH  - *Feeding Behavior
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Nerve Net/*physiopathology
MH  - Photic Stimulation
MH  - Stress, Psychological/*physiopathology
MH  - Young Adult
PMC - PMC2877098
EDAT- 2010/06/04 06:00
MHDA- 2010/09/08 06:00
CRDT- 2010/06/04 06:00
PHST- 2010/03/19 00:00 [received]
PHST- 2010/05/05 00:00 [accepted]
PHST- 2010/06/04 06:00 [entrez]
PHST- 2010/06/04 06:00 [pubmed]
PHST- 2010/09/08 06:00 [medline]
AID - 10.1371/journal.pone.0010847 [doi]
PST - epublish
SO  - PLoS One. 2010 May 26;5(5):e10847. doi: 10.1371/journal.pone.0010847.


PMID- 20520213
OWN - NLM
STAT- MEDLINE
DCOM- 20100922
LR  - 20100603
IS  - 1535-2811 (Electronic)
IS  - 1535-2811 (Linking)
VI  - 9
IP  - 2
DP  - 2010 Jun
TI  - Pathway for the management of survivors of out-of-hospital cardiac arrest.
PG  - 49-54
LID - 10.1097/HPC.0b013e3181dc4d14 [doi]
AB  - The estimated number of out-of-hospital care arrest cases is about 300,000 per
      year in the United States. Two landmark studies published in 2002 demonstrated
      that the use of therapeutic hypothermia after cardiac arrest decreased mortality 
      and improved neurologic outcome. Based on these studies, the International
      Liaison Committee on Resuscitation and the American Heart Association recommended
      the use of therapeutic hypothermia after cardiac arrest. Therapeutic hypothermia 
      is defined as a controlled lowering of core body temperature to 32 degrees C to
      34 degrees C. This temperature goal represents the optimal balance between
      clinical effect and cardiovascular toxicity. Therapeutic hypothermia does require
      resources to implement-including device, close nursing care, and monitoring. It
      is important to select patients who have potential for benefit from this
      technique which is a limited resource and carries potential complications. A
      collaborative team approach involving physicians and nurses is critical for
      successful development and implementation of this kind of a protocol. In 2004,
      the "Advanced Cardiac Admission Program" was launched at the St. Luke's Roosevelt
      Hospital Center of Columbia University in New York. The program consists of a
      series of projects, which have been developed to bridge the gap between published
      guidelines and implementation during "real world" patient care. In this article, 
      we are reporting our latest project for the comprehensive management of survivors
      of out-of-hospital cardiac arrest. The pathway is divided into 3 steps: Step I,
      From the field through the emergency department into the cardiac catherization
      laboratory and to the critical care unit; Step II, Induced invasive hypothermia
      protocol in the critical care unit (this step is divided into 3 phases: 1,
      invasive cooling for the first 24 hours; 2, rewarming; 3, maintenance); Step III,
      Management post the rewarming phase including the recommendation for
      out-of-hospital therapy and the ethical decision to define goal of care. We hope 
      that this novel pathway will bridge the gap between the complex guidelines and
      the actual clinical practice and will improve the survival and neurologic
      condition of patients suffering cardiac arrest.
FAU - Herzog, Eyal
AU  - Herzog E
AD  - Division of Cardiology, St. Luke's-Roosevelt Hospital Center, College of
      Physicians and Surgeons, Columbia University, New York, NY 10025, USA.
      Eherzog@chpnet.org
FAU - Shapiro, Janet
AU  - Shapiro J
FAU - Aziz, Emad F
AU  - Aziz EF
FAU - Chong, Ji
AU  - Chong J
FAU - Hong, Mun K
AU  - Hong MK
FAU - Wiener, Dan
AU  - Wiener D
FAU - Lee, Richard
AU  - Lee R
FAU - Janis, Gregory
AU  - Janis G
FAU - Azrieli, Yevgeny
AU  - Azrieli Y
FAU - Velazquez, Barbara
AU  - Velazquez B
FAU - Lacdao, Leonida
AU  - Lacdao L
FAU - Mittal, Suneet
AU  - Mittal S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Crit Pathw Cardiol
JT  - Critical pathways in cardiology
JID - 101165286
SB  - IM
MH  - Cardiopulmonary Resuscitation
MH  - Clinical Protocols
MH  - *Critical Pathways
MH  - Emergency Service, Hospital
MH  - Heart Arrest/complications/*therapy
MH  - Humans
MH  - Hypothermia, Induced
MH  - Patient Care Team
MH  - Rewarming
MH  - Survivors
EDAT- 2010/06/04 06:00
MHDA- 2010/09/24 06:00
CRDT- 2010/06/04 06:00
PHST- 2010/06/04 06:00 [entrez]
PHST- 2010/06/04 06:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
AID - 10.1097/HPC.0b013e3181dc4d14 [doi]
AID - 00132577-201006000-00001 [pii]
PST - ppublish
SO  - Crit Pathw Cardiol. 2010 Jun;9(2):49-54. doi: 10.1097/HPC.0b013e3181dc4d14.


PMID- 20520042
OWN - NLM
STAT- MEDLINE
DCOM- 20100715
LR  - 20100603
IS  - 1938-808X (Electronic)
IS  - 1040-2446 (Linking)
VI  - 85
IP  - 5
DP  - 2010 May
TI  - Individual and social concerns in American surgical education: paying patients,
      prepaid health insurance, Medicare and Medicaid.
PG  - 854-62
LID - 10.1097/ACM.0b013e3181d7a08d [doi]
AB  - The education of the U.S. surgeon was traditionally based on a system in which
      surgeons-in-training cared for a population of largely indigent patients in a
      setting of graded responsibility. To ensure an ethically appropriate bargain,
      senior surgeons served as mentors, assumed ultimate responsibility for the
      patient, and supervised the surgical care of the ward patient by the surgical
      trainee. During the 20th century, changes in health care financing challenged
      this comfortable accommodation between charity care and medical education. As
      others have also written, the introduction of prepaid health insurance plans such
      as Blue Cross/Blue Shield in the early third of the century, the rapid expansion 
      of employment-based health benefits during World War II, and the enactment of the
      Medicare and Medicaid legislation under Titles XVIII and XIX of the Social
      Security Act all contributed to a dramatic reduction in hospital ward (i.e.,
      service) populations. The tension between education and patient care remains
      incompletely resolved; the proper balance between supervision and graded
      responsibility for the resident is ultimately worked out on an individual basis. 
      Newer issues facing U.S. surgical education, including the justifiable demand for
      greater transparency, are likely to upset this suspended truce and lead to
      renewed discussions about such fundamental concepts as the definition of the
      resident and the role of the patient in the education of future surgeons.
FAU - O'Shea, John S
AU  - O'Shea JS
AD  - Department of Surgery, Montefiore Medical Center, Bronx, New York 10467, USA.
      jsoshea@comcast.net
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - Acad Med
JT  - Academic medicine : journal of the Association of American Medical Colleges
JID - 8904605
SB  - IM
MH  - Education, Medical, Graduate/history/*trends
MH  - General Surgery/*education
MH  - History, 18th Century
MH  - History, 19th Century
MH  - History, 20th Century
MH  - Humans
MH  - *Internship and Residency
MH  - Medicaid/history/trends
MH  - Medicare/history/trends
MH  - Prepaid Health Plans/history
MH  - Public Policy
MH  - Reimbursement Mechanisms
MH  - Specialty Boards
MH  - United States
MH  - World War II
EDAT- 2010/06/04 06:00
MHDA- 2010/07/16 06:00
CRDT- 2010/06/04 06:00
PHST- 2010/06/04 06:00 [entrez]
PHST- 2010/06/04 06:00 [pubmed]
PHST- 2010/07/16 06:00 [medline]
AID - 10.1097/ACM.0b013e3181d7a08d [doi]
AID - 00001888-201005000-00034 [pii]
PST - ppublish
SO  - Acad Med. 2010 May;85(5):854-62. doi: 10.1097/ACM.0b013e3181d7a08d.


PMID- 20520021
OWN - NLM
STAT- MEDLINE
DCOM- 20100715
LR  - 20220408
IS  - 1938-808X (Electronic)
IS  - 1040-2446 (Linking)
VI  - 85
IP  - 5
DP  - 2010 May
TI  - Commentary: doctors without boundaries: the ethics of teacher-student
      relationships in academic medicine.
PG  - 752-5
LID - 10.1097/ACM.0b013e3181d7e016 [doi]
AB  - Possessed of both instinct and intellect, physician teachers are required to be
      respectful exemplars of professionalism and interpersonal ethics in all
      environments, be it the hospital, classroom, or outside the educational setting. 
      Sometimes, even while protecting the sanctity of the teacher-student
      relationship, they may surreptitiously find themselves in the throes of
      consensual intimacy, boundary violations, student exploitation, or other negative
      interpersonal and/or departmental dynamics. One may question how an academic can 
      consistently resolve this tension and summon the temperance, humility, charity,
      and restraint needed to subdue lust, pride, abuse, and incontinence in the
      workplace. One important answer may lie in an improved understanding of the moral
      necessity of social cooperation, fairness, reciprocity, and respect that is
      constitutive of the physician-teacher role. Although normative expectations and
      duties have been outlined in extant codes of ethics and conduct within academic
      medicine, to date, few training programs currently teach faculty and residents
      about the ethics of appropriate pedagogic and intimate relations between teaching
      staff and students, interns, residents, researchers, and other trainees. This
      essay highlights examples from history, literature, and medical ethics as one
      small step toward filling this void.
FAU - Larkin, Gregory Luke
AU  - Larkin GL
AD  - Department of Emergency Medicine, Yale University School of Medicine, New Haven, 
      Connecticut 06519-1315, USA. gluke.larkin@yale.edu
FAU - Mello, Michael J
AU  - Mello MJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Acad Med
JT  - Academic medicine : journal of the Association of American Medical Colleges
JID - 8904605
SB  - IM
MH  - Codes of Ethics
MH  - *Faculty, Medical
MH  - Humans
MH  - Leadership
MH  - Mentors
MH  - Professional Misconduct/*ethics
MH  - Sex Offenses/ethics
MH  - Societies, Medical
MH  - *Students, Medical
MH  - United States
EDAT- 2010/06/04 06:00
MHDA- 2010/07/16 06:00
CRDT- 2010/06/04 06:00
PHST- 2010/06/04 06:00 [entrez]
PHST- 2010/06/04 06:00 [pubmed]
PHST- 2010/07/16 06:00 [medline]
AID - 10.1097/ACM.0b013e3181d7e016 [doi]
AID - 00001888-201005000-00010 [pii]
PST - ppublish
SO  - Acad Med. 2010 May;85(5):752-5. doi: 10.1097/ACM.0b013e3181d7e016.


PMID- 20519969
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140514
LR  - 20190516
IS  - 1554-8600 (Print)
IS  - 1554-8600 (Linking)
VI  - 6
IP  - 9
DP  - 2010 Sep 12
TI  - Public health measures & individualized decision-making: The confluence of the
      H1N1 vaccine and Islamic bioethics.
LID - 12015 [pii]
AB  - Vaccinations are amongst the most cost-effective and successful public health
      interventions. During the H1N1 influenza pandemic public health organizations
      around the world mobilized to procure and deliver vaccinations to the at-risk
      populations in order to reduce spread of, and decrease morbidity and mortality
      from, the swine flu. With the focus on delivering vaccines at a population-level,
      state and national governmental agencies coordinated to procure vaccine supplies 
      within the United States. However all healthcare decisions trickle down to the
      individual level. In this essay I narrate the tensions and challenges I faced to 
      make decisions for myself and my family on whether we should get the H1N1
      vaccines, while being true to both religious values and medical science. At the
      end of the narration I reflect on ethical and policy questions we must address
      during public health vaccination efforts.
FAU - Padela, Aasim I
AU  - Padela AI
AD  - Department of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA;
      Robert Wood Johnson Foundation Clinical Scholars Program, Department of Internal 
      Medicine, University of Michigan, Ann Arbor, MI, USA. aasim@umich.edu.
LA  - eng
PT  - Journal Article
DEP - 20100912
PL  - United States
TA  - Hum Vaccin
JT  - Human vaccines
JID - 101265291
EDAT- 2010/06/04 06:00
MHDA- 2010/06/04 06:01
CRDT- 2010/06/04 06:00
PHST- 2010/06/04 06:00 [entrez]
PHST- 2010/06/04 06:00 [pubmed]
PHST- 2010/06/04 06:01 [medline]
AID - 12015 [pii]
AID - 10.4161/hv.6.9.12015 [doi]
PST - ppublish
SO  - Hum Vaccin. 2010 Sep 12;6(9). pii: 12015. doi: 10.4161/hv.6.9.12015. Epub 2010
      Sep 12.


PMID- 20519893
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20190710
IS  - 1662-2898 (Electronic)
IS  - 0079-6034 (Linking)
VI  - 95
DP  - 2010
TI  - Epinephrine (adrenaline) in anaphylaxis.
PG  - 211-222
LID - 10.1159/000315954 [doi]
AB  - Epinephrine (adrenaline) is universally recommended as the initial drug of choice
      for the treatment of anaphylaxis. No other medication has similar life-saving
      pharmacologic effects in multiple organ systems, including prevention and relief 
      of both upper and lower airway obstruction, and of shock. Failure to inject
      epinephrine promptly contributes to anaphylaxis fatalities. It is most effective 
      when given immediately after the onset of anaphylaxis symptoms. The initial
      recommended adult dose is 0.3-0.5 mg, injected intramuscularly in the
      anterolateral aspect of the mid-thigh. Injected by other routes, epinephrine
      appears to have a less satisfactory therapeutic window; for example, onset of
      action is potentially delayed when it is injected subcutaneously, and risk of
      adverse effects potentially increases when it is injected intravenously. The
      possibility of randomized, controlled trials of epinephrine in anaphylaxis should
      be considered. For ethical reasons, these trials will not be placebo-controlled. 
      They might involve comparison of one epinephrine dose versus another, or one
      route of epinephrine administration versus another. For first-aid treatment of
      people with anaphylaxis in the community, novel epinephrine formulations are
      being developed. These include epinephrine autoinjectors that are safer and
      easier to use, and epinephrine formulations that can be administered through
      non-invasive routes.
CI  - Copyright 2010 S. Karger AG, Basel.
FAU - Simons, F Estelle R
AU  - Simons FER
FAU - Simons, Keith J
AU  - Simons KJ
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100601
PL  - Switzerland
TA  - Chem Immunol Allergy
JT  - Chemical immunology and allergy
JID - 101183835
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Anaphylaxis/*drug therapy
MH  - Community Medicine
MH  - Drug Administration Routes
MH  - Drug Dosage Calculations
MH  - Epinephrine/*therapeutic use
MH  - Humans
MH  - Practice Guidelines as Topic
MH  - Randomized Controlled Trials as Topic
RF  - 50
EDAT- 2010/06/04 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/06/04 06:00
PHST- 2010/06/04 06:00 [entrez]
PHST- 2010/06/04 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - 000315954 [pii]
AID - 10.1159/000315954 [doi]
PST - ppublish
SO  - Chem Immunol Allergy. 2010;95:211-222. doi: 10.1159/000315954. Epub 2010 Jun 1.


PMID- 20519783
OWN - NLM
STAT- MEDLINE
DCOM- 20100923
LR  - 20190917
IS  - 0974-7559 (Electronic)
IS  - 0019-6061 (Linking)
VI  - 47
IP  - 5
DP  - 2010 May
TI  - Ethical challenges in the use of therapeutic hypothermia in Indian neonatal
      units.
PG  - 387-93
AB  - Trials in developed countries have shown that therapeutic hypothermia reduces the
      risk of death or severe disability in infants with neonatal encephalopathy.
      Cooling has been adopted as a standard of care in some parts of the world. Some
      Indian neonatal units have considered or even embarked upon cooling
      encephalopathic term newborn infants. In this article we discuss some of the
      potential ethical questions that should be considered before introducing
      therapeutic hypothermia in an Indian setting. Evidence from previous trials may
      not be relevant given significant differences in the epidemiology of neonatal
      encephalopathy in countries like India. There is a possibility that hypothermia
      would be ineffective or harmful. The most appropriate way to answer these
      concerns would be to perform a large randomized controlled trial of cooling in
      India. However, such trials will also raise potential ethical challenges. Cooling
      may also affect decisions about treatment withdrawal, and may create uncertainty 
      about prognosis. It may exacerbate ethical problems relating to lack of neonatal 
      intensive care bed space.
FAU - Wilkinson, Dominic J
AU  - Wilkinson DJ
AD  - Department of Public Health and Primary Health Care, the University of Oxford,
      Ethox Centre, UK. dominic.wilkinson@ethox.ox.ac.uk
FAU - Singh, Meharban
AU  - Singh M
FAU - Wyatt, John
AU  - Wyatt J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - India
TA  - Indian Pediatr
JT  - Indian pediatrics
JID - 2985062R
SB  - IM
MH  - Bayes Theorem
MH  - Humans
MH  - Hypothermia, Induced/*ethics
MH  - India
MH  - Infant, Newborn
MH  - *Intensive Care Units, Neonatal/ethics/standards
MH  - Randomized Controlled Trials as Topic/*ethics
EDAT- 2010/06/04 06:00
MHDA- 2010/09/24 06:00
CRDT- 2010/06/04 06:00
PHST- 2010/06/04 06:00 [entrez]
PHST- 2010/06/04 06:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
AID - 10.1007/s13312-010-0074-6 [doi]
PST - ppublish
SO  - Indian Pediatr. 2010 May;47(5):387-93. doi: 10.1007/s13312-010-0074-6.


PMID- 20519109
OWN - NLM
STAT- MEDLINE
DCOM- 20160105
LR  - 20100603
IS  - 0078-6608 (Print)
IS  - 0078-6608 (Linking)
VI  - 81
IP  - 2
DP  - 2010 Jun
TI  - [Teenager information on orthodontics with fixed appliances].
PG  - 139-45
LID - 10.1051/orthodfr/2010015 [doi]
AB  - Thoughts and questions are proposed on the reality of consent by adolescents.
      This reflection, ethical in nature, confronts the medico-legal facet of the care 
      contract, which is specific when minors are concerned, with the psychological
      aspect, so particular when an adolescent is involved. How do we treat adolescents
      who have not reached their majority? Beyond this quasi-philosophical questioning 
      on the inter-human care relationship, we put forward very practical elements
      towards answers.
CI  - EDP Sciences, SFODF, 2010.
FAU - Ceada, Julien
AU  - Ceada J
AD  - Faculte de Chirurgie Dentaire, 3 chemin des Maraichers, 31400 Toulouse, France.
      julienceada@hotmail.fr
FAU - Hamel, Olivier
AU  - Hamel O
FAU - Marchal-Sixou, Christine
AU  - Marchal-Sixou C
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - L'information de l'adolescent dans le cadre d'un traitement orthodontique
      multibague.
DEP - 20100603
PL  - France
TA  - Orthod Fr
JT  - L' Orthodontie francaise
JID - 0200547
SB  - IM
MH  - Adolescent
MH  - Humans
MH  - *Orthodontic Brackets
MH  - *Patient Education as Topic
EDAT- 2010/06/04 06:00
MHDA- 2016/01/06 06:00
CRDT- 2010/06/04 06:00
PHST- 2010/06/04 06:00 [entrez]
PHST- 2010/06/04 06:00 [pubmed]
PHST- 2016/01/06 06:00 [medline]
AID - 10.1051/orthodfr/2010015 [doi]
AID - or1013 [pii]
PST - ppublish
SO  - Orthod Fr. 2010 Jun;81(2):139-45. doi: 10.1051/orthodfr/2010015. Epub 2010 Jun 3.


PMID- 20518993
OWN - NLM
STAT- MEDLINE
DCOM- 20101007
LR  - 20100603
IS  - 1365-2923 (Electronic)
IS  - 0308-0110 (Linking)
VI  - 44
IP  - 5
DP  - 2010 May
TI  - The ABC framework for ethical decision making.
PG  - 502
LID - 10.1111/j.1365-2923.2010.03666.x [doi]
FAU - Marco, Catherine A
AU  - Marco CA
AD  - University of Toledo College of Medicine, 3045 Arlington Avenue, Mail Stop 1114, 
      Toledo, Ohio 43614, USA. Catherine.marco@utoledo.edu
FAU - Shriner, Constance
AU  - Shriner C
LA  - eng
PT  - Journal Article
PL  - England
TA  - Med Educ
JT  - Medical education
JID - 7605655
SB  - IM
MH  - Decision Making/*ethics
MH  - Education, Medical, Undergraduate/*methods
MH  - Ethics, Medical/*education
MH  - Humans
EDAT- 2010/06/04 06:00
MHDA- 2010/10/12 06:00
CRDT- 2010/06/04 06:00
PHST- 2010/06/04 06:00 [entrez]
PHST- 2010/06/04 06:00 [pubmed]
PHST- 2010/10/12 06:00 [medline]
AID - MED3666 [pii]
AID - 10.1111/j.1365-2923.2010.03666.x [doi]
PST - ppublish
SO  - Med Educ. 2010 May;44(5):502. doi: 10.1111/j.1365-2923.2010.03666.x.


PMID- 20518376
OWN - NLM
STAT- MEDLINE
DCOM- 20100706
LR  - 20161125
IS  - 1474-9114 (Print)
IS  - 1474-9114 (Linking)
VI  - 20
IP  - 2
DP  - 2010
TI  - Assisted reproduction: should egg and sperm donors be paid?
PG  - 69-71
AB  - Although in vitro fertilisation is now widely accepted, there is a shortage of
      donated eggs and many women in the UK are having to wait months and sometimes
      years for treatment by this method. Payment for donated eggs and sperm is not
      permitted at present in the UK. However, giving eggs is not risk-free and the
      donor may incur financial and time costs. The UK regulatory authority the Human
      Fertilisation and Embryology Authority (HFEA) is currently reviewing sperm, egg
      and embryo donation policies which it expects will conclude later this year. This
      article discusses the legal and ethical issues surrounding payment for egg and
      sperm donors and argues that the time has come for this to be permitted with
      appropriate safeguards established by the HFEA.
FAU - Flower, Dorothy
AU  - Flower D
AD  - Reynolds Porter Chamberlain LLP, London.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Fam Health Care
JT  - The journal of family health care
JID - 101142028
MH  - *Fees and Charges
MH  - Female
MH  - Humans
MH  - Male
MH  - Oocyte Donation/*economics/ethics/legislation & jurisprudence
MH  - Public Policy
MH  - Reproductive Techniques, Assisted/*economics/ethics/legislation & jurisprudence
MH  - *Semen
MH  - *Tissue Donors/ethics/legislation & jurisprudence
MH  - United Kingdom
EDAT- 2010/06/04 06:00
MHDA- 2010/07/07 06:00
CRDT- 2010/06/04 06:00
PHST- 2010/06/04 06:00 [entrez]
PHST- 2010/06/04 06:00 [pubmed]
PHST- 2010/07/07 06:00 [medline]
PST - ppublish
SO  - J Fam Health Care. 2010;20(2):69-71.


PMID- 20518244
OWN - NLM
STAT- MEDLINE
DCOM- 20100706
LR  - 20191210
IS  - 1259-4792 (Print)
IS  - 1259-4792 (Linking)
IP  - 254
DP  - 2010 May-Jun
TI  - [Taking care of a newborn suffering from dysmorphism].
PG  - 40-2
AB  - Taking care of a newborn suffering from dysmorphism tests nurses' professional
      ethics. Lack of awareness of the pathology and professional fragility can fuel
      the healthcare worker's moral conflict. A study carried out in neonatology shows 
      that the phantasmagoric imaginations of the healthcare worker heighten the unease
      while training and service culture contributes to self understanding and the
      easing of tensions.
FAU - Calas, Jean-Francois
AU  - Calas JF
AD  - CPOA, CH Sainte-Anne, Paris. calasjf@orange.fr
LA  - fre
PT  - Journal Article
TT  - Prendre soin d'un nouveau-ne atteint de dysmorphie.
PL  - France
TA  - Soins Pediatr Pueric
JT  - Soins. Pediatrie, puericulture
JID - 9604503
MH  - Adaptation, Psychological
MH  - *Attitude of Health Personnel
MH  - Conflict, Psychological
MH  - Humans
MH  - Infant, Newborn
MH  - Morals
MH  - Neonatal Nursing/ethics/methods
MH  - Nursing Methodology Research
MH  - Nursing Staff, Hospital/ethics/*psychology
MH  - Pierre Robin Syndrome/*nursing
MH  - Qualitative Research
MH  - Surveys and Questionnaires
EDAT- 2010/06/04 06:00
MHDA- 2010/07/07 06:00
CRDT- 2010/06/04 06:00
PHST- 2010/06/04 06:00 [entrez]
PHST- 2010/06/04 06:00 [pubmed]
PHST- 2010/07/07 06:00 [medline]
PST - ppublish
SO  - Soins Pediatr Pueric. 2010 May-Jun;(254):40-2.


PMID- 20517837
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20100602
IS  - 0041-4131 (Print)
IS  - 0041-4131 (Linking)
VI  - 88
IP  - 5
DP  - 2010 May
TI  - [The psychiatrist faced with an ordinance on request].
PG  - 363-5
AB  - The psychiatrist often receives ordinances on request to inspect the medical
      files of the patient. Does the response to this request constitutes a violation
      of the medical secrecy? The texts of law governing the ordinance on request do
      not oblige the doctor to give an answer and do not expose him to sanctions in
      case of justifiable refusal. Moreover, the code of ethics, the penal code and the
      law relating to the personal data protection prohibit the response to an
      ordinance on request. Thus, the communication of the medical files, in response
      to an ordinance on request is a violation of the medical secrecy and exposes the 
      psychiatrist to serious sanctions.
FAU - Elloumi, Hend
AU  - Elloumi H
AD  - Service Psychiatrie E, CHU Razi, La Manouba.
FAU - Haffani, Mohamed Fakhreddine
AU  - Haffani MF
FAU - Dakhlaoui, Olfa
AU  - Dakhlaoui O
LA  - fre
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - Le psychiatre face a une ordonnance sur requete.
PL  - Tunisia
TA  - Tunis Med
JT  - La Tunisie medicale
JID - 0413766
SB  - IM
MH  - Confidentiality/*legislation & jurisprudence
MH  - Humans
MH  - Male
MH  - *Medical Records
MH  - Mentally Ill Persons/legislation & jurisprudence
MH  - Middle Aged
MH  - Psychiatry/*legislation & jurisprudence
MH  - Tunisia
EDAT- 2010/06/03 06:00
MHDA- 2010/09/15 06:00
CRDT- 2010/06/03 06:00
PHST- 2010/06/03 06:00 [entrez]
PHST- 2010/06/03 06:00 [pubmed]
PHST- 2010/09/15 06:00 [medline]
AID - /article-medicale-tunisie.php?article=1341 [pii]
PST - ppublish
SO  - Tunis Med. 2010 May;88(5):363-5.


PMID- 20517795
OWN - NLM
STAT- MEDLINE
DCOM- 20100618
LR  - 20100602
IS  - 1438-9010 (Electronic)
IS  - 1438-9010 (Linking)
VI  - 182
IP  - 6
DP  - 2010 Jun
TI  - [MRI without radiologists--ethical aspects of population based studies with MRI
      imaging].
PG  - 469-71
LID - 10.1055/s-0029-1245453 [doi]
FAU - Puls, R
AU  - Puls R
FAU - Hamm, B
AU  - Hamm B
FAU - Hosten, N
AU  - Hosten N
LA  - ger
PT  - Editorial
TT  - MRT ohne Radiologen - ethische Aspekte bei bevolkerungsbasierten Studien mit
      MR-Untersuchungen.
DEP - 20100601
PL  - Germany
TA  - Rofo
JT  - RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin
JID - 7507497
SB  - IM
MH  - Brain/pathology/*physiopathology
MH  - Brain Diseases/*diagnosis/*physiopathology
MH  - Cost-Benefit Analysis
MH  - *Ethics, Medical
MH  - *Ethics, Research
MH  - Germany
MH  - Humans
MH  - Incidental Findings
MH  - Magnetic Resonance Imaging/economics/*ethics
MH  - Mass Screening/economics/ethics
MH  - National Health Programs/economics/ethics
MH  - Neurosciences/economics/*ethics
MH  - Patient Care Team/economics/*ethics
MH  - Physician-Patient Relations/ethics
MH  - Unnecessary Procedures/economics/*ethics
EDAT- 2010/06/03 06:00
MHDA- 2010/06/19 06:00
CRDT- 2010/06/03 06:00
PHST- 2010/06/03 06:00 [entrez]
PHST- 2010/06/03 06:00 [pubmed]
PHST- 2010/06/19 06:00 [medline]
AID - 10.1055/s-0029-1245453 [doi]
PST - ppublish
SO  - Rofo. 2010 Jun;182(6):469-71. doi: 10.1055/s-0029-1245453. Epub 2010 Jun 1.


PMID- 20517743
OWN - NLM
STAT- MEDLINE
DCOM- 20100820
LR  - 20100602
IS  - 1306-696X (Print)
VI  - 16
IP  - 3
DP  - 2010 May
TI  - Triage decisions of emergency physicians in Kocaeli and the principle of justice.
PG  - 203-9
AB  - BACKGROUND: We aimed to examine the accuracy of triage decision-making among
      emergency physicians, using a multiple casualty scenario. This will assist in
      determining the necessity of triage training, which is the foundation of
      emergency medical ethics. METHODS: A self-administered questionnaire including a 
      multiple casualty scenario requiring each casualty to be prioritized for
      treatments by Simple Triage and Rapid Treatment (START) was given to 110
      emergency physicians working at pre-hospital and hospital emergency services in
      Kocaeli. The differences between personal/professional characteristics and triage
      decisions were analyzed using chi-square test. RESULTS: Accurate triage decision 
      rates of the emergency physicians ranged from 83.6% to 90.0% for four immediate
      casualties, 26.4% to 78.2% for seven urgent casualties, 70.9% to 91.8% for four
      delayed casualties, and 82.7% to 97.3% for two dead cases. Personal and
      professional characteristics were found to be statistically significant in five
      cases (p<0.05). CONCLUSION: This study showed that emergency physicians tended to
      under-triage patients. This result and the discrepancy of the accuracy rates in
      urgent casualties revealed the necessity for improvement in medical-ethical
      decision-making in the training programs. This improvement will help in reducing 
      violation of the important duties of justice and of do no harm by the emergency
      physicians.
FAU - Ersoy, Nermin
AU  - Ersoy N
AD  - Department of History of Medicine & Medical Ethics, Faculty of Medicine, Kocaeli 
      University, Kocaeli, Turkey.
FAU - Akpinar, Aslihan
AU  - Akpinar A
LA  - eng
PT  - Journal Article
PL  - Turkey
TA  - Ulus Travma Acil Cerrahi Derg
JT  - Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency
      surgery : TJTES
JID - 101274231
SB  - IM
MH  - *Decision Making
MH  - *Disaster Planning
MH  - Emergency Medical Services/*statistics & numerical data
MH  - Emergency Service, Hospital/organization & administration
MH  - Humans
MH  - *Physicians
MH  - *Social Justice
MH  - *Triage
MH  - Turkey
EDAT- 2010/06/03 06:00
MHDA- 2010/08/21 06:00
CRDT- 2010/06/03 06:00
PHST- 2010/06/03 06:00 [entrez]
PHST- 2010/06/03 06:00 [pubmed]
PHST- 2010/08/21 06:00 [medline]
PST - ppublish
SO  - Ulus Travma Acil Cerrahi Derg. 2010 May;16(3):203-9.


PMID- 20517685
OWN - NLM
STAT- MEDLINE
DCOM- 20100913
LR  - 20100602
IS  - 0927-3042 (Print)
IS  - 0927-3042 (Linking)
VI  - 155
DP  - 2010
TI  - Ethicolegal aspects of cancer genetics.
PG  - 1-14
LID - 10.1007/978-1-4419-6033-7_1 [doi]
AB  - In the wake of efficacious preventive interventions based on hereditary cancer
      risk assessment, a number of ethical and legal challenges have emerged. These
      include issues such as appropriate testing of children and embryos, the "duty to 
      warn" relatives about familial risk, reproductive genetic testing, the risk of
      genetic discrimination, and equitable access to testing. These and other issues
      will be discussed within the framework of a bioethical model, with reference to
      recent case law.
FAU - Offit, Kenneth
AU  - Offit K
AD  - Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, NY
      10021, USA. offitk@mskcc.org
FAU - Thom, Peter
AU  - Thom P
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Cancer Treat Res
JT  - Cancer treatment and research
JID - 8008541
SB  - IM
MH  - Bioethics
MH  - Child
MH  - Female
MH  - Genetic Counseling
MH  - Genetic Testing/legislation & jurisprudence
MH  - Genetics/*legislation & jurisprudence
MH  - Genome, Human
MH  - Genomics/*legislation & jurisprudence/organization & administration
MH  - Humans
MH  - Male
MH  - Pregnancy
MH  - Prejudice
MH  - Prenatal Diagnosis
MH  - Risk Assessment
MH  - United States
RF  - 57
EDAT- 2010/06/03 06:00
MHDA- 2010/09/14 06:00
CRDT- 2010/06/03 06:00
PHST- 2010/06/03 06:00 [entrez]
PHST- 2010/06/03 06:00 [pubmed]
PHST- 2010/09/14 06:00 [medline]
AID - 10.1007/978-1-4419-6033-7_1 [doi]
PST - ppublish
SO  - Cancer Treat Res. 2010;155:1-14. doi: 10.1007/978-1-4419-6033-7_1.


PMID- 20517226
OWN - NLM
STAT- MEDLINE
DCOM- 20101025
LR  - 20181201
IS  - 1997-7298 (Print)
IS  - 1997-7298 (Linking)
VI  - 110
IP  - 3
DP  - 2010
TI  - [Effect of side-effects and complications caused by atypical neuroleptics on the 
      effectiveness of therapy in patients with schizophrenia].
PG  - 48-55
AB  - 434 patients were treated with clozapine, risperidone, olanzapine, quetiapine or 
      typical neuroleptics. Main types of undesirable effects (side-effects and
      complications) that affected the effectiveness of treatment were singled out. It 
      has been shown that the reduction of effectiveness may lead to the revision of
      treatment plan on life-saving indications or due to ethical considerations, the
      maintenance of therapeutic collaboration or the negative attitude of relatives to
      treatment. The data obtained suggest a different effect of side-effects on the
      effectiveness of treatment with atypical and typical antipsychotic drugs.
FAU - Danilov, D S
AU  - Danilov DS
LA  - rus
PT  - Journal Article
PL  - Russia (Federation)
TA  - Zh Nevrol Psikhiatr Im S S Korsakova
JT  - Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
JID - 9712194
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Dibenzothiazepines)
RN  - 12794-10-4 (Benzodiazepines)
RN  - 2S3PL1B6UJ (Quetiapine Fumarate)
RN  - J60AR2IKIC (Clozapine)
RN  - L6UH7ZF8HC (Risperidone)
RN  - N7U69T4SZR (Olanzapine)
SB  - IM
MH  - Adult
MH  - Antipsychotic Agents/*adverse effects/therapeutic use
MH  - Benzodiazepines/adverse effects/therapeutic use
MH  - Clozapine/adverse effects/therapeutic use
MH  - Dibenzothiazepines/adverse effects/therapeutic use
MH  - Humans
MH  - Olanzapine
MH  - Quetiapine Fumarate
MH  - Risperidone/adverse effects/therapeutic use
MH  - Schizophrenia/*drug therapy/physiopathology
MH  - Treatment Outcome
EDAT- 2010/06/03 06:00
MHDA- 2010/10/26 06:00
CRDT- 2010/06/03 06:00
PHST- 2010/06/03 06:00 [entrez]
PHST- 2010/06/03 06:00 [pubmed]
PHST- 2010/10/26 06:00 [medline]
PST - ppublish
SO  - Zh Nevrol Psikhiatr Im S S Korsakova. 2010;110(3):48-55.


PMID- 20516730
OWN - NLM
STAT- MEDLINE
DCOM- 20100830
LR  - 20100602
IS  - 1423-0291 (Electronic)
IS  - 1015-2008 (Linking)
VI  - 77
IP  - 3
DP  - 2010
TI  - Organization of a tumor bank: the experience of the National Cancer Institute of 
      Mexico.
PG  - 147-54
LID - 10.1159/000292648 [doi]
AB  - A tumor bank (TB) is an ordered collection of neoplastic samples, normal tissue, 
      and/or fluids preserved under optimal conditions, as well as storing patients'
      clinical information. The objective of this article is to outline the planning
      and logistics necessary for the functioning of the Instituto Nacional de
      Cancerologia (INCan) TB in Mexico City. For the planning and logistics of a TB,
      several technical, legal, medical, structural, and physical aspects were
      considered, which can be grouped under four headings: (1) design and structure,
      (2) equipping the area and informatics, (3) ethical-legal aspects, and (4) sample
      collection, preservation, and quality control. One crucial element of
      interinstitutional interest will be the transfer of these concepts to the
      different oncological centers, integrating in this manner a network that enables 
      the exploration of the different pathologies from therapeutic, epidemiological,
      and molecular points of view.
CI  - 2010 S. Karger AG, Basel.
FAU - Ruiz-Godoy, L
AU  - Ruiz-Godoy L
AD  - National Cancer Institute of Mexico (INCan), Mexico City, Mexico.
      lruizgodoy@gmail.com
FAU - Meneses-Garcia, A
AU  - Meneses-Garcia A
FAU - Suarez-Roa, L
AU  - Suarez-Roa L
FAU - Enriquez, V
AU  - Enriquez V
FAU - Lechuga-Rojas, R
AU  - Lechuga-Rojas R
FAU - Reyes-Lira, E
AU  - Reyes-Lira E
LA  - eng
PT  - Journal Article
DEP - 20100528
PL  - Switzerland
TA  - Pathobiology
JT  - Pathobiology : journal of immunopathology, molecular and cellular biology
JID - 9007504
SB  - IM
MH  - Academies and Institutes/economics/legislation & jurisprudence/*organization &
      administration/standards
MH  - Confidentiality
MH  - Facility Design and Construction
MH  - Humans
MH  - Informed Consent
MH  - Intellectual Property
MH  - Mexico
MH  - Neoplasms/*pathology
MH  - Organizational Objectives
MH  - Program Development
MH  - Quality Control
MH  - Specimen Handling/*standards
MH  - Tissue Banks/economics/legislation & jurisprudence/*organization &
      administration/standards
EDAT- 2010/06/03 06:00
MHDA- 2010/08/31 06:00
CRDT- 2010/06/03 06:00
PHST- 2009/08/31 00:00 [received]
PHST- 2009/12/03 00:00 [accepted]
PHST- 2010/06/03 06:00 [entrez]
PHST- 2010/06/03 06:00 [pubmed]
PHST- 2010/08/31 06:00 [medline]
AID - 000292648 [pii]
AID - 10.1159/000292648 [doi]
PST - ppublish
SO  - Pathobiology. 2010;77(3):147-54. doi: 10.1159/000292648. Epub 2010 May 28.


PMID- 20516447
OWN - NLM
STAT- MEDLINE
DCOM- 20100811
LR  - 20181201
IS  - 1527-7755 (Electronic)
IS  - 0732-183X (Linking)
VI  - 28
IP  - 19
DP  - 2010 Jul 1
TI  - Serious ethical dilemma of single-agent pegylated liposomal Doxorubicin employed 
      as a control arm in ovarian cancer chemotherapy trials.
PG  - e319-20; author reply e321-2
LID - 10.1200/JCO.2010.28.9934 [doi]
FAU - Markman, Maurie
AU  - Markman M
LA  - eng
PT  - Letter
PT  - Comment
DEP - 20100601
PL  - United States
TA  - J Clin Oncol
JT  - Journal of clinical oncology : official journal of the American Society of
      Clinical Oncology
JID - 8309333
RN  - 0 (liposomal doxorubicin)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 80168379AG (Doxorubicin)
SB  - IM
CON - J Clin Oncol. 2008 Feb 20;26(6):890-6. PMID: 18281662
MH  - Antineoplastic Combined Chemotherapy Protocols/adverse effects/*therapeutic use
MH  - Doxorubicin/administration & dosage/adverse effects/analogs & derivatives
MH  - Female
MH  - Humans
MH  - Ovarian Neoplasms/*drug therapy
MH  - Polyethylene Glycols/administration & dosage/adverse effects
MH  - Quality of Life
MH  - Randomized Controlled Trials as Topic
MH  - Skin Diseases/chemically induced
MH  - Treatment Outcome
EDAT- 2010/06/03 06:00
MHDA- 2010/08/12 06:00
CRDT- 2010/06/03 06:00
PHST- 2010/06/03 06:00 [entrez]
PHST- 2010/06/03 06:00 [pubmed]
PHST- 2010/08/12 06:00 [medline]
AID - JCO.2010.28.9934 [pii]
AID - 10.1200/JCO.2010.28.9934 [doi]
PST - ppublish
SO  - J Clin Oncol. 2010 Jul 1;28(19):e319-20; author reply e321-2. doi:
      10.1200/JCO.2010.28.9934. Epub 2010 Jun 1.


PMID- 20516357
OWN - NLM
STAT- MEDLINE
DCOM- 20110204
LR  - 20220311
IS  - 1931-7913 (Electronic)
IS  - 1931-7913 (Linking)
VI  - 9
IP  - 2
DP  - 2010 Summer
TI  - Promoting undergraduate interest, preparedness, and professional pursuit in the
      sciences: An outcomes evaluation of the SURE program at Emory University.
PG  - 119-32
LID - 10.1187/cbe.09-08-0057 [doi]
AB  - We report on an outcomes assessment of the Summer Undergraduate Research
      Experience (SURE) Program at Emory University in Atlanta, GA. Using follow-up
      survey data and academic transcripts, we gauge SURE's impact on levels of
      interest in, preparedness for, and actual pursuit of graduate study and
      professional careers in the sciences for the program's first 15 summer cohorts
      (1990-2004). Our follow-up survey indicated significant increases in all research
      preparedness skills considered, notably in ability to give a poster research
      presentation, to discuss research at a graduate school interview, and to apply
      research ethics principles. About a third of SURE graduates went on to complete a
      graduate degree >90% considered SURE as important or very important in their
      academic development. Respondents reported postprogram increases in the level of 
      interest in academic and research careers, and reported high levels of employment
      in science careers and job satisfaction. Regression analyses of Emory SURE
      participant transcripts revealed that participants take significantly more
      science courses as seniors and earn higher grades in those courses than
      nonparticipants. This trend held after correcting for indicators of prior
      interest (first-year course work, GPA, and math SAT scores), gender, and minority
      status. We also report on an external survey completed by SURE participants.
FAU - Junge, Benjamin
AU  - Junge B
AD  - Department of Anthropology, State University of New York/New Paltz, 12561, USA.
      jungeb@newpaltz.edu <jungeb@newpaltz.edu>
FAU - Quinones, Catherine
AU  - Quinones C
FAU - Kakietek, Jakub
AU  - Kakietek J
FAU - Teodorescu, Daniel
AU  - Teodorescu D
FAU - Marsteller, Pat
AU  - Marsteller P
LA  - eng
GR  - Howard Hughes Medical Institute/United States
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - CBE Life Sci Educ
JT  - CBE life sciences education
JID - 101269039
SB  - IM
MH  - *Career Choice
MH  - Education, Graduate/statistics & numerical data
MH  - *Program Evaluation
MH  - Regression Analysis
MH  - Research/education/statistics & numerical data
MH  - Science/*education
MH  - Students/statistics & numerical data
MH  - Teaching
MH  - *Universities
MH  - Workforce
PMC - PMC2879378
EDAT- 2010/06/03 06:00
MHDA- 2011/02/05 06:00
CRDT- 2010/06/03 06:00
PHST- 2010/06/03 06:00 [entrez]
PHST- 2010/06/03 06:00 [pubmed]
PHST- 2011/02/05 06:00 [medline]
AID - 9/2/119 [pii]
AID - 10.1187/cbe.09-08-0057 [doi]
PST - ppublish
SO  - CBE Life Sci Educ. 2010 Summer;9(2):119-32. doi: 10.1187/cbe.09-08-0057.


PMID- 20516296
OWN - NLM
STAT- MEDLINE
DCOM- 20100716
LR  - 20101215
IS  - 1930-7837 (Electronic)
IS  - 0022-0337 (Linking)
VI  - 74
IP  - 6
DP  - 2010 Jun
TI  - Ethics, empathy, and the education of dentists.
PG  - 567-78
AB  - Professional education in dentistry exists to educate good dentists-dentists
      equipped and committed to helping society gain the benefits of oral health. In
      achieving this intention, dental educators acknowledge that student dentists must
      acquire the complex knowledge base and the sophisticated perceptual-motor skills 
      of dentistry. The graduation of knowledgeable and skilled clinicians in dentistry
      is a necessary, but not sufficient, condition for ensuring quality oral health
      care. The further requirement is the commitment of graduates to applying their
      abilities with moral integrity: providing appropriate and quality care in their
      patients' best interest. Ultimately, good dentistry depends on individuals
      committed to treating their patients and society fairly, that is, ethically. This
      essay describes the historical basis for thinking about ethics from the
      perspective of human nature; describes how evolutionary ethics seeks to ground
      moral behavior in human emotion rather than primarily human reason; discusses the
      roots of morality in the behavior of animals, behavior that observed in humans
      would be described as empathy; characterizes empathy, discussing its imperative
      in caring for patients; and suggests what implications an empathy-mediated
      understanding of morality has for dental education.
FAU - Nash, David A
AU  - Nash DA
AD  - College of Dentistry, University of Kentucky, 800 Rose Street, Lexington, KY
      40536-0297, USA. danash@email.uky.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Dent Educ
JT  - Journal of dental education
JID - 8000150
SB  - IM
CIN - J Dent Educ. 2010 Dec;74(12):1275-7; author reply 1278-81. PMID: 21123495
MH  - Altruism
MH  - Animals
MH  - Clinical Competence
MH  - Conscience
MH  - Cooperative Behavior
MH  - Dental Care/psychology
MH  - Dentist-Patient Relations
MH  - Dentists/*ethics
MH  - *Education, Dental
MH  - Emotions
MH  - *Empathy
MH  - *Ethics, Dental/education
MH  - Female
MH  - Human Characteristics
MH  - Humans
MH  - Interpersonal Relations
MH  - Male
MH  - Mammals
MH  - Moral Obligations
MH  - Morals
MH  - Motivation
MH  - Quality of Health Care
MH  - Sex Factors
MH  - Social Behavior
EDAT- 2010/06/03 06:00
MHDA- 2010/07/17 06:00
CRDT- 2010/06/03 06:00
PHST- 2010/06/03 06:00 [entrez]
PHST- 2010/06/03 06:00 [pubmed]
PHST- 2010/07/17 06:00 [medline]
AID - 74/6/567 [pii]
PST - ppublish
SO  - J Dent Educ. 2010 Jun;74(6):567-78.


PMID- 20516238
OWN - NLM
STAT- MEDLINE
DCOM- 20101008
LR  - 20161020
IS  - 1526-3347 (Electronic)
IS  - 0191-9601 (Linking)
VI  - 31
IP  - 6
DP  - 2010 Jun
TI  - Ethics for the pediatrician: autonomy, beneficence, and rights.
PG  - 252-5
LID - 10.1542/pir.31-6-252 [doi]
FAU - Cummings, Christy L
AU  - Cummings CL
AD  - Department of Pediatrics, Division of Neonatology, Yale University School of
      Medicine, New Haven, Conn, USA.
FAU - Mercurio, Mark R
AU  - Mercurio MR
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Pediatr Rev
JT  - Pediatrics in review
JID - 8103046
SB  - IM
MH  - *Beneficence
MH  - Child
MH  - Child, Preschool
MH  - Decision Making
MH  - Humans
MH  - Parental Consent/ethics
MH  - Paternalism
MH  - Patient Rights/*ethics
MH  - Pediatrics/*ethics/standards
MH  - *Personal Autonomy
MH  - Physician-Patient Relations/ethics
MH  - Practice Patterns, Physicians'/ethics
MH  - Professional Autonomy
MH  - Quality Control
RF  - 16
EDAT- 2010/06/03 06:00
MHDA- 2010/10/12 06:00
CRDT- 2010/06/03 06:00
PHST- 2010/06/03 06:00 [entrez]
PHST- 2010/06/03 06:00 [pubmed]
PHST- 2010/10/12 06:00 [medline]
AID - 31/6/252 [pii]
AID - 10.1542/pir.31-6-252 [doi]
PST - ppublish
SO  - Pediatr Rev. 2010 Jun;31(6):252-5. doi: 10.1542/pir.31-6-252.


PMID- 20516106
OWN - NLM
STAT- MEDLINE
DCOM- 20100928
LR  - 20190709
IS  - 1943-4723 (Electronic)
IS  - 0002-8177 (Linking)
VI  - 141
IP  - 6
DP  - 2010 Jun
TI  - What ethical responsibilities do I have with regard to radiographs for my
      patients?
PG  - 718-20
FAU - Wentworth, Rod B
AU  - Wentworth RB
AD  - American Dental Association Council on Ethics, Bylaws and Judicial Affairs, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Am Dent Assoc
JT  - Journal of the American Dental Association (1939)
JID - 7503060
SB  - IM
CIN - J Am Dent Assoc. 2011 Jan;142(1):20; author reply 20. PMID: 21193761
MH  - Dentist-Patient Relations/*ethics
MH  - Dentists/*ethics
MH  - Emergency Treatment/ethics
MH  - *Ethics, Dental
MH  - Humans
MH  - Interprofessional Relations/ethics
MH  - Patient Participation
MH  - Radiation Dosage
MH  - Radiography, Dental/*ethics
MH  - Radiography, Dental, Digital/ethics
MH  - Risk Assessment
EDAT- 2010/06/03 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/06/03 06:00
PHST- 2010/06/03 06:00 [entrez]
PHST- 2010/06/03 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - S0002-8177(14)64752-8 [pii]
AID - 10.14219/jada.archive.2010.0264 [doi]
PST - ppublish
SO  - J Am Dent Assoc. 2010 Jun;141(6):718-20. doi: 10.14219/jada.archive.2010.0264.


PMID- 20515977
OWN - NLM
STAT- MEDLINE
DCOM- 20100924
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 256
IP  - 2
DP  - 2010 Aug
TI  - Differential diagnosis of azoospermia and etiologic classification of obstructive
      azoospermia: role of scrotal and transrectal US.
PG  - 493-503
LID - 10.1148/radiol.10091578 [doi]
AB  - PURPOSE: To evaluate the usefulness of scrotal and transrectal ultrasonography
      (US) in the differential diagnosis of azoospermia and the etiologic
      classification of obstructive azoospermia. MATERIALS AND METHODS: This study was 
      approved by the institutional ethics committee, and all patients provided written
      informed consent. Between April 2006 and November 2008, 100 infertile men (mean
      age, 32 years; range, 22-51 years) with azoospermia were evaluated at scrotal and
      transrectal US, with an emphasis on abnormal US findings of the seminal tract and
      measurement of testicular volume. On the basis of the results of percutaneous
      epididymal sperm aspiration, testicular fine-needle aspiration cytology, or
      testicular biopsy, 97 patients with azoospermia were divided into obstructive or 
      nonobstructive groups. The remaining three patients had Klinefelter syndrome and 
      did not undergo testicular biopsy. Receiver operating characteristic (ROC) curve 
      analysis was performed to evaluate the diagnostic performance of different
      indexes for discrimination between obstructive and nonobstructive azoospermia.
      Cases of obstructive azoospermia were further classified according to obstructive
      causes. RESULTS: Seminal tract abnormalities were more common in obstructive
      (92.2% [59 of 64 patients]) than in nonobstructive (2.8% [one of 36 patients]; P 
      < .001) azoospermia. Testicular volume was significantly larger for obstructive
      (median, 16.0 mL; range, 8.4-27.5 mL) than for nonobstructive (median, 8.6 mL;
      range, 0.9-21.0 mL; P < .001) azoospermia. The area under the ROC curve for
      discrimination between the groups through combined assessment of the seminal
      tract and testicular volume at scrotal and transrectal US was 0.96. Sensitivity, 
      specificity, and accuracy for combined assessment in discriminating between
      obstructive and nonobstructive azoospermia were 95.3% (61 of 64 patients), 97.2% 
      (35 of 36), and 96.0% (96 of 100), respectively. CONCLUSION: Scrotal US and
      transrectal US are effective imaging modalities for distinguishing obstructive
      from nonobstructive azoospermia and can provide meaningful diagnostic information
      for determining the etiologic classification of obstructive azoospermia.
FAU - Du, Jing
AU  - Du J
AD  - Department of Ultrasound, Shanghai Institute of Andrology, School of Medicine,
      Shanghai Jiaotong University, 1630 Dongfang Rd, Shanghai 200127, China.
FAU - Li, Feng Hua
AU  - Li FH
FAU - Guo, Yi Fen
AU  - Guo YF
FAU - Yang, Li Ming
AU  - Yang LM
FAU - Zheng, Ju Fen
AU  - Zheng JF
FAU - Chen, Bin
AU  - Chen B
FAU - Zhu, Jian Shan
AU  - Zhu JS
FAU - Liu, Qiang
AU  - Liu Q
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100601
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adult
MH  - Azoospermia/*classification/*diagnostic imaging
MH  - Diagnosis, Differential
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Rectum/*diagnostic imaging
MH  - Reproducibility of Results
MH  - Scrotum/*diagnostic imaging
MH  - Sensitivity and Specificity
MH  - Ultrasonography
MH  - Young Adult
EDAT- 2010/06/03 06:00
MHDA- 2010/09/25 06:00
CRDT- 2010/06/03 06:00
PHST- 2010/06/03 06:00 [entrez]
PHST- 2010/06/03 06:00 [pubmed]
PHST- 2010/09/25 06:00 [medline]
AID - radiol.10091578 [pii]
AID - 10.1148/radiol.10091578 [doi]
PST - ppublish
SO  - Radiology. 2010 Aug;256(2):493-503. doi: 10.1148/radiol.10091578. Epub 2010 Jun
      1.


PMID- 20515507
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1477-7517 (Electronic)
IS  - 1477-7517 (Linking)
VI  - 7
DP  - 2010 Jun 2
TI  - Risk behaviours among HIV positive injecting drug users in Myanmar: a case
      control study.
PG  - 12
LID - 10.1186/1477-7517-7-12 [doi]
AB  - BACKGROUND: The severity of HIV/AIDS pandemic linked to injecting drug use is one
      of the most worrying medical and social problems throughout the world in recent
      years. Myanmar has one of the highest prevalence rates of HIV among the IDUs in
      the region. AIM: The objective of the study was to determine the risk behaviours 
      among HIV positive injecting drug users in Myanmar. METHODS: A non matched case
      control study was conducted among 217 respondents registered with a non
      governmental organization's harm reduction center. 78 HIV positive IDUs were used
      as cases and 139 non HIV positive IDUs as controls. The study was conducted
      between April-May 2009. Data was analysed using SPSS version 15 and the study was
      ethically conducted. RESULTS: Factors like age, marital status, age first used
      drugs, drug use expenditure, reason for drug use, age first used injection were
      found to be significant. Other risk factors found significantly associated with
      HIV among IDU were education (OR 2.3), location of respondent (OR 2.4) type of
      syringe first used (OR 5.1), sharing syringe at the first injection (OR 4.5) and 
      failure of drug detoxification programme (OR 4.9). More HIV positive IDUs were
      returning used syringes in the centre (OR 3.3). CONCLUSIONS: Prudent measures
      such as access to sterile syringes and continuous health education programmes
      among IDUs and their sexual partners are required to reduce high risk behaviours 
      of IDUs in Myanmar.
FAU - Swe, Lin A
AU  - Swe LA
AD  - Beneficial Partner Group, Myanmar, 30A 2 Inya Road, Kamayut Township, Yangon,
      Myanmar. linaungswe@gmail.com.
FAU - Nyo, Kay K
AU  - Nyo KK
FAU - Rashid, Ak
AU  - Rashid A
LA  - eng
PT  - Journal Article
DEP - 20100602
PL  - England
TA  - Harm Reduct J
JT  - Harm reduction journal
JID - 101153624
PMC - PMC2890662
EDAT- 2010/06/03 06:00
MHDA- 2010/06/03 06:01
CRDT- 2010/06/03 06:00
PHST- 2009/10/29 00:00 [received]
PHST- 2010/06/02 00:00 [accepted]
PHST- 2010/06/03 06:00 [entrez]
PHST- 2010/06/03 06:00 [pubmed]
PHST- 2010/06/03 06:01 [medline]
AID - 1477-7517-7-12 [pii]
AID - 10.1186/1477-7517-7-12 [doi]
PST - epublish
SO  - Harm Reduct J. 2010 Jun 2;7:12. doi: 10.1186/1477-7517-7-12.


PMID- 20515286
OWN - NLM
STAT- MEDLINE
DCOM- 20100916
LR  - 20151119
IS  - 2166-1030 (Electronic)
IS  - 0085-591X (Linking)
VI  - 242
DP  - 2010
TI  - Approval of novel biomarkers: FDA's perspective and major requests.
PG  - 96-102
LID - 10.3109/00365513.2010.493415 [doi]
AB  - FDA has been regulating diagnostic tests (including biomarkers) since passage of 
      the Medical Device Amendments of 1976. Although always of interest as diagnostic 
      tools, biomarkers (particularly genetic/genomic) have become of increased
      interest because of their potential impact on the development and personalized
      use of drugs. Unfortunately, there seem to be uncertainties among translational
      researchers as to the specific analytical and clinical measurement criteria
      needed for the approval of these novel biomarkers. This meeting presentation
      describes the current FDA perspective and major requirements and data for the
      validation/approval of an in vitro diagnostic device (IVD) based on a biomarker. 
      The approval process for an IVD based on a biomarker used in the identification
      of a disease or condition (diagnosing, screening, monitoring) is well
      established, and is essentially identical to the process to generate sufficient
      analytical and clinical data for the approval of regular diagnostic devices. On
      the contrary, approvals for IVDs based on biomarker which may be designed to
      evaluate the efficacy or answer safety questions for new drug entities are less
      streamlined. The clinical studies are more complex, resulting in higher ethical
      standards, increased costs and requiring complex statistical evaluation. There is
      a small but growing literature on new models for co-development of drugs and
      diagnostics which will be discussed. Regulators like the FDA develop and bring a 
      flexible regulatory toolbox to the table and are committed to assuring that
      scientific and regulatory thresholds are tempered to assure rapid access to new
      technologies while protecting public health.
FAU - Scherf, Uwe
AU  - Scherf U
AD  - Office of In Vitro Diagnostic Device Evaluation and Safety, Center for Devices
      and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD,
      USA. Uwe.Scherf@fda.hhs.go
FAU - Becker, Robert
AU  - Becker R
FAU - Chan, Maria
AU  - Chan M
FAU - Hojvat, Sally
AU  - Hojvat S
LA  - eng
PT  - Journal Article
PL  - Norway
TA  - Scand J Clin Lab Invest Suppl
JT  - Scandinavian journal of clinical and laboratory investigation. Supplementum
JID - 2984789R
RN  - 0 (Biomarkers)
SB  - IM
MH  - *Biomarkers
MH  - Biotechnology/instrumentation/standards
MH  - Chemistry, Clinical/*standards
MH  - Clinical Laboratory Techniques/instrumentation/*standards
MH  - *Device Approval
MH  - Humans
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Randomized Controlled Trials as Topic/methods/standards
MH  - Reproducibility of Results
MH  - Risk Factors
MH  - United States
MH  - *United States Food and Drug Administration
EDAT- 2010/06/03 06:00
MHDA- 2010/09/18 06:00
CRDT- 2010/06/03 06:00
PHST- 2010/06/03 06:00 [entrez]
PHST- 2010/06/03 06:00 [pubmed]
PHST- 2010/09/18 06:00 [medline]
AID - 10.3109/00365513.2010.493415 [doi]
PST - ppublish
SO  - Scand J Clin Lab Invest Suppl. 2010;242:96-102. doi:
      10.3109/00365513.2010.493415.


PMID- 20514952
OWN - NLM
STAT- MEDLINE
DCOM- 20100617
LR  - 20220318
IS  - 0310-057X (Print)
IS  - 0310-057X (Linking)
VI  - 38
IP  - 3
DP  - 2010 May
TI  - Comparison of extent of sensory block following posterior and subcostal
      approaches to ultrasound-guided transversus abdominis plane block.
PG  - 452-60
AB  - Transversus abdominis plane block provides postoperative analgesia following
      abdominal surgery by targeting thoracolumbar nerves between the internal oblique 
      and transversus abdominis muscles. Posterior and subcostal approaches using
      ultrasound guidance have been described. However there have been inconsistent
      results in relation to the extent of the sensory block. This observational study 
      evaluated the distributions of sensory block following either a posterior or
      subcostal approach and the quality of analgesia achieved. Following ethics
      committee approval, 50 patients undergoing minimally invasive and major abdominal
      surgery were recruited. A total of 81 transversus abdominis plane blocks were
      performed preoperatively under real-time ultrasound guidance. Postoperatively,
      patients received multimodal analgesia including morphine via patient-controlled 
      pumps. Ninety-eight percent of patients had some degree of demonstrable sensory
      block and the dermatomal spread differed between posterior and subcostal
      approaches (P < 0.001). The posterior approach produced a median sensory block of
      three dermatomal segments (interquartile range 2 to 4), the most cephalad being
      T10 (interquartile range T9 to T10), while the subcostal approach blocked a
      median of four segments (interquartile range 3 to 5), the most cephalad being T8 
      (interquartile range T7 to T9, P < 0.001). Maximum dermatomal block distribution 
      was observed at 30 minutes and usually regressed by 24 hours. Median cumulative
      morphine consumption was 40.8 mg (interquartile range 17 to 50 mg) at 24 hours.
      Median pain scores at rest and with coughing were 20 (interquartile range 10 to
      35) and 50 (interquartile range 29 to 67) respectively at 24 hours. The posterior
      approach appears to be more appropriate for lower abdominal surgery and the
      subcostal approach better suited to upper abdominal surgery. Whichever approach
      is used, transversus abdominis plane block is only one component of a multimodal 
      analgesic technique.
FAU - Lee, T H W
AU  - Lee TH
AD  - Department of Anaesthesia, St. Vincent's Hospital, Melbourne, Victoria,
      Australia.
FAU - Barrington, M J
AU  - Barrington MJ
FAU - Tran, T M N
AU  - Tran TM
FAU - Wong, D
AU  - Wong D
FAU - Hebbard, P D
AU  - Hebbard PD
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Anaesth Intensive Care
JT  - Anaesthesia and intensive care
JID - 0342017
SB  - IM
MH  - Abdomen/*surgery
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Block/*methods
MH  - Pain, Postoperative/*therapy
MH  - Prospective Studies
MH  - Ultrasonics
EDAT- 2010/06/03 06:00
MHDA- 2010/06/18 06:00
CRDT- 2010/06/03 06:00
PHST- 2010/06/03 06:00 [entrez]
PHST- 2010/06/03 06:00 [pubmed]
PHST- 2010/06/18 06:00 [medline]
AID - 20090632 [pii]
AID - 10.1177/0310057X1003800307 [doi]
PST - ppublish
SO  - Anaesth Intensive Care. 2010 May;38(3):452-60. doi: 10.1177/0310057X1003800307.


PMID- 20514810
OWN - NLM
STAT- MEDLINE
DCOM- 20100803
LR  - 20100602
IS  - 1592-5986 (Print)
IS  - 1592-5986 (Linking)
VI  - 29
IP  - 1
DP  - 2010 Jan-Mar
TI  - [Memorandum for the management of clinical trials].
PG  - 26-40
AB  - A critical appraisal of the recent legislation on clinical trials is proposed,
      together with some reflections on the implications on the practice and principles
      of clinical experimentation. The possible role and contribution of Ethical
      Committees is discussed.
FAU - Valentini, Miriam
AU  - Valentini M
AD  - Unita di Gestione e Monitoraggio della Ricerca Clinica - Consorzio Mario Negri
      Sud, Santa Maria Imbaro, Chieti.
FAU - Pirozzoli, Maria Celeste
AU  - Pirozzoli MC
FAU - D'Alonzo, Daniela
AU  - D'Alonzo D
FAU - Pirozzi, Luisella
AU  - Pirozzi L
FAU - Anecchino, Caterina
AU  - Anecchino C
FAU - Tuzi, Francesca
AU  - Tuzi F
FAU - Romero, Marilena
AU  - Romero M
FAU - Nicolucci, Antonio
AU  - Nicolucci A
FAU - Strippoli, Giovanni F M
AU  - Strippoli GF
FAU - Belfiglio, Maurizio
AU  - Belfiglio M
FAU - Marchioli, Roberto
AU  - Marchioli R
FAU - Masciulli, Arianna
AU  - Masciulli A
FAU - Silletta, Maria G
AU  - Silletta MG
FAU - Tognoni, Gianni
AU  - Tognoni G
CN  - Gruppo di lavoro sulla sperimentazione clinica
LA  - ita
PT  - English Abstract
PT  - Journal Article
TT  - Pro-memoria per la gestione della sperimentazione clinica.
PL  - Italy
TA  - Assist Inferm Ric
JT  - Assistenza infermieristica e ricerca : AIR
JID - 100901776
MH  - Clinical Trials as Topic/*standards
MH  - Humans
MH  - Informed Consent
EDAT- 2010/06/03 06:00
MHDA- 2010/08/04 06:00
CRDT- 2010/06/03 06:00
PHST- 2010/06/03 06:00 [entrez]
PHST- 2010/06/03 06:00 [pubmed]
PHST- 2010/08/04 06:00 [medline]
PST - ppublish
SO  - Assist Inferm Ric. 2010 Jan-Mar;29(1):26-40.


PMID- 20514566
OWN - NLM
STAT- MEDLINE
DCOM- 20101029
LR  - 20100601
IS  - 1300-2163 (Print)
IS  - 1300-2163 (Linking)
VI  - 21
IP  - 2
DP  - 2010 Summer
TI  - [The treatment of bipolar disorder during pregnancy and the postpartum period].
PG  - 155-66
AB  - The prevalence of bipolar disorder (BD) in males and females is almost equal. The
      onset of BD in females typically occurs during the reproductive years,
      complicating its treatment. Although it was once believed that pregnancy prevents
      recurrence, studies have shown that recurrence is common and severe during
      pregnancy. On the other hand, the effects of pharmacological treatment on
      obstetrical outcome are not well known and some of these agents are considered
      teratogenic. Thus, the decision to treat pregnant patients with psychotropic
      agents requires solving an ethical dilemma. Risk-benefit decisions should be made
      while considering both the risk of relapse of BD and its morbidity, and the risk 
      of fetal exposure to psychotropic medications. Moreover, the risk of recurrence
      increases dramatically in the postpartum period. It is well known that all of the
      psychotropic medications studied enter the breast milk. Thus, their effects on
      infants should be considered while prescribing for a breastfeeding mother. The
      aim of this review was to discuss the safety profiles of the treatment options
      for pregnant and breastfeeding BD patients. Firstly, each medication's effects on
      organ dysgenesis, neonatal toxicity, and neurobehavioral development, and their
      associated adverse events during pregnancy and the postpartum period are
      discussed, with a focus on the emerging literature. Given this background,
      practical suggestions on tailoring treatment in BD patients, from preconception
      to breastfeeding are highlighted.
FAU - Guloksuz, Sinan
AU  - Guloksuz S
AD  - Bakirkoy Research and Training Hospital for Psychiatry, Neurology and
      Neurosurgery, Rasit Tahsin Mood Disorders Unit, Istanbul. sguloksuz@yahoo.com
FAU - Akdeniz, Fisun
AU  - Akdeniz F
FAU - Ince, Bahri
AU  - Ince B
FAU - Oral, Esat Timucin
AU  - Oral ET
LA  - tur
PT  - English Abstract
PT  - Journal Article
TT  - Gebe ve Lohusalarda Iki Uclu Bozuklugun Sagaltimi.
PL  - Turkey
TA  - Turk Psikiyatri Derg
JT  - Turk psikiyatri dergisi = Turkish journal of psychiatry
JID - 9425936
RN  - 0 (Psychotropic Drugs)
SB  - IM
MH  - Bipolar Disorder/epidemiology/*therapy
MH  - Breast Feeding/psychology
MH  - Female
MH  - Fetus/drug effects
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Milk, Human
MH  - Postpartum Period
MH  - Pregnancy
MH  - Pregnancy Complications/*psychology
MH  - Prevalence
MH  - Psychotropic Drugs/adverse effects/therapeutic use
MH  - Puerperal Disorders/*psychology/therapy
EDAT- 2010/06/02 06:00
MHDA- 2010/10/30 06:00
CRDT- 2010/06/02 06:00
PHST- 2010/06/02 06:00 [entrez]
PHST- 2010/06/02 06:00 [pubmed]
PHST- 2010/10/30 06:00 [medline]
AID - 759 [pii]
PST - ppublish
SO  - Turk Psikiyatri Derg. 2010 Summer;21(2):155-66.


PMID- 20514248
OWN - NLM
STAT- MEDLINE
DCOM- 20100820
LR  - 20211020
IS  - 0008-5286 (Print)
IS  - 0008-5286 (Linking)
VI  - 51
IP  - 3
DP  - 2010 Mar
TI  - An ethicist's commentary on the role of universities in the emergence of modern
      agriculture.
PG  - 238
FAU - Rollin, Bernard E
AU  - Rollin BE
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Vet J
JT  - The Canadian veterinary journal = La revue veterinaire canadienne
JID - 0004653
SB  - IM
MH  - Agriculture/*education
MH  - Humans
MH  - Students
MH  - Universities/*ethics
PMC - PMC2822367
EDAT- 2010/06/02 06:00
MHDA- 2010/08/21 06:00
CRDT- 2010/06/02 06:00
PHST- 2010/06/02 06:00 [entrez]
PHST- 2010/06/02 06:00 [pubmed]
PHST- 2010/08/21 06:00 [medline]
PST - ppublish
SO  - Can Vet J. 2010 Mar;51(3):238.


PMID- 20514084
OWN - NLM
STAT- MEDLINE
DCOM- 20100819
LR  - 20100601
IS  - 0048-0169 (Print)
IS  - 0048-0169 (Linking)
VI  - 58
IP  - 3
DP  - 2010 Jun
TI  - Legally protecting and compelling veterinarians in issues of animal abuse and
      domestic violence.
PG  - 114-20
LID - 10.1080/00480169.2010.67512 [doi]
AB  - The majority of veterinarians recognise their important role and responsibility
      to society and animal welfare in the detection and reporting of suspected abuse
      of animals and humans. In spite of the existing moral, ethical, and legal duties 
      applied to veterinarians, they face substantial barriers that prohibit them from 
      fulfilling their professional role in handling cases of suspected abuse. With
      increasing public and legal attention on issues of animal welfare, the
      non-fulfillment of these duties places the profession and its members at
      considerable risk of public criticism and adverse legal accountability. The issue
      is raised here that the veterinary profession in New Zealand needs to provide a
      clear policy statement and take pro-active measures that provide practical
      enforceable solutions to these existing barriers and legal risks. Such an
      initiative will assist in ensuring that all registered members consistently
      fulfil their obligations, and are legally protected while doing so. Veterinary
      counterparts overseas already provide a legislative immunity for their
      veterinarians who report suspected abuse as part of a mandated duty to report.
      Implementation of such a duty has significant benefits for all veterinarians,
      including the requirement for education and effective support systems. In the
      absence of such a mandatory duty, intermediary measures can be introduced,
      demonstrating social responsibility and commitment by the profession to their
      existing duty of care.
FAU - Robertson, I A
AU  - Robertson IA
AD  - International Animal Law, PO Box 106231, Auckland 1143, New Zealand.
      director@animal-law.biz
LA  - eng
PT  - Journal Article
PL  - England
TA  - N Z Vet J
JT  - New Zealand veterinary journal
JID - 0021406
SB  - IM
MH  - Animal Welfare/ethics/*legislation & jurisprudence
MH  - Animals
MH  - Animals, Domestic
MH  - Domestic Violence/ethics/*legislation & jurisprudence
MH  - Humans
MH  - Mandatory Reporting/*ethics
MH  - New Zealand
MH  - Public Policy
MH  - Veterinarians/*ethics/*legislation & jurisprudence
EDAT- 2010/06/02 06:00
MHDA- 2010/08/20 06:00
CRDT- 2010/06/02 06:00
PHST- 2010/06/02 06:00 [entrez]
PHST- 2010/06/02 06:00 [pubmed]
PHST- 2010/08/20 06:00 [medline]
AID - 10.1080/00480169.2010.67512 [doi]
PST - ppublish
SO  - N Z Vet J. 2010 Jun;58(3):114-20. doi: 10.1080/00480169.2010.67512.


PMID- 20513797
OWN - NLM
STAT- MEDLINE
DCOM- 20100909
LR  - 20161125
IS  - 1464-3790 (Electronic)
IS  - 0967-0742 (Linking)
VI  - 18
IP  - 2
DP  - 2010 Spring
TI  - Direct-to-consumer genetic testing: ethical-legal perspectives and practical
      considerations.
PG  - 213-38
LID - 10.1093/medlaw/fwq011 [doi]
FAU - Tamir, Sivan
AU  - Tamir S
AD  - The Gertner Institute for Epidemiology and Health Policy Research.
      sivant@gertner.health.gov.il
LA  - eng
PT  - Journal Article
PL  - England
TA  - Med Law Rev
JT  - Medical law review
JID - 9308945
SB  - IM
MH  - Adolescent
MH  - Child
MH  - *Community Participation
MH  - Genetic Testing/*ethics/*legislation & jurisprudence
MH  - Health Services Accessibility/*legislation & jurisprudence
MH  - Humans
EDAT- 2010/06/02 06:00
MHDA- 2010/09/10 06:00
CRDT- 2010/06/02 06:00
PHST- 2010/06/02 06:00 [entrez]
PHST- 2010/06/02 06:00 [pubmed]
PHST- 2010/09/10 06:00 [medline]
AID - fwq011 [pii]
AID - 10.1093/medlaw/fwq011 [doi]
PST - ppublish
SO  - Med Law Rev. 2010 Spring;18(2):213-38. doi: 10.1093/medlaw/fwq011.


PMID- 20513232
OWN - NLM
STAT- MEDLINE
DCOM- 20101029
LR  - 20220317
IS  - 1873-4286 (Electronic)
IS  - 1381-6128 (Linking)
VI  - 16
IP  - 22
DP  - 2010
TI  - Randomized clinical trials in children--ethical and methodological issues.
PG  - 2407-15
AB  - Randomization is an internationally accepted methodological tool used to perform 
      sound clinical research. To ensure the clinical value of medical interventions,
      both evidence based medicine and new drug approvals require that randomized
      controlled trials (RCT) be conducted. Randomization prevents the manipulation of 
      participant allocation and balances unknown confounders in a way no other method 
      can. The gold standard RCT, however, is complex to conduct and requires
      significant financial and structural resources. In consequence, drug development 
      and registration are primarily driven by the pharmaceutical industry. Within the 
      field of pediatrics, we need high quality research tailored to children in order 
      to reduce off-label use and to ensure that we expose children only to effective
      and, above all, safe drug treatments. The American and European regulatory
      authorities now offer programs to support such studies and clinical researchers
      and pharmaceutical industries are obliged to put them into practice in the best
      interest of the children. Issues relating to feasibility as well as ethical
      issues must be born in mind when planning RCTs in child populations. Obtaining
      informed assent from children in an adequate manner is one of several key
      elements. Moreover, it is essential to ensure equipoise before conducting a
      trial. Thus, issues relating to acceptability can be addressed and the
      discrimination of treatment groups within RCTs can be prevented. This narrative
      review addresses ethical and methodological aspects of RCTs in adults and
      especially in children and includes a quantitative analysis, which explores
      issues relating to the publication of RCTs.
FAU - Henschel, A D
AU  - Henschel AD
AD  - University Children's Hospital Muenster, Department of Pediatric Hematology and
      Oncology, Albert Schweitzer-Strasse 33, 48149 Muenster, Germany.
FAU - Rothenberger, L G
AU  - Rothenberger LG
FAU - Boos, J
AU  - Boos J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Curr Pharm Des
JT  - Current pharmaceutical design
JID - 9602487
SB  - IM
MH  - Child
MH  - *Ethics, Medical
MH  - Humans
MH  - Publishing/trends
MH  - *Randomized Controlled Trials as Topic/ethics/methods/standards
MH  - Serial Publications
MH  - Therapeutic Human Experimentation/*ethics
EDAT- 2010/06/02 06:00
MHDA- 2010/10/30 06:00
CRDT- 2010/06/02 06:00
PHST- 2010/04/30 00:00 [received]
PHST- 2010/05/19 00:00 [accepted]
PHST- 2010/06/02 06:00 [entrez]
PHST- 2010/06/02 06:00 [pubmed]
PHST- 2010/10/30 06:00 [medline]
AID - BSP/CPD/E-Pub/000121 [pii]
AID - 10.2174/138161210791959854 [doi]
PST - ppublish
SO  - Curr Pharm Des. 2010;16(22):2407-15. doi: 10.2174/138161210791959854.


PMID- 20513231
OWN - NLM
STAT- MEDLINE
DCOM- 20101029
LR  - 20190728
IS  - 1873-4286 (Electronic)
IS  - 1381-6128 (Linking)
VI  - 16
IP  - 22
DP  - 2010
TI  - Safeguarding children's rights in psychopharmacological research: ethical and
      legal issues.
PG  - 2398-406
AB  - OBJECTIVE: Research on psychopharmacological treatment in children and
      adolescents is the subject of ongoing ethical discussion, as minors with mental
      disorders constitute a vulnerable patient group. Considering the important
      legislative changes in pediatric research over the past decade in both the US and
      Western Europe, there is a need to review recent developments in this area.
      METHOD: Based on a systematic literature review, a hermeneutical analysis
      focusing the main issues of ethics in child and adolescent psychopharmacology is 
      provided. Legal and regulatory aspects of psychopharmacological research in
      children are compared between the US and Europe. Relevant issues were informed
      assent and consent to research participation, minimal risk and burden of
      research, ethics of pharmacogenetics, research on "me-too" medications, and
      justice in global research. Additionally, the concern about undue influence of
      financial interests in research is also addressed. CONCLUSION: Incentives for the
      conduct of clinical trials with children comparable to those contained in US
      legislation are now provided in the EU. Research to develop "me-too" preparations
      may have no significant benefit for children, but can cause research burden and
      detract from clinically more important projects by utilizing limited investigator
      time and patient resources. Thus far, pharmacogenetic studies may bring more
      individualized treatment approaches into child psychiatry but they remain at
      present a promise for the future. Finally, the issues of avoiding undue influence
      from funders and conflicts of interest remain a prominent concern which can be
      solved by declaring conflicts and publishing all results of studies extensively.
FAU - Kolch, Michael
AU  - Kolch M
AD  - Department of Child and Adolescent Psychiatry and Psychotherapy, University
      Hospital of Ulm, Steinhovelstr.5, 89075 Ulm, Germany.
      michael.koelch@uniklinik-ulm.de
FAU - Ludolph, Andrea G
AU  - Ludolph AG
FAU - Plener, Paul L
AU  - Plener PL
FAU - Fangerau, Heiner
AU  - Fangerau H
FAU - Vitiello, Benedetto
AU  - Vitiello B
FAU - Fegert, Joerg M
AU  - Fegert JM
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
PL  - United Arab Emirates
TA  - Curr Pharm Des
JT  - Current pharmaceutical design
JID - 9602487
SB  - IM
MH  - Adolescent
MH  - *Biomedical Research/ethics/legislation & jurisprudence/methods
MH  - Child
MH  - *Clinical Trials as Topic/ethics/legislation & jurisprudence
MH  - Codes of Ethics
MH  - Conflict of Interest/legislation & jurisprudence
MH  - Ethics, Medical
MH  - Europe
MH  - Humans
MH  - Legislation, Medical
MH  - Parental Consent/ethics/legislation & jurisprudence
MH  - *Patient Rights/ethics/legislation & jurisprudence
MH  - *Psychopharmacology/ethics/legislation & jurisprudence
MH  - Risk
MH  - United States
EDAT- 2010/06/02 06:00
MHDA- 2010/10/30 06:00
CRDT- 2010/06/02 06:00
PHST- 2010/04/30 00:00 [received]
PHST- 2010/05/21 00:00 [accepted]
PHST- 2010/06/02 06:00 [entrez]
PHST- 2010/06/02 06:00 [pubmed]
PHST- 2010/10/30 06:00 [medline]
AID - BSP/CPD/E-Pub/000122 [pii]
AID - 10.2174/138161210791959881 [doi]
PST - ppublish
SO  - Curr Pharm Des. 2010;16(22):2398-406. doi: 10.2174/138161210791959881.


PMID- 20513226
OWN - NLM
STAT- MEDLINE
DCOM- 20101029
LR  - 20190728
IS  - 1873-4286 (Electronic)
IS  - 1381-6128 (Linking)
VI  - 16
IP  - 22
DP  - 2010
TI  - Postnatal brain development and psychotropic drugs. Effects on animals and animal
      models of depression and attention-deficit/hyperactivity disorder.
PG  - 2474-83
AB  - In recent years an increased use of psychotropic medication in children has been 
      observed, but little is known about the influence of this medication on brain
      maturation. Probably, because of methodological problems and/or ethical aspects. 
      It means that only naturalistic observational studies might allow to get some
      insight in humans. But even animal studies touching this issue are scarce and
      heterogeneous. Nevertheless, postnatal brain development is highly sensitive to
      the effects of psychotropic drugs, either in the short- and/or long-term.
      Therefore, more and better information is needed. The main targets of
      psychotropic drugs are the monoaminergic transmitter systems that are related to 
      brain networks for motor behavior, motivation, emotion, and cognition. In order
      to elucidate the mechanisms of drug development interactions and their long-term 
      consequences on brain and behavior, animal studies might provide a good basis for
      a better understanding and guidance of research in humans. Hence, this article
      reviews the possible influence of those psychotropic drugs on postnatal brain
      development in animals (mostly rats and rodents) which are widely used to treat
      common psychiatric disorders in children and adolescents like depression and
      attention-deficit/ hyperactivity disorder (ADHD). Moreover this review refers to 
      the obvious problems of the available animal studies (including experimental
      animal models of child psychiatric disorders) which seem to be of limited value
      in translating experimental knowledge to the complexity of clinical understanding
      and practice.
FAU - Bock, Nathalie
AU  - Bock N
AD  - University of Goettingen, Germany, Department of Child and Adolescent Psychiatry,
      Von-Siebold-Str. 5, 37075 Goettingen, Germany. nbock@gwdg.de
FAU - Gerlach, Manfred
AU  - Gerlach M
FAU - Rothenberger, Aribert
AU  - Rothenberger A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Pharm Des
JT  - Current pharmaceutical design
JID - 9602487
RN  - 0 (Psychotropic Drugs)
SB  - IM
MH  - *Aging/metabolism/pathology
MH  - Animals
MH  - Attention Deficit Disorder with Hyperactivity/*drug therapy/physiopathology
MH  - Brain/*drug effects/growth & development/metabolism/pathology
MH  - Depression/*drug therapy/physiopathology
MH  - *Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Psychotropic Drugs/*adverse effects/therapeutic use
EDAT- 2010/06/02 06:00
MHDA- 2010/10/30 06:00
CRDT- 2010/06/02 06:00
PHST- 2010/04/30 00:00 [received]
PHST- 2010/05/19 00:00 [accepted]
PHST- 2010/06/02 06:00 [entrez]
PHST- 2010/06/02 06:00 [pubmed]
PHST- 2010/10/30 06:00 [medline]
AID - BSP/CPD/E-Pub/000127 [pii]
AID - 10.2174/138161210791959836 [doi]
PST - ppublish
SO  - Curr Pharm Des. 2010;16(22):2474-83. doi: 10.2174/138161210791959836.


PMID- 20513116
OWN - NLM
STAT- MEDLINE
DCOM- 20100621
LR  - 20220408
IS  - 1096-8652 (Electronic)
IS  - 0361-8609 (Linking)
VI  - 85
IP  - 6
DP  - 2010 Jun
TI  - The risks and benefits of long-term use of hydroxyurea in sickle cell anemia: A
      17.5 year follow-up.
PG  - 403-8
LID - 10.1002/ajh.21699 [doi]
AB  - A randomized, controlled clinical trial established the efficacy and safety of
      short-term use of hydroxyurea in adult sickle cell anemia. To examine the risks
      and benefits of long-term hydroxyurea usage, patients in this trial were followed
      for 17.5 years during which they could start or stop hydroxyurea. The purpose of 
      this follow-up was to search for adverse outcomes and estimate mortality. For
      each outcome and for mortality, exact 95% confidence intervals were calculated,
      or tests were conducted at alpha = 0.05 level (P-value <0.05 for statistical
      significance). Although the death rate in the overall study cohort was high
      (43.1%; 4.4 per 100 person-years), mortality was reduced in individuals with
      long-term exposure to hydroxyurea. Survival curves demonstrated a significant
      reduction in deaths with long-term exposure. Twenty-four percent of deaths were
      due to pulmonary complications; 87.1% occurred in patients who never took
      hydroxyurea or took it for <5 years. Stroke, organ dysfunction, infection, and
      malignancy were similar in all groups. Our results, while no longer the product
      of a randomized study because of the ethical concerns of withholding an
      efficacious treatment, suggest that long-term use of hydroxyurea is safe and
      might decrease mortality.
CI  - 2010 Wiley-Liss, Inc.
FAU - Steinberg, Martin H
AU  - Steinberg MH
AD  - Department of Medicine, Boston University School of Medicine, Boston Medical
      Center, Massachusetts, USA. mhsteinb@bu.edu <mhsteinb@bu.edu>
FAU - McCarthy, William F
AU  - McCarthy WF
FAU - Castro, Oswaldo
AU  - Castro O
FAU - Ballas, Samir K
AU  - Ballas SK
FAU - Armstrong, F Danny
AU  - Armstrong FD
FAU - Smith, Wally
AU  - Smith W
FAU - Ataga, Kenneth
AU  - Ataga K
FAU - Swerdlow, Paul
AU  - Swerdlow P
FAU - Kutlar, Abdullah
AU  - Kutlar A
FAU - DeCastro, Laura
AU  - DeCastro L
FAU - Waclawiw, Myron A
AU  - Waclawiw MA
CN  - Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia and
      MSH Patients' Follow-Up
LA  - eng
GR  - N01 HB067129/HB/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Am J Hematol
JT  - American journal of hematology
JID - 7610369
RN  - X6Q56QN5QC (Hydroxyurea)
SB  - IM
CIN - Am J Hematol. 2010 Jun;85(6):401-2. PMID: 20513115
MH  - Adolescent
MH  - Adult
MH  - Anemia, Sickle Cell/complications/*drug therapy/mortality
MH  - DNA Damage
MH  - Drug Utilization
MH  - Early Termination of Clinical Trials
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hydroxyurea/adverse effects/*therapeutic use
MH  - Kidney Diseases/mortality
MH  - Liver Diseases/mortality
MH  - Lung Diseases/mortality
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/mortality
MH  - *Practice Patterns, Physicians'
MH  - Prospective Studies
MH  - Risk Assessment
MH  - Sepsis/mortality
MH  - Statistics, Nonparametric
MH  - Stroke/mortality
MH  - Survival Analysis
MH  - Young Adult
PMC - PMC2879711
MID - NIHMS198614
IR  - Orringer E
FIR - Orringer, E
IR  - Ataga K
FIR - Ataga, K
IR  - Jones S
FIR - Jones, S
IR  - Strayhorn D
FIR - Strayhorn, D
IR  - DeCastro L
FIR - DeCastro, L
IR  - Rosse W
FIR - Rosse, W
IR  - Phillips G
FIR - Phillips, G
IR  - Peace D
FIR - Peace, D
IR  - Johnson-Telfair A
FIR - Johnson-Telfair, A
IR  - Kutlar A
FIR - Kutlar, A
IR  - Daitch L
FIR - Daitch, L
IR  - Milner P
FIR - Milner, P
IR  - Tracy A
FIR - Tracy, A
IR  - Ballas SK
FIR - Ballas, S K
IR  - Valdez S
FIR - Valdez, S
IR  - Allen GE
FIR - Allen, G E
IR  - Moshang J
FIR - Moshang, J
IR  - Scott B
FIR - Scott, B
IR  - Bigelow C
FIR - Bigelow, C
IR  - Steinberg M
FIR - Steinberg, M
IR  - Anderson A
FIR - Anderson, A
IR  - Sabahi V
FIR - Sabahi, V
IR  - Armstrong D
FIR - Armstrong, D
IR  - Harrington T
FIR - Harrington, T
IR  - Labrousse W
FIR - Labrousse, W
IR  - Pegelow C
FIR - Pegelow, C
IR  - Temple D
FIR - Temple, D
IR  - Case E
FIR - Case, E
IR  - Harrell R
FIR - Harrell, R
IR  - Childerie S
FIR - Childerie, S
IR  - Embury S
FIR - Embury, S
IR  - Schmidt B
FIR - Schmidt, B
IR  - Davies D
FIR - Davies, D
IR  - Saunthararajah Y
FIR - Saunthararajah, Y
IR  - Koshy M
FIR - Koshy, M
IR  - Talischy-Zahed N
FIR - Talischy-Zahed, N
IR  - Dorn L
FIR - Dorn, L
IR  - Pendarvis G
FIR - Pendarvis, G
IR  - McGee M
FIR - McGee, M
IR  - Telfer M
FIR - Telfer, M
IR  - Davis A
FIR - Davis, A
IR  - Castro O
FIR - Castro, O
IR  - Onyekwere OC
FIR - Onyekwere, O C
IR  - Nwokolo C
FIR - Nwokolo, C
IR  - Finke H
FIR - Finke, H
IR  - Perlin E
FIR - Perlin, E
IR  - Siteman J
FIR - Siteman, J
IR  - Bryan M
FIR - Bryan, M
IR  - Saunders T
FIR - Saunders, T
IR  - Barber Y
FIR - Barber, Y
IR  - Gascon P
FIR - Gascon, P
IR  - di Paolo P
FIR - di Paolo, P
IR  - Gargiulo S
FIR - Gargiulo, S
IR  - Eckman J
FIR - Eckman, J
IR  - Carter-Randall E
FIR - Carter-Randall, E
IR  - Bailey JH
FIR - Bailey, J H
IR  - Platt A
FIR - Platt, A
IR  - Waller L
FIR - Waller, L
IR  - Ramirez G
FIR - Ramirez, G
IR  - Knors V
FIR - Knors, V
IR  - Hernandez S
FIR - Hernandez, S
IR  - Rodriguez EM
FIR - Rodriguez, E M
IR  - Wilkes E
FIR - Wilkes, E
IR  - Vichinsky E
FIR - Vichinsky, E
IR  - Hagar W
FIR - Hagar, W
IR  - Hoehner C
FIR - Hoehner, C
IR  - Hackney-Stevens E
FIR - Hackney-Stevens, E
IR  - Claster S
FIR - Claster, S
IR  - Earles A
FIR - Earles, A
IR  - Kleman K
FIR - Kleman, K
IR  - McLaughlin K
FIR - McLaughlin, K
IR  - Smith W
FIR - Smith, W
IR  - White L
FIR - White, L
IR  - Swerdlow P
FIR - Swerdlow, P
IR  - Maddox B
FIR - Maddox, B
IR  - Usry L
FIR - Usry, L
IR  - Brenner A
FIR - Brenner, A
IR  - Williams K
FIR - Williams, K
IR  - O'Brien R
FIR - O'Brien, R
IR  - Genther K
FIR - Genther, K
IR  - Shurin S
FIR - Shurin, S
IR  - Berman B
FIR - Berman, B
IR  - Chiarucci K
FIR - Chiarucci, K
IR  - Keverline L
FIR - Keverline, L
IR  - Olivieri N
FIR - Olivieri, N
IR  - Chow J
FIR - Chow, J
IR  - Hui M
FIR - Hui, M
IR  - Shaw D
FIR - Shaw, D
IR  - Lewis N
FIR - Lewis, N
IR  - Okam M
FIR - Okam, M
IR  - Mandell E
FIR - Mandell, E
IR  - Palmer A
FIR - Palmer, A
IR  - Bridges K
FIR - Bridges, K
IR  - Tynan B
FIR - Tynan, B
IR  - Winograd C
FIR - Winograd, C
IR  - Bellevue R
FIR - Bellevue, R
IR  - Dosik H
FIR - Dosik, H
IR  - Sheikhai M
FIR - Sheikhai, M
IR  - Ryans P
FIR - Ryans, P
IR  - Souffrant H
FIR - Souffrant, H
IR  - Adler B
FIR - Adler, B
IR  - Johnson-Telfair A
FIR - Johnson-Telfair, A
IR  - Eskridge L
FIR - Eskridge, L
IR  - Prchal J
FIR - Prchal, J
IR  - Braddock J
FIR - Braddock, J
IR  - McArdle T
FIR - McArdle, T
IR  - Carlos T
FIR - Carlos, T
IR  - Roundtree-Schmotzer A
FIR - Roundtree-Schmotzer, A
IR  - Gardner D
FIR - Gardner, D
EDAT- 2010/06/01 06:00
MHDA- 2010/06/22 06:00
CRDT- 2010/06/01 06:00
PHST- 2010/06/01 06:00 [entrez]
PHST- 2010/06/01 06:00 [pubmed]
PHST- 2010/06/22 06:00 [medline]
AID - 10.1002/ajh.21699 [doi]
PST - ppublish
SO  - Am J Hematol. 2010 Jun;85(6):403-8. doi: 10.1002/ajh.21699.


PMID- 20512893
OWN - NLM
STAT- MEDLINE
DCOM- 20100928
LR  - 20141120
IS  - 1522-2586 (Electronic)
IS  - 1053-1807 (Linking)
VI  - 31
IP  - 6
DP  - 2010 Jun
TI  - Comparison of contrast-enhanced MR angiography to intraarterial digital
      subtraction angiography for evaluation of peripheral arterial occlusive disease: 
      results of a phase III multicenter trial.
PG  - 1402-10
LID - 10.1002/jmri.22086 [doi]
AB  - PURPOSE: To evaluate the efficacy and safety of 0.1 mmol/kg gadodiamide
      administration for contrast-enhanced magnetic resonance angiography (CE-MRA) in
      detecting hemodynamically relevant main stenosis (ie, > or = 50% or occlusion) of
      aortoiliac arteries. MATERIALS AND METHODS: In a multicenter, phase 3, controlled
      study, patients with suspected or proven peripheral arterial occlusive disease
      (PAOD) underwent CE-MRA with administration of gadodiamide. Intraarterial digital
      subtraction angiography (IA-DSA) was used as the reference. The study was
      approved by all Institutional Review Boards or Institutional Ethic Committees
      prior to commencement of patient recruitment and written informed consent was
      obtained from all patients. RESULTS: Independent readers rated 25%-45% of CE-MRA 
      images as excellent compared with 0.3%-6% of noncontrast MRA images. Mean imaging
      acquisition time for CE-MRA was <1 minute (0.7 +/- 1.9 minutes) versus 10 minutes
      (10.8 +/- 3.0) for noncontrast MRA. Sensitivity, specificity, and accuracy of
      CE-MRA were superior compared with those of noncontrast MRA in detecting
      significant arterial stenoses. Compared with IA-DSA, the sensitivity of CE-MRA
      ranged from 80%-88% and the specificity from 73% to 92% for the three blinded
      readers, at the patient level. CONCLUSION: Diagnostic results with CE-MRA were
      superior and more consistent compared with noncontrast MRA for detecting
      hemodynamically relevant main stenoses in patients with suspected or proven PAOD 
      and compared favorably with IA-DSA as a reference standard.
FAU - Bui, Bao T
AU  - Bui BT
AD  - Department of Radiology, Sherbrooke University Hospital Centre, Quebec J1H 5N4,
      Canada. buibao@videotron.ca
FAU - Miller, Stephan
AU  - Miller S
FAU - Mildenberger, Peter
AU  - Mildenberger P
FAU - Sam, Albert 2nd
AU  - Sam A 2nd
FAU - Sheng, Rubin
AU  - Sheng R
CN  - Omniscan MRA Investigator Panel
LA  - eng
PT  - Clinical Trial, Phase III
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
RN  - 0 (Contrast Media)
RN  - 84F6U3J2R6 (gadodiamide)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Angiography, Digital Subtraction/*methods
MH  - Arterial Occlusive Diseases/*diagnosis/pathology
MH  - Contrast Media/*pharmacology
MH  - Electrocardiography/methods
MH  - Female
MH  - Gadolinium DTPA/*pharmacology
MH  - Humans
MH  - Magnetic Resonance Angiography/*methods
MH  - Male
MH  - Middle Aged
MH  - Peripheral Vascular Diseases/*diagnosis/pathology
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
EDAT- 2010/06/01 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/06/01 06:00
PHST- 2010/06/01 06:00 [entrez]
PHST- 2010/06/01 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - 10.1002/jmri.22086 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2010 Jun;31(6):1402-10. doi: 10.1002/jmri.22086.


PMID- 20512425
OWN - NLM
STAT- MEDLINE
DCOM- 20120209
LR  - 20220330
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 17
IP  - 2
DP  - 2011 Jun
TI  - Iranian academia: evolution after revolution and plagiarism as a disorder.
PG  - 213-6
LID - 10.1007/s11948-010-9206-6 [doi]
AB  - Recently, a few of scientific journals raise serious questions about scientific
      ethics and moral judgment of some of the Iranian government's senior executives
      in their papers. Plagiarism, under any circumstances is not justified, and we do 
      not intend to justify it in this note. However, we find it useful in
      understanding why otherwise respected, responsible individuals may engage in
      plagiarism by terse review of the history Iranian academia.
FAU - Ghazinoory, Sepehr
AU  - Ghazinoory S
AD  - Department of Information Technology Management, Tarbiat Modares University,
      Tehran, Iran. Ghazinoory@modares.ac.ir
FAU - Ghazinoori, Soroush
AU  - Ghazinoori S
FAU - Azadegan-Mehr, Mandana
AU  - Azadegan-Mehr M
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100529
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Iran
MH  - Periodicals as Topic/*ethics
MH  - *Plagiarism
MH  - Science/*ethics
MH  - *Scientific Misconduct
EDAT- 2010/06/01 06:00
MHDA- 2012/02/10 06:00
CRDT- 2010/06/01 06:00
PHST- 2010/04/28 00:00 [received]
PHST- 2010/05/11 00:00 [accepted]
PHST- 2010/06/01 06:00 [entrez]
PHST- 2010/06/01 06:00 [pubmed]
PHST- 2012/02/10 06:00 [medline]
AID - 10.1007/s11948-010-9206-6 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2011 Jun;17(2):213-6. doi: 10.1007/s11948-010-9206-6. Epub 2010
      May 29.


PMID- 20512035
OWN - NLM
STAT- MEDLINE
DCOM- 20100817
LR  - 20191210
IS  - 1530-0293 (Electronic)
IS  - 0090-3493 (Linking)
VI  - 38
IP  - 8
DP  - 2010 Aug
TI  - A history of resolving conflicts over end-of-life care in intensive care units in
      the United States.
PG  - 1623-9
LID - 10.1097/CCM.0b013e3181e71530 [doi]
AB  - OBJECTIVES: To present a case of conflict over end-of-life care in the intensive 
      care unit (ICU) and to describe how such conflicts have been resolved in the
      United States since the inception of ICUs. DATA SOURCES: A nonsystematically
      derived sample of published studies and professional and lay commentaries on
      end-of-life care, ethical principles, medical decision-making, medical futility, 
      and especially conflict resolution in the ICU. STUDY SELECTION: Some of those
      studies and commentaries dealing specifically with conflicts over end-of-life
      care in the ICU and their resolution. DATA SYNTHESIS: An historical review of
      conflict resolution over end-of-life issues in U.S. ICUs. RESULTS AND
      CONCLUSIONS: Conflict at the end of life in ICUs in the United States is
      relatively rare because most families and physicians agree about how patients
      should be treated. Nevertheless, conflict still exists over some patients whose
      families insist on care that physicians consider inappropriate and hence
      inadvisable, and over other patients whose families object to care that
      physicians prefer to provide. When such conflict occurs, mediation between
      families and physicians is usually successful in resolving it. Consultation from 
      ethics committees also may be helpful in achieving resolution, and one state
      actually allows such committees to adjudicate disputes. Physicians who act
      unilaterally against family wishes run the risk of malpractice suits, although
      such suits usually are unsuccessful because the physicians are not shown to have 
      violated standards of care.
FAU - Luce, John M
AU  - Luce JM
AD  - Department of Medicine and Anesthesia, University of California, San Francisco,
      and San Francisco General Hospital, San Francisco, CA, USA.
      jluce@medsfgh.ucsf.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Crit Care Med
JT  - Critical care medicine
JID - 0355501
SB  - IM
CIN - Crit Care Med. 2010 Aug;38(8):1742-3. PMID: 20647800
CIN - Crit Care Med. 2011 Jan;39(1):223; author reply 223-4. PMID: 21178551
MH  - Conflict, Psychological
MH  - Critical Care/*ethics/methods/trends
MH  - Decision Making
MH  - Female
MH  - Humans
MH  - Informed Consent/*ethics/legislation & jurisprudence
MH  - Intensive Care Units
MH  - Life Support Care/*ethics
MH  - Male
MH  - Palliative Care/ethics/methods/trends
MH  - Patient Advocacy/*ethics/legislation & jurisprudence
MH  - Resuscitation Orders/legislation & jurisprudence/psychology
MH  - Terminal Care/*ethics/standards/trends
MH  - Treatment Refusal/ethics/legislation & jurisprudence
MH  - United States
RF  - 49
EDAT- 2010/06/01 06:00
MHDA- 2010/08/18 06:00
CRDT- 2010/06/01 06:00
PHST- 2010/06/01 06:00 [entrez]
PHST- 2010/06/01 06:00 [pubmed]
PHST- 2010/08/18 06:00 [medline]
AID - 10.1097/CCM.0b013e3181e71530 [doi]
PST - ppublish
SO  - Crit Care Med. 2010 Aug;38(8):1623-9. doi: 10.1097/CCM.0b013e3181e71530.


PMID- 20511415
OWN - NLM
STAT- MEDLINE
DCOM- 20100922
LR  - 20200930
IS  - 1522-1539 (Electronic)
IS  - 0363-6135 (Linking)
VI  - 299
IP  - 3
DP  - 2010 Sep
TI  - Human thoracic duct in vitro: diameter-tension properties, spontaneous and evoked
      contractile activity.
PG  - H811-8
LID - 10.1152/ajpheart.01089.2009 [doi]
AB  - The current study characterizes the mechanical properties of the human thoracic
      duct and demonstrates a role for adrenoceptors, thromboxane, and endothelin
      receptors in human lymph vessel function. With ethical permission and informed
      consent, portions of the thoracic duct (2-5 cm) were resected and retrieved at
      T(7)-T(9) during esophageal and cardia cancer surgery. Ring segments (2 mm long) 
      were mounted in a myograph for isometric tension (N/m) measurement. The
      diameter-tension relationship was established using ducts from 10 individuals.
      Peak active tension of 6.24 +/- 0.75 N/m was observed with a corresponding
      passive tension of 3.11 +/- 0.67 N/m and average internal diameter of 2.21 mm.
      The equivalent active and passive transmural pressures by LaPlace's law were 47.3
      +/- 4.7 and 20.6 +/- 3.2 mmHg, respectively. Subsequently, pharmacology was
      performed on rings from 15 ducts that were normalized by stretching them until an
      equivalent pressure of 21 mmHg was calculable from the wall tension. At low
      concentrations, norepinephrine, endothelin-1, and the thromboxane-A(2) analog
      U-46619 evoked phasic contractions (analogous to lymphatic pumping), whereas at
      higher contractions they induced tonic activity (maximum tension values of 4.46
      +/- 0.63, 5.90 +/- 1.4, and 6.78 +/- 1.4 N/m, respectively). Spontaneous activity
      was observed in 44% of ducts while 51% of all the segments produced phasic
      contractions after agonist application. Acetylcholine and bradykinin relaxed
      norepinephrine preconstrictions by approximately 20% and approximately 40%,
      respectively. These results demonstrate that the human thoracic duct can develop 
      wall tensions that permit contractility to be maintained across a wide range of
      transmural pressures and that isolated ducts contract in response to important
      vasoactive agents.
FAU - Telinius, Niklas
AU  - Telinius N
AD  - Dept. of Physiology and Biophysics, Aarhus Univ., Ole Worms Alle 4,
      Universitetsparken, DK-8000 Arhus C, Denmark. telinius@me.com
FAU - Drewsen, Nanna
AU  - Drewsen N
FAU - Pilegaard, Hans
AU  - Pilegaard H
FAU - Kold-Petersen, Henrik
AU  - Kold-Petersen H
FAU - de Leval, Marc
AU  - de Leval M
FAU - Aalkjaer, Christian
AU  - Aalkjaer C
FAU - Hjortdal, Vibeke
AU  - Hjortdal V
FAU - Boedtkjer, Donna Briggs
AU  - Boedtkjer DB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100528
PL  - United States
TA  - Am J Physiol Heart Circ Physiol
JT  - American journal of physiology. Heart and circulatory physiology
JID - 100901228
RN  - 0 (Adrenergic alpha-Agonists)
RN  - 0 (Endothelin-1)
RN  - 0 (Receptors, Adrenergic)
RN  - 0 (Vasoconstrictor Agents)
RN  - 0 (Vasodilator Agents)
RN  - 76898-47-0 (15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid)
RN  - N9YNS0M02X (Acetylcholine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid/pharmacology
MH  - Acetylcholine/pharmacology
MH  - Adrenergic alpha-Agonists/pharmacology
MH  - Endothelin-1/pharmacology
MH  - Humans
MH  - Isometric Contraction/drug effects/*physiology
MH  - Myography
MH  - Norepinephrine/pharmacology
MH  - Receptors, Adrenergic/*metabolism
MH  - Thoracic Duct/drug effects/*physiology
MH  - Vasoconstrictor Agents/pharmacology
MH  - Vasodilator Agents/pharmacology
EDAT- 2010/06/01 06:00
MHDA- 2010/09/24 06:00
CRDT- 2010/06/01 06:00
PHST- 2010/06/01 06:00 [entrez]
PHST- 2010/06/01 06:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
AID - ajpheart.01089.2009 [pii]
AID - 10.1152/ajpheart.01089.2009 [doi]
PST - ppublish
SO  - Am J Physiol Heart Circ Physiol. 2010 Sep;299(3):H811-8. doi:
      10.1152/ajpheart.01089.2009. Epub 2010 May 28.


PMID- 20511355
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20100610
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 6
DP  - 2010 Jun
TI  - The ethical professional as endangered person: blog notes on doctor-patient
      relationships.
PG  - 371-4
LID - 10.1136/jme.2009.034900 [doi]
AB  - In theory, physicians subscribe to and in their actions personify a set of
      virtues whose performance demands personal engagement. At the same time, they are
      instructed in their professional roles to remain emotionally and personally
      distant from those they are called to treat. The result, the authors argue, is an
      ethical conflict whose nature is described through an analysis of two narratives 
      drawn from an online blog for young physicians. Confusion over professional
      responsibilities and personal roles were found to affect physicians' perceptions 
      of their clinical duties and their social roles. In addition, it sets in sharp
      relief contemporary debates on physician training and the ethical nature of
      medical professionalism. Practically, the authors suggest, the confusion may
      contribute to early physician burnout. Methodologically, this paper promotes the 
      use of online discussion sites as rich repositories providing an insight into
      real dilemmas and the actual perception of physicians' attempts to address them. 
      It thus promotes use of such sites as a resource in which assumptions about
      physicians' own perceptions about the nature of their role in contemporary
      society can be tested.
FAU - Koch, Tom
AU  - Koch T
AD  - Department of Geography (Medical), University of British Columbia, Vancouver,
      Canada. tomkoch@kochworks.com
FAU - Jones, Sarah
AU  - Jones S
LA  - eng
PT  - Journal Article
DEP - 20100528
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Attitude of Health Personnel
MH  - *Ethics, Professional
MH  - Humans
MH  - Internet
MH  - *Physician's Role
MH  - Physician-Patient Relations/*ethics
MH  - *Professional Competence
EDAT- 2010/06/01 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/06/01 06:00
PHST- 2010/06/01 06:00 [entrez]
PHST- 2010/06/01 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - jme.2009.034900 [pii]
AID - 10.1136/jme.2009.034900 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Jun;36(6):371-4. doi: 10.1136/jme.2009.034900. Epub 2010 May
      28.


PMID- 20511354
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20100610
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 6
DP  - 2010 Jun
TI  - Off-trial access to experimental cancer agents for the terminally ill: balancing 
      the needs of individuals and society.
PG  - 367-70
LID - 10.1136/jme.2009.032466 [doi]
AB  - The development of cancer therapies is a long and arduous process. Because it can
      take several years for a cancer agent to pass clinical testing and be approved
      for use, terminal cancer patients rarely have the time to see these experimental 
      therapies become widely available. For most terminal cancer patients the only
      opportunity they have to access an experimental drug that could potentially
      improve their prognosis is by joining a clinical trial. Unfortunately, several
      aspects of clinical trial methodology that are set in place in order to optimise 
      drug development for the benefit of future generations of cancer patients, pose
      significant limitations to current patient participation. Therefore, several
      terminal cancer patients believe that they should have the right to access
      experimental agents that have passed initial safety testing without having to
      participate in clinical trials. However, granting off-trial access to patients
      could be detrimental to the scientific process of drug development, and thus
      could pose significant risks to the health of future patients relying on sound
      research. Examining this matter through two divergent ethical lenses,
      rights-based ethics and communitarian ethics, may provide new insight into the
      issues surrounding the balance between the autonomous rights of current terminal 
      cancer patients, and the needs of future patients and the values of society.
FAU - Chahal, Manik
AU  - Chahal M
AD  - Department of Oncology, University of Alberta, Cross Cancer Institute, Edmonton
      AB, Canada. manik@ualberta.ca
LA  - eng
PT  - Journal Article
DEP - 20100528
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Drugs, Investigational)
SB  - IM
MH  - Antineoplastic Agents/*therapeutic use
MH  - Drugs, Investigational/*therapeutic use
MH  - *Ethics, Medical
MH  - Health Services Accessibility/ethics
MH  - Humans
MH  - Neoplasms/*drug therapy
MH  - Patient Rights
MH  - Social Values
MH  - Terminal Care/*ethics
MH  - *Terminally Ill
EDAT- 2010/06/01 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/06/01 06:00
PHST- 2010/06/01 06:00 [entrez]
PHST- 2010/06/01 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - jme.2009.032466 [pii]
AID - 10.1136/jme.2009.032466 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Jun;36(6):367-70. doi: 10.1136/jme.2009.032466. Epub 2010 May 
      28.


PMID- 20511352
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20100610
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 6
DP  - 2010 Jun
TI  - Medical decision-making and communication of risks: an ethical perspective.
PG  - 349-52
LID - 10.1136/jme.2009.033282 [doi]
AB  - The medical decision-making process is currently in flux. Decisions are no longer
      made entirely at the physician's discretion: patients are becoming more and more 
      involved in the process. There is a great deal of discussion about the ideal of
      'informed consent', that is that diagnostic and therapeutic decisions should be
      made based on an interaction between physician and patient. This means that
      patients are informed about the advantages and disadvantages of a treatment as
      well as alternatives to the treatment; then, based on this information they can
      decide whether or not they want to undergo the treatment. However, recent studies
      show that the realisation of the ideal of 'shared decision-making' faces a number
      of difficulties related to the fact that patients are not provided with complete 
      and accurate information. Using the example of breast cancer screening, this
      article examines the question of whether, in light of these difficulties, the
      ideal of informed decision-making is only an illusion or whether concrete steps
      can be taken towards the realisation of this ideal.
FAU - Breitsameter, Christof
AU  - Breitsameter C
AD  - Institut fur Moraltheologie, Faculty of Catholic Theology, University of Bochum, 
      Bochum, Germany. christof.breitsameter@rub.de
LA  - eng
PT  - Journal Article
DEP - 20100528
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Communication
MH  - Decision Making/*ethics
MH  - *Ethics, Medical
MH  - Humans
MH  - *Informed Consent
MH  - Mass Screening
MH  - Patient Education as Topic
MH  - Risk
EDAT- 2010/06/01 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/06/01 06:00
PHST- 2010/06/01 06:00 [entrez]
PHST- 2010/06/01 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - jme.2009.033282 [pii]
AID - 10.1136/jme.2009.033282 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Jun;36(6):349-52. doi: 10.1136/jme.2009.033282. Epub 2010 May 
      28.


PMID- 20511239
OWN - NLM
STAT- MEDLINE
DCOM- 20120817
LR  - 20220309
IS  - 1475-3901 (Electronic)
IS  - 1475-3898 (Linking)
VI  - 19
IP  - 4
DP  - 2010 Aug
TI  - Ethics, oversight and quality improvement initiatives.
PG  - 271-4
LID - 10.1136/qshc.2009.038034 [doi]
AB  - BACKGROUND: While substantial public and scholarly attention has focused on the
      ethical review and oversight of quality improvement (QI) initiatives, there are
      no systematic data regarding the institutional mechanisms currently in place to
      review the conduct of QI and the ethical considerations guiding this work.
      METHODS/ANALYSIS: The authors recruited quality improvement practitioners (QIP)
      affiliated with the Institute for Healthcare Improvement (IHI) '100 000 lives'
      campaign to participate in a web-based survey. standard statistical methods were 
      used to analyse the data. RESULTS: Surveys were completed by 132 QIPs (response
      rate=26%). Most respondents indicated that QI initiatives conducted with their
      organisation are subject to review prior to implementation. Respondents strongly 
      agreed that ensuring minimal risk to patients, and privacy and confidentiality
      are relevant ethical considerations for QI initiatives conducted at their
      institution. A majority of respondents also agreed that assessing established
      practices, scientifically sound design, transparency, and the identification and 
      minimisation of potential conflicts are relevant ethical considerations for QI
      initiatives. CONCLUSION: Many QI efforts seem to be getting some oversight, and
      those engaged in the QI initiatives endorse a range of ethical considerations
      that are suited to this work. Yet most of these reviews are not independent of
      those conducting the intervention and are not conducted by people trained in
      ethics. These findings should facilitate the development of a conceptual and
      policy framework that is informed by the realities of QI.
FAU - Taylor, Holly A
AU  - Taylor HA
AD  - Department of Health Policy and Management, Bloomberg School of Public Health and
      Berman Institute of Bioethics, Johns Hopkins University, Hampton House 353, 624
      N, Broadway, Baltimore, MD 21205, USA. htaylor@jhsph.edu
FAU - Pronovost, Peter J
AU  - Pronovost PJ
FAU - Sugarman, Jeremy
AU  - Sugarman J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100527
PL  - England
TA  - Qual Saf Health Care
JT  - Quality & safety in health care
JID - 101136980
MH  - Academies and Institutes
MH  - Administrative Personnel
MH  - Adult
MH  - Confidentiality
MH  - Data Collection
MH  - *Ethics, Professional
MH  - Female
MH  - Focus Groups
MH  - *Government Regulation
MH  - Hospitals
MH  - Humans
MH  - Internet
MH  - Male
MH  - Models, Statistical
MH  - Organizational Policy
MH  - Quality Assurance, Health Care/*ethics/standards
MH  - Quality Improvement/*ethics/standards
MH  - Risk Management
MH  - Safety Management
MH  - United States
EDAT- 2010/06/01 06:00
MHDA- 2012/08/18 06:00
CRDT- 2010/06/01 06:00
PHST- 2010/06/01 06:00 [entrez]
PHST- 2010/06/01 06:00 [pubmed]
PHST- 2012/08/18 06:00 [medline]
AID - qshc.2009.038034 [pii]
AID - 10.1136/qshc.2009.038034 [doi]
PST - ppublish
SO  - Qual Saf Health Care. 2010 Aug;19(4):271-4. doi: 10.1136/qshc.2009.038034. Epub
      2010 May 27.


PMID- 20510488
OWN - NLM
STAT- MEDLINE
DCOM- 20110421
LR  - 20191210
IS  - 1532-2793 (Electronic)
IS  - 0260-6917 (Linking)
VI  - 31
IP  - 1
DP  - 2011 Jan
TI  - Nursing students' experiences of being a research participant: Findings from a
      longitudinal study.
PG  - 107-11
LID - 10.1016/j.nedt.2010.04.006 [doi]
AB  - AIM: the paper reports on a study that highlighted the benefits to nursing
      students of taking part in research. BACKGROUND: there is a great deal of
      literature and ethical guidance to protect research participants who take part in
      research. However, there is limited empirical evidence regarding the beneficial
      outcomes of research participation. METHODS: the findings reported in this paper 
      were part of a qualitative, longitudinal study undertaken in the UK between 2007 
      and 2009. The study explored the empowerment of nursing students in clinical
      practice. Thirteen undergraduate nursing students were recruited to the study.
      Data generation was in the form of annual, individual interviews. Over the course
      of the study, students were asked about their experiences of participating in the
      research. FINDINGS: Nursing students reported significant benefits as a result of
      research participation. These were threefold: strengthening self; strengthening
      knowledge; and strengthening clinical practice. Protection of research
      participants is crucial, but emphasis on protection obscures the potential
      benefits that result from being a research participant. CONCLUSIONS: researchers 
      who recruit nursing students to educational research must protect them from harm.
      However, in the process of weighing up risks associated with their educational
      research, they need to be cognizant of potential benefits that can arise for
      nursing students when they are asked to participate in nursing research.
CI  - 2010 Elsevier Ltd. All rights reserved.
FAU - Bradbury-Jones, Caroline
AU  - Bradbury-Jones C
AD  - University of Dundee, School of Nursing and Midwifery, 11 Airlie Place, Dundee,
      DD1 4HJ, United Kingdom. c.bradburyjones@dundee.ac.uk
FAU - Stewart, Sheila
AU  - Stewart S
FAU - Irvine, Fiona
AU  - Irvine F
FAU - Sambrook, Sally
AU  - Sambrook S
LA  - eng
PT  - Journal Article
DEP - 20100526
PL  - Scotland
TA  - Nurse Educ Today
JT  - Nurse education today
JID - 8511379
MH  - *Attitude of Health Personnel
MH  - Education, Nursing, Baccalaureate/methods/statistics & numerical data
MH  - Faculty, Nursing
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Interview, Psychological
MH  - Longitudinal Studies
MH  - Nursing Research/methods/statistics & numerical data
MH  - *Patient Selection
MH  - *Power, Psychological
MH  - Qualitative Research
MH  - Research Personnel/*psychology/statistics & numerical data
MH  - Students, Nursing/*psychology/statistics & numerical data
EDAT- 2010/06/01 06:00
MHDA- 2011/04/22 06:00
CRDT- 2010/06/01 06:00
PHST- 2009/12/02 00:00 [received]
PHST- 2010/03/31 00:00 [revised]
PHST- 2010/04/23 00:00 [accepted]
PHST- 2010/06/01 06:00 [entrez]
PHST- 2010/06/01 06:00 [pubmed]
PHST- 2011/04/22 06:00 [medline]
AID - S0260-6917(10)00082-1 [pii]
AID - 10.1016/j.nedt.2010.04.006 [doi]
PST - ppublish
SO  - Nurse Educ Today. 2011 Jan;31(1):107-11. doi: 10.1016/j.nedt.2010.04.006. Epub
      2010 May 26.


PMID- 20510225
OWN - NLM
STAT- MEDLINE
DCOM- 20101122
LR  - 20120710
IS  - 1090-2392 (Electronic)
IS  - 0011-2240 (Linking)
VI  - 61
IP  - 1
DP  - 2010 Aug
TI  - Bovine oocyte vitrification using the Cryotop method: effect of cumulus cells and
      vitrification protocol on survival and subsequent development.
PG  - 66-72
LID - 10.1016/j.cryobiol.2010.05.002 [doi]
AB  - The ability to successfully cryopreserve mammalian oocytes has numerous
      practical, economical and ethical benefits, which may positively impact animal
      breeding programs and assisted conception in humans. However, oocyte survival and
      development following vitrification remains poor. The aim of the present study
      was (1) to evaluate the effect of the presence of cumulus cells on the outcome of
      vitrification of immature (GV) or mature (MII) bovine oocytes, (2) to compare
      empirical and theoretical vitrification protocols, and (3) to assess the effect
      of adding ice blockers to vitrification media on survival and development
      competence of bovine oocytes following vitrification using the Cryotop method. In
      Experiment 1, cumulus-enclosed and partially-denuded GV and MII oocytes were
      vitrified in 15% EG+15% Me(2)SO+0.5M sucrose in two steps. In Experiment 2, GV
      oocytes were vitrified either as above or using theoretical modeling based on
      permeability and osmotic tolerance characteristics in 30% EG+11.4% trehalose in
      three steps or 40% EG+11.4% trehalose in four steps. In Experiment 3, GV oocytes 
      were vitrified in media supplemented or not with 1 of 2 ice blockers (21st
      Century Medicine, Fontana, CA) 1% X-1000, 1% Z-1000 or both in three steps. In
      Experiment 1, the survival, cleavage and blastocyst rate of cumulus-enclosed
      oocytes was significantly higher than those of partially-denuded oocytes when
      vitrified at the GV stage (93.8% vs. 81.3%, 65.8% vs. 47.3%, 11.3% vs. 4.0%,
      respectively, P<0.05). However, no significant effect of cumulus cover was
      detected between the two groups when vitrified at MII (93.0% vs. 91.8%, 35.2% vs.
      36.8%, 5.0% vs. 4.4%, respectively). Furthermore, cumulus-enclosed oocytes
      vitrified at the GV stage exhibited significantly higher developmental competence
      than those vitrified at the MII stage (P<0.05). In Experiment 2, there were no
      significant differences in the survival, cleavage and blastocyst rate among three
      protocols (86.0% vs. 92.8% vs. 91.2%, 44.8% vs. 54.4% vs. 45.6%, 5.0% vs. 5.4%
      vs. 4.0%, respectively). However, cleavage and blastocyst rate were significantly
      lower (P<0.05) than non-vitrified control oocytes. In Experiment 3, the presence 
      of ice blockers did not alter the cleavage rate or blastocyst development
      (P>0.05). In conclusion, cumulus-enclosed GV bovine oocytes survived
      vitrification and subsequently developed at higher rates than MII oocytes using
      Cryotop method and conventional IVF procedure. Theoretical analysis of
      permeability characteristics and tolerance limits could not explain the low
      developmental competence of vitrified oocytes.
CI  - (c) 2010 Elsevier Inc. All rights reserved.
FAU - Zhou, X L
AU  - Zhou XL
AD  - School of Agriculture, Food Science and Veterinary Medicine, University College
      Dublin, Belfield, Dublin 4, Ireland.
FAU - Al Naib, A
AU  - Al Naib A
FAU - Sun, Da-Wen
AU  - Sun DW
FAU - Lonergan, P
AU  - Lonergan P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100525
PL  - Netherlands
TA  - Cryobiology
JT  - Cryobiology
JID - 0006252
RN  - 0 (Cryoprotective Agents)
SB  - IM
EIN - Cryobiology. 2012 Jun;64(3):306. Sun, D W [corrected to Sun, Da-Wen]
MH  - Animals
MH  - Cattle
MH  - Cell Survival/drug effects
MH  - Cryopreservation/*methods
MH  - Cryoprotective Agents/*pharmacology
MH  - *Cumulus Cells
MH  - Female
MH  - Fertilization in Vitro/methods
MH  - Models, Theoretical
MH  - Oocytes/*drug effects
EDAT- 2010/06/01 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/06/01 06:00
PHST- 2010/01/27 00:00 [received]
PHST- 2010/05/05 00:00 [revised]
PHST- 2010/05/10 00:00 [accepted]
PHST- 2010/06/01 06:00 [entrez]
PHST- 2010/06/01 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S0011-2240(10)00084-2 [pii]
AID - 10.1016/j.cryobiol.2010.05.002 [doi]
PST - ppublish
SO  - Cryobiology. 2010 Aug;61(1):66-72. doi: 10.1016/j.cryobiol.2010.05.002. Epub 2010
      May 25.


PMID- 20510154
OWN - NLM
STAT- MEDLINE
DCOM- 20100811
LR  - 20100531
IS  - 0767-0974 (Print)
IS  - 0767-0974 (Linking)
VI  - 26
IP  - 5
DP  - 2010 May
TI  - [Requiem for Henrietta].
PG  - 529-33
LID - 10.1051/medsci/2010265529 [doi]
AB  - Fifty years after Henrietta Lacks died of aggressive glandular cervical cancer,
      the first cell line - HeLa cell line - is the workhorse of laboratories
      everywhere. It helped to produce drugs for numerous diseases, including
      poliomyelitis, Parkinson's, leukemias. But they are so outrageously robust that
      they contaminated hundred of other cell lines, as far away as Russia. For
      decades, biologists worked with contaminated cell lines and today, the problem is
      not yet solved. But the story of HeLa cells is also a moving reflection of racial
      and ethical issues in medicine in the late half-twentieth century in the USA.
FAU - Gilgenkrantz, Simone
AU  - Gilgenkrantz S
AD  - simsimone.gilgenkrantz@gmail.com
LA  - fre
PT  - Biography
PT  - English Abstract
PT  - Historical Article
PT  - Journal Article
TT  - Requiem pour Henrietta.
PL  - France
TA  - Med Sci (Paris)
JT  - Medecine sciences : M/S
JID - 8710980
SB  - IM
MH  - Adenocarcinoma/history/pathology
MH  - Artifacts
MH  - Baltimore
MH  - Cell Biology/*history
MH  - Cell Culture Techniques/ethics/*history/standards
MH  - Cell Line
MH  - Family
MH  - Female
MH  - *HeLa Cells/transplantation
MH  - History, 20th Century
MH  - Human Experimentation/ethics/history
MH  - Humans
MH  - Informed Consent/legislation & jurisprudence
MH  - Journalism, Medical
MH  - Medical Oncology/*history
MH  - Patient Rights/history/legislation & jurisprudence
MH  - Tissue Banks
MH  - Tissue and Organ Harvesting/legislation & jurisprudence
MH  - Uterine Cervical Neoplasms/history/pathology
MH  - Young Adult
PS  - Lacks H
FPS - Lacks, Henrietta
PS  - Gey GO
FPS - Gey, George Otto
EDAT- 2010/06/01 06:00
MHDA- 2010/08/12 06:00
CRDT- 2010/06/01 06:00
PHST- 2010/06/01 06:00 [entrez]
PHST- 2010/06/01 06:00 [pubmed]
PHST- 2010/08/12 06:00 [medline]
AID - 00/00/0F/74/ [pii]
AID - 10.1051/medsci/2010265529 [doi]
PST - ppublish
SO  - Med Sci (Paris). 2010 May;26(5):529-33. doi: 10.1051/medsci/2010265529.


PMID- 20510152
OWN - NLM
STAT- MEDLINE
DCOM- 20100811
LR  - 20100531
IS  - 0767-0974 (Print)
IS  - 0767-0974 (Linking)
VI  - 26
IP  - 5
DP  - 2010 May
TI  - [Living donors for kidney transplantation: ethical and legal challenges].
PG  - 522-5
LID - 10.1051/medsci/2010265522 [doi]
AB  - Living donor kidney transplantation has developed very heterogeneously worldwide 
      despite excellent results and without taking into account the context of global
      organ shortage. Such a heterogeneity highlights persistent ethical issues,
      whereas organ trafficking is emerging as an organized transplant tourism
      reinforcing the need for strong national legal frameworks. Despite its powerful
      regulation system, which ensures standardization, transparency and accountability
      of support for donation, France remains reluctant to enlarge the circle of legal 
      donors, whereas it would be the first step to give a greater role to living organ
      donation.
FAU - Mamzer-Bruneel, Marie-France
AU  - Mamzer-Bruneel MF
AD  - Service de transplantation renale, Laboratoire d'ethique medicale et de medecine 
      legale de l'universite Paris Descartes, Hopital Necker, rue de Sevres, Paris,
      France.
FAU - Fournier, Catherine
AU  - Fournier C
FAU - Legendre, Christophe
AU  - Legendre C
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - La transplantation renale a partir de donneurs vivants: enjeux ethiques et
      juridiques.
PL  - France
TA  - Med Sci (Paris)
JT  - Medecine sciences : M/S
JID - 8710980
SB  - IM
MH  - Adult
MH  - Europe
MH  - France
MH  - Humans
MH  - Kidney Transplantation/economics/*ethics/*legislation & jurisprudence/statistics 
      & numerical data
MH  - Living Donors/*ethics/*legislation & jurisprudence/supply & distribution
MH  - Nephrectomy/adverse effects
MH  - Risk
MH  - Tissue and Organ Harvesting/adverse effects
MH  - Tissue and Organ Procurement/economics/*ethics/*legislation & jurisprudence
MH  - United States
RF  - 23
EDAT- 2010/06/01 06:00
MHDA- 2010/08/12 06:00
CRDT- 2010/06/01 06:00
PHST- 2010/06/01 06:00 [entrez]
PHST- 2010/06/01 06:00 [pubmed]
PHST- 2010/08/12 06:00 [medline]
AID - 00/00/0F/71/ [pii]
AID - 10.1051/medsci/2010265522 [doi]
PST - ppublish
SO  - Med Sci (Paris). 2010 May;26(5):522-5. doi: 10.1051/medsci/2010265522.


PMID- 20509807
OWN - NLM
STAT- MEDLINE
DCOM- 20100916
LR  - 20120302
IS  - 1037-6178 (Print)
IS  - 1037-6178 (Linking)
VI  - 34
IP  - 2
DP  - 2010 Feb-Mar
TI  - Informed consent for research involving people with dementia: a grey area.
PG  - 230-6
LID - 10.5172/conu.2010.34.2.230 [doi]
AB  - Research involving people with dementia has been flagged as a key priority by
      Alzheimer's International. Dementia has been an Australian National Health
      Priority since 2005, yet there are no clear guidelines for seeking and obtaining 
      informed consent from people with dementia to participate in observational
      research. Informed consent is an ethical requirement for the conduct of research 
      involving humans. Although many people with dementia are able to express a desire
      to be involved in research, the insidious progression of the disease reduces a
      person's ability to understand and appreciate the consequences of involvement.
      This paper explores the author's journey of seeking and obtaining informed
      consent for a mixed methods study which involved the observation of older people 
      with dementia.
FAU - Cubit, Katrina
AU  - Cubit K
AD  - School of Nursing & Midwifery, University of Tasmania, Launceston, TAS,
      Australia.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Contemp Nurse
JT  - Contemporary nurse
JID - 9211867
MH  - Aggression/psychology
MH  - Australia
MH  - *Dementia/psychology
MH  - Ethics Committees, Research
MH  - Guidelines as Topic
MH  - Humans
MH  - Informed Consent/*ethics/legislation & jurisprudence/psychology
MH  - *Mental Competency/legislation & jurisprudence/psychology
MH  - Nontherapeutic Human Experimentation/ethics/legislation & jurisprudence
MH  - Nursing Homes
MH  - *Nursing Research/ethics/organization & administration
MH  - Patient Selection/ethics
MH  - Research Design
MH  - Research Subjects/legislation & jurisprudence/psychology
MH  - Tasmania
EDAT- 2010/06/01 06:00
MHDA- 2010/09/18 06:00
CRDT- 2010/06/01 06:00
PHST- 2010/06/01 06:00 [entrez]
PHST- 2010/06/01 06:00 [pubmed]
PHST- 2010/09/18 06:00 [medline]
AID - 10.5172/conu.2010.34.2.230 [doi]
AID - 10.5172/conu.2010.34.2.230 [pii]
PST - ppublish
SO  - Contemp Nurse. 2010 Feb-Mar;34(2):230-6. doi: 10.5172/conu.2010.34.2.230.


PMID- 20509593
OWN - NLM
STAT- MEDLINE
DCOM- 20110301
LR  - 20220310
IS  - 1940-4921 (Print)
IS  - 1938-2464 (Linking)
VI  - 4
IP  - 1
DP  - 2011 Jan
TI  - Responding to poor-quality care during research in nursing homes.
PG  - 47-52
LID - 10.3928/19404921-20100504-04 [doi]
AB  - For nurse researchers, responding appropriately to resident abuse is
      straightforward: The abuse must be reported. However, responding to care that is 
      of poor quality-where care practices are problematic but do not meet the
      definition of reportable abuse-is not so straightforward. Decision making may be 
      influenced by ethical and professional principles, as well as self-interest to
      complete a research project. The purpose of this article is to provoke a dialogue
      about a dilemma faced by many researchers conducting research in long-term care: 
      responding to poor-quality care that does not meet the state's definition of
      resident abuse. We will accomplish this by providing a real-life situation faced 
      by a novice researcher conducting her first funded research project, identifying 
      some of the important considerations and possible responses by nurse researchers.
      Optimally, nurse researchers will develop a plan for responding to poor care
      before beginning the study.
CI  - Copyright 2011, SLACK Incorporated.
FAU - Krause, Melanie R
AU  - Krause MR
AD  - University of Wisconsin-Madison, School of Nursing, Clinical Science Center,
      Madison, WI 53711, USA. mrkrause@wisc.edu
FAU - Palmer, Janice L
AU  - Palmer JL
FAU - Bowers, Barbara J
AU  - Bowers BJ
FAU - Buckwalter, Kathleen C
AU  - Buckwalter KC
LA  - eng
GR  - F31 NR010039/NR/NINR NIH HHS/United States
GR  - F31 NR010039-02/NR/NINR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100528
PL  - United States
TA  - Res Gerontol Nurs
JT  - Research in gerontological nursing
JID - 101392499
SB  - IM
MH  - *Health Services Research
MH  - Long-Term Care
MH  - *Nursing Homes
MH  - *Quality of Health Care
PMC - PMC2932828
MID - NIHMS201201
EDAT- 2010/06/01 06:00
MHDA- 2011/03/02 06:00
CRDT- 2010/06/01 06:00
PHST- 2009/03/22 00:00 [received]
PHST- 2009/10/29 00:00 [accepted]
PHST- 2010/06/01 06:00 [entrez]
PHST- 2010/06/01 06:00 [pubmed]
PHST- 2011/03/02 06:00 [medline]
AID - 10.3928/19404921-20100504-04 [doi]
PST - ppublish
SO  - Res Gerontol Nurs. 2011 Jan;4(1):47-52. doi: 10.3928/19404921-20100504-04. Epub
      2010 May 28.


PMID- 20509587
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20101108
IS  - 0148-4834 (Print)
IS  - 0148-4834 (Linking)
VI  - 49
IP  - 11
DP  - 2010 Nov
TI  - Faculty perceptions of student documentation skills during the transition from
      paper-based to electronic health records systems.
PG  - 615-21
LID - 10.3928/01484834-20100524-06 [doi]
AB  - Nursing faculty perceptions of teaching undergraduate nursing students
      documentation skills using either paper-based or electronic health record systems
      were explored in this study. Twenty-five nursing faculty in a large urban public 
      school of nursing were interviewed using a 13-item survey questionnaire.
      Responses were analyzed using the constant comparative method, and four major
      themes arose: teaching strategies; learning from experts; road from novice to
      expert; and legal, ethical, and institutional issues. Results demonstrate how
      faculty overcome myriad obstacles encountered while teaching clinical
      documentation processes. Self-efficacy theory, with its emphasis on knowledge,
      skills, and social context, describes how faculty are modeling behaviors
      necessary to succeed during this transition from paper to electronic
      documentation. The school of nursing is integrating the findings from this
      research to further informatics integration across the curricula, and ongoing
      research is planned to investigate issues of self-efficacy and student and
      clinical staff perceptions of teaching-learning clinical documentation.
CI  - Copyright 2010, SLACK Incorporated.
FAU - Mahon, Pamela Young
AU  - Mahon PY
AD  - Hunter Bellevue School of Nursing, City University of New York, New York, NY,
      USA. pmahon@hunter.cuny.edu
FAU - Nickitas, Donna M
AU  - Nickitas DM
FAU - Nokes, Kathleen M
AU  - Nokes KM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100528
PL  - United States
TA  - J Nurs Educ
JT  - The Journal of nursing education
JID - 7705432
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Attitude to Computers
MH  - Clinical Competence/*standards
MH  - Computer User Training/methods
MH  - Curriculum
MH  - Documentation/*standards
MH  - Education, Nursing, Baccalaureate/organization & administration
MH  - Electronic Health Records/*organization & administration
MH  - *Faculty, Nursing/statistics & numerical data
MH  - Humans
MH  - Models, Educational
MH  - Models, Nursing
MH  - Models, Psychological
MH  - New York City
MH  - Nursing Informatics/education
MH  - Nursing Methodology Research
MH  - Nursing Records/standards
MH  - Organizational Innovation
MH  - Qualitative Research
MH  - Self Efficacy
MH  - *Students, Nursing/psychology
EDAT- 2010/06/01 06:00
MHDA- 2011/01/07 06:00
CRDT- 2010/06/01 06:00
PHST- 2009/03/18 00:00 [received]
PHST- 2009/12/21 00:00 [accepted]
PHST- 2010/06/01 06:00 [entrez]
PHST- 2010/06/01 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
AID - 10.3928/01484834-20100524-06 [doi]
PST - ppublish
SO  - J Nurs Educ. 2010 Nov;49(11):615-21. doi: 10.3928/01484834-20100524-06. Epub 2010
      May 28.


PMID- 27683357
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160929
LR  - 20201001
IS  - 1650-3414 (Print)
IS  - 1650-3414 (Linking)
VI  - 21
IP  - 2
DP  - 2010 Jun
TI  - Laboratory Medicine Specialization Teaching and Training in Italy with a Glance
      to Some European and Non-European Countries.
PG  - 33-9
AB  - UNLABELLED: The Italian Ministry of Education, University and Research has
      recently reformed the medical schools of specialization in accordance with a
      series of EC Directives. Four different curricula have been defined into the
      class of "Diagnostics and Laboratory Medicine", respectively: Anatomic Pathology,
      Clinical Biochemistry, Clinical Pathology, and Microbiology & Virology. Each
      curriculum is based on a scheme of 300 credits, that includes formal educational 
      activities) and practical activities distributed on a five years' period. The
      four curricula share a common course of either formal or practical activities.
      Main training and professional objectives are in favour of: a) the principles of 
      appropriateness and of evidence based medicine, b) the acquisition of either
      on-the-bench experience and practice, or skills in organizing and managing the
      laboratory activities and personnel c) the understanding of data and phenomena
      relevant to the patients in a clinically oriented vision, d) the ability to
      translate research results into diagnostic advantages, e) the values of humanism 
      and ethics. When comparing the Italian curriculum with some European and
      non-European curricula in Laboratory Medicine, many similarities are apparent:
      above all, the medical pertinence of the profession is increasingly affirmed in
      favour of a consultancy role to be played by the specialist in Laboratory
      Medicine at the clinical level. MAIN CONCLUSIONS: a) the education, skill and
      expertise required for laboratory specialists regard now a broad variety of
      issues, b) these embrace not only technical, scientific and organizational
      aspects, but even the ability to develop consultative capacities in different
      diagnostic areas, c) moreover the implicit translational aspects in the
      profession require the adoption of innovative and multifaceted curricula.
FAU - Guidi, Gian Cesare
AU  - Guidi GC
LA  - eng
PT  - Journal Article
DEP - 20100609
PL  - Italy
TA  - EJIFCC
JT  - EJIFCC
JID - 101092742
PMC - PMC4975331
EDAT- 2010/06/01 00:00
MHDA- 2010/06/01 00:01
CRDT- 2016/09/30 06:00
PHST- 2016/09/30 06:00 [entrez]
PHST- 2010/06/01 00:00 [pubmed]
PHST- 2010/06/01 00:01 [medline]
PST - epublish
SO  - EJIFCC. 2010 Jun 9;21(2):33-9. eCollection 2010 Jun.


PMID- 26760012
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160115
LR  - 20160114
IS  - 1679-4508 (Print)
IS  - 1679-4508 (Linking)
VI  - 8
IP  - 2
DP  - 2010 Jun
TI  - The need to include obstetric nurses in prenatal care visits in the public health
      system.
PG  - 241-7
LID - 10.1590/S1679-45082010RW1486 [doi]
LID - S1679-45082010000200241 [pii]
AB  - OBJECTIVE: To investigate, with a qualitative approach, the role of Obstetric
      Nurses at the primary level of care given to women's health as a vital component 
      of the multidisciplinary team, which today is fundamental for providing care,
      prevention as well as health education and promotion, especially in programs
      whose activities are geared towards primary care of pregnant, parturient, and
      puerpera women. METHODS: Brazilian laws and the determinations of Nursing
      Councils in reference to the activities of the obstetric nurse were researched,
      including the nurse's responsibilities and limits. The bibliographic search was
      conducted in health-related journals, lay publications, and the Internet.
      RESULTS: The conflicts between professional physicians and nurses were discussed.
      CONCLUSIONS: It was concluded that the activities of the nurse, conducting
      low-risk prenatal clinical visits in the basic healthcare network, has legal and 
      ethical support and provides true benefit to the clients.
FAU - Garcia, Selma Aparecida Lagrosa
AU  - Garcia SA
AD  - Instituto de Assistencia Medica ao Servidor Publico Estadual - IAMSPE, Sao Paulo,
      SP, BR.
FAU - Garcia, Sidney Antonio Lagrosa
AU  - Garcia SA
AD  - Hospital do Servidor Publico Estadual "Francisco Morato de Oliveira" - HSPE-FMO, 
      Sao Paulo, SP, BR.
FAU - Lippi, Umberto Gazi
AU  - Lippi UG
AD  - Hospital do Servidor Publico Estadual "Francisco Morato de Oliveira" - HSPE-FMO, 
      Sao Paulo, SP, BR.
LA  - eng
LA  - por
PT  - Journal Article
PL  - Brazil
TA  - Einstein (Sao Paulo)
JT  - Einstein (Sao Paulo, Brazil)
JID - 101281800
EDAT- 2010/06/01 00:00
MHDA- 2010/06/01 00:01
CRDT- 2016/01/14 06:00
PHST- 2009/09/03 00:00 [received]
PHST- 2010/04/12 00:00 [accepted]
PHST- 2016/01/14 06:00 [entrez]
PHST- 2010/06/01 00:00 [pubmed]
PHST- 2010/06/01 00:01 [medline]
AID - S1679-45082010000200241 [pii]
AID - 10.1590/S1679-45082010RW1486 [doi]
PST - ppublish
SO  - Einstein (Sao Paulo). 2010 Jun;8(2):241-7. doi: 10.1590/S1679-45082010RW1486.


PMID- 26760008
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160115
LR  - 20160114
IS  - 1679-4508 (Print)
IS  - 1679-4508 (Linking)
VI  - 8
IP  - 2
DP  - 2010 Jun
TI  - Humanization according to cancer patients with extended hospitalization periods.
PG  - 221-7
LID - 10.1590/S1679-45082010AO1369 [doi]
LID - S1679-45082010000200221 [pii]
AB  - OBJECTIVE: To identify the concept of humanization and raise aspects that
      contribute towards and that hinder humanization of hospital care, according to
      the opinion of oncology patients. METHODS: This is a descriptive-exploratory
      survey, with a qualitative-quantitative approach. The sample was made up of 10
      patients hospitalized for more than 30 days at the Oncology Unit of Hospital
      Israelita Albert Einstein, who, after satisfying ethical and legal procedures,
      were interviewed and answered three questions in reference to humanization in
      oncology. RESULTS: The factors that contributed more towards humanization were
      warmth in giving care, friendliness, and smiles, and the factors that hindered it
      were bad moods, noise, and not being promptly attended. CONCLUSIONS: Hospital
      humanization should be experienced and felt by all those who work at hospital and
      needs to be reflected in the care offered to the client and his/her family
      members. These aspects become vital in oncology in order to understand the
      difficult period the patient is going through during the hospital stay, showing
      an interest in his/her problems and struggles with an attitude of empathy and
      cordiality, always acting ethically and with professional responsibility.
FAU - Brito, Natalia Tatiani Goncalves
AU  - Brito NT
AD  - Hospital Israelita Albert Einstein - HIAE, Sao Paulo, SP, BR.
FAU - Carvalho, Rachel de
AU  - Carvalho Rd
AD  - Faculdade de Enfermagem, Hospital Israelita Albert Einstein - HIAE, Sao Paulo,
      SP, BR.
LA  - eng
LA  - por
PT  - Journal Article
PL  - Brazil
TA  - Einstein (Sao Paulo)
JT  - Einstein (Sao Paulo, Brazil)
JID - 101281800
EDAT- 2010/06/01 00:00
MHDA- 2010/06/01 00:01
CRDT- 2016/01/14 06:00
PHST- 2009/06/09 00:00 [received]
PHST- 2010/04/12 00:00 [accepted]
PHST- 2016/01/14 06:00 [entrez]
PHST- 2010/06/01 00:00 [pubmed]
PHST- 2010/06/01 00:01 [medline]
AID - S1679-45082010000200221 [pii]
AID - 10.1590/S1679-45082010AO1369 [doi]
PST - ppublish
SO  - Einstein (Sao Paulo). 2010 Jun;8(2):221-7. doi: 10.1590/S1679-45082010AO1369.


PMID- 25813810
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150328
LR  - 20150327
IS  - 2005-727X (Print)
IS  - 2005-727X (Linking)
VI  - 22
IP  - 2
DP  - 2010 Jun
TI  - Analysis of Medical School Alumni's Perception on the Importance and Educational 
      Needs of Outcomes.
PG  - 113-20
LID - 10.3946/kjme.2010.22.2.113 [doi]
AB  - PURPOSE: This study examined how important graduates consider the 15 items of
      educational outcomes (importance) and how much they feel that they have achieved 
      at graduation (accomplishment), determined whether outcomes varied according to
      profession, and assessed what graduates' educational needs are. METHODS: A
      questionnaire was given to 85 graduates of Ajou University School of Medicine.
      The data were analyzed by Kruskal-Wallis test using SPSS 12.0. The Borich formula
      was used to examine graduates' educational needs. RESULTS: Educational outcomes, 
      such as medical knowledge and clinical skills at the basic medical levels,
      communication skills, and social accountabilities, were considered important in
      every profession. The Kruskal-Wallis test results demonstrated that the 15 items 
      of educational outcomes were not significantly different between careers
      (p>0.05), but the average scores were. Doctors in private practice placed an
      emphasis on keeping a healthy body and mind and continuing lifelong learning;
      doctors in general hospitals emphasized understanding the health care industry's 
      policies; and professors at university hospitals focused on proper medical
      ethics-the house staff emphasized teamwork with colleagues. CONCLUSION: These
      test results can be used as basic materials for reflecting on educational
      objectives, student performance, and revision of the curricula. Further studies
      on how to measure educational outcomes are necessary.
FAU - Chae, Su-Jin
AU  - Chae SJ
AD  - Brain Korea 21 Project, Ajou University School of Medicine, Suwon, Korea.
LA  - eng
PT  - Journal Article
DEP - 20100630
PL  - Korea (South)
TA  - Korean J Med Educ
JT  - Korean journal of medical education
JID - 101503071
OTO - NOTNLM
OT  - Competence
OT  - Educational needs
OT  - Outcome
OT  - Outcome-based education
EDAT- 2010/06/01 00:00
MHDA- 2010/06/01 00:01
CRDT- 2015/03/28 06:00
PHST- 2010/02/23 00:00 [received]
PHST- 2010/05/10 00:00 [accepted]
PHST- 2015/03/28 06:00 [entrez]
PHST- 2010/06/01 00:00 [pubmed]
PHST- 2010/06/01 00:01 [medline]
AID - kjme.2010.22.2.113 [pii]
AID - 10.3946/kjme.2010.22.2.113 [doi]
PST - ppublish
SO  - Korean J Med Educ. 2010 Jun;22(2):113-20. doi: 10.3946/kjme.2010.22.2.113. Epub
      2010 Jun 30.


PMID- 25303758
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151026
LR  - 20220310
IS  - 0103-507X (Print)
IS  - 0103-507X (Linking)
VI  - 22
IP  - 2
DP  - 2010 Jun
TI  - Spontaneous breathing trial evaluation in preterm newborns extubation.
PG  - 159-65
LID - S0103-507X2010000200010 [pii]
AB  - OBJECTIVE: Neonates mechanic ventilation weaning has become a major clinical
      challenge, and constitutes a large portion of neonatal intensive care units
      workload. The spontaneous breathing trial (SBT), performed immediately before
      extubation, can provide useful information on the patient's spontaneous breathing
      ability. This study aimed to assess the SBT effectiveness for extubation success 
      prediction in mechanically ventilated preterm infants. METHODS: After Ethics
      Committee approval, an observational, longitudinal, prospective study was
      conducted. A sample of 60 preterm infants compliant with the weaning criteria was
      categorized in two groups: 'SBT' group (n=30), with the patients who underwent 30
      minutes spontaneous breathing trial (SBT) with continuous positive pressure
      airway (CPAP), and the control group (n=30) where the extubation was performed
      without spontaneous breathing trial. The heart rate (HR), respiratory rate (RR), 
      pulse oxymetry oxygen saturation (SpO2) and the Silverman-Andersen score were
      recorded before and 10, 20 and 30 minutes after the spontaneous breathing trial. 
      Were also assessed for both groups, and versus extubation success or failure, the
      weight, gestational age, Apgar score, mean airway pressure, inspired oxygen
      concentration, and tracheal tube time. The Chi-square test was used for
      categorical variables and the Mann-Whitney test for non-normal distribution.
      Extubation success was defined as a 48 hours period with no reintubation
      requirement. RESULTS: No significant differences were identified between the
      groups for the analyzed variables, except for the mean airway pressure. A
      significant association was shown between spontaneous breathing trial and
      successful extubation. CONCLUSION: The significant association between SBT and
      extubation success may contribute for prediction of successful weaning in preterm
      infants.
FAU - Andrade, Livia Barboza
AU  - Andrade LB
AD  - Instituto de Medicina Integral Prof. Fernando Figueira, Recife, PE, Brasil.
FAU - Melo, Thais Myrian Aragao
AU  - Melo TM
AD  - Universidade Federal de Pernambuco, Recife, PE, Brasil.
FAU - Morais, Danielle Ferreira do Nascimento
AU  - Morais DF
AD  - Instituto de Medicina Integral Prof. Fernando Figueira, Recife, PE, Brasil.
FAU - Lima, Marcela Raquel Oliveira
AU  - Lima MR
AD  - Universidade Federal de Pernambuco, Recife, PE, Brasil.
FAU - Albuquerque, Emidio Cavalcanti
AU  - Albuquerque EC
AD  - Centro de Pesquisas Aggeu Magalhaes, Recife, PE, Brasil.
FAU - Martimiano, Paula Honorio de Melo
AU  - Martimiano PH
AD  - Universidade Federal de Pernambuco, Recife, PE, Brasil.
LA  - eng
LA  - por
PT  - Journal Article
TT  - Avaliacao do teste de respiracao espontanea na extubacao de neonatos pre-termo.
PL  - Brazil
TA  - Rev Bras Ter Intensiva
JT  - Revista Brasileira de terapia intensiva
JID - 9506692
EDAT- 2010/06/01 00:00
MHDA- 2010/06/01 00:01
CRDT- 2014/10/11 06:00
PHST- 2010/02/04 00:00 [received]
PHST- 2010/05/15 00:00 [accepted]
PHST- 2014/10/11 06:00 [entrez]
PHST- 2010/06/01 00:00 [pubmed]
PHST- 2010/06/01 00:01 [medline]
AID - S0103-507X2010000200010 [pii]
PST - ppublish
SO  - Rev Bras Ter Intensiva. 2010 Jun;22(2):159-65.


PMID- 25303753
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151026
LR  - 20220310
IS  - 0103-507X (Print)
IS  - 0103-507X (Linking)
VI  - 22
IP  - 2
DP  - 2010 Jun
TI  - Perceptions about end of life treatment in Argentina, Brazil and Uruguay
      intensive care units.
PG  - 125-32
LID - S0103-507X2010000200005 [pii]
AB  - ABSTRACT OBJECTIVE: To evaluate end-of-life procedures in intensive care units.
      METHODS: A questionnaire was prepared by the End-of-Life Study Group of the
      Argentinean, Brazilian and Uruguayan Intensive Care societies, collecting data on
      the participants demographics, institutions and limit therapeutic effort (LTE)
      decision making process. During this cross sectional study, the societies
      multidisciplinary teams members completed the questionnaire either during
      scientific meetings or online. The variables were analyzed with the Chi-square
      test, with a p<0.05 significance level. RESULTS: 420 professionals completed the 
      questionnaire. The Brazilian units had more beds, unrestricted visit was less
      frequent, their professionals were younger and worked more recently in intensive 
      care units, and more non-medical professionals completed the questionnaire. Three
      visits daily was the more usual number of visits for the three countries. The
      most influencing LTE factors were prognosis, co-morbidities, and therapeutic
      futility. In the three countries, more than 90% of the completers had already
      made LTE decisions. Cardiopulmonary resuscitation, vasoactive drugs
      administration, dialysis and parenteral nutrition were the most suspended/refused
      therapies in the three countries. Suspension of mechanic ventilation was more
      frequent in Argentina, followed by Uruguay. Sedation and analgesia were the less 
      suspended therapies in the three countries. Legal definement and ethical issues
      were mentioned as the main barriers for the LTE decision making process.
      CONCLUSION: LTE decisions are frequent among the professionals working in the
      three countries intensive care units. We found a more proactive LTE decision
      making trend In Argentina, and more equity for decisions distribution in Uruguay.
      This difference appears to be related to the participants different ages,
      experiences, professional types and genders.
FAU - Moritz, Rachel Duarte
AU  - Moritz RD
AD  - Associacao de Medicina Intensiva Brasileira, Brasil.
FAU - Deicas, Alberto
AU  - Deicas A
AD  - Sociedade Uruguaia de Medicina Intensiva, Uruguai.
FAU - Rossini, Juan Pablo
AU  - Rossini JP
AD  - Sociedade Argentina de Terapia Intensiva, Argentina.
FAU - Silva, Nilton Brandao da
AU  - Silva NB
AD  - Associacao de Medicina Intensiva Brasileira, Brasil.
FAU - Lago, Patricia Miranda do
AU  - Lago PM
AD  - Associacao de Medicina Intensiva Brasileira, Brasil.
FAU - Machado, Fernando Osni
AU  - Machado FO
AD  - Associacao de Medicina Intensiva Brasileira, Brasil.
LA  - eng
LA  - por
PT  - Journal Article
TT  - Percepcao dos profissionais sobre o tratamento no fim da vida, nas unidades de
      terapia intensiva da Argentina, Brasil e Uruguai.
PL  - Brazil
TA  - Rev Bras Ter Intensiva
JT  - Revista Brasileira de terapia intensiva
JID - 9506692
EDAT- 2010/06/01 00:00
MHDA- 2010/06/01 00:01
CRDT- 2014/10/11 06:00
PHST- 2010/05/08 00:00 [received]
PHST- 2010/06/14 00:00 [accepted]
PHST- 2014/10/11 06:00 [entrez]
PHST- 2010/06/01 00:00 [pubmed]
PHST- 2010/06/01 00:01 [medline]
AID - S0103-507X2010000200005 [pii]
PST - ppublish
SO  - Rev Bras Ter Intensiva. 2010 Jun;22(2):125-32.


PMID- 24037467
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130917
LR  - 20160511
IS  - 1876-3413 (Print)
IS  - 1876-3405 (Linking)
VI  - 2
IP  - 2
DP  - 2010 Jun
TI  - Global application of therapeutic hypothermia to treat perinatal asphyxial
      encephalopathy.
PG  - 79-81
LID - 10.1016/j.inhe.2010.03.003 [doi]
AB  - Therapeutic hypothermia improves neurodevelopmental outcome following perinatal
      asphyxial encephalopathy and has now become 'standard of care' in industrialised 
      countries. However, none of the cooling trials so far have been conducted in
      developing countries, where approximately one million asphyxial deaths occur
      every year. Use of therapeutic hypothermia in such settings raises several
      clinical, pragmatic and ethical issues. We suggest that rigorous clinical trials 
      of cooling are required to ensure that a safe and effective neuroprotective
      therapy demonstrated in high resource settings does not become an unsafe and
      ineffective practice in low resource settings.
FAU - Thayyil, Sudhin
AU  - Thayyil S
AD  - UCL Institute for Women's Health, University College London, 86-96 Chenies Mews, 
      London, WC1E 6HX, United Kingdom.
FAU - Bhutta, Zulfiqar A
AU  - Bhutta ZA
FAU - Ramji, Siddarth
AU  - Ramji S
FAU - Costello, Anthony M
AU  - Costello AM
FAU - Robertson, Nicola J
AU  - Robertson NJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int Health
JT  - International health
JID - 101517095
EDAT- 2010/06/01 00:00
MHDA- 2010/06/01 00:01
CRDT- 2013/09/17 06:00
PHST- 2013/09/17 06:00 [entrez]
PHST- 2010/06/01 00:00 [pubmed]
PHST- 2010/06/01 00:01 [medline]
AID - j.inhe.2010.03.003 [pii]
AID - 10.1016/j.inhe.2010.03.003 [doi]
PST - ppublish
SO  - Int Health. 2010 Jun;2(2):79-81. doi: 10.1016/j.inhe.2010.03.003.


PMID- 23270044
OWN - NLM
STAT- MEDLINE
DCOM- 20130116
LR  - 20121228
IS  - 0038-3139 (Print)
IS  - 0038-3139 (Linking)
VI  - 106
IP  - 3
DP  - 2010 Jun
TI  - SC Pandemic Influenza Ethics Taskforce guidelines.
PG  - 129-30
FAU - Ball, Robert T Jr
AU  - Ball RT Jr
FAU - Schneider, Phil A
AU  - Schneider PA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J S C Med Assoc
JT  - Journal of the South Carolina Medical Association (1975)
JID - 7503045
SB  - IM
MH  - *Guidelines as Topic
MH  - Humans
MH  - Influenza, Human/*epidemiology
MH  - Pandemics
MH  - Resource Allocation/*ethics
MH  - South Carolina
EDAT- 2010/06/01 00:00
MHDA- 2013/01/17 06:00
CRDT- 2012/12/29 06:00
PHST- 2012/12/29 06:00 [entrez]
PHST- 2010/06/01 00:00 [pubmed]
PHST- 2013/01/17 06:00 [medline]
PST - ppublish
SO  - J S C Med Assoc. 2010 Jun;106(3):129-30.


PMID- 22984375
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130917
LR  - 20211021
IS  - 1876-3413 (Print)
IS  - 1876-3405 (Linking)
VI  - 2
IP  - 2
DP  - 2010 Jun
TI  - Community engagement on the Thai-Burmese border: rationale, experience and
      lessons learnt.
PG  - 123-9
LID - 10.1016/j.inhe.2010.02.001 [doi]
AB  - Community engagement is increasingly promoted in developing countries, especially
      in international health research, but there is little published experience. The
      Shoklo Malaria Research Unit (SMRU) conducts research with refugees, migrant
      workers, displaced people, and day migrants on the Thai-Burmese border, and has
      recently facilitated the set up of the Tak Province Border Community Ethics
      Advisory Board (T-CAB). Valuable lessons have been learnt from consultation with 
      the T-CAB especially in the area of participant recruitment and the informed
      consent process. A lot of new research questions have emerged from consultation
      with the T-CAB. This paper describes our experience, lessons learnt and the
      unique challenges faced working with the T-CAB from its initial conception to
      date. We conclude that consultation with the T-CAB has made improvements in our
      research in particular operational and ethical aspects of our studies.
FAU - Cheah, Phaik Yeong
AU  - Cheah PY
AD  - Shoklo Malaria Research Unit, Mae Sot, Tak, 63110 Thailand ; Mahidol Oxford
      Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol
      University, Bangkok, 10400 Thailand ; Centre for Tropical Medicine, Nuffield
      Department of Clinical Medicine, University of Oxford, OX3 7LJ, United Kingdom.
FAU - Lwin, Khin Maung
AU  - Lwin KM
FAU - Phaiphun, Lucy
AU  - Phaiphun L
FAU - Maelankiri, Ladda
AU  - Maelankiri L
FAU - Parker, Michael
AU  - Parker M
FAU - Day, Nicholas P
AU  - Day NP
FAU - White, Nicholas J
AU  - White NJ
FAU - Nosten, Francois
AU  - Nosten F
LA  - eng
GR  - 090207/Z/09/Z/WT_/Wellcome Trust/United Kingdom
GR  - 093956/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PL  - England
TA  - Int Health
JT  - International health
JID - 101517095
PMC - PMC3442337
MID - UKMS49804
OID - NLM: UKMS49804
EDAT- 2010/06/01 00:00
MHDA- 2010/06/01 00:01
CRDT- 2012/09/18 06:00
PHST- 2012/09/18 06:00 [entrez]
PHST- 2010/06/01 00:00 [pubmed]
PHST- 2010/06/01 00:01 [medline]
AID - 10.1016/j.inhe.2010.02.001 [doi]
PST - ppublish
SO  - Int Health. 2010 Jun;2(2):123-9. doi: 10.1016/j.inhe.2010.02.001.


PMID- 22810324
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20120719
IS  - 1080-2371 (Print)
IS  - 1080-2371 (Linking)
VI  - 16
IP  - 3 Epilepsy
DP  - 2010 Jun
TI  - Ethical perspectives in neurology: ethical considerations in sudden unexplained
      death in epilepsy.
PG  - 242-5
LID - 10.1212/01.CON.0000368242.72480.07 [doi]
FAU - Hamid, Hamada
AU  - Hamid H
FAU - Nass, Ruth
AU  - Nass R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Continuum (Minneap Minn)
JT  - Continuum (Minneapolis, Minn.)
JID - 9509333
EDAT- 2010/06/01 00:00
MHDA- 2010/06/01 00:01
CRDT- 2012/07/20 06:00
PHST- 2012/07/20 06:00 [entrez]
PHST- 2010/06/01 00:00 [pubmed]
PHST- 2010/06/01 00:01 [medline]
AID - 10.1212/01.CON.0000368242.72480.07 [doi]
AID - 00132979-201006000-00014 [pii]
PST - ppublish
SO  - Continuum (Minneap Minn). 2010 Jun;16(3 Epilepsy):242-5. doi:
      10.1212/01.CON.0000368242.72480.07.


PMID- 22558060
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1878-5158 (Print)
IS  - 1878-5158 (Linking)
VI  - 1
IP  - 2
DP  - 2010 Jun
TI  - Do Ethicists and Political Philosophers Vote More Often Than Other Professors?
PG  - 189-199
AB  - If philosophical moral reflection improves moral behavior, one might expect
      ethics professors to behave morally better than socially similar non-ethicists.
      Under the assumption that forms of political engagement such as voting have moral
      worth, we looked at the rate at which a sample of professional ethicists-and
      political philosophers as a subgroup of ethicists-voted in eight years' worth of 
      elections. We compared ethicists' and political philosophers' voting rates with
      the voting rates of three other groups: philosophers not specializing in ethics, 
      political scientists, and a comparison group of professors specializing in
      neither philosophy nor political science. All groups voted at about the same
      rate, except for the political scientists, who voted about 10-15% more often. On 
      the face of it, this finding conflicts with the expectation that ethicists will
      behave more responsibly than non-ethicists. ELECTRONIC SUPPLEMENTARY MATERIAL:
      The online version of this article (doi:10.1007/s13164-009-0011-6) contains
      supplementary material, which is available to authorized users.
FAU - Schwitzgebel, Eric
AU  - Schwitzgebel E
FAU - Rust, Joshua
AU  - Rust J
LA  - eng
PT  - Journal Article
DEP - 20091201
PL  - Netherlands
TA  - Rev Philos Psychol
JT  - Review of philosophy and psychology
JID - 101569796
PMC - PMC3339026
EDAT- 2010/06/01 00:00
MHDA- 2010/06/01 00:01
CRDT- 2012/05/05 06:00
PHST- 2012/05/05 06:00 [entrez]
PHST- 2010/06/01 00:00 [pubmed]
PHST- 2010/06/01 00:01 [medline]
AID - 10.1007/s13164-009-0011-6 [doi]
AID - 11 [pii]
PST - ppublish
SO  - Rev Philos Psychol. 2010 Jun;1(2):189-199. doi: 10.1007/s13164-009-0011-6. Epub
      2009 Dec 1.


PMID- 22462289
OWN - NLM
STAT- MEDLINE
DCOM- 20120503
LR  - 20170203
IS  - 0723-1393 (Print)
IS  - 0723-1393 (Linking)
VI  - 29
IP  - 2
DP  - 2010 Jun
TI  - Advance treatment directive: a tool for dialogue or self-protection in the
      physician-patient relation?
PG  - 263-73
AB  - The authors intend to assess the efficacy of the advance treatment directive as a
      tool for involving patients into the decision-making process and the actual
      implementation of the physician-patient communication. It seems particularly
      appropriate to distinguish between "generic" advance directive, happening outside
      of the physician-patient relation, and documents drafted with the assistance of
      care providers, in the context of such an information and communication process. 
      That is, in order to guarantee the awareness of patients and the pertinence of
      the disclosed indication to the current situation with reference to the
      subject-matter of advance treatment directive. In addition, considering the
      different ways for the will of a patient to be conveyed--written statements,
      unexpressed will reported by witnesses, expressed will in an intelligible way by 
      patients with severe verbal communication deficit--it is deemed important to
      identify the formal requirements for the validity of the above expressions of
      will. From an ethical standpoint, if we transcend a merely contract-centred and
      defensive vision of the physician/patient relation, the positive meaning of
      autonomy lays in its effective enforcement in the decision-making and care
      processes, with regard to the defined circumstances and the specific objects it
      refers to. Physician/patient communication means, for the purposes of this
      discussion, a preferential tool to balance the substantially asymmetrical
      relation between a physician and a patient: the process is based on a path of
      mutual recognition where the formal protection of each other's scopes of
      competency and right to self-determination stand for an essential requisite,
      though only preliminarily, to the actual accomplishment of consent in its
      cognitive and practical features.
FAU - Buzzi, E M
AU  - Buzzi EM
AD  - Department of Surgery, Radiology and Forensic Medicine, Humanities and Forensic
      Sciences Section, Faculty of Medicine and Surgery, University of Brescia, Italy.
FAU - Delbon, P
AU  - Delbon P
FAU - Reedy, S
AU  - Reedy S
FAU - Conti, A
AU  - Conti A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Law
JT  - Medicine and law
JID - 8218185
SB  - IM
MH  - Advance Directives/*ethics
MH  - Decision Making/*ethics
MH  - Defensive Medicine/*ethics/standards
MH  - Humans
MH  - Physician-Patient Relations/*ethics
EDAT- 2010/06/01 00:00
MHDA- 2012/05/04 06:00
CRDT- 2012/04/03 06:00
PHST- 2012/04/03 06:00 [entrez]
PHST- 2010/06/01 00:00 [pubmed]
PHST- 2012/05/04 06:00 [medline]
PST - ppublish
SO  - Med Law. 2010 Jun;29(2):263-73.


PMID- 22462288
OWN - NLM
STAT- MEDLINE
DCOM- 20120503
LR  - 20170203
IS  - 0723-1393 (Print)
IS  - 0723-1393 (Linking)
VI  - 29
IP  - 2
DP  - 2010 Jun
TI  - Patients' rights a case for a Charter of Participant Rights in Pre-Market Drug
      Trials: the next evolution.
PG  - 239-61
AB  - Since the first publication of Medicine and Law thirty years ago, there have been
      significant international advances in patient rights and participant protections 
      in clinical trials. Despite such advances, there are still alarming reports of
      actual or perceived breaches in ethical standards by Institutions, Investigators 
      and Sponsors of pre-market drug clinical trials. This is particularly disturbing 
      as these trials involve participants in the testing of an investigational drug
      before its full safety, effectiveness, and clinical outcomes are understood.
      Moreover, the study design may randomize participants (recruited because they
      have specific diseases or conditions) into a group receiving a placebo or
      comparator drug versus a group receiving the investigational drug. The proposed
      Charter of Participant Rights in Pre-Market Drug Trials reflects the growing
      trend towards a participant-centred approach to the implementation and
      enforcement of participant rights. The development and adoption of the Charter is
      the next natural step towards the guarantee of rights in pre-market clinical drug
      trials.
FAU - Sheldon, C Tess
AU  - Sheldon CT
AD  - Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario,
      Canada.
FAU - Ferris, Lorraine E
AU  - Ferris LE
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Law
JT  - Medicine and law
JID - 8218185
RN  - 0 (Drugs, Investigational)
SB  - IM
MH  - Access to Information/ethics
MH  - Clinical Trials as Topic/*ethics/standards
MH  - Developing Countries
MH  - *Drugs, Investigational
MH  - Humans
MH  - Informed Consent/ethics/standards
MH  - International Cooperation
MH  - Patient Rights/*ethics/standards
MH  - Patient Safety/*standards
MH  - Patient Selection/ethics
EDAT- 2010/06/01 00:00
MHDA- 2012/05/04 06:00
CRDT- 2012/04/03 06:00
PHST- 2012/04/03 06:00 [entrez]
PHST- 2010/06/01 00:00 [pubmed]
PHST- 2012/05/04 06:00 [medline]
PST - ppublish
SO  - Med Law. 2010 Jun;29(2):239-61.


PMID- 22462285
OWN - NLM
STAT- MEDLINE
DCOM- 20120503
LR  - 20170203
IS  - 0723-1393 (Print)
IS  - 0723-1393 (Linking)
VI  - 29
IP  - 2
DP  - 2010 Jun
TI  - Ethics review of health research on human participants in South Africa.
PG  - 205-15
AB  - In terms of South African legislation, all health research on human participants 
      must be submitted to an accredited research ethics committee for independent
      ethics review. Health research covers a broad spectrum of research, including
      clinical trials. This article sets out the ethical-legal framework for the
      functioning and composition of such committees. It also deals with the newly
      created National Health Research Ethics Council, which registers and audits
      health research ethics committees. Special attention is given to the conduct of
      clinical trials. In conclusion, it is submitted that the National Health Act, the
      Draft Regulations Relating to Research on Human Subjects, and two sets of ethical
      guidelines adopted by the Department of Health provide a much needed and coherent
      ethical-legal framework for research in South Africa.
FAU - van Wyk, Christa
AU  - van Wyk C
AD  - Department of Jurisprudence, University of South Africa.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Med Law
JT  - Medicine and law
JID - 8218185
SB  - IM
MH  - Biomedical Research/*ethics/legislation & jurisprudence
MH  - Ethics Committees, Research/legislation & jurisprudence/*organization &
      administration
MH  - Health Services Research/*ethics/legislation & jurisprudence
MH  - Human Experimentation/*ethics/legislation & jurisprudence
MH  - Humans
MH  - South Africa
EDAT- 2010/06/01 00:00
MHDA- 2012/05/04 06:00
CRDT- 2012/04/03 06:00
PHST- 2012/04/03 06:00 [entrez]
PHST- 2010/06/01 00:00 [pubmed]
PHST- 2012/05/04 06:00 [medline]
PST - ppublish
SO  - Med Law. 2010 Jun;29(2):205-15.


PMID- 22462284
OWN - NLM
STAT- MEDLINE
DCOM- 20120503
LR  - 20170203
IS  - 0723-1393 (Print)
IS  - 0723-1393 (Linking)
VI  - 29
IP  - 2
DP  - 2010 Jun
TI  - Ethical dilemmas of Statutory Committees for involuntary hospitalization of
      mentally ill patients.
PG  - 193-204
AB  - Mentally ill patients whose reality judgements are severely impaired by reason of
      their illness and consequently present a danger to themselves and others, may be 
      involuntarily admitted to a secure psychiatric ward for the safety of both
      themselves and the public. The Israeli Statute for the Treatment of Mentally Ill 
      Patients, enacted in 1955 and amended in 1991, sets out rules and procedures for 
      such involuntary confinement, and grants authority to the MOH District
      Psychiatrist to issue initial involuntary admission orders. However, a patient
      can appeal a District Psychiatrist order before a judicial statutory committee,
      comprising two senior psychiatrists and a legal expert in the capacity of
      magistrate. Such committee is also the statutory forum for determining whether
      involuntary hospitalization should be extended. The committee may quite often
      face ethical dilemmas when, on the one hand, there is no question that the
      patient's judgement is severely impaired but on the other hand, his/her condition
      does not fully meet the criteria of the statutory requirements for involuntary
      confinement. This paper discusses the legal aspects and requirements of
      involuntary admissions vis-a-vis the ethical dilemmas that such Statutory
      Committees may face when deciding to extend hospitalization or to release the
      patient from committal. The paper shall also illustrate dilemmas actually brought
      before the Committee that have ended in a final ruling that balances moral
      ethical dilemmas with the strict statutory requirements.
FAU - Wolfman, Samuel
AU  - Wolfman S
AD  - Law School of Zefat Academic College, Zefat, Israel.
FAU - Shaked, Tali
AU  - Shaked T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Law
JT  - Medicine and law
JID - 8218185
SB  - IM
MH  - Commitment of Mentally Ill/*legislation & jurisprudence
MH  - Dangerous Behavior
MH  - Ethical Analysis
MH  - Humans
MH  - Israel
MH  - Mental Competency/psychology/*standards
MH  - Mentally Ill Persons/*legislation & jurisprudence/psychology
MH  - Self-Injurious Behavior/psychology
EDAT- 2010/06/01 00:00
MHDA- 2012/05/04 06:00
CRDT- 2012/04/03 06:00
PHST- 2012/04/03 06:00 [entrez]
PHST- 2010/06/01 00:00 [pubmed]
PHST- 2012/05/04 06:00 [medline]
PST - ppublish
SO  - Med Law. 2010 Jun;29(2):193-204.


PMID- 22402045
OWN - NLM
STAT- MEDLINE
DCOM- 20120807
LR  - 20211203
IS  - 1939-1536 (Electronic)
IS  - 0033-3204 (Linking)
VI  - 47
IP  - 2
DP  - 2010 Jun
TI  - Reflections of a gay male psychotherapist.
PG  - 177-85
LID - 10.1037/a0019757 [doi]
AB  - Issues of diversity and multiculturalism are typically framed and conceptualized 
      in terms of client characteristics. This is reflected in the literature on
      competent and ethical treatment of lesbian, gay, bisexual, and transgender (LGBT)
      individuals. However, when it comes to personal characteristics of the therapists
      involved, little has been written, save the obvious proscriptions against
      personal bias and misinformation in conducting psychotherapy. This article
      represents the personal reflections and feelings of a European American gay male 
      psychologist with 30 years' experience working with the LGBT community.
      Intersections of sexual orientation and gender identity with race/ethnicity, age,
      health factors, and socioeconomic status are explored as the effects of therapist
      characteristics on the therapeutic process are considered. Observations about
      client differences, as well as therapist differences, are made in such a way that
      the reader might extrapolate to his or her own practice.
CI  - PsycINFO Database Record (c) 2010 APA, all rights reserved.
FAU - Haldeman, Douglas C
AU  - Haldeman DC
AD  - Department of Psychology, University of Washington, USA. doughaldeman@aol.com
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Psychotherapy (Chic)
JT  - Psychotherapy (Chicago, Ill.)
JID - 2984829R
SB  - IM
MH  - Adult
MH  - African Americans/psychology
MH  - Anxiety Disorders/psychology/therapy
MH  - Bisexuality/psychology
MH  - Cultural Diversity
MH  - Depressive Disorder/psychology/therapy
MH  - Ethnicity/*psychology
MH  - Female
MH  - *Gender Identity
MH  - Health Status
MH  - Homosexuality, Female/psychology
MH  - Homosexuality, Male/*psychology
MH  - Humans
MH  - Male
MH  - *Prejudice
MH  - *Professional-Patient Relations
MH  - *Psychotherapy
MH  - Rejection, Psychology
MH  - Self Concept
MH  - Self Disclosure
MH  - Sexual Behavior
MH  - Social Alienation
MH  - *Social Identification
MH  - Social Stigma
MH  - Socioeconomic Factors
MH  - Stereotyping
MH  - Whites/psychology
EDAT- 2010/06/01 00:00
MHDA- 2012/08/08 06:00
CRDT- 2012/03/10 06:00
PHST- 2012/03/10 06:00 [entrez]
PHST- 2010/06/01 00:00 [pubmed]
PHST- 2012/08/08 06:00 [medline]
AID - 2010-13424-007 [pii]
AID - 10.1037/a0019757 [doi]
PST - ppublish
SO  - Psychotherapy (Chic). 2010 Jun;47(2):177-85. doi: 10.1037/a0019757.


PMID- 20508997
OWN - NLM
STAT- MEDLINE
DCOM- 20100920
LR  - 20100616
IS  - 1661-4917 (Electronic)
IS  - 0004-069X (Linking)
VI  - 58
IP  - 4
DP  - 2010 Aug
TI  - Don't get spooked! How to collaborate with a professional medical communicator
      (and avoid ghostwriting).
PG  - 255-61
LID - 10.1007/s00005-010-0080-3 [doi]
AB  - Substantial confusion exists about the role of medical writers and editors
      (hereafter, medical communicators) in medical publication. Much of the confusion 
      is due to the failure to recognize the difference between terms. Ghostwriting is 
      unethical, whereas professional medical communication refers to legitimate
      writing and editing services provided by individuals who comply with ethical
      guidelines. The purpose of this article is to shed light on this subject by
      reviewing relevant guidelines and by providing practical tips for authors
      interested in collaborating with medical communicators. Specifically, this
      article addresses a series of questions, such as what to expect from medical
      communicators, how to evaluate them, and how to collaborate ethically and
      efficiently with them. To ensure that the process is ethical, authors should
      begin collaborating with the medical communicator early in the process, continue 
      doing so throughout manuscript development, and control manuscript content. In
      addition, authors should disclose substantial contributions and funding sources
      of the medical communicator and all other individuals not meeting authorship
      criteria. To ensure that the process is efficient, authors should delegate
      time-consuming technical writing and editing tasks to the medical communicator.
FAU - Hamilton, Cindy W
AU  - Hamilton CW
AD  - Hamilton House, 844 Quail Point Cove, Virginia Beach, VA 23454, USA.
      cindy@hamiltonhouseva.com
LA  - eng
PT  - Journal Article
DEP - 20100528
PL  - Switzerland
TA  - Arch Immunol Ther Exp (Warsz)
JT  - Archivum immunologiae et therapiae experimentalis
JID - 0114365
SB  - IM
MH  - *Authorship
MH  - Editorial Policies
MH  - Humans
MH  - *Journalism, Medical/standards
MH  - Periodicals as Topic
MH  - *Publishing/ethics/standards
EDAT- 2010/05/29 06:00
MHDA- 2010/09/21 06:00
CRDT- 2010/05/29 06:00
PHST- 2010/04/22 00:00 [received]
PHST- 2010/05/04 00:00 [accepted]
PHST- 2010/05/29 06:00 [entrez]
PHST- 2010/05/29 06:00 [pubmed]
PHST- 2010/09/21 06:00 [medline]
AID - 10.1007/s00005-010-0080-3 [doi]
PST - ppublish
SO  - Arch Immunol Ther Exp (Warsz). 2010 Aug;58(4):255-61. doi:
      10.1007/s00005-010-0080-3. Epub 2010 May 28.


PMID- 20507687
OWN - NLM
STAT- MEDLINE
DCOM- 20100621
LR  - 20100528
IS  - 1469-2147 (Electronic)
IS  - 0963-1801 (Linking)
VI  - 19
IP  - 3
DP  - 2010 Jul
TI  - Developing a model of healthcare ethics support in Croatia.
PG  - 395-401
LID - 10.1017/S0963180110000174 [doi]
FAU - Borovecki, Ana
AU  - Borovecki A
FAU - Makar-Ausperger, Ksenija
AU  - Makar-Ausperger K
FAU - Francetic, Igor
AU  - Francetic I
FAU - Babic-Bosnac, Sanja
AU  - Babic-Bosnac S
FAU - Gordijn, Bert
AU  - Gordijn B
FAU - Steinkamp, Norbert
AU  - Steinkamp N
FAU - Oreskovic, Stjepan
AU  - Oreskovic S
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Camb Q Healthc Ethics
JT  - Cambridge quarterly of healthcare ethics : CQ : the international journal of
      healthcare ethics committees
JID - 9208482
SB  - IM
MH  - Anorexia/etiology
MH  - Bioethical Issues
MH  - Caregivers
MH  - Croatia
MH  - Delivery of Health Care/*ethics
MH  - Down Syndrome/complications
MH  - Enteral Nutrition/*ethics
MH  - Ethical Analysis
MH  - *Ethics Committees
MH  - Ethics Consultation/trends
MH  - Female
MH  - Health Personnel/*education
MH  - Humans
MH  - Middle Aged
MH  - Parents
MH  - Quality of Life
MH  - Withholding Treatment/*ethics/legislation & jurisprudence
EDAT- 2010/05/29 06:00
MHDA- 2010/06/22 06:00
CRDT- 2010/05/29 06:00
PHST- 2010/05/29 06:00 [entrez]
PHST- 2010/05/29 06:00 [pubmed]
PHST- 2010/06/22 06:00 [medline]
AID - S0963180110000174 [pii]
AID - 10.1017/S0963180110000174 [doi]
PST - ppublish
SO  - Camb Q Healthc Ethics. 2010 Jul;19(3):395-401. doi: 10.1017/S0963180110000174.


PMID- 20507686
OWN - NLM
STAT- MEDLINE
DCOM- 20100621
LR  - 20100528
IS  - 1469-2147 (Electronic)
IS  - 0963-1801 (Linking)
VI  - 19
IP  - 3
DP  - 2010 Jul
TI  - The cultural context of end-of-life ethics: a comparison of Germany and Israel.
PG  - 381-94
LID - 10.1017/S0963180110000162 [doi]
FAU - Schicktanz, Silke
AU  - Schicktanz S
FAU - Raz, Aviad
AU  - Raz A
FAU - Shalev, Carmel
AU  - Shalev C
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - Camb Q Healthc Ethics
JT  - Cambridge quarterly of healthcare ethics : CQ : the international journal of
      healthcare ethics committees
JID - 9208482
SB  - IM
MH  - *Cultural Characteristics
MH  - Decision Making
MH  - Euthanasia/ethics/history/legislation & jurisprudence
MH  - Germany
MH  - History, 20th Century
MH  - *Holocaust/ethics/history/legislation & jurisprudence
MH  - Humans
MH  - Israel
MH  - *Jews/psychology
MH  - National Socialism
MH  - Personal Autonomy
MH  - *Religion
MH  - *Suicide, Assisted/ethics/legislation & jurisprudence/trends
MH  - Terminal Care/*ethics
MH  - *Wedge Argument
EDAT- 2010/05/29 06:00
MHDA- 2010/06/22 06:00
CRDT- 2010/05/29 06:00
PHST- 2010/05/29 06:00 [entrez]
PHST- 2010/05/29 06:00 [pubmed]
PHST- 2010/06/22 06:00 [medline]
AID - S0963180110000162 [pii]
AID - 10.1017/S0963180110000162 [doi]
PST - ppublish
SO  - Camb Q Healthc Ethics. 2010 Jul;19(3):381-94. doi: 10.1017/S0963180110000162.


PMID- 20507684
OWN - NLM
STAT- MEDLINE
DCOM- 20100621
LR  - 20100528
IS  - 1469-2147 (Electronic)
IS  - 0963-1801 (Linking)
VI  - 19
IP  - 3
DP  - 2010 Jul
TI  - Commanding the "be fruitful and multiply" directive: reproductive ethics, law,
      and policy in Israel.
PG  - 363-71
LID - 10.1017/S0963180110000149 [doi]
FAU - Sperling, Daniel
AU  - Sperling D
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Camb Q Healthc Ethics
JT  - Cambridge quarterly of healthcare ethics : CQ : the international journal of
      healthcare ethics committees
JID - 9208482
SB  - IM
MH  - Abortion, Induced/ethics/*legislation & jurisprudence/trends
MH  - Female
MH  - Fertilization in Vitro/legislation & jurisprudence
MH  - Humans
MH  - Israel
MH  - Male
MH  - *Mothers
MH  - *Public Policy/legislation & jurisprudence/trends
MH  - *Religion
MH  - *Reproduction/ethics
MH  - *Social Responsibility
MH  - Women's Rights
EDAT- 2010/05/29 06:00
MHDA- 2010/06/22 06:00
CRDT- 2010/05/29 06:00
PHST- 2010/05/29 06:00 [entrez]
PHST- 2010/05/29 06:00 [pubmed]
PHST- 2010/06/22 06:00 [medline]
AID - S0963180110000149 [pii]
AID - 10.1017/S0963180110000149 [doi]
PST - ppublish
SO  - Camb Q Healthc Ethics. 2010 Jul;19(3):363-71. doi: 10.1017/S0963180110000149.


PMID- 20506695
OWN - NLM
STAT- MEDLINE
DCOM- 20100611
LR  - 20211020
IS  - 1054-6863 (Print)
IS  - 1054-6863 (Linking)
VI  - 20
IP  - 1
DP  - 2010 Mar
TI  - Extending clinical equipoise to phase 1 trials involving patients: unresolved
      problems.
PG  - 75-98
AB  - Notwithstanding requirements for scientific/social value and risk/benefit
      proportionality in major research ethics policies, there are no widely accepted
      standards for these judgments in Phase 1 trials. This paper examines whether the 
      principle of clinical equipoise can be used as a standard for assessing the ratio
      of risk to direct-benefit presented by drugs administered in one category of
      Phase 1 study--first-in-human trials involving patients. On the basis of the
      supporting evidence for, and architecture of, Phase 1 studies, the articles
      offers two provisional conclusions: (1) the risks of drug administration in such 
      trials cannot generally be justified on therapeutic grounds but by appeal to the 
      social value of the research; and (2) a framework for adjudicating the ratio of
      risk/social-value must be developed.
FAU - Anderson, James A
AU  - Anderson JA
AD  - Biomedical Ethics Unit, Faculty of Medicine, McGill University, Montreal, Quebec,
      Canada.
FAU - Kimmelman, Jonathan
AU  - Kimmelman J
LA  - eng
GR  - 102823-1/CAPMC/ CIHR/Canada
GR  - /FRN 102823/CAPMC/ CIHR/Canada
GR  - /MOP 68835/CAPMC/ CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Kennedy Inst Ethics J
JT  - Kennedy Institute of Ethics journal
JID - 9109135
SB  - IM
MH  - *Clinical Trials, Phase I as Topic/methods/standards
MH  - Ethics, Research
MH  - Humans
MH  - Research Subjects
MH  - Risk
MH  - Social Values
MH  - *Therapeutic Equipoise
PMC - PMC4482670
MID - CAMS4750
OID - NLM: CAMS4750
EDAT- 2010/05/29 06:00
MHDA- 2010/06/12 06:00
CRDT- 2010/05/29 06:00
PHST- 2010/05/29 06:00 [entrez]
PHST- 2010/05/29 06:00 [pubmed]
PHST- 2010/06/12 06:00 [medline]
AID - 10.1353/ken.0.0307 [doi]
PST - ppublish
SO  - Kennedy Inst Ethics J. 2010 Mar;20(1):75-98. doi: 10.1353/ken.0.0307.


PMID- 20506693
OWN - NLM
STAT- MEDLINE
DCOM- 20100611
LR  - 20191111
IS  - 1054-6863 (Print)
IS  - 1054-6863 (Linking)
VI  - 20
IP  - 1
DP  - 2010 Mar
TI  - International stem cell tourism and the need for effective regulation. Part I:
      Stem cell tourism in Russia and India: clinical research, innovative treatment,
      or unproven hype?
PG  - 27-49
AB  - Persons with serious and disabling medical conditions have traveled abroad in
      search of stem cell treatments in recent years. However, weak or nonexistent
      oversight systems in some countries provide insufficient patient protections
      against unproven stem cell treatments, raising concerns about exposure to harm
      and exploitation. The present article, the first of two, describes and analyzes
      stem cell tourism in Russia and India and addresses several scientific/medical,
      ethical, and policy issues raised by the provision of unproven stem cell-based
      treatments within them. The distinction between treatment based on proven
      clinical research and "innovative treatment" is addressed and the authors
      conclude that the innovations at issue constitute neither. Regulatory measures
      need to be developed or strengthened in accord with internationally accepted
      standards in such countries to protect those seeking stem cell treatments.
FAU - Cohen, Cynthia B
AU  - Cohen CB
AD  - Kennedy Institute of Ethics, Georgetown University, Washington, DC, USA.
FAU - Cohen, Peter J
AU  - Cohen PJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Kennedy Inst Ethics J
JT  - Kennedy Institute of Ethics journal
JID - 9109135
SB  - IM
CIN - Kennedy Inst Ethics J. 2011 Sep;21(3):vii-viii. PMID: 22073814
MH  - *Biomedical Research/legislation & jurisprudence/trends
MH  - Embryo Research/legislation & jurisprudence
MH  - *Health Policy/legislation & jurisprudence/trends
MH  - Humans
MH  - India
MH  - *Medical Tourism/legislation & jurisprudence/trends
MH  - Russia
MH  - *Stem Cell Transplantation/legislation & jurisprudence/trends
EDAT- 2010/05/29 06:00
MHDA- 2010/06/12 06:00
CRDT- 2010/05/29 06:00
PHST- 2010/05/29 06:00 [entrez]
PHST- 2010/05/29 06:00 [pubmed]
PHST- 2010/06/12 06:00 [medline]
AID - 10.1353/ken.0.0305 [doi]
PST - ppublish
SO  - Kennedy Inst Ethics J. 2010 Mar;20(1):27-49. doi: 10.1353/ken.0.0305.


PMID- 20506692
OWN - NLM
STAT- MEDLINE
DCOM- 20100611
LR  - 20191111
IS  - 1054-6863 (Print)
IS  - 1054-6863 (Linking)
VI  - 20
IP  - 1
DP  - 2010 Mar
TI  - What more in the name of god? Theologies and theodicies of faith healing.
PG  - 1-25
AB  - The recent deaths of two children from parental decisions to rely on faith
      healing rather than medical treatment raises fundamental questions about the
      extent and limits of religious liberty in a liberal democratic society. This
      essay seeks to identify and critically examine three central issues internal to
      the ethics of religious communities that engage in faith healing regarding
      children: (1) the various forms of religious and nonreligious justification for
      faith healing; (2) the moral, institutional, or metaphysical wrong of medical
      practice from the perspectives of faith-healing communities; (3) the explanation 
      or "theodicy" articulated by the religious community when faith healing does not 
      occur and a child dies. The essay finds that the holding in Prince v.
      Massachusetts that parents with religious convictions cannot enforce martyrdom on
      their children presents a guiding principle for medicine and public policy.
FAU - Campbell, Courtney S
AU  - Campbell CS
AD  - Department of Philosophy, Oregon State University, Corvallis, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Kennedy Inst Ethics J
JT  - Kennedy Institute of Ethics journal
JID - 9109135
SB  - IM
MH  - Adult
MH  - Ceremonial Behavior
MH  - Child
MH  - *Child Abuse
MH  - Child Advocacy
MH  - *Christian Science/psychology
MH  - *Faith Healing/psychology
MH  - Humans
MH  - *Parents/psychology
MH  - Religion and Medicine
MH  - Religion and Psychology
MH  - *Treatment Refusal/ethics
EDAT- 2010/05/29 06:00
MHDA- 2010/06/12 06:00
CRDT- 2010/05/29 06:00
PHST- 2010/05/29 06:00 [entrez]
PHST- 2010/05/29 06:00 [pubmed]
PHST- 2010/06/12 06:00 [medline]
AID - 10.1353/ken.0.0304 [doi]
PST - ppublish
SO  - Kennedy Inst Ethics J. 2010 Mar;20(1):1-25. doi: 10.1353/ken.0.0304.


PMID- 20506109
OWN - NLM
STAT- MEDLINE
DCOM- 20101112
LR  - 20100727
IS  - 1549-4918 (Electronic)
IS  - 1066-5099 (Linking)
VI  - 28
IP  - 7
DP  - 2010 Jul
TI  - Law, ethics, religion, and clinical translation in the 21st century-a
      conversation with Gonzalo Ulloa. Interview by Majlinda Lako, Alan O. Trounson and
      Susan Daher.
PG  - 1117-8
LID - 10.1002/stem.439 [doi]
FAU - Ulloa, Gonzalo
AU  - Ulloa G
LA  - eng
PT  - Interview
PL  - England
TA  - Stem Cells
JT  - Stem cells (Dayton, Ohio)
JID - 9304532
SB  - IM
MH  - *Bioethical Issues
MH  - Biomedical Research/ethics/legislation & jurisprudence
MH  - Humans
MH  - *Legislation as Topic
MH  - *Religion
MH  - Research Design/legislation & jurisprudence
MH  - Stem Cells
EDAT- 2010/05/28 06:00
MHDA- 2010/11/13 06:00
CRDT- 2010/05/28 06:00
PHST- 2010/05/28 06:00 [entrez]
PHST- 2010/05/28 06:00 [pubmed]
PHST- 2010/11/13 06:00 [medline]
AID - 10.1002/stem.439 [doi]
PST - ppublish
SO  - Stem Cells. 2010 Jul;28(7):1117-8. doi: 10.1002/stem.439.


PMID- 20506084
OWN - NLM
STAT- MEDLINE
DCOM- 20101105
LR  - 20100527
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 9
IP  - 2
DP  - 2010 May 25
TI  - An exploratory survey of professionals on the use of stored tissue samples from
      minors for genetic research.
PG  - 973-80
LID - 10.4238/vol9-2gmr781 [doi]
AB  - he ethical aspects of the use of stored tissue samples collected from minors are 
      of topical interest. However, the views of professionals working in the field of 
      genetics have not been investigated in depth anywhere. We conducted a survey
      among 194 such professionals in Belgium. This list was composed of the members of
      the High Council for Anthropogenetics, supplemented with all professionals
      working in the field of genetics that we found on the websites of the eight
      Belgian centers of human genetics and of the associated university registries. We
      achieved a response rate of 35.5%. The vast majority (92%) think that research on
      stored tissue samples is useful. Most respondents stated that parental consent is
      valid (82.5%), and 76.5% thought that children should also be given the right to 
      assent when they are able to comprehend the implications of the storage of
      biological samples and of genetic research. Slightly more than half put the age
      at which young people can understand storage or research rather high: 16-18 years
      (51 and 53.1%, respectively). Although there is some consensus in the literature 
      that donors should be allowed to give broad consent for future research on their 
      biological samples, only 47.6% in our survey thought that parents should be
      allowed to consent to any future research on their children's samples. The aim of
      our study was to give some basis for future ethical reflections and policies on
      the subject of stored tissue samples from minors for genetic research. We
      concluded that a large majority of Belgian researchers and clinicians in the
      field of genetic research think research on stored tissue samples from minors is 
      useful. They also think that parental consent for such research is valid, but
      that children should be allowed to assent as they grow older.
FAU - Hens, K
AU  - Hens K
AD  - Centre for Biomedical Ethics and Law, Katholieke Universiteit Leuven, Leuven,
      Belgium. Kristien.Hens@med.kuleuven.be
FAU - Snoeck, J
AU  - Snoeck J
FAU - Nys, H
AU  - Nys H
FAU - Cassiman, J-J
AU  - Cassiman JJ
FAU - Dierickx, K
AU  - Dierickx K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100525
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
SB  - IM
MH  - Adolescent
MH  - Attitude
MH  - Belgium
MH  - Child
MH  - Confidentiality/ethics
MH  - *Ethics, Research
MH  - Female
MH  - Genetic Research/*ethics
MH  - Humans
MH  - Informed Consent/ethics
MH  - Male
MH  - Minors
MH  - Parental Consent/ethics
MH  - Tissue Donors/ethics
MH  - Universities
EDAT- 2010/05/28 06:00
MHDA- 2010/11/06 06:00
CRDT- 2010/05/28 06:00
PHST- 2010/05/28 06:00 [entrez]
PHST- 2010/05/28 06:00 [pubmed]
PHST- 2010/11/06 06:00 [medline]
AID - gmr781 [pii]
AID - 10.4238/vol9-2gmr781 [doi]
PST - epublish
SO  - Genet Mol Res. 2010 May 25;9(2):973-80. doi: 10.4238/vol9-2gmr781.


PMID- 20505981
OWN - NLM
STAT- MEDLINE
DCOM- 20101210
LR  - 20211020
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 22
IP  - 2
DP  - 2010 Jun
TI  - Accessing the ethics of complex health care practices: would a "domains of ethics
      analysis" approach help?
PG  - 133-43
LID - 10.1007/s10730-010-9129-2 [doi]
AB  - This paper explores how using a "domains of ethics analysis" approach might
      constructively contribute to an enhanced understanding (among those without
      specialized ethics training) of ethically-complex health care practices through
      the consideration of one such sample practice, i.e., deep and continuous
      palliative sedation (DCPS). For this purpose, I select four sample ethics domains
      (from a variety of possible relevant domains) for use in the consideration of
      this practice, i.e., autonomous choice, motives, actions and consequences. These 
      particular domains were chosen because of their relevance to the analysis of DCPS
      and their relative ease of access to those without ethics training. The analysis 
      demonstrates that such an approach could facilitate the emergence of accessible
      arguments and discussion points that could enhance the understanding and
      appreciation of this and other health care practices with strong ethics
      dimensions.
FAU - Kirby, Jeffrey
AU  - Kirby J
AD  - Department of Bioethics, Faculty of Medicine, Dalhousie University, 5849
      University Avenue, Halifax, NS B3H 4H7, Canada. Jeffrey.Kirby@dal.ca
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
RN  - 0 (Hypnotics and Sedatives)
MH  - Decision Making/*ethics
MH  - Ethical Analysis/*methods
MH  - Euthanasia, Active/ethics
MH  - Humans
MH  - Hypnotics and Sedatives/*therapeutic use
MH  - Intention
MH  - Palliative Care/*ethics
MH  - Personal Autonomy
EDAT- 2010/05/28 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/05/28 06:00
PHST- 2010/05/28 06:00 [entrez]
PHST- 2010/05/28 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1007/s10730-010-9129-2 [doi]
PST - ppublish
SO  - HEC Forum. 2010 Jun;22(2):133-43. doi: 10.1007/s10730-010-9129-2.


PMID- 20505904
OWN - NLM
STAT- MEDLINE
DCOM- 20100928
LR  - 20181201
IS  - 0037-5675 (Print)
IS  - 0037-5675 (Linking)
VI  - 51
IP  - 4
DP  - 2010 Apr
TI  - Influenza pandemic and the duties of healthcare professionals.
PG  - 275-81
AB  - Preparing for an influenza pandemic presents significant scientific and
      administrative challenges. Governments can learn from measures implemented during
      past infectious disease epidemics and pandemics, and organise the nation's
      infrastructure and resources, particularly human resources, for efficient and
      effective mobilisation for such future events. This should include both the
      biomedical and ethical dimensions. In this paper, we discuss a critical ethical
      issue that will arise in preparation for and in response to an influenza
      pandemic, namely, the role and duties of healthcare workers. It is the aim of
      this paper to highlight the basis and scope of healthcare workers' duty of care
      during a pandemic.
FAU - Voo, T C
AU  - Voo TC
AD  - Centre for Biomedical Ethics, National University of Singapore, Yong Loo Lin
      School of Medicine, 10 Medical Drive, Singapore 117597. medvtc@nus.edu.sg
FAU - Capps, B
AU  - Capps B
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Singapore
TA  - Singapore Med J
JT  - Singapore medical journal
JID - 0404516
SB  - IM
CIN - Singapore Med J. 2010 Dec;51(12):973. PMID: 21221505
MH  - Communicable Diseases/*epidemiology
MH  - *Delivery of Health Care/ethics
MH  - *Disease Outbreaks
MH  - Ethics, Professional
MH  - Global Health
MH  - Health Personnel/ethics
MH  - Humans
MH  - Influenza, Human/*diagnosis/*epidemiology
MH  - Moral Obligations
MH  - Professional-Patient Relations
MH  - Public Health
MH  - Singapore
MH  - Workforce
RF  - 41
EDAT- 2010/05/28 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/05/28 06:00
PHST- 2010/05/28 06:00 [entrez]
PHST- 2010/05/28 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
PST - ppublish
SO  - Singapore Med J. 2010 Apr;51(4):275-81.


PMID- 20505849
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1937-5719 (Electronic)
IS  - 1937-5719 (Linking)
VI  - 10
DP  - 2010 May 21
TI  - Endoscope-assisted submandibular sialadenectomy: a review of outcomes,
      complications, and ethical concerns.
PG  - e36
AB  - OBJECTIVES: To review outcomes and complications of endoscope-assisted
      submandibular sialadenectomy (EASS) and to analyze this innovative technique with
      regard to ethical issues. METHODS: We used a systematic review study design to
      identify clinical studies on EASS, published in English, French, German, and
      Thai. The last electronic search was conducted in September 2009. We checked the 
      bibliographies of the identified articles, relevant local journals, and congress 
      abstracts. Publications were further assessed and assigned their respective
      levels of evidence. We also investigated reporting on human subject protection,
      conflicts of interest, funding support, and commercial relationships. RESULTS:
      Five case series reporting a total of 28 patients met the inclusion criteria.
      There was no need of recourse to open surgery. All of the authors claimed
      satisfactory cosmetic results. Complications were uncommon. However, no
      controlled trial was available, and outcome measures varied between studies.
      Human subject protection and funding sources were mentioned in only 2 articles.
      Commercial relationships and conflicts of interest could not be identified.
      CONCLUSIONS: All of the reports favor outcomes of EASS. However, their level of
      evidence is low, and the superiority of this procedure over the conventional
      surgery remains unknown. The success of this procedure should not be
      overemphasized in information for consent and mislead surgeons to begin it
      without adequate training and elaborate environment. The lack of ethical
      documentation creates a high degree of suspicion of the studies.
FAU - Pitak-Arnnop, Poramate
AU  - Pitak-Arnnop P
FAU - Pausch, Niels Christian
AU  - Pausch NC
FAU - Dhanuthai, Kittipong
AU  - Dhanuthai K
FAU - Sappayatosok, Kraison
AU  - Sappayatosok K
FAU - Ngamwannagul, Pichit
AU  - Ngamwannagul P
FAU - Bauer, Ute
AU  - Bauer U
FAU - Sader, Robert
AU  - Sader R
FAU - Rapidis, Alexander D
AU  - Rapidis AD
FAU - Herve, Christian
AU  - Herve C
FAU - Hemprich, Alexander
AU  - Hemprich A
LA  - eng
PT  - Journal Article
DEP - 20100521
PL  - United States
TA  - Eplasty
JT  - Eplasty
JID - 101316107
PMC - PMC2875098
EDAT- 2010/05/28 06:00
MHDA- 2010/05/28 06:01
CRDT- 2010/05/28 06:00
PHST- 2010/05/28 06:00 [entrez]
PHST- 2010/05/28 06:00 [pubmed]
PHST- 2010/05/28 06:01 [medline]
PST - epublish
SO  - Eplasty. 2010 May 21;10:e36.


PMID- 20505754
OWN - NLM
STAT- MEDLINE
DCOM- 20100907
LR  - 20211020
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 5
IP  - 5
DP  - 2010 May 20
TI  - What leads Indians to participate in clinical trials? A meta-analysis of
      qualitative studies.
PG  - e10730
LID - 10.1371/journal.pone.0010730 [doi]
AB  - BACKGROUND: With the globalization of clinical trials, large developing nations
      have substantially increased their participation in multi-site studies. This
      participation has raised ethical concerns, among them the fear that local
      customs, habits and culture are not respected while asking potential participants
      to take part in study. This knowledge gap is particularly noticeable among Indian
      subjects, since despite the large number of participants, little is known
      regarding what factors affect their willingness to participate in clinical
      trials. METHODS: We conducted a meta-analysis of all studies evaluating the
      factors and barriers, from the perspective of potential Indian participants,
      contributing to their participation in clinical trials. We searched both
      international as well as Indian-specific bibliographic databases, including
      Pubmed, Cochrane, Openjgate, MedInd, Scirus and Medknow, also performing hand
      searches and communicating with authors to obtain additional references. We
      enrolled studies dealing exclusively with the participation of Indians in
      clinical trials. Data extraction was conducted by three researchers, with
      disagreement being resolved by consensus. RESULTS: Six qualitative studies and
      one survey were found evaluating the main themes affecting the participation of
      Indian subjects. Themes included Personal health benefits, Altruism, Trust in
      physicians, Source of extra income, Detailed knowledge, Methods for motivating
      participants as factors favoring, while Mistrust on trial organizations, Concerns
      about efficacy and safety of trials, Psychological reasons, Trial burden, Loss of
      confidentiality, Dependency issues, Language as the barriers. CONCLUSION: We
      identified factors that facilitated and barriers that have negative implications 
      on trial participation decisions in Indian subjects. Due consideration and
      weightage should be assigned to these factors while planning future trials in
      India.
FAU - Shah, Jatin Y
AU  - Shah JY
AD  - Graduate Medical School, Duke-National University of Singapore, Singapore,
      Singapore.
FAU - Phadtare, Amruta
AU  - Phadtare A
FAU - Rajgor, Dimple
AU  - Rajgor D
FAU - Vaghasia, Meenakshi
AU  - Vaghasia M
FAU - Pradhan, Shreyasee
AU  - Pradhan S
FAU - Zelko, Hilary
AU  - Zelko H
FAU - Pietrobon, Ricardo
AU  - Pietrobon R
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20100520
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Clinical Trials as Topic/*psychology
MH  - Humans
MH  - India
MH  - Patient Participation/*psychology
MH  - Publications
MH  - Reproducibility of Results
PMC - PMC2873955
EDAT- 2010/05/28 06:00
MHDA- 2010/09/08 06:00
CRDT- 2010/05/28 06:00
PHST- 2009/09/02 00:00 [received]
PHST- 2010/04/05 00:00 [accepted]
PHST- 2010/05/28 06:00 [entrez]
PHST- 2010/05/28 06:00 [pubmed]
PHST- 2010/09/08 06:00 [medline]
AID - 10.1371/journal.pone.0010730 [doi]
PST - epublish
SO  - PLoS One. 2010 May 20;5(5):e10730. doi: 10.1371/journal.pone.0010730.


PMID- 20505579
OWN - NLM
STAT- MEDLINE
DCOM- 20110914
LR  - 20141120
IS  - 0966-0461 (Print)
IS  - 0966-0461 (Linking)
VI  - 19
IP  - 9
DP  - 2010 May 13-26
TI  - The imperative of human obesity: an ethical reflection.
PG  - 563-8
AB  - Good health for all has become an accepted international goal. Arguably there
      have been broad gains in life expectancy over the past century. However, the
      escalating epidemic of adult obesity, estimated at more than 1 billion worldwide,
      has become a major public health concern. Obesity affects people of all ages and 
      socioeconomic backgrounds. It is invariably perceived as a product of biological,
      psychological and social conditions, thereby casting aside its ethical
      imperatives. Without undermining the role of medicine in managing obesity, this
      article proposes to discuss the need for nurses to consider relevant ethical
      principles when supporting people with obesity.
FAU - Meetoo, Danny
AU  - Meetoo D
AD  - School of Nursing and Midwifery, University of Salford, UK.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Nurs
JT  - British journal of nursing (Mark Allen Publishing)
JID - 9212059
MH  - *Ethics, Nursing
MH  - Global Health
MH  - Health Promotion/*ethics
MH  - Humans
MH  - *Obesity/epidemiology/nursing/psychology
MH  - *Social Support
EDAT- 2010/05/28 06:00
MHDA- 2011/09/15 06:00
CRDT- 2010/05/28 06:00
PHST- 2010/05/28 06:00 [entrez]
PHST- 2010/05/28 06:00 [pubmed]
PHST- 2011/09/15 06:00 [medline]
AID - 10.12968/bjon.2010.19.9.48055 [doi]
PST - ppublish
SO  - Br J Nurs. 2010 May 13-26;19(9):563-8. doi: 10.12968/bjon.2010.19.9.48055.


PMID- 20505529
OWN - NLM
STAT- MEDLINE
DCOM- 20101026
LR  - 20201209
IS  - 1539-2031 (Electronic)
IS  - 0192-0790 (Linking)
VI  - 44
IP  - 7
DP  - 2010 Aug
TI  - Sequential therapy for Helicobacter pylori infection: ethical considerations
      revisited.
PG  - 523
LID - 10.1097/MCG.0b013e3181e00566 [doi]
FAU - Graham, David Y
AU  - Graham DY
FAU - Fischbach, Lori
AU  - Fischbach L
LA  - eng
GR  - DK56338/DK/NIDDK NIH HHS/United States
GR  - R01 CA116845/CA/NCI NIH HHS/United States
PT  - Letter
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Comment
PL  - United States
TA  - J Clin Gastroenterol
JT  - Journal of clinical gastroenterology
JID - 7910017
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Anti-Ulcer Agents)
SB  - IM
CON - J Clin Gastroenterol. 2010 Apr;44(4):261-6. PMID: 20195162
MH  - Anti-Bacterial Agents/administration & dosage/*therapeutic use
MH  - Anti-Ulcer Agents/administration & dosage/therapeutic use
MH  - Clinical Trials as Topic
MH  - Drug Therapy, Combination
MH  - Helicobacter Infections/*drug therapy
MH  - Helicobacter pylori/drug effects
MH  - Humans
MH  - Italy
MH  - Practice Patterns, Physicians'/*ethics
EDAT- 2010/05/28 06:00
MHDA- 2010/10/27 06:00
CRDT- 2010/05/28 06:00
PHST- 2010/05/28 06:00 [entrez]
PHST- 2010/05/28 06:00 [pubmed]
PHST- 2010/10/27 06:00 [medline]
AID - 10.1097/MCG.0b013e3181e00566 [doi]
PST - ppublish
SO  - J Clin Gastroenterol. 2010 Aug;44(7):523. doi: 10.1097/MCG.0b013e3181e00566.


PMID- 20505480
OWN - NLM
STAT- MEDLINE
DCOM- 20100910
LR  - 20100527
IS  - 1539-073X (Electronic)
IS  - 1520-9229 (Linking)
VI  - 12
IP  - 2
DP  - 2010 Apr-Jun
TI  - An evaluation of unit-based ethics conversations.
PG  - 48-54; quiz 55-6
LID - 10.1097/NHL.0b013e3181de18a2 [doi]
AB  - Unit-based ethics conversations (UBECs) provide nurses with an opportunity for
      meaningful conversation about the ethical issues they face in routine clinical
      practice. The goal of the program is to increase participants' abilities and
      confidence in dealing with ethically challenging situations. This article reviews
      results from a formal evaluation of UBECs at one organization. The results of
      this evaluation suggest the UBEC program provides a transformational ethics
      experience for nurses.
FAU - Wocial, Lucia D
AU  - Wocial LD
AD  - Charles Warren Fairbanks Center for Medical Ethics and Clarian Health, Indiana
      University School of Nursing, Indianapolis, IN 46202, USA. lwocial@clarian.org
FAU - Hancock, Maureen
AU  - Hancock M
FAU - Bledsoe, Patricia D
AU  - Bledsoe PD
FAU - Chamness, Amy R
AU  - Chamness AR
FAU - Helft, Paul R
AU  - Helft PR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - JONAS Healthc Law Ethics Regul
JT  - JONA'S healthcare law, ethics and regulation
JID - 100888423
MH  - Adult
MH  - Ethics, Nursing/*education
MH  - Female
MH  - Focus Groups
MH  - Humans
MH  - Indiana
MH  - Inservice Training/*methods
MH  - Male
MH  - Middle Aged
MH  - Nursing Service, Hospital/*ethics
MH  - Organizational Case Studies
MH  - *Organizational Culture
MH  - Program Evaluation
MH  - Young Adult
EDAT- 2010/05/28 06:00
MHDA- 2010/09/11 06:00
CRDT- 2010/05/28 06:00
PHST- 2010/05/28 06:00 [entrez]
PHST- 2010/05/28 06:00 [pubmed]
PHST- 2010/09/11 06:00 [medline]
AID - 10.1097/NHL.0b013e3181de18a2 [doi]
AID - 00128488-201004000-00005 [pii]
PST - ppublish
SO  - JONAS Healthc Law Ethics Regul. 2010 Apr-Jun;12(2):48-54; quiz 55-6. doi:
      10.1097/NHL.0b013e3181de18a2.


PMID- 20505479
OWN - NLM
STAT- MEDLINE
DCOM- 20100910
LR  - 20100527
IS  - 1539-073X (Electronic)
IS  - 1520-9229 (Linking)
VI  - 12
IP  - 2
DP  - 2010 Apr-Jun
TI  - Does good documentation equate to good nursing care?
PG  - 43-7
LID - 10.1097/NHL.0b013e3181e05ee7 [doi]
AB  - Good documentation does not necessarily equate to good care. This article
      explores the potential underpinnings of poor documentation from an ethical
      decision-making lens. Nursing standards of care related to documentation are
      reviewed. The internal and external constraints of moral distress are considered,
      as is moral residue. Finally, the roles of the nurse administrator as well as
      specific remedial and restorative measures are suggested.
FAU - Bosek, Marcia Sue DeWolf
AU  - Bosek MS
AD  - Department of Nursing, University of Vermont, Burlington, VT, USA.
      marcia.bosek@umv.edu
FAU - Ring, Marcia Ellen
AU  - Ring ME
LA  - eng
PT  - Journal Article
PL  - United States
TA  - JONAS Healthc Law Ethics Regul
JT  - JONA'S healthcare law, ethics and regulation
JID - 100888423
MH  - Documentation/ethics/*standards
MH  - Ethics, Nursing
MH  - Humans
MH  - Medical Records/*standards
MH  - Nursing Care/ethics/*standards
MH  - Nursing Process/ethics/standards
MH  - United States
EDAT- 2010/05/28 06:00
MHDA- 2010/09/11 06:00
CRDT- 2010/05/28 06:00
PHST- 2010/05/28 06:00 [entrez]
PHST- 2010/05/28 06:00 [pubmed]
PHST- 2010/09/11 06:00 [medline]
AID - 10.1097/NHL.0b013e3181e05ee7 [doi]
AID - 00128488-201004000-00004 [pii]
PST - ppublish
SO  - JONAS Healthc Law Ethics Regul. 2010 Apr-Jun;12(2):43-7. doi:
      10.1097/NHL.0b013e3181e05ee7.


PMID- 20505425
OWN - NLM
STAT- MEDLINE
DCOM- 20100826
LR  - 20220409
IS  - 1536-0911 (Electronic)
IS  - 1536-0903 (Linking)
VI  - 10
IP  - 3
DP  - 2010 Jun
TI  - Moral distress in neonatal intensive care unit RNs.
PG  - 145-56
LID - 10.1097/ANC.0b013e3181dd6c48 [doi]
AB  - BACKGROUND: Moral distress is a significant problem for nurses (RNs). It has
      physical, emotional, and psychological sequelae and a negative impact on the
      quality, quantity, and cost of patient care. Moral distress leads to loss of
      moral integrity and job dissatisfaction and is a major cause of burnout and RNs
      leaving the profession. The majority of research has been carried out with RNs
      working in acute care, adult inpatient settings, especially critical care areas. 
      Neonatal intensive care unit (NICU) RNs confront ethically and morally
      challenging situations on a regular basis. There are limited data clarifying
      their moral distress. AIMS: The purpose of this study was to describe the moral
      distress of RNs working in NICUs and to identify the situations that are
      associated with their moral distress. RESEARCH QUESTIONS: What are the intensity 
      and frequency of moral distress in NICU RNs, what situations are associated with 
      moral distress in NICU RNs, and what personal characteristics are correlated with
      moral distress in NICU RNs? DESIGN AND METHODS: This descriptive, correlational
      study was conducted with RNs in the level III NICUs of a healthcare system in the
      northeastern United States. Participation was voluntary and anonymous. A
      convenience sample of RNs completed a demographic data sheet and the Moral
      Distress Scale Neonatal-Pediatric Version. Data were collected during October
      2008. Ninety-four of 196 eligible RNs (48%) participated in the study. FINDINGS: 
      As a whole, the subjects did not perceive that the situations described in the
      instrument occurred frequently and did not cause great distress. Subjects'
      individual scores displayed wide variations for all dimensions of moral distress 
      ranging from low to high, indicating that individual RNs may be experiencing
      moral distress.The situations receiving the highest scores are comparable with
      the areas that are problematic for other critical care nurses as described in the
      literature. In this study, 4 RN characteristics were significantly related to
      moral distress: the desire to leave their current position, lack of spirituality,
      altered approach to patient care, and considering but not leaving a previous job 
      because of moral distress. CONCLUSIONS: The results of this study add to the
      understanding of the moral distress in NICU RNs. The data will provide evidence
      for eventual psychometric testing and factor analysis of the Moral Distress Scale
      Neonatal-Pediatric Version.
FAU - Cavaliere, Terri A
AU  - Cavaliere TA
AD  - Schneider Children's Hospital at North Shore, Manhasset, NY, USA.
      tcavalie@nshs.edu
FAU - Daly, Barbara
AU  - Daly B
FAU - Dowling, Donna
AU  - Dowling D
FAU - Montgomery, Kathleen
AU  - Montgomery K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Adv Neonatal Care
JT  - Advances in neonatal care : official journal of the National Association of
      Neonatal Nurses
JID - 101125644
SB  - IM
MH  - Adaptation, Psychological
MH  - Adult
MH  - Analysis of Variance
MH  - *Attitude of Health Personnel
MH  - Burnout, Professional/diagnosis/*psychology
MH  - Conflict, Psychological
MH  - Dissent and Disputes
MH  - Female
MH  - Humans
MH  - Intensive Care Units, Neonatal/*ethics/organization & administration
MH  - Job Satisfaction
MH  - Male
MH  - Middle Aged
MH  - *Morals
MH  - Neonatal Nursing/*ethics/organization & administration
MH  - New England
MH  - Nursing Methodology Research
MH  - *Nursing Staff, Hospital/ethics/psychology
MH  - Personnel Turnover
MH  - Risk Factors
MH  - Spirituality
MH  - Surveys and Questionnaires
EDAT- 2010/05/28 06:00
MHDA- 2010/08/27 06:00
CRDT- 2010/05/28 06:00
PHST- 2010/05/28 06:00 [entrez]
PHST- 2010/05/28 06:00 [pubmed]
PHST- 2010/08/27 06:00 [medline]
AID - 10.1097/ANC.0b013e3181dd6c48 [doi]
AID - 00149525-201006000-00010 [pii]
PST - ppublish
SO  - Adv Neonatal Care. 2010 Jun;10(3):145-56. doi: 10.1097/ANC.0b013e3181dd6c48.


PMID- 20505406
OWN - NLM
STAT- MEDLINE
DCOM- 20100618
LR  - 20100603
IS  - 1938-808X (Electronic)
IS  - 1040-2446 (Linking)
VI  - 85
IP  - 6
DP  - 2010 Jun
TI  - Integrating bioethics into postgraduate medical education: the University of
      Toronto model.
PG  - 1035-40
LID - 10.1097/ACM.0b013e3181dbebb8 [doi]
AB  - Bioethics training is a vital component of postgraduate medical education and
      required by accreditation organizations in Canada and the United States.
      Residency program ethics curricula should ensure trainees develop core knowledge,
      skills, and competencies, and should encourage lifelong learning and teaching of 
      bioethics. Many physician-teachers, however, feel unprepared to teach bioethics
      and face challenges in developing and implementing specialty-specific bioethics
      curricula. The authors present, as one model, the innovative strategies employed 
      by the University of Toronto Joint Centre for Bioethics. They postulate that
      centralized support is a key component to ensure the success of
      specialty-specific bioethics teaching, to reinforce the importance of ethics in
      medical training, and to ensure it is not overshadowed by other educational
      concerns.
FAU - Howard, Frazer
AU  - Howard F
AD  - University of Toronto Joint Centre for Bioethics, Toronto, Ontario, Canada.
FAU - McKneally, Martin F
AU  - McKneally MF
FAU - Levin, Alex V
AU  - Levin AV
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Acad Med
JT  - Academic medicine : journal of the Association of American Medical Colleges
JID - 8904605
SB  - IM
MH  - Bioethics/*education
MH  - *Education, Medical, Graduate
MH  - Faculty, Medical
MH  - Internet
MH  - Internship and Residency
MH  - Models, Educational
MH  - Ontario
MH  - Research
EDAT- 2010/05/28 06:00
MHDA- 2010/06/19 06:00
CRDT- 2010/05/28 06:00
PHST- 2010/05/28 06:00 [entrez]
PHST- 2010/05/28 06:00 [pubmed]
PHST- 2010/06/19 06:00 [medline]
AID - 10.1097/ACM.0b013e3181dbebb8 [doi]
PST - ppublish
SO  - Acad Med. 2010 Jun;85(6):1035-40. doi: 10.1097/ACM.0b013e3181dbebb8.


PMID- 20505394
OWN - NLM
STAT- MEDLINE
DCOM- 20100618
LR  - 20181201
IS  - 1938-808X (Electronic)
IS  - 1040-2446 (Linking)
VI  - 85
IP  - 6
DP  - 2010 Jun
TI  - Academic retainer medicine: an innovative business model for cross-subsidizing
      primary care.
PG  - 959-64
LID - 10.1097/ACM.0b013e3181dbe19e [doi]
AB  - Retainer-medicine primary care practices, commonly referred to as "luxury" or
      "concierge" practices, provide enhanced services to patients beyond those
      available in traditional practices for a yearly retainer fee. Adoption of
      retainer practices has been largely absent in academic health centers (AHCs).
      Reasons for this trend stem primarily from ethical concerns, such as the
      potential for patient abandonment when physicians downsize from larger,
      traditional practices to smaller, retainer-medicine practices.In 2004, the
      Department of Medicine at Tufts Medical Center developed an academic
      retainer-medicine primary care practice within the Division of General Medicine
      that not only generates financial support for the division but also incorporates 
      a clinical and business model that is aligned with the mission and ethics of an
      academic institution.In contrast to private retainer-medicine practices, this
      unique business model addresses several of the ethical issues associated with
      traditional retainer practices-it does not restrict net access to care and it
      neutralizes concerns about patient abandonment. Addressing the growing primary
      care shortage, the model also presents the opportunity for a retainer practice to
      cross-subsidize the expansion of general medicine in an academic medical setting.
      The authors elucidate the benefits, as well as the inherent challenges, of
      embedding an academic retainer-medicine practice within an AHC.
FAU - Lucier, David J
AU  - Lucier DJ
AD  - Tufts University School of Medicine, Boston, MA, USA.
FAU - Frisch, Nicholas B
AU  - Frisch NB
FAU - Cohen, Brian J
AU  - Cohen BJ
FAU - Wagner, Michael
AU  - Wagner M
FAU - Salem, Deeb
AU  - Salem D
FAU - Fairchild, David G
AU  - Fairchild DG
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Acad Med
JT  - Academic medicine : journal of the Association of American Medical Colleges
JID - 8904605
SB  - IM
MH  - Ethics, Medical
MH  - Massachusetts
MH  - Models, Economic
MH  - Physician's Role
MH  - Primary Health Care/*economics/statistics & numerical data
MH  - Schools, Medical/*economics
EDAT- 2010/05/28 06:00
MHDA- 2010/06/19 06:00
CRDT- 2010/05/28 06:00
PHST- 2010/05/28 06:00 [entrez]
PHST- 2010/05/28 06:00 [pubmed]
PHST- 2010/06/19 06:00 [medline]
AID - 10.1097/ACM.0b013e3181dbe19e [doi]
PST - ppublish
SO  - Acad Med. 2010 Jun;85(6):959-64. doi: 10.1097/ACM.0b013e3181dbe19e.


PMID- 20505069
OWN - NLM
STAT- MEDLINE
DCOM- 20100716
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 256
IP  - 1
DP  - 2010 Jul
TI  - Resting-state perfusion in nonmedicated schizophrenic patients: a continuous
      arterial spin-labeling 3.0-T MR study.
PG  - 253-60
LID - 10.1148/radiol.10091224 [doi]
AB  - PURPOSE: To determine whether well-described patterns of altered perfusion in
      schizophrenia can be identified by using continuous arterial spin labeling (CASL)
      with a whole-brain imaging sequence. MATERIALS AND METHODS: This study was
      approved by the ethics committee of the local institutional review board, and
      written informed consent was obtained from all subjects. CASL was used to compare
      cerebral perfusion between 11 nonmedicated patients with schizophrenia and 25
      healthy control subjects. Since antipsychotic medication may affect perfusion,
      only drug-free subjects were examined. Resting-state perfusion, as measured in
      terms of regional cerebral blood flow, was compared voxel wise by using an
      analysis of variance design in a statistical parametric mapping program, with
      patient age and sex as covariates. RESULTS: Compared with the healthy control
      subjects, the schizophrenic patients had extensive areas of hypoperfusion in the 
      frontal lobes bilaterally, in the anterior and medial cingulate gyri, and in the 
      parietal lobes bilaterally. Increased perfusion was observed in the cerebellum,
      brainstem, and thalamus of the schizophrenic patients as compared with the
      perfusion in these areas in the control subjects. CONCLUSION: CASL in
      schizophrenia revealed patterns of hypo- and hyperperfusion similar to the
      perfusion patterns in previously published positron emission tomographic and
      single photon emission computed tomographic studies. The advantages of CASL,
      including independence from injected contrast agents, no irradiation, and fast
      acquisition time, may facilitate intensive perfusion studies of the early
      recognition of schizophrenia and other psychiatric disorders, as well as
      longitudinal disease-monitoring research of these conditions.
FAU - Scheef, Lukas
AU  - Scheef L
AD  - Department of Radiology, University of Bonn, Sigmund Freud-Str 25, Bonn, Germany.
      Lukas.Scheef@ukb.uni-bonn.de
FAU - Manka, Christoph
AU  - Manka C
FAU - Daamen, Marcel
AU  - Daamen M
FAU - Kuhn, Kai-Uwe
AU  - Kuhn KU
FAU - Maier, Wolfgang
AU  - Maier W
FAU - Schild, Hans H
AU  - Schild HH
FAU - Jessen, Frank
AU  - Jessen F
LA  - eng
PT  - Journal Article
DEP - 20100526
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Spin Labels)
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Brain/*blood supply/diagnostic imaging
MH  - Brain Mapping
MH  - Case-Control Studies
MH  - Cerebrovascular Circulation/physiology
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Positron-Emission Tomography
MH  - Prospective Studies
MH  - Rest
MH  - Schizophrenia/diagnostic imaging/*physiopathology
MH  - *Spin Labels
MH  - Tomography, Emission-Computed, Single-Photon
EDAT- 2010/05/28 06:00
MHDA- 2010/07/17 06:00
CRDT- 2010/05/28 06:00
PHST- 2010/05/28 06:00 [entrez]
PHST- 2010/05/28 06:00 [pubmed]
PHST- 2010/07/17 06:00 [medline]
AID - radiol.10091224 [pii]
AID - 10.1148/radiol.10091224 [doi]
PST - ppublish
SO  - Radiology. 2010 Jul;256(1):253-60. doi: 10.1148/radiol.10091224. Epub 2010 May
      26.


PMID- 20505063
OWN - NLM
STAT- MEDLINE
DCOM- 20100716
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 256
IP  - 1
DP  - 2010 Jul
TI  - Intracranial aneurysms treated with coil placement: test characteristics of
      follow-up MR angiography--multicenter study.
PG  - 209-18
LID - 10.1148/radiol.10091528 [doi]
AB  - PURPOSE: To determine the test characteristics of magnetic resonance (MR)
      angiography in the assessment of occlusion of aneurysms treated with coil
      placement. MATERIALS AND METHODS: This was an ethics committee-approved
      multicenter study. written informed consent was obtained in 311 patients with 343
      aneurysms, who had been treated with coil placement and were scheduled for
      routine follow-up with intraarterial digital subtraction angiography (DSA).
      Thirty-five patients participated two or three times. Either 3.0- or 1.5-T
      time-of-flight (TOF) and contrast material-enhanced MR angiography were performed
      in addition to intraarterial DSA. Aneurysm occlusion was evaluated by independent
      readers at DSA and MR angiography. The test characteristics of MR angiography
      were assessed by using DSA as the standard. The area under the receiver operating
      characteristic curve (AUC) was calculated for 3.0- versus 1.5-T MR angiography
      and for TOF versus contrast-enhanced MR angiography, and factors associated with 
      discrepancies between MR angiography and DSA were assessed with logistic
      regression. RESULTS: Aneurysm assessments (n = 381) at DSA and MR angiography
      were compared. Incomplete occlusion was seen at DSA in 88 aneurysms (23%).
      Negative predictive value of MR angiography was 94% (95% confidence interval
      [CI]: 91%, 97%), positive predictive value was 69% (95% CI: 60%, 78%),
      sensitivity was 82% (95% CI: 72%, 89%), and specificity was 89% (95% CI: 85%,
      93%). AUCs were similar for 3.0- (0.90 [95% CI: 0.86, 0.94]) and 1.5-T MR (0.87
      [95% CI: 0.78, 0.95]) and for TOF MR (0.86 [95% CI: 0.81, 0.91]) versus
      contrast-enhanced MR (0.85 [95% CI: 0.80, 0.91]). A small residual lumen (odds
      ratio, 2.1 [95% CI: 1.1, 4.3]) and suboptimal projection at DSA (odds ratio, 5.5 
      [95% CI: 1.5, 21.0]) were independently associated with discordance between
      intraarterial DSA and MR angiography. CONCLUSION: Documentation of good
      diagnostic performance of TOF MR angiography at both 1.5 and 3.0 T in the current
      study represents an important step toward replacing intraarterial DSA with MR
      angiography in the follow-up of patients with aneurysms treated with coils.
FAU - Schaafsma, Joanna D
AU  - Schaafsma JD
AD  - Department of Neurology, Rudolf Magnus Institute of Neuroscience, University
      Medical Center Utrecht, Utrecht, the Netherlands. j.d.schaafsma@umcutrecht.nl
FAU - Velthuis, Birgitta K
AU  - Velthuis BK
FAU - Majoie, Charles B L M
AU  - Majoie CB
FAU - van den Berg, Rene
AU  - van den Berg R
FAU - Brouwer, Patrick A
AU  - Brouwer PA
FAU - Barkhof, Frederik
AU  - Barkhof F
FAU - Eshghi, Omid
AU  - Eshghi O
FAU - de Kort, Gerard A P
AU  - de Kort GA
FAU - Lo, Rob T H
AU  - Lo RT
FAU - Witkamp, Theo D
AU  - Witkamp TD
FAU - Sprengers, Marieke E S
AU  - Sprengers ME
FAU - van Walderveen, Marianne A
AU  - van Walderveen MA
FAU - Bot, Joseph C
AU  - Bot JC
FAU - Sanchez, Esther
AU  - Sanchez E
FAU - Vandertop, W Peter
AU  - Vandertop WP
FAU - van Gijn, Jan
AU  - van Gijn J
FAU - Buskens, Erik
AU  - Buskens E
FAU - van der Graaf, Yolanda
AU  - van der Graaf Y
FAU - Rinkel, Gabriel J E
AU  - Rinkel GJ
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20100526
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - 0 (Triiodobenzoic Acids)
RN  - HW8W27HTXX (iodixanol)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Angiography, Digital Subtraction
MH  - Area Under Curve
MH  - Cerebral Angiography/*methods
MH  - Contrast Media
MH  - *Embolization, Therapeutic
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Intracranial Aneurysm/*diagnosis/*therapy
MH  - Logistic Models
MH  - Magnetic Resonance Angiography/*methods
MH  - Male
MH  - Middle Aged
MH  - Netherlands
MH  - Predictive Value of Tests
MH  - ROC Curve
MH  - Treatment Outcome
MH  - Triiodobenzoic Acids
EDAT- 2010/05/28 06:00
MHDA- 2010/07/17 06:00
CRDT- 2010/05/28 06:00
PHST- 2010/05/28 06:00 [entrez]
PHST- 2010/05/28 06:00 [pubmed]
PHST- 2010/07/17 06:00 [medline]
AID - radiol.10091528 [pii]
AID - 10.1148/radiol.10091528 [doi]
PST - ppublish
SO  - Radiology. 2010 Jul;256(1):209-18. doi: 10.1148/radiol.10091528. Epub 2010 May
      26.


PMID- 20505061
OWN - NLM
STAT- MEDLINE
DCOM- 20100716
LR  - 20151119
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 256
IP  - 1
DP  - 2010 Jul
TI  - Effect of anesthesia and sedation on pediatric MR imaging patient flow.
PG  - 229-37
LID - 10.1148/radiol.10091124 [doi]
AB  - PURPOSE: To determine the effect of sedative and anesthetic administration on the
      duration and costs of pediatric magnetic resonance (MR) imaging. MATERIALS AND
      METHODS: This prospective study was approved by the institutional research ethics
      board; informed consent and/or assent was obtained from all participants or their
      parents. A patient flow study was conducted in a pediatric MR imaging clinic in
      which research assistants tracked participants' progress through the clinic.
      Demographic, visit process, and medication information was collected for 237
      participants, categorized as awake, sedated, or anesthetized. The data were
      analyzed to (a) determine total visit duration differences, (b) investigate
      variations in visit stage durations according to patient type, and (c) estimate
      visit costs on the basis of human resource and medication use. Linear regression,
      the Shapiro-Wilk test, the two-tailed t test, and the nonparametric Mann-Whitney 
      test were used. RESULTS: Complete data sets were obtained for 148 awake, 28
      sedated, and 27 anesthetized participants. Data revealed 12 stage sequences among
      patient visits; dominant sequences differed according to patient category. An
      awake patient's average visit duration (2 hours 21 minutes) differed
      significantly from that of sedated (3 hours 38 minutes, P < .001) and
      anesthetized (4 hours 7 minutes, P < .001) patients; sedated and anesthetized
      visit durations did not differ significantly (P < .073), although this finding
      may be attributable to the small sample sizes. Variation in stage durations was
      also evident within and among patient types. Visit costs for sedated and
      anesthetized patients were 3.24 and 9.56 times higher, respectively, than those
      for awake patients. Costs for anesthetized patients were 2.95 times higher than
      those for sedated patients. CONCLUSION: Visit durations were significantly longer
      for anesthetized and sedated patients. Anesthetized patients incurred the highest
      costs, followed by sedated patients.
FAU - Vanderby, Sonya A
AU  - Vanderby SA
AD  - Department of Mechanical and Industrial Engineering, University of Toronto,
      Toronto, ON, Canada. s.vanderby@utoronto.ca
FAU - Babyn, Paul S
AU  - Babyn PS
FAU - Carter, Michael W
AU  - Carter MW
FAU - Jewell, Susan M
AU  - Jewell SM
FAU - McKeever, Patricia D
AU  - McKeever PD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100526
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
SB  - IM
MH  - Anesthesia/*economics/*methods
MH  - Child
MH  - Conscious Sedation/*economics/*methods
MH  - Contrast Media/economics
MH  - Costs and Cost Analysis
MH  - Female
MH  - Humans
MH  - Linear Models
MH  - Magnetic Resonance Imaging/*economics/*methods
MH  - Male
MH  - Prospective Studies
MH  - Statistics, Nonparametric
EDAT- 2010/05/28 06:00
MHDA- 2010/07/17 06:00
CRDT- 2010/05/28 06:00
PHST- 2010/05/28 06:00 [entrez]
PHST- 2010/05/28 06:00 [pubmed]
PHST- 2010/07/17 06:00 [medline]
AID - radiol.10091124 [pii]
AID - 10.1148/radiol.10091124 [doi]
PST - ppublish
SO  - Radiology. 2010 Jul;256(1):229-37. doi: 10.1148/radiol.10091124. Epub 2010 May
      26.


PMID- 20504782
OWN - NLM
STAT- MEDLINE
DCOM- 20100929
LR  - 20101007
IS  - 1553-3514 (Electronic)
IS  - 1553-3506 (Linking)
VI  - 17
IP  - 2
DP  - 2010 Jun
TI  - Healing of iatrogenic skeletal muscle wounds is affected by incision device.
PG  - 85-91
LID - 10.1177/1553350610364531 [doi]
AB  - Orthopedic joint procedures frequently require extensive dissection of skeletal
      muscles resulting in tissue injury, formation of scar tissue, pain, and
      potentially, functional impairment. The authors hypothesized that using a
      low-temperature ultrasonic cutting and coagulating device (Harmonic Blade,
      Ethicon Endo-Surgery, Cincinnati, OH) would result in reduction in tissue trauma 
      in terms of reducing acute and chronic inflammation during healing. Bilateral
      longitudinal incisions were made into the tibialis cranialis muscles of rabbits
      with either a Harmonic Blade or a standard monopolar electrosurgical scalpel. At 
      3, 7, and 21 days postoperatively, necropsy and histological evaluations
      indicated a significant attenuation of acute inflammation (P = .011) for the
      Harmonic incisions compared with electrosurgery. No significant differences were 
      observed for chronic inflammation, necrosis, or fibrosis. Use of a Harmonic
      scalpel during dissection of skeletal muscle in orthopedic surgery may result in 
      reduced influx of neutrophils, reducing acute inflammation, and potentially aid
      in reducing postoperative pain and functional impairment.
FAU - Rubino, L Joseph
AU  - Rubino LJ
AD  - Wright State University, Dayton, OH, USA.
FAU - Konstantakos, Emmanuel K
AU  - Konstantakos EK
FAU - Stills, Harold F Jr
AU  - Stills HF Jr
FAU - Dudley, Emily S
AU  - Dudley ES
FAU - Grunden, Beverly K
AU  - Grunden BK
FAU - Malaviya, Prasanna
AU  - Malaviya P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Surg Innov
JT  - Surgical innovation
JID - 101233809
SB  - IM
EIN - Surg Innov. 2010 Sep;17(3):277
MH  - Animals
MH  - Dissection/instrumentation
MH  - Female
MH  - Models, Animal
MH  - Muscle, Skeletal/*pathology/*physiology
MH  - Orthopedic Procedures/*instrumentation
MH  - Rabbits
MH  - Ultrasonic Therapy/*instrumentation
MH  - Wound Healing
EDAT- 2010/05/28 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/05/28 06:00
PHST- 2010/05/28 06:00 [entrez]
PHST- 2010/05/28 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - 1553350610364531 [pii]
AID - 10.1177/1553350610364531 [doi]
PST - ppublish
SO  - Surg Innov. 2010 Jun;17(2):85-91. doi: 10.1177/1553350610364531.


PMID- 20482687
OWN - NLM
STAT- MEDLINE
DCOM- 20101014
LR  - 20100520
IS  - 1610-0387 (Electronic)
IS  - 1610-0379 (Linking)
VI  - 8 Suppl 1
DP  - 2010 Mar
TI  - [Pharmacoeconomy in acne--evaluation of benefit and economics].
PG  - S105-14
LID - 10.1111/j.1610-0387.2009.07175.x [doi]
AB  - INTRODUCTION: Acne belongs to the most common skin diseases and has a prevalence 
      in the adolescence of nearly 100% and in adults of about 4%. The quality of life 
      indes is significantly reduced und has impact on daily activities and social life
      and physical and psychological well being as well. The socioeconomic relevance is
      based not only on its prevalence but on direct and indirect costs. For acne
      therapy the knowledge on therapeutic costs is of importance but the cost benefit 
      ratio as well. GOAL: Evidence of therapeutic costs in acne and economic benefit
      of the therapy. METHODS: Systematic review of Cochrane data. RESULTS:
      Calculations reveal general costs of acne treatment in Germany over 400 Mill.Euro
      per year. For the treatment with topical retinoids, BPO and antibiotics as well
      as systemic drugs only a few studies on costeffectiveness are available. For
      topical treatments results are not conclusive and dependent on the different
      health systems. New topical combinations may have a better economic outcome,
      however, more studies are needed. With regard to systemic therapies of moderate
      to severe acne based on the international references the costbenefit ratio
      favours the treatment with oral isotretinoin on the longterm outcome. Superiority
      is based on the relationship of costs and clinical outcome and the increased
      quality of life as well (cost-benefit ratio). It has to be emphazised that only
      longterm observations over years will lead to a valid calculation of costs and
      benefit. FACIT: Taking the high social and quality of life impact into
      consideration an early, well targeted and effective therapy is prevailing.
      Initial higher cost are balanced by a high quality of outcome under experienced
      dermatological supervision. The patients benefit is ranked over the final costs
      because of its medical, social and ethical aspects. To sample more differentiated
      data on pharmacoeconomic aspects well designed new clinical studies are to be set
      up.
FAU - Radtke, Marc A
AU  - Radtke MA
AD  - Universitatsklinikum Hamburg-Eppendorf, Klinik und Poliklinik fur Dermatologie
      und Venerologie, Hamburg Competenzzentrum Versorgungsforschung in der
      Dermatologie CVderm. m.radtke@uke.uni-hamburg.de
FAU - Schafer, Ines
AU  - Schafer I
FAU - Augustin, Matthias
AU  - Augustin M
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Pharmakookonomie der Akne--Bewertung von Nutzen und Wirtschaftlichkeit.
PL  - Germany
TA  - J Dtsch Dermatol Ges
JT  - Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German
      Society of Dermatology : JDDG
JID - 101164708
SB  - IM
MH  - Acne Vulgaris/*drug therapy/*economics/epidemiology/psychology
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Cost-Benefit Analysis
MH  - Cross-Sectional Studies
MH  - Drug Costs/*statistics & numerical data
MH  - Germany
MH  - Humans
MH  - National Health Programs/*economics
MH  - Quality of Life/psychology
MH  - Young Adult
EDAT- 2010/05/28 06:00
MHDA- 2010/10/15 06:00
CRDT- 2010/05/21 06:00
PHST- 2010/05/21 06:00 [entrez]
PHST- 2010/05/28 06:00 [pubmed]
PHST- 2010/10/15 06:00 [medline]
AID - DDG7175 [pii]
AID - 10.1111/j.1610-0387.2009.07175.x [doi]
PST - ppublish
SO  - J Dtsch Dermatol Ges. 2010 Mar;8 Suppl 1:S105-14. doi:
      10.1111/j.1610-0387.2009.07175.x.


PMID- 20470048
OWN - NLM
STAT- MEDLINE
DCOM- 20100607
LR  - 20220317
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Linking)
VI  - 201 Suppl 2
DP  - 2010 Jun 15
TI  - Duration of untreated, uncomplicated Chlamydia trachomatis genital infection and 
      factors associated with chlamydia resolution: a review of human studies.
PG  - S104-13
LID - 10.1086/652402 [doi]
AB  - The majority of Chlamydia trachomatis genital infections in humans are
      asymptomatic and without clinical evidence of complications at the time of
      diagnosis. The natural history of chlamydial infection in humans, including the
      duration of infection and factors influencing resolution of infection, is not yet
      completely understood. This is in part attributable to the inherent challenges
      and ethical considerations in studying untreated chlamydia in humans. An improved
      understanding of the natural history of chlamydia in humans has implications for 
      chlamydia screening and treatment recommendations. In April 2008, the Centers for
      Disease Control and Prevention convened an advisory group for the Chlamydia
      Immunology and Control Expert Advisory Meeting, in which studies related to
      chlamydia natural history, pathogenesis, and immunobiology were reviewed and gaps
      in our knowledge that would have implications for prevention and control of C.
      trachomatis infection were identified. This article summarizes the key questions 
      posed and the evidence reviewed on the duration of untreated, uncomplicated
      genital chlamydial infection in humans and the factors associated with chlamydia 
      resolution.
FAU - Geisler, William M
AU  - Geisler WM
AD  - Department of Medicine, Division of Infectious Diseases, University of Alabama at
      Birmingham, Birmingham, AL 35294-0007, USA. wgeisler@uab.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
SB  - IM
MH  - Chlamydia Infections/genetics/immunology/microbiology/*physiopathology
MH  - Chlamydia trachomatis/*physiology
MH  - Female
MH  - Genital Diseases, Female/genetics/immunology/microbiology/*physiopathology
MH  - Humans
MH  - Risk Factors
MH  - Time Factors
RF  - 30
EDAT- 2010/05/28 06:00
MHDA- 2010/06/09 06:00
CRDT- 2010/05/18 06:00
PHST- 2010/05/18 06:00 [entrez]
PHST- 2010/05/28 06:00 [pubmed]
PHST- 2010/06/09 06:00 [medline]
AID - 10.1086/652402 [doi]
PST - ppublish
SO  - J Infect Dis. 2010 Jun 15;201 Suppl 2:S104-13. doi: 10.1086/652402.


PMID- 20470047
OWN - NLM
STAT- MEDLINE
DCOM- 20100607
LR  - 20100517
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Linking)
VI  - 201 Suppl 2
DP  - 2010 Jun 15
TI  - Duration of untreated chlamydial genital infection and factors associated with
      clearance: review of animal studies.
PG  - S96-103
LID - 10.1086/652393 [doi]
AB  - Chlamydia trachomatis is an important cause of sexually transmitted infection
      that can manifest as acute cervicitis, pelvic inflammatory disease, and most
      commonly, chronic asymptomatic infection. The basis of this wide spectrum of
      manifestations and the factors that lead to clearance or chronic infection are
      poorly understood. We reviewed specific literature pertaining to clearance of
      primary genital tract infections in animal models, including mice, guinea pigs,
      pigs, sheep, and nonhuman primates. T helper 1 cell responses involved in
      cell-mediated immunity are key immune parameters that define efficient clearance 
      in the murine and guinea pig models of chlamydial infection, which are useful for
      studying C. trachomatis clearance. However, there may be some differences between
      humans and other animals in innate and adaptive immune responses to chlamydial
      infection. Studies have suggested that differences in the induced T cell subsets 
      and the species-specific differences in interferon gamma-mediated effector
      mechanisms may play a significant role in these discrepancies. To close these
      gaps in knowledge, translational research in humans is a critical next step.
      However, for questions about specific mechanisms of host-pathogen interaction
      that cannot be answered feasibly or ethically in humans, animal models will
      continue to be important. Future research should include use of humanized and
      nonmurine models that establish prolonged infection to improve understanding of
      chronic human infections.
FAU - Miyairi, Isao
AU  - Miyairi I
AD  - Department of Molecular Sciences and Pediatrics, University of Tennessee Health
      Science Center, Memphis, TN 38163, USA. imiyairi@uthsc.edu
FAU - Ramsey, Kyle H
AU  - Ramsey KH
FAU - Patton, Dorothy L
AU  - Patton DL
LA  - eng
GR  - AI081050/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
SB  - IM
MH  - Adaptive Immunity
MH  - Animals
MH  - Chlamydia Infections/*immunology/*microbiology/physiopathology
MH  - Chlamydia muridarum
MH  - *Chlamydia trachomatis
MH  - Disease Models, Animal
MH  - Female
MH  - Genital Diseases, Female/*immunology/*microbiology/physiopathology
MH  - Humans
MH  - Immunity, Innate
RF  - 86
EDAT- 2010/05/28 06:00
MHDA- 2010/06/09 06:00
CRDT- 2010/05/18 06:00
PHST- 2010/05/18 06:00 [entrez]
PHST- 2010/05/28 06:00 [pubmed]
PHST- 2010/06/09 06:00 [medline]
AID - 10.1086/652393 [doi]
PST - ppublish
SO  - J Infect Dis. 2010 Jun 15;201 Suppl 2:S96-103. doi: 10.1086/652393.


PMID- 20503036
OWN - NLM
STAT- MEDLINE
DCOM- 20111122
LR  - 20211020
IS  - 1433-2965 (Electronic)
IS  - 0937-941X (Linking)
VI  - 22
IP  - 4
DP  - 2011 Apr
TI  - Osteopenia in the maxillofacial area: a study in sheep.
PG  - 1115-21
LID - 10.1007/s00198-010-1289-z [doi]
AB  - UNLABELLED: Osteoporosis is a major public health problem worldwide. Its
      significance in the fields of traumatology and implantology of the maxillofacial 
      area requires investigation. A large animal model was used to assess bone loss in
      the lumbar spine and mandible. INTRODUCTION: Osteoporosis is a prevalent disease 
      characterized by low bone mass and microarchitectural deterioration of bone
      tissue. Osteoporosis-related fractures represent a major public health burden.
      The presence and relevance of osteoporosis in the maxillofacial area remain
      controversial. Research in humans is limited by difficulties in finding large
      homogenous study groups and, due to ethical considerations, numerous animal
      models have been used in osteoporosis research. The aim of this study was to
      assess a sheep model of generalized osteopenia for changes in the maxillofacial
      area. METHODS: Bone loss was induced in ten Merino sheep by ovariectomy,
      intramuscular administration of glucocorticoids, and a calcium-reduced diet. Five
      untreated animals served as controls. Bone mineral density (BMD) was assessed by 
      dual-energy X-ray absorptiometry at the lumbar spine at baseline and after 1, 3, 
      6, 9, and 12 months. Lumbar and mandibular bone biopsies were obtained and
      analyzed with microcomputed tomography. RESULTS: Lumbar BMD decreased
      progressively in the intervention group and was most significantly low after 6
      months (p < 0.001). Lumbar trabecular bone showed a significant decrease in bone 
      volume (BV)/tissue volume (TV; p < 0.05) in the inducted group. Significant
      changes were found in both analyzed mandibular regions for BV/TV (p < 0.05).
      Regional variations were found for other parameters in the mandible. The cortical
      width was substantially reduced in the intervention group (p < 0.001).
      CONCLUSIONS: Microstructural changes occurring in sheep as a result of induction 
      seem to have a generalized nature. This sheep model meets the criteria for
      further investigation in the maxillofacial area.
FAU - Veigel, E
AU  - Veigel E
AD  - Albert-Ludwigs-Universitat, Hugstetterstrasse 55, 79106 Freiburg, Germany.
      egleveigel@gmail.com
FAU - Moore, R J
AU  - Moore RJ
FAU - Zarrinkalam, M R
AU  - Zarrinkalam MR
FAU - Schulze, D
AU  - Schulze D
FAU - Sauerbier, S
AU  - Sauerbier S
FAU - Schmelzeisen, R
AU  - Schmelzeisen R
FAU - Voss, P J
AU  - Voss PJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100526
PL  - England
TA  - Osteoporos Int
JT  - Osteoporosis international : a journal established as result of cooperation
      between the European Foundation for Osteoporosis and the National Osteoporosis
      Foundation of the USA
JID - 9100105
RN  - 0 (Calcium, Dietary)
RN  - 0 (Glucocorticoids)
RN  - 7S5I7G3JQL (Dexamethasone)
SB  - IM
MH  - Animals
MH  - Bone Diseases, Metabolic/diagnostic imaging/*etiology/physiopathology
MH  - Calcium, Dietary/administration & dosage
MH  - Dexamethasone
MH  - *Disease Models, Animal
MH  - Female
MH  - Glucocorticoids
MH  - Lumbar Vertebrae/diagnostic imaging/physiopathology
MH  - Mandible/diagnostic imaging/*physiopathology
MH  - Ovariectomy
MH  - Sheep
MH  - X-Ray Microtomography/methods
EDAT- 2010/05/27 06:00
MHDA- 2011/12/13 00:00
CRDT- 2010/05/27 06:00
PHST- 2009/10/19 00:00 [received]
PHST- 2010/04/09 00:00 [accepted]
PHST- 2010/05/27 06:00 [entrez]
PHST- 2010/05/27 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/s00198-010-1289-z [doi]
PST - ppublish
SO  - Osteoporos Int. 2011 Apr;22(4):1115-21. doi: 10.1007/s00198-010-1289-z. Epub 2010
      May 26.


PMID- 20502382
OWN - NLM
STAT- MEDLINE
DCOM- 20110128
LR  - 20100927
IS  - 1537-4505 (Electronic)
IS  - 1531-7129 (Linking)
VI  - 31
IP  - 8
DP  - 2010 Oct
TI  - Ethical conflicts in caring for patients with cochlear implants.
PG  - 1184-9
LID - 10.1097/MAO.0b013e3181dd15da [doi]
AB  - Although the use of cochlear implants as a treatment designed to help deaf
      individuals hear has a relatively brief history, the use of this therapy has
      given rise to a number of ethical conflicts. This article identifies ethical
      conflicts in cochlear implantation therapy and shows how ethical principles that 
      are commonly accepted in health care ethics may guide decision making in
      resolving these issues. Furthermore, clinicians are often confronted with
      particular cases in which ethical conflicts arise. A useful paradigm for the
      clinical context, the 4-box method, is offered as a means of organizing the facts
      of a "case" so that the important facts are considered, and a principled approach
      to decision making can be used in working toward a resolution.
FAU - McCormick, Thomas R
AU  - McCormick TR
AD  - Department of Bioethics and Humanities, School of Medicine, University of
      Washington, Seattle, Washington 98195-7120, USA. mccormic@uw.edu
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Otol Neurotol
JT  - Otology & neurotology : official publication of the American Otological Society, 
      American Neurotology Society [and] European Academy of Otology and Neurotology
JID - 100961504
SB  - IM
MH  - Cochlear Implantation/*ethics
MH  - Deafness/*surgery
MH  - Decision Making/ethics
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Male
EDAT- 2010/05/27 06:00
MHDA- 2011/02/01 06:00
CRDT- 2010/05/27 06:00
PHST- 2010/05/27 06:00 [entrez]
PHST- 2010/05/27 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
AID - 10.1097/MAO.0b013e3181dd15da [doi]
PST - ppublish
SO  - Otol Neurotol. 2010 Oct;31(8):1184-9. doi: 10.1097/MAO.0b013e3181dd15da.


PMID- 20501980
OWN - NLM
STAT- MEDLINE
DCOM- 20101222
LR  - 20211028
IS  - 1661-5433 (Electronic)
IS  - 1661-5425 (Linking)
VI  - 4
IP  - 4-5
DP  - 2010 Sep
TI  - The European disorder of sex development registry: a virtual research
      environment.
PG  - 192-8
LID - 10.1159/000313434 [doi]
AB  - Disorders of sex development (DSD) are a rare group of conditions which require
      further research. Effective research into understanding the aetiology, as well as
      long-term outcome of these rare conditions, requires multicentre collaboration
      often across national boundaries. The EU-funded EuroDSD programme
      (www.eurodsd.eu) is one such collaboration involving clinical centres and
      clinical and genetic experts across Europe. At the heart of the EuroDSD
      collaboration is a European DSD registry and a targeted virtual research
      environment (VRE) that supports the sharing of DSD data. Security, ethics and
      information governance are cornerstones of this infrastructure. This paper
      describes the infrastructure that has been developed, the inherent challenges in 
      security, availability and dependability that must be overcome for the enterprise
      to succeed and provides a sample of the data that are stored in the registry
      along with a summary analysis of the current data sets.
FAU - Ahmed, S F
AU  - Ahmed SF
AD  - Developmental Endocrinology Research Group, Royal Hospital for Sick Children,
      Glasgow, UK. s.f.ahmed@clinmed.gla.ac.uk
FAU - Rodie, M
AU  - Rodie M
FAU - Jiang, J
AU  - Jiang J
FAU - Sinnott, R O
AU  - Sinnott RO
LA  - eng
GR  - G1100236/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100526
PL  - Switzerland
TA  - Sex Dev
JT  - Sexual development : genetics, molecular biology, evolution, endocrinology,
      embryology, and pathology of sex determination and differentiation
JID - 101316472
SB  - IM
MH  - *Biomedical Research
MH  - Disorders of Sex Development/*epidemiology
MH  - Europe/epidemiology
MH  - Humans
MH  - *Registries
MH  - User-Computer Interface
EDAT- 2010/05/27 06:00
MHDA- 2010/12/24 06:00
CRDT- 2010/05/27 06:00
PHST- 2010/05/27 06:00 [entrez]
PHST- 2010/05/27 06:00 [pubmed]
PHST- 2010/12/24 06:00 [medline]
AID - 000313434 [pii]
AID - 10.1159/000313434 [doi]
PST - ppublish
SO  - Sex Dev. 2010 Sep;4(4-5):192-8. doi: 10.1159/000313434. Epub 2010 May 26.


PMID- 20501734
OWN - NLM
STAT- MEDLINE
DCOM- 20100715
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 255
IP  - 3
DP  - 2010 Jun
TI  - Primary bone malignancy: effective treatment with high-intensity focused
      ultrasound ablation.
PG  - 967-78
LID - 10.1148/radiol.10090374 [doi]
AB  - PURPOSE: To evaluate the long-term follow-up results of ultrasonographically
      (US)-guided high-intensity focused ultrasound ablation in patients with primary
      bone malignancy. MATERIALS AND METHODS: The study was approved by the ethics
      committee. Each patient or parent (if patient was younger than 18 years), signed 
      an informed consent form before being selected and treated. From December 1997 to
      November 2004, 80 patients with a primary bone malignancy-60 with stage IIb
      disease and 20 with stage III disease (Enneking staging system)-were treated with
      US-guided high-intensity focused ultrasound ablation. High-intensity focused
      ultrasound ablation combined with chemotherapy was performed in 62 patients with 
      osteosarcoma, one patient with periosteal osteosarcoma, and three patients with
      Ewing sarcoma. The remaining 14 patients had chondrosarcoma, giant cell bone
      cancer, periosteal sarcoma, or an unknown malignancy and were treated with
      high-intensity focused ultrasound ablation only. Magnetic resonance (MR) imaging 
      or computed tomography (CT), and single photon emission computed tomography
      (SPECT) were used to assess tumor response. Cumulative survival rates were
      calculated by using the Kaplan-Meier method. Adverse effects were recorded.
      RESULTS: High-intensity focused ultrasound ablation guided by real-time US was
      performed. Follow-up images demonstrated completely ablated malignant bone tumors
      in 69 patients and greater than 50% tumor ablation in the remaining 11 patients. 
      Overall survival rates at 1, 2, 3, 4, and 5 years were 89.8%, 72.3%, 60.5%,
      50.5%, and 50.5%, respectively. Survival rates at 1, 2, 3, 4, and 5 years were
      93.3%, 82.4%, 75.0%, 63.7%, and 63.7%, respectively, in the patients with stage
      IIb cancer and 79.2%, 42.2%, 21.1%, 15.8%, and 15.8%, respectively, in those with
      stage III disease. Among the patients with stage IIb disease, long-term survival 
      rates were substantially improved in the 30 patients who received the full
      treatment-that is, complete high-intensity focused ultrasound and full cycles of 
      chemotherapy-compared with the survival rates for the 24 patients who did not
      finish the chemotherapy cycles and the six patients who underwent partial
      ablation only. Only five (7%) of the 69 patients who underwent complete ablation 
      had local cancer recurrence during the follow-up period. Forty adverse events
      were recorded, with 14 patients requiring surgical intervention. CONCLUSION:
      US-guided high-intensity focused ultrasound ablation of malignant bone tumors is 
      feasible and effective and eventually may be a component of limb-sparing
      techniques for patients with these cancers.
CI  - Copyright RSNA, 2010
FAU - Chen, Wenzhi
AU  - Chen W
AD  - Clinical Center for Tumor Therapy, Second Affiliated Hospital of Chongqing
      Medical University, 74 Linjiang Rd, Chongqing 400010, China.
FAU - Zhu, Hui
AU  - Zhu H
FAU - Zhang, Lian
AU  - Zhang L
FAU - Li, Kequan
AU  - Li K
FAU - Su, Haibing
AU  - Su H
FAU - Jin, Chengbin
AU  - Jin C
FAU - Zhou, Kun
AU  - Zhou K
FAU - Bai, Jin
AU  - Bai J
FAU - Wu, Feng
AU  - Wu F
FAU - Wang, Zhibiao
AU  - Wang Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antineoplastic Agents/administration & dosage
MH  - Bone Neoplasms/diagnostic imaging/pathology/*therapy
MH  - Chemotherapy, Adjuvant
MH  - Child
MH  - Child, Preschool
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Proportional Hazards Models
MH  - Prospective Studies
MH  - Survival Rate
MH  - Tomography, Emission-Computed, Single-Photon
MH  - Tomography, X-Ray Computed
MH  - Treatment Outcome
MH  - Ultrasonic Therapy/*methods
MH  - *Ultrasonography, Interventional
EDAT- 2010/05/27 06:00
MHDA- 2010/07/16 06:00
CRDT- 2010/05/27 06:00
PHST- 2010/05/27 06:00 [entrez]
PHST- 2010/05/27 06:00 [pubmed]
PHST- 2010/07/16 06:00 [medline]
AID - 255/3/967 [pii]
AID - 10.1148/radiol.10090374 [doi]
PST - ppublish
SO  - Radiology. 2010 Jun;255(3):967-78. doi: 10.1148/radiol.10090374.


PMID- 20501732
OWN - NLM
STAT- MEDLINE
DCOM- 20100715
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 255
IP  - 3
DP  - 2010 Jun
TI  - Multidetector CT of the lung: image quality with garnet-based detectors.
PG  - 944-54
LID - 10.1148/radiol.10091010 [doi]
AB  - PURPOSE: To evaluate the image quality of both standard- and reduced-dose
      computed tomography (CT) by comparing multidetector CT with garnet-based
      detectors with multidetector CT with conventional detectors. MATERIALS AND
      METHODS: The study was approved by the internal ethics review board. Informed
      consent was obtained. Eleven cadaveric lungs inflated and fixed by using the
      Heitzman method were scanned by using both CT with garnet-based detectors and CT 
      with conventional detectors. Tube current was 400 mA for standard-dose and 10 mA 
      for reduced-dose CT, and voltage was 120 kVp. Either normal scan mode with 984
      views (conventional and garnet-based detectors) or high-resolution mode with 2496
      views was used. Image quality at conventional-detector CT and
      garnet-based-detector CT in all modes was graded by two independent observers
      with a five-point scale. The evaluation items included normal lung structures,
      subjective visual noise, and abnormal CT findings. Quantitative image noise
      measurements were calculated by measuring the standard deviations in a circular
      region of interest on each selected image. RESULTS: At standard-dose CT, image
      quality at CT with garnet-based detectors (high-resolution mode) was
      significantly improved (P < .001, Tukey-Kramer). However, there was no
      significant difference between quantitative image noise measurements (P > or =
      .24). At reduced-dose CT, only noise differed significantly, with both subjective
      visual noise and quantitative image noise measurements significantly greater at
      CT with garnet-based detectors (high-resolution mode) (P < or = .01). There was
      no significant difference in image quality except for noise between
      conventional-detector CT and garnet-based-detector CT (P > or = .06). CONCLUSION:
      The image quality of standard-dose garnet-based-detector CT (high-resolution) was
      significantly improved. Although highly reduced-dose garnet-based-detector CT
      (high-resolution mode) provided more image noise, overall image quality was not
      different between conventional-detector CT and garnet-based-detector CT.
CI  - Copyright RSNA, 2010
FAU - Yanagawa, Masahiro
AU  - Yanagawa M
AD  - Department of Radiology, Osaka University Graduate School of Medicine, 2-2
      Yamadaoka, Suita-city, Osaka 565-0871, Japan. m-yanagawa@radiol.med.osaka-u.ac.jp
FAU - Tomiyama, Noriyuki
AU  - Tomiyama N
FAU - Honda, Osamu
AU  - Honda O
FAU - Kikuyama, Ayano
AU  - Kikuyama A
FAU - Sumikawa, Hiromitsu
AU  - Sumikawa H
FAU - Inoue, Atsuo
AU  - Inoue A
FAU - Tobino, Kazunori
AU  - Tobino K
FAU - Koyama, Mitsuhiro
AU  - Koyama M
FAU - Kudo, Masayuki
AU  - Kudo M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Cadaver
MH  - Humans
MH  - Lung Diseases/*diagnostic imaging
MH  - Radiation Dosage
MH  - Radiographic Image Interpretation, Computer-Assisted
MH  - Tomography, X-Ray Computed/*instrumentation
EDAT- 2010/05/27 06:00
MHDA- 2010/07/16 06:00
CRDT- 2010/05/27 06:00
PHST- 2010/05/27 06:00 [entrez]
PHST- 2010/05/27 06:00 [pubmed]
PHST- 2010/07/16 06:00 [medline]
AID - 255/3/944 [pii]
AID - 10.1148/radiol.10091010 [doi]
PST - ppublish
SO  - Radiology. 2010 Jun;255(3):944-54. doi: 10.1148/radiol.10091010.


PMID- 20501728
OWN - NLM
STAT- MEDLINE
DCOM- 20100715
LR  - 20100526
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 255
IP  - 3
DP  - 2010 Jun
TI  - Performance of simultaneous cardiac-respiratory self-gated three-dimensional MR
      imaging of the heart: initial experience.
PG  - 909-16
LID - 10.1148/radiol.10091103 [doi]
AB  - This study was approved by the local institutional ethics committee, and informed
      consent was obtained from all volunteers and patients. The objective of the
      present study was to assess the performance of high-spatial-resolution
      three-dimensional prospective cardiac-respiratory self-gated (CRSG) magnetic
      resonance (MR) imaging for determining left ventricular (LV) volumes and mass, as
      well as right ventricular (RV) volumes, in comparison with standard
      electrocardiography (ECG)-triggered, two-dimensional multisection,
      multiple-breath-hold cine imaging. The self-gated method derives cardiac
      triggering and respiratory gating information prospectively on the basis of
      additional MR imaging signals acquired in every repetition time and, thereby,
      eliminates the need for ECG triggering and multiple-breath-hold procedures. Data 
      were acquired in 15 healthy volunteers (mean age, 27.2 years +/- 7.2 [standard
      deviation]) and 11 patients (mean age, 60.7 years +/- 11.3). The bias between the
      self-gating and the reference imaging techniques was minimal for all LV and RV
      parameters (mean values: LV end-diastolic volume, 2.0 mL; LV end-systolic volume,
      0.6 mL; RV end-diastolic volume, 2.2 mL; and RV end-systolic volume, 0.8 mL).
      Prospective CRSG is a valuable alternative to ECG-triggered, multisection,
      multiple-breath-hold cine imaging of the heart and holds considerable promise for
      simplifying functional imaging of the heart, particularly in patients who are
      unable to hold their breath for a long period and patients who show ECG signal
      disturbances.
CI  - Copyright RSNA, 2010
FAU - Manka, Robert
AU  - Manka R
AD  - Institute for Biomedical Engineering, University and ETH Zurich, Gloriastrasse
      35, CH-8092 Zurich, Switzerland. manka@dhzb.de
FAU - Buehrer, Martin
AU  - Buehrer M
FAU - Boesiger, Peter
AU  - Boesiger P
FAU - Fleck, Eckart
AU  - Fleck E
FAU - Kozerke, Sebastian
AU  - Kozerke S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adult
MH  - Electrocardiography
MH  - Feasibility Studies
MH  - Female
MH  - Heart Ventricles/*physiopathology
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Imaging, Three-Dimensional/*methods
MH  - Magnetic Resonance Imaging/*methods
MH  - Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Reproducibility of Results
MH  - Respiration
MH  - Statistics, Nonparametric
EDAT- 2010/05/27 06:00
MHDA- 2010/07/16 06:00
CRDT- 2010/05/27 06:00
PHST- 2010/05/27 06:00 [entrez]
PHST- 2010/05/27 06:00 [pubmed]
PHST- 2010/07/16 06:00 [medline]
AID - 255/3/909 [pii]
AID - 10.1148/radiol.10091103 [doi]
PST - ppublish
SO  - Radiology. 2010 Jun;255(3):909-16. doi: 10.1148/radiol.10091103.


PMID- 20501713
OWN - NLM
STAT- MEDLINE
DCOM- 20100715
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 255
IP  - 3
DP  - 2010 Jun
TI  - Calcifications in digital mammographic screening: improvement of early detection 
      of invasive breast cancers?
PG  - 738-45
LID - 10.1148/radiol.10091173 [doi]
AB  - PURPOSE: To evaluate the relevance of calcifications for invasive breast cancer
      detection in population-based digital mammographic screening. MATERIALS AND
      METHODS: This study was approved by an independent ethics committee, and no
      additional informed consent was required. Prospectively documented radiologic
      cancer features were correlated with pathologic characteristics in 241 breast
      malignancies diagnosed in 24067 participating women aged 50-69 years (part of the
      digital German Screening Program; initial screening rate, 92%; detection rate
      [DR], 1.0%; recall rate [RR], 7.5%). The rates of invasive cancers detected on
      the basis of calcifications were analyzed against pathologic tumor categories (pT
      categories) and histologic grades. For comparison of the study data with results 
      of analog screening, data from the literature regarding calcification-specific
      RR, DR, and positive predictive value for recall (PPV(1)) were calculated.
      RESULTS: The calcification-specific RR was 1.7% (416 of 24067). The
      calcification-specific DR for invasive cancer was 0.12% (29 of 24067), and the
      PPV(1) was 7.0% (29 of 416). Of all malignancies detected on the basis of
      calcification, 38% (29 of 77) were invasive. pT1 cancers showed an inverse
      association between tumor size and rate of detection on the basis of
      calcification; differences in rates among pT1 subcategories were statistically
      significant (P < .001). The proportion of grade 1 pT1 cancers detected on the
      basis of calcification (eight of 27) did not differ significantly from that of
      cancers detected on the basis of other radiologic features (46 of 108, P = .24). 
      The calcification-specific invasive cancer DR was significantly higher for
      digital than for analog mammography. CONCLUSION: One-third of malignancies
      detected on the basis of calcifications only are invasive cancers. They tend to
      be smaller but not less aggressive than invasive cancers detected on the basis of
      other features. Compared with published results of analog screening, digital
      screening offers the potential to increase the rate of invasive cancers detected 
      on the basis of calcifications in population-based mammographic screening.
CI  - Copyright RSNA, 2010
FAU - Weigel, Stefanie
AU  - Weigel S
AD  - Department of Clinical Radiology and Reference Center for Mammography, University
      Hospital Muenster, Albert-Schweitzer-Strasse 33, 48149 Muenster, Germany.
FAU - Decker, Thomas
AU  - Decker T
FAU - Korsching, Eberhard
AU  - Korsching E
FAU - Hungermann, Daniela
AU  - Hungermann D
FAU - Bocker, Werner
AU  - Bocker W
FAU - Heindel, Walter
AU  - Heindel W
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Aged
MH  - Breast Neoplasms/*diagnostic imaging/pathology
MH  - Calcinosis/*diagnostic imaging/pathology
MH  - Chi-Square Distribution
MH  - Early Detection of Cancer/*methods
MH  - Female
MH  - Humans
MH  - Lymphatic Metastasis/diagnostic imaging/pathology
MH  - Mammography/methods
MH  - Middle Aged
MH  - Neoplasm Invasiveness/*diagnostic imaging
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Statistics, Nonparametric
EDAT- 2010/05/27 06:00
MHDA- 2010/07/16 06:00
CRDT- 2010/05/27 06:00
PHST- 2010/05/27 06:00 [entrez]
PHST- 2010/05/27 06:00 [pubmed]
PHST- 2010/07/16 06:00 [medline]
AID - 255/3/738 [pii]
AID - 10.1148/radiol.10091173 [doi]
PST - ppublish
SO  - Radiology. 2010 Jun;255(3):738-45. doi: 10.1148/radiol.10091173.


PMID- 20501544
OWN - NLM
STAT- MEDLINE
DCOM- 20100823
LR  - 20100526
IS  - 1468-2044 (Electronic)
IS  - 0003-9888 (Linking)
VI  - 95
IP  - 6
DP  - 2010 Jun
TI  - Facilitating pharmacokinetic studies in children: a new use of dried blood spots.
PG  - 484-7
LID - 10.1136/adc.2009.177592 [doi]
AB  - Pharmacokinetic data are used to develop dosing regimens for medicines. The dose 
      regimens of many drugs administered to children have historically been based on
      pharmacokinetic data generated in adults. The 'adult' dose was simply adjusted to
      the child's body weight or surface area. This practice is potentially unsafe and 
      not acceptable to drug regulatory agencies. Obtaining pharmacokinetic data in
      children is beset with ethical issues and technical challenges as pharmacokinetic
      studies require repeated measurement of drug levels in blood. Dried blood spot
      (DBS) samples used in conjunction with population pharmacokinetic modelling
      techniques is one potential method for performing pharmacokinetic studies in
      children. In this article, we review the DBS technique for performing
      pharmacokinetic studies and highlight issues that still need to be addressed to
      establish DBS as a method for performing pharmacokinetic studies in children.
FAU - Patel, Parul
AU  - Patel P
AD  - School of Pharmacy, De Montfort University, Leicester, UK.
FAU - Mulla, Hussain
AU  - Mulla H
FAU - Tanna, Sangeeta
AU  - Tanna S
FAU - Pandya, Hitesh
AU  - Pandya H
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Arch Dis Child
JT  - Archives of disease in childhood
JID - 0372434
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Blood Specimen Collection/*methods
MH  - Drug Monitoring/*methods
MH  - Humans
MH  - Pharmaceutical Preparations/blood
MH  - *Pharmacokinetics
MH  - Research Support as Topic
RF  - 32
EDAT- 2010/05/27 06:00
MHDA- 2010/08/24 06:00
CRDT- 2010/05/27 06:00
PHST- 2010/05/27 06:00 [entrez]
PHST- 2010/05/27 06:00 [pubmed]
PHST- 2010/08/24 06:00 [medline]
AID - 95/6/484 [pii]
AID - 10.1136/adc.2009.177592 [doi]
PST - ppublish
SO  - Arch Dis Child. 2010 Jun;95(6):484-7. doi: 10.1136/adc.2009.177592.


PMID- 20501540
OWN - NLM
STAT- MEDLINE
DCOM- 20100823
LR  - 20181201
IS  - 1468-2044 (Electronic)
IS  - 0003-9888 (Linking)
VI  - 95
IP  - 6
DP  - 2010 Jun
TI  - A systematic review of paediatric randomised controlled drug trials published in 
      2007.
PG  - 469-73
LID - 10.1136/adc.2009.173591 [doi]
AB  - OBJECTIVE: To elucidate the current situation of randomised drug trials involving
      the paediatric population. METHODS: Systematic review of paediatric randomised
      controlled trials of medicinal products published in 2007. Three major databases 
      were searched with validated search strategies; Medline, Embase and Cochrane
      Central Register of Controlled Clinical Trials. Data was collected on the
      location, participants, class of drug and methodological quality of the trials.
      RESULTS: Six hundred and four trials were found involving more than 100,000
      paediatric participants. Only about a quarter (146, 24%) were conducted in low
      and lower-middle income countries. Few studies (42, 7%) were performed in
      neonates. Many trials recruiting both adult and paediatric patients inadequately 
      describe the characteristics of the paediatric participants. The most studied
      areas were nervous system (155, 26%), anti-infective (101, 17%) respiratory (74, 
      12%) or antiparasitic (45, 8%) drugs. A high proportion of the studies (36%) used
      an inactive placebo as the comparator. Paediatric randomised drug trials
      performed in low and low-middle income countries were of lower methodological
      quality (mean Jadad score 2.90 vs 3.27, p<0.01), studied more antiparasitic and
      anti-infectives (47% vs 16%, p<0.01) but fewer reported that ethical approval was
      obtained (83% vs 93%, p<0.01), compared to those conducted in high or
      upper-middle income countries. CONCLUSIONS: There are a significant number of
      randomised controlled drug trials involving children taking place throughout the 
      world. To develop the evidence base for safe and effective medicines for the
      benefit of the whole paediatric population, high quality and ethical clinical
      trials should involve a wide range of children.
FAU - Aripin, Khairun N B Nor
AU  - Aripin KN
AD  - Academic Division of Child Health, School of Graduate Entry Medicine and Health
      Sciences, University of Nottingham, Derby, UK. mgxknbn@nottingham.ac.uk
FAU - Choonara, Imti
AU  - Choonara I
FAU - Sammons, Helen M
AU  - Sammons HM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
PL  - England
TA  - Arch Dis Child
JT  - Archives of disease in childhood
JID - 0372434
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Child
MH  - Child, Preschool
MH  - Developing Countries
MH  - Drug Therapy/*methods
MH  - Drug-Related Side Effects and Adverse Reactions
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Patient Selection
MH  - Randomized Controlled Trials as Topic/*methods/standards/statistics & numerical
      data
RF  - 37
EDAT- 2010/05/27 06:00
MHDA- 2010/08/24 06:00
CRDT- 2010/05/27 06:00
PHST- 2010/05/27 06:00 [entrez]
PHST- 2010/05/27 06:00 [pubmed]
PHST- 2010/08/24 06:00 [medline]
AID - adc.2009.173591 [pii]
AID - 10.1136/adc.2009.173591 [doi]
PST - ppublish
SO  - Arch Dis Child. 2010 Jun;95(6):469-73. doi: 10.1136/adc.2009.173591.


PMID- 20501013
OWN - NLM
STAT- MEDLINE
DCOM- 20100616
LR  - 20211020
IS  - 1478-7083 (Electronic)
IS  - 0035-8843 (Linking)
VI  - 92
IP  - 4
DP  - 2010 May
TI  - Law and medical ethics in organ transplantation surgery.
PG  - 282-5
LID - 10.1308/003588410X12664192076250 [doi]
AB  - This article in the series describes how UK law and medical ethics have evolved
      to accommodate developments in organ transplantation surgery. August committees
      have formulated definitions of the point of death of the person which are
      compatible with the lawful procurement of functioning vital organs from cadavers.
      Some of the complexities of dead donor rules are examined. Live donors are a
      major source of kidneys and the laws that protect them are considered. Financial 
      inducements and other incentives to donate erode the noble concept of altruism,
      but should they be unlawful?
FAU - Woodcock, Tom
AU  - Woodcock T
AD  - Department of Anaesthetics, Southampton General Hospital, Southampton, UK.
FAU - Wheeler, Robert
AU  - Wheeler R
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Ann R Coll Surg Engl
JT  - Annals of the Royal College of Surgeons of England
JID - 7506860
SB  - IM
MH  - Animals
MH  - Humans
MH  - Living Donors/ethics/legislation & jurisprudence
MH  - Marketing
MH  - Organ Transplantation/*ethics/*legislation & jurisprudence
MH  - Tissue Donors/ethics/legislation & jurisprudence
MH  - Transplantation, Heterologous
MH  - United Kingdom
RF  - 40
PMC - PMC3025214
EDAT- 2010/05/27 06:00
MHDA- 2010/06/17 06:00
CRDT- 2010/05/27 06:00
PHST- 2010/05/27 06:00 [entrez]
PHST- 2010/05/27 06:00 [pubmed]
PHST- 2010/06/17 06:00 [medline]
AID - 10.1308/003588410X12664192076250 [doi]
PST - ppublish
SO  - Ann R Coll Surg Engl. 2010 May;92(4):282-5. doi:
      10.1308/003588410X12664192076250.


PMID- 20500957
OWN - NLM
STAT- MEDLINE
DCOM- 20100722
LR  - 20180516
IS  - 1701-2163 (Print)
IS  - 1701-2163 (Linking)
VI  - 32
IP  - 5
DP  - 2010 May
TI  - Wanted: inclusive guidelines for research involving pregnant women.
PG  - 473-6
AB  - The Tri-Council Policy Statement: Ethical Conduct for Research Involving Humans
      (TCPS) was first issued in 1998. At that time, the inappropriate exclusion of
      women from clinical trials was a serious problem. Currently, the TCPS is
      undergoing a comprehensive review and it is expected that new research guidelines
      will be issued in 2010. One of the problems with the current draft of the revised
      TCPS is that it fails to properly address the routine exclusion of pregnant women
      from research. We illustrate the negative ethical implications of excluding
      pregnant women from research and argue for changes to the research guidelines
      that would address these negative implications.
FAU - Baylis, Francoise
AU  - Baylis F
AD  - Dalhousie University, Halifax NS, Canada.
FAU - Kaposky, Chris
AU  - Kaposky C
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Obstet Gynaecol Can
JT  - Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et
      gynecologie du Canada : JOGC
JID - 101126664
SB  - IM
MH  - Ethics, Research
MH  - Female
MH  - Humans
MH  - Patient Selection
MH  - *Practice Guidelines as Topic
MH  - Pregnancy
MH  - *Pregnant Women
MH  - *Research Subjects
EDAT- 2010/05/27 06:00
MHDA- 2010/07/23 06:00
CRDT- 2010/05/27 06:00
PHST- 2010/05/27 06:00 [entrez]
PHST- 2010/05/27 06:00 [pubmed]
PHST- 2010/07/23 06:00 [medline]
AID - S1701-2163(16)34502-9 [pii]
PST - ppublish
SO  - J Obstet Gynaecol Can. 2010 May;32(5):473-6.


PMID- 20500926
OWN - NLM
STAT- MEDLINE
DCOM- 20100929
LR  - 20220316
IS  - 1475-2700 (Electronic)
IS  - 0954-4224 (Linking)
VI  - 23
IP  - 1
DP  - 2010 Jun
TI  - Nutritional programming of gastrointestinal tract development. Is the pig a good 
      model for man?
PG  - 4-22
LID - 10.1017/S0954422410000077 [doi]
AB  - The consequences of early-life nutritional programming in man and other mammalian
      species have been studied chiefly at the metabolic level. Very few studies, if
      any, have been performed in the gastrointestinal tract (GIT) as the target organ,
      but extensive GIT studies are needed since the GIT plays a key role in nutrient
      supply and has an impact on functions of the entire organism. The possible
      deleterious effects of nutritional programming at the metabolic level were
      discovered following epidemiological studies in human subjects, and confirmed in 
      animal models. Investigating the impact of programming on GIT structure and
      function would need appropriate animal models due to ethical restrictions in the 
      use of human subjects. The aim of the present review is to discuss the use of
      pigs as an animal model as a compromise between ethically acceptable animal
      studies and the requirement of data which can be interpolated to the human
      situation. In nutritional programming studies, rodents are the most frequently
      used model for man, but GIT development and digestive function in rodents are
      considerably different from those in man. In that aspect, the pig GIT is much
      closer to the human than that of rodents. The swine species is closely comparable
      with man in many nutritional and digestive aspects, and thus provides ample
      opportunity to be used in investigations on the consequences of nutritional
      programming for the GIT. In particular, the 'sow-piglets' dyad could be a useful 
      tool to simulate the 'human mother-infant' dyad in studies which examine short-, 
      middle- and long-term effects and is suggested as the reference model.
FAU - Guilloteau, Paul
AU  - Guilloteau P
AD  - INRA, U1079, Unite Mixte de Recherche-Systeme Elevage, Nutrition Animale et
      Humaine (UMR SENAH), Saint-Gilles, France. Paul.Guilloteau@rennes.inra.fr
FAU - Zabielski, Romuald
AU  - Zabielski R
FAU - Hammon, Harald M
AU  - Hammon HM
FAU - Metges, Cornelia C
AU  - Metges CC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100526
PL  - England
TA  - Nutr Res Rev
JT  - Nutrition research reviews
JID - 9113797
RN  - 0 (Enzymes)
SB  - IM
MH  - Animal Nutritional Physiological Phenomena
MH  - Animals
MH  - Colostrum/chemistry
MH  - Digestion
MH  - Enzymes/metabolism
MH  - Female
MH  - Fetal Development
MH  - Gastrointestinal Motility
MH  - Gastrointestinal Tract/embryology/*growth & development/physiology
MH  - Humans
MH  - Immunity/physiology
MH  - Intestinal Absorption
MH  - Maternal-Fetal Exchange
MH  - Milk/chemistry
MH  - Milk, Human/chemistry
MH  - *Models, Animal
MH  - *Nutritional Physiological Phenomena
MH  - Pregnancy
MH  - *Swine/embryology/physiology
RF  - 230
EDAT- 2010/05/27 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/05/27 06:00
PHST- 2010/05/27 06:00 [entrez]
PHST- 2010/05/27 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - S0954422410000077 [pii]
AID - 10.1017/S0954422410000077 [doi]
PST - ppublish
SO  - Nutr Res Rev. 2010 Jun;23(1):4-22. doi: 10.1017/S0954422410000077. Epub 2010 May 
      26.


PMID- 20500761
OWN - NLM
STAT- MEDLINE
DCOM- 20100923
LR  - 20100526
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 24
IP  - 5
DP  - 2010 Jun
TI  - Inter-ethics: towards an interactive and interdependent bioethics.
PG  - 242-55
LID - 10.1111/j.1467-8519.2010.01810.x [doi]
AB  - Since its origin bioethics has been a specialized, academic discipline, focussing
      on moral issues, using a vast set of globalized principles and rational
      techniques to evaluate and guide healthcare practices. With the emergence of a
      plural society, the loss of faith in experts and authorities and the decline of
      overarching grand narratives and shared moralities, a new approach to bioethics
      is needed. This approach implies a shift from an external critique of practices
      towards embedded ethics and interactive practice improvement, and from a legal
      defence of rights towards fostering interdependent practices of responsibility.
      This article describes these transitions within bioethics in relation to the
      broader societal and cultural dynamics within Western societies, and traces the
      implications for the methodologies and changing roles of the bioethicist. The
      bioethicist we foresee is not just a clever expert but also a relationally
      sensitive person who engages stakeholders in reciprocal dialogues about their
      practice of responsibility and helps to integrate various sorts of knowledge
      (embodied, experiential, visual, and cognitive-scientific). In order to
      illustrate this new approach, we present a case study. It concerns a project
      focusing on an innovation in elderly care, based on the participation of various 
      stakeholders, especially older people themselves.
FAU - Abma, Tineke A
AU  - Abma TA
AD  - Department of Medical Humanities and the EMGO+ Institute for Health and Care
      Research, VU University Medical Centre, Amsterdam, The Netherlands.
      t.abma@vumc.nl
FAU - Baur, Vivianne E
AU  - Baur VE
FAU - Molewijk, Bert
AU  - Molewijk B
FAU - Widdershoven, Guy A M
AU  - Widdershoven GA
LA  - eng
PT  - Journal Article
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Bioethical Issues
MH  - Bioethics/*trends
MH  - Cultural Diversity
MH  - *Diffusion of Innovation
MH  - Dissent and Disputes
MH  - *Ethical Relativism
MH  - *Ethical Theory
MH  - Ethicists
MH  - Forecasting
MH  - Humans
MH  - Interdisciplinary Communication
MH  - Internationality
MH  - Moral Obligations
MH  - Patient Participation
MH  - Philosophy
MH  - Principle-Based Ethics
MH  - Professional Role
MH  - *Social Change
MH  - Western World
EDAT- 2010/05/27 06:00
MHDA- 2010/09/24 06:00
CRDT- 2010/05/27 06:00
PHST- 2010/05/27 06:00 [entrez]
PHST- 2010/05/27 06:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
AID - BIOT1810 [pii]
AID - 10.1111/j.1467-8519.2010.01810.x [doi]
PST - ppublish
SO  - Bioethics. 2010 Jun;24(5):242-55. doi: 10.1111/j.1467-8519.2010.01810.x.


PMID- 20500759
OWN - NLM
STAT- MEDLINE
DCOM- 20100923
LR  - 20100526
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 24
IP  - 5
DP  - 2010 Jun
TI  - The future of bioethics: three dogmas and a cup of hemlock.
PG  - 218-25
LID - 10.1111/j.1467-8519.2010.01814.x [doi]
AB  - In this paper I argue that bioethics is in crisis and that it will not have a
      future unless it begins to embrace a more Socratic approach to its leading
      assumptions. The absence of a critical and sceptical spirit has resulted in
      little more than a dominant ideology. I focus on three key issues. First, that
      too often bioethics collapses into medical ethics. Second, that medical ethics
      itself is beset by a lack of self-reflection that I characterize here as a
      commitment to three dogmas. Third, I offer a more positive perspective by
      suggesting how bioethics may benefit from looking towards public health ethics as
      a new source of inspiration and direction.
FAU - Dawson, Angus
AU  - Dawson A
AD  - Centre for Professional Ethics, Staffordshire, Keele University, UK.
      a.j.dawson@keele.ac.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Bioethics/*trends
MH  - Dissent and Disputes
MH  - *Ethics, Medical
MH  - Forecasting
MH  - Humans
MH  - Moral Obligations
MH  - *Personal Autonomy
MH  - *Philosophy
MH  - Professional Autonomy
MH  - Professional-Patient Relations/ethics
MH  - *Public Health/ethics/trends
EDAT- 2010/05/27 06:00
MHDA- 2010/09/24 06:00
CRDT- 2010/05/27 06:00
PHST- 2010/05/27 06:00 [entrez]
PHST- 2010/05/27 06:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
AID - BIOT1814 [pii]
AID - 10.1111/j.1467-8519.2010.01814.x [doi]
PST - ppublish
SO  - Bioethics. 2010 Jun;24(5):218-25. doi: 10.1111/j.1467-8519.2010.01814.x.


PMID- 20500758
OWN - NLM
STAT- MEDLINE
DCOM- 20100923
LR  - 20141120
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 24
IP  - 5
DP  - 2010 Jun
TI  - The death of bioethics (as we once knew it).
PG  - 211-7
LID - 10.1111/j.1467-8519.2010.01808.x [doi]
AB  - Fast forward 50 years into the future. A look back at what occurred in the field 
      of bioethics since 2010 reveals that a conference in 2050 commemorated the death 
      of bioethics. In a steady progression over the years, the field became
      increasingly fragmented and bureaucratized. Disagreement and dissension were
      rife, and this once flourishing, multidisciplinary field began to splinter in
      multiple ways. Prominent journals folded, one by one, and were replaced with
      specialized publications dealing with genethics, reproethics, nanoethics, and
      necroethics. Mainstream bioethics organizations also collapsed, giving way to new
      associations along disciplinary and sub-disciplinary lines. Physicians
      established their own journals, and specialty groups broke away from more general
      associations of medical ethics. Lawyers also split into three separate factions, 
      and philosophers rejected all but the most rigorous, analytic articles into their
      newly established journal. Matters finally came to a head with global warming,
      the world-wide spread of malaria and dengue, and the cost of medical treatments
      out of reach for almost everyone. The result was the need to develop plans for
      strict rationing of medical care. At the same time, recognition emerged of the
      importance of the right to health and the need for global justice in health. By
      2060, a spark of hope was ignited, opening the door to the resuscitation of
      bioethics and involvement of the global community.
FAU - Macklin, Ruth
AU  - Macklin R
AD  - Department of Epidemiology & PopulationHealth, Albert Einstein College of
      Medicine, Bronx, New York 10461, USA. ruth.macklin@einstein.yu.edu
LA  - eng
PT  - Journal Article
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Bioethics/*trends
MH  - *Dissent and Disputes
MH  - Ethical Theory
MH  - Forecasting
MH  - Global Health
MH  - Humans
MH  - Interdisciplinary Communication
MH  - Periodicals as Topic
MH  - Philosophy
MH  - Politics
MH  - *Professional Autonomy
MH  - Religion
MH  - Societies, Scientific/organization & administration
EDAT- 2010/05/27 06:00
MHDA- 2010/09/24 06:00
CRDT- 2010/05/27 06:00
PHST- 2010/05/27 06:00 [entrez]
PHST- 2010/05/27 06:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
AID - BIOT1808 [pii]
AID - 10.1111/j.1467-8519.2010.01808.x [doi]
PST - ppublish
SO  - Bioethics. 2010 Jun;24(5):211-7. doi: 10.1111/j.1467-8519.2010.01808.x.


PMID- 20500278
OWN - NLM
STAT- MEDLINE
DCOM- 20100902
LR  - 20100526
IS  - 1365-2702 (Electronic)
IS  - 0962-1067 (Linking)
VI  - 19
IP  - 3-4
DP  - 2010 Feb
TI  - The essentials of Advance Care Planning for end-of-life care for older people.
PG  - 389-97
LID - 10.1111/j.1365-2702.2009.03001.x [doi]
AB  - AIMS AND OBJECTIVES: The aim of the study was to investigate the phenomenon of
      Advance Care Planning and the use of Advance Care Directives in residential aged 
      care facilities in Australia. The objectives were to: investigate the
      implementation process of Advance Care Planning and the use of Advance Care
      Directives; investigate the outcomes of Advance Care Planning and experiences of 
      people involved in Advance Care Planning and Advance Care Directives, including
      residents, families and nursing staff. BACKGROUND: Benefits of Advance Care
      Planning for older residents are considerable given their degenerative
      health-breakdown and minimal chance of recovery. To date, the use of Advance Care
      Planning and Advance Care Directives is limited and models of service delivery
      and processes are needed to enhance best practice with Advance Care Planning and 
      positive outcomes for older Australians. DESIGN: Case study. METHODS: The study
      conducted using multiple sources of evidence to enrich understanding of the
      phenomenon of Advance Care Planning. The researcher engaged in data collection
      over six months involving participant observation, field notes, semi-structured
      interviews and document analysis. The findings contribute to the limited
      knowledge of options currently available to older adults and their families in
      their decision-making about end-of-life care options. PERMISSION TO CONDUCT THE
      STUDY: Prior to commencement of the data collection, ethics clearances from the
      University of Newcastle and the regional Area Health Service were achieved.
      Permission to access the residential aged care facilities to undertake the study 
      was obtained from the relevant residential aged care facility ethics committees
      or designated authorities. The researcher undertook several strategies to ensure 
      all the ethical principles were considered and adhered to while conducting the
      project. RESULTS: The research identified the components and factors involved in 
      the Advance Care Planning process and in attaining desired outcomes. The
      conceptual framework developed elaborates how Advance Care Planning should be
      implemented and what may constitute successful implementation of Advance Care
      Planning in residential aged care facilities. The four main elements (input,
      throughput, output, feedback), and 20 sub-elements were requisites for nurses to 
      initiate and implement the Advance Care Planning. CONCLUSION: The essential
      components for end-of-life care are identified in the implementation processes of
      Advance Care Planning in residential aged care facilities. The study contributes 
      to greater awareness of the processes needed for 'dying well' and highlights the 
      need to explore experiences of 'successful dying' and the way nurses contribute
      to these events. RELEVANCE TO CLINICAL PRACTICE: The case study identified four
      determinative requisites for successful implementation of Advance Care Planning
      in aged care facilities: the expert nurse, discussion, education and involvement 
      of a multidisciplinary team. Nurses should take these factors into account and
      use person-centred approach in formalised processes to encourage participation in
      plans for end-of-life care.
FAU - Jeong, Sarah Yeun-Sim
AU  - Jeong SY
AD  - School of Nursing & Midwifery, University of Newcastle, Ourimbah, NSW, Australia.
      Sarah.Jeong@newcastle.edu.au
FAU - Higgins, Isabel
AU  - Higgins I
FAU - McMillan, Margaret
AU  - McMillan M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Clin Nurs
JT  - Journal of clinical nursing
JID - 9207302
MH  - *Advance Directives
MH  - Aged
MH  - Australia
MH  - Humans
MH  - *Planning Techniques
MH  - *Terminal Care
EDAT- 2010/05/27 06:00
MHDA- 2010/09/03 06:00
CRDT- 2010/05/27 06:00
PHST- 2010/05/27 06:00 [entrez]
PHST- 2010/05/27 06:00 [pubmed]
PHST- 2010/09/03 06:00 [medline]
AID - JCN3001 [pii]
AID - 10.1111/j.1365-2702.2009.03001.x [doi]
PST - ppublish
SO  - J Clin Nurs. 2010 Feb;19(3-4):389-97. doi: 10.1111/j.1365-2702.2009.03001.x.


PMID- 20500269
OWN - NLM
STAT- MEDLINE
DCOM- 20100902
LR  - 20181201
IS  - 1365-2702 (Electronic)
IS  - 0962-1067 (Linking)
VI  - 19
IP  - 3-4
DP  - 2010 Feb
TI  - A systematic literature review of incontinence care for persons with dementia:
      the research evidence.
PG  - 303-12
LID - 10.1111/j.1365-2702.2009.02958.x [doi]
AB  - BACKGROUND: Urinary/faecal incontinence in persons with dementia is a potentially
      treatable condition. However, which type of incontinence care is most appropriate
      for persons with dementia remains undecided. AIM: The aim of this study was to
      perform a systematic review of literature on incontinence care in persons with
      dementia focusing on assessment/management and prevention. DESIGN: A systematic
      search of the literature. METHOD: The search was performed in the CINAHL, PubMed 
      and Cochrane Library databases. RESULTS: Of the 48 papers analysed, two were
      systematic literature reviews of management of urinary incontinence including
      persons with dementia. These reviews showed that the best-documented effect of
      toilet assistance for urinary incontinence in elderly persons with/without
      dementia had prompted voiding. However, prompted voiding in persons with dementia
      raises ethical concerns related to the person's integrity and autonomy. Timed
      voiding in combination with additional interventions like incontinence aids,
      staff training on the technique of transferring participants from bed to commode 
      and pharmacological treatment decreased the number of urinary incontinence
      episodes in older persons with/without dementia. There is good scientific
      evidence that prevention of urinary incontinence in elders with/without dementia 
      decreases incontinence or maintains continence. However, the evidence is
      insufficient to describe the state of knowledge of faecal incontinence.
      CONCLUSIONS: Toilet assistance, including timed voiding in combination with
      additional interventions and prompted voiding, are the available evidence-based
      interventions; however, nursing incontinence care is an experience-based
      endeavour for persons with dementia. RELEVANCE TO CLINICAL PRACTICE: There is a
      lack of evidence-based nursing interventions related to incontinence care for
      persons with dementia. More research is needed to show whether experience-based
      incontinence care is effective and which activities are most appropriate for
      persons with dementia. However, the practice of effective nursing will only be
      realised by using several sources of evidence, namely research, clinical
      experience and patient experience.
FAU - Hagglund, Doris
AU  - Hagglund D
AD  - School of Health and Medical Sciences, Family Medicine Research Centre, Orebro
      University, Orebro, Sweden. doris.hagglund@oru.se
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
PL  - England
TA  - J Clin Nurs
JT  - Journal of clinical nursing
JID - 9207302
MH  - Aged
MH  - Aged, 80 and over
MH  - Dementia/complications/*nursing
MH  - Fecal Incontinence/complications/*nursing
MH  - Humans
MH  - Nursing Research
MH  - Prevalence
MH  - Risk Factors
MH  - Urinary Incontinence/complications/*nursing
RF  - 54
EDAT- 2010/05/27 06:00
MHDA- 2010/09/03 06:00
CRDT- 2010/05/27 06:00
PHST- 2010/05/27 06:00 [entrez]
PHST- 2010/05/27 06:00 [pubmed]
PHST- 2010/09/03 06:00 [medline]
AID - JCN2958 [pii]
AID - 10.1111/j.1365-2702.2009.02958.x [doi]
PST - ppublish
SO  - J Clin Nurs. 2010 Feb;19(3-4):303-12. doi: 10.1111/j.1365-2702.2009.02958.x.


PMID- 20500262
OWN - NLM
STAT- MEDLINE
DCOM- 20100824
LR  - 20220409
IS  - 1365-2702 (Electronic)
IS  - 0962-1067 (Linking)
VI  - 19
IP  - 1-2
DP  - 2010 Jan
TI  - A theory of meaning of caregiving for parents of mentally ill children in Taiwan,
      a qualitative study.
PG  - 259-65
LID - 10.1111/j.1365-2702.2009.02984.x [doi]
AB  - AIMS AND OBJECTIVES: The aim of this study is to generate a theory of meaning of 
      care-giving for parents of mentally ill children in Taiwan. BACKGROUND: Studies
      indicate that the meaning of care-giving plays an important role in the
      psychological adjustment of care-givers to care-giving. With a positive meaning
      of care-giving, care-givers can accept their roles and adapt to them more
      readily. DESIGN: The research employs the qualitative method of grounded theory, 
      the inquiry is based on symbolic interactionism. METHODS: Twenty parental
      care-givers of children with schizophrenia were recruited at a private hospital
      in central Taiwan. Semi-structured interviews were conducted. A comparative
      method was used to analyse the text and field notes. RESULTS: Responsibility
      (zeren) emerges as the core category or concept. Responsibility expresses broadly
      the behavioural principles that are culturally prescribed and centred on familial
      ethics and values. Related concepts and principles that influence caregiver
      actions and affections include a return of karma, challenges from local gods and 
      fate. By maintaining their culturally prescribed interpretations of care-giving, 
      parents hope to give care indefinitely without complaints. CONCLUSIONS: The
      findings clearly suggest that the meaning of care-giving is determined through a 
      process of internal debate that is shaped by culturally specific concepts. The
      paper attempts to explain some of these culturally specific determinants and
      explanations of care-giving behaviour. RELEVANCE TO CLINICAL PRACTICE: The theory
      contributes knowledge about the meaning of care-giving for parents of mentally
      ill children in Taiwan. It should be useful reference for mental health
      professionals, who provide counselling services to ethnically Taiwanese
      care-givers.
FAU - Yen, Wen-Jiuan
AU  - Yen WJ
AD  - College of Nursing, Chung Shan Medical University, Taichung, Taiwan.
FAU - Teng, Ching-Hwa
AU  - Teng CH
FAU - Huang, Xuan-Yi
AU  - Huang XY
FAU - Ma, Wei-Fen
AU  - Ma WF
FAU - Lee, Sheuan
AU  - Lee S
FAU - Tseng, Hsiu-Chih
AU  - Tseng HC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Clin Nurs
JT  - Journal of clinical nursing
JID - 9207302
MH  - Aged
MH  - Caregivers/*psychology
MH  - Child
MH  - Child, Preschool
MH  - Disabled Children/*psychology
MH  - Female
MH  - Humans
MH  - Infant
MH  - Interviews as Topic
MH  - Male
MH  - Middle Aged
MH  - Models, Theoretical
MH  - *Persons with Mental Disabilities
MH  - Schizophrenia
MH  - Taiwan
EDAT- 2010/05/27 06:00
MHDA- 2010/08/25 06:00
CRDT- 2010/05/27 06:00
PHST- 2010/05/27 06:00 [entrez]
PHST- 2010/05/27 06:00 [pubmed]
PHST- 2010/08/25 06:00 [medline]
AID - JCN2984 [pii]
AID - 10.1111/j.1365-2702.2009.02984.x [doi]
PST - ppublish
SO  - J Clin Nurs. 2010 Jan;19(1-2):259-65. doi: 10.1111/j.1365-2702.2009.02984.x.


PMID- 20500260
OWN - NLM
STAT- MEDLINE
DCOM- 20100824
LR  - 20220410
IS  - 1365-2702 (Electronic)
IS  - 0962-1067 (Linking)
VI  - 19
IP  - 1-2
DP  - 2010 Jan
TI  - Clinical trials: the challenge of recruitment and retention of participants.
PG  - 227-33
LID - 10.1111/j.1365-2702.2009.03041.x [doi]
AB  - AIMS AND OBJECTIVES: This article, based on the available literature, attempts to
      discuss the importance of recruitment and retention of research participants, the
      associated barriers and challenges, and various strategies to overcome these
      barriers. BACKGROUND: The inability to recruit and retain the required
      participants in a research project poses serious threats to both the internal and
      the external validity of a research study. Despite serious implications, the
      issues of recruitment and retention do not receive due attention in research and 
      publications. Literature suggests a lack of coordinated efforts to collect
      information on the outcomes of recruitment experiences in clinical trials and
      population studies. Studies often mention the number of participants who refuse
      to participate; however, the majority of the studies often fail to mention the
      specific reasons insufficient recruitment or retention of the participants.
      DESIGN: A methodological paper. METHOD: Various participant-, context-,
      environment- and research-related factors are examined that affect the phenomenon
      of recruitment and retention of the participants in a study. RESULTS: Delayed or 
      inefficient recruitment also has financial and ethical implications. Although
      there are many pieces of information scattered throughout academic journals on
      recruitment and retention of participants in research, few authors have dealt
      with the issue holistically. It is imperative for researchers to understand the
      importance of recruitment and retention of research participants, the associated 
      barriers and challenges, and various strategies to overcome these barriers.
      CONCLUSION: Appropriate recording and reporting of the problems faced while
      recruiting and retaining the participants in research studies can help not only
      in understating the challenge, but will also help in devising the strategies to
      overcome this problem. This article was an attempt to synthesise and review the
      available literature on recruitment and retention issues, which demand extensive 
      theoretical and conceptual thinking as part of the research design. RELEVANCE TO 
      PRACTICE: An understanding of the challenges and issues related to recruitment
      and retention can help researchers to think ahead about the strategies to
      overcome these issues and consequently save the time and energy of the
      participants, researchers and funding agencies.
FAU - Gul, Raisa B
AU  - Gul RB
AD  - School of Nursing, Aga Khan University, Karachi, Pakistan. raisa.gul@aku.edu
FAU - Ali, Parveen A
AU  - Ali PA
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Clin Nurs
JT  - Journal of clinical nursing
JID - 9207302
MH  - *Clinical Trials as Topic
MH  - Female
MH  - Humans
MH  - Male
MH  - Nursing Research
MH  - *Patient Dropouts
MH  - *Patient Selection
EDAT- 2010/05/27 06:00
MHDA- 2010/08/25 06:00
CRDT- 2010/05/27 06:00
PHST- 2010/05/27 06:00 [entrez]
PHST- 2010/05/27 06:00 [pubmed]
PHST- 2010/08/25 06:00 [medline]
AID - JCN3041 [pii]
AID - 10.1111/j.1365-2702.2009.03041.x [doi]
PST - ppublish
SO  - J Clin Nurs. 2010 Jan;19(1-2):227-33. doi: 10.1111/j.1365-2702.2009.03041.x.


PMID- 20500065
OWN - NLM
STAT- MEDLINE
DCOM- 20140730
LR  - 20211020
IS  - 1545-1569 (Electronic)
IS  - 1055-6656 (Linking)
VI  - 48
IP  - 2
DP  - 2011 Mar
TI  - A case of 3q29 microdeletion syndrome involving oral cleft inherited from a
      nonaffected mosaic parent: molecular analysis and ethical implications.
PG  - 222-30
LID - 10.1597/09-149 [doi]
AB  - OBJECTIVE: The objective of this study was to use array comparative genomic
      hybridization to detect causal microdeletions in samples of subjects with cleft
      lip and palate. SUBJECTS: We analyzed DNA samples from a male patient and his
      parents seen during surgical screening for an Operation Smile medical mission in 
      the Philippines. METHOD: We used Affymetrix(R) Genome-Wide Human SNP Array 6.0
      followed by sequencing and quantitative polymerase chain reaction using SYBR
      Green I dye. RESULTS: We report the second case of 3q29 microdeletion syndrome
      including cleft lip with or without cleft palate and the first case of this
      microdeletion syndrome inherited from a phenotypically normal mosaic parent.
      CONCLUSIONS: Our findings confirm the usefulness of a comparative genomic
      hybridization to detect causal microdeletions and indicate that parental somatic 
      mosaicism should be considered in healthy parents for genetic counseling of the
      families. We discuss important ethical implications of sharing health impact
      results from research studies with the participant families.
FAU - Petrin, Aline L
AU  - Petrin AL
FAU - Daack-Hirsch, Sandra
AU  - Daack-Hirsch S
FAU - L'Heureux, Jamie
AU  - L'Heureux J
FAU - Murray, Jeffrey C
AU  - Murray JC
LA  - eng
GR  - R37 DE008559/DE/NIDCR NIH HHS/United States
GR  - DE08559/DE/NIDCR NIH HHS/United States
GR  - P50 DE009170-100002/DE/NIDCR NIH HHS/United States
GR  - R37 DE008559-20/DE/NIDCR NIH HHS/United States
GR  - R01 DE008559/DE/NIDCR NIH HHS/United States
GR  - P50 DE09170/DE/NIDCR NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20100504
PL  - United States
TA  - Cleft Palate Craniofac J
JT  - The Cleft palate-craniofacial journal : official publication of the American
      Cleft Palate-Craniofacial Association
JID - 9102566
RN  - Chromosome 3q29 Deletion Syndrome
RN  - Mosaic variegated aneuploidy syndrome
SB  - IM
MH  - Chromosome Deletion
MH  - Chromosome Disorders
MH  - Chromosomes, Human, Pair 3/genetics
MH  - Cleft Lip/*genetics
MH  - Cleft Palate/*genetics
MH  - Developmental Disabilities/genetics
MH  - Humans
MH  - Infant
MH  - Intellectual Disability/*genetics
MH  - Male
MH  - Mosaicism
MH  - Oligonucleotide Array Sequence Analysis
MH  - Phenotype
MH  - Philippines
MH  - Polymorphism, Single Nucleotide
MH  - Real-Time Polymerase Chain Reaction
PMC - PMC2964377
MID - NIHMS209391
EDAT- 2010/05/27 06:00
MHDA- 2014/07/31 06:00
CRDT- 2010/05/27 06:00
PHST- 2010/05/27 06:00 [entrez]
PHST- 2010/05/27 06:00 [pubmed]
PHST- 2014/07/31 06:00 [medline]
AID - 10.1597/09-149 [doi]
PST - ppublish
SO  - Cleft Palate Craniofac J. 2011 Mar;48(2):222-30. doi: 10.1597/09-149. Epub 2010
      May 4.


PMID- 20499820
OWN - NLM
STAT- MEDLINE
DCOM- 20100708
LR  - 20150826
IS  - 0370-629X (Print)
IS  - 0370-629X (Linking)
VI  - 65
IP  - 4
DP  - 2010 Apr
TI  - [The future of radiation oncology: technology, ethical considerations and
      economical aspects].
PG  - 186-90
AB  - We are facing a real technical revolution in radiation oncology. The radiation
      oncologist is pushed by the industry to implement rapidly new and "high-tech"
      therapeutic modalities. All of the technical improvements are obviously aiming at
      an increase in the therapeutic index. However, one should be cautious before
      implementing on a large scale those technical innovations as no one really knows 
      neither what the possible impact is on medical outcome (efficacy, toxicity and
      risk), nor what the economical consequences will be. It is our duty as radiation 
      oncologists to make a comprehensive estimation of the impacts in order to be able
      to set up guidelines for use that are both ethical and in respectful of human
      dignity.
FAU - Coucke, P
AU  - Coucke P
AD  - Service de Radiotherapie, CHU de Liege, Belgique.
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - La radio-oncologie de demain: comment concilier l'ethique, le developpement
      technique et les aspects economiques?
PL  - Belgium
TA  - Rev Med Liege
JT  - Revue medicale de Liege
JID - 0404317
SB  - IM
MH  - Ethics, Medical
MH  - Humans
MH  - Neoplasms/*radiotherapy
MH  - Practice Guidelines as Topic
MH  - Radiation Oncology/economics/ethics/methods/*trends
EDAT- 2010/05/27 06:00
MHDA- 2010/07/09 06:00
CRDT- 2010/05/27 06:00
PHST- 2010/05/27 06:00 [entrez]
PHST- 2010/05/27 06:00 [pubmed]
PHST- 2010/07/09 06:00 [medline]
PST - ppublish
SO  - Rev Med Liege. 2010 Apr;65(4):186-90.


PMID- 20499174
OWN - NLM
STAT- MEDLINE
DCOM- 20110120
LR  - 20211020
IS  - 1573-2568 (Electronic)
IS  - 0163-2116 (Linking)
VI  - 56
IP  - 1
DP  - 2011 Jan
TI  - Liver transplantation for alcohol-related cirrhosis: a single centre long-term
      clinical and histological follow-up.
PG  - 236-43
LID - 10.1007/s10620-010-1281-7 [doi]
AB  - BACKGROUND: Alcohol-induced liver cirrhosis is one of the leading indications for
      liver transplantation today. Due to the general organ shortage and continuous
      deaths on the waiting list there has been some debate on the issue of indication 
      and ethical problems. It was the aim of this study to critically analyse the
      outcome of patients with alcoholic cirrhosis transplanted at our centre with
      special emphasis on alcohol-recurrence frequency and long-term histological
      follow-up. METHODS: Three hundred five patients who received LT for alcoholic
      cirrhosis at our institution were followed over a period of 3-10 years after
      transplantation. Biopsies were taken 1, 3, 5, and 10 years after LT. Specimens
      were analysed and staged concerning inflammation, rejection, fatty involution,
      and fibrosis/cirrhosis. Clinical characteristics as well as serological
      parameters, immunosuppressive protocols, rejection episodes, and patient and
      graft survival were recorded. RESULTS: Recurrence of alcohol abuse occurred in
      27% of all patients analysed. Regardless of alcohol consumption, 5-year graft and
      patient survival were excellent; after 10 years abstinent patients showed
      significantly better survival (82% vs. 68%; P=0.017). Histological changes were
      slightly more pronounced among recurrent drinkers, no significant difference
      regarding inflammation or fibrosis was detected. CONCLUSION: Patients undergoing 
      LT for alcohol-induced cirrhosis show excellent long-term survival rates with
      stable graft function. Alcohol recurrence impairs long-term prognosis; however,
      compared to other patient sub-populations (HCC, HCV) results are clearly above
      average.
FAU - Schmeding, M
AU  - Schmeding M
AD  - Department of General and Transplantation Surgery, Charite University Hospital,
      Campus Virchow Clinic, Augustenburger Platz 1, 13353, Berlin, Germany.
      maximilian.schmeding@charite.de
FAU - Heidenhain, C
AU  - Heidenhain C
FAU - Neuhaus, R
AU  - Neuhaus R
FAU - Neuhaus, P
AU  - Neuhaus P
FAU - Neumann, U P
AU  - Neumann UP
LA  - eng
PT  - Journal Article
DEP - 20100525
PL  - United States
TA  - Dig Dis Sci
JT  - Digestive diseases and sciences
JID - 7902782
SB  - IM
MH  - Adult
MH  - Biopsy
MH  - Female
MH  - Follow-Up Studies
MH  - Graft Rejection/epidemiology
MH  - Humans
MH  - Incidence
MH  - Liver/pathology
MH  - Liver Cirrhosis, Alcoholic/mortality/*surgery
MH  - *Liver Transplantation
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Survival Rate
MH  - Treatment Outcome
EDAT- 2010/05/26 06:00
MHDA- 2011/01/21 06:00
CRDT- 2010/05/26 06:00
PHST- 2010/02/25 00:00 [received]
PHST- 2010/05/04 00:00 [accepted]
PHST- 2010/05/26 06:00 [entrez]
PHST- 2010/05/26 06:00 [pubmed]
PHST- 2011/01/21 06:00 [medline]
AID - 10.1007/s10620-010-1281-7 [doi]
PST - ppublish
SO  - Dig Dis Sci. 2011 Jan;56(1):236-43. doi: 10.1007/s10620-010-1281-7. Epub 2010 May
      25.


PMID- 20499038
OWN - NLM
STAT- MEDLINE
DCOM- 20151022
LR  - 20100525
IS  - 1972-6007 (Electronic)
IS  - 0009-9074 (Linking)
VI  - 161
IP  - 2
DP  - 2010
TI  - Communication (action with communicative content).
PG  - 193-4
AB  - The term Communication generally designate the transmission of a message of
      concepts, feelings or needs from a speaker to a receiver by means of verbal or no
      verbal language. The pragmatic approach to human communication has put in
      evidence a further implication of this concept: every behaviour therefore has a
      value even when it is not intentional. Recently, a more dynamic concept of
      communication has been elaborated where communication means communicative action.
      This interpretation is the starting point for the theory of the "communicative
      acting" and subsequently of the so called discourse ethic elaborated by J.
      Habermas.
FAU - Russo, M T
AU  - Russo MT
AD  - Institute of Philosophy of Scientific and Technological Activity, University
      Campus Bio-Medico of Rome, Italy. m.russo@unicampus.it
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Clin Ter
JT  - La Clinica terapeutica
JID - 0372604
SB  - IM
MH  - *Communication
MH  - Dictionaries as Topic
MH  - Humans
EDAT- 2010/05/26 06:00
MHDA- 2015/10/23 06:00
CRDT- 2010/05/26 06:00
PHST- 2010/05/26 06:00 [entrez]
PHST- 2010/05/26 06:00 [pubmed]
PHST- 2015/10/23 06:00 [medline]
PST - ppublish
SO  - Clin Ter. 2010;161(2):193-4.


PMID- 20498666
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20220331
IS  - 1759-4782 (Electronic)
IS  - 1759-4774 (Linking)
VI  - 7
IP  - 8
DP  - 2010 Aug
TI  - The Oncofertility Consortium--addressing fertility in young people with cancer.
PG  - 466-75
LID - 10.1038/nrclinonc.2010.81 [doi]
AB  - The number of young cancer survivors is increasing owing to advances in cancer
      therapeutics, but many face infertility as a result of their treatment.
      Technologies that already exist for cancer patients concerned about their future 
      fertility include sperm banking for men and hormonal intervention followed by in 
      vitro fertilization and embryo cryopreservation for women. However, logistical
      barriers to timely patient referral and coordination of care between specialties 
      can limit patient access to all the available options. Moreover, there are few
      alternatives for young women and girls who cannot delay their cancer treatment,
      or who are unable to undergo hormonal intervention. The Oncofertility Consortium 
      is a network of researchers, physicians and scholars who are advancing fertility 
      preservation options for young cancer patients. Research into the societal,
      ethical, and legal implications is also an important part of the work performed
      by the Oncofertility Consortium, which is providing new perspectives on patient
      decision-making about how to access these emerging reproductive technologies.
      Experts in the fields of oncology, reproductive medicine, the social sciences,
      law, education, and the humanities are working together to develop
      next-generation reproductive interventions and promote communication between
      scholars, clinicians, patients, and the public to ensure that young cancer
      patients are equipped with the most appropriate information and options for
      having a family in the future.
FAU - Woodruff, Teresa K
AU  - Woodruff TK
AD  - Northwestern University Feinberg School of Medicine, Department of Obstetrics and
      Gynecology, Division of Fertility Preservation, 303 East Superior Street, Lurie
      10-119, Chicago, IL 60211, USA. tkw@northwestern.edu
LA  - eng
GR  - RL1 HD058294/HD/NICHD NIH HHS/United States
GR  - RL1 HD058293/HD/NICHD NIH HHS/United States
GR  - U54 HD041857/HD/NICHD NIH HHS/United States
GR  - RL9 CA133838/CA/NCI NIH HHS/United States
GR  - PL1 EB008542/EB/NIBIB NIH HHS/United States
GR  - 8UL1DE019587/DE/NIDCR NIH HHS/United States
GR  - 1RL1HD058294/HD/NICHD NIH HHS/United States
GR  - 5RL9CA133838/CA/NCI NIH HHS/United States
GR  - KL1 CA133839/CA/NCI NIH HHS/United States
GR  - 5TL1CA133837/CA/NCI NIH HHS/United States
GR  - 5PL1EB008542/EB/NIBIB NIH HHS/United States
GR  - 1RL1HD058293/HD/NICHD NIH HHS/United States
GR  - 1KL1CA133839/CA/NCI NIH HHS/United States
GR  - RL1 HD058296/HD/NICHD NIH HHS/United States
GR  - UL1 DE019587/DE/NIDCR NIH HHS/United States
GR  - RL5 CA133836/CA/NCI NIH HHS/United States
GR  - U54HD041857/HD/NICHD NIH HHS/United States
GR  - PL1 CA133835/CA/NCI NIH HHS/United States
GR  - 5RL1HD058295/HD/NICHD NIH HHS/United States
GR  - RL1 HD058295/HD/NICHD NIH HHS/United States
GR  - 1PL1CA133835/CA/NCI NIH HHS/United States
GR  - TL1 CA133837/CA/NCI NIH HHS/United States
GR  - 5RL5CA133836/CA/NCI NIH HHS/United States
GR  - UL1 DE019587-03/DE/NIDCR NIH HHS/United States
GR  - 5RL1HD058296/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20100525
PL  - England
TA  - Nat Rev Clin Oncol
JT  - Nature reviews. Clinical oncology
JID - 101500077
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Biological Specimen Banks
MH  - Cryopreservation
MH  - Decision Making
MH  - Female
MH  - *Fertility
MH  - Fertilization in Vitro
MH  - Humans
MH  - Infections/*etiology/mortality
MH  - Infertility, Female/chemically induced/etiology/*prevention & control
MH  - Infertility, Male/chemically induced/etiology/*prevention & control
MH  - Male
MH  - National Institutes of Health (U.S.)
MH  - Neoplasms/*complications/mortality
MH  - Prognosis
MH  - Sperm Banks
MH  - United States
MH  - Young Adult
PMC - PMC3124936
MID - NIHMS301170
EDAT- 2010/05/26 06:00
MHDA- 2011/06/03 06:00
CRDT- 2010/05/26 06:00
PHST- 2010/05/26 06:00 [entrez]
PHST- 2010/05/26 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
AID - nrclinonc.2010.81 [pii]
AID - 10.1038/nrclinonc.2010.81 [doi]
PST - ppublish
SO  - Nat Rev Clin Oncol. 2010 Aug;7(8):466-75. doi: 10.1038/nrclinonc.2010.81. Epub
      2010 May 25.


PMID- 20498600
OWN - NLM
STAT- MEDLINE
DCOM- 20101028
LR  - 20100715
IS  - 1531-698X (Electronic)
IS  - 1040-8703 (Linking)
VI  - 22
IP  - 4
DP  - 2010 Aug
TI  - Ethics and adolescent care: an international perspective.
PG  - 418-22
LID - 10.1097/MOP.0b013e32833b53ec [doi]
AB  - PURPOSE OF REVIEW: This update reviews the concepts underlying ethical issues in 
      various contexts and countries, highlighting the evolution in the use of the core
      values underpinning the field and practice of bioethics as applied to healthcare.
      RECENT FINDINGS: It stresses the specific position of the adolescent as being a
      unique individual searching for autonomy and, most of the time, being competent
      to make decisions regarding the adolescent's own health. It briefly outlines the 
      principles of a 'deliberative' approach in which the practitioner, while keeping 
      in mind the legal context of the country where the practitioner is working,
      assesses to what extent the adolescent can be considered as competent, and then
      discusses with the adolescent the medical and psychosocial aspects of the various
      actions to be taken in a situation, as well as the basic ethical values linked
      with each of the various options available. The deliberation can involve relevant
      stakeholders, provided the issues concerning confidentiality have been fully
      discussed with the adolescent. SUMMARY: This process forces the practitioner, the
      adolescent patient and those who care for the adolescent patient to look outside 
      their usual frameworks and make a decision that is in the best interest of the
      young person, and is informed by various ethical values.
FAU - Michaud, Pierre-Andre
AU  - Michaud PA
AD  - Centre hospitalier universitaire vaudois, Lausanne, Switzerland.
      Pierre-Andre.Michaud@chuv.ch
FAU - Berg-Kelly, Kristina
AU  - Berg-Kelly K
FAU - Macfarlane, Aidan
AU  - Macfarlane A
FAU - Benaroyo, Lazare
AU  - Benaroyo L
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Pediatr
JT  - Current opinion in pediatrics
JID - 9000850
SB  - IM
MH  - Adolescent
MH  - Adolescent Health Services/*ethics
MH  - *Ethics, Medical
MH  - Humans
MH  - *International Cooperation
EDAT- 2010/05/26 06:00
MHDA- 2010/10/29 06:00
CRDT- 2010/05/26 06:00
PHST- 2010/05/26 06:00 [entrez]
PHST- 2010/05/26 06:00 [pubmed]
PHST- 2010/10/29 06:00 [medline]
AID - 10.1097/MOP.0b013e32833b53ec [doi]
PST - ppublish
SO  - Curr Opin Pediatr. 2010 Aug;22(4):418-22. doi: 10.1097/MOP.0b013e32833b53ec.


PMID- 20498534
OWN - NLM
STAT- MEDLINE
DCOM- 20100610
LR  - 20161125
IS  - 1532-3145 (Electronic)
IS  - 0363-8715 (Linking)
VI  - 34
IP  - 3
DP  - 2010 May-Jun
TI  - Acute ischemic cholecystitis after transarterial chemoembolization of
      hepatocellular carcinoma: incidence and clinical outcome.
PG  - 348-53
LID - 10.1097/RCT.0b013e3181caaea3 [doi]
AB  - PURPOSE: To determine the incidence and clinical outcome of acute ischemic
      cholecystitis after transarterial chemoembolization (TACE) of hepatocellular
      carcinoma. MATERIALS AND METHODS: In this ethics board-approved study, a
      retrospective review of 355 TACE procedures performed in 246 patients during a
      5-year period was performed. The review of postintervention computed tomography
      (CT) reports for findings indicative of acute cholecystitis identified 12
      patients (4.9%). In these patients, all CT scans, laboratory results (white blood
      cell count, alkaline phosphatase level, total bilirubin level), and clinical
      reports were analyzed to assess imaging findings and outcomes at the following
      time points: before TACE, within the first week after the procedure, as well as 1
      and 6 months post-TACE. RESULTS: In 11 of 12 cases, the dominant finding on CT
      was new gallbladder wall thickening of up to 12 mm, which developed within 24
      hours in 10 patients and within the first month after TACE in 1 patient.
      Gallbladder wall thickening persisted in 1 patient for at least 6 months. Eleven 
      of 12 patients showed deposition of Lipiodol in the gallbladder wall. In 1
      patient, the dominant finding on CT was pericholecystic stranding that resolved
      on follow-up CT after 1 month. None of the patients demonstrated gas in the
      gallbladder wall, significant pericholecystic fluid, abdominal or liver
      abscesses. Blood work results revealed transient increase in white blood cell
      count, alkaline phosphatase level, and total bilirubin level, not different from 
      that seen after TACE in patients without CT evidence of cholecystitis. Clinical
      reports documented transient right upper quadrant pain for a few days and up to 1
      month in 1 case with eventual symptom relief. None of the cases required surgical
      or radiological intervention. All but 1 case demonstrated normal gallbladder wall
      thickness after 6 months. CONCLUSIONS: Acute ischemic cholecystitis is not an
      uncommon complication after TACE. However, it is self-limiting and does not seem 
      to require any intervention or surgery.
FAU - Wagnetz, Ute
AU  - Wagnetz U
AD  - Joint Department of Medical Imaging, University Health Network, Mount Sinai
      Hospital and Women's College Hospital, University of Toronto, Toronto, Ontario,
      Canada.
FAU - Jaskolka, Jeff
AU  - Jaskolka J
FAU - Yang, Peter
AU  - Yang P
FAU - Jhaveri, Kartik S
AU  - Jhaveri KS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Comput Assist Tomogr
JT  - Journal of computer assisted tomography
JID - 7703942
SB  - IM
MH  - Acute Disease
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Hepatocellular/*therapy
MH  - Chemoembolization, Therapeutic/*adverse effects
MH  - Cholecystitis/*diagnostic imaging/*etiology
MH  - Cholecystography
MH  - Female
MH  - Humans
MH  - Ischemia/*etiology
MH  - Liver Neoplasms/*therapy
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - *Tomography, X-Ray Computed/methods
MH  - Treatment Outcome
EDAT- 2010/05/26 06:00
MHDA- 2010/06/11 06:00
CRDT- 2010/05/26 06:00
PHST- 2010/05/26 06:00 [entrez]
PHST- 2010/05/26 06:00 [pubmed]
PHST- 2010/06/11 06:00 [medline]
AID - 10.1097/RCT.0b013e3181caaea3 [doi]
AID - 00004728-201005000-00005 [pii]
PST - ppublish
SO  - J Comput Assist Tomogr. 2010 May-Jun;34(3):348-53. doi:
      10.1097/RCT.0b013e3181caaea3.


PMID- 20498185
OWN - NLM
STAT- MEDLINE
DCOM- 20100818
LR  - 20100525
IS  - 1474-7766 (Electronic)
IS  - 1474-7758 (Linking)
VI  - 10
IP  - 3
DP  - 2010 Jun
TI  - Advance planning in end-of-life care: legal and ethical considerations for
      neurologists.
PG  - 140-4
LID - 10.1136/jnnp.2009.200113 [doi]
AB  - Neurological illnesses can leave patients unable to make legally valid decisions 
      about their medical treatment. However, this loss of decision making capacity can
      often be predicted in advance. The law in the UK now enables patients to make
      legally binding arrangements to either refuse specific treatments in advance or
      to appoint others to make decisions on their behalf. This article discusses the
      mechanics of advance planning under UK law and the role of the neurologist in
      helping patients to plan ahead.
FAU - Kerrigan, Simon
AU  - Kerrigan S
AD  - Solicitor and Specialist Registrar in Neurology, Edinburgh Centre for
      Neuro-oncology, Western General Hospital, Edinburgh, UK. simon.kerrigan@nhs.net
FAU - Ormerod, Ian
AU  - Ormerod I
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Pract Neurol
JT  - Practical neurology
JID - 101130961
SB  - IM
MH  - Humans
MH  - Informed Consent
MH  - *Nervous System Diseases
MH  - Neurology/*legislation & jurisprudence
MH  - Patient Care Planning/*ethics/*legislation & jurisprudence
MH  - Terminal Care/*ethics/*legislation & jurisprudence
MH  - Third-Party Consent
RF  - 8
EDAT- 2010/05/26 06:00
MHDA- 2010/08/19 06:00
CRDT- 2010/05/26 06:00
PHST- 2010/05/26 06:00 [entrez]
PHST- 2010/05/26 06:00 [pubmed]
PHST- 2010/08/19 06:00 [medline]
AID - 10/3/140 [pii]
AID - 10.1136/jnnp.2009.200113 [doi]
PST - ppublish
SO  - Pract Neurol. 2010 Jun;10(3):140-4. doi: 10.1136/jnnp.2009.200113.


PMID- 20497965
OWN - NLM
STAT- MEDLINE
DCOM- 20110314
LR  - 20220310
IS  - 1569-8041 (Electronic)
IS  - 0923-7534 (Linking)
VI  - 21
IP  - 12
DP  - 2010 Dec
TI  - Should progression-free survival be the primary measure of efficacy for advanced 
      NSCLC therapy?
PG  - 2324-2332
LID - S0923-7534(19)39247-6 [pii]
LID - 10.1093/annonc/mdq204 [doi]
AB  - Non-small-cell lung cancer (NSCLC) is a leading cause of malignancy-related
      mortality in the Western world. Despite advances in early detection and standard 
      treatment, NSCLC is frequently diagnosed at an advanced stage and therefore
      patients have a poor prognosis. However, its heterogeneity provides ample
      opportunity for multiple treatment approaches and target pathways. Considerable
      progress has been made in identifying novel targets, leading to a growing number 
      of treatment options. Overall survival (OS) may not always be the most
      appropriate primary end point for assessment of efficacy, as it is likely that
      patients with NSCLC will receive multiple lines of therapy during their
      treatment. Additionally, crossover appears as an ethical necessity to many
      investigators if molecular targeted agents display outstanding early efficacy.
      While improving OS remains the goal for clinicians, progression-free survival
      (PFS) is increasingly being utilised as an alternative end point. In this
      article, we will evaluate the value of PFS as a primary measure of efficacy for
      advanced NSCLC, compare the clinical situation with that in other solid
      malignancies and review the growing number of treatment options for NSCLC.
FAU - Soria, J C
AU  - Soria JC
AD  - Department of Medicine, Institut Gustave Roussy, Villejuif, France. Electronic
      address: Jean-Charles.Soria@igr.fr.
FAU - Massard, C
AU  - Massard C
AD  - Department of Medicine, Institut Gustave Roussy, Villejuif, France.
FAU - Le Chevalier, T
AU  - Le Chevalier T
AD  - Department of Medicine, Institut Gustave Roussy, Villejuif, France.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100523
PL  - England
TA  - Ann Oncol
JT  - Annals of oncology : official journal of the European Society for Medical
      Oncology
JID - 9007735
SB  - IM
MH  - Carcinoma, Non-Small-Cell Lung/*diagnosis/pathology/*therapy
MH  - Clinical Trials as Topic/methods
MH  - Diagnostic Techniques and Procedures
MH  - Disease Progression
MH  - Disease-Free Survival
MH  - Endpoint Determination/methods
MH  - Humans
MH  - Lung Neoplasms/*diagnosis/pathology/*therapy
MH  - Prognosis
MH  - Treatment Outcome
EDAT- 2010/05/26 06:00
MHDA- 2011/03/15 06:00
CRDT- 2010/05/26 06:00
PHST- 2010/05/26 06:00 [entrez]
PHST- 2010/05/26 06:00 [pubmed]
PHST- 2011/03/15 06:00 [medline]
AID - S0923-7534(19)39247-6 [pii]
AID - 10.1093/annonc/mdq204 [doi]
PST - ppublish
SO  - Ann Oncol. 2010 Dec;21(12):2324-2332. doi: 10.1093/annonc/mdq204. Epub 2010 May
      23.


PMID- 20497171
OWN - NLM
STAT- MEDLINE
DCOM- 20120518
LR  - 20120119
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 26
IP  - 2
DP  - 2012 Feb
TI  - When concretized emotion-belief complexes derail decision-making capacity.
PG  - 108-16
LID - 10.1111/j.1467-8519.2010.01817.x [doi]
AB  - There is an important gap in philosophical, clinical and bioethical conceptions
      of decision-making capacity. These fields recognize that when traumatic life
      circumstances occur, people not only feel afraid and demoralized, but may develop
      catastrophic thinking and other beliefs that can lead to poor judgment. Yet there
      has been no articulation of the ways in which such beliefs may actually derail
      decision-making capacity. In particular, certain emotionally grounded beliefs are
      systematically unresponsive to evidence, and this can block the ability to
      deliberate about alternatives. People who meet medico-legal criteria for
      decision-making capacity can react to health and personal crises with such
      capacity-derailing reactions. One aspect of this is that a person who is
      otherwise cognitively intact may be unable to appreciate her own future quality
      of life while in this complex state of mind. This raises troubling ethical
      challenges. We cannot rely on the current standard assessment of cognition to
      determine decisional rights in medical and other settings. We need to understand 
      better how emotionally grounded beliefs interfere with decision-making capacity, 
      in order to identify when caregivers have an obligation to intervene.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Halpern, Jodi
AU  - Halpern J
AD  - University of California, Berkeley, USA. jhalpern@berkeley.edu
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20100517
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - *Culture
MH  - *Decision Making
MH  - *Emotions
MH  - Female
MH  - Humans
MH  - Mental Competency
MH  - Middle Aged
MH  - *Treatment Refusal/ethics
EDAT- 2010/05/26 06:00
MHDA- 2012/05/19 06:00
CRDT- 2010/05/26 06:00
PHST- 2010/05/26 06:00 [entrez]
PHST- 2010/05/26 06:00 [pubmed]
PHST- 2012/05/19 06:00 [medline]
AID - BIOT1817 [pii]
AID - 10.1111/j.1467-8519.2010.01817.x [doi]
PST - ppublish
SO  - Bioethics. 2012 Feb;26(2):108-16. doi: 10.1111/j.1467-8519.2010.01817.x. Epub
      2010 May 17.


PMID- 20497166
OWN - NLM
STAT- MEDLINE
DCOM- 20120711
LR  - 20120203
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 26
IP  - 3
DP  - 2012 Mar
TI  - Reflections on 'autistic integrity'.
PG  - 164-70
LID - 10.1111/j.1467-8519.2010.01827.x [doi]
AB  - Autism, particularly its moderate to severe forms, has prompted considerable
      scientific study and clinical involvement because the associated behaviours imply
      disconnections with valued features of a 'good' life, such as close
      relationships, enjoyment, and adaptability. Proposed causes of autism involve
      potent philosophical concepts including consciousness, identity, mind, and
      relationality. The concept of autistic integrity is used by Barnbaum in The
      Ethics of Autism: Among Them, But Not of Them to help provide moral justification
      to stop efforts to cure adults with autism, especially if the cause is presumed
      to be a lack of a theory of mind.(1) This article has two goals: (1) to apply
      four familiar definitions or characterizations of integrity to the case of
      moderate to severe autism, and (2) to examine whether autistic integrity does
      provide the moral justification Barnbaum seeks.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Russell, Barbara
AU  - Russell B
AD  - Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
      barbara_russell@camh.net
LA  - eng
PT  - Journal Article
DEP - 20100517
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Adult
MH  - Autistic Disorder/*psychology/*rehabilitation
MH  - Canada
MH  - Child
MH  - *Ethics, Medical
MH  - Human Rights
MH  - Humans
MH  - *Moral Obligations
MH  - Rehabilitation/ethics
EDAT- 2010/05/26 06:00
MHDA- 2012/07/12 06:00
CRDT- 2010/05/26 06:00
PHST- 2010/05/26 06:00 [entrez]
PHST- 2010/05/26 06:00 [pubmed]
PHST- 2012/07/12 06:00 [medline]
AID - BIOT1827 [pii]
AID - 10.1111/j.1467-8519.2010.01827.x [doi]
PST - ppublish
SO  - Bioethics. 2012 Mar;26(3):164-70. doi: 10.1111/j.1467-8519.2010.01827.x. Epub
      2010 May 17.


PMID- 20496849
OWN - NLM
STAT- MEDLINE
DCOM- 20100607
LR  - 20100525
IS  - 1029-4864 (Print)
IS  - 1029-4864 (Linking)
VI  - 65
IP  - 3
DP  - 2010 Apr
TI  - Ethics in dental practice: an overview--part 2.
PG  - 134-5
FAU - Moodley, K
AU  - Moodley K
AD  - Bioethics Unit-Tygerberg Division, University of Stellenbosch. km@sun.ac.za
FAU - Naidoo, S
AU  - Naidoo S
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - South Africa
TA  - SADJ
JT  - SADJ : journal of the South African Dental Association = tydskrif van die
      Suid-Afrikaanse Tandheelkundige Vereniging
JID - 9812497
MH  - Adolescent
MH  - Ethical Analysis
MH  - *Ethics, Dental
MH  - Female
MH  - Humans
MH  - Informed Consent/ethics
MH  - Patient Preference
MH  - Tooth Extraction/*ethics
EDAT- 2010/05/26 06:00
MHDA- 2010/06/09 06:00
CRDT- 2010/05/26 06:00
PHST- 2010/05/26 06:00 [entrez]
PHST- 2010/05/26 06:00 [pubmed]
PHST- 2010/06/09 06:00 [medline]
PST - ppublish
SO  - SADJ. 2010 Apr;65(3):134-5.


PMID- 20496814
OWN - NLM
STAT- MEDLINE
DCOM- 20100611
LR  - 20100525
IS  - 1682-8658 (Print)
IS  - 1682-8658 (Linking)
IP  - 2
DP  - 2010
TI  - [Medical ethics in the past, present and future].
PG  - 70-8
FAU - Petrovskii, B V
AU  - Petrovskii BV
LA  - rus
PT  - Historical Article
PT  - Journal Article
PL  - Russia (Federation)
TA  - Eksp Klin Gastroenterol
JT  - Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical
      gastroenterology
JID - 101144944
SB  - IM
MH  - Ethics, Medical/*history
MH  - History, 19th Century
MH  - History, 20th Century
MH  - History, 21st Century
MH  - History, Ancient
EDAT- 2010/05/26 06:00
MHDA- 2010/06/12 06:00
CRDT- 2010/05/26 06:00
PHST- 2010/05/26 06:00 [entrez]
PHST- 2010/05/26 06:00 [pubmed]
PHST- 2010/06/12 06:00 [medline]
PST - ppublish
SO  - Eksp Klin Gastroenterol. 2010;(2):70-8.


PMID- 20496608
OWN - NLM
STAT- MEDLINE
DCOM- 20100708
LR  - 20100525
IS  - 1082-6742 (Print)
IS  - 1082-6742 (Linking)
VI  - 24
IP  - 1
DP  - 2010 Mar
TI  - The ethics of exotic animal analgesia.
PG  - 72-6
FAU - Dutton, Michael A
AU  - Dutton MA
AD  - Exotic and Bird Clinic of New Hampshire, Weare, NH, USA.
FAU - Helmer, Peter
AU  - Helmer P
FAU - Kolmstetter, Christine
AU  - Kolmstetter C
FAU - Lavac, Frank
AU  - Lavac F
FAU - Mackensen, Christina
AU  - Mackensen C
FAU - Orcutt, Connie
AU  - Orcutt C
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Avian Med Surg
JT  - Journal of avian medicine and surgery
JID - 9512497
RN  - 0 (Analgesics)
SB  - IM
MH  - Analgesia/ethics/*veterinary
MH  - Analgesics/administration & dosage/*therapeutic use
MH  - Animals
MH  - Bird Diseases/*therapy
MH  - Birds
MH  - Pain/*drug therapy
MH  - Surgery, Veterinary/ethics
MH  - Veterinary Medicine/*ethics
EDAT- 2010/05/26 06:00
MHDA- 2010/07/09 06:00
CRDT- 2010/05/26 06:00
PHST- 2010/05/26 06:00 [entrez]
PHST- 2010/05/26 06:00 [pubmed]
PHST- 2010/07/09 06:00 [medline]
AID - 10.1647/1082-6742-24.1.72 [doi]
PST - ppublish
SO  - J Avian Med Surg. 2010 Mar;24(1):72-6. doi: 10.1647/1082-6742-24.1.72.


PMID- 20496523
OWN - NLM
STAT- MEDLINE
DCOM- 20100720
LR  - 20191210
IS  - 0738-0658 (Print)
IS  - 0738-0658 (Linking)
VI  - 29
IP  - 2
DP  - 2010 Jun
TI  - Knowledge and implementation of the DNR in internal medicine teaching programs.
PG  - 96-101
AB  - BACKGROUND: The knowledge and implementation skills of the DNR (do not
      resuscitate) order amongst physicians in training appears to be quite variable.
      METHODS: We constructed, validated and implemented an instrument which evaluates 
      knowledge and implementation skills of medical residents regarding the DNR in the
      8 accredited teaching hospitals in Puerto Rico. RESULTS: Participation of 136
      residents from 240 approved positions was seen. Most thought (93.3%) the DNR
      should be written in the medical record. And 88.1% thought appropriate to suggest
      a DNR to the patient or family for a terminally ill patient. For a patient with
      an uncertain prognosis who insisted on a DNR, 78.5% believed the attending
      physician and 21.5% thought the ethics committee was responsible for determining 
      the propriety of the order. When the patient and the treating physicians agreed
      on the appropriateness of a DNR order most residents in the North of Puerto Rico 
      thought the writing of the order was the purview of the resident while residents 
      in the South-West thought this to be the responsibility of the attending
      physician. In the absence of a DNR order, more than 77.4% of the residents in the
      North and South would initiate CPR in a comatose patient with terminal cancer,
      multiple organ failure and sepsis in contrast to 15% of the residents in the
      West. CONCLUSIONS: Implementation and knowledge skills of medical residents in
      the health regions of Puerto Rico differ. Knowledge and implementation of the DNR
      merits improvement in all training programs.
FAU - Ramirez-Rivera, Jose
AU  - Ramirez-Rivera J
AD  - Department of Medicine Ramon Ruiz Arnau Hospital and Universidad Central del
      Caribe PO Box 60327 Bayamon, PR. ramirez.r629@gmail.com
FAU - Canova-Diaz, Carlos
AU  - Canova-Diaz C
FAU - Hunter-Mellado, Robert
AU  - Hunter-Mellado R
LA  - eng
PT  - Journal Article
PT  - Validation Study
PL  - Puerto Rico
TA  - P R Health Sci J
JT  - Puerto Rico health sciences journal
JID - 8303541
SB  - IM
MH  - Adult
MH  - *Curriculum
MH  - Educational Measurement
MH  - Female
MH  - Humans
MH  - Internal Medicine/*education
MH  - *Internship and Residency
MH  - Male
MH  - *Resuscitation Orders
MH  - *Surveys and Questionnaires
EDAT- 2010/05/26 06:00
MHDA- 2010/07/21 06:00
CRDT- 2010/05/26 06:00
PHST- 2010/05/26 06:00 [entrez]
PHST- 2010/05/26 06:00 [pubmed]
PHST- 2010/07/21 06:00 [medline]
PST - ppublish
SO  - P R Health Sci J. 2010 Jun;29(2):96-101.


PMID- 20496436
OWN - NLM
STAT- MEDLINE
DCOM- 20100826
LR  - 20121115
IS  - 1935-9780 (Electronic)
IS  - 1935-9772 (Linking)
VI  - 3
IP  - 3
DP  - 2010 May-Jun
TI  - An education that pierces what the knife cannot: a student perspective.
PG  - 151-3
LID - 10.1002/ase.147 [doi]
AB  - If personalized medicine is the way of the future, and the physician's approach
      to each patient becomes more individualized and team-based, so must the
      professors' approach to the medical student experience. Mayo Medical School has
      an innovative curriculum designed to respect and enhance the individual interests
      of its students. A former educator herself, and now a medical student, the author
      advocates for further creative curriculum design to enhance healthy student
      attitude learning in medical school. In her personal testimony to the healing
      power of art and story, she cautions institutions that ignore integrating
      humanities into their curriculum that their student physicians will build
      self-protective barriers without self-reflection. She argues students must have
      more avenues to express their emotions during difficult transitions and ethical
      dilemmas. This commentary describes extracurricular student projects during
      anatomy, and includes an example of student reflective writing in anatomy. The
      author suggests that narrative medicine as an emerging discipline would be an
      effective educational strategy when applied to any aspect of the medical
      curriculum, and should be considered by more medical schools for further progress
      in medical education.
CI  - (c) 2010 American Association of Anatomists.
FAU - Hammer, Rachel R
AU  - Hammer RR
AD  - College of Medicine, Mayo Medical School, Mayo Clinic, 200 First Street SW,
      Rochester, MN 55905, USA. hammer.rachel@mayo.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Anat Sci Educ
JT  - Anatomical sciences education
JID - 101392205
SB  - IM
MH  - Anatomy/*education
MH  - Attitude
MH  - Creativity
MH  - *Curriculum
MH  - Education, Medical, Undergraduate/methods
MH  - Humanities/education
MH  - Humans
MH  - Learning
MH  - Narration
MH  - Students, Medical/psychology
EDAT- 2010/05/25 06:00
MHDA- 2010/08/27 06:00
CRDT- 2010/05/25 06:00
PHST- 2010/05/25 06:00 [entrez]
PHST- 2010/05/25 06:00 [pubmed]
PHST- 2010/08/27 06:00 [medline]
AID - 10.1002/ase.147 [doi]
PST - ppublish
SO  - Anat Sci Educ. 2010 May-Jun;3(3):151-3. doi: 10.1002/ase.147.


PMID- 20496223
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20201231
IS  - 1466-447X (Electronic)
IS  - 0264-0414 (Linking)
VI  - 28
IP  - 7
DP  - 2010 May
TI  - Understanding mental toughness in Australian soccer: perceptions of players,
      parents, and coaches.
PG  - 699-716
LID - 10.1080/02640411003734085 [doi]
AB  - We explored mental toughness in soccer using a triangulation of data capture
      involving players (n = 6), coaches (n = 4), and parents (n = 5). Semi-structured 
      interviews, based on a personal construct psychology (Kelly, 1955/1991)
      framework, were conducted to elicit participants' perspectives on the key
      characteristics and their contrasts, situations demanding mental toughness, and
      the behaviours displayed and cognitions employed by mentally tough soccer
      players. The results from the research provided further evidence that mental
      toughness is conceptually distinct from other psychological constructs such as
      hardiness. The findings also supported Gucciardi, Gordon, and Dimmock's (2009)
      process model of mental toughness. A winning mentality and desire was identified 
      as a key attribute of mentally tough soccer players in addition to other
      previously reported qualities such as self-belief, physical toughness, work
      ethic/motivation, and resilience. Key cognitions reported by mentally tough
      soccer players enabled them to remain focused and competitive during training and
      matches and highlighted the adoption of several forms of self-talk in dealing
      with challenging situations. Minor revisions to Gucciardi and colleagues'
      definition of mental toughness are proposed.
FAU - Coulter, Tristan J
AU  - Coulter TJ
AD  - School of Human Movement Studies, The University of Queensland, St. Lucia,
      Queensland, Australia.
FAU - Mallett, Clifford J
AU  - Mallett CJ
FAU - Gucciardi, Daniel F
AU  - Gucciardi DF
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Sports Sci
JT  - Journal of sports sciences
JID - 8405364
SB  - IM
MH  - Adult
MH  - Athletes/*psychology
MH  - Athletic Performance/*psychology
MH  - Australia
MH  - Competitive Behavior
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Models, Psychological
MH  - Parents/*psychology
MH  - *Perception
MH  - *Resilience, Psychological
MH  - Soccer/*psychology
EDAT- 2010/05/25 06:00
MHDA- 2010/09/15 06:00
CRDT- 2010/05/25 06:00
PHST- 2010/05/25 06:00 [entrez]
PHST- 2010/05/25 06:00 [pubmed]
PHST- 2010/09/15 06:00 [medline]
AID - 922457708 [pii]
AID - 10.1080/02640411003734085 [doi]
PST - ppublish
SO  - J Sports Sci. 2010 May;28(7):699-716. doi: 10.1080/02640411003734085.


PMID- 20496208
OWN - NLM
STAT- MEDLINE
DCOM- 20110127
LR  - 20171116
IS  - 1520-5711 (Electronic)
IS  - 1054-3406 (Linking)
VI  - 20
IP  - 4
DP  - 2010 Jul
TI  - Bayesian estimation for performance measures of two diagnostic tests in the
      presence of verification bias.
PG  - 821-34
LID - 10.1080/10543401003618868 [doi]
AB  - Sensitivity and specificity are measures that allow us to evaluate the
      performance of a diagnostic test. In practice, it is common to have situations
      where a proportion of selected individuals cannot have the real state of the
      disease verified, since the verification could be an invasive procedure, as
      occurs with biopsy. This happens, as a special case, in the diagnosis of prostate
      cancer, or in any other situation related to risks, that is, not practicable, nor
      ethical, or in situations with high cost. For this case, it is common to use
      diagnostic tests based only on the information of verified individuals. This
      procedure can lead to biased results or workup bias. In this paper, we introduce 
      a Bayesian approach to estimate the sensitivity and the specificity for two
      diagnostic tests considering verified and unverified individuals, a result that
      generalizes the usual situation based on only one diagnostic test.
FAU - Aragon, Davi Casale
AU  - Aragon DC
AD  - Department of Social Medicine, Medical School of Ribeirao Preto, University of
      Sao Paulo, Ribeirao Preto, Brazil.
FAU - Martinez, Edson Zangiacomi
AU  - Martinez EZ
FAU - Achcar, Jorge Alberto
AU  - Achcar JA
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Biopharm Stat
JT  - Journal of biopharmaceutical statistics
JID - 9200436
SB  - IM
MH  - Algorithms
MH  - *Bayes Theorem
MH  - *Bias
MH  - Computer Simulation
MH  - Diagnostic Tests, Routine/*methods/standards
MH  - Female
MH  - Humans
MH  - Likelihood Functions
MH  - Markov Chains
MH  - *Models, Statistical
MH  - Monte Carlo Method
MH  - Papillomavirus Infections/diagnosis
MH  - Sample Size
MH  - Sensitivity and Specificity
MH  - Uterine Cervical Neoplasms/diagnosis
MH  - Vaginal Smears
EDAT- 2010/05/25 06:00
MHDA- 2011/01/29 06:00
CRDT- 2010/05/25 06:00
PHST- 2010/05/25 06:00 [entrez]
PHST- 2010/05/25 06:00 [pubmed]
PHST- 2011/01/29 06:00 [medline]
AID - 922401911 [pii]
AID - 10.1080/10543401003618868 [doi]
PST - ppublish
SO  - J Biopharm Stat. 2010 Jul;20(4):821-34. doi: 10.1080/10543401003618868.


PMID- 20495265
OWN - NLM
STAT- MEDLINE
DCOM- 20101110
LR  - 20100524
IS  - 1529-8795 (Electronic)
IS  - 0031-5982 (Linking)
VI  - 53
IP  - 2
DP  - 2010 Spring
TI  - On first looking into Kutcher's "Contested Medicine": ethical tensions in
      clinical research.
PG  - 304-14
LID - 10.1353/pbm.0.0155 [doi]
AB  - Contested Medicine examines the experiments done at the University of Cincinnati 
      by Eugene Saenger and his colleagues during the 1960s, a time of great fear that 
      the Cold War between the United States and the Soviet Union would become a hot
      war using nuclear weapons. These studies were to provide the Department of
      Defense information relevant to the consequences of exposure of military
      personnel to ionizing radiation in such circumstances. Kutcher, a radiation
      physicist turned historian of science, is especially well prepared to put these
      studies into the context of the evolving bioethics of the time. He reviews the
      essential ethical reviews, beginning with the Nuremberg Code and extending to
      those of the Advisory Committee on Human Radiation Experiments appointed by
      President Clinton. These evolving ethical standards provide a cautionary note to 
      today's methods of clinical experimentation in search of proper evidence-based
      medicine. There has been an ascendance of the priority of patient rights over
      societal good except in increasingly limited special circumstances. Some of what 
      was considered good and necessary science in the 1960s and 1970s is no longer
      considered proper. Similarly, future ethical norms may well find current trial
      methodology to be flawed.
FAU - Hellman, Samuel
AU  - Hellman S
AD  - Department of Radiation and Cellular Oncology, University of Chicago, 5841 South 
      Maryland Avenue, MC 9006, Chicago, IL 60637-1470, USA. s-hellman@uchicago.edu
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - Perspect Biol Med
JT  - Perspectives in biology and medicine
JID - 0401132
SB  - IM
MH  - Ethics, Research/*history
MH  - History, 20th Century
MH  - Human Experimentation/ethics/*history
MH  - Humans
MH  - Informed Consent
MH  - Military Personnel/history
MH  - Neoplasms/history/radiotherapy
MH  - Ohio
MH  - *Radiation, Ionizing
MH  - Research Subjects
MH  - United States
MH  - Universities/history
EDAT- 2010/05/25 06:00
MHDA- 2010/11/11 06:00
CRDT- 2010/05/25 06:00
PHST- 2010/05/25 06:00 [entrez]
PHST- 2010/05/25 06:00 [pubmed]
PHST- 2010/11/11 06:00 [medline]
AID - S1529879510200108 [pii]
AID - 10.1353/pbm.0.0155 [doi]
PST - ppublish
SO  - Perspect Biol Med. 2010 Spring;53(2):304-14. doi: 10.1353/pbm.0.0155.


PMID- 20495258
OWN - NLM
STAT- MEDLINE
DCOM- 20101110
LR  - 20100524
IS  - 1529-8795 (Electronic)
IS  - 0031-5982 (Linking)
VI  - 53
IP  - 2
DP  - 2010 Spring
TI  - Contemplating cognitive enhancement in medical students and residents.
PG  - 200-14
LID - 10.1353/pbm.0.0154 [doi]
AB  - Medical school and residency can be stressful times, involving years of intensive
      academic study and pressure to earn high grades. Students and residents must
      learn to care for the sick, a task requiring long work hours and sleep
      deprivation. In such an environment, it is important to monitor the mental health
      of trainees and the factors that influence it. This essay examines a relatively
      unexplored facet of physician mental health: the use of pharmacological
      stimulants by students and residents to study better, earn higher grades, stay
      awake longer, and take better care of patients. Practical and ethical
      considerations of stimulant use in the medical profession, along with future
      directions for medical student mental health, are discussed.
FAU - Webb, Jadon R
AU  - Webb JR
AD  - Medical Scientist Training Program, University of Texas Southwestern Medical
      Center, Dallas, TX 75390, USA. jwebb1@parknet.pmh.org
FAU - Thomas, John W
AU  - Thomas JW
FAU - Valasek, Mark A
AU  - Valasek MA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Perspect Biol Med
JT  - Perspectives in biology and medicine
JID - 0401132
RN  - 0 (Central Nervous System Stimulants)
SB  - IM
MH  - *Adaptation, Psychological
MH  - Central Nervous System Stimulants/*pharmacology
MH  - *Cognition
MH  - Decision Making
MH  - Education, Medical
MH  - Humans
MH  - *Internship and Residency
MH  - Sleep Deprivation
MH  - Stress, Psychological
MH  - Students, Medical/*psychology
EDAT- 2010/05/25 06:00
MHDA- 2010/11/11 06:00
CRDT- 2010/05/25 06:00
PHST- 2010/05/25 06:00 [entrez]
PHST- 2010/05/25 06:00 [pubmed]
PHST- 2010/11/11 06:00 [medline]
AID - S1529879510200030 [pii]
AID - 10.1353/pbm.0.0154 [doi]
PST - ppublish
SO  - Perspect Biol Med. 2010 Spring;53(2):200-14. doi: 10.1353/pbm.0.0154.


PMID- 20495256
OWN - NLM
STAT- MEDLINE
DCOM- 20101110
LR  - 20100524
IS  - 1529-8795 (Electronic)
IS  - 0031-5982 (Linking)
VI  - 53
IP  - 2
DP  - 2010 Spring
TI  - Ethics of responsibility in a multicultural context.
PG  - 174-85
LID - 10.1353/pbm.0.0150 [doi]
AB  - Caring for patients from different cultural or religious backgrounds may create
      difficult ethical dilemmas for physicians. The article reviews four case
      histories, involving patients from the Navajo culture or the Christian Science
      Church, that highlight some of these ethical problems. It then discusses an
      "ethics of responsibility," which is based on and encompasses a variety of
      meanings of responsibility, including responsibility as recognition, as taking
      charge, as the ability to assess the consequences of one's actions, and as making
      a commitment. An ethics of responsibility provides a novel perspective for
      resolving ethical problems in medicine.
FAU - Turoldo, Fabrizio
AU  - Turoldo F
AD  - Department of Philosophy and Theory of Sciences, Ca' Foscari University, Palazzo 
      Marcora-Malcanton, Dorsoduro 3484, 30123 Venice, Italy. fturoldo@unive.it
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Perspect Biol Med
JT  - Perspectives in biology and medicine
JID - 0401132
SB  - IM
MH  - Christian Science
MH  - *Ethics, Medical
MH  - Humans
MH  - Indians, North American
MH  - Physician-Patient Relations/*ethics
MH  - Religion and Medicine
MH  - *Social Responsibility
EDAT- 2010/05/25 06:00
MHDA- 2010/11/11 06:00
CRDT- 2010/05/25 06:00
PHST- 2010/05/25 06:00 [entrez]
PHST- 2010/05/25 06:00 [pubmed]
PHST- 2010/11/11 06:00 [medline]
AID - S1529879510200017 [pii]
AID - 10.1353/pbm.0.0150 [doi]
PST - ppublish
SO  - Perspect Biol Med. 2010 Spring;53(2):174-85. doi: 10.1353/pbm.0.0150.


PMID- 20495255
OWN - NLM
STAT- MEDLINE
DCOM- 20101110
LR  - 20100524
IS  - 1529-8795 (Electronic)
IS  - 0031-5982 (Linking)
VI  - 53
IP  - 2
DP  - 2010 Spring
TI  - Pragmatic problems with clinical equipoise.
PG  - 161-73
LID - 10.1353/pbm.0.0161 [doi]
AB  - It is widely accepted that if one is to follow the ethical tenets of clinical
      equipoise, phase III controlled clinical trials must be designed pragmatically,
      to measure effectiveness rather than efficacy. This choice of a pragmatic rather 
      than an explanatory approach to phase III clinical trial design has a number of
      consequences, some of which may be considered problematic. These include changes 
      in what the trial is expected to accomplish, the way treatments are defined, the 
      selection of subjects, the ways in which treatments are compared, and the
      assessment of the results. One also may end up challenging the real-world
      expectation that scientific results will be replicated before they are considered
      valid. This article discusses the connection between clinical equipoise and
      pragmatic trials, contrasts explanatory with pragmatic trials, points to the
      differences in the ways in which trial data are analyzed and interpreted, and
      discusses the power of replication, one of the defining hallmarks of the
      scientific method. Viewing clinical equipoise through a consequentialist lens
      reveals a number of problems, many of which are attributable to equipoise's
      insistence on a pragmatic approach to trial architecture.
FAU - Kowalski, Charles J
AU  - Kowalski CJ
AD  - University of Michigan, Institutional Review Board, Health Sciences/Behavioral
      Sciences, 540 East Liberty Street, Suite 202, Ann Arbor, MI 48104-2210, USA.
      chuckk@umich.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Perspect Biol Med
JT  - Perspectives in biology and medicine
JID - 0401132
SB  - IM
MH  - *Clinical Trials, Phase III as Topic/ethics/methods
MH  - Decision Making
MH  - Humans
MH  - Patient Selection
MH  - Treatment Outcome
EDAT- 2010/05/25 06:00
MHDA- 2010/11/11 06:00
CRDT- 2010/05/25 06:00
PHST- 2010/05/25 06:00 [entrez]
PHST- 2010/05/25 06:00 [pubmed]
PHST- 2010/11/11 06:00 [medline]
AID - S1529879510200005 [pii]
AID - 10.1353/pbm.0.0161 [doi]
PST - ppublish
SO  - Perspect Biol Med. 2010 Spring;53(2):161-73. doi: 10.1353/pbm.0.0161.


PMID- 20494041
OWN - NLM
STAT- MEDLINE
DCOM- 20100616
LR  - 20161125
IS  - 1552-6259 (Electronic)
IS  - 0003-4975 (Linking)
VI  - 89
IP  - 6
DP  - 2010 Jun
TI  - Echocardiographic identification of iatrogenic injury of the circumflex artery
      during minimally invasive mitral valve repair.
PG  - 1866-72
LID - 10.1016/j.athoracsur.2010.02.059 [doi]
AB  - BACKGROUND: Injury to the circumflex artery after mitral valve (MV) repair or
      replacement is a recognized complication of this procedure. We designed an
      echocardiographic method to visualize the course and flow of the circumflex
      artery, to detect iatrogenic injury to this structure intraoperatively, as well
      as to predict the coronary dominance pattern in MV surgery patients. METHODS:
      After Ethics Committee approval, a prospective study was undertaken in 110
      patients undergoing minimal invasive MV repair. Intraoperative transesophageal
      echocardiography was used to visualize the circumflex artery using a combination 
      of B-mode imaging and color Doppler with different Nyquist limits. The course of 
      the circumflex artery and the coronary sinus and their corresponding diameters
      were documented at the proximal and distal ends of both vessels. Preoperative
      angiographic data were used to determine the coronary dominance type. RESULTS:
      The course of the circumflex artery could be detected proximally in 109 patients 
      (99%), to the point of intersection with the coronary sinus in 99 patients (90%),
      and distal to this intersection in 95 patients (86%) using our technique. Three
      patients had evidence of iatrogenic aliasing (circumflex stenosis) or "no flow"
      (circumflex occlusion) on transesophageal echocardiography examination after
      repair and therefore underwent surgical or percutaneous correction. All 3 of
      these patients had an uncomplicated postoperative course thereafter with no
      evidence of perioperative myocardial infarction. All remaining patients with
      normal circumflex examinations after repair did not show any clinical evidence of
      myocardial infarction or unstable hemodynamics postoperatively. The 95%
      confidence interval for the diameter of the proximal circumflex artery was 4.5 mm
      to 5.6 mm for the left dominant type patients and 3.8 mm to 4.2 mm for the right 
      dominant and balanced type patients (p = 0.01). CONCLUSIONS: The early
      recognition of iatrogenic injury of the circumflex artery is feasible with
      intraoperative transesophageal echocardiography examination, and may lead to
      treatment before extensive myocardial infarction occurs. We suggest that
      visualization of the circumflex artery with our technique should be performed
      more frequently in patients undergoing MV surgery.
CI  - 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights
      reserved.
FAU - Ender, Joerg
AU  - Ender J
AD  - Department of Anesthesiology and Intensive Care Medicine II, Heart Center
      Leipzig, University of Leipzig, Leipzig, Germany.
      joerg.ender@medizin.uni-leipzig.de
FAU - Selbach, Michael
AU  - Selbach M
FAU - Borger, Michael A
AU  - Borger MA
FAU - Krohmer, Eugen
AU  - Krohmer E
FAU - Falk, Volkmar
AU  - Falk V
FAU - Kaisers, Udo X
AU  - Kaisers UX
FAU - Mohr, Friedrich W
AU  - Mohr FW
FAU - Mukherjee, Chirojit
AU  - Mukherjee C
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Ann Thorac Surg
JT  - The Annals of thoracic surgery
JID - 15030100R
SB  - IM
MH  - Coronary Vessels/anatomy & histology/*diagnostic imaging/*injuries
MH  - *Echocardiography, Transesophageal
MH  - Female
MH  - Humans
MH  - Iatrogenic Disease
MH  - Intraoperative Complications/*diagnostic imaging
MH  - Male
MH  - Middle Aged
MH  - Minimally Invasive Surgical Procedures
MH  - Mitral Valve/*surgery
MH  - Prospective Studies
MH  - Ultrasonography, Doppler, Color
EDAT- 2010/05/25 06:00
MHDA- 2010/06/17 06:00
CRDT- 2010/05/25 06:00
PHST- 2009/11/16 00:00 [received]
PHST- 2010/02/15 00:00 [revised]
PHST- 2010/02/17 00:00 [accepted]
PHST- 2010/05/25 06:00 [entrez]
PHST- 2010/05/25 06:00 [pubmed]
PHST- 2010/06/17 06:00 [medline]
AID - S0003-4975(10)00445-5 [pii]
AID - 10.1016/j.athoracsur.2010.02.059 [doi]
PST - ppublish
SO  - Ann Thorac Surg. 2010 Jun;89(6):1866-72. doi: 10.1016/j.athoracsur.2010.02.059.


PMID- 20493643
OWN - NLM
STAT- MEDLINE
DCOM- 20101206
LR  - 20140812
IS  - 1773-0430 (Electronic)
IS  - 0150-9918 (Linking)
VI  - 39
IP  - 5
DP  - 2010 Sep
TI  - [Institutional review board of the French college of obstetricians and
      gynecologists (CEROG).].
PG  - 401-8
LID - 10.1016/j.jgyn.2009.12.009 [doi]
AB  - OBJECTIVE: To report the rules and the activity of the institutional review board
      of the French college of obstetricians and gynecologists (Comite d'ethique de la 
      recherche en obstetrique et gynecologie [CEROG]) created in 2008. The submission 
      requirements are also described. METHODS: Retrospective study. RESULTS: The
      Ethical Review Committee [institutional review board of the French college of
      obstetricians and gynecologists (CNGOF)] CEROG have examined 65 project studies
      in 2008. The median number of submitted studies was 5.5 per month (IQR:
      3.75-6.25). The origins of the submission were as follows: tertiary care
      university hospitals (n=63, 97 %), Inserm (n=1), INRA (n=1). Researches were
      found to be in conformity with the French laws and regulations, to conform to
      generally accepted scientific principles and medical research ethical standards
      in 44 cases (68 %). In 13 cases (20 %), the study has been forwarded to the
      Persons Protection Committee (PPC) since it concerned biomedical research or
      "usual care research" (soin courant). In six cases (9 %), the investigators have 
      not responded to IRB suggestions. In two cases (3 %), the information form has
      been judged unsatisfactory. CONCLUSION: The CEROG is the first national IRB in
      obstetrics and gynecology. This new committee clarifies IRB submission procedure 
      in France concerning non-interventional studies in the field of obstetrics and
      gynecology.
CI  - Copyright 2010 Elsevier Masson SAS. All rights reserved.
FAU - Deffieux, X
AU  - Deffieux X
AD  - College national des gynecologues et obstetriciens francais, 184, rue du
      Faubourg-Saint-Antoine, 75012 Paris, France. xavier.deffieux@abc.ap-hop-paris.fr
FAU - Vayssiere, C
AU  - Vayssiere C
FAU - Azria, E
AU  - Azria E
FAU - Porcher, R
AU  - Porcher R
FAU - Parant, O
AU  - Parant O
FAU - Clavier, J
AU  - Clavier J
FAU - Guibert, J
AU  - Guibert J
FAU - Benachi, A
AU  - Benachi A
FAU - Houfflin-Debarge, V
AU  - Houfflin-Debarge V
FAU - Jouannic, J-M
AU  - Jouannic JM
FAU - Rozenberg, P
AU  - Rozenberg P
FAU - Andre, G
AU  - Andre G
FAU - Ansquer, Y
AU  - Ansquer Y
FAU - Rouzier, R
AU  - Rouzier R
FAU - Benbassa, A
AU  - Benbassa A
FAU - Collinet, P
AU  - Collinet P
FAU - Ayel, J-P
AU  - Ayel JP
FAU - Jacquetin, B
AU  - Jacquetin B
FAU - Morice, P
AU  - Morice P
FAU - Boubli, L
AU  - Boubli L
FAU - Senat, M-V
AU  - Senat MV
FAU - Brunet, L
AU  - Brunet L
FAU - Levy, G
AU  - Levy G
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Le Comite d'ethique de la recherche en obstetrique et gynecologie (CEROG).
DEP - 20100520
PL  - France
TA  - J Gynecol Obstet Biol Reprod (Paris)
JT  - Journal de gynecologie, obstetrique et biologie de la reproduction
JID - 0322206
SB  - IM
MH  - Biomedical Research/ethics/legislation & jurisprudence
MH  - *Ethics Committees, Research/organization & administration
MH  - France
MH  - *Gynecology
MH  - *Obstetrics
EDAT- 2010/05/25 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/05/25 06:00
PHST- 2009/05/17 00:00 [received]
PHST- 2009/06/30 00:00 [revised]
PHST- 2009/12/24 00:00 [accepted]
PHST- 2010/05/25 06:00 [entrez]
PHST- 2010/05/25 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S0368-2315(10)00128-6 [pii]
AID - 10.1016/j.jgyn.2009.12.009 [doi]
PST - ppublish
SO  - J Gynecol Obstet Biol Reprod (Paris). 2010 Sep;39(5):401-8. doi:
      10.1016/j.jgyn.2009.12.009. Epub 2010 May 20.


PMID- 20493578
OWN - NLM
STAT- MEDLINE
DCOM- 20110328
LR  - 20220408
IS  - 1872-8332 (Electronic)
IS  - 0169-5002 (Linking)
VI  - 71
IP  - 1
DP  - 2011 Jan
TI  - The safety and efficacy of weekly paclitaxel in combination with carboplatin for 
      advanced non-small cell lung cancer with idiopathic interstitial pneumonias.
PG  - 70-4
LID - 10.1016/j.lungcan.2010.04.014 [doi]
AB  - BACKGROUND: Idiopathic interstitial pneumonias (IIPs) are one of the most common 
      complications in patients with lung cancer. In lung cancer patients with IIP, the
      most serious toxicity is acute exacerbation of IIP caused by anticancer treatment
      in Japan. However, there has been no consensus and no evidence presented,
      regarding optimal treatment for advanced lung cancer with IIP. PATIENTS AND
      METHODS: Chemotherapy-naive patients of inoperable stage, or post-operative
      recurrent non-small cell lung cancer (NSCLC) with IIPs were enrolled. Patients
      received paclitaxel at a dose of 100mg/m(2) on Days 1, 8, 15, and carboplatin
      every 28 days at a target dose of area under the curve (AUC) 5.0 on Day 1.
      RESULTS: Between May 2004 and October 2008, 18 patients, including 6 with
      idiopathic pulmonary fibrosis (IPF), were enrolled and treated for a median of
      four cycles (range, 1-6). One patient (5.6%; 95% confidence interval (CI), 0-17%)
      with histologically confirmed IPF had acute exacerbation of IIPs associated with 
      the treatment. The overall response rate was 61% (95% CI, 36-86%). The median
      progression-free survival, median survival time, and 1-year survival rate were
      5.3 months, 10.6 months, and 22%, respectively. CONCLUSION: This is the first
      report indicating that advanced NSCLC patients with IIP may benefit from
      chemotherapy. Weekly paclitaxel and carboplatin combination chemotherapy was as
      effective as conventional regimens in advanced NSCLC patients without IIP and was
      safer than previously reported for NSCLC patients with IIP. The results from this
      study would support, on ethical grounds, the conduct of a large-scale study to
      confirm the feasibility of this regimen.
CI  - Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Minegishi, Yuji
AU  - Minegishi Y
AD  - Division of Pulmonary Medicine, Infectious Disease, and Oncology, Department of
      Internal Medicine, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-ku, Tokyo
      113-8602, Japan. yminegis@nms.ac.jp
FAU - Sudoh, Junko
AU  - Sudoh J
FAU - Kuribayasi, Hideaki
AU  - Kuribayasi H
FAU - Mizutani, Hideki
AU  - Mizutani H
FAU - Seike, Masahiro
AU  - Seike M
FAU - Azuma, Arata
AU  - Azuma A
FAU - Yoshimura, Akinobu
AU  - Yoshimura A
FAU - Kudoh, Shoji
AU  - Kudoh S
FAU - Gemma, Akihiko
AU  - Gemma A
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100520
PL  - Ireland
TA  - Lung Cancer
JT  - Lung cancer (Amsterdam, Netherlands)
JID - 8800805
RN  - BG3F62OND5 (Carboplatin)
RN  - P88XT4IS4D (Paclitaxel)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antineoplastic Combined Chemotherapy Protocols/*administration & dosage/adverse
      effects
MH  - Carboplatin/administration & dosage/adverse effects
MH  - Carcinoma, Non-Small-Cell Lung/complications/*drug therapy
MH  - Disease-Free Survival
MH  - Drug Administration Schedule
MH  - Female
MH  - Humans
MH  - Idiopathic Interstitial Pneumonias/*complications
MH  - Lung Neoplasms/complications/*drug therapy
MH  - Male
MH  - Middle Aged
MH  - Paclitaxel/administration & dosage/adverse effects
MH  - Retrospective Studies
EDAT- 2010/05/25 06:00
MHDA- 2011/03/29 06:00
CRDT- 2010/05/25 06:00
PHST- 2010/01/23 00:00 [received]
PHST- 2010/03/24 00:00 [revised]
PHST- 2010/04/11 00:00 [accepted]
PHST- 2010/05/25 06:00 [entrez]
PHST- 2010/05/25 06:00 [pubmed]
PHST- 2011/03/29 06:00 [medline]
AID - S0169-5002(10)00173-X [pii]
AID - 10.1016/j.lungcan.2010.04.014 [doi]
PST - ppublish
SO  - Lung Cancer. 2011 Jan;71(1):70-4. doi: 10.1016/j.lungcan.2010.04.014. Epub 2010
      May 20.


PMID- 20491875
OWN - NLM
STAT- MEDLINE
DCOM- 20101221
LR  - 20101102
IS  - 1528-1167 (Electronic)
IS  - 0013-9580 (Linking)
VI  - 51
IP  - 10
DP  - 2010 Oct
TI  - When clinical trials make history: demonstrating efficacy of new antiepileptic
      drugs as monotherapy.
PG  - 1933-5
LID - 10.1111/j.1528-1167.2010.02589.x [doi]
AB  - Regulatory requirements to demonstrate the efficacy of novel antiepileptic drugs 
      (AEDs) as monotherapy differ between Europe and the United States. European
      regulators require a comparison with an established, optimally dosed AED,
      typically using a noninferiority design, whereas the U.S. Food and Drug
      Administration (FDA) demands demonstration of superiority versus a comparator.
      Because placebo cannot be used as sole therapy and it is unrealistic to expect
      that a new AED will be more efficacious than established agents at full dosages, 
      superiority monotherapy trials in epilepsy have traditionally relied on inclusion
      of controls treated with a suboptimal (low-dose) comparator. In the most common
      design, refractory patients are randomized to conversion to monotherapy with a
      full dose of the investigational agent or a low-dose active control, and are
      required to exit the trial if seizures deteriorate. Efficacy is demonstrated when
      exit rates are lower in the full-dose group than in controls. Although this
      design is efficient in demonstrating superiority, the use of suboptimal
      treatments has been increasingly criticized on ethical grounds. A meta-analysis
      has now demonstrated that patients randomized to suboptimal treatments in all
      previous trials had similar outcomes, thereby allowing the build up of a dataset 
      of historical controls against which response to investigational AEDs can be
      compared in future trials. Use of historical controls has been accepted by the
      FDA, subject to compliance with rigorous methodologic requirements. Although the 
      avoidance of suboptimal treatments in future trials is a welcome development, the
      conversion-to-monotherapy design is still far from being fully satisfactory and
      is not exempt from methodologic concerns.
CI  - Wiley Periodicals, Inc. (c) 2010 International League Against Epilepsy.
FAU - Perucca, Emilio
AU  - Perucca E
AD  - Clinical Pharmacology Unit, University of Pavia, and Clinical Trial Center,
      Institute of Neurology IRCCS C. Mondino Foundation, Pavia, Italy.
      perucca@unipv.it
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Epilepsia
JT  - Epilepsia
JID - 2983306R
RN  - 0 (Anticonvulsants)
RN  - 0 (Drugs, Investigational)
SB  - IM
MH  - Anticonvulsants/administration & dosage/*therapeutic use
MH  - *Control Groups
MH  - Controlled Clinical Trials as Topic/methods/*standards
MH  - Drug Approval
MH  - Drugs, Investigational/administration & dosage/*therapeutic use
MH  - Epilepsy/*drug therapy
MH  - European Union
MH  - Humans
MH  - Research Design/*standards
MH  - Treatment Outcome
MH  - United States
MH  - United States Food and Drug Administration/standards
EDAT- 2010/05/25 06:00
MHDA- 2010/12/22 06:00
CRDT- 2010/05/25 06:00
PHST- 2010/05/25 06:00 [entrez]
PHST- 2010/05/25 06:00 [pubmed]
PHST- 2010/12/22 06:00 [medline]
AID - EPI2589 [pii]
AID - 10.1111/j.1528-1167.2010.02589.x [doi]
PST - ppublish
SO  - Epilepsia. 2010 Oct;51(10):1933-5. doi: 10.1111/j.1528-1167.2010.02589.x.


PMID- 20491409
OWN - NLM
STAT- MEDLINE
DCOM- 20100721
LR  - 20100524
IS  - 1379-1176 (Print)
IS  - 1379-1176 (Linking)
VI  - 75
IP  - 1
DP  - 2010
TI  - Standardization of doctoral study in agricultural and extension education: is the
      field of study mature enough for achievement of the optimum degree of order?
PG  - 153-73
AB  - Agricultural and extension education--or some derivative name--is a field of
      study leading to the doctoral degree in universities around the world. Is there
      are body of knowledge or a taxonomy of the knowledge--e.g., a knowledge
      domain--that one should possess with a doctorate in agricultural and extension
      education? The purpose of this paper was to synthesize the work of researchers
      who attempted to define the field of study, with a taxonomy comprising the
      knowledge domains (standards) and knowledge objects--structured interrelated sets
      of data, knowledge, and wisdom--of the field of study. Doctoral study in
      agricultural and extension education needs a document that provides for rules and
      guidelines--rules and guidelines that in turn provide for common and repeated
      use--all leading to achievement of an optimum degree of order in the context of
      academic, scholarly, and professional practice in agricultural and extension
      education. Thus, one would know in broad categories the knowledge, skills, and
      abilities possessed by one who holds a doctoral degree in agricultural and
      extension education. That is, there would exist a standard for doctoral degrees
      in agricultural and extension education. A content analysis of three previous
      attempts to categorize knowledge in agricultural and extension education served
      as the primary technique to create a new taxonomy--or to confirm an existing
      taxonomy--for doctoral study in agricultural and extension education. The
      following coalesced as nine essential knowledge domains for a doctorate in
      agricultural and extension education: (1) history, philosophy, ethics, and
      policy; (2) agricultural/rural development; (3) organizational development and
      change management; (4) planning, needs assessment, and evaluation; (5) learning
      theory; (6) curriculum development and instructional design; (7) teaching methods
      and delivery strategies; (8) research methods and tools; and, (9) scholarship and
      communications.
FAU - Briers, G E
AU  - Briers GE
AD  - Texas A&M University, College of Agriculture and Life Sciences, Department of
      Agricultural Leadership, Education, and Communications, 2116 TAMU, College
      Station, Texas 77843-2116, USA.
FAU - Lindner, J R
AU  - Lindner JR
FAU - Shinn, G C
AU  - Shinn GC
FAU - Wingenbach, G W
AU  - Wingenbach GW
FAU - Baker, M T
AU  - Baker MT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Belgium
TA  - Commun Agric Appl Biol Sci
JT  - Communications in agricultural and applied biological sciences
JID - 101200320
SB  - IM
MH  - Agriculture/*education
MH  - Biological Science Disciplines/education
MH  - *Curriculum
MH  - Education, Graduate/*organization & administration/*standards
MH  - Internationality
MH  - Professional Competence
MH  - Universities/*organization & administration/*standards
EDAT- 2010/05/25 06:00
MHDA- 2010/07/22 06:00
CRDT- 2010/05/25 06:00
PHST- 2010/05/25 06:00 [entrez]
PHST- 2010/05/25 06:00 [pubmed]
PHST- 2010/07/22 06:00 [medline]
PST - ppublish
SO  - Commun Agric Appl Biol Sci. 2010;75(1):153-73.


PMID- 20490955
OWN - NLM
STAT- MEDLINE
DCOM- 20110311
LR  - 20211020
IS  - 1936-3567 (Electronic)
IS  - 1932-4502 (Linking)
VI  - 44
IP  - 4
DP  - 2010 Dec
TI  - Three approaches to the disjunction between psychological measurement and
      psychological persons: methodological and ethical considerations.
PG  - 299-309
LID - 10.1007/s12124-010-9129-4 [doi]
AB  - In this paper, we take forward Schwarz's (2009) disjunction between
      measurement-apparatus-questionnaire and measurement-apparatus-man to examine how 
      the crisis in contemporary psychology is related to assumptions about two sets of
      connections in research: connections between research tools, research behaviours,
      and psychological phenomena; and connections between researchers and researchees.
      By setting up a research problem with methodological and ethical implications, we
      describe three approaches that involve different assumptions and research
      activities in relation to the ways each makes these connections: Disassociated,
      Conventionally Connected and Persons in Dialogue Approaches. We argue that a
      Persons in Dialogue Approach is the most appropriate approach for a 21st Century 
      psychology in crisis.
FAU - Lawrence, Jeanette A
AU  - Lawrence JA
AD  - The University of Melbourne, Melbourne, Victoria, Australia.
      lawrence@unimelb.edu.au
FAU - Dodds, Agnes E
AU  - Dodds AE
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Integr Psychol Behav Sci
JT  - Integrative psychological & behavioral science
JID - 101319534
SB  - IM
CON - Integr Psychol Behav Sci. 2009 Sep;43(3):185-213. PMID: 19330558
MH  - Behavioral Research/ethics/*methods/standards
MH  - *Ethics, Research
MH  - Human Experimentation/ethics/standards
MH  - Humans
MH  - Mental Disorders/psychology
MH  - Models, Psychological
MH  - Psychometrics/ethics/*methods/standards
EDAT- 2010/05/22 06:00
MHDA- 2011/03/12 06:00
CRDT- 2010/05/22 06:00
PHST- 2010/05/22 06:00 [entrez]
PHST- 2010/05/22 06:00 [pubmed]
PHST- 2011/03/12 06:00 [medline]
AID - 10.1007/s12124-010-9129-4 [doi]
PST - ppublish
SO  - Integr Psychol Behav Sci. 2010 Dec;44(4):299-309. doi: 10.1007/s12124-010-9129-4.


PMID- 20490621
OWN - NLM
STAT- MEDLINE
DCOM- 20100928
LR  - 20211020
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 22
IP  - 1
DP  - 2010 Mar
TI  - Echo calling narcissus: what exceeds the gaze of clinical ethics consultation?
PG  - 73-84
LID - 10.1007/s10730-010-9123-8 [doi]
AB  - Guiding our response in this essay is our view that current efforts to demarcate 
      the role of the clinical ethicist risk reducing its complex network of
      authorizations to sites of power and payment. In turn, the role becomes
      susceptible to various ideologies-individualisms, proceduralisms,
      secularisms-that further divide the body from the web of significances that
      matter to that body, where only she, the patient, is located. The security of
      policy, standards, and employment will pull against and eventually sever the
      authorization secured by authentic moral inquiry. Instead of asking "What do I
      need to know?", the question animating the drive to standardize will be "What is 
      the policy or standard?" The claims of the authors in this issue of HEC Forum
      confirm these suspicions.
FAU - Bishop, Jeffrey P
AU  - Bishop JP
AD  - Center for Biomedical Ethics and Society, Vanderbilt University, Nashville, TN
      37203, USA. jeffrey.bishop@vanderbilt.edu
FAU - Fanning, Joseph B
AU  - Fanning JB
FAU - Bliton, Mark J
AU  - Bliton MJ
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
EIN - HEC Forum. 2010 Jun;22(2):171
MH  - *Credentialing
MH  - Ethicists/*standards
MH  - Ethics Consultation/*standards
MH  - Humans
MH  - *Professional Role
MH  - Reference Standards
MH  - United States
EDAT- 2010/05/22 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/05/22 06:00
PHST- 2010/05/22 06:00 [entrez]
PHST- 2010/05/22 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - 10.1007/s10730-010-9123-8 [doi]
PST - ppublish
SO  - HEC Forum. 2010 Mar;22(1):73-84. doi: 10.1007/s10730-010-9123-8.


PMID- 20488729
OWN - NLM
STAT- MEDLINE
DCOM- 20101216
LR  - 20211203
IS  - 1557-3117 (Electronic)
IS  - 1053-2498 (Linking)
VI  - 29
IP  - 8
DP  - 2010 Aug
TI  - Pig heart xenotransplantation as a bridge to allotransplantation.
PG  - 838-40
LID - 10.1016/j.healun.2010.03.017 [doi]
AB  - With the increasing availability of pigs genetically engineered to protect their 
      tissues from the human immune response, research into xenotransplantation is
      progressing steadily. One potential route to the clinic would be the use of a pig
      heart as a bridge to allotransplantation. This would only be ethical if the
      outcome was realistically estimated to be as good as, or better than, bridging
      with a mechanical device. The experimental results that would be required to
      warrant consideration of a clinical trial and the patients in whom bridging with 
      a xenograft might be considered preferable to a mechanical device are discussed.
CI  - Copyright (c) 2010 International Society for Heart and Lung Transplantation.
      Published by Elsevier Inc. All rights reserved.
FAU - Cooper, David K C
AU  - Cooper DK
AD  - Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical
      Center, Pittsburgh, Pennsylvania 15261, USA. cooperdk@upmc.edu
FAU - Teuteberg, Jeffrey J
AU  - Teuteberg JJ
LA  - eng
PT  - Journal Article
DEP - 20100520
PL  - United States
TA  - J Heart Lung Transplant
JT  - The Journal of heart and lung transplantation : the official publication of the
      International Society for Heart Transplantation
JID - 9102703
SB  - IM
MH  - Animals
MH  - Heart Transplantation/immunology/*trends
MH  - Heart-Assist Devices
MH  - Humans
MH  - Immunosuppression Therapy
MH  - Patient Selection
MH  - Primates
MH  - Swine
MH  - Transplantation, Heterologous/immunology/*trends
MH  - Transplantation, Homologous
EDAT- 2010/05/22 06:00
MHDA- 2010/12/17 06:00
CRDT- 2010/05/22 06:00
PHST- 2010/03/04 00:00 [received]
PHST- 2010/03/26 00:00 [revised]
PHST- 2010/03/30 00:00 [accepted]
PHST- 2010/05/22 06:00 [entrez]
PHST- 2010/05/22 06:00 [pubmed]
PHST- 2010/12/17 06:00 [medline]
AID - S1053-2498(10)00233-0 [pii]
AID - 10.1016/j.healun.2010.03.017 [doi]
PST - ppublish
SO  - J Heart Lung Transplant. 2010 Aug;29(8):838-40. doi:
      10.1016/j.healun.2010.03.017. Epub 2010 May 20.


PMID- 20488477
OWN - NLM
STAT- MEDLINE
DCOM- 20100728
LR  - 20131121
IS  - 1527-3792 (Electronic)
IS  - 0022-5347 (Linking)
VI  - 184
IP  - 1
DP  - 2010 Jul
TI  - Construction and evaluation of an anatomically correct multi-image modality
      compatible phantom for prostate cancer focal ablation.
PG  - 352-7
LID - 10.1016/j.juro.2010.03.001 [doi]
AB  - PURPOSE: Focal therapy using lasers is emerging as an alternative strategy for
      prostate cancer treatment. However, to our knowledge no anatomically correct
      models are available to test imaging and ablation techniques. Animal models
      present ethical, anatomical and cost challenges. We designed and validated an
      inexpensive but anatomically correct prostate phantom incorporating tumor, rectum
      and urethra that can be used for simulated and experimental magnetic resonance
      guided focal intervention. Our secondary aim was to asses the phantom using other
      imaging modalities. MATERIALS AND METHODS: The phantom, which was constructed of 
      ballistic gel, includes an 80 gm prostate with urethra, tumor, perineum and
      rectum. Gadolinium was added to make the gel visible to magnetic resonance
      imaging. To recreate a tumor an irregularly shaped 5 cc volume of coagulable gel 
      was inserted into the prostate phantom. The phantom was evaluated using magnetic 
      resonance, computerized tomography and transrectal ultrasound. Thermal ablation
      was delivered via interstitial placement of laser fibers. Magnetic resonance
      thermometry was done to record real-time tissue temperatures during thermal
      ablation. RESULTS: With all modalities tested the phantom emulated human prostate
      anatomy. The coagulable gel tumor allowed us to generate focal thermal lesions.
      The phantom had magnetic resonance imaging properties comparable to in vivo
      properties, allowing ablative zones to be accurately assessed and magnetic
      resonance thermometry to be done. CONCLUSIONS: The phantom is a useful tool to
      test different aspects of thermal focal ablation for prostate cancer using
      multiple imaging modalities, particularly magnetic resonance. It is inexpensive
      and easily constructed, and may be considered a valuable model to train on and
      teach focal therapy.
CI  - Copyright (c) 2010 American Urological Association Education and Research, Inc.
      Published by Elsevier Inc. All rights reserved.
FAU - Lindner, Uri
AU  - Lindner U
AD  - Surgical Oncology, Urology Division, University Health Network, University of
      Toronto, Toronto, Ontario, Canada.
FAU - Lawrentschuk, Nathan
AU  - Lawrentschuk N
FAU - Weersink, Robert A
AU  - Weersink RA
FAU - Raz, Orit
AU  - Raz O
FAU - Hlasny, Eugen
AU  - Hlasny E
FAU - Sussman, Marshall S
AU  - Sussman MS
FAU - Davidson, Sean R
AU  - Davidson SR
FAU - Gertner, Mark R
AU  - Gertner MR
FAU - Trachtenberg, John
AU  - Trachtenberg J
LA  - eng
PT  - Journal Article
DEP - 20100520
PL  - United States
TA  - J Urol
JT  - The Journal of urology
JID - 0376374
RN  - 0 (Gels)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Equipment Design
MH  - Gadolinium
MH  - Gels
MH  - Humans
MH  - Magnetic Resonance Imaging, Interventional
MH  - Male
MH  - *Models, Anatomic
MH  - *Phantoms, Imaging
MH  - Prostate/pathology/surgery
MH  - Prostatic Neoplasms/pathology/*surgery
MH  - Radiography, Interventional
MH  - Rectum/anatomy & histology
MH  - Ultrasonography, Interventional
MH  - Urethra/anatomy & histology
EDAT- 2010/05/22 06:00
MHDA- 2010/07/29 06:00
CRDT- 2010/05/22 06:00
PHST- 2009/09/15 00:00 [received]
PHST- 2010/05/22 06:00 [entrez]
PHST- 2010/05/22 06:00 [pubmed]
PHST- 2010/07/29 06:00 [medline]
AID - S0022-5347(10)02956-3 [pii]
AID - 10.1016/j.juro.2010.03.001 [doi]
PST - ppublish
SO  - J Urol. 2010 Jul;184(1):352-7. doi: 10.1016/j.juro.2010.03.001. Epub 2010 May 20.


PMID- 20487477
OWN - NLM
STAT- MEDLINE
DCOM- 20100826
LR  - 20100521
IS  - 1466-7657 (Electronic)
IS  - 0020-8132 (Linking)
VI  - 57
IP  - 1
DP  - 2010 Mar
TI  - Culture, context and community: ethical considerations for global nursing
      research.
PG  - 70-7
LID - 10.1111/j.1466-7657.2009.00766.x [doi]
AB  - High-quality research is essential for the generation of scientific nursing
      knowledge and the achievement of the Millennium Development Goals. However, the
      incorporation of Western bioethical principles in the study design may not be
      suitable, sufficient or relevant to participants in low-income countries and may 
      indeed be harmful and disrespectful. Before engaging in global health studies,
      nurses must consider carefully the cultural and social context and values of the 
      proposed setting in order to situate the research within the appropriate ethical 
      framework. The purpose of this paper was to examine the ethical principles and
      considerations that guide health research conducted in international settings
      using the example of a qualitative study of Ugandan nurses and nurse-midwives by 
      a Canadian researcher. The application of Western bioethical principles with
      their emphasis on autonomy fails to acknowledge the importance of relevant
      contextual aspects in the conduct of global research. Because ethics is concerned
      with how people interact and live together, it is essential that studies
      conducted across borders be respectful of, and congruent with, the values and
      needs of the community in which it occurs. The use of a communitarian ethical
      framework will allow nurse scientists to contribute to the elimination of
      inequities between those who enjoy prosperity and good health, and those who do
      not.
FAU - Harrowing, J N
AU  - Harrowing JN
AD  - Faculty of Health Sciences, University of Lethbridge, Lethbridge, Alberta, T1K
      3M4, Canada. harrjn@uleth.ca
FAU - Mill, J
AU  - Mill J
FAU - Spiers, J
AU  - Spiers J
FAU - Kulig, J
AU  - Kulig J
FAU - Kipp, W
AU  - Kipp W
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int Nurs Rev
JT  - International nursing review
JID - 7808754
SB  - IM
MH  - Beneficence
MH  - Canada
MH  - *Cultural Diversity
MH  - Developing Countries
MH  - Humans
MH  - *International Cooperation
MH  - Nursing Research/*ethics
MH  - Uganda/ethnology
MH  - Vulnerable Populations
EDAT- 2010/05/22 06:00
MHDA- 2010/08/27 06:00
CRDT- 2010/05/22 06:00
PHST- 2010/05/22 06:00 [entrez]
PHST- 2010/05/22 06:00 [pubmed]
PHST- 2010/08/27 06:00 [medline]
AID - INR766 [pii]
AID - 10.1111/j.1466-7657.2009.00766.x [doi]
PST - ppublish
SO  - Int Nurs Rev. 2010 Mar;57(1):70-7. doi: 10.1111/j.1466-7657.2009.00766.x.


PMID- 20487405
OWN - NLM
STAT- MEDLINE
DCOM- 20110217
LR  - 20181201
IS  - 1471-6712 (Electronic)
IS  - 0283-9318 (Linking)
VI  - 24
IP  - 4
DP  - 2010 Dec
TI  - Equality as a central concept of nursing ethics: a systematic literature review.
PG  - 824-32
LID - 10.1111/j.1471-6712.2010.00781.x [doi]
AB  - BACKGROUND: Equality is a central concept in the Western way of thinking and in
      health care. In ethics research within nursing science, equality is a key concept
      but the meaning of its contents is more or less presumptive. AIM: The purpose of 
      this study was to define the concept of equality as a value of nursing ethics
      research. METHOD: Data were collected through systematic literature review and
      analysed using deductive and inductive content analysis. FINDINGS: Equality has
      been studied as a concept and in relation to ethical theories. In nursing ethics,
      research on equality on theoretical and functional level is presented. These
      levels consist of dimensions, i.e. themes, that equality is related to. The
      dimensions of the theoretical level are the equality of being, i.e. universal
      human value, and distributive equality, i.e. equal opportunities, circumstances
      and results. The dimensions of functional equality included themes such as
      critique of distributive equality, context, difference, power and care. Critique 
      is aimed at incompatibility of theoretical level with practice. Context raises
      questions of each nursing situation in relation to equality. Variation within
      context is closely related to differences involving parties to nursing, and it is
      a starting point to questions of equality. Power is understood as comprising
      knowledge, skills and authority that create differences and questions of equality
      between nurses and patients and nurses and other professionals or students.
      Nursing as care always includes relationship between two or more persons and
      needs to be inspected from the point of view of equality. CONCLUSION: The concept
      of equality has been complex to achieve in practice. The dimensions of the levels
      of equality defined in this study provide an opportunity to reach a better
      understanding of equality in nursing ethics. There is still a great demand for
      more research on the concept of equality.
CI  - (c) 2010 The Author. Scandinavian Journal of Caring Sciences (c) 2010 Nordic
      College of Caring Science.
FAU - Kangasniemi, Mari
AU  - Kangasniemi M
AD  - Department of Nursing Science, Faculty of Health Sciences, University of Eastern 
      Finland, Kuopio, Finland. mari.kangasniemi@uef.fi
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
PL  - Sweden
TA  - Scand J Caring Sci
JT  - Scandinavian journal of caring sciences
JID - 8804206
MH  - *Ethics, Nursing
MH  - *Social Justice
EDAT- 2010/05/22 06:00
MHDA- 2011/02/18 06:00
CRDT- 2010/05/22 06:00
PHST- 2010/05/22 06:00 [entrez]
PHST- 2010/05/22 06:00 [pubmed]
PHST- 2011/02/18 06:00 [medline]
AID - SCS781 [pii]
AID - 10.1111/j.1471-6712.2010.00781.x [doi]
PST - ppublish
SO  - Scand J Caring Sci. 2010 Dec;24(4):824-32. doi: 10.1111/j.1471-6712.2010.00781.x.


PMID- 20486988
OWN - NLM
STAT- MEDLINE
DCOM- 20100928
LR  - 20100521
IS  - 1365-2354 (Electronic)
IS  - 0961-5423 (Linking)
VI  - 19
IP  - 2
DP  - 2010 Mar
TI  - End of life care.
PG  - 144
LID - 10.1111/j.1365-2354.2010.01179.x [doi]
AB  - This module presents background and encourages personal reflection and learning
      on end of life care terminology, concepts and ethics for all healthcare staff
      working with adult cancer patients. Consideration is given to resuscitation
      issues, communication skills competence and end of life care pathways such as
      Gold Standards Framework and Liverpool Care Pathway for the Dying.
FAU - McGinn, M
AU  - McGinn M
AD  - South West London Cancer Network, Deas Home, Nelson Hospital, Kingston Road,
      London, UK. Maureen.McGinn@smpct.nhs.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur J Cancer Care (Engl)
JT  - European journal of cancer care
JID - 9301979
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Health Personnel/*standards
MH  - Humans
MH  - Middle Aged
MH  - Neoplasms/*therapy
MH  - Palliative Care/ethics/*standards
MH  - Professional-Patient Relations
MH  - Resuscitation
MH  - *Terminally Ill
MH  - *Terminology as Topic
EDAT- 2010/05/22 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/05/22 06:00
PHST- 2010/05/22 06:00 [entrez]
PHST- 2010/05/22 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - ECC1179 [pii]
AID - 10.1111/j.1365-2354.2010.01179.x [doi]
PST - ppublish
SO  - Eur J Cancer Care (Engl). 2010 Mar;19(2):144. doi:
      10.1111/j.1365-2354.2010.01179.x.


PMID- 20486177
OWN - NLM
STAT- MEDLINE
DCOM- 20100624
LR  - 20220318
IS  - 1545-5017 (Electronic)
IS  - 1545-5009 (Linking)
VI  - 55
IP  - 1
DP  - 2010 Jul 15
TI  - Pediatric oncologists' attitudes towards involving adolescents in decision-making
      concerning research participation.
PG  - 123-8
LID - 10.1002/pbc.22510 [doi]
AB  - BACKGROUND: Various regulations and guidelines stipulate the importance of
      involving adolescents in decision-making concerning research participation.
      Several studies have shown that in the context of pediatric oncology this
      involvement is difficult to achieve due to emotional stress, the complexity of
      research protocols and limited time. Still, up to 80% of adolescents with cancer 
      enter onto a trial during their illness. The aim of this study was to determine
      clinicians' views and attitudes towards enrolling adolescents in research,
      considering the difficulties surrounding their involvement in decision-making.
      METHODS: A qualitative multicenter study was performed, using in-depth
      semi-structured interviews on the informed consent process with 15 pediatric
      hemato-oncologists. RESULTS: Four central themes emerged that characterize
      clinicians' attitudes towards involving adolescents in the decision-making
      process: (1) clinicians regard most adolescents as not capable of participating
      meaningfully in discussions regarding research; (2) clinicians do not always
      provide adolescents with all information; (3) proxy consent from parents is
      obtained and is deemed sufficient; (4) clinician-investigator integrity:
      clinicians judge research protocols as not being harmful and even in the best
      interest of the adolescent. CONCLUSIONS: Clinicians justify not involving
      adolescents in research discussions by referring to best interest arguments
      (adolescents' incompetence, proxy consent, and investigator integrity), although 
      this is not in line with legal regulations and ethical guidelines.
FAU - de Vries, Martine C
AU  - de Vries MC
AD  - Department of Medical Humanities (Metamedica), VU University Medical Center,
      Amsterdam, the Netherlands. m.c.de vries@lumc.nl
FAU - Wit, Jan M
AU  - Wit JM
FAU - Engberts, Dirk P
AU  - Engberts DP
FAU - Kaspers, Gertjan J L
AU  - Kaspers GJ
FAU - van Leeuwen, Evert
AU  - van Leeuwen E
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - United States
TA  - Pediatr Blood Cancer
JT  - Pediatric blood & cancer
JID - 101186624
SB  - IM
CIN - Pediatr Blood Cancer. 2010 Jul 15;55(1):8-9. PMID: 20486164
MH  - Adolescent
MH  - *Attitude to Health
MH  - Clinical Trials as Topic
MH  - *Decision Making
MH  - Humans
MH  - Informed Consent
MH  - Neoplasms/diagnosis/drug therapy/*psychology
MH  - *Patient Participation
MH  - Physician-Patient Relations
MH  - Practice Guidelines as Topic
MH  - *Practice Patterns, Physicians'
MH  - *Research
EDAT- 2010/05/21 06:00
MHDA- 2010/06/25 06:00
CRDT- 2010/05/21 06:00
PHST- 2010/05/21 06:00 [entrez]
PHST- 2010/05/21 06:00 [pubmed]
PHST- 2010/06/25 06:00 [medline]
AID - 10.1002/pbc.22510 [doi]
PST - ppublish
SO  - Pediatr Blood Cancer. 2010 Jul 15;55(1):123-8. doi: 10.1002/pbc.22510.


PMID- 20485997
OWN - NLM
STAT- MEDLINE
DCOM- 20110121
LR  - 20220316
IS  - 1651-2316 (Electronic)
IS  - 1650-6073 (Linking)
VI  - 39
IP  - 3
DP  - 2010
TI  - Ethical and legal considerations for internet-based psychotherapy.
PG  - 173-87
LID - 10.1080/16506071003636046 [doi]
AB  - The provision of mental health services over the Internet is becoming
      increasingly commonplace as new technologies continue to develop. Evidence in
      support of the efficacy of many such interventions is accumulating. Given the
      potential global reach of Internet-based psychological services, the authors
      examine ethical issues relating to this growing area of practice through the lens
      of the Universal Declaration of Ethical Principles for Psychologists
      (International Union of Psychological Science, 2008). They also raise issues
      relating to potential liability risks and offer recommendations intended to guide
      mental health practitioners who are considering involvement in the provision of
      Internet-based services.
FAU - Dever Fitzgerald, Theresa
AU  - Dever Fitzgerald T
AD  - Department of Psychology, University of Regina, Regina, Saskatchewan, Canada.
FAU - Hunter, Paulette V
AU  - Hunter PV
FAU - Hadjistavropoulos, Thomas
AU  - Hadjistavropoulos T
FAU - Koocher, Gerald P
AU  - Koocher GP
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Cogn Behav Ther
JT  - Cognitive behaviour therapy
JID - 101143317
SB  - IM
MH  - Humans
MH  - International Cooperation
MH  - Internet/ethics/legislation & jurisprudence/*statistics & numerical data
MH  - Mental Health Services/*ethics/*legislation & jurisprudence
MH  - Practice Guidelines as Topic
MH  - Psychotherapy/*ethics/*legislation & jurisprudence
EDAT- 2010/05/21 06:00
MHDA- 2011/01/22 06:00
CRDT- 2010/05/21 06:00
PHST- 2010/05/21 06:00 [entrez]
PHST- 2010/05/21 06:00 [pubmed]
PHST- 2011/01/22 06:00 [medline]
AID - 922362835 [pii]
AID - 10.1080/16506071003636046 [doi]
PST - ppublish
SO  - Cogn Behav Ther. 2010;39(3):173-87. doi: 10.1080/16506071003636046.


PMID- 20485361
OWN - NLM
STAT- MEDLINE
DCOM- 20101215
LR  - 20100830
IS  - 1476-5543 (Electronic)
IS  - 0743-8346 (Linking)
VI  - 30
IP  - 9
DP  - 2010 Sep
TI  - Effectiveness of epidural anesthesia for external cephalic version (ECV).
PG  - 580-3
LID - 10.1038/jp.2010.61 [doi]
AB  - OBJECTIVE: The Cochrane review conducted in 2001 re-established the usefulness of
      external cephalic version (ECV). The success rate for ECV using epidural
      anesthesia or spinal anesthesia is reported to be 35 to 86%. In this study, we
      examined the effectiveness of epidural anesthesia for ECV. STUDY DESIGN: A
      retrospective cohort study was conducted of pregnant women who were at 35 to 36
      weeks of gestation between 2001 and June 2009, with a single fetus, non-cephalic 
      presentation and without non-reassuring fetal status. The subjects were
      ultrasonographically examined for placental location, presence/absence of nuchal 
      cord and amniotic fluid volume. Those with placenta previa, early rupture of
      membranes, uterine anomaly or severe fetal anomaly and those in whom delivery was
      initiated were excluded from the study. The study protocol was approved by the
      institutional ethics committee, and written informed consent was obtained for all
      procedures described in the protocol. The success rate for ECV was compared
      between the anesthesia and non-anesthesia groups. Analysis was also performed to 
      identify factors contributing to successful ECV. RESULT: There were 86 women with
      non-cephalic presentation who underwent ECV during the study period. The
      non-anesthesia group consisted of 34 women in whom ritodrine hydrochloride, a
      tocolytic agent, was administered alone, and 52 women in whom a tocolytic agent
      and epidural anesthesia were used constituted the anesthesia group. There were no
      significant differences between the two groups in terms of age, parity, body mass
      index and placental location. The success rate for ECV was 55.9% (19/34 patients)
      in the non-anesthesia group and 78.8% (41/52 patients) in the anesthesia group,
      showing a significant difference between the two groups (odds ratio 1.75, 95%
      confidence interval 1.26 to 2.44). Analysis was also performed to identify
      factors determining successful ECV other than epidural anesthesia from among age,
      parity, body mass index, placental location, presence/absence of uterine myoma,
      nuchal code and previous cesarean delivery; however, none of the factors
      identified was found to be a significant determinant factor. CONCLUSION: The use 
      of epidural anesthesia significantly increases the success rate for ECV for
      breech presentation.
FAU - Yoshida, M
AU  - Yoshida M
AD  - Department of Obstetrics and Gynecology, National Defense Medical College,
      Saitama, Japan. dr22023@ndmc.ac.jp
FAU - Matsuda, H
AU  - Matsuda H
FAU - Kawakami, Y
AU  - Kawakami Y
FAU - Hasegawa, Y
AU  - Hasegawa Y
FAU - Yoshinaga, Y
AU  - Yoshinaga Y
FAU - Hayata, E
AU  - Hayata E
FAU - Asai, K
AU  - Asai K
FAU - Kawashima, A
AU  - Kawashima A
FAU - Furuya, K
AU  - Furuya K
LA  - eng
PT  - Journal Article
DEP - 20100520
PL  - United States
TA  - J Perinatol
JT  - Journal of perinatology : official journal of the California Perinatal
      Association
JID - 8501884
SB  - IM
CIN - J Perinatol. 2010 Sep;30(9):569-70. PMID: 20802508
MH  - Adult
MH  - *Anesthesia, Epidural
MH  - Anesthesia, Obstetrical
MH  - Breech Presentation/*therapy
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Pregnancy
MH  - Retrospective Studies
MH  - Version, Fetal/*methods
MH  - Young Adult
EDAT- 2010/05/21 06:00
MHDA- 2010/12/16 06:00
CRDT- 2010/05/21 06:00
PHST- 2010/05/21 06:00 [entrez]
PHST- 2010/05/21 06:00 [pubmed]
PHST- 2010/12/16 06:00 [medline]
AID - jp201061 [pii]
AID - 10.1038/jp.2010.61 [doi]
PST - ppublish
SO  - J Perinatol. 2010 Sep;30(9):580-3. doi: 10.1038/jp.2010.61. Epub 2010 May 20.


PMID- 20484382
OWN - NLM
STAT- MEDLINE
DCOM- 20101028
LR  - 20211020
IS  - 1096-0929 (Electronic)
IS  - 1096-0929 (Linking)
VI  - 116
IP  - 2
DP  - 2010 Aug
TI  - Cross-sector review of drivers and available 3Rs approaches for acute systemic
      toxicity testing.
PG  - 382-96
LID - 10.1093/toxsci/kfq143 [doi]
AB  - Acute systemic toxicity studies are carried out in many sectors in which
      synthetic chemicals are manufactured or used and are among the most criticized of
      all toxicology tests on both scientific and ethical grounds. A review of the
      drivers for acute toxicity testing within the pharmaceutical industry led to a
      paradigm shift whereby in vivo acute toxicity data are no longer routinely
      required in advance of human clinical trials. Based on this experience, the
      following review was undertaken to identify (1) regulatory and scientific drivers
      for acute toxicity testing in other industrial sectors, (2) activities aimed at
      replacing, reducing, or refining the use of animals, and (3) recommendations for 
      future work in this area.
FAU - Seidle, Troy
AU  - Seidle T
AD  - Research & Toxicology Department, Humane Society International, B-1030 Brussels, 
      Belgium. tseidle@hsi.org
FAU - Robinson, Sally
AU  - Robinson S
FAU - Holmes, Tom
AU  - Holmes T
FAU - Creton, Stuart
AU  - Creton S
FAU - Prieto, Pilar
AU  - Prieto P
FAU - Scheel, Julia
AU  - Scheel J
FAU - Chlebus, Magda
AU  - Chlebus M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100519
PL  - United States
TA  - Toxicol Sci
JT  - Toxicological sciences : an official journal of the Society of Toxicology
JID - 9805461
SB  - IM
MH  - Animal Testing Alternatives
MH  - Animals
MH  - Endpoint Determination
MH  - Guidelines as Topic
MH  - Humans
MH  - Lethal Dose 50
MH  - Toxicity Tests, Acute/*methods
PMC - PMC2905404
EDAT- 2010/05/21 06:00
MHDA- 2010/10/29 06:00
CRDT- 2010/05/21 06:00
PHST- 2010/05/21 06:00 [entrez]
PHST- 2010/05/21 06:00 [pubmed]
PHST- 2010/10/29 06:00 [medline]
AID - kfq143 [pii]
AID - 10.1093/toxsci/kfq143 [doi]
PST - ppublish
SO  - Toxicol Sci. 2010 Aug;116(2):382-96. doi: 10.1093/toxsci/kfq143. Epub 2010 May
      19.


PMID- 20483851
OWN - NLM
STAT- MEDLINE
DCOM- 20100930
LR  - 20220309
IS  - 1467-9280 (Electronic)
IS  - 0956-7976 (Linking)
VI  - 21
IP  - 5
DP  - 2010 May
TI  - The counterfeit self: the deceptive costs of faking it.
PG  - 712-20
LID - 10.1177/0956797610366545 [doi]
AB  - Although people buy counterfeit products to signal positive traits, we show that 
      wearing counterfeit products makes individuals feel less authentic and increases 
      their likelihood of both behaving dishonestly and judging others as unethical. In
      four experiments, participants wore purportedly fake or authentically branded
      sunglasses. Those wearing fake sunglasses cheated more across multiple tasks than
      did participants wearing authentic sunglasses, both when they believed they had a
      preference for counterfeits (Experiment 1a) and when they were randomly assigned 
      to wear them (Experiment 1b). Experiment 2 shows that the effects of wearing
      counterfeit sunglasses extend beyond the self, influencing judgments of other
      people's unethical behavior. Experiment 3 demonstrates that the feelings of
      inauthenticity that wearing fake products engenders-what we term the counterfeit 
      self-mediate the impact of counterfeits on unethical behavior. Finally, we show
      that people do not predict the impact of counterfeits on ethicality; thus, the
      costs of counterfeits are deceptive.
FAU - Gino, Francesca
AU  - Gino F
AD  - University of North Carolina-Chapel Hill, Kenan-Flagler Business School, Campus
      Box 3490, McColl Building, Chapel Hill, NC 27599-3490, USA. fgino@unc.edu
FAU - Norton, Michael I
AU  - Norton MI
FAU - Ariely, Dan
AU  - Ariely D
LA  - eng
PT  - Journal Article
DEP - 20100323
PL  - United States
TA  - Psychol Sci
JT  - Psychological science
JID - 9007542
SB  - IM
MH  - Awareness
MH  - Choice Behavior
MH  - *Deception
MH  - Decision Making
MH  - Female
MH  - Humans
MH  - *Interpersonal Relations
MH  - *Morals
MH  - Orientation
MH  - Pattern Recognition, Visual
MH  - Problem Solving
MH  - *Self Concept
MH  - *Social Behavior
MH  - *Social Desirability
MH  - Suggestion
MH  - Young Adult
EDAT- 2010/05/21 06:00
MHDA- 2010/10/01 06:00
CRDT- 2010/05/21 06:00
PHST- 2010/05/21 06:00 [entrez]
PHST- 2010/05/21 06:00 [pubmed]
PHST- 2010/10/01 06:00 [medline]
AID - 0956797610366545 [pii]
AID - 10.1177/0956797610366545 [doi]
PST - ppublish
SO  - Psychol Sci. 2010 May;21(5):712-20. doi: 10.1177/0956797610366545. Epub 2010 Mar 
      23.


PMID- 20482820
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1472-698X (Electronic)
IS  - 1472-698X (Linking)
VI  - 10
DP  - 2010 May 19
TI  - Human-animal chimeras for vaccine development: an endangered species or
      opportunity for the developing world?
PG  - 8
LID - 10.1186/1472-698X-10-8 [doi]
AB  - BACKGROUND: In recent years, the field of vaccines for diseases such as Human
      Immunodeficiency Virus (HIV) which take a heavy toll in developing countries has 
      faced major failures. This has led to a call for more basic science research, and
      development as well as evaluation of new vaccine candidates. Human-animal
      chimeras, developed with a 'humanized' immune system could be useful to study
      infectious diseases, including many neglected diseases. These would also serve as
      an important tool for the efficient testing of new vaccine candidates to
      streamline promising candidates for further trials in humans. However, developing
      human-animal chimeras has proved to be controversial. DISCUSSION: Development of 
      human-animal chimeras for vaccine development has been slowed down because of
      opposition by some philosophers, ethicists and policy makers in the west-they
      question the moral status of such animals, and also express discomfort about
      transgression of species barriers. Such opposition often uses a contemporary
      western world view as a reference point. Human-animal chimeras are often being
      created for diseases which cause significantly higher morbidity and mortality in 
      the developing world as compared to the developed world. We argue in our
      commentary that given this high disease burden, we should look at socio-cultural 
      perspectives on human-animal chimera like beings in the developing world. On
      examination, it's clear that such beings have been part of mythology and cultural
      descriptions in many countries in the developing world. SUMMARY: To ensure that
      important research on diseases afflicting millions like malaria, HIV, Hepatitis-C
      and dengue continues to progress, we recommend supporting human-animal chimera
      research for vaccine development in developing countries (especially China and
      India which have growing technical expertise in the area). The negative
      perceptions in some parts of the west about human-animal chimeras can be used as 
      an opportunity for nurturing important vaccine development research in the
      developing world.
FAU - Bhan, Anant
AU  - Bhan A
AD  - McLaughlin-Rotman Centre for Global Health, University Health Network and
      University of Toronto, Toronto, Canada and Dalla Lana School of Public Health,
      University of Toronto, Toronto, Ontario, Canada. a.daar@utoronto.ca.
FAU - Singer, Peter A
AU  - Singer PA
FAU - Daar, Abdallah S
AU  - Daar AS
LA  - eng
PT  - Journal Article
DEP - 20100519
PL  - England
TA  - BMC Int Health Hum Rights
JT  - BMC international health and human rights
JID - 101088678
PMC - PMC2890684
EDAT- 2010/05/21 06:00
MHDA- 2010/05/21 06:01
CRDT- 2010/05/21 06:00
PHST- 2009/10/28 00:00 [received]
PHST- 2010/05/19 00:00 [accepted]
PHST- 2010/05/21 06:00 [entrez]
PHST- 2010/05/21 06:00 [pubmed]
PHST- 2010/05/21 06:01 [medline]
AID - 1472-698X-10-8 [pii]
AID - 10.1186/1472-698X-10-8 [doi]
PST - epublish
SO  - BMC Int Health Hum Rights. 2010 May 19;10:8. doi: 10.1186/1472-698X-10-8.


PMID- 20481403
OWN - NLM
STAT- MEDLINE
DCOM- 20100616
LR  - 20191111
IS  - 0098-8588 (Print)
IS  - 0098-8588 (Linking)
VI  - 36
IP  - 1
DP  - 2010
TI  - Towards a new moral paradigm in health care delivery: accounting for individuals.
PG  - 78-135
AB  - For years, commentators have debated how to most appropriately allocate scarce
      medical resources over large populations. In this paper, I abstract the major
      rationing schema into three general approaches: rationing by price, quantity, and
      prioritization. Each has both normative appeal and considerable weakness. After
      exploring them, I present what some commentators have termed the "moral paradigm"
      as an alternative to broader philosophies designed to encapsulate the universe of
      options available to allocators (often termed the market, professional, and
      political paradigms). While not itself an abstraction of any specific viable
      rationing scheme, it provides a strong basis for the development of a new scheme 
      that offers considerable moral and political appeal often absent from
      traditionally employed rationing schema. As I explain, the moral paradigm, in its
      strong, absolute, and uncompromising version, is economically untenable. This
      paper articulates a modified version of the moral paradigm that is pluralist in
      nature rather than absolute. It appeals to the moral, emotional, and irrational
      sensibilities of each individual person. The moral paradigm, so articulated, can 
      complement any health care delivery system that policy-makers adopt. It functions
      by granting individuals the ability to appeal to an administrative adjudicatory
      board designated for this purpose. The adjudicatory board would have the
      expertise and power to act in response to the complaints of individual aggrieved 
      patients, including those complaints that stem from the moral, religious,
      ethical, emotional, irrational, or other subjective positions of the patient, and
      would have plenary power to affirm the denial of access to medical care or to
      mandate the provision of such care. The board must be designed to facilitate its 
      intended function while creating structural limitations on abuse of power and
      other excess. I make some specific suggestions on matters of structure and
      function in the hope of demonstrating both that this adjudicatory model can
      function and that it can do so immediately, regardless of the underlying health
      care delivery system or its theoretical underpinnings.
FAU - Katz, Meir
AU  - Katz M
AD  - Georgetown University Law Center, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Am J Law Med
JT  - American journal of law & medicine
JID - 7509572
SB  - IM
MH  - *Advisory Committees
MH  - Health Care Rationing/*ethics
MH  - *Health Services Accessibility
MH  - Humans
MH  - *Morals
MH  - *Social Justice
MH  - United States
EDAT- 2010/05/21 06:00
MHDA- 2010/06/17 06:00
CRDT- 2010/05/21 06:00
PHST- 2010/05/21 06:00 [entrez]
PHST- 2010/05/21 06:00 [pubmed]
PHST- 2010/06/17 06:00 [medline]
AID - 10.1177/009885881003600102 [doi]
PST - ppublish
SO  - Am J Law Med. 2010;36(1):78-135. doi: 10.1177/009885881003600102.


PMID- 20481069
OWN - NLM
STAT- MEDLINE
DCOM- 20100607
LR  - 20100520
IS  - 0002-7979 (Print)
IS  - 0002-7979 (Linking)
VI  - 77
IP  - 1
DP  - 2010 Winter
TI  - Evil games.
PG  - 35-43
AB  - A defining characteristic of humans is our capacity to create a better world
      through mutual action. Traditional ethics attempts to define and impose the one
      or several things we should all want. The alternative argued here is that we can 
      retain our individual definitions of what matters and still work together for
      mutual improvement. Agreeing on common ethical principles is not a precondition
      for an effective moral life. This approach to morality is based on game theory,
      which holds that in purposely social interactions: (a) there are basic
      understandings, (b) individuals pursue their own interests, (c) we can judge
      others' interests, and (d) the distribution of benefits and burdens depends on
      the joint action of individuals, not on the action of individuals in isolation.
      In this view, immorality becomes a matter of cheating in the game of life. The
      three primary forms of cheating are deception (misleading others into thinking
      they are playing a game other than the one that is to their advantage to play),
      coercion (blocking courses of action others would normally be entitled to), and
      reneging (playing the game and then dodging the payoff if one does not like the
      outcome). These three evils are illustrated by Shakespeare's plays Othello,
      Richard III, and Antony and Cleopatra.
FAU - Chambers, David W
AU  - Chambers DW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Coll Dent
JT  - The Journal of the American College of Dentists
JID - 7503057
SB  - IM
MH  - Coercion
MH  - Deception
MH  - *Ethical Theory
MH  - *Game Theory
MH  - Humans
MH  - *Interpersonal Relations
MH  - Moral Development
MH  - Personal Autonomy
EDAT- 2010/05/21 06:00
MHDA- 2010/06/09 06:00
CRDT- 2010/05/21 06:00
PHST- 2010/05/21 06:00 [entrez]
PHST- 2010/05/21 06:00 [pubmed]
PHST- 2010/06/09 06:00 [medline]
PST - ppublish
SO  - J Am Coll Dent. 2010 Winter;77(1):35-43.


PMID- 20481068
OWN - NLM
STAT- MEDLINE
DCOM- 20100607
LR  - 20131121
IS  - 0002-7979 (Print)
IS  - 0002-7979 (Linking)
VI  - 77
IP  - 1
DP  - 2010 Winter
TI  - The dental patient who is "high:" ethical and scientific recommendations for the 
      standard of care.
PG  - 21-34
AB  - Patients sometimes appear for dental appointments after consuming alcohol or
      marijuana. There is presently no consensus standard of care in this area, and
      dentists vary in their responses to such patients. This paper includes interviews
      with practitioners and a review of the relevant biochemical and physiological
      science. The ethics of various ways to handle this challenging situation are
      examined, and evidence-based recommendations for dental practice are offered.
      While there is reason for caution, the authors conclude that a blanket "do not
      treat" policy is unwarranted. Informed consent and transportation safety issues
      pose significant moral challenges when a dental patient is "high."
FAU - Peltier, Bruce
AU  - Peltier B
AD  - University of the Pacific, Arthur A. Dugoni School of Dentistry, San Francisco,
      USA. bpeltier@pacific.edu
FAU - Giusti, Lola
AU  - Giusti L
FAU - Hoover, Terry
AU  - Hoover T
FAU - Fountain, Jennifer
AU  - Fountain J
FAU - Persinger, Jared
AU  - Persinger J
FAU - Sutter, Scott
AU  - Sutter S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Coll Dent
JT  - The Journal of the American College of Dentists
JID - 7503057
RN  - 0 (Cannabinoids)
RN  - 0 (Pharmaceutical Preparations, Dental)
RN  - 3K9958V90M (Ethanol)
SB  - IM
CIN - J Am Coll Dent. 2010 Fall;77(3):4. PMID: 21314043
MH  - *Alcohol Drinking
MH  - Automobile Driving
MH  - Cannabinoids/metabolism
MH  - Clinical Protocols
MH  - *Dentist-Patient Relations
MH  - Drug Interactions
MH  - Ethanol/metabolism
MH  - Ethics, Dental
MH  - Humans
MH  - Informed Consent
MH  - *Marijuana Smoking
MH  - Pharmaceutical Preparations, Dental/metabolism
MH  - Refusal to Treat
MH  - Vital Signs
EDAT- 2010/05/21 06:00
MHDA- 2010/06/09 06:00
CRDT- 2010/05/21 06:00
PHST- 2010/05/21 06:00 [entrez]
PHST- 2010/05/21 06:00 [pubmed]
PHST- 2010/06/09 06:00 [medline]
PST - ppublish
SO  - J Am Coll Dent. 2010 Winter;77(1):21-34.


PMID- 20481064
OWN - NLM
STAT- MEDLINE
DCOM- 20100607
LR  - 20100520
IS  - 0002-7979 (Print)
IS  - 0002-7979 (Linking)
VI  - 77
IP  - 1
DP  - 2010 Winter
TI  - Following your moral compass: ethics in dental school.
PG  - 4-9
FAU - Meru, Michael
AU  - Meru M
LA  - eng
PT  - Editorial
PL  - United States
TA  - J Am Coll Dent
JT  - The Journal of the American College of Dentists
JID - 7503057
SB  - IM
MH  - Codes of Ethics
MH  - *Deception
MH  - Education, Dental/*ethics
MH  - Educational Measurement
MH  - *Ethics, Dental
MH  - Humans
MH  - Societies, Dental
MH  - *Students, Dental
EDAT- 2010/05/21 06:00
MHDA- 2010/06/09 06:00
CRDT- 2010/05/21 06:00
PHST- 2010/05/21 06:00 [entrez]
PHST- 2010/05/21 06:00 [pubmed]
PHST- 2010/06/09 06:00 [medline]
PST - ppublish
SO  - J Am Coll Dent. 2010 Winter;77(1):4-9.


PMID- 20481038
OWN - NLM
STAT- MEDLINE
DCOM- 20100616
LR  - 20100520
IS  - 1096-6293 (Print)
IS  - 1096-6293 (Linking)
VI  - 18
IP  - 2
DP  - 2010 Feb
TI  - Can versus should. A collision course with ethics.
PG  - 70
FAU - Amazon, Jody
AU  - Amazon J
AD  - Horizons Healthcare, Snellville, Ga., USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Adv Nurse Pract
JT  - Advance for nurse practitioners
JID - 9892010
MH  - Aged
MH  - Alzheimer Disease/*nursing
MH  - Humans
MH  - Male
MH  - Nurse Practitioners/*ethics
MH  - *Patient Advocacy
MH  - Restraint, Physical/*ethics
MH  - United States
EDAT- 2010/05/21 06:00
MHDA- 2010/06/17 06:00
CRDT- 2010/05/21 06:00
PHST- 2010/05/21 06:00 [entrez]
PHST- 2010/05/21 06:00 [pubmed]
PHST- 2010/06/17 06:00 [medline]
PST - ppublish
SO  - Adv Nurse Pract. 2010 Feb;18(2):70.


PMID- 20480571
OWN - NLM
STAT- MEDLINE
DCOM- 20100615
LR  - 20100518
IS  - 0160-7480 (Print)
IS  - 0160-7480 (Linking)
VI  - 40
IP  - 17
DP  - 2010 Apr 26
TI  - Move to fight fraud. Transcription trade groups offer ethics guide.
PG  - 17
FAU - Conn, Joseph
AU  - Conn J
LA  - eng
PT  - News
PL  - United States
TA  - Mod Healthc
JT  - Modern healthcare
JID - 7801798
MH  - Fraud/*prevention & control
MH  - *Guidelines as Topic
MH  - *Medical Records
MH  - United States
EDAT- 2010/05/19 06:00
MHDA- 2010/06/16 06:00
CRDT- 2010/05/19 06:00
PHST- 2010/05/19 06:00 [entrez]
PHST- 2010/05/19 06:00 [pubmed]
PHST- 2010/06/16 06:00 [medline]
PST - ppublish
SO  - Mod Healthc. 2010 Apr 26;40(17):17.


PMID- 20480209
OWN - NLM
STAT- MEDLINE
DCOM- 20101210
LR  - 20220408
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 22
IP  - 2
DP  - 2010 Jun
TI  - The National Consensus Project for Quality Palliative Care Clinical Practice
      Guidelines Domain 8: ethical and legal aspects of care.
PG  - 117-31
LID - 10.1007/s10730-010-9128-3 [doi]
AB  - In 2001, leaders with palliative care convened to discuss the standardization of 
      palliative care and formed the National Consensus Project for Quality Palliative 
      Care. In 2004, the National Consensus Project for Quality Palliative Care
      produced the first edition of Clinical Guidelines for Quality Palliative Care.
      The Guidelines were developed by leaders in the field who examined other national
      and international standards with the intent to promote consistent, accessible,
      comprehensive, optimal palliative care through the health care spectrum. Within
      the guidelines there are eight domains to the provision of palliative care. This 
      article focuses on the last, but very significant Domain 8--Ethical and Legal
      Aspects of Care.
FAU - Colby, William H
AU  - Colby WH
AD  - Truman Medical Center, Kansas City, MO, USA. NBeltramo@practicalbioethics.org
FAU - Dahlin, Constance
AU  - Dahlin C
FAU - Lantos, John
AU  - Lantos J
FAU - Carney, John
AU  - Carney J
FAU - Christopher, Myra
AU  - Christopher M
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - Adolescent
MH  - Advance Care Planning/ethics/legislation & jurisprudence
MH  - Child
MH  - Electric Countershock/history
MH  - Ethics Committees, Clinical
MH  - History, 20th Century
MH  - Humans
MH  - Life Support Care/ethics/legislation & jurisprudence
MH  - Minors
MH  - Palliative Care/*ethics/*legislation & jurisprudence
MH  - *Practice Guidelines as Topic
MH  - *Quality of Health Care
MH  - United States
EDAT- 2010/05/19 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/05/19 06:00
PHST- 2010/05/19 06:00 [entrez]
PHST- 2010/05/19 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1007/s10730-010-9128-3 [doi]
PST - ppublish
SO  - HEC Forum. 2010 Jun;22(2):117-31. doi: 10.1007/s10730-010-9128-3.


PMID- 20480208
OWN - NLM
STAT- MEDLINE
DCOM- 20101210
LR  - 20211020
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 22
IP  - 2
DP  - 2010 Jun
TI  - Medical error, malpractice and complications: a moral geography.
PG  - 145-57
LID - 10.1007/s10730-010-9130-9 [doi]
AB  - This essay reviews and defines avoidable medical error, malpractice and
      complication. The relevant ethical principles pertaining to unanticipated medical
      outcomes are identified. In light of these principles I critically review the
      moral culpability of the agents in each circumstance and the resulting
      obligations to patients, their families, and the health care system in general.
      While I touch on some legal implications, a full discussion of legal obligations 
      and liability issues is beyond the scope of this paper.
FAU - Zientek, David M
AU  - Zientek DM
AD  - Seton Medical Center, Austin, TX, USA. d.zientekmd@gmail.com
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - Humans
MH  - *Malpractice
MH  - *Medical Errors
MH  - *Moral Obligations
MH  - Professional-Patient Relations/*ethics
MH  - Terminology as Topic
EDAT- 2010/05/19 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/05/19 06:00
PHST- 2010/05/19 06:00 [entrez]
PHST- 2010/05/19 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1007/s10730-010-9130-9 [doi]
PST - ppublish
SO  - HEC Forum. 2010 Jun;22(2):145-57. doi: 10.1007/s10730-010-9130-9.


PMID- 20479696
OWN - NLM
STAT- MEDLINE
DCOM- 20110304
LR  - 20220318
IS  - 1537-4505 (Electronic)
IS  - 1531-7129 (Linking)
VI  - 31
IP  - 9
DP  - 2010 Dec
TI  - Systematic review of middle ear implants: do they improve hearing as much as
      conventional hearing AIDS?
PG  - 1369-75
LID - 10.1097/MAO.0b013e3181db716c [doi]
AB  - OBJECTIVE: A systematic review to determine whether middle ear implants (MEIs)
      improve hearing as much as hearing aids. DATA SOURCES: Databases included
      MEDLINE, EMBASE, DARE, and Cochrane searched with no language restrictions from
      1950 or the start date of each database. STUDY SELECTION: Initial search found
      644 articles, of which 17 met the inclusion criteria of MEI in adults with a
      sensorineural hearing loss, where hearing outcomes and patient-reported outcome
      measures (PROMs) compared MEI with conventional hearing aids (CHAs). DATA
      EXTRACTION: Study quality assessment included whether ethical approval was
      gained, the study was prospective, eligibility criteria specified, a power
      calculation made and appropriate controls, outcome measures, and analysis
      performed. Middle ear implant outcome analysis included residual hearing,
      complications, and comparison to CHA in terms of functional gain, speech
      perception in quiet and in noise, and validated PROM questionnaires. DATA
      SYNTHESIS: Because of heterogeneity of outcome measures, comparisons were made by
      structured review. CONCLUSION: The quality of studies was moderate to poor with
      short follow-up. The evidence supports the use of MEI because, overall, they do
      not decrease residual hearing, result in a functional gain in hearing comparable 
      to CHA, and may improve perception of speech in noise and sound quality. We
      recommend the publication of long-term results comparing MEI with CHA, reporting 
      a minimum of functional gain, speech perception in quiet and in noise,
      complications, and a validated PROM to guide the engineering of the new
      generation of MEI in the future.
FAU - Tysome, James R
AU  - Tysome JR
AD  - Department of Otolaryngology-Head and Neck Surgery, St. Thomas' Hospital, London,
      UK. jamestysome@yahoo.com
FAU - Moorthy, Ram
AU  - Moorthy R
FAU - Lee, Ambrose
AU  - Lee A
FAU - Jiang, Dan
AU  - Jiang D
FAU - O'Connor, Alec Fitzgerald
AU  - O'Connor AF
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
PL  - United States
TA  - Otol Neurotol
JT  - Otology & neurotology : official publication of the American Otological Society, 
      American Neurotology Society [and] European Academy of Otology and Neurotology
JID - 100961504
SB  - IM
MH  - Audiology
MH  - Data Interpretation, Statistical
MH  - Hearing
MH  - *Hearing Aids
MH  - Hearing Disorders/*surgery/*therapy
MH  - Hearing Loss, Sensorineural/therapy
MH  - Humans
MH  - *Ossicular Prosthesis
MH  - Patient Satisfaction
MH  - Randomized Controlled Trials as Topic
MH  - Research Design
MH  - Speech Perception
MH  - Transducers
MH  - Treatment Outcome
EDAT- 2010/05/19 06:00
MHDA- 2011/03/05 06:00
CRDT- 2010/05/19 06:00
PHST- 2010/05/19 06:00 [entrez]
PHST- 2010/05/19 06:00 [pubmed]
PHST- 2011/03/05 06:00 [medline]
AID - 10.1097/MAO.0b013e3181db716c [doi]
PST - ppublish
SO  - Otol Neurotol. 2010 Dec;31(9):1369-75. doi: 10.1097/MAO.0b013e3181db716c.


PMID- 20479448
OWN - NLM
STAT- MEDLINE
DCOM- 20101012
LR  - 20191027
IS  - 1930-8264 (Electronic)
IS  - 1930-8264 (Linking)
VI  - 100
IP  - 3
DP  - 2010 May-Jun
TI  - Strength of braided polyblend polyethylene sutures versus braided polyester
      sutures in Achilles tendon repair: a cadaveric study.
PG  - 185-8
AB  - BACKGROUND: Various techniques may be used to repair Achilles tendon ruptures;
      however, we contend that using the strongest suture with the least amount of
      suture material is ideal. METHODS: To compare the strength of 2-0 FiberLoop
      (Arthrex Inc, Naples, Florida) and #2 Ethibond (Ethicon Inc, Somerville, New
      Jersey) suture materials in Achilles tendon repairs, 12 Achilles tendons were
      harvested from cadavers aged 18 to 62 years (median age, 42 years). The tendons
      were transected and repaired using a modified Krackow suture technique. All of
      the right limbs were repaired with 2-0 FiberLoop, and the contralateral side was 
      repaired with #2 Ethibond. The specimens were mounted to a materials testing
      system, and the repairs were pulled to failure in an anatomical direction.
      RESULTS: The mean +/- SD yield loads of 2-0 FiberLoop and #2 Ethibond were 233
      +/- 48 N and 134 +/- 34 N, respectively (P = .002). The mean +/- SD ultimate load
      of 2-0 FiberLoop was 282 +/- 58 N, and that of #2 Ethibond was 135 +/- 33 N (P < 
      .001). The cross-sectional area of one pass of 2-0 FiberLoop was calculated to be
      0.21 mm(2), and one pass of #2 Ethibond was 0.28 mm(2). CONCLUSIONS: The
      smaller-caliber 2-0 FiberLoop was significantly stronger than #2 Ethibond. This
      study suggests that there is no advantage to using the traditional larger suture 
      material for Achilles tendon repairs; however, further clinical testing is needed
      to determine the optimal repair technique.
FAU - Cook, Keith D
AU  - Cook KD
AD  - Podiatric Medical Education, University Hospital-University of Medicine and
      Dentistry of New Jersey, Newark, NJ 07101, USA. cookkd@umdnj.edu
FAU - Clark, Greg
AU  - Clark G
FAU - Lui, Eric
AU  - Lui E
FAU - Vajaria, Gaurav
AU  - Vajaria G
FAU - Wallace, George F
AU  - Wallace GF
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Podiatr Med Assoc
JT  - Journal of the American Podiatric Medical Association
JID - 8501423
RN  - 0 (Polyesters)
RN  - 9002-88-4 (Polyethylene)
SB  - IM
MH  - Achilles Tendon/*injuries/physiopathology/surgery
MH  - Adolescent
MH  - Adult
MH  - Ankle Injuries/physiopathology/*surgery
MH  - Biomechanical Phenomena
MH  - Cadaver
MH  - Equipment Design
MH  - Humans
MH  - Middle Aged
MH  - Orthopedic Procedures/*methods
MH  - *Polyesters
MH  - *Polyethylene
MH  - Rupture
MH  - Suture Techniques/*instrumentation
MH  - *Sutures
MH  - Young Adult
EDAT- 2010/05/19 06:00
MHDA- 2010/10/13 06:00
CRDT- 2010/05/19 06:00
PHST- 2010/05/19 06:00 [entrez]
PHST- 2010/05/19 06:00 [pubmed]
PHST- 2010/10/13 06:00 [medline]
AID - 100/3/185 [pii]
AID - 10.7547/1000185 [doi]
PST - ppublish
SO  - J Am Podiatr Med Assoc. 2010 May-Jun;100(3):185-8. doi: 10.7547/1000185.


PMID- 20478647
OWN - NLM
STAT- MEDLINE
DCOM- 20111123
LR  - 20220316
IS  - 1532-3099 (Electronic)
IS  - 0266-6138 (Linking)
VI  - 27
IP  - 4
DP  - 2011 Aug
TI  - The good midwife: commencing students' views.
PG  - 503-8
LID - 10.1016/j.midw.2010.03.012 [doi]
AB  - OBJECTIVE: to explore commencing students' views of the good midwife. This study 
      was set against a background of high course attrition and concerns that
      discordant students' views of midwifery practice may have been associated with
      course attrition. DESIGN: qualitative thematic analysis. SETTING: Melbourne,
      Australia. PARTICIPANTS: all commencing midwifery students, in 2008, were invited
      to participate (n = 41). MEASUREMENTS AND FINDINGS: students spoke of a series of
      key attributes they felt were important to the role of the midwife. Most fell
      into the affective domain and four themes were identified: personal qualities and
      attitudes; a belief in women and natural birth; compatible work ethic; and the
      possession of additional attributes. KEY CONCLUSIONS AND IMPLICATIONS FOR
      PRACTICE: commencing students showed a clear understanding of the affective
      attributes required of a good midwife but a lesser understanding of requirements 
      of knowledge and competence. A small number of students felt that they were
      already equipped to advise pregnant women, despite their early stage in the
      course. This is an issue that needs to be addressed.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Carolan, Mary
AU  - Carolan M
AD  - Department of Nursing and Midwifery, University of Limerick, Health Sciences
      Building, North Bank Campus, Ireland. mary.carolan@UL.ie
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100515
PL  - Scotland
TA  - Midwifery
JT  - Midwifery
JID - 8510930
MH  - Adult
MH  - Education, Nursing, Baccalaureate/*methods
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - *Interprofessional Relations
MH  - Middle Aged
MH  - Midwifery/*education
MH  - *Nurse's Role
MH  - Pregnancy
MH  - Problem-Based Learning/methods
MH  - Students, Nursing/*psychology
MH  - Surveys and Questionnaires
MH  - Victoria
MH  - Young Adult
EDAT- 2010/05/19 06:00
MHDA- 2011/12/13 00:00
CRDT- 2010/05/19 06:00
PHST- 2009/08/22 00:00 [received]
PHST- 2009/12/14 00:00 [revised]
PHST- 2010/03/28 00:00 [accepted]
PHST- 2010/05/19 06:00 [entrez]
PHST- 2010/05/19 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0266-6138(10)00055-0 [pii]
AID - 10.1016/j.midw.2010.03.012 [doi]
PST - ppublish
SO  - Midwifery. 2011 Aug;27(4):503-8. doi: 10.1016/j.midw.2010.03.012. Epub 2010 May
      15.


PMID- 20478500
OWN - NLM
STAT- MEDLINE
DCOM- 20100913
LR  - 20211020
IS  - 1558-0490 (Electronic)
IS  - 1056-4993 (Linking)
VI  - 19
IP  - 2
DP  - 2010 Apr
TI  - Psychiatric issues in pediatric organ transplantation.
PG  - 285-300, viii-ix
LID - 10.1016/j.chc.2010.02.002 [doi]
AB  - Solid organ transplantation has become the first line of treatment for a growing 
      number of life-threatening pediatric illnesses. With improved survival, research 
      into the long-term outcome of transplant recipients has become important to
      clinicians. Adherence to medical instructions remains a challenge, particularly
      in the adolescent population. New immunosuppressant approaches promise to expand 
      organ transplantation in additional directions. Extension of transplantation into
      replacement of organs such as faces and hands raises complex ethical issues.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Stuber, Margaret L
AU  - Stuber ML
AD  - Department of Psychiatry and Biobehavioral Sciences, Semel Institute, David
      Geffen School of Medicine at UCLA, Los Angeles, CA 90024-1759, USA.
      mstuber@mednet.ucla.edu
LA  - eng
GR  - M01 RR000865-27S40674/RR/NCRR NIH HHS/United States
GR  - K07 AT003346/AT/NCCIH NIH HHS/United States
GR  - M01 RR000865/RR/NCRR NIH HHS/United States
GR  - K07 AT003346-04/AT/NCCIH NIH HHS/United States
GR  - R40 MC00120/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Child Adolesc Psychiatr Clin N Am
JT  - Child and adolescent psychiatric clinics of North America
JID - 9313451
SB  - IM
RPI - Pediatr Clin North Am. 2011 Aug;58(4):887-901, x. PMID: 21855712
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Guilt
MH  - Hospitalization/statistics & numerical data
MH  - Humans
MH  - Infant
MH  - Mental Disorders/diagnosis/*epidemiology/psychology
MH  - Organ Transplantation/*psychology/*statistics & numerical data
MH  - Patient Compliance/statistics & numerical data
MH  - Quality of Life/psychology
MH  - Suicide, Attempted/psychology/statistics & numerical data
MH  - Surveys and Questionnaires
MH  - Survival Rate
MH  - Young Adult
RF  - 78
PMC - PMC2873967
MID - NIHMS179023
EDAT- 2010/05/19 06:00
MHDA- 2010/09/14 06:00
CRDT- 2010/05/19 06:00
PHST- 2010/05/19 06:00 [entrez]
PHST- 2010/05/19 06:00 [pubmed]
PHST- 2010/09/14 06:00 [medline]
AID - S1056-4993(10)00012-X [pii]
AID - 10.1016/j.chc.2010.02.002 [doi]
PST - ppublish
SO  - Child Adolesc Psychiatr Clin N Am. 2010 Apr;19(2):285-300, viii-ix. doi:
      10.1016/j.chc.2010.02.002.


PMID- 20478372
OWN - NLM
STAT- MEDLINE
DCOM- 20101015
LR  - 20100712
IS  - 1873-3476 (Electronic)
IS  - 0378-5173 (Linking)
VI  - 395
IP  - 1-2
DP  - 2010 Aug 16
TI  - Specific aspects of gastro-intestinal transit in children for drug delivery
      design.
PG  - 37-43
LID - 10.1016/j.ijpharm.2010.04.048 [doi]
AB  - This mini-review discusses relevant aspects of gastro-intestinal transit in
      different ages of paediatric patients with an attempt to highlight factors which 
      should be considered in oral dosage form design, in particular multi-particulate 
      dosage forms. This emphasis is due to multi-particulates possessing many of the
      benefits of liquid oral formulations (such as ease of swallowing and dose
      adaptability) without many of their drawbacks (such as stability issues and lack 
      of enteric or modified release functionalities). It is commonly stated that
      children are not merely small adults with regards to medicines. However, there
      has been very little research regarding how different dosage forms transit
      through the gastro-intestinal tract in children compared to adults, due to both
      ethical and practical hurdles. Due to this lack of studies on dosage form transit
      in children, information which was available on the transit of food, milk and
      liquids (often dependent upon the age of the patient) has been used to look at
      how various aspects of transit vary with age and, where possible, when they reach
      adult values and how these may affect the fate of dosage forms in vivo:
      swallowability, oesophageal transit, gastric emptying and pH, intestinal and
      colonic transit are discussed.
CI  - Copyright (c) 2010 Elsevier B.V. All rights reserved.
FAU - Bowles, Alexandra
AU  - Bowles A
AD  - Department of Pharmaceutics, The School of Pharmacy, University of London, United
      Kingdom.
FAU - Keane, Joanne
AU  - Keane J
FAU - Ernest, Terry
AU  - Ernest T
FAU - Clapham, David
AU  - Clapham D
FAU - Tuleu, Catherine
AU  - Tuleu C
LA  - eng
PT  - Journal Article
DEP - 20100515
PL  - Netherlands
TA  - Int J Pharm
JT  - International journal of pharmaceutics
JID - 7804127
RN  - 0 (Dosage Forms)
RN  - 0 (Drug Carriers)
SB  - IM
MH  - Administration, Oral
MH  - Adult
MH  - Age Factors
MH  - Chemistry, Pharmaceutical
MH  - Child
MH  - Child, Preschool
MH  - Deglutition
MH  - *Dosage Forms
MH  - *Drug Carriers
MH  - Drug Compounding
MH  - *Gastrointestinal Transit
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Infant
EDAT- 2010/05/19 06:00
MHDA- 2010/10/16 06:00
CRDT- 2010/05/19 06:00
PHST- 2010/04/29 00:00 [received]
PHST- 2010/04/30 00:00 [accepted]
PHST- 2010/05/19 06:00 [entrez]
PHST- 2010/05/19 06:00 [pubmed]
PHST- 2010/10/16 06:00 [medline]
AID - S0378-5173(10)00345-5 [pii]
AID - 10.1016/j.ijpharm.2010.04.048 [doi]
PST - ppublish
SO  - Int J Pharm. 2010 Aug 16;395(1-2):37-43. doi: 10.1016/j.ijpharm.2010.04.048. Epub
      2010 May 15.


PMID- 20478360
OWN - NLM
STAT- MEDLINE
DCOM- 20101014
LR  - 20151119
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 479
IP  - 1
DP  - 2010 Jul 19
TI  - The effectiveness of EEG-feedback on attention, impulsivity and EEG: a sham
      feedback controlled study.
PG  - 49-53
LID - 10.1016/j.neulet.2010.05.026 [doi]
AB  - EEG-feedback, also called neurofeedback, is a training procedure aimed at
      altering brain activity, and is used as a treatment for disorders like Attention 
      Deficit/Hyperactivity Disorder (ADHD). Studies have reported positive effects of 
      neurofeedback on attention and other dependent variables. However, double-blind
      studies including a sham neurofeedback control group are lacking. The inclusion
      of such group is crucial to control for unspecific effects. The current work
      presents a sham-controlled, double-blind evaluation. The hypothesis was that
      neurofeedback enhances attention and decreases impulsive behavior. Participants
      (n=27) were students selected on relatively high scores on
      impulsivity/inattention questionnaires (Barrat Impulsivity Scale and Broadbent
      CFQ). They were assigned to a neurofeedback treatment or a sham group.
      (sham)Neurofeedback training was planned for 15 weeks consisting of a total of 30
      sessions, each lasting 22 min. Before and after 16 sessions (i.e., interim
      analyses), qEEG was recorded and impulsivity and inattention was assessed using a
      stop signal task and reversed continuous performance task and two questionnaires.
      Results of the interim analyses showed that participants were blind with respect 
      to group inclusion, but no trend towards an effect of neurofeedback on behavioral
      measures was observed. Therefore in line with ethical guidelines the experiment
      was ceased. These results implicate a possible lack of effect of neurofeedback
      when one accounts for non-specific effects. However, the specific form of
      feedback and application of the sham-controlled double-blind design may have
      diminished the effect of neurofeedback.
CI  - Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Logemann, H N Alexander
AU  - Logemann HN
AD  - Department of Experimental Psychology, Utrecht University, Utrecht, The
      Netherlands. H.N.A.Logemann@uu.nl
FAU - Lansbergen, Marieke M
AU  - Lansbergen MM
FAU - Van Os, Titus W D P
AU  - Van Os TW
FAU - Bocker, Koen B E
AU  - Bocker KB
FAU - Kenemans, J Leon
AU  - Kenemans JL
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20100515
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
SB  - IM
MH  - Attention/*physiology
MH  - Biofeedback, Psychology/*methods/*physiology
MH  - Brain/*physiology
MH  - Double-Blind Method
MH  - Electroencephalography/*methods
MH  - Female
MH  - Humans
MH  - Impulsive Behavior/*physiopathology
MH  - Male
MH  - Neuropsychological Tests
MH  - Surveys and Questionnaires
MH  - Time Factors
MH  - Young Adult
EDAT- 2010/05/19 06:00
MHDA- 2010/10/15 06:00
CRDT- 2010/05/19 06:00
PHST- 2010/02/04 00:00 [received]
PHST- 2010/05/07 00:00 [revised]
PHST- 2010/05/08 00:00 [accepted]
PHST- 2010/05/19 06:00 [entrez]
PHST- 2010/05/19 06:00 [pubmed]
PHST- 2010/10/15 06:00 [medline]
AID - S0304-3940(10)00601-4 [pii]
AID - 10.1016/j.neulet.2010.05.026 [doi]
PST - ppublish
SO  - Neurosci Lett. 2010 Jul 19;479(1):49-53. doi: 10.1016/j.neulet.2010.05.026. Epub 
      2010 May 15.


PMID- 20478240
OWN - NLM
STAT- MEDLINE
DCOM- 20100816
LR  - 20101005
IS  - 0040-5957 (Print)
IS  - 0040-5957 (Linking)
VI  - 65
IP  - 2
DP  - 2010 Mar-Apr
TI  - [Informed consent form for biomedical research: a tutorial for redaction].
PG  - 71-94
LID - 10.2515/therapie/2010006 [doi]
AB  - Since the full implementation in France of the European Directive 2001/20/EC
      about biomedical research, a written information form must be given to any
      participant in research, who must give in return his/her written consent. The
      written and consent form must be validated by a referent ethics committees prior 
      to the research, but guidelines for the redaction of such document are missing.
      Thus, the investigators who are often in charge of the redaction could be helped 
      by a tutorial that may consider the legal aspects, the rights of the participant 
      and the quality of information. For this, a group from the French network of the 
      clinical investigation centres--directed by the Inserm--worked on a tutorial
      which is presented here. This tutorial has been built stepwise, with review of
      the literature, enquiry within the French clinical investigation centres, primary
      redaction, internal validation, and final validation by external experts versed
      in the field of ethics for biomedical research.
CI  - 2010 Societe Francaise de Pharmacologie et de Therapeutique.
FAU - Henin, Yvette
AU  - Henin Y
AD  - Inserm CIC BT505, Paris, France.
FAU - de Boischevalier, Benedicte
AU  - de Boischevalier B
FAU - Reboul-Salze, Francoise
AU  - Reboul-Salze F
FAU - Cracowski, Jean-Luc
AU  - Cracowski JL
FAU - Duale, Christian
AU  - Duale C
CN  - Groupe de Travail "Ethique" du Reseau National des Centres d'Investigation
      Clinique
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Aide a la redaction du document ecrit destine a l'information du participant a la
      Recherche BioMedicale et a l'attestation de son consentement eclaire
DEP - 20100519
PL  - France
TA  - Therapie
JT  - Therapie
JID - 0420544
SB  - IM
EIN - Therapie. 2010 May-Jun;65(3):275. Chappuy, Helene [added]; Cornu, Catherine
      [added]; Costa, Yolande [added]; Deygas, Beatrice [added]; Dosquet, Christine
      [added]; Gueguen, Sonia [added]; Paris, Adeline [added]; Thalamas, Claire [added]
MH  - Biomedical Research/legislation & jurisprudence/*standards
MH  - Comprehension
MH  - Documentation/standards
MH  - *Editorial Policies
MH  - France
MH  - Humans
MH  - *Informed Consent
IR  - Chappuy H
FIR - Chappuy, Helene
IR  - Cornu C
FIR - Cornu, Catherine
IR  - Costa Y
FIR - Costa, Yolande
IR  - Deygas B
FIR - Deygas, Beatrice
IR  - Dosquet C
FIR - Dosquet, Christine
IR  - Gueguen S
FIR - Gueguen, Sonia
IR  - Paris A
FIR - Paris, Adeline
IR  - Thalamas C
FIR - Thalamas, Claire
EDAT- 2010/05/19 06:00
MHDA- 2010/08/17 06:00
CRDT- 2010/05/19 06:00
PHST- 2009/09/28 00:00 [received]
PHST- 2009/12/22 00:00 [accepted]
PHST- 2010/05/19 06:00 [entrez]
PHST- 2010/05/19 06:00 [pubmed]
PHST- 2010/08/17 06:00 [medline]
AID - 10.2515/therapie/2010006 [doi]
AID - th101818 [pii]
PST - ppublish
SO  - Therapie. 2010 Mar-Apr;65(2):71-94. doi: 10.2515/therapie/2010006. Epub 2010 May 
      19.


PMID- 20478022
OWN - NLM
STAT- MEDLINE
DCOM- 20120521
LR  - 20211028
IS  - 1471-2458 (Electronic)
IS  - 1471-2458 (Linking)
VI  - 10
DP  - 2010 May 17
TI  - Challenges in evaluating Welfare to Work policy interventions: would an RCT
      design have been the answer to all our problems?
PG  - 254
LID - 10.1186/1471-2458-10-254 [doi]
AB  - BACKGROUND: UK policy direction for recipients of unemployment and sickness
      benefits is to support these people into employment by increasing 'into work'
      interventions. Although the main aim of associated interventions is to increase
      levels of employment, improved health is stated as a benefit, and a driver of
      these interventions. This is therefore a potentially important policy
      intervention with respect to health and health inequalities, and needs to be
      validated through rigorous impact evaluation.We attempted to evaluate the
      Pathways Advisory Service intervention which aims to provide employment support
      for Incapacity Benefit recipients, but encountered a number of challenges and
      barriers to evaluation. This paper explores the issues that arose in designing a 
      suitable evaluation of the Pathways Advisory Service. DISCUSSION: The main issues
      that arose were that characteristics of the intervention lead to difficulties in 
      defining a suitable comparison group; and governance restrictions such as
      uncertainty regarding ethical consent processes and data sharing between agencies
      for research. Some of these challenges threatened fundamentally to limit the
      validity of any experimental or quasi-experimental evaluation we could design -
      restricting recruitment, data collection and identification of an appropriate
      comparison group. Although a cluster randomised controlled trial design was
      ethically justified to evaluate the Pathways Advisory Service, this was not
      possible because the intervention was already being widely implemented. However, 
      this would not have solved other barriers to evaluation. There is no obvious
      method to perform a controlled evaluation for interventions where only a small
      proportion of those eligible are exposed. Improved communication between
      policymakers and researchers, clarification of data sharing protocols and
      improved guidelines for ethics committees are tangible ways which may reduce the 
      current obstacles to this and other similar evaluations of policy interventions
      which tackle key determinants of health. SUMMARY: The evaluation of social
      interventions is hampered by more than their suitability to randomisation. Data
      sharing, participant identification and recruitment problems are common to
      randomised and non-randomised evaluation designs. These issues require further
      attention if we are to learn from current social policy.
FAU - Skivington, Kathryn
AU  - Skivington K
AD  - MRC Social and Public Health Sciences Unit, 4 Lilybank Gardens, Glasgow, G12 8RZ,
      UK. kathryn@sphsu.mrc.ac.uk
FAU - McCartney, Gerry
AU  - McCartney G
FAU - Thomson, Hilary
AU  - Thomson H
FAU - Bond, Lyndal
AU  - Bond L
LA  - eng
GR  - MC_U130059812/MRC_/Medical Research Council/United Kingdom
GR  - SPHSU1/CSO_/Chief Scientist Office/United Kingdom
PT  - Comparative Study
PT  - Journal Article
DEP - 20100517
PL  - England
TA  - BMC Public Health
JT  - BMC public health
JID - 100968562
SB  - IM
MH  - Adult
MH  - Consultants/legislation & jurisprudence
MH  - Data Collection/ethics/standards
MH  - Employment/*legislation & jurisprudence
MH  - Female
MH  - Healthcare Disparities/standards
MH  - Humans
MH  - Male
MH  - Policy Making
MH  - Program Development/*methods
MH  - Randomized Controlled Trials as Topic
MH  - Research Design
MH  - *Social Welfare
MH  - United Kingdom
PMC - PMC2882350
EDAT- 2010/05/19 06:00
MHDA- 2012/05/23 06:00
CRDT- 2010/05/19 06:00
PHST- 2009/10/21 00:00 [received]
PHST- 2010/05/17 00:00 [accepted]
PHST- 2010/05/19 06:00 [entrez]
PHST- 2010/05/19 06:00 [pubmed]
PHST- 2012/05/23 06:00 [medline]
AID - 1471-2458-10-254 [pii]
AID - 10.1186/1471-2458-10-254 [doi]
PST - epublish
SO  - BMC Public Health. 2010 May 17;10:254. doi: 10.1186/1471-2458-10-254.


PMID- 20476621
OWN - NLM
STAT- MEDLINE
DCOM- 20100614
LR  - 20100518
IS  - 1461-3123 (Print)
IS  - 1461-3123 (Linking)
VI  - 13
IP  - 4
DP  - 2010 Apr
TI  - Midwifery basics: understanding research (6). Research ethics.
PG  - 34-7
FAU - Healy, Patricia
AU  - Healy P
AD  - School of Nursing and Midwifery, National University of Ireland, Galway.
FAU - Fallon, Anne
AU  - Fallon A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Pract Midwife
JT  - The practising midwife
JID - 9814758
MH  - Delivery, Obstetric/nursing
MH  - *Ethics, Research
MH  - Evidence-Based Medicine/*education/*ethics
MH  - Evidence-Based Nursing/*ethics/organization & administration
MH  - Humans
MH  - Midwifery/*education/*ethics
MH  - Nursing Methodology Research/ethics
MH  - Practice Guidelines as Topic
RF  - 28
EDAT- 2010/05/19 06:00
MHDA- 2010/06/15 06:00
CRDT- 2010/05/19 06:00
PHST- 2010/05/19 06:00 [entrez]
PHST- 2010/05/19 06:00 [pubmed]
PHST- 2010/06/15 06:00 [medline]
PST - ppublish
SO  - Pract Midwife. 2010 Apr;13(4):34-7.


PMID- 20476523
OWN - NLM
STAT- MEDLINE
DCOM- 20100617
LR  - 20100518
IS  - 1092-0811 (Print)
IS  - 1092-0811 (Linking)
VI  - 19
IP  - 2
DP  - 2010 Mar-Apr
TI  - Physician-assisted suicide: compassionate liberation or murder?
PG  - 121-5
AB  - PAS is legal only in Oregon, Washington, and Montana. Studies show nurses receive
      requests for aid in dying from patients (Asch, 1996; Ferrell et al., 2000: Kuhse 
      & Singer, 1993; Schwarz, 2003; Volker, 2003; Wurzbach, 2000). The simple answer
      to these requests is that the nurse is prohibited in participating in assisted
      suicide or euthanasia by the Code of Ethics for Nurses and by the ANA position
      statements (ANA, 1994). In this article, the author attempted to present a
      balanced view of the ethical issues on both sides of the question of PAS.
      Honoring the autonomy of a patient does not require participation in PAS.
      However, nurses who support PAS speak of the patient's autonomous choice and
      their choice to assist in ending suffering of terminally ill patients. As more
      states pass ballot initiatives or laws supporting PAS, nurses will be faced with 
      the legal choice to participate in the process of PAS by providing information on
      the option and attending to the patient who has taken the lethal drug. Nurses
      need to consider their comfort with the idea that patients may choose to
      accelerate dying.
FAU - Lachman, Vicki
AU  - Lachman V
AD  - Drexel University, Philadelphia, PA, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medsurg Nurs
JT  - Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses
JID - 9300545
MH  - Choice Behavior
MH  - Codes of Ethics
MH  - Humans
MH  - *Nurse's Role
MH  - Oregon
MH  - Patient Acceptance of Health Care
MH  - Practice Guidelines as Topic
MH  - *Right to Die/ethics/legislation & jurisprudence
MH  - *Suicide, Assisted/ethics/legislation & jurisprudence
MH  - Terminal Care/ethics/legislation & jurisprudence
MH  - United States
MH  - Washington
EDAT- 2010/05/19 06:00
MHDA- 2010/06/18 06:00
CRDT- 2010/05/19 06:00
PHST- 2010/05/19 06:00 [entrez]
PHST- 2010/05/19 06:00 [pubmed]
PHST- 2010/06/18 06:00 [medline]
PST - ppublish
SO  - Medsurg Nurs. 2010 Mar-Apr;19(2):121-5.


PMID- 20476517
OWN - NLM
STAT- MEDLINE
DCOM- 20100617
LR  - 20101230
IS  - 1092-0811 (Print)
IS  - 1092-0811 (Linking)
VI  - 19
IP  - 2
DP  - 2010 Mar-Apr
TI  - Professional work ethic: strategies to motivate bedside nurses to deliver
      high-quality patient care.
PG  - 85-9
FAU - Bartzak, Patricia J
AU  - Bartzak PJ
AD  - Transplant/Burn/ Trauma Unit, Brigham & Women's Hospital, Boston, MA, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medsurg Nurs
JT  - Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses
JID - 9300545
CIN - Medsurg Nurs. 2010 Sep-Oct;19(5):272. PMID: 21189739
MH  - *Attitude of Health Personnel
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Interprofessional Relations
MH  - Leadership
MH  - Models, Nursing
MH  - *Motivation
MH  - *Nurse Administrators/organization & administration/psychology
MH  - Nurse's Role/psychology
MH  - Nursing Staff, Hospital/education/ethics/organization &
      administration/*psychology
MH  - Nursing, Supervisory/organization & administration
MH  - Patient Satisfaction
MH  - *Professional Competence
MH  - Quality Assurance, Health Care/ethics/*organization & administration
MH  - Social Support
MH  - Thinking
EDAT- 2010/05/19 06:00
MHDA- 2010/06/18 06:00
CRDT- 2010/05/19 06:00
PHST- 2010/05/19 06:00 [entrez]
PHST- 2010/05/19 06:00 [pubmed]
PHST- 2010/06/18 06:00 [medline]
PST - ppublish
SO  - Medsurg Nurs. 2010 Mar-Apr;19(2):85-9.


PMID- 20473477
OWN - NLM
STAT- MEDLINE
DCOM- 20101005
LR  - 20191210
IS  - 1795-990X (Electronic)
IS  - 0355-3140 (Linking)
VI  - 36
IP  - 4
DP  - 2010 Jun
TI  - Economic evaluations of occupational health interventions from a corporate
      perspective - a systematic review of methodological quality.
PG  - 273-88
AB  - OBJECTIVE: Using a standardized quality criteria list, we appraised the
      methodological quality of economic evaluations of occupational safety and health 
      (OSH) interventions conducted from a corporate perspective. METHODS: The primary 
      literature search was conducted in Medline and Embase. Supplemental searches were
      conducted in the Cochrane NHS Economic Evaluation Database, the National
      Institute for Occupational Safety and Health (NIOSH) database, the Ryerson
      International Labour, Occupational Safety and Health Index, scans of reference
      lists, and researchers' own literature database. Independently, two researchers
      selected articles based on title, keywords, and abstract, and if needed,
      fulltext. Disagreements were resolved by a consensus procedure. Articles were
      selected based on seven criteria addressing study population, type of
      intervention, comparative intervention, outcome, costs, language, and
      perspective. Two reviewers independently judged methodological quality using the 
      Consensus on Health Economic Criteria (CHEC-list), a 19-item standardized quality
      criteria list. Disagreements in judgment were also resolved by consensus. Data
      were analyzed descriptively. RESULTS: A total of 34 studies were included. Of
      these, only 44% of the studies met more than 50% of the quality criteria. Of the 
      19 quality criteria, 8 were met by 50% or more of the studies. The 11 least
      fulfilled criteria related to (i) performance of a sensitivity analysis, (ii)
      selection of perspective, (iii) description of study population, (iv) discussion 
      of generalizability, (v) description of competing alternatives, (vi) presentation
      of the research question, (vii) measurement of outcomes, (viii) measurement of
      costs, (ix) valuation of costs, (x) declaration of researchers' independence, and
      (xi) discussion of ethical and distributional issues. CONCLUSIONS: Apart from a
      few exceptions, the overall methodological quality of the economic evaluations of
      OSH interventions from a corporate perspective was poor. As such, there is a risk
      of biased results. The quality of future evaluations needs to be improved to
      increase the validity of their conclusions and recommendations.
FAU - Uegaki, Kimi
AU  - Uegaki K
AD  - Health Technology Assessment Unit, EMGO Institute for Health and Care Research,
      VU University Medical Center, Amsterdam, the Netherlands. kimi.uegaki@falw.vu.nl
FAU - de Bruijne, Martine C
AU  - de Bruijne MC
FAU - Lambeek, Ludeke
AU  - Lambeek L
FAU - Anema, Johannes R
AU  - Anema JR
FAU - van der Beek, Allard J
AU  - van der Beek AJ
FAU - van Mechelen, Willem
AU  - van Mechelen W
FAU - van Tulder, Maurits W
AU  - van Tulder MW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20100517
PL  - Finland
TA  - Scand J Work Environ Health
JT  - Scandinavian journal of work, environment & health
JID - 7511540
SB  - IM
MH  - *Costs and Cost Analysis
MH  - National Institute for Occupational Safety and Health, U.S.
MH  - *Occupational Health
MH  - State Medicine
MH  - United Kingdom
MH  - United States
RF  - 60
EDAT- 2010/05/18 06:00
MHDA- 2010/10/06 06:00
CRDT- 2010/05/18 06:00
PHST- 2010/05/18 06:00 [entrez]
PHST- 2010/05/18 06:00 [pubmed]
PHST- 2010/10/06 06:00 [medline]
AID - 3017 [pii]
AID - 10.5271/sjweh.3017 [doi]
PST - ppublish
SO  - Scand J Work Environ Health. 2010 Jun;36(4):273-88. doi: 10.5271/sjweh.3017. Epub
      2010 May 17.


PMID- 20473194
OWN - NLM
STAT- MEDLINE
DCOM- 20100607
LR  - 20151119
IS  - 1537-1948 (Electronic)
IS  - 0025-7079 (Linking)
VI  - 48
IP  - 6
DP  - 2010 Jun
TI  - When the patient does not pay: a survey of primary care physicians.
PG  - 498-502
LID - 10.1097/MLR.0b013e3181dbe932 [doi]
AB  - OBJECTIVE: Despite ethical implications, there are anecdotal reports of health
      practitioners withholding services from patients who do not pay their bills. We
      surveyed physicians about their attitudes and experiences regarding nonpaying
      patients. DESIGN: A cross-sectional mailed survey. PARTICIPANTS: Three hundred
      seventy-nine of 1000 surveyed primary care physicians participated. MEASUREMENTS 
      AND MAIN RESULTS: We studied how likely participants were to withhold 13 services
      from hypothetical patients who did not pay the physician's bills based on a
      4-point Likert scale. Respondents were asked whether they had actually ever
      withheld such services from patients. The effects of demographic data on the
      number of services withheld from hypothetical and actual patients were analyzed
      by analysis of variance and multiple logistic regression. Most respondents (84%) 
      would have withheld at least 1 item of service from the hypothetical patient,
      with 41% having ever withheld care from their actual patients. Most services
      involved administrative actions, but many respondents would be willing to forego 
      other types of medical care. Being younger (P = 0.003), believing that patients
      are not always entitled to medical care (P = 0.002) and being in an urban
      practice (P = 0.03) were associated with withholding medical care from patients. 
      CONCLUSIONS: A majority of primary care practitioners responding to our survey
      would be willing to withhold medical care from patients who do not pay their
      bills; some have actually done so despite ethical and legal mandates to the
      contrary. Physicians should be educated about the importance of the
      patient-physician relationship and their ethical obligations to patients.
FAU - Farber, Neil J
AU  - Farber NJ
AD  - Department of Medicine, University of California-San Diego, 9350 Campus Point
      Drive, La Jolla, CA 92037, USA. nfarber@ucsd.edu
FAU - Roche, Charles V 3rd
AU  - Roche CV 3rd
FAU - Aboff, Brian M
AU  - Aboff BM
FAU - Collier, Virginia U
AU  - Collier VU
FAU - Weiner, Joan
AU  - Weiner J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Care
JT  - Medical care
JID - 0230027
SB  - IM
CIN - Med Care. 2010 Jun;48(6):495-7. PMID: 20473187
MH  - Adult
MH  - Aged
MH  - *Attitude of Health Personnel
MH  - Cross-Sectional Studies
MH  - Ethics, Medical
MH  - Family Practice/*economics/ethics/*statistics & numerical data
MH  - Fees, Medical/ethics/*statistics & numerical data
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Physician-Patient Relations
MH  - Population Surveillance
MH  - Practice Patterns, Physicians'/ethics/*statistics & numerical data
MH  - Primary Health Care/economics/ethics/*statistics & numerical data
MH  - Quality of Health Care
MH  - Refusal to Treat/ethics/*statistics & numerical data
MH  - Uncompensated Care/economics/ethics/*statistics & numerical data
MH  - United States/epidemiology
EDAT- 2010/05/18 06:00
MHDA- 2010/06/09 06:00
CRDT- 2010/05/18 06:00
PHST- 2010/05/18 06:00 [entrez]
PHST- 2010/05/18 06:00 [pubmed]
PHST- 2010/06/09 06:00 [medline]
AID - 10.1097/MLR.0b013e3181dbe932 [doi]
PST - ppublish
SO  - Med Care. 2010 Jun;48(6):498-502. doi: 10.1097/MLR.0b013e3181dbe932.


PMID- 20473187
OWN - NLM
STAT- MEDLINE
DCOM- 20100607
LR  - 20151119
IS  - 1537-1948 (Electronic)
IS  - 0025-7079 (Linking)
VI  - 48
IP  - 6
DP  - 2010 Jun
TI  - Non-payment and non-care: ethics and continuity of care.
PG  - 495-7
LID - 10.1097/MLR.0b013e3181e1c330 [doi]
FAU - Stone, John R
AU  - Stone JR
LA  - eng
PT  - Comment
PT  - Editorial
PL  - United States
TA  - Med Care
JT  - Medical care
JID - 0230027
SB  - IM
CON - Med Care. 2010 Jun;48(6):498-502. PMID: 20473194
MH  - *Attitude of Health Personnel
MH  - Continuity of Patient Care/*ethics
MH  - Ethics, Medical
MH  - Fees, Medical/*ethics
MH  - Humans
MH  - Physician-Patient Relations/*ethics
MH  - Practice Patterns, Physicians'/*ethics
MH  - Primary Health Care/ethics
MH  - Refusal to Treat/*ethics
MH  - United States/epidemiology
EDAT- 2010/05/18 06:00
MHDA- 2010/06/09 06:00
CRDT- 2010/05/18 06:00
PHST- 2010/05/18 06:00 [entrez]
PHST- 2010/05/18 06:00 [pubmed]
PHST- 2010/06/09 06:00 [medline]
AID - 10.1097/MLR.0b013e3181e1c330 [doi]
PST - ppublish
SO  - Med Care. 2010 Jun;48(6):495-7. doi: 10.1097/MLR.0b013e3181e1c330.


PMID- 20473071
OWN - NLM
STAT- MEDLINE
DCOM- 20110125
LR  - 20211020
IS  - 1533-712X (Electronic)
IS  - 0271-0749 (Linking)
VI  - 30
IP  - 3
DP  - 2010 Jun
TI  - Survey of investigators' opinions on the acceptability of interactions with
      patients participating in clinical trials.
PG  - 323-7
LID - 10.1097/JCP.0b013e3181dc6b3e [doi]
AB  - INTRODUCTION: There is growing concern about the ability of clinical trials to
      reliably detect differences between active drugs and placebo. To date, little
      attention has focused on how interactions between clinical trial investigators
      and patients may influence study outcomes. We sought to explore what types of
      interactions with patients investigators considered to be appropriate during
      placebo-controlled pharmacotherapy studies of major depressive disorder. METHODS:
      Questionnaires describing 26 specific types of clinician-patient interactions
      were administered to principal investigators (PIs) attending an investigators
      meeting for a phase 3 clinical trial of an antidepressant medication. Principal
      investigators were asked to rate the acceptability of each intervention. They
      were also asked to report the mean time they spent with patients at a midstudy
      visit. Principal investigators were grouped according to previous trial
      experiences (participation in <20 or > or =20 prior trials). RESULTS: Principal
      investigators generally agreed that physical health recommendations and
      nonspecific interactions with study patients were acceptable. Relating the
      investigator's personal experiences and siding with the patient on interpersonal 
      conflicts were consistently rated as unacceptable. Less-experienced PIs were
      significantly more likely to view as acceptable cognitive, behavioral, and
      emotionally supportive interventions compared with more-experienced PIs.
      Forty-two percent of PIs reported spending at least 20 minutes with patients at
      midstudy visits. CONCLUSIONS: There is significant variability between PIs in
      what are considered to be appropriate interactions with patients participating in
      clinical trials. Greater standardization of these interactions is required to
      reduce placebo response rates and to strengthen the ethical conduct of clinical
      trials.
FAU - Dunlop, Boadie W
AU  - Dunlop BW
AD  - Department of Psychiatry and Behavioral Sciences, Emory University School of
      Medicine, Atlanta, GA 30322, USA. bdunlop@emory.edu
FAU - Vaughan, Christopher L
AU  - Vaughan CL
LA  - eng
GR  - KL2 TR000455/TR/NCATS NIH HHS/United States
GR  - K12 RR017643/RR/NCRR NIH HHS/United States
GR  - K23 MH086690/MH/NIMH NIH HHS/United States
GR  - KL2 RR025009/RR/NCRR NIH HHS/United States
GR  - K12 RR 017643/RR/NCRR NIH HHS/United States
GR  - UL1 TR000454/TR/NCATS NIH HHS/United States
GR  - 1KL2RR025009/RR/NCRR NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Clin Psychopharmacol
JT  - Journal of clinical psychopharmacology
JID - 8109496
SB  - IM
MH  - Clinical Trials, Phase III as Topic/*ethics/standards
MH  - *Data Collection
MH  - Depressive Disorder, Major/therapy
MH  - Humans
MH  - Multicenter Studies as Topic/*ethics/standards
MH  - Physician-Patient Relations/*ethics
MH  - Randomized Controlled Trials as Topic/*ethics/standards
MH  - Research Personnel/*ethics/standards
MH  - Time Factors
PMC - PMC3721194
MID - NIHMS486552
EDAT- 2010/05/18 06:00
MHDA- 2011/01/28 06:00
CRDT- 2010/05/18 06:00
PHST- 2010/05/18 06:00 [entrez]
PHST- 2010/05/18 06:00 [pubmed]
PHST- 2011/01/28 06:00 [medline]
AID - 10.1097/JCP.0b013e3181dc6b3e [doi]
AID - 00004714-201006000-00018 [pii]
PST - ppublish
SO  - J Clin Psychopharmacol. 2010 Jun;30(3):323-7. doi: 10.1097/JCP.0b013e3181dc6b3e.


PMID- 20473064
OWN - NLM
STAT- MEDLINE
DCOM- 20110125
LR  - 20211028
IS  - 1533-712X (Electronic)
IS  - 0271-0749 (Linking)
VI  - 30
IP  - 3
DP  - 2010 Jun
TI  - Early onset of antipsychotic action in schizophrenia: evaluating the possibility 
      of shorter acute efficacy trials.
PG  - 286-9
LID - 10.1097/JCP.0b013e3181dcb7c3 [doi]
AB  - Extended placebo-controlled clinical trials in schizophrenia research pose an
      ethical challenge. This study examines factors that have implications for the
      design and duration of placebo-controlled acute efficacy trials: Does early
      response discriminate active drug (AD) from placebo, and are the early
      differences sustained over time? A post hoc pooled analysis of 2 randomized
      6-week double-blind clinical trials was performed comparing patients with
      schizophrenia treated with placebo or low-dose olanzapine (1 mg/d; placebo/low
      dose [PBO] group, n = 170) to patients treated with a 10- to 20-mg/d dose of
      haloperidol or medium- to high-dose olanzapine (7.5 to 17.5 mg/d; AD group, n =
      252). Mixed-model repeated-measure analysis tested for group differences. Power
      analysis was undertaken to compare study designs with shorter durations. At 2
      weeks, the mean reduction in the Brief Psychiatric Rating Scale total score was
      significantly greater for the AD group (-10.1) compared with the PBO group (-4.1;
      P < 0.001); this difference was sustained until the study ended (6 weeks). A
      higher proportion of early treatment responders were observed for the AD group
      (52%) compared with the PBO group (29%; P < 0.001). Early nonresponse to placebo 
      or drug was predictive of subsequent nonresponse (negative predictive value: PBO 
      = 95%, AD = 84%). Power analysis indicates that the placebo-drug differences are 
      robust at 2 weeks. Treatment responders from the AD and the PBO groups followed a
      similar response path. Early response to antipsychotic treatment discriminated AD
      from placebo. Reducing placebo-controlled clinical trials from 6 weeks to 2 to 4 
      weeks was found to be a viable option for efficacy identification in acutely ill 
      patients.
FAU - Kinon, Bruce J
AU  - Kinon BJ
AD  - Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center,
      Indianapolis, IN 46285, USA. Kinon_Bruce@Lilly.com
FAU - Chen, Lei
AU  - Chen L
FAU - Stauffer, Virginia L
AU  - Stauffer VL
FAU - Sniadecki, Jennifer
AU  - Sniadecki J
FAU - Ascher-Svanum, Haya
AU  - Ascher-Svanum H
FAU - Kollack-Walker, Sara
AU  - Kollack-Walker S
FAU - Jacob, Jayanthi
AU  - Jacob J
FAU - Kapur, Shitij
AU  - Kapur S
LA  - eng
GR  - G0701748/MRC_/Medical Research Council/United Kingdom
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Psychopharmacol
JT  - Journal of clinical psychopharmacology
JID - 8109496
RN  - 0 (Antipsychotic Agents)
SB  - IM
MH  - Adult
MH  - Antipsychotic Agents/*therapeutic use
MH  - Brief Psychiatric Rating Scale
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Male
MH  - Randomized Controlled Trials as Topic/*methods
MH  - Sample Size
MH  - Schizophrenia/*drug therapy/epidemiology
MH  - *Schizophrenic Psychology
MH  - Statistics as Topic/methods
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2010/05/18 06:00
MHDA- 2011/01/28 06:00
CRDT- 2010/05/18 06:00
PHST- 2010/05/18 06:00 [entrez]
PHST- 2010/05/18 06:00 [pubmed]
PHST- 2011/01/28 06:00 [medline]
AID - 10.1097/JCP.0b013e3181dcb7c3 [doi]
AID - 00004714-201006000-00011 [pii]
PST - ppublish
SO  - J Clin Psychopharmacol. 2010 Jun;30(3):286-9. doi: 10.1097/JCP.0b013e3181dcb7c3.


PMID- 20471780
OWN - NLM
STAT- MEDLINE
DCOM- 20101102
LR  - 20161209
IS  - 2213-0276 (Electronic)
IS  - 0755-4982 (Linking)
VI  - 39
IP  - 10
DP  - 2010 Oct
TI  - [Management of the hunger strike in prison].
PG  - e217-22
LID - 10.1016/j.lpm.2010.01.012 [doi]
AB  - INTRODUCTION: Entering prison can feed pre-existent behavior of demands or
      generate them. Several means of expression are then used. Hunger strike is an
      average privileged act. It belongs to prison culture. OBJECTIVE: Estimate how
      practitioners working in prison take care of the hunger strikers. METHODOLOGY:
      The study, realised in 2008, was led with all the Units of Consultations and
      Ambulatory Care in France. It is a declarative investigation where a medical
      testimony by unit was asked. RESULTS: From 174 "maisons d'arret" and
      establishments for punishment in France, 95 answers were obtained. This situation
      was already seen by 98,8% of the doctors. The motives for hunger strike were
      mainly judicial for "maisons d'arret" (70,1%) and prison motives for detention
      centers (68,7%). Mainly, doctors opted for a neutral attitude (63% of the cases).
      The hunger strikes were mostly brief (less than a week in 85% of the cases). Only
      5,5% of the doctors proposed written information concerning the risks incurred
      during a fast. A doctor in 4 approximately (23%) was already witness to
      complications due to fasting. The fact that a patient may refuse care makes the
      medical approach difficult. Faced with such a situation, 45% of the doctors
      privileged their duty of care, 28% respected the patient's wishes, and 27% did
      not pronounce. From a therapeutic point of view, the place of treatment using
      vitamins was rarely recognized (32,7%). DISCUSSION: Hunger strike is rarely
      severe, but it is rather frequent in prison so that every doctor working there
      will be confronted with it. The refeeding syndrome seems often ignored. The
      coverage of hunger strike is governed by the law, but ethical questions stay in
      the appreciation of every doctor.
CI  - Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
FAU - Fayeulle, Stephanie
AU  - Fayeulle S
AD  - Service de medecine interne, maladies infectieuses, UCSA, centre hospitalier
      regional Felix-Guyon, 97400 Saint-Denis, Reunion. s.fayeulle@gmail.com
FAU - Renou, Frederic
AU  - Renou F
FAU - Protais, Emmanuel
AU  - Protais E
FAU - Hedouin, Valery
AU  - Hedouin V
FAU - Wartel, Guillaume
AU  - Wartel G
FAU - Yvin, Jean-Luc
AU  - Yvin JL
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Prise en charge medicale de la greve de la faim en milieu carceral.
DEP - 20100514
PL  - France
TA  - Presse Med
JT  - Presse medicale (Paris, France : 1983)
JID - 8302490
SB  - IM
MH  - Adult
MH  - Ambulatory Care/ethics/*organization & administration
MH  - Attitude of Health Personnel
MH  - Fasting/*adverse effects/physiology/psychology
MH  - Female
MH  - France/epidemiology
MH  - Hospitalization/statistics & numerical data
MH  - Humans
MH  - Male
MH  - *Medical Staff/ethics/organization & administration/psychology
MH  - Motivation
MH  - Nutritional Support
MH  - Patient Advocacy
MH  - Patient Education as Topic
MH  - Physician's Role/psychology
MH  - Practice Patterns, Physicians'/ethics/*organization & administration
MH  - Prisoners/education/legislation & jurisprudence/psychology/*statistics &
      numerical data
MH  - Prisons/ethics/*organization & administration
MH  - Refeeding Syndrome/etiology/prevention & control
MH  - Starvation/epidemiology/etiology/therapy
MH  - Surveys and Questionnaires
MH  - Treatment Refusal
EDAT- 2010/05/18 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/05/18 06:00
PHST- 2009/09/10 00:00 [received]
PHST- 2009/12/21 00:00 [revised]
PHST- 2010/01/12 00:00 [accepted]
PHST- 2010/05/18 06:00 [entrez]
PHST- 2010/05/18 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - S0755-4982(10)00274-5 [pii]
AID - 10.1016/j.lpm.2010.01.012 [doi]
PST - ppublish
SO  - Presse Med. 2010 Oct;39(10):e217-22. doi: 10.1016/j.lpm.2010.01.012. Epub 2010
      May 14.


PMID- 20471722
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20211020
IS  - 1578-1275 (Electronic)
IS  - 0212-6567 (Linking)
VI  - 42
IP  - 8
DP  - 2010 Aug
TI  - [Clinical relationships and ethical problems in primary care, Sao Paulo, SP,
      Brazil].
PG  - 406-12
LID - 10.1016/j.aprim.2010.01.018 [doi]
AB  - OBJECTIVES: MAIN OBJECTIVE: to identify ethical problems in primary care
      according to nurses' and doctors' perceptions. SECONDARY OBJECTIVE: to know
      ethical issues of patient-professional relationships in primary care. DESIGN:
      Synthesis to integrate and reinterpret primary results of qualitative studies.
      SETTING: Primary healthcare centers, Sao Paulo, SP, Brazil. PARTICIPANTS AND/OR
      CONTEXT: Incidental sample of 34 nurses and 36 medical doctors working in primary
      healthcare centers selected by convenience. METHODS: Individual, semi-structured 
      interviews to identity situations considered as sources of ethical problems. The 
      sample is socially representative of primary care health centers and
      professionals. Data collection assured discourse saturation.
      Hermeneutic-dialectical discourse analysis was used to study the results.
      RESULTS: Patient-professional relationships and team work were the main sources
      of ethical problems. The most important problems were patient information,
      privacy, confidentiality, interpersonal relationship, linkage and patient
      autonomy. These issues reflect the recent changes in clinical relation ships and 
      show the peculiarities of primary care with its continuous care which lasts a
      long time. Healthcare involves multiprofessional team work in the midst of the
      patient claims for autonomy. Good care of patients needs requires a relationship 
      based on communication and cooperation, and includes feelings and values, with
      communication skills. CONCLUSIONS: Ethical problems in primary care are common
      situations. For quality and humane primary care the relationship should consist
      of dialogue, trust and cooperation.
CI  - Copyright 2009 Elsevier Espana, S.L. All rights reserved.
FAU - Campos Pavone Zoboli, Elma Lourdes
AU  - Campos Pavone Zoboli EL
AD  - Escuela de Enfermeria, Universidad de Sao Paulo, Sao Paulo, Brasil.
      crzoboli@vivax.com.br
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
TT  - Relacion clinica y problemas eticos en atencion primaria, Sao Paulo, Brasil.
DEP - 20100514
PL  - Spain
TA  - Aten Primaria
JT  - Atencion primaria
JID - 9111075
SB  - IM
CIN - Aten Primaria. 2010 Aug;42(8):412-4. PMID: 20576323
MH  - Brazil
MH  - *Physician-Nurse Relations
MH  - Primary Health Care/*ethics
PMC - PMC7024516
EDAT- 2010/05/18 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/05/18 06:00
PHST- 2009/06/25 00:00 [received]
PHST- 2009/12/07 00:00 [revised]
PHST- 2010/01/21 00:00 [accepted]
PHST- 2010/05/18 06:00 [entrez]
PHST- 2010/05/18 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S0212-6567(10)00108-3 [pii]
AID - 10.1016/j.aprim.2010.01.018 [doi]
PST - ppublish
SO  - Aten Primaria. 2010 Aug;42(8):406-12. doi: 10.1016/j.aprim.2010.01.018. Epub 2010
      May 14.


PMID- 20471316
OWN - NLM
STAT- MEDLINE
DCOM- 20101026
LR  - 20181201
IS  - 1618-131X (Electronic)
IS  - 1438-4639 (Linking)
VI  - 213
IP  - 4
DP  - 2010 Jul
TI  - What is the use? An international look at reuse of single-use medical devices.
PG  - 302-7
LID - 10.1016/j.ijheh.2010.04.003 [doi]
AB  - Reuse of single-use devices is common in most countries worldwide. We provide an 
      overview of the issue from an international perspective. In many developing and
      transitional countries reuse of cheap single-use devices (needles, syringes,
      surgical gloves) is common leading to large numbers of unsafe interventions,
      specifically injections and, as a consequence, infection with hepatitis B, C or
      HIV. There are various reasons for reuse: limited resources, insufficient
      knowledge of healthcare workers and the belief of patients that injection is more
      beneficial than oral medication. Reuse of cheap single-use devices should cease
      and both medical staff and the public should be informed about potential safety
      risks associated with injection. In developed countries, reuse of single-use
      items is less common but may include expensive technical products. Reuse is
      regulated in many countries (e.g. US, Canada, some European countries) demanding 
      ethical and legal considerations, high standards of reprocessing and training of 
      staff, risk assessment, management and validation of reprocessing. Well regulated
      reprocessing can decrease the number of single-use devices reprocessed. In
      developing as well as developed countries, a decision to reprocess single-use
      devices should only be made after a critical reflection of advantages and
      disadvantages.
CI  - Copyright 2010 Elsevier GmbH. All rights reserved.
FAU - Popp, Walter
AU  - Popp W
AD  - Hospital Hygiene, University Clinics of Essen, Hufelandstr. 55, 45122 Essen,
      Germany. Walter.popp@uk-essen.de
FAU - Rasslan, Ossama
AU  - Rasslan O
FAU - Unahalekhaka, Akeau
AU  - Unahalekhaka A
FAU - Brenner, Pola
AU  - Brenner P
FAU - Fischnaller, Edith
AU  - Fischnaller E
FAU - Fathy, Maha
AU  - Fathy M
FAU - Goldman, Carol
AU  - Goldman C
FAU - Gillespie, Elizabeth
AU  - Gillespie E
LA  - eng
PT  - Journal Article
DEP - 20100513
PL  - Germany
TA  - Int J Hyg Environ Health
JT  - International journal of hygiene and environmental health
JID - 100898843
SB  - IM
MH  - Africa
MH  - Asia
MH  - Australia
MH  - Canada
MH  - Cross Infection/epidemiology
MH  - Disposable Equipment/*standards/statistics & numerical data
MH  - Equipment Reuse/standards
MH  - Equipment Safety
MH  - Europe
MH  - Humans
MH  - Middle East
MH  - Risk Assessment
MH  - Sterilization
MH  - United States
EDAT- 2010/05/18 06:00
MHDA- 2010/10/27 06:00
CRDT- 2010/05/18 06:00
PHST- 2009/07/27 00:00 [received]
PHST- 2010/04/13 00:00 [revised]
PHST- 2010/04/13 00:00 [accepted]
PHST- 2010/05/18 06:00 [entrez]
PHST- 2010/05/18 06:00 [pubmed]
PHST- 2010/10/27 06:00 [medline]
AID - S1438-4639(10)00044-1 [pii]
AID - 10.1016/j.ijheh.2010.04.003 [doi]
PST - ppublish
SO  - Int J Hyg Environ Health. 2010 Jul;213(4):302-7. doi:
      10.1016/j.ijheh.2010.04.003. Epub 2010 May 13.


PMID- 20470337
OWN - NLM
STAT- MEDLINE
DCOM- 20100830
LR  - 20220317
IS  - 1460-9592 (Electronic)
IS  - 1155-5645 (Linking)
VI  - 20
IP  - 4
DP  - 2010 Apr
TI  - Does the newer preparation of propofol, an emulsion of medium/long chain
      triglycerides cause less injection pain in children when premixed with
      lignocaine?
PG  - 338-42
LID - 10.1111/j.1460-9592.2010.03272.x [doi]
AB  - BACKGROUND: Injection pain during propofol administration can be particularly
      distressing in children. The newly available emulsion of propofol in medium and
      long chain triglycerides (LCT) is reported to cause less injection pain because
      of lower concentrations of free propofol. This study compared the incidence of
      injection pain during administration of propofol emulsion of LCT and propofol
      emulsion of medium and long chain triglycerides (MCT/LCT) both premixed with
      lignocaine in children. METHODS: This prospective, randomized, double blind study
      was conducted after obtaining institutional ethics committee approval, parental
      consent and included 84 children aged 5-15 years. Preoperatively, an intravenous 
      cannula was inserted in all children. four children were excluded. Those
      included, depending on the randomization, received 3 mg x kg(-1) of either
      propofol LCT or propofol MCT/LCT both premixed with lignocaine (0.1%). The
      incidence and intensity of injection pain was assessed. RESULTS: Pain on
      injection of propofol LCT with lignocaine was observed in 16/40 children (40%),
      five of these children complained of severe pain. In comparison, 14/40 (35%)
      children complained of pain following propofol MCT/LCT premixed with lignocaine
      (P = 0.644), the intensity being severe in two children (P = 0.698). CONCLUSIONS:
      Propofol MCT/LCT and propofol LCT premixed with lignocaine are both associated
      with pain on injection in children; the incidence and intensity of the injection 
      pain are similar.
FAU - Varghese, Elsa
AU  - Varghese E
AD  - Department of Anesthesiology, Kasturba Medical College & Hospital, Manipal,
      Karnataka, India.
FAU - Krishna, Handattu Mahabaleswara
AU  - Krishna HM
FAU - Nittala, Anuradha
AU  - Nittala A
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - France
TA  - Paediatr Anaesth
JT  - Paediatric anaesthesia
JID - 9206575
RN  - 0 (Anesthetics, Combined)
RN  - 0 (Anesthetics, Intravenous)
RN  - 0 (Anesthetics, Local)
RN  - 0 (Emulsions)
RN  - 0 (Triglycerides)
RN  - 98PI200987 (Lidocaine)
RN  - YI7VU623SF (Propofol)
SB  - IM
MH  - Adolescent
MH  - Anesthetics, Combined/*administration & dosage
MH  - Anesthetics, Intravenous/*adverse effects
MH  - Anesthetics, Local/*administration & dosage
MH  - Child
MH  - Child, Preschool
MH  - Double-Blind Method
MH  - Emulsions
MH  - Female
MH  - Humans
MH  - Injections, Intravenous/*adverse effects
MH  - Lidocaine/*administration & dosage
MH  - Male
MH  - Pain/etiology/*prevention & control
MH  - Pain Measurement/methods
MH  - Preoperative Care
MH  - Propofol/*administration & dosage/adverse effects
MH  - Prospective Studies
MH  - Severity of Illness Index
MH  - Triglycerides/administration & dosage
EDAT- 2010/05/18 06:00
MHDA- 2010/08/31 06:00
CRDT- 2010/05/18 06:00
PHST- 2010/05/18 06:00 [entrez]
PHST- 2010/05/18 06:00 [pubmed]
PHST- 2010/08/31 06:00 [medline]
AID - PAN3272 [pii]
AID - 10.1111/j.1460-9592.2010.03272.x [doi]
PST - ppublish
SO  - Paediatr Anaesth. 2010 Apr;20(4):338-42. doi: 10.1111/j.1460-9592.2010.03272.x.


PMID- 20469831
OWN - NLM
STAT- MEDLINE
DCOM- 20100601
LR  - 20100517
IS  - 0882-1577 (Print)
IS  - 0882-1577 (Linking)
VI  - 91
IP  - 3
DP  - 2010 May-Jun
TI  - A reader responds. "Thinking ethically about emergency contraception".
PG  - 64; author reply 65
FAU - Hilliard, Marie T
AU  - Hilliard MT
LA  - eng
PT  - Comment
PT  - Letter
PL  - United States
TA  - Health Prog
JT  - Health progress (Saint Louis, Mo.)
JID - 8500263
CON - Health Prog. 2010 Jan-Feb;91(1):62-7. PMID: 20108639
MH  - Catholicism
MH  - Contraception, Postcoital/*ethics
MH  - Nurses
MH  - United States
EDAT- 2010/05/18 06:00
MHDA- 2010/06/02 06:00
CRDT- 2010/05/18 06:00
PHST- 2010/05/18 06:00 [entrez]
PHST- 2010/05/18 06:00 [pubmed]
PHST- 2010/06/02 06:00 [medline]
PST - ppublish
SO  - Health Prog. 2010 May-Jun;91(3):64; author reply 65.


PMID- 20469829
OWN - NLM
STAT- MEDLINE
DCOM- 20100601
LR  - 20100517
IS  - 0882-1577 (Print)
IS  - 0882-1577 (Linking)
VI  - 91
IP  - 3
DP  - 2010 May-Jun
TI  - Strengthening the role of ethics in turbulent times.
PG  - 60-1
FAU - Hamel, Ron
AU  - Hamel R
AD  - Catholic Health Association, St. Louis, USA. rhamel@chausa.org
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Health Prog
JT  - Health progress (Saint Louis, Mo.)
JID - 8500263
MH  - Catholicism
MH  - Delivery of Health Care/*ethics
MH  - Economic Recession
MH  - Hospitals, Religious
MH  - United States
EDAT- 2010/05/18 06:00
MHDA- 2010/06/02 06:00
CRDT- 2010/05/18 06:00
PHST- 2010/05/18 06:00 [entrez]
PHST- 2010/05/18 06:00 [pubmed]
PHST- 2010/06/02 06:00 [medline]
PST - ppublish
SO  - Health Prog. 2010 May-Jun;91(3):60-1.


PMID- 20469655
OWN - NLM
STAT- MEDLINE
DCOM- 20100603
LR  - 20161021
IS  - 1183-5702 (Print)
IS  - 1183-5702 (Linking)
VI  - 25
IP  - 1
DP  - 2010 Spring
TI  - Beat Those Bugs! Implementing contact precautions in community dialysis units for
      closer-to-home care.
PG  - 9-16
AB  - "Beat Those Bugs!" was the call to action for the Providence Health Care Renal
      and Infection Prevention and Control programs to provide closer-to-home care in
      community dialysis units, for hemodialysis patients positive for the
      antibiotic-resistant organisms, Methicillin-Resistant Staphylococcus aureus and
      Vancomycin-Resistant Enterococcus. The initiative assessed barriers and
      facilitators to: implementing Contact Precautions; developing practice standards 
      for nurses and renal technicians to enact Contact Precautions care; providing
      staff and patient education essential to implementing these standards; and,
      securing environmental and equipment supports required for Contact Precautions
      care. Through the "Beat Those Bugs!" initiative, all six Providence Health Care
      Community Dialysis Units have the capacity to provide Standard/ Routine as well
      as Contact Precautions care enabling patients to receive closer-to-home care in
      their home communities regardless of their antibiotic-resistant microorganism
      status. Program evaluation (based on annual screening) demonstrates that the
      "Beat Those Bugs!" program is an effective model for safe, evidence-based and
      ethical care in the hemodialysis setting.
FAU - Curtin, Jim
AU  - Curtin J
AD  - Infection Prevention and Control (IPAC), Providence Health Care, Vancouver, BC
      V6Z 2K5. jcurtin@providencehealth.bc.ca
FAU - Dalziel, Carole
AU  - Dalziel C
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can J Infect Control
JT  - The Canadian journal of infection control : the official journal of the Community
      & Hospital Infection Control Association-Canada = Revue canadienne de prevention 
      des infections
JID - 9114581
RN  - 6Q205EH1VU (Vancomycin)
RN  - Q91FH1328A (Methicillin)
MH  - Aged
MH  - Evidence-Based Medicine/standards
MH  - Humans
MH  - Infection Control/*standards
MH  - Methicillin/pharmacology
MH  - Methicillin-Resistant Staphylococcus aureus/drug effects
MH  - Patient Care Team
MH  - Renal Dialysis/*standards
MH  - Staphylococcal Infections/prevention & control/transmission
MH  - Staphylococcus aureus/drug effects
MH  - Vancomycin/pharmacology
EDAT- 2010/05/18 06:00
MHDA- 2010/06/04 06:00
CRDT- 2010/05/18 06:00
PHST- 2010/05/18 06:00 [entrez]
PHST- 2010/05/18 06:00 [pubmed]
PHST- 2010/06/04 06:00 [medline]
PST - ppublish
SO  - Can J Infect Control. 2010 Spring;25(1):9-16.


PMID- 20467985
OWN - NLM
STAT- MEDLINE
DCOM- 20100716
LR  - 20191027
IS  - 1049-023X (Print)
IS  - 1049-023X (Linking)
VI  - 25
IP  - 2
DP  - 2010 Mar-Apr
TI  - Pandemic influenza triage in the clinical setting.
PG  - 99-104
AB  - INTRODUCTION: There has been much federal and local health planning for an
      influenza pandemic in the United States, but little is known about the ability of
      the clinical community to deal quickly and effectively with a potentially
      overwhelming surge of pandemic influenza patients. PROBLEM: The attitudes and
      expectations of emergency physicians, emergency nurses, hospital nursing
      supervisors, hospital administrators, and infection control personnel concerning 
      clinical care in a pandemic were assessed. METHODS: Key informant structured
      interviews of 46 respondents from 34 randomly selected emergency receiving
      hospitals in Los Angeles County were conducted using an Institutional Review
      Board-approved protocol. The interview asked about supplies/resources, triage,
      quality of care, and decision-making. At the conclusion of each interview, the
      informant was asked to provide the contact information for at least two others
      within their respective professional group. Interviews were transcribed and coded
      for key themes using qualitative analytical software. RESULTS: There was little
      salience that an influx of variably ill patients with influenza would force
      stratified healthcare decision-making. There also was a general lack of
      preparation to address the ethics and practices of triaging patients in the
      clinical setting of a pandemic. CONCLUSIONS: Guidelines must be developed in
      concert with public health, medical society, and legislative authorities to help 
      clinicians define, adopt, and communicate to the public those practice standards 
      that will be followed in a mass population, infectious disease emergency.
FAU - Rottman, Steven J
AU  - Rottman SJ
AD  - University of California Los Angeles Center for Public Health and Disasters, Los 
      Angeles, California 90024, USA. rottman@ucla.edu
FAU - Shoaf, Kimberley I
AU  - Shoaf KI
FAU - Schlesinger, Jennifer
AU  - Schlesinger J
FAU - Klein Selski, Eva
AU  - Klein Selski E
FAU - Perman, Joey
AU  - Perman J
FAU - Lamb, Kerry
AU  - Lamb K
FAU - Cheng, Janet
AU  - Cheng J
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Multicenter Study
PL  - United States
TA  - Prehosp Disaster Med
JT  - Prehospital and disaster medicine
JID - 8918173
CIN - Prehosp Disaster Med. 2010 Mar-Apr;25(2):105-6. PMID: 20467986
MH  - *Attitude of Health Personnel
MH  - *Disaster Planning
MH  - *Disease Outbreaks
MH  - Humans
MH  - Influenza, Human/*epidemiology
MH  - Los Angeles/epidemiology
MH  - Qualitative Research
MH  - Quality of Health Care/ethics
MH  - Triage/*ethics/*organization & administration
EDAT- 2010/05/15 06:00
MHDA- 2010/07/17 06:00
CRDT- 2010/05/15 06:00
PHST- 2010/05/15 06:00 [entrez]
PHST- 2010/05/15 06:00 [pubmed]
PHST- 2010/07/17 06:00 [medline]
AID - 10.1017/s1049023x00007792 [doi]
PST - ppublish
SO  - Prehosp Disaster Med. 2010 Mar-Apr;25(2):99-104. doi: 10.1017/s1049023x00007792.


PMID- 20467842
OWN - NLM
STAT- MEDLINE
DCOM- 20120209
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 17
IP  - 2
DP  - 2011 Jun
TI  - Broadening ethics teaching in engineering: beyond the individualistic approach.
PG  - 217-32
LID - 10.1007/s11948-010-9205-7 [doi]
AB  - There is a widespread approach to the teaching of ethics to engineering students 
      in which the exclusive focus is on engineers as individual agents and the broader
      context in which they do their work is ignored. Although this approach has
      frequently been criticised in the literature, it persists on a wide scale, as can
      be inferred from accounts in the educational literature and from the contents of 
      widely used textbooks in engineering ethics. In this contribution we intend to:
      (1) Restate why the individualistic approach to the teaching of ethics to
      engineering students is inadequate in view of preparing them for ethical,
      professional and social responsibility; (2) Examine the existing literature
      regarding the possible contribution of Science, Technology and Society (STS)
      scholarship in addressing the inadequacies of the individualistic approach; and
      (3) Assess this possible contribution of STS in order to realise desired learning
      outcomes regarding the preparation of students for ethical and social
      responsibility.
FAU - Conlon, Eddie
AU  - Conlon E
AD  - Faculty of Engineering, Dublin Institute of Technology, Dublin, Ireland.
      Edward.conlon@dit.ie
FAU - Zandvoort, Henk
AU  - Zandvoort H
LA  - eng
PT  - Journal Article
DEP - 20100514
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Engineering/education/*ethics
MH  - Ethics, Professional/*education
MH  - Humans
MH  - *Social Responsibility
MH  - Teaching/*methods
EDAT- 2010/05/15 06:00
MHDA- 2012/02/10 06:00
CRDT- 2010/05/15 06:00
PHST- 2009/12/11 00:00 [received]
PHST- 2010/04/26 00:00 [accepted]
PHST- 2010/05/15 06:00 [entrez]
PHST- 2010/05/15 06:00 [pubmed]
PHST- 2012/02/10 06:00 [medline]
AID - 10.1007/s11948-010-9205-7 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2011 Jun;17(2):217-32. doi: 10.1007/s11948-010-9205-7. Epub 2010 
      May 14.


PMID- 20467767
OWN - NLM
STAT- MEDLINE
DCOM- 20120105
LR  - 20211020
IS  - 1248-9204 (Electronic)
IS  - 1248-9204 (Linking)
VI  - 15
IP  - 4
DP  - 2011 Aug
TI  - Single incision laparoscopic totally extraperitoneal inguinal hernia repair.
PG  - 451-3
LID - 10.1007/s10029-010-0674-z [doi]
AB  - AIMS: Various single incision laparoscopic surgeries (SILS) and natural orifice
      transluminal endoscopic surgeries (NOTES) have been reported recently. Herein we 
      performed SILS for totally extraperitoneal inguinal hernia repair (TEP) on three 
      cases. CASES: Three males of 72, 49, and 73 years old with the diagnoses of
      bilateral primary inguinal hernia underwent single incision TEP. The operative
      steps of single incision TEP are very similar to those of a traditional
      laparoscopic TEP. The difference between them is a 2 cm infraumbilical incision
      for the placement of three (5 mm) trocars in single incision TEP. We preferred to
      use a 30 degrees 5 mm laparoscope with some routine laparoscopic instruments
      during the surgical procedure. All the hernia defects were repaired with VyproII 
      of 15 x 10 cm (Ethicon, NJ, USA). The operations took 32, 26, and 65 min,
      respectively, with no obvious inconvenience. RESULTS: All three patients were
      discharged on the second postoperative day uneventfully. The postoperative
      follow-up showed no recurrence in the three patients up to now. CONCLUSION: The
      single incision TEP using an access port device is safe and feasible. Meanwhile
      SILS may reduce medical costs and complication rates through practice and
      improvement of SILS instruments.
FAU - He, Kai
AU  - He K
AD  - Department of General Surgery, Huashan Hospital Hernia Center, Shanghai Medical
      College, Fudan University, Shanghai, China.
FAU - Chen, Hao
AU  - Chen H
FAU - Ding, Rui
AU  - Ding R
FAU - Hua, Rong
AU  - Hua R
FAU - Yao, Qiyuan
AU  - Yao Q
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20100514
PL  - France
TA  - Hernia
JT  - Hernia : the journal of hernias and abdominal wall surgery
JID - 9715168
SB  - IM
MH  - Aged
MH  - Hernia, Inguinal/*surgery
MH  - Herniorrhaphy/instrumentation/*methods
MH  - Humans
MH  - Laparoscopy/instrumentation/*methods
MH  - Male
MH  - Middle Aged
MH  - Pain, Postoperative
MH  - Time Factors
EDAT- 2010/05/15 06:00
MHDA- 2012/01/06 06:00
CRDT- 2010/05/15 06:00
PHST- 2010/02/22 00:00 [received]
PHST- 2010/04/23 00:00 [accepted]
PHST- 2010/05/15 06:00 [entrez]
PHST- 2010/05/15 06:00 [pubmed]
PHST- 2012/01/06 06:00 [medline]
AID - 10.1007/s10029-010-0674-z [doi]
PST - ppublish
SO  - Hernia. 2011 Aug;15(4):451-3. doi: 10.1007/s10029-010-0674-z. Epub 2010 May 14.


PMID- 20467278
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20151119
IS  - 1932-8095 (Electronic)
IS  - 1932-8087 (Linking)
VI  - 15
IP  - 3
DP  - 2010 May-Jun
TI  - Case management across the life continuum: ethical obligations versus best
      practice.
PG  - 153-6
LID - 10.1097/NCM.0b013e3181e12adb [doi]
FAU - Fink-Samnick, Ellen
AU  - Fink-Samnick E
AD  - Commission for Case Manager Certification (CCMC), USA. epflcswccm@aol.com
FAU - Muller, Lynn S
AU  - Muller LS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Prof Case Manag
JT  - Professional case management
JID - 101291585
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aging
MH  - Case Management/*ethics
MH  - Child
MH  - Child, Preschool
MH  - Continuity of Patient Care/*ethics
MH  - *Ethics, Professional
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Middle Aged
MH  - Practice Patterns, Physicians'/*ethics
MH  - *Social Responsibility
MH  - Young Adult
EDAT- 2010/05/15 06:00
MHDA- 2010/09/15 06:00
CRDT- 2010/05/15 06:00
PHST- 2010/05/15 06:00 [entrez]
PHST- 2010/05/15 06:00 [pubmed]
PHST- 2010/09/15 06:00 [medline]
AID - 10.1097/NCM.0b013e3181e12adb [doi]
AID - 01269241-201005000-00008 [pii]
PST - ppublish
SO  - Prof Case Manag. 2010 May-Jun;15(3):153-6. doi: 10.1097/NCM.0b013e3181e12adb.


PMID- 20467272
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20151119
IS  - 1932-8095 (Electronic)
IS  - 1932-8087 (Linking)
VI  - 15
IP  - 3
DP  - 2010 May-Jun
TI  - Grounding transdisciplinary practice in ethics.
PG  - 121-3
LID - 10.1097/NCM.0b013e3181e12aa9 [doi]
FAU - Fink-Samnick, Ellen
AU  - Fink-Samnick E
AD  - Commission for Case Manager Certification, USA. epflcswccm@aol.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Prof Case Manag
JT  - Professional case management
JID - 101291585
MH  - Case Management
MH  - *Ethics, Professional
MH  - Humans
MH  - *Interdisciplinary Communication
MH  - Practice Patterns, Physicians'/*ethics
EDAT- 2010/05/15 06:00
MHDA- 2010/09/15 06:00
CRDT- 2010/05/15 06:00
PHST- 2010/05/15 06:00 [entrez]
PHST- 2010/05/15 06:00 [pubmed]
PHST- 2010/09/15 06:00 [medline]
AID - 10.1097/NCM.0b013e3181e12aa9 [doi]
AID - 01269241-201005000-00002 [pii]
PST - ppublish
SO  - Prof Case Manag. 2010 May-Jun;15(3):121-3. doi: 10.1097/NCM.0b013e3181e12aa9.


PMID- 20466907
OWN - NLM
STAT- MEDLINE
DCOM- 20100527
LR  - 20211203
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Linking)
VI  - 328
IP  - 5980
DP  - 2010 May 14
TI  - Research ethics. Beyond access vs. protection in trials of innovative therapies.
PG  - 829-30
LID - 10.1126/science.1189369 [doi]
FAU - London, Alex John
AU  - London AJ
AD  - Department of Philosophy, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
FAU - Kimmelman, Jonathan
AU  - Kimmelman J
FAU - Emborg, Marina Elena
AU  - Emborg ME
LA  - eng
GR  - P51 RR000167/RR/NCRR NIH HHS/United States
GR  - NNF 80045/CAPMC/ CIHR/Canada
GR  - P51RR000167/RR/NCRR NIH HHS/United States
GR  - EOG 102824/CAPMC/ CIHR/Canada
GR  - 102823-1/CAPMC/ CIHR/Canada
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
SB  - IM
MH  - Biomedical Research/ethics/standards
MH  - Clinical Trials as Topic/*ethics/*standards
MH  - Ethics Committees, Research
MH  - Ethics, Research
MH  - Human Experimentation
MH  - Humans
MH  - Peer Review, Research
MH  - Translational Research, Biomedical/*ethics/*standards
PMC - PMC4516403
MID - CAMS4899
OID - NLM: CAMS4899
EDAT- 2010/05/15 06:00
MHDA- 2010/05/28 06:00
CRDT- 2010/05/15 06:00
PHST- 2010/05/15 06:00 [entrez]
PHST- 2010/05/15 06:00 [pubmed]
PHST- 2010/05/28 06:00 [medline]
AID - 328/5980/829 [pii]
AID - 10.1126/science.1189369 [doi]
PST - ppublish
SO  - Science. 2010 May 14;328(5980):829-30. doi: 10.1126/science.1189369.


PMID- 20466537
OWN - NLM
STAT- MEDLINE
DCOM- 20101227
LR  - 20181201
IS  - 1879-0852 (Electronic)
IS  - 0959-8049 (Linking)
VI  - 46
IP  - 12
DP  - 2010 Aug
TI  - Impact of information about risks and benefits of cancer screening on intended
      participation.
PG  - 2267-74
LID - 10.1016/j.ejca.2010.04.011 [doi]
AB  - BACKGROUND: Providing comprehensive information about the risks and benefits of
      cancer screening is ethically necessary, but information about risks may decrease
      participation. This study explored the impact of information on intended
      participation using a randomised factorial design. METHODS: We conducted a mail
      survey of 2333 adults living in Geneva, Switzerland. Each participant was given
      one randomly chosen version of a scenario that described a hypothetical cancer
      screening test, and was asked whether he or she would accept to undergo
      screening. The versions varied in terms of the amount of information about risks 
      and benefits. RESULTS: Respondents who received information about risks
      associated with screening were more likely to refuse participation (odds ratio
      2.6 (95% confidence interval (CI) 2.0-3.5)) than those who received minimal
      information. In contrast, information about benefits had no impact on intended
      participation (odds ratio 1.0 (95% CI 0.8-1.2)). The impact of information about 
      risks was significantly stronger in women than in men, in respondents who were in
      poorer health, who have had a doctor visit in the past 6months, those who have
      had a cancer screening test in the past 3years, and those who reported a high
      desire for autonomy in medical decisions. CONCLUSIONS: Informing potential
      participants about the risks of screening may reduce participation rates.
      Enhanced information about the benefits of screening does not counterbalance this
      effect.
CI  - Copyright 2010 Elsevier Ltd. All rights reserved.
FAU - Perneger, Thomas V
AU  - Perneger TV
AD  - Division of Clinical Epidemiology, University Hospitals of Geneva, Switzerland;
      Quality of Care Service, University Hospitals of Geneva, Switzerland.
      thomas.perneger@hcuge.ch
FAU - Cullati, Stephane
AU  - Cullati S
FAU - Schiesari, Laura
AU  - Schiesari L
FAU - Charvet-Berard, Agathe
AU  - Charvet-Berard A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100511
PL  - England
TA  - Eur J Cancer
JT  - European journal of cancer (Oxford, England : 1990)
JID - 9005373
SB  - IM
MH  - Adult
MH  - Early Detection of Cancer/*statistics & numerical data
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/*prevention & control
MH  - Patient Acceptance of Health Care/*psychology
MH  - Patient Compliance/psychology
MH  - *Patient Education as Topic
MH  - Risk Assessment
MH  - Surveys and Questionnaires
MH  - Switzerland
EDAT- 2010/05/15 06:00
MHDA- 2010/12/28 06:00
CRDT- 2010/05/15 06:00
PHST- 2010/01/04 00:00 [received]
PHST- 2010/04/07 00:00 [revised]
PHST- 2010/04/09 00:00 [accepted]
PHST- 2010/05/15 06:00 [entrez]
PHST- 2010/05/15 06:00 [pubmed]
PHST- 2010/12/28 06:00 [medline]
AID - S0959-8049(10)00314-X [pii]
AID - 10.1016/j.ejca.2010.04.011 [doi]
PST - ppublish
SO  - Eur J Cancer. 2010 Aug;46(12):2267-74. doi: 10.1016/j.ejca.2010.04.011. Epub 2010
      May 11.


PMID- 20466293
OWN - NLM
STAT- MEDLINE
DCOM- 20100818
LR  - 20131121
IS  - 1875-6263 (Electronic)
IS  - 1028-4559 (Linking)
VI  - 49
IP  - 1
DP  - 2010 Mar
TI  - Informed consent for antenatal serum screening for Down syndrome.
PG  - 50-6
LID - 10.1016/S1028-4559(10)60009-5 [doi]
AB  - OBJECTIVE: Respect for patients' autonomy is a principle issue in medical ethics.
      Patients' understanding of antenatal serum screening for Down syndrome upon
      informed consent has barely been assessed. Our objective was to evaluate pregnant
      women's perceived level of understanding of this serum screening. MATERIALS AND
      METHODS: Pregnant women between the 15(th) and 21(st) gestational week were
      randomized into control and experimental groups, and were asked to complete a
      questionnaire before and after genetic counselling provided by researchers. The
      primary endpoints were the perceived level of understanding of serum screening
      for Down syndrome and the autonomy of the decision making for this serum
      screening. The secondary endpoints were the anxiety and depression levels of
      these women. RESULTS: Participants in the experimental group (n = 96) had a
      significantly higher perceived level of understanding of antenatal serum
      screening for Down syndrome than participants in the control group (n = 97).
      There were significantly more respondents in the experimental group making the
      decision themselves to undergo serum screening than women in the control group.
      Anxiety and depression levels were not significantly different between the women 
      in the two groups. CONCLUSION: Pregnant women should be offered more information 
      to allow them to make an informed decision before they undergo antenatal serum
      screening for Down syndrome. Comprehensive genetic counseling improved pregnant
      women's autonomy in deciding whether to participate in serum screening. Health
      service providers should make effort to fulfill the ethical requirements of
      informed consent.
FAU - Hwa, Hsiao-Lin
AU  - Hwa HL
AD  - Department of Obstetrics and Gynecology, National Taiwan University Hospital and 
      College of Medicine, National Taiwan University Hospital, Taipei, Taiwan.
FAU - Huang, Lian-Hua
AU  - Huang LH
FAU - Hsieh, Fon-Jou
AU  - Hsieh FJ
FAU - Chow, Song-Nan
AU  - Chow SN
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - China (Republic : 1949- )
TA  - Taiwan J Obstet Gynecol
JT  - Taiwanese journal of obstetrics & gynecology
JID - 101213819
RN  - 0 (Chorionic Gonadotropin)
RN  - 0 (alpha-Fetoproteins)
RN  - FB33469R8E (Estriol)
SB  - IM
MH  - Adult
MH  - Anxiety/epidemiology
MH  - Chorionic Gonadotropin/blood
MH  - Depression/epidemiology
MH  - Down Syndrome/*diagnosis
MH  - Estriol/blood
MH  - Female
MH  - Genetic Counseling
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - *Informed Consent
MH  - Maternal Age
MH  - Personal Autonomy
MH  - Pregnancy
MH  - *Prenatal Diagnosis
MH  - alpha-Fetoproteins/analysis
EDAT- 2010/05/15 06:00
MHDA- 2010/08/19 06:00
CRDT- 2010/05/15 06:00
PHST- 2008/08/01 00:00 [accepted]
PHST- 2010/05/15 06:00 [entrez]
PHST- 2010/05/15 06:00 [pubmed]
PHST- 2010/08/19 06:00 [medline]
AID - S1028-4559(10)60009-5 [pii]
AID - 10.1016/S1028-4559(10)60009-5 [doi]
PST - ppublish
SO  - Taiwan J Obstet Gynecol. 2010 Mar;49(1):50-6. doi: 10.1016/S1028-4559(10)60009-5.


PMID- 20466090
OWN - NLM
STAT- MEDLINE
DCOM- 20100621
LR  - 20220318
IS  - 1537-6605 (Electronic)
IS  - 0002-9297 (Linking)
VI  - 86
IP  - 5
DP  - 2010 May 14
TI  - Inferring genetic ancestry: opportunities, challenges, and implications.
PG  - 661-73
LID - 10.1016/j.ajhg.2010.03.011 [doi]
AB  - Increasing public interest in direct-to-consumer (DTC) genetic ancestry testing
      has been accompanied by growing concern about issues ranging from the personal
      and societal implications of the testing to the scientific validity of ancestry
      inference. The very concept of "ancestry" is subject to misunderstanding in both 
      the general and scientific communities. What do we mean by ancestry? How exactly 
      is ancestry measured? How far back can such ancestry be defined and by which
      genetic tools? How do we validate inferences about ancestry in genetic research? 
      What are the data that demonstrate our ability to do this correctly? What can we 
      say and what can we not say from our research findings and the test results that 
      we generate? This white paper from the American Society of Human Genetics (ASHG) 
      Ancestry and Ancestry Testing Task Force builds upon the 2008 ASHG Ancestry
      Testing Summary Statement in providing a more in-depth analysis of key scientific
      and non-scientific aspects of genetic ancestry inference in academia and
      industry. It culminates with recommendations for advancing the current debate and
      facilitating the development of scientifically based, ethically sound, and
      socially attentive guidelines concerning the use of these continually evolving
      technologies.
CI  - Copyright (c) 2010 The American Society of Human Genetics. Published by Elsevier 
      Inc. All rights reserved.
FAU - Royal, Charmaine D
AU  - Royal CD
AD  - Institute for Genome Sciences & Policy, Duke University, Durham, NC 27708, USA.
      charmaine.royal@duke.edu
FAU - Novembre, John
AU  - Novembre J
FAU - Fullerton, Stephanie M
AU  - Fullerton SM
FAU - Goldstein, David B
AU  - Goldstein DB
FAU - Long, Jeffrey C
AU  - Long JC
FAU - Bamshad, Michael J
AU  - Bamshad MJ
FAU - Clark, Andrew G
AU  - Clark AG
LA  - eng
GR  - R01 HL072904/HL/NHLBI NIH HHS/United States
GR  - R01 HL072810-06/HL/NHLBI NIH HHS/United States
GR  - R01 HL072810-05A1/HL/NHLBI NIH HHS/United States
GR  - R01 HL072810-03/HL/NHLBI NIH HHS/United States
GR  - R01 HL072810-07/HL/NHLBI NIH HHS/United States
GR  - R01 HG003229/HG/NHGRI NIH HHS/United States
GR  - R01 HL072904-08/HL/NHLBI NIH HHS/United States
GR  - R01 HL072810-09/HL/NHLBI NIH HHS/United States
GR  - R01 HL072810-01/HL/NHLBI NIH HHS/United States
GR  - R01 HG003229-05/HG/NHGRI NIH HHS/United States
GR  - R01 HL072810-08/HL/NHLBI NIH HHS/United States
GR  - R01 HL072810-02/HL/NHLBI NIH HHS/United States
GR  - R01 HL072810-04/HL/NHLBI NIH HHS/United States
GR  - R01 HL072810/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Am J Hum Genet
JT  - American journal of human genetics
JID - 0370475
SB  - IM
MH  - *Genes
MH  - Genetic Research/*ethics
MH  - Genetic Testing/standards
MH  - Humans
MH  - Patients/*psychology
MH  - Whites/*genetics
PMC - PMC2869013
EDAT- 2010/05/15 06:00
MHDA- 2010/06/22 06:00
CRDT- 2010/05/15 06:00
PHST- 2009/12/08 00:00 [received]
PHST- 2010/02/22 00:00 [revised]
PHST- 2010/03/10 00:00 [accepted]
PHST- 2010/05/15 06:00 [entrez]
PHST- 2010/05/15 06:00 [pubmed]
PHST- 2010/06/22 06:00 [medline]
AID - S0002-9297(10)00155-2 [pii]
AID - 10.1016/j.ajhg.2010.03.011 [doi]
PST - ppublish
SO  - Am J Hum Genet. 2010 May 14;86(5):661-73. doi: 10.1016/j.ajhg.2010.03.011.


PMID- 20465819
OWN - NLM
STAT- MEDLINE
DCOM- 20101102
LR  - 20220309
IS  - 1472-6963 (Electronic)
IS  - 1472-6963 (Linking)
VI  - 10
DP  - 2010 May 13
TI  - One stop or full stop? The continuing challenges for researchers despite the new 
      streamlined NHS research governance process.
PG  - 124
LID - 10.1186/1472-6963-10-124 [doi]
AB  - BACKGROUND: Obtaining the necessary approvals and permission for clinical
      research requires successful negotiation of the ethical and R&D layers of the
      NHS. Differences in structure and governance frameworks feature between the
      constituent nations of the UK (England, Scotland, Wales and Northern Ireland),
      which adds complexity to cross-national studies. Difficulties in carrying out
      research in the NHS in the UK due to bureaucratic and time-consuming governance
      processes have led to the development of a new system of application and
      co-ordination from 2009. This paper illustrates how this new system fails to be
      consistent and streamlined and is unlikely to become so unless changes are made
      to the implementation and management of the governance processes. METHODS: We
      present a case study of the research governance process at the survey stage of an
      investigation into the use, preferences and need for information by people making
      choices or decisions about health care. The method involved home-based,
      face-to-face interviewing in a questionnaire survey in relation to decisions
      about lymphoma treatment, Down's syndrome screening in pregnancy, and caring for 
      people with dementia. RESULTS: Our experience of the ethics stage was very
      positive, noting an efficient process of application and a speedy decision, both 
      in relation to the initial application and to subsequent substantial amendments. 
      By contrast, the R&D stages were very slow, most with unexplained delays, but
      some offering contradictory advice and exhibiting a lack of clear guidance and
      training for NHS staff. The R&D arrangements in Scotland were far quicker and
      more likely to be successful than in England. Overall, the delays were so severe 
      that substantial parts of the research could not be delivered as planned within
      the funding timescale. CONCLUSIONS: If high-quality research in the NHS,
      particularly in England, is to be delivered in a timely and cost-effective way,
      R&D processes for gaining research governance approval need improvement.
      Attention is needed in process implementation and management, particularly in
      relation to staff training, as well as clarity in guidance and communication
      within and between organisations.
FAU - Thompson, Andrew G H
AU  - Thompson AG
AD  - Politics and International Relations, School of Social and Political Science,
      University of Edinburgh, Chrystal Macmillan Building, 15A George Square,
      Edinburgh EH8 9LD, UK.
FAU - France, Emma F
AU  - France EF
LA  - eng
GR  - Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100513
PL  - England
TA  - BMC Health Serv Res
JT  - BMC health services research
JID - 101088677
SB  - IM
MH  - Adult
MH  - *Attitude to Health
MH  - Clinical Governance/*organization & administration
MH  - Efficiency, Organizational
MH  - England
MH  - Female
MH  - Health Services Needs and Demand
MH  - Health Services Research/*organization & administration
MH  - Humans
MH  - Interviews as Topic
MH  - Pregnancy
MH  - Research Personnel
MH  - Scotland
MH  - State Medicine/*organization & administration
MH  - Surveys and Questionnaires
PMC - PMC2882919
EDAT- 2010/05/15 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/05/15 06:00
PHST- 2009/12/07 00:00 [received]
PHST- 2010/05/13 00:00 [accepted]
PHST- 2010/05/15 06:00 [entrez]
PHST- 2010/05/15 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - 1472-6963-10-124 [pii]
AID - 10.1186/1472-6963-10-124 [doi]
PST - epublish
SO  - BMC Health Serv Res. 2010 May 13;10:124. doi: 10.1186/1472-6963-10-124.


PMID- 20465799
OWN - NLM
STAT- MEDLINE
DCOM- 20100726
LR  - 20211020
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 11
DP  - 2010 May 13
TI  - Evaluation of exercise on individuals with dementia and their carers: a
      randomised controlled trial.
PG  - 53
LID - 10.1186/1745-6215-11-53 [doi]
AB  - BACKGROUND: Almost all of the 820,000 people in the UK with dementia will
      experience Behavioural and Psychological Symptoms of Dementia (BPSD). However,
      research has traditionally focused on treating cognitive symptoms, thus
      neglecting core clinical symptoms that often have a more profound impact on
      living with dementia. Recent evidence (Kales et al, 2007; Ballard et al, 2009)
      indicates that the popular approach to managing BPSD - prescription of
      anti-psychotic medication - can increase mortality and the risk of stroke in
      people with dementia as well as impair quality of life and accelerate cognitive
      decline. Consequently, there is a need to evaluate the impact that
      non-pharmacological interventions have on BPSD; we believe physical exercise is a
      particularly promising approach. METHODS/DESIGN: We will carry out a pragmatic,
      randomised, single-blind controlled trial to evaluate the effectiveness of
      exercise (planned walking) on the behavioural and psychological symptoms of
      individuals with dementia. We aim to recruit 146 people with dementia and their
      carers to be randomized into two groups; one will be trained in a structured,
      tailored walking programme, while the other will continue with treatment as
      usual. The primary outcome (BPSD) will be assessed with the Neuropsychiatric
      Inventory (NPI) along with relevant secondary outcomes at baseline, 6 and 12
      weeks. DISCUSSION: Designing this study has been challenging both ethically and
      methodologically. In particular to design an intervention that is simple,
      measurable, safe, non-invasive and enjoyable has been testing and has required a 
      lot of thought. Throughout the design, we have attempted to balance
      methodological rigour with study feasibility. We will discuss the challenges that
      were faced and overcome in this paper. TRIAL REGISTRATION: ISRCTN01423159.
FAU - Cerga-Pashoja, Arlinda
AU  - Cerga-Pashoja A
AD  - Central & North West London NHS Foundation Trust, Greater London House, Hampstead
      Rd, London, NW1 7QY, UK.
FAU - Lowery, David
AU  - Lowery D
FAU - Bhattacharya, Rahul
AU  - Bhattacharya R
FAU - Griffin, Mark
AU  - Griffin M
FAU - Iliffe, Steve
AU  - Iliffe S
FAU - Lee, James
AU  - Lee J
FAU - Leonard, Claire
AU  - Leonard C
FAU - Ricketts, Sue
AU  - Ricketts S
FAU - Strother, Lyn
AU  - Strother L
FAU - Waters, Fiona
AU  - Waters F
FAU - Ritchie, Craig W
AU  - Ritchie CW
FAU - Warner, James
AU  - Warner J
LA  - eng
SI  - ISRCTN/ISRCTN01423159
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20100513
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Caregivers/*psychology
MH  - Dementia/*psychology/*therapy
MH  - *Exercise Therapy
MH  - Humans
MH  - Neuropsychological Tests
MH  - *Quality of Life
MH  - Research Design
MH  - Single-Blind Method
MH  - *Walking
PMC - PMC2881915
EDAT- 2010/05/15 06:00
MHDA- 2010/07/27 06:00
CRDT- 2010/05/15 06:00
PHST- 2009/12/11 00:00 [received]
PHST- 2010/05/13 00:00 [accepted]
PHST- 2010/05/15 06:00 [entrez]
PHST- 2010/05/15 06:00 [pubmed]
PHST- 2010/07/27 06:00 [medline]
AID - 1745-6215-11-53 [pii]
AID - 10.1186/1745-6215-11-53 [doi]
PST - epublish
SO  - Trials. 2010 May 13;11:53. doi: 10.1186/1745-6215-11-53.


PMID- 20465769
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20161125
IS  - 1365-2850 (Electronic)
IS  - 1351-0126 (Linking)
VI  - 17
IP  - 3
DP  - 2010 Apr
TI  - Ethnography and the ethics of undertaking research in different mental healthcare
      settings.
PG  - 210-5
LID - 10.1111/j.1365-2850.2009.01493.x [doi]
AB  - This paper draws on our experiences of seeking research ethics and management
      approval for a 1-year ethnographic research study in three mental health
      settings. We argue that the increased bureaucratization of research governance in
      the UK is paternalistic and unfit for qualitative, non-interventionist study
      designs. The classification of all mental health services users as 'vulnerable'
      is also disempowering and contrary to government calls to increase user
      involvement in research processes. We relate our difficulties in accessing
      National Health Service sites to undertake our study despite endorsement by
      senior managers. The current research ethics system reinforces the gatekeeping
      role of front-line National Health Service staff but this may work to bias
      samples in favour of 'amenable' service users and exclude others from having
      their views and experiences represented in studies over the long-term.
FAU - Allbutt, H
AU  - Allbutt H
AD  - NHS Education for Scotland, Edinburgh EH12 5HD, UK. helen.allbutt@nes.scot.nhs.uk
FAU - Masters, H
AU  - Masters H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Psychiatr Ment Health Nurs
JT  - Journal of psychiatric and mental health nursing
JID - 9439514
MH  - Anthropology, Cultural/*ethics/*methods
MH  - *Ethics, Professional
MH  - Health Services Accessibility
MH  - Humans
MH  - Mental Health Services/*organization & administration
MH  - Professional Role
MH  - Referral and Consultation
MH  - Research/*standards
MH  - United Kingdom
EDAT- 2010/05/15 06:00
MHDA- 2010/09/15 06:00
CRDT- 2010/05/15 06:00
PHST- 2010/05/15 06:00 [entrez]
PHST- 2010/05/15 06:00 [pubmed]
PHST- 2010/09/15 06:00 [medline]
AID - JPM1493 [pii]
AID - 10.1111/j.1365-2850.2009.01493.x [doi]
PST - ppublish
SO  - J Psychiatr Ment Health Nurs. 2010 Apr;17(3):210-5. doi:
      10.1111/j.1365-2850.2009.01493.x.


PMID- 20465761
OWN - NLM
STAT- MEDLINE
DCOM- 20100930
LR  - 20211203
IS  - 1365-2850 (Electronic)
IS  - 1351-0126 (Linking)
VI  - 17
IP  - 2
DP  - 2010 Mar
TI  - Mental health care and resistance to fascism.
PG  - 152-61
LID - 10.1111/j.1365-2850.2009.01489.x [doi]
AB  - Mental health nurses have a critical stake in resisting the right-wing ideology
      of British fascism. Particularly concerning is the contemporary effort of the
      British National Party (BNP) to gain credibility and electoral support by the
      strategic re-packaging of a racist and divisive political manifesto. Evidence
      that some public sector workers are affiliated with the BNP has relevance for
      nursing at a series of levels, not least the incompatibility of party membership 
      with a requirement of the Professional Code to avoid discrimination. Progressive 
      advances, though, need to account for deep rooted institutionalized racism in the
      discourse and practice of healthcare services. The anomalous treatment of black
      people within mental health services, alongside racial abuse experienced by
      ethnic minority staff, is discussed in relation to the concept of race as a
      powerful social category and construction. The murder of the mentally ill and
      learning disabled in Nazi Germany, as an adjunct of racial genocide, is presented
      as an extreme example where professional ethics was undermined by dominant
      political ideology. Finally, the complicity of medical and nursing staff in the
      state sanctioned, bureaucratic, killing that characterized the Holocaust is
      revisited in the context of ethical repositioning for contemporary practice and
      praxis.
FAU - McKeown, M
AU  - McKeown M
AD  - School of Nursing & Caring Sciences, University of Central Lancashire,
      Lancashire, UK. mmckeown@uclan.ac.uk
FAU - Mercer, D
AU  - Mercer D
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Psychiatr Ment Health Nurs
JT  - Journal of psychiatric and mental health nursing
JID - 9439514
MH  - *Authoritarianism
MH  - Blacks/*psychology
MH  - *Ethics, Nursing
MH  - Humans
MH  - Mental Disorders/*nursing
MH  - National Socialism
MH  - *Political Systems
MH  - *Prejudice
MH  - *State Medicine
MH  - United Kingdom
MH  - Whites/*psychology
EDAT- 2010/05/15 06:00
MHDA- 2010/10/01 06:00
CRDT- 2010/05/15 06:00
PHST- 2010/05/15 06:00 [entrez]
PHST- 2010/05/15 06:00 [pubmed]
PHST- 2010/10/01 06:00 [medline]
AID - JPM1489 [pii]
AID - 10.1111/j.1365-2850.2009.01489.x [doi]
PST - ppublish
SO  - J Psychiatr Ment Health Nurs. 2010 Mar;17(2):152-61. doi:
      10.1111/j.1365-2850.2009.01489.x.


PMID- 20465755
OWN - NLM
STAT- MEDLINE
DCOM- 20100930
LR  - 20191210
IS  - 1365-2850 (Electronic)
IS  - 1351-0126 (Linking)
VI  - 17
IP  - 2
DP  - 2010 Mar
TI  - Autoethnographic ethics and rewriting the fragmented self.
PG  - 111-6
LID - 10.1111/j.1365-2850.2009.01478.x [doi]
AB  - The paper begins with a summary of severe mental health difficulties I had in
      recent years. The narrative then turns to the crisis of representation in the
      social sciences which gave rise to autoethnographic ethics. Autoethnographic
      writing is compared and contrasted with realist writing, the former being seen to
      be accorded with several advantages when 'writing the self'. It is argued that
      culture flows through self and vice versa, and that this is captured well in
      autoethnographic work. The various forms of ethics are brought to light in
      relation to my experiences of state acute mental health care.
FAU - Grant, A
AU  - Grant A
AD  - School of Nursing and Midwifery, Faculty of Health and Social Sciences,
      University of Brighton, Brighton BN1 9PH, UK. info@fusionpsychotherapy.com
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Psychiatr Ment Health Nurs
JT  - Journal of psychiatric and mental health nursing
JID - 9439514
MH  - Anthropology, Cultural/*ethics
MH  - Autobiographies as Topic
MH  - Bipolar Disorder/*nursing/psychology
MH  - Culture
MH  - *Ego
MH  - *Ethics, Nursing
MH  - Humans
MH  - Interpersonal Relations
MH  - Narration
MH  - Psychotherapy
MH  - Social Sciences
MH  - United Kingdom
MH  - *Writing
EDAT- 2010/05/15 06:00
MHDA- 2010/10/01 06:00
CRDT- 2010/05/15 06:00
PHST- 2010/05/15 06:00 [entrez]
PHST- 2010/05/15 06:00 [pubmed]
PHST- 2010/10/01 06:00 [medline]
AID - JPM1478 [pii]
AID - 10.1111/j.1365-2850.2009.01478.x [doi]
PST - ppublish
SO  - J Psychiatr Ment Health Nurs. 2010 Mar;17(2):111-6. doi:
      10.1111/j.1365-2850.2009.01478.x.


PMID- 20465741
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20151119
IS  - 1365-2834 (Electronic)
IS  - 0966-0429 (Linking)
VI  - 18
IP  - 2
DP  - 2010 Mar
TI  - The skills gap in nursing management in South Africa: a sectoral analysis: a
      research paper.
PG  - 134-44
LID - 10.1111/j.1365-2834.2010.01063.x [doi]
AB  - AIM: To identify competencies important for effective nursing management and to
      assess managers' proficiency therein. BACKGROUND: A lack of management capacity
      has been identified as the key stumbling block to health delivery in South
      Africa. Despite nursing managers being central to overcoming the challenges
      facing health care, there has been a paucity of research that empirically
      evaluates their skill levels. METHODS: A survey was conducted among 171 senior
      nursing managers in South Africa using a self-administered questionnaire.
      RESULTS: Public sector managers assessed themselves as being relatively less
      competent than private sector managers. The largest skill gaps for public sector 
      managers were for 'ethico-legal', 'task-related' and 'controlling' skills whereas
      those for private sector managers were for 'ethico-legal', 'health-related ' and 
      'task-related' skills. CONCLUSIONS: This research confirmed the lack of
      management capacity within the health sector and identified areas in which the
      skills deficit was most significant for both the public and private sectors.
      IMPLICATIONS FOR NURSING MANAGEMENT: These findings reflect the needs of nursing 
      managers and will be useful in the conceptualization, design and delivery of
      health management programmes aimed at enhancing management and leadership
      capacity in the health sector in South Africa.
FAU - Pillay, Rubin
AU  - Pillay R
AD  - Alex G. McKenna School of Business, Government, and Economics, Saint Vincent
      College, Latrobe, PA 15650-2690, USA. rubin.pillay@email.stvincent.edu
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Nurs Manag
JT  - Journal of nursing management
JID - 9306050
MH  - Adult
MH  - Analysis of Variance
MH  - Clinical Competence
MH  - Cross-Sectional Studies
MH  - Factor Analysis, Statistical
MH  - Female
MH  - Health Care Surveys
MH  - Humans
MH  - *Leadership
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Nurse Administrators/*organization & administration
MH  - Nursing/*organization & administration
MH  - *Nursing, Supervisory
MH  - Private Sector
MH  - *Professional Competence
MH  - Public Sector
MH  - Self-Assessment
MH  - South Africa
MH  - Statistics as Topic
MH  - Surveys and Questionnaires
EDAT- 2010/05/15 06:00
MHDA- 2011/01/07 06:00
CRDT- 2010/05/15 06:00
PHST- 2010/05/15 06:00 [entrez]
PHST- 2010/05/15 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
AID - JNM1063 [pii]
AID - 10.1111/j.1365-2834.2010.01063.x [doi]
PST - ppublish
SO  - J Nurs Manag. 2010 Mar;18(2):134-44. doi: 10.1111/j.1365-2834.2010.01063.x.


PMID- 20465399
OWN - NLM
STAT- MEDLINE
DCOM- 20120322
LR  - 20100514
IS  - 1473-0782 (Electronic)
IS  - 1362-5187 (Linking)
VI  - 15
IP  - 3
DP  - 2010 Jun
TI  - Aspects of sexuality education in Europe - definitions, differences and
      developments.
PG  - 169-76
LID - 10.3109/13625181003797280 [doi]
AB  - OBJECTIVE: Sexuality education in Europe has been influenced by political, social
      and ethical movements. This paper considers some of these influences and the
      implementation of sexuality education in different parts of Europe. CONTENT: The 
      aim of sexuality education is to enable young people to acquire knowledge,
      attitudes, skills and values to make appropriate choices in their sexual
      behaviour and thus experience a healthy sex life that is age-appropriate. This
      should prevent them from acquiring or passing on sexually transmitted infections,
      including human immunodeficiency virus, from causing or suffering unwanted
      pregnancies, and from being the perpetrator or victim of violence. It should
      enhance understanding and respect diversity, thus contributing to a better
      society. Sexuality education as such has been widely recognised as essential for 
      sexual health, but the content and principles that form the basis of this
      education have changed over time and differ widely among the countries of Europe.
      CONCLUSION: Agreeing on common standards of sexuality education across Europe is 
      a challenge for the 21st century.
FAU - Loeber, Olga
AU  - Loeber O
AD  - Rutgershuis-Oost, Arnhem, The Netherlands. loejet@wxs.nl
FAU - Reuter, Simone
AU  - Reuter S
FAU - Apter, Dan
AU  - Apter D
FAU - van der Doef, Sanderijn
AU  - van der Doef S
FAU - Lazdane, Gunta
AU  - Lazdane G
FAU - Pinter, Bojana
AU  - Pinter B
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - England
TA  - Eur J Contracept Reprod Health Care
JT  - The European journal of contraception & reproductive health care : the official
      journal of the European Society of Contraception
JID - 9712127
SB  - IM
MH  - Europe
MH  - Female
MH  - History, 16th Century
MH  - History, 20th Century
MH  - History, Ancient
MH  - Human Rights
MH  - Humans
MH  - Male
MH  - *Sex Education/history/methods/standards
MH  - Sexual Behavior/history
MH  - Unsafe Sex/prevention & control
EDAT- 2010/05/15 06:00
MHDA- 2012/03/23 06:00
CRDT- 2010/05/15 06:00
PHST- 2010/05/15 06:00 [entrez]
PHST- 2010/05/15 06:00 [pubmed]
PHST- 2012/03/23 06:00 [medline]
AID - 10.3109/13625181003797280 [doi]
PST - ppublish
SO  - Eur J Contracept Reprod Health Care. 2010 Jun;15(3):169-76. doi:
      10.3109/13625181003797280.


PMID- 20465386
OWN - NLM
STAT- MEDLINE
DCOM- 20100813
LR  - 20100514
IS  - 1744-8301 (Electronic)
IS  - 1479-6694 (Linking)
VI  - 6
IP  - 5
DP  - 2010 May
TI  - Population fraction of cervical neoplasia attributable to high-risk human
      papillomaviruses.
PG  - 709-16
LID - 10.2217/fon.10.38 [doi]
AB  - AIMS: The efficacy of human papillomavirus (HPV) type 16 and 18 vaccines against 
      cervical intraepithelial neoplasia grade II (CIN2+) has been verified, but the
      active follow-up of studies with invasive cervical cancer or cervical
      intraepithelial neoplasia grade III (CIN3) as primary end points are ethically
      not possible. Furthermore, ongoing registry-based passive follow-up studies with 
      invasive cervical cancer as the end point will take time. MATERIALS & METHODS: To
      evaluate the feasibility of CIN3 as a surrogate end point, we compared high-risk 
      (hr) HPV-associated relative risk and population attributable fraction (PAF) of
      CIN3 and/or squamous cell carcinoma (SCC) estimated in a large serological
      case-cohort HPV study. Our case-cohort comprised 83 SCC and 389 CIN3 cases and a 
      subcohort of 7862 out of 230,998 Finnish women, who at baseline were under 32
      years of age and had undergone a minimum of two pregnancies within 5 years during
      1983-1997. RESULTS: PAFs of the case-cohort, approach-based, serologically
      defined and misclassification-corrected HPV16 and hrHPV (HPV types 16, 18, 31 and
      33) exposures in the SCC samples were 61% (95% CI: 18-85) and 73% (95% CI:
      13-93), respectively. Considerably lower HPV16 and hrHPV PAF estimates in CIN3 of
      6% (95% CI: -19-35) and 36% (95% CI: -5-65), respectively, were obtained. A
      meta-analysis-derived, PCR-based, hrHPV-associated relative risk estimate of 20.3
      in CIN2/3+ yielded a PAF estimate for hrHPV in CIN2/3+ of 86% (90% CI: 63-95) in 
      our study population. The former, hrHPV serology-based CIN3 PAF estimates were
      biased owing to low sensitivity of HPV16 and/or HPV16/18/31/33 serology, most
      notably in cervical cancer precursor lesions, but the latter estimate overlapped 
      with our hrHPV serology-based cervical cancer PAF estimate. CONCLUSION: CIN3 may 
      be a valid surrogate efficacy end point for HPV vaccination studies, but the
      associated causality of multiple hrHPV exposures needs to be unambigously
      defined.
FAU - Laukkanen, Paivi
AU  - Laukkanen P
AD  - National Institute for Health & Welfare, Helsinki & Oulu, Finland.
FAU - Laara, Esa
AU  - Laara E
FAU - Koskela, Pentti
AU  - Koskela P
FAU - Pukkala, Eero
AU  - Pukkala E
FAU - Virkkunen, Hanna
AU  - Virkkunen H
FAU - Lehtinen, Matti
AU  - Lehtinen M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Future Oncol
JT  - Future oncology (London, England)
JID - 101256629
RN  - 0 (E1 protein, Human papillomavirus type 31)
RN  - 0 (Papillomavirus Vaccines)
RN  - 0 (Viral Proteins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Carcinoma, Squamous Cell/*virology
MH  - Cervical Intraepithelial Neoplasia/*virology
MH  - Cohort Studies
MH  - Female
MH  - Human papillomavirus 16
MH  - Human papillomavirus 18
MH  - Humans
MH  - Meta-Analysis as Topic
MH  - Papillomavirus Infections/complications/*epidemiology
MH  - Papillomavirus Vaccines
MH  - Prevalence
MH  - Registries
MH  - Uterine Cervical Neoplasms/*virology
MH  - Viral Proteins
MH  - Young Adult
EDAT- 2010/05/15 06:00
MHDA- 2010/08/14 06:00
CRDT- 2010/05/15 06:00
PHST- 2010/05/15 06:00 [entrez]
PHST- 2010/05/15 06:00 [pubmed]
PHST- 2010/08/14 06:00 [medline]
AID - 10.2217/fon.10.38 [doi]
PST - ppublish
SO  - Future Oncol. 2010 May;6(5):709-16. doi: 10.2217/fon.10.38.


PMID- 20465351
OWN - NLM
STAT- MEDLINE
DCOM- 20100812
LR  - 20100514
IS  - 1943-278X (Electronic)
IS  - 0363-0234 (Linking)
VI  - 40
IP  - 2
DP  - 2010 Apr
TI  - Resolving ethical dilemmas in suicide prevention: the case of telephone helpline 
      rescue policies.
PG  - 159-69
LID - 10.1521/suli.2010.40.2.159 [doi]
AB  - The ethical basis of suicide prevention is illustrated by contrasting helpline
      emergency rescue policies of the Samaritans and the AAS and the U.S. National
      Suicide Prevention Lifeline network. We contrast moralist, relativist, and
      libertarian ethical premises and question whether suicide can be rational.
      Samaritans respect a caller's right to decide to die by suicide; U.S. helplines
      oblige emergency intervention during an attempt even against the caller's will.
      We analyze the effect of emergency rescue when there is high suicide risk but an 
      attempt has not been initiated. We examine links between values and actions,
      needs for empirical evidence to guide practice, and propose vigorous dialogue
      about values in the gray zone of moral practice.
FAU - Mishara, Brian L
AU  - Mishara BL
AD  - Centre for Research and Intervention on Suicide and Euthanasia, Psychology
      Department, Universite du Quebec a Montreal, Canada. mishara.brian@uqam.ca
FAU - Weisstub, David N
AU  - Weisstub DN
LA  - eng
PT  - Journal Article
PL  - England
TA  - Suicide Life Threat Behav
JT  - Suicide & life-threatening behavior
JID - 7608054
SB  - IM
MH  - Emergency Medical Services/ethics/legislation & jurisprudence
MH  - Hotlines/*ethics/legislation & jurisprudence
MH  - Humans
MH  - Models, Psychological
MH  - Suicide/*ethics/legislation & jurisprudence/*prevention & control
MH  - United States
EDAT- 2010/05/15 06:00
MHDA- 2010/08/13 06:00
CRDT- 2010/05/15 06:00
PHST- 2010/05/15 06:00 [entrez]
PHST- 2010/05/15 06:00 [pubmed]
PHST- 2010/08/13 06:00 [medline]
AID - 10.1521/suli.2010.40.2.159 [doi]
AID - 10.1521/suli.2010.40.2.159 [pii]
PST - ppublish
SO  - Suicide Life Threat Behav. 2010 Apr;40(2):159-69. doi:
      10.1521/suli.2010.40.2.159.


PMID- 20465149
OWN - NLM
STAT- MEDLINE
DCOM- 20100611
LR  - 20100514
IS  - 0890-1171 (Print)
IS  - 0890-1171 (Linking)
VI  - 24
IP  - 5
DP  - 2010 May-Jun
TI  - Virtual worlds: taking health promotion to new levels.
PG  - 344-6, iii
LID - 10.4278/ajhp.08042236 [doi]
AB  - Health promotion strategies continue to evolve, with interventions using e-mail, 
      text messaging, and Web sites becoming commonplace. The use of online virtual
      worlds is a less familiar venue for health promotion but offers numerous
      possibilities for wired citizens with health issues. The authors discuss three
      examples of virtual worlds--the River City Project, Whyville, and Second
      Life--and how health promotion strategies can be implemented in virtual worlds.
      They also address several challenges associated with implementing health
      interventions in virtual worlds, including questions of ethics, diffusion of
      health knowledge and logistics of intervening outside of the real world.
FAU - Annang, Lucy
AU  - Annang L
AD  - University of South Carolina, Arnold School of Public Health, Department of
      Health Promotion, Education, and Behavior, Columbia, SC 29208, USA.
      lannang@gwm.sc.edu
FAU - Muilenburg, Jessica L
AU  - Muilenburg JL
FAU - Strasser, Sheryl M
AU  - Strasser SM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Health Promot
JT  - American journal of health promotion : AJHP
JID - 8701680
MH  - Adolescent
MH  - Adult
MH  - *Electronic Mail
MH  - Ethics
MH  - Female
MH  - *Health Education
MH  - *Health Promotion
MH  - Humans
MH  - *Internet
MH  - Male
MH  - Research
MH  - Risk-Taking
EDAT- 2010/05/15 06:00
MHDA- 2010/06/12 06:00
CRDT- 2010/05/15 06:00
PHST- 2010/05/15 06:00 [entrez]
PHST- 2010/05/15 06:00 [pubmed]
PHST- 2010/06/12 06:00 [medline]
AID - 10.4278/ajhp.08042236 [doi]
PST - ppublish
SO  - Am J Health Promot. 2010 May-Jun;24(5):344-6, iii. doi: 10.4278/ajhp.08042236.


PMID- 20465075
OWN - NLM
STAT- MEDLINE
DCOM- 20100607
LR  - 20100514
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 21
IP  - 1
DP  - 2010 Spring
TI  - Breach notification and the law.
PG  - 42-3
AB  - The American Medical Association Council on Ethical and Judicial Affairs (CEJA)
      has written a position paper on physicians' ethical responsibilities in the event
      that the security of patients' electronic health information has been breached.
      The report offers compelling ethical and practical justifications for
      notification requirements and articulates guidelines for clinicians. This
      commentary addresses a gap in the report. It outlines the new legal duty to
      disclose security breaches, established by the 2009 HITECH Act, which is only
      briefly mentioned in the report. The commentary also analyzes the CEJA
      recommendations in light of the legal mandate and suggests that the guidance
      would benefit from further clarification.
FAU - Hoffman, Sharona
AU  - Hoffman S
AD  - Case Western Reserve University School of Law, Cleveland, Ohio, USA.
      sxh90@case.edu
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
CON - J Clin Ethics. 2010 Spring;21(1):30-5. PMID: 20465072
MH  - American Medical Association
MH  - Confidentiality/*legislation & jurisprudence
MH  - Electronic Health Records/ethics/*legislation & jurisprudence
MH  - Humans
MH  - *Physician's Role
MH  - Physician-Patient Relations/ethics
MH  - Practice Guidelines as Topic
MH  - *Truth Disclosure/ethics
MH  - United States
EDAT- 2010/05/15 06:00
MHDA- 2010/06/09 06:00
CRDT- 2010/05/15 06:00
PHST- 2010/05/15 06:00 [entrez]
PHST- 2010/05/15 06:00 [pubmed]
PHST- 2010/06/09 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2010 Spring;21(1):42-3.


PMID- 20465073
OWN - NLM
STAT- MEDLINE
DCOM- 20100607
LR  - 20100514
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 21
IP  - 1
DP  - 2010 Spring
TI  - Practicing preventive ethics, protecting patients: challenges of the electronic
      health record.
PG  - 36-8
AB  - Implementation of guidelines regarding breaches of electronic health information 
      requires an anticipatory stance and physician and patient education regarding
      security and monitoring measures and methods of redress. Adopting a preventive
      ethics, rather than a crisis management, model may also increase physician
      awareness of how the information they choose to include and privilege within the 
      health record may expose patients to added harms if not done mindfully.
FAU - Satkoske, Valerie B
AU  - Satkoske VB
AD  - University of Pittsburgh Center for Bioethics and Health Law, Pittsburgh,
      Pennsylvania, USA. valbridget@aol.com
FAU - Parker, Lisa S
AU  - Parker LS
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
CON - J Clin Ethics. 2010 Spring;21(1):30-5. PMID: 20465072
MH  - Confidentiality/*ethics/legislation & jurisprudence
MH  - Electronic Health Records/*ethics
MH  - Ethics, Medical
MH  - Humans
MH  - Medical Records Systems, Computerized/ethics
MH  - *Moral Obligations
MH  - *Physician's Role
MH  - Physician-Patient Relations/*ethics
MH  - Practice Guidelines as Topic
MH  - Primary Prevention/methods
MH  - United States
EDAT- 2010/05/15 06:00
MHDA- 2010/06/09 06:00
CRDT- 2010/05/15 06:00
PHST- 2010/05/15 06:00 [entrez]
PHST- 2010/05/15 06:00 [pubmed]
PHST- 2010/06/09 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2010 Spring;21(1):36-8.


PMID- 20465072
OWN - NLM
STAT- MEDLINE
DCOM- 20100607
LR  - 20100514
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 21
IP  - 1
DP  - 2010 Spring
TI  - A physician's role following a breach of electronic health information.
PG  - 30-5
AB  - The Council on Ethical and Judicial Affairs of the American Medical Association
      examines physicians' professional ethical responsibility in the event that the
      security of patients' electronic records is breached.
FAU - Kim, Daniel
AU  - Kim D
AD  - Ethics Standards Group, American Medical Association, Chicago, USA.
FAU - Schleiter, Kristin
AU  - Schleiter K
FAU - Crigger, Bette-Jane
AU  - Crigger BJ
FAU - McMahon, John W
AU  - McMahon JW
FAU - Benjamin, Regina M
AU  - Benjamin RM
FAU - Douglas, Sharon P
AU  - Douglas SP
CN  - Council on Ethical and Judicial Affairs, American Medical Association
LA  - eng
PT  - Journal Article
PT  - Practice Guideline
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
CIN - J Clin Ethics. 2010 Spring;21(1):36-8. PMID: 20465073
CIN - J Clin Ethics. 2010 Spring;21(1):39-41. PMID: 20465074
CIN - J Clin Ethics. 2010 Spring;21(1):42-3. PMID: 20465075
MH  - American Medical Association
MH  - Confidentiality/*ethics/legislation & jurisprudence
MH  - Conflict of Interest
MH  - Electronic Health Records/*ethics/legislation & jurisprudence
MH  - Ethics, Medical
MH  - Humans
MH  - *Moral Obligations
MH  - *Physician's Role
MH  - Physician-Patient Relations/*ethics
MH  - Trust
MH  - Truth Disclosure/*ethics
MH  - United States
IR  - Benjamin RM
FIR - Benjamin, Regina M
IR  - Stewart DM Jr
FIR - Stewart, Dudley M Jr
IR  - McMahon JW Sr
FIR - McMahon, John W Sr
IR  - Douglas SP
FIR - Douglas, Sharon P
IR  - Greene HR
FIR - Greene, H Rex
IR  - Goold SD
FIR - Goold, Susan D
IR  - McCormick P
FIR - McCormick, Patrick
IR  - Fairbrother H
FIR - Fairbrother, Hilary
IR  - Shah K
FIR - Shah, Kavita
IR  - Kao A
FIR - Kao, Audiey
IR  - Crigger BJ
FIR - Crigger, Bette-Jane
IR  - Scheiter K
FIR - Scheiter, Kristin
IR  - Kim D
FIR - Kim, Daniel
IR  - Shore R
FIR - Shore, Rebecca
EDAT- 2010/05/15 06:00
MHDA- 2010/06/09 06:00
CRDT- 2010/05/15 06:00
PHST- 2010/05/15 06:00 [entrez]
PHST- 2010/05/15 06:00 [pubmed]
PHST- 2010/06/09 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2010 Spring;21(1):30-5.


PMID- 20465070
OWN - NLM
STAT- MEDLINE
DCOM- 20100607
LR  - 20100514
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 21
IP  - 1
DP  - 2010 Spring
TI  - Toward competency-based certification of clinical ethics consultants: a four-step
      process.
PG  - 14-22
AB  - While consensus exists among many practitioners of ethics consultation about the 
      need for and identification of core competencies and standards, there has been
      virtually no attempt to determine how these competencies and standards are best
      taught and assessed. We believe that clinical ethics consultation has reached a
      state of sufficient maturity that expert practitioners can evaluate those who are
      new to the field. We will outline several steps that can facilitate the creation 
      of a certification process for clinical ethics consultants, assuring the
      competency and quality of consultation for the patients, families, and healthcare
      professionals who utilize ECSs.
FAU - Smith, Martin L
AU  - Smith ML
AD  - Department of Bioethics at the Cleveland Clinic in Cleveland, Ohio, USA.
      smithm24@ccf.org
FAU - Sharp, Richard R
AU  - Sharp RR
FAU - Weise, Kathryn
AU  - Weise K
FAU - Kodish, Eric
AU  - Kodish E
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
MH  - Certification/*standards/trends
MH  - Clinical Competence/standards
MH  - Communication
MH  - Competency-Based Education
MH  - *Consultants
MH  - Ethics Consultation
MH  - Humans
MH  - Patient Simulation
MH  - Professional Competence/*standards
MH  - *Professional Role
MH  - United States
EDAT- 2010/05/15 06:00
MHDA- 2010/06/09 06:00
CRDT- 2010/05/15 06:00
PHST- 2010/05/15 06:00 [entrez]
PHST- 2010/05/15 06:00 [pubmed]
PHST- 2010/06/09 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2010 Spring;21(1):14-22.


PMID- 20465069
OWN - NLM
STAT- MEDLINE
DCOM- 20100607
LR  - 20191210
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 21
IP  - 1
DP  - 2010 Spring
TI  - "Third generation" ethics: what careproviders should do before they do ethics.
PG  - 3-13
AB  - The author suggests that a "first generation" task in bioethics is to give
      patients the information they need; a "second generation" task is to do this in
      the most effective way; and a "third generation" task is to avoid harming
      patients by imposing value biases. The author discusses ways to pursue this third
      generation task.
FAU - Howe, Edmund G
AU  - Howe EG
AD  - Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
CON - J Clin Ethics. 2010 Spring;21(1):45-57. PMID: 20465076
MH  - Bioethics/*trends
MH  - Choice Behavior/ethics
MH  - *Consensus
MH  - Decision Making/*ethics
MH  - *Emotions
MH  - Ethical Analysis
MH  - Ethics Consultation/*standards/trends
MH  - Ethics, Clinical
MH  - Ethics, Medical
MH  - Humans
MH  - Imagination
MH  - Information Seeking Behavior
MH  - Informed Consent/*ethics/psychology
MH  - *Morals
MH  - Narration
MH  - *Power, Psychological
MH  - *Prejudice
MH  - Professional Competence
MH  - *Professional Role
MH  - Quality of Health Care/standards/trends
EDAT- 2010/05/15 06:00
MHDA- 2010/06/09 06:00
CRDT- 2010/05/15 06:00
PHST- 2010/05/15 06:00 [entrez]
PHST- 2010/05/15 06:00 [pubmed]
PHST- 2010/06/09 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2010 Spring;21(1):3-13.


PMID- 20464842
OWN - NLM
STAT- MEDLINE
DCOM- 20100603
LR  - 20211020
IS  - 0890-9091 (Print)
IS  - 0890-9091 (Linking)
VI  - 24
IP  - 4
DP  - 2010 Apr 15
TI  - Adjuvant hormonal therapy in premenopausal women with operable breast cancer:
      not-so-peripheral perspectives.
PG  - 322-7
AB  - Reviews of issues around adjuvant hormonal therapies for breast cancer in
      premenopausal women often focus on recent and current large clinical trials, and 
      fail to address other subjects that are very germane to evidence-based and
      investigatory clinical practice. These topics include: (1) the descriptive
      epidemiology of breast cancer globally, (2) critical issues in tumor hormone
      receptor testing, (3) compelling data demonstrating that hormone
      receptor-positive breast cancer is a chronic disease, (4) data supportive of
      combined hormonal therapy with tamoxifen as the standard of care, and the limited
      justifications for awaiting the SOFT and TEXT trial results, (5) pharmacogenetic 
      hypotheses with tamoxifen, (6) ethical issues in ovarian suppression vs ablative 
      treatment, and (7) emerging data about the importance of primary tumor removal
      surgery itself and "surgical stress" in solid tumor management.
FAU - Love, Richard R
AU  - Love RR
AD  - The Ohio State University Comprehensive Cancer Center Columbus, Ohio, USA.
      richard.love@osumc.edu
LA  - eng
GR  - R01 CA064339/CA/NCI NIH HHS/United States
GR  - R01 CA097375/CA/NCI NIH HHS/United States
GR  - R01 CA097375-08/CA/NCI NIH HHS/United States
GR  - CA 64339/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Oncology (Williston Park)
JT  - Oncology (Williston Park, N.Y.)
JID - 8712059
RN  - 0 (Antineoplastic Agents, Hormonal)
RN  - 33515-09-2 (Gonadotropin-Releasing Hormone)
SB  - IM
CIN - Oncology (Williston Park). 2010 Apr 15;24(4):331-2. PMID: 20464843
CIN - Oncology (Williston Park). 2010 Apr 15;24(4):332, 337, 340. PMID: 20464844
MH  - Antineoplastic Agents, Hormonal/*therapeutic use
MH  - Breast Neoplasms/*drug therapy/pathology/surgery
MH  - Chemotherapy, Adjuvant
MH  - Clinical Trials as Topic
MH  - Female
MH  - Gonadotropin-Releasing Hormone/*agonists
MH  - Humans
MH  - Ovariectomy
MH  - *Premenopause
MH  - Treatment Outcome
RF  - 62
PMC - PMC3073037
MID - NIHMS270133
EDAT- 2010/05/15 06:00
MHDA- 2010/06/04 06:00
CRDT- 2010/05/15 06:00
PHST- 2010/05/15 06:00 [entrez]
PHST- 2010/05/15 06:00 [pubmed]
PHST- 2010/06/04 06:00 [medline]
AID - 166656 [pii]
PST - ppublish
SO  - Oncology (Williston Park). 2010 Apr 15;24(4):322-7.


PMID- 20464771
STAT- Publisher
DA  - 20100514
ISBN- 9780309126663
ISBN- 0309126665
PB  - National Academies Press (US)
CTI - The National Academies Collection: Reports funded by National Institutes of
      Health
DP  - 2010
BTI - Crisis Standards of Care: Summary of a Workshop Series
AB  - In recent years, a number of federal, state, and local efforts have taken place
      to develop crisis standards of care protocols and policies for use in conditions 
      of overwhelming resource scarcity. Those involved in these efforts have begun to 
      carefully consider these difficult issues and to develop plans that are ethical, 
      consistent with the community's values, and implementable during a crisis. These 
      planning efforts are essential because, absent careful planning, there is
      enormous potential for confusion, chaos, and flawed decision making in a
      catastrophic public health emergency or disaster. However, although these efforts
      have accomplished a tremendous amount in just a few years, a great deal remains
      to be done in even the most advanced plan. Furthermore, the efforts have mainly
      been taking place independently, leading to a lack of consistency across
      neighboring jurisdictions and unnecessary duplication of effort. Lastly, many
      states have not yet substantially begun to develop policies and protocols for
      crisis standards of care during a mass casualty event. These issues prompted the 
      Institute of Medicine's (IOM's) Forum on Medical and Public Health Preparedness
      for Catastrophic Events (Preparedness Forum) to organize a series of regional
      workshops on this topic. These workshops were held in Irvine, CA; Orlando, FL;
      New York, NY; and Chicago, IL, between March and May of 2009.
CI  - Copyright (c) 2010, National Academy of Sciences.
CN  - Institute of Medicine (US) Forum on Medical and Public Health Preparedness for
      Catastrophic Events
LA  - eng
GR  - N01 OD042139/NIH HHS/United States
PT  - Review
PT  - Book
PL  - Washington (DC)
EDAT- 2010/05/14 06:00
MHDA- 2010/05/14 06:00
CDAT- 2010/05/14 06:00
AID - NBK32753 [bookaccession]
AID - 10.17226/12787 [doi]


PMID- 20464769
STAT- Publisher
DA  - 20100514
ISBN- 9780309146746
ISBN- 0309146747
PB  - National Academies Press (US)
CTI - The National Academies Collection: Reports funded by National Institutes of
      Health
DP  - 2010
BTI - Medical Surge Capacity: Workshop Summary
LID - 10.17226/12798 [doi]
AB  - The Hospital Preparedness Program (HPP) in HHS's ASPR sponsored the workshop on
      medical surge capacity. HPP's mission is to help prepare the nation's healthcare 
      system to respond appropriately to mass-casualty incidents, whether due to
      bioterrorism, natural disaster, or other public health emergencies. Ultimately,
      this effort comes down to preparedness and efficiency-health systems must develop
      a disaster medical capability that is rapid, flexible, sustainable, integrated,
      and coordinated, and that can deliver appropriate treatment in the most ethical
      manner with the resources and capabilities available. The workshop, held in
      Washington, DC, on June 10-11, 2009, featured presentations and discussions on
      the following topics, including the role of HPP in facilitating each of these
      efforts: Definitions of medical surge, standards, and metrics; Creating an
      integrated approach to an alternate care system, and establishing alternate care 
      facilities; The capability and tools available to local, state, territorial,
      tribal, and federal government entities to provide situational awareness during
      operations, and to assess the current status of preparedness for medical surge
      operations; Strategies to facilitate public- and private-sector work to improve
      surge capability for victims and the distressed, including vulnerable
      populations; and Issues related to financing surge and preparedness.
CI  - Copyright (c) 2010, National Academy of Sciences.
CN  - Institute of Medicine (US) Forum on Medical and Public Health Preparedness for
      Catastrophic Events
LA  - eng
GR  - N01-OD-4- 2139/NIH HHS/United States
PT  - Review
PT  - Book
PL  - Washington (DC)
EDAT- 2010/05/14 06:00
MHDA- 2010/05/14 06:00
CDAT- 2010/05/14 06:00
AID - NBK32859 [bookaccession]
AID - 10.17226/12798 [doi]


PMID- 20464760
OWN - NLM
STAT- MEDLINE
DCOM- 20100616
LR  - 20181221
IS  - 1469-493X (Electronic)
IS  - 1361-6137 (Linking)
IP  - 5
DP  - 2010 May 12
TI  - Embolisation therapy for pulmonary arteriovenous malformations.
PG  - CD008017
LID - 10.1002/14651858.CD008017.pub2 [doi]
AB  - BACKGROUND: Pulmonary arteriovenous malformations are abnormal direct connections
      between the pulmonary artery and pulmonary vein which result in a right-to-left
      shunt. They are associated with substantial morbidity and mortality mainly from
      the effects of paradoxical emboli. Potential complications include stroke,
      cerebral abscess, pulmonary haemorrhage and hypoxaemia. Embolisation therapy is a
      form of treatment based on the occlusion of the feeding arteries to a pulmonary
      arteriovenous malformation and can prevent many of these debilitating and
      life-threatening complications. OBJECTIVES: To determine the efficacy and safety 
      of embolisation therapy in people with pulmonary arteriovenous malformations
      including a comparison with surgical resection and different embolisation
      devices. SEARCH STRATEGY: We searched the Cystic Fibrosis and Genetic Disorders
      Group's Trials Registers (last searched 07 September 2009). We also searched the 
      following databases: the Australian New Zealand Clinical Trials Registry;
      ClinicalTrials.gov; International Standard Randomised Controlled Trial Number
      Register; International Clinical Trials Registry Platform Search Portal (last
      searched 22 November 2009). We checked cross-references and searched references
      from review articles. Finally, we contacted manufacturers and specialised centres
      for unpublished and ongoing trials. SELECTION CRITERIA: Trials in which
      individuals with pulmonary arteriovenous malformations were randomly allocated to
      embolisation therapy compared to no treatment, surgical resection or a different 
      embolisation device. Studies identified for potential inclusion were
      independently assessed for eligibility by two authors, with excluded studies
      further checked by a third author. DATA COLLECTION AND ANALYSIS: No trials were
      identified. As this was the case, no analysis was performed. MAIN RESULTS: There 
      were no randomised controlled trials identified. AUTHORS' CONCLUSIONS: Currently 
      there are no randomised controlled trials to support or refute embolisation
      therapy for treatment of pulmonary arteriovenous malformations. However,
      randomised controlled trials are not always feasible on ethical grounds.
      Observational studies suggest that embolisation therapy reduces mortality and
      morbidity compared to no treatment in patients. A standardised approach to
      reporting with long-term follow up through registry studies can help to
      strengthen the evidence base for embolisation therapy in the absence of
      randomised controlled trials. Future viable randomised controlled trials may
      compare different embolisation devices against each other.
FAU - Hsu, Charlie C-T
AU  - Hsu CC
AD  - The Alfred Hospital, Commercial Road, Prahran, Victoria, Australia, 3181.
FAU - Kwan, Gigi Nc
AU  - Kwan GN
FAU - Thompson, Shane A
AU  - Thompson SA
FAU - van Driel, Mieke L
AU  - van Driel ML
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20100512
PL  - England
TA  - Cochrane Database Syst Rev
JT  - The Cochrane database of systematic reviews
JID - 100909747
SB  - IM
UIN - Cochrane Database Syst Rev. 2012;8:CD008017. PMID: 22895972
MH  - Arteriovenous Malformations/*therapy
MH  - Embolization, Therapeutic/adverse effects/*methods
MH  - Humans
MH  - Pulmonary Artery/*abnormalities
MH  - Pulmonary Veins/*abnormalities
RF  - 41
EDAT- 2010/05/14 06:00
MHDA- 2010/06/17 06:00
CRDT- 2010/05/14 06:00
PHST- 2010/05/14 06:00 [entrez]
PHST- 2010/05/14 06:00 [pubmed]
PHST- 2010/06/17 06:00 [medline]
AID - 10.1002/14651858.CD008017.pub2 [doi]
PST - epublish
SO  - Cochrane Database Syst Rev. 2010 May 12;(5):CD008017. doi:
      10.1002/14651858.CD008017.pub2.


PMID- 20464744
OWN - NLM
STAT- MEDLINE
DCOM- 20100616
LR  - 20220408
IS  - 1469-493X (Electronic)
IS  - 1361-6137 (Linking)
IP  - 5
DP  - 2010 May 12
TI  - Interventions for improving the adoption of shared decision making by healthcare 
      professionals.
PG  - CD006732
LID - 10.1002/14651858.CD006732.pub2 [doi]
AB  - BACKGROUND: Shared decision making (SDM) is a process by which a healthcare
      choice is made jointly by the practitioner and the patient and is said to be the 
      crux of patient-centred care. Policy makers perceive SDM as desirable because of 
      its potential to a) reduce overuse of options not clearly associated with
      benefits for all (e.g., prostate cancer screening); b) enhance the use of options
      clearly associated with benefits for the vast majority (e.g., cardiovascular risk
      factor management); c) reduce unwarranted healthcare practice variations; d)
      foster the sustainability of the healthcare system; and e) promote the right of
      patients to be involved in decisions concerning their health. Despite this
      potential, SDM has not yet been widely adopted in clinical practice. OBJECTIVES: 
      To determine the effectiveness of interventions to improve healthcare
      professionals' adoption of SDM. SEARCH STRATEGY: We searched the following
      electronic databases up to 18 March 2009: Cochrane Library (1970-), MEDLINE
      (1966-), EMBASE (1976-), CINAHL (1982-) and PsycINFO (1965-). We found additional
      studies by reviewing a) the bibliographies of studies and reviews found in the
      electronic databases; b) the clinicaltrials.gov registry; and c) proceedings of
      the International Shared Decision Making Conference and the conferences of the
      Society for Medical Decision Making. We included all languages of publication.
      SELECTION CRITERIA: We included randomised controlled trials (RCTs) or
      well-designed quasi-experimental studies (controlled clinical trials, controlled 
      before and after studies, and interrupted time series analyses) that evaluated
      any type of intervention that aimed to improve healthcare professionals' adoption
      of shared decision making. We defined adoption as the extent to which healthcare 
      professionals intended to or actually engaged in SDM in clinical practice or/and 
      used interventions known to facilitate SDM. We deemed studies eligible if the
      primary outcomes were evaluated with an objective measure of the adoption of SDM 
      by healthcare professionals (e.g., a third-observer instrument). DATA COLLECTION 
      AND ANALYSIS: At least two reviewers independently screened each abstract for
      inclusion and abstracted data independently using a modified version of the EPOC 
      data collection checklist. We resolved disagreements by discussion. Statistical
      analysis considered categorical and continuous primary outcomes. We computed the 
      standard effect size for each outcome separately with a 95% confidence interval. 
      We evaluated global effects by calculating the median effect size and the range
      of effect sizes across studies. MAIN RESULTS: The reviewers identified 6764
      potentially relevant documents, of which we excluded 6582 by reviewing titles and
      abstracts. Of the remainder, we retrieved 182 full publications for more detailed
      screening. From these, we excluded 176 publications based on our inclusion
      criteria. This left in five studies, all RCTs. All five were conducted in
      ambulatory care: three in primary clinical care and two in specialised care. Four
      of the studies targeted physicians only and one targeted nurses only. In only two
      of the five RCTs was a statistically significant effect size associated with the 
      intervention to have healthcare professionals adopt SDM. The first of these two
      studies compared a single intervention (a patient-mediated intervention: the
      Statin Choice decision aid) to another single intervention (also
      patient-mediated: a standard Mayo patient education pamphlet). In this study, the
      Statin Choice decision aid group performed better than the standard Mayo patient 
      education pamphlet group (standard effect size = 1.06; 95% CI = 0.62 to 1.50).
      The other study compared a multifaceted intervention (distribution of educational
      material, educational meeting and audit and feedback) to usual care (control
      group) (standard effect size = 2.11; 95% CI = 1.30 to 2.90). This study was the
      only one to report an assessment of barriers prior to the elaboration of its
      multifaceted intervention. AUTHORS' CONCLUSIONS: The results of this Cochrane
      review do not allow us to draw firm conclusions about the most effective types of
      intervention for increasing healthcare professionals' adoption of SDM. Healthcare
      professional training may be important, as may the implementation of
      patient-mediated interventions such as decision aids. Given the paucity of
      evidence, however, those motivated by the ethical impetus to increase SDM in
      clinical practice will need to weigh the costs and potential benefits of
      interventions. Subsequent research should involve well-designed studies with
      adequate power and procedures to minimise bias so that they may improve estimates
      of the effects of interventions on healthcare professionals' adoption of SDM.
      From a measurement perspective, consensus on how to assess professionals'
      adoption of SDM is desirable to facilitate cross-study comparisons.
FAU - Legare, France
AU  - Legare F
AD  - Centre de recherche du Centre hospitalier universitaire de Quebec (CHUQ),
      St-Francois D'Assise Hospital, 10 rue de l'Espinay, Local D1-724, Quebec, Quebec,
      Canada, G1L 3L5.
FAU - Ratte, Stephane
AU  - Ratte S
FAU - Stacey, Dawn
AU  - Stacey D
FAU - Kryworuchko, Jennifer
AU  - Kryworuchko J
FAU - Gravel, Karine
AU  - Gravel K
FAU - Graham, Ian D
AU  - Graham ID
FAU - Turcotte, Stephane
AU  - Turcotte S
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20100512
PL  - England
TA  - Cochrane Database Syst Rev
JT  - The Cochrane database of systematic reviews
JID - 100909747
SB  - IM
UIN - Cochrane Database Syst Rev. 2014;9:CD006732. PMID: 25222632
MH  - *Decision Making
MH  - *Decision Support Techniques
MH  - Humans
MH  - Patient Education as Topic/methods
MH  - *Patient Participation
MH  - Randomized Controlled Trials as Topic
RF  - 93
EDAT- 2010/05/14 06:00
MHDA- 2010/06/17 06:00
CRDT- 2010/05/14 06:00
PHST- 2010/05/14 06:00 [entrez]
PHST- 2010/05/14 06:00 [pubmed]
PHST- 2010/06/17 06:00 [medline]
AID - 10.1002/14651858.CD006732.pub2 [doi]
PST - epublish
SO  - Cochrane Database Syst Rev. 2010 May 12;(5):CD006732. doi:
      10.1002/14651858.CD006732.pub2.


PMID- 20464461
OWN - NLM
STAT- MEDLINE
DCOM- 20110325
LR  - 20211020
IS  - 1573-904X (Electronic)
IS  - 0724-8741 (Linking)
VI  - 28
IP  - 1
DP  - 2011 Jan
TI  - In vivo, in situ imaging of microneedle insertion into the skin of human
      volunteers using optical coherence tomography.
PG  - 66-81
LID - 10.1007/s11095-010-0167-x [doi]
AB  - PURPOSE: To gather sub-surface in situ images of microneedle-treated human skin, 
      in vivo, using optical coherence tomography (OCT). This is the first study to
      utilise OCT to investigate the architectural changes that are induced in skin
      following microneedle application. METHODS: Steel, silicon and polymer
      microneedle devices, with different microneedle arrangements and morphologies,
      were applied to two anatomical sites in human volunteers following appropriate
      ethical approval. A state-of-the-art ultrahigh resolution OCT imaging system
      operating at 800 nm wavelength and <3 microm effective axial resolution was used 
      to visualise the microneedle-treated area during insertion and/or following
      removal of the device, without any tissue processing. RESULTS: Transverse images 
      of a microneedle device, in situ, were captured by the OCT system and suggest
      that the stratified skin tissue is compressed during microneedle application.
      Following removal of the device, the created microchannels collapse within the in
      vivo environment and, therefore, for all studied devices, microconduit dimensions
      are markedly smaller than the microneedle dimensions. CONCLUSIONS: Microchannels 
      created in the upper skin layers by microneedles are less invasive than previous 
      histology predicts. OCT has the potential to play a highly influential role in
      the future development of microneedle devices and other transdermal delivery
      systems.
FAU - Coulman, Sion A
AU  - Coulman SA
AD  - Gene Delivery Research Group, Welsh School of Pharmacy, Cardiff University,
      Cardiff, CF10 3NB, UK. coulmansa@cardiff.ac.uk
FAU - Birchall, James C
AU  - Birchall JC
FAU - Alex, Aneesh
AU  - Alex A
FAU - Pearton, Marc
AU  - Pearton M
FAU - Hofer, Bernd
AU  - Hofer B
FAU - O'Mahony, Conor
AU  - O'Mahony C
FAU - Drexler, Wolfgang
AU  - Drexler W
FAU - Povazay, Boris
AU  - Povazay B
LA  - eng
GR  - Biotechnology and Biological Sciences Research Council/United Kingdom
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20100513
PL  - United States
TA  - Pharm Res
JT  - Pharmaceutical research
JID - 8406521
SB  - IM
MH  - Adult
MH  - Drug Delivery Systems/instrumentation/*methods
MH  - Equipment Design
MH  - Humans
MH  - Injections, Intradermal
MH  - Male
MH  - Microinjections/instrumentation/*methods
MH  - Microscopy, Electron, Scanning
MH  - *Needles
MH  - Skin/metabolism/*ultrastructure
MH  - Surface Properties
MH  - Technology, Pharmaceutical/methods
MH  - *Tomography, Optical Coherence
MH  - Young Adult
EDAT- 2010/05/14 06:00
MHDA- 2011/03/26 06:00
CRDT- 2010/05/14 06:00
PHST- 2010/01/19 00:00 [received]
PHST- 2010/04/28 00:00 [accepted]
PHST- 2010/05/14 06:00 [entrez]
PHST- 2010/05/14 06:00 [pubmed]
PHST- 2011/03/26 06:00 [medline]
AID - 10.1007/s11095-010-0167-x [doi]
PST - ppublish
SO  - Pharm Res. 2011 Jan;28(1):66-81. doi: 10.1007/s11095-010-0167-x. Epub 2010 May
      13.


PMID- 20464261
OWN - NLM
STAT- MEDLINE
DCOM- 20101220
LR  - 20220408
IS  - 1518-8787 (Electronic)
IS  - 0034-8910 (Linking)
VI  - 44
IP  - 3
DP  - 2010 Jun
TI  - Overlapping of duties and technical autonomy among nurses of the Family Health
      Strategy.
PG  - 520-7
LID - S0034-89102010005000011 [pii]
AB  - OBJECTIVE: To understand how Estrategia Saude da Familia (Family Health Strategy)
      nurses experience the overlapping of duties and building of technical autonomy.
      METHODOLOGICAL PROCEDURES: This was a qualitative study performed with 22 nurses,
      in the city of Recife, Northeastern Brazil, between August 2005 and November
      2006. Based on management evaluation (geographic access; conflicts in the team,
      between team and district and between team and community; and public violence in 
      the area), four teams were selected in each of the six health districts.
      Semi-structured interviews were conducted. The main themes in the interview guide
      were about work expectations and relevance, its organization and process, and
      feelings towards these practices. The results were interpreted under the
      perspective of burnout. ANALYSIS OF RESULTS: The nurses' opinion on the excessive
      number of families, insufficient organizational support and pressures from user
      demands that had not been met was recurrent. Overlapping of health care and
      management caused work overload, creating anxiety, impotence, frustration and the
      feeling of being treated unfairly when tasks were divided among team members. The
      clinical dimension of practice led to a feeling of insecurity of a technical and 
      ethical nature, in addition to the satisfaction for the power and prestige
      achieved by the professional category. Specialized medical training represented
      an obstacle to autonomy and responsibility becoming interdependent. Stress,
      dissatisfaction, becoming physically and mentally ill, recognition of the
      relevance of work and importance of one's performance, and low work involvement
      were reported. CONCLUSIONS: In view of the lack of expectation of changes in the 
      short term, the overlapping of low professional satisfaction and work overload
      causes negative attitudes, indicating the importance of health promotion to
      increase the possibility of influencing and changing work conditions.
FAU - Feliciano, Katia Virginia de Oliveira
AU  - Feliciano KV
AD  - Instituto de Medicina Integral Prof. Fernando Figueira, Recife, PE, Brazil.
      katia.feliciano@imip.org.br <katia.feliciano@imip.org.br>
FAU - Kovacs, Maria Helena
AU  - Kovacs MH
FAU - Sarinho, Silvia Wanick
AU  - Sarinho SW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100514
PL  - Brazil
TA  - Rev Saude Publica
JT  - Revista de saude publica
JID - 0135043
SB  - IM
MH  - Brazil
MH  - Burnout, Professional/*psychology
MH  - Conflict, Psychological
MH  - Family Nursing/organization & administration
MH  - Female
MH  - Humans
MH  - Interprofessional Relations
MH  - Job Satisfaction
MH  - Nursing Staff/*organization & administration/psychology
MH  - Nursing, Supervisory/*organization & administration
MH  - *Professional Autonomy
MH  - Qualitative Research
MH  - Surveys and Questionnaires
MH  - *Workload
EDAT- 2010/05/14 06:00
MHDA- 2010/12/21 06:00
CRDT- 2010/05/14 06:00
PHST- 2009/05/19 00:00 [received]
PHST- 2009/12/13 00:00 [accepted]
PHST- 2010/05/14 06:00 [entrez]
PHST- 2010/05/14 06:00 [pubmed]
PHST- 2010/12/21 06:00 [medline]
AID - S0034-89102010005000011 [pii]
AID - 10.1590/s0034-89102010005000011 [doi]
PST - ppublish
SO  - Rev Saude Publica. 2010 Jun;44(3):520-7. doi: 10.1590/s0034-89102010005000011.
      Epub 2010 May 14.


PMID- 20464200
OWN - NLM
STAT- MEDLINE
DCOM- 20100901
LR  - 20190907
IS  - 1678-4561 (Electronic)
IS  - 1413-8123 (Linking)
VI  - 15
IP  - 3
DP  - 2010 May
TI  - [Ethical problems experienced by dentists: dealing with bioethics to wide the
      view on the daily professional practice].
PG  - 869-78
LID - S1413-81232010000300030 [pii]
AB  - Bioethics strives for humanization in health services along with promoting the
      rights of patients. In view of the lack of dental research dealing with this
      topic, the present study was undertaken to identify, from the viewpoint of dental
      surgeons, ethical problems experienced in dental practice. It is a descriptive
      exploratory investigation within a qualitative approach. Empirical material was
      collected through semi-structured interviews performed with 15 dental surgeons in
      the state of Rio Grande do Norte, Brazil. The results indicate that many of the
      ethical problems coincide with infringements of the norms and rules of the Dental
      Code of Ethics, confirming a dental ethic acquired during professional formation 
      and therefore, inadequate for solving the problems that emerge in professional
      practice. We concluded that the ethical problems identified in professional
      practice need to be understood beyond the dental dimension, towards a human
      approach. It is therefore necessary to incorporate health care management
      technologies into health practices which imply recognizing the different
      dimensions that surround individuals and their health needs.
FAU - Amorim, Adriana Gomes
AU  - Amorim AG
AD  - Universidade do Estado do Rio Grande do Norte, Caico, RN, 59300-000.
      Adrianagamorim1@hotmail.com
FAU - Souza, Elizabethe Cristina Fagundes de
AU  - Souza EC
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Problemas eticos vivenciados por dentistas: dialogando com a bioetica para
      ampliar o olhar sobre o cotidiano da pratica profissional.
PL  - Brazil
TA  - Cien Saude Colet
JT  - Ciencia & saude coletiva
JID - 9713483
SB  - IM
MH  - *Bioethical Issues
MH  - Brazil
MH  - *Ethics, Dental
MH  - Health Services/ethics
MH  - Humans
EDAT- 2010/05/14 06:00
MHDA- 2010/09/02 06:00
CRDT- 2010/05/14 06:00
PHST- 2007/03/26 00:00 [received]
PHST- 2007/06/15 00:00 [accepted]
PHST- 2010/05/14 06:00 [entrez]
PHST- 2010/05/14 06:00 [pubmed]
PHST- 2010/09/02 06:00 [medline]
AID - S1413-81232010000300030 [pii]
AID - 10.1590/s1413-81232010000300030 [doi]
PST - ppublish
SO  - Cien Saude Colet. 2010 May;15(3):869-78. doi: 10.1590/s1413-81232010000300030.


PMID- 20464065
OWN - NLM
STAT- MEDLINE
DCOM- 20101027
LR  - 20220310
IS  - 1678-4464 (Electronic)
IS  - 0102-311X (Linking)
VI  - 26
IP  - 3
DP  - 2010 Mar
TI  - [Characterization of lawsuits for the supply of "essential" medicines in the
      State of Rio de Janeiro, Brazil].
PG  - 461-71
LID - S0102-311X2010000300004 [pii]
AB  - Recognition of the right to health raises two practical issues: the government's 
      ethical and legal duty to ensure comprehensive health care and citizens' recourse
      to legal action to guarantee this right. This study focused on lawsuits to demand
      "essential" medicines, filed at the State Court of Appeals in Rio de Janeiro,
      Brazil, in 2006. One hundred and eighty-five suits were examined, and the claims 
      were granted in all but three cases. Median times between filing the suit, the
      injunction, first ruling, and appellate ruling were 7, 239, and 478 days
      respectively. In 80.6% of the 98 suits in which the specific medicines could be
      identified, at least one drug did not belong to any publicly funded list of
      medicines. This could indicate that lawsuits demanding "essential" drugs were
      motivated not only by problems in procurement, distribution, and dispensing of
      medicines but also by non-inclusion of medicines on official lists. Most of the
      medicines demanded through lawsuits were for conditions involving the
      cardiovascular and nervous systems.
FAU - Pepe, Vera Lucia Edais
AU  - Pepe VL
AD  - Escola Nacional de Saude Publica Sergio Arouca, Fundacao Oswaldo Cruz, Rio de
      Janeiro, Brasil. verapepe@ensp.fiocruz.br
FAU - Ventura, Miriam
AU  - Ventura M
FAU - Sant'ana, Joao Mauricio Brambati
AU  - Sant'ana JM
FAU - Figueiredo, Tatiana Aragao
AU  - Figueiredo TA
FAU - Souza, Vanessa Dos Reis de
AU  - Souza Vdos R
FAU - Simas, Luciana
AU  - Simas L
FAU - Osorio-de-Castro, Claudia Garcia Serpa
AU  - Osorio-de-Castro CG
LA  - por
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
TT  - Caracterizacao de demandas judiciais de fornecimento de medicamentos "essenciais"
      no Estado do Rio de Janeiro, Brasil.
PL  - Brazil
TA  - Cad Saude Publica
JT  - Cadernos de saude publica
JID - 8901573
RN  - 0 (Drugs, Essential)
SB  - IM
MH  - Brazil
MH  - Drugs, Essential/*supply & distribution
MH  - Health Services Accessibility/*legislation & jurisprudence/standards
MH  - Humans
MH  - Patient Advocacy/*legislation & jurisprudence/statistics & numerical data
MH  - Patient Rights/legislation & jurisprudence
MH  - Retrospective Studies
EDAT- 2010/05/14 06:00
MHDA- 2010/10/28 06:00
CRDT- 2010/05/14 06:00
PHST- 2009/07/10 00:00 [received]
PHST- 2010/01/07 00:00 [accepted]
PHST- 2010/05/14 06:00 [entrez]
PHST- 2010/05/14 06:00 [pubmed]
PHST- 2010/10/28 06:00 [medline]
AID - S0102-311X2010000300004 [pii]
AID - 10.1590/s0102-311x2010000300004 [doi]
PST - ppublish
SO  - Cad Saude Publica. 2010 Mar;26(3):461-71. doi: 10.1590/s0102-311x2010000300004.


PMID- 20463099
OWN - NLM
STAT- MEDLINE
DCOM- 20100726
LR  - 20100708
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 95
IP  - 7
DP  - 2010 Jul
TI  - A missense glial cells missing homolog B (GCMB) mutation, Asn502His, causes
      autosomal dominant hypoparathyroidism.
PG  - 3512-6
LID - 10.1210/jc.2009-2532 [doi]
AB  - CONTEXT: Glial cells missing B (GCMB), the mammalian homolog of the Drosophila
      GCM gene, encodes a 506-amino-acid parathyroid-specific transcription factor. To 
      date, only two different heterozygous GCMB mutations have been reported in three 
      kindreds with autosomal dominant hypoparathyroidism. OBJECTIVE: Our objective was
      to investigate a family with autosomal dominant hypoparathyroidism for PTH, CaSR,
      and GCMB mutations. METHODS: Leukocyte DNA was used with exon-specific primers
      for PCR amplification and the DNA sequences of the PCR products determined.
      Functional analyses using fluorescence microscopy, EMSAs, and luciferase reporter
      assays were undertaken. Informed consent was obtained using protocols approved by
      a national ethical committee. RESULTS: DNA sequence analysis revealed an A to C
      transversion at codon 502 of GCMB, which altered the wild-type asparagine (Asn)
      to histidine (His). Functional studies, using transient transfections of COS7
      cells with GCMB wild-type and mutant (Asn502His) tagged constructs, demonstrated 
      that the wild-type and mutant proteins localized to the nucleus and retained the 
      ability to bind the GCM-consensus DNA recognition motif. However, a luciferase
      reporter assay demonstrated that the Asn502His mutation resulted in a reduction
      in gene transactivation. Moreover, cotransfection of the wild-type with mutant
      did not lead to an increase in luciferase activity, thereby demonstrating a
      dominant-negative effect of the Asn502His mutant that would be consistent with an
      autosomal dominant inheritance. CONCLUSION: Our results, which have identified
      the first dominant missense GCMB mutation, help to increase our understanding of 
      the mechanism underlying gene transactivation that is a prerequisite for the
      function of this parathyroid gland-specific transcription factor.
FAU - Mirczuk, Samantha M
AU  - Mirczuk SM
AD  - Academic Endocrine Unit, Nuffield Department of Clinical Medicine, University of 
      Oxford, Oxford Centre for Diabetes, Endocrinology, and Metabolism (OCDEM),
      Churchill Hospital, Headington Oxford OX3 7LJ, UK.
FAU - Bowl, Michael R
AU  - Bowl MR
FAU - Nesbit, M Andrew
AU  - Nesbit MA
FAU - Cranston, Treena
AU  - Cranston T
FAU - Fratter, Carl
AU  - Fratter C
FAU - Allgrove, Jeremy
AU  - Allgrove J
FAU - Brain, Caroline
AU  - Brain C
FAU - Thakker, Rajesh V
AU  - Thakker RV
LA  - eng
GR  - G9825289/Medical Research Council/United Kingdom
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100512
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (GCM2 protein, human)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Blotting, Western
MH  - Electrophoretic Mobility Shift Assay
MH  - Humans
MH  - Hypoparathyroidism/*genetics
MH  - Microscopy, Fluorescence
MH  - Mutation, Missense/*genetics
MH  - Nuclear Proteins/*genetics
MH  - Polymerase Chain Reaction
MH  - Transcription Factors/*genetics
EDAT- 2010/05/14 06:00
MHDA- 2010/07/27 06:00
CRDT- 2010/05/14 06:00
PHST- 2010/05/14 06:00 [entrez]
PHST- 2010/05/14 06:00 [pubmed]
PHST- 2010/07/27 06:00 [medline]
AID - jc.2009-2532 [pii]
AID - 10.1210/jc.2009-2532 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2010 Jul;95(7):3512-6. doi: 10.1210/jc.2009-2532. Epub
      2010 May 12.


PMID- 20462929
OWN - NLM
STAT- MEDLINE
DCOM- 20100518
LR  - 20181023
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 340
DP  - 2010 May 12
TI  - What to tell junior doctors about ethics.
PG  - c2489
LID - 10.1136/bmj.c2489 [doi]
LID - bmj.c2489 [pii]
FAU - Sokol, Daniel K
AU  - Sokol DK
AD  - Imperial College London. daniel.sokol@talk21.com
LA  - eng
PT  - Journal Article
DEP - 20100512
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
SB  - IM
MH  - Confidentiality/ethics
MH  - Ethics, Institutional
MH  - Ethics, Medical
MH  - Medical Staff, Hospital/*ethics
MH  - Resuscitation Orders/ethics
MH  - Whistleblowing/ethics
EDAT- 2010/05/14 06:00
MHDA- 2010/05/19 06:00
CRDT- 2010/05/14 06:00
PHST- 2010/05/14 06:00 [entrez]
PHST- 2010/05/14 06:00 [pubmed]
PHST- 2010/05/19 06:00 [medline]
AID - 10.1136/bmj.c2489 [doi]
PST - epublish
SO  - BMJ. 2010 May 12;340:c2489. doi: 10.1136/bmj.c2489.


PMID- 20462678
OWN - NLM
STAT- MEDLINE
DCOM- 20100928
LR  - 20131121
IS  - 1879-1271 (Electronic)
IS  - 0268-0033 (Linking)
VI  - 25
IP  - 6
DP  - 2010 Jul
TI  - Postural control in healthy individuals.
PG  - 546-51
LID - 10.1016/j.clinbiomech.2010.03.005 [doi]
AB  - BACKGROUND: The aim of rehabilitation is to optimize functional recovery and
      frequently following injury, the uninjured limb is used as measure to compare
      with the injured limb. This assumes that symmetry existed prior to the injury.
      The aim of this study was to examine postural control in a healthy sample to
      ascertain if differences exist between the functionally dominant compared to
      non-dominant limbs. METHODS: Following ethical approval, 20 healthy active
      subjects (10 males and 10 females) mean age (SE) of 27.2 (1.4) years, with no
      previous history of lower-limb injury or pathology volunteered to participate in 
      the study. Bilateral joint angle data was acquired to establish the amount of
      wobble and the strategies of movement used to maintain balance during single-leg 
      stance. FINDINGS: A greater proportion of non-dominant limbs used the ankle
      strategy, commonly modelled as an inverted pendulum, to maintain balance during
      unipedal stance (p>0.003) in the sagittal plane. No differences were found in the
      coronal plane or for wobble. INTERPRETATION: A greater proportion of the healthy 
      individuals were more pendular-like when balancing on the non-dominant limb. Thus
      an assessment of joint angle changes during single-leg stance may provide greater
      insight into the postural control strategies and capabilities of healthy active
      individuals, which may inform future rehabilitation programmes in order to
      optimize functional outcome.
CI  - Crown Copyright (c) 2010. Published by Elsevier Ltd. All rights reserved.
FAU - Clifford, Amanda Marie
AU  - Clifford AM
AD  - Physiotherapy Dept., Faculty of Education and Health Sciences, University of
      Limerick, Limerick, Ireland. amanda.clifford@ul.ie
FAU - Holder-Powell, Heather
AU  - Holder-Powell H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100513
PL  - England
TA  - Clin Biomech (Bristol, Avon)
JT  - Clinical biomechanics (Bristol, Avon)
JID - 8611877
SB  - IM
MH  - Adult
MH  - Ankle/pathology
MH  - Biomechanical Phenomena
MH  - Ethics, Medical
MH  - Extremities
MH  - Female
MH  - Humans
MH  - Kinesics
MH  - Male
MH  - Movement
MH  - Postural Balance/*physiology
MH  - *Posture
EDAT- 2010/05/14 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/05/14 06:00
PHST- 2009/07/23 00:00 [received]
PHST- 2010/03/04 00:00 [revised]
PHST- 2010/03/08 00:00 [accepted]
PHST- 2010/05/14 06:00 [entrez]
PHST- 2010/05/14 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - S0268-0033(10)00090-2 [pii]
AID - 10.1016/j.clinbiomech.2010.03.005 [doi]
PST - ppublish
SO  - Clin Biomech (Bristol, Avon). 2010 Jul;25(6):546-51. doi:
      10.1016/j.clinbiomech.2010.03.005. Epub 2010 May 13.


PMID- 20462652
OWN - NLM
STAT- MEDLINE
DCOM- 20110307
LR  - 20141120
IS  - 1872-7565 (Electronic)
IS  - 0169-2607 (Linking)
VI  - 100
IP  - 3
DP  - 2010 Dec
TI  - Statistical modeling of psychosis data.
PG  - 222-36
LID - 10.1016/j.cmpb.2010.03.017 [doi]
AB  - Psychosis is a special type of mental disorder that affects around 2-3% of global
      population and has a strong genetic basis. Under psychosis, there is a group of
      diseases, which apparently may look alike and thus, it is difficult to isolate
      them from each other. Moreover, the credibility of real data related to psychosis
      is not only questionable due to its secondary nature but also its availability is
      grossly restricted because of the ethical constraints and prevailing social
      taboo. The present paper is a novel attempt to capture psychosis data by
      considering 24 input symptom constructs and 7 tentative responses (outputs) as
      per Brief Psychiatric Rating Scale-F2 (BPRS-F2). The captured input-output data
      as per Plackett-Burman design (PBD) of experiments (after consulting 40
      psychiatrists) are statistically modeled, to determine their mutual relationships
      (i.e., outputs as the functions of inputs). Both Pareto-charts as well as normal 
      probability plots are prepared to investigate the effect of each factor on
      different responses. Significant symptom construct(s) has/have been identified
      for each response. For example, emotional withdrawal has significant contribution
      towards schizophrenia, and so on. The psychosis data, thus collected, will be
      useful for further processing to extract more information of the said disease.
CI  - Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Chattopadhyay, S
AU  - Chattopadhyay S
AD  - School of Information Technology, Indian Institute of Technology, Kharagpur,
      India. subhagatachatterjee@yahoo.com
FAU - Pratihar, D K
AU  - Pratihar DK
FAU - De Sarkar, S C
AU  - De Sarkar SC
LA  - eng
PT  - Journal Article
DEP - 20100511
PL  - Ireland
TA  - Comput Methods Programs Biomed
JT  - Computer methods and programs in biomedicine
JID - 8506513
SB  - IM
MH  - *Data Collection
MH  - *Data Interpretation, Statistical
MH  - Global Health
MH  - Humans
MH  - *Models, Statistical
MH  - Psychometrics
MH  - Psychotic Disorders/*epidemiology/genetics
MH  - Regression Analysis
MH  - Software
MH  - Statistics as Topic
EDAT- 2010/05/14 06:00
MHDA- 2011/03/08 06:00
CRDT- 2010/05/14 06:00
PHST- 2009/06/25 00:00 [received]
PHST- 2010/01/30 00:00 [revised]
PHST- 2010/03/26 00:00 [accepted]
PHST- 2010/05/14 06:00 [entrez]
PHST- 2010/05/14 06:00 [pubmed]
PHST- 2011/03/08 06:00 [medline]
AID - S0169-2607(10)00069-6 [pii]
AID - 10.1016/j.cmpb.2010.03.017 [doi]
PST - ppublish
SO  - Comput Methods Programs Biomed. 2010 Dec;100(3):222-36. doi:
      10.1016/j.cmpb.2010.03.017. Epub 2010 May 11.


PMID- 20462441
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1750-9378 (Electronic)
IS  - 1750-9378 (Linking)
VI  - 5
DP  - 2010 May 12
TI  - The impact of antiretroviral therapy on HPV and cervical intraepithelial
      neoplasia: current evidence and directions for future research.
PG  - 8
LID - 10.1186/1750-9378-5-8 [doi]
AB  - Increasing numbers of human immunodeficiency virus (HIV)-infected women are now
      accessing life-prolonging highly active antiretroviral therapy (HAART) in
      developing countries. There is a need for better understanding of interactions of
      human papillomavirus (HPV) and HIV, especially in the context of increasing life 
      expectancy due to HAART. The data regarding the impact of HAART on reducing the
      incidence and progression and facilitating the regression of HPV infection and
      cervical abnormalities is largely inconsistent. Published studies differ in their
      study designs (prospective or retrospective cohorts or record linkage studies),
      screening and diagnostic protocols, duration and type of HAART use, recruitment
      and referral strategies, and definitions of screening test and disease
      positivity. Due to the ethical and resource limitations in conducting randomized 
      trials of the impact of HAART on incidence of HPV, CIN, and cervical cancer among
      HIV-infected women, it is important to consider innovative study designs,
      including quasi-experimental trials and operations research in sentinel
      populations to answer the critical research questions in this area.
FAU - Bratcher, Lara F
AU  - Bratcher LF
AD  - Institute for Global Health and Department of Pediatrics, Vanderbilt University
      School of Medicine, Nashville, USA. vikrant.sahasrabuddhe@vanderbilt.edu.
FAU - Sahasrabuddhe, Vikrant V
AU  - Sahasrabuddhe VV
LA  - eng
GR  - D43 TW001035/TW/FIC NIH HHS/United States
GR  - R21 CA113465/CA/NCI NIH HHS/United States
PT  - Journal Article
DEP - 20100512
PL  - England
TA  - Infect Agent Cancer
JT  - Infectious agents and cancer
JID - 101276559
PMC - PMC2881893
EDAT- 2010/05/14 06:00
MHDA- 2010/05/14 06:01
CRDT- 2010/05/14 06:00
PHST- 2009/07/29 00:00 [received]
PHST- 2010/05/12 00:00 [accepted]
PHST- 2010/05/14 06:00 [entrez]
PHST- 2010/05/14 06:00 [pubmed]
PHST- 2010/05/14 06:01 [medline]
AID - 1750-9378-5-8 [pii]
AID - 10.1186/1750-9378-5-8 [doi]
PST - epublish
SO  - Infect Agent Cancer. 2010 May 12;5:8. doi: 10.1186/1750-9378-5-8.


PMID- 20462417
OWN - NLM
STAT- MEDLINE
DCOM- 20101102
LR  - 20211020
IS  - 1472-6963 (Electronic)
IS  - 1472-6963 (Linking)
VI  - 10
DP  - 2010 May 12
TI  - Risk reduction before surgery. The role of the primary care provider in
      preoperative smoking and alcohol cessation.
PG  - 121
LID - 10.1186/1472-6963-10-121 [doi]
AB  - BACKGROUND: Daily smokers and hazardous drinkers are high-risk patients,
      developing 2-4 times more complications after surgery. Preoperative smoking and
      alcohol cessation for four to eight weeks prior to surgery halves this
      complication rate. The patients' preoperative contact with the surgical
      departments might be too brief for the hospital to initiate these programmes.
      Therefore, it was relevant to evaluate a new clinical practice which combined the
      general practitioner's (GP) referral to surgery with a referral to a smoking and 
      alcohol intervention in the surgical pathway. METHODS: The design was an
      exploratory prospective trial. The outcome measured was the number of patients
      referred to a preoperative smoking and alcohol cessation programme at the same
      time as being referred for elective surgery by their GP. The participants
      consisted of 72 high-risk patients who were referred for elective surgery by 47
      local participating GPs. The GPs, nurses, and specialists in internal medicine,
      prehabilitation and surgery developed new clinical practice guidelines based on
      the literature and interviews with 11 local GPs about the specific barriers for
      implementing a smoking and alcohol cessation programme. The role of the GP was to
      be the gatekeeper: identifying daily smokers and hazardous drinkers when
      referring them to surgery; handing out information on risk reduction; and
      referring those patients identified to a preoperative smoking and alcohol
      cessation programme. The role of the hospital was to contact these patients to
      initiate smoking and alcohol cessation at the hospital out-patient clinic for
      life-style intervention. RESULTS: The GPs increased their referral to the smoking
      and alcohol cessation programme from 0% to 10% (7/72 patients) in the study
      period. CONCLUSION: The effect of the study was limited in integrating the
      efforts of primary care providers and hospital surgical departments in increasing
      the up-take of preoperative smoking and alcohol cessation programmes aimed at
      smokers and harmful drinkers referred for surgery. New strategies for cooperation
      between GPs and surgical departments are urgently needed. TRIAL REGISTRATION:
      J.nr. 2005-54-1781 in Danish Data Protection Agency. J.nr. 07 268136 in
      Scientific Ethical Committee for Copenhagen and Frederiksberg Municipalities.
FAU - Tonnesen, Hanne
AU  - Tonnesen H
AD  - WHO-CC, Bispebjerg University Hospital, Bispebjerg Bakke 23, Copenhagen, DK-2400 
      KBH NV, Denmark. hanne.tonnesen@bbh.regionh.dk
FAU - Faurschou, Pernille
AU  - Faurschou P
FAU - Ralov, Helge
AU  - Ralov H
FAU - Molgaard-Nielsen, Ditte
AU  - Molgaard-Nielsen D
FAU - Thomas, Grethe
AU  - Thomas G
FAU - Backer, Vibeke
AU  - Backer V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100512
PL  - England
TA  - BMC Health Serv Res
JT  - BMC health services research
JID - 101088677
SB  - IM
MH  - Alcohol Drinking/*prevention & control
MH  - Family Practice
MH  - Female
MH  - Humans
MH  - Male
MH  - Physician's Role
MH  - *Preoperative Care
MH  - *Primary Health Care
MH  - Prospective Studies
MH  - Referral and Consultation/statistics & numerical data
MH  - Risk
MH  - Role
MH  - *Smoking Cessation
PMC - PMC2882918
EDAT- 2010/05/14 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/05/14 06:00
PHST- 2009/09/07 00:00 [received]
PHST- 2010/05/12 00:00 [accepted]
PHST- 2010/05/14 06:00 [entrez]
PHST- 2010/05/14 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - 1472-6963-10-121 [pii]
AID - 10.1186/1472-6963-10-121 [doi]
PST - epublish
SO  - BMC Health Serv Res. 2010 May 12;10:121. doi: 10.1186/1472-6963-10-121.


PMID- 20461642
OWN - NLM
STAT- MEDLINE
DCOM- 20100531
LR  - 20100512
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 5
DP  - 2010 May
TI  - Tweeting science and ethics: social media as a tool for constructive public
      engagement.
PG  - 30-1
LID - 10.1080/15265161003743497 [doi]
FAU - Regenberg, Alan C
AU  - Regenberg AC
AD  - Johns Hopkins Berman Institute of Bioethics, Baltimore, MD 21205, USA.
      aregenbe@jhsph.edu
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2010 May;10(5):16-23. PMID: 20461637
MH  - Bioethical Issues
MH  - *Communications Media/economics
MH  - Humans
MH  - Information Dissemination/*methods
MH  - *Internet/economics
MH  - *Medical Tourism
MH  - *Social Support
MH  - *Stem Cell Transplantation/ethics
EDAT- 2010/05/13 06:00
MHDA- 2010/06/01 06:00
CRDT- 2010/05/13 06:00
PHST- 2010/05/13 06:00 [entrez]
PHST- 2010/05/13 06:00 [pubmed]
PHST- 2010/06/01 06:00 [medline]
AID - 922104550 [pii]
AID - 10.1080/15265161003743497 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 May;10(5):30-1. doi: 10.1080/15265161003743497.


PMID- 20461638
OWN - NLM
STAT- MEDLINE
DCOM- 20100531
LR  - 20100512
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 5
DP  - 2010 May
TI  - Hope, hype and help: ethically assessing the growing market in stem cell
      therapies.
PG  - 24-5
LID - 10.1080/15265161.2010.481980 [doi]
FAU - Caplan, Arthur
AU  - Caplan A
AD  - The University of Pennsylvania, Department of Medical Ethics, 3401 Market Street,
      Philadelphia, PA 19104, USA. caplan@email.med.upenn.edu
FAU - Levine, Bruce
AU  - Levine B
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2010 May;10(5):16-23. PMID: 20461637
MH  - Canada
MH  - Emotions
MH  - European Union
MH  - Fraud
MH  - Humans
MH  - *International Cooperation
MH  - Internet
MH  - Japan
MH  - *Marketing of Health Services
MH  - *Medical Tourism
MH  - Minors
MH  - *Motivation
MH  - Patient Advocacy
MH  - Personal Autonomy
MH  - Societies, Medical
MH  - *Stem Cell Transplantation
MH  - United States
MH  - World Health Organization
EDAT- 2010/05/13 06:00
MHDA- 2010/06/01 06:00
CRDT- 2010/05/13 06:00
PHST- 2010/05/13 06:00 [entrez]
PHST- 2010/05/13 06:00 [pubmed]
PHST- 2010/06/01 06:00 [medline]
AID - 922106604 [pii]
AID - 10.1080/15265161.2010.481980 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 May;10(5):24-5. doi: 10.1080/15265161.2010.481980.


PMID- 20461637
OWN - NLM
STAT- MEDLINE
DCOM- 20100531
LR  - 20100512
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 5
DP  - 2010 May
TI  - Stem cell tourism and the power of hope.
PG  - 16-23
LID - 10.1080/15265161003728860 [doi]
AB  - This paper explores the notions of hope and how individual patient autonomy can
      trump carefully reasoned ethical concerns and policies intended to regulate stem 
      cell transplants. We argue that the same limits of knowledge that inform
      arguments to restrain and regulate unproven treatments might also undermine our
      ability to comprehensively dismiss or condemn them. Incautiously or
      indiscriminately reasoned policies and attitudes may drive critical information
      and data underground, impel patients away from working with clinical researchers,
      and tread needlessly on hope, the essential motivator of patients, advocates and 
      researchers alike. We offer recommendations to clinicians and health care
      providers to help balance the discourse with individuals seeking treatment while 
      guarding against fraud, misconception, and patient harm.
FAU - Murdoch, Charles E
AU  - Murdoch CE
AD  - Center for Law and the Biosciences, Stanford University, USA.
FAU - Scott, Christopher Thomas
AU  - Scott CT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CIN - Am J Bioeth. 2010 May;10(5):W1-3. PMID: 20461635
CIN - Am J Bioeth. 2010 May;10(5):24-5. PMID: 20461638
CIN - Am J Bioeth. 2010 May;10(5):26-7. PMID: 20461639
CIN - Am J Bioeth. 2010 May;10(5):30-1. PMID: 20461642
CIN - Am J Bioeth. 2010 May;10(5):31-2. PMID: 20461643
CIN - Am J Bioeth. 2010 May;10(5):33-4. PMID: 20461644
CIN - Am J Bioeth. 2010 May;10(5):34-6. PMID: 20461645
CIN - Am J Bioeth. 2010 May;10(5):38-40. PMID: 20461647
CIN - Am J Bioeth. 2010 May;10(5):40-2. PMID: 20461648
CIN - Am J Bioeth. 2010 May;10(5):43-5. PMID: 20461649
CIN - Am J Bioeth. 2010 May;10(5):45-6. PMID: 20461650
CIN - Am J Bioeth. 2010 May;10(5):47-8. PMID: 20461651
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Consensus
MH  - *Emotions
MH  - Humans
MH  - *Medical Tourism
MH  - Middle Aged
MH  - *Minors
MH  - *Motivation
MH  - Patient Advocacy
MH  - *Personal Autonomy
MH  - Professional Autonomy
MH  - *Stem Cell Transplantation/psychology
MH  - Therapeutic Misconception
MH  - Truth Disclosure
EDAT- 2010/05/13 06:00
MHDA- 2010/06/01 06:00
CRDT- 2010/05/13 06:00
PHST- 2010/05/13 06:00 [entrez]
PHST- 2010/05/13 06:00 [pubmed]
PHST- 2010/06/01 06:00 [medline]
AID - 922107262 [pii]
AID - 10.1080/15265161003728860 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 May;10(5):16-23. doi: 10.1080/15265161003728860.


PMID- 20461619
OWN - NLM
STAT- MEDLINE
DCOM- 20110314
LR  - 20100512
IS  - 1540-4048 (Electronic)
IS  - 0163-4372 (Linking)
VI  - 53
IP  - 4
DP  - 2010 May
TI  - Enhancing student gerocompetencies: evaluation of an intergenerational service
      learning course.
PG  - 319-35
LID - 10.1080/01634371003715577 [doi]
AB  - This article describes the development and evaluation of an intergenerational
      service-learning course designed to promote social work gerocompetencies.
      Service-learning opportunities were structured into the course, including an
      optional evidence-based falls prevention program, for older adults, entitled A
      Matter of Balance (MOB). Significant differences between pre- and posttest scores
      on the Geriatric Social Work Competency Scale (GSWCS) were noted for students in 
      the service learning course (n=13). Once MOB was introduced as an independent
      variable, the MOB participants scored the highest mean posttest scores for 2
      GSWCS domains: values, ethics, and theoretical perspectives; and intervention.
      The benefits of utilizing social work gerocompetencies to guide course
      objectives, content, and student outcomes are discussed.
FAU - Dauenhauer, Jason A
AU  - Dauenhauer JA
AD  - Department of Social Work, College at Brockport, State University of New York,
      Brockport, New York 14420, USA. jdauenha@brockport.edu
FAU - Steitz, David W
AU  - Steitz DW
FAU - Aponte, Carmen I
AU  - Aponte CI
FAU - Fromm Faria, Debra
AU  - Fromm Faria D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Gerontol Soc Work
JT  - Journal of gerontological social work
JID - 7903311
SB  - IM
MH  - Adult
MH  - Attitude of Health Personnel
MH  - Education/*methods
MH  - Educational Measurement
MH  - Evaluation Studies as Topic
MH  - Female
MH  - Geriatrics/*education
MH  - Humans
MH  - *Intergenerational Relations
MH  - Middle Aged
MH  - Problem-Based Learning
MH  - Program Evaluation
MH  - Social Work/*education
MH  - Students, Health Occupations/*psychology
EDAT- 2010/05/13 06:00
MHDA- 2011/03/15 06:00
CRDT- 2010/05/13 06:00
PHST- 2010/05/13 06:00 [entrez]
PHST- 2010/05/13 06:00 [pubmed]
PHST- 2011/03/15 06:00 [medline]
AID - 922105118 [pii]
AID - 10.1080/01634371003715577 [doi]
PST - ppublish
SO  - J Gerontol Soc Work. 2010 May;53(4):319-35. doi: 10.1080/01634371003715577.


PMID- 20461598
OWN - NLM
STAT- MEDLINE
DCOM- 20100920
LR  - 20211203
IS  - 1465-3419 (Electronic)
IS  - 1355-7858 (Linking)
VI  - 15
IP  - 3
DP  - 2010 Jun
TI  - Rangatiratanga and Oritetanga: responses to the Treaty of Waitangi in a New
      Zealand study.
PG  - 303-16
LID - 10.1080/13557851003721194 [doi]
AB  - INTRODUCTION: Although opportunities exist for positive experiences in research, 
      Maori in New Zealand, like other indigenous people colonised by Europeans in the 
      nineteenth century, have also been subject to research and associated policies
      that have had long-lasting negative consequences. Researchers have subsequently
      been challenged by Maori to conduct research that is acceptable, accountable and 
      relevant. Much of this debate has taken place within the framework of the Treaty 
      of Waitangi, a treaty of cession signed between Maori and British Crown
      representatives in 1840. Nowadays, health and health research statutes exist that
      require researchers to respond to the 'principles' of the Treaty. Few practical
      examples of how health researchers have undertaken this have been published.
      AIMS: We examine how, in developing a national study of injury outcomes, we
      responded to the Treaty. Our study, the Prospective Outcomes of Injury Study,
      aims to quantitatively identify predictors of disability following injury and to 
      qualitatively explore experiences and perceptions of injury outcomes. DISCUSSION:
      Responses to the Treaty included: consultation with Maori groups, translation of 
      the questionnaire into te reo Maori, appointment of interviewers fluent in te reo
      Maori, sufficient numbers of Maori participants to allow Maori-specific analyses 
      and the inclusion of a Maori-specific qualitative component. While this article
      is located within the New Zealand context, we believe it will resonate with, and 
      be of relevance to, health researchers in other former settler societies. We do
      not contend this project represents an 'ideal' model for undertaking
      population-based research. Instead, we hope that by describing our efforts at
      responding to the Treaty, we can prompt wider debate of the complex realities of 
      the research environment, one which is scientifically, ethically and culturally
      located.
FAU - Wyeth, Emma H
AU  - Wyeth EH
AD  - Te Roopu Rangahau Hauora Maori a Ngai Tahu (Ngai Tahu Maori Health Research
      Unit), Department of Preventive and Social Medicine, University of Otago,
      Dunedin, New Zealand. emma.wyeth@otago.ac.nz
FAU - Derrett, Sarah
AU  - Derrett S
FAU - Hokowhitu, Brendan
AU  - Hokowhitu B
FAU - Hall, Craig
AU  - Hall C
FAU - Langley, John
AU  - Langley J
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Ethn Health
JT  - Ethnicity & health
JID - 9608374
SB  - IM
MH  - Health Services, Indigenous/ethics/*history/*legislation & jurisprudence
MH  - *Healthcare Disparities
MH  - History, 19th Century
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - *International Cooperation
MH  - *Native Hawaiian or Other Pacific Islander
MH  - New Zealand
MH  - Outcome Assessment, Health Care
MH  - Research
MH  - Wounds and Injuries
EDAT- 2010/05/13 06:00
MHDA- 2010/09/21 06:00
CRDT- 2010/05/13 06:00
PHST- 2010/05/13 06:00 [entrez]
PHST- 2010/05/13 06:00 [pubmed]
PHST- 2010/09/21 06:00 [medline]
AID - 922086743 [pii]
AID - 10.1080/13557851003721194 [doi]
PST - ppublish
SO  - Ethn Health. 2010 Jun;15(3):303-16. doi: 10.1080/13557851003721194.


PMID- 20461569
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20100512
IS  - 1545-5815 (Electronic)
IS  - 0898-9621 (Linking)
VI  - 17
IP  - 3
DP  - 2010 May
TI  - Quality and peer review of research: an adjudicating role for editors.
PG  - 130-45
LID - 10.1080/08989621003791945 [doi]
AB  - Peer review gives research a stamp of approval, but the reviews themselves can be
      flawed. This is potentially serious for the writer, the journal, and journal
      user. This study describes shortcomings of the peer review process and condenses 
      them into an explanatory framework involving situational, personal, social, and
      ethical factors. Some proposals to improve matters are impractical and may make
      them worse. Some data is offered which illustrates the problem and suggests a
      potential solution. Informed editors who avoid mechanical approaches engage
      cautiously and critically with reviews and guard against bias, even in
      themselves, could make a significant difference.
FAU - Newton, Douglas P
AU  - Newton DP
AD  - School of Education, Durham University, Durham, England, UK.
      D.P.Newton@durham.ac.uk
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Account Res
JT  - Accountability in research
JID - 9100813
SB  - IM
MH  - Biomedical Research/*standards
MH  - Decision Making/ethics
MH  - *Editorial Policies
MH  - *Ethics, Research
MH  - Humans
MH  - Peer Review, Research/ethics/methods/*standards
MH  - Periodicals as Topic/*standards
MH  - Quality Control
EDAT- 2010/05/13 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/05/13 06:00
PHST- 2010/05/13 06:00 [entrez]
PHST- 2010/05/13 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - 922125037 [pii]
AID - 10.1080/08989621003791945 [doi]
PST - ppublish
SO  - Account Res. 2010 May;17(3):130-45. doi: 10.1080/08989621003791945.


PMID- 20461568
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20100512
IS  - 1545-5815 (Electronic)
IS  - 0898-9621 (Linking)
VI  - 17
IP  - 3
DP  - 2010 May
TI  - To tell or not to tell? The ethical dilemma of the would-be whistleblower.
PG  - 115-29
LID - 10.1080/08989621003791929 [doi]
AB  - Despite the growing emphasis placed on the responsible conduct of research,
      little attention has been devoted to the question of what an individual should do
      upon discovering research misconduct. This article takes seriously the dilemma of
      a would-be whistleblower. It identifies ethical considerations that can be taken 
      into account in moral decision-making about reporting research misconduct. It
      also offers rough guidelines about the moral significance of each consideration
      in the decision-making process based on the facts of the case in question. The
      article, therefore, offers tools for a would-be whistleblower to use to arrive at
      a defensible resolution to a difficult dilemma.
FAU - Malek, Janet
AU  - Malek J
AD  - Department of Medical Humanities, Brody School of Medicine, East Carolina
      University, Greenville, North Carolina 27834, USA. malekj@ecu.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Account Res
JT  - Accountability in research
JID - 9100813
SB  - IM
MH  - Decision Making/*ethics
MH  - *Ethics, Research
MH  - Humans
MH  - *Morals
MH  - Personnel Loyalty
MH  - Professional Role
MH  - Research Personnel/ethics
MH  - Scientific Misconduct/*ethics
MH  - Social Responsibility
MH  - United States
MH  - Whistleblowing/*ethics/legislation & jurisprudence
EDAT- 2010/05/13 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/05/13 06:00
PHST- 2010/05/13 06:00 [entrez]
PHST- 2010/05/13 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - 922125002 [pii]
AID - 10.1080/08989621003791929 [doi]
PST - ppublish
SO  - Account Res. 2010 May;17(3):115-29. doi: 10.1080/08989621003791929.


PMID- 20461363
OWN - NLM
STAT- MEDLINE
DCOM- 20100922
LR  - 20211020
IS  - 1432-1041 (Electronic)
IS  - 0031-6970 (Linking)
VI  - 66
IP  - 7
DP  - 2010 Jul
TI  - Healthy volunteers and early phases of clinical experimentation.
PG  - 647-53
LID - 10.1007/s00228-010-0827-0 [doi]
AB  - The main goal of early phase trials is to gain knowledge about the clinical
      suitability of novel compounds, without pursuing specific therapeutic purposes.
      Healthy volunteers usually represent the ideal model for conducting phase I
      clinical trials, in order to investigate pharmacokinetics and pharmacodynamics as
      well as to document safety and tolerability without interference by concomitant
      pathological conditions. The increasing cost of novel drug development, in
      conjunction with ethical considerations, has fostered a new procedure for
      first-in-man trials, designated as "phase 0," which is conducted very early on a 
      limited number of healthy volunteers who are exposed to low drug levels. The
      present review discusses issues concerning the enrollment of healthy volunteers
      in the early phase of drug development from different points of view, with some
      focus on the Italian experience. From the ethical standpoint, much discussion
      revolves around payments to healthy volunteers. Most authors agree that an
      adequate remuneration must be provided to healthy subjects, while avoiding
      coercion and excessive psychological pressure. Pending the lack of international 
      and national guidelines, our center for clinical drug experimentation has
      implemented an operative procedure to estimate payments for healthy volunteers
      based on specific items, including restriction, time spent, discomfort, and risk.
      Other unresolved issues about the recruitment of healthy volunteers are
      represented by the lack of international consensus on the definition of healthy
      status and the need for guidelines about advertisement on clinical trials
      addressed to potential participants.
FAU - Pasqualetti, Giuseppe
AU  - Pasqualetti G
AD  - Clinical Pharmacology Centre for Drug Experimentation Pisa University Hospital,
      Via Roma 67, 56100, Pisa, Italy.
FAU - Gori, Giovanni
AU  - Gori G
FAU - Blandizzi, Corrado
AU  - Blandizzi C
FAU - Del Tacca, Mario
AU  - Del Tacca M
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100512
PL  - Germany
TA  - Eur J Clin Pharmacol
JT  - European journal of clinical pharmacology
JID - 1256165
SB  - IM
MH  - Clinical Trials as Topic/economics/ethics/*methods
MH  - Guidelines as Topic
MH  - *Health Status
MH  - Humans
MH  - Patient Selection/*ethics
MH  - Research Subjects/*economics
RF  - 32
EDAT- 2010/05/13 06:00
MHDA- 2010/09/24 06:00
CRDT- 2010/05/13 06:00
PHST- 2010/01/19 00:00 [received]
PHST- 2010/04/01 00:00 [accepted]
PHST- 2010/05/13 06:00 [entrez]
PHST- 2010/05/13 06:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
AID - 10.1007/s00228-010-0827-0 [doi]
PST - ppublish
SO  - Eur J Clin Pharmacol. 2010 Jul;66(7):647-53. doi: 10.1007/s00228-010-0827-0. Epub
      2010 May 12.


PMID- 20460612
OWN - NLM
STAT- MEDLINE
DCOM- 20100512
LR  - 20161017
IS  - 1538-3598 (Electronic)
IS  - 0098-7484 (Linking)
VI  - 303
IP  - 18
DP  - 2010 May 12
TI  - Reports promote high standards for ethical conduct of pediatric clinical trials.
PG  - 1800
LID - 10.1001/jama.2010.579 [doi]
FAU - Kuehn, Bridget M
AU  - Kuehn BM
LA  - eng
PT  - News
PL  - United States
TA  - JAMA
JT  - JAMA
JID - 7501160
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Clinical Trials as Topic/*ethics
MH  - Conflict of Interest
MH  - Decision Making
MH  - *Guidelines as Topic
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Societies, Medical
EDAT- 2010/05/13 06:00
MHDA- 2010/05/13 06:01
CRDT- 2010/05/13 06:00
PHST- 2010/05/13 06:00 [entrez]
PHST- 2010/05/13 06:00 [pubmed]
PHST- 2010/05/13 06:01 [medline]
AID - 303/18/1800 [pii]
AID - 10.1001/jama.2010.579 [doi]
PST - ppublish
SO  - JAMA. 2010 May 12;303(18):1800. doi: 10.1001/jama.2010.579.


PMID- 20460294
OWN - NLM
STAT- MEDLINE
DCOM- 20110209
LR  - 20161020
IS  - 1941-2479 (Electronic)
IS  - 1010-5395 (Linking)
VI  - 22
IP  - 3
DP  - 2010 Jul
TI  - Review paper: Organ transplants: ethical, social, and religious issues in a
      multicultural society.
PG  - 271-8
LID - 10.1177/1010539509357446 [doi]
AB  - Recent advances in the fields of organ donation and organ transplant have
      introduced new hope for the treatment of serious diseases. However, this promise 
      has been accompanied by several issues. The most common issue raised is ethical
      implications, but in a multicultural society like Malaysia, additional concerns
      arise pertaining to social and religious issues. These concerns needs to be
      addressed as attitudes toward and acceptability of organ donation varies
      according to social, culture, and religion. The diverse cultural, religious, and 
      traditional concepts pertaining to organ donation may hamper its acceptability
      and cause a lack of willingness to donate organs. The purpose of this article is 
      to briefly explore the ethical issues involved in organ transplant and the
      various religious opinions on organ donation. It is hoped that this knowledge and
      understanding may benefit both health care providers and patients in a
      multicultural society like Malaysia.
FAU - Robson, Noor Zurani Md Haris
AU  - Robson NZ
AD  - University of Malaya, Kuala Lumpur, Malaysia. noorzurani@hotmail.com
FAU - Razack, Azad Hassan
AU  - Razack AH
FAU - Dublin, Norman
AU  - Dublin N
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100510
PL  - China
TA  - Asia Pac J Public Health
JT  - Asia-Pacific journal of public health
JID - 8708538
SB  - IM
MH  - Attitude to Health
MH  - *Cultural Characteristics
MH  - Cultural Diversity
MH  - Humans
MH  - Malaysia
MH  - Organ Transplantation/*ethics
MH  - *Religion and Medicine
MH  - Tissue and Organ Procurement/*ethics
EDAT- 2010/05/13 06:00
MHDA- 2011/02/10 06:00
CRDT- 2010/05/13 06:00
PHST- 2010/05/13 06:00 [entrez]
PHST- 2010/05/13 06:00 [pubmed]
PHST- 2011/02/10 06:00 [medline]
AID - 1010539509357446 [pii]
AID - 10.1177/1010539509357446 [doi]
PST - ppublish
SO  - Asia Pac J Public Health. 2010 Jul;22(3):271-8. doi: 10.1177/1010539509357446.
      Epub 2010 May 10.


PMID- 20459835
OWN - NLM
STAT- MEDLINE
DCOM- 20110613
LR  - 20211020
IS  - 1747-5341 (Electronic)
IS  - 1747-5341 (Linking)
VI  - 5
DP  - 2010 May 11
TI  - Should the NHS be privatized? Annual varsity medical debate - London, 22 January 
      2010.
PG  - 7
LID - 10.1186/1747-5341-5-7 [doi]
AB  - The Varsity Medical Debate, between Oxford and Cambridge Universities, brings
      together practitioners and the public, professors, pupils and members of the
      polis, to facilitate discussion about ethics and policy within healthcare. The
      motion on privatizing the National Health Service (NHS) was specifically chosen
      to reflect the growing sentiment in the UK where further discourse upon models of
      healthcare was required. Time and again, the outcome of British elections pivots 
      upon the topic of financial sustainability of the NHS. Having recently celebrated
      its sixtieth anniversary, the NHS has become heavily politicized in recent
      months, especially in the aftermath of the devastating global recession.
FAU - Nagendran, Myura
AU  - Nagendran M
AD  - University of Cambridge, UK. mn337@cam.ac.uk
FAU - Budhdeo, Sanjay
AU  - Budhdeo S
FAU - Maruthappu, Mahiben
AU  - Maruthappu M
FAU - Sugand, Kapil
AU  - Sugand K
LA  - eng
PT  - Journal Article
DEP - 20100511
PL  - England
TA  - Philos Ethics Humanit Med
JT  - Philosophy, ethics, and humanities in medicine : PEHM
JID - 101258058
SB  - IM
MH  - Delivery of Health Care/organization & administration
MH  - *Dissent and Disputes
MH  - *Ethics, Medical
MH  - *Health Policy
MH  - Humans
MH  - Models, Organizational
MH  - Politics
MH  - Private Sector/*legislation & jurisprudence
MH  - Public Sector/*legislation & jurisprudence
MH  - State Medicine/legislation & jurisprudence/*organization & administration
MH  - United Kingdom
PMC - PMC2878290
EDAT- 2010/05/13 06:00
MHDA- 2011/06/15 06:00
CRDT- 2010/05/13 06:00
PHST- 2010/02/17 00:00 [received]
PHST- 2010/05/11 00:00 [accepted]
PHST- 2010/05/13 06:00 [entrez]
PHST- 2010/05/13 06:00 [pubmed]
PHST- 2011/06/15 06:00 [medline]
AID - 1747-5341-5-7 [pii]
AID - 10.1186/1747-5341-5-7 [doi]
PST - epublish
SO  - Philos Ethics Humanit Med. 2010 May 11;5:7. doi: 10.1186/1747-5341-5-7.


PMID- 20458522
OWN - NLM
STAT- MEDLINE
DCOM- 20100928
LR  - 20211020
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 22
IP  - 1
DP  - 2010 Mar
TI  - Exploring a model role description for ethicists.
PG  - 31-40
LID - 10.1007/s10730-010-9126-5 [doi]
AB  - This paper provides a description of the role of the clinical ethicist as it is
      generally experienced in Canada. It examines the activities of Canadian ethicists
      working in healthcare institutions and the way in which their work incorporates
      more than ethics case consultation. The Canadian Bioethics Society established a 
      "Taskforce on Working Conditions for Bioethics" (hereafter referred to as the
      Taskforce), to make recommendations on a number of issues affecting ethicists and
      to develop a model role description. This essay carefully assesses this model
      role description.
FAU - Chidwick, Paula
AU  - Chidwick P
AD  - Brampton Civic Hospital, ON, Canada. PAULA.CHIDWICK@williamoslerhs.ca
FAU - Bell, Jennifer
AU  - Bell J
FAU - Connolly, Eoin
AU  - Connolly E
FAU - Coughlin, Michael D
AU  - Coughlin MD
FAU - Frolic, Andrea
AU  - Frolic A
FAU - Hardingham, Laurie
AU  - Hardingham L
FAU - Zlotnik Shaul, Randi
AU  - Zlotnik Shaul R
CN  - Canadian Bioethics Society Taskforce on Working Conditions for Bioethics
LA  - eng
PT  - Consensus Development Conference
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - Canada
MH  - *Ethicists/education
MH  - *Ethics Consultation/organization & administration
MH  - Humans
MH  - *Job Description
MH  - *Professional Role
MH  - Task Performance and Analysis
RF  - 13
EDAT- 2010/05/12 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/05/12 06:00
PHST- 2010/05/12 06:00 [entrez]
PHST- 2010/05/12 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - 10.1007/s10730-010-9126-5 [doi]
PST - ppublish
SO  - HEC Forum. 2010 Mar;22(1):31-40. doi: 10.1007/s10730-010-9126-5.


PMID- 20458470
OWN - NLM
STAT- MEDLINE
DCOM- 20100920
LR  - 20191210
IS  - 1618-2650 (Electronic)
IS  - 1618-2642 (Linking)
VI  - 397
IP  - 5
DP  - 2010 Jul
TI  - Biological methods for marine toxin detection.
PG  - 1673-81
LID - 10.1007/s00216-010-3782-9 [doi]
AB  - The presence of marine toxins in seafood poses a health risk to human consumers
      which has prompted the regulation of the maximum content of marine toxins in
      seafood in the legislations of many countries. Most marine toxin groups are
      detected by animal bioassays worldwide. Although this method has well known
      ethical and technical drawbacks, it is the official detection method for all
      regulated phycotoxins except domoic acid. Much effort by the scientific and
      regulatory communities has been focused on the development of alternative
      techniques that enable the substitution or reduction of bioassays; some of these 
      have recently been included in the official detection method list. During the
      last two decades several biological methods including use of biosensors have been
      adapted for detection of marine toxins. The main advances in marine toxin
      detection using this kind of technique are reviewed. Biological methods offer
      interesting possibilities for reduction of the number of biosassays and a very
      promising future of new developments.
FAU - Vilarino, Natalia
AU  - Vilarino N
AD  - Departamento de Farmacologia, Facultad de Veterinaria, Universidad de Santiago de
      Compostela, Campus Universitario, 27002, Lugo, Spain. Natalia.vilarino@usc.es
FAU - Louzao, M Carmen
AU  - Louzao MC
FAU - Vieytes, Mercedes R
AU  - Vieytes MR
FAU - Botana, Luis M
AU  - Botana LM
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Review
DEP - 20100512
PL  - Germany
TA  - Anal Bioanal Chem
JT  - Analytical and bioanalytical chemistry
JID - 101134327
RN  - 0 (Marine Toxins)
SB  - IM
MH  - Animals
MH  - Biological Assay/*methods
MH  - Humans
MH  - Marine Toxins/*analysis/toxicity
MH  - Seafood/*analysis
RF  - 94
EDAT- 2010/05/12 06:00
MHDA- 2010/09/21 06:00
CRDT- 2010/05/12 06:00
PHST- 2010/02/27 00:00 [received]
PHST- 2010/04/23 00:00 [accepted]
PHST- 2010/04/13 00:00 [revised]
PHST- 2010/05/12 06:00 [entrez]
PHST- 2010/05/12 06:00 [pubmed]
PHST- 2010/09/21 06:00 [medline]
AID - 10.1007/s00216-010-3782-9 [doi]
PST - ppublish
SO  - Anal Bioanal Chem. 2010 Jul;397(5):1673-81. doi: 10.1007/s00216-010-3782-9. Epub 
      2010 May 12.


PMID- 20458196
OWN - NLM
STAT- MEDLINE
DCOM- 20100518
LR  - 20151119
IS  - 1539-736X (Electronic)
IS  - 0022-3018 (Linking)
VI  - 198
IP  - 5
DP  - 2010 May
TI  - The subjective experience of participation in schizophrenia research: a practical
      and ethical issue.
PG  - 343-8
LID - 10.1097/NMD.0b013e3181da8545 [doi]
AB  - Mental health research may pose a risk to those who participate in it, especially
      for potentially vulnerable groups such as those diagnosed with schizophrenia. The
      current study aimed to investigate the subjective experience of research
      participation in this group. Seventy-nine individuals with diagnoses of
      schizophrenia spectrum disorders who had taken part in research looking at
      suicide were asked to provide feedback about their experiences. Responses were
      analyzed using qualitative and quantitative methods. Results indicate that
      negative feedback concerning participation was rare, occurring in 2.5% to 15.2%
      of responses. Positive feedback was more frequent, occurring in 45.6% to 60.8% of
      responses. Qualitative thematic analysis identified 5 key themes in participants'
      responses: Altruism, Value of being involved in research, Therapeutic effect,
      Enjoyable experience and Negative experiences. The results support the view that 
      mental health research in this group can be ethically viable.
FAU - Taylor, Peter James
AU  - Taylor PJ
AD  - School of Psychological Sciences, University of Manchester, Manchester, United
      Kingdom. p.j.taylor@postgrad.manchester.ac.uk
FAU - Awenat, Yvonne
AU  - Awenat Y
FAU - Gooding, Patricia
AU  - Gooding P
FAU - Johnson, Judith
AU  - Johnson J
FAU - Pratt, Daniel
AU  - Pratt D
FAU - Wood, Alex
AU  - Wood A
FAU - Tarrier, Nicholas
AU  - Tarrier N
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Nerv Ment Dis
JT  - The Journal of nervous and mental disease
JID - 0375402
SB  - IM
MH  - Adult
MH  - Altruism
MH  - *Attitude
MH  - Attitude to Health
MH  - *Ethics, Research
MH  - Feedback
MH  - Female
MH  - Humans
MH  - Informed Consent
MH  - Male
MH  - Motivation
MH  - Patient Participation
MH  - Patient Satisfaction
MH  - Psychotic Disorders/*psychology
MH  - Qualitative Research
MH  - Research Subjects/*psychology
MH  - Researcher-Subject Relations/ethics/psychology
MH  - Schizophrenia/*diagnosis
MH  - *Schizophrenic Psychology
MH  - Suicide/prevention & control/psychology
MH  - *Surveys and Questionnaires
EDAT- 2010/05/12 06:00
MHDA- 2010/05/19 06:00
CRDT- 2010/05/12 06:00
PHST- 2010/05/12 06:00 [entrez]
PHST- 2010/05/12 06:00 [pubmed]
PHST- 2010/05/19 06:00 [medline]
AID - 10.1097/NMD.0b013e3181da8545 [doi]
AID - 00005053-201005000-00005 [pii]
PST - ppublish
SO  - J Nerv Ment Dis. 2010 May;198(5):343-8. doi: 10.1097/NMD.0b013e3181da8545.


PMID- 20458111
OWN - NLM
STAT- MEDLINE
DCOM- 20101005
LR  - 20211020
IS  - 1544-1717 (Electronic)
IS  - 1544-1709 (Linking)
VI  - 8
IP  - 3
DP  - 2010 May-Jun
TI  - Beneficent persuasion: techniques and ethical guidelines to improve patients'
      decisions.
PG  - 260-4
LID - 10.1370/afm.1118 [doi]
AB  - Physicians frequently encounter patients who make decisions that contravene their
      long-term goals. Behavioral economists have shown that irrationalities and
      self-thwarting tendencies pervade human decision making, and they have identified
      a number of specific heuristics (rules of thumb) and biases that help explain why
      patients sometimes make such counterproductive decisions. In this essay, we use
      clinical examples to describe the many ways in which these heuristics and biases 
      influence patients' decisions. We argue that physicians should develop their
      understanding of these potentially counterproductive decisional biases and, in
      many cases, use this knowledge to rebias their patients in ways that promote
      patients' health or other values. Using knowledge of decision-making psychology
      to persuade patients to engage in healthy behaviors or to make treatment
      decisions that foster their long-term goals is ethically justified by physicians'
      duties to promote their patients' interests and will often enhance, rather than
      limit, their patients' autonomy. We describe techniques that physicians may use
      to frame health decisions to patients in ways that are more likely to motivate
      patients to make choices that are less biased and more conducive to their
      long-term goals. Marketers have been using these methods for decades to get
      patients to engage in unhealthy behaviors; employers and policy makers are
      beginning to consider the use of similar approaches to influence healthy choices.
      It is time for clinicians also to make use of behavioral psychology in their
      interactions with patients.
FAU - Swindell, J S
AU  - Swindell JS
AD  - Center for Medical Ethics and Health Policy, Baylor College of Medicine, One
      Baylor Plaza, Houston, TX 77030-4311, USA. jsswinde@bcm.edu
FAU - McGuire, Amy L
AU  - McGuire AL
FAU - Halpern, Scott D
AU  - Halpern SD
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Fam Med
JT  - Annals of family medicine
JID - 101167762
SB  - IM
MH  - Bias
MH  - *Decision Making
MH  - *Directive Counseling
MH  - *Ethics, Medical
MH  - Health Behavior
MH  - Health Promotion
MH  - Humans
MH  - Informed Consent
MH  - Motivation
MH  - Patient Education as Topic/ethics
MH  - *Persuasive Communication
MH  - Physician-Patient Relations/*ethics
MH  - Physicians/psychology
MH  - Practice Guidelines as Topic
MH  - Professional Autonomy
PMC - PMC2866725
EDAT- 2010/05/12 06:00
MHDA- 2010/10/06 06:00
CRDT- 2010/05/12 06:00
PHST- 2010/05/12 06:00 [entrez]
PHST- 2010/05/12 06:00 [pubmed]
PHST- 2010/10/06 06:00 [medline]
AID - 8/3/260 [pii]
AID - 10.1370/afm.1118 [doi]
PST - ppublish
SO  - Ann Fam Med. 2010 May-Jun;8(3):260-4. doi: 10.1370/afm.1118.


PMID- 20458078
OWN - NLM
STAT- MEDLINE
DCOM- 20100701
LR  - 20151119
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Linking)
VI  - 74
IP  - 19
DP  - 2010 May 11
TI  - Responding to requests from adult patients for neuroenhancements: guidance of the
      ethics, law and humanities committee.
PG  - 1555-6; author reply 1556
LID - 10.1212/WNL.0b013e3181d8a54a [doi]
FAU - Racine, Eric
AU  - Racine E
FAU - Forlini, Cynthia
AU  - Forlini C
LA  - eng
PT  - Letter
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - 0 (Nootropic Agents)
SB  - IM
MH  - Adult
MH  - Advisory Committees/*ethics/standards
MH  - *Ethics, Medical
MH  - Evidence-Based Medicine/ethics/standards
MH  - Humans
MH  - Neurology/ethics
MH  - Neuropharmacology/*ethics
MH  - Nootropic Agents/adverse effects/*therapeutic use
MH  - Physician-Patient Relations/ethics
MH  - Practice Guidelines as Topic/*standards
MH  - Practice Patterns, Physicians'/ethics/standards
MH  - Prescriptions/standards
MH  - Risk Assessment
MH  - Societies, Medical/*ethics/standards
EDAT- 2010/05/12 06:00
MHDA- 2010/07/02 06:00
CRDT- 2010/05/12 06:00
PHST- 2010/05/12 06:00 [entrez]
PHST- 2010/05/12 06:00 [pubmed]
PHST- 2010/07/02 06:00 [medline]
AID - 74/19/1555 [pii]
AID - 10.1212/WNL.0b013e3181d8a54a [doi]
PST - ppublish
SO  - Neurology. 2010 May 11;74(19):1555-6; author reply 1556. doi:
      10.1212/WNL.0b013e3181d8a54a.


PMID- 20458029
OWN - NLM
STAT- MEDLINE
DCOM- 20110207
LR  - 20101109
IS  - 1527-7755 (Electronic)
IS  - 0732-183X (Linking)
VI  - 28
IP  - 32
DP  - 2010 Nov 10
TI  - Fertility preservation in adolescents and young adults with cancer.
PG  - 4831-41
LID - 10.1200/JCO.2009.22.8312 [doi]
AB  - Preservation of fertility is important to adolescent and young adult (AYA)
      survivors of cancer. Many survivors will maintain their reproductive potential
      after the successful completion of treatment for cancer. However total-body
      irradiation, radiation to the gonads, and chemotherapy regimens containing
      high-dose alkylators can place women at risk for acute ovarian failure or
      premature menopause and men at risk for temporary or permanent azoospermia. The
      most effective and established means of preserving fertility in this population
      is embryo cryopreservation in women and sperm cryopreservation in men before the 
      initiation of cancer-directed therapy. Cryopreservation of mature oocytes is also
      becoming more commonplace as methods of thawing become more sophisticated. The
      use of in vitro fertilization and intracytoplasmic sperm injection has added to
      the viability of sperm and oocyte cryopreservation. Cryopreservation and
      transplantation of gonadal tissue in both males and females remains experimental 
      but continues to be evaluated. Hormonal suppression has not been shown to be
      effective in males but may have promise in females, although larger scale trials 
      are needed to evaluate this. Providing information about risk of infertility and 
      possible interventions to maintain reproductive potential are critical for the
      AYA population at the time of diagnosis. Given the competing demands of providing
      complicated and detailed information about cancer treatment, the evolving
      information related to fertility preservation, and the ethical issues involved,
      it may be preferable, where possible, to have a specialized team, rather than the
      primary oncologist, address these issues with AYA patients.
FAU - Levine, Jennifer
AU  - Levine J
AD  - Division of Pediatric Oncology, Columbia University Medical Center, New York, NY 
      10032, USA. jl175@columbia.edu
FAU - Canada, Andrea
AU  - Canada A
FAU - Stern, Catharyn J
AU  - Stern CJ
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100510
PL  - United States
TA  - J Clin Oncol
JT  - Journal of clinical oncology : official journal of the American Society of
      Clinical Oncology
JID - 8309333
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Adolescent
MH  - Antineoplastic Agents/adverse effects
MH  - Attitude to Health
MH  - Female
MH  - *Fertility
MH  - Humans
MH  - Male
MH  - Neoplasms/psychology/*therapy
MH  - Ovum
MH  - Radiotherapy/adverse effects
MH  - Semen Preservation
MH  - Tissue Preservation
MH  - Young Adult
EDAT- 2010/05/12 06:00
MHDA- 2011/02/08 06:00
CRDT- 2010/05/12 06:00
PHST- 2010/05/12 06:00 [entrez]
PHST- 2010/05/12 06:00 [pubmed]
PHST- 2011/02/08 06:00 [medline]
AID - JCO.2009.22.8312 [pii]
AID - 10.1200/JCO.2009.22.8312 [doi]
PST - ppublish
SO  - J Clin Oncol. 2010 Nov 10;28(32):4831-41. doi: 10.1200/JCO.2009.22.8312. Epub
      2010 May 10.


PMID- 20457776
OWN - NLM
STAT- MEDLINE
DCOM- 20100922
LR  - 20211020
IS  - 1488-2329 (Electronic)
IS  - 0820-3946 (Linking)
VI  - 182
IP  - 9
DP  - 2010 Jun 15
TI  - Research ethics council faces dissolution.
PG  - 890
LID - 10.1503/cmaj.109-3254 [doi]
FAU - Shuchman, Miriam
AU  - Shuchman M
LA  - eng
PT  - News
DEP - 20100510
PL  - Canada
TA  - CMAJ
JT  - CMAJ : Canadian Medical Association journal = journal de l'Association medicale
      canadienne
JID - 9711805
SB  - IM
MH  - Canada
MH  - *Ethics Committees, Research/organization & administration
MH  - Ethics, Research
MH  - Humans
PMC - PMC2882448
EDAT- 2010/05/12 06:00
MHDA- 2010/09/24 06:00
CRDT- 2010/05/12 06:00
PHST- 2010/05/12 06:00 [entrez]
PHST- 2010/05/12 06:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
AID - cmaj.109-3254 [pii]
AID - 10.1503/cmaj.109-3254 [doi]
PST - ppublish
SO  - CMAJ. 2010 Jun 15;182(9):890. doi: 10.1503/cmaj.109-3254. Epub 2010 May 10.


PMID- 20457662
OWN - NLM
STAT- MEDLINE
DCOM- 20110120
LR  - 20141120
IS  - 1471-8391 (Electronic)
IS  - 0007-1420 (Linking)
VI  - 95
DP  - 2010
TI  - Policy strategies to reduce waits for elective care: a synthesis of international
      evidence.
PG  - 7-32
LID - 10.1093/bmb/ldq014 [doi]
AB  - This synthesis seeks to assess and explain the effectiveness of policy
      interventions to reduce elective wait times or lists. PubMed, EMBASE, EconLit,
      and grey literature were systematically searched for relevant studies and
      reviews. Strategies with the strongest evidence base include paying for activity,
      buying capacity locally and setting targets with strong incentives. There is also
      evidence for improving the use of existing capacity. Limiting demand through
      rationing can reduce waits, but is ethically problematic. Short-term injections
      of funding, cross-border treatment schemes, unenforced targets and promotion of
      private health insurance had the weakest evidence. Available evidence favours
      options that act fairly directly on supply, demand or local organizations'
      behaviour, over indirect strategies that depend on a 'domino effect'. Further
      research is needed to determine how to achieve major, system-wide improvements in
      the use of capacity.
FAU - Kreindler, Sara A
AU  - Kreindler SA
AD  - Department of Community Health Sciences, Winnipeg Regional Health Authority,
      Research and Evaluation Unit, and University of Manitoba, Winnipeg, Manitoba,
      Canada. skreindler@wrha.mb.ca
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100510
PL  - England
TA  - Br Med Bull
JT  - British medical bulletin
JID - 0376542
SB  - IM
MH  - Efficiency, Organizational/economics/standards
MH  - Elective Surgical Procedures/economics
MH  - Evidence-Based Medicine
MH  - *Health Policy
MH  - Health Services Needs and Demand/economics/*standards
MH  - Humans
MH  - Public Health Administration/economics/*standards
MH  - Time Factors
MH  - *Waiting Lists
EDAT- 2010/05/12 06:00
MHDA- 2011/01/21 06:00
CRDT- 2010/05/12 06:00
PHST- 2010/05/12 06:00 [entrez]
PHST- 2010/05/12 06:00 [pubmed]
PHST- 2011/01/21 06:00 [medline]
AID - ldq014 [pii]
AID - 10.1093/bmb/ldq014 [doi]
PST - ppublish
SO  - Br Med Bull. 2010;95:7-32. doi: 10.1093/bmb/ldq014. Epub 2010 May 10.


PMID- 20457057
OWN - NLM
STAT- MEDLINE
DCOM- 20101230
LR  - 20100920
IS  - 1878-0326 (Electronic)
IS  - 1872-4973 (Linking)
VI  - 4
IP  - 5
DP  - 2010 Oct
TI  - Use of DNA profiles for investigation using a simulated national DNA database:
      Part II. Statistical and ethical considerations on familial searching.
PG  - 316-22
LID - 10.1016/j.fsigen.2009.11.006 [doi]
AB  - Familial searching consists of searching for a full profile left at a crime scene
      in a National DNA Database (NDNAD). In this paper we are interested in the
      circumstance where no full match is returned, but a partial match is found
      between a database member's profile and the crime stain. Because close relatives 
      share more of their DNA than unrelated persons, this partial match may indicate
      that the crime stain was left by a close relative of the person with whom the
      partial match was found. This approach has successfully solved important crimes
      in the UK and the USA. In a previous paper, a model, which takes into account
      substructure and siblings, was used to simulate a NDNAD. In this paper, we have
      used this model to test the usefulness of familial searching and offer guidelines
      for pre-assessment of the cases based on the likelihood ratio. Siblings of
      "persons" present in the simulated Swiss NDNAD were created. These profiles
      (N=10,000) were used as traces and were then compared to the whole database
      (N=100,000). The statistical results obtained show that the technique has great
      potential confirming the findings of previous studies. However, effectiveness of 
      the technique is only one part of the story. Familial searching has juridical and
      ethical aspects that should not be ignored. In Switzerland for example, there are
      no specific guidelines to the legality or otherwise of familial searching. This
      article both presents statistical results, and addresses criminological and civil
      liberties aspects to take into account risks and benefits of familial searching.
CI  - Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
FAU - Hicks, T
AU  - Hicks T
AD  - School of Criminal Justice, Institut de police scientifique, University of
      Lausanne, Batochime, 1015 Lausanne Dorigny, Switzerland.
      tacha.hickschampod@unil.ch
FAU - Taroni, F
AU  - Taroni F
FAU - Curran, J
AU  - Curran J
FAU - Buckleton, J
AU  - Buckleton J
FAU - Castella, V
AU  - Castella V
FAU - Ribaux, O
AU  - Ribaux O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100114
PL  - Netherlands
TA  - Forensic Sci Int Genet
JT  - Forensic science international. Genetics
JID - 101317016
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Alleles
MH  - DNA/*genetics
MH  - *Databases, Genetic
MH  - *Ethics
MH  - *Family
MH  - Humans
EDAT- 2010/05/12 06:00
MHDA- 2010/12/31 06:00
CRDT- 2010/05/12 06:00
PHST- 2009/02/24 00:00 [received]
PHST- 2009/08/31 00:00 [revised]
PHST- 2009/11/27 00:00 [accepted]
PHST- 2010/05/12 06:00 [entrez]
PHST- 2010/05/12 06:00 [pubmed]
PHST- 2010/12/31 06:00 [medline]
AID - S1872-4973(09)00188-4 [pii]
AID - 10.1016/j.fsigen.2009.11.006 [doi]
PST - ppublish
SO  - Forensic Sci Int Genet. 2010 Oct;4(5):316-22. doi: 10.1016/j.fsigen.2009.11.006. 
      Epub 2010 Jan 14.


PMID- 20457018
OWN - NLM
STAT- MEDLINE
DCOM- 20110126
LR  - 20110722
IS  - 1878-0539 (Electronic)
IS  - 1748-6815 (Linking)
VI  - 64
IP  - 1
DP  - 2011 Jan
TI  - Beneficence, non-maleficence, distributive justice and respect for patient
      autonomy--reconcilable ends in aesthetic surgery?
PG  - 11-6
LID - 10.1016/j.bjps.2010.03.034 [doi]
AB  - Respect for patient autonomy, as a fundamental principle in contemporary
      bioethics, guides the process of informed consent through which, it is hoped,
      patients' wishes are determined and executed. However, when procedures are
      exclusively cosmetic, questions as to the ethical legitimacy of such requests and
      enhancements arise. The purpose of this article is a thorough evaluation of the
      notions of and tensions inherent to the practice of autonomy and informed consent
      as they apply in aesthetic surgery. The question of motivation to undergo
      enhancement will be discussed, as well as the significance of risk and competence
      in determining the legitimacy of choice. The final conclusion is that the
      complexity of the moral issues involved requires conceptualization of an expanded
      notion of responsibility, which recognises that we need to progress beyond a
      'legal' to a 'moral' conception. The implications of this expanded notion of
      responsibility are discussed.
CI  - Copyright (c) 2010 British Association of Plastic, Reconstructive and Aesthetic
      Surgeons. Published by Elsevier Ltd. All rights reserved.
FAU - De Roubaix, J A M
AU  - De Roubaix JA
AD  - Center for Applied Ethics, Department of Philosophy, University of Stellenbosch, 
      South Africa. malcolmderoubaix@gmail.com
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100424
PL  - Netherlands
TA  - J Plast Reconstr Aesthet Surg
JT  - Journal of plastic, reconstructive & aesthetic surgery : JPRAS
JID - 101264239
SB  - IM
CIN - J Plast Reconstr Aesthet Surg. 2011 Jul;64(7):978-9. PMID: 21306966
MH  - Bioethical Issues
MH  - Cultural Characteristics
MH  - Female
MH  - Humans
MH  - Informed Consent/*ethics/legislation & jurisprudence
MH  - Male
MH  - *Moral Obligations
MH  - *Personal Autonomy
MH  - Risk Assessment
MH  - South Africa
MH  - Surgery, Plastic/*ethics/legislation & jurisprudence
MH  - Total Quality Management
EDAT- 2010/05/12 06:00
MHDA- 2011/01/28 06:00
CRDT- 2010/05/12 06:00
PHST- 2010/01/26 00:00 [received]
PHST- 2010/03/11 00:00 [accepted]
PHST- 2010/05/12 06:00 [entrez]
PHST- 2010/05/12 06:00 [pubmed]
PHST- 2011/01/28 06:00 [medline]
AID - S1748-6815(10)00175-0 [pii]
AID - 10.1016/j.bjps.2010.03.034 [doi]
PST - ppublish
SO  - J Plast Reconstr Aesthet Surg. 2011 Jan;64(1):11-6. doi:
      10.1016/j.bjps.2010.03.034. Epub 2010 Apr 24.


PMID- 20456982
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20100712
IS  - 1557-3117 (Electronic)
IS  - 1053-2498 (Linking)
VI  - 29
IP  - 7
DP  - 2010 Jul
TI  - Ethical issues associated with globalization of placebo-controlled in pulmonary
      arterial hypertension.
PG  - 825-6
LID - 10.1016/j.healun.2010.03.010 [doi]
FAU - Farber, Harrison W
AU  - Farber HW
FAU - Walkey, Allan J
AU  - Walkey AJ
FAU - O'Donnell, Max R
AU  - O'Donnell MR
LA  - eng
PT  - Comment
PT  - Letter
DEP - 20100424
PL  - United States
TA  - J Heart Lung Transplant
JT  - The Journal of heart and lung transplantation : the official publication of the
      International Society for Heart Transplantation
JID - 9102703
RN  - 0 (Placebos)
RN  - 0 (Vasodilator Agents)
SB  - IM
CON - J Heart Lung Transplant. 2010 Feb;29(2):137-49. PMID: 20022264
CON - J Heart Lung Transplant. 2010 Feb;29(2):157-8. PMID: 20113908
CIN - J Heart Lung Transplant. 2010 Jul;29(7):827-8. PMID: 20417131
CIN - J Heart Lung Transplant. 2010 Jul;29(7):826-7. PMID: 20471863
MH  - Catheterization, Central Venous/adverse effects
MH  - Controlled Clinical Trials as Topic/*ethics
MH  - Developed Countries
MH  - Humans
MH  - Hypertension, Pulmonary/*drug therapy
MH  - *Internationality
MH  - Placebos/*therapeutic use
MH  - Vasodilator Agents/*therapeutic use
EDAT- 2010/05/12 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/05/12 06:00
PHST- 2010/02/16 00:00 [received]
PHST- 2010/03/17 00:00 [accepted]
PHST- 2010/05/12 06:00 [entrez]
PHST- 2010/05/12 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - S1053-2498(10)00202-0 [pii]
AID - 10.1016/j.healun.2010.03.010 [doi]
PST - ppublish
SO  - J Heart Lung Transplant. 2010 Jul;29(7):825-6. doi: 10.1016/j.healun.2010.03.010.
      Epub 2010 Apr 24.


PMID- 20456773
OWN - NLM
STAT- MEDLINE
DCOM- 20100607
LR  - 20101104
IS  - 1876-8784 (Electronic)
IS  - 0028-2162 (Linking)
VI  - 154
DP  - 2010
TI  - [Ethical case deliberations in the Neonatology Department].
PG  - A1246
AB  - A male newborn with generalized hypotonia and imminent respiratory insufficiency 
      was diagnosed with a metabolic disorder with a bad prognosis. To assure patient
      anonymity the exact diagnosis is not mentioned. The clinicians and the parents
      had different opinions about whether the treatment started should be continued.
      When paediatricians and parents differ in opinion, medical and moral facts will
      play an important role in deciding what is in the best interest of the child.
      These ethical dilemmas cause moral stress. Paediatricians and parents both have
      an obligation to weigh and balance all facts, values and uncertainties. Ethical
      case deliberations can be a valuable addition towards medical decision-making.
      Working on the ward, an ethicist can guide ethical deliberations and help
      treatment teams in making moral judgments. A structured case deliberation with
      ethical sound arguments based on widely held norms and values can enable
      consensus to be reached about the best approach. The ethicist must safeguard this
      process and help the treatment team to deal with moral stress. Especially in
      paediatrics, ethical dilemmas and moral questions will occur frequently.
FAU - Romer, Philip J M
AU  - Romer PJ
AD  - VU Medisch Centrum, Afd. Neonatologie, Amsterdam, The Netherlands.
      p.romer@vumc.nl
FAU - Smink, H Joke C
AU  - Smink HJ
FAU - van Elburg, Ruurd M
AU  - van Elburg RM
LA  - dut
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - Ethische besprekingen op de afdeling Neonatologie.
PL  - Netherlands
TA  - Ned Tijdschr Geneeskd
JT  - Nederlands tijdschrift voor geneeskunde
JID - 0400770
SB  - IM
MH  - Decision Making
MH  - *Ethics, Medical
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - Neonatology/*standards
MH  - Netherlands
MH  - Parents/*psychology
EDAT- 2010/05/12 06:00
MHDA- 2010/06/09 06:00
CRDT- 2010/05/12 06:00
PHST- 2010/05/12 06:00 [entrez]
PHST- 2010/05/12 06:00 [pubmed]
PHST- 2010/06/09 06:00 [medline]
PST - ppublish
SO  - Ned Tijdschr Geneeskd. 2010;154:A1246.


PMID- 20456706
OWN - NLM
STAT- MEDLINE
DCOM- 20101130
LR  - 20101102
IS  - 1537-2995 (Electronic)
IS  - 0041-1132 (Linking)
VI  - 50
IP  - 10
DP  - 2010 Oct
TI  - Obtaining of CD34+ cells from healthy blood donors: development of a rapid and
      efficient procedure using leukoreduction filters.
PG  - 2152-7
LID - 10.1111/j.1537-2995.2010.02683.x [doi]
AB  - BACKGROUND: Human CD34+ cells are mandatory to study many aspects of human
      hematopoiesis. Their low frequency in blood or marrow and ethical reasons limit
      their obtainment in large quantities. Leukoreduction filters (LRFs) are discarded
      after preparation of red blood cells. The CD34+ cell concentration in healthy
      donor blood is low (1x10(3) -4x10(3) /mL), but their number trapped in one LRF
      after filtration of 400 to 450mL of blood is high (0.4x10(6) -1.6x10(6) ). STUDY 
      DESIGN AND METHODS: To develop a procedure allowing obtainment of purified CD34+ 
      cells from LRFs with a good yield, white blood cell (WBC) recoveries after a
      500-mL continuous or after sequential elution (50- or 20-mL fractions) were
      compared. Different WBC and mononuclear cell (MNC) centrifugation methods were
      tested to minimize their PLT contamination before the CD34+ cell immunomagnetic
      selection. Cell functionality was finally analyzed under various culture
      conditions. RESULTS: The 20-mL back-flushing of LRFs allowed the most efficient
      WBC recovery. The next steps (110xg centrifugation, MNC separation on Ficoll, and
      washes) resulted in a cell suspension in which the lymphocyte recovery was
      approximately 76+/-10% and the PLT contamination below 1.6%. After immunomagnetic
      selection, 4x10(5) to 6x10(5) cells containing approximately 85% of functional
      CD34+ cells were obtained. CONCLUSION: This procedure allows the easy, rapid
      (<5hr), and efficient preparation of large quantities of CD34+ cells having
      functional activities similar to those of CD34+ cells from other sources.
      Therefore, easily available and virally safe, LRFs represent an important and
      regular WBC source to work with human CD34+ cells, but also with other WBC types.
CI  - (c) 2010 American Association of Blood Banks.
FAU - Peytour, Yann
AU  - Peytour Y
AD  - CNRS UMR 5164, University of Bordeaux 2, Etablissement Francais du Sang
      Aquitaine-Limousin, Laboratoire d'Hematologie, CHU of Bordeaux, Bordeaux, France.
FAU - Guitart, Amelie
AU  - Guitart A
FAU - Villacreces, Arnaud
AU  - Villacreces A
FAU - Chevaleyre, Jean
AU  - Chevaleyre J
FAU - Lacombe, Francis
AU  - Lacombe F
FAU - Ivanovic, Zoran
AU  - Ivanovic Z
FAU - Praloran, Vincent
AU  - Praloran V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101004
PL  - United States
TA  - Transfusion
JT  - Transfusion
JID - 0417360
RN  - 0 (Antigens, CD34)
SB  - IM
MH  - Antigens, CD34/*metabolism
MH  - Blood Donors
MH  - Cell Differentiation
MH  - Cell Separation/methods
MH  - Flow Cytometry
MH  - Humans
MH  - Leukocyte Reduction Procedures/*methods
MH  - Leukocytes, Mononuclear/*cytology/*metabolism
EDAT- 2010/05/12 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/05/12 06:00
PHST- 2010/05/12 06:00 [entrez]
PHST- 2010/05/12 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - TRF2683 [pii]
AID - 10.1111/j.1537-2995.2010.02683.x [doi]
PST - ppublish
SO  - Transfusion. 2010 Oct;50(10):2152-7. doi: 10.1111/j.1537-2995.2010.02683.x. Epub 
      2010 Oct 4.


PMID- 20456474
OWN - NLM
STAT- MEDLINE
DCOM- 20100819
LR  - 20181201
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 10
IP  - 2
DP  - 2010 Aug
TI  - From medical rationing to rationalizing the use of human resources for AIDS care 
      and treatment in Africa: a case for task shifting.
PG  - 99-103
LID - 10.1111/j.1471-8847.2010.00281.x [doi]
AB  - With a global commitment to scaling up AIDS care and treatment in resource-poor
      settings for some of the most HIV-affected countries in Africa, availability of
      antiretroviral treatment is no longer the principal obstacle to expanding access 
      to treatment. A shortage of trained healthcare personnel to initiate treatment
      and manage patients represents a more challenging barrier to offering life-saving
      treatment to all patients in need. Physician-centered treatment policies
      accentuate this challenge. Despite evidence that task shifting for nurse-centered
      AIDS patient care is effective and can alleviate severe physician shortages that 
      currently obstruct treatment scale-up, political commitment and policy action to 
      support task shifting models of care has been slow to absent. In this paper we
      review the evidence in support of task shifting for AIDS treatment in Africa and 
      argue that continued policy inaction amounts to unwarranted healthcare rationing 
      and as such is ethically untenable.
FAU - Price, Jessica
AU  - Price J
AD  - Family Health International, Kigali, Rwanda. jprice@fhi.org
FAU - Binagwaho, Agnes
AU  - Binagwaho A
LA  - eng
PT  - Journal Article
DEP - 20100426
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/drug therapy/*therapy
MH  - Africa
MH  - Anti-HIV Agents/administration & dosage
MH  - *Drug Prescriptions
MH  - Health Care Rationing/ethics/*trends
MH  - Health Personnel/education/trends
MH  - Health Policy/trends
MH  - Health Services Accessibility/*trends
MH  - Health Workforce/standards/*trends
MH  - Humans
MH  - Needs Assessment
MH  - *Physician's Role
EDAT- 2010/05/12 06:00
MHDA- 2010/08/20 06:00
CRDT- 2010/05/12 06:00
PHST- 2010/05/12 06:00 [entrez]
PHST- 2010/05/12 06:00 [pubmed]
PHST- 2010/08/20 06:00 [medline]
AID - DEWB281 [pii]
AID - 10.1111/j.1471-8847.2010.00281.x [doi]
PST - ppublish
SO  - Dev World Bioeth. 2010 Aug;10(2):99-103. doi: 10.1111/j.1471-8847.2010.00281.x.
      Epub 2010 Apr 26.


PMID- 20455752
OWN - NLM
STAT- MEDLINE
DCOM- 20100916
LR  - 20211020
IS  - 1557-8100 (Electronic)
IS  - 1536-2310 (Linking)
VI  - 14
IP  - 3
DP  - 2010 Jun
TI  - Standardization and omics science: technical and social dimensions are
      inseparable and demand symmetrical study.
PG  - 327-32
LID - 10.1089/omi.2010.0022 [doi]
AB  - Standardization is critical to scientists and regulators to ensure the quality
      and interoperability of research processes, as well as the safety and efficacy of
      the attendant research products. This is perhaps most evident in the case of
      "omics science," which is enabled by a host of diverse high-throughput
      technologies such as genomics, proteomics, and metabolomics. But standards are of
      interest to (and shaped by) others far beyond the immediate realm of individual
      scientists, laboratories, scientific consortia, or governments that develop,
      apply, and regulate them. Indeed, scientific standards have consequences for the 
      social, ethical, and legal environment in which innovative technologies are
      regulated, and thereby command the attention of policy makers and citizens. This 
      article argues that standardization of omics science is both technical and
      social. A critical synthesis of the social science literature indicates that: (1)
      standardization requires a degree of flexibility to be practical at the level of 
      scientific practice in disparate sites; (2) the manner in which standards are
      created, and by whom, will impact their perceived legitimacy and therefore their 
      potential to be used; and (3) the process of standardization itself is important 
      to establishing the legitimacy of an area of scientific research.
FAU - Holmes, Christina
AU  - Holmes C
AD  - Technoscience and Regulation Research Unit, Faculty of Medicine, Dalhousie
      University, Halifax, Canada.
FAU - McDonald, Fiona
AU  - McDonald F
FAU - Jones, Mavis
AU  - Jones M
FAU - Ozdemir, Vural
AU  - Ozdemir V
FAU - Graham, Janice E
AU  - Graham JE
LA  - eng
GR  - CIHR MOP 74473/Canadian Institutes of Health Research/Canada
GR  - R0016158/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - OMICS
JT  - Omics : a journal of integrative biology
JID - 101131135
SB  - IM
MH  - Communication
MH  - *Genomics
MH  - Humans
MH  - *Proteomics
MH  - *Reference Standards
MH  - Research
MH  - *Social Sciences
RF  - 42
PMC - PMC3128304
EDAT- 2010/05/12 06:00
MHDA- 2010/09/18 06:00
CRDT- 2010/05/12 06:00
PHST- 2010/05/12 06:00 [entrez]
PHST- 2010/05/12 06:00 [pubmed]
PHST- 2010/09/18 06:00 [medline]
AID - 10.1089/omi.2010.0022 [doi]
PST - ppublish
SO  - OMICS. 2010 Jun;14(3):327-32. doi: 10.1089/omi.2010.0022.


PMID- 20455376
OWN - NLM
STAT- MEDLINE
DCOM- 20100607
LR  - 20100511
IS  - 0031-7179 (Print)
IS  - 0031-7179 (Linking)
VI  - 73
IP  - 2
DP  - 2010 Spring
TI  - Ethical issues in the use of cognitive enhancement.
PG  - 16-22
FAU - Darby, Ryan
AU  - Darby R
AD  - darby.ryan@gmail.com
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pharos Alpha Omega Alpha Honor Med Soc
JT  - The Pharos of Alpha Omega Alpha-Honor Medical Society. Alpha Omega Alpha
JID - 19610620R
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Nootropic Agents)
SB  - IM
MH  - Attention
MH  - *Bioethical Issues
MH  - Biomedical Enhancement/*ethics/methods
MH  - Biomedical Research/ethics
MH  - Central Nervous System Stimulants/therapeutic use
MH  - *Cognition
MH  - Cognitive Science/*ethics/methods
MH  - Humans
MH  - Nootropic Agents/therapeutic use
EDAT- 2010/05/12 06:00
MHDA- 2010/06/09 06:00
CRDT- 2010/05/12 06:00
PHST- 2010/05/12 06:00 [entrez]
PHST- 2010/05/12 06:00 [pubmed]
PHST- 2010/06/09 06:00 [medline]
PST - ppublish
SO  - Pharos Alpha Omega Alpha Honor Med Soc. 2010 Spring;73(2):16-22.


PMID- 20455191
OWN - NLM
STAT- MEDLINE
DCOM- 20100810
LR  - 20100510
IS  - 1439-1074 (Electronic)
IS  - 0939-2661 (Linking)
VI  - 45
IP  - 5
DP  - 2010 May
TI  - [Organ transplantation in Germany - Legal framework and organizational
      management].
PG  - 348-54
LID - 10.1055/s-0030-1253569 [doi]
AB  - Organ transplantation is the therapeutic option of choice in organ failure and
      distinct types of cancer. For more than two decades organ transplantation had no 
      legal framework in Germany. Multiple ethical and judicial considerations as well 
      as the complexity of medical and organizational management but also the fears of 
      possible organ donors lead to the enacting of German Transplantation Act
      (Transplantationsgesetz, TPG) in 1997. The TPG defines controlled brain death and
      the extended consent as requirements for explantation. This means, the organ
      donor must have approved the donation of his organs before. This approval can be 
      writtenly documented or approved by the nearest relatives or the closest
      confidents. It is also possible to denominate an assignee (alt.: to authorize
      another person) during life time. Living organ donations are also legalized in
      the TPG. Precondition for any organ donation is the brain death of the organ
      donor. The diagnostic requirements for brain death are specifically mentioned by 
      guidelines of the German Federal Medical Association (Bundesarztekammer). The
      major problem today is willingness to organ donation in the German population.
      There is an eminent deficiency of organ donations in Germany. Therefore local
      hospitals, regional Transplantation Centres, the supraregional German Foundation 
      for Organ transplantation have to act closely in concert based on the directives 
      of TPG. After successful Transplantation, a life- long immunosuppression is
      necessary. Nevertheless organ rejections remain still possible. By reason of this
      and other complications a life-long connection to a responsible Transplantation
      Centre is necessary for the transplanted patient. Physicians who work at a
      regional hospital's ICU have to be able to identify possible organ donators. They
      also should know how to initiate the organizational procedures to provide
      explantation, rapid procuration, and transportation of the explanted organs based
      upon to the regulations of TPG.
CI  - Georg Thieme Verlag Stuttgart * New York.
FAU - Rommel, Wolf
AU  - Rommel W
AD  - Klinik fur Klinische und Experimentelle Transplantationshepatologie,
      Universitatsklinikum Munster. wolf.rommel@ukmuenster.de
FAU - Schmidt, Hartmut H J
AU  - Schmidt HH
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Organtransplantationen - Aktuelle rechtliche und organisatorische
      Rahmenbedingungen.
DEP - 20100507
PL  - Germany
TA  - Anasthesiol Intensivmed Notfallmed Schmerzther
JT  - Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS
JID - 9109478
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Germany
MH  - Heart Transplantation/legislation & jurisprudence/statistics & numerical data
MH  - Humans
MH  - Immunosuppressive Agents/therapeutic use
MH  - International Cooperation
MH  - Intestine, Small/transplantation
MH  - Legislation, Medical/trends
MH  - Liver Transplantation/legislation & jurisprudence/statistics & numerical data
MH  - Living Donors/statistics & numerical data
MH  - Nerve Tissue/transplantation
MH  - Organ Transplantation/*legislation & jurisprudence/*statistics & numerical data
MH  - Pancreas Transplantation/legislation & jurisprudence/statistics & numerical data
MH  - Tissue and Organ Procurement/statistics & numerical data
MH  - *Transplantation Immunology/immunology
EDAT- 2010/05/11 06:00
MHDA- 2010/08/11 06:00
CRDT- 2010/05/11 06:00
PHST- 2010/05/11 06:00 [entrez]
PHST- 2010/05/11 06:00 [pubmed]
PHST- 2010/08/11 06:00 [medline]
AID - 10.1055/s-0030-1253569 [doi]
PST - ppublish
SO  - Anasthesiol Intensivmed Notfallmed Schmerzther. 2010 May;45(5):348-54. doi:
      10.1055/s-0030-1253569. Epub 2010 May 7.


PMID- 20454794
OWN - NLM
STAT- MEDLINE
DCOM- 20101208
LR  - 20211020
IS  - 1279-8517 (Electronic)
IS  - 0930-1038 (Linking)
VI  - 32
IP  - 7
DP  - 2010 Aug
TI  - Anatomical dimensions of larynx, epiglottis and cricoid cartilage in foetuses and
      their relationship with crown rump length.
PG  - 675-81
LID - 10.1007/s00276-010-0670-0 [doi]
AB  - BACKGROUND: Advances in perinatal care and increased use of diagnostic and
      interventional procedures on foetal airway demand a clear understanding of their 
      normal anatomy and development. This study is aimed at determining the normal
      dimensions of larynx, cricoid cartilage and epiglottis and their correlation to
      age and crown rump length (CRL). METHOD: After approval from institutional ethics
      committee and written parental informed consent, laryngeal measurements were
      taken from 79 foetuses of varying CRL from 30 to 299 mm. The entire larynx from
      the tip of epiglottis to lowest extension of thyroid gland was isolated and
      preserved. In small foetuses (30-165 mm) the measurements were taken under a
      dissecting microscope. In foetuses above the CRL of 165 mm, the measurements were
      taken with help of Vernier Calliper. RESULTS: Foetuses were analysed for
      dimensions based on CRL. The length of the larynx significantly increased in
      comparison to CRL (P < 0.001). Similar measurements were observed for transverse 
      diameter, anteroposterior diameter and inter-cartilaginous distance of larynx,
      the anterior height of arch and posterior height of lamina of cricoid cartilage
      and the length and breadth of epiglottis. The internal anteroposterior and
      transverse diameter of cricoid cartilage showed no correlation with CRL.
      CONCLUSION: All the measured parameters of larynx, epiglottis and cricoid
      cartilage showed positive correlation with the CRL except the internal diameters 
      of cricoid.
FAU - Harjeet, K
AU  - Harjeet K
AD  - Department of Anatomy, Postgraduate Institute of Medical Education and Research, 
      Chandigarh, India.
FAU - Aggarwal, Anjali
AU  - Aggarwal A
FAU - Sahni, Daisy
AU  - Sahni D
FAU - Batra, Yatindra Kumar
AU  - Batra YK
FAU - Rakesh, S V
AU  - Rakesh SV
FAU - Subramanyam, Rajeev
AU  - Subramanyam R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100508
PL  - Germany
TA  - Surg Radiol Anat
JT  - Surgical and radiologic anatomy : SRA
JID - 8608029
SB  - IM
MH  - Analysis of Variance
MH  - Cricoid Cartilage/*embryology
MH  - Crown-Rump Length
MH  - Epiglottis/*embryology
MH  - Female
MH  - Fetus/*anatomy & histology
MH  - Humans
MH  - Larynx/*embryology
MH  - Male
MH  - Statistics, Nonparametric
EDAT- 2010/05/11 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/05/11 06:00
PHST- 2009/11/19 00:00 [received]
PHST- 2010/04/13 00:00 [accepted]
PHST- 2010/05/11 06:00 [entrez]
PHST- 2010/05/11 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1007/s00276-010-0670-0 [doi]
PST - ppublish
SO  - Surg Radiol Anat. 2010 Aug;32(7):675-81. doi: 10.1007/s00276-010-0670-0. Epub
      2010 May 8.


PMID- 20453611
OWN - NLM
STAT- MEDLINE
DCOM- 20100908
LR  - 20100510
IS  - 1529-7535 (Print)
IS  - 1529-7535 (Linking)
VI  - 11
IP  - 3
DP  - 2010 May
TI  - Critical appraisal of: triaging pediatric critical care resources during a
      pandemic: ethical and medical considerations.
PG  - 396-400
LID - 10.1097/PCC.0b013e3181dac698 [doi]
AB  - OBJECTIVE: To identify the ethical norms that should govern the allocation of
      pediatric critical care resources during a pandemic. DESIGN: Narrative review.
      METHODS: Review the literature on triage and pandemics. FINDINGS: When care that 
      is functionally equivalent to usual patient care practices can no longer be
      maintained, resources should be allocated primarily on the basis of medical need 
      and/or benefit. Unequal treatment may be justified to increase the supply of
      available resources and thereby save more lives. When ethically relevant
      distinctions can no longer be made between patients, resources should be
      distributed by chance. Allocation on the basis of quality of life, general
      contributions to society, or age are potentially problematic. Existing triage
      protocols inconsistently articulate the relationship between these ethical norms 
      and their specific recommendations. In addition, they have limited applicability 
      in pediatrics principally because of the lack of a simple validated global
      scoring system, which predicts mortality and/or resource utilization.
      CONCLUSIONS: Although research to develop such scoring systems is ongoing,
      clinicians will need to rely more heavily on individual diagnoses of acute
      illnesses with high mortality rates and underlying conditions with short life
      expectancies and on random allocation methods.
FAU - Antommaria, Armand H Matheny
AU  - Antommaria AH
AD  - Division of Medical Ethics and Humanities, University of Utah School of Medicine,
      Salt Lake City, UT, USA. armand.antommaria@hsc.utah.edu
FAU - Sweney, Jill
AU  - Sweney J
FAU - Poss, W Bradley
AU  - Poss WB
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pediatr Crit Care Med
JT  - Pediatric critical care medicine : a journal of the Society of Critical Care
      Medicine and the World Federation of Pediatric Intensive and Critical Care
      Societies
JID - 100954653
SB  - IM
CIN - Pediatr Crit Care Med. 2010 May;11(3):436-8. PMID: 20453622
MH  - Age Factors
MH  - Child, Preschool
MH  - *Critical Care
MH  - Disease Outbreaks
MH  - Health Care Rationing/*ethics
MH  - Health Services Needs and Demand
MH  - Humans
MH  - Infant
MH  - *Influenza A Virus, H1N1 Subtype
MH  - Influenza, Human/*epidemiology
MH  - Triage/*ethics
MH  - United States/epidemiology
EDAT- 2010/05/11 06:00
MHDA- 2010/09/09 06:00
CRDT- 2010/05/11 06:00
PHST- 2010/05/11 06:00 [entrez]
PHST- 2010/05/11 06:00 [pubmed]
PHST- 2010/09/09 06:00 [medline]
AID - 10.1097/PCC.0b013e3181dac698 [doi]
AID - 00130478-201005000-00013 [pii]
PST - ppublish
SO  - Pediatr Crit Care Med. 2010 May;11(3):396-400. doi: 10.1097/PCC.0b013e3181dac698.


PMID- 20453588
OWN - NLM
STAT- MEDLINE
DCOM- 20100826
LR  - 20100510
IS  - 1539-0683 (Electronic)
IS  - 0361-929X (Linking)
VI  - 35
IP  - 3
DP  - 2010 May-Jun
TI  - Egg donation: issues & concerns.
PG  - 132-7; quiz 137-9
LID - 10.1097/NMC.0b013e3181d763b9 [doi]
AB  - There is an increasing trend in the use of donor eggs by women unable to
      otherwise conceive. Third-party reproduction, specifically in vitro fertilization
      (IVF) with donor eggs, has particular ethical issues including possible conflict 
      of interest between provider, donor, and recipient; completeness of informed
      consent; whether the donor has legal representation; and follow-up support.
      Nurses working with women who might have IVF are in a position to positively
      affect the egg donor's experience by making sure that donors understand the risks
      as well as the benefits of egg donation.
FAU - Black, Jennifer J
AU  - Black JJ
AD  - Virginia Commonwealth University, School of Nursing, Richmond, VA, USA.
      jjblack@vcu.edu
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - MCN Am J Matern Child Nurs
JT  - MCN. The American journal of maternal child nursing
JID - 7605941
SB  - IM
MH  - Aftercare
MH  - Confidentiality
MH  - Conflict of Interest
MH  - Female
MH  - Fertilization in Vitro/methods/trends
MH  - Humans
MH  - Informed Consent
MH  - Nurse's Role
MH  - Oocyte Donation/adverse effects/*ethics/legislation &
      jurisprudence/*nursing/*psychology
MH  - Patient Advocacy
MH  - Patient Care Team
MH  - Patient Education as Topic
MH  - Practice Guidelines as Topic
MH  - Risk Factors
MH  - Social Support
MH  - Tissue Donors/education/*ethics/legislation & jurisprudence/*psychology
MH  - United States
EDAT- 2010/05/11 06:00
MHDA- 2010/08/27 06:00
CRDT- 2010/05/11 06:00
PHST- 2010/05/11 06:00 [entrez]
PHST- 2010/05/11 06:00 [pubmed]
PHST- 2010/08/27 06:00 [medline]
AID - 10.1097/NMC.0b013e3181d763b9 [doi]
AID - 00005721-201005000-00003 [pii]
PST - ppublish
SO  - MCN Am J Matern Child Nurs. 2010 May-Jun;35(3):132-7; quiz 137-9. doi:
      10.1097/NMC.0b013e3181d763b9.


PMID- 20453468
OWN - NLM
STAT- MEDLINE
DCOM- 20110407
LR  - 20101207
IS  - 1662-8063 (Electronic)
IS  - 1662-4246 (Linking)
VI  - 13
IP  - 7-8
DP  - 2010
TI  - Relative responsibilities: is there an obligation to discuss genomics research
      participation with family members?
PG  - 504-13
LID - 10.1159/000294207 [doi]
AB  - One of the many ethical challenges presented by research in genomics is that,
      although informed consent to research has traditionally been a matter for the
      individual participant, genomics research carries potential implications for
      genetic relatives. There are specific issues that arise when research is focused 
      around populations or around family groups; this paper deals with the place of
      relatives of participants in genomics research more generally. Recently, in
      response to this challenge, recommendations have attempted to tread a middle
      ground by retaining traditional models of informed consent whilst suggesting that
      potential research recruits should be encouraged to discuss participation with
      their families. It is argued here that this may produce an unfair account of the 
      responsibilities of research participants, that it may ignore the very many
      difficulties of communication within families about genetics and health, and that
      it may create unrealistic hurdles to the ethical conduct of research. Research
      conducted in the context of clinical genetics and on health communication more
      widely is drawn upon to illustrate these points. A clear recommendation is made
      that providing materials that may assist research participants to communicate
      with family members may be beneficial and may raise ethical standards, but that
      it may be unwise to burden participants with the suggestion that they owe
      specific obligations to genetic relatives to discuss research participation with 
      them.
CI  - Copyright (c) 2010 S. Karger AG, Basel.
FAU - Boddington, P
AU  - Boddington P
AD  - Division of Public Health and Primary Health Care, Ethox Centre, Oxford
      University, Oxford, UK. paula.boddington@ethox.ox.ac.uk
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100504
PL  - Switzerland
TA  - Public Health Genomics
JT  - Public health genomics
JID - 101474167
SB  - IM
MH  - Family/*psychology
MH  - Genetic Predisposition to Disease/*psychology
MH  - Genetic Research/*ethics
MH  - *Genomics
MH  - Humans
MH  - Patient Participation/*psychology
EDAT- 2010/05/11 06:00
MHDA- 2011/04/08 06:00
CRDT- 2010/05/11 06:00
PHST- 2009/08/03 00:00 [received]
PHST- 2009/11/27 00:00 [accepted]
PHST- 2010/05/11 06:00 [entrez]
PHST- 2010/05/11 06:00 [pubmed]
PHST- 2011/04/08 06:00 [medline]
AID - 000294207 [pii]
AID - 10.1159/000294207 [doi]
PST - ppublish
SO  - Public Health Genomics. 2010;13(7-8):504-13. doi: 10.1159/000294207. Epub 2010
      May 4.


PMID- 20451995
OWN - NLM
STAT- MEDLINE
DCOM- 20110128
LR  - 20100824
IS  - 1879-3231 (Electronic)
IS  - 0093-691X (Linking)
VI  - 74
IP  - 5
DP  - 2010 Sep 15
TI  - Different temporal gene expression patterns for ovine pre-implantation embryos
      produced by parthenogenesis or in vitro fertilization.
PG  - 712-23
LID - 10.1016/j.theriogenology.2010.03.024 [doi]
AB  - Parthenogenetic activation of the mammalian oocyte constitutes an essential step 
      to a number of oocyte- or embryo-related technologies. Mammalian parthenotes are 
      useful tools for studying the roles of paternal and maternal genomes in early
      mammalian development and are considered potential candidates for an ethical
      source of embryonic stem cells. We investigated the in vitro developmental
      competence of pre-implantation ovine embryos derived from in vitro fertilization 
      (IVF) and parthenogenetic activation (PA) together with the expression of a panel
      of fourteen genes at different times of development. IVF and PA embryos showed
      similar developmental competence. No differences in gene expression were observed
      between PA and IVF two cell-stage embryos, while PA morulae showed a
      significantly higher expression of IGF2. At the blastocyst stage, parthenotes
      exhibited up-regulation of TP-1, CDC2, and IGF2 transcripts and significantly
      lower levels of AQP3, ATP1A1, H2A.Z, hsp90beta, and OCT4, while NANOG, BAX,
      CCNB1, CDH1, GAPDH, and IGF2R displayed similar expression patterns in the two
      groups. Our study indicates that oocyte parthenogenetic activation does not
      impair in vitro pre-implantation development to the blastocyst stage, but affects
      the gene expression status of the embryo after the activation of its own genome.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Bebbere, Daniela
AU  - Bebbere D
AD  - Department of Veterinary Clinics and Pathology, University of Sassari, Sassari,
      Italy. dbebbere@uniss.it
FAU - Bogliolo, Luisa
AU  - Bogliolo L
FAU - Ariu, Federica
AU  - Ariu F
FAU - Fois, Stefano
AU  - Fois S
FAU - Leoni, Giovanni Giuseppe
AU  - Leoni GG
FAU - Succu, Sara
AU  - Succu S
FAU - Berlinguer, Fiammetta
AU  - Berlinguer F
FAU - Ledda, Sergio
AU  - Ledda S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100507
PL  - United States
TA  - Theriogenology
JT  - Theriogenology
JID - 0421510
RN  - 0 (Proteins)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Blastocyst/*metabolism
MH  - Embryonic Development/genetics
MH  - Female
MH  - Fertilization in Vitro/*veterinary
MH  - *Gene Expression
MH  - Gene Expression Profiling/veterinary
MH  - Gene Expression Regulation, Developmental
MH  - Genome
MH  - Male
MH  - Molecular Sequence Data
MH  - Parthenogenesis/*genetics
MH  - Proteins/genetics/metabolism
MH  - Sequence Alignment
MH  - Sheep/*genetics
EDAT- 2010/05/11 06:00
MHDA- 2011/02/01 06:00
CRDT- 2010/05/11 06:00
PHST- 2009/10/12 00:00 [received]
PHST- 2010/03/23 00:00 [revised]
PHST- 2010/03/25 00:00 [accepted]
PHST- 2010/05/11 06:00 [entrez]
PHST- 2010/05/11 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
AID - S0093-691X(10)00184-6 [pii]
AID - 10.1016/j.theriogenology.2010.03.024 [doi]
PST - ppublish
SO  - Theriogenology. 2010 Sep 15;74(5):712-23. doi:
      10.1016/j.theriogenology.2010.03.024. Epub 2010 May 7.


PMID- 20451889
OWN - NLM
STAT- MEDLINE
DCOM- 20100930
LR  - 20100906
IS  - 1097-6868 (Electronic)
IS  - 0002-9378 (Linking)
VI  - 203
IP  - 3
DP  - 2010 Sep
TI  - A new approach to professional liability reform: placing obligations of
      stakeholders ahead of their interests.
PG  - 203.e1-7
LID - 10.1016/j.ajog.2010.03.012 [doi]
AB  - The authors utilize stakeholder theory to provide a new analysis of the
      professional liability crisis, by identifying the major stakeholders in our
      current system of professional liability, their respective obligations and
      self-interests, and how these interests are advanced and constrained by the
      current system. This stakeholder analysis reveals a core ethical obligation of
      all stakeholders: the preservation of the integrity of our current judicial
      system. The adverse impact of the pursuit of stakeholder self-interests, rather
      than fulfillment of their core, shared ethical obligation, on achievement of the 
      goals of the current system, the deterrence of unsafe practice and compensation
      of injured patients, is then identified. The authors argue that approaches to
      reform of professional liability in obstetrics be based upon the common
      obligation of the stakeholders to fulfill the goals of the system, because
      attempts to align the myriad self-interests of the stakeholders will be futile.
CI  - Copyright 2010 Mosby, Inc. All rights reserved.
FAU - Chervenak, Judith L
AU  - Chervenak JL
AD  - Department of Obstetrics and Gynecology, New York University School of Medicine, 
      New York, NY, USA.
FAU - Chervenak, Frank A
AU  - Chervenak FA
FAU - McCullough, Laurence B
AU  - McCullough LB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100508
PL  - United States
TA  - Am J Obstet Gynecol
JT  - American journal of obstetrics and gynecology
JID - 0370476
SB  - IM
MH  - Compensation and Redress
MH  - *Health Care Reform
MH  - Humans
MH  - *Liability, Legal
MH  - Malpractice/*legislation & jurisprudence
MH  - Medical Errors/prevention & control
MH  - Obstetrics
MH  - Safety
MH  - United States
EDAT- 2010/05/11 06:00
MHDA- 2010/10/01 06:00
CRDT- 2010/05/11 06:00
PHST- 2009/12/23 00:00 [received]
PHST- 2010/01/31 00:00 [revised]
PHST- 2010/03/05 00:00 [accepted]
PHST- 2010/05/11 06:00 [entrez]
PHST- 2010/05/11 06:00 [pubmed]
PHST- 2010/10/01 06:00 [medline]
AID - S0002-9378(10)00310-8 [pii]
AID - 10.1016/j.ajog.2010.03.012 [doi]
PST - ppublish
SO  - Am J Obstet Gynecol. 2010 Sep;203(3):203.e1-7. doi: 10.1016/j.ajog.2010.03.012.
      Epub 2010 May 8.


PMID- 20451839
OWN - NLM
STAT- MEDLINE
DCOM- 20100818
LR  - 20110106
IS  - 1528-395X (Electronic)
IS  - 1079-2104 (Linking)
VI  - 109
IP  - 6
DP  - 2010 Jun
TI  - Ethics in publication.
PG  - 797-8
LID - 10.1016/j.tripleo.2010.03.027 [doi]
FAU - Spangberg, Larz S W
AU  - Spangberg LS
LA  - eng
PT  - Editorial
PL  - United States
TA  - Oral Surg Oral Med Oral Pathol Oral Radiol Endod
JT  - Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
JID - 9508562
SB  - IM
CIN - Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Jan;111(1):10-2. PMID:
      21176817
MH  - *Endodontics
MH  - *Fraud
MH  - Humans
MH  - Journalism, Dental/*standards
MH  - Peer Review
MH  - Periodicals as Topic/ethics/standards
MH  - Publications/*ethics
MH  - Publishing/*ethics
MH  - Scientific Misconduct
EDAT- 2010/05/11 06:00
MHDA- 2010/08/19 06:00
CRDT- 2010/05/11 06:00
PHST- 2010/05/11 06:00 [entrez]
PHST- 2010/05/11 06:00 [pubmed]
PHST- 2010/08/19 06:00 [medline]
AID - S1079-2104(10)00197-6 [pii]
AID - 10.1016/j.tripleo.2010.03.027 [doi]
PST - ppublish
SO  - Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Jun;109(6):797-8. doi:
      10.1016/j.tripleo.2010.03.027.


PMID- 20451193
OWN - NLM
STAT- MEDLINE
DCOM- 20101208
LR  - 20181201
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 94
IP  - 6
DP  - 2010 Nov
TI  - A decade of the United Kingdom sperm-washing program: untangling the
      transatlantic divide.
PG  - 2458-61
LID - 10.1016/j.fertnstert.2010.03.074 [doi]
AB  - Fertility assistance to HIV-positive men is now accepted practice in many parts
      of the world. We analyze the legislative, ethical, and clinical factors that
      explain the differences across continents with the aim of opening up the debate
      within the United States on whether clinics can justify denying HIV-infected men 
      the opportunity of parenting through a now well-established risk reduction method
      with a proved safety record.
CI  - Copyright (c) 2010 American Society for Reproductive Medicine. Published by
      Elsevier Inc. All rights reserved.
FAU - Nicopoullos, James D M
AU  - Nicopoullos JD
AD  - Assisted Conception Unit, Chelsea and Westminster Hospital, London, United
      Kingdom. jnicopoullos@aol.com
FAU - Almeida, Paula
AU  - Almeida P
FAU - Vourliotis, Maria
AU  - Vourliotis M
FAU - Gilling-Smith, Carole
AU  - Gilling-Smith C
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100507
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
SB  - IM
MH  - Cell Separation
MH  - Decontamination/ethics/legislation & jurisprudence/*methods/standards
MH  - Disease Transmission, Infectious/ethics/legislation & jurisprudence/prevention & 
      control
MH  - Female
MH  - *HIV Infections/transmission/virology
MH  - Humans
MH  - *International Cooperation/legislation & jurisprudence
MH  - Male
MH  - Pregnancy
MH  - *Reproductive Techniques, Assisted/ethics/legislation &
      jurisprudence/standards/statistics & numerical data
MH  - *Sperm Retrieval/ethics/legislation & jurisprudence/standards
MH  - Spermatozoa/cytology/virology
MH  - United Kingdom
MH  - United States
EDAT- 2010/05/11 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/05/11 06:00
PHST- 2009/12/09 00:00 [received]
PHST- 2010/01/24 00:00 [revised]
PHST- 2010/03/26 00:00 [accepted]
PHST- 2010/05/11 06:00 [entrez]
PHST- 2010/05/11 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S0015-0282(10)00535-2 [pii]
AID - 10.1016/j.fertnstert.2010.03.074 [doi]
PST - ppublish
SO  - Fertil Steril. 2010 Nov;94(6):2458-61. doi: 10.1016/j.fertnstert.2010.03.074.
      Epub 2010 May 7.


PMID- 20451149
OWN - NLM
STAT- MEDLINE
DCOM- 20101007
LR  - 20100510
IS  - 1878-7541 (Electronic)
IS  - 1550-8307 (Linking)
VI  - 6
IP  - 3
DP  - 2010 May-Jun
TI  - Recruiting palliative patients for a large qualitative study: some ethical
      considerations and staff dilemmas.
PG  - 159-65
LID - 10.1016/j.explore.2010.03.008 [doi]
AB  - This article reports on the processes of staff members in referring patients to a
      study that explored the experience of palliative patients, family members, and
      health professionals with the implementation of a family meeting model as an
      instrument of spiritual care. The reported qualitative study was undertaken in
      two large metropolitan Australian hospitals. Criteria other than those set by the
      study protocol were employed by staff members referring patients. These included 
      subjective opinions of who was suitable to refer and perceptions of patients'
      attitudes to religion or spirituality. Such practices raise ethical issues and
      may compromise studies that have received ethics approval.
CI  - Crown Copyright (c) 2010. Published by Elsevier Inc. All rights reserved.
FAU - Tan, Heather
AU  - Tan H
AD  - School of Population Health and Clinical Practice, University of Adelaide,
      Adelaide, Australia.
FAU - Wilson, Anne
AU  - Wilson A
FAU - Olver, Ian
AU  - Olver I
FAU - Barton, Christopher
AU  - Barton C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Explore (NY)
JT  - Explore (New York, N.Y.)
JID - 101233160
SB  - IM
MH  - Australia
MH  - Clinical Trials as Topic/*ethics
MH  - Conflict of Interest
MH  - *Ethics, Research
MH  - Family
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - Health Personnel/*ethics
MH  - Holistic Health
MH  - Humans
MH  - Informed Consent
MH  - Male
MH  - Middle Aged
MH  - *Palliative Care/ethics
MH  - Patient Selection/*ethics
MH  - Qualitative Research
MH  - Religion
MH  - Spirituality
EDAT- 2010/05/11 06:00
MHDA- 2010/10/12 06:00
CRDT- 2010/05/11 06:00
PHST- 2010/05/11 06:00 [entrez]
PHST- 2010/05/11 06:00 [pubmed]
PHST- 2010/10/12 06:00 [medline]
AID - S1550-8307(10)00042-X [pii]
AID - 10.1016/j.explore.2010.03.008 [doi]
PST - ppublish
SO  - Explore (NY). 2010 May-Jun;6(3):159-65. doi: 10.1016/j.explore.2010.03.008.


PMID- 20450785
OWN - NLM
STAT- MEDLINE
DCOM- 20100817
LR  - 20151119
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 90
IP  - 9
DP  - 2010 Mar 9
TI  - [Investigation and analysis of status in simulation education of anesthesiology
      of China].
PG  - 614-7
AB  - OBJECTIVE: To investigate the status of simulation education of anesthesiology in
      China. METHODS: Five hundreds questionnaires were mailed to chairmen of
      department of anesthesiology in teaching hospitals in 29 provinces and autonomous
      regions in China. The retrieved questionnaires and data were processed and
      analyzed with statistics. RESULTS: Sixty one questionnaires were retrieved, and
      retrieved rate is 12.2%. The result indicated that the theory and knowledge of
      anesthesiology was adopted for the training of medical students and residents in 
      2% teaching hospitals, theory and knowledge of anesthesiology combined with
      problem-based learning discussion in 52% teaching hospitals, theory and knowledge
      of anesthesiology combined with problem-based learning discussion and simulation 
      training in 46% teaching hospitals. The order of simulation devices possessed was
      as follows: Basic Life Support (BLS) (79.6%), training model for clinical
      anesthesia techniques (53.1%) and Advances Life Support (ALS) (51.0%). There were
      only six teaching hospitals utilized Human Patient Simulator for anesthesia
      training. The result of evaluation of simulation education showed that 91.2%
      anesthesiologists recognized it as applicable, 90.1% anesthesiologists recognized
      it as medical ethic requirement and 86.0% anesthesiologists recognized it as
      partly close to clinical situation. The degree of cognition of anesthesiologists 
      to simulation education was ordered as follows: manipulation correcting ability
      (92.6%), procedure controllability (87.0%), training adjustability (76.0%) and
      patients safety (68.5%). CONCLUSION: The simulation education of anesthesiology
      in China is still in the preliminary period. The executive departments of
      education should enhance supports to the simulation education in both hard ware
      and in soft ware.
FAU - Wang, Tian-long
AU  - Wang TL
AD  - Department of Anesthesiology, Xuanwu Hospital, Capital Medical University,
      Beijing 100053, China.
FAU - Xue, Ji-xiu
AU  - Xue JX
FAU - Xiao, Wei
AU  - Xiao W
FAU - Wu, Xin-min
AU  - Wu XM
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
SB  - IM
MH  - Anesthesiology/*education
MH  - China
MH  - *Educational Technology
MH  - Surveys and Questionnaires
EDAT- 2010/05/11 06:00
MHDA- 2010/08/18 06:00
CRDT- 2010/05/11 06:00
PHST- 2010/05/11 06:00 [entrez]
PHST- 2010/05/11 06:00 [pubmed]
PHST- 2010/08/18 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2010 Mar 9;90(9):614-7.


PMID- 20450098
OWN - NLM
STAT- MEDLINE
DCOM- 20100615
LR  - 20100510
IS  - 1881-6096 (Print)
IS  - 1881-6096 (Linking)
VI  - 62
IP  - 5
DP  - 2010 May
TI  - [Review of the 2008 revision of the ethical guidelines for clinical studies].
PG  - 511-8
AB  - The ethical guidelines for clinical studies were revised in 2008 and enforced in 
      April 2009. This was the second revision but first regular revision and largely
      reviewed. In particular, articles under the purview of the Institutional Review
      Board (IRB) for clinical studies are reviewed and enhanced. This additional role 
      further increases the authority of the IRB, and those who fix the IRB must
      exhibit the activity of the IRB to the public and report to the MHLW annually.
      The provision of compensation for clinical studies on the evaluation of drugs and
      medical devices has been added to this version of the ethical guidelines. The
      compensation for interventional clinical studies using drugs and medical devices 
      has not yet been decided, similar to "chiken," which is defined in pharmaceutical
      affairs laws (PAL). Since April 2009, some insurance offices have started
      offering special insurance covers for clinical studies. New registration rules
      have been established for clinical studies. Moreover, there is now a database for
      clinical study registration called "Japan Primary Registries Network (JPRN),"
      which is certified by WHO. This database comprises 3 open databases, which were
      originally independent, related to clinical trials in Japan. They are however
      under the purview of the National Institute of Public Health. This institution
      works in collaboration with the "International Clinical Trials Registry Platform 
      (ICTRP)" of WHO.
FAU - Imoto, Masakatsu
AU  - Imoto M
AD  - Research and Development Division, Health Policy Bureau, Ministry of Health,
      Labour and Welfare, 1-2-2 Kasumigaseki, Chiyoda-ku, Tokyo 100-8916, Japan.
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Brain Nerve
JT  - Brain and nerve = Shinkei kenkyu no shinpo
JID - 101299709
SB  - IM
MH  - Clinical Trials as Topic/*ethics
MH  - Ethics Committees
MH  - *Guidelines as Topic
MH  - Humans
MH  - Informed Consent
EDAT- 2010/05/11 06:00
MHDA- 2010/06/16 06:00
CRDT- 2010/05/11 06:00
PHST- 2010/05/11 06:00 [entrez]
PHST- 2010/05/11 06:00 [pubmed]
PHST- 2010/06/16 06:00 [medline]
PST - ppublish
SO  - Brain Nerve. 2010 May;62(5):511-8.


PMID- 20450091
OWN - NLM
STAT- MEDLINE
DCOM- 20100602
LR  - 20100510
IS  - 1351-5578 (Print)
IS  - 1351-5578 (Linking)
VI  - 17
IP  - 3
DP  - 2010
TI  - Narrative and narrative enquiry in health and social sciences.
PG  - 72-84
AB  - Increasingly, narrative and life story are being used in health and social
      sciences, and other disciplines. Narrative analysis assumes multiple forms in a
      variety of analytic practices, with no single or correct way to analyse stories. 
      This paper explores the concepts and meanings of narrative and narrative enquiry;
      their ontology and epistemology, and their use as a research method will be
      discussed as well. Ethics will be addressed briefly. This paper will help readers
      to grasp the essential elements in understanding narrative and narrative enquiry.
FAU - Lai, Claudia K Y
AU  - Lai CK
AD  - School of Nursing, the Hong Kong Polytechnic University, Hong Kong, China.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurse Res
JT  - Nurse researcher
JID - 9435953
MH  - Humans
MH  - *Narration
MH  - Nursing Research/ethics/*methods
MH  - *Social Sciences
EDAT- 2010/05/11 06:00
MHDA- 2010/06/03 06:00
CRDT- 2010/05/11 06:00
PHST- 2010/05/11 06:00 [entrez]
PHST- 2010/05/11 06:00 [pubmed]
PHST- 2010/06/03 06:00 [medline]
AID - 10.7748/nr2010.04.17.3.72.c7748 [doi]
PST - ppublish
SO  - Nurse Res. 2010;17(3):72-84. doi: 10.7748/nr2010.04.17.3.72.c7748.


PMID- 20449982
OWN - NLM
STAT- MEDLINE
DCOM- 20100524
LR  - 20191210
IS  - 0033-2674 (Print)
IS  - 0033-2674 (Linking)
VI  - 44
IP  - 1
DP  - 2010 Jan-Feb
TI  - [Vagus nerve stimulation in therapy of depression--description of the method and 
      some critical remarks].
PG  - 71-88
AB  - Recently some new physical techniques were investigated for their antidepressive 
      efficacy. Only vagus nerve stimulation (VNS) was approved for treatment of
      chronic and/or recurrent depression. The submitted paper describes the VNS
      technique and presents several critical attentions. The main restrictions join
      with difficulties with complying of blind test conditions in clinical
      investigations. On one hand an ethical problem is providing the same stimulation 
      in a chronic test, i.e. leaving the implanted stimulator in the switched off
      state. In turn sensory experiences connected with a current flowing let the
      patient know that he receives true stimulation. The given conditions allow for a 
      critical attitude towards results from clinical investigations about the real
      efficacy of VNS technique. The declared advantages connected with the profile of 
      the VNS technique seem to be however illusory--in relationship with fact, that it
      is not an independent treatment method, but it is added to conventional
      pharmacotherapy.
FAU - Zyss, Tomasz
AU  - Zyss T
AD  - Oddzial Kliniczny Kliniki Psychiatrii, Doroslych Szpitala Uniwersyteckiego w
      Krakowie.
LA  - pol
PT  - Journal Article
PT  - Review
TT  - Stymulacja nerwu blednego w terapii depresji--opis metody i kilka krytycznych
      uwag.
PL  - Poland
TA  - Psychiatr Pol
JT  - Psychiatria polska
JID - 0103314
RN  - 0 (Antidepressive Agents)
SB  - IM
MH  - Antidepressive Agents
MH  - Combined Modality Therapy/methods
MH  - Depression/drug therapy/*therapy
MH  - Depressive Disorder/drug therapy/*therapy
MH  - Humans
MH  - Outcome Assessment, Health Care
MH  - Quality of Life
MH  - Treatment Outcome
MH  - Vagus Nerve/*physiopathology
MH  - Vagus Nerve Stimulation/adverse effects/*methods
RF  - 76
EDAT- 2010/05/11 06:00
MHDA- 2010/05/25 06:00
CRDT- 2010/05/11 06:00
PHST- 2010/05/11 06:00 [entrez]
PHST- 2010/05/11 06:00 [pubmed]
PHST- 2010/05/25 06:00 [medline]
PST - ppublish
SO  - Psychiatr Pol. 2010 Jan-Feb;44(1):71-88.


PMID- 20448518
OWN - NLM
STAT- MEDLINE
DCOM- 20100713
LR  - 20220311
IS  - 1092-8529 (Print)
IS  - 1092-8529 (Linking)
VI  - 15
IP  - 5
DP  - 2010 May
TI  - Separating hope from hype: some ethical implications of the development of deep
      brain stimulation in psychiatric research and treatment.
PG  - 285-7
FAU - Schlaepfer, Thomas E
AU  - Schlaepfer TE
AD  - University of Bonn, Germany.
FAU - Lisanby, S H
AU  - Lisanby SH
FAU - Pallanti, Stefano
AU  - Pallanti S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - CNS Spectr
JT  - CNS spectrums
JID - 9702877
SB  - IM
MH  - *Biomedical Research/ethics/methods
MH  - Deep Brain Stimulation/*ethics/*methods
MH  - Humans
MH  - Mental Disorders/*therapy
EDAT- 2010/05/08 06:00
MHDA- 2010/07/14 06:00
CRDT- 2010/05/08 06:00
PHST- 2010/05/08 06:00 [entrez]
PHST- 2010/05/08 06:00 [pubmed]
PHST- 2010/07/14 06:00 [medline]
AID - 10.1017/s1092852900027504 [doi]
PST - ppublish
SO  - CNS Spectr. 2010 May;15(5):285-7. doi: 10.1017/s1092852900027504.


PMID- 20448105
OWN - NLM
STAT- MEDLINE
DCOM- 20100813
LR  - 20220410
IS  - 1538-6724 (Electronic)
IS  - 0031-9023 (Linking)
VI  - 90
IP  - 7
DP  - 2010 Jul
TI  - Closing the gap between ethics knowledge and practice through active engagement: 
      an applied model of physical therapy ethics.
PG  - 1068-78
LID - 10.2522/ptj.20090379 [doi]
AB  - Physical therapist practice has a distinct focus that is holistic (ie, patient
      centered) and at the same time connected to a range of other providers within
      health care systems. Although there is a growing body of literature in physical
      therapy ethics knowledge, including clinical obligations and underlying
      philosophical principles, less is known about the unique ethical issues that
      physical therapists encounter, and how and why they make ethical decisions. As
      moral agents, physical therapists are required to make autonomous clinical and
      ethical decisions based on connections and relationships with their patients,
      other health care team members, and health institutions and policies. This
      article identifies specific ethical dimensions of physical therapist practice and
      highlights the development and focus of ethics knowledge in physical therapy over
      the last several decades. An applied ethics model, called the "active engagement 
      model," is proposed to integrate clinical and ethical dimensions of practice with
      the theoretical knowledge and literature about ethics. The active engagement
      model has 3 practical steps: to listen actively, to think reflexively, and to
      reason critically. The model focuses on the underlying skills, attitudes, and
      actions that are required to build a sense of moral agency and purpose within
      physical therapist practice and to decrease gaps between the ethical dimensions
      of physical therapist practice and physical therapy ethics knowledge and
      scholarship. A clinical case study is provided to illustrate how the ethics
      engagement model might be used to analyze and provide insight into the ethical
      dimensions of physical therapist practice.
FAU - Delany, Clare M
AU  - Delany CM
AD  - Department of Physiotherapy, School of Health Sciences, The University of
      Melbourne, Parkville 3010, Melbourne, Victoria, Australia.
      c.delany@unimelb.edu.au
FAU - Edwards, Ian
AU  - Edwards I
FAU - Jensen, Gail M
AU  - Jensen GM
FAU - Skinner, Elizabeth
AU  - Skinner E
LA  - eng
PT  - Journal Article
DEP - 20100506
PL  - United States
TA  - Phys Ther
JT  - Physical therapy
JID - 0022623
SB  - IM
CIN - Phys Ther. 2010 Jul;90(7):1078-80; author reply 1081-2. PMID: 20595191
MH  - Communication
MH  - *Ethics, Clinical
MH  - Goals
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Physical Therapy Modalities/*standards
MH  - Physical Therapy Specialty/*standards
MH  - Professional-Patient Relations
MH  - Thinking
EDAT- 2010/05/08 06:00
MHDA- 2010/08/14 06:00
CRDT- 2010/05/08 06:00
PHST- 2010/05/08 06:00 [entrez]
PHST- 2010/05/08 06:00 [pubmed]
PHST- 2010/08/14 06:00 [medline]
AID - ptj.20090379 [pii]
AID - 10.2522/ptj.20090379 [doi]
PST - ppublish
SO  - Phys Ther. 2010 Jul;90(7):1068-78. doi: 10.2522/ptj.20090379. Epub 2010 May 6.


PMID- 20448008
OWN - NLM
STAT- MEDLINE
DCOM- 20100818
LR  - 20100507
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 5
DP  - 2010 May
TI  - Forensic DNA databases: genetic testing as a societal choice.
PG  - 319-20
LID - 10.1136/jme.2009.033829 [doi]
AB  - In this brief report, the authors argue that while a lot of concerns about
      forensic DNA databases have been raised using arguments from biomedical ethics,
      these databases are used in a complete different context from other biomedical
      tools. Because they are used in the struggle against crime, the decision to
      create or store a genetic profile cannot be left to the individual. Instead, this
      decision is made by officials of a society. These decisions have to be based on a
      policy that is the concretisation of some of society's most fundamental ideas
      about its own nature and function. Individuals wanting to influence these
      decisions have to try to influence this policy, within the bounds of a state's
      own self-concept. This article is an attempt to reorient the discussion about
      forensic DNA databases from a biomedical debate to a more political-philosophical
      one.
FAU - Patyn, Annemie
AU  - Patyn A
AD  - Katholieke Universiteit Leuven, Centre for Biomedical Ethics and Law,
      Kapucijnenvoer 35d bus 7001, Leuven 3000, Belgium.
FAU - Dierickx, Kris
AU  - Dierickx K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - *DNA
MH  - Databases, Nucleic Acid/*ethics
MH  - *Ethics, Medical
MH  - Forensic Sciences/*ethics
MH  - Genetic Testing/*ethics
MH  - Humans
MH  - Philosophy, Medical
MH  - *Public Opinion
EDAT- 2010/05/08 06:00
MHDA- 2010/08/19 06:00
CRDT- 2010/05/08 06:00
PHST- 2010/05/08 06:00 [entrez]
PHST- 2010/05/08 06:00 [pubmed]
PHST- 2010/08/19 06:00 [medline]
AID - 36/5/319 [pii]
AID - 10.1136/jme.2009.033829 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 May;36(5):319-20. doi: 10.1136/jme.2009.033829.


PMID- 20448007
OWN - NLM
STAT- MEDLINE
DCOM- 20100818
LR  - 20151119
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 5
DP  - 2010 May
TI  - Moral distress related to ethical dilemmas among Spanish podiatrists.
PG  - 310-4
LID - 10.1136/jme.2009.034322 [doi]
AB  - OBJECTIVES: To describe the distress experienced by Spanish podiatrists related
      to ethical dilemmas, organisational matters, and lack of resources. DESIGN: A
      2008 email survey of a representative sample of 485 Spanish podiatrists
      presenting statements about different ethical dilemmas, values and goals at the
      workplace. RESULTS: The response rate was 44.8%. Of all the respondents, 57%
      described sometimes having to act against their own conscience as distressing.
      Time constraints is the main cause of moral distress (67%) and 58% of respondents
      said that they found it distressing that patients have long waits for treatment. 
      Distress related to inadequate treatment due to economical constraints or
      ineffectiveness was described by 60% of the podiatrists. Another 51% reported
      that time spent on administration and documentation is distressing. Female
      doctors experienced more distress than their male colleagues. Last, 36% of
      respondents reported that their workplace lacked strategies for dealing with
      ethical dilemmas. CONCLUSION: These study results identify moral distress among
      Spanish podiatrists mainly related to time constraints, patient demands and lack 
      of resources. Moral distress varies with sex and age. Organisational strategies
      such as moral deliberation and responsive evaluation offer the potential to
      address moral distress.
FAU - Losa Iglesias, Marta Elena
AU  - Losa Iglesias ME
AD  - Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, Madrid, Spain.
      marta.losa@urjc.es
FAU - Becerro de Bengoa Vallejo, Ricardo
AU  - Becerro de Bengoa Vallejo R
FAU - Salvadores Fuentes, Paloma
AU  - Salvadores Fuentes P
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Adult
MH  - Aged
MH  - Bioethical Issues
MH  - Delivery of Health Care/ethics
MH  - *Ethics, Medical
MH  - Female
MH  - Goals
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Moral Obligations
MH  - Podiatry/*ethics
MH  - Spain
MH  - Stress, Psychological/*etiology
MH  - Surveys and Questionnaires
MH  - Workplace
EDAT- 2010/05/08 06:00
MHDA- 2010/08/19 06:00
CRDT- 2010/05/08 06:00
PHST- 2010/05/08 06:00 [entrez]
PHST- 2010/05/08 06:00 [pubmed]
PHST- 2010/08/19 06:00 [medline]
AID - 36/5/310 [pii]
AID - 10.1136/jme.2009.034322 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 May;36(5):310-4. doi: 10.1136/jme.2009.034322.


PMID- 20448006
OWN - NLM
STAT- MEDLINE
DCOM- 20100818
LR  - 20100507
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 5
DP  - 2010 May
TI  - Assisted suicide and the killing of people? Maybe. Physician-assisted suicide and
      the killing of patients? No: the rejection of Shaw's new perspective on
      euthanasia.
PG  - 306-9
LID - 10.1136/jme.2009.033118 [doi]
AB  - David Shaw presents a new argument to support the old claim that there is not a
      significant moral difference between killing and letting die and, by implication,
      between active and passive euthanasia. He concludes that doctors should not make 
      a distinction between them. However, whether or not killing and letting die are
      morally equivalent is not as important a question as he suggests. One can justify
      legal distinctions on non-moral grounds. One might oppose physician-assisted
      suicide and active euthanasia when performed by doctors on patients whether or
      not one is in favour of the legalisation of assisted suicide and active
      euthanasia. Furthermore, one can consider particular actions to be contrary to
      appropriate professional conduct even in the absence of legal and ethical
      objections to them. Someone who wants to die might want only a doctor to kill him
      or to help him to kill himself. However, we are not entitled to everything that
      we want in life or death. A doctor cannot always fittingly provide all that a
      patient wants or needs. It is appropriate that doctors provide their expert
      advice with regard to the performance of active euthanasia but they can and
      should do so while, qua doctors, they remain hors de combat.
FAU - McLachlan, Hugh V
AU  - McLachlan HV
AD  - School of Law and Social Sciences, Glasgow Caledonian University, Cowcaddens
      Road, Glasgow G4 0BA, UK. H.McLachlan@gcal.ac.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Ethical Theory
MH  - *Ethics, Medical
MH  - Euthanasia, Active/*ethics
MH  - Euthanasia, Passive/*ethics
MH  - Humans
MH  - Moral Obligations
MH  - Philosophy, Medical
MH  - Public Policy
MH  - Suicide, Assisted/*ethics/legislation & jurisprudence
EDAT- 2010/05/08 06:00
MHDA- 2010/08/19 06:00
CRDT- 2010/05/08 06:00
PHST- 2010/05/08 06:00 [entrez]
PHST- 2010/05/08 06:00 [pubmed]
PHST- 2010/08/19 06:00 [medline]
AID - 36/5/306 [pii]
AID - 10.1136/jme.2009.033118 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 May;36(5):306-9. doi: 10.1136/jme.2009.033118.


PMID- 20448005
OWN - NLM
STAT- MEDLINE
DCOM- 20100818
LR  - 20100507
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 5
DP  - 2010 May
TI  - Selling orthodontic need: innocent business decision or guilty pleasure?
PG  - 275-8
LID - 10.1136/jme.2009.033761 [doi]
AB  - The principal objective for most patients seeking orthodontic services is a
      detectable improvement in their dentofacial appearance. Orthodontic treatment, in
      the mind of the patient, is something that makes you look better, feel better
      about yourself, and perhaps enhances your social possibilities, ie, to find a
      companion or make a positive impression during a job interview. Orthodontics, as 
      a speciality, has collectively advanced the idea that enhanced occlusion (bite)
      improves the health and longevity of the dentition, and as a result many patients
      seeking orthodontic services affirm that their secondary goal of treatment is an 
      oral health benefit. It would appear that there is some disparity between the
      end-user of orthodontic services and the orthodontic provider's perception of
      what constitutes orthodontic need. The aim of this paper is to examine two
      contrasting models that characterise how dentists 'sell' orthodontic services to 
      patients and to discuss the conflict between professional ethics, practice
      management and evidence-based decision-making in orthodontic practice.
FAU - Ackerman, Marc Bernard
AU  - Ackerman MB
AD  - Clinical Orthodontic Research, Jacksonville University School of Orthodontics,
      2800 University Boulevard N, Jacksonville, FL 32256, USA. ackersmile@aol.com
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Attitude of Health Personnel
MH  - Decision Making/ethics
MH  - Dentists/psychology
MH  - Esthetics, Dental
MH  - *Ethics, Dental
MH  - Evidence-Based Medicine
MH  - Health Promotion/ethics
MH  - Humans
MH  - Malocclusion/rehabilitation
MH  - Oral Health
MH  - Orthodontics, Corrective/*ethics
MH  - Practice Management, Dental/ethics
EDAT- 2010/05/08 06:00
MHDA- 2010/08/19 06:00
CRDT- 2010/05/08 06:00
PHST- 2010/05/08 06:00 [entrez]
PHST- 2010/05/08 06:00 [pubmed]
PHST- 2010/08/19 06:00 [medline]
AID - 36/5/275 [pii]
AID - 10.1136/jme.2009.033761 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 May;36(5):275-8. doi: 10.1136/jme.2009.033761.


PMID- 20448004
OWN - NLM
STAT- MEDLINE
DCOM- 20100818
LR  - 20100507
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 5
DP  - 2010 May
TI  - Is supervised community treatment ethically justifiable?
PG  - 271-4
LID - 10.1136/jme.2009.033720 [doi]
AB  - Ethical viewpoints for and against the use of supervised community treatment
      (SCT), also known as outpatient commitment and community treatment orders, are
      examined. The perspectives of writers on civil liberties are considered. This
      paper argues that while civil liberties are an important concern SCT is ethically
      justifiable in the circumscribed population of 'revolving door' patients it
      applies to. This is on the grounds that it enables individuals to actualise their
      positive liberty. The issue of insight into mental illness is also considered and
      it is concluded that a further argument in favour of SCT comes from evidence that
      insight relates to neurobiological deficits. Limits to the ethical justifiability
      of SCT are considered with reference to individuals with substance dependency.
      The paper concludes that SCT is ethically permissible only in those with severe
      mental illness who have a history of losing capacity to consent to treatment
      and/or admission.
FAU - Dale, Eric
AU  - Dale E
AD  - Mental Health Department, Bassetlaw Hospital, Kilton Hill, Worksop,
      Nottinghamshire S81 0BD, UK. eric.dale@nottshc.nhs.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Civil Rights/*ethics
MH  - Commitment of Mentally Ill/*legislation & jurisprudence
MH  - *Community Mental Health Services/ethics/legislation & jurisprudence
MH  - England
MH  - Ethics, Medical
MH  - Hospitalization/statistics & numerical data
MH  - Humans
MH  - Mandatory Programs/*ethics
MH  - Mental Disorders/*therapy
MH  - Wales
EDAT- 2010/05/08 06:00
MHDA- 2010/08/19 06:00
CRDT- 2010/05/08 06:00
PHST- 2010/05/08 06:00 [entrez]
PHST- 2010/05/08 06:00 [pubmed]
PHST- 2010/08/19 06:00 [medline]
AID - 36/5/271 [pii]
AID - 10.1136/jme.2009.033720 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 May;36(5):271-4. doi: 10.1136/jme.2009.033720.


PMID- 20447812
OWN - NLM
STAT- MEDLINE
DCOM- 20101029
LR  - 20110127
IS  - 1769-664X (Electronic)
IS  - 0929-693X (Linking)
VI  - 17
IP  - 7
DP  - 2010 Jul
TI  - [Ethical dilemma in neonatology: a continuing debate].
PG  - 997-9
LID - 10.1016/j.arcped.2010.03.018 [doi]
FAU - Dageville, C
AU  - Dageville C
FAU - Grassin, M
AU  - Grassin M
LA  - fre
PT  - Editorial
TT  - Dilemmes ethiques en neonatologie: un debat a poursuivre.
DEP - 20100505
PL  - France
TA  - Arch Pediatr
JT  - Archives de pediatrie : organe officiel de la Societe francaise de pediatrie
JID - 9421356
SB  - IM
CIN - Arch Pediatr. 2011 Jan;18(1):95-6; author reply 96. PMID: 21130630
MH  - *Ethics, Medical
MH  - Euthanasia/ethics/legislation & jurisprudence
MH  - Human Rights
MH  - Humans
MH  - Infant, Newborn
MH  - *Neonatology
MH  - Parents
MH  - Physician's Role
MH  - Value of Life
MH  - Withholding Treatment
EDAT- 2010/05/08 06:00
MHDA- 2010/10/30 06:00
CRDT- 2010/05/08 06:00
PHST- 2009/12/19 00:00 [received]
PHST- 2010/03/31 00:00 [accepted]
PHST- 2010/05/08 06:00 [entrez]
PHST- 2010/05/08 06:00 [pubmed]
PHST- 2010/10/30 06:00 [medline]
AID - S0929-693X(10)00154-5 [pii]
AID - 10.1016/j.arcped.2010.03.018 [doi]
PST - ppublish
SO  - Arch Pediatr. 2010 Jul;17(7):997-9. doi: 10.1016/j.arcped.2010.03.018. Epub 2010 
      May 5.


PMID- 20447311
OWN - NLM
STAT- MEDLINE
DCOM- 20100803
LR  - 20101118
IS  - 1526-4637 (Electronic)
IS  - 1526-2375 (Linking)
VI  - 11
IP  - 3
DP  - 2010 Mar
TI  - Intractable end-of-life suffering and the ethics of palliative sedation: a
      commentary on Cassell and Rich.
PG  - 440-1; discussion 442
LID - 10.1111/j.1526-4637.2010.00798.x [doi]
FAU - Jansen, Lynn A
AU  - Jansen LA
AD  - The John J. Conley Center for Ethics St. Vincent's, Manhattan New York, New York,
      USA.
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - England
TA  - Pain Med
JT  - Pain medicine (Malden, Mass.)
JID - 100894201
RN  - 0 (Hypnotics and Sedatives)
SB  - IM
CON - Pain Med. 2010 Mar;11(3):435-8. PMID: 20088855
MH  - Humans
MH  - Hypnotics and Sedatives/*therapeutic use
MH  - Mind-Body Relations, Metaphysical
MH  - *Pain
MH  - Pain, Intractable/therapy
MH  - Palliative Care/*ethics
MH  - Terminal Care/*ethics
MH  - Terminology as Topic
EDAT- 2010/05/08 06:00
MHDA- 2010/08/04 06:00
CRDT- 2010/05/08 06:00
PHST- 2010/05/08 06:00 [entrez]
PHST- 2010/05/08 06:00 [pubmed]
PHST- 2010/08/04 06:00 [medline]
AID - PME798 [pii]
AID - 10.1111/j.1526-4637.2010.00798.x [doi]
PST - ppublish
SO  - Pain Med. 2010 Mar;11(3):440-1; discussion 442. doi:
      10.1111/j.1526-4637.2010.00798.x.


PMID- 20446993
OWN - NLM
STAT- MEDLINE
DCOM- 20100812
LR  - 20211020
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 38
IP  - 1
DP  - 2010 Spring
TI  - Currents in contemporary ethics. Malpractice immunity for volunteer physicians in
      Public Health Emergencies: adding insult to injury.
PG  - 149-53
LID - 10.1111/j.1748-720X.2010.00475.x [doi]
FAU - Rothstein, Mark A
AU  - Rothstein MA
AD  - University of Louisville School of Medicine, Kentucky, USA.
      mark.rothstein@louisville.edu
LA  - eng
GR  - P30 ES014443/ES/NIEHS NIH HHS/United States
GR  - P30 ES014443-04/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Disaster Planning/*legislation & jurisprudence
MH  - Emergency Medical Services/*ethics/*legislation & jurisprudence
MH  - Humans
MH  - Malpractice/*legislation & jurisprudence
MH  - Public Policy
MH  - United States
MH  - Volunteers/*legislation & jurisprudence
PMC - PMC3032940
MID - NIHMS264882
EDAT- 2010/05/08 06:00
MHDA- 2010/08/13 06:00
CRDT- 2010/05/08 06:00
PHST- 2010/05/08 06:00 [entrez]
PHST- 2010/05/08 06:00 [pubmed]
PHST- 2010/08/13 06:00 [medline]
AID - JLME475 [pii]
AID - 10.1111/j.1748-720X.2010.00475.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2010 Spring;38(1):149-53. doi:
      10.1111/j.1748-720X.2010.00475.x.


PMID- 20446992
OWN - NLM
STAT- MEDLINE
DCOM- 20100812
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 38
IP  - 1
DP  - 2010 Spring
TI  - The 2008 Declaration of Helsinki - first among equals in research ethics?
PG  - 143-8
LID - 10.1111/j.1748-720X.2010.00474.x [doi]
AB  - The World Medical Association's (WMA) Declaration of Helsinki is one of the most 
      important and influential international research ethics documents. Its most
      recent 2008 version declares unprecedented universal primacy over all existing
      national or international ethical, legal, or regulatory requirements. This
      self-proclaimed status as a set of minimal ethical standards raises important
      questions about the Declaration's appropriate normative status. The present paper
      argues that the new claim of ethical primacy is problematic and makes the
      Declaration unnecessarily vulnerable to criticism. Future revisions of the
      Declaration should therefore remove this claim and strengthen the document,
      first, by clarifying its normative status as a set of strong default
      recommendations, to be followed unless there is compelling ethical reason to do
      otherwise; and second, by improving the substance of the Declaration through
      further precision, specification, and argument.
FAU - Rid, Annette
AU  - Rid A
AD  - Department of Bioethics, National Institutes of Health, University of Zurich,
      Switzerland.
FAU - Schmidt, Harald
AU  - Schmidt H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Dissent and Disputes
MH  - *Helsinki Declaration
MH  - Humans
MH  - International Cooperation
EDAT- 2010/05/08 06:00
MHDA- 2010/08/13 06:00
CRDT- 2010/05/08 06:00
PHST- 2010/05/08 06:00 [entrez]
PHST- 2010/05/08 06:00 [pubmed]
PHST- 2010/08/13 06:00 [medline]
AID - JLME474 [pii]
AID - 10.1111/j.1748-720X.2010.00474.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2010 Spring;38(1):143-8. doi: 10.1111/j.1748-720X.2010.00474.x.


PMID- 20446991
OWN - NLM
STAT- MEDLINE
DCOM- 20100812
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 38
IP  - 1
DP  - 2010 Spring
TI  - Physicians' "right of conscience"- beyond politics.
PG  - 134-42
LID - 10.1111/j.1748-720X.2010.00473.x [doi]
AB  - During the past few months, the discussion over the physicians' "Right of
      Conscience" (ROC) has been on the rise. The intervention of politics in this
      issue shifts the discussion to a very specific and narrow area, namely the
      "reproductive health laws" which bear well-known predisposing attitudes. In this 
      article, the physician's ROC is discussed in the context in which it naturally
      belongs: the Patient Physician Relationship (PPR). I suggest that the physicians'
      rights demand is a comprehensible, predictable, and even inevitable step as part 
      of the "evolution" of the PPR. Thus, the most appropriate way to comprehend and
      tackle the demand for physicians' ROC is within the context of medical
      professionalism. While searching for practical solutions to the "reproductive
      health" problems, there is a need to recognize the ethical and practical
      implications of the change in the PPR and balance between patient and physician
      rights.
FAU - Gold, Azgad
AU  - Gold A
AD  - Division of Law, Ethics and Psychiatry, Department of Psychiatry, Columbia
      University, NY, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - *Conscience
MH  - Humans
MH  - Patient Rights/ethics/legislation & jurisprudence
MH  - Physician-Patient Relations/*ethics
MH  - Physicians/*ethics
MH  - *Professional Autonomy
MH  - Refusal to Treat/*ethics/*legislation & jurisprudence
MH  - United States
EDAT- 2010/05/08 06:00
MHDA- 2010/08/13 06:00
CRDT- 2010/05/08 06:00
PHST- 2010/05/08 06:00 [entrez]
PHST- 2010/05/08 06:00 [pubmed]
PHST- 2010/08/13 06:00 [medline]
AID - JLME473 [pii]
AID - 10.1111/j.1748-720X.2010.00473.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2010 Spring;38(1):134-42. doi:
      10.1111/j.1748-720X.2010.00473.x.


PMID- 20446989
OWN - NLM
STAT- MEDLINE
DCOM- 20100812
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 38
IP  - 1
DP  - 2010 Spring
TI  - The management of incidental findings in neuro-imaging research: framework and
      recommendations.
PG  - 117-26
LID - 10.1111/j.1748-720X.2010.00471.x [doi]
AB  - This paper addresses the question of how incidental findings (IFs) in clinical
      research should be managed by researchers, focusing in detail on IFs discovered
      in neuroimaging research. It begins by engaging the larger research ethics issue 
      of whether researchers have any obligations of clinical care to participants, and
      assesses the content and merits of one particular framework for answering this
      question, Richardson and Belsky's ancillary care model. From here the paper
      develops an organizational structure for integrating the ancillary care model
      with existing research ethics standards, with the aim of better understanding
      their respective domains. It makes a distinction between incidental findings that
      are anticipated by informed consent documents, and those that are unanticipated, 
      arguing that this distinction is critical for evaluating researcher obligations. 
      Finally, it takes on the issue of incidental findings in neuroimaging research,
      translating the standards discussed into recommendations for both unanticipated
      and anticipated findings.
FAU - Rangel, Erica K
AU  - Rangel EK
AD  - St. Louis University, MO, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Diagnostic Imaging/*ethics
MH  - Disclosure/ethics
MH  - *Ethics, Research
MH  - Humans
MH  - *Incidental Findings
MH  - Moral Obligations
MH  - Nervous System Diseases/*diagnosis
MH  - Professional-Patient Relations
MH  - Referral and Consultation/ethics
EDAT- 2010/05/08 06:00
MHDA- 2010/08/13 06:00
CRDT- 2010/05/08 06:00
PHST- 2010/05/08 06:00 [entrez]
PHST- 2010/05/08 06:00 [pubmed]
PHST- 2010/08/13 06:00 [medline]
AID - JLME471 [pii]
AID - 10.1111/j.1748-720X.2010.00471.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2010 Spring;38(1):117-26. doi:
      10.1111/j.1748-720X.2010.00471.x.


PMID- 20446987
OWN - NLM
STAT- MEDLINE
DCOM- 20100812
LR  - 20220317
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 38
IP  - 1
DP  - 2010 Spring
TI  - Aligning ethics with medical decision-making: the quest for informed patient
      choice.
PG  - 85-97
LID - 10.1111/j.1748-720X.2010.00469.x [doi]
AB  - Clinical evidence suggests that many patients undergo surgery that they would
      decline if fully informed. Failure to communicate the relevant risks, benefits,
      and alternatives of a procedure violates medical ethics and wastes medical
      resources. Integrating shared decision-making, a method of communication between 
      provider and patient, into medical decisions can satisfy physicians' ethical
      obligations and reduce unwanted procedures. This article proposes a three-step
      process for implementing a nationwide practice of shared decision-making: (1)
      create model integration programs; (2) provide legal incentives to ease the
      transition; and (3) incorporate shared decision-making into medical necessity
      determinations.
FAU - Moulton, Benjamin
AU  - Moulton B
AD  - Health Law at Harvard School of Public Health, MA, USA.
FAU - King, Jaime S
AU  - King JS
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - *Beneficence
MH  - Decision Making/*ethics
MH  - Disclosure/ethics/legislation & jurisprudence
MH  - Health Policy/legislation & jurisprudence
MH  - Humans
MH  - Informed Consent/*ethics/legislation & jurisprudence
MH  - *Patient Participation
MH  - Patient Preference
MH  - *Personal Autonomy
MH  - Physician-Patient Relations/*ethics
MH  - United States
EDAT- 2010/05/08 06:00
MHDA- 2010/08/13 06:00
CRDT- 2010/05/08 06:00
PHST- 2010/05/08 06:00 [entrez]
PHST- 2010/05/08 06:00 [pubmed]
PHST- 2010/08/13 06:00 [medline]
AID - JLME469 [pii]
AID - 10.1111/j.1748-720X.2010.00469.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2010 Spring;38(1):85-97. doi: 10.1111/j.1748-720X.2010.00469.x.


PMID- 20446985
OWN - NLM
STAT- MEDLINE
DCOM- 20100812
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 38
IP  - 1
DP  - 2010 Spring
TI  - Dreams and nightmares: practical and ethical issues for patients and physicians
      using personal health records.
PG  - 64-73
LID - 10.1111/j.1748-720X.2010.00467.x [doi]
AB  - Electronic health records for patients, personal health records (PHRs), have
      become increasingly popular among policy makers and purchasers, but uptake among 
      patients and physicians has been relatively slow. PHRs have varying uses that
      might make them more or less appealing to different stakeholders. The three core 
      uses for PHRs - promoting communication, data use, and patient responsibility -
      each raises a set of potential practical and financial dilemmas. But some ethical
      concerns are also at play, some of which are rarely recognized as values-based
      barriers to the use of PHRs. Recognizing these ethical issues, and addressing
      them explicitly in PHR design and policy making, would help PHRs to achieve their
      promise.
FAU - Wynia, Matthew
AU  - Wynia M
AD  - University of Chicago, IL, USA.
FAU - Dunn, Kyle
AU  - Dunn K
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Cost-Benefit Analysis
MH  - Electronic Health Records/*ethics/*organization & administration
MH  - Health Plan Implementation
MH  - Health Records, Personal/*ethics
MH  - Humans
MH  - Information Dissemination/*ethics
MH  - Quality of Health Care
MH  - United States
EDAT- 2010/05/08 06:00
MHDA- 2010/08/13 06:00
CRDT- 2010/05/08 06:00
PHST- 2010/05/08 06:00 [entrez]
PHST- 2010/05/08 06:00 [pubmed]
PHST- 2010/08/13 06:00 [medline]
AID - JLME467 [pii]
AID - 10.1111/j.1748-720X.2010.00467.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2010 Spring;38(1):64-73. doi: 10.1111/j.1748-720X.2010.00467.x.


PMID- 20446984
OWN - NLM
STAT- MEDLINE
DCOM- 20100812
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 38
IP  - 1
DP  - 2010 Spring
TI  - Ethics, information technology, and public health: new challenges for the
      clinician-patient relationship.
PG  - 58-63
LID - 10.1111/j.1748-720X.2010.00466.x [doi]
AB  - Increasingly widespread adoption of health information technology tools in
      clinical care increases interest in ethical and legal issues related to the use
      of these tools for public health and the effects of these uses on the
      clinician-patient relationship. It is argued that patients, clinicians, and
      society have generally uncontroversial duties to support civil society's public
      health mission, information technology supports this mission, and the effects of 
      automated and computerized public health surveillance are likely to have little
      if any effect on the clinician-patient relationship. It is also suggested,
      nevertheless, that electronic public health surveillance raises interesting and
      important ethical issues, some of which can be addressed if not resolved by
      empirical research, especially regarding patient preferences about secondary use 
      of health data and their moral obligation to contribute to population- based
      health.
FAU - Goodman, Kenneth W
AU  - Goodman KW
AD  - University of Miami, FL, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Confidentiality
MH  - Electronic Health Records/*ethics
MH  - Humans
MH  - *Information Dissemination
MH  - Physician-Patient Relations/*ethics
MH  - *Public Health
MH  - Social Responsibility
MH  - United States
EDAT- 2010/05/08 06:00
MHDA- 2010/08/13 06:00
CRDT- 2010/05/08 06:00
PHST- 2010/05/08 06:00 [entrez]
PHST- 2010/05/08 06:00 [pubmed]
PHST- 2010/08/13 06:00 [medline]
AID - JLME466 [pii]
AID - 10.1111/j.1748-720X.2010.00466.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2010 Spring;38(1):58-63. doi: 10.1111/j.1748-720X.2010.00466.x.


PMID- 20446980
OWN - NLM
STAT- MEDLINE
DCOM- 20100812
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 38
IP  - 1
DP  - 2010 Spring
TI  - The impact of web 2.0 on the doctor-patient relationship.
PG  - 17-26
LID - 10.1111/j.1748-720X.2010.00462.x [doi]
AB  - Web 2.0 innovations may enhance informed patient decision-making, but also raise 
      ethical concerns about inaccurate or misleading information, damage to the
      doctor-patient relationship, privacy and confidentiality, and health disparities.
      To increase the benefits and decrease the risks of these innovations, we
      recommend steps to help patients assess the quality of health information on the 
      Internet; promote constructive doctor-patient communication about new information
      technologies; and set standards for privacy and data security in
      patient-controlled health records and for point-of-service advertising.
FAU - Lo, Bernard
AU  - Lo B
AD  - University of California of San Fransico, CA, USA.
FAU - Parham, Lindsay
AU  - Parham L
LA  - eng
GR  - MH062246/MH/NIMH NIH HHS/United States
GR  - UL1 RR024131-01/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Diabetes Mellitus/therapy
MH  - *Health Records, Personal
MH  - *Health Services Accessibility
MH  - Humans
MH  - Information Services
MH  - *Internet
MH  - Male
MH  - Middle Aged
MH  - Patient Participation
MH  - *Physician-Patient Relations
MH  - Quality of Health Care
MH  - Self Care
MH  - Social Support
MH  - United States
EDAT- 2010/05/08 06:00
MHDA- 2010/08/13 06:00
CRDT- 2010/05/08 06:00
PHST- 2010/05/08 06:00 [entrez]
PHST- 2010/05/08 06:00 [pubmed]
PHST- 2010/08/13 06:00 [medline]
AID - JLME462 [pii]
AID - 10.1111/j.1748-720X.2010.00462.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2010 Spring;38(1):17-26. doi: 10.1111/j.1748-720X.2010.00462.x.


PMID- 20446978
OWN - NLM
STAT- MEDLINE
DCOM- 20100812
LR  - 20211020
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 38
IP  - 1
DP  - 2010 Spring
TI  - The Hippocratic bargain and health information technology.
PG  - 7-13
LID - 10.1111/j.1748-720X.2010.00460.x [doi]
AB  - The shift to longitudinal, comprehensive electronic health records (EHRs) means
      that any health care provider (e.g., dentist, pharmacist, physical therapist) or 
      third-party user of the EHR (e.g., employer, life insurer) will be able to access
      much health information of questionable clinical utility and possibly of great
      sensitivity. Genetic test results, reproductive health, mental health, substance 
      abuse, and domestic violence are examples of sensitive information that many
      patients would not want routinely available. The likely policy response is to
      give patients the ability to segment information in their EHRs and to sequester
      certain types of sensitive information, thereby limiting routine access to the
      totality of a patient's health record. This article explores the likely effect on
      the physician-patient relationship of patient-directed sequestration of sensitive
      health information, including the ethical and legal consequences.
FAU - Rothstein, Mark A
AU  - Rothstein MA
AD  - Health Policy and Law at the University of Louisville School of Medicine, LA,
      USA.
LA  - eng
GR  - P30 ES014443/ES/NIEHS NIH HHS/United States
GR  - P30 ES014443-04/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Confidentiality/*ethics/legislation & jurisprudence
MH  - Electronic Health Records/*ethics/legislation & jurisprudence
MH  - *Hippocratic Oath
MH  - Humans
MH  - Information Dissemination/ethics/legislation & jurisprudence
MH  - Physician-Patient Relations/*ethics
MH  - United States
PMC - PMC3032388
MID - NIHMS264875
EDAT- 2010/05/08 06:00
MHDA- 2010/08/13 06:00
CRDT- 2010/05/08 06:00
PHST- 2010/05/08 06:00 [entrez]
PHST- 2010/05/08 06:00 [pubmed]
PHST- 2010/08/13 06:00 [medline]
AID - JLME460 [pii]
AID - 10.1111/j.1748-720X.2010.00460.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2010 Spring;38(1):7-13. doi: 10.1111/j.1748-720X.2010.00460.x.


PMID- 20446976
OWN - NLM
STAT- MEDLINE
DCOM- 20110118
LR  - 20100507
IS  - 1445-5994 (Electronic)
IS  - 1444-0903 (Linking)
VI  - 40
IP  - 3
DP  - 2010 Mar
TI  - Clinical indicators: the role of patient in goal setting, evaluation and ethical 
      practice.
PG  - 244-6
LID - 10.1111/j.1445-5994.2009.02151.x [doi]
FAU - Myers, J
AU  - Myers J
LA  - eng
PT  - Comment
PT  - Letter
PL  - Australia
TA  - Intern Med J
JT  - Internal medicine journal
JID - 101092952
SB  - IM
CON - Intern Med J. 2009 Jun;39(6):347-51. PMID: 19580616
MH  - *Goals
MH  - Humans
MH  - Patient Care/*ethics/*standards
MH  - *Patient Participation/trends
MH  - Practice Guidelines as Topic/standards
EDAT- 2010/05/08 06:00
MHDA- 2011/01/19 06:00
CRDT- 2010/05/08 06:00
PHST- 2010/05/08 06:00 [entrez]
PHST- 2010/05/08 06:00 [pubmed]
PHST- 2011/01/19 06:00 [medline]
AID - IMJ2151 [pii]
AID - 10.1111/j.1445-5994.2009.02151.x [doi]
PST - ppublish
SO  - Intern Med J. 2010 Mar;40(3):244-6. doi: 10.1111/j.1445-5994.2009.02151.x.


PMID- 20446967
OWN - NLM
STAT- MEDLINE
DCOM- 20110118
LR  - 20161125
IS  - 1445-5994 (Electronic)
IS  - 1444-0903 (Linking)
VI  - 40
IP  - 3
DP  - 2010 Mar
TI  - Direct-to-consumer personal genome testing: ethical and regulatory issues that
      arise from wanting to 'know' your DNA.
PG  - 220-4
LID - 10.1111/j.1445-5994.2010.02190.x [doi]
AB  - Direct-to-consumer personal genome testing (DTC-PGT) screens a customer's genome 
      for the presence of single nucleotide polymorphisms that are reported to be
      associated with various diseases, disease risk factors and personal
      characteristics. The range of health risks covered by personal genome testing
      (PGT) includes cancer, heart disease, obesity, diabetes mellitus and
      osteoporosis. PGT also detects a range of other characteristics, such as alcohol 
      'flush reaction', eye colour, ear wax type and bitter taste perception.
      Information about ancestry and family history is also available. Although DTC-PGT
      is still a relatively new enterprise, the technology has the potential for rapid 
      expansion as it becomes more accessible to consumers who wish to obtain
      information about their genetic profile. This review provides an overview of the 
      broader ethical and regulatory issues raised by personal genome tests that are
      marketed directly to the public, and that purport to provide information about
      health risks. We discuss the emergence of DTC-PGT in Australia, and the possible 
      regulatory responses that may be taken to manage it.
FAU - Samuel, G N
AU  - Samuel GN
AD  - Centre for Values, Ethics and the Law in Medicine, The University of Sydney, and 
      Haematology Department, Westmead Hospital, Sydney, New South Wales, Australia.
      gabbysamuel@googlemail.com
FAU - Jordens, C F C
AU  - Jordens CF
FAU - Kerridge, I
AU  - Kerridge I
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Australia
TA  - Intern Med J
JT  - Internal medicine journal
JID - 101092952
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - *Community Participation
MH  - DNA/*genetics
MH  - Genetic Counseling/ethics/legislation & jurisprudence
MH  - Genetic Privacy/ethics/legislation & jurisprudence
MH  - Genetic Testing/*ethics/legislation & jurisprudence
MH  - Genome, Human/*genetics
MH  - Humans
MH  - Marketing of Health Services/*ethics/legislation & jurisprudence
RF  - 33
EDAT- 2010/05/08 06:00
MHDA- 2011/01/19 06:00
CRDT- 2010/05/08 06:00
PHST- 2010/05/08 06:00 [entrez]
PHST- 2010/05/08 06:00 [pubmed]
PHST- 2011/01/19 06:00 [medline]
AID - IMJ2190 [pii]
AID - 10.1111/j.1445-5994.2010.02190.x [doi]
PST - ppublish
SO  - Intern Med J. 2010 Mar;40(3):220-4. doi: 10.1111/j.1445-5994.2010.02190.x.


PMID- 20446413
OWN - NLM
STAT- MEDLINE
DCOM- 20100603
LR  - 20121115
IS  - 0253-0465 (Print)
IS  - 0253-0465 (Linking)
VI  - 103
IP  - 4
DP  - 2010
TI  - [Ethics education. A major challenge for being creative].
PG  - 48-50
FAU - Haberey-Knuessi, Veronique
AU  - Haberey-Knuessi V
AD  - HES, Haute-Ecole de Sante ARC, Neuchatel. Veronique.Haberey-Knuessi@he-arc.ch
LA  - fre
PT  - Journal Article
TT  - L'enseignement de l'ethique. Un defi majeur pour les formateurs.
PL  - Switzerland
TA  - Krankenpfl Soins Infirm
JT  - Krankenpflege. Soins infirmiers
JID - 8000153
MH  - Creativity
MH  - Education, Nursing, Graduate
MH  - *Ethics, Nursing
MH  - Humans
MH  - Nurse-Patient Relations
MH  - Nursing Care/standards
EDAT- 2010/05/08 06:00
MHDA- 2010/06/04 06:00
CRDT- 2010/05/08 06:00
PHST- 2010/05/08 06:00 [entrez]
PHST- 2010/05/08 06:00 [pubmed]
PHST- 2010/06/04 06:00 [medline]
PST - ppublish
SO  - Krankenpfl Soins Infirm. 2010;103(4):48-50.


PMID- 20445484
OWN - NLM
STAT- MEDLINE
DCOM- 20100915
LR  - 20131121
IS  - 1536-3694 (Electronic)
IS  - 0163-4356 (Linking)
VI  - 32
IP  - 3
DP  - 2010 Jun
TI  - Universal screening for prenatal alcohol exposure: a progress report of a pilot
      study in the region of Grey Bruce, Ontario.
PG  - 305-10
LID - 10.1097/FTD.0b013e3181dca381 [doi]
AB  - The main objective of this study is to evaluate the clinical utility of meconium 
      analysis for fatty acid ethyl esters as a universal screening tool intended for
      the detection of newborns at risk for fetal alcohol spectrum disorder. This will 
      be accomplished by assessing the rate of voluntary participation in a
      nonanonymous neonatal screening program and by determining the logistics of
      implementing the necessary follow-up and interventions as part of routine care.
      Additionally, this study will determine the predictive value of fatty acid ethyl 
      ester-positive meconium with regard to neurodevelopmental delays. This is an
      ongoing prospective cohort study. Written informed consent is sought from all
      Grey Bruce women delivering at participating birthing sites. Collected meconium
      samples are tested for fatty acid ethyl esters by headspace-solid-phase
      microextraction followed by gas chromatography-mass spectrometry. Children with
      positive results are followed up through an existing public health program
      involving regular home visits and assessments of developmental milestones by a
      public health nurse. These children and matched control subjects also undergo
      neurodevelopmental testing at 3 and 18 months of age by a clinical psychologist
      using Bayley Scales of Infant and Toddler Development. If delays are detected,
      the child is referred to diagnostic services and appropriate intervention
      programs. This study has been granted ethics approval and enrollment began in
      November 2008 at St. Joseph's Health Care in London, Ontario. The first positive 
      case has been identified and the follow-up is currently being conducted by the
      public health unit. The successful completing of this study will reveal the
      population's willingness to participate in a neonatal screening program for
      prenatal alcohol exposure and determine the costs, feasibility, and utility of
      implementing such programs in clinical practice.
FAU - Zelner, Irene
AU  - Zelner I
AD  - Division of Clinical Pharmacology & Toxicology, The Hospital for Sick Children,
      Toronto, Ontario, Canada.
FAU - Shor, Sarit
AU  - Shor S
FAU - Gareri, Joey
AU  - Gareri J
FAU - Lynn, Hazel
AU  - Lynn H
FAU - Roukema, Henry
AU  - Roukema H
FAU - Lum, Lisa
AU  - Lum L
FAU - Eisinga, Kirsten
AU  - Eisinga K
FAU - Nulman, Irena
AU  - Nulman I
FAU - Koren, Gideon
AU  - Koren G
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ther Drug Monit
JT  - Therapeutic drug monitoring
JID - 7909660
RN  - 0 (Esters)
RN  - 0 (Fatty Acids)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Alcoholism/*metabolism
MH  - Esters/analysis
MH  - Ethanol/*toxicity
MH  - Fatty Acids/analysis
MH  - Female
MH  - Fetal Alcohol Spectrum Disorders/*etiology/metabolism
MH  - Fetus/*drug effects
MH  - Gas Chromatography-Mass Spectrometry
MH  - Hospital Units
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - London
MH  - Mass Screening/*methods
MH  - Meconium/metabolism
MH  - Ontario
MH  - Pilot Projects
MH  - Pregnancy
MH  - Prenatal Care/legislation & jurisprudence
MH  - Program Development
EDAT- 2010/05/07 06:00
MHDA- 2010/09/16 06:00
CRDT- 2010/05/07 06:00
PHST- 2010/05/07 06:00 [entrez]
PHST- 2010/05/07 06:00 [pubmed]
PHST- 2010/09/16 06:00 [medline]
AID - 10.1097/FTD.0b013e3181dca381 [doi]
PST - ppublish
SO  - Ther Drug Monit. 2010 Jun;32(3):305-10. doi: 10.1097/FTD.0b013e3181dca381.


PMID- 20445091
OWN - NLM
STAT- MEDLINE
DCOM- 20100608
LR  - 20211020
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 107 Suppl 2
DP  - 2010 May 11
TI  - Colloquium paper: the difference of being human: morality.
PG  - 9015-22
LID - 10.1073/pnas.0914616107 [doi]
AB  - In The Descent of Man, and Selection in Relation to Sex, published in 1871,
      Charles Darwin wrote: "I fully ... subscribe to the judgment of those writers who
      maintain that of all the differences between man and the lower animals the moral 
      sense or conscience is by far the most important." I raise the question of
      whether morality is biologically or culturally determined. The question of
      whether the moral sense is biologically determined may refer either to the
      capacity for ethics (i.e., the proclivity to judge human actions as either right 
      or wrong), or to the moral norms accepted by human beings for guiding their
      actions. I propose that the capacity for ethics is a necessary attribute of human
      nature, whereas moral codes are products of cultural evolution. Humans have a
      moral sense because their biological makeup determines the presence of three
      necessary conditions for ethical behavior: (i) the ability to anticipate the
      consequences of one's own actions; (ii) the ability to make value judgments; and 
      (iii) the ability to choose between alternative courses of action. Ethical
      behavior came about in evolution not because it is adaptive in itself but as a
      necessary consequence of man's eminent intellectual abilities, which are an
      attribute directly promoted by natural selection. That is, morality evolved as an
      exaptation, not as an adaptation. Moral codes, however, are outcomes of cultural 
      evolution, which accounts for the diversity of cultural norms among populations
      and for their evolution through time.
FAU - Ayala, Francisco J
AU  - Ayala FJ
AD  - Department of Ecology and Evolutionary Biology, University of California, Irvine,
      CA 92697, USA. fjayala@uci.edu
LA  - eng
PT  - Journal Article
DEP - 20100505
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
SB  - IM
MH  - Adaptation, Psychological
MH  - *Biological Evolution
MH  - Cultural Characteristics
MH  - Culture
MH  - Ethics
MH  - Humans
MH  - Models, Biological
MH  - *Morals
MH  - Species Specificity
PMC - PMC3024030
EDAT- 2010/05/07 06:00
MHDA- 2010/06/09 06:00
CRDT- 2010/05/07 06:00
PHST- 2010/05/07 06:00 [entrez]
PHST- 2010/05/07 06:00 [pubmed]
PHST- 2010/06/09 06:00 [medline]
AID - 0914616107 [pii]
AID - 10.1073/pnas.0914616107 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2010 May 11;107 Suppl 2:9015-22. doi:
      10.1073/pnas.0914616107. Epub 2010 May 5.


PMID- 20444782
OWN - NLM
STAT- MEDLINE
DCOM- 20100923
LR  - 20100506
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 3
DP  - 2010 May
TI  - Leyla Dinc interviewed by Elizabeth Niven.
PG  - 404-6
LID - 10.1177/0969733010363782 [doi]
AB  - The intention behind this series of interviews with members of the Nursing Ethics
      Editorial Board by other Board members is to introduce members of the Board to
      readers. Here, Elizabeth Niven from New Zealand interviews Leyla Dinc, from
      Turkey. Elizabeth and Leyla have known each other for over five years. The
      interview was conducted by email.
FAU - Dinc, Leyla
AU  - Dinc L
LA  - eng
PT  - Interview
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - *Ethics, Nursing
MH  - *Faculty, Nursing/organization & administration
MH  - Humans
MH  - *Peer Review, Research
MH  - *Periodicals as Topic
MH  - Turkey
EDAT- 2010/05/07 06:00
MHDA- 2010/09/24 06:00
CRDT- 2010/05/07 06:00
PHST- 2010/05/07 06:00 [entrez]
PHST- 2010/05/07 06:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
AID - 17/3/404 [pii]
AID - 10.1177/0969733010363782 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 May;17(3):404-6. doi: 10.1177/0969733010363782.


PMID- 20444780
OWN - NLM
STAT- MEDLINE
DCOM- 20100923
LR  - 20191210
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 3
DP  - 2010 May
TI  - Applying an ethical decision-making tool to a nurse management dilemma.
PG  - 393-402
LID - 10.1177/0969733009355106 [doi]
AB  - This article considers ethical dilemmas that nurse managers may confront and
      suggests an ethical decision-making model that could be used as a tool for
      resolving such dilemmas. The focus of the article is on the question: Can nurse
      managers choose the ethically right solution in conflicting situations when
      nurses' rights collide with patients' rights to quality care in a world of
      cost-effective and economic constraint? Managers' responsibility is to ensure and
      facilitate a safe and ethical working environment in which nurses are able to
      give quality care to their patients. In nursing it is frequently declared that
      managers' main obligations are to patients' needs and their rights to receive
      quality care. However, managers' ethical responsibilities are not only to
      patients but also to the nurses working in their institution. This article
      describes a real (but disguised) situation from an Israeli health care context to
      illustrate the dilemmas that may arise. The question is posed of whether nurse
      managers can maintain patients' and nurses' rights and, at the same time, fulfill
      their obligation to the conflicting demands of the organization. The article also
      offers a way to solve conflict by using an ethical decision-making model.
FAU - Toren, Orly
AU  - Toren O
AD  - Hadassah Medical Center, Ein Kerem, Jerusalem, Israel. torly@hadassah.org.il
FAU - Wagner, Nurith
AU  - Wagner N
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Attitude of Health Personnel
MH  - Codes of Ethics
MH  - Conflict, Psychological
MH  - *Decision Making, Organizational
MH  - *Decision Support Techniques
MH  - Humans
MH  - Israel
MH  - *Models, Nursing
MH  - *Nurse Administrators/ethics/organization & administration
MH  - Nurse's Role/psychology
MH  - Nursing Staff, Hospital/ethics
MH  - Nursing, Supervisory/ethics
MH  - Patient Advocacy/ethics
MH  - Personnel Management
MH  - Principle-Based Ethics
MH  - Problem Solving
MH  - Professional Competence
MH  - Professional Impairment
MH  - Quality of Health Care/ethics
EDAT- 2010/05/07 06:00
MHDA- 2010/09/24 06:00
CRDT- 2010/05/07 06:00
PHST- 2010/05/07 06:00 [entrez]
PHST- 2010/05/07 06:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
AID - 17/3/393 [pii]
AID - 10.1177/0969733009355106 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 May;17(3):393-402. doi: 10.1177/0969733009355106.


PMID- 20444779
OWN - NLM
STAT- MEDLINE
DCOM- 20100923
LR  - 20171116
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 3
DP  - 2010 May
TI  - Literature review: status and trends of research ethics in Swedish nurses'
      dissertations.
PG  - 383-92
LID - 10.1177/0969733009355541 [doi]
AB  - Research ethics is increasingly formally regulated, but little is known about how
      ethical considerations are reported in dissertations. The aim of this literature 
      study was to describe the status and trends of ethical considerations in Swedish 
      doctoral dissertations written by registered nurses. A total of 77 dissertations 
      from 1987, 1997, and 2007 met the inclusion criteria and were analyzed by
      descriptive statistics. Ethical considerations were mostly overlooked in 1987,
      but almost ubiquitous by 2007. All dissertations in 2007, except one, had a
      section on ethical considerations; however, these were short, lacking in
      references, and short on content. The most common topic was informed consent and 
      approval from research ethics review boards, followed by confidentiality and
      ethical aspects of methodological issues. Our results imply that the quantity and
      quality of ethical considerations must be improved in order to assure ethical
      soundness for participants, patients, researchers, and society.
FAU - Kjellstrom, Sofia
AU  - Kjellstrom S
AD  - Institute of Gerontology, School of Health Sciences, Jonkoping University,
      Jonkoping, Sweden. sofia.kjellstrom@hhj.hj.se
FAU - Fridlund, Bengt
AU  - Fridlund B
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - *Academic Dissertations as Topic
MH  - Authorship
MH  - Confidentiality/ethics
MH  - Ethics Committees, Research/ethics
MH  - *Ethics, Research
MH  - Female
MH  - Humans
MH  - Informed Consent/ethics
MH  - Male
MH  - *Nursing Research/ethics/trends
MH  - Prospective Studies
MH  - Research Design
MH  - Sweden
RF  - 31
EDAT- 2010/05/07 06:00
MHDA- 2010/09/24 06:00
CRDT- 2010/05/07 06:00
PHST- 2010/05/07 06:00 [entrez]
PHST- 2010/05/07 06:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
AID - 17/3/383 [pii]
AID - 10.1177/0969733009355541 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 May;17(3):383-92. doi: 10.1177/0969733009355541.


PMID- 20444778
OWN - NLM
STAT- MEDLINE
DCOM- 20100923
LR  - 20220409
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 3
DP  - 2010 May
TI  - A comparison of problem-based learning and conventional teaching in nursing
      ethics education.
PG  - 373-82
LID - 10.1177/0969733009355380 [doi]
AB  - The aim of this study was to compare the learning effectiveness of peer tutored
      problem-based learning and conventional teaching of nursing ethics in Taiwan. The
      study adopted an experimental design. The peer tutored problem-based learning
      method was applied to an experimental group and the conventional teaching method 
      to a control group. The study sample consisted of 142 senior nursing students who
      were randomly assigned to the two groups. All the students were tested for their 
      nursing ethical discrimination ability both before and after the educational
      intervention. A learning satisfaction survey was also administered to both groups
      at the end of each course. After the intervention, both groups showed a
      significant increase in ethical discrimination ability. There was a statistically
      significant difference between the ethical discrimination scores of the two
      groups (P < 0.05), with the experimental group on average scoring higher than the
      control group. There were significant differences in satisfaction with
      self-motivated learning and critical thinking between the groups. Peer tutored
      problem-based learning and lecture-type conventional teaching were both effective
      for nursing ethics education, but problem-based learning was shown to be more
      effective. Peer tutored problem-based learning has the potential to enhance the
      efficacy of teaching nursing ethics in situations in which there are personnel
      and resource constraints.
FAU - Lin, Chiou-Fen
AU  - Lin CF
AD  - Taipei Medical University Shuang Ho Hospital, Taipei, Taiwan.
FAU - Lu, Meei-Shiow
AU  - Lu MS
FAU - Chung, Chun-Chih
AU  - Chung CC
FAU - Yang, Che-Ming
AU  - Yang CM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Analysis of Variance
MH  - Attitude of Health Personnel
MH  - Curriculum
MH  - Education, Nursing, Baccalaureate/*methods
MH  - Educational Measurement
MH  - Ethics, Nursing/*education
MH  - Humans
MH  - Motivation
MH  - Nursing Education Research
MH  - *Peer Group
MH  - Personal Satisfaction
MH  - Problem-Based Learning/*methods
MH  - Program Development
MH  - Program Evaluation
MH  - Students, Nursing/*psychology
MH  - Surveys and Questionnaires
MH  - Taiwan
MH  - Teaching/*methods
MH  - Thinking
EDAT- 2010/05/07 06:00
MHDA- 2010/09/24 06:00
CRDT- 2010/05/07 06:00
PHST- 2010/05/07 06:00 [entrez]
PHST- 2010/05/07 06:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
AID - 17/3/373 [pii]
AID - 10.1177/0969733009355380 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 May;17(3):373-82. doi: 10.1177/0969733009355380.


PMID- 20444776
OWN - NLM
STAT- MEDLINE
DCOM- 20100923
LR  - 20191210
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 3
DP  - 2010 May
TI  - Practical ethical theory for nurses responding to complexity in care.
PG  - 353-62
LID - 10.1177/0969733010361442 [doi]
AB  - In the context of health care system complexity, nurses need responsive
      leadership and organizational support to maintain intrinsic motivation, moral
      sensitivity and a caring stance in the delivery of patient care. The current
      complexity of nurses' work environment promotes decreases in work motivation and 
      moral satisfaction, thus creating motivational and ethical dissonance in
      practice. These and other work-related factors increase emotional stress and
      burnout for nurses, prompting both new and seasoned nurse professionals to leave 
      their current position, or even the profession. This article presents a
      theoretical conceptual model for professional nurses to review and make sense of 
      the ethical reasoning skills needed to maintain a caring stance in relation to
      the competing values that must coexist among nurses, health care administrators, 
      patients and families in the context of the complex health care work environments
      in which nurses are expected to practice. A model, Nurses' Ethical Reasoning
      Skills, is presented as a framework for nurses' thinking through and problem
      solving ethical issues in clinical practice in the context of complexity in
      health care.
FAU - Fairchild, Roseanne Moody
AU  - Fairchild RM
AD  - Indiana State University, Terre Haute, Indiana, USA.
      roseanne.fairchild@indstate.edu
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Adolescent
MH  - Conflict, Psychological
MH  - *Empathy
MH  - *Ethical Theory
MH  - Female
MH  - Health Facility Environment/organization & administration
MH  - Humans
MH  - Job Satisfaction
MH  - Leadership
MH  - *Models, Nursing
MH  - Morals
MH  - Nurse's Role/psychology
MH  - Nurse-Patient Relations/*ethics
MH  - Patient Advocacy/*ethics/psychology
MH  - Placenta Previa/nursing
MH  - Pregnancy
MH  - Problem Solving
MH  - *Professional Competence
MH  - Thinking
EDAT- 2010/05/07 06:00
MHDA- 2010/09/24 06:00
CRDT- 2010/05/07 06:00
PHST- 2010/05/07 06:00 [entrez]
PHST- 2010/05/07 06:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
AID - 17/3/353 [pii]
AID - 10.1177/0969733010361442 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 May;17(3):353-62. doi: 10.1177/0969733010361442.


PMID- 20444775
OWN - NLM
STAT- MEDLINE
DCOM- 20100923
LR  - 20100506
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 3
DP  - 2010 May
TI  - Research on ethics in nursing care for older people: a literature review.
PG  - 337-52
LID - 10.1177/0969733010361445 [doi]
AB  - The aim of this review was to analyse the empirical studies that focus on ethics 
      in nursing care for older people, scoping the need and areas for further study. A
      search of the MEDLINE and CINAHL databases (earliest to August 2009) was
      conducted using the the keywords: ethic* and nursing or care or caring and
      elderly or aged or older. After a four-stage process, 71 empirical articles were 
      included in the review, with informants ranging from elderly people to relatives,
      caregivers, managers and students in care settings. The review focuses on the
      concepts, contexts, methods and validity of these studies. Based on the analysis,
      the reviewed research seems to be fragmented and multifaceted, focussing on
      selected issues such as autonomy, self-determination and informed consent. No
      large research programs or research traditions were found so it was not possible 
      to draw any conclusions about suitable methods, study designs or instruments of
      measurement for use in this research area.
FAU - Suhonen, Riitta
AU  - Suhonen R
AD  - University of Turku, Turku, Finland. riisuh@utu.fi
FAU - Stolt, Minna
AU  - Stolt M
FAU - Launis, Veikko
AU  - Launis V
FAU - Leino-Kilpi, Helena
AU  - Leino-Kilpi H
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Aged
MH  - Empathy
MH  - Geriatric Nursing/*ethics/organization & administration
MH  - Humans
MH  - Informed Consent/ethics
MH  - Nurse's Role
MH  - Nursing Research/*organization & administration
MH  - Patient Advocacy/ethics
MH  - Personal Autonomy
MH  - Personhood
MH  - Philosophy, Nursing
MH  - Reproducibility of Results
MH  - Research Design
RF  - 87
EDAT- 2010/05/07 06:00
MHDA- 2010/09/24 06:00
CRDT- 2010/05/07 06:00
PHST- 2010/05/07 06:00 [entrez]
PHST- 2010/05/07 06:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
AID - 17/3/337 [pii]
AID - 10.1177/0969733010361445 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 May;17(3):337-52. doi: 10.1177/0969733010361445.


PMID- 20444774
OWN - NLM
STAT- MEDLINE
DCOM- 20100923
LR  - 20220321
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 3
DP  - 2010 May
TI  - Experiential learning of empathy in a care-ethics lab.
PG  - 325-36
LID - 10.1177/0969733010361440 [doi]
AB  - To generate empathy in the care of vulnerable older persons requires care
      providers to reflect critically on their care practices. Ethics education and
      training must provide them with tools to accomplish such critical reflection. It 
      must also create a pedagogical context in which good care can be taught and
      cultivated. The care-ethics lab 'sTimul' originated in 2008 in Flanders with the 
      stimulation of ethical reflection in care providers and care providers in
      training as its main goal. Also in 2008, sTimul commenced the organization of
      empathy sessions as an attempt to achieve this goal by simulation. The empathy
      session is a practical and fairly straightforward way of working to provoke care 
      providers and care providers in training to engage in ethical reflection.
      Characteristic of the empathy session in the care-ethics lab is the emphasis on
      experience as a basis for ethical reflection.
FAU - Vanlaere, Linus
AU  - Vanlaere L
AD  - sTimul: Care-Ethics Lab, Sint-Maartensplein 13, Moorsele, Belgium.
      linus.vanlaere@stimul.be
FAU - Coucke, Trees
AU  - Coucke T
FAU - Gastmans, Chris
AU  - Gastmans C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Activities of Daily Living
MH  - Aged
MH  - Attitude of Health Personnel
MH  - Belgium
MH  - *Clinical Competence
MH  - Curriculum
MH  - Education, Nursing, Baccalaureate/*organization & administration
MH  - *Empathy
MH  - Ethical Analysis
MH  - *Geriatric Nursing/education/ethics
MH  - Humans
MH  - Interior Design and Furnishings
MH  - Nurse's Role
MH  - Nurse-Patient Relations
MH  - Nursing Homes/organization & administration
MH  - Patient Simulation
MH  - Problem-Based Learning/*organization & administration
MH  - Program Development
MH  - Role Playing
MH  - Students, Nursing/psychology
MH  - Thinking
EDAT- 2010/05/07 06:00
MHDA- 2010/09/24 06:00
CRDT- 2010/05/07 06:00
PHST- 2010/05/07 06:00 [entrez]
PHST- 2010/05/07 06:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
AID - 17/3/325 [pii]
AID - 10.1177/0969733010361440 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 May;17(3):325-36. doi: 10.1177/0969733010361440.


PMID- 20444771
OWN - NLM
STAT- MEDLINE
DCOM- 20100923
LR  - 20220309
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 3
DP  - 2010 May
TI  - Dignity of older people in a nursing home: narratives of care providers.
PG  - 289-300
LID - 10.1177/0969733009355375 [doi]
AB  - The purpose of this study was to illuminate the ethically difficult situations
      experienced by care providers working in a nursing home. Individual interviews
      using a narrative approach were conducted. A phenomenological-hermeneutic method 
      developed for researching life experience was applied in the analysis. The
      findings showed that care providers experience ethical challenges in their
      everyday work. The informants in this study found the balance between the ideal, 
      autonomy and dignity to be a daily problem. They defined the culture they work in
      as not supportive. They also thought they were not being seen and heard in
      situations where they disagree with the basic values of the organization. The
      results are discussed in terms of Habermas's understanding of modern society.
      Care settings for elderly people obviously present ethical challenges,
      particularly in the case of those suffering from dementia. The care provider
      participants in this study expressed frustration and feelings of powerlessness.
      It is possible to understand their experiences in terms of Habermas's theory of
      modern society and the concept of the system's colonization of the life world.
FAU - Jakobsen, Rita
AU  - Jakobsen R
AD  - Lovisenberg Deaconal University College, Oslo, Norway. rita.jakobsen@ldh.no
FAU - Sorlie, Venke
AU  - Sorlie V
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - *Adaptation, Psychological
MH  - Aged
MH  - *Attitude of Health Personnel
MH  - Communication
MH  - Conflict, Psychological
MH  - Dementia/nursing
MH  - Frustration
MH  - Geriatric Nursing/ethics
MH  - Health Facility Environment/ethics
MH  - Humans
MH  - Narration
MH  - Norway
MH  - Nursing Homes/*ethics
MH  - Nursing Methodology Research
MH  - *Nursing Staff/ethics/psychology
MH  - Patient Advocacy/*ethics
MH  - *Personhood
MH  - Power, Psychological
MH  - Qualitative Research
MH  - Restraint, Physical/ethics/psychology
MH  - Surveys and Questionnaires
MH  - Workload/psychology
EDAT- 2010/05/07 06:00
MHDA- 2010/09/24 06:00
CRDT- 2010/05/07 06:00
PHST- 2010/05/07 06:00 [entrez]
PHST- 2010/05/07 06:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
AID - 17/3/289 [pii]
AID - 10.1177/0969733009355375 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 May;17(3):289-300. doi: 10.1177/0969733009355375.


PMID- 20444768
OWN - NLM
STAT- MEDLINE
DCOM- 20101217
LR  - 20100624
IS  - 1477-030X (Electronic)
IS  - 0269-2163 (Linking)
VI  - 24
IP  - 5
DP  - 2010 Jul
TI  - Reconciling informed consent and 'do no harm': ethical challenges in
      palliative-care research and practice in chronic obstructive pulmonary disease.
PG  - 469-72
LID - 10.1177/0269216310367536 [doi]
AB  - The challenges associated with patient-based research in palliative care are well
      documented. This paper focuses on the ethical challenges and discusses them in
      the context of a pilot study to explore the palliative-care needs of patients
      with moderate and severe chronic obstructive pulmonary disease. The main ethical 
      challenge encountered related to problems surrounding the use of terminology,
      specifically the terms 'palliative care' and 'chronic obstructive pulmonary
      disease'. The approving ethics committee specified that these terms be removed
      from all patient materials in order to protect patients from undue distress. The 
      impact of this ethical advice on patients' ability to give fully informed consent
      is discussed. This paper highlights a requirement for appropriately resourced and
      well-managed studies in palliative care, and identifies a need for the
      development of appropriate strategies in order to ensure the informed
      participation of patients with non-cancer diagnoses in palliative-care research.
FAU - Gardiner, Clare
AU  - Gardiner C
AD  - School of Nursing and Midwifery, University of Sheffield, Sheffield, UK.
      c.gardiner@sheffield.ac.uk
FAU - Barnes, Sarah
AU  - Barnes S
FAU - Small, Neil
AU  - Small N
FAU - Gott, Merryn
AU  - Gott M
FAU - Payne, Sheila
AU  - Payne S
FAU - Seamark, David
AU  - Seamark D
FAU - Halpin, David
AU  - Halpin D
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20100505
PL  - England
TA  - Palliat Med
JT  - Palliative medicine
JID - 8704926
SB  - IM
MH  - Clinical Trials as Topic/*ethics
MH  - *Ethics, Medical
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Palliative Care/*ethics/standards
MH  - Pilot Projects
MH  - Pulmonary Disease, Chronic Obstructive/*therapy
EDAT- 2010/05/07 06:00
MHDA- 2010/12/18 06:00
CRDT- 2010/05/07 06:00
PHST- 2010/05/07 06:00 [entrez]
PHST- 2010/05/07 06:00 [pubmed]
PHST- 2010/12/18 06:00 [medline]
AID - 0269216310367536 [pii]
AID - 10.1177/0269216310367536 [doi]
PST - ppublish
SO  - Palliat Med. 2010 Jul;24(5):469-72. doi: 10.1177/0269216310367536. Epub 2010 May 
      5.


PMID- 20444077
OWN - NLM
STAT- MEDLINE
DCOM- 20100920
LR  - 20100506
IS  - 1365-2923 (Electronic)
IS  - 0308-0110 (Linking)
VI  - 44
IP  - 4
DP  - 2010 Apr
TI  - Continuing professional development for general practitioners: supporting the
      development of professionalism.
PG  - 412-20
LID - 10.1111/j.1365-2923.2010.03620.x [doi]
AB  - OBJECTIVES: The profession of medicine has long been characterised by virtues
      such as authorisation, specialisation, autonomy, self-regulation and adherence to
      an ethical code of practice, and its complexity has granted it the privilege of
      self-regulation. Studies have shown continuing professional development (CPD) for
      general practitioners (GPs) to be most effective when it is set up within a
      multi-method design. This paper reports a research-based evaluation of a 2-year
      educational CPD project for 21 GPs. METHODS: The project focused on the issue of 
      'children in need' and was delivered through group supervision, teaching days, an
      e-portfolio, literature, newsletters and a desk checklist. A mixed-methods
      evaluation design was used. RESULTS: The GPs demonstrated an overall preference
      for supervision as an authentic method for self-directed professional development
      because it facilitated the creation of a common platform for relevant and useful 
      knowledge in the context of general practice. Other methods were perceived as
      less valuable for GPs' CPD. CONCLUSIONS: The results suggest that general
      practitioners need to establish a common platform of shared experiences before
      engaging in multi-professional CPD. Participation in the supervision allowed the 
      three groups of GPs to develop their professional skills, but left them with a
      desire for more training in establishing cooperative practices with their
      partners in care. The professional challenges discussed during the supervision
      sessions were important elements of the national GP Curriculum, but not all
      elements of professionalism were covered.
FAU - Tulinius, Charlotte
AU  - Tulinius C
AD  - St Edmund's College, Cambridge, UK. tulinius@sund.ku.dk
FAU - Holge-Hazelton, Bibi
AU  - Holge-Hazelton B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Med Educ
JT  - Medical education
JID - 7605655
SB  - IM
MH  - Clinical Competence/*standards
MH  - Denmark
MH  - Education, Medical, Continuing/*methods/standards
MH  - Educational Measurement/*methods/standards
MH  - Family Practice/*education
MH  - Humans
EDAT- 2010/05/07 06:00
MHDA- 2010/09/21 06:00
CRDT- 2010/05/07 06:00
PHST- 2010/05/07 06:00 [entrez]
PHST- 2010/05/07 06:00 [pubmed]
PHST- 2010/09/21 06:00 [medline]
AID - MED3620 [pii]
AID - 10.1111/j.1365-2923.2010.03620.x [doi]
PST - ppublish
SO  - Med Educ. 2010 Apr;44(4):412-20. doi: 10.1111/j.1365-2923.2010.03620.x.


PMID- 20443953
OWN - NLM
STAT- MEDLINE
DCOM- 20100809
LR  - 20211020
IS  - 1752-8062 (Electronic)
IS  - 1752-8054 (Linking)
VI  - 3
IP  - 1
DP  - 2010 Feb
TI  - Principles of human subjects protections applied in an opt-out, de-identified
      biobank.
PG  - 42-8
LID - 10.1111/j.1752-8062.2010.00175.x [doi]
AB  - BioVU, the Vanderbilt DNA Databank, is one of few biobanks that qualifies as
      non-human subjects research as determined by the local IRB and the federal Office
      of Human Research Protections (OHRP). BioVU accrues DNA samples extracted from
      leftover blood remaining from routine clinical testing. The resource is linked to
      a de-identified version of data extracted from an Electronic Medical Record (EMR)
      system, termed the Synthetic Device (SD), in which all personal identifiers have 
      been removed. Thus, there is no identifiable private information attached to the 
      records. The Belmont Report enumerates the importance of the boundary between
      practice and research, and three principles: Respect for Persons, Beneficence,
      and Justice, which constitute the essential ethical framework by which IRBs and
      ethics committees judge the risks and benefits of research involving human
      subjects. BioVU was developed by designing and implementing new procedures, for
      which there were no previously established methods, which are consistent with the
      principles of the Belmont Report. These included special oversight and
      governance, new informatics technologies, provisions to accommodate patients'
      preferences, as well as an extensive public education and communications
      component. Considerations of core principles and protections in the practical
      implementation of BioVU is the focus of this paper.
FAU - Pulley, Jill
AU  - Pulley J
AD  - Vanderbilt Institute for Clinical and Translational Research, Vanderbilt
      University School of Medicine, Nashville, Tennessee, USA.
      Jill.pulley@vanderbilt.edu
FAU - Clayton, Ellen
AU  - Clayton E
FAU - Bernard, Gordon R
AU  - Bernard GR
FAU - Roden, Dan M
AU  - Roden DM
FAU - Masys, Daniel R
AU  - Masys DR
LA  - eng
GR  - 5U01HG004603-02/HG/NHGRI NIH HHS/United States
GR  - UL1 RR024975-05/RR/NCRR NIH HHS/United States
GR  - KL2 RR024977/RR/NCRR NIH HHS/United States
GR  - UL1 RR024975/RR/NCRR NIH HHS/United States
GR  - 1 UL1 RR024975/RR/NCRR NIH HHS/United States
GR  - U01 HG004603-02/HG/NHGRI NIH HHS/United States
GR  - UL1 RR024975-04/RR/NCRR NIH HHS/United States
GR  - U01 HG004603/HG/NHGRI NIH HHS/United States
GR  - TL1 RR024978/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Clin Transl Sci
JT  - Clinical and translational science
JID - 101474067
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomedical Research/ethics
MH  - *Databases, Nucleic Acid
MH  - *Ethics, Medical
MH  - Female
MH  - Human Experimentation/*ethics/legislation & jurisprudence
MH  - Humans
MH  - Informed Consent
MH  - Male
MH  - Medical Records Systems, Computerized
MH  - Middle Aged
MH  - Models, Organizational
MH  - Risk
PMC - PMC3075971
MID - NIHMS281027
EDAT- 2010/05/07 06:00
MHDA- 2010/08/10 06:00
CRDT- 2010/05/07 06:00
PHST- 2010/05/07 06:00 [entrez]
PHST- 2010/05/07 06:00 [pubmed]
PHST- 2010/08/10 06:00 [medline]
AID - CTS175 [pii]
AID - 10.1111/j.1752-8062.2010.00175.x [doi]
PST - ppublish
SO  - Clin Transl Sci. 2010 Feb;3(1):42-8. doi: 10.1111/j.1752-8062.2010.00175.x.


PMID- 20443952
OWN - NLM
STAT- MEDLINE
DCOM- 20100809
LR  - 20211020
IS  - 1752-8062 (Electronic)
IS  - 1752-8054 (Linking)
VI  - 3
IP  - 1
DP  - 2010 Feb
TI  - The European and American use of exploratory approaches for first-in-human
      studies.
PG  - 38-41
LID - 10.1111/j.1752-8062.2010.00174.x [doi]
AB  - Exploratory approaches for first-in-human clinical studies have evolved over the 
      last few years and have stimulated the issuance of national regulatory guidances 
      in some European countries as well as the United States. With the increasing
      implementation of these approaches and the recent preparation of a multiregional 
      regulatory guidance (ICH M3 rev2), an exchange of experiences on the
      opportunities and challenges of exploratory clinical trials was desirable; thus, 
      a workshop focusing on the use of this clinical approach was planned and
      conducted in Lisbon, Portugal, March 18-19, 2009 sponsored by the Portuguese
      Health Authority (INFARMED) and DIA. The structure of the workshop focused in
      three main areas. Regulatory representatives from Portugal, Belgium, Germany, the
      United Kingdom and the United States formally reviewed their experiences. This
      was followed by a discussion on issues from an ethics review perspective as well 
      as an insight to the opportunities in the area of biologics. The industry
      perspective was presented by representatives from Merck, Pfizer, J&J, Novartis,
      Speedel, AstraZeneca, GSK, and Roche. Finally, through break out sessions, issues
      were identified to be addressed moving forward. It is the purpose of this paper
      to report on the outcome of this workshop.
FAU - Silva-Lima, Beatriz
AU  - Silva-Lima B
AD  - iMED, University of Lisbon, INFARMED, Lisbon, Portugal. beatrizlima@netcabo.pt
FAU - Carlson, David
AU  - Carlson D
FAU - Jones, David R
AU  - Jones DR
FAU - Laurie, David
AU  - Laurie D
FAU - Stahl, Elke
AU  - Stahl E
FAU - Maria, Vasco
AU  - Maria V
FAU - Janssens, Walter
AU  - Janssens W
FAU - Robinson, William T
AU  - Robinson WT
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Transl Sci
JT  - Clinical and translational science
JID - 101474067
RN  - 0 (Biological Products)
RN  - 0 (Drugs, Investigational)
SB  - IM
MH  - Biological Products/therapeutic use
MH  - Clinical Trials as Topic/ethics/legislation & jurisprudence/*trends
MH  - Drug Industry
MH  - Drugs, Investigational
MH  - Ethics, Medical
MH  - Europe
MH  - Humans
MH  - International Cooperation
MH  - Treatment Outcome
MH  - United States
PMC - PMC5439606
EDAT- 2010/05/07 06:00
MHDA- 2010/08/10 06:00
CRDT- 2010/05/07 06:00
PHST- 2010/05/07 06:00 [entrez]
PHST- 2010/05/07 06:00 [pubmed]
PHST- 2010/08/10 06:00 [medline]
AID - CTS174 [pii]
AID - 10.1111/j.1752-8062.2010.00174.x [doi]
PST - ppublish
SO  - Clin Transl Sci. 2010 Feb;3(1):38-41. doi: 10.1111/j.1752-8062.2010.00174.x.


PMID- 20443442
OWN - NLM
STAT- MEDLINE
DCOM- 20100610
LR  - 20161125
IS  - 0929-0273 (Print)
IS  - 0929-0273 (Linking)
VI  - 17
IP  - 2
DP  - 2010 Mar
TI  - Presumed consent in organ donation: is the duty finally upon us?
PG  - 149-64
AB  - In recent years there has been a renewed interest in presumed consent systems for
      organ donation. The U.K.'s Organ Donation (Presumed Consent and Safeguards) Bill 
      of 2004 proposed a sweeping change in the law in the form of an opt-out system
      for the donation of cadaver organs. The Organ Donation Task-force in 2008 later
      examined the idea of presumed consent at length, before concluding that our
      current organ procurement system needs a radical overhaul. Most recently, the
      Organ Donation (Presumed Consent) Bill of 2009 ("the 2009 Bill") provided the
      most comprehensive proposal yet for an opt-out organ donation system in the
      United Kingdom. Is it now time to take this controversial issue seriously? If the
      2009 Bill provides a window into the future, what practical and ethical
      difficulties will this new presumed consent legislation impart upon our current
      organ procurement system? This article will provide an overview of the previous
      attempts in the U.K. to implement an opt-out system for organ donation, before
      examining in detail the content of the 2009 Bill as a potential template for a
      new presumed consent law. Finally, some sweeping amendments to the 2009 Bill will
      be suggested, and it will be concluded that a new piece of legislation may change
      our national and international views of organ donation for the better.
FAU - Cherkassky, Lisa
AU  - Cherkassky L
AD  - Bradford University Law School, UK.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Eur J Health Law
JT  - European journal of health law
JID - 9431861
SB  - IM
MH  - Humans
MH  - Organ Transplantation/*legislation & jurisprudence
MH  - Presumed Consent/ethics/*legislation & jurisprudence
MH  - Tissue Donors/*legislation & jurisprudence
MH  - United Kingdom
EDAT- 2010/05/07 06:00
MHDA- 2010/06/11 06:00
CRDT- 2010/05/07 06:00
PHST- 2010/05/07 06:00 [entrez]
PHST- 2010/05/07 06:00 [pubmed]
PHST- 2010/06/11 06:00 [medline]
PST - ppublish
SO  - Eur J Health Law. 2010 Mar;17(2):149-64.


PMID- 20442654
OWN - NLM
STAT- MEDLINE
DCOM- 20100927
LR  - 20100623
IS  - 1531-7048 (Electronic)
IS  - 1065-6251 (Linking)
VI  - 17
IP  - 4
DP  - 2010 Jul
TI  - Evolution of induced pluripotent stem cell technology.
PG  - 276-80
LID - 10.1097/MOH.0b013e328339f2ee [doi]
AB  - PURPOSE OF REVIEW: Induced pluripotent stem cell (iPSC) technology, which uses
      defined transcription factors to reprogram somatic cells to become pluripotent
      cells, offers a significant technical simplicity and enables generation of
      patient-specific pluripotent stem cells with reduced ethical concerns. This
      review will focus on recent progresses in understanding of iPSCs and improved
      methods of generating iPSCs. RECENT FINDINGS: Whereas iPSCs generated from a
      variety of cell sources were found to be nearly identical functionally to
      embryonic stem cells, some differences were also identified and remain to be
      characterized. Meanwhile, new methods of generating iPSCs with minimal or no
      exogenous genetic modifications to cells have advanced rapidly. SUMMARY: iPSC
      technology provides unprecedented opportunities in biomedical research and
      regenerative medicine. However, there remain a great deal to learn about iPSC
      safety, the reprogramming mechanisms, and better ways to direct a specific
      reprogramming process. The iPSC field will flourish on its mechanistic studies,
      iPSC-based disease modeling, and identification of new small molecules that
      modulate reprogramming.
FAU - Zhou, Hongyan
AU  - Zhou H
AD  - Department of Chemistry, The Scripps Research Institute, La Jolla, California
      92037, USA.
FAU - Ding, Sheng
AU  - Ding S
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Hematol
JT  - Current opinion in hematology
JID - 9430802
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Cell Culture Techniques/methods/trends
MH  - *Cell Differentiation
MH  - Embryonic Stem Cells/*cytology/metabolism
MH  - Gene Transfer Techniques
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*cytology/metabolism
MH  - Pluripotent Stem Cells/*cytology/metabolism
MH  - Transcription Factors/genetics
RF  - 43
EDAT- 2010/05/06 06:00
MHDA- 2010/09/29 06:00
CRDT- 2010/05/06 06:00
PHST- 2010/05/06 06:00 [entrez]
PHST- 2010/05/06 06:00 [pubmed]
PHST- 2010/09/29 06:00 [medline]
AID - 10.1097/MOH.0b013e328339f2ee [doi]
PST - ppublish
SO  - Curr Opin Hematol. 2010 Jul;17(4):276-80. doi: 10.1097/MOH.0b013e328339f2ee.


PMID- 20442543
OWN - NLM
STAT- MEDLINE
DCOM- 20101103
LR  - 20181201
IS  - 0974-5181 (Electronic)
IS  - 0971-9784 (Linking)
VI  - 13
IP  - 2
DP  - 2010 May-Aug
TI  - Echocardiographic evaluation and comparison of the effects of isoflurane,
      sevoflurane and desflurane on left ventricular relaxation indices in patients
      with diastolic dysfunction.
PG  - 130-7
LID - 10.4103/0971-9784.62945 [doi]
AB  - This prospective randomized study aims to evaluate and compare the effects of
      isoflurane, sevoflurane and desflurane (study drugs) on left ventricular (LV)
      diastolic function in patients with impaired LV relaxation due to ischemic heart 
      disease using transesophageal Doppler echocardiography. After approval of the
      local ethics committee and informed consent, 45 patients scheduled for coronary
      artery bypass grafting surgery were enrolled in the study. Patients were selected
      by a preoperative Transthoracic Echocardiographic diagnosis of impaired
      relaxation or Grade 1 Diastolic Dysfunction. They randomly received fentanyl and 
      midazolam anesthesia with 1 MAC of isoflurane (n=16), sevoflurane (n=14) or
      desflurane (n=15). Hemodynamic parameters and TEE derived ventricular diastolic
      relaxation indices before and after the study drug administration were compared. 
      LV filling pressures were kept constant throughout the study period to exclude
      the effect of the loading conditions on diastolic function. Four patients in the 
      sevoflurane group and three in the desflurane group were excluded from the study,
      after baseline TEE examination revealed normal diastolic filling pattern. All the
      three study drugs significantly reduced the systemic vascular resistance index
      with a significant increase in cardiac index. Mean arterial pressure was reduced 
      by all the drugs, although the decrease was not statistically significant.
      Hemodynamic changes were comparable between all the three groups. In terms of LV 
      relaxation indices, all three agents led to a significant improvement in
      diastolic function. Transmitral and Tissue Doppler E/A and Em/Am ratios improved 
      significantly Transmitral and Tissue Doppler E/A and Em/Am ratios improved
      significantly accompanied by a significant decrease in deceleration time and
      isovolumetric relaxation time. The effect of all three agents on diastolic
      relaxation parameters was comparable. In conclusion , Isoflurane, sevoflurane and
      desflurane, do not appear to have a detrimental effect in patients with early
      diastolic dysfunction. On the contrary, these inhalational agents actually
      improve the LV relaxation. A significant reduction in afterload produced by these
      vapors can be a possible reason for these findings. The positive effect of these 
      inhalational agents on LV relaxation can have a profound effect on the
      perioperative anesthetic management of patients with diastolic dysfunction.
FAU - Sarkar, Subhendu
AU  - Sarkar S
AD  - Woodlands Hospital & Medical Research Center Ltd, India.
FAU - GuhaBiswas, Rahul
AU  - GuhaBiswas R
FAU - Rupert, Emmanuel
AU  - Rupert E
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - India
TA  - Ann Card Anaesth
JT  - Annals of cardiac anaesthesia
JID - 9815987
RN  - 0 (Anesthetics, Inhalation)
RN  - 0 (Methyl Ethers)
RN  - 38LVP0K73A (Sevoflurane)
RN  - CRS35BZ94Q (Desflurane)
RN  - CYS9AKD70P (Isoflurane)
SB  - IM
MH  - Anesthetics, Inhalation/*pharmacology
MH  - Desflurane
MH  - Echocardiography, Transesophageal
MH  - Hemodynamics/drug effects
MH  - Humans
MH  - Isoflurane/*analogs & derivatives/*pharmacology
MH  - Methyl Ethers/*pharmacology
MH  - Prospective Studies
MH  - Sevoflurane
MH  - Treatment Outcome
MH  - Ventricular Dysfunction, Left/diagnostic imaging/*drug therapy
MH  - Ventricular Function, Left/*drug effects/physiology
EDAT- 2010/05/06 06:00
MHDA- 2010/11/04 06:00
CRDT- 2010/05/06 06:00
PHST- 2010/05/06 06:00 [entrez]
PHST- 2010/05/06 06:00 [pubmed]
PHST- 2010/11/04 06:00 [medline]
AID - AnnCardAnaesth_2010_13_2_130_62945 [pii]
AID - 10.4103/0971-9784.62945 [doi]
PST - ppublish
SO  - Ann Card Anaesth. 2010 May-Aug;13(2):130-7. doi: 10.4103/0971-9784.62945.


PMID- 20441487
OWN - NLM
STAT- MEDLINE
DCOM- 20100728
LR  - 20220331
IS  - 1360-0567 (Electronic)
IS  - 0963-8237 (Linking)
VI  - 19
IP  - 3
DP  - 2010 Jun
TI  - Mental health users' experiences of being interviewed by another user in a
      research project. A qualitative study.
PG  - 237-42
LID - 10.3109/09638230903531084 [doi]
AB  - BACKGROUND: Although user involvement in research is an area of high priority
      there is a lack of knowledge about how users of the mental health system perceive
      participation in studies carried out by other users. AIM: The aim of the study
      was to describe how users experience participation in research interviews
      performed by other users. METHOD: A varied sample of 17 mental health users with 
      experience of being interviewed in a research project by another user was
      thematically interviewed in this qualitative study. Data was subject to content
      analysis. RESULTS: Being interviewed by another user was a special experience
      including both negative and positive aspects, and took place in an atmosphere of 
      comradeship. However, being interviewed by another user could generate feelings
      of insecurity. This finding indicates requirements from the informants how to
      perform user-involved research in the future. CONCLUSIONS: In planning for
      user-involved research education, it is necessary to consider training and issues
      related to secure ethical principals concerning the informants.
FAU - Bengtsson-Tops, A
AU  - Bengtsson-Tops A
AD  - Vaxjo University, Sweden. anita.bengtsson_tops@vxu.se
      <anita.bengtsson_tops@vxu.se>
FAU - Svensson, B
AU  - Svensson B
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Ment Health
JT  - Journal of mental health (Abingdon, England)
JID - 9212352
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomedical Research/*methods
MH  - Cooperative Behavior
MH  - Emotions
MH  - Ethics, Research
MH  - Female
MH  - Humans
MH  - Interviews as Topic/*methods
MH  - Male
MH  - Mental Disorders/*psychology
MH  - Middle Aged
MH  - Patient Satisfaction
MH  - Research Subjects/*psychology
EDAT- 2010/05/06 06:00
MHDA- 2010/07/29 06:00
CRDT- 2010/05/06 06:00
PHST- 2010/05/06 06:00 [entrez]
PHST- 2010/05/06 06:00 [pubmed]
PHST- 2010/07/29 06:00 [medline]
AID - 10.3109/09638230903531084 [doi]
PST - ppublish
SO  - J Ment Health. 2010 Jun;19(3):237-42. doi: 10.3109/09638230903531084.


PMID- 20440663
OWN - NLM
STAT- MEDLINE
DCOM- 20100908
LR  - 20100604
IS  - 1496-8975 (Electronic)
IS  - 0832-610X (Linking)
VI  - 57
IP  - 7
DP  - 2010 Jul
TI  - Incomplete adherence to the ASA difficult airway algorithm is unchanged after a
      high-fidelity simulation session.
PG  - 644-9
LID - 10.1007/s12630-010-9322-4 [doi]
AB  - PURPOSE: Although guidelines for difficult airway management have been published,
      the extent to which consultant anesthesiologists follow these guidelines has not 
      been determined. The purpose of this study is to observe how consultant
      anesthesiologists manage a "cannot intubate, cannot ventilate" (CICV) scenario in
      a high-fidelity simulator and to evaluate whether a simulation teaching session
      improves their adherence to the American Society of Anesthesiologists (ASA)
      difficult airway algorithm. METHODS: With Ethics Board approval and informed
      consent, all staff anesthesiologists in a single tertiary care institution were
      invited to enrol in this study where they managed a simulated unanticipated CICV 
      scenario in a high-fidelity simulator. The scenario involved a patient with a
      difficult airway whose trachea could not be intubated and where it was impossible
      to ventilate the patient's lungs. Airway management options, including laryngeal 
      mask airway, a fibreoptic bronchoscope, and a Glidescope were available for use
      but scripted to fail. A percutaneous cricothyroidotomy was required to
      re-establish adequate ventilation. Following the scenario, there was a
      personalized one-hour video-assisted expert debriefing focusing on the ASA
      difficult airway guidelines and "hands-on" cricothyroidotomy teaching. The second
      scenario followed immediately with an identical CICV scenario. The content to
      either scenario was not revealed beforehand. Outcome measures included: 1) major 
      deviations from the ASA difficult airway guidelines; 2) time to start
      cricothyroidotomy; and 3) time to achieve ventilation. RESULTS: Thirty-eight
      anesthesiologists agreed to participate. The number of major deviations from the 
      ASA algorithm was similar in the first and second sessions. These deviations
      included: multiple laryngoscopies (0 vs 2 pre-post; P = 0.49), use of fibreoptic 
      bronchoscope (8 vs 7 pre-post; P = 1.0), bypass of laryngeal mask airway attempt 
      (7 vs 13 pre-post; P = 0.19), and failure to call for anesthetic help (12 vs 8
      pre-post; P = 0.43). However, more participants failed to call for surgical help 
      in the second session (7 vs 16; P = 0.04). The times to start cricothyroidotomy
      and the times to achieve ventilation were significantly shorter in the second
      session (205.5 +/- 61.3 sec vs 179.7 +/- 65.1 sec; P = 0.01 and 356.9 +/- 117.2
      sec vs 269.4 +/- 77.43 sec; P = 0.0002, respectively). CONCLUSION: No substantial
      changes in airway management in a CICV scenario were observed after an intense
      one-hour personalized video-assisted airway-focused simulation debriefing session
      with an expert. It appears that multiple factors other than airway algorithms
      come into play in emergency airway decision-making processes, including one's
      personal clinical experience with the many available airway devices.
FAU - Borges, Bruno C R
AU  - Borges BC
AD  - Department of Anesthesia, St. Michael's Hospital, University of Toronto, ON,
      Canada.
FAU - Boet, Sylvain
AU  - Boet S
FAU - Siu, Lyndon W
AU  - Siu LW
FAU - Bruppacher, Heinz R
AU  - Bruppacher HR
FAU - Naik, Viren N
AU  - Naik VN
FAU - Riem, Nicole
AU  - Riem N
FAU - Joo, Hwan S
AU  - Joo HS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100504
PL  - United States
TA  - Can J Anaesth
JT  - Canadian journal of anaesthesia = Journal canadien d'anesthesie
JID - 8701709
SB  - IM
CIN - Can J Anaesth. 2010 Jul;57(7):627-35. PMID: 20431979
MH  - Adult
MH  - *Algorithms
MH  - Anesthesiology/education
MH  - *Clinical Competence
MH  - Education, Medical, Continuing
MH  - Female
MH  - Fracture Fixation, Internal
MH  - Guideline Adherence/*statistics & numerical data
MH  - Humans
MH  - Intubation, Intratracheal/*methods/*statistics & numerical data
MH  - Male
MH  - Mandibular Fractures/complications/surgery
MH  - Middle Aged
MH  - *Patient Simulation
MH  - Sample Size
EDAT- 2010/05/05 06:00
MHDA- 2010/09/09 06:00
CRDT- 2010/05/05 06:00
PHST- 2010/01/30 00:00 [received]
PHST- 2010/04/15 00:00 [accepted]
PHST- 2010/05/05 06:00 [entrez]
PHST- 2010/05/05 06:00 [pubmed]
PHST- 2010/09/09 06:00 [medline]
AID - 10.1007/s12630-010-9322-4 [doi]
PST - ppublish
SO  - Can J Anaesth. 2010 Jul;57(7):644-9. doi: 10.1007/s12630-010-9322-4. Epub 2010
      May 4.


PMID- 20440104
OWN - NLM
STAT- MEDLINE
DCOM- 20100813
LR  - 20191111
IS  - 1594-0667 (Print)
IS  - 1594-0667 (Linking)
VI  - 22
IP  - 2
DP  - 2010 Apr
TI  - Upper age limits in studies submitted to a research ethics committee.
PG  - 175-8
AB  - BACKGROUND AND AIMS: Discrimination in research of new drugs for older people is 
      frequent. We examined research protocols submitted to a research ethics
      committee, to ascertain whether they stipulated unjustified upper age limits, and
      whether these age limits are changing in time. METHODS: Systematic review of
      protocols of studies submitted to the Research Ethics Committee of a public
      university hospital, in four different years, looking for unjustified upper age
      limits. Studies that dealt with topics or conditions that automatically excluded 
      older people were not examined. RESULTS: In the first three cohorts of protocols 
      of intervention studies (1994, 1999, 2004), 36% to 40% stipulated an upper age
      limit. In 2007, only 19% of the protocols showed an unjustified limit.
      Non-intervention trials rarely had upper age limits. Age limits were arbitrarily 
      chosen (65, 70, 75 or 80 years were chosen as cut-off points in most cases). Five
      to 6% of the protocols specifically concerned older persons, with no change in
      time. CONCLUSIONS: Unjustified age limits are frequent in the protocols of
      intervention studies, although the numbers have been falling recently. Ethics
      research committees are in a strong position to influence research practice and
      to reduce unethical age discrimination.
FAU - Cruz-Jentoft, Alfonso J
AU  - Cruz-Jentoft AJ
AD  - Servicio de Geriatria, Hospital Universitario Ramon y Cajal, Madrid, Spain.
      acruz.hrc@salud.madrid.org
FAU - Gutierrez, Begona
AU  - Gutierrez B
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Aging Clin Exp Res
JT  - Aging clinical and experimental research
JID - 101132995
SB  - IM
MH  - *Age Factors
MH  - Aged
MH  - *Clinical Trials as Topic
MH  - Cohort Studies
MH  - *Ethics Committees, Research
MH  - *Ethics, Medical
MH  - Humans
MH  - Patient Selection
MH  - *Prejudice
MH  - Randomized Controlled Trials as Topic
EDAT- 2010/05/05 06:00
MHDA- 2010/08/14 06:00
CRDT- 2010/05/05 06:00
PHST- 2010/05/05 06:00 [entrez]
PHST- 2010/05/05 06:00 [pubmed]
PHST- 2010/08/14 06:00 [medline]
AID - 7019 [pii]
AID - 10.1007/BF03324793 [doi]
PST - ppublish
SO  - Aging Clin Exp Res. 2010 Apr;22(2):175-8. doi: 10.1007/BF03324793.


PMID- 20439699
OWN - NLM
STAT- MEDLINE
DCOM- 20100521
LR  - 20160512
IS  - 1535-1386 (Electronic)
IS  - 0021-9355 (Linking)
VI  - 92
IP  - 5
DP  - 2010 May
TI  - Examining the ethical implications of an orthopaedic joint registry.
PG  - 1330-3
LID - 10.2106/JBJS.I.01410 [doi]
AB  - R.P., a fifty-seven-year-old man, underwent a total hip replacement with a newly 
      designed, cementless hip system. Within the first several months after surgery,
      he had persistent thigh pain. Radiographs made at one year indicated progressive 
      radiolucent lines surrounding the femoral component. He required revision surgery
      for aseptic loosening of the femoral component. Several months following the
      revision, a single journal article indicating a similar problem at another
      institution with the same device was published. A year later, two additional
      articles appeared in the literature. One year later, the femoral device
      originally implanted in R.P. was removed from the market.
FAU - Capozzi, James D
AU  - Capozzi JD
AD  - Department of Orthopaedic Surgery, Winthrop University Hospital, Mineola, NY
      11501, USA. jcapozzi@winthrop.org
FAU - Rhodes, Rosamond
AU  - Rhodes R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Bone Joint Surg Am
JT  - The Journal of bone and joint surgery. American volume
JID - 0014030
SB  - IM
MH  - Arthroplasty, Replacement/*adverse effects
MH  - Ethics, Clinical
MH  - Humans
MH  - Orthopedics/*ethics
MH  - Registries/*ethics
EDAT- 2010/05/05 06:00
MHDA- 2010/05/22 06:00
CRDT- 2010/05/05 06:00
PHST- 2010/05/05 06:00 [entrez]
PHST- 2010/05/05 06:00 [pubmed]
PHST- 2010/05/22 06:00 [medline]
AID - 92/5/1330 [pii]
AID - 10.2106/JBJS.I.01410 [doi]
PST - ppublish
SO  - J Bone Joint Surg Am. 2010 May;92(5):1330-3. doi: 10.2106/JBJS.I.01410.


PMID- 20439358
OWN - NLM
STAT- MEDLINE
DCOM- 20100826
LR  - 20220309
IS  - 1744-5019 (Electronic)
IS  - 0360-5310 (Linking)
VI  - 35
IP  - 3
DP  - 2010 Jun
TI  - Constructing the death elephant: a synthetic paradigm shift for the definition,
      criteria, and tests for death.
PG  - 256-98
LID - 10.1093/jmp/jhq022 [doi]
AB  - In debates about criteria for human death, several camps have emerged, the main
      two focusing on either loss of the "organism as a whole" (the mainstream view) or
      loss of consciousness or "personhood." Controversies also rage over the proper
      definition of "irreversible" in criteria for death. The situation is reminiscent 
      of the proverbial blind men palpating an elephant; each describes the creature
      according to the part he can touch. Similarly, each camp grasps some aspect of
      the complex reality of death. The personhood camp, in contrast to the mainstream 
      "organism" camp, recognizes that a human organism can still be a biological
      living whole even without brain function. The mainstream camp, in contrast to the
      personhood camp, recognizes that a person can be permanently, even irreversibly
      unconscious, and still be a living person so long as his/her body is alive. The
      author proposes that hylomorphic dualism incorporates both these key insights.
      But to complete the picture of the entire "death elephant," a fundamental
      paradigm shift is needed to make sense of other seemingly conflicting insights.
      The author proposes a "semantic bisection" of the concept of death, analogous to 
      the traditional distinction at the beginning of life between "conception" and
      "birth." To avoid the semantic baggage associated with the term "death," the two 
      new death-related concepts are referred to as "passing away" (or "deceased") and 
      "deanimation," corresponding, respectively, to sociolegal ceasing-to-be (mirror
      image of birth) and ontological/theological ceasing-to-be of the bodily organism 
      (mirror image of conception). Regarding criteria, the distinguishing feature is
      whether the cessation of function is permanent (passing away) or irreversible
      (deanimation). If the "dead donor rule" were renamed the "deceased donor rule"
      (both acronyms felicitously being "DDR"), the ethics of organ transplantation
      from non-heart-beating donors could, in principle, be validly governed by the
      DDR, even though the donors are not yet ontologically "deanimated." Thus, the
      paradigm shift satisfies both those who insist on maintaining the DDR and those
      who claim that it has all along been receiving only lip service and should be
      explicitly loosened to include those who are "as good as dead." Even so, a number
      of practical caveats remain to be worked out for non-heart-beating protocols.
FAU - Shewmon, D Alan
AU  - Shewmon DA
AD  - David Geffen School of Medicine at UCLA, Los Angeles, CA 91342-1495, USA.
      ashewmon@mednet.ucla.edu
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100503
PL  - United States
TA  - J Med Philos
JT  - The Journal of medicine and philosophy
JID - 7610512
SB  - IM
MH  - Animals
MH  - Attitude to Death
MH  - *Bioethical Issues
MH  - Brain/physiology
MH  - Brain Death/*diagnosis
MH  - *Death
MH  - Decapitation
MH  - Humans
MH  - Personhood
MH  - *Tissue Donors
MH  - Unconsciousness
RF  - 123
EDAT- 2010/05/05 06:00
MHDA- 2010/08/27 06:00
CRDT- 2010/05/05 06:00
PHST- 2010/05/05 06:00 [entrez]
PHST- 2010/05/05 06:00 [pubmed]
PHST- 2010/08/27 06:00 [medline]
AID - jhq022 [pii]
AID - 10.1093/jmp/jhq022 [doi]
PST - ppublish
SO  - J Med Philos. 2010 Jun;35(3):256-98. doi: 10.1093/jmp/jhq022. Epub 2010 May 3.


PMID- 20439356
OWN - NLM
STAT- MEDLINE
DCOM- 20100826
LR  - 20100524
IS  - 1744-5019 (Electronic)
IS  - 0360-5310 (Linking)
VI  - 35
IP  - 3
DP  - 2010 Jun
TI  - The ethics of creating and responding to doubts about death criteria.
PG  - 365-80
LID - 10.1093/jmp/jhq021 [doi]
AB  - Expressing doubts about death criteria can serve healthy purposes, but can also
      cause a number of harms, including decreased organ donation rates and distress
      for donor families and health care staff. This paper explores the various causes 
      of doubts about death criteria-including religious beliefs, misinformation,
      mistrust, and intellectual questions-and recommends responses to each of these.
      Some recommended responses are relatively simple and noncontroversial, such as
      providing accurate information. However, other responses would require
      significant changes to the way we currently do business. Policymakers should
      establish minimum national standards for determining death to foster a
      trustworthy system; academics and publishers have a duty to publish only
      materials that substantially engage and advance the debate to minimize the harm
      caused by divided expert opinion; and opposition to the dead donor rule should be
      conceptually separated from doubts about death criteria.
FAU - Dubois, James M
AU  - Dubois JM
AD  - Saint Louis University, 221 N Grand Blvd, St. Louis, MO 63103, USA.
      duboisjm@slu.edu
LA  - eng
PT  - Journal Article
DEP - 20100503
PL  - United States
TA  - J Med Philos
JT  - The Journal of medicine and philosophy
JID - 7610512
SB  - IM
MH  - Attitude of Health Personnel
MH  - *Bioethical Issues
MH  - *Brain Death
MH  - *Death
MH  - Humans
MH  - *Tissue Donors
MH  - *Tissue and Organ Harvesting/ethics
MH  - Tissue and Organ Procurement
MH  - Uncertainty
EDAT- 2010/05/05 06:00
MHDA- 2010/08/27 06:00
CRDT- 2010/05/05 06:00
PHST- 2010/05/05 06:00 [entrez]
PHST- 2010/05/05 06:00 [pubmed]
PHST- 2010/08/27 06:00 [medline]
AID - jhq021 [pii]
AID - 10.1093/jmp/jhq021 [doi]
PST - ppublish
SO  - J Med Philos. 2010 Jun;35(3):365-80. doi: 10.1093/jmp/jhq021. Epub 2010 May 3.


PMID- 20439355
OWN - NLM
STAT- MEDLINE
DCOM- 20100826
LR  - 20211020
IS  - 1744-5019 (Electronic)
IS  - 0360-5310 (Linking)
VI  - 35
IP  - 3
DP  - 2010 Jun
TI  - The dead donor rule: can it withstand critical scrutiny?
PG  - 299-312
LID - 10.1093/jmp/jhq019 [doi]
AB  - Transplantation of vital organs has been premised ethically and legally on "the
      dead donor rule" (DDR)-the requirement that donors are determined to be dead
      before these organs are procured. Nevertheless, scholars have argued cogently
      that donors of vital organs, including those diagnosed as "brain dead" and those 
      declared dead according to cardiopulmonary criteria, are not in fact dead at the 
      time that vital organs are being procured. In this article, we challenge the
      normative rationale for the DDR by rejecting the underlying premise that it is
      necessarily wrong for physicians to cause the death of patients and the claim
      that abandoning this rule would exploit vulnerable patients. We contend that it
      is ethical to procure vital organs from living patients sustained on life support
      prior to treatment withdrawal, provided that there is valid consent for both
      withdrawing treatment and organ donation. However, the conservatism of medical
      ethics and practical concerns make it doubtful that the DDR will be abandoned in 
      the near future. This leaves the current practice of organ transplantation based 
      on the "moral fiction" that donors are dead when vital organs are procured.
FAU - Miller, Franklin G
AU  - Miller FG
AD  - National Institutes of Health, Bethesda, MD 20892-1156, USA. fmiller@nih.gov
FAU - Truog, Robert D
AU  - Truog RD
FAU - Brock, Dan W
AU  - Brock DW
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Review
DEP - 20100503
PL  - United States
TA  - J Med Philos
JT  - The Journal of medicine and philosophy
JID - 7610512
SB  - IM
MH  - Attitude to Death
MH  - *Bioethical Issues
MH  - Brain Death/*diagnosis
MH  - *Death
MH  - Ethics, Medical
MH  - Humans
MH  - *Life Support Care
MH  - Morals
MH  - *Tissue Donors
MH  - Withholding Treatment
RF  - 25
PMC - PMC3916748
EDAT- 2010/05/05 06:00
MHDA- 2010/08/27 06:00
CRDT- 2010/05/05 06:00
PHST- 2010/05/05 06:00 [entrez]
PHST- 2010/05/05 06:00 [pubmed]
PHST- 2010/08/27 06:00 [medline]
AID - jhq019 [pii]
AID - 10.1093/jmp/jhq019 [doi]
PST - ppublish
SO  - J Med Philos. 2010 Jun;35(3):299-312. doi: 10.1093/jmp/jhq019. Epub 2010 May 3.


PMID- 20439354
OWN - NLM
STAT- MEDLINE
DCOM- 20100826
LR  - 20100524
IS  - 1744-5019 (Electronic)
IS  - 0360-5310 (Linking)
VI  - 35
IP  - 3
DP  - 2010 Jun
TI  - Transplanting hearts after death measured by cardiac criteria: the challenge to
      the dead donor rule.
PG  - 313-29
LID - 10.1093/jmp/jhq020 [doi]
AB  - The current definition of death used for donation after cardiac death relies on a
      determination of the irreversible cessation of the cardiac function. Although
      this criterion can be compatible with transplantation of most organs, it is not
      compatible with heart transplantation since heart transplants by definition
      involve the resuscitation of the supposedly "irreversibly" stopped heart.
      Subsequently, the definition of "irreversible" has been altered so as to permit
      heart transplantation in some circumstances, but this is unsatisfactory. There
      are three available strategies for solving this "irreversibility problem":
      altering the definition of death so as to rely on circulatory irreversibility,
      rather than cardiac; defining death strictly on the basis of brain death (either 
      whole-brain or more pragmatically some higher brain criteria); or redefining
      death in traditional terms and simultaneously legalizing some limited instances
      of medical killing to procure viable hearts. The first two strategies are the
      most ethically justifiable and practical.
FAU - Veatch, Robert M
AU  - Veatch RM
AD  - Georgetown University, Washington, DC 20057, USA. veatchr@georgetown.edu
LA  - eng
PT  - Journal Article
DEP - 20100503
PL  - United States
TA  - J Med Philos
JT  - The Journal of medicine and philosophy
JID - 7610512
SB  - IM
MH  - *Bioethical Issues
MH  - Brain Death/*diagnosis
MH  - *Death
MH  - *Heart Transplantation
MH  - Humans
MH  - Life Support Care
MH  - *Tissue Donors
MH  - *Tissue and Organ Harvesting
MH  - Withholding Treatment
EDAT- 2010/05/05 06:00
MHDA- 2010/08/27 06:00
CRDT- 2010/05/05 06:00
PHST- 2010/05/05 06:00 [entrez]
PHST- 2010/05/05 06:00 [pubmed]
PHST- 2010/08/27 06:00 [medline]
AID - jhq020 [pii]
AID - 10.1093/jmp/jhq020 [doi]
PST - ppublish
SO  - J Med Philos. 2010 Jun;35(3):313-29. doi: 10.1093/jmp/jhq020. Epub 2010 May 3.


PMID- 20439337
OWN - NLM
STAT- MEDLINE
DCOM- 20100818
LR  - 20100507
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 5
DP  - 2010 May
TI  - Enhancement's place in medicine.
PG  - 293-6
LID - 10.1136/jme.2009.032383 [doi]
AB  - Many enhancement technologies are distributed by healthcare professionals-by
      physicians-who are held to the Hippocratic Oath and the goals of medicine. While 
      the ethics of enhancement has been widely discussed with regard to the social
      justice, humanism, morals and normative values of these interventions, their
      place in medicine has not attracted a great deal of attention. This paper
      investigates the potential for enhancement technologies to fulfil the goals of
      medicine, arguing that they play a role in promoting the health of individuals,
      and thus, an unavoidable place in medicine. It also warns of potential dangers,
      suggesting a set of guidelines to initiate conversations regarding the role and
      responsibilities of physicians practising in an era of enhancement.
FAU - Scripko, Patricia D
AU  - Scripko PD
AD  - Cleveland Clinic Lerner College of Medicine of Case Western Reserve University,
      9500 Euclid Avenue, NA21, Cleveland, OH 44195, USA. Scripkp@ccf.org
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100503
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Ethics, Medical
MH  - Goals
MH  - Health Promotion/*ethics/history
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
EDAT- 2010/05/05 06:00
MHDA- 2010/08/19 06:00
CRDT- 2010/05/05 06:00
PHST- 2010/05/05 06:00 [entrez]
PHST- 2010/05/05 06:00 [pubmed]
PHST- 2010/08/19 06:00 [medline]
AID - jme.2009.032383 [pii]
AID - 10.1136/jme.2009.032383 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 May;36(5):293-6. doi: 10.1136/jme.2009.032383. Epub 2010 May
      3.


PMID- 20439336
OWN - NLM
STAT- MEDLINE
DCOM- 20100818
LR  - 20100507
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 5
DP  - 2010 May
TI  - The ethical physician encounters international medical travel.
PG  - 297-301
LID - 10.1136/jme.2009.032789 [doi]
AB  - International medical travel occurs when patients cross national borders to
      purchase medical goods and services. On occasion, physicians in home countries
      will be the last point of domestic contact for patients seeking healthcare
      information before they travel abroad for care. When this is the case, physicians
      have a unique opportunity to inform patients about their options and help guide
      them towards ethical practices. This opportunity brings to the fore an important 
      question: What role should physicians in more-developed home countries play in
      promoting or constraining international medical travel towards less-developed
      destination countries? In our view, critical attention to the decision spaces of 
      patients-defined by the personal circumstances, socio-cultural cues, and legal
      constraints that inform decision-making-is a useful starting point for evaluating
      the proper response of physicians to various forms of international medical
      travel.
FAU - Crozier, G K D
AU  - Crozier GK
AD  - Department of Philosophy, Loyola University Chicago, 1032 West Sheridan Road,
      Chicago, IL 60660, USA. g.crozier@gmail.com
FAU - Baylis, Francoise
AU  - Baylis F
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100503
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Decision Making
MH  - Health Promotion/ethics
MH  - Humans
MH  - Medical Tourism/*ethics
MH  - Patient Education as Topic/*ethics
MH  - *Physician's Role
EDAT- 2010/05/05 06:00
MHDA- 2010/08/19 06:00
CRDT- 2010/05/05 06:00
PHST- 2010/05/05 06:00 [entrez]
PHST- 2010/05/05 06:00 [pubmed]
PHST- 2010/08/19 06:00 [medline]
AID - jme.2009.032789 [pii]
AID - 10.1136/jme.2009.032789 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 May;36(5):297-301. doi: 10.1136/jme.2009.032789. Epub 2010 May
      3.


PMID- 20439334
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20100610
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 6
DP  - 2010 Jun
TI  - Clinician gate-keeping in clinical research is not ethically defensible: an
      analysis.
PG  - 363-6
LID - 10.1136/jme.2009.031716 [doi]
AB  - Clinician gate-keeping is the process whereby healthcare providers prevent access
      to eligible patients for research recruitment. This paper contends that clinician
      gate-keeping violates three principles that underpin international ethical
      guidelines: respect for persons or autonomy; beneficence or a favourable balance 
      of risks and potential benefits; and justice or a fair distribution of the
      benefits and burdens of research. In order to stimulate further research and
      debate, three possible strategies are also presented to eliminate gate-keeping:
      partnership with professional researchers; collaborative research design and
      clinician education.
FAU - Sharkey, Kerith
AU  - Sharkey K
AD  - Department of Nursing and Supportive Care Research, Peter MacCallum Cancer
      Centre, East Melbourne, Australia.
FAU - Savulescu, Julian
AU  - Savulescu J
FAU - Aranda, Sanchia
AU  - Aranda S
FAU - Schofield, Penelope
AU  - Schofield P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100503
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Biomedical Research/*ethics/*methods
MH  - Cooperative Behavior
MH  - *Ethics, Medical
MH  - Humans
MH  - Interprofessional Relations
MH  - Patient Rights
MH  - Patient Selection/*ethics
MH  - Personal Autonomy
EDAT- 2010/05/05 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/05/05 06:00
PHST- 2010/05/05 06:00 [entrez]
PHST- 2010/05/05 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - jme.2009.031716 [pii]
AID - 10.1136/jme.2009.031716 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Jun;36(6):363-6. doi: 10.1136/jme.2009.031716. Epub 2010 May
      3.


PMID- 20439332
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20181201
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 6
DP  - 2010 Jun
TI  - Eluana Englaro, chronicle of a death foretold: ethical considerations on the
      recent right-to-die case in Italy.
PG  - 333-5
LID - 10.1136/jme.2009.034835 [doi]
AB  - In 1992, Eluana Englaro was involved in a car accident in Italy that eventually
      left her in a permanent vegetative state requiring artificial nutrition and
      hydration. This paper, after briefly reviewing Eluana's case, gives a chronicle
      of Eluana last months until her death on 9 February 2009, and discusses the
      right-to-die controversy in Italy. For many years, Mr Englaro, Eluana's father,
      would litigate to enforce what he considered to be his daughter's wish to
      discontinue life-prolonging treatment. In July 2008, the Court of Appeal of Milan
      has given its authorization for artificial life support to be withdrawn. This
      ruling sparked a crusade, led by the government and the Vatican, against the
      court and Eluana's father, which included insinuations that the latter was
      murdering his daughter. Public opinion has overwhelmingly been sympathetic to the
      father's difficult decision, in stark contrast to the reactionary stance taken by
      the government. With the notable advances of medicine, doctors are increasingly
      faced with ethical issues. The vegetative state is just one of the many clinical 
      conditions that obligate health professionals to reflect on ethical matters. The 
      withdrawal of life-supporting care, and of artificial nutrition and hydration in 
      particular in permanent vegetative state patients remains a measure which
      violates a tradition and a consolidated practice. It was thus inevitable that it 
      would create great controversy. We should work towards making a decision process 
      that ensures that continuation or suspension of artificial nutrition and
      hydration follows an explicit procedure, promoting the sharing and respect of the
      diverse moral responsibility of family members, nursing and medical staff.
FAU - Luchetti, Marco
AU  - Luchetti M
AD  - Department of Anaesthesia & Intensive Care, A Manzoni General Hospital, Via
      dell'Eremo 9/11, Lecco, Italy. m.luchetti@fastwebnet.it
LA  - eng
PT  - Journal Article
PT  - Legal Case
DEP - 20100503
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Ethics, Medical
MH  - *Euthanasia, Passive/ethics/legislation & jurisprudence
MH  - Female
MH  - Humans
MH  - Italy
MH  - Patient Advocacy
MH  - Persistent Vegetative State/*therapy
MH  - *Right to Die/ethics/legislation & jurisprudence
EDAT- 2010/05/05 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/05/05 06:00
PHST- 2010/05/05 06:00 [entrez]
PHST- 2010/05/05 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - jme.2009.034835 [pii]
AID - 10.1136/jme.2009.034835 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Jun;36(6):333-5. doi: 10.1136/jme.2009.034835. Epub 2010 May
      3.


PMID- 20439330
OWN - NLM
STAT- MEDLINE
DCOM- 20100818
LR  - 20151119
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 5
DP  - 2010 May
TI  - When enough is enough; terminating life-sustaining treatment at the patient's
      request: a survey of attitudes among Swedish physicians and the general public.
PG  - 284-9
LID - 10.1136/jme.2009.034967 [doi]
AB  - OBJECTIVES: To explore attitudes and reasoning among Swedish physicians and the
      general public regarding the withdrawal of life-sustaining treatment at a
      competent patient's request. DESIGN: A vignette-based postal questionnaire
      including 1202 randomly selected individuals in the county of Stockholm and 1200 
      randomly selected Swedish physicians with various specialities. The vignettes
      described patients requesting withdrawal of their life-sustaining treatment: (1) 
      a 77-year-old woman on dialysis; (2) a 36-year-old man on dialysis; (3) a
      34-year-old ventilator-dependent tetraplegic man. Responders were asked to
      classify the act of terminating treatment and to prioritise arguments
      for/against. RESULTS: A majority in both groups prioritised arguments in favour
      of terminating treatment and classified the act as defensible in all vignettes.
      However, among the general public, 16% classified the act as euthanasia in all
      vignettes; among physicians this view was most expressed regarding ventilator
      treatment (26%). Some who classified the act as euthanasia prioritised arguments 
      in favour of terminating treatment: among physicians 18% in vignette 1, 19% in
      vignette 2 and 34% in vignette 3; among the general public 35% in vignette 1, 20%
      in vignette 2 and 48% in vignette 3. CONCLUSION: There is a widespread consensus 
      regarding competent patients' right to abstain from life-sustaining treatment. An
      association between the hastening of death, caused by the withdrawal of
      life-sustaining treatment and the concept of euthanasia is proposed. The results 
      also suggest that classifying the withdrawal of life-sustaining treatment as
      'euthanasia' does not necessarily mean that the act is interpreted as ethically
      unacceptable.
FAU - Lindblad, Anna
AU  - Lindblad A
AD  - LIME, Karolinska Institutet, Stockholm 171 77, Sweden. anna.lindblad@ki.se
FAU - Juth, Niklas
AU  - Juth N
FAU - Furst, Carl Johan
AU  - Furst CJ
FAU - Lynoe, Niels
AU  - Lynoe N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100503
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - *Attitude of Health Personnel
MH  - *Attitude to Death
MH  - Decision Making/ethics
MH  - Euthanasia, Passive/*ethics
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Public Opinion
MH  - Sex Factors
MH  - Surveys and Questionnaires
MH  - Sweden
MH  - Treatment Refusal/ethics
MH  - Young Adult
EDAT- 2010/05/05 06:00
MHDA- 2010/08/19 06:00
CRDT- 2010/05/05 06:00
PHST- 2010/05/05 06:00 [entrez]
PHST- 2010/05/05 06:00 [pubmed]
PHST- 2010/08/19 06:00 [medline]
AID - jme.2009.034967 [pii]
AID - 10.1136/jme.2009.034967 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 May;36(5):284-9. doi: 10.1136/jme.2009.034967. Epub 2010 May
      3.


PMID- 20439329
OWN - NLM
STAT- MEDLINE
DCOM- 20100818
LR  - 20151119
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 5
DP  - 2010 May
TI  - Scientific dishonesty--questionnaire to doctoral students in Sweden.
PG  - 315-8
LID - 10.1136/jme.2009.033654 [doi]
AB  - 'Scientific dishonesty' implies the fabrication, falsification or plagiarism in
      proposing, performing or reviewing research or in reporting research results. A
      questionnaire was given to postgraduate students at the medical faculties in
      Sweden who attended a course in research ethics during the academic year
      2008/2009 and 58% answered (range 29%-100%). Less than one-third of the
      respondents wrote that they had heard about scientific dishonesty in the previous
      12 months. Pressure, concerning in what order the author should be mentioned, was
      reported by about 1 in 10 students. We suggest that all departments conducting
      research should have a written policy about acceptable research behaviour and
      that all doctoral students should be informed of the content of this policy.
      Participants in the research groups concerned should also be required to analyse 
      published articles about scientific dishonesty and critically discuss what could 
      be done about unethical conduct.
FAU - Nilstun, Tore
AU  - Nilstun T
AD  - Department of Medical Ethics, Lund University, Sangarevagen 4c, Lund S-224 71,
      Sweden. tore.nilstun@med.lu.se
FAU - Lofmark, Rurik
AU  - Lofmark R
FAU - Lundqvist, Anita
AU  - Lundqvist A
LA  - eng
PT  - Journal Article
DEP - 20100503
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Attitude of Health Personnel
MH  - Biomedical Research/ethics
MH  - *Deception
MH  - Ethics, Professional
MH  - *Ethics, Research
MH  - Humans
MH  - Scientific Misconduct/*ethics
MH  - Students, Medical/*psychology
MH  - Surveys and Questionnaires
MH  - Sweden
EDAT- 2010/05/05 06:00
MHDA- 2010/08/19 06:00
CRDT- 2010/05/05 06:00
PHST- 2010/05/05 06:00 [entrez]
PHST- 2010/05/05 06:00 [pubmed]
PHST- 2010/08/19 06:00 [medline]
AID - jme.2009.033654 [pii]
AID - 10.1136/jme.2009.033654 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 May;36(5):315-8. doi: 10.1136/jme.2009.033654. Epub 2010 May
      3.


PMID- 20439328
OWN - NLM
STAT- MEDLINE
DCOM- 20100818
LR  - 20100507
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 5
DP  - 2010 May
TI  - Ethical and existential challenges associated with a cancer diagnosis.
PG  - 279-83
LID - 10.1136/jme.2009.034942 [doi]
AB  - BACKGROUND: At the point of cancer diagnosis, practitioners may wrestle with
      ethical dilemmas associated with medico-legal implications of diagnosis,
      treatment options and disclosure to family members. The patient's perspective can
      take a different route, focusing on ethical and existential questions about the
      value and purpose of life, culminating in the question: how do I lead my life
      after diagnosis? OBJECTIVE: To explore the ethical and existential challenges
      associated with a cancer diagnosis from the perspective of cancer survivors.
      DESIGN: Qualitative design using specifically phenomenological methods to enable 
      focus on subjective experience. Two in-depth interviews were conducted over a
      6-month period. SETTING: Bendigo, Victoria, Australia. PARTICIPANTS: 15
      participants (n=11 women and n=4 men) volunteered to be interviewed. Age ranged
      from 32 to 85 years of age; length of survival 0.5-25 years; with a range of
      cancer diagnoses. RESULTS: Findings demonstrated that participants experienced
      existential and ethical challenges associated with a cancer diagnosis and
      subsequent survivorhood. These challenges were present regardless of cancer stage
      or diagnostic type and pervaded throughout length of survival. The existential
      challenges included the experience of anxiety and uncertainty about recurrence
      and metastatic disease. In particular, participants reported iatrogenic
      uncertainty induced by tests and treatment with follow-up regimes underscoring
      the fragility of survivor status. Uncertainty served as a 'wake-up call' and
      precipitated ethical challenges. Such challenges involved making meaning of
      survivorhood and questioning of morals, values and relationships. At times these 
      questions were painful and difficult, creating unease about leading a 'good' and 
      purposeful life. Entering ethically rocky terrain was also considered identity
      enhancing, with reports that a cancer diagnosis could have benefits as well as
      challenges. CONCLUSION: This study identified a number of challenges associated
      with a cancer diagnosis; these have implications for the preparation of medical, 
      nursing and social work practitioners and should be considered during the design 
      of follow-up support for cancer patients and those in recovery.
FAU - Pascal, Jan
AU  - Pascal J
AD  - School of Social Work and Social Policy, La Trobe University, PO Box 199, Bendigo
      3552, Victoria, Australia. j.pascal@latrobe.edu.au
FAU - Endacott, Ruth
AU  - Endacott R
LA  - eng
PT  - Journal Article
DEP - 20100503
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Adaptation, Psychological
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Ethics, Medical
MH  - Ethics, Nursing
MH  - Existentialism/*psychology
MH  - Female
MH  - Humans
MH  - Life Change Events
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/*diagnosis/*psychology/therapy
MH  - Physician-Patient Relations
MH  - Qualitative Research
MH  - Survivors/*psychology
MH  - Victoria
EDAT- 2010/05/05 06:00
MHDA- 2010/08/19 06:00
CRDT- 2010/05/05 06:00
PHST- 2010/05/05 06:00 [entrez]
PHST- 2010/05/05 06:00 [pubmed]
PHST- 2010/08/19 06:00 [medline]
AID - jme.2009.034942 [pii]
AID - 10.1136/jme.2009.034942 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 May;36(5):279-83. doi: 10.1136/jme.2009.034942. Epub 2010 May 
      3.


PMID- 20439184
OWN - NLM
STAT- MEDLINE
DCOM- 20101007
LR  - 20181201
IS  - 1898-4002 (Electronic)
IS  - 1896-1126 (Linking)
VI  - 55
IP  - 1
DP  - 2010
TI  - Control of pancreatic secretion in humans.
PG  - 1-15
LID - 10.2478/v10039-010-0013-8 [doi]
AB  - Studies on the control of pancreatic secretion in humans of all ages have been a 
      difficult task over the years because of patients' availability and ethic
      committee rules. Nevertheless, studies were performed and the objectives of this 
      review are to summarize our knowledge on the development of secretory process in 
      newborns, on the different phases of the pancreatic responses to a meal, on the
      pancreatic responses to the different components of the diet, on the mechanisms
      involved in the control of the pancreatic responses, and finally on the receptors
      involved in these controls.
FAU - Morisset, J
AU  - Morisset J
AD  - Service de gastroenterologie, Departement de medecine, Faculte de medecine et des
      sciences de la sante, Universite de Sherbrooke, Sherbrooke, Quebec, Canada.
      jean.morisset@usherbrooke.ca
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Adv Med Sci
JT  - Advances in medical sciences
JID - 101276222
RN  - 0 (Gastrointestinal Hormones)
SB  - IM
MH  - Gastrointestinal Hormones/metabolism
MH  - Humans
MH  - Infant, Newborn
MH  - Pancreas/*metabolism
MH  - Postprandial Period
EDAT- 2010/05/05 06:00
MHDA- 2010/10/12 06:00
CRDT- 2010/05/05 06:00
PHST- 2010/05/05 06:00 [entrez]
PHST- 2010/05/05 06:00 [pubmed]
PHST- 2010/10/12 06:00 [medline]
AID - S1896-1126(14)60001-8 [pii]
AID - 10.2478/v10039-010-0013-8 [doi]
PST - ppublish
SO  - Adv Med Sci. 2010;55(1):1-15. doi: 10.2478/v10039-010-0013-8.


PMID- 20439060
OWN - NLM
STAT- MEDLINE
DCOM- 20100723
LR  - 20100504
IS  - 1876-7761 (Electronic)
IS  - 1876-7761 (Linking)
VI  - 8
IP  - 2
DP  - 2010 Apr
TI  - Alternative formulations, delivery methods, and administration options for
      psychotropic medications in elderly patients with behavioral and psychological
      symptoms of dementia.
PG  - 98-114
LID - 10.1016/j.amjopharm.2010.03.003 [doi]
AB  - OBJECTIVE: The purpose of this paper was to review alternative formulations,
      delivery methods, and administration options for psychotropic medications in
      elderly patients with behavioral and psychological symptoms of dementia (BPSD).
      METHODS: A MEDLINE search was conducted initially in December 2008 and was
      updated in September 2009, including the search terms pharmacologic treatment and
      dementia, behavioral and psychological symptoms of dementia, alternative
      psychotropic medication formulations, alternative dosing methods of medication,
      drug delivery options, antidepressants and dementia, anxiolytics and dementia,
      antipsychotics and dementia, mood stabilizers and dementia, cognitive enhancers
      and dementia, medications and enteral feeding tubes, and hiding medication.
      Studies were limited to English-language articles dated from 1950 to 2009.
      Additional relevant articles were obtained by reviewing the references in the
      initial articles. Drug Facts and Comparisons 4.0 Online, Lexi-Comp Online, and
      Lexi-Drugs Online were used to obtain additional information. Targeted patients
      were elderly individuals with BPSD who were considered difficult to treat because
      they were unable to swallow, were refusing medications, or were not able to eat
      or drink per physician order. RESULTS: In addition to the standard capsule or
      tablet given orally, a variety of formulations and delivery methods for
      psychotropic medications are available. Options include short- and long-acting
      intramuscular, intravenous, liquid, orally disintegrating, transdermal patch,
      sublingual, and rectal forms. Additionally, all formulations can be further
      altered in substance, delivery, or both. For example, tablets may be crushed and 
      capsules opened; this changes their formulation and allows the option of mixing
      with food or liquids to be taken by mouth or through a tube. Caution must be
      used, however; in certain cases, alteration of the original form or the intended 
      delivery method is contraindicated. In addition, many alternative administration 
      options are not formally approved for use in the manner in which they are
      commonly applied and are therefore used with little or no information on
      tolerability and effectiveness. Ethical and legal issues include patient consent 
      and off-label use. CONCLUSIONS: Overall, few studies have examined the use and
      efficacy of alternative psychotropic formulations and delivery methods in elderly
      patients with BPSD, and none have specifically addressed drug-alteration and
      alternative-administration issues. There is no evidence to compare alternative
      delivery forms (eg, tablet or capsule) of a given medication in terms of efficacy
      or tolerability. Still, alternative methods may be the only option for treatment 
      of some patients. Practitioners must be familiar with the range of formulations
      and delivery options available so that they can optimize their patients'
      medication regimens. More data are needed on the use of alternative formulations,
      delivery methods, and administration options and their limitations in this
      population.
CI  - Copyright 2010 Excerpta Medica Inc. All rights reserved.
FAU - Muramatsu, Russ S
AU  - Muramatsu RS
AD  - Department of Psychiatry, Tripler Army Medical Center, Honolulu, Hawaii 96859,
      USA. russ.muramatsu@amedd.army.mil
FAU - Litzinger, Mark H J
AU  - Litzinger MH
FAU - Fisher, Ed
AU  - Fisher E
FAU - Takeshita, Junji
AU  - Takeshita J
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
PL  - United States
TA  - Am J Geriatr Pharmacother
JT  - The American journal of geriatric pharmacotherapy
JID - 101190325
RN  - 0 (Psychotropic Drugs)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Dementia/*drug therapy/psychology
MH  - *Drug Delivery Systems
MH  - Humans
MH  - Off-Label Use
MH  - Psychotropic Drugs/*administration & dosage
RF  - 84
EDAT- 2010/05/05 06:00
MHDA- 2010/07/24 06:00
CRDT- 2010/05/05 06:00
PHST- 2009/10/23 00:00 [accepted]
PHST- 2010/05/05 06:00 [entrez]
PHST- 2010/05/05 06:00 [pubmed]
PHST- 2010/07/24 06:00 [medline]
AID - S1543-5946(10)00022-X [pii]
AID - 10.1016/j.amjopharm.2010.03.003 [doi]
PST - ppublish
SO  - Am J Geriatr Pharmacother. 2010 Apr;8(2):98-114. doi:
      10.1016/j.amjopharm.2010.03.003.


PMID- 20438946
OWN - NLM
STAT- MEDLINE
DCOM- 20100804
LR  - 20100504
IS  - 1531-5037 (Electronic)
IS  - 0022-3468 (Linking)
VI  - 45
IP  - 5
DP  - 2010 May
TI  - Investigating the use of preoperative nasogastric tubes and postoperative
      outcomes for infants with pyloric stenosis: a retrospective cohort study.
PG  - 1020-3
LID - 10.1016/j.jpedsurg.2010.02.026 [doi]
AB  - PURPOSE: Literature is lacking regarding the role of nasogastric tubes in
      patients with pyloric stenosis. There is also no consensus among surgeons. Some
      believe that pyloric stenosis is a form of gastric outlet obstruction, and the
      stomach should be drained until the obstruction is relieved. Others claim that
      infants can handle their secretions, and draining the stomach may further
      exacerbate the alkalosis. This chart review examines the use of preoperative
      nasogastric tubes in a single pediatric institution and its effect on vomiting
      rates and length of stay. METHODS: After research ethics board approval, a
      retrospective review was performed on 109 patients admitted between January 1,
      2007, and December 31, 2008, with pyloric stenosis who underwent pyloromyotomy.
      Data were collected on presence of a preoperative nasogastric tube, preoperative 
      electrolyte levels, ultrasound characteristics, episodes of postoperative
      vomiting, and length of stay. RESULTS: One hundred six patients were used in the 
      final analysis. A nasogastric tube was placed in 77 patients (73%). Patients with
      a preoperative nasogastric tube had significantly higher episodes of
      postoperative vomiting (P = .015; 95% confidence interval [CI] 0.29-2.63) and
      length of stay (P = .017; 95% CI, 2.49-25.01). Bicarbonate levels were also
      significantly higher in patients with a nasogastric tube. There was no difference
      in the duration of symptoms, ultrasound characteristics, or type of operation
      between the 2 cohorts. CONCLUSION: The data strongly suggest that preoperative
      nasogastric tube placement adversely affects postoperative vomiting and
      consequently increases length of stay. The lack of consensus about the use of
      preoperative nasogastric tubes coupled with these findings indicates the need to 
      evaluate this practice with a prospective randomized controlled trial.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Elanahas, Ahmad
AU  - Elanahas A
AD  - McMaster University-Hamilton, Ontario, Canada L8N 3Z5.
FAU - Pemberton, Julia
AU  - Pemberton J
FAU - Yousef, Yasmin
AU  - Yousef Y
FAU - Flageole, Helene
AU  - Flageole H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Pediatr Surg
JT  - Journal of pediatric surgery
JID - 0052631
SB  - IM
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Intubation, Gastrointestinal/*adverse effects
MH  - Length of Stay
MH  - Male
MH  - Postoperative Nausea and Vomiting/*etiology
MH  - *Preoperative Care
MH  - Pyloric Stenosis/*surgery
MH  - Retrospective Studies
MH  - Treatment Outcome
EDAT- 2010/05/05 06:00
MHDA- 2010/08/05 06:00
CRDT- 2010/05/05 06:00
PHST- 2010/02/01 00:00 [received]
PHST- 2010/02/03 00:00 [accepted]
PHST- 2010/05/05 06:00 [entrez]
PHST- 2010/05/05 06:00 [pubmed]
PHST- 2010/08/05 06:00 [medline]
AID - S0022-3468(10)00118-1 [pii]
AID - 10.1016/j.jpedsurg.2010.02.026 [doi]
PST - ppublish
SO  - J Pediatr Surg. 2010 May;45(5):1020-3. doi: 10.1016/j.jpedsurg.2010.02.026.


PMID- 20438627
OWN - NLM
STAT- MEDLINE
DCOM- 20110613
LR  - 20211020
IS  - 1747-5341 (Electronic)
IS  - 1747-5341 (Linking)
VI  - 5
DP  - 2010 May 3
TI  - The ethics of everyday practice in primary medical care: responding to social
      health inequities.
PG  - 6
LID - 10.1186/1747-5341-5-6 [doi]
AB  - BACKGROUND: Social and structural inequities shape health and illness; they are
      an everyday presence within the doctor-patient encounter yet, there is limited
      ethical guidance on what individual physicians should do. This paper draws on a
      study that explored how doctors and their professional associations ought to
      respond to the issue of social health inequities. RESULTS: Some see doctors as
      bound by a notion of care that is blind to a patient's social position, while
      others respond to this issue through invoking notions of justice and human rights
      where access to care is a prime focus. Both care and justice orientations however
      conceal important tensions linked to the presence of bioethical principles
      underpinning these. Other normative ethical theories like deontology, virtue
      ethics and utilitarianism do not provide adequate guidance on the problem of
      social health inequities either. CONCLUSION: This paper explores if Bauman's
      notion of "forms of togetherness" provides the basis of a relational ethical
      theory that can help to develop a response to social health inequities of
      relevance to individual physicians. This theory goes beyond silence on the
      influence of social position of health and avoids amoral regulatory approaches to
      monitoring equity of care provision.
FAU - Furler, John S
AU  - Furler JS
AD  - Primary Care Research Unit, The Department of General Practice, The University of
      Melbourne, 200 Berkeley St, Carlton, VIC Australia 3053. j.furler@unimelb.edu.au
FAU - Palmer, Victoria J
AU  - Palmer VJ
LA  - eng
PT  - Journal Article
DEP - 20100503
PL  - England
TA  - Philos Ethics Humanit Med
JT  - Philosophy, ethics, and humanities in medicine : PEHM
JID - 101258058
SB  - IM
MH  - *Ethics, Medical
MH  - *Health Status Disparities
MH  - Human Rights
MH  - Humans
MH  - Moral Obligations
MH  - Morals
MH  - Patient Rights
MH  - Physician's Role
MH  - Physician-Patient Relations
MH  - Primary Health Care/*ethics
MH  - *Social Justice
MH  - Social Responsibility
PMC - PMC2876986
EDAT- 2010/05/05 06:00
MHDA- 2011/06/15 06:00
CRDT- 2010/05/05 06:00
PHST- 2009/10/26 00:00 [received]
PHST- 2010/05/03 00:00 [accepted]
PHST- 2010/05/05 06:00 [entrez]
PHST- 2010/05/05 06:00 [pubmed]
PHST- 2011/06/15 06:00 [medline]
AID - 1747-5341-5-6 [pii]
AID - 10.1186/1747-5341-5-6 [doi]
PST - epublish
SO  - Philos Ethics Humanit Med. 2010 May 3;5:6. doi: 10.1186/1747-5341-5-6.


PMID- 20438608
OWN - NLM
STAT- MEDLINE
DCOM- 20101122
LR  - 20211028
IS  - 1365-2753 (Electronic)
IS  - 1356-1294 (Linking)
VI  - 16
IP  - 3
DP  - 2010 Jun
TI  - So you want to conduct a cluster randomized controlled trial? Lessons from a
      national cluster trial of early labour.
PG  - 632-8
LID - 10.1111/j.1365-2753.2009.01266.x [doi]
AB  - As the discipline of health services research has developed so methods of
      evaluation have become increasingly sophisticated; where once a 'simple'
      randomized controlled trial would have been considered the gold standard, now
      terms such as 'complex interventions' and the 'cluster randomized controlled
      trial' are hot topics for discussion. The challenges involved in carrying out
      such studies are rarely presented. In this paper we discuss some of these
      challenges in relation to ethical and statistical considerations, and illustrate 
      them using a recently completed cluster randomized controlled trial of a decision
      tool for early labour.
FAU - Hundley, Vanora
AU  - Hundley V
AD  - NMAHPRU and Adjunktus Professor, Faculty of Health Sciences, Semmelweis
      University, Budapest, Hungary. vanora.hundley@stir.ac.uk
FAU - Cheyne, Helen
AU  - Cheyne H
FAU - Bland, J Martin
AU  - Bland JM
FAU - Styles, Maggie
AU  - Styles M
FAU - Barnett, Carol A
AU  - Barnett CA
LA  - eng
GR  - CZH/4/417/CSO_/Chief Scientist Office/United Kingdom
GR  - NMAHP2/CSO_/Chief Scientist Office/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100429
PL  - England
TA  - J Eval Clin Pract
JT  - Journal of evaluation in clinical practice
JID - 9609066
SB  - IM
MH  - Bias
MH  - *Cluster Analysis
MH  - Female
MH  - Humans
MH  - Informed Consent
MH  - Labor Onset
MH  - Pregnancy
MH  - Randomized Controlled Trials as Topic/ethics/*methods
MH  - United Kingdom
EDAT- 2010/05/05 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/05/05 06:00
PHST- 2010/05/05 06:00 [entrez]
PHST- 2010/05/05 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - JEP1266 [pii]
AID - 10.1111/j.1365-2753.2009.01266.x [doi]
PST - ppublish
SO  - J Eval Clin Pract. 2010 Jun;16(3):632-8. doi: 10.1111/j.1365-2753.2009.01266.x.
      Epub 2010 Apr 29.


PMID- 20438308
OWN - NLM
STAT- MEDLINE
DCOM- 20100928
LR  - 20161125
IS  - 1557-9034 (Electronic)
IS  - 1092-6429 (Linking)
VI  - 20
IP  - 4
DP  - 2010 May
TI  - Laparoscopic resection of retrocaval paraganglioma.
PG  - 363-7
LID - 10.1089/lap.2010.0013 [doi]
AB  - OBJECTIVES: Definitive treatment of paraganglioma is by surgical resection.
      Laparoscopic resection of the paraganglioma presents a unique surgical challenge 
      due to inherent risks associated with excessive catecholamine release during
      surgical manipulation and variable anatomic presentation. In this report, we
      present our experience with the laparoscopic resection of the retrocaval
      paraganglioma. METHODS: Between October 2001 and November 2007, 2 patients
      underwent the laparoscopic resection of a retrocaval paraganglioma. In both
      cases, the tumors were located just behind the inferior vena cava (IVC) without
      evidence of vessel-wall invasion. The maximum diameter of the tumor was 47 and 44
      mm, respectively. There was extrinsic compression of the IVC in an anterior
      direction by the tumor. To expose the tumor surface completely, the IVC was
      mobilized medially. Thereafter, we proceeded with dissection of the posterior
      attachment of the tumor by using a Harmonic Scalpel (Ethicon, Cincinnati, OH).
      Finally, the tumor and the right adrenal gland were extracted in an endobag.
      RESULTS: In both cases, the tumors were successfully removed laparoscopically
      without the need for conversion or blood transfusion. The operative time was 440 
      and 195 minutes, respectively. There were no significant postoperative
      complications. CONCLUSIONS: To our knowledge, this is the first report of the
      laparoscopic resection of a retrocaval paraganglioma. For the resection of a
      paraganglioma, in this location, laparoscopy has the advantage of precise
      visualization, which helps to resect the tumor completely. Laparoscopic resection
      of a paraganglioma, despite the high level of compression of the IVC, is a
      feasible, reproducible technique with appropriate preoperative planning.
FAU - Nozaki, Tetsuo
AU  - Nozaki T
AD  - Department of Urology, Graduate School of Medicine and Pharmaceutical Sciences
      for Research, University of Toyama, Toyama, Japan. nozaki0921@yahoo.co.jp
FAU - Iida, Hiroaki
AU  - Iida H
FAU - Tsuritani, Shinji
AU  - Tsuritani S
FAU - Okumura, Akiou
AU  - Okumura A
FAU - Komiya, Akira
AU  - Komiya A
FAU - Fuse, Hideki
AU  - Fuse H
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Laparoendosc Adv Surg Tech A
JT  - Journal of laparoendoscopic & advanced surgical techniques. Part A
JID - 9706293
SB  - IM
MH  - Adrenal Gland Neoplasms/diagnostic imaging/*pathology/*surgery
MH  - *Adrenalectomy
MH  - Humans
MH  - *Laparoscopy
MH  - Male
MH  - Middle Aged
MH  - Paraganglioma/diagnostic imaging/*pathology/*surgery
MH  - Radiography
MH  - Vena Cava, Inferior
EDAT- 2010/05/05 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/05/05 06:00
PHST- 2010/05/05 06:00 [entrez]
PHST- 2010/05/05 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - 10.1089/lap.2010.0013 [doi]
PST - ppublish
SO  - J Laparoendosc Adv Surg Tech A. 2010 May;20(4):363-7. doi: 10.1089/lap.2010.0013.


PMID- 20437988
OWN - NLM
STAT- MEDLINE
DCOM- 20100526
LR  - 20211020
IS  - 1470-2118 (Print)
IS  - 1470-2118 (Linking)
VI  - 10
IP  - 2
DP  - 2010 Apr
TI  - New consultant committee representative, Committee for Ethical Issues in
      Medicine.
PG  - 154-5
FAU - Song, Soon H
AU  - Song SH
AD  - Diabetes Centre, Northern General Hospital, Sheffield Teaching Hospitals NHS
      Foundation Trust, Sheffield. Soon.Song@sth.nhs.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Med (Lond)
JT  - Clinical medicine (London, England)
JID - 101092853
SB  - IM
MH  - *Ethics Committees, Clinical/organization & administration
MH  - Humans
MH  - Societies, Medical/organization & administration
MH  - United Kingdom
PMC - PMC4952089
EDAT- 2010/05/05 06:00
MHDA- 2010/05/27 06:00
CRDT- 2010/05/05 06:00
PHST- 2010/05/05 06:00 [entrez]
PHST- 2010/05/05 06:00 [pubmed]
PHST- 2010/05/27 06:00 [medline]
AID - 10.7861/clinmedicine.10-2-154 [doi]
PST - ppublish
SO  - Clin Med (Lond). 2010 Apr;10(2):154-5. doi: 10.7861/clinmedicine.10-2-154.


PMID- 20437980
OWN - NLM
STAT- MEDLINE
DCOM- 20100526
LR  - 20220309
IS  - 1470-2118 (Print)
IS  - 1470-2118 (Linking)
VI  - 10
IP  - 2
DP  - 2010 Apr
TI  - How the NHS research governance procedures could be modified to greatly
      strengthen clinical research.
PG  - 127-9
AB  - Randomised controlled trials are the gold standard for testing the efficacy and
      safety of health interventions, especially medications, and researchers in the
      U.K. are required to gain approval from ethics committees, the regulatory body
      (Medicines and Healthcare products Regulatory Agency) and local NHS research
      governance departments for such trials. Although research governance is important
      to reassure trial participants that their rights and interests are protected,
      current practice is impeding research and presents a genuine threat to the U.K.
      and to the NHS's ability to deliver high-quality evidence on which doctors can
      base clinical decisions and improve the delivery of care. This article discusses 
      recent experience of running large-scale clinical trials and suggests measures
      that could improve the current situation.
FAU - Haynes, Richard
AU  - Haynes R
AD  - Clinical Trial Service Unit, University of Oxford.
FAU - Bowman, Louise
AU  - Bowman L
FAU - Rahimi, Kazem
AU  - Rahimi K
FAU - Armitage, Jane
AU  - Armitage J
LA  - eng
GR  - MC_U137686860/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PL  - England
TA  - Clin Med (Lond)
JT  - Clinical medicine (London, England)
JID - 101092853
SB  - IM
CIN - Clin Med (Lond). 2010 Dec;10(6):637-8. PMID: 21416670
MH  - Clinical Governance/*organization & administration
MH  - Clinical Trials as Topic
MH  - Humans
MH  - Randomized Controlled Trials as Topic
MH  - Research Support as Topic
MH  - State Medicine/*organization & administration
MH  - United Kingdom
PMC - PMC4952081
EDAT- 2010/05/05 06:00
MHDA- 2010/05/27 06:00
CRDT- 2010/05/05 06:00
PHST- 2010/05/05 06:00 [entrez]
PHST- 2010/05/05 06:00 [pubmed]
PHST- 2010/05/27 06:00 [medline]
AID - 10.7861/clinmedicine.10-2-127 [doi]
PST - ppublish
SO  - Clin Med (Lond). 2010 Apr;10(2):127-9. doi: 10.7861/clinmedicine.10-2-127.


PMID- 20437795
OWN - NLM
STAT- MEDLINE
DCOM- 20100607
LR  - 20211020
IS  - 0022-1058 (Print)
IS  - 0022-1058 (Linking)
VI  - 42
IP  - 1
DP  - 2010 Mar
TI  - Arterial filter bypass loop: what occurs in this area during cardiopulmonary
      bypass and are there potential patient implications.
PG  - 71-4
AB  - The arterial filter is an integral part of bypass circuitry. When introduced,
      manufacturers suggested a bypass loop for retrograde priming and de-airing, and
      for uninterrupted blood flow in case of malfunction. Practice has shown antegrade
      priming and de-airing is possible. This questions the necessity of the loop and
      presents the question-what occurs in the loop during bypass? After obtaining
      Human Research Ethics Board approval, eight consecutive patients (n = 8) were
      chosen for this study. Exclusive exclusion criterion was receiving any
      transfusions during cardiopulmonary bypass, as this could possibly influence
      results. The choice of patient numbers was based simply on proof of concept.
      Investigation involved isolation and collection of loop contents after
      cardiopulmonary bypass was completed. Testing included complete blood count,
      prothrombin time, international normalized ratio, partial thromboplastin time,
      activated clotting time, plasma free hemoglobin, slide photography with analysis 
      for platelet clumping, and debris detection. One perfusionist collected samples, 
      providing uniform collection and isolation technique. Regular blood samples were 
      collected from the bypass circuitry, and from patients' pre-operative blood work.
      Analysis of data revealed that platelet counts in the bypass loops were
      statistically lower than control. Evidence of platelet clumping was present in 3 
      of 8 bypass loop samples, representing 37.5% of the study population. There was
      no clumping detected in any of the controls. In patients where platelet clumping 
      was present, a positive correlation was noted between mean bypass time and size
      of platelet clumps. Prothrombin time and international normalized ratio results
      were immeasurable. Hemoglobin levels were higher in the loop samples. There was
      no evidence of debris or fibrin monomer present in any of the samples analyzed.
      The study results indicate that during "normal" cardiopulmonary bypass with an
      arterial filter bypass loop, platelet aggregates can accumulate in the loop,
      therefore opening the arterial bypass loop in any case may subject the patient to
      micro/macro emboli.
FAU - Hawkins, Justin L
AU  - Hawkins JL
AD  - Cardiovascular Perfusion Services, Queen Elizabeth II (QEII) Health Science
      Center, Halifax, Nova Scotia, Canada. jushawk72@hotmail.com
FAU - Myers, Gerard J
AU  - Myers GJ
FAU - Legare, Jean-Francois
AU  - Legare JF
FAU - Swyer, Wilfred
AU  - Swyer W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Extra Corpor Technol
JT  - The journal of extra-corporeal technology
JID - 0267637
MH  - Aged
MH  - *Cardiopulmonary Bypass
MH  - Female
MH  - Humans
MH  - *Platelet Activation
MH  - *Platelet Aggregation
MH  - *Ultrafiltration
PMC - PMC4680069
EDAT- 2010/05/05 06:00
MHDA- 2010/06/09 06:00
CRDT- 2010/05/05 06:00
PHST- 2010/05/05 06:00 [entrez]
PHST- 2010/05/05 06:00 [pubmed]
PHST- 2010/06/09 06:00 [medline]
PST - ppublish
SO  - J Extra Corpor Technol. 2010 Mar;42(1):71-4.


PMID- 20437742
OWN - NLM
STAT- MEDLINE
DCOM- 20100526
LR  - 20190608
IS  - 0027-9684 (Print)
IS  - 0027-9684 (Linking)
VI  - 102
IP  - 4
DP  - 2010 Apr
TI  - Legal ethics for medical practices: regulating restraints of trade for
      physicians.
PG  - 346-7
FAU - Steinbuch, Robert
AU  - Steinbuch R
AD  - William H. Bowen School of Law, University of Arkansas at Little Rock, Little
      Rock, Arkansas 72202, USA. resteinbuch@ualr.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Natl Med Assoc
JT  - Journal of the National Medical Association
JID - 7503090
SB  - IM
CIN - J Natl Med Assoc. 2011 Jul;103(7):623. PMID: 21999041
MH  - American Medical Association
MH  - Contracts/*ethics/legislation & jurisprudence
MH  - *Ethics, Business
MH  - Humans
MH  - Physicians/economics/ethics
MH  - Practice Valuation and Purchase/*ethics/legislation & jurisprudence
MH  - Societies
MH  - United States
EDAT- 2010/05/05 06:00
MHDA- 2010/05/27 06:00
CRDT- 2010/05/05 06:00
PHST- 2010/05/05 06:00 [entrez]
PHST- 2010/05/05 06:00 [pubmed]
PHST- 2010/05/27 06:00 [medline]
AID - S0027-9684(15)30607-6 [pii]
AID - 10.1016/s0027-9684(15)30607-6 [doi]
PST - ppublish
SO  - J Natl Med Assoc. 2010 Apr;102(4):346-7. doi: 10.1016/s0027-9684(15)30607-6.


PMID- 20437658
OWN - NLM
STAT- MEDLINE
DCOM- 20100526
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 7
IP  - 2
DP  - 2010 Apr-Jun
TI  - Safety and ethical issues of bare hand cadaver dissection by medical students.
PG  - 124-5
FAU - Vani, N Isai
AU  - Vani NI
LA  - eng
PT  - Letter
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Anatomy/*education
MH  - *Cadaver
MH  - Dissection/education
MH  - *Education, Medical
MH  - *Gloves, Protective
MH  - Humans
MH  - India
MH  - Infection Control/*methods
EDAT- 2010/05/04 06:00
MHDA- 2010/05/27 06:00
CRDT- 2010/05/04 06:00
PHST- 2010/05/04 06:00 [entrez]
PHST- 2010/05/04 06:00 [pubmed]
PHST- 2010/05/27 06:00 [medline]
AID - 10.20529/IJME.2010.044 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2010 Apr-Jun;7(2):124-5. doi: 10.20529/IJME.2010.044.


PMID- 20437578
OWN - NLM
STAT- MEDLINE
DCOM- 20100514
LR  - 20211020
IS  - 1531-8249 (Electronic)
IS  - 0364-5134 (Linking)
VI  - 67
IP  - 4
DP  - 2010 Apr
TI  - An ethical hierarchy for decision making during medical emergencies.
PG  - 434-40
LID - 10.1002/ana.21997 [doi]
AB  - Evidence from well-designed clinical trials may guide clinicians, reduce regional
      variation, and lead to improved outcomes. Many physicians choose to ignore
      evidence-based practice guidelines. Using unproven therapies outside of a
      randomized trial slows recruitment in clinical trials that could yield
      information on clinical and economic efficacy. Using acute stroke therapy as an
      illustration, we present an ethical hierarchy for therapeutic decision making
      during medical emergencies. First, physicians should offer standard care. If no
      standard care option exists, the physician should consider enrollment in a
      randomized clinical trial. If no trial is appropriate, the physician should
      consider a nonrandomized registry, or consensus-based guidelines. Finally, only
      after considering the first 3 options, the physician should use best judgment
      based on previous personal experience and any published case series or anecdotes.
      Given the paucity of quality randomized clinical trial data for most medical
      decisions, the "best judgment" option will be used most frequently. Nevertheless,
      such a hierarchy is needed because of the limited time during medical emergencies
      for consideration of general principles of clinical decision making. There should
      be general agreement in advance as to the hierarchy to follow in selecting
      treatment for critically ill patients. Were more clinicians to follow this
      hierarchy, and choose to participate in clinical trials, the generation of new
      knowledge would accelerate, yielding rigorous data supporting or refuting the
      efficacy and safety of new interventions more quickly, thus benefiting far more
      patients over time.
FAU - Lyden, Patrick D
AU  - Lyden PD
AD  - Department of Neurosciences, University of California, San Diego School of
      Medicine, La Jolla, CA, USA.
FAU - Meyer, Brett C
AU  - Meyer BC
FAU - Hemmen, Thomas M
AU  - Hemmen TM
FAU - Rapp, Karen S
AU  - Rapp KS
LA  - eng
GR  - P50 NS044148/NS/NINDS NIH HHS/United States
GR  - P50 NS044148-05/NS/NINDS NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Ann Neurol
JT  - Annals of neurology
JID - 7707449
SB  - IM
CIN - Ann Neurol. 2010 Apr;67(4):419-21. PMID: 20437575
MH  - Adult
MH  - Clinical Trials as Topic/*ethics
MH  - Decision Making/*ethics
MH  - Diffusion Magnetic Resonance Imaging/methods
MH  - Emergencies/*psychology
MH  - Humans
MH  - Male
MH  - Paresis/diagnosis/therapy
MH  - Patient Participation
MH  - Physicians/*psychology
PMC - PMC2875330
MID - NIHMS178620
EDAT- 2010/05/04 06:00
MHDA- 2010/05/15 06:00
CRDT- 2010/05/04 06:00
PHST- 2010/05/04 06:00 [entrez]
PHST- 2010/05/04 06:00 [pubmed]
PHST- 2010/05/15 06:00 [medline]
AID - 10.1002/ana.21997 [doi]
PST - ppublish
SO  - Ann Neurol. 2010 Apr;67(4):434-40. doi: 10.1002/ana.21997.


PMID- 20437352
OWN - NLM
STAT- MEDLINE
DCOM- 20120807
LR  - 20100503
IS  - 1090-3941 (Print)
IS  - 1090-3941 (Linking)
VI  - 19
DP  - 2010 Apr
TI  - Introducing the Proceed Ventral Patch as a new device in surgical management of
      umbilical and small ventral hernias: preliminary results.
PG  - 99-103
AB  - Surgical treatment of umbilical and small ventral hernias ranges from a simple
      suture repair to the placement of large intra-abdominal or retromuscular meshes. 
      Several articles report a lower incidence of recurrence after mesh repair,
      whether this is positioned onlay, retromuscular, or intraperitoneally. Often, a
      simple suture repair fails in the longterm, whereas a laparoscopic or
      retromomuscular approach seems too extensive for these rather small hernias. In
      between those two treatment options exists a go-between repair that carries the
      idea of posterior repair without being so aggressive in its approach. In this
      study, the authors examined a new device called the Proceed Ventral Patch (PVP)
      (Ethicon, Inc., Sommerville, NJ, USA). It is a self-expanding, partially
      absorbable, flexible laminate mesh device that allows an easy, quick and minimal 
      invasive, tension-free, and standardized approach to umbilical hernia treatment. 
      No data nor publication exist on this new device. Reported herein is our early
      and first experience with this novel technique.
FAU - Tollens, Tim
AU  - Tollens T
AD  - Imelda Hospital Bonheiden, Belgium.
FAU - Struyve, David
AU  - Struyve D
FAU - Aelvoet, Chris
AU  - Aelvoet C
FAU - Vanrijkel, Jean Pierre
AU  - Vanrijkel JP
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Surg Technol Int
JT  - Surgical technology international
JID - 9604509
SB  - IM
MH  - Absorbable Implants
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Hernia, Umbilical/surgery
MH  - Hernia, Ventral/*surgery
MH  - Humans
MH  - *Laparoscopy/methods
MH  - Male
MH  - Middle Aged
MH  - *Surgical Mesh
MH  - Young Adult
EDAT- 2010/05/04 06:00
MHDA- 2012/08/08 06:00
CRDT- 2010/05/04 06:00
PHST- 2010/05/04 06:00 [entrez]
PHST- 2010/05/04 06:00 [pubmed]
PHST- 2012/08/08 06:00 [medline]
PST - ppublish
SO  - Surg Technol Int. 2010 Apr;19:99-103.


PMID- 20437118
OWN - NLM
STAT- MEDLINE
DCOM- 20101220
LR  - 20211020
IS  - 1572-8633 (Electronic)
IS  - 1386-7423 (Linking)
VI  - 13
IP  - 3
DP  - 2010 Aug
TI  - Human rights from the Nuremberg Doctors Trial to the Geneva Declaration. Persons 
      and institutions in medical ethics and history.
PG  - 259-68
LID - 10.1007/s11019-010-9247-2 [doi]
AB  - The "Universal Declaration of Human Rights" and the "Geneva Declaration" by the
      World Medical Association, both in 1948, were preceded by the foundation of the
      United Nations in New York (1945), the World Medical Association in London (1946)
      and the World Health Organization in Geneva (1948). After the end of World War II
      the community of nations strove to achieve and sustain their primary goals of
      peace and security, as well as their basic premise, namely the health of human
      beings. All these associations were well aware of the crimes by medicine, in
      particular by the accused Nazi physicians at the Nuremberg Doctors Trial
      (1946/47, sentence: August 1947). During the first conference of the World
      Medical Association (September 1947) issues of medical ethics played a major
      role: and a new document was drafted concerning the values of the medical
      profession. After the catastrophe of the War and the criminal activities of
      scientists, the late 1940s saw increased scrutiny paid to fundamental questions
      of human rights and medical ethics, which are still highly relevant for today's
      medicine and morality. The article focuses on the development of medical ethics
      and human rights reflected in the statement of important persons, codes and
      institutions in the field.
FAU - Frewer, Andreas
AU  - Frewer A
AD  - Institut fur Geschichte und Ethik der Medizin, Friedrich-Alexander-University
      Erlangen-Nuremberg, Glueckstr. 10, 91054, Erlangen, Germany.
      andreas.frewer@ethik.med.uni-erlangen.de
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - Netherlands
TA  - Med Health Care Philos
JT  - Medicine, health care, and philosophy
JID - 9815900
SB  - IM
MH  - Ethics, Medical/*history
MH  - History, 20th Century
MH  - Human Rights/*history/legislation & jurisprudence
MH  - Humans
MH  - Internationality/*history/legislation & jurisprudence
MH  - National Socialism/*history
MH  - Physicians/history/legislation & jurisprudence
MH  - World War II
EDAT- 2010/05/04 06:00
MHDA- 2010/12/21 06:00
CRDT- 2010/05/04 06:00
PHST- 2010/05/04 06:00 [entrez]
PHST- 2010/05/04 06:00 [pubmed]
PHST- 2010/12/21 06:00 [medline]
AID - 10.1007/s11019-010-9247-2 [doi]
PST - ppublish
SO  - Med Health Care Philos. 2010 Aug;13(3):259-68. doi: 10.1007/s11019-010-9247-2.


PMID- 20437024
OWN - NLM
STAT- MEDLINE
DCOM- 20101122
LR  - 20211020
IS  - 1433-0385 (Electronic)
IS  - 0009-4722 (Linking)
VI  - 81
IP  - 7
DP  - 2010 Jul
TI  - [Futility: a concept in routine surgery?].
PG  - 643-6
LID - 10.1007/s00104-010-1946-y [doi]
AB  - In surgical practice we are often confronted with ethically challenging
      situations when treating patients not capable of expressing their own wishes.
      Issues of futile treatment by indicating operations arise particularly with
      regard to severe dementia. The concept of futility describes forms of therapy
      which are not appropriate to improve the patient's condition, but for application
      in clinical practice the concept is insufficiently defined.In ethically
      challenging situations, e.g. in the treatment of severely demented patients, we
      need to balance the medical condition and prognosis with the documented or
      assumed wishes of the patients. Involving the relatives competently is essential.
      The indication for surgery in patients with severe dementia, for example, needs
      to be individualized striving for optimal care, a clear communication about
      treatment goals with the relatives and preventing distress and burnout for staff.
      Co-operation with specialists in medical ethics is recommended.
FAU - Mols, A M
AU  - Mols AM
AD  - Viszeralchirurgie, Universitatsspital Basel, Schweiz. molsa@uhbs.ch
FAU - Reiter-Theil, S
AU  - Reiter-Theil S
FAU - Oertli, D
AU  - Oertli D
FAU - Viehl, C T
AU  - Viehl CT
LA  - ger
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - Futility: ein Begriff im chirurgischen Alltag?
PL  - Germany
TA  - Chirurg
JT  - Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
JID - 16140410R
SB  - IM
CIN - Chirurg. 2011 Jan;82(1):80. PMID: 20972530
MH  - Advance Directives/ethics
MH  - Burnout, Professional/prevention & control/psychology
MH  - Caregivers
MH  - Cooperative Behavior
MH  - Dementia/diagnosis
MH  - Ethics Committees
MH  - *Ethics, Medical
MH  - Germany
MH  - Humans
MH  - Ileus/*surgery
MH  - Interdisciplinary Communication
MH  - Medical Futility/*ethics
MH  - Mental Competency
MH  - Neoplasms, Unknown Primary/surgery
MH  - Palliative Care/ethics
MH  - Peritoneal Neoplasms/secondary/surgery
MH  - Professional-Family Relations
MH  - *Proxy
MH  - Referral and Consultation/ethics
MH  - Unnecessary Procedures/ethics
EDAT- 2010/05/04 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/05/04 06:00
PHST- 2010/05/04 06:00 [entrez]
PHST- 2010/05/04 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1007/s00104-010-1946-y [doi]
PST - ppublish
SO  - Chirurg. 2010 Jul;81(7):643-6. doi: 10.1007/s00104-010-1946-y.


PMID- 20436946
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 1949-8357 (Electronic)
IS  - 1949-8357 (Linking)
VI  - 2
IP  - 1
DP  - 2010 Mar 1
TI  - Implementation and Initial Evaluation of an Academic Career Development
      Curriculum for Obstetrics and Gynecology Fellows.
PG  - 133-135
AB  - OBJECTIVE: To develop and evaluate an academic career development curriculum, 25 
      fellows and advanced trainees in nine Obstetrics and Gynecology sub-specialty
      fellowships were surveyed anonymously prior to the start of an academic career
      development common curriculum in 2007. Results were compared to responses from
      the same survey given at the completion of the two-year program in order to guide
      and improve the curriculum. Fourteen surveys were completed for both
      administrations. RESULTS: At each survey time, most fellows expressed the desire 
      to pursue academic careers and planned to present and publish research from their
      fellowship. After the curriculum, there was overall improvement in self-appraised
      confidence for speaking at national meetings and preparing submission of a
      research grant. The most substantial change in self assessment was increased
      awareness and utilization of departmental research support personnel. Areas of
      training that were not the main topic of core sessions, but showed improvement
      were frequency of constructive feedback from mentors and peers, and frequency of 
      discussion of research ethics. CONCLUSION: Institution of an academic career
      development curriculum for Obstetrics and Gynecology fellows was associated with 
      increased self-appraised confidence in specific academic skills as assessed by
      anonymous survey.
FAU - Domino, Steven E
AU  - Domino SE
FAU - Reynolds, R Kevin
AU  - Reynolds RK
LA  - eng
GR  - K12 HD001438/HD/NICHD NIH HHS/United States
GR  - K12 HD001438-10/HD/NICHD NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - J Grad Med Educ
JT  - Journal of graduate medical education
JID - 101521733
PMC - PMC2860319
MID - NIHMS185864
EDAT- 2010/05/04 06:00
MHDA- 2010/05/04 06:01
CRDT- 2010/05/04 06:00
PHST- 2010/05/04 06:00 [entrez]
PHST- 2010/05/04 06:00 [pubmed]
PHST- 2010/05/04 06:01 [medline]
AID - 10.4300/JGME-D-09-00025.1 [doi]
PST - ppublish
SO  - J Grad Med Educ. 2010 Mar 1;2(1):133-135. doi: 10.4300/JGME-D-09-00025.1.


PMID- 20435836
OWN - NLM
STAT- MEDLINE
DCOM- 20100517
LR  - 20211020
IS  - 1942-5546 (Electronic)
IS  - 0025-6196 (Linking)
VI  - 85
IP  - 5
DP  - 2010 May
TI  - Ethics consultation at a large urban public teaching hospital.
PG  - 433-8
LID - 10.4065/mcp.2009.0324 [doi]
AB  - OBJECTIVES: To describe the population served and issues encountered by Hospital 
      Ethics Committee consultation, to describe the incidence of consultation per
      hospital admission, and to describe the resource utilization per consult.
      PATIENTS AND METHODS: This is a retrospective review of all ethics consults at a 
      large urban teaching hospital and level one trauma center in a metropolitan area 
      from January 1, 2004, through December 31, 2006. The data points analyzed were
      patient demographics, time spent by consultants (resource utilization), and the
      choice to pursue a full consult, which differs from a brief consult by the number
      of ethics consultants involved and the formality of the deliberative process.
      RESULTS: A total of 285 consults were conducted or 0.16% (95% confidence
      interval, 0.14%-0.18%) of all hospital admissions. The highest incidence was
      0.88% (95% confidence interval, 0.59%-1.3%) for the trauma intensive care unit.
      The average age of patients consulted on was 51 years, and 54% were in the
      intensive care unit. Of the consults, 90% were brief, and 52% were requested by
      house staff. Consultants logged 60,368 minutes, 38% of which were devoted to full
      consults (10% of total). Consults in obstetrics, general medicine, and surgery
      were the most time-consuming. Pregnancy and human immunodeficiency virus were
      more prevalent in full consults. The "classic" ethics cases of confidentiality
      (5%), patients requesting futile treatment (5%), brain death (4%), error
      disclosure (1%), and organ-donor rights (0.3%) were marginal in our series.
      CONCLUSION: Little data exist on the practice of ethics consultation services. To
      our knowledge, this series represents the largest to date. Specific issues,
      patient characteristics, and hospital services were more prevalent in the most
      time-consuming consults. These data can be used to target the education of
      residents and inform hospital quality initiatives.
FAU - Tapper, Elliot B
AU  - Tapper EB
AD  - Division of Plastic Surgery, Brigham and Women's Hospital, 75 Francis St, Boston,
      MA 02115, USA.
FAU - Vercler, Christian J
AU  - Vercler CJ
FAU - Cruze, Deborah
AU  - Cruze D
FAU - Sexson, William
AU  - Sexson W
LA  - eng
PT  - Journal Article
PL  - England
TA  - Mayo Clin Proc
JT  - Mayo Clinic proceedings
JID - 0405543
SB  - IM
CIN - Indian J Med Ethics. 2010 Oct-Dec;7(4):251-2. PMID: 22106582
MH  - Adult
MH  - Ethics Committees, Clinical/*statistics & numerical data
MH  - Female
MH  - Georgia
MH  - Hospitals, Public/*ethics/statistics & numerical data
MH  - Hospitals, Teaching/*ethics/statistics & numerical data
MH  - Humans
MH  - Intensive Care Units/ethics/statistics & numerical data
MH  - Internship and Residency/ethics/statistics & numerical data
MH  - Male
MH  - Middle Aged
MH  - Pregnancy
MH  - Retrospective Studies
MH  - Time Factors
MH  - Trauma Centers/ethics/statistics & numerical data
MH  - Urban Population
PMC - PMC2861972
EDAT- 2010/05/04 06:00
MHDA- 2010/05/18 06:00
CRDT- 2010/05/04 06:00
PHST- 2010/05/04 06:00 [entrez]
PHST- 2010/05/04 06:00 [pubmed]
PHST- 2010/05/18 06:00 [medline]
AID - S0025-6196(11)60329-7 [pii]
AID - 10.4065/mcp.2009.0324 [doi]
PST - ppublish
SO  - Mayo Clin Proc. 2010 May;85(5):433-8. doi: 10.4065/mcp.2009.0324.


PMID- 20435714
OWN - NLM
STAT- MEDLINE
DCOM- 20110503
LR  - 20161020
IS  - 1526-3347 (Electronic)
IS  - 0191-9601 (Linking)
VI  - 31
IP  - 5
DP  - 2010 May
TI  - Ethics for the pediatrician: the persuasion of enhancements in pediatrics.
PG  - 216-8
LID - 10.1542/pir.31-5-216 [doi]
FAU - Yates, Ferdinand D Jr
AU  - Yates FD Jr
AD  - State University of New York at Buffalo, NY, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pediatr Rev
JT  - Pediatrics in review
JID - 8103046
RN  - 0 (Recombinant Proteins)
RN  - 12629-01-5 (Human Growth Hormone)
SB  - IM
MH  - Biomedical Enhancement/*ethics
MH  - Body Height/*drug effects
MH  - Child
MH  - *Ethics, Medical
MH  - Genetic Enhancement/ethics
MH  - Human Growth Hormone/therapeutic use
MH  - Humans
MH  - Pediatrics/*ethics
MH  - Persuasive Communication
MH  - Recombinant Proteins/therapeutic use
MH  - United States
EDAT- 2010/05/04 06:00
MHDA- 2011/05/04 06:00
CRDT- 2010/05/04 06:00
PHST- 2010/05/04 06:00 [entrez]
PHST- 2010/05/04 06:00 [pubmed]
PHST- 2011/05/04 06:00 [medline]
AID - 31/5/216 [pii]
AID - 10.1542/pir.31-5-216 [doi]
PST - ppublish
SO  - Pediatr Rev. 2010 May;31(5):216-8. doi: 10.1542/pir.31-5-216.


PMID- 20435150
OWN - NLM
STAT- MEDLINE
DCOM- 20101223
LR  - 20100830
IS  - 1873-488X (Electronic)
IS  - 1056-8719 (Linking)
VI  - 62
IP  - 1
DP  - 2010 Jul-Aug
TI  - An integrated system for video and telemetric electroencephalographic recording
      to measure behavioural and physiological parameters.
PG  - 64-71
LID - 10.1016/j.vascn.2010.04.004 [doi]
AB  - INTRODUCTION: The combined evaluation of physiology and behaviour allows a
      complete and more comprehensive pre-clinical assessment of central nervous system
      (CNS) function. An integrated video-telemetric electroencephalography
      (Video-tEEG) system, which allows the simultaneous and continuous recording of
      EEG and video images for long periods, was developed. METHODS: This study focuses
      on the refinement of the surgical methodology for the combined recording of
      cortical, hippocampal EEG and electromyogram (EMG) waveforms in freely moving
      rats. The post-operative recovery of animals was monitored by recording EEGs by
      telemetry and the general activity by video, on days 1, 6 and 15 after surgery,
      for approximately 24h, on each occasion. RESULTS: The results suggested that the 
      applied surgical technique for the implantation of the telemetric transmitter,
      allowed for a gradual recovery of the animals within 15days. During the recovery 
      period the behavioural and locomotor parameters measured, indicated that there
      were no changes to the light-dark circadian cycle, and these parameters gradually
      tended to reach background levels within a 15-day period. Using a mechanical
      connection between the deep and the telemetric electrodes, 15days after surgical 
      implantation the recording system was able to acquire cortical and hippocampal
      EEG traces of good quality. DISCUSSION: This present study is concerned with the 
      refinement of the surgical technique, as well as the integration and
      synchronisation of the commercially available Dataquest telemetry system and the 
      Noldus video system, in order to study cortical, hippocampal EEG waveforms, in
      combination with behaviour and locomotion. The application of this integrated
      Video-tEEG system could provide advantages in the ethical use of animals in
      different pre-clinical research areas.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Moscardo, Elena
AU  - Moscardo E
AD  - Safety Pharmacology, Safety Assessment Department, GlaxoSmithKline R&D Centre,
      Via A. Fleming 4, 37135 Verona, Italy. elena.2.moscardo@gsk.com
FAU - Rostello, Chiara
AU  - Rostello C
LA  - eng
PT  - Journal Article
DEP - 20100508
PL  - United States
TA  - J Pharmacol Toxicol Methods
JT  - Journal of pharmacological and toxicological methods
JID - 9206091
SB  - IM
MH  - Animals
MH  - *Behavior, Animal
MH  - Electrodes, Implanted/veterinary
MH  - *Electroencephalography
MH  - Male
MH  - Monitoring, Physiologic/*methods
MH  - *Motor Activity
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - *Telemetry
MH  - *Video Recording
EDAT- 2010/05/04 06:00
MHDA- 2010/12/25 06:00
CRDT- 2010/05/04 06:00
PHST- 2009/12/17 00:00 [received]
PHST- 2010/02/17 00:00 [accepted]
PHST- 2010/05/04 06:00 [entrez]
PHST- 2010/05/04 06:00 [pubmed]
PHST- 2010/12/25 06:00 [medline]
AID - S1056-8719(10)00063-8 [pii]
AID - 10.1016/j.vascn.2010.04.004 [doi]
PST - ppublish
SO  - J Pharmacol Toxicol Methods. 2010 Jul-Aug;62(1):64-71. doi:
      10.1016/j.vascn.2010.04.004. Epub 2010 May 8.


PMID- 20434710
OWN - NLM
STAT- MEDLINE
DCOM- 20100513
LR  - 20220129
IS  - 1474-5488 (Electronic)
IS  - 1470-2045 (Linking)
VI  - 11
IP  - 5
DP  - 2010 May
TI  - The ethical and scientific case for phase 2C clinical trials.
PG  - 410-1
LID - 10.1016/S1470-2045(10)70093-0 [doi]
FAU - Zee, Ying-Kiat
AU  - Zee YK
FAU - Chan, Sarah W
AU  - Chan SW
FAU - Harris, John
AU  - Harris J
FAU - Jayson, Gordon C
AU  - Jayson GC
LA  - eng
GR  - 087439/WT_/Wellcome Trust/United Kingdom
GR  - G0601746/MRC_/Medical Research Council/United Kingdom
PT  - Letter
PL  - England
TA  - Lancet Oncol
JT  - The Lancet. Oncology
JID - 100957246
SB  - IM
MH  - Clinical Trials, Phase II as Topic/*ethics
MH  - *Ethics, Research
MH  - Humans
MH  - Neoplasms/*therapy
EDAT- 2010/05/04 06:00
MHDA- 2010/05/14 06:00
CRDT- 2010/05/04 06:00
PHST- 2010/05/04 06:00 [entrez]
PHST- 2010/05/04 06:00 [pubmed]
PHST- 2010/05/14 06:00 [medline]
AID - S1470-2045(10)70093-0 [pii]
AID - 10.1016/S1470-2045(10)70093-0 [doi]
PST - ppublish
SO  - Lancet Oncol. 2010 May;11(5):410-1. doi: 10.1016/S1470-2045(10)70093-0.


PMID- 20433984
OWN - NLM
STAT- MEDLINE
DCOM- 20100723
LR  - 20181201
IS  - 1558-0512 (Electronic)
IS  - 0011-8532 (Linking)
VI  - 54
IP  - 2
DP  - 2010 Apr
TI  - Endodontic and implant algorithms.
PG  - 401-13
LID - 10.1016/j.cden.2009.12.008 [doi]
AB  - Dental professionals are often faced with challenges when formulating a treatment
      plan for patients presenting with a compromised tooth. A common dilemma involves 
      the decision between tooth retention using endodontic treatment with crown
      restoration, and extraction and an implant-borne restoration. In this article the
      authors evaluate the 2 treatment modes, and observe that because outcomes are
      similar with both treatments, decisions should be based on the patient's informed
      decision concerning restorability, costs associated with the procedures,
      esthetics, potential adverse outcomes, and ethical factors.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Bowles, W R
AU  - Bowles WR
AD  - Department of Restorative Sciences, University of Minnesota School of Dentistry, 
      515 Delaware Street SE, Minneapolis, MN 55455, USA. bowle001@umn.edu
FAU - Drum, Melissa
AU  - Drum M
FAU - Eleazer, P D
AU  - Eleazer PD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Dent Clin North Am
JT  - Dental clinics of North America
JID - 0217440
RN  - 0 (Dental Implants)
SB  - IM
MH  - Costs and Cost Analysis
MH  - Decision Making
MH  - Dental Implants/*statistics & numerical data
MH  - Humans
MH  - Patient Preference
MH  - Root Canal Therapy/*statistics & numerical data
MH  - Treatment Outcome
EDAT- 2010/05/04 06:00
MHDA- 2010/07/24 06:00
CRDT- 2010/05/04 06:00
PHST- 2010/05/04 06:00 [entrez]
PHST- 2010/05/04 06:00 [pubmed]
PHST- 2010/07/24 06:00 [medline]
AID - S0011-8532(09)00127-X [pii]
AID - 10.1016/j.cden.2009.12.008 [doi]
PST - ppublish
SO  - Dent Clin North Am. 2010 Apr;54(2):401-13. doi: 10.1016/j.cden.2009.12.008.


PMID- 20433728
OWN - NLM
STAT- MEDLINE
DCOM- 20110816
LR  - 20220331
IS  - 1471-2288 (Electronic)
IS  - 1471-2288 (Linking)
VI  - 10
DP  - 2010 Apr 30
TI  - Trials within trials? Researcher, funder and ethical perspectives on the
      practicality and acceptability of nesting trials of recruitment methods in
      existing primary care trials.
PG  - 38
LID - 10.1186/1471-2288-10-38 [doi]
AB  - BACKGROUND: Trials frequently encounter difficulties in recruitment, but evidence
      on effective recruitment methods in primary care is sparse. A robust test of
      recruitment methods involves comparing alternative methods using a randomized
      trial, 'nested' in an ongoing 'host' trial. There are potential scientific,
      logistical and ethical obstacles to such studies. METHODS: Telephone interviews
      were undertaken with four groups of stakeholders (funders, principal
      investigators, trial managers and ethics committee chairs) to explore their views
      on the practicality and acceptability of undertaking nested trials of recruitment
      methods. These semi-structured interviews were transcribed and analysed
      thematically. RESULTS: Twenty people were interviewed. Respondents were familiar 
      with recruitment difficulties in primary care and recognised the case for
      'nested' studies to build an evidence base on effective recruitment strategies.
      However, enthusiasm for this global aim was tempered by the challenges of
      implementation. Challenges for host studies included increasing complexity and
      management burden; compatibility between the host and nested study; and the
      impact of the nested study on trial design and relationships with collaborators. 
      For nested recruitment studies, there were concerns that host study investigators
      might have strong preferences, limiting the nested study investigators' control
      over their research, and also concerns about sample size which might limit
      statistical power. Nested studies needed to be compatible with the main trial and
      should be planned from the outset. Good communication and adequate resources were
      seen as important. CONCLUSIONS: Although research on recruitment was welcomed in 
      principle, the issue of which study had control of key decisions emerged as
      critical. To address this concern, it appeared important to align the interests
      of both host and nested studies and to reduce the burden of hosting a recruitment
      trial. These findings should prove useful in devising a programme of research
      involving nested studies of recruitment interventions.
FAU - Graffy, Jonathan
AU  - Graffy J
AD  - NIHR School for Primary Care Research, University of Cambridge, Cambridge, UK.
      jpg43@medschl.cam.ac.uk
FAU - Bower, Peter
AU  - Bower P
FAU - Ward, Elaine
AU  - Ward E
FAU - Wallace, Paul
AU  - Wallace P
FAU - Delaney, Brendan
AU  - Delaney B
FAU - Kinmonth, Ann-Louise
AU  - Kinmonth AL
FAU - Collier, David
AU  - Collier D
FAU - Miller, Julia
AU  - Miller J
LA  - eng
GR  - G0200391/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100430
PL  - England
TA  - BMC Med Res Methodol
JT  - BMC medical research methodology
JID - 100968545
SB  - IM
MH  - Clinical Trials as Topic/ethics/*methods
MH  - Health Services Research
MH  - Humans
MH  - Interviews as Topic
MH  - *Patient Selection/ethics
MH  - *Primary Health Care
MH  - *Research Design
MH  - *Research Personnel
MH  - Research Support as Topic
PMC - PMC2873514
EDAT- 2010/05/04 06:00
MHDA- 2011/08/17 06:00
CRDT- 2010/05/04 06:00
PHST- 2009/09/11 00:00 [received]
PHST- 2010/04/30 00:00 [accepted]
PHST- 2010/05/04 06:00 [entrez]
PHST- 2010/05/04 06:00 [pubmed]
PHST- 2011/08/17 06:00 [medline]
AID - 1471-2288-10-38 [pii]
AID - 10.1186/1471-2288-10-38 [doi]
PST - epublish
SO  - BMC Med Res Methodol. 2010 Apr 30;10:38. doi: 10.1186/1471-2288-10-38.


PMID- 20433672
OWN - NLM
STAT- MEDLINE
DCOM- 20100820
LR  - 20151119
IS  - 1525-1446 (Electronic)
IS  - 0737-1209 (Linking)
VI  - 27
IP  - 2
DP  - 2010 Mar-Apr
TI  - Willingness of university nursing students to volunteer during a pandemic.
PG  - 174-80
LID - 10.1111/j.1525-1446.2010.00839.x [doi]
AB  - OBJECTIVE: The global threat of an influenza pandemic continues to grow and thus 
      universities have begun emergency preparedness planning. This study examined
      stakeholder's knowledge, risk-perception, and willingness to volunteer. DESIGN
      AND SAMPLE: The design of this study is a cross-sectional survey. Questionnaires 
      were sent to 1,512 nursing students and were returned by 484, yielding a response
      rate of 32% for this subgroup. Nursing students may be a much-needed human
      resource in the event of an influenza pandemic. MEASURES: The measurement tool
      was a Web-based questionnaire regarding pandemic influenza designed by a subgroup
      of researchers on the Public Health Response Committee. RESULTS: Most nursing
      students (67.9%) said they were likely to volunteer in the event of a pandemic if
      they were able to do so. An even higher number (77.4%) said they would volunteer 
      if provided protective garments. Overall, 70.7% of students supported the
      proposition that nursing students have a professional obligation to volunteer
      during a pandemic. Nursing students indicated that they have had a wealth of
      volunteer experience in the past and they would apply this service ethic to a
      pandemic situation. CONCLUSIONS: Emergency preparedness competencies should be
      integrated into existing nursing curricula and other health science programs.
      University administrations need to engage in planning to create protocol for
      recruitment, practice, and protection of volunteers.
FAU - Yonge, Olive
AU  - Yonge O
AD  - Academics, University of Alberta, Edmonton, Alberta, Canada.
      olive.yonge@ualberta.ca
FAU - Rosychuk, Rhonda J
AU  - Rosychuk RJ
FAU - Bailey, Tracey M
AU  - Bailey TM
FAU - Lake, Rob
AU  - Lake R
FAU - Marrie, Thomas J
AU  - Marrie TJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Public Health Nurs
JT  - Public health nursing (Boston, Mass.)
JID - 8501498
SB  - IM
MH  - Absenteeism
MH  - Alberta
MH  - *Attitude of Health Personnel
MH  - Clinical Competence
MH  - Cross-Sectional Studies
MH  - Disaster Planning/organization & administration
MH  - Disease Outbreaks/*prevention & control
MH  - Female
MH  - Humans
MH  - Infection Control
MH  - Influenza, Human/*prevention & control
MH  - Male
MH  - Moral Obligations
MH  - Motivation
MH  - Nursing Methodology Research
MH  - Personnel Staffing and Scheduling
MH  - Protective Clothing
MH  - Students, Nursing/*psychology/statistics & numerical data
MH  - Surveys and Questionnaires
MH  - *Universities
MH  - Volunteers/*psychology/statistics & numerical data
EDAT- 2010/05/04 06:00
MHDA- 2010/08/21 06:00
CRDT- 2010/05/04 06:00
PHST- 2010/05/04 06:00 [entrez]
PHST- 2010/05/04 06:00 [pubmed]
PHST- 2010/08/21 06:00 [medline]
AID - PHN839 [pii]
AID - 10.1111/j.1525-1446.2010.00839.x [doi]
PST - ppublish
SO  - Public Health Nurs. 2010 Mar-Apr;27(2):174-80. doi:
      10.1111/j.1525-1446.2010.00839.x.


PMID- 20433110
OWN - NLM
STAT- MEDLINE
DCOM- 20110113
LR  - 20190923
IS  - 0035-8665 (Print)
IS  - 0035-8665 (Linking)
VI  - 156
IP  - 1
DP  - 2010 Mar
TI  - A personal view--6 months in a FOB.
PG  - 57-9
AB  - General Duty Medical Officers (GDMOs) may deploy within days of completing their 
      Entry Officers Course thereby missing the pre-deployment training undertaken by
      the Regiment that they join. They can be attached to a unit that they have never 
      worked with and it is often the first time that they have worked in isolation.
      There is a steep learning curve both medically and militarily. GDMOs have to
      rapidly learn about medical resupply, environmental health, casualty evacuation
      and be prepared for the ethical and moral decisions they will have to make,
      especially when treating local nationals. This article describes the experiences 
      of GDMOs from 16 Medical Support Regiment in Forward Operating Bases on Operation
      Herrick 8 in Helmand Province, Afghanistan. It aims to show that with careful
      thought and preparation future GDMOs can overcome any shortcomings in their
      pre-deployment training or difficulties they may face when working in a FOB.
FAU - Cooper, D J
AU  - Cooper DJ
AD  - GDMO 16 Medical Regiment (MR), Merville Barracks, Colchester, Essex CO2 7NZ.
      djcooper@doctors.org.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - J R Army Med Corps
JT  - Journal of the Royal Army Medical Corps
JID - 7505627
SB  - IM
CIN - J R Army Med Corps. 2010 Mar;156(1):3-4. PMID: 20433097
MH  - *Afghan Campaign 2001-
MH  - Afghanistan
MH  - Humans
MH  - *Military Medicine
MH  - *Military Personnel
MH  - *Physicians
MH  - Professional Competence
MH  - United Kingdom
EDAT- 2010/05/04 06:00
MHDA- 2011/01/14 06:00
CRDT- 2010/05/04 06:00
PHST- 2010/05/04 06:00 [entrez]
PHST- 2010/05/04 06:00 [pubmed]
PHST- 2011/01/14 06:00 [medline]
AID - 10.1136/jramc-156-01-14 [doi]
PST - ppublish
SO  - J R Army Med Corps. 2010 Mar;156(1):57-9. doi: 10.1136/jramc-156-01-14.


PMID- 20432887
OWN - NLM
STAT- MEDLINE
DCOM- 20100526
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 7
IP  - 2
DP  - 2010 Apr-Jun
TI  - Ethical review, remit and responsibility in biomedical research in South Asia.
PG  - 113-4
FAU - Simpson, Bob
AU  - Simpson B
AD  - Department of Anthropology, Durham University, Durham, United Kingdom.
      robert.simpson@durham.ac.uk
FAU - Dissanayake, Vajira H W
AU  - Dissanayake VH
FAU - Douglas-Jones, Rachel
AU  - Douglas-Jones R
FAU - Sariola, Salla
AU  - Sariola S
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Asia
MH  - Education
MH  - Ethics Committees, Research/*standards
MH  - Humans
MH  - *International Cooperation
MH  - Peer Review, Research/*standards
EDAT- 2010/05/04 06:00
MHDA- 2010/05/27 06:00
CRDT- 2010/05/04 06:00
PHST- 2010/05/04 06:00 [entrez]
PHST- 2010/05/04 06:00 [pubmed]
PHST- 2010/05/27 06:00 [medline]
AID - 10.20529/IJME.2010.042 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2010 Apr-Jun;7(2):113-4. doi: 10.20529/IJME.2010.042.


PMID- 20432884
OWN - NLM
STAT- MEDLINE
DCOM- 20100526
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 7
IP  - 2
DP  - 2010 Apr-Jun
TI  - Issues related to non-heart-beating organ donation.
PG  - 104-6
AB  - Since the enactment of the Transplantation of Human Organs Act, 1994, the brain
      dead person remains the primary source of organs legally obtained for
      transplantation purposes in India. With the increasing demand of organs for
      transplantation purposes, non-heart-beating donors can help meet this need.
      However, the process of retrieving organs in non-heart-beating donors is more
      complex and raises ethical and legal as well as medical issues. This essay
      discusses some of these concerns.
FAU - Bardale, Rajesh
AU  - Bardale R
AD  - Department of Forensic Medicine, Government Medical College and Hospital, Nagpur,
      India. bardalerv@yahoo.co.in
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
CIN - Indian J Med Ethics. 2010 Apr-Jun;7(2):106-7. PMID: 20432885
MH  - *Heart Arrest
MH  - Humans
MH  - India
MH  - Tissue Donors/ethics/supply & distribution
MH  - Tissue and Organ Procurement/*ethics/*legislation & jurisprudence
EDAT- 2010/05/04 06:00
MHDA- 2010/05/27 06:00
CRDT- 2010/05/04 06:00
PHST- 2010/05/04 06:00 [entrez]
PHST- 2010/05/04 06:00 [pubmed]
PHST- 2010/05/27 06:00 [medline]
AID - 10.20529/IJME.2010.035 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2010 Apr-Jun;7(2):104-6. doi: 10.20529/IJME.2010.035.


PMID- 20432878
OWN - NLM
STAT- MEDLINE
DCOM- 20100526
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 7
IP  - 2
DP  - 2010 Apr-Jun
TI  - Is there an elephant in the room? Boundary violations in the doctor-patient
      relationship in India.
PG  - 76-81
AB  - An anonymous postal survey on the awareness of the occurrence of nonsexual and
      sexual boundary violations (NSBV and SBV) in the doctor-patient relationship in
      India was conducted with psychiatrists and psychologists working in the state of 
      Karnataka in India (n=51). Though this was not designed to be a prevalence study 
      on violations, the results suggest that both NSBV and SBVdo occur and, more
      importantly, respondents felt that this is an area which needs urgent attention
      in India. There was disagreement on whether some behaviours in certain situations
      could be construed as NSBV in the Indian culture. Though several respondents
      agreed that there was a need to develop guidelines on this issue in India, there 
      was a perception that the problem was not in the availability of guidelines but
      in their implementation. The ethical implications of the study are discussed.
FAU - Kurpad, Sunita Simon
AU  - Kurpad SS
AD  - Department of Psychiatry, St John's Medical College Hospital, Bangalore, India.
      sunita_simon@hotmail.com
FAU - Machado, Tanya
AU  - Machado T
FAU - Galgali, R B
AU  - Galgali RB
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
CIN - Indian J Med Ethics. 2010 Jul-Sep;7(3):172. PMID: 20806527
CIN - Indian J Med Ethics. 2010 Jul-Sep;7(3):192. PMID: 20806535
CIN - Indian J Med Ethics. 2011 Jan-Mar;8(1):62-3. PMID: 22106606
MH  - Female
MH  - Health Care Surveys
MH  - Humans
MH  - India
MH  - Male
MH  - Physician-Patient Relations/*ethics
MH  - *Psychiatry/ethics/standards
MH  - *Psychology/ethics/standards
MH  - *Sexual Harassment
MH  - *Social Behavior
EDAT- 2010/05/04 06:00
MHDA- 2010/05/27 06:00
CRDT- 2010/05/04 06:00
PHST- 2010/05/04 06:00 [entrez]
PHST- 2010/05/04 06:00 [pubmed]
PHST- 2010/05/27 06:00 [medline]
AID - 10.20529/IJME.2010.029 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2010 Apr-Jun;7(2):76-81. doi: 10.20529/IJME.2010.029.


PMID- 20432834
OWN - NLM
STAT- MEDLINE
DCOM- 20100507
LR  - 20100503
IS  - 0023-7205 (Print)
IS  - 0023-7205 (Linking)
VI  - 107
IP  - 12
DP  - 2010 Mar 24-30
TI  - [The apathetic children--mass-medial infection and medical ethics].
PG  - 843-4
FAU - Bodegard, Goran
AU  - Bodegard G
AD  - BUP-kliniken NVSO, Stockholm. goran.bodegard@comhem.se
LA  - swe
PT  - Journal Article
TT  - De apatiska barnen--medial smitta och medicinsk etik.
PL  - Sweden
TA  - Lakartidningen
JT  - Lakartidningen
JID - 0027707
SB  - IM
MH  - Child
MH  - *Child Behavior Disorders/diagnosis
MH  - Ethics, Medical
MH  - Humans
MH  - Mass Media
MH  - *Refugees/psychology
MH  - Sweden/epidemiology
EDAT- 2010/05/04 06:00
MHDA- 2010/05/08 06:00
CRDT- 2010/05/04 06:00
PHST- 2010/05/04 06:00 [entrez]
PHST- 2010/05/04 06:00 [pubmed]
PHST- 2010/05/08 06:00 [medline]
PST - ppublish
SO  - Lakartidningen. 2010 Mar 24-30;107(12):843-4.


PMID- 20432080
OWN - NLM
STAT- MEDLINE
DCOM- 20100809
LR  - 20211020
IS  - 1464-5351 (Electronic)
IS  - 1369-1058 (Linking)
VI  - 12
IP  - 5
DP  - 2010 Jun
TI  - Engendering care: HIV, humanitarian assistance in Africa and the reproduction of 
      gender stereotypes.
PG  - 555-68
LID - 10.1080/13691051003768140 [doi]
AB  - This paper draws upon recent research in Durban, South Africa to unravel the
      complexities of care ethics in the context of humanitarian aid. It investigates
      how the gendering of care shapes the provision of aid in the context of the HIV
      in Africa constructing an image of 'virile' and 'violent' African masculinity.
      Humanitarian organisations construct imagined relations of caring, invoking
      notions of a shared humanity as informing the imperative to facilitate change.
      This paper draws on varied examples of research and NGO activity to illustrate
      how these relations of care are strongly gendered. Humanitarian interventions
      that invoke universalising conceptions of need could instead draw on feminist
      care ethics that seeks to balance rights, justice and care in ways that attend to
      the webs of relationships through which specific lived realities are shaped.
      Essentialising feminized discourses on care result in a skewed analysis of
      international crises that invariably construct women (and children) as victims in
      need of care, which at best ignore the lived experiences of men and, at worst,
      cast men as virile and violent vectors of disease and social disorder.
FAU - Mindry, Deborah
AU  - Mindry D
AD  - Program in Global Health, University of California, Los Angeles, USA.
      dmindry@ucla.edu
LA  - eng
GR  - T32 MH080634/MH/NIMH NIH HHS/United States
GR  - T32 MH080634-01A1/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - Cult Health Sex
JT  - Culture, health & sexuality
JID - 100883416
SB  - IM
MH  - Adult
MH  - *Altruism
MH  - Catchment Area, Health
MH  - Female
MH  - HIV Infections/*epidemiology
MH  - *Helping Behavior
MH  - Humans
MH  - Male
MH  - *Sexual Behavior
MH  - South Africa/epidemiology
MH  - *Stereotyping
PMC - PMC4154477
MID - NIHMS318778
EDAT- 2010/05/01 06:00
MHDA- 2010/08/10 06:00
CRDT- 2010/05/01 06:00
PHST- 2010/05/01 06:00 [entrez]
PHST- 2010/05/01 06:00 [pubmed]
PHST- 2010/08/10 06:00 [medline]
AID - 921715614 [pii]
AID - 10.1080/13691051003768140 [doi]
PST - ppublish
SO  - Cult Health Sex. 2010 Jun;12(5):555-68. doi: 10.1080/13691051003768140.


PMID- 20431918
OWN - NLM
STAT- MEDLINE
DCOM- 20100928
LR  - 20211020
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 22
IP  - 1
DP  - 2010 Mar
TI  - Curbside consultation re-imagined: Borrowing from the conflict management
      toolkit.
PG  - 41-9
LID - 10.1007/s10730-010-9120-y [doi]
AB  - Curbside ethics consultations occur when an ethics consultant provides guidance
      to a party who seeks assistance over ethical concerns in a case, without the
      consultant involving other stakeholders, conducting his or her own comprehensive 
      review of the case, or writing a chart note. Some have argued that curbside
      consultation is problematic because the consultant, in focusing on a single
      narrative offered by the party seeking advice, necessarily fails to account for
      the full range of moral perspectives. Their concern is that any guidance offered 
      by the ethics consultant will privilege and empower one party's viewpoint
      over-and to the exclusion of-other stakeholders. This could lead to serious
      harms, such as the ethicist being reduced to a means to an end for a clinician
      seeking to achieve his or her own preferred outcome, the ethicist denying the
      broader array of stakeholders input in the process, or the ethicist providing
      wrongheaded or biased advice, posing dangers to the ethical quality of
      decision-making. Although these concerns are important and must be addressed, we 
      suggest that they are manageable. This paper proposes using conflict coaching, a 
      practice developed within the discipline of conflict management, to mitigate the 
      risks posed by curbside consultation, and thereby create new "spaces" for moral
      discourse in the care of patients. Thinking of curbside consultations as an
      opportunity for "clinical ethics conflict coaching" can more fully integrate
      ethics committee members into the daily ethics of patient care and reduce the
      frequency of ethically harmful outcomes.
FAU - Edelstein, Lauren M
AU  - Edelstein LM
AD  - Johns Hopkins' Howard County General Hospital, Columbia, MD 21044, USA.
      lauren.m.edelstein@gmail.com
FAU - Lynch, John J
AU  - Lynch JJ
FAU - Mokwunye, Nneka O
AU  - Mokwunye NO
FAU - DeRenzo, Evan G
AU  - DeRenzo EG
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - *Conflict, Psychological
MH  - *Ethics Consultation
MH  - *Ethics, Clinical
MH  - Humans
MH  - Interprofessional Relations
MH  - *Problem Solving
MH  - United States
EDAT- 2010/05/01 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/05/01 06:00
PHST- 2010/05/01 06:00 [entrez]
PHST- 2010/05/01 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - 10.1007/s10730-010-9120-y [doi]
PST - ppublish
SO  - HEC Forum. 2010 Mar;22(1):41-9. doi: 10.1007/s10730-010-9120-y.


PMID- 20431917
OWN - NLM
STAT- MEDLINE
DCOM- 20100928
LR  - 20211020
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 22
IP  - 1
DP  - 2010 Mar
TI  - Hiring a hospital staff clinical ethicist: creating a formalized behavioral
      interview model.
PG  - 51-63
LID - 10.1007/s10730-010-9121-x [doi]
AB  - This paper presents the behavioral interview model that we developed to formalize
      our hiring practices when we, most recently, needed to hire a new clinical
      ethicist to join our staff at the Center for Ethics at Washington Hospital
      Center.
FAU - Mokwunye, Nneka O
AU  - Mokwunye NO
AD  - Bioethics and Spiritual Care Departments, Washington Hospital Center, DC 20010,
      USA. Nneka.O.Mokwunye@Medstar.net
FAU - Brown, Virginia A
AU  - Brown VA
FAU - Lynch, John J
AU  - Lynch JJ
FAU - DeRenzo, Evan G
AU  - DeRenzo EG
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - District of Columbia
MH  - *Ethicists
MH  - Humans
MH  - Interviews as Topic/*methods
MH  - Personnel Administration, Hospital
MH  - *Personnel Selection
EDAT- 2010/05/01 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/05/01 06:00
PHST- 2010/05/01 06:00 [entrez]
PHST- 2010/05/01 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - 10.1007/s10730-010-9121-x [doi]
PST - ppublish
SO  - HEC Forum. 2010 Mar;22(1):51-63. doi: 10.1007/s10730-010-9121-x.


PMID- 20431916
OWN - NLM
STAT- MEDLINE
DCOM- 20100928
LR  - 20211020
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 22
IP  - 1
DP  - 2010 Mar
TI  - The clinical ethics credentialing project: preliminary notes from a pilot project
      to establish quality measures for ethics consultation.
PG  - 65-72
LID - 10.1007/s10730-010-9122-9 [doi]
AB  - The Clinical Ethics Credentialing Project (CECP) was intiated in 2007 in response
      to the lack of uniform standards for both the training of clinical ethics
      consultants, and for evaluating their work as consultants. CECP participants, all
      practicing clinical ethics consultants, met monthly to apply a standard
      evaluation instrument, the "QI tool", to their consultation notes. This paper
      describes, from a qualitative perspective, how participants grappled with
      applying standards to their work. Although the process was marked by resistance
      and disagreement, it was also noteworthy for the sustained engagement by
      participants over the year of the project, and a high level of acceptance by its 
      conclusion.
FAU - Swiderski, Deborah M
AU  - Swiderski DM
AD  - dswiders@montefiore.org.
FAU - Ettinger, Katharine M
AU  - Ettinger KM
FAU - Webber, Mayris
AU  - Webber M
FAU - Dubler, Nancy N
AU  - Dubler NN
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - Credentialing
MH  - Ethicists/education/standards
MH  - Ethics Consultation/*standards
MH  - Humans
MH  - New York City
MH  - Pilot Projects
MH  - Quality Assurance, Health Care/*methods
MH  - Reference Standards
EDAT- 2010/05/01 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/05/01 06:00
PHST- 2010/05/01 06:00 [entrez]
PHST- 2010/05/01 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - 10.1007/s10730-010-9122-9 [doi]
PST - ppublish
SO  - HEC Forum. 2010 Mar;22(1):65-72. doi: 10.1007/s10730-010-9122-9.


PMID- 20431450
OWN - NLM
STAT- MEDLINE
DCOM- 20100719
LR  - 20181201
IS  - 1559-7776 (Electronic)
IS  - 1559-7768 (Linking)
VI  - 21
IP  - 2
DP  - 2010 Apr-Jun
TI  - Ethical and attitudinal considerations for critical care nurses regarding
      deactivation of implantable cardioverter-defibrillators.
PG  - 222-6
LID - 10.1097/NCI.0b013e3181c9676e [doi]
FAU - Grant, Marian
AU  - Grant M
AD  - Gilchrist Hospice, 13 Norris Run Ct, Reisterstown, Baltimore, MD 21136, USA.
      msgrant@comcast.net
LA  - eng
PT  - Journal Article
PL  - United States
TA  - AACN Adv Crit Care
JT  - AACN advanced critical care
JID - 101269322
MH  - *Attitude of Health Personnel
MH  - *Critical Care
MH  - *Defibrillators, Implantable
MH  - *Ethics, Nursing
MH  - Humans
MH  - Nursing Staff, Hospital/*psychology
MH  - Workforce
EDAT- 2010/05/01 06:00
MHDA- 2010/07/20 06:00
CRDT- 2010/05/01 06:00
PHST- 2010/05/01 06:00 [entrez]
PHST- 2010/05/01 06:00 [pubmed]
PHST- 2010/07/20 06:00 [medline]
AID - 10.1097/NCI.0b013e3181c9676e [doi]
AID - 01256961-201004000-00013 [pii]
PST - ppublish
SO  - AACN Adv Crit Care. 2010 Apr-Jun;21(2):222-6. doi: 10.1097/NCI.0b013e3181c9676e.


PMID- 20431383
OWN - NLM
STAT- MEDLINE
DCOM- 20100809
LR  - 20220309
IS  - 1532-0987 (Electronic)
IS  - 0891-3668 (Linking)
VI  - 29
IP  - 5
DP  - 2010 May
TI  - Randomized trials to study the nonspecific effects of vaccines in children in
      low-income countries.
PG  - 457-61
LID - 10.1097/INF.0b013e3181c91361 [doi]
AB  - The Expanded Program on Immunization (EPI) has led to large reductions in
      morbidity and mortality among children in low-income countries. However, the
      basic EPI schedule may no longer be optimal because of changes in vaccines,
      programs, and epidemiologic circumstances. In addition, evidence has accumulated 
      that some EPI vaccines may have nonspecific effects that increase or decrease
      mortality from subsequent infections with other unrelated organisms. There is
      therefore a need for randomized trials to evaluate the effects of alternative EPI
      schedules on all-cause mortality, as well as vaccine efficacy against the target 
      diseases. We have reviewed the available literature on the nonspecific effects of
      vaccines on mortality, and compiled a list of potential trials that might address
      this issue. We have then ranked the trials based on the potential importance of
      the results and the ethical and practical considerations. Trials of early BCG
      vaccination in low-birth-weight babies, early measles vaccination, and altered
      timing of DTP vaccination all have a high priority.
FAU - Shann, Frank
AU  - Shann F
AD  - Intensive Care Unit, Royal Children's Hospital, Melbourne, Australia.
      frank.shann@rch.org.au
FAU - Nohynek, Hanna
AU  - Nohynek H
FAU - Scott, J Anthony
AU  - Scott JA
FAU - Hesseling, Anneke
AU  - Hesseling A
FAU - Flanagan, Katie L
AU  - Flanagan KL
CN  - Working Group on Nonspecific Effects of Vaccines
LA  - eng
GR  - 061089/WT_/Wellcome Trust/United Kingdom
GR  - 081835/WT_/Wellcome Trust/United Kingdom
GR  - MC_U190088485/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Pediatr Infect Dis J
JT  - The Pediatric infectious disease journal
JID - 8701858
RN  - 0 (BCG Vaccine)
RN  - 0 (Diphtheria-Tetanus-Pertussis Vaccine)
RN  - 0 (Measles Vaccine)
RN  - 0 (Vaccines)
SB  - IM
MH  - BCG Vaccine/immunology
MH  - Child
MH  - Child, Preschool
MH  - Communicable Disease Control/methods
MH  - Communicable Diseases/*epidemiology/*mortality
MH  - Developing Countries
MH  - Diphtheria-Tetanus-Pertussis Vaccine/immunology
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Measles Vaccine/immunology
MH  - Randomized Controlled Trials as Topic
MH  - Vaccines/*immunology
RF  - 34
IR  - Aaby P
FIR - Aaby, Peter
IR  - Adjuik M
FIR - Adjuik, Martin
IR  - Almind G
FIR - Almind, Gert
IR  - Andersen PK
FIR - Andersen, Per Kragh
IR  - Bavdekar A
FIR - Bavdekar, Ashish
IR  - Benn CS
FIR - Benn, Christine S
IR  - Evans S
FIR - Evans, Stephen
IR  - Farrington CP
FIR - Farrington, C Paddy
IR  - Fine PE
FIR - Fine, Paul E M
IR  - Firth MJ
FIR - Firth, Martin J
IR  - Flanagan K
FIR - Flanagan, Katie
IR  - Hesseling A
FIR - Hesseling, Anneke
IR  - Hirve S
FIR - Hirve, Siddhivinayak
IR  - Momodou J
FIR - Momodou, Jasseh
IR  - Kallander K
FIR - Kallander, Karin
IR  - Krishnan A
FIR - Krishnan, Anand
IR  - Maehlen J
FIR - Maehlen, Jan
IR  - Masanj a H
FIR - Masanj a, Honorati
IR  - Misra P
FIR - Misra, Puneet
IR  - Moulton LH
FIR - Moulton, Lawrence H
IR  - Mulholland K
FIR - Mulholland, Kim
IR  - Mutua M
FIR - Mutua, Martin
IR  - Nielsen J
FIR - Nielsen, Jens
IR  - Nohynek H
FIR - Nohynek, Hanna
IR  - Owusu-Agyei S
FIR - Owusu-Agyei, Seth
IR  - Ravn H
FIR - Ravn, Henrik
IR  - Razzaque A
FIR - Razzaque, Abdur
IR  - Rodrigues L
FIR - Rodrigues, Laura
IR  - Rodrigues A
FIR - Rodrigues, Amabelia
IR  - Scott A
FIR - Scott, Anthony
IR  - Shann F
FIR - Shann, Frank
IR  - Sie A
FIR - Sie, Ali
IR  - Smith PG
FIR - Smith, Peter G
IR  - Welaga P
FIR - Welaga, Paul
IR  - Williams TN
FIR - Williams, Thomas N
IR  - Yadav K
FIR - Yadav, Kapil
EDAT- 2010/05/01 06:00
MHDA- 2010/08/10 06:00
CRDT- 2010/05/01 06:00
PHST- 2010/05/01 06:00 [entrez]
PHST- 2010/05/01 06:00 [pubmed]
PHST- 2010/08/10 06:00 [medline]
AID - 10.1097/INF.0b013e3181c91361 [doi]
AID - 00006454-201005000-00017 [pii]
PST - ppublish
SO  - Pediatr Infect Dis J. 2010 May;29(5):457-61. doi: 10.1097/INF.0b013e3181c91361.


PMID- 20431160
OWN - NLM
STAT- MEDLINE
DCOM- 20100810
LR  - 20190917
IS  - 0974-7559 (Electronic)
IS  - 0019-6061 (Linking)
VI  - 47
IP  - 4
DP  - 2010 Apr
TI  - MCIs new code of ethics for medical professionals: an exercise in vain or a
      welcome move.
PG  - 329-30
FAU - Vashishtha, Vipin M
AU  - Vashishtha VM
AD  - Mangla Hospital, Bijnor, UP, India. vmv@manglahospital.org
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian Pediatr
JT  - Indian pediatrics
JID - 2985062R
SB  - IM
MH  - *Codes of Ethics
MH  - Drug Industry/ethics
MH  - Health Personnel/*ethics
MH  - Humans
MH  - India
EDAT- 2010/05/01 06:00
MHDA- 2010/08/11 06:00
CRDT- 2010/05/01 06:00
PHST- 2010/05/01 06:00 [entrez]
PHST- 2010/05/01 06:00 [pubmed]
PHST- 2010/08/11 06:00 [medline]
AID - 10.1007/s13312-010-0056-8 [doi]
PST - ppublish
SO  - Indian Pediatr. 2010 Apr;47(4):329-30. doi: 10.1007/s13312-010-0056-8.


PMID- 20430983
OWN - NLM
STAT- MEDLINE
DCOM- 20100511
LR  - 20100430
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Linking)
VI  - 328
IP  - 5978
DP  - 2010 Apr 30
TI  - Ethics. DNA returned to tribe, raising questions about consent.
PG  - 558
LID - 10.1126/science.328.5978.558 [doi]
FAU - Couzin-Frankel, Jennifer
AU  - Couzin-Frankel J
LA  - eng
PT  - News
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Arizona
MH  - Blood Specimen Collection
MH  - *DNA
MH  - Databases, Genetic
MH  - Genetic Research/*ethics
MH  - Humans
MH  - Indians, North American/*genetics
MH  - *Informed Consent
MH  - National Library of Medicine (U.S.)
MH  - United States
MH  - Universities/*ethics/legislation & jurisprudence
EDAT- 2010/05/01 06:00
MHDA- 2010/05/12 06:00
CRDT- 2010/05/01 06:00
PHST- 2010/05/01 06:00 [entrez]
PHST- 2010/05/01 06:00 [pubmed]
PHST- 2010/05/12 06:00 [medline]
AID - 328/5978/558 [pii]
AID - 10.1126/science.328.5978.558 [doi]
PST - ppublish
SO  - Science. 2010 Apr 30;328(5978):558. doi: 10.1126/science.328.5978.558.


PMID- 20430509
OWN - NLM
STAT- MEDLINE
DCOM- 20101122
LR  - 20151119
IS  - 1872-7654 (Electronic)
IS  - 0301-2115 (Linking)
VI  - 151
IP  - 2
DP  - 2010 Aug
TI  - Parental experience following perinatal death: exploring the issues to make
      progress.
PG  - 143-8
LID - 10.1016/j.ejogrb.2010.04.003 [doi]
AB  - OBJECTIVES: This study was performed to understand the parental attitudes, needs 
      and ethical issues associated with perinatal death, to assist in the development 
      of interventions for bereaved families. STUDY DESIGN: We conducted a qualitative 
      descriptive survey of parental experiences with perinatal death. We developed a
      questionnaire based on the Delphi method, conducted semi-directed interviews or
      asked subjects to return the questionnaire by post. As a secondary analysis, we
      examined whether certain ethical principles (i.e., the concepts of beneficence,
      nonmaleficence, autonomy, and justice) were encountered by the study
      participants. The study population consisted of families who had experienced
      perinatal death in the maternity department of a French university hospital, as
      well as members of bereaved parent support groups. RESULTS: Six of the 12 parents
      who participated in the survey were members of a support group. Responses were
      analyzed according to precise objectives and grouped according to key themes. In 
      particular, we studied deaths that occurred during neonatal palliative care and
      deaths relating to multiple pregnancies. Parents expressed opinions about the
      caregivers' practices (e.g., which practices were beneficial and detrimental).
      Half of the parents did not feel that their feelings and decisions were respected
      according to ethical principles. Understanding the experience of parents allows
      staff to reconsider and change their practices. CONCLUSIONS: By understanding
      parents' feelings toward neonatal death, caregivers can better assist with the
      grieving process. Our study reveals parents' attitudes toward the ethical
      decision-making process and shows that it is difficult for perinatal medicine
      caregivers to respect parents' autonomy.
CI  - Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Einaudi, M A
AU  - Einaudi MA
AD  - Department of Pediatrics-Neonatology, Hopital Nord, Universite de la
      Mediterranee, Marseille, France. marieange.einaudi@mail.ap-hm.fr
FAU - Le Coz, P
AU  - Le Coz P
FAU - Malzac, P
AU  - Malzac P
FAU - Michel, F
AU  - Michel F
FAU - D'Ercole, C
AU  - D'Ercole C
FAU - Gire, C
AU  - Gire C
LA  - eng
PT  - Journal Article
DEP - 20100428
PL  - Ireland
TA  - Eur J Obstet Gynecol Reprod Biol
JT  - European journal of obstetrics, gynecology, and reproductive biology
JID - 0375672
SB  - IM
MH  - Attitude to Death
MH  - *Death
MH  - Ethics
MH  - Female
MH  - *Grief
MH  - Humans
MH  - Infant, Newborn
MH  - Interviews as Topic
MH  - Male
MH  - Parents/*psychology
MH  - *Perinatal Mortality
MH  - Pregnancy
MH  - Self-Help Groups
MH  - Surveys and Questionnaires
EDAT- 2010/05/01 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/05/01 06:00
PHST- 2009/09/11 00:00 [received]
PHST- 2010/03/21 00:00 [revised]
PHST- 2010/04/01 00:00 [accepted]
PHST- 2010/05/01 06:00 [entrez]
PHST- 2010/05/01 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S0301-2115(10)00172-7 [pii]
AID - 10.1016/j.ejogrb.2010.04.003 [doi]
PST - ppublish
SO  - Eur J Obstet Gynecol Reprod Biol. 2010 Aug;151(2):143-8. doi:
      10.1016/j.ejogrb.2010.04.003. Epub 2010 Apr 28.


PMID- 20430323
OWN - NLM
STAT- MEDLINE
DCOM- 20100722
LR  - 20151119
IS  - 1934-1482 (Print)
IS  - 1934-1482 (Linking)
VI  - 2
IP  - 4
DP  - 2010 Apr
TI  - Practicing physical medicine and rehabilitation in an ethical manner.
PG  - 229-31
LID - 10.1016/j.pmrj.2010.03.019 [doi]
FAU - Gans, Bruce M
AU  - Gans BM
AD  - Kessler Institute for Rehabilitation and Physical Medicine and Rehabilitation,
      University of Medicine and Dentistry of New Jersey-New Jersey Medical School,
      Newark, NJ 07103, USA. bgans@KESSLER-REHAB.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - PM R
JT  - PM & R : the journal of injury, function, and rehabilitation
JID - 101491319
SB  - IM
MH  - Humans
MH  - Physical and Rehabilitation Medicine/education/*ethics/*organization &
      administration
MH  - Practice Patterns, Physicians'/*ethics
MH  - United States
EDAT- 2010/05/01 06:00
MHDA- 2010/07/23 06:00
CRDT- 2010/05/01 06:00
PHST- 2010/03/19 00:00 [received]
PHST- 2010/03/19 00:00 [accepted]
PHST- 2010/05/01 06:00 [entrez]
PHST- 2010/05/01 06:00 [pubmed]
PHST- 2010/07/23 06:00 [medline]
AID - S1934-1482(10)00230-3 [pii]
AID - 10.1016/j.pmrj.2010.03.019 [doi]
PST - ppublish
SO  - PM R. 2010 Apr;2(4):229-31. doi: 10.1016/j.pmrj.2010.03.019.


PMID- 20430154
OWN - NLM
STAT- MEDLINE
DCOM- 20100810
LR  - 20100430
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 42
IP  - 3
DP  - 2010 Apr
TI  - Organ donation after cardiac death in the Middle East.
PG  - 713-5
LID - 10.1016/j.transproceed.2010.02.058 [doi]
AB  - INTRODUCTION: The shortage of organ donors along with the increased number of
      waiting recipients have created the need for new strategies to expand the organ
      pool: living donors, split livers, domino livers, and organs from donations after
      cardiac death (DCD). The purpose of this article was to focus upon aspects of DCD
      application in the religious, traditional, ethical, and legal aspects of the Arab
      world. BACKGROUND: DCD can increase the donor pool by 15%-25%. Several ethical,
      legal, and social concerns need to be addressed to make DCD more widely accepted 
      by the general population in Western countries as well as in the Middle East.
      Organs from DCD donors have been transplanted since the 1960s. As soon as brain
      death criteria were published in 1968, organ retrieval from cadaveric
      heart-beating donors predominated. Donation after brain death (DBD) almost
      completely replaced DCD. In the 1990s, the organ shortage led to DCD in many
      countries, but not in the Arab world. DCD is still not accepted by most in the
      Arab world due to religious, ethical, social, and legal issues. CONCLUSION: DCD
      in the Arab world is more complicated than in Western countries. It should be
      re-evaluated and thoroughly reviewed with the new criteria for DCD and its
      implementation in our region.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Faraj, W
AU  - Faraj W
AD  - American University of Beirut-Medical Center, Department of Surgery,
      Hepatobiliary and Pancreatic Surgery and Liver Transplant Unit, Beirut, Lebanon. 
      wf07@aub.edu.lb
FAU - Fakih, H
AU  - Fakih H
FAU - Mukherji, D
AU  - Mukherji D
FAU - Khalife, M
AU  - Khalife M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - Arabs/psychology/statistics & numerical data
MH  - Brain Death
MH  - Cadaver
MH  - Death
MH  - Death, Sudden, Cardiac/*epidemiology
MH  - Ethics, Medical
MH  - Humans
MH  - Kidney Transplantation/statistics & numerical data
MH  - Legislation, Medical
MH  - Middle East/epidemiology
MH  - Tissue and Organ Procurement/standards/*statistics & numerical data
EDAT- 2010/05/01 06:00
MHDA- 2010/08/11 06:00
CRDT- 2010/05/01 06:00
PHST- 2010/05/01 06:00 [entrez]
PHST- 2010/05/01 06:00 [pubmed]
PHST- 2010/08/11 06:00 [medline]
AID - S0041-1345(10)00273-3 [pii]
AID - 10.1016/j.transproceed.2010.02.058 [doi]
PST - ppublish
SO  - Transplant Proc. 2010 Apr;42(3):713-5. doi: 10.1016/j.transproceed.2010.02.058.


PMID- 20430113
OWN - NLM
STAT- MEDLINE
DCOM- 20110408
LR  - 20220318
IS  - 1556-3871 (Electronic)
IS  - 1547-5271 (Linking)
VI  - 7
IP  - 11
DP  - 2010 Nov
TI  - Reuse of pacemakers and defibrillators in developing countries: logistical,
      legal, and ethical barriers and solutions.
PG  - 1623-7
LID - 10.1016/j.hrthm.2010.04.027 [doi]
AB  - In the wealthy nations of the world, access to implantable cardiac rhythm
      management devices is widespread. In many underserved low- and middle-income
      countries (LMIC), where cardiovascular disease is fast becoming a major public
      health problem, access is often limited. Reuse of pulse generators was practiced 
      regularly in some European nations in the 1990s with good results. It is
      performed in LMIC, although the rates of device reuse are unknown. The available 
      literature suggests there is no increased risk of morbidity or mortality with the
      reuse of devices. Donations of pacemaker and defibrillator pulse generators from 
      developed nations constitute an important source of devices for the poor in LMIC.
      There are opportunities to increase this supply, but logistical barriers and
      legal and ethical concerns must be addressed. With proper sterilization,
      meticulous chains of custody, and advance directives for device handling
      (pacemaker/defibrillator living wills), patients in LMIC who would otherwise lack
      access to these devices could benefit from their reuse.
CI  - Copyright (c) 2010 Heart Rhythm Society. Published by Elsevier Inc. All rights
      reserved.
FAU - Kirkpatrick, James N
AU  - Kirkpatrick JN
AD  - Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania,
      USA. James.kirkpatrick@uphs.upenn.edu
FAU - Papini, Christina
AU  - Papini C
FAU - Baman, Timir S
AU  - Baman TS
FAU - Kota, Karthik
AU  - Kota K
FAU - Eagle, Kim A
AU  - Eagle KA
FAU - Verdino, Ralph J
AU  - Verdino RJ
FAU - Caplan, Arthur L
AU  - Caplan AL
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100426
PL  - United States
TA  - Heart Rhythm
JT  - Heart rhythm
JID - 101200317
SB  - IM
CIN - Heart Rhythm. 2010 Nov;7(11):1628-9. PMID: 20854929
EIN - Heart Rhythm. 2010 Dec;7(12):1920. Khota, Karthik [corrected to Kota, Karthik]
MH  - Defibrillators/ethics/*statistics & numerical data
MH  - *Developing Countries
MH  - Equipment Reuse/legislation & jurisprudence
MH  - Humans
MH  - Pacemaker, Artificial/ethics/*statistics & numerical data
EDAT- 2010/05/01 06:00
MHDA- 2011/04/09 06:00
CRDT- 2010/05/01 06:00
PHST- 2010/03/12 00:00 [received]
PHST- 2010/04/23 00:00 [accepted]
PHST- 2010/05/01 06:00 [entrez]
PHST- 2010/05/01 06:00 [pubmed]
PHST- 2011/04/09 06:00 [medline]
AID - S1547-5271(10)00402-9 [pii]
AID - 10.1016/j.hrthm.2010.04.027 [doi]
PST - ppublish
SO  - Heart Rhythm. 2010 Nov;7(11):1623-7. doi: 10.1016/j.hrthm.2010.04.027. Epub 2010 
      Apr 26.


PMID- 20429681
OWN - NLM
STAT- MEDLINE
DCOM- 20100823
LR  - 20181201
IS  - 1440-1665 (Electronic)
IS  - 1039-8562 (Linking)
VI  - 18
IP  - 3
DP  - 2010 Jun
TI  - How the philosophy of Merleau-Ponty can help us understand the gulf between
      clinical experience and the doctrine of evidence-based psychotherapy.
PG  - 221-5
LID - 10.3109/10398561003686789 [doi]
AB  - OBJECTIVE: The aim of this paper is to examine the gulf between clinical
      experience and the doctrine of evidence-based psychotherapy from the perspective 
      of the philosophy of Maurice Merleau-Ponty. CONCLUSIONS: Evidence-based
      psychotherapy, which requires that psychotherapists ignore their thoughts and
      feelings with individual patients in favour of following standardized manuals and
      guidelines, is being increasingly promoted as part of evidence-based medicine
      (EBM). However, this represents an inappropriate extension of logical empiricist 
      philosophy and significance testing methodology, on which evidence-based medicine
      is founded, to psychotherapy. It sacrifices a search for truth in psychotherapy, 
      for an illusory search for certainty. The inevitable consequence of this is that 
      psychotherapy becomes a commoditised pseudorelationship. Merleau-Ponty provides
      an alternative ontology, based on the primacy of perception, that gives an
      epistemological foundation for the search for truth and integration as a basis
      for psychotherapy. The practice of evidence-based psychotherapy raises serious
      ethical concerns about pseudorelationships being passed off as authentic, which
      could lead to missed opportunities to engage mentally ill patients in treatment
      and to reinforcement of their damaging sense of alienation.
FAU - Morstyn, Ron
AU  - Morstyn R
AD  - Consultant Psychiatrist and Psychotherapist, Sydney, NSW, Australia.
      ronmorstyn@bigpond.com
LA  - eng
PT  - Journal Article
PL  - England
TA  - Australas Psychiatry
JT  - Australasian psychiatry : bulletin of Royal Australian and New Zealand College of
      Psychiatrists
JID - 9613603
SB  - IM
CIN - Australas Psychiatry. 2011 Feb;19(1):86. PMID: 21303287
MH  - Adaptation, Psychological/ethics
MH  - Anxiety Disorders/psychology/therapy
MH  - Cognitive Behavioral Therapy/ethics
MH  - Depressive Disorder/psychology/therapy
MH  - Empathy
MH  - Empiricism
MH  - Evidence-Based Medicine/*ethics
MH  - Guideline Adherence/ethics
MH  - Humans
MH  - Life Change Events
MH  - Logic
MH  - Manuals as Topic
MH  - Mental Disorders/psychology/*therapy
MH  - *Philosophy, Medical
MH  - Physician-Patient Relations/*ethics
MH  - Psychoanalytic Therapy/*ethics/methods
MH  - Randomized Controlled Trials as Topic/ethics
MH  - Reality Testing
MH  - Treatment Outcome
MH  - Trust/psychology
MH  - Uncertainty
EDAT- 2010/05/01 06:00
MHDA- 2010/08/24 06:00
CRDT- 2010/05/01 06:00
PHST- 2010/05/01 06:00 [entrez]
PHST- 2010/05/01 06:00 [pubmed]
PHST- 2010/08/24 06:00 [medline]
AID - 10.3109/10398561003686789 [doi]
PST - ppublish
SO  - Australas Psychiatry. 2010 Jun;18(3):221-5. doi: 10.3109/10398561003686789.


PMID- 20429488
OWN - NLM
STAT- MEDLINE
DCOM- 20100518
LR  - 20140912
IS  - 0256-9574 (Print)
VI  - 100
IP  - 1
DP  - 2010 Jan
TI  - HIV prevention responsibilities in HIV vaccine trials: complexities facing South 
      African researchers.
PG  - 45-8
AB  - Researchers should protect the welfare of research participants through providing
      methods to reduce their risk of acquiring HIV. This is especially important given
      that late-phase HIV vaccine trials enrol HIV-uninfected trial volunteers from
      high-risk populations. Current ethical guidelines may be difficult for
      stakeholders to implement, and we know very little about what prevention services
      researchers are currently providing to participants or their successes, best
      practices and challenges. We recommend that current normative guidance be
      systematically reviewed and actual practice at vaccine sites be documented.
      Adding new tools to the current package of prevention services will involve
      complex decision making with few set standards, and regulatory and scientific
      challenges. We recommend that stakeholders (including regulators) convene to
      consider standards of evidence for new tools, and that decision-making processes 
      be explicitly documented and researched. A further critical ethical task is
      exploring the threshold at which adding new tools will compromise the validity of
      trial results.
FAU - Essack, Zaynab
AU  - Essack Z
AD  - School of Psychology, University of KwaZulu-Natal, Pietermaritzburg.
      essack@ukzn.ac.za
FAU - Slack, Catherine
AU  - Slack C
FAU - Koen, Jennifer
AU  - Koen J
FAU - Gray, Glenda
AU  - Gray G
LA  - eng
PT  - Journal Article
PT  - Review
PL  - South Africa
TA  - S Afr Med J
JT  - South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
JID - 0404520
RN  - 0 (AIDS Vaccines)
SB  - IM
MH  - *AIDS Vaccines
MH  - Biomedical Research/*ethics
MH  - HIV Infections/*prevention & control
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - *Social Responsibility
MH  - South Africa
RF  - 21
EDAT- 2010/05/01 06:00
MHDA- 2010/05/19 06:00
CRDT- 2010/05/01 06:00
PHST- 2010/05/01 06:00 [entrez]
PHST- 2010/05/01 06:00 [pubmed]
PHST- 2010/05/19 06:00 [medline]
PST - ppublish
SO  - S Afr Med J. 2010 Jan;100(1):45-8.


PMID- 23447759
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130301
LR  - 20211021
IS  - 1524-6205 (Print)
IS  - 1524-6205 (Linking)
VI  - 2010
DP  - 2010 May
TI  - Commentary on "uncovering awareness: medical and ethical challenges in diagnosing
      and treating the minimally conscious state".
PG  - 12
FAU - Schiff, Nicholas D
AU  - Schiff ND
FAU - Posner, Jerome B
AU  - Posner JB
LA  - eng
PT  - Journal Article
DEP - 20100614
PL  - United States
TA  - Cerebrum
JT  - Cerebrum : the Dana forum on brain science
JID - 100888555
PMC - PMC3574779
EDAT- 2010/05/01 00:00
MHDA- 2010/05/01 00:01
CRDT- 2013/03/01 06:00
PHST- 2013/03/01 06:00 [entrez]
PHST- 2010/05/01 00:00 [pubmed]
PHST- 2010/05/01 00:01 [medline]
PST - ppublish
SO  - Cerebrum. 2010 May;2010:12. Epub 2010 Jun 14.


PMID- 21883078
OWN - NLM
STAT- MEDLINE
DCOM- 20111227
LR  - 20110902
IS  - 1543-5237 (Electronic)
IS  - 0367-0244 (Linking)
VI  - 49
IP  - 3
DP  - 2010 May-Jun
TI  - The importance of baobab (Adansonia digitata L.) in rural West African
      subsistence--suggestion of a cautionary approach to international market export
      of baobab fruits.
PG  - 145-72
LID - 10.1080/03670241003766014 [doi]
AB  - The European Commission recently authorized the import of baobab (Adansonia
      digitata L.) fruit pulp as a novel food. In rural West Africa the multipurpose
      baobab is used extensively for subsistence. Three hundred traditional uses of the
      baobab were documented in Benin, Mali, and Senegal across 11 ethnic groups and 4 
      agroecological zones. Baobab fruits and leaves are consumed throughout the year. 
      The export of baobab fruits could negatively influence livelihoods, including
      reduced nutritional intake, change of power relations, and access rights.
      Capacity building and certification could encourage a sustainable and ethical
      trade of baobab fruits without neglecting baobab use in subsistence.
FAU - Buchmann, Christine
AU  - Buchmann C
AD  - University of Natural Resources and Applied Life Sciences, Department of
      Sustainable Agricultural Systems, Division of Organic Farming, Working Group:
      Knowledge Systems and Innovations, Vienna, Austria. christine.buchmann@boku.ac.at
FAU - Prehsler, Sarah
AU  - Prehsler S
FAU - Hartl, Anna
AU  - Hartl A
FAU - Vogl, Christian R
AU  - Vogl CR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ecol Food Nutr
JT  - Ecology of food and nutrition
JID - 0315073
SB  - IM
MH  - *Adansonia
MH  - Africa, Western
MH  - Crops, Agricultural/*economics
MH  - Developing Countries
MH  - Diet/economics/ethnology
MH  - European Union
MH  - Fruit/*economics
MH  - Humans
MH  - Marketing/economics/trends
MH  - Medicine, African Traditional/economics
MH  - Nutritive Value
MH  - Plant Leaves
MH  - Social Change
MH  - Socioeconomic Factors
MH  - Vegetables/economics
EDAT- 2010/05/01 00:00
MHDA- 2011/12/28 06:00
CRDT- 2011/09/03 06:00
PHST- 2011/09/03 06:00 [entrez]
PHST- 2010/05/01 00:00 [pubmed]
PHST- 2011/12/28 06:00 [medline]
AID - 10.1080/03670241003766014 [doi]
PST - ppublish
SO  - Ecol Food Nutr. 2010 May-Jun;49(3):145-72. doi: 10.1080/03670241003766014.


PMID- 21811355
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1998-3735 (Electronic)
IS  - 0973-1075 (Linking)
VI  - 16
IP  - 2
DP  - 2010 May
TI  - Caring for dying and meeting death: experiences of Iranian and Swedish nurses.
PG  - 90-6
LID - 10.4103/0973-1075.68405 [doi]
AB  - OBJECTIVE: Our world is rapidly becoming a global community, which creates a need
      to further understand the universal phenomena of death and professional caring
      for dying persons. This study thus was conducted to describe the meaning of
      nurses' experiences of caring for dying people in the cultural contexts of Iran
      and Sweden. MATERIALS AND METHODS: Using a phenomenological approach, phenomenon 
      of caring for dying people was studied. Eight registered nurses who were working 
      in oncology units in Tehran, Iran and eight registered nurses working in hospital
      and home care in North part of Sweden were interviewed. The interviews were
      analyzed using the principles of phenomenological hermeneutics. RESULTS: THE
      FINDINGS WERE FORMULATED BASED ON TWO THEMES INCLUDED: (1) "Sharing space and
      time to be lost", and (2) "Caring is a learning process. CONCLUSIONS: The results
      showed that being with dying people raise an ethical demand that calls for
      personal and professional response, regardless of sex, culture or context. The
      physical and organizational context must be supportive and enable nurses to stand
      up to the demands of close relationships. Specific units and teamwork across
      various personnel seem to be a solution that is missing in Iran.
FAU - Iranmanesh, Sedigheh
AU  - Iranmanesh S
AD  - Razi Faculty of Nursing and Midwifery, Kerman Medical University, Kerman, Iran.
FAU - Axelsson, Karin
AU  - Axelsson K
FAU - Savenstedt, Stefan
AU  - Savenstedt S
FAU - Haggstrom, Terttu
AU  - Haggstrom T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Indian J Palliat Care
JT  - Indian journal of palliative care
JID - 101261221
PMC - PMC3144438
OTO - NOTNLM
OT  - Caring for dying
OT  - Iranian nurses
OT  - Oncology
OT  - Palliative care
OT  - Swedish nurses
EDAT- 2010/05/01 00:00
MHDA- 2010/05/01 00:01
CRDT- 2011/08/04 06:00
PHST- 2011/08/04 06:00 [entrez]
PHST- 2010/05/01 00:00 [pubmed]
PHST- 2010/05/01 00:01 [medline]
AID - 10.4103/0973-1075.68405 [doi]
AID - IJPC-16-90 [pii]
PST - ppublish
SO  - Indian J Palliat Care. 2010 May;16(2):90-6. doi: 10.4103/0973-1075.68405.


PMID- 21811354
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1998-3735 (Electronic)
IS  - 0973-1075 (Linking)
VI  - 16
IP  - 2
DP  - 2010 May
TI  - Care of Terminally Ill Cancer Patients: An Intensivist's Dilemma.
PG  - 83-9
LID - 10.4103/0973-1075.68406 [doi]
AB  - BACKGROUND AND CONTEXT: Treatment of terminally ill cancer patients always poses 
      great challenges especially when these critical patients are admitted in
      intensive care unit (ICU). The severity of their diseases throws a clinical and
      ethical dilemma to the treating intensivist. AIMS AND OBJECTIVES: To evaluate the
      benefits of intensive care treatment in terminally ill cancer patients and also
      to find out whether optimal utilization of critical care resources has got any
      positive financial, psychological and clinical outcome. MATERIALS AND METHODS: A 
      retrospective evaluation of 53 terminally ill cancer patients, who got admitted
      to ICU of our department, was carried out. Majority of these patients presented
      with terminal phase of illness involving multi-organ pathologies with diverse
      range of symptoms. These patients were provided ventilatory, symptomatic and
      supportive treatment on patient-to-patient basis. Strict and vigilant monitoring 
      of all vital parameters was carried out. At the end of study, all the data was
      compiled systematically and was subjected to statistical analysis using non
      parametric tests. RESULTS: The demographic profile of such patients was highly
      variable with regard to educational, social and financial status (P<0.05). The
      most common group of cancer was hematological malignancies (24.53%) followed by
      lung cancer (18.87%), uteri-ovarian (15.09), colorectal (13.2%) and others.
      Significant number (P<0.05) of patients (64.15%) required mechanical ventilation 
      and ionotropic support (79.24%). Mortality increased with increasing number of
      organ system involvement and reaching up to 100% with involvement of 5 or more
      organ systems. CONCLUSIONS: ICU care is the best form of treatment for terminally
      ill but resources should be used optimally so that a young deserving patient
      should not be sacrificed for the scarcity of resources.
FAU - Bajwa, Sukhminder Jit Singh
AU  - Bajwa SJ
AD  - Department of Anaesthesiology and Intensive Care, Gian Sagar Medical College &
      Hospital, Ram Nagar, Banur, Punjab, India.
FAU - Bajwa, Sukhwinder Kaur
AU  - Bajwa SK
FAU - Kaur, Jasbir
AU  - Kaur J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Indian J Palliat Care
JT  - Indian journal of palliative care
JID - 101261221
PMC - PMC3144437
OTO - NOTNLM
OT  - Cancer
OT  - Intensive care
OT  - Mechanical ventilation
OT  - Respiratory failure
OT  - Terminally ill
EDAT- 2010/05/01 00:00
MHDA- 2010/05/01 00:01
CRDT- 2011/08/04 06:00
PHST- 2011/08/04 06:00 [entrez]
PHST- 2010/05/01 00:00 [pubmed]
PHST- 2010/05/01 00:01 [medline]
AID - 10.4103/0973-1075.68406 [doi]
AID - IJPC-16-83 [pii]
PST - ppublish
SO  - Indian J Palliat Care. 2010 May;16(2):83-9. doi: 10.4103/0973-1075.68406.


PMID- 21811350
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1998-3735 (Electronic)
IS  - 0973-1075 (Linking)
VI  - 16
IP  - 2
DP  - 2010 May
TI  - Ethics and medico legal aspects of "not for resuscitation".
PG  - 66-9
LID - 10.4103/0973-1075.68404 [doi]
AB  - Not for resuscitation in India still remains an abstract concept with no clear
      guidelines or legal frame work. Cardiopulmonary resuscitation is a complex
      medical intervention which is often used inappropriately in hospitalized patients
      and usually guided by medical decision making rather than patient-directed
      choices. Patient autonomy still remains a weak concept and relatives are expected
      to make this big decision in a short time and at a time of great emotional
      distress. This article outlines concepts around ethics and medico legal aspects
      of not for resuscitation, especially in Indian setting.
FAU - Salins, Naveen Sulakshan
AU  - Salins NS
AD  - Palliative Medicine Consultant, Palliative Medicine Unit, Departments of
      Radiotherapy and Oncology, Shiridi SaiBaba Cancer Hospital and Research Centre,
      KMC Manipal, Manipal University 576104, India.
FAU - Pai, Sachin Gopalakrishna
AU  - Pai SG
FAU - Vidyasagar, Ms
AU  - Vidyasagar M
FAU - Sobhana, Manikkath
AU  - Sobhana M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Indian J Palliat Care
JT  - Indian journal of palliative care
JID - 101261221
PMC - PMC3144433
OTO - NOTNLM
OT  - Autonomy
OT  - Cardiopulmonary resuscitation
OT  - Ethics
OT  - Law
EDAT- 2010/05/01 00:00
MHDA- 2010/05/01 00:01
CRDT- 2011/08/04 06:00
PHST- 2011/08/04 06:00 [entrez]
PHST- 2010/05/01 00:00 [pubmed]
PHST- 2010/05/01 00:01 [medline]
AID - 10.4103/0973-1075.68404 [doi]
AID - IJPC-16-66 [pii]
PST - ppublish
SO  - Indian J Palliat Care. 2010 May;16(2):66-9. doi: 10.4103/0973-1075.68404.


PMID- 20428707
OWN - NLM
STAT- MEDLINE
DCOM- 20100628
LR  - 20190608
IS  - 0104-1169 (Print)
IS  - 0104-1169 (Linking)
VI  - 18
IP  - 1
DP  - 2010 Jan-Feb
TI  - Clinical reasoning and critical thinking.
PG  - 124-9
LID - S0104-11692010000100019 [pii]
AB  - This study identifies and analyzes nursing literature on clinical reasoning and
      critical thinking. A bibliographical search was performed in LILACS, SCIELO,
      PUBMED and CINAHL databases, followed by selection of abstracts and the reading
      of full texts. Through the review we verified that clinical reasoning develops
      from scientific and professional knowledge, is permeated by ethical decisions and
      nurses values and also that there are different personal and institutional
      strategies that might improve the critical thinking and clinical reasoning of
      nurses. Further research and evaluation of educational programs on clinical
      reasoning that integrate psychosocial responses to physiological responses of
      people cared by nurses is needed.
FAU - da Silva Bastos Cerullo, Josinete Aparecida
AU  - da Silva Bastos Cerullo JA
AD  - Escola de Enfermagem, Universidade de Sao Paulo, SP, Brazil. josinet@usp.br
FAU - de Almeida Lopes Monteiro da Cruz, Dina
AU  - de Almeida Lopes Monteiro da Cruz D
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - Rev Lat Am Enfermagem
JT  - Revista latino-americana de enfermagem
JID - 9420934
MH  - *Electronic Data Processing
MH  - Humans
MH  - Models, Theoretical
MH  - *Nursing Diagnosis
MH  - *Nursing Process
MH  - *Thinking
EDAT- 2010/04/30 06:00
MHDA- 2010/06/29 06:00
CRDT- 2010/04/30 06:00
PHST- 2009/03/27 00:00 [received]
PHST- 2009/07/28 00:00 [accepted]
PHST- 2010/04/30 06:00 [entrez]
PHST- 2010/04/30 06:00 [pubmed]
PHST- 2010/06/29 06:00 [medline]
AID - S0104-11692010000100019 [pii]
AID - 10.1590/s0104-11692010000100019 [doi]
PST - ppublish
SO  - Rev Lat Am Enfermagem. 2010 Jan-Feb;18(1):124-9. doi:
      10.1590/s0104-11692010000100019.


PMID- 20427818
OWN - NLM
STAT- MEDLINE
DCOM- 20100922
LR  - 20211203
IS  - 1946-6242 (Electronic)
IS  - 1946-6234 (Linking)
VI  - 2
IP  - 29
DP  - 2010 Apr 28
TI  - Six questions about translational due diligence.
PG  - 29cm14
LID - 10.1126/scitranslmed.3000985 [doi]
AB  - To maintain stable respect and support, translational research must be guided by 
      appropriate ethical, social, legal, and political concerns and carry out
      culturally competent practices. Considering six key questions concerning due
      diligence will enable the translational research community to examine critically 
      how it approaches these endeavors.
FAU - Selinger, Evan
AU  - Selinger E
AD  - Department of Philosophy, Rochester Institute of Technology, Rochester, NY 14623,
      USA. evan.selinger@rit.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Sci Transl Med
JT  - Science translational medicine
JID - 101505086
SB  - IM
MH  - Communication
MH  - Humans
MH  - Social Sciences
MH  - Technology Transfer
MH  - *Translational Research, Biomedical/standards
EDAT- 2010/04/30 06:00
MHDA- 2010/09/24 06:00
CRDT- 2010/04/30 06:00
PHST- 2010/04/30 06:00 [entrez]
PHST- 2010/04/30 06:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
AID - 2/29/29cm14 [pii]
AID - 10.1126/scitranslmed.3000985 [doi]
PST - ppublish
SO  - Sci Transl Med. 2010 Apr 28;2(29):29cm14. doi: 10.1126/scitranslmed.3000985.


PMID- 20427307
OWN - NLM
STAT- MEDLINE
DCOM- 20110406
LR  - 20211020
IS  - 1475-3901 (Electronic)
IS  - 1475-3898 (Linking)
VI  - 19
IP  - 6
DP  - 2010 Dec
TI  - Acute care practices relevant to quality end-of-life care: a survey of
      Pennsylvania hospitals.
PG  - e12
LID - 10.1136/qshc.2008.030056 [doi]
AB  - BACKGROUND: Improving end-of-life care in the hospital is a national priority.
      PURPOSE: To explore the prevalence and reasons for implementation of
      hospital-wide and intensive care unit (ICU) practices relevant to quality care in
      key end-of-life care domains and to discern major structural determinants of
      practice implementation. DESIGN: Cross-sectional mixed-mode survey of chief
      nursing officers of Pennsylvania acute care hospitals. RESULTS: The response rate
      was 74% (129 of 174). The prevalence of hospital and ICU practices ranged from
      95% for a hospital-wide formal code policy to 6% for regularly scheduled family
      meetings with an attending physician in the ICU. Most practices had less than 50%
      implementation; most were implemented primarily for quality improvement or to
      keep up with the standard of care. In a multivariable model including hospital
      structural characteristics, only hospital size independently predicted the
      presence of one or more hospital initiatives (ethics consult service, OR 6.13,
      adjusted p = 0.02; private conference room in the ICU for family meetings, OR
      4.54, adjusted p<0.001). CONCLUSIONS: There is low penetration of hospital
      practices relevant to quality end-of-life care in Pennsylvania acute care
      hospitals. Our results may serve to inform the development of future benchmark
      goals. It is critical to establish a strong evidence base for the practices most 
      associated with improved end-of-life care outcomes and to develop quality
      measures for end-of-life care to complement existing hospital quality measures
      that primarily focus on life extension.
FAU - Lin, C Y
AU  - Lin CY
AD  - Center for Research on Health Care and the Institute for Clinical Research
      Education, University of Pittsburgh School of Medicine, 200 Meyran Avenue, Suite 
      200, Pittsburgh, PA 15213, USA.
FAU - Arnold, R M
AU  - Arnold RM
FAU - Lave, J R
AU  - Lave JR
FAU - Angus, D C
AU  - Angus DC
FAU - Barnato, A E
AU  - Barnato AE
LA  - eng
GR  - K08 AG021921/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100427
PL  - England
TA  - Qual Saf Health Care
JT  - Quality & safety in health care
JID - 101136980
MH  - Cross-Sectional Studies
MH  - Health Care Surveys
MH  - Hospitals/*statistics & numerical data
MH  - Humans
MH  - Intensive Care Units/statistics & numerical data
MH  - Pennsylvania
MH  - Quality of Health Care
MH  - *Quality of Life
MH  - *Terminal Care
PMC - PMC4070305
MID - NIHMS538830
EDAT- 2010/04/30 06:00
MHDA- 2011/04/07 06:00
CRDT- 2010/04/30 06:00
PHST- 2010/04/30 06:00 [entrez]
PHST- 2010/04/30 06:00 [pubmed]
PHST- 2011/04/07 06:00 [medline]
AID - qshc.2008.030056 [pii]
AID - 10.1136/qshc.2008.030056 [doi]
PST - ppublish
SO  - Qual Saf Health Care. 2010 Dec;19(6):e12. doi: 10.1136/qshc.2008.030056. Epub
      2010 Apr 27.


PMID- 20393310
OWN - NLM
STAT- MEDLINE
DCOM- 20100719
LR  - 20220210
IS  - 1530-0366 (Electronic)
IS  - 1098-3600 (Linking)
VI  - 12
IP  - 4 Suppl
DP  - 2010 Apr
TI  - Myriad Genetics: In the eye of the policy storm.
PG  - S39-70
LID - 10.1097/GIM.0b013e3181d72661 [doi]
AB  - From the late 1980s, a storm surrounding the wisdom, ethics, and economics of
      human gene patents has been brewing. The various winds of concern in this storm
      touched on the impact of gene patents on basic and clinical research, on health
      care delivery, and on the ability of public health care systems to provide equal 
      access when faced with costly patented genetic diagnostic tests. Myriad Genetics,
      Inc., along with its subsidiary, Myriad Genetic Laboratories, Inc., a small
      Utah-based biotechnology company, found itself unwittingly in the eye of this
      storm after a series of decisions it made regarding the commercialization of a
      hereditary breast cancer diagnostic test. This case study examine the background 
      to Myriad's decisions, the context in which these decisions were made and the
      policy, research and business response to them.
FAU - Gold, E Richard
AU  - Gold ER
AD  - McGill Faculty of Law, McGill University, 3644 Peel Street, Montreal, Quebec,
      Canada. richard.gold2@mcgill.ca
FAU - Carbone, Julia
AU  - Carbone J
LA  - eng
GR  - P50 HG003391/HG/NHGRI NIH HHS/United States
GR  - P50 HG003391-050001/HG/NHGRI NIH HHS/United States
GR  - CAPMC/ CIHR/Canada
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Genet Med
JT  - Genetics in medicine : official journal of the American College of Medical
      Genetics
JID - 9815831
RN  - 0 (Reagent Kits, Diagnostic)
SB  - IM
CIN - Genet Med. 2010 Jul;12(7):471; author reply 471-2. PMID: 20631548
MH  - Biotechnology
MH  - Breast Neoplasms/diagnosis/*genetics
MH  - Commerce/economics/ethics
MH  - Female
MH  - Genes
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genetic Testing/*ethics
MH  - *Genetics
MH  - Health Policy
MH  - Health Services Accessibility/economics/*ethics
MH  - Humans
MH  - *Laboratories
MH  - Patents as Topic/*ethics
MH  - Reagent Kits, Diagnostic
MH  - Utah
PMC - PMC3037261
MID - NIHMS203462
EDAT- 2010/04/30 06:00
MHDA- 2010/07/20 06:00
CRDT- 2010/04/16 06:00
PHST- 2010/04/16 06:00 [entrez]
PHST- 2010/04/30 06:00 [pubmed]
PHST- 2010/07/20 06:00 [medline]
AID - 10.1097/GIM.0b013e3181d72661 [doi]
AID - S1098-3600(21)01996-1 [pii]
PST - ppublish
SO  - Genet Med. 2010 Apr;12(4 Suppl):S39-70. doi: 10.1097/GIM.0b013e3181d72661.


PMID- 22371755
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1896-9151 (Electronic)
IS  - 1734-1922 (Linking)
VI  - 6
IP  - 2
DP  - 2010 Apr 30
TI  - Characteristics of obstetric fistulas and the need for a prognostic
      classification system.
PG  - 253-6
LID - 10.5114/aoms.2010.13904 [doi]
AB  - INTRODUCTION: To evaluate the need for a prognostic classification system for
      obstetric fistula (OF) with the data obtained by a voluntarily action for OF
      repair in a regional hospital and Niger, Africa. MATERIAL AND METHODS: Obstetric 
      fistula (OF) characteristics of 51 women with vesicovaginal fistula in a fistula 
      campaign in Maradi Regional Hospital, Niger were evaluated. Initial basic
      gynecological examination, methylene blue (MBT) test and direct cystoscopy were
      used to describe the characteristics of the lesions. Demographic and clinical
      data were compared with the existing literature. RESULTS: In 31 (60%) cases were 
      the sizes of the fistula greater than 4 cm. The urethra was circumferentially
      lost in 8 (15.7%) women. In 18 (35.3%) women the trigone was involved. Extensive 
      fibrosis was present in 10 (19.6%) patients. Only in 11 (21.6%) patients without 
      any obliterating scarring, neither the trigone nor urethra were damaged. Five
      (9.8%) patients had severe infection. Five (9.8%) had multiple lesions.
      Thirty-four (66.6%) had a history of at least one previous attempt for fistula
      repair. A significant proportion of women were divorced or abandoned from their
      husband, and socially isolated. CONCLUSIONS: A simple, reproducible and
      universally accepted scientific classification or staging system for OF dealing
      with outcomes rather than anatomic landmarks should replace the present proposed 
      classification systems for prognostic and ethical purposes.
FAU - Karateke, Ates
AU  - Karateke A
AD  - Department of Pelvic Reconstructive Surgery, Zeynep Kamil Maternity Hospital,
      Istanbul, Turkey.
FAU - Cam, Cetin
AU  - Cam C
FAU - Ozdemir, Arman
AU  - Ozdemir A
FAU - Guney, Buhara
AU  - Guney B
FAU - Vatansever, Dogan
AU  - Vatansever D
FAU - Celik, Cem
AU  - Celik C
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - Arch Med Sci
JT  - Archives of medical science : AMS
JID - 101258257
PMC - PMC3281348
OTO - NOTNLM
OT  - classification system
OT  - obstetric fistula
OT  - surgical outcome
EDAT- 2010/04/30 00:00
MHDA- 2010/04/30 00:01
CRDT- 2012/02/29 06:00
PHST- 2009/01/05 00:00 [received]
PHST- 2009/02/15 00:00 [revised]
PHST- 2009/03/24 00:00 [accepted]
PHST- 2012/02/29 06:00 [entrez]
PHST- 2010/04/30 00:00 [pubmed]
PHST- 2010/04/30 00:01 [medline]
AID - 10.5114/aoms.2010.13904 [doi]
AID - 14656 [pii]
PST - ppublish
SO  - Arch Med Sci. 2010 Apr 30;6(2):253-6. doi: 10.5114/aoms.2010.13904.


PMID- 20425830
OWN - NLM
STAT- MEDLINE
DCOM- 20100812
LR  - 20211020
IS  - 1552-4833 (Electronic)
IS  - 1552-4825 (Linking)
VI  - 152A
IP  - 5
DP  - 2010 May
TI  - Consent for genetic research in the Framingham Heart Study.
PG  - 1250-6
LID - 10.1002/ajmg.a.33377 [doi]
AB  - Extensive efforts have been aimed at understanding the genetic underpinnings of
      complex diseases that affect humans. Numerous genome-wide association studies
      have assessed the association of genes with human disease, including the
      Framingham Heart Study (FHS), which genotyped 550,000 SNPs in 9,000 participants.
      The success of such efforts requires high rates of consent by participants, which
      is dependent on ethical oversight, communications, and trust between research
      participants and investigators. To study this we calculated percentages of
      participants who consented to collection of DNA and to various uses of their
      genetic information in two FHS cohorts between 2002 and 2009. The data included
      rates of consent for providing a DNA sample, creating an immortalized cell line, 
      conducting research on various genetic conditions including those that might be
      considered sensitive, and for notifying participants of clinically significant
      genetic findings were above 95%. Only with regard to granting permission to share
      DNA or genetic findings with for-profit companies was the consent rate below 95%.
      We concluded that the FHS has maintained high rates of retention and consent for 
      genetic research that has provided the scientific freedom to establish
      collaborations and address a broad range of research questions. We speculate that
      our high rates of consent have been achieved by establishing frequent and open
      communications with participants that highlight extensive oversight procedures.
      Our approach to maintaining high consent rates via ethical oversight of genetic
      research and communication with study participants is summarized in this report
      and should be of help to other studies engaged in similar types of research.
      Published 2010 Wiley-Liss, Inc.
FAU - Levy, Daniel
AU  - Levy D
AD  - Center for Population Studies, National Heart, Lung, and Blood Institute,
      Bethesda, MA 01702, USA. levyd@nih.gov
FAU - Splansky, Greta Lee
AU  - Splansky GL
FAU - Strand, Nicolle K
AU  - Strand NK
FAU - Atwood, Larry D
AU  - Atwood LD
FAU - Benjamin, Emelia J
AU  - Benjamin EJ
FAU - Blease, Susan
AU  - Blease S
FAU - Cupples, L Adrienne
AU  - Cupples LA
FAU - D'Agostino, Ralph B Sr
AU  - D'Agostino RB Sr
FAU - Fox, Caroline S
AU  - Fox CS
FAU - Kelly-Hayes, Margaret
AU  - Kelly-Hayes M
FAU - Koski, Greg
AU  - Koski G
FAU - Larson, Martin G
AU  - Larson MG
FAU - Mutalik, Karen M
AU  - Mutalik KM
FAU - Oberacker, Elizabeth
AU  - Oberacker E
FAU - O'Donnell, Christopher J
AU  - O'Donnell CJ
FAU - Sutherland, Patrice
AU  - Sutherland P
FAU - Valentino, Maureen
AU  - Valentino M
FAU - Vasan, Ramachandran S
AU  - Vasan RS
FAU - Wolf, Philip A
AU  - Wolf PA
FAU - Murabito, Joanne M
AU  - Murabito JM
LA  - eng
GR  - N01 HC025195/HC/NHLBI NIH HHS/United States
GR  - N01HC25195/HL/NHLBI NIH HHS/United States
GR  - N01-HC-25195/HC/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Am J Med Genet A
JT  - American journal of medical genetics. Part A
JID - 101235741
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Cohort Studies
MH  - DNA/analysis/genetics
MH  - *Genetic Research
MH  - *Heart
MH  - Humans
MH  - Informed Consent/*statistics & numerical data
MH  - Massachusetts
MH  - Patient Participation
MH  - Patient Preference
PMC - PMC2923558
MID - NIHMS205319
EDAT- 2010/04/29 06:00
MHDA- 2010/08/13 06:00
CRDT- 2010/04/29 06:00
PHST- 2010/04/29 06:00 [entrez]
PHST- 2010/04/29 06:00 [pubmed]
PHST- 2010/08/13 06:00 [medline]
AID - 10.1002/ajmg.a.33377 [doi]
PST - ppublish
SO  - Am J Med Genet A. 2010 May;152A(5):1250-6. doi: 10.1002/ajmg.a.33377.


PMID- 20425200
OWN - NLM
STAT- MEDLINE
DCOM- 20100721
LR  - 20211020
IS  - 1534-3081 (Electronic)
IS  - 1534-3081 (Linking)
VI  - 14
IP  - 2
DP  - 2010 Apr
TI  - Strategies for the prevention and management of neonatal and infant pain.
PG  - 113-23
LID - 10.1007/s11916-009-0091-0 [doi]
AB  - Health care professionals caring for neonates (birth to 28 days of life) and
      infants up to 1 year of age have a professional and ethical responsibility to
      provide safe and effective pain management during painful procedures. Despite 14 
      years of research reports highlighting that sick infants are exposed to large
      numbers of painful procedures with minimal or no provision of pain management
      strategies, and generation of abundant evidence to support effectiveness of pain 
      reduction strategies, insufficient practice changes have been made. As untreated 
      pain in infancy has both immediate and longer-term negative consequences, such as
      increased sensitivity and responses to subsequent pain, it is imperative that
      widespread sustained practice changes are made to reduce the burden of pain. This
      review highlights recent advances within the past 2 to 3 years in pain management
      of acute procedural pain for neonates and infants, proposes recommendations for
      future research, and addresses practical implications and challenges for
      implementing best pain management practices.
FAU - Harrison, Denise
AU  - Harrison D
AD  - Centre for Nursing and the Child Health Evaluative Sciences, Research Institute, 
      Hospital for Sick Children, Toronto, University of Toronto, Canada.
      denise.harrison@utoronto.ca
FAU - Yamada, Janet
AU  - Yamada J
FAU - Stevens, Bonnie
AU  - Stevens B
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Pain Headache Rep
JT  - Current pain and headache reports
JID - 100970666
RN  - 0 (Analgesics)
RN  - 57-50-1 (Sucrose)
SB  - IM
MH  - Analgesics/*therapeutic use
MH  - *Evidence-Based Medicine
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Neonatology
MH  - Pain/*drug therapy/*prevention & control
MH  - Pediatrics
MH  - Sucrose/*therapeutic use
RF  - 74
EDAT- 2010/04/29 06:00
MHDA- 2010/07/22 06:00
CRDT- 2010/04/29 06:00
PHST- 2010/04/29 06:00 [entrez]
PHST- 2010/04/29 06:00 [pubmed]
PHST- 2010/07/22 06:00 [medline]
AID - 10.1007/s11916-009-0091-0 [doi]
PST - ppublish
SO  - Curr Pain Headache Rep. 2010 Apr;14(2):113-23. doi: 10.1007/s11916-009-0091-0.


PMID- 20424275
OWN - NLM
STAT- MEDLINE
DCOM- 20100818
LR  - 20161021
IS  - 1758-1044 (Electronic)
IS  - 0951-4848 (Linking)
VI  - 23
IP  - 2
DP  - 2010 May
TI  - Ethical budgets: a critical success factor in implementing new public management 
      accountability in health care.
PG  - 76-83
LID - 10.1258/hsmr.2009.009024 [doi]
AB  - New public management accountability is increasingly being introduced into
      health-care systems throughout the world - albeit with mixed success. This paper 
      examines the successful introduction of new management accounting systems among
      general practitioners (GPs) as an aspect of reform in the Italian health-care
      system. In particular, the study examines the critical role played by the novel
      concept of an 'ethical budget' in engaging the willing cooperation of the medical
      profession in implementing change. Utilizing a qualitative research design, with 
      in-depth interviews with GPs, hospital doctors and managers, along with archival 
      analysis, the present study finds that management accounting can be successfully 
      implemented among medical professionals provided there is alignment between the
      management imperative and the ethical framework in which doctors practise their
      profession. The concept of an 'ethical budget' has been shown to be an innovative
      and effective tool in achieving this alignment.
FAU - Bosa, Iris M
AU  - Bosa IM
AD  - Business School, University of Edinburgh, Edinburgh, UK. Iris.Bosa@ed.ac.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - Health Serv Manage Res
JT  - Health services management research
JID - 8811549
MH  - Budgets/*ethics
MH  - Delivery of Health Care/*economics/organization & administration
MH  - Humans
MH  - Interviews as Topic
MH  - Italy
MH  - Physicians, Family
MH  - *Social Responsibility
EDAT- 2010/04/29 06:00
MHDA- 2010/08/19 06:00
CRDT- 2010/04/29 06:00
PHST- 2010/04/29 06:00 [entrez]
PHST- 2010/04/29 06:00 [pubmed]
PHST- 2010/08/19 06:00 [medline]
AID - 23/2/76 [pii]
AID - 10.1258/hsmr.2009.009024 [doi]
PST - ppublish
SO  - Health Serv Manage Res. 2010 May;23(2):76-83. doi: 10.1258/hsmr.2009.009024.


PMID- 20424254
OWN - NLM
STAT- MEDLINE
DCOM- 20100428
LR  - 20220311
IS  - 1538-3598 (Electronic)
IS  - 0098-7484 (Linking)
VI  - 303
IP  - 16
DP  - 2010 Apr 28
TI  - The older adult driver with cognitive impairment: "It's a very frustrating life".
PG  - 1632-41
LID - 10.1001/jama.2010.481 [doi]
AB  - Although automobiles remain the transportation of choice for many older adults,
      late-life cognitive impairment and dementia often impair the ability to drive
      safely. However, there is no commonly used method of assessing dementia severity 
      in relation to driving, no consensus on the assessment of older drivers with
      cognitive impairment, and no gold standard for determining driving fitness. Yet
      clinicians are called on by patients, their families, other health professionals,
      and often their state's Department of Motor Vehicles to assess their patients'
      fitness to drive and to make recommendations about driving privileges. This
      article describes the challenges of driving with cognitive impairment for both
      the patient and caregiver, summarizes the literature on dementia and driving,
      discusses evidence-based assessment of fitness to drive, and addresses important 
      ethical and legal issues. It also describes the role of physician assessment,
      referral for neuropsychological testing, screening for functional ability, tools 
      to assess dementia severity, driving evaluation clinics, and Department of Motor 
      Vehicles referrals that may assist with evaluation. Lastly, it discusses mobility
      counseling (eg, exploration of transportation alternatives), because health
      professionals need to address this important issue for older adults who lose the 
      ability to drive. The application of a comprehensive, interdisciplinary approach 
      to the older driver with cognitive impairment will have the best opportunity to
      enhance patients' social connectedness and quality of life while meeting their
      psychological and medical needs and maintaining personal and public safety.
FAU - Carr, David B
AU  - Carr DB
AD  - Department of Medicine, Washington University in St Louis, and The Rehabilitation
      Institute of St Louis, St Louis, Missouri 63017, USA. dcarr@im.wustl.edu
FAU - Ott, Brian R
AU  - Ott BR
LA  - eng
GR  - R01 AG016335/AG/NIA NIH HHS/United States
GR  - P01AG03991/AG/NIA NIH HHS/United States
GR  - AG16335/AG/NIA NIH HHS/United States
GR  - R01 AG016335-09/AG/NIA NIH HHS/United States
GR  - P50AG05681/AG/NIA NIH HHS/United States
GR  - P01 AG003991-28/AG/NIA NIH HHS/United States
GR  - P50 AG005681-28/AG/NIA NIH HHS/United States
GR  - P01 AG003991/AG/NIA NIH HHS/United States
GR  - P50 AG005681/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - JAMA
JT  - JAMA
JID - 7501160
SB  - IM
CIN - JAMA. 2010 Aug 18;304(7):744; author reply 744-5. PMID: 20716736
EIN - JAMA. 2010 Jun 16;303(23):2357
MH  - Accidents, Traffic
MH  - Activities of Daily Living
MH  - Aged
MH  - Aged, 80 and over
MH  - *Automobile Driving
MH  - Cognition Disorders/classification/*physiopathology
MH  - Counseling
MH  - Dementia/classification/*physiopathology
MH  - Eligibility Determination
MH  - Female
MH  - Humans
MH  - *Licensure
MH  - Male
MH  - Psychometrics
MH  - *Quality of Life
PMC - PMC2915446
MID - NIHMS209116
EDAT- 2010/04/29 06:00
MHDA- 2010/04/29 06:01
CRDT- 2010/04/29 06:00
PHST- 2010/04/29 06:00 [entrez]
PHST- 2010/04/29 06:00 [pubmed]
PHST- 2010/04/29 06:01 [medline]
AID - 303/16/1632 [pii]
AID - 10.1001/jama.2010.481 [doi]
PST - ppublish
SO  - JAMA. 2010 Apr 28;303(16):1632-41. doi: 10.1001/jama.2010.481.


PMID- 20424089
OWN - NLM
STAT- MEDLINE
DCOM- 20100915
LR  - 20141120
IS  - 1467-9280 (Electronic)
IS  - 0956-7976 (Linking)
VI  - 21
IP  - 4
DP  - 2010 Apr
TI  - Do green products make us better people?
PG  - 494-8
LID - 10.1177/0956797610363538 [doi]
AB  - Consumer choices reflect not only price and quality preferences but also social
      and moral values, as witnessed in the remarkable growth of the global market for 
      organic and environmentally friendly products. Building on recent research on
      behavioral priming and moral regulation, we found that mere exposure to green
      products and the purchase of such products lead to markedly different behavioral 
      consequences. In line with the halo associated with green consumerism, results
      showed that people act more altruistically after mere exposure to green products 
      than after mere exposure to conventional products. However, people act less
      altruistically and are more likely to cheat and steal after purchasing green
      products than after purchasing conventional products. Together, our studies show 
      that consumption is connected to social and ethical behaviors more broadly across
      domains than previously thought.
FAU - Mazar, Nina
AU  - Mazar N
AD  - University of Toronto, Joseph L. Rotman School of Management, Toronto, Ontario,
      Canada. nina.mazar@rotman.utoronto.ca
FAU - Zhong, Chen-Bo
AU  - Zhong CB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100305
PL  - United States
TA  - Psychol Sci
JT  - Psychological science
JID - 9007542
SB  - IM
MH  - Altruism
MH  - *Choice Behavior
MH  - *Conservation of Natural Resources
MH  - *Consumer Behavior
MH  - Deception
MH  - Environmental Restoration and Remediation/*ethics
MH  - Female
MH  - Humans
MH  - Interpersonal Relations
MH  - Male
MH  - *Moral Obligations
MH  - *Social Behavior
MH  - Social Desirability
MH  - Social Responsibility
MH  - Social Values
MH  - Theft
EDAT- 2010/04/29 06:00
MHDA- 2010/09/16 06:00
CRDT- 2010/04/29 06:00
PHST- 2010/04/29 06:00 [entrez]
PHST- 2010/04/29 06:00 [pubmed]
PHST- 2010/09/16 06:00 [medline]
AID - 0956797610363538 [pii]
AID - 10.1177/0956797610363538 [doi]
PST - ppublish
SO  - Psychol Sci. 2010 Apr;21(4):494-8. doi: 10.1177/0956797610363538. Epub 2010 Mar
      5.


PMID- 20424009
OWN - NLM
STAT- MEDLINE
DCOM- 20101130
LR  - 20100817
IS  - 1557-1246 (Electronic)
IS  - 1087-0547 (Linking)
VI  - 14
IP  - 2
DP  - 2010 Sep
TI  - Assessment of ADHD documentation from candidates requesting Americans With
      Disabilities Act (ADA) accommodations for the National Board of Osteopathic
      Medical Examiners COMLEX exam.
PG  - 104-8
LID - 10.1177/1087054710365056 [doi]
AB  - PURPOSE: Every year increasing numbers of candidates request special
      accommodations for high-stakes medical licensing examinations, due to ADHD, on
      the basis of the Americans with Disabilities Act (ADA). This poses significant
      challenges for both the applicant and the medical boards and has significant
      financial, legal, and ethical implications. The purpose of this survey is to
      review all applications requesting ADA accommodations, on the basis of ADHD,
      submitted to the National Board of Osteopathic Medical Examiners (NBOME) COMLEX
      exam. METHOD: The authors review all 50 requests for special accommodations, on
      the basis of ADHD, submitted to the NBOME between 2005 and 2007. All requests are
      reviewed by the investigators independently and then cross-checked to determine
      interrater reliability. RESULTS: Of all applicants, only 14% (7/50) provide
      sufficient documentation to support a diagnosis of ADHD. Interrater reliability
      is high. CONCLUSIONS: The majority of applicants who request special testing
      accommodations on the basis of ADHD do not provide adequate documentation to the 
      medical boards to support the diagnosis.
FAU - Joy, Javed A
AU  - Joy JA
AD  - Temple University School of Medicine, Philadelphia, PA, USA.
FAU - Julius, Rose J
AU  - Julius RJ
FAU - Akter, Rashida
AU  - Akter R
FAU - Baron, David A
AU  - Baron DA
LA  - eng
PT  - Journal Article
DEP - 20100427
PL  - United States
TA  - J Atten Disord
JT  - Journal of attention disorders
JID - 9615686
SB  - IM
MH  - *Attention Deficit Disorder with Hyperactivity
MH  - Disabled Persons/*legislation & jurisprudence
MH  - *Educational Measurement
MH  - Humans
MH  - Licensure, Medical/*legislation & jurisprudence
MH  - Osteopathic Medicine/*education
MH  - United States
EDAT- 2010/04/29 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/04/29 06:00
PHST- 2010/04/29 06:00 [entrez]
PHST- 2010/04/29 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 1087054710365056 [pii]
AID - 10.1177/1087054710365056 [doi]
PST - ppublish
SO  - J Atten Disord. 2010 Sep;14(2):104-8. doi: 10.1177/1087054710365056. Epub 2010
      Apr 27.


PMID- 20423533
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1756-994X (Electronic)
IS  - 1756-994X (Linking)
VI  - 2
IP  - 4
DP  - 2010 Apr 27
TI  - The public health utility of genome-wide association study results for smoking
      behavior.
PG  - 26
LID - 10.1186/gm147 [doi]
AB  - New approaches to improve smoking cessation rates are needed. In recent years,
      substantial progress has been made in understanding the genetics of smoking
      behavior, and this knowledge may eventually be used to personalize treatment for 
      smokers. Although there are highly significant and reproducible genetic
      associations, none are yet ready for clinical applications. We suggest that
      translational research from several disciplines, including behavioral science,
      ethics and economics, should be performed in parallel with ongoing genome-wide
      association studies for smoking behavior and pharmacogenetic trials. The
      coordinated effort of multidisciplinary research teams will help reveal the
      circumstances under which we can translate genetic insights into clinical
      practice in the hope of reducing the burden of smoking in society.
FAU - Furberg, Helena
AU  - Furberg H
AD  - Department of Psychiatry and Behavioral Science, Memorial Sloan Kettering Cancer 
      Center, 641 Lexington Ave, New York, NY 10022, USA. FurbergA@mskcc.org.
FAU - Ostroff, Jamie
AU  - Ostroff J
FAU - Lerman, Caryn
AU  - Lerman C
FAU - Sullivan, Patrick F
AU  - Sullivan PF
LA  - eng
GR  - K07 CA118412/CA/NCI NIH HHS/United States
PT  - Editorial
DEP - 20100427
PL  - England
TA  - Genome Med
JT  - Genome medicine
JID - 101475844
PMC - PMC2873804
EDAT- 2010/04/29 06:00
MHDA- 2010/04/29 06:01
CRDT- 2010/04/29 06:00
PHST- 2010/04/29 06:00 [entrez]
PHST- 2010/04/29 06:00 [pubmed]
PHST- 2010/04/29 06:01 [medline]
AID - gm147 [pii]
AID - 10.1186/gm147 [doi]
PST - epublish
SO  - Genome Med. 2010 Apr 27;2(4):26. doi: 10.1186/gm147.


PMID- 20423516
OWN - NLM
STAT- MEDLINE
DCOM- 20100614
LR  - 20211020
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 11
DP  - 2010 Apr 27
TI  - Understanding of research: a Sri Lankan perspective.
PG  - 7
LID - 10.1186/1472-6939-11-7 [doi]
AB  - BACKGROUND: Lack of proper understanding on the part of researchers about public 
      understanding of research and informed consent will increase the potential for
      malpractice. As a part of a larger study on ethics and informed consent in Sri
      Lanka, this study aimed to ascertain the level of understanding of 'research' by 
      exploring the views of the public and professionals. METHODS: Convenience
      sampling and snow ball technique were used for recruitment with an emphasis on
      balanced age and gender representation, diverse educational, socio-cultural and
      professional backgrounds, and previous research experience, either as researchers
      or participants. Content analysis of the data was carried out. RESULTS: 66
      persons (37 males, 29 females) participated. Although fundamentally a qualitative
      study, themes were also quantitatively analysed for informative results. Most
      participants thought that the word 'research' meant searching, looking, inquiring
      while some others thought it meant gathering information, gaining knowledge and
      learning.A third of participants did not offer an alternative word for research. 
      Others suggested the words survey, exploration, search, experiment, discovery,
      invention and study as being synonymous. Doctors, health professionals, health
      institutions, scientists, professionals, businessmen, pharmaceutical companies,
      students, teachers were identified as people who conduct research.Participants
      indicated that crucial information on deciding to participate in research
      included objectives of the research, project importance and relevance, potential 
      benefits to individuals and society, credibility & legitimacy of researchers,
      what is expected of participant, reason for selection, expected outcome,
      confidentiality and ability to withdraw at any time. A majority (89%) expressed
      their willingness to participate in future research. CONCLUSIONS: The results
      show that with or without prior experience in research, participants in this
      study had a reasonable understanding of research. The findings show that a
      decision about taking part in research is dependent on knowledge, education and
      also on social networks.The results demonstrate that the majority were supportive
      of health research and believe that research is beneficial to the welfare of
      society.
FAU - Sumathipala, Athula
AU  - Sumathipala A
AD  - Institute for Research & Development, Colombo, Sri Lanka.
      athula.sumthipala@kcl.ac.uk
FAU - Siribaddana, Sisira
AU  - Siribaddana S
FAU - Hewage, Suwin
AU  - Hewage S
FAU - Lekamwattage, Manura
AU  - Lekamwattage M
FAU - Athukorale, Manjula
AU  - Athukorale M
FAU - Siriwardhana, Chesmal
AU  - Siriwardhana C
FAU - Munasinghe, Kumudu
AU  - Munasinghe K
FAU - Sumathipala, Kethakie
AU  - Sumathipala K
FAU - Murray, Joanna
AU  - Murray J
FAU - Prince, Martin
AU  - Prince M
LA  - eng
GR  - 074928/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100427
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Biomedical Research/ethics
MH  - *Comprehension
MH  - Developing Countries
MH  - Ethics, Research
MH  - Female
MH  - Humans
MH  - *Informed Consent/ethics
MH  - Male
MH  - Middle Aged
MH  - Patient Selection/*ethics
MH  - Qualitative Research
MH  - Research Design
MH  - *Research Personnel/ethics
MH  - Sampling Studies
MH  - Sri Lanka
PMC - PMC2874563
EDAT- 2010/04/29 06:00
MHDA- 2010/06/15 06:00
CRDT- 2010/04/29 06:00
PHST- 2009/06/23 00:00 [received]
PHST- 2010/04/27 00:00 [accepted]
PHST- 2010/04/29 06:00 [entrez]
PHST- 2010/04/29 06:00 [pubmed]
PHST- 2010/06/15 06:00 [medline]
AID - 1472-6939-11-7 [pii]
AID - 10.1186/1472-6939-11-7 [doi]
PST - epublish
SO  - BMC Med Ethics. 2010 Apr 27;11:7. doi: 10.1186/1472-6939-11-7.


PMID- 20423360
OWN - NLM
STAT- MEDLINE
DCOM- 20100804
LR  - 20181201
IS  - 1365-2648 (Electronic)
IS  - 0309-2402 (Linking)
VI  - 66
IP  - 4
DP  - 2010 Apr
TI  - Genetic testing for cancer predisposition and implications for nursing practice: 
      narrative review.
PG  - 710-37
LID - 10.1111/j.1365-2648.2010.05286.x [doi]
AB  - AIM: This paper is a report of a review of literature on the psychological and
      social implications of genetic testing for cancer predisposition and how recent
      developments in knowledge about genetics may affect clinical practice.
      BACKGROUND: Knowledge about the genetics of disease has grown since the
      completion of the Human Genome Project. Many common genetic changes that
      predispose to cancer have been found. Identifying genetically 'at risk'
      individuals is going to become a feature of healthcare and nursing practice over 
      the next decade. The psychological and social effects of this knowledge on
      patients and their families are important considerations. DATA SOURCES: A search 
      of the British Nursing Index, CINAHL, EMBASE and PUBMED databases was conducted
      between June 2007 and December 2008 without date limits. Grey literature was
      sought using search engines and through searching relevant websites. REVIEW
      METHODS: A narrative review of studies published in English was conducted. The
      studies were reviewed for relevance and inclusion criteria; their methodological 
      quality was not evaluated. RESULTS: Seventy-eight papers met the inclusion
      criteria and fell into three thematic categories: social impact, psychological
      impact and interest in and uptake of genetic testing. To date, research has
      focussed on high-risk cancer genes. CONCLUSION: Genetic testing raises social,
      ethical and psychological concerns. Further research is required to determine how
      healthcare professionals can support the integration of genetics into clinical
      practice. Nurses will become increasingly involved in genetic testing and will
      play a key role in providing information, support and follow-up for individuals
      identified as being at higher risk.
FAU - Bancroft, Elizabeth Kathryn
AU  - Bancroft EK
AD  - Royal Marsden NHS Foundation Trust & Institute of Cancer Research, Sutton,
      Surrey, UK. elizabeth.bancroft@rmh.nhs.uk
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Adv Nurs
JT  - Journal of advanced nursing
JID - 7609811
SB  - IM
MH  - Attitude to Health
MH  - Genetic Counseling/psychology
MH  - Genetic Predisposition to Disease
MH  - Genetic Testing/*psychology/statistics & numerical data
MH  - Humans
MH  - Neoplasms/*genetics
MH  - *Nursing Process
RF  - 102
EDAT- 2010/04/29 06:00
MHDA- 2010/08/05 06:00
CRDT- 2010/04/29 06:00
PHST- 2010/04/29 06:00 [entrez]
PHST- 2010/04/29 06:00 [pubmed]
PHST- 2010/08/05 06:00 [medline]
AID - JAN5286 [pii]
AID - 10.1111/j.1365-2648.2010.05286.x [doi]
PST - ppublish
SO  - J Adv Nurs. 2010 Apr;66(4):710-37. doi: 10.1111/j.1365-2648.2010.05286.x.


PMID- 20423246
OWN - NLM
STAT- MEDLINE
DCOM- 20100803
LR  - 20100428
IS  - 1466-187X (Electronic)
IS  - 0142-159X (Linking)
VI  - 32
IP  - 5
DP  - 2010
TI  - Using medical drama to teach biomedical ethics to medical students.
PG  - e205-10
LID - 10.3109/01421591003697457 [doi]
AB  - Nowadays, clinicians are faced with multifaceted ethical concerns, and it is
      often argued that students of medicine should be well trained in clinical ethics 
      and have a minimum level of ethical sensitivity and critical analysis.
      Consequently, most medical colleges have introduced programs in biomedical
      ethics. It is often pointed out that there is a gap separating ethical theories
      from concrete moral dilemmas. This problem became less pervasive as case-studies 
      started being used. Nevertheless, vignettes are mostly presented as an addendum
      to a unit and often engage the students only "temporarily." It is my contention
      that this can be remedied if students were given a venue that will allow them to 
      appreciate as many particulars of the situation as possible, to engage in the
      case not merely as inactive spectators, rather to get entangled in the case just 
      enough to be involved yet remain sufficiently detached to be able to exercise
      critical analysis. This is possible through medical drama which, I will argue, is
      a narrative genre that enhances emotional engagement, cognitive development, and 
      moral imagination allowing for a more ethically sensitive student in training. To
      do that, reference will be made to the medical drama "House MD."
FAU - Arawi, Thalia
AU  - Arawi T
AD  - American University of Beirut, Internal Medicine, Beirut, Lebanon.
      ta16@aub.edu.lb
LA  - eng
PT  - Journal Article
PL  - England
TA  - Med Teach
JT  - Medical teacher
JID - 7909593
SB  - IM
MH  - *Drama
MH  - Ethics, Medical/*education
MH  - Humans
MH  - Physician-Patient Relations/ethics
MH  - *Students, Medical
MH  - Teaching/methods
EDAT- 2010/04/29 06:00
MHDA- 2010/08/04 06:00
CRDT- 2010/04/29 06:00
PHST- 2010/04/29 06:00 [entrez]
PHST- 2010/04/29 06:00 [pubmed]
PHST- 2010/08/04 06:00 [medline]
AID - 10.3109/01421591003697457 [doi]
PST - ppublish
SO  - Med Teach. 2010;32(5):e205-10. doi: 10.3109/01421591003697457.


PMID- 20423219
OWN - NLM
STAT- MEDLINE
DCOM- 20100930
LR  - 20161125
IS  - 1557-7708 (Electronic)
IS  - 1075-5535 (Linking)
VI  - 16
IP  - 4
DP  - 2010 Apr
TI  - Discrepancy between clinical course and drug-induced lymphocyte stimulation tests
      in a case of saireito-induced liver injury accompanied by Sjogren syndrome.
PG  - 501-5
LID - 10.1089/acm.2009.0183 [doi]
AB  - BACKGROUND: Saireito consists of components of shosaikoto and goreisan. There are
      several reports of liver injury caused by shosaikoto and saireito, whereas cases 
      caused by goreisan are rarely seen. PATIENT: A 70-year-old woman suffered from
      sicca of the eyes and oral cavity that arose in 2003. In June 2004, we diagnosed 
      her as having Sjogren syndrome on the basis of Schirmer's test, salivary
      scintigraphy, presence of anti-SS-A/Ro antibody, and subjective symptoms.
      Although a muscarinic agonist was commenced, her sicca symptoms did not improve. 
      INTERVENTIONS: In February 2008, 7.5 g/day of shosaikoto extract granules (for
      ethical use, Tsumura & Co., Tokyo, Japan) was introduced. Her symptoms and
      laboratory data did not change. The next month, the treatment was replaced by 9.0
      g/day of saireito extract granules (for ethical use, Tsumura & Co., Tokyo,
      Japan). RESULTS: After 10 weeks, elevation of liver enzymes was observed. On
      suspicion of drug-induced liver injury (DILI), saireito was withdrawn, and the
      patient's liver enzymes returned to normal the next month. Drug-induced
      lymphocyte stimulation tests (DLSTs) for saireito, shosaikoto, and goreisan were 
      all positive. CONCLUSIONS: The clinical course suggested allergy to the goreisan 
      component of saireito. It is important to be aware of the limitation of DLST as a
      diagnostic tool for DILI, especially for herbal medicines.
FAU - Tsuda, Tokutaro
AU  - Tsuda T
AD  - Department of Oriental Medicine, Doctoral Program of Medical Science, Kitasato
      University Graduate School, Sagamihara, Kanagawa, Japan.
      tsuda-t@insti.kitasato-u.ac.jp
FAU - Yashiro, Shinobu
AU  - Yashiro S
FAU - Gamo, Yuji
AU  - Gamo Y
FAU - Watanabe, Koji
AU  - Watanabe K
FAU - Hoshino, Takayuki
AU  - Hoshino T
FAU - Oikawa, Tetsuro
AU  - Oikawa T
FAU - Hanawa, Toshihiko
AU  - Hanawa T
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Altern Complement Med
JT  - Journal of alternative and complementary medicine (New York, N.Y.)
JID - 9508124
RN  - 0 (Drugs, Chinese Herbal)
SB  - IM
MH  - Aged
MH  - Chemical and Drug Induced Liver Injury/*etiology
MH  - Drug Hypersensitivity/*complications
MH  - Drugs, Chinese Herbal/*adverse effects
MH  - Female
MH  - Humans
MH  - Liver/*drug effects/enzymology/immunology
MH  - Lymphocyte Activation
MH  - Phytotherapy/*adverse effects
MH  - Sjogren's Syndrome/*drug therapy/immunology
EDAT- 2010/04/29 06:00
MHDA- 2010/10/01 06:00
CRDT- 2010/04/29 06:00
PHST- 2010/04/29 06:00 [entrez]
PHST- 2010/04/29 06:00 [pubmed]
PHST- 2010/10/01 06:00 [medline]
AID - 10.1089/acm.2009.0183 [doi]
PST - ppublish
SO  - J Altern Complement Med. 2010 Apr;16(4):501-5. doi: 10.1089/acm.2009.0183.


PMID- 20423202
OWN - NLM
STAT- MEDLINE
DCOM- 20100715
LR  - 20220317
IS  - 1445-6354 (Electronic)
IS  - 1445-6354 (Linking)
VI  - 10
IP  - 2
DP  - 2010 Apr-Jun
TI  - "Latte rural": the tangible and intangible factors important in the choice of a
      rural practice by recent GP graduates.
PG  - 1316
AB  - INTRODUCTION: A large of amount of literature exists on the factors that
      influence the recruitment and retention of rural general practitioners (GPs) in
      Australia and other countries. The selection of a rural practice location is
      known to be influenced by professional, personal and family, community and
      economic factors. Most of this research has been undertaken on the either the
      baby boomer generation or their predecessors, and this is likely to have
      influenced the responses gained. Generation X and Y doctors are known to have a
      different perception regarding workload, lifestyle and the support required to
      practise. The aim of this study was to explore, from a Generation X perspective, 
      factors deemed important by general practice graduates in selecting a rural
      practice at completion of their training. The study also aimed to identify the
      process general practice graduates use to identify a potential rural practice,
      and when they commence this process. METHODS: Semi-structured interviews were
      held with 15 rural pathway general practice registrars in their final year of
      training with 2 regional training providers in South Australia. The interview
      topics included source of information on potential practices, their ideal rural
      practice and community, the process used to select a practice, and when they
      commenced this process. Phenomenological hermeneutic thematic analysis of
      interview transcripts was undertaken to identify themes and sub-themes. RESULTS: 
      For an ideal rural practice, registrars wished to work in a practice with a
      friendly atmosphere, good business structure, support from senior GPs and in
      close proximity to a hospital. They also wanted reasonable on-call arrangements, 
      the chance to develop further skills (such as anaesthetics or obstetrics) and the
      freedom to practise according to their interests. They also emphasised the
      importance of a good team and an ethical practice. In terms of community,
      registrars wanted a positive living place, access to amenities such as childcare,
      good schools and the opportunity of work for their spouses. They also appreciated
      attractions such as the beach, or green farmland. Word of mouth, referrals by
      colleagues and experience of a practice were the most common approaches to
      finding a suitable rural practice. The majority of the registrars commenced
      selection of a rural practice in their last 6 months of training. CONCLUSIONS:
      Many of the factors identified by the Generation X registrars were similar to
      those identified by the previous generation. However, they also identified
      factors such as a positive team environment and practice with good ethics as
      important. The results can be used to tailor the marketing of rural practices to 
      Generation X general practice registrars.
FAU - Laurence, Caroline O
AU  - Laurence CO
AD  - Discipline of General Practice, The University of Adelaide, Adelaide, South
      Australia, Australia. caroline.laurence@adelaide.edu.au
FAU - Williamson, Victoria
AU  - Williamson V
FAU - Sumner, Karen E
AU  - Sumner KE
FAU - Fleming, Jenny
AU  - Fleming J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100421
PL  - Australia
TA  - Rural Remote Health
JT  - Rural and remote health
JID - 101174860
SB  - IM
MH  - Adult
MH  - Australia
MH  - *Career Choice
MH  - Career Mobility
MH  - Education, Medical, Continuing/organization & administration
MH  - Female
MH  - Humans
MH  - Interviews as Topic
MH  - Job Satisfaction
MH  - Male
MH  - Middle Aged
MH  - Personnel Selection/organization & administration
MH  - Physicians, Family/*psychology
MH  - Rural Health Services/*organization & administration
MH  - Workload
EDAT- 2010/04/29 06:00
MHDA- 2010/07/16 06:00
CRDT- 2010/04/29 06:00
PHST- 2010/04/29 06:00 [entrez]
PHST- 2010/04/29 06:00 [pubmed]
PHST- 2010/07/16 06:00 [medline]
AID - 1316 [pii]
PST - ppublish
SO  - Rural Remote Health. 2010 Apr-Jun;10(2):1316. Epub 2010 Apr 21.


PMID- 20422967
OWN - NLM
STAT- MEDLINE
DCOM- 20110323
LR  - 20211020
IS  - 0929-0273 (Print)
IS  - 0929-0273 (Linking)
VI  - 17
IP  - 1
DP  - 2010 Mar
TI  - Adding value? EU governance of organ donation and transplantation.
PG  - 51-79
AB  - This article examines recent developments in EU governance of organ donation and 
      transplantation, focusing on an analysis of the Commission's action plan and the 
      proposed Directive. While the aims of the plan are laudable, a number of concerns
      remain with respect to the timetable for the plan and the adoption of the
      Directive, as well as the management of ethical and risk issues. In the final
      analysis, the added value of EU governance initiatives in the field is likely to 
      be measured by the extent to which they successfully address the ongoing problem 
      of organ shortage in Member States.
FAU - Farrell, Anne-Maree
AU  - Farrell AM
AD  - School of Law, University of Manchester, UK.
LA  - eng
GR  - 087439/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur J Health Law
JT  - European journal of health law
JID - 9431861
SB  - IM
MH  - Codes of Ethics
MH  - European Union
MH  - Government Regulation
MH  - Health Education
MH  - *Health Policy
MH  - Humans
MH  - International Cooperation/*legislation & jurisprudence
MH  - Organ Transplantation/ethics/*legislation & jurisprudence
MH  - Patient Care
MH  - Patient Rights
MH  - Safety/legislation & jurisprudence
MH  - Tissue and Organ Procurement/ethics/*legislation & jurisprudence
EDAT- 2010/04/29 06:00
MHDA- 2011/03/24 06:00
CRDT- 2010/04/29 06:00
PHST- 2010/04/29 06:00 [entrez]
PHST- 2010/04/29 06:00 [pubmed]
PHST- 2011/03/24 06:00 [medline]
AID - 10.1163/157180909x12604572349683 [doi]
PST - ppublish
SO  - Eur J Health Law. 2010 Mar;17(1):51-79. doi: 10.1163/157180909x12604572349683.


PMID- 20422646
OWN - NLM
STAT- MEDLINE
DCOM- 20100721
LR  - 20151119
IS  - 1099-0798 (Electronic)
IS  - 0735-3936 (Linking)
VI  - 28
IP  - 2
DP  - 2010 Mar-Apr
TI  - Paraphilias with co-morbid psychopathy: the clinical and legal significance to
      sex offender assessments.
PG  - 211-23
LID - 10.1002/bsl.933 [doi]
AB  - This article briefly discusses the historical development of the constructs of
      paraphilia and psychopathy. An overview of recent developments in the assessment 
      of these constructs for legal purposes is also provided. The historical,
      clinical, legal, and ethical obligations of clinicians who work with persons
      suffering from paraphilias and co-morbid psychopathy is then reviewed. An
      emphasis of the current article is integrating recent developments in the
      construct of psychopathy into a discussion of sex offender risk assessment and
      treatment. The co-morbidity of psychopathy and paraphilias as factors in
      predicting risk of recidivism is reviewed. The need for practitioners to remain
      cognizant of language requirements in both legal and clinical contexts is
      addressed. Finally, this article reviews the legal history of sex offender
      legislation and its evolution into current United States Supreme Court
      jurisprudence.
FAU - Saleh, Fabian M
AU  - Saleh FM
AD  - Harvard Medical School, Law and Psychiatry Service, Massachusetts General
      Hospital, WACC-812, 15 Parkman Street, Boston, MA 02114, USA. fsaleh@partners.org
FAU - Malin, H Martin
AU  - Malin HM
FAU - Grudzinskas, Albert J Jr
AU  - Grudzinskas AJ Jr
FAU - Vitacco, Michael J
AU  - Vitacco MJ
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Behav Sci Law
JT  - Behavioral sciences & the law
JID - 8404861
SB  - IM
MH  - Antisocial Personality Disorder/*complications
MH  - Commitment of Mentally Ill/legislation & jurisprudence
MH  - Criminals
MH  - Humans
MH  - Paraphilic Disorders/*complications
MH  - Prisoners/legislation & jurisprudence
MH  - Sex Offenses/*legislation & jurisprudence
RF  - 64
EDAT- 2010/04/28 06:00
MHDA- 2010/07/22 06:00
CRDT- 2010/04/28 06:00
PHST- 2010/04/28 06:00 [entrez]
PHST- 2010/04/28 06:00 [pubmed]
PHST- 2010/07/22 06:00 [medline]
AID - 10.1002/bsl.933 [doi]
PST - ppublish
SO  - Behav Sci Law. 2010 Mar-Apr;28(2):211-23. doi: 10.1002/bsl.933.


PMID- 20422491
OWN - NLM
STAT- MEDLINE
DCOM- 20100715
LR  - 20100427
IS  - 1439-3522 (Electronic)
IS  - 0720-4299 (Linking)
VI  - 78
IP  - 5
DP  - 2010 May
TI  - [Ethical aspects of deep brain stimulation in the treatment of psychiatric
      disorders].
PG  - 269-78
LID - 10.1055/s-0029-1245208 [doi]
AB  - Deep brain stimulation (DBS) is currently being tested as a possible treatment
      for treatment-refractory psychiatric disorders. Besides the hope set on this new 
      therapeutic approach of DBS, there are at the same time doubts concerning the
      ethical acceptability in the treatment of individuals suffering from mental
      disorders. Taking the therapeutic benefit of DBS into account, the manuscript
      analyses ethical aspects of DBS application in psychiatry. In particular,
      possible effects on the patient's personality and self-determination are
      scrutinized. It is shown that personality changes may either occur as unintended 
      and potentially ethically troublesome side effects or may even be intended as
      legitimate therapy goals. The patient's self-determination may be both,
      endangered and supported by DBS. The ethical assessment of DBS considers
      therapeutic benefits, the method's minimal invasiveness and reversibility on the 
      one hand, as well as surgery-related risks of DBS treatment, an insufficient
      data-base due to currently missing long-term studies and the possibility of as
      yet inestimable, potentially long-term effects on the patient's personality and
      self-determination on the other hand. The ethical balancing arrives at the
      conclusion that DBS may be considered as ultima ratio in the treatment of
      psychiatric disorders and should preferably be combined with psychosocial
      measures. Furthermore, a prospective scientific evaluation of the procedure
      should include a systematic investigation of personality changes.
CI  - (c) Georg Thieme Verlag KG Stuttgart-New York.
FAU - Schmetz, M-K
AU  - Schmetz MK
AD  - ELSA-Nachwuchsforschergruppe Molekulare Medizin und medizinische Hirnforschung.
      Zum ethischen Profil molekularer Ansatze in der Humanmedizin und ihrer Anwendung 
      auf das menschliche Gehirn, Institut fur Wissenschaft und Ethik, Universitat
      Bonn, Bonner Talweg 57, Bonn. schmetz@iwe.uni-bonn.de
FAU - Heinemann, T
AU  - Heinemann T
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Ethische Aspekte der tiefen Hirnstimulation in der Therapie psychiatrischer
      Erkrankungen.
DEP - 20100426
PL  - Germany
TA  - Fortschr Neurol Psychiatr
JT  - Fortschritte der Neurologie-Psychiatrie
JID - 8103137
SB  - IM
MH  - Anxiety/psychology
MH  - Deep Brain Stimulation/adverse effects/*ethics
MH  - Humans
MH  - Mental Disorders/*therapy
MH  - Personality/physiology
MH  - Risk
RF  - 45
EDAT- 2010/04/28 06:00
MHDA- 2010/07/16 06:00
CRDT- 2010/04/28 06:00
PHST- 2010/04/28 06:00 [entrez]
PHST- 2010/04/28 06:00 [pubmed]
PHST- 2010/07/16 06:00 [medline]
AID - 10.1055/s-0029-1245208 [doi]
PST - ppublish
SO  - Fortschr Neurol Psychiatr. 2010 May;78(5):269-78. doi: 10.1055/s-0029-1245208.
      Epub 2010 Apr 26.


PMID- 20422452
OWN - NLM
STAT- MEDLINE
DCOM- 20101220
LR  - 20211020
IS  - 1572-8633 (Electronic)
IS  - 1386-7423 (Linking)
VI  - 13
IP  - 3
DP  - 2010 Aug
TI  - Medicine, human rights and ethics: paths to universal rights.
PG  - 247-9
LID - 10.1007/s11019-010-9244-5 [doi]
FAU - Frewer, Andreas
AU  - Frewer A
FAU - Rothhaar, Markus
AU  - Rothhaar M
LA  - eng
PT  - Editorial
PT  - Introductory Journal Article
PL  - Netherlands
TA  - Med Health Care Philos
JT  - Medicine, health care, and philosophy
JID - 9815900
SB  - IM
MH  - *Bioethics
MH  - *Ethics, Medical
MH  - *Global Health
MH  - *Human Rights
MH  - Humans
EDAT- 2010/04/28 06:00
MHDA- 2010/12/21 06:00
CRDT- 2010/04/28 06:00
PHST- 2010/04/28 06:00 [entrez]
PHST- 2010/04/28 06:00 [pubmed]
PHST- 2010/12/21 06:00 [medline]
AID - 10.1007/s11019-010-9244-5 [doi]
PST - ppublish
SO  - Med Health Care Philos. 2010 Aug;13(3):247-9. doi: 10.1007/s11019-010-9244-5.


PMID- 20422143
OWN - NLM
STAT- MEDLINE
DCOM- 20100820
LR  - 20211020
IS  - 1433-0458 (Electronic)
IS  - 0017-6192 (Linking)
VI  - 58
IP  - 5
DP  - 2010 May
TI  - [Optimizing interdisciplinary flow of information : development of a
      communication system for a cochlear implant center with out-patient
      rehabilitation].
PG  - 465-71
LID - 10.1007/s00106-010-2092-z [doi]
AB  - BACKGROUND: Due to the growing number of cochlear implant (CI) patients, a well
      organized system of patient data allowing swift access is required. Therefore, a 
      databank has been designed to achieve an effective interdisciplinary flow of
      information between diagnostics, therapy and rehabilitation. METHODS: The
      departments of audiology, CI fitting, speech and hearing rehabilitation,
      logopaedics and medical staff were requested to design forms containing relevant 
      data for the evaluation of diagnostic, therapeutic and rehabilitation outcome.
      Forms were optimized and finally adjusted to an Access database. Time management 
      and satisfaction of employees were evaluated by questionnaire. The local ethics
      committee authorized the project. RESULTS: To achieve optimal administration of
      CI patient data a working platform founded on an Access data base was designed.
      Patient data were available almost immediately after diagnosis and therapy to all
      other partners within the CI centre, leading to better time management in the
      planning of CI therapy and consequently improved rehabilitation. In addition,
      internal communication between the different disciplines improved significantly. 
      A number of data sheets are used to illustrate how the database functions.
      CONCLUSION: Using this database we were able to improve the flow of information
      in our CI centre, as well as significantly reduce the time required for
      administrative tasks such as letters to doctors, health insurances, schools.
      Finally, data are available for scientific and economic purposes, including their
      possible long-term integration in an electronic patient file.
FAU - Arweiler-Harbeck, D
AU  - Arweiler-Harbeck D
AD  - Klinik fur Hals-Nasen-Ohren-Heilkunde, Universitatsklinikum Duisburg-Essen,
      HNO-Universitatsklinik Essen, Hufelandstrasse 55, 45122, Essen, Deutschland.
      diana.arweiler-harbeck@uk-essen.de
FAU - Bagus, H
AU  - Bagus H
FAU - Ramm, B
AU  - Ramm B
FAU - Vogel, A
AU  - Vogel A
LA  - ger
PT  - Journal Article
TT  - Optimierung des interdisziplinaren Informationsflusses : Entwicklung eines
      Kommunikationssystems fur ein Cochlear-implant-Zentrum mit ambulanter
      Rehabilitation.
PL  - Germany
TA  - HNO
JT  - HNO
JID - 2985099R
SB  - IM
MH  - Cochlear Implantation/*statistics & numerical data
MH  - Cochlear Implants/*statistics & numerical data
MH  - Germany/epidemiology
MH  - Humans
MH  - *Interdisciplinary Communication
MH  - Outpatient Clinics, Hospital/*statistics & numerical data
MH  - Rehabilitation Centers/*statistics & numerical data
MH  - Vestibulocochlear Nerve Diseases/*surgery
MH  - *Workflow
EDAT- 2010/04/28 06:00
MHDA- 2010/08/21 06:00
CRDT- 2010/04/28 06:00
PHST- 2010/04/28 06:00 [entrez]
PHST- 2010/04/28 06:00 [pubmed]
PHST- 2010/08/21 06:00 [medline]
AID - 10.1007/s00106-010-2092-z [doi]
PST - ppublish
SO  - HNO. 2010 May;58(5):465-71. doi: 10.1007/s00106-010-2092-z.


PMID- 20421549
OWN - NLM
STAT- MEDLINE
DCOM- 20100512
LR  - 20100920
IS  - 1538-3679 (Electronic)
IS  - 0003-9926 (Linking)
VI  - 170
IP  - 8
DP  - 2010 Apr 26
TI  - Is emergency research without initial consent justified?: the consent substitute 
      model.
PG  - 668-74
LID - 10.1001/archinternmed.2010.80 [doi]
AB  - Emergency research poses a fundamental ethical dilemma: prohibit valuable
      research because informed consent is not possible or enroll individuals in
      clinical trials without informed consent. Although emergency research without
      initial consent is allowable in the United States, its regulatory status remains 
      uncertain internationally. More important, no ethical justification for emergency
      research without consent has been widely accepted. Whether emergency research
      without initial consent can be justified depends on whether the values that are
      secured by informed consent-respect for autonomy and protection of well-being-can
      be secured by other means. Analysis suggests that these values can be secured by 
      the satisfaction of 5 conditions: (1) responsiveness (the experimental
      intervention must be responsive to an urgent medical need of the patients), (2)
      comparable risk-benefit ratio (the risk-benefit ratio of the experimental
      intervention is favorable, and at least as favorable as that of available
      alternatives and the control, if any), (3) no conflicting preferences (there is
      no compelling reason to think that participation in the research conflicts with
      enrolled patients' values or interests), (4) minimal net risks (nonbeneficial
      procedures included in the study cumulatively pose no greater than minimal risk),
      and (5) prompt consent (consent for ongoing and additional emergency research
      interventions is obtained as soon as possible). Together, these conditions
      constitute an ethical substitute for informed consent in emergency
      research-forming the consent substitute model.
FAU - Largent, Emily A
AU  - Largent EA
AD  - National Institutes of Health, 10 Center Dr, Bldg 10, Room 1C118, Bethesda, MD
      20892-1156, USA.
FAU - Wendler, David
AU  - Wendler D
FAU - Emanuel, Ezekiel
AU  - Emanuel E
FAU - Miller, Franklin G
AU  - Miller FG
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Arch Intern Med
JT  - Archives of internal medicine
JID - 0372440
SB  - IM
CIN - Arch Intern Med. 2010 Sep 13;170(16):1508-9; author reply 1509. PMID: 20837844
MH  - Biomedical Research/*ethics/standards
MH  - Emergency Medicine/*ethics/standards
MH  - Humans
MH  - Informed Consent/*ethics/standards
MH  - Male
MH  - Models, Organizational
MH  - Needs Assessment
MH  - Patient Rights/*ethics
MH  - Patient Selection
MH  - *Professional Autonomy
MH  - United States
RF  - 41
EDAT- 2010/04/28 06:00
MHDA- 2010/05/13 06:00
CRDT- 2010/04/28 06:00
PHST- 2010/04/28 06:00 [entrez]
PHST- 2010/04/28 06:00 [pubmed]
PHST- 2010/05/13 06:00 [medline]
AID - 170/8/668 [pii]
AID - 10.1001/archinternmed.2010.80 [doi]
PST - ppublish
SO  - Arch Intern Med. 2010 Apr 26;170(8):668-74. doi: 10.1001/archinternmed.2010.80.


PMID- 20421086
OWN - NLM
STAT- MEDLINE
DCOM- 20100727
LR  - 20100427
IS  - 1878-7452 (Electronic)
IS  - 1878-7452 (Linking)
VI  - 67
IP  - 1
DP  - 2010 Jan-Feb
TI  - The eighty-hour workweek: surgical attendings' perspectives.
PG  - 25-31
LID - 10.1016/j.jsurg.2009.12.003 [doi]
AB  - OBJECTIVE: The year 2008 was a sentinel year in resident education; this was the 
      first graduating general surgery class trained entirely under the 80-hour
      workweek. The purpose of this study was to evaluate attending surgeon perceptions
      of surgical resident attitudes and performance before and after duty-hour
      restrictions. DESIGN: An electronic survey was sent to all surgical teaching
      institutions in North Carolina. Both surgeon and hospital characteristics were
      documented. The survey consisted of questions designed to assess residents'
      attitudes/performance before and after the implementation of the work-hour
      restriction. RESULTS: In all, 77 surveys were returned (33% response rate). The
      survey demonstrated that 92% of educators who responded to the survey recognized 
      a difference between the restricted residents (RRs) and the nonrestricted
      residents (NRRs), and most respondents (67%) attributed this to both the
      work-hour restrictions and the work ethic of current residents. Most attending
      surgeons reported no difference between the RRs and the NRRs in most categories; 
      however, they identified a negative change in the areas of work ethic, technical 
      skills development, decision-making/critical-thinking skills, and patient
      ownership among the RR group. Most surgeons expressed less trust (55%) with
      patient care and less confidence (68%) in residents' ability to operate
      independently in the RR group. Eighty-nine percent indicated that additional
      decreases in work hours would continue to hamper the mission of timely and
      comprehensive resident education. CONCLUSIONS: The perception of surgical
      educators was that RRs are clearly different from the NRRs and that the primary
      difference is in work ethic and duty-hour restrictions. Although similar in most 
      attributes, RRs are perceived as having a lower baseline work ethic and a less
      developed technical skill set, decision-making ability, and sense of patient
      ownership. Subsequent study is needed to evaluate these concerns.
CI  - Copyright 2010 Association of Program Directors in Surgery. Published by Elsevier
      Inc. All rights reserved.
FAU - Griner, Devan
AU  - Griner D
AD  - Department of Surgery, South East Area Health Education Center, New Hanover
      Regional Medical Center, Wilmington, North Carolina 28401, USA.
FAU - Menon, Rema P
AU  - Menon RP
FAU - Kotwall, Cyrus A
AU  - Kotwall CA
FAU - Clancy, Thomas V
AU  - Clancy TV
FAU - Hope, William W
AU  - Hope WW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Surg Educ
JT  - Journal of surgical education
JID - 101303204
SB  - IM
CIN - J Surg Educ. 2010 Jan-Feb;67(1):32. PMID: 20421087
MH  - Attitude of Health Personnel
MH  - *Clinical Competence
MH  - Decision Making
MH  - Ethics, Professional
MH  - General Surgery/*education
MH  - Hospitals, Teaching
MH  - Humans
MH  - Internship and Residency/*organization & administration
MH  - *Medical Staff, Hospital
MH  - North Carolina
MH  - Personnel Staffing and Scheduling/*standards
MH  - Physician-Patient Relations
MH  - Quality of Health Care
MH  - Work Schedule Tolerance
MH  - Workload
EDAT- 2010/04/28 06:00
MHDA- 2010/07/28 06:00
CRDT- 2010/04/28 06:00
PHST- 2009/09/08 00:00 [received]
PHST- 2009/11/16 00:00 [revised]
PHST- 2009/12/07 00:00 [accepted]
PHST- 2010/04/28 06:00 [entrez]
PHST- 2010/04/28 06:00 [pubmed]
PHST- 2010/07/28 06:00 [medline]
AID - S1931-7204(09)00224-4 [pii]
AID - 10.1016/j.jsurg.2009.12.003 [doi]
PST - ppublish
SO  - J Surg Educ. 2010 Jan-Feb;67(1):25-31. doi: 10.1016/j.jsurg.2009.12.003.


PMID- 20420791
OWN - NLM
STAT- MEDLINE
DCOM- 20100608
LR  - 20190608
IS  - 0946-1965 (Print)
IS  - 0946-1965 (Linking)
VI  - 48
IP  - 5
DP  - 2010 May
TI  - Relative bioavailability study with two oral formulations of topiramate using a
      validated UPLC-MS/MS method.
PG  - 342-8
AB  - Changes in bioavailability of anticonvulsant drugs such as topiramate may cause
      loss of or worsened seizure control. Thus, the purpose of this study was to
      evaluate, in a double-blind crossover design, the bioavailability between two
      oral formulations of topiramate in healthy volunteers after a single dose. The
      protocol, approved by the Institutional Committee of Ethics, consisted of
      administration of 1 tablet of 100 mg of topiramate of each formulation (Toprel
      and Topamax), to 20 healthy volunteers after a 12 h overnight fast, using an
      open, two-period, randomized, crossover and double-blind design. Thus, the plasma
      concentrations (Cp) of topiramate were measured at predetermined intervals of
      time, from 0 to 24 h, using a validated UPLC-MS/MS method. Based on plasma
      concentration-time profiles we obtained the following pharmacokinetic parameters:
      AUC(0-inf) 63,418.31 +/- 22,141.69 and 67,094.70 +/- 22,487.2 ngh/ml; AUC0-24:
      30,421.02 +/- 9,964.0 and 30,489.35 +/- 9,407.17, ng x h/ml; tmax: 2.77 +/- 1.76 
      and 1.95 +/- 1.89 h; C(max): 2,143.33 +/- 724.26 and 2,262.51 +/- 751.12 ng/ml,
      for A (Toprel) and B (Topamax), respectively. All these differences were not
      statically significant with 90% confidence interval. The test of bioequivalence
      showed that Cmax, AUC(0-24) and AUC(0-inf) parameters are found within the range 
      of 0.8 - 1.25 recommended by the FDA with a probability of bioequivalence of
      100%. In accordance with these results, we can conclude that Toprel 100 mg, A
      (Test), is a bioequivalent generic and interchangeable with Topamax 100 mg, B
      (Reference).
FAU - Saavedra, I
AU  - Saavedra I
AD  - Laboratory of Pharmacokinetics and Bioavailability, IFT, Molecular and Clinical
      Pharmacology Program, Biomedical Sciences Institute, Faculty of Medicine,
      University of Chile, Santiago, Chile.
FAU - Tamayo, E
AU  - Tamayo E
FAU - Gamboa, A
AU  - Gamboa A
FAU - Sasso, J
AU  - Sasso J
FAU - Varela, N
AU  - Varela N
FAU - Moreno, I
AU  - Moreno I
FAU - Marchant, D
AU  - Marchant D
FAU - Caceres, D
AU  - Caceres D
FAU - Quinones, L
AU  - Quinones L
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Germany
TA  - Int J Clin Pharmacol Ther
JT  - International journal of clinical pharmacology and therapeutics
JID - 9423309
RN  - 0 (Anticonvulsants)
RN  - 0 (Drugs, Generic)
RN  - 0 (Tablets)
RN  - 0H73WJJ391 (Topiramate)
RN  - 30237-26-4 (Fructose)
SB  - IM
MH  - Adult
MH  - Anticonvulsants/administration & dosage/*pharmacokinetics
MH  - Area Under Curve
MH  - Biological Availability
MH  - Chromatography, Liquid/*methods
MH  - Cross-Over Studies
MH  - Double-Blind Method
MH  - Drugs, Generic/administration & dosage/pharmacokinetics
MH  - Female
MH  - Fructose/administration & dosage/*analogs & derivatives/pharmacokinetics
MH  - Humans
MH  - Male
MH  - Tablets
MH  - Tandem Mass Spectrometry/*methods
MH  - Therapeutic Equivalency
MH  - Topiramate
MH  - Young Adult
EDAT- 2010/04/28 06:00
MHDA- 2010/06/09 06:00
CRDT- 2010/04/28 06:00
PHST- 2010/04/28 06:00 [entrez]
PHST- 2010/04/28 06:00 [pubmed]
PHST- 2010/06/09 06:00 [medline]
AID - 7529 [pii]
AID - 10.5414/cpp48342 [doi]
PST - ppublish
SO  - Int J Clin Pharmacol Ther. 2010 May;48(5):342-8. doi: 10.5414/cpp48342.


PMID- 20420637
OWN - NLM
STAT- MEDLINE
DCOM- 20100805
LR  - 20210423
IS  - 1600-6143 (Electronic)
IS  - 1600-6135 (Linking)
VI  - 10
IP  - 4
DP  - 2010 Apr
TI  - Transplantation and mental retardation: what is the meaning of a discrimination?
PG  - 727-730
LID - 10.1111/j.1600-6143.2010.03052.x [doi]
AB  - The issue of transplantation for patients affected by mental retardation (MR) has
      been and continues to be a matter of discussion. The recent policy of the Veneto 
      region, a highly populated area in northern Italy, indicates that patients with
      MR are not eligible for any transplant of solid organs, indicating intelligence
      quotient (IQ) <50 as absolute and IQ <70 as a relative exclusion criteria. In the
      present study, we review current conceptualizations of MR, along with the current
      knowledge on transplantation in this population. Finally, we will review the
      international guidelines on this matter and discuss the social, ethical and
      political significance of such policy, arguing that it discriminates persons
      affected by MR.
FAU - Panocchia, N
AU  - Panocchia N
AD  - Hemodialysis Service, Department of Surgery, Catholic University, Rome, Italy.
FAU - Bossola, M
AU  - Bossola M
AD  - Hemodialysis Service, Department of Surgery, Catholic University, Rome, Italy.
FAU - Vivanti, G
AU  - Vivanti G
AD  - Department of Psychiatry and Behavioral Sciences, University of California,
      Davis, CA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
SB  - IM
MH  - *Ethics, Medical
MH  - Health Policy
MH  - Humans
MH  - *Intellectual Disability
MH  - Intelligence
MH  - Italy
MH  - *Transplantation
EDAT- 2010/04/28 06:00
MHDA- 2010/08/06 06:00
CRDT- 2010/04/28 06:00
PHST- 2010/04/28 06:00 [entrez]
PHST- 2010/04/28 06:00 [pubmed]
PHST- 2010/08/06 06:00 [medline]
AID - 10.1111/j.1600-6143.2010.03052.x [doi]
PST - ppublish
SO  - Am J Transplant. 2010 Apr;10(4):727-730. doi: 10.1111/j.1600-6143.2010.03052.x.


PMID- 20420628
OWN - NLM
STAT- MEDLINE
DCOM- 20100721
LR  - 20100427
IS  - 1600-6143 (Electronic)
IS  - 1600-6135 (Linking)
VI  - 10
IP  - 5
DP  - 2010 May
TI  - Donor intervention and organ preservation: where is the science and what are the 
      obstacles?
PG  - 1155-62
LID - 10.1111/j.1600-6143.2010.03100.x [doi]
AB  - The organ shortage is widely acknowledged as the most critical factor hindering
      the full realization of success for solid organ transplantation. Innovation in
      the areas of donor management and organ preservation offers the most realistic
      hope to improve both the quality and size of the current organ supply. Although
      the basic science dissecting the complex processes of brain death and
      ischemia/reperfusion injury is replete with exciting discoveries, the clinical
      science investigating donor management and organ preservation is sparse in
      contrast. This review will survey the current landscape of trials to mitigate
      organ injury through interventions administered to donors in vivo or organs ex
      vivo. Consideration will then be given to the scientific, logistical and ethical 
      obstacles that impede the transformation of laboratory breakthroughs into
      innovative treatments that simultaneously improve organ quality and supply.
FAU - Feng, S
AU  - Feng S
AD  - University of California San Francisco, San Francisco, CA, USA.
      sandy.feng@ucsfmedctr.org
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
SB  - IM
MH  - Brain Death
MH  - Humans
MH  - Organ Preservation/*methods
MH  - Reperfusion Injury
MH  - Tissue Donors/supply & distribution
RF  - 38
EDAT- 2010/04/28 06:00
MHDA- 2010/07/22 06:00
CRDT- 2010/04/28 06:00
PHST- 2010/04/28 06:00 [entrez]
PHST- 2010/04/28 06:00 [pubmed]
PHST- 2010/07/22 06:00 [medline]
AID - AJT3100 [pii]
AID - 10.1111/j.1600-6143.2010.03100.x [doi]
PST - ppublish
SO  - Am J Transplant. 2010 May;10(5):1155-62. doi: 10.1111/j.1600-6143.2010.03100.x.


PMID- 20420356
OWN - NLM
STAT- MEDLINE
DCOM- 20100518
LR  - 20191027
IS  - 1754-9507 (Print)
IS  - 1754-9507 (Linking)
VI  - 12
IP  - 2
DP  - 2010 Apr
TI  - "You feel like family..." professional boundaries and social model aphasia
      groups.
PG  - 152-61
AB  - In this theoretical paper, we argue that the adoption of the social model to
      aphasia rehabilitation within group settings changes the metaphorical location of
      the boundaries between clinicians and clients. Despite a growing literature on
      group work for aphasia and social model applications for people with chronic
      aphasia, there has been almost no attention paid to how professional boundaries
      are negotiated. This paper reviews how this issue is dealt with within
      professional codes of ethics and what is written more broadly on professional
      boundaries, and then uses a number of real case examples to encourage further
      discussion and awareness of this important issue in aphasia rehabilitation within
      group settings.
FAU - Sherratt, Sue
AU  - Sherratt S
AD  - University of Newcastle, Callaghan, NSW 2308, Australia.
      sue.sherratt@newcastle.edu.au
FAU - Hersh, Deborah
AU  - Hersh D
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Speech Lang Pathol
JT  - International journal of speech-language pathology
JID - 101320232
SB  - IM
MH  - Aphasia/psychology/*rehabilitation
MH  - Attitude of Health Personnel
MH  - Awareness
MH  - Codes of Ethics
MH  - Conflict of Interest
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Models, Psychological
MH  - *Professional Competence
MH  - *Professional Role
MH  - *Professional-Patient Relations/ethics
MH  - *Psychotherapy, Group/ethics
MH  - *Social Behavior
MH  - Speech-Language Pathology/ethics/*methods
EDAT- 2010/04/28 06:00
MHDA- 2010/05/19 06:00
CRDT- 2010/04/28 06:00
PHST- 2010/04/28 06:00 [entrez]
PHST- 2010/04/28 06:00 [pubmed]
PHST- 2010/05/19 06:00 [medline]
AID - 10.3109/17549500903521806 [doi]
PST - ppublish
SO  - Int J Speech Lang Pathol. 2010 Apr;12(2):152-61. doi: 10.3109/17549500903521806.


PMID- 20420350
OWN - NLM
STAT- MEDLINE
DCOM- 20100518
LR  - 20191210
IS  - 1754-9507 (Print)
IS  - 1754-9507 (Linking)
VI  - 12
IP  - 2
DP  - 2010 Apr
TI  - The ICF and speech-language pathology: aspiring to a fuller realization of
      ethical and moral issues.
PG  - 87-93
AB  - The World Health Organization's (WHO) International Classification of
      Functioning, Disability, and Health (ICF) is a tool that was developed to improve
      the functional health of the world's people. The ICF is meant to be more than
      simply a better way to classify functional limitations. WHO seeks to change the
      way people view disability. This article discusses the ethical guidelines listed 
      in the ICF and how they can be used by speech-language pathologists to aspire to 
      a fuller realization of the ethical and moral aspects of their vocation. This
      realization includes an argument that the disability rights struggle is part of
      an overall quest for the basic human rights of all people.
FAU - Threats, Travis T
AU  - Threats TT
AD  - Department of Communication Sciences and Disorders, Saint Louis University, St.
      Louis, MI, USA. threatst@slu.edu
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Speech Lang Pathol
JT  - International journal of speech-language pathology
JID - 101320232
SB  - IM
MH  - Aspirations, Psychological
MH  - Attitude of Health Personnel
MH  - Confidentiality
MH  - *Disability Evaluation
MH  - Disabled Persons/*classification
MH  - Global Health
MH  - Health Knowledge, Attitudes, Practice
MH  - *Health Status Indicators
MH  - Human Rights
MH  - Humans
MH  - *Professional Competence
MH  - Professional Practice/*ethics
MH  - Public Opinion
MH  - Social Responsibility
MH  - Speech-Language Pathology/*ethics
MH  - *World Health Organization
EDAT- 2010/04/28 06:00
MHDA- 2010/05/19 06:00
CRDT- 2010/04/28 06:00
PHST- 2010/04/28 06:00 [entrez]
PHST- 2010/04/28 06:00 [pubmed]
PHST- 2010/05/19 06:00 [medline]
AID - 10.3109/17549500903568476 [doi]
PST - ppublish
SO  - Int J Speech Lang Pathol. 2010 Apr;12(2):87-93. doi: 10.3109/17549500903568476.


PMID- 27741793
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1354-5760 (Print)
IS  - 1354-5760 (Linking)
VI  - 17
IP  - 2
DP  - 2010 Apr 28
TI  - Medical Ethics and the Elderly Gurcharan S Rai Medical Ethics and the Elderly
      Radcliffe Publishing pound22.99 188pp 9781846193071 1846193079 [Formula: see
      text].
PG  - 11
AB  - THIS THIRD edition of Gurcharan Rai's book includes information on the Mental
      Capacity Act 2005 and its implementation, as well as updates on palliative care, 
      support for people with dementia and decisions to refuse treatment in advance.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Manag (Harrow)
JT  - Nursing management (Harrow, London, England : 1994)
JID - 9433248
EDAT- 2010/04/28 00:00
MHDA- 2010/04/28 00:01
CRDT- 2016/10/16 06:00
PHST- 2016/10/16 06:00 [entrez]
PHST- 2010/04/28 00:00 [pubmed]
PHST- 2010/04/28 00:01 [medline]
AID - 10.7748/nm.17.2.11.s15 [doi]
PST - ppublish
SO  - Nurs Manag (Harrow). 2010 Apr 28;17(2):11. doi: 10.7748/nm.17.2.11.s15.


PMID- 20419847
OWN - NLM
STAT- MEDLINE
DCOM- 20100729
LR  - 20211020
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Linking)
VI  - 16
IP  - 16
DP  - 2010 Apr 28
TI  - Acute pancreatitis in pregnancy: an unresolved issue.
PG  - 2065-6
AB  - Management of acute pancreatitis in pregnancy is based on expert opinion only,
      due to geographic and ethic variations. Nonbiliary causes should be sought as
      they are associated with worse outcomes. Alcohol as a cause of acute pancreatitis
      is not rare. Hemoconcentration as a marker of fluid deficit and severity should
      be predicted with caution and fluid resuscitation should be done carefully by
      closely monitoring the central venous pressure, cardiac and respiratory system.
      Hypercalcemia of hyperparathyroidism may be falsely lowered due to
      hypoalbuminemia or suppressed by magnesium tocolysis.
FAU - Jain, Pankaj
AU  - Jain P
LA  - eng
PT  - Comment
PT  - Letter
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
SB  - IM
CON - World J Gastroenterol. 2009 Dec 7;15(45):5641-6. PMID: 19960559
MH  - Acute Disease
MH  - Female
MH  - Humans
MH  - Hypercalcemia/complications/diagnosis
MH  - Hyperparathyroidism/complications/diagnosis
MH  - Pancreatitis/*diagnosis/*therapy
MH  - Pregnancy
MH  - Pregnancy Complications/*diagnosis
MH  - Tocolysis
MH  - Treatment Outcome
PMC - PMC2860087
EDAT- 2010/04/27 06:00
MHDA- 2010/07/30 06:00
CRDT- 2010/04/27 06:00
PHST- 2010/04/27 06:00 [entrez]
PHST- 2010/04/27 06:00 [pubmed]
PHST- 2010/07/30 06:00 [medline]
AID - 10.3748/wjg.v16.i16.2065 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2010 Apr 28;16(16):2065-6. doi: 10.3748/wjg.v16.i16.2065.


PMID- 20419473
OWN - NLM
STAT- MEDLINE
DCOM- 20101220
LR  - 20211020
IS  - 1572-8633 (Electronic)
IS  - 1386-7423 (Linking)
VI  - 13
IP  - 3
DP  - 2010 Aug
TI  - Documentation of torture and the Istanbul Protocol: applied medical ethics.
PG  - 279-86
LID - 10.1007/s11019-010-9248-1 [doi]
AB  - The so-called Istanbul Protocol, a Manual on the Effective Investigation and
      Documentation of Torture and other Cruel, Inhumane or Degrading Treatment or
      Punishment was adopted by the United Nations soon after its completion in 1999
      and since then has become an acknowledged standard for documenting cases of
      alleged torture and other forms of severe maltreatment. In 2009 the "Forum for
      medicine and human rights" at the Medical Faculty at the University
      Erlangen-Nuremburg has provided the first German edition of this manual. The
      article traces back the development of the protocol taking into account the
      general background as well as the factual occasion of its initiation. The main
      ethical and legal principles of the manual are introduced as well as the projects
      for implementing the rules provided in the protocol that have been carried out so
      far. From this the urgent need for implementation of the Istanbul Protocol
      guidelines also in Europe and in German-speaking countries and here not
      exclusively but especially within asylum procedures becomes clear.
FAU - Furtmayr, Holger
AU  - Furtmayr H
AD  - Institut fur Geschichte und Ethik der Medizin, Friedrich-Alexander-Universitat
      Erlangen-Nurnberg, Gluckstr. 10, 91054, Erlangen, Germany.
      holger.furtmayr@ethik.med.uni-erlangen.de
FAU - Frewer, Andreas
AU  - Frewer A
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Med Health Care Philos
JT  - Medicine, health care, and philosophy
JID - 9815900
SB  - IM
MH  - *Ethics, Medical
MH  - Human Rights/*legislation & jurisprudence
MH  - Human Rights Abuses/*legislation & jurisprudence
MH  - Humans
MH  - International Cooperation
MH  - Torture/*legislation & jurisprudence
MH  - United Nations
EDAT- 2010/04/27 06:00
MHDA- 2010/12/21 06:00
CRDT- 2010/04/27 06:00
PHST- 2010/04/27 06:00 [entrez]
PHST- 2010/04/27 06:00 [pubmed]
PHST- 2010/12/21 06:00 [medline]
AID - 10.1007/s11019-010-9248-1 [doi]
PST - ppublish
SO  - Med Health Care Philos. 2010 Aug;13(3):279-86. doi: 10.1007/s11019-010-9248-1.


PMID- 20418774
OWN - NLM
STAT- MEDLINE
DCOM- 20110316
LR  - 20211101
IS  - 1533-4112 (Electronic)
IS  - 1095-0680 (Linking)
VI  - 26
IP  - 4
DP  - 2010 Dec
TI  - The emerging role for repetitive transcranial magnetic stimulation in optimizing 
      the treatment of adolescent depression.
PG  - 323-9
LID - 10.1097/YCT.0b013e3181dd17eb [doi]
AB  - Major depressive disorder (MDD) in adolescents is a common illness and
      significant public health problem. Treatment is challenging because of
      recurrences and limited modalities. Selective serotonin reuptake inhibitors and
      cognitive behavioral therapy are considered the standard of care in severe or
      treatment-resistant MDD in this age group. However, responses to these
      interventions are often suboptimal. A growing body of research supports the
      efficacy of repetitive transcranial magnetic stimulation (rTMS) for the treatment
      of MDD in adults. Induced seizures are a primary safety concern, although this is
      rare with appropriate precautions. There is, however, limited experience with
      rTMS as a therapeutic intervention for adolescent psychiatric disturbances. This 
      review will summarize the rTMS efficacy and safety data in adults and describe
      all published experience with adolescent MDD. Applications in other adolescent
      psychiatric illnesses such as schizophrenia and attention-deficit/hyperactivity
      disorder are reviewed. Safety and ethical issues are paramount with
      investigational treatments in adolescent psychiatric illnesses. However, further 
      research with rTMS in adolescent MDD is imperative to establish standards for
      optimal stimulation site, treatment parameters, and its role in treatment
      algorithms. These may diverge from adult data. Early intervention with
      neuromodulation could also hold the promise of addressing the developmental
      course of dysfunctional neurocircuitry.
FAU - Croarkin, Paul E
AU  - Croarkin PE
AD  - Department of Psychiatry, University of Texas Southwestern Medical Center,
      Dallas, TX 75235, USA. Paul.Croarkin@utsouthwestern.edu
FAU - Wall, Christopher A
AU  - Wall CA
FAU - McClintock, Shawn M
AU  - McClintock SM
FAU - Kozel, Frank Andrew
AU  - Kozel FA
FAU - Husain, Mustafa M
AU  - Husain MM
FAU - Sampson, Shirlene M
AU  - Sampson SM
LA  - eng
GR  - K23 MH070897/MH/NIMH NIH HHS/United States
GR  - UL1RR024982/RR/NCRR NIH HHS/United States
GR  - 5 K23 MH070897-02/MH/NIMH NIH HHS/United States
GR  - K23 MH070897-04/MH/NIMH NIH HHS/United States
GR  - 5 UL1 RR024982-02/RR/NCRR NIH HHS/United States
GR  - UL1 RR024982/RR/NCRR NIH HHS/United States
GR  - UL1 RR024982-03/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
PL  - United States
TA  - J ECT
JT  - The journal of ECT
JID - 9808943
SB  - IM
MH  - Adolescent
MH  - *Adolescent Psychiatry/ethics
MH  - Adult
MH  - Child
MH  - Clinical Trials as Topic
MH  - Depressive Disorder, Major/psychology/*therapy
MH  - Humans
MH  - *Transcranial Magnetic Stimulation/adverse effects/ethics
PMC - PMC2933284
MID - NIHMS198963
EDAT- 2010/04/27 06:00
MHDA- 2011/03/17 06:00
CRDT- 2010/04/27 06:00
PHST- 2010/04/27 06:00 [entrez]
PHST- 2010/04/27 06:00 [pubmed]
PHST- 2011/03/17 06:00 [medline]
AID - 10.1097/YCT.0b013e3181dd17eb [doi]
PST - ppublish
SO  - J ECT. 2010 Dec;26(4):323-9. doi: 10.1097/YCT.0b013e3181dd17eb.


PMID- 20418491
OWN - NLM
STAT- MEDLINE
DCOM- 20100913
LR  - 20211020
IS  - 1549-5469 (Electronic)
IS  - 1088-9051 (Linking)
VI  - 20
IP  - 6
DP  - 2010 Jun
TI  - Ethical challenges in genotype-driven research recruitment.
PG  - 705-9
LID - 10.1101/gr.104455.109 [doi]
FAU - Beskow, Laura M
AU  - Beskow LM
AD  - Center for Genome Ethics, Law and Policy, Duke Institute for Genome Sciences and 
      Policy, Durham, North Carolina 27708, USA. laura.beskow@duke.edu
FAU - Linney, Kristen N
AU  - Linney KN
FAU - Radtke, Rodney A
AU  - Radtke RA
FAU - Heinzen, Erin L
AU  - Heinzen EL
FAU - Goldstein, David B
AU  - Goldstein DB
LA  - eng
GR  - RC1 HG005787/HG/NHGRI NIH HHS/United States
GR  - RC1HG005787/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100423
PL  - United States
TA  - Genome Res
JT  - Genome research
JID - 9518021
SB  - IM
MH  - Adult
MH  - *Biomedical Research
MH  - Child
MH  - Epilepsy/genetics
MH  - *Ethics
MH  - Genotype
MH  - Humans
MH  - *Patient Selection
PMC - PMC2877567
EDAT- 2010/04/27 06:00
MHDA- 2010/09/14 06:00
CRDT- 2010/04/27 06:00
PHST- 2010/04/27 06:00 [entrez]
PHST- 2010/04/27 06:00 [pubmed]
PHST- 2010/09/14 06:00 [medline]
AID - gr.104455.109 [pii]
AID - 10.1101/gr.104455.109 [doi]
PST - ppublish
SO  - Genome Res. 2010 Jun;20(6):705-9. doi: 10.1101/gr.104455.109. Epub 2010 Apr 23.


PMID- 20418165
OWN - NLM
STAT- MEDLINE
DCOM- 20101220
LR  - 20220318
IS  - 1472-6491 (Electronic)
IS  - 1472-6483 (Linking)
VI  - 20
IP  - 7
DP  - 2010 Jun
TI  - Family planning, fertility awareness and knowledge about Italian legislation on
      assisted reproduction among Italian academic students.
PG  - 873-9
LID - 10.1016/j.rbmo.2010.03.024 [doi]
AB  - Over the last century, most industrialized countries have experienced a
      progressive increase in maternal age at first pregnancy and a reduction of
      fertility rate, with important social and economic consequences. Moreover in
      Italy a very restrictive law on assisted reproductive technologies was introduced
      in 2004, limiting its effectiveness and causing a strong public debate that
      unfortunately focused more on the political and ethical implications of the law
      than on the medical and technical aspects of assisted reproduction. The present
      study performed an epidemiological investigation among the students of Turin
      University in the year 2006/07 in order to assess three aspects: the factors
      affecting the decision to become parents, their level of consciousness about
      human reproduction and their level of knowledge about the legal rules that
      regulate assisted reproduction in Italy. The study also wanted to clarify how the
      sex (male or female) and the type of education (sciences or humanities) could
      affect their opinions and knowledge in this area. It was observed that young
      people consider parenthood an important part of their life, but knowledge about
      human fertility and legal rules regulating assisted reproduction is rather poor, 
      regardless of sex and type of education.
CI  - Copyright 2010 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights
      reserved.
FAU - Rovei, Valentina
AU  - Rovei V
AD  - Reproductive Medicine and IVF Unit, Department of Obstetrical and Gynaecological 
      Sciences, University of Torino, St Anna Hospital, Torino, Italy.
FAU - Gennarelli, Gianluca
AU  - Gennarelli G
FAU - Lantieri, Teresa
AU  - Lantieri T
FAU - Casano, Simona
AU  - Casano S
FAU - Revelli, Alberto
AU  - Revelli A
FAU - Massobrio, Marco
AU  - Massobrio M
LA  - eng
PT  - Journal Article
DEP - 20100328
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
SB  - IM
MH  - Adult
MH  - *Family Planning Services
MH  - Female
MH  - *Fertility
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Italy
MH  - Male
MH  - Maternal Age
MH  - Pregnancy
MH  - Reproductive Techniques, Assisted/*legislation & jurisprudence
MH  - Universities
EDAT- 2010/04/27 06:00
MHDA- 2010/12/21 06:00
CRDT- 2010/04/27 06:00
PHST- 2009/09/01 00:00 [received]
PHST- 2010/01/04 00:00 [revised]
PHST- 2010/03/10 00:00 [accepted]
PHST- 2010/04/27 06:00 [entrez]
PHST- 2010/04/27 06:00 [pubmed]
PHST- 2010/12/21 06:00 [medline]
AID - S1472-6483(10)00175-6 [pii]
AID - 10.1016/j.rbmo.2010.03.024 [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2010 Jun;20(7):873-9. doi: 10.1016/j.rbmo.2010.03.024. Epub
      2010 Mar 28.


PMID- 20417697
OWN - NLM
STAT- MEDLINE
DCOM- 20100910
LR  - 20131121
IS  - 1879-3169 (Electronic)
IS  - 0378-4274 (Linking)
VI  - 198
IP  - 1
DP  - 2010 Sep 15
TI  - Cadmium in shellfish: the British Columbia, Canada experience--a mini-review.
PG  - 7-12
LID - 10.1016/j.toxlet.2010.04.012 [doi]
AB  - Over 10 years ago, research scientists in the federal department of Fisheries and
      Oceans Canada (DFO) were alerted to the presence of high levels of cadmium, a
      toxic metal, in the Pacific oyster (Crassostrea gigas) cultured in British
      Columbia (BC), Canada waters. This mini-review summarizes the most recent
      published studies on levels of cadmium in shellfish from the Pacific Northwest
      (BC and Washington State). Recent health risk assessments with respect to the
      ingestion of BC oysters are presented. The review concludes with a discussion on 
      the ethical dilemma now facing the shellfish industry in the Pacific Northwest
      and provides recommendations for the culturing of shellfish without fear of high 
      cadmium levels.
CI  - 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Bendell, L I
AU  - Bendell LI
AD  - Department of Biological Sciences, Simon Fraser University, Burnaby, BC, Canada. 
      bendell@sfu.ca
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100424
PL  - Netherlands
TA  - Toxicol Lett
JT  - Toxicology letters
JID - 7709027
RN  - 00BH33GNGH (Cadmium)
SB  - IM
MH  - Animals
MH  - Aquaculture
MH  - British Columbia
MH  - Cadmium/*metabolism
MH  - Crassostrea/*metabolism
MH  - Environmental Exposure/analysis/statistics & numerical data
MH  - Food Industry/standards
MH  - Humans
MH  - Quality Control
MH  - Shellfish/standards/*statistics & numerical data
RF  - 21
EDAT- 2010/04/27 06:00
MHDA- 2010/09/11 06:00
CRDT- 2010/04/27 06:00
PHST- 2010/03/03 00:00 [received]
PHST- 2010/04/09 00:00 [revised]
PHST- 2010/04/14 00:00 [accepted]
PHST- 2010/04/27 06:00 [entrez]
PHST- 2010/04/27 06:00 [pubmed]
PHST- 2010/09/11 06:00 [medline]
AID - S0378-4274(10)01454-2 [pii]
AID - 10.1016/j.toxlet.2010.04.012 [doi]
PST - ppublish
SO  - Toxicol Lett. 2010 Sep 15;198(1):7-12. doi: 10.1016/j.toxlet.2010.04.012. Epub
      2010 Apr 24.


PMID- 20417254
OWN - NLM
STAT- MEDLINE
DCOM- 20101103
LR  - 20211203
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1800
IP  - 9
DP  - 2010 Sep
TI  - Effective culture conditions for the induction of pluripotent stem cells.
PG  - 956-63
LID - 10.1016/j.bbagen.2010.04.004 [doi]
AB  - BACKGROUND: Induced pluripotent stem (iPS) cells, which are functionally
      comparable to embryonic stem (ES) cells, can be generated from mouse fibroblasts 
      by expression of a defined set of transcription factors Oct4, Sox2, Klf4, and
      c-Myc. Since iPS cells are generated from somatic cells, they provide an
      invaluable source of pluripotent stem cells for cell transplantation therapy that
      does not present ethical problems. However, the reprogramming efficiency is
      extremely low, and optimal culture conditions for iPS cell derivation have not
      been clearly defined. METHODS: To generate iPS cells efficiently, we tested 10
      different culture conditions: DMEM supplemented with 15% fetal bovine serum
      (FBS), Knockout DMEM with 15% FBS from Invitrogen, Equitech, or HyClone, DMEM
      with 15% Knockout Serum Replacement (KSR), and Knockout DMEM with 10%, 15%, 20%, 
      25%, or 35% KSR. These media all contain 2 mM L-glutamine, 100 muM nonessential
      amino acids, 100 muM beta-mercaptoethanol, 1000 units ml(-)(1) leukemia
      inhibitory factor (LIF), 50 units ml(-)(1) penicillin, and 50 mug ml(-)(1)
      streptomycin. RESULTS: Medium containing Knockout DMEM with 20% KSR permits
      efficient induction of iPS cells from both mouse embryonic fibroblasts (MEFs) and
      adult tail tip fibroblasts (TTFs). Mouse iPS cells generated in the condition
      express ES cell marker genes such as Oct4, Sox2, Rex1, and Nanog at levels
      comparable to those of ES cells. Furthermore, iPS cells derived form MEFs and
      adult TTFs can contribute to adult chimeras. CONCLUSION: Our iPS cell induction
      efficiency is greater than that described in other reports. GENERAL SIGNIFICANCE:
      These findings provide an important catalyst for examining different culture
      environments for the generation of iPS cells.
CI  - Copyright (c) 2010 Elsevier B.V. All rights reserved.
FAU - Okada, Minoru
AU  - Okada M
AD  - Biomolecular Networks Laboratories, Department of Frontier Biosciences, Graduate 
      School of Frontier Biosciences, Osaka University, Osaka, Japan.
FAU - Oka, Masahiro
AU  - Oka M
FAU - Yoneda, Yoshihiro
AU  - Yoneda Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100422
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
RN  - 0 (Antigens, Differentiation)
RN  - 0 (Klf4 protein, mouse)
RN  - 0 (Kruppel-Like Factor 4)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Antigens, Differentiation/genetics/*metabolism
MH  - Cattle
MH  - Cell Culture Techniques/*methods
MH  - Cells, Cultured
MH  - Embryonic Stem Cells/cytology/metabolism
MH  - Induced Pluripotent Stem Cells/*cytology/*metabolism
MH  - Kruppel-Like Factor 4
MH  - Mice
MH  - Transcription Factors/genetics/*metabolism
EDAT- 2010/04/27 06:00
MHDA- 2010/11/04 06:00
CRDT- 2010/04/27 06:00
PHST- 2009/12/24 00:00 [received]
PHST- 2010/04/12 00:00 [revised]
PHST- 2010/04/14 00:00 [accepted]
PHST- 2010/04/27 06:00 [entrez]
PHST- 2010/04/27 06:00 [pubmed]
PHST- 2010/11/04 06:00 [medline]
AID - S0304-4165(10)00111-X [pii]
AID - 10.1016/j.bbagen.2010.04.004 [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 2010 Sep;1800(9):956-63. doi: 10.1016/j.bbagen.2010.04.004.
      Epub 2010 Apr 22.


PMID- 20417131
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20100712
IS  - 1557-3117 (Electronic)
IS  - 1053-2498 (Linking)
VI  - 29
IP  - 7
DP  - 2010 Jul
TI  - Editor's response to "ethical issues associated with globalization of
      placebo-controlled trials in pulmonary arterial hypertension".
PG  - 827-8
LID - 10.1016/j.healun.2010.03.009 [doi]
FAU - Park, Myung H
AU  - Park MH
FAU - Rubin, Lewis J
AU  - Rubin LJ
LA  - eng
PT  - Comment
PT  - Letter
DEP - 20100422
PL  - United States
TA  - J Heart Lung Transplant
JT  - The Journal of heart and lung transplantation : the official publication of the
      International Society for Heart Transplantation
JID - 9102703
RN  - 0 (Placebos)
RN  - 0 (Vasodilator Agents)
SB  - IM
CON - J Heart Lung Transplant. 2010 Jul;29(7):825-6. PMID: 20456982
MH  - Controlled Clinical Trials as Topic/*ethics/*standards
MH  - Developed Countries
MH  - Humans
MH  - Hypertension, Pulmonary/*drug therapy
MH  - *Internationality
MH  - Placebos/*therapeutic use
MH  - Publishing/ethics/standards
MH  - Vasodilator Agents/*therapeutic use
EDAT- 2010/04/27 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/04/27 06:00
PHST- 2010/03/17 00:00 [received]
PHST- 2010/03/17 00:00 [accepted]
PHST- 2010/04/27 06:00 [entrez]
PHST- 2010/04/27 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - S1053-2498(10)00201-9 [pii]
AID - 10.1016/j.healun.2010.03.009 [doi]
PST - ppublish
SO  - J Heart Lung Transplant. 2010 Jul;29(7):827-8. doi: 10.1016/j.healun.2010.03.009.
      Epub 2010 Apr 22.


PMID- 20416454
OWN - NLM
STAT- MEDLINE
DCOM- 20100506
LR  - 20100426
IS  - 1097-6817 (Electronic)
IS  - 0194-5998 (Linking)
VI  - 142
IP  - 5
DP  - 2010 May
TI  - Pharyngeal packing is a predisposing factor for postoperative aphthous stomatitis
      in nasal surgery.
PG  - 672-6
LID - 10.1016/j.otohns.2009.12.040 [doi]
AB  - OBJECTIVE: To evaluate whether pharyngeal packing is a predisposing factor for
      the development of postoperative aphthous stomatitis in nasal surgery. STUDY
      DESIGN: A prospective, randomized, controlled trial. SETTING: A tertiary referral
      center. SUBJECTS AND METHODS: After the study was approved by the local ethics
      committee, 100 adult patients scheduled for routine nasal surgery were enrolled. 
      The development of postoperative aphthous lesions within three days after surgery
      was evaluated in patients in whom a pharyngeal pack was (Group 1) or was not
      (Group 2) applied during nasal surgery. RESULTS: In Group 1, the presence of
      pharyngeal pack increased the risk for postoperative oral mucosal aphthae
      development by 4.64 times (P = 0.02, RR = 4.64, 95% CI = 1.22-17.91). No
      significant associations were found between postoperative oral mucosal aphthae
      development and sex (P = 1), age (P = 0.69), height (P = 0.73), weight (P =
      0.22), or duration of surgery (P = 0.47) in Group 1. CONCLUSION: Pharyngeal
      packing during nasal surgery increases postoperative morbidity by leading to the 
      development of painful oral aphthous lesions.
CI  - Copyright 2010 American Academy of Otolaryngology-Head and Neck Surgery
      Foundation. Published by Mosby, Inc. All rights reserved.
FAU - Erkalp, Kerem
AU  - Erkalp K
AD  - Department of Anesthesiology, Vakif Gureba Training and Research Hospital,
      Istanbul, Turkey.
FAU - Korkut, Yasemin Arzu
AU  - Korkut YA
FAU - Meric, Aysenur
AU  - Meric A
FAU - Kahya, Volkan
AU  - Kahya V
FAU - Gedikli, Orhan
AU  - Gedikli O
FAU - Su, Ozlem Kucuk
AU  - Su OK
FAU - Saitoglu, Leyla
AU  - Saitoglu L
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20100320
PL  - England
TA  - Otolaryngol Head Neck Surg
JT  - Otolaryngology--head and neck surgery : official journal of American Academy of
      Otolaryngology-Head and Neck Surgery
JID - 8508176
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Intraoperative Care/methods
MH  - Male
MH  - Nose/*surgery
MH  - *Pharynx
MH  - Postoperative Complications
MH  - Prospective Studies
MH  - Stomatitis, Aphthous/*etiology
MH  - Tampons, Surgical/*adverse effects
EDAT- 2010/04/27 06:00
MHDA- 2010/05/07 06:00
CRDT- 2010/04/27 06:00
PHST- 2009/10/01 00:00 [received]
PHST- 2009/12/17 00:00 [revised]
PHST- 2009/12/22 00:00 [accepted]
PHST- 2010/04/27 06:00 [entrez]
PHST- 2010/04/27 06:00 [pubmed]
PHST- 2010/05/07 06:00 [medline]
AID - S0194-5998(09)01938-X [pii]
AID - 10.1016/j.otohns.2009.12.040 [doi]
PST - ppublish
SO  - Otolaryngol Head Neck Surg. 2010 May;142(5):672-6. doi:
      10.1016/j.otohns.2009.12.040. Epub 2010 Mar 20.


PMID- 20416063
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20100520
LR  - 20220310
IS  - 1742-6405 (Electronic)
IS  - 1742-6405 (Linking)
VI  - 7
DP  - 2010 Apr 23
TI  - Experiences in conducting multiple community-based HIV prevention trials among
      women in KwaZulu-Natal, South Africa.
PG  - 10
LID - 10.1186/1742-6405-7-10 [doi]
AB  - BACKGROUND: South Africa, with its scientific capacity, good infrastructure and
      high HIV incidence rates, is ideally positioned to conduct large-scale HIV
      prevention trials. The HIV Prevention Research Unit of the South African Medical 
      Research Council conducted four phase III and one phase IIb trials of
      women-initiated HIV prevention options in KwaZulu-Natal between 2003 and 2009. A 
      total of 7046 women participated, with HIV prevalence between 25% and 45% and HIV
      incidence ranging from 4.5-9.1% per year. Unfortunately none of the interventions
      tested had any impact on reducing the risk of HIV acquisition; however, extremely
      valuable experience was gained, lessons learned and capacity built, while the
      communities gained associated benefits. EXPERIENCE: Our experience in conducting 
      these trials ranged from setting up community partnerships to developing clinical
      research sites and dissemination of trial results. Community engagement included 
      setting up community-based research sites with approval from both political and
      traditional leaders, and developing community advisory groups to assist with the 
      research process. Community-wide education on HIV/sexually transmitted infection 
      prevention, treatment and care was provided to over 90,000 individuals. Myths and
      misconceptions were addressed through methods such as anonymous suggestion boxes 
      in clinic waiting areas and intensive education and counselling. Attempts were
      made to involve male partners to foster support and facilitate recruitment of
      women. Peer educator programmes were initiated to provide ongoing education and
      also to facilitate recruitment of women to the trials. Recruitment strategies
      such as door-to-door recruitment and community group meetings were initiated.
      Over 90% of women enrolled were retained. Community benefits from the trial
      included education on HIV prevention, treatment and care and provision of
      ancillary care (such as Pap smears, reproductive health care and referral for
      chronic illnesses). Social benefits included training of home-based caregivers
      and sustainable ongoing HIV prevention education through peer educator
      programmes. CHALLENGES: Several challenges were encountered, including
      manipulation by participants of their eligibility criteria in order to enroll in 
      the trial. Women attempted to co-enroll in multiple trials to benefit from
      financial reimbursements and individualised care. The trials became ethically
      challenging when participants refused to take up referrals for care due to
      stigma, denial of their HIV status and inadequate health infrastructure. Lack of 
      disclosure of HIV status to partners and family members was particularly
      challenging. Some of the ethical dilemmas put to the test our responsibility as
      researchers and our obligation to provide health care to research participants.
      CONCLUSION: Conducting these five trials in a period of six years provided us
      with invaluable insights into trial implementation, community participation,
      recruitment and retention, provision of care and dissemination of trial results. 
      The critical mass of scientists trained as clinical trialists will continue to
      address the relentless HIV epidemic in our setting and ensure our commitment to
      finding a biomedical HIV prevention option for women in the future.
FAU - Ramjee, Gita
AU  - Ramjee G
AD  - HIV Prevention Research Unit, South African Medical Research Council, 123 Jan
      Hofmeyr Road, Westville, 3630, Durban, South Africa. Gita.Ramjee@mrc.ac.za
FAU - Coumi, Nicola
AU  - Coumi N
FAU - Dladla-Qwabe, Nozizwe
AU  - Dladla-Qwabe N
FAU - Ganesh, Shay
AU  - Ganesh S
FAU - Gappoo, Sharika
AU  - Gappoo S
FAU - Govinden, Roshini
AU  - Govinden R
FAU - Guddera, Vijayanand
AU  - Guddera V
FAU - Maharaj, Rashika
AU  - Maharaj R
FAU - Moodley, Jothi
AU  - Moodley J
FAU - Morar, Neetha
AU  - Morar N
FAU - Naidoo, Sarita
AU  - Naidoo S
FAU - Palanee, Thesla
AU  - Palanee T
LA  - eng
GR  - G0100137/MRC_/Medical Research Council/United Kingdom
GR  - MC_U122861322/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
DEP - 20100423
PL  - England
TA  - AIDS Res Ther
JT  - AIDS research and therapy
JID - 101237921
PMC - PMC2869332
EDAT- 2010/04/27 06:00
MHDA- 2010/04/27 06:01
CRDT- 2010/04/27 06:00
PHST- 2010/02/16 00:00 [received]
PHST- 2010/04/23 00:00 [accepted]
PHST- 2010/04/27 06:00 [entrez]
PHST- 2010/04/27 06:00 [pubmed]
PHST- 2010/04/27 06:01 [medline]
AID - 1742-6405-7-10 [pii]
AID - 10.1186/1742-6405-7-10 [doi]
PST - epublish
SO  - AIDS Res Ther. 2010 Apr 23;7:10. doi: 10.1186/1742-6405-7-10.


PMID- 20415964
OWN - NLM
STAT- MEDLINE
DCOM- 20100812
LR  - 20191210
IS  - 1466-769X (Electronic)
IS  - 1466-7681 (Linking)
VI  - 11
IP  - 2
DP  - 2010 Apr
TI  - Moral instability: the upsides for nursing practice.
PG  - 127-35
LID - 10.1111/j.1466-769X.2010.00434.x [doi]
AB  - This article briefly outlines some of the key problems with the way in which the 
      moral realm has traditionally been understood and analysed. I propose two
      alternative views of what is morally interesting and applicable to nursing
      practice and I indicate that instability has its upsides. I begin with a moral
      tale - a 'Good Samaritan' story - which raises fairly usual questions about the
      nature of morality but also the more philosophically fundamental question about
      the relationship between subjectivity and moral agency. I then consider this
      relationship from the perspectives of two twentieth century philosophers:
      Emmanuel Levinas and Michel Foucault. Levinas' basic point is that the experience
      of ethical subjectivity is made possible through others: the demand to respond to
      the existence of others is the basic social structure that precedes individual
      freedom. If Levinas posits intersubjectivity as a fundamental or primitive
      feature of the moral realm, Foucault poses an even more basic question: how have 
      moral subjects and relations of obligation been constituted? The aim of ethical
      inquiry, for Foucault, is to describe the network of discourses, institutions,
      relations, and practices through which certain kinds of subjects are constituted 
      and constitute themselves, e.g. as a kind of person who can act morally. Finally,
      I consider some recent research in philosophy of nursing which illustrates how
      Levinasian and/or Foucauldian perspectives can deepen understanding of nurses'
      moral practices, specifically, the work of Norwegian public health nurses,
      Canadian pediatric nurses, and Irish midwives. I suggest that in spite of the
      instability of morality in general and the particular ethical challenges that
      face nurses, there are grounds for hope and possible strategies for living in
      unstable times.
FAU - McCarthy, Joan
AU  - McCarthy J
AD  - Lecturer, Healthcare Ethics, School of Nursing and Midwifery, Brookfield Health
      Sciences Complex, University College Cork, Cork, Ireland. j.mccarthy@ucc.ie
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Philos
JT  - Nursing philosophy : an international journal for healthcare professionals
JID - 100897394
SB  - IM
MH  - Altruism
MH  - Attitude of Health Personnel
MH  - Empathy
MH  - Ethical Analysis
MH  - *Ethical Theory
MH  - Existentialism/psychology
MH  - Humans
MH  - Moral Obligations
MH  - *Morals
MH  - Motivation
MH  - Nurse's Role/*psychology
MH  - Nurse-Patient Relations/*ethics
MH  - *Philosophy, Nursing
MH  - Power, Psychological
MH  - Self Concept
MH  - Self-Assessment
EDAT- 2010/04/27 06:00
MHDA- 2010/08/13 06:00
CRDT- 2010/04/27 06:00
PHST- 2010/04/27 06:00 [entrez]
PHST- 2010/04/27 06:00 [pubmed]
PHST- 2010/08/13 06:00 [medline]
AID - NUP434 [pii]
AID - 10.1111/j.1466-769X.2010.00434.x [doi]
PST - ppublish
SO  - Nurs Philos. 2010 Apr;11(2):127-35. doi: 10.1111/j.1466-769X.2010.00434.x.


PMID- 20415962
OWN - NLM
STAT- MEDLINE
DCOM- 20100812
LR  - 20191210
IS  - 1466-769X (Electronic)
IS  - 1466-7681 (Linking)
VI  - 11
IP  - 2
DP  - 2010 Apr
TI  - Citizen minds, citizen bodies: the citizenship experience and the government of
      mentally ill persons.
PG  - 100-11
LID - 10.1111/j.1466-769X.2010.00437.x [doi]
AB  - The concept of citizenship is becoming more and more prominent in specific
      fields, such as psychiatry/mental health, where it is constituted as a solution
      to the issues of exclusion, discrimination, and poverty often endured by the
      mentally ill. We argue that such discourse of citizenship represents a break in
      the history of psychiatry and constitutes a powerful strategy to counter the
      effects of equally powerful psychiatric labelling. However, we call into question
      the emancipatory promise of a citizenship agenda. Foucault's concept of
      governmentality is helpful in understanding the production of the citizen
      subject, its location within the 'art of government', as well as the ethical and 
      political implications of citizenship in the context of mental health.
FAU - Perron, Amelie
AU  - Perron A
AD  - Assistant Professor, School of Nursing, Faculty of Health Sciences, University of
      Ottawa, Ottawa, ON, Canada. amelie.perron@uottawa.ca
FAU - Rudge, Trudy
AU  - Rudge T
FAU - Holmes, Dave
AU  - Holmes D
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Philos
JT  - Nursing philosophy : an international journal for healthcare professionals
JID - 100897394
SB  - IM
MH  - *Civil Rights
MH  - Freedom
MH  - *Government
MH  - Humans
MH  - *Mentally Ill Persons
MH  - Philosophy, Medical
MH  - *Politics
MH  - Postmodernism
MH  - Power, Psychological
MH  - Psychiatry/*organization & administration
MH  - Social Identification
MH  - *Social Responsibility
MH  - Western World
EDAT- 2010/04/27 06:00
MHDA- 2010/08/13 06:00
CRDT- 2010/04/27 06:00
PHST- 2010/04/27 06:00 [entrez]
PHST- 2010/04/27 06:00 [pubmed]
PHST- 2010/08/13 06:00 [medline]
AID - NUP437 [pii]
AID - 10.1111/j.1466-769X.2010.00437.x [doi]
PST - ppublish
SO  - Nurs Philos. 2010 Apr;11(2):100-11. doi: 10.1111/j.1466-769X.2010.00437.x.


PMID- 20414923
OWN - NLM
STAT- MEDLINE
DCOM- 20100513
LR  - 20100423
IS  - 1107-0625 (Print)
IS  - 1107-0625 (Linking)
VI  - 15
IP  - 1
DP  - 2010 Jan-Mar
TI  - Cardiopulmonary resuscitation in end-stage cancer patients.
PG  - 25-8
AB  - Cardiopulmonary resuscitation (CPR) in patients with end-stage cancer is an issue
      of significant clinical and ethical importance. In general, the overall survival 
      to discharge in cancer patients is referred to be 6.2% (localised - 9.5% vs.
      metastatic disease - 5.6%) compared to 15% of unselected in-hospital arrests.
      However, immediate survival, as well as survival to discharge after a successful 
      CPR is affected by multiple factors. Type and extend of tumor, degree of clinical
      deterioration, functional status and many other factors do correlate with outcome
      in different degrees. Critical illness scoring systems are commonly used in order
      to assess performance status of patients and predict outcome. This article will
      review all the above mentioned factors, as well as patients' perception about
      "do-not-resuscitate" orders and palliative care.
FAU - Myrianthefs, P
AU  - Myrianthefs P
AD  - Intensive Care Unit, KAT General Hospital, Nursing School, University of Athens, 
      Athens, Greece. pmiriant@nurs.uoa.gr
FAU - Batistaki, C
AU  - Batistaki C
FAU - Baltopoulos, G
AU  - Baltopoulos G
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Cyprus
TA  - J BUON
JT  - Journal of B.U.ON. : official journal of the Balkan Union of Oncology
JID - 100883428
SB  - IM
MH  - *Cardiopulmonary Resuscitation/psychology
MH  - Comprehension
MH  - Health Knowledge, Attitudes, Practice
MH  - Health Status Indicators
MH  - Hospital Mortality
MH  - Humans
MH  - Neoplasms/complications/mortality/psychology/*therapy
MH  - *Palliative Care/psychology
MH  - Perception
MH  - Resuscitation Orders
MH  - Risk Assessment
MH  - Risk Factors
MH  - *Terminally Ill/psychology
MH  - Treatment Outcome
RF  - 24
EDAT- 2010/04/24 06:00
MHDA- 2010/05/14 06:00
CRDT- 2010/04/24 06:00
PHST- 2010/04/24 06:00 [entrez]
PHST- 2010/04/24 06:00 [pubmed]
PHST- 2010/05/14 06:00 [medline]
PST - ppublish
SO  - J BUON. 2010 Jan-Mar;15(1):25-8.


PMID- 20414667
OWN - NLM
STAT- MEDLINE
DCOM- 20101210
LR  - 20211020
IS  - 1432-2099 (Electronic)
IS  - 0301-634X (Linking)
VI  - 49
IP  - 3
DP  - 2010 Aug
TI  - Accepting space radiation risks.
PG  - 325-9
LID - 10.1007/s00411-010-0286-0 [doi]
AB  - The human exploration of space inevitably involves exposure to radiation.
      Associated with this exposure are multiple risks, i.e., probabilities that
      certain aspects of an astronaut's health or performance will be degraded. The
      management of these risks requires that such probabilities be accurately
      predicted, that the actual exposures be verified, and that comprehensive records 
      be maintained. Implicit in these actions is the fact that, at some point, a
      decision has been made to accept a certain level of risk. This paper examines
      ethical and practical considerations involved in arriving at a determination that
      risks are acceptable, roles that the parties involved may play, and obligations
      arising out of reliance on the informed consent paradigm seen as the basis for
      ethical radiation risk acceptance in space.
FAU - Schimmerling, Walter
AU  - Schimmerling W
AD  - NASA/USRA, Washington, DC 20015, USA., walter2205@mac.com
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100423
PL  - Germany
TA  - Radiat Environ Biophys
JT  - Radiation and environmental biophysics
JID - 0415677
SB  - IM
MH  - *Astronauts
MH  - Environmental Exposure/*adverse effects
MH  - Humans
MH  - Informed Consent
MH  - *Radiation Injuries/epidemiology
MH  - Risk Assessment
MH  - Risk Management
MH  - *Space Flight
EDAT- 2010/04/24 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/04/24 06:00
PHST- 2009/10/14 00:00 [received]
PHST- 2010/04/05 00:00 [accepted]
PHST- 2010/04/24 06:00 [entrez]
PHST- 2010/04/24 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1007/s00411-010-0286-0 [doi]
PST - ppublish
SO  - Radiat Environ Biophys. 2010 Aug;49(3):325-9. doi: 10.1007/s00411-010-0286-0.
      Epub 2010 Apr 23.


PMID- 20414623
OWN - NLM
STAT- MEDLINE
DCOM- 20100803
LR  - 20100423
IS  - 1678-4561 (Electronic)
IS  - 1413-8123 (Linking)
VI  - 15
IP  - 2
DP  - 2010 Mar
TI  - [Hearing evaluation on newborn babies and its ethical implications].
PG  - 559-62
LID - 10.1590/S1413-81232010000200032 [doi]
LID - S1413-81232010000200032 [pii]
AB  - The study has as purpose to examine the bibliographic production that
      investigates the use of the test of otoacoustic emissions in newborn babies done 
      in hospitals. It gives emphasis in the approval of the mentioned article along
      the Research Ethics Committee. The method consists on bibliographic revision of
      national articles published in Brazilian journals. The research was realized in
      databases of the virtual library in health (http://www.bireme.br) and at the
      search engine Google (http://www.google.com.br), considering the period of 2004
      to 2006. The key words used were: otoacoustic emissions and hearing triage or
      equivalent expressions in newborn babies in hospitals. Another source was the
      manual search in reference lists of the selected articles. After the application 
      of the inclusion rules, nine articles were selected in five different journals.
      The citation of the approval of the Ethics Committee and the signature of the
      Free Consent Term, which were cleared by the responsible, were present in the
      majority of the articles and it demonstrates the concern and respect of the
      researchers of this area with the participant citizen on the study.
FAU - Guimaraes, Valeriana de Castro
AU  - Guimaraes Vde C
AD  - Hospital das Clinicas, Universidade Federal de Goias, Goiania, GO, 74605-050.
      guimaraesvc@bol.com.br
FAU - Barbosa, Maria Alves
AU  - Barbosa MA
LA  - por
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Avaliacao auditiva no recem-nascido e suas implicacoes eticas.
PL  - Brazil
TA  - Cien Saude Colet
JT  - Ciencia & saude coletiva
JID - 9713483
SB  - IM
MH  - Hearing Tests/*ethics
MH  - Humans
MH  - Infant, Newborn
MH  - Retrospective Studies
RF  - 18
EDAT- 2010/04/24 06:00
MHDA- 2010/08/04 06:00
CRDT- 2010/04/24 06:00
PHST- 2007/07/04 00:00 [received]
PHST- 2007/12/20 00:00 [accepted]
PHST- 2010/04/24 06:00 [entrez]
PHST- 2010/04/24 06:00 [pubmed]
PHST- 2010/08/04 06:00 [medline]
AID - S1413-81232010000200032 [pii]
AID - 10.1590/S1413-81232010000200032 [doi]
PST - ppublish
SO  - Cien Saude Colet. 2010 Mar;15(2):559-62. doi: 10.1590/S1413-81232010000200032.


PMID- 20414520
OWN - NLM
STAT- MEDLINE
DCOM- 20101006
LR  - 20190606
IS  - 1678-4170 (Electronic)
IS  - 0066-782X (Linking)
VI  - 94
IP  - 1
DP  - 2010 Jan
TI  - [Informed consent as viewed by patients participating in cardiology drug trial].
PG  - 4-9
LID - S0066-782X2010000100003 [pii]
AB  - BACKGROUND: In clinical tests, the Informed Consent is critical to preserve the
      ethics, but due to its high complexity level, it cannot be fully understood. This
      study assesses the Informed Consent as viewed by patients. OBJECTIVE: We
      addressed the issue of what do patients understand about the studies based on the
      IC. METHODS: We invited participants of outpatient clinical drug trials phase II,
      III and IV to answer a questionnaire with 29 questions, such as: why have you
      accepted to participate? Did you read the Informed Consent before signing it? By 
      signing it, were you sure you have fully understood it? Eighty individuals (20
      women and 60 men) showed up, from 106 patients. The variables of each question
      were considered as often as they appeared. The comparison of the averages among
      the groups was made by t tests of Student or Wilcoxon; and for associations,
      Chi-square or Likelihood Ratio, or Fisher's exact test. RESULTS: Ages averaged
      58.7 +/- 9.3 years. Concerning their reasons to taking part in the survey, 66.2% 
      pointed out their own benefit; 42.5%, for science's sake; 25.0% claimed they were
      doing so at their doctor's request; 50% did not understand the Informed Consent
      properly; and 32.9% did not read it, but signed it. Among those who were
      administered placebo after randomization (n = 47), 66.7% did not understand the
      meaning of the informed consent. A strong correlation between failure to
      understand the meaning of placebo with literacy level (p = 0,02) was verified,
      which is an evidence that the smaller is the literacy level, the smaller is the
      understanding level. CONCLUSION: The Informed Consent is poorly understood by
      patients and for some of them, trusting a doctor affected their decision in
      taking part in the clinical trial with drugs. Their literacy level also
      influenced their understanding of the term 'placebo'.
FAU - Meneguin, Silmara
AU  - Meneguin S
AD  - Instituto do Coracao, Hospital das Clinicas, Faculdade de Medicina, USP, Sao
      Paulo, SP, Brasil.
FAU - Zoboli, Elma L C P
AU  - Zoboli EL
FAU - Domingues, Raquel Z L
AU  - Domingues RZ
FAU - Nobre, Moacyr R
AU  - Nobre MR
FAU - Cesar, Luiz A M
AU  - Cesar LA
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Entendimento do termo de consentimento por pacientes participes em pesquisas com 
      farmaco na cardiologia.
PL  - Brazil
TA  - Arq Bras Cardiol
JT  - Arquivos brasileiros de cardiologia
JID - 0421031
SB  - IM
MH  - Cardiology
MH  - Chi-Square Distribution
MH  - *Clinical Trials as Topic
MH  - *Comprehension
MH  - Educational Status
MH  - Female
MH  - Humans
MH  - Informed Consent/*psychology/statistics & numerical data
MH  - Male
MH  - Mental Competency/*psychology
MH  - Middle Aged
MH  - Motivation
MH  - Statistics, Nonparametric
EDAT- 2010/04/24 06:00
MHDA- 2010/10/07 06:00
CRDT- 2010/04/24 06:00
PHST- 2009/01/27 00:00 [received]
PHST- 2009/06/23 00:00 [accepted]
PHST- 2010/04/24 06:00 [entrez]
PHST- 2010/04/24 06:00 [pubmed]
PHST- 2010/10/07 06:00 [medline]
AID - S0066-782X2010000100003 [pii]
AID - 10.1590/s0066-782x2010000100003 [doi]
PST - ppublish
SO  - Arq Bras Cardiol. 2010 Jan;94(1):4-9. doi: 10.1590/s0066-782x2010000100003.


PMID- 20414442
OWN - NLM
STAT- MEDLINE
DCOM- 20100729
LR  - 20211020
IS  - 1553-6467 (Electronic)
IS  - 0002-9459 (Linking)
VI  - 74
IP  - 2
DP  - 2010 Mar 10
TI  - Relationship between case question prompt format and the quality of responses.
PG  - 29
AB  - OBJECTIVES: To compare the effectiveness of 2 case question formats (multiple
      choice and open ended) to prompt faculty members and students to explore multiple
      solutions and use factual evidence to defend their solutions. METHODS: Doctor of 
      pharmacy (PharmD) faculty members and students responded to 2 pharmacy law/ethics
      cases, one followed by a case question prompt in multiple-choice format and the
      other by a question in open-ended format. The number of conclusions and the
      quality of the arguments generated were assessed using general linear modeling.
      RESULTS: PharmD faculty members outperformed students on every outcome variable
      measured, demonstrating expert problem-solving skills. All participants provided 
      better quality arguments when the case prompt question was in multiple-choice
      format. CONCLUSIONS: The better quality arguments prompted by multiple-choice
      case questions suggests this format should be used when constructing case
      question prompts.
FAU - Medina, Melissa S
AU  - Medina MS
AD  - College of Pharmacy, University of Oklahoma Health Science Center, 1110 N.
      Stonewall Ave., PO Box 26901, Oklahoma City, OK 73126, USA.
      melissa-medina@ouhsc.edu
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Am J Pharm Educ
JT  - American journal of pharmaceutical education
JID - 0372650
RN  - 0 (Prescription Drugs)
SB  - IM
MH  - Adult
MH  - Contraindications
MH  - *Drug Prescriptions
MH  - Education, Pharmacy/*methods
MH  - Educational Status
MH  - Evidence-Based Practice
MH  - Faculty
MH  - Female
MH  - Health Insurance Portability and Accountability Act
MH  - Humans
MH  - *Legislation, Drug
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Prescription Drugs/adverse effects/toxicity
MH  - *Problem Solving
MH  - Problem-Based Learning/*methods
MH  - Professional Competence
MH  - *Surveys and Questionnaires
MH  - United States
MH  - Young Adult
PMC - PMC2856418
OTO - NOTNLM
OT  - active learning
OT  - argument analysis
OT  - case-based learning
OT  - problem solving
OT  - question format
EDAT- 2010/04/24 06:00
MHDA- 2010/07/30 06:00
CRDT- 2010/04/24 06:00
PHST- 2009/07/01 00:00 [received]
PHST- 2009/08/27 00:00 [accepted]
PHST- 2010/04/24 06:00 [entrez]
PHST- 2010/04/24 06:00 [pubmed]
PHST- 2010/07/30 06:00 [medline]
AID - 10.5688/aj740229 [doi]
PST - ppublish
SO  - Am J Pharm Educ. 2010 Mar 10;74(2):29. doi: 10.5688/aj740229.


PMID- 20414376
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20100628
LR  - 20220410
IS  - 1865-1380 (Electronic)
IS  - 1865-1372 (Linking)
VI  - 3
IP  - 1
DP  - 2010 Feb 16
TI  - Medical student disaster medicine education: the development of an educational
      resource.
PG  - 9-20
LID - 10.1007/s12245-009-0140-9 [doi]
AB  - BACKGROUND: Disaster medicine education is an enormous challenge, but
      indispensable for disaster preparedness. AIMS: We aimed to develop and implement 
      a disaster medicine curriculum for medical student education that can serve as a 
      peer-reviewed, structured educational guide and resource. Additionally, the
      process of designing, approving and implementing such a curriculum is presented. 
      METHODS: The six-step approach to curriculum development for medical education
      was used as a formal process instrument. Recognized experts from professional and
      governmental bodies involved in disaster health care provided input using
      disaster-related physician training programs, scientific evidence if available,
      proposals for education by international disaster medicine organizations and
      their expertise as the basis for content development. RESULTS: The final course
      consisted of 14 modules composed of 2-h units. The concepts of disaster medicine,
      including response, medical assistance, law, command, coordination,
      communication, and mass casualty management, are introduced. Hospital
      preparedness plans and experiences from worldwide disaster assistance are
      reviewed. Life-saving emergency and limited individual treatment under disaster
      conditions are discussed. Specifics of initial management of explosive,
      war-related, radiological/nuclear, chemical, and biological incidents emphasizing
      infectious diseases and terrorist attacks are presented. An evacuation exercise
      is completed, and a mass casualty triage is simulated in collaboration with local
      disaster response agencies. Decontamination procedures are demonstrated at a
      nuclear power plant or the local fire department, and personal decontamination
      practices are exercised. Mannequin resuscitation is practiced while personal
      protective equipment is utilized. An interactive review of professional ethics,
      stress disorders, psychosocial interventions, and quality improvement efforts
      complete the training. CONCLUSIONS: The curriculum offers medical disaster
      education in a reasonable time frame, interdisciplinary format, and
      multi-experiential course. It can serve as a template for basic medical student
      disaster education. Because of its comprehensive but flexible structure, it
      should also be helpful for other health-care professional student disaster
      education programs.
FAU - Pfenninger, Ernst G
AU  - Pfenninger EG
AD  - Department of Anesthesiology, University Hospital of Ulm, Steinhovelstr. Ulm,
      Germany. ernst.pfenninger@uni-ulm.de
FAU - Domres, Bernd D
AU  - Domres BD
FAU - Stahl, Wolfgang
AU  - Stahl W
FAU - Bauer, Andreas
AU  - Bauer A
FAU - Houser, Christine M
AU  - Houser CM
FAU - Himmelseher, Sabine
AU  - Himmelseher S
LA  - eng
PT  - Journal Article
DEP - 20100216
PL  - England
TA  - Int J Emerg Med
JT  - International journal of emergency medicine
JID - 101469435
PMC - PMC2850977
OTO - NOTNLM
OT  - Curriculum
OT  - Disasters
OT  - Medical education
OT  - Medical students
EDAT- 2010/04/24 06:00
MHDA- 2010/04/24 06:01
CRDT- 2010/04/24 06:00
PHST- 2009/07/08 00:00 [received]
PHST- 2009/11/04 00:00 [accepted]
PHST- 2010/04/24 06:00 [entrez]
PHST- 2010/04/24 06:00 [pubmed]
PHST- 2010/04/24 06:01 [medline]
AID - 10.1007/s12245-009-0140-9 [doi]
PST - epublish
SO  - Int J Emerg Med. 2010 Feb 16;3(1):9-20. doi: 10.1007/s12245-009-0140-9.


PMID- 20413774
OWN - NLM
STAT- MEDLINE
DCOM- 20100524
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 255
IP  - 2
DP  - 2010 May
TI  - Inflammation within carotid atherosclerotic plaque: assessment with late-phase
      contrast-enhanced US.
PG  - 638-44
LID - 10.1148/radiol.10091365 [doi]
AB  - PURPOSE: To determine if the number of nontargeted microbubbles retained in human
      carotid plaque is sufficient to be detected with ultrasonography (US). MATERIALS 
      AND METHODS: The study protocol was approved by the local research ethics
      committee. Informed consent was obtained. A total of 37 subjects with carotid
      atherosclerosis (mean age, 69.9 years; age range, 49-86 years), of whom 27 (73%) 
      were men (mean age, 69.7 years; age range, 58-86 years) and 10 (27%) were women
      (mean age, 70.3 years; age range, 49-86 years), were studied between December
      2008 and May 2009 with late-phase (LP) contrast material-enhanced US by using
      flash imaging with a nonlinear mode at an intermediate mechanical index of 0.34 6
      minutes after bolus contrast agent injection. Plaques were defined as symptomatic
      if symptoms consistent with stroke, transient ischemic attack, or amaurosis fugax
      had occurred in the neurovascular territory of the plaque studied within 12
      months prior to entry into the study. Plaques were defined as asymptomatic if no 
      such events had ever occurred within the neurovascular territory. Raw linear data
      were used to quantify echogenicity of the plaque, which was normalized to lumen
      echogenicity. Gray-scale median score was also calculated. RESULTS: Of the 37
      subjects, 16 (43%) had symptomatic plaques and 21 (57%) had asymptomatic plaques.
      All examinations yielded evaluable LP contrast-enhanced US data. Normalized LP
      plaque echogenicity was greater in the symptomatic group (0.39; 95% confidence
      interval: -0.11, 0.89) than in the asymptomatic group (0.69; 95% confidence
      interval: -1.04, -0.34) (P = .0005). There was a moderate (rho = -0.44, P = .016)
      inverse correlation between normalized LP plaque echogenicity and gray-scale
      median score. CONCLUSION: By quantifying microbubble retention within the carotid
      plaque, LP contrast-enhanced US depicts clear differences between groups of
      subjects with plaque ipsilateral to symptoms and asymptomatic plaques. This
      technique has promise as a tissue-specific marker of inflammation and a potential
      role in the risk stratification of atherosclerotic carotid stenosis.
FAU - Owen, David R
AU  - Owen DR
AD  - Department of Experimental Medicine and Toxicology, Imperial College London,
      Hammersmith Hospital, Du Cane Road, London W12 0NN, England.
      d.owen@imperial.ac.uk
FAU - Shalhoub, Joseph
AU  - Shalhoub J
FAU - Miller, Sam
AU  - Miller S
FAU - Gauthier, Thomas
AU  - Gauthier T
FAU - Doryforou, Ortansia
AU  - Doryforou O
FAU - Davies, Alun H
AU  - Davies AH
FAU - Leen, Edward L S
AU  - Leen EL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - 0 (Phospholipids)
RN  - 0 (contrast agent BR1)
RN  - WS7LR3I1D6 (Sulfur Hexafluoride)
SB  - IM
CIN - Radiology. 2010 Nov;257(2):588-9; author reply 589. PMID: 20959553
MH  - Aged
MH  - Aged, 80 and over
MH  - Analysis of Variance
MH  - Carotid Artery Diseases/*diagnostic imaging/pathology
MH  - Contrast Media/administration & dosage
MH  - Female
MH  - Humans
MH  - Inflammation/diagnostic imaging/pathology
MH  - Injections, Intravenous
MH  - Male
MH  - Microbubbles
MH  - Middle Aged
MH  - Phospholipids/administration & dosage
MH  - Prospective Studies
MH  - Sensitivity and Specificity
MH  - Sulfur Hexafluoride/administration & dosage
MH  - Ultrasonography
EDAT- 2010/04/24 06:00
MHDA- 2010/05/25 06:00
CRDT- 2010/04/24 06:00
PHST- 2010/04/24 06:00 [entrez]
PHST- 2010/04/24 06:00 [pubmed]
PHST- 2010/05/25 06:00 [medline]
AID - 255/2/638 [pii]
AID - 10.1148/radiol.10091365 [doi]
PST - ppublish
SO  - Radiology. 2010 May;255(2):638-44. doi: 10.1148/radiol.10091365.


PMID- 20413773
OWN - NLM
STAT- MEDLINE
DCOM- 20100524
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 255
IP  - 2
DP  - 2010 May
TI  - Screening for lung cancer with digital chest radiography: sensitivity and number 
      of secondary work-up CT examinations.
PG  - 629-37
LID - 10.1148/radiol.09091308 [doi]
AB  - PURPOSE: To estimate the performance of digital chest radiography for detection
      of lung cancer. MATERIALS AND METHODS: The study had ethics committee approval,
      and a nested case-control design was used and included 55 patients with lung
      cancer detected at computed tomography (CT) and confirmed with histologic
      examination and a sample of 72 of 4873 control subjects without nodules at CT.
      All patients underwent direct-detector digital chest radiography in two
      projections within 2 months of the screening CT. Four radiologists with varying
      experience identified and localized potential cancers on chest radiographs by
      using a confidence scale of level 1 (no lesion) to 5 (definite lesion).
      Localization receiver operating characteristic (ROC) analysis was performed. On
      the basis of the assumption that suspicious lesions seen at chest radiography
      would lead to further work-up with CT, the number of work-up CT examinations per 
      detected cancer (CT examinations per cancer) was calculated at various confidence
      levels for the screening population (cancer rate in study population, 1.3%).
      RESULTS: Tumor size ranged from 6.8 to 50.7 mm (median, 11.8 mm). Areas under the
      localization ROC curve ranged from 0.52 to 0.69. Detection rates substantially
      varied with the observers' experience and confidence level: At a confidence level
      of 5, detection rates ranged from 18% at one CT examination per cancer to 53% at 
      13 CT examinations per cancer. At a confidence level of 2 or higher, detection
      rates ranged from 94% at 62 CT examinations per cancer to 78% at 44 CT
      examinations per cancer. CONCLUSION: A detection rate of 94% for lung tumors with
      a diameter of 6.8-50.7 mm found at CT screening was achievable with chest
      radiography only at the expense of a high false-positive rate and an excessive
      number of work-up CT examinations. Detection performance is strongly observer
      dependent.
FAU - de Hoop, Bartjan
AU  - de Hoop B
AD  - Department of Radiology, University Medical Center, Heidelberglaan 100, 3584 CX
      Utrecht, the Netherlands. B.J.dehoop@umcutrecht.nl
FAU - Schaefer-Prokop, Cornelia
AU  - Schaefer-Prokop C
FAU - Gietema, Hester A
AU  - Gietema HA
FAU - de Jong, Pim A
AU  - de Jong PA
FAU - van Ginneken, Bram
AU  - van Ginneken B
FAU - van Klaveren, Rob J
AU  - van Klaveren RJ
FAU - Prokop, Mathias
AU  - Prokop M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Aged
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/*diagnostic imaging/pathology
MH  - Male
MH  - Middle Aged
MH  - ROC Curve
MH  - Radiography, Thoracic/*methods
MH  - Sensitivity and Specificity
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2010/04/24 06:00
MHDA- 2010/05/25 06:00
CRDT- 2010/04/24 06:00
PHST- 2010/04/24 06:00 [entrez]
PHST- 2010/04/24 06:00 [pubmed]
PHST- 2010/05/25 06:00 [medline]
AID - 255/2/629 [pii]
AID - 10.1148/radiol.09091308 [doi]
PST - ppublish
SO  - Radiology. 2010 May;255(2):629-37. doi: 10.1148/radiol.09091308.


PMID- 20413769
OWN - NLM
STAT- MEDLINE
DCOM- 20100524
LR  - 20100423
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 255
IP  - 2
DP  - 2010 May
TI  - Structural and functional hippocampal changes in multiple sclerosis patients with
      intact memory function.
PG  - 595-604
LID - 10.1148/radiol.10091433 [doi]
AB  - PURPOSE: To investigate changes in hippocampal functional connectivity and
      structural measures of hippocampal damage in multiple sclerosis (MS) patients
      with intact spatial memory, a cognitive domain frequently affected in progressive
      MS. MATERIALS AND METHODS: The study protocol was approved by the institutional
      ethics review board; all subjects gave written informed consent prior to
      participation. Twenty-five MS patients with intact spatial memory function were
      compared with 30 age- and sex-matched controls. Hippocampal volume differences,
      based on manually drawn masks, were evaluated by using the Student t test.
      Additionally, focal hippocampal lesions and mean diffusivity were obtained as
      descriptive measures of structural hippocampal damage. Multiple regression
      analyses of the resting-state functional magnetic resonance (MR) imaging data
      were performed for each subject by using hippocampal time series. Between-group
      analyses were conducted with a mixed-effects model, corrected for multiple
      comparisons by a cluster defining threshold level of z = 2 and a corrected
      cluster size significance level of P < .05. RESULTS: Right hippocampal volume was
      significantly lower in MS patients as compared with controls (P < .01). Left
      hippocampal volume was also lower in MS patients compared with controls, but not 
      significantly so (P = .09). Resting-state functional connectivity between the
      hippocampus and its anatomic input or target areas, including the anterior
      cingulate gyrus, thalamus, and prefrontal cortex, were significantly decreased in
      MS patients. Decreased hippocampal functional connectivity was more pronounced in
      a subgroup of MS patients with hippocampal atrophy, although subtle decreases of 
      functional connectivity were also found in patients with normal hippocampal
      volume. CONCLUSION: In MS patients, substantial abnormalities of hippocampal
      functional connectivity are already present before spatial memory function is
      impaired, especially in those patients with more pronounced hippocampal atrophy. 
      Longitudinal studies should now assess whether these functional connectivity and 
      structural changes may precede memory impairment in MS.
FAU - Roosendaal, Stefan D
AU  - Roosendaal SD
AD  - Department of Radiology, MS Center Amsterdam, VU University Medical Center, De
      Boelelaan 1117, 1007 MB Amsterdam, the Netherlands. s.roosendaal@vumc.nl
FAU - Hulst, Hanneke E
AU  - Hulst HE
FAU - Vrenken, Hugo
AU  - Vrenken H
FAU - Feenstra, Heleen E M
AU  - Feenstra HE
FAU - Castelijns, Jonas A
AU  - Castelijns JA
FAU - Pouwels, Petra J W
AU  - Pouwels PJ
FAU - Barkhof, Frederik
AU  - Barkhof F
FAU - Geurts, Jeroen J G
AU  - Geurts JJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adult
MH  - Brain Mapping
MH  - Case-Control Studies
MH  - Female
MH  - Hippocampus/*pathology/*physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - *Memory
MH  - Multiple Sclerosis/*pathology/*physiopathology
MH  - Neuropsychological Tests
MH  - Regression Analysis
MH  - Statistics, Nonparametric
EDAT- 2010/04/24 06:00
MHDA- 2010/05/25 06:00
CRDT- 2010/04/24 06:00
PHST- 2010/04/24 06:00 [entrez]
PHST- 2010/04/24 06:00 [pubmed]
PHST- 2010/05/25 06:00 [medline]
AID - 255/2/595 [pii]
AID - 10.1148/radiol.10091433 [doi]
PST - ppublish
SO  - Radiology. 2010 May;255(2):595-604. doi: 10.1148/radiol.10091433.


PMID- 20413768
OWN - NLM
STAT- MEDLINE
DCOM- 20100524
LR  - 20220410
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 255
IP  - 2
DP  - 2010 May
TI  - Cerebral, facial, and orbital involvement in Erdheim-Chester disease: CT and MR
      imaging findings.
PG  - 586-94
LID - 10.1148/radiol.10090320 [doi]
AB  - PURPOSE: To retrospectively review the brain magnetic resonance (MR) imaging and 
      computed tomographic (CT) findings in patients with Erdheim-Chester disease
      (ECD). MATERIALS AND METHODS: The ethics committee required neither institutional
      review board approval nor informed patient consent for retrospective analyses of 
      the patients' medical records and imaging data. The patients' medical files were 
      retrospectively reviewed in accordance with human subject research protocols.
      Three neuroradiologists in consensus analyzed the signal intensity, location,
      size, number, and gadolinium uptake of lesions detected on brain MR images
      obtained in 33 patients with biopsy-proved ECD. RESULTS: Thirty patients had
      intracranial, facial bone, and/or orbital involvement, and three had normal
      neurologic imaging findings. The hypothalamic-pituitary axis was involved in 16
      (53%) of the 30 patients, with six (20%) cases of micronodular or nodular masses 
      of the infundibular stalk. Meningeal lesions were observed in seven (23%)
      patients. Three (10%) patients had bilateral symmetric T2 high signal intensity
      in the dentate nucleus areas, and five (17%) had multiple intraaxial enhancing
      masses. Striking intracranial periarterial infiltration was observed in three
      (10%) patients. Another patient (3%) had a lesion in the lumen of the superior
      sagittal sinus. Nine (30%) patients had orbital involvement. Twenty-four (80%)
      patients had osteosclerosis of the facial and/or skull bones. At least two
      anatomic sites were involved in two-thirds (n = 20) of the patients.
      Osteosclerosis of the facial bones associated with orbital masses and either
      meningeal or infundibular stalk masses was seen in eight (27%) patients.
      CONCLUSION: Lesions of the brain, meninges, facial bones, and orbits are
      frequently observed and should be systematically sought on the brain MR and CT
      images obtained in patients with ECD, even if these patients are asymptomatic.
      Careful attention should be directed to the periarterial environment.
FAU - Drier, Aurelie
AU  - Drier A
AD  - Department of Neuroradiology, Pitie-Salpetriere Hospital, 47-83 Bd de l'Hopital, 
      75013 Paris, France. aureliedrier@gmail.com
FAU - Haroche, Julien
AU  - Haroche J
FAU - Savatovsky, Julien
AU  - Savatovsky J
FAU - Godeneche, Gaelle
AU  - Godeneche G
FAU - Dormont, Didier
AU  - Dormont D
FAU - Chiras, Jacques
AU  - Chiras J
FAU - Amoura, Zahir
AU  - Amoura Z
FAU - Bonneville, Fabrice
AU  - Bonneville F
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 6HG8UB2MUY (Meglumine)
RN  - L0ND3981AG (gadoterate meglumine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Biopsy
MH  - Brain Diseases/diagnostic imaging/*pathology
MH  - Contrast Media
MH  - Erdheim-Chester Disease/diagnostic imaging/*pathology
MH  - Facial Bones/diagnostic imaging/*pathology
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Meglumine
MH  - Middle Aged
MH  - Orbit/diagnostic imaging/*pathology
MH  - Organometallic Compounds
MH  - Retrospective Studies
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2010/04/24 06:00
MHDA- 2010/05/25 06:00
CRDT- 2010/04/24 06:00
PHST- 2010/04/24 06:00 [entrez]
PHST- 2010/04/24 06:00 [pubmed]
PHST- 2010/05/25 06:00 [medline]
AID - 255/2/586 [pii]
AID - 10.1148/radiol.10090320 [doi]
PST - ppublish
SO  - Radiology. 2010 May;255(2):586-94. doi: 10.1148/radiol.10090320.


PMID- 20413761
OWN - NLM
STAT- MEDLINE
DCOM- 20100524
LR  - 20220309
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 255
IP  - 2
DP  - 2010 May
TI  - Prostate tissue composition and MR measurements: investigating the relationships 
      between ADC, T2, K(trans), v(e), and corresponding histologic features.
PG  - 485-94
LID - 10.1148/radiol.10091343 [doi]
AB  - PURPOSE: To investigate relationships between magnetic resonance (MR) imaging
      measurements and the underlying composition of normal and malignant prostate
      tissue. MATERIALS AND METHODS: Twenty-four patients (median age, 63 years; age
      range, 44-72 years) gave informed consent to be examined for this research ethics
      board-approved study. Before undergoing prostatectomy, patients were examined
      with T2-weighted, diffusion-weighted, T2 mapping, and dynamic contrast
      material-enhanced MR imaging at 1.5 T. Maps of apparent diffusion coefficient
      (ADC), T2, volume transfer constant (K(trans)), and extravascular extracellular
      space (v(e)) were calculated. Whole-mount hematoxylin-eosin-stained sections were
      generated and digitized at histologic resolution. Percentage areas of tissue
      components (nuclei, cytoplasm, stroma, luminal space) were measured by using
      image segmentation. Corresponding regions on MR images and histologic specimens
      were defined by using anatomically defined segments in peripheral zone (PZ) and
      central gland tissue. Cancer and normal PZ regions were identified at
      histopathologic analysis. Each MR parameter-histologic tissue component pair was 
      assessed by using linear mixed-effects models, and cancer versus normal PZ values
      were compared by using nonparametric tests. RESULTS: ADC and T2 were inversely
      related to percentage area of nuclei and percentage area of cytoplasm and
      positively related to percentage area of luminal space (P < or = .01). These
      trends were reversed for K(trans) (P < .001). K(trans) had a significantly
      negative (P = .01) slope versus percentage area of stroma, and v(e) had a
      positive (P = .008) slope versus percentage area of stroma. The v(e) was
      inversely proportional to the percentage area of nuclei (P = .05). All MR imaging
      parameters (P < or = .05) and the percentage areas of all tissue components (P < 
      or = .001) except stroma (P > .48) were significantly different between cancer
      and normal PZ tissue. CONCLUSION: MR imaging-derived parameters measured in the
      prostate were significantly related to the proportion of specific histologic
      components that differ between normal and malignant PZ tissue. These
      relationships may help define imaging-related histologic prognostic parameters
      for prostate cancer.
FAU - Langer, Deanna L
AU  - Langer DL
AD  - Department of Medical Imaging, Princess Margaret Hospital, University Health
      Network and Mount Sinai Hospital, 610 University Ave, Room 3-958, Toronto, ON,
      Canada M5G 2M9.
FAU - van der Kwast, Theodorus H
AU  - van der Kwast TH
FAU - Evans, Andrew J
AU  - Evans AJ
FAU - Plotkin, Anna
AU  - Plotkin A
FAU - Trachtenberg, John
AU  - Trachtenberg J
FAU - Wilson, Brian C
AU  - Wilson BC
FAU - Haider, Masoom A
AU  - Haider MA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adult
MH  - Aged
MH  - Diffusion Magnetic Resonance Imaging/*methods
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Prostate/*pathology/surgery
MH  - Prostatectomy
MH  - Prostatic Neoplasms/*pathology/surgery
MH  - Staining and Labeling
MH  - Statistics, Nonparametric
EDAT- 2010/04/24 06:00
MHDA- 2010/05/25 06:00
CRDT- 2010/04/24 06:00
PHST- 2010/04/24 06:00 [entrez]
PHST- 2010/04/24 06:00 [pubmed]
PHST- 2010/05/25 06:00 [medline]
AID - 255/2/485 [pii]
AID - 10.1148/radiol.10091343 [doi]
PST - ppublish
SO  - Radiology. 2010 May;255(2):485-94. doi: 10.1148/radiol.10091343.


PMID- 20413713
OWN - NLM
STAT- MEDLINE
DCOM- 20100715
LR  - 20100423
IS  - 1552-5732 (Electronic)
IS  - 0890-3344 (Linking)
VI  - 26
IP  - 2
DP  - 2010 May
TI  - Lactation and breastfeeding research studies: who should provide consent for the 
      neonate?
PG  - 180-2
LID - 10.1177/0890334410365068 [doi]
AB  - Research ethics guidelines do not provide sufficient direction for breastfeeding 
      and human lactation studies. This article presents the principles of consent for 
      research studies and discusses rationales for who should consent for infants in
      lactation and breastfeeding research studies.
FAU - Noel-Weiss, Joy
AU  - Noel-Weiss J
AD  - University of Ottawa School of Nursing, Ottawa, Ontario, Canada.
      Joy.Noel-Weiss@uottawa.ca
FAU - Woodend, A Kirsten
AU  - Woodend AK
FAU - Kujawa-Myles, Sonya
AU  - Kujawa-Myles S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Hum Lact
JT  - Journal of human lactation : official journal of International Lactation
      Consultant Association
JID - 8709498
MH  - Adult
MH  - *Breast Feeding
MH  - *Ethics, Research
MH  - Female
MH  - Guidelines as Topic
MH  - Humans
MH  - Infant, Newborn
MH  - Informed Consent/*ethics
MH  - Male
MH  - Parents/psychology
EDAT- 2010/04/24 06:00
MHDA- 2010/07/16 06:00
CRDT- 2010/04/24 06:00
PHST- 2010/04/24 06:00 [entrez]
PHST- 2010/04/24 06:00 [pubmed]
PHST- 2010/07/16 06:00 [medline]
AID - 26/2/180 [pii]
AID - 10.1177/0890334410365068 [doi]
PST - ppublish
SO  - J Hum Lact. 2010 May;26(2):180-2. doi: 10.1177/0890334410365068.


PMID- 20413578
OWN - NLM
STAT- MEDLINE
DCOM- 20100715
LR  - 20111117
IS  - 1538-6724 (Electronic)
IS  - 0031-9023 (Linking)
VI  - 90
IP  - 6
DP  - 2010 Jun
TI  - Constrained physical therapist practice: an ethical case analysis of recommending
      discharge placement from the acute care setting.
PG  - 939-52
LID - 10.2522/ptj.20050399 [doi]
AB  - BACKGROUND AND PURPOSE: Constrained practice is routinely encountered by physical
      therapists and may limit the physical therapist's primary moral
      responsibility-which is to help the patient to become well again. Ethical
      practice under such conditions requires a certain moral character of the
      practitioner. The purposes of this article are: (1) to provide an ethical
      analysis of a typical patient case of constrained clinical practice, (2) to
      discuss the moral implications of constrained clinical practice, and (3) to
      identify key moral principles and virtues fostering ethical physical therapist
      practice. CASE: The case represents a common scenario of discharge planning in
      acute care health facilities in the northeastern United States. METHODS: An
      applied ethics approach was used for case analysis. RESULTS: The decision
      following analysis of the dilemma was to provide the needed care to the patient
      as required by compassion, professional ethical standards, and organizational
      mission. DISCUSSION AND CONCLUSION: Constrained clinical practice creates a moral
      dilemma for physical therapists. Being responsive to the patient's needs moves
      the physical therapist's practice toward the professional ideal of helping
      vulnerable patients become well again. Meeting the patient's needs is a
      professional requirement of the physical therapist as moral agent. Acting
      otherwise requires an alternative position be ethically justified based on
      systematic analysis of a particular case. Skepticism of status quo practices is
      required to modify conventional individual, organizational, and societal
      practices toward meeting the patient's best interest.
FAU - Nalette, Ernest
AU  - Nalette E
AD  - Department of Physical Therapy, Ithaca College, Rochester, New York. Mailing
      address: 1100 S Goodman St, Rochester, NY 14620, USA. enalette@ithaca.edu
LA  - eng
PT  - Journal Article
DEP - 20100422
PL  - United States
TA  - Phys Ther
JT  - Physical therapy
JID - 0022623
SB  - IM
MH  - Decision Making
MH  - *Ethical Analysis
MH  - *Ethics, Professional
MH  - Health Services Needs and Demand
MH  - Humans
MH  - Morals
MH  - *Patient Discharge
MH  - Physical Therapy Specialty/*ethics
MH  - Rehabilitation Centers
EDAT- 2010/04/24 06:00
MHDA- 2010/07/16 06:00
CRDT- 2010/04/24 06:00
PHST- 2010/04/24 06:00 [entrez]
PHST- 2010/04/24 06:00 [pubmed]
PHST- 2010/07/16 06:00 [medline]
AID - ptj.20050399 [pii]
AID - 10.2522/ptj.20050399 [doi]
PST - ppublish
SO  - Phys Ther. 2010 Jun;90(6):939-52. doi: 10.2522/ptj.20050399. Epub 2010 Apr 22.


PMID- 20413224
OWN - NLM
STAT- MEDLINE
DCOM- 20110412
LR  - 20101001
IS  - 1879-1409 (Electronic)
IS  - 0305-4179 (Linking)
VI  - 36
IP  - 7
DP  - 2010 Nov
TI  - Clinical considerations in face transplantation.
PG  - 951-8
LID - 10.1016/j.burns.2010.01.011 [doi]
AB  - Severe facial burns cause significant deformities that are technically
      challenging to treat. Conventional treatments almost always result in poor
      aesthetic and functional outcomes. This is due to the fact that current
      treatments cover or replace the delicate anatomical facial tissues with autologus
      grafts and flaps from remote sites. The recent introduction of clinical composite
      tissue allotransplantation (CTA) that uses healthy facial tissue transplanted
      from donors to reconstruct the damaged or non-existing facial tissues with
      original tissues makes it possible to achieve the best possible functional and
      aesthetic outcomes in these challenging injuries. The techniques required to
      perform this procedure, while technically challenging, have been developed over
      many years and are used routinely in reconstructive surgery. The
      immunosuppressive regimens necessary to prevent transplanted facial tissue from
      rejecting (tacrolimus/mycophenolate mofetil/steroid) were developed for and have 
      been used successfully in solid organ transplants for many years. The
      psychosocial and ethical issues associated with this new treatment have some
      nuances but generally have many similarities with solid organ and more recently
      hand transplantation, both of which have been performed clinically for 40 and 10+
      years respectively. Herein, we will discuss the technical and immunological
      aspects of facial tissue transplantation. The psychosocial and ethical issues
      will be discussed separately in another article in this issue.
CI  - Copyright (c) 2010 Elsevier Ltd and ISBI. All rights reserved.
FAU - Pushpakumar, Sathnur B
AU  - Pushpakumar SB
AD  - Department of Surgery, University of Louisville, KY, USA.
FAU - Barker, John H
AU  - Barker JH
FAU - Soni, Chirag V
AU  - Soni CV
FAU - Joseph, Hazel
AU  - Joseph H
FAU - van Aalst, Vera C
AU  - van Aalst VC
FAU - Banis, Joseph C
AU  - Banis JC
FAU - Frank, Johannes
AU  - Frank J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100421
PL  - Netherlands
TA  - Burns
JT  - Burns : journal of the International Society for Burn Injuries
JID - 8913178
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Burns/*surgery
MH  - Facial Transplantation/*methods
MH  - Graft Rejection
MH  - Humans
MH  - Immunosuppressive Agents/therapeutic use
MH  - Patient Selection
MH  - Reconstructive Surgical Procedures/*methods
MH  - Skin Transplantation/methods
MH  - Tissue and Organ Procurement
MH  - Transplantation, Homologous
EDAT- 2010/04/24 06:00
MHDA- 2011/04/13 06:00
CRDT- 2010/04/24 06:00
PHST- 2009/10/28 00:00 [received]
PHST- 2010/01/14 00:00 [accepted]
PHST- 2010/04/24 06:00 [entrez]
PHST- 2010/04/24 06:00 [pubmed]
PHST- 2011/04/13 06:00 [medline]
AID - S0305-4179(10)00025-2 [pii]
AID - 10.1016/j.burns.2010.01.011 [doi]
PST - ppublish
SO  - Burns. 2010 Nov;36(7):951-8. doi: 10.1016/j.burns.2010.01.011. Epub 2010 Apr 21.


PMID- 20413212
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20100531
IS  - 1095-8630 (Electronic)
IS  - 0301-4797 (Linking)
VI  - 91
IP  - 8
DP  - 2010 Aug
TI  - Embedded value systems in sustainability assessment tools and their implications.
PG  - 1613-22
LID - 10.1016/j.jenvman.2010.03.014 [doi]
AB  - This paper explores the implications that arise with the selection of specific
      sustainability evaluation tools. Sustainability evaluation tools are
      conceptualized in this paper as value articulating institutions and as such their
      choice is a far from a trivial matter. In fact their choice can entail various
      ethical and practical repercussions. However, in most cases the choice of the
      evaluation tool is made by the analyst(s) without taking into consideration the
      values of the affected stakeholders. By choosing the analytical tool the analyst 
      essentially "subscribes to" and ultimately "enforces" a particular worldview as
      the legitimate yardstick to evaluate the sustainability of a particular project
      (or policy). Instead, this paper argues that the selection of evaluation tools
      should be consistent with the values of the affected stakeholders. With this in
      mind, different sustainability evaluation tools' assumptions are critically
      reviewed and a number of suggestions that could facilitate the choice of the most
      appropriate tool according to the context of the sustainability evaluation are
      provided. It is expected that conscious evaluation tool selection, following the 
      suggestions made in this paper, will reduce the risk of providing distorted
      sustainability evaluations.
CI  - Copyright 2010 Elsevier Ltd. All rights reserved.
FAU - Gasparatos, Alexandros
AU  - Gasparatos A
AD  - Institute of Advanced Studies, United Nations University, 1-1-1 Minato Mirai,
      Nishi-ku 220-8502, Yokohama, Japan. gasparatos@ias.unu.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100422
PL  - England
TA  - J Environ Manage
JT  - Journal of environmental management
JID - 0401664
SB  - IM
MH  - *Conservation of Natural Resources
MH  - Cost-Benefit Analysis
MH  - Decision Making
MH  - *Decision Support Techniques
MH  - Ecology
MH  - Environment
MH  - Environmental Health/*methods
MH  - Humans
MH  - Program Evaluation/*methods
MH  - Risk Assessment/*methods
MH  - United States
MH  - United States Environmental Protection Agency
EDAT- 2010/04/24 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/04/24 06:00
PHST- 2009/09/16 00:00 [received]
PHST- 2010/03/04 00:00 [revised]
PHST- 2010/03/23 00:00 [accepted]
PHST- 2010/04/24 06:00 [entrez]
PHST- 2010/04/24 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - S0301-4797(10)00086-1 [pii]
AID - 10.1016/j.jenvman.2010.03.014 [doi]
PST - ppublish
SO  - J Environ Manage. 2010 Aug;91(8):1613-22. doi: 10.1016/j.jenvman.2010.03.014.
      Epub 2010 Apr 22.


PMID- 20412986
OWN - NLM
STAT- MEDLINE
DCOM- 20100721
LR  - 20100423
IS  - 1872-7603 (Electronic)
IS  - 0165-0378 (Linking)
VI  - 85
IP  - 1
DP  - 2010 May
TI  - The ethics of assisted reproduction.
PG  - 3-8
LID - 10.1016/j.jri.2010.02.001 [doi]
AB  - Issues concerning the beginning of life and medical intervention in the onset of 
      human existence are very delicate in their nature; they involve multi-dimensional
      knowledge, they are difficult to comprehend and sensitive to handle. When pure
      scientific elements are combined with profound emotions, when the genius of
      technological discoveries touches upon human dignity and sanctity, when passion
      for the technological achievement intervenes in basic human rights, then the
      sense of inadequacy and ignorance becomes intense and critical. Silence seems
      more sought-after than words, and willingness to learn more prudent than the
      desire to speak. Fear of the inconceivable consequences and even more so the
      inability to assess them, experiments with the unknown, the likelihood that basic
      historical, ethical and social values may change forever, but mainly the
      replacement of God in His wondrous work of creation--the onset of human
      life--places the ethics of reproductive technologies on the frontline of
      contemporary bioethics. This opinion paper does not deal with dangers, insults,
      fears, threats, "speed limits" or ethical controversies, but rather with the very
      mystery of life. Although there are no generally accepted replies to the various 
      questions being posed, some thoughts and reservations, which can shed some light 
      upon complicated dilemmas are presented. Firstly, the content of reproductive
      technologies, the problem of infertility today, the methods of fertility
      treatment, and of prenatal and pre-implantation testing are described, and then
      the social impact of IVF, complicated cases, deontological dilemmas and some
      ethical concerns are discussed.
CI  - Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Chatzinikolaou, Nikolaos
AU  - Chatzinikolaou N
AD  - infocenter@imml.gr
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Ireland
TA  - J Reprod Immunol
JT  - Journal of reproductive immunology
JID - 8001906
SB  - IM
MH  - Female
MH  - Humans
MH  - Pregnancy
MH  - Reproductive Techniques, Assisted/*ethics
RF  - 19
EDAT- 2010/04/24 06:00
MHDA- 2010/07/22 06:00
CRDT- 2010/04/24 06:00
PHST- 2010/01/14 00:00 [received]
PHST- 2010/02/05 00:00 [revised]
PHST- 2010/02/11 00:00 [accepted]
PHST- 2010/04/24 06:00 [entrez]
PHST- 2010/04/24 06:00 [pubmed]
PHST- 2010/07/22 06:00 [medline]
AID - S0165-0378(10)00033-1 [pii]
AID - 10.1016/j.jri.2010.02.001 [doi]
PST - ppublish
SO  - J Reprod Immunol. 2010 May;85(1):3-8. doi: 10.1016/j.jri.2010.02.001.


PMID- 20412797
OWN - NLM
STAT- MEDLINE
DCOM- 20100824
LR  - 20100803
IS  - 1090-2449 (Electronic)
IS  - 0014-4894 (Linking)
VI  - 126
IP  - 2
DP  - 2010 Oct
TI  - Precision-cut hamster liver slices as an ex vivo model to study amoebic liver
      abscess.
PG  - 117-25
LID - 10.1016/j.exppara.2010.04.005 [doi]
AB  - Entamoeba histolytica is the etiological agent of amoebiasis, the second cause of
      global morbidity and mortality due to parasitic diseases in humans. In
      approximately 1% of the cases, amoebas penetrate the intestinal mucosa and spread
      to other organs, producing extra-intestinal lesions, among which amoebic liver
      abscess (ALA) is the most common. To study ALA, in vivo and in vitro models are
      used. However, animal models may pose ethical issues, and are time-consuming and 
      costly; and cell cultures represent isolated cellular lineages. The present study
      reports the infection of precision-cut hamster liver slices with Entamoeba
      histolytica trophozoites. The infection time-course, including tissue damage,
      parallels findings previously reported in the animal model. At the same time
      amoebic virulence factors were detected in the infected slices. This new model to
      study ALA is simple and reproducible, and employs less than 1/3 of the hamsters
      required for in vivo analyses.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Carranza-Rosales, Pilar
AU  - Carranza-Rosales P
AD  - Division de Biologia Celular y Molecular, Centro de Investigacion Biomedica del
      Noreste, Instituto Mexicano del Seguro Social, Administracion de Correos No. 4,
      Apartado Postal 020, Colonia Independencia, Monterrey, NL, CP 64720, Mexico.
      pilarcarranza@cibinmty.net
FAU - Santiago-Mauricio, Maria Guadalupe
AU  - Santiago-Mauricio MG
FAU - Guzman-Delgado, Nancy Elena
AU  - Guzman-Delgado NE
FAU - Vargas-Villarreal, Javier
AU  - Vargas-Villarreal J
FAU - Lozano-Garza, Gerardo
AU  - Lozano-Garza G
FAU - Ventura-Juarez, Javier
AU  - Ventura-Juarez J
FAU - Balderas-Renteria, Isaias
AU  - Balderas-Renteria I
FAU - Moran-Martinez, Javier
AU  - Moran-Martinez J
FAU - Gandolfi, A Jay
AU  - Gandolfi AJ
LA  - eng
PT  - Journal Article
DEP - 20100420
PL  - United States
TA  - Exp Parasitol
JT  - Experimental parasitology
JID - 0370713
RN  - 0 (Actins)
RN  - 0 (DNA, Complementary)
RN  - 0 (Ion Channels)
RN  - 0 (Protozoan Proteins)
RN  - 0 (RNA, Protozoan)
RN  - 0 (Virulence Factors)
RN  - 0 (amoebapore proteins, protozoan)
RN  - EC 3.4.- (Cysteine Proteases)
SB  - IM
MH  - Actins/analysis/genetics
MH  - Animals
MH  - Cricetinae
MH  - Cysteine Proteases/analysis/genetics
MH  - DNA, Complementary/analysis
MH  - *Disease Models, Animal
MH  - Entamoeba histolytica/genetics/*pathogenicity
MH  - Ion Channels/analysis/genetics
MH  - Liver/*parasitology
MH  - Liver Abscess, Amebic/*parasitology/pathology
MH  - Male
MH  - Mesocricetus
MH  - Polymerase Chain Reaction
MH  - Protozoan Proteins/analysis/genetics
MH  - RNA, Protozoan/genetics/isolation & purification
MH  - Tissue Culture Techniques
MH  - Virulence
MH  - Virulence Factors/*analysis/genetics
EDAT- 2010/04/24 06:00
MHDA- 2010/08/25 06:00
CRDT- 2010/04/24 06:00
PHST- 2010/01/07 00:00 [received]
PHST- 2010/03/22 00:00 [revised]
PHST- 2010/04/12 00:00 [accepted]
PHST- 2010/04/24 06:00 [entrez]
PHST- 2010/04/24 06:00 [pubmed]
PHST- 2010/08/25 06:00 [medline]
AID - S0014-4894(10)00111-6 [pii]
AID - 10.1016/j.exppara.2010.04.005 [doi]
PST - ppublish
SO  - Exp Parasitol. 2010 Oct;126(2):117-25. doi: 10.1016/j.exppara.2010.04.005. Epub
      2010 Apr 20.


PMID- 20412562
OWN - NLM
STAT- MEDLINE
DCOM- 20100726
LR  - 20211028
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 11
DP  - 2010 Apr 22
TI  - A systematic review of clinical trials of pharmacological interventions for acute
      ischaemic stroke (1955-2008) that were completed, but not published in full.
PG  - 43
LID - 10.1186/1745-6215-11-43 [doi]
AB  - BACKGROUND: We assessed the prevalence, and potential impact of, trials of
      pharmacological agents for acute stroke that were completed but not published in 
      full. Failure to publish trial data is to be deprecated as it sets aside the
      altruism of participants' consent to be exposed to the risks of experimental
      interventions, potentially biases the assessment of the effects of therapies, and
      may lead to premature discontinuation of research into promising treatments.
      METHODS: We searched the Cochrane Stroke Group's Specialised Register of Trials
      in June 2008 for completed trials of pharmacological interventions for acute
      ischaemic stroke, and searched MEDLINE and EMBASE (January 2007 - March 2009) for
      references to recent full publications. We assessed trial completion status from 
      trial reports, online trials registers and correspondence with experts. RESULTS: 
      We identified 940 trials. Of these, 125 (19.6%, 95% confidence interval
      16.5-22.6) were completed but not published in full by the point prevalence date.
      They included 16,058 participants (16 trials had over 300 participants each) and 
      tested 89 different interventions. Twenty-two trials with a total of 4,251
      participants reported the number of deaths. In these trials, 636/4251 (15.0%)
      died. CONCLUSIONS: Our data suggest that, at the point prevalence date, a
      substantial body of evidence that was of relevance both to clinical practice in
      acute stroke and future research in the field was not published in full. Over
      16,000 patients had given informed consent and were exposed to the risks of
      therapy. Responsibility for non-publication lies with investigators, but
      pharmaceutical companies, research ethics committees, journals and governments
      can all encourage the timely publication of trial data.
FAU - Gibson, Lorna M
AU  - Gibson LM
AD  - Department of Clinical Neurosciences, University of Edinburgh, Western General
      Hospital, Edinburgh, UK.
FAU - Brazzelli, Miriam
AU  - Brazzelli M
FAU - Thomas, Brenda M
AU  - Thomas BM
FAU - Sandercock, Peter A G
AU  - Sandercock PA
LA  - eng
GR  - G0800803/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20100422
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
RN  - 0 (Cardiovascular Agents)
SB  - IM
MH  - Brain Ischemia/complications/*drug therapy
MH  - Cardiovascular Agents/adverse effects/*therapeutic use
MH  - Clinical Trials as Topic
MH  - Evidence-Based Medicine
MH  - Humans
MH  - Information Dissemination
MH  - Informed Consent
MH  - Publishing
MH  - Risk Assessment
MH  - Stroke/*drug therapy/etiology
MH  - Treatment Outcome
RF  - 147
PMC - PMC2873274
EDAT- 2010/04/24 06:00
MHDA- 2010/07/27 06:00
CRDT- 2010/04/24 06:00
PHST- 2009/04/29 00:00 [received]
PHST- 2010/04/22 00:00 [accepted]
PHST- 2010/04/24 06:00 [entrez]
PHST- 2010/04/24 06:00 [pubmed]
PHST- 2010/07/27 06:00 [medline]
AID - 1745-6215-11-43 [pii]
AID - 10.1186/1745-6215-11-43 [doi]
PST - epublish
SO  - Trials. 2010 Apr 22;11:43. doi: 10.1186/1745-6215-11-43.


PMID- 20411874
OWN - NLM
STAT- MEDLINE
DCOM- 20100726
LR  - 20191210
IS  - 0022-0124 (Print)
IS  - 0022-0124 (Linking)
VI  - 41
IP  - 6
DP  - 2010 Jun
TI  - Twelve important minutes: introducing enhanced online materials about elder abuse
      to nursing assistants.
PG  - 281-8
LID - 10.3928/00220124-20100401-08 [doi]
AB  - A pilot project introduced 12 minutes of text and video materials and a
      reflective online interaction about elder abuse into the online component of a
      hybrid course in nursing assistant training leading to certification. Didactic
      presentations on issues of ethics and standards had been given in two different
      units of the face-to-face component of the course using both the course textbook 
      and an online module keyed to state certification standards. However, student
      responses suggested that their online writing to each other about the new
      materials brought issues of elder abuse to the forefront in ways that they could 
      finally internalize.
FAU - Smith, Mary K
AU  - Smith MK
AD  - Healthcare Continuing Education, Central Piedmont Community College, Charlotte,
      NC 28235, USA.
FAU - Davis, Boyd H
AU  - Davis BH
FAU - Blowers, Anita
AU  - Blowers A
FAU - Shenk, Dena
AU  - Shenk D
FAU - Jackson, Kina
AU  - Jackson K
FAU - Kalaw, Karel
AU  - Kalaw K
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - United States
TA  - J Contin Educ Nurs
JT  - Journal of continuing education in nursing
JID - 0262321
MH  - Aged
MH  - Attitude of Health Personnel
MH  - Blogging
MH  - Certification
MH  - Computer-Assisted Instruction/*methods
MH  - Curriculum
MH  - Education, Nursing, Continuing/*methods
MH  - Elder Abuse/*prevention & control
MH  - Humans
MH  - North Carolina
MH  - Nursing Assistants/*education/psychology
MH  - Nursing Education Research
MH  - Pilot Projects
MH  - Practice Guidelines as Topic
MH  - Program Evaluation
MH  - User-Computer Interface
EDAT- 2010/04/24 06:00
MHDA- 2010/07/27 06:00
CRDT- 2010/04/24 06:00
PHST- 2010/04/24 06:00 [entrez]
PHST- 2010/04/24 06:00 [pubmed]
PHST- 2010/07/27 06:00 [medline]
AID - 10.3928/00220124-20100401-08 [doi]
PST - ppublish
SO  - J Contin Educ Nurs. 2010 Jun;41(6):281-8. doi: 10.3928/00220124-20100401-08.


PMID- 20411865
OWN - NLM
STAT- MEDLINE
DCOM- 20101021
LR  - 20101004
IS  - 0148-4834 (Print)
IS  - 0148-4834 (Linking)
VI  - 49
IP  - 6
DP  - 2010 Jun
TI  - Contesting our taken-for-granted understanding of student evaluation: insights
      from a team of institutional ethnographers.
PG  - 333-9
LID - 10.3928/01484834-20100331-01 [doi]
AB  - Educating for nursing excellence can be demanding and challenging work. One of
      the troubling centers of attention for nurse educators is their evaluation of
      nursing students in practice. This article outlines some of the problems nurse
      educators encounter in evaluation work and uses the theoretical framework of
      institutional ethnography to disrupt some of the conventional explanations that
      mediate what happens in teaching and evaluation work when students fail to meet
      the required standards. In developing our analysis, we describe our research
      process and provide details about how we used some of the methodological
      conventions of institutional ethnography. The early findings from this project
      provide an alternate knowledge of our evaluation practices, which demands that we
      question our taken-for-granted understanding of due process and what it is
      accomplishing. Our findings raise compelling ethical questions that guide nurse
      educators to rethink our evaluation work.
CI  - Copyright 2010, SLACK Incorporated.
FAU - Rankin, Janet M
AU  - Rankin JM
AD  - University of Calgary, Alberta, Canada. jmrankin@ucalgary.ca
FAU - Malinsky, Lynn
AU  - Malinsky L
FAU - Tate, Betty
AU  - Tate B
FAU - Elena, Linda
AU  - Elena L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100603
PL  - United States
TA  - J Nurs Educ
JT  - The Journal of nursing education
JID - 7705432
SB  - IM
MH  - Anthropology, Cultural/*organization & administration
MH  - *Attitude of Health Personnel
MH  - Clinical Competence
MH  - Education, Nursing, Baccalaureate/*organization & administration
MH  - *Educational Measurement/methods
MH  - Faculty, Nursing/*organization & administration
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Interprofessional Relations
MH  - Models, Educational
MH  - Models, Nursing
MH  - Nurse's Role/psychology
MH  - Nursing Education Research
MH  - Nursing Methodology Research
MH  - Philosophy, Nursing
MH  - Prejudice
MH  - Research Design
MH  - Research Personnel/education/organization & administration/*psychology
MH  - Students, Nursing/psychology
MH  - Thinking
EDAT- 2010/04/24 06:00
MHDA- 2010/10/22 06:00
CRDT- 2010/04/24 06:00
PHST- 2009/02/09 00:00 [received]
PHST- 2009/10/25 00:00 [accepted]
PHST- 2010/04/24 06:00 [entrez]
PHST- 2010/04/24 06:00 [pubmed]
PHST- 2010/10/22 06:00 [medline]
AID - 10.3928/01484834-20100331-01 [doi]
PST - ppublish
SO  - J Nurs Educ. 2010 Jun;49(6):333-9. doi: 10.3928/01484834-20100331-01. Epub 2010
      Jun 3.


PMID- 20411449
OWN - NLM
STAT- MEDLINE
DCOM- 20100713
LR  - 20151119
IS  - 0022-9032 (Print)
IS  - 0022-9032 (Linking)
VI  - 68
IP  - 3
DP  - 2010 Mar
TI  - Determinants of mortality in patients requiring prolonged intensive care unit
      stay after elective isolated on-pump coronary artery bypass grafting surgery.
PG  - 257-62
AB  - BACKGROUND: In up to 36% of patients undergoing cardiac surgery prolonged
      intensive care unit stay may be necessary. Mortality rates of these patients
      range from 11% to 94%, causing enormous clinical and ethical issues. AIM: To
      identify preoperative, perioperative and postoperative risk factors of mortality 
      in patients with prolonged intensive care unit stay after elective, isolated
      on-pump coronary artery bypass grafting surgery. METHODS: Clinical data of 137
      patients who underwent an elective, isolated on-pump coronary artery bypass
      grafting operation, and had an intensive care unit stay of > or = 3 days were
      retrospectively evaluated. Survivors and non-survivors were compared with regard 
      to preoperative, perioperative and postoperative characteristics to identify the 
      risk factors for mortality. RESULTS: Multivariate analysis demonstrated that
      diabetes mellitus (OR = 3.62, 95% CI 1.07-12.26, p = 0.039), postoperative renal 
      dysfunction (OR = 3.86, 95% CI 1.26-11.75, p = 0.018), postoperative intra-aortic
      balloon pump use (OR = 3.47; 95% CI 1.01-13.24, p = 0.048), prolonged intubation 
      (OR = 3.90, 95% CI 1.19-12.69, p = 0.024) and re-intubation (OR = 14.83, 95% CI
      4.35-50.55, p = 0.001) were significant and independent risk factors of
      mortality. CONCLUSION: The present study found that the preoperative presence of 
      diabetes mellitus, and postoperative multiorgan failure syndrome decreased the
      probability of survival in patients with prolonged intensive care unit stay after
      elective isolated on-pump coronary artery bypass surgery.
FAU - Tekumit, Hayrettin
AU  - Tekumit H
AD  - Ozel Avrupa Safak Hastanesi, Kucukkoy yolu hamam sok., Turkey. htekumit@yahoo.com
FAU - Uzun, Kemal
AU  - Uzun K
FAU - Cenal, Ali Riza
AU  - Cenal AR
FAU - Tataroglu, Cenk
AU  - Tataroglu C
FAU - Polat, Adil
AU  - Polat A
FAU - Akinci, Esat
AU  - Akinci E
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - Kardiol Pol
JT  - Kardiologia polska
JID - 0376352
SB  - IM
CIN - Kardiol Pol. 2010 Mar;68(3):263-4. PMID: 20491176
MH  - Aged
MH  - Causality
MH  - Comorbidity
MH  - Coronary Artery Bypass/*mortality
MH  - Critical Care/*statistics & numerical data
MH  - Diabetes Mellitus/epidemiology
MH  - Elective Surgical Procedures/*mortality
MH  - Female
MH  - Humans
MH  - Intubation, Intratracheal/statistics & numerical data
MH  - Kidney Diseases/epidemiology
MH  - Length of Stay/*statistics & numerical data
MH  - Male
MH  - Middle Aged
MH  - Multiple Organ Failure/epidemiology
MH  - Multivariate Analysis
MH  - Postoperative Complications/epidemiology
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Survival Rate
MH  - Turkey/epidemiology
EDAT- 2010/04/23 06:00
MHDA- 2010/07/14 06:00
CRDT- 2010/04/23 06:00
PHST- 2010/04/23 06:00 [entrez]
PHST- 2010/04/23 06:00 [pubmed]
PHST- 2010/07/14 06:00 [medline]
PST - ppublish
SO  - Kardiol Pol. 2010 Mar;68(3):257-62.


PMID- 20411443
OWN - NLM
STAT- MEDLINE
DCOM- 20110120
LR  - 20220311
IS  - 1532-4796 (Electronic)
IS  - 0883-6612 (Linking)
VI  - 40
IP  - 1
DP  - 2010 Aug
TI  - Recruitment for an internet-based diabetes self-management program: scientific
      and ethical implications.
PG  - 40-8
LID - 10.1007/s12160-010-9189-1 [doi]
AB  - BACKGROUND: Little is known about the reach of Internet self-management
      interventions. PURPOSE: The aim of this study was to evaluate different
      definitions of participation rate and compare characteristics among subcategories
      of participants and nonparticipants on demographic and clinical factors using
      de-identified electronic medical record data. METHODS: Data are presented on
      recruitment results and characteristics of 2,603 health maintenance organization 
      members having type 2 diabetes invited to participate in an Internet
      self-management program. RESULTS: There was a 37% participation rate among all
      members attempted to contact and presumed eligible. There were several
      significant differences between participants and nonparticipants and among
      subgroups of participants (e.g., proactive volunteers vs. telephone respondents) 
      on factors including age, income, ethnicity, smoking rate, education, blood
      pressure, and hemoglobin A1c. CONCLUSION: These results have important
      implications for the impact of different recruitment methods on health
      disparities and generalization of results. We provide recommendations for
      reporting of eligibility rate, participation rate, and representativeness
      analyses.
FAU - Glasgow, Russell E
AU  - Glasgow RE
AD  - Institute for Health Research, Kaiser Permanente Colorado, PO Box 378066, Denver,
      CO, 80237-8066, USA. russg@re-aim.net
FAU - Strycker, Lisa A
AU  - Strycker LA
FAU - Kurz, Deanna
AU  - Kurz D
FAU - Faber, Andrew
AU  - Faber A
FAU - Bell, Hillary
AU  - Bell H
FAU - Dickman, Jennifer M
AU  - Dickman JM
FAU - Halterman, Eve
AU  - Halterman E
FAU - Estabrooks, Paul A
AU  - Estabrooks PA
FAU - Osuna, Diego
AU  - Osuna D
LA  - eng
GR  - R37 DK035524/DK/NIDDK NIH HHS/United States
GR  - 2 R01 DK035524-21/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - Ann Behav Med
JT  - Annals of behavioral medicine : a publication of the Society of Behavioral
      Medicine
JID - 8510246
SB  - IM
MH  - Adult
MH  - Aged
MH  - Diabetes Mellitus, Type 2/*psychology/therapy
MH  - Female
MH  - Humans
MH  - Internet
MH  - Male
MH  - Middle Aged
MH  - Patient Acceptance of Health Care/*psychology
MH  - Patient Selection/*ethics
MH  - Self Care/*methods
MH  - Therapy, Computer-Assisted/*methods
EDAT- 2010/04/23 06:00
MHDA- 2011/01/21 06:00
CRDT- 2010/04/23 06:00
PHST- 2010/04/23 06:00 [entrez]
PHST- 2010/04/23 06:00 [pubmed]
PHST- 2011/01/21 06:00 [medline]
AID - 10.1007/s12160-010-9189-1 [doi]
PST - ppublish
SO  - Ann Behav Med. 2010 Aug;40(1):40-8. doi: 10.1007/s12160-010-9189-1.


PMID- 20411339
OWN - NLM
STAT- MEDLINE
DCOM- 20110128
LR  - 20211020
IS  - 1572-8633 (Electronic)
IS  - 1386-7423 (Linking)
VI  - 13
IP  - 4
DP  - 2010 Nov
TI  - The diseased embodied mind: constructing a conception of mental disease in
      relation to the person.
PG  - 321-32
LID - 10.1007/s11019-010-9246-3 [doi]
AB  - Without a better understanding of mental disease, patients diagnosed with a
      mental disease may be mistreated clinically and/or socially, and caregivers and
      families may be wrongfully blamed for causing the disease and/or for not
      effectively helping and developing meaningful relationships with the patient as
      person. In trying to understand mental disease and why its various dimensions
      raise difficulties for our systems of classification and our medical models of
      diagnosis and treatment, a framework is required. This framework will connect
      metaphysical, epistemological, and ethical considerations in ways that are
      mutually supportive and illuminating. This, in turn, will benefit those who are
      diseased and those persons who study, classify, diagnose, and treat disease.
FAU - Aultman, Julie M
AU  - Aultman JM
AD  - Department of Behavioral and Community Health Sciences, Northeastern Ohio
      Universities College of Medicine, 4209 State Route 44, Rootstown, OH 44272, USA. 
      jmaultma@neoucom.edu
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Med Health Care Philos
JT  - Medicine, health care, and philosophy
JID - 9815900
SB  - IM
MH  - Autistic Disorder
MH  - Humans
MH  - *Mental Disorders/classification
MH  - *Mind-Body Relations, Metaphysical
MH  - *Personhood
MH  - *Philosophy, Medical
MH  - Psychiatry/*ethics
EDAT- 2010/04/23 06:00
MHDA- 2011/02/01 06:00
CRDT- 2010/04/23 06:00
PHST- 2010/04/23 06:00 [entrez]
PHST- 2010/04/23 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
AID - 10.1007/s11019-010-9246-3 [doi]
PST - ppublish
SO  - Med Health Care Philos. 2010 Nov;13(4):321-32. doi: 10.1007/s11019-010-9246-3.


PMID- 20411338
OWN - NLM
STAT- MEDLINE
DCOM- 20101220
LR  - 20100812
IS  - 1572-8633 (Electronic)
IS  - 1386-7423 (Linking)
VI  - 13
IP  - 3
DP  - 2010 Aug
TI  - Human dignity and human rights in bioethics: the Kantian approach.
PG  - 251-7
LID - 10.1007/s11019-010-9249-0 [doi]
AB  - The concept of human dignity plays an important role in the public discussion
      about ethical questions concerning modern medicine and biology. At the same time,
      there is a widespread skepticism about the possibility to determine the content
      and the claims of human dignity. The article goes back to Kantian Moral
      Philosophy, in order to show that human dignity has in fact a determinable
      content not as a norm in itself, but as the principle and ground of human rights 
      and any deontological norms in biomedical ethics. When it comes to defining the
      scope of human dignity, i.e., the question which entities are protected by human 
      dignity, Kant clearly can be found on the "pro life"-side of the controversy.
      This, however, is the result of some specific implications of Kant's
      transcendental approach that may be put into question.
FAU - Rothhaar, Markus
AU  - Rothhaar M
AD  - Center for Interdisciplinary Research, Bielefeld University, Wellenberg 1, 33615,
      Bielefeld, Germany. markus.rothhaar@ethik.med.uni-erlangen.de
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Med Health Care Philos
JT  - Medicine, health care, and philosophy
JID - 9815900
SB  - IM
MH  - *Bioethical Issues
MH  - Embryo Research/ethics
MH  - Ethical Theory
MH  - *Human Rights
MH  - Humans
MH  - *Personhood
MH  - Value of Life
EDAT- 2010/04/23 06:00
MHDA- 2010/12/21 06:00
CRDT- 2010/04/23 06:00
PHST- 2010/04/23 06:00 [entrez]
PHST- 2010/04/23 06:00 [pubmed]
PHST- 2010/12/21 06:00 [medline]
AID - 10.1007/s11019-010-9249-0 [doi]
PST - ppublish
SO  - Med Health Care Philos. 2010 Aug;13(3):251-7. doi: 10.1007/s11019-010-9249-0.


PMID- 20410892
OWN - NLM
STAT- MEDLINE
DCOM- 20100615
LR  - 20151119
IS  - 0093-7355 (Print)
IS  - 0093-7355 (Linking)
VI  - 39
IP  - 5
DP  - 2010 May
TI  - Cost: benefit evaluations for research protocols. Response: Pure ethical review.
PG  - 133-4
LID - 10.1038/laban0510-133b [doi]
FAU - Quinn, Robert
AU  - Quinn R
AD  - Dept. of Lab. Animal Resources, SUNY Upstate Medical University, Syracuse, NY,
      USA.
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Lab Anim (NY)
JT  - Lab animal
JID - 0417737
RN  - 0 (Biomarkers)
RN  - 0 (Tobacco Smoke Pollution)
SB  - IM
CON - Lab Anim (NY). 2010 May;39(5):133. PMID: 20410891
MH  - Animal Welfare/*ethics
MH  - Animals
MH  - Biomarkers
MH  - Biomedical Research/*economics
MH  - Cost-Benefit Analysis
MH  - Organizational Policy
MH  - Research Design
MH  - Risk Assessment
MH  - *Tobacco Smoke Pollution/adverse effects/ethics
EDAT- 2010/04/23 06:00
MHDA- 2010/06/16 06:00
CRDT- 2010/04/23 06:00
PHST- 2010/04/23 06:00 [entrez]
PHST- 2010/04/23 06:00 [pubmed]
PHST- 2010/06/16 06:00 [medline]
AID - laban0510-133b [pii]
AID - 10.1038/laban0510-133b [doi]
PST - ppublish
SO  - Lab Anim (NY). 2010 May;39(5):133-4. doi: 10.1038/laban0510-133b.


PMID- 20410288
OWN - NLM
STAT- MEDLINE
DCOM- 20101122
LR  - 20100728
IS  - 1546-8364 (Electronic)
IS  - 1059-8405 (Linking)
VI  - 26
IP  - 4 Suppl
DP  - 2010 Aug
TI  - Now more than ever: building and sustaining capacity for school-located
      vaccination initiatives.
PG  - 27S-29S
LID - 10.1177/1059840510368525 [doi]
AB  - The fall 2009 campaign to vaccinate high-risk U.S. residents against the 2009
      H1N1 influenza virus presented three key challenges that had significant impact
      on the effectiveness of campaigns conducted by local health departments (LHDs),
      schools, and other community partners. These issues included those of
      communication and trust, both between partners and with the public; the ethics
      and practicalities of getting vaccine to those at highest risk; and the planning 
      and execution of large-scale, school-located vaccination (SLV) clinics.
      Approaches to address these challenges and build sustainable local partnerships
      between schools and LHDs are explored.
FAU - Kuehnert, Paul
AU  - Kuehnert P
AD  - Health and Emergency Management, Kane County, Illinois, USA.
LA  - eng
PT  - Journal Article
DEP - 20100421
PL  - United States
TA  - J Sch Nurs
JT  - The Journal of school nursing : the official publication of the National
      Association of School Nurses
JID - 9206498
RN  - 0 (Influenza Vaccines)
MH  - Adolescent
MH  - Child
MH  - Humans
MH  - Influenza A Virus, H1N1 Subtype
MH  - *Influenza Vaccines
MH  - Influenza, Human/*prevention & control
MH  - Interinstitutional Relations
MH  - Mass Vaccination/*organization & administration
MH  - School Health Services/*organization & administration
MH  - School Nursing
MH  - United States
EDAT- 2010/04/23 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/04/23 06:00
PHST- 2010/04/23 06:00 [entrez]
PHST- 2010/04/23 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 1059840510368525 [pii]
AID - 10.1177/1059840510368525 [doi]
PST - ppublish
SO  - J Sch Nurs. 2010 Aug;26(4 Suppl):27S-29S. doi: 10.1177/1059840510368525. Epub
      2010 Apr 21.


PMID- 20409750
OWN - NLM
STAT- MEDLINE
DCOM- 20100628
LR  - 20100524
IS  - 1872-8952 (Electronic)
IS  - 1388-2457 (Linking)
VI  - 121
IP  - 6
DP  - 2010 Jun
TI  - Comment on: Safety, ethical considerations, and application guidelines for the
      use of transcranial magnetic stimulation in clinical practice and research, by
      Rossi et al. (2009).
PG  - 980
LID - 10.1016/j.clinph.2010.04.001 [doi]
FAU - Nyffeler, Thomas
AU  - Nyffeler T
FAU - Muri, Rene
AU  - Muri R
LA  - eng
PT  - Comment
PT  - Letter
DEP - 20100420
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of
      Clinical Neurophysiology
JID - 100883319
SB  - IM
CON - Clin Neurophysiol. 2009 Dec;120(12):2008-39. PMID: 19833552
MH  - Humans
MH  - Safety
MH  - Transcranial Magnetic Stimulation/*methods
EDAT- 2010/04/23 06:00
MHDA- 2010/06/29 06:00
CRDT- 2010/04/23 06:00
PHST- 2010/03/30 00:00 [received]
PHST- 2010/04/02 00:00 [accepted]
PHST- 2010/04/23 06:00 [entrez]
PHST- 2010/04/23 06:00 [pubmed]
PHST- 2010/06/29 06:00 [medline]
AID - S1388-2457(10)00342-1 [pii]
AID - 10.1016/j.clinph.2010.04.001 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 2010 Jun;121(6):980. doi: 10.1016/j.clinph.2010.04.001. Epub
      2010 Apr 20.


PMID- 20409516
OWN - NLM
STAT- MEDLINE
DCOM- 20100819
LR  - 20100803
IS  - 1879-1883 (Electronic)
IS  - 0002-9610 (Linking)
VI  - 200
IP  - 2
DP  - 2010 Aug
TI  - Control of presacral venous bleeding during rectal surgery.
PG  - e33-5
LID - 10.1016/j.amjsurg.2009.11.011 [doi]
AB  - BACKGROUND: Presacral venous hemorrhage is an uncommon but potentially
      life-threatening complication of rectal surgery. It is difficult to control
      presacral venous hemorrhage with conventional hemostatic measures and several
      alternative methods for hemostasis have been proposed. We described our
      experience of using the combination of a hemostatic matrix and an absorbable
      hemostat as an alternative method of hemostasis. METHODS: From September 2007 to 
      March 2009, 83 patients underwent rectal surgery for cancer, ulcerative colitis, 
      or familial adenomatous polyposis. Three patients (3.6%) had severe presacral
      hemorrhage, which was controlled by the combined use of a hemostatic matrix
      (FloSeal; Baxter, USA) and an absorbable hemostat (Surgicel Fibrillar; Ethicon,
      USA). RESULTS: Intraoperative blood transfusion was required in 1 patient.
      Postoperative blood loss was minimal and drain was removed on day 4 in all 3
      patients. CONCLUSIONS: The use of synthetic hemostatic agents is an effective and
      simple way to arrest presacral bleeding where conventional methods fail.
CI  - 2010. Published by Elsevier Inc.
FAU - Germanos, Stylianos
AU  - Germanos S
AD  - Patision General Hospital, Athens, Greece. Stylianos.germanos@yahoo.co.uk
FAU - Bolanis, Ioannis
AU  - Bolanis I
FAU - Saedon, Mahmud
AU  - Saedon M
FAU - Baratsis, Sotirios
AU  - Baratsis S
LA  - eng
PT  - Journal Article
DEP - 20100421
PL  - United States
TA  - Am J Surg
JT  - American journal of surgery
JID - 0370473
RN  - 0 (FloSeal Matrix)
RN  - 0 (Hemostatics)
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Colectomy/*adverse effects
MH  - Collagen/administration & dosage
MH  - Female
MH  - Gelatin Sponge, Absorbable/administration & dosage
MH  - Hemorrhage/etiology/*therapy
MH  - Hemostasis, Surgical/*methods
MH  - Hemostatics/*administration & dosage
MH  - Humans
MH  - Intraoperative Complications
MH  - Male
MH  - Middle Aged
MH  - Rectal Diseases/surgery
MH  - Rectum/*surgery
MH  - Retrospective Studies
MH  - Sacrococcygeal Region
MH  - Veins/*injuries
EDAT- 2010/04/23 06:00
MHDA- 2010/08/20 06:00
CRDT- 2010/04/23 06:00
PHST- 2009/07/05 00:00 [received]
PHST- 2009/11/04 00:00 [revised]
PHST- 2009/11/06 00:00 [accepted]
PHST- 2010/04/23 06:00 [entrez]
PHST- 2010/04/23 06:00 [pubmed]
PHST- 2010/08/20 06:00 [medline]
AID - S0002-9610(10)00088-7 [pii]
AID - 10.1016/j.amjsurg.2009.11.011 [doi]
PST - ppublish
SO  - Am J Surg. 2010 Aug;200(2):e33-5. doi: 10.1016/j.amjsurg.2009.11.011. Epub 2010
      Apr 21.


PMID- 20409343
OWN - NLM
STAT- MEDLINE
DCOM- 20110914
LR  - 20211020
IS  - 1471-2458 (Electronic)
IS  - 1471-2458 (Linking)
VI  - 10
DP  - 2010 Apr 21
TI  - Repeal of the Pennsylvania motorcycle helmet law: reflections on the ethical and 
      political dynamics of public health reform.
PG  - 202
LID - 10.1186/1471-2458-10-202 [doi]
AB  - BACKGROUND: In June of 2003 the Commonwealth of Pennsylvania passed S. 259 which 
      repealed the state's 35-year old motorcycle helmet safety law. Motorcycle helmets
      are now only required for riders who are under the age of 21 and for those who
      are 21 years or older who have had a motorcycle operator's license for less than 
      two years, or who have not completed an approved motorcycle safety course.
      DISCUSSION: Prior to the repeal, and in the years that have followed, there has
      been intense debate and controversy regarding Pennsylvania's decision to repeal
      the law that required universal and mandatory use of motorcycle helmets for all
      riders. Proponents of the helmet repeal have argued in favor of individual rights
      and freedom, whereas advocates for mandatory helmet laws have voiced concerns
      over public health and safety based on available data. SUMMARY: This commentary
      will discuss the policy-making process that led to Pennsylvania's repeal of the
      motorcycle helmet safety law from an ethical, political, and economic
      perspective.
FAU - Cherry, Robert A
AU  - Cherry RA
AD  - Surgery and Public Health Sciences, Penn State Shock Trauma Center, MC H075, Penn
      State Milton S Hershey Medical Center, 500 University Drive, Hershey,
      Pennsylvania 17033, USA. rcherry@psu.edu
LA  - eng
PT  - Journal Article
DEP - 20100421
PL  - England
TA  - BMC Public Health
JT  - BMC public health
JID - 100968562
SB  - IM
MH  - Adult
MH  - Head Protective Devices/*statistics & numerical data
MH  - *Health Care Reform/legislation & jurisprudence
MH  - Humans
MH  - Licensure
MH  - *Motorcycles/legislation & jurisprudence
MH  - Pennsylvania
MH  - *Public Health
MH  - Young Adult
PMC - PMC2864213
EDAT- 2010/04/23 06:00
MHDA- 2011/09/15 06:00
CRDT- 2010/04/23 06:00
PHST- 2009/11/10 00:00 [received]
PHST- 2010/04/21 00:00 [accepted]
PHST- 2010/04/23 06:00 [entrez]
PHST- 2010/04/23 06:00 [pubmed]
PHST- 2011/09/15 06:00 [medline]
AID - 1471-2458-10-202 [pii]
AID - 10.1186/1471-2458-10-202 [doi]
PST - epublish
SO  - BMC Public Health. 2010 Apr 21;10:202. doi: 10.1186/1471-2458-10-202.


PMID- 20408357
OWN - NLM
STAT- MEDLINE
DCOM- 20100525
LR  - 20211020
IS  - 0037-8046 (Print)
IS  - 0037-8046 (Linking)
VI  - 55
IP  - 2
DP  - 2010 Apr
TI  - Psychiatric advance directives and social workers: an integrative review.
PG  - 157-67
AB  - Psychiatric advance directives (PADs) are legal documents that allow individuals 
      to express their wishes for future psychiatric care and to authorize a legally
      appointed proxy to make decisions on their behalf during incapacitating crises.
      PADs are viewed as an alternative to the coercive interventions that sometimes
      accompany mental health crises for people with mental illness. Insofar as
      coercive interventions can abridge clients' autonomy and
      self-determination--values supported by the NASW Code of Ethics--social workers
      have a vested interest in finding ways to reduce coercion and increase autonomy
      and self-determination in their practice. However, PADs are also viewed as having
      the potential to positively affect a variety of other clinical outcomes,
      including, but not limited to, treatment engagement, treatment satisfaction, and 
      working alliance. This article reviews the clinical and legal history of PADs and
      empirical evidence for their implementation and effectiveness. Despite what
      should be an inherent interest in PADs and the fact that laws authorizing PADs
      have proliferated in the past decade, there is little theoretical or empirical
      research on PADS in the social work literature.
FAU - Van Dorn, Richard A
AU  - Van Dorn RA
AD  - Department of Mental Health Law and Policy, Florida Mental Health Institute,
      University of South Florida, Tampa, FL 33612, USA. rvandorn@fmhi.usf.edu
FAU - Scheyett, Anna
AU  - Scheyett A
FAU - Swanson, Jeffrey W
AU  - Swanson JW
FAU - Swartz, Marvin S
AU  - Swartz MS
LA  - eng
GR  - R01 MH063949/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Soc Work
JT  - Social work
JID - 2984852R
SB  - IM
MH  - *Advance Directives/legislation & jurisprudence
MH  - Coercion
MH  - Decision Making
MH  - Humans
MH  - Informed Consent
MH  - Mental Competency
MH  - Mental Disorders
MH  - *Mental Health Services
MH  - Patient Rights
MH  - *Psychiatry
MH  - *Social Work/education/methods
MH  - United States
RF  - 67
PMC - PMC3642872
MID - NIHMS465312
EDAT- 2010/04/23 06:00
MHDA- 2010/05/26 06:00
CRDT- 2010/04/23 06:00
PHST- 2010/04/23 06:00 [entrez]
PHST- 2010/04/23 06:00 [pubmed]
PHST- 2010/05/26 06:00 [medline]
AID - 10.1093/sw/55.2.157 [doi]
PST - ppublish
SO  - Soc Work. 2010 Apr;55(2):157-67. doi: 10.1093/sw/55.2.157.


PMID- 20408322
OWN - NLM
STAT- MEDLINE
DCOM- 20100610
LR  - 20211020
IS  - 1470-2118 (Print)
IS  - 1470-2118 (Linking)
VI  - 10
IP  - 1
DP  - 2010 Feb
TI  - Using umbilical cord blood stem cells for myocardial infarction and stroke is
      ethically challenging.
PG  - 97; author reply 97-8
FAU - Bewley, Susan
AU  - Bewley S
FAU - Mercer, Judith
AU  - Mercer J
LA  - eng
PT  - Comment
PT  - Letter
PL  - England
TA  - Clin Med (Lond)
JT  - Clinical medicine (London, England)
JID - 101092853
SB  - IM
CON - Clin Med (Lond). 2009 Aug;9(4):342-5. PMID: 19728507
MH  - Cord Blood Stem Cell Transplantation/*ethics
MH  - Humans
MH  - Myocardial Infarction/*therapy
MH  - Stroke/*therapy
PMC - PMC4954500
EDAT- 2010/04/23 06:00
MHDA- 2010/06/11 06:00
CRDT- 2010/04/23 06:00
PHST- 2010/04/23 06:00 [entrez]
PHST- 2010/04/23 06:00 [pubmed]
PHST- 2010/06/11 06:00 [medline]
AID - 10.7861/clinmedicine.10-1-97 [doi]
PST - ppublish
SO  - Clin Med (Lond). 2010 Feb;10(1):97; author reply 97-8. doi:
      10.7861/clinmedicine.10-1-97.


PMID- 20408302
OWN - NLM
STAT- MEDLINE
DCOM- 20100610
LR  - 20211020
IS  - 1470-2118 (Print)
IS  - 1470-2118 (Linking)
VI  - 10
IP  - 1
DP  - 2010 Feb
TI  - Core competencies for clinical ethics committees.
PG  - 30-3
AB  - Clinical ethics committees (CECs) are increasing in number in the UK and have
      mostly developed in response to local interest, as opposed to being mandated as
      in the USA. However, there is no regulatory framework for UK CECs with no defined
      educational requirements or specification of core competencies for their members.
      The UK Clinical Ethics Network has consulted extensively with its members to set 
      out, for the first time in the UK, the core competencies necessary for the
      provision of clinical ethics support. Recommendations for educational and
      membership requirements for CECs have also been made. Given the appropriate
      resources the standards proposed can be appropriately evaluated and are
      consistent with principles of ethical governance.
FAU - Larcher, Victor
AU  - Larcher V
AD  - Great Ormond Street Hospital, London.
FAU - Slowther, Anne-Marie
AU  - Slowther AM
FAU - Watson, Alan R
AU  - Watson AR
CN  - UK Clinical Ethics Network
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Clin Med (Lond)
JT  - Clinical medicine (London, England)
JID - 101092853
SB  - IM
MH  - *Clinical Competence
MH  - *Ethics Committees, Clinical
MH  - Ethics, Medical/*education
MH  - Humans
MH  - United Kingdom
MH  - United States
RF  - 19
PMC - PMC4954474
EDAT- 2010/04/23 06:00
MHDA- 2010/06/11 06:00
CRDT- 2010/04/23 06:00
PHST- 2010/04/23 06:00 [entrez]
PHST- 2010/04/23 06:00 [pubmed]
PHST- 2010/06/11 06:00 [medline]
AID - 10.7861/clinmedicine.10-1-30 [doi]
PST - ppublish
SO  - Clin Med (Lond). 2010 Feb;10(1):30-3. doi: 10.7861/clinmedicine.10-1-30.


PMID- 20408121
OWN - NLM
STAT- MEDLINE
DCOM- 20101228
LR  - 20151119
IS  - 1438-8782 (Electronic)
IS  - 0172-4614 (Linking)
VI  - 31
IP  - 4
DP  - 2010 Aug
TI  - Renal blood flow quantification in pigs using contrast-enhanced ultrasound: an ex
      vivo study.
PG  - 363-9
LID - 10.1055/s-0029-1245238 [doi]
AB  - PURPOSE: The aim of the study was to evaluate a new method for the quantification
      of renal blood flow using contrast-enhanced ultrasound (CEUS) in an ex vivo pig
      kidney model. MATERIAL AND METHODS: After approval by the animal ethics
      committee, 4 pig kidneys were explanted and perfused with Celsior liquid (Imtix
      Sangstat, Lyon, France) at different flow rates (30, 50, 70 and 90 ml/min) in an 
      ex vivo phantom. A 50 % diluted solution of SonoVue (Bracco, Milano, Italy) was
      infused in the artery at 0.5 ml/min. CEUS was performed with an Aplio system
      (Toshiba, Nasu, Japan) using a broadband linear transducer and pulse subtraction 
      imaging. A total of 152 destruction-reperfusion sequences were acquired and cine 
      loops were digitally stored for further quantification. Three different ROIs were
      placed upon the anterior, posterior cortex and segmental artery. Signal intensity
      measurements were performed in linear units and perfusion parameters were
      automatically extracted using dedicated software. Curve fitting was performed
      using a monoexponential model in which a time delay parameter was introduced.
      This fit allowed the assessment of the local blood flow into the region of
      interest (called "contrast-enhanced blood flow" (CEBF)). The artery mean signal
      intensity was averaged from the ten frames prior to the destruction phase. The
      normalized CEBF (nCEBF) was calculated as the ratio between CEBF and the mean
      arterial signal intensity. The CEBF and nCEBF were compared to the true blood
      flow indicated by the pump flow rate. RESULTS: The CEBF was correlated to the
      true blood flow only for the posterior cortical ROI (R(2) = 0.45, p = 0.05). The 
      normalization using arterial signals improved CEBF correlation to true blood
      flow: nCEBF became correlated to the true blood flow when considering all ROIs
      (R(2)= 0.94, p < 0.0001) and correlation was improved for both anterior and
      posterior cortical ROIs (R(2)= 0, 93, p = 0.0004; R(2)= 0, 90, p = 0.0005,
      respectively). However, a significant kidney-dependent effect was observed for
      the anterior cortical ROI (p = 0.017) but not for the posterior cortical ROI (p =
      0.89). CONCLUSION: Normalization using arterial signals significantly improved
      the estimation of blood flow calculated with CEUS.
CI  - Georg Thieme Verlag KG Stuttgart New York.
FAU - Hoeffel, C
AU  - Hoeffel C
AD  - Radiologie, Hopital Robert Debre, Reims. paul.fornes@wanadoo.fr
FAU - Mule, S
AU  - Mule S
FAU - Huwart, L
AU  - Huwart L
FAU - Frouin, F
AU  - Frouin F
FAU - Jais, J-P
AU  - Jais JP
FAU - Helenon, O
AU  - Helenon O
FAU - Correas, J-M
AU  - Correas JM
LA  - eng
PT  - Journal Article
DEP - 20100420
PL  - Germany
TA  - Ultraschall Med
JT  - Ultraschall in der Medizin (Stuttgart, Germany : 1980)
JID - 8303585
RN  - 0 (Contrast Media)
RN  - 0 (Phospholipids)
RN  - 0 (contrast agent BR1)
RN  - WS7LR3I1D6 (Sulfur Hexafluoride)
SB  - IM
CIN - Ultraschall Med. 2010 Aug;31(4):339-43. PMID: 20703970
MH  - Animals
MH  - Blood Flow Velocity/physiology
MH  - Contrast Media/*administration & dosage
MH  - Humans
MH  - *Image Enhancement
MH  - *Image Processing, Computer-Assisted
MH  - Kidney/*blood supply
MH  - *Phantoms, Imaging
MH  - *Phospholipids
MH  - Reference Values
MH  - Regional Blood Flow/physiology
MH  - Sensitivity and Specificity
MH  - Software
MH  - *Sulfur Hexafluoride
MH  - Swine
MH  - *Ultrasonography, Doppler, Color
EDAT- 2010/04/22 06:00
MHDA- 2010/12/29 06:00
CRDT- 2010/04/22 06:00
PHST- 2010/04/22 06:00 [entrez]
PHST- 2010/04/22 06:00 [pubmed]
PHST- 2010/12/29 06:00 [medline]
AID - 10.1055/s-0029-1245238 [doi]
PST - ppublish
SO  - Ultraschall Med. 2010 Aug;31(4):363-9. doi: 10.1055/s-0029-1245238. Epub 2010 Apr
      20.


PMID- 20407974
OWN - NLM
STAT- MEDLINE
DCOM- 20100709
LR  - 20100421
IS  - 1545-0848 (Electronic)
IS  - 1055-0887 (Linking)
VI  - 29
IP  - 2
DP  - 2010 Apr
TI  - Ethical issues and addiction.
PG  - 164-74
LID - 10.1080/10550881003684673 [doi]
AB  - The epidemic of substance abuse continues to pose a significant challenge to
      clinicians nationwide. Although there is a tendency to simply associate drug
      abuse with poverty, the problem affects every social stratum gender and race; and
      pregnant women are no exception. Caring for pregnant, substance-using women and
      their infants presents complex legal and ethical issues. Debate is ongoing about 
      whether criminal penalties should be imposed on women based solely on their use
      of alcohol and other drugs during pregnancy. Furthermore, controversies persist
      about the rights and wishes of pregnant women versus the interests of their
      fetuses. For health professionals, conflict arises when the pregnant woman
      chooses behaviors that have the potential to harm the developing fetus. The
      ethical dilemma arises from competing autonomy-based and beneficence-based
      obligations to the maternal-fetal dyad. This chapter explores the ethics-based
      conflicts in the delivery of health care to drug abusing pregnant women.
FAU - Lambert, Binta
AU  - Lambert B
AD  - Albert Einstein College of Medicine, Bronx, NY, USA.
FAU - Scheiner, Melissa
AU  - Scheiner M
FAU - Campbell, Deborah
AU  - Campbell D
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Addict Dis
JT  - Journal of addictive diseases
JID - 9107051
SB  - IM
MH  - Behavior, Addictive/psychology
MH  - *Beneficence
MH  - *Ethics, Medical
MH  - Female
MH  - Fetus/drug effects
MH  - Humans
MH  - Maternal-Fetal Relations
MH  - Moral Obligations
MH  - *Morals
MH  - Pregnancy
MH  - *Pregnant Women
MH  - *Public Policy
MH  - Substance-Related Disorders/prevention & control
MH  - United States
MH  - Women's Rights
EDAT- 2010/04/22 06:00
MHDA- 2010/07/10 06:00
CRDT- 2010/04/22 06:00
PHST- 2010/04/22 06:00 [entrez]
PHST- 2010/04/22 06:00 [pubmed]
PHST- 2010/07/10 06:00 [medline]
AID - 921457251 [pii]
AID - 10.1080/10550881003684673 [doi]
PST - ppublish
SO  - J Addict Dis. 2010 Apr;29(2):164-74. doi: 10.1080/10550881003684673.


PMID- 20407821
OWN - NLM
STAT- MEDLINE
DCOM- 20120524
LR  - 20211020
IS  - 1573-5168 (Electronic)
IS  - 0920-1742 (Linking)
VI  - 38
IP  - 1
DP  - 2012 Feb
TI  - Achieving consensus on current and future priorities for farmed fish welfare: a
      case study from the UK.
PG  - 219-29
LID - 10.1007/s10695-010-9399-2 [doi]
AB  - The welfare of farmed fish has attracted attention in recent years, which has
      resulted in notable changes within the aquaculture industry. However, a lack of
      communication between stakeholders and opposing ethical views are perceived as
      barriers to achieving consensus on how to improve farmed fish welfare. To address
      these issues, we developed an interactive approach that could be used during
      stakeholder meetings to (1) improve communication between different stakeholder
      groups, (2) build consensus on priorities for farmed fish welfare and (3)
      establish mechanisms to address welfare priorities. We then applied this approach
      during a meeting of stakeholders to identify current and future priorities for
      farmed fish welfare in the UK. During the meeting in the UK, stakeholders
      initially identified 32 areas that they felt were in need of development for
      future improvements in farmed fish welfare. These were further refined via peer
      review and discussion to the seven most important "priority" areas. Establishing 
      a "better understanding of what good fish welfare is" emerged as the highest
      priority area for farmed fish welfare. The second highest priority area was "the 
      need for welfare monitoring and documentation systems", with mortality recording 
      proposed as an example. The other five priority areas were "[improved
      understanding of] the role of genetic selection in producing fish suited to the
      farming environment", "a need for integration and application of behavioural and 
      physiological measures", "the need for a more liberal regime in Europe for
      introducing new medicines", "a need to address the issues of training existing
      and new workers within the industry", and "ensuring best practise in aquaculture 
      is followed by individual businesses". Feedback from attendees, and the meeting
      outputs, indicated that the approach had been successful in improving
      communication between stakeholders and in achieving consensus on the priorities
      for farmed fish welfare. The approach therefore proved highly beneficial for
      future improvements in fish welfare in the UK.
FAU - Berrill, I K
AU  - Berrill IK
AD  - Institute of Aquaculture, University of Stirling, Stirling, UK.
      iain.berrill@googlemail.com
FAU - Cooper, T
AU  - Cooper T
FAU - MacIntyre, C M
AU  - MacIntyre CM
FAU - Ellis, T
AU  - Ellis T
FAU - Knowles, T G
AU  - Knowles TG
FAU - Jones, E K M
AU  - Jones EK
FAU - Turnbull, J F
AU  - Turnbull JF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100421
PL  - Netherlands
TA  - Fish Physiol Biochem
JT  - Fish physiology and biochemistry
JID - 100955049
SB  - IM
MH  - *Animal Welfare/standards/trends
MH  - Animals
MH  - *Consensus
MH  - *Fisheries
MH  - Fishes/*physiology
MH  - United Kingdom
EDAT- 2010/04/22 06:00
MHDA- 2012/05/25 06:00
CRDT- 2010/04/22 06:00
PHST- 2009/11/02 00:00 [received]
PHST- 2010/04/05 00:00 [accepted]
PHST- 2010/04/22 06:00 [entrez]
PHST- 2010/04/22 06:00 [pubmed]
PHST- 2012/05/25 06:00 [medline]
AID - 10.1007/s10695-010-9399-2 [doi]
PST - ppublish
SO  - Fish Physiol Biochem. 2012 Feb;38(1):219-29. doi: 10.1007/s10695-010-9399-2. Epub
      2010 Apr 21.


PMID- 20407803
OWN - NLM
STAT- MEDLINE
DCOM- 20110614
LR  - 20211020
IS  - 1572-8358 (Electronic)
IS  - 0001-5342 (Linking)
VI  - 59
IP  - 1
DP  - 2011 Mar
TI  - Normative ethics does not need a foundation: it needs more science.
PG  - 29-51
LID - 10.1007/s10441-010-9096-7 [doi]
AB  - The impact of science on ethics forms since long the subject of intense debate.
      Although there is a growing consensus that science can describe morality and
      explain its evolutionary origins, there is less consensus about the ability of
      science to provide input to the normative domain of ethics. Whereas defenders of 
      a scientific normative ethics appeal to naturalism, its critics either see the
      naturalistic fallacy committed or argue that the relevance of science to
      normative ethics remains undemonstrated. In this paper, we argue that current
      scientific normative ethicists commit no fallacy, that criticisms of scientific
      ethics contradict each other, and that scientific insights are relevant to
      normative inquiries by informing ethics about the options open to the ethical
      debate. Moreover, when conceiving normative ethics as being a nonfoundational
      ethics, science can be used to evaluate every possible norm. This stands in
      contrast to foundational ethics in which some norms remain beyond scientific
      inquiry. Finally, we state that a difference in conception of normative ethics
      underlies the disagreement between proponents and opponents of a scientific
      ethics. Our argument is based on and preceded by a reconsideration of the notions
      naturalistic fallacy and foundational ethics. This argument differs from previous
      work in scientific ethics: whereas before the philosophical project of
      naturalizing the normative has been stressed, here we focus on concrete
      consequences of biological findings for normative decisions or on the day-to-day 
      normative relevance of these scientific insights.
FAU - Quintelier, Katinka
AU  - Quintelier K
AD  - Department of Philosophy and Moral Sciences, Research Unit 'The Moral Brain',
      Ghent University, Blandijnberg 2, 9000 Ghent, Belgium.
      katinka.quintelier@UGent.be
FAU - Van Speybroeck, Linda
AU  - Van Speybroeck L
FAU - Braeckman, Johan
AU  - Braeckman J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100421
PL  - Netherlands
TA  - Acta Biotheor
JT  - Acta biotheoretica
JID - 0421520
SB  - IM
MH  - *Ethical Theory
MH  - Humans
MH  - Science/*ethics
PMC - PMC3068523
EDAT- 2010/04/22 06:00
MHDA- 2011/06/15 06:00
CRDT- 2010/04/22 06:00
PHST- 2009/06/15 00:00 [received]
PHST- 2010/04/08 00:00 [accepted]
PHST- 2010/04/22 06:00 [entrez]
PHST- 2010/04/22 06:00 [pubmed]
PHST- 2011/06/15 06:00 [medline]
AID - 10.1007/s10441-010-9096-7 [doi]
PST - ppublish
SO  - Acta Biotheor. 2011 Mar;59(1):29-51. doi: 10.1007/s10441-010-9096-7. Epub 2010
      Apr 21.


PMID- 20406927
OWN - NLM
STAT- MEDLINE
DCOM- 20100908
LR  - 20220318
IS  - 1527-7755 (Electronic)
IS  - 0732-183X (Linking)
VI  - 28
IP  - 15
DP  - 2010 May 20
TI  - Ethics of mandatory research biopsy for correlative end points within clinical
      trials in oncology.
PG  - 2635-40
LID - 10.1200/JCO.2009.27.2443 [doi]
AB  - Clinical investigators in oncology are increasingly interested in using molecular
      analysis of cancer tissue to understand the biologic bases of response or
      resistance to novel interventions and to develop prognostic and predictive
      biomarkers that will guide clinical decision making. Some scientific questions of
      this nature can only be addressed, or may best be addressed, through the conduct 
      of a clinical trial in which research biopsies are obtained from all
      participants. However, trial designs with mandatory research biopsies have raised
      ethical concerns related to the risk of harm to participants, the adequacy of
      voluntary informed consent, and the potential for misunderstanding among research
      participants when access to an experimental intervention is linked to the
      requirement to undergo a research biopsy. In consideration of the ethical and
      scientific issues at stake in this debate, the Cancer and Leukemia Group B Ethics
      Committee proposes guidelines for clinical trials involving mandatory research
      biopsies. Any cancer clinical trial that requires research biopsies of
      participants must be well designed to address the scientific question, obtain the
      biopsy in a way that minimizes risk, and ensure that research participants are
      fully informed of the risks, rationale, and requirements of the study, as well as
      of treatment alternatives. Further guidelines and discussions of this issue are
      specified in this position paper. We feel that if these principles are respected,
      an informed adult with cancer can both understand and voluntarily consent to
      participation in a clinical trial involving mandatory research biopsy for
      scientific end points.
FAU - Peppercorn, Jeffrey
AU  - Peppercorn J
AD  - Division of Medical Oncology, Duke University Medical Center, Durham, NC 27710,
      USA. jeffrey.peppercorn@duke.edu
FAU - Shapira, Iuliana
AU  - Shapira I
FAU - Collyar, Deborah
AU  - Collyar D
FAU - Deshields, Teresa
AU  - Deshields T
FAU - Lin, Nancy
AU  - Lin N
FAU - Krop, Ian
AU  - Krop I
FAU - Grunwald, Hans
AU  - Grunwald H
FAU - Friedman, Paula
AU  - Friedman P
FAU - Partridge, Ann H
AU  - Partridge AH
FAU - Schilsky, Richard L
AU  - Schilsky RL
FAU - Bertagnolli, Monica M
AU  - Bertagnolli MM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100420
PL  - United States
TA  - J Clin Oncol
JT  - Journal of clinical oncology : official journal of the American Society of
      Clinical Oncology
JID - 8309333
SB  - IM
MH  - Adult
MH  - Biopsy/*ethics/methods
MH  - Clinical Trials as Topic/*ethics/methods
MH  - Endpoint Determination/ethics/methods
MH  - Humans
MH  - Mandatory Testing/*ethics/methods
MH  - Medical Oncology/*ethics/methods
PMC - PMC5596502
EDAT- 2010/04/22 06:00
MHDA- 2010/09/09 06:00
CRDT- 2010/04/22 06:00
PHST- 2010/04/22 06:00 [entrez]
PHST- 2010/04/22 06:00 [pubmed]
PHST- 2010/09/09 06:00 [medline]
AID - JCO.2009.27.2443 [pii]
AID - 10.1200/JCO.2009.27.2443 [doi]
PST - ppublish
SO  - J Clin Oncol. 2010 May 20;28(15):2635-40. doi: 10.1200/JCO.2009.27.2443. Epub
      2010 Apr 20.


PMID- 20406924
OWN - NLM
STAT- MEDLINE
DCOM- 20100908
LR  - 20100610
IS  - 1527-7755 (Electronic)
IS  - 0732-183X (Linking)
VI  - 28
IP  - 17
DP  - 2010 Jun 10
TI  - Equipoise lost: ethics, costs, and the regulation of cancer clinical research.
PG  - 2925-35
LID - 10.1200/JCO.2009.27.5404 [doi]
AB  - Cancer is the leading cause of death in Americans younger than 85 years of age
      and kills one American every 56 seconds. Advances in understanding of cancer
      biology have given us the potential to develop new, effective targeted therapies.
      However, progress is slowed by suboptimal/outdated clinical trial design
      paradigms and by regulatory complexity and rigidity. For instance, simulations
      suggest that restricting randomized trials to patients expressing drug target,
      instead of using unselected patient populations, could substantially reduce
      patient numbers required to demonstrate efficacy. High response rates that are
      achievable when patients and drugs are matched on the basis of molecular profiles
      may also make some randomized trials unnecessary or unjustifiable. Moreover,
      increasing the regulatory rigidity of clinical trials (regulatory fundamentalism)
      augments trial complexity and costs while slowing progress without demonstrating 
      meaningful safety benefits. Time from drug discovery to marketing increased from 
      8 years in 1960 to 12 to 15 years currently. Toxic death rates on phase I trials 
      have decreased from 0.8% in 1979 to 0.5% by 2002, but the estimated cost per
      life-year gained by tighter regulations is $2,700,000 (far higher than costs of
      other health measures), and simulations suggest that regulatory delays in
      development of effective therapies result in tens to hundreds of thousands of
      life-years lost, whereas stringent regulations save extremely few. Dysregulation 
      is also a major disincentive to patient and clinician participation in clinical
      research. In summary, current approaches squander research resources and
      discourage research participation, and the marked imbalance between potential
      life-years lost versus saved renders the regulatory burden potentially unethical.
      We outline suggested solutions.
FAU - Stewart, David J
AU  - Stewart DJ
AD  - Department of Thoracic/Head and Neck Medical Oncology, M D Anderson Cancer
      Center, Houston, TX 77030, USA. dstewart@mdanderson.org
FAU - Whitney, Simon N
AU  - Whitney SN
FAU - Kurzrock, Razelle
AU  - Kurzrock R
LA  - eng
PT  - Journal Article
DEP - 20100420
PL  - United States
TA  - J Clin Oncol
JT  - Journal of clinical oncology : official journal of the American Society of
      Clinical Oncology
JID - 8309333
SB  - IM
MH  - Biomedical Research
MH  - Clinical Trials as Topic/economics/ethics/*legislation & jurisprudence/*standards
MH  - Ethics, Research
MH  - Female
MH  - Humans
MH  - Male
MH  - Neoplasms/*therapy
MH  - Treatment Outcome
MH  - United States
EDAT- 2010/04/22 06:00
MHDA- 2010/09/09 06:00
CRDT- 2010/04/22 06:00
PHST- 2010/04/22 06:00 [entrez]
PHST- 2010/04/22 06:00 [pubmed]
PHST- 2010/09/09 06:00 [medline]
AID - JCO.2009.27.5404 [pii]
AID - 10.1200/JCO.2009.27.5404 [doi]
PST - ppublish
SO  - J Clin Oncol. 2010 Jun 10;28(17):2925-35. doi: 10.1200/JCO.2009.27.5404. Epub
      2010 Apr 20.


PMID- 20406878
OWN - NLM
STAT- MEDLINE
DCOM- 20100511
LR  - 20181023
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 340
DP  - 2010 Apr 20
TI  - Public to be asked its views on ethics of incentives for organ donation.
PG  - c2182
LID - 10.1136/bmj.c2182 [doi]
LID - bmj.c2182 [pii]
FAU - Hayes, Josephine
AU  - Hayes J
LA  - eng
PT  - News
DEP - 20100420
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
SB  - IM
MH  - *Attitude to Health
MH  - Humans
MH  - Motivation/*ethics
MH  - *Public Opinion
MH  - Tissue and Organ Procurement/*ethics/legislation & jurisprudence
MH  - United Kingdom
EDAT- 2010/04/22 06:00
MHDA- 2010/05/12 06:00
CRDT- 2010/04/22 06:00
PHST- 2010/04/22 06:00 [entrez]
PHST- 2010/04/22 06:00 [pubmed]
PHST- 2010/05/12 06:00 [medline]
AID - 10.1136/bmj.c2182 [doi]
PST - epublish
SO  - BMJ. 2010 Apr 20;340:c2182. doi: 10.1136/bmj.c2182.


PMID- 20406474
OWN - NLM
STAT- MEDLINE
DCOM- 20101129
LR  - 20220331
IS  - 1758-3284 (Electronic)
IS  - 1758-3284 (Linking)
VI  - 2
DP  - 2010 Apr 20
TI  - Clinicopathological parameters, recurrence, locoregional and distant metastasis
      in 115 T1-T2 oral squamous cell carcinoma patients.
PG  - 9
LID - 10.1186/1758-3284-2-9 [doi]
AB  - The incidence of oral squamous cell carcinoma remains high. Oral and
      oro-pharyngeal carcinomas are the sixth most common cancer in the world. Several 
      clinicopathological parameters have been implicated in prognosis, recurrence and 
      survival, following oral squamous cell carcinoma. In this retrospective analysis,
      clinicopathological parameters of 115 T1/T2 OSCC were studied and compared to
      recurrence and death from tumour-related causes. The study protocol was approved 
      by the Joint UCL/UCLH committees of the ethics for human research. The patients' 
      data was entered onto proformas, which were validated and checked by interval
      sampling. The fields included a range of clinical, operative and
      histopathological variables related to the status of the surgical margins. Data
      collection also included recurrence, cause of death, date of death and last
      clinic review. Causes of death were collated in 4 categories (1) death from
      locoregional spread, (2) death from distant metastasis, (3) death from
      bronchopulmonary pneumonia, and (4) death from any non-tumour event that lead to 
      cardiorespiratory failure. The patients' population comprised 65 males and 50
      females. Their mean age at the 1st diagnosis of OSCC was 61.7 years. Two-thirds
      of the patients were Caucasians. Primary sites were mainly identified in the
      tongue, floor of mouth (FOM), buccal mucosa and alveolus. Most of the identified 
      OSCCs were low-risk (T1N0 and T2N0). All patients underwent primary resection +/-
      neck dissection and reconstruction when necessary. Twenty-two patients needed
      adjuvant radiotherapy. Pathological analysis revealed that half of the patients
      had moderately differentiated OSCC. pTNM slightly differed from the cTNM and
      showed that 70.4% of the patients had low-risk OSCC. Tumour clearance was
      ultimately achieved in 107 patients. Follow-up resulted in a 3-year survival of
      74.8% and a 5-year survival of 72.2%. Recurrence was identified in 23 males and
      20 females. The mean age of 1st diagnosis of the recurrence group was 59.53
      years. Most common oral sites included the lateral border of tongue and floor of 
      mouth. Recurrence was associated with clinical N-stage disease. The surgical
      margins in this group was evaluated and found that 17 had non-cohesive invasion, 
      30 had dysplasia at margin, 21 had vascular invasion, 9 had nerve invasion and 3 
      had bony invasion. Severe dysplasia was present in 37 patients. Tumour clearance 
      was achieved in only 8 patients. The mean depth of tumour invasion in the
      recurrence group was 7.6 mm.An interesting finding was that 5/11 patients who
      died of distant metastasis had their primary disease in the tongue. Nodal disease
      comparison showed that 8/10 patients who died of locoregional metastasis and 8/11
      patients who died from distant metastasis had clinical nodal involvement.
      Comparing this to pathological nodal disease (pTNM) showed that 10/10 patients
      and 10/11 patients who died from locoregional and distant metastasis,
      respectively, had nodal disease. All patients who died from locoregional and
      distant metastasis were shown to have recurrence after the primary tumour
      resection. Squamous cell carcinoma of the oral cavity has a poor overall
      prognosis with a high tendency to recur at the primary site and extend to involve
      the cervical lymph nodes. Several clinicopathological parameters can be employed 
      to assess outcome, recurrence and overall survival.
FAU - Jerjes, Waseem
AU  - Jerjes W
AD  - UCLH Head and Neck Centre, London, UK. waseem_wk1@yahoo.co.uk
FAU - Upile, Tahwinder
AU  - Upile T
FAU - Petrie, Aviva
AU  - Petrie A
FAU - Riskalla, Andrew
AU  - Riskalla A
FAU - Hamdoon, Zaid
AU  - Hamdoon Z
FAU - Vourvachis, Michael
AU  - Vourvachis M
FAU - Karavidas, Kostas
AU  - Karavidas K
FAU - Jay, Amrita
AU  - Jay A
FAU - Sandison, Ann
AU  - Sandison A
FAU - Thomas, Gareth J
AU  - Thomas GJ
FAU - Kalavrezos, Nicholas
AU  - Kalavrezos N
FAU - Hopper, Colin
AU  - Hopper C
LA  - eng
PT  - Journal Article
DEP - 20100420
PL  - England
TA  - Head Neck Oncol
JT  - Head & neck oncology
JID - 101479704
SB  - IM
MH  - Carcinoma, Squamous Cell/*pathology/radiotherapy/surgery
MH  - Female
MH  - Humans
MH  - Lymphatic Metastasis
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Middle Aged
MH  - Mouth Neoplasms/*pathology/radiotherapy/surgery
MH  - Neoplasm Metastasis
MH  - Neoplasm Recurrence, Local/pathology
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Retrospective Studies
MH  - Survival Analysis
MH  - Tomography, X-Ray Computed
MH  - Treatment Outcome
PMC - PMC2882907
EDAT- 2010/04/22 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/04/22 06:00
PHST- 2010/03/05 00:00 [received]
PHST- 2010/04/20 00:00 [accepted]
PHST- 2010/04/22 06:00 [entrez]
PHST- 2010/04/22 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 1758-3284-2-9 [pii]
AID - 10.1186/1758-3284-2-9 [doi]
PST - epublish
SO  - Head Neck Oncol. 2010 Apr 20;2:9. doi: 10.1186/1758-3284-2-9.


PMID- 20406128
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20161018
IS  - 1437-4331 (Electronic)
IS  - 1434-6621 (Linking)
VI  - 48
IP  - 7
DP  - 2010 Jul
TI  - Evaluating laboratory diagnostic tests and translational research.
PG  - 983-8
LID - 10.1515/CCLM.2010.188 [doi]
AB  - In laboratory medicine, the evaluation of an assay is reasonably straightforward 
      and allows broad applicable standards to be established. In contrast, the
      evaluation of a test is more complex and inherently less susceptible to
      standardization. The term "test" refers to the use of an assay in the context of 
      a particular disease, in a particular population, and for a particular purpose.
      Therefore, the true evaluation is to demonstrate its effectiveness in helping a
      clinician achieve a correct diagnosis or improve patient clinical outcomes. The
      debate on the current weak framework used for evaluating laboratory tests has
      been stimulated by recent technological developments, in particular "omics"
      tests. Currently, consensus has been achieved concerning the proposal to use a
      model based on at least four steps to be investigated. These are analytical and
      clinical validity, clinical usefulness and, finally, any ethical, social and
      legal implications, including economic implications. As the pace of technological
      advancements in laboratory medicine accelerates, it is time to discuss the role
      of laboratory testing, and the related role of clinical laboratories. In
      particular, we should consider whether they should evolve as focused factories of
      numbers and results, or as knowledge services with an emphasis on improving
      appropriateness in test requesting, and the interpretation and utilization of
      laboratory information.
FAU - Plebani, Mario
AU  - Plebani M
AD  - Department of Laboratory Medicine, University-Hospital of Padova, Padova, Italy. 
      mario.plebani@unipd.it
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Clin Chem Lab Med
JT  - Clinical chemistry and laboratory medicine
JID - 9806306
SB  - IM
MH  - *Clinical Laboratory Techniques/economics/standards
MH  - Diagnostic Tests, Routine
MH  - Humans
MH  - Laboratories/economics/standards
MH  - Research
RF  - 38
EDAT- 2010/04/22 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/04/22 06:00
PHST- 2010/04/22 06:00 [entrez]
PHST- 2010/04/22 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - 10.1515/CCLM.2010.188 [doi]
PST - ppublish
SO  - Clin Chem Lab Med. 2010 Jul;48(7):983-8. doi: 10.1515/CCLM.2010.188.


PMID- 20405976
OWN - NLM
STAT- MEDLINE
DCOM- 20101124
LR  - 20100421
IS  - 1132-1989 (Print)
IS  - 1132-1989 (Linking)
VI  - 21
IP  - 71
DP  - 2010 Jan-Apr
TI  - [Deficiencies in consent forms for genomic research].
PG  - 95-108
AB  - INTRODUCTION: whenever biological samples are requested for genomic research
      consent from donors is always needed. in this process, appropriate information
      offered to participants is essential. the aim of this study is to assess the
      information included in consent forms from genomic studies. MATERIAL AND METHODS:
      a 51-item checklist was used to perform a content analysis of consent forms
      offered to sample donors. We included all consent forms used in genomic research 
      projects approved by an Ethics Review Committee between 2004 and 2007. RESULTS:
      consent forms from 68 genomic studies were reviewed. 58 (85%) of those were
      international studies and promoted by the pharmaceutical industry. We found some 
      important deficiencies in the consent forms on the information related to the
      sample's use: less than 50% mentioned aspects related to the ownership of the
      sample, the free donation of the sample or the place of sample storage. There
      have also been frequent omissions related to the genetic data such as the right
      to know the results of the research, the disclosure of information to family
      members or the length of time during which these genetic data will be stored.
      CONCLUSIONS: important omissions have been found in the assessed consent forms on
      aspects related to the use of samples and genetic data. Therefore, a substantial 
      improvement should be undertaken in the consent forms in order to comply both
      with the requirements established in the Spanish biomedical law and the ethical
      demands.
FAU - Saenz de Tejada Lopez, M
AU  - Saenz de Tejada Lopez M
AD  - Hospital Clinico San Carlos, Madrid. martalst@yahoo.es <martalst@yahoo.es>
FAU - Valle Mansilla, J I
AU  - Valle Mansilla JI
FAU - Ruiz-Canela, M
AU  - Ruiz-Canela M
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Deficiencias en las Hojas de Informacion de Estudios Genomicos.
PL  - Spain
TA  - Cuad Bioet
JT  - Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y
      Etica Medica
JID - 101312976
SB  - IM
MH  - Consent Forms/*standards
MH  - Genetic Association Studies/*ethics
MH  - Humans
MH  - Pharmacogenetics/*ethics
EDAT- 2010/04/22 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/04/22 06:00
PHST- 2009/02/18 00:00 [received]
PHST- 2009/06/02 00:00 [accepted]
PHST- 2010/04/22 06:00 [entrez]
PHST- 2010/04/22 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - Cuad Bioet. 2010 Jan-Apr;21(71):95-108.


PMID- 20405975
OWN - NLM
STAT- MEDLINE
DCOM- 20101124
LR  - 20100421
IS  - 1132-1989 (Print)
IS  - 1132-1989 (Linking)
VI  - 21
IP  - 71
DP  - 2010 Jan-Apr
TI  - [The abortion from bioethics: autonomy of woman and physician?].
PG  - 79-93
AB  - In this reflection on abortion, we will analyze from the bioethics viewpoint the 
      concept of autonomy, in accordance with the liberal individual model and personal
      ambitions to be applied to the woman's and the doctor's decision making and the
      society in general. Now that the abortion liberalization is being proposed in
      Spain through a law that intends to substitute the decriminalization of certain
      assumptions that have been in effect since 1985, it is necessary to analyze in
      deep the ethical aspects beyond the legal and social approaches. Bioethics and
      Law must join together, since both have the same aim: the promotion of human life
      respect and its basic rights; safeguard -as long as possible-, the values within 
      an interpersonal relationship that lead to fulfill a woman's life having an
      unwanted pregnancy, as well as that of the fetus and the doctor; and always
      trying to protect the rights of those who are the weakest: the woman and the
      fetus, without disregarding everyone's duties with them.
FAU - Leon Correa, Francisco Javier
AU  - Leon Correa FJ
AD  - Centro de Bioetica Facultad de Medicina, Pontificia Universidad Catolica de
      Chile, Santiago de Chile. fleonc@uc.cl
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - El Aborto desde la Bioetica: inverted question markAutonomia de la Mujer y del
      Medico?
PL  - Spain
TA  - Cuad Bioet
JT  - Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y
      Etica Medica
JID - 101312976
SB  - IM
MH  - Abortion, Induced/*education
MH  - *Bioethical Issues
MH  - Female
MH  - Humans
MH  - *Personal Autonomy
MH  - *Physicians
MH  - Pregnancy
MH  - *Women
EDAT- 2010/04/22 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/04/22 06:00
PHST- 2009/02/28 00:00 [received]
PHST- 2009/06/08 00:00 [accepted]
PHST- 2010/04/22 06:00 [entrez]
PHST- 2010/04/22 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - Cuad Bioet. 2010 Jan-Apr;21(71):79-93.


PMID- 20405974
OWN - NLM
STAT- MEDLINE
DCOM- 20101124
LR  - 20140325
IS  - 1132-1989 (Print)
IS  - 1132-1989 (Linking)
VI  - 21
IP  - 71
DP  - 2010 Jan-Apr
TI  - [Freedom of conscience. Biojuridical conflicts at multicultural societies].
PG  - 61-77
AB  - The paper analyzes the right of healthcare professionals to conscientious
      objection at multicultural societies. the ethical relativism, characteristic of
      these societies, lives together with an apparently paradoxical reduction of the
      exercise of freedom of conscience. It is wrote "Apparently" because, at the end, 
      the ethical relativism tends to the adoption of dogmatic attitudes. Special
      attention is paid to the situation of Spanish healthcare in relation with
      euthanasia and abortion. With regard to euthanasia, the "dignified dead" draft
      bill of Andalucia is considered. With regard to abortion, we will pay attention
      to the reform of the Penal Code in the context of a new regulation about
      "reproductive health" of women, which means the adoption of a system of time
      limits, and the characterization of abortion as a women's right. It is concluded 
      that the freedom of conscience of healthcare professionals would be probably at
      risk if proposed legal policies doesn't change.
FAU - Albert Marquez, Marta
AU  - Albert Marquez M
AD  - Universidad Rey Juan Carlos, Vicalvaro, Madrid. marta.albert@urjc.es
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Libertad de Conciencia. Conflictos Biojuridicos en las Sociedades
      Multiculturales.
PL  - Spain
TA  - Cuad Bioet
JT  - Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y
      Etica Medica
JID - 101312976
SB  - IM
MH  - Bioethical Issues/*legislation & jurisprudence
MH  - *Conscience
MH  - *Cultural Diversity
MH  - *Freedom
MH  - Humans
EDAT- 2010/04/22 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/04/22 06:00
PHST- 2009/05/15 00:00 [received]
PHST- 2009/08/19 00:00 [accepted]
PHST- 2010/04/22 06:00 [entrez]
PHST- 2010/04/22 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - Cuad Bioet. 2010 Jan-Apr;21(71):61-77.


PMID- 20405973
OWN - NLM
STAT- MEDLINE
DCOM- 20101124
LR  - 20100421
IS  - 1132-1989 (Print)
IS  - 1132-1989 (Linking)
VI  - 21
IP  - 71
DP  - 2010 Jan-Apr
TI  - [Patients' autonomy and doctors' duties according to the Andalusian bill of
      "dignified dead"].
PG  - 51-60
AB  - The provisions of the andalusian Law on rights and guarantees of the dignity of
      persons in the process of death, also known as "act of dignified death", are
      based on two pillars: the right to the autonomy of the patient, supported, if it 
      be, in a will expressed in instructions given in advance and the duties of
      doctors and health centers to give satisfaction, to the extent of their potential
      and respecting the law, those demands. the core of the question is to find the
      point of necessary balance between the wishes of the patient and the freedom and 
      responsibility of the doctor. Together with positive aspects, such as the
      recognition of the right and the implementation of the palliative care, there are
      other questionable proposals, affecting the rights of doctors: a lack of
      understanding of freedom and professional responsibility, recognition of the
      objection of conscience and certain ethics duties, etc. As expressed by the law, 
      remain committed substantial rights of doctors and might favor, in the care
      activity, introducing practices of defensive medicine.
FAU - Diez Fernandez, Jose Antonio
AU  - Diez Fernandez JA
AD  - Asociacion para la Defensa del Derecho a la Objecion de conciencia, Jaen.
      jadiez@andoc.es
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Autonomia del Paciente y Deberes del Medico en el Proyecto de Ley Andaluza de
      "Muerte Digna"
PL  - Spain
TA  - Cuad Bioet
JT  - Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y
      Etica Medica
JID - 101312976
SB  - IM
MH  - *Ethics, Medical
MH  - Humans
MH  - Palliative Care/*legislation & jurisprudence
MH  - Patient Rights/*legislation & jurisprudence
MH  - *Personal Autonomy
MH  - Right to Die/*legislation & jurisprudence
MH  - Spain
EDAT- 2010/04/22 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/04/22 06:00
PHST- 2009/06/07 00:00 [received]
PHST- 2010/01/23 00:00 [accepted]
PHST- 2010/04/22 06:00 [entrez]
PHST- 2010/04/22 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - Cuad Bioet. 2010 Jan-Apr;21(71):51-60.


PMID- 20405972
OWN - NLM
STAT- MEDLINE
DCOM- 20101124
LR  - 20100421
IS  - 1132-1989 (Print)
IS  - 1132-1989 (Linking)
VI  - 21
IP  - 71
DP  - 2010 Jan-Apr
TI  - [The ambiguity of the bioethics' principles].
PG  - 39-48
AB  - The principles of the bioethics, coined in United States at the end of the
      seventies and diffused in our social environment one decade later, enclose inside
      a semantic ambiguity that here it is analyzed in their master lines; this
      ambiguity oscillates between a relativistic meaning and another agreed with the
      classic concept of Nature; this ambiguity has been transmitted to who, being part
      of the field of the Hippocratic medical ethics, have adopted its terminology, and
      these are the immense majority of the medical class. This phenomenon is easily
      leading towards the abandonment of the medical ethics based on the natural law
      (the Hippocratic-Christian tradition), to make it finish in a more or less clear 
      relativism. to avoid this problem, some solutions in the field of the medical
      ethical terminology are proposed.
FAU - Pardo Caballos, Antonio
AU  - Pardo Caballos A
AD  - Departamento de Humanidades Biomedicas, Universidad de Navarra, Irunlarrea,
      Pamplona. apardo@unav.es
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - La Ambiguedad de los Principios de la Bioetica.
PL  - Spain
TA  - Cuad Bioet
JT  - Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y
      Etica Medica
JID - 101312976
SB  - IM
MH  - *Bioethics
MH  - Ethical Relativism
MH  - *Principle-Based Ethics
EDAT- 2010/04/22 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/04/22 06:00
PHST- 2009/07/06 00:00 [received]
PHST- 2009/08/19 00:00 [accepted]
PHST- 2010/04/22 06:00 [entrez]
PHST- 2010/04/22 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - Cuad Bioet. 2010 Jan-Apr;21(71):39-48.


PMID- 20405971
OWN - NLM
STAT- MEDLINE
DCOM- 20101124
LR  - 20100421
IS  - 1132-1989 (Print)
IS  - 1132-1989 (Linking)
VI  - 21
IP  - 71
DP  - 2010 Jan-Apr
TI  - [The biologization of ethics].
PG  - 21-38
AB  - Three ethics exist as a condition of possibility of any possible ethics,
      following a material and biological foundation. This content argument (not
      logical-formal) supposes a refutation of the naturalistic fallacy that the
      analytical philosophy attributes to Hume, in three areas of the ethical human
      experience: body, society and nature. These are: the ethics of the species [J.
      Habermas], the ethics of liberation [E. Dussel] and the ethics of the
      responsibility [H. Jonas]. This material argument is a philosophical foundation
      to considering for three types of applied ethics: medical bioethics, development 
      ethics and environmental ethics.
FAU - Moreno Lax, Alejandro
AU  - Moreno Lax A
AD  - Universidad de Murcia, Spain. alezheia@yahoo.es
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Biologizacion de la Etica.
PL  - Spain
TA  - Cuad Bioet
JT  - Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y
      Etica Medica
JID - 101312976
SB  - IM
MH  - *Bioethics
MH  - Humans
EDAT- 2010/04/22 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/04/22 06:00
PHST- 2010/10/08 00:00 [received]
PHST- 2010/03/05 00:00 [accepted]
PHST- 2010/04/22 06:00 [entrez]
PHST- 2010/04/22 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - Cuad Bioet. 2010 Jan-Apr;21(71):21-38.


PMID- 20405970
OWN - NLM
STAT- MEDLINE
DCOM- 20101124
LR  - 20100421
IS  - 1132-1989 (Print)
IS  - 1132-1989 (Linking)
VI  - 21
IP  - 71
DP  - 2010 Jan-Apr
TI  - [Ethics as first philosophy: the ethics of responsibility as a rationale for
      health care].
PG  - 13-20
AB  - The origins of bioethics as a discipline arouse from the need to provide an
      answer to new ethical questions generated as a result of technological advances
      in the health field and the new arenas in which biomedical research began to
      develop. Discussions were first focused on the relevance of the applicability of 
      new technologies and the need to redefine a number of concepts related to the
      beginning and end of life. Then, over the years, this discipline was shaped and
      reconfigured incorporating issues related to the process of decision making in
      daily medical care, patient rights, protection of their freedoms and obligations 
      of medical professionals, among others. The purpose of this essay is to reflect
      upon the ethical foundations of health care, trying to provide an answer to the
      question "why movide care" in light of the thought of Emmanuel Levinas.
FAU - Belli, Laura Florencia
AU  - Belli LF
AD  - Universidad de Buenos Aires, Ciudad Autonoma de Buenos Aires. C.P., Buenos Aires.
      laurabelli@gmail.com
FAU - Quadrelli, Silvia
AU  - Quadrelli S
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - La Etica como Filosofia Primera: una Fundamentacion del Cuidado Medico desde la
      Etica de la Responsabilidad.
PL  - Spain
TA  - Cuad Bioet
JT  - Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y
      Etica Medica
JID - 101312976
SB  - IM
MH  - Bioethical Issues
MH  - Delivery of Health Care/*ethics
MH  - Philosophy
EDAT- 2010/04/22 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/04/22 06:00
PHST- 2009/02/28 00:00 [received]
PHST- 2009/08/27 00:00 [accepted]
PHST- 2010/04/22 06:00 [entrez]
PHST- 2010/04/22 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - Cuad Bioet. 2010 Jan-Apr;21(71):13-20.


PMID- 20405595
OWN - NLM
STAT- MEDLINE
DCOM- 20100511
LR  - 20191210
IS  - 0961-7671 (Print)
IS  - 0961-7671 (Linking)
VI  - 18
IP  - 1
DP  - 2010 Feb
TI  - Direct-to-consumer advertising: Australian pharmacists' experiences with
      non-prescription medicines.
PG  - 43-50
AB  - OBJECTIVE: Direct-to-consumer advertising (DTCA) of over-the-counter or
      prescribed medicines is a highly controversial issue relating to public health
      care. Advocates highlight the advantages of DTCA in terms of patient awareness
      and autonomy. Opponents voice concerns about safety and patients' best interests.
      The views of physicians and consumers about DTCA have been widely investigated.
      There has been little research, however, in relation to pharmacists' experiences 
      with DTCA and the impact of DTCA on pharmacy practice. The aim of this study was 
      therefore to explore pharmacists' perceptions of DTCA in Australia and its impact
      on pharmacy practice. METHODS: A semi-structured in-depth interview was conducted
      with a purposive convenience sample of retail pharmacists in Sydney, Australia.
      Interviews were recorded, transcribed ad verbatim and continued until data
      saturation. Emerging themes were extracted and analysed according to the grounded
      theory approach. KEY FINDINGS: Pharmacists participating in this study reported
      concern about potential harm to patient health and well-being as a result of the 
      influence of DTCA. DTCA was seen to impede pharmacists in the discharge of their 
      fundamental ethical responsibilities, leading to a strong sense of
      disempowerment. Pharmacists' gate-keeping role was challenged by DTCA encouraging
      consumers to self-medicate and inducing a range of drug-seeking behaviours.
      Although pharmacists acknowledged that DTCA may have a role in promoting patient 
      autonomy, in practice DTCA compromised their role in safeguarding consumers from 
      inappropriate use of medicines. CONCLUSIONS: This study highlighted that the
      impact of DTCA is not restricted to prescription medicines, but extended also to 
      over-the-counter, pharmacist-only and other pharmacy-related products.
      Pharmacists perceived that DTCA disempowered them, compromising their role in
      safeguarding the community from inappropriate medicine use.
FAU - Chaar, Betty
AU  - Chaar B
AD  - Faculty of Pharmacy, University of Sydney, New South Wales, Australia.
      b.chaar@pharm.usyd.edu.au
FAU - Kwong, Kenelm
AU  - Kwong K
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Pharm Pract
JT  - The International journal of pharmacy practice
JID - 9204243
RN  - 0 (Nonprescription Drugs)
SB  - IM
MH  - Advertising/*methods
MH  - Attitude of Health Personnel
MH  - Australia
MH  - Community Pharmacy Services/economics
MH  - Consumer Health Information/economics
MH  - Female
MH  - Humans
MH  - Information Dissemination/*methods
MH  - Male
MH  - Nonprescription Drugs
MH  - Professional Role/psychology
EDAT- 2010/04/22 06:00
MHDA- 2010/05/12 06:00
CRDT- 2010/04/22 06:00
PHST- 2010/04/22 06:00 [entrez]
PHST- 2010/04/22 06:00 [pubmed]
PHST- 2010/05/12 06:00 [medline]
AID - 10.1211/ijpp.18.01.0008 [doi]
PST - ppublish
SO  - Int J Pharm Pract. 2010 Feb;18(1):43-50. doi: 10.1211/ijpp.18.01.0008.


PMID- 20405571
OWN - NLM
STAT- MEDLINE
DCOM- 20100423
LR  - 20100420
IS  - 0023-7205 (Print)
IS  - 0023-7205 (Linking)
VI  - 107
IP  - 10
DP  - 2010 Mar 10-16
TI  - [Important to ethically scrutinize health care reforms].
PG  - 698
FAU - Halldin, Jan
AU  - Halldin J
LA  - swe
PT  - Comment
PT  - Letter
TT  - Angelaget att etiskt granska vardreformer.
PL  - Sweden
TA  - Lakartidningen
JT  - Lakartidningen
JID - 0027707
SB  - IM
CON - Lakartidningen. 2010 Feb 17-23;107(7):412-3. PMID: 20384072
MH  - *Ethics, Medical
MH  - Health Care Reform/*ethics
MH  - Health Policy
MH  - Humans
EDAT- 2010/04/21 06:00
MHDA- 2010/04/24 06:00
CRDT- 2010/04/21 06:00
PHST- 2010/04/21 06:00 [entrez]
PHST- 2010/04/21 06:00 [pubmed]
PHST- 2010/04/24 06:00 [medline]
PST - ppublish
SO  - Lakartidningen. 2010 Mar 10-16;107(10):698.


PMID- 20405537
OWN - NLM
STAT- MEDLINE
DCOM- 20100503
LR  - 20190612
IS  - 1474-547X (Electronic)
IS  - 0140-6736 (Linking)
VI  - 375
IP  - 9723
DP  - 2010 Apr 17
TI  - Is there an ethical obligation to complete polio eradication?
PG  - 1340-1
FAU - Emerson, Claudia I
AU  - Emerson CI
FAU - Singer, Peter A
AU  - Singer PA
LA  - eng
PT  - News
PL  - England
TA  - Lancet
JT  - Lancet (London, England)
JID - 2985213R
RN  - 0 (Poliovirus Vaccines)
SB  - IM
MH  - *Ethics
MH  - *Global Health
MH  - Humans
MH  - Poliomyelitis/*prevention & control
MH  - Poliovirus Vaccines/administration & dosage/economics
EDAT- 2010/04/21 06:00
MHDA- 2010/05/04 06:00
CRDT- 2010/04/21 06:00
PHST- 2010/04/21 06:00 [entrez]
PHST- 2010/04/21 06:00 [pubmed]
PHST- 2010/05/04 06:00 [medline]
AID - S0140-6736(10)60565-X [pii]
AID - 10.1016/s0140-6736(10)60565-x [doi]
PST - ppublish
SO  - Lancet. 2010 Apr 17;375(9723):1340-1. doi: 10.1016/s0140-6736(10)60565-x.


PMID- 20405244
OWN - NLM
STAT- MEDLINE
DCOM- 20101220
LR  - 20211020
IS  - 1572-8633 (Electronic)
IS  - 1386-7423 (Linking)
VI  - 13
IP  - 3
DP  - 2010 Aug
TI  - Human rights for women: the ethical and legal discussion about Female Genital
      Mutilation in Germany in comparison with other Western European countries.
PG  - 269-78
LID - 10.1007/s11019-010-9245-4 [doi]
AB  - Within Western European countries the number of women and girls already genitally
      mutilated or at risk, is rising due to increasing rates of migration of Africans.
      The article compares legislative and ethical practices within the medical
      profession concerning female genital mutilation (FGM) in these countries. There
      are considerable differences in the number of affected women and in legislation
      and guidelines. For example, in France, Great Britain and Austria FGM is included
      in the criminal code as elements of crime, whereas in Germany and Switzerland FGM
      is brought to trial as bodily injury. So far trials only in France and
      Switzerland in connection with FGM resulted in convictions. France and Great
      Britain as former Colonial countries serve as an example of countries with a
      comparably great number of African immigrants. These countries have the best
      possibilities to intervene preventatively, due to legislation and detailed
      medical guidelines. For instance, an obligation exists in France to inform
      administrative and medical authorities if FGM is suspected. FGM so far is not
      explicitly part of the curriculum for medical training in any of the examined
      countries.
FAU - Krasa, Kerstin
AU  - Krasa K
AD  - Institut fur Geschichte und Ethik der Medizin, Friedrich-Alexander-University
      Erlangen-Nuremberg, Glueckstr. 10, 91054, Erlangen, Germany.
      kerstin.krasa@ethik.med.uni-erlangen.de
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Med Health Care Philos
JT  - Medicine, health care, and philosophy
JID - 9815900
SB  - IM
MH  - Africa/ethnology
MH  - Circumcision, Female/adverse effects/*ethics/*legislation &
      jurisprudence/statistics & numerical data
MH  - Cross-Cultural Comparison
MH  - Emigrants and Immigrants/statistics & numerical data
MH  - Europe/epidemiology
MH  - Female
MH  - Germany/epidemiology
MH  - Human Rights Abuses/ethics/legislation & jurisprudence
MH  - Humans
MH  - Women's Rights/*ethics/*legislation & jurisprudence
EDAT- 2010/04/21 06:00
MHDA- 2010/12/21 06:00
CRDT- 2010/04/21 06:00
PHST- 2010/04/21 06:00 [entrez]
PHST- 2010/04/21 06:00 [pubmed]
PHST- 2010/12/21 06:00 [medline]
AID - 10.1007/s11019-010-9245-4 [doi]
PST - ppublish
SO  - Med Health Care Philos. 2010 Aug;13(3):269-78. doi: 10.1007/s11019-010-9245-4.


PMID- 20404625
OWN - NLM
STAT- MEDLINE
DCOM- 20100812
LR  - 20181201
IS  - 1538-9782 (Electronic)
IS  - 0887-6274 (Linking)
VI  - 24
IP  - 3
DP  - 2010 May-Jun
TI  - Health care providers' attitudes regarding family presence during resuscitation
      of adults: an integrated review of the literature.
PG  - 161-74
LID - 10.1097/NUR.0b013e3181dc548a [doi]
AB  - PURPOSE: Family presence (FP) during resuscitation is a controversial practice
      that leads to disagreement among health care professionals. A systematic review
      of the literature was performed to answer the question: What are the attitudes of
      health care providers regarding family presence during resuscitation of adults?
      METHODS: MEDLINE, PubMed, and CINAHL databases were searched using the following 
      terms: family, family presence, family witnessed, cardiopulmonary resuscitation, 
      nurses, personnel, patient, attitudes, attitude of health personnel, and ethics. 
      Criteria for inclusion consisted of research studies addressing health care
      providers' attitudes toward family presence during adult resuscitation conducted 
      in the United States that were published between 1998 and 2008. RESULTS: The
      literature search produced 480 titles. Thirteen full-text articles met criteria
      for inclusion in the evidence tables. Findings of this integrated literature
      indicate that: between and within discipline differences in attitudes, perceived 
      burden on staff, perceived effects on family, lack of medical knowledge of
      family, and existence of a hospital policy influence provider attitudes toward
      FP. CONCLUSIONS AND IMPLICATIONS: More research is needed to determine if FP is
      evidence based; however, there is sufficient evidence to consider implementing
      FP. There is wide variation in support for FP among health care professionals,
      although nurses generally are more favorable. If an institution elects to
      implement an FP policy or evidence-based practice guideline, it must carefully
      consider the many provider, patient, family, and system-level factors that can
      hinder or promote the success of this initiative.
FAU - Howlett, Mary Susan L
AU  - Howlett MS
AD  - Family Nurse Practitioner Program, University of Massachusetts, Boston,
      Massachusetts, USA. mhowlett@mnarn.org
FAU - Alexander, Gail A
AU  - Alexander GA
FAU - Tsuchiya, Brenda
AU  - Tsuchiya B
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
PL  - United States
TA  - Clin Nurse Spec
JT  - Clinical nurse specialist CNS
JID - 8709115
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Dissent and Disputes
MH  - Evidence-Based Practice
MH  - Family/*psychology
MH  - Humans
MH  - Nursing Methodology Research
MH  - Organizational Policy
MH  - Personnel, Hospital/education/*psychology
MH  - Practice Guidelines as Topic
MH  - Professional-Family Relations
MH  - Research Design
MH  - Resuscitation/nursing/*psychology
MH  - Social Support
MH  - United States
MH  - Visitors to Patients/education/*psychology
RF  - 21
EDAT- 2010/04/21 06:00
MHDA- 2010/08/13 06:00
CRDT- 2010/04/21 06:00
PHST- 2010/04/21 06:00 [entrez]
PHST- 2010/04/21 06:00 [pubmed]
PHST- 2010/08/13 06:00 [medline]
AID - 10.1097/NUR.0b013e3181dc548a [doi]
AID - 00002800-201005000-00010 [pii]
PST - ppublish
SO  - Clin Nurse Spec. 2010 May-Jun;24(3):161-74. doi: 10.1097/NUR.0b013e3181dc548a.


PMID- 20403636
OWN - NLM
STAT- MEDLINE
DCOM- 20100824
LR  - 20220408
IS  - 1873-7757 (Electronic)
IS  - 0145-2134 (Linking)
VI  - 34
IP  - 6
DP  - 2010 Jun
TI  - Vulnerable adolescent participants' experience in surveys on sexuality and sexual
      abuse: ethical aspects.
PG  - 438-47
LID - 10.1016/j.chiabu.2009.10.005 [doi]
AB  - OBJECTIVE: The aim of this research was to study the discomfort experienced by
      adolescents when answering questions in a survey about sexuality and sexual abuse
      and to investigate factors that may determine possible experience of discomfort. 
      The research focused particularly on vulnerable adolescents-sexually abused and
      sexually inexperienced. METHOD: Adolescents in their final year of high school in
      Estonia (n=1,334) and Sweden (n=3,401) who had completed a survey about
      experiences of sexuality and sexual abuse answered additional questions about
      experiences of discomfort related to the survey questions. RESULTS: A majority of
      the participants did not feel discomfort when completing the survey. This was
      also the case for the two vulnerable groups. Experience of penetrating sexual
      abuse, sexual inexperience, mental health problems, rape myth acceptance, gender,
      immigrant background, and country were included in a structural equation model.
      Experience of penetrating sexual abuse was not significantly related to
      discomfort in the final model, while sexual inexperience was associated with
      increased discomfort (standardized coefficient .20) and rape myth acceptance was 
      the strongest indicator of discomfort (.27). The total amount of explained
      variance was 17%. CONCLUSIONS: Our data do not support the view that adolescents 
      in general or vulnerable subgroups such as sexually abused or sexually
      inexperienced adolescents experience discomfort when answering a survey about
      sexuality and sexual abuse. As discomfort ratings were not highly related to any 
      of the predictors further research is needed that includes other factors. It is
      important to follow existing ethical guidelines since there may always be some
      individuals who feel discomfort.
CI  - Copyright 2010 Elsevier Ltd. All rights reserved.
FAU - Priebe, Gisela
AU  - Priebe G
AD  - Department of Child and Adolescent Psychiatry, Lund University, Sweden.
FAU - Backstrom, Martin
AU  - Backstrom M
FAU - Ainsaar, Mare
AU  - Ainsaar M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100418
PL  - England
TA  - Child Abuse Negl
JT  - Child abuse & neglect
JID - 7801702
SB  - IM
MH  - Adolescent
MH  - Child Abuse, Sexual/*psychology
MH  - Data Collection/*ethics
MH  - Estonia
MH  - Female
MH  - Humans
MH  - Male
MH  - *Sexuality
MH  - *Stress, Psychological
MH  - Sweden
MH  - Vulnerable Populations
EDAT- 2010/04/21 06:00
MHDA- 2010/08/25 06:00
CRDT- 2010/04/21 06:00
PHST- 2008/07/19 00:00 [received]
PHST- 2009/10/09 00:00 [revised]
PHST- 2009/10/15 00:00 [accepted]
PHST- 2010/04/21 06:00 [entrez]
PHST- 2010/04/21 06:00 [pubmed]
PHST- 2010/08/25 06:00 [medline]
AID - S0145-2134(10)00090-6 [pii]
AID - 10.1016/j.chiabu.2009.10.005 [doi]
PST - ppublish
SO  - Child Abuse Negl. 2010 Jun;34(6):438-47. doi: 10.1016/j.chiabu.2009.10.005. Epub 
      2010 Apr 18.


PMID- 20403304
OWN - NLM
STAT- MEDLINE
DCOM- 20101005
LR  - 20220317
IS  - 1818-6300 (Print)
IS  - 1818-6300 (Linking)
VI  - 11
IP  - 2
DP  - 2010 Apr
TI  - A comparison of paediatric dentists' and general dental practitioners' care
      patterns in paediatric dental care.
PG  - 93-6
AB  - AIM: The aim of this study was to compare the care patterns of paediatric
      dentists and general dentists in the dental treatment of children in the
      Netherlands. STUDY DESIGN AND METHODS: A case control study was completed based
      on the financial records of one of the largest Dutch health insurance companies. 
      After medical ethical approval the dental records from 2004, 2005 and 2006 of 16 
      paediatric dentists were used and compared with the records of general
      practitioners with the same number of insured paediatric patients from the same
      age and urbanisation level. Preventive, diagnostic and restorative care for four 
      consecutive age groups (<6, 6-8, 9-11, 12-17 yrs) were used as independent
      variables. Differences between the dentists and the age groups were tested with
      the Independent-Sample t-Test and ratios were calculated. RESULTS: Compared with 
      general dentists, paediatric dentists use statistically significant more often
      rubber-dam (p=0.009) and did more preventive treatments (p<0.001) in children up 
      to aged 11 yrs, more extractions (p<0.001), took more radiographs (p=0.027) and
      used local analgesia more often (p=0.002) in children until aged 8 yrs and
      performed more restorations (p=0.02) in children up to 6 yrs of age. There was no
      significant difference in the care pattern of the dentists for the oldest age
      group (12-17 yrs). The care-index for paediatric dentists and general dentists
      from this research was comparable with Dutch epidemiological studies. CONCLUSION:
      Compared with general dentists, paediatric dentists have a more extensive
      treatment approach when treating children. In the youngest age groups the
      differences are the most pronounced. Further studies are needed to clarify
      whether the cause is the needs of the patient or an attitude of supervised
      neglect by the general dentists.
FAU - Schorer-Jensma, M A
AU  - Schorer-Jensma MA
AD  - Department of Cariology, Endodontology and Paedodontology, Academic Centre of
      Dentistry Amsterdam [ACTA], EA Amsterdam, The Netherlands. m.jensma@acta.nl
FAU - Veerkamp, J S J
AU  - Veerkamp JS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Eur Arch Paediatr Dent
JT  - European archives of paediatric dentistry : official journal of the European
      Academy of Paediatric Dentistry
JID - 101277157
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Anesthesia, Dental/methods
MH  - Attitude of Health Personnel
MH  - Child
MH  - Child, Preschool
MH  - Dental Care for Children/*methods/statistics & numerical data
MH  - Dental Restoration, Permanent/statistics & numerical data
MH  - General Practice, Dental/*methods
MH  - Humans
MH  - Insurance, Dental
MH  - Netherlands
MH  - Pediatric Dentistry/*methods
MH  - Practice Patterns, Dentists'/*statistics & numerical data
MH  - Preventive Dentistry/statistics & numerical data
MH  - Radiography, Dental/statistics & numerical data
MH  - Retrospective Studies
MH  - Rubber Dams/statistics & numerical data
MH  - Tooth Extraction/statistics & numerical data
EDAT- 2010/04/21 06:00
MHDA- 2010/10/06 06:00
CRDT- 2010/04/21 06:00
PHST- 2010/04/21 06:00 [entrez]
PHST- 2010/04/21 06:00 [pubmed]
PHST- 2010/10/06 06:00 [medline]
AID - 09.39 [pii]
AID - 10.1007/BF03262719 [doi]
PST - ppublish
SO  - Eur Arch Paediatr Dent. 2010 Apr;11(2):93-6. doi: 10.1007/BF03262719.


PMID- 20403181
OWN - NLM
STAT- MEDLINE
DCOM- 20100730
LR  - 20220318
IS  - 1476-4598 (Electronic)
IS  - 1476-4598 (Linking)
VI  - 9
DP  - 2010 Apr 19
TI  - Quantitative proteomics identification of phosphoglycerate mutase 1 as a novel
      therapeutic target in hepatocellular carcinoma.
PG  - 81
LID - 10.1186/1476-4598-9-81 [doi]
AB  - BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most common malignancies
      worldwide with poor prognosis due to resistance to conventional chemotherapy and 
      limited efficacy of radiotherapy. There is an urgent need to develop novel
      biomarkers for early diagnosis, as well as to identify new drug targets for
      therapeutic interventions. PATIENTS AND METHODS: 54 paired HCC samples and 21
      normal liver tissues were obtained from West China Hospital of Sichuan
      University. Informed consent was obtained from all the patients or their
      relatives prior to analysis, and the project was approved by the Institutional
      Ethics Committee of Sichuan University. Stable Isotope Labeling with Amino Acids 
      in Cell Culture (SILAC)-based proteomics was employed to profile the
      differentially expressed proteins between a HepG2 human hepatoma cell line and an
      immortal hepatic cell line L02. Validation of PGAM1 expression was performed by
      semi-quantitative RT-PCR, immunoblot and immunohistochemistry using clinical
      samples. shRNA expressing plasmids specifically targeting PGAM1 were designed and
      constructed by GenePharma Corporation (Shanghai, China), and were utilized to
      silence expression of PGAM1 in vitro and in vivo. Cell proliferation was measured
      by a combination of colony formation assay and Ki67 staining. Apoptosis was
      examined by flow cytometry and TUNEL assay. RESULTS: A total of 63 dysregulated
      proteins were identified, including 51 up-regulated proteins, and 12
      down-regulated proteins (over 2-fold, p < 0.01). Phosphoglycerate mutase 1
      (PGAM1) was found markedly upregulated. Clinico-pathological analysis indicated
      that overexpression of PGAM1 was associated with 66.7% HCC, and strongly
      correlated with poor differentiation and decreased survival rates (p < 0.01).
      shRNAs-mediated repression of PGAM1 expression resulted in significant inhibition
      in liver cancer cell growth both in vitro and in vivo. CONCLUSION: Our studies
      suggested that PGAM1 plays an important role in hepatocarcinogenesis, and should 
      be a potential diagnostic biomarker, as well as an attractive therapeutic target 
      for hepatocellular carcinoma.
FAU - Ren, Fenglian
AU  - Ren F
AD  - The State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 
      Chengdu, China.
FAU - Wu, Hong
AU  - Wu H
FAU - Lei, Yunlong
AU  - Lei Y
FAU - Zhang, Haiyuan
AU  - Zhang H
FAU - Liu, Rui
AU  - Liu R
FAU - Zhao, Yong
AU  - Zhao Y
FAU - Chen, Xiancheng
AU  - Chen X
FAU - Zeng, Dequan
AU  - Zeng D
FAU - Tong, Aiping
AU  - Tong A
FAU - Chen, Lijuan
AU  - Chen L
FAU - Wei, Yuquan
AU  - Wei Y
FAU - Huang, Canhua
AU  - Huang C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100419
PL  - England
TA  - Mol Cancer
JT  - Molecular cancer
JID - 101147698
RN  - 0 (Biomarkers, Tumor)
RN  - EC 5.4.2.11 (Phosphoglycerate Mutase)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Biomarkers, Tumor/*analysis
MH  - Blotting, Western
MH  - Carcinoma, Hepatocellular/*genetics/metabolism/pathology
MH  - Cell Separation
MH  - Female
MH  - Flow Cytometry
MH  - *Gene Expression Profiling
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Nick-End Labeling
MH  - Liver Neoplasms/*genetics/metabolism/pathology
MH  - Mice
MH  - Mice, Nude
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Phosphoglycerate Mutase/biosynthesis/*genetics
MH  - Proteomics/methods
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Xenograft Model Antitumor Assays
PMC - PMC2873438
EDAT- 2010/04/21 06:00
MHDA- 2010/07/31 06:00
CRDT- 2010/04/21 06:00
PHST- 2009/11/09 00:00 [received]
PHST- 2010/04/19 00:00 [accepted]
PHST- 2010/04/21 06:00 [entrez]
PHST- 2010/04/21 06:00 [pubmed]
PHST- 2010/07/31 06:00 [medline]
AID - 1476-4598-9-81 [pii]
AID - 10.1186/1476-4598-9-81 [doi]
PST - epublish
SO  - Mol Cancer. 2010 Apr 19;9:81. doi: 10.1186/1476-4598-9-81.


PMID- 20401499
OWN - NLM
STAT- MEDLINE
DCOM- 20100823
LR  - 20161125
IS  - 0942-0940 (Electronic)
IS  - 0001-6268 (Linking)
VI  - 152
IP  - 6
DP  - 2010 Jun
TI  - Skull base training and education using an artificial skull model created by
      selective laser sintering.
PG  - 1055-59; discussion 1059-60
LID - 10.1007/s00701-010-0624-7 [doi]
AB  - INTRODUCTION: Practicing skull base approaches on cadavers affords the surgeon a 
      chance to learn complex anatomical relationships and to practice surgical skills.
      However, there are ethical or legal problems in obtaining cadaver material in
      some countries. In addition, there is always risk of transmitting infections with
      cadaveric material. In order to get around these problems, we created a whole
      skull model which reproduces the detailed anatomy within the skull base using a
      selective laser sintering (SLS) technique. MATERIALS AND METHODS: The first
      author's head was scanned using multidetector-row computed tomography. The data
      were reconstructed and converted into the standard triangulation language file
      system. Powdered material comprised of polyamide nylon and glass beads was
      laser-sintered in accord with the data derived from the head CT. The model was
      dissected under a surgical microscope using a high-speed drill, suction, and
      other surgical instruments. RESULTS AND DISCUSSION: The appearance of both inner 
      and outer cranial surfaces, including sutures, foramens, fissures, and
      protrusions, were clearly demonstrated. The artificial mastoid did not melt from 
      the heat of the drill when a mastoidectomy was performed. The anatomical
      structures inside the mastoid and of paranasal sinuses were accurately reproduced
      in the model. CONCLUSION: The model created using SLS should be very useful for
      the teaching skull base approaches avoiding the ethical, legal, and infection
      problems inherent in cadavers.
FAU - Wanibuchi, Masahiko
AU  - Wanibuchi M
AD  - Department of Neurosurgery, School of Medicine, Sapporo Medical University,
      South-1, West-16, Sapporo, Hokkaido 060-8543, Japan. wanibuti@sapmed.ac.jp
FAU - Ohtaki, Masafumi
AU  - Ohtaki M
FAU - Fukushima, Takanori
AU  - Fukushima T
FAU - Friedman, Allan H
AU  - Friedman AH
FAU - Houkin, Kiyohiro
AU  - Houkin K
LA  - eng
PT  - Journal Article
DEP - 20100418
PL  - Austria
TA  - Acta Neurochir (Wien)
JT  - Acta neurochirurgica
JID - 0151000
RN  - 0 (Resins, Synthetic)
SB  - IM
MH  - Computer-Aided Design
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Imaging, Three-Dimensional
MH  - Lasers
MH  - Microsurgery
MH  - *Models, Anatomic
MH  - Neurosurgery/*education
MH  - Resins, Synthetic
MH  - Skull Base/*anatomy & histology/diagnostic imaging/*surgery
MH  - Tomography, Spiral Computed
EDAT- 2010/04/20 06:00
MHDA- 2010/08/24 06:00
CRDT- 2010/04/20 06:00
PHST- 2009/12/24 00:00 [received]
PHST- 2010/02/24 00:00 [accepted]
PHST- 2010/04/20 06:00 [entrez]
PHST- 2010/04/20 06:00 [pubmed]
PHST- 2010/08/24 06:00 [medline]
AID - 10.1007/s00701-010-0624-7 [doi]
PST - ppublish
SO  - Acta Neurochir (Wien). 2010 Jun;152(6):1055-59; discussion 1059-60. doi:
      10.1007/s00701-010-0624-7. Epub 2010 Apr 18.


PMID- 20401439
OWN - NLM
STAT- MEDLINE
DCOM- 20101216
LR  - 20190606
IS  - 1414-431X (Electronic)
IS  - 0100-879X (Linking)
VI  - 43
IP  - 3
DP  - 2010 Mar
TI  - Cardiac and pulmonary alterations in symptomatic and asymptomatic dogs infected
      naturally with Leishmania (Leishmania) chagasi.
PG  - 310-5
LID - S0100-879X2010000300014 [pii]
AB  - Fifteen symptomatic and seven asymptomatic dogs infected naturally with
      Leishmania chagasi were examined in order to identify the presence of parasites
      and changes in heart and lung. Histopathological, cytological, and
      immunohistochemical analyses were performed on samples of heart and lung tissues.
      An inflammatory reaction characterized by inflammatory mononuclear, perivascular 
      and intermuscular infiltrates was observed in both symptomatic and asymptomatic
      animals on histopathological analysis of the heart. In the lung, there was
      thickening of the alveolar septa due to congestion, edema, inflammatory
      infiltrate, and fibroblast proliferation. A focal reaction was observed although 
      a diffuse reaction was present in both groups. On cytological examination, heart 
      and lung imprints revealed amastigotes in two symptomatic animals and heart
      imprints were found in 1 asymptomatic dog. Immunoperoxidase staining showed
      amastigotes in the lung and heart of only 1 of 6 symptomatic animals examined.
      Within the ethical principles and limits of this research, it can be inferred
      that the study of heart and lung alterations in canine visceral leishmaniasis is 
      increasingly important for understanding the problem related to humans. Dogs with
      visceral leishmaniasis were a good experimental model, since infection was caused
      by the same agent and the animals developed clinical, pathological and
      immunological alterations similar to those observed in humans.
FAU - Alves, G B B
AU  - Alves GB
AD  - Universidade Federal do Piaui, Teresina, PI, Brasil.
FAU - Pinho, F A
AU  - Pinho FA
FAU - Silva, S M M S
AU  - Silva SM
FAU - Cruz, M S P
AU  - Cruz MS
FAU - Costa, F A L
AU  - Costa FA
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - Braz J Med Biol Res
JT  - Brazilian journal of medical and biological research = Revista brasileira de
      pesquisas medicas e biologicas
JID - 8112917
RN  - 0 (Antibodies, Protozoan)
SB  - IM
MH  - Animals
MH  - Antibodies, Protozoan/blood
MH  - Dog Diseases/diagnosis/*pathology
MH  - Dogs
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Fluorescent Antibody Technique, Indirect
MH  - Immunohistochemistry
MH  - *Leishmania infantum/immunology
MH  - Leishmaniasis, Visceral/diagnosis/pathology/*veterinary
MH  - Lung/*parasitology/pathology
MH  - Male
MH  - Myocardium/*pathology
EDAT- 2010/04/20 06:00
MHDA- 2010/12/17 06:00
CRDT- 2010/04/20 06:00
PHST- 2009/07/25 00:00 [received]
PHST- 2010/01/04 00:00 [accepted]
PHST- 2010/04/20 06:00 [entrez]
PHST- 2010/04/20 06:00 [pubmed]
PHST- 2010/12/17 06:00 [medline]
AID - S0100-879X2010000300014 [pii]
AID - 10.1590/s0100-879x2009007500037 [doi]
PST - ppublish
SO  - Braz J Med Biol Res. 2010 Mar;43(3):310-5. doi: 10.1590/s0100-879x2009007500037.


PMID- 20401357
OWN - NLM
STAT- MEDLINE
DCOM- 20100722
LR  - 20140730
IS  - 1064-6655 (Print)
IS  - 1064-6655 (Linking)
VI  - 24
IP  - 2
DP  - 2010 Spring
TI  - Prediction of postoperative pain after mandibular third molar surgery.
PG  - 189-96
AB  - AIMS: To evaluate the predictive potential of preoperative psychological and
      psychophysiological variables in estimating severity of postoperative pain
      following mandibular third molar surgery (MTMS). METHODS: Following ethical
      committee approval and informed consent, 40 consecutive patients scheduled for
      MTMS were included. Preoperative psychometric indicators of anxiety, depression, 
      and vulnerability were evaluated by patient questionnaires. Thermal thresholds
      and heat pain perception (1 second phasic stimuli: 44 degrees C to 48 degrees C) 
      were evaluated with quantitative sensory testing techniques. Standardized surgery
      was performed during local anesthesia. Postoperative pain management was with
      rescue paracetamol and ibuprofen. The patients were instructed to record each day
      their pain at rest and during dynamic conditions, and their requirement of
      analgesics for 14 days following surgery. RESULTS: Thirty-eight patients
      completed the study. Eight patients were readmitted because of pain. During the
      postoperative period, one or more episodes of moderate to severe pain (> 30 on a 
      visual analog scale) was reported by 60% (23/38) at rest, 63% (24/38) during
      mouth-opening, and 73% (28/38) during eating. In a multiple regression model, the
      combination of psychological vulnerability and heat pain perception rendered a
      predictive model that could account for 15 to 30% of the variance in
      postoperative pain during resting and dynamic conditions (P = .03 to .001).
      CONCLUSION: Implementation of clinically relevant preoperative screening methods 
      may offer more efficacious postoperative pain therapies to pain-susceptible
      individuals undergoing mandibular third molar surgery. J Orofac Pain
      2010;24:189-196.
FAU - Rudin, Asa
AU  - Rudin A
AD  - Department of Anesthesiology and Intensive Care, Lund University Hospital, S-221 
      85 Lund, Sweden. asa.rudin@skane.se
FAU - Eriksson, Lars
AU  - Eriksson L
FAU - Liedholm, Rolf
AU  - Liedholm R
FAU - List, Thomas
AU  - List T
FAU - Werner, Mads U
AU  - Werner MU
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Orofac Pain
JT  - Journal of orofacial pain
JID - 9418507
RN  - 0 (Analgesics, Non-Narcotic)
RN  - 362O9ITL9D (Acetaminophen)
RN  - WK2XYI10QM (Ibuprofen)
MH  - Acetaminophen/therapeutic use
MH  - Adult
MH  - Analgesics, Non-Narcotic/therapeutic use
MH  - Anxiety/classification/psychology
MH  - Attitude
MH  - Depression/classification/psychology
MH  - Eating/physiology
MH  - Female
MH  - Follow-Up Studies
MH  - Forecasting
MH  - Humans
MH  - Ibuprofen/therapeutic use
MH  - Male
MH  - Mandible/*surgery
MH  - Molar, Third/*surgery
MH  - Pain Measurement
MH  - Pain Threshold/physiology
MH  - Pain, Postoperative/*classification/psychology
MH  - Range of Motion, Articular/physiology
MH  - Sensory Thresholds/physiology
MH  - Temperature
MH  - Time Factors
MH  - *Tooth Extraction
MH  - Tooth, Unerupted/surgery
EDAT- 2010/04/20 06:00
MHDA- 2010/07/23 06:00
CRDT- 2010/04/20 06:00
PHST- 2010/04/20 06:00 [entrez]
PHST- 2010/04/20 06:00 [pubmed]
PHST- 2010/07/23 06:00 [medline]
PST - ppublish
SO  - J Orofac Pain. 2010 Spring;24(2):189-96.


PMID- 20400375
OWN - NLM
STAT- MEDLINE
DCOM- 20101220
LR  - 20100601
IS  - 1472-6491 (Electronic)
IS  - 1472-6483 (Linking)
VI  - 20
IP  - 7
DP  - 2010 Jun
TI  - The ethical debate on donor insemination in China.
PG  - 895-902
LID - 10.1016/j.rbmo.2010.01.014 [doi]
AB  - This article gives an overview of the ethical thinking about donor insemination
      among Chinese ethicists. We analysed the ethical arguments dedicated to the use
      of donor spermatozoa published in the important bioethics journals of China of
      the last 15 years. On the one hand, the general Confucian values strongly favour 
      the genetic link as it fits with the traditional importance attached to the
      continuation of the family line. Therefore, artificial insemination by donor
      (AID) is highly controversial in China because the involvement of a third party
      (the donor) severs the genetic link between the husband and his family. On the
      other hand, procreation is regarded as an important aspect of Confucian filial
      piety and it is a basic right of every human being to enjoy a family life. AID
      should be thought of as a means to help infertile couples to overcome
      infertility. Nowadays, Chinese bioethicists are trying to reinterpret
      Confucianism in order to adapt it to modernity. One such reinterpretation focuses
      on the affectionate rather than the genetic tie between parents and child. As the
      application is still new in China, more discussion and open debate on ethical
      aspects is needed.
CI  - Copyright 2010 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights
      reserved.
FAU - Liao, Juhong
AU  - Liao J
AD  - Bioethics Institute Ghent, Ghent University, Belgium. juhong.liao@ugent.be
FAU - Dessein, Bart
AU  - Dessein B
FAU - Pennings, Guido
AU  - Pennings G
LA  - eng
PT  - Journal Article
DEP - 20100201
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
SB  - IM
MH  - China
MH  - Confucianism
MH  - Humans
MH  - Insemination, Artificial, Heterologous/economics/*ethics
MH  - Male
MH  - Sperm Banks/economics/ethics
MH  - Tissue Donors
MH  - Truth Disclosure/ethics
EDAT- 2010/04/20 06:00
MHDA- 2010/12/21 06:00
CRDT- 2010/04/20 06:00
PHST- 2009/11/17 00:00 [received]
PHST- 2010/01/18 00:00 [revised]
PHST- 2010/01/26 00:00 [accepted]
PHST- 2010/04/20 06:00 [entrez]
PHST- 2010/04/20 06:00 [pubmed]
PHST- 2010/12/21 06:00 [medline]
AID - S1472-6483(10)00050-7 [pii]
AID - 10.1016/j.rbmo.2010.01.014 [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2010 Jun;20(7):895-902. doi: 10.1016/j.rbmo.2010.01.014.
      Epub 2010 Feb 1.


PMID- 20400269
OWN - NLM
STAT- MEDLINE
DCOM- 20101020
LR  - 20160526
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Linking)
VI  - 120
IP  - 1-3
DP  - 2010 Jul
TI  - Probably at-risk, but certainly ill--advocating the introduction of a psychosis
      spectrum disorder in DSM-V.
PG  - 23-37
LID - 10.1016/j.schres.2010.03.015 [doi]
AB  - Current criteria for an increased risk of developing first-episode psychosis are 
      associated with conversion rates many times higher than the general incidence of 
      psychosis. Yet, non-conversions still outnumber conversions, and conversion rates
      across and within centres vary considerably, fueling the ongoing debate about
      clinical and ethical justification of indicated prevention. This debate, however,
      almost exclusively focuses on the predictive validity of at-risk criteria,
      thereby widely disregarding the main general finding: persons meeting at-risk
      criteria already suffer from multiple mental and functional disturbances for
      those they seek help. Moreover, they exhibit various psychological and cognitive 
      deficits along with morphological and functional cerebral changes. Thereby, the
      majority of help-seeking at-risk persons fulfils DSM-IV's general criteria for
      mental disorders (defined as a clinically significant behavioural or
      psychological syndrome associated with disability and/or severe distress) and
      clearly have to be considered as 'ill', i.e., as 'patients' with a need and right
      for treatment. Hence, the clinical picture defined by current at-risk criteria
      should be more adequately perceived as not only a still insufficient attempt to
      define the psychotic prodrome but a psychosis spectrum disorder in its own right 
      - akin to ICD-10's schizotypal disorder - with conversion to psychosis just being
      one of several outcomes. Such a disorder, whose criteria are proposed and
      discussed, should initially be part of DSM-V research criteria. Following from
      this shift in the perception of current at-risk criteria, access to standard
      medical care would have to be granted, and diagnosis- or symptom- rather than
      conversion-related interventions would have to be developed.
CI  - (c) 2010 Elsevier B.V. All rights reserved.
FAU - Ruhrmann, Stephan
AU  - Ruhrmann S
AD  - Department of Psychiatry and Psychotherapy, University of Cologne, Cologne,
      Germany. stephan.ruhrmann@uk-koeln.de
FAU - Schultze-Lutter, Frauke
AU  - Schultze-Lutter F
FAU - Klosterkotter, Joachim
AU  - Klosterkotter J
LA  - eng
PT  - Journal Article
DEP - 20100418
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - *Diagnostic and Statistical Manual of Mental Disorders
MH  - Humans
MH  - International Classification of Diseases
MH  - Mental Disorders/*diagnosis/*epidemiology/prevention & control
MH  - Predictive Value of Tests
MH  - Psychiatric Status Rating Scales
MH  - Reproducibility of Results
MH  - Risk Assessment/methods
MH  - Risk Factors
MH  - Schizotypal Personality Disorder/diagnosis/epidemiology
MH  - Sensitivity and Specificity
EDAT- 2010/04/20 06:00
MHDA- 2010/10/21 06:00
CRDT- 2010/04/20 06:00
PHST- 2009/10/09 00:00 [received]
PHST- 2010/03/08 00:00 [revised]
PHST- 2010/03/12 00:00 [accepted]
PHST- 2010/04/20 06:00 [entrez]
PHST- 2010/04/20 06:00 [pubmed]
PHST- 2010/10/21 06:00 [medline]
AID - S0920-9964(10)01185-0 [pii]
AID - 10.1016/j.schres.2010.03.015 [doi]
PST - ppublish
SO  - Schizophr Res. 2010 Jul;120(1-3):23-37. doi: 10.1016/j.schres.2010.03.015. Epub
      2010 Apr 18.


PMID- 20399354
OWN - NLM
STAT- MEDLINE
DCOM- 20100511
LR  - 20191210
IS  - 1558-1373 (Electronic)
IS  - 0030-5898 (Linking)
VI  - 41
IP  - 2
DP  - 2010 Apr
TI  - Challenges of randomized controlled surgical trials.
PG  - 145-55
LID - 10.1016/j.ocl.2009.11.001 [doi]
AB  - The concept of evidence-based medicine has gained broad support in the medical
      community, because clinical decisions based on information from rigorous
      scientific study are most likely to provide optimal care. Researchers attempt to 
      answer clinical questions using either observational studies or randomized
      controlled trials (RCTs). Observational studies currently dominate the surgical
      literature but provide a level of evidence inferior to RCTs. RCTs are ethically
      grounded in clinical equipoise and may further reduce the potential for bias or
      other confounding factors by blinding. This article discusses the barriers to
      implementation of surgical RCTs.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Campbell, Angela J
AU  - Campbell AJ
AD  - Department of Orthopaedics, Shriners Hospitals for Children, Northern California,
      2425 Stockton Boulevard, Sacramento, CA 95817, USA.
FAU - Bagley, Anita
AU  - Bagley A
FAU - Van Heest, Ann
AU  - Van Heest A
FAU - James, Michelle A
AU  - James MA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Orthop Clin North Am
JT  - The Orthopedic clinics of North America
JID - 0254463
SB  - IM
MH  - Evidence-Based Medicine
MH  - Humans
MH  - *Orthopedic Procedures
MH  - Outcome Assessment, Health Care
MH  - *Randomized Controlled Trials as Topic/methods/standards
MH  - Selection Bias
EDAT- 2010/04/20 06:00
MHDA- 2010/05/12 06:00
CRDT- 2010/04/20 06:00
PHST- 2010/04/20 06:00 [entrez]
PHST- 2010/04/20 06:00 [pubmed]
PHST- 2010/05/12 06:00 [medline]
AID - S0030-5898(09)00106-0 [pii]
AID - 10.1016/j.ocl.2009.11.001 [doi]
PST - ppublish
SO  - Orthop Clin North Am. 2010 Apr;41(2):145-55. doi: 10.1016/j.ocl.2009.11.001.


PMID- 20399070
OWN - NLM
STAT- MEDLINE
DCOM- 20101029
LR  - 20161209
IS  - 2213-0276 (Electronic)
IS  - 0755-4982 (Linking)
VI  - 39
IP  - 9
DP  - 2010 Sep
TI  - [Frequency and type of gifts given by pharmaceutical industry to cardiology
      residents].
PG  - e197-204
LID - 10.1016/j.lpm.2009.11.017 [doi]
AB  - OBJECTIVE: Cardiovascular diseases are the leading cause of death in the world
      and cardiologists are an important target for the pharmaceutical industry. We
      evaluated cardiology residents' exposure to pharmaceutical companies. METHODS: A 
      survey was sent by e-mail in July 2009 to all residents of the Cardiology and
      Vascular Diseases program endorsed by the French Society of Cardiology. RESULTS: 
      The questionnaire was completed by 149 (56%) residents. Among them, 145 (97%) had
      at least one promotional item in their white coat. Non-educational gifts (such as
      pens and notepads) and scientific papers reprints are the most frequently
      received gifts. Pharmaceutical companies have invited 117 (79%) residents to a
      local or national congress and 42 (29%) to an international congress. Most
      residents consider gifts as ethically appropriate, particularly scientific
      textbooks, invitations to congresses and educational seminars. Among the 128
      residents who assessed the value of a gift likely to compromise a physician's
      judgment, 36 (28%) answered < 100 euro, 51 (40%) between 101 and 1000 euro and 41
      (32%) >1000 euro. CONCLUSIONS: Cardiology residents in France frequently interact
      with the pharmaceutical industry, receiving not only small gifts but also support
      to their medical education. Interactions with industry are generally considered
      appropriate and training on their ethical implications and influence on
      prescribing could be implemented during residency.
CI  - Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
FAU - Moubarak, Ghassan
AU  - Moubarak G
AD  - Service de cardiologie, Hopital Lariboisiere, 75010 Paris, France.
      ghassan.moubarak@gmail.com
FAU - Martins, Raphael Pedro
AU  - Martins RP
FAU - Zuily, Stephane
AU  - Zuily S
FAU - Mechulan, Alexis
AU  - Mechulan A
FAU - Guiot, Aurelie
AU  - Guiot A
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Frequence et type de cadeaux recus par les internes de cardiologie de la part de 
      l'industrie pharmaceutique.
DEP - 20100415
PL  - France
TA  - Presse Med
JT  - Presse medicale (Paris, France : 1983)
JID - 8302490
SB  - IM
MH  - Adult
MH  - *Cardiology
MH  - Drug Industry/*statistics & numerical data
MH  - Female
MH  - *Gift Giving
MH  - Humans
MH  - *Internship and Residency
MH  - Male
MH  - Surveys and Questionnaires
EDAT- 2010/04/20 06:00
MHDA- 2010/10/30 06:00
CRDT- 2010/04/20 06:00
PHST- 2009/08/27 00:00 [received]
PHST- 2009/11/03 00:00 [revised]
PHST- 2009/11/20 00:00 [accepted]
PHST- 2010/04/20 06:00 [entrez]
PHST- 2010/04/20 06:00 [pubmed]
PHST- 2010/10/30 06:00 [medline]
AID - S0755-4982(10)00168-5 [pii]
AID - 10.1016/j.lpm.2009.11.017 [doi]
PST - ppublish
SO  - Presse Med. 2010 Sep;39(9):e197-204. doi: 10.1016/j.lpm.2009.11.017. Epub 2010
      Apr 15.


PMID- 20398303
OWN - NLM
STAT- MEDLINE
DCOM- 20100726
LR  - 20211020
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 11
DP  - 2010 Apr 15
TI  - The Health Informatics Trial Enhancement Project (HITE): Using routinely
      collected primary care data to identify potential participants for a depression
      trial.
PG  - 39
LID - 10.1186/1745-6215-11-39 [doi]
AB  - BACKGROUND: Recruitment to clinical trials can be challenging. We identified
      anonymous potential participants to an existing pragmatic randomised controlled
      depression trial to assess the feasibility of using routinely collected data to
      identify potential trial participants. We discuss the strengths and limitations
      of this approach, assess its potential value, report challenges and ethical
      issues encountered. METHODS: Swansea University's Health Information Research
      Unit's Secure Anonymised Information Linkage (SAIL) database of routinely
      collected health records was interrogated, using Structured Query Language (SQL).
      Read codes were used to create an algorithm of inclusion/exclusion criteria with 
      which to identify suitable anonymous participants. Two independent clinicians
      rated the eligibility of the potential participants' identified. Inter-rater
      reliability was assessed using the kappa statistic and inter-class correlation.
      RESULTS: The study population (N = 37263) comprised all adults registered at five
      general practices in Swansea UK. Using the algorithm 867 anonymous potential
      participants were identified. The sensitivity and specificity results > 0.9
      suggested a high degree of accuracy from the algorithm. The inter-rater
      reliability results indicated strong agreement between the confirming raters. The
      Intra Class Correlation Coefficient (Cronbach's Alpha) > 0.9, suggested excellent
      agreement and Kappa coefficient > 0.8; almost perfect agreement. CONCLUSIONS:
      This proof of concept study showed that routinely collected primary care data can
      be used to identify potential participants for a pragmatic randomised controlled 
      trial of folate augmentation of antidepressant therapy for the treatment of
      depression. Further work will be needed to assess generalisability to other
      conditions and settings and the inclusion of this approach to support Electronic 
      Enhanced Recruitment (EER).
FAU - McGregor, Joanna
AU  - McGregor J
AD  - Centre for Health Information Research and Evaluation (CHIRAL), School of
      Medicine, Grove Building, Swansea University, Singleton Park, Swansea, UK.
FAU - Brooks, Caroline
AU  - Brooks C
FAU - Chalasani, Padmaja
AU  - Chalasani P
FAU - Chukwuma, Jude
AU  - Chukwuma J
FAU - Hutchings, Hayley
AU  - Hutchings H
FAU - Lyons, Ronan A
AU  - Lyons RA
FAU - Lloyd, Keith
AU  - Lloyd K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100415
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
RN  - 0 (Antidepressive Agents)
RN  - 12001-76-2 (Vitamin B Complex)
RN  - 935E97BOY8 (Folic Acid)
SB  - IM
MH  - Adult
MH  - Algorithms
MH  - Antidepressive Agents/*therapeutic use
MH  - Depression/*drug therapy
MH  - Drug Therapy, Combination
MH  - Feasibility Studies
MH  - Female
MH  - Folic Acid/*therapeutic use
MH  - Humans
MH  - Male
MH  - *Medical Informatics
MH  - *Medical Records Systems, Computerized
MH  - Observer Variation
MH  - *Patient Selection
MH  - *Primary Health Care
MH  - *Randomized Controlled Trials as Topic
MH  - Reproducibility of Results
MH  - Vitamin B Complex/*therapeutic use
MH  - Wales
PMC - PMC2864261
EDAT- 2010/04/20 06:00
MHDA- 2010/07/27 06:00
CRDT- 2010/04/20 06:00
PHST- 2009/10/21 00:00 [received]
PHST- 2010/04/15 00:00 [accepted]
PHST- 2010/04/20 06:00 [entrez]
PHST- 2010/04/20 06:00 [pubmed]
PHST- 2010/07/27 06:00 [medline]
AID - 1745-6215-11-39 [pii]
AID - 10.1186/1745-6215-11-39 [doi]
PST - epublish
SO  - Trials. 2010 Apr 15;11:39. doi: 10.1186/1745-6215-11-39.


PMID- 20397928
OWN - NLM
STAT- MEDLINE
DCOM- 20110113
LR  - 20211020
IS  - 1557-8534 (Electronic)
IS  - 1547-3287 (Linking)
VI  - 19
IP  - 8
DP  - 2010 Aug
TI  - Alternative sources of pluripotent stem cells: ethical and scientific issues
      revisited.
PG  - 1121-9
LID - 10.1089/scd.2009.0482 [doi]
AB  - Stem cell researchers in the United States continue to face an uncertain future, 
      because of the changing federal guidelines governing this research, the
      restrictive patent situation surrounding the generation of new human embryonic
      stem cell lines, and the ethical divide over the use of embryos for research. In 
      this commentary, we describe how recent advances in the derivation of induced
      pluripotent stem cells and the isolation of germ-line-derived pluripotent stem
      cells resolve a number of these uncertainties. The availability of
      patient-matched, pluripotent stem cells that can be obtained by ethically
      acceptable means provides important advantages for stem cell researchers, by both
      avoiding protracted ethical debates and giving U.S. researchers full access to
      federal funding. Thus, ethically uncompromised stem cells, such as those derived 
      by direct reprogramming or from germ-cell precursors, are likely to yield
      important advances in stem cell research and move the field rapidly toward
      clinical applications.
FAU - Condic, Maureen L
AU  - Condic ML
AD  - Department of Neurobiology and Anatomy, University of Utah School of Medicine,
      Salt Lake City, Utah 84132-3401, USA. mlcondic@neuro.utah.edu
FAU - Rao, Mahendra
AU  - Rao M
LA  - eng
GR  - R01 NS048382/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United States
TA  - Stem Cells Dev
JT  - Stem cells and development
JID - 101197107
SB  - IM
MH  - Animals
MH  - Embryonic Stem Cells/cytology
MH  - Germ Cells/cytology
MH  - Humans
MH  - Induced Pluripotent Stem Cells/cytology
MH  - Pluripotent Stem Cells/*cytology
MH  - Stem Cell Research/economics/*ethics/legislation & jurisprudence
PMC - PMC3128309
EDAT- 2010/04/20 06:00
MHDA- 2011/01/14 06:00
CRDT- 2010/04/20 06:00
PHST- 2010/04/20 06:00 [entrez]
PHST- 2010/04/20 06:00 [pubmed]
PHST- 2011/01/14 06:00 [medline]
AID - 10.1089/scd.2009.0482 [doi]
PST - ppublish
SO  - Stem Cells Dev. 2010 Aug;19(8):1121-9. doi: 10.1089/scd.2009.0482.


PMID- 20397875
OWN - NLM
STAT- MEDLINE
DCOM- 20100730
LR  - 20211020
IS  - 1532-2491 (Electronic)
IS  - 1082-6084 (Linking)
VI  - 45
IP  - 6
DP  - 2010 May
TI  - Organizational issues in the implementation of a hospital-based syringe exchange 
      program.
PG  - 901-15
LID - 10.3109/10826080903080631 [doi]
AB  - Little published information exists to guide health care institutions in
      establishing syringe exchange program (SEP) services. To address this gap, this
      article discusses organizational issues encountered in the implementation of a
      hospital-based SEP in San Francisco, California (USA). Investigators collaborated
      with a community organization in implementing a county hospital-based SEP. SEP
      services integrated into a public hospital presented unique challenges directly
      related to their status as a health care institution. In the course of
      introducing SEP services into a hospital setting as part of a clinical trial,
      various ethical, legal, and logistical issues were raised. Based on these
      experiences, this paper provides guidance on how to integrate an SEP into a
      traditional health care institution.
FAU - Masson, Carmen L
AU  - Masson CL
AD  - Department of Psychiatry, San Francisco General Hospital Center, University of
      California, San Francisco, California 94110, USA. Carmen.masson@ucsf.edu
FAU - Sorensen, James L
AU  - Sorensen JL
FAU - Grossman, Nina
AU  - Grossman N
FAU - Sporer, Karl A
AU  - Sporer KA
FAU - Des Jarlais, Don C
AU  - Des Jarlais DC
FAU - Perlman, David C
AU  - Perlman DC
LA  - eng
GR  - P30 DA011041/DA/NIDA NIH HHS/United States
GR  - P50 DA009253/DA/NIDA NIH HHS/United States
GR  - P30DA011041/DA/NIDA NIH HHS/United States
GR  - P50DA09253/DA/NIDA NIH HHS/United States
GR  - K01 DA000408/DA/NIDA NIH HHS/United States
GR  - K01DA000408/DA/NIDA NIH HHS/United States
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - Subst Use Misuse
JT  - Substance use & misuse
JID - 9602153
SB  - IM
MH  - Community Networks/history
MH  - HIV Infections
MH  - History, 20th Century
MH  - History, 21st Century
MH  - *Hospitals, Public
MH  - Humans
MH  - Needle-Exchange Programs/ethics/legislation & jurisprudence/*organization &
      administration
MH  - *Program Development/methods
MH  - San Francisco
MH  - Substance Abuse, Intravenous
PMC - PMC3378397
MID - NIHMS371981
EDAT- 2010/04/20 06:00
MHDA- 2010/07/31 06:00
CRDT- 2010/04/20 06:00
PHST- 2010/04/20 06:00 [entrez]
PHST- 2010/04/20 06:00 [pubmed]
PHST- 2010/07/31 06:00 [medline]
AID - 10.3109/10826080903080631 [doi]
PST - ppublish
SO  - Subst Use Misuse. 2010 May;45(6):901-15. doi: 10.3109/10826080903080631.


PMID- 20397765
OWN - NLM
STAT- MEDLINE
DCOM- 20100617
LR  - 20181201
IS  - 1651-226X (Electronic)
IS  - 0284-186X (Linking)
VI  - 49
IP  - 3
DP  - 2010 Apr
TI  - The prostate cancer pseudo-epidemic.
PG  - 298-304
LID - 10.3109/02841860903584945 [doi]
AB  - Screening for prostate cancer with prostate-specific antigen (PSA), a simple
      blood test, is complex, controversial, intellectually challenging and ethically
      concerning. Sweden has contributed actively to the knowledge base for PSA
      screening in the last couple of years and a more informed debate is now possible.
      I will in this article summarize what we currently know about PSA testing. I
      discuss the closely related issues of the natural history of early-stage disease 
      and the risks and benefits of radical local treatment. I propose that the
      mortality reduction following PSA screening is probably modest, whilst
      substantial harms are well documented. Furthermore, there is growing evidence
      that the PSA test is profoundly limited for screening purposes. I therefore
      concur with the growing number of health and professional agencies - notably
      outside the US - that advise against population screening with PSA. Through PSA
      screening the medical community has generated a pseudo-epidemic of over-diagnosed
      non-lethal prostate cancer. Molecular tools to distinguish innocent,
      over-diagnosed prostate cancer from lethal tumors that deserving curative
      treatment are necessary to improve screening test performance. To date, extensive
      attempts to identify molecular predictors of outcome have remained unsuccessful, 
      and no ideal screening test is within sight.
FAU - Adami, Hans-Olov
AU  - Adami HO
AD  - Department of Epidemiology, Harvard School of Public Health, 677 Huntington
      Avenue, Boston, Massachusetts 02115, USA. Adami@hsph.harvard.edu
LA  - eng
PT  - Lecture
PL  - England
TA  - Acta Oncol
JT  - Acta oncologica (Stockholm, Sweden)
JID - 8709065
RN  - 0 (Biomarkers, Tumor)
RN  - EC 3.4.21.77 (Prostate-Specific Antigen)
SB  - IM
CIN - Acta Oncol. 2010 Apr;49(3):275-7. PMID: 20397764
MH  - Biomarkers, Tumor/*blood
MH  - *Disease Outbreaks
MH  - Europe/epidemiology
MH  - Evidence-Based Medicine
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Incidence
MH  - Male
MH  - *Mass Screening/adverse effects/methods
MH  - Neoplasm Staging
MH  - Predictive Value of Tests
MH  - Prevalence
MH  - Prostate-Specific Antigen/*blood
MH  - Prostatic
      Neoplasms/*diagnosis/*epidemiology/immunology/mortality/pathology/therapy
MH  - Risk Assessment
MH  - Sensitivity and Specificity
MH  - Sweden/epidemiology
MH  - Uncertainty
MH  - United States/epidemiology
EDAT- 2010/04/20 06:00
MHDA- 2010/06/18 06:00
CRDT- 2010/04/20 06:00
PHST- 2010/04/20 06:00 [entrez]
PHST- 2010/04/20 06:00 [pubmed]
PHST- 2010/06/18 06:00 [medline]
AID - 10.3109/02841860903584945 [doi]
PST - ppublish
SO  - Acta Oncol. 2010 Apr;49(3):298-304. doi: 10.3109/02841860903584945.


PMID- 20397736
OWN - NLM
STAT- MEDLINE
DCOM- 20100709
LR  - 20211020
IS  - 1179-1942 (Electronic)
IS  - 0114-5916 (Linking)
VI  - 33
IP  - 5
DP  - 2010 May 1
TI  - Development safety update reports and proposals for effective and efficient risk 
      communication.
PG  - 341-52
LID - 10.2165/11533780-000000000-00000 [doi]
AB  - The periodic safety reporting to regulatory authorities is globally harmonized
      for postmarketing medicinal products by the International Conference on
      Harmonisation (ICH) guidelines, and is being extended for investigational drugs. 
      To facilitate effective safety risk communication regarding investigational
      drugs, and to reduce duplicate periodic reporting to the US and EU by sponsors
      during development programmes, standardized Development Safety Update Reports
      (DSURs) are to be implemented in the near future. In this current opinion
      article, after extensively reviewing the relevant report from the CIOMS VII
      Working Group and the ICH draft guideline regarding DSURs, we discuss an
      effective and efficient approach to its application. To ensure effective risk
      communication, we recommend that DSURs be made available to all the ethics
      committees and participating investigators around the world for the purpose of
      continuing review during ongoing clinical trials. Furthermore, in order to
      maintain the consistency and integrity of safety information throughout the
      life-cycle of a drug, we believe it would be substantially more prudent and
      efficient to start a single, integrated, life-cycle periodic safety report
      covering both development and postmarketing, as proposed by the CIOMS VII Working
      Group, rather than maintain separate DSURs and Periodic Safety Update Reports,
      which can overlap considerably in content. To this end, we believe that the
      international regulatory community should undertake the new initiative for
      integrated periodic reporting immediately.
FAU - Urushihara, Hisashi
AU  - Urushihara H
AD  - Department of Pharmacoepidemiology, Graduate School of Medicine and Public
      Health, Kyoto University, Kyoto, Japan.
FAU - Kawakami, Koji
AU  - Kawakami K
LA  - eng
PT  - Journal Article
PL  - New Zealand
TA  - Drug Saf
JT  - Drug safety
JID - 9002928
RN  - 0 (Drugs, Investigational)
SB  - IM
MH  - Adverse Drug Reaction Reporting Systems/organization & administration
MH  - Communication
MH  - Drug Approval/*methods
MH  - Drug-Related Side Effects and Adverse Reactions
MH  - Drugs, Investigational/*adverse effects
MH  - Humans
MH  - Product Surveillance, Postmarketing/methods
MH  - Risk Assessment
EDAT- 2010/04/20 06:00
MHDA- 2010/07/10 06:00
CRDT- 2010/04/20 06:00
PHST- 2010/04/20 06:00 [entrez]
PHST- 2010/04/20 06:00 [pubmed]
PHST- 2010/07/10 06:00 [medline]
AID - 1 [pii]
AID - 10.2165/11533780-000000000-00000 [doi]
PST - ppublish
SO  - Drug Saf. 2010 May 1;33(5):341-52. doi: 10.2165/11533780-000000000-00000.


PMID- 20397040
OWN - NLM
STAT- MEDLINE
DCOM- 20101029
LR  - 20220331
IS  - 1573-6601 (Electronic)
IS  - 0047-2891 (Linking)
VI  - 39
IP  - 7
DP  - 2010 Jul
TI  - The Five Cs model of positive youth development: a longitudinal analysis of
      confirmatory factor structure and measurement invariance.
PG  - 720-35
LID - 10.1007/s10964-010-9530-9 [doi]
AB  - The understanding of positive development across adolescence rests on having a
      valid and equivalent measure of this construct across the breadth of this period 
      of life. Does the Positive Youth Development (PYD) construct based on the Five Cs
      model have satisfactory psychometric properties for such longitudinal measurement
      invariance? Using longitudinal data derived from the 4-H Study of PYD, we
      assessed 920 youth (61.6% female) from a racially and ethically diverse sample
      (67.3% European American) who participated in three waves (Grades 8-10) of data
      collection. Building on prior findings that the Five Cs (i.e., Competence,
      Confidence, Connection, Character, and Caring) model of PYD was a robust measure 
      that could be assessed comparably during early adolescence, we tested a hierarchy
      of second-order confirmatory factor analysis models to assess the extent to which
      PYD can be measured equivalently across middle adolescence. Evidence was found
      for strict measurement invariance across three measurement occasions, including
      equivalence of first-order and second-order factor loadings, equality of
      intercepts of observed variables, and equality of item uniqueness and
      disturbances of the first-order factors. These results suggest that PYD can be
      measured in the same way across measurement occasions, a prerequisite for the
      study of development. Implications for research and application of being able to 
      measure PYD equivalently across adolescence are discussed.
FAU - Bowers, Edmond P
AU  - Bowers EP
AD  - Institute for Applied Research in Youth Development, Tufts University, 307
      Lincoln-Filene Building, Medford, MA, 02155, USA. Ed.Bowers@tufts.edu
FAU - Li, Yibing
AU  - Li Y
FAU - Kiely, Megan K
AU  - Kiely MK
FAU - Brittian, Aerika
AU  - Brittian A
FAU - Lerner, Jacqueline V
AU  - Lerner JV
FAU - Lerner, Richard M
AU  - Lerner RM
LA  - eng
PT  - Journal Article
DEP - 20100416
PL  - United States
TA  - J Youth Adolesc
JT  - Journal of youth and adolescence
JID - 0333507
SB  - IM
MH  - Adolescent
MH  - *Adolescent Development
MH  - *Affect
MH  - Factor Analysis, Statistical
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - *Personality Assessment
MH  - Surveys and Questionnaires
EDAT- 2010/04/17 06:00
MHDA- 2010/10/30 06:00
CRDT- 2010/04/17 06:00
PHST- 2009/12/21 00:00 [received]
PHST- 2010/03/27 00:00 [accepted]
PHST- 2010/04/17 06:00 [entrez]
PHST- 2010/04/17 06:00 [pubmed]
PHST- 2010/10/30 06:00 [medline]
AID - 10.1007/s10964-010-9530-9 [doi]
PST - ppublish
SO  - J Youth Adolesc. 2010 Jul;39(7):720-35. doi: 10.1007/s10964-010-9530-9. Epub 2010
      Apr 16.


PMID- 20396371
OWN - NLM
STAT- MEDLINE
DCOM- 20110526
LR  - 20171116
IS  - 1671-167X (Print)
IS  - 1671-167X (Linking)
VI  - 42
IP  - 2
DP  - 2010 Apr 18
TI  - [Cervical cancer associated with pregnancy: 2 cases report].
PG  - 231-3
AB  - Cervical cancer is the first malignant disease of the women all over the world.
      Although the incidence of cervical cancer has been decreasing due to increased
      availability of screening tests, the diagnosis, management and prognosis of
      pregnancy associated with cervical cancer are still complex problems for clinical
      doctors. Here we report two cases of pregnancy associated with cervical cancer in
      our hospital and analyze the screening tests, the management, the neoadjuvant
      chemotherapy and the prognosis of the cases. Besides, we also review some
      literature and conclude by relating with our case reports that: cervical
      cytological test is significant for the prenatal examination and doing the test
      can obviously decrease the incidence of cervical cancer for pregnant women; In
      the clinical process, the doctors should take the social, ethical, medical
      condition etc. into account in the management for each trimester at presentation;
      The neoadjuvant chemotherapy has become a blessing for the pregnant women
      associated with cervical cancer and there is no bad result reported in the
      literature; The main factor influencing prognosis of pregnancy associated with
      cervical cancer is in the tumor stage.
FAU - Shan, Xue-min
AU  - Shan XM
AD  - Department of Genecology and Obstetrics, Peking University First Hospital,
      Beijing 100034, China. shan-shan-929@sohu.com
FAU - Hu, Jun
AU  - Hu J
FAU - Zhu, Li-rong
AU  - Zhu LR
LA  - chi
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Beijing Da Xue Xue Bao Yi Xue Ban
JT  - Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health
      sciences
JID - 101125284
SB  - IM
MH  - Adult
MH  - Carcinoma, Squamous Cell/*diagnosis/drug therapy/surgery
MH  - Cervical Intraepithelial Neoplasia/*diagnosis/drug therapy/surgery
MH  - Female
MH  - Humans
MH  - Pregnancy
MH  - Pregnancy Complications, Neoplastic/*diagnosis/drug therapy/surgery
MH  - Uterine Cervical Neoplasms/*diagnosis/drug therapy/surgery
EDAT- 2010/04/17 06:00
MHDA- 2011/05/27 06:00
CRDT- 2010/04/17 06:00
PHST- 2010/04/17 06:00 [entrez]
PHST- 2010/04/17 06:00 [pubmed]
PHST- 2011/05/27 06:00 [medline]
PST - ppublish
SO  - Beijing Da Xue Xue Bao Yi Xue Ban. 2010 Apr 18;42(2):231-3.


PMID- 20395871
OWN - NLM
STAT- MEDLINE
DCOM- 20110217
LR  - 20161125
IS  - 1536-0237 (Electronic)
IS  - 0883-5993 (Linking)
VI  - 25
IP  - 4
DP  - 2010 Nov
TI  - Gravitational gradients in expiratory computed tomography examinations of
      patients with small airways disease: effect of body position on extent of air
      trapping.
PG  - 311-9
LID - 10.1097/RTI.0b013e3181cbc28b [doi]
AB  - PURPOSE: First, to test the hypothesis that air trapping in diseased patients
      follows a gravitational gradient and is more extensive in dependent than in
      nondependent lung regions. Second, to test the hypothesis that the dependent lung
      regions on combined supine and prone expiratory computed tomography (CT)
      examinations will show more air trapping than would a supine expiratory CT
      examination alone. MATERIALS AND METHODS: For this ethics committee-approved
      study, supine and prone multidetector-row CT (4x1 mm collimation, 0.5 s rotation 
      time, 140 kVp, and effective 80 mAs) was performed at full end-expiration on 47
      lung transplant recipients (mean age 41+/-12 y; 18 without bronchiolitis, 18 with
      potential bronchiolitis, and 11 with bronchiolitis). The extent of air trapping
      was visually quantified in the supine and prone positions, and in dependent and
      nondependent lung regions. Individual air trapping scores from these regions were
      thus available and could be combined for later analysis. Differences in the
      extent of air trapping between the positions and regions were tested with a
      Wilcoxon signed-rank test. RESULTS: Air trapping was significantly more extensive
      in the combined dependent lung regions than in the combined nondependent lung
      regions (15.00% vs. 5.77%; P<0.001). Air trapping was also significantly more
      extensive in the combined dependent regions than in the supine body position
      (15.00% vs. 7.50%; P<0.001). No statistically significant difference in the
      extent of air trapping was found between the supine and the prone positions
      (7.50% vs. 12.14%; P=0.735). CONCLUSIONS: In patients with suspected or overt
      small airways disease, air trapping follows a gravitational gradient. A change
      from the supine to the prone position can make air trapping visible in formerly
      nondependent lung regions. The combined readings from supine and prone CT
      examinations in dependent lung regions show more air trapping than a standard
      supine CT examination alone.
FAU - Bankier, Alexander A
AU  - Bankier AA
AD  - Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA 02215, 
      USA. abankier@bidmc.harvard.edu
FAU - Estenne, Marc
AU  - Estenne M
FAU - Kienzl, Daniela
AU  - Kienzl D
FAU - Muller-Mang, Christina
AU  - Muller-Mang C
FAU - Van Muylem, Alain
AU  - Van Muylem A
FAU - Gevenois, Pierre Alain
AU  - Gevenois PA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Thorac Imaging
JT  - Journal of thoracic imaging
JID - 8606160
SB  - IM
MH  - Adult
MH  - Air
MH  - Bronchiolitis Obliterans/*diagnostic imaging
MH  - Exhalation
MH  - Female
MH  - *Gravitation
MH  - Humans
MH  - Image Processing, Computer-Assisted/methods
MH  - Lung/diagnostic imaging
MH  - Lung Transplantation
MH  - Male
MH  - Middle Aged
MH  - Observer Variation
MH  - *Posture
MH  - Prone Position
MH  - Prospective Studies
MH  - Respiratory Function Tests
MH  - Supine Position
MH  - Tomography, X-Ray Computed/*methods
MH  - Young Adult
EDAT- 2010/04/17 06:00
MHDA- 2011/02/18 06:00
CRDT- 2010/04/17 06:00
PHST- 2010/04/17 06:00 [entrez]
PHST- 2010/04/17 06:00 [pubmed]
PHST- 2011/02/18 06:00 [medline]
AID - 10.1097/RTI.0b013e3181cbc28b [doi]
PST - ppublish
SO  - J Thorac Imaging. 2010 Nov;25(4):311-9. doi: 10.1097/RTI.0b013e3181cbc28b.


PMID- 20395693
OWN - NLM
STAT- MEDLINE
DCOM- 20100727
LR  - 20220309
IS  - 1662-8063 (Electronic)
IS  - 1662-4246 (Linking)
VI  - 13
IP  - 4
DP  - 2010
TI  - Non-invasive prenatal diagnosis using cell-free fetal DNA technology:
      applications and implications.
PG  - 246-55
LID - 10.1159/000279626 [doi]
AB  - Cell-free fetal DNA and RNA circulating in maternal blood can be used for the
      early non-invasive prenatal diagnosis (NIPD) of an increasing number of genetic
      conditions, both for pregnancy management and to aid reproductive
      decision-making. Here we present a brief review of the scientific and clinical
      status of the technology, and an overview of key ethical, legal and social issues
      raised by the analysis of cell-free fetal DNA for NIPD. We suggest that the less 
      invasive nature of the technology brings some distinctive issues into focus, such
      as the possibility of broader uptake of prenatal diagnosis and access to the
      technology directly by the consumer via the internet, which have not been
      emphasised in previous work in this area. We also revisit significant issues that
      are familiar from previous debates about prenatal testing. Since the technology
      seems to transect existing distinctions between screening and diagnostic tests,
      there are important implications for the form and process involved in obtaining
      informed consent or choice. This analysis forms part of the work undertaken by a 
      multidisciplinary group of experts which made recommendations about the
      implementation of this technology within the UK National Health Service.
CI  - Copyright 2010 S. Karger AG, Basel.
FAU - Hall, Alison
AU  - Hall A
AD  - PHG Foundation, Cambridge, UK. alison.hall@phgfoundation.org
FAU - Bostanci, A
AU  - Bostanci A
FAU - Wright, C F
AU  - Wright CF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100415
PL  - Switzerland
TA  - Public Health Genomics
JT  - Public health genomics
JID - 101474167
RN  - 0 (Genetic Markers)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - DNA/*analysis
MH  - Ethics, Medical
MH  - Female
MH  - Fetal Diseases/*diagnosis/genetics
MH  - Fetus
MH  - Genetic Markers
MH  - Genetic Testing/*ethics/*methods
MH  - Humans
MH  - Informed Consent
MH  - Pregnancy
MH  - Prenatal Diagnosis/*ethics/*methods
RF  - 69
EDAT- 2010/04/17 06:00
MHDA- 2010/07/28 06:00
CRDT- 2010/04/17 06:00
PHST- 2010/04/17 06:00 [entrez]
PHST- 2010/04/17 06:00 [pubmed]
PHST- 2010/07/28 06:00 [medline]
AID - 000279626 [pii]
AID - 10.1159/000279626 [doi]
PST - ppublish
SO  - Public Health Genomics. 2010;13(4):246-55. doi: 10.1159/000279626. Epub 2010 Apr 
      15.


PMID- 20395689
OWN - NLM
STAT- MEDLINE
DCOM- 20100727
LR  - 20211020
IS  - 1662-8063 (Electronic)
IS  - 1662-4246 (Linking)
VI  - 13
IP  - 4
DP  - 2010
TI  - The value of using top-down and bottom-up approaches for building trust and
      transparency in biobanking.
PG  - 207-14
LID - 10.1159/000279622 [doi]
AB  - With the domestic and international proliferation of biobanks and their
      associated connections to health information databases, scholarly attention has
      been turning from the ethical issues arising from the construction of biobanks to
      the ethical issues that emerge in their operation and management. Calls for
      greater transparency in governance structures, coupled with stern reminders of
      the value of maintaining public trust, are seen as critical components in the
      success of these resources. Two different approaches have been adopted for
      addressing these types of ethical issues: the first is a 'top-down' approach
      which focuses on developing policy, procedures, regulations and guidelines to aid
      decision-makers. The second is a 'bottom-up' approach, which begins with those
      who are most affected by the issues and attempts to inductively develop consensus
      recommendations and policy. While both approaches have merit, I argue that more
      work needs to be done on 'bottom-up' strategies if trust and transparency are to 
      be more than mere slogans. Using 2 case examples from Indiana, the paper
      summarizes data from a set of surveys we recently conducted that address issues
      arising from biobanks that provide some insight into issues associated with trust
      and transparency.
CI  - Copyright 2010 S. Karger AG, Basel.
FAU - Meslin, Eric M
AU  - Meslin EM
AD  - Indiana University Center for Bioethics, Indiana University School of Medicine,
      Indianapolis, Ind. 46202, USA. emeslin@iupui.edu
LA  - eng
GR  - UL1 RR025761/RR/NCRR NIH HHS/United States
GR  - UL1RR025761-01/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20100415
PL  - Switzerland
TA  - Public Health Genomics
JT  - Public health genomics
JID - 101474167
SB  - IM
MH  - *Bioethics
MH  - Biomedical Research/ethics/legislation & jurisprudence
MH  - Community Participation
MH  - Health Policy
MH  - Humans
MH  - Indiana
MH  - Information Dissemination/ethics
MH  - Public Health
MH  - Public Opinion
MH  - Tissue Banks/*ethics/*legislation & jurisprudence
MH  - *Trust
MH  - Truth Disclosure/ethics
PMC - PMC2865393
EDAT- 2010/04/17 06:00
MHDA- 2010/07/28 06:00
CRDT- 2010/04/17 06:00
PHST- 2010/04/17 06:00 [entrez]
PHST- 2010/04/17 06:00 [pubmed]
PHST- 2010/07/28 06:00 [medline]
AID - 000279622 [pii]
AID - 10.1159/000279622 [doi]
PST - ppublish
SO  - Public Health Genomics. 2010;13(4):207-14. doi: 10.1159/000279622. Epub 2010 Apr 
      15.


PMID- 20395688
OWN - NLM
STAT- MEDLINE
DCOM- 20100727
LR  - 20220408
IS  - 1662-8063 (Electronic)
IS  - 1662-4246 (Linking)
VI  - 13
IP  - 4
DP  - 2010
TI  - Structuring public engagement for effective input in policy development on human 
      tissue biobanking.
PG  - 197-206
LID - 10.1159/000279621 [doi]
AB  - We begin with the premise that human tissue biobanking is associated with ethical
      ambiguities and regulatory uncertainty, and that public engagement is at least
      one important element in addressing such challenges. One is then confronted with 
      how to achieve public engagement that is both meaningful and effective. In
      particular, how can public engagement on the topic of biobanking be implemented
      so that (a) it is perceived broadly as legitimate and (b) the results of the
      engagement are relevant and useful to the institutional and regulatory context?
      In this paper we build on previous work that has addressed the former point and
      focus primarily on the latter. We argue that one way to increase the likelihood
      of results of public engagement being taken up in policy is through framing the
      issues that are deliberated by members of the public based in part on the
      practical policy questions for which input is sought. In this approach, we move
      discussion on the social and ethical implications of biobanking from abstract
      principles, to their consideration in the context of local biobanking practices. 
      This is illustrated using a practical example involving a public engagement
      conducted to inform institutional policy for biobanking in British Columbia,
      Canada.
CI  - Copyright 2010 S. Karger AG, Basel.
FAU - O'Doherty, Kieran C
AU  - O'Doherty KC
AD  - W. Maurice Young Centre for Applied Ethics, University of British Columbia,
      Vancouver, B.C., Canada. kcodoher@interchange.ubc.ca
FAU - Hawkins, A
AU  - Hawkins A
LA  - eng
GR  - 92675/CAPMC/ CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100415
PL  - Switzerland
TA  - Public Health Genomics
JT  - Public health genomics
JID - 101474167
SB  - IM
MH  - Bioethics
MH  - Biomedical Research/ethics
MH  - Community Participation
MH  - Female
MH  - Genomics/*methods
MH  - Global Health
MH  - Government Regulation
MH  - Humans
MH  - Informed Consent/ethics
MH  - Male
MH  - Public Health/*methods
MH  - Public Opinion
MH  - Tissue Banks/*ethics
PMC - PMC2874727
MID - CAMS815
OID - NLM: CAMS815
EDAT- 2010/04/17 06:00
MHDA- 2010/07/28 06:00
CRDT- 2010/04/17 06:00
PHST- 2010/04/17 06:00 [entrez]
PHST- 2010/04/17 06:00 [pubmed]
PHST- 2010/07/28 06:00 [medline]
AID - 000279621 [pii]
AID - 10.1159/000279621 [doi]
PST - ppublish
SO  - Public Health Genomics. 2010;13(4):197-206. doi: 10.1159/000279621. Epub 2010 Apr
      15.


PMID- 20395568
OWN - NLM
STAT- MEDLINE
DCOM- 20100524
LR  - 20211020
IS  - 1541-0048 (Electronic)
IS  - 0090-0036 (Linking)
VI  - 100
IP  - 6
DP  - 2010 Jun
TI  - Ethical imperative of posttrial access to antiretroviral treatment.
PG  - 966-7; author reply 967
LID - 10.2105/AJPH.2009.186288 [doi]
FAU - Onyeabor, Onyekachi Sunny
AU  - Onyeabor OS
LA  - eng
PT  - Comment
PT  - Letter
DEP - 20100415
PL  - United States
TA  - Am J Public Health
JT  - American journal of public health
JID - 1254074
RN  - 0 (Anti-HIV Agents)
SB  - IM
CON - Am J Public Health. 2009 Sep;99(9):1556-62. PMID: 19608940
MH  - Anti-HIV Agents/*therapeutic use
MH  - Clinical Trials as Topic/*ethics
MH  - Developing Countries
MH  - HIV Infections/*drug therapy
MH  - Health Services Accessibility/*ethics
MH  - Humans
PMC - PMC2866584
EDAT- 2010/04/17 06:00
MHDA- 2010/05/25 06:00
CRDT- 2010/04/17 06:00
PHST- 2010/04/17 06:00 [entrez]
PHST- 2010/04/17 06:00 [pubmed]
PHST- 2010/05/25 06:00 [medline]
AID - AJPH.2009.186288 [pii]
AID - 10.2105/AJPH.2009.186288 [doi]
PST - ppublish
SO  - Am J Public Health. 2010 Jun;100(6):966-7; author reply 967. doi:
      10.2105/AJPH.2009.186288. Epub 2010 Apr 15.


PMID- 20394241
OWN - NLM
STAT- MEDLINE
DCOM- 20100706
LR  - 20190911
IS  - 0080-6234 (Print)
IS  - 0080-6234 (Linking)
VI  - 44
IP  - 1
DP  - 2010 Mar
TI  - [Obstetrical nurses' perceptions of their competence in assisting hospital
      delivery].
PG  - 213-20
AB  - The perception that obstetrical nurses have of their competence in assisting
      hospital deliveries has been investigated in this qualitative study. Data
      collection was performed through individual semi-structured interviews at a
      university hospital in Porto Alegre, and was then submitted to content analysis. 
      The analyses were grounded on frameworks that define professional competence as
      the ability to mobilize different kinds of knowledge, depending on the practice
      problems to be solved. The obstetrical nurses understand competence in attending 
      hospital deliveries as something multidimensional, although they have emphasized 
      its technical dimension. This emphasis is justified through insecurity resulting 
      from a lack of space to provide nursing care to hospital delivery, due both to
      disputes with physicians and to deficiencies in nurses' training. The desire to
      be competent in providing care during hospital deliveries has not been translated
      into awareness of their responsibilities in changing that scenario. This suggests
      that in order to act towards those desired changes, it would be necessary to
      develop not only technical but also ethical-political competence.
FAU - Rabelo, Leila Regina
AU  - Rabelo LR
AD  - Faculdade de Enfermagem da Universidade do Vale do Rio dos Sinos, Brasil.
      leilarabelo@terra.com.br
FAU - de Oliveira, Dora Lucia
AU  - de Oliveira DL
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Percepcoes de enfermeiras obstetricas sobre sua competencia na atencao ao parto
      normal hospitalar.
PL  - Brazil
TA  - Rev Esc Enferm USP
JT  - Revista da Escola de Enfermagem da U S P
JID - 0242726
MH  - *Clinical Competence
MH  - *Obstetric Nursing
EDAT- 2010/04/17 06:00
MHDA- 2010/07/07 06:00
CRDT- 2010/04/17 06:00
PHST- 2010/04/17 06:00 [entrez]
PHST- 2010/04/17 06:00 [pubmed]
PHST- 2010/07/07 06:00 [medline]
AID - S0080-62342010000100030 [pii]
AID - 10.1590/s0080-62342010000100030 [doi]
PST - ppublish
SO  - Rev Esc Enferm USP. 2010 Mar;44(1):213-20. doi: 10.1590/s0080-62342010000100030.


PMID- 20394235
OWN - NLM
STAT- MEDLINE
DCOM- 20100706
LR  - 20190911
IS  - 0080-6234 (Print)
IS  - 0080-6234 (Linking)
VI  - 44
IP  - 1
DP  - 2010 Mar
TI  - [Prejudice in nursing: perception of nurses educated in different decades].
PG  - 166-73
AB  - The objective of this qualitative study, of a historical-social nature, was to
      learn and understand the perceptions of a group of nurses, who graduated in
      different decades, regarding the prejudice and forms of coping involved in
      choosing the profession, during their university studies, or in professional
      practice. Oral Life History and content analysis were used. The EEUSP Research
      Ethics Committee approved this study. The following categories were obtained from
      the subjects' statements: prejudicial attitudes when choosing nursing as a
      career; prejudice noticed during the course of nursing education; and prejudice
      experienced within professional practice. Regarding the forms of coping,
      collaborators reported that dissemination of information about nursing is
      important, as is skillful practice and teamwork. This study contributed to a
      better understanding regarding ways of confronting situations concerning
      prejudice, thus making it possible to seek strategies for social recognition and 
      appreciation of the profession.
FAU - Jesus, Elaine dos Santos
AU  - Jesus Edos S
AD  - Escola de Enfermagem, Universidade de Sao Paulo, Sao Paulo, SP, Brasil.
      elainesj3@usp.br
FAU - Marques, Leona Rei
AU  - Marques LR
FAU - Assis, Luana Conceicao Fortes
AU  - Assis LC
FAU - Alves, Taisy Becerra
AU  - Alves TB
FAU - de Freitas, Genival Fernandez
AU  - de Freitas GF
FAU - Oguisso, Taka
AU  - Oguisso T
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Preconceito na enfermagem: percepcao de enfermeiros formados em diferentes
      decadas.
PL  - Brazil
TA  - Rev Esc Enferm USP
JT  - Revista da Escola de Enfermagem da U S P
JID - 0242726
MH  - Female
MH  - Humans
MH  - Male
MH  - *Nursing
MH  - *Prejudice
MH  - Time Factors
EDAT- 2010/04/17 06:00
MHDA- 2010/07/07 06:00
CRDT- 2010/04/17 06:00
PHST- 2010/04/17 06:00 [entrez]
PHST- 2010/04/17 06:00 [pubmed]
PHST- 2010/07/07 06:00 [medline]
AID - S0080-62342010000100024 [pii]
AID - 10.1590/s0080-62342010000100024 [doi]
PST - ppublish
SO  - Rev Esc Enferm USP. 2010 Mar;44(1):166-73. doi: 10.1590/s0080-62342010000100024.


PMID- 20394108
OWN - NLM
STAT- MEDLINE
DCOM- 20100714
LR  - 20191111
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 24
IP  - 4
DP  - 2010 May
TI  - Are moral philosophers moral experts?
PG  - 153-9
AB  - In this paper I examine the question of whether ethicists are moral experts. I
      call people moral experts if their moral judgments are correct with high
      probability and for the right reasons. I defend three theses, while developing a 
      version of the coherence theory of moral justification based on the differences
      between moral and nonmoral experience: The answer to the question of whether
      there are moral experts depends on the answer to the question of how to justify
      moral judgments. Deductivism and the coherence theory both provide some support
      for the opinion that moral experts exist in some way. I maintain - within the
      framework of a certain kind of coherence theory - that moral philosophers are
      'semi-experts'.
FAU - Gesang, Bernward
AU  - Gesang B
AD  - Philosophisches Institut, University of Duesseldorf, Universitaetstr. 1,
      Duesseldorf 40225, Germany. gesangbe@gmx.de
LA  - eng
PT  - Journal Article
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Ethical Theory
MH  - *Ethicists
MH  - Humans
MH  - *Morals
MH  - *Philosophy
MH  - *Professional Competence
EDAT- 2010/04/16 06:00
MHDA- 2010/07/16 06:00
CRDT- 2010/04/16 06:00
PHST- 2010/04/16 06:00 [entrez]
PHST- 2010/04/16 06:00 [pubmed]
PHST- 2010/07/16 06:00 [medline]
AID - 10.1111/j.1467-8519.2008.00691.x [doi]
PST - ppublish
SO  - Bioethics. 2010 May;24(4):153-9. doi: 10.1111/j.1467-8519.2008.00691.x.


PMID- 20393719
OWN - NLM
STAT- MEDLINE
DCOM- 20110112
LR  - 20211020
IS  - 1432-1084 (Electronic)
IS  - 0938-7994 (Linking)
VI  - 20
IP  - 9
DP  - 2010 Sep
TI  - Non-invasive tracking of human haemopoietic CD34(+) stem cells in vivo in
      immunodeficient mice by using magnetic resonance imaging.
PG  - 2184-93
LID - 10.1007/s00330-010-1773-z [doi]
AB  - OBJECTIVE: To assess migration of CD34(+) human stem cells to the bone marrow of 
      athymic mice by using magnetic resonance (MR) imaging and Resovist, a contrast
      agent containing superparamagnetic iron oxide (SPIO) particles. METHODS: All
      animal and human procedures were approved by our institution's ethics committee, 
      and women had given consent to donate umbilical cord blood (UCB). Balb/c-AnN
      Foxn1(nu)/Crl mice received intravenous injection of 1 x 10(6) (n=3), 5 x 10(6)
      (n=3) or 1 x 10(7) (n=3) human Resovist-labelled CD34(+) cells; control mice
      received Resovist (n=3). MR imaging was performed before, 2 and 24 h after
      transplantation. Signal intensities of liver, muscle and bone marrow were
      measured and analysed by ANOVA and post hoc Student's t tests. MR imaging data
      were verified by histological and immunological detection of both human cell
      surface markers and carboxydextrancoating of the contrast agent. RESULTS: CD34(+)
      cells were efficiently labelled by Resovist without impairment of functionality. 
      Twenty-four hours after administration of labelled cells, MR imaging revealed a
      significant signal decline in the bone marrow, and histological and immunological
      analyses confirmed the presence of transplanted human CD34(+) cells. CONCLUSION: 
      Intravenously administered Resovist-labelled CD34(+) cells home to bone marrow of
      mice. Homing can be tracked in vivo by using clinical 1.5-T MR imaging
      technology.
FAU - Niemeyer, Markus
AU  - Niemeyer M
AD  - Department of Gynaecology, Klinikum rechts der Isar, Technische Universitat
      Munchen, Ismaninger Str. 22, 81675 Munich, Germany. markus.niemeyer@gmx.net
FAU - Oostendorp, Robert A J
AU  - Oostendorp RA
FAU - Kremer, Markus
AU  - Kremer M
FAU - Hippauf, Sandra
AU  - Hippauf S
FAU - Jacobs, Volker R
AU  - Jacobs VR
FAU - Baurecht, Hansjorg
AU  - Baurecht H
FAU - Ludwig, Georg
AU  - Ludwig G
FAU - Piontek, Guido
AU  - Piontek G
FAU - Bekker-Ruz, Viktoria
AU  - Bekker-Ruz V
FAU - Timmer, Sebastian
AU  - Timmer S
FAU - Rummeny, Ernst J
AU  - Rummeny EJ
FAU - Kiechle, Marion
AU  - Kiechle M
FAU - Beer, Ambros J
AU  - Beer AJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Eur Radiol
JT  - European radiology
JID - 9114774
RN  - 0 (Contrast Media)
RN  - 0 (Dextrans)
RN  - 0 (Magnetite Nanoparticles)
RN  - G6N3J05W84 (ferumoxides)
SB  - IM
MH  - Animals
MH  - Cell Tracking/*methods
MH  - Cells, Cultured
MH  - Common Variable Immunodeficiency/*immunology/*pathology/surgery
MH  - Contrast Media
MH  - *Dextrans
MH  - Female
MH  - Hematopoietic Stem Cell Transplantation/*methods
MH  - Humans
MH  - Immunocompromised Host/*immunology
MH  - Magnetic Resonance Imaging/*methods
MH  - *Magnetite Nanoparticles
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Nude
MH  - Staining and Labeling/methods
EDAT- 2010/04/16 06:00
MHDA- 2011/01/13 06:00
CRDT- 2010/04/16 06:00
PHST- 2009/08/31 00:00 [received]
PHST- 2010/02/05 00:00 [accepted]
PHST- 2010/02/04 00:00 [revised]
PHST- 2010/04/16 06:00 [entrez]
PHST- 2010/04/16 06:00 [pubmed]
PHST- 2011/01/13 06:00 [medline]
AID - 10.1007/s00330-010-1773-z [doi]
PST - ppublish
SO  - Eur Radiol. 2010 Sep;20(9):2184-93. doi: 10.1007/s00330-010-1773-z.


PMID- 20393245
OWN - NLM
STAT- MEDLINE
DCOM- 20100610
LR  - 20151221
IS  - 0972-2823 (Electronic)
IS  - 0022-3859 (Linking)
VI  - 56
IP  - 1
DP  - 2010 Jan-Mar
TI  - Cesarean delivery in preeclampsia and seasonal variation in a tropical rainforest
      belt.
PG  - 21-3
LID - 10.4103/0022-3859.62431 [doi]
AB  - BACKGROUND: The pathogenesis of preeclampsia is poorly understood and recent
      evidence suggests that the incidence varies depending upon the season. AIM: This 
      study was carried out to determine whether there is a seasonal variation in the
      presentation of preeclamptics undergoing cesarean delivery in a tropical
      rainforest belt. SETTING: A university teaching hospital. STUDY DESIGN:
      Retrospective. MATERIALS AND METHODS: The hospital records of consecutive
      patients (July 1996-June 2006) with preeclampsia, who underwent cesarean delivery
      in a tertiary care centre, were reviewed. Data collected included patient
      demographics, total number of deliveries, number of cesarean deliveries, and
      number of preeclampsia patients and time of presentation for cesarean section.
      Approval of the local ethical committee was obtained. STATISTICAL ANALYSIS: The
      EPI info software program was used for statistical analysis. RESULTS: A total of 
      6798 deliveries were recorded during the study period resulting in 6485 live
      births. There were 1579 cesarean deliveries during the period. Of these, 196
      patients had toxemia of pregnancy (166 with preeclampsia and 30 with eclampsia). 
      One hundred and forty-one patients (9% of cesarean deliveries) had cesarean
      delivery during the rainy season and 55 (3.5%) during the dry season (P < 0.05). 
      Amongst preeclampsia patients, 115 presented (7%) during the rainy season and 51 
      (3.2%) during the dry season (P < 0.05). In the eclampsia group, 26 (1.65% of
      cesarean sections) presented during the rainy season and four (0.25%) during the 
      dry season (P < 0.05). CONCLUSIONS: There was a seasonal variation in the
      cesarean delivery required for preeclampsia/eclampsia patients. This may help in 
      counseling women on when to plan their pregnancy in order to reduce the morbidity
      and mortality associated with this apparent seasonal disease.
FAU - Okafor, U V
AU  - Okafor UV
AD  - Department of Anesthesia, University of Nigeria Teaching Hospital, Ituku Ozalla, 
      Enugu, Nigeria.
FAU - Ezegwui, H U
AU  - Ezegwui HU
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Postgrad Med
JT  - Journal of postgraduate medicine
JID - 2985196R
SB  - IM
MH  - Adult
MH  - Cesarean Section/methods/*statistics & numerical data
MH  - Female
MH  - Hospitals, Teaching
MH  - Humans
MH  - Incidence
MH  - Infant, Newborn
MH  - Male
MH  - Medical Records
MH  - Meteorological Concepts
MH  - Nigeria/epidemiology
MH  - Pre-Eclampsia/*epidemiology
MH  - Pregnancy
MH  - Retrospective Studies
MH  - *Seasons
MH  - Tropical Climate
EDAT- 2010/04/16 06:00
MHDA- 2010/06/11 06:00
CRDT- 2010/04/16 06:00
PHST- 2010/04/16 06:00 [entrez]
PHST- 2010/04/16 06:00 [pubmed]
PHST- 2010/06/11 06:00 [medline]
AID - jpgm_2010_56_1_21_62431 [pii]
AID - 10.4103/0022-3859.62431 [doi]
PST - ppublish
SO  - J Postgrad Med. 2010 Jan-Mar;56(1):21-3. doi: 10.4103/0022-3859.62431.


PMID- 20392984
OWN - NLM
STAT- MEDLINE
DCOM- 20100715
LR  - 20151119
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 255
IP  - 3
DP  - 2010 Jun
TI  - Contractile reserve and extent of transmural necrosis in the setting of
      myocardial stunning: comparison at cardiac MR imaging.
PG  - 755-63
LID - 10.1148/radiol.10091191 [doi]
AB  - PURPOSE: To perform a comparison of cardiac magnetic resonance (MR)
      imaging-derived ejection fraction (EF) during low-dose dobutamine infusion
      (EF(D)) with the extent of segments with transmural necrosis in more than 50% of 
      their wall thickness (ETN) for the prediction of major adverse cardiac events
      (MACEs) and late systolic recovery soon after a first ST-segment elevation
      myocardial infarction (STEMI). MATERIALS AND METHODS: Institutional ethics
      committee approval and written informed consent were obtained. One hundred
      nineteen consecutive patients with a first STEMI, a depressed left ventricular
      EF, and an open infarct-related artery underwent MR imaging at 1 week after
      infarction. EF(D) and ETN (by using a 17-segment model) were determined, and the 
      prediction of MACEs and systolic recovery at follow-up was assessed by using area
      under the receiver operating characteristic curve (AUC) and multivariable
      regression analysis. RESULTS: During follow-up (median, 613 days; range, 312-1243
      days), 18 MACEs (five cardiac deaths, six myocardial infarctions, seven
      readmissions for heart failure) occurred. MACEs were associated with a lower
      EF(D) (43% +/- 12 [standard deviation] vs 49% +/- 10, P = .02) and a larger ETN
      (seven segments +/- three vs four segments +/- three, P < .001). Patients with
      systolic recovery (increase in EF of >5% at follow-up compared with baseline EF, 
      n = 44) displayed a higher EF(D) (51% +/- 10 vs 47% +/- 9, P = .04) and a smaller
      ETN (three segments +/- two vs five segments +/- three, P = .002) at 1 week. ETN 
      and EF(D) both related to MACEs (AUC: 0.78 vs 0.67, respectively, P = .1) and
      systolic recovery (AUC: 0.68 vs 0.62, respectively, P = .3). According to
      multivariable analysis, ETN was the only MR variable associated with time to
      MACEs (hazard ratio, 1.38; 95% confidence interval: 1.19, 1.60; P < .001) and
      systolic recovery (odds ratio, 0.76; 95% confidence interval: 0.64, 0.92; P =
      .004) independent of baseline characteristics. CONCLUSION: ETN is as useful as
      EF(D) for the prediction of MACEs and systolic recovery soon after STEMI.
CI  - Copyright RSNA, 2010
FAU - Bodi, Vicente
AU  - Bodi V
AD  - Hospital Clinico Universitario, INCLIVA, Universidad de Valencia, Blasco Ibanez
      17, 46010 Valencia, Spain. vicentbodi@hotmail.com
FAU - Husser, Oliver
AU  - Husser O
FAU - Sanchis, Juan
AU  - Sanchis J
FAU - Nunez, Julio
AU  - Nunez J
FAU - Lopez-Lereu, Maria P
AU  - Lopez-Lereu MP
FAU - Monmeneu, Jose V
AU  - Monmeneu JV
FAU - Mainar, Luis
AU  - Mainar L
FAU - Chaustre, Fabian
AU  - Chaustre F
FAU - Riegger, Gunter A J
AU  - Riegger GA
FAU - Bosch, Maria J
AU  - Bosch MJ
FAU - Chorro, Francisco J
AU  - Chorro FJ
FAU - Llacer, Angel
AU  - Llacer A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100414
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Cardiotonic Agents)
RN  - 0 (Contrast Media)
RN  - 3S12J47372 (Dobutamine)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Angioplasty
MH  - Area Under Curve
MH  - Cardiac Catheterization
MH  - Cardiotonic Agents/administration & dosage
MH  - Chi-Square Distribution
MH  - Contrast Media
MH  - Dobutamine/administration & dosage
MH  - Female
MH  - Gadolinium DTPA
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardial Contraction/physiology
MH  - Myocardial Infarction/*pathology/physiopathology/therapy
MH  - Myocardial Stunning/*pathology/physiopathology/therapy
MH  - Necrosis
MH  - Prospective Studies
MH  - Regression Analysis
MH  - Retreatment
MH  - Stents
EDAT- 2010/04/16 06:00
MHDA- 2010/07/16 06:00
CRDT- 2010/04/16 06:00
PHST- 2010/04/16 06:00 [entrez]
PHST- 2010/04/16 06:00 [pubmed]
PHST- 2010/07/16 06:00 [medline]
AID - radiol.10091191 [pii]
AID - 10.1148/radiol.10091191 [doi]
PST - ppublish
SO  - Radiology. 2010 Jun;255(3):755-63. doi: 10.1148/radiol.10091191. Epub 2010 Apr
      14.


PMID- 20392883
OWN - NLM
STAT- MEDLINE
DCOM- 20100617
LR  - 20100521
IS  - 1541-6100 (Electronic)
IS  - 0022-3166 (Linking)
VI  - 140
IP  - 6
DP  - 2010 Jun
TI  - Two food-assisted maternal and child health nutrition programs helped mitigate
      the impact of economic hardship on child stunting in Haiti.
PG  - 1139-45
LID - 10.3945/jn.109.114272 [doi]
AB  - Rigorous evaluations of food-assisted maternal and child health and nutrition
      programs are stymied by the ethics of randomizing recipients to a control
      treatment. Using nonexperimental matching methods, we evaluated the effect of 2
      such programs on child linear growth in Haiti. The 2 well-implemented programs
      offered the same services (food assistance, behavior change communication, and
      preventive health services) to pregnant and lactating women and young children.
      They differed in that one (the preventive program) used blanket targeting of all 
      children 6-23 mo, whereas the other (the recuperative program) targeted
      underweight (weight-for-age Z score < -2) children 6-59 mo, as traditionally
      done. We estimated program effects on height-for-age Z scores (HAZ) and stunting 
      (HAZ < -2) by comparing outcomes of children in program areas with matched
      children from comparable populations in the Haiti Demographic and Health Survey. 
      Children 12-41 mo in the preventive and recuperative program areas had lower
      prevalence of stunting than those in the matched control group [16 percentage
      points (pp) lower in preventive and 11 pp in recuperative]. Children in the 2
      program areas also were more likely than those in the matched control group to be
      breast-fed up to 24 mo (25 pp higher in preventive, 22 in recuperative) and
      children 12 mo and older were more likely to have received the recommended full
      schedule of vaccinations (32 pp higher in preventive, 31 in recuperative). Both
      programs improved targeted behaviors and protected child growth in a time of
      deteriorating economic circumstances.
FAU - Donegan, Shannon
AU  - Donegan S
AD  - Department of Economics, Middlebury College, Middlebury, VT 05753, USA.
FAU - Maluccio, John A
AU  - Maluccio JA
FAU - Myers, Caitlin K
AU  - Myers CK
FAU - Menon, Purnima
AU  - Menon P
FAU - Ruel, Marie T
AU  - Ruel MT
FAU - Habicht, Jean-Pierre
AU  - Habicht JP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20100414
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
SB  - IM
MH  - Adult
MH  - Anthropometry
MH  - Child Nutrition Disorders/*prevention & control
MH  - Child, Preschool
MH  - Female
MH  - *Food Services
MH  - Haiti
MH  - Humans
MH  - Infant
MH  - Male
MH  - *Maternal Health Services
MH  - Nutritional Status
MH  - *Poverty
MH  - Pregnancy
MH  - *Preventive Health Services
MH  - Young Adult
EDAT- 2010/04/16 06:00
MHDA- 2010/06/18 06:00
CRDT- 2010/04/16 06:00
PHST- 2010/04/16 06:00 [entrez]
PHST- 2010/04/16 06:00 [pubmed]
PHST- 2010/06/18 06:00 [medline]
AID - jn.109.114272 [pii]
AID - 10.3945/jn.109.114272 [doi]
PST - ppublish
SO  - J Nutr. 2010 Jun;140(6):1139-45. doi: 10.3945/jn.109.114272. Epub 2010 Apr 14.


PMID- 20392785
OWN - NLM
STAT- MEDLINE
DCOM- 20110127
LR  - 20211020
IS  - 1740-7753 (Electronic)
IS  - 1740-7745 (Linking)
VI  - 7
IP  - 5
DP  - 2010 Oct
TI  - Predictive biomarker validation in practice: lessons from real trials.
PG  - 567-73
LID - 10.1177/1740774510368574 [doi]
AB  - BACKGROUND: With the advent of targeted therapies, biomarkers provide a promising
      means of individualizing therapy through an integrated approach to prediction
      using the genetic makeup of the disease and the genotype of the patient.
      Biomarker validation has therefore become a central topic of discussion in the
      field of medicine, primarily due to the changing landscape of therapies for
      treatment of a disease and these therapies purported mechanism(s) of action.
      PURPOSE: In this report, we discuss the merits and limitations of some of the
      clinical trial designs for predictive biomarker validation using examples from
      ongoing or completed clinical trials. METHODS: The designs are broadly classified
      as retrospective (i.e., using data from previously well-conducted randomized
      controlled trials (RCT)) versus prospective (enrichment or targeted, unselected
      or all-comers, hybrid, and adaptive analysis). We discuss some of these designs
      in the context of real trials. RESULTS: Well-designed retrospective analysis of
      prospective RCT can bring forward effective treatments to marker defined subgroup
      of patients in a timely manner. An example is the KRAS gene status in colorectal 
      cancer - the benefit from cetuximab and panitumumab was demonstrated to be
      restricted to patients with wild type status based on prospectively specified
      analyses using data from previously conducted RCTs. Prospective enrichment
      designs are appropriate when compelling preliminary evidence suggests that not
      all patients will benefit from the study treatment under consideration; however, 
      this may sometimes leave questions unanswered. An example is the established
      benefit of trastuzumab as adjuvant therapy for breast cancer; a clear definition 
      of HER2-positivity and the assay reproducibility have, however, remained
      unanswered. An all-comers design is optimal where preliminary evidence regarding 
      treatment benefit and assay reproducibility is uncertain (e.g., EGFR expression
      and tyrosine kinase inhibitors in lung cancer), or to identify the most effective
      therapy from a panel of regimens (e.g., chemotherapy options in breast cancer).
      LIMITATIONS: The designs discussed here rest on the assumption that the technical
      feasibility, assay performance metrics, and the logistics of specimen collection 
      are well established and that initial results demonstrate promise with regard to 
      the predictive ability of the marker(s). CONCLUSIONS: The choice of a clinical
      trial design is driven by a combination of scientific, clinical, statistical, and
      ethical considerations. There is no one size fits all solution to predictive
      biomarker validation.
FAU - Mandrekar, Sumithra J
AU  - Mandrekar SJ
AD  - Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN
      55905, USA. mandrekar.sumithra@mayo.edu
FAU - Sargent, Daniel J
AU  - Sargent DJ
LA  - eng
GR  - CA-25224/CA/NCI NIH HHS/United States
GR  - P30 CA015083/CA/NCI NIH HHS/United States
GR  - U10 CA025224/CA/NCI NIH HHS/United States
GR  - CA-15083/CA/NCI NIH HHS/United States
GR  - N01 CA015083/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100414
PL  - England
TA  - Clin Trials
JT  - Clinical trials (London, England)
JID - 101197451
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - *Biomarkers, Tumor
MH  - Humans
MH  - Molecular Targeted Therapy
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Randomized Controlled Trials as Topic/*methods
MH  - *Research Design
MH  - Retrospective Studies
PMC - PMC3913192
MID - NIHMS548951
EDAT- 2010/04/16 06:00
MHDA- 2011/01/29 06:00
CRDT- 2010/04/16 06:00
PHST- 2010/04/16 06:00 [entrez]
PHST- 2010/04/16 06:00 [pubmed]
PHST- 2011/01/29 06:00 [medline]
AID - 1740774510368574 [pii]
AID - 10.1177/1740774510368574 [doi]
PST - ppublish
SO  - Clin Trials. 2010 Oct;7(5):567-73. doi: 10.1177/1740774510368574. Epub 2010 Apr
      14.


PMID- 20392680
OWN - NLM
STAT- MEDLINE
DCOM- 20110126
LR  - 20161125
IS  - 1878-0539 (Electronic)
IS  - 1748-6815 (Linking)
VI  - 64
IP  - 1
DP  - 2011 Jan
TI  - Body dysmorphia, self-mutilation and the reconstructive surgeon.
PG  - 4-8
LID - 10.1016/j.bjps.2010.03.029 [doi]
AB  - Body dysmorphic disorder (BDD) is a disabling preoccupation with a slight or an
      imagined defect in appearance. It is recognised in some patients who present to
      the plastic surgeon requesting multiple cosmetic procedures. Very rarely, BDD
      patients may wish for amputation of a healthy limb and may even mutilate
      themselves deliberately in order to necessitate amputation. These patients pose a
      diagnostic challenge as BDD is uncommon and they are often uncooperative whilst
      appearing mentally sound. Furthermore, they raise difficult ethical and legal
      issues for the surgeon. Although there is some guidance for the management of BDD
      patients seeking elective amputation, there is currently none for the management 
      of those who present in the emergency setting. Illustrated by the case of a man
      who, having failed to find a complicit surgeon, attempted self-amputation of the 
      hand, we review the relevant ethical, legal and management issues with advice by 
      the British Medical Association and General Medical Council.
CI  - Copyright (c) 2010 British Association of Plastic, Reconstructive and Aesthetic
      Surgeons. Published by Elsevier Ltd. All rights reserved.
FAU - Chan, James Kwok-Kwan
AU  - Chan JK
AD  - Department of Plastic and Reconstructive Surgery, Stoke Mandeville Hospital,
      Aylesbury HP21 8AL, UK. jackichan17@hotmail.com
FAU - Jones, Sophie M
AU  - Jones SM
FAU - Heywood, Anthony J
AU  - Heywood AJ
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20100413
PL  - Netherlands
TA  - J Plast Reconstr Aesthet Surg
JT  - Journal of plastic, reconstructive & aesthetic surgery : JPRAS
JID - 101264239
SB  - IM
CIN - J Plast Reconstr Aesthet Surg. 2011 Jan;64(1):8-9; discussion 9-10. PMID:
      20627759
MH  - Adult
MH  - Amputation, Traumatic/etiology/*psychology
MH  - Body Dysmorphic Disorders/complications/diagnosis/psychology/*surgery
MH  - Body Image
MH  - Emergency Service, Hospital
MH  - Hand
MH  - Humans
MH  - Male
MH  - Prognosis
MH  - Reconstructive Surgical Procedures/*methods
MH  - Risk Assessment
MH  - Self Mutilation/diagnosis/psychology/*surgery
MH  - Self-Injurious Behavior/complications/psychology
MH  - Treatment Outcome
MH  - United Kingdom
EDAT- 2010/04/16 06:00
MHDA- 2011/01/28 06:00
CRDT- 2010/04/16 06:00
PHST- 2010/01/10 00:00 [received]
PHST- 2010/03/11 00:00 [accepted]
PHST- 2010/04/16 06:00 [entrez]
PHST- 2010/04/16 06:00 [pubmed]
PHST- 2011/01/28 06:00 [medline]
AID - S1748-6815(10)00170-1 [pii]
AID - 10.1016/j.bjps.2010.03.029 [doi]
PST - ppublish
SO  - J Plast Reconstr Aesthet Surg. 2011 Jan;64(1):4-8. doi:
      10.1016/j.bjps.2010.03.029. Epub 2010 Apr 13.


PMID- 20392401
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20100415
IS  - 1022-386X (Print)
IS  - 1022-386X (Linking)
VI  - 20
IP  - 4
DP  - 2010 Apr
TI  - Association of carcinoma breast: grade and estrogen progesterone receptor
      expression.
PG  - 250-2
LID - 04.2010/JCPSP.250252 [doi]
AB  - OBJECTIVE: To determine the association between histological grade of tumour and 
      estrogen progesterone receptors (ER/PR) expression in unselected invasive
      carcinoma of breast in Malaysian patients. STUDY DESIGN: An observational study. 
      PLACE AND DURATION OF STUDY: Advanced Medical and Dental Institute and Hospital, 
      Kepala Batas, from year 2002 to 2007. METHODOLOGY: Ethical approval from Ministry
      of Health of Malaysia was obtained. Retrospective case records of patients
      presented between 2002- 2007 were reviewed for obtaining information on grade of 
      tumour and expression of ER/PR in unselected carcinoma of breast patients.
      Records with missing data were discarded. RESULTS: Out of 195 cases evaluated, 42
      cases of grade-I tumour were recorded of which 08 (19%) tested positive for ER
      and 34 (81%) tested negative, 86 cases represented grade-II tumour of which 33
      (38%) tested positive for ER and 53 (62%) were negative for ER, while out of 67
      grade-III tumours 22 (33%) were positive for ER receptors while 45 (67%) were
      negative, (chi2 statistic (df) 4.831, p=0.089). For PR, 192 cases were evaluated 
      and data was missing for 3 cases on PR status. Grade-I tumour consisted of 39
      cases of which PR +ve represented 07 (17.94%) and 32 (82.05) cases PR -ve; 86
      cases were of grade-II of which 31 (36.04%) were PR +ve and 55 (63.95%) PR -ve.
      Sixty seven cases of grade-III tumour of which 19 (28.35%) were PR +ve and 48
      (71.64) were PR -ve (chi2 statistic (df): 4.297; p=0.117). CONCLUSION: ER/PR
      positivity trend was highest for grade-II tumours compared to grade-I and
      grade-III tumours. In general ER positivity was more with grade-II and grade-III 
      tumours compared to grade I tumours. Although results did not reach statistical
      significance but there was a trend towards ER/PR positivity in grade-II and III
      tumours. So far, studies from South East Asia reported ER/PR expression more with
      low grade tumours.
FAU - Kamil, Muhammad
AU  - Kamil M
AD  - Department of Medicine, Advanced Medical and Dental Institute, Universiti Sains, 
      Malaysia. kamilpk2001@yahoo.com
FAU - Khalid, Imran
AU  - Khalid I
FAU - Hashim, Hasnah
AU  - Hashim H
FAU - Biswas, Mrinal
AU  - Biswas M
FAU - Kaur, Gurjeet
AU  - Kaur G
FAU - Islam, Rajakul
AU  - Islam R
LA  - eng
PT  - Journal Article
PL  - Pakistan
TA  - J Coll Physicians Surg Pak
JT  - Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
JID - 9606447
RN  - 0 (Receptors, Estrogen)
RN  - 0 (Receptors, Progesterone)
SB  - IM
MH  - Breast Neoplasms/epidemiology/*genetics/pathology
MH  - Female
MH  - Health Status Indicators
MH  - Humans
MH  - Malaysia/epidemiology
MH  - Neoplasm Staging
MH  - Receptors, Estrogen/*biosynthesis/genetics
MH  - Receptors, Progesterone/*biosynthesis/genetics
MH  - Retrospective Studies
EDAT- 2010/04/16 06:00
MHDA- 2011/06/03 06:00
CRDT- 2010/04/16 06:00
PHST- 2009/03/03 00:00 [received]
PHST- 2009/12/03 00:00 [accepted]
PHST- 2010/04/16 06:00 [entrez]
PHST- 2010/04/16 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
AID - 040579197 [pii]
AID - 04.2010/JCPSP.250252 [doi]
PST - ppublish
SO  - J Coll Physicians Surg Pak. 2010 Apr;20(4):250-2. doi: 04.2010/JCPSP.250252.


PMID- 20392216
OWN - NLM
STAT- MEDLINE
DCOM- 20100505
LR  - 20220309
IS  - 1749-6632 (Electronic)
IS  - 0077-8923 (Linking)
VI  - 1192
DP  - 2010 Mar
TI  - iPS cell technology in regenerative medicine.
PG  - 38-44
LID - 10.1111/j.1749-6632.2009.05213.x [doi]
AB  - The promise of treating human genetic and degenerative diseases through the
      application of pluripotent cell-based tissue engineering and regenerative
      medicine has come significantly closer to realization since the isolation of
      human embryonic stem (ES) cells. While the study of ES cells has greatly
      increased our fundamental understanding of pluripotency, technical and ethical
      limitations have been seemingly insurmountable impediments to the application of 
      these cells in the clinic. The recent discovery that somatic mammalian cells can 
      be epigenetically reprogrammed to a pluripotent state through the exogenous
      expression of the transcription factors OCT4, SOX2, KLF4, and c-MYC has yielded a
      new cell type for potential application in regenerative medicine, the induced
      pluripotent stem (iPS) cell. Here we discuss how advances in iPS cell technology 
      have led to the generation of patient-specific cell lines that can potentially be
      used to model human diseases and ultimately act as therapeutic agents.
FAU - Lengner, Christopher J
AU  - Lengner CJ
AD  - Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA.
      lengner@wi.mit.edu
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
SB  - IM
MH  - Animals
MH  - Cell Culture Techniques/history/methods
MH  - History, 21st Century
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*physiology/transplantation/virology
MH  - Kruppel-Like Factor 4
MH  - Models, Biological
MH  - Mutagenesis, Insertional/methods
MH  - Regenerative Medicine/history/*methods
RF  - 36
EDAT- 2010/04/16 06:00
MHDA- 2010/05/06 06:00
CRDT- 2010/04/16 06:00
PHST- 2010/04/16 06:00 [entrez]
PHST- 2010/04/16 06:00 [pubmed]
PHST- 2010/05/06 06:00 [medline]
AID - NYAS5213 [pii]
AID - 10.1111/j.1749-6632.2009.05213.x [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2010 Mar;1192:38-44. doi: 10.1111/j.1749-6632.2009.05213.x.


PMID- 20391848
OWN - NLM
STAT- MEDLINE
DCOM- 20100519
LR  - 20191210
IS  - 0093-0334 (Print)
IS  - 0093-0334 (Linking)
VI  - 40
IP  - 2
DP  - 2010 Mar-Apr
TI  - What are parents for? Reproductive ethics after the nonidentity problem.
PG  - 37-47
AB  - Bioethicists often use the "nonidentity problem"--the idea that a child born with
      a disability would actually be a different child if she were born without the
      disability--to defend parents' rights to have whatever children they want. After 
      all, a child is not harmed by being brought into the world with a disability;
      without the disability, she would not be brought into the world at all. But what 
      happens if we turn the moral question around and ask, not about the benefits and 
      harms to the child, but just about parental obligations? Will that lead to a
      different view of reproductive decisions?
FAU - Prusak, Bernard G
AU  - Prusak BG
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Hastings Cent Rep
JT  - The Hastings Center report
JID - 0410447
SB  - IM
MH  - Adult
MH  - *Conflict, Psychological
MH  - *Disabled Persons
MH  - Female
MH  - Genetic Engineering/*ethics
MH  - Humans
MH  - Male
MH  - *Moral Obligations
MH  - *Parents
MH  - Reproduction/*ethics
MH  - *Social Identification
MH  - Value of Life
EDAT- 2010/04/16 06:00
MHDA- 2010/05/21 06:00
CRDT- 2010/04/16 06:00
PHST- 2010/04/16 06:00 [entrez]
PHST- 2010/04/16 06:00 [pubmed]
PHST- 2010/05/21 06:00 [medline]
AID - 10.1353/hcr.0.0244 [doi]
PST - ppublish
SO  - Hastings Cent Rep. 2010 Mar-Apr;40(2):37-47. doi: 10.1353/hcr.0.0244.


PMID- 20391847
OWN - NLM
STAT- MEDLINE
DCOM- 20100519
LR  - 20191111
IS  - 0093-0334 (Print)
IS  - 0093-0334 (Linking)
VI  - 40
IP  - 2
DP  - 2010 Mar-Apr
TI  - Self-regulation, compensation, and the ethical recruitment of oocyte donors.
PG  - 25-36
AB  - Over the last couple of decades, oocyte donation has become common, important,
      and sometimes lucrative. Women who donate eggs are often offered fees, though
      ostensibly only to offset their expenses and limited to no more than $10,000,
      following recommendations adopted by the fertility industry. Is the industry
      adhering to its recommendations? A study of advertisements published in college
      newspapers raises questions.
FAU - Levine, Aaron D
AU  - Levine AD
AD  - School of Public Policy, Georgia Tech, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hastings Cent Rep
JT  - The Hastings Center report
JID - 0410447
SB  - IM
MH  - Adult
MH  - Commodification
MH  - Female
MH  - Fertilization in Vitro/*economics/*ethics
MH  - Humans
MH  - *Living Donors/ethics/legislation & jurisprudence
MH  - Marketing
MH  - Oocyte Donation/*economics/*ethics
MH  - Young Adult
EDAT- 2010/04/16 06:00
MHDA- 2010/05/21 06:00
CRDT- 2010/04/16 06:00
PHST- 2010/04/16 06:00 [entrez]
PHST- 2010/04/16 06:00 [pubmed]
PHST- 2010/05/21 06:00 [medline]
AID - 10.1353/hcr.0.0245 [doi]
PST - ppublish
SO  - Hastings Cent Rep. 2010 Mar-Apr;40(2):25-36. doi: 10.1353/hcr.0.0245.


PMID- 20391841
OWN - NLM
STAT- MEDLINE
DCOM- 20100519
LR  - 20191111
IS  - 0093-0334 (Print)
IS  - 0093-0334 (Linking)
VI  - 40
IP  - 2
DP  - 2010 Mar-Apr
TI  - Is there an ethical problem here?
PG  - 3
FAU - Robertson, John A
AU  - Robertson JA
AD  - University of Texas, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Hastings Cent Rep
JT  - The Hastings Center report
JID - 0410447
SB  - IM
MH  - Female
MH  - Humans
MH  - *Intelligence
MH  - *Living Donors
MH  - Oocyte Donation/economics/*ethics
MH  - Societies, Medical
MH  - United States
EDAT- 2010/04/16 06:00
MHDA- 2010/05/21 06:00
CRDT- 2010/04/16 06:00
PHST- 2010/04/16 06:00 [entrez]
PHST- 2010/04/16 06:00 [pubmed]
PHST- 2010/05/21 06:00 [medline]
AID - 10.1353/hcr.0.0239 [doi]
PST - ppublish
SO  - Hastings Cent Rep. 2010 Mar-Apr;40(2):3. doi: 10.1353/hcr.0.0239.


PMID- 20391688
OWN - NLM
STAT- MEDLINE
DCOM- 20100507
LR  - 20161021
IS  - 1055-3134 (Print)
IS  - 1055-3134 (Linking)
VI  - 73
IP  - 1
DP  - 2010 Spring
TI  - Promises to keep: ethical obligations at the end of life.
PG  - 4
FAU - Payne, Kate
AU  - Payne K
AD  - Saint Thomas Hospital, Nashville, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Tenn Nurse
JT  - Tennessee nurse
JID - 9102869
MH  - Humans
MH  - Moral Obligations
MH  - *Nurse's Role/psychology
MH  - *Nurse-Patient Relations/ethics
MH  - *Patient Advocacy/ethics/psychology
MH  - *Terminal Care/ethics/psychology
EDAT- 2010/04/16 06:00
MHDA- 2010/05/08 06:00
CRDT- 2010/04/16 06:00
PHST- 2010/04/16 06:00 [entrez]
PHST- 2010/04/16 06:00 [pubmed]
PHST- 2010/05/08 06:00 [medline]
PST - ppublish
SO  - Tenn Nurse. 2010 Spring;73(1):4.


PMID- 20391352
OWN - NLM
STAT- MEDLINE
DCOM- 20100614
LR  - 20100414
IS  - 1661-8157 (Print)
IS  - 1661-8157 (Linking)
VI  - 99
IP  - 8
DP  - 2010 Apr 14
TI  - [Requests for online consultations on the operative reconstruction of the
      hymen--data from the university hospital Zurich and the children's hospital
      Zurich].
PG  - 475-80
LID - 10.1024/1661-8157/a000093 [doi]
AB  - The "reconstruction of the hymen"consists in a surgical suture of the seam of a
      hymen that has been fissured due to vaginal intercourse or other causes. This
      intervention aims at triggering bleeding on the occasion of the next intercourse,
      a phenomenon often required as proof of virginity within certain traditions.
      Valid data regarding this ethically and medically controversial and predominantly
      tabooissue is scarce. In an effort to further explore this practice, we have
      collected information about hymenorrhaphy from the databases of two anonymous,
      medical, online counselling services provided by the University Hospital Zurich, 
      and explicitly for teenagers by the Children's Hospital Zurich. We found a sample
      of 22 questions from women seeking advice, and the results vividly illustrate the
      psycho-social dilemma these women face, prompting us to suggest that further
      ethical discussion, collection of empirical data and broad public education on
      issues related to sexuality are necessary.
FAU - Wild, V
AU  - Wild V
AD  - Institut fur Biomedizinische Ethik, Ethik-Zentrum, Universitat Zurich.
FAU - Neuhaus Buhler, R
AU  - Neuhaus Buhler R
FAU - Poulin, H
AU  - Poulin H
FAU - Brockes, C
AU  - Brockes C
FAU - Schmidt-Weitmann, S
AU  - Schmidt-Weitmann S
FAU - Biller-Andorno, N
AU  - Biller-Andorno N
LA  - ger
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
TT  - Anfragen an Online-Arzte uber die Moglichkeit einer operativen Rekonstruktion des
      Hymens: Datenerhebung am Universitats- und am Kinderspital Zurich.
PL  - Switzerland
TA  - Praxis (Bern 1994)
JT  - Praxis
JID - 101468093
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Coitus
MH  - Counseling
MH  - Ethics
MH  - Female
MH  - Hospitals, Pediatric
MH  - Hospitals, University
MH  - Humans
MH  - Hymen/*surgery
MH  - Online Systems
MH  - Practice Guidelines as Topic
MH  - *Reconstructive Surgical Procedures
MH  - Religion
MH  - Switzerland
MH  - Taboo
EDAT- 2010/04/15 06:00
MHDA- 2010/06/15 06:00
CRDT- 2010/04/15 06:00
PHST- 2010/04/15 06:00 [entrez]
PHST- 2010/04/15 06:00 [pubmed]
PHST- 2010/06/15 06:00 [medline]
AID - 10.1024/1661-8157/a000093 [doi]
PST - ppublish
SO  - Praxis (Bern 1994). 2010 Apr 14;99(8):475-80. doi: 10.1024/1661-8157/a000093.


PMID- 20391316
OWN - NLM
STAT- MEDLINE
DCOM- 20100804
LR  - 20100930
IS  - 1439-4413 (Electronic)
IS  - 0012-0472 (Linking)
VI  - 135
IP  - 16
DP  - 2010 Apr
TI  - [Ethical insolvency?].
PG  - 819-21
LID - 10.1055/s-0030-1251937 [doi]
AB  - The current DRG system has not only changed the economic structure of clinical
      medicine but also has profound effects on its original mission. In the present
      paper we discuss the fundamental limits of the DRG system and make a case for
      placing more emphasis on time and communication in health care.
CI  - Georg Thieme Verlag KG Stuttgart. New York.
FAU - von Weizsacker, F
AU  - von Weizsacker F
AD  - Innere Medizin I, Schlosspark-Klinik, Berlin.
      fritz.weizsaecker@schlosspark-klinik.de
FAU - Maio, G
AU  - Maio G
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Ethische Insolvenz?
DEP - 20100413
PL  - Germany
TA  - Dtsch Med Wochenschr
JT  - Deutsche medizinische Wochenschrift (1946)
JID - 0006723
SB  - IM
CIN - Dtsch Med Wochenschr. 2010 Sep;135(38):1881-2; author reply 1882. PMID: 20842612
MH  - Cost-Benefit Analysis/economics/ethics
MH  - Diagnosis-Related Groups/*economics/*ethics
MH  - Education, Medical, Continuing/economics/ethics
MH  - Education, Medical, Graduate/economics/ethics
MH  - Efficiency, Organizational/economics/ethics
MH  - *Ethics, Medical
MH  - Germany
MH  - Humans
MH  - Length of Stay/economics
MH  - National Health Programs/*economics/*ethics
MH  - Patient Readmission/economics
MH  - Physician-Patient Relations/ethics
MH  - Quality Assurance, Health Care/economics/ethics
MH  - Reimbursement Mechanisms/economics/ethics
MH  - Specialization/economics
EDAT- 2010/04/15 06:00
MHDA- 2010/08/05 06:00
CRDT- 2010/04/15 06:00
PHST- 2010/04/15 06:00 [entrez]
PHST- 2010/04/15 06:00 [pubmed]
PHST- 2010/08/05 06:00 [medline]
AID - 10.1055/s-0030-1251937 [doi]
PST - ppublish
SO  - Dtsch Med Wochenschr. 2010 Apr;135(16):819-21. doi: 10.1055/s-0030-1251937. Epub 
      2010 Apr 13.


PMID- 20391086
OWN - NLM
STAT- MEDLINE
DCOM- 20100812
LR  - 20171116
IS  - 1466-447X (Electronic)
IS  - 0264-0414 (Linking)
VI  - 28
IP  - 1
DP  - 2010 Jan
TI  - Heart rate prescribed walking training improves cardiorespiratory fitness but not
      glycaemic control in people with type 2 diabetes.
PG  - 93-9
LID - 10.1080/02640410903365685 [doi]
AB  - In this study, we examined the effects of a supervised, heart rate intensity
      prescribed walking training programme on cardiorespiratory fitness and glycaemic 
      control in people with type 2 diabetes mellitus. After receiving local ethics
      approval, 27 individuals (21 males, 6 females) with type 2 diabetes were randomly
      assigned to an experimental ("walking") or control group. Participants completed 
      a Balke-Ware test to determine peak heart rate, peak oxygen consumption
      (VO(2peak)), and peak gradient. The walking group then completed a 7-week (four
      sessions a week) supervised, heart rate prescribed walking training programme,
      whereas the control group continued daily life. After training, participants
      completed another Balke-Ware test. Fasting blood glucose and glycosylated
      haemoglobin were measured at rest. The results showed that walking training
      elicited 80% (s = 2) of peak heart rate and a rating of perceived exertion of 11 
      (s = 1). Peak heart rate and VO(2peak) were higher in the walking than in the
      control group after training (P < 0.05). Based on the peak gradient before
      training, the respiratory exchange ratio was significantly lower (P < 0.05) and
      there was a strong trend for VO(2) (P = 0.09) and heart rate (P = 0.09) to be
      lower after training at the same gradient in the walking compared with the
      control group. These improvements increased walking peak gradient by 5 min (s = 4
      min) compared with the control (P < 0.05). There was no change in fasting blood
      glucose or glycosylated haemoglobin after training. Despite no change in
      glycaemic control, heart rate prescribed walking improved peak and sub-maximal
      cardiorespiratory responses. The beneficial adaptations support the use of heart 
      rate monitoring during walking in people with type 2 diabetes mellitus.
FAU - Morton, Richard D
AU  - Morton RD
AD  - Sports and Exercise Science Research Centre, Swansea University, Singleton Park, 
      Swansea, UK. r.morton@swansea.ac.uk
FAU - West, Daniel J
AU  - West DJ
FAU - Stephens, Jeffrey W
AU  - Stephens JW
FAU - Bain, Stephen C
AU  - Bain SC
FAU - Bracken, Richard M
AU  - Bracken RM
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Sports Sci
JT  - Journal of sports sciences
JID - 8405364
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
SB  - IM
MH  - Aged
MH  - Blood Glucose/metabolism
MH  - Cardiovascular Physiological Phenomena
MH  - Diabetes Mellitus, Type 2/blood/physiopathology/*therapy
MH  - Exercise/*physiology
MH  - Exercise Test
MH  - *Exercise Therapy
MH  - Female
MH  - Glycated Hemoglobin A/metabolism
MH  - Heart Rate/*physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oxygen Consumption/*physiology
MH  - Physical Fitness/*physiology
MH  - Respiratory Physiological Phenomena
MH  - Walking/*physiology
EDAT- 2010/04/15 06:00
MHDA- 2010/08/13 06:00
CRDT- 2010/04/15 06:00
PHST- 2010/04/15 06:00 [entrez]
PHST- 2010/04/15 06:00 [pubmed]
PHST- 2010/08/13 06:00 [medline]
AID - 918540682 [pii]
AID - 10.1080/02640410903365685 [doi]
PST - ppublish
SO  - J Sports Sci. 2010 Jan;28(1):93-9. doi: 10.1080/02640410903365685.


PMID- 20390977
OWN - NLM
STAT- MEDLINE
DCOM- 20100713
LR  - 20191210
IS  - 1087-0415 (Electronic)
IS  - 1081-0730 (Linking)
VI  - 15
IP  - 1
DP  - 2010 Jan
TI  - Assessing the TARES as an ethical model for antismoking ads.
PG  - 55-75
LID - 10.1080/10810730903460542 [doi]
AB  - This study examines the ethical dimensions of public health communication, with a
      focus on antismoking public service announcements (PSAs). The content analysis of
      826 television ads from the U.S. Centers for Disease Control and Prevention's
      (CDC) Media Campaign Resource Center is an empirical testing of Baker and
      Martinson's (2001) TARES Test that directly examines persuasive messages for
      truthfulness, authenticity, respect, equity, and social responsibility. In
      general, the antismoking ads score highly on ethicality. There are significant
      relationships between ethicality and message attributes (thematic frame, emotion 
      appeal, source, and target audience). Ads that portrayed smoking as damaging to
      health and socially unacceptable score lower in ethicality than ads that focus on
      tobacco industry manipulation, addiction, dangers of secondhand smoke, and
      cessation. Emotion appeals of anger and sadness are associated with higher
      ethicality than shame and humor appeals. Ads targeting teen/youth audiences score
      lower on ethicality than ads targeting adult and general audiences. There are
      significant differences in ethicality based on source; ads produced by the CDC
      rate higher in ethicality than other sources. Theoretical implications and
      practical recommendations are discussed.
FAU - Lee, Seow Ting
AU  - Lee ST
AD  - Communications and New Media, Faculty of Arts and Social Sciences, National
      University of Singapore, Block AS6 Level 3, 11 Computing Link, Singapore 117589, 
      Singapore. seowting.lee@nus.edu.sg
FAU - Cheng, I-Huei
AU  - Cheng IH
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Health Commun
JT  - Journal of health communication
JID - 9604100
MH  - Advertising/*ethics
MH  - Centers for Disease Control and Prevention, U.S.
MH  - Health Education
MH  - Health Promotion/ethics/*methods
MH  - Humans
MH  - Persuasive Communication
MH  - Public Health
MH  - *Smoking Prevention
MH  - Social Responsibility
MH  - Television
MH  - United States
EDAT- 2010/04/15 06:00
MHDA- 2010/07/14 06:00
CRDT- 2010/04/15 06:00
PHST- 2010/04/15 06:00 [entrez]
PHST- 2010/04/15 06:00 [pubmed]
PHST- 2010/07/14 06:00 [medline]
AID - 918960863 [pii]
AID - 10.1080/10810730903460542 [doi]
PST - ppublish
SO  - J Health Commun. 2010 Jan;15(1):55-75. doi: 10.1080/10810730903460542.


PMID- 20390620
OWN - NLM
STAT- MEDLINE
DCOM- 20100709
LR  - 20170222
IS  - 1532-530X (Electronic)
IS  - 1064-0266 (Linking)
VI  - 18
IP  - 2
DP  - 2010 Mar-Apr
TI  - The therapist's appearance and recovery: perspectives on treatment, supervision, 
      and ethical implications.
PG  - 165-75
LID - 10.1080/10640260903585649 [doi]
FAU - Picot, Angela
AU  - Picot A
AD  - Insight Psychological Centers, Chicago, Illinois, USA.
FAU - McClanahan, Susan
AU  - McClanahan S
FAU - Conviser, Jenny
AU  - Conviser J
FAU - Costin, Carolyn
AU  - Costin C
FAU - Rabinor, Judith Ruskay
AU  - Rabinor JR
FAU - Hornstein, Robin
AU  - Hornstein R
FAU - Murray, Leslie Elaine
AU  - Murray LE
FAU - Levine, Martha Peaslee
AU  - Levine MP
FAU - McGilley, Beth Hartman
AU  - McGilley BH
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Eat Disord
JT  - Eating disorders
JID - 9315161
SB  - IM
MH  - Feeding and Eating Disorders/*therapy
MH  - Humans
MH  - Professional-Patient Relations/*ethics
MH  - Psychotherapy/*ethics
MH  - *Self Disclosure
EDAT- 2010/04/15 06:00
MHDA- 2010/07/10 06:00
CRDT- 2010/04/15 06:00
PHST- 2010/04/15 06:00 [entrez]
PHST- 2010/04/15 06:00 [pubmed]
PHST- 2010/07/10 06:00 [medline]
AID - 919456730 [pii]
AID - 10.1080/10640260903585649 [doi]
PST - ppublish
SO  - Eat Disord. 2010 Mar-Apr;18(2):165-75. doi: 10.1080/10640260903585649.


PMID- 20390614
OWN - NLM
STAT- MEDLINE
DCOM- 20100709
LR  - 20220318
IS  - 1532-530X (Electronic)
IS  - 1064-0266 (Linking)
VI  - 18
IP  - 2
DP  - 2010 Mar-Apr
TI  - Identifying critical competencies for psychotherapeutic practice with eating
      disordered clients: a Delphi study.
PG  - 91-109
LID - 10.1080/10640260903585524 [doi]
AB  - Mental health professionals lack systematic criteria against which to assess
      their competence to provide psychotherapy to eating disordered clients. In this
      Delphi study, a multidisciplinary panel of professionals with expertise in eating
      disorders treatment reached a consensus on essential eating disorders
      psychotherapy competencies, which included both literature-derived and
      participant-generated items. Competency domains included specialized knowledge
      and skills, professional responsibility, and therapist characteristics. An
      empirically derived, operational definition of minimum competence in
      psychotherapy for eating disorders was obtained. The essential competencies have 
      utility for practitioners, novice and experienced, who wish to assess and enhance
      their ethical practice in psychotherapy for eating disorders.
FAU - Williams, Meris
AU  - Williams M
AD  - Department of Educational and Counselling Psychology and Special Education,
      University of British Columbia, Vancouver, British Columbia, Canada.
      malw@interchange.ubc.ca
FAU - Haverkamp, Beth E
AU  - Haverkamp BE
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Eat Disord
JT  - Eating disorders
JID - 9315161
SB  - IM
MH  - *Consensus
MH  - Delphi Technique
MH  - Feeding and Eating Disorders/*therapy
MH  - Health Knowledge, Attitudes, Practice
MH  - Health Personnel
MH  - Humans
MH  - *Professional Competence
MH  - *Psychotherapy
MH  - Self-Assessment
EDAT- 2010/04/15 06:00
MHDA- 2010/07/10 06:00
CRDT- 2010/04/15 06:00
PHST- 2010/04/15 06:00 [entrez]
PHST- 2010/04/15 06:00 [pubmed]
PHST- 2010/07/10 06:00 [medline]
AID - 919453967 [pii]
AID - 10.1080/10640260903585524 [doi]
PST - ppublish
SO  - Eat Disord. 2010 Mar-Apr;18(2):91-109. doi: 10.1080/10640260903585524.


PMID- 20390489
OWN - NLM
STAT- MEDLINE
DCOM- 20100812
LR  - 20100414
IS  - 1360-0451 (Electronic)
IS  - 0954-0121 (Linking)
VI  - 22
IP  - 1
DP  - 2010 Jan
TI  - Ensuring quality of services in HIV prevention research settings: findings from a
      multi-center quality improvement pilot in East Africa.
PG  - 119-25
LID - 10.1080/09540120903012569 [doi]
AB  - Quality improvement (QI) has been widely implemented in health services but has
      not been widely applied in HIV prevention research. Most prevention research
      centers have commonly employed traditional approaches (e.g., checklists) to
      quality control that document what has been done but not the quality of what has 
      been done. Unlike other health settings, prevention research settings have unique
      characteristics and ethical requirements that require the development or
      adaptation of specific quality indicators. A QI model for health services was
      adapted for use in prevention research settings and was piloted between August
      2006 and July 2007 at three research centers in East Africa. Four hundred and
      twenty-six volunteers exit interviews were administered in two cycles.
      Quantitative and qualitative data were analyzed using Excel worksheets. QI
      meeting reports and QI plans were used to complement data from exit interviews.
      On average, 52% of total enrolled volunteers participated in the exit interview. 
      The designed QI plans successfully helped reduce volunteers' reported waiting
      time to see counselors (p<0.001) and pharmacists (p<0.001). It also increased the
      percentage of interviewed volunteers who reported being counseled on family
      planning at clinical trials (from 66 to 93%; p=0.02) at follow-up visits, and who
      were refreshed on informed consent at follow-up visits (from 90 to 96%; p=0.009).
      The percentage of interviewed volunteers that expressed satisfaction with
      services received from counselors increased (from 87 to 94%; p=0.009) while the
      percentage of volunteer satisfied with services from trial physicians remained
      constant (93%). The majority of volunteers interviewed reported satisfaction with
      other major components of research such as confidentiality, understanding of
      trial objectives, benefits and risks of participation, and risk reduction
      counseling. However, satisfaction with services from community outreach workers
      and other staff at research centers dropped over the course of the study (from
      88% in Cycle 1 to 74% in Cycle 3; p= < 0.001). Increased commitment to QI is
      crucial in ensuring quality of services and ethical conduct of HIV prevention
      research centers.
FAU - Ngongo Bahati, Prince
AU  - Ngongo Bahati P
AD  - International AIDS Vaccine Initiative, Nairobi, Kenya. pbahati@iavi.org
FAU - Kidega, William
AU  - Kidega W
FAU - Ogutu, Hilda
AU  - Ogutu H
FAU - Odada, Jane
AU  - Odada J
FAU - Bender, Bonnie
AU  - Bender B
FAU - Fast, Pat
AU  - Fast P
FAU - Becker, Julie
AU  - Becker J
FAU - Price, Matt
AU  - Price M
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - England
TA  - AIDS Care
JT  - AIDS care
JID - 8915313
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Africa, Eastern/epidemiology
MH  - Aged
MH  - Aged, 80 and over
MH  - Counseling/*standards
MH  - Female
MH  - HIV Infections/epidemiology/*prevention & control
MH  - Health Services Research/*standards
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - Program Evaluation/*standards
MH  - Quality Control
MH  - Young Adult
EDAT- 2010/04/15 06:00
MHDA- 2010/08/13 06:00
CRDT- 2010/04/15 06:00
PHST- 2010/04/15 06:00 [entrez]
PHST- 2010/04/15 06:00 [pubmed]
PHST- 2010/08/13 06:00 [medline]
AID - 917363367 [pii]
AID - 10.1080/09540120903012569 [doi]
PST - ppublish
SO  - AIDS Care. 2010 Jan;22(1):119-25. doi: 10.1080/09540120903012569.


PMID- 20390239
OWN - NLM
STAT- MEDLINE
DCOM- 20100720
LR  - 20220409
IS  - 1868-8551 (Electronic)
IS  - 1868-596X (Linking)
VI  - 27
IP  - 1
DP  - 2010
TI  - Serum-free cell culture: the serum-free media interactive online database.
PG  - 53-62
AB  - Fetal bovine serum (FBS) is a ubiquitously used essential supplement in cell
      culture media. However, there are serious scientific and ethical concerns about
      the use of FBS regarding its harvest and production. During the last three
      decades, FBS could be substituted by other supplements or by the use of defined
      chemical components in serum-free cell culture. A number of serum-free medium
      formulations have been described for mammalian and insect cell lines as well as
      for primary cultures. However, the switch to serum-free media still demands a
      time-consuming literature survey and a manufacturer search for appropriate medium
      formulations, respectively. Here we present the second collection of commercially
      available serum-free media in an updated, freely accessible interactive online
      database. Searches for serum-free media and continuous cell lines already adapted
      to serum-free culture can be performed according to various criteria. These
      include the degree of chemical definition, e.g. serum-free (SF), animal-derived
      component free (ADCF) or chemically defined (CD), and the type of medium, e.g.
      basal media, medium supplements, or full replacement media. In order to specify
      the cell lines that are adapted to serum-free media, search terms like species,
      organ, tissue, cell type and disease can be used. All commercially available
      serum-free media and adapted cell lines currently available from major
      distributors (e.g. ATCC, ECACC and DMSZ) are included in the database. Despite an
      extensive search for serum-free media and adapted cell lines, detailed
      information from certain companies and suppliers is still lacking and is
      specifically highlighted. It is intended to create a platform for the interactive
      exchange of information and experience by experts in the field in order to
      continuously improve and extend the serum-free online database. The database is
      accessible at http://www.goodcellculture.com/
FAU - Brunner, Daniel
AU  - Brunner D
AD  - zet - Centre for Alternative and Complementary Methods to Animal Testing, Linz,
      Austria.
FAU - Frank, Jurgen
AU  - Frank J
FAU - Appl, Helmut
AU  - Appl H
FAU - Schoffl, Harald
AU  - Schoffl H
FAU - Pfaller, Walter
AU  - Pfaller W
FAU - Gstraunthaler, Gerhard
AU  - Gstraunthaler G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - ALTEX
JT  - ALTEX
JID - 100953980
RN  - 0 (Culture Media, Serum-Free)
SB  - IM
MH  - Animal Testing Alternatives
MH  - Animal Welfare
MH  - Cell Culture Techniques/ethics/*methods
MH  - *Culture Media, Serum-Free
MH  - *Databases, Factual
MH  - *Internet
EDAT- 2010/04/15 06:00
MHDA- 2010/07/21 06:00
CRDT- 2010/04/15 06:00
PHST- 2010/04/15 06:00 [entrez]
PHST- 2010/04/15 06:00 [pubmed]
PHST- 2010/07/21 06:00 [medline]
AID - 10.14573/altex.2010.1.53 [doi]
PST - ppublish
SO  - ALTEX. 2010;27(1):53-62. doi: 10.14573/altex.2010.1.53.


PMID- 20390237
OWN - NLM
STAT- MEDLINE
DCOM- 20100720
LR  - 20151119
IS  - 1868-8551 (Electronic)
IS  - 1868-596X (Linking)
VI  - 27
IP  - 1
DP  - 2010
TI  - Markers of murine embryonic and neural stem cells, neurons and astrocytes:
      reference points for developmental neurotoxicity testing.
PG  - 17-42
AB  - Developmental neurotoxicity (DNT) is a serious concern for environmental
      chemicals, as well as for food and drug constituents. Animal-based DNT models
      have relatively low sensitivity, and they are burdened by high work-load, cost
      and animal ethics. Murine embryonic stem cells (mESC) recapitulate several
      critical processes involved in the development of the nervous system if they are 
      induced to differentiate into neural cells. They therefore represent an
      alternative toxicological model to predict human hazard. In this review, we
      discuss how mESC can be used for DNT assays. We have compiled a list of mRNA
      markers that define undifferentiated mESC (n = 42), neural stem cells (n = 73),
      astrocytes (n = 25) and the pattern of different neuronal and non-neuronal cell
      types generated (n = 57). We propose that transcriptional profiling can be used
      as a sensitive endpoint in toxicity assays to distinguish neural differentiation 
      states during normal and disturbed development. Importantly, we believe that it
      can be scaled up to relatively high throughput whilst still providing rich
      information on disturbances affecting small cell subpopulations. Moreover, this
      approach can provide insight into underlying mechanisms and pathways of toxicity.
      We broadly discuss the methodological basis of marker lists and DNT assay design.
      The discussion is put in the context of a new generation of alternative assays
      (embryonic stem cell based DNT testing = ESDNT V2.0), that may later include
      human induced pluripotent stem cells, and that are not designed for 1:1
      replacement of animal experiments, but are rather intended to improve human risk 
      assessment by using independent scientific principles.
FAU - Kuegler, Philipp B
AU  - Kuegler PB
AD  - University of Konstanz, Germany.
FAU - Zimmer, Bastian
AU  - Zimmer B
FAU - Waldmann, Tanja
AU  - Waldmann T
FAU - Baudis, Birte
AU  - Baudis B
FAU - Ilmjarv, Sten
AU  - Ilmjarv S
FAU - Hescheler, Jurgen
AU  - Hescheler J
FAU - Gaughwin, Phil
AU  - Gaughwin P
FAU - Brundin, Patrik
AU  - Brundin P
FAU - Mundy, William
AU  - Mundy W
FAU - Bal-Price, Anna K
AU  - Bal-Price AK
FAU - Schrattenholz, Andre
AU  - Schrattenholz A
FAU - Krause, Karl-Heinz
AU  - Krause KH
FAU - van Thriel, Christoph
AU  - van Thriel C
FAU - Rao, Mahendra S
AU  - Rao MS
FAU - Kadereit, Suzanne
AU  - Kadereit S
FAU - Leist, Marcel
AU  - Leist M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Germany
TA  - ALTEX
JT  - ALTEX
JID - 100953980
RN  - 0 (Biomarkers)
SB  - IM
MH  - Animals
MH  - Astrocytes/*cytology/metabolism
MH  - Biomarkers/*metabolism
MH  - Embryonic Stem Cells/*metabolism
MH  - Mice
MH  - Neurons/*cytology
MH  - Stem Cells/*metabolism
MH  - Toxicity Tests/*methods/standards
RF  - 245
EDAT- 2010/04/15 06:00
MHDA- 2010/07/21 06:00
CRDT- 2010/04/15 06:00
PHST- 2010/04/15 06:00 [entrez]
PHST- 2010/04/15 06:00 [pubmed]
PHST- 2010/07/21 06:00 [medline]
PST - ppublish
SO  - ALTEX. 2010;27(1):17-42.


PMID- 20389316
OWN - NLM
STAT- MEDLINE
DCOM- 20100504
LR  - 20161125
IS  - 1175-8716 (Electronic)
IS  - 0028-8446 (Linking)
VI  - 123
IP  - 1312
DP  - 2010 Apr 9
TI  - Chiropractic claims in the English-speaking world.
PG  - 36-44
AB  - BACKGROUND: Some chiropractors and their associations claim that chiropractic is 
      effective for conditions that lack sound supporting evidence or scientific
      rationale. This study therefore sought to determine the frequency of World Wide
      Web claims of chiropractors and their associations to treat, asthma,
      headache/migraine, infant colic, colic, ear infection/earache/otitis media, neck 
      pain, whiplash (not supported by sound evidence), and lower back pain (supported 
      by some evidence). METHODS: A review of 200 chiropractor websites and 9
      chiropractic associations' World Wide Web claims in Australia, Canada, New
      Zealand, the United Kingdom, and the United States was conducted between 1
      October 2008 and 26 November 2008. The outcome measure was claims (either direct 
      or indirect) regarding the eight reviewed conditions, made in the context of
      chiropractic treatment. RESULTS: We found evidence that 190 (95%) chiropractor
      websites made unsubstantiated claims regarding at least one of the conditions.
      When colic and infant colic data were collapsed into one heading, there was
      evidence that 76 (38%) chiropractor websites made unsubstantiated claims about
      all the conditions not supported by sound evidence. Fifty-six (28%) websites and 
      4 of the 9 (44%) associations made claims about lower back pain, whereas 179
      (90%) websites and all 9 associations made unsubstantiated claims about
      headache/migraine. Unsubstantiated claims were made about asthma, ear
      infection/earache/otitis media, neck pain, CONCLUSIONS: The majority of
      chiropractors and their associations in the English-speaking world seem to make
      therapeutic claims that are not supported by sound evidence, whilst only 28% of
      chiropractor websites promote lower back pain, which is supported by some
      evidence. We suggest the ubiquity of the unsubstantiated claims constitutes an
      ethical and public health issue.
FAU - Ernst, Edzard
AU  - Ernst E
AD  - Complementary Medicine, Peninsula Medical School, University of Exeter, Exeter,
      England.
FAU - Gilbey, Andrew
AU  - Gilbey A
LA  - eng
PT  - Journal Article
DEP - 20100409
PL  - New Zealand
TA  - N Z Med J
JT  - The New Zealand medical journal
JID - 0401067
SB  - IM
MH  - Asthma/therapy
MH  - Australia
MH  - Back Pain/therapy
MH  - Canada
MH  - *Chiropractic
MH  - Colic/therapy
MH  - *Deception
MH  - Ethics, Medical
MH  - Evidence-Based Medicine
MH  - Headache/therapy
MH  - Humans
MH  - Infant
MH  - *Internet
MH  - *Marketing of Health Services
MH  - Migraine Disorders/therapy
MH  - Neck Pain/therapy
MH  - New Zealand
MH  - Otitis Media/therapy
MH  - United Kingdom
MH  - United States
MH  - Whiplash Injuries/therapy
EDAT- 2010/04/15 06:00
MHDA- 2010/05/05 06:00
CRDT- 2010/04/15 06:00
PHST- 2010/04/15 06:00 [entrez]
PHST- 2010/04/15 06:00 [pubmed]
PHST- 2010/05/05 06:00 [medline]
PST - epublish
SO  - N Z Med J. 2010 Apr 9;123(1312):36-44.


PMID- 20389041
OWN - NLM
STAT- MEDLINE
DCOM- 20110621
LR  - 20110304
IS  - 1662-8063 (Electronic)
IS  - 1662-4246 (Linking)
VI  - 14
IP  - 2
DP  - 2011
TI  - The storage and use of biological tissue samples from minors for research: a
      focus group study.
PG  - 68-76
LID - 10.1159/000294185 [doi]
AB  - Genetic research on pediatric stored tissue samples raises specific ethical
      questions that differ from those raised when adults are the donors. To
      investigate opinions on this matter, we conducted 10 focus group discussions.
      Five focus groups were conducted with adult participants and 5 had teenage
      participants between 15 and 19 years old. The discussions were analyzed with
      NVIVO 8 (qualitative research software). We found the following recurrent
      categories: the requirement that research should not pose any burden on children 
      and that it should benefit other children, the trust people had in the role of
      parents, the need for information and the growth towards autonomy. Both the
      adults and teenagers we interviewed thought that the inclusion of tissue samples 
      from minors in research had ethical implications. A major concern was that
      nontherapeutic research would pose no extra burden on children, which would
      assume the use of nonintrusive methods of gathering samples and the use of
      samples that were gathered in a diagnostic context. Participants, however, also
      understood the necessity of such research. The overall impression was that
      parents would be the best persons to make decisions on behalf of a small child
      and that the same parents would engage their children in the decision-making when
      they grew older. People thought that there was a duty to recontact minors when
      they reached the age of competence but on a best-effort basis.
CI  - Copyright (c) 2010 S. Karger AG, Basel.
FAU - Hens, K
AU  - Hens K
AD  - Centre for Biomedical Ethics and Law, Katholieke Universiteit Leuven, Leuven,
      Belgium. Kristien.Hens@med.kuleuven.be
FAU - Nys, H
AU  - Nys H
FAU - Cassiman, J-J
AU  - Cassiman JJ
FAU - Dierickx, K
AU  - Dierickx K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100409
PL  - Switzerland
TA  - Public Health Genomics
JT  - Public health genomics
JID - 101474167
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Belgium
MH  - Decision Making
MH  - *Ethics, Research
MH  - Female
MH  - *Focus Groups
MH  - Genetic Research/*ethics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Minors
MH  - Parental Consent
MH  - Specimen Handling
MH  - Tissue Banks/*ethics
EDAT- 2010/04/15 06:00
MHDA- 2011/06/22 06:00
CRDT- 2010/04/15 06:00
PHST- 2009/06/04 00:00 [received]
PHST- 2009/10/22 00:00 [accepted]
PHST- 2010/04/15 06:00 [entrez]
PHST- 2010/04/15 06:00 [pubmed]
PHST- 2011/06/22 06:00 [medline]
AID - 000294185 [pii]
AID - 10.1159/000294185 [doi]
PST - ppublish
SO  - Public Health Genomics. 2011;14(2):68-76. doi: 10.1159/000294185. Epub 2010 Apr
      9.


PMID- 20388311
OWN - NLM
STAT- MEDLINE
DCOM- 20101008
LR  - 20101118
IS  - 1488-2159 (Electronic)
IS  - 0709-8936 (Linking)
VI  - 76
DP  - 2010
TI  - Quantifying light energy delivered to a Class I restoration.
PG  - a23
AB  - PURPOSE: To measure the amount of light energy that dental students actually
      deliver to a Class I preparation in a dental mannequin. MATERIALS AND METHODS:
      Approval for the study was obtained from the Dalhousie University Health Sciences
      Research Ethics Board. Each of 20 third-year dental students light-cured a Class 
      I preparation in tooth 27 in a mannequin head. A photodetector located at the
      bottom of the cavity preparation measured how much light would be received by a
      restoration. Each student cured the simulated restoration for 20 seconds using a 
      quartz-tungsten-halogen curing light (Optilux 401). The irradiance received
      (mW/cm2) was recorded in real time, and the energy per unit area (J/cm2)
      delivered to the detector by each student was calculated. The students were then 
      given detailed instructions on how to effectively use the curing light, and the
      experiment was repeated. RESULTS: When the curing light was fixed directly over
      the tooth, the greatest amount of light energy delivered to the detector in 20
      seconds was 13.9 +/- 0.4 J/cm2. Before instruction, the students delivered
      between 2.0 and 12.0 J/cm2 (mean +/- standard deviation [SD]: 7.9 +/- 2.7 J/cm2).
      After receiving detailed instructions, the same students delivered between 7.7
      and 13.4 J/cm2 (mean +/- SD: 10.0 +/- 1.4 J/cm2). A paired student"s t test
      showed that instruction resulted in a significant improvement (p < 0.001).
      CONCLUSIONS: Although instruction yielded improvements, the mean energy delivered
      was much less (7.9 J/cm2 before instruction and 10.0 J/cm2 after instruction)
      than the expected 13.9 J/cm2. To maximize the energy delivered, the operator
      should wear eye protection, should watch what he or she is doing and should hold 
      the light both close to and perpendicular to the restoration.
FAU - Price, Richard B T
AU  - Price RB
AD  - Department of Dental Clinical Sciences, Dalhousie University, Halifax, Nova
      Scotia. rbprice@dal.ca
FAU - McLeod, Melanie E
AU  - McLeod ME
FAU - Felix, Christopher M
AU  - Felix CM
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Canada
TA  - J Can Dent Assoc
JT  - Journal (Canadian Dental Association)
JID - 7907605
RN  - 0 (Composite Resins)
SB  - IM
MH  - Analysis of Variance
MH  - Composite Resins/radiation effects
MH  - *Curing Lights, Dental
MH  - Dental Restoration, Permanent/classification/*methods
MH  - Dentistry, Operative/education
MH  - Eye Protective Devices
MH  - Hardness Tests
MH  - Humans
MH  - Light-Curing of Dental Adhesives/*methods
MH  - Manikins
MH  - Photometry
MH  - Students, Dental
EDAT- 2010/04/15 06:00
MHDA- 2010/10/12 06:00
CRDT- 2010/04/15 06:00
PHST- 2010/04/15 06:00 [entrez]
PHST- 2010/04/15 06:00 [pubmed]
PHST- 2010/10/12 06:00 [medline]
PST - ppublish
SO  - J Can Dent Assoc. 2010;76:a23.


PMID- 20388211
OWN - NLM
STAT- MEDLINE
DCOM- 20100726
LR  - 20220330
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 11
DP  - 2010 Apr 13
TI  - Reporting bias in medical research - a narrative review.
PG  - 37
LID - 10.1186/1745-6215-11-37 [doi]
AB  - Reporting bias represents a major problem in the assessment of health care
      interventions. Several prominent cases have been described in the literature, for
      example, in the reporting of trials of antidepressants, Class I anti-arrhythmic
      drugs, and selective COX-2 inhibitors. The aim of this narrative review is to
      gain an overview of reporting bias in the medical literature, focussing on
      publication bias and selective outcome reporting. We explore whether these types 
      of bias have been shown in areas beyond the well-known cases noted above, in
      order to gain an impression of how widespread the problem is. For this purpose,
      we screened relevant articles on reporting bias that had previously been obtained
      by the German Institute for Quality and Efficiency in Health Care in the context 
      of its health technology assessment reports and other research work, together
      with the reference lists of these articles.We identified reporting bias in 40
      indications comprising around 50 different pharmacological, surgical (e.g.
      vacuum-assisted closure therapy), diagnostic (e.g. ultrasound), and preventive
      (e.g. cancer vaccines) interventions. Regarding pharmacological interventions,
      cases of reporting bias were, for example, identified in the treatment of the
      following conditions: depression, bipolar disorder, schizophrenia, anxiety
      disorder, attention-deficit hyperactivity disorder, Alzheimer's disease, pain,
      migraine, cardiovascular disease, gastric ulcers, irritable bowel syndrome,
      urinary incontinence, atopic dermatitis, diabetes mellitus type 2,
      hypercholesterolaemia, thyroid disorders, menopausal symptoms, various types of
      cancer (e.g. ovarian cancer and melanoma), various types of infections (e.g. HIV,
      influenza and Hepatitis B), and acute trauma. Many cases involved the withholding
      of study data by manufacturers and regulatory agencies or the active attempt by
      manufacturers to suppress publication. The ascertained effects of reporting bias 
      included the overestimation of efficacy and the underestimation of safety risks
      of interventions.In conclusion, reporting bias is a widespread phenomenon in the 
      medical literature. Mandatory prospective registration of trials and public
      access to study data via results databases need to be introduced on a worldwide
      scale. This will allow for an independent review of research data, help fulfil
      ethical obligations towards patients, and ensure a basis for fully-informed
      decision making in the health care system.
FAU - McGauran, Natalie
AU  - McGauran N
AD  - Institute for Quality and Efficiency in Health Care, Dillenburger Str 27, 51105
      Cologne, Germany. n.mcgauran@iqwig.de
FAU - Wieseler, Beate
AU  - Wieseler B
FAU - Kreis, Julia
AU  - Kreis J
FAU - Schuler, Yvonne-Beatrice
AU  - Schuler YB
FAU - Kolsch, Heike
AU  - Kolsch H
FAU - Kaiser, Thomas
AU  - Kaiser T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100413
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
SB  - IM
MH  - Access to Information
MH  - Animals
MH  - *Biomedical Research
MH  - Consumer Product Safety
MH  - Databases as Topic
MH  - *Evidence-Based Medicine
MH  - Humans
MH  - *Periodicals as Topic
MH  - *Publication Bias
MH  - Registries
MH  - Reproducibility of Results
MH  - Treatment Outcome
MH  - Truth Disclosure
RF  - 254
PMC - PMC2867979
EDAT- 2010/04/15 06:00
MHDA- 2010/07/27 06:00
CRDT- 2010/04/15 06:00
PHST- 2009/11/07 00:00 [received]
PHST- 2010/04/13 00:00 [accepted]
PHST- 2010/04/15 06:00 [entrez]
PHST- 2010/04/15 06:00 [pubmed]
PHST- 2010/07/27 06:00 [medline]
AID - 1745-6215-11-37 [pii]
AID - 10.1186/1745-6215-11-37 [doi]
PST - epublish
SO  - Trials. 2010 Apr 13;11:37. doi: 10.1186/1745-6215-11-37.


PMID- 20388119
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20151119
IS  - 1095-8355 (Electronic)
IS  - 1065-6995 (Linking)
VI  - 34
IP  - 9
DP  - 2010 Sep
TI  - In vitro differentiation of human amniotic fluid-derived cells: augmentation
      towards a neuronal dopaminergic phenotype.
PG  - 959-67
LID - 10.1042/CBI20090445 [doi]
AB  - Amniotic fluid is known to yield a number of cell types which are multipotent,
      ethically derived, genetically stable, easily grown, expanded and possess
      favourable immunogenicity, which has resulted in an increasing interest for use
      in various neuronal disorders such as Parkinson's disease. The neuronal potential
      of cells derived from the adherent fraction of amniotic fluid, routinely taken by
      amniocentesis, are least explored. The aim of the present study was to
      investigate the capacity of these cells for neuronal and dopaminergic
      differentiation using in vitro differentiation protocols with canonical inductive
      factors not previously tested. To do this, samples derived from multiple donors
      were grown under four conditions: standard serum-containing media, NB
      (neurobasal) media designed specifically for propagation and maintenance of
      neuronal cells, NB media with addition of retinoic acid and BDNF (brain-derived
      neurotrophic factor) for NI (neuronal induction), and NB media with addition of
      FGF8 (fibroblast growth factor-8) and Shh (sonic hedgehog) after NI. Our results 
      showed the presence of multiple neuronal markers after growth in serum-containing
      medium [TUJ1, MAP2, NF-M, TH (tyrosine hydroxylase)], which was significantly
      up-regulated after serum withdrawal in NB medium alone with induction of NeuN
      (neuronal nuclei) and NSE (neuron-specific enolase). NI and DA.I (dopaminergic
      induction) was accompanied by further increases in expression and a distinct
      transition to a sustained neuronal morphology. Western blot analysis confirmed
      increasing TH expression and NURR1, expressed in base serum-containing media,
      found to be down-regulated after induction. In conclusion, these cells possess a 
      highly favourable base neuronal and dopaminergic prepotential, which may easily
      be accentuated by standard induction protocols.
FAU - Pfeiffer, Shona
AU  - Pfeiffer S
AD  - University College Dublin, School of Biomolecular and Biomedical Research,
      Laboratory of Developmental Neurobiology, Conway Institute, Belfield, Dublin 4,
      Ireland.
FAU - McLaughlin, David
AU  - McLaughlin D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Cell Biol Int
JT  - Cell biology international
JID - 9307129
RN  - 0 (Biomarkers)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Amniotic Fluid/*cytology
MH  - Biomarkers/metabolism
MH  - *Cell Differentiation/drug effects
MH  - Cell Proliferation/drug effects
MH  - Cell Shape/drug effects
MH  - Dopamine/*metabolism/pharmacology
MH  - Humans
MH  - Neurons/*cytology/*metabolism
MH  - Phenotype
EDAT- 2010/04/15 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/04/15 06:00
PHST- 2010/04/15 06:00 [entrez]
PHST- 2010/04/15 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - CBI20090445 [pii]
AID - 10.1042/CBI20090445 [doi]
PST - ppublish
SO  - Cell Biol Int. 2010 Sep;34(9):959-67. doi: 10.1042/CBI20090445.


PMID- 20387758
OWN - NLM
STAT- MEDLINE
DCOM- 20100423
LR  - 20100414
IS  - 0023-7205 (Print)
IS  - 0023-7205 (Linking)
VI  - 107
IP  - 9
DP  - 2010 Mar 3-9
TI  - [The medical profession and sick listing. The ethics in sick listing situations
      challenged by insidious lawlessness].
PG  - 592-5
FAU - Rudebeck, Carl Edvard
AU  - Rudebeck CE
AD  - Halsocentralen Esplanaden, Vastervik. carl.edvard.rudebeck@ltkalmar.se
LA  - swe
PT  - Journal Article
TT  - Lakarkaren och sjukskrivningarna. Etiken i sjukskrivningssituationen utmanas av
      en smygande lagloshet.
PL  - Sweden
TA  - Lakartidningen
JT  - Lakartidningen
JID - 0027707
SB  - IM
MH  - *Ethics, Medical
MH  - Humans
MH  - Insurance, Health/ethics/legislation & jurisprudence
MH  - *Physician's Role
MH  - *Sick Leave/legislation & jurisprudence
MH  - Sweden
MH  - Work Capacity Evaluation
EDAT- 2010/04/15 06:00
MHDA- 2010/04/24 06:00
CRDT- 2010/04/15 06:00
PHST- 2010/04/15 06:00 [entrez]
PHST- 2010/04/15 06:00 [pubmed]
PHST- 2010/04/24 06:00 [medline]
PST - ppublish
SO  - Lakartidningen. 2010 Mar 3-9;107(9):592-5.


PMID- 20386481
OWN - NLM
STAT- MEDLINE
DCOM- 20100804
LR  - 20220408
IS  - 1533-4287 (Electronic)
IS  - 1064-8011 (Linking)
VI  - 24
IP  - 5
DP  - 2010 May
TI  - A time motion analysis of bouldering style competitive rock climbing.
PG  - 1356-60
LID - 10.1519/JSC.0b013e3181cf75bd [doi]
AB  - Limited research has been performed on competitive bouldering. The aim of this
      study was to quantify the movement dynamics of elite boulder climbers. Six
      climbers were filmed during a national competition consisting of 5 novel climbing
      problems or routes. Two problems were randomly selected and film footage was
      analyzed using Kandle Swinger Pro software to determine type and duration
      (seconds) of bouldering movements. All subjects provided consent, and the study
      had ethical approval. The mean +/- SD were determined for number of attempts per 
      problem, duration of attempt, time on hold, and time to reach between holds.
      Exercise:recovery ratios were also calculated. On average, climbers attempted a
      problem 3.0 +/- 0.5 times, with an attempt lasting 28.9 +/- 10.8 seconds and rest
      periods of 114 +/- 31 seconds between attempts. Average time gripping holds was
      7.9 +/- 1.3 seconds, with approximately 0.5 +/- 0.1 seconds recovery between
      reaching for holds. The exercise-to-recovery ratio was approximately 1:4 for
      attempting a problem and approximately 13:1 for forearm muscles during climbing. 
      The exercise-to-recovery ratios allow sufficient time for recovery during and
      after a problem. However, the prolonged contraction of forearm muscles indicates 
      the importance of strength and endurance in these muscles. Video analysis was
      found to be a useful tool for the quantification of movement characteristics of
      competitive elite boulders. Data collected could be utilized in the design of
      sport-specific tests and training programs. Future research could examine a
      larger number of athletes and problems and help develop performance tests and
      training interventions for bouldering.
FAU - White, Dominic J
AU  - White DJ
AD  - Sport and Exercise Group, University of Teesside, Middlesbrough, England.
      D.J.White@tees.ac.uk
FAU - Olsen, Peter D
AU  - Olsen PD
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Strength Cond Res
JT  - Journal of strength and conditioning research
JID - 9415084
SB  - IM
MH  - Adult
MH  - Athletic Performance/*physiology
MH  - Humans
MH  - Mountaineering/*physiology
MH  - Physical Fitness/physiology
MH  - Reproducibility of Results
MH  - *Time and Motion Studies
MH  - *Videotape Recording
EDAT- 2010/04/14 06:00
MHDA- 2010/08/05 06:00
CRDT- 2010/04/14 06:00
PHST- 2010/04/14 06:00 [entrez]
PHST- 2010/04/14 06:00 [pubmed]
PHST- 2010/08/05 06:00 [medline]
AID - 10.1519/JSC.0b013e3181cf75bd [doi]
PST - ppublish
SO  - J Strength Cond Res. 2010 May;24(5):1356-60. doi: 10.1519/JSC.0b013e3181cf75bd.


PMID- 20385291
OWN - NLM
STAT- MEDLINE
DCOM- 20100714
LR  - 20220409
IS  - 1531-5037 (Electronic)
IS  - 0022-3468 (Linking)
VI  - 45
IP  - 4
DP  - 2010 Apr
TI  - Evaluation of relevance of the components of Pediatric Surgery residency training
      in West Africa.
PG  - 801-5
LID - 10.1016/j.jpedsurg.2009.10.051 [doi]
AB  - PURPOSE: The aim of the study was to determine if pediatric surgery residency
      training program in West Africa addresses the realities of posttraining practice.
      METHODS: The study used a cross-sectional survey of 36 pediatric surgeons trained
      in West Africa using self-administered questionnaires. RESULTS: Overall, 26 (72%)
      responded. Although 21 (81%) had adequate exposures in most surgical components
      of training, 18 (69%) were exposed to most of the nonsurgical components. The
      least in exposure and use were prenatal management, microvascular and
      laparoscopic surgeries, hospital administration, and finance management.
      Pediatric urology, gastroenterology, oncology, trauma, neonatal surgery, burn
      management, and hepatobiliary surgery were rated as useful and relevant to
      practice by 22 (85%) of the respondents. Many nonsurgical areas that receive less
      emphasis in training were regarded as useful in practice by all respondents
      including ethical decision making, accessing scientific literature, communication
      skills with colleagues and patient's guardian, and medical research. Significant 
      challenges to training were lack of tertiary children's hospital, dearth of
      facilities, and inadequate mentoring. CONCLUSION: The components of pediatric
      surgery training program in West Africa are relevant to the practice of the
      specialty in our setting. Areas that may enhance training outcome include
      improving exposure to all components through multi-institutional and
      international collaboration and improving existing facilities.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Ekenze, Sebastian O
AU  - Ekenze SO
AD  - Subdepartment of Pediatric Surgery, University of Nigeria Teaching Hospital,
      Enugu, Nigeria. sebekenze@gmail.com
FAU - Ameh, Emmanuel A
AU  - Ameh EA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pediatr Surg
JT  - Journal of pediatric surgery
JID - 0052631
SB  - IM
MH  - Africa, Western
MH  - *Competency-Based Education
MH  - Cross-Sectional Studies
MH  - Health Care Surveys
MH  - Humans
MH  - *Internship and Residency
MH  - Pediatrics/*education
MH  - Program Evaluation
MH  - Specialties, Surgical/*education
EDAT- 2010/04/14 06:00
MHDA- 2010/07/16 06:00
CRDT- 2010/04/14 06:00
PHST- 2009/07/11 00:00 [received]
PHST- 2009/10/18 00:00 [revised]
PHST- 2009/10/20 00:00 [accepted]
PHST- 2010/04/14 06:00 [entrez]
PHST- 2010/04/14 06:00 [pubmed]
PHST- 2010/07/16 06:00 [medline]
AID - S0022-3468(09)00849-5 [pii]
AID - 10.1016/j.jpedsurg.2009.10.051 [doi]
PST - ppublish
SO  - J Pediatr Surg. 2010 Apr;45(4):801-5. doi: 10.1016/j.jpedsurg.2009.10.051.


PMID- 20384072
OWN - NLM
STAT- MEDLINE
DCOM- 20100420
LR  - 20100413
IS  - 0023-7205 (Print)
IS  - 0023-7205 (Linking)
VI  - 107
IP  - 7
DP  - 2010 Feb 17-23
TI  - [Today's medical ethics challenge].
PG  - 412-3
FAU - Andren-Sandberg, Ake
AU  - Andren-Sandberg A
AD  - Gastrocentrum kirurgi, Karolinska universitetssjukhuset, Huddinge.
      ake.andren-sandberg@karolinska.se
FAU - Permert, Johan
AU  - Permert J
LA  - swe
PT  - Journal Article
TT  - Dagens medicinska etikutmaning.
PL  - Sweden
TA  - Lakartidningen
JT  - Lakartidningen
JID - 0027707
SB  - IM
CIN - Lakartidningen. 2010 Mar 10-16;107(10):698. PMID: 20405571
MH  - Delivery of Health Care/*ethics
MH  - *Ethics, Medical
MH  - Health Services Misuse
MH  - Humans
MH  - Resource Allocation/ethics
MH  - Sweden
EDAT- 2010/04/14 06:00
MHDA- 2010/04/21 06:00
CRDT- 2010/04/14 06:00
PHST- 2010/04/14 06:00 [entrez]
PHST- 2010/04/14 06:00 [pubmed]
PHST- 2010/04/21 06:00 [medline]
PST - ppublish
SO  - Lakartidningen. 2010 Feb 17-23;107(7):412-3.


PMID- 20384046
OWN - NLM
STAT- MEDLINE
DCOM- 20100430
LR  - 20100413
IS  - 0035-3639 (Print)
IS  - 0035-3639 (Linking)
VI  - 31
IP  - 1
DP  - 2010 Jan-Feb
TI  - [A reflection on love, medicine and euthanasia: I know what I like and I like
      what I know, but is that true?].
PG  - 5-13
AB  - This paper presents the medical practice according to the occidental philosophy
      (Platon, Spinoza, Kant). Relationships with the concept of "love" (eros, philia, 
      agape) will be described, and the concept of dignity and autonomy as well. The
      reflection will focus on the end of life aspects. Although medicine cannot avoid 
      morality, ethic, and deontology, it is also part of philosophy and must warrant
      the respect of human dignity, especially when a physician helps a patient to die.
FAU - Lossignol, D
AU  - Lossignol D
AD  - Unite des Soins Supportifs et Palliatifs, Institut Jules Bordet, Bruxelles.
      dominique.lossignol@bordet.be
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Une reflexion sur l'amour, la medecine et l'euthanasie: je connais ce que j'aime 
      et j'aime ce que je connais, mais est-ce bien vrai?
PL  - Belgium
TA  - Rev Med Brux
JT  - Revue medicale de Bruxelles
JID - 8003474
SB  - IM
MH  - Attitude to Death
MH  - *Ethics, Medical
MH  - Euthanasia/ethics
MH  - Humans
MH  - *Love
MH  - *Philosophy, Medical
MH  - Physician-Patient Relations
MH  - Religion
MH  - *Right to Die
MH  - Suicide, Assisted/ethics
EDAT- 2010/04/14 06:00
MHDA- 2010/05/01 06:00
CRDT- 2010/04/14 06:00
PHST- 2010/04/14 06:00 [entrez]
PHST- 2010/04/14 06:00 [pubmed]
PHST- 2010/05/01 06:00 [medline]
PST - ppublish
SO  - Rev Med Brux. 2010 Jan-Feb;31(1):5-13.


PMID- 20383588
OWN - NLM
STAT- MEDLINE
DCOM- 20101220
LR  - 20211020
IS  - 1572-8633 (Electronic)
IS  - 1386-7423 (Linking)
VI  - 13
IP  - 3
DP  - 2010 Aug
TI  - Inclusive and relevant language: the use of the concepts of autonomy, dignity and
      vulnerability in different contexts.
PG  - 203-13
LID - 10.1007/s11019-010-9242-7 [doi]
AB  - The article analyses the three terms autonomy, dignity and vulnerability. The
      relevance and practical application of the terms is tested in two spheres. First,
      as guiding principles in the area of ethics of medicines and science. Second, as 
      human rights principles, serving to guide the conduct of public policies for an
      effective realization of human rights. The article argues that all human beings
      have the same dignity, but that the autonomy--and therefore
      vulnerability--differs considerably. Simply said, with reduced autonomy comes
      increased vulnerability, implying extra attention to the protective dimensions.
      The article finds that the three terms approach the protection of human beings in
      different ways and that all are relevant and applicable in both spheres, but that
      an isolated notion of autonomy and a 'group-based' notion of vulnerability are
      not adequate.
FAU - Haugen, Hans Morten
AU  - Haugen HM
AD  - Diakonhjemmet University College, P.O. Box 184 Vindern, 0319, Oslo, Norway.
      haugen@diakonhjemmet.no
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Med Health Care Philos
JT  - Medicine, health care, and philosophy
JID - 9815900
SB  - IM
MH  - *Bioethics
MH  - Human Rights
MH  - Humans
MH  - *Language
MH  - *Personal Autonomy
MH  - *Personhood
MH  - *Vulnerable Populations
EDAT- 2010/04/13 06:00
MHDA- 2010/12/21 06:00
CRDT- 2010/04/13 06:00
PHST- 2010/04/13 06:00 [entrez]
PHST- 2010/04/13 06:00 [pubmed]
PHST- 2010/12/21 06:00 [medline]
AID - 10.1007/s11019-010-9242-7 [doi]
PST - ppublish
SO  - Med Health Care Philos. 2010 Aug;13(3):203-13. doi: 10.1007/s11019-010-9242-7.


PMID- 20383309
OWN - NLM
STAT- MEDLINE
DCOM- 20100713
LR  - 20211020
IS  - 2385-2070 (Electronic)
IS  - 1723-2007 (Linking)
VI  - 8
IP  - 2
DP  - 2010 Apr
TI  - Memories of Jean Dausset. A pioneering scientist in medical ethics.
PG  - 130-1
LID - 10.2450/2010.0019-10 [doi]
FAU - Silvestri, Giorgio
AU  - Silvestri G
LA  - eng
PT  - Biography
PT  - Historical Article
PT  - Journal Article
PL  - Italy
TA  - Blood Transfus
JT  - Blood transfusion = Trasfusione del sangue
JID - 101237479
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Allergy and Immunology/*history
MH  - Ethics, Medical/*history
MH  - France
MH  - Genetic Testing/ethics
MH  - HLA Antigens
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Nobel Prize
PS  - Dausset J
FPS - Dausset, Jean
PMC - PMC2851219
EDAT- 2010/04/13 06:00
MHDA- 2010/07/14 06:00
CRDT- 2010/04/13 06:00
PHST- 2010/04/13 06:00 [entrez]
PHST- 2010/04/13 06:00 [pubmed]
PHST- 2010/07/14 06:00 [medline]
AID - 10.2450/2010.0019-10 [doi]
PST - ppublish
SO  - Blood Transfus. 2010 Apr;8(2):130-1. doi: 10.2450/2010.0019-10.


PMID- 20383105
OWN - NLM
STAT- MEDLINE
DCOM- 20110330
LR  - 20220408
IS  - 1698-6946 (Electronic)
IS  - 1698-4447 (Linking)
VI  - 15
IP  - 6
DP  - 2010 Nov 1
TI  - Effect of orthodontic treatment on saliva, plaque and the levels of Streptococcus
      mutans and Lactobacillus.
PG  - e924-9
AB  - OBJECTIVES: The aim of this study was to identify changes in the oral environment
      with clinical, salivary and bacterial risk markers after placement of fixed
      orthodontic appliances on permanent dentition. MATERIAL AND METHODS: With ethical
      approval, we used different techniques to analyzed clinical, salivary and
      bacterial risk markers in 34 patients (mean age, 16.7+5.2 years), 14 males and 20
      females; before starting orthodontic treatment and 1 month after. Clinical risk
      markers (decayed, missing, and filled surfaces [DMFS], O'Leary's plaque index,
      and plaque pH); salivary markers (unstimulated and stimulated saliva flow rate,
      buffer capacity, pH, and occult blood in saliva) and bacterial counts
      (Streptococcus mutans and Lactobacillus). Data were analyzed by paired t-test and
      X2 test. RESULTS: This study showed that orthodontic appliances increased the
      stimulated salivary flow rate (p=0.0001), buffer capacity (p=0.0359), salivary pH
      (p=0.0246) and occult blood in saliva (p=0.0305). Bacterial levels increased
      slightly after 1 month of treatment, without statistical significance. Between
      genders, initially we observed differences in: stimulated saliva (p=0.0019),
      buffer capacity (p=0.0381) and plaque pH (p=0.0430); after treatment the
      unstimulated saliva (p=0.0026) showed differences. CONCLUSIONS: Orthodontic
      treatment changes the oral environmental factors, promotes an increase in
      stimulated flow rate, buffer capacity and salivary pH, which augment the anti
      caries activity of saliva. In contrast, increased occult blood indicated more
      gingival inflammation, apparently because augmented the retentive plaque surfaces
      and the difficult to maintain a good oral hygiene, rinsed the bleeding in saliva 
      by periodontal damage.
FAU - Lara-Carrillo, Edith
AU  - Lara-Carrillo E
AD  - Department of Orthodontics, Research Center, School of Dentistry, Universidad
      Autonoma del Estado de Mexico, Toluca, Estado de Mexico, Mexico.
      laracaedith@hotmail.com
FAU - Montiel-Bastida, Norma-Margarita
AU  - Montiel-Bastida NM
FAU - Sanchez-Perez, Leonor
AU  - Sanchez-Perez L
FAU - Alanis-Tavira, Jorge
AU  - Alanis-Tavira J
LA  - eng
PT  - Journal Article
DEP - 20101101
PL  - Spain
TA  - Med Oral Patol Oral Cir Bucal
JT  - Medicina oral, patologia oral y cirugia bucal
JID - 101231694
SB  - IM
MH  - Adolescent
MH  - Dental Plaque/*etiology
MH  - Female
MH  - Humans
MH  - Lactobacillus/*isolation & purification
MH  - Male
MH  - Orthodontic Appliances/*adverse effects
MH  - *Saliva/chemistry/metabolism/physiology
MH  - Streptococcus mutans/*isolation & purification
EDAT- 2010/04/13 06:00
MHDA- 2011/03/31 06:00
CRDT- 2010/04/13 06:00
PHST- 2009/09/11 00:00 [received]
PHST- 2010/02/11 00:00 [accepted]
PHST- 2010/04/13 06:00 [entrez]
PHST- 2010/04/13 06:00 [pubmed]
PHST- 2011/03/31 06:00 [medline]
AID - 3163 [pii]
AID - 10.4317/medoral.15.e924 [doi]
PST - epublish
SO  - Med Oral Patol Oral Cir Bucal. 2010 Nov 1;15(6):e924-9. doi:
      10.4317/medoral.15.e924.


PMID- 20383089
OWN - NLM
STAT- MEDLINE
DCOM- 20100726
LR  - 20191210
IS  - 1559-713X (Electronic)
IS  - 1559-2332 (Linking)
VI  - 5
IP  - 1
DP  - 2010 Feb
TI  - A training program for novice paramedics provides initial laryngeal mask airway
      insertion skill and improves skill retention at 6 months.
PG  - 33-9
LID - 10.1097/SIH.0b013e3181b5c3fb [doi]
AB  - INTRODUCTION: Major resuscitation councils endorse the use of the laryngeal mask 
      airway (LMA) by paramedics for lifesaving airway interventions. Learning and
      maintaining adequate skill level is important for patient safety. The aim of this
      project was to develop a training program that provides student paramedics with
      initial knowledge and experience in LMA insertion skills but equally important to
      provide ongoing skill retention. METHODS: After ethics approval and informed
      consent, 55 first year Paramedic degree students watched a manufacturer's LMA
      instruction video and practiced insertion in three different part task trainers. 
      Six months later, subjects were randomized to an intervention (reviewing the
      video and 10 minutes unsupervised practice) or control group before participating
      in a high-fidelity simulated clinical scenario. For equity of training, the
      control group received the intervention after the scenario. Main outcomes
      measured were time to insertion; success rate; and LMA skill retention (sum of
      LMA orientation; cuff inflation; bite block; securing; patient positioning; and
      overall subject performance). RESULTS: Fifty subjects completed the study. Those 
      in the intervention group displayed significantly shorter insertion times (P =
      0.029), fewer attempts to achieve success (P = 0.033), and had significantly
      higher LMA skill performance levels (P = 0.019) at 6 months. CONCLUSIONS: We
      devised a short intervention based on our training program using a video and
      practice in part task trainers. In an assessment using high-fidelity simulation, 
      we demonstrated significant improvements in maintenance of LMA insertion skills
      in student paramedics at 6 months. Our model of just-in-time assessment and
      reinforcement of training prevents skill decay and has implications for
      healthcare skills training in general.
FAU - Hein, Cindy
AU  - Hein C
AD  - SA Ambulance Service, Clinical Services, Eastwood, South Australia and Health
      Sciences (Paramedic), Flinders University, Adelaide, Australia.
      cindy2.hein@health.sa.gov.au
FAU - Owen, Harry
AU  - Owen H
FAU - Plummer, John
AU  - Plummer J
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Simul Healthc
JT  - Simulation in healthcare : journal of the Society for Simulation in Healthcare
JID - 101264408
SB  - IM
MH  - Allied Health Personnel/*education
MH  - Clinical Competence
MH  - Competency-Based Education/*methods
MH  - Humans
MH  - *Laryngeal Masks
MH  - Manikins
MH  - Program Evaluation
MH  - Proportional Hazards Models
MH  - Retention, Psychology
MH  - Time Factors
EDAT- 2010/04/13 06:00
MHDA- 2010/07/27 06:00
CRDT- 2010/04/13 06:00
PHST- 2010/04/13 06:00 [entrez]
PHST- 2010/04/13 06:00 [pubmed]
PHST- 2010/07/27 06:00 [medline]
AID - 10.1097/SIH.0b013e3181b5c3fb [doi]
AID - 01266021-201002000-00008 [pii]
PST - ppublish
SO  - Simul Healthc. 2010 Feb;5(1):33-9. doi: 10.1097/SIH.0b013e3181b5c3fb.


PMID- 20382501
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20190722
IS  - 0846-5371 (Print)
IS  - 0846-5371 (Linking)
VI  - 62
IP  - 2
DP  - 2011 May
TI  - Assessing the impact of incidental findings in a lung cancer screening study by
      using low-dose computed tomography.
PG  - 141-5
LID - 10.1016/j.carj.2010.02.008 [doi]
AB  - PURPOSE: To assess the prevalence and nature of incidental findings (IF) seen in 
      low-dose computed tomographies (LDCT) from a lung cancer screening study for
      at-risk individuals. MATERIALS AND METHODS: Radiology reports from LDCTs of 4073 
      participants of a lung cancer screening study were retrospectively reviewed for
      findings other than lung nodules, that is, IFs, which were regarded as
      actionable. The frequency, nature, and expected cost of these IFs, and their
      anticipated follow-up were estimated. RESULTS: There were 880 IFs described in
      782 study participants (19%); the median age of the participants was 62 years
      (range, 46-80 years). More IFs were found in men (55%) than in women. The
      majority of these findings were noncardiovascular (76%), for which imaging was
      suggested for 74%. There were 7 severe IFs (0.8%) that merited immediate
      attention. Seven known cancers were diagnosed from follow-ups of the IFs. The
      majority of IFs (n = 486 [55%]) would require imaging follow-up if clinically
      indicated, with an estimated total a cost of CAN$45,500 to CAN$51,000 to provide 
      initial diagnostic workup. CONCLUSION: IFs on lung cancer screening studies are
      not uncommon and frequently require imaging or other follow-up for definitive
      diagnoses and to assess their clinical relevance. The implication of IFs has to
      be considered when determining a cost-effective and ethical protocol for the
      utilisation of LDCT in a high-risk population.
CI  - 2011 Canadian Association of Radiologists. All rights reserved.
FAU - Kucharczyk, Michael J
AU  - Kucharczyk MJ
AD  - The Joint Department of Medical Imaging, University Health Network/Mt Sinai
      Hospital/Women's College Hospital, Toronto, Ontario, Canada.
FAU - Menezes, Ravi J
AU  - Menezes RJ
FAU - McGregor, Alexander
AU  - McGregor A
FAU - Paul, Narinder S
AU  - Paul NS
FAU - Roberts, Heidi C
AU  - Roberts HC
LA  - eng
PT  - Journal Article
DEP - 20100410
PL  - United States
TA  - Can Assoc Radiol J
JT  - Canadian Association of Radiologists journal = Journal l'Association canadienne
      des radiologistes
JID - 8812910
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Chi-Square Distribution
MH  - Female
MH  - Humans
MH  - *Incidental Findings
MH  - Lung Neoplasms/*diagnostic imaging
MH  - Male
MH  - Mass Screening
MH  - Middle Aged
MH  - Prevalence
MH  - Radiation Dosage
MH  - Retrospective Studies
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2010/04/13 06:00
MHDA- 2011/07/27 06:00
CRDT- 2010/04/13 06:00
PHST- 2010/01/21 00:00 [received]
PHST- 2010/02/22 00:00 [accepted]
PHST- 2010/04/13 06:00 [entrez]
PHST- 2010/04/13 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
AID - S0846-5371(10)00065-3 [pii]
AID - 10.1016/j.carj.2010.02.008 [doi]
PST - ppublish
SO  - Can Assoc Radiol J. 2011 May;62(2):141-5. doi: 10.1016/j.carj.2010.02.008. Epub
      2010 Apr 10.


PMID- 20382463
OWN - NLM
STAT- MEDLINE
DCOM- 20100714
LR  - 20220321
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 70
IP  - 12
DP  - 2010 Jun
TI  - The ethics of responsibility and ownership in decision-making about treatment for
      breast cancer: triangulation of consultation with patient and surgeon
      perspectives.
PG  - 1904-1911
LID - S0277-9536(10)00225-X [pii]
LID - 10.1016/j.socscimed.2009.12.039 [doi]
AB  - Doctors are widely encouraged to share decision-making with patients. However,
      the assumption that responsibility for decisions is an objective quantity that
      can be apportioned between doctors and patients is problematic. We studied
      treatment decisions from three perspectives simultaneously - observing
      consultations and exploring patients' and doctors' perspectives on these - to
      understand how decision-making that we observed related to participants'
      subjective experience of responsibility. We audio-recorded post-operative
      consultations in which 20 patients who had undergone initial surgery for breast
      cancer discussed further treatment with one of eight surgeons in a general
      hospital serving a socioeconomically diverse urban population in England. We
      separately interviewed each patient and their surgeon within seven days of
      consultation to explore their perspectives on decisions that had been made.
      Qualitative analysis distinguished procedurally different types of
      decision-making and explored surgeons' and patients' perspectives on each.
      Surgeons made most decisions for patients, and only explicitly offered choices
      where treatment options were clinically equivocal. Procedurally, therefore,
      shared decision-making was absent and surgeons might be regarded as having
      neglected patients' autonomy. Nevertheless, patients generally felt ownership of 
      decisions that surgeons made for them because surgeons provided justifying
      reasons and because patients knew that they could refuse. Conversely, faced with 
      choice, patients generally lacked trust in their own decisions and usually sought
      surgeons' guidance. Therefore, from the perspective of ethical frameworks that
      conceptualise patient autonomy as relational and subjective, the surgeons were
      protecting patient autonomy. Studying subjective as well as procedural elements
      of decision-making can provide a broader perspective from which to evaluate
      practitioners' decision-making behaviour.
CI  - Copyright 2010 Elsevier Ltd. All rights reserved.
FAU - Mendick, Nicola
AU  - Mendick N
AD  - Royal Liverpool and Broadgreen University Hospitals NHS Trust, United Kingdom.
FAU - Young, Bridget
AU  - Young B
AD  - University of Liverpool, Liverpool L69 3BX, United Kingdom.
FAU - Holcombe, Christopher
AU  - Holcombe C
AD  - Royal Liverpool and Broadgreen University Hospitals NHS Trust, United Kingdom.
FAU - Salmon, Peter
AU  - Salmon P
AD  - University of Liverpool, Liverpool L69 3BX, United Kingdom. Electronic address:
      psalmon@liv.ac.uk.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100319
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Attitude of Health Personnel
MH  - *Attitude to Health
MH  - Breast Neoplasms/*surgery
MH  - Decision Making/*ethics
MH  - Female
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Middle Aged
MH  - Observation
MH  - *Patient Participation
MH  - Personal Autonomy
MH  - *Physician-Patient Relations
MH  - Qualitative Research
MH  - Tape Recording
EDAT- 2010/04/13 06:00
MHDA- 2010/07/16 06:00
CRDT- 2010/04/13 06:00
PHST- 2009/08/04 00:00 [received]
PHST- 2009/11/27 00:00 [revised]
PHST- 2009/12/24 00:00 [accepted]
PHST- 2010/04/13 06:00 [entrez]
PHST- 2010/04/13 06:00 [pubmed]
PHST- 2010/07/16 06:00 [medline]
AID - S0277-9536(10)00225-X [pii]
AID - 10.1016/j.socscimed.2009.12.039 [doi]
PST - ppublish
SO  - Soc Sci Med. 2010 Jun;70(12):1904-1911. doi: 10.1016/j.socscimed.2009.12.039.
      Epub 2010 Mar 19.


PMID- 20382095
OWN - NLM
STAT- MEDLINE
DCOM- 20101220
LR  - 20100830
IS  - 1878-0946 (Electronic)
IS  - 1744-165X (Linking)
VI  - 15
IP  - 5
DP  - 2010 Oct
TI  - Ethics and hypothermia treatment.
PG  - 299-304
LID - 10.1016/j.siny.2010.03.002 [doi]
AB  - Hypothermia is the first effective neuroprotective intervention for newborns who 
      are critically ill following a life-threatening asphyxial insult. It is not
      surprising that it has raised complex and controversial ethical dilemmas for
      investigators and clinicians. Given the history of iatrogenic disasters in
      neonatology, there has been an understandable reluctance to incorporate
      hypothermia into routine clinical practice until there is persuasive evidence
      from high quality randomised trials. This article reviews ethical issues that
      arose during the design of the original clinical trials, the implications of
      accumulating evidence of safety and efficacy, and the problems of ensuring
      informed parental participation in treatment decisions.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Wyatt, John S
AU  - Wyatt JS
AD  - Institute for Women's Health, University College London, 5 University Street,
      London WC1E 6JJ, UK. profjwyatt@gmail.com
LA  - eng
GR  - Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100409
PL  - Netherlands
TA  - Semin Fetal Neonatal Med
JT  - Seminars in fetal & neonatal medicine
JID - 101240003
SB  - IM
MH  - Asphyxia Neonatorum/*complications
MH  - Clinical Protocols
MH  - Ethics, Medical
MH  - Humans
MH  - Hypothermia, Induced/*ethics/*methods
MH  - Hypoxia-Ischemia, Brain/etiology/*therapy
MH  - Infant, Newborn
MH  - Intensive Care Units, Neonatal/*ethics
MH  - Postnatal Care/*ethics
EDAT- 2010/04/13 06:00
MHDA- 2010/12/21 06:00
CRDT- 2010/04/13 06:00
PHST- 2010/04/13 06:00 [entrez]
PHST- 2010/04/13 06:00 [pubmed]
PHST- 2010/12/21 06:00 [medline]
AID - S1744-165X(10)00016-8 [pii]
AID - 10.1016/j.siny.2010.03.002 [doi]
PST - ppublish
SO  - Semin Fetal Neonatal Med. 2010 Oct;15(5):299-304. doi:
      10.1016/j.siny.2010.03.002. Epub 2010 Apr 9.


PMID- 20381749
OWN - NLM
STAT- MEDLINE
DCOM- 20100628
LR  - 20111117
IS  - 1558-4224 (Electronic)
IS  - 0749-0739 (Linking)
VI  - 26
IP  - 1
DP  - 2010 Apr
TI  - Home care for horses with chronic laminitis.
PG  - 215-23
LID - 10.1016/j.cveq.2009.12.012 [doi]
AB  - Home care for horses with chronic laminitis has been discussed rarely in the
      veterinary literature even though, at any given time, most of us have at least 1 
      chronic laminitis case in our care that is being managed at home by the owner.
      Almost all of our knowledge on this aspect of laminitis treatment has been
      gleaned through experience, by individually working through the medical, ethical,
      financial, and emotional challenges these cases can present. Much has already
      been presented on the medical management of the laminitic horse and on strategies
      for trimming and shoeing the laminitic foot. This article focuses on the other
      challenges so often faced when directing the home care of a horse with chronic
      laminitis.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Orsini, James A
AU  - Orsini JA
AD  - University of Pennsylvania, Department of Clinical Studies, New Bolton Center,
      382 West Street Road, Kennett Square, PA 19348, USA. orsini@vet.upenn.edu
FAU - Wrigley, Jennifer
AU  - Wrigley J
FAU - Riley, Patrick
AU  - Riley P
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Vet Clin North Am Equine Pract
JT  - The Veterinary clinics of North America. Equine practice
JID - 8511904
SB  - IM
MH  - Animal Husbandry/methods/standards
MH  - Animal Nutritional Physiological Phenomena/*physiology
MH  - Animals
MH  - Chronic Disease
MH  - Foot Diseases/complications/therapy/*veterinary
MH  - Hoof and Claw
MH  - Horse Diseases/*therapy
MH  - Horses
MH  - Housing, Animal/standards
MH  - Inflammation/complications/therapy/*veterinary
MH  - Pain/etiology/*veterinary
MH  - Pain Management
RF  - 22
EDAT- 2010/04/13 06:00
MHDA- 2010/06/29 06:00
CRDT- 2010/04/13 06:00
PHST- 2010/04/13 06:00 [entrez]
PHST- 2010/04/13 06:00 [pubmed]
PHST- 2010/06/29 06:00 [medline]
AID - S0749-0739(09)00108-4 [pii]
AID - 10.1016/j.cveq.2009.12.012 [doi]
PST - ppublish
SO  - Vet Clin North Am Equine Pract. 2010 Apr;26(1):215-23. doi:
      10.1016/j.cveq.2009.12.012.


PMID- 20381628
OWN - NLM
STAT- MEDLINE
DCOM- 20100929
LR  - 20220316
IS  - 1095-9564 (Electronic)
IS  - 1074-7427 (Linking)
VI  - 94
IP  - 1
DP  - 2010 Jul
TI  - Dissociating response systems: erasing fear from memory.
PG  - 30-41
LID - 10.1016/j.nlm.2010.03.004 [doi]
AB  - In addition to the extensive evidence in animals, we previously showed that
      disrupting reconsolidation by noradrenergic blockade produced amnesia for the
      original fear response in humans. Interestingly, the declarative memory for the
      fear association remained intact. These results asked for a solid replication.
      Moreover, given the constructive nature of memories, the intact recollection of
      the fear association could eventually 'rebuild' the fear memory, resulting in the
      spontaneous recovery of the fear response. Yet, perseverance of the amnesic
      effects would have substantial clinical implications, as even the most effective 
      treatments for psychiatric disorders display high percentages of relapse. Using a
      differential fear conditioning procedure in humans, we replicated our previous
      findings by showing that administering propranolol (40mg) prior to memory
      reactivation eliminated the startle fear response 24h later. But most
      importantly, this effect persisted at one month follow-up. Notably, the
      propranolol manipulation not only left the declarative memory for the acquired
      contingency untouched, but also skin conductance discrimination. In addition, a
      close association between declarative knowledge and skin conductance responses
      was found. These findings are in line with the supposed double dissociation of
      fear conditioning and declarative knowledge relative to the amygdala and
      hippocampus in humans. They support the view that skin conductance conditioning
      primarily reflects contingency learning, whereas the startle response is a rather
      specific measure of fear. Furthermore, the results indicate the absence of a
      causal link between the actual knowledge of a fear association and its fear
      response, even though they often operate in parallel. Interventions targeting the
      amygdalar fear memory may be essential in specifically and persistently dampening
      the emotional impact of fear. From a clinical and ethical perspective, disrupting
      reconsolidation points to promising interventions persistently erasing fear
      responses from trauma memory without affecting the actual recollection.
FAU - Soeter, Marieke
AU  - Soeter M
AD  - Department of Clinical Psychology, University of Amsterdam, Roetersstraat 15,
      1018 WB Amsterdam, The Netherlands.
FAU - Kindt, Merel
AU  - Kindt M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100408
PL  - United States
TA  - Neurobiol Learn Mem
JT  - Neurobiology of learning and memory
JID - 9508166
RN  - 0 (Central Nervous System Agents)
RN  - 9Y8NXQ24VQ (Propranolol)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Central Nervous System Agents/*pharmacology
MH  - Conditioning, Classical/*drug effects/physiology
MH  - Discrimination, Psychological
MH  - Extinction, Psychological/drug effects/physiology
MH  - Fear/*drug effects/physiology
MH  - Female
MH  - Follow-Up Studies
MH  - Galvanic Skin Response/drug effects
MH  - Humans
MH  - Male
MH  - Memory/*drug effects/physiology
MH  - Middle Aged
MH  - Propranolol/*pharmacology
MH  - Reflex, Startle/drug effects
MH  - Time Factors
MH  - Young Adult
EDAT- 2010/04/13 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/04/13 06:00
PHST- 2010/01/06 00:00 [received]
PHST- 2010/03/05 00:00 [revised]
PHST- 2010/03/25 00:00 [accepted]
PHST- 2010/04/13 06:00 [entrez]
PHST- 2010/04/13 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - S1074-7427(10)00062-6 [pii]
AID - 10.1016/j.nlm.2010.03.004 [doi]
PST - ppublish
SO  - Neurobiol Learn Mem. 2010 Jul;94(1):30-41. doi: 10.1016/j.nlm.2010.03.004. Epub
      2010 Apr 8.


PMID- 20381511
OWN - NLM
STAT- MEDLINE
DCOM- 20101008
LR  - 20100712
IS  - 1878-5867 (Electronic)
IS  - 0039-128X (Linking)
VI  - 75
IP  - 10
DP  - 2010 Oct
TI  - Comparative in vitro metabolism of the 'designer' steroid
      estra-4,9-diene-3,17-dione between the equine, canine and human: identification
      of target metabolites for use in sports doping control.
PG  - 643-52
LID - 10.1016/j.steroids.2010.03.010 [doi]
AB  - Effective detection of the abuse of androgenic-anabolic steroids in human and
      animal sports often requires knowledge of the drug's metabolism in order to
      target appropriate urinary metabolites. 'Designer' steroids are problematic since
      it is difficult to obtain ethical approval for in vivo metabolism studies due to 
      a lack of a toxicological profile. In this study, the in vitro metabolism of
      estra-4,9-diene-3,17-dione is reported for the first time. This is also the first
      study comparing the metabolism of a designer steroid in the three major species
      subject to sport's doping control; namely the equine, canine and human. In order 
      to allow the retrospective analysis of sample testing data, the use of a
      high-resolution (HR) accurate-mass Thermo LTQ-Orbitrap LC-MS instrument was
      employed for metabolite identification of underivatised sample extracts. The full
      scan HR-LC-MS Orbitrap data was complimented by several further experiments
      targeted at elucidating more detailed structural information for the most
      abundant metabolites. These included; HR-LC-MS/MS of the underivatised
      metabolites, functional group selective chemical derivatisation followed by full 
      scan HR-LC-MS, enzyme inhibition experiments and full scan electron ionization
      GC-MS analysis of methoxyamine-trimethylsilyl derivatives. The major metabolite
      detected in all species, and therefore the most suitable candidate for screening 
      of estra-4,9-diene-3,17-dione abuse, was proposed to be an isomer of
      17-hydroxy-estra-4,9-dien-3-one. Less significant metabolic pathways in all
      species included hydroxylation and reduction followed by hydroxylation. Reductive
      metabolism in the canine was less significant than in the other two species,
      while the equine was unique in producing a di-reduced metabolite (proposed to be 
      an isomer of estra-4,9-diene-3,17-diol) and also relatively large quantities of
      d-ring hydroxy and hydroxy-reduced metabolites.
FAU - Scarth, James P
AU  - Scarth JP
AD  - HFL Sport Science (A Quotient Bioresearch Ltd. Company), Newmarket Road, Fordham,
      Cambridgeshire, CB7 5WW, UK. jscarth@hfl.co.uk
FAU - Clarke, Adam D
AU  - Clarke AD
FAU - Teale, Philip
AU  - Teale P
FAU - Pearce, Clive M
AU  - Pearce CM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100408
PL  - United States
TA  - Steroids
JT  - Steroids
JID - 0404536
RN  - 0 (Estrenes)
SB  - IM
MH  - Animals
MH  - Chromatography, Liquid
MH  - Dogs
MH  - Doping in Sports/*prevention & control
MH  - Estrenes/*chemistry/*metabolism
MH  - Gas Chromatography-Mass Spectrometry
MH  - Horses
MH  - Humans
MH  - Magnetic Resonance Spectroscopy
MH  - Molecular Structure
MH  - Substance Abuse Detection/*methods
MH  - Tandem Mass Spectrometry
EDAT- 2010/04/13 06:00
MHDA- 2010/10/12 06:00
CRDT- 2010/04/13 06:00
PHST- 2010/02/13 00:00 [received]
PHST- 2010/03/29 00:00 [revised]
PHST- 2010/03/30 00:00 [accepted]
PHST- 2010/04/13 06:00 [entrez]
PHST- 2010/04/13 06:00 [pubmed]
PHST- 2010/10/12 06:00 [medline]
AID - S0039-128X(10)00090-5 [pii]
AID - 10.1016/j.steroids.2010.03.010 [doi]
PST - ppublish
SO  - Steroids. 2010 Oct;75(10):643-52. doi: 10.1016/j.steroids.2010.03.010. Epub 2010 
      Apr 8.


PMID- 20380904
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20151119
IS  - 1879-2057 (Electronic)
IS  - 0001-4575 (Linking)
VI  - 42
IP  - 3
DP  - 2010 May
TI  - Simulator sickness during driving simulation studies.
PG  - 788-96
LID - 10.1016/j.aap.2009.04.013 [doi]
AB  - While driving simulators are a valuable tool for assessing multiple dimensions of
      driving performance under relatively safe conditions, researchers and
      practitioners must be prepared for participants that suffer from simulator
      sickness. This paper describes multiple theories of motion sickness and presents 
      a method for assessing and reacting to simulator sickness symptoms. Results
      showed that this method identified individuals who were unable to complete a
      driving simulator study due to simulator sickness with greater than 90% accuracy 
      and that older participants had a greater likelihood of simulator sickness than
      younger participants. Possible explanations for increased symptoms experienced by
      older participants are discussed as well as implications for research ethics and 
      simulator sickness prevention.
CI  - Copyright (c) 2009 Elsevier Ltd. All rights reserved.
FAU - Brooks, Johnell O
AU  - Brooks JO
AD  - Department of Psychology, Clemson University, Clemson, SC 29634, USA.
      jobrook@clemson.edu
FAU - Goodenough, Richard R
AU  - Goodenough RR
FAU - Crisler, Matthew C
AU  - Crisler MC
FAU - Klein, Nathan D
AU  - Klein ND
FAU - Alley, Rebecca L
AU  - Alley RL
FAU - Koon, Beatrice L
AU  - Koon BL
FAU - Logan, William C Jr
AU  - Logan WC Jr
FAU - Ogle, Jennifer H
AU  - Ogle JH
FAU - Tyrrell, Richard A
AU  - Tyrrell RA
FAU - Wills, Rebekkah F
AU  - Wills RF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - Accid Anal Prev
JT  - Accident; analysis and prevention
JID - 1254476
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Automobile Driving
MH  - *Automobiles
MH  - *Computer Simulation
MH  - Eye Movements
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Motion Sickness/*etiology
MH  - Posture
MH  - Risk Factors
MH  - Statistics as Topic
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2010/04/13 06:00
MHDA- 2011/01/07 06:00
CRDT- 2010/04/13 06:00
PHST- 2008/08/13 00:00 [received]
PHST- 2008/12/01 00:00 [revised]
PHST- 2009/04/21 00:00 [accepted]
PHST- 2010/04/13 06:00 [entrez]
PHST- 2010/04/13 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
AID - S0001-4575(09)00092-X [pii]
AID - 10.1016/j.aap.2009.04.013 [doi]
PST - ppublish
SO  - Accid Anal Prev. 2010 May;42(3):788-96. doi: 10.1016/j.aap.2009.04.013.


PMID- 20380726
OWN - NLM
STAT- MEDLINE
DCOM- 20100521
LR  - 20211020
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 11
DP  - 2010 Apr 9
TI  - The use of personalized medicine for patient selection for renal transplantation:
      physicians' views on the clinical and ethical implications.
PG  - 5
LID - 10.1186/1472-6939-11-5 [doi]
AB  - BACKGROUND: The overwhelming scarcity of organs within renal transplantation
      forces researchers and transplantation teams to seek new ways to increase
      efficacy. One of the possibilities is the use of personalized medicine, an
      approach based on quantifiable and scientific factors that determine the global
      immunological risk of rejection for each patient. Although this approach can
      improve the efficacy of transplantations, it also poses a number of ethical
      questions. METHODS: The qualitative research involved 22 semi-structured
      interviews with nephrologists involved in renal transplantation, with the goal of
      determining the professionals' views about calculating the global immunological
      risk and the attendant ethical issues. RESULTS: The results demonstrate a general
      acceptance of this approach amongst the participants in the study. Knowledge of
      each patient's immunological risk could improve treatment and the post-graft
      follow-up. On the other hand, the possibility that patients might be excluded
      from transplantation poses a significant ethical issue. This approach is not seen
      as something entirely new, given the fact that medicine is increasingly
      scientific and evidence-based. Although renal transplantation incorporates
      scientific data, these physicians believe that there should always be a place for
      clinical judgment and the physician-patient relationship. CONCLUSIONS: The
      participants see the benefits of including the calculation of the global
      immunological risk within transplantation. Such data, being more precise and
      rigorous, could be of help in their clinical work. However, in spite of the use
      of such scientific data, a place must be retained for the clinical judgment that 
      allows a physician to make decisions based on medical data, professional
      expertise and knowledge of the patient. To act in the best interests of the
      patient is key to whether the calculation of the global immunological risk is
      employed.
FAU - Dion-Labrie, Marianne
AU  - Dion-Labrie M
AD  - Groupe de recherche en bioethique, Universite de Montreal, P,O, Box 6128,
      Downtown Station, Montreal, Quebec H3C3J7, Canada.
      marianne.dion-labrie@umontreal.ca
FAU - Fortin, Marie-Chantal
AU  - Fortin MC
FAU - Hebert, Marie-Josee
AU  - Hebert MJ
FAU - Doucet, Hubert
AU  - Doucet H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100409
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Adult
MH  - Aged
MH  - Decision Making/*ethics
MH  - Ethics, Clinical
MH  - Ethics, Medical
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Interdisciplinary Communication
MH  - Judgment
MH  - Kidney Transplantation/*ethics/*immunology
MH  - Male
MH  - Middle Aged
MH  - Patient Selection/*ethics
MH  - Physicians/*statistics & numerical data
MH  - Precision Medicine/ethics/methods/*statistics & numerical data
MH  - Predictive Value of Tests
MH  - Qualitative Research
MH  - Quebec
MH  - Risk Assessment
MH  - Risk Factors
MH  - Surveys and Questionnaires
MH  - Uncertainty
PMC - PMC2859770
EDAT- 2010/04/13 06:00
MHDA- 2010/05/22 06:00
CRDT- 2010/04/13 06:00
PHST- 2009/08/24 00:00 [received]
PHST- 2010/04/09 00:00 [accepted]
PHST- 2010/04/13 06:00 [entrez]
PHST- 2010/04/13 06:00 [pubmed]
PHST- 2010/05/22 06:00 [medline]
AID - 1472-6939-11-5 [pii]
AID - 10.1186/1472-6939-11-5 [doi]
PST - epublish
SO  - BMC Med Ethics. 2010 Apr 9;11:5. doi: 10.1186/1472-6939-11-5.


PMID- 20380718
OWN - NLM
STAT- MEDLINE
DCOM- 20100525
LR  - 20220321
IS  - 1471-244X (Electronic)
IS  - 1471-244X (Linking)
VI  - 10
DP  - 2010 Apr 9
TI  - INCANT: a transnational randomized trial of multidimensional family therapy
      versus treatment as usual for adolescents with cannabis use disorder.
PG  - 28
LID - 10.1186/1471-244X-10-28 [doi]
AB  - BACKGROUND: In 2003, the governments of Belgium, France, Germany, the Netherlands
      and Switzerland agreed that there was a need in Europe for a treatment programme 
      for adolescents with cannabis use disorders and other behavioural problems. Based
      on an exhaustive literature review of evidence-based treatments and an
      international experts meeting, Multidimensional Family Therapy (MDFT) was
      selected for a pilot study first, which was successful, and then for a joint,
      transnational randomized controlled trial named INCANT (INternational CAnnabis
      Need for Treatment). METHODS/DESIGN: INCANT is a randomized controlled trial
      (RCT) with an open-label, parallel group design. This study compares MDFT with
      treatment as usual (TAU) at and across sites in Brussels, Berlin, Paris, The
      Hague and Geneva. Assessments are at baseline and at 3, 6, 9 and 12 months after 
      randomization. A minimum of 450 cases in total is required; sites will recruit 60
      cases each in Belgium and Switzerland, and a maximum of 120 each in France,
      Germany and the Netherlands.Eligible for INCANT are adolescents from 13 through
      18 years of age with a cannabis use disorder (dependence or abuse), with at least
      one parent willing to take part in the treatment. Randomization is concealed to, 
      and therefore beyond control by, the researcher/site requesting it. Randomization
      is stratified as to gender, age and level of cannabis consumption.Assessments
      focus on substance use; mental function; behavioural problems; and functioning
      regarding family, school, peers and leisure time.For outcome analyses, the study 
      will use state of the art latent growth curve modelling techniques, including all
      randomized participants according to the intention-to-treat principle.INCANT has 
      been approved by the appropriate ethical boards in Belgium, France, Germany, the 
      Netherlands, Switzerland, and the University of Miami Miller School of Medicine. 
      INCANT is funded by the (federal) Ministries of Health of Belgium, Germany, the
      Netherlands, Switzerland, and by MILDT: the Mission Interministerielle de Lutte
      Contra la Drogue et de Toximanie, France. DISCUSSION: Until recently, cannabis
      use disorders in adolescents were not viewed in Europe as requiring treatment,
      and the co-occurrence of such disorders with other mental and behavioural
      problems was underestimated. This has changed now.Initially, there was doubt that
      a RCT would be feasible in treatment sectors and countries with no experience in 
      this type of study. INCANT has proven that such doubts are unjustified.
      Governments and treatment sites from the five participating countries agreed on a
      sound study protocol, and the INCANT trial is now underway as planned. TRIAL
      REGISTRATION: ISRCTN51014277.
FAU - Rigter, Henk
AU  - Rigter H
AD  - Department of Public Health, Erasmus MC, Rotterdam, the Netherlands.
      hrigter@ziggo.nl
FAU - Pelc, Isidore
AU  - Pelc I
FAU - Tossmann, Peter
AU  - Tossmann P
FAU - Phan, Olivier
AU  - Phan O
FAU - Grichting, Esther
AU  - Grichting E
FAU - Hendriks, Vincent
AU  - Hendriks V
FAU - Rowe, Cindy
AU  - Rowe C
LA  - eng
SI  - ISRCTN/ISRCTN51014277
PT  - Clinical Trial, Phase III
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20100409
PL  - England
TA  - BMC Psychiatry
JT  - BMC psychiatry
JID - 100968559
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Checklist
MH  - Cognitive Behavioral Therapy/methods
MH  - Community Mental Health Services/methods
MH  - Cross-Cultural Comparison
MH  - Europe/epidemiology
MH  - Family Therapy/*methods
MH  - Female
MH  - Humans
MH  - *International Cooperation
MH  - Male
MH  - Marijuana Abuse/epidemiology/*therapy
MH  - Pilot Projects
MH  - Psychiatric Status Rating Scales/statistics & numerical data
MH  - Research Design
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
PMC - PMC2867929
EDAT- 2010/04/13 06:00
MHDA- 2010/05/26 06:00
CRDT- 2010/04/13 06:00
PHST- 2010/03/17 00:00 [received]
PHST- 2010/04/09 00:00 [accepted]
PHST- 2010/04/13 06:00 [entrez]
PHST- 2010/04/13 06:00 [pubmed]
PHST- 2010/05/26 06:00 [medline]
AID - 1471-244X-10-28 [pii]
AID - 10.1186/1471-244X-10-28 [doi]
PST - epublish
SO  - BMC Psychiatry. 2010 Apr 9;10:28. doi: 10.1186/1471-244X-10-28.


PMID- 20380607
OWN - NLM
STAT- MEDLINE
DCOM- 20100630
LR  - 20161125
IS  - 1600-0455 (Electronic)
IS  - 0284-1851 (Linking)
VI  - 51
IP  - 6
DP  - 2010 Jul
TI  - Visceral abdominal obesity--is there an increased prevalence in men presenting
      with testicular teratoma?
PG  - 687-92
LID - 10.3109/02841851003743077 [doi]
AB  - BACKGROUND: There is evidence to suggest a link between the accumulation of
      visceral abdominal adipose tissue and an increased incidence of prostate,
      endometrial, breast, and colonic cancer. PURPOSE: To investigate whether an
      increase in ratio of visceral to subcutaneous abdominal adipose tissue is
      demonstrated in patients with testicular teratoma. MATERIAL AND METHODS:
      Following ethical approval, 22 male patients who had undergone staging computed
      tomography (CT) between 2004 and 2007 for testicular teratoma were identified
      from our database. Abdominal adipose tissue distribution for these 22 patients
      was compared with that of 22 control patients, standardized for age, sex, and
      body mass index. Visceral and subcutaneous adipose tissue volumes were calculated
      from a single axial CT slice at the level of the umbilicus. A two-sample t test
      for the difference in volume ratio between the two groups was used. A P value of 
      < 0.05 was considered statistically significant. RESULTS: There was a
      statistically significant difference in the mean ratio of visceral to
      subcutaneous volumes between the teratoma patients and controls (P=0.02). The
      ratio in teratoma patients was 1.56 times greater than seen in control patients. 
      CONCLUSION: Patients with testicular teratoma have a relatively greater
      proportion of abdominal visceral adipose tissue compared with controls. This is
      concordant with published literature for other malignancies.
FAU - Grant, Lee
AU  - Grant L
AD  - Department of Radiology, Cambridge University Teaching Hospitals NHS Foundation
      Trust, Cambridge.
FAU - Moyle, Penelope
AU  - Moyle P
FAU - Griffin, Nyree
AU  - Griffin N
FAU - Williams, Michael
AU  - Williams M
FAU - Sala, Evis
AU  - Sala E
FAU - Vasconcelos, Joana
AU  - Vasconcelos J
FAU - Dixon, Adrian
AU  - Dixon A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Acta Radiol
JT  - Acta radiologica (Stockholm, Sweden : 1987)
JID - 8706123
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Humans
MH  - Intra-Abdominal Fat/*pathology
MH  - Male
MH  - Middle Aged
MH  - Obesity, Abdominal/complications/diagnostic imaging/*epidemiology
MH  - Prevalence
MH  - Risk Factors
MH  - Teratoma/*etiology
MH  - Testicular Neoplasms/*etiology
MH  - Tomography, X-Ray Computed
MH  - Young Adult
EDAT- 2010/04/13 06:00
MHDA- 2010/07/01 06:00
CRDT- 2010/04/13 06:00
PHST- 2010/04/13 06:00 [entrez]
PHST- 2010/04/13 06:00 [pubmed]
PHST- 2010/07/01 06:00 [medline]
AID - 10.3109/02841851003743077 [doi]
PST - ppublish
SO  - Acta Radiol. 2010 Jul;51(6):687-92. doi: 10.3109/02841851003743077.


PMID- 20380597
OWN - NLM
STAT- MEDLINE
DCOM- 20100722
LR  - 20191210
IS  - 0963-8288 (Print)
IS  - 0963-8288 (Linking)
VI  - 32
IP  - 12
DP  - 2010
TI  - Human rights and rehabilitation outcomes.
PG  - 965-71
LID - 10.3109/09638281003775360 [doi]
AB  - PURPOSE: The aim of this article is to introduce rehabilitation professionals to 
      the rapidly growing literature on human rights particularly as it relates to
      health and rehabilitation. The article aims to stimulate further discussion and
      debate concerning the place of human rights in rehabilitation practice. METHOD:
      Some important milestones in the recent history of the human rights movement are 
      briefly outlined, and some important terms in the rights literature are
      explained. The Ward and Birgden model of the structure of human rights is then
      described as an example of a rights perspective that might have particular
      relevance for health and social services and rehabilitation. RESULTS: A
      rehabilitation case study is presented as an example of how the Ward and Birgden 
      model could have practical relevance when deciding on the most important outcomes
      for an individual in rehabilitation. CONCLUSION: Human rights are playing an
      increasing role in the struggle to improve health and healthcare globally. They
      also have important implications for rehabilitation practitioners and researchers
      and should form the core of any ethical framework for rehabilitation. It might
      even be argued that rights and dignity are themselves valued outcomes for
      rehabilitation.
FAU - Siegert, Richard J
AU  - Siegert RJ
AD  - Department of Palliative Care, Policy and Rehabilitation, King's College London, 
      School of Medicine at Guy's, King's College an St Thomas' Hospitals, Weston
      Education Centre, Denmark Hill, London SE5 9RJ, United Kingdom.
      richard.siegert@kcl.ac.uk
FAU - Ward, Tony
AU  - Ward T
FAU - Playford, E Diane
AU  - Playford ED
LA  - eng
PT  - Journal Article
PL  - England
TA  - Disabil Rehabil
JT  - Disability and rehabilitation
JID - 9207179
SB  - IM
MH  - Disabled Persons/psychology/*rehabilitation
MH  - *Human Rights
MH  - Humans
MH  - *Models, Theoretical
MH  - *Outcome Assessment, Health Care
MH  - Terminology as Topic
EDAT- 2010/04/13 06:00
MHDA- 2010/07/23 06:00
CRDT- 2010/04/13 06:00
PHST- 2010/04/13 06:00 [entrez]
PHST- 2010/04/13 06:00 [pubmed]
PHST- 2010/07/23 06:00 [medline]
AID - 10.3109/09638281003775360 [doi]
PST - ppublish
SO  - Disabil Rehabil. 2010;32(12):965-71. doi: 10.3109/09638281003775360.


PMID- 20380514
OWN - NLM
STAT- MEDLINE
DCOM- 20110113
LR  - 20211203
IS  - 1557-8534 (Electronic)
IS  - 1547-3287 (Linking)
VI  - 19
IP  - 8
DP  - 2010 Aug
TI  - Porcine induced pluripotent stem cells produce chimeric offspring.
PG  - 1211-20
LID - 10.1089/scd.2009.0458 [doi]
AB  - Ethical and moral issues rule out the use of human induced pluripotent stem cells
      (iPSCs) in chimera studies that would determine the full extent of their
      reprogrammed state, instead relying on less rigorous assays such as teratoma
      formation and differentiated cell types. To date, only mouse iPSC lines are known
      to be truly pluripotent. However, initial mouse iPSC lines failed to form
      chimeric offspring, but did generate teratomas and differentiated embryoid
      bodies, and thus these specific iPSC lines were not completely reprogrammed or
      truly pluripotent. Therefore, there is a need to address whether the
      reprogramming factors and process used eventually to generate chimeric mice are
      universal and sufficient to generate reprogrammed iPSC that contribute to
      chimeric offspring in additional species. Here we show that porcine mesenchymal
      stem cells transduced with 6 human reprogramming factors (POU5F1, SOX2, NANOG,
      KLF4, LIN28, and C-MYC) injected into preimplantation-stage embryos contributed
      to multiple tissue types spanning all 3 germ layers in 8 of 10 fetuses. The
      chimerism rate was high, 85.3% or 29 of 34 live offspring were chimeras based on 
      skin and tail biopsies harvested from 2- to 5-day-old pigs. The creation of
      pluripotent porcine iPSCs capable of generating chimeric offspring introduces
      numerous opportunities to study the facets significantly affecting cell
      therapies, genetic engineering, and other aspects of stem cell and developmental 
      biology.
FAU - West, Franklin D
AU  - West FD
AD  - Regenerative Bioscience Center, University of Georgia, Athens, Georgia 30602,
      USA.
FAU - Terlouw, Steve L
AU  - Terlouw SL
FAU - Kwon, Dae Jin
AU  - Kwon DJ
FAU - Mumaw, Jennifer L
AU  - Mumaw JL
FAU - Dhara, Sujoy K
AU  - Dhara SK
FAU - Hasneen, Kowser
AU  - Hasneen K
FAU - Dobrinsky, John R
AU  - Dobrinsky JR
FAU - Stice, Steven L
AU  - Stice SL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Stem Cells Dev
JT  - Stem cells and development
JID - 101197107
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
RN  - 0 (Fetal Proteins)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (KLF4 protein, human)
RN  - 0 (Klf4 protein, mouse)
RN  - 0 (Kruppel-Like Factor 4)
RN  - 0 (Kruppel-Like Transcription Factors)
RN  - 0 (Lin28A protein, human)
RN  - 0 (MYC protein, human)
RN  - 0 (NANOG protein, human)
RN  - 0 (Nanog Homeobox Protein)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Octamer Transcription Factor-3)
RN  - 0 (POU5F1 protein, human)
RN  - 0 (Proto-Oncogene Proteins c-myc)
RN  - 0 (RNA-Binding Proteins)
RN  - 0 (SOX2 protein, human)
RN  - 0 (SOXB1 Transcription Factors)
RN  - 0 (T-Box Domain Proteins)
RN  - 0 (alpha-Fetoproteins)
RN  - 169238-82-8 (Neurogenic differentiation factor 1)
RN  - EQ43SC3GDB (Brachyury protein)
SB  - IM
MH  - Animal Structures/cytology/metabolism
MH  - Animals
MH  - Animals, Newborn/abnormalities/metabolism
MH  - Basic Helix-Loop-Helix Transcription Factors/genetics
MH  - Blastocyst/cytology
MH  - Cell Differentiation/genetics
MH  - Chimera/abnormalities/*embryology/metabolism
MH  - Embryoid Bodies/cytology
MH  - Fetal Proteins/genetics
MH  - Fetus/cytology/metabolism
MH  - Gene Expression/genetics
MH  - Homeodomain Proteins/genetics
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*cytology/metabolism/transplantation
MH  - Kruppel-Like Factor 4
MH  - Kruppel-Like Transcription Factors/genetics
MH  - Mesenchymal Stem Cells/cytology
MH  - Nanog Homeobox Protein
MH  - Nerve Tissue Proteins/genetics
MH  - Octamer Transcription Factor-3/genetics/metabolism
MH  - Proto-Oncogene Proteins c-myc/genetics
MH  - RNA-Binding Proteins/genetics
MH  - SOXB1 Transcription Factors/genetics/metabolism
MH  - *Sus scrofa
MH  - T-Box Domain Proteins/genetics
MH  - Transduction, Genetic
MH  - alpha-Fetoproteins/genetics
EDAT- 2010/04/13 06:00
MHDA- 2011/01/14 06:00
CRDT- 2010/04/13 06:00
PHST- 2010/04/13 06:00 [entrez]
PHST- 2010/04/13 06:00 [pubmed]
PHST- 2011/01/14 06:00 [medline]
AID - 10.1089/scd.2009.0458 [doi]
PST - ppublish
SO  - Stem Cells Dev. 2010 Aug;19(8):1211-20. doi: 10.1089/scd.2009.0458.


PMID- 20379937
OWN - NLM
STAT- MEDLINE
DCOM- 20100510
LR  - 20100409
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 4
DP  - 2010 Apr
TI  - Reflecting on the nature of Confucian ethics.
PG  - 84-6
LID - 10.1080/15265161003686498 [doi]
FAU - Tsai, Daniel Fu-Chang
AU  - Tsai DF
AD  - National Taiwan University College of Medicine, National Taiwan University
      Hospital, Taipei, 10051, Taiwan. fctsai@ntu.edu.tw
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2010 Apr;10(4):62-70. PMID: 20379929
MH  - *Confucianism
MH  - Ethical Analysis
MH  - *Ethical Theory
MH  - Genetic Engineering/ethics
MH  - Genetic Enhancement/*ethics
MH  - Humans
MH  - *Principle-Based Ethics
MH  - *Virtues
EDAT- 2010/04/10 06:00
MHDA- 2010/05/11 06:00
CRDT- 2010/04/10 06:00
PHST- 2010/04/10 06:00 [entrez]
PHST- 2010/04/10 06:00 [pubmed]
PHST- 2010/05/11 06:00 [medline]
AID - 920987477 [pii]
AID - 10.1080/15265161003686498 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Apr;10(4):84-6. doi: 10.1080/15265161003686498.


PMID- 20379929
OWN - NLM
STAT- MEDLINE
DCOM- 20100510
LR  - 20100409
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 4
DP  - 2010 Apr
TI  - A Confucian reflection on genetic enhancement.
PG  - 62-70
LID - 10.1080/15265161003637541 [doi]
AB  - This essay explores a proper Confucian vision on genetic enhancement. It argues
      that while Confucians can accept a formal starting point that Michael Sandel
      proposes in his ethics of giftedness, namely, that children should be taken as
      gifts, Confucians cannot adopt his generalist strategy. The essay provides a
      Confucian full ethics of giftedness by addressing a series of relevant questions,
      such as what kind of gifts children are, where the gifts are from, in which way
      they are given, and for what purpose they are given. It indicates that Confucians
      should sort out different types of enhancement and bring them to the test of the 
      Confucian values in terms of both Confucian virtue principles and specific ritual
      rules. It concludes that Confucians can accept some types of enhancement but must
      reject others.
FAU - Fan, Ruiping
AU  - Fan R
AD  - City University of Hong Kong, Department of Public & Social Administration,
      Kowloon, Hong Kong. safan@cityu.edu.hk
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CIN - Am J Bioeth. 2010 Apr;10(4):W6-8. PMID: 20379912
CIN - Am J Bioeth. 2010 Apr;10(4):71-2. PMID: 20379930
CIN - Am J Bioeth. 2010 Apr;10(4):73-4. PMID: 20379931
CIN - Am J Bioeth. 2010 Apr;10(4):74-6. PMID: 20379932
CIN - Am J Bioeth. 2010 Apr;10(4):76-8. PMID: 20379933
CIN - Am J Bioeth. 2010 Apr;10(4):78-80. PMID: 20379934
CIN - Am J Bioeth. 2010 Apr;10(4):80-2. PMID: 20379935
CIN - Am J Bioeth. 2010 Apr;10(4):82-4. PMID: 20379936
CIN - Am J Bioeth. 2010 Apr;10(4):84-6. PMID: 20379937
MH  - China
MH  - *Confucianism
MH  - Ethical Analysis
MH  - Ethical Theory
MH  - Ethics, Medical
MH  - *Family
MH  - Genetic Engineering/ethics
MH  - Genetic Enhancement/*ethics
MH  - *Gift Giving/ethics
MH  - *Human Characteristics
MH  - Humans
MH  - *Love
MH  - Moral Obligations
MH  - *Parent-Child Relations
MH  - Parents
MH  - Politics
MH  - *Virtues
MH  - Western World
EDAT- 2010/04/10 06:00
MHDA- 2010/05/11 06:00
CRDT- 2010/04/10 06:00
PHST- 2010/04/10 06:00 [entrez]
PHST- 2010/04/10 06:00 [pubmed]
PHST- 2010/05/11 06:00 [medline]
AID - 920988870 [pii]
AID - 10.1080/15265161003637541 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Apr;10(4):62-70. doi: 10.1080/15265161003637541.


PMID- 20379925
OWN - NLM
STAT- MEDLINE
DCOM- 20100510
LR  - 20100409
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 4
DP  - 2010 Apr
TI  - Dueling ethical frameworks for allocating health resources.
PG  - 54-6
LID - 10.1080/15265161003632989 [doi]
FAU - Vawter, Dorothy E
AU  - Vawter DE
AD  - Minnesota Center for Health Care Ethics, St. Paul, MN 55105, USA.
      vawter@mnhealthethics.org
FAU - Garrett, J Eline
AU  - Garrett JE
FAU - Gervais, Karen G
AU  - Gervais KG
FAU - Prehn, Angela Witt
AU  - Prehn AW
FAU - DeBruin, Debra A
AU  - DeBruin DA
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2010 Apr;10(4):37-45. PMID: 20379920
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - *Aging
MH  - Choice Behavior/ethics
MH  - Decision Making/*ethics
MH  - Disease Outbreaks/ethics
MH  - *Ethical Theory
MH  - Health Care Rationing/*ethics
MH  - Humans
MH  - Infant
MH  - Life Expectancy
MH  - Minnesota
MH  - *Morals
MH  - Patient Selection/*ethics
MH  - Prognosis
MH  - Quality of Life
MH  - Resource Allocation/ethics
MH  - *Social Justice
MH  - Social Values
MH  - United States
MH  - Young Adult
EDAT- 2010/04/10 06:00
MHDA- 2010/05/11 06:00
CRDT- 2010/04/10 06:00
PHST- 2010/04/10 06:00 [entrez]
PHST- 2010/04/10 06:00 [pubmed]
PHST- 2010/05/11 06:00 [medline]
AID - 920987891 [pii]
AID - 10.1080/15265161003632989 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Apr;10(4):54-6. doi: 10.1080/15265161003632989.


PMID- 20379917
OWN - NLM
STAT- MEDLINE
DCOM- 20100510
LR  - 20100409
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 4
DP  - 2010 Apr
TI  - Ethics of translation: MOLST and electronic advance directives.
PG  - 30-2
LID - 10.1080/15265161003633003 [doi]
FAU - Aultman, Julie M
AU  - Aultman JM
AD  - Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272, USA.
      julieaultman@yahoo.com
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2010 Apr;10(4):3-22. PMID: 20379910
MH  - *Advance Directives/ethics
MH  - Cardiopulmonary Resuscitation/ethics
MH  - Decision Making/ethics
MH  - *Decision Making, Computer-Assisted
MH  - *Electronics, Medical
MH  - Humans
MH  - *Life Support Care/ethics
MH  - *Resuscitation Orders
MH  - Right to Die
MH  - *Terminal Care/ethics
MH  - United States
EDAT- 2010/04/10 06:00
MHDA- 2010/05/11 06:00
CRDT- 2010/04/10 06:00
PHST- 2010/04/10 06:00 [entrez]
PHST- 2010/04/10 06:00 [pubmed]
PHST- 2010/05/11 06:00 [medline]
AID - 920991853 [pii]
AID - 10.1080/15265161003633003 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Apr;10(4):30-2. doi: 10.1080/15265161003633003.


PMID- 20379357
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1687-9597 (Electronic)
IS  - 1687-9597 (Linking)
VI  - 2010
DP  - 2010
TI  - Fertility preservation for cancer patients: a review.
PG  - 160386
LID - 10.1155/2010/160386 [doi]
AB  - Infertility can arise as a consequence of treatment of oncological conditions.
      The parallel and continued improvement in both the management of oncology and
      fertility cases in recent times has brought to the fore-front the potential for
      fertility preservation in patients being treated for cancer. Oncologists must be 
      aware of situations where their treatment will affect fertility in patients who
      are being treated for cancer and they must also be aware of the pathways
      available for procedures such as cryopreservation of gametes and/or embryos.
      Improved cancer care associated with increased cure rates and long term survival,
      coupled with advances in fertility treatment means that it is now imperative that
      fertility preservation is considered as part of the care offered to these
      patients. This can only be approached within a multidisciplinary setting. There
      are obvious challenges that still remain to be resolved, especially in the area
      of fertility preservation in prepubertal patients. These include ethical issues, 
      such as valid consent and research in the area of tissue retrieval,
      cryopreservation, and transplantation.
FAU - Ajala, Tosin
AU  - Ajala T
AD  - Department of Obstetrics and Gynaecology, Basingstoke and North Hampshire NHS
      Trust, Basingstoke RG24 9NA, UK.
FAU - Rafi, Junaid
AU  - Rafi J
FAU - Larsen-Disney, Peter
AU  - Larsen-Disney P
FAU - Howell, Richard
AU  - Howell R
LA  - eng
PT  - Journal Article
DEP - 20100331
PL  - United States
TA  - Obstet Gynecol Int
JT  - Obstetrics and gynecology international
JID - 101517078
PMC - PMC2850134
EDAT- 2010/04/10 06:00
MHDA- 2010/04/10 06:01
CRDT- 2010/04/10 06:00
PHST- 2009/09/28 00:00 [received]
PHST- 2010/03/02 00:00 [accepted]
PHST- 2010/04/10 06:00 [entrez]
PHST- 2010/04/10 06:00 [pubmed]
PHST- 2010/04/10 06:01 [medline]
AID - 10.1155/2010/160386 [doi]
PST - ppublish
SO  - Obstet Gynecol Int. 2010;2010:160386. doi: 10.1155/2010/160386. Epub 2010 Mar 31.


PMID- 20379244
OWN - NLM
STAT- MEDLINE
DCOM- 20100720
LR  - 20161125
IS  - 1476-5373 (Electronic)
IS  - 0007-0610 (Linking)
VI  - 208
IP  - 7
DP  - 2010 Apr 10
TI  - BDA special care case mix model.
PG  - 291-6
LID - 10.1038/sj.bdj.2010.294 [doi]
AB  - Routine dental care provided in special care dentistry is complicated by patient 
      specific factors which increase the time taken and costs of treatment. The BDA
      have developed and conducted a field trial of a case mix tool to measure this
      complexity. For each episode of care the case mix tool assesses the following on 
      a four point scale: 'ability to communicate', 'ability to cooperate', 'medical
      status', 'oral risk factors', 'access to oral care' and 'legal and ethical
      barriers to care'. The tool is reported to be easy to use and captures sufficient
      detail to discriminate between types of service and special care dentistry
      provided. It offers potential as a simple to use and clinically relevant source
      of performance management and commissioning data. This paper describes the model,
      demonstrates how it is currently being used, and considers future developments in
      its use.
FAU - Bateman, P
AU  - Bateman P
AD  - Dental Services, Sheffield PCT, Firth Park Clinic, North Quadrant, Sheffield, S5 
      6NU. peter.bateman@sheffi eldpct.nhs.uk
FAU - Arnold, C
AU  - Arnold C
FAU - Brown, R
AU  - Brown R
FAU - Foster, L V
AU  - Foster LV
FAU - Greening, S
AU  - Greening S
FAU - Monaghan, N
AU  - Monaghan N
FAU - Zoitopoulos, L
AU  - Zoitopoulos L
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br Dent J
JT  - British dental journal
JID - 7513219
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Child
MH  - Child, Preschool
MH  - Communication
MH  - Community Dentistry/economics/legislation & jurisprudence/organization &
      administration
MH  - Contract Services/economics/legislation & jurisprudence/organization &
      administration
MH  - Cooperative Behavior
MH  - Dental Care for Disabled/economics/legislation & jurisprudence/*organization &
      administration
MH  - Dentist-Patient Relations
MH  - *Diagnosis-Related Groups
MH  - Episode of Care
MH  - Ethics, Dental
MH  - Health Services Accessibility/economics/legislation & jurisprudence/organization 
      & administration
MH  - Health Status
MH  - Health Status Indicators
MH  - Humans
MH  - Infant
MH  - Middle Aged
MH  - Needs Assessment
MH  - Oral Health
MH  - Risk Factors
MH  - Societies, Dental
MH  - State Dentistry/economics/legislation & jurisprudence/organization &
      administration
MH  - United Kingdom
MH  - Young Adult
EDAT- 2010/04/10 06:00
MHDA- 2010/07/21 06:00
CRDT- 2010/04/10 06:00
PHST- 2010/02/19 00:00 [accepted]
PHST- 2010/04/10 06:00 [entrez]
PHST- 2010/04/10 06:00 [pubmed]
PHST- 2010/07/21 06:00 [medline]
AID - sj.bdj.2010.294 [pii]
AID - 10.1038/sj.bdj.2010.294 [doi]
PST - ppublish
SO  - Br Dent J. 2010 Apr 10;208(7):291-6. doi: 10.1038/sj.bdj.2010.294.


PMID- 20378888
OWN - NLM
STAT- MEDLINE
DCOM- 20100820
LR  - 20100409
IS  - 0748-321X (Print)
IS  - 0748-321X (Linking)
VI  - 37
IP  - 1
DP  - 2010 Spring
TI  - A commentary on the animal welfare symposium, with possible actions.
PG  - 107-13
LID - 10.3138/jvme.37.1.107 [doi]
AB  - The author analyzes the common themes addressed by speakers at the AVMA/AAVMC
      conference on animal welfare, adding a few comments of his own. These themes can 
      be summarized in the basic statement that "the veterinary profession has a
      responsibility to its members and to the public to provide and ensure a good
      education in animal welfare science, ethics, and public policy and law."
      Veterinarians have a special role as animals' advocates for several reasons: they
      have the knowledge base and the required skills and commitment to fulfill this
      role; they have earned the confidence and respect of the constituents they serve;
      they are the professionals to whom policy makers logically turn for guidance on
      animal health and welfare issues. Therefore, the veterinary profession has an
      opportunity to reassert itself as the advocate not only for animals' physical
      health but also for their mental health and welfare. To be successful, however,
      the profession's leadership and members must engage without delay in advancing
      educational programs, research projects, and outreach to solidify authority in
      this key component of veterinary medicine.
FAU - Morton, David B
AU  - Morton DB
AD  - Biomedical Sciences & Biomedical Ethics, University of Birmingham, UK.
      general-practice@bham.ac.uk
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - J Vet Med Educ
JT  - Journal of veterinary medical education
JID - 7610519
SB  - IM
MH  - Animal Welfare/*ethics
MH  - Animals
MH  - Education, Veterinary/ethics/methods
MH  - Humans
MH  - Public Policy
MH  - Social Responsibility
MH  - United States
MH  - Veterinarians/*ethics/psychology
EDAT- 2010/04/10 06:00
MHDA- 2010/08/21 06:00
CRDT- 2010/04/10 06:00
PHST- 2010/04/10 06:00 [entrez]
PHST- 2010/04/10 06:00 [pubmed]
PHST- 2010/08/21 06:00 [medline]
AID - 37/1/107 [pii]
AID - 10.3138/jvme.37.1.107 [doi]
PST - ppublish
SO  - J Vet Med Educ. 2010 Spring;37(1):107-13. doi: 10.3138/jvme.37.1.107.


PMID- 20378887
OWN - NLM
STAT- MEDLINE
DCOM- 20100820
LR  - 20201209
IS  - 0748-321X (Print)
IS  - 0748-321X (Linking)
VI  - 37
IP  - 1
DP  - 2010 Spring
TI  - Words matter: implications of semantics and imagery in framing animal-welfare
      issues.
PG  - 101-6
LID - 10.3138/jvme.37.1.101 [doi]
AB  - As criticisms of contemporary farm-animal production escalate, scholars have
      begun to scrutinize the imagery and linguistic techniques used to frame animal
      issues and their implications. Pro-animal rights groups typically present animal 
      use as unnecessary, oppressive, and exploitive and adopt themes of compassion and
      protection to engage the public. In contrast, anti-animal rights groups represent
      animal use as necessary for human benefit and often situate animal and human
      interests as being incompatible. Overly simplistic, polarized representations of 
      animal issues therefore emerge. Several analyses, however, have indicated that
      the discourse on farm-animal production fails to either make a compelling ethical
      argument for animal agriculture or address the ethical concerns raised by
      animal-rights activists. Proponents of animal agriculture are argued to
      consistently misrepresent animal production practices and portray animals as
      inanimate objects, reflecting lack of genuine concern for animal suffering or
      welfare. Thus far, the veterinary community has escaped this level of scrutiny.
      However, veterinarians are often viewed as being connected to animal agriculture.
      As veterinarians strive to assume leadership in animal welfare, it is useful for 
      the profession to recognize that, as is the case for members of the animal
      sciences and industries, some aspects of its discourse may contradict its
      professed values and beliefs about animal care and welfare. Analysis of this
      discourse affords the opportunity to more effectively engage with the public on
      animal-welfare issues and to develop a compelling narrative of the role of
      animals in an increasingly urban society.
FAU - Croney, Candace C
AU  - Croney CC
AD  - Department of Veterinary Preventive Medicine, The Ohio State University,
      Columbus, OH 43210, USA. croney.1@osu.edu
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - J Vet Med Educ
JT  - Journal of veterinary medical education
JID - 7610519
SB  - IM
MH  - Animal Welfare/*organization & administration
MH  - Animals
MH  - Human-Animal Bond
MH  - Humans
MH  - Imagery, Psychotherapy
MH  - Semantics
MH  - Veterinary Medicine/standards
EDAT- 2010/04/10 06:00
MHDA- 2010/08/21 06:00
CRDT- 2010/04/10 06:00
PHST- 2010/04/10 06:00 [entrez]
PHST- 2010/04/10 06:00 [pubmed]
PHST- 2010/08/21 06:00 [medline]
AID - 37/1/101 [pii]
AID - 10.3138/jvme.37.1.101 [doi]
PST - ppublish
SO  - J Vet Med Educ. 2010 Spring;37(1):101-6. doi: 10.3138/jvme.37.1.101.


PMID- 20378884
OWN - NLM
STAT- MEDLINE
DCOM- 20100820
LR  - 20161125
IS  - 0748-321X (Print)
IS  - 0748-321X (Linking)
VI  - 37
IP  - 1
DP  - 2010 Spring
TI  - Animal welfare: an aspect of care, sustainability, and food quality required by
      the public.
PG  - 83-8
LID - 10.3138/jvme.37.1.83 [doi]
AB  - People feel that they have obligations to the animals that they use and show some
      degree of care behavior toward them. In addition, animal welfare is an aspect of 
      our decisions about whether animal-usage systems are sustainable. A system that
      results in poor welfare is unsustainable because it is unacceptable to many
      people. The quality of animal products is now judged in relation to the ethics of
      production, including impact on the animal's welfare on immediate features and on
      consequences for consumers. Because genetic selection and management for high
      productivity may lead to more disease and other aspects of poor welfare,
      consumers demand some major changes in animal-production systems. In teaching
      animal welfare, a clear definition that can be related to other concepts such as 
      needs, health, and stress is needed. The methodology for the scientific
      assessment of animal welfare has developed rapidly in recent years and has become
      a major scientific discipline. No veterinary degree course should be approved
      unless a full course on the science of animal welfare and relevant aspects of
      ethics and law have been taught. Each country should have a national advisory
      committee on animal-welfare science, made up of independent scientists, including
      veterinarians, who can write impartial reviews of the state of scientific
      knowledge.
FAU - Broom, Donald M
AU  - Broom DM
AD  - Department of Veterinary Medicine, University of Cambridge, UK. dmb16@cam.ac.uk
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - J Vet Med Educ
JT  - Journal of veterinary medical education
JID - 7610519
SB  - IM
MH  - Animal Feed/*standards
MH  - Animal Welfare/*standards
MH  - Animals
MH  - *Community Participation
MH  - Humans
MH  - Teaching/methods
EDAT- 2010/04/10 06:00
MHDA- 2010/08/21 06:00
CRDT- 2010/04/10 06:00
PHST- 2010/04/10 06:00 [entrez]
PHST- 2010/04/10 06:00 [pubmed]
PHST- 2010/08/21 06:00 [medline]
AID - 37/1/83 [pii]
AID - 10.3138/jvme.37.1.83 [doi]
PST - ppublish
SO  - J Vet Med Educ. 2010 Spring;37(1):83-8. doi: 10.3138/jvme.37.1.83.


PMID- 20378883
OWN - NLM
STAT- MEDLINE
DCOM- 20100820
LR  - 20100409
IS  - 0748-321X (Print)
IS  - 0748-321X (Linking)
VI  - 37
IP  - 1
DP  - 2010 Spring
TI  - Educating the public: information or persuasion?
PG  - 74-82
LID - 10.3138/jvme.37.1.74 [doi]
AB  - Beliefs form a major component of public attitudes, and attitudes have a role in 
      determining how people behave as consumers and as citizens. Their behavior in
      turn affects the commercial viability and even the sustainability of animal
      industries. Beliefs are subjective facts, that is, matters that individuals
      consider to be true. The process of informing the community necessarily involves 
      changing beliefs and, to this extent, persuasion. Education strategies relating
      to welfare issues depend on the target group and the desired outcome. Target
      groups include farmers, post-farm gatekeepers including transport drivers and
      abattoir workers, carers of companion animals, legislators and regulators,
      retailers, and the general community. These target groups may not be homogeneous,
      but each nevertheless has identifiable needs for knowledge and skills relevant to
      welfare. The approach that is likely to be most effective is to provide
      appropriately targeted dispassionate and factual information to the community. In
      this way, when debates about animal welfare occur, all the
      stakeholders--including animal-rights groups, retailers, farmers, legislators,
      and regulators--who are involved in the debate are more likely to produce good
      outcomes if discussion is based on a shared understanding of what current
      practices are and what science can reveal about welfare. Given that the mass
      media are the preferred source of information, the use of science-based media
      coverage and informed ethical debate is likely to have the best effect, albeit
      over a fairly long time frame.
FAU - Coleman, Grahame John
AU  - Coleman GJ
AD  - School of Psychology and Psychiatry, Monash University, Clayton, Victoria,
      Australia. grahame.coleman@med.monash.edu.au
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - J Vet Med Educ
JT  - Journal of veterinary medical education
JID - 7610519
SB  - IM
MH  - Animal Husbandry
MH  - Animal Rights
MH  - *Animal Welfare
MH  - Animals
MH  - Animals, Domestic
MH  - *Attitude
MH  - Behavior
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Perception
EDAT- 2010/04/10 06:00
MHDA- 2010/08/21 06:00
CRDT- 2010/04/10 06:00
PHST- 2010/04/10 06:00 [entrez]
PHST- 2010/04/10 06:00 [pubmed]
PHST- 2010/08/21 06:00 [medline]
AID - 37/1/74 [pii]
AID - 10.3138/jvme.37.1.74 [doi]
PST - ppublish
SO  - J Vet Med Educ. 2010 Spring;37(1):74-82. doi: 10.3138/jvme.37.1.74.


PMID- 20378882
OWN - NLM
STAT- MEDLINE
DCOM- 20100820
LR  - 20100409
IS  - 0748-321X (Print)
IS  - 0748-321X (Linking)
VI  - 37
IP  - 1
DP  - 2010 Spring
TI  - Teaching animal welfare in some veterinary schools in Latin America.
PG  - 69-73
LID - 10.3138/jvme.37.1.69 [doi]
AB  - Animal welfare is an emerging topic in Latin America because of its impact on
      animal health, international trade, industry economic viability, and consumer
      perceptions. To enable veterinarians to be primary promoters of animal welfare,
      their training must include competencies in ethics, ethology, research, and
      public policy. During the past 10 years, animal welfare has gradually been
      incorporated into the curricula of several schools of veterinary medicine in
      Chile and other Latin American countries. Inclusion in these curricula is limited
      by a shortage of knowledgeable instructors. Research sustains inclusion of animal
      welfare in the curricula, but funding for research is often lacking.
FAU - Tadich, Nestor A
AU  - Tadich NA
AD  - Faculty of Veterinary Science, Universidad Austral de Chile, Valdivia, Chile.
      decanvet@uach.cl
FAU - Molento, Carla F M
AU  - Molento CF
FAU - Gallo, Carmen B
AU  - Gallo CB
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - J Vet Med Educ
JT  - Journal of veterinary medical education
JID - 7610519
SB  - IM
MH  - Animal Husbandry/education/standards
MH  - Animal Welfare
MH  - Animals
MH  - Curriculum
MH  - Education, Veterinary
MH  - Humans
MH  - Latin America
MH  - Research/education
MH  - Teaching/*methods
EDAT- 2010/04/10 06:00
MHDA- 2010/08/21 06:00
CRDT- 2010/04/10 06:00
PHST- 2010/04/10 06:00 [entrez]
PHST- 2010/04/10 06:00 [pubmed]
PHST- 2010/08/21 06:00 [medline]
AID - 37/1/69 [pii]
AID - 10.3138/jvme.37.1.69 [doi]
PST - ppublish
SO  - J Vet Med Educ. 2010 Spring;37(1):69-73. doi: 10.3138/jvme.37.1.69.


PMID- 20378875
OWN - NLM
STAT- MEDLINE
DCOM- 20100820
LR  - 20161125
IS  - 0748-321X (Print)
IS  - 0748-321X (Linking)
VI  - 37
IP  - 1
DP  - 2010 Spring
TI  - Evolution of animal-welfare education for veterinary students.
PG  - 30-5
LID - 10.3138/jvme.37.1.30 [doi]
AB  - Animal-welfare education is an evolving component of the veterinary curriculum.
      Although different veterinary schools may cover different elements of the subject
      and teach it in many different ways, it is important to recognize that this
      multidisciplinary subject is evolving rapidly. For example, welfare science is
      beginning to examine the quantification of positive welfare or a good life in
      addition to evaluating harms associated with different husbandry systems.
      Although the curriculum is under continual pressure, the drivers (policy makers, 
      student expectations, and trade requirements) for including animal welfare in the
      course are likely to increase. Some core components of an animal-welfare course
      are important to include in all veterinary curriculums. This would include an
      appreciation of the difference between welfare science, ethics, and standards.
FAU - Main, David C J
AU  - Main DC
AD  - Department of Clinical Veterinary Science, University of Bristol, Langford,
      Bristol, UK. d.c.j.main@bristol.ac.uk
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - J Vet Med Educ
JT  - Journal of veterinary medical education
JID - 7610519
SB  - IM
MH  - Animal Husbandry/ethics/standards
MH  - Animal Welfare/ethics/*standards
MH  - Animals
MH  - *Curriculum
MH  - Education, Veterinary/*standards
MH  - Humans
MH  - Learning
MH  - Legislation, Veterinary/ethics/standards
MH  - Schools, Veterinary/standards
MH  - Teaching/methods
MH  - United Kingdom
MH  - *Veterinary Medicine
EDAT- 2010/04/10 06:00
MHDA- 2010/08/21 06:00
CRDT- 2010/04/10 06:00
PHST- 2010/04/10 06:00 [entrez]
PHST- 2010/04/10 06:00 [pubmed]
PHST- 2010/08/21 06:00 [medline]
AID - 37/1/30 [pii]
AID - 10.3138/jvme.37.1.30 [doi]
PST - ppublish
SO  - J Vet Med Educ. 2010 Spring;37(1):30-5. doi: 10.3138/jvme.37.1.30.


PMID- 20378872
OWN - NLM
STAT- MEDLINE
DCOM- 20100820
LR  - 20101118
IS  - 0748-321X (Print)
IS  - 0748-321X (Linking)
VI  - 37
IP  - 1
DP  - 2010 Spring
TI  - Animal ethics and public expectations: the North American outlook.
PG  - 13-21
LID - 10.3138/jvme.37.1.13 [doi]
AB  - Recent social science research on the American public's attitudes toward the
      welfare of food animals tracks closely with a difficult-to-resolve philosophical 
      issue. One side interprets welfare in terms of the way that a given animal is
      faring in a production setting. This view emphasizes the animal's medical
      condition and cognitive well-being. The other view derives norms for welfare from
      a conception of what is natural for an animal of a given species. This view
      presumes that an animal does well when it is living according to its nature. Both
      of these approaches reflect traditions of ethical thinking that have long
      histories of application to human and non-human animals, and each appears to have
      a significant constituency among the public. Each view implies a different
      approach and different standards for livestock welfare. The fact that this
      philosophical debate has a history dating back to ancient times suggests that it 
      will not be resolved easily.
FAU - Thompson, Paul B
AU  - Thompson PB
AD  - Agricultural, Food and Community Ethics at Michigan State University, East
      Lansing, MI 48824, USA. thomp649@msu.edu
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - J Vet Med Educ
JT  - Journal of veterinary medical education
JID - 7610519
SB  - IM
MH  - Animal Feed/standards
MH  - Animal Welfare/*standards
MH  - Animals
MH  - *Animals, Domestic
MH  - Attitude
MH  - Biological Evolution
MH  - Diet, Vegetarian
MH  - *Ethics
MH  - Humans
MH  - North America
MH  - Philosophy
EDAT- 2010/04/10 06:00
MHDA- 2010/08/21 06:00
CRDT- 2010/04/10 06:00
PHST- 2010/04/10 06:00 [entrez]
PHST- 2010/04/10 06:00 [pubmed]
PHST- 2010/08/21 06:00 [medline]
AID - 37/1/13 [pii]
AID - 10.3138/jvme.37.1.13 [doi]
PST - ppublish
SO  - J Vet Med Educ. 2010 Spring;37(1):13-21. doi: 10.3138/jvme.37.1.13.


PMID- 20378871
OWN - NLM
STAT- MEDLINE
DCOM- 20100820
LR  - 20100409
IS  - 0748-321X (Print)
IS  - 0748-321X (Linking)
VI  - 37
IP  - 1
DP  - 2010 Spring
TI  - Animal welfare: a complex domestic and international public-policy issue--who are
      the key players?
PG  - 3-12
LID - 10.3138/jvme.37.1.3 [doi]
AB  - Animal-welfare issues are usually portrayed in the media in a black-and-white
      fashion, with simple, single-perspective solutions proposed for what are often,
      in fact, complex policy issues. In this article, we argue that animal welfare is 
      a multifaceted international and domestic public-policy issue that must take
      account of not only scientific, ethical, and economic issues but also religious, 
      cultural, and international trade policy considerations. Management of animal
      welfare at a government policy level also requires an approach based on
      incremental change. Such change must be both science based and ethically
      principled, and the rate of change must recognize both the expectations of
      society and the constraints on the animal user. Ideally, such change should
      involve full ownership and buy-in from the affected animal user group. The range 
      of stakeholders involved in the animal-welfare debate includes industry and
      producer groups, science bodies, and animal-welfare non-governmental
      organizations and professional groups, including the veterinary and legal
      professions. The veterinary profession, in particular, is expected to play an
      animal-welfare leadership role, and we discuss expectation versus reality at both
      a national and an international level. This latter discussion includes specific
      reference to the role of the World Organisation for Animal Health (the OIE) as an
      intergovernmental organization representing 175 countries and details some of the
      major achievements since the OIE assumed its international animal-welfare
      standard-setting role in 2002. We also address the role of the veterinary
      profession at national, regional, and international levels.
FAU - Bayvel, A C David
AU  - Bayvel AC
AD  - Ministry of Agriculture and Forestry, Biosecurity New Zealand, Wellington, New
      Zealand. david.bayvel@maf.govt.nz
FAU - Cross, Nicki
AU  - Cross N
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - J Vet Med Educ
JT  - Journal of veterinary medical education
JID - 7610519
SB  - IM
MH  - Agriculture/legislation & jurisprudence/standards/trends
MH  - Animal Feed/standards
MH  - Animal Husbandry
MH  - Animal Rights/legislation & jurisprudence/standards
MH  - Animal Technicians
MH  - *Animal Welfare
MH  - Animals
MH  - Animals, Domestic
MH  - Decision Making
MH  - Education, Veterinary/standards
MH  - Europe
MH  - Humans
MH  - International Cooperation
MH  - New Zealand
MH  - *Public Policy
EDAT- 2010/04/10 06:00
MHDA- 2010/08/21 06:00
CRDT- 2010/04/10 06:00
PHST- 2010/04/10 06:00 [entrez]
PHST- 2010/04/10 06:00 [pubmed]
PHST- 2010/08/21 06:00 [medline]
AID - 37/1/3 [pii]
AID - 10.3138/jvme.37.1.3 [doi]
PST - ppublish
SO  - J Vet Med Educ. 2010 Spring;37(1):3-12. doi: 10.3138/jvme.37.1.3.


PMID- 20378281
OWN - NLM
STAT- MEDLINE
DCOM- 20101109
LR  - 20211020
IS  - 1879-0046 (Electronic)
IS  - 0376-8716 (Linking)
VI  - 110
IP  - 3
DP  - 2010 Aug 1
TI  - Failure to treat tobacco use in mental health and addiction treatment settings: a
      form of harm reduction?
PG  - 177-82
LID - 10.1016/j.drugalcdep.2010.03.002 [doi]
AB  - In mental health and addiction treatment settings, failure to treat tobacco
      dependence has been rationalized by some as a clinical approach to harm
      reduction. That is, tobacco use is viewed as a less harmful alternative to
      alcohol or illicit drug use and/or other self-harm behaviors. This paper examines
      the impact of providers' failure to treat tobacco use on patients' alcohol and
      illicit drug use and associated high-risk behaviors. The weight of the evidence
      in the literature indicates: (1) tobacco use is a leading cause of death in
      patients with psychiatric illness or addictive disorders; (2) tobacco use is
      associated with worsened substance abuse treatment outcomes, whereas treatment of
      tobacco dependence supports long-term sobriety; (3) tobacco use is associated
      with increased (not decreased) depressive symptoms and suicidal risk behavior;
      (4) tobacco use adversely impacts psychiatric treatment; (5) tobacco use is a
      lethal and ineffective long-term coping strategy for managing stress, and (6)
      treatment of tobacco use does not harm mental health recovery. Failure to treat
      tobacco dependence in mental health and addiction treatment settings is not
      consistent with a harm reduction model. In contrast, emerging evidence indicates 
      treatment of tobacco dependence may even improve addiction treatment and mental
      health outcomes. Providers in mental health and addiction treatment settings have
      an ethical duty to intervene on patients' tobacco use and provide available
      evidence-based treatments.
CI  - Copyright (c) 2010. Published by Elsevier Ireland Ltd.
FAU - Prochaska, Judith J
AU  - Prochaska JJ
AD  - University of California-San Francisco, 401 Parnassus Avenue, San Francisco, CA
      94143-0984, USA. JProchaska@ucsf.edu
LA  - eng
GR  - R01 MH083684-03/MH/NIMH NIH HHS/United States
GR  - R01 MH083684/MH/NIMH NIH HHS/United States
GR  - K23 DA018691-05/DA/NIDA NIH HHS/United States
GR  - P50 DA09253/DA/NIDA NIH HHS/United States
GR  - K23 DA018691/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20100407
PL  - Ireland
TA  - Drug Alcohol Depend
JT  - Drug and alcohol dependence
JID - 7513587
RN  - 0 (Alcohol Deterrents)
RN  - 0 (Illicit Drugs)
SB  - IM
MH  - Adaptation, Psychological
MH  - Alcohol Deterrents/therapeutic use
MH  - Alcohol Drinking/*prevention & control
MH  - Comorbidity
MH  - Depression/prevention & control/rehabilitation
MH  - *Harm Reduction
MH  - Humans
MH  - Illicit Drugs
MH  - Mental Disorders/prevention & control/*rehabilitation
MH  - Mental Health
MH  - *Mental Health Services
MH  - Risk Factors
MH  - Smoking Cessation
MH  - Stress, Psychological
MH  - Substance-Related Disorders/prevention & control/*rehabilitation
MH  - Suicide/prevention & control
MH  - Temperance
MH  - *Tobacco Use Disorder/therapy
PMC - PMC2916693
MID - NIHMS224315
EDAT- 2010/04/10 06:00
MHDA- 2010/11/10 06:00
CRDT- 2010/04/10 06:00
PHST- 2009/09/19 00:00 [received]
PHST- 2010/03/09 00:00 [revised]
PHST- 2010/03/09 00:00 [accepted]
PHST- 2010/04/10 06:00 [entrez]
PHST- 2010/04/10 06:00 [pubmed]
PHST- 2010/11/10 06:00 [medline]
AID - S0376-8716(10)00101-8 [pii]
AID - 10.1016/j.drugalcdep.2010.03.002 [doi]
PST - ppublish
SO  - Drug Alcohol Depend. 2010 Aug 1;110(3):177-82. doi:
      10.1016/j.drugalcdep.2010.03.002. Epub 2010 Apr 7.


PMID- 20378225
OWN - NLM
STAT- MEDLINE
DCOM- 20100714
LR  - 20220408
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 70
IP  - 12
DP  - 2010 Jun
TI  - Assessing the quality of democratic deliberation: a case study of public
      deliberation on the ethics of surrogate consent for research.
PG  - 1896-1903
LID - S0277-9536(10)00194-2 [pii]
LID - 10.1016/j.socscimed.2010.02.031 [doi]
AB  - "Deliberative democracy" is an increasingly popular method for soliciting public 
      input on health care policies. There are a number of ways of organizing
      deliberative democracy (DD) sessions, but they generally involve gathering a
      group of citizens, supplying them with information relevant to the policy in
      question, giving them time to interact with each other and with experts in the
      policy area, and collecting their informed and considered opinions. As the method
      has become more widely used, some have questioned the quality of the public input
      it generates. Although theorists of DD agree that "good" input - i.e., input that
      is the product of careful and thorough reflection - is an essential aspect of
      useful and effective deliberation, few have actually measured the quality of
      deliberative sessions. As part of a DD project organized to help guide policies
      on the morally complex question of allowing surrogate permission to enroll
      persons with dementia in medical research, we developed and tested measures of
      "quality of deliberation." After a brief discussion of the substantive results of
      our research - survey data from participants in the DD sessions and control
      groups showed a significant change in participants' attitudes toward surrogate
      consent - we examine the process by which this change occurred, describing and
      assessing the characteristics of our DD sessions. We use both quantitative and
      qualitative data from our DD sessions, conducted in southeastern Michigan, United
      States, to examine four dimensions of the quality of deliberation: 1) equal
      participation by all members of the session, 2) respect for the opinions of
      others, 3) a willingness to adopt a societal perspective on the issue in question
      (rather than a focus on what is best for participants as individuals), and 4)
      reasoned justification of one's positions. We demonstrate that DD can be reliably
      used to elicit opinions of the public and show how analysis of the quality of
      deliberations can offer insight into the ways opinions about ethical dilemmas are
      formed and changed.
CI  - Copyright 2010 Elsevier Ltd. All rights reserved.
FAU - De Vries, Raymond
AU  - De Vries R
AD  - University of Michigan, Bioethics Program, Ann Arbor, 300 North Ingalls Street,
      MI, USA. Electronic address: rdevries@umich.edu.
FAU - Stanczyk, Aimee
AU  - Stanczyk A
AD  - University of Michigan, Bioethics Program, Ann Arbor, 300 North Ingalls Street,
      MI, USA.
FAU - Wall, Ian F
AU  - Wall IF
AD  - University of Michigan, Bioethics Program, Ann Arbor, 300 North Ingalls Street,
      MI, USA.
FAU - Uhlmann, Rebecca
AU  - Uhlmann R
AD  - University of Michigan, Bioethics Program, Ann Arbor, 300 North Ingalls Street,
      MI, USA.
FAU - Damschroder, Laura J
AU  - Damschroder LJ
AD  - Ann Arbor VA Health Services Research and Development Center for Clinical
      Management Research, USA.
FAU - Kim, Scott Y
AU  - Kim SY
AD  - University of Michigan, Bioethics Program, Ann Arbor, 300 North Ingalls Street,
      MI, USA.
LA  - eng
GR  - R01 AG029550/AG/NIA NIH HHS/United States
GR  - R01 AG029550-03/AG/NIA NIH HHS/United States
GR  - R01-AG029550/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
DEP - 20100316
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Attitude to Health
MH  - *Community Participation
MH  - Dementia
MH  - *Democracy
MH  - *Ethics, Research
MH  - Female
MH  - Health Policy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Public Opinion
MH  - Qualitative Research
MH  - Third-Party Consent/*ethics
MH  - United States
PMC - PMC2866810
MID - NIHMS189737
EDAT- 2010/04/10 06:00
MHDA- 2010/07/16 06:00
CRDT- 2010/04/10 06:00
PHST- 2009/08/12 00:00 [received]
PHST- 2010/02/17 00:00 [revised]
PHST- 2010/02/22 00:00 [accepted]
PHST- 2010/04/10 06:00 [entrez]
PHST- 2010/04/10 06:00 [pubmed]
PHST- 2010/07/16 06:00 [medline]
AID - S0277-9536(10)00194-2 [pii]
AID - 10.1016/j.socscimed.2010.02.031 [doi]
PST - ppublish
SO  - Soc Sci Med. 2010 Jun;70(12):1896-1903. doi: 10.1016/j.socscimed.2010.02.031.
      Epub 2010 Mar 16.


PMID- 20377888
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20100520
LR  - 20220330
IS  - 1478-7547 (Electronic)
IS  - 1478-7547 (Linking)
VI  - 8
DP  - 2010 Apr 8
TI  - Combining multicriteria decision analysis, ethics and health technology
      assessment: applying the EVIDEM decision-making framework to growth hormone for
      Turner syndrome patients.
PG  - 4
LID - 10.1186/1478-7547-8-4 [doi]
AB  - OBJECTIVES: To test and further develop a healthcare policy and clinical decision
      support framework using growth hormone (GH) for Turner syndrome (TS) as a complex
      case study. METHODS: The EVIDEM framework was further developed to complement the
      multicriteria decision analysis (MCDA) Value Matrix, that includes 15
      quantifiable components of decision clustered in four domains (quality of
      evidence, disease, intervention and economics), with a qualitative tool including
      six ethical and health system-related components of decision. An extensive review
      of the literature was performed to develop a health technology assessment report 
      (HTA) tailored to each component of decision, and content was validated by
      experts. A panel of representative stakeholders then estimated the MCDA value of 
      GH for TS in Canada by assigning weights and scores to each MCDA component of
      decision and then considered the impact of non-quantifiable components of
      decision. RESULTS: Applying the framework revealed significant data gaps and the 
      importance of aligning research questions with data needs to truly inform
      decision. Panelists estimated the value of GH for TS at 41% of maximum value on
      the MCDA scale, with good agreement at the individual level (retest value 40%;
      ICC: 0.687) and large variation across panelists. Main contributors to this panel
      specific value were "Improvement of efficacy", "Disease severity" and "Quality of
      evidence". Ethical considerations on utility, efficiency and fairness as well as 
      potential misuse of GH had mixed effects on the perceived value of the treatment.
      CONCLUSIONS: This framework is proposed as a pragmatic step beyond the current
      cost-effectiveness model, combining HTA, MCDA, values and ethics. It supports
      systematic consideration of all components of decision and available evidence for
      greater transparency. Further testing and validation is needed to build up MCDA
      approaches combined with pragmatic HTA in healthcare decision-making.
FAU - Goetghebeur, Mireille M
AU  - Goetghebeur MM
AD  - BioMedCom Consultants inc, Dorval, Quebec, Canada.
      mireille_goetghebeur@biomedcom.org
FAU - Wagner, Monika
AU  - Wagner M
FAU - Khoury, Hanane
AU  - Khoury H
FAU - Rindress, Donna
AU  - Rindress D
FAU - Gregoire, Jean-Pierre
AU  - Gregoire JP
FAU - Deal, Cheri
AU  - Deal C
LA  - eng
PT  - Journal Article
DEP - 20100408
PL  - England
TA  - Cost Eff Resour Alloc
JT  - Cost effectiveness and resource allocation : C/E
JID - 101170476
PMC - PMC2856527
EDAT- 2010/04/10 06:00
MHDA- 2010/04/10 06:01
CRDT- 2010/04/10 06:00
PHST- 2009/11/04 00:00 [received]
PHST- 2010/04/08 00:00 [accepted]
PHST- 2010/04/10 06:00 [entrez]
PHST- 2010/04/10 06:00 [pubmed]
PHST- 2010/04/10 06:01 [medline]
AID - 1478-7547-8-4 [pii]
AID - 10.1186/1478-7547-8-4 [doi]
PST - epublish
SO  - Cost Eff Resour Alloc. 2010 Apr 8;8:4. doi: 10.1186/1478-7547-8-4.


PMID- 20377572
OWN - NLM
STAT- MEDLINE
DCOM- 20120518
LR  - 20120119
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 26
IP  - 2
DP  - 2012 Feb
TI  - Two stalemates in the philosophical debate about abortion and why they cannot be 
      resolved using analogical arguments.
PG  - 84-92
LID - 10.1111/j.1467-8519.2010.01815.x [doi]
AB  - Philosophical debate about the ethics of abortion has reached stalemate on two
      key issues. First, the claim that foetuses have moral standing that entitles them
      to protections for their lives has been neither convincingly established nor
      refuted. Second, the question of a pregnant woman's obligation to allow the
      gestating foetus the use of her body has not been resolved. Both issues are
      deadlocked because philosophers addressing them invariably rely on intuitions and
      analogies, and such arguments have weaknesses that make them unfit for resolving 
      the abortion issue. Analogical arguments work by building a kind of consensus,
      and such a consensus is virtually unimaginable because (1) intuitions are
      revisable, and in the abortion debate there is great motive to revise them, (2)
      one's position on abortion influences judgments about other issues, making it
      difficult to leverage intuitions about other ethical questions into changing
      peoples' minds about abortion, and (3) the extent of shared values in the
      abortion debate is overstated. Arguments by analogy rely on an assumption of the 
      commensurability of moral worldviews. But the abortion debate is currently
      unfolding in a context of genuinely incommensurable moral worldviews. The article
      ends by arguing that the default position must be to permit abortion as a
      consequence of the freedom of conscience protected in liberal societies.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Kaposy, Chris
AU  - Kaposy C
AD  - Memorial University of Newfoundland. christopher.kaposy@med.mun.ca
LA  - eng
PT  - Journal Article
DEP - 20100405
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Abortion, Induced/*ethics
MH  - *Bioethical Issues
MH  - Female
MH  - Fetus
MH  - Humans
MH  - Morals
MH  - Personhood
MH  - *Philosophy
MH  - Pregnancy
EDAT- 2010/04/10 06:00
MHDA- 2012/05/19 06:00
CRDT- 2010/04/10 06:00
PHST- 2010/04/10 06:00 [entrez]
PHST- 2010/04/10 06:00 [pubmed]
PHST- 2012/05/19 06:00 [medline]
AID - BIOT1815 [pii]
AID - 10.1111/j.1467-8519.2010.01815.x [doi]
PST - ppublish
SO  - Bioethics. 2012 Feb;26(2):84-92. doi: 10.1111/j.1467-8519.2010.01815.x. Epub 2010
      Apr 5.


PMID- 20377302
OWN - NLM
STAT- MEDLINE
DCOM- 20100518
LR  - 20190518
IS  - 0261-1929 (Print)
IS  - 0261-1929 (Linking)
VI  - 38
IP  - 1
DP  - 2010 Mar
TI  - An estimation of the extent of animal use in research in Brazil, as determined by
      bibliographic sampling from journals published in the State of Parana.
PG  - 29-37
AB  - Animal use in research is an issue of increasing ethical concern. The objective
      of this work was to investigate animal use in research described in the papers
      appearing in 18 journals published in the State of Parana in 2006. The fields
      used in the bibliographic sampling were: agrarian science, biological science,
      biological and health science, environmental science, food technology, and health
      science. Of the 865 papers analysed, 41% involved the use of animals - a total of
      3,497,653 animals, of which 216,223 were vertebrates. Procedures which were
      classified as A or B for degree of invasiveness were involved in 67% of the
      papers; 571 fish were employed in procedures classified as E. Only 11% of the
      journals required certificates from Animal Use Ethics Committees. These results
      suggest that Brazil is important in the context of worldwide animal use for
      research, in terms of both the total numbers of animals and the numbers of
      vertebrates used. Bibliographical sampling is a useful method for estimating the 
      extent of animal use in experiments in Brazil. However, there are limitations to 
      this approach, resulting from the geographical distribution of the authors, the
      existence of papers presenting insufficient information, and the exclusive
      inclusion of animal experimentation that actually reaches publication. Thus, the 
      introduction of a formal system to record and control laboratory animal use in
      Brazil, is urgently required.
CI  - 2010 FRAME.
FAU - Silla, Vanessa Carli Bones
AU  - Silla VC
AD  - Animal Welfare Laboratory, Federal University of Parana (UFPR), Curitiba, PR,
      Brazil.
FAU - de Oliveira Sans, Elaine Cristina
AU  - de Oliveira Sans EC
FAU - Molento, Carla Forte Maiolino
AU  - Molento CF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Altern Lab Anim
JT  - Alternatives to laboratory animals : ATLA
JID - 8110074
SB  - IM
MH  - Animal Experimentation/*statistics & numerical data
MH  - Animal Welfare
MH  - Animals
MH  - Bibliography, Descriptive
MH  - Brazil
EDAT- 2010/04/10 06:00
MHDA- 2010/05/19 06:00
CRDT- 2010/04/10 06:00
PHST- 2010/04/10 06:00 [entrez]
PHST- 2010/04/10 06:00 [pubmed]
PHST- 2010/05/19 06:00 [medline]
AID - 10.1177/026119291003800110 [doi]
PST - ppublish
SO  - Altern Lab Anim. 2010 Mar;38(1):29-37. doi: 10.1177/026119291003800110.


PMID- 20376978
OWN - NLM
STAT- MEDLINE
DCOM- 20100427
LR  - 20100408
IS  - 1603-6824 (Electronic)
IS  - 0041-5782 (Linking)
VI  - 172
IP  - 10
DP  - 2010 Mar 8
TI  - [Prenatal diagnosis and ethics].
PG  - 814; author reply 814
FAU - Teglgaard, Thomas
AU  - Teglgaard T
LA  - dan
PT  - Letter
TT  - Fosterdiagnostik og etik.
PL  - Denmark
TA  - Ugeskr Laeger
JT  - Ugeskrift for laeger
JID - 0141730
SB  - IM
MH  - Female
MH  - Humans
MH  - Pregnancy
MH  - Prenatal Diagnosis/*ethics
MH  - *Rape
MH  - Religion
MH  - *Value of Life
EDAT- 2010/04/10 06:00
MHDA- 2010/04/28 06:00
CRDT- 2010/04/10 06:00
PHST- 2010/04/10 06:00 [entrez]
PHST- 2010/04/10 06:00 [pubmed]
PHST- 2010/04/28 06:00 [medline]
PST - ppublish
SO  - Ugeskr Laeger. 2010 Mar 8;172(10):814; author reply 814.


PMID- 20376768
OWN - NLM
STAT- MEDLINE
DCOM- 20100915
LR  - 20220318
IS  - 1438-8790 (Electronic)
IS  - 0934-8387 (Linking)
VI  - 64
IP  - 4
DP  - 2010 Apr
TI  - [Non-invasive and invasive mechanical ventilation for treatment of chronic
      respiratory failure. S2-Guidelines published by the German Medical Association of
      Pneumology and Ventilatory Support].
PG  - 207-40
LID - 10.1055/s-0029-1243978 [doi]
AB  - The field of mechanical ventilation is highly important in pulmonary medicine.
      The German Medical Association of Pneumology and Ventilatory Support ["Deutsche
      Gesellschaft fur Pneumologie und Beatmungsmedizin e. V. (DGP)"] therefore has
      formulated these guidelines for home mechanical non-invasive and invasive
      ventilation. Non-invasive home mechanical ventilation can be administered using
      various facial masks; invasive home mechanical ventilation is performed via a
      tracheostomy. Home mechanical ventilation is widely and increasingly accepted as 
      a treatment option for chronic ventilatory failure which most often occurs in
      COPD, restrictive lung diseases, obesity-hypoventilation syndrome and
      neuromuscular disorders. Essential for the initiation of home mechanical
      ventilation are the presence of symptoms of ventilatory failure and the detection
      of hypoventilation, most importantly hypercapnia. These guidelines comprise
      general indication criteria along with disease-specific criteria summarised by
      treatment algorithms. In addition, the management of bronchial secretions and
      care of paediatric patients are addressed. Home mechanical ventilation must be
      organised around a specialised respiratory care centre with expertise in patient 
      selection, the initiation and the control of home mechanical ventilation. In this
      regard, the guidelines provide detailed information about technical requirements 
      (equipment), control and settings of mechanical ventilation as well as
      organisation of patient care. A key requirement for home mechanical ventilation
      is the qualification of specialised home-care services, which is addressed in
      detail. Independent living and the quality of respiratory care are of highest
      priority in patients receiving home mechanical ventilation, since home mechanical
      ventilation can interfere with the integrity of a patient and often marks a
      life-sustaining therapy. Home mechanical ventilation has been shown to improve
      health-related quality of life of patients with chronic ventilatory failure.
      Long-term survival is improved in most patient groups, even though the long-term 
      prognosis is often severely limited. For this reason, ethical issues regarding
      patient education, communication with ventilated patients at the end of life,
      living will, testament and medical care during the dying process are discussed.
CI  - Georg Thieme Verlag KG Stuttgart . New York.
FAU - Windisch, W
AU  - Windisch W
AD  - Universitatsklinik Freiburg, Abteilung Pneumologie, Freiburg.
      wolfram.windisch@uniklinik-freiburg.de
FAU - Brambring, J
AU  - Brambring J
FAU - Budweiser, S
AU  - Budweiser S
FAU - Dellweg, D
AU  - Dellweg D
FAU - Geiseler, J
AU  - Geiseler J
FAU - Gerhard, F
AU  - Gerhard F
FAU - Kohnlein, T
AU  - Kohnlein T
FAU - Mellies, U
AU  - Mellies U
FAU - Schonhofer, B
AU  - Schonhofer B
FAU - Schucher, B
AU  - Schucher B
FAU - Siemon, K
AU  - Siemon K
FAU - Walterspacher, S
AU  - Walterspacher S
FAU - Winterholler, M
AU  - Winterholler M
FAU - Sitter, H
AU  - Sitter H
CN  - Projektgruppe Nichtinvasive und invasive Beatmung als Therapie der chronischen
      respiratorischen Insuffizienz
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Practice Guideline
PT  - Review
TT  - Nichtinvasive und invasive Beatmung als Therapie der chronischen respiratorischen
      Insuffizienz. S2-Leitlinie herausgegeben von der Deutschen Gesellschaft fur
      Pneumologie und Beatmungsmedizin e. V.
DEP - 20100407
PL  - Germany
TA  - Pneumologie
JT  - Pneumologie (Stuttgart, Germany)
JID - 8906641
SB  - IM
MH  - Continuous Positive Airway Pressure/instrumentation/*methods/psychology
MH  - Equipment Design
MH  - Evidence-Based Medicine
MH  - Germany
MH  - *Home Care Services, Hospital-Based
MH  - Humans
MH  - Quality of Life/psychology
MH  - Respiration, Artificial/instrumentation/*methods/psychology
MH  - Respiratory Insufficiency/etiology/psychology/*therapy
MH  - Societies, Medical
MH  - Tracheostomy/instrumentation/*methods/psychology
RF  - 339
EDAT- 2010/04/09 06:00
MHDA- 2010/09/16 06:00
CRDT- 2010/04/09 06:00
PHST- 2010/04/09 06:00 [entrez]
PHST- 2010/04/09 06:00 [pubmed]
PHST- 2010/09/16 06:00 [medline]
AID - 10.1055/s-0029-1243978 [doi]
PST - ppublish
SO  - Pneumologie. 2010 Apr;64(4):207-40. doi: 10.1055/s-0029-1243978. Epub 2010 Apr 7.


PMID- 20376706
OWN - NLM
STAT- MEDLINE
DCOM- 20101126
LR  - 20211028
IS  - 1543-706X (Electronic)
IS  - 1071-2690 (Linking)
VI  - 46
IP  - 7
DP  - 2010 Jul
TI  - Expression of stemness markers in mouse parthenogenetic-diploid blastocysts is
      influenced by slight variation of activation protocol adopted.
PG  - 619-23
LID - 10.1007/s11626-010-9312-4 [doi]
AB  - The importance of obtaining stem cells through alternative methods has increased 
      progressively in the recent years due to the potential role that embryonic stem
      (ES) cells play in the field of regenerative medicine. In this regard, generation
      of parthenogenetic blastocysts allows the production of ethic-free ES cells
      without the need to manipulate normal embryos. Our work was aimed at clarifying
      whether variations in the method adopted to generate diploid parthenogenetic
      blastocysts could determine differences in the quality of blastocysts produced.
      In vitro development of mouse oocytes activated with three protocols, using Sr2+ 
      and cytochalasin for different time, was compared with that of in vivo fertilized
      embryos. We have evaluated the efficiency of blastocyst formation and analysed
      the expression pattern of the stemness markers OCT4, CDX2, and NANOG. Our results
      indicate that the yield of diploid parthenogenotes and the segregation of the
      stemness marker OCT4 in the developing blastocyst are influenced by the
      parthenogenetic protocol adopted. Particularly, even if all methods tested
      allowed the production of blastocysts in vitro, the correct segregation of OCT4
      occurred only in blastocysts developed from oocytes concomitantly treated for 4 h
      with Sr2+ and cytochalasin D. Our results indicate that the protocol employed to 
      develop parthenogenetic blastocysts in vitro affects the quality of cells in the 
      inner cell mass.
FAU - Bianchi, Enrica
AU  - Bianchi E
AD  - Department of Public Health and Cell Biology, Section of Anatomy, University of
      Rome "Tor Vergata", Via Montpellier 1, 00133 Rome, Italy.
FAU - Geremia, Raffaele
AU  - Geremia R
FAU - Sette, Claudio
AU  - Sette C
LA  - eng
GR  - GGP09154/TI_/Telethon/Italy
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100408
PL  - Germany
TA  - In Vitro Cell Dev Biol Anim
JT  - In vitro cellular & developmental biology. Animal
JID - 9418515
RN  - 0 (Biomarkers)
RN  - 0 (Octamer Transcription Factor-3)
RN  - 0 (Pou5f1 protein, mouse)
SB  - IM
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Blastocyst/cytology/*metabolism
MH  - *Diploidy
MH  - Embryonic Development
MH  - Fertilization
MH  - Mice
MH  - Octamer Transcription Factor-3/metabolism
MH  - *Parthenogenesis
MH  - Research Embryo Creation/*methods
MH  - Stem Cells/*metabolism
EDAT- 2010/04/09 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/04/09 06:00
PHST- 2009/10/22 00:00 [received]
PHST- 2010/03/11 00:00 [accepted]
PHST- 2010/04/09 06:00 [entrez]
PHST- 2010/04/09 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1007/s11626-010-9312-4 [doi]
PST - ppublish
SO  - In Vitro Cell Dev Biol Anim. 2010 Jul;46(7):619-23. doi:
      10.1007/s11626-010-9312-4. Epub 2010 Apr 8.


PMID- 20376609
OWN - NLM
STAT- MEDLINE
DCOM- 20100916
LR  - 20211020
IS  - 1432-2129 (Electronic)
IS  - 0932-433X (Linking)
VI  - 24
IP  - 2
DP  - 2010 Apr
TI  - [A wish to hasten death : what is behind it].
PG  - 177-89
LID - 10.1007/s00482-010-0891-5 [doi]
AB  - "There's nothing more to do, so let's come to an end, Doc!" A request for
      euthanasia or physician-assisted suicide is a dramatic expression of patients'
      suffering and causes difficulties for staff members to react to these questions. 
      Great efforts have been made in the last two centuries to gain a deeper
      understanding of the wish for hastened death of terminally ill patients and to
      develop conclusions for the management of these situations. This article presents
      differences in international legislation on euthanasia and summarises the ethical
      background. The current results from the literature according to motivations for 
      the wish for hastened death, communicative functions of the request, attitudes
      and practices of physicians and their willingness to accompany the patient in
      euthanasia as well as practical implications for clinical practice are discussed.
FAU - Stiel, S
AU  - Stiel S
AD  - Klinik fur Palliativmedizin, Universitatsklinikum der RWTH Aachen, Pauwelsstr.
      30, 52074, Aachen, Deutschland. sstiel@ukaachen.de
FAU - Elsner, F
AU  - Elsner F
FAU - Pestinger, M
AU  - Pestinger M
FAU - Radbruch, L
AU  - Radbruch L
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Wunsch nach vorzeitigem Lebensende : Was steht dahinter?
PL  - Germany
TA  - Schmerz
JT  - Schmerz (Berlin, Germany)
JID - 8906258
SB  - IM
MH  - Anxiety Disorders/diagnosis/psychology
MH  - Attitude of Health Personnel
MH  - Communication
MH  - Cross-Cultural Comparison
MH  - Depressive Disorder/diagnosis/psychology
MH  - Ethics, Medical
MH  - Euthanasia/ethics/legislation & jurisprudence/*psychology
MH  - Germany
MH  - Humans
MH  - Medical Futility/ethics/legislation & jurisprudence/*psychology
MH  - *Motivation
MH  - Personal Autonomy
MH  - Physician-Patient Relations
MH  - Sick Role
MH  - Suicide, Assisted/ethics/legislation & jurisprudence/*psychology
MH  - Surveys and Questionnaires
MH  - Terminal Care/ethics/legislation & jurisprudence/*psychology
RF  - 50
EDAT- 2010/04/09 06:00
MHDA- 2010/09/18 06:00
CRDT- 2010/04/09 06:00
PHST- 2010/04/09 06:00 [entrez]
PHST- 2010/04/09 06:00 [pubmed]
PHST- 2010/09/18 06:00 [medline]
AID - 10.1007/s00482-010-0891-5 [doi]
PST - ppublish
SO  - Schmerz. 2010 Apr;24(2):177-89. doi: 10.1007/s00482-010-0891-5.


PMID- 20375881
OWN - NLM
STAT- MEDLINE
DCOM- 20100803
LR  - 20100504
IS  - 1473-6500 (Electronic)
IS  - 0952-7907 (Linking)
VI  - 23
IP  - 3
DP  - 2010 Jun
TI  - Anesthetic optimization for nonheartbeating donors.
PG  - 406-10
LID - 10.1097/ACO.0b013e3283395352 [doi]
AB  - PURPOSE OF REVIEW: One of the newest strategies to enlarge the pool of organ
      donors is to consider the category of donors after cardiac death rather than only
      after brain death. Prompt and accurate identification of potential donors and
      appropriate care is necessary to optimize the management of nonheartbeating
      donors. RECENT FINDINGS: Organ procurement derived from donors after cardiac
      death is becoming a part of the policy of major transplantation hospitals,
      forcing them to consider the practical interventions and ethical implications
      regarding this practice. Typical donors are patients affected by irreversible
      brain injuries, high spinal cord injury and end-stage musculoskeletal diseases.
      To start the process the following three conditions must be met. Withdrawal of
      life-sustaining therapies must be considered independently from transplantation. 
      Withdrawal of life support requires a careful titration of the drugs controlling 
      pain, anxiety and discomfort. Organ harvesting has to be initiated after at least
      2-5 min of confirmed cardiac death. SUMMARY: In order to increase the number of
      organs available for transplantation, donation from nonheartbeating donors has
      been recently proposed. Identification of the key aspects of the donation after
      cardiac death should be fully achieved by the team involved in the
      transplantation program. Development of hospital policies and identification of
      receivers who are most likely to benefit from this strategy require further
      studies to assess long-term outcome and to identify ethical aspects concerning
      different religious and cultural backgrounds.
FAU - Fanelli, Vito
AU  - Fanelli V
AD  - Dipartimento di Anestesiologia e Rianimazione, Universita di Torino, Ospedale S. 
      Giovanni Battista-Molinette, Torino, Italy.
FAU - Mascia, Luciana
AU  - Mascia L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Curr Opin Anaesthesiol
JT  - Current opinion in anaesthesiology
JID - 8813436
SB  - IM
MH  - Anesthesia/*methods
MH  - *Death
MH  - Humans
MH  - *Tissue Donors
MH  - Tissue and Organ Procurement/ethics/methods
RF  - 37
EDAT- 2010/04/09 06:00
MHDA- 2010/08/04 06:00
CRDT- 2010/04/09 06:00
PHST- 2010/04/09 06:00 [entrez]
PHST- 2010/04/09 06:00 [pubmed]
PHST- 2010/08/04 06:00 [medline]
AID - 10.1097/ACO.0b013e3283395352 [doi]
PST - ppublish
SO  - Curr Opin Anaesthesiol. 2010 Jun;23(3):406-10. doi: 10.1097/ACO.0b013e3283395352.


PMID- 20374785
OWN - NLM
STAT- MEDLINE
DCOM- 20100519
LR  - 20181201
IS  - 1873-4138 (Electronic)
IS  - 0309-1740 (Linking)
VI  - 84
IP  - 2
DP  - 2010 Feb
TI  - Manufacturing technology in the Danish pig slaughter industry.
PG  - 271-5
LID - 10.1016/j.meatsci.2009.03.012 [doi]
AB  - The Danish pig meat industry is very export oriented. Ninety per cent of the
      production of the big cooperative slaughterhouses is exported to more than 100
      countries all over the world. This poses a requirement for the industry to be
      globally competitive in the sense of quality, product safety and--of
      course--price. A big challenge for the industry is therefore to maintain
      sufficient low unit costs in spite of the high factor costs of Denmark. In
      particular the high labour costs must be accompanied by correspondingly high
      labour productivity. And, it should be emphasized, this high labour productivity 
      must be achieved without compromising the concern for good working conditions of 
      the employees in the manufacturing. Technology is one of the means to achieve
      this combination of good working conditions and high labour productivity. One of 
      the most important benefits from automation is the improved working environment. 
      Pig slaughtering, cutting and boning is traditionally very labour intensive and
      requires hard and repetitive work. For many people a job in a slaughterhouse is
      therefore not their first choice. This situation can be changed by automation,
      which will not only reduce arduous and repetitive work but in addition will
      introduce more motivating jobs in terms of planning, supervision and control of
      the new technology. Automation will also improve the hygiene and thereby the food
      safety. This applies in particular to the clean slaughter line where cross
      contamination between carcasses is reduced because of less manual handling and
      because the tools in the machines can be sterilised more effectively between each
      carcass. Automated processes are more accurate and repeatable than manual work.
      For some processes, in particular in cutting and boning, this will enhance the
      product yield. New technology can also improve the animal welfare. The
      group-stunning system and mechanised lairage systems are examples of that.
      Improved animal welfare has an ethical value in itself and also a value in terms 
      of the enhanced meat quality resulting from the more considerate treatment of the
      animals.
FAU - Hinrichsen, Lars
AU  - Hinrichsen L
AD  - Danish Meat Research Institute, Maglegaardsvej 2, DK-4000 Roskilde, Denmark.
      lhi@danishmeat.dk
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20090407
PL  - England
TA  - Meat Sci
JT  - Meat science
JID - 101160862
SB  - IM
MH  - *Abattoirs/economics/standards
MH  - Animal Welfare
MH  - Animals
MH  - *Automation
MH  - Commerce/economics/standards
MH  - Consumer Product Safety
MH  - Costs and Cost Analysis
MH  - Denmark
MH  - Food Handling/*methods
MH  - Hygiene
MH  - Meat/*standards
MH  - Swine
MH  - Workforce
RF  - 7
EDAT- 2010/04/09 06:00
MHDA- 2010/05/21 06:00
CRDT- 2010/04/09 06:00
PHST- 2009/03/18 00:00 [received]
PHST- 2009/03/31 00:00 [accepted]
PHST- 2010/04/09 06:00 [entrez]
PHST- 2010/04/09 06:00 [pubmed]
PHST- 2010/05/21 06:00 [medline]
AID - S0309-1740(09)00090-4 [pii]
AID - 10.1016/j.meatsci.2009.03.012 [doi]
PST - ppublish
SO  - Meat Sci. 2010 Feb;84(2):271-5. doi: 10.1016/j.meatsci.2009.03.012. Epub 2009 Apr
      7.


PMID- 20374187
OWN - NLM
STAT- MEDLINE
DCOM- 20100702
LR  - 20211020
IS  - 1525-6006 (Electronic)
IS  - 1064-1963 (Linking)
VI  - 32
IP  - 2
DP  - 2010 Jan
TI  - Clinical and pharmacotherapeutic relevance of the double-chain domain of the
      angiotensin II type 1 receptor blocker olmesartan.
PG  - 129-36
LID - 10.3109/10641960903254430 [doi]
AB  - We previously reported that the angiotensin II type 1 (AT(1)) receptor blocker
      (ARB) olmesartan has two important interactions to evoke inverse agonism (IA). We
      refer to these interactions as the "double-chain domain (DCD)." Since the
      clinical pharmacotherapeutic relevance of olmesartan is still unclear, we
      examined these effects in rats and humans. We analyzed the effects at an advanced
      stage of renal insufficiency in Dahl salt-sensitive hypertensive rats (Study 1). 
      Rats were fed a high-salt diet from age 9 weeks and arbitrarily assigned to three
      treatment regimens at age 16 to 21 weeks: olmesartan (2 mg/kg/day) with DCD, a
      compound related to olmesartan without DCD (6 mg/kg/day, R-239470) or placebo. We
      also compared the depressor effects of olmesartan to those of other ARBs in
      patients with essential hypertension (Study 2). Thirty essential hypertensive
      outpatients who had been receiving ARBs other than olmesartan were recruited for 
      this study. Our protocol was approved by the hospital ethics committee and
      informed consent was obtained from all patients 12 weeks prior to switching from 
      ARBs other than olmesartan to olmesartan. In Study 1, olmesartan induced a more
      prominent suppression of the ratio of urinary protein excretion to creatinine at 
      age 21 weeks without lowering blood pressure among the three groups. In Study 2, 
      the depressor effect of olmesartan was significantly stronger than those of other
      ARBs, which do not contain the DCD. These additive effects by olmesartan may be
      due to DCD.
FAU - Kiya, Yoshihiro
AU  - Kiya Y
AD  - Department of Cardiology, Fukuoka University School of Medicine, Jonan-Ku,
      Fukuoka, Japan.
FAU - Miura, Shin-Ichiro
AU  - Miura S
FAU - Fujino, Masahiro
AU  - Fujino M
FAU - Imaizumi, Satoshi
AU  - Imaizumi S
FAU - Karnik, Sadashiva S
AU  - Karnik SS
FAU - Saku, Keijiro
AU  - Saku K
LA  - eng
GR  - R01 HL057470/HL/NHLBI NIH HHS/United States
GR  - R01 HL064845/HL/NHLBI NIH HHS/United States
GR  - R01 HL083243/HL/NHLBI NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PL  - England
TA  - Clin Exp Hypertens
JT  - Clinical and experimental hypertension (New York, N.Y. : 1993)
JID - 9305929
RN  - 0 (Angiotensin II Type 1 Receptor Blockers)
RN  - 0 (Imidazoles)
RN  - 0 (Receptor, Angiotensin, Type 1)
RN  - 0 (Tetrazoles)
RN  - 8W1IQP3U10 (olmesartan)
SB  - IM
MH  - Aged
MH  - Angiotensin II Type 1 Receptor Blockers/*chemistry/*pharmacology
MH  - Animals
MH  - Binding Sites
MH  - Blood Pressure/drug effects
MH  - Female
MH  - Heart Rate/drug effects
MH  - Humans
MH  - Hydrogen Bonding
MH  - Hypertension/drug therapy/physiopathology
MH  - Imidazoles/*chemistry/*pharmacology
MH  - Male
MH  - Middle Aged
MH  - Models, Molecular
MH  - Rats
MH  - Rats, Inbred Dahl
MH  - Receptor, Angiotensin, Type 1/chemistry/*drug effects
MH  - Renal Insufficiency, Chronic/prevention & control
MH  - Static Electricity
MH  - Tetrazoles/*chemistry/*pharmacology
PMC - PMC3891519
MID - NIHMS541645
EDAT- 2010/04/09 06:00
MHDA- 2010/07/03 06:00
CRDT- 2010/04/09 06:00
PHST- 2010/04/09 06:00 [entrez]
PHST- 2010/04/09 06:00 [pubmed]
PHST- 2010/07/03 06:00 [medline]
AID - 10.3109/10641960903254430 [doi]
PST - ppublish
SO  - Clin Exp Hypertens. 2010 Jan;32(2):129-36. doi: 10.3109/10641960903254430.


PMID- 20373833
OWN - NLM
STAT- MEDLINE
DCOM- 20100526
LR  - 20190917
IS  - 1130-0108 (Print)
IS  - 1130-0108 (Linking)
VI  - 102
IP  - 3
DP  - 2010 Mar
TI  - Gastrojejunal anastomosis stricture after laparoscopic gastric bypass. Our
      experience with 62 patients.
PG  - 187-92
AB  - OBJECTIVE: Gastrojejunal stricture (GYS), not only is a common complication after
      laparoscopic gastric bypass (LGBP), but its frequency is about 15% according to
      bibliography. Our aim is to present our experience after 62 LGBP. PATIENTS AND
      METHOD: From January 2004 to September-2006, we performed 62 consecutive
      laparoscopic gastric bypass (Wittgrove's technique). The gastrojejunal
      anastomosis is performed with auto suture material type CEAA No 21
      termino-lateral (ILS, Ethicon). In 4 cases (6.45%) was converted to laparotomy,
      perform the anastomosis in the same way. Monitoring has a range of 3-35 months,
      conducted in 61 patients because one patient died of pulmonary thromboembolism in
      the immediate postoperative period after reoperation, after two weeks of gastric 
      bypass, by necrosis of a small fragment of the remnant gastric. In all patients
      with persistent feeding intolerance were performed barium transit and/or
      gastroscopy. When gastrojejunal stricture showed proceeded to endoscopic
      pneumatic dilation (recommending dilate the anastomosis to a maximum 1.5 cm).
      RESULTS: Five cases (8.1%) developed a gastrojejunal stricture, in 4 of these
      cases the initial diagnosis was made by barium transit and in 1 case by
      endoscopy. Two patients had a history of digestive bleeding that required
      endoscopic sclerosis of the bleeding lesion (circumferentially sclerosis within
      48 hours of surgery and sclerosis of bleeding points). All cases were resolved by
      endoscopic dilatation. At follow-up has not been detected re-stricture.
      CONCLUSION: Clinically, gastrojejunal stricture results in a progressive oral
      intolerance, revealing stenosis between 1 and 3 months postoperatively. The
      situations of sclerosis of the bleeding lesions favor, especially in cases of
      extensive sclerosis. In cases of suspected barium transit offers us a high
      diagnostic yield. Endoscopic dilatation resolved, so far, all cases.
FAU - Campillo-Soto, Alvaro
AU  - Campillo-Soto A
AD  - Service of General Surgery, Hospital General Universitario J. M. Morales
      Meseguer, Murcia, Spain. alvaroalcubo@yahoo.es
FAU - Torralba-Martinez, J A
AU  - Torralba-Martinez JA
FAU - Martin-Lorenzo, J G
AU  - Martin-Lorenzo JG
FAU - Liron-Ruiz, R
AU  - Liron-Ruiz R
FAU - Bento-Gerard, M
AU  - Bento-Gerard M
FAU - Perez-Cuadrado, E
AU  - Perez-Cuadrado E
FAU - Aguayo-Albasini, J L
AU  - Aguayo-Albasini JL
LA  - eng
LA  - spa
PT  - Journal Article
PL  - Spain
TA  - Rev Esp Enferm Dig
JT  - Revista espanola de enfermedades digestivas : organo oficial de la Sociedad
      Espanola de Patologia Digestiva
JID - 9007566
SB  - IM
CIN - Rev Esp Enferm Dig. 2010 Mar;102(3):151-8. PMID: 20373829
MH  - Adult
MH  - Catheterization
MH  - Constriction, Pathologic/etiology/therapy
MH  - Female
MH  - Gastric Bypass/*adverse effects/methods
MH  - Humans
MH  - Laparoscopy
MH  - Male
MH  - Middle Aged
MH  - Obesity, Morbid/*surgery
MH  - Postoperative Complications/diagnosis/therapy
EDAT- 2010/04/09 06:00
MHDA- 2010/05/27 06:00
CRDT- 2010/04/09 06:00
PHST- 2010/04/09 06:00 [entrez]
PHST- 2010/04/09 06:00 [pubmed]
PHST- 2010/05/27 06:00 [medline]
AID - 10.4321/s1130-01082010000300005 [doi]
PST - ppublish
SO  - Rev Esp Enferm Dig. 2010 Mar;102(3):187-92. doi: 10.4321/s1130-01082010000300005.


PMID- 20373733
OWN - NLM
STAT- MEDLINE
DCOM- 20100505
LR  - 20211020
IS  - 0193-7758 (Print)
IS  - 0193-7758 (Linking)
VI  - 32
IP  - 2
DP  - 2010 Mar-Apr
TI  - Genetic research with stored biological materials: ethics and practice.
PG  - 7-18
FAU - Wolf, Leslie E
AU  - Wolf LE
AD  - Georgia State University College of Law, Atlanta, GA, USA.
FAU - Bouley, Timothy A
AU  - Bouley TA
FAU - McCulloch, Charles E
AU  - McCulloch CE
LA  - eng
GR  - R01 CA117868/CA/NCI NIH HHS/United States
GR  - R01 CA117868-01/CA/NCI NIH HHS/United States
GR  - R01 CA117868-02/CA/NCI NIH HHS/United States
GR  - R01CA117868/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - IRB
JT  - IRB
JID - 7906878
SB  - IM
MH  - Adult
MH  - Biological Specimen Banks/*ethics
MH  - Child
MH  - Confidentiality
MH  - Disclosure
MH  - Ethics Committees, Research
MH  - Genetic Research/*ethics
MH  - *Guideline Adherence
MH  - Humans
MH  - Informed Consent
MH  - Ownership
MH  - Tissue Donors
MH  - Tissue and Organ Procurement/*ethics
MH  - United States
PMC - PMC3052851
MID - NIHMS276728
EDAT- 2010/04/09 06:00
MHDA- 2010/05/06 06:00
CRDT- 2010/04/09 06:00
PHST- 2010/04/09 06:00 [entrez]
PHST- 2010/04/09 06:00 [pubmed]
PHST- 2010/05/06 06:00 [medline]
PST - ppublish
SO  - IRB. 2010 Mar-Apr;32(2):7-18.


PMID- 20373702
OWN - NLM
STAT- MEDLINE
DCOM- 20100514
LR  - 20100408
IS  - 1660-9379 (Print)
IS  - 1660-9379 (Linking)
VI  - 6
IP  - 239
DP  - 2010 Mar 10
TI  - [Apropos of the contribution of science and ethics to a less "deregulated"
      world].
PG  - 532-3
FAU - Martin, Jean
AU  - Martin J
AD  - Ancien medecin cantonal vaudois, membre de la CNE, La Ruelle 6, 1026 Echallens.
      jean.martin@urbanet.ch
LA  - fre
PT  - Journal Article
TT  - A propos de la contribution de la science et de l'ethique a un monde moins
      "deregle".
PL  - Switzerland
TA  - Rev Med Suisse
JT  - Revue medicale suisse
JID - 101219148
SB  - IM
MH  - *Civilization
MH  - Developing Countries
MH  - *Ethics
MH  - Europe
MH  - Forecasting
MH  - Humans
MH  - Internationality
MH  - Morals
MH  - Prejudice
MH  - *Science
MH  - *Social Values
EDAT- 2010/04/09 06:00
MHDA- 2010/05/15 06:00
CRDT- 2010/04/09 06:00
PHST- 2010/04/09 06:00 [entrez]
PHST- 2010/04/09 06:00 [pubmed]
PHST- 2010/05/15 06:00 [medline]
PST - ppublish
SO  - Rev Med Suisse. 2010 Mar 10;6(239):532-3.


PMID- 20373668
OWN - NLM
STAT- MEDLINE
DCOM- 20100426
LR  - 20211203
IS  - 1294-8322 (Print)
IS  - 1294-8322 (Linking)
VI  - 12
IP  - 1
DP  - 2010
TI  - Psychiatric pharmacogenomic testing in clinical practice.
PG  - 69-76
AB  - The clinical adoption of psychiatric pharmacogenomic testing has taken place
      rapidly over the past 7 years. Initially, drug-metabolizing enzyme genes, such as
      the cytochrome P450 2D6 gene (CYP2D6), were identified. Genotyping the highly
      variable cytochrome P450 2D6 gene now provides clinicians with the opportunity to
      identify both poor metabolizers and ultrarapid metabolizers of 2D6 substrate
      medications. Subsequently, genes influencing the pharmacodynamic response of
      medications have been made available for clinical practice. Among the earliest
      "target genes" was the serotonin transporter gene (SLC6A4) which has variants
      that have been shown to influence the clinical response of patients of European
      ancestry when they are treated with selective serotonin reuptake inhibitors.
      Genotyping of some of the serotonin receptor genes is also available to guide
      clinical practice. The quantification of the clinical utility of pharmacogenomic 
      testing is evolving, and ethical considerations for testing have been
      established. Given the increasingly clear cost-effectiveness of genotyping, it
      has recently been predicted that pharmacogenomic testing will routinely be
      ordered to guide the selection and dosing of psychotropic medications.
FAU - Mrazek, David A
AU  - Mrazek DA
AD  - Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA. 
      mrazek.david@mayo.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Dialogues Clin Neurosci
JT  - Dialogues in clinical neuroscience
JID - 101238198
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP2D6)
SB  - IM
MH  - Clinical Trials as Topic/*methods
MH  - Cytochrome P-450 CYP2D6/genetics
MH  - Humans
MH  - Mental Disorders/*drug therapy/*genetics
MH  - Pharmacogenetics/*methods
MH  - Serotonin Plasma Membrane Transport Proteins/genetics
MH  - Whites
RF  - 32
PMC - PMC3181940
EDAT- 2010/04/09 06:00
MHDA- 2010/04/27 06:00
CRDT- 2010/04/09 06:00
PHST- 2010/04/09 06:00 [entrez]
PHST- 2010/04/09 06:00 [pubmed]
PHST- 2010/04/27 06:00 [medline]
PST - ppublish
SO  - Dialogues Clin Neurosci. 2010;12(1):69-76.


PMID- 20373666
OWN - NLM
STAT- MEDLINE
DCOM- 20100426
LR  - 20211020
IS  - 1294-8322 (Print)
IS  - 1294-8322 (Linking)
VI  - 12
IP  - 1
DP  - 2010
TI  - Personal genomes in progress: from the human genome project to the personal
      genome project.
PG  - 47-60
AB  - The cost of a diploid human genome sequence has dropped from about $70M to $2000 
      since 2007--even as the standards for redundancy have increased from 7x to 40x in
      order to improve call rates. Coupled with the low return on investment for common
      single-nucleotide polylmorphisms, this has caused a significant rise in interest 
      in correlating genome sequences with comprehensive environmental and trait data
      (GET). The cost of electronic health records, imaging, and microbial,
      immunological, and behavioral data are also dropping quickly. Sharing such
      integrated GET datasets and their interpretations with a diversity of researchers
      and research subjects highlights the need for informed-consent models capable of 
      addressing novel privacy and other issues, as well as for flexible data-sharing
      resources that make materials and data available with minimum restrictions on
      use. This article examines the Personal Genome Project's effort to develop a GET 
      database as a public genomics resource broadly accessible to both researchers and
      research participants, while pursuing the highest standards in research ethics.
FAU - Lunshof, Jeantine E
AU  - Lunshof JE
AD  - European Centre for Public Health Genomics, FHML, Maastricht University,
      Maastricht, The Netherlands.
FAU - Bobe, Jason
AU  - Bobe J
FAU - Aach, John
AU  - Aach J
FAU - Angrist, Misha
AU  - Angrist M
FAU - Thakuria, Joseph V
AU  - Thakuria JV
FAU - Vorhaus, Daniel B
AU  - Vorhaus DB
FAU - Hoehe, Margret R
AU  - Hoehe MR
FAU - Church, George M
AU  - Church GM
LA  - eng
PT  - Journal Article
PL  - England
TA  - Dialogues Clin Neurosci
JT  - Dialogues in clinical neuroscience
JID - 101238198
SB  - IM
MH  - Computational Biology/methods
MH  - Databases, Genetic/economics/statistics & numerical data
MH  - Electronic Health Records/economics/statistics & numerical data
MH  - Environment
MH  - *Genetic Privacy
MH  - Genome, Human/*physiology
MH  - *Human Genome Project/economics
MH  - Humans
PMC - PMC3181947
EDAT- 2010/04/09 06:00
MHDA- 2010/04/27 06:00
CRDT- 2010/04/09 06:00
PHST- 2010/04/09 06:00 [entrez]
PHST- 2010/04/09 06:00 [pubmed]
PHST- 2010/04/27 06:00 [medline]
PST - ppublish
SO  - Dialogues Clin Neurosci. 2010;12(1):47-60.


PMID- 20373459
OWN - NLM
STAT- MEDLINE
DCOM- 20101012
LR  - 20211203
IS  - 1527-6473 (Electronic)
IS  - 1527-6465 (Linking)
VI  - 16
IP  - 4
DP  - 2010 Apr
TI  - Paired donor interchange to avoid ABO-incompatible living donor liver
      transplantation.
PG  - 478-81
LID - 10.1002/lt.21970 [doi]
AB  - We report an emergency paired donor interchange living donor liver transplant
      performed on January 13, 2009. The 4 operations (2 liver transplants) were
      performed simultaneously. The aim was to avoid 2 ABO-incompatible liver
      transplants. One recipient in acute liver failure underwent transplantation in a 
      high-urgency situation. The abdomen of the other recipient had severe adhesions
      from previous spontaneous bacterial peritonitis that rendered the recipient
      operation almost impossible. The ethical and logistical issues are discussed.
      Approaches adopted in anticipation of potential adverse outcomes are explained in
      view of the higher donor and recipient mortality and morbidity rates in
      comparison with kidney transplantation.
CI  - (c) 2010 AASLD.
FAU - Chan, See Ching
AU  - Chan SC
AD  - Department of Surgery, Queen Mary Hospital, University of Hong Kong, Hong Kong,
      China.
FAU - Lo, Chung Mau
AU  - Lo CM
FAU - Yong, Boon Hun
AU  - Yong BH
FAU - Tsui, Wilson J C
AU  - Tsui WJ
FAU - Ng, Kelvin K C
AU  - Ng KK
FAU - Fan, Sheung Tat
AU  - Fan ST
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Liver Transpl
JT  - Liver transplantation : official publication of the American Association for the 
      Study of Liver Diseases and the International Liver Transplantation Society
JID - 100909185
RN  - 0 (ABO Blood-Group System)
RN  - 0 (Immunosuppressive Agents)
SB  - IM
CIN - Liver Transpl. 2010 Apr;16(4):423-5. PMID: 20373453
CIN - Liver Transpl. 2010 Nov;16(11):1332-3; author reply 1334-5. PMID: 21031550
MH  - ABO Blood-Group System/*immunology
MH  - Adolescent
MH  - Adult
MH  - Blood Group Incompatibility/*immunology
MH  - Female
MH  - Graft Survival
MH  - Humans
MH  - Immunosuppression Therapy
MH  - Immunosuppressive Agents/therapeutic use
MH  - Liver/immunology/pathology
MH  - Liver Transplantation/*methods
MH  - Living Donors
MH  - Male
MH  - Middle Aged
MH  - Organ Size
MH  - Treatment Outcome
EDAT- 2010/04/08 06:00
MHDA- 2010/10/13 06:00
CRDT- 2010/04/08 06:00
PHST- 2010/04/08 06:00 [entrez]
PHST- 2010/04/08 06:00 [pubmed]
PHST- 2010/10/13 06:00 [medline]
AID - 10.1002/lt.21970 [doi]
PST - ppublish
SO  - Liver Transpl. 2010 Apr;16(4):478-81. doi: 10.1002/lt.21970.


PMID- 20373223
OWN - NLM
STAT- MEDLINE
DCOM- 20100825
LR  - 20151119
IS  - 1744-4144 (Electronic)
IS  - 1385-4046 (Linking)
VI  - 24
IP  - 3
DP  - 2010 Apr
TI  - Third party observation during neuropsychological evaluation: an update on the
      literature, practical advice for practitioners, and future directions.
PG  - 518-37
LID - 10.1080/13854041003775347 [doi]
AB  - A clash between neuropsychology and the law may exist when a demand is made for
      third party observation during forensic neuropsychological evaluation. Third
      party observation includes any person or observational process present during a
      neuropsychological evaluation aside from the psychologist and the examinee,
      including electronic devices (e.g., video and audio recordings). The goal of this
      paper includes succinctly providing to practitioners the scientific, ethical, and
      pragmatic (i.e., test security and coaching) reasons to not allow third party
      observation. Practitioners at the individual level need to be aware of the
      reasoning and be willing and able to advocate protecting the boundaries of
      neuropsychological practice and test security. We present practitioners with
      options when confronted with a request, provide a list of resources to educate
      the legal system and submit with motions, provide responses for some of the more 
      common myths/reasoning used to support a request for a TPO, and encourage more
      global solutions such as state-by-state legislation.
FAU - Howe, Laura L S
AU  - Howe LL
AD  - VA Palo Alto Health Care System, Palo Alto, CA 94304, USA. lauralshowe@yahoo.com
FAU - McCaffrey, Robert J
AU  - McCaffrey RJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Neuropsychol
JT  - The Clinical neuropsychologist
JID - 8806548
SB  - IM
MH  - Confidentiality/ethics/*legislation & jurisprudence/trends
MH  - *Ethics, Medical
MH  - Humans
MH  - Legislation, Medical
MH  - Neuropsychology/ethics/*legislation & jurisprudence/trends
MH  - *Physician's Role
MH  - Practice Guidelines as Topic
MH  - *Practice Patterns, Physicians'
MH  - Third-Party Consent/ethics/*legislation & jurisprudence
MH  - United States
EDAT- 2010/04/08 06:00
MHDA- 2010/08/26 06:00
CRDT- 2010/04/08 06:00
PHST- 2010/04/08 06:00 [entrez]
PHST- 2010/04/08 06:00 [pubmed]
PHST- 2010/08/26 06:00 [medline]
AID - 920950748 [pii]
AID - 10.1080/13854041003775347 [doi]
PST - ppublish
SO  - Clin Neuropsychol. 2010 Apr;24(3):518-37. doi: 10.1080/13854041003775347.


PMID- 20373222
OWN - NLM
STAT- MEDLINE
DCOM- 20100825
LR  - 20211020
IS  - 1744-4144 (Electronic)
IS  - 1385-4046 (Linking)
VI  - 24
IP  - 3
DP  - 2010 Apr
TI  - Increasing culturally competent neuropsychological services for ethnic minority
      populations: a call to action.
PG  - 429-53
LID - 10.1080/13854040903058960 [doi]
AB  - US demographic and sociopolitical shifts have resulted in a rapidly growing need 
      for culturally competent neuropsychological services. However, clinical
      neuropsychology as a field has not kept pace with the needs of ethnic minority
      clients. In this discussion we review: historical precedents and the limits of
      universalism in neuropsychology; ethical/professional guidelines pertinent to
      neuropsychological practice with ethnic minority clients; critical cultural
      considerations in neuropsychology; current disparities germane to practice; and
      challenges to the provision of services to racial/ethnic minority clients. We
      provide a call to action for neuropsychologists and related organizations to
      advance multiculturalism and diversity within the field by increasing
      multicultural awareness and knowledge, multicultural education and training,
      multicultural neuropsychological research, and the provision of culturally
      competent neuropsychological services to racial/ethnic minority clients. Lastly, 
      we discuss strategies for increasing the provision of culturally competent
      neuropsychological services, and offer several resources to meet these goals.
FAU - Rivera Mindt, Monica
AU  - Rivera Mindt M
AD  - Department of Psychology, Fordham University, New York, NY, USA.
      monica.mindt@mssm.edu
FAU - Byrd, Desiree
AU  - Byrd D
FAU - Saez, Pedro
AU  - Saez P
FAU - Manly, Jennifer
AU  - Manly J
LA  - eng
GR  - K23 MH079718-02/MH/NIMH NIH HHS/United States
GR  - 1K23MH07 971 801/MH/NIMH NIH HHS/United States
GR  - K23 MH079718/MH/NIMH NIH HHS/United States
GR  - K23 MH079718-03/MH/NIMH NIH HHS/United States
GR  - K23 MH079718-01A1/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Clin Neuropsychol
JT  - The Clinical neuropsychologist
JID - 8806548
SB  - IM
MH  - Cultural Characteristics
MH  - Cultural Competency/*psychology
MH  - *Health Services Needs and Demand
MH  - Healthcare Disparities/methods
MH  - Humans
MH  - *Mental Health Services
MH  - Minority Groups/*psychology
MH  - *Neuropsychology
MH  - *Practice Patterns, Physicians'
MH  - United States
RF  - 79
PMC - PMC2909768
MID - NIHMS221195
EDAT- 2010/04/08 06:00
MHDA- 2010/08/26 06:00
CRDT- 2010/04/08 06:00
PHST- 2010/04/08 06:00 [entrez]
PHST- 2010/04/08 06:00 [pubmed]
PHST- 2010/08/26 06:00 [medline]
AID - 920951034 [pii]
AID - 10.1080/13854040903058960 [doi]
PST - ppublish
SO  - Clin Neuropsychol. 2010 Apr;24(3):429-53. doi: 10.1080/13854040903058960.


PMID- 20373143
OWN - NLM
STAT- MEDLINE
DCOM- 20110128
LR  - 20220419
IS  - 1573-2665 (Electronic)
IS  - 0141-8955 (Linking)
VI  - 33
IP  - 5
DP  - 2010 Oct
TI  - Newborn screening for disorders of fatty-acid oxidation: experience and
      recommendations from an expert meeting.
PG  - 521-6
LID - 10.1007/s10545-010-9076-8 [doi]
AB  - Experience with new-born screening (NBS) for disorders of fatty-acid oxidation
      (FAOD) is now becoming available from an increasing number of programs worldwide.
      The spectrum of FAOD differs widely between ethnic groups. Incidence calculations
      from reports from Australia, Germany, and the USA of a total of 5,256,999
      newborns give a combined incidence of all FAOD of approximately 1:9,300. However,
      it appears to be much lower in Asians. Consequently, a significant prevalence and
      evidence for a clear benefit of NBS is proven for medium-chain acyl-CoA
      dehydrogenase deficiency (MCAD) only in countries with a high percentage of
      Caucasians, with very-long-chain acyl-CoA dehydrogenase deficiency (VLCAD) and
      long-chain 3-hydroxy acyl-CoA dehydrogenase deficiency (LCHAD) being additional
      candidates. The long-term benefit for many disorders has still to be evaluated
      and will require international collaboration, especially for the rarest
      disorders. Short-chain acyl-CoA dehydrogenase deficiency (SCAD) [as well as
      Systemic carnitine transporter deficiency (CTD) and dienoyl-CoA reductase
      deficiency (DE-RED)] are conditions of uncertain clinical significance, but most 
      FAOD have a spectrum of clinical presentations (healthy-death). Confirmatory
      diagnostic procedures should be agreed upon to ensure international comparability
      of results and evidence-based modifications. The case of short-chain acyl-CoA
      dehydrogenase deficiency (SCAD) deficiency shows that even inclusion of
      conditions without a clearly known natural course may prove useful with respect
      to gain of knowledge and consecutive exclusion of a biochemical abnormality
      without clinical significance, although this line of argument implies the
      existence of structured follow-up programs and bears ethical controversies. As a 
      final conclusion, the accumulated evidence suggests all FAOD should to be
      included into tandem mass spectrometry (MS/MS)-based NBS programs provided
      sufficient laboratory performance is guaranteed.
FAU - Lindner, Martin
AU  - Lindner M
AD  - University Children's Hospital, Heidelberg, Germany.
      Martin.lindner@med.uni-heidelberg.de
FAU - Hoffmann, Georg F
AU  - Hoffmann GF
FAU - Matern, Dietrich
AU  - Matern D
LA  - eng
PT  - Consensus Development Conference
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100407
PL  - United States
TA  - J Inherit Metab Dis
JT  - Journal of inherited metabolic disease
JID - 7910918
RN  - 0 (Fatty Acids)
SB  - IM
MH  - *Energy Metabolism/genetics
MH  - Fatty Acids/*metabolism
MH  - Genotype
MH  - Humans
MH  - Infant, Newborn
MH  - Lipid Metabolism, Inborn Errors/*diagnosis/enzymology/ethnology/genetics
MH  - Mitochondria/*enzymology
MH  - Mitochondrial Diseases/*diagnosis/enzymology/ethnology/genetics
MH  - *Neonatal Screening/standards
MH  - Oxidation-Reduction
MH  - Phenotype
MH  - Practice Guidelines as Topic
MH  - Predictive Value of Tests
EDAT- 2010/04/08 06:00
MHDA- 2011/02/01 06:00
CRDT- 2010/04/08 06:00
PHST- 2009/10/22 00:00 [received]
PHST- 2010/03/02 00:00 [accepted]
PHST- 2010/02/24 00:00 [revised]
PHST- 2010/04/08 06:00 [entrez]
PHST- 2010/04/08 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
AID - 10.1007/s10545-010-9076-8 [doi]
PST - ppublish
SO  - J Inherit Metab Dis. 2010 Oct;33(5):521-6. doi: 10.1007/s10545-010-9076-8. Epub
      2010 Apr 7.


PMID- 20371527
OWN - NLM
STAT- MEDLINE
DCOM- 20100429
LR  - 20181204
IS  - 1931-3543 (Electronic)
IS  - 0012-3692 (Linking)
VI  - 137
IP  - 4
DP  - 2010 Apr
TI  - Compromised autonomy and the seriously ill patient.
PG  - 926-31
LID - 10.1378/chest.09-1574 [doi]
AB  - Respect for patient autonomy has become the preeminent principle of medical
      ethics, to the point that tools have been developed, such as instructive
      directives, in an attempt to preserve a semblance of autonomy even when it has
      become clearly and irretrievably lost. Much of the practice around the respect
      for autonomy, however, mistakenly supposes that the capacity for autonomous
      choice is an all-or-nothing proposition. But seriously ill patients may retain
      some ability to participate in discussions of medical care yet have their
      autonomy profoundly compromised by physical duress, cognitive dysfunction, or
      delirium. The choices of individuals with compromised autonomy do not carry the
      same moral weight as those of the fully autonomous. Clinicians, therefore, cannot
      rely on such choices for guiding medical decisions and are obligated to evaluate 
      them more fully before acting. We argue that clinicians should compare the
      choices of individuals with compromised autonomy to a medical assessment of the
      patient's best interest. When the patient's choice and the best-interests
      assessment are discordant, acting in the patient's best interest may, at times,
      rightly override the requests of the patient. Such an approach, under a tightly
      constrained set of circumstances, would permit both the provision and the
      withholding of medical interventions despite patient requests to the contrary.
FAU - Tonelli, Mark R
AU  - Tonelli MR
AD  - Department of Medicine, University of Washington, 1959 NE Pacific St, Box 356522,
      Seattle, WA 98195-6522, USA. tonelli@u.washington.edu
FAU - Misak, Cheryl J
AU  - Misak CJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Chest
JT  - Chest
JID - 0231335
SB  - IM
CIN - Chest. 2010 Oct;138(4):1021-2; author reply 1022-3. PMID: 20923809
CIN - Chest. 2011 Feb;139(2):476; author reply 476-7. PMID: 21285068
MH  - Critical Illness/*therapy
MH  - Decision Making/*ethics
MH  - *Ethics, Medical
MH  - Humans
MH  - Patient Participation
MH  - Patient Rights/ethics
MH  - *Personal Autonomy
EDAT- 2010/04/08 06:00
MHDA- 2010/04/30 06:00
CRDT- 2010/04/08 06:00
PHST- 2010/04/08 06:00 [entrez]
PHST- 2010/04/08 06:00 [pubmed]
PHST- 2010/04/30 06:00 [medline]
AID - S0012-3692(10)60199-7 [pii]
AID - 10.1378/chest.09-1574 [doi]
PST - ppublish
SO  - Chest. 2010 Apr;137(4):926-31. doi: 10.1378/chest.09-1574.


PMID- 20371476
OWN - NLM
STAT- MEDLINE
DCOM- 20100621
LR  - 20100407
IS  - 1946-6242 (Electronic)
IS  - 1946-6234 (Linking)
VI  - 2
IP  - 17
DP  - 2010 Feb 3
TI  - Bioethical and clinical dilemmas of direct-to-consumer personal genomic testing: 
      the problem of misattributed equivalence.
PG  - 17cm5
LID - 10.1126/scitranslmed.3000214 [doi]
AB  - A number of for-profit companies now provide personal genomic testing services to
      clients directly, without input from a physician or other health care provider,
      and the results of these tests include predictions about a broad spectrum of
      disease risks and traits. Validated clinical genetic testing and
      direct-to-consumer (DTC) genomic tests differ substantially in their reliability 
      and usefulness, raising many clinical, ethical, and societal challenges, which
      are discussed in this Commentary. Of special concern is the problem of
      misattributed equivalence, which occurs when a patient or physician mistakenly
      views alternative methods of genetic evaluation as equivalent in their results
      and analytic rigor. Despite the many challenges raised by DTC genomic testing, we
      are reminded that commercial interests have sometimes acted as a disruptive force
      or technology that drives nonconventional approaches to difficult problems.
FAU - Eng, Charis
AU  - Eng C
AD  - Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
      engc@ccf.org
FAU - Sharp, Richard R
AU  - Sharp RR
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Sci Transl Med
JT  - Science translational medicine
JID - 101505086
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Genetic Counseling/ethics/*methods
MH  - Genetic Privacy/ethics
MH  - *Genetic Testing
MH  - Genome, Human
MH  - Genomics
MH  - Humans
MH  - Male
MH  - Marketing of Health Services/ethics
MH  - Middle Aged
MH  - Neoplasms/diagnosis/genetics
MH  - Pedigree
MH  - Polymorphism, Single Nucleotide
MH  - Risk Assessment/ethics
EDAT- 2010/04/08 06:00
MHDA- 2010/06/22 06:00
CRDT- 2010/04/08 06:00
PHST- 2010/04/08 06:00 [entrez]
PHST- 2010/04/08 06:00 [pubmed]
PHST- 2010/06/22 06:00 [medline]
AID - 2/17/17cm5 [pii]
AID - 10.1126/scitranslmed.3000214 [doi]
PST - ppublish
SO  - Sci Transl Med. 2010 Feb 3;2(17):17cm5. doi: 10.1126/scitranslmed.3000214.


PMID- 20371468
OWN - NLM
STAT- MEDLINE
DCOM- 20100628
LR  - 20211203
IS  - 1946-6242 (Electronic)
IS  - 1946-6234 (Linking)
VI  - 2
IP  - 15
DP  - 2010 Jan 20
TI  - Meeting the governance challenges of next-generation biorepository research.
PG  - 15cm3
LID - 10.1126/scitranslmed.3000361 [doi]
AB  - Advances in clinical translational research have led to an explosion of interest 
      in infrastructure development and data sharing facilitated by biorepositories of 
      specimens and linked health information. These efforts are qualitatively
      different from the single-center sample collections that preceded them and pose
      substantial new ethics and regulatory challenges for investigators and
      institutions. New research governance approaches, which can address current and
      anticipated challenges, promote high-quality research, and provide a robust basis
      for ongoing research participation, are urgently required.
FAU - Fullerton, Stephanie M
AU  - Fullerton SM
AD  - Institute of Translational Health Sciences, University of Washington, Seattle, WA
      98195, USA. smfllrtn@u.washington.edu
FAU - Anderson, Nicholas R
AU  - Anderson NR
FAU - Guzauskas, Greg
AU  - Guzauskas G
FAU - Freeman, Dena
AU  - Freeman D
FAU - Fryer-Edwards, Kelly
AU  - Fryer-Edwards K
LA  - eng
GR  - UL1 RR025014-03/RR/NCRR NIH HHS/United States
GR  - P30 ES07033/ES/NIEHS NIH HHS/United States
GR  - P30 ES007033/ES/NIEHS NIH HHS/United States
GR  - TL1 RR025016/RR/NCRR NIH HHS/United States
GR  - KL2 RR025015/RR/NCRR NIH HHS/United States
GR  - TL1 RR025016-03/RR/NCRR NIH HHS/United States
GR  - KL2 RR 025015/RR/NCRR NIH HHS/United States
GR  - UL1 RR025014/RR/NCRR NIH HHS/United States
GR  - TL1 RR 025016/RR/NCRR NIH HHS/United States
GR  - KL2 RR025015-03/RR/NCRR NIH HHS/United States
GR  - P50 HG003374/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Sci Transl Med
JT  - Science translational medicine
JID - 101505086
SB  - IM
MH  - Anonymous Testing
MH  - Biological Specimen Banks/*organization & administration
MH  - Biomedical Research/*organization & administration
MH  - Humans
MH  - Translational Research, Biomedical/organization & administration/trends
PMC - PMC3038212
MID - NIHMS267624
EDAT- 2010/04/08 06:00
MHDA- 2010/06/29 06:00
CRDT- 2010/04/08 06:00
PHST- 2010/04/08 06:00 [entrez]
PHST- 2010/04/08 06:00 [pubmed]
PHST- 2010/06/29 06:00 [medline]
AID - 2/15/15cm3 [pii]
AID - 10.1126/scitranslmed.3000361 [doi]
PST - ppublish
SO  - Sci Transl Med. 2010 Jan 20;2(15):15cm3. doi: 10.1126/scitranslmed.3000361.


PMID- 20371375
OWN - NLM
STAT- MEDLINE
DCOM- 20100719
LR  - 20131121
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 476
IP  - 1
DP  - 2010 May 26
TI  - Acquisition and performance in a rat sequential reaction time task is not
      affected by subtotal ventral striatal 6-OHDA lesions.
PG  - 27-31
LID - 10.1016/j.neulet.2010.03.075 [doi]
AB  - Based on findings of experiments with humans, non-human primates and rodents, it 
      is commonly accepted that dopaminergic basal ganglia processes play a crucial
      role in procedural and sequential learning. Primal evidence for this hypothesis
      came from serial reaction time tasks (SRTT) studies, demonstrating that healthy
      controls show increased reaction times when visual stimulus presentation switches
      from a previously learned sequence to random stimulus presentation. This
      so-called interference effect was reduced in patients with Parkinson's disease.
      Since ethical and methodical aspects limit neurobiological research in human
      subjects, we developed a rat version of the human SRTT, which can be used to
      study experimentally induced brain damage. In the present experiment we
      investigated the effects of bilateral 6-OHDA lesions of the ventral striatum on
      sequential learning. The lesions led to subtotal dopaminergic depletions in the
      ventral striatum (58-60%) and also minor depletions in the medial neostriatum
      (32-46%). These lesions impaired task acquisition only moderately and did not
      worsen sequential performance since lesion and control animals showed a
      comparable interference effect when the trained sequence was tested against
      random stimulus presentation or violated sequences. In contrast, in an earlier
      SRTT experiment with medial neostriatal dopaminergic lesions (58-66%), the lesion
      animals were clearly impaired in their sequential learning as compared to
      controls. Therefore, we assume that subtotal dopamine loss in the medial
      neostriatum, rather than the ventral striatum, has a substantial effect on
      sequential learning.
CI  - Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Eckart, M T
AU  - Eckart MT
AD  - Philipps-University of Marburg, Department of Psychology, Experimental and
      Physiological Psychology, Gutenbergstrasse 18, D-35032 Marburg, Germany.
      eckart@staff.uni-marburg.de
FAU - Huelse-Matia, M C
AU  - Huelse-Matia MC
FAU - Loer, D
AU  - Loer D
FAU - Schwarting, R K W
AU  - Schwarting RK
LA  - eng
PT  - Journal Article
DEP - 20100404
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 8HW4YBZ748 (Oxidopamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Corpus Striatum/*drug effects/physiology
MH  - Dopamine/metabolism
MH  - Male
MH  - Oxidopamine/*toxicity
MH  - Rats
MH  - Rats, Wistar
MH  - Reaction Time/drug effects
MH  - *Serial Learning
EDAT- 2010/04/08 06:00
MHDA- 2010/07/20 06:00
CRDT- 2010/04/08 06:00
PHST- 2010/01/28 00:00 [received]
PHST- 2010/03/20 00:00 [revised]
PHST- 2010/03/30 00:00 [accepted]
PHST- 2010/04/08 06:00 [entrez]
PHST- 2010/04/08 06:00 [pubmed]
PHST- 2010/07/20 06:00 [medline]
AID - S0304-3940(10)00396-4 [pii]
AID - 10.1016/j.neulet.2010.03.075 [doi]
PST - ppublish
SO  - Neurosci Lett. 2010 May 26;476(1):27-31. doi: 10.1016/j.neulet.2010.03.075. Epub 
      2010 Apr 4.


PMID- 20371053
OWN - NLM
STAT- MEDLINE
DCOM- 20100422
LR  - 20211020
IS  - 1557-8240 (Electronic)
IS  - 0031-3955 (Linking)
VI  - 57
IP  - 2
DP  - 2010 Apr
TI  - The adolescent transplant recipient.
PG  - 575-92, table of contents
LID - 10.1016/j.pcl.2010.01.013 [doi]
AB  - Adolescents constitute a significant proportion of pediatric transplant patients,
      whether they have survived a transplant in early childhood (like most heart and
      liver recipients) or are transplanted in older childhood or adolescence, such as 
      many renal transplant recipients. Their needs can be significantly different from
      either children or adults, as they are undergoing a major transformation that
      involves making educational and vocational decisions and commitments,
      establishing a new and more equal relationship with their parents, discovering
      their sexual identity, taking increasing responsibility for their health and
      creating the moral, philosophic, and ethical perspective that they will carry
      through their lives. This article discusses adolescent issues in transplantation.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Kaufman, Miriam
AU  - Kaufman M
AD  - The Transplant Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8,
      Canada. miriam.kaufman@sickkids.ca
FAU - Shemesh, Eyal
AU  - Shemesh E
FAU - Benton, Tami
AU  - Benton T
LA  - eng
GR  - R01 DK080740/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Pediatr Clin North Am
JT  - Pediatric clinics of North America
JID - 0401126
SB  - IM
MH  - *Adaptation, Psychological
MH  - Adolescent
MH  - Female
MH  - Human Development
MH  - Humans
MH  - Male
MH  - Medication Adherence
MH  - Mental Disorders/prevention & control
MH  - Organ Transplantation/adverse effects/*psychology/*rehabilitation
MH  - *Patient Care Planning
MH  - Puberty
MH  - Sexuality
MH  - *Social Adjustment
RF  - 66
EDAT- 2010/04/08 06:00
MHDA- 2010/04/23 06:00
CRDT- 2010/04/08 06:00
PHST- 2010/04/08 06:00 [entrez]
PHST- 2010/04/08 06:00 [pubmed]
PHST- 2010/04/23 06:00 [medline]
AID - S0031-3955(10)00014-3 [pii]
AID - 10.1016/j.pcl.2010.01.013 [doi]
PST - ppublish
SO  - Pediatr Clin North Am. 2010 Apr;57(2):575-92, table of contents. doi:
      10.1016/j.pcl.2010.01.013.


PMID- 20370996
OWN - NLM
STAT- MEDLINE
DCOM- 20101104
LR  - 20191111
IS  - 1488-2353 (Electronic)
IS  - 0147-958X (Linking)
VI  - 33
IP  - 2
DP  - 2010 Apr 1
TI  - Peak expiratory flow values are higher in older and taller healthy male children:
      an observational study.
PG  - E92
AB  - PURPOSE: Peak expiratory flow (PEF) was measured in healthy children aged five to
      ten years in order to provide baseline values and to determine correlations
      between PEF and factors such as gender, age and type of school. METHODS: After
      the Ethical Committee of Research in Human of the School of Medicine of ABC -
      FMABC approval, PEF and height were measured in 1942 children between five and
      ten years old from nine public schools and nine private schools throughout Sao
      Bernardo do Campo City. PEF was measured using the Mini-Wright Peak Flow Meter
      (Clement Clarke International Ltd.) and. height was measured using a Sanny
      professional stadiometer . RESULTS: Significant differences were found in values 
      for PEF: higher values were seen in older students in comparison with younger
      students, in males in comparison with females and in students from private
      schools in comparison with public schools, with average values ranging from 206
      L/min to 248 L/min,. Linear correlations were seen for PEF values with both
      height and age (Spearman Coefficient). CONCLUSIONS: Differences were seen for PEF
      between genders and between types of school, and a linear correlation was seen
      for PEF with both age and height in healthy children from five to ten years old.
FAU - Radziavicius, Fernanda R
AU  - Radziavicius FR
AD  - Department of Morphology and Physiology, School of Medicine of ABC, 09060-650
      Santo Andre, SP, Brazil.
FAU - Martins, Lourdes C
AU  - Martins LC
FAU - Radziavicius, Camilla C
AU  - Radziavicius CC
FAU - Valenti, Vitor E
AU  - Valenti VE
FAU - Siqueira, Arnaldo A F
AU  - Siqueira AA
FAU - de Souza, Cintia G
AU  - de Souza CG
FAU - de Abreu, Luiz C
AU  - de Abreu LC
LA  - eng
PT  - Journal Article
DEP - 20100401
PL  - Canada
TA  - Clin Invest Med
JT  - Clinical and investigative medicine. Medecine clinique et experimentale
JID - 7804071
SB  - IM
MH  - Aging/*physiology
MH  - Body Height/*physiology
MH  - Brazil
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - *Health
MH  - Humans
MH  - Male
MH  - Peak Expiratory Flow Rate/*physiology
MH  - Schools
MH  - Sex Characteristics
EDAT- 2010/04/08 06:00
MHDA- 2010/11/05 06:00
CRDT- 2010/04/08 06:00
PHST- 2010/04/06 00:00 [received]
PHST- 2010/04/08 06:00 [entrez]
PHST- 2010/04/08 06:00 [pubmed]
PHST- 2010/11/05 06:00 [medline]
AID - 10.25011/cim.v33i2.12347 [doi]
PST - epublish
SO  - Clin Invest Med. 2010 Apr 1;33(2):E92. doi: 10.25011/cim.v33i2.12347.


PMID- 20370983
OWN - NLM
STAT- MEDLINE
DCOM- 20100422
LR  - 20170926
IS  - 1701-2163 (Print)
IS  - 1701-2163 (Linking)
VI  - 32
IP  - 1
DP  - 2010 Jan
TI  - Use of umbilical cord blood for stem cell research.
PG  - 58-61
LID - S1701-2163(16)34406-1 [pii]
LID - 10.1016/S1701-2163(16)34406-1 [doi]
AB  - Umbilical cord blood (UCB), long treated as waste material, is today considered a
      valuable source of hematopoietic stem cells. UCB is used, mostly in children, for
      the treatment of blood malignancies and inherited blood and metabolic disorders. 
      In addition to blood precursor cells, UCB also contains stem cells that can
      differentiate into other types, such as cartilage, fat, hepatic, cardiac, and
      neural cells, fuelling speculation about the use of cord blood stem cells for
      regenerative medicine. Further research is therefore needed to investigate the
      expanded potential of UCB and its therapeutic use in cell and tissue therapies.
      According to a recent survey, practices for the procurement of UCB for research
      vary widely across Canada, so this area may not yet be ready for uniform
      regulation. However, some harmonization of practices to increase the availability
      of UCB for research would be useful for Canadian investigators. In this article, 
      we address several important ethical and legal issues relating to the use of UCB 
      in research and recommend guidelines to serve as a source of useful information
      for researchers. While their legal acceptability may vary across Canada, it is
      hoped that these recommendations foster more harmonized UCB research practices.
FAU - Bordet, Sylvie
AU  - Bordet S
AD  - Centre of Genomics and Policy, Faculty of Medicine, Department of Human Genetics,
      McGill University, Montreal QC.
FAU - Nguyen, Thu Minh
AU  - Nguyen TM
AD  - Centre of Genomics and Policy, Faculty of Medicine, Department of Human Genetics,
      McGill University, Montreal QC.
FAU - Knoppers, Bartha Maria
AU  - Knoppers BM
AD  - Centre of Genomics and Policy, Faculty of Medicine, Department of Human Genetics,
      McGill University, Montreal QC.
FAU - Isasi, Rosario
AU  - Isasi R
AD  - Centre of Genomics and Policy, Faculty of Medicine, Department of Human Genetics,
      McGill University, Montreal QC.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Obstet Gynaecol Can
JT  - Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et
      gynecologie du Canada : JOGC
JID - 101126664
SB  - IM
MH  - Biomedical Research/ethics/legislation & jurisprudence
MH  - Blood Banks
MH  - Clinical Trials as Topic
MH  - Female
MH  - Fetal Blood/*cytology
MH  - *Hematopoietic Stem Cell Transplantation
MH  - *Hematopoietic Stem Cells
MH  - Humans
MH  - Informed Consent
MH  - Patient Education as Topic
MH  - Pregnancy
MH  - Tissue Donors/education
EDAT- 2010/04/08 06:00
MHDA- 2010/04/23 06:00
CRDT- 2010/04/08 06:00
PHST- 2010/04/08 06:00 [entrez]
PHST- 2010/04/08 06:00 [pubmed]
PHST- 2010/04/23 06:00 [medline]
AID - S1701-2163(16)34406-1 [pii]
AID - 10.1016/S1701-2163(16)34406-1 [doi]
PST - ppublish
SO  - J Obstet Gynaecol Can. 2010 Jan;32(1):58-61. doi: 10.1016/S1701-2163(16)34406-1.


PMID- 20370982
OWN - NLM
STAT- MEDLINE
DCOM- 20100422
LR  - 20170926
IS  - 1701-2163 (Print)
IS  - 1701-2163 (Linking)
VI  - 32
IP  - 1
DP  - 2010 Jan
TI  - Towards an ethical policy for the prevention of fetal sex selection in Canada.
PG  - 54-57
LID - S1701-2163(16)34405-X [pii]
LID - 10.1016/S1701-2163(16)34405-X [doi]
AB  - The troubling practice of fetal sex selection has historically been considered an
      Asian phenomenon. However, recent evidence shows that a similar situation is
      emerging in North America, albeit on a smaller scale. The Society of
      Obstetricians and Gynaecologists of Canada has firmly stated its opposition to
      sex selection for non-medical reasons, as well as to the use of any technology
      used solely for the purpose of determining fetal sex. However, because fetal sex 
      may be disclosed to the parents at the time of ultrasound examination if they
      request this information, guidance for health care professionals to assist in
      discouraging fetal sex selection would be useful. Because no declaration of
      motives or reasons is required when a woman seeks a termination of pregnancy, we 
      suggest that health care professionals need not disclose the sex of a fetus until
      it has reached a gestational age at which abortion for non-medical purposes would
      not be possible. This proposal would facilitate consistency between clinical
      practice and the values of Canadian citizens, the SOGC, the Canadian Medical
      Association, and other professional organizations, while still respecting current
      laws pertaining to disclosure of patient information and patients' rights to
      autonomous decision-making.
FAU - Thiele, Allison T
AU  - Thiele AT
AD  - College of Medicine, University of Saskatchewan, Regina SK.
FAU - Leier, Brendan
AU  - Leier B
AD  - Clinical Ethicist, University of Alberta and Stollery Children's Hospitals,
      Edmonton AB; Clinical Assistant Professor, John Dossetor Health Ethics Centre and
      Faculty of Medicine and Dentistry, University of Alberta, Edmonton AB.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Obstet Gynaecol Can
JT  - Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et
      gynecologie du Canada : JOGC
JID - 101126664
SB  - IM
MH  - Abortion, Induced/legislation & jurisprudence
MH  - Canada
MH  - Disclosure/legislation & jurisprudence
MH  - Female
MH  - Gestational Age
MH  - *Health Policy
MH  - Humans
MH  - Obstetrics/*ethics
MH  - Patient Access to Records/legislation & jurisprudence
MH  - Patient Rights/legislation & jurisprudence
MH  - Practice Guidelines as Topic
MH  - Pregnancy
MH  - Sex Determination Analysis
MH  - Sex Preselection/*ethics
MH  - Societies, Medical
MH  - Ultrasonography, Prenatal
EDAT- 2010/04/08 06:00
MHDA- 2010/04/23 06:00
CRDT- 2010/04/08 06:00
PHST- 2010/04/08 06:00 [entrez]
PHST- 2010/04/08 06:00 [pubmed]
PHST- 2010/04/23 06:00 [medline]
AID - S1701-2163(16)34405-X [pii]
AID - 10.1016/S1701-2163(16)34405-X [doi]
PST - ppublish
SO  - J Obstet Gynaecol Can. 2010 Jan;32(1):54-57. doi: 10.1016/S1701-2163(16)34405-X.


PMID- 20369759
OWN - NLM
STAT- MEDLINE
DCOM- 20100420
LR  - 20190319
IS  - 0310-057X (Print)
IS  - 0310-057X (Linking)
VI  - 38
IP  - 2
DP  - 2010 Mar
TI  - Associations between cerebrospinal fluid protein concentrations, serum albumin
      concentrations and intracranial pressure in neurotrauma and intracranial
      haemorrhage.
PG  - 274-9
AB  - Recent evidence suggests that using intravenous isotonic albumin solution for
      haemodynamic resuscitation in neurotrauma is associated with adverse outcomes.
      This study assessed the correlations between cerebrospinal fluid protein
      concentrations, serum albumin concentrations and intracranial pressure in a
      cohort of neurosurgical patients. After obtaining ethics committee approval,
      correlations between concomitant cerebrospinal fluid protein concentrations,
      serum albumin concentrations and the mean daily intracranial pressure of 63
      consecutive neurosurgical patients, grouped as neurotrauma or intracranial
      haemorrhage, admitted between 1 January and 31 December 2007, were assessed. The 
      mean daily intracranial pressure was significantly associated with cerebrospinal 
      fluid protein concentrations (Spearman correlation coefficient [SCC] = 0.496, P =
      0.001), white cell counts (SCC = 0.359, P = 0.001), red cell counts (SCC = 0.399,
      P = .0O01) and serum albumin concentrations (SCC = 0.431, P = 0.001) in patients 
      with neurotrauma (n=23). Cerebrospinal fluid protein concentrations were also
      significantly associated with concomitant serum albumin concentrations (SCC =
      0.393, P = 0.001) in these patients. In patients with intracranial haemorrhage
      (n=40), the mean daily intracranial pressure was only significantly associated
      with cerebrospinal fluid white cell and red cell counts but not cerebrospinal
      fluid protein and serum albumin concentrations. In summary, intracranial pressure
      is correlated with cerebrospinal fluid protein and serum albumin concentrations
      in patients with severe neurotrauma, and these suggest that blood-brain barrier
      may not be completely intact after severe neurotrauma.
FAU - Jeffcote, T
AU  - Jeffcote T
AD  - Department of Intensive Care, Royal Perth Hospital, Perth, Western Australia,
      Australia.
FAU - Ho, K M
AU  - Ho KM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Anaesth Intensive Care
JT  - Anaesthesia and intensive care
JID - 0342017
RN  - 0 (Cerebrospinal Fluid Proteins)
RN  - 0 (Serum Albumin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood-Brain Barrier
MH  - Brain Injuries/blood/cerebrospinal fluid/*physiopathology
MH  - Cerebrospinal Fluid Proteins/*analysis
MH  - Female
MH  - Humans
MH  - Intracranial Hemorrhages/blood/cerebrospinal fluid/*physiopathology
MH  - *Intracranial Pressure
MH  - Male
MH  - Middle Aged
MH  - Serum Albumin/*analysis
EDAT- 2010/04/08 06:00
MHDA- 2010/04/21 06:00
CRDT- 2010/04/08 06:00
PHST- 2010/04/08 06:00 [entrez]
PHST- 2010/04/08 06:00 [pubmed]
PHST- 2010/04/21 06:00 [medline]
AID - 20090474 [pii]
AID - 10.1177/0310057X1003800208 [doi]
PST - ppublish
SO  - Anaesth Intensive Care. 2010 Mar;38(2):274-9. doi: 10.1177/0310057X1003800208.


PMID- 20368771
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1687-9759 (Electronic)
IS  - 1687-9740 (Linking)
VI  - 2010
DP  - 2010
TI  - Ethical issues in fetal management: a cardiac perspective.
PG  - 857460
LID - 10.1155/2010/857460 [doi]
AB  - The ethical issues behind the management of a fetus with a serious abnormality
      and the decisions made in relation to the outcome of the pregnancy are complex.
      This reflective paper deals with the ethical principles of managing a pregnancy
      with a congenital anomaly, with particular emphasis on the fetus with a serious
      cardiac abnormality. One major ethical concern is whether the fetus is or is not 
      independent being to whom obligations of beneficence are owed. We review the
      debate on this matter, and suggest that it is ethically more appropriate for
      physicians who are involved in management of fetal abnormality not to adopt and
      insist on their own position on this matter. Rather, the appropriate course is to
      respect the pregnant woman's own view of her fetus and how it should be regarded.
      This is an application of the principle of respect for autonomy. Within this
      framework, we discuss the difficulties in counselling a pregnant woman or
      expectant couple in this situation, and recommend three key steps in ethically
      sound counselling.
FAU - Malhotra, Atul
AU  - Malhotra A
AD  - Department of Neonatology, Monash Medical Centre, 246, Clayton Road, Clayton,
      Melbourne, Victoria 3168, Australia.
FAU - Menahem, Samuel
AU  - Menahem S
FAU - Gillam, Lynn
AU  - Gillam L
LA  - eng
PT  - Journal Article
DEP - 20100324
PL  - Egypt
TA  - Int J Pediatr
JT  - International journal of pediatrics
JID - 101517077
PMC - PMC2846337
EDAT- 2010/04/07 06:00
MHDA- 2010/04/07 06:01
CRDT- 2010/04/07 06:00
PHST- 2009/12/15 00:00 [received]
PHST- 2010/02/23 00:00 [accepted]
PHST- 2010/04/07 06:00 [entrez]
PHST- 2010/04/07 06:00 [pubmed]
PHST- 2010/04/07 06:01 [medline]
AID - 10.1155/2010/857460 [doi]
PST - ppublish
SO  - Int J Pediatr. 2010;2010:857460. doi: 10.1155/2010/857460. Epub 2010 Mar 24.


PMID- 20368484
OWN - NLM
STAT- MEDLINE
DCOM- 20100419
LR  - 20100406
IS  - 1538-3628 (Electronic)
IS  - 1072-4710 (Linking)
VI  - 164
IP  - 4
DP  - 2010 Apr
TI  - Learning that leads to action: impact and characteristics of a professional
      education approach to improve the care of critically ill children and their
      families.
PG  - 315-22
LID - 10.1001/archpediatrics.2010.12 [doi]
AB  - OBJECTIVE: To determine the impact of an innovative professional educational
      approach on clinicians' confidence and ability to make institutional improvements
      in pediatric palliative care. DESIGN: Evaluation to assess impact of educational 
      intervention on participants and participant institutions. SETTING: Retreats
      lasting 2.5 days. PARTICIPANTS: Physicians, nurses, psychosocial staff, and
      bereaved parents. INTERVENTION: "Relational learning across boundaries" pedagogy.
      MAIN OUTCOME MEASURES: Analysis of participant questionnaires (n = 782, response 
      rate of 84%), team leader surveys (n = 72, response rate of 71%), and follow-up
      interview with subsample (n = 21, response rate of 81%). Outcomes included
      confidence to act and institutional improvements achieved. RESULTS: Seventy-four 
      percent of team leaders reported significant or moderate improvement in pediatric
      palliative care after the retreat; only 1% reported no improvement. Ninety-one
      percent credited the retreat experience as being somewhat or very instrumental to
      the improvements, which included the establishment of pediatric palliative care
      and bereavement programs, improvements in interdisciplinary communication, care
      coordination, clinician-family interaction at the bedside, and educational
      programs. Participants attributed the impact of the 2.5-day retreat to its key
      pedagogical features, involvement of family members as equal participants and
      participation of colleagues from other disciplines and care settings, as well as 
      the ground rules used for the small group seminars. CONCLUSIONS: The intervention
      was successful in improving clinicians' confidence and catalyzed improvements in 
      pediatric palliative care within participating institutions. Relational learning 
      holds promise for professional learning, especially when the educational goal is 
      tied to enabling a shift in social and ethical norms.
FAU - Solomon, Mildred Z
AU  - Solomon MZ
AD  - Department of Global Health and Social Medicine, Harvard Medical School, Boston, 
      Massachusetts, USA. msolomon@edc.org
FAU - Browning, David M
AU  - Browning DM
FAU - Dokken, Deborah L
AU  - Dokken DL
FAU - Merriman, Melanie P
AU  - Merriman MP
FAU - Rushton, Cynda H
AU  - Rushton CH
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Arch Pediatr Adolesc Med
JT  - Archives of pediatrics & adolescent medicine
JID - 9422751
SB  - IM
CIN - Arch Pediatr Adolesc Med. 2010 Apr;164(4):389-90. PMID: 20368494
MH  - Canada
MH  - Child
MH  - Curriculum
MH  - Education, Continuing/*methods
MH  - Humans
MH  - Interdisciplinary Communication
MH  - Models, Educational
MH  - *Palliative Care
MH  - Patient Advocacy
MH  - Pediatrics/*education
MH  - *Professional-Family Relations
MH  - Program Evaluation
MH  - *Quality of Health Care
MH  - United States
EDAT- 2010/04/07 06:00
MHDA- 2010/04/20 06:00
CRDT- 2010/04/07 06:00
PHST- 2010/04/07 06:00 [entrez]
PHST- 2010/04/07 06:00 [pubmed]
PHST- 2010/04/20 06:00 [medline]
AID - 164/4/315 [pii]
AID - 10.1001/archpediatrics.2010.12 [doi]
PST - ppublish
SO  - Arch Pediatr Adolesc Med. 2010 Apr;164(4):315-22. doi:
      10.1001/archpediatrics.2010.12.


PMID- 20368146
OWN - NLM
STAT- MEDLINE
DCOM- 20100625
LR  - 20131121
IS  - 1544-3450 (Electronic)
IS  - 1086-5802 (Linking)
VI  - 50
IP  - 1
DP  - 2010 Jan-Feb
TI  - Pharmacogenomics: bridging the gap between science and practice.
PG  - e1-14; quiz e15-7
LID - 10.1331/JAPhA.2010.09124 [doi]
AB  - OBJECTIVE: To educate pharmacists about principles and concepts in
      pharmacogenomics, clinical applications of pharmacogenomic information, and the
      social, ethical, and legal aspects of pharmacogenomics and to describe a Centers 
      for Disease Control and Prevention (CDC)-supported pharmacogenomics education
      program for pharmacists and other health professionals. DATA SOURCES: Primary
      literature from PubMed, recommendations from the Food and Drug Administration and
      Evaluation of Genomic Applications in Practice and Prevention Working Group,
      prescribing information, websites of government agencies and professional
      organizations, and relevant textbooks. STUDY SELECTION: Not applicable. DATA
      EXTRACTION: Not applicable. DATA SYNTHESIS: Principles and concepts of
      pharmacogenomic nomenclature, polymorphism types, and systematic approach to
      understanding polymorphisms were reviewed. Drug therapy for select therapeutic
      areas that highlight the applicability of pharmacogenomics are presented,
      including abacavir, selective serotonin reuptake inhibitors, tamoxifen, and
      warfarin. Challenges of translating pharmacogenomics into clinical practice
      included ethical, social, legal, and economic issues. We have developed a
      pharmacogenomics education program to disseminate evidence-based pharmacogenomics
      information and provide a resource for health professionals, including
      pharmacists. CONCLUSION: Pharmacists play a critical role in the education of
      patients and health professionals in the area of pharmacogenomics.
FAU - Lee, Kelly C
AU  - Lee KC
AD  - Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, 
      San Diego, La Jolla, CA 92093-0714, USA. kellylee@ucsd.edu
FAU - Ma, Joseph D
AU  - Ma JD
FAU - Kuo, Grace M
AU  - Kuo GM
LA  - eng
GR  - 1U38GD000070/GD/OGDP CDC HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - J Am Pharm Assoc (2003)
JT  - Journal of the American Pharmacists Association : JAPhA
JID - 101176252
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Drug Therapy/methods
MH  - Drug-Related Side Effects and Adverse Reactions
MH  - Education, Pharmacy, Continuing
MH  - Evidence-Based Medicine
MH  - Genetic Testing
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Patient Education as Topic
MH  - Pharmaceutical Preparations/administration & dosage/metabolism
MH  - Pharmaceutical Services/organization & administration/*standards/trends
MH  - Pharmacogenetics/economics/*education/ethics/legislation & jurisprudence/trends
MH  - Polymorphism, Genetic
MH  - Social Justice
MH  - United States
RF  - 104
EDAT- 2010/04/07 06:00
MHDA- 2010/06/26 06:00
CRDT- 2010/04/07 06:00
PHST- 2010/04/07 06:00 [entrez]
PHST- 2010/04/07 06:00 [pubmed]
PHST- 2010/06/26 06:00 [medline]
AID - S1544-3191(15)30769-X [pii]
AID - 10.1331/JAPhA.2010.09124 [doi]
PST - ppublish
SO  - J Am Pharm Assoc (2003). 2010 Jan-Feb;50(1):e1-14; quiz e15-7. doi:
      10.1331/JAPhA.2010.09124.


PMID- 20367868
OWN - NLM
STAT- MEDLINE
DCOM- 20100729
LR  - 20181201
IS  - 1365-2753 (Electronic)
IS  - 1356-1294 (Linking)
VI  - 16
IP  - 2
DP  - 2010 Apr
TI  - Prudent evidence-fettered shared decision making.
PG  - 376-81
LID - 10.1111/j.1365-2753.2010.01403.x [doi]
AB  - In its brief tenure evidence-based medicine (EBM) has proven to be a powerful
      magnet for criticism, while at the same time it has demonstrated impressive
      resilience. Located within the ongoing critical discourse surrounding the
      strengths and weaknesses of an EBM approach is the persistent question of the
      proper place of the social sciences relative to other disciplinary perspectives. 
      This article considers one way the social sciences might usefully illuminate
      EBM-mediated human interactions to influence policy. We focus on the ethical
      nexus of the human impulse for unlimited consumption of health care resources in 
      those situations where there exist competing clinical management options and
      suggest strategies for resource-preserving shared decision making. We conclude
      that a frugal default option is a fruitful avenue for future exploration in such 
      situations.
FAU - Bogdan-Lovis, Elizabeth Libby
AU  - Bogdan-Lovis EL
AD  - Center for Ethics and Humanities in the Life Sciences, Michigan State University,
      East Lansing, Michigan 48824, USA. libby.bogdan@ht.msu.edu
FAU - Holmes-Rovner, Margaret
AU  - Holmes-Rovner M
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Eval Clin Pract
JT  - Journal of evaluation in clinical practice
JID - 9609066
SB  - IM
CIN - J Eval Clin Pract. 2010 Apr;16(2):382-3. PMID: 20367869
MH  - Behavior
MH  - *Decision Making
MH  - *Evidence-Based Medicine
MH  - Health Resources/statistics & numerical data
MH  - Humans
MH  - *Patient Participation
MH  - Personal Autonomy
MH  - Primary Health Care
MH  - Social Sciences
EDAT- 2010/04/07 06:00
MHDA- 2010/07/30 06:00
CRDT- 2010/04/07 06:00
PHST- 2010/04/07 06:00 [entrez]
PHST- 2010/04/07 06:00 [pubmed]
PHST- 2010/07/30 06:00 [medline]
AID - JEP1403 [pii]
AID - 10.1111/j.1365-2753.2010.01403.x [doi]
PST - ppublish
SO  - J Eval Clin Pract. 2010 Apr;16(2):376-81. doi: 10.1111/j.1365-2753.2010.01403.x.


PMID- 20367867
OWN - NLM
STAT- MEDLINE
DCOM- 20100729
LR  - 20100406
IS  - 1365-2753 (Electronic)
IS  - 1356-1294 (Linking)
VI  - 16
IP  - 2
DP  - 2010 Apr
TI  - From evidence-based care to the standard of care. Commentary on Kerridge (2009)
      Ethics and EBM: acknowledging difference, accepting difference, and embracing
      politics.
PG  - 374-5
LID - 10.1111/j.1365-2753.2010.01402.x [doi]
FAU - Gupta, Mona
AU  - Gupta M
AD  - Department of Psychiatry, Women's College Hospital & University of Toronto,
      Toronto, Ontario, Canada.
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - England
TA  - J Eval Clin Pract
JT  - Journal of evaluation in clinical practice
JID - 9609066
SB  - IM
CON - J Eval Clin Pract. 2010 Apr;16(2):365-73. PMID: 20367866
MH  - Delivery of Health Care/*standards
MH  - Evidence-Based Medicine/*ethics
MH  - Humans
MH  - *Politics
EDAT- 2010/04/07 06:00
MHDA- 2010/07/30 06:00
CRDT- 2010/04/07 06:00
PHST- 2010/04/07 06:00 [entrez]
PHST- 2010/04/07 06:00 [pubmed]
PHST- 2010/07/30 06:00 [medline]
AID - JEP1402 [pii]
AID - 10.1111/j.1365-2753.2010.01402.x [doi]
PST - ppublish
SO  - J Eval Clin Pract. 2010 Apr;16(2):374-5. doi: 10.1111/j.1365-2753.2010.01402.x.


PMID- 20367866
OWN - NLM
STAT- MEDLINE
DCOM- 20100729
LR  - 20171116
IS  - 1365-2753 (Electronic)
IS  - 1356-1294 (Linking)
VI  - 16
IP  - 2
DP  - 2010 Apr
TI  - Ethics and EBM: acknowledging bias, accepting difference and embracing politics.
PG  - 365-73
LID - 10.1111/j.1365-2753.2010.01412.x [doi]
AB  - Evidence-based medicine (EBM) has been effective because it confers both
      epistemic and moral authority, promising that both individual patient care and
      public health interventions are effective, safe and efficient, that these
      decisions and standards can be determined (and therefore judged) in a transparent
      manner and that this form of decision making is reliable, objective and
      value-free. The problem is that EBM refers to particular, ideologically and
      philosophically specific concepts of evidence, medicine and the relationship
      between them. The analysis of the 'ethics' of EBM, therefore, requires not only a
      critique of its philosophical naivety and its attachment to modernism and
      positivism, but a critique of its social, cultural and political implications.
FAU - Kerridge, Ian
AU  - Kerridge I
AD  - Centre for Values, Ethics and the Law in Medicine, University of Sydney, Sydney, 
      New South Wales, Australia. kerridge@med.usyd.edu.au
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Eval Clin Pract
JT  - Journal of evaluation in clinical practice
JID - 9609066
SB  - IM
CIN - J Eval Clin Pract. 2010 Apr;16(2):374-5. PMID: 20367867
MH  - *Bias
MH  - Evidence-Based Medicine/*ethics
MH  - Humans
MH  - *Politics
EDAT- 2010/04/07 06:00
MHDA- 2010/07/30 06:00
CRDT- 2010/04/07 06:00
PHST- 2010/04/07 06:00 [entrez]
PHST- 2010/04/07 06:00 [pubmed]
PHST- 2010/07/30 06:00 [medline]
AID - JEP1412 [pii]
AID - 10.1111/j.1365-2753.2010.01412.x [doi]
PST - ppublish
SO  - J Eval Clin Pract. 2010 Apr;16(2):365-73. doi: 10.1111/j.1365-2753.2010.01412.x.


PMID- 20367863
OWN - NLM
STAT- MEDLINE
DCOM- 20100729
LR  - 20131121
IS  - 1365-2753 (Electronic)
IS  - 1356-1294 (Linking)
VI  - 16
IP  - 2
DP  - 2010 Apr
TI  - The politics of professional ethics.
PG  - 351-5
LID - 10.1111/j.1365-2753.2010.01399.x [doi]
AB  - In order to illustrate how terms of reference themselves, such as those announced
      by 'professional ethics', delimit and distort moral consideration I start with an
      extended discussion of how Just War Theory operates to do this; and go on to
      discuss 'the power of naming' with reference to the British attack on Iraq.
      Having thus situated my approach to the politics of professional ethics in a
      broader political context I offer a critique of 'professional' ethics in terms of
      what is left out of the moral picture and how in particular political
      considerations are sidelined. Finally I argue that 'codes' of professional ethics
      are especially insidious.
FAU - Brecher, Bob
AU  - Brecher B
AD  - Centre for Applied Philosophy, Politics and Ethics (CAPPE), University of
      Brighton, Brighton, UK. r.brecher@bton.ac.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Eval Clin Pract
JT  - Journal of evaluation in clinical practice
JID - 9609066
SB  - IM
MH  - *Codes of Ethics
MH  - Humans
MH  - Iraq War, 2003-2011
MH  - *Politics
EDAT- 2010/04/07 06:00
MHDA- 2010/07/30 06:00
CRDT- 2010/04/07 06:00
PHST- 2010/04/07 06:00 [entrez]
PHST- 2010/04/07 06:00 [pubmed]
PHST- 2010/07/30 06:00 [medline]
AID - JEP1399 [pii]
AID - 10.1111/j.1365-2753.2010.01399.x [doi]
PST - ppublish
SO  - J Eval Clin Pract. 2010 Apr;16(2):351-5. doi: 10.1111/j.1365-2753.2010.01399.x.


PMID- 20367857
OWN - NLM
STAT- MEDLINE
DCOM- 20100729
LR  - 20100406
IS  - 1365-2753 (Electronic)
IS  - 1356-1294 (Linking)
VI  - 16
IP  - 2
DP  - 2010 Apr
TI  - The concept of health: beyond normativism and naturalism.
PG  - 323-9
LID - 10.1111/j.1365-2753.2010.01393.x [doi]
AB  - Philosophical discussions of health and disease have traditionally been dominated
      by a debate between normativists, who hold that health is an inescapably
      value-laded concept and naturalists, such as Christopher Boorse, who believe that
      it is possible to derive a purely descriptive or theoretical definition of health
      based upon biological function. In this paper I defend a distinctive view which
      traces its origins in Aristotle's naturalistic ethics. An Arisotelian would agree
      with Boorse that health and disease are ubiquitous features of the natural world 
      and thus not mere projections of human interests and values. She would differ
      from him in rejecting the idea that value is a non-natural quality. I conclude my
      discussion with some comments of the normative character of living systems.
FAU - Hamilton, Richard P
AU  - Hamilton RP
AD  - School of Philosophy and Theology, School of Medicine, University of Notre Dame
      Australia, Fremantle, Western Australia, Australia. rhamilton@nd.edu.au
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Eval Clin Pract
JT  - Journal of evaluation in clinical practice
JID - 9609066
SB  - IM
MH  - *Health
MH  - Humans
MH  - Models, Theoretical
MH  - *Philosophy, Medical
EDAT- 2010/04/07 06:00
MHDA- 2010/07/30 06:00
CRDT- 2010/04/07 06:00
PHST- 2010/04/07 06:00 [entrez]
PHST- 2010/04/07 06:00 [pubmed]
PHST- 2010/07/30 06:00 [medline]
AID - JEP1393 [pii]
AID - 10.1111/j.1365-2753.2010.01393.x [doi]
PST - ppublish
SO  - J Eval Clin Pract. 2010 Apr;16(2):323-9. doi: 10.1111/j.1365-2753.2010.01393.x.


PMID- 20367853
OWN - NLM
STAT- MEDLINE
DCOM- 20100729
LR  - 20111031
IS  - 1365-2753 (Electronic)
IS  - 1356-1294 (Linking)
VI  - 16
IP  - 2
DP  - 2010 Apr
TI  - From Popperian science to normal science. Commentary on Sestini (2009)
      'Epistemology and ethics of evidence-based medicine'.
PG  - 306-9
LID - 10.1111/j.1365-2753.2010.01389.x [doi]
FAU - Goldenberg, Maya J
AU  - Goldenberg MJ
AD  - Assistant Professor, Department of Philosophy, University of Guelph, Guelph,
      Ontario, Canada.
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - England
TA  - J Eval Clin Pract
JT  - Journal of evaluation in clinical practice
JID - 9609066
SB  - IM
CON - J Eval Clin Pract. 2010 Apr;16(2):301-5. PMID: 20367852
CIN - J Eval Clin Pract. 2011 Oct;17(5):1002-3; discussion 1004-5. PMID: 21951935
MH  - Evidence-Based Medicine/*ethics
MH  - Humans
MH  - *Knowledge
MH  - *Philosophy, Medical
EDAT- 2010/04/07 06:00
MHDA- 2010/07/30 06:00
CRDT- 2010/04/07 06:00
PHST- 2010/04/07 06:00 [entrez]
PHST- 2010/04/07 06:00 [pubmed]
PHST- 2010/07/30 06:00 [medline]
AID - JEP1389 [pii]
AID - 10.1111/j.1365-2753.2010.01389.x [doi]
PST - ppublish
SO  - J Eval Clin Pract. 2010 Apr;16(2):306-9. doi: 10.1111/j.1365-2753.2010.01389.x.


PMID- 20367852
OWN - NLM
STAT- MEDLINE
DCOM- 20100729
LR  - 20100406
IS  - 1365-2753 (Electronic)
IS  - 1356-1294 (Linking)
VI  - 16
IP  - 2
DP  - 2010 Apr
TI  - Epistemology and ethics of evidence-based medicine: putting goal-setting in the
      right place.
PG  - 301-5
LID - 10.1111/j.1365-2753.2009.01327.x [doi]
AB  - While evidence-based medicine (EBM) is often accused on relying on a paradigm of 
      'absolute truth', it is in fact highly consistent with Karl Popper's criterion of
      demarcation through falsification. Even more relevant, the first three steps of
      the EBM process are closely patterned on Popper's evolutionary approach of
      objective knowledge: (1) recognition of a problem; (2) generation of solutions;
      and (3) selection of the best solution. This places the step 1 of the EBM process
      (building an answerable question) in a pivotal position for the understanding of 
      the whole process, and underscores a few aspects which are often overlooked in
      EBM courses. First in this step internal evidence (including personal expertise) 
      must be appraised and integrated in the problem. Second, issues of applicability 
      of the possible solution should be anticipated. Third, and possibly more
      important, the goal of the intervention should be set at this stage (typically by
      choosing the outcome in a PICO question). Depending whether or not goals depend
      on the goals of others, and whether they concern others' voluntary behaviour,
      goals may be classified as self-serving, moral, altruistic or moralistic. Thus,
      delicate ethical questions must be addressed at this stage, which means that
      patient preferences and values must be carefully sought, so that empathy,
      counselling and narrative medicine must be mastered to be able to formulate
      correctly an answerable question. The need to modify the current description of
      the EBM process to increase the recognition of implicit assumptions and increase 
      the consistency of this model is discussed.
FAU - Sestini, Piersante
AU  - Sestini P
AD  - Department of Clinical Medicine and Immulological Sciences, Section of
      Respiratory Diseases, University of Siena, Siena, Italy. sestini@unisi.it
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Eval Clin Pract
JT  - Journal of evaluation in clinical practice
JID - 9609066
SB  - IM
CIN - J Eval Clin Pract. 2010 Apr;16(2):306-9. PMID: 20367853
MH  - Education, Medical
MH  - Evidence-Based Medicine/*ethics
MH  - *Goals
MH  - Humans
MH  - *Knowledge
EDAT- 2010/04/07 06:00
MHDA- 2010/07/30 06:00
CRDT- 2010/04/07 06:00
PHST- 2010/04/07 06:00 [entrez]
PHST- 2010/04/07 06:00 [pubmed]
PHST- 2010/07/30 06:00 [medline]
AID - JEP1327 [pii]
AID - 10.1111/j.1365-2753.2009.01327.x [doi]
PST - ppublish
SO  - J Eval Clin Pract. 2010 Apr;16(2):301-5. doi: 10.1111/j.1365-2753.2009.01327.x.


PMID- 20367844
OWN - NLM
STAT- MEDLINE
DCOM- 20100729
LR  - 20151119
IS  - 1365-2753 (Electronic)
IS  - 1356-1294 (Linking)
VI  - 16
IP  - 2
DP  - 2010 Apr
TI  - Philosophy, ethics, medicine and health care: the urgent need for critical
      practice.
PG  - 249-59
LID - 10.1111/j.1365-2753.2010.01411.x [doi]
FAU - Loughlin, Michael
AU  - Loughlin M
FAU - Upshur, Ross E G
AU  - Upshur RE
FAU - Goldenberg, Maya J
AU  - Goldenberg MJ
FAU - Bluhm, Robyn
AU  - Bluhm R
FAU - Borgerson, Kirstin
AU  - Borgerson K
LA  - eng
PT  - Editorial
PL  - England
TA  - J Eval Clin Pract
JT  - Journal of evaluation in clinical practice
JID - 9609066
SB  - IM
MH  - Congresses as Topic
MH  - Delivery of Health Care/*ethics
MH  - Education
MH  - Evidence-Based Medicine
MH  - Humans
MH  - *Philosophy, Medical
MH  - *Practice Patterns, Physicians'
EDAT- 2010/04/07 06:00
MHDA- 2010/07/30 06:00
CRDT- 2010/04/07 06:00
PHST- 2010/04/07 06:00 [entrez]
PHST- 2010/04/07 06:00 [pubmed]
PHST- 2010/07/30 06:00 [medline]
AID - JEP1411 [pii]
AID - 10.1111/j.1365-2753.2010.01411.x [doi]
PST - ppublish
SO  - J Eval Clin Pract. 2010 Apr;16(2):249-59. doi: 10.1111/j.1365-2753.2010.01411.x.


PMID- 20367507
OWN - NLM
STAT- MEDLINE
DCOM- 20100629
LR  - 20140723
IS  - 1525-6065 (Electronic)
IS  - 1064-1955 (Linking)
VI  - 29
IP  - 2
DP  - 2010 Jan
TI  - Accuracy assessment of the Dinamap ProCare 400 in pregnancy and preeclampsia.
PG  - 198-205
LID - 10.3109/10641950902968650 [doi]
AB  - OBJECTIVE: To assess the accuracy of the Dinamap ProCare 400 in pregnancy and
      preeclampsia, according to the British Hypertension Society protocol. METHODS:
      Ethical approval was obtained. Forty-five women were recruited at two large
      teaching hospitals. Nine sequential same arm measurements were taken from each
      woman alternating between the Dinamap and mercury sphygmomanometry. RESULTS: The 
      device achieved an A/A grade (pregnancy) and an A/B grade (preeclampsia). Mean
      difference (SD) were 1.1(5.8)/0.1(5.7) mmHg (pregnancy) and -0.5(5.4)/0.9(9.5)
      mmHg (preeclampsia) for systolic/diastolic. CONCLUSION: The Dinamap ProCare 400
      is recommended for use in pregnancy and has good accuracy in preeclampsia,
      although caution is still advised.
FAU - De Greeff, Annemarie
AU  - De Greeff A
AD  - King's College London, Division of Reproduction and Endocrinology, St. Thomas'
      Hospital, London, United Kingdom.
FAU - Ghosh, Donna
AU  - Ghosh D
FAU - Anthony, John
AU  - Anthony J
FAU - Shennan, Andrew
AU  - Shennan A
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - England
TA  - Hypertens Pregnancy
JT  - Hypertension in pregnancy
JID - 9421297
SB  - IM
MH  - Adult
MH  - Blood Pressure Determination/*instrumentation
MH  - Female
MH  - Humans
MH  - Pre-Eclampsia/*diagnosis
MH  - Pregnancy
EDAT- 2010/04/07 06:00
MHDA- 2010/06/30 06:00
CRDT- 2010/04/07 06:00
PHST- 2010/04/07 06:00 [entrez]
PHST- 2010/04/07 06:00 [pubmed]
PHST- 2010/06/30 06:00 [medline]
AID - 10.3109/10641950902968650 [doi]
PST - ppublish
SO  - Hypertens Pregnancy. 2010 Jan;29(2):198-205. doi: 10.3109/10641950902968650.


PMID- 20364529
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20211020
IS  - 0008-4263 (Print)
IS  - 0008-4263 (Linking)
VI  - 101
IP  - 1
DP  - 2010 Jan-Feb
TI  - Re-visioning public health ethics: a relational perspective.
PG  - 9-11
AB  - Canada is in the forefront of thinking about the unique and complex issues of
      contemporary public health ethics. However, an inordinate focus on the urgent
      issues of emergency preparedness in pandemic and reliance on bioethical analysis 
      steeped in the autonomy and individual rights tradition of health care and
      research do not serve adequately as the basis for an ethic of public health with 
      its focus on populations, communities and the common good. This paper describes
      some concerns regarding the focus on pandemic ethics in isolation from public
      health ethics; identifies inadequacies in the dominant individualistic ethics
      framework; and summarizes nascent work on the concepts of relational autonomy,
      relational social justice and relational solidarity that can inform a
      re-visioning of public health ethics. While there is still much work to be done
      to further refine these principles, they can help to reclaim and centre the
      common and collective good at risk in pandemic and other emergency situations.
      Minimally, these principles require a policy-making process that is truly
      transparent, fair and inclusive; is sensitive and responsive to the workings of
      systemic inequalities; and requires public recognition of the fact that we enter 
      any crisis with varying degrees of inequity. Public policy response to crisis
      must not forseeably increase existing inequities.
FAU - Kenny, Nuala P
AU  - Kenny NP
AD  - Department of Bioethics, Dalhousie University, 5849 University Avenue, Halifax,
      NS B3H 4H7. nuala.kenny@dal.ca
FAU - Sherwin, Susan B
AU  - Sherwin SB
FAU - Baylis, Francoise E
AU  - Baylis FE
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Can J Public Health
JT  - Canadian journal of public health = Revue canadienne de sante publique
JID - 0372714
SB  - IM
MH  - Canada
MH  - *Communication
MH  - Health Policy
MH  - Health Status Disparities
MH  - Humans
MH  - Public Health/*ethics
MH  - Public Health Practice/ethics
MH  - *Social Justice
PMC - PMC6974005
EDAT- 2010/04/07 06:00
MHDA- 2011/01/07 06:00
CRDT- 2010/04/07 06:00
PHST- 2010/04/07 06:00 [entrez]
PHST- 2010/04/07 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
PST - ppublish
SO  - Can J Public Health. 2010 Jan-Feb;101(1):9-11.


PMID- 20364522
OWN - NLM
STAT- MEDLINE
DCOM- 20100503
LR  - 20190923
IS  - 0743-2550 (Print)
IS  - 0743-2550 (Linking)
VI  - 27
IP  - 2
DP  - 2010 Apr-Jun
TI  - Promoting ethical development in nursing education and beyond.
PG  - 96-9
AB  - Ethical nursing practice can be referred to as doing what is best for those who
      are the recipient of one's services, according to the recipient. However,
      clear-cut lines of what is and is not in the best interest of the patient can
      become blurred. Nurses often encounter situations that require them to use
      ethical judgment. This article discusses how ethical decision making can be
      developed in students, new graduates, and nurses in practice.
FAU - Stagg, Denise
AU  - Stagg D
AD  - University of Louisiana, Lafayette, USA.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Christ Nurs
JT  - Journal of Christian nursing : a quarterly publication of Nurses Christian
      Fellowship
JID - 8411743
MH  - Decision Making/ethics
MH  - Education, Nursing, Baccalaureate/ethics
MH  - Ethics, Nursing/education
MH  - Female
MH  - Humans
MH  - Morale
MH  - Morals
MH  - Nurse's Role/*psychology
MH  - Nursing Assessment/ethics
MH  - Nursing Care/ethics
MH  - Nursing Staff, Hospital/education/*ethics
MH  - *Physician-Nurse Relations
MH  - Problem Solving/ethics
MH  - Professional Practice/*ethics
MH  - *Self Efficacy
MH  - Young Adult
EDAT- 2010/04/07 06:00
MHDA- 2010/05/04 06:00
CRDT- 2010/04/07 06:00
PHST- 2010/04/07 06:00 [entrez]
PHST- 2010/04/07 06:00 [pubmed]
PHST- 2010/05/04 06:00 [medline]
AID - 10.1097/cnj.0b013e3181d22fb6 [doi]
PST - ppublish
SO  - J Christ Nurs. 2010 Apr-Jun;27(2):96-9. doi: 10.1097/cnj.0b013e3181d22fb6.


PMID- 20364454
OWN - NLM
STAT- MEDLINE
DCOM- 20100617
LR  - 20191027
IS  - 1531-7013 (Electronic)
IS  - 1087-2418 (Linking)
VI  - 15
IP  - 2
DP  - 2010 Apr
TI  - Transplant tourism.
PG  - 245-8
AB  - PURPOSE OF REVIEW: Because of the ongoing organ donor shortage, transplant
      tourism is occurring at an increasing rate both in the USA and abroad. To date,
      there have been little published data to help guide the programmatic philosophy
      of the USA transplant centers regarding transplant tourism. RECENT FINDINGS: We
      summarize position statements from several transplant societies regarding
      transplant tourism and specifically transplantation occurring in China (because
      of the use of executed prisoners as organ donors). Transplant tourism is ever
      increasing and patients may be at risk for greater post-transplant morbidity as
      well as inadequate follow up care. Transplant centers require some guidance with 
      regard of how to deal with these patients. SUMMARY: Transplant tourism is an
      increasing reality facing the USA transplant centers. Most professional societies
      do not condone it yet cannot abrogate a physician's right to care for such
      patients. Ethical principles mandate transplant physicians provide adequate care 
      for returning transplant tourists. Better ways of assessing the scope of the
      problem are necessary. Transplant tourism may exist because of the disparity
      between the need for organ donors and their availability and is thus is likely to
      continue into the future.
FAU - Schiano, Thomas D
AU  - Schiano TD
AD  - Division of Liver Diseases, The Mount Sinai School of Medicine, New York, New
      York 10029, USA. Thomas.Schiano@mountsinai.org
FAU - Rhodes, Rosamond
AU  - Rhodes R
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Organ Transplant
JT  - Current opinion in organ transplantation
JID - 9717388
SB  - IM
MH  - Attitude of Health Personnel
MH  - China
MH  - Health Knowledge, Attitudes, Practice
MH  - Health Services Accessibility
MH  - Humans
MH  - *Medical Tourism/ethics/psychology
MH  - *Organ Transplantation/adverse effects/ethics/psychology
MH  - Patient Education as Topic
MH  - Practice Guidelines as Topic
MH  - Public Opinion
MH  - Risk Assessment
MH  - Tissue Donors/ethics/psychology/*supply & distribution
MH  - United States
RF  - 26
EDAT- 2010/04/07 06:00
MHDA- 2010/06/18 06:00
CRDT- 2010/04/06 06:00
PHST- 2010/04/06 06:00 [entrez]
PHST- 2010/04/07 06:00 [pubmed]
PHST- 2010/06/18 06:00 [medline]
AID - 10.1097/mot.0b013e328337353e [doi]
PST - ppublish
SO  - Curr Opin Organ Transplant. 2010 Apr;15(2):245-8. doi:
      10.1097/mot.0b013e328337353e.


PMID- 20364092
OWN - NLM
STAT- MEDLINE
DCOM- 20100421
LR  - 20211020
IS  - 1558-8238 (Electronic)
IS  - 0021-9738 (Linking)
VI  - 120
IP  - 4
DP  - 2010 Apr
TI  - How we are born.
PG  - 952-5
LID - 10.1172/JCI42380 [doi]
LID - 42380 [pii]
AB  - Human reproduction is relatively inefficient. Nearly 30% of pregnancies result in
      spontaneous losses, which are both a clinical problem and a psychological stress 
      to the families involved. Furthermore, although the human population is growing
      rapidly and is predicted to reach 9 billion by 2050, 15% of couples worldwide are
      childless because of infertility. Many underlying causes of infertility have been
      overcome by assisted reproductive technologies such as in vitro fertilization,
      yet pregnancy success rates using such approaches remain disappointingly low.
      Since mechanistic approaches to study human reproductive processes are ethically 
      restricted, future advances in fertility treatment and the development of new
      contraceptives rely predominantly on the study of the factors influencing
      reproduction in model systems. The articles in this Reproductive Biology Review
      series present updates on the current understanding of various reproductive
      processes in model systems and raise questions that need to be addressed if we
      are to improve human reproductive health.
FAU - Dey, Sudhansu K
AU  - Dey SK
AD  - Cincinnati Children's Research Foundation, Division of Reproductive Sciences, MLC
      7045, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA. sk.dey@cchmc.org
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100401
PL  - United States
TA  - J Clin Invest
JT  - The Journal of clinical investigation
JID - 7802877
SB  - IM
MH  - Animals
MH  - Embryo Implantation
MH  - Female
MH  - Humans
MH  - Male
MH  - Placenta/physiology
MH  - Pregnancy
MH  - Reproduction/*physiology
MH  - Sperm-Ovum Interactions
RF  - 16
PMC - PMC2846070
EDAT- 2010/04/07 06:00
MHDA- 2010/04/22 06:00
CRDT- 2010/04/06 06:00
PHST- 2010/04/06 06:00 [entrez]
PHST- 2010/04/07 06:00 [pubmed]
PHST- 2010/04/22 06:00 [medline]
AID - 42380 [pii]
AID - 10.1172/JCI42380 [doi]
PST - ppublish
SO  - J Clin Invest. 2010 Apr;120(4):952-5. doi: 10.1172/JCI42380. Epub 2010 Apr 1.


PMID- 20362725
OWN - NLM
STAT- MEDLINE
DCOM- 20100513
LR  - 20211020
IS  - 1097-6744 (Electronic)
IS  - 0002-8703 (Linking)
VI  - 159
IP  - 4
DP  - 2010 Apr
TI  - Diagnostic and prognostic utility of electrocardiography for left ventricular
      hypertrophy defined by magnetic resonance imaging in relationship to ethnicity:
      the Multi-Ethnic Study of Atherosclerosis (MESA).
PG  - 652-8
LID - 10.1016/j.ahj.2009.12.035 [doi]
AB  - BACKGROUND: Left ventricular mass is a strong predictor of cardiovascular disease
      (CVD), and magnetic resonance imaging (MRI) of the heart is a standard of
      reference for left ventricular mass measurement. Ethnicity is believed to affect 
      electrocardiographic (ECG) performance. We evaluated the diagnostic and
      prognostic performance of ECG for left ventricular hypertrophy (LVH) as defined
      by MRI in relationship to ethnicity. METHODS: Data were analyzed from 4,967
      participants (48% men, mean age 62 +/- 10 years; 39% white, 13% Chinese, 26%
      African American, 22% Hispanic) enrolled in the Multi-Ethic Study of
      Atherosclerosis (MESA) who were followed for a median of 4.8 years for incident
      CVD. RESULTS: Thirteen traditional ECG-LVH criteria were assessed, and showed
      overall and ethnicity-specific low sensitivity (10%-26%) and high specificity
      (88%-99%) in diagnosing MRI-defined LVH. Ten of 13 ECG-LVH criteria showed
      superior sensitivity and diagnostic performance in African Americans as compared 
      with whites (P = .02-.001). The sum of amplitudes of S wave in V(1), S wave in
      V(2), and R wave in V(5) (a MESA-specific ECG-LVH criterion) offered higher
      sensitivity (40.4%) compared with prior ECG-LVH criteria while maintaining good
      specificity (90%) and diagnostic performance (receiver operating characteristic
      area = 0.65). In fully adjusted models, only the MESA-specific ECG-LVH criterion,
      Romhilt-Estes score, Framingham score, Cornell voltage, Cornell duration product,
      and Framingham-adjusted Cornell voltage predicted increased CVD risk (P < .05).
      CONCLUSIONS: Electrocardiography has low sensitivity but high specificity for
      detecting MRI-defined LVH. The performance of ECG for LVH detection varies by
      ethnicity, with African Americans showing higher sensitivity and overall
      performance compared with other ethnic groups.
CI  - Copyright 2010 Mosby, Inc. All rights reserved.
FAU - Jain, Aditya
AU  - Jain A
AD  - Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, 
      MD, USA.
FAU - Tandri, Harikrishna
AU  - Tandri H
FAU - Dalal, Darshan
AU  - Dalal D
FAU - Chahal, Harjit
AU  - Chahal H
FAU - Soliman, Elsayed Z
AU  - Soliman EZ
FAU - Prineas, Ronald J
AU  - Prineas RJ
FAU - Folsom, Aaron R
AU  - Folsom AR
FAU - Lima, Joao A C
AU  - Lima JA
FAU - Bluemke, David A
AU  - Bluemke DA
LA  - eng
GR  - ZIA CL090019-01/ImNIH/Intramural NIH HHS/United States
GR  - N01 HC095167/HC/NHLBI NIH HHS/United States
GR  - N01 HC095161/HC/NHLBI NIH HHS/United States
GR  - N01 HC095164/HC/NHLBI NIH HHS/United States
GR  - ZIA EB000072-01/ImNIH/Intramural NIH HHS/United States
GR  - N01 HC095169/HC/NHLBI NIH HHS/United States
GR  - N01 HC095168/HC/NHLBI NIH HHS/United States
GR  - N01 HC095163/HC/NHLBI NIH HHS/United States
GR  - N01 HC095162/HC/NHLBI NIH HHS/United States
GR  - N01 HC095159/HC/NHLBI NIH HHS/United States
GR  - N01 HC095166/HC/NHLBI NIH HHS/United States
GR  - N01 HC095160/HC/NHLBI NIH HHS/United States
GR  - Z99 CL999999/ImNIH/Intramural NIH HHS/United States
GR  - N01 HC095165/HC/NHLBI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Am Heart J
JT  - American heart journal
JID - 0370465
SB  - IM
MH  - Aged
MH  - Electrocardiography
MH  - Female
MH  - Humans
MH  - Hypertrophy, Left Ventricular/*diagnosis/*ethnology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Sensitivity and Specificity
PMC - PMC2856691
MID - NIHMS172791
EDAT- 2010/04/07 06:00
MHDA- 2010/05/14 06:00
CRDT- 2010/04/06 06:00
PHST- 2009/09/25 00:00 [received]
PHST- 2009/12/14 00:00 [accepted]
PHST- 2010/04/06 06:00 [entrez]
PHST- 2010/04/07 06:00 [pubmed]
PHST- 2010/05/14 06:00 [medline]
AID - S0002-8703(10)00076-1 [pii]
AID - 10.1016/j.ahj.2009.12.035 [doi]
PST - ppublish
SO  - Am Heart J. 2010 Apr;159(4):652-8. doi: 10.1016/j.ahj.2009.12.035.


PMID- 20362696
OWN - NLM
STAT- MEDLINE
DCOM- 20110126
LR  - 20220309
IS  - 1872-9649 (Electronic)
IS  - 1568-1637 (Linking)
VI  - 9
IP  - 3
DP  - 2010 Jul
TI  - How far are induced pluripotent stem cells from the clinic?
PG  - 257-64
LID - 10.1016/j.arr.2010.03.001 [doi]
AB  - Induced pluripotent stem cells (iPSCs) can be derived from diverse different
      somatic cells and share many of the characteristics of embryonic stem cells
      (ESCs). Because iPSCs avoid many of the ethical concerns associated with the use 
      of embryonic or fetal material, iPSCs have great potential in cell-based
      regenerative medicine. However, several hurdles will need to be surmounted before
      their potential can be realized in therapeutic applications. For example, the use
      of viral vectors, some of which are oncogenes raises the risk of tumor formation 
      in patients, the differentiation of iPSCs into required functional cells in vivo 
      remains to be established, the obtaining of pure populations of target cells from
      iPSCs is still difficult. Of these, some are shared by both iPSCs and ESCs,
      others are unique to iPSCs. We will describe these stumbling blocks in detail and
      discuss possible ways to overcome them. Despite many significant advances, there 
      is as yet no technological framework that would allow the exploitation of iPSCs
      in a clinical setting in the immediate future. Further research will be required 
      before directed reprogramming can provide a source of cells suitable for
      application in regenerative medicine.
CI  - 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Li, Meirong
AU  - Li M
AD  - Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Science,
      Trauma Center of Postgraduate Medical School, Chinese PLA General Hospital, 28 Fu
      Xing Road, HaiDian District, Beijing 100853, PR China.
FAU - Chen, Meixia
AU  - Chen M
FAU - Han, Weidong
AU  - Han W
FAU - Fu, Xiaobing
AU  - Fu X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100401
PL  - England
TA  - Ageing Res Rev
JT  - Ageing research reviews
JID - 101128963
SB  - IM
MH  - Animals
MH  - Humans
MH  - Induced Pluripotent Stem Cells/cytology/*transplantation
MH  - Regenerative Medicine/methods/*trends
MH  - Stem Cell Transplantation/adverse effects/methods/*trends
RF  - 86
EDAT- 2010/04/07 06:00
MHDA- 2011/01/28 06:00
CRDT- 2010/04/06 06:00
PHST- 2010/01/20 00:00 [received]
PHST- 2010/03/17 00:00 [revised]
PHST- 2010/03/17 00:00 [accepted]
PHST- 2010/04/06 06:00 [entrez]
PHST- 2010/04/07 06:00 [pubmed]
PHST- 2011/01/28 06:00 [medline]
AID - S1568-1637(10)00023-1 [pii]
AID - 10.1016/j.arr.2010.03.001 [doi]
PST - ppublish
SO  - Ageing Res Rev. 2010 Jul;9(3):257-64. doi: 10.1016/j.arr.2010.03.001. Epub 2010
      Apr 1.


PMID- 20362406
OWN - NLM
STAT- MEDLINE
DCOM- 20101208
LR  - 20151119
IS  - 1872-6283 (Electronic)
IS  - 0379-0738 (Linking)
VI  - 201
IP  - 1-3
DP  - 2010 Sep 10
TI  - In the absence of dental records, do we need forensic odontologists at mass grave
      sites?
PG  - 22-6
LID - 10.1016/j.forsciint.2010.03.012 [doi]
AB  - With the exception of exhumations of mass graves in Latin America, forensic
      dentists and odontologists are rarely involved in the examination of mortal
      remains recovered from mass graves. The cited reason is often that "there are no 
      dental records-so what is the point"? In this presentation we review the
      published accounts of examination of remains arising from the conflict in the
      former Yugoslavia between 1991 and 1999 in which dental examinations are
      reported. There are roughly 30,000 missing persons of which more than 15,000
      mortal remains have been identified, mostly based on DNA. There are 9 sources
      which describe postmortem dental examinations of 3919 sets of remains; of these, 
      23% were purported to have been identified specifically from dental information. 
      Of the 8100 listed missing persons from the Srebrenica mass killings in 1995, we 
      located 600 dental records. A sample of 263 charts was examined for information
      about first molar treatment as we are concerned that dental charting of
      individuals who lose their first molars may be incorrectly done if allowance is
      not made for mesial drift of the remaining molars. We found that of all the first
      molar extractions that are ever going to occur according to these dental charts, 
      63% have taken place by age 18. The majority of extracted first molars have a
      functional age of 17 years. We observe that an adult's remains from Srebrenica
      usually have only second and third molars, which have often drifted forward to
      occupy the position of the first molar creating the appearance of third molar
      agenesis. We conclude: that, since dental identifications of victims in mass
      graves and mass disasters is the exception rather than the rule, even in the
      absence of DNA-based identifications, international forensic odontologists have
      an ethical obligation to become more involved in examination of mass grave
      victims, that there must be more determined searches for antemortem dental
      records; that local dentists should be approached to participate in the
      examination of remains and lastly that dental examination and charting by
      anthropologists and pathologists may be grossly inaccurate. Furthermore, even in 
      the absence of dental records, there is significant information about the
      individual to be obtained by an oral biologist since many families have useful
      memories about the oral status of their loved ones who went missing.
CI  - Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Skinner, Mark
AU  - Skinner M
AD  - Department of Archaeology, Simon Fraser University, Burnaby, B.C., V5A 1S6,
      Canada. mskinner@sfu.ca
FAU - Alempijevic, Djordje
AU  - Alempijevic D
FAU - Stanojevic, Aleksandar
AU  - Stanojevic A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100401
PL  - Ireland
TA  - Forensic Sci Int
JT  - Forensic science international
JID - 7902034
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Determination by Teeth/methods
MH  - Aged
MH  - *Burial
MH  - Child
MH  - Dental Records
MH  - Dentition
MH  - Female
MH  - *Forensic Dentistry
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Molar/pathology/surgery
MH  - Tooth Extraction
MH  - *Warfare
MH  - Young Adult
MH  - Yugoslavia
EDAT- 2010/04/07 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/04/06 06:00
PHST- 2010/01/09 00:00 [received]
PHST- 2010/03/06 00:00 [revised]
PHST- 2010/03/09 00:00 [accepted]
PHST- 2010/04/06 06:00 [entrez]
PHST- 2010/04/07 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S0379-0738(10)00104-0 [pii]
AID - 10.1016/j.forsciint.2010.03.012 [doi]
PST - ppublish
SO  - Forensic Sci Int. 2010 Sep 10;201(1-3):22-6. doi:
      10.1016/j.forsciint.2010.03.012. Epub 2010 Apr 1.


PMID- 20362381
OWN - NLM
STAT- MEDLINE
DCOM- 20100714
LR  - 20211020
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 70
IP  - 12
DP  - 2010 Jun
TI  - 'Like sugar and honey': the embedded ethics of a larval control project in The
      Gambia.
PG  - 1912-1919
LID - S0277-9536(10)00171-1 [pii]
LID - 10.1016/j.socscimed.2010.02.012 [doi]
AB  - This paper describes a malaria research project in The Gambia to provoke thinking
      on the social value of transnational research. The Larval Control Project (LCP)
      investigated the efficacy of a microbial insecticide to reduce vector density
      and, ultimately, clinical malaria in Gambian children. The LCP's protocol
      delineated a clinical surveillance scheme that involved Village Health Workers
      (VHWs) supported by project nurses. Combining insights from ethnographic
      fieldwork conducted at the Medical Research Council (MRC) Laboratories in
      Farafenni from 2005 to 2009, open-ended interviews with project nurses, and eight
      focus group discussions held with participant mothers in October 2007, we
      consider the social impact of the LCP's investigative method against the backdrop
      of several years of research activity. We found that while participants
      associated the LCP with the clinical care it provided, they also regarded the
      collaboration between the nurses and VHWs added additional benefits. Organised
      around the operational functions of the trial, small-scale collaborations
      provided the platform from which to build local capacity. While ethical
      guidelines emphasise the considerations that must be added to experimental
      endeavour in southern countries (e.g. elaborating processes of informed consent, 
      developing strategies of community engagement or providing therapeutic access to 
      participants after the trial concludes), these findings suggest that shifting
      attention from supplementing ethical protocols to the everyday work of research
      -embedding ethics through scientific activity - may provide a sounder basis to
      reinforce the relationship between scientific rigour and social value.
CI  - Copyright 2010 Elsevier Ltd. All rights reserved.
FAU - Kelly, Ann H
AU  - Kelly AH
AD  - London School of Hygiene and Tropical Medicine, London, UK. Electronic address:
      ann.kelly@lshtm.ac.uk.
FAU - Ameh, David
AU  - Ameh D
AD  - Medical Research Council Laboratories, Fajara, The Gambia.
FAU - Majambere, Silas
AU  - Majambere S
AD  - Ifakara Health Institute, Dar es Salaam, Tanzania; Liverpool School of Tropical
      Medicine, Liverpool, UK.
FAU - Lindsay, Steve
AU  - Lindsay S
AD  - London School of Hygiene and Tropical Medicine, London, UK; School of Biological 
      and Biomedical Sciences, Durham University, Durham, UK.
FAU - Pinder, Margaret
AU  - Pinder M
AD  - London School of Hygiene and Tropical Medicine, London, UK; Medical Research
      Council Laboratories, Fajara, The Gambia.
LA  - eng
GR  - U01 AI058250/AI/NIAID NIH HHS/United States
GR  - WT_/Wellcome Trust/United Kingdom
GR  - AI058250/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20100309
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Attitude of Health Personnel
MH  - Attitude to Health
MH  - Child
MH  - Community Health Services/*organization & administration
MH  - Community Health Workers
MH  - *Cooperative Behavior
MH  - *Ethics, Research
MH  - Female
MH  - Focus Groups
MH  - Gambia
MH  - Humans
MH  - Interprofessional Relations
MH  - Interviews as Topic
MH  - Malaria/*prevention & control
MH  - Mothers/psychology
MH  - Nurses/psychology
MH  - Professional-Patient Relations
MH  - *Sociology, Medical
PMC - PMC2877793
EDAT- 2010/04/07 06:00
MHDA- 2010/07/16 06:00
CRDT- 2010/04/06 06:00
PHST- 2009/06/30 00:00 [received]
PHST- 2010/02/06 00:00 [revised]
PHST- 2010/02/11 00:00 [accepted]
PHST- 2010/04/06 06:00 [entrez]
PHST- 2010/04/07 06:00 [pubmed]
PHST- 2010/07/16 06:00 [medline]
AID - S0277-9536(10)00171-1 [pii]
AID - 10.1016/j.socscimed.2010.02.012 [doi]
PST - ppublish
SO  - Soc Sci Med. 2010 Jun;70(12):1912-1919. doi: 10.1016/j.socscimed.2010.02.012.
      Epub 2010 Mar 9.


PMID- 20361898
OWN - NLM
STAT- MEDLINE
DCOM- 20100712
LR  - 20220321
IS  - 1555-2101 (Electronic)
IS  - 0160-6689 (Linking)
VI  - 71
IP  - 6
DP  - 2010 Jun
TI  - Clinical and ethical considerations in pharmacogenetic testing: views of
      physicians in 3 "early adopting" departments of psychiatry.
PG  - 745-53
LID - 10.4088/JCP.08m04695whi [doi]
AB  - OBJECTIVE: Pharmacogenetic testing for polymorphisms affecting drug response and 
      metabolism is now clinically available, and its use in psychiatry is expected to 
      become more widespread. Currently, few clinical and ethical standards exist for
      the use of these new tests. As a step toward building consensus about testing, we
      assessed the attitudes and practices of psychiatrists at 3 academic departments
      of psychiatry where pharmacogenetic testing is clinically available. We
      hypothesized that testing would be used primarily in treatment-resistant illness 
      and that clinicians would believe such tests carried little risk. METHOD:
      Residents and faculty at 3 departments of psychiatry considered to be "early
      adopters" of pharmacogenetic testing were invited during the academic year
      2006-2007 to complete an Internet-based survey, including questions regarding
      clinical practices and opinions about testing utility, risks, and necessary
      safeguards. RESULTS: The 75 respondents had ordered pharmacogenetic testing a
      mean of 20.86 times in the previous 12 months. Testing was judged most useful in 
      cases of treatment-resistant depression and medication intolerance. There was a
      lack of consensus about the risks of testing, particularly the risk of secondary 
      information about disease susceptibility. Respondents endorsed the use of several
      safeguards, including confidentiality, pretest and posttest counseling, and
      informed consent, but consensus about other safeguards was lacking. Women and
      those who had not ordered testing in the prior year were more concerned about
      risks and need for safeguards than were men and those who had recently ordered
      testing. CONCLUSIONS: Physicians at early adopting departments of psychiatry
      endorsed the clinical utility of pharmacogenetic testing and the use of some
      patient safeguards, but showed a lack of consensus about other safeguards and
      risks.
CI  - 2010 Physicians Postgraduate Press, Inc.
FAU - Hoop, Jinger G
AU  - Hoop JG
AD  - Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin,
      8701 Watertown Plank Road, Milwaukee, WI 53226, USA. jhoop@mcw.edu
FAU - Lapid, Maria I
AU  - Lapid MI
FAU - Paulson, Rene M
AU  - Paulson RM
FAU - Roberts, Laura Weiss
AU  - Roberts LW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100309
PL  - United States
TA  - J Clin Psychiatry
JT  - The Journal of clinical psychiatry
JID - 7801243
SB  - IM
CIN - J Clin Psychiatry. 2011 Feb;72(2):262-3. PMID: 21382312
MH  - Academic Medical Centers
MH  - *Attitude of Health Personnel
MH  - Consensus
MH  - Depressive Disorder/drug therapy/genetics
MH  - Drug-Related Side Effects and Adverse Reactions
MH  - *Ethics, Medical
MH  - Female
MH  - Genetic Counseling
MH  - Genetic Privacy/ethics/standards
MH  - Genetic Testing/*ethics/*standards
MH  - Humans
MH  - Informed Consent
MH  - Internet
MH  - Male
MH  - Pharmacogenetics/ethics/*statistics & numerical data
MH  - Physicians
MH  - Practice Patterns, Physicians'
MH  - Psychiatry/*ethics/*standards
MH  - Surveys and Questionnaires
EDAT- 2010/04/07 06:00
MHDA- 2010/07/14 06:00
CRDT- 2010/04/06 06:00
PHST- 2008/09/04 00:00 [received]
PHST- 2009/01/30 00:00 [accepted]
PHST- 2010/04/06 06:00 [entrez]
PHST- 2010/04/07 06:00 [pubmed]
PHST- 2010/07/14 06:00 [medline]
AID - 10.4088/JCP.08m04695whi [doi]
PST - ppublish
SO  - J Clin Psychiatry. 2010 Jun;71(6):745-53. doi: 10.4088/JCP.08m04695whi. Epub 2010
      Mar 9.


PMID- 20361576
OWN - NLM
STAT- MEDLINE
DCOM- 20100420
LR  - 20100405
IS  - 0020-6539 (Print)
IS  - 0020-6539 (Linking)
VI  - 60
IP  - 1
DP  - 2010 Feb
TI  - Role and models for compensation of tobacco use prevention and cessation by oral 
      health professionals.
PG  - 73-9
AB  - Appropriate compensation of tobacco use prevention and cessation (TUPAC) would
      give oral health professionals better incentives to provide TUPAC, which is
      considered part of their professional and ethical responsibility and improves
      quality of care. Barriers for compensation are that tobacco addiction is not
      recognised as a chronic disease but rather as a behavioural disorder or merely as
      a risk factor for other diseases. TUPAC-related compensation should be available 
      to oral health professionals, be in appropriate relation to other dental
      therapeutic interventions and should not be funded from existing oral health care
      budgets alone. We recommend modifying existing treatment and billing codes or
      creating new codes for TUPAC. Furthermore, we suggest a four-staged model for
      TUPAC compensation. Stages 1 and 2 are basic care, stage 3 is intermediate care
      and stage 4 is advanced care. Proceeding from stage 1 to other stages may happen 
      immediately or over many years. Stage 1: Identification and documentation of
      tobacco use is part of each patient's medical history and included into oral
      examination with no extra compensation. Stage 2: Brief intervention consists of a
      motivational interview and providing information about existing support. This
      stage should be coded/reimbursed as a short preventive intervention similar to
      other advice for oral care. Stage 3: Intermediate care consists of a motivational
      interview, assessment of tobacco dependency, informing about possible support and
      pharmacotherapy, if appropriate. This stage should be coded as preventive
      intervention similar to an oral hygiene instruction. Stage 4: Advanced care.
      Treatment codes should be created for advanced interventions by oral health
      professionals with adequate qualification. Interventions should follow
      established guidelines and use the most cost-effective approaches.
FAU - Crail, Jon
AU  - Crail J
AD  - FDI World Dental Federation, Switzerland.
FAU - Lahtinen, Aira
AU  - Lahtinen A
FAU - Beck-Mannagetta, Johann
AU  - Beck-Mannagetta J
FAU - Benzian, Habib
AU  - Benzian H
FAU - Enmarks, Birgitta
AU  - Enmarks B
FAU - Jenner, Tony
AU  - Jenner T
FAU - Knevel, Ron
AU  - Knevel R
FAU - Lulic, Martina
AU  - Lulic M
FAU - Wickholm, Seppo
AU  - Wickholm S
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int Dent J
JT  - International dental journal
JID - 0374714
SB  - IM
MH  - Current Procedural Terminology
MH  - Dental Staff/economics
MH  - *Fees, Dental
MH  - Humans
MH  - Insurance, Dental
MH  - Models, Economic
MH  - Tobacco Use Cessation/*economics
EDAT- 2010/04/07 06:00
MHDA- 2010/04/21 06:00
CRDT- 2010/04/06 06:00
PHST- 2010/04/06 06:00 [entrez]
PHST- 2010/04/07 06:00 [pubmed]
PHST- 2010/04/21 06:00 [medline]
PST - ppublish
SO  - Int Dent J. 2010 Feb;60(1):73-9.


PMID- 20361284
OWN - NLM
STAT- MEDLINE
DCOM- 20100915
LR  - 20211020
IS  - 1543-0154 (Electronic)
IS  - 0885-8195 (Linking)
VI  - 25
IP  - 2
DP  - 2010 Jun
TI  - The psychosocial oncology learning assessment: a province-wide survey of cancer
      care providers' learning needs.
PG  - 206-10
LID - 10.1007/s13187-010-0112-z [doi]
AB  - A psychosocial oncology learning needs assessment was developed and offered
      online to cancer care providers in a variety of settings across all health
      regions in British Columbia. The purpose was to better understand the
      psychosocial learning needs of cancer care providers and to use this knowledge to
      shape continuing education priorities. Respondents' preferred learning formats,
      access to technology and barriers to accessing psychosocial learning
      opportunities were also assessed. Cancer care providers including radiation
      therapists, social workers, dieticians, pharmacists, physicians and nurses in
      both community and agency settings were surveyed. Two hundred and sixty-seven
      people completed the survey. Key learning needs identified included cultural
      aspects of care, symptom management, treating the anxious patient, self-care for 
      the professional, care of elderly patients, basic cancer-related medical issues
      surrounding care and ethics. Community respondents indicated more needs than
      agency respondents. On-site training was the most preferred learning format, and 
      time constraints were the biggest barrier to accessing learning opportunities.
      Participants had access to technology. Next steps include conducting key
      informant and focus group interviews to determine if interest in a learning need 
      is the same as a relevant knowledge and practice gap. This research suggests that
      cancer care providers are interested in learning more about the psychosocial
      issues related to cancer care.
FAU - Rennie, Heather
AU  - Rennie H
AD  - Abbotsford Cancer Centre, 32900 Marshall Road, Abbotsford, BC V2S 0C2, Canada.
      hrennie@bccancer.bc.ca
FAU - Mackenzie, Gina
AU  - Mackenzie G
LA  - eng
PT  - Journal Article
DEP - 20100402
PL  - England
TA  - J Cancer Educ
JT  - Journal of cancer education : the official journal of the American Association
      for Cancer Education
JID - 8610343
SB  - IM
MH  - British Columbia
MH  - Data Collection
MH  - Humans
MH  - Internet
MH  - Medical Oncology/*education
MH  - *Needs Assessment
MH  - Neoplasms/*therapy
MH  - *Professional-Patient Relations
MH  - Psychology
EDAT- 2010/04/03 06:00
MHDA- 2010/09/16 06:00
CRDT- 2010/04/03 06:00
PHST- 2010/03/05 00:00 [received]
PHST- 2010/03/05 00:00 [accepted]
PHST- 2010/04/03 06:00 [entrez]
PHST- 2010/04/03 06:00 [pubmed]
PHST- 2010/09/16 06:00 [medline]
AID - 10.1007/s13187-010-0112-z [doi]
PST - ppublish
SO  - J Cancer Educ. 2010 Jun;25(2):206-10. doi: 10.1007/s13187-010-0112-z. Epub 2010
      Apr 2.


PMID- 20361217
OWN - NLM
STAT- MEDLINE
DCOM- 20110222
LR  - 20101026
IS  - 1438-2199 (Electronic)
IS  - 0939-4451 (Linking)
VI  - 39
IP  - 5
DP  - 2010 Nov
TI  - Amino acid metabolism in the portal-drained viscera of young pigs: effects of
      dietary supplementation with chitosan and pea hull.
PG  - 1581-7
LID - 10.1007/s00726-010-0577-4 [doi]
AB  - Recent studies indicate extensive catabolism of amino acids (AA) by the
      portal-drained viscera (PDV) of pigs and humans. Because of ethical concerns over
      invasive surgical procedures on infants or adults, in vivo investigations are
      often performed with the pig which is both an agriculturally important livestock 
      species and a widely used animal model for nutritional and physiological studies 
      in humans. Here, we described a new technique for implanting chronic catheters
      into the portal vein, ileal mesenteric vein, and carotid artery to study AA
      metabolism in the PDV of young pigs. This method allowed for the reduction of
      surgery time by 1 h and measurements of the entry of dietary AA into the portal
      circulation. Using such an approach, we found that dietary supplementation with
      100 mg/kg chitosan (a prebiotic and a polysaccharide not digested by animal
      cells) reduced oxygen consumption, as well as the net absorption of dietary AA
      into the portal vein, thereby enhancing their bioavailability for extraintestinal
      tissues. In contrast, opposite results were obtained with dietary supplementation
      of 12% pea-hull (containing 95% of fermentable nonstarch polysaccharide). Thus,
      this improved technique is useful to quantify in vivo absorption and metabolism
      of dietary AA in young pigs.
FAU - Yin, Yulong
AU  - Yin Y
AD  - Hunan Engineering and Research Center of Animal and Poultry Science, Key
      Laboratory for Agro-ecological Processes in Subtropical Region, Institute of
      Subtropical Agriculture, Chinese Academy of Sciences, Hunan, 410125, China.
      yinyulong@isa.ac.cn
FAU - Huang, Ruilin
AU  - Huang R
FAU - Li, Tiejun
AU  - Li T
FAU - Ruan, Zheng
AU  - Ruan Z
FAU - Xie, Mingyong
AU  - Xie M
FAU - Deng, Zeyuan
AU  - Deng Z
FAU - Hou, Yongqing
AU  - Hou Y
FAU - Wu, Guoyao
AU  - Wu G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100402
PL  - Austria
TA  - Amino Acids
JT  - Amino acids
JID - 9200312
RN  - 0 (Amino Acids)
RN  - 0 (Blood Glucose)
RN  - 9012-76-4 (Chitosan)
SB  - IM
MH  - Amino Acids/blood/*metabolism
MH  - Animals
MH  - Blood Glucose/analysis
MH  - Chitosan/*administration & dosage
MH  - *Dietary Supplements
MH  - Male
MH  - Oxygen Consumption
MH  - Peas/*chemistry
MH  - Swine/*metabolism
EDAT- 2010/04/03 06:00
MHDA- 2011/02/23 06:00
CRDT- 2010/04/03 06:00
PHST- 2008/08/06 00:00 [received]
PHST- 2010/03/18 00:00 [accepted]
PHST- 2010/04/03 06:00 [entrez]
PHST- 2010/04/03 06:00 [pubmed]
PHST- 2011/02/23 06:00 [medline]
AID - 10.1007/s00726-010-0577-4 [doi]
PST - ppublish
SO  - Amino Acids. 2010 Nov;39(5):1581-7. doi: 10.1007/s00726-010-0577-4. Epub 2010 Apr
      2.


PMID- 20360412
OWN - NLM
STAT- MEDLINE
DCOM- 20100716
LR  - 20161020
IS  - 1526-3347 (Electronic)
IS  - 0191-9601 (Linking)
VI  - 31
IP  - 4
DP  - 2010 Apr
TI  - Ethics for the pediatrician: pediatric research ethics: evolving principles and
      practices.
PG  - 163-5
LID - 10.1542/pir.31-4-163 [doi]
FAU - Boss, Renee D
AU  - Boss RD
AD  - Division of Neonatology, Department of Pediatrics, Johns Hopkins School of
      Medicine, Baltimore, MD, USA.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - Pediatr Rev
JT  - Pediatrics in review
JID - 8103046
SB  - IM
MH  - Child
MH  - Ethics Committees, Research
MH  - *Ethics, Research/history
MH  - History, 20th Century
MH  - Humans
MH  - Informed Consent
MH  - *Research Subjects
MH  - Risk Assessment
EDAT- 2010/04/03 06:00
MHDA- 2010/07/17 06:00
CRDT- 2010/04/03 06:00
PHST- 2010/04/03 06:00 [entrez]
PHST- 2010/04/03 06:00 [pubmed]
PHST- 2010/07/17 06:00 [medline]
AID - 31/4/163 [pii]
AID - 10.1542/pir.31-4-163 [doi]
PST - ppublish
SO  - Pediatr Rev. 2010 Apr;31(4):163-5. doi: 10.1542/pir.31-4-163.


PMID- 20359829
OWN - NLM
STAT- MEDLINE
DCOM- 20110728
LR  - 20211020
IS  - 1873-6327 (Electronic)
IS  - 0306-4603 (Linking)
VI  - 35
IP  - 7
DP  - 2010 Jul
TI  - Methods of "fake ID" obtainment and use in underage college students.
PG  - 738-40
LID - 10.1016/j.addbeh.2010.03.014 [doi]
AB  - Fake IDs are highly prevalent among underage college students, and are strongly
      associated with heavy drinking. However it is not currently known how exactly
      fake IDs are most commonly obtained and used, and how often individuals are
      caught. Such information could aid law enforcement and school personnel in their 
      enforcement responsibilities, and might further elucidate the extent and means by
      which students "make ethical compromises" to gain illegal access to alcohol. A
      cross-sectional online survey of 1098 underage students at a large Midwestern
      university indicated that comparable to previous findings, 21.0% reported
      possessing a fake ID (which was strongly associated with past-month frequent
      heavy drinking; OR=4.84, 95% CI=3.41-6.86). Of those with fake IDs, 93.5%
      reported having used them, and 29.1% reported having been caught. Greek (i.e.,
      fraternity/sorority) members were more likely than others to obtain them through 
      a Greek organization (OR=8.02, 95% CI=1.81-35.54). Also, men were more likely
      than women to buy (OR=2.74, 95% CI=1.57-4.77), yet less likely to be given them
      (OR=0.53, 95% CI=0.31-0.90). Future studies might examine whether and how fake ID
      capture reduces (or exacerbates) drinking over time.
CI  - 2010 Elsevier Ltd. All rights reserved.
FAU - Martinez, Julia A
AU  - Martinez JA
AD  - University of Missouri and the Midwest Alcoholism Research Center, Department of 
      Psychological Sciences, 200 South 7th Street, Columbia, MO 65211, USA.
      jamf22@mail.mizzou.edu
FAU - Sher, Kenneth J
AU  - Sher KJ
LA  - eng
GR  - F31 AA018590-01/AA/NIAAA NIH HHS/United States
GR  - P50 AA011998/AA/NIAAA NIH HHS/United States
GR  - R37 AA007231/AA/NIAAA NIH HHS/United States
GR  - R37 AA07231/AA/NIAAA NIH HHS/United States
GR  - T32 AA013526/AA/NIAAA NIH HHS/United States
GR  - F31 AA018590/AA/NIAAA NIH HHS/United States
GR  - F31AA018590/AA/NIAAA NIH HHS/United States
GR  - T32AA013526/AA/NIAAA NIH HHS/United States
GR  - P50 AA11998/AA/NIAAA NIH HHS/United States
GR  - K05 AA017242-01/AA/NIAAA NIH HHS/United States
GR  - K05 AA017242/AA/NIAAA NIH HHS/United States
GR  - T32 AA013526-01/AA/NIAAA NIH HHS/United States
GR  - K05AA017242/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100312
PL  - England
TA  - Addict Behav
JT  - Addictive behaviors
JID - 7603486
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Alcohol Drinking/*legislation & jurisprudence
MH  - Alcoholic Intoxication/*psychology
MH  - Cross-Sectional Studies
MH  - *Deception
MH  - Female
MH  - Humans
MH  - Male
MH  - *Records
MH  - Students/legislation & jurisprudence/*psychology
MH  - United States
MH  - Universities
PMC - PMC2856740
MID - NIHMS187684
EDAT- 2010/04/03 06:00
MHDA- 2011/07/29 06:00
CRDT- 2010/04/03 06:00
PHST- 2009/11/19 00:00 [received]
PHST- 2010/02/16 00:00 [revised]
PHST- 2010/03/05 00:00 [accepted]
PHST- 2010/04/03 06:00 [entrez]
PHST- 2010/04/03 06:00 [pubmed]
PHST- 2011/07/29 06:00 [medline]
AID - S0306-4603(10)00093-6 [pii]
AID - 10.1016/j.addbeh.2010.03.014 [doi]
PST - ppublish
SO  - Addict Behav. 2010 Jul;35(7):738-40. doi: 10.1016/j.addbeh.2010.03.014. Epub 2010
      Mar 12.


PMID- 20359805
OWN - NLM
STAT- MEDLINE
DCOM- 20100727
LR  - 20180304
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 71
IP  - 2
DP  - 2010 Jul
TI  - Context, evidence and attitude: the case for photography in medical examinations 
      of asylum seekers in the Netherlands.
PG  - 228-235
LID - S0277-9536(10)00179-6 [pii]
LID - 10.1016/j.socscimed.2010.01.049 [doi]
AB  - Can photographs of scars serve as evidence of torture? Amnesty International's
      Medical Examination Group in the Netherlands (AI-MEG) has, for more than a
      decade, been photographing torture scars to supplement the testimonies of asylum 
      seekers who have been denied refuge. AI-MEG only intervenes at this point, when
      asylum seekers face extradition. Proving allegations of torture is of vital
      importance, as asylum seekers face rising anti-immigrant sentiment in European
      countries. All victims examined by AI-MEG present a combination of mental,
      physical and emotional scars. We summarize five cases where AI-MEG used
      photography in their medical examinations, and consider the ethical role
      physicians play in helping asylum seekers obtain refuge. Though photographs
      cannot capture all forms of trauma, as visual documents, they are a compelling
      form of concrete evidence of torture. In this way, photographs complement verbal 
      testimonies and help doctors and immigration authorities to see and understand
      physical scars left by various forms of torture. AI-MEG explains in medical terms
      the connections between the visible late sequelae of torture and victims'
      testimonies. They then assess whether or not the physical scars are consistent
      with the forms of torture recounted by victims, using the terminology of the
      Istanbul Protocol (1999), the United Nations-adopted manual of guidelines that
      explains how to document torture. This paper outlines the medical examination
      process and argues for the use of photography as medical evidence on behalf of
      asylum seekers.
CI  - Copyright 2010 Elsevier Ltd. All rights reserved.
FAU - Park, Rebekah
AU  - Park R
AD  - University of California, Los Angeles, Department of Anthropology, 375 Portola
      Plaza, 341 Haines Hall Box 951553, Los Angeles, CA 90095-1553, United States.
      Electronic address: rebekahpark@gmail.com.
FAU - Oomen, Janus
AU  - Oomen J
AD  - University of Amsterdam, Oudezijds Achterburgwal 185, 1012 DK Amsterdam, The
      Netherlands.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20100310
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Adult
MH  - *Cicatrix
MH  - Emigration and Immigration/*legislation & jurisprudence
MH  - Humans
MH  - International Agencies
MH  - Male
MH  - Medical History Taking/*methods
MH  - Medical Records
MH  - Moral Obligations
MH  - Netherlands
MH  - *Photography/ethics
MH  - Physical Examination
MH  - Physician's Role
MH  - *Refugees/legislation & jurisprudence
MH  - *Torture
EDAT- 2010/04/03 06:00
MHDA- 2010/07/28 06:00
CRDT- 2010/04/03 06:00
PHST- 2009/06/16 00:00 [received]
PHST- 2010/01/16 00:00 [revised]
PHST- 2010/01/21 00:00 [accepted]
PHST- 2010/04/03 06:00 [entrez]
PHST- 2010/04/03 06:00 [pubmed]
PHST- 2010/07/28 06:00 [medline]
AID - S0277-9536(10)00179-6 [pii]
AID - 10.1016/j.socscimed.2010.01.049 [doi]
PST - ppublish
SO  - Soc Sci Med. 2010 Jul;71(2):228-235. doi: 10.1016/j.socscimed.2010.01.049. Epub
      2010 Mar 10.


PMID- 20359262
OWN - NLM
STAT- MEDLINE
DCOM- 20100629
LR  - 20220310
IS  - 1179-1969 (Electronic)
IS  - 1170-229X (Linking)
VI  - 27
IP  - 4
DP  - 2010 Apr 1
TI  - Assessment and management of pressure ulcers in the elderly: current strategies.
PG  - 311-25
LID - 10.2165/11318340-000000000-00000 [doi]
AB  - Pressure ulcers (pressure sores) continue to be a common health problem,
      particularly among the physically limited or bedridden elderly. The problem
      exists within the entire health framework, including hospitals, clinics,
      long-term care facilities and private homes. For many elderly patients, pressure 
      ulcers may become chronic for no apparent reason and remain so for prolonged
      periods, even for the remainder of the patient's lifetime. A large number of
      grade 3 and 4 pressure ulcers become chronic wounds, and the afflicted patient
      may even die from an ulcer complication (sepsis or osteomyelitis). The presence
      of a pressure ulcer constitutes a geriatric syndrome consisting of multifactorial
      pathological conditions. The accumulated effects of impairment due to immobility,
      nutritional deficiency and chronic diseases involving multiple systems predispose
      the aging skin of the elderly person to increasing vulnerability. The assessment 
      and management of a pressure ulcer requires a comprehensive and multidisciplinary
      approach in order to understand the patient with the ulcer. Factors to consider
      include the patient's underlying pathologies (such as obstructive lung disease or
      peripheral vascular disease), severity of his or her primary illness (such as an 
      infection or hip fracture), co-morbidities (such as dementia or diabetes
      mellitus), functional state (activities of daily living), nutritional status
      (swallowing difficulties), and degree of social and emotional support; focusing
      on just the wound itself is not enough. An understanding of the physiological and
      pathological processes of aging skin throws light on the aetiology and
      pathogenesis of the development of pressure ulcers in the elderly. Each health
      discipline (nursing staff, aides, physician, dietitian, occupational and physical
      therapists, and social worker) has its own role to play in the assessment and
      management of the patient with a pressure ulcer. The goals of treating a pressure
      ulcer include avoiding any preventable contributing circumstances, such as
      immobilization after a hip fracture or acute infection. Once a pressure ulcer has
      developed, however, the goal is to heal it by optimizing regional blood flow (by 
      use of a stent or vascular bypass surgery), managing underlying illnesses (such
      as diabetes, hypothyroidism or congestive heart failure) and providing adequate
      caloric and protein intake (whether through use of dietary supplements by mouth
      or by use of tube feeding). If the ulcer has become chronic, the ultimate goal
      changes from healing the wound to controlling symptoms (such as foul odour, pain,
      discomfort and infection) and preventing complications, thereby contributing to
      the patient's overall well-being; providing support for the patient's family is
      also important. Recent advances in wound dressings allow for greater control of
      symptoms and prevention of complications, and have also enabled the affected
      patient to be integrated more readily into the family setting and in the
      community at large. Ethical and end-of-life issues must also be addressed soon
      after the wound has become chronic. This article discusses the pathogenesis of
      pressure ulcer development in the elderly in relation to concomitant diseases,
      risk factor assessment and the management of such ulcers.
FAU - Jaul, Efraim
AU  - Jaul E
AD  - Skilled Geriatric Nursing Department, Herzog Hospital, Jerusalem, Israel.
      jaul@zahav.net.il
LA  - eng
PT  - Journal Article
PT  - Review
PL  - New Zealand
TA  - Drugs Aging
JT  - Drugs & aging
JID - 9102074
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Humans
MH  - Pressure Ulcer/*prevention & control/psychology/*therapy
MH  - Risk Factors
RF  - 100
EDAT- 2010/04/03 06:00
MHDA- 2010/06/30 06:00
CRDT- 2010/04/03 06:00
PHST- 2010/04/03 06:00 [entrez]
PHST- 2010/04/03 06:00 [pubmed]
PHST- 2010/06/30 06:00 [medline]
AID - 4 [pii]
AID - 10.2165/11318340-000000000-00000 [doi]
PST - ppublish
SO  - Drugs Aging. 2010 Apr 1;27(4):311-25. doi: 10.2165/11318340-000000000-00000.


PMID- 20359160
OWN - NLM
STAT- MEDLINE
DCOM- 20100511
LR  - 20100402
IS  - 0024-3477 (Print)
IS  - 0024-3477 (Linking)
VI  - 132
IP  - 1-2
DP  - 2010 Jan-Feb
TI  - [Croatian Medical Association in the period of transition 1989-1997].
PG  - 43-61
AB  - By reviewing the minutes of the 56 sessions of the Presidency and thereafter of
      the Management council of the Croatian Medical Association, the minutes of annual
      conventions and other relevant publications, the events in the Croatian Medical
      Association in the first period of social and market transition, from the first
      democratic elections in the country up to the beginning of the year 1997 are
      presented. The construction of the Association before transition, its changes in 
      the statutes during the first three years are demonstrated: the Association
      restores its old and previous denominations, the professional sections convert to
      professional societies, the secret elections for all leading places in the
      organization are introduced. One after another are presented the appeals,
      meetings and symposia that were sent or held in the headquarter at a time of
      aggression against Croatia with an aim to ask international help in the defense
      of the homeland. The conflict between the president of the Association and the
      Ministry of health and social affairs is presented, as well as the introducing of
      the Association and its societies in international organizations, the
      establishing of new scientific/professional societies, the founding of the
      Commission for human rights and medical ethics, the Norwegian initiative for
      conciliation of conflicted parties during the war, the non-held 9th and the held 
      10th Congress of Croatian physicians in Zadar. The list of succumbed Croatian
      physicians during war is presented. The Association's activity in establishing
      the Croatian Medical Chamber and thereafter the encounter Association-Chamber is 
      presented as well. The review ends by demonstration of less pronounced activities
      and by efforts to provide money necessary for renovation ofAssociation's
      building. Separately the names of colleagues who actively participated in often
      dramatic moments of transition are mentioned.
FAU - Drazancic, Ante
AU  - Drazancic A
AD  - ante.drazancic@zg.t-com.hr
FAU - Bakran, Ivan
AU  - Bakran I
LA  - hrv
PT  - English Abstract
PT  - Historical Article
PT  - Journal Article
TT  - Hrvatski lijecnicki Zbor u razdoblju tranzicije 1989-1997.
PL  - Croatia
TA  - Lijec Vjesn
JT  - Lijecnicki vjesnik
JID - 0074253
SB  - IM
MH  - Croatia
MH  - History, 20th Century
MH  - Humans
MH  - Societies, Medical/*history
EDAT- 2010/04/03 06:00
MHDA- 2010/05/12 06:00
CRDT- 2010/04/03 06:00
PHST- 2010/04/03 06:00 [entrez]
PHST- 2010/04/03 06:00 [pubmed]
PHST- 2010/05/12 06:00 [medline]
PST - ppublish
SO  - Lijec Vjesn. 2010 Jan-Feb;132(1-2):43-61.


PMID- 20359048
OWN - NLM
STAT- MEDLINE
DCOM- 20100504
LR  - 20100402
IS  - 0026-2102 (Print)
IS  - 0026-2102 (Linking)
VI  - 92
IP  - 2
DP  - 2010 Feb
TI  - The ethics of a doctor's due diligence.
PG  - 16
FAU - Johnston, Jeffery W
AU  - Johnston JW
LA  - eng
PT  - Editorial
PL  - United States
TA  - J Mich Dent Assoc
JT  - The Journal of the Michigan Dental Association
JID - 7505621
MH  - Dental Care/ethics
MH  - Dentists/*ethics
MH  - *Ethics, Dental
MH  - Evidence-Based Dentistry
MH  - Humans
EDAT- 2010/04/03 06:00
MHDA- 2010/05/05 06:00
CRDT- 2010/04/03 06:00
PHST- 2010/04/03 06:00 [entrez]
PHST- 2010/04/03 06:00 [pubmed]
PHST- 2010/05/05 06:00 [medline]
PST - ppublish
SO  - J Mich Dent Assoc. 2010 Feb;92(2):16.


PMID- 20358876
OWN - NLM
STAT- MEDLINE
DCOM- 20100504
LR  - 20100402
IS  - 0735-0732 (Print)
IS  - 0735-0732 (Linking)
VI  - 64
IP  - 4
DP  - 2010 Apr
TI  - Capitalizing hidden values from hospital assets.
PG  - 56-60
AB  - Benefits from selling noncore assets include generating capital and freeing up
      management resources. Monetization transaction structures include sale,
      partnership, and strategic affiliation. A hospital that engages in such a
      transaction needs to ensure that the purchaser or joint venture partner will
      maintain the hospital's high standards of care and ethical principles.
FAU - Beith, Carsten
AU  - Beith C
AD  - Cain Brothers & Company, LLC, Chicago, USA. cbeith@cainbrothers.com
FAU - Vaughan, James
AU  - Vaughan J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Healthc Financ Manage
JT  - Healthcare financial management : journal of the Healthcare Financial Management 
      Association
JID - 8215859
MH  - Ancillary Services, Hospital/*economics
MH  - Financial Management, Hospital/*methods
MH  - Product Line Management/*economics
MH  - United States
EDAT- 2010/04/03 06:00
MHDA- 2010/05/05 06:00
CRDT- 2010/04/03 06:00
PHST- 2010/04/03 06:00 [entrez]
PHST- 2010/04/03 06:00 [pubmed]
PHST- 2010/05/05 06:00 [medline]
PST - ppublish
SO  - Healthc Financ Manage. 2010 Apr;64(4):56-60.


PMID- 20358414
OWN - NLM
STAT- MEDLINE
DCOM- 20110412
LR  - 20211020
IS  - 1937-6995 (Electronic)
IS  - 1556-9039 (Linking)
VI  - 6
IP  - 4
DP  - 2010 Dec
TI  - A controlled clinical trial of a novel antivenom in patients envenomed by
      Bungarus multicinctus.
PG  - 393-7
LID - 10.1007/s13181-010-0051-4 [doi]
AB  - In northern Vietnam, a majority of severely envenomed patients are bitten by
      Bungarus multicinctus. Hitherto, these victims have received supportive care
      only. The aims of this study were to assess the possible efficacy and side
      effects of a new antivenom. This trial (ClinicalTrials.gov Identifier:
      NCT00811239) was performed during 2004-2006 at an ICU in Hanoi. For ethical
      reasons, the study was not randomized. All patients who fulfilled the inclusion
      criteria during 2004-2005 were prospectively enrolled, carefully recorded, and
      treated with optimal supportive therapy (control group). The patients who entered
      the study 2006 were treated with antivenom in addition to supportive care
      (antivenom group). The inclusion criteria were: envenomation by B. multicinctus, 
      presence of systemic envenomation, and (during 2006) provision of written
      informed consent. Predefined endpoints were number of patients requiring
      mechanical ventilation, duration of mechanical ventilation, length of ICU stay,
      duration of muscle paralysis, and number of patients with ventilator-associated
      pneumonia. Eighty-one patients were included, 54 during 2004-2005 and 27 during
      2006. Baseline characteristics were similar in the groups. The antivenom-group
      patients had a shorter duration of muscle paralysis of the limbs (p < 0.001), of 
      the diaphragm (p < 0.001), and of ptosis (p < 0.001). The duration of mechanical 
      ventilation and length of ICU stay were shorter in the antivenom group (p <
      0.001). The rate of ventilator-associated pneumonia was lower in the antivenom
      group (p < 0.02). However, the relative number of patients requiring mechanical
      ventilation was not reduced in the antivenom group. The rate of adverse reactions
      to the antivenom was 7.4%. A favorable efficacy and acceptable safety of this
      antivenom were demonstrated.
FAU - Ha, Tran Hung
AU  - Ha TH
AD  - Vietnam Poison Control Center, Hanoi Medical University, Hanoi, Vietnam.
FAU - Hojer, Jonas
AU  - Hojer J
FAU - Trinh, Xuan Kiem
AU  - Trinh XK
FAU - Nguyen, Thi Du
AU  - Nguyen TD
LA  - eng
SI  - ClinicalTrials.gov/NCT00811239
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Med Toxicol
JT  - Journal of medical toxicology : official journal of the American College of
      Medical Toxicology
JID - 101284598
RN  - 0 (Antivenins)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Antivenins/*therapeutic use
MH  - Blepharoptosis/*drug therapy/etiology/physiopathology
MH  - *Bungarus
MH  - Female
MH  - Humans
MH  - Intensive Care Units
MH  - Length of Stay
MH  - Male
MH  - Muscle, Skeletal/drug effects/physiopathology
MH  - Pneumonia, Ventilator-Associated
MH  - Prospective Studies
MH  - Respiration, Artificial/adverse effects
MH  - Respiratory Paralysis/*drug therapy/etiology/physiopathology
MH  - Snake Bites/complications/physiopathology/*therapy
MH  - Treatment Outcome
MH  - Vietnam
PMC - PMC3550464
EDAT- 2010/04/02 06:00
MHDA- 2011/04/13 06:00
CRDT- 2010/04/02 06:00
PHST- 2010/04/02 06:00 [entrez]
PHST- 2010/04/02 06:00 [pubmed]
PHST- 2011/04/13 06:00 [medline]
AID - 10.1007/s13181-010-0051-4 [doi]
PST - ppublish
SO  - J Med Toxicol. 2010 Dec;6(4):393-7. doi: 10.1007/s13181-010-0051-4.


PMID- 20357940
OWN - NLM
STAT- MEDLINE
DCOM- 20100407
LR  - 20160818
IS  - 0008-5286 (Print)
IS  - 0008-5286 (Linking)
VI  - 51
IP  - 1
DP  - 2010 Jan
TI  - An ethicist's commentary on euthanasia in difficult circumstances.
PG  - 28, 30
FAU - Rollin, Bernard E
AU  - Rollin BE
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Vet J
JT  - The Canadian veterinary journal = La revue veterinaire canadienne
JID - 0004653
SB  - IM
MH  - Animal Welfare/*ethics/standards
MH  - Animals
MH  - *Ethics, Professional
MH  - Euthanasia, Animal/*ethics
MH  - Humans
MH  - Veterinarians/*ethics
EDAT- 2010/04/02 06:00
MHDA- 2010/04/08 06:00
CRDT- 2010/04/02 06:00
PHST- 2010/04/02 06:00 [entrez]
PHST- 2010/04/02 06:00 [pubmed]
PHST- 2010/04/08 06:00 [medline]
PST - ppublish
SO  - Can Vet J. 2010 Jan;51(1):28, 30.


PMID- 20357733
OWN - NLM
STAT- MEDLINE
DCOM- 20100805
LR  - 20110614
IS  - 1643-3750 (Electronic)
IS  - 1234-1010 (Linking)
VI  - 16
IP  - 4
DP  - 2010 Apr
TI  - Advances in the research of fetal DNA in maternal plasma for noninvasive prenatal
      diagnostics.
PG  - RA85-91
AB  - Molecular analysis of fetal DNA present in the maternal circulation allows
      noninvasive, early, and precise determination of fetal genetic status in prenatal
      diagnostics. The most common clinical applications, i.e. prenatal gender
      determination and fetal RhD genotyping, are possible already in the first
      trimester using specialized protocols for DNA isolation from plasma and
      subsequent real-time PCR detection. Recent advances in molecular techniques
      enable other applications of fetal DNA purified from maternal plasma samples.
      Chromosomal abnormalities (e.g. trisomy 21) can be diagnosed by digital PCR,
      which offers higher accuracy in quantifying DNA sequences than standard real-time
      PCR. Digital PCR, but also MALDI-TOF, are suitable for detecting point mutations,
      widening the spectrum of applications to monogenic diseases. The ongoing lowering
      of costs for massively parallel sequencing might lead to replacement of most of
      the other currently used approaches. Adopting specialized protocols for the
      purification of fragmented circulating fetal DNA and improving the bioinformatic 
      analysis of raw data can bring us closer to sequencing the fetal genome as the
      ultimate goal of prenatal DNA diagnostics, with wide-ranging medical
      applications. The discussion and solution of ethical issues beyond early fetal
      gender or paternity determination is hanging just behind the rapid technical
      progress of noninvasive prenatal DNA diagnostics.
FAU - Vlkova, Barbora
AU  - Vlkova B
AD  - Geneton Inc., Bratislava, Slovakia.
FAU - Szemes, Tomas
AU  - Szemes T
FAU - Minarik, Gabriel
AU  - Minarik G
FAU - Turna, Jan
AU  - Turna J
FAU - Celec, Peter
AU  - Celec P
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and
      clinical research
JID - 9609063
RN  - 0 (Nucleic Acids)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Alleles
MH  - Chromosome Aberrations
MH  - DNA/*metabolism
MH  - Female
MH  - Fetus/metabolism
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Methylation
MH  - Nucleic Acids/blood
MH  - Polymerase Chain Reaction/methods
MH  - Pregnancy
MH  - Prenatal Diagnosis/*methods
MH  - Sequence Analysis, DNA/*methods
MH  - Sex Determination Analysis
MH  - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
RF  - 75
EDAT- 2010/04/02 06:00
MHDA- 2010/08/06 06:00
CRDT- 2010/04/02 06:00
PHST- 2010/04/02 06:00 [entrez]
PHST- 2010/04/02 06:00 [pubmed]
PHST- 2010/08/06 06:00 [medline]
AID - 878492 [pii]
PST - ppublish
SO  - Med Sci Monit. 2010 Apr;16(4):RA85-91.


PMID- 20357521
OWN - NLM
STAT- MEDLINE
DCOM- 20100813
LR  - 20100512
IS  - 1423-0372 (Electronic)
IS  - 1011-6125 (Linking)
VI  - 88
IP  - 3
DP  - 2010
TI  - Defining the intercommissural plane and stereotactic coordinates for the Basal
      Ganglia in the Gottingen minipig brain.
PG  - 138-46
LID - 10.1159/000303526 [doi]
AB  - The intercommissural line joining the anterior and posterior commissures defines 
      stereotactic coordinate systems used in functional neurosurgical procedures. Such
      coordinate systems are generally accepted in humans and nonhuman primate
      experimental settings and provide high stereotactic precision and
      reproducibility. The ethical concern surrounding the use of nonhuman primates has
      motivated and helped popularize the use of the Gottingen minipig as an
      alternative experimental model for experimental functional neurosurgery. We
      investigated the position and variability of the intercommissural line in the
      minipig brain using in vivo MRI. From these data, standard coordinates for the
      minipig basal ganglia were estimated. We found the variability of the
      intercommissural line to be small in the Gottingen minipig and the variability of
      the basal ganglia structures to the mid-commissural point to be minor.
FAU - Rosendal, Frederikke
AU  - Rosendal F
AD  - Department of Neurosurgery, Aarhus University, Aarhus, Denmark. frosendal @
      hotmail.com
FAU - Chakravarty, M Mallar
AU  - Chakravarty MM
FAU - Sunde, Niels
AU  - Sunde N
FAU - Rodell, Anders
AU  - Rodell A
FAU - Jonsdottir, Kristjana Y
AU  - Jonsdottir KY
FAU - Pedersen, Michael
AU  - Pedersen M
FAU - Bjarkam, Carsten
AU  - Bjarkam C
FAU - Sorensen, Jens Christian
AU  - Sorensen JC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100401
PL  - Switzerland
TA  - Stereotact Funct Neurosurg
JT  - Stereotactic and functional neurosurgery
JID - 8902881
SB  - IM
MH  - Animals
MH  - Basal Ganglia/*anatomy & histology/surgery
MH  - Brain Mapping
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Models, Anatomic
MH  - Models, Neurological
MH  - Reference Values
MH  - *Stereotaxic Techniques
MH  - Swine/*anatomy & histology/surgery
MH  - Swine, Miniature
EDAT- 2010/04/02 06:00
MHDA- 2010/08/14 06:00
CRDT- 2010/04/02 06:00
PHST- 2009/05/29 00:00 [received]
PHST- 2009/11/30 00:00 [accepted]
PHST- 2010/04/02 06:00 [entrez]
PHST- 2010/04/02 06:00 [pubmed]
PHST- 2010/08/14 06:00 [medline]
AID - 000303526 [pii]
AID - 10.1159/000303526 [doi]
PST - ppublish
SO  - Stereotact Funct Neurosurg. 2010;88(3):138-46. doi: 10.1159/000303526. Epub 2010 
      Apr 1.


PMID- 20356779
OWN - NLM
STAT- MEDLINE
DCOM- 20100826
LR  - 20211020
IS  - 1873-2054 (Electronic)
IS  - 1353-8292 (Linking)
VI  - 16
IP  - 4
DP  - 2010 Jul
TI  - Airports, localities and disease: representations of global travel during the
      H1N1 pandemic.
PG  - 727-35
LID - 10.1016/j.healthplace.2010.03.004 [doi]
AB  - During summer 2009, the UK experienced one of the highest incidences of H1N1
      infection outside of the Americas and Australia. Building on existing research
      into biosecurity and the spread of infectious disease via the global airline
      network, this paper explores the biopolitics of public health in the UK through
      an in-depth empirical analysis of the representation of H1N1 in UK national and
      regional newspapers. We uncover new discourses relating to the significance of
      the airport as a site for control and the ethics of the treatment of the
      traveller as a potential transmitter of disease. We conclude by highlighting how 
      the global spread of infectious diseases is grounded in particular localities
      associated with distinctive notions of biosecurity and the traveller.
CI  - 2010 Elsevier Ltd. All rights reserved.
FAU - Warren, Adam
AU  - Warren A
AD  - Department of Geography, Loughborough University, Loughborough, Leicestershire
      LE113TU, UK. a.p.warren@lboro.ac.uk
FAU - Bell, Morag
AU  - Bell M
FAU - Budd, Lucy
AU  - Budd L
LA  - eng
PT  - Journal Article
DEP - 20100315
PL  - England
TA  - Health Place
JT  - Health & place
JID - 9510067
MH  - Attitude to Health
MH  - Aviation/ethics/*statistics & numerical data
MH  - Communicable Diseases, Emerging/epidemiology/prevention & control/transmission
MH  - Disease Outbreaks/ethics/prevention & control
MH  - Family Practice/statistics & numerical data
MH  - *Global Health
MH  - Humans
MH  - Incidence
MH  - Infection Control/methods
MH  - *Influenza A Virus, H1N1 Subtype
MH  - Influenza, Human/epidemiology/*prevention & control/transmission
MH  - Journalism, Medical
MH  - Mass Media
MH  - Newspapers as Topic/*statistics & numerical data
MH  - Politics
MH  - Public Health Practice/ethics
MH  - Safety Management/ethics/methods
MH  - Travel/ethics/*statistics & numerical data
MH  - United Kingdom/epidemiology
PMC - PMC7185730
EDAT- 2010/04/02 06:00
MHDA- 2010/08/27 06:00
CRDT- 2010/04/02 06:00
PHST- 2009/09/28 00:00 [received]
PHST- 2010/01/21 00:00 [revised]
PHST- 2010/03/09 00:00 [accepted]
PHST- 2010/04/02 06:00 [entrez]
PHST- 2010/04/02 06:00 [pubmed]
PHST- 2010/08/27 06:00 [medline]
AID - S1353-8292(10)00032-8 [pii]
AID - 10.1016/j.healthplace.2010.03.004 [doi]
PST - ppublish
SO  - Health Place. 2010 Jul;16(4):727-35. doi: 10.1016/j.healthplace.2010.03.004. Epub
      2010 Mar 15.


PMID- 20356439
OWN - NLM
STAT- MEDLINE
DCOM- 20100804
LR  - 20170208
IS  - 1008-1275 (Print)
IS  - 1008-1275 (Linking)
VI  - 13
IP  - 2
DP  - 2010 Apr 1
TI  - Establishment of the model of motorcyclist ejection injury.
PG  - 67-71
AB  - OBJECTIVE: To establish the device and model of motorcyclist ejection injury.
      METHODS: Based on our laboratory devices, a motorcyclist ejection injury
      simulation system was developed. A total of 18 pigs were approved by the local
      animal experimentation and ethics committee to serve as the motorcyclist
      substitutes. In this ejection motion, the animal rode freely at the motor driver 
      seat and was straightly accelerated by means of our custom motorcyclist ejection 
      injury simulation system. When it was speeded up to the preset velocity (v equal 
      to 30, 40 or 50 km/h) at the preset position, the animal was ejected forward.
      Pathological and dynamic analyses were conducted, accompanied with the high-speed
      photograph, acceleration/velocity signal test, gross observation and light
      microscope examination as well as the abbreviated injury score-injury severity
      score (AIS-ISS) scale. RESULTS: The high-speed photograph indicated that during
      the ejection procedure the motorcycle was first arrested and decelerated
      suddenly, and then the motorcycle driver was ejected forward, accompanied with
      the rotation motion in the air. Finally, the head, shoulder and thorax of the
      ejected animal impacted directly on the hard ground. Varying degrees of injury
      focusing on the liver, heart, lung and spleen were found. There existed a
      significant positive correlation between ISS and the ejection velocity of the
      motorcycle drivers (ISS equal to 16.7+/-2.9 for 30 km/h, 25.0+/-0.0 for 40 km/h
      and 37.3+/-1.0 for 50 km/h). The detailed injury characteristics were as follows:
      for the mildly injured animals, there were interlobar gaps or leaf gaps and lobar
      surface blood coagulation blocks in the liver, and mild lung hemorrhage; for the 
      severely injured animals, there were liver comminuted laceration, moderate lung
      hemorrhage and heart injury. Animals suffering from the most severe injuries died
      half an hour later. CONCLUSION: The new injury model stated in this paper has a
      high stability and good repeatability, and is likely to be helpful to deeply
      investigate the injury mechanisms and protection countermeasures of motorcyclist 
      ejection injury.
FAU - Chen, Hai-bin
AU  - Chen HB
AD  - State Key Laboratory of Trauma, Burns, and Combined Injury, Institute of Surgery 
      Research, Daping Hospital, Third Military Medical University, Chongqing, China.
      chenhb1996@vip.163.com
FAU - Hang, Jian-jin
AU  - Hang JJ
FAU - Zhang, Bo
AU  - Zhang B
FAU - Liu, Da-wei
AU  - Liu DW
FAU - Yang, Guang-yu
AU  - Yang GY
FAU - Wang, Zheng-guo
AU  - Wang ZG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Chin J Traumatol
JT  - Chinese journal of traumatology = Zhonghua chuang shang za zhi
JID - 100886162
SB  - IM
MH  - *Accidents, Traffic
MH  - Animals
MH  - *Disease Models, Animal
MH  - *Motorcycles
MH  - Swine
MH  - Wounds and Injuries/diagnosis/*etiology/pathology
EDAT- 2010/04/02 06:00
MHDA- 2010/08/05 06:00
CRDT- 2010/04/02 06:00
PHST- 2010/04/02 06:00 [entrez]
PHST- 2010/04/02 06:00 [pubmed]
PHST- 2010/08/05 06:00 [medline]
AID - S1008-1275(10)60013-2 [pii]
PST - ppublish
SO  - Chin J Traumatol. 2010 Apr 1;13(2):67-71.


PMID- 20355358
OWN - NLM
STAT- MEDLINE
DCOM- 20100610
LR  - 20181201
IS  - 0027-9684 (Print)
IS  - 0027-9684 (Linking)
VI  - 102
IP  - 3
DP  - 2010 Mar
TI  - Ronda S. Henry-Tillman, MD, FACS.
PG  - 257
AB  - Dr Henry-Tillman was recently appointed as a member of the Advisory Committee on 
      Research on Women's Health at the National Institutes of Health (NIH). This
      committee assists the Office of Research on Women's Health (ORWH) and the NIH in 
      addressing scientific, legal, and ethical issues affecting the health of the
      nation's women through biomedical and behavioral research and related career
      opportunities. The ORWH was established in 1990 by the NIH and statutorily
      mandated by Congress in 1993 as a mechanism for eliciting advice and
      recommendations on priority issues affecting women's health research. Advisory
      committee members are expected to provide guidance in such areas as refinement of
      the NIH's women's health research agenda, exploration of questions regarding
      gender difference in clinical drug trials, development of methodologies that
      enhance research on health needs of women, and monitoring the inclusion of women 
      in clinical trials funded by the NIH. The director of the Office of Research on
      Women's Health is Dr Vivian W. Pinn, former president of the National Medical
      Association.
FAU - Henry-Tillman, Ronda S
AU  - Henry-Tillman RS
AD  - University of Arkansas for Medical Sciences, Cancer Control, Cancer Institute,
      Ladies' Oncology Clinic, Little Rock, Arkansas 72205 USA. henryrondas@uams.edu
LA  - eng
PT  - Biography
PT  - Historical Article
PT  - Journal Article
PT  - Portrait
PL  - United States
TA  - J Natl Med Assoc
JT  - Journal of the National Medical Association
JID - 7503090
SB  - IM
MH  - Arkansas
MH  - Female
MH  - History, 21st Century
MH  - Humans
MH  - Medical Oncology/*history
MH  - Women's Health/*history
PS  - Henry-Tillman RS
FPS - Henry-Tillman, Rhonda S
EDAT- 2010/04/02 06:00
MHDA- 2010/06/11 06:00
CRDT- 2010/04/02 06:00
PHST- 2010/04/02 06:00 [entrez]
PHST- 2010/04/02 06:00 [pubmed]
PHST- 2010/06/11 06:00 [medline]
AID - S0027-9684(15)30534-4 [pii]
PST - ppublish
SO  - J Natl Med Assoc. 2010 Mar;102(3):257.


PMID- 20354636
OWN - NLM
STAT- MEDLINE
DCOM- 20100622
LR  - 20151119
IS  - 1474-9092 (Electronic)
IS  - 1474-905X (Linking)
VI  - 9
IP  - 4
DP  - 2010 Apr
TI  - Molecular modifications of dermal and epidermal biomarkers following UVA
      exposures on reconstructed full-thickness human skin.
PG  - 439-47
LID - 10.1039/b9pp00164f [doi]
AB  - Ultraviolet A (UVA) radiation adversely affects skin health and appearance via
      multiple molecular pathways. Biologically relevant UVA damage are classified as
      short-term effects (e.g. formation of reactive oxygen species [ROS],
      inflammation, photo-oxidation, DNA damage, immunosuppression, photoallergy and
      cell-mediated contact hypersensitivity) or long-term effects (elastosis,
      photoageing and photocarcinogenesis). Single and chronic experimental exposure to
      UVA are limited in humans by ethical concerns, and furthermore it is impossible
      to quantify long-term endpoints such as photoageing over the life-span of a human
      volunteer. The aim of the present study was to investigate the biological
      relevance of the Phenion FT skin model for use in photobiological studies.
      Biological responses to acute and repeated UVA exposures were investigated by
      monitoring the kinetics of gene expression during the post-irradiation period. By
      using a dynamic approach, we were able to define early and stable markers of
      UVA-induced effects that could be predictive of UVA damage in vivo. The
      transcriptomic approach applied to 3D human tissues appears to be an encouraging 
      method for gaining a deeper understanding of the UVA effects on skin and for
      studying the dermal response with non-invasive techniques.
FAU - Meloni, Marisa
AU  - Meloni M
AD  - VitroScreen, In Vitro Research laboratories, 103, Via Mose Bianchi, 20149, Milan,
      Italy. marisa.meloni@vitroscreen.com
FAU - Farina, Anne
AU  - Farina A
FAU - de Servi, Barbara
AU  - de Servi B
LA  - eng
PT  - Journal Article
PL  - England
TA  - Photochem Photobiol Sci
JT  - Photochemical & photobiological sciences : Official journal of the European
      Photochemistry Association and the European Society for Photobiology
JID - 101124451
RN  - 0 (Biomarkers)
RN  - 0 (Sunscreening Agents)
SB  - IM
MH  - Biomarkers/metabolism
MH  - Dermis/anatomy & histology/drug effects/*metabolism/*radiation effects
MH  - Environmental Exposure/*adverse effects
MH  - Epidermis/anatomy & histology/drug effects/*metabolism/*radiation effects
MH  - Fluorescent Antibody Technique
MH  - Gene Expression Profiling
MH  - Humans
MH  - *Models, Anatomic
MH  - Oxidative Stress/drug effects/genetics/radiation effects
MH  - Photobiology/methods
MH  - Radiation Dosage
MH  - Skin Aging/drug effects/genetics/radiation effects
MH  - Sunscreening Agents/pharmacology
MH  - Time Factors
MH  - Transcription, Genetic/drug effects/radiation effects
MH  - Ultraviolet Rays/*adverse effects
EDAT- 2010/04/01 06:00
MHDA- 2010/06/23 06:00
CRDT- 2010/04/01 06:00
PHST- 2010/04/01 06:00 [entrez]
PHST- 2010/04/01 06:00 [pubmed]
PHST- 2010/06/23 06:00 [medline]
AID - 10.1039/b9pp00164f [doi]
PST - ppublish
SO  - Photochem Photobiol Sci. 2010 Apr;9(4):439-47. doi: 10.1039/b9pp00164f.


PMID- 20354410
OWN - NLM
STAT- MEDLINE
DCOM- 20100617
LR  - 20100331
IS  - 1538-9049 (Electronic)
IS  - 1098-7886 (Linking)
VI  - 26
IP  - 2
DP  - 2010 Mar-Apr
TI  - American Nurses Association's code of ethics: an application.
PG  - 85-7
LID - 10.1097/NND.0b013e3181d4d3c0 [doi]
FAU - Mikos-Schild, Sophia
AU  - Mikos-Schild S
AD  - Resurrection Healthcare, St. Mary and Elizabeth Medical Center, Chicago, IL, USA.
      sschild@reshealthcare.org
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Nurses Staff Dev
JT  - Journal for nurses in staff development : JNSD : official journal of the National
      Nursing Staff Development Organization
JID - 9809908
MH  - *American Nurses' Association/organization & administration
MH  - *Codes of Ethics
MH  - Faculty, Nursing/*organization & administration
MH  - Humans
MH  - *Nurse's Role
MH  - Patient Advocacy/ethics
MH  - Practice Guidelines as Topic
MH  - Professional Autonomy
MH  - United States
EDAT- 2010/04/01 06:00
MHDA- 2010/06/18 06:00
CRDT- 2010/04/01 06:00
PHST- 2010/04/01 06:00 [entrez]
PHST- 2010/04/01 06:00 [pubmed]
PHST- 2010/06/18 06:00 [medline]
AID - 10.1097/NND.0b013e3181d4d3c0 [doi]
AID - 00124645-201003000-00010 [pii]
PST - ppublish
SO  - J Nurses Staff Dev. 2010 Mar-Apr;26(2):85-7. doi: 10.1097/NND.0b013e3181d4d3c0.


PMID- 20354099
OWN - NLM
STAT- MEDLINE
DCOM- 20100618
LR  - 20190709
IS  - 1943-4723 (Electronic)
IS  - 0002-8177 (Linking)
VI  - 141
IP  - 4
DP  - 2010 Apr
TI  - How do I ethically handle a request for confidentiality by an elderly patient?
PG  - 463-4
FAU - Foy, Patrick J
AU  - Foy PJ
AD  - American Dental Association Council on Ethics, Bylaws and Judicial Affairs, 211
      E. Chicago Ave., Chicago, IL 60611, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Am Dent Assoc
JT  - Journal of the American Dental Association (1939)
JID - 7503060
SB  - IM
MH  - Aged
MH  - American Dental Association
MH  - Codes of Ethics
MH  - Confidentiality/*ethics
MH  - Dental Care for Aged/*ethics
MH  - *Ethics, Dental
MH  - Health Insurance Portability and Accountability Act
MH  - Humans
MH  - United States
EDAT- 2010/04/01 06:00
MHDA- 2010/06/19 06:00
CRDT- 2010/04/01 06:00
PHST- 2010/04/01 06:00 [entrez]
PHST- 2010/04/01 06:00 [pubmed]
PHST- 2010/06/19 06:00 [medline]
AID - 141/4/463 [pii]
AID - 10.14219/jada.archive.2010.0202 [doi]
PST - ppublish
SO  - J Am Dent Assoc. 2010 Apr;141(4):463-4. doi: 10.14219/jada.archive.2010.0202.


PMID- 20353857
OWN - NLM
STAT- MEDLINE
DCOM- 20110406
LR  - 20110424
IS  - 1579-2129 (Electronic)
IS  - 0300-2896 (Linking)
VI  - 46 Suppl 2
DP  - 2010 Mar
TI  - [Issues in vaccination against influenza A in Spain].
PG  - 32-8
LID - 10.1016/S0300-2896(10)70018-1 [doi]
AB  - Given the threat of an avian influenza A (H5N1) pandemic, vaccines that could be 
      used in a new influenza pandemic began to be developed in 2004. The possible
      pandemic scenarios included highly serious situations with high incidence and
      mortality. Due to the need for the greatest possible number of vaccines to be
      available in a short period of time, studies with "model" vaccines were started, 
      which allowed the immunogenicity and safety of the vaccines to be determined
      before identifying which virus would cause the pandemic. The use of adjuvants
      also formed part of these strategies. Subsequently, studies with the pandemic A
      (H1N1) strain were performed and additional studies continue to be performed. The
      vaccination strategies adopted have not been aimed at containing the infection
      but rather at ameliorating its effects. The choice of candidate groups for
      vaccination was not made hastily but after evaluating a large body of information
      on the epidemiology of the disease and the characteristics of the available
      vaccines. The population to be vaccinated is basically the same as that
      recommended to undergo seasonal influenza vaccination. In the ethical context of 
      primum non nocere special emphasis has been placed on the vaccination of health
      personnel. All the available information supports the safety of the adjuvants and
      preservatives used in some of the authorized vaccines, as stated by the World
      Health Organization and many other prestigious organizations. So far 65 million
      doses have been administered throughout the world and the various adverse events 
      detected by surveillance systems have been similar to those observed with other
      influenza vaccines and those that could be expected among millions of persons.
      Lessons must be drawn from the course of the present pandemic and the strategies 
      used to deal with this situation as there will be other pandemics.
CI  - Copyright (c) 2010 Sociedad Espanola de Neumologia y Cirugia Toracica. Published 
      by Elsevier Espana. All rights reserved.
FAU - Bayas Rodriguez, Jose M
AU  - Bayas Rodriguez JM
AD  - Centro de Vacunacion de Adultos, Servicio de Medicina Preventiva y Epidemiologia,
      UASP, Hospital Clinic, Barcelona, Espana. jmbayas@clinic.ub.es
FAU - Garcia-Basteiro, Alberto L
AU  - Garcia-Basteiro AL
FAU - Mena Pinilla, Guillermo
AU  - Mena Pinilla G
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Problematica de la vacunacion contra la gripe A en Espana.
PL  - Spain
TA  - Arch Bronconeumol
JT  - Archivos de bronconeumologia
JID - 0354720
RN  - 0 (Influenza Vaccines)
SB  - IM
MH  - Humans
MH  - Influenza A Virus, H1N1 Subtype/immunology
MH  - Influenza A virus/*immunology
MH  - *Influenza Vaccines/adverse effects
MH  - Influenza, Human/epidemiology/*prevention & control
MH  - Pandemics
MH  - Spain
EDAT- 2010/04/01 06:00
MHDA- 2011/04/07 06:00
CRDT- 2010/04/01 06:00
PHST- 2010/04/01 06:00 [entrez]
PHST- 2010/04/01 06:00 [pubmed]
PHST- 2011/04/07 06:00 [medline]
AID - S0300-2896(10)70018-1 [pii]
AID - 10.1016/S0300-2896(10)70018-1 [doi]
PST - ppublish
SO  - Arch Bronconeumol. 2010 Mar;46 Suppl 2:32-8. doi: 10.1016/S0300-2896(10)70018-1.


PMID- 20353717
OWN - NLM
STAT- MEDLINE
DCOM- 20100720
LR  - 20100331
IS  - 1646-0758 (Electronic)
IS  - 0870-399X (Linking)
VI  - 23
IP  - 1
DP  - 2010 Jan-Feb
TI  - [Breach of confidentiality in medicine].
PG  - 141-8
AB  - This paper deals with the historical development of the legal protection of
      medical confidentiality in Portugal. Situations that have lead to its
      relativization, and the present Portuguese legal framework (Criminal Code and the
      Code of Professional Ethics of the Ordem dos Medicos) are analysed. Finally, the 
      paper focuses on the implementation of the legal framework, taking into account
      the specific situation of HIV/AIDS.
FAU - Rueff, Maria do Ceu
AU  - Rueff Mdo C
AD  - Centro de Direito Biomedico da Universidade de Coimbra, Universidade Lusiada,
      Lisboa.
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Violacao de segredo em medicina.
DEP - 20100210
PL  - Portugal
TA  - Acta Med Port
JT  - Acta medica portuguesa
JID - 7906803
SB  - IM
MH  - Confidentiality/*ethics
MH  - *Ethics, Medical
EDAT- 2010/04/01 06:00
MHDA- 2010/07/21 06:00
CRDT- 2010/04/01 06:00
PHST- 2010/04/01 06:00 [entrez]
PHST- 2010/04/01 06:00 [pubmed]
PHST- 2010/07/21 06:00 [medline]
PST - ppublish
SO  - Acta Med Port. 2010 Jan-Feb;23(1):141-8. Epub 2010 Feb 10.


PMID- 20353658
OWN - NLM
STAT- MEDLINE
DCOM- 20100607
LR  - 20161125
IS  - 1355-7610 (Print)
IS  - 1355-7610 (Linking)
VI  - 17
IP  - 2
DP  - 2010 Apr
TI  - Developing a mentoring culture in dentistry. Making a difference in a changing
      world.
PG  - 93-8
LID - 10.1308/135576110791013811 [doi]
AB  - This paper follows the recent series published in Primary Dental Care on the
      subject of mentoring. It is intended to place mentoring in a broader societal,
      professional, ethical and philosophical context. The introduction of the
      mentoring approach into human affairs in general, and the workplace in
      particular, is evidence of a fundamental shift both in the way we work together
      as individuals and in how we view and value ourselves as human beings. This paper
      reflects on the changes in thinking and attitudes in society that have led to the
      emergence of mentoring and coaching as elements in the approach of positive
      psychology. It then seeks to learn from the experience of the adoption of
      mentoring and coaching in other areas of work and society. It goes on to consider
      what impact this might have on underlying beliefs and attitudes within the
      profession of dentistry, and who might become the mentors and the mentees.
      Finally, it presents mentoring as an expression of the values and the culture of 
      a caring profession seeking to promote the 'good life' both for its patients and 
      for its practitioners.
FAU - Holt, Vernon P
AU  - Holt VP
AD  - Holt, Norfolk, UK. vernon@doctorslodge.co.uk
FAU - Ladwa, Russ
AU  - Ladwa R
LA  - eng
PT  - Journal Article
PL  - England
TA  - Prim Dent Care
JT  - Primary dental care : journal of the Faculty of General Dental Practitioners (UK)
JID - 9617339
MH  - Clinical Competence
MH  - Dental Care/standards
MH  - Education, Dental, Continuing/*methods
MH  - Humans
MH  - *Mentors
MH  - Organizational Culture
MH  - Social Values
MH  - Staff Development
MH  - United Kingdom
EDAT- 2010/04/01 06:00
MHDA- 2010/06/09 06:00
CRDT- 2010/04/01 06:00
PHST- 2010/04/01 06:00 [entrez]
PHST- 2010/04/01 06:00 [pubmed]
PHST- 2010/06/09 06:00 [medline]
AID - 10.1308/135576110791013811 [doi]
PST - ppublish
SO  - Prim Dent Care. 2010 Apr;17(2):93-8. doi: 10.1308/135576110791013811.


PMID- 20353588
OWN - NLM
STAT- MEDLINE
DCOM- 20100916
LR  - 20211020
IS  - 1471-2466 (Electronic)
IS  - 1471-2466 (Linking)
VI  - 10
DP  - 2010 Mar 30
TI  - No effect of epoprostenol on right ventricular diameter in patients with acute
      pulmonary embolism: a randomized controlled trial.
PG  - 18
LID - 10.1186/1471-2466-10-18 [doi]
AB  - BACKGROUND: Right ventricular dilatation in the setting of acute pulmonary
      embolism is associated with an adverse prognosis. Treatment with a pulmonary
      vasodilator has never been studied systematically. We evaluated the effect of
      epoprostenol on right ventricular diameter and function in patients with acute
      pulmonary embolism and right ventricular dilatation. METHODS: In a randomized,
      single-blind study, 14 patients with acute pulmonary embolism received
      epoprostenol or placebo infusion for 24 hours on top of conventional treatment.
      Effects on right ventricular end-diastolic diameter, systolic pulmonary artery
      pressure, right ventricle fractional area change and tricuspid annular plane
      systolic excursion were assessed by serial echocardiography. Furthermore Troponin
      T and NT-proBNP were measured serially. RESULTS: Compared to placebo,
      epoprostenol was associated with a relative change from baseline in right
      ventricular end-diastolic diameter of +2% after 2.5 hours and -8% after 24 hours.
      Epoprostenol did not have a significant effect on systolic pulmonary artery
      pressure, right ventricular fractional area change and tricuspid annular plane
      systolic excursion, nor on biochemical parameters. CONCLUSION: In patients with
      acute pulmonary embolism and right ventricular overload, treatment with
      epoprostenol did not improve right ventricular dilatation or any other measured
      variables of right ventricular overload. TRIAL REGISTRATION: REGISTRATION: URL:
      NCT01014156Medical ethical committee: Medisch-ethische toetsingscommissie (METc) 
      from the VUmc (free university medical centre).
FAU - Kooter, Albertus J
AU  - Kooter AJ
AD  - Department of Internal Medicine, VU University Medical Center, Amsterdam, the
      Netherlands. jkooter@vumc.nl
FAU - Ijzerman, Richard G
AU  - Ijzerman RG
FAU - Kamp, Otto
AU  - Kamp O
FAU - Boonstra, Anco B
AU  - Boonstra AB
FAU - Smulders, Yvo M
AU  - Smulders YM
LA  - eng
SI  - ClinicalTrials.gov/NCT01014156
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20100330
PL  - England
TA  - BMC Pulm Med
JT  - BMC pulmonary medicine
JID - 100968563
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Peptide Fragments)
RN  - 0 (Troponin T)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - DCR9Z582X0 (Epoprostenol)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antihypertensive Agents/adverse effects/*pharmacology
MH  - Blood Pressure/drug effects/physiology
MH  - Echocardiography, Doppler
MH  - Epoprostenol/adverse effects/*pharmacology
MH  - Female
MH  - Heart Ventricles/diagnostic imaging/*drug effects/*pathology
MH  - Humans
MH  - Hypertrophy, Right Ventricular/diagnostic imaging/*pathology/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/blood
MH  - Peptide Fragments/blood
MH  - Pulmonary Embolism/diagnostic imaging/*pathology/physiopathology
MH  - Single-Blind Method
MH  - Troponin T/blood
MH  - Ventricular Dysfunction, Right/physiopathology
PMC - PMC2859373
EDAT- 2010/04/01 06:00
MHDA- 2010/09/18 06:00
CRDT- 2010/04/01 06:00
PHST- 2009/10/05 00:00 [received]
PHST- 2010/03/30 00:00 [accepted]
PHST- 2010/04/01 06:00 [entrez]
PHST- 2010/04/01 06:00 [pubmed]
PHST- 2010/09/18 06:00 [medline]
AID - 1471-2466-10-18 [pii]
AID - 10.1186/1471-2466-10-18 [doi]
PST - epublish
SO  - BMC Pulm Med. 2010 Mar 30;10:18. doi: 10.1186/1471-2466-10-18.


PMID- 20353411
OWN - NLM
STAT- MEDLINE
DCOM- 20101025
LR  - 20181201
IS  - 1526-4637 (Electronic)
IS  - 1526-2375 (Linking)
VI  - 11
IP  - 6
DP  - 2010 Jun
TI  - Gabapentin does not reduce preoperative anxiety when given prior to total hip
      arthroplasty.
PG  - 966-71
LID - 10.1111/j.1526-4637.2010.00826.x [doi]
AB  - INTRODUCTION: Gabapentin is an anti-epileptic drug which is also used for the
      treatment of postoperative pain and a variety of psychiatric diseases including
      chronic anxiety disorders. We tested the hypothesis that compared with a placebo 
      control, gabapentin would reduce preoperative anxiety in patients undergoing
      total hip arthroplasty. METHODS: Following ethics approval, patients
      participating in a larger double blind, randomized, trial of multimodal analgesia
      were given either gabapentin 600 mg (N = 22) or placebo (N = 48) 2 hours before
      spinal anesthesia. Prior to administering the study medication, baseline anxiety 
      levels were measured using a visual analog scale (VAS). Two hours after the
      ingestion of gabapentin or placebo, and prior to surgery, patients again rated
      their anxiety using a VAS. RESULTS: Anxiety scores did not differ significantly
      between the groups either before (P = 0.95) or 2 hours after (P = 0.61) ingestion
      of gabapentin or placebo. Baseline anxiety and postdrug anxiety scores failed to 
      demonstrate a significant association with maximal postoperative pain at rest,
      maximal postoperative pain with movement, and cumulative morphine consumption 48 
      hours after surgery. CONCLUSIONS: Administration of gabapentin 600 mg prior to
      surgery does not reduce preoperative anxiety.
FAU - Clarke, Hance
AU  - Clarke H
AD  - Department of Anesthesia and Pain Management, Toronto General Hospital, Toronto, 
      Ontario, Canada. hance.clarke@utoronto.ca
FAU - Kay, Joseph
AU  - Kay J
FAU - Orser, Beverley A
AU  - Orser BA
FAU - Gollish, Jeffrey
AU  - Gollish J
FAU - Mitsakakis, Nicholas
AU  - Mitsakakis N
FAU - Katz, Joel
AU  - Katz J
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20100326
PL  - England
TA  - Pain Med
JT  - Pain medicine (Malden, Mass.)
JID - 100894201
RN  - 0 (Amines)
RN  - 0 (Anti-Anxiety Agents)
RN  - 0 (Cyclohexanecarboxylic Acids)
RN  - 0 (Placebos)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - 6CW7F3G59X (Gabapentin)
SB  - IM
MH  - Aged
MH  - Amines/*therapeutic use
MH  - Anti-Anxiety Agents/*therapeutic use
MH  - Anxiety/*drug therapy/etiology
MH  - Arthroplasty, Replacement, Hip/*psychology
MH  - Cyclohexanecarboxylic Acids/*therapeutic use
MH  - Double-Blind Method
MH  - Female
MH  - Gabapentin
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Placebos/therapeutic use
MH  - *Preoperative Period
MH  - Treatment Outcome
MH  - gamma-Aminobutyric Acid/*therapeutic use
EDAT- 2010/04/01 06:00
MHDA- 2010/10/26 06:00
CRDT- 2010/04/01 06:00
PHST- 2010/04/01 06:00 [entrez]
PHST- 2010/04/01 06:00 [pubmed]
PHST- 2010/10/26 06:00 [medline]
AID - PME826 [pii]
AID - 10.1111/j.1526-4637.2010.00826.x [doi]
PST - ppublish
SO  - Pain Med. 2010 Jun;11(6):966-71. doi: 10.1111/j.1526-4637.2010.00826.x. Epub 2010
      Mar 26.


PMID- 31508028
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1749-3676 (Print)
IS  - 1749-3676 (Linking)
VI  - 7
IP  - 2
DP  - 2010 Apr
TI  - Twenty-five years of expectation: where are the services for older people with
      mental illness in Africa?
PG  - 32-34
AB  - Mental health disorders account for about 14% of the global burden of disease.
      Neuropsychiatric disorders may be responsible for more than 1.2 million deaths
      annually (Prince et al, 2007). Around 80% of those affected live in low- and
      middle-income countries. Yet, despite the fact that older persons carry a
      disproportionate burden of non-communicable disease and mental disorder, they are
      not seen as priority issues for healthcare provision in these countries.
      Logically and ethically, older persons should be prioritised for targeted
      interventions, alongside the generic strengthening of primary and community
      health provision. African governments, spurred on by the specific agendas of
      non-governmental and parastatal organisations, continue with more urgent tasks;
      their healthcare provision is oriented towards the 'younger generations'
      (maternal and child healthcare, and infection). In most African countries, the
      expenditure specifically targeted for mental health is below 1% of the total
      healthcare budget, that is, effectively non-existent (Saxena et al, 2007).
FAU - Clausen, Thomas
AU  - Clausen T
AD  - Norwegian Centre for Addiction Research (SERAF), University of Oslo, Norway,
      email thomas.clausen@medisin.uio.no.
FAU - Wilson, Adrian O
AU  - Wilson AO
AD  - African Foundation for Research and Interdisciplinary Training in Ageing, Harare,
      Zimbabwe.
LA  - eng
PT  - Journal Article
DEP - 20100401
PL  - England
TA  - Int Psychiatry
JT  - International psychiatry : bulletin of the Board of International Affairs of the 
      Royal College of Psychiatrists
JID - 101189664
PMC - PMC6734960
EDAT- 2010/04/01 00:00
MHDA- 2010/04/01 00:01
CRDT- 2019/09/12 06:00
PHST- 2019/09/12 06:00 [entrez]
PHST- 2010/04/01 00:00 [pubmed]
PHST- 2010/04/01 00:01 [medline]
PST - epublish
SO  - Int Psychiatry. 2010 Apr 1;7(2):32-34. eCollection 2010 Apr.


PMID- 29213671
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220311
IS  - 1980-5764 (Print)
IS  - 1980-5764 (Linking)
VI  - 4
IP  - 2
DP  - 2010 Apr-Jun
TI  - Distinct attitudes of professionals from different medical specialties toward
      autonomy and legal instruments in the assessment of patients with Alzheimer's
      disease.
PG  - 104-108
LID - 10.1590/S1980-57642010DN40200005 [doi]
AB  - The evaluation of competence of Alzheimer's disease (AD) patients to assume
      personal or collective responsibilities and the resulting legal implications is a
      relevant issue. OBJECTIVES: The aim of this study was to evaluate the attitudes
      of different medical specialists towards the disability of patients with
      Alzheimer's disease and practitioners' competence to interfere with
      decision-making autonomy. METHODS: Professionals from different areas (Neurology,
      Psychiatry, Geriatrics, and General Practice) were interviewed by one of the
      authors, after being presented a fictitious clinical case which raised several
      topics, namely:[1] Critical judgment and capacity of the patient to take
      decisions related to daily activities;[2] The role of family physicians in
      nominating trustees and caregivers. RESULTS: Answers to the first question did
      not differ regarding degree of preservation of awareness but at least 25%
      stressed that the patient must be carefully listened to, independent of caregiver
      or legal representative opinion. There were significant knowledge gaps in
      responses to the second question. Half of the physicians interviewed did not have
      adequate information about the legal aspects of caring for patients with
      Alzheimer's disease. CONCLUSIONS: Legal aspects is a topic that must be
      incorporated into professional training in order to improve attitudes toward the 
      long-term management of patients with dementia.
FAU - Pioltini, Ana Beatriz Maringolo
AU  - Pioltini ABM
AD  - Fourth-year Medical Student, Botucatu Medical School, Sao Paulo State University 
      (UNESP), Botucatu SP, Brazil. FAPESP Fellows.
FAU - Mendes-Chiloff, Cristiane Lara
AU  - Mendes-Chiloff CL
AD  - Psychologist, Department of Neurology, Psychology, and Psychiatry, Botucatu
      Medical School, Sao Paulo State University (UNESP), Botucatu SP, Brazil.
FAU - Schelp, Arthur Oscar
AU  - Schelp AO
AD  - Neurologist, Department of Neurology, Psychology, and Psychiatry, Botucatu
      Medical School, Sao Paulo State University (UNESP), Botucatu SP, Brazil.
FAU - Marcolino, Everson da Silva
AU  - Marcolino EDS
AD  - Lawyer, Sao Paulo Federal Justice Department.
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - Dement Neuropsychol
JT  - Dementia & neuropsychologia
JID - 101506587
PMC - PMC5619167
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - attitudes
OT  - ethical and legal aspects
COIS- Disclosure: The authors report no conflicts of interest.
EDAT- 2010/04/01 00:00
MHDA- 2010/04/01 00:01
CRDT- 2017/12/08 06:00
PHST- 2017/12/08 06:00 [entrez]
PHST- 2010/04/01 00:00 [pubmed]
PHST- 2010/04/01 00:01 [medline]
AID - 10.1590/S1980-57642010DN40200005 [doi]
PST - ppublish
SO  - Dement Neuropsychol. 2010 Apr-Jun;4(2):104-108. doi:
      10.1590/S1980-57642010DN40200005.


PMID- 28839535
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 2041-4137 (Print)
IS  - 2041-4137 (Linking)
VI  - 1
IP  - 1
DP  - 2010 Apr
TI  - Ethical issues in nutrition support: a view from the coalface.
PG  - 7-12
LID - 10.1136/fg.2009.000240 [doi]
AB  - Artificial nutrition and hydration continue to stimulate debate among physicians 
      and in the wider world. This review aims to give those involved in providing
      nutrition support the necessary tools to be confident in making decisions in
      individual cases. It examines basic ethical principles and suggests a structured 
      approach to ensure all the relevant factors are considered in making decisions.
      The current legal context and in particular the provisions of the Mental Capacity
      Act 2005 relating to nutrition support are discussed. The review concludes by
      applying the ethical approach suggested to some clinical examples, demonstrating 
      the decision making process.
FAU - Simmonds, Nicola J
AU  - Simmonds NJ
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100401
PL  - England
TA  - Frontline Gastroenterol
JT  - Frontline gastroenterology
JID - 101528589
PMC - PMC5517158
COIS- Competing interests: None.
EDAT- 2010/04/01 00:00
MHDA- 2010/04/01 00:01
CRDT- 2017/08/26 06:00
PHST- 2017/08/26 06:00 [entrez]
PHST- 2010/04/01 00:00 [pubmed]
PHST- 2010/04/01 00:01 [medline]
AID - 10.1136/fg.2009.000240 [doi]
AID - flgastro-2009-000240 [pii]
PST - ppublish
SO  - Frontline Gastroenterol. 2010 Apr;1(1):7-12. doi: 10.1136/fg.2009.000240. Epub
      2010 Apr 1.


PMID- 25860416
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150414
LR  - 20150411
IS  - 1608-5906 (Print)
IS  - 1608-5906 (Linking)
VI  - 9
IP  - 1
DP  - 2010 Apr
TI  - Challenging power and meaning: outlining the popular epidemiology of HIV and AIDS
      in Rakai, Uganda, c. 1975-1990.
PG  - 81-94
LID - 10.2989/16085906.2010.484584 [doi]
AB  - This article traces the historical evolution of conditions that favoured the
      spread of HIV in Rakai district, Uganda, and the process of evolution of the
      local, popular epidemiology of HIV and AIDS. It argues that the HIV epidemic was 
      made possible by economic and social disparities, which grew more pronounced
      since the mid-1970s as a result of economic decline, physical insecurity, and the
      disbanding of public services. The local constructions of AIDS in Rakai have
      changed and shifted according to the progress of the epidemic, eventually
      challenging the initial cultural construction of the disease, based on local
      notions about causality between disease and morality. The progress of the
      epidemic undermined the local intellectual authority (e.g. traditional healers,
      health workers, and religious leaders), creating a need to produce additional
      explanations of the disease. The concept of 'Slim' in Rakai emerged as a popular 
      construct to denote the physical, psychological and social consequences of HIV
      disease. The concept reflects popular concerns over the outcomes of the epidemic 
      rather than its cause, being more concerned about the fate of individuals and
      communities than about issues of morality. Later, the moral construction of
      'Slim' that accompanied the biomedical categorisation of AIDS as a sexually
      transmitted disease made it appear as a disease of sexual indulgence and
      promiscuity. The bio-moral construction of 'Slim' was also challenged by local
      evangelical claims about the power of faith and morality to regenerate its
      'victims,' something that biomedicine had not been able to provide. As the
      disease has become part of the social ecology of Rakai and the rest of Uganda,
      interpretations of it will continue to be challenged and reconstructed.
FAU - Kuhanen, Jan
AU  - Kuhanen J
AD  - a Department of History , University of Joensuu , PO Box 111 , Joensuu , 80101 , 
      Finland.
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - Afr J AIDS Res
JT  - African journal of AIDS research : AJAR
JID - 101146510
OTO - NOTNLM
OT  - Africa
OT  - cultural beliefs
OT  - ethical issues
OT  - health beliefs
OT  - history
OT  - social exclusion
OT  - socio-cultural aspects
EDAT- 2010/04/01 00:00
MHDA- 2010/04/01 00:01
CRDT- 2015/04/11 06:00
PHST- 2015/04/11 06:00 [entrez]
PHST- 2010/04/01 00:00 [pubmed]
PHST- 2010/04/01 00:01 [medline]
AID - 10.2989/16085906.2010.484584 [doi]
PST - ppublish
SO  - Afr J AIDS Res. 2010 Apr;9(1):81-94. doi: 10.2989/16085906.2010.484584.


PMID- 24479189
OWN - NLM
STAT- MEDLINE
DCOM- 20140502
LR  - 20191112
IS  - 0748-1187 (Print)
IS  - 0748-1187 (Linking)
VI  - 34
IP  - 4
DP  - 2010 Apr
TI  - Psychological and ethical considerations concerning the debreather and assisted
      suicide: a commentary on Ogden.
PG  - 318-24
AB  - This article offers a commentary on the report by Russel Ogden (2010/this issue) 
      on the use of the "debreather" for suicide assistance by the NuTech (or New
      Technologies for Self-Deliverance) program. The emergence of NuTech is set within
      its historical and political context. Nu Tech is criticized for its anarchic and 
      extreme advocacy of self-determination to the neglect of other psychological and 
      ethical considerations (e.g., the individual's emotional state, the mutability of
      his or her quality of life, and his or her decision-making capacity). Some of the
      risks of covert, unregulated, assisted death are noted as is a potential shift in
      healthcare that might diminish interest in the undignified NuTech methods of
      dying.
FAU - Kleespies, Phillip M
AU  - Kleespies PM
AD  - Department of Psychiatry, Boston University School of Medicine, Boston,
      Massachusetts, USA. phillip.kleespies@aol.com
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Death Stud
JT  - Death studies
JID - 8506890
CON - Death Stud. 2010 Apr;34(4):291-317. PMID: 24479188
CIN - Death Stud. 2010 Apr;34(4):325-9. PMID: 24479190
MH  - *Asphyxia
MH  - *Equipment and Supplies
MH  - *Euthanasia
MH  - Female
MH  - Humans
MH  - Male
MH  - *Personal Autonomy
MH  - *Suicide, Assisted
EDAT- 2010/04/01 00:00
MHDA- 2014/05/03 06:00
CRDT- 2014/01/31 06:00
PHST- 2014/01/31 06:00 [entrez]
PHST- 2010/04/01 00:00 [pubmed]
PHST- 2014/05/03 06:00 [medline]
AID - 10.1080/07481181003613859 [doi]
PST - ppublish
SO  - Death Stud. 2010 Apr;34(4):318-24. doi: 10.1080/07481181003613859.


PMID- 23331351
OWN - NLM
STAT- MEDLINE
DCOM- 20130618
LR  - 20130121
IS  - 1753-6405 (Electronic)
IS  - 1326-0200 (Linking)
VI  - 34
IP  - 2
DP  - 2010 Apr
TI  - Law, ethics and pandemic preparedness: the importance of cross-jurisdictional and
      cross-cultural perspectives.
PG  - 106-12
LID - 10.1111/j.1753-6405.2010.00492.x [doi]
AB  - OBJECTIVE: To explore social equity, health planning, regulatory and ethical
      dilemmas in responding to a pandemic influenza (H5N1) outbreak, and the adequacy 
      of protocols and standards such as the International Health Regulations (2005).
      APPROACH: This paper analyses the role of legal and ethical considerations for
      pandemic preparedness, including an exploration of the relevance of
      cross-jurisdictional and cross-cultural perspectives in assessing the validity of
      goals for harmonisation of laws and policies both within and between nations.
      Australian and international experience is reviewed in various areas, including
      distribution of vaccines during a pandemic, the distribution of authority between
      national and local levels of government, and global and regional equity issues
      for poorer countries. CONCLUSION: This paper finds that questions such as those
      of distributional justice (resource allocation) and regulatory frameworks raise
      important issues about the cultural and ethical acceptability of planning
      measures. Serious doubt is cast on a 'one size fits all' approach to
      international planning for managing a pandemic. It is concluded that a more
      nuanced approach than that contained in international guidelines may be required 
      if an effective response is to be constructed internationally. IMPLICATIONS: The 
      paper commends the wisdom of reliance on 'soft law', international guidance that 
      leaves plenty of room for each nation to construct its response in conformity
      with its own cultural and value requirements.
CI  - (c) 2010 The Authors. Journal Compilation (c) 2010 Public Health Association of
      Australia.
FAU - Bennett, Belinda
AU  - Bennett B
AD  - Faculty of Law, University of Sydney, New South Wales, Australia.
      belinda.bennett@sydney.edu.au
FAU - Carney, Terry
AU  - Carney T
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Aust N Z J Public Health
JT  - Australian and New Zealand journal of public health
JID - 9611095
RN  - 0 (Influenza Vaccines)
SB  - IM
MH  - Animals
MH  - Birds
MH  - Cross-Cultural Comparison
MH  - Culture
MH  - Disaster Planning/legislation & jurisprudence/*organization & administration
MH  - Health Planning/ethics/legislation & jurisprudence/*organization & administration
MH  - Health Policy/*legislation & jurisprudence
MH  - Humans
MH  - Influenza A Virus, H5N1 Subtype
MH  - Influenza Vaccines
MH  - Influenza in Birds/epidemiology/prevention & control
MH  - Influenza, Human/epidemiology/prevention & control
MH  - Pandemics/ethics/legislation & jurisprudence/*prevention & control
MH  - Public Health/ethics
MH  - Resource Allocation
MH  - Social Justice
EDAT- 2010/04/01 00:00
MHDA- 2013/06/19 06:00
CRDT- 2013/01/22 06:00
PHST- 2013/01/22 06:00 [entrez]
PHST- 2010/04/01 00:00 [pubmed]
PHST- 2013/06/19 06:00 [medline]
AID - 10.1111/j.1753-6405.2010.00492.x [doi]
PST - ppublish
SO  - Aust N Z J Public Health. 2010 Apr;34(2):106-12. doi:
      10.1111/j.1753-6405.2010.00492.x.


PMID- 22810290
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20120719
IS  - 1080-2371 (Print)
IS  - 1080-2371 (Linking)
VI  - 16
IP  - 2 Dementia
DP  - 2010 Apr
TI  - Ethical perspectives in neurology.
PG  - 224-7
LID - 10.1212/01.CON.0000368222.40201.2b [doi]
FAU - Rabins, Peter V
AU  - Rabins PV
FAU - Black, Betty S
AU  - Black BS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Continuum (Minneap Minn)
JT  - Continuum (Minneapolis, Minn.)
JID - 9509333
EDAT- 2010/04/01 00:00
MHDA- 2010/04/01 00:01
CRDT- 2012/07/20 06:00
PHST- 2012/07/20 06:00 [entrez]
PHST- 2010/04/01 00:00 [pubmed]
PHST- 2010/04/01 00:01 [medline]
AID - 10.1212/01.CON.0000368222.40201.2b [doi]
AID - 00132979-201004000-00015 [pii]
PST - ppublish
SO  - Continuum (Minneap Minn). 2010 Apr;16(2 Dementia):224-7. doi:
      10.1212/01.CON.0000368222.40201.2b.


PMID- 22691854
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20131203
IS  - 1394-035X (Print)
IS  - 1394-035X (Linking)
VI  - 16
IP  - 1
DP  - 2010 Apr
TI  - Comparison of Food Choice Motives between Malay Husbands and Wives in an Urban
      Community.
PG  - 69-81
AB  - The main objective of this study was to determine the motives underlying the
      selection of foods between husbands and wives in an urban community.
      Thiscross-sectional study was carried out in Bandar Baru Bangi, Selangor,
      Malaysia among 150 married couples aged 20 and above, who voluntarily agreed to
      participate and were not on any special diet. Data were collected using the Food 
      Choice Questionnaire (FCQ) which measured the health-related and non health
      related factor that influence people's food choices. It consisted of 36 items
      designed to assess the reported importance of nine factors: health, mood,
      convenience, sensory appeal, natural content, price, weight control, familiarity,
      and ethical concern. In this study, the FCQ was adapted and a new factor,
      religion (religious guidelines), was included. Demographic characteristics
      including age, occupation, education, household income and household size were
      also collected. Data were analysed using SPSS version 16. Results showed that
      40.7% of husbands (mean age= 43.33 + 11.16 years) and 55.3% of wives (mean age=
      41.28 + 10.93 years) perceived themselves as the main food shopper while 12.0% of
      the husbands and 85.3% of the wives perceived themselves as the main meal
      planner. Husbands rated religion as the most prominent factor in food choice
      motives with a mean average rating of 4.56 + 0.59 on a 5-point rating scale,
      followed by health and convenience factor. Meanwhile, the wives rated health as
      the most essential factor with mean average rating of 4.49 + 0.58, followed by
      religion and convenience factor. Sensory appeal, ethical concerns and familiarity
      were rated as the bottom three factors of food choice motives among these two
      groups. Price of foods was not considered as an important factor in making food
      choices for the subjects in this study. In conclusion, the husbands and wives of 
      this urban community rated religion, health and convenience as the three most
      important food choice motives in food selection.
FAU - Asma, A
AU  - Asma A
AD  - Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences
      Universiti Putra Malaysia.
FAU - Nawalyah, A G
AU  - Nawalyah AG
FAU - Rokiah, M Y
AU  - Rokiah MY
FAU - Mohd Nasir, M T
AU  - Mohd Nasir MT
LA  - eng
PT  - Journal Article
DEP - 20100415
PL  - Malaysia
TA  - Malays J Nutr
JT  - Malaysian journal of nutrition
JID - 101286655
EDAT- 2010/04/01 00:00
MHDA- 2010/04/01 00:01
CRDT- 2012/06/14 06:00
PHST- 2012/06/14 06:00 [entrez]
PHST- 2010/04/01 00:00 [pubmed]
PHST- 2010/04/01 00:01 [medline]
PST - ppublish
SO  - Malays J Nutr. 2010 Apr;16(1):69-81. Epub 2010 Apr 15.


PMID- 22506090
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1939-2389 (Print)
IS  - 1939-2389 (Linking)
VI  - 3
IP  - 2
DP  - 2010 Spring
TI  - Control of Extensively Drug-Resistant Tuberculosis (XDR-TB): A Root Cause
      Analysis.
PG  - 1-20
AB  - The threat of global infectious agents has the potential to cripple national and 
      global economies, as the outbreaks of SARS, Avian Flu, H1N1, and XDR-TB have
      demonstrated. This article offers a Root Cause Analysis (RCA) of one public
      health case study - the Speaker case of XDR-TB - pinpointing the underlying
      causal relationships associated with this global health incident and proposing
      recommendations for preventing its recurrence. An RCA approach identifies
      corrective actions directed at the root causes of the problem and advances them
      as necessary to eliminate global contagion with its major international public
      health risks. To my knowledge, this is the first root cause analysis of a global 
      health problem. The reform this article proposes would be to add a standardized
      procedure akin to the informed consent process in clinical ethics, but within a
      shared health governance framework. This approach, addressing infectious agents
      at their origins or source, is potentially a more effective strategy to reduce
      uncertainty and avert global health threats.
FAU - Ruger, Jennifer Prah
AU  - Ruger JP
AD  - Associate Professor at Yale University Schools of Medicine, Public Health and Law
      (Adjunct) and Graduate School of Arts and Sciences.
LA  - eng
GR  - K01 DA016358/DA/NIDA NIH HHS/United States
GR  - K01 DA016358-05/DA/NIDA NIH HHS/United States
PT  - Journal Article
DEP - 20100401
PL  - United States
TA  - Glob Health Gov
JT  - Global health governance : the scholarly journal for the new health security
      paradigm
JID - 101318458
PMC - PMC3324909
MID - NIHMS220273
EDAT- 2010/04/01 00:00
MHDA- 2010/04/01 00:01
CRDT- 2012/04/17 06:00
PHST- 2012/04/17 06:00 [entrez]
PHST- 2010/04/01 00:00 [pubmed]
PHST- 2010/04/01 00:01 [medline]
PST - ppublish
SO  - Glob Health Gov. 2010 Spring;3(2):1-20. Epub 2010 Apr 1.


PMID- 21702295
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20220311
IS  - 1025-9589 (Print)
IS  - 1025-9589 (Linking)
VI  - 22
IP  - 2
DP  - 2010 Apr-Jun
TI  - Frequency of hepatitis B and C in patients undergoing elective surgery.
PG  - 167-70
AB  - BACKGROUND: Viral Hepatitis (HBV and HCV) is a major health problem affecting
      approximately two billion population worldwide. It is one of the single most
      important cause of chronic liver disease and hepato-cellular carcinoma in
      Pakistan and worldwide and is now spreading beyond endemic dimensions. This study
      was carried out to assess the frequency of Hepatitis B and C infection in
      patients undergoing elective surgical operations, and to evaluate the associated 
      risk factors. METHODS: This was a descriptive study, conducted at Surgical
      Department of Ghulam Muhammad Mahar Medical College Hospital, Sukkur, from April 
      2009 to March 2010. All patients who were admitted in the Surgical Department for
      elective surgical operations were included in the study. The patients were
      screened for HBsAg and Anti-HCV using immunochromatography (ICT) method. Those
      who were weak positive by ICT were further confirmed by ELISA. RESULTS: Total 913
      patients were admitted in Surgical Department during study period for elective
      operations and were screened for HBsAg and Anti-HCV. Out of these, 572 (62.65%)
      were male and 341 (37.34%) were female. Mean age of these patients was 40 years. 
      After screening, 33 (3.61%) patients were found HBsAg positive and 117 (12.8%)
      were Anti-HCV positive, while 9 (0.98%) were positive for both. Hepatitis-B was
      found in 21 (2.3%) males and 12 (1.3%) females, and Hepatitis-C was found in 68
      (7.44%) males and 49 (5.36%) female patients. Parenteral injections by quacks,
      previous surgery, blood transfusion and shaving by barbers were found to be the
      risk factors. CONCLUSION: Our message is: 'Prevention is better than cure'. It is
      essential to prevent spread of Hepatitis B and C by screening every patient
      before surgery and counselling the patients. The doctors and paramedical staff
      must follow proper ethical practice ensuring use of sterile disposables where
      indicated and protecting patients and themselves from these viral infections.
FAU - Memon, Muhammad Rafique
AU  - Memon MR
AD  - Department of Surgery, Ghulam Muhammad Mahar Medical College Hospital, Sukkur,
      Pakistan. drrafiqmemonsuk@yahoo.com
FAU - Shaikh, Altaf Ahmed
AU  - Shaikh AA
FAU - Soomro, Aftab Ahmed
AU  - Soomro AA
FAU - Arshad, Saima
AU  - Arshad S
FAU - Shah, Qarib Abbas
AU  - Shah QA
LA  - eng
PT  - Journal Article
PL  - Pakistan
TA  - J Ayub Med Coll Abbottabad
JT  - Journal of Ayub Medical College, Abbottabad : JAMC
JID - 8910750
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Child
MH  - Cohort Studies
MH  - *Elective Surgical Procedures
MH  - Female
MH  - Hepatitis B/*complications/*epidemiology
MH  - Hepatitis C/*complications/*epidemiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pakistan
MH  - Retrospective Studies
MH  - Young Adult
EDAT- 2010/04/01 00:00
MHDA- 2011/07/27 06:00
CRDT- 2011/06/28 06:00
PHST- 2011/06/28 06:00 [entrez]
PHST- 2010/04/01 00:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
PST - ppublish
SO  - J Ayub Med Coll Abbottabad. 2010 Apr-Jun;22(2):167-70.


PMID- 21702291
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20110627
IS  - 1025-9589 (Print)
IS  - 1025-9589 (Linking)
VI  - 22
IP  - 2
DP  - 2010 Apr-Jun
TI  - Pre-examination stress in second year medical students in a government college.
PG  - 152-5
AB  - BACKGROUND: Pre-examination Stress is a common condition faced by students prior 
      to exams and is quite predominant among medical students. Many studies have been 
      conducted to assess the impact of stress on students prior to examinations. This 
      study however aims to determine the behavioural and physiological changes
      occurring in the second year medical students during the pre-examination period. 
      METHODS: Questionnaires were distributed among students to review the changes
      that occurred in medical students related to their behaviour, physical activities
      and functions just before exams. Duration of study was two months from
      October-November, 2009. The questionnaire was divided into two parts. The first
      part contained demographic information about the patient, the second part
      contained opinions of students experiencing pre-examination stress. SPSS was used
      for data management and approval from the Ethical Review Board of Dow University 
      of Health Sciences was obtained before starting the research. RESULTS: The data
      for this study was collected from 226 students of 2nd year MBBS, Dow Medical
      College, Karachi on specially designed questionnaires. Among the 226 students
      22.1% were male while 77.9% were female with mean age 20 +/- 1 years. Changes
      observed in pre-examination period included anorexia, nausea, fatigue (54.87%),
      changed concentration span (80.09%), increased irritability (68.14%), mood swings
      (50.88%), disturbed menstrual cycle (15.91%), disturbed sleep cycle (80.97%),
      increased intake of caffeine/energy drinks (38.94%), disturbed metabolism
      (46.02%), aggravated skin problems such as acne (12.83%). Among the 226 students 
      42.04% did regular exercise and 76.12% prayed regularly. Both of these factors
      helped them in coping with stress. CONCLUSION: Majority included in our research 
      experienced stress prior to exams but the signs and symptoms varied greatly.
      Irritability, increased intake of caffeine/energy drinks, and disturbed sleep
      cycle seemed to dominate physiological and behavioural changes in the
      pre-examination period.
FAU - Rizvi, Areeba Husain
AU  - Rizvi AH
AD  - Dow Medical College, Karachi, Pakistan. areebarizvi@yahoo.com
FAU - Awaiz, Maha
AU  - Awaiz M
FAU - Ghanghro, Zohra
AU  - Ghanghro Z
FAU - Jafferi, Mehjabeen Ahmed
AU  - Jafferi MA
FAU - Aziz, Sina
AU  - Aziz S
LA  - eng
PT  - Journal Article
PL  - Pakistan
TA  - J Ayub Med Coll Abbottabad
JT  - Journal of Ayub Medical College, Abbottabad : JAMC
JID - 8910750
SB  - IM
MH  - *Education, Medical, Undergraduate
MH  - Educational Measurement
MH  - Female
MH  - Humans
MH  - Male
MH  - Stress, Psychological/*epidemiology
MH  - Students, Medical/*psychology
MH  - Young Adult
EDAT- 2010/04/01 00:00
MHDA- 2011/07/27 06:00
CRDT- 2011/06/28 06:00
PHST- 2011/06/28 06:00 [entrez]
PHST- 2010/04/01 00:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
PST - ppublish
SO  - J Ayub Med Coll Abbottabad. 2010 Apr-Jun;22(2):152-5.


PMID- 21691444
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220409
IS  - 1527-8565 (Print)
IS  - 1527-8565 (Linking)
VI  - 11
IP  - 2
DP  - 2010 Spring
TI  - Information and Communication Technologies in Social Work.
PG  - 67-81
AB  - Information and communication technologies (ICTs) are electronic tools used to
      convey, manipulate and store information. The exponential growth of Internet
      access and ICTs greatly influenced social, political, and economic processes in
      the United States, and worldwide. Regardless of the level of practice, ICTs will 
      continue influencing the careers of social workers and the clients they serve.
      ICTs have received some attention in the social work literature and curriculum,
      but we argue that this level of attention is not adequate given their ubiquity,
      growth and influence, specifically as it relates to upholding social work ethics.
      Significant attention is needed to help ensure social workers are responsive to
      the technological changes in the health care system, including the health care
      infrastructure and use of technology among clients. Social workers also need ICT 
      competencies in order to effectively lead different types of social change
      initiatives or collaborate with professionals of other disciplines who are using 
      ICTs as part of existing strategies. This paper also identifies potential
      pitfalls and challenges with respect to the adoption of ICTs, with
      recommendations for advancing their use in practice, education, and research.
FAU - Perron, Brian E
AU  - Perron BE
AD  - School of Social Work at the University of Michigan.
FAU - Taylor, Harry O
AU  - Taylor HO
FAU - Glass, Joseph E
AU  - Glass JE
FAU - Margerum-Leys, Jon
AU  - Margerum-Leys J
LA  - eng
GR  - R03 AA019575/AA/NIAAA NIH HHS/United States
GR  - T32 MH019960/MH/NIMH NIH HHS/United States
GR  - T32 MH019960-18/MH/NIMH NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Adv Soc Work
JT  - Advances in social work
JID - 100911381
PMC - PMC3117433
MID - NIHMS299321
EDAT- 2010/04/01 00:00
MHDA- 2010/04/01 00:01
CRDT- 2011/06/22 06:00
PHST- 2011/06/22 06:00 [entrez]
PHST- 2010/04/01 00:00 [pubmed]
PHST- 2010/04/01 00:01 [medline]
PST - ppublish
SO  - Adv Soc Work. 2010 Spring;11(2):67-81.


PMID- 20591023
OWN - NLM
STAT- MEDLINE
DCOM- 20120106
LR  - 20100701
IS  - 1440-1797 (Electronic)
IS  - 1320-5358 (Linking)
VI  - 15 Suppl 1
DP  - 2010 Apr
TI  - The CARI guidelines. Ethical considerations.
PG  - S12-4
LID - 10.1111/j.1440-1797.2010.01225.x [doi]
FAU - Kainer, Gad
AU  - Kainer G
FAU - Fetherstonhaugh, Deirdre
AU  - Fetherstonhaugh D
CN  - CARI
LA  - eng
PT  - Journal Article
PT  - Practice Guideline
PL  - Australia
TA  - Nephrology (Carlton)
JT  - Nephrology (Carlton, Vic.)
JID - 9615568
SB  - IM
MH  - Humans
MH  - Informed Consent
MH  - Kidney Failure, Chronic/*therapy
MH  - Renal Dialysis/*ethics
EDAT- 2010/04/01 00:00
MHDA- 2012/01/10 06:00
CRDT- 2010/07/02 06:00
PHST- 2010/07/02 06:00 [entrez]
PHST- 2010/04/01 00:00 [pubmed]
PHST- 2012/01/10 06:00 [medline]
AID - NEP1225 [pii]
AID - 10.1111/j.1440-1797.2010.01225.x [doi]
PST - ppublish
SO  - Nephrology (Carlton). 2010 Apr;15 Suppl 1:S12-4. doi:
      10.1111/j.1440-1797.2010.01225.x.


PMID- 20590360
OWN - NLM
STAT- MEDLINE
DCOM- 20160422
LR  - 20181201
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Linking)
VI  - 11 Suppl 1
DP  - 2010
TI  - Ethical dilemmas and the dying Muslim patient.
PG  - 107-12
AB  - All health care providers may be confronted by a Muslim patient, but many health 
      care professionals are lacking basic knowledge on the Muslim faith and medical
      ethics based on Islamic law (Shariah). One must endeavour to differentiate
      between ethnic customs and Islamic tradition. It is important for staff to have a
      general understanding of the principles of Islamic beliefs and actions to attain 
      better cultural competency and improved patient care. Terminally ill cancer
      patients are vulnerable and require sensitive care of their physical,
      psycho-social, cultural and spiritual aspects and needs. Muslims believe that the
      purpose of life is a test from God with the objective of full obedience, the
      outcome being purification of the soul and the resultant judgment after life to
      be directed to heaven or hell. The Muslim goal is to live and die in accordance
      with God's will, as revealed in the Qur'an and practiced by the Prophet.
FAU - Baddarni, Kassim
AU  - Baddarni K
AD  - l-Taj for Health and Heritage, PO Box 85, Arraba 30812, Israel. altaj@013.net
LA  - eng
PT  - Journal Article
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
SB  - IM
MH  - Attitude to Health
MH  - *Cultural Competency
MH  - Humans
MH  - *Islam
EDAT- 2010/04/01 00:00
MHDA- 2016/04/23 06:00
CRDT- 2010/07/02 06:00
PHST- 2010/07/02 06:00 [entrez]
PHST- 2010/04/01 00:00 [pubmed]
PHST- 2016/04/23 06:00 [medline]
AID - 25177 [pii]
PST - ppublish
SO  - Asian Pac J Cancer Prev. 2010;11 Suppl 1:107-12.


PMID- 20590358
OWN - NLM
STAT- MEDLINE
DCOM- 20160422
LR  - 20220410
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Linking)
VI  - 11 Suppl 1
DP  - 2010
TI  - Pain relief is a human right.
PG  - 97-101
AB  - For centuries, medical and surgical treatment has emphasized saving the life of
      the patient rather than ameliorating the patient's pain, particularly when there 
      were few options for the latter. Today at the dawn of the 21st century, the best 
      available evidence indicates a major gap between an increasingly understanding of
      the pathophysiology of pain and widespread inadequacy of its treatment.
      Epidemiologic evidence has proven that chronic pain is a widespread public health
      issue. Studies of cancer patients' pain control consistently reveal that up to
      half of patients receive inadequate analgesia and 30% do not receive appropriate 
      drugs for their pain. Equally, for patients suffering HIV/AIDS, 60%-100% will
      experience pain at some stage in their illness. In the developed world, this gap 
      has prompted a series of declarations and actions by national and international
      bodies advocating better pain control. One response to the worldwide
      undertreatment of pain has been to promote the concept that pain relief is a
      public health issue of such critical importance as to constitute an international
      imperative and fundamental human right. The importance of pain relief as the core
      of the medical ethic is clear. Pain clinicians promote the status of pain
      management beyond that of appropriate clinical practice or even an ethic of good 
      medicine. They advocate a paradigm shift in the medical professions' perspective 
      on pain management, from simply good practice to an imperative founded on patient
      rights. There is a need to promote policies which create conditions where human
      beings can bear even incurable illnesses and death in a dignified manner. This
      must help health professionals or lay groups to initiate a powerful agenda to
      reform local statutes. The essential components of such legislation are: 1.
      Reasonable pain management is a right. 2. Doctors have a duty to listen to and
      reasonably respond to a patient's report of pain. 3. Provision of necessary pain 
      relief is immune from potential legal liability. 4. Doctors who are notable or
      willing to ensure adequate analgesia must refer to a colleague who has this
      expertise. 5. Pain management must be a compulsory component of continuing
      medical education. For too long, pain and its management have been prisoners of
      myth, irrationality, ignorance, and cultural bias. We are confident that the Pain
      Relief and Palliative Care Working Group under the auspices of the Lebanese
      Cancer Society is the main promoter of Palliative Care in Lebanon whose main goal
      is to relieve suffering and improve quality of life of the cancer patients, and
      advocate pain relief as a human right.
FAU - Daher, Michel
AU  - Daher M
AD  - Department of Surgery, Saint George Hospital, University Medical Center, Beirut, 
      Lebanon. mndaher@inco.com.lb
LA  - eng
PT  - Journal Article
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
SB  - IM
MH  - Human Rights
MH  - Humans
MH  - Neoplasms
MH  - Pain
MH  - *Pain Management
MH  - Palliative Care
MH  - *Quality of Life
EDAT- 2010/04/01 00:00
MHDA- 2016/04/23 06:00
CRDT- 2010/07/02 06:00
PHST- 2010/07/02 06:00 [entrez]
PHST- 2010/04/01 00:00 [pubmed]
PHST- 2016/04/23 06:00 [medline]
AID - 25175 [pii]
PST - ppublish
SO  - Asian Pac J Cancer Prev. 2010;11 Suppl 1:97-101.


PMID- 20590349
OWN - NLM
STAT- MEDLINE
DCOM- 20160422
LR  - 20220408
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Linking)
VI  - 11 Suppl 1
DP  - 2010
TI  - Religion, medicine and spirituality: what we know, what we don't know and what we
      do.
PG  - 45-9
AB  - Religion and spirituality have been linked to medicine and to healing for
      centuries. However, in the early 1900's the Flexner report noted that there was
      no place for religion in medicine; that medicine was strictly a scientific field,
      not a theological or philosophical one. In the mid to the latter 1900's there
      were several lay movements that started emphasized the importance of religion,
      spirituality and medicine. Lay religious movements found spiritual practices and 
      beliefs to be important in how people cope with suffering and find inner healing 
      even in the midst of incurable illness. The rise of Complementary and Alternative
      Medicine as well as the Hospice movements also influenced attention on the
      spiritual aspect of medicine. The Hospice movement, founded by Dr. Cecily
      Saunders, described the concept of "total pain"--i.e. the biopsychosocial and
      spiritual aspects of pain and suffering. Since the 1960's there has been
      increased research done in the area of religion and health and spirituality and
      health. Most of the studies are association studies which demonstrate and
      association of religious or spiritual beliefs and practices and some healthcare
      outcomes. More recently, studies on meditation have demonstrated significant
      improvement in health care outcomes and suggest meditation as a therapeutic
      modality. There are also numerous surveys that demonstrate patient need for
      having spirituality integrated into their care. Finally, a recent study
      demonstrated that patients with advanced illness who have spiritual care have
      better quality of life, increased utilization of hospice and less aggressive care
      at the end of life. In spite of all these studies, we still do not have a
      biological evidence base for mechanisms of beliefs and practices. There is
      considerable controversy over whether spirituality and religion can or even
      should be measured as criteria for integration into clinical care. Many believe
      that healthcare professionals have an ethical obligation to attend to all
      dimensions of a person's suffering, including the psychosocial as well as the
      spiritual and that ethical obligation is sufficient to require integration of
      spirituality into clinical care. Over the last twenty years, there has been an
      increase in the number of required courses in spirituality and medicine in US
      medical schools giving rise to a new field of medicine. In February of 2009, a
      national consensus conference developed spiritual care guidelines for
      interprofessional clinical spiritual care. These guidelines as well as the
      educational advances, research and ethical principles have supported the newly
      developing field of spirituality and health.
FAU - Puchalski, Christina Maria
AU  - Puchalski CM
AD  - Departments of Medicine and Health Sciences, The George Washington University
      School of Medicine and Health Sciences, Health Management and Leadership, The
      George Washington University School of Public Health, Washington, DC, USA.
      hcscmp@gwumc.edu
LA  - eng
PT  - Journal Article
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
SB  - IM
MH  - Hospice Care
MH  - Hospices
MH  - Humans
MH  - *Quality of Life
MH  - Religion
MH  - *Spirituality
MH  - Surveys and Questionnaires
EDAT- 2010/04/01 00:00
MHDA- 2016/04/23 06:00
CRDT- 2010/07/02 06:00
PHST- 2010/07/02 06:00 [entrez]
PHST- 2010/04/01 00:00 [pubmed]
PHST- 2016/04/23 06:00 [medline]
AID - 25168 [pii]
PST - ppublish
SO  - Asian Pac J Cancer Prev. 2010;11 Suppl 1:45-9.


PMID- 20352548
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20151119
IS  - 1464-5351 (Electronic)
IS  - 1369-1058 (Linking)
VI  - 12
IP  - 7
DP  - 2010 Oct
TI  - Male and female genital cutting among Southern Thailand's Muslims: rituals,
      biomedical practice and local discourses.
PG  - 725-38
LID - 10.1080/13691051003683109 [doi]
AB  - This paper explores how local people in a province in southern Thailand perceive 
      the practice of male and female genital cutting. In order to understand the
      importance placed on these practices, a comparison is drawn between the two and
      also between the male circumcision and the Buddhist ordination of monks as rites 
      of passage. Discourses on the exposure or concealment of male and female bodies, 
      respectively, witness to the relevance of both the local political-historical
      context and biomedical hegemony to gendered bodies. The comparisons evince the
      need to reflect upon the theoretical and ethical implications of studying genital
      cutting and focusing exclusively on one of the two practices rather than, as this
      paper claims to be necessary, considering them as inextricably connected.
FAU - Merli, Claudia
AU  - Merli C
AD  - Department of Anthropology, Durham University, Durham, UK.
      claudia.merli@durham.ac.uk
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Cult Health Sex
JT  - Culture, health & sexuality
JID - 100883416
SB  - IM
MH  - Buddhism
MH  - *Ceremonial Behavior
MH  - Child
MH  - Circumcision, Female/*methods
MH  - Circumcision, Male/*methods
MH  - Culture
MH  - Female
MH  - Focus Groups
MH  - Humans
MH  - *Islam
MH  - Male
MH  - Politics
MH  - Practice Patterns, Physicians'/*statistics & numerical data
MH  - Thailand
EDAT- 2010/03/31 06:00
MHDA- 2011/01/07 06:00
CRDT- 2010/03/31 06:00
PHST- 2010/03/31 06:00 [entrez]
PHST- 2010/03/31 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
AID - 920436091 [pii]
AID - 10.1080/13691051003683109 [doi]
PST - ppublish
SO  - Cult Health Sex. 2010 Oct;12(7):725-38. doi: 10.1080/13691051003683109.


PMID- 20352056
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 1050-8422 (Print)
IS  - 1050-8422 (Linking)
VI  - 20
IP  - 2
DP  - 2010 Mar 19
TI  - Strategies in Forecasting Outcomes in Ethical Decision-making: Identifying and
      Analyzing the Causes of the Problem.
PG  - 110-127
AB  - This study examined the role of key causal analysis strategies in forecasting and
      ethical decision-making. Undergraduate participants took on the role of the key
      actor in several ethical problems and were asked to identify and analyze the
      causes, forecast potential outcomes, and make a decision about each problem. Time
      pressure and analytic mindset were manipulated while participants worked through 
      these problems. The results indicated that forecast quality was associated with
      decision ethicality, and the identification of the critical causes of the problem
      was associated with both higher quality forecasts and higher ethicality of
      decisions. Neither time pressure nor analytic mindset impacted forecasts or
      ethicality of decisions. Theoretical and practical implications of these findings
      are discussed.
FAU - Beeler, Cheryl K
AU  - Beeler CK
AD  - The University of Oklahoma.
FAU - Antes, Alison L
AU  - Antes AL
FAU - Wang, Xiaoqian
AU  - Wang X
FAU - Caughron, Jared J
AU  - Caughron JJ
FAU - Thiel, Chase E
AU  - Thiel CE
FAU - Mumford, Michael D
AU  - Mumford MD
LA  - eng
GR  - R01 NR010341/NR/NINR NIH HHS/United States
GR  - R01 NR010341-02/NR/NINR NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Ethics Behav
JT  - Ethics & behavior
JID - 9102086
PMC - PMC2844648
MID - NIHMS179456
EDAT- 2010/03/31 06:00
MHDA- 2010/03/31 06:01
CRDT- 2010/03/31 06:00
PHST- 2010/03/31 06:00 [entrez]
PHST- 2010/03/31 06:00 [pubmed]
PHST- 2010/03/31 06:01 [medline]
AID - 10.1080/10508421003595935 [doi]
PST - ppublish
SO  - Ethics Behav. 2010 Mar 19;20(2):110-127. doi: 10.1080/10508421003595935.


PMID- 20351652
OWN - NLM
STAT- MEDLINE
DCOM- 20100730
LR  - 20151119
IS  - 1536-0210 (Electronic)
IS  - 0020-9996 (Linking)
VI  - 45
IP  - 5
DP  - 2010 May
TI  - Gadofosveset-enhanced magnetic resonance imaging of human carotid atherosclerotic
      plaques: a proof-of-concept study.
PG  - 275-81
LID - 10.1097/RLI.0b013e3181d5466b [doi]
AB  - OBJECTIVE: To investigate the potential of gadofosveset-enhanced MR imaging for
      the characterization of human carotid atherosclerotic plaques. MATERIALS AND
      METHODS: Sixteen (9 symptomatic, 7 asymptomatic) patients with 70% to 99% carotid
      stenosis (according to NASCET criteria) were included (13 men, 3 women, mean age 
      67.6 years). All patients underwent baseline precontrast MR imaging of the
      carotid plaque. Immediately after completion of the baseline examination, 0.03
      mmol/kg gadofosveset was administered. At 24 hours postinjection, the acquisition
      was repeated. Twelve patients were scheduled for carotid endarterectomy. Carotid 
      endarterectomy specimens were HE-, CD31-, CD68-, and albumin-stained to correlate
      signal enhancement with plaque composition, intraplaque microvessel density, and 
      macrophage and albumin content. A random intercept model was used to compare
      signal enhancement between symptomatic and asymptomatic patients, adjusting for
      size of various plaque components. This study was approved by the institutional
      medical ethics committee. All participants gave written informed consent.
      RESULTS: Signal enhancement (SE) of the plaque was significantly higher in
      symptomatic patients compared with asymptomatic patients (median log SE 0.182 vs.
      -0.109, respectively, P < 0.001). A positive association (as expressed by a
      regression coefficient beta = 0.0035) was found between signal enhancement on the
      log scale and intraplaque albumin content (P = 0.038). There was no association
      between signal enhancement and various other plaque components. CONCLUSION: In
      this study, the potential of gadofosveset-enhanced human carotid plaque MR
      imaging for identification of high-risk plaques was demonstrated. Signal
      enhancement of the plaque after administration of gadofosveset was associated
      with differences in intraplaque albumin content. Although promising, we emphasize
      that these results are based on a small patient population. Larger prospective
      studies are warranted.
FAU - Lobbes, Marc B I
AU  - Lobbes MB
AD  - Department of Radiology, Cardiovascular Research Institute Maastricht (CARIM),
      Maastricht University Medical Center, Maastricht, The Netherlands.
      marclobbes@planet.nl
FAU - Heeneman, Sylvia
AU  - Heeneman S
FAU - Passos, Valeria Lima
AU  - Passos VL
FAU - Welten, Rob
AU  - Welten R
FAU - Kwee, Robert M
AU  - Kwee RM
FAU - van der Geest, Rob J
AU  - van der Geest RJ
FAU - Wiethoff, Andrea J
AU  - Wiethoff AJ
FAU - Caravan, Peter
AU  - Caravan P
FAU - Misselwitz, Bernd
AU  - Misselwitz B
FAU - Daemen, Mat J A P
AU  - Daemen MJ
FAU - van Engelshoven, Jos M A
AU  - van Engelshoven JM
FAU - Leiner, Tim
AU  - Leiner T
FAU - Kooi, Marianne E
AU  - Kooi ME
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Invest Radiol
JT  - Investigative radiology
JID - 0045377
RN  - 0 (Albumins)
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - AU0V1LM3JT (Gadolinium)
RN  - XM33Q67UVH (gadofosveset trisodium)
SB  - IM
MH  - Aged
MH  - Albumins/analysis
MH  - Carotid Artery Diseases/*diagnosis
MH  - Carotid Stenosis/*diagnosis
MH  - *Contrast Media
MH  - Endarterectomy, Carotid
MH  - Female
MH  - *Gadolinium
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - *Organometallic Compounds
EDAT- 2010/03/31 06:00
MHDA- 2010/07/31 06:00
CRDT- 2010/03/31 06:00
PHST- 2010/03/31 06:00 [entrez]
PHST- 2010/03/31 06:00 [pubmed]
PHST- 2010/07/31 06:00 [medline]
AID - 10.1097/RLI.0b013e3181d5466b [doi]
PST - ppublish
SO  - Invest Radiol. 2010 May;45(5):275-81. doi: 10.1097/RLI.0b013e3181d5466b.


PMID- 20351011
OWN - NLM
STAT- MEDLINE
DCOM- 20100427
LR  - 20100812
IS  - 1098-4275 (Electronic)
IS  - 0031-4005 (Linking)
VI  - 125
IP  - 4
DP  - 2010 Apr
TI  - Policy statement--pediatric organ donation and transplantation.
PG  - 822-8
LID - 10.1542/peds.2010-0081 [doi]
AB  - Pediatric organ donation and organ transplantation can have a significant
      life-extending benefit to the young recipients of these organs and a high
      emotional impact on donor and recipient families. Pediatricians, pediatric
      medical specialists, and pediatric transplant surgeons need to be better
      acquainted with evolving national strategies that involve organ procurement and
      organ transplantation to help acquaint families with the benefits and risks of
      organ donation and transplantation. Efforts of pediatric professionals are needed
      to shape public policies to provide a system in which procurement, distribution, 
      and cost are fair and equitable to children and adults. Major issues of concern
      are availability of and access to donor organs; oversight and control of the
      process; pediatric medical and surgical consultation and continued care
      throughout the organ-donation and transplantation process; ethical, social,
      financial, and follow-up issues; insurance-coverage issues; and public awareness 
      of the need for organ donors of all ages.
CN  - Committee on Hospital Care, Section on Surgery, and Section on Critical Care
LA  - eng
PT  - Journal Article
DEP - 20100329
PL  - United States
TA  - Pediatrics
JT  - Pediatrics
JID - 0376422
SB  - IM
CIN - Pediatrics. 2010 Aug;126(2):e489-91; author reply e492. PMID: 20679309
CIN - Pediatrics. 2010 Aug;126(2):e491-2; author reply e492. PMID: 20679310
CIN - Pediatrics. 2010 Aug;126(2):e491; author reply e492. PMID: 20679311
MH  - Age Factors
MH  - *Health Policy
MH  - Humans
MH  - Organ Transplantation/methods/*standards
MH  - Pediatrics/methods/*standards
MH  - Physicians/standards
MH  - Societies, Medical/*standards
MH  - Tissue Donors
MH  - Tissue and Organ Procurement/methods/*standards
MH  - United States
IR  - Eichner JM
FIR - Eichner, Jerrold M
IR  - Chitkara MB
FIR - Chitkara, Maribeth B
IR  - Lye PS
FIR - Lye, Patricia S
IR  - Melzer SM
FIR - Melzer, Sanford M
IR  - Mirkinson LJ
FIR - Mirkinson, Laura J
IR  - Pearson-Shaver AL
FIR - Pearson-Shaver, Anthony L
IR  - Warner B
FIR - Warner, Brad
IR  - Brandt M
FIR - Brandt, Mary
IR  - Holcomb GW 3rd
FIR - Holcomb, George W 3rd
IR  - Lally K
FIR - Lally, Kevin
IR  - Rescorla F
FIR - Rescorla, Frederick
IR  - Shamberger R
FIR - Shamberger, Robert
IR  - Ricketts R
FIR - Ricketts, Richard
IR  - Vernon DD
FIR - Vernon, Donald D
IR  - Conway EE Jr
FIR - Conway, Edward E Jr
IR  - Lieh-Lai M
FIR - Lieh-Lai, Mary
IR  - Mink RB
FIR - Mink, Richard B
IR  - Montgomery V
FIR - Montgomery, Vicki
IR  - Salerno RA
FIR - Salerno, Richard A
IR  - Zabrocki LA
FIR - Zabrocki, Luke A
IR  - Ackerman AD
FIR - Ackerman, Alice D
EDAT- 2010/03/31 06:00
MHDA- 2010/04/28 06:00
CRDT- 2010/03/31 06:00
PHST- 2010/03/31 06:00 [entrez]
PHST- 2010/03/31 06:00 [pubmed]
PHST- 2010/04/28 06:00 [medline]
AID - peds.2010-0081 [pii]
AID - 10.1542/peds.2010-0081 [doi]
PST - ppublish
SO  - Pediatrics. 2010 Apr;125(4):822-8. doi: 10.1542/peds.2010-0081. Epub 2010 Mar 29.


PMID- 20351010
OWN - NLM
STAT- MEDLINE
DCOM- 20100427
LR  - 20220330
IS  - 1098-4275 (Electronic)
IS  - 0031-4005 (Linking)
VI  - 125
IP  - 4
DP  - 2010 Apr
TI  - Clinical report--guidelines for the ethical conduct of studies to evaluate drugs 
      in pediatric populations.
PG  - 850-60
LID - 10.1542/peds.2010-0082 [doi]
AB  - The proper ethical conduct of studies to evaluate drugs in children is of
      paramount importance to all those involved in these types of studies. This report
      is an updated revision to the previously published guidelines from the American
      Academy of Pediatrics in 1995. Since the previous publication, there have been
      great strides made in the science and ethics of studying drugs in children. There
      have also been numerous legislative and regulatory advancements that have
      promoted the study of drugs in children while simultaneously allowing for the
      protection of this particularly vulnerable group. This report summarizes these
      changes and advances and provides a framework from which to guide and monitor the
      ethical conduct of studies to evaluate drugs in children.
FAU - Shaddy, Robert E
AU  - Shaddy RE
FAU - Denne, Scott C
AU  - Denne SC
CN  - Committee on Drugs and Committee on Pediatric Research
LA  - eng
PT  - Journal Article
DEP - 20100329
PL  - United States
TA  - Pediatrics
JT  - Pediatrics
JID - 0376422
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Child
MH  - Clinical Trials as Topic/ethics/standards
MH  - Drug Evaluation/*ethics/standards
MH  - Humans
MH  - Informed Consent/ethics/standards
MH  - Pediatrics/*ethics/standards
MH  - *Pharmaceutical Preparations/standards
MH  - Practice Guidelines as Topic/*standards
MH  - Research Subjects
IR  - Snodgrass WR
FIR - Snodgrass, Wayne R
IR  - Frattarelli DA
FIR - Frattarelli, Daniel A C
IR  - Galinkin JL
FIR - Galinkin, Jeffrey L
IR  - Hegenbarth MA
FIR - Hegenbarth, Mary A
IR  - Hudak ML
FIR - Hudak, Mark L
IR  - Knight ME
FIR - Knight, Matthew E
IR  - Shaddy RE
FIR - Shaddy, Robert E
IR  - Denne SC
FIR - Denne, Scott C
IR  - Bauer AJ
FIR - Bauer, Andrew J
IR  - deCastro Cabana M
FIR - deCastro Cabana, Michael
IR  - Cheng TL
FIR - Cheng, Tina L
IR  - Flores G
FIR - Flores, Glenn
IR  - Notterman DA
FIR - Notterman, Daniel A
EDAT- 2010/03/31 06:00
MHDA- 2010/04/28 06:00
CRDT- 2010/03/31 06:00
PHST- 2010/03/31 06:00 [entrez]
PHST- 2010/03/31 06:00 [pubmed]
PHST- 2010/04/28 06:00 [medline]
AID - peds.2010-0082 [pii]
AID - 10.1542/peds.2010-0082 [doi]
PST - ppublish
SO  - Pediatrics. 2010 Apr;125(4):850-60. doi: 10.1542/peds.2010-0082. Epub 2010 Mar
      29.


PMID- 20351009
OWN - NLM
STAT- MEDLINE
DCOM- 20100427
LR  - 20100402
IS  - 1098-4275 (Electronic)
IS  - 0031-4005 (Linking)
VI  - 125
IP  - 4
DP  - 2010 Apr
TI  - Policy statement--health equity and children's rights.
PG  - 838-49
LID - 10.1542/peds.2010-0235 [doi]
AB  - Many children in the United States fail to reach their full health and
      developmental potential. Disparities in their health and well-being result from
      the complex interplay of multiple social and environmental determinants that are 
      not adequately addressed by current standards of pediatric practice or public
      policy. Integrating the principles and practice of child health equity-children's
      rights, social justice, human capital investment, and health equity ethics-into
      pediatrics will address the root causes of child health disparities. Promoting
      the principles and practice of equity-based clinical care, child advocacy, and
      child- and family-centered public policy will help to ensure that social and
      environmental determinants contribute positively to the health and well-being of 
      children. The American Academy of Pediatrics and pediatricians can move the
      national focus from documenting child health disparities to advancing the
      principles and practice of child health equity and, in so doing, influence the
      worldwide practice of pediatrics and child health. All pediatricians, including
      primary care practitioners and medical and surgical subspecialists, can
      incorporate these principles into their practice of pediatrics and child health. 
      Integration of these principles into competency-based training and board
      certification will secure their assimilation into all levels of pediatric
      practice.
CN  - Council on Community Pediatrics and Committee on Native American Child Health
LA  - eng
PT  - Journal Article
DEP - 20100329
PL  - United States
TA  - Pediatrics
JT  - Pediatrics
JID - 0376422
SB  - IM
MH  - Child
MH  - Child Advocacy/economics/*standards
MH  - *Health Policy/economics
MH  - Healthcare Disparities/economics/*standards
MH  - Humans
MH  - Pediatrics/*standards
MH  - Societies, Medical/*standards
MH  - United States
IR  - Granado-Villar DC
FIR - Granado-Villar, Deise C
IR  - Brown JM
FIR - Brown, Jeffrey M
IR  - Cotton WH
FIR - Cotton, William H
IR  - Madry Gaines BM
FIR - Madry Gaines, Beverly M
IR  - Gambon TB
FIR - Gambon, Thresia B
IR  - Gitterman BA
FIR - Gitterman, Benjamin A
IR  - Gorski PA
FIR - Gorski, Peter A
IR  - Kraft CA
FIR - Kraft, Colleen A
IR  - Marino RV
FIR - Marino, Ronald V
IR  - Paz-Soldan GJ
FIR - Paz-Soldan, Gonzalo J
IR  - Zind B
FIR - Zind, Barbara
IR  - Moore KR
FIR - Moore, Kelly R
IR  - Bell JT
FIR - Bell, Joseph T
IR  - Etzel RA
FIR - Etzel, Ruth Ann
IR  - Hoffman BD
FIR - Hoffman, Benjamin D
IR  - Ponder SW
FIR - Ponder, Stephen W
IR  - Redding MM
FIR - Redding, Mark M
IR  - Waldron DB
FIR - Waldron, Debra B
EDAT- 2010/03/31 06:00
MHDA- 2010/04/28 06:00
CRDT- 2010/03/31 06:00
PHST- 2010/03/31 06:00 [entrez]
PHST- 2010/03/31 06:00 [pubmed]
PHST- 2010/04/28 06:00 [medline]
AID - peds.2010-0235 [pii]
AID - 10.1542/peds.2010-0235 [doi]
PST - ppublish
SO  - Pediatrics. 2010 Apr;125(4):838-49. doi: 10.1542/peds.2010-0235. Epub 2010 Mar
      29.


PMID- 20349764
OWN - NLM
STAT- MEDLINE
DCOM- 20100504
LR  - 20100330
IS  - 0883-5381 (Print)
IS  - 0883-5381 (Linking)
VI  - 25
IP  - 2
DP  - 2010 Mar-Apr
TI  - Boundary issues in rural America. Overlapping relationships create ethical
      challenges for rural healthcare professionals.
PG  - 54, 56-7
FAU - Nelson, William A
AU  - Nelson WA
AD  - Dartmouth Medical School, Hanover, NH, USA. william.a.nelson@dartmouth.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Healthc Exec
JT  - Healthcare executive
JID - 8612808
MH  - Conflict of Interest
MH  - Humans
MH  - Professional-Patient Relations/*ethics
MH  - Rural Health Services/*ethics
MH  - Rural Population
MH  - United States
EDAT- 2010/03/31 06:00
MHDA- 2010/05/05 06:00
CRDT- 2010/03/31 06:00
PHST- 2010/03/31 06:00 [entrez]
PHST- 2010/03/31 06:00 [pubmed]
PHST- 2010/05/05 06:00 [medline]
PST - ppublish
SO  - Healthc Exec. 2010 Mar-Apr;25(2):54, 56-7.


PMID- 20349361
OWN - NLM
STAT- MEDLINE
DCOM- 20101129
LR  - 20220318
IS  - 1424-3997 (Electronic)
IS  - 0036-7672 (Linking)
VI  - 140
DP  - 2010
TI  - Retrospective research: What are the ethical and legal requirements?
PG  - w13041
LID - 10.4414/smw.2010.13041 [doi]
LID - 2010;140:w13041 [pii]
AB  - Retrospective research is conducted on already available data and/or biologic
      material. Whether such research requires that patients specifically consent to
      the use of "their" data continues to stir controversy. From a legal and ethical
      point of view, it depends on several factors. The main criteria to be considered 
      are whether the data or the sample is anonymous, whether the researcher is the
      one who collected it and whether the patient was told of the possible research
      use. In Switzerland, several laws delineate the procedure to be followed. The
      definition of "anonymous" is open to some interpretation. In addition, it is
      debatable whether consent waivers that are legally admissible for data extend to 
      research involving human biological samples. In a few years, a new Swiss federal 
      law on human research could clarify the regulatory landscape. Meanwhile,
      hospital-internal guidelines may impose stricter conditions than required by
      federal or cantonal law. Conversely, Swiss and European ethical texts may suggest
      greater flexibility and call for a looser interpretation of existing laws. The
      present article provides an overview of the issues for physicians, scientists,
      ethics committee members and policy makers involved in retrospective research in 
      Switzerland. It aims at provoking more open discussions of the regulatory
      problems and possible future legal and ethical solutions.
FAU - Junod, V
AU  - Junod V
AD  - Faculty of Business and Economics, University of Lausanne, and Faculty of Law,
      Geneva, Switzerland.
FAU - Elger, B
AU  - Elger B
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20100725
PL  - Switzerland
TA  - Swiss Med Wkly
JT  - Swiss medical weekly
JID - 100970884
SB  - IM
MH  - Biomedical Research/*ethics/*legislation & jurisprudence
MH  - *Ethics, Research
MH  - Guidelines as Topic
MH  - Humans
MH  - Informed Consent/ethics/legislation & jurisprudence
MH  - Presumed Consent/ethics/legislation & jurisprudence
MH  - *Retrospective Studies
MH  - Switzerland
EDAT- 2010/03/30 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/03/30 06:00
PHST- 2010/03/30 06:00 [entrez]
PHST- 2010/03/30 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - smw-12972 [pii]
AID - 10.4414/smw.2010.13041 [doi]
PST - epublish
SO  - Swiss Med Wkly. 2010 Jul 25;140:w13041. doi: 10.4414/smw.2010.13041. eCollection 
      2010.


PMID- 20349214
OWN - NLM
STAT- MEDLINE
DCOM- 20100708
LR  - 20211020
IS  - 1543-706X (Electronic)
IS  - 1071-2690 (Linking)
VI  - 46
IP  - 3-4
DP  - 2010 Apr
TI  - Establishment and characterization of human embryonic stem cell lines, Turkey
      perspectives.
PG  - 345-55
LID - 10.1007/s11626-010-9299-x [doi]
AB  - Human embryonic stem cells (hESC), which are derived from the inner cell mass
      (ICM) of blastocyst stage embryos, are of great importance because of their
      unpredictable two unique features: their differentiation ability into all types
      of cells derived from three germ layers and their potentially unlimited capacity 
      of self renewing with stable karyotype. These distinguished properties make hESC 
      very promising cell source for regenerative medicine, tissue replacement
      therapies, and drug screening studies as well as genomics. However, due to the
      several technical problems, such as risk of teratoma formation, immune response, 
      and unknown genetic pathways for lineage specific differentiation, and ethical
      drawbacks of their using in clinical treatments, hESC researches are still
      waiting to advance beyond to animal trials and drug studies. During the last
      decade, more than 300 new hESC lines have been derived and published by
      researchers worldwide. However, despite their similar well-known unique
      properties, recent studies reported that hESC lines have very individual
      properties and are differed from each other with regards to their differentiation
      ability and gene expression profiles. Therefore, all hESC lines should be
      characterized in detail and then registered in a stem cell bank for generating
      global database. In this report, the characteristic of hESC lines, which were
      established in Istanbul Memorial Hospital between 2003 and 2005, and derivation
      methods were described in detail to inform researchers and to facilitate new
      prospective cooperative studies.
FAU - Candan, Zafer Nihat
AU  - Candan ZN
AD  - Istanbul Memorial Hospital, ART & Reproductive Genetics Unit, Piyale Pasa
      Bulvari, Okmeydani, 34385 Istanbul, Turkey. zafercandan@gmail.com
FAU - Kahraman, Semra
AU  - Kahraman S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100327
PL  - Germany
TA  - In Vitro Cell Dev Biol Anim
JT  - In vitro cellular & developmental biology. Animal
JID - 9418515
RN  - 0 (Biomarkers)
SB  - IM
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Cell Culture Techniques/*methods
MH  - Cell Differentiation
MH  - Cell Line
MH  - Cell Separation
MH  - Embryo, Mammalian/cytology
MH  - Embryonic Stem Cells/*cytology/metabolism
MH  - Fibroblasts/cytology
MH  - Humans
MH  - Karyotyping
MH  - Mice
MH  - Myocytes, Cardiac/cytology/ultrastructure
MH  - Turkey
EDAT- 2010/03/30 06:00
MHDA- 2010/07/09 06:00
CRDT- 2010/03/30 06:00
PHST- 2009/04/02 00:00 [received]
PHST- 2010/01/16 00:00 [accepted]
PHST- 2010/03/30 06:00 [entrez]
PHST- 2010/03/30 06:00 [pubmed]
PHST- 2010/07/09 06:00 [medline]
AID - 10.1007/s11626-010-9299-x [doi]
PST - ppublish
SO  - In Vitro Cell Dev Biol Anim. 2010 Apr;46(3-4):345-55. doi:
      10.1007/s11626-010-9299-x. Epub 2010 Mar 27.


PMID- 20349037
OWN - NLM
STAT- MEDLINE
DCOM- 20100908
LR  - 20211020
IS  - 1432-1238 (Electronic)
IS  - 0342-4642 (Linking)
VI  - 36
IP  - 6
DP  - 2010 Jun
TI  - Triaging for adult critical care in the event of overwhelming need.
PG  - 1076-82
LID - 10.1007/s00134-010-1862-0 [doi]
AB  - INTRODUCTION: Predictions of the need for critical care within the H1N1 influenza
      pandemic suggested overwhelming need beyond potential resources, necessitating
      rationing of care via triaging. METHOD: The triage model described was derived
      from informed discourse within a conjoined NHS and University Clinical Ethics
      Committee, supplemented by specialists in intensive care and infectious diseases.
      THE MODEL: The triage methodology described is justified ethically primarily upon
      'utilitarian' principles within an aggregate public health model, with additional
      reference to 'fairness'. Advantages of such a model, which partially suspends
      usual clinical judgment applied to individuals in favour of also utilizing organ 
      failure scores, include minimization of aggregate influenza morbidity and
      mortality, and minimization of psychological stress upon staff making triaging
      decisions. Legally, in England and Wales, the model is uncontentious as regards
      rationing of admission to critical care; however, the law adopts 'futility' as
      the core justification for withdrawal of treatment, applied to the individual,
      thus failing to allow for rationing through triaging individuals out of critical 
      care in the interest of other patients with better chances of survival. There is 
      therefore a mismatch between a clinically and ethically acceptable model of
      triaging, based upon a public health approach, and the law, based upon the
      paradigm of the individual patient. CONCLUSION: The good fortune that the H1N1
      pandemic was less severe than predicted, allowing time for calm consideration,
      debate and decision making about what model of triaging should be adopted
      whenever it might be necessary in the future. It is in the interest of the health
      of the nation, and government, to decide upon a critical care triaging model
      while there is not an imminent health service crisis.
FAU - Eastman, Nigel
AU  - Eastman N
AD  - St George's Clinical Ethics Committee, St George's University of London, London, 
      SW17 0RE, UK. neastman@sgul.ac.uk
FAU - Philips, Barbara
AU  - Philips B
FAU - Rhodes, Andrew
AU  - Rhodes A
LA  - eng
PT  - Journal Article
DEP - 20100327
PL  - United States
TA  - Intensive Care Med
JT  - Intensive care medicine
JID - 7704851
SB  - IM
MH  - Adult
MH  - Critical Illness/*therapy
MH  - Emergency Service, Hospital
MH  - *Health Services Needs and Demand
MH  - Human Rights
MH  - Humans
MH  - *Influenza A Virus, H1N1 Subtype
MH  - Influenza, Human/*diagnosis/therapy
MH  - Models, Theoretical
MH  - Politics
MH  - Surge Capacity
MH  - Triage/*ethics/legislation & jurisprudence
MH  - United Kingdom
EDAT- 2010/03/30 06:00
MHDA- 2010/09/09 06:00
CRDT- 2010/03/30 06:00
PHST- 2009/10/07 00:00 [received]
PHST- 2010/02/24 00:00 [accepted]
PHST- 2010/03/30 06:00 [entrez]
PHST- 2010/03/30 06:00 [pubmed]
PHST- 2010/09/09 06:00 [medline]
AID - 10.1007/s00134-010-1862-0 [doi]
PST - ppublish
SO  - Intensive Care Med. 2010 Jun;36(6):1076-82. doi: 10.1007/s00134-010-1862-0. Epub 
      2010 Mar 27.


PMID- 20348870
OWN - NLM
STAT- MEDLINE
DCOM- 20100416
LR  - 20211020
IS  - 1940-087X (Electronic)
IS  - 1940-087X (Linking)
IP  - 37
DP  - 2010 Mar 26
TI  - Primary human bronchial epithelial cells grown from explants.
LID - 10.3791/1789 [doi]
LID - 1789 [pii]
AB  - Human bronchial epithelial cells are needed for cell models of disease and to
      investigate the effect of excipients and pharmacologic agents on the function and
      structure of human epithelial cells. Here we describe in detail the method of
      growing bronchial epithelial cells from bronchial airway tissue that is harvested
      by the surgeon at the times of lung surgery (e.g. lung cancer or lung volume
      reduction surgery). With ethics approval and informed consent, the surgeon takes 
      what is needed for pathology and provides us with a bronchial portion that is
      remote from the diseased areas. The tissue is then used as a source of explants
      that can be used for growing primary bronchial epithelial cells in culture.
      Bronchial segments about 0.5-1cm long and < or =1cm in diameter are rinsed with
      cold EBSS and excess parenchymal tissue is removed. Segments are cut open and
      minced into 2-3mm(3) pieces of tissue. The pieces are used as a source of primary
      cells. After coating 100mm culture plates for 1-2 hr with a combination of
      collagen (30 microg/ml), fibronectin (10 microg/ml), and BSA (10 microg/ml), the 
      plates are scratched in 4-5 areas and tissue pieces are placed in the scratched
      areas, then culture medium (DMEM/Ham F-12 with additives) suitable for epithelial
      cell growth is added and plates are placed in an incubator at 37 degrees C in 5% 
      CO(2) humidified air. The culture medium is changed every 3-4 days. The
      epithelial cells grow from the pieces forming about 1.5 cm diameter rings in 3-4 
      weeks. Explants can be re-used up to 6 times by moving them into new pre-coated
      plates. Cells are lifted using trypsin/EDTA, pooled, counted, and re-plated in
      T75 Cell Bind flasks to increase their numbers. T75 flasks seeded with 2-3
      million cells grow to 80% confluence in 4 weeks. Expanded primary human
      epithelial cells can be cultured and allowed to differentiate on air-liquid
      interface. Methods described here provide an abundant source of human bronchial
      epithelial cells from freshly isolated tissues and allow for studying these cells
      as models of disease and for pharmacology and toxicology screening.
FAU - Yaghi, Asma
AU  - Yaghi A
AD  - Medicine, Faculty of Health Sciences, McMaster University. ayaghi@stjosham.on.ca
FAU - Zaman, Aisha
AU  - Zaman A
FAU - Dolovich, Myrna
AU  - Dolovich M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Video-Audio Media
DEP - 20100326
PL  - United States
TA  - J Vis Exp
JT  - Journal of visualized experiments : JoVE
JID - 101313252
SB  - IM
MH  - Bronchi/*cytology
MH  - Cytological Techniques/*methods
MH  - Epithelial Cells/*cytology
MH  - Humans
PMC - PMC3168214
EDAT- 2010/03/30 06:00
MHDA- 2010/04/17 06:00
CRDT- 2010/03/30 06:00
PHST- 2010/03/30 06:00 [entrez]
PHST- 2010/03/30 06:00 [pubmed]
PHST- 2010/04/17 06:00 [medline]
AID - 1789 [pii]
AID - 10.3791/1789 [doi]
PST - epublish
SO  - J Vis Exp. 2010 Mar 26;(37). pii: 1789. doi: 10.3791/1789.


PMID- 20348215
OWN - NLM
STAT- MEDLINE
DCOM- 20100826
LR  - 20191210
IS  - 1546-8364 (Electronic)
IS  - 1059-8405 (Linking)
VI  - 26
IP  - 3
DP  - 2010 Jun
TI  - Ethical principles as a guide in implementing policies for the management of food
      allergies in schools.
PG  - 183-93
LID - 10.1177/1059840510364844 [doi]
AB  - Food allergy in children is a growing public health problem that carries a
      significant risk of anaphylaxis such that schools and child care facilities have 
      enacted emergency preparedness policies for anaphylaxis and methods to prevent
      the inadvertent consumption of allergens. However, studies indicate that many
      facilities are poorly prepared to handle the advent of anaphylaxis and policies
      for the prevention of allergen exposure are missing essential components.
      Furthermore, certain policies are inappropriate because they are blatantly
      discriminatory. This article aims to provide further guidance for school health
      officials involved in creating food allergy policies. By structuring policies
      around ethical principles of confidentiality and anonymity, fairness, avoiding
      stigmatization, and empowerment, policy makers gain another method to support
      better policy making. The main ethical principles discussed are adapted from key 
      values in the bioethics and public health ethics literatures and will be framed
      within the specific context of food allergy policies for schools.
FAU - Behrmann, Jason
AU  - Behrmann J
AD  - Bioethics Programs, Universite de Montreal, Montreal, Canada.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100326
PL  - United States
TA  - J Sch Nurs
JT  - The Journal of school nursing : the official publication of the National
      Association of School Nurses
JID - 9206498
MH  - Child
MH  - Confidentiality/ethics
MH  - Food Hypersensitivity/epidemiology/*prevention & control
MH  - Food Services/ethics
MH  - Guideline Adherence
MH  - Humans
MH  - Incidence
MH  - Menu Planning
MH  - Nurse's Role
MH  - Organizational Policy
MH  - Patient Advocacy/ethics
MH  - Policy Making
MH  - Power, Psychological
MH  - Practice Guidelines as Topic
MH  - *Principle-Based Ethics
MH  - Risk Factors
MH  - Safety Management/ethics/organization & administration
MH  - *School Health Services/ethics/organization & administration
MH  - *School Nursing/ethics/organization & administration
MH  - Social Justice/ethics
MH  - Stereotyping
EDAT- 2010/03/30 06:00
MHDA- 2010/08/27 06:00
CRDT- 2010/03/30 06:00
PHST- 2010/03/30 06:00 [entrez]
PHST- 2010/03/30 06:00 [pubmed]
PHST- 2010/08/27 06:00 [medline]
AID - 1059840510364844 [pii]
AID - 10.1177/1059840510364844 [doi]
PST - ppublish
SO  - J Sch Nurs. 2010 Jun;26(3):183-93. doi: 10.1177/1059840510364844. Epub 2010 Mar
      26.


PMID- 20348083
OWN - NLM
STAT- MEDLINE
DCOM- 20120524
LR  - 20100329
IS  - 1544-5208 (Electronic)
IS  - 0278-2715 (Linking)
VI  - 29
IP  - 2
DP  - 2010 Feb
TI  - Ethical funding for HIV/AIDS: 3 caveats.
PG  - 333; author reply 333
LID - 10.1377/hlthaff.2010.0063 [doi]
FAU - Van Puymbroeck, Rudolf V
AU  - Van Puymbroeck RV
LA  - eng
PT  - Letter
PL  - United States
TA  - Health Aff (Millwood)
JT  - Health affairs (Project Hope)
JID - 8303128
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/*economics
MH  - *Developed Countries
MH  - Financial Support/*ethics
MH  - Financing, Organized/ethics
MH  - HIV Infections/*economics
MH  - Humans
EDAT- 2010/03/30 06:00
MHDA- 2012/05/25 06:00
CRDT- 2010/03/30 06:00
PHST- 2010/03/30 06:00 [entrez]
PHST- 2010/03/30 06:00 [pubmed]
PHST- 2012/05/25 06:00 [medline]
AID - 29/2/333-b [pii]
AID - 10.1377/hlthaff.2010.0063 [doi]
PST - ppublish
SO  - Health Aff (Millwood). 2010 Feb;29(2):333; author reply 333. doi:
      10.1377/hlthaff.2010.0063.


PMID- 20347731
OWN - NLM
STAT- MEDLINE
DCOM- 20100406
LR  - 20100329
IS  - 1879-1190 (Electronic)
IS  - 1072-7515 (Linking)
VI  - 210
IP  - 4
DP  - 2010 Apr
TI  - Informed consent: cultural and religious issues associated with the use of
      allogeneic and xenogeneic mesh products.
PG  - 402-10
LID - 10.1016/j.jamcollsurg.2009.12.001 [doi]
AB  - BACKGROUND: Our aim was to investigate the views of major religions and cultural 
      groups regarding the use of allogeneic and xenogeneic mesh for soft tissue
      repair. STUDY DESIGN: We contacted representatives from Judaism, Islam, Buddhism,
      Hinduism, Scientology, and Christianity (Baptists, Methodists, Seventh-Day
      Adventists, Catholics, Lutherans, Church of Jesus Christ of Latter-Day Saints,
      Evangelical, and Jehovah's Witnesses). We also contacted American Vegan and
      People for the Ethical Treatment of Animals (PETA). Standardized questionnaires
      were distributed to the religious and cultural authorities. Questions solicited
      views on the consumption of beef and pork products and the acceptability of
      human-, bovine-, or porcine-derived acellular grafts. RESULTS: Dietary
      restrictions among Jews and Muslims do not translate to tissue implantation
      restriction. Approximately 50% of Seventh-day Adventists and 40% of Buddhists
      practice vegetarianism, which may translate into a refusal of the use of
      xenogeneic tissue. Some Hindus categorically prohibit the use of human tissue and
      animal products; others allow the donation and receipt of human organs and
      tissues. PETA is opposed to all uses of animals, but not to human acellular
      grafts or organ transplantation. Some vegans prefer allogeneic to xenogeneic
      tissue. Allogeneic and xenogeneic acellular grafts are acceptable among
      Scientologists, Baptists, Lutherans, Evangelicals, and Catholics. Methodists,
      Jehovah's Witnesses, and The Church of Jesus Christ of Latter-Day Saints leave
      the decision up to the individual. CONCLUSIONS: Knowledge of religious and
      cultural preferences regarding biologic mesh assists the surgeon in obtaining a
      culturally sensitive informed consent for procedures involving acellular
      allogeneic or xenogeneic grafts.
CI  - Copyright (c) 2010 American College of Surgeons. Published by Elsevier Inc. All
      rights reserved.
FAU - Jenkins, Eric D
AU  - Jenkins ED
AD  - Department of Surgery, Washington University School of Medicine, St Louis, MO
      63110, USA.
FAU - Yip, Michael
AU  - Yip M
FAU - Melman, Lora
AU  - Melman L
FAU - Frisella, Margaret M
AU  - Frisella MM
FAU - Matthews, Brent D
AU  - Matthews BD
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Coll Surg
JT  - Journal of the American College of Surgeons
JID - 9431305
SB  - IM
MH  - Adult
MH  - Aged
MH  - Animal Welfare
MH  - Christianity
MH  - *Cultural Characteristics
MH  - Diet, Vegetarian
MH  - Female
MH  - Hinduism
MH  - Humans
MH  - *Informed Consent
MH  - Islam
MH  - Judaism
MH  - Male
MH  - Middle Aged
MH  - *Religion and Medicine
MH  - *Surgical Mesh
MH  - *Transplantation, Heterologous
MH  - *Transplantation, Homologous
MH  - United States
EDAT- 2010/03/30 06:00
MHDA- 2010/04/07 06:00
CRDT- 2010/03/30 06:00
PHST- 2009/10/27 00:00 [received]
PHST- 2009/12/01 00:00 [revised]
PHST- 2009/12/02 00:00 [accepted]
PHST- 2010/03/30 06:00 [entrez]
PHST- 2010/03/30 06:00 [pubmed]
PHST- 2010/04/07 06:00 [medline]
AID - S1072-7515(09)01617-2 [pii]
AID - 10.1016/j.jamcollsurg.2009.12.001 [doi]
PST - ppublish
SO  - J Am Coll Surg. 2010 Apr;210(4):402-10. doi: 10.1016/j.jamcollsurg.2009.12.001.


PMID- 20347668
OWN - NLM
STAT- MEDLINE
DCOM- 20100611
LR  - 20100329
IS  - 1879-1131 (Electronic)
IS  - 0738-081X (Linking)
VI  - 28
IP  - 2
DP  - 2010 Mar 4
TI  - The medical expert witness: legal and ethical issues.
PG  - 240-2
LID - 10.1016/j.clindermatol.2009.05.018 [doi]
FAU - Hirsch, Paul
AU  - Hirsch P
AD  - Department of Dermatology, University of Southern California, Keck School of
      Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA. phskindoc@aol.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Dermatol
JT  - Clinics in dermatology
JID - 8406412
SB  - IM
MH  - Dermatology/standards
MH  - *Ethics, Medical
MH  - Expert Testimony/*ethics/*legislation & jurisprudence/standards
MH  - Humans
MH  - Malpractice/*legislation & jurisprudence
MH  - Practice Guidelines as Topic
MH  - Professional Practice/*ethics
MH  - Referral and Consultation/ethics
MH  - United States
EDAT- 2010/03/30 06:00
MHDA- 2010/06/12 06:00
CRDT- 2010/03/30 06:00
PHST- 2010/03/30 06:00 [entrez]
PHST- 2010/03/30 06:00 [pubmed]
PHST- 2010/06/12 06:00 [medline]
AID - S0738-081X(09)00133-3 [pii]
AID - 10.1016/j.clindermatol.2009.05.018 [doi]
PST - ppublish
SO  - Clin Dermatol. 2010 Mar 4;28(2):240-2. doi: 10.1016/j.clindermatol.2009.05.018.


PMID- 20347616
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20100914
IS  - 1873-4898 (Electronic)
IS  - 1477-5131 (Linking)
VI  - 6
IP  - 5
DP  - 2010 Oct
TI  - Placebo-controlled trials in pediatric urology: a cautionary view from an ethical
      perspective.
PG  - 435-42
LID - 10.1016/j.jpurol.2010.02.208 [doi]
AB  - The ethical dispute regarding placebo-controlled trials is discussed in this
      review. Important issues, such as clinical equipoise, fiduciary obligation and
      middle ground theory, are examined in the context of pediatric urology clinical
      research. After reviewing the literature, the authors summarize specific
      indications for placebo-controlled trials in pediatric urology, and emphasize
      that physicians have ethical and moral obligations to patients, in the sense that
      one should carefully plan and conduct such trials in order to gain clinically
      important information without exposing children to undue risks.
CI  - Copyright (c) 2010 Journal of Pediatric Urology Company. Published by Elsevier
      Ltd. All rights reserved.
FAU - Braga, Luis H P
AU  - Braga LH
AD  - Division of Pediatric Urology, McMaster's Children Hospital, McMaster University,
      1200 Main Street West, 4E19, Hamilton, ON L8N 3Z5, Canada. braga@mcmaster.ca
FAU - Bagli, Darius J
AU  - Bagli DJ
FAU - Lorenzo, Armando J
AU  - Lorenzo AJ
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100329
PL  - England
TA  - J Pediatr Urol
JT  - Journal of pediatric urology
JID - 101233150
RN  - 0 (Placebos)
SB  - IM
MH  - *Ethics, Research
MH  - Helsinki Declaration
MH  - Humans
MH  - Pediatrics
MH  - Placebos
MH  - Randomized Controlled Trials as Topic/*ethics
MH  - Urology
EDAT- 2010/03/30 06:00
MHDA- 2011/01/07 06:00
CRDT- 2010/03/30 06:00
PHST- 2009/10/07 00:00 [received]
PHST- 2010/02/16 00:00 [accepted]
PHST- 2010/03/30 06:00 [entrez]
PHST- 2010/03/30 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
AID - S1477-5131(10)00253-6 [pii]
AID - 10.1016/j.jpurol.2010.02.208 [doi]
PST - ppublish
SO  - J Pediatr Urol. 2010 Oct;6(5):435-42. doi: 10.1016/j.jpurol.2010.02.208. Epub
      2010 Mar 29.


PMID- 20347601
OWN - NLM
STAT- MEDLINE
DCOM- 20100817
LR  - 20220309
IS  - 1532-2165 (Electronic)
IS  - 1078-5884 (Linking)
VI  - 39
IP  - 6
DP  - 2010 Jun
TI  - Information communicated with patients in decision making about their abdominal
      aortic aneurysm.
PG  - 708-13
LID - 10.1016/j.ejvs.2010.02.012 [doi]
AB  - OBJECTIVES: To explore what kind of information surgeons communicate with
      patients diagnosed with an abdominal aortic aneurysm, and if the information
      provided regarding the disorder and treatment options available complies with
      legal requirements. METHODS: Dutch vascular surgeons sound-recorded consultations
      with their patients. Recordings were scored using a checklist based on ethical
      considerations and five statutory categories of information on: (1) the disorder,
      (2) procedure and aim of surgery, (3) consequences and risks of surgery, (4)
      watchful observation and (5) individual prognosis regarding state of health. Each
      category was represented by several information items, which were scored
      dichotomously ('not mentioned' or 'mentioned'). A category was considered
      sufficiently addressed if at least one of its items was mentioned. RESULTS:
      Thirty-five consultations were recorded (13 patients with aneurysmal diameter
      <5.5 cm and 22 with diameter >or=5.5 cm). In a minority of recordings, all five
      categories were addressed: 1/13 (8%) and 9/22 (41%), respectively. None of the
      information items was discussed consistently in every recording. Although most
      patients were informed about the proposed treatment option (11/13; 85% and 19/22;
      86%), the alternative treatment option was mentioned only occasionally (4/13; 31%
      and 14/22; 64%). CONCLUSIONS: Patients with an abdominal aneurysm are informed
      inconsistently about their disorder and treatment options. Information is often
      less than that legally required. This may hinder shared decision making.
CI  - Copyright (c) 2010 European Society for Vascular Surgery. Published by Elsevier
      Ltd. All rights reserved.
FAU - Knops, A M
AU  - Knops AM
AD  - Department of Quality Assurance and Process Innovation, Academic Medical Center, 
      Amsterdam, The Netherlands.
FAU - Ubbink, D T
AU  - Ubbink DT
FAU - Legemate, D A
AU  - Legemate DA
FAU - de Haes, J C J M
AU  - de Haes JC
FAU - Goossens, A
AU  - Goossens A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20100329
PL  - England
TA  - Eur J Vasc Endovasc Surg
JT  - European journal of vascular and endovascular surgery : the official journal of
      the European Society for Vascular Surgery
JID - 9512728
SB  - IM
MH  - Aged
MH  - Aortic Aneurysm, Abdominal/diagnosis/*surgery
MH  - *Communication
MH  - *Decision Making
MH  - Decision Support Techniques
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - *Informed Consent
MH  - Male
MH  - Netherlands
MH  - *Patient Participation
MH  - *Physician-Patient Relations
MH  - Prospective Studies
MH  - *Referral and Consultation
EDAT- 2010/03/30 06:00
MHDA- 2010/08/18 06:00
CRDT- 2010/03/30 06:00
PHST- 2009/12/24 00:00 [received]
PHST- 2010/02/19 00:00 [accepted]
PHST- 2010/03/30 06:00 [entrez]
PHST- 2010/03/30 06:00 [pubmed]
PHST- 2010/08/18 06:00 [medline]
AID - S1078-5884(10)00118-8 [pii]
AID - 10.1016/j.ejvs.2010.02.012 [doi]
PST - ppublish
SO  - Eur J Vasc Endovasc Surg. 2010 Jun;39(6):708-13. doi: 10.1016/j.ejvs.2010.02.012.
      Epub 2010 Mar 29.


PMID- 20347270
OWN - NLM
STAT- MEDLINE
DCOM- 20100730
LR  - 20220330
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Linking)
VI  - 119
IP  - 1-3
DP  - 2010 Jun
TI  - Who needs antipsychotic medication in the earliest stages of psychosis? A
      reconsideration of benefits, risks, neurobiology and ethics in the era of early
      intervention.
PG  - 1-10
LID - 10.1016/j.schres.2010.02.1071 [doi]
AB  - In recent years, early intervention services have attempted to identify people
      with a first episode of psychosis as early as possible, reducing the duration of 
      untreated psychosis and changing the timing of delivery of interventions. The
      logic of early intervention is based partly on accessing people in a more
      treatment responsive stage of illness in which psychosocial damage is less
      extensive, and partly on remediating a putatively active process of
      neuroprogression that leads to pathophysiological, symptomatic and structural
      changes, hence improving symptomatic and functional outcomes. However, as in
      other areas of health care, earlier identification of new patients may mean that 
      different treatment approaches are indicated. The corollary of early detection is
      that the sequence and complexion of treatment strategies for first episode
      psychosis has been revaluated. Examples include the minimal effective dosage of
      antipsychotic medication and the content of psychosocial interventions. With the 
      substantial reductions of DUP now seen in many early psychosis services, based on
      clinical staging and stepped care principles, it is even possible that the
      immediate introduction of antipsychotic medication may not be necessary for all
      first episode psychosis cases, but that potentially safer interventions, which
      may be more acceptable to many patients, such as comprehensive psychosocial
      intervention, may constitute effective treatment at least for a subgroup of
      patients. In this paper, we review this theoretical background and describe a
      randomised controlled trial currently underway at the Early Psychosis Prevention 
      and Intervention Centre (EPPIC) in Melbourne designed to test outcomes for first 
      episode psychosis patients in response to two different treatments: intensive
      psychosocial intervention plus antipsychotic medication versus intensive
      psychosocial intervention plus placebo. This is a theoretically and pragmatically
      novel study in that it will provide evidence as to whether intensive psychosocial
      intervention alone is sufficient for a subgroup of first episode psychosis
      patients in a specialised early intervention service, and provide a test of the
      heuristic clinical staging model. By experimentally manipulating duration of
      untreated psychosis, the study will also provide a methodologically strong test
      of the effect of delaying the introduction of antipsychotic medication, as well
      as helping to disentangle the effects of antipsychotic medications and the
      putative neurobiological processes associated with brain changes and symptom
      profiles in the early phase of psychotic disorders. The study has been carefully 
      crafted to satisfy critical ethical demands in this challenging research domain.
CI  - Crown Copyright (c) 2010. Published by Elsevier B.V. All rights reserved.
FAU - Francey, S M
AU  - Francey SM
AD  - Orygen Youth Health, 35 Poplar Road Locked Bag 10, Parkville, Victoria 3052,
      Australia.
FAU - Nelson, B
AU  - Nelson B
FAU - Thompson, A
AU  - Thompson A
FAU - Parker, A G
AU  - Parker AG
FAU - Kerr, M
AU  - Kerr M
FAU - Macneil, C
AU  - Macneil C
FAU - Fraser, R
AU  - Fraser R
FAU - Hughes, F
AU  - Hughes F
FAU - Crisp, K
AU  - Crisp K
FAU - Harrigan, S
AU  - Harrigan S
FAU - Wood, S J
AU  - Wood SJ
FAU - Berk, M
AU  - Berk M
FAU - McGorry, P D
AU  - McGorry PD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100326
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
RN  - 0 (Antipsychotic Agents)
SB  - IM
MH  - Antipsychotic Agents/*administration & dosage/adverse effects
MH  - Brain/drug effects/physiopathology
MH  - Cognitive Behavioral Therapy/*ethics
MH  - Combined Modality Therapy/ethics
MH  - Counseling/*ethics
MH  - Dose-Response Relationship, Drug
MH  - Early Diagnosis
MH  - Ethics, Medical
MH  - Family Therapy/*ethics
MH  - Humans
MH  - Outcome and Process Assessment, Health Care
MH  - Psychotic Disorders/diagnosis/*drug therapy/physiopathology
MH  - Randomized Controlled Trials as Topic
MH  - Risk Factors
MH  - Schizophrenia/diagnosis/*drug therapy/physiopathology
MH  - Secondary Prevention
MH  - Social Support
RF  - 140
EDAT- 2010/03/30 06:00
MHDA- 2010/07/31 06:00
CRDT- 2010/03/30 06:00
PHST- 2009/10/05 00:00 [received]
PHST- 2010/02/18 00:00 [revised]
PHST- 2010/02/26 00:00 [accepted]
PHST- 2010/03/30 06:00 [entrez]
PHST- 2010/03/30 06:00 [pubmed]
PHST- 2010/07/31 06:00 [medline]
AID - S0920-9964(10)01166-7 [pii]
AID - 10.1016/j.schres.2010.02.1071 [doi]
PST - ppublish
SO  - Schizophr Res. 2010 Jun;119(1-3):1-10. doi: 10.1016/j.schres.2010.02.1071. Epub
      2010 Mar 26.


PMID- 20346886
OWN - NLM
STAT- MEDLINE
DCOM- 20100715
LR  - 20100830
IS  - 1558-1527 (Electronic)
IS  - 1558-1527 (Linking)
VI  - 81
IP  - 4
DP  - 2010 Apr
TI  - Publication ethics.
PG  - 167-8
LID - 10.1016/j.optm.2010.02.005 [doi]
FAU - Freeman, Paul B
AU  - Freeman PB
LA  - eng
PT  - Editorial
PL  - United States
TA  - Optometry
JT  - Optometry (St. Louis, Mo.)
JID - 100912421
SB  - IM
CIN - Optometry. 2010 Sep;81(9):429. PMID: 20728819
MH  - Editorial Policies
MH  - Humans
MH  - *Peer Review, Research
MH  - *Periodicals as Topic
MH  - Retraction of Publication as Topic
MH  - Scientific Misconduct
EDAT- 2010/03/30 06:00
MHDA- 2010/07/16 06:00
CRDT- 2010/03/30 06:00
PHST- 2010/03/30 06:00 [entrez]
PHST- 2010/03/30 06:00 [pubmed]
PHST- 2010/07/16 06:00 [medline]
AID - S1529-1839(10)00069-2 [pii]
AID - 10.1016/j.optm.2010.02.005 [doi]
PST - ppublish
SO  - Optometry. 2010 Apr;81(4):167-8. doi: 10.1016/j.optm.2010.02.005.


PMID- 20346818
OWN - NLM
STAT- MEDLINE
DCOM- 20100511
LR  - 20220410
IS  - 1474-547X (Electronic)
IS  - 0140-6736 (Linking)
VI  - 375
IP  - 9720
DP  - 2010 Mar 27
TI  - Realignment of incentives for health-care providers in China.
PG  - 1120-30
LID - 10.1016/S0140-6736(10)60063-3 [doi]
AB  - Inappropriate incentives as part of China's fee-for-service payment system have
      resulted in rapid cost increase, inefficiencies, poor quality, unaffordable
      health care, and an erosion of medical ethics. To reverse these outcomes, a
      strategy of experimentation to realign incentives for providers with the social
      goals of improvement in quality and efficiency has been initiated in China. This 
      Review shows how lessons that have been learned from international experiences
      have been improved further in China by realignment of the incentives for
      providers towards prevention and primary care, and incorporation of a treatment
      protocol for hospital services. Although many experiments are new, preliminary
      evidence suggests a potential to produce savings in costs. However, because these
      experiments have not been scientifically assessed in China, evidence of their
      effects on quality and health outcome is largely missing. Although a reform of
      the provider's payment can be an effective short-term strategy, professional
      ethics need to be re-established and incentives changed to alter the profit
      motives of Chinese hospitals and physicians alike. When hospitals are given
      incentives to achieve maximum profit, incentives for hospitals and physicians
      must be separated.
CI  - Copyright 2010 Elsevier Ltd. All rights reserved.
FAU - Yip, Winnie Chi-Man
AU  - Yip WC
AD  - Department of Public Health, Oxford University, Oxford, UK.
      winnie.yip@dphpc.ox.ac.uk
FAU - Hsiao, William
AU  - Hsiao W
FAU - Meng, Qingyue
AU  - Meng Q
FAU - Chen, Wen
AU  - Chen W
FAU - Sun, Xiaoming
AU  - Sun X
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Lancet
JT  - Lancet (London, England)
JID - 2985213R
SB  - IM
MH  - China
MH  - Community Health Centers/economics/organization & administration
MH  - Delivery of Health Care/economics/*organization & administration
MH  - *Fee-for-Service Plans
MH  - *Health Care Reform
MH  - Health Services Misuse
MH  - Humans
MH  - Primary Health Care/economics/organization & administration
MH  - *Reimbursement, Incentive
RF  - 58
EDAT- 2010/03/30 06:00
MHDA- 2010/05/12 06:00
CRDT- 2010/03/30 06:00
PHST- 2010/03/30 06:00 [entrez]
PHST- 2010/03/30 06:00 [pubmed]
PHST- 2010/05/12 06:00 [medline]
AID - S0140-6736(10)60063-3 [pii]
AID - 10.1016/S0140-6736(10)60063-3 [doi]
PST - ppublish
SO  - Lancet. 2010 Mar 27;375(9720):1120-30. doi: 10.1016/S0140-6736(10)60063-3.


PMID- 20346605
OWN - NLM
STAT- MEDLINE
DCOM- 20100817
LR  - 20100514
IS  - 1879-1476 (Electronic)
IS  - 0385-8146 (Linking)
VI  - 37
IP  - 5
DP  - 2010 Oct
TI  - Impaired olfactory function in mice with allergic rhinitis.
PG  - 575-83
LID - 10.1016/j.anl.2009.12.004 [doi]
AB  - OBJECTIVE: It has been reported that olfactory function is impaired in patients
      with allergic rhinitis. However, the mechanism of olfactory dysfunction in
      allergic rhinitis remains poorly understood. Because of difficulties in obtaining
      and analyzing human olfactory mucosa due to both technical and ethical issues, an
      animal model needs to be established to clarify the mechanism of olfactory
      dysfunction in allergic rhinitis. The purpose of this study was to study
      olfactory function and changes in olfactory mucosa using allergic rhinitis mice. 
      METHODS: A model of allergic rhinitis mice with olfactory dysfunction was
      developed by sensitizing with ovalbumin (OVA), and intranasally challenging with 
      the same allergen. Olfactory function of mice with or without allergic rhinitis
      was assessed by odor detection ability test with cycloheximide and local field
      potential (LFP) with 1-octanal. We also evaluated histological changes in the
      olfactory mucosa of allergic rhinitis mice by both light and electron microscopy.
      RESULTS: Both of odor detection ability test and LFP showed that olfactory
      function was impaired in mice with allergic rhinitis, but not in mice without
      allergic rhinitis. Histopathological findings showed prominent infiltration of
      eosinophils, plasma cells, neutrophils, mast cells, and macrophages in lamina
      propria of olfactory mucosa of mice with allergic rhinitis, although infiltration
      of these cells was not seen in control mice. Allergic rhinitis also increased the
      number and size of glands in olfactory mucosa, suggesting an elevated amount of
      mucin in olfactory mucosa. CONCLUSION: This study showed for the first time that 
      mice with allergic rhinitis have impaired olfactory function, increased size and 
      number of olfactory glands, and infiltration of eosinophils, neutrophils, mast
      cells, plasma cells, and macrophages in the olfactory mucosa. This suggests that 
      allergic reactions are seen in olfactory mucosa of mice with allergic rhinitis,
      and that greater olfactory gland activity is associated with olfactory
      dysfunction. Also, this mouse model could provide an expedient system for
      analyzing mechanisms of olfactory dysfunction.
CI  - Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Ozaki, Shinya
AU  - Ozaki S
AD  - Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medical
      Science, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya,
      Aichi, 467-8602, Japan. sozaki@med.nagoya-cu.ac.jp
FAU - Toida, Kazunori
AU  - Toida K
FAU - Suzuki, Motohiko
AU  - Suzuki M
FAU - Nakamura, Yoshihisa
AU  - Nakamura Y
FAU - Ohno, Nobuaki
AU  - Ohno N
FAU - Ohashi, Taku
AU  - Ohashi T
FAU - Nakayama, Meiho
AU  - Nakayama M
FAU - Hamajima, Yuki
AU  - Hamajima Y
FAU - Inagaki, Akira
AU  - Inagaki A
FAU - Kitaoka, Kazuyoshi
AU  - Kitaoka K
FAU - Sei, Hiroyoshi
AU  - Sei H
FAU - Murakami, Shingo
AU  - Murakami S
LA  - eng
PT  - Journal Article
DEP - 20100326
PL  - Netherlands
TA  - Auris Nasus Larynx
JT  - Auris, nasus, larynx
JID - 7708170
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - Antibody Specificity/immunology
MH  - Eosinophils/immunology/pathology
MH  - Immunoenzyme Techniques
MH  - Immunoglobulin E/blood
MH  - Macrophages/immunology/pathology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Microscopy, Electron, Transmission
MH  - Neutrophils/immunology/pathology
MH  - Olfactory Mucosa/*immunology/*pathology
MH  - Ovalbumin/immunology
MH  - Plasma Cells/immunology/pathology
MH  - Rhinitis, Allergic, Perennial/*immunology/pathology
MH  - Sensory Thresholds/*physiology
MH  - Smell/*physiology
EDAT- 2010/03/30 06:00
MHDA- 2010/08/18 06:00
CRDT- 2010/03/30 06:00
PHST- 2009/08/06 00:00 [received]
PHST- 2009/11/03 00:00 [revised]
PHST- 2009/12/11 00:00 [accepted]
PHST- 2010/03/30 06:00 [entrez]
PHST- 2010/03/30 06:00 [pubmed]
PHST- 2010/08/18 06:00 [medline]
AID - S0385-8146(10)00026-X [pii]
AID - 10.1016/j.anl.2009.12.004 [doi]
PST - ppublish
SO  - Auris Nasus Larynx. 2010 Oct;37(5):575-83. doi: 10.1016/j.anl.2009.12.004. Epub
      2010 Mar 26.


PMID- 20346442
OWN - NLM
STAT- MEDLINE
DCOM- 20100607
LR  - 20220310
IS  - 1879-1883 (Electronic)
IS  - 0002-9610 (Linking)
VI  - 199
IP  - 5
DP  - 2010 May
TI  - Medical tourism in bariatric surgery.
PG  - 604-8
LID - 10.1016/j.amjsurg.2010.01.002 [doi]
AB  - BACKGROUND: The number of Canadians who self-refer for bariatric surgery outside 
      of Canada or to private clinics within Canada remains undefined. The outcomes
      from this questionable practice have not been evaluated systematically to date.
      METHODS: We completed a chart review of known cases referred to our center for
      complications related to medical tourism and bariatric surgery. RESULTS: We
      present a series of patients who have experienced complications because of
      medical tourism for bariatric surgery and required urgent surgical management at 
      a tertiary care center within Canada. Complications have resulted from 3 commonly
      used procedures: adjustable gastric banding, gastric sleeve resection, and
      Roux-en-Y gastric bypass. CONCLUSIONS: Because of this review, we propose that a 
      medical tourism approach to the surgical management of obesity-a chronic
      disease-is inappropriate and raises clear ethical and moral issues.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Birch, Daniel W
AU  - Birch DW
AD  - Center for the Advancement of Minimally Invasive Surgery, Royal Alexandra
      Hospital, 10240 Kingsway, Edmonton, Alberta, T5H 3V9 Canada. dbirch@ualberta.ca
FAU - Vu, Lan
AU  - Vu L
FAU - Karmali, Shahzeer
AU  - Karmali S
FAU - Stoklossa, Carlene Johnson
AU  - Stoklossa CJ
FAU - Sharma, Arya M
AU  - Sharma AM
LA  - eng
PT  - Journal Article
DEP - 20100325
PL  - United States
TA  - Am J Surg
JT  - American journal of surgery
JID - 0370473
SB  - IM
MH  - Adult
MH  - Bariatric Surgery/adverse effects/methods
MH  - Body Mass Index
MH  - Canada
MH  - Female
MH  - Follow-Up Studies
MH  - Gastric Bypass/*adverse effects/methods
MH  - Gastroplasty
MH  - Humans
MH  - Laparoscopy/*adverse effects/methods
MH  - Medical Tourism/*statistics & numerical data/trends
MH  - Middle Aged
MH  - Obesity, Morbid/diagnosis/*surgery
MH  - Postoperative Complications/epidemiology/*surgery
MH  - Reoperation
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Sampling Studies
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2010/03/30 06:00
MHDA- 2010/06/09 06:00
CRDT- 2010/03/30 06:00
PHST- 2009/11/07 00:00 [received]
PHST- 2010/01/12 00:00 [revised]
PHST- 2010/01/12 00:00 [accepted]
PHST- 2010/03/30 06:00 [entrez]
PHST- 2010/03/30 06:00 [pubmed]
PHST- 2010/06/09 06:00 [medline]
AID - S0002-9610(10)00036-X [pii]
AID - 10.1016/j.amjsurg.2010.01.002 [doi]
PST - ppublish
SO  - Am J Surg. 2010 May;199(5):604-8. doi: 10.1016/j.amjsurg.2010.01.002. Epub 2010
      Mar 25.


PMID- 20346287
OWN - NLM
STAT- MEDLINE
DCOM- 20100607
LR  - 20100329
IS  - 0767-0974 (Print)
IS  - 0767-0974 (Linking)
VI  - 26
IP  - 3
DP  - 2010 Mar
TI  - [Ethics and organ retrievals on deceased donors after cardiac stop].
PG  - 328-30
LID - 10.1051/medsci/2010263328 [doi]
FAU - Antoine, Corinne
AU  - Antoine C
AD  - Pole strategie greffe, Direction medicale et scientifique de l'Agence de la
      biomedecine, Agence de la biomedecine, 1, avenue du Stade de France, 93212
      Saint-Denis la Plaine Cedex, France. corinne.antoine@biomedecine.fr
FAU - Tenaillon, Alain
AU  - Tenaillon A
LA  - fre
PT  - Journal Article
TT  - Ethique et prelevements d'organes sur donneurs decedes apres arret cardiaque.
PL  - France
TA  - Med Sci (Paris)
JT  - Medecine sciences : M/S
JID - 8710980
SB  - IM
MH  - *Death, Sudden, Cardiac
MH  - *Ethics, Medical
MH  - Heart Arrest
MH  - Humans
MH  - Informed Consent
MH  - *Tissue Donors
MH  - Tissue and Organ Harvesting/*standards
EDAT- 2010/03/30 06:00
MHDA- 2010/06/09 06:00
CRDT- 2010/03/30 06:00
PHST- 2010/03/30 06:00 [entrez]
PHST- 2010/03/30 06:00 [pubmed]
PHST- 2010/06/09 06:00 [medline]
AID - 00/00/0F/30/ [pii]
AID - 10.1051/medsci/2010263328 [doi]
PST - ppublish
SO  - Med Sci (Paris). 2010 Mar;26(3):328-30. doi: 10.1051/medsci/2010263328.


PMID- 20346192
OWN - NLM
STAT- MEDLINE
DCOM- 20110318
LR  - 20211028
IS  - 1469-8978 (Electronic)
IS  - 0033-2917 (Linking)
VI  - 41
IP  - 1
DP  - 2011 Jan
TI  - Regaining mental capacity for treatment decisions following psychiatric
      admission: a clinico-ethical study.
PG  - 119-28
LID - 10.1017/S0033291710000383 [doi]
AB  - BACKGROUND: Mental capacity is an emerging ethical legal concept in psychiatric
      settings but its relation to clinical parameters remains uncertain. We sought to 
      investigate the associations of regaining capacity to make treatment decisions
      following approximately 1 month of in-patient psychiatric treatment. METHOD: We
      followed up 115 consecutive patients admitted to a psychiatric hospital who were 
      judged to lack capacity to make treatment decisions at the point of
      hospitalization. We were primarily interested in whether the diagnosis of
      schizophrenia and schizoaffective disorder associated with reduced chances of
      regaining capacity compared with other diagnoses and whether affective symptoms
      on admission associated with increased chances of regaining capacity. In
      addition, we examined how change in insight was associated with regaining
      capacity in schizophrenia, bipolar affective disorder (BPAD)-mania, and
      depression. RESULTS: We found evidence that the category of 'schizophrenia or
      schizoaffective disorder' associated with not regaining capacity at 1 month
      compared with BPAD-mania [odds ratio (OR) 3.62, 95% confidence intervals (CI)
      1.13-11.6] and depression (OR 5.35, 95% CI 1.47-9.55) and that affective symptoms
      on admission associated with regaining capacity (OR 1.23, 95% CI 1.02-1.48). In
      addition, using an interaction model, we found some evidence that gain in insight
      may not be a good indicator of regaining capacity in patients with depression
      compared with patients with schizophrenia and BPAD-mania. CONCLUSIONS: We suggest
      that clinico-ethical studies using mental capacity provide a way of assessing the
      validity of nosological and other clinical concepts in psychiatry.
FAU - Owen, G S
AU  - Owen GS
AD  - Department of Psychological Medicine and Psychiatry, Institute of Psychiatry,
      King's College London, Western Education Centre, London, UK.
      Gareth.1.Owen@kcl.ac.uk
FAU - Ster, I Chis
AU  - Ster IC
FAU - David, A S
AU  - David AS
FAU - Szmukler, G
AU  - Szmukler G
FAU - Hayward, P
AU  - Hayward P
FAU - Richardson, G
AU  - Richardson G
FAU - Hotopf, M
AU  - Hotopf M
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100329
PL  - England
TA  - Psychol Med
JT  - Psychological medicine
JID - 1254142
SB  - IM
MH  - Adult
MH  - Bipolar Disorder/psychology/therapy
MH  - Confidence Intervals
MH  - Depressive Disorder, Major/psychology/therapy
MH  - Female
MH  - Humans
MH  - Inpatients/*psychology
MH  - Logistic Models
MH  - Male
MH  - Mental Competency/*psychology
MH  - Mental Disorders/*psychology/therapy
MH  - Odds Ratio
MH  - Psychiatric Department, Hospital/statistics & numerical data
MH  - Psychiatric Status Rating Scales
MH  - Psychotic Disorders/psychology/therapy
MH  - Remission Induction
MH  - Schizophrenia/therapy
MH  - Schizophrenic Psychology
MH  - Time Factors
PMC - PMC7611689
MID - EMS133891
EDAT- 2010/03/30 06:00
MHDA- 2011/03/19 06:00
CRDT- 2010/03/30 06:00
PHST- 2010/03/30 06:00 [entrez]
PHST- 2010/03/30 06:00 [pubmed]
PHST- 2011/03/19 06:00 [medline]
AID - S0033291710000383 [pii]
AID - 10.1017/S0033291710000383 [doi]
PST - ppublish
SO  - Psychol Med. 2011 Jan;41(1):119-28. doi: 10.1017/S0033291710000383. Epub 2010 Mar
      29.


PMID- 20346109
OWN - NLM
STAT- MEDLINE
DCOM- 20110914
LR  - 20211020
IS  - 1471-2458 (Electronic)
IS  - 1471-2458 (Linking)
VI  - 10
DP  - 2010 Mar 26
TI  - Do 'good values' lead to 'good' health-behaviours? Longitudinal associations
      between young people's values and later substance-use.
PG  - 165
LID - 10.1186/1471-2458-10-165 [doi]
AB  - BACKGROUND: Past studies have linked certain values (traditional vs.
      individualistic) with adolescent substance-use. The aims of this study are to
      replicate cross-sectional research linking values and adolescent substance-use
      and to determine if such values predict future substance-use. METHODS: A
      longitudinal school-based survey of 2196 young people (age 15) followed up in
      early adulthood (age 18/19). Participants provided data about their beliefs and
      values at age 15, and their substance-use (smoking, alcohol and drug-use) at ages
      15 and 18/19. In addition data were collected about their social background
      (gender, risk-taking, deprivation, religion, etc). RESULTS: Cross-sectionally,
      young people with anti-authority values were more likely to use various
      substances, e.g. 17-67% more likely to regularly smoke (daily), drink (most
      days), or use drugs (weekly) for each SD above typical levels. Adjusting for
      social background, associations were not substantially attenuated. However in the
      prospective analysis, adjusting for both background and substance-use at age 15, 
      only two (anti-authoritarian and work ethic) values were (marginally) associated 
      with substance-use at age 18/19. CONCLUSIONS: While we replicated results found
      in prior cross-sectional studies, evidence from this study does not support the
      argument that holding certain 'pro-social' or 'good' values substantively
      protects against later substance-use and challenges the likely effectiveness of
      values-based interventions in relation to later substance-use.
FAU - Young, Robert
AU  - Young R
AD  - MRC Social and Public Health Sciences Unit, University of Glasgow, 4 Lilybank
      Gardens, Glasgow G12 8RZ, UK. robert@sphsu.mrc.ac.uk
FAU - West, Patrick
AU  - West P
LA  - eng
GR  - MC_U130059818/MRC_/Medical Research Council/United Kingdom
GR  - MC_UP_A540_1022/MRC_/Medical Research Council/United Kingdom
GR  - U.1300.00.007/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100326
PL  - England
TA  - BMC Public Health
JT  - BMC public health
JID - 100968562
SB  - IM
MH  - Adolescent
MH  - Cross-Sectional Studies
MH  - Female
MH  - Follow-Up Studies
MH  - *Health Behavior
MH  - Humans
MH  - Life Style
MH  - Longitudinal Studies
MH  - Male
MH  - Psychometrics
MH  - Risk-Taking
MH  - Scotland
MH  - Sex Distribution
MH  - *Social Values
MH  - Students/*psychology/statistics & numerical data
MH  - Substance-Related Disorders/epidemiology/*psychology
MH  - Surveys and Questionnaires
MH  - Young Adult
PMC - PMC2864210
EDAT- 2010/03/30 06:00
MHDA- 2011/09/15 06:00
CRDT- 2010/03/30 06:00
PHST- 2009/10/01 00:00 [received]
PHST- 2010/03/26 00:00 [accepted]
PHST- 2010/03/30 06:00 [entrez]
PHST- 2010/03/30 06:00 [pubmed]
PHST- 2011/09/15 06:00 [medline]
AID - 1471-2458-10-165 [pii]
AID - 10.1186/1471-2458-10-165 [doi]
PST - epublish
SO  - BMC Public Health. 2010 Mar 26;10:165. doi: 10.1186/1471-2458-10-165.


PMID- 20346094
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1756-994X (Electronic)
IS  - 1756-994X (Linking)
VI  - 2
IP  - 3
DP  - 2010 Mar 24
TI  - Tailoring the process of informed consent in genetic and genomic research.
PG  - 20
LID - 10.1186/gm141 [doi]
AB  - Genomic science and associated technologies are facilitating an unprecedented
      rate of discovery of novel insights into the relationship between human genetic
      variation and health. The willingness of large numbers of individuals from
      different ethnic and cultural backgrounds to donate biological samples is one of 
      the major factors behind the success of the ongoing genomic revolution. Although 
      current informed consent documents and processes demonstrate a commitment to
      ensuring that study participants are well informed of the risks and benefits of
      participating in genomic studies, there continues to be a need to develop
      effective new approaches for adequately informing participants of the changing
      complexities of the scientific and ethical issues that arise in the conduct of
      genomics research. Examples of these complexities in genomic research include
      more widespread use of whole-genome sequencing technologies, broad sharing of
      individual-level data, evolving information technology, the growing demand for
      the return of genetic results to participants, and changing attitudes about
      privacy and the expansion of genomics studies to global populations representing 
      diverse cultural, linguistic and socio-economic backgrounds. We highlight and
      briefly discuss the importance of ten core scientific, cultural and social
      factors that are particularly relevant to tailoring informed consent in genomic
      research, and we draw attention to the need for the informed consent document and
      process to be responsive to the evolving nature of genomic research.
FAU - Rotimi, Charles N
AU  - Rotimi CN
AD  - Inherited Disease Research Branch, Center for Research on Genomics and Global
      Health, National Human Genome Research Institute, National Institutes of Health, 
      12 South Drive, Bethesda, MD 20892-5635, USA. rotimic@mail.nih.gov.
FAU - Marshall, Patricia A
AU  - Marshall PA
LA  - eng
PT  - Editorial
DEP - 20100324
PL  - England
TA  - Genome Med
JT  - Genome medicine
JID - 101475844
PMC - PMC2873798
EDAT- 2010/03/30 06:00
MHDA- 2010/03/30 06:01
CRDT- 2010/03/30 06:00
PHST- 2010/03/30 06:00 [entrez]
PHST- 2010/03/30 06:00 [pubmed]
PHST- 2010/03/30 06:01 [medline]
AID - gm141 [pii]
AID - 10.1186/gm141 [doi]
PST - epublish
SO  - Genome Med. 2010 Mar 24;2(3):20. doi: 10.1186/gm141.


PMID- 20346048
OWN - NLM
STAT- MEDLINE
DCOM- 20110131
LR  - 20101207
IS  - 1464-410X (Electronic)
IS  - 1464-4096 (Linking)
VI  - 106
IP  - 8
DP  - 2010 Oct
TI  - Improving informed consent for patients undergoing radical prostatectomy using
      multimedia techniques: a prospective randomized crossover study.
PG  - 1152-6
LID - 10.1111/j.1464-410X.2010.09309.x [doi]
AB  - OBJECTIVE: to compare the comprehension gained by standard consent (SC) vs a
      unique interactive multimedia presentation (IMP), for radical prostatectomy (RP),
      as informed consent for RP requires that the patient understands the procedure
      and potential complications. PATIENTS AND METHODS: forty patients undergoing RP
      were prospectively randomized to SC or IMP, followed by a 26-question test on
      critical aspects of the surgery and its implications. The groups were crossed
      over and re-tested, with a subsequent statistical analysis. SC involved typical
      verbal interaction and consultation with physicians and nurses, whilst the IMP
      provided consistent and animated information on these topics, and included
      multiple-choice questions probing understanding of key points. Progression
      through the IMP only occurred with correct responses; incorrect responses
      prompted a review of the information before repeating the question. Telephone
      interviews assessed usability, overall understanding, educational level and
      primary language. RESULTS: the patient groups had similar demographics. The IMP
      group (78%) had significantly higher knowledge test scores (P < 0.001) than the
      SC group (57%), suggesting a better understanding of the implications of surgery.
      This was maintained on crossover, with the SC group scores improving by 11%
      compared to testing before IMP (P < 0.001). The initial IMP group scores were
      unchanged on crossover and repeat testing (P < 0.05). CONCLUSION: IMP provides
      better patient understanding than SC for RP, by ensuring that the procedure and
      risks have been explained consistently, and by actively testing the patient. Such
      tools assist in obtaining ethical and legally informed consent, thus increasing
      patient knowledge whilst reducing patient anxiety and potential dissatisfaction
      or medico-legal consequences when less than ideal outcomes occur.
FAU - Gyomber, Dennis
AU  - Gyomber D
AD  - University of Melbourne, Department of Urology, Austin Health, Heidelberg,
      Australia.
FAU - Lawrentschuk, Nathan
AU  - Lawrentschuk N
FAU - Wong, Peter
AU  - Wong P
FAU - Parker, Frank
AU  - Parker F
FAU - Bolton, Damien M
AU  - Bolton DM
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - BJU Int
JT  - BJU international
JID - 100886721
SB  - IM
MH  - Decision Making, Computer-Assisted
MH  - Epidemiologic Methods
MH  - Humans
MH  - Informed Consent/*psychology
MH  - Male
MH  - Middle Aged
MH  - *Multimedia
MH  - Patient Education as Topic/*methods
MH  - Prostatectomy/*psychology
MH  - Prostatic Neoplasms/*psychology/surgery
EDAT- 2010/03/30 06:00
MHDA- 2011/02/01 06:00
CRDT- 2010/03/30 06:00
PHST- 2010/03/30 06:00 [entrez]
PHST- 2010/03/30 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
AID - BJU9309 [pii]
AID - 10.1111/j.1464-410X.2010.09309.x [doi]
PST - ppublish
SO  - BJU Int. 2010 Oct;106(8):1152-6. doi: 10.1111/j.1464-410X.2010.09309.x.


PMID- 20345984
OWN - NLM
STAT- MEDLINE
DCOM- 20100709
LR  - 20211020
IS  - 1365-2249 (Electronic)
IS  - 0009-9104 (Linking)
VI  - 160
IP  - 3
DP  - 2010 Jun
TI  - Activation of signal transducer and activator of transcription-1 (STAT-1) and
      differential expression of interferon-gamma and anti-inflammatory proteins in
      pelvic ileal pouches for ulcerative colitis and familial adenomatous polyposis.
PG  - 380-5
LID - 10.1111/j.1365-2249.2009.04088.x [doi]
AB  - Pouchitis after total rectocolectomy is the most common complication of
      ulcerative colitis (UC). The immunological mechanisms involved in the genesis of 
      pouchitis are unclear. Therefore, we evaluated the inflammatory activity in
      normal ileal pouch mucosa by determining signal transducers and activators of
      transcription (STAT-1) activation and cytokine expression in patients operated
      for UC and familial adenomatous polyposis (FAP). Eighteen asymptomatic patients, 
      who underwent total rectocolectomy and J pouch, were evaluated: nine with UC and 
      nine with FAP. The activation of STAT-1 and cytokine expression were determined
      by immunoblot of total protein extracts from pouch mucosal biopsies. The absence 
      of pouchitis was assessed by clinical, histological and endoscopic parameters,
      according to the Pouchitis Disease Activity Index. The patients were not
      receiving any medication. Analysis of variance (anova) and Tukey-Kramer's test
      were applied. The local ethical committee approved the study and informed consent
      was signed by all participants. STAT-1 activation was increased in UC when
      compared to FAP and controls (P < 0.05). Higher levels of interferon (IFN)-gamma 
      expression were observed in UC patients when compared to the control group (P <
      0.05), but were similar to FAP. In contrast, cytokine signalling (SOCS-3) and
      interleukin (IL)-10 expression were similar in all groups (P > 0.05). These
      findings could explain the higher susceptibility to this inflammatory
      complication in UC when compared to FAP. A tendency towards increased levels of
      IFN-gamma and STAT-1 in patients with UC, even without clinical and endoscopic
      evidence of pouchitis, was observed; studying inflammatory activity in
      asymptomatic ileal pouches may help understanding of the pathogenesis of
      pouchitis.
FAU - Leal, R F
AU  - Leal RF
AD  - Coloproctology Unit, Surgery Department, University of Campinas (UNICAMP),
      Medical School, Sao Paulo, Brazil.
FAU - Ayrizono, M L S
AU  - Ayrizono ML
FAU - Milanski, M
AU  - Milanski M
FAU - Coope, A
AU  - Coope A
FAU - Fagundes, J J
AU  - Fagundes JJ
FAU - Velloso, L A
AU  - Velloso LA
FAU - Coy, C S R
AU  - Coy CS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100316
PL  - England
TA  - Clin Exp Immunol
JT  - Clinical and experimental immunology
JID - 0057202
RN  - 0 (IL10 protein, human)
RN  - 0 (SOCS3 protein, human)
RN  - 0 (STAT1 Transcription Factor)
RN  - 0 (STAT1 protein, human)
RN  - 0 (Suppressor of Cytokine Signaling 3 Protein)
RN  - 0 (Suppressor of Cytokine Signaling Proteins)
RN  - 130068-27-8 (Interleukin-10)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Adenomatous Polyposis Coli/*immunology/metabolism/pathology/surgery
MH  - Adult
MH  - Colitis, Ulcerative/*immunology/metabolism/pathology/surgery
MH  - Female
MH  - Gene Expression Regulation/*immunology
MH  - Humans
MH  - Ileum/*immunology/metabolism/pathology/surgery
MH  - Interferon-gamma/biosynthesis/*immunology
MH  - Interleukin-10/biosynthesis/immunology
MH  - Intestinal Mucosa/*immunology/metabolism/pathology/surgery
MH  - Male
MH  - Middle Aged
MH  - Pouchitis/etiology/immunology/metabolism/pathology
MH  - STAT1 Transcription Factor/*immunology/metabolism
MH  - Suppressor of Cytokine Signaling 3 Protein
MH  - Suppressor of Cytokine Signaling Proteins/biosynthesis/immunology
PMC - PMC2883108
EDAT- 2010/03/30 06:00
MHDA- 2010/07/10 06:00
CRDT- 2010/03/30 06:00
PHST- 2010/03/30 06:00 [entrez]
PHST- 2010/03/30 06:00 [pubmed]
PHST- 2010/07/10 06:00 [medline]
AID - CEI4088 [pii]
AID - 10.1111/j.1365-2249.2009.04088.x [doi]
PST - ppublish
SO  - Clin Exp Immunol. 2010 Jun;160(3):380-5. doi: 10.1111/j.1365-2249.2009.04088.x.
      Epub 2010 Mar 16.


PMID- 20345832
OWN - NLM
STAT- MEDLINE
DCOM- 20100824
LR  - 20100526
IS  - 1365-2702 (Electronic)
IS  - 0962-1067 (Linking)
VI  - 19
IP  - 9-10
DP  - 2010 May
TI  - Care of acutely ill older patients in hospital: clinical decision-making.
PG  - 1252-60
LID - 10.1111/j.1365-2702.2009.03141.x [doi]
AB  - AIMS AND OBJECTIVES: The aim of this study was to investigate the nursing care of
      older hospitalised patients and how the nurses providing care understood the
      clinical decision-making around this care. BACKGROUND: One of the challenges
      confronting nurses is how best to manage the care required by increasing numbers 
      of older people with complex problems and illnesses being admitted to hospitals. 
      DESIGN: This qualitative study used multiple methods of data collection that
      included observations, interviews and, where needed, review of the hospital
      records of older patients. METHOD: Twenty-seven registered nurses participated
      from across five hospital units. Data were analysed thematically to understand
      how nurses cared for older patients. RESULTS: The interpretative analysis yielded
      three major themes that emerged in relation to nursing care of older patients:
      knowing about care; optionalising care; and blaming. Participants were
      knowledgeable and potentially competent in providing care required by older
      patients in hospital. However, they admitted that they optionalised care by
      making decisions about which patients to care for and how much care should be
      provided. Participants rationalised these decisions through laying blame on the
      hospital organisation, needing social time with colleagues and preferring
      medically oriented technical interventions. CONCLUSION: Nurses experienced
      tension between professional and ethical nursing responsibilities and the lack of
      challenge and reward associated with the care of this group of patients. They
      attended to the more highly valued medical interventions and substituted time to 
      care for older patients by socialisation with colleagues. RELEVANCE TO CLINICAL
      PRACTICE: This study draws attention to the discrepancy between stated and
      practice values in the care of hospitalised older patients. Clarification of
      disciplinary values and the professional role is required, including the adoption
      of models of care that refocus nursing care through the promotion of holistic
      practices.
FAU - Milton-Wildey, Kathleen
AU  - Milton-Wildey K
AD  - Undergraduate Nursing, Faculty of Nursing, Midwifery & Health, University of
      Technology, Sydney, Australia. kathleen.milton-wildey@uts.edu.au
FAU - O'Brien, Louise
AU  - O'Brien L
LA  - eng
PT  - Journal Article
DEP - 20100316
PL  - England
TA  - J Clin Nurs
JT  - Journal of clinical nursing
JID - 9207302
MH  - Acute Disease/*nursing
MH  - Aged
MH  - *Decision Making
MH  - Humans
MH  - Nurse-Patient Relations
MH  - *Nursing Staff, Hospital
EDAT- 2010/03/30 06:00
MHDA- 2010/08/25 06:00
CRDT- 2010/03/30 06:00
PHST- 2010/03/30 06:00 [entrez]
PHST- 2010/03/30 06:00 [pubmed]
PHST- 2010/08/25 06:00 [medline]
AID - JCN3141 [pii]
AID - 10.1111/j.1365-2702.2009.03141.x [doi]
PST - ppublish
SO  - J Clin Nurs. 2010 May;19(9-10):1252-60. doi: 10.1111/j.1365-2702.2009.03141.x.
      Epub 2010 Mar 16.


PMID- 20345695
OWN - NLM
STAT- MEDLINE
DCOM- 20101007
LR  - 20100603
IS  - 1365-2923 (Electronic)
IS  - 0308-0110 (Linking)
VI  - 44
IP  - 5
DP  - 2010 May
TI  - Cultural and hierarchical influences: ethical issues faced by Taiwanese nursing
      students.
PG  - 475-84
LID - 10.1111/j.1365-2923.2009.03589.x [doi]
AB  - OBJECTIVES Improving nurses' competence in resolving clinical ethical issues must
      start with ethics education in training and clinical practice. However, many
      students complain that they cannot apply classroom learning to actual clinical
      scenarios. This study explored ethical issues and dilemmas, and their impact
      experienced by student nurses in clinical practice. METHODS Focus groups were
      conducted with 44 first-year student nurses from a 2-year college course in
      northern Taiwan. Interviews were tape-recorded and verbatim transcripts were
      analysed using content analysis. RESULTS Students expressed and discussed their
      views in eight focus groups. Analysis of interviews revealed five themes:
      frustration at inability to help some patients; oppression caused by lower
      status; lack of honesty and ethical courage; powerlessness, and
      self-encouragement in adversity. CONCLUSIONS Taiwanese nurse ethics training was 
      only recently introduced and the curriculum has not addressed the clinical
      reality in Taiwan. This reality includes limitations arising from the medical
      hierarchy and the socio-cultural role of families in medical decision making,
      which may inhibit ethical judgements and decision making. In clinical dilemmas,
      the most common problems faced by Taiwanese nursing students involved not knowing
      how to handle some situations, inability to abide by principles, and a lack of
      appropriate role models. Hence, we suggest that nursing ethics education should: 
      (i) integrate scenarios involving ethical dilemmas into daily routines; (ii) give
      students opportunities to discuss their feelings about their experiences; (iii)
      allow teachers and students to talk about scenarios with ethical implications,
      and (iv) provide students with opportunities to reflect on clinical scenarios in 
      order to clarify their values and learn how to respect the value of life.
FAU - Yeh, Mei-Yu
AU  - Yeh MY
AD  - Department of Nursing, Chang Gung Institute of Technology, Kwei-Shan Hsiang,
      Tao-Yuan, Taiwan.
FAU - Wu, Shu-Mei
AU  - Wu SM
FAU - Che, Hui-Lian
AU  - Che HL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100319
PL  - England
TA  - Med Educ
JT  - Medical education
JID - 7605655
SB  - IM
CIN - Med Educ. 2010 May;44(5):433-5. PMID: 20518981
MH  - Adult
MH  - Attitude of Health Personnel
MH  - *Culture
MH  - Education, Nursing/methods
MH  - *Ethics, Nursing
MH  - Female
MH  - *Hierarchy, Social
MH  - Humans
MH  - Interviews as Topic
MH  - Nursing Care/*ethics
MH  - Patient Care/*ethics
MH  - Social Dominance
MH  - Students, Nursing/*psychology
MH  - Taiwan
MH  - Young Adult
EDAT- 2010/03/30 06:00
MHDA- 2010/10/12 06:00
CRDT- 2010/03/30 06:00
PHST- 2010/03/30 06:00 [entrez]
PHST- 2010/03/30 06:00 [pubmed]
PHST- 2010/10/12 06:00 [medline]
AID - MED3589 [pii]
AID - 10.1111/j.1365-2923.2009.03589.x [doi]
PST - ppublish
SO  - Med Educ. 2010 May;44(5):475-84. doi: 10.1111/j.1365-2923.2009.03589.x. Epub 2010
      Mar 19.


PMID- 20345513
OWN - NLM
STAT- MEDLINE
DCOM- 20101122
LR  - 20100719
IS  - 1423-0410 (Electronic)
IS  - 0042-9007 (Linking)
VI  - 99
IP  - 2
DP  - 2010 Aug 1
TI  - Phase I/II safety study of transfusion of prion-filtered red cell concentrates in
      transfusion-dependent patients.
PG  - 174-6
LID - 10.1111/j.1423-0410.2010.01330.x [doi]
AB  - BACKGROUND AND OBJECTIVES: Variant Creutzfeldt-Jakob (vCJD) is a fatal
      transfusion transmissible prion infection. No test for vCJD in the donor
      population is currently available. Therefore, prion removal by filtration of red 
      cell concentrate (RCC) is an attractive option for prevention. MATERIALS AND
      METHODS: Twenty patients were recruited with ethical permission, to receive
      clinically necessary transfusion containing one unit of pfRCC. Follow-up at 24
      hours, 6 weeks and 6 months was undertaken. A second pfRCC was administered to 6 
      patients with similar follow up. pfRCC were prepared using the CE marked P-Capt
      device by the IBTS. RESULTS: In 20 transfused patients undergoing one exposure to
      a prion filtered unit, no attributable adverse events were noted. A subset of
      these (n = 6) underwent re-exposure to a further filtered unit without incident. 
      CONCLUSIONS: This phase 1/11 clinical study provides encouraging data on safety
      of prion filtration which can be used to plan more extensive studies on the use
      of filtered blood in adults and children.
FAU - Cahill, M R
AU  - Cahill MR
AD  - Department of Haematology, Cork University Hospital, Cork, Ireland.
      maryr.cahill@hse.ie
FAU - Murphy, T
AU  - Murphy T
FAU - Khan, M
AU  - Khan M
FAU - Fagan, J
AU  - Fagan J
FAU - Murphy, W G
AU  - Murphy WG
LA  - eng
PT  - Clinical Trial, Phase I
PT  - Clinical Trial, Phase II
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100322
PL  - England
TA  - Vox Sang
JT  - Vox sanguinis
JID - 0413606
RN  - 0 (Prions)
SB  - IM
MH  - Adult
MH  - Creutzfeldt-Jakob Syndrome/*blood/prevention & control
MH  - Erythrocyte Transfusion/adverse effects/*methods
MH  - Erythrocytes/*chemistry
MH  - Hemofiltration/methods
MH  - Humans
MH  - Prions/*blood/isolation & purification
EDAT- 2010/03/30 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/03/30 06:00
PHST- 2010/03/30 06:00 [entrez]
PHST- 2010/03/30 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - VOX1330 [pii]
AID - 10.1111/j.1423-0410.2010.01330.x [doi]
PST - ppublish
SO  - Vox Sang. 2010 Aug 1;99(2):174-6. doi: 10.1111/j.1423-0410.2010.01330.x. Epub
      2010 Mar 22.


PMID- 20345507
OWN - NLM
STAT- MEDLINE
DCOM- 20110317
LR  - 20151119
IS  - 1445-5994 (Electronic)
IS  - 1444-0903 (Linking)
VI  - 40
IP  - 5
DP  - 2010 May
TI  - Attitudes of physicians and public to pharmaceutical industry 'gifts'.
PG  - 335-41
LID - 10.1111/j.1445-5994.2010.02233.x [doi]
AB  - BACKGROUND: Few studies have reported the attitudes of both individual doctors
      and members of the public toward the appropriateness of 'gifts' from
      pharmaceutical companies. AIMS: To investigate the attitudes of both doctors and 
      members of the public toward the appropriateness of receiving particular 'gifts' 
      from pharmaceutical companies, and to consider whether public acceptability is a 
      suitable criterion for determining the ethical appropriateness of 'gifts'.
      METHODS: A survey questionnaire of medical specialists in Australia and a survey 
      questionnaire of members of the public itemized 23 'gifts' (valued between AU$10 
      and AU$2500) and asked whether or not each was appropriate. RESULTS: Both medical
      specialists and members of the public believe certain 'gifts' from pharmaceutical
      companies are appropriate but not others. There was a tendency for members of the
      public to be more permissive than medical specialists. CONCLUSION: Although some 
      professional guidelines place importance on the attitudes of the general public
      to 'gift' giving, and other guidelines give importance to a need for transparency
      and public accountability, we question whether public acceptability is a suitable
      criterion for determining the ethical appropriateness of 'gifts'. We suggest that
      more weight be given to the need for independence of clinical decision making,
      with empirical evidence indicating that even small 'gifts' can bias clinicians'
      judgments, and to important values such as the primacy of patient welfare,
      autonomy and social justice. We conclude that it is time to eliminate giving and 
      receiving of promotional items between the pharmaceutical industry and members of
      health professions.
FAU - Macneill, P U
AU  - Macneill PU
AD  - Centre for Values Ethics & the Law in Medicine, University of Sydney, Sydney,
      Australia. medpum@nus.edu.sg
FAU - Kerridge, I H
AU  - Kerridge IH
FAU - Newby, D
AU  - Newby D
FAU - Stokes, B J
AU  - Stokes BJ
FAU - Doran, E
AU  - Doran E
FAU - Henry, D A
AU  - Henry DA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100323
PL  - Australia
TA  - Intern Med J
JT  - Internal medicine journal
JID - 101092952
SB  - IM
CIN - Intern Med J. 2010 May;40(5):321-2. PMID: 20575991
CIN - Intern Med J. 2010 Nov;40(11):799; author reply 799-800. PMID: 21108720
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Drug Industry/*ethics
MH  - Female
MH  - Gift Giving/*ethics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Physicians/*ethics/psychology
MH  - *Public Opinion
MH  - Random Allocation
MH  - Surveys and Questionnaires
EDAT- 2010/03/30 06:00
MHDA- 2011/03/18 06:00
CRDT- 2010/03/30 06:00
PHST- 2010/03/30 06:00 [entrez]
PHST- 2010/03/30 06:00 [pubmed]
PHST- 2011/03/18 06:00 [medline]
AID - IMJ2233 [pii]
AID - 10.1111/j.1445-5994.2010.02233.x [doi]
PST - ppublish
SO  - Intern Med J. 2010 May;40(5):335-41. doi: 10.1111/j.1445-5994.2010.02233.x. Epub 
      2010 Mar 23.


PMID- 20345406
OWN - NLM
STAT- MEDLINE
DCOM- 20120518
LR  - 20120119
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 26
IP  - 2
DP  - 2012 Feb
TI  - Continuing the definition of death debate: the report of the president's council 
      on bioethics on controversies in the determination of death.
PG  - 101-7
LID - 10.1111/j.1467-8519.2010.01812.x [doi]
AB  - The President's Council on Bioethics has recently released a report supportive of
      the continued use of brain death as a criterion for human death. The Council's
      conclusions were based on a conception of life that stressed external work as the
      fundamental marker of organismic life. With respect to human life, it is
      spontaneous respiration in particular that indicates an ability to interact with 
      the external environment, and so indicates the presence of life. Conversely,
      irreversible apnoea marks an inability to carry out the necessary work of life,
      an inability which the Council considers an indicator of death. This conception
      has been conceived to circumvent criticisms of the previous model of loss of
      somatic integration, a model the Council admits that, in the presence of evidence
      of continuing functional integration in brain dead patients, was looking less
      than convincing. Nevertheless, by focusing on external work and ignoring the more
      essential work of integrative unity, the Council's conception of the nature of
      life is untenable, and of no assistance in supporting a relation of equivalence
      between the concepts of brain death and death. Consequently, the Council's
      conclusions do little to advance the definition of death debate, a potentially
      intractable debate that may necessitate the investigation of alternate ethical
      justifications for organ harvesting.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Thomas, Albert Garth
AU  - Thomas AG
AD  - University of Queensland, Australia. th56370@bigpond.net.au
LA  - eng
PT  - Journal Article
DEP - 20100324
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Advisory Committees
MH  - Bioethical Issues
MH  - Brain Death/*diagnosis/legislation & jurisprudence
MH  - Humans
MH  - United States
EDAT- 2010/03/30 06:00
MHDA- 2012/05/19 06:00
CRDT- 2010/03/30 06:00
PHST- 2010/03/30 06:00 [entrez]
PHST- 2010/03/30 06:00 [pubmed]
PHST- 2012/05/19 06:00 [medline]
AID - BIOT1812 [pii]
AID - 10.1111/j.1467-8519.2010.01812.x [doi]
PST - ppublish
SO  - Bioethics. 2012 Feb;26(2):101-7. doi: 10.1111/j.1467-8519.2010.01812.x. Epub 2010
      Mar 24.


PMID- 20345405
OWN - NLM
STAT- MEDLINE
DCOM- 20120423
LR  - 20111215
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 26
IP  - 1
DP  - 2012 Jan
TI  - Risk and mid-level moral principles.
PG  - 8-14
LID - 10.1111/j.1467-8519.2010.01813.x [doi]
AB  - We discuss ethical aspects of risk-taking with special focus on principlism and
      mid-level moral principles. A new distinction between the strength of an
      obligation and the degree to which it is valid is proposed. We then use this
      distinction for arguing that, in cases where mid-level moral principles come into
      conflict, the moral status of the act under consideration may be indeterminate,
      in a sense rendered precise in the paper. We apply this thought to issues related
      to pandemic influenza vaccines. The main conclusion of the paper is that on a
      principlist approach some acts may be neither right nor wrong (or neither
      permissible nor impermissible), and we claim that this has important implications
      for how we ought to make decisions under risk.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Espinoza, Nicolas
AU  - Espinoza N
AD  - Swedish Defence Research Agency, Stockholm, Sweden.
FAU - Peterson, Martin
AU  - Peterson M
LA  - eng
PT  - Journal Article
DEP - 20100324
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Bioethical Issues
MH  - Humans
MH  - *Morals
MH  - *Principle-Based Ethics
MH  - Risk
MH  - *Social Responsibility
EDAT- 2010/03/30 06:00
MHDA- 2012/04/24 06:00
CRDT- 2010/03/30 06:00
PHST- 2010/03/30 06:00 [entrez]
PHST- 2010/03/30 06:00 [pubmed]
PHST- 2012/04/24 06:00 [medline]
AID - BIOT1813 [pii]
AID - 10.1111/j.1467-8519.2010.01813.x [doi]
PST - ppublish
SO  - Bioethics. 2012 Jan;26(1):8-14. doi: 10.1111/j.1467-8519.2010.01813.x. Epub 2010 
      Mar 24.


PMID- 20237217
OWN - NLM
STAT- MEDLINE
DCOM- 20100708
LR  - 20100318
IS  - 1549-490X (Electronic)
IS  - 1083-7159 (Linking)
VI  - 15 Suppl 1
DP  - 2010
TI  - Ethical issues in patient-physician communication about therapy for cancer:
      professional responsibilities of the oncologist.
PG  - 43-8
LID - 10.1634/theoncologist.2010-S1-43 [doi]
AB  - Value in cancer care from a patient-centered perspective not only requires full
      oncologist-to-patient communication of information about potential treatments,
      but also imbues in the oncologist a responsibility to evaluate the value of
      cancer therapies and to offer to patients only those potential therapies that are
      appropriate for the patient. A case is presented in which the possibility of a
      low-probability treatment presented without adequate context or advice led to a
      prolonged, unsatisfying death for a young person with advanced cancer. The
      professional responsibility of the oncologist includes provision of care based on
      wise, cost-effective management aimed at meeting the needs of the individual
      patient. The oncologist has the clinical knowledge, is aware of a patient's
      clinical details, and has the relationship with the patient that permits
      understanding his or her values in order to guide cancer care decisions. The
      oncologist must identify the spectrum of treatments that are indicated for the
      patient, understand patient preferences and goals in order to inform the patient 
      about options, and advise the patient concerning choice of cancer care.
      Oncologists as a professional group can ensure the use of standardized outcome
      measures, promote communication of prognosis and goals in order to guide optimal 
      cancer care choices, and ensure appropriate patient selection and reasonableness 
      in the cost per benefit increment of treatments. In this way, oncologists can
      ensure value in cancer care.
FAU - Wenger, Neil S
AU  - Wenger NS
AD  - Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles,
      California, USA. nwenger@mednet.ucla.edu
FAU - Vespa, Paul M
AU  - Vespa PM
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Oncologist
JT  - The oncologist
JID - 9607837
SB  - IM
MH  - Adult
MH  - Brain Neoplasms/diagnosis/secondary/therapy
MH  - Carcinoma, Non-Small-Cell Lung/secondary/therapy
MH  - *Communication
MH  - Delivery of Health Care/*standards
MH  - *Ethics, Medical
MH  - Fatal Outcome
MH  - Female
MH  - Glioblastoma/diagnosis/therapy
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Lung Neoplasms/pathology/therapy
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/*diagnosis/psychology/*therapy
MH  - Palliative Care
MH  - *Physician's Role
MH  - Physician-Patient Relations/ethics
EDAT- 2010/03/30 06:00
MHDA- 2010/07/09 06:00
CRDT- 2010/03/19 06:00
PHST- 2010/03/19 06:00 [entrez]
PHST- 2010/03/30 06:00 [pubmed]
PHST- 2010/07/09 06:00 [medline]
AID - 15/suppl_1/43 [pii]
AID - 10.1634/theoncologist.2010-S1-43 [doi]
PST - ppublish
SO  - Oncologist. 2010;15 Suppl 1:43-8. doi: 10.1634/theoncologist.2010-S1-43.


PMID- 20237216
OWN - NLM
STAT- MEDLINE
DCOM- 20100708
LR  - 20100318
IS  - 1549-490X (Electronic)
IS  - 1083-7159 (Linking)
VI  - 15 Suppl 1
DP  - 2010
TI  - Ethical and value issues in insurance coverage for cancer treatment.
PG  - 36-42
LID - 10.1634/theoncologist.2010-S1-36 [doi]
AB  - Many new cancer drugs provide only limited benefits, but at very great cost, for 
      example, $200,000-$300,000 per quality-adjusted life year produced. By most
      standards of value or cost-effectiveness, this does not represent good value. I
      first review several of the causes of this value failure, including monopoly
      patents, prohibitions on Medicare's negotiating on drug prices, health insurance 
      protecting patients from costs, and financial incentives of physicians to use
      these drugs. Besides value or cost-effectiveness, the other principal aim in
      health care resource allocation should be equity among the population served. I
      examine several equity considerations-priority to the worse off, aggregation and 
      special priority to life extension, and the rule of rescue-and argue that none
      justifies greater priority for cancer treatment on the grounds of equity.
      Finally, I conclude by noting two recent policy changes that are in the wrong
      direction for achieving value in cancer care, and suggesting some small steps
      that could take us in the right direction.
FAU - Brock, Dan W
AU  - Brock DW
AD  - Harvard Medical School, Boston, Massachusetts 02115, USA.
      dan_brock@hms.harvard.edu
LA  - eng
PT  - Journal Article
PL  - England
TA  - Oncologist
JT  - The oncologist
JID - 9607837
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Antineoplastic Agents/*economics
MH  - Cost-Benefit Analysis
MH  - *Drug Costs
MH  - Ethics, Medical
MH  - Health Care Costs/*ethics
MH  - Humans
MH  - Insurance Coverage/economics/*ethics
MH  - Insurance, Health/economics/*ethics
MH  - Massachusetts
MH  - Neoplasms/drug therapy/*economics
MH  - Quality-Adjusted Life Years
EDAT- 2010/03/30 06:00
MHDA- 2010/07/09 06:00
CRDT- 2010/03/19 06:00
PHST- 2010/03/19 06:00 [entrez]
PHST- 2010/03/30 06:00 [pubmed]
PHST- 2010/07/09 06:00 [medline]
AID - 15/suppl_1/36 [pii]
AID - 10.1634/theoncologist.2010-S1-36 [doi]
PST - ppublish
SO  - Oncologist. 2010;15 Suppl 1:36-42. doi: 10.1634/theoncologist.2010-S1-36.


PMID- 20339930
OWN - NLM
STAT- MEDLINE
DCOM- 20101220
LR  - 20220409
IS  - 1572-8633 (Electronic)
IS  - 1386-7423 (Linking)
VI  - 13
IP  - 3
DP  - 2010 Aug
TI  - Realizing autonomy in responsive relationships.
PG  - 215-23
LID - 10.1007/s11019-010-9241-8 [doi]
AB  - The goal of this article is to augment the ethical discussion among nurses with
      the findings from empirical research on autonomy of older adults with type 2
      diabetes mellitus. There are many factors influencing autonomy. These include:
      health conditions, treatment, knowledge, experience and skills, personal approach
      as well as familial patterns, type of relationship, life history and social
      context. Fifteen older adults with type 2 diabetes mellitus were interviewed in a
      nurse-led diabetes clinic. These participants perceive three processes which
      support autonomy in responsive relationships: preserving patterns of concern and 
      interaction, nurturing collaborative responsibilities and being closely engaged
      in trustful and helpful family relations. People with diabetes realize autonomy
      in various responsive relationships in their unique life context. Next, we
      performed a literature review of care ethics and caring in nursing with regard to
      relational autonomy. We classified the literature in five strands of care:
      attitude-oriented, dialogue-oriented, activity-oriented, relationship-oriented
      and life-oriented. According to our respondents, autonomy in responsive
      relationships is fostered when patient, nurses, professionals of the health team 
      and family members carry out care activities supported by a relational attitude
      of care. They can best realize autonomy in relationships with others when several
      essential aspects of care and caring are present in their lives. Therefore, we
      advocate a comprehensive approach to care and caring.
FAU - Moser, Albine
AU  - Moser A
AD  - Department of General Practice, Faculty of Health, Medicine and Life Science,
      Care and Public Health Research Institute, Maastricht University, P.O. Box 616,
      6200 MD, Maastricht, The Netherlands. albine.moser@hag.unimaas.nl
FAU - Houtepen, Rob
AU  - Houtepen R
FAU - Spreeuwenberg, Cor
AU  - Spreeuwenberg C
FAU - Widdershoven, Guy
AU  - Widdershoven G
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Med Health Care Philos
JT  - Medicine, health care, and philosophy
JID - 9815900
SB  - IM
MH  - Aged
MH  - Diabetes Mellitus, Type 2/nursing/*psychology
MH  - *Family Relations
MH  - Humans
MH  - Netherlands
MH  - *Nurse-Patient Relations
MH  - Nursing Research
MH  - *Personal Autonomy
MH  - Social Support
PMC - PMC2920412
EDAT- 2010/03/27 06:00
MHDA- 2010/12/21 06:00
CRDT- 2010/03/27 06:00
PHST- 2010/03/27 06:00 [entrez]
PHST- 2010/03/27 06:00 [pubmed]
PHST- 2010/12/21 06:00 [medline]
AID - 10.1007/s11019-010-9241-8 [doi]
PST - ppublish
SO  - Med Health Care Philos. 2010 Aug;13(3):215-23. doi: 10.1007/s11019-010-9241-8.


PMID- 20339830
OWN - NLM
STAT- MEDLINE
DCOM- 20101006
LR  - 20220310
IS  - 1432-1440 (Electronic)
IS  - 0946-2716 (Linking)
VI  - 88
IP  - 7
DP  - 2010 Jul
TI  - Transgenic pigs as models for translational biomedical research.
PG  - 653-64
LID - 10.1007/s00109-010-0610-9 [doi]
AB  - The translation of novel discoveries from basic research to clinical application 
      is a long, often inefficient, and thus costly process. Accordingly, the process
      of drug development requires optimization both for economic and for ethical
      reasons, in order to provide patients with appropriate treatments in a reasonable
      time frame. Consequently, "Translational Medicine" became a top priority in
      national and international roadmaps of human health research. Appropriate animal 
      models for the evaluation of efficacy and safety of new drugs or therapeutic
      concepts are critical for the success of translational research. In this context 
      rodent models are most widely used. At present, transgenic pigs are increasingly 
      being established as large animal models for selected human diseases. The first
      pig whole genome sequence and many other genomic resources will be available in
      the near future. Importantly, efficient and precise techniques for the genetic
      modification of pigs have been established, facilitating the generation of
      tailored disease models. This article provides an overview of the current
      techniques for genetic modification of pigs and the transgenic pig models
      established for neurodegenerative diseases, cardiovascular diseases, cystic
      fibrosis, and diabetes mellitus.
FAU - Aigner, Bernhard
AU  - Aigner B
AD  - Department of Veterinary Sciences; and Laboratory for Functional Genome Analysis 
      (LAFUGA), Gene Center, LMU Munich, Feodor-Lynen-Str. 25, 81377 Munich, Germany.
      b.aigner@gen.vetmed.uni-muenchen.de
FAU - Renner, Simone
AU  - Renner S
FAU - Kessler, Barbara
AU  - Kessler B
FAU - Klymiuk, Nikolai
AU  - Klymiuk N
FAU - Kurome, Mayuko
AU  - Kurome M
FAU - Wunsch, Annegret
AU  - Wunsch A
FAU - Wolf, Eckhard
AU  - Wolf E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100326
PL  - Germany
TA  - J Mol Med (Berl)
JT  - Journal of molecular medicine (Berlin, Germany)
JID - 9504370
RN  - 0 (Biomarkers)
SB  - IM
MH  - Animals
MH  - *Animals, Genetically Modified
MH  - Biomarkers/metabolism
MH  - *Biomedical Research
MH  - *Disease
MH  - Disease Models, Animal
MH  - Genetic Engineering/methods
MH  - Humans
MH  - *Swine
MH  - *Translational Research, Biomedical
RF  - 72
EDAT- 2010/03/27 06:00
MHDA- 2010/10/07 06:00
CRDT- 2010/03/27 06:00
PHST- 2009/09/01 00:00 [received]
PHST- 2010/03/02 00:00 [accepted]
PHST- 2010/02/26 00:00 [revised]
PHST- 2010/03/27 06:00 [entrez]
PHST- 2010/03/27 06:00 [pubmed]
PHST- 2010/10/07 06:00 [medline]
AID - 10.1007/s00109-010-0610-9 [doi]
PST - ppublish
SO  - J Mol Med (Berl). 2010 Jul;88(7):653-64. doi: 10.1007/s00109-010-0610-9. Epub
      2010 Mar 26.


PMID- 20339795
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20190917
IS  - 0104-4230 (Print)
IS  - 0104-4230 (Linking)
VI  - 56
IP  - 1
DP  - 2010 Jan-Feb
TI  - [Fundamental aspects on animal research as applied to experimental surgery].
PG  - 103-11
LID - S0104-42302010000100024 [pii]
AB  - This study aimed to present the general principles for experiments performed on
      laboratory animals as required by international and national ethical committees
      on animal welfare. Compliance to these principles is a prerequisite for
      publication in international journals. Details of genetic, sanitary and
      environmental standards, transportation, acclimation, environmental enrichment,
      appropriate education and training of all those involved in handling of live
      animals, information management strategy, biossecurity, diet, anesthesia,
      analgesia, postoperative care and euthanasia for Mus musculus (mice), Rattus
      norvegicus (rat), Oryctolagus cuniculus (rabbit) and Sus scropha domesticus (pig)
      combined with well planned biomedical research are fundamental to increase the
      accuracy, reproducibility and precision of the experimental results.
FAU - Damy, Sueli Blanes
AU  - Damy SB
AD  - Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP. damy@usp.br
FAU - Camargo, Roberto Souza
AU  - Camargo RS
FAU - Chammas, Rober
AU  - Chammas R
FAU - Figueiredo, Luiz Francisco Poli de
AU  - Figueiredo LF
LA  - por
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Aspectos fundamentais da experimentacao animal - aplicacoes em cirurgia
      experimental.
PL  - Brazil
TA  - Rev Assoc Med Bras (1992)
JT  - Revista da Associacao Medica Brasileira (1992)
JID - 9308586
SB  - IM
MH  - Animal Experimentation/*ethics/standards
MH  - Animals
MH  - Animals, Laboratory
MH  - Bioethical Issues
MH  - Mice
MH  - Rabbits
MH  - Rats
MH  - Surgical Procedures, Operative/*ethics/standards
MH  - Sus scrofa
EDAT- 2010/03/27 06:00
MHDA- 2011/10/01 06:00
CRDT- 2010/03/27 06:00
PHST- 2008/06/30 00:00 [received]
PHST- 2009/09/19 00:00 [accepted]
PHST- 2010/03/27 06:00 [entrez]
PHST- 2010/03/27 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - S0104-42302010000100024 [pii]
AID - 10.1590/s0104-42302010000100024 [doi]
PST - ppublish
SO  - Rev Assoc Med Bras (1992). 2010 Jan-Feb;56(1):103-11. doi:
      10.1590/s0104-42302010000100024.


PMID- 20339786
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20190917
IS  - 0104-4230 (Print)
IS  - 0104-4230 (Linking)
VI  - 56
IP  - 1
DP  - 2010 Jan-Feb
TI  - [Equity in the health system according to Brazilian bioethicists].
PG  - 47-50
LID - S0104-42302010000100015 [pii]
AB  - OBJECTIVE: To understand the meaning assigned to ethical thought that should
      guide Brazilian bioethicists regarding the equity of a Health System. METHODS:
      Between July 2007 and July 2008, 20 bioethicists, directors and former directors 
      of the 'Sociedade Brasileira de Bioetica' (Bioethics Brazilian Society) and their
      regional administrations were interviewed. RESULTS: Discourse analysis led to
      definition of these main points: To treat the unequals unequally according to
      their needs; Compensate equity and inequalities; Distributive justice and
      maximization of benefits; Justice and social merit and Justice and rights.
      CONCLUSION: Research results disclose a pluralism of values that jeopardizes
      determination of moral equity in the health system., Exhausting dialogues among
      all interested parties are necessary to reach a possible consensus.
FAU - Fortes, Paulo Antonio de Carvalho
AU  - Fortes PA
AD  - Faculdade de Saude Publica, Universidade de Sao Paulo, S.Paulo, SP.
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - A equidade no sistema de saude na visao de bioeticistas brasileiros.
PL  - Brazil
TA  - Rev Assoc Med Bras (1992)
JT  - Revista da Associacao Medica Brasileira (1992)
JID - 9308586
SB  - IM
MH  - Brazil
MH  - *Ethicists
MH  - Health Policy
MH  - Health Services Accessibility/*ethics
MH  - Humans
MH  - National Health Programs/*ethics
MH  - Social Justice/ethics
EDAT- 2010/03/27 06:00
MHDA- 2011/10/01 06:00
CRDT- 2010/03/27 06:00
PHST- 2009/04/27 00:00 [received]
PHST- 2009/09/19 00:00 [accepted]
PHST- 2010/03/27 06:00 [entrez]
PHST- 2010/03/27 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - S0104-42302010000100015 [pii]
AID - 10.1590/s0104-42302010000100015 [doi]
PST - ppublish
SO  - Rev Assoc Med Bras (1992). 2010 Jan-Feb;56(1):47-50. doi:
      10.1590/s0104-42302010000100015.


PMID- 20339779
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20220316
IS  - 0104-4230 (Print)
IS  - 0104-4230 (Linking)
VI  - 56
IP  - 1
DP  - 2010 Jan-Feb
TI  - [Bioethical analysis of the use of newly dead patients in medical learning].
PG  - 11-6
LID - S0104-42302010000100008 [pii]
AB  - OBJECTIVE: The purpose of this article is to carry out, a discussion on the
      subject of bioethics and cadavers based upon a critic review of literature.
      METHODS: A review of literature, was made with a survey of articles between 1977 
      and 2007 in the sites 'Biblioteca Virtual de Saude', PubMed and SciElo, utilizing
      the keywords: newly deceased patients, newly dead patients, simulators,. This was
      complemented by a critical evaluation of books published in the area of ethics
      and bioethics. RESULTS: The possibility to develop learning without orientation
      by a supervisor is doubtful.. The utilization of newly dead for learning invasive
      procedures is very frequent and seldom admitted. These procedures, are usually,
      carried out secretly, without the knowledge and consent of the family. The
      ethical aspects of these practices are not discussed in the practical medical
      education. CONCLUSION: It essential that the ethics of use of recent deceased
      become a necessary content of graduate education. Performance of these procedures
      by students should always be authorized by family members. The simulators meet
      the requirements of training. Discussions about the ethical and bioethical
      aspects cannot be separated from practical considerations during the students
      learning time.
FAU - Gomes, Andreia Patricia
AU  - Gomes AP
AD  - Escola Nacional de Saude Publica Sergio Arouca ( ENSP) -Fundacao Oswaldo Cruz -
      Fiocruz, Rio de Janeiro, RJ.
FAU - Rego, Sergio
AU  - Rego S
FAU - Palacios, Marisa
AU  - Palacios M
FAU - Siqueira-Batista, Rodrigo
AU  - Siqueira-Batista R
LA  - por
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Analise bioetica do uso de recem-cadaveres na aprendizagem pratica em medicina.
PL  - Brazil
TA  - Rev Assoc Med Bras (1992)
JT  - Revista da Associacao Medica Brasileira (1992)
JID - 9308586
SB  - IM
MH  - Attitude to Death
MH  - *Bioethical Issues
MH  - *Cadaver
MH  - Dissection/education/ethics
MH  - Education, Medical/*ethics
MH  - Humans
MH  - *Students, Medical
MH  - Teaching/*ethics/methods
EDAT- 2010/03/27 06:00
MHDA- 2011/10/01 06:00
CRDT- 2010/03/27 06:00
PHST- 2008/11/09 00:00 [received]
PHST- 2009/08/18 00:00 [accepted]
PHST- 2010/03/27 06:00 [entrez]
PHST- 2010/03/27 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - S0104-42302010000100008 [pii]
AID - 10.1590/s0104-42302010000100008 [doi]
PST - ppublish
SO  - Rev Assoc Med Bras (1992). 2010 Jan-Feb;56(1):11-6. doi:
      10.1590/s0104-42302010000100008.


PMID- 20339771
OWN - NLM
STAT- MEDLINE
DCOM- 20100816
LR  - 20190911
IS  - 0034-7167 (Print)
IS  - 0034-7167 (Linking)
VI  - 63
IP  - 1
DP  - 2010 Jan-Feb
TI  - [Research ethics committees: challenges in the submission and evaluation of
      scientific projects].
PG  - 145-7
LID - S0034-71672010000100025 [pii]
AB  - This article aimed at reflecting and discussing about some difficulties in the
      submission and evaluation of scientific projects to the Research Ethics
      Committee, from an experience in post-graduation. Among these difficulties, there
      was a need for submission of a single project to several CEP as demand for part
      of the health facilities involved, which showed discrepancies with regard to the 
      matter. Another issue, involving the reports, which are still based on biomedical
      models, which hinder the evaluation of research projects in nursing and other
      sciences. However, one of the great challenges of CEP is to ensure that
      researches with human beings are carried out within an ethics framework, without 
      be an obstacle to their development.
FAU - Furukawa, Patricia de Oliveira
AU  - Furukawa Pde O
AD  - Departamento de Enfermagem, Universidade Federal de Sao Paulo, Sao Paulo, SP.
      patricia.furukawa@unifesp.br
FAU - Cunha, Isabel Cristina Kowal Olm
AU  - Cunha IC
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Comites de etica em pesquisa: desafios na submissao e avaliacao de projetos
      cientificos.
PL  - Brazil
TA  - Rev Bras Enferm
JT  - Revista brasileira de enfermagem
JID - 7910105
MH  - *Ethics Committees, Research
MH  - Nursing Research/*standards
EDAT- 2010/03/27 06:00
MHDA- 2010/08/17 06:00
CRDT- 2010/03/27 06:00
PHST- 2008/09/17 00:00 [received]
PHST- 2010/01/06 00:00 [accepted]
PHST- 2010/03/27 06:00 [entrez]
PHST- 2010/03/27 06:00 [pubmed]
PHST- 2010/08/17 06:00 [medline]
AID - S0034-71672010000100025 [pii]
AID - 10.1590/s0034-71672010000100025 [doi]
PST - ppublish
SO  - Rev Bras Enferm. 2010 Jan-Feb;63(1):145-7. doi: 10.1590/s0034-71672010000100025.


PMID- 20339749
OWN - NLM
STAT- MEDLINE
DCOM- 20100816
LR  - 20190911
IS  - 0034-7167 (Print)
IS  - 0034-7167 (Linking)
VI  - 63
IP  - 1
DP  - 2010 Jan-Feb
TI  - [Quality of life of the colostomized person with or without use of methods of
      bowel control].
PG  - 16-21
LID - S0034-71672010000100003 [pii]
AB  - OBJECTIVE: To evaluate and to compare the quality of life (QoL) of colostomy
      people, using or not using the bowel control methods (BCM), in other words, the
      colostomy irrigation and the plug system, considering the hypothesis that people 
      who used them had better QoL. METHOD: This study was carried out in the
      Heliopolis Hospital Outpatient Department, after the project approval for the
      Ethical and Research Committee, using the WHOQoL-bref. The sample was constituted
      of two groups: 50 colostomy people with BCM and 50, without BCM. RESULTS: The
      Group with BCM had a QoL significantly higher, being this observed in all the
      Domains and in the Overall QoL, than those of the Group without BCM. CONCLUSION: 
      The study confirmed the hypothesis that the QoL of the Group with BCM is better
      than the Group without BCM.
FAU - Cesaretti, Isabel Umbelina Ribeiro
AU  - Cesaretti IU
AD  - Departamento de Enfermagem, Universidade Federal de Sao Paulo, Sao Paulo, SP.
FAU - Santos, Vera Lucia Conceicao Gouveia
AU  - Santos VL
FAU - Vianna, Lucila Amaral Carneiro
AU  - Vianna LA
LA  - por
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
TT  - Qualidade de vida de pessoas colostomizadas com e sem uso de metodos de controle 
      intestinal.
PL  - Brazil
TA  - Rev Bras Enferm
JT  - Revista brasileira de enfermagem
JID - 7910105
MH  - Colostomy/*methods
MH  - Cross-Sectional Studies
MH  - Humans
MH  - *Quality of Life
EDAT- 2010/03/27 06:00
MHDA- 2010/08/17 06:00
CRDT- 2010/03/27 06:00
PHST- 2008/09/01 00:00 [received]
PHST- 2009/12/12 00:00 [accepted]
PHST- 2010/03/27 06:00 [entrez]
PHST- 2010/03/27 06:00 [pubmed]
PHST- 2010/08/17 06:00 [medline]
AID - S0034-71672010000100003 [pii]
AID - 10.1590/s0034-71672010000100003 [doi]
PST - ppublish
SO  - Rev Bras Enferm. 2010 Jan-Feb;63(1):16-21. doi: 10.1590/s0034-71672010000100003.


PMID- 20339727
OWN - NLM
STAT- MEDLINE
DCOM- 20110124
LR  - 20191027
IS  - 1516-4446 (Print)
IS  - 1516-4446 (Linking)
VI  - 32
IP  - 1
DP  - 2010 Mar
TI  - [Ethics and publication of single case reports].
PG  - 2-3
LID - S1516-44462010000100002 [pii]
FAU - Goldim, Jose Roberto
AU  - Goldim JR
FAU - Fleck, Marcelo P
AU  - Fleck MP
LA  - por
PT  - Editorial
TT  - Etica e publicacao de relatos de caso individuais.
PL  - Brazil
TA  - Braz J Psychiatry
JT  - Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
JID - 100895975
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Health Records, Personal/*ethics
MH  - Humans
MH  - Informed Consent/ethics
MH  - Privacy
MH  - Publishing/*ethics
MH  - Research Design
EDAT- 2010/03/27 06:00
MHDA- 2011/01/25 06:00
CRDT- 2010/03/27 06:00
PHST- 2010/03/27 06:00 [entrez]
PHST- 2010/03/27 06:00 [pubmed]
PHST- 2011/01/25 06:00 [medline]
AID - S1516-44462010000100002 [pii]
AID - 10.1590/s1516-44462010000100002 [doi]
PST - ppublish
SO  - Braz J Psychiatry. 2010 Mar;32(1):2-3. doi: 10.1590/s1516-44462010000100002.


PMID- 20339285
OWN - NLM
STAT- MEDLINE
DCOM- 20110419
LR  - 20211020
IS  - 1662-8063 (Electronic)
IS  - 1662-4246 (Linking)
VI  - 14
IP  - 1
DP  - 2011
TI  - Assessing the privacy risks of data sharing in genomics.
PG  - 17-25
LID - 10.1159/000294150 [doi]
AB  - The protection of identity of participants in medical research has traditionally 
      been guaranteed by the maintenance of the confidentiality of health information
      through mechanisms such as only releasing data in an aggregated form or after
      identifying variables have been removed. This protection of privacy is regarded
      as a fundamental principle of research ethics, through which the support of
      research participants and the public is maintained. Whilst this traditional model
      was adopted for genetics and genomics research, and was generally considered
      broadly fit for purpose, we argue that this approach is increasingly untenable in
      genomics. Privacy risk assessments need to have regard to the whole data
      environment, not merely the quality of the dataset to be released in isolation.
      As sources of data proliferate, issues of privacy protection are increasingly
      problematic in relation to the release of genomic data. However, we conclude
      that, by paying careful attention to potential pitfalls, scientific funders and
      researchers can take an important part in attempts to safeguard the public and
      ensure the continuation of potentially important scientific research.
CI  - Copyright (c) 2010 S. Karger AG, Basel.
FAU - Heeney, C
AU  - Heeney C
AD  - The Ethox Centre, Department of Public Health and Primary Care, University of
      Oxford, Oxford, UK. catherine.heeney@ethox.ox.ac.uk
FAU - Hawkins, N
AU  - Hawkins N
FAU - de Vries, J
AU  - de Vries J
FAU - Boddington, P
AU  - Boddington P
FAU - Kaye, J
AU  - Kaye J
LA  - eng
GR  - WT 083326/Z/07/Z/WT_/Wellcome Trust/United Kingdom
GR  - WT 077869/Z/05/Z/WT_/Wellcome Trust/United Kingdom
GR  - 096599/WT_/Wellcome Trust/United Kingdom
GR  - wt 081407/Z/06/Z/WT_/Wellcome Trust/United Kingdom
GR  - WT 076070/Z/04/Z/WT_/Wellcome Trust/United Kingdom
GR  - WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100329
PL  - Switzerland
TA  - Public Health Genomics
JT  - Public health genomics
JID - 101474167
SB  - IM
MH  - Confidentiality/*ethics
MH  - *Genetic Predisposition to Disease
MH  - Genetic Privacy/*legislation & jurisprudence
MH  - Genetic Research/*ethics
MH  - Genetic Testing/*ethics
MH  - Genomics/*ethics
MH  - Humans
MH  - Risk Assessment
PMC - PMC2872768
EDAT- 2010/03/27 06:00
MHDA- 2011/04/20 06:00
CRDT- 2010/03/27 06:00
PHST- 2009/06/27 00:00 [received]
PHST- 2009/10/05 00:00 [accepted]
PHST- 2010/03/27 06:00 [entrez]
PHST- 2010/03/27 06:00 [pubmed]
PHST- 2011/04/20 06:00 [medline]
AID - 000294150 [pii]
AID - 10.1159/000294150 [doi]
PST - ppublish
SO  - Public Health Genomics. 2011;14(1):17-25. doi: 10.1159/000294150. Epub 2010 Mar
      29.


PMID- 20338963
OWN - NLM
STAT- MEDLINE
DCOM- 20100812
LR  - 20211020
IS  - 1555-905X (Electronic)
IS  - 1555-9041 (Linking)
VI  - 5
IP  - 5
DP  - 2010 May
TI  - Modeling the 4D Study: statins and cardiovascular outcomes in long-term
      hemodialysis patients with diabetes.
PG  - 856-66
LID - 10.2215/CJN.07161009 [doi]
AB  - BACKGROUND AND OBJECTIVES: Randomized, controlled trials (RCTs) are the gold
      standard for defining causal inferences but are sometimes not feasible because of
      cost, ethical, or time considerations. We explored the accuracy and potential use
      of a "simulated trial" through the modeling of a previously published RCT, Die
      Deutsche Diabetes Dialyse Studie (4D Study), a landmark study that investigated
      the cardiovascular benefit of atorvastatin use in 1255 patients with ESRD.
      DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Using a large historical database 
      of interventions and outcomes in dialysis patients, we conducted an observational
      model of the 4D Study in dialysis patients who had type 2 diabetes and were
      prescribed a statin (5144 patients) and matched to a non-statin user (5144
      control subjects) before multivariate modeling. Inclusion, exclusion, and outcome
      parameters of the study, as prespecified by the 4D Study, were strictly modeled
      in this analysis. RESULTS: In covariate- and propensity-adjusted Cox regression, 
      statin use (versus nonuse) was associated with a decrease in the composite
      primary outcome of cardiac death, nonfatal myocardial infarction, and stroke.
      Statin use was also associated with a decrease in cardiovascular mortality and
      all cardiac events combined. The hazard ratios in this observational model were
      numerically comparable to the hazard ratios reported in the 4D Study; however,
      because of the larger number of patients "enrolled," results in this simulated
      study achieved statistical significance. CONCLUSIONS: Statin use was associated
      with some cardiovascular benefit in a simulated trial of patients with ESRD;
      however, the size of benefit was considerably smaller than that seen in the
      general population. Such simulated trials may represent an exploratory,
      cost-effective option when RCTs are not immediately feasible.
FAU - Chan, Kevin E
AU  - Chan KE
AD  - Fresenius Medical Care North America, Waltham, Massachusetts, USA.
      kevin.chan@fmc-na.com
FAU - Thadhani, Ravi
AU  - Thadhani R
FAU - Lazarus, J Michael
AU  - Lazarus JM
FAU - Hakim, Raymond M
AU  - Hakim RM
LA  - eng
PT  - Journal Article
DEP - 20100325
PL  - United States
TA  - Clin J Am Soc Nephrol
JT  - Clinical journal of the American Society of Nephrology : CJASN
JID - 101271570
RN  - 0 (Heptanoic Acids)
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
RN  - 0 (Pyrroles)
RN  - A0JWA85V8F (Atorvastatin)
SB  - IM
CIN - Clin J Am Soc Nephrol. 2010 May;5(5):750-2. PMID: 20360306
MH  - Atorvastatin
MH  - Cardiovascular Diseases/etiology/mortality/*prevention & control
MH  - *Computer Simulation
MH  - Databases as Topic
MH  - Diabetes Mellitus, Type 2/*complications/mortality
MH  - Female
MH  - Heptanoic Acids/*therapeutic use
MH  - Humans
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic use
MH  - Kidney Failure, Chronic/complications/mortality/*therapy
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/etiology/prevention & control
MH  - Proportional Hazards Models
MH  - Pyrroles/*therapeutic use
MH  - *Randomized Controlled Trials as Topic
MH  - *Renal Dialysis/adverse effects
MH  - Risk Assessment
MH  - Risk Factors
MH  - Stroke/etiology/prevention & control
MH  - Time Factors
MH  - Treatment Outcome
MH  - United States
PMC - PMC2863967
EDAT- 2010/03/27 06:00
MHDA- 2010/08/13 06:00
CRDT- 2010/03/27 06:00
PHST- 2010/03/27 06:00 [entrez]
PHST- 2010/03/27 06:00 [pubmed]
PHST- 2010/08/13 06:00 [medline]
AID - CJN.07161009 [pii]
AID - 10.2215/CJN.07161009 [doi]
PST - ppublish
SO  - Clin J Am Soc Nephrol. 2010 May;5(5):856-66. doi: 10.2215/CJN.07161009. Epub 2010
      Mar 25.


PMID- 20338939
OWN - NLM
STAT- MEDLINE
DCOM- 20111020
LR  - 20220408
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 4
DP  - 2010 Apr
TI  - Towards a practical definition of professional behaviour.
PG  - 250-4
LID - 10.1136/jme.2009.035121 [doi]
AB  - CONTEXT: Professionalism remains a challenging part of the medical curriculum to 
      define, teach and evaluate. We suggest that one way to meet these challenges is
      to clarify the definition of professionalism and distinguish this from medical
      ethics. METHODS: Our analysis is two staged. First, we reviewed influential
      definitions of professionalism and separated elements relating to (a)
      ethico-legal competencies, (b) clinical competence and (c) professionalism. In
      reference to professionalism, we then distinguished between aspirational
      virtues/values and specific behaviours. From these, we develop a working
      definition of medical professional behaviour consisting of six domains of
      behaviour: responsibility; relationships with and respect for patients; probity
      and honesty; self awareness and capacity for reflection; collaboration and team
      work; and care of colleagues. Second, we tested this working definition against
      empirical data concerning disciplinary action against practising doctors using
      (a) sources in the literature and (b) an original analysis of complaints received
      by the Medical Board of South Australia. CONCLUSION: Our empirical analysis
      supports the relevance of four of the six potential domains: responsibility;
      relationships with and respect for patients; probity and honesty; self awareness 
      and capacity for reflection. There are additional reasons for retaining
      'collaboration and team work' in the medical professional behaviour curriculum
      but 'care of colleagues' may be better addressed in the ethico-legal curriculum. 
      Our definition of professional behaviour is consistent with the theoretical
      literature, captures behaviours that predict future complaints against
      practitioners and is consistent with current complaints about professionalism in 
      South Australian practitioners. This definition can further the teaching and
      assessing of professional behaviour in medical schools.
FAU - Rogers, Wendy
AU  - Rogers W
AD  - Department of Philosophy, Macquarie University, Sydney, Australia.
FAU - Ballantyne, Angela
AU  - Ballantyne A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Attitude of Health Personnel
MH  - *Ethics, Medical
MH  - Humans
MH  - Professional Competence/*standards
MH  - Professional Misconduct/*psychology
MH  - South Australia
EDAT- 2010/03/27 06:00
MHDA- 2011/10/21 06:00
CRDT- 2010/03/27 06:00
PHST- 2010/03/27 06:00 [entrez]
PHST- 2010/03/27 06:00 [pubmed]
PHST- 2011/10/21 06:00 [medline]
AID - 36/4/250 [pii]
AID - 10.1136/jme.2009.035121 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Apr;36(4):250-4. doi: 10.1136/jme.2009.035121.


PMID- 20338938
OWN - NLM
STAT- MEDLINE
DCOM- 20111020
LR  - 20100326
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 4
DP  - 2010 Apr
TI  - Ethics committees for biomedical research in some African emerging countries:
      which establishment for which independence? A comparison with the USA and Canada.
PG  - 243-9
LID - 10.1136/jme.2009.033142 [doi]
AB  - CONTEXT: The conduct of medical research led by Northern countries in developing 
      countries raises ethical questions. The assessment of research protocols has to
      be twofold, with a first reading in the country of origin and a second one in the
      country where the research takes place. This reading should benefit from an
      independent local ethical review of protocols. Consequently, ethics committees
      for medical research are evolving in Africa. OBJECTIVE: To investigate the
      process of establishing ethics committees and their independence. METHOD:
      Descriptive study of 25 African countries and two North American countries. Data 
      were recorded by questionnaire and interviews. Two visits of ethics committee
      meetings were conducted on the ground: over a period of 3 months in Kigali
      (Rwanda) and 2 months in Washington DC (USA). RESULTS: 22 countries participated 
      in this study, 20 from Africa and two from North America. The response rate was
      80%. 75% of local African committees developed into national ethics committees.
      During the last 5 years, these national committees have grown on a structural
      level. The circumstances of creation and the general context of underdevelopment 
      remain the major challenges in Africa. Their independence could not be ensured
      without continuous training and efficient funding mechanisms. Institutional
      ethics committees are well established in USA and in Canada, whereas ethics
      committees in North America are weakened by the institutional affiliation of
      their members. CONCLUSION: The process of establishing ethics committees could
      affect their functioning and compromise their independence in some African
      countries and in North America.
FAU - Rwabihama, Jean-Paul
AU  - Rwabihama JP
AD  - Joffre-Dupuytren Hospital, Assistance Publique-Hopitaux de Paris (AP-HP), 91210
      Draveil, France. jean-paul.rwabihama@jfr.aphp.fr
FAU - Girre, Catherine
AU  - Girre C
FAU - Duguet, Anne-Marie
AU  - Duguet AM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Africa
MH  - Biomedical Research/*ethics
MH  - Canada
MH  - Cross-Cultural Comparison
MH  - Developing Countries
MH  - Ethics Committees, Research/*organization & administration
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - United States
EDAT- 2010/03/27 06:00
MHDA- 2011/10/21 06:00
CRDT- 2010/03/27 06:00
PHST- 2010/03/27 06:00 [entrez]
PHST- 2010/03/27 06:00 [pubmed]
PHST- 2011/10/21 06:00 [medline]
AID - 36/4/243 [pii]
AID - 10.1136/jme.2009.033142 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Apr;36(4):243-9. doi: 10.1136/jme.2009.033142.


PMID- 20338934
OWN - NLM
STAT- MEDLINE
DCOM- 20111020
LR  - 20100326
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 4
DP  - 2010 Apr
TI  - Some principles of Islamic ethics as found in Harrisian philosophy.
PG  - 226-9
LID - 10.1136/jme.2009.034389 [doi]
AB  - John Harris is one of the prominent philosophers and bioethicists of our time. He
      has published tens of books and hundreds of papers throughout his professional
      life. This paper aims to take a 'deep-look' at Harris' works to argue that it is 
      possible to find some principles of Islamic ethics in Harrisian philosophy,
      namely in his major works, as well as in his personal life. This may be
      surprising, or thought of as a 'big' and 'groundless' claim, since John Harris
      has nothing to do with any religion in his intellectual works. The major features
      of Harrisian philosophy could be defined as consequentialism or utilitarianism
      with liberal overtones. Despite some significant and fundamental differences in
      the application of principles (ie, abortion, euthanasia), the similarities
      between the major principles in Harrisian philosophy and Islamic ethics are
      greater at some points than the similarities between Islamic ethics and some
      other religious ethics (ie, Christian, Judaism). In this study I compare
      Harrisian teachings with major Islamic principles on 'Responsibility',
      'Side-effects and Double-effects', 'Equality', 'Vicious choice, guilt and
      innocence', 'Organ transplantation and property rights' and 'Advance directives'.
FAU - Aksoy, Sahin
AU  - Aksoy S
AD  - Harran University, Faculty of Medicine, Department of Medical History and Ethics,
      Dekanlik Binasi, Yenisehir Kampusu 63200 Sanliurfa, Turkey. sahinaksoy@yahoo.com
LA  - eng
PT  - Biography
PT  - Historical Article
PT  - Journal Article
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Bioethics
MH  - Ethical Theory/history
MH  - *Ethics, Medical
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - *Islam
MH  - Personal Autonomy
MH  - Philosophy, Medical/*history
MH  - *Religion and Medicine
MH  - Social Justice
PS  - Harris J
FPS - Harris, John
EDAT- 2010/03/27 06:00
MHDA- 2011/10/21 06:00
CRDT- 2010/03/27 06:00
PHST- 2010/03/27 06:00 [entrez]
PHST- 2010/03/27 06:00 [pubmed]
PHST- 2011/10/21 06:00 [medline]
AID - 36/4/226 [pii]
AID - 10.1136/jme.2009.034389 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Apr;36(4):226-9. doi: 10.1136/jme.2009.034389.


PMID- 20338933
OWN - NLM
STAT- MEDLINE
DCOM- 20111020
LR  - 20100326
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 4
DP  - 2010 Apr
TI  - How factual do we want the facts? Criteria for a critical appraisal of empirical 
      research for use in ethics.
PG  - 222-5
LID - 10.1136/jme.2009.033225 [doi]
AB  - Most contributions to the current debate about the consideration and application 
      of empirical information in ethics scholarship deal with epistemological issues
      such as the role and the meaning of empirical research in ethical reasoning.
      Despite the increased publication of empirical data in ethics literature we still
      lack systematic analyses and conceptual frameworks that would help us to
      understand the rarely discussed methodological and practical problems in
      appraising empirical research. This paper demonstrates the need for critical
      appraisal and its crucial methodological role in the application of empirical
      information in ethical reasoning. Furthermore, it systematically examines the
      criteria and the appropriate appraisal of empirical research and the associated
      challenges by highlighting current problems in empirical ethics literature. These
      problems reveal the following challenges for a critical and responsible
      consideration of empirical information in ethical reasoning: (i) training in the 
      basic skills of locating and communicating empirical data from the relevant
      studies; (ii) training in basic knowledge of how to critically appraise empirical
      (qualitative and quantitative) research and its results; (iii) determination of
      quality standards for empirical ethics research; (iv) adequate reporting of the
      methodology and results of empirical ethics research in scientific journals.
FAU - Strech, Daniel
AU  - Strech D
AD  - Hannover Medical School, Institute for History, Ethics & Philosophy of Medicine, 
      Carl-Neuberg-Str. 1, 30625 Hannover, Germany. strech.daniel@mh-hannover.de
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Decision Making/*ethics
MH  - *Empirical Research
MH  - *Ethics, Clinical
MH  - *Ethics, Medical
MH  - Evidence-Based Medicine/*ethics
MH  - Humans
MH  - Patient Participation/methods
EDAT- 2010/03/27 06:00
MHDA- 2011/10/21 06:00
CRDT- 2010/03/27 06:00
PHST- 2010/03/27 06:00 [entrez]
PHST- 2010/03/27 06:00 [pubmed]
PHST- 2011/10/21 06:00 [medline]
AID - 36/4/222 [pii]
AID - 10.1136/jme.2009.033225 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Apr;36(4):222-5. doi: 10.1136/jme.2009.033225.


PMID- 20338930
OWN - NLM
STAT- MEDLINE
DCOM- 20111020
LR  - 20211203
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 4
DP  - 2010 Apr
TI  - Translational ethics? The theory-practice gap in medical ethics.
PG  - 207-10
LID - 10.1136/jme.2009.029785 [doi]
AB  - Translational research is now a critically important current in academic
      medicine. Researchers in all health-related fields are being encouraged not only 
      to demonstrate the potential benefits of their research but also to help identify
      the steps through which their research might be 'made practical'. This paper
      considers the prospects of a corresponding movement of 'translational ethics'.
      Some of the advantages and disadvantages of focusing upon the translation of
      ethical scholarship are reviewed. While emphasising the difficulties of crossing 
      the gap between scholarship and practice, the paper concludes that a debate about
      the business of translation would be useful for medical ethics.
FAU - Cribb, Alan
AU  - Cribb A
AD  - Centre for Public Policy, King's College London, Franklin-Wilkins Building WBW,
      Waterloo Road, London SE1 9NN, UK. alan.cribb@kcl.ac.uk
LA  - eng
GR  - 086034/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Biomedical Research/ethics/methods/*standards
MH  - *Ethics, Medical
MH  - Fellowships and Scholarships
MH  - Humans
MH  - Translational Research, Biomedical/ethics/methods/*standards
EDAT- 2010/03/27 06:00
MHDA- 2011/10/21 06:00
CRDT- 2010/03/27 06:00
PHST- 2010/03/27 06:00 [entrez]
PHST- 2010/03/27 06:00 [pubmed]
PHST- 2011/10/21 06:00 [medline]
AID - 36/4/207 [pii]
AID - 10.1136/jme.2009.029785 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Apr;36(4):207-10. doi: 10.1136/jme.2009.029785.


PMID- 20338906
OWN - NLM
STAT- MEDLINE
DCOM- 20100621
LR  - 20220410
IS  - 1740-7753 (Electronic)
IS  - 1740-7745 (Linking)
VI  - 7
IP  - 2
DP  - 2010 Apr
TI  - Sequential meta-analysis: an efficient decision-making tool.
PG  - 136-46
LID - 10.1177/1740774509360994 [doi]
AB  - BACKGROUND: A cumulative meta-analysis of successive randomized controlled trials
      (RCTs) can be used to decide whether enough evidence has been obtained comparing 
      a control and an intervention treatment or whether a new RCT should be initiated.
      In general, no adjustment is made for repeatedly testing the null hypothesis of
      treatment equivalence on cumulative data. Neither can the power of the
      statistical test be quantified. Recently, trial sequential analysis (TSA) was
      suggested to '. . . establish when firm evidence is reached in cumulative
      meta-analysis'. TSA is based on alpha-spending functions and necessitates a prior
      estimate of the total information size. Various information sizes were suggested.
      PURPOSE: The aim of this study is to compare TSA with sequential meta-analysis
      (SMA) following Whitehead's boundaries approach. METHODS: We compare TSA and SMA 
      by re-analysis of a number of published examples. RESULTS: Re-analysis of the
      examples shows that for an SMA: (1) no prior estimate for total information size 
      is necessary and thus one set of boundaries suffices; (2) stopping a cumulative
      meta-analysis for futility is an option; (3) the power can be quantified; (4)
      point and interval estimates are adjusted for the multiple testing; and (5) gains
      in efficiency can be achieved, both for efficacy and for futility and thus
      ethical and economical benefits can be obtained. LIMITATIONS: Estimates for
      between-trial variability are unstable for a small number of trials. The behavior
      of a newly proposed estimate should be subject of further investigation.
      CONCLUSION: SMA is a useful tool to investigate the cumulative evidence from
      successive RCTs.
FAU - van der Tweel, Ingeborg
AU  - van der Tweel I
AD  - Department of Biostatistics, Julius Center, University Medical Center, Utrecht,
      The Netherlands. i.vandertweel@umcutrecht.nl
FAU - Bollen, Casper
AU  - Bollen C
LA  - eng
PT  - Journal Article
DEP - 20100325
PL  - England
TA  - Clin Trials
JT  - Clinical trials (London, England)
JID - 101197451
SB  - IM
CIN - Clin Trials. 2010 Dec;7(6):752-3; author reply 754. PMID: 21138922
MH  - *Decision Support Techniques
MH  - Humans
MH  - *Meta-Analysis as Topic
MH  - Randomized Controlled Trials as Topic/*methods
MH  - Research Design
MH  - Selection Bias
EDAT- 2010/03/27 06:00
MHDA- 2010/06/22 06:00
CRDT- 2010/03/27 06:00
PHST- 2010/03/27 06:00 [entrez]
PHST- 2010/03/27 06:00 [pubmed]
PHST- 2010/06/22 06:00 [medline]
AID - 1740774509360994 [pii]
AID - 10.1177/1740774509360994 [doi]
PST - ppublish
SO  - Clin Trials. 2010 Apr;7(2):136-46. doi: 10.1177/1740774509360994. Epub 2010 Mar
      25.


PMID- 20338054
OWN - NLM
STAT- MEDLINE
DCOM- 20100510
LR  - 20220408
IS  - 1471-2334 (Electronic)
IS  - 1471-2334 (Linking)
VI  - 10
DP  - 2010 Mar 25
TI  - Does treatment of intestinal helminth infections influence malaria? Background
      and methodology of a longitudinal study of clinical, parasitological and
      immunological parameters in Nangapanda, Flores, Indonesia (ImmunoSPIN Study).
PG  - 77
LID - 10.1186/1471-2334-10-77 [doi]
AB  - BACKGROUND: Given that helminth infections are thought to have strong
      immunomodulatory activity, the question whether helminth infections might affect 
      responses to malaria antigens needs to be addressed. Different cross-sectional
      studies using diverse methodologies have reported that helminth infections might 
      either exacerbate or reduce the severity of malaria attacks. The same
      discrepancies have been reported for parasitemia. METHODS/DESIGN: To determine
      the effect of geohelminth infections and their treatment on malaria infection and
      disease outcome, as well as on immunological parameters, the area of Nangapanda
      on Flores Island, Indonesia, where malaria and helminth parasites are co-endemic 
      was selected for a longitudinal study. Here a Double-blind randomized trial will 
      be performed, incorporating repeated treatment with albendazole (400 mg) or
      placebo at three monthly intervals. Household characteristic data, anthropometry,
      the presence of intestinal helminth and Plasmodium spp infections, and the
      incidence of malaria episodes are recorded. In vitro cultures of whole blood,
      stimulated with a number of antigens, mitogens and toll like receptor ligands
      provide relevant immunological parameters at baseline and following 1 and 2 years
      of treatment rounds. The primary outcome of the study is the prevalence of
      Plasmodium falciparum and P. vivax infection. The secondary outcome will be
      incidence and severity of malaria episodes detected via both passive and active
      follow-up. The tertiary outcome is the inflammatory cytokine profile in response 
      to parasite antigens. The project also facilitates the transfer of state of the
      art methodologies and technologies, molecular diagnosis of parasitic diseases,
      immunology and epidemiology from Europe to Indonesia. DISCUSSION: The study will 
      provide data on the effect of helminth infections on malaria. It will also give
      information on anthelminthic treatment efficacy and effectiveness and could help 
      develop evidence-based policymaking. TRIAL REGISTRATION: This study was approved 
      by The Ethical Committee of Faculty of Medicine, University of Indonesia,
      ref:194/PT02.FK/Etik/2006 and has been filed by ethics committee of the Leiden
      University Medical Center. CLINICAL TRIAL NUMBER: ISRCTN83830814. The study is
      reported in accordance with the CONSORT guidelines for cluster-randomized
      studies.
FAU - Wiria, Aprilianto E
AU  - Wiria AE
AD  - Department of Parasitology, Faculty of Medicine, University of Indonesia,
      Jakarta, Indonesia.
FAU - Prasetyani, Margaretta A
AU  - Prasetyani MA
FAU - Hamid, Firdaus
AU  - Hamid F
FAU - Wammes, Linda J
AU  - Wammes LJ
FAU - Lell, Bertrand
AU  - Lell B
FAU - Ariawan, Iwan
AU  - Ariawan I
FAU - Uh, Hae Won
AU  - Uh HW
FAU - Wibowo, Heri
AU  - Wibowo H
FAU - Djuardi, Yenny
AU  - Djuardi Y
FAU - Wahyuni, Sitti
AU  - Wahyuni S
FAU - Sutanto, Inge
AU  - Sutanto I
FAU - May, Linda
AU  - May L
FAU - Luty, Adrian J F
AU  - Luty AJ
FAU - Verweij, Jaco J
AU  - Verweij JJ
FAU - Sartono, Erliyani
AU  - Sartono E
FAU - Yazdanbakhsh, Maria
AU  - Yazdanbakhsh M
FAU - Supali, Taniawati
AU  - Supali T
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20100325
PL  - England
TA  - BMC Infect Dis
JT  - BMC infectious diseases
JID - 100968551
RN  - 0 (Anthelmintics)
RN  - 0 (Cytokines)
RN  - 0 (Placebos)
RN  - F4216019LN (Albendazole)
SB  - IM
MH  - Albendazole/administration & dosage/*therapeutic use
MH  - Animals
MH  - Anthelmintics/administration & dosage/*therapeutic use
MH  - Cytokines/metabolism
MH  - Double-Blind Method
MH  - Helminthiasis/*drug therapy
MH  - Incidence
MH  - Indonesia/epidemiology
MH  - Intestinal Diseases, Parasitic/*drug therapy
MH  - Leukocytes, Mononuclear/immunology
MH  - Longitudinal Studies
MH  - Malaria, Falciparum/epidemiology/immunology/*pathology
MH  - Malaria, Vivax/epidemiology/immunology/*pathology
MH  - Placebos/administration & dosage
MH  - Plasmodium falciparum/isolation & purification
MH  - Plasmodium vivax/isolation & purification
MH  - Prevalence
PMC - PMC2859773
EDAT- 2010/03/27 06:00
MHDA- 2010/05/11 06:00
CRDT- 2010/03/27 06:00
PHST- 2009/12/18 00:00 [received]
PHST- 2010/03/25 00:00 [accepted]
PHST- 2010/03/27 06:00 [entrez]
PHST- 2010/03/27 06:00 [pubmed]
PHST- 2010/05/11 06:00 [medline]
AID - 1471-2334-10-77 [pii]
AID - 10.1186/1471-2334-10-77 [doi]
PST - epublish
SO  - BMC Infect Dis. 2010 Mar 25;10:77. doi: 10.1186/1471-2334-10-77.


PMID- 20337799
OWN - NLM
STAT- MEDLINE
DCOM- 20100805
LR  - 20220408
IS  - 1365-2648 (Electronic)
IS  - 0309-2402 (Linking)
VI  - 66
IP  - 5
DP  - 2010 May
TI  - The relationship between organizational justice and workplace aggression.
PG  - 1169-82
LID - 10.1111/j.1365-2648.2010.05281.x [doi]
AB  - AIM: This paper is a discussion of the links between organizational justice and
      workplace aggression. BACKGROUND: Managers have been identified as key players in
      implementing and maintaining an organizational culture of trust and justice.
      Employees who perceive themselves to be victims of injustice may rebel, using
      various means to 'punish' the source of the injustice. DATA SOURCES: Literature
      review of publications in English and French from the early 1960 to 2009,
      including books, was conducted. Bibliographic databases searched for journal
      articles were Cumulative Index to Nursing and Allied Health Literature, Current
      Content, EMBASE, Medline, PsycINFO and Web of Science. DISCUSSION: The work
      environment and roles of nursing managers have changed considerably in the last
      20 years, resulting in challenging working conditions for nursing managers. These
      can have an impact on their ability to create a trusting and fair culture, and
      can mean that they themselves be considered victims of organizational injustice. 
      IMPLICATIONS FOR NURSING: The failure of many re-engineering projects has been
      linked to a lack of consideration of the impact of perception of justice when
      implementing change. In addition, perception of organizational justice has the
      potential to influence many organizational outcomes, such as perception of
      respect and trust. As justice is a founding principle of biomedical ethics,
      principles of justice, equity and fairness must be upheld in practice in
      accordance with the requirements of professional codes of ethics. CONCLUSION: The
      concept of justice is linked to the founding principles of biomedical ethics, and
      these must be upheld in order to practise in accordance with professional codes
      of ethics and conduct.
FAU - St-Pierre, Isabelle
AU  - St-Pierre I
AD  - Faculty of Health Sciences, School of Nursing, University of Ottawa, Ontario,
      Canada. i.stpierre@sympatico.ca
FAU - Holmes, Dave
AU  - Holmes D
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100322
PL  - England
TA  - J Adv Nurs
JT  - Journal of advanced nursing
JID - 7609811
SB  - IM
MH  - Aggression/*psychology
MH  - Humans
MH  - Nurse Administrators
MH  - Nurse's Role
MH  - *Organizational Culture
MH  - *Social Justice/ethics
MH  - Trust
MH  - Workplace/*organization & administration/*psychology
RF  - 55
EDAT- 2010/03/27 06:00
MHDA- 2010/08/06 06:00
CRDT- 2010/03/27 06:00
PHST- 2010/03/27 06:00 [entrez]
PHST- 2010/03/27 06:00 [pubmed]
PHST- 2010/08/06 06:00 [medline]
AID - JAN5281 [pii]
AID - 10.1111/j.1365-2648.2010.05281.x [doi]
PST - ppublish
SO  - J Adv Nurs. 2010 May;66(5):1169-82. doi: 10.1111/j.1365-2648.2010.05281.x. Epub
      2010 Mar 22.


PMID- 20337687
OWN - NLM
STAT- MEDLINE
DCOM- 20100927
LR  - 20100628
IS  - 1523-1739 (Electronic)
IS  - 0888-8892 (Linking)
VI  - 24
IP  - 3
DP  - 2010 Jun
TI  - Biophilia as a universal ethic for conserving biodiversity.
PG  - 903-6
LID - 10.1111/j.1523-1739.2010.01485.x [doi]
FAU - Simaika, John P
AU  - Simaika JP
AD  - Department of Conservation Ecology and Entomology, Stellenbosch University,
      Matieland 7602, South Africa.
FAU - Samways, Michael J
AU  - Samways MJ
LA  - eng
PT  - Journal Article
DEP - 20100319
PL  - United States
TA  - Conserv Biol
JT  - Conservation biology : the journal of the Society for Conservation Biology
JID - 9882301
SB  - IM
MH  - Animals
MH  - Attitude
MH  - *Biodiversity
MH  - *Conservation of Natural Resources
MH  - *Ethics
MH  - Humans
EDAT- 2010/03/27 06:00
MHDA- 2010/09/29 06:00
CRDT- 2010/03/27 06:00
PHST- 2010/03/27 06:00 [entrez]
PHST- 2010/03/27 06:00 [pubmed]
PHST- 2010/09/29 06:00 [medline]
AID - CBI1485 [pii]
AID - 10.1111/j.1523-1739.2010.01485.x [doi]
PST - ppublish
SO  - Conserv Biol. 2010 Jun;24(3):903-6. doi: 10.1111/j.1523-1739.2010.01485.x. Epub
      2010 Mar 19.


PMID- 20336981
OWN - NLM
STAT- MEDLINE
DCOM- 20100416
LR  - 20100326
IS  - 1092-0811 (Print)
IS  - 1092-0811 (Linking)
VI  - 19
IP  - 1
DP  - 2010 Jan-Feb
TI  - Nursing care for the patient with co-existing pain and substance misuse: meeting 
      the patient's needs.
PG  - 25-30, 53; quiz 31
AB  - Meeting the needs of the patient with co-existing pain and substance misuse is a 
      complex ethical issue. As advocates for the patient, nurses participate in
      developing a patient-centered approach to care.
FAU - Finney, Leanne
AU  - Finney L
AD  - St. Francis Health Center, Sisters of Charity of Leavenworth Health System,
      Topeka, KS, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medsurg Nurs
JT  - Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses
JID - 9300545
MH  - Health Services Needs and Demand/ethics
MH  - Humans
MH  - *Nurse's Role
MH  - Nursing Assessment
MH  - Pain/complications/diagnosis/*prevention & control
MH  - Pain Measurement
MH  - *Patient Advocacy/ethics/legislation & jurisprudence
MH  - *Patient-Centered Care/ethics/organization & administration
MH  - Principle-Based Ethics
MH  - Substance-Related Disorders/complications/diagnosis/*prevention & control
MH  - United States
EDAT- 2010/03/27 06:00
MHDA- 2010/04/17 06:00
CRDT- 2010/03/27 06:00
PHST- 2010/03/27 06:00 [entrez]
PHST- 2010/03/27 06:00 [pubmed]
PHST- 2010/04/17 06:00 [medline]
PST - ppublish
SO  - Medsurg Nurs. 2010 Jan-Feb;19(1):25-30, 53; quiz 31.


PMID- 20336975
OWN - NLM
STAT- MEDLINE
DCOM- 20100504
LR  - 20100326
IS  - 1946-4967 (Print)
IS  - 1946-4967 (Linking)
VI  - 39
IP  - 3
DP  - 2010 Mar
TI  - Professional development. Part 3: How to adhere to a code of ethics in EMS.
PG  - 75-6
FAU - Touchstone, Michael
AU  - Touchstone M
AD  - Philadelphia Fire Department, USA. m-touch@comcast.net
LA  - eng
PT  - Journal Article
PL  - United States
TA  - EMS Mag
JT  - EMS magazine
JID - 101466002
MH  - *Codes of Ethics
MH  - *Emergency Medical Technicians
MH  - *Guideline Adherence
MH  - Humans
EDAT- 2010/03/27 06:00
MHDA- 2010/05/05 06:00
CRDT- 2010/03/27 06:00
PHST- 2010/03/27 06:00 [entrez]
PHST- 2010/03/27 06:00 [pubmed]
PHST- 2010/05/05 06:00 [medline]
PST - ppublish
SO  - EMS Mag. 2010 Mar;39(3):75-6.


PMID- 20336958
OWN - NLM
STAT- MEDLINE
DCOM- 20100601
LR  - 20100326
IS  - 0024-6921 (Print)
IS  - 0024-6921 (Linking)
VI  - 162
IP  - 1
DP  - 2010 Jan-Feb
TI  - Organ donation by a prisoner: legal and ethical considerations.
PG  - 44-6
AB  - The supply of available organs for donation is limited. In this article we
      describe the legal and ethical principles surrounding donation of organs from a
      prisoner.
FAU - Bagatell, Stuart J
AU  - Bagatell SJ
AD  - Miller School of Medicine University of Miami, Florida Atlantic University,
      Internal Medicine Residency, JFK Medical Center, Atlantis, USA.
FAU - Owens, Donald P
AU  - Owens DP
FAU - Kahn, Marc J
AU  - Kahn MJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J La State Med Soc
JT  - The Journal of the Louisiana State Medical Society : official organ of the
      Louisiana State Medical Society
JID - 7505618
SB  - IM
MH  - Humans
MH  - Informed Consent/ethics/legislation & jurisprudence
MH  - Patient Selection/ethics
MH  - *Prisoners
MH  - Tissue Donors/*ethics/*legislation & jurisprudence
MH  - Tissue and Organ Procurement/*ethics/*legislation & jurisprudence
EDAT- 2010/03/27 06:00
MHDA- 2010/06/02 06:00
CRDT- 2010/03/27 06:00
PHST- 2010/03/27 06:00 [entrez]
PHST- 2010/03/27 06:00 [pubmed]
PHST- 2010/06/02 06:00 [medline]
PST - ppublish
SO  - J La State Med Soc. 2010 Jan-Feb;162(1):44-6.


PMID- 20336954
OWN - NLM
STAT- MEDLINE
DCOM- 20100601
LR  - 20100326
IS  - 0024-6921 (Print)
IS  - 0024-6921 (Linking)
VI  - 162
IP  - 1
DP  - 2010 Jan-Feb
TI  - Ethics in the primary care office.
PG  - 26-32
AB  - Thirty-one doctors completed surveys on perceived ethical issues in their office 
      and then evaluated each office visit for a single day, yielding a total of 644
      patient encounters. Overall, 33% of office visits involved an ethical issue of
      some type. Prescription related issues were the most common type of problem
      encountered.
FAU - Rolfsen, Michael L
AU  - Rolfsen ML
AD  - LSU School of Medicine, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J La State Med Soc
JT  - The Journal of the Louisiana State Medical Society : official organ of the
      Louisiana State Medical Society
JID - 7505618
SB  - IM
MH  - Adult
MH  - Aged
MH  - Drug Prescriptions
MH  - Female
MH  - Health Care Surveys
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Office Visits
MH  - Physician-Patient Relations/*ethics
MH  - Primary Health Care/*ethics
MH  - Professional Practice/*ethics
EDAT- 2010/03/27 06:00
MHDA- 2010/06/02 06:00
CRDT- 2010/03/27 06:00
PHST- 2010/03/27 06:00 [entrez]
PHST- 2010/03/27 06:00 [pubmed]
PHST- 2010/06/02 06:00 [medline]
PST - ppublish
SO  - J La State Med Soc. 2010 Jan-Feb;162(1):26-32.


PMID- 20233388
OWN - NLM
STAT- MEDLINE
DCOM- 20100615
LR  - 20181113
IS  - 1471-2393 (Electronic)
IS  - 1471-2393 (Linking)
VI  - 10 Suppl 1
DP  - 2010 Feb 23
TI  - Global report on preterm birth and stillbirth (7 of 7): mobilizing resources to
      accelerate innovative solutions (Global Action Agenda).
PG  - S7
LID - 10.1186/1471-2393-10-S1-S7 [doi]
AB  - BACKGROUND: Preterm birth and stillbirth are complex local and global health
      problems requiring an interdisciplinary approach and an international commitment.
      Stakeholders developed recommendations for a Global Action Agenda (GAA) at the
      2009 International Conference on Prematurity and Stillbirth. The primary goal of 
      this GAA is to forge a collaborative effort toward achieving common goals to
      prevent preterm birth and stillbirth, and to improve related maternal, newborn,
      and child health outcomes. CONFERENCE PARTICIPANTS: GAPPS co-convened this
      four-day conference with the Bill & Melinda Gates Foundation, March of Dimes,
      PATH, Save the Children, UNICEF and the World Health Organization. Participants
      included about 200 leading international researchers, policymakers, health care
      practitioners and philanthropists. A near-final draft of this report was sent
      three weeks in advance to help co-chairs and participants prepare for workgroup
      discussions. GLOBAL ACTION AGENDA: Twelve thematic workgroups, composed of
      interdisciplinary experts, made recommendations on short-, intermediate-, and
      long-term milestones, and success metrics. Recommendations are based on the
      following themes: (1) advance discovery of the magnitude, causes and innovative
      solutions; (2) promote development and delivery of low-cost, proven
      interventions; (3) improve advocacy efforts to increase awareness that preterm
      birth and stillbirth are leading contributors to the global health burden; (4)
      increase resources for research and implementation; and (5) consider ethical and 
      social justice implications throughout all efforts. SUMMARY: The conference
      provided an unprecedented opportunity for maternal, newborn and child health
      stakeholders to create a collaborative strategy for addressing preterm birth and 
      stillbirth globally. Participants and others have already completed or launched
      work on key milestones identified in the GAA. Updates will be provided at
      www.gapps.org.
FAU - Rubens, Craig E
AU  - Rubens CE
AD  - Global Alliance to Prevent Prematurity and Stillbirth, an initiative of Seattle
      Children's, Seattle, Washington, USA. craig.rubens@seattlechildrens.org
FAU - Gravett, Michael G
AU  - Gravett MG
FAU - Victora, Cesar G
AU  - Victora CG
FAU - Nunes, Toni M
AU  - Nunes TM
CN  - GAPPS Review Group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100223
PL  - England
TA  - BMC Pregnancy Childbirth
JT  - BMC pregnancy and childbirth
JID - 100967799
SB  - IM
MH  - Female
MH  - Fetal Death/*prevention & control
MH  - *Global Health
MH  - Humans
MH  - Infant, Newborn
MH  - *International Cooperation
MH  - Pregnancy
MH  - Premature Birth/*prevention & control
MH  - *Stillbirth
RF  - 6
PMC - PMC2841775
IR  - Barros FC
FIR - Barros, Fernando C
IR  - Batra M
FIR - Batra, Maneesh
IR  - Bhutta ZA
FIR - Bhutta, Zulfiqar Ahmed
IR  - Fajon AV
FIR - Fajon, Anne-Veronique
IR  - Gravett MG
FIR - Gravett, Michael G
IR  - Hansen TN
FIR - Hansen, Thomas N
IR  - Kelley M
FIR - Kelley, Maureen
IR  - Lawn JE
FIR - Lawn, Joy E
IR  - Nunes TM
FIR - Nunes, Toni M
IR  - Rubens CE
FIR - Rubens, Craig E
IR  - Sather M
FIR - Sather, Megan
IR  - Stanton C
FIR - Stanton, Cynthia
IR  - Victora CG
FIR - Victora, Cesar G
IR  - Zaentz R
FIR - Zaentz, Rachel
EDAT- 2010/03/27 06:00
MHDA- 2010/06/16 06:00
CRDT- 2010/03/18 06:00
PHST- 2010/03/18 06:00 [entrez]
PHST- 2010/03/27 06:00 [pubmed]
PHST- 2010/06/16 06:00 [medline]
AID - 1471-2393-10-S1-S7 [pii]
AID - 10.1186/1471-2393-10-S1-S7 [doi]
PST - epublish
SO  - BMC Pregnancy Childbirth. 2010 Feb 23;10 Suppl 1:S7. doi:
      10.1186/1471-2393-10-S1-S7.


PMID- 20233387
OWN - NLM
STAT- MEDLINE
DCOM- 20100615
LR  - 20181113
IS  - 1471-2393 (Electronic)
IS  - 1471-2393 (Linking)
VI  - 10 Suppl 1
DP  - 2010 Feb 23
TI  - Global report on preterm birth and stillbirth (6 of 7): ethical considerations.
PG  - S6
LID - 10.1186/1471-2393-10-S1-S6 [doi]
AB  - INTRODUCTION: Despite the substantial global burden of preterm and stillbirth,
      little attention has been given to the ethical considerations related to research
      and interventions in the global context. Ethical dilemmas surrounding
      reproductive decisions and the care of preterm newborns impact the delivery of
      interventions, and are not well understood in low-resource settings. Issues such 
      as how to address the moral and cultural attitudes surrounding stillbirths, have 
      cross-cutting implications for global visibility of the disease burden. This
      analysis identifies ethical issues impacting definitions, discovery, development,
      and delivery of effective interventions to decrease the global burden of preterm 
      birth and stillbirth. METHODS: This review is based on a comprehensive literature
      review; an ethical analysis of other articles within this global report; and
      discussions with GAPPS's Scientific Advisory Council, team of international
      investigators, and a community of international experts on maternal, newborn, and
      child health and bioethics from the 2009 International Conference on Prematurity 
      and Stillbirth. The literature review includes articles in PubMed, Academic
      Search Complete (EBSCO), and Philosopher's Index with a range of 1995-2008.
      RESULTS: Advancements in discovery science relating to preterm birth and
      stillbirth require careful consideration in the design and use of repositories
      containing maternal specimens and data. Equally important is the need to improve 
      clinical translation from basic science research to delivery of interventions,
      and to ensure global needs inform discovery science agenda-setting. Ethical
      issues in the development of interventions include a need to balance immediate
      versus long-term impacts--such as caring for preterm newborns rather than
      preventing preterm births. The delivery of interventions must address: women's
      health disparities as determinants of preterm birth and stillbirth; improving
      measurements of impact on equity in coverage; balancing maternal and newborn
      outcomes in choosing interventions; and understanding the personal and
      cross-cultural experiences of preterm birth and stillbirth among women, families 
      and communities. CONCLUSION: Efforts to improve visibility, funding, research and
      the successful delivery of interventions for preterm birth and stillbirth face a 
      number of ethical concerns. Thoughtful input from those in health policy,
      bioethics and international research ethics helped shape an interdisciplinary
      global action agenda to prevent preterm birth and stillbirth.
FAU - Kelley, Maureen
AU  - Kelley M
AD  - Department of Pediatrics, Bioethics Division, University of Washington School of 
      Medicine, Seattle Children's Hospital, Seattle, Washington, USA.
      mckelley@uwashington.edu
FAU - Rubens, Craig E
AU  - Rubens CE
CN  - GAPPS Review Group
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100223
PL  - England
TA  - BMC Pregnancy Childbirth
JT  - BMC pregnancy and childbirth
JID - 100967799
SB  - IM
MH  - Biomedical Research
MH  - Data Collection
MH  - Developing Countries
MH  - *Ethics
MH  - Female
MH  - *Fetal Death/epidemiology
MH  - Health Services Accessibility
MH  - Healthcare Disparities
MH  - Humans
MH  - Infant, Newborn
MH  - Pregnancy
MH  - *Premature Birth/epidemiology
MH  - Prenatal Care
MH  - Socioeconomic Factors
MH  - *Stillbirth
RF  - 91
PMC - PMC2841776
IR  - Barros FC
FIR - Barros, Fernando C
IR  - Batra M
FIR - Batra, Maneesh
IR  - Bhutta ZA
FIR - Bhutta, Zulfiqar Ahmed
IR  - Fajon AV
FIR - Fajon, Anne-Veronique
IR  - Gravett MG
FIR - Gravett, Michael G
IR  - Hansen TN
FIR - Hansen, Thomas N
IR  - Kelley M
FIR - Kelley, Maureen
IR  - Lawn JE
FIR - Lawn, Joy E
IR  - Nunes TM
FIR - Nunes, Toni M
IR  - Rubens CE
FIR - Rubens, Craig E
IR  - Sather M
FIR - Sather, Megan
IR  - Stanton C
FIR - Stanton, Cynthia
IR  - Victora CG
FIR - Victora, Cesar G
IR  - Zaentz R
FIR - Zaentz, Rachel
EDAT- 2010/03/27 06:00
MHDA- 2010/06/16 06:00
CRDT- 2010/03/18 06:00
PHST- 2010/03/18 06:00 [entrez]
PHST- 2010/03/27 06:00 [pubmed]
PHST- 2010/06/16 06:00 [medline]
AID - 1471-2393-10-S1-S6 [pii]
AID - 10.1186/1471-2393-10-S1-S6 [doi]
PST - epublish
SO  - BMC Pregnancy Childbirth. 2010 Feb 23;10 Suppl 1:S6. doi:
      10.1186/1471-2393-10-S1-S6.


PMID- 20233386
OWN - NLM
STAT- MEDLINE
DCOM- 20100615
LR  - 20181113
IS  - 1471-2393 (Electronic)
IS  - 1471-2393 (Linking)
VI  - 10 Suppl 1
DP  - 2010 Feb 23
TI  - Global report on preterm birth and stillbirth (5 of 7): advocacy barriers and
      opportunities.
PG  - S5
LID - 10.1186/1471-2393-10-S1-S5 [doi]
AB  - BACKGROUND: Efforts to achieve the Millennium Development Goals (MDGs) to improve
      maternal and child health can be accelerated by addressing preterm birth and
      stillbirth. However, most global health stakeholders are unaware of the
      inextricable connections of these adverse pregnancy outcomes to maternal, newborn
      and child health (MNCH). Improved visibility of preterm births and stillbirths
      will help fuel investments and strengthen commitments in the discovery,
      development and delivery of low-cost solutions globally. This article addresses
      potential barriers and opportunities to increasing global awareness and
      understanding. METHODS: Qualitative research was conducted to analyze current
      knowledge, attitudes and commitments toward preterm birth and stillbirth;
      identify advocacy challenges; and learn more about examples of programs that
      successfully advocate for research and appropriate interventions. Forty-one
      individuals from 14 countries on six continents were interviewed. They included
      maternal, newborn, and child health advocates and implementers, United Nations
      agency representatives, policymakers, researchers, and private and government
      donors. RESULTS: A common recognition of three advocacy challenges with regard to
      preterm birth and stillbirth emerged from these interviews: (1) lack of data
      about the magnitude and impact; (2) lack of awareness and understanding; and (3) 
      lack of low-cost, effective and scalable interventions. Participants also
      identified advocacy opportunities. The first of these opportunities involves
      linking preterm birth and stillbirth to the MDGs, adding these outcomes to
      broader global health discussions and advocacy efforts, and presenting a united
      voice among advocates in the context of broader MNCH issues when addressing
      preterm birth and stillbirth. Another key opportunity is putting a human face to 
      these tragedies--such as a parent who can speak to the personal impact on the
      family. Lastly, several interviewees suggested identifying and engaging champions
      to garner additional visibility and strengthen efforts. Ideal champions will work
      collaboratively with these and other maternal, newborn and child health issues.
      CONCLUSION: Advocacy efforts to add preterm births and stillbirths to broader
      MNCH goals, such as the MDGs, and to identify champions for these issues, will
      accelerate interdisciplinary efforts to reduce these adverse outcomes. The next
      article in this report presents an overview of related ethical considerations.
FAU - Sather, Megan
AU  - Sather M
AD  - GMMB, 1010 Wisconsin Ave, NW, Suite 800, Washington, DC 20007, USA.
FAU - Fajon, Anne-Veronique
AU  - Fajon AV
FAU - Zaentz, Rachel
AU  - Zaentz R
FAU - Rubens, Craig E
AU  - Rubens CE
CN  - GAPPS Review Group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100223
PL  - England
TA  - BMC Pregnancy Childbirth
JT  - BMC pregnancy and childbirth
JID - 100967799
SB  - IM
MH  - Attitude
MH  - Biomedical Research
MH  - Cost of Illness
MH  - Culture
MH  - Data Collection
MH  - Developing Countries
MH  - Female
MH  - *Global Health
MH  - Humans
MH  - Infant Care
MH  - Infant, Newborn
MH  - Interviews as Topic
MH  - Maternal Health Services
MH  - Patient Advocacy
MH  - Pregnancy
MH  - *Premature Birth/psychology
MH  - *Stillbirth/psychology
RF  - 9
PMC - PMC2841773
IR  - Barros FC
FIR - Barros, Fernando C
IR  - Batra M
FIR - Batra, Maneesh
IR  - Bhutta ZA
FIR - Bhutta, Zulfiqar Ahmed
IR  - Fajon AV
FIR - Fajon, Anne-Veronique
IR  - Gravett MG
FIR - Gravett, Michael G
IR  - Hansen TN
FIR - Hansen, Thomas N
IR  - Kelley M
FIR - Kelley, Maureen
IR  - Lawn JE
FIR - Lawn, Joy E
IR  - Nunes TM
FIR - Nunes, Toni M
IR  - Rubens CE
FIR - Rubens, Craig E
IR  - Sather M
FIR - Sather, Megan
IR  - Stanton C
FIR - Stanton, Cynthia
IR  - Victora CG
FIR - Victora, Cesar G
IR  - Zaentz R
FIR - Zaentz, Rachel
EDAT- 2010/03/27 06:00
MHDA- 2010/06/16 06:00
CRDT- 2010/03/18 06:00
PHST- 2010/03/18 06:00 [entrez]
PHST- 2010/03/27 06:00 [pubmed]
PHST- 2010/06/16 06:00 [medline]
AID - 1471-2393-10-S1-S5 [pii]
AID - 10.1186/1471-2393-10-S1-S5 [doi]
PST - epublish
SO  - BMC Pregnancy Childbirth. 2010 Feb 23;10 Suppl 1:S5. doi:
      10.1186/1471-2393-10-S1-S5.


PMID- 20336229
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 1754-9973 (Print)
IS  - 1754-9973 (Linking)
VI  - 3
IP  - 1
DP  - 2010 Apr
TI  - When Ethics Survive Where People Do Not.
PG  - 72-77
AB  - The provision of health care service in resource-poor settings is associated with
      a broad set of ethical issues. Devakumar's case discusses the ethical issues
      related to the inability to treat in a cholera clinic patients who do not have
      cholera. This paper gives a closer look on the context in which Devakumar's case 
      took place. It also analyses the potential local and organizational factors that 
      gives rise to ethical dilemmas and aggravate them. It also proposes a framework
      to help in the proactive handling of the factors that leads to ethical dilemmas
      and resolving the ethical issues as they appear. It adopts the four principles of
      autonomy, beneficence, non-maleficence and justice as universal and prima facie
      principles, but with the inclusion of a local understanding of what of each of
      these principles means. It is based on a collaborative approach that involves the
      beneficiaries and other partners in the field to help share information and
      resources, as well as adopting the provision of a wider service to the whole
      community. This is done by asking three basic questions: (a) who are the relevant
      stakeholders? (b) what ought to be the ethical principles in place? and (c) how
      should we take, implement and follow the decision about service provision?
FAU - Hussein, Ghaiath M A
AU  - Hussein GM
AD  - Research Directorate, Federal Ministry of Health , Sudan.
LA  - eng
PT  - Journal Article
DEP - 20100318
PL  - England
TA  - Public Health Ethics
JT  - Public health ethics
JID - 101463048
PMC - PMC2844105
EDAT- 2010/03/26 06:00
MHDA- 2010/03/26 06:01
CRDT- 2010/03/26 06:00
PHST- 2010/03/26 06:00 [entrez]
PHST- 2010/03/26 06:00 [pubmed]
PHST- 2010/03/26 06:01 [medline]
AID - 10.1093/phe/phq003 [doi]
PST - ppublish
SO  - Public Health Ethics. 2010 Apr;3(1):72-77. doi: 10.1093/phe/phq003. Epub 2010 Mar
      18.


PMID- 20336109
OWN - NLM
STAT- MEDLINE
DCOM- 20100408
LR  - 20211020
IS  - 1476-4687 (Electronic)
IS  - 0028-0836 (Linking)
VI  - 464
IP  - 7288
DP  - 2010 Mar 25
TI  - Industry in academia: ethical frameworks would clarify links.
PG  - 486
LID - 10.1038/464486a [doi]
FAU - Yassi, Annalee
AU  - Yassi A
FAU - Dharamsi, Shafik
AU  - Dharamsi S
FAU - Spiegel, Jerry
AU  - Spiegel J
LA  - eng
PT  - Comment
PT  - Letter
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
SB  - IM
CON - Nature. 2010 Feb 25;463(7284):999-1000. PMID: 20182465
MH  - Industry/*standards/trends
MH  - Public-Private Sector Partnerships/*ethics
MH  - Universities/organization & administration/*standards/trends
EDAT- 2010/03/26 06:00
MHDA- 2010/04/09 06:00
CRDT- 2010/03/26 06:00
PHST- 2010/03/26 06:00 [entrez]
PHST- 2010/03/26 06:00 [pubmed]
PHST- 2010/04/09 06:00 [medline]
AID - 464486a [pii]
AID - 10.1038/464486a [doi]
PST - ppublish
SO  - Nature. 2010 Mar 25;464(7288):486. doi: 10.1038/464486a.


PMID- 20336075
OWN - NLM
STAT- MEDLINE
DCOM- 20110414
LR  - 20190221
IS  - 1476-5543 (Electronic)
IS  - 0743-8346 (Linking)
VI  - 31
IP  - 1
DP  - 2011 Jan
TI  - The role of a pediatric ethics committee in the newborn intensive care unit.
PG  - 1-9
LID - 10.1038/jp.2010.39 [doi]
AB  - Institutional Ethics Committees are commonly available in hospitals with newborn 
      intensive care units, and may serve as a valuable resource for staff and parents 
      dealing with difficult ethical decisions. Many clinicians may be unaware of when 
      the committee might be helpful, or how it functions. After a brief historical
      introduction, two cases are presented as illustrations of pediatric ethics
      committee function. The first involves consideration of cardiac surgery for an
      infant with ventricular septal defect and Trisomy 13. The second involves
      disagreement between staff and parents regarding possible provision of
      cardio-pulmonary resuscitation in a terminally ill newborn. Principles and
      considerations often brought to bear in committee deliberations are reviewed for 
      each case. Neonatologists, staff and families should be aware of this potentially
      valuable resource, and are encouraged to use it for situations of moral distress,
      conflict resolution or ethical uncertainty.
FAU - Mercurio, M R
AU  - Mercurio MR
AD  - Department of Pediatric, Yale University School of Medicine, New Haven, CT 06520,
      USA. mark.mercurio@yale.edu
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20100325
PL  - United States
TA  - J Perinatol
JT  - Journal of perinatology : official journal of the California Perinatal
      Association
JID - 8501884
SB  - IM
MH  - Cardiac Surgical Procedures
MH  - Cardiopulmonary Resuscitation
MH  - Chromosome Disorders/complications
MH  - Chromosomes, Human, Pair 13
MH  - Dissent and Disputes
MH  - *Ethics Committees, Clinical
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Septal Defects, Ventricular/complications/surgery
MH  - Humans
MH  - Infant, Newborn
MH  - Intensive Care Units, Neonatal/*ethics
MH  - Male
MH  - Medical Staff, Hospital
MH  - Neonatology/ethics
MH  - Neoplasms/physiopathology/therapy
MH  - Parents
MH  - *Role
MH  - Terminally Ill
MH  - Trisomy
MH  - Trisomy 13 Syndrome
EDAT- 2010/03/26 06:00
MHDA- 2011/04/16 06:00
CRDT- 2010/03/26 06:00
PHST- 2010/03/26 06:00 [entrez]
PHST- 2010/03/26 06:00 [pubmed]
PHST- 2011/04/16 06:00 [medline]
AID - jp201039 [pii]
AID - 10.1038/jp.2010.39 [doi]
PST - ppublish
SO  - J Perinatol. 2011 Jan;31(1):1-9. doi: 10.1038/jp.2010.39. Epub 2010 Mar 25.


PMID- 20335914
OWN - NLM
STAT- MEDLINE
DCOM- 20100505
LR  - 20161125
IS  - 0966-0461 (Print)
IS  - 0966-0461 (Linking)
VI  - 19
IP  - 6
DP  - 2010 Mar 25-Apr 7
TI  - Medical futility in children's nursing: making end-of-life decisions.
PG  - 352-6
AB  - Caring for infants at end of life is challenging and distressing for parents and 
      healthcare professionals, especially in relation to making decisions regarding
      withholding or withdrawal of treatment. The concept of medical futility must be
      considered under these circumstances. Parents and healthcare professionals should
      be involved together in making these difficult decisions. However, for some
      parents, emotions and guilt often are unbearable and, understandably, parents can
      be reluctant to make a decision. Despite the recognition of parental autonomy, if
      parents disagree with a decision made by medical staff, the case will be referred
      to and solved by the courts. The courts' decisions are often based on the best
      interest of the child. In this article, the authors discuss the concepts of
      'parental autonomy' and 'the child's best interests' when determining medical
      futility for infants or neonates. The role of the nurse when caring for the dying
      child and their family is multifaceted. While nurses do not have a legitimate
      role in decision making at the end of life, it is often nurses who, through their
      advocacy role, inform doctors about parents' wishes and it is often nurses who
      support parents during this difficult time. Furthermore, nurses caring for dying 
      children should be familiar to the family, experienced in end-of-life care and
      comfortable talking to parents about death and dying and treatment choices.
      Children's nurses therefore require advanced communication skills and an
      essential understanding of the ethical and legal knowledge relating to medical
      futility in end-of-life children's nursing.
FAU - Brien, Irene O
AU  - Brien IO
AD  - Our Lady's Hospital for Sick Children, Crumlin, Dublin.
FAU - Duffy, Anita
AU  - Duffy A
FAU - Shea, Ellen O
AU  - Shea EO
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Nurs
JT  - British journal of nursing (Mark Allen Publishing)
JID - 9212059
MH  - *Decision Making/ethics
MH  - Human Rights
MH  - Humans
MH  - Infant
MH  - Infant Welfare/*legislation & jurisprudence
MH  - Infant, Newborn
MH  - Ireland
MH  - *Medical Futility
MH  - Nurse's Role
MH  - Parental Consent/*legislation & jurisprudence
MH  - Pediatric Nursing
MH  - *Terminal Care
MH  - United Kingdom
EDAT- 2010/03/26 06:00
MHDA- 2010/05/06 06:00
CRDT- 2010/03/26 06:00
PHST- 2010/03/26 06:00 [entrez]
PHST- 2010/03/26 06:00 [pubmed]
PHST- 2010/05/06 06:00 [medline]
AID - 10.12968/bjon.2010.19.6.47234 [doi]
PST - ppublish
SO  - Br J Nurs. 2010 Mar 25-Apr 7;19(6):352-6. doi: 10.12968/bjon.2010.19.6.47234.


PMID- 20335427
OWN - NLM
STAT- MEDLINE
DCOM- 20100802
LR  - 20220408
IS  - 1748-880X (Electronic)
IS  - 0007-1285 (Linking)
VI  - 83
IP  - 990
DP  - 2010 Jun
TI  - Incidental findings found in "healthy" volunteers during imaging performed for
      research: current legal and ethical implications.
PG  - 456-65
LID - 10.1259/bjr/15877332 [doi]
AB  - Incidental findings found in "healthy" volunteers during research imaging are
      common and have important implications for study design and performance,
      particularly in the areas of informed consent, subjects' rights, clinical image
      analysis and disclosure. In this study, we aimed to determine current practice
      and regulations concerning information that should be given to research subjects 
      when obtaining consent, reporting of research images, who should be informed
      about any incidental findings and the method of disclosure. We reviewed all UK,
      European and international humanitarian, legal and ethical agencies' guidance. We
      found that the guidance on what constitutes incidental pathology, how to
      recognise it and what to do about it is inconsistent between agencies, difficult 
      to find and less complete in the UK than elsewhere. Where given, guidance states 
      that volunteers should be informed during the consent process about how research 
      images will be managed, whether a mechanism exists for identifying incidental
      findings, arrangements for their disclosure, the potential benefit or harm and
      therapeutic options. The effects of incidentally discovered pathology on the
      individual can be complex and far-reaching. Radiologist involvement in analysis
      of research images varies widely; many incidental findings might therefore go
      unrecognised. In conclusion, guidance on the management of research imaging is
      inconsistent, limited and does not address the interests of volunteers. Improved 
      standards to guide management of research images and incidental findings are
      urgently required.
FAU - Booth, T C
AU  - Booth TC
AD  - Royal Free Hospital NHS Trust, Department of Radiology, Pond Street, London, UK. 
      tombooth@doctors.org.uk
FAU - Jackson, A
AU  - Jackson A
FAU - Wardlaw, J M
AU  - Wardlaw JM
FAU - Taylor, S A
AU  - Taylor SA
FAU - Waldman, A D
AU  - Waldman AD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100324
PL  - England
TA  - Br J Radiol
JT  - The British journal of radiology
JID - 0373125
SB  - IM
MH  - *Biomedical Research/ethics/legislation & jurisprudence
MH  - Conflict of Interest
MH  - Diagnostic Imaging/*ethics
MH  - Europe
MH  - Humans
MH  - *Incidental Findings
MH  - *Practice Guidelines as Topic
MH  - Research Subjects/*legislation & jurisprudence
MH  - Truth Disclosure/ethics
MH  - United Kingdom
MH  - United States
RF  - 80
PMC - PMC3473586
EDAT- 2010/03/26 06:00
MHDA- 2010/08/03 06:00
CRDT- 2010/03/26 06:00
PHST- 2010/03/26 06:00 [entrez]
PHST- 2010/03/26 06:00 [pubmed]
PHST- 2010/08/03 06:00 [medline]
AID - 15877332 [pii]
AID - 10.1259/bjr/15877332 [doi]
PST - ppublish
SO  - Br J Radiol. 2010 Jun;83(990):456-65. doi: 10.1259/bjr/15877332. Epub 2010 Mar
      24.


PMID- 20335379
OWN - NLM
STAT- MEDLINE
DCOM- 20100505
LR  - 20170802
IS  - 1535-4970 (Electronic)
IS  - 1073-449X (Linking)
VI  - 181
IP  - 7
DP  - 2010 Apr 1
TI  - Genetics, ethics, and the use of long-acting beta-adrenergics to treat asthma.
PG  - 647-8
LID - 10.1164/rccm.200912-1890ED [doi]
FAU - Martinez, Fernando D
AU  - Martinez FD
FAU - Fabbri, Leonardo M
AU  - Fabbri LM
LA  - eng
PT  - Comment
PT  - Editorial
PL  - United States
TA  - Am J Respir Crit Care Med
JT  - American journal of respiratory and critical care medicine
JID - 9421642
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Adrenergic beta-Agonists)
RN  - 0 (Bronchodilator Agents)
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Receptors, Adrenergic, beta-2)
SB  - IM
CON - Am J Respir Crit Care Med. 2010 Apr 1;181(7):676-87. PMID: 19910613
CIN - Am J Respir Crit Care Med. 2010 Apr 1;181(7):648-50. PMID: 20335380
MH  - Administration, Inhalation
MH  - Adrenal Cortex Hormones/administration & dosage
MH  - Adrenergic beta-Agonists/*administration & dosage/adverse effects
MH  - Asthma/*drug therapy/*genetics
MH  - Bronchodilator Agents/administration & dosage/adverse effects
MH  - Child
MH  - Clinical Trials as Topic/*ethics
MH  - Delayed-Action Preparations
MH  - Humans
MH  - Pharmacogenetics
MH  - Polymorphism, Genetic
MH  - Receptors, Adrenergic, beta-2/*genetics
EDAT- 2010/03/26 06:00
MHDA- 2010/05/06 06:00
CRDT- 2010/03/26 06:00
PHST- 2010/03/26 06:00 [entrez]
PHST- 2010/03/26 06:00 [pubmed]
PHST- 2010/05/06 06:00 [medline]
AID - 181/7/647 [pii]
AID - 10.1164/rccm.200912-1890ED [doi]
PST - ppublish
SO  - Am J Respir Crit Care Med. 2010 Apr 1;181(7):647-8. doi:
      10.1164/rccm.200912-1890ED.


PMID- 20334761
OWN - NLM
STAT- MEDLINE
DCOM- 20100505
LR  - 20191210
IS  - 0156-5788 (Print)
IS  - 0156-5788 (Linking)
VI  - 34
IP  - 1
DP  - 2010 Mar
TI  - Treating an unhealthy organisational culture: the implications of the Bundaberg
      Hospital Inquiry for managerial ethical decision making.
PG  - 73-9
LID - 10.1071/AH09543 [doi]
AB  - This paper explores the interplay between individual values, espoused
      organisational values and the values of the organisational culture in practice in
      light of a recent Royal Commission in Queensland, Australia, which highlighted
      systematic failures in patient care. The lack of congruence among values at these
      levels impacts upon the ethical decision making of health managers. The presence 
      of institutional ethics regimes such as the Public Sector Ethics Act 1994 (Qld)
      and agency codes of conduct are not sufficient to counteract the negative
      influence of informal codes of practice that undermine espoused organisational
      values and community standards. The ethical decision-making capacity of health
      care managers remains at the front line in the battle against unethical and
      unprofessional practice.
FAU - Casali, Gian Luca
AU  - Casali GL
AD  - School of Management, Queensland University of Technology, Gardens Point, QLD
      4000, Australia. luca.casali@qut.edu.au
FAU - Day, Gary E
AU  - Day GE
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Aust Health Rev
JT  - Australian health review : a publication of the Australian Hospital Association
JID - 8214381
MH  - *Conflict, Psychological
MH  - Decision Making/*ethics
MH  - *Hospital Administrators
MH  - Humans
MH  - Organizational Case Studies
MH  - *Organizational Culture
MH  - Queensland
EDAT- 2010/03/26 06:00
MHDA- 2010/05/06 06:00
CRDT- 2010/03/26 06:00
PHST- 2007/06/04 00:00 [received]
PHST- 2009/03/23 00:00 [accepted]
PHST- 2010/03/26 06:00 [entrez]
PHST- 2010/03/26 06:00 [pubmed]
PHST- 2010/05/06 06:00 [medline]
AID - AH09543 [pii]
AID - 10.1071/AH09543 [doi]
PST - ppublish
SO  - Aust Health Rev. 2010 Mar;34(1):73-9. doi: 10.1071/AH09543.


PMID- 20334746
OWN - NLM
STAT- MEDLINE
DCOM- 20100504
LR  - 20220410
IS  - 1488-2310 (Electronic)
IS  - 0008-428X (Linking)
VI  - 53
IP  - 2
DP  - 2010 Apr
TI  - Ethical issues in surgical research.
PG  - 133-6
FAU - McDonald, Patrick J
AU  - McDonald PJ
AD  - Section of Neurosurgery, Department of Surgery, University of Manitoba, Winnipeg,
      MB R3A 1R9. PMcDonald@exchange.hsc.mb.ca
FAU - Kulkarni, Abhaya V
AU  - Kulkarni AV
FAU - Farrokhyar, Forough
AU  - Farrokhyar F
FAU - Bhandari, Mohit
AU  - Bhandari M
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can J Surg
JT  - Canadian journal of surgery. Journal canadien de chirurgie
JID - 0372715
RN  - 0 (Placebos)
SB  - IM
MH  - *Biomedical Research
MH  - Conflict of Interest
MH  - Ethics Committees, Research
MH  - *Ethics, Research
MH  - Humans
MH  - Placebos
MH  - Randomized Controlled Trials as Topic
MH  - *Surgical Procedures, Operative
PMC - PMC2845955
EDAT- 2010/03/26 06:00
MHDA- 2010/05/05 06:00
CRDT- 2010/03/26 06:00
PHST- 2010/03/26 06:00 [entrez]
PHST- 2010/03/26 06:00 [pubmed]
PHST- 2010/05/05 06:00 [medline]
PST - ppublish
SO  - Can J Surg. 2010 Apr;53(2):133-6.


PMID- 20333922
OWN - NLM
STAT- MEDLINE
DCOM- 20100416
LR  - 20131121
IS  - 1078-4535 (Print)
IS  - 1078-4535 (Linking)
VI  - 16
IP  - 1
DP  - 2010
TI  - Nursing in the sandbox: a lived experience.
PG  - 29-32
AB  - Despite an extensive career in military nursing, the author's deployment to Iraq 
      included experiences for which no amount of education could have prepared her:
      the extreme living conditions, harrowing battlefield injuries, and ethical
      dilemmas she confronted.
FAU - Haynes-Smith, Glennena
AU  - Haynes-Smith G
AD  - Henry P. Becton School of Nursing and Allied Health at Fairleigh Dickinson
      University, Teaneck, New Jersey, USA. glennena@fdu.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Creat Nurs
JT  - Creative nursing
JID - 9505022
MH  - *Adaptation, Psychological
MH  - *Attitude of Health Personnel
MH  - Curriculum
MH  - Education, Nursing, Continuing/organization & administration
MH  - Faculty, Nursing
MH  - Humans
MH  - Iraq War, 2003-2011
MH  - Military Nursing/education/*organization & administration
MH  - New Jersey
MH  - Nurse's Role/*psychology
MH  - Nursing Staff/education/organization & administration/*psychology
EDAT- 2010/03/26 06:00
MHDA- 2010/04/17 06:00
CRDT- 2010/03/26 06:00
PHST- 2010/03/26 06:00 [entrez]
PHST- 2010/03/26 06:00 [pubmed]
PHST- 2010/04/17 06:00 [medline]
PST - ppublish
SO  - Creat Nurs. 2010;16(1):29-32.


PMID- 20333477
OWN - NLM
STAT- MEDLINE
DCOM- 20110922
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 17
IP  - 1
DP  - 2011 Mar
TI  - What are applied ethics?
PG  - 1-19
LID - 10.1007/s11948-010-9200-z [doi]
AB  - This paper explores the relationships that various applied ethics bear to each
      other, both in particular disciplines and more generally. The introductory
      section lays out the challenge of coming up with such an account and, drawing a
      parallel with the philosophy of science, offers that applied ethics may either be
      unified or disunified. The second section develops one simple account through
      which applied ethics are unified, vis-a-vis ethical theory. However, this is not 
      taken to be a satisfying answer, for reasons explained. In the third section,
      specific applied ethics are explored: biomedical ethics; business ethics;
      environmental ethics; and neuroethics. These are chosen not to be comprehensive, 
      but rather for their traditions or other illustrative purposes. The final section
      draws together the results of the preceding analysis and defends a disunity
      conception of applied ethics.
FAU - Allhoff, Fritz
AU  - Allhoff F
AD  - Department of Philosophy, Western Michigan University, Kalamazoo, MI, USA.
      fritz.allhoff@wmich.edu
LA  - eng
PT  - Journal Article
DEP - 20100324
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Conservation of Natural Resources
MH  - *Ethical Theory
MH  - *Ethics, Business
MH  - *Ethics, Medical
MH  - Science/*ethics
EDAT- 2010/03/25 06:00
MHDA- 2011/09/23 06:00
CRDT- 2010/03/25 06:00
PHST- 2009/11/03 00:00 [received]
PHST- 2010/02/18 00:00 [accepted]
PHST- 2010/03/25 06:00 [entrez]
PHST- 2010/03/25 06:00 [pubmed]
PHST- 2011/09/23 06:00 [medline]
AID - 10.1007/s11948-010-9200-z [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2011 Mar;17(1):1-19. doi: 10.1007/s11948-010-9200-z. Epub 2010
      Mar 24.


PMID- 20333473
OWN - NLM
STAT- MEDLINE
DCOM- 20100617
LR  - 20211020
IS  - 1573-0980 (Electronic)
IS  - 1386-7415 (Linking)
VI  - 31
IP  - 2
DP  - 2010 Apr
TI  - The epistemology and ethics of chronic disease research: further lessons from
      ECMO.
PG  - 107-22
LID - 10.1007/s11017-010-9139-8 [doi]
AB  - Robert Truog describes the controversial randomized controlled trials (RCTs) of
      extracorporeal membrane oxygenation (ECMO) therapy in newborns. Because early
      results with ECMO indicated that it might be a great advance, saving many lives, 
      Truog argues that ECMO should not have been tested using RCTs, but that a
      long-term, large-scale observational study of actual clinical practice should
      have been conducted instead. Central to Truog's argument, however, is the idea
      that ECMO is an unusual case. Thus, it is an open question whether Truog's
      conclusions can be extended to other areas of medical research. In this paper, I 
      look at epistemological and ethical issues arising in the care of patients with
      chronic diseases, using ECMO as a starting point. Both the similarities and the
      dissimilarities of these two cases highlight important issues in biomedical
      research and support a conclusion similar to Truog's. Observational studies of
      clinical practice provide the best evidence to inform the treatment of patients
      with chronic disease.
FAU - Bluhm, Robyn
AU  - Bluhm R
AD  - Department of Philosophy and Religious Studies, Old Dominion University, Norfolk,
      VA 23529, USA. rbluhm@odu.edu
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Theor Med Bioeth
JT  - Theoretical medicine and bioethics
JID - 9805378
SB  - IM
MH  - Bioethical Issues
MH  - *Chronic Disease
MH  - *Ethics, Research
MH  - Evidence-Based Medicine
MH  - Extracorporeal Membrane Oxygenation/*ethics
MH  - Humans
MH  - Infant, Newborn
MH  - *Knowledge
MH  - Observation
MH  - Patient Selection
MH  - Randomized Controlled Trials as Topic/ethics
MH  - Reproducibility of Results
MH  - Research Design
MH  - Selection Bias
MH  - Treatment Outcome
EDAT- 2010/03/25 06:00
MHDA- 2010/06/18 06:00
CRDT- 2010/03/25 06:00
PHST- 2010/03/25 06:00 [entrez]
PHST- 2010/03/25 06:00 [pubmed]
PHST- 2010/06/18 06:00 [medline]
AID - 10.1007/s11017-010-9139-8 [doi]
PST - ppublish
SO  - Theor Med Bioeth. 2010 Apr;31(2):107-22. doi: 10.1007/s11017-010-9139-8.


PMID- 20332813
OWN - NLM
STAT- MEDLINE
DCOM- 20100916
LR  - 20211020
IS  - 1476-5438 (Electronic)
IS  - 1018-4813 (Linking)
VI  - 18
IP  - 7
DP  - 2010 Jul
TI  - Retrospective access to data: the ENGAGE consent experience.
PG  - 741-5
LID - 10.1038/ejhg.2010.30 [doi]
AB  - The rapid emergence of large-scale genetic databases raises issues at the nexus
      of medical law and ethics, as well as the need, at both national and
      international levels, for an appropriate and effective framework for their
      governance. This is even more so for retrospective access to data for secondary
      uses, wherein the original consent did not foresee such use. The first part of
      this paper provides a brief historical overview of the ethical and legal
      frameworks governing consent issues in biobanking generally, before turning to
      the secondary use of retrospective data in epidemiological biobanks. Such use
      raises particularly complex issues when (1) the original consent provided is
      restricted; (2) the minor research subject reaches legal age; (3) the research
      subject dies; or (4) samples and data were obtained during medical care. Our
      analysis demonstrates the inconclusive, and even contradictory, nature of
      guidelines and confirms the current lack of compatible regulations. The second
      part of this paper uses the European Network for Genetic and Genomic Epidemiology
      (ENGAGE Consortium) as a case study to illustrate the challenges of research
      using previously collected data sets in Europe. Our study of 52 ENGAGE consent
      forms and information documents shows that a broad range of mechanisms were
      developed to enable secondary use of the data that are part of the ENGAGE
      Consortium.
FAU - Tasse, Anne Marie
AU  - Tasse AM
AD  - Universite de Montreal, Faculte de droit, Montreal, Canada.
      anne-marie.tasse@umontreal.ca
FAU - Budin-Ljosne, Isabelle
AU  - Budin-Ljosne I
FAU - Knoppers, Bartha Maria
AU  - Knoppers BM
FAU - Harris, Jennifer R
AU  - Harris JR
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100324
PL  - England
TA  - Eur J Hum Genet
JT  - European journal of human genetics : EJHG
JID - 9302235
SB  - IM
MH  - Access to Information/*ethics/history/*legislation & jurisprudence
MH  - *Databases, Genetic
MH  - Europe
MH  - *Genetic Research/ethics/legislation & jurisprudence
MH  - History, 20th Century
MH  - Humans
MH  - Informed Consent/*ethics/history/*legislation & jurisprudence
MH  - *International Cooperation
MH  - Public Policy
MH  - *Retrospective Studies
MH  - Tissue Banks/ethics/history/legislation & jurisprudence
PMC - PMC2987368
EDAT- 2010/03/25 06:00
MHDA- 2010/09/18 06:00
CRDT- 2010/03/25 06:00
PHST- 2010/03/25 06:00 [entrez]
PHST- 2010/03/25 06:00 [pubmed]
PHST- 2010/09/18 06:00 [medline]
AID - ejhg201030 [pii]
AID - 10.1038/ejhg.2010.30 [doi]
PST - ppublish
SO  - Eur J Hum Genet. 2010 Jul;18(7):741-5. doi: 10.1038/ejhg.2010.30. Epub 2010 Mar
      24.


PMID- 20332272
OWN - NLM
STAT- MEDLINE
DCOM- 20100709
LR  - 20211028
IS  - 1538-7755 (Electronic)
IS  - 1055-9965 (Linking)
VI  - 19
IP  - 4
DP  - 2010 Apr
TI  - Custodianship as an ethical framework for biospecimen-based research.
PG  - 1012-5
LID - 10.1158/1055-9965.EPI-10-0029 [doi]
AB  - Human biological specimens (biospecimens) are increasingly important for research
      that aims to advance human health. Yet, despite significant proliferation in
      specimen-based research and discoveries during the past decade, research remains 
      challenged by the inequitable access to high-quality biospecimens that are
      collected under rigorous ethical standards. This is primarily caused by the
      complex level of control and ownership exerted by the myriad of stakeholders
      involved in the biospecimen research process. This article discusses the ethical 
      model of custodianship as a framework for biospecimen-based research to promote
      fair research access and resolve issues of control and potential conflicts
      between biobanks, investigators, human research participants (human subjects),
      and sponsors. Custodianship is the caretaking obligation for biospecimens from
      initial collection to final dissemination of research findings. It endorses key
      practices and operating principles for responsible oversight of biospecimens
      collected for research. Embracing the custodial model would ensure transparency
      in research, fairness to human research participants, and shared accountability
      among all stakeholders involved in biospecimen-based research.
FAU - Yassin, Rihab
AU  - Yassin R
AD  - Division of Cancer Biology, National Cancer Institute, 6130 Executive Boulevard, 
      Suite 5000, Bethesda, MD 20892, USA. ry38k@NIH.gov
FAU - Lockhart, Nicole
AU  - Lockhart N
FAU - Gonzalez del Riego, Mariana
AU  - Gonzalez del Riego M
FAU - Pitt, Karen
AU  - Pitt K
FAU - Thomas, Jeffrey W
AU  - Thomas JW
FAU - Weiss, Linda
AU  - Weiss L
FAU - Compton, Carolyn
AU  - Compton C
LA  - eng
GR  - Z99 CA999999/ImNIH/Intramural NIH HHS/United States
GR  - HHSN261200800001E/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20100323
PL  - United States
TA  - Cancer Epidemiol Biomarkers Prev
JT  - Cancer epidemiology, biomarkers & prevention : a publication of the American
      Association for Cancer Research, cosponsored by the American Society of
      Preventive Oncology
JID - 9200608
SB  - IM
MH  - Biological Specimen Banks/*ethics/standards
MH  - Biomedical Research/*ethics/methods
MH  - Humans
MH  - Specimen Handling/*ethics/standards
RF  - 19
PMC - PMC2858050
MID - NIHMS182851
EDAT- 2010/03/25 06:00
MHDA- 2010/07/10 06:00
CRDT- 2010/03/25 06:00
PHST- 2010/03/25 06:00 [entrez]
PHST- 2010/03/25 06:00 [pubmed]
PHST- 2010/07/10 06:00 [medline]
AID - 1055-9965.EPI-10-0029 [pii]
AID - 10.1158/1055-9965.EPI-10-0029 [doi]
PST - ppublish
SO  - Cancer Epidemiol Biomarkers Prev. 2010 Apr;19(4):1012-5. doi:
      10.1158/1055-9965.EPI-10-0029. Epub 2010 Mar 23.


PMID- 20332270
OWN - NLM
STAT- MEDLINE
DCOM- 20100709
LR  - 20211203
IS  - 1538-7755 (Electronic)
IS  - 1055-9965 (Linking)
VI  - 19
IP  - 4
DP  - 2010 Apr
TI  - The Organization of European Cancer Institute Pathobiology Working Group and its 
      support of European biobanking infrastructures for translational cancer research.
PG  - 923-6
LID - 10.1158/1055-9965.EPI-10-0062 [doi]
AB  - BACKGROUND: Today's translational cancer research increasingly depends on
      international multi-center studies. Biobanking infrastructure or comprehensive
      sample exchange platforms to enable networking of clinical cancer biobanks are
      instrumental to facilitate communication, uniform sample quality, and rules for
      exchange. METHODS: The Organization of European Cancer Institutes (OECI)
      Pathobiology Working Group supports European biobanking infrastructure by
      maintaining the OECI-TuBaFrost exchange platform and organizing regular meetings.
      This platform originated from a European Commission project and is updated with
      knowledge from ongoing and new biobanking projects. This overview describes how
      European biobanking projects that have a large impact on clinical biobanking,
      including EuroBoNeT, SPIDIA, and BBMRI, contribute to the update of the
      OECI-TuBaFrost exchange platform. RESULTS: Combining the results of these
      European projects enabled the creation of an open (upon valid registration only) 
      catalogue view of cancer biobanks and their available samples to initiate
      research projects. In addition, closed environments supporting active projects
      could be developed together with the latest views on quality, access rules,
      ethics, and law. CONCLUSIONS: With these contributions, the OECI Pathobiology
      Working Group contributes to and stimulates a professional attitude within
      biobanks at the European comprehensive cancer centers. IMPACT: Improving the
      fundamentals of cancer sample exchange in Europe stimulates the performance of
      large multi-center studies, resulting in experiments with the desired statistical
      significance outcome. With this approach, future innovation in cancer patient
      care can be realized faster and more reliably.
FAU - Riegman, Peter H J
AU  - Riegman PH
AD  - Department of Pathology, Josephine Nefkens Institute, Be 235b, Erasmus Medical
      Center, P.O. Box 2040, 3000CA Rotterdam, The Netherlands. p.riegman@erasmusmc.nl
FAU - de Jong, Bas W D
AU  - de Jong BW
FAU - Llombart-Bosch, Antonio
AU  - Llombart-Bosch A
LA  - eng
PT  - Journal Article
DEP - 20100323
PL  - United States
TA  - Cancer Epidemiol Biomarkers Prev
JT  - Cancer epidemiology, biomarkers & prevention : a publication of the American
      Association for Cancer Research, cosponsored by the American Society of
      Preventive Oncology
JID - 9200608
SB  - IM
MH  - Academies and Institutes/organization & administration
MH  - Europe
MH  - Humans
MH  - Multicenter Studies as Topic
MH  - *Neoplasms
MH  - Pathology, Clinical/methods/organization & administration/standards
MH  - Specimen Handling/methods/standards
MH  - Tissue Banks/*organization & administration/standards
MH  - Translational Research, Biomedical/methods/*organization &
      administration/standards
EDAT- 2010/03/25 06:00
MHDA- 2010/07/10 06:00
CRDT- 2010/03/25 06:00
PHST- 2010/03/25 06:00 [entrez]
PHST- 2010/03/25 06:00 [pubmed]
PHST- 2010/07/10 06:00 [medline]
AID - 1055-9965.EPI-10-0062 [pii]
AID - 10.1158/1055-9965.EPI-10-0062 [doi]
PST - ppublish
SO  - Cancer Epidemiol Biomarkers Prev. 2010 Apr;19(4):923-6. doi:
      10.1158/1055-9965.EPI-10-0062. Epub 2010 Mar 23.


PMID- 20331891
OWN - NLM
STAT- MEDLINE
DCOM- 20100521
LR  - 20220408
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 11
DP  - 2010 Mar 23
TI  - Handling ethical, legal and social issues in birth cohort studies involving
      genetic research: responses from studies in six countries.
PG  - 4
LID - 10.1186/1472-6939-11-4 [doi]
AB  - BACKGROUND: Research involving minors has been the subject of much ethical
      debate. The growing number of longitudinal, pediatric studies that involve
      genetic research present even more complex challenges to ensure appropriate
      protection of children and families as research participants. Long-term studies
      with a genetic component involve collection, retention and use of biological
      samples and personal information over many years. Cohort studies may be
      established to study specific conditions (e.g. autism, asthma) or may have a
      broad aim to research a range of factors that influence the health and
      development of children. Studies are increasingly intended to serve as research
      platforms by providing access to data and biological samples to researchers over 
      many years.This study examines how six birth cohort studies in North America and 
      Europe that involve genetic research handle key ethical, legal and social (ELS)
      issues: recruitment, especially parental authority to include a child in
      research; initial parental consent and subsequent assent and/or consent from the 
      maturing child; withdrawal; confidentiality and sample/data protection; handling 
      sensitive information; and disclosure of results. METHODS: Semi-structured
      telephone interviews were carried out in 2008/09 with investigators involved in
      six birth cohort studies in Canada, Denmark, England, France, the Netherlands and
      the United States. Interviewees self-identified as being knowledgeable about ELS 
      aspects of the study. Interviews were conducted in English. RESULTS: The studies 
      vary in breadth of initial consent, but none adopt a blanket consent for future
      use of samples/data. Ethics review of new studies is a common requirement.
      Studies that follow children past early childhood recognise a need to seek
      assent/consent as the child matures. All studies limit access to identifiable
      data and advise participants of the right to withdraw. The clearest differences
      among studies concern handling of sensitive information and return of results. In
      all studies, signs of child abuse require reports to authorities, but this
      disclosure duty is not always stated in consent materials. Studies vary in
      whether they will return to participants results of routine tests/measures, but
      none inform participants about findings with unknown clinical significance.
      CONCLUSIONS: Analysis of how cohort studies in various jurisdictions handle key
      ELS issues provides informative data for comparison and contrast. Consideration
      of these and other examples and further scholarly exploration of ELS issues
      provides insight on how best to address these aspects in ways that respect the
      well-being of participants, especially children who become research subjects at
      the start of their lives.
FAU - Ries, Nola M
AU  - Ries NM
AD  - Health Law Institute, Law Centre, University of Alberta, Edmonton, T6G 2H5,
      Canada.
FAU - LeGrandeur, Jane
AU  - LeGrandeur J
FAU - Caulfield, Timothy
AU  - Caulfield T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100323
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Adolescent
MH  - Canada
MH  - Child
MH  - Child Abuse
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Confidentiality
MH  - Ethics, Research
MH  - Europe
MH  - Genetic Research/*ethics/*legislation & jurisprudence
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - *Informed Consent/ethics/legislation & jurisprudence
MH  - Mandatory Reporting/ethics
MH  - *Minors
MH  - Parental Consent/ethics/legislation & jurisprudence
MH  - *Research Subjects/economics/legislation & jurisprudence
MH  - *Social Environment
MH  - Surveys and Questionnaires
MH  - Telephone
MH  - *Tissue Banks/ethics/legislation & jurisprudence
MH  - Truth Disclosure/ethics
MH  - United States
RF  - 35
PMC - PMC2859353
EDAT- 2010/03/25 06:00
MHDA- 2010/05/22 06:00
CRDT- 2010/03/25 06:00
PHST- 2009/11/13 00:00 [received]
PHST- 2010/03/23 00:00 [accepted]
PHST- 2010/03/25 06:00 [entrez]
PHST- 2010/03/25 06:00 [pubmed]
PHST- 2010/05/22 06:00 [medline]
AID - 1472-6939-11-4 [pii]
AID - 10.1186/1472-6939-11-4 [doi]
PST - epublish
SO  - BMC Med Ethics. 2010 Mar 23;11:4. doi: 10.1186/1472-6939-11-4.


PMID- 20329654
OWN - NLM
STAT- MEDLINE
DCOM- 20100423
LR  - 20211203
IS  - 0004-4172 (Print)
IS  - 0004-4172 (Linking)
VI  - 60
IP  - 2
DP  - 2010
TI  - Effects of a low-dose antihypertensive diuretic in combination with losartan,
      telmisartan, or candesartan on serum urate levels in hypertensive patients.
PG  - 71-5
LID - 10.1055/s-0031-1296251 [doi]
AB  - BACKGROUND: A combination therapy of a low-dose antihypertensive diuretic with an
      angiotensin II receptor blocker (ARB) may have unfavorable effects on serum urate
      levels. METHODS: Forty-two hypertensive patients without hyperuricemia (18 men
      and 24 women, mean age 65 years) were randomly divided into three groups. Each of
      the group was allocated to a combination therapy with losartan (LOS; CAS
      124750-99-8; 50 mg/day)/hydrochlorothiazide (HCTZ; CAS 58-93-5; 12.5 mg/day)
      (LOS/HCTZ group), telmisartan (TEL; CAS 144701-48-4; 40 mg/day)/HCTZ (12.5
      mg/day) (TEL/HCTZ group), or candesartan (CND; CAS 145040-37-5; 8 mg/day)/HCTZ
      (12.5 mg/day) (CND/HCTZ group), respectively. Before and after the treatment,
      blood pressure and biochemical parameters of blood and urine were evaluated.
      RESULTS: Both systolic and diastolic blood pressures significantly decreased in
      all groups (p < 0.01) without any statistical differences. The LOS/HCTZ group
      showed no changes in serum urate levels (5.8 +/- 1.0 mg/dl to 5.8 +/- 1.4 mg/dl) 
      and in % fractional excretion of urate (FEUA). In the TEL/HCTZ group, the serum
      urate level was significantly increased, from 5.5 +/- 0.9 mg/dl to 6.5 +/- 1.2
      mg/dl (p < 0.01), whereas FEUA significantly decreased (p < 0.01). Similarly, the
      CND/HCTZ group showed a significant increase in the serum urate level from 5.4
      +/- 0.9 mg/dl to 6.0 +/- 1.2 mg/dl (p < 0.01) and a significant decrease in FEUA 
      (p < 0.01). No significant differences were found in fasting plasma glucose and
      electrolytes levels in any of the groups. CONCLUSIONS: A combination therapy with
      a low-dose HCTZ and ARBs resulted in reduced urate excretion and elevated serum
      urate levels. A combination therapy with the ARB losartan was not accompanied
      with these effects, likely because of its inhibitory action on urate transporter 
      1. The study limitations deserve mention in consideration of ethic restrictions, 
      small size, short term examination and uncontrolled design.
FAU - Hamada, Toshihiro
AU  - Hamada T
AD  - Department of Cardiovascular Medicine, Faculty of Medicine, Tottori University,
      Yonago, Japan. thammer@chukai.ne.jp
FAU - Mizuta, Einosuke
AU  - Mizuta E
FAU - Kondo, Takehito
AU  - Kondo T
FAU - Hirai, Masayuki
AU  - Hirai M
FAU - Yamada, Kensaku
AU  - Yamada K
FAU - Kato, Masahiko
AU  - Kato M
FAU - Shigemasa, Chiaki
AU  - Shigemasa C
FAU - Yamamoto, Yasutaka
AU  - Yamamoto Y
FAU - Ninomiya, Haruaki
AU  - Ninomiya H
FAU - Igawa, Osamu
AU  - Igawa O
FAU - Hisatome, Ichiro
AU  - Hisatome I
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Germany
TA  - Arzneimittelforschung
JT  - Arzneimittel-Forschung
JID - 0372660
RN  - 0 (Angiotensin II Type 1 Receptor Blockers)
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Benzimidazoles)
RN  - 0 (Benzoates)
RN  - 0 (Biphenyl Compounds)
RN  - 0 (Blood Glucose)
RN  - 0 (Diuretics)
RN  - 0 (Lipids)
RN  - 0 (Tetrazoles)
RN  - 268B43MJ25 (Uric Acid)
RN  - JMS50MPO89 (Losartan)
RN  - S8Q36MD2XX (candesartan)
RN  - U5SYW473RQ (Telmisartan)
SB  - IM
MH  - Aged
MH  - Angiotensin II Type 1 Receptor Blockers/*therapeutic use
MH  - Antihypertensive Agents/*therapeutic use
MH  - Benzimidazoles/*therapeutic use
MH  - Benzoates/*therapeutic use
MH  - Biphenyl Compounds
MH  - Blood Glucose/metabolism
MH  - Diuretics/*therapeutic use
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Hypertension/*blood/*drug therapy
MH  - Lipids/blood
MH  - Losartan/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Telmisartan
MH  - Tetrazoles/*therapeutic use
MH  - Uric Acid/*blood
EDAT- 2010/03/25 06:00
MHDA- 2010/04/24 06:00
CRDT- 2010/03/25 06:00
PHST- 2010/03/25 06:00 [entrez]
PHST- 2010/03/25 06:00 [pubmed]
PHST- 2010/04/24 06:00 [medline]
AID - 10.1055/s-0031-1296251 [doi]
PST - ppublish
SO  - Arzneimittelforschung. 2010;60(2):71-5. doi: 10.1055/s-0031-1296251.


PMID- 20329461
OWN - NLM
STAT- MEDLINE
DCOM- 20100504
LR  - 20100324
IS  - 1320-159X (Print)
IS  - 1320-159X (Linking)
VI  - 17
IP  - 4
DP  - 2010 Feb
TI  - Queensland's proposed surrogacy legislation: an opportunity for national reform.
PG  - 617-32
AB  - Surrogacy has existed since Biblical times when Hagar, the maidservant of the
      infertile Sarah, acted as a surrogate to bear Sarah and her husband, Abraham, a
      son. Despite the longevity of the practice of surrogacy, modern society has been 
      reluctant to embrace surrogacy arrangements due to the ethical and sometimes
      practical debates they spark. This reluctance is evidenced by the general lack of
      legislative support for surrogacy arrangements in Australia and worldwide. In
      2009 it was announced that Queensland will decriminalise altruistic surrogacy.
      While this decision is a step towards bringing Queensland in line with other
      Australian jurisdictions, it also has the potential to open up a Pandora's Box of
      legal and ethical issues. This article provides a snapshot of the anticipated new
      Queensland surrogacy legislation together with a brief overview of the regulation
      of surrogacy in all Australian jurisdictions. Recommendations are made as to
      whether there is a need for further reform of surrogacy regulation in certain
      Australian jurisdictions and if so, whether the proposed Queensland legislation
      constitutes an appropriate model on which to base such reform.
FAU - Johnson, Tammy
AU  - Johnson T
AD  - Faculty of Law, Queensland University of Technology, Brisbane.
      tjohnson@bond.edu.au
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Law Med
JT  - Journal of law and medicine
JID - 9431853
SB  - IM
MH  - Australia
MH  - Female
MH  - Humans
MH  - Pregnancy
MH  - Surrogate Mothers/*legislation & jurisprudence
EDAT- 2010/03/25 06:00
MHDA- 2010/05/05 06:00
CRDT- 2010/03/25 06:00
PHST- 2010/03/25 06:00 [entrez]
PHST- 2010/03/25 06:00 [pubmed]
PHST- 2010/05/05 06:00 [medline]
PST - ppublish
SO  - J Law Med. 2010 Feb;17(4):617-32.


PMID- 20329460
OWN - NLM
STAT- MEDLINE
DCOM- 20100504
LR  - 20100324
IS  - 1320-159X (Print)
IS  - 1320-159X (Linking)
VI  - 17
IP  - 4
DP  - 2010 Feb
TI  - Prospective application of a five-step regulatory assessment model to a proposed 
      federal sperm donor registry in Australia: is it in the public interest?
PG  - 608-16
AB  - It has been proposed that a nationally mandated donor registry be established in 
      Australia to provide data for estimating the possible number of inadvertent
      half-sibling matings resulting from the multiple use of anonymous donors in donor
      insemination and to assist identity-release donors and their donor-inseminated
      children to establish contact. A five-step regulatory assessment model, as
      described by Johnson and Petersen in 2008, was applied prospectively to the
      proposed donor registry to identify public interest issues. The resultant issues 
      concern the public ethical interest in child welfare; the public health interest 
      in avoiding genetic abnormalities/disease; public socio-political and legal
      interests in avoiding inadvertent consanguineous relationships; public ethical
      and health interests in avoiding identity issues in the donor-inseminated child; 
      and public socio-ethical interests in providing nationally mandated,
      comprehensive records of donor insemination outcomes. These results provide a
      basis for further discussion in regard to donor insemination legislation at the
      federal level.
FAU - Sawyer, Neroli
AU  - Sawyer N
AD  - School of Behavioural and Social Sciences and Humanities, University of Ballarat,
      Mount Helen, Vic 3352, Australia. n.sawyer@ballarat.edu.au
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Law Med
JT  - Journal of law and medicine
JID - 9431853
SB  - IM
MH  - Australia
MH  - Humans
MH  - Male
MH  - *Registries
MH  - Reproductive Techniques, Assisted/legislation & jurisprudence
MH  - *Spermatozoa
MH  - Tissue Donors/*legislation & jurisprudence
EDAT- 2010/03/25 06:00
MHDA- 2010/05/05 06:00
CRDT- 2010/03/25 06:00
PHST- 2010/03/25 06:00 [entrez]
PHST- 2010/03/25 06:00 [pubmed]
PHST- 2010/05/05 06:00 [medline]
PST - ppublish
SO  - J Law Med. 2010 Feb;17(4):608-16.


PMID- 20329459
OWN - NLM
STAT- MEDLINE
DCOM- 20100504
LR  - 20181201
IS  - 1320-159X (Print)
IS  - 1320-159X (Linking)
VI  - 17
IP  - 4
DP  - 2010 Feb
TI  - Separating conjoined twins: a medical and criminal law dilemma.
PG  - 594-607
AB  - Surgical separation of conjoined twins that results in the death of one of the
      twins raises complex moral, ethical and legal issues. Of particular concern is
      the potential for homicide charges against doctors. In two recent cases, one in
      England and one in Queensland, judges declared the surgery to be lawful but the
      legal reasoning employed is problematical and may be difficult to apply to future
      conjoined twins cases, such as infant twins where one is not fully developed, or 
      where it is proposed to separate adult twins. A determination of the threshold
      issue of whether there are two individual persons capable of being killed may
      require a reconsideration of existing legal definitions and statutory provisions.
      Similarly, the excuses and justifications for homicide may need to be clarified
      or reviewed in the context of separation of conjoined twins.
FAU - Davis, Colleen
AU  - Davis C
AD  - School of Law, Griffith University. Colleen.Davis@griffith.edu.au
LA  - eng
PT  - Journal Article
PT  - Legal Case
PL  - Australia
TA  - J Law Med
JT  - Journal of law and medicine
JID - 9431853
SB  - IM
MH  - Australia
MH  - Criminal Law
MH  - England
MH  - Humans
MH  - Surgical Procedures, Operative/*ethics/*legislation & jurisprudence
MH  - Twins, Conjoined/*surgery
EDAT- 2010/03/25 06:00
MHDA- 2010/05/05 06:00
CRDT- 2010/03/25 06:00
PHST- 2010/03/25 06:00 [entrez]
PHST- 2010/03/25 06:00 [pubmed]
PHST- 2010/05/05 06:00 [medline]
PST - ppublish
SO  - J Law Med. 2010 Feb;17(4):594-607.


PMID- 20309961
OWN - NLM
STAT- MEDLINE
DCOM- 20100618
LR  - 20211020
IS  - 1549-4918 (Electronic)
IS  - 1066-5099 (Linking)
VI  - 28
IP  - 4
DP  - 2010 Apr
TI  - Law, ethics, religion, and clinical translation in the 21st century--A discussion
      with Pete Coffey.
PG  - 636-8
LID - 10.1002/stem.414 [doi]
FAU - Coffey, Pete
AU  - Coffey P
LA  - eng
GR  - G1000730/MRC_/Medical Research Council/United Kingdom
PT  - Interview
PL  - England
TA  - Stem Cells
JT  - Stem cells (Dayton, Ohio)
JID - 9304532
SB  - IM
MH  - *Bioethical Issues
MH  - Humans
MH  - *Legislation as Topic
MH  - *Religion
MH  - Research Design/legislation & jurisprudence
MH  - Stem Cell Transplantation
MH  - *Stem Cells
PMC - PMC2962906
EDAT- 2010/03/24 06:00
MHDA- 2010/06/19 06:00
CRDT- 2010/03/24 06:00
PHST- 2010/03/24 06:00 [entrez]
PHST- 2010/03/24 06:00 [pubmed]
PHST- 2010/06/19 06:00 [medline]
AID - 10.1002/stem.414 [doi]
PST - ppublish
SO  - Stem Cells. 2010 Apr;28(4):636-8. doi: 10.1002/stem.414.


PMID- 20309383
OWN - NLM
STAT- MEDLINE
DCOM- 20100701
LR  - 20151119
IS  - 2150-1149 (Electronic)
IS  - 1533-3159 (Linking)
VI  - 13
IP  - 2
DP  - 2010 Mar-Apr
TI  - Importance of urine drug testing in the treatment of chronic noncancer pain:
      implications of recent medicare policy changes in kentucky.
PG  - 167-86
AB  - BACKGROUND: Urine drug testing has become a widely used tool in American society 
      for deterring illicit drug use. In the practice of medicine, urine drug testing
      is commonly used to help diagnose substance misuse, abuse, or addiction.
      OBJECTIVE: This narrative review provides an informed perspective on the
      importance of urine drug testing in the medical treatment of chronic noncancer
      pain. The history and current uses of urine drug tests in the United States are
      reviewed, the prevalence and nature of prescription drug misuse is described as
      is related to chronic noncancer pain, and implications and considerations for
      practitioners are presented related to the noncancer pain diagnosis and
      treatment. DISCUSSION: Practitioners are confronted with the ethical and legal
      dilemma of being called to adequately treat chronic pain in a culture with a high
      prevalence of prescription drug abuse. Yet the symptoms of drug abuse are
      nonspecific and therefore of limited value to the practitioner in determining
      patient compliance to drug treatment regimens. In contrast, urine drug testing
      has a reliable history, both in and out of medicine, as an independent sign of
      drug misuse. This sign can be used to aid in the diagnosis and treatment of drug 
      misuse and underlying addictions to improve patient outcomes. CONCLUSION: Regular
      urine drug testing should be a part of acute and chronic pain management whether 
      or not the patient has any signs or symptoms of drug misuse.
FAU - Gilbert, John W
AU  - Gilbert JW
AD  - Spine and Brain Neurosurgical Center, Lexington, KY, USA.
FAU - Wheeler, G R
AU  - Wheeler GR
FAU - Mick, G E
AU  - Mick GE
FAU - Storey, B B
AU  - Storey BB
FAU - Herder, S L
AU  - Herder SL
FAU - Richardson, G B
AU  - Richardson GB
FAU - Watts, E
AU  - Watts E
FAU - Gyarteng-Dakwa, K
AU  - Gyarteng-Dakwa K
FAU - Marino, B S
AU  - Marino BS
FAU - Kenney, C M
AU  - Kenney CM
FAU - Siddiqi, M
AU  - Siddiqi M
FAU - Broughton, P G
AU  - Broughton PG
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Pain Physician
JT  - Pain physician
JID - 100954394
SB  - IM
MH  - History, 20th Century
MH  - Humans
MH  - Kentucky
MH  - Legislation, Drug/*trends
MH  - Medicare/*trends
MH  - Opioid-Related Disorders/*diagnosis/prevention & control/*urine
MH  - Pain, Intractable/*drug therapy/prevention & control
MH  - Practice Patterns, Physicians'/legislation & jurisprudence/standards/trends
MH  - Prescriptions/standards
MH  - Substance Abuse Detection/history/legislation & jurisprudence/*standards
MH  - United States
MH  - Urinalysis/history/*standards
RF  - 208
EDAT- 2010/03/24 06:00
MHDA- 2010/07/02 06:00
CRDT- 2010/03/24 06:00
PHST- 2010/03/24 06:00 [entrez]
PHST- 2010/03/24 06:00 [pubmed]
PHST- 2010/07/02 06:00 [medline]
PST - ppublish
SO  - Pain Physician. 2010 Mar-Apr;13(2):167-86.


PMID- 20309377
OWN - NLM
STAT- MEDLINE
DCOM- 20100701
LR  - 20151119
IS  - 2150-1149 (Electronic)
IS  - 1533-3159 (Linking)
VI  - 13
IP  - 2
DP  - 2010 Mar-Apr
TI  - A perfect storm in interventional pain management: regulated, but unbalanced.
PG  - 109-16
AB  - Interventional pain management now stands at the crossroads at what is described 
      as "the perfect storm." The confluence of several factors has led to devastating 
      results for interventional pain management. This article seeks to provide a
      perspective to various issues producing conditions conducive to creating a
      "perfect storm" such as use and abuse of interventional pain management
      techniques, and in the same context, use and abuse of various non-interventional 
      techniques. The rapid increase in opioid drug prescribing, costs to health care, 
      large increases in death rates, and random and rampant drug testing, can also
      lead to increases in health care utilization. Other important aspects that are
      seldom discussed include medico-legal and ethical perspectives of individual and 
      professional societal opinions and the interpretation of diagnostic accuracy of
      controlled diagnostic blocks. The aim of this article is to discuss the impact of
      several factors on interventional pain management and overuse, abuse, waste, and 
      fraud; inappropriate application without evidence-based literature support
      (sometimes leading to selective use or non-use of randomized or observational
      studies for proving biased viewpoints - post priori rather than a priori), and
      issues related to multiple professional societies having their own agendas to
      push rather than promulgating the science of interventional pain management. This
      perspective is based on a review of articles published in this issue of Pain
      Physician, information in the public domain, and other relevant articles. Based
      on the results of this review, various issues of relevance to modern
      interventional pain management are discussed and the viewpoints of several
      experts debated. In conclusion, supporters of interventional pain management
      disagree on multiple aspects for various reasons while detractors claim that
      interventional pain management should not exist as a speciality. Issues to be
      addressed include appropriate use of evidence-based medicine (EBM), overuse,
      overutilization, and abuse.
FAU - Benyamin, Ramsin M
AU  - Benyamin RM
AD  - Millennium Pain Center, Bloomington, IL 61701, USA. ramsinbenyamin@yahoo.com
FAU - Datta, Sukdeb
AU  - Datta S
FAU - Falco, Frank J E
AU  - Falco FJ
LA  - eng
PT  - Introductory Journal Article
PL  - United States
TA  - Pain Physician
JT  - Pain physician
JID - 100954394
RN  - 0 (Analgesics, Opioid)
SB  - IM
MH  - Analgesia/*ethics/*methods
MH  - Analgesics, Opioid/*administration & dosage/adverse effects
MH  - Drug and Narcotic Control/trends
MH  - Health Care Costs/statistics & numerical data/trends
MH  - Health Services Misuse/statistics & numerical data/trends
MH  - Malpractice/trends
MH  - Neurology/ethics/methods/trends
MH  - Opioid-Related Disorders/epidemiology/prevention & control
MH  - Pain/*drug therapy
MH  - Pain Clinics/*ethics/legislation & jurisprudence/*trends
MH  - Practice Patterns, Physicians'/statistics & numerical data/trends
MH  - Reimbursement Mechanisms/trends
MH  - Substance Abuse Detection/trends
EDAT- 2010/03/24 06:00
MHDA- 2010/07/02 06:00
CRDT- 2010/03/24 06:00
PHST- 2010/03/24 06:00 [entrez]
PHST- 2010/03/24 06:00 [pubmed]
PHST- 2010/07/02 06:00 [medline]
PST - ppublish
SO  - Pain Physician. 2010 Mar-Apr;13(2):109-16.


PMID- 20308459
OWN - NLM
STAT- MEDLINE
DCOM- 20100506
LR  - 20220310
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 255
IP  - 1
DP  - 2010 Apr
TI  - Hyperpolarized 3He MR for sensitive imaging of ventilation function and treatment
      efficiency in young cystic fibrosis patients with normal lung function.
PG  - 225-32
LID - 10.1148/radiol.09090039 [doi]
AB  - PURPOSE: To assess the sensitivity of hyperpolarized helium 3 ((3)He) magnetic
      resonance (MR) imaging for the detection of peripheral airway obstruction in
      younger cystic fibrosis (CF) patients showing normal spirometric results (mean
      forced expiratory volume in 1 second [FEV(1)], 112% +/- 14.5 [standard
      deviation]) and to observe the immediate effects of a single chest physical
      therapy (CPT) session, thereby comparing two image quantification techniques.
      MATERIALS AND METHODS: Ten pediatric CF patients (age range, 8-16 years) with
      normal spirometric results were included in this study after approval from the
      local research ethics committee. Spirometry followed by proton and hyperpolarized
      (3)He three-dimensional lung imaging were performed with a 1.5-T MR unit before
      and after 20 minutes of CPT. The number of ventilation defects per image (VDI)
      and the ventilated lung fraction (VF), defined as the ratio of ventilated lung
      volume divided by total lung volume, were quantified. RESULTS: Ventilation
      defects were found in all patients (mean VDI, 5.1 +/- 1.9; mean global VF, 78.5% 
      +/- 12.3; and mean peripheral VF, 75.5% +/- 17.1) despite normal spirometric
      results. After CPT, disparate changes in the distribution of ventilation defects 
      were observed but the average VDI and VF did not change significantly (mean VDI, 
      5.1 +/- 1.1; mean global VF, 83.5% +/- 12.2; and mean peripheral VF, 80.3% +/-
      12.2). There was no correlation between FEV(1) and VDI (rho = -0.041, P = .863)
      or global VF (rho = -0.196, P = .408) values but peripheral VF and VDI were
      correlated (rho = -0.563, P = .011). CONCLUSION: Although spirometric results
      indicate normal lung function, the mean VDI in patients (5.1) found in this study
      is well above the VDI in healthy subjects (1.6) reported in the literature. A
      single CPT session induces disparate changes in the distribution and extent of
      ventilation defects.
CI  - RSNA, 2010
FAU - Bannier, Elise
AU  - Bannier E
AD  - CREATIS LRMN, CNRS UMR 5220 INSERM U630, Universite de Lyon, 43 boulevard du 11
      Novembre, 69622 Villeurbanne, France.
FAU - Cieslar, Katarzyna
AU  - Cieslar K
FAU - Mosbah, Karim
AU  - Mosbah K
FAU - Aubert, Francoise
AU  - Aubert F
FAU - Duboeuf, Francois
AU  - Duboeuf F
FAU - Salhi, Zahir
AU  - Salhi Z
FAU - Gaillard, Sophie
AU  - Gaillard S
FAU - Berthezene, Yves
AU  - Berthezene Y
FAU - Cremillieux, Yannick
AU  - Cremillieux Y
FAU - Reix, Philippe
AU  - Reix P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Isotopes)
RN  - 206GF3GB41 (Helium)
SB  - IM
MH  - Administration, Inhalation
MH  - Adolescent
MH  - Airway Obstruction/*physiopathology/therapy
MH  - Child
MH  - Cystic Fibrosis/*physiopathology/therapy
MH  - Female
MH  - Helium/administration & dosage
MH  - Humans
MH  - Isotopes
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Pulmonary Ventilation
MH  - Reproducibility of Results
MH  - Respiratory Function Tests
MH  - Respiratory Therapy
MH  - Sensitivity and Specificity
MH  - Statistics, Nonparametric
MH  - Treatment Outcome
EDAT- 2010/03/24 06:00
MHDA- 2010/05/07 06:00
CRDT- 2010/03/24 06:00
PHST- 2010/03/24 06:00 [entrez]
PHST- 2010/03/24 06:00 [pubmed]
PHST- 2010/05/07 06:00 [medline]
AID - 255/1/225 [pii]
AID - 10.1148/radiol.09090039 [doi]
PST - ppublish
SO  - Radiology. 2010 Apr;255(1):225-32. doi: 10.1148/radiol.09090039.


PMID- 20308456
OWN - NLM
STAT- MEDLINE
DCOM- 20100506
LR  - 20220408
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 255
IP  - 1
DP  - 2010 Apr
TI  - Pediatric and adolescent lymphoma: comparison of whole-body STIR half-Fourier
      RARE MR imaging with an enhanced PET/CT reference for initial staging.
PG  - 182-90
LID - 10.1148/radiol.09091105 [doi]
AB  - PURPOSE: To compare the diagnostic performance of rapid whole-body anatomic
      magnetic resonance (MR) staging of pediatric and adolescent lymphoma to an
      enhanced positron emission tomographic (PET)/computed tomographic (CT) reference 
      standard. MATERIALS AND METHODS: Ethical permission was given by the University
      College London Hospital ethics committee, and informed written consent was
      obtained from all participants and/or parents or guardians. Thirty-one subjects
      (age range, 7.3-18.0 years; 18 male, 11 female) with histologically proved
      lymphoma were prospectively recruited. Pretreatment staging was performed with
      whole-body short inversion time inversion-recovery (STIR) half-Fourier rapid
      acquisition with relaxation enhancement (RARE) MR imaging, fluorine 18
      fluorodeoxyglucose PET/CT, and contrast agent-enhanced chest CT. Twenty-six
      subjects had posttreatment PET/CT and compromised our final cohort. Eleven nodal 
      and 11 extranodal sites per patient were assessed on MR imaging by two
      radiologists in consensus, with a nodal short-axis threshold of >1 cm and
      predefined extranodal positivity criteria. The same sites were independantly
      evaluated by two nuclear medicine physicians on PET/CT images. Disease positivity
      was defined as a maximum standardized uptake value >2.5 or nodal size >1 cm. An
      unblinded expert panel reevaluated the imaging findings, removing perceptual
      errors, and derived an enhanced PET/CT reference standard (taking into account
      chest CT and 3-month follow-up imaging) against which the reported and intrinsic 
      performance of MR imaging was assessed by using the kappa statistic. RESULTS:
      There was very good agreement between MR imaging and the enhanced PET/CT
      reference standard for nodal and extranodal staging (kappa = 0.96 and 0.86,
      respectively) which improved following elimination of perceptual errors (kappa = 
      0.97 and 0.91, respectively). The sensitivity and specificity of MR imaging
      (following removal of perceptual error) were 98% and 99%, respectively, for nodal
      disease and 91% and 99%, respectively, for extranodal disease. CONCLUSION:
      Whole-body STIR half-Fourier RARE MR imaging of pediatric and adolescent lymphoma
      can accurately depict nodal and extranodal disease and may provide an alternative
      nonionizing imaging method for anatomic disease assessment at initial staging.
CI  - RSNA, 2010
FAU - Punwani, Shonit
AU  - Punwani S
AD  - Department of Specialist Radiology, University College London Hospital, 235
      Euston Rd, Podium Level 2, London, England NW1 2BU.
FAU - Taylor, Stuart A
AU  - Taylor SA
FAU - Bainbridge, Alan
AU  - Bainbridge A
FAU - Prakash, Vineet
AU  - Prakash V
FAU - Bandula, Steven
AU  - Bandula S
FAU - De Vita, Enrico
AU  - De Vita E
FAU - Olsen, Oystein E
AU  - Olsen OE
FAU - Hain, Sharon F
AU  - Hain SF
FAU - Stevens, Nicola
AU  - Stevens N
FAU - Daw, Stephen
AU  - Daw S
FAU - Shankar, Ananth
AU  - Shankar A
FAU - Bomanji, Jamshed B
AU  - Bomanji JB
FAU - Humphries, Paul D
AU  - Humphries PD
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - 0 (Radiopharmaceuticals)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
RN  - 4419T9MX03 (Iohexol)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Contrast Media
MH  - Female
MH  - Fluorodeoxyglucose F18
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Iohexol
MH  - Lymphatic Metastasis
MH  - Lymphoma/*diagnosis
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Neoplasm Staging
MH  - Prospective Studies
MH  - Radiopharmaceuticals
MH  - Reference Standards
MH  - Sensitivity and Specificity
MH  - Tomography, Emission-Computed/methods
MH  - Tomography, X-Ray Computed/methods
EDAT- 2010/03/24 06:00
MHDA- 2010/05/07 06:00
CRDT- 2010/03/24 06:00
PHST- 2010/03/24 06:00 [entrez]
PHST- 2010/03/24 06:00 [pubmed]
PHST- 2010/05/07 06:00 [medline]
AID - 255/1/182 [pii]
AID - 10.1148/radiol.09091105 [doi]
PST - ppublish
SO  - Radiology. 2010 Apr;255(1):182-90. doi: 10.1148/radiol.09091105.


PMID- 20308453
OWN - NLM
STAT- MEDLINE
DCOM- 20100506
LR  - 20220418
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 255
IP  - 1
DP  - 2010 Apr
TI  - Improved detection of active multiple sclerosis lesions: 3D subtraction imaging.
PG  - 154-63
LID - 10.1148/radiol.09090814 [doi]
AB  - PURPOSE: To examine the benefits of using near-isotropic single-slab
      three-dimensional (3D) magnetic resonance (MR) imaging for the creation of
      subtraction images and to evaluate their performance in the detection of active
      multiple sclerosis (MS) brain lesions in comparison with two-dimensional (2D)
      subtraction images. MATERIALS AND METHODS: The study protocol was approved by the
      local ethics review board and all subjects gave written informed consent before
      investigation. Three-dimensional MR sequences, including double
      inversion-recovery, fluid-attenuated inversion recovery, T2-weighted, and
      T1-weighted magnetization-prepared rapid acquisition gradient-echo (MP-RAGE), and
      corresponding 2D sequences were performed twice in 14 patients (eight women, six 
      men; mean age, 37.6 years) with MS and nine age-matched healthy control subjects 
      (three women, six men; mean age, 31.7 years). Active lesions were scored by two
      independent raters, followed by a consensus reading. Lesion counts were evaluated
      by using negative binomial regression; interrater agreement was evaluated by
      using intraclass correlation coefficient. RESULTS: Three-dimensional subtraction 
      images had less residual misregistration and flow artifacts and depicted higher
      numbers of active lesions with greater interobserver agreement compared with 2D
      subtraction images. Among the 3D sequences, MP-RAGE subtraction imaging enabled
      detection of a significantly higher mean number of positive active MS lesions
      compared with 2D subtraction imaging (2.8 versus 1.7, P = .012), particularly
      infratentorial lesions (0.6 vs 0.1, P < .05), and a substantially higher
      (nonsignificant) mean number of small (<3 mm) lesions (0.6 vs 0.1, P > .05).
      CONCLUSION: Three-dimensional subtraction imaging, after image registration,
      produced better image quality, leading to increased detection of active MS
      lesions with greater interobserver agreement in comparison with 2D subtraction
      imaging; 3D MP-RAGE subtraction imaging represents a promising technique to
      increase sensitivity in ascertaining lesion dissemination in time and increase
      the power of MR imaging metrics for the evaluation of treatment effects in
      clinical trials.
CI  - RSNA, 2010
FAU - Moraal, Bastiaan
AU  - Moraal B
AD  - Department of Radiology, MS Center Amsterdam, VU University Medical Center, De
      Boelelaan 1117, 1081 HV Amsterdam, The Netherlands. b.moraal@vumc.nl
FAU - Wattjes, Mike P
AU  - Wattjes MP
FAU - Geurts, Jeroen J G
AU  - Geurts JJ
FAU - Knol, Dirk L
AU  - Knol DL
FAU - van Schijndel, Ronald A
AU  - van Schijndel RA
FAU - Pouwels, Petra J W
AU  - Pouwels PJ
FAU - Vrenken, Hugo
AU  - Vrenken H
FAU - Barkhof, Frederik
AU  - Barkhof F
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
CIN - Radiologe. 2010 Nov;50(11):953. PMID: 21076903
MH  - Adult
MH  - Artifacts
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Imaging, Three-Dimensional
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/*diagnosis
MH  - Subtraction Technique
EDAT- 2010/03/24 06:00
MHDA- 2010/05/07 06:00
CRDT- 2010/03/24 06:00
PHST- 2010/03/24 06:00 [entrez]
PHST- 2010/03/24 06:00 [pubmed]
PHST- 2010/05/07 06:00 [medline]
AID - 255/1/154 [pii]
AID - 10.1148/radiol.09090814 [doi]
PST - ppublish
SO  - Radiology. 2010 Apr;255(1):154-63. doi: 10.1148/radiol.09090814.


PMID- 20308450
OWN - NLM
STAT- MEDLINE
DCOM- 20100506
LR  - 20100323
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 255
IP  - 1
DP  - 2010 Apr
TI  - Functional MR imaging or Wada test: which is the better predictor of individual
      postoperative memory outcome?
PG  - 128-34
LID - 10.1148/radiol.09091079 [doi]
AB  - PURPOSE: To retrospectively determine whether blood oxygen level-dependent
      functional magnetic resonance (MR) imaging can aid prediction of postoperative
      memory changes in epileptic patients after temporal lobe surgery. MATERIALS AND
      METHODS: This study was approved by the local ethics committee, and informed
      consent was obtained from all patients. Data were analyzed from 25 patients (12
      women, 13 men; age range, 19-52 years) with refractory epilepsy in whom temporal 
      lobe surgery was performed after they underwent preoperative functional MR
      imaging, the Wada test, and neuropsychological testing. The functional MR imaging
      protocol included three different memory tasks (24-hour delayed recognition,
      encoding, and immediate recognition). Individual activations were measured in
      medial temporal lobe (MTL) regions of both hemispheres. The prognostic accuracy
      of functional MR imaging for prediction of postoperative memory changes was
      compared with the accuracy of the Wada test and preoperative neuropsychological
      testing by using a backward multiple regression analysis. RESULTS: An equation
      that was based on left functional MR imaging MTL activation during delayed
      recognition, side of the epileptic focus, and preoperative global verbal memory
      score was used to correctly predict worsening of verbal memory in 90% of
      patients. The right functional MR imaging MTL activation did not substantially
      correlate with the nonverbal memory outcome, which was only predicted by using
      the preoperative nonverbal global score. Wada test data were not good predictors 
      of changes in either verbal or nonverbal memory. CONCLUSION: Findings suggest
      that functional MR imaging activation during a delayed-recognition task is a
      better predictor of individual postoperative verbal memory outcome than is the
      Wada test.
CI  - RSNA, 2010
FAU - Dupont, Sophie
AU  - Dupont S
AD  - Epilepsy Unit, Neurology Clinic Paul Castaigne, Hopital de la Pitie-Salpetriere, 
      APHP, 47 boulevard de l'Hopital, 75651 Paris cedex 13, France.
      sophie.dupont@psl.aphp.fr
FAU - Duron, Emmanuelle
AU  - Duron E
FAU - Samson, Severine
AU  - Samson S
FAU - Denos, Marisa
AU  - Denos M
FAU - Volle, Emmanuelle
AU  - Volle E
FAU - Delmaire, Christine
AU  - Delmaire C
FAU - Navarro, Vincent
AU  - Navarro V
FAU - Chiras, Jacques
AU  - Chiras J
FAU - Lehericy, Stephane
AU  - Lehericy S
FAU - Samson, Yves
AU  - Samson Y
FAU - Baulac, Michel
AU  - Baulac M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adult
MH  - Electroencephalography
MH  - Epilepsy/*surgery
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Memory Disorders/*diagnosis
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Postoperative Complications/*diagnosis
MH  - Postoperative Period
MH  - Predictive Value of Tests
MH  - Regression Analysis
MH  - Retrospective Studies
MH  - Temporal Lobe/*surgery
MH  - Tomography, Emission-Computed, Single-Photon
MH  - *Verbal Learning
EDAT- 2010/03/24 06:00
MHDA- 2010/05/07 06:00
CRDT- 2010/03/24 06:00
PHST- 2010/03/24 06:00 [entrez]
PHST- 2010/03/24 06:00 [pubmed]
PHST- 2010/05/07 06:00 [medline]
AID - 255/1/128 [pii]
AID - 10.1148/radiol.09091079 [doi]
PST - ppublish
SO  - Radiology. 2010 Apr;255(1):128-34. doi: 10.1148/radiol.09091079.


PMID- 20308416
OWN - NLM
STAT- MEDLINE
DCOM- 20100603
LR  - 20200314
IS  - 0032-5791 (Print)
IS  - 0032-5791 (Linking)
VI  - 89
IP  - 4
DP  - 2010 Apr
TI  - Why using genetics to address welfare may not be a good idea.
PG  - 814-21
LID - 10.3382/ps.2009-00307 [doi]
AB  - Welfare of animals in livestock production systems is now widely defined in terms
      of 3 classes of measures: veterinary health, mental well-being (or feelings), and
      natural behaviors. Several well-documented points of tension exist among welfare 
      indicators in these 3 classes. Strategies that aim to improve welfare using
      genetics can increase resistance to disease and may also be able to relieve
      stress or injury. One strategy is to reduce the genetic proclivity of the bird to
      engage in behaviors that are frustrated in modern production systems. Another is 
      to develop strains less prone to behaviors hurtful to other hens. Yet another is 
      to make overall temperament a goal for genetic adjustments. These genetic
      approaches may score well in terms of veterinary and psychological well-being.
      Yet they also involve changes in behavioral repertoire and tendencies of the
      resulting bird. Although it has seemed reasonable to argue that such animals are 
      better off than frustrated or injured animals reflecting more species-typical
      behaviors, there is a point of view that holds that modification of a
      species-typical trait is ipso facto a decline in the well-being of the animal.
      Additionally, a significant amount of anecdotal evidence has been accumulated
      that suggests that many animal advocates and members of the public find
      manipulation of genetics to be an ethically unacceptable approach to animal
      welfare, especially when modifications in the environment could also be a
      response to welfare problems. Hence, though promising from one perspective,
      genetic strategies to improve welfare may not be acceptable to the public.
FAU - Thompson, P B
AU  - Thompson PB
AD  - Michigan State University, Department of Philosophy, 503 S. Kedzie Hall, East
      Lansing, MI 48824, USA. thomp649@msu.edu
LA  - eng
PT  - Journal Article
PL  - England
TA  - Poult Sci
JT  - Poultry science
JID - 0401150
SB  - IM
MH  - Animal Welfare/*standards
MH  - Animals
MH  - Attitude
MH  - Ethics
MH  - Genetic Engineering/*standards
MH  - Genomics/standards
MH  - Humans
MH  - Poultry/*genetics
EDAT- 2010/03/24 06:00
MHDA- 2010/06/04 06:00
CRDT- 2010/03/24 06:00
PHST- 2010/03/24 06:00 [entrez]
PHST- 2010/03/24 06:00 [pubmed]
PHST- 2010/06/04 06:00 [medline]
AID - S0032-5791(19)44840-2 [pii]
AID - 10.3382/ps.2009-00307 [doi]
PST - ppublish
SO  - Poult Sci. 2010 Apr;89(4):814-21. doi: 10.3382/ps.2009-00307.


PMID- 20307823
OWN - NLM
STAT- MEDLINE
DCOM- 20100505
LR  - 20220330
IS  - 1879-1972 (Electronic)
IS  - 1054-139X (Linking)
VI  - 46
IP  - 4
DP  - 2010 Apr
TI  - Randomized controlled clinical trial of yoga in the treatment of eating
      disorders.
PG  - 346-51
LID - 10.1016/j.jadohealth.2009.08.007 [doi]
AB  - PURPOSE: This was a pilot project designed to assess the effect of individualized
      yoga treatment on eating disorder outcomes among adolescents receiving outpatient
      care for diagnosed eating disorders (anorexia nervosa, bulimia nervosa, eating
      disorder not otherwise specified). METHODS: A total of 50 girls and 4 boys aged
      11-21 years were randomized to an 8-week trial of standard care vs.
      individualized yoga plus standard care. Of these, 27 were randomized to standard 
      care and 26 to yoga plus standard care (attrition: n = 4). Standard care (every
      other week physician and/or dietician appointments) was required to meet ethical 
      guidelines. The No Yoga group was offered yoga after study completion as an
      incentive to maintain participation. Outcomes evaluated at baseline, end of
      trial, and 1-month follow-up included Eating Disorder Examination (EDE), Body
      Mass Index (BMI), Beck Depression Inventory, State-Trait Anxiety Inventory, and
      Food Preoccupation questionnaire. RESULTS: The Yoga group demonstrated greater
      decreases in eating disorder symptoms. Specifically, the EDE scores decreased
      over time in the Yoga group, whereas the No Yoga group showed some initial
      decline but then returned to baseline EDE levels at week 12. Food preoccupation
      was measured before and after each yoga session, and decreased significantly
      after all sessions. Both groups maintained current BMI levels and decreased in
      anxiety and depression over time. CONCLUSIONS: Individualized yoga treatment
      decreased EDE scores at 12 weeks, and significantly reduced food preoccupation
      immediately after yoga sessions. Yoga treatment did not have a negative effect on
      BMI. Results suggest that individualized yoga therapy holds promise as adjunctive
      therapy to standard care.
CI  - Copyright 2010 Society for Adolescent Medicine. Published by Elsevier Inc. All
      rights reserved.
FAU - Carei, T Rain
AU  - Carei TR
AD  - Department of Adolescent Medicine, Seattle Children's Hospital, Seattle,
      Washington, USA. trcarei@doc1.wa.sov
FAU - Fyfe-Johnson, Amber L
AU  - Fyfe-Johnson AL
FAU - Breuner, Cora C
AU  - Breuner CC
FAU - Brown, Margaret A
AU  - Brown MA
LA  - eng
GR  - M01 RR000037-450988/RR/NCRR NIH HHS/United States
GR  - M01 RR000037-460988/RR/NCRR NIH HHS/United States
GR  - UL1 RR025014/RR/NCRR NIH HHS/United States
GR  - M01 RR000037-475449/RR/NCRR NIH HHS/United States
GR  - UL1RR025014-1/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
DEP - 20091103
PL  - United States
TA  - J Adolesc Health
JT  - The Journal of adolescent health : official publication of the Society for
      Adolescent Medicine
JID - 9102136
SB  - IM
MH  - Adolescent
MH  - Adolescent Behavior/*psychology
MH  - Anorexia Nervosa/rehabilitation
MH  - *Body Image
MH  - Body Mass Index
MH  - Bulimia Nervosa/rehabilitation
MH  - Child
MH  - Cognitive Behavioral Therapy/methods
MH  - Combined Modality Therapy
MH  - Feeding and Eating Disorders/psychology/*rehabilitation
MH  - Female
MH  - Humans
MH  - Male
MH  - Treatment Outcome
MH  - *Yoga
MH  - Young Adult
PMC - PMC2844876
MID - NIHMS157337
EDAT- 2010/03/24 06:00
MHDA- 2010/05/06 06:00
CRDT- 2010/03/24 06:00
PHST- 2009/03/27 00:00 [received]
PHST- 2009/08/19 00:00 [revised]
PHST- 2009/08/25 00:00 [accepted]
PHST- 2010/03/24 06:00 [entrez]
PHST- 2010/03/24 06:00 [pubmed]
PHST- 2010/05/06 06:00 [medline]
AID - S1054-139X(09)00334-6 [pii]
AID - 10.1016/j.jadohealth.2009.08.007 [doi]
PST - ppublish
SO  - J Adolesc Health. 2010 Apr;46(4):346-51. doi: 10.1016/j.jadohealth.2009.08.007.
      Epub 2009 Nov 3.


PMID- 20307370
OWN - NLM
STAT- MEDLINE
DCOM- 20100923
LR  - 20100618
IS  - 1478-9523 (Electronic)
IS  - 1478-9515 (Linking)
VI  - 8
IP  - 2
DP  - 2010 Jun
TI  - How might Levinas' concept of the other's priority and Derrida's unconditional
      hospitality contribute to the philosophy of the modern hospice movement?
PG  - 215-20
LID - 10.1017/S1478951509990952 [doi]
AB  - Hospitality is commonly referred as one of the meanings of hospes, the Latin word
      which is also the root of hospice. This article explores the semantics of the
      word hospice - the seal of identity of modern hospice movement - and attempts to 
      integrate the meaning of hospitality into the modern hospice movement, understood
      as unconditional reception. Therefore, the article analyzes the concept of
      unconditional hospitality, developed by Jacques Derrida and that of ethical
      responsibility proposed by Emmanuel Levinas based on the phenomenological
      experience of the other. From this point of view, these two concepts tie in with 
      the meaning of hospice, bringing substantial grounding elements to the hospice
      movement for the construction of a protective ethos.
FAU - Floriani, Ciro Augusto
AU  - Floriani CA
AD  - Bioethics Council, Brazilian National Cancer Institute, Rio de Janeiro, Brazil.
      ciroafloriani@gmail.com
FAU - Schramm, Fermin Roland
AU  - Schramm FR
LA  - eng
PT  - Biography
PT  - Historical Article
PT  - Journal Article
DEP - 20100323
PL  - England
TA  - Palliat Support Care
JT  - Palliative & supportive care
JID - 101232529
SB  - IM
MH  - Empathy
MH  - Ethical Theory/history
MH  - Ethics, Medical/*history
MH  - History, 20th Century
MH  - History, 21st Century
MH  - History, Ancient
MH  - Hospice Care/*history
MH  - Humans
MH  - Moral Obligations
MH  - Patient Advocacy/*history
MH  - Philosophy, Medical/*history
MH  - Professional-Patient Relations
MH  - Semantics
PS  - Derrida J
FPS - Derrida, Jacques
PS  - Levinas E
FPS - Levinas, Emmanuel
EDAT- 2010/03/24 06:00
MHDA- 2010/09/24 06:00
CRDT- 2010/03/24 06:00
PHST- 2010/03/24 06:00 [entrez]
PHST- 2010/03/24 06:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
AID - S1478951509990952 [pii]
AID - 10.1017/S1478951509990952 [doi]
PST - ppublish
SO  - Palliat Support Care. 2010 Jun;8(2):215-20. doi: 10.1017/S1478951509990952. Epub 
      2010 Mar 23.


PMID- 20307290
OWN - NLM
STAT- MEDLINE
DCOM- 20130204
LR  - 20220309
IS  - 1471-2458 (Electronic)
IS  - 1471-2458 (Linking)
VI  - 10
DP  - 2010 Mar 22
TI  - Paniya Voices: a Participatory Poverty and Health Assessment among a marginalized
      South Indian tribal population.
PG  - 149
LID - 10.1186/1471-2458-10-149 [doi]
AB  - BACKGROUND: In India, indigenous populations, known as Adivasi or Scheduled
      Tribes (STs), are among the poorest and most marginalized groups. 'Deprived' ST
      groups tend to display high levels of resignation and to lack the capacity to
      aspire; consequently their health perceptions often do not adequately correspond 
      to their real health needs. Moreover, similar to indigenous populations
      elsewhere, STs often have little opportunity to voice perspectives framed within 
      their own cultural worldviews. We undertook a study to gather policy-relevant
      data on the views, experiences, and priorities of a marginalized and previously
      enslaved tribal group in South India, the Paniyas, who have little 'voice' or
      power over their own situation. METHODS/DESIGN: We implemented a Participatory
      Poverty and Health Assessment (PPHA). We adopted guiding principles and an
      ethical code that promote respect for Paniya culture and values. The PPHA,
      informed by a vulnerability framework, addressed five key themes (health and
      illness, well-being, institutions, education, gender) using participatory
      approaches and qualitative methods. We implemented the PPHA in five Paniya
      colonies (clusters of houses in a small geographical area) in a gram panchayat
      (lowest level decentralized territorial unit) to generate data that can be
      quickly disseminated to decision-makers through interactive workshops and public 
      forums. PRELIMINARY FINDINGS: Findings indicated that the Paniyas are caught in
      multiple 'vulnerability traps', that is, they view their situation as vicious
      cycles from which it is difficult to break free. CONCLUSION: The PPHA is a
      potentially useful approach for global health researchers working with
      marginalized communities to implement research initiatives that will address
      those communities' health needs in an ethical and culturally appropriate manner.
FAU - Mohindra, Ks
AU  - Mohindra K
AD  - Centre de recherche du Centre hospitalier de l'Universite de Montreal, Montreal, 
      Canada. katia.mohindra@gmail.com
FAU - Narayana, D
AU  - Narayana D
FAU - Harikrishnadas, Ck
AU  - Harikrishnadas C
FAU - Anushreedha, Ss
AU  - Anushreedha S
FAU - Haddad, Slim
AU  - Haddad S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100322
PL  - England
TA  - BMC Public Health
JT  - BMC public health
JID - 100968562
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Community-Based Participatory Research
MH  - Cultural Competency
MH  - Feasibility Studies
MH  - Female
MH  - Health Promotion/*methods
MH  - Health Status
MH  - Humans
MH  - India
MH  - Life Style
MH  - Male
MH  - *Population Groups/psychology/statistics & numerical data
MH  - *Poverty Areas
MH  - Public Health Practice/standards
MH  - Residence Characteristics
MH  - Social Facilitation
MH  - *Vulnerable Populations
PMC - PMC2848202
EDAT- 2010/03/24 06:00
MHDA- 2013/02/05 06:00
CRDT- 2010/03/24 06:00
PHST- 2009/05/05 00:00 [received]
PHST- 2010/03/22 00:00 [accepted]
PHST- 2010/03/24 06:00 [entrez]
PHST- 2010/03/24 06:00 [pubmed]
PHST- 2013/02/05 06:00 [medline]
AID - 1471-2458-10-149 [pii]
AID - 10.1186/1471-2458-10-149 [doi]
PST - epublish
SO  - BMC Public Health. 2010 Mar 22;10:149. doi: 10.1186/1471-2458-10-149.


PMID- 20307281
OWN - NLM
STAT- MEDLINE
DCOM- 20100706
LR  - 20220321
IS  - 1741-7015 (Electronic)
IS  - 1741-7015 (Linking)
VI  - 8
DP  - 2010 Mar 22
TI  - Current sample size conventions: flaws, harms, and alternatives.
PG  - 17
LID - 10.1186/1741-7015-8-17 [doi]
AB  - BACKGROUND: The belief remains widespread that medical research studies must have
      statistical power of at least 80% in order to be scientifically sound, and peer
      reviewers often question whether power is high enough. DISCUSSION: This
      requirement and the methods for meeting it have severe flaws. Notably, the true
      nature of how sample size influences a study's projected scientific or practical 
      value precludes any meaningful blanket designation of <80% power as "inadequate".
      In addition, standard calculations are inherently unreliable, and focusing only
      on power neglects a completed study's most important results: estimates and
      confidence intervals. Current conventions harm the research process in many ways:
      promoting misinterpretation of completed studies, eroding scientific integrity,
      giving reviewers arbitrary power, inhibiting innovation, perverting ethical
      standards, wasting effort, and wasting money. Medical research would benefit from
      alternative approaches, including established value of information methods,
      simple choices based on cost or feasibility that have recently been justified,
      sensitivity analyses that examine a meaningful array of possible findings, and
      following previous analogous studies. To promote more rational approaches,
      research training should cover the issues presented here, peer reviewers should
      be extremely careful before raising issues of "inadequate" sample size, and
      reports of completed studies should not discuss power. SUMMARY: Common
      conventions and expectations concerning sample size are deeply flawed, cause
      serious harm to the research process, and should be replaced by more rational
      alternatives.
FAU - Bacchetti, Peter
AU  - Bacchetti P
AD  - Department of Epidemiology and Biostatistics, University of California, San
      Francisco, CA 94143, USA. peter@biostat.ucsf.edu
LA  - eng
GR  - UL1 RR024131/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20100322
PL  - England
TA  - BMC Med
JT  - BMC medicine
JID - 101190723
SB  - IM
MH  - Biomedical Research/*methods
MH  - Humans
MH  - Sample Size
MH  - Statistics as Topic/*methods
RF  - 35
PMC - PMC2856520
EDAT- 2010/03/24 06:00
MHDA- 2010/07/07 06:00
CRDT- 2010/03/24 06:00
PHST- 2009/12/16 00:00 [received]
PHST- 2010/03/22 00:00 [accepted]
PHST- 2010/03/24 06:00 [entrez]
PHST- 2010/03/24 06:00 [pubmed]
PHST- 2010/07/07 06:00 [medline]
AID - 1741-7015-8-17 [pii]
AID - 10.1186/1741-7015-8-17 [doi]
PST - epublish
SO  - BMC Med. 2010 Mar 22;8:17. doi: 10.1186/1741-7015-8-17.


PMID- 20307152
OWN - NLM
STAT- MEDLINE
DCOM- 20100622
LR  - 20191210
IS  - 1440-1665 (Electronic)
IS  - 1039-8562 (Linking)
VI  - 18
IP  - 2
DP  - 2010 Apr
TI  - College activities and the ethics of advertising.
PG  - 101-5
LID - 10.3109/10398561003665577 [doi]
AB  - OBJECTIVES: The aim of this paper is to examine whether advertising in the
      College journals and at RANZCP Congress, in particular from pharmaceutical
      companies, gives rise to a conflict of interests, and to discuss how this should 
      be managed. CONCLUSIONS: While advertising will often represent a conflict of
      interests, banning advertising from the College journals or Congress is unlikely 
      to the best way to manage this. Conflicts of interest may be better managed by
      development of clear policies on advertisements, broadening the advertising base 
      (i.e. beyond pharmaceutical companies), checking the accuracy of advertisements, 
      and, in the case of Congress, ceasing sponsored symposia.
FAU - Ryan, Christopher
AU  - Ryan C
AD  - Discipline of Psychiatry and Centre for Values, Ethics and the Law in Medicine,
      University of Sydney, NSW, Australia. christopher.ryan@sydney.edu.au
FAU - Walter, Garry
AU  - Walter G
FAU - Robertson, Michael
AU  - Robertson M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Australas Psychiatry
JT  - Australasian psychiatry : bulletin of Royal Australian and New Zealand College of
      Psychiatrists
JID - 9613603
SB  - IM
MH  - Advertising/*ethics
MH  - Conflict of Interest
MH  - Congresses as Topic/*ethics
MH  - Drug Industry/*ethics/methods
MH  - Editorial Policies
MH  - Financial Support/*ethics
MH  - Humans
MH  - Periodicals as Topic/*ethics
MH  - Policy Making
MH  - Publishing/ethics
MH  - *Universities
EDAT- 2010/03/24 06:00
MHDA- 2010/06/23 06:00
CRDT- 2010/03/24 06:00
PHST- 2010/03/24 06:00 [entrez]
PHST- 2010/03/24 06:00 [pubmed]
PHST- 2010/06/23 06:00 [medline]
AID - 10.3109/10398561003665577 [doi]
PST - ppublish
SO  - Australas Psychiatry. 2010 Apr;18(2):101-5. doi: 10.3109/10398561003665577.


PMID- 20306613
OWN - NLM
STAT- MEDLINE
DCOM- 20100421
LR  - 20190923
IS  - 0278-4807 (Print)
IS  - 0278-4807 (Linking)
VI  - 35
IP  - 2
DP  - 2010 Mar-Apr
TI  - Palliative or hospice care? Understanding the similarities and differences.
PG  - 60-4
AB  - With advances in health care and medical technology, the focus of medical care
      has been on curing. As people live longer, the possibility of experiencing
      chronic and life-limiting disease not only increases but also spurs the ethical
      question "Is length of life or quality of life most important?" Palliative care
      may be confused with hospice care, as both focus on symptom management and
      improved quality of life for those with chronic life-limiting disease. A better
      understanding of each healthcare option is needed for appropriate and timely
      patient referral. The purpose of this article is to identify the similarities and
      differences between these two options, clarify when referral is appropriate for
      hospice or palliative care services, and discuss the nurse's role in caring for
      patients with chronic disease.
FAU - Batchelor, Nancy Henne
AU  - Batchelor NH
AD  - University of Cincinnati, OH, USA. nancy.batchelor@uc.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Rehabil Nurs
JT  - Rehabilitation nursing : the official journal of the Association of
      Rehabilitation Nurses
JID - 8104825
MH  - Health Services Accessibility
MH  - *Hospice Care
MH  - Humans
MH  - Insurance, Health, Reimbursement
MH  - Nurse's Role
MH  - *Palliative Care
MH  - Terminology as Topic
MH  - United States
EDAT- 2010/03/24 06:00
MHDA- 2010/04/22 06:00
CRDT- 2010/03/24 06:00
PHST- 2010/03/24 06:00 [entrez]
PHST- 2010/03/24 06:00 [pubmed]
PHST- 2010/04/22 06:00 [medline]
AID - 10.1002/j.2048-7940.2010.tb00032.x [doi]
PST - ppublish
SO  - Rehabil Nurs. 2010 Mar-Apr;35(2):60-4. doi: 10.1002/j.2048-7940.2010.tb00032.x.


PMID- 20306569
OWN - NLM
STAT- MEDLINE
DCOM- 20101103
LR  - 20220408
IS  - 1365-2346 (Electronic)
IS  - 0265-0215 (Linking)
VI  - 27
IP  - 4
DP  - 2010 Apr
TI  - Premedication with oral midazolam with or without parental presence.
PG  - 347-52
AB  - BACKGROUND AND OBJECTIVE: In this study, we aimed to investigate whether the
      combination of low-dose (0.25 mg kg(-1)) midazolam premedication with parental
      presence can effectively reduce anxiety at induction as well as provide a
      smoother emergence. METHODS: Institutional ethics committee approval and informed
      consent from one of the parents were obtained prior to the study. Sixty ASA grade
      I or II children undergoing surgery were enrolled in the study. Children were
      randomized to receive either 0.5 mg kg(-1) midazolam orally (group M) or 0.25 mg 
      kg(-1) midazolam orally with parental presence (group MP) or parental presence
      alone (group P). The child's anxiety and sedation scores were evaluated as 1-4
      points on the Anxiety Scale and as 0-4 points on the University of Michigan
      Sedation Scale (UMSS), respectively, at the entrance to the operating room and
      for tolerance to the face mask. Heart rate, the mean arterial blood pressure and 
      O2 saturation (%) were assessed at repeated intervals before and after induction.
      At the end of surgery, the child's Anxiety Scale score, UMSS score, Observer's
      Pain Scale (OPS) score and FLACC score were also assessed. RESULTS: There were no
      differences between groups in demographic variables and duration of surgery or
      anaesthesia. Mean blood pressure changes were similar between groups at measured 
      intervals, but the heart rate was higher in group M before and after induction of
      anaesthesia (P<0.05). UMSS score was greater in both midazolam groups (groups M
      and MP) in the preoperative period (P<0.05). Anxiety Scale scores for anxiolysis 
      were higher in groups M and MP than in group P (less anxious and more sedated) at
      20 min after premedication, at the entrance to the operating room and at mask
      tolerance time points (P<0.05). During recovery there was no significant
      difference in sedation, recovery scores or behavioural anxiety assessment between
      groups, Anxiety Scale score, UMSS score, FLACC score, Visual Analog Scale (VAS)
      score and Observer's Pain Scale score in groups MP, M and P. CONCLUSION:
      Preoperative administration of midazolam 0.5 mg kg(-1) for premedication alone,
      without parental presence at induction, and that of low-dose midazolam 0.25 mg
      kg(-1) for premedication with parental presence at induction are both equally
      effective in reducing separation anxiety and providing a smooth emergence.
      However, parental presence alone, without midazolam for premedication, is not an 
      adequate approach for this outcome. If the environment for parental presence is
      convenient, the dose of midazolam may be reduced and induction and emergence
      conditions may still be of high quality.
FAU - Kazak, Zuleyha
AU  - Kazak Z
AD  - Department of Anaesthesiology and Reanimation, Faculty of Medicine, Ufuk
      University, Mesa Hospital, Ankara, Turkey. kazakzuleyha@yahoo.com
FAU - Sezer, Gul B
AU  - Sezer GB
FAU - Yilmaz, Ali A
AU  - Yilmaz AA
FAU - Ates, Yesim
AU  - Ates Y
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - Eur J Anaesthesiol
JT  - European journal of anaesthesiology
JID - 8411711
RN  - 0 (Anesthetics, Intravenous)
RN  - R60L0SM5BC (Midazolam)
SB  - IM
MH  - Administration, Oral
MH  - Anesthetics, Intravenous/*administration & dosage
MH  - Anxiety, Separation/*prevention & control
MH  - Child
MH  - Child, Preschool
MH  - Dental Anxiety/diagnosis/*prevention & control
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Male
MH  - Midazolam/*administration & dosage
MH  - Neuropsychological Tests
MH  - Pain Measurement
MH  - *Parents
MH  - Premedication
MH  - Prospective Studies
MH  - Treatment Outcome
EDAT- 2010/03/23 06:00
MHDA- 2010/11/04 06:00
CRDT- 2010/03/23 06:00
PHST- 2010/03/23 06:00 [entrez]
PHST- 2010/03/23 06:00 [pubmed]
PHST- 2010/11/04 06:00 [medline]
AID - 10.1097/eja.0b013e328331a3bb [doi]
PST - ppublish
SO  - Eur J Anaesthesiol. 2010 Apr;27(4):347-52. doi: 10.1097/eja.0b013e328331a3bb.


PMID- 20306548
OWN - NLM
STAT- MEDLINE
DCOM- 20100413
LR  - 20210501
IS  - 0025-729X (Print)
IS  - 0025-729X (Linking)
VI  - 192
IP  - 5
DP  - 2010 Mar 1
TI  - A case study evaluation of ethics review systems for multicentre clinical trials.
PG  - 293
FAU - Olver, Ian N
AU  - Olver IN
LA  - eng
PT  - Comment
PT  - Letter
PL  - Australia
TA  - Med J Aust
JT  - The Medical journal of Australia
JID - 0400714
SB  - IM
CON - Med J Aust. 2009 Sep 7;191(5):280-2. PMID: 19740053
MH  - *Ethical Review
MH  - Ethics Committees, Clinical
MH  - *Ethics, Medical
MH  - Humans
MH  - Models, Organizational
MH  - Multicenter Studies as Topic/*ethics
MH  - New South Wales
EDAT- 2010/03/23 06:00
MHDA- 2010/04/14 06:00
CRDT- 2010/03/23 06:00
PHST- 2010/03/23 06:00 [entrez]
PHST- 2010/03/23 06:00 [pubmed]
PHST- 2010/04/14 06:00 [medline]
AID - 10.5694/j.1326-5377.2010.tb03516.x [doi]
PST - ppublish
SO  - Med J Aust. 2010 Mar 1;192(5):293. doi: 10.5694/j.1326-5377.2010.tb03516.x.


PMID- 20306547
OWN - NLM
STAT- MEDLINE
DCOM- 20100413
LR  - 20210501
IS  - 0025-729X (Print)
IS  - 0025-729X (Linking)
VI  - 192
IP  - 5
DP  - 2010 Mar 1
TI  - A case study evaluation of ethics review systems for multicentre clinical trials.
PG  - 293
FAU - Fitzpatrick, Kate L
AU  - Fitzpatrick KL
FAU - Boult, Margaret
AU  - Boult M
FAU - Fitridge, Robert A
AU  - Fitridge RA
LA  - eng
PT  - Letter
PT  - Comment
PL  - Australia
TA  - Med J Aust
JT  - The Medical journal of Australia
JID - 0400714
SB  - IM
CON - Med J Aust. 2009 Sep 7;191(5):280-2. PMID: 19740053
MH  - Aortic Aneurysm/surgery
MH  - Clinical Trials as Topic/*ethics
MH  - *Ethical Review/standards
MH  - Ethics Committees, Research
MH  - Humans
MH  - Multicenter Studies as Topic/*ethics
MH  - New South Wales
MH  - Outcome Assessment, Health Care
MH  - South Australia
EDAT- 2010/03/23 06:00
MHDA- 2010/04/14 06:00
CRDT- 2010/03/23 06:00
PHST- 2010/03/23 06:00 [entrez]
PHST- 2010/03/23 06:00 [pubmed]
PHST- 2010/04/14 06:00 [medline]
AID - 10.5694/j.1326-5377.2010.tb03515.x [doi]
PST - ppublish
SO  - Med J Aust. 2010 Mar 1;192(5):293. doi: 10.5694/j.1326-5377.2010.tb03515.x.


PMID- 20306376
OWN - NLM
STAT- MEDLINE
DCOM- 20101001
LR  - 20191210
IS  - 1439-4421 (Electronic)
IS  - 0941-3790 (Linking)
VI  - 72
IP  - 3
DP  - 2010 Mar
TI  - [Personal responsibility for health. An interdisciplinary discussion on obesity
      as an example].
PG  - 161-2
LID - 10.1055/s-0029-1233470 [doi]
AB  - Considering obesity as an example, the present study has developed an ethical,
      legal and psychological understanding of personal responsibility, which aims at
      enabling and activating health promoting behaviour. Enhancing individual
      capabilities and modifying social and political factors that have an effect on
      individual behaviour are highlighted as a promising, appropriate and ethically
      sound strategy of prevention.
CI  - Georg Thieme Verlag KG Stuttgart. New York.
FAU - Ried, J
AU  - Ried J
AD  - ELSA-Nachwuchsforschergruppe Psychosoziale, ethische und rechtliche Konsequenzen 
      genetischer Befunde bei Adipositas, Philipps-Universitat Marburg. ried@staff
      .uni-marburg.de
FAU - Dabrock, P
AU  - Dabrock P
FAU - Schneider, D
AU  - Schneider D
FAU - Voit, W
AU  - Voit W
FAU - Rief, W
AU  - Rief W
FAU - Hilbert, A
AU  - Hilbert A
LA  - ger
PT  - Journal Article
TT  - Verantwortung fur die eigene Gesundheit. Eine interdisziplinare Diskussion am
      Beispiel der Adipositas.
DEP - 20100319
PL  - Germany
TA  - Gesundheitswesen
JT  - Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes
      (Germany))
JID - 9204210
SB  - IM
MH  - *Cooperative Behavior
MH  - Cross-Sectional Studies
MH  - Ethics, Medical
MH  - Feeding Behavior/ethics
MH  - Germany
MH  - *Health Behavior
MH  - Health Promotion/ethics
MH  - Humans
MH  - *Interdisciplinary Communication
MH  - *Life Style
MH  - National Health Programs
MH  - Obesity/epidemiology/*prevention & control
MH  - Power, Psychological
MH  - Self Care/ethics/methods
MH  - *Social Responsibility
EDAT- 2010/03/23 06:00
MHDA- 2010/10/05 06:00
CRDT- 2010/03/23 06:00
PHST- 2010/03/23 06:00 [entrez]
PHST- 2010/03/23 06:00 [pubmed]
PHST- 2010/10/05 06:00 [medline]
AID - 10.1055/s-0029-1233470 [doi]
PST - ppublish
SO  - Gesundheitswesen. 2010 Mar;72(3):161-2. doi: 10.1055/s-0029-1233470. Epub 2010
      Mar 19.


PMID- 20306352
OWN - NLM
STAT- MEDLINE
DCOM- 20100628
LR  - 20100322
IS  - 1545-5815 (Electronic)
IS  - 0898-9621 (Linking)
VI  - 17
IP  - 2
DP  - 2010 Mar
TI  - Unethical research and the C.I.A. Inspector General Report of 2004: observations 
      implicit in terms of the common rule.
PG  - 96-113
LID - 10.1080/08989621003708493 [doi]
AB  - Declassification of documents has given rise to the allegation that the Central
      Intelligence Agency may have conducted unethical research targeting detainee
      subjects. That allegation is examined using document analysis and the development
      of research goals and roles as defined in the Common Rule. This article sets
      aside issues as to whether enhanced interrogation techniques described in the
      declassified documents rise to legal definitions of torture. Instead, it presents
      a post hoc ethics review raising questions addressed by Institutional Review
      Boards recommending the filing of a for-cause noncompliance complaint with the
      Office for Human Research Protection against the Central Intelligence Agency.
FAU - Llanusa-Cestero, Renee
AU  - Llanusa-Cestero R
AD  - La Cesta Consultants, L.L.C., Miami, FL 33157, USA. rllanusa@bellsouth.net
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Account Res
JT  - Accountability in research
JID - 9100813
SB  - IM
MH  - Codes of Ethics
MH  - Coercion
MH  - Ethics Committees, Research
MH  - *Ethics, Research
MH  - *Human Rights Abuses
MH  - Humans
MH  - Interviews as Topic/methods
MH  - *Prisoners
MH  - United States
EDAT- 2010/03/23 06:00
MHDA- 2010/06/29 06:00
CRDT- 2010/03/23 06:00
PHST- 2010/03/23 06:00 [entrez]
PHST- 2010/03/23 06:00 [pubmed]
PHST- 2010/06/29 06:00 [medline]
AID - 920039753 [pii]
AID - 10.1080/08989621003708493 [doi]
PST - ppublish
SO  - Account Res. 2010 Mar;17(2):96-113. doi: 10.1080/08989621003708493.


PMID- 20306351
OWN - NLM
STAT- MEDLINE
DCOM- 20100628
LR  - 20100322
IS  - 1545-5815 (Electronic)
IS  - 0898-9621 (Linking)
VI  - 17
IP  - 2
DP  - 2010 Mar
TI  - Dr. Cezanne and the art of re(peat)search: competing interests and obligations in
      clinical research.
PG  - 85-95
LID - 10.1080/08989621003708451 [doi]
AB  - Clinician researchers have a number of roles, each of which carries specific
      obligations. There are times when these obligations may be in competition (up to 
      and including conflict) with each other. Using a narrative case study that
      describes a group of colleagues discussing their clinical department's
      participation in an industry-sponsored research protocol, we illustrate a number 
      of the obligations faced by clinician researchers, and discuss how competing
      interests and obligations can lead to ethical problems. The case study is
      followed by a discussion of the effect of university-industry relations on
      competing interests and obligations in both clinical research and the role of the
      university, and a suggested framework that could be used to determine when
      university involvement in commercial research is ethically acceptable.
FAU - Bluhm, Robyn L
AU  - Bluhm RL
AD  - Department of Philosophy and Religious Studies, Old Dominion University, Norfolk,
      Virginia, USA.
FAU - Downie, Jocelyn
AU  - Downie J
FAU - Nisker, Jeff
AU  - Nisker J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Account Res
JT  - Accountability in research
JID - 9100813
SB  - IM
MH  - Biomedical Research/*ethics
MH  - *Conflict of Interest
MH  - Humans
MH  - Industry/ethics
MH  - Interinstitutional Relations
MH  - Universities/ethics
EDAT- 2010/03/23 06:00
MHDA- 2010/06/29 06:00
CRDT- 2010/03/23 06:00
PHST- 2010/03/23 06:00 [entrez]
PHST- 2010/03/23 06:00 [pubmed]
PHST- 2010/06/29 06:00 [medline]
AID - 920039909 [pii]
AID - 10.1080/08989621003708451 [doi]
PST - ppublish
SO  - Account Res. 2010 Mar;17(2):85-95. doi: 10.1080/08989621003708451.


PMID- 20306349
OWN - NLM
STAT- MEDLINE
DCOM- 20100628
LR  - 20151119
IS  - 1545-5815 (Electronic)
IS  - 0898-9621 (Linking)
VI  - 17
IP  - 2
DP  - 2010 Mar
TI  - Disclosure of unknown harms in magnetic resonance imaging research.
PG  - 67-78
LID - 10.1080/08989621003641165 [doi]
AB  - Unknown harms are by their nature difficult to communicate. While magnetic
      resonance imaging (MRI) has known risks (e.g., metal projectiles, dislodgement of
      medical implants), this imaging modality also has potential unknown long-term
      negative health effects associated with its static magnetic fields. We carried
      out a research ethics board (REB) file review of previously approved MRI research
      studies and found that unknown risks were either left undisclosed or were
      inadequately disclosed to research participants and REBs. This article outlines
      issues raised by our REB file review and suggests steps that should be taken in
      order to satisfactorily communicate information about potential unknown harms of 
      MRI.
FAU - Marshall, Jennifer
AU  - Marshall J
AD  - Dalhousie University, Health Law Institute, Halifax, Nova Scotia, Canada.
      jennifer.marshall@dal.ca
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Account Res
JT  - Accountability in research
JID - 9100813
SB  - IM
MH  - Biomedical Research
MH  - Canada
MH  - Communication
MH  - Humans
MH  - Informed Consent
MH  - Magnetic Resonance Imaging/*adverse effects
MH  - Risk Assessment
MH  - Surveys and Questionnaires
MH  - *Truth Disclosure
EDAT- 2010/03/23 06:00
MHDA- 2010/06/29 06:00
CRDT- 2010/03/23 06:00
PHST- 2010/03/23 06:00 [entrez]
PHST- 2010/03/23 06:00 [pubmed]
PHST- 2010/06/29 06:00 [medline]
AID - 920039972 [pii]
AID - 10.1080/08989621003641165 [doi]
PST - ppublish
SO  - Account Res. 2010 Mar;17(2):67-78. doi: 10.1080/08989621003641165.


PMID- 20305970
OWN - NLM
STAT- MEDLINE
DCOM- 20100510
LR  - 20190907
IS  - 1678-9849 (Electronic)
IS  - 0037-8682 (Linking)
VI  - 43
IP  - 1
DP  - 2010 Jan-Feb
TI  - [Cross-sectional study on toxoplasmosis among female students on a university
      course in the Presidente Prudente region, State of Sao Paulo].
PG  - 59-61
LID - S0037-86822010000100013 [pii]
AB  - INTRODUCTION: Toxoplasmosis is a parasitic disease caused by the protozoan
      Toxoplasma gondii, which affects humans and other animals. The most severe form
      is congenital toxoplasmosis. Thus, it is important to establish the serological
      profile of women before pregnancy. This study aimed to analyze the serology of
      toxoplasmosis among female students on the nursing course at Unoeste
      (Universidade do Oeste Paulista), in Presidente Prudente, SP. METHODS: Blood
      samples were collected from 80 female students aged 18 to 35 years after they had
      signed the consent statement. Occurrences of anti-Toxoplasma gondii IgM and IgG
      antibodies were determined using the ELISA method. This study was approved by the
      institution's ethics committee and was conducted in the Immunology Laboratory at 
      Unoeste. RESULTS: Among the 80 blood samples analyzed, 27 female students were
      positive for IgG, whereas none of them were positive for IgM antibodies.
      CONCLUSIONS: Among the 80 female students, 53 (66.2%) would be susceptible to
      toxoplasmosis in a possible pregnancy. Twenty-seven of the female students
      (33.8%) were considered seropositive.
FAU - Souza, Cristiane de Oliveira
AU  - Souza Cde O
AD  - Departamento de Parasitologia, Universidade do Oeste Paulista, Presidente
      Prudente, SP. crisdioliver@hotmail.com
FAU - Tashima, Nair Toshiko
AU  - Tashima NT
FAU - Silva, Maria Aparecida da
AU  - Silva MA
FAU - Tumitan, Ana Rita Paladino
AU  - Tumitan AR
LA  - por
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
TT  - Estudo transversal de toxoplasmose em alunas de um curso superior da regiao de
      Presidente Prudente, Estado de Sao Paulo.
PL  - Brazil
TA  - Rev Soc Bras Med Trop
JT  - Revista da Sociedade Brasileira de Medicina Tropical
JID - 7507456
RN  - 0 (Antibodies, Protozoan)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antibodies, Protozoan/*blood
MH  - Brazil/epidemiology
MH  - Cross-Sectional Studies
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Immunoglobulin G/*blood
MH  - Immunoglobulin M/*blood
MH  - Seroepidemiologic Studies
MH  - Students, Nursing
MH  - Toxoplasma/*immunology
MH  - Toxoplasmosis/diagnosis/*epidemiology
MH  - Young Adult
EDAT- 2010/03/23 06:00
MHDA- 2010/05/11 06:00
CRDT- 2010/03/23 06:00
PHST- 2009/06/17 00:00 [received]
PHST- 2009/12/07 00:00 [accepted]
PHST- 2010/03/23 06:00 [entrez]
PHST- 2010/03/23 06:00 [pubmed]
PHST- 2010/05/11 06:00 [medline]
AID - S0037-86822010000100013 [pii]
AID - 10.1590/s0037-86822010000100013 [doi]
PST - ppublish
SO  - Rev Soc Bras Med Trop. 2010 Jan-Feb;43(1):59-61. doi:
      10.1590/s0037-86822010000100013.


PMID- 20305083
OWN - NLM
STAT- MEDLINE
DCOM- 20100603
LR  - 20100323
IS  - 1093-6793 (Print)
IS  - 1093-6793 (Linking)
VI  - 38
IP  - 1
DP  - 2010
TI  - Solitary confinement and mental illness in U.S. prisons: a challenge for medical 
      ethics.
PG  - 104-8
AB  - In recent years, prison officials have increasingly turned to solitary
      confinement as a way to manage difficult or dangerous prisoners. Many of the
      prisoners subjected to isolation, which can extend for years, have serious mental
      illness, and the conditions of solitary confinement can exacerbate their symptoms
      or provoke recurrence. Prison rules for isolated prisoners, however, greatly
      restrict the nature and quantity of mental health services that they can receive.
      In this article, we describe the use of isolation (called segregation by prison
      officials) to confine prisoners with serious mental illness, the psychological
      consequences of such confinement, and the response of U.S. courts and human
      rights experts. We then address the challenges and human rights responsibilities 
      of physicians confronting this prison practice. We conclude by urging
      professional organizations to adopt formal positions against the prolonged
      isolation of prisoners with serious mental illness.
FAU - Metzner, Jeffrey L
AU  - Metzner JL
AD  - 3300 East First Ave., Suite 590, Denver, CO 80206, USA.
      jeffrey.metzner@ucdenver.edu
FAU - Fellner, Jamie
AU  - Fellner J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Acad Psychiatry Law
JT  - The journal of the American Academy of Psychiatry and the Law
JID - 9708963
SB  - IM
MH  - *Ethics, Medical
MH  - Forensic Psychiatry/ethics
MH  - *Human Rights
MH  - Humans
MH  - Mental Disorders/*psychology
MH  - Prisoners/*psychology
MH  - Prisons/ethics
MH  - Social Isolation/*psychology
MH  - United States
EDAT- 2010/03/23 06:00
MHDA- 2010/06/04 06:00
CRDT- 2010/03/23 06:00
PHST- 2010/03/23 06:00 [entrez]
PHST- 2010/03/23 06:00 [pubmed]
PHST- 2010/06/04 06:00 [medline]
AID - 38/1/104 [pii]
PST - ppublish
SO  - J Am Acad Psychiatry Law. 2010;38(1):104-8.


PMID- 20305075
OWN - NLM
STAT- MEDLINE
DCOM- 20100603
LR  - 20100323
IS  - 1093-6793 (Print)
IS  - 1093-6793 (Linking)
VI  - 38
IP  - 1
DP  - 2010
TI  - Forensic evaluations and mandated reporting of child abuse.
PG  - 49-56
AB  - Statutes requiring physicians to report suspected cases of child abuse create a
      potential conflict for psychiatrists working in the forensic setting. What
      happens in the case in which a forensic psychiatrist, during the course of an
      evaluation requested by a defense attorney, learns about child abuse perpetrated 
      by the evaluee? A complicated legal, ethics-related, and interpersonal dilemma
      emerges. Reporting the abuse may contribute directly to further legal harm to the
      evaluee and place a strain on the relationship with the attorney. However, not
      reporting the abuse potentially involves ignoring a legal mandate and risking
      further harm to a child. This article first reviews mandated reporting statutes
      across the states. Next, the arguments for and against reporting are outlined.
      Existing solutions to the problem are reviewed, and several alternative solutions
      are explored. Finally, an approach to negotiating the dilemma that can be used by
      forensic psychiatrists in practice is suggested.
FAU - Kapoor, Reena
AU  - Kapoor R
AD  - Yale University School of Medicine, 34 Park Street, New Haven, CT 06519, USA.
      reena.kapoor@yale.edu
FAU - Zonana, Howard
AU  - Zonana H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Acad Psychiatry Law
JT  - The journal of the American Academy of Psychiatry and the Law
JID - 9708963
SB  - IM
MH  - Child
MH  - Child Abuse/*diagnosis
MH  - Forensic Psychiatry/*ethics/*legislation & jurisprudence
MH  - Humans
MH  - *Mandatory Reporting/ethics
MH  - United States
EDAT- 2010/03/23 06:00
MHDA- 2010/06/04 06:00
CRDT- 2010/03/23 06:00
PHST- 2010/03/23 06:00 [entrez]
PHST- 2010/03/23 06:00 [pubmed]
PHST- 2010/06/04 06:00 [medline]
AID - 38/1/49 [pii]
PST - ppublish
SO  - J Am Acad Psychiatry Law. 2010;38(1):49-56.


PMID- 20305073
OWN - NLM
STAT- MEDLINE
DCOM- 20100603
LR  - 20100323
IS  - 1093-6793 (Print)
IS  - 1093-6793 (Linking)
VI  - 38
IP  - 1
DP  - 2010
TI  - Commentary: the art of forensic report writing.
PG  - 43-5
AB  - As forensic psychiatry has matured into a well-recognized subspecialty,
      considerable agreement about the format and content of reports has emerged.
      Griffith et al. now turn their attention to the art of forensic writing. Their
      description of the forensic report as "performative narrative" may help to refine
      professional practice so long as the ethics-related pitfalls are identified and
      avoided.
FAU - Appelbaum, Kenneth L
AU  - Appelbaum KL
AD  - Center for Health Policy and Research, University of Massachusetts Medical
      School, 333 South Street, 13E779, Shrewsbury, MA 01545-2732, USA.
      kenneth.appelbaum@umassmed.edu
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - J Am Acad Psychiatry Law
JT  - The journal of the American Academy of Psychiatry and the Law
JID - 9708963
SB  - IM
CON - J Am Acad Psychiatry Law. 2010;38(1):32-42. PMID: 20305072
MH  - *Expert Testimony
MH  - Forensic Psychiatry/*methods
MH  - Humans
MH  - *Narration
MH  - *Writing
EDAT- 2010/03/23 06:00
MHDA- 2010/06/04 06:00
CRDT- 2010/03/23 06:00
PHST- 2010/03/23 06:00 [entrez]
PHST- 2010/03/23 06:00 [pubmed]
PHST- 2010/06/04 06:00 [medline]
AID - 38/1/43 [pii]
PST - ppublish
SO  - J Am Acad Psychiatry Law. 2010;38(1):43-5.


PMID- 20305072
OWN - NLM
STAT- MEDLINE
DCOM- 20100603
LR  - 20100323
IS  - 1093-6793 (Print)
IS  - 1093-6793 (Linking)
VI  - 38
IP  - 1
DP  - 2010
TI  - Conceptualizing the forensic psychiatry report as performative narrative.
PG  - 32-42
AB  - Forensic psychiatry has evolved into a recognized specialty. Two core
      competencies, often overlooked but commonplace in forensic psychiatry, are the
      constructing of forensic reports and the presenting of oral testimony. This
      article concerns the written forensic report and conceptualizes it as
      performative writing. We first review the development of the forensic report's
      structure over the past 30 years or so and then apply constructs from other
      disciplines as we propose a process for creating narrative forensic reports. Such
      writing is grounded in the discipline of psychiatry, relies on ethics-based
      principles of respect for persons and truth-telling, and uses language to tell a 
      story that persuades the legal audience. We examine the impact of voice, pitfalls
      to avoid, and the concepts of witnessing and labeling, as we describe the process
      of formulating the narrative through the voice of the forensic expert.
FAU - Griffith, Ezra E H
AU  - Griffith EE
AD  - Department of Psychiatry, Yale University School of Medicine, 300 George Street, 
      Suite 901, New Haven, CT 06511, USA. ezra.griffith@yale.edu
FAU - Stankovic, Aleksandra
AU  - Stankovic A
FAU - Baranoski, Madelon
AU  - Baranoski M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Acad Psychiatry Law
JT  - The journal of the American Academy of Psychiatry and the Law
JID - 9708963
SB  - IM
CIN - J Am Acad Psychiatry Law. 2010;38(1):43-5. PMID: 20305073
CIN - J Am Acad Psychiatry Law. 2010;38(1):46-8. PMID: 20305074
MH  - *Expert Testimony
MH  - Forensic Psychiatry/*methods
MH  - Humans
MH  - *Narration
MH  - *Writing
EDAT- 2010/03/23 06:00
MHDA- 2010/06/04 06:00
CRDT- 2010/03/23 06:00
PHST- 2010/03/23 06:00 [entrez]
PHST- 2010/03/23 06:00 [pubmed]
PHST- 2010/06/04 06:00 [medline]
AID - 38/1/32 [pii]
PST - ppublish
SO  - J Am Acad Psychiatry Law. 2010;38(1):32-42.


PMID- 20304984
OWN - NLM
STAT- MEDLINE
DCOM- 20100513
LR  - 20131121
IS  - 1526-7598 (Electronic)
IS  - 0003-2999 (Linking)
VI  - 110
IP  - 5
DP  - 2010 May 1
TI  - Nicotinic acetylcholine receptor gene expression is altered in burn patients.
PG  - 1355-9
LID - 10.1213/ANE.0b013e3181d41512 [doi]
AB  - INTRODUCTION: Burn patients have been observed to be more susceptible to the
      hyperkalemic effect of the depolarizing muscle relaxant succinylcholine. Changes 
      in nicotinic acetylcholine receptor (nAChR) subunit composition may alter
      electrophysiologic, pharmacologic, and metabolic characteristics of the receptor 
      inducing hyperkalemia on exposure to succinylcholine. No studies have been
      performed that show the upregulation and/or alteration of nAChR subunit
      composition in human burn patients. The scarcity of studies performed on humans
      with burn injury is mainly attributable to the technical and ethical difficulties
      in obtaining muscle biopsies at different time frames of illness in these acutely
      injured patients. nAChRs are expressed in oral keratinocytes and are upregulated 
      or altered in smokers. However, no studies have addressed the expression of
      nAChRs in the oral mucosa of burn patients. METHODS: Buccal mucosal scrapings
      were collected from 9 burn patients and 6 control nonburn surgical intensive care
      unit patients. For burn and control patients, tissues were collected upon
      presentation (time: 0 hour) and at time points 12, 24, and 48 hours, 1 week, and 
      2 weeks. Gene expression of the nAChR subunits alpha1, alpha7, gamma, and epsilon
      were performed using real-time reverse transcriptase polymerase chain reaction.
      RESULTS: alpha7 and gamma nAChR genes were significantly upregulated in burn
      patients, whereas alpha1 and epsilon nAChR genes were minimally affected, showing
      no significant changes over time. DISCUSSION: Over the 2 weeks of measurement, an
      upregulation of the alpha7 and gamma genes occurred in both burn and control
      patients; however, the proportion of alpha7 and gamma subunit increases was
      significantly higher in burn patients than in control surgical intensive care
      unit patients. The relationship between the thermal injury and the observed
      alteration in gene expression suggests a possible cause/effect relationship. This
      effect was observed at a site not affected by the burn injury and in nonmuscle
      tissues, thus emphasizing the systemic nature of the effect caused by the thermal
      injury. Because gene expression is the basis of protein production, the
      upregulation of alpha7 and gamma genes might translate into more alpha7 and gamma
      protein subunits. These proteins can also combine with each other or with other
      types of subunits (alpha1, beta, epsilon . . .) to form nAChRs with altered
      electrophysiologic characteristics leading to the observed abnormal clinical
      outcomes. CONCLUSION: Thermal injury may infer a systemic effect because
      upregulation/alteration of nAChRs occurs in nonmuscle tissues distant from the
      site of injury. The effect of thermal injury on nAChR gene subunits can be
      studied using a minimally invasive method (buccal mucosal scraping) and a highly 
      sensitive technology (real-time reverse transcriptase polymerase chain reaction) 
      obviating the need for more invasive methods.
FAU - Osta, Walid A
AU  - Osta WA
AD  - Department of Anesthesia,Wayne State University/Detroit Medical Center, Detroit, 
      MI 48201, USA. wosta@med.wayne.edu
FAU - El-Osta, Mohamed A
AU  - El-Osta MA
FAU - Pezhman, Eric A
AU  - Pezhman EA
FAU - Raad, Robert A
AU  - Raad RA
FAU - Ferguson, Kris
AU  - Ferguson K
FAU - McKelvey, George M
AU  - McKelvey GM
FAU - Marsh, Harold M
AU  - Marsh HM
FAU - White, Michael
AU  - White M
FAU - Perov, Samuel
AU  - Perov S
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20100319
PL  - United States
TA  - Anesth Analg
JT  - Anesthesia and analgesia
JID - 1310650
RN  - 0 (CHRNE protein, human)
RN  - 0 (CHRNG protein, human)
RN  - 0 (Chrna7 protein, human)
RN  - 0 (DNA Primers)
RN  - 0 (Receptors, Nicotinic)
RN  - 0 (alpha7 Nicotinic Acetylcholine Receptor)
RN  - 63231-63-0 (RNA)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Adult
MH  - Burns/*genetics/*metabolism
MH  - DNA/biosynthesis/isolation & purification
MH  - DNA Primers
MH  - Female
MH  - Gene Expression Regulation/*genetics/physiology
MH  - Humans
MH  - Male
MH  - Mouth Mucosa/metabolism
MH  - RNA/biosynthesis/isolation & purification
MH  - Receptors, Nicotinic/*genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Up-Regulation
MH  - alpha7 Nicotinic Acetylcholine Receptor
EDAT- 2010/03/23 06:00
MHDA- 2010/05/14 06:00
CRDT- 2010/03/23 06:00
PHST- 2010/03/23 06:00 [entrez]
PHST- 2010/03/23 06:00 [pubmed]
PHST- 2010/05/14 06:00 [medline]
AID - ANE.0b013e3181d41512 [pii]
AID - 10.1213/ANE.0b013e3181d41512 [doi]
PST - ppublish
SO  - Anesth Analg. 2010 May 1;110(5):1355-9. doi: 10.1213/ANE.0b013e3181d41512. Epub
      2010 Mar 19.


PMID- 20304661
OWN - NLM
STAT- MEDLINE
DCOM- 20110406
LR  - 20101105
IS  - 1878-4119 (Electronic)
IS  - 1010-5182 (Linking)
VI  - 38
IP  - 8
DP  - 2010 Dec
TI  - Ethical issues in instructions to authors of journals in
      oral-craniomaxillofacial/facial plastic surgery and related specialties.
PG  - 554-9
LID - 10.1016/j.jcms.2010.02.012 [doi]
AB  - BACKGROUND: Ethical standards of biomedical publications are associated with
      editorial leadership, such as contents of instructions to authors and journal's
      mechanisms for research and publication ethics. OBJECTIVES: To compare ethical
      issues in the guidelines for authors in oral-craniomaxillofacial/facial plastic
      surgery (OCM-FPS) journals with those in plastic surgery and
      otorhinolaryngology/head and neck surgery (ORL-HNS) journals, and to evaluate the
      relationship between journal's impact factor (IF) and ethical issues in the
      instructions to authors. METHODS: This study used a cross-sectional study design.
      The predictor variables were journal's specialty and IF. The outcome variable was
      the presence of seven ethical issues in the online versions of journal's
      instructions to authors in October 2009. We included only journals with
      identifiable IF for 2008, published in English, French, German and Thai.
      Appropriate descriptive and univariate statistics were computed for all study
      variables. The level of statistical significance was set at P<0.05. RESULTS: The 
      sample was composed of 48 journals: seven OCM-FPS (14.6%), 14 plastic surgery
      (29.2%) and 27 ORL-HNS (56.2%) journals. Only four journals (8.3%) mentioned all 
      ethical issues in their guidelines for authors. Neither journal's specialty nor
      IF was linked to completeness of the ethical requirements. CONCLUSIONS: The
      results of this study suggest that ethical issues in the instructions to authors 
      of most IF-indexed journals in OCM-FPS, plastic surgery and ORL-HNS are
      incomplete, regardless of specialty and IF. There is room for substantial
      improvement to uphold scientific integrity of these surgical specialties.
CI  - Copyright (c) 2010 European Association for Cranio-Maxillo-Facial Surgery.
      Published by Elsevier Ltd. All rights reserved.
FAU - Pitak-Arnnop, Poramate
AU  - Pitak-Arnnop P
AD  - Department of Oral, Craniomaxillofacial and Facial Plastic Surgery, Faculty of
      Medicine, University Hospital of Leipzig, Leipzig, Germany.
FAU - Bauer, Ute
AU  - Bauer U
FAU - Dhanuthai, Kittipong
AU  - Dhanuthai K
FAU - Bruckner, Martin
AU  - Bruckner M
FAU - Herve, Christian
AU  - Herve C
FAU - Meningaud, Jean-Paul
AU  - Meningaud JP
FAU - Hemprich, Alexander
AU  - Hemprich A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20100320
PL  - Scotland
TA  - J Craniomaxillofac Surg
JT  - Journal of cranio-maxillo-facial surgery : official publication of the European
      Association for Cranio-Maxillo-Facial Surgery
JID - 8704309
SB  - IM
MH  - Authorship
MH  - Cross-Sectional Studies
MH  - Dental Research/*ethics/standards
MH  - Editorial Policies
MH  - *Ethics, Research
MH  - *Guidelines as Topic
MH  - Journal Impact Factor
MH  - Journalism, Dental/*standards
MH  - Periodicals as Topic/*ethics/standards
MH  - Specialties, Surgical
MH  - Surgery, Oral
MH  - Surgery, Plastic
EDAT- 2010/03/23 06:00
MHDA- 2011/04/07 06:00
CRDT- 2010/03/23 06:00
PHST- 2009/10/31 00:00 [received]
PHST- 2010/01/08 00:00 [revised]
PHST- 2010/02/10 00:00 [accepted]
PHST- 2010/03/23 06:00 [entrez]
PHST- 2010/03/23 06:00 [pubmed]
PHST- 2011/04/07 06:00 [medline]
AID - S1010-5182(10)00037-5 [pii]
AID - 10.1016/j.jcms.2010.02.012 [doi]
PST - ppublish
SO  - J Craniomaxillofac Surg. 2010 Dec;38(8):554-9. doi: 10.1016/j.jcms.2010.02.012.
      Epub 2010 Mar 20.


PMID- 20304607
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20111117
IS  - 1878-5921 (Electronic)
IS  - 0895-4356 (Linking)
VI  - 63
IP  - 10
DP  - 2010 Oct
TI  - Sampling and ethical issues in a multicenter study on health of people with
      intellectual disabilities.
PG  - 1091-100
LID - 10.1016/j.jclinepi.2009.12.001 [doi]
AB  - OBJECTIVES: To study health inequalities in persons with intellectual
      disabilities, representative and unbiased samples are needed. Little is known
      about sample recruitment in this vulnerable group. This study aimed to determine 
      differences in ethical procedures and sample recruitment in a multicenter
      research on health of persons with intellectual disabilities. Study questions
      regarded the practical sampling procedure, how ethical consent was obtained in
      each country, and which person gave informed consent for each study participant. 
      STUDY DESIGN AND SETTING: Exploratory, as part of a multicenter study, in 14
      European countries. After developing identical guidelines for all countries,
      partners collected data on health indicators by orally interviewing 1,269 persons
      with intellectual disabilities. Subsequently, semistructured interviews were
      carried out with partners and researchers. RESULTS: Identification of sufficient 
      study participants proved feasible. Sampling frames differed from nationally
      estimated proportions of persons with intellectual disabilities living with
      families or in residential settings. Sometimes, people with intellectual
      disabilities were hard to trace. Consent procedures and legal representation
      varied broadly. Nonresponse data proved unavailable. CONCLUSION: To build
      representative unbiased samples of vulnerable groups with limited academic
      capacities, international consensus on respectful consent procedures and tailored
      patient information is necessary.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Veenstra, Marja Y
AU  - Veenstra MY
AD  - Department of General Practice, CAPHRI Care and Public Health Research Institute,
      University of Maastricht.
FAU - Walsh, Patricia N
AU  - Walsh PN
FAU - van Schrojenstein Lantman-de Valk, Henny M J
AU  - van Schrojenstein Lantman-de Valk HM
FAU - Haveman, Meindert J
AU  - Haveman MJ
FAU - Linehan, Christine
AU  - Linehan C
FAU - Kerr, Mike P
AU  - Kerr MP
FAU - Weber, Germain
AU  - Weber G
FAU - Salvador-Carulla, Luis
AU  - Salvador-Carulla L
FAU - Carmen-Cara, Alexandra
AU  - Carmen-Cara A
FAU - Azema, Bernard
AU  - Azema B
FAU - Buono, Serafino
AU  - Buono S
FAU - Germanavicius, Arunas
AU  - Germanavicius A
FAU - Tossebro, Jan
AU  - Tossebro J
FAU - Maatta, Tuomo
AU  - Maatta T
FAU - van Hove, Geert
AU  - van Hove G
FAU - Moravec, Dasa
AU  - Moravec D
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20100320
PL  - United States
TA  - J Clin Epidemiol
JT  - Journal of clinical epidemiology
JID - 8801383
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Europe/epidemiology
MH  - Female
MH  - Health Services Needs and Demand/*ethics
MH  - Health Status Indicators
MH  - *Healthcare Disparities
MH  - Humans
MH  - Informed Consent/*ethics/legislation & jurisprudence
MH  - Intellectual Disability/*epidemiology
MH  - Male
MH  - Middle Aged
MH  - Patient Selection/ethics
MH  - Qualitative Research
MH  - Social Environment
MH  - Young Adult
EDAT- 2010/03/23 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/03/23 06:00
PHST- 2009/04/10 00:00 [received]
PHST- 2009/11/25 00:00 [revised]
PHST- 2009/12/20 00:00 [accepted]
PHST- 2010/03/23 06:00 [entrez]
PHST- 2010/03/23 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - S0895-4356(09)00386-2 [pii]
AID - 10.1016/j.jclinepi.2009.12.001 [doi]
PST - ppublish
SO  - J Clin Epidemiol. 2010 Oct;63(10):1091-100. doi: 10.1016/j.jclinepi.2009.12.001. 
      Epub 2010 Mar 20.


PMID- 20304527
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20211020
IS  - 1578-1275 (Electronic)
IS  - 0212-6567 (Linking)
VI  - 42
IP  - 10
DP  - 2010 Oct
TI  - [Crisis in family medicine: A bioethical perspective from the routine practice].
PG  - 528-33
LID - 10.1016/j.aprim.2009.12.011 [doi]
AB  - From the beginning, family medicine (FM) has brought health care nearer to the
      population. A crisis in FM is a good time to look at the social expectations and 
      to reformulate and to strengthen the principles that guide the specialty. An
      ethical reflection is presented on what to do from the microcosm of daily
      practice. Bureaucracy and trivialities cause a moral decline which prevents FM
      from offering the specific service that it should. Its visualisation as doorman
      to the system, a mere filter of banalities, an administration area or as a
      handkerchief for the system to cry on, draws a socially unacceptable caricature. 
      It is vital for FM to reach an effective compromise preferably directed at the
      most vulnerable groups or individuals. But it also urgently needs a sense of
      recovery as an area of human promotion, in which the professionals do not lose
      their moral capacity to have something to desire, want, achieve and enjoy.
CI  - Copyright (c) 2009 Elsevier Espana, S.L. All rights reserved.
FAU - Montero, Santiago Alvarez
AU  - Montero SA
AD  - Centro de Salud de Torrelodones, Madrid, Espana. santiago.am@telefonica.net
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Crisis en la medicina de familia: una perspectiva bioetica desde la practica
      diaria.
DEP - 20100320
PL  - Spain
TA  - Aten Primaria
JT  - Atencion primaria
JID - 9111075
SB  - IM
CIN - Aten Primaria. 2011 Dec;43(12):683. PMID: 21524821
MH  - *Bioethical Issues
MH  - Family Practice/*ethics
MH  - Humans
PMC - PMC7024477
EDAT- 2010/03/23 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/03/23 06:00
PHST- 2009/11/10 00:00 [received]
PHST- 2009/12/14 00:00 [revised]
PHST- 2009/12/21 00:00 [accepted]
PHST- 2010/03/23 06:00 [entrez]
PHST- 2010/03/23 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - S0212-6567(10)00065-X [pii]
AID - 10.1016/j.aprim.2009.12.011 [doi]
PST - ppublish
SO  - Aten Primaria. 2010 Oct;42(10):528-33. doi: 10.1016/j.aprim.2009.12.011. Epub
      2010 Mar 20.


PMID- 20304193
OWN - NLM
STAT- MEDLINE
DCOM- 20100819
LR  - 20181201
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 42
IP  - 2
DP  - 2010 Mar
TI  - Expression of pancreatic endocrine markers by mesenchymal stem cells from human
      umbilical cord vein.
PG  - 563-5
LID - 10.1016/j.transproceed.2010.01.032 [doi]
AB  - BACKGROUND: Mesenchymal stem cells (MSCs) from human umbilical cord vein have
      great potential for use in cell therapy because of their ease of isolation,
      expansion, and differentiation, in addition to their relative acceptance from the
      ethical point of view. Obtaining the umbilical cord at birth does not present any
      risk to either mother or child. OBJECTIVE: To isolate and promote in vitro
      expansion and differentiation of MSCs from human umbilical cord vein into cells
      with a pancreatic endocrine phenotype. METHODS: Mesenchymal stem cells obtained
      from human umbilical cord vein via collagenase digestion were characterized at
      cytochemistry and fluorescent-activated cell sorting, and expanded in vitro.
      Differentiation of MSCs into an endocrine phenotype was induced using
      high-glucose (23 mmol/L) medium containing nicotinamide, exendin-4, and
      2-mercaptoethanol. Expression of insulin, somatostatin, glucagon, and pancreatic 
      and duodenal homeobox 1 was analyzed using immunofluorescence. RESULTS: Cells
      isolated from the umbilical cord vein were MSCs as confirmed at cytochemistry and
      fluorescent-activated cell sorting. Expression of somatostatin, glucagon, and
      pancreatic and duodenal homeobox 1 by differentiated cells was demonstrated using
      immunofluorescence. Insulin was not expressed. CONCLUSIONS: The MSC
      differentiation protocol used in the present study induced expression of some
      endocrine markers. Insulin was not produced by these cells, probably because of
      incomplete induction of differentiation.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Santos, T M
AU  - Santos TM
AD  - Centro de Ciencias Biologicas e da Saude, Pontificia Universidade Catolica do
      Parana, Curitiba.
FAU - Percegona, L S
AU  - Percegona LS
FAU - Gonzalez, P
AU  - Gonzalez P
FAU - Calil, A
AU  - Calil A
FAU - Corradi Perini, C
AU  - Corradi Perini C
FAU - Faucz, F R
AU  - Faucz FR
FAU - Camara, N O S
AU  - Camara NO
FAU - Aita, C A M
AU  - Aita CA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - 0 (Antigens, CD)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Trans-Activators)
RN  - 0 (pancreatic and duodenal homeobox 1 protein)
RN  - 51110-01-1 (Somatostatin)
RN  - 9007-92-5 (Glucagon)
SB  - IM
MH  - Antigens, CD/analysis
MH  - Cell Differentiation
MH  - Cell Division
MH  - Female
MH  - Glucagon/genetics
MH  - Homeodomain Proteins/genetics
MH  - Humans
MH  - Islets of Langerhans/*physiology
MH  - Mesenchymal Stem Cells/cytology/*physiology
MH  - Phenotype
MH  - Pregnancy
MH  - Somatostatin/genetics
MH  - Trans-Activators/genetics
MH  - Umbilical Cord
MH  - Umbilical Veins/cytology/*physiology
EDAT- 2010/03/23 06:00
MHDA- 2010/08/20 06:00
CRDT- 2010/03/23 06:00
PHST- 2010/03/23 06:00 [entrez]
PHST- 2010/03/23 06:00 [pubmed]
PHST- 2010/08/20 06:00 [medline]
AID - S0041-1345(10)00123-5 [pii]
AID - 10.1016/j.transproceed.2010.01.032 [doi]
PST - ppublish
SO  - Transplant Proc. 2010 Mar;42(2):563-5. doi: 10.1016/j.transproceed.2010.01.032.


PMID- 20304040
OWN - NLM
STAT- MEDLINE
DCOM- 20101028
LR  - 20131121
IS  - 1872-7573 (Electronic)
IS  - 0378-8741 (Linking)
VI  - 129
IP  - 2
DP  - 2010 May 27
TI  - Antinociceptive effect of Zanthoxylum rhoifolium Lam. (Rutaceae) in models of
      acute pain in rodents.
PG  - 227-31
LID - 10.1016/j.jep.2010.03.009 [doi]
AB  - AIM OF THE STUDY: Zanthoxylum rhoifolium Lam. (Rutaceae) is locally known as
      "mamica de cadela", and its bark is popularly used for toothache and earache. The
      objective of this study was to investigate the antinociceptive effect of the
      ethanolic extract from this species' stem bark (EtOH), its fractions of partition
      (hexane-HEX, ethyl acetate-AcOEt, aqueous-AQ) and lupeol (a triterpene obtained
      from HEX) in models of acute pain. MATERIALS AND METHODS: Male and female Swiss
      mice (25-35 g, n=6-12 animals/group) were used to assess acute toxicity and
      nociception (Animal Ethics Committee/UFPI, No. 09/2008). Acute toxicity was
      studied up to 2 g/kg p.o. of EtOH. In the formalin test (2%, 20 microL/paw), the 
      licking time of the stimulated paw was quantified during the first 5 min (first
      phase) and at 15-30 min (second phase), 1h after oral treatment with EtOH, HEX,
      AcOEt or saline, and 30 min after use of morphine-MOR (5 mg/kg i.p.). The same
      response evoked by capsaicin (2 microg/20 microL/paw) was quantified during 5
      min, after administration of EtOH, HEX, AcOEt, AQ, saline and MOR. The licking
      time of the paw that was stimulated with glutamate (10 micromol/20 microL) was
      measured (15 min) after treatment with EtOH, HEX, AcOEt, AQ, lupeol, saline or
      MK801 (0.03 mg/kg, i.p.). Mice were submitted to the rota-rod task and open-field
      test in order to assess any non-specific muscle-relaxant or sedative effects of
      EtOH (250 mg/kg p.o.) and HEX (500 mg/kg p.o.). RESULTS: The animals did not
      exhibit any acute toxicity to EtOH (up to 2 g/kg p.o.), so it was not possible to
      calculate the LD50. EtOH, HEX and AcOEt (62.5-250 mg/kg) produced a significant
      antinociceptive effect in the formalin and capsaicin tests. However, AQ was
      ineffective. EtOH, HEX, AcOEt and lupeol reduced the glutamate-evoked nociceptive
      response, but AQ had no effect. EtOH and HEX did not alter the locomotion of
      animals in the open-field or rota-rod tests, which suggest a lack of a central
      depressant effect. CONCLUSION: The results confirm the popular use of Zanthoxylum
      rhoifolium as an analgesic, and contribute to the pharmacological knowledge of
      this species because it was shown that EtOH and its less polar partition
      fractions (HEX, AcOEt) have an antinociceptive effect in models of chemical
      nociception, and that lupeol appears to be one of the constituents responsible
      for this effect.
CI  - Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Pereira, S S
AU  - Pereira SS
AD  - Medicinal Plants Research Center, Federal University of Piaui, Teresina, Brazil.
FAU - Lopes, L S
AU  - Lopes LS
FAU - Marques, R B
AU  - Marques RB
FAU - Figueiredo, K A
AU  - Figueiredo KA
FAU - Costa, D A
AU  - Costa DA
FAU - Chaves, M H
AU  - Chaves MH
FAU - Almeida, F R C
AU  - Almeida FR
LA  - eng
PT  - Journal Article
DEP - 20100319
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Analgesics)
RN  - 0 (Pentacyclic Triterpenes)
RN  - 0 (Plant Extracts)
RN  - 1HG84L3525 (Formaldehyde)
RN  - 3K9958V90M (Ethanol)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 6LR8C1B66Q (Dizocilpine Maleate)
RN  - 76I7G6D29C (Morphine)
RN  - O268W13H3O (lupeol)
RN  - S07O44R1ZM (Capsaicin)
SB  - IM
MH  - Analgesics/pharmacology/*therapeutic use
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Capsaicin
MH  - Disease Models, Animal
MH  - Dizocilpine Maleate
MH  - Ethanol/pharmacology
MH  - Female
MH  - Formaldehyde
MH  - Glutamic Acid/metabolism
MH  - Locomotion/drug effects
MH  - Male
MH  - Mice
MH  - Morphine/pharmacology
MH  - Pain/chemically induced/*drug therapy
MH  - Pentacyclic Triterpenes/pharmacology/*therapeutic use
MH  - *Phytotherapy
MH  - Plant Bark
MH  - Plant Extracts/chemistry/pharmacology/*therapeutic use
MH  - Plant Stems
MH  - Zanthoxylum/*chemistry
EDAT- 2010/03/23 06:00
MHDA- 2010/10/29 06:00
CRDT- 2010/03/23 06:00
PHST- 2009/10/27 00:00 [received]
PHST- 2010/02/05 00:00 [revised]
PHST- 2010/03/10 00:00 [accepted]
PHST- 2010/03/23 06:00 [entrez]
PHST- 2010/03/23 06:00 [pubmed]
PHST- 2010/10/29 06:00 [medline]
AID - S0378-8741(10)00171-6 [pii]
AID - 10.1016/j.jep.2010.03.009 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2010 May 27;129(2):227-31. doi: 10.1016/j.jep.2010.03.009. Epub
      2010 Mar 19.


PMID- 20303033
OWN - NLM
STAT- MEDLINE
DCOM- 20100615
LR  - 20100715
IS  - 1873-6513 (Electronic)
IS  - 0885-3924 (Linking)
VI  - 39
IP  - 3
DP  - 2010 Mar
TI  - Dying tax free: the modern advance directive and patients' financial values.
PG  - 605-9
LID - 10.1016/j.jpainsymman.2009.12.003 [doi]
AB  - Advance directives are often used to help patients articulate their end-of-life
      treatment preferences and guide proxy decision makers in making health care
      decisions when patients cannot. This case study and commentary puts forth a
      situation in which a palliative care consultation team encountered a patient with
      an advance directive that instructed her proxy decision maker to consider estate 
      tax implications when making end-of-life decisions. Following presentation of the
      case, the authors focus on two ethical issues: 1) the appropriateness of
      considering patients' financial goals and values in medical decision making and
      2) whether certain kinds of patient values should be considered more or less
      relevant than others as reasons for expressed treatment preferences. Clinicians
      are encouraged to accept a wide range of patient values as relevant to the
      clinical decision-making process and to balance the influence of those values
      with more traditional notions of clinical harm and benefit.
CI  - (c) 2010 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. All rights
      reserved.
FAU - Kirk, Timothy W
AU  - Kirk TW
AD  - Department of History & Philosophy, City University of New York-York College,
      Jamaica, New York 11451, USA. timothy.kirk@york.cuny.edu
FAU - Luck, George R
AU  - Luck GR
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Pain Symptom Manage
JT  - Journal of pain and symptom management
JID - 8605836
SB  - IM
CIN - J Pain Symptom Manage. 2010 Jul;40(1):e14. PMID: 20619197
MH  - *Advance Directives
MH  - Aged, 80 and over
MH  - Decision Making
MH  - Female
MH  - Humans
MH  - Palliative Care/*economics/*ethics/legislation & jurisprudence
MH  - Shock, Septic/therapy
MH  - Taxes/*economics/legislation & jurisprudence
MH  - Terminal Care/*economics/*ethics/legislation & jurisprudence
EDAT- 2010/03/23 06:00
MHDA- 2010/06/16 06:00
CRDT- 2010/03/23 06:00
PHST- 2009/11/30 00:00 [received]
PHST- 2009/12/01 00:00 [accepted]
PHST- 2010/03/23 06:00 [entrez]
PHST- 2010/03/23 06:00 [pubmed]
PHST- 2010/06/16 06:00 [medline]
AID - S0885-3924(10)00100-4 [pii]
AID - 10.1016/j.jpainsymman.2009.12.003 [doi]
PST - ppublish
SO  - J Pain Symptom Manage. 2010 Mar;39(3):605-9. doi:
      10.1016/j.jpainsymman.2009.12.003.


PMID- 20302999
OWN - NLM
STAT- MEDLINE
DCOM- 20100713
LR  - 20211020
IS  - 1873-7714 (Electronic)
IS  - 0163-8343 (Linking)
VI  - 32
IP  - 2
DP  - 2010 Mar-Apr
TI  - Screening for suicidality in cancer patients using Item 9 of the nine-item
      patient health questionnaire; does the item score predict who requires further
      assessment?
PG  - 218-20
LID - 10.1016/j.genhosppsych.2009.11.011 [doi]
AB  - OBJECTIVE: To determine whether a higher score on Item 9 of the Patient Health
      Questionnaire-9 (range zero to three) was more likely to indicate suicidality as 
      determined at subsequent clinical interview in cancer outpatients. METHOD:
      Analysis of anonymized data (with ethical approval) obtained from the routine
      clinical administration of self-report questionnaires and telephone interviews to
      patients attending a cancer centre in the UK. RESULTS: Complete data were
      available on 330 patients. Those with higher scores on the item were more likely 
      to be suicidal at interview. However, a substantial number of those (54/235; 23%)
      who scored only one on the item were also found to be suicidal. CONCLUSIONS: A
      higher score on Item 9 of the PHQ-9 indicates a greater likelihood that the
      patient is suicidal. However, even patients who score only 1 may be suicidal and 
      consequently also require further assessment.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Walker, Jane
AU  - Walker J
AD  - Psychological Medicine Research, University of Edinburgh Cancer Research Centre, 
      Western General Hospital, Edinburgh EH4 2XR, UK. jane.walker@ed.ac.uk
FAU - Hansen, Christian Holm
AU  - Hansen CH
FAU - Hodges, Laura
AU  - Hodges L
FAU - Thekkumpurath, Parvez
AU  - Thekkumpurath P
FAU - O'Connor, Mark
AU  - O'Connor M
FAU - Sharma, Neelom
AU  - Sharma N
FAU - Kleiboer, Annet
AU  - Kleiboer A
FAU - Murray, Gordon
AU  - Murray G
FAU - Kroenke, Kurt
AU  - Kroenke K
FAU - Sharpe, Michael
AU  - Sharpe M
LA  - eng
GR  - G0800803/MRC_/Medical Research Council/United Kingdom
GR  - CRUK_/Cancer Research UK/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20100104
PL  - United States
TA  - Gen Hosp Psychiatry
JT  - General hospital psychiatry
JID - 7905527
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - *Health Surveys
MH  - Humans
MH  - Male
MH  - Mass Screening/*methods
MH  - Middle Aged
MH  - Neoplasms/*epidemiology/*psychology
MH  - Predictive Value of Tests
MH  - Suicide, Attempted/*psychology/*statistics & numerical data
MH  - *Surveys and Questionnaires
MH  - Young Adult
EDAT- 2010/03/23 06:00
MHDA- 2010/07/14 06:00
CRDT- 2010/03/23 06:00
PHST- 2009/09/06 00:00 [received]
PHST- 2009/11/20 00:00 [revised]
PHST- 2009/11/23 00:00 [accepted]
PHST- 2010/03/23 06:00 [entrez]
PHST- 2010/03/23 06:00 [pubmed]
PHST- 2010/07/14 06:00 [medline]
AID - S0163-8343(09)00239-4 [pii]
AID - 10.1016/j.genhosppsych.2009.11.011 [doi]
PST - ppublish
SO  - Gen Hosp Psychiatry. 2010 Mar-Apr;32(2):218-20. doi:
      10.1016/j.genhosppsych.2009.11.011. Epub 2010 Jan 4.


PMID- 20302671
OWN - NLM
STAT- MEDLINE
DCOM- 20100430
LR  - 20211020
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 11
DP  - 2010 Mar 21
TI  - Obstacles to researching the researchers: a case study of the ethical challenges 
      of undertaking methodological research investigating the reporting of randomised 
      controlled trials.
PG  - 28
LID - 10.1186/1745-6215-11-28 [doi]
AB  - BACKGROUND: Recent cohort studies of randomised controlled trials have provided
      evidence of within-study selective reporting bias; where statistically
      significant outcomes are more likely to be more completely reported compared to
      non-significant outcomes. Bias resulting from selective reporting can impact on
      meta-analyses, influencing the conclusions of systematic reviews, and in turn,
      evidence based clinical practice guidelines.In 2006 we received funding to
      investigate if there was evidence of within-study selective reporting in a cohort
      of RCTs submitted to New Zealand Regional Ethics Committees in 1998/99. This
      research involved accessing ethics applications, their amendments and annual
      reports, and comparing these with corresponding publications. We did not plan to 
      obtain informed consent from trialists to view their ethics applications for
      practical and scientific reasons. In November 2006 we sought ethical approval to 
      undertake the research from our institutional ethics committee. The Committee
      declined our application on the grounds that we were not obtaining informed
      consent from the trialists to view their ethics application. This initiated a
      seventeen month process to obtain ethical approval. This publication outlines
      what we planned to do, the issues we encountered, discusses the legal and ethical
      issues, and presents some potential solutions. DISCUSSION AND CONCLUSION:
      Methodological research such as this has the potential for public benefit and
      there is little or no harm for the participants (trialists) in undertaking it.
      Further, in New Zealand, there is freedom of information legislation, which in
      this circumstance, unambiguously provided rights of access and use of the
      information in the ethics applications. The decision of our institutional ethics 
      committee defeated this right and did not recognise the nature of this
      observational research. Methodological research, such as this, can be used to
      develop processes to improve quality in research reporting. Recognition of the
      potential benefit of this research in the broader research community, and those
      who sit on ethics committees, is perhaps needed. In addition, changes to the
      ethical review process which involve separation between those who review
      proposals to undertake methodological research using ethics applications, and
      those with responsibility for reviewing ethics applications for trials, should be
      considered. Finally, we contend that the research community could benefit from
      quality improvement approaches used in allied sectors.
FAU - McKenzie, Joanne E
AU  - McKenzie JE
AD  - School of Public Health and Preventive Medicine, Monash University, Melbourne,
      Australia. joanne.mckenzie@med.monash.edu.au
FAU - Herbison, G Peter
AU  - Herbison GP
FAU - Roth, Paul
AU  - Roth P
FAU - Paul, Charlotte
AU  - Paul C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100321
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
SB  - IM
MH  - Access to Information/*ethics/legislation & jurisprudence
MH  - *Bias
MH  - Confidentiality/ethics
MH  - *Data Interpretation, Statistical
MH  - Disclosure/ethics
MH  - Ethics Committees
MH  - Evidence-Based Medicine/*ethics/legislation & jurisprudence/statistics &
      numerical data
MH  - Humans
MH  - Informed Consent/ethics
MH  - New Zealand
MH  - Randomized Controlled Trials as Topic/*ethics/legislation &
      jurisprudence/statistics & numerical data
MH  - Reproducibility of Results
MH  - Research Design
MH  - Treatment Outcome
PMC - PMC2846843
EDAT- 2010/03/23 06:00
MHDA- 2010/05/01 06:00
CRDT- 2010/03/23 06:00
PHST- 2009/07/01 00:00 [received]
PHST- 2010/03/21 00:00 [accepted]
PHST- 2010/03/23 06:00 [entrez]
PHST- 2010/03/23 06:00 [pubmed]
PHST- 2010/05/01 06:00 [medline]
AID - 1745-6215-11-28 [pii]
AID - 10.1186/1745-6215-11-28 [doi]
PST - epublish
SO  - Trials. 2010 Mar 21;11:28. doi: 10.1186/1745-6215-11-28.


PMID- 20302439
OWN - NLM
STAT- MEDLINE
DCOM- 20100610
LR  - 20100323
IS  - 0963-8288 (Print)
IS  - 0963-8288 (Linking)
VI  - 32
IP  - 9
DP  - 2010
TI  - Lung transplant recipients' views on the integration of their new organs.
PG  - 713-22
LID - 10.3109/09638280903258860 [doi]
AB  - AIM: Although donorship issues and the integration of the new organs are the most
      distinguishing aspects of lung transplantation (LTx) compared to other kinds of
      'high-tech' medicine, there is a paucity of papers on that matter. Therefore, we 
      aimed to evaluate these aspects in young adult LTx recipients with at least
      1-year survival. METHODS: Semi-structured interviews; content analysis of
      specific parts of the interviews; frequency distributions of resulting
      categories. SAMPLE: Forty-five adults aged 18-42 years (mean: 32 +/- 5.5 years). 
      Post-transplant survival ranged from 1 to 11 years. RESULTS: The majority of
      recipients (60%) fulfilled criteria of denial towards the foreign organ and/or
      the donor. However, they were rather sensitive towards the ethical and
      psychological impact of the upcoming option of living donorship in LTx. Also, the
      majority of recipients (79%) understood that there might as well be good reason
      not to opt for a LTx. CONCLUSIONS: LTx recipients appeared at first sight
      'pragmatic' towards the gift of life, but they remained sensitive to its ethical 
      and psychological challenges.
FAU - Ullrich, Gerald
AU  - Ullrich G
AD  - Division of Pediatric Pulmonology, Department of Paediatrics, Hanover Medical
      School, Hanover, Germany. ullrich@med-wiss.com
FAU - Schmidt, Sandra
AU  - Schmidt S
FAU - Scharf, Elfriede
AU  - Scharf E
FAU - Penkert, Jens
AU  - Penkert J
FAU - Niedermeyer, Jost
AU  - Niedermeyer J
FAU - Schulz, Wolfgang
AU  - Schulz W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Disabil Rehabil
JT  - Disability and rehabilitation
JID - 9207179
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Attitude to Health
MH  - Bioethics
MH  - Body Image
MH  - Commodification
MH  - Depersonalization
MH  - Female
MH  - Guilt
MH  - Humans
MH  - Lung Transplantation/ethics/*psychology
MH  - Male
MH  - Retrospective Studies
MH  - Young Adult
EDAT- 2010/03/23 06:00
MHDA- 2010/06/11 06:00
CRDT- 2010/03/23 06:00
PHST- 2010/03/23 06:00 [entrez]
PHST- 2010/03/23 06:00 [pubmed]
PHST- 2010/06/11 06:00 [medline]
AID - 10.3109/09638280903258860 [doi]
PST - ppublish
SO  - Disabil Rehabil. 2010;32(9):713-22. doi: 10.3109/09638280903258860.


PMID- 20301857
OWN - NLM
STAT- MEDLINE
DCOM- 20100409
LR  - 20100322
IS  - 0843-6096 (Print)
VI  - 20
IP  - 1
DP  - 2010
TI  - Duty to warn and genetic disease.
PG  - 12-5
AB  - In this clinical column, we discuss the ambiguous distinction between genetic
      research and clinical genetics, particularly for Mendelian diseases with high
      recurrence risk, high morbidity and/or mortality and the possible amelioration of
      such diseases by screening or treatment. We use arrhythmogenic right ventricular 
      cardiomyopathy as an example of a lethal Mendelian disorder, which prompted the
      discussion contained in this column. Working with such diseases may mean that
      genetic researchers have some responsibility for both immediate research subjects
      and their extended families, as they obtain molecular genetic information. For
      some diseases, therefore, a willingness to accept genetic research results should
      be an inclusion criterion, and it may be considered unethical for research ethics
      boards to approve genetic studies unless measures to ensure clinical follow-up
      have been established. We recommend managing the tensions between genetic
      research and clinical practice by using disease-based genetic registers,
      organized within a clinical genetic service.
FAU - Hodgkinson, Kathy
AU  - Hodgkinson K
AD  - Clinical Epidemiology Unit and Discipline of Genetics, Memorial University of
      Newfoundland, St. John's, NL. khodgkin@mun.ca
FAU - Pullman, Daryl
AU  - Pullman D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Canada
TA  - Can J Cardiovasc Nurs
JT  - Canadian journal of cardiovascular nursing = Journal canadien en soins infirmiers
      cardio-vasculaires
JID - 8913645
MH  - Arrhythmogenic Right Ventricular Dysplasia/diagnosis/epidemiology/*genetics
MH  - Duty to Warn/*ethics
MH  - Ethics Committees, Research/ethics
MH  - Genetic Predisposition to Disease/epidemiology/*genetics
MH  - Genetic Privacy
MH  - Genetic Research/*ethics
MH  - Genetic Services/organization & administration
MH  - Humans
MH  - Newfoundland and Labrador/epidemiology
MH  - Paternalism
MH  - Registries
EDAT- 2010/03/23 06:00
MHDA- 2010/04/10 06:00
CRDT- 2010/03/23 06:00
PHST- 2010/03/23 06:00 [entrez]
PHST- 2010/03/23 06:00 [pubmed]
PHST- 2010/04/10 06:00 [medline]
PST - ppublish
SO  - Can J Cardiovasc Nurs. 2010;20(1):12-5.


PMID- 20213424
OWN - NLM
STAT- MEDLINE
DCOM- 20100623
LR  - 20200324
IS  - 1432-1238 (Electronic)
IS  - 0342-4642 (Linking)
VI  - 36 Suppl 1
DP  - 2010 Apr
TI  - Chapter 9. Educational process. Recommendations and standard operating procedures
      for intensive care unit and hospital preparations for an influenza epidemic or
      mass disaster.
PG  - S70-9
LID - 10.1007/s00134-010-1768-x [doi]
AB  - PURPOSE: To provide recommendations and standard operating procedures (SOPs) for 
      intensive care unit (ICU) and hospital preparations for an influenza pandemic or 
      mass disaster with focus on education of all stakeholders, specifically the
      emergency executive control groups, ICU staff and staff co-opted to assist with
      patient management. METHODS: Based on a literature review and expert opinion, a
      Delphi process was used to define the essential topics, including staff
      education. RESULTS: Key recommendations include: (1) define functional roles and 
      responsibilities of the internal personnel and interface agencies or sectors; (2)
      determine logistic support and requirements necessary for the effective
      implementation of the SOPs; (3) determine what is required to maintain the SOPs; 
      (4) recommended training and activities include: (a) personal protection
      techniques; (b) environmental contamination; (c) medical management; (d)
      laboratory specimens; (e) alert lists; (f) training of recruited staff; (g)
      ethical issues; (h) psychosocial issues; (i) dealing with the deceased; (j)
      policies for restricting visitors; (k) mechanisms for enforcing policies; (5)
      Training should begin as soon as possible with daily demonstrations followed by
      supervised practice; (6) identify the staff to participate in training programs, 
      verify that they have participated and evaluate their knowledge subsequently.
      CONCLUSIONS: Judicious planning and adoption of protocols for staff education are
      necessary to optimize outcomes during a pandemic.
FAU - Richards, Guy A
AU  - Richards GA
AD  - Charlotte Maxeke Johannesburg Hospital, University of the Witwatersrand,
      Johannesburg, South Africa.
FAU - Sprung, Charles L
AU  - Sprung CL
CN  - European Society of Intensive Care Medicine's Task Force for intensive care unit 
      triage during an influenza epidemic or mass disaster
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Intensive Care Med
JT  - Intensive care medicine
JID - 7704851
SB  - IM
MH  - Disaster Planning/methods/*organization & administration/standards
MH  - *Disease Outbreaks
MH  - Disease Transmission, Infectious/prevention & control
MH  - *Emergency Service, Hospital/organization & administration/standards
MH  - Hospital Administration/methods/standards
MH  - Humans
MH  - Infection Control/methods/standards
MH  - Influenza A Virus, H1N1 Subtype
MH  - Influenza, Human/epidemiology/*therapy
MH  - Inservice Training/methods/standards
MH  - *Intensive Care Units/organization & administration/standards
MH  - *Mass Casualty Incidents
MH  - Occupational Health
MH  - Personnel, Hospital/*education/statistics & numerical data
MH  - Safety Management/methods/organization & administration/standards
MH  - Triage
MH  - Workforce
PMC - PMC7080136
IR  - Christian MD
FIR - Christian, Michael D
IR  - Camargo R
FIR - Camargo, Ruben
IR  - Ceraso D
FIR - Ceraso, Daniel
IR  - Azoulay E
FIR - Azoulay, Elie
IR  - Duguet A
FIR - Duguet, Alexandre
IR  - Guery B
FIR - Guery, Benoit
IR  - Reinhart K
FIR - Reinhart, Konrad
IR  - Adini B
FIR - Adini, Bruria
IR  - Barlavie Y
FIR - Barlavie, Yaron
IR  - Benin-Goren O
FIR - Benin-Goren, Odeda
IR  - Cohen R
FIR - Cohen, Robert
IR  - Klein M
FIR - Klein, Motti
IR  - Leoniv Y
FIR - Leoniv, Yuval
IR  - Margalit G
FIR - Margalit, Gila
IR  - Rubinovitch B
FIR - Rubinovitch, Bina
IR  - Sonnenblick M
FIR - Sonnenblick, Moshe
IR  - Sprung CL
FIR - Sprung, Charles L
IR  - Steinberg A
FIR - Steinberg, Avraham
IR  - Weissman C
FIR - Weissman, Charles
IR  - Wolff D
FIR - Wolff, Donna
IR  - Kesecioglu J
FIR - Kesecioglu, Jozef
IR  - de Jong M
FIR - de Jong, Menno
IR  - Moreno R
FIR - Moreno, Rui
IR  - An Y
FIR - An, Youzhong
IR  - Du B
FIR - Du, Bin
IR  - Joynt GM
FIR - Joynt, Gavin M
IR  - Colvin J
FIR - Colvin, John
IR  - Loo S
FIR - Loo, Shi
IR  - Richards G
FIR - Richards, Guy
IR  - Artigas A
FIR - Artigas, Antonio
IR  - Pugin J
FIR - Pugin, Jerome
IR  - Amundson D
FIR - Amundson, Dennis
IR  - Devereaux A
FIR - Devereaux, Asha
IR  - Beigel J
FIR - Beigel, John
IR  - Danis M
FIR - Danis, Marion
IR  - Farmer C
FIR - Farmer, Chris
IR  - Hick JL
FIR - Hick, John L
IR  - Maki D
FIR - Maki, Dennis
IR  - Masur H
FIR - Masur, Henry
IR  - Rubinson L
FIR - Rubinson, Lewis
IR  - Sandrock C
FIR - Sandrock, Christian
IR  - Talmor D
FIR - Talmor, Daniel
IR  - Truog R
FIR - Truog, Robert
IR  - Zimmerman J
FIR - Zimmerman, Janice
IR  - Brett S
FIR - Brett, Steve
IR  - Montgomery H
FIR - Montgomery, Hugh
IR  - Rhodes A
FIR - Rhodes, Andrew
IR  - Sanderson F
FIR - Sanderson, Frances
IR  - Taylor B
FIR - Taylor, Bruce
IR  - Sprung CL
FIR - Sprung, Charles L
IR  - Adini B
FIR - Adini, Bruria
IR  - Azoulay E
FIR - Azoulay, Elie
IR  - Christian MD
FIR - Christian, Michael D
IR  - Cohen R
FIR - Cohen, Robert
IR  - de Jong M
FIR - de Jong, Menno
IR  - Montgomery H
FIR - Montgomery, Hugh
IR  - Rubinson L
FIR - Rubinson, Lewis
IR  - Sandrock C
FIR - Sandrock, Christian
IR  - Sonnenblick M
FIR - Sonnenblick, Moshe
IR  - Talmor D
FIR - Talmor, Daniel
EDAT- 2010/03/23 06:00
MHDA- 2010/06/24 06:00
CRDT- 2010/03/10 06:00
PHST- 2010/03/10 06:00 [entrez]
PHST- 2010/03/23 06:00 [pubmed]
PHST- 2010/06/24 06:00 [medline]
AID - 10.1007/s00134-010-1768-x [doi]
PST - ppublish
SO  - Intensive Care Med. 2010 Apr;36 Suppl 1:S70-9. doi: 10.1007/s00134-010-1768-x.


PMID- 20213422
OWN - NLM
STAT- MEDLINE
DCOM- 20100623
LR  - 20191008
IS  - 1432-1238 (Electronic)
IS  - 0342-4642 (Linking)
VI  - 36 Suppl 1
DP  - 2010 Apr
TI  - Chapter 7. Critical care triage. Recommendations and standard operating
      procedures for intensive care unit and hospital preparations for an influenza
      epidemic or mass disaster.
PG  - S55-64
LID - 10.1007/s00134-010-1765-0 [doi]
AB  - PURPOSE: To provide recommendations and standard operating procedures for
      intensive care unit (ICU) and hospital preparations for an influenza pandemic or 
      mass disaster with a specific focus on critical care triage. METHODS: Based on a 
      literature review and expert opinion, a Delphi process was used to define the
      essential topics including critical care triage. RESULTS: Key recommendations
      include: (1) establish an Incident Management System with Emergency Executive
      Control Groups at facility, local, regional/state or national levels to exercise 
      authority and direction over resources; (2) developing fair and equitable
      policies may require restricting ICU services to patients most likely to benefit;
      (3) usual treatments and standards of practice may be impossible to deliver; (4) 
      ICU care and treatments may have to be withheld from patients likely to die even 
      with ICU care and withdrawn after a trial in patients who do not improve or
      deteriorate; (5) triage criteria should be objective, ethical, transparent,
      applied equitably and be publically disclosed; (6) trigger triage protocols for
      pandemic influenza only when critical care resources across a broad geographic
      area are or will be overwhelmed despite all reasonable efforts to extend
      resources or obtain additional resources; (7) triage of patients for ICU should
      be based on those who are likely to benefit most or a 'first come, first served' 
      basis; (8) a triage officer should apply inclusion and exclusion criteria to
      determine patient qualification for ICU admission. CONCLUSIONS: Judicious
      planning and adoption of protocols for critical care triage are necessary to
      optimize outcomes during a pandemic.
FAU - Christian, Michael D
AU  - Christian MD
AD  - Division of Infectious Diseases and Critical Care, Department of National
      Defence, Canadian Forces, Mount Sinai Hospital, University of Toronto, Toronto,
      Canada.
FAU - Joynt, Gavin M
AU  - Joynt GM
FAU - Hick, John L
AU  - Hick JL
FAU - Colvin, John
AU  - Colvin J
FAU - Danis, Marion
AU  - Danis M
FAU - Sprung, Charles L
AU  - Sprung CL
CN  - European Society of Intensive Care Medicine's Task Force for intensive care unit 
      triage during an influenza epidemic or mass disaster
LA  - eng
GR  - Z99 CL999999/Intramural NIH HHS/United States
PT  - Guideline
PT  - Journal Article
PL  - United States
TA  - Intensive Care Med
JT  - Intensive care medicine
JID - 7704851
SB  - IM
MH  - Critical Care/methods/organization & administration/*standards
MH  - Disaster Planning/methods/organization & administration/*standards
MH  - *Disease Outbreaks
MH  - Emergency Service, Hospital/organization & administration/standards
MH  - Humans
MH  - *Influenza A Virus, H1N1 Subtype
MH  - Influenza, Human/*epidemiology
MH  - Intensive Care Units/organization & administration/*standards
MH  - Mass Casualty Incidents
MH  - Triage/methods/organization & administration/*standards
PMC - PMC4849534
MID - NIHMS772519
IR  - Christian MD
FIR - Christian, Micahel D
IR  - Camargo R
FIR - Camargo, Ruben
IR  - Ceraso D
FIR - Ceraso, Daniel
IR  - Azoulay E
FIR - Azoulay, Elie
IR  - Duguet A
FIR - Duguet, Alexandre
IR  - Guery B
FIR - Guery, Benoit
IR  - Reinhart K
FIR - Reinhart, Konrad
IR  - Adini B
FIR - Adini, Bruria
IR  - Barlavie Y
FIR - Barlavie, Yaron
IR  - Benin-Goren O
FIR - Benin-Goren, Odeda
IR  - Cohen R
FIR - Cohen, Robert
IR  - Klein M
FIR - Klein, Motti
IR  - Leoniv Y
FIR - Leoniv, Yuval
IR  - Margalit G
FIR - Margalit, Gila
IR  - Rubinovitch B
FIR - Rubinovitch, Bina
IR  - Sonnenblick M
FIR - Sonnenblick, Moshe
IR  - Sprung CL
FIR - Sprung, Charles L
IR  - Steinberg A
FIR - Steinberg, Avraham
IR  - Weissman C
FIR - Weissman, Charles
IR  - Wolff D
FIR - Wolff, Donna
IR  - Kesecioglu J
FIR - Kesecioglu, Jozef
IR  - de Jong M
FIR - de Jong, Menno
IR  - Moreno R
FIR - Moreno, Rui
IR  - An Y
FIR - An, Youzhong
IR  - Du B
FIR - Du, Bin
IR  - Joynt GM
FIR - Joynt, Gavin M
IR  - Colvin J
FIR - Colvin, John
IR  - Loo S
FIR - Loo, Shi
IR  - Richards G
FIR - Richards, Guy
IR  - Artigas A
FIR - Artigas, Antonio
IR  - Pugin J
FIR - Pugin, Jerome
IR  - Amundson D
FIR - Amundson, Dennis
IR  - Devereaux A
FIR - Devereaux, Asha
IR  - Beigel J
FIR - Beigel, John
IR  - Danis M
FIR - Danis, Marion
IR  - Farmer C
FIR - Farmer, Chris
IR  - Hick JL
FIR - Hick, John L
IR  - Maki D
FIR - Maki, Dennis
IR  - Masur H
FIR - Masur, Henry
IR  - Rubinson L
FIR - Rubinson, Lewis
IR  - Sandrock C
FIR - Sandrock, Christian
IR  - Talmor D
FIR - Talmor, Daniel
IR  - Truog R
FIR - Truog, Robert
IR  - Zimmerman J
FIR - Zimmerman, Janice
IR  - Brett S
FIR - Brett, Steve
IR  - Montgomery H
FIR - Montgomery, Hugh
IR  - Rhodes A
FIR - Rhodes, Andrew
IR  - Sanderson F
FIR - Sanderson, Frances
IR  - Taylor B
FIR - Taylor, Bruce
IR  - Sprung CL
FIR - Sprung, Charles L
IR  - Adini B
FIR - Adini, Bruria
IR  - Azoulay E
FIR - Azoulay, Elie
IR  - Christian MD
FIR - Christian, Michael D
IR  - Cohen R
FIR - Cohen, Robert
IR  - de Jong M
FIR - de Jong, Menno
IR  - Montgomery H
FIR - Montgomery, Hugh
IR  - Rubinson L
FIR - Rubinson, Lewis
IR  - Sandrock C
FIR - Sandrock, Christian
IR  - Sonnenblick M
FIR - Sonnenblick, Moshe
IR  - Talmor D
FIR - Talmor, Daniel
EDAT- 2010/03/23 06:00
MHDA- 2010/06/24 06:00
CRDT- 2010/03/10 06:00
PHST- 2010/03/10 06:00 [entrez]
PHST- 2010/03/23 06:00 [pubmed]
PHST- 2010/06/24 06:00 [medline]
AID - 10.1007/s00134-010-1765-0 [doi]
PST - ppublish
SO  - Intensive Care Med. 2010 Apr;36 Suppl 1:S55-64. doi: 10.1007/s00134-010-1765-0.


PMID- 20300419
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 0974-8245 (Electronic)
IS  - 0974-777X (Linking)
VI  - 2
IP  - 1
DP  - 2010 Jan
TI  - Oral sex, oral health and orogenital infections.
PG  - 57-62
LID - 10.4103/0974-777X.59252 [doi]
AB  - Oral sex is commonly practiced by sexually active male-female and same-gender
      couples of various ages, including adolescents. The various type of oral sex
      practices are fellatio, cunnilingus and analingus. Oral sex is infrequently
      examined in research on adolescents; oral sex can transmit oral, respiratory, and
      genital pathogens. Oral health has a direct impact on the transmission of
      infection; a cut in your mouth, bleeding gums, lip sores or broken skin increases
      chances of infection. Although oral sex is considered a low risk activity, it is 
      important to use protection and safer sex precautions. There are various methods 
      of preventing infection during oral sex such as physical barriers, health and
      medical issues, ethical issues and oral hygiene and dental issues. The lesions or
      unhealthy periodontal status of oral cavity accelerates the phenomenon of
      transmission of infections into the circulation. Thus consequences of unhealthy
      or painful oral cavity are significant and oral health should be given paramount 
      importance for the practice of oral sex.
FAU - Saini, Rajiv
AU  - Saini R
AD  - Departments of Periodontology & Oral Implantology, Rural Dental College,
      Maharashtra, India.
FAU - Saini, Santosh
AU  - Saini S
FAU - Sharma, Sugandha
AU  - Sharma S
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Glob Infect Dis
JT  - Journal of global infectious diseases
JID - 101521436
PMC - PMC2840968
OTO - NOTNLM
OT  - Oral Health
OT  - Oral Sex
OT  - Orogenital
EDAT- 2010/03/20 06:00
MHDA- 2010/03/20 06:01
CRDT- 2010/03/20 06:00
PHST- 2010/03/20 06:00 [entrez]
PHST- 2010/03/20 06:00 [pubmed]
PHST- 2010/03/20 06:01 [medline]
AID - 10.4103/0974-777X.59252 [doi]
PST - ppublish
SO  - J Glob Infect Dis. 2010 Jan;2(1):57-62. doi: 10.4103/0974-777X.59252.


PMID- 20299042
OWN - NLM
STAT- MEDLINE
DCOM- 20100506
LR  - 20100412
IS  - 1527-3792 (Electronic)
IS  - 0022-5347 (Linking)
VI  - 183
IP  - 5
DP  - 2010 May
TI  - Marker lesion experiments in bladder cancer--what have we learned?
PG  - 1678-84
LID - 10.1016/j.juro.2009.12.104 [doi]
AB  - PURPOSE: In marker lesion experiments a single bladder tumor is deliberately left
      unresected for later ablation by intravesical instillation of a novel agent.
      While the benefits are clear, eg the opportunity to examine the effect of therapy
      on measurable disease, the safety and medical ethics of these experiments are
      less obvious. We review the goals, inclusion criteria, definition of success,
      agents used, effectiveness, safety and ethics of marker lesion studies, and
      suggest a framework for future experiments. MATERIALS AND METHODS: Published
      bladder cancer studies using the marker lesion concept were identified with a
      MEDLINE search through March 2009. RESULTS: A total of 23 well documented marker 
      lesion studies were identified involving more than 1,200 patients. Most agents
      studied were cytotoxins (mitomycin-C, epirubicin, gemcitabine, valrubicin,
      apaziquone) or immune response modifiers (bacillus Calmette-Guerin, tumor
      necrosis factor-alpha, interferon-alpha, granulocyte-macrophage
      colony-stimulating factor). The highest complete response rate in intermediate
      risk patients (67%) was attained with apaziquone. Patients who achieved a
      complete response with this agent also had a prophylactic benefit with a 2-year
      recurrence-free rate of 45.2% compared to 26.7% in those who did not achieve a
      complete response. The complete response rate in bacillus Calmette-Guerin trials 
      ranged from 32% to 61%. Marker lesion experiments were deemed safe with
      progression to T2 disease in only 7 patients (0.6%) and only when high risk
      patients were selected. CONCLUSIONS: Marker lesion studies are most appropriate
      for the evaluation of novel anticancer therapeutics. Only patients with multiple 
      recurrent, noninvasive, low grade tumors (intermediate risk) should be recruited.
      Primary end points should be complete response and recurrence rates after 2 to 3 
      years.
CI  - 2010 American Urological Association Education and Research, Inc. Published by
      Elsevier Inc. All rights reserved.
FAU - Gofrit, Ofer N
AU  - Gofrit ON
AD  - Department of Urology, Hadassah Hebrew University Hospital, Jerusalem, Israel.
      ogofrit@gmail.com
FAU - Zorn, Kevin C
AU  - Zorn KC
FAU - Shikanov, Sergey
AU  - Shikanov S
FAU - Steinberg, Gary D
AU  - Steinberg GD
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100317
PL  - United States
TA  - J Urol
JT  - The Journal of urology
JID - 0376374
RN  - 0 (Antineoplastic Agents)
SB  - IM
CIN - J Urol. 2010 May;183(5):1667-8. PMID: 20299061
CIN - J Urol. 2010 May;183(5):1685. PMID: 20299063
MH  - Administration, Intravesical
MH  - Antineoplastic Agents/*administration & dosage
MH  - Catheter Ablation
MH  - Humans
MH  - Urinary Bladder Neoplasms/*drug therapy/pathology/surgery
RF  - 30
EDAT- 2010/03/20 06:00
MHDA- 2010/05/07 06:00
CRDT- 2010/03/20 06:00
PHST- 2009/07/04 00:00 [received]
PHST- 2010/03/20 06:00 [entrez]
PHST- 2010/03/20 06:00 [pubmed]
PHST- 2010/05/07 06:00 [medline]
AID - S0022-5347(09)03403-X [pii]
AID - 10.1016/j.juro.2009.12.104 [doi]
PST - ppublish
SO  - J Urol. 2010 May;183(5):1678-84. doi: 10.1016/j.juro.2009.12.104. Epub 2010 Mar
      17.


PMID- 20298974
OWN - NLM
STAT- MEDLINE
DCOM- 20100729
LR  - 20100319
IS  - 1552-5279 (Electronic)
IS  - 1552-5260 (Linking)
VI  - 6
IP  - 2
DP  - 2010 Mar
TI  - Commentary on "Developing a national strategy to prevent dementia: Leon Thal
      Symposium 2009." The rationale for a National Institutional Review Board for
      neurodegenerative diseases.
PG  - 135-7
LID - 10.1016/j.jalz.2010.01.007 [doi]
AB  - The published proceedings of the second Annual Leon Thal Symposium (Alzheimers
      Dement 2009;5:85-92) have added to the open discussion among leaders in this
      field, with respect to the development of a national strategy for accelerating
      the discovery of preventative interventions for Alzheimer's disease. One of the
      recommended "action steps" detailed in that report centers on the establishment
      of a National Institutional Review Board for neurodegenerative diseases. The
      purpose of this new ethical oversight panel would be to increase the efficiency
      with which large-scale multi-site trials are conducted. This essay expands on
      this recommendation, and two potential organizational models are briefly
      considered. A well-designed, highly-qualified, and responsive National
      Institutional Review Board for neurodegenerative diseases would serve the direct 
      interest of protecting the rights, welfare, and safety of our older citizens, who
      so generously contribute their time, energy, and comfort to advance research to
      discover new treatments for this devastating disease.
CI  - 2010 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
FAU - Snyder, Peter J
AU  - Snyder PJ
AD  - Department of Neurology, Alpert Medical School of Brown University, Providence,
      RI, USA. psnyder@lifespan.org
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Alzheimers Dement
JT  - Alzheimer's & dementia : the journal of the Alzheimer's Association
JID - 101231978
SB  - IM
CON - Alzheimers Dement. 2010 Mar;6(2):89-97. PMID: 20298968
MH  - Aged
MH  - Alzheimer Disease/*diagnosis/drug therapy/*prevention & control
MH  - Clinical Trials Data Monitoring Committees/*standards
MH  - Clinical Trials as Topic/*ethics/*standards
MH  - Ethics Committees, Research/*standards
MH  - Ethics, Medical
MH  - Health Policy/*legislation & jurisprudence
MH  - Humans
MH  - Informed Consent
MH  - Neurodegenerative Diseases/*diagnosis/drug therapy/*prevention & control
MH  - Patient Selection
MH  - Research Design
EDAT- 2010/03/20 06:00
MHDA- 2010/07/30 06:00
CRDT- 2010/03/20 06:00
PHST- 2009/12/30 00:00 [received]
PHST- 2010/01/11 00:00 [accepted]
PHST- 2010/03/20 06:00 [entrez]
PHST- 2010/03/20 06:00 [pubmed]
PHST- 2010/07/30 06:00 [medline]
AID - S1552-5260(10)00012-9 [pii]
AID - 10.1016/j.jalz.2010.01.007 [doi]
PST - ppublish
SO  - Alzheimers Dement. 2010 Mar;6(2):135-7. doi: 10.1016/j.jalz.2010.01.007.


PMID- 20297761
OWN - NLM
STAT- MEDLINE
DCOM- 20100402
LR  - 20181113
IS  - 0033-3549 (Print)
IS  - 0033-3549 (Linking)
VI  - 125
IP  - 2
DP  - 2010 Mar-Apr
TI  - Improving the lives of vulnerable children: implications of Horizons research
      among orphans and other children affected by AIDS.
PG  - 325-36
AB  - From 1997 through 2007, the Horizons program conducted research to inform the
      care and support of children who had been orphaned and rendered vulnerable by
      acquired immunodeficiency syndrome in sub-Saharan Africa. Horizons conducted
      studies in Kenya, Malawi, Rwanda, South Africa, Uganda, Zambia, and Zimbabwe.
      Research included both diagnostic studies exploring the circumstances of families
      and communities affected by human immunodeficiency virus (HIV) and evaluations of
      pioneering intervention strategies. Interventions found to be supportive of
      families included succession planning for families with an HIV-positive parent,
      training and supporting youth as caregivers, and youth mentorship for
      child-headed households. Horizons researchers developed tools to assess the
      psychosocial well-being of children affected by HIV and outlined key ethical
      guidelines for conducting research among children. The design, implementation,
      and evaluation of community-based interventions for orphans and vulnerable
      children continue to be a key gap in the evidence base.
FAU - Schenk, Katie D
AU  - Schenk KD
AD  - Population Council, Washington, DC 20008, USA. kschenk@popcouncil.org
FAU - Michaelis, Annie
AU  - Michaelis A
FAU - Sapiano, Tobey Nelson
AU  - Sapiano TN
FAU - Brown, Lisanne
AU  - Brown L
FAU - Weiss, Ellen
AU  - Weiss E
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Public Health Rep
JT  - Public health reports (Washington, D.C. : 1974)
JID - 9716844
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/ethnology/prevention & control/*psychology
MH  - Africa South of the Sahara/epidemiology
MH  - Child
MH  - *Child Advocacy
MH  - Child Health Services/organization & administration
MH  - *Child, Orphaned/statistics & numerical data
MH  - Community Health Services/organization & administration
MH  - Cost of Illness
MH  - Guidelines as Topic
MH  - Health Planning Support
MH  - Health Services Needs and Demand
MH  - Humans
MH  - Patient Selection/ethics
MH  - Program Development
MH  - Program Evaluation
MH  - Psychology, Child
MH  - Quality of Life/*psychology
MH  - Social Support
MH  - *Vulnerable Populations/ethnology/statistics & numerical data
PMC - PMC2821862
EDAT- 2010/03/20 06:00
MHDA- 2010/04/03 06:00
CRDT- 2010/03/20 06:00
PHST- 2010/03/20 06:00 [entrez]
PHST- 2010/03/20 06:00 [pubmed]
PHST- 2010/04/03 06:00 [medline]
AID - 10.1177/003335491012500223 [doi]
PST - ppublish
SO  - Public Health Rep. 2010 Mar-Apr;125(2):325-36. doi: 10.1177/003335491012500223.


PMID- 20238101
OWN - NLM
STAT- MEDLINE
DCOM- 20110211
LR  - 20181113
IS  - 1433-2965 (Electronic)
IS  - 0937-941X (Linking)
VI  - 21
IP  - 5
DP  - 2010 May
TI  - The need for a transparent, ethical, and successful relationship between academic
      scientists and the pharmaceutical industry: a view of the Group for the Respect
      of Ethics and Excellence in Science (GREES).
PG  - 713-22
LID - 10.1007/s00198-010-1190-9 [doi]
AB  - UNLABELLED: This paper provides recommendations for fair and unbiased
      relationship between academic scientists and the pharmaceutical industry.
      INTRODUCTION: Real or perceived problems in the relationship between academics
      and the industry have been the subject of much recent debate. It has been
      suggested that academic clinicians should sever all links with the industry-a
      view that is rarely challenged. METHODS: Academic experts and members of the
      pharmaceutical industry were invited to an expert consensus meeting to debate
      this topic. This meeting was organized by the Group for the Respect of Ethics and
      Excellence in Science. Conflict of interest, competing interest, right and duties
      of academic scientist, authorship, and staff and student education were
      discussed. RESULTS: Guidelines for a transparent, ethical, strong, and successful
      partnership between the academic scientist and the pharmaceutical industry have
      been provided. CONCLUSIONS: The Group support interactions between the industry
      and clinicians provided that it is transparent and ethical.
FAU - Bruyere, O
AU  - Bruyere O
AD  - Department of Public Health, Epidemiology and Health Economics, University of
      Liege, Liege, Belgium. oliver.bruyere@ulg.ac.be
FAU - Kanis, J A
AU  - Kanis JA
FAU - Ibar-Abadie, M-E
AU  - Ibar-Abadie ME
FAU - Alsayed, N
AU  - Alsayed N
FAU - Brandi, M L
AU  - Brandi ML
FAU - Burlet, N
AU  - Burlet N
FAU - Cahall, D L
AU  - Cahall DL
FAU - Chines, A
AU  - Chines A
FAU - Devogelaer, J-P
AU  - Devogelaer JP
FAU - Dere, W
AU  - Dere W
FAU - Goel, N
AU  - Goel N
FAU - Hughes, N
AU  - Hughes N
FAU - Kaufman, J-M
AU  - Kaufman JM
FAU - Korte, S
AU  - Korte S
FAU - Mitlak, B H
AU  - Mitlak BH
FAU - Niese, D
AU  - Niese D
FAU - Rizzoli, R
AU  - Rizzoli R
FAU - Rovati, L C
AU  - Rovati LC
FAU - Reginster, J-Y
AU  - Reginster JY
LA  - eng
PT  - Consensus Development Conference
PT  - Journal Article
DEP - 20100318
PL  - England
TA  - Osteoporos Int
JT  - Osteoporosis international : a journal established as result of cooperation
      between the European Foundation for Osteoporosis and the National Osteoporosis
      Foundation of the USA
JID - 9100105
SB  - IM
MH  - Authorship
MH  - Conflict of Interest
MH  - Disclosure/*ethics
MH  - Drug Industry/*ethics
MH  - Education, Medical/methods
MH  - Ethics, Research/education
MH  - Humans
MH  - *Interinstitutional Relations
MH  - Schools, Medical/ethics
MH  - Trust
EDAT- 2010/03/20 06:00
MHDA- 2011/02/12 06:00
CRDT- 2010/03/19 06:00
PHST- 2009/12/18 00:00 [received]
PHST- 2010/01/27 00:00 [accepted]
PHST- 2010/03/19 06:00 [entrez]
PHST- 2010/03/20 06:00 [pubmed]
PHST- 2011/02/12 06:00 [medline]
AID - 10.1007/s00198-010-1190-9 [doi]
PST - ppublish
SO  - Osteoporos Int. 2010 May;21(5):713-22. doi: 10.1007/s00198-010-1190-9. Epub 2010 
      Mar 18.


PMID- 20237903
OWN - NLM
STAT- MEDLINE
DCOM- 20140522
LR  - 20101015
IS  - 0724-6145 (Print)
IS  - 0724-6145 (Linking)
VI  - 123
DP  - 2010
TI  - Alternative sources of adult stem cells: human amniotic membrane.
PG  - 1-27
LID - 10.1007/10_2010_71 [doi]
AB  - Human amniotic membrane is a highly promising cell source for tissue engineering.
      The cells thereof, human amniotic epithelial cells (hAEC) and human amniotic
      mesenchymal stromal cells (hAMSC), may be immunoprivileged, they represent an
      early developmental status, and their application is ethically uncontroversial.
      Cell banking strategies may use freshly isolated cells or involve in vitro
      expansion to increase cell numbers. Therefore, we have thoroughly characterized
      the effect of in vitro cultivation on both phenotype and differentiation
      potential of hAEC. Moreover, we present different strategies to improve expansion
      including replacement of animal-derived supplements by human platelet products or
      the introduction of the catalytic subunit of human telomerase to extend the in
      vitro lifespan of amniotic cells. Characterization of the resulting cultures
      includes phenotype, growth characteristics, and differentiation potential, as
      well as immunogenic and immunomodulatory properties.
FAU - Wolbank, Susanne
AU  - Wolbank S
AD  - Ludwig Boltzmann Institute for Experimental and Clinical Traumatology,
      Donaueschingenstrasse 13, 1200 Vienna, Austria.
FAU - van Griensven, Martijn
AU  - van Griensven M
FAU - Grillari-Voglauer, Regina
AU  - Grillari-Voglauer R
FAU - Peterbauer-Scherb, Anja
AU  - Peterbauer-Scherb A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Adv Biochem Eng Biotechnol
JT  - Advances in biochemical engineering/biotechnology
JID - 8307733
SB  - IM
MH  - Adult Stem Cells/*cytology/*physiology
MH  - Amnion/*cytology/*physiology
MH  - Cell Culture Techniques/*methods
MH  - Cell Differentiation/physiology
MH  - Cell Proliferation
MH  - Cell Separation/*methods
MH  - Cells, Cultured
MH  - Humans
MH  - Tissue Engineering/*methods
EDAT- 2010/03/20 06:00
MHDA- 2014/05/23 06:00
CRDT- 2010/03/19 06:00
PHST- 2010/03/19 06:00 [entrez]
PHST- 2010/03/20 06:00 [pubmed]
PHST- 2014/05/23 06:00 [medline]
AID - 10.1007/10_2010_71 [doi]
PST - ppublish
SO  - Adv Biochem Eng Biotechnol. 2010;123:1-27. doi: 10.1007/10_2010_71.


PMID- 20237854
OWN - NLM
STAT- MEDLINE
DCOM- 20100421
LR  - 20181113
IS  - 1573-0980 (Electronic)
IS  - 1386-7415 (Linking)
VI  - 31
IP  - 1
DP  - 2010 Feb
TI  - Schizophrenia, mental capacity, and rational suicide.
PG  - 63-77
LID - 10.1007/s11017-010-9137-x [doi]
AB  - A diagnosis of schizophrenia is often taken to denote a state of global
      irrationality within the psychiatric paradigm, wherein psychotic phenomena are
      seen to equate with a lack of mental capacity. However, the little research that 
      has been undertaken on mental capacity in psychiatric patients shows that people 
      with schizophrenia are more likely to experience isolated, rather than
      constitutive, irrationality and are therefore not necessarily globally
      incapacitated. Rational suicide has not been accepted as a valid choice for
      people with schizophrenia due in part to a belief that characteristic
      irrationality prevents autonomous decision-making. Since people with
      schizophrenia are often seen to lack insight into the nature of their disorder,
      both psychiatric and ethical perspectives generally presume that suicidal acts
      result directly from mental illness itself and not from second-order desires. In 
      this article, I challenge notions of global irrationality conferred by a
      diagnosis of schizophrenia and argue that, where delusional beliefs are unifocal,
      schizophrenia does not necessarily lead to a state of mental incapacity. I then
      attempt to show that people with schizophrenia can sometimes be rational with
      regard to suicide, where this decision stems from a realistic appraisal of
      psychological suffering.
FAU - Hewitt, Jeanette
AU  - Hewitt J
AD  - Department of Philosophy, History and Law, School of Human and Health Sciences,
      Swansea University, Singleton Park, Swansea, SA2 8PP, UK. j.l.hewitt@swan.ac.uk
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Theor Med Bioeth
JT  - Theoretical medicine and bioethics
JID - 9805378
SB  - IM
MH  - *Choice Behavior
MH  - *Cognition
MH  - Decision Making
MH  - Humans
MH  - Internal-External Control
MH  - Interpersonal Relations
MH  - Mental Competency/*legislation & jurisprudence
MH  - Mental Disorders/psychology
MH  - *Personal Autonomy
MH  - Quality of Life
MH  - Schizophrenia/*diagnosis
MH  - *Schizophrenic Psychology
MH  - Stress, Psychological/*psychology
MH  - Suicide/prevention & control/*psychology
MH  - Treatment Refusal/psychology
MH  - United Kingdom
EDAT- 2010/03/20 06:00
MHDA- 2010/04/22 06:00
CRDT- 2010/03/19 06:00
PHST- 2010/03/19 06:00 [entrez]
PHST- 2010/03/20 06:00 [pubmed]
PHST- 2010/04/22 06:00 [medline]
AID - 10.1007/s11017-010-9137-x [doi]
PST - ppublish
SO  - Theor Med Bioeth. 2010 Feb;31(1):63-77. doi: 10.1007/s11017-010-9137-x.


PMID- 20237853
OWN - NLM
STAT- MEDLINE
DCOM- 20100421
LR  - 20220330
IS  - 1573-0980 (Electronic)
IS  - 1386-7415 (Linking)
VI  - 31
IP  - 1
DP  - 2010 Feb
TI  - Madness versus badness: the ethical tension between the recovery movement and
      forensic psychiatry.
PG  - 93-105
LID - 10.1007/s11017-010-9138-9 [doi]
AB  - The mental health recovery movement promotes patient self-determination and
      opposes coercive psychiatric treatment. While it has made great strides towards
      these ends, its rhetoric impairs its political efficacy. We illustrate how
      psychiatry can share recovery values and yet appear to violate them. In certain
      criminal proceedings, for example, forensic psychiatrists routinely argue that
      persons with mental illness who have committed crimes are not full moral agents. 
      Such arguments align with the recovery movement's aim of providing appropriate
      treatment and services for people with severe mental illness, but contradict its 
      fundamental principle of self-determination. We suggest that this contradiction
      should be addressed with some urgency, and we recommend a multidisciplinary
      collaborative effort involving ethics, law, psychiatry, and social policy to
      address this and other ethical questions that arise as the United States strives 
      to implement recovery-oriented programs.
FAU - Pouncey, Claire L
AU  - Pouncey CL
AD  - Center for Bioethics, University of Pennsylvania, 3401 Market Street, Suite 320, 
      Philadelphia, PA 19104-3308, USA. pouncey@mail.med.upenn.edu
FAU - Lukens, Jonathan M
AU  - Lukens JM
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Theor Med Bioeth
JT  - Theoretical medicine and bioethics
JID - 9805378
SB  - IM
MH  - Beneficence
MH  - *Bioethics
MH  - *Character
MH  - Commitment of Mentally Ill/legislation & jurisprudence/standards/trends
MH  - Community Mental Health Services
MH  - *Community Psychiatry/standards/trends
MH  - Criminals/*psychology
MH  - *Dangerous Behavior
MH  - Decision Making
MH  - *Forensic Psychiatry/standards/trends
MH  - Humans
MH  - Interdisciplinary Communication
MH  - Jurisprudence
MH  - Knowledge
MH  - Mental Competency
MH  - Mental Disorders/*psychology/*rehabilitation
MH  - *Morals
MH  - Patient Advocacy
MH  - *Personal Autonomy
MH  - Physician-Patient Relations/ethics
MH  - Public Policy/legislation & jurisprudence/trends
MH  - Punishment
MH  - Recovery of Function
MH  - Self-Help Groups
MH  - Social Values
MH  - Terminology as Topic
MH  - United States
EDAT- 2010/03/20 06:00
MHDA- 2010/04/22 06:00
CRDT- 2010/03/19 06:00
PHST- 2010/03/19 06:00 [entrez]
PHST- 2010/03/20 06:00 [pubmed]
PHST- 2010/04/22 06:00 [medline]
AID - 10.1007/s11017-010-9138-9 [doi]
PST - ppublish
SO  - Theor Med Bioeth. 2010 Feb;31(1):93-105. doi: 10.1007/s11017-010-9138-9.


PMID- 20237804
OWN - NLM
STAT- MEDLINE
DCOM- 20101102
LR  - 20181113
IS  - 1432-2218 (Electronic)
IS  - 0930-2794 (Linking)
VI  - 24
IP  - 8
DP  - 2010 Aug
TI  - Minimally invasive fetoscopic interventions: an overview in 2010.
PG  - 2056-67
LID - 10.1007/s00464-010-0879-3 [doi]
AB  - BACKGROUND: The availability of high-end endoscopic equipment, microcatheters,
      miniballoons, tiny laser fibers, and other devices has been instrumental in the
      development of minimally invasive fetoscopic interventions. These interventions
      are performed for a spectrum of fetal disease states that progress in severity
      over the course of gestation and have a huge impact on termination of pregnancy
      rates, fetal demise, perinatal mortality and morbidity, and long-term prognosis. 
      This report aims to introduce interested readers to these new procedures.
      METHODS: Fetoscopic interventions such as laser coagulation of pathologic
      placental vascular connections in twin-to-twin-transfusion-syndrome, fetal
      biopsies, fetal tracheal balloon occlusion in diaphragmatic hernia, perforation
      of posterior urethral valves, tracheal decompression in fetal laryngeal atresia, 
      and even coverage of spina bifida aperta can be performed by percutaneous
      minimally invasive fetoscopic techniques. RESULTS: In contrast to prenatally
      untreated patients, the majority of patients who underwent fetoscopic
      interventions followed by state-of-the-art neonatal intensive care experienced
      improved survival rates and enhanced quality of life. Yet for some patients,
      significant morbidity from the underlying disease or fetal surgical
      complications, most often early preterm delivery, persist in postnatal life.
      CONCLUSION: A growing spectrum of fetal disease states has become amenable to
      minimally invasive fetoscopic interventions. Sufficient training, an
      interdisciplinary approach, ethical board supervision, and continued scientific
      assessment of benefits and risks are important for the success and acceptance of 
      these procedures. Further improvements in fetal selection, surgical techniques,
      and postnatal management accompanied by the development of specialized devices
      are desired.
FAU - Kohl, Thomas
AU  - Kohl T
AD  - Department of Obstetrics and Prenatal Medicine, German Center for Fetal Surgery
      and Minimally Invasive Therapy, University of Bonn, Sigmund Freud Strasse 25,
      53105 Bonn, Germany. thomas.kohl@ukb.uni-bonn.de
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100317
PL  - Germany
TA  - Surg Endosc
JT  - Surgical endoscopy
JID - 8806653
SB  - IM
MH  - Fetal Diseases/*surgery
MH  - Fetoscopy/*methods
MH  - Humans
EDAT- 2010/03/20 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/03/19 06:00
PHST- 2009/04/21 00:00 [received]
PHST- 2009/08/14 00:00 [accepted]
PHST- 2010/03/19 06:00 [entrez]
PHST- 2010/03/20 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - 10.1007/s00464-010-0879-3 [doi]
PST - ppublish
SO  - Surg Endosc. 2010 Aug;24(8):2056-67. doi: 10.1007/s00464-010-0879-3. Epub 2010
      Mar 17.


PMID- 20237307
OWN - NLM
STAT- MEDLINE
DCOM- 20100608
LR  - 20151119
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Linking)
VI  - 74
IP  - 16
DP  - 2010 Apr 20
TI  - Sedation for the imminently dying: survey results from the AAN Ethics Section.
PG  - 1303-9
LID - 10.1212/WNL.0b013e3181d9edcb [doi]
AB  - OBJECTIVES: Sedation for the imminently dying (SFTID) is a controversial practice
      that involves the provision of sedation to imminently dying patients with the
      intent of relieving their suffering when symptoms are refractory to other
      interventions. The goal of this research was to ascertain the opinions regarding 
      SFTID that are held by neurologists who are interested in ethics and end-of-life 
      care. METHODS: Members of the American Academy of Neurology Ethics Section were
      surveyed regarding their familiarity and experience with SFTID and their opinions
      pertaining to it. To determine whether their opinions varied in relationship to
      clinical context, a single stem question for 5 different case scenarios was used.
      RESULTS: A total of 96% of respondents agreed or strongly agreed that the primary
      purpose of SFTID was to relieve suffering, 83% disagreed or strongly disagreed
      that SFTID was morally equivalent to euthanasia, and 85% disagreed or strongly
      disagreed that SFTID was legally equivalent to euthanasia. For the case
      scenarios, 92% agreed or strongly agreed that SFTID was acceptable for imminently
      dying patients with metastatic cancer, while 50% agreed or strongly agreed that
      SFTID was acceptable for patients with end-stage amyotrophic lateral sclerosis,
      and only 7% agreed or strongly agreed that SFTID was acceptable for posttraumatic
      quadriplegic patients not at risk for imminent death. CONCLUSIONS: The
      overwhelming majority of neurologists surveyed endorse the concept that sedation 
      for the imminently dying differs morally and legally from euthanasia and that it 
      is an acceptable therapeutic option for some but not all patients who are
      imminently dying of a terminal illness.
FAU - Russell, James A
AU  - Russell JA
AD  - Department of Neurology, Lahey Clinic, Burlington, MA 01805, USA.
      james.a.russell@lahey.org
FAU - Williams, Michael A
AU  - Williams MA
FAU - Drogan, Oksana
AU  - Drogan O
LA  - eng
PT  - Journal Article
DEP - 20100317
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
SB  - IM
CIN - Neurology. 2010 Nov 9;75(19):1753; author reply 1753-4. PMID: 21060101
MH  - Amyotrophic Lateral Sclerosis/complications
MH  - Attitude of Health Personnel
MH  - Attitude to Death
MH  - Conscious Sedation/*ethics/standards
MH  - Culture
MH  - Data Collection
MH  - Decision Making/ethics
MH  - Ethics, Medical
MH  - Euthanasia/ethics
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Neoplasms/complications
MH  - Neurology/*ethics/standards
MH  - Pain, Intractable/*drug therapy/prevention & control
MH  - Palliative Care/*ethics/methods/standards
MH  - Physician's Role
MH  - Physician-Patient Relations/ethics
MH  - Practice Patterns, Physicians'/*ethics/standards/statistics & numerical data
MH  - Quadriplegia/complications
MH  - Quality of Life
MH  - Right to Die/ethics
MH  - Societies, Medical/ethics/standards
MH  - Stress, Psychological/drug therapy/prevention & control
MH  - *Terminally Ill
EDAT- 2010/03/20 06:00
MHDA- 2010/06/09 06:00
CRDT- 2010/03/19 06:00
PHST- 2010/03/19 06:00 [entrez]
PHST- 2010/03/20 06:00 [pubmed]
PHST- 2010/06/09 06:00 [medline]
AID - WNL.0b013e3181d9edcb [pii]
AID - 10.1212/WNL.0b013e3181d9edcb [doi]
PST - ppublish
SO  - Neurology. 2010 Apr 20;74(16):1303-9. doi: 10.1212/WNL.0b013e3181d9edcb. Epub
      2010 Mar 17.


PMID- 20236869
OWN - NLM
STAT- MEDLINE
DCOM- 20100722
LR  - 20100426
IS  - 1525-5069 (Electronic)
IS  - 1525-5050 (Linking)
VI  - 17
IP  - 4
DP  - 2010 Apr
TI  - The effective and ethical use of voluntary induction of psychogenic drop attacks 
      in a patient with idiopathic generalized epilepsy.
PG  - 569-70
LID - 10.1016/j.yebeh.2010.02.001 [doi]
AB  - A woman known to have never fully controlled idiopathic generalized epilepsy
      presented at 47 years of age with a new onset of drop attacks. After clinical
      investigations, including prolonged video/EEG telemetry, tilt-table testing, and 
      multiple sleep latency tests, the etiology of her drop attacks remained elusive. 
      Subsequently we were able to demonstrate that her drop attacks may be provoked by
      her voluntary recollection of memories of past sexual abuse. This case study
      highlights the need to consider psychological factors when evaluating otherwise
      unexplained drop attacks. In addition, we propose a seizure-provoking technique
      that may be used both effectively and ethically in the diagnosis of psychogenic
      drop attacks as well as nonepileptic seizures.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Wilner, Asher
AU  - Wilner A
AD  - McGill University Health Centre, Consultation Liaison Service, Department of
      Psychiatry, Allan Memorial Institute, Montreal, Quebec, Canada.
      asher.wilner@mcgill.ca
FAU - Keezer, Mark R
AU  - Keezer MR
FAU - Andermann, Frederick
AU  - Andermann F
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20100316
PL  - United States
TA  - Epilepsy Behav
JT  - Epilepsy & behavior : E&B
JID - 100892858
SB  - IM
MH  - Electroencephalography
MH  - Epilepsy, Generalized/*complications
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Psychophysiologic Disorders/complications/psychology
MH  - Syncope/*etiology/*psychology/therapy
MH  - Video Recording
EDAT- 2010/03/20 06:00
MHDA- 2010/07/23 06:00
CRDT- 2010/03/19 06:00
PHST- 2010/01/22 00:00 [received]
PHST- 2010/02/03 00:00 [revised]
PHST- 2010/02/04 00:00 [accepted]
PHST- 2010/03/19 06:00 [entrez]
PHST- 2010/03/20 06:00 [pubmed]
PHST- 2010/07/23 06:00 [medline]
AID - S1525-5050(10)00205-2 [pii]
AID - 10.1016/j.yebeh.2010.02.001 [doi]
PST - ppublish
SO  - Epilepsy Behav. 2010 Apr;17(4):569-70. doi: 10.1016/j.yebeh.2010.02.001. Epub
      2010 Mar 16.


PMID- 20236307
OWN - NLM
STAT- MEDLINE
DCOM- 20100928
LR  - 20151113
IS  - 1468-1331 (Electronic)
IS  - 1351-5101 (Linking)
VI  - 17
IP  - 6
DP  - 2010 Jun 1
TI  - Ethical issues in end of life treatments for patients with dementia.
PG  - 774-9
LID - 10.1111/j.1468-1331.2010.02991.x [doi]
AB  - Dementia is a terminal disease, associated with great suffering and difficult
      decisions in the severe stage. The decision-making process is characterized by
      uncertainty because of lack of scientific evidence in treatments and by the need 
      to reconcile conflicting points of view. In intercurrent diseases, aggressive
      interventions are used without consideration of its futility; in comparison with 
      cancer, several consequences of physicians' attitude not to consider dementia as 
      a terminal disease have been reported, especially concerning pain relief. Lack of
      evidence of artificial nutrition and hydration effectiveness makes advance care
      planning relevant.
FAU - Congedo, M
AU  - Congedo M
AD  - ASS n. 4 Medio Friuli, Ambulatorio di Neurologia, Distretto di Udine, Italy.
      mariolinacongedo@libero.it
FAU - Causarano, R I
AU  - Causarano RI
FAU - Alberti, F
AU  - Alberti F
FAU - Bonito, V
AU  - Bonito V
FAU - Borghi, L
AU  - Borghi L
FAU - Colombi, L
AU  - Colombi L
FAU - Defanti, C A
AU  - Defanti CA
FAU - Marcello, N
AU  - Marcello N
FAU - Porteri, C
AU  - Porteri C
FAU - Pucci, E
AU  - Pucci E
FAU - Tarquini, D
AU  - Tarquini D
FAU - Tettamanti, M
AU  - Tettamanti M
FAU - Tiezzi, A
AU  - Tiezzi A
FAU - Tiraboschi, P
AU  - Tiraboschi P
FAU - Gasparini, M
AU  - Gasparini M
CN  - Bioethics and Palliative Care in Neurology Study Group of Italian Society of
      Neurology
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100317
PL  - England
TA  - Eur J Neurol
JT  - European journal of neurology
JID - 9506311
SB  - IM
MH  - Decision Making
MH  - Dementia/*therapy
MH  - Humans
MH  - Palliative Care/*ethics/methods
MH  - Practice Guidelines as Topic
MH  - Terminal Care/*ethics/methods
RF  - 62
EDAT- 2010/03/20 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/03/19 06:00
PHST- 2010/03/19 06:00 [entrez]
PHST- 2010/03/20 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - ENE2991 [pii]
AID - 10.1111/j.1468-1331.2010.02991.x [doi]
PST - ppublish
SO  - Eur J Neurol. 2010 Jun 1;17(6):774-9. doi: 10.1111/j.1468-1331.2010.02991.x. Epub
      2010 Mar 17.


PMID- 20236131
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20220330
IS  - 1399-0012 (Electronic)
IS  - 0902-0063 (Linking)
VI  - 24
IP  - 5
DP  - 2010 Sep-Oct
TI  - Evaluation of living related kidney donors in China: policies and practices in a 
      transplant center.
PG  - E158-62
LID - 10.1111/j.1399-0012.2010.01229.x [doi]
AB  - BACKGROUND: Rigorous donor evaluation is essential for living related donor
      kidney transplantation (LRDKT). However, guidelines for living kidney donor
      evaluation are absent in China. The aim of this study is to describe the initial 
      experience in the living kidney donor evaluation process in a single transplant
      center in China. METHODS: The evaluation process of our center is sequentially
      divided into five steps: outpatient consultation and information, preliminary
      evaluation, comprehensive evaluation, final informed consent, and ethics
      committee oversight. RESULTS: Between June 2007 and March 2009, 124 potential
      living donors were evaluated in our center, of whom 82 (66.1%) became effective
      donors and the remaining 42 (33.9%) were excluded. The exclusion reasons were
      related to clinical problems in 27 cases, psychosocial problems in seven cases,
      and suspected organ trading in eight cases. CONCLUSION: Although strongly
      forbidden by Chinese laws, organ trading remains a threat to the healthy
      development of LRDKT in China. To prohibit organ trading, the kinship between the
      donor and recipient should be carefully identified. Guidelines for living donor
      evaluation appropriate to the actual situation in China should be set up for the 
      sake of safety and to protect the rights and interests of both donors and
      recipients.
CI  - (c) 2010 John Wiley & Sons A/S.
FAU - Zhao, Wen-Yu
AU  - Zhao WY
AD  - Organ Transplantation Institute of PLA, Changzheng Hospital, Second Military
      Medical University, Shanghai, China.
FAU - Zhang, Lei
AU  - Zhang L
FAU - Han, Shu
AU  - Han S
FAU - Zhu, You-Hua
AU  - Zhu YH
FAU - Wang, Li-Ming
AU  - Wang LM
FAU - Zhou, Mei-Sheng
AU  - Zhou MS
FAU - Zeng, Li
AU  - Zeng L
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - Denmark
TA  - Clin Transplant
JT  - Clinical transplantation
JID - 8710240
SB  - IM
MH  - Adult
MH  - China
MH  - Female
MH  - Humans
MH  - Kidney Transplantation/*ethics
MH  - Living Donors/*ethics
MH  - Male
MH  - Tissue and Organ Procurement/*ethics/*legislation & jurisprudence
EDAT- 2010/03/20 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/03/19 06:00
PHST- 2010/03/19 06:00 [entrez]
PHST- 2010/03/20 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - CTR1229 [pii]
AID - 10.1111/j.1399-0012.2010.01229.x [doi]
PST - ppublish
SO  - Clin Transplant. 2010 Sep-Oct;24(5):E158-62. doi:
      10.1111/j.1399-0012.2010.01229.x.


PMID- 20235866
OWN - NLM
STAT- MEDLINE
DCOM- 20100514
LR  - 20181113
IS  - 1556-2646 (Print)
IS  - 1556-2646 (Linking)
VI  - 5
IP  - 1
DP  - 2010 Mar
TI  - Attitudes toward genetic research review: results from a national survey of
      professionals involved in human subjects protection.
PG  - 83-91
LID - 10.1525/jer.2010.5.1.83 [doi]
AB  - The recent expansion of human genetics research has raised complex ethical and
      regulatory issues. However, few published reports describe the views of
      professionals involved in human subjects protection (HSP) regarding the risks and
      benefits of genetic research. This anonymous, web-based study elicited the
      opinions of 208 HSP professionals about review of genetic research. The majority 
      of respondents felt that different guidance is needed for various aspects of
      genetic protocol review compared with other types of human subjects research.
      Importantly, opinions were divided on specific genetic research issues, such as
      what constitutes human subjects research, when to re-consent, and the likelihood 
      and risks of research participant identification. Findings from this study
      illustrate the need for a collaborative approach to ethics oversight in the
      review and conduct of genetic research.
FAU - Lemke, Amy A
AU  - Lemke AA
AD  - Center for Genetic Medicine, Northwestern University, Chicago, IL 60611, USA.
      a-lemke@northwestern.edu
FAU - Trinidad, Susan B
AU  - Trinidad SB
FAU - Edwards, Karen L
AU  - Edwards KL
FAU - Starks, Helene
AU  - Starks H
FAU - Wiesner, Georgia L
AU  - Wiesner GL
CN  - GRRIP Consortium
LA  - eng
GR  - R01 CA149051/CA/NCI NIH HHS/United States
GR  - P50 HG003374-02/HG/NHGRI NIH HHS/United States
GR  - P50 HG003390/HG/NHGRI NIH HHS/United States
GR  - P50 HG003390-05/HG/NHGRI NIH HHS/United States
GR  - P50 HG003374-05/HG/NHGRI NIH HHS/United States
GR  - P50 HG003390-02/HG/NHGRI NIH HHS/United States
GR  - P50 HG003390-01/HG/NHGRI NIH HHS/United States
GR  - U01 HG004609-04/HG/NHGRI NIH HHS/United States
GR  - U01 HG004609-01/HG/NHGRI NIH HHS/United States
GR  - U01 HG004609/HG/NHGRI NIH HHS/United States
GR  - P50 HG003374-01/HG/NHGRI NIH HHS/United States
GR  - P50 HG003374-04/HG/NHGRI NIH HHS/United States
GR  - U01 HG004609-03/HG/NHGRI NIH HHS/United States
GR  - P50 HG003390-03/HG/NHGRI NIH HHS/United States
GR  - U01 HG004609-02/HG/NHGRI NIH HHS/United States
GR  - P50 HG003390-04/HG/NHGRI NIH HHS/United States
GR  - P50 HG003374-03/HG/NHGRI NIH HHS/United States
GR  - P50 HG003374/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - *Attitude
MH  - *Ethics Committees, Research
MH  - Female
MH  - Genetic Research/*ethics
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Male
MH  - United States
PMC - PMC2902178
MID - NIHMS213169
IR  - Boughman J
FIR - Boughman, Joann
IR  - Burke W
FIR - Burke, Wylie
IR  - Dressler L
FIR - Dressler, Lynn
IR  - Freeman W
FIR - Freeman, William
IR  - Gerson N
FIR - Gerson, Nancy
IR  - Juengst E
FIR - Juengst, Eric
IR  - Lewis S
FIR - Lewis, Susan
IR  - Marshall P
FIR - Marshall, Patricia
IR  - O'Rourke PP
FIR - O'Rourke, P Pearl
IR  - Ponsaran R
FIR - Ponsaran, Roselle
IR  - Press N
FIR - Press, Nancy
IR  - Griffin MQ
FIR - Griffin, Mary Quinn
EDAT- 2010/03/20 06:00
MHDA- 2010/05/15 06:00
CRDT- 2010/03/19 06:00
PHST- 2010/03/19 06:00 [entrez]
PHST- 2010/03/20 06:00 [pubmed]
PHST- 2010/05/15 06:00 [medline]
AID - 10.1525/jer.2010.5.1.83 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2010 Mar;5(1):83-91. doi: 10.1525/jer.2010.5.1.83.


PMID- 20235865
OWN - NLM
STAT- MEDLINE
DCOM- 20100514
LR  - 20181113
IS  - 1556-2646 (Print)
IS  - 1556-2646 (Linking)
VI  - 5
IP  - 1
DP  - 2010 Mar
TI  - Getting from A to IRB: developing an institutional review board at a historically
      black university.
PG  - 75-81
LID - 10.1525/jer.2010.5.1.75 [doi]
AB  - Shaw University, the oldest historically black college or university in the
      southern USA, recently partnered with the University of North Carolina at Chapel 
      Hill, a major research institution in North Carolina, to further develop Shaw's
      research infrastructure. One aim of the partnership involved establishing a human
      research ethics committee and an accompanying administrative structure and
      research ethics education program. This paper describes the process of developing
      an entire human research protection program de novo through collaboration with
      and mentoring by the members of the human research protection program at a nearby
      major research institution. This paper provides a detailed description of the
      aims, procedures, accomplishments, and challenges involved in such a project,
      which may serve as a useful model for other primarily teaching institutions
      wishing to develop research infrastructure and ethical capacity.
FAU - Howard, Daniel L
AU  - Howard DL
AD  - Shaw University. danielhoward@shawu
FAU - Boyd, Carlton L
AU  - Boyd CL
FAU - Nelson, Daniel K
AU  - Nelson DK
FAU - Godley, Paul
AU  - Godley P
LA  - eng
GR  - P60 MD000239/MD/NIMHD NIH HHS/United States
GR  - P60 MD000244/MD/NIMHD NIH HHS/United States
GR  - P60 MD000244-01/MD/NIMHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - *African Americans
MH  - Ethics Committees, Research/*organization & administration
MH  - Ethics, Research/*education
MH  - Humans
MH  - Interinstitutional Relations
MH  - North Carolina
MH  - Program Development
MH  - *Universities
PMC - PMC3148654
MID - NIHMS302463
EDAT- 2010/03/20 06:00
MHDA- 2010/05/15 06:00
CRDT- 2010/03/19 06:00
PHST- 2010/03/19 06:00 [entrez]
PHST- 2010/03/20 06:00 [pubmed]
PHST- 2010/05/15 06:00 [medline]
AID - 10.1525/jer.2010.5.1.75 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2010 Mar;5(1):75-81. doi: 10.1525/jer.2010.5.1.75.


PMID- 20235864
OWN - NLM
STAT- MEDLINE
DCOM- 20100514
LR  - 20100318
IS  - 1556-2646 (Print)
IS  - 1556-2646 (Linking)
VI  - 5
IP  - 1
DP  - 2010 Mar
TI  - Informed consent in human subject research: a comparison of current international
      and Nigerian guidelines.
PG  - 67-73
LID - 10.1525/jer.2010.5.1.67 [doi]
AB  - Informed consent is a basic requirement for the conduct of ethical research
      involving human subjects. Currently, the Helsinki Declaration of the World
      Medical Association and the International Ethical Guidelines for Biomedical
      Research of the Council for International Organizations of Medical Sciences
      (CIOMS) are widely accepted as international codes regulating human subject
      research and the informed consent sections of these documents are quite
      important. Debates on the applicability of these guidelines in different
      socio-cultural settings are ongoing and many workers have advocated the need for 
      national or regional guidelines. Nigeria, a developing country, has recently
      adopted its national guideline regulating human subject research: the National
      Health Research Ethics Committee (NHREC) code. A content analysis of the three
      guidelines was done to see if the Nigerian guidelines confer any additional
      protection for research subjects. The concept of a Community Advisory Committee
      in the Nigerian guideline is a novel one that emphasizes research as a community 
      burden and should promote a form of "research friendship" to foster the welfare
      of research participants. There is also the need for a regular update of the
      NHREC code so as to address some issues that were not considered in its current
      version.
FAU - Fadare, Joseph O
AU  - Fadare JO
AD  - Department of Medicine, Kogi State Specialist Hospital, Lokoja, Nigeria.
      jofadare@gmail.com
FAU - Porteri, Corinna
AU  - Porteri C
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - *Codes of Ethics
MH  - Cross-Cultural Comparison
MH  - *Ethics, Research
MH  - *Guidelines as Topic
MH  - Humans
MH  - Informed Consent/*ethics
MH  - *International Cooperation
MH  - Nigeria
EDAT- 2010/03/20 06:00
MHDA- 2010/05/15 06:00
CRDT- 2010/03/19 06:00
PHST- 2010/03/19 06:00 [entrez]
PHST- 2010/03/20 06:00 [pubmed]
PHST- 2010/05/15 06:00 [medline]
AID - 10.1525/jer.2010.5.1.67 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2010 Mar;5(1):67-73. doi: 10.1525/jer.2010.5.1.67.


PMID- 20235863
OWN - NLM
STAT- MEDLINE
DCOM- 20100514
LR  - 20100318
IS  - 1556-2646 (Print)
IS  - 1556-2646 (Linking)
VI  - 5
IP  - 1
DP  - 2010 Mar
TI  - Perspectives of Canadian researchers on ethics review of neuroimaging research.
PG  - 49-66
LID - 10.1525/jer.2010.5.1.49 [doi]
AB  - The current and potential uses of neuroimaging in healthcare and beyond have
      spurred discussion about the ethical issues related to neuroimaging and
      neuroimaging research. This study examined the perspectives of neuroimagers on
      ethical issues in their research and on the ethics review process. One hundred
      neuroimagers from 13 Canadian neuroscience centers completed an online survey and
      35 semi-structured interviews were conducted. Neuroimagers felt that most ethical
      and social issues identified in the literature were dealt with adequately, well, 
      and even very well by research ethics boards (REBs), but some issues such as
      incidental findings and transfer of knowledge were problematic. Neuroimagers
      reported a range of practical problems in the ethics review process. We aimed to 
      gather perspectives from REB on the ethics review process, but insufficient
      participation by REBs prevented us from reporting their perspectives. Given
      shortcomings identified by neuroimagers as well as longstanding issues in
      Canadian ethics governance, we believe that substantial challenges exist in
      Canadian research ethics governance that jeopardize trust, communication, and the
      overall soundness of research ethics governance. Neuroimagers and REBs should
      consider their shared responsibilities in developing guidance to handle issues
      such as incidental findings, risk assessment, and knowledge transfer.
FAU - Deslauriers, C
AU  - Deslauriers C
AD  - Neuroethics Research Unit, Institut de recherches cliniques de Montreal, Quebec, 
      Canada.
FAU - Bell, E
AU  - Bell E
FAU - Palmour, N
AU  - Palmour N
FAU - Pike, B
AU  - Pike B
FAU - Doyon, J
AU  - Doyon J
FAU - Racine, E
AU  - Racine E
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Canada
MH  - Diagnostic Imaging/*ethics
MH  - Diagnostic Techniques, Neurological/*ethics
MH  - Female
MH  - Humans
MH  - Incidental Findings
MH  - Information Dissemination
MH  - Magnetic Resonance Imaging/ethics
MH  - Male
MH  - *Peer Review, Research
EDAT- 2010/03/20 06:00
MHDA- 2010/05/15 06:00
CRDT- 2010/03/19 06:00
PHST- 2010/03/19 06:00 [entrez]
PHST- 2010/03/20 06:00 [pubmed]
PHST- 2010/05/15 06:00 [medline]
AID - 10.1525/jer.2010.5.1.49 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2010 Mar;5(1):49-66. doi: 10.1525/jer.2010.5.1.49.


PMID- 20235862
OWN - NLM
STAT- MEDLINE
DCOM- 20100514
LR  - 20181113
IS  - 1556-2646 (Print)
IS  - 1556-2646 (Linking)
VI  - 5
IP  - 1
DP  - 2010 Mar
TI  - Nine key functions for a human subjects protection program for community-engaged 
      research: points to consider.
PG  - 33-47
LID - 10.1525/jer.2010.5.1.33 [doi]
AB  - The ethical conduct of Community-Engaged Research (CEnR), of which the
      Community-Based Participatory Research (CBPR) model is the partnership model most
      widely discussed in the CEnR literature and is the primary model we draw upon in 
      this discussion, requires an integrated and comprehensive human subjects
      protection (HSP) program that addresses the additional concerns salient to CEnR
      where members of a community are both research partners and participants. As
      delineated in the federal regulations, the backbone of a HSP program is the
      fulfillment of nine functions: (1) minimize risks; (2) reasonable benefit-risk
      ratio; (3) fair subject selection; (4) adequate monitoring; (5) informed consent;
      (6) privacy and confidentiality; (7) conflicts of interest; (8) address
      vulnerabilities; and (9) HSP training. The federal regulations, however, do not
      consider the risks and harms that may occur to groups, and these risks have not
      traditionally been included in the benefit: risk analysis nor have they been
      incorporated into an HSP framework. We explore additional HSP issues raised by
      CEnR within these nine ethical functions. Various entities exist that can provide
      HSP---the investigator, the Institutional Review Board, the Conflict of Interest 
      Committee, the Research Ethics Consultation program, the Research Subject
      Advocacy program, the Data and Safety Monitoring Plan, and the Community Advisory
      Board. Protection is best achieved if these entities are coordinated to ensure
      that no gaps exist, to minimize unnecessary redundancy, and to provide checks and
      balances between the different entities of HSP and the nine functions that they
      must realize. The document is structured to provide a "points-to-consider"
      roadmap for HSP entities to help them adequately address the nine key functions
      necessary to provide adequate protection of individuals and communities in CEnR.
FAU - Ross, Lainie Friedman
AU  - Ross LF
AD  - Department of Pediatrics, University of Chicago, IL 60637, USA.
      lross@uchicago.edu
FAU - Loup, Allan
AU  - Loup A
FAU - Nelson, Robert M
AU  - Nelson RM
FAU - Botkin, Jeffrey R
AU  - Botkin JR
FAU - Kost, Rhonda
AU  - Kost R
FAU - Smith, George R
AU  - Smith GR
FAU - Gehlert, Sarah
AU  - Gehlert S
LA  - eng
GR  - UL1 TR000043/TR/NCATS NIH HHS/United States
GR  - UL1 RR024999/RR/NCRR NIH HHS/United States
GR  - UL1 RR024999-03/RR/NCRR NIH HHS/United States
GR  - UL1 TR000448/TR/NCATS NIH HHS/United States
GR  - UL1RR024999/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Community-Based Participatory Research/*ethics/*organization & administration
MH  - *Community-Institutional Relations
MH  - Confidentiality
MH  - Conflict of Interest
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Informed Consent
MH  - Patient Selection
MH  - Peer Review, Research
MH  - Research Personnel/education
MH  - *Risk Management
MH  - Social Justice
MH  - Vulnerable Populations
PMC - PMC2963647
MID - NIHMS235442
EDAT- 2010/03/20 06:00
MHDA- 2010/05/15 06:00
CRDT- 2010/03/19 06:00
PHST- 2010/03/19 06:00 [entrez]
PHST- 2010/03/20 06:00 [pubmed]
PHST- 2010/05/15 06:00 [medline]
AID - 10.1525/jer.2010.5.1.33 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2010 Mar;5(1):33-47. doi: 10.1525/jer.2010.5.1.33.


PMID- 20235860
OWN - NLM
STAT- MEDLINE
DCOM- 20100514
LR  - 20190108
IS  - 1556-2646 (Print)
IS  - 1556-2646 (Linking)
VI  - 5
IP  - 1
DP  - 2010 Mar
TI  - Human subjects protections in community-engaged research: a research ethics
      framework.
PG  - 5-17
LID - 10.1525/jer.2010.5.1.5 [doi]
AB  - In the 30 years since the Belmont Report, the role of the community in research
      has evolved and has taken on greater moral significance. Today, more and more
      translational research is being performed with the active engagement of
      individuals and communities rather than merely upon them. This engagement
      requires a critical examination of the range of risks that may arise when
      communities become partners in research. In attempting to provide such an
      examination, one must distinguish between established communities (groups that
      have their own organizational structure and leadership and exist regardless of
      the research) and unstructured groups (groups that may exist because of a shared 
      trait but do not have defined leadership or internal cohesiveness). In order to
      participate in research as a community, unstructured groups must develop
      structure either by external means (by partnering with a Community-Based
      Organization) or by internal means (by empowering the group to organize and
      establish structure and leadership). When groups participate in research, one
      must consider risks to well-being due to process and outcomes. These risks may
      occur to the individual qua individual, but there are also risks that occur to
      the individual qua member of a group and also risks that occur to the group qua
      group. There are also risks to agency, both to the individual and the group. A
      3-by-3 grid including 3 categories of risks (risks to well-being secondary to
      process, risks to well-being secondary to outcome and risks to agency) must be
      evaluated against the 3 distinct agents: individuals as individual participants, 
      individuals as members of a group (both as participants and as nonparticipants)
      and to communities as a whole. This new framework for exploring the risks in
      community-engaged research can help academic researchers and community partners
      ensure the mutual respect that community-engaged research requires.
FAU - Ross, Lainie Friedman
AU  - Ross LF
AD  - Department of Pediatrics, University of Chicago, IL 60637, USA.
      lross@uchicago.edu
FAU - Loup, Allan
AU  - Loup A
FAU - Nelson, Robert M
AU  - Nelson RM
FAU - Botkin, Jeffrey R
AU  - Botkin JR
FAU - Kost, Rhonda
AU  - Kost R
FAU - Smith, George R Jr
AU  - Smith GR Jr
FAU - Gehlert, Sarah
AU  - Gehlert S
LA  - eng
GR  - UL1 RR024999/RR/NCRR NIH HHS/United States
GR  - UL1 RR024999-03/RR/NCRR NIH HHS/United States
GR  - UL1 TR000448/TR/NCATS NIH HHS/United States
GR  - UL1RR024999/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Community-Based Participatory Research/*ethics
MH  - *Community-Institutional Relations
MH  - Human Experimentation/*ethics
MH  - Human Rights
MH  - Humans
MH  - Personal Autonomy
MH  - Risk Assessment
MH  - Terminology as Topic
PMC - PMC2946318
MID - NIHMS235438
EDAT- 2010/03/20 06:00
MHDA- 2010/05/15 06:00
CRDT- 2010/03/19 06:00
PHST- 2010/03/19 06:00 [entrez]
PHST- 2010/03/20 06:00 [pubmed]
PHST- 2010/05/15 06:00 [medline]
AID - 10.1525/jer.2010.5.1.5 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2010 Mar;5(1):5-17. doi: 10.1525/jer.2010.5.1.5.


PMID- 20235858
OWN - NLM
STAT- MEDLINE
DCOM- 20100514
LR  - 20211203
IS  - 1556-2646 (Print)
IS  - 1556-2646 (Linking)
VI  - 5
IP  - 1
DP  - 2010 Mar
TI  - New research domains create new ethical challenges.
PG  - 1-2
LID - 10.1525/jer.2010.5.1.1 [doi]
FAU - Sieber, Joan E
AU  - Sieber JE
LA  - eng
PT  - Editorial
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Community-Based Participatory Research/*ethics
MH  - *Guidelines as Topic
MH  - Humans
MH  - Translational Research, Biomedical/*ethics
EDAT- 2010/03/20 06:00
MHDA- 2010/05/15 06:00
CRDT- 2010/03/19 06:00
PHST- 2010/03/19 06:00 [entrez]
PHST- 2010/03/20 06:00 [pubmed]
PHST- 2010/05/15 06:00 [medline]
AID - 10.1525/jer.2010.5.1.1 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2010 Mar;5(1):1-2. doi: 10.1525/jer.2010.5.1.1.


PMID- 20235777
OWN - NLM
STAT- MEDLINE
DCOM- 20100623
LR  - 20121203
IS  - 1465-7309 (Electronic)
IS  - 1067-3229 (Linking)
VI  - 18
IP  - 2
DP  - 2010 Mar-Apr
TI  - Relational agents in clinical psychiatry.
PG  - 119-30
LID - 10.3109/10673221003707538 [doi]
AB  - Relational agents are computational artifacts, such as animated, screen-based
      characters or social robots, that are designed to establish a sense of rapport,
      trust, and even therapeutic alliance with patients, using ideal therapeutic
      relationships between human counselors and patients as role models. We describe
      the development and evaluation of several such agents designed for health
      counseling and behavioral-change interventions, in which a therapeutic alliance
      is established with patients in order to enhance the efficacy of the
      intervention. We also discuss the promise of using such agents as adjuncts to
      clinical psychiatry, a range of possible applications, and some of the challenges
      and ethical issues in developing and fielding them in psychiatric interventions.
FAU - Bickmore, Timothy
AU  - Bickmore T
AD  - Northeastern University, Boston, MA 02115, USA. bickmore@ccs.neu.edu
FAU - Gruber, Amanda
AU  - Gruber A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Harv Rev Psychiatry
JT  - Harvard review of psychiatry
JID - 9312789
SB  - IM
MH  - Counseling/methods
MH  - Humans
MH  - Internet/*instrumentation
MH  - Psychiatry/*instrumentation/*methods
EDAT- 2010/03/20 06:00
MHDA- 2010/06/24 06:00
CRDT- 2010/03/19 06:00
PHST- 2010/03/19 06:00 [entrez]
PHST- 2010/03/20 06:00 [pubmed]
PHST- 2010/06/24 06:00 [medline]
AID - 10.3109/10673221003707538 [doi]
PST - ppublish
SO  - Harv Rev Psychiatry. 2010 Mar-Apr;18(2):119-30. doi: 10.3109/10673221003707538.


PMID- 20235775
OWN - NLM
STAT- MEDLINE
DCOM- 20100623
LR  - 20121203
IS  - 1465-7309 (Electronic)
IS  - 1067-3229 (Linking)
VI  - 18
IP  - 2
DP  - 2010 Mar-Apr
TI  - Patient-targeted googling: the ethics of searching online for patient
      information.
PG  - 103-12
LID - 10.3109/10673221003683861 [doi]
AB  - With the growth of the Internet, psychiatrists can now search online for a wide
      range of information about patients. Psychiatrists face challenges of maintaining
      professional boundaries with patients in many circumstances, but little
      consideration has been given to the practice of searching online for information 
      about patients, an act we refer to as patient-targeted Googling (PTG).
      Psychiatrists are not the only health care providers who can investigate their
      patients online, but they may be especially likely to engage in PTG because of
      the unique relationships involved in their clinical practice. Before searching
      online for a patient, psychiatrists should consider such factors as the intention
      of searching, the anticipated effect of gaining information online, and its
      potential value or risk for the treatment. The psychiatrist is obligated to act
      in a way that respects the patient's best interests and that adheres to
      professional ethics. In this article, we propose a pragmatic model for
      considering PTG that focuses on practical results of searches and that aims to
      minimize the risk of exploiting patients. We describe three cases of PTG,
      highlighting important ethical dilemmas in multiple practice settings. Each case 
      is discussed from the standpoint of the pragmatic model.
FAU - Clinton, Brian K
AU  - Clinton BK
AD  - Harvard Medical School and McLean Hospital, Belmont, MA, USA. bkclinton@gmail.com
FAU - Silverman, Benjamin C
AU  - Silverman BC
FAU - Brendel, David H
AU  - Brendel DH
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Harv Rev Psychiatry
JT  - Harvard review of psychiatry
JID - 9312789
SB  - IM
EIN - Harv Rev Psychiatry. 2010 Jun;18(3):206
MH  - *Ethics
MH  - Humans
MH  - *Information Dissemination
MH  - Internet/*instrumentation
MH  - *Patients
MH  - *Physician-Patient Relations
MH  - Psychiatry/*instrumentation
MH  - Social Support
MH  - *Truth Disclosure
EDAT- 2010/03/20 06:00
MHDA- 2010/06/24 06:00
CRDT- 2010/03/19 06:00
PHST- 2010/03/19 06:00 [entrez]
PHST- 2010/03/20 06:00 [pubmed]
PHST- 2010/06/24 06:00 [medline]
AID - 10.3109/10673221003683861 [doi]
PST - ppublish
SO  - Harv Rev Psychiatry. 2010 Mar-Apr;18(2):103-12. doi: 10.3109/10673221003683861.


PMID- 20235424
OWN - NLM
STAT- MEDLINE
DCOM- 20100408
LR  - 20100318
IS  - 1544-6794 (Print)
IS  - 1544-6794 (Linking)
VI  - 8
IP  - 1
DP  - 2010 Jan-Feb
TI  - The complexity of reproductive decisions for patients with advanced cancer:
      ethical and communicative dimensions.
PG  - 45-8
FAU - Helft, Paul R
AU  - Helft PR
AD  - Division of Hematology/Oncology, Department of Medicine, Indiana University
      School of Medicine, Indiana University, Indianapolis 46202, USA. phelft@iupui.edu
FAU - Cavaghan, Melissa K
AU  - Cavaghan MK
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Support Oncol
JT  - The journal of supportive oncology
JID - 101181305
SB  - IM
MH  - Adult
MH  - *Communication
MH  - *Decision Making
MH  - Female
MH  - Humans
MH  - Male
MH  - Neoplasms/*psychology
MH  - Reproduction/*physiology
MH  - Reproductive Medicine/*ethics
EDAT- 2010/03/20 06:00
MHDA- 2010/04/09 06:00
CRDT- 2010/03/19 06:00
PHST- 2010/03/19 06:00 [entrez]
PHST- 2010/03/20 06:00 [pubmed]
PHST- 2010/04/09 06:00 [medline]
PST - ppublish
SO  - J Support Oncol. 2010 Jan-Feb;8(1):45-8.


PMID- 20235333
OWN - NLM
STAT- MEDLINE
DCOM- 20100617
LR  - 20220317
IS  - 1527-3350 (Electronic)
IS  - 0270-9139 (Linking)
VI  - 51
IP  - 6
DP  - 2010 Jun
TI  - Themes of liver transplantation.
PG  - 1869-84
LID - 10.1002/hep.23595 [doi]
AB  - Liver transplantation was the product of five interlocking themes. These began in
      1958-1959 with canine studies of then theoretical hepatotrophic molecules in
      portal venous blood (Theme I) and with the contemporaneous parallel development
      of liver and multivisceral transplant models (Theme II). Further Theme I
      investigations showed that insulin was the principal, although not the only,
      portal hepatotrophic factor. In addition to resolving long-standing controversies
      about the pathophysiology of portacaval shunt, the hepatotrophic studies blazed
      new trails in the regulation of liver size, function, and regeneration. They also
      targeted inborn metabolic errors (e.g., familial hyperlipoproteinemia) whose
      palliation by portal diversion presaged definitive correction with liver
      replacement. Clinical use of the Theme II transplant models depended on multiple 
      drug immunosuppression (Theme III, Immunology), guided by an empirical algorithm 
      of pattern recognition and therapeutic response. Successful liver replacement was
      first accomplished in 1967 with azathioprine, prednisone, and antilymphoid
      globulin. With this regimen, the world's longest surviving liver recipient is now
      40 years postoperative. Incremental improvements in survival outcome occurred
      (Theme IV) when azathioprine was replaced by cyclosporine (1979), which was
      replaced in turn by tacrolimus (1989). However, the biologic meaning of
      alloengraftment remained enigmatic until multilineage donor leukocyte
      microchimerism was discovered in 1992 in long-surviving organ recipients. Seminal
      mechanisms were then identified (clonal exhaustion-deletion and immune ignorance)
      that linked organ engraftment and the acquired tolerance of bone marrow
      transplantation and eventually clarified the relationship of transplantation
      immunology to the immunology of infections, neoplasms, and autoimmune disorders. 
      With this insight, better strategies of immunosuppression have evolved. As liver 
      and other kinds of organ transplantation became accepted as healthcare standards,
      the ethical, legal, equity, and the other humanism issues of Theme V have been
      resolved less conclusively than the medical-scientific problems of Themes I-IV.
FAU - Starzl, Thomas E
AU  - Starzl TE
AD  - Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh,
      PA, USA. mangant1@upmc.edu
FAU - Fung, John J
AU  - Fung JJ
LA  - eng
GR  - R01 DK029961-20/DK/NIDDK NIH HHS/United States
GR  - DK29961/DK/NIDDK NIH HHS/United States
PT  - Biography
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United States
TA  - Hepatology
JT  - Hepatology (Baltimore, Md.)
JID - 8302946
SB  - IM
MH  - Animals
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Liver Transplantation/*history
MH  - Physiology/history
RF  - 71
PS  - Starzl TE
FPS - Starzl, Thomas E
PMC - PMC4507423
MID - NIHMS221027
EDAT- 2010/03/18 06:00
MHDA- 2010/06/18 06:00
CRDT- 2010/03/18 06:00
PHST- 2010/03/18 06:00 [entrez]
PHST- 2010/03/18 06:00 [pubmed]
PHST- 2010/06/18 06:00 [medline]
AID - 10.1002/hep.23595 [doi]
PST - ppublish
SO  - Hepatology. 2010 Jun;51(6):1869-84. doi: 10.1002/hep.23595.


PMID- 20235289
OWN - NLM
STAT- MEDLINE
DCOM- 20100817
LR  - 20151119
IS  - 1553-5606 (Electronic)
IS  - 1553-5592 (Linking)
VI  - 5
IP  - 3
DP  - 2010 Mar
TI  - The ethics of the hospitalist model.
PG  - 183-8
LID - 10.1002/jhm.578 [doi]
AB  - The hospitalist model was founded on the premise that it could improve the
      quality and reduce the cost of hospital care. Many randomized studies have all
      but definitively proven this original assertion. Nevertheless, the hospitalist
      specialty raises lingering classical ethical issues: protecting the
      patient-physician relationship in an environment of increasing specialization and
      discontinuity of care, preserving patient autonomy and choice when structural
      changes are made in the provision of care, and ensuring that a model founded on
      efficiency and cost-effectiveness does not erode the public trust in hospitalists
      to always serve their patients' best interests. This work aims to serve as an
      update of these initial criticisms, showing how some questions have been
      answered, while some have not.
FAU - Rosenbloom, Adam Haley
AU  - Rosenbloom AH
AD  - Medical School for International Health, Ben-Gurion University of the Negev,
      Columbia University Medical Center, Be'er Sheva, Israel. rosenblo@bgu.ac.il
FAU - Jotkowitz, Alan
AU  - Jotkowitz A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Hosp Med
JT  - Journal of hospital medicine
JID - 101271025
SB  - IM
MH  - Advance Care Planning/ethics
MH  - Choice Behavior/*ethics
MH  - Continuity of Patient Care/ethics
MH  - Hospitalists/*ethics/organization & administration
MH  - Humans
MH  - Models, Organizational
MH  - Physician-Patient Relations
MH  - Practice Patterns, Physicians'
RF  - 57
EDAT- 2010/03/18 06:00
MHDA- 2010/08/18 06:00
CRDT- 2010/03/18 06:00
PHST- 2010/03/18 06:00 [entrez]
PHST- 2010/03/18 06:00 [pubmed]
PHST- 2010/08/18 06:00 [medline]
AID - 10.1002/jhm.578 [doi]
PST - ppublish
SO  - J Hosp Med. 2010 Mar;5(3):183-8. doi: 10.1002/jhm.578.


PMID- 20234993
OWN - NLM
STAT- MEDLINE
DCOM- 20100415
LR  - 20100317
IS  - 1439-4413 (Electronic)
IS  - 0012-0472 (Linking)
VI  - 135
IP  - 12
DP  - 2010 Mar
TI  - [Limiting life-prolonging treatments: a practical guidance reflecting the current
      legislation in Germany].
PG  - 570-4
LID - 10.1055/s-0030-1249217 [doi]
AB  - From the general ethical and legal requirements of medical interventions it can
      be inferred when life-prolonging treatments can or should be limited: If the
      intervention has no benefit for the patient and/or the properly informed patient 
      refuses to consent to the intervention. Two questions are especially challenging:
      When are medical interventions futile? And: How should decisions be made on
      behalf of incompetent patients? In accordance with prior high court rulings, the 
      new Civil Law legislation in Germany provides three standards for proxy decision 
      making: (1) the patients' written advance directive, (2) oral treatment
      preferences and substituted judgement, and (3) the patient's best interest.
      Thereby, (1) has priority over (2) and (2) has priority over (3). In addition,
      the article discusses conflicts between autonomy and well-being of the patient.
CI  - Copyright Georg Thieme Verlag KG Stuttgart . New York
FAU - Marckmann, G
AU  - Marckmann G
AD  - Institut fur Ethik und Geschichte der Medizin, Universitat Tubingen.
      georg.marckmann@uni-tuebingen.de
FAU - Sandberger, G
AU  - Sandberger G
FAU - Wiesing, U
AU  - Wiesing U
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Begrenzung lebenserhaltender Massnahmen: Eine Handreichung fur die Praxis auf der
      Grundlage der aktuellen Gesetzgebung.
DEP - 20100316
PL  - Germany
TA  - Dtsch Med Wochenschr
JT  - Deutsche medizinische Wochenschrift (1946)
JID - 0006723
SB  - IM
MH  - Delivery of Health Care/*legislation & jurisprudence/*standards
MH  - Germany
MH  - Humans
MH  - Patient Rights/*legislation & jurisprudence/*standards
MH  - *Practice Guidelines as Topic
MH  - Proxy/*legislation & jurisprudence
MH  - Treatment Refusal/*legislation & jurisprudence
EDAT- 2010/03/18 06:00
MHDA- 2010/04/16 06:00
CRDT- 2010/03/18 06:00
PHST- 2010/03/18 06:00 [entrez]
PHST- 2010/03/18 06:00 [pubmed]
PHST- 2010/04/16 06:00 [medline]
AID - 10.1055/s-0030-1249217 [doi]
PST - ppublish
SO  - Dtsch Med Wochenschr. 2010 Mar;135(12):570-4. doi: 10.1055/s-0030-1249217. Epub
      2010 Mar 16.


PMID- 20234389
OWN - NLM
STAT- MEDLINE
DCOM- 20101101
LR  - 20181113
IS  - 1476-5438 (Electronic)
IS  - 1018-4813 (Linking)
VI  - 18
IP  - 8
DP  - 2010 Aug
TI  - What is a meaningful result? Disclosing the results of genomic research in autism
      to research participants.
PG  - 867-71
LID - 10.1038/ejhg.2010.34 [doi]
AB  - Developments in genomics research have been accompanied by a controversial
      ethical injunction: that researchers disclose individually relevant research
      results to research participants. With the explosion of genomic research on
      complex psychiatric conditions such as autism, researchers must increasingly
      contend with whether--and which results--to report. We conducted a qualitative
      study with researchers and participants involved in autism genomics research,
      including 4 focus groups and 23 interviews with parents of autistic children, and
      23 interviews with researchers. Respondents considered genomic research results
      'reportable' when results were perceived to explain cause, and answer the
      question 'why;' that is, respondents set a standard for reporting individually
      relevant genetic research results to individual participants that is specific to 
      autism, reflecting the metaphysical value that genetic information is seen to
      offer in this context. In addition to this standard of meaning, respondents
      required that results be deemed 'true.' Here, respondents referenced standards of
      validity that were context nonspecific. Yet in practice, what qualified as 'true'
      depended on evidentiary standards within specific research disciplines as well as
      fundamental, and contested, theories about how autism is 'genetic.' For research 
      ethics, these finding suggest that uniform and context-free obligations regarding
      result disclosure cannot readily be specified. For researchers, they suggest that
      result disclosure to individuals should be justified not only by perceived
      meaning but also by clarity regarding appropriate evidentiary standards, and
      attention to the status of epistemological debates regarding the nature and cause
      of disorders.
FAU - Miller, Fiona Alice
AU  - Miller FA
AD  - Department of Health Policy, Management and Evaluation, University of Toronto,
      Toronto, Ontario, Canada. fiona.miller@utoronto.ca
FAU - Hayeems, Robin Zoe
AU  - Hayeems RZ
FAU - Bytautas, Jessica Peace
AU  - Bytautas JP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100317
PL  - England
TA  - Eur J Hum Genet
JT  - European journal of human genetics : EJHG
JID - 9302235
SB  - IM
MH  - Autistic Disorder/*genetics
MH  - Codes of Ethics
MH  - Disclosure/*ethics
MH  - Ethics, Research
MH  - Genetic Research/*ethics
MH  - Humans
MH  - Research Design
MH  - Research Personnel/*ethics
MH  - Research Subjects
MH  - Researcher-Subject Relations/*ethics
PMC - PMC2987386
EDAT- 2010/03/18 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/03/18 06:00
PHST- 2010/03/18 06:00 [entrez]
PHST- 2010/03/18 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - ejhg201034 [pii]
AID - 10.1038/ejhg.2010.34 [doi]
PST - ppublish
SO  - Eur J Hum Genet. 2010 Aug;18(8):867-71. doi: 10.1038/ejhg.2010.34. Epub 2010 Mar 
      17.


PMID- 20234010
OWN - NLM
STAT- MEDLINE
DCOM- 20100628
LR  - 20100317
IS  - 1941-2460 (Electronic)
IS  - 0003-0651 (Linking)
VI  - 58
IP  - 1
DP  - 2010 Feb
TI  - Ethics education in psychoanalytic training: a survey.
PG  - 83-99
LID - 10.1177/0003065110361250 [doi]
AB  - Didactic education in psychoanalytic ethics is a relatively new phenomenon.
      Ethics courses were offered by few institutes before they were mandated and
      before publication of the first Ethics Case Book in 2001. As institutes have
      developed ethics training, the solutions they have arrived at-formats, length and
      placement of courses, and preferred readings- remain unknown to other educators
      and analysts. This survey was undertaken to gain an overview of the current state
      of ethics education. Twenty-nine of the thirty-one training institutes of the
      American Psychoanalytic Association (93%) responded to inquiries. Most institutes
      (79%) offered one course, and the average number of class sessions was 6.3. Of
      258 different readings used, 61 (23.6%) were used by more than one institute and 
      37 (14.3%) by more than two. The most frequent topics were boundaries,
      confidentiality, and illness, and Dewald and Clark's Case Book (2008) and Gabbard
      and Lester (1995) were the most common readings. These findings should be useful 
      to instructors, curriculum committees, and ethics committees in their ethics
      education planning, as well as to practicing analysts in their ethical
      self-education. This study may also serve as a model for analogous investigations
      into other areas of analytic education and as an impetus to further research and 
      educational innovation.
FAU - Ransohoff, Paul M
AU  - Ransohoff PM
AD  - San Francisco Center for Psychoanalysis, USA. paul.ransohoff@gte.net
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Psychoanal Assoc
JT  - Journal of the American Psychoanalytic Association
JID - 7505579
SB  - IM
MH  - Curriculum
MH  - Data Collection
MH  - Ethics, Professional/*education
MH  - Humans
MH  - Professional-Patient Relations/*ethics
MH  - Psychoanalytic Therapy/*education/*ethics
MH  - *Teaching
EDAT- 2010/03/18 06:00
MHDA- 2010/06/29 06:00
CRDT- 2010/03/18 06:00
PHST- 2010/03/18 06:00 [entrez]
PHST- 2010/03/18 06:00 [pubmed]
PHST- 2010/06/29 06:00 [medline]
AID - 58/1/83 [pii]
AID - 10.1177/0003065110361250 [doi]
PST - ppublish
SO  - J Am Psychoanal Assoc. 2010 Feb;58(1):83-99. doi: 10.1177/0003065110361250.


PMID- 20233852
OWN - NLM
STAT- MEDLINE
DCOM- 20100709
LR  - 20151119
IS  - 1538-7755 (Electronic)
IS  - 1055-9965 (Linking)
VI  - 19
IP  - 4
DP  - 2010 Apr
TI  - International efforts to develop biospecimen best practices.
PG  - 912-5
LID - 10.1158/1055-9965.EPI-10-0058 [doi]
AB  - Variables introduced during the processes involved in biospecimen collection,
      processing, storage, and analysis are among the potential sources of bias in
      biomarker research. International efforts are under way to develop best practices
      to standardize biospecimen handling protocols. In general, documents on best
      practices address three major recurring themes: technical best practices on
      infrastructure and specimen handling, recommendations on informatics and data
      management, and recommendations on ethical, legal, and social issues. There are
      many areas of agreement among various international efforts, but no single set of
      practices has emerged as a unifying document. The ethical, legal, and social
      issues are particularly difficult to harmonize due to the many country-specific
      issues that are governed by a variety of local and federal rules and regulations.
      Given the increasingly international nature of research involving biomarkers and 
      biospecimens, it will be necessary to continue to cooperate in the development of
      harmonized evidence-based best practices. Several international organizations
      including the International Cancer Genome Consortium are engaged in such efforts.
FAU - Vaught, Jimmie B
AU  - Vaught JB
AD  - National Cancer Institute, Office of Biorepositories and Biospecimen Research, 31
      Center Drive, Room 10A03, Bethesda, MD 20892, USA. vaughtj@mail.nih.gov
FAU - Caboux, Elodie
AU  - Caboux E
FAU - Hainaut, Pierre
AU  - Hainaut P
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100316
PL  - United States
TA  - Cancer Epidemiol Biomarkers Prev
JT  - Cancer epidemiology, biomarkers & prevention : a publication of the American
      Association for Cancer Research, cosponsored by the American Society of
      Preventive Oncology
JID - 9200608
RN  - 0 (Biomarkers)
SB  - IM
MH  - Biomarkers/*analysis
MH  - Humans
MH  - Specimen Handling/methods/*standards
RF  - 14
EDAT- 2010/03/18 06:00
MHDA- 2010/07/10 06:00
CRDT- 2010/03/18 06:00
PHST- 2010/03/18 06:00 [entrez]
PHST- 2010/03/18 06:00 [pubmed]
PHST- 2010/07/10 06:00 [medline]
AID - 1055-9965.EPI-10-0058 [pii]
AID - 10.1158/1055-9965.EPI-10-0058 [doi]
PST - ppublish
SO  - Cancer Epidemiol Biomarkers Prev. 2010 Apr;19(4):912-5. doi:
      10.1158/1055-9965.EPI-10-0058. Epub 2010 Mar 16.


PMID- 20233356
OWN - NLM
STAT- MEDLINE
DCOM- 20101021
LR  - 20100625
IS  - 1471-6712 (Electronic)
IS  - 0283-9318 (Linking)
VI  - 24
IP  - 2
DP  - 2010 Jun
TI  - Dependency in autonomous caring--night nurses' working conditions for caring in
      nursing.
PG  - 312-20
LID - 10.1111/j.1471-6712.2009.00722.x [doi]
AB  - Few research studies have focused on nurses' working conditions for caring
      provided at night, and these studies have mainly described nurses' work in
      hospital settings, not in a municipal, social-care context. In Swedish municipal 
      care, nurses have responsibility for hundreds of older people in need of care.
      This working condition compromises caring encounters; instead the nurses' caring 
      is mainly mediated through care staff (or relatives). In considering that caring 
      based on caring encounters is fundamental to ethical nursing practice questions
      leads to the aim: to explore Swedish municipal night nurses' experiences of their
      working conditions for caring in nursing. All municipal night-duty nurses (n = 7)
      in a medium-sized community in Sweden participated in interviews, while six of
      them also wrote diaries. Thematic content analysis has been used in analysing the
      data. The findings revealed that the nurses experienced their working conditions 
      for caring in nursing in the themes of Dependency in the Organisation and Other
      Staff, Vocational Responsibility, Deficiency in Conditions for Caring and
      Autonomous Caring. The findings illustrate privileged, as well as, poor working
      conditions for caring in nursing. The nurses' role as consultants emerge as their
      main function. The consultant function implies that nurses do not participate in 
      ordinary bed-side caring, which makes it easier for them to find time for caring 
      in situations that arise when nurses' skills, expertise and authority are called 
      upon. Conversely the consultancy function entails short-term solution of complex 
      caring problems, which can signify deficient caring due to prevailing working
      conditions. The findings also point to nurses' possible problems in fulfilling
      their own and vocational demands for ethics in the practice of caring in nursing 
      related to existing working conditions.
FAU - Gustafsson, Christine
AU  - Gustafsson C
AD  - Department of Neurobiology, Care Sciences and Society, Division of Nursing,
      Karolinska Institutet, Stockholm, Sweden. christine.gustafsson@mdh.se
FAU - Fagerberg, Ingegerd
AU  - Fagerberg I
FAU - Asp, Margareta
AU  - Asp M
LA  - eng
PT  - Journal Article
DEP - 20100310
PL  - Sweden
TA  - Scand J Caring Sci
JT  - Scandinavian journal of caring sciences
JID - 8804206
MH  - *Nursing
MH  - *Nursing Staff, Hospital
MH  - Sweden
MH  - *Work Schedule Tolerance
EDAT- 2010/03/18 06:00
MHDA- 2010/10/22 06:00
CRDT- 2010/03/18 06:00
PHST- 2010/03/18 06:00 [entrez]
PHST- 2010/03/18 06:00 [pubmed]
PHST- 2010/10/22 06:00 [medline]
AID - SCS722 [pii]
AID - 10.1111/j.1471-6712.2009.00722.x [doi]
PST - ppublish
SO  - Scand J Caring Sci. 2010 Jun;24(2):312-20. doi: 10.1111/j.1471-6712.2009.00722.x.
      Epub 2010 Mar 10.


PMID- 20233312
OWN - NLM
STAT- MEDLINE
DCOM- 20100927
LR  - 20100517
IS  - 1601-0825 (Electronic)
IS  - 1354-523X (Linking)
VI  - 16
IP  - 4
DP  - 2010 May
TI  - What makes a high quality clinical research paper?
PG  - 313-5
LID - 10.1111/j.1601-0825.2010.01663.x [doi]
AB  - The quality of a research paper depends primarily on the quality of the research 
      study it reports. However, there is also much that authors can do to maximise the
      clarity and usefulness of their papers. Journals' instructions for authors often 
      focus on the format, style, and length of articles but do not always emphasise
      the need to clearly explain the work's science and ethics: so this review reminds
      researchers that transparency is important too. The research question should be
      stated clearly, along with an explanation of where it came from and why it is
      important. The study methods must be reported fully and, where appropriate, in
      line with an evidence based reporting guideline such as the CONSORT statement for
      randomised controlled trials. If the study was a trial the paper should state
      where and when the study was registered and state its registration identifier.
      Finally, any relevant conflicts of interest should be declared.
FAU - Groves, T
AU  - Groves T
AD  - BMJ, London, UK. tgroves@bmj.com
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100309
PL  - Denmark
TA  - Oral Dis
JT  - Oral diseases
JID - 9508565
MH  - *Clinical Trials as Topic
MH  - *Ethics, Research
MH  - Guidelines as Topic
MH  - Humans
MH  - Journalism, Medical/*standards
MH  - Periodicals as Topic
MH  - Publishing/*standards
MH  - Writing/*standards
RF  - 11
EDAT- 2010/03/18 06:00
MHDA- 2010/09/29 06:00
CRDT- 2010/03/18 06:00
PHST- 2010/03/18 06:00 [entrez]
PHST- 2010/03/18 06:00 [pubmed]
PHST- 2010/09/29 06:00 [medline]
AID - ODI1663 [pii]
AID - 10.1111/j.1601-0825.2010.01663.x [doi]
PST - ppublish
SO  - Oral Dis. 2010 May;16(4):313-5. doi: 10.1111/j.1601-0825.2010.01663.x. Epub 2010 
      Mar 9.


PMID- 20233193
OWN - NLM
STAT- MEDLINE
DCOM- 20100903
LR  - 20181113
IS  - 1365-2125 (Electronic)
IS  - 0306-5251 (Linking)
VI  - 69
IP  - 3
DP  - 2010 Mar
TI  - Informed consent document improvement does not increase patients' comprehension
      in biomedical research.
PG  - 231-7
LID - 10.1111/j.1365-2125.2009.03565.x [doi]
AB  - AIMS: International guidelines on ethics in biomedical research require that the 
      informed consent of all enrolled participants is obtained. A written document
      describing the research, the informed consent (IC) document, must be given to all
      participants by the investigator. Most IC documents are long, containing much
      information. The aim of the present study was to determine whether the
      modification of the IC document by a working group or systematic improvement in
      its lexicosyntactic readability can improve comprehension of the written
      information given to patients participating in biomedical research. METHODS: One 
      hundred and fifty-nine patients were randomized to read one of the three versions
      of the IC document: unchanged document, document modified using systematic
      improvement of lexicosyntactic readability and document modified by a working
      group. RESULTS: Neither the improvement in the lexicosyntactic readability, nor
      the intervention of the working group significantly improved the score of
      objective comprehension for the subjects included in this study: it was 66.6 (95%
      confidence interval 64.0, 69.2) for the control group, 68.8 (66.2, 71.4) for the 
      group with the document improved for lexicosyntactic readability and 69.2 (66.0, 
      72.4) for the group who read the document improved by the working group (P=
      0.38). CONCLUSIONS: We failed to show that improving IC document comprehension
      through a lexicosyntactic approach or by a working group leads to better
      comprehension.
FAU - Paris, Adeline
AU  - Paris A
AD  - Inserm, CHU Grenoble, France.
FAU - Brandt, Christian
AU  - Brandt C
FAU - Cornu, Catherine
AU  - Cornu C
FAU - Maison, Patrick
AU  - Maison P
FAU - Thalamas, Claire
AU  - Thalamas C
FAU - Cracowski, Jean-Luc
AU  - Cracowski JL
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Clin Pharmacol
JT  - British journal of clinical pharmacology
JID - 7503323
SB  - IM
CIN - Br J Clin Pharmacol. 2010 Mar;69(3):219-21. PMID: 20233191
MH  - Adult
MH  - Aged
MH  - *Biomedical Research
MH  - Communication
MH  - *Comprehension
MH  - Female
MH  - Humans
MH  - *Informed Consent
MH  - Male
MH  - Middle Aged
MH  - Patient Education as Topic
PMC - PMC2829692
EDAT- 2010/03/18 06:00
MHDA- 2010/09/04 06:00
CRDT- 2010/03/18 06:00
PHST- 2010/03/18 06:00 [entrez]
PHST- 2010/03/18 06:00 [pubmed]
PHST- 2010/09/04 06:00 [medline]
AID - BCP3565 [pii]
AID - 10.1111/j.1365-2125.2009.03565.x [doi]
PST - ppublish
SO  - Br J Clin Pharmacol. 2010 Mar;69(3):231-7. doi: 10.1111/j.1365-2125.2009.03565.x.


PMID- 20233191
OWN - NLM
STAT- MEDLINE
DCOM- 20100903
LR  - 20181113
IS  - 1365-2125 (Electronic)
IS  - 0306-5251 (Linking)
VI  - 69
IP  - 3
DP  - 2010 Mar
TI  - Drug code names and other ethics-related matters.
PG  - 219-21
LID - 10.1111/j.1365-2125.2010.03640.x [doi]
FAU - Ritter, J M
AU  - Ritter JM
LA  - eng
PT  - Comment
PT  - Editorial
PL  - England
TA  - Br J Clin Pharmacol
JT  - British journal of clinical pharmacology
JID - 7503323
RN  - 0 (Caffeic Acids)
RN  - 0 (Endothelin A Receptor Antagonists)
RN  - 0 (S 0139)
RN  - 6SMK8R7TGJ (Oleanolic Acid)
SB  - IM
CON - Br J Clin Pharmacol. 2010 Mar;69(3):231-7. PMID: 20233193
CON - Br J Clin Pharmacol. 2010 Mar;69(3):252-61. PMID: 20233196
MH  - Biomedical Research
MH  - Caffeic Acids/*administration & dosage
MH  - Drug Labeling/*ethics
MH  - Endothelin A Receptor Antagonists
MH  - Forearm/blood supply
MH  - Humans
MH  - Informed Consent
MH  - Oleanolic Acid/administration & dosage/*analogs & derivatives
MH  - Patient Education as Topic
PMC - PMC2829690
EDAT- 2010/03/18 06:00
MHDA- 2010/09/04 06:00
CRDT- 2010/03/18 06:00
PHST- 2010/03/18 06:00 [entrez]
PHST- 2010/03/18 06:00 [pubmed]
PHST- 2010/09/04 06:00 [medline]
AID - BCP3640 [pii]
AID - 10.1111/j.1365-2125.2010.03640.x [doi]
PST - ppublish
SO  - Br J Clin Pharmacol. 2010 Mar;69(3):219-21. doi:
      10.1111/j.1365-2125.2010.03640.x.


PMID- 20232817
OWN - NLM
STAT- MEDLINE
DCOM- 20100623
LR  - 20191210
IS  - 1520-6882 (Electronic)
IS  - 0003-2700 (Linking)
VI  - 82
IP  - 7
DP  - 2010 Apr 1
TI  - Single laboratory validation of a surface plasmon resonance biosensor screening
      method for paralytic shellfish poisoning toxins.
PG  - 2977-88
LID - 10.1021/ac1000338 [doi]
AB  - A research element of the European Union (EU) sixth Framework project BioCop
      focused on the development of a surface plasmon resonance (SPR) biosensor assay
      for the detection of paralytic shellfish poisoning (PSP) toxins in shellfish as
      an alternative to the increasingly ethically unacceptable mouse bioassay. A
      biosensor assay was developed using both a saxitoxin binding protein and chip
      surface in tandem with a highly efficient simple extraction procedure. The
      present report describes the single laboratory validation of this immunological
      screening method, for this complex group of toxins with differing toxicities,
      according to the European Decision 2002/657/EC in conjunction with IUPAC and AOAC
      single laboratory validation guidelines. The different performance
      characteristics (detection capability CCbeta, specificity/selectivity,
      repeatability, reproducibility, stability, and applicability) were determined in 
      relation to the EU regulatory limit of 800 microg of saxitoxin equivalents (STX
      eq) per kg of shellfish meat. The detection capability CCbeta was calculated to
      be 120 microg/kg. Intra-assay repeatability was found to be between 2.5 and 12.3%
      and interassay reproducibility was between 6.1 and 15.2% for different shellfish 
      matrices. Natural samples were also evaluated and the resultant data displayed
      overall agreements of 96 and 92% with that of the existing AOAC approved methods 
      of mouse bioassay (MBA) and high performance liquid chromatography (HPLC),
      respectively.
FAU - Campbell, Katrina
AU  - Campbell K
AD  - Institute of Agri-Food and Land Use (IAFLU), School of Biological Sciences,
      Queen's University Belfast, David Keir Building, Stranmillis Road, Belfast,
      Northern Ireland, BT9 5AG. katrina.campbell@qub.ac.uk
FAU - Haughey, Simon A
AU  - Haughey SA
FAU - van den Top, Hester
AU  - van den Top H
FAU - van Egmond, Hans
AU  - van Egmond H
FAU - Vilarino, Natalia
AU  - Vilarino N
FAU - Botana, Luis M
AU  - Botana LM
FAU - Elliott, Christopher T
AU  - Elliott CT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
PL  - United States
TA  - Anal Chem
JT  - Analytical chemistry
JID - 0370536
RN  - 0 (Antibodies)
RN  - 0 (Carrier Proteins)
RN  - 0 (Marine Toxins)
RN  - 35523-89-8 (Saxitoxin)
SB  - IM
MH  - Animals
MH  - Antibodies/chemistry/metabolism
MH  - Bivalvia/chemistry
MH  - Cardiidae/chemistry
MH  - Carrier Proteins/chemistry
MH  - Marine Toxins/analysis/*chemistry
MH  - Saxitoxin/analysis/chemistry/immunology
MH  - Shellfish Poisoning
MH  - Surface Plasmon Resonance/*methods
EDAT- 2010/03/18 06:00
MHDA- 2010/06/24 06:00
CRDT- 2010/03/18 06:00
PHST- 2010/03/18 06:00 [entrez]
PHST- 2010/03/18 06:00 [pubmed]
PHST- 2010/06/24 06:00 [medline]
AID - 10.1021/ac1000338 [doi]
PST - ppublish
SO  - Anal Chem. 2010 Apr 1;82(7):2977-88. doi: 10.1021/ac1000338.


PMID- 20232260
OWN - NLM
STAT- MEDLINE
DCOM- 20120210
LR  - 20220321
IS  - 1522-1709 (Electronic)
IS  - 1520-9512 (Linking)
VI  - 15
IP  - 3
DP  - 2011 Sep
TI  - Perioperative practical experiences in using a level 2 portable polysomnography.
PG  - 367-75
LID - 10.1007/s11325-010-0340-9 [doi]
AB  - PURPOSE: The objective of the study is to test the hypothesis that a level 2
      portable sleep device (Embletta X100) is a reliable alternative for standard PSG 
      in surgical patients. METHODS: After hospital ethics approvals, preoperative
      patients over 18 years old were recruited. The patients for validation underwent 
      standard PSG and Embletta X100 simultaneously in a sleep laboratory before
      surgery. The other patients received sleep studies with Embletta X100
      perioperatively. The correlation analysis and paired Student t test between
      variables from Embletta and from standard PSG were used to evaluate the accuracy 
      of Embletta. The quality of PSG recordings with Embletta was summarized. RESULT: 
      Twenty-one patients completed sleep study on both systems; ten females and ten
      males, age was 54 +/- 11 and BMI was 36 +/- 9. There was a significant
      correlation between the majority of parameters from standard PSG and Embeltta
      X100 with manual scoring. The inter-rater agreement was substantial to perfect at
      different AHI cutoffs with a Kappa coefficient of 0.69 to 1. A significant
      correlation between standard PSG and Embletta X100 with automatic scoring was
      found only in AHI and a few other parameters. In 385 patients, 1,002
      perioperative PSG recordings were carried out with Embletta. Of them, 889(88.7%) 
      were technically good and 90(9%) technically acceptable. Only 23 (2.3%) PSG
      recordings failed. CONCLUSION: Embletta X100, installed by a well-trained sleep
      technician, is a good alternative when standard PSG was not available or
      impractical. Manual scoring by a certified PSG technologist is the key for
      reliable results.
FAU - Chung, Frances
AU  - Chung F
AD  - Department of Anesthesia, University of Toronto, Toronto Western Hospital,
      University Health Network, Toronto, ON, Canada. Frances.Chung@uhn.on.ca
FAU - Liao, Pu
AU  - Liao P
FAU - Sun, Yuming
AU  - Sun Y
FAU - Amirshahi, Babak
AU  - Amirshahi B
FAU - Fazel, Hoda
AU  - Fazel H
FAU - Shapiro, Colin M
AU  - Shapiro CM
FAU - Elsaid, Hisham
AU  - Elsaid H
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20100316
PL  - Germany
TA  - Sleep Breath
JT  - Sleep & breathing = Schlaf & Atmung
JID - 9804161
SB  - IM
MH  - Adult
MH  - Aged
MH  - Equipment Design
MH  - Female
MH  - *Home Care Services
MH  - Humans
MH  - Male
MH  - Mass Screening
MH  - Middle Aged
MH  - Monitoring, Ambulatory/*instrumentation
MH  - *Perioperative Period
MH  - *Point-of-Care Systems
MH  - Polysomnography/*instrumentation
MH  - Reproducibility of Results
MH  - Signal Processing, Computer-Assisted/*instrumentation
MH  - Sleep Apnea, Obstructive/*diagnosis
MH  - Surgical Procedures, Operative
EDAT- 2010/03/17 06:00
MHDA- 2012/02/11 06:00
CRDT- 2010/03/17 06:00
PHST- 2009/10/07 00:00 [received]
PHST- 2010/02/08 00:00 [accepted]
PHST- 2010/03/17 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2012/02/11 06:00 [medline]
AID - 10.1007/s11325-010-0340-9 [doi]
PST - ppublish
SO  - Sleep Breath. 2011 Sep;15(3):367-75. doi: 10.1007/s11325-010-0340-9. Epub 2010
      Mar 16.


PMID- 20232073
OWN - NLM
STAT- MEDLINE
DCOM- 20110329
LR  - 20181113
IS  - 1433-8491 (Electronic)
IS  - 0940-1334 (Linking)
VI  - 260
IP  - 8
DP  - 2010 Dec
TI  - Do people with mental illness deserve what they get? Links between meritocratic
      worldviews and implicit versus explicit stigma.
PG  - 617-25
LID - 10.1007/s00406-010-0111-4 [doi]
AB  - Meritocratic worldviews that stress personal responsibility, such as the
      Protestant ethic or general beliefs in a just world, are typically associated
      with stigmatizing attitudes and could explain the persistence of mental illness
      stigma. Beliefs in a just world for oneself ("I get what I deserve"), however,
      are often related to personal well-being and can be a coping resource for
      stigmatized individuals. Despite these findings in other stigmatized groups, the 
      link between worldviews and the stigma of psychiatric disorders is unknown. We
      measured just world beliefs for self and others as well as endorsement of the
      Protestant ethic in 85 people with schizophrenia, schizoaffective or affective
      disorders and 50 members of the general public. Stigmatizing attitudes toward
      people with mental illness (perceived responsibility, perceived dangerousness,
      general agreement with negative stereotypes) were assessed by self-report. Using 
      a response-latency task, the Brief Implicit Association Test, we also examined
      guilt-related implicit negative stereotypes about mental illness. We found a
      consistent positive link between endorsing the Protestant ethic and stigmatizing 
      self-reported attitudes in both groups. Implicit guilt-related stereotypes were
      positively associated with the Protestant ethic only among members of the public.
      Among people with mental illness, stronger just world beliefs for self were
      related to reduced self-stigma, but also to more implicit blame of persons with
      mental illness. The Protestant ethic may increase (self-)stigmatizing attitudes; 
      just world beliefs for oneself, on the other hand, may lead to unexpected
      implicit self-blame in stigmatized individuals. Public anti-stigma campaigns and 
      initiatives to reduce self-stigma among people with mental illness should take
      worldviews into account.
FAU - Rusch, Nicolas
AU  - Rusch N
AD  - Illinois Institute of Technology, Chicago, IL, USA.
      nicolas.ruesch@uniklinik-freiburg.de
FAU - Todd, Andrew R
AU  - Todd AR
FAU - Bodenhausen, Galen V
AU  - Bodenhausen GV
FAU - Corrigan, Patrick W
AU  - Corrigan PW
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20100316
PL  - Germany
TA  - Eur Arch Psychiatry Clin Neurosci
JT  - European archives of psychiatry and clinical neuroscience
JID - 9103030
SB  - IM
MH  - Adult
MH  - *Attitude
MH  - *Culture
MH  - Female
MH  - Humans
MH  - Male
MH  - Mental Disorders/pathology/*physiopathology
MH  - Middle Aged
MH  - *Prejudice
MH  - Statistics as Topic
MH  - *Stereotyping
EDAT- 2010/03/17 06:00
MHDA- 2011/03/30 06:00
CRDT- 2010/03/17 06:00
PHST- 2009/11/13 00:00 [received]
PHST- 2010/03/01 00:00 [accepted]
PHST- 2010/03/17 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2011/03/30 06:00 [medline]
AID - 10.1007/s00406-010-0111-4 [doi]
PST - ppublish
SO  - Eur Arch Psychiatry Clin Neurosci. 2010 Dec;260(8):617-25. doi:
      10.1007/s00406-010-0111-4. Epub 2010 Mar 16.


PMID- 20232039
OWN - NLM
STAT- MEDLINE
DCOM- 20101206
LR  - 20210310
IS  - 1432-1238 (Electronic)
IS  - 0342-4642 (Linking)
VI  - 36
IP  - 9
DP  - 2010 Sep
TI  - Imminent brain death: point of departure for potential heart-beating organ donor 
      recognition.
PG  - 1488-94
LID - 10.1007/s00134-010-1848-y [doi]
AB  - PURPOSE: There is, in European countries that conduct medical chart review of
      intensive care unit (ICU) deaths, no consensus on uniform criteria for defining a
      potential organ donor. Although the term is increasingly being used in recent
      literature, it is seldom defined in detail. We searched for criteria for
      determination of imminent brain death, which can be seen as a precursor for organ
      donation. METHODS: We organized meetings with representatives from the field of
      clinical neurology, neurotraumatology, intensive care medicine, transplantation
      medicine, clinical intensive care ethics, and organ procurement management.
      During these meetings, all possible criteria were discussed to identify a patient
      with a reasonable probability to become brain dead (imminent brain death). We
      focused on the practical usefulness of two validated coma scales (Glasgow Coma
      Scale and the FOUR Score), brain stem reflexes and respiration to define imminent
      brain death. Further we discussed criteria to determine irreversibility and
      futility in acute neurological conditions. RESULTS: A patient who fulfills the
      definition of imminent brain death is a mechanically ventilated deeply comatose
      patient, admitted to an ICU, with irreversible catastrophic brain damage of known
      origin. A condition of imminent brain death requires either a Glasgow Coma Score 
      of 3 and the progressive absence of at least three out of six brain stem reflexes
      or a FOUR score of E(0)M(0)B(0)R(0). CONCLUSION: The definition of imminent brain
      death can be used as a point of departure for potential heart-beating organ donor
      recognition on the intensive care unit or retrospective medical chart analysis.
FAU - de Groot, Yorick J
AU  - de Groot YJ
AD  - Department of Intensive Care, Erasmus MC University Medical Center Rotterdam,
      P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.
FAU - Jansen, Nichon E
AU  - Jansen NE
FAU - Bakker, Jan
AU  - Bakker J
FAU - Kuiper, Michael A
AU  - Kuiper MA
FAU - Aerdts, Stan
AU  - Aerdts S
FAU - Maas, Andrew I R
AU  - Maas AI
FAU - Wijdicks, Eelco F M
AU  - Wijdicks EF
FAU - van Leiden, Hendrik A
AU  - van Leiden HA
FAU - Hoitsma, Andries J
AU  - Hoitsma AJ
FAU - Kremer, Berry H P H
AU  - Kremer BH
FAU - Kompanje, Erwin J O
AU  - Kompanje EJ
LA  - eng
PT  - Journal Article
DEP - 20100316
PL  - United States
TA  - Intensive Care Med
JT  - Intensive care medicine
JID - 7704851
SB  - IM
MH  - Brain Death/*diagnosis
MH  - Critical Care/*organization & administration
MH  - Europe
MH  - Humans
MH  - Intensive Care Units/organization & administration
MH  - Practice Guidelines as Topic
MH  - Professional Competence
MH  - Quality Assurance, Health Care
MH  - Tissue Donors/classification
MH  - Tissue and Organ Harvesting/ethics/*methods
MH  - Tissue and Organ Procurement/ethics/*organization & administration
MH  - Withholding Treatment/ethics/*standards
PMC - PMC2921050
EDAT- 2010/03/17 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/03/17 06:00
PHST- 2009/08/24 00:00 [received]
PHST- 2010/01/15 00:00 [accepted]
PHST- 2010/03/17 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1007/s00134-010-1848-y [doi]
PST - ppublish
SO  - Intensive Care Med. 2010 Sep;36(9):1488-94. doi: 10.1007/s00134-010-1848-y. Epub 
      2010 Mar 16.


PMID- 20231801
OWN - NLM
STAT- MEDLINE
DCOM- 20100618
LR  - 20110104
IS  - 1878-7401 (Electronic)
IS  - 0928-7329 (Linking)
VI  - 18
IP  - 1
DP  - 2010
TI  - Stage implementation of RFID in hospitals.
PG  - 31-46
LID - 10.3233/THC-2010-0570 [doi]
AB  - OBJECTIVES: The use of radio frequency identification device (RFID) technology
      within the healthcare industry was researched and specific instances of
      implementation of this technology in the hospital environment were examined.
      METHODS: The study primarily makes use of ideas from operations and supply chain 
      management, such as work flow diagrams, value stream mapping, and poka-yokes
      (mistake proofing measures) for investigations of processes, failures, and
      solutions. RESULTS: This study presents a step-by-step approach of how to
      implement the use of RFID tracking systems within the entire hospital. A number
      of poka-yokes were also devised for improving the safety of the patient and cost 
      effectiveness of the hospital to insure the success of the hospital health care
      delivery system. CONCLUSIONS: Many players in the hospital environment may be
      impacted. This includes patients, doctors, nurses, technicians, administrators,
      and other hospital personnel. Insurance and government agencies may be impacted
      as well. Different levels of training of hospital personnel will be required
      based on the degree of interaction with the RFID system. References to costs,
      Return On Investment, change management, ethical and legal considerations are
      also made to help the reader understand the benefits and implications of the
      technology in the hospital environment.
FAU - Kumar, Sameer
AU  - Kumar S
AD  - Opus College of Business, University of St. Thomas, Minneapolis, MN 55403-2005,
      USA. skumar@stthomas.edu
FAU - Livermont, Gregory
AU  - Livermont G
FAU - McKewan, Gregory
AU  - McKewan G
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Technol Health Care
JT  - Technology and health care : official journal of the European Society for
      Engineering and Medicine
JID - 9314590
SB  - IM
MH  - Cost Control
MH  - *Diffusion of Innovation
MH  - Efficiency, Organizational
MH  - Humans
MH  - Materials Management, Hospital/economics/*organization & administration
MH  - Patient Satisfaction
MH  - Program Development
MH  - Quality of Health Care
MH  - Radio Frequency Identification Device/*organization & administration
MH  - Research Design
MH  - Safety Management
MH  - United States
EDAT- 2010/03/17 06:00
MHDA- 2010/06/19 06:00
CRDT- 2010/03/17 06:00
PHST- 2010/03/17 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/06/19 06:00 [medline]
AID - BG71M730757G5787 [pii]
AID - 10.3233/THC-2010-0570 [doi]
PST - ppublish
SO  - Technol Health Care. 2010;18(1):31-46. doi: 10.3233/THC-2010-0570.


PMID- 20231658
OWN - NLM
STAT- MEDLINE
DCOM- 20100406
LR  - 20100316
IS  - 1538-361X (Electronic)
IS  - 0886-4470 (Linking)
VI  - 136
IP  - 3
DP  - 2010 Mar
TI  - Statistics or ethics? Decision to treat drooling.
PG  - 315; author reply 315-6
LID - 10.1001/archoto.2010.3 [doi]
FAU - Pitak-Arnnop, Poramate
AU  - Pitak-Arnnop P
LA  - eng
PT  - Comment
PT  - Letter
PL  - United States
TA  - Arch Otolaryngol Head Neck Surg
JT  - Archives of otolaryngology--head & neck surgery
JID - 8603209
SB  - IM
CON - Arch Otolaryngol Head Neck Surg. 2009 Sep;135(9):924-31. PMID: 19770427
MH  - Child
MH  - Helsinki Declaration
MH  - Humans
MH  - Informed Consent
MH  - Otorhinolaryngologic Surgical Procedures/*ethics
MH  - Sialorrhea/*surgery
MH  - Submandibular Gland/surgery
EDAT- 2010/03/17 06:00
MHDA- 2010/04/07 06:00
CRDT- 2010/03/17 06:00
PHST- 2010/03/17 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/04/07 06:00 [medline]
AID - 136/3/315 [pii]
AID - 10.1001/archoto.2010.3 [doi]
PST - ppublish
SO  - Arch Otolaryngol Head Neck Surg. 2010 Mar;136(3):315; author reply 315-6. doi:
      10.1001/archoto.2010.3.


PMID- 20231566
OWN - NLM
STAT- MEDLINE
DCOM- 20100415
LR  - 20181113
IS  - 1539-3704 (Electronic)
IS  - 0003-4819 (Linking)
VI  - 152
IP  - 6
DP  - 2010 Mar 16
TI  - Regulated payments for living kidney donation: an empirical assessment of the
      ethical concerns.
PG  - 358-65
LID - 10.7326/0003-4819-152-6-201003160-00005 [doi]
AB  - BACKGROUND: Although regulated payments to encourage living kidney donation could
      reduce morbidity and mortality among patients waiting for a kidney transplant,
      doing so raises several ethical concerns. OBJECTIVE: To determine the extent to
      which the 3 main concerns with paying kidney donors might manifest if a regulated
      market were created. DESIGN: Cross-sectional study of participants' willingness
      to donate a kidney in 12 scenarios. SETTING: Regional rail and urban trolley
      lines in Philadelphia County, Philadelphia, Pennsylvania. PARTICIPANTS: Of 550
      potential participants, 409 completed the questionnaire (response rate, 74.4%);
      342 of these participants were medically eligible to donate. INTERVENTION: Across
      scenarios, researchers experimentally manipulated the amount of money that
      participants would receive, the participants' risk for subsequently developing
      kidney failure themselves, and who would receive the donated kidney.
      MEASUREMENTS: The researchers determined whether payment represents an undue
      inducement by evaluating participants' sensitivity to risk in relation to the
      payment offered or an unjust inducement by evaluating participants' sensitivity
      to payment as a function of their annual income. The researchers also evaluated
      whether introducing payment would hinder altruistic donations by comparing
      participants' willingness to donate altruistically before versus after the
      introduction of payments. RESULTS: Generalized estimating equation models
      revealed that participants' willingness to donate increased significantly as
      their risk for kidney failure decreased, as the payment offered increased, and
      when the kidney recipient was a family member rather than a patient on a public
      waiting list (P < 0.001 for each). No statistical interactions were identified
      between payment and risk (odds ratio, 1.00 [95% CI, 0.96 to 1.03]) or between
      payment and income (odds ratio, 1.01 [CI, 0.99 to 1.03]). The proximity of these 
      estimates to 1.0 and narrowness of the CIs suggest that payment is neither an
      undue nor an unjust inducement, respectively. Alerting participants to the
      possibility of payment did not alter their willingness to donate for altruistic
      reasons (P = 0.40). LIMITATION: Choices revealed in hypothetical scenarios may
      not reflect real-world behaviors. CONCLUSION: Theoretical concerns about paying
      persons for living kidney donation are not corroborated by empirical evidence. A 
      real-world test of regulated payments for kidney donation is needed to
      definitively show whether payment provides a viable and ethical method to
      increase the supply of kidneys available for transplantation. PRIMARY FUNDING
      SOURCE: None.
FAU - Halpern, Scott D
AU  - Halpern SD
AD  - University of Pennsylvania School of Medicine and Philadelphia Veterans Affairs
      Medical Center, Philadelphia, Pennsylvania 19104-6021, USA.
      scott.halpern@uphs.upenn.edu
FAU - Raz, Amelie
AU  - Raz A
FAU - Kohn, Rachel
AU  - Kohn R
FAU - Rey, Michael
AU  - Rey M
FAU - Asch, David A
AU  - Asch DA
FAU - Reese, Peter
AU  - Reese P
LA  - eng
GR  - K23 DK078688/DK/NIDDK NIH HHS/United States
GR  - K23 DK078688-01/DK/NIDDK NIH HHS/United States
GR  - K23-078688-01/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ann Intern Med
JT  - Annals of internal medicine
JID - 0372351
SB  - IM
CIN - Ann Intern Med. 2010 Mar 16;152(6):396-7. PMID: 20231572
SPIN- Ann Intern Med. 2010 Mar 16;152(6):I-46. PMID: 20231551
MH  - Adult
MH  - Cost-Benefit Analysis
MH  - Cross-Sectional Studies
MH  - Family
MH  - Female
MH  - Humans
MH  - Income
MH  - Kidney Transplantation/*economics/*ethics
MH  - Living Donors/*ethics/psychology/supply & distribution
MH  - Male
MH  - Motivation
MH  - Philadelphia
MH  - Pilot Projects
MH  - Risk Factors
MH  - Waiting Lists
MH  - Young Adult
PMC - PMC2865248
MID - NIHMS196187
EDAT- 2010/03/17 06:00
MHDA- 2010/04/16 06:00
CRDT- 2010/03/17 06:00
PHST- 2010/03/17 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/04/16 06:00 [medline]
AID - 152/6/358 [pii]
AID - 10.7326/0003-4819-152-6-201003160-00005 [doi]
PST - ppublish
SO  - Ann Intern Med. 2010 Mar 16;152(6):358-65. doi:
      10.7326/0003-4819-152-6-201003160-00005.


PMID- 20231551
OWN - NLM
STAT- MEDLINE
DCOM- 20100415
LR  - 20130625
IS  - 1539-3704 (Electronic)
IS  - 0003-4819 (Linking)
VI  - 152
IP  - 6
DP  - 2010 Mar 16
TI  - Summaries for patients. The ethics of offering payment to living people who
      donate a kidney.
PG  - I-46
LID - 10.7326/0003-4819-152-6-201003160-00002 [doi]
LA  - eng
PT  - Patient Education Handout
PL  - United States
TA  - Ann Intern Med
JT  - Annals of internal medicine
JID - 0372351
SB  - IM
ORI - Ann Intern Med. 2010 Mar 16;152(6):358-65. PMID: 20231566
MH  - Adult
MH  - Cost-Benefit Analysis
MH  - Cross-Sectional Studies
MH  - Family
MH  - Female
MH  - Humans
MH  - Income
MH  - Kidney Transplantation/*economics/*ethics
MH  - Living Donors/*ethics/psychology/supply & distribution
MH  - Male
MH  - Motivation
MH  - Philadelphia
MH  - Pilot Projects
MH  - Risk Factors
MH  - Waiting Lists
MH  - Young Adult
EDAT- 2010/03/17 06:00
MHDA- 2010/04/16 06:00
CRDT- 2010/03/17 06:00
PHST- 2010/03/17 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/04/16 06:00 [medline]
AID - 152/6/I-46 [pii]
AID - 10.7326/0003-4819-152-6-201003160-00002 [doi]
PST - ppublish
SO  - Ann Intern Med. 2010 Mar 16;152(6):I-46. doi:
      10.7326/0003-4819-152-6-201003160-00002.


PMID- 20231248
OWN - NLM
STAT- MEDLINE
DCOM- 20100325
LR  - 20181113
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 340
DP  - 2010 Mar 15
TI  - Commentary: Ethics in conduct of trials in developing countries.
PG  - c1373
LID - 10.1136/bmj.c1373 [doi]
LID - bmj.c1373 [pii]
FAU - Weijer, Charles
AU  - Weijer C
AD  - Departments of Philosophy and Medicine, Joseph L Rotman Institute of Science and 
      Values, University of Western Ontario, London, ON, Canada. cweijer@uwo.ca
LA  - eng
PT  - Comment
PT  - Journal Article
DEP - 20100315
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
RN  - 0 (Adjuvants, Immunologic)
RN  - 0 (BCG Vaccine)
SB  - IM
CON - BMJ. 2010;340:c671. PMID: 20231251
MH  - *Adjuvants, Immunologic
MH  - *BCG Vaccine
MH  - Clinical Trials as Topic/*ethics
MH  - *Developing Countries
MH  - Guinea-Bissau
MH  - Humans
MH  - Immunization, Secondary/mortality
MH  - Infant
MH  - *Infant Mortality
PMC - PMC2839083
EDAT- 2010/03/17 06:00
MHDA- 2010/03/26 06:00
CRDT- 2010/03/17 06:00
PHST- 2010/03/17 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/03/26 06:00 [medline]
AID - 10.1136/bmj.c1373 [doi]
PST - epublish
SO  - BMJ. 2010 Mar 15;340:c1373. doi: 10.1136/bmj.c1373.


PMID- 20230976
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20100415
LR  - 20120910
IS  - 1532-3390 (Electronic)
IS  - 1532-3382 (Linking)
VI  - 10
IP  - 1
DP  - 2010 Mar
TI  - Poor oral hygiene, wearing dentures at night, perceptions of mouth dryness and
      burning, and lower educational level may be related to oral malodor in denture
      wearers.
PG  - 67-9
LID - 10.1016/j.jebdp.2009.11.026 [doi]
AB  - SUBJECTS: The study sample was recruited from edentulous patients seeking new
      dentures at the Kirikkale University Denture Clinic, Turkey. Male (n = 56) and
      female (n = 49) participants were enrolled and ranged from 50 to 78 years of age 
      (mean age 60.7 6 7.7 years). All 105 completed baseline evaluations, new denture 
      therapy, and follow-up examination approximately 4 weeks after denture treatment 
      completion. The study was approved by the institution's Ethics Committee. Dates
      for patient recruitment and conduct of the study were not provided. KEY
      EXPOSURE/STUDY FACTOR: For the prognostic component of the study, the primary
      factors of interest were sociodemographic characteristics, medical conditions
      previously related to oral malodor, and self-reported oral hygiene habits. The
      primary exposure for the interventional component was oral hygiene instruction,
      including brushing the tongue, cleaning the denture, and not wearing the denture 
      at night. After treatment with new dentures, participants were instructed to
      follow these hygiene instructions daily and were evaluated 4 weeks later. MAIN
      OUTCOME MEASURE: The primary outcome measure was the degree of oral malodor with 
      the original conventional dentures and following new denture treatment and oral
      hygiene instruction with 4 weeks of self-administered hygiene care. Oral malodor 
      was expressed both quantitatively as the number of parts per billion (ppb) of
      volatile sulfide compounds (VSCs) and as a binary measure (present/absent) based 
      on a threshold for oral malodor of greater than 110 ppb. MAIN RESULTS:
      Significant relationships with oral malodor (level of VSCs) at baseline with the 
      original denture were found for education (those having only primary school
      education were more likely to have higher VSC level, odds ratio [OR] 8.6, P =
      .046), self-reported oral dryness (OR 2.5, P = .037), self-reported overnight
      denture wear (OR 0.342 [likely a typographical error in the table; based on the
      95% CI of 1.59 to 8.35, the OR is probably 3.42], P = .002), and level of
      bacterial plaque coverage on the tongue (coating apparent on less than one third 
      of the tongue, OR = 26.4, P = .002; coating apparent on one third to two thirds
      of the tongue, OR 206.7, P = .0001). The level of VSCs dropped significantly (P <
      .01) from baseline (mean ppb108.1 623.2) to 4 weeks post new denture treatment
      completion and self-administered oral hygiene (mean ppb 104.0 619.7).
      CONCLUSIONS: The authors' conclusions were that ratings of elevated bacterial
      plaque on the tongue, subject perceptions oforal dryness and burning mouth,
      wearing dentures over-night, and lower educational levels were related to
      presence of oral malodor, and that tongue hygiene care and removal of dentures at
      night reduce oral malodor levels.
FAU - Garrett, Neal R
AU  - Garrett NR
AD  - Advanced Prosthodontics, Biomaterials, and Hospital Dentistry, Weintraub Center
      for Reconstructive Biotechnology, UCLA School of Dentistry, Los Angeles, CA
      90095-1668, USA. ngarrett@ucla.edu
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - J Evid Based Dent Pract
JT  - The journal of evidence-based dental practice
JID - 101083101
CON - Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 Jun;105(6):e5-9. PMID:
      18417390
EDAT- 2010/03/17 06:00
MHDA- 2010/03/17 06:01
CRDT- 2010/03/17 06:00
PHST- 2010/03/17 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/03/17 06:01 [medline]
AID - S1532-3382(09)00217-6 [pii]
AID - 10.1016/j.jebdp.2009.11.026 [doi]
PST - ppublish
SO  - J Evid Based Dent Pract. 2010 Mar;10(1):67-9. doi: 10.1016/j.jebdp.2009.11.026.


PMID- 20230959
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20100415
LR  - 20120910
IS  - 1532-3390 (Electronic)
IS  - 1532-3382 (Linking)
VI  - 10
IP  - 1
DP  - 2010 Mar
TI  - The bond between resin composite restorations and dentin may degrade in the mouth
      over time.
PG  - 21-2
LID - 10.1016/j.jebdp.2009.11.011 [doi]
AB  - SUBJECTS: The subjects were outpatients who attended the Department of Pediatric 
      Dentistry of Hokkaido University for treatment of caries. The laboratory study of
      the dentin-restoration interface of the pulpal wall of Class II composite resin
      restorations in extracted deciduousmolars were collected from 2 different
      sources. The first source was restored teeth from a prospective cohort with up to
      3 years of observations (n = 22), and the second source was intact teeth from a
      cross-sectional convenience sample that were subsequently prepared using the same
      restorative materials and procedure as in vivo and restored extraorally (n = 13) 
      as control specimens. Ethical approval was obtained by the appropriate
      institutional review board. KEY EXPOSURE/STUDY FACTOR: The primary study factor
      was the length of time spent by the resin-dentin bond in the oral cavity: (1)
      control (24 hours in distilled water only); (2) 1 to 2 years; or (3) 2 to 3
      years. MAIN OUTCOME MEASURE: The primary outcome measure was the integrity of the
      resin-dentin bond, measured within 2 weeks of tooth extraction represented by
      microtensile bond strength and by micromorphometric measurements of the fracture 
      surfaces in a scanning electron microscope. MAIN RESULTS: There were significant 
      differences inmicrotensile bond strengths among all 3 groups-control group, 28.3 
      +/- 11.3 MPa; 1 to 2 years, 15.2 +/- 4.4 MPa; 2 to 3 years, 9.1 +/- 5.1 MPa (P < 
      .05)-to suggest that the structural integrity of resin-dentin bonds decreased
      over time. The investigators related the characteristics of the microstructure of
      the fractured specimens to the observed reductions in microtensile bond strength 
      and attributed this association to in vivo degradation of adhesive and composite 
      resin and of exposed collagen located in the demineralized dentin beneath the
      resin-impregnated hybrid layer. CONCLUSIONS: The authors concluded that
      degradation of resin-dentin bond structures occurs after aging in the oral
      cavity.
FAU - Tam, Laura
AU  - Tam L
AD  - Restorative Dentistry, University of Toronto, Toronto, Ontario, Canada M5G 1G6.
      laura.tam@dentistry.utoronto.ca
FAU - Jokstad, Asbjorn
AU  - Jokstad A
LA  - eng
PT  - Comment
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Evid Based Dent Pract
JT  - The journal of evidence-based dental practice
JID - 101083101
CON - J Dent Res. 2000 Jun;79(6):1385-91. PMID: 10890717
EDAT- 2010/03/17 06:00
MHDA- 2010/03/17 06:01
CRDT- 2010/03/17 06:00
PHST- 2010/03/17 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/03/17 06:01 [medline]
AID - S1532-3382(09)00202-4 [pii]
AID - 10.1016/j.jebdp.2009.11.011 [doi]
PST - ppublish
SO  - J Evid Based Dent Pract. 2010 Mar;10(1):21-2. doi: 10.1016/j.jebdp.2009.11.011.


PMID- 20230519
OWN - NLM
STAT- MEDLINE
DCOM- 20101021
LR  - 20100625
IS  - 1471-6712 (Electronic)
IS  - 0283-9318 (Linking)
VI  - 24
IP  - 2
DP  - 2010 Jun
TI  - 'Have you had the test?' A discourse analysis of media presentation of prenatal
      screening in Iceland.
PG  - 414-21
LID - 10.1111/j.1471-6712.2009.00727.x [doi]
AB  - Nuchal translucency (NT) screening has come to be widely used in antenatal care
      in many countries. In the capital area of Iceland, which is the focus of this
      study, 84% of pregnant women underwent screening in 2005. At the time no official
      policy had been formulated regarding the use of this screening, and very limited 
      public discussion had taken place on the ethical issues related to its use.
      Although screening has been widely welcomed as a scientific and technological
      improvement, it may also have unintended consequences, both for practitioners and
      prospective parents, and for particular groups such as the disabled, which have
      not been fully explored. The purpose of this study was to examine how NT
      screening was introduced as a new practice and came to be adopted in prenatal
      care in Iceland. Using a genealogical approach, we explored the way in which the 
      value and potential drawbacks of NT screening were presented to the public. The
      data used in the analysis comprised material published from the beginning of 2000
      until the end of 2005, such as television programmes, newspaper and magazine
      articles and booklets written for prospective parents. The findings reveal that
      the screening was mainly promoted by staff at the specialized clinic where the
      test was offered, and that soon after its initiation screening became widespread.
      In interviews, both practitioners and parents of children with Down's syndrome
      questioned the eugenic implications of screening and its impact on the lives of
      the disabled and their relatives. However, the societal response was fairly muted
      and a critical debate regarding the routine use of NT screening can hardly be
      said to have taken place. These findings alert us to the importance of promoting 
      critical discussion of new knowledge and technology in health care, particularly 
      when serious ethical issues are involved.
FAU - Gottfredsdottir, Helga
AU  - Gottfredsdottir H
AD  - Department of Midwifery, Faculty of Nursing, University of Iceland, Reykjavik,
      Iceland. helgagot@hi.is
FAU - Bjornsdottir, Kristin
AU  - Bjornsdottir K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100307
PL  - Sweden
TA  - Scand J Caring Sci
JT  - Scandinavian journal of caring sciences
JID - 8804206
MH  - Female
MH  - Humans
MH  - Iceland
MH  - Pregnancy
MH  - *Prenatal Diagnosis
EDAT- 2010/03/17 06:00
MHDA- 2010/10/22 06:00
CRDT- 2010/03/17 06:00
PHST- 2010/03/17 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/10/22 06:00 [medline]
AID - SCS727 [pii]
AID - 10.1111/j.1471-6712.2009.00727.x [doi]
PST - ppublish
SO  - Scand J Caring Sci. 2010 Jun;24(2):414-21. doi: 10.1111/j.1471-6712.2009.00727.x.
      Epub 2010 Mar 7.


PMID- 20230074
OWN - NLM
STAT- MEDLINE
DCOM- 20100614
LR  - 20100316
IS  - 1939-1854 (Electronic)
IS  - 0021-9010 (Linking)
VI  - 95
IP  - 2
DP  - 2010 Mar
TI  - Would you work if you won the lottery? Tracking changes in the American work
      ethic.
PG  - 349-57
LID - 10.1037/a0018359 [doi]
AB  - Although many social scientists and political commentators have speculated that
      the American work ethic is in decline, the last longitudinal study of this issue 
      was conducted by Vecchio (1980) on data collected over 30 years ago. Vecchio
      examined whether workers would wish to continue working even if it were not
      financially necessary (i.e., the so-called lottery question from the National
      Opinion Research Center survey) and concluded that there had been a significant
      decline in work ethic since the 1950s. In the current study, the authors used an 
      updated data set that included data from 1980 through 2006 and found evidence for
      a declining trend since Vecchio's study, although the decline seems to be
      leveling out. Demographic characteristics do not account for this apparent
      decline in shared sentiments about the importance of work for a productive life. 
      The authors caution against drawing definitive conclusions, given the limitations
      of the lottery item as a measure of work ethic.
CI  - 2010 APA, all rights reserved
FAU - Highhouse, Scott
AU  - Highhouse S
AD  - Department of Psychology, Bowling Green State University, Bowling Green, OH
      43403, USA. shighho@bgsu.edu
FAU - Zickar, Michael J
AU  - Zickar MJ
FAU - Yankelevich, Maya
AU  - Yankelevich M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Appl Psychol
JT  - The Journal of applied psychology
JID - 0222526
SB  - IM
MH  - Adult
MH  - Data Collection
MH  - Employment/*psychology
MH  - Female
MH  - Gambling/*psychology
MH  - Humans
MH  - *Income
MH  - Job Satisfaction
MH  - Leisure Activities
MH  - Male
MH  - *Motivation
MH  - *Personnel Loyalty
MH  - Quality of Life/psychology
MH  - *Social Values
MH  - *Volition
EDAT- 2010/03/17 06:00
MHDA- 2010/06/15 06:00
CRDT- 2010/03/17 06:00
PHST- 2010/03/17 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/06/15 06:00 [medline]
AID - 2010-04488-010 [pii]
AID - 10.1037/a0018359 [doi]
PST - ppublish
SO  - J Appl Psychol. 2010 Mar;95(2):349-57. doi: 10.1037/a0018359.


PMID- 20229959
OWN - NLM
STAT- MEDLINE
DCOM- 20100421
LR  - 20161215
IS  - 0022-0124 (Print)
IS  - 0022-0124 (Linking)
VI  - 41
IP  - 3
DP  - 2010 Mar
TI  - Using active simulation to enhance learning of nursing ethics.
PG  - 104-5
LID - 10.3928/00220124-20100224-09 [doi]
AB  - Ethical decision making in health care is a complex issue that requires nurses to
      critically think about situations. Active simulation through the use of role-play
      was used as a teaching strategy for education on ethics. Participants served in
      various roles in simulations that encouraged nurses to examine their thoughts and
      feelings and use ethical decision-making models.
CI  - Copyright 2010, SLACK Incorporated.
FAU - Gropelli, Theresa M
AU  - Gropelli TM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Contin Educ Nurs
JT  - Journal of continuing education in nursing
JID - 0262321
MH  - Decision Making/ethics
MH  - Ethics Committees, Clinical
MH  - Ethics, Nursing/*education
MH  - Humans
MH  - *Role Playing
MH  - Teaching/*methods
MH  - United States
EDAT- 2010/03/17 06:00
MHDA- 2010/04/22 06:00
CRDT- 2010/03/17 06:00
PHST- 2010/03/17 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/04/22 06:00 [medline]
AID - 10.3928/00220124-20100224-09 [doi]
PST - ppublish
SO  - J Contin Educ Nurs. 2010 Mar;41(3):104-5. doi: 10.3928/00220124-20100224-09.


PMID- 20229456
OWN - NLM
STAT- MEDLINE
DCOM- 20100927
LR  - 20100416
IS  - 1439-4421 (Electronic)
IS  - 0941-3790 (Linking)
VI  - 72
IP  - 4
DP  - 2010 Apr
TI  - [From absolute necessity of dying to preventive planning of dying? The change of 
      social and medicine debates on dying in the 1980s].
PG  - e16-21
LID - 10.1055/s-0030-1249077 [doi]
AB  - International euthanasia debates focussing on "autonomous dying" in the 1980s
      corresponded with a general change in the health-care system: availability of new
      technical means with an analogous medical-ethic understanding of human suffering 
      and dying. This change is part of a general development from "passive health
      consumption" to "active prevention" in our society.
CI  - Georg Thieme Verlag KG Stuttgart, New York.
FAU - Jordan, I
AU  - Jordan I
AD  - Abteilung Geschichte, Ethik und Philosophie der Medizin, Medizinische Hochschule 
      Hannover. Jordan.Isabella@mh-hannover.de
LA  - ger
PT  - English Abstract
PT  - Historical Article
PT  - Journal Article
TT  - Von der Naturnotwendigkeit des Ablebens zur praventiven Sterbe-Gestaltung? Zum
      Wandel sozialer und medizinischer Sterbe-Debatten in den 80er Jahren.
DEP - 20100312
PL  - Germany
TA  - Gesundheitswesen
JT  - Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes
      (Germany))
JID - 9204210
SB  - IM
MH  - *Attitude to Death
MH  - Ethics, Medical/*history
MH  - Germany
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Life Expectancy/*history
MH  - *Personal Autonomy
MH  - Preventive Health Services/*history
MH  - Suicide, Assisted/*history
EDAT- 2010/03/17 06:00
MHDA- 2010/09/29 06:00
CRDT- 2010/03/16 06:00
PHST- 2010/03/16 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/09/29 06:00 [medline]
AID - 10.1055/s-0030-1249077 [doi]
PST - ppublish
SO  - Gesundheitswesen. 2010 Apr;72(4):e16-21. doi: 10.1055/s-0030-1249077. Epub 2010
      Mar 12.


PMID- 20229424
OWN - NLM
STAT- MEDLINE
DCOM- 20100406
LR  - 20100315
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 3
DP  - 2010 Mar
TI  - No ethical or legal imperative to provide life support to a permanently unaware
      patient.
PG  - 58-9
LID - 10.1080/15265160903581858 [doi]
FAU - Cantor, Norman L
AU  - Cantor NL
AD  - Rutgers Law School, Newark, NJ, USA. ncantor@andromeda.rutgers.edu
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2010 Mar;10(3):50-3. PMID: 20229421
MH  - Choice Behavior/ethics
MH  - Decision Making/*ethics
MH  - Dissent and Disputes
MH  - Health Care Rationing/ethics
MH  - Humans
MH  - Life Support Care/*ethics
MH  - Manitoba
MH  - Medical Futility/*ethics
MH  - Organizational Policy
MH  - Patient Advocacy/standards/trends
MH  - *Persistent Vegetative State
MH  - *Personal Autonomy
MH  - Physician's Role
MH  - Practice Guidelines as Topic
MH  - Terminal Care/*ethics
MH  - Withholding Treatment/*ethics/legislation & jurisprudence
EDAT- 2010/03/17 06:00
MHDA- 2010/04/07 06:00
CRDT- 2010/03/16 06:00
PHST- 2010/03/16 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/04/07 06:00 [medline]
AID - 919856934 [pii]
AID - 10.1080/15265160903581858 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Mar;10(3):58-9. doi: 10.1080/15265160903581858.


PMID- 20229421
OWN - NLM
STAT- MEDLINE
DCOM- 20100406
LR  - 20140325
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 3
DP  - 2010 Mar
TI  - The case of Samuel Golubchuk and the right to live.
PG  - 50-3
LID - 10.1080/15265160903581700 [doi]
AB  - Samuel Golubchuk was unwittingly at the center of a medical controversy with
      important ethical ramifications. Mr. Golubchuk, an 84-year-old patient whose
      precise neurological level of function was open to debate, was being artificially
      ventilated and fed by a gastrostomy tube prior to his death. According to all
      reports he was neither brain dead nor in a vegetative state. The physicians
      directly responsible for his care had requested that they be allowed to remove
      the patient from life support against the wishes of the patient's family.
      Concurrently the Manitoba College of Physicians and Surgeons released a statement
      which states that the final decision to withdraw life support lies with the
      physician. In our opinion the statement is ethically problematic for a number of 
      reasons. 1. It is an affront to the guiding principles of Western medical ethics:
      patient autonomy and human freedom. 2. The position of Samuel Golubchuk's
      physicians and the new statement lack cultural sensitivity towards other
      traditions. 3. In modern society there exists an erosion of a basic attitude
      towards the value of life. 4. The ability of physicians to predict life
      expectancy in terminally ill patients has been shown repeatedly to be quite
      limited.
FAU - Jotkowitz, Alan
AU  - Jotkowitz A
AD  - Ben-Gurion University of the Negev, Beer-Sheva, Israel. ajotkowitz@hotmail.com
FAU - Glick, Shimon
AU  - Glick S
FAU - Zivotofsky, Ari Z
AU  - Zivotofsky AZ
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CIN - Am J Bioeth. 2010 Mar;10(3):W6-7. PMID: 20229404
CIN - Am J Bioeth. 2010 Mar;10(3):54-6. PMID: 20229422
CIN - Am J Bioeth. 2010 Mar;10(3):56-7. PMID: 20229423
CIN - Am J Bioeth. 2010 Mar;10(3):58-9. PMID: 20229424
CIN - Am J Bioeth. 2010 Mar;10(3):59-61. PMID: 20229425
CIN - Am J Bioeth. 2010 Mar;10(3):61-3. PMID: 20229426
CIN - Am J Bioeth. 2010 Mar;10(3):64-5. PMID: 20229427
CIN - Am J Bioeth. 2010 Mar;10(3):65-6. PMID: 20229428
CIN - Am J Bioeth. 2010 Mar;10(3):67-8. PMID: 20229429
CIN - Am J Bioeth. 2010 Mar;10(3):69-70. PMID: 20229430
CIN - Am J Bioeth. 2010 Mar;10(3):71-3. PMID: 20229431
CIN - Am J Bioeth. 2010 Mar;10(3):73-4. PMID: 20229432
MH  - Aged, 80 and over
MH  - Canada
MH  - Choice Behavior/ethics
MH  - Cultural Characteristics
MH  - Decision Making/*ethics
MH  - *Dissent and Disputes
MH  - Enteral Nutrition/ethics
MH  - Ethics, Clinical
MH  - Ethics, Medical
MH  - *Freedom
MH  - Health Care Rationing/ethics
MH  - Humans
MH  - *Jews
MH  - Life Expectancy
MH  - Life Support Care/*ethics
MH  - Male
MH  - Manitoba
MH  - Medical Futility/*ethics
MH  - Persistent Vegetative State
MH  - *Personal Autonomy
MH  - Physician's Role
MH  - Practice Guidelines as Topic
MH  - Societies, Medical
MH  - Terminal Care/*ethics/methods
MH  - Terminally Ill
MH  - *Value of Life
MH  - Withholding Treatment/*ethics
EDAT- 2010/03/17 06:00
MHDA- 2010/04/07 06:00
CRDT- 2010/03/16 06:00
PHST- 2010/03/16 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/04/07 06:00 [medline]
AID - 919856613 [pii]
AID - 10.1080/15265160903581700 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Mar;10(3):50-3. doi: 10.1080/15265160903581700.


PMID- 20229415
OWN - NLM
STAT- MEDLINE
DCOM- 20100406
LR  - 20161125
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 3
DP  - 2010 Mar
TI  - Public health interventions need to meet the same standards of medical ethics as 
      individual health interventions.
PG  - 36-8
LID - 10.1080/15265160903581742 [doi]
FAU - Keane, Michael
AU  - Keane M
AD  - Casey Hospital, Victoria, Australia. mikekeane00@hotmail.com
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
RN  - 0 (Dietary Fats)
RN  - 0 (Trans Fatty Acids)
SB  - IM
CON - Am J Bioeth. 2010 Mar;10(3):27-32. PMID: 20229412
MH  - Choice Behavior
MH  - *Dietary Fats/administration & dosage
MH  - Ethics, Medical
MH  - *Feeding Behavior
MH  - Food Labeling/legislation & jurisprudence
MH  - *Freedom
MH  - Health Care Costs
MH  - *Health Promotion/ethics/legislation & jurisprudence/trends
MH  - Humans
MH  - *Legislation, Food/ethics/trends
MH  - *Nutrition Policy/legislation & jurisprudence/trends
MH  - *Personal Autonomy
MH  - *Public Health/ethics/legislation & jurisprudence/methods/trends
MH  - Social Justice
MH  - *Trans Fatty Acids
MH  - United States
MH  - Wedge Argument
EDAT- 2010/03/17 06:00
MHDA- 2010/04/07 06:00
CRDT- 2010/03/16 06:00
PHST- 2010/03/16 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/04/07 06:00 [medline]
AID - 919856907 [pii]
AID - 10.1080/15265160903581742 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Mar;10(3):36-8. doi: 10.1080/15265160903581742.


PMID- 20229411
OWN - NLM
STAT- MEDLINE
DCOM- 20100406
LR  - 20100315
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 3
DP  - 2010 Mar
TI  - Community members employed on research projects face crucial, often
      under-recognized, ethical dilemmas.
PG  - 24-6
LID - 10.1080/15265161003708623 [doi]
FAU - Molyneux, Sassy
AU  - Molyneux S
AD  - KEMRI /Wellcome Trust Research Programme, Kilifi, Kenya.
      smolyneux@kilifi.kemri-wellcome.org
FAU - Kamuya, Dorcas
AU  - Kamuya D
FAU - Marsh, Vicki
AU  - Marsh V
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2010 Mar;10(3):3-11. PMID: 20229402
MH  - Community-Based Participatory Research/*ethics/methods/*organization &
      administration
MH  - Employment
MH  - Humans
MH  - Kenya
MH  - Patient Selection/*ethics
MH  - *Peer Group
MH  - Research Design/trends
MH  - Research Personnel/*ethics
MH  - Sampling Studies
EDAT- 2010/03/17 06:00
MHDA- 2010/04/07 06:00
CRDT- 2010/03/16 06:00
PHST- 2010/03/16 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/04/07 06:00 [medline]
AID - 919857080 [pii]
AID - 10.1080/15265161003708623 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Mar;10(3):24-6. doi: 10.1080/15265161003708623.


PMID- 20229410
OWN - NLM
STAT- MEDLINE
DCOM- 20100406
LR  - 20100315
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 3
DP  - 2010 Mar
TI  - Disentangling methodologies: the ethics of traditional sampling methodologies,
      community-based participatory research, and respondent-driven sampling.
PG  - 22-4
LID - 10.1080/15265160903585628 [doi]
FAU - Constantine, Melissa
AU  - Constantine M
AD  - University of Minnesota, Minneapolis, MN, USA. cons0026@umn.edu
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2010 Mar;10(3):3-11. PMID: 20229402
MH  - Community-Based Participatory Research/*ethics/methods/organization &
      administration
MH  - Humans
MH  - Patient Selection/*ethics
MH  - *Peer Group
MH  - Research Design/*trends
MH  - *Sampling Studies
EDAT- 2010/03/17 06:00
MHDA- 2010/04/07 06:00
CRDT- 2010/03/16 06:00
PHST- 2010/03/16 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/04/07 06:00 [medline]
AID - 919857641 [pii]
AID - 10.1080/15265160903585628 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Mar;10(3):22-4. doi: 10.1080/15265160903585628.


PMID- 20229409
OWN - NLM
STAT- MEDLINE
DCOM- 20100406
LR  - 20100315
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 3
DP  - 2010 Mar
TI  - The role of community-based organizations in the recruitment of human subjects:
      ethical considerations.
PG  - 20-1
LID - 10.1080/15265161003599667 [doi]
FAU - Anderson, Emily E
AU  - Anderson EE
AD  - University of Illinois, Chicago, IL, USA. eander6@uic.edu
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2010 Mar;10(3):3-11. PMID: 20229402
MH  - Community-Based Participatory Research/*ethics/methods/organization &
      administration
MH  - Confidentiality
MH  - Employment
MH  - Ethics, Research
MH  - Humans
MH  - Patient Selection/*ethics
MH  - *Peer Group
MH  - Research Design/trends
MH  - Sampling Studies
MH  - Social Support
EDAT- 2010/03/17 06:00
MHDA- 2010/04/07 06:00
CRDT- 2010/03/16 06:00
PHST- 2010/03/16 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/04/07 06:00 [medline]
AID - 919857409 [pii]
AID - 10.1080/15265161003599667 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Mar;10(3):20-1. doi: 10.1080/15265161003599667.


PMID- 20229407
OWN - NLM
STAT- MEDLINE
DCOM- 20100406
LR  - 20121115
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 3
DP  - 2010 Mar
TI  - Ethical implications of peer-driven recruitment: guidelines from public health
      research.
PG  - 16-7
LID - 10.1080/15265160903585610 [doi]
FAU - Fry, Craig L
AU  - Fry CL
AD  - University of Melbourne,Victoria, Australia. craig.fry@mcri.edu.au
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2010 Mar;10(3):3-11. PMID: 20229402
MH  - Coercion
MH  - Community-Based Participatory Research/*ethics/methods/organization &
      administration
MH  - Ethical Analysis
MH  - Ethics, Research
MH  - *Guidelines as Topic
MH  - Humans
MH  - Informed Consent/ethics
MH  - Patient Selection/*ethics
MH  - *Peer Group
MH  - *Public Health
MH  - Research/*organization & administration
MH  - Research Design/trends
MH  - Sampling Studies
EDAT- 2010/03/17 06:00
MHDA- 2010/04/07 06:00
CRDT- 2010/03/16 06:00
PHST- 2010/03/16 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/04/07 06:00 [medline]
AID - 919857423 [pii]
AID - 10.1080/15265160903585610 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Mar;10(3):16-7. doi: 10.1080/15265160903585610.


PMID- 20229402
OWN - NLM
STAT- MEDLINE
DCOM- 20100406
LR  - 20181113
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 3
DP  - 2010 Mar
TI  - Community members as recruiters of human subjects: ethical considerations.
PG  - 3-11
LID - 10.1080/15265160903585578 [doi]
AB  - Few studies have considered in detail the ethical issues surrounding research in 
      which investigators ask community members to engage in research subject
      recruitment within their own communities. Peer-driven recruitment (PDR) and its
      variants are useful for accessing and including certain populations in research, 
      but also have the potential to undermine the ethical and scientific integrity of 
      community-based research. This paper examines the ethical implications of
      utilizing community members as recruiters of human subjects in the context of
      PDR, as well as the authors' experience with a variant of PDR in a research
      project in South Africa. The importance of situating PDR in a comprehensive
      community engagement process that is responsive to the constraints of science and
      local needs and interests is emphasized. The paper will have relevance to
      bioethicists, health researchers, and research regulators concerned about the
      appropriate use of peer-driven recruitment strategies in health research.
FAU - Simon, Christian
AU  - Simon C
AD  - School of Medicine, University of Iowa, IA, USA. Christian-simon@uiowa.edu
FAU - Mosavel, Maghboeba
AU  - Mosavel M
LA  - eng
GR  - R03 CA113086/CA/NCI NIH HHS/United States
GR  - R03 CA113086-01A1/CA/NCI NIH HHS/United States
GR  - CA 113086/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CIN - Am J Bioeth. 2010 Mar;10(3):W1-3. PMID: 20229401
CIN - Am J Bioeth. 2010 Mar;10(3):12-3. PMID: 20229405
CIN - Am J Bioeth. 2010 Mar;10(3):14-5. PMID: 20229406
CIN - Am J Bioeth. 2010 Mar;10(3):16-7. PMID: 20229407
CIN - Am J Bioeth. 2010 Mar;10(3):18-9. PMID: 20229408
CIN - Am J Bioeth. 2010 Mar;10(3):20-1. PMID: 20229409
CIN - Am J Bioeth. 2010 Mar;10(3):22-4. PMID: 20229410
CIN - Am J Bioeth. 2010 Mar;10(3):24-6. PMID: 20229411
MH  - Coercion
MH  - Community-Based Participatory Research/*ethics/methods/organization &
      administration
MH  - Humans
MH  - Informed Consent/ethics
MH  - International Cooperation
MH  - Patient Selection/*ethics
MH  - *Peer Group
MH  - Research Design/*trends
MH  - *Research Subjects/economics/psychology
MH  - Sampling Studies
MH  - Selection Bias
MH  - Social Support
MH  - South Africa
MH  - Trust
PMC - PMC3139466
MID - NIHMS212939
EDAT- 2010/03/17 06:00
MHDA- 2010/04/07 06:00
CRDT- 2010/03/16 06:00
PHST- 2010/03/16 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/04/07 06:00 [medline]
AID - 919858227 [pii]
AID - 10.1080/15265160903585578 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Mar;10(3):3-11. doi: 10.1080/15265160903585578.


PMID- 20229401
OWN - NLM
STAT- MEDLINE
DCOM- 20100406
LR  - 20181113
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 3
DP  - 2010 Mar
TI  - Response to open peer commentaries on "Community members as recruiters of human
      subjects: ethical considerations".
PG  - W1-3
LID - 10.1080/15265161003708508 [doi]
FAU - Simon, Christian
AU  - Simon C
AD  - School of Medicine, University of Iowa, IA, USA. Christian-simon@uiowa.edu
FAU - Mosavel, Maghboeba
AU  - Mosavel M
LA  - eng
GR  - R03 CA113086/CA/NCI NIH HHS/United States
GR  - R03 CA113086-01A1/CA/NCI NIH HHS/United States
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2010 Mar;10(3):3-11. PMID: 20229402
MH  - *Coercion
MH  - Community-Based Participatory Research/*ethics/methods/*organization &
      administration
MH  - Ethics, Research
MH  - Humans
MH  - Informed Consent/*ethics
MH  - International Cooperation
MH  - Patient Selection/*ethics
MH  - *Peer Group
MH  - *Research Design/trends
MH  - Research Subjects/economics/psychology
MH  - Sampling Studies
MH  - Selection Bias
MH  - *Social Support
MH  - South Africa
MH  - Trust
PMC - PMC3159565
MID - NIHMS304031
EDAT- 2010/03/17 06:00
MHDA- 2010/04/07 06:00
CRDT- 2010/03/16 06:00
PHST- 2010/03/16 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/04/07 06:00 [medline]
AID - 919858365 [pii]
AID - 10.1080/15265161003708508 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Mar;10(3):W1-3. doi: 10.1080/15265161003708508.


PMID- 20229041
OWN - NLM
STAT- MEDLINE
DCOM- 20101206
LR  - 20220331
IS  - 1432-1238 (Electronic)
IS  - 0342-4642 (Linking)
VI  - 36
IP  - 9
DP  - 2010 Sep
TI  - Type 2 diabetes mellitus is associated with impaired cytokine response and
      adhesion molecule expression in human endotoxemia.
PG  - 1548-55
LID - 10.1007/s00134-010-1845-1 [doi]
AB  - PURPOSE: Type 2 diabetes is associated with an increased risk of acquiring
      infectious diseases and developing sepsis. This may partly be due to immune
      dysfunction. We investigated the in vivo innate immune response of type 2
      diabetic persons to an intravenous injection of E. coli lipopolysaccharide (LPS).
      METHODS: After ethics approval, informed consent and a thorough physical
      examination, 19 type 2 diabetic patients and 23 healthy controls were included.
      LPS was given as an intravenous bolus injection of 0.3 ng/kg. Physiological
      variables, white blood cell count, and plasma concentrations of tumour necrosis
      factor (TNF), interleukin-6 (IL-6), interleukin-1 receptor antagonist (IL-1ra),
      and the adhesion molecules E-selectin, vascular adhesion molecule (VCAM)-1, and
      intracellular adhesion molecule (ICAM)-1 were measured hourly for 8 h. RESULTS:
      LPS injection induced a systemic inflammatory response with increases in
      neutrophils, temperature, heart rate and plasma concentrations of cytokines and
      adhesion molecules in healthy and type 2 diabetic volunteers. Type 2 diabetes was
      associated with less pronounced LPS-induced increases in TNF, IL-1ra, VCAM-1 and 
      ICAM-1. There was a trend towards an attenuated upregulation of E-selectin in
      diabetics, even though the plasma concentration tended to be generally higher
      compared to healthy controls. CONCLUSIONS: Patients with type 2 diabetes exhibit 
      an attenuated increase in plasma levels of TNF and IL-1ra, as well as an
      attenuated upregulation of VCAM-1 and ICAM-1 to LPS in vivo. This finding may
      provide a mechanistic explanation for the adverse outcome seen during infectious 
      diseases in diabetic patients.
FAU - Andreasen, Anne Sofie
AU  - Andreasen AS
AD  - Centre of Inflammation and Metabolism, Department of Infectious Diseases,
      University Hospital Rigshospitalet, Rigshospitalet-M 7641, Blegdamsvej 9, 2100,
      Copenhagen, Denmark. sofie_andreasen@msn.com
FAU - Pedersen-Skovsgaard, Theis
AU  - Pedersen-Skovsgaard T
FAU - Berg, Ronan M G
AU  - Berg RM
FAU - Svendsen, Kira Dynnes
AU  - Svendsen KD
FAU - Feldt-Rasmussen, Bo
AU  - Feldt-Rasmussen B
FAU - Pedersen, Bente K
AU  - Pedersen BK
FAU - Moller, Kirsten
AU  - Moller K
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100313
PL  - United States
TA  - Intensive Care Med
JT  - Intensive care medicine
JID - 7704851
RN  - 0 (Biomarkers)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Cytokines)
RN  - 0 (Endotoxins)
RN  - 0 (Interleukin-1)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
RN  - 67924-63-4 (endotoxin, Escherichia coli)
SB  - IM
MH  - Adaptive Immunity/immunology
MH  - Adult
MH  - Biomarkers/blood
MH  - Cell Adhesion Molecules/*metabolism
MH  - Cytokines/*blood
MH  - Diabetes Mellitus, Type 2/*immunology
MH  - Endotoxemia/*metabolism
MH  - Endotoxins/*pharmacology
MH  - Humans
MH  - Interleukin-1/blood
MH  - Lipopolysaccharides/*pharmacology
MH  - Male
MH  - Middle Aged
MH  - Tumor Necrosis Factor-alpha/analysis
MH  - Vascular Cell Adhesion Molecule-1/blood
EDAT- 2010/03/17 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/03/16 06:00
PHST- 2009/07/17 00:00 [received]
PHST- 2009/12/01 00:00 [accepted]
PHST- 2010/03/16 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1007/s00134-010-1845-1 [doi]
PST - ppublish
SO  - Intensive Care Med. 2010 Sep;36(9):1548-55. doi: 10.1007/s00134-010-1845-1. Epub 
      2010 Mar 13.


PMID- 20228905
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20200930
IS  - 1568-4156 (Electronic)
VI  - 10 Suppl
DP  - 2010 Jan 29
TI  - Council for international organizations of medical sciences perspectives:
      protecting persons through international ethics guidelines.
PG  - e008
FAU - Vallotton, Michel B
AU  - Vallotton MB
AD  - Geneva, Switzerland.
LA  - eng
PT  - Journal Article
DEP - 20100129
PL  - England
TA  - Int J Integr Care
JT  - International journal of integrated care
JID - 101214424
PMC - PMC2834899
EDAT- 2010/03/17 06:00
MHDA- 2010/03/17 06:01
CRDT- 2010/03/16 06:00
PHST- 2010/03/16 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/03/17 06:01 [medline]
AID - 10.5334/ijic.478 [doi]
PST - epublish
SO  - Int J Integr Care. 2010 Jan 29;10 Suppl:e008. doi: 10.5334/ijic.478.


PMID- 20228855
OWN - NLM
STAT- MEDLINE
DCOM- 20130516
LR  - 20220408
IS  - 1553-0779 (Electronic)
IS  - 1553-0779 (Linking)
VI  - 27
IP  - 3
DP  - 2010 Mar 10
TI  - NIH consensus development conference draft statement on vaginal birth after
      cesarean: new insights.
PG  - 1-42
AB  - OBJECTIVE: To provide health care providers, patients, and the general public
      with a responsible assessment of currently available data on vaginal birth after 
      cesarean (VBAC). PARTICIPANTS: A non-DHHS, nonadvocate 15-member panel
      representing the fields of obstetrics and gynecology, urogynecology, maternal and
      fetal medicine, pediatrics, midwifery, clinical pharmacology, medical ethics,
      internal medicine, family medicine, perinatal and reproductive psychiatry,
      anesthesiology, nursing, biostatistics, epidemiology, health care regulation,
      risk management, and a public representative, and a public representative. In
      addition, 21 experts from pertinent fields presented data to the panel and
      conference audience. EVIDENCE: Presentations by experts and a systematic review
      of the literature prepared by the Oregon Evidence-based Practice Center, through 
      the Agency for Healthcare Research and Quality. Scientific evidence was given
      precedence over anecdotal experience. CONFERENCE PROCESS: The panel drafted its
      statement based on scientific evidence presented in open forum and on published
      scientific literature. The draft statement was presented on the final day of the 
      conference and circulated to the audience for comment. The panel released a
      revised statement later that day at http://consensus.nih.gov. This statement is
      an independent report of the panel and is not a policy statement of the NIH or
      the Federal Government. CONCLUSIONS: Given the available evidence, trial of labor
      is a reasonable option for many pregnant women with one prior low transverse
      uterine incision. The data reviewed in this report show that both trial of labor 
      and elective repeat cesarean delivery for a pregnant woman with one prior
      transverse uterine incision have important risks and benefits and that these
      risks and benefits differ for the woman and her fetus. This poses a profound
      ethical dilemma for the woman, as well as her caregivers, because benefit for the
      woman may come at the price of increased risk for the fetus and vice versa. This 
      conundrum is worsened by the general paucity of high-level evidence about both
      medical and nonmedical factors, which prevents the precise quantification of
      risks and benefits that might help to make an informed decision about trial of
      labor compared with elective repeat cesarean delivery. The panel was mindful of
      these clinical and ethical uncertainties in making the following conclusions and 
      recommendations. One of the panel's major goals is to support pregnant women with
      one prior transverse uterine incision to make informed decisions about trial of
      labor compared with elective repeat cesarean delivery. The panel recommends that 
      clinicians and other maternity care providers use the responses to the six
      questions, especially questions 3 and 4, to incorporate an evidence-based
      approach into the decisionmaking process. Information, including risk assessment,
      should be shared with the woman at a level and pace that she can understand. When
      trial of labor and elective repeat cesarean delivery are medically equivalent
      options, a shared decisionmaking process should be adopted and, whenever
      possible, the woman's preference should be honored. The panel is concerned about 
      the barriers that women face in gaining access to clinicians and facilities that 
      are able and willing to offer trial of labor. Given the low level of evidence for
      the requirement for "immediately available" surgical and anesthesia personnel in 
      current guidelines, the panel recommends that the American College of
      Obstetricians and Gynecologists and the American Society of Anesthesiologists
      reassess this requirement with specific reference to other obstetric
      complications of comparable risk, risk stratification, and in light of limited
      physician and nursing resources. Healthcare organizations, physicians, and other 
      clinicians should consider making public their trial of labor policies and VBAC
      rates, as well as their plans for responding to obstetric emergencies. The panel 
      recommends that hospitals, maternity care providers, healthcare and professional 
      liability insurers, consumers, and policymakers collaborate on the development of
      integrated services that could mitigate or even eliminate current barriers to
      trial of labor. The panel is concerned that medical-legal considerations add to, 
      and in many instances exacerbate, these barriers to trial of labor. Policymakers,
      providers, and other stakeholders must collaborate in developing and implementing
      appropriate strategies to mitigate the chilling effect the medical-legal
      environment has on access to care. High-quality research is needed in many areas.
      The panel has identified areas that need attention in response to question 6.
      Research in these areas should be given appropriate priority and should be
      adequately funded--especially studies that would help to characterize more
      precisely the short-term and long-term maternal, fetal, and neonatal outcomes of 
      trial of labor and elective repeat cesarean delivery.
FAU - Cunningham, F Gary
AU  - Cunningham FG
AD  - Department of Obstetrics and Gynecology, University of Texas Southwestern Medical
      Center at Dallas, Dallas, Texas, USA.
FAU - Bangdiwala, Shrikant I
AU  - Bangdiwala SI
FAU - Brown, Sarah S
AU  - Brown SS
FAU - Dean, Thomas Michael
AU  - Dean TM
FAU - Frederiksen, Marilynn
AU  - Frederiksen M
FAU - Rowland Hogue, Carol J
AU  - Rowland Hogue CJ
FAU - King, Tekoa
AU  - King T
FAU - Spencer Lukacz, Emily
AU  - Spencer Lukacz E
FAU - McCullough, Laurence B
AU  - McCullough LB
FAU - Nicholson, Wanda
AU  - Nicholson W
FAU - Petit, Nancy Frances
AU  - Petit NF
FAU - Probstfield, Jeffrey Lynn
AU  - Probstfield JL
FAU - Viguera, Adele C
AU  - Viguera AC
FAU - Wong, Cynthia A
AU  - Wong CA
FAU - Zimmet, Sheila Cohen
AU  - Zimmet SC
LA  - eng
PT  - Consensus Development Conference, NIH
PT  - Journal Article
PT  - Review
PT  - Systematic Review
PL  - United States
TA  - NIH Consens State Sci Statements
JT  - NIH consensus and state-of-the-science statements
JID - 101160100
SB  - IM
MH  - Decision Making
MH  - Evidence-Based Medicine
MH  - Female
MH  - Guidelines as Topic
MH  - Humans
MH  - Patient Participation
MH  - Pregnancy
MH  - Public Policy
MH  - Risk Assessment
MH  - Risk Factors
MH  - *Trial of Labor
MH  - United States
MH  - *Vaginal Birth after Cesarean/trends
EDAT- 2010/03/17 06:00
MHDA- 2013/05/17 06:00
CRDT- 2010/03/16 06:00
PHST- 2010/03/16 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2013/05/17 06:00 [medline]
AID - 2010-000122-STMT [pii]
PST - ppublish
SO  - NIH Consens State Sci Statements. 2010 Mar 10;27(3):1-42.


PMID- 20228451
OWN - NLM
STAT- MEDLINE
DCOM- 20100611
LR  - 20100315
IS  - 1997-3322 (Electronic)
IS  - 1018-8185 (Linking)
VI  - 20
IP  - 1
DP  - 2010
TI  - Punishing physicians who torture: a work in progress.
PG  - 23-31
AB  - BACKGROUND: There are only a few anecdotal accounts describing physicians being
      punished for complicity with torture or crimes against humanity. A fuller list of
      such cases would address the perception that physicians may torture with impunity
      and point to how to improve their accountability for such crimes. METHODS: We
      performed a multilingual web search of the records of international and national 
      courts, military tribunals, medical associations (licensing boards and medical
      societies), medical and non-medical literature databases, human rights groups and
      media stories for reports of physicians who had been punished for complicity with
      torture or crimes against humanity that were committed after World War II.
      RESULTS: We found 56 physicians in eight countries who had been punished for
      complicity with torture or crimes against humanity. Courts punish crimes. Medical
      societies punish ethics violations. Fifty-one physicians (85%) had been punished 
      by the medical associations of five countries. Eleven (18%) had been punished by 
      domestic courts. International courts had imprisoned two (3%) physicians. Several
      were punished by courts and professional associations. There are open cases
      against 22 physicians. CONCLUSIONS: Punishments against physicians for crimes
      against humanity are becoming institutionalized. Medical associations must lead
      in shouldering responsibility for self-regulation in this matter. Physicians have
      supervised torture ever since medieval "Torture Physicians" certified that
      prisoners were medically capable of withstanding the torture and of providing the
      desired testimony. Revelations of sadistic medical experiments on prisoners
      during World War II turned the world against physician torturers and led to the
      "Doctor's Trial" at Nuremberg, a trial that held physicians accountable for
      crimes against humanity. This paper describes the largest case series of
      physicians who have been punished for abetting torture or other crimes against
      humanity committed after World War II. We wanted to: 1) describe and categorize
      the hearing procedures, 2) identify the roles of punished physicians, 3)
      categorize acts for which physicians are punished, and 4) describe the political 
      cultures in which punishments arise. Our larger aim was to learn whether
      punishments against physicians for abetting torture or crimes against humanity
      occur under sufficiently diverse environments as to inform generalizable public
      policy to punish and perhaps to deter this kind of medical misconduct.
FAU - Miles, Steven H
AU  - Miles SH
AD  - Center for Bioethics, University of Minnesota, USA. miles001@umn.edu
FAU - Alencar, Telma
AU  - Alencar T
FAU - Crock, Brittney N
AU  - Crock BN
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Torture
JT  - Torture : quarterly journal on rehabilitation of torture victims and prevention
      of torture
JID - 9309086
SB  - IM
MH  - Capital Punishment/legislation & jurisprudence
MH  - Crime/legislation & jurisprudence
MH  - Human Rights Abuses/legislation & jurisprudence
MH  - Humans
MH  - Physicians/*legislation & jurisprudence
MH  - Social Control, Formal
MH  - Torture/*legislation & jurisprudence
EDAT- 2010/03/17 06:00
MHDA- 2010/06/12 06:00
CRDT- 2010/03/16 06:00
PHST- 2010/03/16 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/06/12 06:00 [medline]
AID - 2010-1.2009-38 [pii]
PST - ppublish
SO  - Torture. 2010;20(1):23-31.


PMID- 20228390
OWN - NLM
STAT- MEDLINE
DCOM- 20100729
LR  - 20151119
IS  - 1460-2350 (Electronic)
IS  - 0268-1161 (Linking)
VI  - 25
IP  - 5
DP  - 2010 May
TI  - Who should pay for assisted reproductive techniques? Answers from patients,
      professionals and the general public in Germany.
PG  - 1225-33
LID - 10.1093/humrep/deq056 [doi]
AB  - BACKGROUND: Financing ART is variously regulated in the different countries of
      Europe. In Germany, coverage of assisted reproduction by statutory health
      insurances was restricted to 50% in 2004. We conducted a national survey among
      patients, professionals (physicians and other academics in IVF centres,
      psychosocial counsellors, medical ethicists, social lawyers, health politicians) 
      and the general public in Germany regarding their opinions on financing ART.
      METHODS: Standard questionnaire techniques (paper and pencil interviewing,
      computer-aided web interviewing, computer-aided telephone interviewing) were
      used. RESULTS: The vast majority of all groups supported public coverage of ART. 
      Co-payments by patients were considered appropriate by about one-third of the
      patients, two-third of the physicians and three quarters of all other groups.
      According to the respondents, the amount of co-payment should cover 15-25% of the
      costs, considerably less than what patients actually have to pay (50%). Support
      for public coverage was strongly correlated with the views (i) of infertility as 
      a disease, (ii) that there is a need for assisted reproduction for infertile
      couples and (iii) that every human should have the opportunity to have children. 
      The respondents had varying opinions on whether to increase medical insurance
      premiums in order to cover ART. Reducing services in other areas of health care
      in favour of reproductive medicine was supported only by the group of
      reproductive physicians. Financial incentives for oocyte sharing were rejected by
      most groups as was a money-back guarantee for unsuccessful treatments.
      CONCLUSIONS: Experts and the general public in Germany accept moderate
      co-payments for ART. No clear pattern of opinion emerged regarding the question
      of how public co-funding should be financed.
FAU - Rauprich, O
AU  - Rauprich O
AD  - Institute for Medical Ethics and History of Medicine, Ruhr-University Bochum,
      Markstr. 258a, D-44799 Bochum, Germany. oliver.rauprich@rub.de
FAU - Berns, E
AU  - Berns E
FAU - Vollmann, J
AU  - Vollmann J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100313
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
SB  - IM
MH  - Data Collection
MH  - Female
MH  - Financing, Personal/economics
MH  - Germany
MH  - Health Personnel
MH  - Humans
MH  - Infertility/economics/therapy
MH  - Insurance Coverage/economics
MH  - Male
MH  - National Health Programs/economics
MH  - Patients
MH  - Pregnancy
MH  - Public Opinion
MH  - Reproductive Techniques, Assisted/*economics
MH  - Surveys and Questionnaires
EDAT- 2010/03/17 06:00
MHDA- 2010/07/30 06:00
CRDT- 2010/03/16 06:00
PHST- 2010/03/16 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/07/30 06:00 [medline]
AID - deq056 [pii]
AID - 10.1093/humrep/deq056 [doi]
PST - ppublish
SO  - Hum Reprod. 2010 May;25(5):1225-33. doi: 10.1093/humrep/deq056. Epub 2010 Mar 13.


PMID- 20227847
OWN - NLM
STAT- MEDLINE
DCOM- 20100729
LR  - 20200415
IS  - 1873-2607 (Electronic)
IS  - 0749-3797 (Linking)
VI  - 38
IP  - 5
DP  - 2010 May
TI  - Effects of a college course about food and society on students' eating behaviors.
PG  - 543-7
LID - 10.1016/j.amepre.2010.01.026 [doi]
AB  - BACKGROUND: Health education programs for promoting a healthful diet have shown
      limited success in clinical trials. PURPOSE: This paper aims to examine whether
      an innovative educational course focused on societal-level issues related to food
      and food production (Food and Society) would promote healthful eating among
      college students. METHODS: A quasi-experimental non-RCT was conducted to compare 
      changes in eating behaviors among students taking the Food and Society course
      (n=28) versus students taking health-related human biology courses about obesity,
      health psychology, and community health assessment (n=72). All participants were 
      undergraduates. A Food Frequency Questionnaire was administered at the beginning 
      and end of the four courses taught from January through March 2009. Students in
      the Food and Society course read selected portions of popular books and essays
      (e.g., Michael Pollan's Omnivore's Dilemma) and watched documentaries (e.g.,
      Aaron Woolf's King Corn) highlighting environmental, ethical, social justice,
      cultural, political, and agricultural issues related to food and food production,
      and discussed these major themes during class sessions. In addition, students
      were required to (1) write an Op-Ed article and (2) create a brief YouTube video 
      focused on themes discussed in the course. RESULTS: The students who took the
      Food and Society course reported significantly improving their healthful eating
      (F[2, 97]=5.72, p=0.02), with greatest improvements in increased vegetable (F[2, 
      97]=10.96, p=0.001) and decreased high-fat dairy (F[2, 97]=5.39, p=0.02) intakes 
      relative to the comparison group. CONCLUSIONS: The results suggest that it may be
      possible to change dietary behaviors in college students by focusing on social,
      ethical, cultural, and environmental issues related to food and food production.
CI  - 2010 American Journal of Preventive Medicine. Published by Elsevier Inc. All
      rights reserved.
FAU - Hekler, Eric B
AU  - Hekler EB
AD  - Stanford Prevention Research Center, Stanford University School of Medicine,
      Stanford, California 94305-5705, USA. ehekler@stanford.edu
FAU - Gardner, Christopher D
AU  - Gardner CD
FAU - Robinson, Thomas N
AU  - Robinson TN
LA  - eng
GR  - T32 HL007034/HL/NHLBI NIH HHS/United States
GR  - 5 T32 HL 007034/HL/NHLBI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100315
PL  - Netherlands
TA  - Am J Prev Med
JT  - American journal of preventive medicine
JID - 8704773
SB  - IM
MH  - *Culture
MH  - *Curriculum
MH  - Feeding Behavior/*psychology
MH  - Female
MH  - *Food
MH  - *Health Education
MH  - Health Promotion
MH  - Humans
MH  - Male
MH  - Program Evaluation
MH  - Students
MH  - Surveys and Questionnaires
MH  - United States
MH  - Universities
MH  - Young Adult
PMC - PMC7153746
MID - NIHMS1578740
EDAT- 2010/03/17 06:00
MHDA- 2010/07/30 06:00
CRDT- 2010/03/16 06:00
PHST- 2009/09/10 00:00 [received]
PHST- 2009/11/13 00:00 [revised]
PHST- 2010/01/11 00:00 [accepted]
PHST- 2010/03/16 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/07/30 06:00 [medline]
AID - S0749-3797(10)00114-5 [pii]
AID - 10.1016/j.amepre.2010.01.026 [doi]
PST - ppublish
SO  - Am J Prev Med. 2010 May;38(5):543-7. doi: 10.1016/j.amepre.2010.01.026. Epub 2010
      Mar 15.


PMID- 20227344
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20100323
IS  - 1473-0502 (Print)
IS  - 1473-0502 (Linking)
VI  - 42
IP  - 2
DP  - 2010 Apr
TI  - Applying Applied Ethics through ethics consulting.
PG  - 209-14
LID - 10.1016/j.transci.2010.01.020 [doi]
AB  - Applied Ethics is frequently described as a discipline of philosophy that
      concerns itself with the application of moral theories such as deontology and
      utilitarianism to real world dilemmas. However, these applications often remain
      restricted to the academic world. The focus of new versions ethics consulting has
      since the mid-1980s shifted from what the ethicist knows to what the ethicist
      does or enables. This shift remodelled the ethicist's role to that of a
      facilitator in an inherently social process of moral inquiry. Applying these
      developments in the Namibian context has already proved to be of great value to
      the local health care industry.
CI  - (c) 2010. Published by Elsevier Ltd.
FAU - Moore, W
AU  - Moore W
AD  - University of Namibia, P.O. Box 828, Windhoek, Namibia. wmoore@therapinfo.com.na
LA  - eng
PT  - Journal Article
PL  - England
TA  - Transfus Apher Sci
JT  - Transfusion and apheresis science : official journal of the World Apheresis
      Association : official journal of the European Society for Haemapheresis
JID - 101095653
MH  - *Ethical Theory
MH  - Ethicists
MH  - *Ethics Consultation
MH  - Health Care Sector/*ethics
MH  - Humans
MH  - Namibia
EDAT- 2010/03/17 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/03/16 06:00
PHST- 2010/03/16 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - S1473-0502(10)00021-2 [pii]
AID - 10.1016/j.transci.2010.01.020 [doi]
PST - ppublish
SO  - Transfus Apher Sci. 2010 Apr;42(2):209-14. doi: 10.1016/j.transci.2010.01.020.


PMID- 20227050
OWN - NLM
STAT- MEDLINE
DCOM- 20100817
LR  - 20151119
IS  - 1097-6868 (Electronic)
IS  - 0002-9378 (Linking)
VI  - 203
IP  - 2
DP  - 2010 Aug
TI  - The perils of the imperfect expectation of the perfect baby.
PG  - 101.e1-5
LID - 10.1016/j.ajog.2010.01.058 [doi]
AB  - Advances in modern medicine invite the assumption that medicine can control human
      biology. There is a perilous logic that leads from expectations of medicine's
      control over reproductive biology to the expectation of having a perfect baby.
      This article proposes that obstetricians should take a preventive ethics approach
      to the care of pregnant women with expectations for a perfect baby. We use
      Nathaniel Hawthorne's classic short story, "The Birthmark," to illustrate the
      perils of the logic of control and perfection through science and then identify
      possible contemporary sources of the expectation of the perfect baby. We propose 
      that the informed consent process should be used as a preventive ethics tool
      throughout the course of pregnancy to educate pregnant women about the inherent
      errors of human reproduction, the highly variable clinical outcomes of these
      errors, the limited capacity of medicine to detect these errors, and the even
      more limited capacity to correct them.
CI  - Copyright (c) 2010 Mosby, Inc. All rights reserved.
FAU - Chervenak, Frank A
AU  - Chervenak FA
AD  - Department of Obstetrics and Gynecology, Weill Medical College of Cornell
      University, New York, NY 1006510065, USA. fac2001@med.cornell.edu
FAU - McCullough, Laurence B
AU  - McCullough LB
FAU - Brent, Robert L
AU  - Brent RL
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
DEP - 20100312
PL  - United States
TA  - Am J Obstet Gynecol
JT  - American journal of obstetrics and gynecology
JID - 0370476
SB  - IM
MH  - Abortion, Spontaneous
MH  - Congenital Abnormalities/diagnosis/*epidemiology
MH  - Female
MH  - Health Status
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Informed Consent
MH  - Male
MH  - Obstetrics/*ethics/standards/trends
MH  - Physician-Patient Relations/*ethics
MH  - Practice Patterns, Physicians'/ethics
MH  - Pregnancy
MH  - Pregnancy Complications/diagnosis/epidemiology
MH  - Pregnancy Outcome
MH  - Preventive Medicine/*ethics/standards
MH  - Reproductive History
MH  - Risk Assessment
MH  - Truth Disclosure/*ethics
RF  - 18
EDAT- 2010/03/17 06:00
MHDA- 2010/08/18 06:00
CRDT- 2010/03/16 06:00
PHST- 2009/10/15 00:00 [received]
PHST- 2009/11/15 00:00 [revised]
PHST- 2010/01/20 00:00 [accepted]
PHST- 2010/03/16 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/08/18 06:00 [medline]
AID - S0002-9378(10)00088-8 [pii]
AID - 10.1016/j.ajog.2010.01.058 [doi]
PST - ppublish
SO  - Am J Obstet Gynecol. 2010 Aug;203(2):101.e1-5. doi: 10.1016/j.ajog.2010.01.058.
      Epub 2010 Mar 12.


PMID- 20226982
OWN - NLM
STAT- MEDLINE
DCOM- 20100330
LR  - 20150616
IS  - 1474-547X (Electronic)
IS  - 0140-6736 (Linking)
VI  - 375
IP  - 9718
DP  - 2010 Mar 13
TI  - Ethical standards in Cambodia: is silent witnessing sufficient?
PG  - 892
LID - 10.1016/S0140-6736(10)60384-4 [doi]
FAU - Loff, Bebe
AU  - Loff B
FAU - Overs, Cheryl
AU  - Overs C
LA  - eng
PT  - Comment
PT  - Letter
PL  - England
TA  - Lancet
JT  - Lancet (London, England)
JID - 2985213R
RN  - 0 (Plant Preparations)
SB  - IM
CON - Lancet. 2010 Jan 16;375(9710):187-8. PMID: 20109905
MH  - Cambodia
MH  - Government Programs/*ethics
MH  - Humans
MH  - Mandatory Programs/*ethics
MH  - Opioid-Related Disorders/*rehabilitation
MH  - Plant Preparations/*therapeutic use
EDAT- 2010/03/17 06:00
MHDA- 2010/03/31 06:00
CRDT- 2010/03/16 06:00
PHST- 2010/03/16 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/03/31 06:00 [medline]
AID - S0140-6736(10)60384-4 [pii]
AID - 10.1016/S0140-6736(10)60384-4 [doi]
PST - ppublish
SO  - Lancet. 2010 Mar 13;375(9718):892. doi: 10.1016/S0140-6736(10)60384-4.


PMID- 20226850
OWN - NLM
STAT- MEDLINE
DCOM- 20100617
LR  - 20131121
IS  - 1879-3177 (Electronic)
IS  - 0887-2333 (Linking)
VI  - 24
IP  - 4
DP  - 2010 Jun
TI  - BALB/c 3T3 cell transformation assay for the prediction of carcinogenic potential
      of chemicals and environmental mixtures.
PG  - 1292-300
LID - 10.1016/j.tiv.2010.03.003 [doi]
AB  - The prediction of the carcinogenic risk for humans is mostly based on animal
      experiments. For the last 20 years, however, the scientific community has paid
      great attention to alternative strategies in compliance with common moral and
      ethical values. The new European chemical regulation REACH (Reg. EC 1907/2006)
      requires the performance of new studies in vertebrates only as a last resort.
      REACH asks for the development of validated in vitro protocols that can replace, 
      in the medium to the long term, animal bioassays. An in vitro cell transformation
      assay (CTA) is proposed as an alternative to in vivo carcinogenicity testing.
      This assay is reported in the list of accepted methods for REACH (Reg. EC
      440/2008). The BALB/c 3T3 model represents one of the most well-known CTAs and is
      regarded as a useful tool to screen single chemicals or complex mixtures for
      carcinogenicity prediction. In this study we used a modified protocol to
      highlight the transforming potential of three single compounds, ethinylestradiol 
      (EE), azathioprine (AZA-T), melphalan, and two polychlorinated biphenyls (PCBs)
      mixtures, which are known or suspected to be human carcinogens. We also evaluated
      the activity of the antioxidant alpha-lipoic acid (ALA), a promising tumor
      chemopreventive. A significant increase in transformation frequency was observed 
      when the BALB/c 3T3 cells were exposed to EE, AZA-T or melphalan as well as after
      PCBs treatment. On the contrary, ALA did not induce any increase of foci
      occurrence. Our results confirm the suitability of the improved protocol to
      discriminate carcinogenic compounds and support the use of BALB/c 3T3 cell
      transformation assay as a possible alternative to predict carcinogenic risk to
      humans.
CI  - Copyright 2010 Elsevier Ltd. All rights reserved.
FAU - Mascolo, Maria Grazia
AU  - Mascolo MG
AD  - Environmental Carcinogenesis and Risk Assessment, Environmental Protection and
      Health Prevention Agency - Emilia-Romagna Region (ER-EPA), Viale Filopanti 22,
      40126 Bologna, Italy.
FAU - Perdichizzi, Stefania
AU  - Perdichizzi S
FAU - Rotondo, Francesca
AU  - Rotondo F
FAU - Morandi, Elena
AU  - Morandi E
FAU - Guerrini, Angela
AU  - Guerrini A
FAU - Silingardi, Paola
AU  - Silingardi P
FAU - Vaccari, Monica
AU  - Vaccari M
FAU - Grilli, Sandro
AU  - Grilli S
FAU - Colacci, Annamaria
AU  - Colacci A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100311
PL  - England
TA  - Toxicol In Vitro
JT  - Toxicology in vitro : an international journal published in association with
      BIBRA
JID - 8712158
RN  - 0 (Carcinogens)
RN  - 0 (Environmental Pollutants)
RN  - 423D2T571U (Ethinyl Estradiol)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - MRK240IY2L (Azathioprine)
RN  - Q41OR9510P (Melphalan)
SB  - IM
MH  - Animals
MH  - Azathioprine/toxicity
MH  - BALB 3T3 Cells
MH  - Carcinogenicity Tests/*methods
MH  - Carcinogens/*toxicity
MH  - Cell Transformation, Neoplastic/*chemically induced
MH  - Environmental Pollutants/toxicity
MH  - Ethinyl Estradiol/toxicity
MH  - Melphalan/toxicity
MH  - Mice
MH  - Polychlorinated Biphenyls/toxicity
EDAT- 2010/03/17 06:00
MHDA- 2010/06/18 06:00
CRDT- 2010/03/16 06:00
PHST- 2009/07/30 00:00 [received]
PHST- 2010/02/26 00:00 [revised]
PHST- 2010/03/07 00:00 [accepted]
PHST- 2010/03/16 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/06/18 06:00 [medline]
AID - S0887-2333(10)00067-6 [pii]
AID - 10.1016/j.tiv.2010.03.003 [doi]
PST - ppublish
SO  - Toxicol In Vitro. 2010 Jun;24(4):1292-300. doi: 10.1016/j.tiv.2010.03.003. Epub
      2010 Mar 11.


PMID- 20226414
OWN - NLM
STAT- MEDLINE
DCOM- 20100722
LR  - 20100315
IS  - 1553-4650 (Print)
IS  - 1553-4650 (Linking)
VI  - 17
IP  - 2
DP  - 2010 Mar-Apr
TI  - Unilateral hydroureteronephrosis after a mesh procedure.
PG  - 232-4
LID - 10.1016/j.jmig.2009.11.014 [doi]
AB  - Synthetic mesh has become a popular treatment of pelvic floor relaxation and
      pelvic organ prolapse, with low complication rates. We describe the case of a
      woman with unilateral hydroureteronephrosis after a mesh procedure (Gynecare
      Prolift; Ethicon Women's Health & Urology, Ethicon, Inc., Somerville, New Jersey)
      successfully treated by neoureterocystostomy. A 39-year-old woman with pelvic
      organ prolapse underwent the mesh procedure. Two months later, she had left flank
      pain, and hydroureteronephrosis was diagnosed on the same side despite
      cystoscopic confirmation of ureteral passage at the first operation. The arm of
      the mesh was removed surgically, and neoureterocystostomy was performed
      successfully. Mesh surgery is not without serious complications, and surgeons
      should bear in mind the possible complications associated with this surgical
      procedure.
CI  - Copyright 2010 AAGL. Published by Elsevier Inc. All rights reserved.
FAU - Karateke, Ates
AU  - Karateke A
AD  - Department of Obstetrics and Gynecology, University of Yeditepe, Bostanci,
      Istanbul, Turkey.
FAU - Cam, Cetin
AU  - Cam C
FAU - Ayaz, Reyhan
AU  - Ayaz R
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Minim Invasive Gynecol
JT  - Journal of minimally invasive gynecology
JID - 101235322
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Hydronephrosis/*diagnosis/*etiology/surgery
MH  - Pelvic Organ Prolapse/*surgery
MH  - Surgical Mesh/*adverse effects
MH  - Ureteral Obstruction/*diagnosis/*etiology/surgery
EDAT- 2010/03/17 06:00
MHDA- 2010/07/23 06:00
CRDT- 2010/03/16 06:00
PHST- 2009/09/12 00:00 [received]
PHST- 2009/11/24 00:00 [revised]
PHST- 2009/11/27 00:00 [accepted]
PHST- 2010/03/16 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/07/23 06:00 [medline]
AID - S1553-4650(09)01256-4 [pii]
AID - 10.1016/j.jmig.2009.11.014 [doi]
PST - ppublish
SO  - J Minim Invasive Gynecol. 2010 Mar-Apr;17(2):232-4. doi:
      10.1016/j.jmig.2009.11.014.


PMID- 20226407
OWN - NLM
STAT- MEDLINE
DCOM- 20100722
LR  - 20100315
IS  - 1553-4650 (Print)
IS  - 1553-4650 (Linking)
VI  - 17
IP  - 2
DP  - 2010 Mar-Apr
TI  - Randomized controlled study comparing the Gynecare Morcellex and Rotocut G1
      tissue morcellators.
PG  - 192-9
LID - 10.1016/j.jmig.2009.11.009 [doi]
AB  - STUDY OBJECTIVE: To evaluate the effectiveness of the Gynecare Morcellex tissue
      morcellator (Ethicon, Inc., Somerville, NJ) in laparoscopic supracervical
      hysterectomy and myomectomy. DESIGN: Randomized controlled trial (Evidence I).
      SETTING: University department of obstetrics and gynecology. PATIENTS:
      Seventy-four patients with symptomatic uterine myomas scheduled for laparoscopic 
      supracervical hysterectomy or myomectomy. INTERVENTIONS: Laparoscopic
      supracervical hysterectomy and myomectomy followed by tissue morcellation using
      the Gynecare Morcellex (experimental group) or the Rotocut G1 morcellator (Karl
      Storz GmbH & Co. KG, Tuttlingen, Germany) (control group). MEASUREMENTS AND MAIN 
      RESULTS: Patient characteristics and surgical data were noted for both groups. No
      difference was detected between groups in any parameters assessed, whereas a
      significant difference (p <.05) in handling score was detected in the
      experimental group compared with the control group. CONCLUSION: The Gynecare
      Morcellex is an effective instrument with excellent safety and handling.
CI  - Copyright 2010 AAGL. Published by Elsevier Inc. All rights reserved.
FAU - Zullo, Fulvio
AU  - Zullo F
AD  - Department of Obstetrics, University Magna Graecia of Catanzaro, Catanzaro,
      Italy.
FAU - Falbo, Angela
AU  - Falbo A
FAU - Iuliano, Assunta
AU  - Iuliano A
FAU - Oppedisano, Rosamaria
AU  - Oppedisano R
FAU - Sacchinelli, Angela
AU  - Sacchinelli A
FAU - Annunziata, Gianluca
AU  - Annunziata G
FAU - Venturella, Roberta
AU  - Venturella R
FAU - Materazzo, Caterina
AU  - Materazzo C
FAU - Tolino, Achille
AU  - Tolino A
FAU - Palomba, Stefano
AU  - Palomba S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - J Minim Invasive Gynecol
JT  - Journal of minimally invasive gynecology
JID - 101235322
SB  - IM
MH  - Adult
MH  - Cost-Benefit Analysis
MH  - Electrosurgery/economics/*instrumentation
MH  - Equipment Design
MH  - Female
MH  - Humans
MH  - Hysterectomy/economics/*instrumentation
MH  - *Laparoscopy
MH  - Leiomyoma/pathology/*surgery
MH  - Middle Aged
MH  - Treatment Outcome
MH  - Tumor Burden
MH  - Uterine Neoplasms/pathology/*surgery
EDAT- 2010/03/17 06:00
MHDA- 2010/07/23 06:00
CRDT- 2010/03/16 06:00
PHST- 2009/07/06 00:00 [received]
PHST- 2009/10/29 00:00 [revised]
PHST- 2009/11/10 00:00 [accepted]
PHST- 2010/03/16 06:00 [entrez]
PHST- 2010/03/17 06:00 [pubmed]
PHST- 2010/07/23 06:00 [medline]
AID - S1553-4650(09)01250-3 [pii]
AID - 10.1016/j.jmig.2009.11.009 [doi]
PST - ppublish
SO  - J Minim Invasive Gynecol. 2010 Mar-Apr;17(2):192-9. doi:
      10.1016/j.jmig.2009.11.009.


PMID- 20225115
OWN - NLM
STAT- MEDLINE
DCOM- 20100617
LR  - 20220410
IS  - 1432-1998 (Electronic)
IS  - 0301-0449 (Linking)
VI  - 40
IP  - 4
DP  - 2010 Apr
TI  - The intersection of ethics and communication in prenatal imaging: challenges for 
      the pediatric radiologist.
PG  - 514-7
LID - 10.1007/s00247-009-1516-y [doi]
AB  - Pediatric radiologists who practice prenatal imaging are often at the front lines
      of communication with pregnant patients and their partners. The communication
      process is particularly complex when a fetal abnormality is diagnosed. Regardless
      of whether the information is completely new and unexpected, or the patient is
      referred for tertiary imaging and counseling, few pediatric radiologists are
      trained specifically in the communication skills necessary to provide optimal
      care to the prospective parents. This paper reviews current literature regarding 
      communication with patients about unexpected or difficult information, and
      illustrates key clinical and ethical features that make conversations with
      pregnant patients particularly challenging in the setting of fetal abnormalities.
FAU - Brown, Stephen D
AU  - Brown SD
AD  - Department of Radiology, Children's Hospital Boston and Harvard Medical School,
      300 Longwood Avenue, Boston, MA 02115, USA. Stephen.brown@childrens.harvard.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Pediatr Radiol
JT  - Pediatric radiology
JID - 0365332
SB  - IM
MH  - Congenital Abnormalities/*diagnosis
MH  - Diagnostic Imaging/*ethics
MH  - Humans
MH  - Physician-Patient Relations/*ethics
MH  - Prenatal Diagnosis/*ethics
MH  - Radiology/*ethics
MH  - United States
RF  - 28
EDAT- 2010/03/13 06:00
MHDA- 2010/06/18 06:00
CRDT- 2010/03/13 06:00
PHST- 2010/03/13 06:00 [entrez]
PHST- 2010/03/13 06:00 [pubmed]
PHST- 2010/06/18 06:00 [medline]
AID - 10.1007/s00247-009-1516-y [doi]
PST - ppublish
SO  - Pediatr Radiol. 2010 Apr;40(4):514-7. doi: 10.1007/s00247-009-1516-y.


PMID- 20224927
OWN - NLM
STAT- MEDLINE
DCOM- 20120209
LR  - 20181113
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 17
IP  - 2
DP  - 2011 Jun
TI  - What values in design? The challenge of incorporating moral values into design.
PG  - 271-87
LID - 10.1007/s11948-010-9198-2 [doi]
AB  - Recently, there is increased attention to the integration of moral values into
      the conception, design, and development of emerging IT. The most reviewed
      approach for this purpose in ethics and technology so far is Value-Sensitive
      Design (VSD). This article considers VSD as the prime candidate for implementing 
      normative considerations into design. Its methodology is considered from a
      conceptual, analytical, normative perspective. The focus here is on the
      suitability of VSD for integrating moral values into the design of technologies
      in a way that joins in with an analytical perspective on ethics of technology.
      Despite its promising character, it turns out that VSD falls short in several
      respects: (1) VSD does not have a clear methodology for identifying stakeholders,
      (2) the integration of empirical methods with conceptual research within the
      methodology of VSD is obscure, (3) VSD runs the risk of committing the
      naturalistic fallacy when using empirical knowledge for implementing values in
      design, (4) the concept of values, as well as their realization, is left
      undetermined and (5) VSD lacks a complimentary or explicit ethical theory for
      dealing with value trade-offs. For the normative evaluation of a technology, I
      claim that an explicit and justified ethical starting point or principle is
      required. Moreover, explicit attention should be given to the value aims and
      assumptions of a particular design. The criteria of adequacy for such an approach
      or methodology follow from the evaluation of VSD as the prime candidate for
      implementing moral values in design.
FAU - Manders-Huits, Noemi
AU  - Manders-Huits N
AD  - Philosophy Section, Delft University of Technology, P.O.Box 5015, 2600 GA, Delft,
      Netherlands. N.L.J.L.Manders-Huits@tudelft.nl
LA  - eng
PT  - Journal Article
DEP - 20100312
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Engineering/*ethics
MH  - *Ethical Analysis
MH  - *Ethical Theory
MH  - Humans
MH  - *Morals
MH  - *Social Values
MH  - Technology/*ethics
PMC - PMC3124645
EDAT- 2010/03/13 06:00
MHDA- 2012/02/10 06:00
CRDT- 2010/03/13 06:00
PHST- 2009/04/02 00:00 [received]
PHST- 2010/02/18 00:00 [accepted]
PHST- 2010/03/13 06:00 [entrez]
PHST- 2010/03/13 06:00 [pubmed]
PHST- 2012/02/10 06:00 [medline]
AID - 10.1007/s11948-010-9198-2 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2011 Jun;17(2):271-87. doi: 10.1007/s11948-010-9198-2. Epub 2010 
      Mar 12.


PMID- 20224537
OWN - NLM
STAT- MEDLINE
DCOM- 20100726
LR  - 20100312
IS  - 1827-1839 (Electronic)
IS  - 0392-9590 (Linking)
VI  - 29
IP  - 1
DP  - 2010 Feb
TI  - Legal and ethical issues in robotic surgery.
PG  - 75-9
AB  - AIM: With the rapid introduction of revolutionary technologies in surgical
      practice, such as computer-enhanced robotic surgery, the complexity in various
      aspects, including medical, legal and ethical, will increase exponentially. Our
      aim was to highlight important legal and ethical implications emerged from the
      application of robotic surgery. METHODS: Search of the pertinent medical and
      legal literature. RESULTS: Robotic surgery may open new avenues in the near
      future in surgical practice. However, in robotic surgery, special training and
      experience along with high quality assessment are required in order to provide
      normal conscientious care and state-of-the-art treatment. While the legal basis
      for professional liability remains exactly the same, litigation with the use of
      robotic surgery may be complex. In case of an undesirable outcome, in addition to
      physician and hospital, the manufacturer of the robotic system may be sued. In
      respect to ethical issues in robotic surgery, equipment safety and reliability,
      provision of adequate information, and maintenance of confidentiality are all of 
      paramount importance. Also, the cost of robotic surgery and the lack of such
      systems in most of the public hospitals may restrict the majority from the
      benefits offered by the new technology. CONCLUSION: While surgical robotics will 
      have a significant impact on surgical practice, it presents challenges so much in
      the realm of law and ethics as of medicine and health care.
FAU - Mavroforou, A
AU  - Mavroforou A
AD  - Department of Medical Law and Ethics, University of Thessaly Medical School,
      Larissa, Greece.
FAU - Michalodimitrakis, E
AU  - Michalodimitrakis E
FAU - Hatzitheo-Filou, C
AU  - Hatzitheo-Filou C
FAU - Giannoukas, A
AU  - Giannoukas A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - Int Angiol
JT  - International angiology : a journal of the International Union of Angiology
JID - 8402693
SB  - IM
MH  - Clinical Competence
MH  - Confidentiality
MH  - Consumer Product Safety
MH  - Equipment Safety
MH  - *Government Regulation
MH  - Health Care Costs
MH  - *Health Policy/economics
MH  - Health Services Accessibility
MH  - Humans
MH  - Informed Consent
MH  - Liability, Legal
MH  - *Robotics/economics/ethics/legislation & jurisprudence
MH  - *Surgery, Computer-Assisted/economics/ethics/legislation & jurisprudence
RF  - 21
EDAT- 2010/03/13 06:00
MHDA- 2010/07/27 06:00
CRDT- 2010/03/13 06:00
PHST- 2010/03/13 06:00 [entrez]
PHST- 2010/03/13 06:00 [pubmed]
PHST- 2010/07/27 06:00 [medline]
AID - R34102329 [pii]
PST - ppublish
SO  - Int Angiol. 2010 Feb;29(1):75-9.


PMID- 20224325
OWN - NLM
STAT- MEDLINE
DCOM- 20100824
LR  - 20100527
IS  - 1536-3708 (Electronic)
IS  - 0148-7043 (Linking)
VI  - 64
IP  - 4
DP  - 2010 Apr
TI  - Tissue thread grafting: nonincisional double-eyelid operation.
PG  - 376-80
LID - 10.1097/SAP.0b013e3181ba5461 [doi]
AB  - Most double-eyelid operations emphasize the levator insertion into the upper
      eyelid skin using suture material. For supratarsal fixation, we used autogenous
      tissue threads from the patients' own temporal fascia, periumbilical tissues,
      capsulopalpebral fascia, and allogeneic human dermis. We engaged tissue threads
      using a newly designed Yeop's needle (AILEE Inc., BuSan, South Korea) or modified
      5-0 Vicryl suture (Ethicon Inc., Somerville, NJ) material. The suture passed
      through the whole upper lid in the same pattern used with the conventional
      nonincisional technique. A total of 78 double-eyelid operations were performed.
      There were 53 primary cases, 22 secondary cases, and 3 tertiary cases. Tissue
      threads were maintained for 9.3 days on average. There were no complications
      regarding tissue threads, including infection or granuloma formation in the upper
      eyelid or at the donor site. Tissue thread grafts not only offer safe fixation of
      the palpebral crease, but they also incorporate safely into the eyelid tissues
      for scarless, natural-looking double-eyelids.
FAU - Choi, Yeop
AU  - Choi Y
AD  - Choi Yeop Plastic Surgery Clinic, Seoul, South Korea.
FAU - Eo, SuRak
AU  - Eo S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Plast Surg
JT  - Annals of plastic surgery
JID - 7805336
RN  - 0 (Alloderm)
RN  - 0 (Biocompatible Materials)
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biocompatible Materials
MH  - Blepharoplasty/*methods
MH  - Blepharoptosis/*surgery
MH  - Collagen
MH  - Eyelids/*surgery
MH  - Female
MH  - Humans
MH  - Male
MH  - *Suture Techniques
MH  - Young Adult
EDAT- 2010/03/13 06:00
MHDA- 2010/08/25 06:00
CRDT- 2010/03/13 06:00
PHST- 2010/03/13 06:00 [entrez]
PHST- 2010/03/13 06:00 [pubmed]
PHST- 2010/08/25 06:00 [medline]
AID - 10.1097/SAP.0b013e3181ba5461 [doi]
PST - ppublish
SO  - Ann Plast Surg. 2010 Apr;64(4):376-80. doi: 10.1097/SAP.0b013e3181ba5461.


PMID- 20224045
OWN - NLM
STAT- MEDLINE
DCOM- 20100518
LR  - 20190722
IS  - 1530-8561 (Electronic)
IS  - 0009-9147 (Linking)
VI  - 56
IP  - 5
DP  - 2010 May
TI  - Mendelian randomization in the era of genomewide association studies.
PG  - 723-8
LID - 10.1373/clinchem.2009.141564 [doi]
AB  - BACKGROUND: Observational epidemiology has been instrumental in identifying
      modifiable causes of common diseases, and, in turn, substantially impacting
      public health. Spurious associations in observational epidemiologic studies are
      most commonly caused by confounding due to social, behavioral, or environmental
      factors and can therefore be difficult to control. They may also be due to
      reverse causation-in which the phenotypic outcome subsequently influences an
      environmental exposure such that it is wrongly implicated in its pathogenesis-and
      selection bias. Randomized controlled trials are effective in dealing with the
      potential sources of error; however, their use is not always leveraged, for
      practical or ethical reasons. CONTENT: An alternative method, mendelian
      randomization, entails the use of genetic variants as proxies for the
      environmental exposures under investigation. The power of mendelian randomization
      lies in its ability to avoid the often substantial confounding seen in
      conventional observational epidemiology. Underpinning mendelian randomization is 
      the principle of the independent assortment of alleles during meiosis, which,
      importantly in this context, also implies that they are independent of those
      behavioral and environmental factors that confound epidemiologic studies. By
      selecting genetic variants that influence exposure patterns or are associated
      with an intermediate phenotype of the disease, one can effectively re-create a
      randomized comparison. SUMMARY: In the past 4 years, genomewide association
      studies have yielded the first robust genetic associations with common diseases, 
      which in turn should enable mendelian randomization to be even more informative, 
      despite some limitations outlined in this review.
FAU - Sleiman, Patrick M A
AU  - Sleiman PM
AD  - Center for Applied Genomics, The Children's Hospital of Philadelphia Research
      Institute, Philadelphia, PA 19104, USA. sleimanp@email.chop.edu
FAU - Grant, Struan F A
AU  - Grant SF
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100311
PL  - England
TA  - Clin Chem
JT  - Clinical chemistry
JID - 9421549
SB  - IM
MH  - Genome-Wide Association Study/trends
MH  - Humans
MH  - Mendelian Randomization Analysis/trends
MH  - Molecular Epidemiology/*trends
RF  - 40
EDAT- 2010/03/13 06:00
MHDA- 2010/05/19 06:00
CRDT- 2010/03/13 06:00
PHST- 2010/03/13 06:00 [entrez]
PHST- 2010/03/13 06:00 [pubmed]
PHST- 2010/05/19 06:00 [medline]
AID - clinchem.2009.141564 [pii]
AID - 10.1373/clinchem.2009.141564 [doi]
PST - ppublish
SO  - Clin Chem. 2010 May;56(5):723-8. doi: 10.1373/clinchem.2009.141564. Epub 2010 Mar
      11.


PMID- 20224026
OWN - NLM
STAT- MEDLINE
DCOM- 20100609
LR  - 20220409
IS  - 1545-7230 (Electronic)
IS  - 1042-9670 (Linking)
VI  - 34
IP  - 2
DP  - 2010 Mar-Apr
TI  - Gender differences in faculty development: a faculty needs survey.
PG  - 136-40
LID - 10.1176/appi.ap.34.2.136 [doi]
AB  - OBJECTIVE: The authors investigated professional development needs of faculty in 
      the Department of Psychiatry and Behavioral Sciences at the University of
      California (UC) Davis, while also exploring any existing differences according to
      gender and academic rank. METHODS: An online survey was sent to 75 faculty
      members, and 41 responses (17 women, 24 men) were collected. Respondents rated 29
      items on a Likert scale, from "very important" to "not important" and ranked the 
      top three items in order of importance. RESULTS: Very important items included
      finding meaning in one's work, maintaining integrity and ethics, maintaining
      one's values and academic vitality, balancing personal and professional demands, 
      a flexible work environment, and preventing and handling burnout. Results were
      similar across gender and rank. CONCLUSION: UC Davis men and women academic
      psychiatrists in different career development stages have similar needs, although
      paths leading to personal and professional fulfillment may vary according to
      gender.
FAU - Seritan, Andreea L
AU  - Seritan AL
AD  - Department of Psychiatry and Behavioral Sciences, UC Davis, Sacramento, CA 95817,
      USA. andreea.seritan@ucdmc.ucdavis.edu
FAU - Iosif, Ana-Maria
AU  - Iosif AM
FAU - Hyvonen, Shelby
AU  - Hyvonen S
FAU - Lan, Mei-Fang
AU  - Lan MF
FAU - Boyum, Kathleen
AU  - Boyum K
FAU - Hilty, Donald
AU  - Hilty D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Acad Psychiatry
JT  - Academic psychiatry : the journal of the American Association of Directors of
      Psychiatric Residency Training and the Association for Academic Psychiatry
JID - 8917200
SB  - IM
MH  - California
MH  - Data Collection/*methods/*statistics & numerical data
MH  - Faculty, Medical/*statistics & numerical data
MH  - Female
MH  - Humans
MH  - Job Satisfaction
MH  - Male
MH  - Personal Satisfaction
MH  - Principal Component Analysis
MH  - Sex Factors
MH  - Staff Development/*methods/*statistics & numerical data
EDAT- 2010/03/13 06:00
MHDA- 2010/06/10 06:00
CRDT- 2010/03/13 06:00
PHST- 2010/03/13 06:00 [entrez]
PHST- 2010/03/13 06:00 [pubmed]
PHST- 2010/06/10 06:00 [medline]
AID - 34/2/136 [pii]
AID - 10.1176/appi.ap.34.2.136 [doi]
PST - ppublish
SO  - Acad Psychiatry. 2010 Mar-Apr;34(2):136-40. doi: 10.1176/appi.ap.34.2.136.


PMID- 20223946
OWN - NLM
STAT- MEDLINE
DCOM- 20100610
LR  - 20111117
IS  - 1538-6724 (Electronic)
IS  - 0031-9023 (Linking)
VI  - 90
IP  - 5
DP  - 2010 May
TI  - The revised APTA code of ethics for the physical therapist and standards of
      ethical conduct for the physical therapist assistant: theory, purpose, process,
      and significance.
PG  - 803-24
LID - 10.2522/ptj.20090373 [doi]
AB  - INTRODUCTION: In June 2009, the House of Delegates (HOD) of the American Physical
      Therapy Association (APTA) passed a major revision of the APTA Code of Ethics for
      physical therapists and the Standards of Ethical Conduct for the Physical
      Therapist Assistant. The revised documents will be effective July 1, 2010.
      PURPOSE: The purposes of this article are: (1) to provide a historical,
      professional, and theoretical context for this important revision; (2) to
      describe the 4-year revision process; (3) to examine major features of the
      documents; and (4) to discuss the significance of the revisions from the
      perspective of the maturation of physical therapy as a doctoring profession.
      PROCESS OF REVISION: The process for revision is delineated within the context of
      history and the Bylaws of APTA. FORMAT, STRUCTURE, AND CONTENT OF REVISED CORE
      ETHICS DOCUMENTS: The revised documents represent a significant change in format,
      level of detail, and scope of application. Previous APTA Codes of Ethics and
      Standards of Ethical Conduct for the Physical Therapist Assistant have delineated
      very broad general principles, with specific obligations spelled out in the
      Ethics and Judicial Committee's Guide for Professional Conduct and Guide for
      Conduct of the Physical Therapist Assistant. In contrast to the current
      documents, the revised documents address all 5 roles of the physical therapist,
      delineate ethical obligations in organizational and business contexts, and align 
      with the tenets of Vision 2020. SIGNIFICANCE: The significance of this revision
      is discussed within historical parameters, the implications for physical
      therapists and physical therapist assistants, the maturation of the profession,
      societal accountability and moral community, potential regulatory implications,
      and the inclusive and deliberative process of moral dialogue by which changes
      were developed, revised, and approved.
FAU - Swisher, Laura Lee
AU  - Swisher LL
AD  - School of Physical Therapy and Rehabilitation Sciences, and Assistant Dean for
      Interprofessional Education, College of Medicine, University of South Florida,
      12901 Bruce B Downs Blvd, MDC 77, Tampa, FL 33612-4766, USA.
      LSwisher@health.usf.edu
FAU - Hiller, Peggy
AU  - Hiller P
CN  - APTA Task Force to Revise the Core Ethics Documents
LA  - eng
PT  - Journal Article
DEP - 20100311
PL  - United States
TA  - Phys Ther
JT  - Physical therapy
JID - 0022623
SB  - IM
MH  - *Codes of Ethics
MH  - Humans
MH  - Physical Therapy Specialty/*ethics
MH  - Societies, Medical
MH  - United States
EDAT- 2010/03/13 06:00
MHDA- 2010/06/11 06:00
CRDT- 2010/03/13 06:00
PHST- 2010/03/13 06:00 [entrez]
PHST- 2010/03/13 06:00 [pubmed]
PHST- 2010/06/11 06:00 [medline]
AID - ptj.20090373 [pii]
AID - 10.2522/ptj.20090373 [doi]
PST - ppublish
SO  - Phys Ther. 2010 May;90(5):803-24. doi: 10.2522/ptj.20090373. Epub 2010 Mar 11.


PMID- 20223784
OWN - NLM
STAT- MEDLINE
DCOM- 20111228
LR  - 20110818
IS  - 1477-0334 (Electronic)
IS  - 0962-2802 (Linking)
VI  - 20
IP  - 4
DP  - 2011 Aug
TI  - A behavioural Bayes approach to the determination of sample size for clinical
      trials considering efficacy and safety: imbalanced sample size in treatment
      groups.
PG  - 389-400
LID - 10.1177/0962280209358131 [doi]
AB  - The behavioural Bayes approach to sample size determination for clinical trials
      assumes that the number of subsequent patients switching to a new drug from the
      current drug depends on the strength of the evidence for efficacy and safety that
      was observed in the clinical trials. The optimal sample size is the one which
      maximises the expected net benefit of the trial. The approach has been developed 
      in a series of papers by Pezeshk and the present authors (Gittins JC, Pezeshk H. 
      A behavioral Bayes method for determining the size of a clinical trial. Drug
      Information Journal 2000; 34: 355-63; Gittins JC, Pezeshk H. How Large should a
      clinical trial be? The Statistician 2000; 49(2): 177-87; Gittins JC, Pezeshk H. A
      decision theoretic approach to sample size determination in clinical trials.
      Journal of Biopharmaceutical Statistics 2002; 12(4): 535-51; Gittins JC, Pezeshk 
      H. A fully Bayesian approach to calculating sample sizes for clinical trials with
      binary responses. Drug Information Journal 2002; 36: 143-50; Kikuchi T, Pezeshk
      H, Gittins J. A Bayesian cost-benefit approach to the determination of sample
      size in clinical trials. Statistics in Medicine 2008; 27(1): 68-82; Kikuchi T,
      Gittins J. A behavioral Bayes method to determine the sample size of a clinical
      trial considering efficacy and safety. Statistics in Medicine 2009; 28(18):
      2293-306; Kikuchi T, Gittins J. A Bayesian procedure for cost-benefit evaluation 
      of a new drug in multi-national clinical trials. Statistics in Medicine 2009
      (Submitted)). The purpose of this article is to provide a rationale for
      experimental designs which allocate more patients to the new treatment than to
      the control group. The model uses a logistic weight function, including an
      interaction term linking efficacy and safety, which determines the number of
      patients choosing the new drug, and hence the resulting benefit. A Monte Carlo
      simulation is employed for the calculation. Having a larger group of patients on 
      the new drug in general makes it easier to recruit patients to the trial and may 
      also be ethically desirable. Our results show that this can be done with very
      little if any reduction in expected net benefit.
FAU - Kikuchi, Takashi
AU  - Kikuchi T
AD  - Department of Statistics, University of Oxford, 1 South Parks Road, Oxford, UK.
      kikuchi@stats.ox.ac.uk
FAU - Gittins, John
AU  - Gittins J
LA  - eng
PT  - Journal Article
DEP - 20100311
PL  - England
TA  - Stat Methods Med Res
JT  - Statistical methods in medical research
JID - 9212457
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
SB  - IM
MH  - *Bayes Theorem
MH  - Clinical Trials, Phase III as Topic/economics/statistics & numerical data
MH  - Computer Simulation/statistics & numerical data
MH  - Decision Theory
MH  - Humans
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage/adverse
      effects
MH  - Logistic Models
MH  - Monte Carlo Method
MH  - Randomized Controlled Trials as Topic/economics/statistics & numerical data
MH  - Research Design/*statistics & numerical data
MH  - *Sample Size
EDAT- 2010/03/13 06:00
MHDA- 2011/12/29 06:00
CRDT- 2010/03/13 06:00
PHST- 2010/03/13 06:00 [entrez]
PHST- 2010/03/13 06:00 [pubmed]
PHST- 2011/12/29 06:00 [medline]
AID - 0962280209358131 [pii]
AID - 10.1177/0962280209358131 [doi]
PST - ppublish
SO  - Stat Methods Med Res. 2011 Aug;20(4):389-400. doi: 10.1177/0962280209358131. Epub
      2010 Mar 11.


PMID- 20223644
OWN - NLM
STAT- MEDLINE
DCOM- 20100803
LR  - 20100426
IS  - 1769-664X (Electronic)
IS  - 0929-693X (Linking)
VI  - 17
IP  - 5
DP  - 2010 May
TI  - [Very premature births: Dilemmas and management. Part 1. Outcome of infants born 
      before 28 weeks of postmenstrual age, and definition of a gray zone].
PG  - 518-26
LID - 10.1016/j.arcped.2009.09.025 [doi]
AB  - With very preterm deliveries, the decision to institute intensive care, or,
      alternatively, to start palliative care and let the baby die, is extremely
      difficult, and involves complex ethical issues. The introduction of intensive
      care may result in long-term survival of many infants without severe
      disabilities, but it may also result in the survival of severely disabled
      infants. Conversely, the decision to withhold resuscitation and/or intensive care
      at birth, which is an option at the margin of viability, implies allowing babies 
      to die, although some of them would have developed normally if they had received 
      resuscitation and/or intensive care. Withholding intensive care at birth does not
      mean withholding care but rather providing palliative care to prevent pain and
      suffering during the time period preceding death. The likelihood of survival
      without significant disabilities decreases as gestational age at birth decreases.
      In addition to gestational age, other factors greatly influence the prognosis.
      Indeed, for a given gestational age, higher birth weight, singleton birth, female
      sex, exposure to prenatal corticosteroids, and birth in a tertiary center are
      favorable factors. Considering gestational age, there is a gray zone that
      corresponds to major prognostic uncertainty and therefore to a major problem in
      making a "good" decision. In France today, the gray zone corresponds to
      deliveries at 24 and 25 weeks of postmenstrual age. In general, babies born above
      the gray zone (26 weeks of postmenstrual age and later) should receive
      resuscitation and/or full intensive care. Below 24 weeks, palliative care is the 
      only option offered in France at the present time. Decisions within the gray zone
      will be addressed in the 2nd part of this work.
CI  - Copyright 2010 Elsevier Masson SAS. All rights reserved.
FAU - Moriette, G
AU  - Moriette G
AD  - Service de medecine neonatale de Port-Royal, 123, boulevard de Port-Royal, 75014 
      Paris, France. guy.moriette@cch.aphp.fr
FAU - Rameix, S
AU  - Rameix S
FAU - Azria, E
AU  - Azria E
FAU - Fournie, A
AU  - Fournie A
FAU - Andrini, P
AU  - Andrini P
FAU - Caeymaex, L
AU  - Caeymaex L
FAU - Dageville, C
AU  - Dageville C
FAU - Gold, F
AU  - Gold F
FAU - Kuhn, P
AU  - Kuhn P
FAU - Storme, L
AU  - Storme L
FAU - Simeoni, U
AU  - Simeoni U
CN  - Groupe de reflexion sur les aspects ethiques de la perinatologie
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Naissances tres prematurees : dilemmes et propositions de prise en charge.
      Premiere partie : pronostic des naissances avant 28 semaines, identification
      d'une zone grise.
DEP - 20100312
PL  - France
TA  - Arch Pediatr
JT  - Archives de pediatrie : organe officiel de la Societe francaise de pediatrie
JID - 9421356
RN  - 0 (Adrenal Cortex Hormones)
SB  - IM
MH  - Adrenal Cortex Hormones/administration & dosage
MH  - Birth Weight
MH  - Brain Damage, Chronic/etiology/mortality
MH  - Child
MH  - Child, Preschool
MH  - Developmental Disabilities/etiology/mortality
MH  - Ethics Committees
MH  - *Ethics, Medical
MH  - Fetal Viability
MH  - Follow-Up Studies
MH  - France
MH  - Gestational Age
MH  - Humans
MH  - Infant
MH  - *Infant, Extremely Low Birth Weight
MH  - Infant, Newborn
MH  - Infant, Premature, Diseases/mortality/*therapy
MH  - Intensive Care, Neonatal/*ethics
MH  - Palliative Care/*ethics
MH  - Prognosis
MH  - Resuscitation/*ethics
MH  - Risk Factors
MH  - Sex Factors
MH  - Survival Rate
RF  - 26
IR  - Altavilla AG
FIR - Altavilla, Anna-Grazia
IR  - Andrini P
FIR - Andrini, Pierre
IR  - Aujard Y
FIR - Aujard, Yannick
IR  - Azria E
FIR - Azria, Elie
IR  - Betremieux P
FIR - Betremieux, Pierre
IR  - Boitias C
FIR - Boitias, Claire
IR  - Caeymaex L
FIR - Caeymaex, Laurence
IR  - Chabernaud JL
FIR - Chabernaud, Jean-Louis
IR  - Collet M
FIR - Collet, Michel
IR  - Dageville C
FIR - Dageville, Christian
IR  - Danan C
FIR - Danan, Claude
IR  - Debillon T
FIR - Debillon, Thierry
IR  - De Dreuzy P
FIR - De Dreuzy, Pascaline
IR  - Dehan M
FIR - Dehan, Michel
IR  - Denizot S
FIR - Denizot, Sophie
IR  - Deruelle P
FIR - Deruelle, Philippe
IR  - Dommergues M
FIR - Dommergues, Marc
IR  - Farnoux C
FIR - Farnoux, Caroline
IR  - Fournie A
FIR - Fournie, Alain
IR  - Gold F
FIR - Gold, Francis
IR  - Gouyon JB
FIR - Gouyon, Jean-Bernard
IR  - Grassin M
FIR - Grassin, Marc
IR  - Guidicelli B
FIR - Guidicelli, Beatrice
IR  - Huillery ML
FIR - Huillery, Marie-Luce
IR  - Jarreau PH
FIR - Jarreau, Pierre-Henri
IR  - Jouannic JM
FIR - Jouannic, Jean-Marie
IR  - Kracher S
FIR - Kracher, Sylvie
IR  - Kuhn P
FIR - Kuhn, Pierre
IR  - Le Coz P
FIR - Le Coz, Pierre
IR  - Lequien P
FIR - Lequien, Pierre
IR  - Mahieu-Caputo D
FIR - Mahieu-Caputo, Dominique
IR  - Moriette G
FIR - Moriette, Guy
IR  - Narcy P
FIR - Narcy, Philippe
IR  - Oriot D
FIR - Oriot, Denis
IR  - Parat S
FIR - Parat, Sophie
IR  - Puech F
FIR - Puech, Francis
IR  - Rameix S
FIR - Rameix, Suzanne
IR  - Ropert JC
FIR - Ropert, Jean-Claude
IR  - Roze JC
FIR - Roze, Jean-Christophe
IR  - Simeoni U
FIR - Simeoni, Umberto
IR  - Storme L
FIR - Storme, Laurent
IR  - Vernier D
FIR - Vernier, Dominique
EDAT- 2010/03/13 06:00
MHDA- 2010/08/04 06:00
CRDT- 2010/03/13 06:00
PHST- 2009/05/27 00:00 [received]
PHST- 2009/09/14 00:00 [accepted]
PHST- 2010/03/13 06:00 [entrez]
PHST- 2010/03/13 06:00 [pubmed]
PHST- 2010/08/04 06:00 [medline]
AID - S0929-693X(10)00044-8 [pii]
AID - 10.1016/j.arcped.2009.09.025 [doi]
PST - ppublish
SO  - Arch Pediatr. 2010 May;17(5):518-26. doi: 10.1016/j.arcped.2009.09.025. Epub 2010
      Mar 12.


PMID- 20223643
OWN - NLM
STAT- MEDLINE
DCOM- 20100803
LR  - 20100426
IS  - 1769-664X (Electronic)
IS  - 0929-693X (Linking)
VI  - 17
IP  - 5
DP  - 2010 May
TI  - [Very premature births: Dilemmas and management. Second part: Ethical aspects and
      recommendations].
PG  - 527-39
LID - 10.1016/j.arcped.2009.09.024 [doi]
AB  - In the first part of this work, the outcome following very premature birth was
      assessed. This enabled a gray zone to be defined, with inherent major prognostic 
      uncertainty. In France today, the gray zone corresponds to deliveries occurring
      at 24 and 25 weeks of postmenstrual age. The management of births occurring below
      and above the gray zone was described. Withholding intensive care at birth for
      babies born below or within the gray zone does not mean withholding care but
      rather providing palliative care to prevent pain and suffering during the time
      period preceding death. Given the high level of uncertainty, making good
      decisions within the gray zone is problematic. Decisions should be based on the
      infant's best interests. Decisions should be reached with the parents, who are
      entitled to receive clear and comprehensive information. Possible decisions to
      withhold intensive care should be made following the procedures described in the 
      French law of April 2005. Guidelines, based on gestational age and the other
      prognostic elements, are proposed to the parents before birth. They are applied
      in an individualized fashion, in order to take into account the individual
      features of each case. At 25 weeks, resuscitation and/or full intensive care are 
      usually proposed, unless unfavorable factors, such as severe growth restriction, 
      are associated. A senior neonatologist will attend the delivery and will make
      decisions based on both the baby's condition at birth and the parents' wishes. At
      24 weeks, in the absence of unfavorable associated factors, the parents' wishes
      should be followed in deciding between initiating full intensive care or
      palliative care. Below 24 weeks, palliative care is the only option to be offered
      in France at the present time.
CI  - Copyright 2010 Elsevier Masson SAS. All rights reserved.
FAU - Moriette, G
AU  - Moriette G
AD  - Service de medecine neonatale de Port-Royal, 123, boulevard de Port-Royal, 75 014
      Paris, France. guy.moriette@cch.aphp.fr
FAU - Rameix, S
AU  - Rameix S
FAU - Azria, E
AU  - Azria E
FAU - Fournie, A
AU  - Fournie A
FAU - Andrini, P
AU  - Andrini P
FAU - Caeymaex, L
AU  - Caeymaex L
FAU - Dageville, C
AU  - Dageville C
FAU - Gold, F
AU  - Gold F
FAU - Kuhn, P
AU  - Kuhn P
FAU - Storme, L
AU  - Storme L
FAU - Simeoni, U
AU  - Simeoni U
CN  - Groupe de reflexion sur les aspects ethiques de la perinatologie
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Naissances tres prematurees : dilemmes et propositions de prise en charge.
      Seconde partie : enjeux ethiques, principes de prise en charge et
      recommandations.
DEP - 20100312
PL  - France
TA  - Arch Pediatr
JT  - Archives de pediatrie : organe officiel de la Societe francaise de pediatrie
JID - 9421356
SB  - IM
MH  - Decision Making
MH  - Ethics Committees/legislation & jurisprudence
MH  - *Ethics, Medical
MH  - Fetal Viability
MH  - France
MH  - Gestational Age
MH  - Guideline Adherence/ethics/legislation & jurisprudence
MH  - Humans
MH  - *Infant, Extremely Low Birth Weight
MH  - Infant, Newborn
MH  - Infant, Premature, Diseases/mortality/*therapy
MH  - Intensive Care, Neonatal/*ethics
MH  - Palliative Care/*ethics/legislation & jurisprudence
MH  - Professional-Family Relations/ethics
MH  - Prognosis
MH  - Resuscitation/*ethics
MH  - Resuscitation Orders/ethics/legislation & jurisprudence
MH  - Withholding Treatment/ethics/legislation & jurisprudence
IR  - Altavilla AG
FIR - Altavilla, Anna-Grazia
IR  - Andrini P
FIR - Andrini, Pierre
IR  - Aujard Y
FIR - Aujard, Yannick
IR  - Azria E
FIR - Azria, Elie
IR  - Betremieux P
FIR - Betremieux, Pierre
IR  - Boitias C
FIR - Boitias, Claire
IR  - Chabernaud JL
FIR - Chabernaud, Jean-Louis
IR  - Collet M
FIR - Collet, Michel
IR  - Dageville C
FIR - Dageville, Christian
IR  - Danan C
FIR - Danan, Claude
IR  - Debillon T
FIR - Debillon, Thierry
IR  - De Dreuzy P
FIR - De Dreuzy, Pascaline
IR  - Dehan M
FIR - Dehan, Michel
IR  - Denizot S
FIR - Denizot, Sophie
IR  - Deruelle P
FIR - Deruelle, Philippe
IR  - Dommergues M
FIR - Dommergues, Marc
IR  - Farnoux C
FIR - Farnoux, Caroline
IR  - Fournie A
FIR - Fournie, Alain
IR  - Gold F
FIR - Gold, Francis
IR  - Gouyon JB
FIR - Gouyon, Jean-Bernard
IR  - Grassin M
FIR - Grassin, Marc
IR  - Guidicelli B
FIR - Guidicelli, Beatrice
IR  - Huillery ML
FIR - Huillery, Marie-Luce
IR  - Jarreau PH
FIR - Jarreau, Pierre-Henri
IR  - Jouannic JM
FIR - Jouannic, Jean-Marie
IR  - Kracher S
FIR - Kracher, Sylvie
IR  - Kuhn P
FIR - Kuhn, Pierre
IR  - Le Coz P
FIR - Le Coz, Pierre
IR  - Lequien P
FIR - Lequien, Pierre
IR  - Mahieu-Caputo D
FIR - Mahieu-Caputo, Dominique
IR  - Moriette G
FIR - Moriette, Guy
IR  - Narcy P
FIR - Narcy, Philippe
IR  - Oriot D
FIR - Oriot, Denis
IR  - Parat S
FIR - Parat, Sophie
IR  - Puech F
FIR - Puech, Francis
IR  - Rameix S
FIR - Rameix, Suzanne
IR  - Ropert JC
FIR - Ropert, Jean-Claude
IR  - Roze JC
FIR - Roze, Jean-Christophe
IR  - Simeoni U
FIR - Simeoni, Umberto
IR  - Storme L
FIR - Storme, Laurent
IR  - Vernier D
FIR - Vernier, Dominique
EDAT- 2010/03/13 06:00
MHDA- 2010/08/04 06:00
CRDT- 2010/03/13 06:00
PHST- 2009/05/27 00:00 [received]
PHST- 2009/09/15 00:00 [accepted]
PHST- 2010/03/13 06:00 [entrez]
PHST- 2010/03/13 06:00 [pubmed]
PHST- 2010/08/04 06:00 [medline]
AID - S0929-693X(10)00043-6 [pii]
AID - 10.1016/j.arcped.2009.09.024 [doi]
PST - ppublish
SO  - Arch Pediatr. 2010 May;17(5):527-39. doi: 10.1016/j.arcped.2009.09.024. Epub 2010
      Mar 12.


PMID- 20223506
OWN - NLM
STAT- MEDLINE
DCOM- 20100603
LR  - 20101213
IS  - 1527-9995 (Electronic)
IS  - 0090-4295 (Linking)
VI  - 75
IP  - 5
DP  - 2010 May
TI  - Better short-term outcomes with the U-method compared with the Hammock technique 
      for the implantation of the TVT-SECUR under local anesthesia.
PG  - 1060-4
LID - 10.1016/j.urology.2009.11.071 [doi]
AB  - OBJECTIVES: To observe the satisfaction of local anesthesia during the
      implantation of the tension-free vaginal tape (TVT)-SECUR (Gynecare, Ethicon,
      Somerville, NJ) for the treatment of stress urinary incontinence, using
      questionnaires completed by the patients, and to evaluate the short-term safety
      and efficacy of the sling. METHODS: Forty-eight women were operated between
      January 2007 and October 2008. The implantation of the TVT-SECUR was done under
      local anesthesia by 1 surgeon. The "Hammock" technique was used in the first 23
      patients and the "U-Method" in the last 25 patients. RESULTS: Mean patient age
      was 61 years (range, 38-85). Visual analogue scale for pain immediately and 1
      week after surgery showed a mean score of 19/100 and 29/100, respectively.
      Overall, 93% (43/46) of the patients would recommend this type of anesthesia. At 
      1 week, 2 months, and 6 months after surgery, the improvement in incontinence
      symptoms rate was 82% (18/22), 76% (16/21), and 69% (11/16) for the Hammock
      technique, compared with 75% (18/24), 92% (22/24), and 100% (22/22) for the
      U-Method. At 6 months, the difference was statistically significant (P = .0087). 
      Postoperative complications included 6 partial tape exposures, all with the
      Hammock technique. CONCLUSIONS: Local anesthesia with light sedation represents
      an appropriate choice for the implantation of this new sling. The TVT-SECUR using
      the U-Method appears to be relatively safe, and the short-term efficacy rates
      seem to compare with traditional midurethral slings, with long-term efficacy
      still to be determined. This is the first report showing better outcomes of one
      technique over the other.
CI  - Crown Copyright 2010. Published by Elsevier Inc. All rights reserved.
FAU - Gagnon, Louis-Olivier
AU  - Gagnon LO
AD  - Service d'Urologie, Centre Hospitalier universitaire de Sherbrooke (CHUS),
      Universite de Sherbrooke, Quebec, Canada. louis.olivier.gagnon@gmail.com
FAU - Tu, Le Mai
AU  - Tu le M
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100312
PL  - United States
TA  - Urology
JT  - Urology
JID - 0366151
SB  - IM
CIN - Urology. 2010 May;75(5):1064. PMID: 20451716
CIN - Urology. 2010 Nov;76(5):1271. PMID: 21056280
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Anesthesia, Local
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - *Patient Satisfaction
MH  - Prospective Studies
MH  - Prosthesis Implantation/*methods
MH  - *Suburethral Slings
MH  - Time Factors
MH  - Treatment Outcome
MH  - Urinary Incontinence, Stress/*surgery
EDAT- 2010/03/13 06:00
MHDA- 2010/06/04 06:00
CRDT- 2010/03/13 06:00
PHST- 2009/09/08 00:00 [received]
PHST- 2009/11/11 00:00 [revised]
PHST- 2009/11/21 00:00 [accepted]
PHST- 2010/03/13 06:00 [entrez]
PHST- 2010/03/13 06:00 [pubmed]
PHST- 2010/06/04 06:00 [medline]
AID - S0090-4295(10)00004-X [pii]
AID - 10.1016/j.urology.2009.11.071 [doi]
PST - ppublish
SO  - Urology. 2010 May;75(5):1060-4. doi: 10.1016/j.urology.2009.11.071. Epub 2010 Mar
      12.


PMID- 20222278
OWN - NLM
STAT- MEDLINE
DCOM- 20100407
LR  - 20100312
IS  - 1351-5578 (Print)
IS  - 1351-5578 (Linking)
VI  - 17
IP  - 2
DP  - 2010
TI  - Making research supervision work for you.
PG  - 44-51
AB  - Doctoral students face a number of challenges during research. Guidance and
      support is provided through research supervision. However, an individual new to
      the process may find identifying an appropriate supervisor difficult and be
      unaware of strategies that can be employed to make the most out of the process.
      This paper outlines the characteristics of doctoral research supervision and the 
      minimum standards required in the United Kingdom. I will present practical
      strategies gleaned from my experience as a student and doctoral supervisor, along
      with potential ethical issues relating to doctoral supervision. The intention is 
      to enable doctoral students to have the confidence, knowledge and skills to
      enhance their supervision experience and increase the chance of doctoral success.
FAU - Lee, Nancy-Jane
AU  - Lee NJ
AD  - Centre for Nursing and Midwifery Research, School of Nursing and Midwifery,
      University of Salford, UK.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurse Res
JT  - Nurse researcher
JID - 9435953
MH  - Education, Nursing, Graduate/*ethics/*standards
MH  - Faculty, Nursing/*standards
MH  - Humans
MH  - *Interprofessional Relations
MH  - *Nursing Methodology Research
EDAT- 2010/03/13 06:00
MHDA- 2010/04/08 06:00
CRDT- 2010/03/13 06:00
PHST- 2010/03/13 06:00 [entrez]
PHST- 2010/03/13 06:00 [pubmed]
PHST- 2010/04/08 06:00 [medline]
AID - 10.7748/nr2010.01.17.2.44.c7461 [doi]
PST - ppublish
SO  - Nurse Res. 2010;17(2):44-51. doi: 10.7748/nr2010.01.17.2.44.c7461.


PMID- 20222264
OWN - NLM
STAT- MEDLINE
DCOM- 20100330
LR  - 20100312
IS  - 8755-0229 (Print)
IS  - 8755-0229 (Linking)
VI  - 25
IP  - 4
DP  - 2010 Jan-Feb
TI  - Reducing theft and embezzlement by encouraging ethical behavior.
PG  - 251-3
AB  - Medical practices are often faced with employee embezzlement and theft. To
      protect themselves and their practices, physicians should have in place policies 
      and procedures for identifying and handling unethical behaviors by employees.
      This article will deal with the need to set guidelines for what is considered
      ethical and professional conduct in the office.
FAU - Weinstock, Donna
AU  - Weinstock D
AD  - Office Management Solution, 490 Banyan Drive, Northbrook, IL 60062, USA.
      donna@officemanagementsolution.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Med Pract Manage
JT  - The Journal of medical practice management : MPM
JID - 8605494
MH  - Humans
MH  - *Motivation
MH  - Organizational Policy
MH  - *Practice Management, Medical
MH  - Theft/*ethics/*prevention & control
EDAT- 2010/03/13 06:00
MHDA- 2010/03/31 06:00
CRDT- 2010/03/13 06:00
PHST- 2010/03/13 06:00 [entrez]
PHST- 2010/03/13 06:00 [pubmed]
PHST- 2010/03/31 06:00 [medline]
PST - ppublish
SO  - J Med Pract Manage. 2010 Jan-Feb;25(4):251-3.


PMID- 20222121
OWN - NLM
STAT- MEDLINE
DCOM- 20100706
LR  - 20100407
IS  - 1097-4679 (Electronic)
IS  - 0021-9762 (Linking)
VI  - 66
IP  - 5
DP  - 2010 May
TI  - Ethical challenges of practicing in rural areas.
PG  - 537-48
LID - 10.1002/jclp.20681 [doi]
AB  - Mental health professionals practicing in rural areas face ethical dilemmas
      different from those experienced by their urban counterparts and may find that
      the existing ethics literature and American Psychological Association (APA, 2002)
      ethics code not particularly helpful. We highlight parts of five standards from
      the APA ethics code to illustrate the dilemmas rural practitioners frequently
      confront and offer suggestions for how to handle them. We discuss competence,
      human relations, and confidentiality as specific areas and then examine
      assessment and therapy as broader situations in which dilemmas may occur. We use 
      case examples to highlight complications that may arise in rural areas.
CI  - (c) 2010 Wiley Periodicals, Inc.
FAU - Werth, James L Jr
AU  - Werth JL Jr
AD  - Department of Psychology, Radford University, Radford, VA 24142, USA.
      jwerth@radford.edu
FAU - Hastings, Sarah L
AU  - Hastings SL
FAU - Riding-Malon, Ruth
AU  - Riding-Malon R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Psychol
JT  - Journal of clinical psychology
JID - 0217132
SB  - IM
MH  - Anorexia Nervosa/psychology/therapy
MH  - Anxiety Disorders/psychology/therapy
MH  - Confidentiality
MH  - Cooperative Behavior
MH  - Depressive Disorder/psychology/therapy
MH  - *Ethics, Professional
MH  - Humans
MH  - Informed Consent/ethics
MH  - Interdisciplinary Communication
MH  - Mental Disorders/psychology/*therapy
MH  - Mental Health Services/*ethics
MH  - Professional Competence
MH  - Professional-Patient Relations
MH  - Referral and Consultation/ethics
MH  - Rural Health Services/*ethics
MH  - Social Environment
MH  - United States
EDAT- 2010/03/12 06:00
MHDA- 2010/07/07 06:00
CRDT- 2010/03/12 06:00
PHST- 2010/03/12 06:00 [entrez]
PHST- 2010/03/12 06:00 [pubmed]
PHST- 2010/07/07 06:00 [medline]
AID - 10.1002/jclp.20681 [doi]
PST - ppublish
SO  - J Clin Psychol. 2010 May;66(5):537-48. doi: 10.1002/jclp.20681.


PMID- 20222018
OWN - NLM
STAT- MEDLINE
DCOM- 20100520
LR  - 20100420
IS  - 1545-5017 (Electronic)
IS  - 1545-5009 (Linking)
VI  - 54
IP  - 7
DP  - 2010 Jul 1
TI  - When is state intervention justified? An ethics consult gone bad.
PG  - 1054; author reply 1055
LID - 10.1002/pbc.22441 [doi]
FAU - Wells, Robert J
AU  - Wells RJ
LA  - eng
PT  - Comment
PT  - Letter
PL  - United States
TA  - Pediatr Blood Cancer
JT  - Pediatric blood & cancer
JID - 101186624
SB  - IM
CON - Pediatr Blood Cancer. 2010 Jan;54(1):8-10. PMID: 19902558
MH  - Anemia, Sickle Cell/*therapy
MH  - Blood Transfusion/*ethics
MH  - *Ethics, Medical
MH  - Humans
MH  - *Religion
MH  - *State Government
EDAT- 2010/03/12 06:00
MHDA- 2010/05/21 06:00
CRDT- 2010/03/12 06:00
PHST- 2010/03/12 06:00 [entrez]
PHST- 2010/03/12 06:00 [pubmed]
PHST- 2010/05/21 06:00 [medline]
AID - 10.1002/pbc.22441 [doi]
PST - ppublish
SO  - Pediatr Blood Cancer. 2010 Jul 1;54(7):1054; author reply 1055. doi:
      10.1002/pbc.22441.


PMID- 20221859
OWN - NLM
STAT- MEDLINE
DCOM- 20100810
LR  - 20131121
IS  - 1496-8975 (Electronic)
IS  - 0832-610X (Linking)
VI  - 57
IP  - 6
DP  - 2010 Jun
TI  - No change in impedance upon intravascular injection of D5W.
PG  - 559-64
LID - 10.1007/s12630-010-9293-5 [doi]
AB  - PURPOSE: Electrical impedance increases following test injections of
      non-conducting solutions around nerves; however, this increase should diminish
      rapidly with intravascular needle placement, wherein the systemic circulation
      will dissipate the solution. For this observational study, we hypothesized that
      the impedance increases significantly at the perineural space after an injection 
      of 5% dextrose in water (D5W), but that it does not increase correspondingly at
      the intravascular location METHODS: After Ethics Research Board approval,
      electrical impedance was measured by a nerve stimulator displaying resistance,
      Stimuplex HNS 12, before and during (30 sec) an injection of D5W 3 mL: 1) during 
      intravenous cannula placement using an insulated stimulating needle sheathed in
      its plastic cannula, MultiSet NanoLine with 18G needle; and 2) during needle
      placement (Pajunk 22G insulated) for an ultrasound-guided supraclavicular block
      in patients undergoing hand surgery. The impedance changes at each location were 
      analyzed and compared. RESULTS: Data were collected from 16 patients. Baseline
      impedance was lower intravascularly (mean 16.5 +/- standard deviation 7.2 kOmega)
      compared with perineurally (23.5 +/- 8.3 kOmega) (P = 0.037). Peak impedance
      after intravascular D5W injection was 20.1 +/- 6.8 kOmega, which was not a
      significant change (P = 0.15). In contrast, peak impedance after perineural D5W
      injection was 58.6 +/- 29.1 kOmega, an increase of 35.1 +/- 26.4 kOmega (155 +/- 
      117%), and then it reached a plateau of 36.7 +/- 19.6 kOmega. The increase in
      impedance was significantly greater at the perineural location (P < 0.0001).
      CONCLUSION: The absence of a significant increase in impedance upon injection of 
      D5W prior to injection of local anesthetic may provide useful information to warn
      of intravascular injection.
FAU - Chin, James
AU  - Chin J
AD  - Department of Anesthesiology and Pain Medicine, University of Alberta, Edmonton, 
      Canada.
FAU - Tsui, Ban C H
AU  - Tsui BC
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100311
PL  - United States
TA  - Can J Anaesth
JT  - Canadian journal of anaesthesia = Journal canadien d'anesthesie
JID - 8701709
RN  - 0 (Anesthetics, Local)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anesthetics, Local/*administration & dosage
MH  - Electric Impedance
MH  - Electric Stimulation/*methods
MH  - Female
MH  - Glucose/*administration & dosage
MH  - Hand/surgery
MH  - Humans
MH  - Male
MH  - Needles
MH  - Nerve Block/*methods
MH  - Ultrasonography, Interventional
MH  - Young Adult
EDAT- 2010/03/12 06:00
MHDA- 2010/08/11 06:00
CRDT- 2010/03/12 06:00
PHST- 2009/10/09 00:00 [received]
PHST- 2010/02/24 00:00 [accepted]
PHST- 2010/03/12 06:00 [entrez]
PHST- 2010/03/12 06:00 [pubmed]
PHST- 2010/08/11 06:00 [medline]
AID - 10.1007/s12630-010-9293-5 [doi]
PST - ppublish
SO  - Can J Anaesth. 2010 Jun;57(6):559-64. doi: 10.1007/s12630-010-9293-5. Epub 2010
      Mar 11.


PMID- 20221716
OWN - NLM
STAT- MEDLINE
DCOM- 20100921
LR  - 20200928
IS  - 2629-3277 (Electronic)
IS  - 2629-3277 (Linking)
VI  - 6
IP  - 2
DP  - 2010 Jun
TI  - Probing stemness and neural commitment in human amniotic fluid cells.
PG  - 199-214
LID - 10.1007/s12015-010-9116-7 [doi]
AB  - Recently, human amniotic fluid (AF) cells have attracted a great deal of
      attention as an alternative cell source for transplantation and tissue
      engineering. AF contains a variety of cell types derived from fetal tissues, of
      which a small percentage is believed to represent stem cell sub-population(s). In
      contrast to human embryonic stem (ES) cells, AF cells are not subject to
      extensive legal or ethical considerations; nor are they limited by lineage
      commitment characteristic of adult stem cells. However, to become therapeutically
      valuable, better protocols for the isolation of AF stem cell sub-populations need
      to be developed. This study was designed to examine the molecular components
      involved in self-renewal, neural commitment and differentiation of AF cells
      obtained at different gestational ages. Our results showed that, although
      morphologically heterogeneous, AF cells derived from early gestational periods
      ubiquitously expressed KERATIN 8 (K8), suggesting that the majority of these
      cells may have an epithelial origin. In addition, AF cells expressed various
      components of NOTCH signaling (ligands, receptors and target genes), a pathway
      involved in stem cell maintenance, determination and differentiation. A
      sub-population of K8 positive cells (<10%) co-expressed NESTIN, a marker detected
      in the neuroepithelium, neural stem cells and neural progenitors. Throughout the 
      gestational periods, a much smaller AF cell sub-population (<1%) expressed
      pluripotency markers, OCT4a, NANOG and SOX2, from which SOX2 positive AF cells
      could be isolated through single cell cloning. The SOX2 expressing AF clones
      showed the capacity to give rise to a neuron-like phenotype in culture,
      expressing neuronal markers such as MAP2, NFL and NSE. Taken together, our
      findings demonstrated the presence of fetal cells with stem cell characteristics 
      in the amniotic fluid, highlighting the need for further research on their
      biology and clinical applications.
FAU - Jezierski, Anna
AU  - Jezierski A
AD  - Neurogenesis and Brain Repair, Neurobiology Program, Institute for Biological
      Sciences, National Research Council Canada, 1200 Montreal Road, Ottawa, Canada.
FAU - Gruslin, Andree
AU  - Gruslin A
FAU - Tremblay, Roger
AU  - Tremblay R
FAU - Ly, Dao
AU  - Ly D
FAU - Smith, Cathie
AU  - Smith C
FAU - Turksen, Kursad
AU  - Turksen K
FAU - Sikorska, Marianna
AU  - Sikorska M
FAU - Bani-Yaghoub, Mahmud
AU  - Bani-Yaghoub M
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Stem Cell Rev Rep
JT  - Stem cell reviews and reports
JID - 101752767
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Intermediate Filament Proteins)
RN  - 0 (Keratin-8)
RN  - 0 (NANOG protein, human)
RN  - 0 (NES protein, human)
RN  - 0 (Nanog Homeobox Protein)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Nestin)
RN  - 0 (Octamer Transcription Factor-3)
RN  - 0 (POU5F1 protein, human)
RN  - 0 (SOX2 protein, human)
RN  - 0 (SOXB1 Transcription Factors)
SB  - IM
MH  - Amniotic Fluid/*cytology
MH  - Blotting, Western
MH  - Cell Differentiation/genetics/physiology
MH  - Cell Line
MH  - Cells, Cultured
MH  - Female
MH  - Flow Cytometry
MH  - Homeodomain Proteins/genetics/metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Intermediate Filament Proteins/genetics/metabolism
MH  - Keratin-8/genetics/metabolism
MH  - Models, Biological
MH  - Nanog Homeobox Protein
MH  - Nerve Tissue Proteins/genetics/metabolism
MH  - Nestin
MH  - Octamer Transcription Factor-3/genetics/metabolism
MH  - Pregnancy
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - SOXB1 Transcription Factors/genetics/metabolism
MH  - Signal Transduction
MH  - Stem Cells/*cytology/*metabolism
EDAT- 2010/03/12 06:00
MHDA- 2010/09/23 06:00
CRDT- 2010/03/12 06:00
PHST- 2010/03/12 06:00 [entrez]
PHST- 2010/03/12 06:00 [pubmed]
PHST- 2010/09/23 06:00 [medline]
AID - 10.1007/s12015-010-9116-7 [doi]
PST - ppublish
SO  - Stem Cell Rev Rep. 2010 Jun;6(2):199-214. doi: 10.1007/s12015-010-9116-7.


PMID- 20221713
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20181113
IS  - 1826-6983 (Electronic)
IS  - 0033-8362 (Linking)
VI  - 115
IP  - 5
DP  - 2010 Aug
TI  - Myocardial delayed enhancement using a single dose (0.1 mmol/kg) of gadobenate
      dimeglumine: contrast resolution versus intraventricular blood and viable
      myocardium.
PG  - 693-701
LID - 10.1007/s11547-010-0495-2 [doi]
AB  - PURPOSE: This study was done to estimate delayed enhancement (DE) contrast
      resolution of infarcted myocardium (IM) relative to intraventricular blood (IB)
      and viable myocardium (VM) using gadobenate dimeglumine (Gd-BOPTA). MATERIALS AND
      METHODS: After approval from the Ethics Committee, we retrospectively evaluated
      21 consecutive patients (61+/-10 years) with a healed myocardial infarction who
      underwent 1.5-T magnetic resonance (MR) imaging using an
      inversion-recovery-prepared turbo gradient-echo sequence 10 minutes after
      injection of 0.1 mmol/kg of Gd-BOPTA. Signal intensity (SI) was measured in
      arbitrary units (au) for IM, IB, VM, and outside the patient. Contrast-to-noise
      ratio (CNR) was calculated for IM to IB and IM to VM. Seven consecutive patients 
      (59+/-6 years) with a healed myocardial infarction studied with similar technique
      but with 0.1 mmol/kg of gadoterate meglumine (Gd-DOTA) served as the control
      group. The Mann-Whitney U test was used to compare groups. RESULTS: Mean SI of IM
      was 44+/-16 au for Gd-BOPTA and 20+/-6 au for Gd-DOTA (p<0.001), that of IB
      35+/-15 au and 14+/-5 au (p=0.016), and that of VM 7+/-3 au and 5+/-2 au
      (p=0.116), respectively. Mean IM to IB CNR was 10+/-7 for Gd-BOPTA and 8+/-5 for 
      Gd-DOTA (p=0.836), that of IM to VM was 45+/-27 and 18+/-6, respectively
      (p=0.012). CONCLUSIONS: Gd-BOPTA at 0.1 mmol/kg produced a higher myocardial DE
      and an IM to VM CNR than a single dose of Gd-DOTA. No significant difference was 
      observed for IM to IB CNR.
FAU - Papini, G D E
AU  - Papini GD
AD  - Dipartimento di Scienze Medico-Chirurgiche, IRCCS Policlinico San Donato,
      Servizio di Radiologia, Universita degli Studi di Milano, Via Morandi 30, 20097
      San Donato Milanese, Milano, Italy.
FAU - Tritella, S
AU  - Tritella S
FAU - Secchi, F
AU  - Secchi F
FAU - Aliprandi, A
AU  - Aliprandi A
FAU - Di Leo, G
AU  - Di Leo G
FAU - Sardanelli, F
AU  - Sardanelli F
LA  - eng
LA  - ita
PT  - Journal Article
DEP - 20100309
PL  - Italy
TA  - Radiol Med
JT  - La Radiologia medica
JID - 0177625
RN  - 0 (Contrast Media)
RN  - 0 (Heterocyclic Compounds)
RN  - 0 (Organometallic Compounds)
RN  - 15G12L5X8K (gadobenic acid)
RN  - 6HG8UB2MUY (Meglumine)
RN  - 99J2XUF1JT (gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate)
SB  - IM
MH  - Contrast Media/*administration & dosage
MH  - Female
MH  - Heterocyclic Compounds/*administration & dosage
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Meglumine/administration & dosage/*analogs & derivatives
MH  - Middle Aged
MH  - Myocardial Infarction/*pathology
MH  - Organometallic Compounds/*administration & dosage
MH  - Retrospective Studies
MH  - Statistics, Nonparametric
EDAT- 2010/03/12 06:00
MHDA- 2010/09/16 06:00
CRDT- 2010/03/12 06:00
PHST- 2008/12/11 00:00 [received]
PHST- 2009/06/26 00:00 [accepted]
PHST- 2010/03/12 06:00 [entrez]
PHST- 2010/03/12 06:00 [pubmed]
PHST- 2010/09/16 06:00 [medline]
AID - 10.1007/s11547-010-0495-2 [doi]
PST - ppublish
SO  - Radiol Med. 2010 Aug;115(5):693-701. doi: 10.1007/s11547-010-0495-2. Epub 2010
      Mar 9.


PMID- 20221269
OWN - NLM
STAT- MEDLINE
DCOM- 20100617
LR  - 20181113
IS  - 1866-0452 (Electronic)
IS  - 1866-0452 (Linking)
VI  - 107
IP  - 7
DP  - 2010 Feb
TI  - Deep brain stimulation for psychiatric disorders.
PG  - 105-13
LID - 10.3238/arztebl.2010.0105 [doi]
AB  - BACKGROUND: Deep brain stimulation (DBS), an established treatment for some
      movement disorders, is now being used experimentally to treat psychiatric
      disorders as well. In a number of recently published case series, DBS yielded an 
      impressive therapeutic benefit in patients with medically intractable psychiatric
      diseases. METHODS: This review of the use of DBS to treat psychiatric disorders
      is based on literature retrieved from a selective Pubmed search for relevant
      keywords, reference works on the topic, and the authors' own research. RESULTS:
      Studies have been performed on the use of DBS to treat medically intractable
      obsessive-compulsive disorder, depressive disorders, and Tourette syndrome. The
      case numbers in the cited publications were small, yet at least some of them
      involved a methodologically sound investigation. Thus, in some studies, the
      strength of the effect was controlled with a double-blinded interval in which the
      stimulation was turned off. In general, the primary symptoms were found to
      improve markedly, by 35% to 70%, although not all patients responded to the
      treatment. Adverse effects of DBS were very rare in most studies and could
      usually be reversed by changing the stimulation parameters. CONCLUSIONS: The
      results of DBS for psychiatric disorders that have been published to date are
      encouraging. They open up a new perspective in the treatment of otherwise
      intractable disorders. Nonetheless, the efficacy, mechanism of action, and
      adverse effects of DBS for this indication still need to be further studied in
      methodologically adequate trials that meet the highest ethical standard.
FAU - Kuhn, Jens
AU  - Kuhn J
AD  - Klinik fur Psychiatrie und Psychotherapie, Klinikum der Universitat zu Koln,
      Germany. Jens.Kuhn@uk-koeln.de
FAU - Grundler, Theo O J
AU  - Grundler TO
FAU - Lenartz, Doris
AU  - Lenartz D
FAU - Sturm, Volker
AU  - Sturm V
FAU - Klosterkotter, Joachim
AU  - Klosterkotter J
FAU - Huff, Wolfgang
AU  - Huff W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100219
PL  - Germany
TA  - Dtsch Arztebl Int
JT  - Deutsches Arzteblatt international
JID - 101475967
SB  - IM
CIN - Dtsch Arztebl Int. 2010 Feb;107(7):103-4. PMID: 20221268
CIN - Dtsch Arztebl Int. 2010 Sep;107(37):644; author reply 645-6. PMID: 20959892
CIN - Dtsch Arztebl Int. 2010 Sep;107(37):644; author reply 645-6. PMID: 20959893
CIN - Dtsch Arztebl Int. 2010 Sep;107(37):645; author reply 645-6. PMID: 20959894
MH  - Biomedical Research/*trends
MH  - Deep Brain Stimulation/*adverse effects/*trends
MH  - Humans
MH  - Mental Disorders/*prevention & control
MH  - Nervous System Diseases/*etiology/*prevention & control
RF  - 82
PMC - PMC2835924
EDAT- 2010/03/12 06:00
MHDA- 2010/06/18 06:00
CRDT- 2010/03/12 06:00
PHST- 2009/05/20 00:00 [received]
PHST- 2009/08/27 00:00 [accepted]
PHST- 2010/03/12 06:00 [entrez]
PHST- 2010/03/12 06:00 [pubmed]
PHST- 2010/06/18 06:00 [medline]
AID - 10.3238/arztebl.2010.0105 [doi]
PST - ppublish
SO  - Dtsch Arztebl Int. 2010 Feb;107(7):105-13. doi: 10.3238/arztebl.2010.0105. Epub
      2010 Feb 19.


PMID- 20220683
OWN - NLM
STAT- MEDLINE
DCOM- 20100409
LR  - 20100311
IS  - 1357-6321 (Print)
IS  - 1357-6321 (Linking)
VI  - 16
IP  - 2
DP  - 2010 Feb
TI  - Conducting qualitative research with palliative care patients: applying Hammick's
      research ethics wheel.
PG  - 58, 60-2, 64-6, 68
AB  - This paper discusses the particular ethical issues that are present when
      attempting to undertake research involving patients accessing palliative care for
      cancer. It focuses on the use of Hammick's research ethics wheel (REW) in
      relation to a research study undertaken by the authors. Applying the REW enabled 
      the authors to identify and incorporate the ethical issues and dilemmas inherent 
      within such a study at a practical level. Ethical reasons for undertaking
      research with such vulnerable participants are explained and justified with
      reference to the REW. Ethical considerations are crucial to any research study
      involving human participants, but particularly so when dealing with participants 
      who are as vulnerable as those in a palliative care setting. The use of the REW
      enabled the authors to feel confident that all such concerns had been identified 
      before data collection began.
FAU - Whiting, Lisa S
AU  - Whiting LS
AD  - University of Hertfordshire, Hatfield, Hertfordshire, UK.
FAU - Vickers, Peter S
AU  - Vickers PS
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Int J Palliat Nurs
JT  - International journal of palliative nursing
JID - 9506762
MH  - Codes of Ethics
MH  - Confidentiality/ethics
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Informed Consent/ethics
MH  - *Models, Nursing
MH  - Neoplasms/psychology
MH  - Nurse's Role
MH  - Nursing Methodology Research/*ethics/organization & administration
MH  - *Palliative Care/psychology
MH  - Patient Rights/ethics
MH  - Principle-Based Ethics
MH  - *Qualitative Research
MH  - Research Personnel/ethics
MH  - *Vulnerable Populations
RF  - 40
EDAT- 2010/03/12 06:00
MHDA- 2010/04/10 06:00
CRDT- 2010/03/12 06:00
PHST- 2010/03/12 06:00 [entrez]
PHST- 2010/03/12 06:00 [pubmed]
PHST- 2010/04/10 06:00 [medline]
AID - 10.12968/ijpn.2010.16.2.46751 [doi]
PST - ppublish
SO  - Int J Palliat Nurs. 2010 Feb;16(2):58, 60-2, 64-6, 68. doi:
      10.12968/ijpn.2010.16.2.46751.


PMID- 20220627
OWN - NLM
STAT- MEDLINE
DCOM- 20100521
LR  - 20191210
IS  - 1462-4753 (Print)
IS  - 1462-4753 (Linking)
VI  - 15
IP  - 3
DP  - 2010 Mar
TI  - Focus on negative pressure: exploring the barriers to adoption.
PG  - 121-4
AB  - Recent government documents have identified the move from hospital-based care
      into the community and have suggested that more complex wound care can now be
      provided in the community setting with therapies such as negative pressure wound 
      therapy (NPWT). This focus group interview explores community tissue viability
      specialists' experiences and attitudes towards the use of NPWT in community
      settings. The study was conducted in compliance with relevant ethical guidelines.
      Data analysis identified various themes but this paper concentrates on three;
      untimely referrals; cost implications and mutual benefit and understanding.
FAU - Ousey, Karen
AU  - Ousey K
AD  - Department of Nursing and Health Studies, Centre for Health & Social Care
      Research, University of Huddersfield. K.J.Ousey@hud.ac.uk
FAU - Milne, Jeanette
AU  - Milne J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Community Nurs
JT  - British journal of community nursing
JID - 9815827
MH  - *Attitude of Health Personnel
MH  - Community Health Nursing/*organization & administration
MH  - Continuity of Patient Care
MH  - Cost-Benefit Analysis
MH  - *Diffusion of Innovation
MH  - Female
MH  - Focus Groups
MH  - Home Care Services/organization & administration
MH  - Humans
MH  - Male
MH  - Negative-Pressure Wound Therapy/economics/*nursing
MH  - *Nurse Clinicians/organization & administration/psychology
MH  - Nursing Assessment
MH  - Nursing Methodology Research
MH  - Outcome Assessment, Health Care
MH  - Patient Selection
MH  - Qualitative Research
MH  - Referral and Consultation/organization & administration
MH  - Skin Care/methods/nursing
MH  - United Kingdom
MH  - Wounds and Injuries/*therapy
EDAT- 2010/03/12 06:00
MHDA- 2010/05/22 06:00
CRDT- 2010/03/12 06:00
PHST- 2010/03/12 06:00 [entrez]
PHST- 2010/03/12 06:00 [pubmed]
PHST- 2010/05/22 06:00 [medline]
AID - 10.12968/bjcn.2010.15.3.46899 [doi]
PST - ppublish
SO  - Br J Community Nurs. 2010 Mar;15(3):121-4. doi: 10.12968/bjcn.2010.15.3.46899.


PMID- 20220290
OWN - NLM
STAT- MEDLINE
DCOM- 20100812
LR  - 20100311
IS  - 2005-3673 (Print)
IS  - 2005-3673 (Linking)
VI  - 40
IP  - 1
DP  - 2010 Feb
TI  - [Analysis of research papers published in the Journal of the Korean Academy of
      Nursing-focused on research trends, intervention studies, and level of evidence
      in the research].
PG  - 139-49
LID - 10.4040/jkan.2010.40.1.139 [doi]
AB  - PURPOSE: This study aimed was done to analyze recent trends in nursing research
      published in the Journal of Korean Academy of Nursing by focusing on the content 
      of nursing interventions and their level of evidence. METHODS: A total of 209
      studies published between 2007 and 2008 were reviewed using analysis criteria
      developed by the researchers. RESULTS: The number of quantitative studies was
      greater than that of qualitative studies. There was a slight increase in the
      number of qualitative studies and studies including elderly populations, which
      reflects the recent population trend in Korea. More randomized controlled trials 
      with a low risk of bias were needed to support more evidence-based nursing
      practice. Concerning the low rate of ethical consideration, stricter application 
      of research ethics needs to be encouraged. CONCLUSION: The findings of this study
      suggest the recent trends in nursing research and the direction of nursing
      research and review in the Journal.
FAU - Shin, Hyun Sook
AU  - Shin HS
AD  - College of Nursing Science, East-West Nursing Research Institute, Kyung Hee
      University, Seoul, Korea.
FAU - Hyun, Myung Sun
AU  - Hyun MS
FAU - Ku, Mi Ok
AU  - Ku MO
FAU - Cho, Myung Ok
AU  - Cho MO
FAU - Kim, Sook Young
AU  - Kim SY
FAU - Jeong, Jea Sim
AU  - Jeong JS
FAU - Jeong, Geum Hee
AU  - Jeong GH
FAU - Seomoon, Gyeong Ae
AU  - Seomoon GA
FAU - Son, Youn Jung
AU  - Son YJ
LA  - kor
PT  - English Abstract
PT  - Journal Article
PL  - Korea (South)
TA  - J Korean Acad Nurs
JT  - Journal of Korean Academy of Nursing
JID - 101488689
SB  - IM
MH  - Bibliometrics
MH  - Humans
MH  - Nursing Research/*trends
MH  - *Periodicals as Topic
MH  - Qualitative Research
MH  - Republic of Korea
EDAT- 2010/03/12 06:00
MHDA- 2010/08/13 06:00
CRDT- 2010/03/12 06:00
PHST- 2010/03/12 06:00 [entrez]
PHST- 2010/03/12 06:00 [pubmed]
PHST- 2010/08/13 06:00 [medline]
AID - 201002139 [pii]
AID - 10.4040/jkan.2010.40.1.139 [doi]
PST - ppublish
SO  - J Korean Acad Nurs. 2010 Feb;40(1):139-49. doi: 10.4040/jkan.2010.40.1.139.


PMID- 20220151
OWN - NLM
STAT- MEDLINE
DCOM- 20101020
LR  - 20100615
IS  - 1049-7323 (Print)
IS  - 1049-7323 (Linking)
VI  - 20
IP  - 7
DP  - 2010 Jul
TI  - Delusions and qualitative confusions: a dialogic collaborative exploration.
PG  - 1008-18
LID - 10.1177/1049732310363805 [doi]
AB  - In this article we describe the application of a dialogic collaborative process
      (DCP) to the exploration of issues arising from our own interview-based research 
      in populations prone to delusions. We used the DCP to investigate and develop a
      shared understanding of ethical and epistemological tensions and their potential 
      influence on the research process. Although our meaning making involved agreement
      to disagree in relation to specific issues, we are united in the view that full
      reporting and individual and team reflexivity are the hallmarks of quality for
      research with these populations. In a context in which qualitative research is
      increasingly conducted by multidisciplinary and hierarchical teams, we take the
      view that the DCP offers an effective and efficient means to construct
      evidence-based knowledge. However, we caution that to maximize benefits, the
      process must be underpinned by individual and collective active self-awareness
      and clarity about the commitment of each participant in the dialogue.
FAU - Patterson, Sue E
AU  - Patterson SE
AD  - Imperial College London, London, United Kingdom. sue.patterson@imperial.ac.uk
FAU - Hart, Jozella
AU  - Hart J
FAU - Weaver, Tim D
AU  - Weaver TD
LA  - eng
PT  - Journal Article
DEP - 20100310
PL  - United States
TA  - Qual Health Res
JT  - Qualitative health research
JID - 9202144
MH  - Adult
MH  - Confusion/*psychology
MH  - *Cooperative Behavior
MH  - Delusions/*psychology
MH  - Ethics, Research
MH  - Female
MH  - Humans
MH  - Interview, Psychological/methods
MH  - Male
MH  - Mental Health
MH  - Qualitative Research
EDAT- 2010/03/12 06:00
MHDA- 2010/10/21 06:00
CRDT- 2010/03/12 06:00
PHST- 2010/03/12 06:00 [entrez]
PHST- 2010/03/12 06:00 [pubmed]
PHST- 2010/10/21 06:00 [medline]
AID - 1049732310363805 [pii]
AID - 10.1177/1049732310363805 [doi]
PST - ppublish
SO  - Qual Health Res. 2010 Jul;20(7):1008-18. doi: 10.1177/1049732310363805. Epub 2010
      Mar 10.


PMID- 20219140
OWN - NLM
STAT- MEDLINE
DCOM- 20130204
LR  - 20181113
IS  - 1471-2458 (Electronic)
IS  - 1471-2458 (Linking)
VI  - 10
DP  - 2010 Mar 11
TI  - Canadian survey on pandemic flu preparations.
PG  - 125
LID - 10.1186/1471-2458-10-125 [doi]
AB  - BACKGROUND: The management of pandemic influenza creates public health
      challenges.An ethical framework, 'Stand on Guard for Thee: ethical considerations
      in pandemic influenza preparedness' that served as a template for the World
      Health Organization's global consultation on pandemic planning, was transformed
      into a survey administered to a random sample of 500 Canadians to obtain opinions
      on key ethical issues in pandemic preparedness planning. METHODS: All framework
      authors and additional investigators created items that were pilot-tested with
      volunteers of both sexes and all socioeconomic strata. Surveys were telephone
      administered with random sampling achieved via random digit dialing (RDD).
      Eligible participants were adults, 18 years or older, with per province
      stratification equaling provincial percent of national population. Descriptive
      results were tabulated and logistic regression analyses were used to assess
      whether demographic factors were significantly associated with outcomes. RESULTS:
      5464 calls identified 559 eligible participants of whom 88.5% completed surveys. 
      Over 90% of subjects agreed the most important goal of pandemic influenza
      preparations was saving lives, with 41% endorsing saving lives solely in Canada
      and 50% endorsing saving lives globally as the highest priority. Older age (OR = 
      8.51, p < 0.05) and current employment (OR = 9.48, p < 0.05) were associated with
      an endorsement of saving lives globally as highest priority. About 90% of
      respondents supported the obligation of health care workers to report to work and
      face influenza pandemic risks excepting those with a serious health condition
      that increased risks. Over 84% supported the government's provision of disability
      insurance and death benefits for health care workers facing elevated risk. Strong
      majorities favored stocking adequate protective antiviral dosages for all
      Canadians (92%) and, if effective, influenza vaccinations (95%). Over 70% agreed 
      Canada should provide international assistance to poorer countries for pandemic
      preparation, even if resources for Canadians were reduced. While 92% of this
      group, believed provision should be 7 to 10% of all resources generated, 43%
      believed the provision should be greater than 10%. CONCLUSIONS: Results suggest
      trust in public health officials to make difficult decisions, providing emphasis 
      on reciprocity and respect for individual rights.
FAU - Ritvo, Paul
AU  - Ritvo P
AD  - School of Kinesiology and Health Science, York University, Toronto, Canada.
      pritvo@yorku.ca
FAU - Wilson, Kumanan
AU  - Wilson K
FAU - Gibson, J L
AU  - Gibson JL
FAU - Guglietti, C
AU  - Guglietti C
FAU - Tracy, C S
AU  - Tracy CS
FAU - Nie, J X
AU  - Nie JX
FAU - Jadad, A R
AU  - Jadad AR
FAU - Upshur, R E G
AU  - Upshur RE
CN  - University of Toronto Joint Centre for Bioethics Pandemic Ethics Working Group
LA  - eng
PT  - Journal Article
DEP - 20100311
PL  - England
TA  - BMC Public Health
JT  - BMC public health
JID - 100968562
SB  - IM
MH  - Adult
MH  - Aged
MH  - Canada
MH  - Female
MH  - Health Care Surveys
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Influenza, Human/epidemiology/*prevention & control
MH  - Male
MH  - Middle Aged
MH  - Pandemics/*prevention & control
MH  - Patient Acceptance of Health Care/psychology
MH  - Preventive Health Services/standards
MH  - Quarantine
MH  - Resource Allocation
MH  - Surveys and Questionnaires
PMC - PMC2842233
IR  - Bensimon C
FIR - Bensimon, C
IR  - McDougall C
FIR - McDougall, C
IR  - Faith K
FIR - Faith, K
IR  - Kapiriri L
FIR - Kapiriri, L
IR  - Keelan J
FIR - Keelan, J
IR  - Perez D
FIR - Perez, D
IR  - Robertson A
FIR - Robertson, A
IR  - Rossiter K
FIR - Rossiter, K
IR  - Silva D
FIR - Silva, D
IR  - Smith M
FIR - Smith, M
EDAT- 2010/03/12 06:00
MHDA- 2013/02/05 06:00
CRDT- 2010/03/12 06:00
PHST- 2009/07/08 00:00 [received]
PHST- 2010/03/11 00:00 [accepted]
PHST- 2010/03/12 06:00 [entrez]
PHST- 2010/03/12 06:00 [pubmed]
PHST- 2013/02/05 06:00 [medline]
AID - 1471-2458-10-125 [pii]
AID - 10.1186/1471-2458-10-125 [doi]
PST - epublish
SO  - BMC Public Health. 2010 Mar 11;10:125. doi: 10.1186/1471-2458-10-125.


PMID- 20219111
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20100520
LR  - 20200930
IS  - 1753-2000 (Electronic)
IS  - 1753-2000 (Linking)
VI  - 4
DP  - 2010 Mar 10
TI  - Controversies concerning the diagnosis and treatment of bipolar disorder in
      children.
PG  - 9
LID - 10.1186/1753-2000-4-9 [doi]
AB  - This commentary grows out of an interdisciplinary workshop focused on
      controversies surrounding the diagnosis and treatment of bipolar disorder (BP) in
      children. Although debate about the occurrence and frequency of BP in children is
      more than 50 years old, it increased in the mid 1990s when researchers adapted
      the DSM account of bipolar symptoms to diagnose children. We offer a brief
      history of the debate from the mid 90s through the present, ending with current
      efforts to distinguish between a small number of children whose behaviors closely
      fit DSM criteria for BP, and a significantly larger number of children who have
      been receiving a BP diagnosis but whose behaviors do not closely fit those
      criteria. We agree with one emerging approach, which gives part or all of that
      larger number of children a new diagnosis called Severe Mood Dysregulation or
      Temper Dysregulation Disorder with Dysphoria.Three major concerns arose about
      interpreting the DSM criteria more loosely in children than in adults. If
      clinicians offer a treatment for disorder A, but the patient has disorder B,
      treatment may be compromised. Because DSM's diagnostic labels are meant to
      facilitate research, when they are applied inconsistently, such research is
      compromised. And because BP has a strong genetic component, the label can
      distract attention from the family or social context.Once a BP diagnosis is made,
      concerns remain regarding the primary, pharmacological mode of treatment: data
      supporting the efficacy of the often complex regimens are weak and side effects
      can be significant. However, more than is widely appreciated, data do support the
      efficacy of the psychosocial treatments that should accompany pharmacotherapy.
      Physicians, educators, and families should adopt a multimodal approach, which
      focuses as much on the child's context as on her body. If physicians are to
      fulfill their ethical obligation to facilitate truly informed consent, they must 
      be forthcoming with families about the relevant uncertainties and complexities.
FAU - Parens, Erik
AU  - Parens E
AD  - The Hastings Center, Garrison, NY 10524, USA. parense@thehastingscenter.org
FAU - Johnston, Josephine
AU  - Johnston J
LA  - eng
PT  - Journal Article
DEP - 20100310
PL  - England
TA  - Child Adolesc Psychiatry Ment Health
JT  - Child and adolescent psychiatry and mental health
JID - 101297974
PMC - PMC2846895
EDAT- 2010/03/12 06:00
MHDA- 2010/03/12 06:01
CRDT- 2010/03/12 06:00
PHST- 2009/10/08 00:00 [received]
PHST- 2010/03/10 00:00 [accepted]
PHST- 2010/03/12 06:00 [entrez]
PHST- 2010/03/12 06:00 [pubmed]
PHST- 2010/03/12 06:01 [medline]
AID - 1753-2000-4-9 [pii]
AID - 10.1186/1753-2000-4-9 [doi]
PST - epublish
SO  - Child Adolesc Psychiatry Ment Health. 2010 Mar 10;4:9. doi:
      10.1186/1753-2000-4-9.


PMID- 20218998
OWN - NLM
STAT- MEDLINE
DCOM- 20100713
LR  - 20171116
IS  - 1479-828X (Electronic)
IS  - 0004-8666 (Linking)
VI  - 50
IP  - 1
DP  - 2010 Feb
TI  - Informing policy for the Australian context - Costs, outcomes and cost savings of
      prenatal carrier screening for cystic fibrosis.
PG  - 51-9
LID - 10.1111/j.1479-828X.2009.01111.x [doi]
AB  - AIMS: To examine the costs, outcomes and cost savings of three models of prenatal
      cystic fibrosis (CF) carrier screening compared to no screening from a public
      health sector perspective. METHODS: A decision tree was generated to estimate
      costs and outcomes for each screening model for a hypothetical cohort of 38 000
      pregnancies. Sensitivity analysis assessed the impact of model parameter
      variation. RESULTS: Under baseline assumptions, the initial annual cost to
      provide a prenatal CF carrier-screening programme is Au$5.32 million, Au$3.35
      million and $2.93 million for one-step, two-step simultaneous and two-step
      sequential screening respectively. Annual costs are significantly lower for an
      established programme. No screening model provides a net saving over a lifetime
      horizon; however, the results were sensitive to variation in lifetime cost of
      care, screening test costs and number of pregnancies per carrier couple.
      CONCLUSIONS: Under some scenarios, prenatal CF carrier screening is cost saving
      to the health system; however, this is not conclusive and depends on several
      factors. Cost remains a potential barrier due to the substantial level of funding
      required in the short term. Feasibility and psychosocial, ethical and legal
      implications of screening need to be considered. Additionally, consultation is
      required with the Australian community on the acceptability and/or desire for
      prenatal CF carrier screening.
FAU - Maxwell, Susannah
AU  - Maxwell S
AD  - Department of Health, Perth, WA, Australia.
FAU - Brameld, Kate
AU  - Brameld K
FAU - Youngs, Leanne
AU  - Youngs L
FAU - Geelhoed, Elizabeth
AU  - Geelhoed E
FAU - O'Leary, Peter
AU  - O'Leary P
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Aust N Z J Obstet Gynaecol
JT  - The Australian & New Zealand journal of obstetrics & gynaecology
JID - 0001027
SB  - IM
MH  - Australia
MH  - Cost-Benefit Analysis
MH  - Cystic Fibrosis/*economics/genetics
MH  - Decision Trees
MH  - Female
MH  - *Genetic Carrier Screening
MH  - *Health Care Costs
MH  - Health Policy/*economics
MH  - Humans
MH  - Pregnancy
MH  - Prenatal Diagnosis/*economics
EDAT- 2010/03/12 06:00
MHDA- 2010/07/14 06:00
CRDT- 2010/03/12 06:00
PHST- 2010/03/12 06:00 [entrez]
PHST- 2010/03/12 06:00 [pubmed]
PHST- 2010/07/14 06:00 [medline]
AID - AJO1111 [pii]
AID - 10.1111/j.1479-828X.2009.01111.x [doi]
PST - ppublish
SO  - Aust N Z J Obstet Gynaecol. 2010 Feb;50(1):51-9. doi:
      10.1111/j.1479-828X.2009.01111.x.


PMID- 20218920
OWN - NLM
STAT- MEDLINE
DCOM- 20100726
LR  - 20191220
IS  - 1744-7682 (Electronic)
IS  - 1471-2598 (Linking)
VI  - 10
IP  - 4
DP  - 2010 Apr
TI  - Potential therapeutic applications of muscle-derived mesenchymal stem and
      progenitor cells.
PG  - 505-17
LID - 10.1517/14712591003610606 [doi]
AB  - IMPORTANCE OF THE FIELD: Mesenchymal adult stem cells have properties that make
      them attractive for use in tissue engineering and regenerative medicine. They are
      inherently plastic, enabling them to differentiate along different lineages, and 
      promote wound healing and regeneration of surrounding tissues by modulating
      immune and inflammatory responses, promoting angiogenesis and secreting other
      trophic factors. Unlike embryonic stem cells, clinical uses of mesenchymal stem
      cells are not encumbered by ethical considerations or legal restrictions. AREAS
      COVERED IN THIS REVIEW: We discuss skeletal muscle as a source of mesenchymal
      stem and progenitor cells by reviewing their biology and current applications in 
      tissue engineering and regenerative medicine. This paper covers literature from
      the last 5 - 10 years. WHAT THE READER WILL GAIN: Skeletal muscle is a plentiful 
      source of mesenchymal stem and progenitor cells. This tissue may be obtained via 
      routine biopsy or collection after surgical debridement. We describe the biology 
      of these cells and provide an overview of therapeutic applications currently
      being developed to take advantage of their regenerative properties. TAKE HOME
      MESSAGE: There is potential for stem and progenitor cells derived from skeletal
      muscle to be incorporated in clinical interventions, either as a cellular therapy
      to modify the natural history of disease or as a component of engineered tissue
      constructs that can replace diseased or damaged tissues.
FAU - Jackson, Wesley M
AU  - Jackson WM
AD  - University of Pittsburgh School of Medicine, Center for Cellular and Molecular
      Engineering, Department of Orthopaedic Surgery, 450 Technology Drive, Room 221,
      Pittsburgh, PA 15232, USA.
FAU - Nesti, Leon J
AU  - Nesti LJ
FAU - Tuan, Rocky S
AU  - Tuan RS
LA  - eng
GR  - F30 AA005516-01/AA/NIAAA NIH HHS/United States
GR  - F30 AA005516-02/AA/NIAAA NIH HHS/United States
GR  - F30 AA005516-03/AA/NIAAA NIH HHS/United States
GR  - Z01 AR041131/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Expert Opin Biol Ther
JT  - Expert opinion on biological therapy
JID - 101125414
SB  - IM
MH  - Adult
MH  - Humans
MH  - Mesenchymal Stem Cells/*cytology
MH  - Muscle, Skeletal/*cytology
MH  - Regeneration
RF  - 117
PMC - PMC3018682
MID - NIHMS251379
EDAT- 2010/03/12 06:00
MHDA- 2010/07/27 06:00
CRDT- 2010/03/12 06:00
PHST- 2010/03/12 06:00 [entrez]
PHST- 2010/03/12 06:00 [pubmed]
PHST- 2010/07/27 06:00 [medline]
AID - 10.1517/14712591003610606 [doi]
PST - ppublish
SO  - Expert Opin Biol Ther. 2010 Apr;10(4):505-17. doi: 10.1517/14712591003610606.


PMID- 20218827
OWN - NLM
STAT- MEDLINE
DCOM- 20110113
LR  - 20220409
IS  - 1466-187X (Electronic)
IS  - 0142-159X (Linking)
VI  - 32
IP  - 3
DP  - 2010
TI  - Psychological well-being of interns in Hong Kong: what causes them stress and
      what helps them.
PG  - e120-6
LID - 10.3109/01421590903449894 [doi]
AB  - BACKGROUND: Many doctors experience psychological ill health. Interns are known
      to be particularly vulnerable. AIM: To examine the level of depression, anxiety
      and stress in interns in Hong Kong, as well as the causes and how they cope.
      METHODS: A questionnaire was designed based on the themes identified in three
      focus groups of medical graduates of Year 2004 of the University of Hong Kong.
      The 21-item Depression, Anxiety and Stress Scale (DASS 21) was also administered.
      All 155 graduates of the same year were invited to participate with a response
      rate of 63%. RESULTS: Percentages of respondents with abnormal levels of
      depression, anxiety and stress were 35.8%, 35.4% and 29.2%, respectively.
      Frequent calls during night shift, long working hours and heavy workload
      constituted the most significant stressors. Factor analysis of the stressors
      showed that seven factors could explain 68% of the total variance:
      multidisciplinary team working issues, clinical difficulties, job seeking and
      employment, workload issues, ethical and interpersonal issues, adjustment to job 
      rotation and performance appraisal. Holidays, peers and sleep offered the most
      significant relief. CONCLUSION: Interns experience considerable depression,
      anxiety and stress. The source of stress is multi-faceted, but workload is the
      most significant stressor. Peer support groups may relief stress.
FAU - Lam, T P
AU  - Lam TP
AD  - Family Medicine Unit, Department of Medicine, The University of Hong Kong, Hong
      Kong, PR China. tplam@hku.hk
FAU - Wong, J G W S
AU  - Wong JG
FAU - Ip, Mary S M
AU  - Ip MS
FAU - Lam, K F
AU  - Lam KF
FAU - Pang, S L
AU  - Pang SL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Med Teach
JT  - Medical teacher
JID - 7909593
SB  - IM
MH  - *Adaptation, Psychological
MH  - Adult
MH  - Anxiety/*epidemiology/etiology
MH  - Data Collection
MH  - Depression/*epidemiology/etiology
MH  - Female
MH  - Focus Groups
MH  - Hong Kong/epidemiology
MH  - Humans
MH  - Internship and Residency/*statistics & numerical data
MH  - Male
MH  - Psychometrics
MH  - Qualitative Research
MH  - Stress, Psychological/*complications
MH  - Surveys and Questionnaires
MH  - Work Schedule Tolerance
MH  - Workload
MH  - Young Adult
EDAT- 2010/03/12 06:00
MHDA- 2011/01/14 06:00
CRDT- 2010/03/12 06:00
PHST- 2010/03/12 06:00 [entrez]
PHST- 2010/03/12 06:00 [pubmed]
PHST- 2011/01/14 06:00 [medline]
AID - 10.3109/01421590903449894 [doi]
PST - ppublish
SO  - Med Teach. 2010;32(3):e120-6. doi: 10.3109/01421590903449894.


PMID- 20218746
OWN - NLM
STAT- MEDLINE
DCOM- 20100604
LR  - 20181113
IS  - 1179-2019 (Electronic)
IS  - 1174-5878 (Linking)
VI  - 12
IP  - 2
DP  - 2010 Apr 1
TI  - Published pediatric randomized drug trials in developing countries, 1996-2002.
PG  - 99-103
LID - 10.2165/11316260-000000000-00000 [doi]
AB  - BACKGROUND: The greatest burden of disease in children lies in the developing
      world; however, previous reviews have suggested that few randomized controlled
      trials (RCTs) involving children take place in developing countries. Children in 
      developing countries deserve the same standard of medicines as those in developed
      countries, i.e. appropriate medications for the specific diseases that occur.
      OBJECTIVE: To elucidate published pediatric therapeutic RCTs that have taken
      place in the developing world and to determine whether they are appropriate for
      the major diseases occurring there, and to explore their approach to safety
      monitoring. METHODS: A previously assembled database of pediatric RCTs published 
      between 1996 and 2002, from journals indexed in MEDLINE, was analyzed. The main
      country of setting of the RCTs was categorized as having low, medium or high
      development status according to the Human Development Index (HDI). Articles were 
      read to add the WHO International Classification of Diseases 10th Revision
      (ICD-10) category of the disease studied, the WHO Collaborating Centre for Drug
      Statistics Methodology Anatomical Therapeutic Chemical (ATC) classification
      system category of the main drug therapy studied, the source of funding, and
      ethical approval to the variables already recorded in the database. RESULTS: One 
      hundred and fifty-eight (22%) of the 733 RCTs analyzed took place in medium and
      low HDI (developing) countries. The disease areas studied seemed appropriate,
      with 89 (56%) of the 158 RCTs studying infectious and parasitic diseases.
      Ninety-nine (63%) RCTs from developing countries were trials of antiparasitic and
      anti-infective drugs. Compared with studies from high HDI countries, a
      significantly lower proportion of articles from medium and low HDI countries
      mentioned ethical committee or institutional review board approval, and safety
      monitoring. Only one paper from low and medium HDI countries mentioned the
      presence of a safety monitoring committee/data safety monitoring board.
      CONCLUSIONS: Published pediatric drug RCTs conducted in developing countries
      appear to study appropriate diseases but the results show that fewer RCTs are
      undertaken compared with the developed world. The standard of reporting for RCTs 
      from developing countries needs attention to ensure that adequate information can
      be obtained, especially with regard to safety monitoring.
FAU - Nor Aripin, Khairun N B
AU  - Nor Aripin KN
AD  - Academic Division of Child Health, University of Nottingham, Derbyshire
      Children's Hospital, Derby DE22 3DT, UK. mgxknbn@nottingham.ac.uk
FAU - Sammons, Helen M
AU  - Sammons HM
FAU - Choonara, Imti
AU  - Choonara I
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Paediatr Drugs
JT  - Paediatric drugs
JID - 100883685
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Child
MH  - Clinical Trials Data Monitoring Committees/*organization & administration
MH  - Developing Countries
MH  - *Drug-Related Side Effects and Adverse Reactions
MH  - Human Development
MH  - Humans
MH  - International Classification of Diseases
MH  - MEDLINE
MH  - Pharmaceutical Preparations/administration & dosage
MH  - Randomized Controlled Trials as Topic/*statistics & numerical data
MH  - World Health Organization
EDAT- 2010/03/12 06:00
MHDA- 2010/06/05 06:00
CRDT- 2010/03/12 06:00
PHST- 2010/03/12 06:00 [entrez]
PHST- 2010/03/12 06:00 [pubmed]
PHST- 2010/06/05 06:00 [medline]
AID - 3 [pii]
AID - 10.2165/11316260-000000000-00000 [doi]
PST - ppublish
SO  - Paediatr Drugs. 2010 Apr 1;12(2):99-103. doi: 10.2165/11316260-000000000-00000.


PMID- 20218677
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20100916
LR  - 20100615
IS  - 1520-4898 (Electronic)
IS  - 0001-4842 (Linking)
VI  - 43
IP  - 6
DP  - 2010 Jun 15
TI  - The coordinated use of synchrotron spectroelectrochemistry for corrosion studies 
      on heritage metals.
PG  - 927-35
LID - 10.1021/ar900269f [doi]
AB  - Corrosion is a major source of degradation in heritage metal objects, and any
      remedial measures are subject to a strong (Western) ethic that favors
      conservation as opposed to restoration. Accordingly, major scientific challenges 
      exist for developing appropriate treatment methods to stabilize and protect
      artifacts after they are recovered from an archaeological site, both before and
      during their display or storage in a museum. Because inappropriate treatments can
      cause irreversible damage to irreplaceable objects, it is crucial that the
      chemical processes involved are fully understood and characterized before any
      preservation work is undertaken. In this regard, large infrastructural facilities
      such as synchrotrons, neutron sources, and particle accelerators provide a wealth
      of analytical possibilities, unavailable in smaller scale laboratories. In
      general, the intensity of the radiation available allows measurements on a short 
      time scale or with high spatial resolution (or both), so heterogeneous changes
      induced by a chemical process can be recorded while they occur. The penetrative
      nature of the radiation (e.g., X-rays, protons, or neutrons) also allows a sample
      to be studied in air. If necessary, complete artifacts (such as paintings or
      statuettes) can be examined. In situ analysis in a controlled environment, such
      as a liquid or corrosive atmosphere, also becomes an exciting possibility.
      Finally, there are many complementary techniques (local atomic structure or
      crystal structure determination, macroscopic 3-D imaging (tomographies), imaging 
      chemical analysis, and so on) so the many distinct details of a problem can be
      thoroughly explored. In this Account, we discuss the application of this general 
      philosophy to studies of corrosion and its prevention in cultural heritage
      metals, focusing on our recent work on copper alloys. More specifically, we use
      synchrotron-based techniques to evaluate the use of corrosion potential
      measurements as a possible monitoring method for copper-based objects recovered
      from marine environments. The extraction of chlorides from such artifacts is a
      process that must take place before the artifacts are put on display or stored,
      because air exposure of untreated metal will result in severe damage or loss in
      as little as a few weeks. Chloride is removed by soaking the artifact for up to
      two years in tap water or dilute sodium sesquicarbonate, with regular solution
      changes. Our research supports the effectiveness of this treatment for thin
      nantokite (copper(I) chloride) layers, but it raises questions for copper
      hydroxychlorides (atacamite and paratacamite), especially when these minerals are
      trapped in fissures. Electrochemical parameters such as the corrosion potential
      are shown to be insensitive to the physical presence of large hydroxychloride
      coverages if they overlie a cuprite (Cu(2)O) layer. X-ray absorption spectroscopy
      proves to be a good monitor for the chloride in solution over the working
      electrode, whereas X-ray diffraction offers the potential for real-time
      measurement of the surface chloride composition. In principle, the two techniques
      together offer the possibility of monitoring surface and fluid levels
      simultaneously.
FAU - Adriaens, Annemie
AU  - Adriaens A
AD  - Department of Analytical Chemistry, Ghent University, Krijgslaan 281-S12, B-9000 
      Ghent, Belgium. annemie.adriaens@ugent.be
FAU - Dowsett, Mark
AU  - Dowsett M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Acc Chem Res
JT  - Accounts of chemical research
JID - 0157313
EDAT- 2010/03/12 06:00
MHDA- 2010/03/12 06:01
CRDT- 2010/03/12 06:00
PHST- 2010/03/12 06:00 [entrez]
PHST- 2010/03/12 06:00 [pubmed]
PHST- 2010/03/12 06:01 [medline]
AID - 10.1021/ar900269f [doi]
PST - ppublish
SO  - Acc Chem Res. 2010 Jun 15;43(6):927-35. doi: 10.1021/ar900269f.


PMID- 20217965
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110613
LR  - 20190225
IS  - 1735-3947 (Electronic)
IS  - 1029-2977 (Linking)
VI  - 13
IP  - 2
DP  - 2010 Mar
TI  - Retraction.
PG  - 174
AB  - We are sorry that we have to retract the following articles due to significant
      plagiarism by authors. Archives of Iranian Medicine is a member of Committee on
      Publication Ethics (COPE) and is devoted to its guidelines and principles. Hereby
      we apologize for the inconvenience to the readers. --Ameloblastomatous calcifying
      odontogenic cyst: a case report of a rare histologic variant. Arch Iran Med. 2009
      Jul;12(4):417-20. --Peripheral calcifying odontogenic cyst. Arch Iran Med. 2009
      May;12(3):309-12. --Desmoplastic ameloblastoma (a hybrid variant): report of a
      case and review of the literature. Arch Iran Med. 2009 May;12(3):304-8.
      --Squamous cell carcinoma of the tongue in a 13-year-old boy. Arch Iran Med. 2008
      May;11(3):341-3.
LA  - eng
PT  - Retraction of Publication
PL  - Iran
TA  - Arch Iran Med
JT  - Archives of Iranian medicine
JID - 100889644
ROF - Seyedmajidi M, Faizabadi M. Arch Iran Med. 2008 May;11(3):341-3. PMID: 18426330
ROF - Yazdi I, Seyedmajidi M, Foroughi R. Arch Iran Med. 2009 May;12(3):304-8. PMID:
      19400611
ROF - Seyedmajidi M, Feizabadi M. Arch Iran Med. 2009 May;12(3):309-12. PMID: 19400612
ROF - Nosrati K, Seyedmajidi M. Arch Iran Med. 2009 Jul;12(4):417-20. PMID: 19566363
EDAT- 2010/03/12 06:00
MHDA- 2011/06/15 06:00
CRDT- 2010/03/12 06:00
PHST- 2010/03/12 06:00 [entrez]
PHST- 2010/03/12 06:00 [pubmed]
PHST- 2011/06/15 06:00 [medline]
PST - ppublish
SO  - Arch Iran Med. 2010 Mar;13(2):174.


PMID- 20217379
OWN - NLM
STAT- MEDLINE
DCOM- 20100514
LR  - 20161109
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 669
DP  - 2010
TI  - Patterns of brain activity in response to respiratory stimulation in patients
      with idiopathic hyperventilation (IHV).
PG  - 341-5
LID - 10.1007/978-1-4419-5692-7_70 [doi]
AB  - Dyspnoea, usually defined as an uncomfortable awareness of breathing, is one of
      the most frequent and distressing symptoms experienced by patients with lung
      disease. Idiopathic hyperventilation (IHV) has unknown aetiology and little is
      known about the mechanisms that cause the characteristic sustained hypocapnia and
      chronic dyspnoea. We have shown in IHV and other chronic respiratory disorders
      that air hunger is the dominant sensation during exercise, while resting
      breathlessness is characterised by an affective component. The increased drive to
      breathe in IHV, and indeed dyspnoea in all chronic respiratory disorders, might
      be better understood if the central mechanisms of dyspnoea were known. The aim of
      the present study was to characterise the cortical processing of
      respiratory-related sensory inputs in patients with IHV. Four patients with IHV
      were studied with ethical approval. Respiratory stimulation was produced using
      transient occlusion of inspiration (TIO) during spontaneous breathing (delivered 
      in early inspiration with duration c. 300 ms; this is well tolerated) while BOLD 
      fMRI was performed on a 3 Tesla Siemens Trio. TIO was associated with significant
      activation in sensorimotor and pre-motor cortical areas and the cerebellum,
      notably the anterior insula, an area previously associated with breathlessness in
      healthy volunteers. These preliminary observations on the pattern of brain
      activity in response to respiratory stimulation support the hypothesis that
      breathlessness in IHV may reflect inappropriate cortical processing of
      respiratory-related sensory inputs.
FAU - Jack, S
AU  - Jack S
AD  - Unit of Inflammation Research, University Hospital Aintree, Liverpool, England.
      s.jack@liverpool.ac.uk
FAU - Kemp, G J
AU  - Kemp GJ
FAU - Bimson, W E
AU  - Bimson WE
FAU - Calverley, P M A
AU  - Calverley PM
FAU - Corfield, D R
AU  - Corfield DR
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
SB  - IM
MH  - Brain/*physiology
MH  - Humans
MH  - Hyperventilation/*physiopathology
MH  - Inhalation/physiology
MH  - Magnetic Resonance Imaging
MH  - *Respiration
EDAT- 2010/03/11 06:00
MHDA- 2010/05/15 06:00
CRDT- 2010/03/11 06:00
PHST- 2010/03/11 06:00 [entrez]
PHST- 2010/03/11 06:00 [pubmed]
PHST- 2010/05/15 06:00 [medline]
AID - 10.1007/978-1-4419-5692-7_70 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2010;669:341-5. doi: 10.1007/978-1-4419-5692-7_70.


PMID- 20217196
OWN - NLM
STAT- MEDLINE
DCOM- 20110218
LR  - 20181113
IS  - 1573-3602 (Electronic)
IS  - 1050-5350 (Linking)
VI  - 26
IP  - 4
DP  - 2010 Dec
TI  - An animal model of slot machine gambling: the effect of structural
      characteristics on response latency and persistence.
PG  - 521-31
LID - 10.1007/s10899-010-9183-3 [doi]
AB  - Despite the prevalence of problem gamblers and the ethical issues involved in
      studying gambling behavior with humans, few animal models of gambling have been
      developed. When designing an animal model it is necessary to determine if
      behavior in the paradigm is similar to human gambling. In human studies, response
      latencies following winning trials and near win trials are greater than those
      following clear losses. Weatherly and Derenne (Anal Gambl Behav 1:79-89, 2007)
      investigated whether this pattern was found with rats working in an animal
      analogue of slot machine gambling. They found a similar pattern of response
      latencies but the subjects' behavior did not come under control of the visual
      stimuli signalling the different outcomes. The animal model of slot machine
      gambling we used addressed procedural issues in Weatherly and Derenne's model and
      examined whether reinforcer magnitude and the presence of near win trials
      influenced response latency and resistance to extinction. Response latencies of
      the six female Norway Hooded rats varied as a function of reinforcer magnitude
      and the presence of near-win trials. These results are consistent with prior
      research and with the idea that near win trials serve as conditional reinforcers.
FAU - Peters, Heather
AU  - Peters H
AD  - School of Information and Social Sciences, Open Polytechnic, Private Bag 31914,
      Lower Hutt, 5040, New Zealand. Heather.Peters@openpolytechnic.ac.nz
FAU - Hunt, Maree
AU  - Hunt M
FAU - Harper, David
AU  - Harper D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Gambl Stud
JT  - Journal of gambling studies
JID - 9425991
SB  - IM
MH  - Animal Experimentation
MH  - Animals
MH  - *Behavior, Animal
MH  - Female
MH  - Gambling/*physiopathology/*psychology
MH  - Impulsive Behavior/*physiopathology/*psychology
MH  - *Models, Animal
MH  - Random Allocation
MH  - Rats
MH  - Reaction Time
MH  - *Reward
EDAT- 2010/03/11 06:00
MHDA- 2011/02/22 06:00
CRDT- 2010/03/11 06:00
PHST- 2010/03/11 06:00 [entrez]
PHST- 2010/03/11 06:00 [pubmed]
PHST- 2011/02/22 06:00 [medline]
AID - 10.1007/s10899-010-9183-3 [doi]
PST - ppublish
SO  - J Gambl Stud. 2010 Dec;26(4):521-31. doi: 10.1007/s10899-010-9183-3.


PMID- 20216431
OWN - NLM
STAT- MEDLINE
DCOM- 20100803
LR  - 20110314
IS  - 1539-2031 (Electronic)
IS  - 0192-0790 (Linking)
VI  - 44
IP  - 5
DP  - 2010 May-Jun
TI  - Male gender and renal dysfunction are predictors of adverse outcome in
      nonpostoperative ischemic colitis patients.
PG  - e96-100
LID - 10.1097/MCG.0b013e3181d347b9 [doi]
AB  - OBJECTIVE: Ischemic colitis (IC) spans a broad spectrum from self-limiting
      illness to intestinal gangrene and mortality. Prognostic factors specifically for
      nonpostoperative IC were not fully characterized. We aim to focus on
      nonpostoperative IC in patients with renal dysfunction and try to identify
      prognostic factors for adverse outcomes. METHODS: We conducted a retrospective
      analysis at a university-affiliated tertiary medical center in Taiwan. From
      January 2003 to August 2008, 25 men and 52 women (mean age: 66 y) had
      colonoscopic biopsy-proven IC without prior culprit surgery. We estimated
      glomerular filtration rate with simplified Modification of Diet in Renal Disease 
      equation. Nine patients with glomerular filtration rate below 30 mL per minute
      per 1.73 m were classified as renal dysfunction group (including 7 dialysis
      patients). Adverse outcomes were defined as need for surgery and mortality.
      Predictors for adverse outcomes were captured by univariate and multivariate
      analysis. Research ethical committee approved the study protocol. RESULTS:
      Patients with renal dysfunction more often had: diabetes mellitus (56% vs. 16%,
      P=0.02), prolonged symptoms (6.8 d vs. 3.5 d, P=0.01), lower hemoglobin (11.1
      g/dL vs. 13.4 g/dL, P=0.01), and more often right colonic involvement (56% vs.
      19%, P=0.03). Renal dysfunction patients also had longer hospitalization days
      (median 15 d vs. 4 d, P=0.045). However, there was no statistical significance in
      the rate of either surgery or mortality between these 2 groups (P>0.05).
      Univariate analysis showed that renal dysfunction, sex, emergency department
      referral, presentation with abdominal pain were significant for adverse outcome
      (P<0.1). Multivariate analysis revealed that male sex conveyed 9.5-fold risk
      (P=0.01) and renal dysfunction conveyed 8.5-fold risk (P=0.03) for adverse
      outcomes. CONCLUSIONS: Nonpostoperative IC patients with concurrent renal
      dysfunction had distinct clinical profiles. Multivariate analysis showed that
      male patients had 9.5-fold and renal dysfunction patients had 8.5-fold increased 
      risk for adverse outcomes. Although IC is often self-limited, our data warrants
      special attention and aggressive therapy in treating these patients.
FAU - Lee, Tsung-Chun
AU  - Lee TC
AD  - Department of Internal Medicine, National Taiwan University Hospital
      daggerGraduate Institute of Physiology, College of Medicine, National Taiwan
      University, Taipei, Taiwan.
FAU - Wang, Hsiu-Po
AU  - Wang HP
FAU - Chiu, Han-Mo
AU  - Chiu HM
FAU - Lien, Wan-Ching
AU  - Lien WC
FAU - Chen, Mei-Jyh
AU  - Chen MJ
FAU - Yu, Linda C H
AU  - Yu LC
FAU - Sun, Chia-Tung
AU  - Sun CT
FAU - Lin, Jaw-Town
AU  - Lin JT
FAU - Wu, Ming-Shiang
AU  - Wu MS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Gastroenterol
JT  - Journal of clinical gastroenterology
JID - 7910017
RN  - 0 (Hemoglobins)
SB  - IM
CIN - J Clin Gastroenterol. 2011 Mar;45(3):295. PMID: 20733516
MH  - Abdominal Pain/*etiology
MH  - Academic Medical Centers
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Colitis, Ischemic/etiology/mortality/*pathology
MH  - Diabetes Mellitus/physiopathology
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Hemoglobins/metabolism
MH  - Humans
MH  - Kidney Diseases/*complications
MH  - Length of Stay
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Sex Factors
MH  - Taiwan
MH  - Young Adult
EDAT- 2010/03/11 06:00
MHDA- 2010/08/04 06:00
CRDT- 2010/03/11 06:00
PHST- 2010/03/11 06:00 [entrez]
PHST- 2010/03/11 06:00 [pubmed]
PHST- 2010/08/04 06:00 [medline]
AID - 10.1097/MCG.0b013e3181d347b9 [doi]
PST - ppublish
SO  - J Clin Gastroenterol. 2010 May-Jun;44(5):e96-100. doi:
      10.1097/MCG.0b013e3181d347b9.


PMID- 20215772
OWN - NLM
STAT- MEDLINE
DCOM- 20100608
LR  - 20160519
IS  - 1663-2826 (Electronic)
IS  - 1663-2818 (Linking)
VI  - 73
IP  - 4
DP  - 2010
TI  - Relative bioavailability of two drug products of somatropin obtained from either 
      the milk of transgenic cows or bacterial culture.
PG  - 258-64
LID - 10.1159/000284390 [doi]
AB  - BACKGROUND: Our objective was to assess the relative bioavailability of the first
      somatropin produced in transgenic cloned cows that carry the human growth hormone
      (GH) gene (Biohormon) and somatropin produced in Escherichia coli culture (HHT), 
      the procedure most frequently used for the commercial production of the hormone. 
      METHODS: Upon approval by an independent ethics committee and the National
      Regulatory Agency of Argentina, we compared the time-concentration profiles of
      somatropin in 24 healthy volunteers, in a randomized, 2-period, 2-sequence
      crossover design after inhibition of endogenous GH secretion with lanreotide, a
      long-acting somastostatin analogue. After the subcutaneous administration of 1.33
      mg of each formulation, serum somatropin was analyzed by chemiluminescent
      immunoassay and IGF-I by immunoradiometric assay. Safety was assessed by clinical
      and laboratory parameters. Pharmacokinetic parameters were calculated with Win
      Nonlin 5.2 using a non-compartmental model and bioequivalence was assessed.
      RESULTS: The test/reference ratios of AUC, AUC(last) and C(max) were 106.4 (90%
      CI = 100.2-112.9), 105.3 (90% CI = 99.1-111.8) and 105.49 (90% CI = 92.6-120.1), 
      respectively. No serious adverse events were reported and no GH antibodies were
      detected. CONCLUSION: This study demonstrates that a single dose of Biohormon,
      the first product with somatropin obtained from milk of transgenic mammals, is
      bioequivalent to the reference product HHT according to standard criteria.
CI  - Copyright (c) 2010 S. Karger AG, Basel.
FAU - Farias, J
AU  - Farias J
AD  - Bio Sidus SA, Buenos Aires, Argentina. javiermfarias @ arnet.com.ar
FAU - Feleder, E
AU  - Feleder E
FAU - Gonzalez, E
AU  - Gonzalez E
FAU - Halabe, K
AU  - Halabe K
FAU - Criscuolo, M E
AU  - Criscuolo ME
FAU - Bergada, I
AU  - Bergada I
FAU - Diez, R A
AU  - Diez RA
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20100309
PL  - Switzerland
TA  - Horm Res Paediatr
JT  - Hormone research in paediatrics
JID - 101525157
RN  - 0 (Recombinant Proteins)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - 9002-72-6 (Growth Hormone)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Animals, Genetically Modified
MH  - Area Under Curve
MH  - Biological Availability
MH  - Cattle
MH  - Cross-Over Studies
MH  - Dwarfism, Pituitary/metabolism/therapy
MH  - Female
MH  - Growth Hormone/biosynthesis/blood/*pharmacokinetics
MH  - Half-Life
MH  - Hormone Replacement Therapy/methods
MH  - Humans
MH  - Insulin-Like Growth Factor I/analysis
MH  - Male
MH  - Milk/metabolism
MH  - Recombinant Proteins/biosynthesis/blood/*pharmacokinetics
EDAT- 2010/03/11 06:00
MHDA- 2010/06/09 06:00
CRDT- 2010/03/11 06:00
PHST- 2009/05/06 00:00 [received]
PHST- 2009/07/07 00:00 [accepted]
PHST- 2010/03/11 06:00 [entrez]
PHST- 2010/03/11 06:00 [pubmed]
PHST- 2010/06/09 06:00 [medline]
AID - 000284390 [pii]
AID - 10.1159/000284390 [doi]
PST - ppublish
SO  - Horm Res Paediatr. 2010;73(4):258-64. doi: 10.1159/000284390. Epub 2010 Mar 9.


PMID- 20215620
OWN - NLM
STAT- MEDLINE
DCOM- 20100610
LR  - 20181113
IS  - 0956-4624 (Print)
IS  - 0956-4624 (Linking)
VI  - 21
IP  - 3
DP  - 2010 Mar
TI  - A qualitative assessment of perspectives on the inclusion of adolescents in HIV
      vaccine trials in South Africa.
PG  - 172-6
LID - 10.1258/ijsa.2009.008484 [doi]
AB  - Adolescents are at high risk for HIV acquisition, and thus need to be included in
      HIV vaccine trials. In preparation for inclusion of adolescents in HIV vaccine
      trials in an urban community in Cape Town with a high antenatal HIV prevalence,
      the study assessed the attitudes towards the inclusion of adolescents in HIV
      vaccine trials. A total of 18 focus group discussions were conducted using a
      semistructured interview guide. The participants (n = 200) were adolescents,
      young adults, parents and other key informants. Participants from all groups
      welcomed the inclusion of adolescents in HIV vaccine trials due to their
      high-risk status. There were, however, concerns about sexual disinhibition, fear 
      of side-effects, fear of HIV testing and disclosure of HIV status, mistrust of
      nurses and clinics. The study highlighted a number of ethical and social issues
      that need to be addressed before the trials.
FAU - Jaspan, H B
AU  - Jaspan HB
AD  - Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine,
      University of Cape Town, Cape Town, South Africa. heather.jaspan@sbri.org
FAU - Soka, N F
AU  - Soka NF
FAU - Mathews, C
AU  - Mathews C
FAU - Flisher, A J
AU  - Flisher AJ
FAU - Mark, D
AU  - Mark D
FAU - Middelkoop, K
AU  - Middelkoop K
FAU - Wood, R
AU  - Wood R
FAU - Bekker, L-G
AU  - Bekker LG
LA  - eng
GR  - L30 AI062216/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - Int J STD AIDS
JT  - International journal of STD & AIDS
JID - 9007917
RN  - 0 (AIDS Vaccines)
SB  - IM
MH  - AIDS Vaccines/*therapeutic use
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Clinical Trials, Phase II as Topic
MH  - Data Collection
MH  - Female
MH  - HIV Infections/*prevention & control
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Patient Selection
MH  - Risk-Taking
MH  - South Africa/epidemiology
MH  - Urban Population
PMC - PMC3878910
MID - NIHMS535360
EDAT- 2010/03/11 06:00
MHDA- 2010/06/11 06:00
CRDT- 2010/03/11 06:00
PHST- 2010/03/11 06:00 [entrez]
PHST- 2010/03/11 06:00 [pubmed]
PHST- 2010/06/11 06:00 [medline]
AID - 21/3/172 [pii]
AID - 10.1258/ijsa.2009.008484 [doi]
PST - ppublish
SO  - Int J STD AIDS. 2010 Mar;21(3):172-6. doi: 10.1258/ijsa.2009.008484.


PMID- 20215550
OWN - NLM
STAT- MEDLINE
DCOM- 20100622
LR  - 20101118
IS  - 1557-3265 (Electronic)
IS  - 1078-0432 (Linking)
VI  - 16
IP  - 6
DP  - 2010 Mar 15
TI  - GCP data quality for early clinical development.
PG  - 1756-63
LID - 10.1158/1078-0432.CCR-09-3267 [doi]
AB  - Good Clinical Practice (GCP) provides an internationally accepted standard to
      ensure subject safety and data quality in clinical trials. Much of GCP parallels 
      ethical considerations that have accumulated in successive versions of the World 
      Medical Association's Declaration of Helsinki. This document advocates for
      preservation of rights, safety, and well-being of human study participants. By
      contrast, GCP data quality provisions follow from evolution in the United States 
      drug regulatory system during the 1960s. Evidence of fraudulent or otherwise
      biased data-gathering ultimately led to U.S. Food and Drug Administration (FDA)
      data integrity regulations that were subsequently embraced as GCP principles in
      the Declaration of Helsinki. This manuscript summarizes GCP data quality
      provisions and describes practices that clinical site investigators can adopt to 
      comply with these principles and to prevent adverse audit findings in the event
      of a regulatory inspection.
FAU - Rock, Edwin P
AU  - Rock EP
AD  - Otsuka Pharmaceutical Development and Commercialization, Inc., Princeton, New
      Jersey, USA.
FAU - Molloy, Vernette J
AU  - Molloy VJ
FAU - Humphrey, Jeffrey S
AU  - Humphrey JS
LA  - eng
PT  - Journal Article
DEP - 20100309
PL  - United States
TA  - Clin Cancer Res
JT  - Clinical cancer research : an official journal of the American Association for
      Cancer Research
JID - 9502500
RN  - 0 (Drugs, Investigational)
SB  - IM
MH  - Clinical Trials as Topic/*legislation & jurisprudence/*standards
MH  - Drugs, Investigational/*standards
MH  - Guidelines as Topic/*standards
MH  - *Health Facility Administration
MH  - Humans
MH  - Research Design/*standards
EDAT- 2010/03/11 06:00
MHDA- 2010/06/23 06:00
CRDT- 2010/03/11 06:00
PHST- 2010/03/11 06:00 [entrez]
PHST- 2010/03/11 06:00 [pubmed]
PHST- 2010/06/23 06:00 [medline]
AID - 1078-0432.CCR-09-3267 [pii]
AID - 10.1158/1078-0432.CCR-09-3267 [doi]
PST - ppublish
SO  - Clin Cancer Res. 2010 Mar 15;16(6):1756-63. doi: 10.1158/1078-0432.CCR-09-3267.
      Epub 2010 Mar 9.


PMID- 20215097
OWN - NLM
STAT- MEDLINE
DCOM- 20100511
LR  - 20100310
IS  - 1760-1703 (Print)
IS  - 1760-1703 (Linking)
VI  - 8
IP  - 1
DP  - 2010 Mar
TI  - [Voting by cognitively impaired persons: legal and ethical issues].
PG  - 33-42
LID - 10.1684/pnv.2009.0181 [doi]
AB  - In democratic countries, cognitively impaired persons are a substantial and
      growing group of citizens. Most of them are citizens with dementia. In dementia, 
      cognitive impairment induces a loss of some capacities, resulting in
      vulnerability and increased need for assistance. Voting by cognitively impaired
      persons raises any questions about the integrity of the electoral process, the
      risk of fraud and the respect of their citizenship. In France, the law is not
      definite about the voting of cognitively impaired persons. An objective
      assessment for voting capacity may be useful both for professionals in charge of 
      voting organisation and for guardianship judge in order to help him in his
      decision to remove or keep the voting right of persons placed under guardianship.
      Assessing the reality of voting by cognitively impaired citizens is necessary to 
      advance respect for their right to vote.
FAU - Bosquet, Antoine
AU  - Bosquet A
AD  - Service de medecine interne, CHU Louis Mourier, Universite Paris 7 Denis Diderot,
      Colombes, France. antoine.bosquet@lmr.aphp.fr
FAU - Medjkane, Amar
AU  - Medjkane A
FAU - Vinceneux, Philippe
AU  - Vinceneux P
FAU - Mahe, Isabelle
AU  - Mahe I
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Le vote des sujets ayant des alterations des fonctions cognitives : aspects
      legislatifs et ethiques.
PL  - France
TA  - Psychol Neuropsychiatr Vieil
JT  - Psychologie & neuropsychiatrie du vieillissement
JID - 101203421
SB  - IM
MH  - Cognition Disorders/*psychology
MH  - Dementia/psychology
MH  - *Ethics
MH  - France
MH  - Humans
MH  - *Politics
RF  - 30
EDAT- 2010/03/11 06:00
MHDA- 2010/05/12 06:00
CRDT- 2010/03/11 06:00
PHST- 2010/03/11 06:00 [entrez]
PHST- 2010/03/11 06:00 [pubmed]
PHST- 2010/05/12 06:00 [medline]
AID - pnv.2009.0181 [pii]
AID - 10.1684/pnv.2009.0181 [doi]
PST - ppublish
SO  - Psychol Neuropsychiatr Vieil. 2010 Mar;8(1):33-42. doi: 10.1684/pnv.2009.0181.


PMID- 20214657
OWN - NLM
STAT- MEDLINE
DCOM- 20100806
LR  - 20191111
IS  - 2212-4039 (Electronic)
IS  - 1872-2113 (Linking)
VI  - 4
IP  - 2
DP  - 2010 Jun
TI  - Use of In Vitro-In Vivo Correlation (IVIVC) to facilitate the development of
      polymer-based controlled release injectable formulation.
PG  - 94-104
AB  - In Vitro-In Vivo Correlation (IVIVC) is being increasingly used to predict
      bioperformance of dosage forms without conducting animal and/or human studies
      which are not only time-consuming and expensive but also might be considered
      ethically undesirable. The main aim of IVIVC methods is to develop in vitro drug 
      release methods which are simple, robust, reproducible, inexpensive, in
      compliance with compendial and regulatory requirements and finally can be used in
      lieu of in vivo studies to direct formulation selection. This review provides a
      summary of currently marketed polymeric depot products and the patents related to
      these drug delivery systems in addition to currently available in vitro release
      methods used to study drug release from injectable controlled release drug
      delivery systems, currently available IVIVC methods and some examples of
      successful IVIVC for small molecules, peptides and proteins formulated in
      controlled release formulations administered subcutaneously or intramuscularly.
FAU - Mitra, Amitava
AU  - Mitra A
AD  - Biopharmaceutics Research and Parenteral Delivery, Pharmaceutical R&D, Merck &
      Co., West Point, PA 19486-0004, USA. amitava_mitra@merck.com
FAU - Wu, Yunhui
AU  - Wu Y
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Recent Pat Drug Deliv Formul
JT  - Recent patents on drug delivery & formulation
JID - 101462399
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Pharmaceutical Preparations)
RN  - 0 (Polymers)
SB  - IM
MH  - Animals
MH  - Delayed-Action Preparations
MH  - *Drug Delivery Systems
MH  - *Drug Design
MH  - Humans
MH  - Injections
MH  - Models, Theoretical
MH  - Patents as Topic
MH  - Pharmaceutical Preparations/administration & dosage/chemistry
MH  - Polymers/*chemistry
MH  - Reproducibility of Results
RF  - 63
EDAT- 2010/03/11 06:00
MHDA- 2010/08/07 06:00
CRDT- 2010/03/11 06:00
PHST- 2009/10/24 00:00 [received]
PHST- 2009/02/03 00:00 [accepted]
PHST- 2010/03/11 06:00 [entrez]
PHST- 2010/03/11 06:00 [pubmed]
PHST- 2010/08/07 06:00 [medline]
AID - BSP/DDF/EPUB/00004 [pii]
AID - 10.2174/187221110791185024 [doi]
PST - ppublish
SO  - Recent Pat Drug Deliv Formul. 2010 Jun;4(2):94-104. doi:
      10.2174/187221110791185024.


PMID- 20214516
OWN - NLM
STAT- MEDLINE
DCOM- 20100616
LR  - 20201222
IS  - 1744-8328 (Electronic)
IS  - 1473-7140 (Linking)
VI  - 10
IP  - 3
DP  - 2010 Mar
TI  - Quality-of-life considerations in treatment of unresectable, recurrent head and
      neck cancer.
PG  - 345-52
LID - 10.1586/era.10.13 [doi]
AB  - Recurrent, unresectable head and neck squamous cancer is a complex problem.
      Evidence for the efficacy of treatment is scant in this area and given the large 
      number of patient and tumor variables involved in the recurrent tumor, several
      factors play a role in deciding the choice of management. The results of
      treatment are very poor and associated with significant toxicity. Thus, the
      quality of life outcome following treatment should play a major role in the
      choice of treatment. Unfortunately, generation of quality-of-life data is
      hampered by several factors, not least of which are the ethical issues raised by 
      end of life care. This article reviews the relevant literature, summarizes
      existing evidence and draws conclusions, identifies gaps in the knowledge and
      offers guidance for further research.
FAU - McLarnon, Claire
AU  - McLarnon C
AD  - Otolaryngology-Head & Neck Surgery, Newcastle upon Tyne Hospitals NHS Trust,
      Freeman Road, Newcastle upon Tyne, UK. clairemrennison@hotmail.com
FAU - Kulloo, Praneta
AU  - Kulloo P
FAU - Mehanna, Hisham
AU  - Mehanna H
FAU - Kelly, Charles
AU  - Kelly C
FAU - Paleri, Vinidh
AU  - Paleri V
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Expert Rev Anticancer Ther
JT  - Expert review of anticancer therapy
JID - 101123358
SB  - IM
MH  - Head and Neck Neoplasms/physiopathology/*therapy
MH  - Humans
MH  - Neoplasm Recurrence, Local
MH  - Palliative Care/methods
MH  - *Quality of Life
MH  - Terminal Care/ethics/*methods
MH  - Treatment Outcome
RF  - 43
EDAT- 2010/03/11 06:00
MHDA- 2010/06/17 06:00
CRDT- 2010/03/11 06:00
PHST- 2010/03/11 06:00 [entrez]
PHST- 2010/03/11 06:00 [pubmed]
PHST- 2010/06/17 06:00 [medline]
AID - 10.1586/era.10.13 [doi]
PST - ppublish
SO  - Expert Rev Anticancer Ther. 2010 Mar;10(3):345-52. doi: 10.1586/era.10.13.


PMID- 20214432
OWN - NLM
STAT- MEDLINE
DCOM- 20100609
LR  - 20220409
IS  - 1745-2422 (Electronic)
IS  - 1743-4440 (Linking)
VI  - 7
IP  - 2
DP  - 2010 Mar
TI  - Automated detection of diabetic retinopathy: barriers to translation into
      clinical practice.
PG  - 287-96
LID - 10.1586/erd.09.76 [doi]
AB  - Automated identification of diabetic retinopathy (DR), the primary cause of
      blindness and visual loss for those aged 18-65 years, from color images of the
      retina has enormous potential to increase the quality, cost-effectiveness and
      accessibility of preventative care for people with diabetes. Through advanced
      image analysis techniques, retinal images are analyzed for abnormalities that
      define and correlate with the severity of DR. Translating automated DR detection 
      into clinical practice will require surmounting scientific and nonscientific
      barriers. Scientific concerns, such as DR detection limits compared with human
      experts, can be studied and measured. Ethical, legal and political issues can be 
      addressed, but are difficult or impossible to measure. The primary objective of
      this review is to survey the methods, potential benefits and limitations of
      automated detection in order to better manage translation into clinical practice,
      based on extensive experience with the systems we have developed.
FAU - Abramoff, Michael D
AU  - Abramoff MD
AD  - Department of Ophthalmology and Visual Sciences, University of Iowa, 11290C PFP
      UIHC, 200 Hawkins Drive, Iowa City, IA 52242, USA. michael-abramoff@uiowa.edu
FAU - Niemeijer, Meindert
AU  - Niemeijer M
FAU - Russell, Stephen R
AU  - Russell SR
LA  - eng
GR  - R01 EY019112-02/EY/NEI NIH HHS/United States
GR  - R01 EY018853-02/EY/NEI NIH HHS/United States
GR  - R01 EY019112/EY/NEI NIH HHS/United States
GR  - R01 EY017066-03/EY/NEI NIH HHS/United States
GR  - R01 EY017066-04/EY/NEI NIH HHS/United States
GR  - R01 EY018853-01A2/EY/NEI NIH HHS/United States
GR  - R01 EY019112-01A2/EY/NEI NIH HHS/United States
GR  - R01 EY017066-01/EY/NEI NIH HHS/United States
GR  - R01 EY018853/EY/NEI NIH HHS/United States
GR  - R01 EY017066/EY/NEI NIH HHS/United States
GR  - R01 EY017066-02/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Expert Rev Med Devices
JT  - Expert review of medical devices
JID - 101230445
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Algorithms
MH  - *Artificial Intelligence
MH  - Diabetic Retinopathy/*diagnosis
MH  - Female
MH  - Humans
MH  - Image Enhancement/*methods
MH  - Image Interpretation, Computer-Assisted/*methods
MH  - Middle Aged
MH  - Pattern Recognition, Automated/*methods
MH  - Reproducibility of Results
MH  - Retinoscopy/*methods
MH  - Sensitivity and Specificity
MH  - Young Adult
PMC - PMC2911785
MID - NIHMS207249
EDAT- 2010/03/11 06:00
MHDA- 2010/06/10 06:00
CRDT- 2010/03/11 06:00
PHST- 2010/03/11 06:00 [entrez]
PHST- 2010/03/11 06:00 [pubmed]
PHST- 2010/06/10 06:00 [medline]
AID - 10.1586/erd.09.76 [doi]
PST - ppublish
SO  - Expert Rev Med Devices. 2010 Mar;7(2):287-96. doi: 10.1586/erd.09.76.


PMID- 20214250
OWN - NLM
STAT- MEDLINE
DCOM- 20100504
LR  - 20190923
IS  - 1547-1896 (Print)
IS  - 0893-7400 (Linking)
VI  - 23
IP  - 2
DP  - 2010 Feb
TI  - Why physician assistants should consider joining the hospital ethics committee.
PG  - 55-6, 58
FAU - Anderson, Jim
AU  - Anderson J
AD  - Department of Orthopedics, Seattle Children's Hospital, Seattle, Washington, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - JAAPA
JT  - JAAPA : official journal of the American Academy of Physician Assistants
JID - 9513102
MH  - *Ethics Committees, Clinical
MH  - Humans
MH  - *Physician Assistants
EDAT- 2010/03/11 06:00
MHDA- 2010/05/05 06:00
CRDT- 2010/03/11 06:00
PHST- 2010/03/11 06:00 [entrez]
PHST- 2010/03/11 06:00 [pubmed]
PHST- 2010/05/05 06:00 [medline]
AID - 10.1097/01720610-201002000-00011 [doi]
PST - ppublish
SO  - JAAPA. 2010 Feb;23(2):55-6, 58. doi: 10.1097/01720610-201002000-00011.


PMID- 20213821
OWN - NLM
STAT- MEDLINE
DCOM- 20101028
LR  - 20100723
IS  - 1098-2345 (Electronic)
IS  - 0275-2565 (Linking)
VI  - 72
IP  - 9
DP  - 2010 Sep
TI  - Ethical issues faced by field primatologists: asking the relevant questions.
PG  - 754-71
LID - 10.1002/ajp.20814 [doi]
AB  - Field primatologists face unusual ethical issues. We study animals rather than
      people and receive research approval from animal care rather than ethics
      committees. However, animal care evaluation forms are developed from concerns
      about laboratory animal research and are based on the "Three R's" for humane
      treatment of captive experimental subjects (replacement, reduction and
      refinement), which are only debatably relevant to field research. Scientists who 
      study wild, free-ranging primates in host countries experience many ethical
      dilemmas seldom dealt with in animal care forms. This paper reviews the ethical
      issues many field primatologists say they face and how these might be better
      addressed by animal care forms. The ethical issues arising for field researchers 
      are divided into three categories: "Presence, Protocols and People" and for each 
      the most frequent issues are described. The most commonly mentioned ethical
      concern arising from our presence in the field is the possibility of disease
      transmission. Although most primate field studies employ only observational
      protocols, the practice of habituating our study animals to close human presence 
      is an ethical concern for many since it can lessen the animals' fear of all
      humans, thereby facilitating undesirable behaviors (e.g., crop-raiding) and
      rendering them vulnerable to harm. Field primatologists who work in host
      countries must observe national laws and local traditions. As conservationists,
      primatologists must often negotiate between the resource needs and cultural
      practices of local people and the interests of the nonhuman primates. Many say
      they face more ethical dilemmas arising from human interactions than from
      research on the animals per se. This review concludes with suggestions for
      relevant questions to ask on animal care forms, and actions that field
      primatologists can take to better inform animal care committees about the common 
      ethical issues we experience as well as how to develop guidelines for addressing 
      them.
CI  - (c) 2010 Wiley-Liss, Inc.
FAU - Fedigan, Linda Marie
AU  - Fedigan LM
AD  - Department of Anthropology, University of Calgary, Calgary, Alberta, Canada.
      Fedigan@ucalgary.ca
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Am J Primatol
JT  - American journal of primatology
JID - 8108949
SB  - IM
MH  - Animal Care Committees
MH  - *Animal Welfare
MH  - Animals
MH  - *Animals, Wild
MH  - Behavior, Animal/physiology
MH  - Disease Transmission, Infectious/*veterinary
MH  - *Ethics, Research
MH  - *Primates
MH  - Zoology/*ethics/methods
MH  - Zoonoses/*transmission
EDAT- 2010/03/10 06:00
MHDA- 2010/10/29 06:00
CRDT- 2010/03/10 06:00
PHST- 2010/03/10 06:00 [entrez]
PHST- 2010/03/10 06:00 [pubmed]
PHST- 2010/10/29 06:00 [medline]
AID - 10.1002/ajp.20814 [doi]
PST - ppublish
SO  - Am J Primatol. 2010 Sep;72(9):754-71. doi: 10.1002/ajp.20814.


PMID- 20213566
OWN - NLM
STAT- MEDLINE
DCOM- 20100602
LR  - 20141120
IS  - 1744-1706 (Electronic)
IS  - 1744-1692 (Linking)
VI  - 5
IP  - 2
DP  - 2010
TI  - Okukkera Ng'omuzungu (lost in translation): understanding the social value of
      global health research for HIV/AIDS research participants in Uganda.
PG  - 164-80
LID - 10.1080/17441690903510658 [doi]
AB  - As major global governance entities begin to re-assess the structure and goals of
      health research in resource-poor settings, social science can make a vital
      contribution by expanding the traditional field of research ethics to include new
      concepts such as the social value of global health research. This essay recasts
      the definition of social value in health research by shifting away from the
      official spaces where research occurs and towards the meaning of research as it
      is produced in the everyday spaces inhabited by the local community. We present
      three cases that reveal the local view of the social value of health research for
      Ugandans: autonomy and consent; the concept of risk; and what appears to be a
      classic case of therapeutic misconception between researcher and informant.
      Ultimately what we see, we argue, is the fundamental collision of the logic of
      biomedical research with the logic of local social relationships, that is,
      researchers perform their role as a transaction, while participants anticipate
      their involvement in research to be transformative. When we expand the analysis
      of the impact of research from the research/participant dyad to shifting
      community networks, we conclude that didactic models, such as the therapeutic
      misconception, are of limited utility for understanding the social value of
      global health research in resource-poor settings.
FAU - Stewart, K
AU  - Stewart K
AD  - Department of Anthropology and Global Health Studies Program, Northwestern
      University, Evanston, IL, USA. kstewart@northwestern.edu
FAU - Sewankambo, N
AU  - Sewankambo N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Glob Public Health
JT  - Global public health
JID - 101256323
SB  - IM
MH  - Biomedical Research/*ethics
MH  - *Comprehension
MH  - Global Health
MH  - *HIV Infections
MH  - Humans
MH  - Informed Consent
MH  - Interviews as Topic
MH  - Language
MH  - Risk Assessment
MH  - *Social Values
MH  - Uganda
EDAT- 2010/03/10 06:00
MHDA- 2010/06/03 06:00
CRDT- 2010/03/10 06:00
PHST- 2010/03/10 06:00 [entrez]
PHST- 2010/03/10 06:00 [pubmed]
PHST- 2010/06/03 06:00 [medline]
AID - 919675874 [pii]
AID - 10.1080/17441690903510658 [doi]
PST - ppublish
SO  - Glob Public Health. 2010;5(2):164-80. doi: 10.1080/17441690903510658.


PMID- 20213565
OWN - NLM
STAT- MEDLINE
DCOM- 20100602
LR  - 20141120
IS  - 1744-1706 (Electronic)
IS  - 1744-1692 (Linking)
VI  - 5
IP  - 2
DP  - 2010
TI  - Evolving values in ethics and global health research.
PG  - 154-63
LID - 10.1080/17441690903436599 [doi]
AB  - Over the past 25 years, the ethics of international health research have shifted 
      from addressing narrow issues such as cultural differences in informed consent
      practices towards a greater emphasis on development and social justice. We
      anticipate that the next 'era' in international research ethics will involve an
      intensification of this focus on the role of research in achieving global
      justice. Three values, in particular, will shape how ethics considerations should
      evolve: solidarity; respect for Southern innovation; and commitment to action. We
      expect continuing debate on whether researchers and research sponsors should
      recognise more than a minimal set of obligations for the care and benefit of
      research participants and their communities. As the debate about the role of
      research in development intensifies, we expect to see new and more elaborate
      mechanisms for financing on-going access to beneficial interventions, ancillary
      care and other research-related benefits, as well as a greater involvement in
      research funding by developing country governments and private foundations.
      Ethics review and oversight need to reflect on these new values and on ways of
      operationalising them, or risk becoming marginalised in the research process.
FAU - Ijsselmuiden, C B
AU  - Ijsselmuiden CB
AD  - Council on Health Research for Development, Geneva, Switzerland. carel@cohred.org
FAU - Kass, N E
AU  - Kass NE
FAU - Sewankambo, K N
AU  - Sewankambo KN
FAU - Lavery, J V
AU  - Lavery JV
LA  - eng
PT  - Journal Article
PL  - England
TA  - Glob Public Health
JT  - Global public health
JID - 101256323
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Developing Countries
MH  - *Global Health
MH  - Humans
MH  - *Social Justice
EDAT- 2010/03/10 06:00
MHDA- 2010/06/03 06:00
CRDT- 2010/03/10 06:00
PHST- 2010/03/10 06:00 [entrez]
PHST- 2010/03/10 06:00 [pubmed]
PHST- 2010/06/03 06:00 [medline]
AID - 919676304 [pii]
AID - 10.1080/17441690903436599 [doi]
PST - ppublish
SO  - Glob Public Health. 2010;5(2):154-63. doi: 10.1080/17441690903436599.


PMID- 20213534
OWN - NLM
STAT- MEDLINE
DCOM- 20120209
LR  - 20181113
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 17
IP  - 2
DP  - 2011 Jun
TI  - Ethics in 15 min per week.
PG  - 289-97
LID - 10.1007/s11948-010-9197-3 [doi]
AB  - The demand for science trainees to have appropriate responsible conduct of
      research instruction continues to increase the attention shown by federal
      agencies and graduate school programs to the development of effective ethics
      curriculums. However, it is important to consider that the main learning
      environment for science graduate students and post-doctoral research fellows is
      within a laboratory setting. Here we discuss an internal laboratory program of
      weekly 15-minute ethics discussions implemented and used over the last 3 years in
      addition to the graduate school's program of scientific integrity training.
      During this time, the environment and culture within our laboratory has changed
      to place greater emphasis on the ethical implications of our own research and the
      research we evaluate. We still struggle with how to accurately assess this
      behavioral change; although, we present preliminary survey results on the
      evaluation and impact of this style of curriculum for ethics instruction in our
      laboratory.
FAU - Peiffer, Ann M
AU  - Peiffer AM
AD  - Department of Radiology, Wake Forest University School of Medicine, Medical
      Center Blvd., PP1 7th Floor, Winston-Salem, NC 27157, USA. apeiffer@wfubmc.edu
FAU - Hugenschmidt, Christina E
AU  - Hugenschmidt CE
FAU - Laurienti, Paul J
AU  - Laurienti PJ
LA  - eng
GR  - F32 NS054472/NS/NINDS NIH HHS/United States
GR  - K08 NS042568/NS/NINDS NIH HHS/United States
GR  - NS042568/NS/NINDS NIH HHS/United States
GR  - NS054472/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100307
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Curriculum
MH  - Education, Graduate
MH  - Ethics, Research/*education
MH  - Humans
MH  - Research/*education
MH  - Science/*education/ethics
MH  - *Social Responsibility
MH  - Teaching/*methods
MH  - United States
PMC - PMC3904356
MID - NIHMS402456
EDAT- 2010/03/10 06:00
MHDA- 2012/02/10 06:00
CRDT- 2010/03/10 06:00
PHST- 2009/01/27 00:00 [received]
PHST- 2010/02/18 00:00 [accepted]
PHST- 2010/03/10 06:00 [entrez]
PHST- 2010/03/10 06:00 [pubmed]
PHST- 2012/02/10 06:00 [medline]
AID - 10.1007/s11948-010-9197-3 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2011 Jun;17(2):289-97. doi: 10.1007/s11948-010-9197-3. Epub 2010 
      Mar 7.


PMID- 20213206
OWN - NLM
STAT- MEDLINE
DCOM- 20110218
LR  - 20220410
IS  - 1525-1497 (Electronic)
IS  - 0884-8734 (Linking)
VI  - 25
IP  - 7
DP  - 2010 Jul
TI  - Supporting patient autonomy: the importance of clinician-patient relationships.
PG  - 741-5
LID - 10.1007/s11606-010-1292-2 [doi]
AB  - Personal autonomy is widely valued. Recognition of its vulnerability in health
      care contexts led to the inclusion of respect for autonomy as a key concern in
      biomedical ethics. The principle of respect for autonomy is usually associated
      with allowing or enabling patients to make their own decisions about which health
      care interventions they will or will not receive. In this paper, we suggest that 
      a strong focus on decision situations is problematic, especially when combined
      with a tendency to stress the importance of patients' independence in choosing.
      It distracts attention from other important aspects of and challenges to autonomy
      in health care. Relational understandings of autonomy attempt to explain both the
      positive and negative implications of social relationships for individuals'
      autonomy. They suggest that many health care practices can affect autonomy by
      virtue of their effects not only on patients' treatment preferences and choices, 
      but also on their self-identities, self-evaluations and capabilities for
      autonomy. Relational understandings de-emphasise independence and facilitate
      well-nuanced distinctions between forms of clinical communication that support
      and that undermine patients' autonomy. These understandings support recognition
      of the value of good patient-professional relationships and can enrich the
      specification of the principle of respect for autonomy.
FAU - Entwistle, Vikki A
AU  - Entwistle VA
AD  - Social Dimensions of Health Institute, Universities of Dundee and St Andrews,
      Dundee, Scotland, UK. v.entwistle@cpse.dundee.ac.uk
FAU - Carter, Stacy M
AU  - Carter SM
FAU - Cribb, Alan
AU  - Cribb A
FAU - McCaffery, Kirsten
AU  - McCaffery K
LA  - eng
GR  - 086034/WT_/Wellcome Trust/United Kingdom
GR  - HSRU2/CSO_/Chief Scientist Office/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100306
PL  - United States
TA  - J Gen Intern Med
JT  - Journal of general internal medicine
JID - 8605834
SB  - IM
CIN - J Gen Intern Med. 2010 Jul;25(7):639. PMID: 20473641
MH  - Humans
MH  - Patient Rights/*ethics
MH  - *Personal Autonomy
MH  - Physician-Patient Relations/*ethics
PMC - PMC2881979
EDAT- 2010/03/10 06:00
MHDA- 2011/02/22 06:00
CRDT- 2010/03/10 06:00
PHST- 2009/10/06 00:00 [received]
PHST- 2010/02/02 00:00 [accepted]
PHST- 2010/01/28 00:00 [revised]
PHST- 2010/03/10 06:00 [entrez]
PHST- 2010/03/10 06:00 [pubmed]
PHST- 2011/02/22 06:00 [medline]
AID - 10.1007/s11606-010-1292-2 [doi]
PST - ppublish
SO  - J Gen Intern Med. 2010 Jul;25(7):741-5. doi: 10.1007/s11606-010-1292-2. Epub 2010
      Mar 6.


PMID- 20212394
OWN - NLM
STAT- MEDLINE
DCOM- 20100803
LR  - 20151119
IS  - 0026-4946 (Print)
IS  - 0026-4946 (Linking)
VI  - 62
IP  - 1
DP  - 2010 Feb
TI  - Observational study on the performance of the Narhinel method (nasal aspirator
      and physiological saline solution) versus physiological saline solution in the
      prevention of recurrences of viral rhinitis and associated complications of the
      upper respiratory tract infections (URTI), with a special focus on acute
      rhinosinusitis and acute otitis of the middle ear.
PG  - 9-16, 17-21
AB  - AIM: The aim of this study was to assess the validity of Narhinel method in the
      prevention of recurrences of viral rhinitis and of any associated sequelae, in
      particular acute otitis of the middle ear (AOM) and acute rhinosinusitis (AR).
      METHODS: This was a prospective observational study, in children aged from two
      months to two years, observed for five months during the cold season and carried 
      out by family pediatricians (FIMP association) in Friuli Venezia Giulia, Italy.
      The study enrolled 435 patients. The observed population consisted of two groups:
      the first one of 238 children treated with Narhinel method and the second one of 
      197 patients treated only with the physiological saline solution. In compliance
      with the guidelines of an observational trial, the children were prescribed the
      therapeutic treatments used as a routine. The patients were recruited for the
      trial after the responsible parent had signed the informed consent form. The
      study protocol had been approved by the Ethics Committee of the area of
      Pordenone. In order to be recruited, patients had to comply with the following
      criteria: symptoms suggestive of the common cold; age > or =2 months < or =2
      years; male and female. Patients presenting one or more of the following
      characteristics were not included: systemic diseases; congenital nasal
      obstruction (choanal atresia); infections of the upper and lower respiratory
      tracts other than common cold; systemic and/or topical use of antibiotics and/or 
      corticosteroids at the moment of recruitment. During the five months of the
      observation period, all the therapies that the investigators had decided it was
      necessary to administer had been included and recorded in the CRF. Patients
      evaluations were carried out for five months. The clinical assessment was
      performed at baseline (B), in the first week (Fw) and monthly and described as M1
      to 5; several clinical parameters were analyzed (anterior and posterior
      rhinorrhoea, oral respiration, noisy nasal respiration, and nasally transmitted
      thoracic sounds) and measured by the pediatrician at all examinations from B to
      M5. Other parameters were derived from the parents' daily observations, recorded 
      in a diary and made note of the quality of sleep, diet and respiration, and the
      use of any drug during any relapse of acute rhinitis (common cold episode).
      Recurrence of AOM and AR was assessed by the pediatrician at M1-2-3-4-5. Safety
      of use was determined using the Italian Health Ministry incident/near incident
      report sheets for Medical Device and based on diaries where the parents took note
      of any events which occurred during the observation period. Parental satisfaction
      and compliance were assessed through a questionnaire given to the parents at the 
      end of the last visit (M5). RESULTS: In the Narhinel group, the mean age was
      inferior (statistically significant): 8.9 compared to 11.4 months in the
      physiological saline solution group. The frequency of recurrences from viral
      rhinitis was very similar in the two groups and a decrease (statistical
      significant) was observed from M3 through M5 in both groups. Rhinorrhea, oral
      breathing, and other upper respiratory symptoms, improved in the two groups even 
      if in the Narhinel one the improvement was more prominent during the first two
      months of observation. There was no difference in the frequency of AR between the
      groups: at M4 and M5, there was a statistically significant decrease in the
      frequency of episodes. The frequency of AOM varied in the two groups considering 
      a comparison intra-groups: at M5 the decrease of episodes was statistically
      significant in the Narhinel group. In Narhinel group, AR and acute AOM seem to be
      more markedly controlled (frequency) especially for AOM. The frequency of adverse
      events (AEs) did not vary in the two groups: in the Narhinel one there was a
      difference (not statistically significant and not clinically relevant) in the
      number of patients with AEs, especially crying and nasal bleeding. One serious AE
      was reported in the physiological saline solution group. A 14-month-old child
      developed laryngospasm which recovered completely after hospital treatment with
      adrenaline. This event was not related to treatment with saline solution and
      causality was assessed as "unlikely" by the investigator. In the Narhinel group, 
      one serious event of moderate convulsion febrile in a male patient (age of 0.9)
      was reported. The causality relationship was assessed by the investigator as
      improbable. Parents' satisfaction was higher (statistically significant) in the
      Narhinel group compared to the physiological saline solution alone group.
      CONCLUSION: In acute rhinites (common cold) both medical devices are effective
      nevertheless Narhinel method is valid and shows better results in AOM and AR.
      Moreover Narhinel method was also more appreciated by parents than physiological 
      saline solution. According to authors' experience, the Narhinel method is safe
      and its performance is valid in the prevention of AOM and AR in children.
FAU - Montanari, G
AU  - Montanari G
AD  - FIMP Friuli Venezia Giulia, Pordenone, Italy.
FAU - Ceschin, F
AU  - Ceschin F
FAU - Masotti, S
AU  - Masotti S
FAU - Bravi, F
AU  - Bravi F
FAU - Chinea, B
AU  - Chinea B
FAU - Quartarone, G
AU  - Quartarone G
LA  - eng
LA  - ita
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Italy
TA  - Minerva Pediatr
JT  - Minerva pediatrica
JID - 0400740
RN  - 451W47IQ8X (Sodium Chloride)
SB  - IM
MH  - Acute Disease
MH  - Administration, Intranasal
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Otitis Media/*prevention & control/*virology
MH  - Prospective Studies
MH  - Recurrence
MH  - Respiratory Tract Infections/*prevention & control/*virology
MH  - Rhinitis/*prevention & control/*virology
MH  - Sinusitis/*prevention & control/*virology
MH  - Sodium Chloride/*administration & dosage
EDAT- 2010/03/10 06:00
MHDA- 2010/08/04 06:00
CRDT- 2010/03/10 06:00
PHST- 2010/03/10 06:00 [entrez]
PHST- 2010/03/10 06:00 [pubmed]
PHST- 2010/08/04 06:00 [medline]
AID - R15103503 [pii]
PST - ppublish
SO  - Minerva Pediatr. 2010 Feb;62(1):9-16, 17-21.


PMID- 20212064
OWN - NLM
STAT- MEDLINE
DCOM- 20110511
LR  - 20220129
IS  - 1461-7285 (Electronic)
IS  - 0269-8811 (Linking)
VI  - 25
IP  - 2
DP  - 2011 Feb
TI  - Neuroethical issues in cognitive enhancement.
PG  - 197-204
LID - 10.1177/0269881109106926 [doi]
AB  - Neuroethics is a developing field, concerned with addressing present and future
      applied ethical issues brought about directly and indirectly by neuroscience
      advancements. One domain where neuroscience has begun to have far-reaching
      ethical implications is in the research and development of pharmaceutical
      cognitive enhancers. Though such drugs are typically developed to treat cognitive
      disabilities and improve the quality of life for patients with neuropsychiatric
      disorders and brain injury, research has found that such drugs can improve
      performance on cognitive tasks in healthy individuals. In line with such findings
      is the growing use of these drugs by students and others for cognitive-enhancing 
      purposes. The present paper reviews some of the evidence in both neuropsychiatric
      and healthy individuals and discusses the implications such research can have for
      society.
FAU - Sahakian, Barbara J
AU  - Sahakian BJ
AD  - Department of Psychiatry, University of Cambridge School of Clinical Medicine,
      Addenbrooke's Hospital, Cambridge, UK.
FAU - Morein-Zamir, Sharon
AU  - Morein-Zamir S
LA  - eng
GR  - 086041/WT_/Wellcome Trust/United Kingdom
GR  - G0001354/MRC_/Medical Research Council/United Kingdom
GR  - 076274/Z/04/Z/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100308
PL  - United States
TA  - J Psychopharmacol
JT  - Journal of psychopharmacology (Oxford, England)
JID - 8907828
RN  - 0 (Nootropic Agents)
SB  - IM
MH  - *Bioethical Issues
MH  - Cognition/drug effects/*ethics
MH  - Cognition Disorders/*drug therapy
MH  - Humans
MH  - Neurosciences/*ethics
MH  - Nootropic Agents/*therapeutic use
MH  - Self Medication/ethics
EDAT- 2010/03/10 06:00
MHDA- 2011/05/12 06:00
CRDT- 2010/03/10 06:00
PHST- 2010/03/10 06:00 [entrez]
PHST- 2010/03/10 06:00 [pubmed]
PHST- 2011/05/12 06:00 [medline]
AID - 0269881109106926 [pii]
AID - 10.1177/0269881109106926 [doi]
PST - ppublish
SO  - J Psychopharmacol. 2011 Feb;25(2):197-204. doi: 10.1177/0269881109106926. Epub
      2010 Mar 8.


PMID- 20212001
OWN - NLM
STAT- MEDLINE
DCOM- 20100810
LR  - 20100309
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 3
DP  - 2010 Mar
TI  - Quality improvement in general practice: enabling general practitioners to judge 
      ethical dilemmas.
PG  - 184-8
LID - 10.1136/jme.2009.032078 [doi]
AB  - Quality improvement (QI) is fundamental to maintaining high standards of health
      care. Significant debate exists concerning the necessity for an ethical approval 
      system for those QI projects that push the boundaries, appearing more similar to 
      research than QI. The authors discuss this issue identifying the core ethical
      issues in family medicine (FM), drawing upon the fundamental principles of
      medical ethics, including principles of autonomy, utility, justice and
      non-maleficence. Recent debate concerning the application of QI ethics boards is 
      discussed with relevance to primary care and issues such as general practitioner 
      (GP) intentions, the impact of QI on patients and the use of confidential patient
      data and the impact of dissemination. The authors conclude that a system of QI
      ethical approval leaves many issues unresolved and potentially creates several
      barriers to implementing QI. To ensure ethical QI work is generated within FM it 
      is essential for GPs to learn about and engage in more ethical reflection so that
      they can better judge and resolve these issues.
FAU - Tapp, Laura
AU  - Tapp L
AD  - Department of Psychology, University of Southampton, Highfield Campus,
      Southampton SO17 1BJ, UK. l.tapp@soton.ac.uk
FAU - Edwards, Adrian
AU  - Edwards A
FAU - Elwyn, Glyn
AU  - Elwyn G
FAU - Holm, Soren
AU  - Holm S
FAU - Eriksson, Tina
AU  - Eriksson T
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Ethics, Medical
MH  - Family Practice/*ethics/standards
MH  - Health Policy
MH  - Humans
MH  - Physician-Patient Relations/*ethics
MH  - Physicians, Family/*ethics
MH  - Quality Assurance, Health Care/*ethics/organization & administration
MH  - Quality of Health Care/ethics/organization & administration
EDAT- 2010/03/10 06:00
MHDA- 2010/08/11 06:00
CRDT- 2010/03/10 06:00
PHST- 2010/03/10 06:00 [entrez]
PHST- 2010/03/10 06:00 [pubmed]
PHST- 2010/08/11 06:00 [medline]
AID - 36/3/184 [pii]
AID - 10.1136/jme.2009.032078 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Mar;36(3):184-8. doi: 10.1136/jme.2009.032078.


PMID- 20212000
OWN - NLM
STAT- MEDLINE
DCOM- 20100810
LR  - 20100309
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 3
DP  - 2010 Mar
TI  - Advance commitment: an alternative approach to the family veto problem in organ
      procurement.
PG  - 180-3
LID - 10.1136/jme.2009.032912 [doi]
AB  - This article tackles the current deficit in the supply of cadaveric organs by
      addressing the family veto in organ donation. The authors believe that the family
      veto matters-ethically as well as practically-and that policies that completely
      disregard the views of the family in this decision are likely to be
      counterproductive. Instead, this paper proposes to engage directly with the most 
      important reasons why families often object to the removal of the organs of a
      loved one who has signed up to the donor registry-notably a failure to understand
      fully and deliberate on the information and a reluctance to deal with this sort
      of decision at an emotionally distressing time. To accommodate these concerns it 
      is proposed to separate radically the process of information, deliberation and
      agreement about the harvesting of a potential donor's organs from the event of
      death and bereavement through a scheme of advance commitment. This paper briefly 
      sets out the proposal and discusses in some detail its design as well as what is 
      believed to be the main advantages compared with the leading alternatives.
FAU - De Wispelaere, Jurgen
AU  - De Wispelaere J
AD  - Centre de Recherche en Ethique, Universite de Montreal (CREUM), Montreal, Quebec,
      Canada. jurgen.dewispelaere@gmail.com
FAU - Stirton, Lindsay
AU  - Stirton L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Attitude to Death
MH  - Dissent and Disputes
MH  - Family/*psychology
MH  - Humans
MH  - Living Wills/*ethics/legislation & jurisprudence/psychology
MH  - Tissue Donors/*ethics/legislation & jurisprudence/psychology
MH  - Tissue and Organ Procurement/*ethics/legislation & jurisprudence/organization &
      administration
EDAT- 2010/03/10 06:00
MHDA- 2010/08/11 06:00
CRDT- 2010/03/10 06:00
PHST- 2010/03/10 06:00 [entrez]
PHST- 2010/03/10 06:00 [pubmed]
PHST- 2010/08/11 06:00 [medline]
AID - 36/3/180 [pii]
AID - 10.1136/jme.2009.032912 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Mar;36(3):180-3. doi: 10.1136/jme.2009.032912.


PMID- 20211997
OWN - NLM
STAT- MEDLINE
DCOM- 20100810
LR  - 20100309
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 3
DP  - 2010 Mar
TI  - Juridical and ethical peculiarities in doping policy.
PG  - 165-9
LID - 10.1136/jme.2009.030023 [doi]
AB  - Criticisms of the ethical justification of antidoping legislation are not
      uncommon in the literatures of medical ethics, sports ethics and sports medicine.
      Critics of antidoping point to inconsistencies of principle in the application of
      legislation and the unjustifiability of ethical postures enshrined in the World
      Anti-Doping Code, a new version of which came into effect in January 2009. This
      article explores the arguments concerning the apparent legal peculiarities of
      antidoping legislation and their ethically salient features in terms of: notions 
      of culpability, liability and guilt; aspects of potential duplication of
      punishments and the limitations of athlete privacy in antidoping practice and
      policy. It is noted that tensions still exist between legal and ethical
      principles and norms that require further critical attention.
FAU - McNamee, Mike J
AU  - McNamee MJ
AD  - Swansea University, University of Wales, Swansea, Singleton Park, Swansea SA2
      8PP, UK. m.j.mcnamee@swansea.ac.uk
FAU - Tarasti, Lauri
AU  - Tarasti L
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Doping in Sports/*ethics/*legislation & jurisprudence
MH  - *Ethics, Medical
MH  - Humans
MH  - International Cooperation/legislation & jurisprudence
MH  - Substance Abuse Detection/methods/psychology
EDAT- 2010/03/10 06:00
MHDA- 2010/08/11 06:00
CRDT- 2010/03/10 06:00
PHST- 2010/03/10 06:00 [entrez]
PHST- 2010/03/10 06:00 [pubmed]
PHST- 2010/08/11 06:00 [medline]
AID - 36/3/165 [pii]
AID - 10.1136/jme.2009.030023 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Mar;36(3):165-9. doi: 10.1136/jme.2009.030023.


PMID- 20211996
OWN - NLM
STAT- MEDLINE
DCOM- 20100810
LR  - 20100309
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 3
DP  - 2010 Mar
TI  - Dignity: not such a useless concept.
PG  - 160-4
LID - 10.1136/jme.2009.031393 [doi]
AB  - In her 2003 article in the British Medical Journal, Ruth Macklin provocatively
      declared dignity to be a useless concept: either a vague restatement of other
      more precise values, such as autonomy or respect for persons, or an empty slogan.
      A recent response to Macklin has challenged this claim. Doris Schroeder attempts 
      to rescue dignity by positing four distinct concepts that fall under the one
      umbrella term. She argues that much of the confusion surrounding dignity is due
      to the lack of disambiguation among these four concepts, but that once we
      understand the different values in question dignity becomes a powerful tool in
      the fields of human rights and bioethics. It is the goal of this paper to build
      upon Schroeder's insights by reconnecting the multiple strands of dignity she
      identifies. It will be argued that the usefulness of dignity as a guiding
      principle in medical ethics can be much improved by identifying the single
      conceptual link that ties together the various values flying under its banner.
      That conceptual link is provided by understanding dignity as the capacity to live
      by one's standards and principles.
FAU - Killmister, Suzy
AU  - Killmister S
AD  - Politics Department, School of People, Environment and Politics, Massey
      University, Palmerston North 4442, New Zealand. skillmister@massey.ac.nz
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Behavior
MH  - Humans
MH  - *Personhood
MH  - Social Values
EDAT- 2010/03/10 06:00
MHDA- 2010/08/11 06:00
CRDT- 2010/03/10 06:00
PHST- 2010/03/10 06:00 [entrez]
PHST- 2010/03/10 06:00 [pubmed]
PHST- 2010/08/11 06:00 [medline]
AID - 36/3/160 [pii]
AID - 10.1136/jme.2009.031393 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Mar;36(3):160-4. doi: 10.1136/jme.2009.031393.


PMID- 20211995
OWN - NLM
STAT- MEDLINE
DCOM- 20100810
LR  - 20100309
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 3
DP  - 2010 Mar
TI  - The cost of autonomy: estimates from recent advances in living donor kidney
      transplantation.
PG  - 155-9
LID - 10.1136/jme.2009.034306 [doi]
AB  - Autonomy, an individual's right to make personal decisions regarding his/her own 
      health, represents one of the major ethical principles of medicine. While there
      are many examples citing the benefits this right provides for the individual, the
      impact that personal healthcare decisions have on others is often neglected.
      Here, evidence from end-stage renal disease is reviewed to hypothesise the
      creation of a universal kidney donation programme that although provides
      unparalleled benefits to its citizens, relies on the participation of a large
      proportion of the society. Given that this essay also addresses the public's
      major concerns regarding kidney donation, one of the only remaining
      implementation barriers is the individuals' right not to participate. Therefore, 
      irrespective of the humane and complex emotionally laden reasons for not
      enrolling in such programmes, this essay provides some estimates of the
      significant resource and quality of life costs associated with autonomy. Assuming
      humans are competent to make informed personal healthcare choices, similar to
      recent efforts to increase awareness about the negative impact of certain
      lifestyle choices on global warming, citizens should also be better informed
      about the medical costs their autonomy has on society.
FAU - Diamandis, Phedias
AU  - Diamandis P
AD  - Program in Developmental and Stem Cell Biology, The Hospital for Sick Children
      and University of Toronto, Canada. p.diamandis@utoronto.ca
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Humans
MH  - Informed Consent/psychology
MH  - Kidney Failure, Chronic/therapy
MH  - Kidney Transplantation/*psychology
MH  - Living Donors/*psychology
MH  - Patient Rights/ethics
MH  - *Personal Autonomy
MH  - *Program Development
MH  - Tissue and Organ Procurement/*organization & administration/standards
EDAT- 2010/03/10 06:00
MHDA- 2010/08/11 06:00
CRDT- 2010/03/10 06:00
PHST- 2010/03/10 06:00 [entrez]
PHST- 2010/03/10 06:00 [pubmed]
PHST- 2010/08/11 06:00 [medline]
AID - 36/3/155 [pii]
AID - 10.1136/jme.2009.034306 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Mar;36(3):155-9. doi: 10.1136/jme.2009.034306.


PMID- 20211994
OWN - NLM
STAT- MEDLINE
DCOM- 20100810
LR  - 20201209
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 3
DP  - 2010 Mar
TI  - Sex rights for the disabled?
PG  - 152-4
LID - 10.1136/jme.2009.033183 [doi]
AB  - The public discourse surrounding sex and severe disability over the past 40 years
      has largely focused on protecting vulnerable populations from abuse. However,
      health professionals and activists are increasingly recognising the inherent
      sexuality of disabled persons and attempting to find ways to accommodate their
      intimacy needs. This essay explores several ethical issues arising from such
      efforts.
FAU - Appel, Jacob M
AU  - Appel JM
AD  - Department of Psychiatry, Mount Sinai Hospital, New York City, New York, USA.
      jacobmappel@gmail.com
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
CIN - J Med Ethics. 2011 Mar;37(3):158-61. PMID: 21059634
CIN - J Med Ethics. 2018 Apr;44(4):253-256. PMID: 29101302
MH  - Attitude of Health Personnel
MH  - Bioethical Issues
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Human Rights
MH  - Humans
MH  - Male
MH  - Persons with Mental Disabilities/*psychology
MH  - Pleasure
MH  - Sex Work
MH  - Sexual Behavior/*psychology
EDAT- 2010/03/10 06:00
MHDA- 2010/08/11 06:00
CRDT- 2010/03/10 06:00
PHST- 2010/03/10 06:00 [entrez]
PHST- 2010/03/10 06:00 [pubmed]
PHST- 2010/08/11 06:00 [medline]
AID - 36/3/152 [pii]
AID - 10.1136/jme.2009.033183 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Mar;36(3):152-4. doi: 10.1136/jme.2009.033183.


PMID- 20211991
OWN - NLM
STAT- MEDLINE
DCOM- 20100810
LR  - 20151119
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 3
DP  - 2010 Mar
TI  - The ethics of basing community prevention in general practice.
PG  - 138-41
LID - 10.1136/jme.2009.032284 [doi]
AB  - In this paper we argue that the responsibility for systematic community-based
      preventive medicine should not be made part of the role of the general
      practitioner (GP). Preventive medicine cannot be shown to be more effective than 
      curative or supportive medicine. Therefore, the allocation of the large amount of
      general practice staff time and resources required for systematic preventive
      medicine should not come at the expense of the care of the sick and the
      suffering. The traditional healing role of the GP requires a cooperative
      patient-centred approach, whereas systematic preventive medicine is driven by
      rigid pre-set protocols and is intrinsically paternalistic. Trying to merge the
      two approaches is detrimental to the doctor-patient relationship. Furthermore, a 
      number of potential pitfalls are identified that may be encountered in the
      implementation of preventive medicine programmes in general practice:
      interference with the course of the consultation; inadequate explanation and
      consent; distortion of practice priorities as reflected in quality indicators;
      temptation to record inaccurate data; conflict of interests where the doctor is
      rewarded for performance; patient blaming; exacerbation of the health gap. We
      suggest that a more justifiable strategy would be for GPs to identify patients at
      high risk and offer them specific preventive advice when the opportunity presents
      itself and at a time when the patient is likely to be most amenable to cooperate.
      Opportunistic health promotion offers higher expectations of benefit, as well as 
      a more equitable allocation of the risks associated with preventive medicine,
      than a systematic community-based approach.
FAU - Weingarten, Michael
AU  - Weingarten M
AD  - Department of Family Medicine, Rabin Medical Centre-Beilinson Campus, Petah
      Tikva, Israel. weingml@post.tau.ac.il
FAU - Matalon, Andre
AU  - Matalon A
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Attitude of Health Personnel
MH  - Community Health Services/*organization & administration
MH  - Family Practice/*organization & administration
MH  - Health Promotion/*organization & administration
MH  - Humans
MH  - Practice Patterns, Physicians'/*organization & administration
MH  - Preventive Medicine/*organization & administration
EDAT- 2010/03/10 06:00
MHDA- 2010/08/11 06:00
CRDT- 2010/03/10 06:00
PHST- 2010/03/10 06:00 [entrez]
PHST- 2010/03/10 06:00 [pubmed]
PHST- 2010/08/11 06:00 [medline]
AID - 36/3/138 [pii]
AID - 10.1136/jme.2009.032284 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Mar;36(3):138-41. doi: 10.1136/jme.2009.032284.


PMID- 20211990
OWN - NLM
STAT- MEDLINE
DCOM- 20100810
LR  - 20151119
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 3
DP  - 2010 Mar
TI  - Evolution of hospital clinical ethics committees in Canada.
PG  - 132-7
LID - 10.1136/jme.2009.032607 [doi]
AB  - To investigate the current status of hospital clinical ethics committees (CEC)
      and how they have evolved in Canada over the past 20 years, this paper presents
      an overview of the findings from a 2008 survey and compares these findings with
      two previous Canadian surveys conducted in 1989 and 1984. All Canadian hospitals 
      over 100 beds, of which at least some were acute care, were surveyed to determine
      the structure of CEC, how they function, the perceived achievements of these
      committees and opinions about areas with which CEC should be involved. The
      percentage of hospitals with CEC in our sample was found to be 85% compared with 
      58% and 18% in 1989 and 1984, respectively. The wide variation in the size of
      committees and the composition of their membership has continued. Meetings of CEC
      have become more regularised and formalised over time. CEC continue to be
      predominately advisory in their nature, and by 2008 there was a shift in the
      priority of the activities of CEC to meeting ethics education needs and providing
      counselling and support with less emphasis on advising about policy and
      procedures. More research is needed on how best to define what the scope of
      activities of CEC should be in order to meet the needs of hospitals in Canada and
      elsewhere. More research also is needed on the actual outcomes to patients,
      families, health professionals and organisations from the work of these
      committees in order to support the considerable time committee members devote to 
      this endeavour.
FAU - Gaudine, Alice
AU  - Gaudine A
AD  - School of Nursing, Memorial University of Newfoundland, St John's NL A1B 3V6,
      Canada.
FAU - Thorne, Linda
AU  - Thorne L
FAU - LeFort, Sandra M
AU  - LeFort SM
FAU - Lamb, Marianne
AU  - Lamb M
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Attitude of Health Personnel
MH  - Canada
MH  - Committee Membership
MH  - Ethics Committees, Clinical/*organization & administration/trends
MH  - Hospital Administration/*trends
MH  - Hospital Bed Capacity
MH  - Humans
MH  - Surveys and Questionnaires
EDAT- 2010/03/10 06:00
MHDA- 2010/08/11 06:00
CRDT- 2010/03/10 06:00
PHST- 2010/03/10 06:00 [entrez]
PHST- 2010/03/10 06:00 [pubmed]
PHST- 2010/08/11 06:00 [medline]
AID - 36/3/132 [pii]
AID - 10.1136/jme.2009.032607 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Mar;36(3):132-7. doi: 10.1136/jme.2009.032607.


PMID- 20211615
OWN - NLM
STAT- MEDLINE
DCOM- 20100901
LR  - 20181201
IS  - 1872-7786 (Electronic)
IS  - 0009-2797 (Linking)
VI  - 187
IP  - 1-3
DP  - 2010 Sep 6
TI  - Demonstration of in vivo stability and lack of immunogenicity of a
      polyethyleneglycol-conjugated recombinant CHO-derived butyrylcholinesterase
      bioscavenger using a homologous macaque model.
PG  - 279-86
LID - 10.1016/j.cbi.2010.02.042 [doi]
AB  - Human serum and recombinant butyrylcholinesterase (rHuBChE) are the most advanced
      prophylactics against organophosphate (OP) toxicity due to nerve agent or
      insecticide exposure. For ethical reasons, such potential multi-use treatments
      cannot be tested in humans and will require extensive testing in animal models
      and the "Animal Rule" 21 (21 CFR 601.90) for regulatory approval. This will
      involve multiple injections of rHuBChE into heterologous animals, e.g. macaques, 
      rodents with inevitable immunogenicity and subsequent elimination of the enzyme
      on repeat injections. In order to accurately assess pharmacokinetics, efficacy
      and safety of a candidate rBChE in an "antibody free" system, a homologous
      macaque (Ma) model has been developed. In these studies, macaques received single
      or multiple intravenous injections of native MaBChE as well as unmodified or
      PEG-conjugated forms of rMaBChE produced in CHO cells. Compared to the poor
      plasma retention of unmodified rBChE (MRT: <10h), three injections of
      1.5-2.3mg/kg of PEG-conjugated tetrameric rBChE resulted in high circulatory
      stability (MRT: >134h) and lack of immunogenicity similar to native MaBChE.
      PEG-conjugation of the monomeric rMaBChE form also exhibited pharmacokinetic
      profiles comparable to the tetrameric form (MRT: >113h). However, despite the
      increased bioavailability of PEG-rBChE, antigenicity studies using sandwich ELISA
      showed that while macaque BChE was not immunogenic in macaques, PEGylation of
      rMaBChE did not prevent binding to anti-BChE antibodies, suggesting PEGylation
      may not be sufficient to mask non-human epitopes on rBChE. This homologous model 
      can provide necessary preclinical protection data for the use of PEG-rHuBChE in
      humans and bodes well for a safe and efficacious CHO-derived rHuBChE therapeutic.
CI  - Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Rosenberg, Yvonne J
AU  - Rosenberg YJ
AD  - PlantVax Inc., Suite 120, 9430 Key West Avenue, Rockville, MD 20850-6350, USA.
      yjr@plantvax.com
FAU - Saxena, Ashima
AU  - Saxena A
FAU - Sun, Wei
AU  - Sun W
FAU - Jiang, Xiaoming
AU  - Jiang X
FAU - Chilukuri, Nageswararao
AU  - Chilukuri N
FAU - Luo, Chunjuan
AU  - Luo C
FAU - Doctor, Bhupendra P
AU  - Doctor BP
FAU - Lee, Keunmyoung D
AU  - Lee KD
LA  - eng
GR  - R44 NS064608/NS/NINDS NIH HHS/United States
PT  - Journal Article
DEP - 20100306
PL  - Ireland
TA  - Chem Biol Interact
JT  - Chemico-biological interactions
JID - 0227276
RN  - 0 (Antibodies)
RN  - 0 (Antidotes)
RN  - 0 (Organophosphorus Compounds)
RN  - 0 (Recombinant Proteins)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - EC 3.1.1.8 (Butyrylcholinesterase)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Antibodies/immunology
MH  - Antidotes/chemistry/metabolism/pharmacokinetics
MH  - Butyrylcholinesterase/*chemistry/immunology/*metabolism/pharmacokinetics
MH  - CHO Cells
MH  - Catalytic Domain
MH  - Cloning, Molecular
MH  - Cricetinae
MH  - Cricetulus
MH  - Drug Discovery
MH  - Enzyme Stability
MH  - Humans
MH  - Injections
MH  - *Macaca
MH  - Mice
MH  - Models, Animal
MH  - Molecular Sequence Data
MH  - Organophosphorus Compounds/metabolism/toxicity
MH  - Polyethylene Glycols/*chemistry
MH  - Protein Multimerization
MH  - Protein Structure, Quaternary
MH  - Recombinant Proteins/*chemistry/immunology/*metabolism/pharmacokinetics
MH  - *Sequence Homology, Amino Acid
EDAT- 2010/03/10 06:00
MHDA- 2010/09/02 06:00
CRDT- 2010/03/10 06:00
PHST- 2009/12/01 00:00 [received]
PHST- 2010/02/23 00:00 [revised]
PHST- 2010/02/24 00:00 [accepted]
PHST- 2010/03/10 06:00 [entrez]
PHST- 2010/03/10 06:00 [pubmed]
PHST- 2010/09/02 06:00 [medline]
AID - S0009-2797(10)00110-9 [pii]
AID - 10.1016/j.cbi.2010.02.042 [doi]
PST - ppublish
SO  - Chem Biol Interact. 2010 Sep 6;187(1-3):279-86. doi: 10.1016/j.cbi.2010.02.042.
      Epub 2010 Mar 6.


PMID- 20211411
OWN - NLM
STAT- MEDLINE
DCOM- 20100702
LR  - 20200401
IS  - 1527-2966 (Electronic)
IS  - 0099-1767 (Linking)
VI  - 36
IP  - 2
DP  - 2010 Mar
TI  - International nurses: pending policy for reform and ethical recruitment.
PG  - 159-61
LID - 10.1016/j.jen.2009.12.010 [doi]
FAU - Hellquist, Kristin A
AU  - Hellquist KA
AD  - KAR Associates, Falls Church, VA 22042, USA. khellquist@aol.com
LA  - eng
PT  - Journal Article
DEP - 20091229
PL  - United States
TA  - J Emerg Nurs
JT  - Journal of emergency nursing
JID - 7605913
MH  - Foreign Professional Personnel/*standards
MH  - Humans
MH  - Nursing Staff, Hospital/*supply & distribution
MH  - Personnel Selection/*ethics/*standards
MH  - United States
EDAT- 2010/03/10 06:00
MHDA- 2010/07/03 06:00
CRDT- 2010/03/10 06:00
PHST- 2010/03/10 06:00 [entrez]
PHST- 2010/03/10 06:00 [pubmed]
PHST- 2010/07/03 06:00 [medline]
AID - S0099-1767(09)00564-9 [pii]
AID - 10.1016/j.jen.2009.12.010 [doi]
PST - ppublish
SO  - J Emerg Nurs. 2010 Mar;36(2):159-61. doi: 10.1016/j.jen.2009.12.010. Epub 2009
      Dec 29.


PMID- 20211088
OWN - NLM
STAT- MEDLINE
DCOM- 20100427
LR  - 20100309
IS  - 1603-6824 (Electronic)
IS  - 0041-5782 (Linking)
VI  - 172
IP  - 10
DP  - 2010 Mar 8
TI  - [Prevention in health care--opportunities and limitations].
PG  - 798-800
AB  - Disease prevention and health promotion performed by the health care sector may
      in general be characterised as adhering to a high-risk strategy, in which
      individuals with an elevated risk of falling ill or dying are identified and
      encouraged to change their behaviour and sometimes take preventive drugs. The
      approach thus has great similarities and fits well with the other activities in
      health care. Prevention in the health care sector rarely prevents people from
      ending up in high risk groups. Interventions therefore become never-ending
      stories. Public health ethics may turn out as an important future research field.
FAU - Vallgarda, Signild
AU  - Vallgarda S
AD  - Institut for Folkesundhedsvidenskab, Afdeling for Sundhedstjenesteforskning,
      Kobenhavns Universitet, Oster Farimagsgade 5, DK-1014 Kobenhavn, Denmark.
      s.vallgarda@pubhealth.ku.dk
LA  - dan
PT  - English Abstract
PT  - Journal Article
TT  - Forebyggelse i sundhedsvaesenet--muligheder og begraensninger.
PL  - Denmark
TA  - Ugeskr Laeger
JT  - Ugeskrift for laeger
JID - 0141730
SB  - IM
MH  - Denmark
MH  - Health Policy
MH  - *Health Promotion
MH  - Health Services Research
MH  - Humans
MH  - *Preventive Health Services
MH  - *Public Health
MH  - Risk Factors
EDAT- 2010/03/10 06:00
MHDA- 2010/04/28 06:00
CRDT- 2010/03/10 06:00
PHST- 2010/03/10 06:00 [entrez]
PHST- 2010/03/10 06:00 [pubmed]
PHST- 2010/04/28 06:00 [medline]
AID - VP10090476 [pii]
PST - ppublish
SO  - Ugeskr Laeger. 2010 Mar 8;172(10):798-800.


PMID- 20211030
OWN - NLM
STAT- MEDLINE
DCOM- 20100413
LR  - 20181113
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 11
DP  - 2010 Mar 9
TI  - Convergent ethical issues in HIV/AIDS, tuberculosis and malaria vaccine trials in
      Africa: Report from the WHO/UNAIDS African AIDS Vaccine Programme's Ethics, Law
      and Human Rights Collaborating Centre consultation, 10-11 February 2009, Durban, 
      South Africa.
PG  - 3
LID - 10.1186/1472-6939-11-3 [doi]
AB  - BACKGROUND: Africa continues to bear a disproportionate share of the global
      HIV/AIDS, tuberculosis (TB) and malaria burden. The development and distribution 
      of safe, effective and affordable vaccines is critical to reduce these epidemics.
      However, conducting HIV/AIDS, TB, and/or malaria vaccine trials simultaneously in
      developing countries, or in populations affected by all three diseases, is likely
      to result in numerous ethical challenges. METHODS: In order to explore convergent
      ethical issues in HIV/AIDS, TB and malaria vaccine trials in Africa, the Ethics, 
      Law and Human Rights Collaborating Centre of the WHO/UNAIDS African AIDS Vaccine 
      Programme hosted a consultation on the Convergent Ethical Issues in HIV/AIDS, TB 
      and Malaria Vaccine Trials in Africa in Durban, South Africa on the 10-11
      February 2009. RESULTS: Key cross cutting ethical issues were prioritized during 
      the consultation as community engagement; ancillary care obligations; care and
      treatment; informed consent; and resource sharing. CONCLUSION: The consultation
      revealed that while there have been few attempts to find convergence on ethical
      issues between HIV/AIDS, TB and malaria vaccine trial fields to date, there is
      much common ground and scope for convergence work between stakeholders in the
      three fields.
FAU - Mamotte, Nicole
AU  - Mamotte N
AD  - African AIDS Vaccine Programme's Ethics, Law and Human Rights Collaborating
      Center, School of Psychology, University of KwaZulu-Natal, Pietermaritzburg,
      South Africa. mamotten@ukzn.ac.za
FAU - Wassenaar, Douglas
AU  - Wassenaar D
FAU - Koen, Jennifer
AU  - Koen J
FAU - Essack, Zaynab
AU  - Essack Z
LA  - eng
PT  - Journal Article
DEP - 20100309
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
RN  - 0 (AIDS Vaccines)
RN  - 0 (Malaria Vaccines)
RN  - 0 (Tuberculosis Vaccines)
SB  - IM
MH  - *AIDS Vaccines
MH  - Adolescent
MH  - Adult
MH  - Africa/epidemiology
MH  - Aged
MH  - Bioethical Issues
MH  - Clinical Trials as Topic/*ethics
MH  - *Ethics Consultation
MH  - Ethics, Research
MH  - Female
MH  - HIV Infections/epidemiology/prevention & control
MH  - Humans
MH  - *Immunization Programs/ethics/legislation & jurisprudence/standards/trends
MH  - Informed Consent/*ethics
MH  - International Cooperation
MH  - Malaria/epidemiology/prevention & control
MH  - *Malaria Vaccines
MH  - Male
MH  - Middle Aged
MH  - Tuberculosis/epidemiology/prevention & control
MH  - *Tuberculosis Vaccines
MH  - Young Adult
PMC - PMC2845591
EDAT- 2010/03/10 06:00
MHDA- 2010/04/14 06:00
CRDT- 2010/03/10 06:00
PHST- 2009/10/28 00:00 [received]
PHST- 2010/03/09 00:00 [accepted]
PHST- 2010/03/10 06:00 [entrez]
PHST- 2010/03/10 06:00 [pubmed]
PHST- 2010/04/14 06:00 [medline]
AID - 1472-6939-11-3 [pii]
AID - 10.1186/1472-6939-11-3 [doi]
PST - epublish
SO  - BMC Med Ethics. 2010 Mar 9;11:3. doi: 10.1186/1472-6939-11-3.


PMID- 20209689
OWN - NLM
STAT- MEDLINE
DCOM- 20100401
LR  - 20100308
IS  - 0030-9982 (Print)
IS  - 0030-9982 (Linking)
VI  - 60
IP  - 2
DP  - 2010 Feb
TI  - Father's support and literacy--factors associated with child mortality in Gambat,
      Sindh-Pakistan.
PG  - 81-5
AB  - OBJECTIVES: To determine Under Five Mortality Rate (U5MR) in Gambat and to
      identify causes of and factors associated with it. METHODS: The study was
      conducted in taluka Gambat of Sindh, Pakistan from December 2002 to August 2003. 
      The sample of at least 510 mothers was needed to capture expected 1020 live
      births. We interviewed mothers to elicit information about live births in the
      past five years, under-five mortality and its cause. Additionally, the mothers
      were also asked about their mobility and availability of husband's support in
      child's rearing, other than economic support. Approval was sought from Aga Khan
      University's Ethical Committee. Pre structured questionnaire was used. Data were 
      double entered, validated and cleaned using Epi-Info 6 and analysed with
      Statistical Package for Social Sciences (SPSS) version 11.5. RESULTS: We included
      647 mothers, who reported 997 births in the past five years. The reported number 
      of deaths was 169, with the estimated U5MR of 170/1000 live births/year. The five
      major causes of mortality were tetanus (17.8%), diarrhoea (11.8%), measles
      (6.5%), delivery related morbidities (6.5%) and Acute Respiratory Infections
      (4.5%). Fever was identified as a cause by 19.1% mothers. About 20% did not know 
      the cause of death. The regression analysis showed father's literacy level (AOR
      1.8, 95% CI 1.1-2.8) and father's support in child rearing (AOR 5.6, 95% CI
      3.6-8.6) as factors significantly associated with mortality. CONCLUSION:
      Increasing education among parents in rural areas like Gambat is important to
      reduce child mortality. Father's involvement in child rearing can play a role.
FAU - Agha, Ajmal
AU  - Agha A
AD  - Department of Community Health Sciences, Aga Khan University.
FAU - Ajmal, Fozia
AU  - Ajmal F
FAU - Iqbal, Azam
AU  - Iqbal A
FAU - White, Franklin
AU  - White F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Pakistan
TA  - J Pak Med Assoc
JT  - JPMA. The Journal of the Pakistan Medical Association
JID - 7501162
SB  - IM
EIN - J Pak Med Assoc. 2010 Mar;60(3):248
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - *Child Mortality
MH  - *Child Rearing
MH  - *Educational Status
MH  - *Fathers
MH  - Female
MH  - Humans
MH  - Male
MH  - Pakistan/epidemiology
MH  - Young Adult
EDAT- 2010/03/10 06:00
MHDA- 2010/04/02 06:00
CRDT- 2010/03/10 06:00
PHST- 2010/03/10 06:00 [entrez]
PHST- 2010/03/10 06:00 [pubmed]
PHST- 2010/04/02 06:00 [medline]
AID - 1914 [pii]
PST - ppublish
SO  - J Pak Med Assoc. 2010 Feb;60(2):81-5.


PMID- 20185956
OWN - NLM
STAT- MEDLINE
DCOM- 20100610
LR  - 20110217
IS  - 1423-0275 (Electronic)
IS  - 0301-1569 (Linking)
VI  - 71 Suppl 1
DP  - 2010
TI  - Computer simulation of antidromic facial nerve response waveform.
PG  - 91-8
LID - 10.1159/000265115 [doi]
AB  - CONCLUSION: An assessment of facial nerve (FN) damage on the basis of antidromic 
      facial nerve response (AFNR) was established by computer simulation analysis.
      Computer simulation has the advantage of being able to assume any type of lesion.
      In the near future, computer analysis should provide another experimental method 
      which displaces animal experiments, thus circumventing the ethical dilemma
      associated with animal experiments. BACKGROUND: AFNR is a promising method to
      monitor intratemporal FN lesions. Clinical application of AFNR showed that
      waveform changes reflected the site and degree of the lesion. However, the
      association between the waveform changes and pathologic conditions of FN remains 
      to be clarified. OBJECTIVE: To analyze the association between waveform changes
      and the degree and site of nerve degeneration or blockade with the use of
      computer simulation, and to speculate the degree and involvement of the
      intratemporal FN lesions underlying the changes of AFNR waveforms. METHODS: AFNR 
      waveform, latency and amplitude changes in various types of nerve conduction
      block in the intratemporal FN were analyzed with the use of a computer simulation
      program based on the solid-angle approximation theory. RESULT: The present
      computer simulation revealed a temporal increase in the peak-to-peak amplitude
      between 1st and 2nd waves, when the nerve blockade extends 1 mm distally from the
      recording site. Generally, AFNR in severe palsy cases gradually decreases in
      amplitude as the waveform change from biphasic to monophasic, ultimately falling 
      into non-response. According to the computer simulation, the decay of AFNR
      reflects conduction blocking in 63% or more of FN fibers. The amplitude ratio of 
      the first positive/negative wave was indicative of the site of the lesion in
      relation to the recording site. The ratios were <0.586 when the lesions were
      situated >1 mm proximal and they were >0.667 when the lesions were peripheral to 
      the recording site.
FAU - Iwai, Mitsuru
AU  - Iwai M
AD  - Department of Otolaryngology, Kochi Medical School, Nankoku, Kochi, Japan.
FAU - Takeda, Taizo
AU  - Takeda T
FAU - Nakatani, Hiroaki
AU  - Nakatani H
FAU - Kakigi, Akinobu
AU  - Kakigi A
LA  - eng
PT  - Journal Article
DEP - 20100224
PL  - Switzerland
TA  - ORL J Otorhinolaryngol Relat Spec
JT  - ORL; journal for oto-rhino-laryngology and its related specialties
JID - 0334721
SB  - IM
MH  - *Computer Simulation
MH  - Facial Nerve/*physiopathology
MH  - Facial Paralysis/*physiopathology
MH  - Humans
MH  - Nerve Block
MH  - Neural Conduction/physiology
MH  - *Signal Processing, Computer-Assisted
EDAT- 2010/03/10 06:00
MHDA- 2010/06/11 06:00
CRDT- 2010/02/27 06:00
PHST- 2010/02/27 06:00 [entrez]
PHST- 2010/03/10 06:00 [pubmed]
PHST- 2010/06/11 06:00 [medline]
AID - 000265115 [pii]
AID - 10.1159/000265115 [doi]
PST - ppublish
SO  - ORL J Otorhinolaryngol Relat Spec. 2010;71 Suppl 1:91-8. doi: 10.1159/000265115. 
      Epub 2010 Feb 24.


PMID- 20209478
OWN - NLM
STAT- MEDLINE
DCOM- 20100810
LR  - 20131121
IS  - 1097-0258 (Electronic)
IS  - 0277-6715 (Linking)
VI  - 29
IP  - 10
DP  - 2010 May 10
TI  - Estimating long-term effects of treatment from placebo-controlled trials with an 
      extension period, using virtual twins.
PG  - 1127-36
LID - 10.1002/sim.3870 [doi]
AB  - The best information about the benefits of long-term treatment is obtained from a
      long-term placebo-controlled trial. However, once efficacy has been demonstrated 
      in relatively brief trials, it may not be possible to conduct long-term
      placebo-controlled trials, for ethical or practical reasons. This paper presents 
      a method for estimating long-term effects of a treatment from a
      placebo-controlled trial in which some participants originally randomized to
      active-treatment volunteer to continue on treatment during an extension study,
      but follow-up of participants originally assigned to placebo ends with the trial,
      or they are crossed over to active treatment during the extension. We propose
      using data from the trial to project the outcomes for a 'virtual twin' for each
      active-treatment volunteer under the counterfactual placebo condition, and using 
      bootstrap methods for inference. The proposed method is validated using
      simulation, and applied to data from the Fracture Intervention Trial and its
      extension, FLEX.
FAU - Vittinghoff, Eric
AU  - Vittinghoff E
AD  - Department of Epidemiology and Biostatistics, University of California San
      Francisco, San Francisco, CA 94107, USA. eric@biostat.ucsf.edu
FAU - McCulloch, Charles E
AU  - McCulloch CE
FAU - Woo, Claudine
AU  - Woo C
FAU - Cummings, Steven R
AU  - Cummings SR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Stat Med
JT  - Statistics in medicine
JID - 8215016
RN  - 0 (Bone Density Conservation Agents)
RN  - 0 (Placebos)
RN  - X1J18R4W8P (Alendronate)
SB  - IM
MH  - Alendronate/therapeutic use
MH  - Bone Density Conservation Agents/therapeutic use
MH  - Computer Simulation
MH  - Humans
MH  - *Models, Statistical
MH  - Monte Carlo Method
MH  - Osteoporosis, Postmenopausal/drug therapy
MH  - *Placebos
MH  - Poisson Distribution
MH  - Randomized Controlled Trials as Topic/*methods
EDAT- 2010/03/09 06:00
MHDA- 2010/08/11 06:00
CRDT- 2010/03/09 06:00
PHST- 2010/03/09 06:00 [entrez]
PHST- 2010/03/09 06:00 [pubmed]
PHST- 2010/08/11 06:00 [medline]
AID - 10.1002/sim.3870 [doi]
PST - ppublish
SO  - Stat Med. 2010 May 10;29(10):1127-36. doi: 10.1002/sim.3870.


PMID- 20209388
OWN - NLM
STAT- MEDLINE
DCOM- 20100330
LR  - 20100308
IS  - 1306-696X (Print)
VI  - 16
IP  - 1
DP  - 2010 Jan
TI  - [Informed consent in emergency medicine].
PG  - 1-8
AB  - Informed consent is a prerequisite for the ethical and legal validity of the
      emergency intervention in emergency medicine, since it protects the fiduciary
      relationship between the physician and patient; the principle of honesty that
      grounds this relationship; the principle of autonomy that necessitates right of
      self-determination; and the principle of respect for persons. Informed consent in
      emergency medicine, which is supposed to include the nature, benefits and risks
      of emergency medical intervention, differentiates with respect to definite groups
      of patients: (1) conscious patients, (2) unconscious patients, and (3) children
      and mature minors. In addition, informed consent differentiates between medical, 
      psychological and even social circumstances of the patients, referred to as valid
      consent, expressed-explicit consent, blanket consent, presumed consent, tacit
      consent, proxy consent, and parental consent. There are a few exceptions in which
      emergency medical intervention is administered without informed consent. In
      addition to the exceptions of life-saving interventions, when a patient can not
      decide for herself/himself, intervention of the physician in the best interest of
      the patient or children is based on the "therapeutic privilege" of the physician.
      As an ethically defensible right, since therapeutic privilege may open a door to 
      hard paternalistic approaches, in those situations, emergency physicians should
      be cautious not to violate a patient's autonomy.
FAU - Ersoy, Nermin
AU  - Ersoy N
AD  - Department of Medical History and Ethics, Kocaeli University Faculty of Medicine,
      Kocaeli, Turkey. n.ersoy@yahoo.com.tr
FAU - Ozcan Senses, Muesser
AU  - Ozcan Senses M
FAU - Aydin Er, Rahime
AU  - Aydin Er R
LA  - tur
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Acil tip'ta aydinlatilmis onam.
PL  - Turkey
TA  - Ulus Travma Acil Cerrahi Derg
JT  - Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency
      surgery : TJTES
JID - 101274231
SB  - IM
MH  - Consciousness
MH  - Emergency Medical Services/*ethics/legislation & jurisprudence
MH  - Humans
MH  - *Informed Consent
MH  - *Mental Competency
MH  - Parental Consent
MH  - Patient Rights
MH  - Personal Autonomy
MH  - *Presumed Consent
MH  - Proxy
MH  - Third-Party Consent
RF  - 45
EDAT- 2010/03/09 06:00
MHDA- 2010/03/31 06:00
CRDT- 2010/03/09 06:00
PHST- 2010/03/09 06:00 [entrez]
PHST- 2010/03/09 06:00 [pubmed]
PHST- 2010/03/31 06:00 [medline]
PST - ppublish
SO  - Ulus Travma Acil Cerrahi Derg. 2010 Jan;16(1):1-8.


PMID- 20208074
OWN - NLM
STAT- MEDLINE
DCOM- 20101103
LR  - 20151119
IS  - 1460-2385 (Electronic)
IS  - 0931-0509 (Linking)
VI  - 25
IP  - 7
DP  - 2010 Jul
TI  - Patient and health professional preferences for organ allocation and procurement,
      end-of-life care and organization of care for patients with chronic kidney
      disease using a discrete choice experiment.
PG  - 2334-41
LID - 10.1093/ndt/gfq072 [doi]
AB  - BACKGROUND: Clinical practice, policy and research, and the ethical bases upon
      which they are founded, should be systematically and transparently informed by
      both patient and professional values. METHODS: A discrete choice experiment was
      utilized to understand and quantify the preferences of 351 Canadian patients and 
      healthcare providers in relation to ethically challenging aspects of the
      management of chronic kidney disease (CKD): procurement and allocation of organs 
      for transplantation, end-of-life care discussions and decision making and the
      identities of those providing primary care. RESULTS: Patients and health
      professionals had clear preferences for detailed prognostic information, early
      advance care planning, shared end-of-life decision making, coordinated models of 
      care that enhance interaction and communication between primary and tertiary care
      and a more utilitarian approach of best match over first come, first served for
      allocating deceased donor kidneys. These data also suggest that the innovative
      strategies of non-directed anonymous donation and paired kidney exchange that are
      slowly being implemented internationally will be acceptable to both patients and 
      healthcare providers. CONCLUSIONS: Current models of CKD care do not consistently
      reflect the preferences or priorities of either health professionals or patients.
FAU - Davison, Sara N
AU  - Davison SN
AD  - Department of Medicine, University of Alberta, 11-107 Clinical Sciences Building,
      Edmonton Alberta T6G2G3. sara.davison@ualberta.ca
FAU - Kromm, Seija K
AU  - Kromm SK
FAU - Currie, Gillian R
AU  - Currie GR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100305
PL  - England
TA  - Nephrol Dial Transplant
JT  - Nephrology, dialysis, transplantation : official publication of the European
      Dialysis and Transplant Association - European Renal Association
JID - 8706402
SB  - IM
MH  - Adult
MH  - Advance Directives/*ethics
MH  - Aged
MH  - Canada
MH  - Choice Behavior
MH  - Chronic Disease
MH  - Decision Support Techniques
MH  - Female
MH  - *Health Care Surveys
MH  - Health Personnel/*psychology
MH  - Humans
MH  - Kidney Diseases/*therapy
MH  - Male
MH  - Middle Aged
MH  - Patient Care Management/*ethics
MH  - Patient Preference/*psychology
MH  - Surveys and Questionnaires
MH  - Tissue and Organ Procurement/*ethics
EDAT- 2010/03/09 06:00
MHDA- 2010/11/04 06:00
CRDT- 2010/03/09 06:00
PHST- 2010/03/09 06:00 [entrez]
PHST- 2010/03/09 06:00 [pubmed]
PHST- 2010/11/04 06:00 [medline]
AID - gfq072 [pii]
AID - 10.1093/ndt/gfq072 [doi]
PST - ppublish
SO  - Nephrol Dial Transplant. 2010 Jul;25(7):2334-41. doi: 10.1093/ndt/gfq072. Epub
      2010 Mar 5.


PMID- 20207776
OWN - NLM
STAT- MEDLINE
DCOM- 20110427
LR  - 20201209
IS  - 1530-8022 (Electronic)
IS  - 0885-3282 (Linking)
VI  - 25
IP  - 5
DP  - 2011 Jan
TI  - Biocompatibility of osteogenic predifferentiated human cord blood stem cells with
      biomaterials and the influence of the biomaterial on the process of
      differentiation.
PG  - 497-512
LID - 10.1177/0885328209358631 [doi]
AB  - Modern cell-based bone reconstruction therapies offer new therapeutic
      opportunities and tissue engineering represents a more biological-oriented
      approach to heal bone defects of the skeleton. Human unrestricted somatic stem
      cells (USSCs) derived form umbilical cord blood offer new promising aspects e.g.,
      can differentiate into osteogenetic cells. Furthermore these cells have fewer
      ethical and legal restrictions compared to embryonic stem cells (ESCs). The
      purpose of this study was to evaluate the compatibility of osteogenic
      pre-differentiated USSCs with various biomaterials and to address the question,
      whether biomaterials influence the process of differentiation of the USSCs. After
      osteogenic differentiation with DAG USSCs were cultivated with various
      biomaterials. To asses the biocompatibility of USSCs the attachment and the
      proliferation of the cells on the biomaterial were measured by a CyQUANT((R))
      assay, the morphology was analyzed by scanning electron microscopy and the
      influence of the gene expression was analyzed by real time PCR. Our results
      provide evidence that insoluble collagenous bone matrix followed by
      beta-tricalciumphosphate is highly suitable for bone tissue engineering regarding
      cell attachment and proliferation. The gene expression analysis indicates that
      biomaterials influence the gene expression of USSCs. These results are in
      concordance with our previous study with ESCs.
FAU - Naujoks, Christian
AU  - Naujoks C
AD  - Department for Cranio- and Maxillofacial Surgery, Heinrich-Heine-University
      Dusseldorf, Moorenstr. 5, 40225 Dusseldorf, Germany.
FAU - Langenbach, Fabian
AU  - Langenbach F
FAU - Berr, Karin
AU  - Berr K
FAU - Depprich, Rita
AU  - Depprich R
FAU - Kubler, Norbert
AU  - Kubler N
FAU - Meyer, Ulrich
AU  - Meyer U
FAU - Handschel, Jorg
AU  - Handschel J
FAU - Kogler, Gesine
AU  - Kogler G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100305
PL  - England
TA  - J Biomater Appl
JT  - Journal of biomaterials applications
JID - 8813912
RN  - 0 (Biocompatible Materials)
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Collagen Type I)
RN  - 0 (DNA Primers)
RN  - 0 (NID2 protein, human)
RN  - EC 3.1.3.1 (Alkaline Phosphatase)
SB  - IM
MH  - Alkaline Phosphatase/genetics
MH  - Animals
MH  - Base Sequence
MH  - *Biocompatible Materials
MH  - Calcium-Binding Proteins
MH  - Cattle
MH  - Cell Adhesion
MH  - Cell Adhesion Molecules/genetics
MH  - Cell Differentiation
MH  - Cell Proliferation
MH  - Cells, Cultured
MH  - Collagen Type I/genetics
MH  - DNA Primers/genetics
MH  - Embryonic Stem Cells/*cytology/metabolism
MH  - Fetal Blood/*cytology/metabolism
MH  - Gene Expression
MH  - Humans
MH  - Infant, Newborn
MH  - Materials Testing
MH  - Microscopy, Electron, Scanning
MH  - *Osteogenesis/genetics
MH  - Tissue Engineering
MH  - Tissue Scaffolds
EDAT- 2010/03/09 06:00
MHDA- 2011/04/28 06:00
CRDT- 2010/03/09 06:00
PHST- 2010/03/09 06:00 [entrez]
PHST- 2010/03/09 06:00 [pubmed]
PHST- 2011/04/28 06:00 [medline]
AID - 0885328209358631 [pii]
AID - 10.1177/0885328209358631 [doi]
PST - ppublish
SO  - J Biomater Appl. 2011 Jan;25(5):497-512. doi: 10.1177/0885328209358631. Epub 2010
      Mar 5.


PMID- 20206984
OWN - NLM
STAT- MEDLINE
DCOM- 20100806
LR  - 20191210
IS  - 1879-3231 (Electronic)
IS  - 0093-691X (Linking)
VI  - 73
IP  - 8
DP  - 2010 May
TI  - Prediction of estrus cyclicity in Asian elephants (Elephas maximus) through
      estimation of fecal progesterone metabolite: development of an enzyme-linked
      immuno-sorbent assay.
PG  - 1051-60
LID - 10.1016/j.theriogenology.2010.01.004 [doi]
AB  - Asian elephants (Elephas maximus), prominent "flagship species", are listed under
      the category of endangered species (EN - A2c, ver. 3.1; IUCN Red List 2009) and
      there is a need for their conservation. This requires understanding demographic
      and reproductive dynamics of the species. Monitoring reproductive status of any
      species is traditionally being carried out through invasive blood sampling and
      this is restrictive for large animals such as wild or semi-captive elephants due 
      to legal, ethical, and practical reasons. Hence, there is a need for a
      non-invasive technique to assess reproductive cyclicity profiles of elephants,
      which will help in the species' conservation strategies. In this study, we
      developed an indirect competitive enzyme linked immuno-sorbent assay (ELISA) to
      estimate the concentration of one of the progesterone-metabolites i.e.,
      allopregnanolone (5 alpha-P-3OH) in fecal samples of Asian elephants. We
      validated the assay which had a sensitivity of 0.25 microM at 90% binding with an
      EC(50) value of 1.37 microM. Using female elephants, kept under semi-captive
      conditions in the forest camps of Mudumalai Wildlife Sanctuary, Tamil Nadu and
      Bandipur National Park, Karnataka, India, we measured fecal
      progesterone-metabolite (5 alpha-P-3OH) concentrations in six animals and showed 
      their clear correlation with those of serum progesterone, measured by a standard 
      radio-immuno assay. Statistical analyses using a Linear Mixed Effect model showed
      a positive correlation (P<0.1) between the profiles of fecal 5 alpha-P-3OH
      (range: 0.5-10 microg/g) and serum progesterone (range: 0.1-1.8 ng/mL).
      Therefore, our studies show, for the first time, that the fecal
      progesterone-metabolite assay could be exploited to predict estrus cyclicity and 
      to potentially assess the reproductive status of captive and free-ranging female 
      Asian elephants, thereby helping to plan their breeding strategy.
CI  - (c) 2010 Elsevier Inc. All rights reserved.
FAU - Ghosal, R
AU  - Ghosal R
AD  - Center for Ecological Sciences, Indian Institute of Science, Bangalore 560012,
      India.
FAU - Sukumar, R
AU  - Sukumar R
FAU - Seshagiri, P B
AU  - Seshagiri PB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20100305
PL  - United States
TA  - Theriogenology
JT  - Theriogenology
JID - 0421510
RN  - 4G7DS2Q64Y (Progesterone)
RN  - BXO86P3XXW (Pregnanolone)
SB  - IM
MH  - Animals
MH  - Antibody Specificity
MH  - Elephants/blood/*metabolism/*physiology
MH  - Enzyme-Linked Immunosorbent Assay/methods
MH  - Estrous Cycle/blood/metabolism/physiology
MH  - Estrus Detection/*methods
MH  - Feces/*chemistry
MH  - Female
MH  - Pregnanolone/*analysis/immunology/metabolism
MH  - Progesterone/blood/immunology/*metabolism
MH  - Sensitivity and Specificity
MH  - Sexual Behavior, Animal/physiology
EDAT- 2010/03/09 06:00
MHDA- 2010/08/07 06:00
CRDT- 2010/03/09 06:00
PHST- 2009/10/02 00:00 [received]
PHST- 2010/01/10 00:00 [revised]
PHST- 2010/01/12 00:00 [accepted]
PHST- 2010/03/09 06:00 [entrez]
PHST- 2010/03/09 06:00 [pubmed]
PHST- 2010/08/07 06:00 [medline]
AID - S0093-691X(10)00024-5 [pii]
AID - 10.1016/j.theriogenology.2010.01.004 [doi]
PST - ppublish
SO  - Theriogenology. 2010 May;73(8):1051-60. doi:
      10.1016/j.theriogenology.2010.01.004. Epub 2010 Mar 5.


PMID- 20206954
OWN - NLM
STAT- MEDLINE
DCOM- 20100805
LR  - 20181201
IS  - 1878-3503 (Electronic)
IS  - 0035-9203 (Linking)
VI  - 104
IP  - 5
DP  - 2010 May
TI  - Do colloids in comparison to crystalloids for fluid resuscitation improve
      mortality?
PG  - 311-2
LID - 10.1016/j.trstmh.2010.02.001 [doi]
AB  - Permanent neurological impairment or death arising from hospital-acquired
      hyponatremia in both children and adults is well documented. The choice of
      intravenous fluids for fluid resuscitation in critically ill patients is a top
      priority in evidence-based medicine. The question of whether colloids in
      comparison to crystalloids can improve mortality in such cases remains to be
      answered. Well powered, randomized clinical trials addressing the comparative
      efficacy of different types of intravenous fluids is a high priority as is the
      ethical justification for such trials. The understanding of the
      pathophysiological process serves important information on clinical practice.
CI  - Copyright 2010 Royal Society of Tropical Medicine and Hygiene. Published by
      Elsevier Ltd. All rights reserved.
FAU - Naing, Cho-Min
AU  - Naing CM
AD  - School of Medical Sciences, International Medical University, Kuala Lumpur 57000,
      Malaysia. cho3699@gmail.com
FAU - Win, Daw-Khin
AU  - Win DK
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100305
PL  - England
TA  - Trans R Soc Trop Med Hyg
JT  - Transactions of the Royal Society of Tropical Medicine and Hygiene
JID - 7506129
RN  - 0 (Colloids)
RN  - 0 (Crystalloid Solutions)
RN  - 0 (Isotonic Solutions)
RN  - 0 (Plasma Substitutes)
RN  - 0 (Rehydration Solutions)
SB  - IM
MH  - Adult
MH  - Child
MH  - Colloids/adverse effects/*therapeutic use
MH  - Critical Illness/mortality/*therapy
MH  - Crystalloid Solutions
MH  - Fluid Therapy/adverse effects/*methods
MH  - Humans
MH  - Hyponatremia/etiology/mortality
MH  - Infusions, Intravenous
MH  - Isotonic Solutions/adverse effects/*therapeutic use
MH  - Plasma Substitutes/adverse effects/*therapeutic use
MH  - *Rehydration Solutions/adverse effects
MH  - Resuscitation/methods
RF  - 5
EDAT- 2010/03/09 06:00
MHDA- 2010/08/06 06:00
CRDT- 2010/03/09 06:00
PHST- 2009/07/24 00:00 [received]
PHST- 2010/02/03 00:00 [revised]
PHST- 2010/02/03 00:00 [accepted]
PHST- 2010/03/09 06:00 [entrez]
PHST- 2010/03/09 06:00 [pubmed]
PHST- 2010/08/06 06:00 [medline]
AID - S0035-9203(10)00046-5 [pii]
AID - 10.1016/j.trstmh.2010.02.001 [doi]
PST - ppublish
SO  - Trans R Soc Trop Med Hyg. 2010 May;104(5):311-2. doi:
      10.1016/j.trstmh.2010.02.001. Epub 2010 Mar 5.


PMID- 20206482
OWN - NLM
STAT- MEDLINE
DCOM- 20100714
LR  - 20100405
IS  - 1769-664X (Electronic)
IS  - 0929-693X (Linking)
VI  - 17
IP  - 4
DP  - 2010 Apr
TI  - [Palliative care in the neonatal period. Part one: general considerations].
PG  - 409-12
LID - 10.1016/j.arcped.2010.01.018 [doi]
AB  - In France, the law dated 22 April 2005 required that all practitioners offer
      palliative care to patients as an alternative to unreasonable obstinacy. The
      practical development of palliative care during the neonatal period is not easy, 
      even though obstetricians and neonatologists have always been aware of the
      ethical necessity of comfort in the dying newborn. The decision leading to
      palliative care begins with the recognition of patent or potential unreasonable
      obstinacy, followed by withdrawing treatment and technical support, and finally a
      palliative care plan is drawn up with the medical team and the parents.
CI  - Copyright 2010. Published by Elsevier SAS.. All rights reserved.
FAU - Betremieux, P
AU  - Betremieux P
AD  - Unite de reanimation pediatrique, hopital Sud, CHU de Rennes, 16, boulevard de
      Bulgarie, 35203 Rennes cedex 2, France. pierre.betremieux@chu-rennes.fr
FAU - Gold, F
AU  - Gold F
FAU - Parat, S
AU  - Parat S
FAU - Caeymaex, L
AU  - Caeymaex L
FAU - Danan, C
AU  - Danan C
FAU - De Dreuzy, P
AU  - De Dreuzy P
FAU - Vernier, D
AU  - Vernier D
FAU - Viallard, M-L
AU  - Viallard ML
FAU - Kuhn, P
AU  - Kuhn P
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Reflexions et propositions autour des soins palliatifs en periode neonatale :
      1(re) partie considerations generales.
DEP - 20100304
PL  - France
TA  - Arch Pediatr
JT  - Archives de pediatrie : organe officiel de la Societe francaise de pediatrie
JID - 9421356
SB  - IM
MH  - Adult
MH  - Child
MH  - Congenital Abnormalities/diagnosis/*therapy
MH  - Cooperative Behavior
MH  - Decision Making
MH  - *Ethics, Medical
MH  - France
MH  - Humans
MH  - Infant, Extremely Low Birth Weight
MH  - Infant, Newborn
MH  - Infant, Premature, Diseases/diagnosis/*therapy
MH  - Interdisciplinary Communication
MH  - Life Support Care/ethics/legislation & jurisprudence
MH  - Palliative Care/*ethics/legislation & jurisprudence
MH  - Patient Care Team/ethics/legislation & jurisprudence
MH  - Professional-Family Relations
MH  - Withholding Treatment/ethics/legislation & jurisprudence
EDAT- 2010/03/09 06:00
MHDA- 2010/07/16 06:00
CRDT- 2010/03/09 06:00
PHST- 2009/07/20 00:00 [received]
PHST- 2009/10/29 00:00 [revised]
PHST- 2010/01/04 00:00 [accepted]
PHST- 2010/03/09 06:00 [entrez]
PHST- 2010/03/09 06:00 [pubmed]
PHST- 2010/07/16 06:00 [medline]
AID - S0929-693X(10)00039-4 [pii]
AID - 10.1016/j.arcped.2010.01.018 [doi]
PST - ppublish
SO  - Arch Pediatr. 2010 Apr;17(4):409-12. doi: 10.1016/j.arcped.2010.01.018. Epub 2010
      Mar 4.


PMID- 20206355
OWN - NLM
STAT- MEDLINE
DCOM- 20100817
LR  - 20161229
IS  - 1879-3479 (Electronic)
IS  - 0020-7292 (Linking)
VI  - 109
IP  - 3
DP  - 2010 Jun
TI  - Unethical female stereotyping in reproductive health.
PG  - 255-8
LID - 10.1016/j.ijgo.2010.02.002 [doi]
AB  - Stereotypes are generalized preconceptions defining individuals by group
      categories into which they are placed. Women have become stereotyped as
      homemakers and mothers, with the negative effect of precluding them from other
      roles and functions. Legislation and judicial constructions show a history, and
      often a continuing practice, of confining women to these stereotypical functions.
      In access to reproductive and sexual health care, for instance, women's requests 
      have been professionally subject to approval of their husbands, fathers or
      comparable males. Choice of abortion is particularly significant, because it
      embeds moral values. Women's capacity to act as responsible moral agents is
      denied by stereotypical attitudes shown by legislators, judges, heads of
      religious denominations, and healthcare providers who consider women incapable of
      exercising responsible moral choice. These attitudes violate ethical requirements
      of treating patients with respect and equal justice. They can also result in
      violations of human rights laws that prohibit discrimination against women.
CI  - Copyright 2010 International Federation of Gynecology and Obstetrics. Published
      by Elsevier Ireland Ltd. All rights reserved.
FAU - Cook, Rebecca J
AU  - Cook RJ
AD  - Faculty of Law, Faculty of Medicine and Joint Centre for Bioethics, University of
      Toronto, Toronto, Canada M5S 2C5.
FAU - Cusack, Simone
AU  - Cusack S
FAU - Dickens, Bernard M
AU  - Dickens BM
LA  - eng
PT  - Journal Article
DEP - 20100304
PL  - United States
TA  - Int J Gynaecol Obstet
JT  - International journal of gynaecology and obstetrics: the official organ of the
      International Federation of Gynaecology and Obstetrics
JID - 0210174
SB  - IM
MH  - Female
MH  - Humans
MH  - Male
MH  - Prejudice
MH  - Reproductive Medicine/*ethics/legislation & jurisprudence
MH  - Reproductive Rights/*ethics/legislation & jurisprudence
MH  - *Stereotyping
MH  - Women's Health/ethics/legislation & jurisprudence
MH  - Women's Health Services/ethics/legislation & jurisprudence
MH  - Women's Rights/ethics/legislation & jurisprudence
EDAT- 2010/03/09 06:00
MHDA- 2010/08/18 06:00
CRDT- 2010/03/09 06:00
PHST- 2010/03/09 06:00 [entrez]
PHST- 2010/03/09 06:00 [pubmed]
PHST- 2010/08/18 06:00 [medline]
AID - S0020-7292(10)00061-5 [pii]
AID - 10.1016/j.ijgo.2010.02.002 [doi]
PST - ppublish
SO  - Int J Gynaecol Obstet. 2010 Jun;109(3):255-8. doi: 10.1016/j.ijgo.2010.02.002.
      Epub 2010 Mar 4.


PMID- 20206041
OWN - NLM
STAT- MEDLINE
DCOM- 20100610
LR  - 20131121
IS  - 1526-3231 (Electronic)
IS  - 0749-8063 (Linking)
VI  - 26
IP  - 3
DP  - 2010 Mar
TI  - Effect of suture size and type on bone cutout in transosseous tendon repairs.
PG  - 324-7
LID - 10.1016/j.arthro.2009.08.020 [doi]
AB  - PURPOSE: We compared bone cutout of polyester and polyblend suture in 2 suture
      sizes with static and cyclic loading in a Sawbone model (Pacific Research
      Laboratories, Vashon, WA). METHODS: Polyester and polyblend sutures in both No. 2
      and No. 5 sizes were placed through transosseous tunnels in closed-cell
      polyurethane foam and tied over the bar of an electromechanical load frame at a
      fixed height. Seven sutures in each group were pulled at a rate of 1 mm/s until
      bone cutout occurred. Another set of 28 sutures were cyclically loaded at
      increasing loads until failure. RESULTS: With static and cyclic loads, No. 5
      polyester suture (Ethibond; Ethicon, Somerville, NJ) and No. 5 polyblend suture
      (FiberWire; Arthrex, Naples, FL) had a higher cutout load than the No. 2 sutures 
      (P < .001). No. 2 polyblend suture had a higher static failure load than No. 2
      polyester suture (P = .02). With cyclic loading, No. 2 polyblend suture had a
      higher load to cutout than No. 2 polyester suture (P = .01), and No. 5 polyblend 
      suture had a higher load to cutout than No. 5 polyester suture (P = .003).
      CONCLUSIONS: No. 2 sutures showed bone cutout at lower forces under static and
      cyclic loading as compared with No. 5 sutures in this Sawbone model, and no
      decrease in performance with regard to bone cutout was noted with polyblend as
      compared with polyester. CLINICAL RELEVANCE: No. 5 polyester or polyblend suture 
      may be preferable to No. 2 suture to avoid bone cutout in tendon-to-bone repair, 
      and No. 5 polyblend may be preferable to No. 5 polyester to avoid bone cutout.
CI  - Copyright 2010 Arthroscopy Association of North America. Published by Elsevier
      Inc. All rights reserved.
FAU - Norris, Joseph B
AU  - Norris JB
AD  - Department of Orthopaedic Surgery, Union Memorial Hospital, Baltimore, Maryland
      21218, USA.
FAU - Smith, Robert T
AU  - Smith RT
FAU - White, Kacey L
AU  - White KL
FAU - Parks, Brent G
AU  - Parks BG
FAU - O'Donnell, John B
AU  - O'Donnell JB
LA  - eng
PT  - Journal Article
DEP - 20100125
PL  - United States
TA  - Arthroscopy
JT  - Arthroscopy : the journal of arthroscopic & related surgery : official
      publication of the Arthroscopy Association of North America and the International
      Arthroscopy Association
JID - 8506498
RN  - 0 (Polyesters)
RN  - 0 (Polyurethanes)
SB  - IM
MH  - Analysis of Variance
MH  - Biomechanical Phenomena
MH  - Equipment Failure Analysis
MH  - Materials Testing
MH  - Polyesters
MH  - Polyurethanes
MH  - Stress, Mechanical
MH  - Suture Techniques
MH  - *Sutures
MH  - Tendon Injuries/*surgery
EDAT- 2010/03/09 06:00
MHDA- 2010/06/11 06:00
CRDT- 2010/03/09 06:00
PHST- 2009/03/12 00:00 [received]
PHST- 2009/06/24 00:00 [revised]
PHST- 2009/08/30 00:00 [accepted]
PHST- 2010/03/09 06:00 [entrez]
PHST- 2010/03/09 06:00 [pubmed]
PHST- 2010/06/11 06:00 [medline]
AID - S0749-8063(09)00779-8 [pii]
AID - 10.1016/j.arthro.2009.08.020 [doi]
PST - ppublish
SO  - Arthroscopy. 2010 Mar;26(3):324-7. doi: 10.1016/j.arthro.2009.08.020. Epub 2010
      Jan 25.


PMID- 20205976
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20151119
IS  - 1486-3847 (Print)
IS  - 1486-3847 (Linking)
VI  - 71
IP  - 1
DP  - 2010 Spring
TI  - Perceived roles, benefits, and supports for dietetic internship preceptors.
PG  - 33-8
AB  - Evaluation of university-run dietetic internship programs will improve
      preceptors' experience and, ultimately, increase the capacity for training future
      dietitians. We attempted to identify preceptors' perceptions of their roles,
      benefits, and supports, as well as of the skills/traits that students need for
      internship, and suggested improvements for the internship program. Fifteen of 39 
      current program preceptors who had supervised more than one intern consented to
      participate in an ethics-approved research methodology. They responded
      anonymously to a series of questions posted in an online discussion group, and
      provided feedback on the subsequent reports. While no consensus emerged, more
      than 50% of participants perceived their role as providing a supportive learning 
      experience for interns. Benefits noted most frequently were personal academic
      growth and contributions to their organizations from intern research projects.
      Effective supports included conventional communication methods and website
      materials. Participants identified self-motivation, independence, and
      communication skills as most important for interns. They also provided several
      suggestions for program improvements. The study methods and results could be
      helpful to other university-run internship programs seeking improvement and
      growth.
FAU - Ortman, Deanne
AU  - Ortman D
AD  - Dietetics and Internship Education Program, Department of Applied Human
      Nutrition, Mount Saint Vincent University, Halifax, NS.
FAU - Mann, Linda
AU  - Mann L
FAU - Arsenault, Judy Fraser
AU  - Arsenault JF
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Canada
TA  - Can J Diet Pract Res
JT  - Canadian journal of dietetic practice and research : a publication of Dietitians 
      of Canada = Revue canadienne de la pratique et de la recherche en dietetique :
      une publication des Dietetistes du Canada
JID - 9811151
SB  - IM
MH  - Dietetics/*education
MH  - Focus Groups
MH  - Humans
MH  - Preceptorship/*standards
MH  - Problem-Based Learning
MH  - Program Evaluation
MH  - Surveys and Questionnaires
EDAT- 2010/03/09 06:00
MHDA- 2011/10/25 06:00
CRDT- 2010/03/09 06:00
PHST- 2010/03/09 06:00 [entrez]
PHST- 2010/03/09 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
AID - 10.3148/71.1.2010.33 [doi]
PST - ppublish
SO  - Can J Diet Pract Res. 2010 Spring;71(1):33-8. doi: 10.3148/71.1.2010.33.


PMID- 20205791
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20100609
LR  - 20220409
IS  - 1748-5908 (Electronic)
IS  - 1748-5908 (Linking)
VI  - 5
DP  - 2010 Jan 15
TI  - Overview of a formal scoping review on health system report cards.
PG  - 2
LID - 10.1186/1748-5908-5-2 [doi]
AB  - BACKGROUND: There is an extensive body of literature on health system quality
      reporting that has yet to be characterized. Scoping is a novel methodology for
      systematically assessing the breadth of a body of literature in a particular
      research area. Our objectives were to showcase the scoping review methodology in 
      the review of health system quality reporting, and to report on the extent of the
      literature in this area. METHODS: A scoping review was performed based on the
      York methodology outlined by Arksey and O'Malley from the University of York,
      United Kingdom. We searched 14 peer reviewed and grey literature databases
      limiting the search to English language and non-English language articles with
      English abstracts published between 1980 and June 2006 with an update to November
      2008. We also searched specific websites, reference lists, and key journals for
      relevant material and solicited input from key stakeholders. Inclusion/exclusion 
      criteria were applied to select relevant material and qualitative information was
      charted from the selected literature. RESULTS: A total of 10,102 articles were
      identified from searching the literature databases, 821 were deemed relevant to
      our scoping review. An additional 401 were identified from updates, website
      searching, references lists, key journals, and stakeholder suggestions for a
      total of 1,222 included articles. These were categorized and catalogued according
      to the inclusion criteria, and further subcategories were identified through the 
      charting process. Topic areas represented by this review included the
      effectiveness of health system report cards (n = 194 articles), methodological
      issues in their development (n = 815 articles), stakeholder views on report cards
      (n = 144 articles), and ethical considerations around their development (n = 69
      articles). CONCLUSIONS: The scoping review methodology has permitted us to
      characterize and catalogue the extensive body of literature pertaining to health 
      system report cards. The resulting literature repository that our review has
      created can be of use to researchers and health system stakeholders interested in
      the topic of health system quality measurement and reporting.
FAU - Brien, Susan E
AU  - Brien SE
AD  - Department of Community Health Sciences, Faculty of Medicine, University of
      Calgary, Calgary, Canada. sbrien@ucalgary.ca
FAU - Lorenzetti, Diane L
AU  - Lorenzetti DL
FAU - Lewis, Steven
AU  - Lewis S
FAU - Kennedy, James
AU  - Kennedy J
FAU - Ghali, William A
AU  - Ghali WA
LA  - eng
PT  - Journal Article
DEP - 20100115
PL  - England
TA  - Implement Sci
JT  - Implementation science : IS
JID - 101258411
PMC - PMC2823624
EDAT- 2010/03/09 06:00
MHDA- 2010/03/09 06:01
CRDT- 2010/03/09 06:00
PHST- 2008/07/15 00:00 [received]
PHST- 2010/01/15 00:00 [accepted]
PHST- 2010/03/09 06:00 [entrez]
PHST- 2010/03/09 06:00 [pubmed]
PHST- 2010/03/09 06:01 [medline]
AID - 1748-5908-5-2 [pii]
AID - 10.1186/1748-5908-5-2 [doi]
PST - epublish
SO  - Implement Sci. 2010 Jan 15;5:2. doi: 10.1186/1748-5908-5-2.


PMID- 20205778
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20190108
IS  - 1472-684X (Electronic)
IS  - 1472-684X (Linking)
VI  - 9
DP  - 2010 Jan 7
TI  - What "best practice" could be in Palliative Care: an analysis of statements on
      practice and ethics expressed by the main Health Organizations.
PG  - 1
LID - 10.1186/1472-684X-9-1 [doi]
AB  - BACKGROUND: In palliative care it would be necessary to refer to a model.
      Nevertheless it seems that there are no official statements which state and
      describe that model. We carried out an analysis of the statements on practice and
      ethics of palliative care expressed by the main health organizations to show
      which dimensions of end-of-life care are taken into consideration. METHODS: The
      official documents by the most representative health organisations committed to
      the definition of policies and guidelines for palliative and end-of-life care had
      been considered. The documents were analysed through a framework of the
      components of end-of-life care derived from literature, which was composed of 4
      main "areas" and of 12 "sub-areas". RESULTS: Overall, 34 organizations were
      identified, 7 international organisations, and 27 organisations operating on the 
      national level in four different countries (Australia, Canada, UK and United
      States). Up to 56 documents were selected and analysed. Most of them (38) are
      position statements. Relevant quotations from the documents were presented by
      "areas" and "sub-areas". In general, the "sub-areas" of symptoms control as well 
      as those referring to relational and social issues are more widely covered by the
      documents than the "sub-areas" related to "preparation" and to "existential
      condition". Indeed, the consistency of end-of-life choices with the patient's
      wishes, as well as completion and meaningfulness at the end of life is given only
      a minor relevance. CONCLUSIONS: An integrated model of the best palliative care
      practice is generally lacking in the documents. It might be argued that the lack 
      of a fixed and coherent model is due to the relevance of unavoidable context
      issues in palliative care, such as specific cultural settings, patient-centred
      variables, and family specificity. The implication is that palliative care staff 
      have continuously to adapt their model of caring to the specific needs and values
      of each patient, more than applying a fixed, although maybe comprehensive, care
      model.
FAU - Barazzetti, Gaia
AU  - Barazzetti G
AD  - ISPO Institute for the study and prevention of cancer Florence - Italy.
      g.miccinesi@ispo.toscana.it.
FAU - Borreani, Claudia
AU  - Borreani C
FAU - Miccinesi, Guido
AU  - Miccinesi G
FAU - Toscani, Franco
AU  - Toscani F
LA  - eng
PT  - Journal Article
DEP - 20100107
PL  - England
TA  - BMC Palliat Care
JT  - BMC palliative care
JID - 101088685
PMC - PMC2823604
EDAT- 2010/03/09 06:00
MHDA- 2010/03/09 06:01
CRDT- 2010/03/09 06:00
PHST- 2009/03/09 00:00 [received]
PHST- 2010/01/07 00:00 [accepted]
PHST- 2010/03/09 06:00 [entrez]
PHST- 2010/03/09 06:00 [pubmed]
PHST- 2010/03/09 06:01 [medline]
AID - 1472-684X-9-1 [pii]
AID - 10.1186/1472-684X-9-1 [doi]
PST - epublish
SO  - BMC Palliat Care. 2010 Jan 7;9:1. doi: 10.1186/1472-684X-9-1.


PMID- 20205768
OWN - NLM
STAT- MEDLINE
DCOM- 20101213
LR  - 20220316
IS  - 1758-2652 (Electronic)
IS  - 1758-2652 (Linking)
VI  - 13
DP  - 2010 Jan 12
TI  - Highly active antiretroviral treatment for the prevention of HIV transmission.
PG  - 1
LID - 10.1186/1758-2652-13-1 [doi]
AB  - In 2007 an estimated 33 million people were living with HIV; 67% resided in
      sub-Saharan Africa, with 35% in eight countries alone. In 2007, there were about 
      1.4 million HIV-positive tuberculosis cases. Globally, approximately 4 million
      people had been given highly active antiretroviral therapy (HAART) by the end of 
      2008, but in 2007, an estimated 6.7 million were still in need of HAART and 2.7
      million more became infected with HIV.Although there has been unprecedented
      investment in confronting HIV/AIDS - the Joint United Nations Programme on
      HIV/AIDS estimates $13.8 billion was spent in 2008 - a key challenge is how to
      address the HIV/AIDS epidemic given limited and potentially shrinking resources. 
      Economic disparities may further exacerbate human rights issues and widen the
      increasingly divergent approaches to HIV prevention, care and treatment.HIV
      transmission only occurs from people with HIV, and viral load is the single
      greatest risk factor for all modes of transmission. HAART can lower viral load to
      nearly undetectable levels. Prevention of mother to child transmission offers
      proof of the concept of HAART interrupting transmission, and observational
      studies and previous modelling work support using HAART for prevention. Although 
      knowing one's HIV status is key for prevention efforts, it is not known with
      certainty when to start HAART.Building on previous modelling work, we used an
      HIV/AIDS epidemic of South African intensity to explore the impact of testing all
      adults annually and starting persons on HAART immediately after they are
      diagnosed as HIV positive. This theoretical strategy would reduce annual HIV
      incidence and mortality to less than one case per 1000 people within 10 years and
      it would reduce the prevalence of HIV to less than 1% within 50 years. To explore
      HAART as a prevention strategy, we recommend further discussions to explore human
      rights and ethical considerations, clarify research priorities and review
      feasibility and acceptability issues.
FAU - Granich, Reuben
AU  - Granich R
AD  - Department of HIV/AIDS, World Health Organization, Geneva, Switzerland.
      granichr@who.int
FAU - Crowley, Siobhan
AU  - Crowley S
FAU - Vitoria, Marco
AU  - Vitoria M
FAU - Lo, Ying-Ru
AU  - Lo YR
FAU - Souteyrand, Yves
AU  - Souteyrand Y
FAU - Dye, Christopher
AU  - Dye C
FAU - Gilks, Charlie
AU  - Gilks C
FAU - Guerma, Teguest
AU  - Guerma T
FAU - De Cock, Kevin M
AU  - De Cock KM
FAU - Williams, Brian
AU  - Williams B
LA  - eng
PT  - Journal Article
DEP - 20100112
PL  - Switzerland
TA  - J Int AIDS Soc
JT  - Journal of the International AIDS Society
JID - 101478566
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - Anti-HIV Agents/*therapeutic use
MH  - *Antiretroviral Therapy, Highly Active
MH  - HIV Infections/*drug therapy/*prevention & control/transmission
MH  - Humans
PMC - PMC2822750
EDAT- 2010/03/09 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/03/09 06:00
PHST- 2009/09/13 00:00 [received]
PHST- 2010/01/12 00:00 [accepted]
PHST- 2010/03/09 06:00 [entrez]
PHST- 2010/03/09 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 1758-2652-13-1 [pii]
AID - 10.1186/1758-2652-13-1 [doi]
PST - epublish
SO  - J Int AIDS Soc. 2010 Jan 12;13:1. doi: 10.1186/1758-2652-13-1.


PMID- 20205666
OWN - NLM
STAT- MEDLINE
DCOM- 20100701
LR  - 20190728
IS  - 1873-4286 (Electronic)
IS  - 1381-6128 (Linking)
VI  - 16
IP  - 2
DP  - 2010
TI  - Ethical and social issues in pharmacogenomics testing.
PG  - 245-52
AB  - In genomics research, pathways that lead to disease and the role of drugs in
      these pathways are being unravelled at a high rate. In this paper ethical and
      social challenges related to pharmacogenomics research are discussed as well as
      clinical applications. In research, ethical thinking evolves due to the fast pace
      of research. Genome-wide association studies trying to identify genes that
      contribute a small risk to common diseases can only be performed on an
      international scale. Meanwhile, it is becoming more and more clear that genomic
      information is hard to hide. Thus the traditional promise in research that
      privacy will be protected appears to be less realistic. Nowadays, adequate
      information (veracity) and protection against potential risks of discrimination
      based on predictive medical information is required. A new balance needs to be
      found. In the clinic, different ethical and social challenges become apparent.
      The promise to improve diagnosis, treatment and prevention is genuine, but many
      potentially useful applications do not reach the bedside. There is a need for
      both translation and for assessment of evidence if "do good and do not harm" is
      to be taken seriously. In addition, sustainable use of pharmacogenetic knowledge 
      holds promises for developed and developing countries but these promises will
      only materialize if evidence is built, translated into guidelines, incorporated
      into education, implemented in pharmacy databases, and evaluated. While
      translational research in health care progresses slowly, direct-to-consumer
      testing is being implemented rapidly. International validated quality criteria
      should apply both to health care and to this commercial field.
FAU - Vijverberg, S J H
AU  - Vijverberg SJ
AD  - Department of Clinical Genetics/EMGO Institute, BS7, D423, VU University Medical 
      Center, PO Box 7057, NL-1007 MB Amsterdam, The Netherlands.
FAU - Pieters, T
AU  - Pieters T
FAU - Cornel, M C
AU  - Cornel MC
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Pharm Des
JT  - Current pharmaceutical design
JID - 9602487
SB  - IM
MH  - Humans
MH  - Informed Consent
MH  - *Pharmacogenetics
RF  - 42
EDAT- 2010/03/09 06:00
MHDA- 2010/07/02 06:00
CRDT- 2010/03/09 06:00
PHST- 2009/08/29 00:00 [received]
PHST- 2009/09/01 00:00 [accepted]
PHST- 2010/03/09 06:00 [entrez]
PHST- 2010/03/09 06:00 [pubmed]
PHST- 2010/07/02 06:00 [medline]
AID - CPD-M.C. Cornel (Guchelaar) [pii]
AID - 10.2174/138161210790112700 [doi]
PST - ppublish
SO  - Curr Pharm Des. 2010;16(2):245-52. doi: 10.2174/138161210790112700.


PMID- 20204619
OWN - NLM
STAT- MEDLINE
DCOM- 20100531
LR  - 20220129
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Linking)
VI  - 633
DP  - 2010
TI  - The embryonic kidney: isolation, organ culture, immunostaining and RNA
      interference.
PG  - 57-69
LID - 10.1007/978-1-59745-019-5_4 [doi]
AB  - Embryonic mouse kidneys develop well in organ culture. This, coupled with the
      fact that renal organogenesis includes a range of developmental processes, has
      made cultured kidney rudiments a popular model for the study of organogenesis.
      Although cultured kidneys do not replicate every event that takes place in vivo, 
      they do allow close observation of events as they happen and they allow easy
      access for experiments that use drugs, antibodies, exogenous growth factors and
      interfering RNAs. Renal organ culture therefore offers a much quicker method to
      address certain problems than would the generation of transgenic mice. Requiring 
      only material from freshly killed healthy animals, it also avoids some ethical
      problems connected with subjecting living animals to treatments (or the effect of
      mutations) that are harmful.
FAU - Davies, Jamie A
AU  - Davies JA
AD  - Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD,
      UK.
LA  - eng
GR  - G19227/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
RN  - 0 (Antibodies)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
SB  - IM
MH  - Animals
MH  - Antibodies/pharmacology
MH  - Dissection/*methods
MH  - Female
MH  - Fluorescent Antibody Technique
MH  - Immunohistochemistry/*methods
MH  - Intercellular Signaling Peptides and Proteins/pharmacology
MH  - Kidney/cytology/drug effects/*embryology/*metabolism
MH  - Mesoderm/cytology/metabolism
MH  - Mice
MH  - Organ Culture Techniques/*methods
MH  - Plasmids/genetics
MH  - Pregnancy
MH  - *RNA Interference
MH  - Spinal Cord/metabolism
EDAT- 2010/03/06 06:00
MHDA- 2010/06/01 06:00
CRDT- 2010/03/06 06:00
PHST- 2010/03/06 06:00 [entrez]
PHST- 2010/03/06 06:00 [pubmed]
PHST- 2010/06/01 06:00 [medline]
AID - 10.1007/978-1-59745-019-5_4 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2010;633:57-69. doi: 10.1007/978-1-59745-019-5_4.


PMID- 20204058
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20100701
LR  - 20200929
IS  - 1937-5719 (Electronic)
IS  - 1937-5719 (Linking)
VI  - 10
DP  - 2010 Feb 23
TI  - Facilitating harvest of the serratus fascial flap with ultrasonic dissection.
PG  - e18
AB  - OBJECTIVES: Upper extremity reconstruction presents a functional and aesthetic
      challenge in plastic surgery. Exposure of vital structures often requires
      vascularized soft tissue coverage to achieve primary wound healing and optimize
      functional results. Specifically, the serratus fascial flap may satisfy the
      functional and cosmetic requirements for small- to medium-sized soft tissue
      defects of the upper extremity with limited donor site morbidity. We describe our
      technique of serratus fascial flap harvest, using the Harmonic SYNERGY curved
      blade (Ethicon Endo-Surgery, Cincinnati, Ohio). MATERIAL AND METHODS: A
      21-year-old, right-hand-dominant, male carpenter and martial arts expert was
      involved in a motorcycle collision and sustained a left-hand dorsal degloving
      injury and extensor tendon rupture. Soft tissue reconstruction was performed with
      a serratus fascial free flap, immediate split-thickness skin graft, and palmaris 
      longus tendon grafts. The flap was harvested with the Harmonic blade, which
      utilizes ultrasonic energy translated into mechanical energy, thereby allowing
      dissection and hemostasis simultaneously. RESULTS: Flap elevation proceeded
      facilely using the Harmonic curved blade. The patient had no postoperative
      complications involving his flap or donor site. The closed suction drain in the
      donor site was removed on postoperative day 3, and the patient was discharged on 
      postoperative day 10. The patient is doing well at 4 months follow-up.
      CONCLUSION: The Harmonic blade may assist in the dissection of the serratus
      fascial flap by aiding with hemostasis and minimizing surrounding tissue damage. 
      This may reduce flap damage associated with harvesting techniques as well as
      decrease donor site seroma formation.
FAU - Seitz, Iris A
AU  - Seitz IA
AD  - Section of Plastic and Reconstructive Surgery, University of Chicago Medical
      Center, Chicago, IL, USA.
FAU - Williams, Craig
AU  - Williams C
FAU - Schechter, Loren S
AU  - Schechter LS
LA  - eng
PT  - Journal Article
DEP - 20100223
PL  - United States
TA  - Eplasty
JT  - Eplasty
JID - 101316107
PMC - PMC2829196
EDAT- 2010/03/06 06:00
MHDA- 2010/03/06 06:01
CRDT- 2010/03/06 06:00
PHST- 2010/03/06 06:00 [entrez]
PHST- 2010/03/06 06:00 [pubmed]
PHST- 2010/03/06 06:01 [medline]
PST - epublish
SO  - Eplasty. 2010 Feb 23;10:e18.


PMID- 20203432
OWN - NLM
STAT- MEDLINE
DCOM- 20100415
LR  - 20190608
IS  - 0916-8818 (Print)
IS  - 0916-8818 (Linking)
VI  - 56
IP  - 1
DP  - 2010 Feb
TI  - How to improve the success rate of mouse cloning technology.
PG  - 20-30
AB  - It has now been 13 years since the first cloned mammal Dolly the sheep was
      generated from somatic cells using nuclear transfer (SCNT). Since then, this
      technique has been considered an important tool not only for animal reproduction 
      but also for regenerative medicine. However, the success rate is still very low
      and the mechanisms involved in genomic reprogramming are not yet clear. Moreover,
      the NT technique requires donated fresh oocyte, which raises ethical problems for
      production of human cloned embryo. For this reason, the use of induced
      pluripotent stem cells for genomic reprogramming and for regenerative medicine is
      currently a hot topic in this field. However, we believe that the NT approach
      remains the only valid way for the study of reproduction and basic biology. For
      example, only the NT approach can reveal dynamic and global modifications in the 
      epigenome without using genetic modification, and it can generate offspring from 
      a single cell or even a frozen dead body. Thanks to much hard work by many
      groups, cloning success rates are increasing slightly year by year, and NT
      cloning is now becoming a more applicable method. This review describes how to
      improve the efficiency of cloning, the establishment of clone-derived embryonic
      stem cells and further applications.
FAU - Thuan, Nguyen Van
AU  - Thuan NV
AD  - Department of Animal Bioscience and Biotechnology, Konkuk University, South
      Korea.
FAU - Kishigami, Satoshi
AU  - Kishigami S
FAU - Wakayama, Teruhiko
AU  - Wakayama T
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - J Reprod Dev
JT  - The Journal of reproduction and development
JID - 9438792
SB  - IM
MH  - Animals
MH  - Cellular Reprogramming/physiology
MH  - Clone Cells/physiology
MH  - Cloning, Organism/*methods
MH  - Embryonic Stem Cells/*physiology
MH  - Epigenesis, Genetic
MH  - Extinction, Biological
MH  - Female
MH  - Mice
MH  - *Nuclear Transfer Techniques
MH  - Oocytes/physiology
MH  - Pluripotent Stem Cells/*physiology
RF  - 136
EDAT- 2010/03/06 06:00
MHDA- 2010/04/16 06:00
CRDT- 2010/03/06 06:00
PHST- 2010/03/06 06:00 [entrez]
PHST- 2010/03/06 06:00 [pubmed]
PHST- 2010/04/16 06:00 [medline]
AID - JST.JSTAGE/jrd/09-221A [pii]
AID - 10.1262/jrd.09-221a [doi]
PST - ppublish
SO  - J Reprod Dev. 2010 Feb;56(1):20-30. doi: 10.1262/jrd.09-221a.


PMID- 20203162
OWN - NLM
STAT- MEDLINE
DCOM- 20100812
LR  - 20191210
IS  - 1555-905X (Electronic)
IS  - 1555-9041 (Linking)
VI  - 5
IP  - 5
DP  - 2010 May
TI  - Kidney transplantation and HIV: does recipient privacy outweigh the donor's right
      to information?
PG  - 924-8
LID - 10.2215/CJN.06820909 [doi]
AB  - BACKGROUND AND OBJECTIVES: There exists an inherent conflict between a kidney
      donor's right to know key aspects of a recipient's medical history and specific
      disease, such as HIV, where federal and state statues protect this information.
      The authors of the live organ donor consensus group expressly stated the
      principal of a donor's right to recipient information. This information includes 
      the risks and benefits of not only the donation procedure, but also the risks,
      benefits, and alternative treatment options of the recipient. In this paper, a
      case will be presented highlighting this conflict and the ethical and legal
      reasoning used to resolve it. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: A
      22-year-old woman came forward as a directed kidney donor for an HIV-positive
      individual. The donor and recipient were medically appropriate for kidney
      donation and transplantation. During the donor advocacy panel review, there was
      disagreement regarding whether or not the potential donor had the right to know
      about the HIV status of the potential recipient. RESULTS: In living kidney
      transplantation to HIV-positive individuals, the recipient's right to privacy of 
      information outweighs the donor's right to know. CONCLUSIONS: Although protecting
      the recipient's right to privacy is paramount, the donor is still entitled to
      consider factors a priori that could alter their decision to donate. This can be 
      accomplished by informing the donor that they are not entitled to protected
      health information of the recipient and that their decision to donate should be
      based on knowing the recipient is medically appropriate for kidney
      transplantation.
FAU - Formica, Richard N Jr
AU  - Formica RN Jr
AD  - Yale University School of Medicine, Department of Medicine, Section of
      Nephrology, Boardman 124, PO Box 208029, 330 Cedar Street, New Haven, CT
      06520-8029, USA. richard.formica@yale.edu
FAU - Asch, William S
AU  - Asch WS
FAU - Wagner, Krystn R
AU  - Wagner KR
FAU - Kulkarni, Sanjay
AU  - Kulkarni S
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20100304
PL  - United States
TA  - Clin J Am Soc Nephrol
JT  - Clinical journal of the American Society of Nephrology : CJASN
JID - 101271570
SB  - IM
MH  - Confidentiality/*ethics/legislation & jurisprudence
MH  - Conflict, Psychological
MH  - Directed Tissue Donation/*ethics/legislation & jurisprudence
MH  - Female
MH  - Government Regulation
MH  - HIV Infections/*complications
MH  - Health Policy
MH  - Humans
MH  - Kidney Failure, Chronic/complications/*surgery
MH  - Kidney Transplantation/*ethics/legislation & jurisprudence
MH  - Tissue Donors/*ethics/legislation & jurisprudence
MH  - Truth Disclosure/*ethics
MH  - United States
MH  - Young Adult
PMC - PMC2863980
EDAT- 2010/03/06 06:00
MHDA- 2010/08/13 06:00
CRDT- 2010/03/06 06:00
PHST- 2010/03/06 06:00 [entrez]
PHST- 2010/03/06 06:00 [pubmed]
PHST- 2010/08/13 06:00 [medline]
AID - CJN.06820909 [pii]
AID - 10.2215/CJN.06820909 [doi]
PST - ppublish
SO  - Clin J Am Soc Nephrol. 2010 May;5(5):924-8. doi: 10.2215/CJN.06820909. Epub 2010 
      Mar 4.


PMID- 20203117
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20210402
IS  - 1936-959X (Electronic)
IS  - 0195-6108 (Linking)
VI  - 31
IP  - 5
DP  - 2010 May
TI  - White matter characteristics and cognition in prenatally opiate- and
      polysubstance-exposed children: a diffusion tensor imaging study.
PG  - 894-900
LID - 10.3174/ajnr.A1957 [doi]
AB  - BACKGROUND AND PURPOSE: Prenatal drug exposure may influence the developing
      brain. Our aim was to study WM characteristics with DTI in children with prenatal
      opiate and polysubstance exposure and in controls. We assessed whether group
      differences in FA, DA, and DR could be found and related to cognitive function.
      MATERIALS AND METHODS: The study was approved by a committee for medical research
      ethics. Parents signed an informed consent; children gave spoken consent. Our
      sample included 14 prenatally substance-exposed adopted children (5 girls; age
      range, 8.6-13.9 years; mean, 11.3 +/- 1.7 years) and 14 control children (7
      girls; age range, 9.0-10.2 years; mean, 9.8 +/- 0.3 years). Tract-based spatial
      statistics were used to define a common WM skeleton for the sample, and FA was
      compared between groups throughout the skeleton, controlling for age and sex.
      Clusters of significant group differences >or=100 voxels (P <. 05) were
      identified. FA, DA, and DR within clusters were correlated with cognitive
      function. RESULTS: Ten clusters of FA group differences, mostly in central,
      posterior, and inferior parts of the brain, were identified (P <. 05), showing
      lower FA in substance-exposed children. FA and DA correlated positively and DR,
      negatively with cognitive function across groups. CONCLUSIONS: Prenatally
      substance-exposed children exhibited lower FA in restricted areas of WM, mostly
      relatively central, inferior, and posterior, where myelination occurs early in
      development. Myelin in these areas may be particularly vulnerable to prenatal
      substance exposure. FA and DR related moderately to cognitive function. Potential
      confounding factors existed and were considered.
FAU - Walhovd, K B
AU  - Walhovd KB
AD  - Department of Psychology, Center for the Study of Human Cognition, University of 
      Oslo, Oslo, Norway. k.b.walhovd@psykologi.uio.no
FAU - Westlye, L T
AU  - Westlye LT
FAU - Moe, V
AU  - Moe V
FAU - Slinning, K
AU  - Slinning K
FAU - Due-Tonnessen, P
AU  - Due-Tonnessen P
FAU - Bjornerud, A
AU  - Bjornerud A
FAU - van der Kouwe, A
AU  - van der Kouwe A
FAU - Dale, A M
AU  - Dale AM
FAU - Fjell, A M
AU  - Fjell AM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100304
PL  - United States
TA  - AJNR Am J Neuroradiol
JT  - AJNR. American journal of neuroradiology
JID - 8003708
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Cognition Disorders/*diagnosis/*etiology
MH  - Diffusion Magnetic Resonance Imaging/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Nerve Fibers, Myelinated/*pathology
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*diagnosis
MH  - Substance-Related Disorders/*complications/*diagnosis
PMC - PMC7964196
EDAT- 2010/03/06 06:00
MHDA- 2010/09/15 06:00
CRDT- 2010/03/06 06:00
PHST- 2010/03/06 06:00 [entrez]
PHST- 2010/03/06 06:00 [pubmed]
PHST- 2010/09/15 06:00 [medline]
AID - ajnr.A1957 [pii]
AID - 10.3174/ajnr.A1957 [doi]
PST - ppublish
SO  - AJNR Am J Neuroradiol. 2010 May;31(5):894-900. doi: 10.3174/ajnr.A1957. Epub 2010
      Mar 4.


PMID- 20203093
OWN - NLM
STAT- MEDLINE
DCOM- 20100505
LR  - 20111117
IS  - 1538-6724 (Electronic)
IS  - 0031-9023 (Linking)
VI  - 90
IP  - 4
DP  - 2010 Apr
TI  - Qualitative research ethics: enhancing evidence-based practice in physical
      therapy.
PG  - 615-28
LID - 10.2522/ptj.20080388 [doi]
AB  - BACKGROUND: Increasing challenges to health care systems and the prominence of
      patient-centered care and evidence-based practice have fostered the application
      of qualitative approaches in health care settings, prompting discussions of
      associated ethical issues in a range of disciplines. OBJECTIVES: The purposes of 
      this work were to identify and describe the application and value of qualitative 
      health research for physical therapy and to identify ethical considerations in a 
      qualitative research study. DESIGN: This was a qualitative interview study with
      telephone follow-ups. METHODS: Forty-six participants were interviewed about
      their early experiences with rheumatoid arthritis. They also were asked what
      motivated them to volunteer for the study. To inform the discussion of ethics in 
      qualitative health research, this study drew on the in-depth interviews, took a
      descriptive approach to the data, and applied the traditional ethical principles 
      of autonomy, justice, and beneficence to the study process. RESULTS: Ethical
      issues emerged in this qualitative health research study that were both similar
      to and different from those that exist in a positivist paradigm (eg, clinical
      research). With flexibility and latitude, the traditional principle approach can 
      be applied usefully to qualitative health research. CONCLUSIONS: These findings
      build on previous research and discussion in physical therapy and other
      disciplines that urge a flexible approach to qualitative research ethics and
      recognize that ethics are embedded in an unfolding research process involving the
      role of the subjective researcher and an active participant. We suggest
      reflexivity as a way to recognize ethical moments throughout qualitative research
      and to help build methodological and ethical rigor in research relevant to
      physical therapist practice.
FAU - Townsend, Anne
AU  - Townsend A
AD  - The W Maurice Young Centre for Applied Ethics, University of British Columbia,
      235-6356 Agricultural Rd, Klinck Building, Vancouver, British Columbia, Canada.
      atownsen@interchange.ubc.ca
FAU - Cox, Susan M
AU  - Cox SM
FAU - Li, Linda C
AU  - Li LC
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100304
PL  - United States
TA  - Phys Ther
JT  - Physical therapy
JID - 0022623
SB  - IM
MH  - Arthritis, Rheumatoid
MH  - *Beneficence
MH  - *Ethics, Research
MH  - Evidence-Based Practice
MH  - Humans
MH  - Interviews as Topic
MH  - Models, Theoretical
MH  - Patient Selection
MH  - *Personal Autonomy
MH  - Physical Therapy Specialty
MH  - Pilot Projects
MH  - *Qualitative Research
MH  - *Social Justice
EDAT- 2010/03/06 06:00
MHDA- 2010/05/06 06:00
CRDT- 2010/03/06 06:00
PHST- 2010/03/06 06:00 [entrez]
PHST- 2010/03/06 06:00 [pubmed]
PHST- 2010/05/06 06:00 [medline]
AID - ptj.20080388 [pii]
AID - 10.2522/ptj.20080388 [doi]
PST - ppublish
SO  - Phys Ther. 2010 Apr;90(4):615-28. doi: 10.2522/ptj.20080388. Epub 2010 Mar 4.


PMID- 20202949
OWN - NLM
STAT- MEDLINE
DCOM- 20100406
LR  - 20220317
IS  - 1931-3543 (Electronic)
IS  - 0012-3692 (Linking)
VI  - 137
IP  - 3
DP  - 2010 Mar
TI  - American College of Chest Physicians consensus statement on the management of
      dyspnea in patients with advanced lung or heart disease.
PG  - 674-91
LID - 10.1378/chest.09-1543 [doi]
AB  - BACKGROUND: This consensus statement was developed based on the understanding
      that patients with advanced lung or heart disease are not being treated
      consistently and effectively for relief of dyspnea. METHODS: A panel of experts
      was convened. After a literature review, the panel developed 23 statements
      covering five domains that were considered relevant to the topic condition.
      Endorsement of these statements was assessed by levels of agreement or
      disagreement on a five-point Likert scale using two rounds of the Delphi method. 
      RESULTS: The panel defined the topic condition as "dyspnea that persists at rest 
      or with minimal activity and is distressful despite optimal therapy of advanced
      lung or heart disease." The five domains were: measurement of patient-reported
      dyspnea, oxygen therapy, other therapies, opioid medications, and ethical issues.
      In the second round of the Delphi method, 34 of 56 individuals (61%) responded,
      and agreement of at least 70% was achieved for 20 of the 23 statements.
      CONCLUSIONS: For patients with advanced lung or heart disease, we suggest that:
      health-care professionals are ethically obligated to treat dyspnea, patients
      should be asked to rate the intensity of their breathlessness as part of a
      comprehensive care plan, opioids should be dosed and titrated for relief of
      dyspnea in the individual patient, both the patient and clinician should reassess
      whether specific treatments are serving the goal of palliating dyspnea without
      causing adverse effects, and it is important for clinicians to communicate about 
      palliative and end-of-life care with their patients.
FAU - Mahler, Donald A
AU  - Mahler DA
AD  - Dartmouth-Hitchcock Medical Center, Pulmonary and Critical Care Medicine,
      Lebanon, NH 03756-0001, USA. Donald.A.Mahler@Hitchcock.org
FAU - Selecky, Paul A
AU  - Selecky PA
FAU - Harrod, Christopher G
AU  - Harrod CG
FAU - Benditt, Joshua O
AU  - Benditt JO
FAU - Carrieri-Kohlman, Virginia
AU  - Carrieri-Kohlman V
FAU - Curtis, J Randall
AU  - Curtis JR
FAU - Manning, Harold L
AU  - Manning HL
FAU - Mularski, Richard A
AU  - Mularski RA
FAU - Varkey, Basil
AU  - Varkey B
FAU - Campbell, Margaret
AU  - Campbell M
FAU - Carter, Edward R
AU  - Carter ER
FAU - Chiong, Jun Ratunil
AU  - Chiong JR
FAU - Ely, E Wesley
AU  - Ely EW
FAU - Hansen-Flaschen, John
AU  - Hansen-Flaschen J
FAU - O'Donnell, Denis E
AU  - O'Donnell DE
FAU - Waller, Alexander
AU  - Waller A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Chest
JT  - Chest
JID - 0231335
SB  - IM
MH  - Clinical Competence
MH  - *Consensus
MH  - *Disease Management
MH  - Dyspnea/etiology/*therapy
MH  - Heart Diseases/*complications
MH  - Humans
MH  - Lung Diseases/*complications
MH  - *Practice Guidelines as Topic
MH  - United States
RF  - 103
EDAT- 2010/03/06 06:00
MHDA- 2010/04/07 06:00
CRDT- 2010/03/06 06:00
PHST- 2010/03/06 06:00 [entrez]
PHST- 2010/03/06 06:00 [pubmed]
PHST- 2010/04/07 06:00 [medline]
AID - S0012-3692(10)60147-X [pii]
AID - 10.1378/chest.09-1543 [doi]
PST - ppublish
SO  - Chest. 2010 Mar;137(3):674-91. doi: 10.1378/chest.09-1543.


PMID- 20202634
OWN - NLM
STAT- MEDLINE
DCOM- 20101026
LR  - 20161125
IS  - 1879-1484 (Electronic)
IS  - 0021-9150 (Linking)
VI  - 211
IP  - 1
DP  - 2010 Jul
TI  - What is the natural history of 18F-FDG uptake in arterial atheroma on PET/CT?
      Implications for imaging the vulnerable plaque.
PG  - 136-40
LID - 10.1016/j.atherosclerosis.2010.01.012 [doi]
AB  - PURPOSE: Increased uptake of 18F-fluorodeoxyglucose (18F-FDG) in atherosclerotic 
      plaque on Positron Emission Tomography (PET), predicts vulnerability. Recent
      studies have shown that the PET signal is reproducible over a 2-week period and
      as a result drug trials are underway. However, the natural history of these
      lesions is unknown. The aim of this study is determine the natural history of
      increased vascular wall uptake of 18F-fluorodeoxyglucose (18F-FDG). METHODS:
      Following institutional ethics committee approval, we retrospectively examined
      PET/CT images of patients from our Institution that had at least 4 examinations
      in the last 5 years. This represented 205 studies in total, from 50 patients (29 
      men, 21 women, mean age 49.4+/-12.1 years, mean 5.1+/-1.7 studies/patient). The
      mean follow-up was 27.2+/-11.8 months. The carotids and the aorta were evaluated 
      for increased 18F-FDG uptake with a maximum Standardized Uptake Value
      (SUVmax)>2.5, and >3.0, and calcification. Plots of SUVmax and Hounsfield units
      (HU) were made versus time. RESULTS: The initial prevalence of increased focal
      arterial 18F-FDG uptake was 17/50 patients and of arterial calcification 19/50.
      132 sites of 18F-FDG uptake in total were observed longitudinally. 18F-FDG
      vascular uptake did not persist with time. There was no correlation between
      18F-FDG uptake and HU. No calcifications developed at sites of focal increased
      18F-FDG uptake. CONCLUSIONS: Arterial lesions with increased 18F-FDG uptake
      represent transient phenomena. This data is important for the interpretation of
      findings of clinical trials using arterial 18F-FDG uptake as an imaging biomarker
      to monitor pharmacological intervention.
CI  - Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Menezes, Leon J
AU  - Menezes LJ
AD  - Institute of Nuclear Medicine, University College London and University College
      London Hospital, London, UK. leon@doctors.net.uk
FAU - Kayani, Irfan
AU  - Kayani I
FAU - Ben-Haim, Simona
AU  - Ben-Haim S
FAU - Hutton, Brian
AU  - Hutton B
FAU - Ell, Peter J
AU  - Ell PJ
FAU - Groves, Ashley M
AU  - Groves AM
LA  - eng
GR  - Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100122
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
RN  - 0 (Radiopharmaceuticals)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Atherosclerosis/*diagnostic imaging
MH  - Calcinosis/diagnostic imaging
MH  - Female
MH  - *Fluorodeoxyglucose F18
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Positron-Emission Tomography/methods
MH  - *Radiopharmaceuticals
MH  - Retrospective Studies
MH  - Tomography, X-Ray Computed/methods
EDAT- 2010/03/06 06:00
MHDA- 2010/10/27 06:00
CRDT- 2010/03/06 06:00
PHST- 2009/10/01 00:00 [received]
PHST- 2010/01/01 00:00 [revised]
PHST- 2010/01/09 00:00 [accepted]
PHST- 2010/03/06 06:00 [entrez]
PHST- 2010/03/06 06:00 [pubmed]
PHST- 2010/10/27 06:00 [medline]
AID - S0021-9150(10)00058-4 [pii]
AID - 10.1016/j.atherosclerosis.2010.01.012 [doi]
PST - ppublish
SO  - Atherosclerosis. 2010 Jul;211(1):136-40. doi:
      10.1016/j.atherosclerosis.2010.01.012. Epub 2010 Jan 22.


PMID- 20202504
OWN - NLM
STAT- MEDLINE
DCOM- 20100614
LR  - 20100305
IS  - 1557-9875 (Electronic)
IS  - 0733-8619 (Linking)
VI  - 28
IP  - 2
DP  - 2010 May
TI  - Consent issues in neurology.
PG  - 459-73
LID - 10.1016/j.ncl.2009.11.007 [doi]
AB  - The requirement that doctors obtain valid consent from patients before providing 
      medical treatment has long been ingrained in both legal doctrine and medical
      ethics. We summarize the foundations of the informed consent doctrine and discuss
      the recent evolution in thinking about consent and medical decision making. We
      show how consent has evolved from physicians merely providing patients
      information to shared decision making between patients and physicians. We then
      address three specific examples of situations common in neurological practice
      that pose challenges in obtaining valid consent: the administration of
      intravenous tPA following ischemic stroke, consideration of carotid
      endarterectomy for carotid artery stenosis, and implementation of
      do-not-resuscitate orders.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Rubin, Emily B
AU  - Rubin EB
AD  - Departments of Internal Medicine and Pediatrics, Massachusetts General Hospital, 
      55 Fruit Street, Boston, MA 02114, USA. emmyrubin@gmail.com
FAU - Bernat, James L
AU  - Bernat JL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Neurol Clin
JT  - Neurologic clinics
JID - 8219232
SB  - IM
MH  - Decision Making
MH  - *Ethics, Medical
MH  - Humans
MH  - Informed Consent/*legislation & jurisprudence/*standards
MH  - Neurology/*legislation & jurisprudence
EDAT- 2010/03/06 06:00
MHDA- 2010/06/15 06:00
CRDT- 2010/03/06 06:00
PHST- 2010/03/06 06:00 [entrez]
PHST- 2010/03/06 06:00 [pubmed]
PHST- 2010/06/15 06:00 [medline]
AID - S0733-8619(09)00115-7 [pii]
AID - 10.1016/j.ncl.2009.11.007 [doi]
PST - ppublish
SO  - Neurol Clin. 2010 May;28(2):459-73. doi: 10.1016/j.ncl.2009.11.007.


PMID- 20201766
OWN - NLM
STAT- MEDLINE
DCOM- 20100413
LR  - 20210501
IS  - 0025-729X (Print)
IS  - 0025-729X (Linking)
VI  - 192
IP  - 5
DP  - 2010 Mar 1
TI  - A case study evaluation of ethics review systems for multicentre clinical trials.
PG  - 292
FAU - Shelby-James, Tania
AU  - Shelby-James T
FAU - Agar, Meera R
AU  - Agar MR
FAU - Currow, David C
AU  - Currow DC
LA  - eng
PT  - Comment
PT  - Letter
PL  - Australia
TA  - Med J Aust
JT  - The Medical journal of Australia
JID - 0400714
SB  - IM
CON - Med J Aust. 2009 Sep 7;191(5):280-2. PMID: 19740053
MH  - Clinical Trials as Topic/ethics
MH  - *Ethical Review/economics
MH  - *Ethics Committees, Clinical
MH  - *Ethics, Medical
MH  - Humans
MH  - Multicenter Studies as Topic/economics/*ethics
MH  - New South Wales
MH  - Palliative Care
EDAT- 2010/03/06 06:00
MHDA- 2010/04/14 06:00
CRDT- 2010/03/06 06:00
PHST- 2009/10/13 00:00 [received]
PHST- 2009/12/20 00:00 [accepted]
PHST- 2010/03/06 06:00 [entrez]
PHST- 2010/03/06 06:00 [pubmed]
PHST- 2010/04/14 06:00 [medline]
AID - letters_010310_fm-2 [pii]
AID - 10.5694/j.1326-5377.2010.tb03514.x [doi]
PST - ppublish
SO  - Med J Aust. 2010 Mar 1;192(5):292. doi: 10.5694/j.1326-5377.2010.tb03514.x.


PMID- 20201762
OWN - NLM
STAT- MEDLINE
DCOM- 20100413
LR  - 20211203
IS  - 0025-729X (Print)
IS  - 0025-729X (Linking)
VI  - 192
IP  - 5
DP  - 2010 Mar 1
TI  - Ethics review of multisite studies: the difficult case of community-based
      indigenous health research.
PG  - 275-80
AB  - Researchers have longstanding concerns about the logistical and administrative
      burdens posed by ethics review of multisite studies involving human participants.
      Centralised ethics review, in which approval by one committee has authority
      across multiple sites, is widely touted as a strategy for streamlining the
      process. The Harmonisation of Multi-centre Ethical Review (HoMER) project is
      currently developing such a system for Australia. It is unclear how centralised
      review will work for multisite Indigenous health research, where the views of
      local stakeholders are important and community consultation is mandatory. Our
      recent experience in conducting the National Indigenous Eye Health Survey (NIEHS)
      shows how elaborate the current ethics approval and community consultation
      processes can be, and points to several lessons and ideas to guide pending
      reforms.
FAU - Studdert, David M
AU  - Studdert DM
AD  - Melbourne School of Population Health, University of Melbourne, Melbourne, VIC,
      Australia. d.studdert@unimelb.edu.au
FAU - Vu, Tamara M
AU  - Vu TM
FAU - Fox, Sarah S
AU  - Fox SS
FAU - Anderson, Ian P
AU  - Anderson IP
FAU - Keeffe, Jill E
AU  - Keeffe JE
FAU - Taylor, Hugh R
AU  - Taylor HR
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Med J Aust
JT  - The Medical journal of Australia
JID - 0400714
SB  - IM
MH  - Australia
MH  - Community-Based Participatory Research/ethics
MH  - *Ethical Review
MH  - Ethics Consultation/organization & administration
MH  - *Ethics, Research
MH  - *Health Surveys
MH  - Humans
MH  - Multicenter Studies as Topic/*ethics
MH  - *Native Hawaiian or Other Pacific Islander
EDAT- 2010/03/06 06:00
MHDA- 2010/04/14 06:00
CRDT- 2010/03/06 06:00
PHST- 2009/07/29 00:00 [received]
PHST- 2009/10/05 00:00 [accepted]
PHST- 2010/03/06 06:00 [entrez]
PHST- 2010/03/06 06:00 [pubmed]
PHST- 2010/04/14 06:00 [medline]
AID - stu10907_fm [pii]
AID - 10.5694/j.1326-5377.2010.tb03508.x [doi]
PST - ppublish
SO  - Med J Aust. 2010 Mar 1;192(5):275-80. doi: 10.5694/j.1326-5377.2010.tb03508.x.


PMID- 20201624
OWN - NLM
STAT- MEDLINE
DCOM- 20100616
LR  - 20181201
IS  - 1473-4877 (Electronic)
IS  - 0300-7995 (Linking)
VI  - 26
IP  - 4
DP  - 2010 Apr
TI  - Efficacy of a comprehensive program for reducing stress in women: a prospective, 
      randomized trial.
PG  - 991-1002
LID - 10.1185/03007991003688193 [doi]
AB  - OBJECTIVE: This study evaluated the efficacy of a comprehensive stress management
      program in reducing perceived stress among women who reported moderate-to-high
      stress levels. METHODS: A total of 562 highly motivated females, aged 25-45, with
      moderate to high stress levels, were enrolled in a 14-week study. Participants
      were randomized into one of three groups: Group 1 included Internet-based
      coaching focusing on behavior modification, daily use of proprietary
      olfactive-based personal care products, and periodic feedback reports; Group 2
      consisted of only online coaching; and Group 3 had no active stress management
      program. Participants in the three groups filled out validated psychometric
      assessments at baseline and throughout the study period. Several outcomes
      including Perceived Stress Scale (PSS), Profile of Mood States (POMS), St Mary's 
      Hospital Sleep Questionnaire (SMS), the Trier Inventory of Chronic Stress (TICS),
      Spielberger State-Trait Anxiety Inventory (STAI), Short-Form-36 (SF-36) and the
      Work Productivity and Activity Impairment (WPAI), were measured periodically to
      assess changes in subject-perceived stress, stress-related comorbidities, and
      sleep quality and to evaluate overall program efficacy. Ethical approval of
      protocols was conducted by the Allendale Investigational Review Board (AIRB).
      Voluntary informed consent was obtained from each subject. RESULTS: At the end of
      the 14-week study period, subjects in Group 1 had statistically significant
      improvement in the PSS score vs. Group 3 (p < 0.01). There were statistically
      significant improvements in other efficacy outcomes such as POMS total mood
      disturbance, TICS work overload and social responsibility subscales, STAI and in 
      the number of night awakenings, assessed by the SMS questionnaire (p < 0.05).
      Self-reported program efficacy was also significantly higher for Group 1 (p <
      0.001). CONCLUSION: Despite study limitations, including reduction of stress in
      Group 3, this study demonstrates that this comprehensive stress management
      program is effective in reducing stress among women with moderate to high stress 
      levels.
FAU - Wiegand, Benjamin
AU  - Wiegand B
AD  - Wellness & Prevention, Inc., a Johnson & Johnson Company, Ft. Washington, PA
      19034, USA. bwiegan@its.jnj.com
FAU - Luedtke, Kathryn
AU  - Luedtke K
FAU - Friscia, Diana
AU  - Friscia D
FAU - Nair, Mona
AU  - Nair M
FAU - Aleles, Margaret
AU  - Aleles M
FAU - McCloskey, Richard
AU  - McCloskey R
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Curr Med Res Opin
JT  - Current medical research and opinion
JID - 0351014
SB  - IM
MH  - Activities of Daily Living
MH  - Adult
MH  - *Aromatherapy
MH  - *Behavior Therapy
MH  - Cognitive Behavioral Therapy
MH  - Comprehensive Health Care
MH  - Female
MH  - Humans
MH  - Internet
MH  - Middle Aged
MH  - Prospective Studies
MH  - Relaxation Therapy
MH  - Sleep Wake Disorders/prevention & control
MH  - Stress, Psychological/*therapy
MH  - *Telemedicine
MH  - United States
EDAT- 2010/03/06 06:00
MHDA- 2010/06/17 06:00
CRDT- 2010/03/06 06:00
PHST- 2010/03/06 06:00 [entrez]
PHST- 2010/03/06 06:00 [pubmed]
PHST- 2010/06/17 06:00 [medline]
AID - 10.1185/03007991003688193 [doi]
PST - ppublish
SO  - Curr Med Res Opin. 2010 Apr;26(4):991-1002. doi: 10.1185/03007991003688193.


PMID- 20201052
OWN - NLM
STAT- MEDLINE
DCOM- 20110120
LR  - 20100929
IS  - 1098-2752 (Electronic)
IS  - 0738-1085 (Linking)
VI  - 30
IP  - 6
DP  - 2010 Sep
TI  - Assessing suturing techniques using a virtual reality surgical simulator.
PG  - 479-86
LID - 10.1002/micr.20766 [doi]
AB  - Advantages of virtual-reality simulators surgical skill assessment and training
      include more training time, no risk to patient, repeatable difficulty level,
      reliable feedback, without the resource demands, and ethical issues of
      animal-based training. We tested this for a key subtask and showed a strong link 
      between skill in the simulator and in reality. Suturing performance was assessed 
      for four groups of participants, including experienced surgeons and naive
      subjects, on a custom-made virtual-reality simulator. Each subject tried the
      experiment 30 times using five different types of needles to perform a
      standardized suture placement task. Traditional metrics of performance as well as
      new metrics enabled by our system were proposed, and the data indicate difference
      between trained and untrained performance. In all traditional parameters such as 
      time, number of attempts, and motion quantity, the medical surgeons outperformed 
      the other three groups, though differences were not significant. However, motion 
      smoothness, penetration and exit angles, tear size areas, and orientation change 
      were statistically significant in the trained group when compared with untrained 
      group. This suggests that these parameters can be used in virtual microsurgery
      training.
FAU - Kazemi, Hamed
AU  - Kazemi H
AD  - Department of Mechanical Engineering, National University of Singapore,
      Singapore.
FAU - Rappel, James K
AU  - Rappel JK
FAU - Poston, Timothy
AU  - Poston T
FAU - Hai Lim, Beng
AU  - Hai Lim B
FAU - Burdet, Etienne
AU  - Burdet E
FAU - Leong Teo, Chee
AU  - Leong Teo C
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Microsurgery
JT  - Microsurgery
JID - 8309230
SB  - IM
MH  - Adult
MH  - Clinical Competence
MH  - Equipment Design
MH  - Humans
MH  - Male
MH  - Microsurgery/*education
MH  - Models, Educational
MH  - Needles
MH  - *Suture Techniques
MH  - *Task Performance and Analysis
MH  - Time and Motion Studies
MH  - User-Computer Interface
MH  - Young Adult
EDAT- 2010/03/05 06:00
MHDA- 2011/01/21 06:00
CRDT- 2010/03/05 06:00
PHST- 2010/03/05 06:00 [entrez]
PHST- 2010/03/05 06:00 [pubmed]
PHST- 2011/01/21 06:00 [medline]
AID - 10.1002/micr.20766 [doi]
PST - ppublish
SO  - Microsurgery. 2010 Sep;30(6):479-86. doi: 10.1002/micr.20766.


PMID- 20200777
OWN - NLM
STAT- MEDLINE
DCOM- 20100708
LR  - 20220331
IS  - 0037-5675 (Print)
IS  - 0037-5675 (Linking)
VI  - 51
IP  - 1
DP  - 2010 Jan
TI  - Diabetic retinopathy in a Nigerian community.
PG  - 56-9
AB  - INTRODUCTION: This study was designed to determine the prevalence of diabetic
      retinopathy among diabetic patients attending the medical outpatient department
      of the Federal Medical Centre, Owo, Ondo State, Nigeria. METHODS: This study was 
      conducted between November 2007 and February 2008. Ethical clearance was obtained
      from the ethical committee of the hospital prior to carrying out the study. 100
      diabetic patients selected by simple random sampling were interviewed with the
      aid of a semi-structured questionnaire. All the respondents had fundoscopy
      conducted at the eye clinic with the aid of a direct ophthalmoscope. The data was
      collated and analysed. RESULTS: The majority of the respondents (85 percent) had 
      type 2 diabetes mellitus, while the rest (15 percent) had type 1 diabetes
      mellitus. 15 percent of the respondents had varying degrees of diabetic
      retinopathy. The duration of diabetes mellitus was significantly associated with 
      the development of diabetic retinopathy at a p-value of 0.002. CONCLUSION: A few 
      of the respondents had diabetic retinopathy. There is a need to create awareness 
      among diabetic patients on the need for routine ocular examinations.
FAU - Omolase, C O
AU  - Omolase CO
AD  - Department of Ophthalmology, Federal Medical Centre, PMB 1053, Owo, Ondo State,
      Nigeria. omolash2000@yahoo.com
FAU - Adekanle, O
AU  - Adekanle O
FAU - Owoeye, J F A
AU  - Owoeye JF
FAU - Omolase, B O
AU  - Omolase BO
LA  - eng
PT  - Journal Article
PL  - Singapore
TA  - Singapore Med J
JT  - Singapore medical journal
JID - 0404516
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 1/*complications/epidemiology
MH  - Diabetes Mellitus, Type 2/*complications/epidemiology
MH  - Diabetic Retinopathy/*epidemiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nigeria/epidemiology
MH  - Outpatient Clinics, Hospital/statistics & numerical data
MH  - *Population Surveillance
MH  - Prevalence
MH  - Young Adult
EDAT- 2010/03/05 06:00
MHDA- 2010/07/09 06:00
CRDT- 2010/03/05 06:00
PHST- 2010/03/05 06:00 [entrez]
PHST- 2010/03/05 06:00 [pubmed]
PHST- 2010/07/09 06:00 [medline]
PST - ppublish
SO  - Singapore Med J. 2010 Jan;51(1):56-9.


PMID- 20200522
OWN - NLM
STAT- MEDLINE
DCOM- 20100526
LR  - 20191210
IS  - 1745-655X (Electronic)
IS  - 0197-5897 (Linking)
VI  - 31
IP  - 1
DP  - 2010 Apr
TI  - Commentary: Understanding the origins of anger, contempt, and disgust in public
      health policy disputes: applying moral psychology to harm reduction debates.
PG  - 1-16
LID - 10.1057/jphp.2009.52 [doi]
AB  - Scientific disputes about public health issues can become emotional battlefields 
      marked by strong emotions like anger, contempt, and disgust. Contemporary work in
      moral psychology demonstrates that each of these emotions is a reaction to a
      specific type of moral violation. Applying this work to harm reduction debates,
      specifically the use of smokeless tobacco to reduce harm from tobacco use, we
      attempt to explain why some public health disputes have been so heated. Public
      health ethics tend to emphasize social justice concerns to the exclusion of other
      moral perspectives that value scientific authority, professional loyalty, and
      bodily purity. An awareness of their different emotional reactions and underlying
      moral motivations might help public health professionals better understand each
      others' viewpoints, ultimately leading to more productive dialogue.
FAU - Alderman, Jess
AU  - Alderman J
AD  - School of Public Health and Health Professions, University at Buffalo, SUNY,
      Buffalo, New York 14214-3079, USA.
FAU - Dollar, Katherine M
AU  - Dollar KM
FAU - Kozlowski, Lynn T
AU  - Kozlowski LT
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Public Health Policy
JT  - Journal of public health policy
JID - 8006508
SB  - IM
MH  - Affect
MH  - *Anger
MH  - Conflict, Psychological
MH  - *Harm Reduction
MH  - *Health Policy
MH  - Humans
MH  - Judgment
MH  - *Morals
MH  - *Public Health
MH  - Tobacco, Smokeless
EDAT- 2010/03/05 06:00
MHDA- 2010/05/27 06:00
CRDT- 2010/03/05 06:00
PHST- 2010/03/05 06:00 [entrez]
PHST- 2010/03/05 06:00 [pubmed]
PHST- 2010/05/27 06:00 [medline]
AID - jphp200952 [pii]
AID - 10.1057/jphp.2009.52 [doi]
PST - ppublish
SO  - J Public Health Policy. 2010 Apr;31(1):1-16. doi: 10.1057/jphp.2009.52.


PMID- 20200362
OWN - NLM
STAT- MEDLINE
DCOM- 20100323
LR  - 20100318
IS  - 1533-4406 (Electronic)
IS  - 0028-4793 (Linking)
VI  - 362
IP  - 11
DP  - 2010 Mar 18
TI  - The Israeli field hospital in Haiti--ethical dilemmas in early disaster response.
PG  - e38
LID - 10.1056/NEJMp1001693 [doi]
FAU - Merin, Ofer
AU  - Merin O
AD  - Trauma Unit and Department of Cardiothoracic Surgery, Shaare Zedek Medical
      Center, and Hebrew University Faculty of Medicine, Jerusalem, Israel.
FAU - Ash, Nachman
AU  - Ash N
FAU - Levy, Gad
AU  - Levy G
FAU - Schwaber, Mitchell J
AU  - Schwaber MJ
FAU - Kreiss, Yitshak
AU  - Kreiss Y
LA  - eng
PT  - Journal Article
DEP - 20100303
PL  - United States
TA  - N Engl J Med
JT  - The New England journal of medicine
JID - 0255562
SB  - IM
MH  - Disaster Medicine/*ethics/organization & administration
MH  - *Disasters
MH  - *Earthquakes
MH  - Ethics, Medical
MH  - Female
MH  - Haiti
MH  - Humans
MH  - International Cooperation
MH  - Israel
MH  - Mobile Health Units/ethics/organization & administration
MH  - Relief Work/*ethics/organization & administration
MH  - Triage/*ethics/standards
EDAT- 2010/03/05 06:00
MHDA- 2010/03/24 06:00
CRDT- 2010/03/05 06:00
PHST- 2010/03/05 06:00 [entrez]
PHST- 2010/03/05 06:00 [pubmed]
PHST- 2010/03/24 06:00 [medline]
AID - NEJMp1001693 [pii]
AID - 10.1056/NEJMp1001693 [doi]
PST - ppublish
SO  - N Engl J Med. 2010 Mar 18;362(11):e38. doi: 10.1056/NEJMp1001693. Epub 2010 Mar
      3.


PMID- 20200180
OWN - NLM
STAT- MEDLINE
DCOM- 20100406
LR  - 20200611
IS  - 1758-1095 (Electronic)
IS  - 0141-0768 (Linking)
VI  - 103
IP  - 3
DP  - 2010 Mar
TI  - Medicolegal reports in asylum applications: a framework for addressing the
      practical and ethical challenges.
PG  - 93-7
LID - 10.1258/jrsm.2010.090362 [doi]
AB  - The clinical care of asylum-seekers may bring clinicians in contact with the
      immigration authorities. A request for a medicolegal report usually requires the 
      responsible clinician to state their opinion on the risks involved in returning
      an applicant to their country of origin, taking into account their current
      condition, the treatments available in that country, and the risks involved in
      travel. This review draws on clinical experience and a review of the literature
      to describe the work involved in preparing a medical report requested by
      immigration authorities. Although the starting point chosen is the psychiatric
      report, the principles described apply to the preparation of immigration reports 
      in any medical discipline.
FAU - Pitman, Alexandra
AU  - Pitman A
AD  - Department of Mental Health Sciences, UCL Medical School - Royal Free Campus
      Rowland Hill Street, London NW3 2PF, UK. a.pitman@medsch.ucl.ac.uk
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J R Soc Med
JT  - Journal of the Royal Society of Medicine
JID - 7802879
SB  - IM
MH  - *Emigration and Immigration
MH  - *Ethics, Medical
MH  - Gatekeeping/*organization & administration
MH  - Health Services Accessibility
MH  - *Health Status
MH  - Humans
MH  - Medical Records/*legislation & jurisprudence
MH  - *Refugees
MH  - United Kingdom
RF  - 15
PMC - PMC3072262
EDAT- 2010/03/05 06:00
MHDA- 2010/04/07 06:00
CRDT- 2010/03/05 06:00
PHST- 2010/03/05 06:00 [entrez]
PHST- 2010/03/05 06:00 [pubmed]
PHST- 2010/04/07 06:00 [medline]
AID - 103/3/93 [pii]
AID - 10.1258/jrsm.2010.090362 [doi]
PST - ppublish
SO  - J R Soc Med. 2010 Mar;103(3):93-7. doi: 10.1258/jrsm.2010.090362.


PMID- 20199699
OWN - NLM
STAT- MEDLINE
DCOM- 20110112
LR  - 20181201
IS  - 1741-203X (Electronic)
IS  - 1041-6102 (Linking)
VI  - 22
IP  - 7
DP  - 2010 Nov
TI  - Ethical and practical concerns of surveillance technologies in residential care
      for people with dementia or intellectual disabilities: an overview of the
      literature.
PG  - 1129-42
LID - 10.1017/S1041610210000037 [doi]
AB  - BACKGROUND: Technology has emerged as a potential solution to alleviate some of
      the pressures on an already overburdened care system, thereby meeting the growing
      needs of an expanding population of seriously cognitively impaired people.
      However, questions arise as to what extent technologies are already being used in
      residential care and how ethically and practically acceptable this use would be. 
      METHODS: A systematic literature review was conducted to explore what is known on
      the moral and practical acceptability of surveillance technologies in residential
      care for people with dementia or intellectual disabilities, and to set forth the 
      state of the debate. RESULTS: A total of 79 papers met the inclusion criteria.
      The findings show that application and use of surveillance technologies in
      residential care for vulnerable people generates considerable ethical debate.
      This ethical debate centers not so much around the effects of technology, but
      rather around the moral acceptability of those effects, especially when a
      conflict arises between the interests of the institution and the interests of the
      resident. However, the majority of articles lack in depth analysis. Furthermore, 
      there are notable cultural differences between the European literature and
      American literature whereby in Britain there seems to be more ethical debate than
      in America. Overall however, there is little attention for the resident
      perspective. CONCLUSION: No ethical consensus has yet been reached, underlining
      the need for clear(er) policies. More research is thus recommended to determine
      ethical and practical viability of surveillance technologies whereby research
      should be specifically focused on the resident perspective.
FAU - Niemeijer, Alistair R
AU  - Niemeijer AR
AD  - Department of Nursing Home Medicine/ EMGO Institute for Health and Care Research,
      VU University Medical Center, Amsterdam, The Netherlands. a.niemeijer@vumc.nl
FAU - Frederiks, Brenda J M
AU  - Frederiks BJ
FAU - Riphagen, Ingrid I
AU  - Riphagen II
FAU - Legemaate, Johan
AU  - Legemaate J
FAU - Eefsting, Jan A
AU  - Eefsting JA
FAU - Hertogh, Cees M P M
AU  - Hertogh CM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20100304
PL  - England
TA  - Int Psychogeriatr
JT  - International psychogeriatrics
JID - 9007918
SB  - IM
MH  - Delivery of Health Care/ethics
MH  - Dementia/*psychology
MH  - Emergency Medical Tags/*ethics
MH  - Humans
MH  - Intellectual Disability/*psychology
MH  - Residential Facilities
MH  - Safety Management/ethics
MH  - Security Measures
MH  - Technology/*ethics
EDAT- 2010/03/05 06:00
MHDA- 2011/01/13 06:00
CRDT- 2010/03/05 06:00
PHST- 2010/03/05 06:00 [entrez]
PHST- 2010/03/05 06:00 [pubmed]
PHST- 2011/01/13 06:00 [medline]
AID - S1041610210000037 [pii]
AID - 10.1017/S1041610210000037 [doi]
PST - ppublish
SO  - Int Psychogeriatr. 2010 Nov;22(7):1129-42. doi: 10.1017/S1041610210000037. Epub
      2010 Mar 4.


PMID- 20199669
OWN - NLM
STAT- MEDLINE
DCOM- 20100503
LR  - 20211020
IS  - 1746-6148 (Electronic)
IS  - 1746-6148 (Linking)
VI  - 6
DP  - 2010 Mar 3
TI  - A survey of castration methods and associated livestock management practices
      performed by bovine veterinarians in the United States.
PG  - 12
LID - 10.1186/1746-6148-6-12 [doi]
AB  - BACKGROUND: Castration of male calves destined for beef production is a common
      management practice performed in the United States amounting to approximately 15 
      million procedures per year. Societal concern about the moral and ethical
      treatment of animals is increasing. Therefore, production agriculture is faced
      with the challenge of formulating animal welfare policies relating to routine
      management practices such as castration. To enable the livestock industry to
      effectively respond to these challenges there is a need for more data on
      management practices that are commonly used in cattle production systems. The
      objective of this survey was to describe castration methods, adverse events and
      husbandry procedures performed by U.S. veterinarians at the time of castration.
      Invitations to participate in the survey were sent to email addresses of 1,669
      members of the American Association of Bovine Practitioners and 303 members of
      the Academy of Veterinary Consultants. RESULTS: After partially completed surveys
      and missing data were omitted, 189 responses were included in the analysis.
      Surgical castration with a scalpel followed by testicular removal by twisting
      (calves <90 kg) or an emasculator (calves >90 kg) was the most common method of
      castration used. The potential risk of injury to the operator, size of the calf, 
      handling facilities and experience with the technique were the most important
      considerations used to determine the method of castration used. Swelling,
      stiffness and increased lying time were the most prevalent adverse events
      observed following castration. One in five practitioners report using an
      analgesic or local anesthetic at the time of castration. Approximately 90% of
      respondents indicated that they vaccinate and dehorn calves at the time of
      castration. Over half the respondents use disinfectants, prophylactic
      antimicrobials and tetanus toxoid to reduce complications following castration.
      CONCLUSIONS: The results of this survey describe current methods of castration
      and associated management practices employed by bovine veterinarians in the U.S. 
      Such data are needed to guide future animal well-being research, the outcomes of 
      which can be used to develop industry-relevant welfare guidelines.
FAU - Coetzee, Johann F
AU  - Coetzee JF
AD  - Department of Clinical Sciences, College of Veterinary Medicine, Kansas State
      University, Manhattan, KS 66506-5601, USA. jcoetzee@vet.ksu.edu
FAU - Nutsch, Abbey L
AU  - Nutsch AL
FAU - Barbur, Laura A
AU  - Barbur LA
FAU - Bradburn, Ryan M
AU  - Bradburn RM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20100303
PL  - England
TA  - BMC Vet Res
JT  - BMC veterinary research
JID - 101249759
RN  - 0 (Analgesics)
RN  - 0 (Anesthetics, Local)
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Tetanus Toxoid)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Analgesics/administration & dosage
MH  - Anesthetics, Local/administration & dosage
MH  - Animal Husbandry/*methods
MH  - Animal Welfare
MH  - Animals
MH  - Anti-Infective Agents/administration & dosage
MH  - Cattle
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Orchiectomy/adverse effects/methods/*veterinary
MH  - Surveys and Questionnaires
MH  - Tetanus Toxoid/administration & dosage
MH  - United States
MH  - Vaccination/veterinary
MH  - Veterinary Medicine/*methods/statistics & numerical data
MH  - Young Adult
PMC - PMC2841153
EDAT- 2010/03/05 06:00
MHDA- 2010/05/04 06:00
CRDT- 2010/03/05 06:00
PHST- 2009/10/12 00:00 [received]
PHST- 2010/03/03 00:00 [accepted]
PHST- 2010/03/05 06:00 [entrez]
PHST- 2010/03/05 06:00 [pubmed]
PHST- 2010/05/04 06:00 [medline]
AID - 1746-6148-6-12 [pii]
AID - 10.1186/1746-6148-6-12 [doi]
PST - epublish
SO  - BMC Vet Res. 2010 Mar 3;6:12. doi: 10.1186/1746-6148-6-12.


PMID- 20199003
OWN - NLM
STAT- MEDLINE
DCOM- 20100401
LR  - 20220317
IS  - 0954-7762 (Print)
IS  - 0954-7762 (Linking)
VI  - 106
IP  - 4
DP  - 2010 Feb 2-8
TI  - Whistleblowing: what influences nurses' decisions on whether to report poor
      practice?
PG  - 22-5
AB  - Several recent high profile examples demonstrate that nurses fear and have reason
      to fear the consequences of reporting poor practice. This article examines the
      ethical issues surrounding whistleblowing, discussing in detail the reasons for
      and against reporting concerns about poor practice, and how nurses can be
      supported to do this.
FAU - Gallagher, Ann
AU  - Gallagher A
AD  - International Centre for Nursing Ethics, University of Surrey.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Times
JT  - Nursing times
JID - 0423236
MH  - Awareness
MH  - Codes of Ethics/classification
MH  - Decision Making
MH  - *Ethics, Nursing
MH  - Female
MH  - Humans
MH  - Male
MH  - Nurse-Patient Relations
MH  - Social Justice
MH  - Social Responsibility
MH  - Whistleblowing/*ethics
EDAT- 2010/03/05 06:00
MHDA- 2010/04/02 06:00
CRDT- 2010/03/05 06:00
PHST- 2010/03/05 06:00 [entrez]
PHST- 2010/03/05 06:00 [pubmed]
PHST- 2010/04/02 06:00 [medline]
PST - ppublish
SO  - Nurs Times. 2010 Feb 2-8;106(4):22-5.


PMID- 20198741
OWN - NLM
STAT- MEDLINE
DCOM- 20100323
LR  - 20100303
IS  - 1546-3141 (Electronic)
IS  - 0361-803X (Linking)
VI  - 194
IP  - 3
DP  - 2010 Mar
TI  - Journal publication ethics 201: culture in crisis?
PG  - 553
FAU - Berquist, Thomas H
AU  - Berquist TH
LA  - eng
PT  - Editorial
PL  - United States
TA  - AJR Am J Roentgenol
JT  - AJR. American journal of roentgenology
JID - 7708173
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Culture
MH  - Editorial Policies
MH  - Peer Review, Research/ethics
MH  - Periodicals as Topic/*ethics
MH  - Publications/*ethics
MH  - Publishing/*ethics
MH  - *Radiology
MH  - Scientific Misconduct/*ethics
EDAT- 2010/03/05 06:00
MHDA- 2010/03/24 06:00
CRDT- 2010/03/05 06:00
PHST- 2010/03/05 06:00 [entrez]
PHST- 2010/03/05 06:00 [pubmed]
PHST- 2010/03/24 06:00 [medline]
AID - 10.2214/AJR.10.4352 [doi]
PST - ppublish
SO  - AJR Am J Roentgenol. 2010 Mar;194(3):553. doi: 10.2214/AJR.10.4352.


PMID- 20198564
OWN - NLM
STAT- MEDLINE
DCOM- 20110418
LR  - 20131121
IS  - 1439-4421 (Electronic)
IS  - 0941-3790 (Linking)
VI  - 72
IP  - 12
DP  - 2010 Dec
TI  - [Prevention of neural tube defects: regional policies in folic acid enrichment
      and supplementation].
PG  - 875-9
LID - 10.1055/s-0029-1246171 [doi]
AB  - BACKGROUND: The USA and Canada had already started an obligatory food
      fortification with folic acid in 1998; In 2009, Australia and New Zealand also
      started to do so. METHODS: A survey was carried out among members of The European
      Consumers' Organisation (BEUC). RESULTS: Most of the European countries go along 
      with the recommendation of 200 mug folic acid (or 400 mug folic acid equivalents)
      for adults and 300 mug (600 mug) for pregnant women. To prevent neural tube
      defects, an additional supplementation of 0,4 mg folic acid is recommended for
      women before conception. So far, none of the European countries has implemented
      an obligatory folic acid enrichment of grain or other food, but this step is
      under discussion. CONCLUSION: In a European market with free trading of goods it 
      is of utmost importance that especially those (socially deprived) women in most
      need of folic acid, are reached. A common European decision for/against
      fortification should be considered. Public Health ethics demand not only good
      evidence for the benefit, but also a good estimation of the (potential) risks.
      Due to a paucity of good risk estimation, no European country has plans to decide
      in favour of an obligatory fortification on its own.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Wild, C
AU  - Wild C
AD  - Ludwig Boltzmann Institut fur Health Technology Assessment, Wien, Osterreich.
      Claudia.wild@hta.lbg.ac.at
FAU - Lehner, P
AU  - Lehner P
FAU - Reiselhuber, S
AU  - Reiselhuber S
FAU - Schiller-Fruhwirth, I
AU  - Schiller-Fruhwirth I
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Pravention von Neuralrohrdefekten: Landerpolitiken zur Folsaureanreicherung und
      -supplementierung.
DEP - 20100302
PL  - Germany
TA  - Gesundheitswesen
JT  - Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes
      (Germany))
JID - 9204210
RN  - 12001-76-2 (Vitamin B Complex)
RN  - 935E97BOY8 (Folic Acid)
SB  - IM
MH  - Adult
MH  - Austria/epidemiology
MH  - Dietary Supplements
MH  - Female
MH  - Folic Acid/*administration & dosage
MH  - *Food, Fortified
MH  - *Health Policy
MH  - Humans
MH  - Male
MH  - Neural Tube Defects/*epidemiology/*prevention & control
MH  - Pregnancy
MH  - Prevalence
MH  - *Proportional Hazards Models
MH  - Regional Medical Programs/*organization & administration
MH  - Risk Assessment
MH  - Risk Factors
MH  - Vitamin B Complex/administration & dosage
EDAT- 2010/03/04 06:00
MHDA- 2011/04/19 06:00
CRDT- 2010/03/04 06:00
PHST- 2010/03/04 06:00 [entrez]
PHST- 2010/03/04 06:00 [pubmed]
PHST- 2011/04/19 06:00 [medline]
AID - 10.1055/s-0029-1246171 [doi]
PST - ppublish
SO  - Gesundheitswesen. 2010 Dec;72(12):875-9. doi: 10.1055/s-0029-1246171. Epub 2010
      Mar 2.


PMID- 20198519
OWN - NLM
STAT- MEDLINE
DCOM- 20100921
LR  - 20211020
IS  - 2629-3277 (Electronic)
IS  - 2629-3277 (Linking)
VI  - 6
IP  - 2
DP  - 2010 Jun
TI  - Ethical aspects of human embryonic stem cell research in the islamic world:
      positions and reflections.
PG  - 151-61
LID - 10.1007/s12015-010-9117-6 [doi]
AB  - Rapid technological developments in human embryonic stem cell research are
      holding promises of future new medical treatment for a range of currently
      incurable chronic diseases. At the same time, stem cell research using human
      embryos raises radically new, previously unimaginable ethical issues posing a
      dramatic challenge to humankind. By analysing the discourses on these ethical
      issues we can show that the cultural values and religious convictions of all
      stakeholders involved play a decisive role in formulating ethical positions. In
      the Islamic world, too, stem cell research using human embryos provokes new
      discussions about the moral status of the embryo according to Islamic ethical
      norms. In our paper we describe the theological and philosophical criteria used
      in this debate and discuss some ethical positions vis-a-vis embryonic stem cell
      research formulated in the Islamic world, including official regulations existing
      in some Muslim countries. While most of the existing literature in this field is 
      primarily descriptive, the present paper endeavours to examine not only the
      arguments and their historical conditions as such; in addition, we will for the
      first time provide a critical reflection on the methodology underlying commonly
      held positions. In our view, this reflection is of paramount importance in
      establishing a straightforward constructive dialogue between different cultures
      and academic disciplines.
FAU - Ilkilic, Ilhan
AU  - Ilkilic I
AD  - Institute for History, Philosophy and Ethics of Medicine, Johannes Gutenberg
      University Mainz Medical Center, Am Pulverturm 13, 55131, Mainz, Germany.
      ilkilic@uni-mainz.de
FAU - Ertin, Hakan
AU  - Ertin H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Stem Cell Rev Rep
JT  - Stem cell reviews and reports
JID - 101752767
SB  - IM
MH  - Biomedical Research/*ethics
MH  - *Embryonic Stem Cells
MH  - Humans
MH  - Islam
EDAT- 2010/03/04 06:00
MHDA- 2010/09/23 06:00
CRDT- 2010/03/04 06:00
PHST- 2010/03/04 06:00 [entrez]
PHST- 2010/03/04 06:00 [pubmed]
PHST- 2010/09/23 06:00 [medline]
AID - 10.1007/s12015-010-9117-6 [doi]
PST - ppublish
SO  - Stem Cell Rev Rep. 2010 Jun;6(2):151-61. doi: 10.1007/s12015-010-9117-6.


PMID- 20198516
OWN - NLM
STAT- MEDLINE
DCOM- 20100921
LR  - 20211020
IS  - 2629-3277 (Electronic)
IS  - 2629-3277 (Linking)
VI  - 6
IP  - 2
DP  - 2010 Jun
TI  - Stem cell research in the Greater Middle East: the importance of establishing
      policy and ethics interoperability to foster international collaborations.
PG  - 143-50
LID - 10.1007/s12015-010-9133-6 [doi]
AB  - While fossil fuel reserves have strengthened the economies of numerous countries 
      in the Greater Middle East (GME) for decades, multiple nations within this region
      are now increasingly investing in internal science and engineering programs as a 
      mechanism to develop more extensive knowledge-based economies. One of these newly
      pursued disciplines is stem cell research. Nations such as Saudi Arabia and Qatar
      have founded nascent programs while Iran, Turkey, and Israel are more established
      in the field. The extent to which these investments have been productive, as
      measured by publication quantity and impact, remains unknown. Here we assess the 
      state of stem cell research in the GME, report on the policy and ethical
      considerations facing the region, and determine the impact of international
      research collaborations in this area. In the majority of the region, there is no 
      legal framework regulating stem cell research. Instead, scientists often rely on 
      religious decrees outlining acceptable practices. These guidelines do not provide
      the necessary structure to foster international collaborations with nations that 
      have enacted formal laws recognized worldwide. Our results illustrate that
      international collaborations in the GME produce publications of greater impact
      despite the fact that political tensions and issues unrelated to science have the
      potential to dramatically hinder cross-border relationships in the region.
      Overall, we conclude that the national governments of countries within the GME
      have the unique opportunity to establish stem cell research policies which confer
      interoperability between nations to foster crucial international collaborations
      throughout the region.
FAU - Flynn, Jesse M
AU  - Flynn JM
AD  - Department of Biochemistry and Molecular Biology, The University of Texas M. D.
      Anderson Cancer Center, Houston, TX 77030, USA.
FAU - Matthews, Kirstin R W
AU  - Matthews KR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Stem Cell Rev Rep
JT  - Stem cell reviews and reports
JID - 101752767
SB  - IM
MH  - Biomedical Research/*ethics/*legislation & jurisprudence
MH  - International Cooperation
MH  - Middle East
MH  - *Stem Cells
EDAT- 2010/03/04 06:00
MHDA- 2010/09/23 06:00
CRDT- 2010/03/04 06:00
PHST- 2010/03/04 06:00 [entrez]
PHST- 2010/03/04 06:00 [pubmed]
PHST- 2010/09/23 06:00 [medline]
AID - 10.1007/s12015-010-9133-6 [doi]
PST - ppublish
SO  - Stem Cell Rev Rep. 2010 Jun;6(2):143-50. doi: 10.1007/s12015-010-9133-6.


PMID- 20197514
OWN - NLM
STAT- MEDLINE
DCOM- 20100329
LR  - 20220317
IS  - 1460-2105 (Electronic)
IS  - 0027-8874 (Linking)
VI  - 102
IP  - 6
DP  - 2010 Mar 17
TI  - State payer mandates to cover care in US oncology trials: do science and ethics
      matter?
PG  - 376-90
LID - 10.1093/jnci/djq028 [doi]
AB  - BACKGROUND: In the United States, Medicare-eligible participants' costs for
      routine care and complications from cancer clinical trials are covered by
      Medicare, but other people depend on state insurance mandates to assure coverage.
      METHODS: State mandates were reviewed for requirements to assure trials'
      scientific and ethical soundness, whom they covered and omitted, scope, and
      coverage for participants' research-related injuries in addition to routine care 
      costs. RESULTS: Twenty-six states mandated coverage. Four states (15%) required
      scientific peer review for all studies. For 20 states (80%), an approved
      investigational new drug qualified as scientific review. In 10 states (38%),
      institutional review board (IRB) approval could replace scientific review.
      Twenty-four states (92%) permitted trials without academic medical connection.
      All states covered privately insured patients; seven (27%) included government
      and Medicaid patients. Fourteen states (54%) covered phase I to phase IV trials. 
      Sixteen states (62%) covered treatment trials only; one (4%) covered prevention, 
      detection, treatment, and palliation. Thirteen states (50%) covered
      research-related injuries. Only seven states (27%) required IRB approval. Three
      states (12%) required commensurate risks and benefits; 23 (88%) had no standard. 
      Eight states (31%) required clinical equipoise with standard care; eight (31%)
      had no standard; and remaining states (46%) had unique standards. Two states (8%)
      addressed publication or registries. CONCLUSIONS: Most states did not demand
      independent scientific review, IRB review, or basic ethical features of
      high-quality trials; provided partial coverage; omitted prevention, detection,
      and palliation research; and omitted mandated coverage for research-related
      injuries. Few required evaluation, independence in publication, or posting trial 
      results. Further research on the impact of diverse state choices would improve
      policy making.
FAU - Taylor, Patrick L
AU  - Taylor PL
AD  - Children's Hospital Boston, Harvard Medical School, 300 Longwood Ave, Hun 106.3, 
      Boston, MA 02115, USA. patrick.taylor@childrens.harvard.edu
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20100302
PL  - United States
TA  - J Natl Cancer Inst
JT  - Journal of the National Cancer Institute
JID - 7503089
RN  - 0 (Drugs, Investigational)
SB  - IM
MH  - Clinical Trials as Topic/*economics/*ethics/legislation & jurisprudence
MH  - Drugs, Investigational/therapeutic use
MH  - *Ethics Committees, Research
MH  - Ethics, Research
MH  - *Government Regulation
MH  - Humans
MH  - *Insurance Coverage/economics/ethics/legislation & jurisprudence
MH  - Medical Oncology/economics/ethics/legislation & jurisprudence
MH  - Medicare
MH  - *Neoplasms/diagnosis/therapy
MH  - Research Subjects
MH  - United States
MH  - United States Food and Drug Administration
EDAT- 2010/03/04 06:00
MHDA- 2010/03/30 06:00
CRDT- 2010/03/04 06:00
PHST- 2010/03/04 06:00 [entrez]
PHST- 2010/03/04 06:00 [pubmed]
PHST- 2010/03/30 06:00 [medline]
AID - djq028 [pii]
AID - 10.1093/jnci/djq028 [doi]
PST - ppublish
SO  - J Natl Cancer Inst. 2010 Mar 17;102(6):376-90. doi: 10.1093/jnci/djq028. Epub
      2010 Mar 2.


PMID- 20197306
OWN - NLM
STAT- MEDLINE
DCOM- 20100616
LR  - 20100312
IS  - 1744-5019 (Electronic)
IS  - 0360-5310 (Linking)
VI  - 35
IP  - 2
DP  - 2010 Apr
TI  - Organ donation by capital prisoners in China: reflections in Confucian ethics.
PG  - 197-212
LID - 10.1093/jmp/jhq008 [doi]
AB  - This article discusses the practice and development of organ donation by capital 
      prisoners in China. It analyzes the issue of informed consent regarding organ
      donation from capital prisoners in light of Confucian ethics and expounds the
      point that under the influence of Confucianism, China is a country that attaches 
      great importance to the role of the family in practicing informed consent in
      various areas, the area of organ donation from capital prisoners included. It
      argues that a proper form of organ donation from capital prisoners can be
      justified within the Confucian moral context in which the proper interests of
      capital prisoners and their families, the benefit of organ receptors, and a
      rightful order of society should all be appropriately considered. From the
      Confucian perspective, the act of donating organs from a capital prisoner must be
      decided by both the prisoner and his/her family (i.e., each side should hold a
      veto power), whereas such donation, in the proper circumstance protected by a
      rightful procedure, should be appreciated as a morally praiseworthy act of the
      prisoner who is willing to make the final effort to repent and correct his/her
      evil conduct and to leave something good to the world.
FAU - Wang, Mingxu
AU  - Wang M
AD  - Xi'an Jiaotong University Medical College, Mailbox 138, 76 Yantaxi Road, Xi'an
      710061, People's Republic of China. wangmx601@mail.xjtu.edu.cn
FAU - Wang, Xueliang
AU  - Wang X
LA  - eng
PT  - Journal Article
DEP - 20100302
PL  - United States
TA  - J Med Philos
JT  - The Journal of medicine and philosophy
JID - 7610512
SB  - IM
CIN - J Med Philos. 2010 Apr;35(2):220-2. PMID: 20176708
CIN - J Med Philos. 2010 Apr;35(2):213-9. PMID: 20176710
MH  - *Capital Punishment
MH  - China
MH  - *Confucianism
MH  - Family
MH  - Humans
MH  - Informed Consent/*ethics/legislation & jurisprudence
MH  - Male
MH  - Morals
MH  - *Prisoners
MH  - Public Policy
MH  - *Religion and Medicine
MH  - Tissue and Organ Procurement/*ethics/legislation & jurisprudence
EDAT- 2010/03/04 06:00
MHDA- 2010/06/17 06:00
CRDT- 2010/03/04 06:00
PHST- 2010/03/04 06:00 [entrez]
PHST- 2010/03/04 06:00 [pubmed]
PHST- 2010/06/17 06:00 [medline]
AID - jhq008 [pii]
AID - 10.1093/jmp/jhq008 [doi]
PST - ppublish
SO  - J Med Philos. 2010 Apr;35(2):197-212. doi: 10.1093/jmp/jhq008. Epub 2010 Mar 2.


PMID- 20197184
OWN - NLM
STAT- MEDLINE
DCOM- 20100322
LR  - 20100303
IS  - 1097-6752 (Electronic)
IS  - 0889-5406 (Linking)
VI  - 137
IP  - 3
DP  - 2010 Mar
TI  - Litigation, Legislation, and Ethics. Are patients covered under a state's
      consumer protection act from doctors' acts?
PG  - 433-5
LID - 10.1016/j.ajodo.2010.01.001 [doi]
FAU - Jerrold, Laurance
AU  - Jerrold L
AD  - School of Orthodontics, Jacksonville University, Jacksonville, FL, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Orthod Dentofacial Orthop
JT  - American journal of orthodontics and dentofacial orthopedics : official
      publication of the American Association of Orthodontists, its constituent
      societies, and the American Board of Orthodontics
JID - 8610224
SB  - IM
MH  - Consumer Advocacy/*legislation & jurisprudence
MH  - Humans
MH  - *Informed Consent
MH  - Kansas
MH  - Malpractice/*legislation & jurisprudence
MH  - State Government
EDAT- 2010/03/04 06:00
MHDA- 2010/03/23 06:00
CRDT- 2010/03/04 06:00
PHST- 2009/12/01 00:00 [received]
PHST- 2010/01/01 00:00 [revised]
PHST- 2010/01/01 00:00 [accepted]
PHST- 2010/03/04 06:00 [entrez]
PHST- 2010/03/04 06:00 [pubmed]
PHST- 2010/03/23 06:00 [medline]
AID - S0889-5406(10)00002-8 [pii]
AID - 10.1016/j.ajodo.2010.01.001 [doi]
PST - ppublish
SO  - Am J Orthod Dentofacial Orthop. 2010 Mar;137(3):433-5. doi:
      10.1016/j.ajodo.2010.01.001.


PMID- 20195616
OWN - NLM
STAT- MEDLINE
DCOM- 20101112
LR  - 20181113
IS  - 1433-0350 (Electronic)
IS  - 0256-7040 (Linking)
VI  - 26
IP  - 8
DP  - 2010 Aug
TI  - Pediatric epilepsy surgery and sudden unexpected death epilepsy: the contribution
      of a Brazilian epilepsy surgery program.
PG  - 1075-9
LID - 10.1007/s00381-010-1108-z [doi]
AB  - BACKGROUND AND PURPOSE: Individuals with epilepsy are at higher risk of death
      than those from the general population, and sudden unexpected death in epilepsy
      (SUDEP) is the most important direct epilepsy-related cause of death. Epilepsies 
      in the pediatric group are more frequently associated with known potentially risk
      factors for SUDEP, and a treatment resulting in an improved seizure control may
      also decrease mortality. The aim of this study is to identify the incidence of
      SUDEP in a group of operated-on children and adolescents. METHODS: We analyzed
      267 patients up to 18 years old, with medically intractable epilepsy submitted to
      surgery. We considered the age at surgery, the seizure type, the pathological
      findings, and the seizure outcome. Data were prospectively collected, according
      to the protocols of our institution's ethics committee. RESULTS: The percentage
      of boys was 58.05. A good outcome was achieved in 72.6% of the cases and a bad
      outcome in 27.4%. Nine patients died during follow-up, six from clinical
      complications, and one from SUDEP. All patients who died during the long-term
      follow-up had persisted with refractory postoperative seizures. The patient who
      died from SUDEP died during a generalized tonic-clonic seizure. CONCLUSIONS: Of
      the patients, 72.6% had excellent postoperative outcome, and one patient died of 
      SUDEP. All patients who died had had disabling seizures' persistence. The
      surgical treatment of epilepsy in children and adolescents is an efficient
      therapy for the medically intractable symptomatic epilepsies and also for the
      reduction of mortality and SUDEP risks.
FAU - Terra, Vera C
AU  - Terra VC
AD  - Departamento de Neurociencias e Ciencias do Comportamento, Faculdade de Medicina 
      de Ribeirao Preto, Universidade de Sao Paulo, Centro de Cirurgia de Epilepsia,
      Ribeirao Preto, Sao Paulo, Brazil. v.c.terra@rnp.fmrp.usp.br
FAU - Scorza, Fulvio A
AU  - Scorza FA
FAU - Cavalheiro, Esper A
AU  - Cavalheiro EA
FAU - Wichert-Ana, Lauro
AU  - Wichert-Ana L
FAU - Pinto, Kylvia G F D
AU  - Pinto KG
FAU - Machado, Helio R
AU  - Machado HR
FAU - Sakamoto, Americo C
AU  - Sakamoto AC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100302
PL  - Germany
TA  - Childs Nerv Syst
JT  - Child's nervous system : ChNS : official journal of the International Society for
      Pediatric Neurosurgery
JID - 8503227
SB  - IM
MH  - Adolescent
MH  - Brazil/epidemiology
MH  - Child
MH  - Child, Preschool
MH  - Death, Sudden/*epidemiology/*etiology
MH  - Epilepsy/*complications/*surgery
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Neurosurgical Procedures
MH  - Treatment Outcome
EDAT- 2010/03/03 06:00
MHDA- 2010/11/13 06:00
CRDT- 2010/03/03 06:00
PHST- 2009/08/24 00:00 [received]
PHST- 2010/02/03 00:00 [accepted]
PHST- 2010/03/03 06:00 [entrez]
PHST- 2010/03/03 06:00 [pubmed]
PHST- 2010/11/13 06:00 [medline]
AID - 10.1007/s00381-010-1108-z [doi]
PST - ppublish
SO  - Childs Nerv Syst. 2010 Aug;26(8):1075-9. doi: 10.1007/s00381-010-1108-z. Epub
      2010 Mar 2.


PMID- 20195588
OWN - NLM
STAT- MEDLINE
DCOM- 20100726
LR  - 20220129
IS  - 1432-1041 (Electronic)
IS  - 0031-6970 (Linking)
VI  - 66
IP  - 6
DP  - 2010 Jun
TI  - A pilot study to evaluate a community pharmacy-based monitoring system to
      identify adverse drug reactions associated with paediatric medicines use.
PG  - 627-32
LID - 10.1007/s00228-010-0790-9 [doi]
AB  - INTRODUCTION: Current pharmacovigilance systems are limited by spontaneous
      reporting of adverse drug reactions (ADRs), lack of a denominator, and lower than
      expected reporting rates. The aim of our study was to undertake a formal pilot
      evaluation of a community pharmacy-led ADR monitoring system. METHODS: The
      setting was community pharmacies in five Health Boards areas of Scotland.
      Subjects were parents, guardians, or children presenting prescriptions for
      children 16 years and under prescribed serotonin specific reuptake inhibitors
      (SSRI), anticonvulsants, or medicines for the treatment of attention deficit
      hyperactivity disorder (ADHD). All pharmacies (n = 827) were invited to
      participate. Over a 3-month period they were asked to identify prescriptions for 
      targeted medicines and give out an ADR questionnaire. Questionnaire content
      included child demography, duration of medicine use, indication, perceived ADRs, 
      and their description and severity. The study was approved by the North of
      Scotland Research Ethics Committee. RESULTS: Seventy-two community pharmacists
      (8.7%) agreed to take part. Two hundred and twenty-nine questionnaires were
      distributed and 55 (24%) completed and returned by parents. Forty-one
      questionnaires related to ADHD medications, 13 to anticonvulsants, and 1 to an
      SSRI. Thirty questionnaires reported 44 possible ADRs, 19 of which were related
      to methylphenidate. CONCLUSIONS: The proposed ADR monitoring system identified
      expected ADRs thus demonstrating face and content validity for our approach.
      However the process was limited by low community pharmacist participation rates
      and low questionnaire return rates.
FAU - Tobaiqy, Mansour
AU  - Tobaiqy M
AD  - Division of Applied Health Sciences, The Aberdeen Medical School, The University 
      of Aberdeen, Abeerden, UK. m.tobaiqy@abdn.ac.uk
FAU - Stewart, Derek
AU  - Stewart D
FAU - Helms, Peter J
AU  - Helms PJ
FAU - Bond, Christine
AU  - Bond C
FAU - Lee, Amanda Jane
AU  - Lee AJ
FAU - Bateman, Nick
AU  - Bateman N
FAU - McCaig, Dorothy
AU  - McCaig D
FAU - McLay, James
AU  - McLay J
LA  - eng
GR  - CZG/2/267/CSO_/Chief Scientist Office/United Kingdom
PT  - Journal Article
DEP - 20100302
PL  - Germany
TA  - Eur J Clin Pharmacol
JT  - European journal of clinical pharmacology
JID - 1256165
RN  - 0 (Anticonvulsants)
RN  - 0 (Propylamines)
RN  - 0 (Serotonin Uptake Inhibitors)
RN  - 207ZZ9QZ49 (Methylphenidate)
RN  - 57WVB6I2W0 (Atomoxetine Hydrochloride)
RN  - JL5DK93RCL (Melatonin)
SB  - IM
MH  - Adolescent
MH  - Adverse Drug Reaction Reporting Systems/*organization & administration
MH  - Anticonvulsants/*adverse effects
MH  - Atomoxetine Hydrochloride
MH  - Child
MH  - Child, Preschool
MH  - Drug-Related Side Effects and Adverse Reactions/chemically induced/*epidemiology
MH  - Humans
MH  - Incidence
MH  - Infant
MH  - Infant, Newborn
MH  - Melatonin/adverse effects
MH  - Methylphenidate/*adverse effects
MH  - Pharmacies/*statistics & numerical data
MH  - Pilot Projects
MH  - Propylamines/adverse effects
MH  - Prospective Studies
MH  - Sample Size
MH  - Scotland
MH  - Serotonin Uptake Inhibitors/*adverse effects
MH  - Severity of Illness Index
MH  - Surveys and Questionnaires
EDAT- 2010/03/03 06:00
MHDA- 2010/07/27 06:00
CRDT- 2010/03/03 06:00
PHST- 2009/07/17 00:00 [received]
PHST- 2010/01/15 00:00 [accepted]
PHST- 2010/03/03 06:00 [entrez]
PHST- 2010/03/03 06:00 [pubmed]
PHST- 2010/07/27 06:00 [medline]
AID - 10.1007/s00228-010-0790-9 [doi]
PST - ppublish
SO  - Eur J Clin Pharmacol. 2010 Jun;66(6):627-32. doi: 10.1007/s00228-010-0790-9. Epub
      2010 Mar 2.


PMID- 20195441
OWN - NLM
STAT- MEDLINE
DCOM- 20100525
LR  - 20220331
IS  - 1660-4601 (Electronic)
IS  - 1660-4601 (Linking)
VI  - 7
IP  - 1
DP  - 2010 Jan
TI  - Theoretical models and operational frameworks in public health ethics.
PG  - 189-202
LID - 10.3390/ijerph7010189 [doi]
AB  - The article is divided into three sections: (i) an overview of the main ethical
      models in public health (theoretical foundations); (ii) a summary of several
      published frameworks for public health ethics (practical frameworks); and (iii) a
      few general remarks. Rather than maintaining the superiority of one position over
      the others, the main aim of the article is to summarize the basic approaches
      proposed thus far concerning the development of public health ethics by
      describing and comparing the various ideas in the literature. With this in mind, 
      an extensive list of references is provided.
FAU - Petrini, Carlo
AU  - Petrini C
AD  - Italian National Institute of Health, Office of the President, Bioethics Unit,
      I-00162 Rome, Italy. carlo.petrini@iss.it
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100118
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
SB  - IM
MH  - Culture
MH  - Ethics, Clinical
MH  - *Models, Theoretical
MH  - Philosophy
MH  - Public Health/*ethics
RF  - 78
PMC - PMC2819784
OTO - NOTNLM
OT  - *ethics
OT  - *foundations
OT  - *frameworks
OT  - *models
OT  - *personalism
OT  - *public health
OT  - *utilitarianism
EDAT- 2010/03/03 06:00
MHDA- 2010/05/26 06:00
CRDT- 2010/03/03 06:00
PHST- 2009/12/24 00:00 [received]
PHST- 2010/01/13 00:00 [accepted]
PHST- 2010/03/03 06:00 [entrez]
PHST- 2010/03/03 06:00 [pubmed]
PHST- 2010/05/26 06:00 [medline]
AID - 10.3390/ijerph7010189 [doi]
AID - ijerph7010189 [pii]
PST - ppublish
SO  - Int J Environ Res Public Health. 2010 Jan;7(1):189-202. doi:
      10.3390/ijerph7010189. Epub 2010 Jan 18.


PMID- 20195426
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1715-6181 (Electronic)
IS  - 0008-3194 (Linking)
VI  - 54
IP  - 1
DP  - 2010 Mar
TI  - Jurisprudence and business management course content taught at accredited
      chiropractic colleges: A comparative audit.
PG  - 52-9
AB  - INTRODUCTION: the purpose of this study was to conduct a comparative audit of the
      jurisprudence and business management courses offered at a number of different
      accredited chiropractic colleges. METHODS: Faculty members responsible for
      teaching students jurisprudence and/or business management courses at a number of
      accredited colleges were contacted and asked to electronically submit their
      course outlines for review. RESULTS: Of the 62 different topics delivered at the 
      11 chiropractic colleges surveyed, not one topic was taught at all of them. The
      following topics were taught at 10 of the 11 respondent chiropractic colleges:
      business plan development; ethics and codes of conduct and; office
      staff/employees. Several topics were only taught at one accredited chiropractic
      college. CONCLUSION: While most chiropractic colleges provide some education in
      the areas of jurisprudence and business management, it would appear that there is
      no consensus opinion or 'model curriculum' on these topics towards which
      chiropractic programs may align themselves. Based on a literature search, this
      study is the first of its kind. A more extensive study is required, as well as a 
      Delphi process to determine what should be taught to chiropractic students with
      respect to jurisprudence and business management in order to protect the public
      interest.
FAU - Gleberzon, Brian J
AU  - Gleberzon BJ
AD  - Professor and Chair, Department of Applied Chiropractic, Canadian Memorial
      Chiropractic College, 6100 Leslie St, Toronto, ON M2H 3J1. Tel: 416-482-4476.
      Email: bgleberzon@cmcc.ca.
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - J Can Chiropr Assoc
JT  - The Journal of the Canadian Chiropractic Association
JID - 7507184
PMC - PMC2829686
OTO - NOTNLM
OT  - chiropractic
OT  - college
OT  - curriculum
OT  - jurisprudence
OT  - management
EDAT- 2010/03/03 06:00
MHDA- 2010/03/03 06:01
CRDT- 2010/03/03 06:00
PHST- 2010/03/03 06:00 [entrez]
PHST- 2010/03/03 06:00 [pubmed]
PHST- 2010/03/03 06:01 [medline]
PST - ppublish
SO  - J Can Chiropr Assoc. 2010 Mar;54(1):52-9.


PMID- 20195185
OWN - NLM
STAT- MEDLINE
DCOM- 20100813
LR  - 20100426
IS  - 1473-5628 (Electronic)
IS  - 0143-3636 (Linking)
VI  - 31
IP  - 6
DP  - 2010 Jun
TI  - Do we need a universal 'code of ethics' in nuclear medicine?
PG  - 477-81
LID - 10.1097/MNM.0b013e328337f94b [doi]
AB  - Recent years have seen huge advances in medicine and the science of medicine.
      Nuclear medicine has been no exception and there has been rapid acceptance of new
      concepts, new technologies and newer ways of working. Ethical principles have
      been traditionally considered as generic skills applicable to wide groups of
      scientists and doctors, with only token refinement at specialty level. Specialist
      bodies across the world representing wide groups of practitioners frequently have
      subgroups dealing exclusively with ethical issues. It could easily be argued that
      the basic principles of ethical practice adopted by specialist bodies closest to 
      nuclear medicine practice, such as radiology and oncology, will also be
      applicable to nuclear medicine and that time and effort need not be spent on
      specifying a separate code for nuclear medicine. It could also be argued that
      nuclear medicine is an independent specialty and some (if not most) practitioners
      will not be aware of the guidelines adopted by other specialist societies, and
      that there is a need for re-iteration of ethical principles at the specialty
      level and on a worldwide scale.In this article we would like to present a brief
      history of medical ethics, discuss some of the advances in nuclear medicine and
      their associated ethical aspects, as well as list a framework of principles for
      consideration, should a specialist body deem it suitable to establish a 'code of 
      ethics' for nuclear medicine.
FAU - Ramesh, Chandakacharla N
AU  - Ramesh CN
AD  - Department of Nuclear Medicine, Royal Liverpool University Hospital, Liverpool,
      UK.
FAU - Vinjamuri, Sobhan
AU  - Vinjamuri S
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Nucl Med Commun
JT  - Nuclear medicine communications
JID - 8201017
SB  - IM
MH  - *Codes of Ethics
MH  - Ethics, Research
MH  - Nuclear Medicine/*ethics
MH  - Radiology/ethics
MH  - Societies, Scientific/ethics
MH  - United States
RF  - 18
EDAT- 2010/03/03 06:00
MHDA- 2010/08/14 06:00
CRDT- 2010/03/03 06:00
PHST- 2010/03/03 06:00 [entrez]
PHST- 2010/03/03 06:00 [pubmed]
PHST- 2010/08/14 06:00 [medline]
AID - 10.1097/MNM.0b013e328337f94b [doi]
PST - ppublish
SO  - Nucl Med Commun. 2010 Jun;31(6):477-81. doi: 10.1097/MNM.0b013e328337f94b.


PMID- 20195082
OWN - NLM
STAT- MEDLINE
DCOM- 20100602
LR  - 20110110
IS  - 1539-073X (Electronic)
IS  - 1520-9229 (Linking)
VI  - 12
IP  - 1
DP  - 2010 Jan-Mar
TI  - Americans with Disabilities Act-related considerations when an alcoholic nurse is
      your employee: when is a nurse legally considered a "direct threat" to patient
      safety?
PG  - 21-4; quiz 25-6
LID - 10.1097/NHL.0b013e3181d20125 [doi]
AB  - When contemplating the legal and ethical issues surrounding employment of an
      alcoholic nurse, nursing administrators are challenged with recognizing and
      upholding the Americans With Disabilities Act (ADA)-related civil rights of their
      employees while ensuring the quality of care provided by the practitioners in
      their facility. The "direct-threat" exception to disability accommodations
      relieves employers from making accommodations for a disability if those
      accommodations would necessitate lowering patient care quality standards.
      According to the ADA's direct-threat exception, a healthcare facility may legally
      terminate a nurse with the disability of alcoholism if that practitioner poses a 
      threat to the safety of its patients. This article provides an informative
      overview of alcoholism as a disability in the context of nursing. A nurse
      administrator could use the information provided to objectively and competently
      make a determination of direct threat. The focus is on the importance of making
      an objective and unbiased assessment when determining if an alcoholic nurse meets
      the direct-threat" criteria that eliminates the requirement for making reasonable
      accommodations for a disabled employee. General ADA guidelines are provided, but 
      the assessment must be individualized based on the patient care setting, the
      requirements of the position, and the nurse's present ability to safely perform
      the essential job functions.
FAU - Menendez, Juliet Battard
AU  - Menendez JB
AD  - Hospital Quality and Patient Safety, Miami Beach, FL 33155, USA. jb810@nova.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - JONAS Healthc Law Ethics Regul
JT  - JONA'S healthcare law, ethics and regulation
JID - 100888423
MH  - *Alcoholism
MH  - Decision Making
MH  - Disabled Persons/*legislation & jurisprudence
MH  - Guidelines as Topic
MH  - Humans
MH  - Nursing Staff/*legislation & jurisprudence
MH  - Professional Impairment/*legislation & jurisprudence
MH  - *Risk Management
MH  - United States
EDAT- 2010/03/03 06:00
MHDA- 2010/06/03 06:00
CRDT- 2010/03/03 06:00
PHST- 2010/03/03 06:00 [entrez]
PHST- 2010/03/03 06:00 [pubmed]
PHST- 2010/06/03 06:00 [medline]
AID - 10.1097/NHL.0b013e3181d20125 [doi]
AID - 00128488-201001000-00005 [pii]
PST - ppublish
SO  - JONAS Healthc Law Ethics Regul. 2010 Jan-Mar;12(1):21-4; quiz 25-6. doi:
      10.1097/NHL.0b013e3181d20125.


PMID- 20195081
OWN - NLM
STAT- MEDLINE
DCOM- 20100602
LR  - 20100302
IS  - 1539-073X (Electronic)
IS  - 1520-9229 (Linking)
VI  - 12
IP  - 1
DP  - 2010 Jan-Mar
TI  - Online ethics discussion forum facilitates medical center clinical ethics case
      reviews.
PG  - 15-20
LID - 10.1097/NHL.0b013e3181d2a5a2 [doi]
AB  - Clinical ethics consultants are increasingly called upon to give counsel in the
      clinical arena on issues including but not limited to withdrawal or withholding
      of specific medical treatments, assisting minors and mentally impaired patients
      with care decisions, working with difficult patients and families, identifying
      appropriate surrogate decision makers, and executing advance directives and
      end-of-life decisions. Often, the consultant may need to convene the ethics
      committee members to review and provide feedback for a given case. This process
      may be difficult to schedule in a timely way because of member's clinical and
      other work-related obligations. To this end, the University of Illinois Medical
      Center in Chicago has set up a unique Web board to facilitate ongoing case
      discussions via a secured, password-protected ethics committee online forum. This
      allows for real-time review by all ethics committee members. We will explain our 
      online process as well as discuss our clinical case experiences.
FAU - Ramsey, David J
AU  - Ramsey DJ
AD  - Department of Ophthalmology, The Wilmer Eye Institute, John Hopkins Hospital,
      Baltimore, Maryland, USA.
FAU - Schmidt, Mary Lou
AU  - Schmidt ML
FAU - Anderson-Shaw, Lisa
AU  - Anderson-Shaw L
LA  - eng
PT  - Journal Article
PL  - United States
TA  - JONAS Healthc Law Ethics Regul
JT  - JONA'S healthcare law, ethics and regulation
JID - 100888423
MH  - *Ethics Committees, Clinical
MH  - *Ethics Consultation
MH  - Humans
MH  - Interdisciplinary Communication
MH  - *Internet
MH  - United States
EDAT- 2010/03/03 06:00
MHDA- 2010/06/03 06:00
CRDT- 2010/03/03 06:00
PHST- 2010/03/03 06:00 [entrez]
PHST- 2010/03/03 06:00 [pubmed]
PHST- 2010/06/03 06:00 [medline]
AID - 10.1097/NHL.0b013e3181d2a5a2 [doi]
AID - 00128488-201001000-00004 [pii]
PST - ppublish
SO  - JONAS Healthc Law Ethics Regul. 2010 Jan-Mar;12(1):15-20. doi:
      10.1097/NHL.0b013e3181d2a5a2.


PMID- 20195078
OWN - NLM
STAT- MEDLINE
DCOM- 20100602
LR  - 20100302
IS  - 1539-073X (Electronic)
IS  - 1520-9229 (Linking)
VI  - 12
IP  - 1
DP  - 2010 Jan-Mar
TI  - JONA's Healthcare Law, Ethics, & Regulation. Letter from the editor.
PG  - 1
LID - 10.1097/NHL.0b013e3181d2b584 [doi]
FAU - Cady, Rebecca F
AU  - Cady RF
LA  - eng
PT  - Editorial
PT  - Introductory Journal Article
PL  - United States
TA  - JONAS Healthc Law Ethics Regul
JT  - JONA'S healthcare law, ethics and regulation
JID - 100888423
MH  - *Ethics, Clinical
MH  - Health Personnel/*legislation & jurisprudence
MH  - Humans
MH  - United States
EDAT- 2010/03/03 06:00
MHDA- 2010/06/03 06:00
CRDT- 2010/03/03 06:00
PHST- 2010/03/03 06:00 [entrez]
PHST- 2010/03/03 06:00 [pubmed]
PHST- 2010/06/03 06:00 [medline]
AID - 10.1097/NHL.0b013e3181d2b584 [doi]
AID - 00128488-201001000-00001 [pii]
PST - ppublish
SO  - JONAS Healthc Law Ethics Regul. 2010 Jan-Mar;12(1):1. doi:
      10.1097/NHL.0b013e3181d2b584.


PMID- 20194809
OWN - NLM
STAT- MEDLINE
DCOM- 20100802
LR  - 20220409
IS  - 1535-4970 (Electronic)
IS  - 1073-449X (Linking)
VI  - 182
IP  - 1
DP  - 2010 Jul 1
TI  - End-of-life decision making in the intensive care unit.
PG  - 6-11
LID - 10.1164/rccm.201001-0071CI [doi]
AB  - Increasingly in the United States and other countries, medical decisions,
      including those at the end of life, are made using a shared decision-making
      model. Under this model, physicians and other clinicians help patients clarify
      their values and reach consensus about treatment courses consistent with them.
      Because most critically ill patients are decisionally impaired, family members
      and other surrogates must make end-of-life decisions for them, ideally in accord 
      with a substituted judgment standard. Physicians generally make decisions for
      patients who lack families or other surrogates and have no advance directives,
      based on a best interests standard and occasionally in consultation with other
      physicians or with review by a hospital ethics committee. End-of-life decisions
      for patients with surrogates usually are made at family conferences, the
      functioning of which can be improved by several methods that have been
      demonstrated to improve communications. Facilitative ethics consultations can be 
      helpful in resolving conflicts when physicians and families disagree in
      end-of-life decisions. Ethics committees actually are allowed to make such
      decisions in one state when disagreements cannot be resolved otherwise.
FAU - Luce, John M
AU  - Luce JM
AD  - Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital,
      1001 Potrero Avenue, Room 5K1, San Francisco, CA 94110, USA.
      jluce@medsfgh.ucsf.edu
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100301
PL  - United States
TA  - Am J Respir Crit Care Med
JT  - American journal of respiratory and critical care medicine
JID - 9421642
SB  - IM
MH  - Advance Directives
MH  - Ethics Committees, Clinical/legislation & jurisprudence
MH  - Humans
MH  - *Intensive Care Units
MH  - Palliative Care
MH  - Physician-Patient Relations
MH  - *Terminal Care
MH  - *Third-Party Consent
MH  - Withholding Treatment
RF  - 70
EDAT- 2010/03/03 06:00
MHDA- 2010/08/03 06:00
CRDT- 2010/03/03 06:00
PHST- 2010/03/03 06:00 [entrez]
PHST- 2010/03/03 06:00 [pubmed]
PHST- 2010/08/03 06:00 [medline]
AID - 201001-0071CI [pii]
AID - 10.1164/rccm.201001-0071CI [doi]
PST - ppublish
SO  - Am J Respir Crit Care Med. 2010 Jul 1;182(1):6-11. doi:
      10.1164/rccm.201001-0071CI. Epub 2010 Mar 1.


PMID- 20194805
OWN - NLM
STAT- MEDLINE
DCOM- 20100524
LR  - 20211020
IS  - 1931-7913 (Electronic)
IS  - 1931-7913 (Linking)
VI  - 9
IP  - 1
DP  - 2010 Spring
TI  - Educational challenges of molecular life science: Characteristics and
      implications for education and research.
PG  - 25-33
LID - 10.1187/cbe.08-09-0055 [doi]
AB  - Molecular life science is one of the fastest-growing fields of scientific and
      technical innovation, and biotechnology has profound effects on many aspects of
      daily life-often with deep, ethical dimensions. At the same time, the content is 
      inherently complex, highly abstract, and deeply rooted in diverse disciplines
      ranging from "pure sciences," such as math, chemistry, and physics, through
      "applied sciences," such as medicine and agriculture, to subjects that are
      traditionally within the remit of humanities, notably philosophy and ethics.
      Together, these features pose diverse, important, and exciting challenges for
      tomorrow's teachers and educational establishments. With backgrounds in molecular
      life science research and secondary life science teaching, we (Tibell and
      Rundgren, respectively) bring different experiences, perspectives, concerns, and 
      awareness of these issues. Taking the nature of the discipline as a starting
      point, we highlight important facets of molecular life science that are both
      characteristic of the domain and challenging for learning and education. Of these
      challenges, we focus most detail on content, reasoning difficulties, and
      communication issues. We also discuss implications for education research and
      teaching in the molecular life sciences.
FAU - Tibell, Lena A E
AU  - Tibell LA
AD  - Department of Science and Technology, Linkoping University, Norrkoping, Sweden.
      lenti@itn.liu.se
FAU - Rundgren, Carl-Johan
AU  - Rundgren CJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - CBE Life Sci Educ
JT  - CBE life sciences education
JID - 101269039
SB  - IM
MH  - Biological Science Disciplines/*education
MH  - Molecular Biology/*education
MH  - Research
MH  - Teaching/*methods
PMC - PMC2830159
EDAT- 2010/03/03 06:00
MHDA- 2010/05/25 06:00
CRDT- 2010/03/03 06:00
PHST- 2010/03/03 06:00 [entrez]
PHST- 2010/03/03 06:00 [pubmed]
PHST- 2010/05/25 06:00 [medline]
AID - 9/1/25 [pii]
AID - 10.1187/cbe.08-09-0055 [doi]
PST - ppublish
SO  - CBE Life Sci Educ. 2010 Spring;9(1):25-33. doi: 10.1187/cbe.08-09-0055.


PMID- 20194392
OWN - NLM
STAT- MEDLINE
DCOM- 20100610
LR  - 20190709
IS  - 1943-4723 (Electronic)
IS  - 0002-8177 (Linking)
VI  - 141
IP  - 3
DP  - 2010 Mar
TI  - What are the ethical issues to consider in the design of my web site?
PG  - 342-4
FAU - Wentworth, Rod B
AU  - Wentworth RB
AD  - American Dental Association Council on Ethics, Bylaws and Judicial Affairs,
      Chicago, IL 60611, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Am Dent Assoc
JT  - Journal of the American Dental Association (1939)
JID - 7503060
SB  - IM
MH  - Dental Care/ethics
MH  - Dentists/*ethics
MH  - *Ethics, Dental
MH  - Humans
MH  - Internet/*ethics
MH  - Marketing of Health Services/ethics
MH  - Truth Disclosure
EDAT- 2010/03/03 06:00
MHDA- 2010/06/11 06:00
CRDT- 2010/03/03 06:00
PHST- 2010/03/03 06:00 [entrez]
PHST- 2010/03/03 06:00 [pubmed]
PHST- 2010/06/11 06:00 [medline]
AID - S0002-8177(14)62303-5 [pii]
AID - 10.14219/jada.archive.2010.0170 [doi]
PST - ppublish
SO  - J Am Dent Assoc. 2010 Mar;141(3):342-4. doi: 10.14219/jada.archive.2010.0170.


PMID- 20194289
OWN - NLM
STAT- MEDLINE
DCOM- 20100427
LR  - 20220317
IS  - 1098-4275 (Electronic)
IS  - 0031-4005 (Linking)
VI  - 125
IP  - 4
DP  - 2010 Apr
TI  - Ethics consultation in children's hospitals: results from a survey of pediatric
      clinical ethicists.
PG  - 742-6
LID - 10.1542/peds.2009-1813 [doi]
AB  - OBJECTIVES: Ethics consultation is a widely endorsed mechanism for resolving
      conflict, facilitating communication, and easing moral distress in health care.
      Although ethics consultation has been well characterized in the adult setting,
      little is known about ethics consultation or ethics programs in pediatrics. We
      conducted a national survey of ethicists at freestanding children's hospitals to 
      explore the structures and processes of their ethics-consultation services and
      committees and to characterize their training and professional activities.
      METHODS: We contacted freestanding children's hospitals from the member list of
      the National Association of Children's Hospitals and Related Institutions (N =
      46) to identify the ethics leader at each institution. This individual was
      invited to complete an on-line survey instrument. The survey asked about
      ethicists' training to fulfill their ethics-related roles, their policies and
      methods for ethics consultation, and the structure and funding of their ethics
      committees. Thirty-three ethicists (72%) responded. RESULTS: On-the-job
      experience (73%) was the most frequently reported form of training; a minority of
      ethicists endorsed each other type of training. Although 60% of the respondents
      reported having a policy for ethics consultation, several elements recommended by
      national consensus statements were inconsistently included. In addition,
      respondents reported variable adherence to standard components of the
      consultation process, including meeting with the patient or family, following up 
      with the clinical team, and providing a written report of the consultation. A
      minority of respondents reported having salary support (33%), administrative
      support (46%), or a budget (24%) for their work in ethics. CONCLUSIONS: Although 
      ethics-consultation policies and practices at freestanding children's hospitals
      are generally well aligned with published norms, our data reveal imperfect
      adherence to consensus standards. Additional research is needed to determine how 
      this practice variation, as well as the lack of salary support, budgets, and
      administrative assistance, affect the quality of ethics consultation at these
      institutions.
FAU - Kesselheim, Jennifer C
AU  - Kesselheim JC
AD  - Department of Pediatric Oncology, Dana-Farber Cancer Institute, 44 Binney St,
      Boston, MA 02115, USA. jennifer_kesselheim@dfci.harvard.edu
FAU - Johnson, Judith
AU  - Johnson J
FAU - Joffe, Steven
AU  - Joffe S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20100301
PL  - United States
TA  - Pediatrics
JT  - Pediatrics
JID - 0376422
SB  - IM
MH  - Adult
MH  - Aged
MH  - Data Collection/*ethics/methods/trends
MH  - *Ethicists
MH  - Ethics Consultation/*ethics/trends
MH  - Female
MH  - Hospitals, Pediatric/*ethics/trends
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pediatrics/*ethics/methods/trends
EDAT- 2010/03/03 06:00
MHDA- 2010/04/28 06:00
CRDT- 2010/03/03 06:00
PHST- 2010/03/03 06:00 [entrez]
PHST- 2010/03/03 06:00 [pubmed]
PHST- 2010/04/28 06:00 [medline]
AID - peds.2009-1813 [pii]
AID - 10.1542/peds.2009-1813 [doi]
PST - ppublish
SO  - Pediatrics. 2010 Apr;125(4):742-6. doi: 10.1542/peds.2009-1813. Epub 2010 Mar 1.


PMID- 20194275
OWN - NLM
STAT- MEDLINE
DCOM- 20100427
LR  - 20100402
IS  - 1098-4275 (Electronic)
IS  - 0031-4005 (Linking)
VI  - 125
IP  - 4
DP  - 2010 Apr
TI  - An evidence-based overview of prenatal consultation with a focus on infants born 
      at the limits of viability.
PG  - e931-7
LID - 10.1542/peds.2009-1473 [doi]
AB  - Before the delivery of a premature infant, a prenatal consultation between
      parents and physicians provides the opportunity to establish a trusting
      relationship and create a supportive environment for decision-making concerning
      neonatal resuscitation. The ideal consult enables physicians to educate parents
      about preterm delivery and potential outcomes for their infant while providing
      parents with the time to ask questions and express their values. The uncertainty 
      that surrounds many decisions in the treatment and resuscitation of infants born 
      at the limits of viability creates a situation in which joint responsibility for 
      decision-making between parents and physicians is vital. In this review we
      examine ethical considerations regarding the resuscitation of infants born at the
      limits of viability and present the current policies established by the Neonatal 
      Resuscitation Program and the American Academy of Pediatrics. The parental and
      physician perspectives regarding the consultation experience are presented also. 
      Finally, a model for the prenatal consultation is introduced with suggestions for
      the incorporation of morbidity and mortality data as well as the structure and
      approach to discussion with parents with threatened preterm delivery.
FAU - Griswold, Katherine J
AU  - Griswold KJ
AD  - Department of Pediatrics, Case Western Reserve University School of Medicine,
      Cleveland, Ohio, USA.
FAU - Fanaroff, Jonathan M
AU  - Fanaroff JM
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100301
PL  - United States
TA  - Pediatrics
JT  - Pediatrics
JID - 0376422
SB  - IM
MH  - Evidence-Based Medicine/*ethics/methods
MH  - Fetal Viability/physiology
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Premature/growth & development
MH  - Infant, Premature, Diseases/diagnosis/therapy
MH  - Premature Birth/diagnosis/therapy
MH  - Prenatal Diagnosis/*ethics/methods
MH  - Professional-Family Relations/*ethics
MH  - Referral and Consultation/*ethics
RF  - 24
EDAT- 2010/03/03 06:00
MHDA- 2010/04/28 06:00
CRDT- 2010/03/03 06:00
PHST- 2010/03/03 06:00 [entrez]
PHST- 2010/03/03 06:00 [pubmed]
PHST- 2010/04/28 06:00 [medline]
AID - peds.2009-1473 [pii]
AID - 10.1542/peds.2009-1473 [doi]
PST - ppublish
SO  - Pediatrics. 2010 Apr;125(4):e931-7. doi: 10.1542/peds.2009-1473. Epub 2010 Mar 1.


PMID- 20194217
OWN - NLM
STAT- MEDLINE
DCOM- 20110406
LR  - 20220331
IS  - 1475-3901 (Electronic)
IS  - 1475-3898 (Linking)
VI  - 19
IP  - 6
DP  - 2010 Dec
TI  - Responding to patient safety incidents: the "seven pillars".
PG  - e11
LID - 10.1136/qshc.2008.031633 [doi]
AB  - BACKGROUND: Although acknowledged to be an ethical imperative for providers,
      disclosure following patient safety incidents remains the exception. The
      appropriate response to a patient safety incident and the disclosure of medical
      errors are neither easy nor obvious. An inadequate response to patient harm or an
      inappropriate disclosure may frustrate practitioners, dent their professional
      reputation, and alienate patients. METHODS: The authors have presented a
      descriptive study on the comprehensive process for responding to patient safety
      incidents, including the disclosure of medical errors adopted at a large, urban
      tertiary care centre in the United States. RESULTS: In the first two years
      post-implementation, the "seven pillars" process has led to more than 2,000
      incident reports annually, prompted more than 100 investigations with root cause 
      analysis, translated into close to 200 system improvements and served as the
      foundation of almost 106 disclosure conversations and 20 full disclosures of
      inappropriate or unreasonable care causing harm to patients. CONCLUSIONS:
      Adopting a policy of transparency represents a major shift in organisational
      focus and may take several years to implement. In our experience, the ability to 
      rapidly learn from, respond to, and modify practices based on investigation to
      improve the safety and quality of patient care is grounded in transparency.
FAU - McDonald, T B
AU  - McDonald TB
AD  - Department of MedicalEducation, College of Medicine, University of Illinois at
      Chicago, Illinois, USA. tmcd@uic.edu
FAU - Helmchen, L A
AU  - Helmchen LA
FAU - Smith, K M
AU  - Smith KM
FAU - Centomani, N
AU  - Centomani N
FAU - Gunderson, A
AU  - Gunderson A
FAU - Mayer, D
AU  - Mayer D
FAU - Chamberlin, W H
AU  - Chamberlin WH
LA  - eng
PT  - Journal Article
DEP - 20100301
PL  - England
TA  - Qual Saf Health Care
JT  - Quality & safety in health care
JID - 101136980
MH  - Academic Medical Centers
MH  - Chicago
MH  - Hospitals, Urban
MH  - Humans
MH  - Medical Errors/*prevention & control
MH  - *Safety Management
MH  - Truth Disclosure/*ethics
EDAT- 2010/03/03 06:00
MHDA- 2011/04/07 06:00
CRDT- 2010/03/03 06:00
PHST- 2010/03/03 06:00 [entrez]
PHST- 2010/03/03 06:00 [pubmed]
PHST- 2011/04/07 06:00 [medline]
AID - qshc.2008.031633 [pii]
AID - 10.1136/qshc.2008.031633 [doi]
PST - ppublish
SO  - Qual Saf Health Care. 2010 Dec;19(6):e11. doi: 10.1136/qshc.2008.031633. Epub
      2010 Mar 1.


PMID- 20193048
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1756-994X (Electronic)
IS  - 1756-994X (Linking)
VI  - 2
IP  - 1
DP  - 2010 Jan 21
TI  - The 1000 Genomes Project: new opportunities for research and social challenges.
PG  - 3
LID - 10.1186/gm124 [doi]
AB  - The 1000 Genomes Project, an international collaboration, is sequencing the whole
      genome of approximately 2,000 individuals from different worldwide populations.
      The central goal of this project is to describe most of the genetic variation
      that occurs at a population frequency greater than 1%. The results of this
      project will allow scientists to identify genetic variation at an unprecedented
      degree of resolution and will also help improve the imputation methods for
      determining unobserved genetic variants that are not represented on current
      genotyping arrays. By identifying novel or rare functional genetic variants,
      researchers will be able to pinpoint disease-causing genes in genomic regions
      initially identified by association studies. This level of detailed sequence
      information will also improve our knowledge of the evolutionary processes and the
      genomic patterns that have shaped the human species as we know it today. The new 
      data will also lay the foundation for future clinical applications, such as
      prediction of disease susceptibility and drug response. However, the forthcoming 
      availability of whole genome sequences at affordable prices will raise ethical
      concerns and pose potential threats to individual privacy. Nevertheless, we
      believe that these potential risks are outweighed by the benefits in terms of
      diagnosis and research, so long as rigorous safeguards are kept in place through 
      legislation that prevents discrimination on the basis of the results of genetic
      testing.
FAU - Via, Marc
AU  - Via M
AD  - ELSI/Samples Committee, 1000 Genomes Project, and Institute for Human Genetics,
      University of California at San Francisco, Box 2911, San Francisco, CA 94143,
      USA. marc.viagarcia@ucsf.edu.
FAU - Gignoux, Christopher
AU  - Gignoux C
FAU - Burchard, Esteban Gonzalez
AU  - Burchard EG
LA  - eng
PT  - Editorial
DEP - 20100121
PL  - England
TA  - Genome Med
JT  - Genome medicine
JID - 101475844
PMC - PMC2829928
EDAT- 2010/03/03 06:00
MHDA- 2010/03/03 06:01
CRDT- 2010/03/03 06:00
PHST- 2010/03/03 06:00 [entrez]
PHST- 2010/03/03 06:00 [pubmed]
PHST- 2010/03/03 06:01 [medline]
AID - gm124 [pii]
AID - 10.1186/gm124 [doi]
PST - epublish
SO  - Genome Med. 2010 Jan 21;2(1):3. doi: 10.1186/gm124.


PMID- 20192068
OWN - NLM
STAT- MEDLINE
DCOM- 20100316
LR  - 20100302
IS  - 0862-495X (Print)
IS  - 0862-495X (Linking)
VI  - 23
IP  - 1
DP  - 2010
TI  - [New views of modern medicine regarding treatment with stem cells, its practical 
      and ethical consequences].
PG  - 10-3
AB  - Embryonic stem (ES) cells recently became the Holy Grail for the treatment of
      multiple diseases including cancer. A recent discovery of Israeli scientists
      however shows that ES cells can also become one of the causes triggering cancer. 
      They base this hypothesis on a case of an Israeli boy suffering from Ataxia
      teleangiectasia, who developed cancer 4 years after ES transplantation. DNA
      analysis of the tumors showed that the malignant cells originated from the
      transplanted ES cells of the donors and not from the recipient's own cells. Given
      the fact that the therapeutic application of ES cells is still in the beginning, 
      it is therefore necessary to thoroughly verify and test all the risks of their
      potential therapeutic use. This article also discusses in detail ethical and
      other aspects of ES cells applications, in particular the differences in points
      of view between Christianity and Judaism. Israeli Health to address these issues 
      draws on traditional Judaism. Judaism defines an individual as a man if he cans a
      separate existence, in comparison with the human embryo, which is still directly 
      dependent on his or her mother. Therefore, in matters of saving lives, including 
      treatment options for improving the living, treatment with ES cells is tolerated 
      Judaism as a clear preference for live and self-sustaining individual, before a
      cluster of cells. On the other hand, it is clear that all these therapies must
      have their basic rules and ethical reasons. In Israel, research on ESC and
      allowed it to those obtained in the course of unsuccessful fertility treatment by
      artificial insemination.
FAU - Abramson, S
AU  - Abramson S
AD  - Department of Virology, Kimron Veterinary Institute, The Israeli State Veterinary
      Services and Animal Health, Bet Dagan, State of Israel.
      samuel.abramson@mail.huji.ac.il
LA  - cze
PT  - English Abstract
PT  - Journal Article
TT  - Nove pohledy moderni mediciny na lecbu pomoci kmenovych bunek, jeji prakticke a
      eticke dusledky.
PL  - Czech Republic
TA  - Klin Onkol
JT  - Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti
JID - 9425213
SB  - IM
MH  - Biomedical Research
MH  - Embryonic Stem Cells/*transplantation
MH  - *Ethics
MH  - Humans
MH  - Neoplasms/etiology
MH  - Stem Cell Transplantation/*adverse effects
EDAT- 2010/03/03 06:00
MHDA- 2010/03/17 06:00
CRDT- 2010/03/03 06:00
PHST- 2010/03/03 06:00 [entrez]
PHST- 2010/03/03 06:00 [pubmed]
PHST- 2010/03/17 06:00 [medline]
PST - ppublish
SO  - Klin Onkol. 2010;23(1):10-3.


PMID- 20191801
OWN - NLM
STAT- MEDLINE
DCOM- 20100319
LR  - 20181010
IS  - 0310-057X (Print)
IS  - 0310-057X (Linking)
VI  - 38
IP  - 1
DP  - 2010 Jan
TI  - The ethics of anaesthesia learning curves (comment).
PG  - 208; author reply 208
FAU - Doyle, D J
AU  - Doyle DJ
LA  - eng
PT  - Comment
PT  - Letter
PL  - United States
TA  - Anaesth Intensive Care
JT  - Anaesthesia and intensive care
JID - 0342017
SB  - IM
CON - Anaesth Intensive Care. 2009 Sep;37(5):824-9. PMID: 19775049
MH  - Anesthesiology/*education/*ethics
MH  - Education, Medical/*ethics
MH  - Humans
MH  - Informed Consent
MH  - Risk Assessment
EDAT- 2010/03/03 06:00
MHDA- 2010/03/20 06:00
CRDT- 2010/03/03 06:00
PHST- 2010/03/03 06:00 [entrez]
PHST- 2010/03/03 06:00 [pubmed]
PHST- 2010/03/20 06:00 [medline]
AID - 20090818 [pii]
PST - ppublish
SO  - Anaesth Intensive Care. 2010 Jan;38(1):208; author reply 208.


PMID- 20191764
OWN - NLM
STAT- MEDLINE
DCOM- 20100330
LR  - 20181201
IS  - 0160-7480 (Print)
IS  - 0160-7480 (Linking)
VI  - 40
IP  - 6
DP  - 2010 Feb 8
TI  - Learned the hard way. HealthSouth co-founder lives lesson about complacency on
      fraud, ethics.
PG  - 25
FAU - Beam, Aaron
AU  - Beam A
AD  - HealthSouth Corp., Birmingham, Alabama, USA.
LA  - eng
PT  - Journal Article
PT  - Legal Case
PL  - United States
TA  - Mod Healthc
JT  - Modern healthcare
JID - 7801798
MH  - Alabama
MH  - Compensation and Redress/*legislation & jurisprudence
MH  - Fraud/*legislation & jurisprudence
MH  - Hospital Administrators/*ethics/legislation & jurisprudence
EDAT- 2010/03/03 06:00
MHDA- 2010/03/31 06:00
CRDT- 2010/03/03 06:00
PHST- 2010/03/03 06:00 [entrez]
PHST- 2010/03/03 06:00 [pubmed]
PHST- 2010/03/31 06:00 [medline]
PST - ppublish
SO  - Mod Healthc. 2010 Feb 8;40(6):25.


PMID- 20191455
OWN - NLM
STAT- MEDLINE
DCOM- 20100521
LR  - 20100301
IS  - 0393-5590 (Print)
IS  - 0393-5590 (Linking)
VI  - 27
IP  - 1
DP  - 2010 Jan-Feb
TI  - [Are there differences in the treatment of kidney patients if they are admitted
      to general medicine vs nephrology units? Yes, and they are significant].
PG  - 10-9
AB  - The care provided by a nephrologist is fundamental because the nephrologist is
      able to prevent, recognize and treat the many and complex factors of comorbidity 
      inherent in chronic kidney disease at its various stages. The nephrologist also
      has the important task of delaying the start of dialysis for as long as possible.
      Delaying dialysis slightly, even just one year for each patient, will have
      ethical, social and economic advantages that should be duly weighed and carefully
      evaluated when adopting organizational models of care involving nephrology. The
      nephrologist bases his work on the clinical competence acquired and maintained
      through appropriate training programs based on CME courses and, above all, daily 
      clinical practice that, in order to be truly educational, must reach a sufficient
      volume of activity to guarantee the best possible outcome to the patient.
FAU - Quintaliani, Giuseppe
AU  - Quintaliani G
AD  - Coordinatore Commissione Organizzazione Servizi Nefrologia, Dialisi e Trapianto
      della Societa Italiana di Nefrologia. quintaliani@yahoo.it
FAU - Gambirasio, Cristina
AU  - Gambirasio C
FAU - Strippoli, Giovanni
AU  - Strippoli G
LA  - ita
PT  - English Abstract
PT  - Journal Article
TT  - Ci sono differenze nel trattamento del nefropatico se il paziente e ricoverato in
      medicina o in nefrologia? Si le differenze sono notevoli.
PL  - Italy
TA  - G Ital Nefrol
JT  - Giornale italiano di nefrologia : organo ufficiale della Societa italiana di
      nefrologia
JID - 9426434
SB  - IM
CIN - G Ital Nefrol. 2010 Jan-Feb;27(1):20-5. PMID: 20191456
CIN - G Ital Nefrol. 2010 Jan-Feb;27(1):26-9. PMID: 20191457
MH  - Clinical Competence/*standards
MH  - Evidence-Based Medicine
MH  - Hemodialysis Units, Hospital/standards
MH  - Hospital Units/organization & administration
MH  - Humans
MH  - *Internal Medicine/standards
MH  - Italy
MH  - Kidney Diseases/therapy
MH  - Kidney Failure, Chronic/diagnosis/mortality/*therapy
MH  - Needs Assessment/standards
MH  - *Nephrology/standards
MH  - *Physician's Role
MH  - Quality of Health Care/standards
MH  - Renal Dialysis/*standards
MH  - Risk Assessment
MH  - Survival Analysis
MH  - Time Factors
EDAT- 2010/03/02 06:00
MHDA- 2010/05/22 06:00
CRDT- 2010/03/02 06:00
PHST- 2010/03/02 06:00 [entrez]
PHST- 2010/03/02 06:00 [pubmed]
PHST- 2010/05/22 06:00 [medline]
PST - ppublish
SO  - G Ital Nefrol. 2010 Jan-Feb;27(1):10-9.


PMID- 20191065
OWN - NLM
STAT- MEDLINE
DCOM- 20100527
LR  - 20211020
IS  - 2005-8330 (Electronic)
IS  - 1229-6929 (Linking)
VI  - 11
IP  - 2
DP  - 2010 Mar-Apr
TI  - The adjacent vessel sign on breast MRI: new data and a subgroup analysis for
      1,084 histologically verified cases.
PG  - 178-86
LID - 10.3348/kjr.2010.11.2.178 [doi]
AB  - OBJECTIVE: The adjacent vessel sign (AVS) is a descriptor for differentiating
      malignant from benign breast lesions on breast MRI (bMRI). This investigation was
      designed to verify the previous reports on the diagnostic accuracy of AVS and to 
      assess correlation between AVS, histopathological diagnosis, lesion size and
      lesion grade. MATERIALS AND METHODS: This study was approved by the local ethical
      committee. Experienced radiologists evaluated 1,084 lesions. The exclusion
      criteria were no histological verification after bMRI and breast interventions
      that were done up to one year before bMRI (surgery, core biopsy, chemo- or
      radiation therapy). The native and dynamic contrast-enhanced T1-weighted series
      were acquired using standardized protocols. The AVS was rated positive if a
      vessel leading to a lesion could be visualized. Prevalence of an AVS was
      correlated with the lesions' size, grade and histology using Chi-square-tests.
      RESULTS: The AVS was significantly associated with malignancy (p < 0.001;
      sensitivity: 47%, specificity: 88%, positive-predictive-value [PPV]: 85%).
      Malignant lesions > 2 cm more often presented with an AVS than did those
      malignant lesions < 2 cm (p < 0.0001; sensitivity: 65%, PPV: 90%). There was no
      correlation of the AVS with the tumor grade. The prevalence of an AVS didn't
      significantly differ between invasive lobular carcinomas versus ductal
      carcinomas. In situ cancers were less frequently associated with an AVS (p <
      0.001). CONCLUSION: The adjacent vessel sign was significantly associated with
      malignancy. Thus, it can be used to accurately assess breast lesions on bMRI. In 
      this study, the AVS was particularly associated with advanced and invasive
      carcinomas.
FAU - Dietzel, Matthias
AU  - Dietzel M
AD  - Institute of Diagnostic and Interventional Radiology,
      Friedrich-Schiller-University Jena, Erlanger Allee 101, D-07740 Jena, Germany.
      matthias.dietzel@med.uni-jena.de
FAU - Baltzer, Pascal A T
AU  - Baltzer PA
FAU - Vag, Tibor
AU  - Vag T
FAU - Herzog, Aimee
AU  - Herzog A
FAU - Gajda, Mieczyslaw
AU  - Gajda M
FAU - Camara, Oumar
AU  - Camara O
FAU - Kaiser, Werner A
AU  - Kaiser WA
LA  - eng
PT  - Journal Article
DEP - 20100222
PL  - Korea (South)
TA  - Korean J Radiol
JT  - Korean journal of radiology
JID - 100956096
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Breast/*pathology
MH  - Breast Neoplasms/*pathology
MH  - Contrast Media
MH  - Diagnosis, Differential
MH  - Female
MH  - Gadolinium DTPA
MH  - Humans
MH  - Image Enhancement/methods
MH  - Magnetic Resonance Imaging/*methods
MH  - Middle Aged
MH  - Neoplasms, Ductal, Lobular, and Medullary/*pathology
MH  - Observer Variation
MH  - Predictive Value of Tests
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Young Adult
PMC - PMC2827781
OTO - NOTNLM
OT  - Breast, MR
OT  - Contrast media
OT  - Descriptor
OT  - Histology
OT  - Neoangiogenesis
OT  - Sign
EDAT- 2010/03/02 06:00
MHDA- 2010/05/28 06:00
CRDT- 2010/03/02 06:00
PHST- 2009/07/14 00:00 [received]
PHST- 2009/11/02 00:00 [accepted]
PHST- 2010/03/02 06:00 [entrez]
PHST- 2010/03/02 06:00 [pubmed]
PHST- 2010/05/28 06:00 [medline]
AID - 10.3348/kjr.2010.11.2.178 [doi]
PST - ppublish
SO  - Korean J Radiol. 2010 Mar-Apr;11(2):178-86. doi: 10.3348/kjr.2010.11.2.178. Epub 
      2010 Feb 22.


PMID- 20190697
OWN - NLM
STAT- MEDLINE
DCOM- 20100512
LR  - 20110614
IS  - 1643-3750 (Electronic)
IS  - 1234-1010 (Linking)
VI  - 16
IP  - 3
DP  - 2010 Mar
TI  - Afghanistan, poppies, and the global pain crisis.
PG  - RA49-57
AB  - The World Health Organization has reported that somewhere between 30-86 million
      people suffer from moderate to severe pain due to cancer, HIV/AIDS, burns, wounds
      and other illnesses annually and do not have access to proper opiate anesthetics 
      to control the pain [1]. The vast majority of these people live in poor nations
      where medicinal opiates are either too expensive or not readily available. In
      this paper, it is argued that access to adequate healthcare is a human right and 
      that adequate healthcare includes management of pain. The solution to this
      problem may be in Afghanistan, a country now overwhelmed with poverty and war.
      Afghanistan is the world's leading producer of heroin. The increase in heroin
      production in Afghanistan has caused the United States and the international
      community to begin to eradicate Afghanistan's poppy fields leading to increased
      poverty among poppy farmers. This paper proposed a paradigm that can be
      implemented in Afghanistan which would allow for Afghan farmers to continue
      growing their poppy crop for medicinal opiates like morphine for poor nations.
      The paradigm covers all parameters of medicinal opiates production including
      licensing, security, cultivation, harvest, and factory production of medicinal
      opiates. The paradigm proposed is less expensive than eradication, brings honest 
      income to Afghan farmers and the new Afghan nation, and can eventually lead to
      Afghanistan acquiring a respectable role in the world community. In closing, a
      full ethical analysis of the paradigm is included to justify the arguments made
      in the paper.
FAU - Clark, Peter A
AU  - Clark PA
AD  - Saint Joseph's University, 5600 City Avenue, Philadelphia, Pennsylvania 19131,
      USA. pclark@sju.edu
FAU - Sillup, George P
AU  - Sillup GP
FAU - Capo, Joseph A
AU  - Capo JA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and
      clinical research
JID - 9609063
RN  - 8008-60-4 (Opium)
SB  - IM
MH  - Afghanistan
MH  - Agriculture
MH  - Ethics, Medical
MH  - Humans
MH  - Licensure/legislation & jurisprudence
MH  - Opium/economics/therapeutic use
MH  - Pain/*drug therapy
MH  - Papaver/*growth & development
EDAT- 2010/03/02 06:00
MHDA- 2010/05/13 06:00
CRDT- 2010/03/02 06:00
PHST- 2010/03/02 06:00 [entrez]
PHST- 2010/03/02 06:00 [pubmed]
PHST- 2010/05/13 06:00 [medline]
AID - 878451 [pii]
PST - ppublish
SO  - Med Sci Monit. 2010 Mar;16(3):RA49-57.


PMID- 20190596
OWN - NLM
STAT- MEDLINE
DCOM- 20100525
LR  - 20171116
IS  - 1533-4112 (Electronic)
IS  - 1095-0680 (Linking)
VI  - 26
IP  - 1
DP  - 2010 Mar
TI  - The depiction of electroconvulsive therapy in Hindi cinema.
PG  - 16-22
LID - 10.1097/YCT.0b013e3181d017ba [doi]
AB  - BACKGROUND: There is little literature on the depiction of electroconvulsive
      therapy (ECT) in movies. In India, Hindi cinema is an important source of public 
      information and misinformation about ECT. METHODS: We identified depictions of
      ECT in Hindi cinema through inquiries with e-communities, video libraries, and
      other sources. We also searched the PubMed database using search terms related to
      ECT and movies. RESULTS: Between 1967 and 2008, 13 Hindi movies contained
      referrals to or depictions of ECT. By and large, the depictions were inaccurate, 
      distorted, and dramatized. Electroconvulsive therapy was administered to punish, 
      to obliterate identity, to induce insanity, and for other rarely clinically valid
      indications. Electroconvulsive therapy was almost always administered by force.
      Premedication was rare. Genuine ECT devices were uncommonly used.
      Electroconvulsive therapy stimulation almost invariably appeared to cause pain.
      Multiple shocks were frequently delivered in the same session. The convulsions
      were usually bizarre. The treatment caused mental disturbance, amnesia, weakness,
      and even a zombielike state, thought not mortality; clinical improvement was
      rare. There was no pattern of increasing accuracy of depiction of ECT with
      recency of movie release. DISCUSSION: We examine the extent to which the
      identified inaccuracies are practically important and offer reasons for the
      inaccuracies. Although the inaccuracies are a cause for concern, we suggest that 
      because Hindi cinema is generally hyperbolic, the public may be willing to
      distinguish real life from reel life when facing clinical decisions about ECT.
      Nevertheless, considering the potential for harm in the dissemination of
      misinformation, filmmakers should exhibit a greater sense of ethics when creating
      impressions that might adversely influence health.
FAU - Andrade, Chittaranjan
AU  - Andrade C
AD  - Department of Psychopharmacology, National Institute of Mental Health and
      Neurosciences, Bangalore. andrade@nimhans.kar.nic.in
FAU - Shah, Nilesh
AU  - Shah N
FAU - Venkatesh, Basappa K
AU  - Venkatesh BK
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J ECT
JT  - The journal of ECT
JID - 9808943
SB  - IM
MH  - Adult
MH  - Antisocial Personality Disorder/psychology/therapy
MH  - Child
MH  - Child Abuse, Sexual
MH  - Depressive Disorder/psychology/therapy
MH  - Drama
MH  - *Electroconvulsive Therapy/adverse effects
MH  - Emotions
MH  - Female
MH  - Hospitals, Psychiatric
MH  - Humans
MH  - India
MH  - Language
MH  - Male
MH  - Memory Disorders/psychology/therapy
MH  - Mental Disorders/psychology/therapy
MH  - Motion Pictures/*statistics & numerical data
MH  - Personality Disorders/psychology/therapy
MH  - Premedication
MH  - Schizophrenia, Paranoid/psychology/therapy
EDAT- 2010/03/02 06:00
MHDA- 2010/05/26 06:00
CRDT- 2010/03/02 06:00
PHST- 2010/03/02 06:00 [entrez]
PHST- 2010/03/02 06:00 [pubmed]
PHST- 2010/05/26 06:00 [medline]
AID - 10.1097/YCT.0b013e3181d017ba [doi]
AID - 00124509-201003000-00006 [pii]
PST - ppublish
SO  - J ECT. 2010 Mar;26(1):16-22. doi: 10.1097/YCT.0b013e3181d017ba.


PMID- 20190057
OWN - NLM
STAT- MEDLINE
DCOM- 20100608
LR  - 20211020
IS  - 1527-974X (Electronic)
IS  - 1067-5027 (Linking)
VI  - 17
IP  - 2
DP  - 2010 Mar-Apr
TI  - The inadvertent disclosure of personal health information through peer-to-peer
      file sharing programs.
PG  - 148-58
LID - 10.1136/jamia.2009.000232 [doi]
AB  - OBJECTIVE: There has been a consistent concern about the inadvertent disclosure
      of personal information through peer-to-peer file sharing applications, such as
      Limewire and Morpheus. Examples of personal health and financial information
      being exposed have been published. We wanted to estimate the extent to which
      personal health information (PHI) is being disclosed in this way, and compare
      that to the extent of disclosure of personal financial information (PFI). DESIGN:
      After careful review and approval of our protocol by our institutional research
      ethics board, files were downloaded from peer-to-peer file sharing networks and
      manually analyzed for the presence of PHI and PFI. The geographic region of the
      IP addresses was determined, and classified as either USA or Canada. MEASUREMENT:
      We estimated the proportion of files that contain personal health and financial
      information for each region. We also estimated the proportion of search terms
      that return files with personal health and financial information. We ascertained 
      and discuss the ethical issues related to this study. RESULTS: Approximately 0.4%
      of Canadian IP addresses had PHI, as did 0.5% of US IP addresses. There was more 
      disclosure of financial information, at 1.7% of Canadian IP addresses and 4.7% of
      US IP addresses. An analysis of search terms used in these file sharing networks 
      showed that a small percentage of the terms would return PHI and PFI files (ie,
      there are people successfully searching for PFI and PHI on the peer-to-peer file 
      sharing networks). CONCLUSION: There is a real risk of inadvertent disclosure of 
      PHI through peer-to-peer file sharing networks, although the risk is not as large
      as for PFI. Anyone keeping PHI on their computers should avoid installing file
      sharing applications on their computers, or if they have to use such tools,
      actively manage the risks of inadvertent disclosure of their, their family's,
      their clients', or patients' PHI.
FAU - El Emam, Khaled
AU  - El Emam K
AD  - Department of Pediatrics, Faculty of Medicine, University of Ottawa, Ottawa,
      Ontario, Canada. kelemam@uottawa.ca
FAU - Neri, Emilio
AU  - Neri E
FAU - Jonker, Elizabeth
AU  - Jonker E
FAU - Sokolova, Marina
AU  - Sokolova M
FAU - Peyton, Liam
AU  - Peyton L
FAU - Neisa, Angelica
AU  - Neisa A
FAU - Scassa, Teresa
AU  - Scassa T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Am Med Inform Assoc
JT  - Journal of the American Medical Informatics Association : JAMIA
JID - 9430800
SB  - IM
MH  - Canada
MH  - *Computer Communication Networks
MH  - Computer Security
MH  - *Confidentiality
MH  - Disclosure
MH  - *Electronic Health Records
MH  - Humans
MH  - *Information Dissemination
MH  - Information Storage and Retrieval
MH  - Risk Management
MH  - United States
PMC - PMC3000774
EDAT- 2010/03/02 06:00
MHDA- 2010/06/09 06:00
CRDT- 2010/03/02 06:00
PHST- 2010/03/02 06:00 [entrez]
PHST- 2010/03/02 06:00 [pubmed]
PHST- 2010/06/09 06:00 [medline]
AID - 17/2/148 [pii]
AID - 10.1136/jamia.2009.000232 [doi]
PST - ppublish
SO  - J Am Med Inform Assoc. 2010 Mar-Apr;17(2):148-58. doi: 10.1136/jamia.2009.000232.


PMID- 20189519
OWN - NLM
STAT- MEDLINE
DCOM- 20100527
LR  - 20100301
IS  - 1097-6779 (Electronic)
IS  - 0016-5107 (Linking)
VI  - 71
IP  - 3
DP  - 2010 Mar
TI  - Succinylated gelatin substantially increases en bloc resection size in colonic
      EMR: a randomized, blinded trial in a porcine model.
PG  - 589-95
LID - 10.1016/j.gie.2009.10.033 [doi]
AB  - BACKGROUND: Succinylated gelatin (SG) is an inexpensive colloid that may combine 
      ease of use with the advantages of a colloid to potentially increase EMR specimen
      size, leading to a higher rate of en bloc resection. OBJECTIVE: To evaluate the
      safety, efficacy, and impact on EMR specimen size of SG as a submucosal (s.m.)
      injectant in comparison with normal saline solution (NS). DESIGN: Randomized,
      blinded, controlled trial conducted with Animal Ethics Committee approval.
      SETTING: Academic hospital. SUBJECTS: Ten swine. INTERVENTIONS: Sixty EMRs (30
      using SG vs 30 using NS as 3 paired experiments per animal) of the largest
      possible en bloc snare resection of normal colonic mucosa after s.m. injection of
      a fixed volume of either SG or NS. MAIN OUTCOME MEASUREMENTS: EMR specimen size, 
      duration of s.m. cushion, duration of procedure, ratio of vertical elevation to
      lateral spread of injectant, ease of resection, adverse effects, perforation,
      histopathology of EMR sites in colectomy specimens at necropsy (for inflammatory 
      cell content, depth of ulceration, and vascular or ischemic changes). RESULTS:
      The mean subject weight was 53 kg. The mean EMR specimen dimensions and surface
      area were significantly larger with SG (length 37 vs 31 mm, P = .031; width 32 vs
      26 mm, P = .022; surface area 9.5 cm(2) vs 6.7 cm(2), P = .044, respectively).
      The median s.m. cushion duration was 60 minutes with SG versus 15 minutes with NS
      (P = .005). The median procedure duration with SG was 2.6 minutes vs 2.5 minutes 
      with NS (P = .515). The ratio of vertical elevation to lateral spread of
      injectant (mean score on a 3-point scale) was 3 with SG versus 2 with NS (P =
      .228). Ease of resection score (mean score on a 10-point scale) was 8 with SG
      versus 7 with NS (P = .216). There were no systemic adverse effects,
      hypersensitivity reactions, or bleeding episodes. There were 2 perforations
      (treated with clips) with SG and 1 with NS (P = 1.0). Blinded histopathologist
      assessment of necropsy colectomy specimens did not identify any significant
      differences between SG and NS EMR sites. LIMITATIONS: Animal study. CONCLUSIONS: 
      SG is safe and results in a 42% increased surface area for en bloc EMR. Given its
      other favorable properties, it represents a significant step toward defining the 
      ideal EMR solution.
CI  - 2010 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc.
      All rights reserved.
FAU - Moss, Alan
AU  - Moss A
AD  - Department of Gastroenterology and Hepatology, Westmead Hospital, Sydney,
      Australia.
FAU - Bourke, Michael J
AU  - Bourke MJ
FAU - Kwan, Vu
AU  - Kwan V
FAU - Tran, Kayla
AU  - Tran K
FAU - Godfrey, Craig
AU  - Godfrey C
FAU - McKay, Gary
AU  - McKay G
FAU - Hopper, Andrew D
AU  - Hopper AD
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Gastrointest Endosc
JT  - Gastrointestinal endoscopy
JID - 0010505
RN  - 0 (Plasma Substitutes)
RN  - 0 (Succinates)
RN  - 39340-57-3 (succinylated gelatin)
RN  - 9000-70-8 (Gelatin)
RN  - 9015-56-9 (Polygeline)
SB  - IM
MH  - Animals
MH  - Colon/*surgery
MH  - Endoscopy, Gastrointestinal/methods
MH  - Gelatin/*pharmacology
MH  - Intestinal Mucosa/*surgery
MH  - Models, Animal
MH  - Plasma Substitutes/*pharmacology
MH  - Polygeline/*pharmacology
MH  - Succinates/*pharmacology
MH  - Swine
EDAT- 2010/03/02 06:00
MHDA- 2010/05/28 06:00
CRDT- 2010/03/02 06:00
PHST- 2009/05/17 00:00 [received]
PHST- 2009/10/14 00:00 [accepted]
PHST- 2010/03/02 06:00 [entrez]
PHST- 2010/03/02 06:00 [pubmed]
PHST- 2010/05/28 06:00 [medline]
AID - S0016-5107(09)02687-X [pii]
AID - 10.1016/j.gie.2009.10.033 [doi]
PST - ppublish
SO  - Gastrointest Endosc. 2010 Mar;71(3):589-95. doi: 10.1016/j.gie.2009.10.033.


PMID- 20189455
OWN - NLM
STAT- MEDLINE
DCOM- 20110103
LR  - 20100430
IS  - 1472-6491 (Electronic)
IS  - 1472-6483 (Linking)
VI  - 20
IP  - 5
DP  - 2010 May
TI  - Saviour embryos? Preimplantation genetic diagnosis as a therapeutic technology.
PG  - 667-74
LID - 10.1016/j.rbmo.2009.12.015 [doi]
AB  - The creation of 'saviour siblings' is one of the most controversial uses of
      preimplantation genetic diagnosis (PGD). This paper outlines and invites ethical 
      discussion of an extension of this technology, namely, the creation of 'saviour
      embryos' to serve as a source of stem cells to be used in potentially life-saving
      therapy for an existing child. A number of analogies between this hypothetical
      use of PGD and existing uses of IVF are offered and, in addition, between saviour
      embryos and proposed therapeutic applications of stem cell technology. The
      ethical significance of a number of disanalogies between these cases are explored
      and investigated. While the creation of saviour embryos would involve a
      significant shift in the rationale for IVF and PGD, it is suggested here that the
      urgent need of an existing individual should be prioritised over any obligations 
      that might exist in relation to the creation or destruction of human embryos.
CI  - Copyright (c) 2009 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All
      rights reserved.
FAU - Sparrow, Robert
AU  - Sparrow R
AD  - Centre for Human Bioethics, Faculty of Arts, Monash University, Vic 3800,
      Australia. Robert.Sparrow@arts.monash.edu.au
FAU - Cram, David
AU  - Cram D
LA  - eng
PT  - Journal Article
DEP - 20091216
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
SB  - IM
CIN - Reprod Biomed Online. 2010 May;20(5):569-71. PMID: 20378413
MH  - Female
MH  - Humans
MH  - Pregnancy
MH  - *Preimplantation Diagnosis
MH  - *Siblings
EDAT- 2010/03/02 06:00
MHDA- 2011/01/05 06:00
CRDT- 2010/03/02 06:00
PHST- 2009/05/14 00:00 [received]
PHST- 2009/06/16 00:00 [revised]
PHST- 2009/11/30 00:00 [accepted]
PHST- 2010/03/02 06:00 [entrez]
PHST- 2010/03/02 06:00 [pubmed]
PHST- 2011/01/05 06:00 [medline]
AID - S1472-6483(09)00292-2 [pii]
AID - 10.1016/j.rbmo.2009.12.015 [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2010 May;20(5):667-74. doi: 10.1016/j.rbmo.2009.12.015.
      Epub 2009 Dec 16.


PMID- 20189279
OWN - NLM
STAT- MEDLINE
DCOM- 20100428
LR  - 20100326
IS  - 1523-6838 (Electronic)
IS  - 0272-6386 (Linking)
VI  - 55
IP  - 4
DP  - 2010 Apr
TI  - Multiple listing in kidney transplantation.
PG  - 717-25
LID - 10.1053/j.ajkd.2009.11.022 [doi]
AB  - The increasing number of patients with end-stage renal disease and the expanding 
      waiting lists for various solid-organ transplants, particularly kidney
      transplants, has compelled prospective transplant recipients and their care teams
      to explore novel ways to accelerate this process, initiating the practice of
      multiple listing. Multiple listing is defined as being listed for an organ
      transplant at more than 1 transplant center. Current policy allows patients to be
      listed at more than 1 transplant center in 1 or more organ procurement
      organization. Multiple listing can be beneficial for different groups of
      transplant candidates. Current data support a beneficial effect for the patient
      on multiple waiting lists, most notably portending a survival advantage for
      transplant recipients. The kidney transplant list has the most patients who are
      multiply listed (4.7%), followed by the liver transplant list at 3.8%. The main
      potential downside of multiple listing is its effect on patients not on multiple 
      lists, as well as the cost accrued to achieve multiple listings. With the newly
      clarified policy of the United Network for Organ Sharing, a pivotal role for
      nephrologists in educating patients about the option of multiple listing becomes 
      more apparent. In this article, current practices and policies regarding multiple
      listing are reviewed and opinions and ethics relating to the practice are
      discussed.
CI  - Copyright 2010 National Kidney Foundation, Inc. Published by Elsevier Inc. All
      rights reserved.
FAU - Sanaei Ardekani, Mohammad
AU  - Sanaei Ardekani M
AD  - Section of Nephrology, Washington Hospital Center, Washington, DC, USA.
FAU - Orlowski, Janis M
AU  - Orlowski JM
LA  - eng
PT  - Journal Article
DEP - 20100226
PL  - United States
TA  - Am J Kidney Dis
JT  - American journal of kidney diseases : the official journal of the National Kidney
      Foundation
JID - 8110075
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - *Kidney Transplantation/statistics & numerical data
MH  - Male
MH  - Middle Aged
MH  - Tissue Donors/statistics & numerical data
MH  - Tissue and Organ Procurement/methods
MH  - *Waiting Lists
MH  - Young Adult
EDAT- 2010/03/02 06:00
MHDA- 2010/04/29 06:00
CRDT- 2010/03/02 06:00
PHST- 2009/07/22 00:00 [received]
PHST- 2009/11/10 00:00 [accepted]
PHST- 2010/03/02 06:00 [entrez]
PHST- 2010/03/02 06:00 [pubmed]
PHST- 2010/04/29 06:00 [medline]
AID - S0272-6386(09)01654-0 [pii]
AID - 10.1053/j.ajkd.2009.11.022 [doi]
PST - ppublish
SO  - Am J Kidney Dis. 2010 Apr;55(4):717-25. doi: 10.1053/j.ajkd.2009.11.022. Epub
      2010 Feb 26.


PMID- 20189137
OWN - NLM
STAT- MEDLINE
DCOM- 20100519
LR  - 20220321
IS  - 1542-2011 (Electronic)
IS  - 1526-9523 (Linking)
VI  - 55
IP  - 2
DP  - 2010 Mar-Apr
TI  - Frozen hope: fertility preservation for women with cancer.
PG  - 175-80
LID - 10.1016/j.jmwh.2009.07.009 [doi]
AB  - Young women diagnosed with cancer have the option of preserving their fertility
      by using assisted reproductive technology (ART) techniques prior to undergoing
      cancer treatment. This article presents a composite case of a young woman with
      cancer who had many unanswered emotional and ethical questions about her future
      as a parent. Fertility preservation techniques, including preimplantation genetic
      diagnosis (PGD), and related patient education are described. Current literature 
      regarding reproductive counseling for cancer survivors is reviewed. Resources for
      providing psychosocial support for decisions about fertility preservation are
      lagging behind the rapid pace of scientific advancements in cancer treatment and 
      ART. As more young women are surviving cancer and taking steps to preserve
      fertility, there is great need for the provision of psychologic support services 
      and the establishment of ethical guidelines to aid them on this path. Women's
      health care providers can provide support to cancer survivors facing fertility
      and parenting issues by becoming knowledgeable about the long-term aspects of
      decision making and developing educational materials and guidelines for these
      patients.
FAU - Quinn, Gwendolyn P
AU  - Quinn GP
AD  - Moffitt Cancer Center - USF Health Outcomes, 12902 Magnolia Drive, MRC CANCONT,
      Tampa, FL 33612, USA. gwen.quinn@moffitt.org
FAU - Vadaparampil, Susan T
AU  - Vadaparampil ST
FAU - Jacobsen, Paul B
AU  - Jacobsen PB
FAU - Knapp, Caprice
AU  - Knapp C
FAU - Keefe, David L
AU  - Keefe DL
FAU - Bell, Geri E
AU  - Bell GE
CN  - Moffitt Fertility Preservation Group
LA  - eng
PT  - Case Reports
PT  - Clinical Conference
PT  - Journal Article
PL  - United States
TA  - J Midwifery Womens Health
JT  - Journal of midwifery & women's health
JID - 100909407
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Adult
MH  - Antineoplastic Agents/*adverse effects/therapeutic use
MH  - Breast Neoplasms/*complications/drug therapy/genetics/psychology
MH  - Cryopreservation
MH  - Female
MH  - Fertility/drug effects/physiology
MH  - Genetic Counseling
MH  - Humans
MH  - Infertility/etiology/*prevention & control/*psychology
MH  - Patient Education as Topic
MH  - *Reproductive Techniques, Assisted/ethics/psychology
EDAT- 2010/03/02 06:00
MHDA- 2010/05/21 06:00
CRDT- 2010/03/02 06:00
PHST- 2009/03/01 00:00 [received]
PHST- 2009/07/23 00:00 [revised]
PHST- 2009/07/23 00:00 [accepted]
PHST- 2010/03/02 06:00 [entrez]
PHST- 2010/03/02 06:00 [pubmed]
PHST- 2010/05/21 06:00 [medline]
AID - S1526-9523(09)00232-3 [pii]
AID - 10.1016/j.jmwh.2009.07.009 [doi]
PST - ppublish
SO  - J Midwifery Womens Health. 2010 Mar-Apr;55(2):175-80. doi:
      10.1016/j.jmwh.2009.07.009.


PMID- 20188850
OWN - NLM
STAT- MEDLINE
DCOM- 20100617
LR  - 20220129
IS  - 1878-5832 (Electronic)
IS  - 1359-6446 (Linking)
VI  - 15
IP  - 7-8
DP  - 2010 Apr
TI  - Stem cells and cell lines from the human auditory organ: applications, hurdles
      and bottlenecks in the development of regenerative therapies for deafness.
PG  - 283-6
LID - 10.1016/j.drudis.2010.02.006 [doi]
AB  - The development of any stem-cell-based therapy (and a potential one for deafness 
      is no exception) relies on the generation of the necessary tools: 'cell drugs'
      that can be safely manufactured for their clinical application. An increasing
      body of work has focussed on the identification, in animal models, of potential
      stem cell sources that could have an application for regenerative therapy in the 
      auditory organ. A still more circumscribed effort--owing to ethical and technical
      difficulties--aims to obtain the actual potential therapeutic candidates (i.e.
      stem cells of human origin). A recently isolated population of human fetal
      auditory stem cells could become an ideal model for some of the challenges lying 
      ahead regarding cochlear stem cell purification, expansion and maintenance.
CI  - 2010 Elsevier Ltd. All rights reserved.
FAU - Rivolta, Marcelo N
AU  - Rivolta MN
AD  - Centre for Stem Cell Biology, University of Sheffield, Sheffield S102TN, UK.
      m.n.rivolta@sheffield.ac.uk
LA  - eng
GR  - G34/ACT_/RNID/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100225
PL  - England
TA  - Drug Discov Today
JT  - Drug discovery today
JID - 9604391
RN  - 0 (Membrane Proteins)
SB  - IM
MH  - Animals
MH  - Cell Line
MH  - Cell Survival
MH  - Cochlea/cytology
MH  - Deafness/*therapy
MH  - Drug Evaluation, Preclinical
MH  - Ear, Inner/*cytology
MH  - Humans
MH  - Membrane Proteins/metabolism
MH  - Signal Transduction/physiology
MH  - Stem Cell Transplantation/*trends
MH  - Stem Cells/*physiology
RF  - 48
EDAT- 2010/03/02 06:00
MHDA- 2010/06/18 06:00
CRDT- 2010/03/02 06:00
PHST- 2009/07/17 00:00 [received]
PHST- 2010/02/15 00:00 [revised]
PHST- 2010/02/18 00:00 [accepted]
PHST- 2010/03/02 06:00 [entrez]
PHST- 2010/03/02 06:00 [pubmed]
PHST- 2010/06/18 06:00 [medline]
AID - S1359-6446(10)00062-0 [pii]
AID - 10.1016/j.drudis.2010.02.006 [doi]
PST - ppublish
SO  - Drug Discov Today. 2010 Apr;15(7-8):283-6. doi: 10.1016/j.drudis.2010.02.006.
      Epub 2010 Feb 25.


PMID- 20188635
OWN - NLM
STAT- MEDLINE
DCOM- 20101019
LR  - 20211020
IS  - 1552-5279 (Electronic)
IS  - 1552-5260 (Linking)
VI  - 6
IP  - 4
DP  - 2010 Jul
TI  - Deliberative assessment of surrogate consent in dementia research.
PG  - 342-50
LID - 10.1016/j.jalz.2009.06.001 [doi]
AB  - BACKGROUND: Research involving incapacitated persons with dementia entails
      complex scientific, legal, and ethical issues, making traditional surveys of
      layperson views on the ethics of such research challenging. We therefore assessed
      the impact of democratic deliberation (DD), involving balanced, detailed
      education and peer deliberation, on the views of those responsible for persons
      with dementia. METHODS: One hundred and seventy-eight community-recruited
      caregivers or primary decision-makers for persons with dementia were randomly
      assigned to either an all-day DD session group or a control group. Educational
      materials used for the DD session were vetted for balance and accuracy by an
      interdisciplinary advisory panel. We assessed the acceptability of
      family-surrogate consent for dementia research ("surrogate-based research") from 
      a societal policy perspective as well as from the more personal perspectives of
      deciding for a loved one or for oneself (surrogate and self-perspectives),
      assessed at baseline, immediately post-DD session, and 1 month after DD date, for
      four research scenarios of varying risk-benefit profiles. RESULTS: At baseline, a
      majority in both the DD and control groups supported a policy of family consent
      for dementia research in all research scenarios. The support for a policy of
      family consent for surrogate-based research increased in the DD group, but not in
      the control group. The change in the DD group was maintained 1 month later. In
      the DD group, there were transient changes in attitudes from surrogate or
      self-perspectives. In the control group, there were no changes from baseline in
      attitude toward surrogate consent from any perspective. CONCLUSIONS: Intensive,
      balanced, and accurate education, along with peer deliberation provided by
      democratic deliberation, led to a sustained increase in support for a societal
      policy of family consent in dementia research among those responsible for
      dementia patients.
CI  - Copyright 2010 The Alzheimer
FAU - Kim, Scott Y H
AU  - Kim SY
AD  - Bioethics Program, University of Michigan, Ann Arbor, MI, USA. scottkim@umich.edu
FAU - Uhlmann, Rebecca A
AU  - Uhlmann RA
FAU - Appelbaum, Paul S
AU  - Appelbaum PS
FAU - Knopman, David S
AU  - Knopman DS
FAU - Kim, H Myra
AU  - Kim HM
FAU - Damschroder, Laura
AU  - Damschroder L
FAU - Beattie, Elizabeth
AU  - Beattie E
FAU - Struble, Laura
AU  - Struble L
FAU - De Vries, Raymond
AU  - De Vries R
LA  - eng
GR  - R01 AG029550/AG/NIA NIH HHS/United States
GR  - R01 AG029550-01A1/AG/NIA NIH HHS/United States
GR  - R01-AG029550/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100226
PL  - United States
TA  - Alzheimers Dement
JT  - Alzheimer's & dementia : the journal of the Alzheimer's Association
JID - 101231978
RN  - 0 (Alzheimer Vaccines)
SB  - IM
MH  - Aged
MH  - Alzheimer Vaccines/therapeutic use
MH  - Attitude
MH  - Data Collection
MH  - Decision Making
MH  - Dementia/*diagnosis/*psychology/therapy
MH  - *Ethics, Research
MH  - Female
MH  - Genetic Therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Randomized Controlled Trials as Topic
MH  - Socioeconomic Factors
MH  - Spinal Puncture
MH  - Surveys and Questionnaires
MH  - *Third-Party Consent
PMC - PMC2889138
MID - NIHMS125657
EDAT- 2010/03/02 06:00
MHDA- 2010/10/20 06:00
CRDT- 2010/03/02 06:00
PHST- 2009/02/11 00:00 [received]
PHST- 2009/05/08 00:00 [revised]
PHST- 2009/06/05 00:00 [accepted]
PHST- 2010/03/02 06:00 [entrez]
PHST- 2010/03/02 06:00 [pubmed]
PHST- 2010/10/20 06:00 [medline]
AID - S1552-5260(09)02055-X [pii]
AID - 10.1016/j.jalz.2009.06.001 [doi]
PST - ppublish
SO  - Alzheimers Dement. 2010 Jul;6(4):342-50. doi: 10.1016/j.jalz.2009.06.001. Epub
      2010 Feb 26.


PMID- 20188506
OWN - NLM
STAT- MEDLINE
DCOM- 20110307
LR  - 20191210
IS  - 1873-5134 (Electronic)
IS  - 0738-3991 (Linking)
VI  - 78
IP  - 3
DP  - 2010 Mar
TI  - From patient compliance to empowerment and consumer's choice: evolution or
      regression? An overview of patient education in French speaking European
      countries.
PG  - 282-7
LID - 10.1016/j.pec.2010.01.012 [doi]
AB  - OBJECTIVE: This paper presents a historical overview of patient education in
      French speaking (parts of) countries of Europe, as well as the emergence of new
      concepts in Health care and education. Further it describes the results of
      research and studies on current practice and political decisions and positions
      about patient education, based upon laws and regulations. The present trends will
      be discussed, and propose an overview of the next possible developmental steps.
      METHODS: Articles, reports and policy documents about publications on patient
      education in French speaking (parts of) countries of Europe. RESULTS: In the last
      years, in France, Belgium, Switzerland, Luxemburg, patient education has
      undergone a lot of changes whether in theories, models, policies or practice.
      These changes came with the emergence of concepts such as effectiveness of care, 
      chronic disease follow-up, compliance, adherence, health promotion, empowerment, 
      salutogenesis, resilience, patients' rights, health care costs control, coaching,
      disease management, consumer choice, and participation. Each of these concepts
      seems to have been defined and implemented in various ways, according to settings
      or countries. Political and social choices seem to have oriented choices from
      humanistic approaches to pragmatic decisions, with ethical problems rising.
      Consensus on definitions are often hard to reach, especially among policy makers,
      health care teams, health managers, and patient organizations, even though these 
      concepts do coexist in daily practice, sometimes in very conflictual ways.
      CONCLUSIONS: Hard or subtle, changes are happening in patient education and
      cannot be ignored. PRACTICE IMPLICATION: Many questions rise on the future of
      patient education, wondering how to anticipate next models of health care
      practice, and their ethical and social stakes. Clear positions need to be taken.
CI  - Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Deccache, Alain
AU  - Deccache A
AD  - Health and Patient Education Unit (UCL-IRSS-RESO), Universite catholique de
      Louvain, 1200 Brussels, Belgium. Alain.deccache@uclouvain.be
FAU - van Ballekom, Karin
AU  - van Ballekom K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100225
PL  - Ireland
TA  - Patient Educ Couns
JT  - Patient education and counseling
JID - 8406280
MH  - *Communication
MH  - *Decision Making
MH  - Disease Management
MH  - Ethics, Medical
MH  - France
MH  - Health Promotion
MH  - Humans
MH  - Language
MH  - *Patient Compliance
MH  - *Patient Education as Topic
MH  - Patient Participation
MH  - *Patient Satisfaction
MH  - Physician-Patient Relations
MH  - *Power, Psychological
RF  - 30
EDAT- 2010/03/02 06:00
MHDA- 2011/03/08 06:00
CRDT- 2010/03/02 06:00
PHST- 2009/09/25 00:00 [received]
PHST- 2010/01/19 00:00 [revised]
PHST- 2010/01/19 00:00 [accepted]
PHST- 2010/03/02 06:00 [entrez]
PHST- 2010/03/02 06:00 [pubmed]
PHST- 2011/03/08 06:00 [medline]
AID - S0738-3991(10)00021-2 [pii]
AID - 10.1016/j.pec.2010.01.012 [doi]
PST - ppublish
SO  - Patient Educ Couns. 2010 Mar;78(3):282-7. doi: 10.1016/j.pec.2010.01.012. Epub
      2010 Feb 25.


PMID- 20188370
OWN - NLM
STAT- MEDLINE
DCOM- 20101126
LR  - 20100809
IS  - 1873-491X (Electronic)
IS  - 0020-7489 (Linking)
VI  - 47
IP  - 9
DP  - 2010 Sep
TI  - Involvement of hospital nurses in care decisions related to administration of
      artificial nutrition or hydration (ANH) in patients with dementia: a qualitative 
      study.
PG  - 1105-16
LID - 10.1016/j.ijnurstu.2010.01.011 [doi]
AB  - BACKGROUND: Nurses that care for patients with advanced dementia are increasingly
      faced with consequences of disease progression, often requiring them to decide
      whether to artificially feed these patients. Clarifying how nurses can be better 
      supported in complex care processes involving ethically sensitive decision-making
      requires that their practice be mapped out. OBJECTIVES: The aims of this study
      were to explore and describe how nurses are involved in the care that surrounds
      decisions concerning artificial nutrition or hydration in hospitalized patients
      with dementia. DESIGN: We used a qualitative interview design. Data collection
      and analysis were informed by the grounded theory approach. SETTING: Nine
      hospitals geographically spread throughout the five provinces of Flanders,
      Belgium. PARTICIPANTS: Twenty-one nurses were purposively selected for interview,
      with the aim of including nurses that reflected diverse personal characteristics 
      and experiences with the subject matter. METHODS: Between April 2008 and June
      2009, we conducted 21 interviews that were audiotaped and later transcribed. Data
      processing involved (1) simultaneous and systematic data collection and analysis,
      (2) constant forwards-backwards wave, (3) continuous dialogue with the data, and 
      (4) interactive team processes. RESULTS: Nurses' involvement was characterized by
      a desire to provide 'good care', which was the basis for their motivation and
      aspiration during the care process. Early in the process, nurses developed a
      holistic picture of their patients, laying the foundation of their 'good care'
      view. During the actual decision-making, nurses fulfilled the roles of messengers
      and guiding communicators, as they attempted to realize their 'good care' view.
      Nurses judged the physicians' decisions in light of their care view. If a
      decision matched their view, they supported the decision. If not, they resisted
      it openly or covertly. Some nurses remained passively in the background, while
      others took action to override the decision. Nurses' involvement ended with the
      intensive aftercare of the patients and their family. CONCLUSIONS: Nurses are
      closely and continuously involved in the care that surrounds decisions concerning
      artificial nutrition or hydration in hospitalized patients with advanced
      dementia. During the care process, nurses play several and specific roles, giving
      their contribution a unique and variable character.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Bryon, Els
AU  - Bryon E
AD  - Centre for Biomedical Ethics and Law, Catholic University of Leuven,
      Kapucijnenvoer 35/3, B-3000 Leuven, Belgium. els.bryon@med.kuleuven.be
FAU - Gastmans, Chris
AU  - Gastmans C
FAU - Dierckx de Casterle, Bernadette
AU  - Dierckx de Casterle B
LA  - eng
PT  - Journal Article
DEP - 20100225
PL  - England
TA  - Int J Nurs Stud
JT  - International journal of nursing studies
JID - 0400675
SB  - IM
MH  - Adult
MH  - Aged
MH  - Belgium
MH  - *Decision Making
MH  - Dementia/*nursing
MH  - *Feeding Methods
MH  - Female
MH  - *Fluid Therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Nursing Staff, Hospital
MH  - Qualitative Research
EDAT- 2010/03/02 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/03/02 06:00
PHST- 2009/11/20 00:00 [received]
PHST- 2010/01/15 00:00 [revised]
PHST- 2010/01/31 00:00 [accepted]
PHST- 2010/03/02 06:00 [entrez]
PHST- 2010/03/02 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S0020-7489(10)00051-9 [pii]
AID - 10.1016/j.ijnurstu.2010.01.011 [doi]
PST - ppublish
SO  - Int J Nurs Stud. 2010 Sep;47(9):1105-16. doi: 10.1016/j.ijnurstu.2010.01.011.
      Epub 2010 Feb 25.


PMID- 20188055
OWN - NLM
STAT- MEDLINE
DCOM- 20100608
LR  - 20100301
IS  - 0767-0974 (Print)
IS  - 0767-0974 (Linking)
VI  - 26
IP  - 2
DP  - 2010 Feb
TI  - [Ethical issues raised by 2 kinds of protocols for organ donation after cardiac
      death: aspects particular to France, Spain and the United States].
PG  - 209-13
LID - 10.1051/medsci/2010262209 [doi]
AB  - France, Spain and US are three leader countries in activity of organ procurement 
      and transplantation. Donation after cardiac death is one of the strategies they
      have been implemented in order to face organ shortage. Donation after cardiac
      death is internationally considered to be an encouraging source of organs for
      transplantation both because of its capacity to significantly increase the donor 
      pool and because of the quality of the organs obtained from non-heart-beating
      organ donors. These protocols give rise to important ethical issues that have
      been widely discussed in the international literature. The aim of this paper is
      to identify and discuss the ethical issues that these protocols raise in these
      three countries.
FAU - Tortosa, Jean-Christophe
AU  - Tortosa JC
AD  - Laboratoire d'ethique medicale et de medecine legale, Universite Paris Descartes,
      Centre universitaire des Saints-Peres, 75006 Paris, France. jc.tortosa@free.fr
FAU - Rodriguez-Arias Vailhen, David
AU  - Rodriguez-Arias Vailhen D
FAU - Moutel, Gregoire
AU  - Moutel G
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Questions ethiques soulevees par les deux types de protocoles de prelevements
      d'organes a coeur arrete: aspects particuliers a la France, l'Espagne et aux
      Etats-Unis.
PL  - France
TA  - Med Sci (Paris)
JT  - Medecine sciences : M/S
JID - 8710980
SB  - IM
MH  - Advance Care Planning
MH  - Brain Death/diagnosis
MH  - Cardiopulmonary Resuscitation
MH  - *Death
MH  - France
MH  - Heart Arrest
MH  - Humans
MH  - Informed Consent/legislation & jurisprudence
MH  - Organ Preservation
MH  - Spain
MH  - Third-Party Consent/legislation & jurisprudence
MH  - Tissue Donors
MH  - Tissue and Organ Procurement/*ethics/legislation & jurisprudence
MH  - United States
RF  - 30
EDAT- 2010/03/02 06:00
MHDA- 2010/06/09 06:00
CRDT- 2010/03/02 06:00
PHST- 2010/03/02 06:00 [entrez]
PHST- 2010/03/02 06:00 [pubmed]
PHST- 2010/06/09 06:00 [medline]
AID - 00/00/0E/FF/ [pii]
AID - 10.1051/medsci/2010262209 [doi]
PST - ppublish
SO  - Med Sci (Paris). 2010 Feb;26(2):209-13. doi: 10.1051/medsci/2010262209.


PMID- 29783324
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1744-828X (Electronic)
IS  - 1741-0541 (Linking)
VI  - 7
IP  - 2
DP  - 2010 Mar
TI  - Integrating genomic-based clinical decision support into electronic health
      records.
PG  - 163-170
LID - 10.2217/pme.09.73 [doi]
AB  - There is a growing consensus that the first and most necessary step to improving 
      the efficiency, cost-effectiveness and quality of healthcare systems can be
      achieved through the implementation of interoperable patient-centric electronic
      health record (EHR) systems across hospitals and clinics. Targeted therapeutics
      (including screening, prevention and disease management) through EHR-based
      clinical decision support delivery may drive both the acceptance and adoption of 
      EHR systems by providing personalized information at the point-of-care. The
      realization of targeted therapeutics will depend on the resolution of current
      political, ethical, socioeconomical and technical challenges surrounding EHR
      implementation efforts. There is a growing need for broad-based consensus
      initiatives to foster an essential level of standardization for EHRs. The
      timeliness of these issues is underlined by the rapid emergence of private sector
      efforts in this potentially lucrative field, from direct-to-consumer testing to
      Google-, or Microsoft-owned personal health data. This review discusses the
      potential value for adopting healthcare technology, with a focus on personalized 
      medicine, and highlights the challenges that remain to achieve this.
FAU - Al Mallah, Amr
AU  - Al Mallah A
AD  - Genome Quebec & Montreal Heart Institute Pharmacogenomics Centre, 5000 rue
      Belanger, Montreal, Quebec H1T 1C8, Canada. tvanrooij@pgx.ca.
FAU - Guelpa, Paul
AU  - Guelpa P
AD  - Genome Quebec & Montreal Heart Institute Pharmacogenomics Centre, 5000 rue
      Belanger, Montreal, Quebec H1T 1C8, Canada. tvanrooij@pgx.ca.
FAU - Marsh, Sharon
AU  - Marsh S
AD  - Genome Quebec & Montreal Heart Institute Pharmacogenomics Centre, 5000 rue
      Belanger, Montreal, Quebec H1T 1C8, Canada. tvanrooij@pgx.ca.
AD  - Faculty of Pharmacy & Pharmaceutical Sciences, University of Alberta, AB, Canada.
FAU - van Rooij, Tibor
AU  - van Rooij T
AD  - Genome Quebec & Montreal Heart Institute Pharmacogenomics Centre, 5000 rue
      Belanger, Montreal, Quebec H1T 1C8, Canada. tvanrooij@pgx.ca.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Per Med
JT  - Personalized medicine
JID - 101238549
OTO - NOTNLM
OT  - clinical decision support
OT  - direct-to-consumer testing
OT  - electronic health
OT  - electronic health record
OT  - genomics
OT  - personal health record
OT  - personalized medicine
OT  - point-of-care
OT  - standardization
OT  - targeted therapeutics
EDAT- 2010/03/01 00:00
MHDA- 2010/03/01 00:01
CRDT- 2018/05/23 06:00
PHST- 2018/05/23 06:00 [entrez]
PHST- 2010/03/01 00:00 [pubmed]
PHST- 2010/03/01 00:01 [medline]
AID - 10.2217/pme.09.73 [doi]
PST - ppublish
SO  - Per Med. 2010 Mar;7(2):163-170. doi: 10.2217/pme.09.73.


PMID- 27393075
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160712
LR  - 20160709
IS  - 0040-5957 (Print)
IS  - 0040-5957 (Linking)
VI  - 65
IP  - 2
DP  - 2010 Mar-Apr
TI  - [Not Available].
PG  - 71-94
LID - 10.2515/therapie/2010006 [doi]
LID - S0040-5957(16)30662-X [pii]
AB  - Since the full implementation in France of the European Directive 2001/20/EC
      about biomedical research, a written information form must be given to any
      participant in research, who must give in return his / her written consent. The
      written and consent form must be validated by a referent ethics committees prior 
      to the research, but guidelines for the redaction of such document are missing.
      Thus, the investigators who are often in charge of the redaction could be helped 
      by a tutorial that may consider the legal aspects, the rights of the participant 
      and the quality of information. For this, a group from the French network of the 
      clinical investigation centres - directed by the Inserm - worked on a tutorial
      which is presented here. This tutorial has been built stepwise, with review of
      the literature, enquiry within the French clinical investigation centres, primary
      redaction, internal validation, and final validation by external experts versed
      in the field of ethics for biomedical research.
CI  - Copyright (c) 2010 Societe Francaise de Pharmacologie et de Therapeutique. Publie
      par Elsevier Masson SAS.
FAU - Henin, Yvette
AU  - Henin Y
AD  - Inserm CIC BT 505, Paris, France; APHP, Groupe Cochin-Pasteur, Paris, France.
FAU - Boischevalier, Benedicte de
AU  - Boischevalier Bd
AD  - Inserm, Departement de Recherche Clinique et Therapeutique, Paris, France;
      Inserm, Comite de Qualification Institutionnel, Paris, France.
FAU - Reboul-Salze, Francoise
AU  - Reboul-Salze F
AD  - Inserm, Mission Inserm Associations, Paris, France.
FAU - Cracowski, Jean-Luc
AU  - Cracowski JL
AD  - Inserm CIC 003, CHU, Grenoble, France; CHU, Pharmacologie, Grenoble, France;
      Universite Joseph Fourier, Grenoble, France; Comite de Protection des Personnes
      Sud-Est V, CHU de Grenoble, Grenoble, France; Comite d'Ethique des CIC de l'Inter
      Region Rhone Alpes Auvergne, Clermont-Ferrand, France.
FAU - Duale, Christian
AU  - Duale C
AD  - Comite d'Ethique des CIC de l'Inter Region Rhone Alpes Auvergne,
      Clermont-Ferrand, France; Inserm CIC 501, Clermont-Ferrand, France; CHU, Centre
      Pharmacologique Clinique, Clermont-Ferrand, France. Electronic address:
      cduale@chu-clermontferrand.fr.
CN  - pour le Groupe de Travail << Ethique >> du Reseau National des Centres
      d'Investigation Clinique
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Aide a la redaction du document ecrit destine a l'information du participant a la
      Recherche BioMedicale et a l'attestation de son consentement eclaire.
PL  - France
TA  - Therapie
JT  - Therapie
JID - 0420544
OTO - NOTNLM
OT  - Recherche BioMedicale
OT  - biomedical research
OT  - clinical research
OT  - consentement eclaire
OT  - information
OT  - informed consent
OT  - participant
OT  - recherche clinique
OT  - redaction
OT  - redaction
EDAT- 2010/03/01 00:00
MHDA- 2010/03/01 00:01
CRDT- 2016/07/10 06:00
PHST- 2009/09/28 00:00 [received]
PHST- 2009/12/22 00:00 [accepted]
PHST- 2016/07/10 06:00 [entrez]
PHST- 2010/03/01 00:00 [pubmed]
PHST- 2010/03/01 00:01 [medline]
AID - S0040-5957(16)30662-X [pii]
AID - 10.2515/therapie/2010006 [doi]
PST - ppublish
SO  - Therapie. 2010 Mar-Apr;65(2):71-94. doi: 10.2515/therapie/2010006.


PMID- 27320278
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160621
LR  - 20160620
IS  - 1472-0795 (Print)
IS  - 1472-0795 (Linking)
VI  - 22
IP  - 2
DP  - 2010 Mar 1
TI  - Caring for older people in the community Angela Hudson and Lesley Moore (Eds)
      Caring for older people in the community Wiley-Blackwell pound26.99 264pp
      9780470518045 9780470518045 [Formula: see text].
PG  - 12
LID - 10.7748/nop.22.2.12.s18 [doi]
AB  - DELIVERED in three sections that focus on the care of older people over time,
      this book begins with past and current influences on practice, moves to
      contemporary challenges and ends by discussing the challenges for the future.
      Through this format it provides nurses with a theoretical understanding of the
      sociological, ethical and demographic background for community nursing of older
      people which proceeds to relate to the practice challenges of today.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Older People
JT  - Nursing older people
JID - 101084156
EDAT- 2010/03/01 00:00
MHDA- 2010/03/01 00:01
CRDT- 2016/06/21 06:00
PHST- 2016/06/21 06:00 [entrez]
PHST- 2010/03/01 00:00 [pubmed]
PHST- 2010/03/01 00:01 [medline]
AID - 10.7748/nop.22.2.12.s18 [doi]
PST - ppublish
SO  - Nurs Older People. 2010 Mar 1;22(2):12. doi: 10.7748/nop.22.2.12.s18.


PMID- 26761757
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160115
LR  - 20160114
IS  - 1679-4508 (Print)
IS  - 1679-4508 (Linking)
VI  - 8
IP  - 1
DP  - 2010 Mar
TI  - Communication difficulties and strategies used by the nurses and their team in
      caring for the hearing impaired.
PG  - 80-5
LID - 10.1590/S1679-45082010AO1339 [doi]
LID - S1679-45082010000100080 [pii]
AB  - OBJECTIVES: To identify communication difficulties faced by the nursing staff and
      to learn the strategies developed for non-oral communication. METHODS: This is a 
      descriptive, exploratory, level I study with a quantitative approach. The sample 
      group comprised 37 registered nurses and 63 licensed practical nurses of a
      private hospital who, after undergoing the ethical-legal procedures, answered a
      questionnaire to identify difficulties faced and strategies used in the care for 
      hearing-impaired patients. RESULTS: Difficulty in explaining matters of interest 
      to the patient was reported by 66% of professionals; and 32% reported
      difficulties in understanding patients in their way of communicate. The strategy 
      adopted by 100% of respondents was mimicry, followed by lip reading, used by 94% 
      of respondents; help from a person accompanying the patient was used by 65%, and 
      written communication by 42% of respondents. Only 1% used communication via the
      Brazilian Sign Language (LIBRAS). CONCLUSIONS: The difficulties found and the
      strategies adopted by the nursing staff in communicating with hearing-impaired
      patients justify the need to train these professionals to deliver a more
      humanized care, developing a more inclusive society for those with special needs.
FAU - Britto, Fernanda da Rocha
AU  - Britto Fda R
AD  - Hospital Israelita Albert Einstein - HIAE, Sao Paulo, SP, Brazil.
FAU - Samperiz, Maria Mercedes Fernandez
AU  - Samperiz MM
AD  - Faculdade de Enfermagem, Hospital Israelita Albert Einstein - HIAE, Sao Paulo,
      SP, Brazil.
LA  - eng
LA  - por
PT  - Journal Article
PL  - Brazil
TA  - Einstein (Sao Paulo)
JT  - Einstein (Sao Paulo, Brazil)
JID - 101281800
EDAT- 2010/03/01 00:00
MHDA- 2010/03/01 00:01
CRDT- 2016/01/14 06:00
PHST- 2009/05/14 00:00 [received]
PHST- 2009/12/18 00:00 [accepted]
PHST- 2016/01/14 06:00 [entrez]
PHST- 2010/03/01 00:00 [pubmed]
PHST- 2010/03/01 00:01 [medline]
AID - S1679-45082010000100080 [pii]
AID - 10.1590/S1679-45082010AO1339 [doi]
PST - ppublish
SO  - Einstein (Sao Paulo). 2010 Mar;8(1):80-5. doi: 10.1590/S1679-45082010AO1339.


PMID- 26761756
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160115
LR  - 20160114
IS  - 1679-4508 (Print)
IS  - 1679-4508 (Linking)
VI  - 8
IP  - 1
DP  - 2010 Mar
TI  - A mobile interventional radiology unit: innovation and social responsibility.
PG  - 75-9
LID - 10.1590/S1679-45082010AO1468 [doi]
LID - S1679-45082010000100075 [pii]
AB  - OBJECTIVE: To present the preliminary results of a feasibility study performed to
      determine the value of a mobile interventional radiology unit used to promote a
      uterine embolization program for low-income patients. METHODS: Forty patients
      with symptomatic fibroids were treated with uterine embolization. Procedures were
      performed in four public hospitals in the metropolitan area of Sao Paulo. This
      study was approved by the institutional research ethics committee and all
      patients signed an informed consent form. A mobile interventional radiology unit,
      named ANGIOMOVEL, was conceived and implemented utilizing a small truck to
      transport one mobile C arm, one radiological table, protection aprons and a small
      trolley containing specific supplies for the procedures. The ANGIOMOVEL team
      consisted of two interventional radiologists, one nurse, one driver and one
      assistant. The unit visited one hospital per week during a three-month period.
      Patient inclusion was contingent upon several factors, such as evaluation by a
      trained gynecologist, completion of a pelvic MRI, routine serological laboratory 
      tests and completion of a quality of life questionnaire (QOL). Outcomes, MRI and 
      QOL were evaluated. Data obtained after 12 weeks were collected and analyzed.
      RESULTS: Technical success was achieved in 100% of cases, with a mean procedure
      time of 43 minutes and a mean fluoroscopic time of 24 minutes. The mean hospital 
      stay was 1.07 day and the mean time for recovery and return to normal activities 
      was 10 days. After 12 weeks, 36 (90%) of patients noticed improvement of their
      symptoms and 4 (10%) did not notice any improvement. Thirty-eight patients (95%) 
      were satisfied or very satisfied and 39 (97.5%) said they would recommend the
      procedure. Pre- and post-procedure magnetic resonance imaging analysis showed
      that complete fibroid ischemia was achieved in 92.5% of cases with a mean uterine
      volume reduction of 38% and a mean fibroid volume reduction of 52%.
      Health-related quality of life scores showed improvement, increasing from 39.30
      before the treatment to 79.62 points after therapy. CONCLUSIONS: The initial
      results indicate that using a Mobile Interventional Radiology Unit is feasible,
      efficient and safe to develop a successful uterine fibroid embolization program
      providing care to the underserved patient community.
FAU - Kisilevzky, Nestor Hugo
AU  - Kisilevzky NH
AD  - Hospital Israelita Albert Einstein - HIAE, Sao Paulo, SP, Brazil.
FAU - Elkis, Henrique
AU  - Elkis H
AD  - Hospital Israelita Albert Einstein - HIAE, Sao Paulo, SP, Brazil.
FAU - Gusmao, Francielle Aparecida
AU  - Gusmao FA
AD  - Instituto Israelita de Responsabilidade Social Albert Einstein - HIAE, Sao Paulo,
      SP, Brazil.
LA  - eng
LA  - por
PT  - Journal Article
PL  - Brazil
TA  - Einstein (Sao Paulo)
JT  - Einstein (Sao Paulo, Brazil)
JID - 101281800
EDAT- 2010/03/01 00:00
MHDA- 2010/03/01 00:01
CRDT- 2016/01/14 06:00
PHST- 2009/06/14 00:00 [received]
PHST- 2009/12/12 00:00 [accepted]
PHST- 2016/01/14 06:00 [entrez]
PHST- 2010/03/01 00:00 [pubmed]
PHST- 2010/03/01 00:01 [medline]
AID - S1679-45082010000100075 [pii]
AID - 10.1590/S1679-45082010AO1468 [doi]
PST - ppublish
SO  - Einstein (Sao Paulo). 2010 Mar;8(1):75-9. doi: 10.1590/S1679-45082010AO1468.


PMID- 26162128
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150714
LR  - 20150711
IS  - 1745-6916 (Print)
IS  - 1745-6916 (Linking)
VI  - 5
IP  - 2
DP  - 2010 Mar
TI  - In Favor of Clear Thinking: Incorporating Moral Rules Into a Wise Cost-Benefit
      Analysis-Commentary on Bennis, Medin, & Bartels (2010).
PG  - 209-12
LID - 10.1177/1745691610362362 [doi]
AB  - Bennis, Medin, and Bartels (2010, this issue) have contributed an interesting
      article on the comparative benefit of moral rules versus cost-benefit analysis
      (CBA). Many of their specific comments are accurate, useful, and insightful. At
      the same time, we believe they have misrepresented CBA and have reached a set of 
      conclusions that are misguided and, if adopted wholesale, potentially dangerous. 
      Overall, they offer wise suggestions for making CBA more effective, rather than
      eliminating CBA as a decision-making tool.
CI  - (c) The Author(s) 2010.
FAU - Bazerman, Max H
AU  - Bazerman MH
AD  - Harvard Business School, Harvard University, Cambridge, MA mbazerman@hbs.edu.
FAU - D Greene, Joshua
AU  - D Greene J
AD  - Department of Psychology, Harvard University, Cambridge, MA.
LA  - eng
PT  - Journal Article
DEP - 20100330
PL  - United States
TA  - Perspect Psychol Sci
JT  - Perspectives on psychological science : a journal of the Association for
      Psychological Science
JID - 101274347
OTO - NOTNLM
OT  - cost-benefit analysis
OT  - ethics
OT  - morality
OT  - rationality
EDAT- 2010/03/01 00:00
MHDA- 2010/03/01 00:01
CRDT- 2015/07/11 06:00
PHST- 2015/07/11 06:00 [entrez]
PHST- 2010/03/01 00:00 [pubmed]
PHST- 2010/03/01 00:01 [medline]
AID - 5/2/209 [pii]
AID - 10.1177/1745691610362362 [doi]
PST - ppublish
SO  - Perspect Psychol Sci. 2010 Mar;5(2):209-12. doi: 10.1177/1745691610362362. Epub
      2010 Mar 30.


PMID- 24037043
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130917
LR  - 20220408
IS  - 1876-3413 (Print)
IS  - 1876-3405 (Linking)
VI  - 2
IP  - 1
DP  - 2010 Mar
TI  - Conducting operational research within a non governmental organization: the
      example of Medecins Sans Frontieres.
PG  - 1-8
LID - 10.1016/j.inhe.2009.12.008 [doi]
AB  - Like many other non governmental organizations (NGOs) that provide assistance to 
      vulnerable populations living in difficult and resource-limited settings,
      Medecins Sans Frontieres (MSF) is confronted with situations for which proven,
      effective interventions are often lacking and/or where there is need for strong
      advocacy for improving medical care. As a result, MSF has become an important
      contributor to health research, and has dedicated resources to guide operational 
      research by establishing its own Ethics Review Board, an innovation fund, an
      online publications repository and by regularly contributing to major scientific 
      conferences. However, this increased research activity has led to concern that
      priorities and resources may be diverted away from the essential mandate of care 
      provision for NGOs. In response, this article discusses the potential role
      operational research can play within medical NGOs such as MSF, and highlights the
      relevance of operational research, the essential elements of developing it within
      the organisation and some of the perceived barriers and solutions.
FAU - Zachariah, R
AU  - Zachariah R
AD  - Medecins Sans Frontieres, Medical Department (Brussels Operational Centre-
      Operational Research), 68 Rue de Gasperich, L-1617, Luxembourg.
FAU - Ford, N
AU  - Ford N
FAU - Draguez, B
AU  - Draguez B
FAU - Yun, O
AU  - Yun O
FAU - Reid, T
AU  - Reid T
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int Health
JT  - International health
JID - 101517095
EDAT- 2010/03/01 00:00
MHDA- 2010/03/01 00:01
CRDT- 2013/09/17 06:00
PHST- 2013/09/17 06:00 [entrez]
PHST- 2010/03/01 00:00 [pubmed]
PHST- 2010/03/01 00:01 [medline]
AID - j.inhe.2009.12.008 [pii]
AID - 10.1016/j.inhe.2009.12.008 [doi]
PST - ppublish
SO  - Int Health. 2010 Mar;2(1):1-8. doi: 10.1016/j.inhe.2009.12.008.


PMID- 23484443
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130317
LR  - 20130314
IS  - 1753-0059 (Print)
IS  - 1753-0059 (Linking)
VI  - 4
IP  - 2
DP  - 2010 Mar
TI  - Prenatal diagnostics: how to define the boundaries of ethical practice? (A
      patient and family perspective on current issues and possibilities).
PG  - 99-101
LID - 10.1517/17530051003663249 [doi]
FAU - Kent, Alastair
AU  - Kent A
AD  - Genetic Interest Group, London, N1 3QP, UK +44 0 20 7704 3141 ; +44 0 20 7359
      1447 ; alastair@gig.org.uk.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Expert Opin Med Diagn
JT  - Expert opinion on medical diagnostics
JID - 101392201
EDAT- 2010/03/01 00:00
MHDA- 2010/03/01 00:01
CRDT- 2013/03/15 06:00
PHST- 2013/03/15 06:00 [entrez]
PHST- 2010/03/01 00:00 [pubmed]
PHST- 2010/03/01 00:01 [medline]
AID - 10.1517/17530051003663249 [doi]
PST - ppublish
SO  - Expert Opin Med Diagn. 2010 Mar;4(2):99-101. doi: 10.1517/17530051003663249.


PMID- 22581053
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1938-8993 (Electronic)
IS  - 1540-4153 (Linking)
VI  - 8
IP  - 1
DP  - 2010 Mar 1
TI  - Disparidad en Salud: Un Fenomeno Multidimensional.
PG  - 23-35
AB  - La Disparidad en Salud (DS) ha llamado la atencion publica desde el siglo pasado,
      ha sido analizada desde diversas perspectivas y enfoques incluso variados
      terminos han sido utilizados como sinonimos pudiendo llevar a confusion e
      inequidades al momento de su operacionalizacion. Sin embargo es importante
      senalar que las publicaciones coinciden en que la DS es uno de las determinantes 
      esenciales a considerar al momento de definir pollticas publicas. El proposito de
      esta publicacion es analizar la disparidad en salud incorporando; a) los aspectos
      claves de su conceptualizacion, b) la evolucion historica del concepto, c) las
      estrategias que se han generado para enfrentarla, d) los factores considerados
      determinantes, y e) los aspectos eticos y la contribucion de la investigacion en 
      la disminucion de la DS.Health Disparities (HD) have been at the center of public
      attention for the past century. They have been analyzed from diverse perspectives
      utilizing various terms as synonyms that can lead to confusion and inequality at 
      the moment of operationalization. Despite this, it is important to indicate that 
      publications agree that HD are essential determinants that must be considered in 
      the definition of public policy. The objective of this publication is to analyze 
      health disparities incorporating; (a) key aspects in their conceptualization, (b)
      the historic evolution of the concept, (c) strategies that have been generated to
      confront them, (d) determining factors, and (e) ethical aspects and the
      contribution of research in decreasing HD.
FAU - Urrutia, Maria-Teresa
AU  - Urrutia MT
AD  - Pontificia Universidad Catolica de Chile, Escuela de Enfermerla, and University
      of Miami School of Nursing and Health Studies.
FAU - Cianelli, Rosina
AU  - Cianelli R
LA  - eng
GR  - P60 MD002266/MD/NIMHD NIH HHS/United States
GR  - P60 MD002266-03/MD/NIMHD NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Hisp Health Care Int
JT  - Hispanic health care international : the official journal of the National
      Association of Hispanic Nurses
JID - 101150304
PMC - PMC3349157
MID - NIHMS274934
EDAT- 2010/03/01 00:00
MHDA- 2010/03/01 00:01
CRDT- 2012/05/15 06:00
PHST- 2012/05/15 06:00 [entrez]
PHST- 2010/03/01 00:00 [pubmed]
PHST- 2010/03/01 00:01 [medline]
AID - 10.1891/1540-4153.8.1.23 [doi]
PST - ppublish
SO  - Hisp Health Care Int. 2010 Mar 1;8(1):23-35. doi: 10.1891/1540-4153.8.1.23.


PMID- 22457996
OWN - NLM
STAT- MEDLINE
DCOM- 20120503
LR  - 20170203
IS  - 0723-1393 (Print)
IS  - 0723-1393 (Linking)
VI  - 29
IP  - 1
DP  - 2010 Mar
TI  - Research ethics committees and community values: Devlin, Dworkin, Hart and
      beyond.
PG  - 37-50
AB  - Two fundamental requirements ought to be met in any selection to research ethics 
      committees: (i) professional scientific competence, and (ii) the understanding of
      moral values which prevail in any community. The question is: Should the verdicts
      of research ethics committees be based on community values? This article
      critically examines theories of community as were propounded by Devlin, Dworkin
      and Hart in answer to this question. It is argued that community values are
      complementary rather than conflicting, and that Dworkin's theory of community
      provides an analytical framework for research ethics on the new genetic
      technologies. Finally, it is submitted that the verdicts of research ethics
      committees should be based on community values.
FAU - Salako, Solomon E
AU  - Salako SE
AD  - School of Law, Liverpool John Moores University, 98 Mount Pleasant, Liverpool,
      UK.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Law
JT  - Medicine and law
JID - 8218185
SB  - IM
MH  - Ethics Committees, Research/*standards
MH  - *Ethics, Research
MH  - Genetic Engineering/ethics
MH  - Humans
MH  - *Morals
MH  - Residence Characteristics
MH  - *Social Values
EDAT- 2010/03/01 00:00
MHDA- 2012/05/04 06:00
CRDT- 2012/03/31 06:00
PHST- 2012/03/31 06:00 [entrez]
PHST- 2010/03/01 00:00 [pubmed]
PHST- 2012/05/04 06:00 [medline]
PST - ppublish
SO  - Med Law. 2010 Mar;29(1):37-50.


PMID- 22457995
OWN - NLM
STAT- MEDLINE
DCOM- 20120503
LR  - 20170203
IS  - 0723-1393 (Print)
IS  - 0723-1393 (Linking)
VI  - 29
IP  - 1
DP  - 2010 Mar
TI  - How do we care for our future caregivers? Rethinking education in bioethics with 
      regard to professionalism and institutions.
PG  - 21-36
AB  - BACKGROUND: Bioethics is an integral part of most medical curricula. It
      complements medical skills training to help future caregivers make morally good
      decisions in their encounters with patients. Principle-based concepts are
      commonly regarded as the mainstream approach to bioethics in today's world.
      However, despite its clear merits, principlism alone is not sufficient for
      educating future caregivers. Hence, additional perspectives of health care
      education are required and will be taken into account in this paper. OBJECTIVES: 
      Two shortcomings of typical health care training must be addressed: insufficient 
      consideration of the nature of the health care profession and of institutional
      requirements. Notions and relevance of professionalism in health care have been
      intensively discussed in recent years. In this paper, I argue that a caring
      understanding of professionalism is essential for good quality care for the
      patient and for the physicians themselves. With reference to the ethics of care, 
      the scope of caring professionalism and its implications for health care
      education are considered and placed within an analytical framework that combines 
      the individual and the institutional context of health care. CONCLUSIONS: To
      educate our future caregivers, we must address aspects of professionalism more
      intensively in medical and nursing schools, and even more so during residencies. 
      This is not just a task of training in knowledge or competencies, but also
      involves the character formation of the individual and the whole organization.
      Rethinking health care education from this perspective will allow us to answer
      the question 'How do we care for our future caregivers?' with an easier
      conscience.
FAU - Wallner, Jurgen
AU  - Wallner J
AD  - University of Vienna, Institute for Ethics and Law in Medicine.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Law
JT  - Medicine and law
JID - 8218185
SB  - IM
MH  - Bioethics/*education
MH  - Delivery of Health Care/*ethics/standards
MH  - Education, Medical/*standards
MH  - Education, Nursing/*standards
MH  - Ethics, Professional/education
MH  - Humans
EDAT- 2010/03/01 00:00
MHDA- 2012/05/04 06:00
CRDT- 2012/03/31 06:00
PHST- 2012/03/31 06:00 [entrez]
PHST- 2010/03/01 00:00 [pubmed]
PHST- 2012/05/04 06:00 [medline]
PST - ppublish
SO  - Med Law. 2010 Mar;29(1):21-36.


PMID- 22457994
OWN - NLM
STAT- MEDLINE
DCOM- 20120503
LR  - 20211203
IS  - 0723-1393 (Print)
IS  - 0723-1393 (Linking)
VI  - 29
IP  - 1
DP  - 2010 Mar
TI  - Advance directives in the clinical ethics context: an African perspective.
PG  - 11-9
AB  - In this paper I examine issues associated with advance directives and the impact 
      these issues have on people's lives based on their value systems. I ague from an 
      African perspective, where I defend the view that competent persons ought to be
      allowed to decide on medical interventions they want (or do not want) should they
      become incompetent. My arguments are derived from the idea of African concepts of
      death, dying and belief in ancestral realm. The principle of
      collective-autonomous decision is used to explain how decisions on advance
      directives to reject a medical intervention can be implemented in the African
      context.
FAU - Omonzejele, Peter F
AU  - Omonzejele PF
AD  - Department of Philosophy, University Of Benin, Benin-City, Nigeria.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Law
JT  - Medicine and law
JID - 8218185
SB  - IM
MH  - Advance Directives/*ethics/ethnology
MH  - Attitude to Death/*ethnology
MH  - *Blacks
MH  - Decision Making/ethics
MH  - *Ethics, Clinical
MH  - Family Relations/*ethnology
MH  - Humans
MH  - Personal Autonomy
EDAT- 2010/03/01 00:00
MHDA- 2012/05/04 06:00
CRDT- 2012/03/31 06:00
PHST- 2012/03/31 06:00 [entrez]
PHST- 2010/03/01 00:00 [pubmed]
PHST- 2012/05/04 06:00 [medline]
PST - ppublish
SO  - Med Law. 2010 Mar;29(1):11-9.


PMID- 22437358
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130704
LR  - 20120322
IS  - 1556-9845 (Print)
IS  - 1556-9845 (Linking)
VI  - 5
IP  - 2
DP  - 2010 Mar
TI  - Medtentia double helix mitral annuloplasty system evaluated in a porcine
      experimental model.
PG  - 114-7
LID - 10.1097/IMI.0b013e3181d84316 [doi]
AB  - OBJECTIVE: : To further develop and improve minimally invasive surgical
      procedures, dedicated appropriate surgical devices are mandatory. In this study, 
      the safety and feasibility of implanting the novel Medtentia double helix mitral 
      annuloplasty ring, which uses the key-ring principle to potentially allow faster 
      and sutureless implantation, was assessed using both minimally invasive and
      conventional surgical techniques. Because of ethical concerns, a human compatible
      porcine experimental model of mitral valve surgery was used. METHODS: : Twelve
      50-kg pigs were allocated to implantation of the Medtentia double helix
      annuloplasty ring using conventional midline sternotomy including cardioplegic
      arrest or a minimally invasive approach using peripheral cannulation and left
      ventricular fibrillation. Ten weeks after surgery, echocardiography was performed
      to assess mitral valve function. Animals were then killed, and gross mitral valve
      anatomy was examined ex vivo. RESULTS: : All animals survived 10 weeks without
      developing mitral regurgitation, structural leaflet damage, ring dehiscence, or
      endocarditis. In the minimally invasive compared with the midline sternotomy
      group (mean +/- SD), significantly reduced recovery time (80 +/- 16 vs. 327 +/-
      23 minutes, P < 0.01) and a tendency toward increased operating time (199 +/- 33 
      vs. 168 +/- 15 minutes, P > 0.05) and cardiopulmonary bypass time (98 +/- 12 vs. 
      91 +/- 11 minutes, P > 0.05) were observed. CONCLUSIONS: : By using a both
      minimally invasive and conventional midline sternotomy implantation techniques,
      the Medtentia double helix annuloplasty ring showed no mitral valve dysfunction
      or tissue damage 10 weeks postoperatively.
FAU - Jensen, Henrik
AU  - Jensen H
AD  - From the *Department of Cardiothoracic and Vascular Surgery T and Institute of
      Clinical Medicine, Aarhus University Hospital-Skejby, Aarhus, Denmark; and
      daggerDepartment of Cardiothoracic Surgery, Helsinki University Central Hospital,
      Helsinki, Finland.
FAU - Simpanen, Jarmo
AU  - Simpanen J
FAU - Smerup, Morten
AU  - Smerup M
FAU - Bjerre, Marianne
AU  - Bjerre M
FAU - Bramsen, Morten
AU  - Bramsen M
FAU - Werkkala, Kalervo
AU  - Werkkala K
FAU - Vainikka, Tiina
AU  - Vainikka T
FAU - Hasenkam, J Michael
AU  - Hasenkam JM
FAU - Wierup, Per
AU  - Wierup P
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Innovations (Phila)
JT  - Innovations (Philadelphia, Pa.)
JID - 101257528
EDAT- 2010/03/01 00:00
MHDA- 2010/03/01 00:01
CRDT- 2012/03/23 06:00
PHST- 2012/03/23 06:00 [entrez]
PHST- 2010/03/01 00:00 [pubmed]
PHST- 2010/03/01 00:01 [medline]
AID - 10.1097/IMI.0b013e3181d84316 [doi]
AID - 01243895-201003000-00008 [pii]
PST - ppublish
SO  - Innovations (Phila). 2010 Mar;5(2):114-7. doi: 10.1097/IMI.0b013e3181d84316.


PMID- 22402004
OWN - NLM
STAT- MEDLINE
DCOM- 20130930
LR  - 20120309
IS  - 1939-1536 (Electronic)
IS  - 0033-3204 (Linking)
VI  - 47
IP  - 1
DP  - 2010 Mar
TI  - Avoiding the road to ethical disaster: overcoming vulnerabilities and developing 
      resilience.
PG  - 98-110
LID - 10.1037/a0018843 [doi]
AB  - Psychotherapists may, despite their best intentions, find themselves engaging in 
      ethically problematic behaviors that could have been prevented. Drawing on recent
      research in moral psychology and longstanding community mental health approaches 
      to prevention, we suggest that psychotherapists can reduce the likelihood of
      committing ethical infractions (and move in the direction of ethical excellence) 
      by attending carefully to 4 general dimensions: the desire to facilitate positive
      (good) outcomes, the powerful opportunities given to professionals to effect
      change, personal values, and education. Each dimension can foster enhanced
      ethical behavior and personal resilience, but each can also contribute to ethical
      vulnerability. By recognizing and effectively addressing these dimensions,
      psychotherapists can reduce their vulnerabilities, enhance their resilience,
      reduce the risk of ethical infractions, and improve the quality of their work.
CI  - PsycINFO Database Record (c) 2010 APA, all rights reserved
FAU - Tjeltveit, Alan C
AU  - Tjeltveit AC
AD  - Department of Psychology, Muhlenberg College, Allentown, PA 18104, USA.
      tjelt@muhlenberg.edu
FAU - Gottlieb, Michael C
AU  - Gottlieb MC
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Psychotherapy (Chic)
JT  - Psychotherapy (Chicago, Ill.)
JID - 2984829R
SB  - IM
MH  - Health Personnel/*ethics
MH  - Humans
MH  - Mental Disorders/*therapy
MH  - Morals
MH  - Psychotherapy/education/*ethics
MH  - Resilience, Psychological/*ethics
MH  - Social Values
EDAT- 2010/03/01 00:00
MHDA- 2013/10/01 06:00
CRDT- 2012/03/10 06:00
PHST- 2012/03/10 06:00 [entrez]
PHST- 2010/03/01 00:00 [pubmed]
PHST- 2013/10/01 06:00 [medline]
AID - 2010-05168-011 [pii]
AID - 10.1037/a0018843 [doi]
PST - ppublish
SO  - Psychotherapy (Chic). 2010 Mar;47(1):98-110. doi: 10.1037/a0018843.


PMID- 22402001
OWN - NLM
STAT- MEDLINE
DCOM- 20130930
LR  - 20120309
IS  - 1939-1536 (Electronic)
IS  - 0033-3204 (Linking)
VI  - 47
IP  - 1
DP  - 2010 Mar
TI  - Enhancing supervisee reflectivity in clinical supervision: a case study
      illustration.
PG  - 51-67
LID - 10.1037/a0018844 [doi]
AB  - Reflectivity has been described as the cyclical process whereby individuals
      engage in a critical evaluation of their affective, cognitive, and behavioral
      experiences to produce insight and fundamental shifts in their original beliefs. 
      Developing reflectivity in supervisees is one of the most challenging, yet
      important, responsibilities of clinical supervisors, given its link to such
      skills as critical thinking, ethical decision making, and problem solving. This
      paper advances the literature by presenting a case example that demonstrates how 
      reflectivity can be emphasized in clinical supervision, highlighting the barriers
      to reflectivity, and providing strategies that supervisors can utilize to
      encourage reflectivity within clinical supervision. The strategies and
      information discussed may be flexibly applied to supervisees of all developmental
      levels within the context of individual supervision.
CI  - PsycINFO Database Record (c) 2010 APA, all rights reserved
FAU - Orchowski, Lindsay
AU  - Orchowski L
AD  - Department of Psychology, Ohio University, USA. lo305903@ohio.edu
FAU - Evangelista, Nicole M
AU  - Evangelista NM
FAU - Probst, Danielle R
AU  - Probst DR
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Psychotherapy (Chic)
JT  - Psychotherapy (Chicago, Ill.)
JID - 2984829R
SB  - IM
MH  - Adult
MH  - Attitude of Health Personnel
MH  - Clinical Competence
MH  - Communication
MH  - Female
MH  - Humans
MH  - Mental Disorders/*therapy
MH  - Professional-Patient Relations
MH  - Psychotherapy/*education/*organization & administration
MH  - *Self-Assessment
EDAT- 2010/03/01 00:00
MHDA- 2013/10/01 06:00
CRDT- 2012/03/10 06:00
PHST- 2012/03/10 06:00 [entrez]
PHST- 2010/03/01 00:00 [pubmed]
PHST- 2013/10/01 06:00 [medline]
AID - 2010-05168-008 [pii]
AID - 10.1037/a0018844 [doi]
PST - ppublish
SO  - Psychotherapy (Chic). 2010 Mar;47(1):51-67. doi: 10.1037/a0018844.


PMID- 22401996
OWN - NLM
STAT- MEDLINE
DCOM- 20130930
LR  - 20181201
IS  - 1939-1536 (Electronic)
IS  - 0033-3204 (Linking)
VI  - 47
IP  - 1
DP  - 2010 Mar
TI  - Competency in conducting cognitive-behavioral therapy: foundational, functional, 
      and supervisory aspects.
PG  - 12-9
LID - 10.1037/a0018849 [doi]
AB  - The delivery of cognitive-behavioral therapy (CBT) is described in terms of
      foundational and functional competencies, with additional attention paid to how
      these skills are applied in clinical supervision. Foundational competencies
      include such qualities as ethical behavior, good interpersonal relational skills,
      a healthy capacity for self-awareness and self-correction, cross-cultural
      sensitivity, and an appreciation for the empirical basis of clinical procedures. 
      Functional competencies include the ability to think like an empiricist and to
      teach clients to do the same, to conceptualize cases in terms of maladaptive
      beliefs and behavioral patterns, to structure sessions in an organized and
      time-effective manner, and to assign and review homework assignments. CBT
      supervisors have the multiple responsibilities of serving as professional role
      models for their supervisees, nurturing the latter's professional development
      (although also being ready to identify and remediate problems in the supervisee's
      performance), and engaging in ongoing self-improvement and education to function 
      most effectively as clinical mentors. A brief, descriptive supervisory vignette
      is presented.
CI  - PsycINFO Database Record (c) 2010 APA, all rights reserved
FAU - Newman, Cory F
AU  - Newman CF
AD  - Center for Cognitive Therapy, University of Pennsylvania, Philadelphia, PA 19104,
      USA. psydoc@mail.upenn.edu
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Psychotherapy (Chic)
JT  - Psychotherapy (Chicago, Ill.)
JID - 2984829R
SB  - IM
MH  - *Clinical Competence
MH  - Cognitive Behavioral Therapy/*education/methods/*organization & administration
MH  - Cultural Competency/*education/*organization & administration
MH  - Humans
MH  - Mental Disorders/*therapy
MH  - Mentors
MH  - Professional Role
EDAT- 2010/03/01 00:00
MHDA- 2013/10/01 06:00
CRDT- 2012/03/10 06:00
PHST- 2012/03/10 06:00 [entrez]
PHST- 2010/03/01 00:00 [pubmed]
PHST- 2013/10/01 06:00 [medline]
AID - 2010-05168-003 [pii]
AID - 10.1037/a0018849 [doi]
PST - ppublish
SO  - Psychotherapy (Chic). 2010 Mar;47(1):12-9. doi: 10.1037/a0018849.


PMID- 22031986
OWN - NLM
STAT- MEDLINE
DCOM- 20111123
LR  - 20211020
IS  - 1321-2753 (Print)
IS  - 1321-2753 (Linking)
VI  - 29
IP  - 1
DP  - 2010 Mar
TI  - Waiver of informed consent in prehospital emergency health research in Australia.
PG  - 07.1-16
AB  - Informed consent is a vital part of ethical research. In emergency health care
      research environments such as ambulance services and emergency departments, it is
      sometimes necessary to conduct trial interventions or observations without
      patient consent. At times where treatment is time critical, it may be impossible 
      or inappropriate to seek consent from next of kin. Emergency medicine is one of
      the few areas where the process of informed consent can be waived to allow
      research to proceed without patient consent. This article will explore the ethics
      of informed consent in the prehospital emergency research context. This will
      include an overview of current Australian guidelines for ethical research, and
      recent changes in law internationally which have affected the conduct of
      international emergency health research. An overview of the ethical reasoning
      behind the waiver of informed consent in emergency research is presented, also
      addressing issues relating to emergency health research such as proxy consent,
      unconscious patients, and patient decision making capacity. The unusual
      circumstances encountered in the prehospital ambulance environment will also be
      discussed, including the dependent and coercive relationship between patients and
      ambulance professionals, and a lack of alternatives for care and transport for
      patients who refuse consent. The conflict arising from differences in medical
      culture and values between patients and health care professionals will also
      briefly be discussed. It will be argued that, while emergency care research
      should not require informed consent due to the restrictions of time and dependent
      nature of the relationship between patient and health professional, emergency
      health researchers still have a responsibility to consider the patients'
      perspective when considering the ethical issues of an emergency research project,
      particularly in the prehospital environment.
FAU - Morgans, Amee
AU  - Morgans A
AD  - Department of Community Based Emergency Health and Paramedic Practice, Monash
      University. Amee.Morgans@med.monash.edu.au
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Monash Bioeth Rev
JT  - Monash bioethics review
JID - 100973394
SB  - IM
MH  - Australia
MH  - Emergency Medicine/*ethics
MH  - Guidelines as Topic
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Informed Consent/*ethics
EDAT- 2010/03/01 00:00
MHDA- 2011/12/13 00:00
CRDT- 2011/10/29 06:00
PHST- 2011/10/29 06:00 [entrez]
PHST- 2010/03/01 00:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/BF03351323 [doi]
PST - ppublish
SO  - Monash Bioeth Rev. 2010 Mar;29(1):07.1-16. doi: 10.1007/BF03351323.


PMID- 22031985
OWN - NLM
STAT- MEDLINE
DCOM- 20111123
LR  - 20211020
IS  - 1321-2753 (Print)
IS  - 1321-2753 (Linking)
VI  - 29
IP  - 1
DP  - 2010 Mar
TI  - Examining the root cause of surrogate conflicts in the intensive care unit and
      general wards.
PG  - 06.1-11
AB  - This study is an analysis of surrogate-focused ethics consultations in the
      Intensive Care Unit (ICU) and the general wards (Ward) of a large community
      hospital in Northern California. We identified the major themes of
      surrogate-focused ethics consultations to better understand the root cause of
      surrogate conflicts, and identified the similarities and differences between
      surrogate-based conflicts in the two settings. Consults requested because the
      surrogate had desires that conflicted with the physician's medical opinion of
      'best interest', or cases involving surrogates not upholding a patient's known
      values reflected the root cause of the majority of surrogate conflicts (72.7%
      ICU, 83.3% Ward).
FAU - Rubin, Allison Neyhart
AU  - Rubin AN
AD  - California Pacific Medical Center (CPMC), USA. allie.rubin@gmail.com
FAU - Bramstedt, Katrina A
AU  - Bramstedt KA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Monash Bioeth Rev
JT  - Monash bioethics review
JID - 100973394
SB  - IM
MH  - Adult
MH  - Advance Directive Adherence/ethics
MH  - Aged
MH  - Aged, 80 and over
MH  - California
MH  - *Conflict, Psychological
MH  - Decision Making/*ethics
MH  - Ethics Consultation
MH  - Female
MH  - Hospitals, Community
MH  - Humans
MH  - Intensive Care Units
MH  - Male
MH  - Middle Aged
MH  - *Proxy
EDAT- 2010/03/01 00:00
MHDA- 2011/12/13 00:00
CRDT- 2011/10/29 06:00
PHST- 2011/10/29 06:00 [entrez]
PHST- 2010/03/01 00:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/BF03351322 [doi]
PST - ppublish
SO  - Monash Bioeth Rev. 2010 Mar;29(1):06.1-11. doi: 10.1007/BF03351322.


PMID- 22031984
OWN - NLM
STAT- MEDLINE
DCOM- 20111123
LR  - 20151119
IS  - 1321-2753 (Print)
IS  - 1321-2753 (Linking)
VI  - 29
IP  - 1
DP  - 2010 Mar
TI  - "We don't have a crystal ball..." Neonatologists' views on prognosis, magnetic
      resonance imaging and treatment withdrawal for infants with birth asphyxia.
PG  - 05.1-19
AB  - Birth asphyxia is the most common single cause of death in term newborn infants. 
      The majority of deaths in developed countries follow decisions to withdraw
      intensive care. Recent technological advances, particularly the use of magnetic
      resonance imaging (MRI) of the brain, may affect the process of prognostication
      and decision-making. There is little existing evidence about how prognosis is
      determined in newborn infants and how this relates to treatment withdrawal
      decisions. An exploratory qualitative study was performed using in-depth
      semi-structured interviews with a sample of ten neonatologists from tertiary
      intensive care units in the UK. Participants were purposively selected to ensure 
      a range of experience and type of unit. They were asked about the process of
      prognostication for infants with birth asphyxia and decisions about treatment
      withdrawal. Interviews were transcribed and thematically analysed. MRI played a
      significant role in decision-making about life-sustaining treatment for a number 
      of clinicians. Clinicians did not identify particular ethical concerns related to
      MRI, though wider discussion revealed issues relating to uncertainty around
      predictions, the timing of prognostication and decision-making, and difficulty in
      predicting quality of life.
FAU - Wilkinson, Dominic
AU  - Wilkinson D
AD  - The Ethox Centre, Department of Public Health and Primary Health Care, and Oxford
      Uehiro Centre for Practical Ethics, The University of Oxford.
      dominic.wilkinson@ethox.ox.ac.uk
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Monash Bioeth Rev
JT  - Monash bioethics review
JID - 100973394
SB  - IM
MH  - Adult
MH  - Asphyxia Neonatorum/*diagnosis
MH  - England
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Magnetic Resonance Imaging/*ethics
MH  - Male
MH  - Middle Aged
MH  - Practice Patterns, Physicians'/*ethics
MH  - Prognosis
MH  - Quality of Life
MH  - Uncertainty
MH  - Withholding Treatment/*ethics
EDAT- 2010/03/01 00:00
MHDA- 2011/12/13 00:00
CRDT- 2011/10/29 06:00
PHST- 2011/10/29 06:00 [entrez]
PHST- 2010/03/01 00:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PST - ppublish
SO  - Monash Bioeth Rev. 2010 Mar;29(1):05.1-19.


PMID- 21877429
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20170214
IS  - 0957-154X (Print)
IS  - 0957-154X (Linking)
VI  - 21
IP  - 81 Pt 1
DP  - 2010 Mar
TI  - Science and morals in the affective psychopathology of Philippe Pinel.
PG  - 38-53
AB  - Building on what he believed was a new 'medico-philosophical' method, Philippe
      Pinel made a bold theoretical attempt to find a place for the passions and other 
      affective posits in psychopathology. However, his courageous attempt to steer
      affectivity onto the high seas of medical science ran aground on two great reefs 
      that still threaten the scientific status of affectivity today.
      Epistemologically, there is the elusive nature of the signs and symptoms of
      affectivity. Ethically, there is the stubborn manner in which fact and value are 
      intermingled in affectivity. Both obstacles posed insuperable difficulties for
      Pinel, who never really managed to extricate his affective psychopathology from
      the confines of the Lockean intellectual paradigm.
FAU - Charland, Louis C
AU  - Charland LC
AD  - Department of Philosophy, University of Western Ontario, London, Ontario, Canada 
      N6A 3K7. charland@uwo.ca
LA  - eng
PT  - Biography
PT  - Historical Article
PT  - Journal Article
PL  - England
TA  - Hist Psychiatry
JT  - History of psychiatry
JID - 9013819
MH  - *Emotions
MH  - France
MH  - History, 18th Century
MH  - History, 19th Century
MH  - Humans
MH  - Mood Disorders/*history
MH  - *Morals
MH  - Philosophy, Medical/*history
MH  - Psychopathology/*history
MH  - Science/*history
PS  - Pinel P
FPS - Pinel, Philippe
EDAT- 2010/03/01 00:00
MHDA- 2011/09/29 06:00
CRDT- 2011/09/01 06:00
PHST- 2011/09/01 06:00 [entrez]
PHST- 2010/03/01 00:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 10.1177/0957154X09338334 [doi]
PST - ppublish
SO  - Hist Psychiatry. 2010 Mar;21(81 Pt 1):38-53. doi: 10.1177/0957154X09338334.


PMID- 20187197
OWN - NLM
STAT- MEDLINE
DCOM- 20100609
LR  - 20100303
IS  - 1522-2586 (Electronic)
IS  - 1053-1807 (Linking)
VI  - 31
IP  - 3
DP  - 2010 Mar
TI  - Assessment of tumor blood flow in breast tumors with T1-dynamic contrast-enhanced
      MR imaging: impact of dose reduction and the use of a prebolus technique on
      diagnostic efficacy.
PG  - 556-61
LID - 10.1002/jmri.22077 [doi]
AB  - PURPOSE: To prospectively evaluate whether dose reduction and the application of 
      a prebolus technique can effectively alleviate signal saturation effects in T1
      dynamic contrast enhanced (T1-DCE) magnetic resonance imaging (MRI) data in
      breast tumors and lead to increased diagnostic efficacy of the regional tumor
      blood flow (TBF) values obtained with deconvolution of T1-DCE MRI data. MATERIALS
      AND METHODS: After obtaining informed consent, 23 women (32-80 years) with
      histologically proven breast tumors underwent MR mammography that included a
      whole-breast T1 DCE sequence. In the slice where the tumor enhanced maximally, a 
      prebolus protocol was applied. One mL of Gd-DTPA solution at 2 mL/s was injected 
      at the beginning of a dynamic axial single slice inversion-prepared turbo field
      echo acquisition. At the 400th dynamic, a high dose of either 20 mL (15 patients)
      or 10 mL (8 patients) of contrast agent was injected at 2 mL/s and a further 400 
      dynamics were acquired. From the aortic prebolus curve an arterial input function
      (AIF) was reconstructed by time-shifting and adding the prebolus data. The
      relative enhancement time course from the tumor region of interest was
      deconvolved with the reconstructed AIF to generate the impulse response function,
      the maximum of which yielded the TBF. The institutional ethical committee
      approved the study. RESULTS: Reducing the contrast dose by a factor of 2 led to
      an increase in diagnostic contrast for the TBF values of malignant and benign
      tumors by a factor of slightly more than 2. Addition of the prebolus technique
      improved this further by 45%. receiver operating characteristic analysis showed a
      significant increase of diagnostic yield related to the combined use of a
      prebolus and minimal dose. CONCLUSION: Using a prebolus approach provides an
      estimate of the unsaturated AIF, while reduction of the high-dose bolus minimizes
      possible saturation effects in the tumor time course.
FAU - Makkat, Smitha
AU  - Makkat S
AD  - Department of Radiology, UZ Brussel, Vrije Universiteit Brussel, Brussels,
      Belgium. Smitha.Makkat@vub.ac.be
FAU - Luypaert, Robert
AU  - Luypaert R
FAU - Sourbron, Steven
AU  - Sourbron S
FAU - Stadnik, Tadeusz
AU  - Stadnik T
FAU - De Mey, Johan
AU  - De Mey J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Blood Flow Velocity
MH  - Breast Neoplasms/complications/*diagnosis/*physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Neovascularization, Pathologic/*diagnosis/etiology/*physiopathology
MH  - Radiation Dosage
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
EDAT- 2010/02/27 06:00
MHDA- 2010/06/10 06:00
CRDT- 2010/02/27 06:00
PHST- 2010/02/27 06:00 [entrez]
PHST- 2010/02/27 06:00 [pubmed]
PHST- 2010/06/10 06:00 [medline]
AID - 10.1002/jmri.22077 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2010 Mar;31(3):556-61. doi: 10.1002/jmri.22077.


PMID- 20186572
OWN - NLM
STAT- MEDLINE
DCOM- 20101220
LR  - 20211020
IS  - 1572-8633 (Electronic)
IS  - 1386-7423 (Linking)
VI  - 13
IP  - 3
DP  - 2010 Aug
TI  - Moral tales of parental living kidney donation: a parenthood moral imperative and
      its relevance for decision making.
PG  - 225-36
LID - 10.1007/s11019-010-9238-3 [doi]
AB  - Free and informed choice is an oft-acknowledged ethical basis for living kidney
      donation, including parental living kidney donation. The extent to which choice
      is present in parental living kidney donation has, however, been questioned.
      Since parents can be expected to have strong emotional bonds to their children,
      it has been asked whether these bonds make parents unable to say no to this
      donation. This article combines a narrative analysis of parents' stories of
      living kidney donation with a philosophical discussion of conditions for parental
      decision-making. Previous research has shown that parents often conclude that it 
      is "natural" to donate. Our study shows that this naturalness needs to be
      understood as part of a story where parental living kidney donation is regarded
      as natural and as a matter of non-choice. Our study also highlights the presence 
      of a parenthood moral imperative of always putting one's child's needs before
      one's own. On the basis of these results, we discuss conditions for
      decision-making in the context of parental LKD. We argue that the presence of a
      parenthood moral imperative can matter with regard to the decision-making process
      when parents consider whether to volunteer as living kidney donors, but that it
      need not hamper choice. We emphasise the need for exploring relational and
      situational factors in order to understand parental decision-making in the
      context of parental LKD.
FAU - Zeiler, Kristin
AU  - Zeiler K
AD  - Division of Health and Society, Department of Medical and Health Sciences,
      Linkoping University, 581 83, Linkoping, Sweden. Kristin.Zeiler@liu.se
FAU - Guntram, Lisa
AU  - Guntram L
FAU - Lennerling, Anette
AU  - Lennerling A
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Med Health Care Philos
JT  - Medicine, health care, and philosophy
JID - 9815900
SB  - IM
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Decision Making
MH  - Female
MH  - Humans
MH  - Kidney Transplantation/*ethics
MH  - Living Donors/ethics/*psychology
MH  - Male
MH  - *Moral Obligations
MH  - *Parent-Child Relations
MH  - Parents/*psychology
EDAT- 2010/02/27 06:00
MHDA- 2010/12/21 06:00
CRDT- 2010/02/27 06:00
PHST- 2010/02/27 06:00 [entrez]
PHST- 2010/02/27 06:00 [pubmed]
PHST- 2010/12/21 06:00 [medline]
AID - 10.1007/s11019-010-9238-3 [doi]
PST - ppublish
SO  - Med Health Care Philos. 2010 Aug;13(3):225-36. doi: 10.1007/s11019-010-9238-3.


PMID- 20185451
OWN - NLM
STAT- MEDLINE
DCOM- 20100616
LR  - 20100312
IS  - 1744-5019 (Electronic)
IS  - 0360-5310 (Linking)
VI  - 35
IP  - 2
DP  - 2010 Apr
TI  - Reevaluating the dead donor rule.
PG  - 154-79
LID - 10.1093/jmp/jhq009 [doi]
AB  - The dead donor rule justifies current practice in organ procurement for
      transplantation and states that organ donors must be dead prior to donation. The 
      majority of organ donors are diagnosed as having suffered brain death and hence
      are declared dead by neurological criteria. However, a significant amount of
      unrest in both the philosophical and the medical literature has surfaced since
      this practice began forty years ago. I argue that, first, declaring death by
      neurological criteria is both unreliable and unjustified but further, the ethical
      principles which themselves justify the dead donor rule are better served by
      abandoning that rule and instead allowing individuals who have suffered severe
      and irreversible brain damage to become organ donors, even though they are not
      yet dead and even though the removal of their organs would be the proximal cause 
      of death.
FAU - Collins, Mike
AU  - Collins M
AD  - The Bioethics Program, Mount Sinai School of Medicine, One Gustave Levy Place,
      Box 1108, New York, NY 10029, USA. mike9943@gmail.com
LA  - eng
PT  - Journal Article
DEP - 20100225
PL  - United States
TA  - J Med Philos
JT  - The Journal of medicine and philosophy
JID - 7610512
SB  - IM
MH  - *Attitude to Death
MH  - Brain Damage, Chronic/diagnosis
MH  - *Brain Death/diagnosis/physiopathology
MH  - Coma/diagnosis
MH  - *Human Rights
MH  - Humans
MH  - Organ Transplantation/ethics
MH  - Reproducibility of Results
MH  - *Tissue Donors
MH  - Tissue and Organ Procurement/*ethics/legislation & jurisprudence
MH  - United States
EDAT- 2010/02/27 06:00
MHDA- 2010/06/17 06:00
CRDT- 2010/02/27 06:00
PHST- 2010/02/27 06:00 [entrez]
PHST- 2010/02/27 06:00 [pubmed]
PHST- 2010/06/17 06:00 [medline]
AID - jhq009 [pii]
AID - 10.1093/jmp/jhq009 [doi]
PST - ppublish
SO  - J Med Philos. 2010 Apr;35(2):154-79. doi: 10.1093/jmp/jhq009. Epub 2010 Feb 25.


PMID- 20185447
OWN - NLM
STAT- MEDLINE
DCOM- 20100602
LR  - 20100226
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 2
DP  - 2010 Mar
TI  - Perception of ethical climate and its relationship to nurses' demographic
      characteristics and job satisfaction.
PG  - 233-46
LID - 10.1177/0969733009352048 [doi]
AB  - In this study, we examined the perception of actual and ideal ethical climate
      type among 95 nurses working in the internal medicine wards of one central
      hospital in the state of Israel. We also examined whether nurses' demographic
      characteristics influence that perception and if a relationship between
      perceptions of an actual and an ideal ethical climate type influences nurses' job
      satisfaction. A questionnaire composed of three subquestionnaires was
      administered and the responses analyzed using multiple linear regressions,
      analysis of variance and Pearson's correlation coefficient. The results
      demonstrated that demographic characteristics (such as: gender, job tenure and
      level of education) partially influence the perception of an ideal ethical
      climate. Incongruence in perceptions of 'caring' and 'independence' climate types
      indicated a decline in nurses' job satisfaction, while perception of actual
      'caring' and 'service' climates positively influenced all aspects of job
      satisfaction. We recommend constructing training programs emphasizing the ethics 
      of nursing practice and also to help lead nurses to clarify an ethical framework 
      and guide nursing staff in dealing with ethical dilemmas.
FAU - Goldman, Anny
AU  - Goldman A
AD  - Tel Aviv University, Israel. goldman2455@walla.com
FAU - Tabak, Nili
AU  - Tabak N
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Adult
MH  - Ethical Theory
MH  - Ethics, Nursing
MH  - Female
MH  - Humans
MH  - Israel
MH  - *Job Satisfaction
MH  - Male
MH  - Middle Aged
MH  - Nursing Staff, Hospital/*ethics/organization & administration
MH  - *Organizational Culture
EDAT- 2010/02/27 06:00
MHDA- 2010/06/03 06:00
CRDT- 2010/02/27 06:00
PHST- 2010/02/27 06:00 [entrez]
PHST- 2010/02/27 06:00 [pubmed]
PHST- 2010/06/03 06:00 [medline]
AID - 17/2/233 [pii]
AID - 10.1177/0969733009352048 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 Mar;17(2):233-46. doi: 10.1177/0969733009352048.


PMID- 20185445
OWN - NLM
STAT- MEDLINE
DCOM- 20100602
LR  - 20220331
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 2
DP  - 2010 Mar
TI  - Moral stress, moral climate and moral sensitivity among psychiatric
      professionals.
PG  - 213-24
LID - 10.1177/0969733009351951 [doi]
AB  - The aim of the present study was to investigate the association between
      work-related moral stress, moral climate and moral sensitivity in mental health
      nursing. By means of the three scales Hospital Ethical Climate Survey, Moral
      Sensitivity Questionnaire and Work-Related Moral Stress, 49 participants'
      experiences were assessed. The results of linear regression analysis indicated
      that moral stress was determined to a degree by the work place's moral climate as
      well as by two aspects of the mental health staff's moral sensitivity. The
      nurses' experience of 'moral burden' or 'moral support' increased or decreased
      their experience of moral stress. Their work-related moral stress was determined 
      by the job-associated moral climate and two aspects of moral sensitivity. Our
      findings showed an association between three concepts: moral sensitivity, moral
      climate and moral stress. Despite being a small study, the findings seem relevant
      for future research leading to theory development and conceptual clarity. We
      suggest that more attention be given to methodological issues and developing
      designs that allow for comparative research in other disciplines, as well as
      in-depth knowledge of moral agency.
FAU - Lutzen, Kim
AU  - Lutzen K
AD  - Karolinska Institute, Stockholm, Sweden. kim.lutzen@ki.se
FAU - Blom, Tammy
AU  - Blom T
FAU - Ewalds-Kvist, Beatrice
AU  - Ewalds-Kvist B
FAU - Winch, Sarah
AU  - Winch S
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Adult
MH  - *Conflict, Psychological
MH  - Female
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - *Morals
MH  - Multivariate Analysis
MH  - Nursing Staff, Hospital/*ethics
MH  - *Organizational Culture
MH  - Psychiatric Nursing/*ethics
MH  - Psychological Tests
MH  - *Stress, Psychological
MH  - Sweden
EDAT- 2010/02/27 06:00
MHDA- 2010/06/03 06:00
CRDT- 2010/02/27 06:00
PHST- 2010/02/27 06:00 [entrez]
PHST- 2010/02/27 06:00 [pubmed]
PHST- 2010/06/03 06:00 [medline]
AID - 17/2/213 [pii]
AID - 10.1177/0969733009351951 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 Mar;17(2):213-24. doi: 10.1177/0969733009351951.


PMID- 20185444
OWN - NLM
STAT- MEDLINE
DCOM- 20100602
LR  - 20100226
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 2
DP  - 2010 Mar
TI  - Utilitarian and common-sense morality discussions in intercultural nursing
      practice.
PG  - 201-11
LID - 10.1177/0969733009355544 [doi]
AB  - Two areas of ethical conflict in intercultural nursing - who needs single rooms
      more, and how far should nurses go to comply with ethnic minority patients'
      wishes? - are discussed from a utilitarian and common-sense morality point of
      view. These theories may mirror nurses' way of thinking better than principled
      ethics, and both philosophies play a significant role in shaping nurses' decision
      making. Questions concerning room allocation, noisy behaviour, and demands that
      nurses are unprepared or unequipped for may be hard to cope with owing to
      physical restrictions and other patients' needs. Unsolvable problems may cause
      stress and a bad conscience as no solution is 'right' for all the patients
      concerned. Nurses experience a moral state of disequilibrium, which occurs when
      they feel responsible for the outcomes of their actions in situations that have
      no clear-cut solution.
FAU - Hanssen, Ingrid
AU  - Hanssen I
AD  - Lovisenberg Diaconal University College, 0456 Oslo, Norway. ingrid.hanssen@ldh.no
FAU - Alpers, Lise-Merete
AU  - Alpers LM
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Decision Making/*ethics
MH  - Female
MH  - Health Care Rationing/*ethics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Minority Groups
MH  - Morals
MH  - Norway
MH  - Nursing Staff, Hospital/*ethics
MH  - Patient Preference
MH  - Terminally Ill
MH  - Transcultural Nursing/*ethics
EDAT- 2010/02/27 06:00
MHDA- 2010/06/03 06:00
CRDT- 2010/02/27 06:00
PHST- 2010/02/27 06:00 [entrez]
PHST- 2010/02/27 06:00 [pubmed]
PHST- 2010/06/03 06:00 [medline]
AID - 17/2/201 [pii]
AID - 10.1177/0969733009355544 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 Mar;17(2):201-11. doi: 10.1177/0969733009355544.


PMID- 20185443
OWN - NLM
STAT- MEDLINE
DCOM- 20100602
LR  - 20191210
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 2
DP  - 2010 Mar
TI  - Encompassing multiple moral paradigms: a challenge for nursing educators.
PG  - 189-99
LID - 10.1177/0969733009355539 [doi]
AB  - Providing ethically competent care requires nurses to reflect not only on nursing
      ethics, but also on their own ethical traditions. New challenges for nurse
      educators over the last decade have been the increasing globalization of the
      nursing workforce and the internationalization of nursing education. In New
      Zealand, there has been a large increase in numbers of Chinese students, both
      international and immigrant, already acculturated with ethical and cultural
      values derived from Chinese Confucian moral traditions. Recently, several
      incidents involving Chinese nursing students in morally conflicting situations
      have led to one nursing faculty reflecting upon how moral philosophy is taught to
      non-European students and the support given to Chinese students in integrating
      the taught curriculum into real-life clinical practice settings. This article
      uses a case study involving a Chinese student to reflect on the challenges for
      both faculty members and students when encountering situations that present
      ethical dilemmas.
FAU - Caldwell, Elizabeth Shirin
AU  - Caldwell ES
AD  - Unitec Institute of Technology, Auckland 1142, New Zealand.
      scaldwell@unitec.ac.nz
FAU - Lu, Hongyan
AU  - Lu H
FAU - Harding, Thomas
AU  - Harding T
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - China/ethnology
MH  - Conflict, Psychological
MH  - Cultural Competency/*education
MH  - *Cultural Diversity
MH  - *Education, Nursing
MH  - Ethics, Nursing/*education
MH  - Female
MH  - Humans
MH  - Male
MH  - Morals
MH  - New Zealand
MH  - Nurse-Patient Relations/ethics
MH  - Organizational Case Studies
MH  - Religious Philosophies
EDAT- 2010/02/27 06:00
MHDA- 2010/06/03 06:00
CRDT- 2010/02/27 06:00
PHST- 2010/02/27 06:00 [entrez]
PHST- 2010/02/27 06:00 [pubmed]
PHST- 2010/06/03 06:00 [medline]
AID - 17/2/189 [pii]
AID - 10.1177/0969733009355539 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 Mar;17(2):189-99. doi: 10.1177/0969733009355539.


PMID- 20185442
OWN - NLM
STAT- MEDLINE
DCOM- 20100602
LR  - 20101208
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 2
DP  - 2010 Mar
TI  - Informed consent practices of Chinese nurse researchers.
PG  - 179-87
LID - 10.1177/0969733009355545 [doi]
AB  - Nursing research in China is at an early stage of development and little is known
      about the practices of Chinese nurse researchers. This interview study carried
      out at a university in central China explores the informed consent practices of
      Chinese nurse researchers and the cultural considerations of using a western
      technique. Nine semistructured interviews were conducted in English with
      assistance and simultaneous translation from a Chinese nurse with research
      experience. The interviews were analyzed by one western and two Chinese
      researchers and major themes were identified. All participants endorsed informed 
      consent as ethically required. Differences were noted between some of the
      informed consent practices typically recommended in the USA and those identified 
      in this study, such as: recruitment using local and government officials,
      recruiting directly from medical records without special permission, family
      consultation in consent and consent control, and not revealing randomization to
      intervention groups receiving different treatments.
FAU - Olsen, Douglas P
AU  - Olsen DP
AD  - Veterans Health Administration, Washington, DC 20420, USA. douglas.olsen@va.gov
FAU - Honghong Wang
AU  - Honghong Wang
FAU - Pang, Samantha
AU  - Pang S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
CIN - Nurs Ethics. 2010 Nov;17(6):791. PMID: 21097977
MH  - Adult
MH  - Attitude of Health Personnel/*ethnology
MH  - China
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Middle Aged
MH  - Nursing Research/*ethics
EDAT- 2010/02/27 06:00
MHDA- 2010/06/03 06:00
CRDT- 2010/02/27 06:00
PHST- 2010/02/27 06:00 [entrez]
PHST- 2010/02/27 06:00 [pubmed]
PHST- 2010/06/03 06:00 [medline]
AID - 17/2/179 [pii]
AID - 10.1177/0969733009355545 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 Mar;17(2):179-87. doi: 10.1177/0969733009355545.


PMID- 20185254
OWN - NLM
STAT- MEDLINE
DCOM- 20100928
LR  - 20220410
IS  - 1873-4111 (Electronic)
IS  - 0378-5122 (Linking)
VI  - 66
IP  - 1
DP  - 2010 May
TI  - Medical tourism: assessing the evidence on treatment abroad.
PG  - 27-32
LID - 10.1016/j.maturitas.2010.01.017 [doi]
AB  - The review focuses on one growing dimension of health care globalisation -
      medical tourism, whereby consumers elect to travel across borders or to overseas 
      destinations to receive their treatment. Such treatments include cosmetic and
      dental surgery; cardio, orthopaedic and bariatric surgery; IVF treatment; and
      organ and tissue transplantation. The review sought to identify the medical
      tourist literature for out-of-pocket payments, focusing wherever possible on
      evidence and experience pertaining to patients in mid-life and beyond. Despite
      increasing media interest and coverage hard empirical findings pertaining to
      out-of-pocket medical tourism are rare. Despite a number of countries offering
      relatively low cost treatments we know very little about many of the numbers and 
      key indicators on medical tourism. The narrative review traverses discussion on
      medical tourist markets, consumer choice, clinical outcomes, quality and safety, 
      and ethical and legal dimensions. The narrative review draws attention to gaps in
      research evidence and strengthens the call for more empirical research on the
      role, process and outcomes of medical tourism. In concluding it makes suggestion 
      for the content of such a strategy.
CI  - Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Lunt, Neil
AU  - Lunt N
AD  - The York Management School, University of York, Heslington, York, United Kingdom.
      nl517@york.ac.uk
FAU - Carrera, Percivil
AU  - Carrera P
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100224
PL  - Ireland
TA  - Maturitas
JT  - Maturitas
JID - 7807333
SB  - IM
MH  - Europe
MH  - *Health Care Sector/economics/ethics/legislation & jurisprudence
MH  - *Health Expenditures
MH  - Humans
MH  - *Medical Tourism/economics/ethics/legislation & jurisprudence
MH  - Treatment Outcome
RF  - 48
EDAT- 2010/02/27 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/02/27 06:00
PHST- 2010/01/18 00:00 [received]
PHST- 2010/01/26 00:00 [accepted]
PHST- 2010/02/27 06:00 [entrez]
PHST- 2010/02/27 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - S0378-5122(10)00044-7 [pii]
AID - 10.1016/j.maturitas.2010.01.017 [doi]
PST - ppublish
SO  - Maturitas. 2010 May;66(1):27-32. doi: 10.1016/j.maturitas.2010.01.017. Epub 2010 
      Feb 24.


PMID- 20185056
OWN - NLM
STAT- MEDLINE
DCOM- 20100601
LR  - 20211203
IS  - 1532-8449 (Electronic)
IS  - 0882-5963 (Linking)
VI  - 25
IP  - 2
DP  - 2010 Apr
TI  - Cultural sensitivity removes barriers to better care. A letter to the editor on
      article "parental preference or child well-being: an ethical dilemma".
PG  - 71
LID - 10.1016/j.pedn.2009.11.006 [doi]
FAU - Murayama, Shiho
AU  - Murayama S
LA  - eng
PT  - Case Reports
PT  - Letter
PT  - Comment
PL  - United States
TA  - J Pediatr Nurs
JT  - Journal of pediatric nursing
JID - 8607529
SB  - IM
CON - J Pediatr Nurs. 2010 Feb;25(1):58-63. PMID: 20117678
MH  - Asians
MH  - Caregivers/psychology
MH  - Child
MH  - Child Welfare
MH  - Cultural Characteristics
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Long-Term Care
MH  - Parent-Child Relations/*ethnology
MH  - Patient Care/*ethics/methods
MH  - Proteus Syndrome/diagnosis/ethnology/*therapy
EDAT- 2010/02/27 06:00
MHDA- 2010/06/02 06:00
CRDT- 2010/02/27 06:00
PHST- 2009/11/25 00:00 [received]
PHST- 2009/11/26 00:00 [accepted]
PHST- 2010/02/27 06:00 [entrez]
PHST- 2010/02/27 06:00 [pubmed]
PHST- 2010/06/02 06:00 [medline]
AID - S0882-5963(09)00339-X [pii]
AID - 10.1016/j.pedn.2009.11.006 [doi]
PST - ppublish
SO  - J Pediatr Nurs. 2010 Apr;25(2):71. doi: 10.1016/j.pedn.2009.11.006.


PMID- 20136916
OWN - NLM
STAT- MEDLINE
DCOM- 20100507
LR  - 20220311
IS  - 1529-8019 (Electronic)
IS  - 1396-0296 (Linking)
VI  - 23 Suppl 1
DP  - 2010 Jan-Feb
TI  - Correlation between BMI and PASI in patients affected by moderate to severe
      psoriasis undergoing biological therapy.
PG  - S14-9
LID - 10.1111/j.1529-8019.2009.01281.x [doi]
AB  - Obesity is common in psoriatic patients, and it has been shown to be important
      for many aspects of the condition. In particular, low-calorie diets can improve
      the symptoms and response to treatment in pustular psoriasis. The present study
      investigates the influence of body-weight alteration on the disease's clinical
      manifestations in moderate to severe psoriasis patients treated with biological
      drugs. Finally, the influence of a caloric restriction was assessed. This
      observational transversal study enrolled 33 patients attending our Severe
      Psoriasis Outpatient Clinic, who were treated with biological drugs. Body Mass
      Index (BMI) was used as a diagnostic indicator of being overweight and of
      obesity. Waist circumference was also measured. Body weight and Psoriasis Area
      Severity Index (PASI) index were measured at follow-up visits at 4 and 8 months. 
      Nonparametric test of Mann-Whitney was used to detect the differences between
      patient groups. Fisher's exact test was performed to evaluate the different
      results depending on the therapeutic changes of BMI. There was a strong
      prevalence of overweight-obese individuals in the group with a mean BMI of 30.59 
      +/- 6.94. Waist circumference was also above normal in the majority of the
      patients. Obese patients had a PASI index higher than the average of the whole
      group (25.03 +/- 12.43), with grade III obese patients having an average PASI of 
      44 +/- 3.37. At the first and second follow-ups, patients who put on weight did
      not achieve PASI 50; patients who had a stable weight presented variable response
      to treatment, while patients who decreased their weight achieved PASI 90 or PASI 
      75 even when not responding at the first. Further studies are needed to
      understand if the poor response observed in heavier patients is due to biological
      drugs pharmacokinetics or because therapy should be BMI based rather than
      administered in fixed doses, posing then an ethical consideration.
FAU - Bardazzi, F
AU  - Bardazzi F
AD  - Department of Internal Medicine, Oldness and Nephrologic Diseases, Division of
      Dermatology, University of Bologna, Bologna, Italy. federico.bardazzi@aosp.bo.it
FAU - Balestri, R
AU  - Balestri R
FAU - Baldi, E
AU  - Baldi E
FAU - Antonucci, A
AU  - Antonucci A
FAU - De Tommaso, S
AU  - De Tommaso S
FAU - Patrizi, A
AU  - Patrizi A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Dermatol Ther
JT  - Dermatologic therapy
JID - 9700070
RN  - 0 (Antibodies, Monoclonal)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antibodies, Monoclonal/therapeutic use
MH  - *Biological Therapy
MH  - *Body Mass Index
MH  - *Caloric Restriction
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity/classification/*complications
MH  - Psoriasis/complications/diet therapy/*therapy
MH  - *Severity of Illness Index
MH  - Waist Circumference
EDAT- 2010/02/27 06:00
MHDA- 2010/05/08 06:00
CRDT- 2010/02/09 06:00
PHST- 2010/02/09 06:00 [entrez]
PHST- 2010/02/27 06:00 [pubmed]
PHST- 2010/05/08 06:00 [medline]
AID - DTH1281 [pii]
AID - 10.1111/j.1529-8019.2009.01281.x [doi]
PST - ppublish
SO  - Dermatol Ther. 2010 Jan-Feb;23 Suppl 1:S14-9. doi:
      10.1111/j.1529-8019.2009.01281.x.


PMID- 20182700
OWN - NLM
STAT- MEDLINE
DCOM- 20100706
LR  - 20220321
IS  - 1433-0431 (Electronic)
IS  - 0085-4530 (Linking)
VI  - 39
IP  - 4
DP  - 2010 Apr
TI  - [Cell therapy in bone-healing disorders].
PG  - 449-62; quiz 463
LID - 10.1007/s00132-009-1583-7 [doi]
AB  - In addition to stabilizing osteosynthesis and autologous bone transplantation,
      so-called orthobiologics are playing an increasing role in the treatment of
      bone-healing disorders. Besides the application of different growth factors, new 
      data in the literature suggest that cell therapeutic agents promote local bone
      regeneration. Due to ethical and biological considerations, clinical application 
      of progenitor cells for the musculoskeletal system is limited to autologous
      postpartum stem cells. Here in particular, cell therapy with autologous
      progenitor cells in one surgical session has delivered first promising results.
      Based on a review of the literature and on our own experience with 75 patients,
      this article reviews the rationale and characteristics of the clinical
      application of cell therapy for the treatment of bony substance defects. Most
      clinical trials report successful bone regeneration after the application of
      mixed cell populations from bone marrow.
FAU - Jager, M
AU  - Jager M
AD  - Orthopadische Klinik, Universitatsklinikum, Heinrich-Heine-Universitat
      Dusseldorf, Moorenstrasse 5, 40225, Dusseldorf, Deutschland.
      Jaeger@med.uni-duesseldorf.de
FAU - Hernigou, P
AU  - Hernigou P
FAU - Zilkens, C
AU  - Zilkens C
FAU - Herten, M
AU  - Herten M
FAU - Fischer, J
AU  - Fischer J
FAU - Krauspe, R
AU  - Krauspe R
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Zelltherapie bei Knochenheilungsstorungen.
PL  - Germany
TA  - Orthopade
JT  - Der Orthopade
JID - 0331266
RN  - 91D9GV0Z28 (Durapatite)
SB  - IM
MH  - Adolescent
MH  - Bone Cysts/surgery
MH  - Bone Neoplasms/*surgery
MH  - Bone Regeneration/*physiology
MH  - Bone Transplantation
MH  - Cell Differentiation/physiology
MH  - Child
MH  - Chondroma/surgery
MH  - Combined Modality Therapy
MH  - Durapatite
MH  - Fracture Healing/*physiology
MH  - Humans
MH  - Mesenchymal Stem Cell Transplantation/*methods
MH  - Osteoblasts/cytology
MH  - Tissue and Organ Harvesting/methods
RF  - 80
EDAT- 2010/02/26 06:00
MHDA- 2010/07/07 06:00
CRDT- 2010/02/26 06:00
PHST- 2010/02/26 06:00 [entrez]
PHST- 2010/02/26 06:00 [pubmed]
PHST- 2010/07/07 06:00 [medline]
AID - 10.1007/s00132-009-1583-7 [doi]
PST - ppublish
SO  - Orthopade. 2010 Apr;39(4):449-62; quiz 463. doi: 10.1007/s00132-009-1583-7.


PMID- 20182490
OWN - NLM
STAT- MEDLINE
DCOM- 20100412
LR  - 20211020
IS  - 1476-4687 (Electronic)
IS  - 0028-0836 (Linking)
VI  - 463
IP  - 7284
DP  - 2010 Feb 25
TI  - Rigid animal-rights views not useful to ethics debate.
PG  - 1018
LID - 10.1038/4631018b [doi]
FAU - Campbell, Rob
AU  - Campbell R
LA  - eng
PT  - Comment
PT  - Letter
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
SB  - IM
CON - Nature. 2010 Jan 21;463(7279):293. PMID: 20090728
MH  - Animal Experimentation/*ethics
MH  - *Animal Rights
MH  - Ethics Committees/*organization & administration
MH  - *Universities
EDAT- 2010/02/26 06:00
MHDA- 2010/04/13 06:00
CRDT- 2010/02/26 06:00
PHST- 2010/02/26 06:00 [entrez]
PHST- 2010/02/26 06:00 [pubmed]
PHST- 2010/04/13 06:00 [medline]
AID - 4631018b [pii]
AID - 10.1038/4631018b [doi]
PST - ppublish
SO  - Nature. 2010 Feb 25;463(7284):1018. doi: 10.1038/4631018b.


PMID- 20182131
OWN - NLM
STAT- MEDLINE
DCOM- 20100322
LR  - 20211020
IS  - 1938-808X (Electronic)
IS  - 1040-2446 (Linking)
VI  - 85
IP  - 3
DP  - 2010 Mar
TI  - Evaluating the effects that existing instruction on responsible conduct of
      research has on ethical decision making.
PG  - 519-26
LID - 10.1097/ACM.0b013e3181cd1cc5 [doi]
AB  - PURPOSE: To examine the effects that existing courses on the responsible conduct 
      of research (RCR) have on ethical decision making by assessing the ethicality of 
      decisions made in response to ethical problems and the underlying processes
      involved in ethical decision making. These processes included how an individual
      thinks through ethical problems (i.e., meta-cognitive reasoning strategies) and
      the emphasis placed on social dimensions of ethical problems (i.e.,
      social-behavioral responses). METHOD: In 2005-2007, recruitment announcements
      were made, stating that a nationwide, online study was being conducted to examine
      the impact of RCR instruction on the ethical decision making of scientists.
      Recruitment yielded contacts with over 200 RCR faculty at 21 research
      universities and medical schools; 40 (20%) RCR instructors enrolled their courses
      in the current study. From those courses, 173 participants completed an ethical
      decision-making measure. RESULTS: A mixed pattern of effects emerged. The
      ethicality of decisions did not improve as a result of RCR instruction and even
      decreased for decisions pertaining to business aspects of research, such as
      contract bidding. Course participants improved on some meta-cognitive reasoning
      strategies, such as awareness of the situation and consideration of personal
      motivations, but declined for seeking help and considering others' perspectives. 
      Participants also increased their endorsement of detrimental social-behavioral
      responses, such as deception, retaliation, and avoidance of personal
      responsibility. CONCLUSIONS: These findings indicated that RCR instruction may
      not be as effective as intended and, in fact, may even be harmful. Harmful
      effects might result if instruction leads students to overstress avoidance of
      ethical problems, be overconfident in their ability to handle ethical problems,
      or overemphasize their ethical nature. Future research must examine these and
      other possible obstacles to effective RCR instruction.
FAU - Antes, Alison L
AU  - Antes AL
AD  - Department of Psychology, Center for Applied Social Research, University of
      Oklahoma, Norman, Oklahoma 73072, USA. alisonantes@ou.edu
FAU - Wang, Xiaoqian
AU  - Wang X
FAU - Mumford, Michael D
AU  - Mumford MD
FAU - Brown, Ryan P
AU  - Brown RP
FAU - Connelly, Shane
AU  - Connelly S
FAU - Devenport, Lynn D
AU  - Devenport LD
LA  - eng
GR  - R01 NS049535/NS/NINDS NIH HHS/United States
GR  - 5R01-NS049535-02/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Acad Med
JT  - Academic medicine : journal of the Association of American Medical Colleges
JID - 8904605
SB  - IM
MH  - Biomedical Research/*education/*ethics
MH  - Decision Making/*ethics
PMC - PMC4578657
MID - NIHMS717604
EDAT- 2010/02/26 06:00
MHDA- 2010/03/23 06:00
CRDT- 2010/02/26 06:00
PHST- 2010/02/26 06:00 [entrez]
PHST- 2010/02/26 06:00 [pubmed]
PHST- 2010/03/23 06:00 [medline]
AID - 10.1097/ACM.0b013e3181cd1cc5 [doi]
AID - 00001888-201003000-00032 [pii]
PST - ppublish
SO  - Acad Med. 2010 Mar;85(3):519-26. doi: 10.1097/ACM.0b013e3181cd1cc5.


PMID- 20182022
OWN - NLM
STAT- MEDLINE
DCOM- 20100908
LR  - 20220311
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Linking)
VI  - 20
IP  - 3
DP  - 2010
TI  - Antihypertensive treatments, cognitive decline, and dementia.
PG  - 903-14
LID - 10.3233/JAD-2010-091552 [doi]
AB  - Chronic hypertension is associated with an increased risk of both vascular
      dementia and Alzheimer's disease (AD). In this context, the role of
      anti-hypertensive therapy for the prevention and delay of cognitive decline and
      dementia is of central importance. Most longitudinal studies have shown a
      significant inverse association between anti-hypertensive therapies and dementia 
      incidence and for some of these, particularly in AD. Seven randomized, double
      blind placebo-controlled trials have evaluated the benefit of antihypertensive
      treatments on cognition. Three of them found positive results in term of
      prevention of dementia (SYST-EUR) or cognitive decline (PROGRESS, HOPE). Others
      disclosed non-significant results (MRC, SHEP, SCOPE, HYVET-COG). This discrepancy
      emphasizes the difficulty to perform such trials: the follow-up has to be long
      enough to disclose a benefit, a large number of patients is needed for these
      studies, and because of ethical reasons some anti-hypertensive treatments are
      often prescribed in the placebo group. Results of the two more recent
      meta-analyses are inconsistent, possibly due to methodological issues.
      Antihypertensive treatments could be beneficial to cognitive function by lowering
      blood pressure and/or by specific neuroprotective effect. Three main
      antihypertensive subclasses have been associated with a beneficial effect on
      cognitive function beyond blood pressure reduction (calcium channel blockers,
      angiotensin converting enzyme inhibitor, angiotensin-AT1-receptor-blockers).
      Further long-term randomized trials, designed especially to assess a link between
      antihypertensive therapy and cognitive decline or dementia are therefore needed
      with cognition as the primary outcome. A low blood pressure threshold that could 
      be deleterious for cognitive function should also be determined.
FAU - Duron, Emmanuelle
AU  - Duron E
AD  - Department of Geriatrics, University Paris- Descartes, Broca Hospital, AP-HP,
      France. emmanuelle.duron@brc.aphp.fr
FAU - Hanon, Olivier
AU  - Hanon O
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
RN  - 0 (Antihypertensive Agents)
SB  - IM
MH  - Antihypertensive Agents/*therapeutic use
MH  - Cognition Disorders/*drug therapy
MH  - Dementia/*drug therapy
MH  - Humans
MH  - Hypertension/drug therapy
MH  - Longitudinal Studies
MH  - Randomized Controlled Trials as Topic
RF  - 71
EDAT- 2010/02/26 06:00
MHDA- 2010/09/09 06:00
CRDT- 2010/02/26 06:00
PHST- 2010/02/26 06:00 [entrez]
PHST- 2010/02/26 06:00 [pubmed]
PHST- 2010/09/09 06:00 [medline]
AID - J2X910511738305H [pii]
AID - 10.3233/JAD-2010-091552 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2010;20(3):903-14. doi: 10.3233/JAD-2010-091552.


PMID- 20181644
OWN - NLM
STAT- MEDLINE
DCOM- 20100616
LR  - 20100312
IS  - 1744-5019 (Electronic)
IS  - 0360-5310 (Linking)
VI  - 35
IP  - 2
DP  - 2010 Apr
TI  - From brute luck to option luck? On genetics, justice, and moral responsibility in
      reproduction.
PG  - 101-29
LID - 10.1093/jmp/jhq007 [doi]
AB  - The structure of our ethical experience depends, crucially, on a fundamental
      distinction between what we are responsible for doing or deciding and what is
      given to us. As such, the boundary between chance and choice is the spine of our 
      conventional morality, and any serious shift in that boundary is thoroughly
      dislocating. Against this background, I analyze the way in which techniques of
      prenatal genetic diagnosis (PGD) pose such a fundamental challenge to our
      conventional ideas of justice and moral responsibility. After a short description
      of the situation, I first examine the influential luck egalitarian theory of
      justice, which is based on the distinction between choice and luck or, more
      specifically, between option luck and brute luck, and the way in which it would
      approach PGD (section II), followed by an analysis of the conceptual
      incoherencies (in section III) and moral problems (in section IV) that come with 
      such an approach. Put shortly, the case of PGD shows that the luck egalitarian
      approach fails to express equal respect for the individual choices of people. The
      paradox of the matter is that by overemphasizing the fact of choice as such,
      without regard for the social framework in which they are being made, or for the 
      fundamental and existential nature of particular choices-like choosing to have
      children and not to undergo PGD or not to abort a handicapped fetus-such choices 
      actually become impossible.
FAU - Denier, Yvonne
AU  - Denier Y
AD  - Center for Biomedical Ethics and Law, Catholic University of Leuven,
      Kapucijnenvoer 35, Block D, Box 7001, 3000 Leuven, Belgium.
      yvonne.denier@med.kuleuven.be
LA  - eng
PT  - Journal Article
DEP - 20100224
PL  - United States
TA  - J Med Philos
JT  - The Journal of medicine and philosophy
JID - 7610512
SB  - IM
MH  - Choice Behavior
MH  - Ethical Analysis
MH  - Genetic Diseases, Inborn
MH  - Genetic Testing/*ethics
MH  - Humans
MH  - *Moral Obligations
MH  - Prenatal Diagnosis/*ethics
MH  - *Social Justice
MH  - Social Values
MH  - Wrongful Life/*ethics
EDAT- 2010/02/26 06:00
MHDA- 2010/06/17 06:00
CRDT- 2010/02/26 06:00
PHST- 2010/02/26 06:00 [entrez]
PHST- 2010/02/26 06:00 [pubmed]
PHST- 2010/06/17 06:00 [medline]
AID - jhq007 [pii]
AID - 10.1093/jmp/jhq007 [doi]
PST - ppublish
SO  - J Med Philos. 2010 Apr;35(2):101-29. doi: 10.1093/jmp/jhq007. Epub 2010 Feb 24.


PMID- 20180290
OWN - NLM
STAT- MEDLINE
DCOM- 20100409
LR  - 20100809
IS  - 0031-7179 (Print)
IS  - 0031-7179 (Linking)
VI  - 73
IP  - 1
DP  - 2010 Winter
TI  - The ethics of cosmetic enhancement.
PG  - 18-23
FAU - Raphael, Anna
AU  - Raphael A
AD  - Montefiore Medical Center, Bronx, USA. araphael@medalum.pitt.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pharos Alpha Omega Alpha Honor Med Soc
JT  - The Pharos of Alpha Omega Alpha-Honor Medical Society. Alpha Omega Alpha
JID - 19610620R
SB  - IM
CIN - Pharos Alpha Omega Alpha Honor Med Soc. 2010 Summer;73(3):51. PMID: 20690558
MH  - Beauty
MH  - Biomedical Enhancement/*ethics/standards
MH  - *Body Image
MH  - *Ethics, Medical
MH  - Europe
MH  - Humans
MH  - *Public Opinion
MH  - Reconstructive Surgical Procedures/*ethics/statistics & numerical data
MH  - Social Desirability
MH  - Social Justice
MH  - Social Perception
MH  - Social Values
MH  - Surgery, Plastic/*ethics/statistics & numerical data
MH  - United States
EDAT- 2010/02/25 06:00
MHDA- 2010/04/10 06:00
CRDT- 2010/02/25 06:00
PHST- 2010/02/25 06:00 [entrez]
PHST- 2010/02/25 06:00 [pubmed]
PHST- 2010/04/10 06:00 [medline]
PST - ppublish
SO  - Pharos Alpha Omega Alpha Honor Med Soc. 2010 Winter;73(1):18-23.


PMID- 20179939
OWN - NLM
STAT- MEDLINE
DCOM- 20100921
LR  - 20220317
IS  - 1432-1084 (Electronic)
IS  - 0938-7994 (Linking)
VI  - 20
IP  - 7
DP  - 2010 Jul
TI  - Predictive value of diffusion-weighted magnetic resonance imaging during
      chemoradiotherapy for head and neck squamous cell carcinoma.
PG  - 1703-14
LID - 10.1007/s00330-010-1734-6 [doi]
AB  - OBJECTIVE: To evaluate diffusion-weighted (DWI) magnetic resonance imaging (MRI) 
      for treatment prediction during chemoradiotherapy (CRT) of head and neck squamous
      cell carcinoma (HNC). METHODS: Thirty patients with HNC underwent echo-planar DWI
      and anatomical MRI before and 2 and 4 weeks into CRT. Patient follow-up lasted 2 
      years post-CRT. Tumour ADC (DeltaADC) and volume changes (DeltaV) between
      baseline, and 2 and 4 weeks' follow-up were compared for lesions with recurrence 
      versus complete remission (CR) using a Mann-Whitney U test. The predictive value 
      of the DeltaADC and DeltaV for locoregional control (LRC) was examined with the
      Kaplan-Meier method. The study was approved by the local ethics committee. All
      patients gave written informed consent. RESULTS: The DeltaADC in primary tumours 
      and nodal metastases, 2 and 4 weeks after the start of CRT, was significantly
      lower in lesions with post-CRT recurrence than in lesions with CR (DeltaADC(2
      weeks) and DeltaADC(4 weeks) for primary tumours, relative to nodal metastases: p
      < 0.0001). The DeltaV only showed a significant difference for primary tumours at
      2 weeks (DeltaV(2 weeks): p = 0.03). The DeltaADC correlated significantly with
      2-year LRC (p < 0.001); the DeltaV did not (p > 0.05). CONCLUSION: DWI during CRT
      for HNC allows more accurate response prediction than anatomical imaging,
      correlating significantly with 2-year LRC.
FAU - Vandecaveye, Vincent
AU  - Vandecaveye V
AD  - Department of Radiology, University Hospitals Leuven, Leuven, Belgium.
      Vincent.Vandecaveye@uzleuven.be
FAU - Dirix, Piet
AU  - Dirix P
FAU - De Keyzer, Frederik
AU  - De Keyzer F
FAU - de Beeck, Katya Op
AU  - de Beeck KO
FAU - Vander Poorten, Vincent
AU  - Vander Poorten V
FAU - Roebben, I
AU  - Roebben I
FAU - Nuyts, Sandra
AU  - Nuyts S
FAU - Hermans, Robert
AU  - Hermans R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100224
PL  - Germany
TA  - Eur Radiol
JT  - European radiology
JID - 9114774
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/*drug therapy/*radiotherapy
MH  - *Diffusion Magnetic Resonance Imaging
MH  - Female
MH  - Head and Neck Neoplasms/*drug therapy/*radiotherapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Treatment Outcome
MH  - Tumor Burden
EDAT- 2010/02/25 06:00
MHDA- 2010/09/23 06:00
CRDT- 2010/02/25 06:00
PHST- 2009/09/02 00:00 [received]
PHST- 2009/12/17 00:00 [accepted]
PHST- 2009/11/25 00:00 [revised]
PHST- 2010/02/25 06:00 [entrez]
PHST- 2010/02/25 06:00 [pubmed]
PHST- 2010/09/23 06:00 [medline]
AID - 10.1007/s00330-010-1734-6 [doi]
PST - ppublish
SO  - Eur Radiol. 2010 Jul;20(7):1703-14. doi: 10.1007/s00330-010-1734-6. Epub 2010 Feb
      24.


PMID- 20179362
OWN - NLM
STAT- MEDLINE
DCOM- 20100504
LR  - 20220409
IS  - 1349-9092 (Electronic)
IS  - 0917-5040 (Linking)
VI  - 20 Suppl 2
DP  - 2010
TI  - Incidental findings of brain magnetic resonance imaging study in a pediatric
      cohort in Japan and recommendation for a model management protocol.
PG  - S498-504
AB  - BACKGROUND: The increasing use of magnetic resonance imaging (MRI) in brain
      researches has led to growing concern over incidental findings (IFs). To
      establish a practical management protocol for IFs, it is useful to know the
      actual prevalence and problems of IF management. In the present study, we report 
      the prevalence proportion and some handling problems of IFs in healthy Japanese
      children, and suggest a management protocol from ethical and practical
      standpoints. METHODS: Between 2006 and 2008, 120 healthy children aged 5-8 years 
      participated in a structural MRI study conducted in a pediatric cohort in Japan. 
      All MRI images were reviewed by a pediatric neurologist, and detected IFs were
      classified into 4 categories. RESULTS: IFs of all categories were detected in 40 
      of the 110 participants (36.4%) for whom T2-weighted or 3D-T1-weighted images
      were available. Findings of sinusitis and/or otitis media were most frequent
      (26.4%). Excluding these findings, the prevalence of IFs was still 10.9% (12
      findings): 9 findings were categorized as "no referral" (8.2%), 2 as "routine
      referral" (1.8%), 1 as "urgent referral" (0.9%), and 0 as "immediate referral"
      (0.0%). In "routine referral" category, only one participant was referred for
      further examinations. CONCLUSIONS: Although the prevalence of IFs was high, the
      proportion of those requiring further examination was low. This result revealed a
      fairly high false-positive rate and suggested that evaluating equivocal findings 
      was the most difficult part of IF management. A management protocol needs to
      include a process to properly assess the clinical importance of findings.
FAU - Seki, Ayumi
AU  - Seki A
AD  - Research Institute of Science and Technology for Society, Japan Science and
      Technology Agency, Tokyo, Japan.
FAU - Uchiyama, Hitoshi
AU  - Uchiyama H
FAU - Fukushi, Tamami
AU  - Fukushi T
FAU - Sakura, Osamu
AU  - Sakura O
FAU - Tatsuya, Koeda
AU  - Tatsuya K
CN  - Japan Children's Study Group
LA  - eng
PT  - Journal Article
DEP - 20100223
PL  - Japan
TA  - J Epidemiol
JT  - Journal of epidemiology
JID - 9607688
SB  - IM
MH  - Brain/*pathology
MH  - Child
MH  - Child, Preschool
MH  - Clinical Protocols/*standards
MH  - Cohort Studies
MH  - False Positive Reactions
MH  - Female
MH  - Humans
MH  - Imaging, Three-Dimensional
MH  - *Incidental Findings
MH  - Japan
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Referral and Consultation/classification/statistics & numerical data
PMC - PMC3920402
EDAT- 2010/02/25 06:00
MHDA- 2010/05/05 06:00
CRDT- 2010/02/25 06:00
PHST- 2010/02/25 06:00 [entrez]
PHST- 2010/02/25 06:00 [pubmed]
PHST- 2010/05/05 06:00 [medline]
AID - JST.JSTAGE/jea/JE20090196 [pii]
AID - 10.2188/jea.je20090196 [doi]
PST - ppublish
SO  - J Epidemiol. 2010;20 Suppl 2:S498-504. doi: 10.2188/jea.je20090196. Epub 2010 Feb
      23.


PMID- 20179136
OWN - NLM
STAT- MEDLINE
DCOM- 20100824
LR  - 20100518
IS  - 1569-9285 (Electronic)
IS  - 1569-9285 (Linking)
VI  - 10
IP  - 6
DP  - 2010 Jun
TI  - Cervical incision thoracic endoscopic surgery: a minimally invasive endoscopic
      approach in thoracic surgery.
PG  - 967-70
LID - 10.1510/icvts.2009.228262 [doi]
AB  - Cervical incision thoracic surgery has recently been described. Currently, there 
      is a move to increase the role of flexible endoscopy in surgery. The use of a
      flexible endoscope through a natural orifice into the thoracic cavity still
      remains ethically doubtful. The authors present a surgical experimental study
      using a flexible endoscope through a cervical incision for the exploration of
      both the mediastinum and the thoracic cavity in a cadaver. An experimental work
      on 10 refrigerated and non-embalmed cadavers was initiated. We used a unique
      device - a standard double-channel flexible video gastroscope. Through a small
      cervical incision, we performed simultaneous exploration of the mediastinum and
      both pleural cavities. Identification and biopsies of mediastinal lymph nodes at 
      levels 2R, 4R, 7 and 4L were easy to perform in all subjects. In eight cadavers, 
      we performed an assessment of bilateral pleural cavities and multiple pleural
      biopsies as well as bilateral thoracic sympathectomy. A chest tube was placed in 
      the thoracic cavity at the end of all pleural procedures. The potential
      advantages of this approach are simultaneous exploration of the mediastinum and
      pleura and the performance of several thoracic interventions through a small
      cervical incision. The flexible endoscope could become a surgical tool for
      thoracic surgery.
FAU - Assouad, Jalal
AU  - Assouad J
AD  - Department of Thoracic Surgery, Tenon Hospital, 4 rue de Chine, 75020 Paris,
      France. jalal.assouad@tnn.aphp.fr
FAU - Steltzlen, Camille
AU  - Steltzlen C
FAU - Masmoudi, Hichem
AU  - Masmoudi H
FAU - Vignes, Stephane
AU  - Vignes S
FAU - Gounant, Valerie
AU  - Gounant V
FAU - Delmas, Vincent
AU  - Delmas V
FAU - Grunenwald, Dominique
AU  - Grunenwald D
LA  - eng
PT  - Journal Article
DEP - 20100223
PL  - England
TA  - Interact Cardiovasc Thorac Surg
JT  - Interactive cardiovascular and thoracic surgery
JID - 101158399
SB  - IM
MH  - Aged, 80 and over
MH  - Biopsy
MH  - Cadaver
MH  - Chest Tubes
MH  - Equipment Design
MH  - Gastroscopes
MH  - Humans
MH  - Intubation, Intratracheal
MH  - Lymph Nodes/*surgery
MH  - Mediastinum/*surgery
MH  - Pleura/innervation/*surgery
MH  - Sympathectomy
MH  - *Thoracic Surgery, Video-Assisted/instrumentation
MH  - Thoracoscopes
EDAT- 2010/02/25 06:00
MHDA- 2010/08/25 06:00
CRDT- 2010/02/25 06:00
PHST- 2010/02/25 06:00 [entrez]
PHST- 2010/02/25 06:00 [pubmed]
PHST- 2010/08/25 06:00 [medline]
AID - icvts.2009.228262 [pii]
AID - 10.1510/icvts.2009.228262 [doi]
PST - ppublish
SO  - Interact Cardiovasc Thorac Surg. 2010 Jun;10(6):967-70. doi:
      10.1510/icvts.2009.228262. Epub 2010 Feb 23.


PMID- 20178881
OWN - NLM
STAT- MEDLINE
DCOM- 20100716
LR  - 20161229
IS  - 1879-3479 (Electronic)
IS  - 0020-7292 (Linking)
VI  - 109
IP  - 2
DP  - 2010 May
TI  - Special commentary on the issue of reinfibulation.
PG  - 97-9
LID - 10.1016/j.ijgo.2010.01.004 [doi]
AB  - Policy on reinfibulation exposes the interface between individual or micro-ethics
      and population-wide or macro-ethics. If, following childbirth, an infibulated
      woman requests reinfibulation, a gynecologist may respectfully advise her of its 
      negative implications, but would not act in breach of ethical or usually legal
      requirements in undertaking the procedure. However, as a matter of health policy 
      and professional responsibility, physicians should refuse to initiate
      infibulation, and advise their patients and communities that the procedure is
      harmful, not required by religious or other ordinance, and frequently if not
      always unlawful. Reinfibulation is not genital cutting (or "mutilation") in
      itself, but when undertaken by a physician may appear to condone infibulation.
      This is contrary to medical professional ethics, which condemn medicalization of 
      infibulation and generally of reinfibulation, even as a harm-reduction strategy
      to spare women the risks of injury and infection from unskilled interventions.
CI  - Copyright 2010 International Federation of Gynecology and Obstetrics. Published
      by Elsevier Ireland Ltd. All rights reserved.
FAU - Cook, Rebecca J
AU  - Cook RJ
AD  - Faculty of Law, Faculty of Medicine and Joint Centre for Bioethics, University of
      Toronto, Toronto, Canada M5S 2C5.
FAU - Dickens, Bernard M
AU  - Dickens BM
LA  - eng
PT  - Journal Article
DEP - 20100223
PL  - United States
TA  - Int J Gynaecol Obstet
JT  - International journal of gynaecology and obstetrics: the official organ of the
      International Federation of Gynaecology and Obstetrics
JID - 0210174
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - *Circumcision, Female
MH  - Ethics, Medical
MH  - Female
MH  - Humans
MH  - Informed Consent
MH  - Physician-Patient Relations
MH  - Religion and Medicine
MH  - Social Values
MH  - Women's Health
MH  - Young Adult
EDAT- 2010/02/25 06:00
MHDA- 2010/07/17 06:00
CRDT- 2010/02/25 06:00
PHST- 2010/02/25 06:00 [entrez]
PHST- 2010/02/25 06:00 [pubmed]
PHST- 2010/07/17 06:00 [medline]
AID - S0020-7292(10)00045-7 [pii]
AID - 10.1016/j.ijgo.2010.01.004 [doi]
PST - ppublish
SO  - Int J Gynaecol Obstet. 2010 May;109(2):97-9. doi: 10.1016/j.ijgo.2010.01.004.
      Epub 2010 Feb 23.


PMID- 20178684
OWN - NLM
STAT- MEDLINE
DCOM- 20110218
LR  - 20161021
IS  - 0144-6665 (Print)
IS  - 0144-6665 (Linking)
VI  - 49
IP  - Pt 4
DP  - 2010 Dec
TI  - Contemporary discursive psychology: issues, prospects, and Corcoran's awkward
      ontology.
PG  - 657-78
LID - 10.1348/014466610X486158 [doi]
AB  - This paper is both an overview of the status of contemporary discursive
      psychology and a response to Corcoran's critical article. The first part of the
      paper reports on the main traditions that make up contemporary discursive
      psychology and how they relate to one another. Then it responds to Corcoran's
      claims that much of contemporary discursive psychology: (a) is over concerned
      with epistemic issues at the expense of ontological issues; (b) is too concerned 
      with data purity while failing reflexively to address its own practices; (c)
      fails to address ethical, applied, and political issues in the way that a
      reformed 'ontological' discursive psychology would be able to; (d) fails to
      provide an adequate and rich account of relationality (of the kind offered by
      thinkers such as Bakhtin, Shotter, and Chouliaraki). The limitations of each
      point are addressed in turn, highlighting errors and confusions. The broadly
      epistemic focus is appropriate for the subject matter of discursive psychology;
      discursive psychology is less concerned with data purity than with pursuing the
      radical and empirically progressive possibilities in studying records of people
      living their lives in everyday and institutional settings (a surprising oversight
      in a discipline focused on the actions of human beings) and it has a reflexive
      tradition going back two decades; it has a strong and distinctive focus on
      ethical, applied, and political issues; it has an account of relationality that
      is grounded in conversational materials. A single example from interaction on a
      child protection helpline is analysed to illustrate the way relationality,
      knowledge, and intersubjectivity have been made analytically tractable in
      contemporary discursive research.
FAU - Potter, Jonathan
AU  - Potter J
AD  - Discourse and Rhetoric Group, Department of Social Sciences, Loughborough
      University, UK. j.a.potter@lboro.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20100222
PL  - England
TA  - Br J Soc Psychol
JT  - The British journal of social psychology
JID - 8105534
SB  - IM
CIN - Br J Soc Psychol. 2010 Dec;49(Pt 4):679-84; discussion 691-701. PMID: 21260960
CIN - Br J Soc Psychol. 2010 Dec;49(Pt 4):685-90; discussion 691-701. PMID: 21260961
MH  - Behavioral Research/ethics/*methods
MH  - Child
MH  - Child Abuse/prevention & control
MH  - Ethics, Research
MH  - Hotlines
MH  - Humans
MH  - Interpersonal Relations
MH  - *Narration
MH  - Politics
MH  - Psychology, Social/*methods
EDAT- 2010/02/25 06:00
MHDA- 2011/02/22 06:00
CRDT- 2010/02/25 06:00
PHST- 2010/02/25 06:00 [entrez]
PHST- 2010/02/25 06:00 [pubmed]
PHST- 2011/02/22 06:00 [medline]
AID - bjsp1119 [pii]
AID - 10.1348/014466610X486158 [doi]
PST - ppublish
SO  - Br J Soc Psychol. 2010 Dec;49(Pt 4):657-78. doi: 10.1348/014466610X486158. Epub
      2010 Feb 22.


PMID- 20178561
OWN - NLM
STAT- MEDLINE
DCOM- 20100510
LR  - 20220330
IS  - 1741-7015 (Electronic)
IS  - 1741-7015 (Linking)
VI  - 8
DP  - 2010 Feb 23
TI  - Frequency and circumstances of placebo use in clinical practice--a systematic
      review of empirical studies.
PG  - 15
LID - 10.1186/1741-7015-8-15 [doi]
AB  - BACKGROUND: The use of placebo interventions outside clinical trials is
      ethically, professionally and legally controversial. Little is known about the
      frequency and circumstances of placebo use in clinical practice. Our aim was to
      summarize the available empirical studies addressing these issues. METHODS: We
      searched PubMed and EMBASE from inception to July 2009 in order to identify
      cross-sectional surveys, qualitative or longitudinal studies among health care
      professionals, students or patients which investigated at least one of the
      following issues--frequency of placebo use or attitudes to, or motivations for,
      the use of placebo interventions. At least two reviewers extracted information on
      the study methods, participants and findings. Descriptive summaries were prepared
      in an iterative process by at least two reviewers per study. RESULTS: Twenty-two 
      studies from 12 different countries met the inclusion criteria. Most studies had 
      relevant shortcomings. The proportion of respondents reporting that they had
      applied 'pure' placebos (for example, saline injection) during their professional
      life varied between 17% and 80% among physicians and between 51% and 100% among
      nurses, but it seems that the actual frequency of such use seems to be rare. The 
      use of 'impure' or 'active' placebos (for example, antibiotics for viral
      infections) is likely to be much more frequent. However, it is impossible to make
      a reliable estimation because there is no agreement of what an impure placebo
      might be. Studies using qualitative methods or asking participants to judge case 
      examples suggest that motivations and attitudes towards placebo use are complex
      and health care providers are often faced with a dilemma. CONCLUSIONS: Although
      the available evidence is incomplete and confusing at times there can be little
      doubt that the prevalence of placebo use outside of clinical trials is not
      negligible and that views and attitudes on placebos use differ considerably among
      individuals, both health care professionals and patients. Further research is
      needed to clarify these issues.
FAU - Fassler, Margrit
AU  - Fassler M
AD  - Institute of Biomedical Ethics, University of Zurich, 8008 Zurich, Switzerland.
      faessler@ethik.uzh.ch
FAU - Meissner, Karin
AU  - Meissner K
FAU - Schneider, Antonius
AU  - Schneider A
FAU - Linde, Klaus
AU  - Linde K
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20100223
PL  - England
TA  - BMC Med
JT  - BMC medicine
JID - 101190723
RN  - 0 (Placebos)
SB  - IM
MH  - Bioethics
MH  - Clinical Trials as Topic/ethics/methods
MH  - Empirical Research
MH  - *Health Knowledge, Attitudes, Practice
MH  - Health Personnel/psychology/statistics & numerical data
MH  - Humans
MH  - Placebos/*administration & dosage
MH  - Surveys and Questionnaires
RF  - 40
PMC - PMC2837612
EDAT- 2010/02/25 06:00
MHDA- 2010/05/11 06:00
CRDT- 2010/02/25 06:00
PHST- 2010/01/27 00:00 [received]
PHST- 2010/02/23 00:00 [accepted]
PHST- 2010/02/25 06:00 [entrez]
PHST- 2010/02/25 06:00 [pubmed]
PHST- 2010/05/11 06:00 [medline]
AID - 1741-7015-8-15 [pii]
AID - 10.1186/1741-7015-8-15 [doi]
PST - epublish
SO  - BMC Med. 2010 Feb 23;8:15. doi: 10.1186/1741-7015-8-15.


PMID- 20075873
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20100224
LR  - 20100115
IS  - 1476-4687 (Electronic)
IS  - 0028-0836 (Linking)
VI  - 463
IP  - 7278
DP  - 2010 Jan 14
TI  - Security ethics.
PG  - 136
LID - 10.1038/463136a [doi]
LA  - eng
PT  - Editorial
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
EDAT- 2010/02/25 06:00
MHDA- 2010/02/25 06:01
CRDT- 2010/01/16 06:00
PHST- 2010/01/16 06:00 [entrez]
PHST- 2010/02/25 06:00 [pubmed]
PHST- 2010/02/25 06:01 [medline]
AID - 463136a [pii]
AID - 10.1038/463136a [doi]
PST - ppublish
SO  - Nature. 2010 Jan 14;463(7278):136. doi: 10.1038/463136a.


PMID- 20177998
OWN - NLM
STAT- MEDLINE
DCOM- 20100708
LR  - 20211020
IS  - 1543-706X (Electronic)
IS  - 1071-2690 (Linking)
VI  - 46
IP  - 3-4
DP  - 2010 Apr
TI  - The generation of GLP-grade human embryonic stem cell banks from four
      clinical-grade cell lines for preclinical research.
PG  - 210-6
LID - 10.1007/s11626-010-9287-1 [doi]
AB  - The Singapore Stem Cell Bank has generated human embryonic stem cell banks from
      clinical-grade cell lines ESI-017, ESI-035, ESI-049, and ESI-053. All banks were 
      prepared and characterized according to principles of Good Laboratory Practice
      for quality assurance. Importantly, each cell line has clearly documented and
      approved ethical provenance and meets recognized standards for performance and
      safety. The banks are intended to facilitate the translation of stem cell
      research to clinical medicine by enabling early phase research and development
      with high-quality, low-cost cells that are also available as clinical-grade
      stocks.
FAU - Sivarajah, Shirani
AU  - Sivarajah S
AD  - Singapore Stem Cell Bank, Singapore Stem Cell Consortium, A*STAR, Singapore,
      Singapore.
FAU - Raj, Grace Selva
AU  - Raj GS
FAU - Mathews, Adam Joshua Varughese
AU  - Mathews AJ
FAU - Sahib, Norliza Binte Esmail
AU  - Sahib NB
FAU - Hwang, Wei Sek
AU  - Hwang WS
FAU - Crook, Jeremy Micah
AU  - Crook JM
LA  - eng
PT  - Journal Article
DEP - 20100223
PL  - Germany
TA  - In Vitro Cell Dev Biol Anim
JT  - In vitro cellular & developmental biology. Animal
JID - 9418515
RN  - 0 (Biomarkers)
SB  - IM
MH  - Biomarkers/metabolism
MH  - Cell Culture Techniques/*methods
MH  - Cell Differentiation/genetics
MH  - Cell Line
MH  - *Embryo Research
MH  - Embryonic Stem Cells/*cytology
MH  - Flow Cytometry
MH  - Gene Expression Regulation, Developmental
MH  - Humans
MH  - Immunohistochemistry
MH  - Karyotyping
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Tissue Banks/*standards
EDAT- 2010/02/24 06:00
MHDA- 2010/07/09 06:00
CRDT- 2010/02/24 06:00
PHST- 2009/04/02 00:00 [received]
PHST- 2010/01/14 00:00 [accepted]
PHST- 2010/02/24 06:00 [entrez]
PHST- 2010/02/24 06:00 [pubmed]
PHST- 2010/07/09 06:00 [medline]
AID - 10.1007/s11626-010-9287-1 [doi]
PST - ppublish
SO  - In Vitro Cell Dev Biol Anim. 2010 Apr;46(3-4):210-6. doi:
      10.1007/s11626-010-9287-1. Epub 2010 Feb 23.


PMID- 20177992
OWN - NLM
STAT- MEDLINE
DCOM- 20100708
LR  - 20211020
IS  - 1543-706X (Electronic)
IS  - 1071-2690 (Linking)
VI  - 46
IP  - 3-4
DP  - 2010 Apr
TI  - International stem cell registries.
PG  - 242-6
LID - 10.1007/s11626-010-9295-1 [doi]
AB  - Rapid advances in stem cell research have led to the derivation of hundreds of
      human embryonic stem (hES) cell lines in centers throughout the world, as well as
      the development of new technologies for producing pluripotent stem cells. These
      cell lines have unique characteristics and were derived using a variety of
      ethical guidelines. Stem cell registries have been developed in order to collect,
      organize, and disseminate cell line-specific information. In this review, we
      describe the current state of the field by providing an overview of the unique
      qualities and mandates of the three major stem cell registries: the European hES 
      Cell Registry, the Registry of hES Cell Line Provenance developed by the
      International Society for Stem Cell Research, and the International Stem Cell
      Registry of hES and induced pluripotent stem cell lines established at the
      University of Massachusetts Medical School. While each registry has its own
      unique mandate and features, there is some overlap in the goals and information
      provided. This review discusses the challenges and prospects for an integrated
      approach in which all three registries effectively collaborate to minimize
      duplication and facilitate information exchange within the stem cell community.
FAU - Borstlap, Joeri
AU  - Borstlap J
AD  - Berlin-Brandenburg Center for Regenerative Therapies, CellNet Group, Berlin,
      Germany.
FAU - Luong, Mai X
AU  - Luong MX
FAU - Rooke, Heather M
AU  - Rooke HM
FAU - Aran, B
AU  - Aran B
FAU - Damaschun, A
AU  - Damaschun A
FAU - Elstner, A
AU  - Elstner A
FAU - Smith, Kelly P
AU  - Smith KP
FAU - Stein, Gary S
AU  - Stein GS
FAU - Veiga, Anna
AU  - Veiga A
LA  - eng
GR  - R01 CA139322/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100223
PL  - Germany
TA  - In Vitro Cell Dev Biol Anim
JT  - In vitro cellular & developmental biology. Animal
JID - 9418515
SB  - IM
MH  - Animals
MH  - Cell Line
MH  - Embryonic Stem Cells/*cytology
MH  - Humans
MH  - *International Cooperation
MH  - *Registries
MH  - Schools, Medical
RF  - 6
EDAT- 2010/02/24 06:00
MHDA- 2010/07/09 06:00
CRDT- 2010/02/24 06:00
PHST- 2009/08/24 00:00 [received]
PHST- 2010/01/14 00:00 [accepted]
PHST- 2010/02/24 06:00 [entrez]
PHST- 2010/02/24 06:00 [pubmed]
PHST- 2010/07/09 06:00 [medline]
AID - 10.1007/s11626-010-9295-1 [doi]
PST - ppublish
SO  - In Vitro Cell Dev Biol Anim. 2010 Apr;46(3-4):242-6. doi:
      10.1007/s11626-010-9295-1. Epub 2010 Feb 23.


PMID- 20177968
OWN - NLM
STAT- MEDLINE
DCOM- 20100806
LR  - 20211020
IS  - 1573-6709 (Electronic)
IS  - 0033-2720 (Linking)
VI  - 81
IP  - 2
DP  - 2010 Jun
TI  - Tarasoff duties in prisons: community standards with certain twists.
PG  - 177-82
LID - 10.1007/s11126-010-9127-1 [doi]
AB  - Because inmates' actions are restricted by incarceration, Tarasoff duties in
      prisons have certain unique aspects. There are two broad situations: (1) when the
      potential victim is located within the prison community; and (2) when the
      potential victim is located outside of prison. Although responsibilities vary
      widely from state to state, this paper discusses general principles of exercising
      Tarasoff duties in prison settings. In addition to duties to protect potential
      victims, correctional mental-health professionals have an ethical duty to protect
      patient confidentiality. Professionals should chose Tarasoff options that protect
      confidentiality to the fullest extent possible, and prisoners should be informed 
      of situations where confidentiality does not exist. A caveat is that no Tarasoff 
      statutes can be relied upon to offer tort protection to correctional clinicians
      until they have been tested in appellate courts.
FAU - Pinta, Emil R
AU  - Pinta ER
AD  - Department of Psychiatry, The Ohio State University College of Medicine,
      Columbus, OH, USA. scritchpinta@prodigy.net
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Psychiatr Q
JT  - The Psychiatric quarterly
JID - 0376465
SB  - IM
MH  - *Confidentiality/ethics/legislation & jurisprudence
MH  - Crime Victims/legislation & jurisprudence
MH  - *Duty to Warn/ethics/legislation & jurisprudence
MH  - *Forensic Psychiatry/ethics/legislation & jurisprudence/standards
MH  - Humans
MH  - Ohio
MH  - Physician-Patient Relations/ethics
MH  - *Prisons/ethics/legislation & jurisprudence
EDAT- 2010/02/24 06:00
MHDA- 2010/08/07 06:00
CRDT- 2010/02/24 06:00
PHST- 2010/02/24 06:00 [entrez]
PHST- 2010/02/24 06:00 [pubmed]
PHST- 2010/08/07 06:00 [medline]
AID - 10.1007/s11126-010-9127-1 [doi]
PST - ppublish
SO  - Psychiatr Q. 2010 Jun;81(2):177-82. doi: 10.1007/s11126-010-9127-1.


PMID- 20177919
OWN - NLM
STAT- MEDLINE
DCOM- 20110203
LR  - 20220318
IS  - 1432-2218 (Electronic)
IS  - 0930-2794 (Linking)
VI  - 24
IP  - 9
DP  - 2010 Sep
TI  - Video. Transumbilical single-incision laparoscopic surgery for sigmoid colon
      cancer.
PG  - 2321
LID - 10.1007/s00464-010-0948-7 [doi]
AB  - BACKGROUND: Transumbilical single-incision laparoscopic surgery is an emerging
      concept that could offer excellent cosmetic results [1]. The authors describe an 
      index case of curatively intended resection of early-stage sigmoid colon cancer
      using this technique [2, 3]. METHODS: A 75-year-old woman with a body mass index 
      of 24 underwent surgery by two colorectal surgeons who had hundreds of
      experiences with laparoscopic colorectal surgery. Three 5-mm ports were placed
      linearly in the vertical 2-cm skin incision in the umbilicus. Almost all the
      procedures were performed with usual laparoscopic instruments such as a 5-mm
      flexible laparoscope and the Harmonic ACE (Ethicon Endo-Surgery, Cincinnati, OH, 
      USA). Also, the operative procedures were much the same as in usual laparoscopic 
      surgery. The sigmoid colon was mobilized using a medial approach. Then the root
      of the superior rectal artery and inferior mesenteric vein were divided using the
      EnSeal tissue sealing and hemostasis system (SurgRx, Inc. Redwood City, CA, USA).
      Low-profile trocars were mandatory to minimize interferences among instruments.
      The rectum was divided 5 cm distal to the lesion with one firing of an endoscopic
      stapler. The specimen was extracted through a 2-cm transumbilical laparotomy.
      End-to-side anastomosis using a circular stapler was performed intraabdominally, 
      and air tightness was confirmed by the anastomotic leak test. RESULTS: The
      operative time was 192 min. There was no intra- or postoperative morbidity.
      Altogether, 20 cm of sigmoid was resected with negative tumor margins, and 14
      lymph nodes were harvested. The patient started receiving meals and was
      discharged on postoperative days 2 and 7, respectively. The final pathology
      showed Tis, N0, M0, stage 0. The scar was invisible at 1 month. CONCLUSION:
      Single-incision laparoscopic colectomy is feasible and safe for selected patients
      and gives a favorable cosmetic result. By well-trained surgeons, this technique
      could be a realistic option for colorectal cancer surgery.
FAU - Takemasa, Ichiro
AU  - Takemasa I
AD  - Department of Surgery, Graduate School of Medicine, Osaka University, Suita,
      Osaka 565-0871, Japan. itakemasa@gesurg.med.osaka-u.ac.jp
FAU - Sekimoto, Mitsugu
AU  - Sekimoto M
FAU - Ikeda, Masataka
AU  - Ikeda M
FAU - Mizushima, Tsunekazu
AU  - Mizushima T
FAU - Yamamoto, Hirofumi
AU  - Yamamoto H
FAU - Doki, Yuichiro
AU  - Doki Y
FAU - Mori, Masaki
AU  - Mori M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Video-Audio Media
DEP - 20100223
PL  - Germany
TA  - Surg Endosc
JT  - Surgical endoscopy
JID - 8806653
SB  - IM
MH  - Aged
MH  - Colectomy/*methods
MH  - Colon, Sigmoid/pathology/*surgery
MH  - Colonic Neoplasms/pathology/*surgery
MH  - Female
MH  - Humans
MH  - Laparoscopy/*methods
MH  - Neoplasm Staging
MH  - Umbilicus
EDAT- 2010/02/24 06:00
MHDA- 2011/02/04 06:00
CRDT- 2010/02/24 06:00
PHST- 2009/07/07 00:00 [received]
PHST- 2010/01/14 00:00 [accepted]
PHST- 2010/02/24 06:00 [entrez]
PHST- 2010/02/24 06:00 [pubmed]
PHST- 2011/02/04 06:00 [medline]
AID - 10.1007/s00464-010-0948-7 [doi]
PST - ppublish
SO  - Surg Endosc. 2010 Sep;24(9):2321. doi: 10.1007/s00464-010-0948-7. Epub 2010 Feb
      23.


PMID- 20177660
OWN - NLM
STAT- MEDLINE
DCOM- 20100610
LR  - 20211020
IS  - 1432-1238 (Electronic)
IS  - 0342-4642 (Linking)
VI  - 36
IP  - 4
DP  - 2010 Apr
TI  - Year in review in Intensive Care Medicine 2009. Part III: mechanical ventilation,
      acute lung injury and respiratory distress syndrome, pediatrics, ethics, and
      miscellanea.
PG  - 567-84
LID - 10.1007/s00134-010-1781-0 [doi]
FAU - Antonelli, Massimo
AU  - Antonelli M
AD  - Department of Intensive Care and Anesthesiology, Policlinico Universitario A.
      Gemelli, Universita Cattolica del Sacro Cuore, Rome, Italy.
      m.antonelli@rm.unicatt.it
FAU - Azoulay, Elie
AU  - Azoulay E
FAU - Bonten, Marc
AU  - Bonten M
FAU - Chastre, Jean
AU  - Chastre J
FAU - Citerio, Giuseppe
AU  - Citerio G
FAU - Conti, Giorgio
AU  - Conti G
FAU - De Backer, Daniel
AU  - De Backer D
FAU - Lemaire, Francois
AU  - Lemaire F
FAU - Gerlach, Herwig
AU  - Gerlach H
FAU - Hedenstierna, Goran
AU  - Hedenstierna G
FAU - Joannidis, Michael
AU  - Joannidis M
FAU - Macrae, Duncan
AU  - Macrae D
FAU - Mancebo, Jordi
AU  - Mancebo J
FAU - Maggiore, Salvatore M
AU  - Maggiore SM
FAU - Mebazaa, Alexandre
AU  - Mebazaa A
FAU - Preiser, Jean-Charles
AU  - Preiser JC
FAU - Pugin, Jerome
AU  - Pugin J
FAU - Wernerman, Jan
AU  - Wernerman J
FAU - Zhang, Haibo
AU  - Zhang H
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100223
PL  - United States
TA  - Intensive Care Med
JT  - Intensive care medicine
JID - 7704851
RN  - 0 (Biomarkers)
SB  - IM
MH  - Acute Lung Injury/mortality/therapy
MH  - Biomarkers/analysis
MH  - Brain Death
MH  - Critical Care/*methods
MH  - Ethics, Research
MH  - Humans
MH  - Monitoring, Physiologic/methods
MH  - Pediatrics/methods
MH  - Periodicals as Topic
MH  - Quality of Health Care
MH  - Respiration, Artificial/adverse effects/methods
MH  - Respiratory Distress Syndrome/mortality/therapy
MH  - Tissue and Organ Procurement
RF  - 116
PMC - PMC2837179
EDAT- 2010/02/24 06:00
MHDA- 2010/06/11 06:00
CRDT- 2010/02/24 06:00
PHST- 2010/02/08 00:00 [received]
PHST- 2010/02/08 00:00 [accepted]
PHST- 2010/02/24 06:00 [entrez]
PHST- 2010/02/24 06:00 [pubmed]
PHST- 2010/06/11 06:00 [medline]
AID - 10.1007/s00134-010-1781-0 [doi]
PST - ppublish
SO  - Intensive Care Med. 2010 Apr;36(4):567-84. doi: 10.1007/s00134-010-1781-0. Epub
      2010 Feb 23.


PMID- 20177306
OWN - NLM
STAT- MEDLINE
DCOM- 20100317
LR  - 20210107
IS  - 1873-233X (Electronic)
IS  - 0029-7844 (Linking)
VI  - 115
IP  - 3
DP  - 2010 Mar
TI  - Committee Opinion No. 456: Forming a just health care system.
PG  - 672-677
LID - 10.1097/AOG.0b013e3181d4ffc8 [doi]
AB  - In this Committee Opinion, the Committee on Ethics of the American College of
      Obstetricians and Gynecologists endorses the College's ongoing efforts to promote
      a just health care system, explores justifications that inform just health care, 
      and identifies professional responsibilities to guide the College and its members
      in advancing the cause of health care reform.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Obstet Gynecol
JT  - Obstetrics and gynecology
JID - 0401101
SB  - IM
MH  - Health Care Reform/*ethics
MH  - Health Services Accessibility/*ethics
MH  - Humans
MH  - Physicians
MH  - *Politics
MH  - Social Justice
MH  - United States
EDAT- 2010/02/24 06:00
MHDA- 2010/03/18 06:00
CRDT- 2010/02/24 06:00
PHST- 2010/02/24 06:00 [entrez]
PHST- 2010/02/24 06:00 [pubmed]
PHST- 2010/03/18 06:00 [medline]
AID - 10.1097/AOG.0b013e3181d4ffc8 [doi]
AID - 00006250-201003000-00034 [pii]
PST - ppublish
SO  - Obstet Gynecol. 2010 Mar;115(3):672-677. doi: 10.1097/AOG.0b013e3181d4ffc8.


PMID- 20177108
OWN - NLM
STAT- MEDLINE
DCOM- 20100415
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 254
IP  - 3
DP  - 2010 Mar
TI  - MR imaging of iron phagocytosis in intraluminal thrombi of abdominal aortic
      aneurysms in humans.
PG  - 973-81
LID - 10.1148/radiol.09090657 [doi]
AB  - PURPOSE: To prospectively determine if superparamagnetic iron oxide
      (SPIO)-enhanced magnetic resonance (MR) imaging could help visualize leukocyte
      phagocytic activities in human abdominal aortic aneurysms (AAAs). MATERIALS AND
      METHODS: This study was approved by the institutional ethics committee; all
      patients gave informed consent. Preoperative MR imaging data, including
      unenhanced and SPIO-enhanced T1-, T2*-, and T2-weighted transverse images of the 
      entire AAA, obtained 1 hour after contrast enhancement from 15 patients (mean
      age, 72.7 years +/- 8.2; range, 60-83 years), 10 men (mean age, 73.5 years +/-
      7.9; range, 60-83 years) and five women (mean age, 71.2 years +/- 9.4; range
      60-82), were retrospectively evaluated. Morphologic appearance and
      semiquantitative and contrast-to-noise ratio (CNR) analyses of the thrombi were
      performed. Thrombi were analyzed semiquantitatively at microscopy after staining 
      with hematoxylin-eosin, CD68, and CD66b. Levels of promatrix metalloproteinase
      (pro-MMP)-2 and pro-MMP-9, MMP-2 and MMP-9, and their mRNA located in the
      thrombus were assessed by using zymography and quantitative reverse transcriptase
      polymerase chain reaction analysis. Nonparametric statistics of the Spearman rank
      correlation were calculated to evaluate correlations between the aneurysm
      thrombus signal level decrease after SPIO and the levels of CD68(+), CD66b(+)
      cells, pro-MMP-2 and pro-MMP-9, MMP-2 and MMP-9, and MMP-9 mRNA. RESULTS: The
      pre-SPIO CNRs in the luminal sublayer of the thrombus and the deeper thrombus
      were -10.20 +/- 12.69 and -5.68 +/-10.38, respectively. After SPIO, the CNRs
      decreased to -21.34 +/-13.07 (P < .001) and -12.44 +/- 14.56, respectively (P <
      .012). There was a significant linear correlation between the thrombus signal
      level decrease and the levels of CD68(+) and CD66b(+) cells, pro-MMP-9, and MMP-9
      mRNA (P < .05). CONCLUSION: MR imaging allows in vivo demonstration of SPIO
      uptake at the luminal interface of the thrombus. This uptake is correlated to the
      abundance of leukocytes. SUPPLEMENTAL MATERIAL:
      http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.09090657/-/DC1.
CI  - (c) RSNA, 2010
FAU - Nchimi, Alain
AU  - Nchimi A
AD  - Departments of Medical Imaging and Pathology, Centre Hospitalier Chretien, Rue de
      Hesbaye, 75, B-4000 Liege, Belgium. alain.nchimi@chc.be
FAU - Defawe, Olivier
AU  - Defawe O
FAU - Brisbois, Denis
AU  - Brisbois D
FAU - Broussaud, Thomas K Y
AU  - Broussaud TK
FAU - Defraigne, Jean-Olivier
AU  - Defraigne JO
FAU - Magotteaux, Paul
AU  - Magotteaux P
FAU - Massart, Brigitte
AU  - Massart B
FAU - Serfaty, Jean-Michel
AU  - Serfaty JM
FAU - Houard, Xavier
AU  - Houard X
FAU - Michel, Jean-Baptiste
AU  - Michel JB
FAU - Sakalihasan, Natzi
AU  - Sakalihasan N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - 0 (Dextrans)
RN  - 0 (Enzyme Precursors)
RN  - 0 (Magnetite Nanoparticles)
RN  - EC 3.4.21.- (Serine Endopeptidases)
RN  - EC 3.4.21.- (pro-MMP-9 activator)
RN  - EC 3.4.24.- (Gelatinases)
RN  - EC 3.4.24.- (progelatinase)
RN  - EC 3.4.24.24 (Matrix Metalloproteinase 2)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
RN  - G6N3J05W84 (ferumoxides)
RN  - XM0M87F357 (Ferrosoferric Oxide)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Analysis of Variance
MH  - Aortic Aneurysm/*metabolism/physiopathology
MH  - Contrast Media/pharmacokinetics
MH  - Dextrans
MH  - Enzyme Precursors/metabolism
MH  - Female
MH  - Ferrosoferric Oxide/pharmacokinetics
MH  - Gelatinases/metabolism
MH  - Humans
MH  - Image Enhancement/methods
MH  - Immunohistochemistry
MH  - Magnetic Resonance Imaging/*methods
MH  - Magnetite Nanoparticles
MH  - Male
MH  - Matrix Metalloproteinase 2/metabolism
MH  - Matrix Metalloproteinase 9/metabolism
MH  - Middle Aged
MH  - Phagocytosis/*physiology
MH  - Prospective Studies
MH  - Retrospective Studies
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Serine Endopeptidases/metabolism
MH  - Statistics, Nonparametric
MH  - Thrombosis/*metabolism/physiopathology
EDAT- 2010/02/24 06:00
MHDA- 2010/04/16 06:00
CRDT- 2010/02/24 06:00
PHST- 2010/02/24 06:00 [entrez]
PHST- 2010/02/24 06:00 [pubmed]
PHST- 2010/04/16 06:00 [medline]
AID - 254/3/973 [pii]
AID - 10.1148/radiol.09090657 [doi]
PST - ppublish
SO  - Radiology. 2010 Mar;254(3):973-81. doi: 10.1148/radiol.09090657.


PMID- 20177099
OWN - NLM
STAT- MEDLINE
DCOM- 20100415
LR  - 20220331
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 254
IP  - 3
DP  - 2010 Mar
TI  - Percutaneous vertebroplasty for pain management in malignant fractures of the
      spine with epidural involvement.
PG  - 882-90
LID - 10.1148/radiol.09081698 [doi]
AB  - PURPOSE: To evaluate the feasibility, efficacy, and safety of percutaneous
      vertebroplasty (PV) in the treatment of pathologic fractures owing to malignancy 
      with epidural involvement, with or without neurologic symptoms of spinal cord or 
      cauda equina compression. MATERIALS AND METHODS: This study was approved by the
      local ethics committee; informed consent was obtained from all patients. This
      retrospective review was performed for 51 consecutive patients with metastatic
      disease or multiple myeloma treated by means of vertebroplasty, who presented
      with at least one vertebral lesion with epidural involvement, with or without
      clinical symptoms of spinal cord or cauda equina compression. All patients with
      neurologic deficit were terminally ill. A neurologic examination was performed
      before and after treatment in all patients. All imaging examinations and
      treatments were reviewed, and chi(2), Mann Whitney, or Fisher exact testing was
      performed for univariate analysis of variables. RESULTS: A total of 74 vertebrae 
      were treated in 51 patients, 22 women and 29 men with a mean age of 62.5 years
      (range, 28-85 years). Fifteen (29%) patients presented symptoms of complete or
      incomplete spinal cord or cauda equina compression before vertebroplasty and no
      further clinical deterioration was observed after treatment. The analgesic
      efficacy of vertebroplasty was satisfactory for 94% (48 of 51) of patients after 
      1 day, 86% (31 of 36) patients after 1 month, and 92% (11 of 12) patients after 1
      year. One patient with no clinical neurologic deficit before treatment
      experienced symptoms of cauda equina compression 2 days after vertebroplasty. No 
      other major complication was observed. CONCLUSION: The feasibility, efficacy, and
      safety of PV were confirmed in patients experiencing pain related to malignant
      spinal tumors with epidural extension, with a low complication rate. PV should
      become part of the palliative analgesic treatment for such patients. (c) RSNA,
      2010.
FAU - Saliou, Guillaume
AU  - Saliou G
AD  - Department of Neuroradiology, Hopital Nord, 2 place Victor Pauchet, 80054 Amiens,
      France.
FAU - Kocheida, El Moncef
AU  - Kocheida el M
FAU - Lehmann, Pierre
AU  - Lehmann P
FAU - Depriester, Claude
AU  - Depriester C
FAU - Paradot, Gaelle
AU  - Paradot G
FAU - Le Gars, Daniel
AU  - Le Gars D
FAU - Balut, Antonia
AU  - Balut A
FAU - Deramond, Herve
AU  - Deramond H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Bone Cements)
SB  - IM
CIN - Radiology. 2010 Dec;257(3):894; author reply 894-5. PMID: 21084421
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Bone Cements
MH  - Chi-Square Distribution
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Invasiveness
MH  - Pain/etiology/*surgery
MH  - Pain Measurement
MH  - Retrospective Studies
MH  - Spinal Fractures/diagnostic imaging/etiology/pathology/*surgery
MH  - Spinal Neoplasms/complications/diagnostic imaging/pathology/*surgery
MH  - Statistics, Nonparametric
MH  - Tomography, X-Ray Computed
MH  - Treatment Outcome
MH  - Vertebroplasty/*methods
EDAT- 2010/02/24 06:00
MHDA- 2010/04/16 06:00
CRDT- 2010/02/24 06:00
PHST- 2010/02/24 06:00 [entrez]
PHST- 2010/02/24 06:00 [pubmed]
PHST- 2010/04/16 06:00 [medline]
AID - 254/3/882 [pii]
AID - 10.1148/radiol.09081698 [doi]
PST - ppublish
SO  - Radiology. 2010 Mar;254(3):882-90. doi: 10.1148/radiol.09081698.


PMID- 20177089
OWN - NLM
STAT- MEDLINE
DCOM- 20100415
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 254
IP  - 3
DP  - 2010 Mar
TI  - Reduced bone perfusion in osteoporosis: likely causes in an ovariectomy rat
      model.
PG  - 739-46
LID - 10.1148/radiol.09090608 [doi]
AB  - PURPOSE: To investigate the cause of reduced vertebral perfusion in a rat
      ovariectomy model. MATERIALS AND METHODS: Experimental protocol was approved by
      the local Animal Experiment Ethics Committee. Twenty-two Sprague-Dawley rats were
      studied. Computed tomographic bone densitometry and magnetic resonance perfusion 
      imaging were performed at baseline and 2, 4, and 8 weeks after ovariectomy (n =
      11) or sham surgery (n = 11). Perfusion parameters analyzed were maximum
      enhancement (E(max)) and enhancement slope (E(slope)). After the animals were
      sacrificed, the aorta and femoral artery were analyzed for vessel reactivity, and
      the lumbar vertebrae were analyzed for marrow content. RESULTS: In control rats, 
      bone mineral density (BMD), E(max), and E(slope) remained constant. In
      ovariectomy rats, a comparable reduction in BMD and the perfusion parameters at
      two weeks post-ovariectomy (BMD, 9.3%; E(max), 11.6%; E(slope), 9%) was seen 2
      weeks after ovariectomy, and further reductions were seen 4 weeks (BMD, 17.5%;
      E(max), 15.6%; E(slope), 33%) and 8 weeks (BMD, 18.8%; E(max), 14.2%; E(slope),
      33%) after ovariectomy. Endothelial dysfunction was observed in both the aorta
      and femoral artery of the ovariectomy group but not of the control group.
      Increased marrow fat area was seen in the ovariectomy group (52.9% vs 21.6%; P < 
      .01) owing to an increase in fat cell number. Decreased erythropoetic marrow area
      (32.5% vs 48.6%; P < .05) was also observed in the ovariectomy group. CONCLUSION:
      Reduced bone perfusion occurs in synchrony with reduced BMD. The most likely
      causes of reduced bone perfusion are a reduction in the amount of erythropoetic
      marrow and endothelial dysfunction after ovariectomy. SUPPLEMENTAL MATERIAL:
      http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.09090608/-/DC1.
CI  - (c) RSNA, 2010
FAU - Griffith, James F
AU  - Griffith JF
AD  - Departments of Diagnostic Radiology and Organ Imaging, Anatomy, Physiology, and
      Orthopedics and Traumatology, Prince of Wales Hospital, Chinese University of
      Hong Kong, Shatin, NT, Hong Kong. griffith@cuhk.edu.hk
FAU - Wang, Yi-Xiang J
AU  - Wang YX
FAU - Zhou, Hua
AU  - Zhou H
FAU - Kwong, Wing Hang
AU  - Kwong WH
FAU - Wong, Wing Tak
AU  - Wong WT
FAU - Sun, Yan-Lin
AU  - Sun YL
FAU - Huang, Yu
AU  - Huang Y
FAU - Yeung, David K W
AU  - Yeung DK
FAU - Qin, Ling
AU  - Qin L
FAU - Ahuja, Anil T
AU  - Ahuja AT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 6HG8UB2MUY (Meglumine)
RN  - L0ND3981AG (gadoterate meglumine)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Bone Density
MH  - Contrast Media
MH  - Female
MH  - Image Processing, Computer-Assisted
MH  - Lumbar Vertebrae/*blood supply/diagnostic imaging/*pathology
MH  - Magnetic Resonance Imaging
MH  - Meglumine
MH  - Organometallic Compounds
MH  - Osteoporosis/*pathology
MH  - *Ovariectomy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Statistics, Nonparametric
MH  - Tomography, X-Ray Computed
EDAT- 2010/02/24 06:00
MHDA- 2010/04/16 06:00
CRDT- 2010/02/24 06:00
PHST- 2010/02/24 06:00 [entrez]
PHST- 2010/02/24 06:00 [pubmed]
PHST- 2010/04/16 06:00 [medline]
AID - 254/3/739 [pii]
AID - 10.1148/radiol.09090608 [doi]
PST - ppublish
SO  - Radiology. 2010 Mar;254(3):739-46. doi: 10.1148/radiol.09090608.


PMID- 20176694
OWN - NLM
STAT- MEDLINE
DCOM- 20100513
LR  - 20220321
IS  - 1569-8041 (Electronic)
IS  - 0923-7534 (Linking)
VI  - 21
IP  - 3
DP  - 2010 Mar
TI  - Formulary availability and regulatory barriers to accessibility of opioids for
      cancer pain in Europe: a report from the ESMO/EAPC Opioid Policy Initiative.
PG  - 615-626
LID - S0923-7534(19)38330-9 [pii]
LID - 10.1093/annonc/mdp581 [doi]
AB  - BACKGROUND: Many patients in Europe do not receive adequate relief of pain
      because of excessive regulatory restrictions on the availability and
      accessibility of opioids. This is a major public health problem. The aim of the
      study is to evaluate and report on opioid availability and the legal and
      regulatory barriers to accessibility across the countries of Europe. METHODS:
      European Society for Medical Oncology and European Association for Palliative
      Care national representatives reported data regarding survey of opioid
      availability and accessibility. Formulary adequacy is evaluated relative to the
      World Health Organization (WHO) essential drugs list and the International
      Association for Hospice and Palliative Care list of essential medicines for
      palliative care. Overregulation is evaluated according to the guidelines for
      assessment of national opioid regulations of the WHO. RESULTS: Data were reported
      on the availability and accessibility of opioids for the management of cancer
      pain in 21 Eastern European countries and 20 Western European countries. Results 
      are presented describing the availability and cost of opioids for cancer pain in 
      each surveyed country and nine forms of regulatory restrictions. CONCLUSIONS:
      Using standards derived from the WHO and International Narcotics Control Board,
      this survey has exposed formulary deficiencies and excessive regulatory barriers 
      that interfere with appropriate patient care in many European countries. There is
      an ethical and public health imperative to address these issues.
FAU - Cherny, N I
AU  - Cherny NI
AD  - Cancer Pain and Palliative Medicine Unit, Department of Oncology, Shaare Zedek
      Medical Center, Jerusalem, Israel; European Society for Medical Oncology;
      Palliative Care Working Group. Electronic address: nathancherny@yahoo.com.
FAU - Baselga, J
AU  - Baselga J
AD  - Medical Oncology Service, Vall d'Hebron University Hospital, Barcelona, Spain;
      European Society for Medical Oncology.
FAU - de Conno, F
AU  - de Conno F
AD  - European Association for Palliative Care.
FAU - Radbruch, L
AU  - Radbruch L
AD  - European Association for Palliative Care; Palliative Medicine, Aachen University,
      Aachen, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Ann Oncol
JT  - Annals of oncology : official journal of the European Society for Medical
      Oncology
JID - 9007735
RN  - 0 (Analgesics, Opioid)
SB  - IM
MH  - Analgesics, Opioid/*supply & distribution/therapeutic use
MH  - Drug and Narcotic Control/*legislation & jurisprudence
MH  - Europe
MH  - Formularies as Topic
MH  - Health Policy/*legislation & jurisprudence
MH  - Health Services Accessibility/*legislation & jurisprudence
MH  - Humans
MH  - International Cooperation
MH  - Neoplasms/*complications
MH  - Outcome Assessment, Health Care
MH  - Pain/*drug therapy
MH  - Palliative Care/*legislation & jurisprudence/organization &
      administration/statistics & numerical data
MH  - Practice Guidelines as Topic
MH  - Quality of Life
MH  - Survival Rate
MH  - World Health Organization
EDAT- 2010/02/24 06:00
MHDA- 2010/05/14 06:00
CRDT- 2010/02/24 06:00
PHST- 2010/02/24 06:00 [entrez]
PHST- 2010/02/24 06:00 [pubmed]
PHST- 2010/05/14 06:00 [medline]
AID - S0923-7534(19)38330-9 [pii]
AID - 10.1093/annonc/mdp581 [doi]
PST - ppublish
SO  - Ann Oncol. 2010 Mar;21(3):615-626. doi: 10.1093/annonc/mdp581.


PMID- 20175394
OWN - NLM
STAT- MEDLINE
DCOM- 20100319
LR  - 20211020
IS  - 0161-8105 (Print)
IS  - 0161-8105 (Linking)
VI  - 33
IP  - 2
DP  - 2010 Feb
TI  - Ethical integrity is the sine qua non of scientific reporting.
PG  - 141-2
FAU - Dinges, David F
AU  - Dinges DF
LA  - eng
PT  - Editorial
PL  - United States
TA  - Sleep
JT  - Sleep
JID - 7809084
SB  - IM
MH  - *Authorship
MH  - *Conflict of Interest
MH  - Disclosure/*ethics
MH  - *Editorial Policies
MH  - Humans
MH  - Periodicals as Topic/*ethics
MH  - *Sleep
MH  - United States
PMC - PMC2817898
EDAT- 2010/02/24 06:00
MHDA- 2010/03/20 06:00
CRDT- 2010/02/24 06:00
PHST- 2010/02/24 06:00 [entrez]
PHST- 2010/02/24 06:00 [pubmed]
PHST- 2010/03/20 06:00 [medline]
AID - 10.1093/sleep/33.2.141 [doi]
PST - ppublish
SO  - Sleep. 2010 Feb;33(2):141-2. doi: 10.1093/sleep/33.2.141.


PMID- 20174615
OWN - NLM
STAT- MEDLINE
DCOM- 20100804
LR  - 20220408
IS  - 1087-2981 (Electronic)
IS  - 1087-2981 (Linking)
VI  - 15
DP  - 2010 Jan 29
TI  - Effectiveness of an online curriculum for medical students on genetics, genetic
      testing and counseling.
LID - 10.3402/meo.v15i0.4856 [doi]
AB  - BACKGROUND: It is increasingly important that physicians have a thorough
      understanding of the basic science of human genetics and the ethical, legal and
      social implications (ELSI) associated with genetic testing and counseling.
      METHODS: The authors developed a series of web-based courses for medical students
      on these topics. The course modules are interactive, emphasize clinical case
      studies, and can easily be incorporated into existing medical school curricula.
      RESULTS: Results of a 'real world' effectiveness trial indicate that the courses 
      have a statistically significant effect on knowledge, attitude, intended behavior
      and self-efficacy related to genetic testing (p<0.001; N varies between 163 and
      596 for each course). CONCLUSIONS: The results indicate that this curriculum is
      an effective tool for educating medical students on the ELSI associated with
      genetic testing and for promoting positive changes in students' confidence,
      counseling attitudes and behaviors.
FAU - Metcalf, Mary P
AU  - Metcalf MP
AD  - Clinical Tools Inc., 1506 E. Franklin Street #200, Chapel Hill, NC, USA.
      metcalf@clinicaltools.com
FAU - Tanner, T Bradley
AU  - Tanner TB
FAU - Buchanan, Amanda
AU  - Buchanan A
LA  - eng
GR  - R25 HG002266/HG/NHGRI NIH HHS/United States
GR  - R25-HG 02266/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100129
PL  - United States
TA  - Med Educ Online
JT  - Medical education online
JID - 9806550
SB  - IM
MH  - Computer-Assisted Instruction/*methods
MH  - *Curriculum
MH  - Education, Medical/*methods
MH  - *Genetic Testing
MH  - Genetics, Medical/*education
MH  - Humans
MH  - *Internet
MH  - Program Evaluation
MH  - Students, Medical
MH  - Technology Assessment, Biomedical
MH  - United States
PMC - PMC2823389
OTO - NOTNLM
OT  - ELSI
OT  - genetics
OT  - medical school curriculum
OT  - online education
EDAT- 2010/02/23 06:00
MHDA- 2010/08/05 06:00
CRDT- 2010/02/23 06:00
PHST- 2009/09/08 00:00 [received]
PHST- 2009/12/21 00:00 [revised]
PHST- 2009/12/21 00:00 [accepted]
PHST- 2010/02/23 06:00 [entrez]
PHST- 2010/02/23 06:00 [pubmed]
PHST- 2010/08/05 06:00 [medline]
AID - 10.3402/meo.v15i0.4856 [doi]
PST - epublish
SO  - Med Educ Online. 2010 Jan 29;15. doi: 10.3402/meo.v15i0.4856.


PMID- 20173787
OWN - NLM
STAT- MEDLINE
DCOM- 20101216
LR  - 20100512
IS  - 1476-5365 (Electronic)
IS  - 0268-3369 (Linking)
VI  - 45
IP  - 5
DP  - 2010 May
TI  - Donor safety: the role of the WMDA in ensuring the safety of volunteer unrelated 
      donors: clinical and ethical considerations.
PG  - 832-8
LID - 10.1038/bmt.2010.2 [doi]
AB  - Since the beginning of hematopoietic stem cell harvesting from volunteer
      unrelated donors, ensuring donor safety has been a necessary goal of all parties 
      involved in the process. As donation of BM or PBSCs is not in the interest of the
      donor's own physical health, donor registries and transplantation centers must
      take into account both medical and ethical aspects involved in the donation
      procedure. One of the principal goals leading to the formation of the World
      Marrow Donor Association (WMDA) was to establish internationally acceptable
      standards for all aspects of unrelated donor care.
FAU - Shaw, B E
AU  - Shaw BE
AD  - Department of Haematology, Anthony Nolan Trust, Royal Free Hospital, London, UK. 
      Bronwen.Shaw@icr.ac.uk
FAU - Ball, L
AU  - Ball L
FAU - Beksac, M
AU  - Beksac M
FAU - Bengtsson, M
AU  - Bengtsson M
FAU - Confer, D
AU  - Confer D
FAU - Diler, S
AU  - Diler S
FAU - Fechter, M
AU  - Fechter M
FAU - Greinix, H
AU  - Greinix H
FAU - Koh, M
AU  - Koh M
FAU - Lee, S
AU  - Lee S
FAU - Nicoloso-De-Faveri, G
AU  - Nicoloso-De-Faveri G
FAU - Philippe, J
AU  - Philippe J
FAU - Pollichieni, S
AU  - Pollichieni S
FAU - Pulsipher, M
AU  - Pulsipher M
FAU - Schmidt, A
AU  - Schmidt A
FAU - Yang, E
AU  - Yang E
FAU - van Walraven, A-M
AU  - van Walraven AM
CN  - Clinical Working Group
CN  - Ethics Working Group of the WMDA
LA  - eng
PT  - Journal Article
DEP - 20100222
PL  - England
TA  - Bone Marrow Transplant
JT  - Bone marrow transplantation
JID - 8702459
SB  - IM
MH  - Health Care Coalitions
MH  - Hematopoietic Stem Cell Transplantation/ethics/*standards
MH  - Humans
MH  - *Internationality
MH  - Registries/standards
MH  - *Safety
MH  - *Tissue Donors/ethics
MH  - Tissue and Organ Procurement/*ethics/organization & administration/*standards
MH  - Transplantation, Homologous
EDAT- 2010/02/23 06:00
MHDA- 2010/12/17 06:00
CRDT- 2010/02/23 06:00
PHST- 2010/02/23 06:00 [entrez]
PHST- 2010/02/23 06:00 [pubmed]
PHST- 2010/12/17 06:00 [medline]
AID - bmt20102 [pii]
AID - 10.1038/bmt.2010.2 [doi]
PST - ppublish
SO  - Bone Marrow Transplant. 2010 May;45(5):832-8. doi: 10.1038/bmt.2010.2. Epub 2010 
      Feb 22.


PMID- 20173779
OWN - NLM
STAT- MEDLINE
DCOM- 20100521
LR  - 20211020
IS  - 1759-5037 (Electronic)
IS  - 1759-5029 (Linking)
VI  - 6
IP  - 3
DP  - 2010 Mar
TI  - Stem cell and gene therapies for diabetes mellitus.
PG  - 173-7
LID - 10.1038/nrendo.2009.276 [doi]
AB  - In this Perspectives article, we comment on the progress in experimental stem
      cell and gene therapies that might one day become a clinical reality for the
      treatment of patients with diabetes mellitus. Research on the ability of human
      embryonic stem cells to differentiate into islet cells has defined the
      developmental stages and transcription factors involved in this process. However,
      the clinical applications of human embryonic stem cells are limited by ethical
      concerns, as well as the potential for teratoma formation. As a consequence,
      alternative forms of stem cell therapies, such as induced pluripotent stem cells 
      and bone marrow-derived mesenchymal stem cells, have become an area of intense
      study. Finally, gene therapy shows some promise for the generation of
      insulin-producing cells. Here, we discuss two of the most frequently used
      approaches: in vitro gene delivery into cells which are then transplanted into
      the recipient and direct delivery of genes in vivo.
FAU - Calne, Roy Y
AU  - Calne RY
AD  - Department of Medicine, Strangeways Research Laboratory, 2 Wort's Causeway,
      Cambridge CB1 8RN, UK. calne@hermes.cam.ac.uk
FAU - Gan, Shu Uin
AU  - Gan SU
FAU - Lee, Kok Onn
AU  - Lee KO
LA  - eng
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Nat Rev Endocrinol
JT  - Nature reviews. Endocrinology
JID - 101500078
SB  - IM
MH  - Animals
MH  - Diabetes Mellitus/*therapy
MH  - Genetic Therapy/*methods
MH  - Humans
MH  - Stem Cell Transplantation/*methods
EDAT- 2010/02/23 06:00
MHDA- 2010/05/22 06:00
CRDT- 2010/02/23 06:00
PHST- 2010/02/23 06:00 [entrez]
PHST- 2010/02/23 06:00 [pubmed]
PHST- 2010/05/22 06:00 [medline]
AID - nrendo.2009.276 [pii]
AID - 10.1038/nrendo.2009.276 [doi]
PST - ppublish
SO  - Nat Rev Endocrinol. 2010 Mar;6(3):173-7. doi: 10.1038/nrendo.2009.276.


PMID- 20173298
OWN - NLM
STAT- MEDLINE
DCOM- 20100916
LR  - 20101109
IS  - 1529-8795 (Electronic)
IS  - 0031-5982 (Linking)
VI  - 53
IP  - 1
DP  - 2010 Winter
TI  - Medical education as moral formation: an Aristotelian account of medical
      professionalsim.
PG  - 87-105
LID - 10.1353/pbm.0.0145 [doi]
AB  - The medical professionalism movement, bolstered by many influential medical
      organizations and institutions, has in the last decade produced a number of
      conceptual definitions of professionalism and a number of concrete proposals for 
      its measurement and teaching. These projects, however laudable, are misguided
      when they treat professionalism as a unitary descriptive concept rather than as a
      contested and therefore primarily evaluative one; when they conceive
      professionalism as a domain of medical practice separable in principle from other
      domains; and when they treat professionalism as, in principle, a specifiable goal
      or product of sufficiently well designed educational curricula. The logic of
      professionalism-as-product corresponds to the logic of techne (art or practical
      skill) in Aristotle's Nicomachean Ethics. Aristotle provides a cogent argument,
      however, that the moral excellences denoted by "professionalism" cannot be
      "produced" or even prespecified in the concrete; rather, they must be acquired
      through long practice under the careful concrete guidance of teachers who
      themselves embody these moral excellences. Phronesis (practical wisdom) rather
      than techne must therefore be the guiding logic of educational initiatives in
      medical professional formation, with particular emphasis on close mentorship and 
      on the moral character both of students and of those who teach them.
FAU - Kinghorn, Warren A
AU  - Kinghorn WA
AD  - DurhamVA Medical Center, Duke Divinity School, Durham, NC 27705,USA.
      warren.kinghorn@duke.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Perspect Biol Med
JT  - Perspectives in biology and medicine
JID - 0401132
SB  - IM
MH  - Attitude of Health Personnel
MH  - Education, Medical/*ethics/methods
MH  - *Ethics, Medical
MH  - Humans
MH  - Morals
MH  - *Philosophy, Medical
MH  - *Physician's Role
MH  - Physicians/*ethics/psychology
MH  - Professional Competence
EDAT- 2010/02/23 06:00
MHDA- 2010/09/18 06:00
CRDT- 2010/02/23 06:00
PHST- 2010/02/23 06:00 [entrez]
PHST- 2010/02/23 06:00 [pubmed]
PHST- 2010/09/18 06:00 [medline]
AID - S1529879509100078 [pii]
AID - 10.1353/pbm.0.0145 [doi]
PST - ppublish
SO  - Perspect Biol Med. 2010 Winter;53(1):87-105. doi: 10.1353/pbm.0.0145.


PMID- 20173296
OWN - NLM
STAT- MEDLINE
DCOM- 20100916
LR  - 20151119
IS  - 1529-8795 (Electronic)
IS  - 0031-5982 (Linking)
VI  - 53
IP  - 1
DP  - 2010 Winter
TI  - Propranolol use in the prevention and treatment of posttraumatic stress disorder 
      in military veterans: forgetting therapy revisited.
PG  - 61-74
LID - 10.1353/pbm.0.0140 [doi]
AB  - The alarming number of military service members returning from combat suffering
      from posttraumatic stress disorder (PTSD) has stimulated research into the
      treatment and prevention of PTSD, using pharmacological agents including the
      beta-adrenergic blocker propranolol. Propranolol use has been examined in three
      phases of memory, including acquisition, formation, and encoding; emotional
      response and consolidation; and retrieval and reconsolidation. Early research
      focused on acquisition and consolidation with encouraging but inconsistent
      results, with more recent research directed towards memory reconsolidation, and
      dissociation of emotion and fear from memories. Ethical opposition to this
      research and therapy came from the President's Council on Bioethics, who argued
      in Beyond Therapy (2003) that this type of therapy disrupts sense of self, and
      from a target article and ensuing discussion in theAmerican Journal of Bioethics 
      in 2007. These arguments preceded research on the effects of propranolol on
      reconsolidation, which impacts the ethical discussion. If propranolol use in
      dissociation of emotion and fear from memory is effective in individuals with
      PTSD, much of the argument against propranolol use is moot. Veterans who cannot
      function in society due to PTSD have essentially already lost their sense of
      self. The ethical issue is not how treatment may affect them, but whether
      withholding research and treatment that may alleviate the condition is
      justifiable.
FAU - Donovan, Elise
AU  - Donovan E
AD  - Department of Health and Exercise Science, 220 Moby B Complex,Colorado State
      University, Fort, Collins, CO 80523, USA. edonovan@cahs.colostate.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Perspect Biol Med
JT  - Perspectives in biology and medicine
JID - 0401132
RN  - 0 (Adrenergic beta-Antagonists)
RN  - 9Y8NXQ24VQ (Propranolol)
SB  - IM
MH  - Adrenergic beta-Antagonists/pharmacology/*therapeutic use
MH  - *Ethics, Clinical
MH  - Humans
MH  - Memory/drug effects
MH  - Memory Disorders/chemically induced
MH  - Military Personnel/psychology
MH  - Propranolol/pharmacology/*therapeutic use
MH  - Self Concept
MH  - Stress Disorders, Post-Traumatic/*drug therapy/physiopathology/prevention &
      control
MH  - Veterans/*psychology
MH  - Warfare
EDAT- 2010/02/23 06:00
MHDA- 2010/09/18 06:00
CRDT- 2010/02/23 06:00
PHST- 2010/02/23 06:00 [entrez]
PHST- 2010/02/23 06:00 [pubmed]
PHST- 2010/09/18 06:00 [medline]
AID - S1529879509100054 [pii]
AID - 10.1353/pbm.0.0140 [doi]
PST - ppublish
SO  - Perspect Biol Med. 2010 Winter;53(1):61-74. doi: 10.1353/pbm.0.0140.


PMID- 20173295
OWN - NLM
STAT- MEDLINE
DCOM- 20100916
LR  - 20101109
IS  - 1529-8795 (Electronic)
IS  - 0031-5982 (Linking)
VI  - 53
IP  - 1
DP  - 2010 Winter
TI  - The ethics of helping transgender men and women have children.
PG  - 46-60
LID - 10.1353/pbm.0.0138 [doi]
AB  - A transgender man legally married to a woman has given birth to two children,
      raising questions about the ethics of assisted reproductive treatments (ARTs) for
      people with cross-sex identities. Psychiatry treats cross-sex identities as a
      disorder, but key medical organizations and the law in some jurisdictions have
      taken steps to protect people with these identities from discrimination in health
      care, housing, and employment. In fact, many people with cross-sex identities
      bypass psychiatric treatment altogether in order to pursue lives that are
      meaningful to them, lives that sometimes include children. Cross-sex
      identification does not render people unfit as parents, because transgender
      identities do not undercut the ability to understand the nature and consequences 
      of pregnancy or necessarily interfere with the ability to raise children.
      Moreover, no evidence suggests that being born to and raised by transgender
      parents triggers the kind of harm that would justify exclusion of
      trans-identified men and women from ARTs as a class. The normalization of
      transgender identities by the law and professional organizations contributes,
      moreover, to the need to reassess pathological interpretations of cross-sex
      identities, and trans-parenthood puts those interpretations into sharp relief.
FAU - Murphy, Timothy F
AU  - Murphy TF
AD  - Department of Medical Education,m/c 591,University of Illinois College of
      Medicine, 808 S.WoodStreet, Chicago IL 60612-7309, USA. tmurphy@uic.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Perspect Biol Med
JT  - Perspectives in biology and medicine
JID - 0401132
SB  - IM
MH  - Attitude of Health Personnel
MH  - Female
MH  - *Gender Identity
MH  - Humans
MH  - Male
MH  - Parent-Child Relations
MH  - Pregnancy
MH  - Prejudice
MH  - Reproductive Techniques, Assisted/adverse effects/*ethics
MH  - Sexuality/*psychology
MH  - Societies, Medical
MH  - Transsexualism/diagnosis/*psychology
EDAT- 2010/02/23 06:00
MHDA- 2010/09/18 06:00
CRDT- 2010/02/23 06:00
PHST- 2010/02/23 06:00 [entrez]
PHST- 2010/02/23 06:00 [pubmed]
PHST- 2010/09/18 06:00 [medline]
AID - S1529879509100042 [pii]
AID - 10.1353/pbm.0.0138 [doi]
PST - ppublish
SO  - Perspect Biol Med. 2010 Winter;53(1):46-60. doi: 10.1353/pbm.0.0138.


PMID- 20172652
OWN - NLM
STAT- MEDLINE
DCOM- 20100810
LR  - 20220317
IS  - 1872-6623 (Electronic)
IS  - 0304-3959 (Linking)
VI  - 149
IP  - 2
DP  - 2010 May
TI  - Inclusion of authorized deception in the informed consent process does not affect
      the magnitude of the placebo effect for experimentally induced pain.
PG  - 208-215
LID - 10.1016/j.pain.2009.12.004 [doi]
AB  - The ethics of placebo research have been of paramount concern since the discovery
      of the phenomenon. To address these ethical concerns, Miller and colleagues (PLoS
      Med 2005 Sep;2(9):e262, 0853-0859) propose an alternate approach to placebo
      research, called "authorized deception", in which participants are alerted of the
      use of deception in the research prior to study enrollment and thus knowingly
      permit its use if they decide to participate. The present study sought to
      investigate the authorized deception methodology in experimentally induced
      placebo analgesia. The participants were randomly assigned to an authorized
      deception or non-authorized deception group. A commonly used protocol was
      employed wherein heat pain stimulation was surreptitiously lowered following the 
      application of a placebo cream during a series of conditioning trials and the
      magnitude of the placebo effect was subsequently assessed in test trials for
      which the stimulus intensity was the same for both the placebo and control
      creams. Authorized deception did not have any negative impact on the magnitude of
      the placebo effect, recruitment and retention of participants, nor did it result 
      in any significant psychological harm. The majority of participants who received 
      this form of consent preferred it to the traditional approach in which the
      participants are not alerted to the presence of deception. These findings suggest
      that the use of authorized deception is a viable and ethically preferable
      alternative consent process for laboratory-based studies on placebo analgesia.
      Further studies are needed to examine the effect of authorized deception in
      clinical trials and other placebo research within a clinical setting.
CI  - Copyright 2009 International Association for the Study of Pain. Published by
      Elsevier B.V. All rights reserved.
FAU - Martin, Andrea L
AU  - Martin AL
AD  - Department of Psychology, Behavioral Sciences Building, York University, 4700
      Keele Street, Toronto, Ont., Canada M3J 1P3.
FAU - Katz, Joel
AU  - Katz J
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100220
PL  - United States
TA  - Pain
JT  - Pain
JID - 7508686
RN  - 0 (Analgesics)
SB  - IM
MH  - Administration, Topical
MH  - Analgesia/*methods/*psychology
MH  - Analgesics/pharmacology
MH  - Culture
MH  - Deception
MH  - Female
MH  - Hot Temperature/adverse effects
MH  - Humans
MH  - Illusions/psychology
MH  - Informed Consent/*psychology
MH  - Male
MH  - Neuropsychological Tests
MH  - Pain/diagnosis/*psychology
MH  - *Pain Management
MH  - Pain Measurement/methods/psychology
MH  - *Placebo Effect
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2010/02/23 06:00
MHDA- 2010/08/11 06:00
CRDT- 2010/02/23 06:00
PHST- 2009/08/05 00:00 [received]
PHST- 2009/11/09 00:00 [revised]
PHST- 2009/12/02 00:00 [accepted]
PHST- 2010/02/23 06:00 [entrez]
PHST- 2010/02/23 06:00 [pubmed]
PHST- 2010/08/11 06:00 [medline]
AID - 00006396-201005000-00010 [pii]
AID - 10.1016/j.pain.2009.12.004 [doi]
PST - ppublish
SO  - Pain. 2010 May;149(2):208-215. doi: 10.1016/j.pain.2009.12.004. Epub 2010 Feb 20.


PMID- 20172638
OWN - NLM
STAT- MEDLINE
DCOM- 20100608
LR  - 20220317
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 70
IP  - 9
DP  - 2010 May
TI  - Credit where credit is due? Regulation, research integrity and the attribution of
      authorship in the health sciences.
PG  - 1458-65
LID - 10.1016/j.socscimed.2010.01.013 [doi]
AB  - Despite attempts at clear direction in international, national and journal
      guidelines, attribution of authorship can be a confusing area for both new and
      established researchers. As journal articles are valuable intellectual property, 
      authorship can be hotly contested. Individual authors' responsibilities for the
      integrity of article content have not been well explored. Semi-structured
      interviews (n = 17) were conducted with staff, student advocates and doctoral
      candidates working in health research in two universities in Australia.
      Stratified sampling ensured participants reflected a range of experience across
      biomedical, clinical and social science disciplines. Participants were asked
      about their experience with research publication and their views on the
      responsibilities of authorship. Participants gave a variety of reasons for
      attribution of authorship including: writing the paper; seniority; and student
      supervision. Gift authorship was seen by some participants as: a way of
      maintaining relationships; a reward; a means to increase a paper's credibility;
      or a demonstration of collaboration between authors. Norms and beliefs differed
      markedly between disciplines for authorship attribution and, to a lesser extent, 
      for authors' responsibility for content integrity. Discussions about the effect
      of power differentials on authorship were common across disciplines. This paper
      describes a broad range of beliefs, values and practice norms held by health
      science researchers with respect to attribution of authorship and author
      responsibility for scientific publications. The findings support the need for
      clarity in relation to authorship, and a research environment which is supportive
      of ethical behaviour in the publication of research.
CI  - Copyright 2010 Elsevier Ltd. All rights reserved.
FAU - Street, Jackie M
AU  - Street JM
AD  - School of Population Health and Clinical Practice, University of Adelaide,
      Adelaide 5005, Australia. jackie.street@adelaide.edu.au
FAU - Rogers, Wendy A
AU  - Rogers WA
FAU - Israel, Mark
AU  - Israel M
FAU - Braunack-Mayer, Annette J
AU  - Braunack-Mayer AJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100212
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Australia
MH  - *Authorship
MH  - Biomedical Research/*ethics
MH  - Guidelines as Topic
MH  - Humans
MH  - Interviews as Topic
MH  - Publications
MH  - Research Personnel/*ethics
MH  - Universities
EDAT- 2010/02/23 06:00
MHDA- 2010/06/09 06:00
CRDT- 2010/02/23 06:00
PHST- 2009/02/26 00:00 [received]
PHST- 2010/01/05 00:00 [revised]
PHST- 2010/01/06 00:00 [accepted]
PHST- 2010/02/23 06:00 [entrez]
PHST- 2010/02/23 06:00 [pubmed]
PHST- 2010/06/09 06:00 [medline]
AID - S0277-9536(10)00084-5 [pii]
AID - 10.1016/j.socscimed.2010.01.013 [doi]
PST - ppublish
SO  - Soc Sci Med. 2010 May;70(9):1458-65. doi: 10.1016/j.socscimed.2010.01.013. Epub
      2010 Feb 12.


PMID- 20172623
OWN - NLM
STAT- MEDLINE
DCOM- 20100528
LR  - 20100514
IS  - 1097-6787 (Electronic)
IS  - 0190-9622 (Linking)
VI  - 62
IP  - 6
DP  - 2010 Jun
TI  - Drug samples in dermatology: special considerations and recommendations for the
      future.
PG  - 1053-61
LID - 10.1016/j.jaad.2009.07.053 [doi]
AB  - BACKGROUND: The use of drug samples is a controversial issue in medicine.
      OBJECTIVE: We sought to determine the pros and cons of drug sampling, and how
      drug sampling in general medicine differs from dermatology. METHODS: Literature
      searches were conducted on PubMed, Google, and Yahoo!. Articles were found
      pertaining to drug sampling in general, and for dermatology specifically.
      RESULTS: Numerous pros and cons for drug sampling were found in the literature
      search. We divided these by cost-related issues, such as the industry-wide cost
      of sampling and the use of sampling to assist the underinsured and poor, and
      quality of care issues, such as adherence, patient education, and safety
      considerations. Articles also suggested that dermatology may differ from general 
      medicine as topical treatments have fewer side effects, are more complicated to
      use, and come in different vehicles. LIMITATIONS: We identified few studies
      specifically focused on issues relevant to sampling in dermatology. CONCLUSION:
      There are strong arguments for and against drug sampling involving both cost and 
      quality of care issues. Dermatology-specific medications clearly differ from oral
      medications in several regards. We ultimately conclude that the benefits of drug 
      sampling outweigh the risks, but give recommendations on how drug sampling can be
      done ethically and effectively, including limiting personal use, not selling
      samples, properly documenting sample release, teaching patients about proper use,
      teaching students and residents ethical use of samples, working with
      pharmaceutical representatives in an ethical manner, prescribing the drug that is
      best for the patient, and securing samples appropriately to prevent theft and
      misuse.
CI  - Copyright 2010 American Academy of Dermatology, Inc. Published by Mosby, Inc. All
      rights reserved.
FAU - Alikhan, Ali
AU  - Alikhan A
AD  - University of California at Davis, School of Medicine, CA, USA.
      alialikhan1@yahoo.com
FAU - Sockolov, Mary
AU  - Sockolov M
FAU - Brodell, Robert T
AU  - Brodell RT
FAU - Feldman, Steven R
AU  - Feldman SR
LA  - eng
PT  - Editorial
DEP - 20100220
PL  - United States
TA  - J Am Acad Dermatol
JT  - Journal of the American Academy of Dermatology
JID - 7907132
RN  - 0 (Dermatologic Agents)
RN  - 0 (Drugs, Generic)
SB  - IM
CIN - J Am Acad Dermatol. 2010 Jun;62(6):1062-3. PMID: 20172624
MH  - *Dermatologic Agents/economics
MH  - *Dermatology
MH  - *Drug Industry/economics
MH  - Drug Prescriptions
MH  - Drugs, Generic
MH  - Ethics, Business
MH  - Ethics, Medical
MH  - Humans
MH  - *Marketing
EDAT- 2010/02/23 06:00
MHDA- 2010/05/29 06:00
CRDT- 2010/02/23 06:00
PHST- 2009/05/28 00:00 [received]
PHST- 2009/07/03 00:00 [revised]
PHST- 2009/07/09 00:00 [accepted]
PHST- 2010/02/23 06:00 [entrez]
PHST- 2010/02/23 06:00 [pubmed]
PHST- 2010/05/29 06:00 [medline]
AID - S0190-9622(09)01353-X [pii]
AID - 10.1016/j.jaad.2009.07.053 [doi]
PST - ppublish
SO  - J Am Acad Dermatol. 2010 Jun;62(6):1053-61. doi: 10.1016/j.jaad.2009.07.053. Epub
      2010 Feb 20.


PMID- 20172456
OWN - NLM
STAT- MEDLINE
DCOM- 20100610
LR  - 20100222
IS  - 1769-664X (Electronic)
IS  - 0929-693X (Linking)
VI  - 17 Suppl 1
DP  - 2010 Feb
TI  - [Issues related to consent to healthcare decisions in children and adolescents].
PG  - S7-15
LID - 10.1016/S0929-693X(10)70003-8 [doi]
AB  - The process of consent to healthcare decisions in children and adolescents often 
      set physicians difficult problems. From what age is a child able to understand
      the information given to him or her about illness and treatment? Is an ill child 
      indeed in the capacity to give his or her voluntary consent to treatment? How to 
      define and to assess the capacity of an ill child to take part in treatment
      decisions? More than the age of the child, it is his or her level of cognitive,
      emotional and social development and its interactions with illness that will
      determine his or her degree of involvement in the decision-making process. There 
      is a moral and ethical need to respect the rights and autonomy of every
      individual, regardless of age. This does not mean viewing children and
      adolescents as rational and autonomous decision-makers. This implies that we must
      promote their developmentally appropriate participation in shared decision-making
      with parents and physicians. Therefore, instead of asking, "should children and
      adolescents be granted absolute autonomy in decision making?" we ought to ask,
      "should we treat children and adolescents like people?"
CI  - Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
FAU - Bailly, D
AU  - Bailly D
AD  - Service hospitalo-universitaire de psychiatrie, Hopital Sainte-Marguerite, 270
      boulevard de Sainte Marguerite, Marseille, France. daniel.bailly@ap-hm.fr
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Problemes lies au consentement chez l'enfant et l'adolescent.
PL  - France
TA  - Arch Pediatr
JT  - Archives de pediatrie : organe officiel de la Societe francaise de pediatrie
JID - 9421356
SB  - IM
MH  - Adolescent
MH  - Biomedical Research/ethics
MH  - Child
MH  - Decision Making/*ethics
MH  - Humans
MH  - *Informed Consent
MH  - Mental Competency
MH  - *Minors
MH  - Physician-Patient Relations
EDAT- 2010/02/23 06:00
MHDA- 2010/06/11 06:00
CRDT- 2010/02/23 06:00
PHST- 2010/02/23 06:00 [entrez]
PHST- 2010/02/23 06:00 [pubmed]
PHST- 2010/06/11 06:00 [medline]
AID - S0929-693X(10)70003-8 [pii]
AID - 10.1016/S0929-693X(10)70003-8 [doi]
PST - ppublish
SO  - Arch Pediatr. 2010 Feb;17 Suppl 1:S7-15. doi: 10.1016/S0929-693X(10)70003-8.


PMID- 20172455
OWN - NLM
STAT- MEDLINE
DCOM- 20100610
LR  - 20100222
IS  - 1769-664X (Electronic)
IS  - 0929-693X (Linking)
VI  - 17 Suppl 1
DP  - 2010 Feb
TI  - [Justice and equity as determinants of medical decision-making].
PG  - S32-8
LID - 10.1016/S0929-693X(10)70006-3 [doi]
AB  - Every medical decision-making is to do justice to the one who suffers and who
      considers his pain as nonsensical. This requirement falls into 3 universal
      ethical principles, governing the patient-doctor relationship: the autonomy of
      the person even if it is a young child, beneficence and non-maleficence. Adhering
      to these principles gives medical decision-making its ethical dimension. It
      implies that the doctor makes the best use of the emotions that he feels in front
      of his patient and/or in front of his relatives: respect for autonomy, the
      beneficent compassion and the fear of maleficence in diagnosis and care. If a
      paediatrician combines these 3 affects harmoniously, his attitude is in keeping
      with the requirement of justice, which is the quintessence of Ethics. However,
      reality is often more complex, a source of conflicting emotions and, in fine, a
      source of an anguish whose benefit is yet to alert on the necessity to carry on
      looking for the right decision-making: the emotional revision consists of a
      meta-analysis of the objective and subjective data of the problem. It preciously 
      helps to establish a compromise of justice. Eventually, in order to be just, the 
      doctor must include the concern of equity amongst the criteria of his
      decision-making, in other words a fair allocation of the goods and of the care
      services. Unfortunately, this concern is undermined by geopolitical,
      socio-economic and cultural factors, which vary greatly according to the
      environmental conditions that might mar what should be optimal ethical
      decisionmaking. The doctor cannot solve these problems on his own, but he has to 
      know them in order to deal with them.
CI  - Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
FAU - Le Coz, P
AU  - Le Coz P
AD  - Faculte de Medecine de Marseille (EA 3783), 27 boulevard Jean Moulin, Marseille
      cedex 5, France. pierre.lecoz@ap-hm.fr
FAU - Kachaner, J
AU  - Kachaner J
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Justice et equite dans la decision medicale.
PL  - France
TA  - Arch Pediatr
JT  - Archives de pediatrie : organe officiel de la Societe francaise de pediatrie
JID - 9421356
SB  - IM
MH  - Culture
MH  - Decision Making/*ethics
MH  - Emotions
MH  - Humans
MH  - Personal Autonomy
MH  - Physicians/*psychology
MH  - Socioeconomic Factors
EDAT- 2010/02/23 06:00
MHDA- 2010/06/11 06:00
CRDT- 2010/02/23 06:00
PHST- 2010/02/23 06:00 [entrez]
PHST- 2010/02/23 06:00 [pubmed]
PHST- 2010/06/11 06:00 [medline]
AID - S0929-693X(10)70006-3 [pii]
AID - 10.1016/S0929-693X(10)70006-3 [doi]
PST - ppublish
SO  - Arch Pediatr. 2010 Feb;17 Suppl 1:S32-8. doi: 10.1016/S0929-693X(10)70006-3.


PMID- 20172364
OWN - NLM
STAT- MEDLINE
DCOM- 20100317
LR  - 20191210
IS  - 1532-8708 (Electronic)
IS  - 0093-7754 (Linking)
VI  - 37
IP  - 1
DP  - 2010 Feb
TI  - Tailored cancer outcome prediction and informed consent.
PG  - 47-52
LID - 10.1053/j.seminoncol.2009.12.008 [doi]
AB  - Clinically relevant disparities in the outcomes of cancer treatment between
      institutions are well established. Some authors have argued that physicians have 
      an ethical obligation to disclose these disparities as part of the informed
      consent process.(1) We believe that preservation of patient autonomy requires
      disclosure of treatment institution-specific outcomes and that statistical
      prediction models tailored to individual patients are the best way to frame this 
      discussion. We describe a utopian system to gather and disseminate cancer outcome
      data based on the United Network for Organ Sharing and articulate why accurate
      and equitable prediction models are feasible both scientifically and
      logistically. We also discuss strategies of design and oversight required to
      mitigate any unintended negative downstream consequences of such a system.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Patrick, Robert
AU  - Patrick R
AD  - Department of Hospital Medicine, Cleveland Clinic Foundation, Cleveland, OH
      44195,USA. patricr2@ccf.org
FAU - Buccini, Laura
AU  - Buccini L
FAU - Kattan, Michael W
AU  - Kattan MW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Semin Oncol
JT  - Seminars in oncology
JID - 0420432
SB  - IM
MH  - Comorbidity
MH  - Decision Making
MH  - Humans
MH  - *Informed Consent
MH  - Models, Statistical
MH  - Neoplasms/mortality/*therapy
MH  - *Outcome Assessment, Health Care
MH  - Personal Autonomy
MH  - Truth Disclosure
EDAT- 2010/02/23 06:00
MHDA- 2010/03/18 06:00
CRDT- 2010/02/23 06:00
PHST- 2010/02/23 06:00 [entrez]
PHST- 2010/02/23 06:00 [pubmed]
PHST- 2010/03/18 06:00 [medline]
AID - S0093-7754(09)00233-4 [pii]
AID - 10.1053/j.seminoncol.2009.12.008 [doi]
PST - ppublish
SO  - Semin Oncol. 2010 Feb;37(1):47-52. doi: 10.1053/j.seminoncol.2009.12.008.


PMID- 20172301
OWN - NLM
STAT- MEDLINE
DCOM- 20100603
LR  - 20100222
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 42
IP  - 1
DP  - 2010 Jan-Feb
TI  - Presumed consent for organ donation: is Romania prepared for it?
PG  - 144-6
LID - 10.1016/j.transproceed.2009.12.006 [doi]
AB  - INTRODUCTION: In November 2007, a legislative initiative regarding the presumed
      consent for organ donation was proposed for parliamentary debate in Romania and
      was followed by public debate. The study aimed to asses public opinions expressed
      in the Romanian media. MATERIALS AND METHODS: An Internet search was made. The
      pro and con reasons, the affiliation of parts involved in the debate and
      suggested future direction of action were identified. RESULTS: The Internet
      search had 8572 results. The parts involved in the pro and con debate consisted
      of governmental structures, physicians, ethicists, politicians, media, religious 
      authorities, nongovernmental associations, and lay persons. The main pros were
      the low rate of organ donation and the long waiting lists, enhancement of organ
      procurement, avoidance of wasting valuable organs, avoiding responsibility, and
      the stress imposed to the family in giving the donation consent, humanitarian
      purposes (saving lives), going along with the scientific progress, and less
      bureaucracy. The main cons were an unethical issue, violation of human rights,
      denial of brain death, unethical advantage of public ignorance, unethical use of 
      underprivileged people, little results in terms of organ procurement, but huge
      negative effects on public opinion, public mistrust in transplant programs and
      impossibility of refusal identification due to particularities of the Romanian
      medical system. CONCLUSION: The con opinions prevailed. For the moment, Romania
      seems to be unprepared to accept presumed consent. A future change in public
      perception regarding organ transplantation may modify the terms of a public
      debate.
FAU - Grigoras, I
AU  - Grigoras I
AD  - University of Medicine and Pharmacy, Iasi, Romania. grigorasioana@yahoo.com
FAU - Condac, C
AU  - Condac C
FAU - Cartes, C
AU  - Cartes C
FAU - Blaj, M
AU  - Blaj M
FAU - Florin, G
AU  - Florin G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - Altruism
MH  - Ethics, Medical
MH  - Humans
MH  - Internet
MH  - Legislation, Medical
MH  - Mass Media
MH  - Organizations
MH  - Perception
MH  - Politics
MH  - Presumed Consent/*legislation & jurisprudence
MH  - Romania
MH  - Tissue and Organ Procurement/*legislation & jurisprudence
EDAT- 2010/02/23 06:00
MHDA- 2010/06/04 06:00
CRDT- 2010/02/23 06:00
PHST- 2010/02/23 06:00 [entrez]
PHST- 2010/02/23 06:00 [pubmed]
PHST- 2010/06/04 06:00 [medline]
AID - S0041-1345(09)01760-6 [pii]
AID - 10.1016/j.transproceed.2009.12.006 [doi]
PST - ppublish
SO  - Transplant Proc. 2010 Jan-Feb;42(1):144-6. doi:
      10.1016/j.transproceed.2009.12.006.


PMID- 20172295
OWN - NLM
STAT- MEDLINE
DCOM- 20100603
LR  - 20100222
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 42
IP  - 1
DP  - 2010 Jan-Feb
TI  - Donor compensation: an ethical imperative!
PG  - 124-5
LID - 10.1016/j.transproceed.2009.12.041 [doi]
AB  - The number of living organ donors is increasing worldwide, but donor needs are
      widely neglected in support of anticommodification policies. This article argues 
      that the warrant of donor autonomy during the decision process to donate is only 
      one requirement of adequate donor care. Another is the donor's protection against
      the systematic and institutional exploitation of his altruistic dispositions.
      People with the disposition to support those, who are in desperate need, with a
      nonrenewable part of their own body, despite a small but unavoidable risk of
      death or health impairment, do not deserve to be additionally burdened with
      further disincentives, such as financial risks and uncompensated costs of
      donation. And although the borderline between a morally required disincentive
      removal and a more controversial net incentive to boost donation might be vague
      and open to discussion, to disadvantage living donors by design constitutes a
      serious barrier to the fairness of living organ donation-a barrier that should be
      removed.
FAU - Reichardt, J-O
AU  - Reichardt JO
AD  - Translational Centre for Regenerative Medicine, the University of Leipzig,
      Leipzig, Germany. joreichardt@trm.uni-leipzig.de
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - Cadaver
MH  - Compensation and Redress/*ethics/legislation & jurisprudence
MH  - Germany
MH  - Hepatectomy/economics/ethics
MH  - Humans
MH  - Iran
MH  - Kidney
MH  - Liver
MH  - Living Donors/statistics & numerical data
MH  - Nephrectomy/economics/ethics
MH  - Tissue and Organ Procurement/*economics/*statistics & numerical data
MH  - United States
MH  - Waiting Lists
EDAT- 2010/02/23 06:00
MHDA- 2010/06/04 06:00
CRDT- 2010/02/23 06:00
PHST- 2010/02/23 06:00 [entrez]
PHST- 2010/02/23 06:00 [pubmed]
PHST- 2010/06/04 06:00 [medline]
AID - S0041-1345(09)01797-7 [pii]
AID - 10.1016/j.transproceed.2009.12.041 [doi]
PST - ppublish
SO  - Transplant Proc. 2010 Jan-Feb;42(1):124-5. doi:
      10.1016/j.transproceed.2009.12.041.


PMID- 20171601
OWN - NLM
STAT- MEDLINE
DCOM- 20100903
LR  - 20161125
IS  - 1097-6868 (Electronic)
IS  - 0002-9378 (Linking)
VI  - 203
IP  - 1
DP  - 2010 Jul
TI  - Twin-twin transfusion syndrome: an ethics-based and evidence-based argument for
      clinical research.
PG  - 3-16
LID - 10.1016/j.ajog.2009.12.006 [doi]
AB  - Aspects of twin-twin transfusion syndrome (TTTS) diagnosis, treatment
      alternatives, and research opportunities were considered during a consensus
      conference that was held by the North American Fetal Therapy Network in 2009. A
      3-member scientific consensus panel gathered data from expert conference
      presentations, postconference communications, and comprehensive scientific
      literature database searches to develop recommendations for TTTS diagnosis,
      therapy, and research. The panel recommends retaining the Quintero staging system
      until a superior system has been validated appropriately. It concludes that there
      is normative equipoise to justify the performance of randomized clinical trials
      to identify the optimal treatment strategy for mild TTTS. Recommendations for the
      design and conduct of clinical trials and observational studies are also
      provided.
CI  - Copyright (c) 2010 Mosby, Inc. All rights reserved.
FAU - Stamilio, David M
AU  - Stamilio DM
AD  - Department of Obstetrics & Gynecology, Maternal Fetal Medicine Division,
      Washington University School of Medicine, St. Louis, MO, USA.
FAU - Fraser, William D
AU  - Fraser WD
FAU - Moore, Thomas R
AU  - Moore TR
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100220
PL  - United States
TA  - Am J Obstet Gynecol
JT  - American journal of obstetrics and gynecology
JID - 0370476
SB  - IM
CIN - Am J Obstet Gynecol. 2010 Jul;203(1):1-2. PMID: 20609700
MH  - Female
MH  - Fetofetal Transfusion/diagnostic imaging/*physiopathology/surgery
MH  - Humans
MH  - Laser Coagulation
MH  - Pregnancy
MH  - *Pregnancy, Multiple
MH  - *Twins, Monozygotic
MH  - Ultrasonography, Prenatal
RF  - 81
EDAT- 2010/02/23 06:00
MHDA- 2010/09/04 06:00
CRDT- 2010/02/23 06:00
PHST- 2009/08/28 00:00 [received]
PHST- 2009/11/29 00:00 [revised]
PHST- 2009/12/07 00:00 [accepted]
PHST- 2010/02/23 06:00 [entrez]
PHST- 2010/02/23 06:00 [pubmed]
PHST- 2010/09/04 06:00 [medline]
AID - S0002-9378(09)02249-2 [pii]
AID - 10.1016/j.ajog.2009.12.006 [doi]
PST - ppublish
SO  - Am J Obstet Gynecol. 2010 Jul;203(1):3-16. doi: 10.1016/j.ajog.2009.12.006. Epub 
      2010 Feb 20.


PMID- 20171546
OWN - NLM
STAT- MEDLINE
DCOM- 20100505
LR  - 20100222
IS  - 1557-9824 (Electronic)
IS  - 0891-5520 (Linking)
VI  - 24
IP  - 1
DP  - 2010 Mar
TI  - Chlamydophila pneumoniae.
PG  - 61-71
LID - 10.1016/j.idc.2009.10.002 [doi]
AB  - Chlamydophila pneumoniae is estimated to cause about 10% of community-acquired
      pneumonia (CAP) cases and 5% of bronchitis cases, although most patients with C
      pneumoniae infection are asymptomatic, and the course of respiratory illness is
      relatively mild. The incubation period of C pneumoniae infection is around 21
      days, and such symptoms as cough and malaise show a gradual onset, yet may
      persist for several weeks or months despite appropriate antibiotic therapy.
      Diagnosis by nasopharyngeal specimen culture, serum antibody titers, or molecular
      techniques is usually delayed with respect to the onset of symptoms, antibiotic
      treatment, or disease resolution and there is no accurate, standardized,
      commercial US Food and Drug Administration-cleared diagnostic method available.
      Erythromycin, tetracycline, and doxycycline are used as first-line therapy,
      although some investigators report no clinical or survival benefits from treating
      CAP caused by atypical pathogens. Meanwhile, adequate prospective studies have
      met with ethical and logistic barriers. Despite these limitations, North American
      guidelines recommend the antimicrobial treatment of patients with acute C
      pneumoniae respiratory infection.
CI  - Copyright 2010. Published by Elsevier Inc.
FAU - Burillo, Almudena
AU  - Burillo A
AD  - Clinical Microbiology Department, Hospital Universitario de Mostoles, C/Rio
      Jucar, s/n, 28935 Mostoles, Madrid, Spain.
FAU - Bouza, Emilio
AU  - Bouza E
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Infect Dis Clin North Am
JT  - Infectious disease clinics of North America
JID - 8804508
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Antibodies, Bacterial)
SB  - IM
MH  - Anti-Bacterial Agents/therapeutic use
MH  - Antibodies, Bacterial/blood
MH  - Chlamydophila Infections/*diagnosis/epidemiology/microbiology/*therapy
MH  - Chlamydophila pneumoniae/*isolation & purification
MH  - Community-Acquired Infections/*epidemiology/*etiology
MH  - Guidelines as Topic
MH  - Humans
MH  - Molecular Diagnostic Techniques/methods
MH  - Nasopharynx/microbiology
MH  - Pneumonia, Bacterial/*diagnosis/epidemiology/microbiology/*therapy
MH  - United States
RF  - 67
EDAT- 2010/02/23 06:00
MHDA- 2010/05/06 06:00
CRDT- 2010/02/23 06:00
PHST- 2010/02/23 06:00 [entrez]
PHST- 2010/02/23 06:00 [pubmed]
PHST- 2010/05/06 06:00 [medline]
AID - S0891-5520(09)00074-9 [pii]
AID - 10.1016/j.idc.2009.10.002 [doi]
PST - ppublish
SO  - Infect Dis Clin North Am. 2010 Mar;24(1):61-71. doi: 10.1016/j.idc.2009.10.002.


PMID- 20171404
OWN - NLM
STAT- MEDLINE
DCOM- 20100311
LR  - 20220331
IS  - 1474-547X (Electronic)
IS  - 0140-6736 (Linking)
VI  - 375
IP  - 9715
DP  - 2010 Feb 20
TI  - Biological, clinical, and ethical advances of placebo effects.
PG  - 686-95
LID - 10.1016/S0140-6736(09)61706-2 [doi]
AB  - For many years, placebos have been defined by their inert content and their use
      as controls in clinical trials and treatments in clinical practice. Recent
      research shows that placebo effects are genuine psychobiological events
      attributable to the overall therapeutic context, and that these effects can be
      robust in both laboratory and clinical settings. There is also evidence that
      placebo effects can exist in clinical practice, even if no placebo is given.
      Further promotion and integration of laboratory and clinical research will allow 
      advances in the ethical use of placebo mechanisms that are inherent in routine
      clinical care, and encourage the use of treatments that stimulate placebo
      effects.
CI  - Copyright 2010 Elsevier Ltd. All rights reserved.
FAU - Finniss, Damien G
AU  - Finniss DG
AD  - University of Sydney Pain Management and Research Institute, Royal North Shore
      Hospital, St Leonards, NSW, Australia. dfinniss@med.usyd.edu.au
FAU - Kaptchuk, Ted J
AU  - Kaptchuk TJ
FAU - Miller, Franklin
AU  - Miller F
FAU - Benedetti, Fabrizio
AU  - Benedetti F
LA  - eng
GR  - K24 AT004095/AT/NCCIH NIH HHS/United States
GR  - K24 AT004095-03/AT/NCCIH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Lancet
JT  - Lancet (London, England)
JID - 2985213R
RN  - 0 (Placebos)
SB  - IM
CIN - Eur Urol. 2010 Nov;58(5):792-3. PMID: 21414856
MH  - Clinical Trials as Topic/*ethics
MH  - Ethics, Medical
MH  - Ethics, Research
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Physician-Patient Relations/ethics
MH  - *Placebo Effect
MH  - Placebos/*pharmacology
MH  - Practice Patterns, Physicians'/ethics
MH  - Research Subjects
MH  - Treatment Outcome
RF  - 107
PMC - PMC2832199
MID - NIHMS169379
EDAT- 2010/02/23 06:00
MHDA- 2010/03/12 06:00
CRDT- 2010/02/23 06:00
PHST- 2010/02/23 06:00 [entrez]
PHST- 2010/02/23 06:00 [pubmed]
PHST- 2010/03/12 06:00 [medline]
AID - S0140-6736(09)61706-2 [pii]
AID - 10.1016/S0140-6736(09)61706-2 [doi]
PST - ppublish
SO  - Lancet. 2010 Feb 20;375(9715):686-95. doi: 10.1016/S0140-6736(09)61706-2.


PMID- 20170558
OWN - NLM
STAT- MEDLINE
DCOM- 20100322
LR  - 20181201
IS  - 1876-8784 (Electronic)
IS  - 0028-2162 (Linking)
VI  - 154
DP  - 2010
TI  - [Crisis in human resources for health: millennium development goals for maternal 
      and child health threatened].
PG  - A1159
AB  - International migration of health care workers from low-income countries to the
      West has increased considerably in recent years, thereby jeopardizing the
      achievements of The Millennium Development Goals, especially number 4 (reduction 
      of child mortality) and 5 (improvement of maternal health).This migration, as
      well as the HIV/AIDS epidemic, lack of training of health care personnel and
      poverty, are mainly responsible for this health care personnel deficit. It is
      essential that awareness be raised amongst donors and local governments so that
      staffing increases, and that infection prevention measures be in place for their 
      health care personnel. Western countries should conduct a more ethical
      recruitment of health care workers, otherwise a new millennium development goal
      will have to be created: to reduce the human resources for health crisis.
FAU - Beltman, Jogchum J
AU  - Beltman JJ
AD  - Leids Universitair Medisch Centrum, afd. Verloskunde, The Netherlands.
      jbeltman@tiscali.nl
FAU - Stekelenburg, Jelle
AU  - Stekelenburg J
FAU - van Roosmalen, Jos
AU  - van Roosmalen J
LA  - dut
PT  - Journal Article
TT  - Tekort aan gezondheidswerkers in Afrika: millenniumdoelstellingen voor moeder- en
      kindzorg in gevaar.
PL  - Netherlands
TA  - Ned Tijdschr Geneeskd
JT  - Nederlands tijdschrift voor geneeskunde
JID - 0400770
SB  - IM
MH  - Adult
MH  - Child
MH  - *Child Health Services
MH  - Child Mortality/*trends
MH  - Child, Preschool
MH  - Emigration and Immigration
MH  - Female
MH  - Global Health
MH  - HIV Infections/epidemiology/mortality
MH  - Health Policy/trends
MH  - Health Workforce/statistics & numerical data/*trends
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - International Cooperation
MH  - Male
MH  - *Maternal Health Services
MH  - Maternal Mortality/*trends
MH  - Poverty
MH  - Pregnancy
MH  - United Nations
EDAT- 2010/02/23 06:00
MHDA- 2010/03/23 06:00
CRDT- 2010/02/23 06:00
PHST- 2010/02/23 06:00 [entrez]
PHST- 2010/02/23 06:00 [pubmed]
PHST- 2010/03/23 06:00 [medline]
PST - ppublish
SO  - Ned Tijdschr Geneeskd. 2010;154:A1159.


PMID- 20169955
OWN - NLM
STAT- MEDLINE
DCOM- 20100420
LR  - 20181201
IS  - 0021-4892 (Print)
IS  - 0021-4892 (Linking)
VI  - 59
IP  - 2
DP  - 2010 Feb
TI  - [Effect of remifentanil on intraoperative ECoG--a comparison with sevoflurane].
PG  - 188-92
AB  - BACKGROUND: In surgeries for epilepsy, electrocorticography (ECoG) enables
      tailored resection of the epileptogenic brain and pharmacological stimulation
      should be employed in surgeries under general anesthesia. To identify the
      efficacy of continuous remifentanil in surgeries for epilepsy, ECoG findings with
      remifentanil and those with sevoflurane were compared. METHODS: Sixteen patients 
      with intractable epilepsy were included with institutional ethics committee
      approval and informed consent. General anesthesia was induced and maintained with
      sevoflurane, remifentanil and rocuronium. After dural opening, ECoG recordings
      were obtained before stimulation, with sevoflurane-stimulation (ET-sevoflurane
      2.5%) and with remifentanil-stimulation (0.7 microg x kg(-1) x min(-1) for 2 min 
      followed by 0.35 microg x kg(-1) x min(-1)). RESULTS: In 11 of the 16 cases,
      activation was confirmed with remifentanil and numbers of spikes with
      remifentanil- and sevoflurane-stimulation were larger than those before
      stimulation. CONCLUSIONS: There have been some reports on bolus remifentanil on
      ECoG but not on its continuous infusion. This is the first report of the effect
      of remifentanil on ECoG as compared to sevoflurane. In this study, continuous
      infusion of remifentanil showed a stimulating effect on ECoG with the same
      potency as sevoflurane. Remifentanil may be used as an alternative to
      sevoflurane.
FAU - Sato, Kiyotaka
AU  - Sato K
AD  - Department of Neuroanesthesia, Kohnan Hospital, Sendai 982-8523.
FAU - Iwasaki, Masaki
AU  - Iwasaki M
FAU - Kato, Masato
AU  - Kato M
LA  - jpn
PT  - Comparative Study
PT  - Journal Article
PL  - Japan
TA  - Masui
JT  - Masui. The Japanese journal of anesthesiology
JID - 0413707
RN  - 0 (Anesthetics, Inhalation)
RN  - 0 (Anesthetics, Intravenous)
RN  - 0 (Methyl Ethers)
RN  - 0 (Piperidines)
RN  - 38LVP0K73A (Sevoflurane)
RN  - P10582JYYK (Remifentanil)
SB  - IM
MH  - Administration, Inhalation
MH  - *Anesthesia, General
MH  - Anesthetics, Inhalation/administration & dosage/*pharmacology
MH  - Anesthetics, Intravenous/administration & dosage/*pharmacology
MH  - Cerebral Cortex/*physiopathology
MH  - Electroencephalography/*drug effects
MH  - Epilepsy/physiopathology/*surgery
MH  - Female
MH  - Humans
MH  - Infusions, Intravenous
MH  - Intraoperative Period
MH  - Male
MH  - Methyl Ethers/administration & dosage/*pharmacology
MH  - Piperidines/administration & dosage/*pharmacology
MH  - Remifentanil
MH  - Sevoflurane
MH  - Stimulation, Chemical
EDAT- 2010/02/23 06:00
MHDA- 2010/04/21 06:00
CRDT- 2010/02/23 06:00
PHST- 2010/02/23 06:00 [entrez]
PHST- 2010/02/23 06:00 [pubmed]
PHST- 2010/04/21 06:00 [medline]
PST - ppublish
SO  - Masui. 2010 Feb;59(2):188-92.


PMID- 20169776
OWN - NLM
STAT- MEDLINE
DCOM- 20100311
LR  - 20190902
IS  - 0317-1671 (Print)
IS  - 0317-1671 (Linking)
VI  - 37
IP  - 1
DP  - 2010 Jan
TI  - Diagnosis disclosure of prodromal Alzheimer disease-ethical analysis of two
      cases.
PG  - 67-75
AB  - BACKGROUND: According to a recent proposal for revised diagnostic criteria for
      Alzheimer disease, the diagnosis could be made even in the absence of impairment 
      of social function or daily life activities, provided positivity of one or more
      abnormal biomarkers. The use of the new proposed diagnostic criteria raises
      ethical issues and needs to be carefully evaluated. METHOD: We describe two
      clinical cases of prodromal Alzheimer's disease and discuss the diagnosis
      disclosure, taking into consideration several issues: (i) the issue of the
      boundary between well founded research procedures and clinical practice, (ii) the
      issue of the fuzziness of the concepts of scientific evidence and scientific
      uncertainty, (iii) the issue of patient's autonomy and patient's best interest,
      and (iv) the issue of the patients' specific personal and social context.
      RESULTS: The degree of informativeness of the proposed diagnostic criteria for
      the single patient is already such as to deserve high regard in making the
      diagnosis and in the diagnosis disclosure process. During the disclosure process,
      the physician needs to take into account both what is known and what it is not
      sufficiently known. The patient's personal and environmental conditions should
      drive the physician to partial or full diagnostic disclosure, or delay
      communication. CONCLUSION: We proposed two different diagnosis disclosure
      processes, on the basis of the common neurological features and of the different 
      global clinical situations, socio-personal contexts and attitudes towards the
      communication of the diagnosis.
FAU - Porteri, Corinna
AU  - Porteri C
AD  - Bioethics Unit, IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia,
      Italy.
FAU - Galluzzi, Samantha
AU  - Galluzzi S
FAU - Geroldi, Cristina
AU  - Geroldi C
FAU - Frisoni, Giovanni B
AU  - Frisoni GB
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Can J Neurol Sci
JT  - The Canadian journal of neurological sciences. Le journal canadien des sciences
      neurologiques
JID - 0415227
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Peptide Fragments)
RN  - 0 (amyloid beta-protein (1-42))
SB  - IM
CIN - Can J Neurol Sci. 2010 Jan;37(1):2. PMID: 20169766
MH  - Aged
MH  - Alzheimer Disease/cerebrospinal fluid/*diagnosis/*psychology
MH  - Amyloid beta-Peptides/cerebrospinal fluid
MH  - *Ethical Analysis
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Neuropsychological Tests
MH  - Peptide Fragments/cerebrospinal fluid
MH  - Physician-Patient Relations/*ethics
MH  - Positron-Emission Tomography
MH  - Social Behavior
MH  - *Truth Disclosure
EDAT- 2010/02/23 06:00
MHDA- 2010/03/12 06:00
CRDT- 2010/02/23 06:00
PHST- 2010/02/23 06:00 [entrez]
PHST- 2010/02/23 06:00 [pubmed]
PHST- 2010/03/12 06:00 [medline]
AID - 10.1017/s0317167100009677 [doi]
PST - ppublish
SO  - Can J Neurol Sci. 2010 Jan;37(1):67-75. doi: 10.1017/s0317167100009677.


PMID- 20169422
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20211020
IS  - 1970-9366 (Electronic)
IS  - 1828-0447 (Linking)
VI  - 5
IP  - 3
DP  - 2010 Jun
TI  - The uncontrolled clinical trial: scientific, ethical, and practical reasons for
      being.
PG  - 201-4
LID - 10.1007/s11739-010-0355-z [doi]
AB  - According to principles of clinical trial design, the demonstration of efficacy
      of a new treatment is based on comparing the response in the treated group with
      that of a control group receiving placebo or another active treatment. The need
      for a control group is also recommended by the major international institutions
      that govern the ethics and the practice of clinical research. Despite these
      principles and recommendations, inspection of a purposive sample of ongoing
      clinical trials listed in the NIH registry ( http://ClinicalTrials.gov ) reveals 
      that as many as one-third of trials are uncontrolled. Since these trials were
      approved through a formal evaluation by ethics committees, the lack of adequate
      control was not perceived as a major deficiency in the study design. Most
      uncontrolled trials belong to the oncology/hematology area. If two extreme
      disease conditions for nature and progression are analyzed, such as acute myeloid
      leukemia (AML) and chronic heart failure (CHF), the difference in the prevalence 
      of uncontrolled trials is very striking. The number of uncontrolled trials is
      only 13% in CHF, whereas it reaches 66% in the AML group. I believe that the
      underlying disease condition plays a primary role in orienting the design of the 
      study: oncology and hematology may be fields in which uncontrolled studies are
      common, whereas in other fields, e.g., cardiology, this phenomenon can be
      reduced. Within the limitations of the selection process of the examined trials, 
      the current analysis indicates that the clinical trial reality does not strictly 
      follow experimental design theory and official recommendations.
FAU - Sacca, Luigi
AU  - Sacca L
AD  - Department of Internal Medicine and Cardiovascular Sciences, University Federico 
      II, Via Pansini 5, Naples, Italy. sacca@unina.it
LA  - eng
PT  - Journal Article
DEP - 20100219
PL  - Italy
TA  - Intern Emerg Med
JT  - Internal and emergency medicine
JID - 101263418
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Antineoplastic Agents/therapeutic use
MH  - Cardiology
MH  - Clinical Trials, Phase II as Topic/ethics/*standards
MH  - Clinical Trials, Phase III as Topic/ethics/*standards
MH  - *Ethics, Research
MH  - Heart Failure/drug therapy
MH  - Humans
MH  - Leukemia, Myeloid, Acute/drug therapy
MH  - Medical Oncology
EDAT- 2010/02/20 06:00
MHDA- 2010/09/15 06:00
CRDT- 2010/02/20 06:00
PHST- 2009/08/24 00:00 [received]
PHST- 2010/01/13 00:00 [accepted]
PHST- 2010/02/20 06:00 [entrez]
PHST- 2010/02/20 06:00 [pubmed]
PHST- 2010/09/15 06:00 [medline]
AID - 10.1007/s11739-010-0355-z [doi]
PST - ppublish
SO  - Intern Emerg Med. 2010 Jun;5(3):201-4. doi: 10.1007/s11739-010-0355-z. Epub 2010 
      Feb 19.


PMID- 20169420
OWN - NLM
STAT- MEDLINE
DCOM- 20110331
LR  - 20211020
IS  - 1970-9366 (Electronic)
IS  - 1828-0447 (Linking)
VI  - 5
IP  - 2
DP  - 2010 Apr
TI  - Triage in public health emergencies: ethical issues.
PG  - 137-44
LID - 10.1007/s11739-010-0362-0 [doi]
AB  - General concepts about medical disasters, public health and triage are outlined. 
      Triage is described in the context of public health emergencies and disaster
      settings, and the main ethical values at stake in triage are discussed. Possible 
      conflicts between competing values are outlined. Special attention is given to
      possible conflicts between the protection of individual interests (typical of
      clinical ethics), and the pursuit of collective interests (typical of public
      health and triage). Hippocratic ethics is compared to utilitarian ethics and to
      perspectives that emphasize the principle of justice. Three ethical attitudes are
      suggested that may contribute to a resolution of competing values: protection of 
      human dignity, precaution and, especially, solidarity. Personalism promotes the
      collective good by safeguarding and giving value to the well-being of each
      individual. A personalistic perspective is suggested as a way to deepen the
      concept of solidarity as a pillar both of clinical and public health ethics.
FAU - Petrini, Carlo
AU  - Petrini C
AD  - Istituto Superiore di Sanita (National Institute of Health), Bioethics Unit,
      Office of the President, Via Giano della Bella 34, 00162, Rome, Italy.
      carlo.petrini@iss.it
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100219
PL  - Italy
TA  - Intern Emerg Med
JT  - Internal and emergency medicine
JID - 101263418
SB  - IM
MH  - Decision Making/ethics
MH  - Delivery of Health Care/ethics
MH  - Disasters
MH  - *Ethics, Medical
MH  - Humans
MH  - Public Health/*ethics
MH  - Public Health Practice/ethics
MH  - Social Values
MH  - Triage/*ethics
EDAT- 2010/02/20 06:00
MHDA- 2011/04/01 06:00
CRDT- 2010/02/20 06:00
PHST- 2009/11/30 00:00 [received]
PHST- 2010/01/21 00:00 [accepted]
PHST- 2010/02/20 06:00 [entrez]
PHST- 2010/02/20 06:00 [pubmed]
PHST- 2011/04/01 06:00 [medline]
AID - 10.1007/s11739-010-0362-0 [doi]
PST - ppublish
SO  - Intern Emerg Med. 2010 Apr;5(2):137-44. doi: 10.1007/s11739-010-0362-0. Epub 2010
      Feb 19.


PMID- 20168332
OWN - NLM
STAT- MEDLINE
DCOM- 20101026
LR  - 20220408
IS  - 1476-5403 (Electronic)
IS  - 1350-9047 (Linking)
VI  - 17
IP  - 8
DP  - 2010 Aug
TI  - Cell reprogramming: expectations and challenges for chemistry in stem cell
      biology and regenerative medicine.
PG  - 1230-7
LID - 10.1038/cdd.2010.14 [doi]
AB  - The possibility of reprogramming adult somatic cells into pluripotent stem cells 
      (iPSCs) has generated a renewed interest into stem cell research and promises to 
      overcome several key issues, including the ethical concerns of using human
      embryonic stem cells and the difficulty of obtaining large numbers of adult stem 
      cells (Belmonte et al., Nat Rev Genet, 2009). This approach is also not free from
      challenges like the mechanism of the reprogramming process, which has yet to be
      elucidated, and the warranties for safety of generated pluripotent cells,
      especially in view of their possible therapeutic use. Very recently, several new 
      reprogramming methods have surfaced, which seem to be more appropriate than
      genetic reprogramming. Particularly, chemically induced pluripotent cells
      (CiPSs), obtained with recombinant proteins or small synthetic molecules, may
      represent a valid approach, simpler and possibly safer than the other ones.
FAU - Anastasia, L
AU  - Anastasia L
AD  - Department of Medical Chemistry, Biochemistry and Biotechnology, University of
      Milan, Segrate, Milan, Italy. luigi.anastasia@unimi.it
FAU - Pelissero, G
AU  - Pelissero G
FAU - Venerando, B
AU  - Venerando B
FAU - Tettamanti, G
AU  - Tettamanti G
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100219
PL  - England
TA  - Cell Death Differ
JT  - Cell death and differentiation
JID - 9437445
RN  - 0 (Morpholines)
RN  - 0 (Purines)
RN  - Z499CLJ023 (2-(4-morpholinoanilino)-6-cyclohexylaminopurine)
SB  - IM
MH  - Adult Stem Cells/cytology/drug effects
MH  - Animals
MH  - Cell Differentiation
MH  - Cellular Reprogramming/*drug effects/genetics
MH  - Combinatorial Chemistry Techniques
MH  - Embryonic Stem Cells/cytology/drug effects
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*cytology/drug effects
MH  - Mice
MH  - Morpholines/pharmacology
MH  - Purines/pharmacology
MH  - Rats
MH  - Regenerative Medicine/*methods
RF  - 97
EDAT- 2010/02/20 06:00
MHDA- 2010/10/27 06:00
CRDT- 2010/02/20 06:00
PHST- 2010/02/20 06:00 [entrez]
PHST- 2010/02/20 06:00 [pubmed]
PHST- 2010/10/27 06:00 [medline]
AID - cdd201014 [pii]
AID - 10.1038/cdd.2010.14 [doi]
PST - ppublish
SO  - Cell Death Differ. 2010 Aug;17(8):1230-7. doi: 10.1038/cdd.2010.14. Epub 2010 Feb
      19.


PMID- 20167881
OWN - NLM
STAT- MEDLINE
DCOM- 20100408
LR  - 20211020
IS  - 1541-0048 (Electronic)
IS  - 0090-0036 (Linking)
VI  - 100
IP  - 4
DP  - 2010 Apr
TI  - Ethical considerations in surveys employing respondent-driven sampling.
PG  - 582-3; author reply 583-4
LID - 10.2105/AJPH.2009.184200 [doi]
FAU - Semaan, Salaam
AU  - Semaan S
FAU - Heckathorn, Douglas D
AU  - Heckathorn DD
FAU - Des Jarlais, Don C
AU  - Des Jarlais DC
FAU - Garfein, Richard S
AU  - Garfein RS
LA  - eng
GR  - 1R21NR01961/NR/NINR NIH HHS/United States
GR  - R0103574/PHS HHS/United States
PT  - Comment
PT  - Letter
PT  - Research Support, N.I.H., Extramural
DEP - 20100218
PL  - United States
TA  - Am J Public Health
JT  - American journal of public health
JID - 1254074
SB  - IM
CON - Am J Public Health. 2009 Sep;99(9):1562-7. PMID: 19608961
MH  - *Ethics, Medical
MH  - HIV Infections/psychology
MH  - *Health Surveys
MH  - Humans
MH  - Risk Factors
MH  - *Sampling Studies
MH  - Substance Abuse, Intravenous/psychology
PMC - PMC2836345
EDAT- 2010/02/20 06:00
MHDA- 2010/04/09 06:00
CRDT- 2010/02/20 06:00
PHST- 2010/02/20 06:00 [entrez]
PHST- 2010/02/20 06:00 [pubmed]
PHST- 2010/04/09 06:00 [medline]
AID - AJPH.2009.184200 [pii]
AID - 10.2105/AJPH.2009.184200 [doi]
PST - ppublish
SO  - Am J Public Health. 2010 Apr;100(4):582-3; author reply 583-4. doi:
      10.2105/AJPH.2009.184200. Epub 2010 Feb 18.


PMID- 20167833
OWN - NLM
STAT- MEDLINE
DCOM- 20101124
LR  - 20191210
IS  - 1938-2715 (Electronic)
IS  - 1049-9091 (Linking)
VI  - 27
IP  - 5
DP  - 2010 Aug
TI  - Reliability and validity of the Euthanasia Attitude Scale (EAS) for Hong Kong
      medical doctors.
PG  - 320-4
LID - 10.1177/1049909109358407 [doi]
AB  - This study aimed to examine the reliability and validity of the Euthanasia
      Attitude Scale (EAS) in Hong Kong medical doctors. A total of 107 medical doctors
      (61.7% men) participated in a survey at clinical settings in 2008. The 21-item
      EAS was used to assess their attitudes toward euthanasia. The mean (standard
      deviation) and median of the EAS were 63.60 (60.31) and 63.00. Total EAS scores
      correlated well with ''Ethical Considerations,'' ''Practical Considerations,''
      and ''Treasuring Life'' (Spearman rho =.37-.96, P < .001) but not ''Naturalistic 
      Beliefs.'' The construct validity of the 3-factor model was appropriate
      (Kaiser-Meyer-Olkin [KMO] value = 0.90) and showed high internal consistency
      (Cronbach alpha =.79-.92). Euthanasia Attitude Scale may be a reliable and valid 
      measure for assessing the attitudes toward euthanasia in medical professionals.
FAU - Tang, Wai-Kiu
AU  - Tang WK
AD  - Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.
FAU - Mak, Kwok-Kei
AU  - Mak KK
FAU - Kam, Philip Ming-Ho
AU  - Kam PM
FAU - Ho, Joanna Wing-Kiu
AU  - Ho JW
FAU - Chan, Denise Che-Ying
AU  - Chan DC
FAU - Suen, To-Lam
AU  - Suen TL
FAU - Lau, Michael Chak-Kwan
AU  - Lau MC
FAU - Cheng, Adrian Ka-Chun
AU  - Cheng AK
FAU - Wan, Yuen-Ting
AU  - Wan YT
FAU - Wan, Ho-Yan
AU  - Wan HY
FAU - Hussain, Assad
AU  - Hussain A
LA  - eng
PT  - Journal Article
PT  - Validation Study
DEP - 20100218
PL  - United States
TA  - Am J Hosp Palliat Care
JT  - The American journal of hospice & palliative care
JID - 9008229
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Attitude to Death
MH  - Cultural Characteristics
MH  - *Euthanasia
MH  - Female
MH  - Hong Kong
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Physicians/*statistics & numerical data
MH  - Practice Patterns, Physicians'/*standards
MH  - Psychometrics
MH  - Reproducibility of Results
MH  - Surveys and Questionnaires/*standards
EDAT- 2010/02/20 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/02/20 06:00
PHST- 2010/02/20 06:00 [entrez]
PHST- 2010/02/20 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 1049909109358407 [pii]
AID - 10.1177/1049909109358407 [doi]
PST - ppublish
SO  - Am J Hosp Palliat Care. 2010 Aug;27(5):320-4. doi: 10.1177/1049909109358407. Epub
      2010 Feb 18.


PMID- 20167773
OWN - NLM
STAT- MEDLINE
DCOM- 20100309
LR  - 20211020
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Linking)
VI  - 327
IP  - 5968
DP  - 2010 Feb 19
TI  - Research ethics. NIH guidelines for stem cell research and gamete donors.
PG  - 962-3
LID - 10.1126/science.1180725 [doi]
FAU - Lo, Bernard
AU  - Lo B
AD  - Program in Medical Ethics, University of California, San Francisco (UCSF), San
      Francisco, CA 94143, USA. bernie@medicine.ucsf.edu
FAU - Parham, Lindsay
AU  - Parham L
FAU - Cedars, Marcelle
AU  - Cedars M
FAU - Fisher, Susan
AU  - Fisher S
FAU - Gates, Elena
AU  - Gates E
FAU - Giudice, Linda
AU  - Giudice L
FAU - Halme, Dina Gould
AU  - Halme DG
FAU - Hershon, William
AU  - Hershon W
FAU - Kriegstein, Arnold
AU  - Kriegstein A
FAU - Rao, Radhika
AU  - Rao R
FAU - Roberts, Clifford
AU  - Roberts C
FAU - Wagner, Richard
AU  - Wagner R
LA  - eng
GR  - UL1 RR024131/RR/NCRR NIH HHS/United States
GR  - UL1 RR024131-04/RR/NCRR NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
SB  - IM
MH  - Cell Line
MH  - Disclosure
MH  - Embryo Disposition/*ethics/standards
MH  - Embryo Research/*ethics
MH  - *Embryonic Stem Cells
MH  - Female
MH  - Fertilization in Vitro
MH  - *Guidelines as Topic
MH  - Humans
MH  - Informed Consent
MH  - *National Institutes of Health (U.S.)
MH  - *Oocyte Donation
MH  - *Tissue Donors
MH  - United States
PMC - PMC2892655
MID - NIHMS203899
EDAT- 2010/02/20 06:00
MHDA- 2010/03/10 06:00
CRDT- 2010/02/20 06:00
PHST- 2010/02/20 06:00 [entrez]
PHST- 2010/02/20 06:00 [pubmed]
PHST- 2010/03/10 06:00 [medline]
AID - 327/5968/962 [pii]
AID - 10.1126/science.1180725 [doi]
PST - ppublish
SO  - Science. 2010 Feb 19;327(5968):962-3. doi: 10.1126/science.1180725.


PMID- 20167717
OWN - NLM
STAT- MEDLINE
DCOM- 20100706
LR  - 20100409
IS  - 1552-7409 (Electronic)
IS  - 0894-3184 (Linking)
VI  - 23
IP  - 2
DP  - 2010 Apr
TI  - Doing the right thing with families during critical life events.
PG  - 113-6
LID - 10.1177/0894318410362555 [doi]
AB  - With complex medical technology readily available for life-sustaining situations,
      making critical healthcare decisions has never been more arduous. Individuals,
      families, and communities face difficult circumstances, while all-at-once
      attempting to make decisions that are ethically considered to be doing the right 
      thing. What should the nurse do and how ought the nurse be with others during
      these moments of potentially divisive situations for families. This article
      begins a discussion of the ethical complexities for doing what is right in the
      midst of critical life events through the lens of the humanbecoming family model.
FAU - Milton, Constance L
AU  - Milton CL
AD  - California Baptist University, Riverside, CA 92504, USA.
      constancemilton@yahoo.com
LA  - eng
PT  - Journal Article
DEP - 20100218
PL  - United States
TA  - Nurs Sci Q
JT  - Nursing science quarterly
JID - 8805022
MH  - Aged, 80 and over
MH  - Decision Making/*ethics
MH  - Ethics, Nursing
MH  - Family/psychology
MH  - Female
MH  - Humans
MH  - Life Support Care/*ethics
MH  - Male
MH  - Models, Nursing
MH  - Professional-Family Relations/*ethics
MH  - United States
EDAT- 2010/02/20 06:00
MHDA- 2010/07/07 06:00
CRDT- 2010/02/20 06:00
PHST- 2010/02/20 06:00 [entrez]
PHST- 2010/02/20 06:00 [pubmed]
PHST- 2010/07/07 06:00 [medline]
AID - 0894318410362555 [pii]
AID - 10.1177/0894318410362555 [doi]
PST - ppublish
SO  - Nurs Sci Q. 2010 Apr;23(2):113-6. doi: 10.1177/0894318410362555. Epub 2010 Feb
      18.


PMID- 20167163
OWN - NLM
STAT- MEDLINE
DCOM- 20100712
LR  - 20211020
IS  - 1932-2968 (Electronic)
IS  - 1932-2968 (Linking)
VI  - 4
IP  - 1
DP  - 2010 Jan 1
TI  - Hypoglycemia detection in critical care using continuous glucose monitors: an in 
      silico proof of concept analysis.
PG  - 15-24
AB  - BACKGROUND: Tight glycemic control (TGC) in critical care has shown distinct
      benefits but has also been proven difficult to obtain. The risk of severe
      hypoglycemia (<40 mg/dl) has been increased significantly in several, but not
      all, studies, raising significant concerns for safety. Continuous glucose
      monitors (CGMs) offer frequent measurement and thus the possibility of using them
      for early detection alarms to prevent hypoglycemia. METHODS: This study used
      retrospective clinical data from the Specialized Relative Insulin Nutrition
      Titration TGC study covering seven patients who experienced severe hypoglycemic
      events. Clinically validated metabolic system models were used to recreate a
      continuous blood glucose profile. In silico analysis was enabled by using a
      conservative single Gaussian noise model based on reported CGM clinical data from
      a critical care study [mean absolute percent error (MAPE) 17.4%]. A novel median 
      filter was implemented and further smoothed with a least mean squares-fitted
      polynomial to reduce sensor noise. Two alarm approaches were compared. An
      integral-based method is presented that examined the area between a preset
      threshold and filtered simulated CGM data. An alarm was raised when this value
      became too low. A simple glycemic threshold method was also used for comparison. 
      To account for random noise skewing the results, each patient record was Monte
      Carlo simulated 100 times with a different random noise profile for a total of
      700 runs. Different alarm thresholds were analyzed parametrically. Results are
      reported in terms of detection time before the clinically measured event and any 
      false alarms. These retrospective clinical data were used with approval from the 
      New Zealand South Island Regional Ethics Committee. RESULTS: The median filter
      reduced MAPE from 17.4% [standard deviation (SD) 13%] to 9.3% (SD 7%) over the
      cohort. For the integral-based alarm, median per-patient detection times ranged, 
      t, from -35 minutes (before event) to -170 minutes, with zero to two false alarms
      per patient over the cohort and different alarm parameters. For a simple glycemic
      threshold alarm (three consecutive values below threshold), median per-patient
      alarm times were -10 to -75 minutes and false alarms were zero to seven; however,
      in one case, five of seven subjects never alarmed at all, despite the
      hypoglycemic event. CONCLUSIONS: A retrospective study used clinical hypoglycemic
      events from a TGC study to develop and analyze an integral-based hypoglycemia
      alarm for use in critical care TGC studies. The integral-based approach was
      accurate, provided significant lead time before a hypoglycemic event, alarmed at 
      higher glycemic levels, was robust to sensor noise, and had minimal false alarms.
      The approach is readily generalizable to similar scenarios, and results would
      justify a pilot clinical trial to verify this study.
CI  - 2010 Diabetes Technology Society.
FAU - Pretty, Christopher G
AU  - Pretty CG
AD  - Department of Mechanical Engineering, University of Canterbury, Christchurch, New
      Zealand.
FAU - Chase, J Geoffrey
AU  - Chase JG
FAU - Le Compte, Aaron
AU  - Le Compte A
FAU - Shaw, Geoffrey M
AU  - Shaw GM
FAU - Signal, Matthew
AU  - Signal M
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100101
PL  - United States
TA  - J Diabetes Sci Technol
JT  - Journal of diabetes science and technology
JID - 101306166
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Blood Glucose/*analysis
MH  - Clinical Alarms
MH  - *Computer Simulation
MH  - Concept Formation
MH  - Critical Care/*methods
MH  - Critical Illness/therapy
MH  - Early Diagnosis
MH  - Female
MH  - Humans
MH  - Hypoglycemia/*diagnosis/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Monitoring, Ambulatory/*instrumentation/methods
MH  - Research Design
MH  - Retrospective Studies
PMC - PMC2825620
EDAT- 2010/02/20 06:00
MHDA- 2010/07/14 06:00
CRDT- 2010/02/20 06:00
PHST- 2010/02/20 06:00 [entrez]
PHST- 2010/02/20 06:00 [pubmed]
PHST- 2010/07/14 06:00 [medline]
AID - 10.1177/193229681000400103 [doi]
PST - epublish
SO  - J Diabetes Sci Technol. 2010 Jan 1;4(1):15-24. doi: 10.1177/193229681000400103.


PMID- 20166807
OWN - NLM
STAT- MEDLINE
DCOM- 20100601
LR  - 20131121
IS  - 1091-7691 (Electronic)
IS  - 0895-8378 (Linking)
VI  - 22
IP  - 5
DP  - 2010 Apr
TI  - Simulations of exercise and brain effects of acute exposure to carbon monoxide in
      normal and vascular-diseased persons.
PG  - 417-26
LID - 10.3109/08958370903576806 [doi]
AB  - At some level, carboxyhemoglobin (COHb) due to inhalation of carbon monoxide (CO)
      reduces maximum exercise duration in both normal and ischemic heart patients. At 
      high COHb levels in normal subjects, brain function is also affected and
      behavioral performance is impaired.These are findings from published experiments 
      that are, due to ethical or practical considerations, incomplete in that higher
      or lower ranges of COHb, and exercise have not been well studied. To fill in this
      knowledge base, a whole-body human physiological model was used to make estimates
      of physiological functioning by the simulation of parametric exposures to CO and 
      various exercise levels. Ischemic heart disease was simulated by introducing a
      stenosis in the left heart arterial supply. Brain blood flow was also limited by 
      such a stenosis. To lend credibility to such estimation, the model was tested by 
      simulating experiments from the published literature. Simulations permitted
      several new conclusions. Increases in COHb produced the largest decreases in
      exercise duration when exercise was least strenuous and when COHb was smallest.
      For ischemic heart disease subjects, the greatest change in exercise duration
      produced by COHb increase was when ischemia and COHb was smallest. Brain aerobic 
      metabolism was unaffected until COHb exceeded 25%, unless the maximum brain blood
      supply was limited by a stenosis greater than 50% of normal. For higher levels of
      stenosis, aerobic brain metabolism was reduced for any increase in COHb level,
      implying that behavior would be impaired with no "threshold" for COHb.
FAU - Benignus, Vernon A
AU  - Benignus VA
AD  - Integrated Systems Toxicology Division, Systems Biology Branch, Health and
      Environmental Effects Research Laboratory, Office of Research and Development, US
      Environmental Protection Agency, Research Triangle Park, North Carolina, USA.
      tbenignus@earthlink.net
FAU - Coleman, Thomas G
AU  - Coleman TG
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - Inhal Toxicol
JT  - Inhalation toxicology
JID - 8910739
RN  - 7U1EE4V452 (Carbon Monoxide)
RN  - 9061-29-4 (Carboxyhemoglobin)
SB  - IM
MH  - Brain/blood supply/*drug effects/physiopathology
MH  - Carbon Monoxide/analysis/*toxicity
MH  - Carboxyhemoglobin/analysis
MH  - Computer Simulation
MH  - Environmental Monitoring
MH  - Exercise
MH  - Exercise Test
MH  - Heart/*drug effects
MH  - Humans
MH  - Models, Biological
MH  - Myocardial Ischemia/blood/*physiopathology
EDAT- 2010/02/20 06:00
MHDA- 2010/06/02 06:00
CRDT- 2010/02/20 06:00
PHST- 2010/02/20 06:00 [entrez]
PHST- 2010/02/20 06:00 [pubmed]
PHST- 2010/06/02 06:00 [medline]
AID - 10.3109/08958370903576806 [doi]
PST - ppublish
SO  - Inhal Toxicol. 2010 Apr;22(5):417-26. doi: 10.3109/08958370903576806.


PMID- 20166303
OWN - NLM
STAT- MEDLINE
DCOM- 20100318
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 7
IP  - 1
DP  - 2010 Jan-Mar
TI  - Process, pitfalls and probity: sharing experiences on setting up and running
      ethics committees in India.
PG  - 48-51
FAU - Bhan, Anant
AU  - Bhan A
AD  - Independent Researcher, Bioethics and Public Health, Flat 405, Building A-11,
      Planet Millennium, Aundh Camp, Pune 411 027, India. anantbhan@gmail.com
FAU - Desikan, Prabha
AU  - Desikan P
FAU - Swarnalakshmi, S
AU  - Swarnalakshmi S
FAU - Kalantri, S P
AU  - Kalantri SP
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Ethics Committees, Research/*organization & administration
MH  - Humans
MH  - India
EDAT- 2010/02/20 06:00
MHDA- 2010/03/20 06:00
CRDT- 2010/02/20 06:00
PHST- 2010/02/20 06:00 [entrez]
PHST- 2010/02/20 06:00 [pubmed]
PHST- 2010/03/20 06:00 [medline]
AID - 10.20529/IJME.2010.019 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2010 Jan-Mar;7(1):48-51. doi: 10.20529/IJME.2010.019.


PMID- 20166289
OWN - NLM
STAT- MEDLINE
DCOM- 20100318
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 7
IP  - 1
DP  - 2010 Jan-Mar
TI  - Impact of bioethics on patentability of inventions.
PG  - 14-7
AB  - This paper examines the impact of bioethics on patent claims. The increase in
      research activities involving human biological materials, and the rush to
      commercialise inventions derived from such biological materials, can at times
      result in unethical conduct of research. Questions arise as to whether patent law
      should concern itself with tainted research that has resulted in an invention or 
      whether it should grant patent rights solely on the basis of the technical
      improvements resulting from such research. This paper highlights the significance
      of ethical practice in biomedical research, an issue that may influence the
      decision to grant patents on inventions. It explores the relation between
      morality, bioethics and patents from the perspective of the objectives of the
      patent system and current developments in the law on patents. The inclusion of
      the morality provision in patent law introduces a mechanism through which
      inventions derived from tainted research can be filtered at an early stage.
FAU - Devaiah, Vishwas H
AU  - Devaiah VH
AD  - Liverpool Law School, University of Liverpool, Liverpool, UK.
      Vishwas.Devaiah@liverpool.ac.uk
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Biotechnology/*ethics
MH  - Humans
MH  - India
MH  - *Morals
MH  - Patents as Topic/*ethics
EDAT- 2010/02/20 06:00
MHDA- 2010/03/20 06:00
CRDT- 2010/02/20 06:00
PHST- 2010/02/20 06:00 [entrez]
PHST- 2010/02/20 06:00 [pubmed]
PHST- 2010/03/20 06:00 [medline]
AID - 10.20529/IJME.2010.005 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2010 Jan-Mar;7(1):14-7. doi: 10.20529/IJME.2010.005.


PMID- 20166288
OWN - NLM
STAT- MEDLINE
DCOM- 20100318
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 7
IP  - 1
DP  - 2010 Jan-Mar
TI  - Was the gadchiroli trial ethical? Response from the principal investigator.
PG  - 12-4
FAU - Bang, Abhay
AU  - Bang A
AD  - Society for Education, Action and Research in Community Health, Shodhgram P.O.
      Dist Gadchiroli, Maharashtra, India. search@satyam.net.in
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
CIN - Indian J Med Ethics. 2010 Jul-Sep;7(3):193-4. PMID: 20879084
CIN - Indian J Med Ethics. 2011 Jan-Mar;8(1):47-8. PMID: 22106601
MH  - Helsinki Declaration
MH  - Humans
MH  - India
MH  - Infant, Newborn
MH  - Moral Obligations
MH  - Randomized Controlled Trials as Topic/*ethics
MH  - Rural Health
MH  - Sepsis/*therapy
EDAT- 2010/02/20 06:00
MHDA- 2010/03/20 06:00
CRDT- 2010/02/20 06:00
PHST- 2010/02/20 06:00 [entrez]
PHST- 2010/02/20 06:00 [pubmed]
PHST- 2010/03/20 06:00 [medline]
AID - 10.20529/IJME.2010.004 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2010 Jan-Mar;7(1):12-4. doi: 10.20529/IJME.2010.004.


PMID- 20166287
OWN - NLM
STAT- MEDLINE
DCOM- 20100318
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 7
IP  - 1
DP  - 2010 Jan-Mar
TI  - Should the Bt brinjal controversy concern healthcare professionals and
      bioethicists?
PG  - 9-12
AB  - The Genetic Engineering Approval Committee's approval of Bt brinjal, the first
      genetically modified crop for human consumption in India, has sparked off
      protests across the country. This article questions the so-called benefits of GM 
      crops and highlights some major concerns. These include: inadequately addressed
      health and environmental risks, inadequate safety guidelines, a lack of
      transparency in sharing test data, the implications to seed sovereignty of
      farmers and the lack of informed choice for consumers. Some concerns about field 
      testing by Mahyco, the developer of Bt-brinjal, and the process of evaluation by 
      GEAC remain unresolved. With inadequate information about the crop's long-term
      safety, a precautionary approach is advocated before national policy allows
      commercial release of the seeds. A fair process is also needed in the public
      consultations being proposed by the minister of state for environment and
      forests. In addition to issues of procedural justice, a basic ethical question
      remains: do humans have a right to dominate the land and make expendable those
      creatures that they deem "undesirable"?
FAU - Seetharam, Sridevi
AU  - Seetharam S
AD  - Swami Vivekananda Youth Movement, Saragur, H D Kote Taluk, Mysore District 571
      121, India. desusridevi@gmail.com
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Agriculture/*ethics
MH  - Conflict of Interest
MH  - Environmental Health
MH  - *Food, Genetically Modified
MH  - Genetic Engineering/*ethics
MH  - Humans
MH  - India
MH  - Ownership
MH  - *Plants, Genetically Modified
MH  - Scientific Misconduct
MH  - Seeds
MH  - *Solanum melongena
EDAT- 2010/02/20 06:00
MHDA- 2010/03/20 06:00
CRDT- 2010/02/20 06:00
PHST- 2010/02/20 06:00 [entrez]
PHST- 2010/02/20 06:00 [pubmed]
PHST- 2010/03/20 06:00 [medline]
AID - 10.20529/IJME.2010.003 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2010 Jan-Mar;7(1):9-12. doi: 10.20529/IJME.2010.003.


PMID- 20166151
OWN - NLM
STAT- MEDLINE
DCOM- 20100617
LR  - 20211203
IS  - 1549-4918 (Electronic)
IS  - 1066-5099 (Linking)
VI  - 28
IP  - 3
DP  - 2010 Mar 31
TI  - Law, ethics, religion, and clinical translation in the 21st century--a discussion
      with Derek Hei. Interview by Majlinda Lako, Alan O. Trounson, Susan Rainey Daher.
PG  - 387-9
LID - 10.1002/stem.323 [doi]
FAU - Hei, Derek
AU  - Hei D
LA  - eng
PT  - Autobiography
PT  - Interview
PL  - England
TA  - Stem Cells
JT  - Stem cells (Dayton, Ohio)
JID - 9304532
SB  - IM
MH  - Academic Medical Centers/ethics/legislation & jurisprudence/trends
MH  - Biological Specimen Banks/ethics/legislation & jurisprudence/*trends
MH  - Cell Differentiation/genetics
MH  - Clinical Trials as Topic/ethics/legislation & jurisprudence/trends
MH  - Drug Design
MH  - Ethics, Medical
MH  - Humans
MH  - National Institutes of Health (U.S.)
MH  - Religion
MH  - Stem Cell Transplantation/ethics/legislation & jurisprudence/*trends
MH  - Stem Cells/*physiology
MH  - Translational Research, Biomedical/ethics/legislation & jurisprudence/*trends
MH  - United States
MH  - Wisconsin
PMC - PMC2962902
EDAT- 2010/02/19 06:00
MHDA- 2010/06/18 06:00
CRDT- 2010/02/19 06:00
PHST- 2010/02/19 06:00 [entrez]
PHST- 2010/02/19 06:00 [pubmed]
PHST- 2010/06/18 06:00 [medline]
AID - 10.1002/stem.323 [doi]
PST - ppublish
SO  - Stem Cells. 2010 Mar 31;28(3):387-9. doi: 10.1002/stem.323.


PMID- 20165576
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1920-1214 (Electronic)
IS  - 1911-6470 (Linking)
VI  - 4
IP  - 1
DP  - 2010 Feb
TI  - Patterns of computer and Internet usage among urology patients in two rural
      Northern Ontario communities.
PG  - 37-41
AB  - INTRODUCTION: We wanted to determine if the Internet can be used as a potential
      health promotion tool among urology patients in Northern Ontario. We identified
      patients' computer and Internet access and use patterns in Kirkland Lake and
      Kapuskasing, Ontario. MATERIALS AND METHODS: This study was reviewed and approved
      by the ethics boards of the Kapuskasing and Kirkland Lake hospitals and Brock
      University. Data were collected by hand-written questionnaires in English and
      French. We performed a descriptive analysis of the data obtained. RESULTS: Out of
      the 137 questionnaires distributed and collected, we achieved a 95% response rate
      (7 questionnaires were incomplete). There were 67 men (52 %) and 63 women (48%)
      ranging in age from 24 to 84 (mean 56). Languages spoken were English (57%),
      French (38%) and other (5%). We divided the responses into 3 groups: non-Internet
      users, those with a computer but no Internet access and Internet users. Internet 
      and non-Internet users were studied. Our results indicated that younger
      respondents, those with higher education and higher paying jobs, used the
      computer and Internet more often. The main reason behind their Internet was to
      seek health information for themselves, family and friends. CONCLUSION: About
      half of the respondents (55%) used the Internet to access health information.
      Patients' reactions toward online communication with their family physician were 
      mixed. One limitation of this study is the small sample size, which inhibits
      making far-reaching conclusions. Our results demonstrate that individual
      empowerment, access to health information and access to services via emerging
      technologies are important issues for urology patients in rural Northern Ontario.
FAU - Abara, Erinma
AU  - Abara E
AD  - University of Windsor, Faculty of Law, Canterbury College-Whitgift;
FAU - Narushima, Miya
AU  - Narushima M
FAU - Abara, Emmanuel O
AU  - Abara EO
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Urol Assoc J
JT  - Canadian Urological Association journal = Journal de l'Association des urologues 
      du Canada
JID - 101312644
PMC - PMC2811996
EDAT- 2010/02/19 06:00
MHDA- 2010/02/19 06:01
CRDT- 2010/02/19 06:00
PHST- 2010/02/19 06:00 [entrez]
PHST- 2010/02/19 06:00 [pubmed]
PHST- 2010/02/19 06:01 [medline]
AID - 10.5489/cuaj.772 [doi]
PST - ppublish
SO  - Can Urol Assoc J. 2010 Feb;4(1):37-41. doi: 10.5489/cuaj.772.


PMID- 20164303
OWN - NLM
STAT- MEDLINE
DCOM- 20100514
LR  - 20220309
IS  - 1477-9137 (Electronic)
IS  - 0021-9533 (Linking)
VI  - 123
IP  - Pt 5
DP  - 2010 Mar 1
TI  - Roadblocks en route to the clinical application of induced pluripotent stem
      cells.
PG  - 643-51
LID - 10.1242/jcs.054304 [doi]
AB  - Since the first studies of human embryonic stem cells (hESCs) and, more recently,
      human induced pluripotent stem cells (hiPSCs), the stem-cell field has been abuzz
      with the promise that these pluripotent populations will one day be a powerful
      therapeutic tool. Although it has been proposed that hiPSCs will supersede hESCs 
      with respect to their research and/or clinical potential because of the ease of
      their derivation and the ability to create immunologically matched iPSCs for each
      individual patient, recent evidence suggests that iPSCs in fact have several
      underappreciated characteristics that might mean they are less suitable for
      clinical application. Continuing research is revealing the similarities,
      differences and deficiencies of various pluripotent stem-cell populations, and
      suggests that many years will pass before the clinical utility of hESCs and
      hiPSCs is realized. There are a plethora of ethical, logistical and technical
      roadblocks on the route to the clinical application of pluripotent stem cells,
      particularly of iPSCs. In this Essay, we discuss what we believe are important
      issues that should be considered when attempting to bring hiPSC-based technology 
      to the clinic.
FAU - Lowry, William E
AU  - Lowry WE
AD  - Department of Molecular, Cell and Developmental Biology, 621 Charles Young Drive 
      South, University of California Los Angeles, Los Angeles, CA 90095, USA.
      blowry@ucla.edu
FAU - Quan, William L
AU  - Quan WL
LA  - eng
GR  - P01 GM099134/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Cell Sci
JT  - Journal of cell science
JID - 0052457
SB  - IM
MH  - Animals
MH  - Cell Differentiation/genetics/physiology
MH  - Cellular Reprogramming/genetics/physiology
MH  - Embryonic Stem Cells/cytology/metabolism
MH  - Government Agencies
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*cytology/metabolism
MH  - Stem Cell Transplantation/adverse effects/methods
MH  - United States
EDAT- 2010/02/19 06:00
MHDA- 2010/05/15 06:00
CRDT- 2010/02/19 06:00
PHST- 2010/02/19 06:00 [entrez]
PHST- 2010/02/19 06:00 [pubmed]
PHST- 2010/05/15 06:00 [medline]
AID - 123/5/643 [pii]
AID - 10.1242/jcs.054304 [doi]
PST - ppublish
SO  - J Cell Sci. 2010 Mar 1;123(Pt 5):643-51. doi: 10.1242/jcs.054304.


PMID- 20164163
OWN - NLM
STAT- MEDLINE
DCOM- 20100610
LR  - 20100218
IS  - 1461-7196 (Electronic)
IS  - 1363-4593 (Linking)
VI  - 14
IP  - 2
DP  - 2010 Mar
TI  - 'Do you feel sorry for him?': gift relations in an HIV/AIDS on-line support
      forum.
PG  - 147-61
LID - 10.1177/1363459309353296 [doi]
AB  - Sociologists have debated whether meaningful emotional relationships can be
      formed on-line. Drawing on Mauss' concept of the gift, I explore how caregivers
      who participate in Hope, an on-line support forum dedicated to HIV/AIDS,
      incorporate moral percepts and understandings about ethics into their caregiving 
      experiences. Their intense discussions on the essence of familial loyalties give 
      rise to emotionally vibrant, empathic communities in which a socio-emotional
      economy is formulated. Can the Internet act as a moral space? How are concepts
      such as reciprocity, obligation, and commitment talked about and practiced in an 
      on-line forum that exists in the ever present?
FAU - Bar-Lev, Shirly
AU  - Bar-Lev S
AD  - School of Engineering, Ruppin Academic Center, Israel. barlevsh@ruppin.ac.il
LA  - eng
PT  - Journal Article
PL  - England
TA  - Health (London)
JT  - Health (London, England : 1997)
JID - 9800465
SB  - IM
MH  - Attitude to Health
MH  - Caregivers/ethics/*psychology
MH  - Empathy
MH  - *Family Relations
MH  - HIV Infections/*psychology
MH  - Humans
MH  - *Internet
MH  - Moral Obligations
MH  - Prejudice
MH  - Self-Help Groups
EDAT- 2010/02/19 06:00
MHDA- 2010/06/11 06:00
CRDT- 2010/02/19 06:00
PHST- 2010/02/19 06:00 [entrez]
PHST- 2010/02/19 06:00 [pubmed]
PHST- 2010/06/11 06:00 [medline]
AID - 14/2/147 [pii]
AID - 10.1177/1363459309353296 [doi]
PST - ppublish
SO  - Health (London). 2010 Mar;14(2):147-61. doi: 10.1177/1363459309353296.


PMID- 20163208
OWN - NLM
STAT- MEDLINE
DCOM- 20110406
LR  - 20100728
IS  - 1937-3376 (Electronic)
IS  - 1937-3368 (Linking)
VI  - 16
IP  - 4
DP  - 2010 Aug
TI  - Ethical aspects of soft tissue engineering for congenital birth defects in
      children--what do experts in the field say?
PG  - 397-403
LID - 10.1089/ten.TEB.2009.0666 [doi]
AB  - This article is part of the EuroSTEC project, which aims at developing tissue
      engineering-based treatments for structural disorders present at birth. EuroSTEC 
      is positioned at the intersection of three areas with their own ethical issues:
      (1) regenerative medicine, (2) research with pregnant women and fetuses, and (3) 
      research with neonates. Because of the overlap of these three areas in this
      project, we can expect to be confronted with new ethical challenges. To be able
      to respond adequately and timely to current and possible future ethical issues, a
      prospective and anticipatory ethical analysis is essential. To obtain a first
      survey of ethical issues that might arise during the different phases of the
      project, the Delphi method was used. The professionals directly involved in the
      EuroSTEC project were questioned about their views on possible ethical issues.
      The first round yielded 27 ethical issues, which the respondents were asked to
      prioritize in the second round. For the fundamental research phase, issues deemed
      most important were privacy and informed consent of the tissue donor. For the
      animal experimentation phase, three issues were mentioned (in order of decreasing
      priority): the suffering of animals, the use of animals as means to an end, and
      the limited adequacy of the animal models. Issues that were deemed most important
      during the clinical (trial) phase pertained to the problem of weighing risks and 
      benefits for the fetus/child and the pregnant woman.
FAU - Oerlemans, Anke J M
AU  - Oerlemans AJ
AD  - Scientific Institute for Quality of Healthcare, Section Ethics, Philosophy, and
      History of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The
      Netherlands. a.oerlemans@iq.umcn.nl
FAU - Rodrigues, Catarina H C M L
AU  - Rodrigues CH
FAU - Verkerk, Marian A
AU  - Verkerk MA
FAU - van den Berg, Paul P
AU  - van den Berg PP
FAU - Dekkers, Wim J M
AU  - Dekkers WJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Tissue Eng Part B Rev
JT  - Tissue engineering. Part B, Reviews
JID - 101466660
SB  - IM
MH  - Animal Experimentation/ethics
MH  - Animals
MH  - Biomedical Research/ethics
MH  - Child
MH  - Clinical Trials as Topic/ethics
MH  - Congenital Abnormalities/*therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Tissue Engineering/*ethics
EDAT- 2010/02/19 06:00
MHDA- 2011/04/07 06:00
CRDT- 2010/02/19 06:00
PHST- 2010/02/19 06:00 [entrez]
PHST- 2010/02/19 06:00 [pubmed]
PHST- 2011/04/07 06:00 [medline]
AID - 10.1089/ten.TEB.2009.0666 [doi]
PST - ppublish
SO  - Tissue Eng Part B Rev. 2010 Aug;16(4):397-403. doi: 10.1089/ten.TEB.2009.0666.


PMID- 20162678
OWN - NLM
STAT- MEDLINE
DCOM- 20100315
LR  - 20211028
IS  - 1097-4598 (Electronic)
IS  - 0148-639X (Linking)
VI  - 41
IP  - 3
DP  - 2010 Mar
TI  - Perioral skin biopsy to study skeletal muscle protein expression.
PG  - 392-8
LID - 10.1002/mus.21506 [doi]
AB  - Clinical trials for muscular dystrophy molecular treatment require multiple
      sampling of skeletal muscle to monitor protein rescue. This practice is invasive 
      and could raise ethical problems. A less invasive tool to obtain sequential
      muscle sampling is necessary. Using indirect immunofluorescence, we evaluated
      muscle protein expression in myofiber bundles included in 2-2.5-mm punch skin
      biopsies from the perioral region from 6 healthy subjects and 6 patients with
      genetically defined forms of muscular dystrophy. Large intradermal bundles of
      orbicularis oris muscle were constantly present in skin biopsies. They showed a
      typical muscular antigenic pattern in controls and the expected protein defect in
      muscular dystrophy patients. These results demonstrate the feasibility of
      muscular protein expression analysis using skin biopsy. We propose this minimally
      invasive technique to follow-up the response to genetic or conventional therapies
      in muscular dystrophies and to confirm the diagnosis in some special clinical
      conditions.
FAU - Santoro, Lucio
AU  - Santoro L
AD  - Department of Neurological Sciences, University Federico II, Via Sergio Pansini
      5, 80131 Naples, Italy. lusantor@unina.it
FAU - Nolano, Maria
AU  - Nolano M
FAU - Faraso, Stefania
AU  - Faraso S
FAU - Fiorillo, Chiara
AU  - Fiorillo C
FAU - Vitiello, Carmen
AU  - Vitiello C
FAU - Provitera, Vincenzo
AU  - Provitera V
FAU - Aurino, Stefania
AU  - Aurino S
FAU - Nigro, Vincenzo
AU  - Nigro V
LA  - eng
GR  - TGM06F01/TI_/Telethon/Italy
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Muscle Nerve
JT  - Muscle & nerve
JID - 7803146
RN  - 0 (Muscle Proteins)
SB  - IM
MH  - Adult
MH  - Biopsy, Needle/*methods
MH  - Face
MH  - Female
MH  - Fluorescent Antibody Technique
MH  - Humans
MH  - Male
MH  - Microscopy, Confocal
MH  - Middle Aged
MH  - Muscle Proteins/metabolism
MH  - Muscle, Skeletal/*metabolism/pathology
MH  - Muscular Dystrophies/*metabolism/pathology
MH  - Patient Selection
MH  - Skin/*metabolism/pathology
EDAT- 2010/02/18 06:00
MHDA- 2010/03/17 06:00
CRDT- 2010/02/18 06:00
PHST- 2010/02/18 06:00 [entrez]
PHST- 2010/02/18 06:00 [pubmed]
PHST- 2010/03/17 06:00 [medline]
AID - 10.1002/mus.21506 [doi]
PST - ppublish
SO  - Muscle Nerve. 2010 Mar;41(3):392-8. doi: 10.1002/mus.21506.


PMID- 20162468
OWN - NLM
STAT- MEDLINE
DCOM- 20100810
LR  - 20211020
IS  - 1559-0305 (Electronic)
IS  - 1073-6085 (Linking)
VI  - 45
IP  - 2
DP  - 2010 Jun
TI  - Progenitor cells for regenerative medicine and consequences of ART and
      cloning-associated epimutations.
PG  - 187-97
LID - 10.1007/s12033-010-9252-y [doi]
AB  - The "holy grail" of regenerative medicine is the identification of an
      undifferentiated progenitor cell that is pluripotent, patient specific, and
      ethically unambiguous. Such a progenitor cell must also be able to differentiate 
      into functional, transplantable tissue, while avoiding the risks of immune
      rejection. With reports detailing aberrant genomic imprinting associated with
      assisted reproductive technologies (ART) and reproductive cloning, the idea that 
      human embryonic stem cells (hESCs) derived from surplus in vitro fertilized
      embryos or nuclear transfer ESCs (ntESCs) harvested from cloned embryos may
      harbor dangerous epigenetic errors has gained attention. Various progenitor cell 
      sources have been proposed for human therapy, from hESCs to ntESCs, and from
      adult stem cells to induced pluripotent stem cells (iPS and piPS cells). This
      review highlights the advantages and disadvantages of each of these technologies,
      with particular emphasis on epigenetic stability.
FAU - Laprise, Shari L
AU  - Laprise SL
AD  - Math/Science Division, Babson College, Babson Park, MA 02457, USA.
      slaprise@babson.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Mol Biotechnol
JT  - Molecular biotechnology
JID - 9423533
SB  - IM
MH  - Animals
MH  - Cellular Reprogramming
MH  - *Epigenesis, Genetic
MH  - Humans
MH  - *Regenerative Medicine
MH  - Reproductive Techniques, Assisted
MH  - Stem Cells/*physiology
RF  - 127
EDAT- 2010/02/18 06:00
MHDA- 2010/08/11 06:00
CRDT- 2010/02/18 06:00
PHST- 2010/02/18 06:00 [entrez]
PHST- 2010/02/18 06:00 [pubmed]
PHST- 2010/08/11 06:00 [medline]
AID - 10.1007/s12033-010-9252-y [doi]
PST - ppublish
SO  - Mol Biotechnol. 2010 Jun;45(2):187-97. doi: 10.1007/s12033-010-9252-y.


PMID- 20160762
OWN - NLM
STAT- MEDLINE
DCOM- 20100303
LR  - 20100217
IS  - 0807-7096 (Electronic)
IS  - 0029-2001 (Linking)
VI  - 130
IP  - 3
DP  - 2010 Feb 11
TI  - [Publication ethics--responsibility of all].
PG  - 259
LID - 10.4045/tidsskr.10.0014 [doi]
FAU - Staff, Annetine
AU  - Staff A
FAU - Rortveit, Guri
AU  - Rortveit G
LA  - nor
PT  - Editorial
TT  - Publiseringsetikk--et felles ansvar.
PL  - Norway
TA  - Tidsskr Nor Laegeforen
JT  - Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny
      raekke
JID - 0413423
SB  - IM
MH  - Editorial Policies
MH  - Humans
MH  - Peer Review, Research/ethics/standards
MH  - *Periodicals as Topic/ethics/standards
MH  - Publishing/*ethics/standards
MH  - Scientific Misconduct
EDAT- 2010/02/18 06:00
MHDA- 2010/03/04 06:00
CRDT- 2010/02/18 06:00
PHST- 2010/02/18 06:00 [entrez]
PHST- 2010/02/18 06:00 [pubmed]
PHST- 2010/03/04 06:00 [medline]
AID - 1942807 [pii]
AID - 10.4045/tidsskr.10.0014 [doi]
PST - ppublish
SO  - Tidsskr Nor Laegeforen. 2010 Feb 11;130(3):259. doi: 10.4045/tidsskr.10.0014.


PMID- 20160544
OWN - NLM
STAT- MEDLINE
DCOM- 20100514
LR  - 20100217
IS  - 1538-8646 (Electronic)
IS  - 0730-4625 (Linking)
VI  - 29
IP  - 2
DP  - 2010 Mar-Apr
TI  - Progress in ethical decision making in the care of the dying.
PG  - 73-80
LID - 10.1097/DCC.0b013e3181c9301a [doi]
AB  - Practitioners in critical care have made a significant progress in caring for
      dying patients in critical care by taking advantage of the suggestions from their
      professional groups. Progress has been made in responding to and controlling
      patients' pain. Major initiatives from the Joint Commission and the American Pain
      Society have helped direct this improvement. Palliative care consultations as
      well as ethics consultations have improved symptom control in the critically ill.
      Issues of consent have been problematic for dying patients in critical care
      especially in the area of discontinuing therapies. But, better policies related
      to advance directives have been developed to ensure good care. Spiritual care has
      received more attention, and now chaplains are recognized by the Society for
      Critical Care Medicine as integral to the critical care team. The American
      Association of Critical-Care Nurses has been a leader in improving end-of-life
      issues and continues to spearhead many projects to improve end-of-life care.
FAU - Ott, Barbara B
AU  - Ott BB
AD  - College of Nursing, Villanova University, Villanova, Pennsylvania 19085, USA.
      barbara.ott@villanova.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Dimens Crit Care Nurs
JT  - Dimensions of critical care nursing : DCCN
JID - 8211489
MH  - Advance Care Planning/ethics/organization & administration
MH  - Chaplaincy Service, Hospital/ethics/organization & administration
MH  - *Critical Care/ethics/organization & administration
MH  - Decision Making/ethics
MH  - Ethics Consultation/ethics/organization & administration
MH  - *Evidence-Based Practice/ethics/organization & administration
MH  - Humans
MH  - Leadership
MH  - Pain/prevention & control
MH  - *Palliative Care/ethics/organization & administration
MH  - Patient Care Team/ethics/organization & administration
MH  - Practice Guidelines as Topic
MH  - Restraint, Physical
MH  - Specialties, Nursing/ethics/organization & administration
MH  - Spirituality
MH  - Total Quality Management/*organization & administration
MH  - United States
MH  - Withholding Treatment/ethics
EDAT- 2010/02/18 06:00
MHDA- 2010/05/15 06:00
CRDT- 2010/02/18 06:00
PHST- 2010/02/18 06:00 [entrez]
PHST- 2010/02/18 06:00 [pubmed]
PHST- 2010/05/15 06:00 [medline]
AID - 10.1097/DCC.0b013e3181c9301a [doi]
AID - 00003465-201003000-00007 [pii]
PST - ppublish
SO  - Dimens Crit Care Nurs. 2010 Mar-Apr;29(2):73-80. doi:
      10.1097/DCC.0b013e3181c9301a.


PMID- 20160438
OWN - NLM
STAT- MEDLINE
DCOM- 20101025
LR  - 20181201
IS  - 1421-9700 (Electronic)
IS  - 1420-3030 (Linking)
VI  - 15
IP  - 5
DP  - 2010
TI  - Preimplantation genetic diagnosis (embryo screening) for enlarged vestibular
      aqueduct due to SLC26A4 mutation.
PG  - 311-7
LID - 10.1159/000284349 [doi]
AB  - Preimplantation genetic diagnosis (PGD) is used to analyze embryos genetically
      before their transfer into the uterus. For families with genetic diseases, PGD
      offers a chance to have an unaffected child, without facing termination of
      pregnancy. Although PGD has been performed for many monogenic disorders, such as 
      cystic fibrosis and beta-thalassemia, the application of PGD to hereditary
      hearing impairment has not been explored. In the present study, we reported the
      development and application of PGD protocols to address enlarged vestibular
      aqueduct (EVA), which is a common type of hereditary hearing impairment
      associated with mutations in the SLC26A4 gene. The family requesting PGD had a
      history of EVA, segregating the SLC26A4 c.919-2A-->G mutation. In short, the PGD 
      process was composed of two steps: the development of a single-cell testing
      protocol and clinical PGD cycles (i.e., selection and implantation of unaffected 
      embryos using the single-cell testing protocol). First, protocols for genetic
      testing in a single cell were established for the c.919-2A-->G mutation using
      GenomiPhi technology and primer extension mini-sequencing. These protocols were
      validated on single lymphocytes collected from both parents and their affected
      child. Two clinical PGD cycles were then performed for the parents, with the
      second cycle successfully leading to a singleton pregnancy. The baby was
      homozygous for the wild-type SLC26A4 allele and revealed a normal audiological
      phenotype after birth. To our knowledge, this is the first report in the
      literature describing successful PGD in families with genetic hearing impairment.
      In our opinion, the application of PGD in the field of hereditary hearing
      impairment involves fewer ethical controversies than other novel applications of 
      PGD and traditional indications for PGD for other monogenic diseases. Therefore, 
      the approach demonstrated in the present study can also be used in a large number
      of families with other types of hereditary hearing impairment.
CI  - Copyright 2010 S. Karger AG, Basel.
FAU - Wu, Chen-Chi
AU  - Wu CC
AD  - Department of Otolaryngology, National Taiwan University Hospital, Taipei,
      Taiwan, ROC.
FAU - Lin, Shin-Yu
AU  - Lin SY
FAU - Su, Yi-Nin
AU  - Su YN
FAU - Fang, Mei-Ya
AU  - Fang MY
FAU - Chen, Shee-Uan
AU  - Chen SU
FAU - Hsu, Chuan-Jen
AU  - Hsu CJ
LA  - eng
PT  - Journal Article
DEP - 20100217
PL  - Switzerland
TA  - Audiol Neurootol
JT  - Audiology & neuro-otology
JID - 9606930
RN  - 0 (Membrane Transport Proteins)
RN  - 0 (SLC26A4 protein, human)
RN  - 0 (Sulfate Transporters)
SB  - IM
MH  - Embryo Transfer
MH  - Female
MH  - Hearing Loss/*diagnosis/genetics
MH  - Humans
MH  - Membrane Transport Proteins/*genetics
MH  - Mutation
MH  - Pregnancy
MH  - *Preimplantation Diagnosis
MH  - Sulfate Transporters
MH  - Vestibular Aqueduct/*abnormalities
EDAT- 2010/02/18 06:00
MHDA- 2010/10/26 06:00
CRDT- 2010/02/18 06:00
PHST- 2009/08/07 00:00 [received]
PHST- 2009/12/23 00:00 [accepted]
PHST- 2010/02/18 06:00 [entrez]
PHST- 2010/02/18 06:00 [pubmed]
PHST- 2010/10/26 06:00 [medline]
AID - 000284349 [pii]
AID - 10.1159/000284349 [doi]
PST - ppublish
SO  - Audiol Neurootol. 2010;15(5):311-7. doi: 10.1159/000284349. Epub 2010 Feb 17.


PMID- 20160281
OWN - NLM
STAT- MEDLINE
DCOM- 20100520
LR  - 20220309
IS  - 1554-3528 (Electronic)
IS  - 1554-351X (Linking)
VI  - 42
IP  - 1
DP  - 2010 Feb
TI  - Improved stopping rules for the design of efficient small-sample experiments in
      biomedical and biobehavioral research.
PG  - 3-22
LID - 10.3758/BRM.42.1.3 [doi]
AB  - Sequential stopping rules (SSRs) should augment traditional hypothesis tests in
      many planned experiments, because they can provide the same statistical power
      with up to 30% fewer subjects without additional education or software. This
      article includes new Monte-Carlo-generated power curves and tables of stopping
      criteria based on the p values from simulated t tests and one-way ANOVAs. The
      tables improve existing SSR techniques by holding alpha very close to a target
      value when 1-10 subjects are added at each iteration. The emphasis is on small
      sample sizes (3-40 subjects per group) and large standardized effect sizes
      (0.8-2.0). The generality of the tables for dependent samples and one-tailed
      tests is discussed. SSR methods should be of interest to ethics bodies governing 
      research when it is desirable to limit the number of subjects tested, such as in 
      studies of pain, experimental disease, or surgery with animal or human subjects.
FAU - Fitts, Douglas A
AU  - Fitts DA
AD  - University of Washington, Seattle, WA, USA. dfitts@u.washington.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Behav Res Methods
JT  - Behavior research methods
JID - 101244316
SB  - IM
MH  - Behavioral Research/*methods
MH  - Biomedical Research/*methods
MH  - Humans
MH  - *Research Design
MH  - Sampling Studies
EDAT- 2010/02/18 06:00
MHDA- 2010/05/21 06:00
CRDT- 2010/02/18 06:00
PHST- 2010/02/18 06:00 [entrez]
PHST- 2010/02/18 06:00 [pubmed]
PHST- 2010/05/21 06:00 [medline]
AID - 42/1/3 [pii]
AID - 10.3758/BRM.42.1.3 [doi]
PST - ppublish
SO  - Behav Res Methods. 2010 Feb;42(1):3-22. doi: 10.3758/BRM.42.1.3.


PMID- 20159198
OWN - NLM
STAT- MEDLINE
DCOM- 20100520
LR  - 20191210
IS  - 0013-7006 (Print)
IS  - 0013-7006 (Linking)
VI  - 36
IP  - 1
DP  - 2010 Feb
TI  - [Implementing a pluridisciplinary network of intimate partner violence
      prevention].
PG  - 62-8
LID - 10.1016/j.encep.2008.11.004 [doi]
AB  - INTRODUCTION: The victims of a spouse's violence have a high risk of developing
      mental and physical health symptoms. The efforts aimed at preventing the
      consequences of domestic violence are encouraged by the current literature as
      well as the national and international recommendations. They highlight the fact
      that intervention and treatment programs have more or less failed. BACKGROUND:
      This publication introduces the main stages of the implementation of a network,
      the main goals of which are to improve the knowledge and professional practices
      aimed at the victims of domestic violence, and to enhance the continuation and
      quality of health and social care (screening, assessment and addressing). After
      relating the developments and the methodology of the victims' consultations
      carried out, we will show how such a network device enables one to exceed the
      usual practice limits. First, we point out certain specificities pertaining to
      postimmediate psychological care (psychological debriefing) of victims of
      intimate partner violence. METHODOLOGY: After presenting a specific methodology
      of assessment of the global situation of the victim, three illustrations of the
      specific consequences of domestic violence will be made, in order to highlight
      the interest of collaborating between professionals who are used to tackling this
      issue. First, is the way to empower women and help them to avoid assaults and
      thus prevent victimisation. The overall goal of this specific intervention is to 
      teach women that they can end the cycle of perpetuating of intimate partner
      violence by learning safety factors, such as what to do if more violence occurs
      and where and how to seek assistance if it were to recur. Second, is to prevent
      the consequences of domestic violence on a child's development. It is based on
      the fact that children who witness domestic violence are negatively affected, as 
      children who witness abuse are likely to experience a number of psychological
      symptoms. So the network proposes preventive measures and specific addressing to 
      reduce the impact of violence. The third example relates to the high proportion
      of sexual assault among the nature of violence women suffer from. Victims of
      marital rape experience significant levels of negative mental and physical health
      symptoms. Network professionals have improved the screening of sexual assault in 
      order to propose to the victims specific addressing, in terms of gynaecologic and
      psychological care. DISCUSSION: As a consequence, we deal with the professional
      and deontological positioning that the medical professionals have towards this
      device. The network device aims at going beyond the limits of the usual care,
      both through a pooling of knowledge and multidisciplinary practices. The
      establishment of common models of intervention (working groups), also suggests a 
      best practice in relation to complex issues: the establishment of a network is a 
      means of establishing the link between professionals. However, professionals in a
      network should routinely question their practice and ethics and to avoid
      "confusion of roles" - the risk of multidisciplinary and standard practices.
      Differences and professional specialisation are essential components of a care
      offer tailored to the clinical complexity of victims of domestic violence. It now
      appears necessary to assess the impact of this care at the social, health and
      psychological levels of victims of domestic violence.
CI  - Copyright (c) 2009 L'Encephale, Paris. Published by Elsevier Masson SAS. All
      rights reserved.
FAU - Bazex, H
AU  - Bazex H
AD  - Direction de la recherche CIRAP, ENAP, association Previos, 440, avenue
      Michel-Serres, BP 28, 47916 Agen cedex 9, France. helene.bazex@justice.fr
FAU - Thomas, A
AU  - Thomas A
FAU - Combalbert, N
AU  - Combalbert N
FAU - Lignon, S
AU  - Lignon S
LA  - fre
PT  - Journal Article
TT  - La creation d'un reseau pluridisciplinaire de prevention de la violence
      conjugale.
DEP - 20090306
PL  - France
TA  - Encephale
JT  - L'Encephale
JID - 7505643
SB  - IM
MH  - Adult
MH  - Child
MH  - Child Abuse/prevention & control/psychology
MH  - Child of Impaired Parents/psychology
MH  - Combined Modality Therapy
MH  - Cooperative Behavior
MH  - Crisis Intervention
MH  - Female
MH  - *Health Plan Implementation
MH  - Humans
MH  - Interdisciplinary Communication
MH  - Mass Screening
MH  - Outcome and Process Assessment, Health Care
MH  - *Patient Care Team
MH  - Rape/prevention & control/psychology
MH  - Secondary Prevention
MH  - Spouse Abuse/*prevention & control/psychology
MH  - Violence/*prevention & control/psychology
EDAT- 2010/02/18 06:00
MHDA- 2010/05/21 06:00
CRDT- 2010/02/18 06:00
PHST- 2008/06/02 00:00 [received]
PHST- 2008/11/24 00:00 [accepted]
PHST- 2010/02/18 06:00 [entrez]
PHST- 2010/02/18 06:00 [pubmed]
PHST- 2010/05/21 06:00 [medline]
AID - S0013-7006(09)00008-6 [pii]
AID - 10.1016/j.encep.2008.11.004 [doi]
PST - ppublish
SO  - Encephale. 2010 Feb;36(1):62-8. doi: 10.1016/j.encep.2008.11.004. Epub 2009 Mar
      6.


PMID- 20158989
OWN - NLM
STAT- MEDLINE
DCOM- 20100729
LR  - 20220330
IS  - 1472-6491 (Electronic)
IS  - 1472-6483 (Linking)
VI  - 20
IP  - 1
DP  - 2010 Jan
TI  - Failed fertilization after clinical intracytoplasmic sperm injection.
PG  - 56-67
LID - 10.1016/j.rbmo.2009.10.010 [doi]
AB  - Intracytoplasmic sperm injection (ICSI) has resulted in pregnancy and birth for
      many couples, including those with severe male factor infertility. However, even 
      after ICSI, complete failure of fertilization occurs in 1-3% of cycles. Most
      cases occur due to low number of mature oocytes, failure of oocyte activation or 
      non-availability of appropriate spermatozoa for injection. Given the significant 
      emotional and financial involvement in assisted reproductive cycles, failure of
      fertilization in all mature oocytes is a distressful event. It is not
      predictable. Since follow-up ICSI cycles result in fertilization in 85% of cases,
      repeated ICSI attempts are suggested. Physicians should counsel patients
      experiencing repeated failure of fertilization after ICSI cycles about available 
      options including donated oocytes/embryos, donor sperm insemination, adoption or 
      remaining childless if these choices are not acceptable due to religious or
      ethical reasons. This review discusses the causes and remedies for failed
      fertilization after clinical ICSI.
CI  - Copyright (c) 2009 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All
      rights reserved.
FAU - Javed, Murid
AU  - Javed M
AD  - Toronto Centre for Advanced Reproductive Technology (TCART), 210-150 Bloor Street
      (W), Toronto, Ont., Canada M5S 2X9. murid.javed@gmail.com
FAU - Esfandiari, Navid
AU  - Esfandiari N
FAU - Casper, Robert F
AU  - Casper RF
LA  - eng
PT  - Journal Article
PT  - Retracted Publication
PT  - Review
DEP - 20091030
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
SB  - IM
RIN - Reprod Biomed Online. 2011 Dec;23(6):806. PMID: 22250297
MH  - Female
MH  - Fertilization in Vitro/*adverse effects
MH  - Humans
MH  - Infertility, Male/*therapy
MH  - Male
MH  - Oocyte Donation
MH  - Oocytes/physiology
MH  - Sperm Injections, Intracytoplasmic/*adverse effects
MH  - Tissue Donors
MH  - Treatment Failure
RF  - 123
EDAT- 2010/02/18 06:00
MHDA- 2010/07/30 06:00
CRDT- 2010/02/18 06:00
PHST- 2009/02/23 00:00 [received]
PHST- 2009/05/06 00:00 [revised]
PHST- 2009/09/10 00:00 [accepted]
PHST- 2010/02/18 06:00 [entrez]
PHST- 2010/02/18 06:00 [pubmed]
PHST- 2010/07/30 06:00 [medline]
AID - S1472-6483(09)00153-9 [pii]
AID - 10.1016/j.rbmo.2009.10.010 [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2010 Jan;20(1):56-67. doi: 10.1016/j.rbmo.2009.10.010. Epub
      2009 Oct 30.


PMID- 20158899
OWN - NLM
STAT- MEDLINE
DCOM- 20100330
LR  - 20211020
IS  - 1471-2288 (Electronic)
IS  - 1471-2288 (Linking)
VI  - 10
DP  - 2010 Feb 16
TI  - Electronic search strategies to identify reports of cluster randomized trials in 
      MEDLINE: low precision will improve with adherence to reporting standards.
PG  - 15
LID - 10.1186/1471-2288-10-15 [doi]
AB  - BACKGROUND: Cluster randomized trials (CRTs) present unique methodological and
      ethical challenges. Researchers conducting systematic reviews of CRTs (e.g.,
      addressing methodological or ethical issues) require efficient electronic search 
      strategies (filters or hedges) to identify trials in electronic databases such as
      MEDLINE. According to the CONSORT statement extension to CRTs, the clustered
      design should be clearly identified in titles or abstracts; however, variability 
      in terminology may make electronic identification challenging. Our objectives
      were to (a) evaluate sensitivity ("recall") and precision of a well-known
      electronic search strategy ("randomized controlled trial" as publication type)
      with respect to identifying CRTs, (b) evaluate the feasibility of new search
      strategies targeted specifically at CRTs, and (c) determine whether CRTs are
      appropriately identified in titles or abstracts of reports and whether there has 
      been improvement over time. METHODS: We manually examined a wide range of health 
      journals to identify a gold standard set of CRTs. Search strategies were
      evaluated against the gold standard set, as well as an independent set of CRTs
      included in previous systematic reviews. RESULTS: The existing strategy
      (randomized controlled trial.pt) is sensitive (93.8%) for identifying CRTs, but
      has relatively low precision (9%, number needed to read 11); the number needed to
      read can be halved to 5 (precision 18.4%) by combining with cluster
      design-related terms using the Boolean operator AND; combining with the Boolean
      operator OR maximizes sensitivity (99.4%) but would require 28.6 citations read
      to identify one CRT. Only about 50% of CRTs are clearly identified as cluster
      randomized in titles or abstracts; approximately 25% can be identified based on
      the reported units of randomization but are not amenable to electronic searching;
      the remaining 25% cannot be identified except through manual inspection of the
      full-text article. The proportion of trials clearly identified has increased from
      28% between the years 2000-2003, to 60% between 2004-2007 (absolute increase 32%,
      95% CI 17 to 47%). CONCLUSIONS: CRTs should include the phrase "cluster
      randomized trial" in titles or abstracts; this will facilitate more accurate
      indexing of the publication type by reviewers at the National Library of
      Medicine, and efficient textword retrieval of the subset employing cluster
      randomization.
FAU - Taljaard, Monica
AU  - Taljaard M
AD  - Ottawa Hospital Research Institute, Clinical Epidemiology Program, Ottawa,
      Canada. mtaljaard@ohri.ca
FAU - McGowan, Jessie
AU  - McGowan J
FAU - Grimshaw, Jeremy M
AU  - Grimshaw JM
FAU - Brehaut, Jamie C
AU  - Brehaut JC
FAU - McRae, Andrew
AU  - McRae A
FAU - Eccles, Martin P
AU  - Eccles MP
FAU - Donner, Allan
AU  - Donner A
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100216
PL  - England
TA  - BMC Med Res Methodol
JT  - BMC medical research methodology
JID - 100968545
SB  - IM
MH  - Abstracting and Indexing/standards
MH  - Information Storage and Retrieval/*methods/standards
MH  - *MEDLINE
MH  - *Randomized Controlled Trials as Topic
MH  - Reproducibility of Results
PMC - PMC2833170
EDAT- 2010/02/18 06:00
MHDA- 2010/03/31 06:00
CRDT- 2010/02/18 06:00
PHST- 2009/09/22 00:00 [received]
PHST- 2010/02/16 00:00 [accepted]
PHST- 2010/02/18 06:00 [entrez]
PHST- 2010/02/18 06:00 [pubmed]
PHST- 2010/03/31 06:00 [medline]
AID - 1471-2288-10-15 [pii]
AID - 10.1186/1471-2288-10-15 [doi]
PST - epublish
SO  - BMC Med Res Methodol. 2010 Feb 16;10:15. doi: 10.1186/1471-2288-10-15.


PMID- 20158556
OWN - NLM
STAT- MEDLINE
DCOM- 20100504
LR  - 20211020
IS  - 1532-5415 (Electronic)
IS  - 0002-8614 (Linking)
VI  - 58
IP  - 3
DP  - 2010 Mar
TI  - Physicians' views on the importance of patient preferences in surrogate
      decision-making.
PG  - 533-8
LID - 10.1111/j.1532-5415.2010.02720.x [doi]
AB  - OBJECTIVES: To explore the degree to which physicians report reliance on patient 
      preferences when making medical decisions for hospitalized patients lacking
      decisional capacity. DESIGN: Cross-sectional survey. SETTING: One academic and
      two community hospitals in a single metropolitan area. PARTICIPANTS: Two hundred 
      eighty-one physicians who recently cared for hospitalized adults. MEASUREMENTS: A
      self-administered survey addressing physicians' beliefs about ethical principles 
      guiding surrogate decision-making and physicians' recent decision-making
      experiences. RESULTS: Overall, 72.6% of physicians identified a standard related 
      to patient preferences as the most important ethical standard for surrogate
      decision-making (61.2% identified advanced directives and 11.4% substituted
      judgment). Of the 73.3% of physicians who reported recently making a surrogate
      decision, 81.8% reported that patient preferences were highly important in
      decision-making, although only 29.4% reported that patient preference was the
      most important factor in the decision. Physicians were significantly more likely 
      to base decisions on patient preferences when the patient was in the intensive
      care unit (odds ratio (OR)=2.92, 95% confidence interval (CI)=1.15-7.45) and less
      likely when the patient was older (OR=0.76 for each decade of age, 95%
      CI=0.58-0.99). The presence of a living will, prior discussions with the patient,
      and the physicians' beliefs about ethical guidelines did not significantly
      predict the physicians' reliance on patient preferences. CONCLUSION: Although a
      majority of physicians identified patient preferences as the most important
      general ethical guideline for surrogate decision-making, they relied on a variety
      of factors when making treatment decisions for a patient lacking decisional
      capacity.
FAU - Torke, Alexia M
AU  - Torke AM
AD  - Indiana University Center for Aging Research, Indianapolis, Indiana, USA.
      atorke@iupui.edu
FAU - Moloney, Rachael
AU  - Moloney R
FAU - Siegler, Mark
AU  - Siegler M
FAU - Abalos, Anna
AU  - Abalos A
FAU - Alexander, G Caleb
AU  - Alexander GC
LA  - eng
GR  - K08 HS015699/HS/AHRQ HHS/United States
GR  - K23 AG031323/AG/NIA NIH HHS/United States
GR  - K08 HS15699-01A1/HS/AHRQ HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20100211
PL  - United States
TA  - J Am Geriatr Soc
JT  - Journal of the American Geriatrics Society
JID - 7503062
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Advance Directive Adherence
MH  - Aged
MH  - Aged, 80 and over
MH  - Cross-Sectional Studies
MH  - Decision Making/*ethics
MH  - Female
MH  - Health Care Surveys
MH  - Humans
MH  - *Legal Guardians
MH  - Living Wills
MH  - Male
MH  - Middle Aged
MH  - Midwestern United States
MH  - Multivariate Analysis
MH  - *Patient Preference
MH  - *Practice Patterns, Physicians'
PMC - PMC3513265
MID - NIHMS375223
EDAT- 2010/02/18 06:00
MHDA- 2010/05/05 06:00
CRDT- 2010/02/18 06:00
PHST- 2010/02/18 06:00 [entrez]
PHST- 2010/02/18 06:00 [pubmed]
PHST- 2010/05/05 06:00 [medline]
AID - JGS2720 [pii]
AID - 10.1111/j.1532-5415.2010.02720.x [doi]
PST - ppublish
SO  - J Am Geriatr Soc. 2010 Mar;58(3):533-8. doi: 10.1111/j.1532-5415.2010.02720.x.
      Epub 2010 Feb 11.


PMID- 20158544
OWN - NLM
STAT- MEDLINE
DCOM- 20100514
LR  - 20220318
IS  - 1440-172X (Electronic)
IS  - 1322-7114 (Linking)
VI  - 16
IP  - 1
DP  - 2010 Feb
TI  - Ethical values in caring encounters on a geriatric ward from the next of kin's
      perspective: an interview study.
PG  - 20-6
LID - 10.1111/j.1440-172X.2009.01805.x [doi]
AB  - The aim of this study was to identify and describe the governing ethical values
      that next of kin experience in interaction with nurses who care for elderly
      patients at a geriatric clinic. Interviews with 14 next of kin were conducted and
      data were analysed by constant comparative analysis. Four categories were
      identified: receiving, showing respect, facilitating participation and showing
      professionalism. These categories formed the basis of the core category: 'Being
      amenable', a concept identified in the next of kin's description of the ethical
      values that they and the elderly patients perceive in the caring encounter. Being
      amenable means that the nurses are guided by ethical values; taking into account 
      the elderly patient and the next of kin. Nurses' focusing on elderly patients'
      well-being as a final criterion affects the next of kin and their experience of
      this fundamental condition for high-quality care seems to be fulfilled.
FAU - Jonasson, Lise-Lotte
AU  - Jonasson LL
AD  - Department of Nursing Science, School of Health Sciences, University of
      Jonkoping, SE-551 11Jonkoping, Sweden. lise-lotte.jonasson@hhj.hj.se
FAU - Liss, Per-Erik
AU  - Liss PE
FAU - Westerlind, Bjorn
AU  - Westerlind B
FAU - Bertero, Carina
AU  - Bertero C
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Int J Nurs Pract
JT  - International journal of nursing practice
JID - 9613615
MH  - Adult
MH  - Aged
MH  - Attitude of Health Personnel
MH  - *Attitude to Health
MH  - Communication
MH  - Cooperative Behavior
MH  - *Empathy
MH  - Family/*psychology
MH  - Geriatric Nursing/*ethics/organization & administration
MH  - Humans
MH  - Middle Aged
MH  - Models, Nursing
MH  - Nurse's Role/psychology
MH  - Nurse-Patient Relations/ethics
MH  - Nursing Methodology Research
MH  - Nursing Staff/*ethics/organization & administration/psychology
MH  - Principle-Based Ethics
MH  - Professional Competence
MH  - Professional-Family Relations/*ethics
MH  - Qualitative Research
MH  - Surveys and Questionnaires
MH  - Sweden
EDAT- 2010/02/18 06:00
MHDA- 2010/05/15 06:00
CRDT- 2010/02/18 06:00
PHST- 2010/02/18 06:00 [entrez]
PHST- 2010/02/18 06:00 [pubmed]
PHST- 2010/05/15 06:00 [medline]
AID - IJN1805 [pii]
AID - 10.1111/j.1440-172X.2009.01805.x [doi]
PST - ppublish
SO  - Int J Nurs Pract. 2010 Feb;16(1):20-6. doi: 10.1111/j.1440-172X.2009.01805.x.


PMID- 20158288
OWN - NLM
STAT- MEDLINE
DCOM- 20100423
LR  - 20211020
IS  - 1179-1942 (Electronic)
IS  - 0114-5916 (Linking)
VI  - 33
IP  - 3
DP  - 2010 Mar 1
TI  - 'First, do no harm': factors that influence pharmacists making decisions about
      over-the-counter medication: a qualitative study in Northern Ireland.
PG  - 245-55
LID - 10.2165/11319050-000000000-00000 [doi]
AB  - BACKGROUND: Little is known about how community pharmacists make decisions about 
      which over-the-counter (OTC) medication to supply to a patient and the role of
      clinical evidence in making those decisions. OBJECTIVE: To explore factors that
      influence product selection by the pharmacist and the role of evidence-based
      practice in this decision. METHODS: In this qualitative study, community
      pharmacists registered in Northern Ireland and recruited via advertising and
      various qualitative sampling techniques, participated in face-to-face,
      semi-structured interviews (June 2007-September 2007) to discuss issues around
      OTC medication, including the use of evidence, how they judged a product to be
      effective, and their views on evidence-based medicine and its application to OTC 
      medication. All interviews were digitally recorded, fully transcribed and
      analysed using the principles of constant comparison. RESULTS: Twenty-six
      pharmacists participated in interviews. Safety was the over-arching consideration
      for pharmacists when making decisions. The subordinate themes were product,
      patient and professional factors. In terms of the product subordinate theme, use 
      or consideration of evidence was secondary in the selection of OTC medicines.
      Pharmacists considered the potential for harm in the first instance and if the
      product was deemed safe, although lacking any evidence for effectiveness, the
      product was supplied. In relation to patient factors, it emerged that pharmacists
      were influenced by patient demand for a particular OTC product and wanted to meet
      patient expectations, provided that the requested product was judged to be safe. 
      Similarly, professional factors such as ethical considerations (primarily in
      relation to safety) and respecting patient choice also influenced decision
      making. However, pharmacists recognized the conflict between professional
      requirements to practise according to evidence-based principles and patient
      demands. CONCLUSION: This study suggests that pharmacists considered safety above
      all other factors when recommending OTC products to patients, and evidence of
      effectiveness was seldom considered when selling OTC medicines. If evidence-based
      practice is to influence this type of decision, pharmacists need to use the
      evidence that is available and be prepared to discuss evidence with patients.
FAU - Hanna, Lezley-Anne
AU  - Hanna LA
AD  - School of Pharmacy, Queen's University Belfast, Belfast, Northern Ireland.
FAU - Hughes, Carmel M
AU  - Hughes CM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - New Zealand
TA  - Drug Saf
JT  - Drug safety
JID - 9002928
RN  - 0 (Nonprescription Drugs)
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Attitude of Health Personnel/ethnology
MH  - Community Pharmacy Services/*legislation & jurisprudence
MH  - Decision Making/*ethics
MH  - Decision Making, Organizational
MH  - Drug-Related Side Effects and Adverse Reactions
MH  - Evidence-Based Medicine/*standards
MH  - Humans
MH  - Nonprescription Drugs/*pharmacology
MH  - Northern Ireland
MH  - Patient Compliance/psychology
MH  - Pharmaceutical Preparations/analysis
MH  - Pharmacists/*psychology
MH  - Professional-Patient Relations/ethics
MH  - Safety
MH  - Self Medication/adverse effects/*psychology
EDAT- 2010/02/18 06:00
MHDA- 2010/04/24 06:00
CRDT- 2010/02/18 06:00
PHST- 2010/02/18 06:00 [entrez]
PHST- 2010/02/18 06:00 [pubmed]
PHST- 2010/04/24 06:00 [medline]
AID - 6 [pii]
AID - 10.2165/11319050-000000000-00000 [doi]
PST - ppublish
SO  - Drug Saf. 2010 Mar 1;33(3):245-55. doi: 10.2165/11319050-000000000-00000.


PMID- 20158136
OWN - NLM
STAT- MEDLINE
DCOM- 20100324
LR  - 20190608
IS  - 0027-9684 (Print)
IS  - 0027-9684 (Linking)
VI  - 102
IP  - 1
DP  - 2010 Jan
TI  - Ethical concerns about an organ market.
PG  - 46-50
FAU - Demme, Richard A
AU  - Demme RA
AD  - University of Rochester Medical Center, Center for Ethics, Humanities, and
      Palliative Care, 601 Elmwood Ave, Box 675, Rochester, NY 14642, USA.
      richard_demme@urmc.rochester.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Natl Med Assoc
JT  - Journal of the National Medical Association
JID - 7503090
SB  - IM
MH  - *Ethics, Medical
MH  - Humans
MH  - Kidney Transplantation/*economics/*ethics
MH  - Living Donors/*ethics/statistics & numerical data
MH  - *Motivation/ethics
MH  - Poverty
MH  - Socioeconomic Factors
MH  - United States
EDAT- 2010/02/18 06:00
MHDA- 2010/03/25 06:00
CRDT- 2010/02/18 06:00
PHST- 2010/02/18 06:00 [entrez]
PHST- 2010/02/18 06:00 [pubmed]
PHST- 2010/03/25 06:00 [medline]
AID - S0027-9684(15)30477-6 [pii]
AID - 10.1016/s0027-9684(15)30477-6 [doi]
PST - ppublish
SO  - J Natl Med Assoc. 2010 Jan;102(1):46-50. doi: 10.1016/s0027-9684(15)30477-6.


PMID- 20157827
OWN - NLM
STAT- MEDLINE
DCOM- 20100428
LR  - 20211203
IS  - 1432-1203 (Electronic)
IS  - 0340-6717 (Linking)
VI  - 127
IP  - 5
DP  - 2010 Mar
TI  - Population description and its role in the interpretation of genetic association.
PG  - 563-72
LID - 10.1007/s00439-010-0800-0 [doi]
AB  - Despite calls for greater clarity and precision of population description,
      studies have documented persistent ambiguity in the use of race/ethnicity terms
      in genetic research. It is unclear why investigators tolerate such ambiguity, or 
      what effect these practices have on the evaluation of reported associations. To
      explore the way that population description is used to replicate and/or extend
      previously reported genetic observations, we examined articles describing the
      association of the peroxisome proliferator-activated receptor-gamma-gamma
      Pro12Ala polymorphism with type 2 diabetes mellitus and related phenotypes,
      published between 1997 and 2005. The 80 articles identified were subjected to a
      detailed content analysis to determine (1) how sampled populations were
      described, (2) whether and how the choice of sample was explained, and (3) how
      the allele frequency and genetic association findings identified were
      contextualized and interpreted. In common with previous reports, we observed a
      variety of sample descriptions and little explanation for the choice of
      population investigated. Samples of European origin were typically described with
      greater specificity than samples of other origin. However, findings from European
      samples were nearly always compared to samples described as "Caucasian" and
      sometimes generalized to all Caucasians or to all humans. These findings suggest 
      that care with population description, while important, may not fully address
      analytical concerns regarding the interpretation of variable study outcomes or
      ethical concerns regarding the attribution of genetic observations to broad
      social groups. Instead, criteria which help investigators better distinguish
      justified and unjustified forms of population generalization may be required.
FAU - Fullerton, Stephanie M
AU  - Fullerton SM
AD  - Department of Bioethics and Humanities, Center for Genomics and Healthcare
      Equality, University of Washington School of Medicine, Box 357120, Seattle, WA
      98195, USA. smfllrtn@u.washington.edu
FAU - Yu, Joon-Ho
AU  - Yu JH
FAU - Crouch, Julia
AU  - Crouch J
FAU - Fryer-Edwards, Kelly
AU  - Fryer-Edwards K
FAU - Burke, Wylie
AU  - Burke W
LA  - eng
GR  - P50 HG003374/HG/NHGRI NIH HHS/United States
GR  - P50 HG003374-05/HG/NHGRI NIH HHS/United States
GR  - U36 CCU300430-23/PHS HHS/United States
GR  - U10 CCU025038/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20100216
PL  - Germany
TA  - Hum Genet
JT  - Human genetics
JID - 7613873
RN  - 0 (PPAR gamma)
RN  - 9DLQ4CIU6V (Proline)
RN  - OF5P57N2ZX (Alanine)
SB  - IM
MH  - Alanine
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - PPAR gamma/*genetics
MH  - Patient Selection
MH  - *Polymorphism, Single Nucleotide
MH  - Proline
MH  - Racial Groups/*genetics
MH  - Reproducibility of Results
MH  - Validation Studies as Topic
MH  - Whites/genetics
RF  - 30
PMC - PMC2864578
MID - NIHMS195362
EDAT- 2010/02/17 06:00
MHDA- 2010/04/29 06:00
CRDT- 2010/02/17 06:00
PHST- 2009/12/01 00:00 [received]
PHST- 2010/02/04 00:00 [accepted]
PHST- 2010/02/17 06:00 [entrez]
PHST- 2010/02/17 06:00 [pubmed]
PHST- 2010/04/29 06:00 [medline]
AID - 10.1007/s00439-010-0800-0 [doi]
PST - ppublish
SO  - Hum Genet. 2010 Mar;127(5):563-72. doi: 10.1007/s00439-010-0800-0. Epub 2010 Feb 
      16.


PMID- 20156957
OWN - NLM
STAT- MEDLINE
DCOM- 20100520
LR  - 20211020
IS  - 1740-7753 (Electronic)
IS  - 1740-7745 (Linking)
VI  - 7
IP  - 1
DP  - 2010 Feb
TI  - Principles for defining adverse events in behavioral intervention research:
      lessons from a family-focused adolescent drug abuse trial.
PG  - 58-68
LID - 10.1177/1740774509356575 [doi]
AB  - BACKGROUND: Behavioral intervention research has lagged behind biomedical
      research in developing principles for defining, categorizing, identifying,
      reporting, and monitoring adverse events and unanticipated problems. PURPOSE: In 
      this article we present a set of principles for defining adverse events and how
      they were applied in a large national multi-site family therapy study for
      substance-using adolescents, The Brief Strategic Family Therapy (BSFT)
      Effectiveness Study. METHODS: The BSFT Effectiveness study tested how BSFT
      compares to Treatment as Usual (TAU) for the treatment of drug-abusing
      adolescents. During protocol development, experts in the BSFT intervention,
      medical safety officers, ethicists and senior investigators defined the
      procedures for identifying, tracking and reporting adverse events for drug using 
      adolescents as well as their family members. During this process the team
      identified five key guiding principles. RESULTS: The five guiding principles that
      were used for defining adverse events in this behavioral trial were that that the
      adverse events should be validated and plausible, and that monitoring systems
      should assess relatedness, be systematic, and are a shared responsibility. The
      following non-serious adverse events were identified: arrest, school suspension
      and drop out, runaway, kicked out of home and violence. The serious adverse
      events in this study for the identified adolescent participant and all other
      consented family members were physical or sexual abuse, suicidal behavior,
      homicidal behavior, hospitalization (drug related or psychiatric related only)
      and death. The methods used in categorizing, identifying and reporting adverse
      events in the BSFT trial are outlined. More than 50% of the adolescent population
      (277/481 = 57.5 %) experienced an adverse event during the trial. Family members 
      experienced less adverse events, (61/1338 = 4.5%). The most common event for the 
      adolescent group was arrest (164/277= 59.2%), followed by school
      suspension/dropout (143/277 = 51.6%), and runaway (79/277= 28.5 %). For the
      family member group, the most common event was violence (25/ 61 = 40.9%) followed
      by arrest (13/61 = 21.3%). There was a significant difference in the presence of 
      adverse events in family members that were randomized to BSFT 44/721 (6.1%) when 
      compared to Treatment as Usual 17/617 (2.8%) (p = 0.004). A probable explanation 
      for this is that there were more opportunities to identify adverse events for
      family members assigned to BSFT because family members attended therapy sessions.
      This difference may also represent the risk for family members that participate
      in an evidence-based family intervention like BSFT. LIMITATIONS: The utility of
      the principles outside of the BSFT trial is unknown. CONCLUSIONS: Based on the
      events reported in this trial, the efforts for monitoring and categorizing
      adverse events appeared justified and appropriate. The strategies and principles 
      described in this paper may be useful for those developing safety plans for
      behavioral intervention research, and to family therapy researchers for assessing
      the safety of behavioral family interventions.
FAU - Horigian, Viviana E
AU  - Horigian VE
AD  - Center for Family Studies, University of Miami, Miami, FL 33155, USA.
      vhorigian@med.miami.edu
FAU - Robbins, Michael S
AU  - Robbins MS
FAU - Dominguez, Roberto
AU  - Dominguez R
FAU - Ucha, Jessica
AU  - Ucha J
FAU - Rosa, Carmen L
AU  - Rosa CL
LA  - eng
GR  - U10 DA013720/DA/NIDA NIH HHS/United States
GR  - U10 DA013720-10/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Trials
JT  - Clinical trials (London, England)
JID - 101197451
SB  - IM
MH  - Adolescent
MH  - Adolescent Behavior/psychology
MH  - *Behavior Therapy
MH  - *Behavioral Research
MH  - Conduct Disorder/*classification
MH  - Family Therapy/*methods
MH  - Humans
MH  - Multicenter Studies as Topic
MH  - Substance-Related Disorders/physiopathology/*psychology
PMC - PMC3163837
MID - NIHMS317104
EDAT- 2010/02/17 06:00
MHDA- 2010/05/21 06:00
CRDT- 2010/02/17 06:00
PHST- 2010/02/17 06:00 [entrez]
PHST- 2010/02/17 06:00 [pubmed]
PHST- 2010/05/21 06:00 [medline]
AID - 7/1/58 [pii]
AID - 10.1177/1740774509356575 [doi]
PST - ppublish
SO  - Clin Trials. 2010 Feb;7(1):58-68. doi: 10.1177/1740774509356575.


PMID- 20156482
OWN - NLM
STAT- MEDLINE
DCOM- 20100709
LR  - 20131121
IS  - 1879-016X (Electronic)
IS  - 0163-7258 (Linking)
VI  - 126
IP  - 2
DP  - 2010 May
TI  - Impacts of recent advances in cardiovascular regenerative medicine on clinical
      therapies and drug discovery.
PG  - 109-18
LID - 10.1016/j.pharmthera.2010.01.010 [doi]
AB  - Although stem-cell technology holds great promise for the treatment of
      degenerative diseases and the development of new drugs, progress has been
      hindered by immune and ethical problems in association with the use of embryonic 
      stem cells (ESCs). The recent development of reprogramming of differentiated
      human somatic cells to pluripotent stem cells (iPSCs) should overcome these
      obstacles and facilitate clinical applications of stem cells. One of the
      advantages of reprogramming is that it allows the establishment of patient- and
      disease-specific in vitro models of human hereditary diseases for
      pathophysiologic and developmental studies. These in vitro models can be used for
      drug development and testing, moving us a step closer to personalized therapies. 
      This review outlines the current status of pluripotent stem cells and focuses on 
      the potential applications of stem cell-derived cardiomyocytes for clinical
      therapies, as well as for drug development and testing.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Murata, Mitsushige
AU  - Murata M
AD  - Department of Regenerative Medicine and Advanced Cardiac Therapeutics, School of 
      Medicine, Keio University, Tokyo, Japan.
FAU - Tohyama, Shugo
AU  - Tohyama S
FAU - Fukuda, Keiichi
AU  - Fukuda K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100213
PL  - England
TA  - Pharmacol Ther
JT  - Pharmacology & therapeutics
JID - 7905840
SB  - IM
MH  - Animals
MH  - Cardiovascular Diseases/genetics/metabolism/*therapy
MH  - Cell Differentiation
MH  - Disease Models, Animal
MH  - Drug Discovery/*methods/trends
MH  - Drug-Related Side Effects and Adverse Reactions
MH  - Electrophysiological Phenomena
MH  - Humans
MH  - Myocytes, Cardiac/*cytology/metabolism
MH  - Pluripotent Stem Cells/cytology/drug effects/*transplantation
MH  - Regenerative Medicine/*methods/trends
RF  - 122
EDAT- 2010/02/17 06:00
MHDA- 2010/07/10 06:00
CRDT- 2010/02/17 06:00
PHST- 2010/01/16 00:00 [received]
PHST- 2010/01/19 00:00 [accepted]
PHST- 2010/02/17 06:00 [entrez]
PHST- 2010/02/17 06:00 [pubmed]
PHST- 2010/07/10 06:00 [medline]
AID - S0163-7258(10)00027-6 [pii]
AID - 10.1016/j.pharmthera.2010.01.010 [doi]
PST - ppublish
SO  - Pharmacol Ther. 2010 May;126(2):109-18. doi: 10.1016/j.pharmthera.2010.01.010.
      Epub 2010 Feb 13.


PMID- 20156176
OWN - NLM
STAT- MEDLINE
DCOM- 20100806
LR  - 20191111
IS  - 2212-4039 (Electronic)
IS  - 1872-2113 (Linking)
VI  - 4
IP  - 2
DP  - 2010 Jun
TI  - Recents patents for isolating, delivering and tracking adult stem cells in
      regenerative medicine.
PG  - 105-13
AB  - The field of regenerative medicine offers nowadays the potential to significantly
      impact a wide spectrum of healthcare issues, from insulin-dependent diabetes
      mellitus (Type 1 diabetes, T1D) to cardiovascular disease. In tissue engineering 
      biomaterials, biological factors, regeneration competent cells are used in the
      process of creating functional tissue. Regarding the type of stem or progenitor
      cells which represents the best candidate for therapy, embryonic stem cells have 
      been considered the master cells capable of differentiating into every type of
      cells either in vitro or in vivo, in spite of serious ethical concerns.
      Nevertheless experimental evidence suggests that adult stem cells and even
      terminally differentiated somatic cells under appropriate microenvironmental
      treatments can be reprogrammed and contribute to a much wider spectrum of
      differentiated progeny than previously anticipated. One of the main goals is to
      exploit novel technologies aiming to isolate, expand and enrich sources of
      regeneration competent cells, especially adult somatic stem cells. Researchers
      are also trying to develop innovative strategies for effectively delivering
      regenerative cell populations and to implement 'tracking' tools to verify their
      engraftment and destiny in vivo. Here we review recent patents on the field
      issued over the past five years.
FAU - Fierabracci, Alessandra
AU  - Fierabracci A
AD  - Autoimmunity and Organ Regeneration Laboratory, Ospedale Pediatrico Bambino Gesu'
      Research Institute, Rome, Italy. fierabracci@opbg.net
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Recent Pat Drug Deliv Formul
JT  - Recent patents on drug delivery & formulation
JID - 101462399
SB  - IM
MH  - Adult Stem Cells/metabolism/*transplantation
MH  - Animals
MH  - Cell Differentiation/physiology
MH  - Embryonic Stem Cells/metabolism/transplantation
MH  - Humans
MH  - Patents as Topic
MH  - Regenerative Medicine/*methods
MH  - Stem Cell Transplantation/*methods
MH  - Tissue Engineering/methods
RF  - 68
EDAT- 2010/02/17 06:00
MHDA- 2010/08/07 06:00
CRDT- 2010/02/17 06:00
PHST- 2009/12/02 00:00 [received]
PHST- 2009/01/14 00:00 [accepted]
PHST- 2010/02/17 06:00 [entrez]
PHST- 2010/02/17 06:00 [pubmed]
PHST- 2010/08/07 06:00 [medline]
AID - BSP/DDF/EPUB/00003 [pii]
AID - 10.2174/187221110791184980 [doi]
PST - ppublish
SO  - Recent Pat Drug Deliv Formul. 2010 Jun;4(2):105-13. doi:
      10.2174/187221110791184980.


PMID- 20156108
OWN - NLM
STAT- MEDLINE
DCOM- 20100421
LR  - 20100216
IS  - 1931-8405 (Electronic)
IS  - 0889-2229 (Linking)
VI  - 26
IP  - 2
DP  - 2010 Feb
TI  - Pediatric HIV BioBank: a new role of the Spanish HIV BioBank in pediatric HIV
      research.
PG  - 241-4
LID - 10.1089/aid.2009.0122 [doi]
AB  - The vulnerability of children has long raised ethical concerns resulting in the
      lack of inclusion of children in research studies. This has impeded the
      development of relevant medical therapies specific for children. In response to
      these circumstances, international policies have begun to recognize the need to
      carry out research focused on children. Translational HIV infection research is
      highly dependent on many factors including the availability, quality, and
      traceability of samples and their associated data under a strict system of
      quality management. The primary objective of the Pediatric HIV BioBank is to
      contribute to the furthering of scientific knowledge about vertical HIV
      infection. To achieve this aim, the BioBank processes, stores, and provides
      distinct samples from HIV/AIDS children to research projects free of charge.
      Strict compliance to ethical norms is always guaranteed. At present the Pediatric
      HIV BioBank has 429 vials containing different sample types from 243 vertically
      HIV-infected children. The Pediatric HIV BioBank represents a novel approach to
      HIV research that might be of general interest not only for basic and clinical
      research teams working with HIV, but also for those groups trying to establish
      large networks focused on researching specific clinical problems. It also
      represents a model to stimulate cooperative research on specific clinical
      problems. The main objective of this article is to show the structure and
      function of the Pediatric HIV BioBank that allow it to efficiently provide
      samples to different research projects in Spain and in other countries.
FAU - Garcia-Merino, Isabel
AU  - Garcia-Merino I
AD  - Laboratorio de Inmunobiologia Molecular, Hospital General Universitario Gregorio 
      Maranon, Madrid , Spain.
FAU - de Las Cuevas, Natividad
AU  - de Las Cuevas N
FAU - Jimenez, Jose Luis
AU  - Jimenez JL
FAU - Garcia, Almudena
AU  - Garcia A
FAU - Gallego, Jorge
AU  - Gallego J
FAU - Gomez, Coral
AU  - Gomez C
FAU - Garcia, Dolores
AU  - Garcia D
FAU - Munoz-Fernandez, Ma Angeles
AU  - Munoz-Fernandez MA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - AIDS Res Hum Retroviruses
JT  - AIDS research and human retroviruses
JID - 8709376
SB  - IM
MH  - *Biological Specimen Banks
MH  - Biomedical Research/*methods
MH  - Child
MH  - Child, Preschool
MH  - HIV Infections/*virology
MH  - Humans
MH  - Spain
EDAT- 2010/02/17 06:00
MHDA- 2010/04/22 06:00
CRDT- 2010/02/17 06:00
PHST- 2010/02/17 06:00 [entrez]
PHST- 2010/02/17 06:00 [pubmed]
PHST- 2010/04/22 06:00 [medline]
AID - 10.1089/aid.2009.0122 [doi]
PST - ppublish
SO  - AIDS Res Hum Retroviruses. 2010 Feb;26(2):241-4. doi: 10.1089/aid.2009.0122.


PMID- 20155643
OWN - NLM
STAT- MEDLINE
DCOM- 20100504
LR  - 20100215
IS  - 1439-1074 (Electronic)
IS  - 0939-2661 (Linking)
VI  - 45
IP  - 2
DP  - 2010 Feb
TI  - [Economy and ethics in daily hospital routine - physicians in conflict between
      the well-being of patients and profitability].
PG  - 128-31
LID - 10.1055/s-0030-1248148 [doi]
AB  - Medical decision making is affected by different aims and influencing factors.
      Nowadays economic aspects are so important that they influence the structure of
      hospitals, the number and quality of personnel, and the treatment and care of
      patients. This leads to conflicts with moral aims, especially when the necessary 
      service cannot be provided due to financial reasons or when doubtful offers are
      supposed to increase revenues. Examples demonstrate cases in which economic
      aspects become more important than patients' interests because physicians are
      corruptible. It is necessary to communicate values. Patients' health should be
      first and economy should be a subordinated service.
CI  - Georg Thieme Verlag Stuttgart * New York.
FAU - Salomon, Fred
AU  - Salomon F
AD  - Klinik fur Anasthesiologie und Operative Intensivmedizin am Klinikum Lippe-Lemgo.
      fred.salomon@klinikum-lippe.de
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Okonomie und Ethik im Klinikalltag - Der Arzt im Spannungsfeld zwischen
      Patientenwohl und Wirtschaftlichkeit.
DEP - 20100212
PL  - Germany
TA  - Anasthesiol Intensivmed Notfallmed Schmerzther
JT  - Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS
JID - 9109478
SB  - IM
MH  - Decision Making
MH  - Economics, Hospital/*ethics
MH  - Health Care Rationing
MH  - Health Priorities
MH  - Humans
MH  - *Morals
MH  - Physician-Patient Relations
MH  - *Physicians
MH  - Research
MH  - Risk Assessment
RF  - 18
EDAT- 2010/02/16 06:00
MHDA- 2010/05/05 06:00
CRDT- 2010/02/16 06:00
PHST- 2010/02/16 06:00 [entrez]
PHST- 2010/02/16 06:00 [pubmed]
PHST- 2010/05/05 06:00 [medline]
AID - 10.1055/s-0030-1248148 [doi]
PST - ppublish
SO  - Anasthesiol Intensivmed Notfallmed Schmerzther. 2010 Feb;45(2):128-31. doi:
      10.1055/s-0030-1248148. Epub 2010 Feb 12.


PMID- 20155496
OWN - NLM
STAT- MEDLINE
DCOM- 20100713
LR  - 20211020
IS  - 1435-2451 (Electronic)
IS  - 1435-2443 (Linking)
VI  - 395
IP  - 4
DP  - 2010 Apr
TI  - Minimally invasive video-assisted thyroidectomy (MIVAT): what is the real
      advantage?
PG  - 323-6
LID - 10.1007/s00423-009-0589-2 [doi]
AB  - BACKGROUND: The evolution of video-assisted or laparoscopic surgical techniques
      in the last several years has changed the surgical treatment approach to many
      diseases, also in endocrine surgery. MATERIALS AND METHODS: From July 2005 to
      March 2009, we treated 211 patients with minimally invasive video-assisted
      thyroidectomy (MIVAT). The procedure was performed in accordance with Miccoli's
      technique using an Ultracision CS 14 (Ethicon Endosurgery) and/or Single Use
      Automatic Clip Applier S-90 (Autosuture). In all cases, we recorded the incidence
      of postoperative hypocalcaemia as a serum calcium value lower than 8 mg/dl with
      or without hypocalcaemic symptoms, postoperative haemorrhage or nerve palsy, mean
      operative time. All patients were also assessed for postoperative pain and given 
      a visual analogue score from 0 to 10 at 1 and 24 h after surgery. We matched
      these results with a group of 587 patients treated during the same period with
      traditional thyroidectomy. RESULTS: The female/male ratio was 4:1; the mean age
      of the patients was 50.6 years. In the MIVAT group, the mean time of surgical
      procedure decreased by 52.4 min. We observed 16 hypocalcaemic cases with clinical
      symptoms (7.58%) (six of these cases were published in a previous article and
      were among the first 100 cases treated) and 59 cases of serologic hypocalcaemia
      (27.9%) (serum calcium lower than 8 mg/dl); the mean value of calcium
      concentration was 7.5 +/- 0.27 mg/dl. We observed six cases of monolateral nerve 
      palsy, and after 6 months, a definitive palsy in two cases (0.9%); these two
      cases were in the first 25 cases treated. Comparisons with traditional
      thyroidectomy group showed statistically significant differences in postoperative
      serologic hypocalcaemia (p < 0.001), no difference in mean calcium value (p =
      0.41) and no statistical difference in the incidences of nerve palsy and
      haemorrhage. CONCLUSIONS: Patients treated with MIVAT showed an improvement in
      incidence of postoperative hypocalcaemia, postoperative pain, postoperative stay,
      psychophysical recovery and cosmetic result.
FAU - Del Rio, Paolo
AU  - Del Rio P
AD  - Department of Surgical Science, Unit of General Surgery and Organ
      Transplantation, University Hospital of Parma, Via Gramsci 14, 43100, Parma,
      Italy. paolo.delrio@unipr.it
FAU - Arcuri, Maria Francesca
AU  - Arcuri MF
FAU - Pisani, Paola
AU  - Pisani P
FAU - De Simone, Belinda
AU  - De Simone B
FAU - Sianesi, Mario
AU  - Sianesi M
LA  - eng
PT  - Journal Article
DEP - 20100216
PL  - Germany
TA  - Langenbecks Arch Surg
JT  - Langenbeck's archives of surgery
JID - 9808285
SB  - IM
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Minimally Invasive Surgical Procedures
MH  - Thyroid Diseases/*surgery
MH  - Thyroidectomy/adverse effects/*methods
MH  - Video-Assisted Surgery
EDAT- 2010/02/16 06:00
MHDA- 2010/07/14 06:00
CRDT- 2010/02/16 06:00
PHST- 2009/11/16 00:00 [received]
PHST- 2009/12/22 00:00 [accepted]
PHST- 2010/02/16 06:00 [entrez]
PHST- 2010/02/16 06:00 [pubmed]
PHST- 2010/07/14 06:00 [medline]
AID - 10.1007/s00423-009-0589-2 [doi]
PST - ppublish
SO  - Langenbecks Arch Surg. 2010 Apr;395(4):323-6. doi: 10.1007/s00423-009-0589-2.
      Epub 2010 Feb 16.


PMID- 20155398
OWN - NLM
STAT- MEDLINE
DCOM- 20100621
LR  - 20211020
IS  - 1572-8633 (Electronic)
IS  - 1386-7423 (Linking)
VI  - 13
IP  - 2
DP  - 2010 May
TI  - Choosing for the child with cochlear implants: a note of precaution.
PG  - 157-67
LID - 10.1007/s11019-010-9232-9 [doi]
AB  - Recent contributions to discussions on paediatric cochlear implantation in Norway
      indicate two mutually exclusive doctrines prescribing the best course of
      post-operative support for a child with cochlear implants; bilingually with sign 
      language and spoken language simultaneously or primarily monolingually with
      speech only. This conflict constitutes an ethical problem for parents responsible
      for choosing between one of the two alternatives. This article puts forth the
      precautionary principle as a possible solution to this problem. Although
      scientific uncertainty exists in the case of both doctrines, there exists a
      scenario of possible irreversible harm to some of the children habilitated
      monolingually. An application of the precautionary principle may hence suggest
      that it is rational to agree on the bilingual approach, at least for the
      time-being.
FAU - Kermit, Patrick
AU  - Kermit P
AD  - Department of Social Work and Health Science, Norwegian University of Science and
      Technology, Dragvoll, 7491, Trondheim, Norway. patrick.kermit@svt.ntnu.no
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Med Health Care Philos
JT  - Medicine, health care, and philosophy
JID - 9815900
SB  - IM
MH  - Cochlear Implantation/*ethics/*rehabilitation
MH  - Humans
MH  - Multilingualism
MH  - *Parents
MH  - Sign Language
MH  - Speech
MH  - Uncertainty
EDAT- 2010/02/16 06:00
MHDA- 2010/06/22 06:00
CRDT- 2010/02/16 06:00
PHST- 2010/02/16 06:00 [entrez]
PHST- 2010/02/16 06:00 [pubmed]
PHST- 2010/06/22 06:00 [medline]
AID - 10.1007/s11019-010-9232-9 [doi]
PST - ppublish
SO  - Med Health Care Philos. 2010 May;13(2):157-67. doi: 10.1007/s11019-010-9232-9.


PMID- 20154621
OWN - NLM
STAT- MEDLINE
DCOM- 20100617
LR  - 20171116
IS  - 1531-7013 (Electronic)
IS  - 1087-2418 (Linking)
VI  - 15
IP  - 2
DP  - 2010 Apr
TI  - Denial of hepatic transplantation on the basis of smoking: is it ethical?
PG  - 249-53
LID - 10.1097/MOT.0b013e3283373551 [doi]
AB  - PURPOSE OF REVIEW: There is disagreement and inconsistency between liver
      transplant programs regarding the acceptance or rejection of smokers as
      candidates for transplantation. This article reviews the outcome data for
      transplanted smokers, the rate of maintained abstinence from cigarettes by
      smokers who have quit and the ethics of using tobacco use as a transplant
      selection criterion. RECENT FINDINGS: Consistent with earlier studies, recently
      published articles continue to demonstrate an increased risk of noncutaneous
      malignancies, higher rates of graft arterial thrombosis and a higher mortality
      rate in liver transplant patients who smoke as compared with nonsmokers. There is
      a significant rate of relapse to smoking after transplantation, and the rates are
      higher among patients with alcoholic liver disease. Recent studies have shown
      that 10-16% of patients with biochemical verification of active smoking deny
      their tobacco use when interviewed for transplant consideration. Although
      extensively, if not universally, used to exclude transplant candidates, a recent 
      study of marijuana use showed no difference in mortality outcomes as compared
      with nonusers. SUMMARY: With the exception of one recent study, there is
      substantial literature to support increased morbidity and mortality among
      posthepatic transplant smokers.
FAU - Bright, Robert P
AU  - Bright RP
AD  - Department of Psychiatry and Psychology, Mayo Clinic, Scottsdale, Arizona 85259, 
      USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Organ Transplant
JT  - Current opinion in organ transplantation
JID - 9717388
SB  - IM
MH  - Attitude of Health Personnel
MH  - Evidence-Based Medicine
MH  - Graft Rejection/etiology
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Liver Transplantation/adverse effects/*ethics/mortality/psychology
MH  - Marijuana Abuse/complications
MH  - Neoplasms/etiology
MH  - *Patient Compliance/psychology
MH  - Patient Education as Topic
MH  - Patient Selection/*ethics
MH  - Recurrence
MH  - Refusal to Treat/*ethics
MH  - Risk Assessment
MH  - Risk Factors
MH  - Smoking/*adverse effects/mortality/psychology
MH  - *Smoking Cessation/psychology
MH  - Smoking Prevention
MH  - Treatment Outcome
RF  - 29
EDAT- 2010/02/16 06:00
MHDA- 2010/06/18 06:00
CRDT- 2010/02/16 06:00
PHST- 2010/02/16 06:00 [entrez]
PHST- 2010/02/16 06:00 [pubmed]
PHST- 2010/06/18 06:00 [medline]
AID - 10.1097/MOT.0b013e3283373551 [doi]
PST - ppublish
SO  - Curr Opin Organ Transplant. 2010 Apr;15(2):249-53. doi:
      10.1097/MOT.0b013e3283373551.


PMID- 20154523
OWN - NLM
STAT- MEDLINE
DCOM- 20100430
LR  - 20100215
IS  - 1550-5014 (Electronic)
IS  - 0161-9268 (Linking)
VI  - 33
IP  - 1
DP  - 2010 Jan-Mar
TI  - The stewardship model: current viability for genetic biobank practice
      development.
PG  - E41-9
LID - 10.1097/ANS.0b013e3181cd8367 [doi]
AB  - The "stewardship model" of ethics relationships is a conceptual framework
      initially proposed by Jeffers in Advances in Nursing Science, 24(2), 2001. It
      conceptualized ethical responsibilities in the practice of systematic collection 
      and storage of biospecimens in biobanks for future healthcare genetic research.
      Since the article's publication 8 years ago, genetic biobanks have grown in
      number around the world and discernible biobank relational conceptualizations
      were published. Nursing leadership adopted competency standards for all genetic
      nursing practices. The involvement of nurses has increased and is projected for
      further significant increase as biobank practices emerge from research into
      clinical care settings. This assessment of current viability of this previously
      established stewardship model offers fresh insights to existing and future
      nursing research and practice. The purpose of this article was to analyze the
      original stewardship model's components, the relational parties, and
      characteristics; by contrasting those with proposed conceptualizations and
      existing biobank practices developed subsequent to its publication. The model's
      current viability and theoretical development status are assessed for its ability
      to support a future nursing evidence base for best practices. Proposals for the
      model's expansion are suggested.
FAU - Williams, Pamela Holtzclaw
AU  - Williams PH
AD  - University of Washington School of Nursing, Seattle, USA. phwillia@unc.edu
FAU - Schepp, Karen
AU  - Schepp K
FAU - McGrath, Barbara
AU  - McGrath B
FAU - Mitchell, Pamela
AU  - Mitchell P
LA  - eng
GR  - T32/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - ANS Adv Nurs Sci
JT  - ANS. Advances in nursing science
JID - 7809992
SB  - IM
MH  - Altruism
MH  - Attitude to Health
MH  - Benchmarking
MH  - Biological Specimen Banks/ethics/*organization & administration
MH  - Cooperative Behavior
MH  - *Databases, Genetic/ethics
MH  - Evidence-Based Nursing/education/organization & administration
MH  - Genetic Research/ethics
MH  - Humans
MH  - Mass Media/ethics
MH  - *Models, Nursing
MH  - Motivation
MH  - *Nurse's Role
MH  - Nurse-Patient Relations/ethics
MH  - Patient Advocacy/ethics
MH  - Professional Competence
MH  - Researcher-Subject Relations/ethics
MH  - Trust
EDAT- 2010/02/16 06:00
MHDA- 2010/05/01 06:00
CRDT- 2010/02/16 06:00
PHST- 2010/02/16 06:00 [entrez]
PHST- 2010/02/16 06:00 [pubmed]
PHST- 2010/05/01 06:00 [medline]
AID - 10.1097/ANS.0b013e3181cd8367 [doi]
AID - 00012272-201001000-00012 [pii]
PST - ppublish
SO  - ANS Adv Nurs Sci. 2010 Jan-Mar;33(1):E41-9. doi: 10.1097/ANS.0b013e3181cd8367.


PMID- 20154295
OWN - NLM
STAT- MEDLINE
DCOM- 20100804
LR  - 20220317
IS  - 1049-7323 (Print)
IS  - 1049-7323 (Linking)
VI  - 20
IP  - 5
DP  - 2010 May
TI  - Agency and communication challenges in discussions of informed consent in
      pediatric cancer research.
PG  - 628-43
LID - 10.1177/1049732310361467 [doi]
AB  - In this article we examine the discourse of four focus groups we conducted at a
      pediatric research hospital in which we queried teenage patients, parents,
      nurses, and physicians about their perceptions of the informed consent process in
      research. Autonomy, as the goal of informed consent, is a murky concept, with
      some ethicists questioning the possibility that it can ever be attained. We argue
      that it might be more productive to consider agency, which we define as language 
      and action that are constructed, negotiated, and maintained through effective
      communication. Our goal was to understand how individuals rhetorically
      constructed agency in discussions of informed consent experiences. After
      transcribing and coding the focus group interviews, we identified six aspects of 
      agency in participants' discourse: (a) defining roles, (b) seeking information,
      (c) providing information, (d) supporting others, (e) making decisions, and (f)
      claiming agency for self. Examining these aspects of agency indicated that
      efforts to improve the informed consent process must address: (a) status
      differentials, (b) role definitions, (c) information flow, and (d) relationships.
FAU - Young, Amanda J
AU  - Young AJ
AD  - Department of Communication, 143 Theatre and Communication, University of
      Memphis, Memphis, TN 38152, USA. ajyoung@memphis.edu
FAU - Kim, Loel
AU  - Kim L
FAU - Shu Li
AU  - Shu Li
FAU - Baker, Justin N
AU  - Baker JN
FAU - Schmidt, Michael
AU  - Schmidt M
FAU - Camp, Jonathan W
AU  - Camp JW
FAU - Barfield, Raymond C
AU  - Barfield RC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100212
PL  - United States
TA  - Qual Health Res
JT  - Qualitative health research
JID - 9202144
MH  - Adolescent
MH  - *Communication
MH  - Decision Making
MH  - Female
MH  - Focus Groups
MH  - Humans
MH  - *Informed Consent
MH  - Male
MH  - *Neoplasms
MH  - Nurse-Patient Relations
MH  - *Pediatrics
MH  - Physician-Patient Relations
MH  - *Research
MH  - Tennessee
EDAT- 2010/02/16 06:00
MHDA- 2010/08/05 06:00
CRDT- 2010/02/16 06:00
PHST- 2010/02/16 06:00 [entrez]
PHST- 2010/02/16 06:00 [pubmed]
PHST- 2010/08/05 06:00 [medline]
AID - 1049732310361467 [pii]
AID - 10.1177/1049732310361467 [doi]
PST - ppublish
SO  - Qual Health Res. 2010 May;20(5):628-43. doi: 10.1177/1049732310361467. Epub 2010 
      Feb 12.


PMID- 20154028
OWN - NLM
STAT- MEDLINE
DCOM- 20100617
LR  - 20100215
IS  - 1472-4146 (Electronic)
IS  - 0021-9746 (Linking)
VI  - 63
IP  - 2
DP  - 2010 Feb
TI  - Ethical issues in laboratory medicine.
PG  - 97-8
LID - 10.1136/jcp.2007.054494 [doi]
FAU - Wijeratne, Nishardi
AU  - Wijeratne N
FAU - Benatar, Solomon R
AU  - Benatar SR
LA  - eng
GR  - 1R25 TW06057/TW/FIC NIH HHS/United States
PT  - Editorial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Clin Pathol
JT  - Journal of clinical pathology
JID - 0376601
SB  - IM
MH  - Clinical Competence
MH  - *Ethics, Medical
MH  - Humans
MH  - Laboratories/*ethics/standards
MH  - Pathology, Clinical/*ethics/standards
MH  - Quality of Health Care
EDAT- 2010/02/16 06:00
MHDA- 2010/06/18 06:00
CRDT- 2010/02/16 06:00
PHST- 2010/02/16 06:00 [entrez]
PHST- 2010/02/16 06:00 [pubmed]
PHST- 2010/06/18 06:00 [medline]
AID - 63/2/97 [pii]
AID - 10.1136/jcp.2007.054494 [doi]
PST - ppublish
SO  - J Clin Pathol. 2010 Feb;63(2):97-8. doi: 10.1136/jcp.2007.054494.


PMID- 20153470
OWN - NLM
STAT- MEDLINE
DCOM- 20100416
LR  - 20151119
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 93
IP  - 6
DP  - 2010 Apr
TI  - Surrogate end points in women's health research: science, protoscience, and
      pseudoscience.
PG  - 1731-4
LID - 10.1016/j.fertnstert.2009.12.054 [doi]
AB  - A surrogate end point (e.g., a laboratory test or image) serves as a proxy for a 
      clinical end point of importance (e.g., fracture, thrombosis, or death). Adoption
      and use of surrogate end points lacking validation, especially in cardiovascular 
      medicine, have caused thousands of patients' deaths, a serious violation of the
      ethical principle of beneficence.
CI  - Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier 
      Inc. All rights reserved.
FAU - Grimes, David A
AU  - Grimes DA
FAU - Schulz, Kenneth F
AU  - Schulz KF
FAU - Raymond, Elizabeth G
AU  - Raymond EG
LA  - eng
PT  - Editorial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20100212
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
RN  - 0 (Biomarkers)
SB  - IM
MH  - Biomarkers/*analysis
MH  - Female
MH  - Health Planning Guidelines
MH  - Humans
MH  - Research/*standards/trends
MH  - Research Design
MH  - Science/methods/*standards/trends
MH  - Validation Studies as Topic
MH  - *Women's Health
RF  - 32
EDAT- 2010/02/16 06:00
MHDA- 2010/04/17 06:00
CRDT- 2010/02/16 06:00
PHST- 2009/11/12 00:00 [received]
PHST- 2009/12/21 00:00 [revised]
PHST- 2009/12/22 00:00 [accepted]
PHST- 2010/02/16 06:00 [entrez]
PHST- 2010/02/16 06:00 [pubmed]
PHST- 2010/04/17 06:00 [medline]
AID - S0015-0282(09)04313-1 [pii]
AID - 10.1016/j.fertnstert.2009.12.054 [doi]
PST - ppublish
SO  - Fertil Steril. 2010 Apr;93(6):1731-4. doi: 10.1016/j.fertnstert.2009.12.054. Epub
      2010 Feb 12.


PMID- 20153450
OWN - NLM
STAT- MEDLINE
DCOM- 20110616
LR  - 20161222
IS  - 1556-3871 (Electronic)
IS  - 1547-5271 (Linking)
VI  - 7
IP  - 6
DP  - 2010 Jun
TI  - Understanding ethical issues, ICD, and DNR orders: an obstacle to imminent death?
PG  - 858-60
LID - 10.1016/j.hrthm.2010.02.009 [doi]
FAU - Mullen, Michelle A
AU  - Mullen MA
AD  - University of Ottawa, Children's Hospital of Eastern Ontario, Ottawa, Ontario,
      Canada. mmullen@cheo.on.ca
FAU - Gow, Robert M
AU  - Gow RM
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20100211
PL  - United States
TA  - Heart Rhythm
JT  - Heart rhythm
JID - 101200317
SB  - IM
MH  - Advance Directives/*ethics
MH  - Aged
MH  - Cardiomyopathy, Dilated/*therapy
MH  - Codes of Ethics
MH  - Defibrillators, Implantable/*ethics
MH  - *Ethics, Medical
MH  - Humans
MH  - Male
MH  - Prognosis
MH  - Resuscitation Orders/*ethics
EDAT- 2010/02/16 06:00
MHDA- 2011/06/17 06:00
CRDT- 2010/02/16 06:00
PHST- 2010/01/18 00:00 [received]
PHST- 2010/02/07 00:00 [accepted]
PHST- 2010/02/16 06:00 [entrez]
PHST- 2010/02/16 06:00 [pubmed]
PHST- 2011/06/17 06:00 [medline]
AID - S1547-5271(10)00114-1 [pii]
AID - 10.1016/j.hrthm.2010.02.009 [doi]
PST - ppublish
SO  - Heart Rhythm. 2010 Jun;7(6):858-60. doi: 10.1016/j.hrthm.2010.02.009. Epub 2010
      Feb 11.


PMID- 20153285
OWN - NLM
STAT- MEDLINE
DCOM- 20100813
LR  - 20100525
IS  - 1873-6254 (Electronic)
IS  - 0001-706X (Linking)
VI  - 115
IP  - 1-2
DP  - 2010 Jul-Aug
TI  - The ethics of improving African traditional medical practice: a response.
PG  - 163-4
LID - 10.1016/j.actatropica.2010.02.006 [doi]
FAU - Willcox, Merlin L
AU  - Willcox ML
FAU - Bodeker, Gerard
AU  - Bodeker G
LA  - eng
PT  - Comment
PT  - Letter
DEP - 20100211
PL  - Netherlands
TA  - Acta Trop
JT  - Acta tropica
JID - 0370374
RN  - 0 (Therapeutic Uses)
SB  - IM
CON - Acta Trop. 2009 Nov;112 Suppl 1:S32-6. PMID: 19682966
MH  - Africa
MH  - Biomedical Research/*ethics
MH  - Ethics
MH  - Humans
MH  - Medicine, African Traditional/*adverse effects/*methods/trends
MH  - Therapeutic Human Experimentation/*ethics
MH  - Therapeutic Uses
EDAT- 2010/02/16 06:00
MHDA- 2010/08/14 06:00
CRDT- 2010/02/16 06:00
PHST- 2010/02/03 00:00 [received]
PHST- 2010/02/05 00:00 [accepted]
PHST- 2010/02/16 06:00 [entrez]
PHST- 2010/02/16 06:00 [pubmed]
PHST- 2010/08/14 06:00 [medline]
AID - S0001-706X(10)00035-5 [pii]
AID - 10.1016/j.actatropica.2010.02.006 [doi]
PST - ppublish
SO  - Acta Trop. 2010 Jul-Aug;115(1-2):163-4. doi: 10.1016/j.actatropica.2010.02.006.
      Epub 2010 Feb 11.


PMID- 20152931
OWN - NLM
STAT- MEDLINE
DCOM- 20101028
LR  - 20100712
IS  - 1532-0480 (Electronic)
IS  - 1532-0464 (Linking)
VI  - 43
IP  - 4
DP  - 2010 Aug
TI  - Comparing risks of alternative medical diagnosis using Bayesian arguments.
PG  - 485-95
LID - 10.1016/j.jbi.2010.02.004 [doi]
AB  - This paper explains the role of Bayes Theorem and Bayesian networks arising in a 
      medical negligence case brought by a patient who suffered a stroke as a result of
      an invasive diagnostic test. The claim of negligence was based on the premise
      that an alternative (non-invasive) test should have been used because it carried 
      a lower risk. The case raises a number of general and widely applicable concerns 
      about the decision-making process within the medical profession, including the
      ethics of informed consent, patient care liabilities when errors are made, and
      the research problem of focusing on 'true positives' while ignoring 'false
      positives'. An immediate concern is how best to present Bayesian arguments in
      such a way that they can be understood by people who would normally balk at
      mathematical equations. We feel it is possible to present purely visual
      representations of a non-trivial Bayesian argument in such a way that no
      mathematical knowledge or understanding is needed. The approach supports a wide
      range of alternative scenarios, makes all assumptions easily understandable and
      offers significant potential benefits to many areas of medical decision-making.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Fenton, Norman
AU  - Fenton N
AD  - Queen Mary University of London, RADAR (Risk Assessment and Decision Analysis
      Research), School of Electronic Engineering and Computer Science, London E1 4NS, 
      UK. norman@dcs.qmul.ac.uk
FAU - Neil, Martin
AU  - Neil M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20100210
PL  - United States
TA  - J Biomed Inform
JT  - Journal of biomedical informatics
JID - 100970413
SB  - IM
MH  - *Bayes Theorem
MH  - Decision Making
MH  - Diagnostic Errors/prevention & control
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Malpractice
MH  - Risk Assessment
EDAT- 2010/02/16 06:00
MHDA- 2010/10/29 06:00
CRDT- 2010/02/16 06:00
PHST- 2008/12/16 00:00 [received]
PHST- 2010/01/02 00:00 [revised]
PHST- 2010/02/07 00:00 [accepted]
PHST- 2010/02/16 06:00 [entrez]
PHST- 2010/02/16 06:00 [pubmed]
PHST- 2010/10/29 06:00 [medline]
AID - S1532-0464(10)00019-5 [pii]
AID - 10.1016/j.jbi.2010.02.004 [doi]
PST - ppublish
SO  - J Biomed Inform. 2010 Aug;43(4):485-95. doi: 10.1016/j.jbi.2010.02.004. Epub 2010
      Feb 10.


PMID- 20152592
OWN - NLM
STAT- MEDLINE
DCOM- 20100504
LR  - 20181201
IS  - 1873-6513 (Electronic)
IS  - 0885-3924 (Linking)
VI  - 39
IP  - 2
DP  - 2010 Feb
TI  - A systematic review of oxymorphone in the management of chronic pain.
PG  - 296-308
LID - 10.1016/j.jpainsymman.2009.07.010 [doi]
AB  - Opioids are recommended for control of moderate-to-severe, chronic, malignant,
      and nonmalignant pain. A controlled-release formulation of the opioid oxymorphone
      has recently been launched. The aim of this review was to assess the
      effectiveness of oxymorphone as an analgesic in chronic pain. A systematic search
      for published studies of oral oxymorphone in the management of chronic pain was
      conducted. The studies were evaluated for their internal validity according to
      standard criteria. They were also evaluated for their external validity and
      research ethic aspects. A meta-analysis was performed to examine the effect of
      oxymorphone compared with placebo. Nine studies were evaluated; three were
      excluded because of low quality. Six controlled studies (duration 2-12 weeks)
      included a total of 1489 subjects suffering from chronic low back pain, chronic
      pain from osteoarthritis, and chronic cancer pain. Three of the studies were of
      high quality and three of medium quality. External validity was assessed to be
      high, medium, and low (in one, three, and two studies, respectively). The
      meta-analysis suggests that daily doses of 40-100mg are superior to placebo;
      however, the estimate (reduction of pain intensity compared with placebo) of the 
      treatment effect is imprecise (95% confidence interval -17.08, -8.69). Limited
      evidence suggests that oxymorphone is effective for pain control in patients with
      cancer. No significant differences between oxymorphone and oxycodone at
      equipotent doses were found. In conclusion, oxymorphone is superior to placebo.
      There is no evidence that the efficacy of oxymorphone differs from other opioids.
CI  - Copyright 2010 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. All 
      rights reserved.
FAU - Mayyas, Fadia
AU  - Mayyas F
AD  - Pain and Palliation Research Group, Norwegian University of Science and
      Technology, 7489Trondheim, Norway.
FAU - Fayers, Peter
AU  - Fayers P
FAU - Kaasa, Stein
AU  - Kaasa S
FAU - Dale, Ola
AU  - Dale O
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
PL  - United States
TA  - J Pain Symptom Manage
JT  - Journal of pain and symptom management
JID - 8605836
RN  - 0 (Analgesics, Opioid)
RN  - 9VXA968E0C (Oxymorphone)
SB  - IM
MH  - Analgesics, Opioid/adverse effects/*therapeutic use
MH  - Chronic Disease
MH  - Humans
MH  - Low Back Pain/drug therapy
MH  - Neoplasms/complications
MH  - Osteoarthritis/complications
MH  - Oxymorphone/adverse effects/*therapeutic use
MH  - Pain/*drug therapy/etiology
MH  - Randomized Controlled Trials as Topic
RF  - 47
EDAT- 2010/02/16 06:00
MHDA- 2010/05/05 06:00
CRDT- 2010/02/16 06:00
PHST- 2008/10/16 00:00 [received]
PHST- 2009/07/06 00:00 [revised]
PHST- 2009/07/15 00:00 [accepted]
PHST- 2010/02/16 06:00 [entrez]
PHST- 2010/02/16 06:00 [pubmed]
PHST- 2010/05/05 06:00 [medline]
AID - S0885-3924(09)01140-3 [pii]
AID - 10.1016/j.jpainsymman.2009.07.010 [doi]
PST - ppublish
SO  - J Pain Symptom Manage. 2010 Feb;39(2):296-308. doi:
      10.1016/j.jpainsymman.2009.07.010.


PMID- 20152591
OWN - NLM
STAT- MEDLINE
DCOM- 20100504
LR  - 20211020
IS  - 1873-6513 (Electronic)
IS  - 0885-3924 (Linking)
VI  - 39
IP  - 2
DP  - 2010 Feb
TI  - Palliating a pandemic: "all patients must be cared for".
PG  - 291-5
LID - 10.1016/j.jpainsymman.2009.11.241 [doi]
AB  - In the event of an overwhelming influenza pandemic, many health care systems will
      implement a triage system that would potentially deny critical care treatment to 
      some seriously ill patients. Although all triage systems have guaranteed
      palliative care for those who are denied critical care, no jurisdiction has yet
      developed a plan to accommodate the anticipated "surge" in demand for palliative 
      care. The authors present a mathematical and ethical justification for a
      palliative care surge plan and outline some of the key elements that should be
      included in such a plan.
CI  - Copyright 2010 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. All 
      rights reserved.
FAU - Downar, James
AU  - Downar J
AD  - Department of Medicine, University of Toronto, Toronto, Ontario M5G 2C4, Canada. 
      james.downar@utoronto.ca
FAU - Seccareccia, Dori
AU  - Seccareccia D
CN  - Associated Medical Services Inc. Educational Fellows in Care at the End of Life
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Pain Symptom Manage
JT  - Journal of pain and symptom management
JID - 8605836
SB  - IM
MH  - Disaster Planning
MH  - *Disease Outbreaks
MH  - Humans
MH  - Influenza, Human/*epidemiology/*therapy
MH  - Ontario
MH  - Palliative Care/*ethics/*standards
PMC - PMC7135517
IR  - Farquar D
FIR - Farquar, Donald
IR  - Schulz V
FIR - Schulz, Valerie
IR  - Frank C
FIR - Frank, Chris
IR  - Dugan A
FIR - Dugan, Alison
IR  - Bimji K
FIR - Bimji, Khadija
IR  - Dorasamy P
FIR - Dorasamy, Punginathn
IR  - Berman H
FIR - Berman, Hershl
IR  - Easson A
FIR - Easson, Alexandra
IR  - Downar J
FIR - Downar, James
IR  - Mikhael J
FIR - Mikhael, Joseph
EDAT- 2010/02/16 06:00
MHDA- 2010/05/05 06:00
CRDT- 2010/02/16 06:00
PHST- 2009/11/09 00:00 [received]
PHST- 2009/11/16 00:00 [revised]
PHST- 2009/11/18 00:00 [accepted]
PHST- 2010/02/16 06:00 [entrez]
PHST- 2010/02/16 06:00 [pubmed]
PHST- 2010/05/05 06:00 [medline]
AID - S0885-3924(09)01143-9 [pii]
AID - 10.1016/j.jpainsymman.2009.11.241 [doi]
PST - ppublish
SO  - J Pain Symptom Manage. 2010 Feb;39(2):291-5. doi:
      10.1016/j.jpainsymman.2009.11.241.


PMID- 20152351
OWN - NLM
STAT- MEDLINE
DCOM- 20100422
LR  - 20141120
IS  - 1531-5037 (Electronic)
IS  - 0022-3468 (Linking)
VI  - 45
IP  - 2
DP  - 2010 Feb
TI  - Thoracoscopic repair of congenital diaphragmatic hernia: intraoperative
      ventilation and recurrence.
PG  - 355-9
LID - 10.1016/j.jpedsurg.2009.10.072 [doi]
AB  - INTRODUCTION: Thoracoscopic repair of congenital diaphragmatic hernia (CDH) has
      been described, but its efficacy and safety have not been validated. The aim was 
      to compare our experience of thoracoscopy with laparotomy repair. METHODS: After 
      ethics approval, we reviewed the notes of neonates with CDH operated in our
      institution between 2003 and 2008. Two historical groups were compared: infants
      who underwent laparotomy (2003-2008) or thoracoscopy (2007-2008). Data were
      compared by t test or Mann-Whitney tests. RESULTS: Thirty-five children had open 
      repair of CDH, and 13 had thoracoscopic repair. Groups were homogeneous for age
      and weight. Five (38%) neonates who had thoracoscopy were converted to open for
      surgical difficulties (n = 4) and O(2) desaturation (n = 1). Patch repair was
      used in 12 (34%) open and 6 (46%) thoracoscopic repairs. End-tidal CO(2) was
      significantly elevated during thoracoscopy, but this was not reflected in
      arterial CO(2) or pH. There were 3 (8%) recurrences after open repair and 2 (25%)
      after thoracoscopy (P = .19). CONCLUSION: Thoracoscopic repair of CDH is
      feasible. Arterial blood gases should be closely monitored. Despite higher
      EtCO(2), conversion to open was mainly because of difficult repair. A randomized 
      trial is necessary to assess the effect of thoracoscopy on ventilation and
      recurrences.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - McHoney, Merrill
AU  - McHoney M
AD  - Department of Paediatric Surgery, Great Ormond Street Hospital and the UCL
      Institute of Child Health, London WC1N 1EH, UK.
FAU - Giacomello, Luca
AU  - Giacomello L
FAU - Nah, Shireen A
AU  - Nah SA
FAU - De Coppi, Paolo
AU  - De Coppi P
FAU - Kiely, Edward M
AU  - Kiely EM
FAU - Curry, Joe I
AU  - Curry JI
FAU - Drake, David P
AU  - Drake DP
FAU - Eaton, Simon
AU  - Eaton S
FAU - Pierro, Agostino
AU  - Pierro A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Pediatr Surg
JT  - Journal of pediatric surgery
JID - 0052631
RN  - 142M471B3J (Carbon Dioxide)
SB  - IM
MH  - Acid-Base Imbalance/prevention & control
MH  - Blood Chemical Analysis
MH  - Carbon Dioxide/administration & dosage/blood
MH  - Extracorporeal Membrane Oxygenation/methods
MH  - Female
MH  - Hernia, Diaphragmatic/blood/*surgery
MH  - Hernias, Diaphragmatic, Congenital
MH  - Humans
MH  - Hypercapnia/prevention & control
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Infant, Small for Gestational Age
MH  - Insufflation
MH  - Intraoperative Care
MH  - Laparotomy/methods
MH  - Pregnancy
MH  - Preoperative Care/methods
MH  - Recurrence
MH  - Respiration, Artificial/*methods
MH  - Thoracoscopy/*methods
MH  - Treatment Outcome
EDAT- 2010/02/16 06:00
MHDA- 2010/04/23 06:00
CRDT- 2010/02/16 06:00
PHST- 2009/10/21 00:00 [received]
PHST- 2009/10/27 00:00 [accepted]
PHST- 2010/02/16 06:00 [entrez]
PHST- 2010/02/16 06:00 [pubmed]
PHST- 2010/04/23 06:00 [medline]
AID - S0022-3468(09)00871-9 [pii]
AID - 10.1016/j.jpedsurg.2009.10.072 [doi]
PST - ppublish
SO  - J Pediatr Surg. 2010 Feb;45(2):355-9. doi: 10.1016/j.jpedsurg.2009.10.072.


PMID- 20152345
OWN - NLM
STAT- MEDLINE
DCOM- 20100422
LR  - 20100215
IS  - 1531-5037 (Electronic)
IS  - 0022-3468 (Linking)
VI  - 45
IP  - 2
DP  - 2010 Feb
TI  - Peritoneal drainage does not stabilize extremely low birth weight infants with
      perforated bowel: data from the NET Trial.
PG  - 324-8; discussion 328-9
LID - 10.1016/j.jpedsurg.2009.10.066 [doi]
AB  - INTRODUCTION: Proponents of peritoneal drainage (PD) hypothesize that it allows
      stabilization before laparotomy. We examined this hypothesis by comparing
      clinical status before and after either PD or primary laparotomy (LAP). METHODS: 
      In an ethically approved, international, prospective randomized controlled trial 
      (2002-2006), extremely low birth weight (<1000 g) infants with pneumoperitoneum
      received primary PD (n = 35) or LAP (n = 34). Physiologic data were collected
      prospectively and organ failure scores calculated and compared between
      preprocedure and day 1 after procedure. Data, expressed as mean +/- SD or median 
      (range), were analyzed using appropriate statistical tests. RESULTS: There was no
      postprocedure improvement in either PD or LAP group comparing heart rate (PD, P =
      1.0; LAP, P = .6), blood pressure (PD, P = .6; LAP, P = .8), inotrope requirement
      (PD, P = .2; LAP, P = .3), or Arterial partial pressure of oxygen/fraction of
      inspired oxygen ratio (PD, P = .1; LAP, P = .5). Infants managed with PD had a
      worsening cardiovascular status (P = .05). There were no differences in total
      organ failure score in either group (PD, P = .5; LAP, P = 1). Only 4 infants
      survived with PD alone with no difference between preprocedure and postprocedure 
      organ failure score (P = .4). CONCLUSIONS: Peritoneal drainage does not
      immediately improve clinical status in extremely low birth weight infants with
      bowel perforation. The use of PD as a stabilizing or temporizing measure is not
      supported by these results.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Rees, Clare M
AU  - Rees CM
AD  - Department of Pediatric Surgery, UCL Institute of Child Health and Great Ormond
      Street Hospital for Children NHS Trust, London WC1N 1EH, United Kingdom.
FAU - Eaton, Simon
AU  - Eaton S
FAU - Khoo, A Kate
AU  - Khoo AK
FAU - Kiely, Edward M
AU  - Kiely EM
CN  - Members of NET Trial Group
FAU - Pierro, Agostino
AU  - Pierro A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Pediatr Surg
JT  - Journal of pediatric surgery
JID - 0052631
SB  - IM
MH  - Drainage/*methods
MH  - Enterocolitis, Necrotizing/*surgery
MH  - Humans
MH  - Infant, Extremely Low Birth Weight/physiology
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Intestinal Perforation/*surgery
MH  - Laparotomy/*methods
MH  - Multiple Organ Failure/diagnosis/epidemiology
MH  - Peritoneum/surgery
MH  - Pneumoperitoneum/surgery
MH  - Postoperative Care
MH  - Postoperative Complications/diagnosis/epidemiology
MH  - Preoperative Care
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Survival Analysis
MH  - Treatment Outcome
IR  - Nika A
FIR - Nika, A
IR  - Gamba P
FIR - Gamba, P
IR  - Zamparelli M
FIR - Zamparelli, M
IR  - Jawaheer G
FIR - Jawaheer, G
IR  - Clarke S
FIR - Clarke, S
IR  - Miserez M
FIR - Miserez, M
IR  - Davenport M
FIR - Davenport, M
IR  - Bagolan P
FIR - Bagolan, P
IR  - Morini F
FIR - Morini, F
IR  - Carnielli VP
FIR - Carnielli, V P
IR  - Calisti A
FIR - Calisti, A
IR  - Yeung CA
FIR - Yeung, C A
IR  - Tam PK
FIR - Tam, P K H
IR  - Marven S
FIR - Marven, S
IR  - Morreau P
FIR - Morreau, P
IR  - Hamill J
FIR - Hamill, J
IR  - Gitzelmann C
FIR - Gitzelmann, C
IR  - Surana R
FIR - Surana, R
IR  - Hollwarth M
FIR - Hollwarth, M
IR  - Beyerlein F
FIR - Beyerlein, F
EDAT- 2010/02/16 06:00
MHDA- 2010/04/23 06:00
CRDT- 2010/02/16 06:00
PHST- 2009/10/14 00:00 [received]
PHST- 2009/10/27 00:00 [accepted]
PHST- 2010/02/16 06:00 [entrez]
PHST- 2010/02/16 06:00 [pubmed]
PHST- 2010/04/23 06:00 [medline]
AID - S0022-3468(09)00865-3 [pii]
AID - 10.1016/j.jpedsurg.2009.10.066 [doi]
PST - ppublish
SO  - J Pediatr Surg. 2010 Feb;45(2):324-8; discussion 328-9. doi:
      10.1016/j.jpedsurg.2009.10.066.


PMID- 20152189
OWN - NLM
STAT- MEDLINE
DCOM- 20100409
LR  - 20100215
IS  - 0001-2092 (Print)
IS  - 0001-2092 (Linking)
VI  - 91
IP  - 2
DP  - 2010 Feb
TI  - Nursing's code of ethics.
PG  - 200-1
LID - 10.1016/j.aorn.2009.12.014 [doi]
FAU - Schmitt, Catherine A
AU  - Schmitt CA
LA  - eng
PT  - Comment
PT  - Letter
PL  - United States
TA  - AORN J
JT  - AORN journal
JID - 0372403
SB  - IM
CON - AORN J. 2009 Oct;90(4):489-92. PMID: 19801001
MH  - American Nurses' Association
MH  - *Codes of Ethics
MH  - Humans
MH  - *Operating Room Nursing/education/ethics
MH  - Practice Guidelines as Topic
MH  - United States
EDAT- 2010/02/16 06:00
MHDA- 2010/04/10 06:00
CRDT- 2010/02/16 06:00
PHST- 2010/02/16 06:00 [entrez]
PHST- 2010/02/16 06:00 [pubmed]
PHST- 2010/04/10 06:00 [medline]
AID - S0001-2092(09)00983-1 [pii]
AID - 10.1016/j.aorn.2009.12.014 [doi]
PST - ppublish
SO  - AORN J. 2010 Feb;91(2):200-1. doi: 10.1016/j.aorn.2009.12.014.


PMID- 20151986
OWN - NLM
STAT- MEDLINE
DCOM- 20101019
LR  - 20100719
IS  - 1523-1739 (Electronic)
IS  - 0888-8892 (Linking)
VI  - 24
IP  - 4
DP  - 2010 Aug
TI  - From adaptive management to adjustive management: a pragmatic account of
      biodiversity values.
PG  - 966-73
LID - 10.1111/j.1523-1739.2009.01437.x [doi]
AB  - The conservation of biodiversity poses an exceptionally difficult problem in that
      it needs to be effective in a context of double uncertainty: scientific (i.e.,
      how to conserve biodiversity) and normative (i.e., which biodiversity to conserve
      and why). Although adaptive management offers a promising approach to overcome
      scientific uncertainty, normative uncertainty is seldom tackled by conservation
      science. We expanded on the approach proposed by adaptive-management theorists by
      devising an integrative and iterative approach to conservation that encompasses
      both types of uncertainty. Inspired by environmental pragmatism, we suggest that 
      moral values at stake in biodiversity conservation are plastic and that a
      plurality of individual normative positions can coexist and evolve. Moral values 
      should thus be explored through an experimental process as additional parameters 
      to be incorporated in the traditional adaptive-management approach. As such,
      moral values should also be monitored by environmental ethicists working side by 
      side with scientists and managers on conservation projects. Acknowledging the
      diversity of moral values and integrating them in a process of collective
      deliberation will help overcome the normative uncertainty. We used Dewey's
      distinction between adaptation and adjustment to offer a new paradigm built
      around what we call adjustive management, which reflects both the uncertainty and
      the likely evolution of the moral values humans attribute to biodiversity. We
      illustrate how this paradigm relates to practical conservation decisions by
      exploring the case of the Sacred Ibis (Threskiornis aethiopicus), an alien
      species in France that is the target of an eradication plan undertaken with
      little regard for moral issues. We propose that a more satisfying result of
      efforts to control Sacred Ibis could have been reached by rerouting the
      traditional feedback loop of adaptive management to include a normative inquiry. 
      This adjustive management approach now needs to be tested in real-case
      conservation programs.
FAU - Maris, Virginie
AU  - Maris V
AD  - Museum National d'Histoire Naturelle, Departement Hommes Natures Societes, 36 rue
      Geoffroy St-Hilaire, 75005 Paris, France. virginie.maris@cefe.cnrs.fr
FAU - Bechet, Arnaud
AU  - Bechet A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100211
PL  - United States
TA  - Conserv Biol
JT  - Conservation biology : the journal of the Society for Conservation Biology
JID - 9882301
SB  - IM
MH  - Animals
MH  - *Biodiversity
MH  - Birds/*physiology
MH  - Conservation of Natural Resources/*methods
MH  - Cultural Evolution
MH  - Ethical Theory
MH  - France
MH  - *Models, Theoretical
MH  - *Social Values
MH  - Uncertainty
EDAT- 2010/02/16 06:00
MHDA- 2010/10/20 06:00
CRDT- 2010/02/16 06:00
PHST- 2010/02/16 06:00 [entrez]
PHST- 2010/02/16 06:00 [pubmed]
PHST- 2010/10/20 06:00 [medline]
AID - CBI1437 [pii]
AID - 10.1111/j.1523-1739.2009.01437.x [doi]
PST - ppublish
SO  - Conserv Biol. 2010 Aug;24(4):966-73. doi: 10.1111/j.1523-1739.2009.01437.x. Epub 
      2010 Feb 11.


PMID- 20441641
OWN - NLM
STAT- MEDLINE
DCOM- 20160423
LR  - 20181201
IS  - 0995-3914 (Print)
IS  - 0995-3914 (Linking)
VI  - 21 Spec No 2
DP  - 2010 Feb 16
TI  - [Not Available].
PG  - 89-103
AB  - In 2005, a 12-week health promotion campaign in Quebec utilized a multimedia
      communications strategy in which a website was used to supply information and to 
      serve as an accompaniment to support individual engagement with the campaign. The
      "Defi Sante 5/30" or "5/30 Health Challenge" was intended to reinforce behaviours
      related to healthy eating and the regular practice of physical activity. This
      communications strategy offered the public the ability to personally engage in a 
      "health challenge" by fixing objectives to attain over the course of the
      campaign. The campaign's media use and impact are evaluated with the aid of a
      telephone survey (n = 609), discussion groups with individuals (n = 102) who had 
      been exposed to the campaign, and discussion groups with health professionals (n 
      = 32). The article explores underlying explanations for behavioural changes
      during the campaign with a focus on the role of the website. Several
      characteristics can potentially contribute to the development of motivation and
      fidelity in users: specific objectives of the website; content; architecture and 
      usage techniques; media convergence and contribution of partners; an
      accompaniment approach that is at once virtual, media-based, interpersonal while 
      also using contributions from health professionals. Non-facilitating factors are 
      also discussed: technical and socio-cultural accessibility; ethics and
      constraints related to the participation of health professionals. The "Defi Sante
      5/30" has demonstrated that a website utilizing virtual, media-based,
      interpersonal and technical accompaniment can contribute to behavioural change.
FAU - Renaud, Lise
AU  - Renaud L
FAU - Caron Bouchard, Monique
AU  - Caron Bouchard M
LA  - fre
PT  - Journal Article
TT  - Impact d'un site internet dans une campagne de promotion de la sante : le << Defi
      Sante 5/30 >>
PL  - France
TA  - Sante Publique
JT  - Sante publique (Vandoeuvre-les-Nancy, France)
JID - 9216153
SB  - IM
MH  - *Communication
MH  - *Health Promotion
MH  - Humans
MH  - Quebec
EDAT- 2010/02/16 00:00
MHDA- 2016/04/24 06:00
CRDT- 2010/05/06 06:00
PHST- 2010/05/06 06:00 [entrez]
PHST- 2010/02/16 00:00 [pubmed]
PHST- 2016/04/24 06:00 [medline]
PST - ppublish
SO  - Sante Publique. 2010 Feb 16;21 Spec No 2:89-103.


PMID- 20151431
OWN - NLM
STAT- MEDLINE
DCOM- 20100412
LR  - 20200930
IS  - 1552-4833 (Electronic)
IS  - 1552-4825 (Linking)
VI  - 152A
IP  - 3
DP  - 2010 Mar
TI  - Genetic drift. Overview of German, Nazi, and Holocaust medicine.
PG  - 687-707
LID - 10.1002/ajmg.a.32807 [doi]
AB  - An overview of German, Nazi, and Holocaust medicine brings together a group of
      subjects discussed separately elsewhere. Topics considered include German
      medicine before and during the Nazi era, such as advanced concepts in
      epidemiology, preventive medicine, public health policy, screening programs,
      occupational health laws, compensation for certain medical conditions, and two
      remarkable guidelines for informed consent for medical procedures; also
      considered are the Nuremberg Code; American models for early Nazi programs,
      including compulsory sterilization, abusive medical experiments on prison
      inmates, and discrimination against black people; two ironies in US and Nazi
      laws; social Darwinism and racial hygiene; complicity of Nazi physicians,
      including the acts of sterilization, human experimentation, and genocide; Nazi
      persecution of Jewish physicians; eponyms of unethical German physicians with
      particular emphasis on Reiter, Hallervorden, and Pernkopf; eponyms of famous
      physicians who were Nazi victims, including Pick and van Creveld; and finally, a 
      recommendation for convening an international committee of physicians and
      ethicists to deal with five issues: (a) to propose alternative names for eponyms 
      of physicians who exhibited complicity during the Nazi era; (b) to honor the
      eponyms and stories of physicians who were victims of Nazi atrocities and
      genocide; (c) to apply vigorous pressure to those German and Austrian Institutes 
      that have not yet undertaken investigations to determine if the bodies of Nazi
      victims remain in their collections; (d) to recommend holding annual
      commemorations in medical schools and research institutes worldwide to remember
      and to reflect on the victims of compromised medical practice, particularly, but 
      not exclusively, during the Nazi era because atrocities and acts of genocide have
      occurred elsewhere; and (e) to examine the influence of any political ideology
      that compromises the practice of medicine.
CI  - (c) 2010 Wiley-Liss, Inc
FAU - Cohen, M Michael Jr
AU  - Cohen MM Jr
AD  - Department of Pediatrics, Faculty of Medicine, Dalhousie University, Halifax,
      Nova Scotia, Canada. mmichael.cohenjr@gmail.com
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Portrait
PT  - Review
PL  - United States
TA  - Am J Med Genet A
JT  - American journal of medical genetics. Part A
JID - 101235741
SB  - IM
EIN - Am J Med Genet A. 2012 Jan;158A(1):266
MH  - *Clinical Medicine/history
MH  - Eponyms
MH  - Germany
MH  - History, 20th Century
MH  - *Holocaust/ethics/history
MH  - Homicide/history
MH  - Human Experimentation/ethics/history
MH  - Humans
MH  - Informed Consent/ethics/history
MH  - Jews/history
MH  - *National Socialism/history
MH  - Prejudice
MH  - Prisoners/history
MH  - Sterilization, Involuntary/ethics/history
MH  - United States
RF  - 110
EDAT- 2010/02/13 06:00
MHDA- 2010/04/13 06:00
CRDT- 2010/02/13 06:00
PHST- 2010/02/13 06:00 [entrez]
PHST- 2010/02/13 06:00 [pubmed]
PHST- 2010/04/13 06:00 [medline]
AID - 10.1002/ajmg.a.32807 [doi]
PST - ppublish
SO  - Am J Med Genet A. 2010 Mar;152A(3):687-707. doi: 10.1002/ajmg.a.32807.


PMID- 20151100
OWN - NLM
STAT- MEDLINE
DCOM- 20100517
LR  - 20211020
IS  - 1432-055X (Electronic)
IS  - 0003-2417 (Linking)
VI  - 59
IP  - 2
DP  - 2010 Feb
TI  - [Medical and medical ethical basis of precautionary options].
PG  - 118-25
LID - 10.1007/s00101-010-1687-9 [doi]
AB  - The main activities of anesthesiologists in addition to the operation theatre are
      intensive and emergency treatment as well as pain and palliative care.
      Discussions and decisions about strategies and enforcement of therapy are
      indispensable in all areas. Acknowledgment of the patients' wishes and protection
      of patient autonomy are very important in the context of medical fiduciary duty. 
      Determination of the aim of therapy and the patient's prognosis are of special
      importance. Against the background of the current amendments of patient advance
      directives different possibilities, such as advance directive and emergency forms
      in different areas of anesthesiology will be discussed.
FAU - May, A T
AU  - May AT
AD  - Klinik fur Anasthesiologie, Universitatsklinikum Aachen, Deutschland.
FAU - Brokmann, J C
AU  - Brokmann JC
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Medizinische und medizinethische Grundlagen der Vorsorgemoglichkeiten.
PL  - Germany
TA  - Anaesthesist
JT  - Der Anaesthesist
JID - 0370525
SB  - IM
MH  - Advance Directives
MH  - Anesthesiology/*ethics
MH  - Critical Care/ethics
MH  - Emergency Medical Services/*ethics
MH  - Humans
MH  - Informed Consent
MH  - Palliative Care/*ethics
MH  - Patient Care/ethics
MH  - Patient Rights
MH  - Personal Autonomy
MH  - Prognosis
RF  - 14
EDAT- 2010/02/13 06:00
MHDA- 2010/05/18 06:00
CRDT- 2010/02/13 06:00
PHST- 2010/02/13 06:00 [entrez]
PHST- 2010/02/13 06:00 [pubmed]
PHST- 2010/05/18 06:00 [medline]
AID - 10.1007/s00101-010-1687-9 [doi]
PST - ppublish
SO  - Anaesthesist. 2010 Feb;59(2):118-25. doi: 10.1007/s00101-010-1687-9.


PMID- 20150980
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20100212
LR  - 20211020
IS  - 1743-8454 (Electronic)
IS  - 1743-8454 (Linking)
VI  - 7
DP  - 2010 Jan 11
TI  - Expression and functional activity of nucleoside transporters in human choroid
      plexus.
PG  - 2
LID - 10.1186/1743-8454-7-2 [doi]
AB  - BACKGROUND: Human equilibrative nucleoside transporters (hENTs) 1-3 and human
      concentrative nucleoside transporters (hCNTs) 1-3 in the human choroid plexus
      (hCP) play a role in the homeostasis of adenosine and other naturally occurring
      nucleosides in the brain; in addition, hENT1, hENT2 and hCNT3 mediate membrane
      transport of nucleoside reverse transcriptase inhibitors that could be used to
      treat HIV infection, 3'-azido-3'-deoxythymidine, 2'3'-dideoxycytidine and
      2'3'-dideoxyinosine. This study aimed to explore the expression levels and
      functional activities of hENTs 1-3 and hCNTs 1-3 in human choroid plexus.
      METHODS: Freshly-isolated pieces of lateral ventricle hCP, removed for various
      clinical reasons during neurosurgery, were obtained under Local Ethics Committee 
      approval. Quantification of mRNAs that encoded hENTs and hCNTs was performed by
      the hydrolysis probes-based reverse transcription real time-polymerase chain
      reaction (RT-qPCR); for each gene of interest and for 18 S ribosomal RNA, which
      was an endogenous control, the efficiency of PCR reaction (E) and the
      quantification cycle (Cq) were calculated. The uptake of [(3)H]inosine by the
      choroid plexus pieces was investigated to explore the functional activity of
      hENTs and hCNTs in the hCP. RESULTS: RT-qPCR revealed that the mRNA encoding the 
      intracellularly located transporter hENT3 was the most abundant, with E(-Cq
      )value being only about 40 fold less that the E(-Cq )value for 18 S ribosomal
      RNA; mRNAs encoding hENT1, hENT2 and hCNT3 were much less abundant than mRNA for 
      the hENT3, while mRNAs encoding hCNT1 and hCNT2 were of very low abundance and
      not detectable. Uptake of [(3)H]inosine by the CP samples was linear and
      consisted of an Na(+)-dependent component, which was probably mediated by hCNT3, 
      and Na(+)-independent component, mediated by hENTs. The latter component was not 
      sensitive to inhibition by S-(4-nitrobenzyl)-6-thioinosine (NBMPR), when used at 
      a concentration of 0.5 muM, a finding that excluded the involvement of hENT1, but
      it was very substantially inhibited by 10 muM NBMPR, a finding that suggested the
      involvement of hENT2 in uptake. CONCLUSION: Transcripts for hENT1-3 and hCNT3
      were detected in human CP; mRNA for hENT3, an intracellularly located nucleoside 
      transporter, was the most abundant. Human CP took up radiolabelled inosine by
      both concentrative and equilibrative processes. Concentrative uptake was probably
      mediated by hCNT3; the equilibrative uptake was mediated only by hENT2. The hENT1
      transport activity was absent, which could suggest either that this protein was
      absent in the CP cells or that it was confined to the basolateral side of the CP 
      epithelium.
FAU - Redzic, Zoran B
AU  - Redzic ZB
AD  - Department of Physiology, Faculty of Medicine, Kuwait University, P O Box 24923, 
      Kuwait.
FAU - Malatiali, Slava A
AU  - Malatiali SA
FAU - Grujicic, Danica
AU  - Grujicic D
FAU - Isakovic, Aleksandra J
AU  - Isakovic AJ
LA  - eng
PT  - Journal Article
DEP - 20100111
PL  - England
TA  - Cerebrospinal Fluid Res
JT  - Cerebrospinal fluid research
JID - 101237904
PMC - PMC2820436
EDAT- 2010/02/13 06:00
MHDA- 2010/02/13 06:01
CRDT- 2010/02/13 06:00
PHST- 2009/10/09 00:00 [received]
PHST- 2010/01/11 00:00 [accepted]
PHST- 2010/02/13 06:00 [entrez]
PHST- 2010/02/13 06:00 [pubmed]
PHST- 2010/02/13 06:01 [medline]
AID - 10.1186/1743-8454-7-2 [doi]
PST - epublish
SO  - Cerebrospinal Fluid Res. 2010 Jan 11;7:2. doi: 10.1186/1743-8454-7-2.


PMID- 20150849
OWN - NLM
STAT- MEDLINE
DCOM- 20100504
LR  - 20220408
IS  - 1827-1596 (Electronic)
IS  - 0375-9393 (Linking)
VI  - 76
IP  - 2
DP  - 2010 Feb
TI  - Open intensive care units: a regional survey about the beliefs and attitudes of
      healthcare professionals.
PG  - 93-9
AB  - AIM: We aimed at assessing the opinion and degree of acceptance of physicians and
      nurses in Intensive Care Units (ICUs) toward an open ICU as our regional ethical 
      committee has advised that ICU visitation policies be reformed using such a new
      approach. METHODS: This was a descriptive, cross-sectional, multicenter survey
      using the Beliefs and Attitudes toward Visitation in ICU Questionnaire mailed to 
      the ICUs in our region. RESULTS: A total of 28 ICUs were invited, and 25 agreed
      to participate in this survey; 377 nurses and 230 physicians were surveyed with
      overall response rates of 94.9%% and 84.7%%, respectively. Nurses considered an
      open visiting policy to be an infringement on patient privacy (P<0.01), a
      possible interference with interactions between caregivers (P<0.01) and an
      impediment to their duties (P<0.05). They also significantly differed from
      physicians in considering open visitations a cause of more adverse hemodynamic
      events (P<0.05) and higher physiological and psychological stress for patients
      (P<0.05). With regard to attitudes, nurses strongly disagreed more frequently
      with the following: allowing everyone to visit the patient, accepting an open
      visitation policy in their unit, giving control of the visitation policy to the
      patient (P<0.01) and adapting visitation to the culture/ethnicity of the patients
      (P<0.0001). CONCLUSIONS: This study points out that, in our region, physicians
      are more liberal and able than nurses to "customize" their wards to the specific 
      psychosocial and emotional needs of patients and visitors.
FAU - Biancofiore, G
AU  - Biancofiore G
AD  - Anestesia e Rianimazione SSN, Azienda Ospedaliero-Universitaria Pisana, Cisanello
      Hospital, Pisa, Italy. g.biancofiore@med.unipi.it
FAU - Bindi, L M
AU  - Bindi LM
FAU - Barsotti, E
AU  - Barsotti E
FAU - Menichini, S
AU  - Menichini S
FAU - Baldini, S
AU  - Baldini S
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Minerva Anestesiol
JT  - Minerva anestesiologica
JID - 0375272
SB  - IM
CIN - Minerva Anestesiol. 2010 Nov;76(11):970. PMID: 20634792
MH  - Adult
MH  - Cross-Sectional Studies
MH  - Data Collection
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Intensive Care Units/*organization & administration
MH  - Italy
MH  - Male
MH  - Middle Aged
MH  - Nurses
MH  - Organizational Policy
MH  - Physicians
MH  - Surveys and Questionnaires
MH  - *Visitors to Patients
EDAT- 2010/02/13 06:00
MHDA- 2010/05/05 06:00
CRDT- 2010/02/13 06:00
PHST- 2010/02/13 06:00 [entrez]
PHST- 2010/02/13 06:00 [pubmed]
PHST- 2010/05/05 06:00 [medline]
AID - R02105600 [pii]
PST - ppublish
SO  - Minerva Anestesiol. 2010 Feb;76(2):93-9.


PMID- 20149778
OWN - NLM
STAT- MEDLINE
DCOM- 20100614
LR  - 20151119
IS  - 1877-0665 (Electronic)
IS  - 1877-0657 (Linking)
VI  - 53
IP  - 2
DP  - 2010 Mar
TI  - Patients in a permanent vegetative state or minimally conscious state in the
      Maine-et-Loire county of France: A cross-sectional, descriptive study.
PG  - 96-104
LID - 10.1016/j.rehab.2010.01.002 [doi]
AB  - PURPOSES: To determine how many patients in a permanent vegetative state or a
      minimally conscious state are living in healthcare institutions in the
      Maine-et-Loire county of western France. To evaluate patient management, physical
      complications, problems encountered by nursing staff and the patient care teams' 
      wishes. PATIENTS AND METHODS: We performed a cross-sectional, descriptive study
      in physical medicine and rehabilitation departments, nursing homes, geriatric
      units and local hospitals. All patients and their medical records were examined
      by the same investigator. A questionnaire for carers was used to evaluate nursing
      tasks and a second questionnaire for head nurses served to assess staff needs and
      the patient care teams' wishes. RESULTS: Thirteen patients were identified. Four 
      were in a permanent vegetative state and nine were in a minimally conscious
      state. Ten patients were cared for in geriatric units, one in a physical medicine
      and rehabilitation department and two in local hospitals. All patients displayed 
      limited joint angle ranges. All the patient care teams reported practical
      difficulties and ethical issues. DISCUSSION: Our survey highlighted the variety
      of care scenarios for patients in a permanent vegetative state or a minimally
      conscious state. It revealed practical difficulties and, above all, ethical
      questions. The present work could serve as a basis for implementation of a
      recently issued French government circular on defining specific wards for these
      patients.
CI  - 2010 Elsevier Masson SAS. All rights reserved.
FAU - Saout, V
AU  - Saout V
AD  - CRRRF-CHU d'Angers, France. vsaout8@gmail.com
FAU - Ombredane, M-P
AU  - Ombredane MP
FAU - Mouillie, J-M
AU  - Mouillie JM
FAU - Marteau, C
AU  - Marteau C
FAU - Mathe, J-F
AU  - Mathe JF
FAU - Richard, I
AU  - Richard I
LA  - eng
LA  - fre
PT  - Journal Article
DEP - 20100128
PL  - Netherlands
TA  - Ann Phys Rehabil Med
JT  - Annals of physical and rehabilitation medicine
JID - 101502773
SB  - IM
MH  - Adult
MH  - Advance Directives
MH  - Aged
MH  - Caregivers
MH  - Case Management/ethics/organization & administration/statistics & numerical data
MH  - Cross-Sectional Studies
MH  - Enteral Nutrition
MH  - Female
MH  - France/epidemiology
MH  - Health Services Needs and Demand
MH  - Health Services for the Aged/statistics & numerical data
MH  - Hospital Units/statistics & numerical data
MH  - Humans
MH  - Long-Term Care/ethics/methods/statistics & numerical data
MH  - Male
MH  - Middle Aged
MH  - Muscle Spasticity/etiology/rehabilitation
MH  - Nursing, Supervisory
MH  - Patient Care Planning
MH  - Patient Care Team
MH  - Persistent Vegetative State/*epidemiology/nursing/rehabilitation/therapy
MH  - Severity of Illness Index
MH  - Skilled Nursing Facilities/statistics & numerical data
MH  - Surveys and Questionnaires
MH  - Tracheostomy
EDAT- 2010/02/13 06:00
MHDA- 2010/06/15 06:00
CRDT- 2010/02/13 06:00
PHST- 2009/07/02 00:00 [received]
PHST- 2009/11/12 00:00 [accepted]
PHST- 2010/02/13 06:00 [entrez]
PHST- 2010/02/13 06:00 [pubmed]
PHST- 2010/06/15 06:00 [medline]
AID - S1877-0657(10)00003-5 [pii]
AID - 10.1016/j.rehab.2010.01.002 [doi]
PST - ppublish
SO  - Ann Phys Rehabil Med. 2010 Mar;53(2):96-104. doi: 10.1016/j.rehab.2010.01.002.
      Epub 2010 Jan 28.


PMID- 20148923
OWN - NLM
STAT- MEDLINE
DCOM- 20100728
LR  - 20100414
IS  - 1440-169X (Electronic)
IS  - 0012-1592 (Linking)
VI  - 52
IP  - 3
DP  - 2010 Apr
TI  - Generation of genetically modified animals using spermatogonial stem cells.
PG  - 303-10
LID - 10.1111/j.1440-169X.2009.01167.x [doi]
AB  - Spermatogonial stem cells (SSCs) provide the foundation for spermatogenesis, and 
      are unique tissue-specific stem cells because of their ability to transmit
      genetic information to offspring. Generation of knockout mice using mouse SSCs
      became feasible after the successful establishment of protocols for the
      transplantation and long-term culture of these cells, called germline stem (GS)
      cells. Furthermore, SSCs can acquire pluripotentiality similar to that of
      embryonic stem (ES) cells, in addition to their highly differentiated
      spermatogenic potential. These ES-like cells, called multipotent GS (mGS) cells, 
      are capable of generating knockout mice in a manner similar to that of ES cells. 
      The use of GS and mGS cells for animal transgenesis has added a new dimension to 
      gene-targeting technology using ES cells and somatic cell nuclear transfer, which
      has limited application. Furthermore, for regenerative medicine purposes, the use
      of mGS will settle problems such as ethics issues and immunological rejection
      associated with ES cells, as well as risks of insertional mutagenesis associated 
      with integrated genes into induced pluripotent stem cells.
FAU - Takehashi, Masanori
AU  - Takehashi M
AD  - Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi, Osaka, Japan.
      takeham@osaka-ohtani.ac.jp
FAU - Kanatsu-Shinohara, Mito
AU  - Kanatsu-Shinohara M
FAU - Shinohara, Takashi
AU  - Shinohara T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100210
PL  - Japan
TA  - Dev Growth Differ
JT  - Development, growth & differentiation
JID - 0356504
SB  - IM
MH  - Animals
MH  - Animals, Genetically Modified/*genetics
MH  - Cell Culture Techniques
MH  - Gene Targeting/methods
MH  - Humans
MH  - Male
MH  - Mice
MH  - Mice, Knockout/genetics
MH  - Pluripotent Stem Cells/*cytology/transplantation
MH  - Regeneration
MH  - Spermatogonia/*cytology/transplantation
RF  - 64
EDAT- 2010/02/13 06:00
MHDA- 2010/07/29 06:00
CRDT- 2010/02/13 06:00
PHST- 2010/02/13 06:00 [entrez]
PHST- 2010/02/13 06:00 [pubmed]
PHST- 2010/07/29 06:00 [medline]
AID - DGD1167 [pii]
AID - 10.1111/j.1440-169X.2009.01167.x [doi]
PST - ppublish
SO  - Dev Growth Differ. 2010 Apr;52(3):303-10. doi: 10.1111/j.1440-169X.2009.01167.x. 
      Epub 2010 Feb 10.


PMID- 20147933
OWN - NLM
STAT- MEDLINE
DCOM- 20100629
LR  - 20100211
IS  - 1476-5373 (Electronic)
IS  - 0007-0610 (Linking)
VI  - 208
IP  - 3
DP  - 2010 Feb 13
TI  - Evidence-informed dental student recruitment techniques.
PG  - 127-31
LID - 10.1038/sj.bdj.2010.105 [doi]
AB  - The aim of the study described was to measure the performance of potential dental
      students in an evidence-based, objective, structured admission interview, and to 
      compare that performance to student achievement in aptitude tests, tests of
      scientific knowledge, and tests of ability to apply knowledge to dentistry. A
      list of desirable attributes of dental professionals was drawn from the
      literature, omitting those which were considered to be learnt within the dental
      school curriculum. Possession of these attributes were then measured by
      objectively scoring responses to questions framed around a challenging clinical
      scenario. The interview scores were then correlated against student performance
      in an MCQ science for dentistry examination, an applied dental knowledge test,
      and the Graduate Australian Medical student aptitude test. The literature review 
      revealed that sensitivity to others, professionalism, and ethical behaviour were 
      deemed almost as important as academic and technical competency. Correlations of 
      scores from an interview which sought to measure the attributes described in the 
      literature with scores in scientific knowledge tests, aptitude tests and applied 
      dental knowledge tests were low, and did not reach statistical significance. The 
      results suggest that an interview process has been devised which measures the
      importance of characteristics not readily captured in more traditional selection 
      strategies. Because the literature demonstrates that these characteristics are
      important to the public and the profession, this objective interview is a useful 
      selection tool.
FAU - Kay, E
AU  - Kay E
AD  - Peninsula Dental School, Peninsula College ofMedicine and Dentistry, TamarScience
      Park, Plymouth, PL6 8BU. elizabeth.kay@pds.ac.uk
FAU - Bennett, J
AU  - Bennett J
FAU - Allison, P
AU  - Allison P
FAU - Coombes, L R
AU  - Coombes LR
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br Dent J
JT  - British dental journal
JID - 7513219
SB  - IM
MH  - Clinical Competence/*standards
MH  - Education, Dental/*methods
MH  - Educational Measurement/*methods
MH  - Humans
MH  - Personnel Selection
MH  - School Admission Criteria
MH  - Students, Dental/*psychology
MH  - *Temperament
EDAT- 2010/02/12 06:00
MHDA- 2010/06/30 06:00
CRDT- 2010/02/12 06:00
PHST- 2009/11/24 00:00 [accepted]
PHST- 2010/02/12 06:00 [entrez]
PHST- 2010/02/12 06:00 [pubmed]
PHST- 2010/06/30 06:00 [medline]
AID - sj.bdj.2010.105 [pii]
AID - 10.1038/sj.bdj.2010.105 [doi]
PST - ppublish
SO  - Br Dent J. 2010 Feb 13;208(3):127-31. doi: 10.1038/sj.bdj.2010.105.


PMID- 20147677
OWN - NLM
STAT- MEDLINE
DCOM- 20100412
LR  - 20211020
IS  - 1541-0048 (Electronic)
IS  - 0090-0036 (Linking)
VI  - 100 Suppl 1
DP  - 2010 Apr 1
TI  - The moral problem of health disparities.
PG  - S47-51
LID - 10.2105/AJPH.2009.171181 [doi]
AB  - Health disparities exist along lines of race/ethnicity and socioeconomic class in
      US society. I argue that we should work to eliminate these health disparities
      because their existence is a moral wrong that needs to be addressed. Health
      disparities are morally wrong because they exemplify historical injustices.
      Contractarian ethics, Kantian ethics, and utilitarian ethics all provide
      theoretical justification for viewing health disparities as a moral wrong, as do 
      several ethical principles of primary importance in bioethics. The moral
      consequences of health disparities are also troubling and further support the
      claim that these disparities are a moral wrong. The Universal Declaration of
      Human Rights provides additional support that health disparities are a moral
      wrong, as does an analogy with the generally accepted duty to provide equal
      access to education. In this article, I also consider and respond to 3 objections
      to my thesis.
FAU - Jones, Cynthia M
AU  - Jones CM
AD  - Pan American Collaboration for Ethics in Professions, University of Texas-Pan
      American, Edinburg, TX 78539, USA. jonesc@utpa.edu
LA  - eng
PT  - Journal Article
DEP - 20100210
PL  - United States
TA  - Am J Public Health
JT  - American journal of public health
JID - 1254074
SB  - IM
MH  - Health Behavior
MH  - Health Policy
MH  - *Health Status Disparities
MH  - Humans
MH  - *Moral Obligations
MH  - Social Justice
MH  - United States
PMC - PMC2837423
EDAT- 2010/02/12 06:00
MHDA- 2010/04/13 06:00
CRDT- 2010/02/12 06:00
PHST- 2010/02/12 06:00 [entrez]
PHST- 2010/02/12 06:00 [pubmed]
PHST- 2010/04/13 06:00 [medline]
AID - AJPH.2009.171181 [pii]
AID - 10.2105/AJPH.2009.171181 [doi]
PST - ppublish
SO  - Am J Public Health. 2010 Apr 1;100 Suppl 1:S47-51. doi: 10.2105/AJPH.2009.171181.
      Epub 2010 Feb 10.


PMID- 20147426
OWN - NLM
STAT- MEDLINE
DCOM- 20100513
LR  - 20100331
IS  - 1758-1060 (Electronic)
IS  - 1355-8196 (Linking)
VI  - 15 Suppl 2
DP  - 2010 Apr
TI  - HIV testing of health care workers in England--a flawed policy.
PG  - 62-7
LID - 10.1258/jhsrp.2009.009095 [doi]
AB  - A new Department of Health policy in England, published in 2007, recommended
      changes to the pre-employment health checks performed on health care workers
      before taking up their employment. The policy proposed that all new health care
      workers should receive immunization against TB and hepatitis B and should be
      offered testing for hepatitis C and HIV. It also advanced a new requirement that 
      staff who perform exposure-prone procedures must be tested for TB, hepatitis B
      and C and HIV and must test negative for these diseases. Essentially mandatory
      HIV testing has been introduced for a large number of health care workers. The
      aim of the recommendations is to protect patients from contracting serious
      communicable diseases from health care professionals. Secondary objectives of the
      directive are to maintain confidence in the workforce and reduce the burden of
      patient notification exercises. This essay explores some of the shortcomings of
      this policy and examines the reasons why this policy will fail to meet its
      objectives. The justification for this new guidance is questioned and some of the
      ethical issues are highlighted.
FAU - Salkeld, Lee
AU  - Salkeld L
AD  - Valley Medical Centre, Bristol, UK. leesalkeld@hotmail.com
FAU - McGeehan, Sarah
AU  - McGeehan S
LA  - eng
PT  - Journal Article
DEP - 20100210
PL  - England
TA  - J Health Serv Res Policy
JT  - Journal of health services research & policy
JID - 9604936
MH  - Attitude to Health
MH  - Employment/*standards
MH  - England
MH  - HIV Infections/*diagnosis
MH  - *Health Personnel
MH  - *Health Policy
MH  - Hepatitis B/diagnosis
MH  - Hepatitis C/diagnosis
MH  - Humans
MH  - Immunization
MH  - Infectious Disease Transmission, Professional-to-Patient/prevention & control
MH  - *Mandatory Testing/ethics
MH  - State Medicine/ethics/*organization & administration
MH  - Tuberculosis/diagnosis
EDAT- 2010/02/12 06:00
MHDA- 2010/05/14 06:00
CRDT- 2010/02/12 06:00
PHST- 2010/02/12 06:00 [entrez]
PHST- 2010/02/12 06:00 [pubmed]
PHST- 2010/05/14 06:00 [medline]
AID - jhsrp.2009.009095 [pii]
AID - 10.1258/jhsrp.2009.009095 [doi]
PST - ppublish
SO  - J Health Serv Res Policy. 2010 Apr;15 Suppl 2:62-7. doi:
      10.1258/jhsrp.2009.009095. Epub 2010 Feb 10.


PMID- 20146974
OWN - NLM
STAT- MEDLINE
DCOM- 20100323
LR  - 20131121
IS  - 0003-3898 (Print)
IS  - 0003-3898 (Linking)
VI  - 68
IP  - 1
DP  - 2010 Jan-Feb
TI  - [Current issues in measurement and reporting of urinary albumin excretion].
PG  - 9-25
LID - 10.1684/abc.2010.0402 [doi]
AB  - Urinary excretion of albumin indicates kidney damage and is recognized as a risk 
      factor for progression of kidney disease and cardiovascular disease. The role of 
      urinary albumin measurements has focused attention on the clinical need for
      accurate and clearly reported results. The National Kidney Disease Education
      Program and the IFCC convened a conference to assess the current state of
      preanalytical, analytical, and postanalytical issues affecting urine albumin
      measurements and to identify areas needing improvement. The chemistry of albumin 
      in urine is incompletely understood. Current guidelines recommend the use of the 
      albumin/creatinine ratio (ACR) as a surrogate for the erro-prone collection of
      timed urine samples. Although ACR results are affected by patient preparation and
      time of day of sample collection, neither is standardized. Considerable
      intermethod differences has been reported for both albumin and creatinine
      measurement, but trueness is unknown because there are no reference measurement
      procedures for albumin and no referance materials for either analyte in urine.
      The recommanded reference intervals for the ACR do not take into account the
      large intergroup differences in creatinine excretion (e.g., related to
      differences in age, sex, and ethicity) nor the continuous increase in risk
      related to albumin excretion. Clinical needs have been identified for
      standardization of (a) urine collection methodes, (b) urine albumin and
      creatinine measurements based on a complete reference system, (c) reporting of
      test results, and (d) reference intervals for the ACR.
FAU - Miller, W G
AU  - Miller WG
AD  - Department of Pathology, Virginia Commonwealth University, Richmond, VA, USA.
FAU - Bruns, D E
AU  - Bruns DE
FAU - Hortin, G L
AU  - Hortin GL
FAU - Sandberg, S
AU  - Sandberg S
FAU - Aakre, K M
AU  - Aakre KM
FAU - McQueen, M J
AU  - McQueen MJ
FAU - Itoh, Y
AU  - Itoh Y
FAU - Lieske, J C
AU  - Lieske JC
FAU - Seccombe, D W
AU  - Seccombe DW
FAU - Jones, G
AU  - Jones G
FAU - Bunk, D M
AU  - Bunk DM
FAU - Curhan, G C
AU  - Curhan GC
FAU - Narva, A S
AU  - Narva AS
CN  - National Kidney Disease Education Program-IFCC Working Group on Standardization
      of Albumin in Urine
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Donnees actuelles sur le dosage de l'excretion urinaire de l'albumine.
PL  - France
TA  - Ann Biol Clin (Paris)
JT  - Annales de biologie clinique
JID - 2984690R
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Albuminuria/*diagnosis
MH  - Creatinine/urine
MH  - Humans
MH  - Kidney Diseases/diagnosis
MH  - Nephelometry and Turbidimetry
MH  - Reference Standards
MH  - Specimen Handling
EDAT- 2010/02/12 06:00
MHDA- 2010/03/24 06:00
CRDT- 2010/02/12 06:00
PHST- 2010/02/12 06:00 [entrez]
PHST- 2010/02/12 06:00 [pubmed]
PHST- 2010/03/24 06:00 [medline]
AID - abc.2010.0402 [pii]
AID - 10.1684/abc.2010.0402 [doi]
PST - ppublish
SO  - Ann Biol Clin (Paris). 2010 Jan-Feb;68(1):9-25. doi: 10.1684/abc.2010.0402.


PMID- 20146635
OWN - NLM
STAT- MEDLINE
DCOM- 20100726
LR  - 20211020
IS  - 1744-7682 (Electronic)
IS  - 1471-2598 (Linking)
VI  - 10
IP  - 4
DP  - 2010 Apr
TI  - Spermatogonial stem cells, in vivo transdifferentiation and human regenerative
      medicine.
PG  - 519-30
LID - 10.1517/14712591003614731 [doi]
AB  - IMPORTANCE OF THE FIELD: Embryonic stem (ES) cells have potential for use in
      regenerative medicine, but use of these cells is hindered by moral, legal and
      ethical issues. Induced pluripotent cells have promise in regenerative medicine. 
      However, since generation of these cells involves genetic manipulation, it also
      faces significant hurdles before clinical use. This review discusses
      spermatogonial stem cells (SSCs) as a potential alternative source of pluripotent
      cells for use in human regenerative medicine. AREAS COVERED IN THE REVIEW: The
      potential of SSCs to give rise to a wide range of other cell types either
      directly, when recombined with instructive inducers, or indirectly, after being
      converted to ES-like cells. Current understanding of the differentiation
      potential of murine SSCs and recent progress in isolating and culturing human
      SSCs and demonstrating their properties is also discussed. WHAT THE READER WILL
      GAIN: Insight into the plasticity of SSCs and the unique properties of these
      cells for regenerative applications, the limitations of SSCs for stem-cell-based 
      therapy and the potential alternatives available. TAKE HOME MESSAGE: If
      methodologies for isolation and conversion of adult human SSCs directly into
      other cell types can be effectively developed, SSCs could represent an important 
      alternate source of pluripotent cells that can be used in human tissue repair
      and/or regeneration.
FAU - Simon, Liz
AU  - Simon L
AD  - University of Illinois at Urbana Champaign, Veterinary Biosciences, VMBSB, 2001, 
      S. Lincoln Avenue, Urbana, IL 61802, USA.
FAU - Hess, Rex A
AU  - Hess RA
FAU - Cooke, Paul S
AU  - Cooke PS
LA  - eng
GR  - R01 ES011590/ES/NIEHS NIH HHS/United States
GR  - R01 ES011590-04/ES/NIEHS NIH HHS/United States
GR  - T32 ES007326/ES/NIEHS NIH HHS/United States
GR  - CO6RR165 15/CO/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Expert Opin Biol Ther
JT  - Expert opinion on biological therapy
JID - 101125414
SB  - IM
MH  - *Cell Differentiation
MH  - Cell Transdifferentiation
MH  - Humans
MH  - Male
MH  - *Regenerative Medicine
MH  - Spermatogonia/*cytology
MH  - Stem Cells/*cytology
RF  - 110
PMC - PMC6635956
MID - NIHMS326889
EDAT- 2010/02/12 06:00
MHDA- 2010/07/27 06:00
CRDT- 2010/02/12 06:00
PHST- 2010/02/12 06:00 [entrez]
PHST- 2010/02/12 06:00 [pubmed]
PHST- 2010/07/27 06:00 [medline]
AID - 10.1517/14712591003614731 [doi]
PST - ppublish
SO  - Expert Opin Biol Ther. 2010 Apr;10(4):519-30. doi: 10.1517/14712591003614731.


PMID- 20146171
OWN - NLM
STAT- MEDLINE
DCOM- 20100624
LR  - 20181201
IS  - 1439-3646 (Electronic)
IS  - 0947-7349 (Linking)
VI  - 118
IP  - 3
DP  - 2010 Mar
TI  - Human multidrug resistance-1 gene expression levels in graves-basedow disease.
PG  - 158-60
LID - 10.1055/s-0029-1215586 [doi]
AB  - OBJECT: Multidrug resistance 1 gene is responsible for the resistance of a large 
      variety of drugs in human cells. We tried to evaluate this in the present study
      in thyroid stimulant hormone receptor antibody positive subjects. METHOD: In
      study enrolled 23 female and 10 male subjects. Hyperthyroid subjects were treated
      with PTU and remission was assured between 6-12 months. Blood samples were
      collected before the start of this treatment. Permission for this study was taken
      from the patients and the local ethical committee. RESULTS: Serum F-T3, F-T4
      levels in Graves subjects were markedly high, whereas TSH levels were markedly
      low than normal range. We also found that with increased age of the Graves'
      subjects, MDR-1 gene expression decreased. There was also a direct correlation
      between blood MDR-1 gene expression and TSH-R Ab levels in patients with Graves's
      disease. We observed that the duration of being euthyroid was lengthened with the
      elevation of MDR-1 gene expression. There was a direct correlation between blood 
      MDR-1 gene expression levels and ultrasonografic size of thyroid gland.
      CONCLUSION: As a result, raised blood MDR-1 gene expression levels in patients
      with Graves-Basedow disease may be associated with the activity of the disease
      and the resistance to its treatment. The more blood MDR-1 expression increases
      the more the duration of being euthyroid increases.
CI  - J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart * New York.
FAU - Cetinkalp, S
AU  - Cetinkalp S
AD  - Department of Endocrinology and Metabolism, Ege University Medical School, Izmir,
      Turkey.
FAU - Karadeniz, M
AU  - Karadeniz M
FAU - Erdogan, M
AU  - Erdogan M
FAU - Eroglu, Z
AU  - Eroglu Z
FAU - Zengi, A
AU  - Zengi A
FAU - Kosova, B
AU  - Kosova B
FAU - Yilmaz, C
AU  - Yilmaz C
FAU - Tezcanli, B
AU  - Tezcanli B
FAU - Kabalak, T
AU  - Kabalak T
FAU - Ozgen, A G
AU  - Ozgen AG
LA  - eng
PT  - Journal Article
DEP - 20100209
PL  - Germany
TA  - Exp Clin Endocrinol Diabetes
JT  - Experimental and clinical endocrinology & diabetes : official journal, German
      Society of Endocrinology [and] German Diabetes Association
JID - 9505926
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B, Member 1)
RN  - 0 (Immunoglobulins, Thyroid-Stimulating)
RN  - 0 (thyrotropin-binding inhibitory immunoglobulin)
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - 721M9407IY (Propylthiouracil)
RN  - 9002-71-5 (Thyrotropin)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - ATP Binding Cassette Transporter, Subfamily B, Member 1/*blood/*genetics
MH  - Adult
MH  - Age Factors
MH  - Drug Resistance/drug effects/*genetics
MH  - Female
MH  - Gene Expression/drug effects
MH  - Graves Disease/*blood/drug therapy/*genetics
MH  - Humans
MH  - Immunoglobulins, Thyroid-Stimulating/blood
MH  - Male
MH  - Middle Aged
MH  - Propylthiouracil/therapeutic use
MH  - Thyroid Gland/diagnostic imaging
MH  - Thyrotropin/blood
MH  - Thyroxine/blood
MH  - Triiodothyronine/blood
MH  - Ultrasonography
EDAT- 2010/02/11 06:00
MHDA- 2010/06/25 06:00
CRDT- 2010/02/11 06:00
PHST- 2010/02/11 06:00 [entrez]
PHST- 2010/02/11 06:00 [pubmed]
PHST- 2010/06/25 06:00 [medline]
AID - 10.1055/s-0029-1215586 [doi]
PST - ppublish
SO  - Exp Clin Endocrinol Diabetes. 2010 Mar;118(3):158-60. doi:
      10.1055/s-0029-1215586. Epub 2010 Feb 9.


PMID- 20146104
OWN - NLM
STAT- MEDLINE
DCOM- 20100701
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 16
IP  - 1
DP  - 2010 Mar
TI  - Can instruction in engineering ethics change students' feelings about
      professional responsibility?
PG  - 201-15
LID - 10.1007/s11948-010-9195-5 [doi]
AB  - How can a course on engineering ethics affect an undergraduate student's feelings
      of responsibility about moral problems? In this study, three groups of students
      were interviewed: six students who had completed a specific course on engineering
      ethics, six who had registered for the course but had not yet started it, and six
      who had not taken or registered for the course. Students were asked what they
      would do as the central character, an engineer, in each of two short cases that
      posed moral problems. For each case, the role of the engineer was successively
      changed and the student was asked how each change altered his or her decisions
      about the case. Students who had completed the ethics course considered more
      options before making a decision, and they responded consistently despite changes
      in the cases. For both cases, even when they were not directly involved, they
      were more likely to feel responsible and take corrective action. Students who
      were less successful in the ethics course gave answers similar to students who
      had not taken the course. This latter group of students seemed to have weaker
      feelings of responsibility: they would say that a problem was "not my business." 
      It appears that instruction in ethics can increase awareness of responsibility,
      knowledge about how to handle a difficult situation, and confidence in taking
      action.
FAU - Hashemian, Golnaz
AU  - Hashemian G
AD  - Department of Electrical and Computer Engineering and Coordinated Science
      Laboratory, University of Illinois at Urbana-Champaign, Urbana-Champaign, IL,
      USA. golnaz.h@maddockdouglas.com
FAU - Loui, Michael C
AU  - Loui MC
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20100210
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Attitude
MH  - Codes of Ethics
MH  - Confidentiality/ethics
MH  - Conflict of Interest
MH  - Curriculum
MH  - Decision Making/ethics
MH  - Education, Professional/*organization & administration
MH  - Educational Measurement
MH  - *Engineering/education/ethics
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Illinois
MH  - Interprofessional Relations/ethics
MH  - Male
MH  - Professional Role/*psychology
MH  - Program Evaluation
MH  - Self Efficacy
MH  - *Social Responsibility
MH  - Students/*psychology
MH  - Surveys and Questionnaires
MH  - Whistleblowing/ethics
EDAT- 2010/02/11 06:00
MHDA- 2010/07/02 06:00
CRDT- 2010/02/11 06:00
PHST- 2006/09/22 00:00 [received]
PHST- 2009/09/29 00:00 [accepted]
PHST- 2010/02/11 06:00 [entrez]
PHST- 2010/02/11 06:00 [pubmed]
PHST- 2010/07/02 06:00 [medline]
AID - 10.1007/s11948-010-9195-5 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2010 Mar;16(1):201-15. doi: 10.1007/s11948-010-9195-5. Epub 2010 
      Feb 10.


PMID- 20145454
OWN - NLM
STAT- MEDLINE
DCOM- 20100514
LR  - 20181201
IS  - 1538-9766 (Electronic)
IS  - 1042-895X (Linking)
VI  - 33
IP  - 1
DP  - 2010 Jan-Feb
TI  - An ethical dilemma: decision making about liver transplantation in a patient with
      schizophrenia.
PG  - 59-60
LID - 10.1097/SGA.0b013e3181ce3bd2 [doi]
FAU - Sayilir, Abdurrahim
AU  - Sayilir A
FAU - Kekilli, Murat
AU  - Kekilli M
FAU - Kurt, Mevlut
AU  - Kurt M
FAU - Onal, Ibrahim Koral
AU  - Onal IK
FAU - Yesil, Yusuf
AU  - Yesil Y
FAU - Tunc, Bilge
AU  - Tunc B
FAU - Sasmaz, Nurgul
AU  - Sasmaz N
LA  - eng
PT  - Case Reports
PT  - Letter
PL  - United States
TA  - Gastroenterol Nurs
JT  - Gastroenterology nursing : the official journal of the Society of
      Gastroenterology Nurses and Associates
JID - 8915377
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Phosphorus Compounds)
RN  - 7MNE9M8287 (Sulpiride)
RN  - 8110R61I4U (Amisulpride)
MH  - Adult
MH  - Amisulpride
MH  - Antipsychotic Agents/therapeutic use
MH  - Chemical and Drug Induced Liver Injury/etiology
MH  - Contraindications
MH  - Decision Making/*ethics
MH  - Humans
MH  - Liver Failure, Acute/chemically induced/diagnosis
MH  - Liver Transplantation/*ethics
MH  - Male
MH  - Patient Selection/*ethics
MH  - Phosphorus Compounds/poisoning
MH  - Schizophrenia, Paranoid/*complications/drug therapy
MH  - Sulpiride/analogs & derivatives/therapeutic use
EDAT- 2010/02/11 06:00
MHDA- 2010/05/15 06:00
CRDT- 2010/02/11 06:00
PHST- 2010/02/11 06:00 [entrez]
PHST- 2010/02/11 06:00 [pubmed]
PHST- 2010/05/15 06:00 [medline]
AID - 10.1097/SGA.0b013e3181ce3bd2 [doi]
AID - 00001610-201001000-00010 [pii]
PST - ppublish
SO  - Gastroenterol Nurs. 2010 Jan-Feb;33(1):59-60. doi: 10.1097/SGA.0b013e3181ce3bd2.


PMID- 20145187
OWN - NLM
STAT- MEDLINE
DCOM- 20100426
LR  - 20220318
IS  - 1557-3265 (Electronic)
IS  - 1078-0432 (Linking)
VI  - 16
IP  - 4
DP  - 2010 Feb 15
TI  - Phase I oncology studies: evidence that in the era of targeted therapies patients
      on lower doses do not fare worse.
PG  - 1289-97
LID - 10.1158/1078-0432.CCR-09-2684 [doi]
AB  - PURPOSE: To safely assess new drugs, cancer patients in initial cohorts of phase 
      I oncology studies receive low drug doses. Doses are successively increased until
      the maximum tolerated dose (MTD) is determined. Because traditional chemotherapy 
      is often more effective near the MTD, ethical concerns have been raised about
      administration of low drug doses to phase I patients. However, a substantial
      portion of oncology trials now investigate targeted agents, which may have
      different dose-response relationships than cytotoxic chemotherapies. EXPERIMENTAL
      DESIGN: Twenty-four consecutive trials treating 683 patients between October 1,
      2004, and June 30, 2008, at MD Anderson Cancer Center were analyzed. Patients
      were assigned to a low-dose (<or=25% MTD), medium-dose (25-75% MTD), or high-dose
      (>or=75% MTD) group, and groups were compared for response rate,
      time-to-treatment failure, progression-free survival, overall survival, and
      toxicity. To remove negatively biasing data from the high-dose group, in a second
      analysis, patients treated above the MTD were excluded (high-dose group, 75-100% 
      MTD). Of the 683 patients, 97.7% received targeted agents. RESULTS: Even when
      excluding patients above the MTD, there was an early trend favoring the low-
      versus high-dose group in time-to-treatment failure, with 32.9% versus 25.2% of
      patients on therapy at 3 months (P = 0.08). In addition, the low-dose group fared
      at least as well as the other groups in all other outcomes, including response
      rate, progression-free survival, overall survival, and toxicity. CONCLUSIONS:
      These data may help alleviate concerns that patients who receive low drug doses
      on contemporary phase I oncology trials fare worse and suggest targeted agents
      may have different dose-response relationships than cytotoxic chemotherapies.
FAU - Jain, Rajul K
AU  - Jain RK
AD  - Department of Investigational Cancer Therapeutics, Phase I Program, MD Anderson
      Cancer Center, Houston, Texas 77030-4009, USA. rjain@mdanderson.org
FAU - Lee, J Jack
AU  - Lee JJ
FAU - Hong, David
AU  - Hong D
FAU - Markman, Maurie
AU  - Markman M
FAU - Gong, Jing
AU  - Gong J
FAU - Naing, Aung
AU  - Naing A
FAU - Wheler, Jennifer
AU  - Wheler J
FAU - Kurzrock, Razelle
AU  - Kurzrock R
LA  - eng
GR  - P30 CA016672/CA/NCI NIH HHS/United States
GR  - CA16672/CA/NCI NIH HHS/United States
GR  - RR024148/RR/NCRR NIH HHS/United States
GR  - U01 CA062461/CA/NCI NIH HHS/United States
GR  - UL1 RR024148/RR/NCRR NIH HHS/United States
GR  - U01 CA062461-15/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100209
PL  - United States
TA  - Clin Cancer Res
JT  - Clinical cancer research : an official journal of the American Association for
      Cancer Research
JID - 9502500
RN  - 0 (Antineoplastic Agents)
SB  - IM
CIN - Clin Cancer Res. 2010 Feb 15;16(4):1085-7. PMID: 20145182
MH  - Antineoplastic Agents/*administration & dosage/adverse effects
MH  - *Clinical Trials, Phase I as Topic
MH  - Disease-Free Survival
MH  - Dose-Response Relationship, Drug
MH  - *Drug Delivery Systems
MH  - Humans
MH  - Maximum Tolerated Dose
MH  - Neoplasms/*drug therapy/mortality
MH  - Prognosis
MH  - Time Factors
MH  - Treatment Outcome
PMC - PMC2822881
MID - NIHMS160992
EDAT- 2010/02/11 06:00
MHDA- 2010/04/27 06:00
CRDT- 2010/02/11 06:00
PHST- 2010/02/11 06:00 [entrez]
PHST- 2010/02/11 06:00 [pubmed]
PHST- 2010/04/27 06:00 [medline]
AID - 1078-0432.CCR-09-2684 [pii]
AID - 10.1158/1078-0432.CCR-09-2684 [doi]
PST - ppublish
SO  - Clin Cancer Res. 2010 Feb 15;16(4):1289-97. doi: 10.1158/1078-0432.CCR-09-2684.
      Epub 2010 Feb 9.


PMID- 20145005
OWN - NLM
STAT- MEDLINE
DCOM- 20100617
LR  - 20100317
IS  - 1460-2350 (Electronic)
IS  - 0268-1161 (Linking)
VI  - 25
IP  - 4
DP  - 2010 Apr
TI  - Sharing motherhood: biological lesbian co-mothers, a new IVF indication.
PG  - 938-41
LID - 10.1093/humrep/deq008 [doi]
AB  - BACKGROUND: We herein present the initial experiences of the CEFER Institute of
      Reproduction in the formation of a new family model: two biological mothers,
      lesbians, one who provides the eggs and the other who carries the embryo in her
      womb. We have called this family model ROPA (Reception of Oocytes from PArtner). 
      It is a pioneer event in Spain and among the first at a worldwide level. METHODS 
      AND RESULTS: Fourteen lesbian couples have undergone treatment using the ROPA
      technique. This paper briefly describes the technique. Six pregnancies have been 
      obtained from 13 embryo transfers. There were two miscarriages and there are
      three ongoing pregnancies, one of them twins. One healthy female baby was born.
      The following aspects are addressed: (i) legal status of lesbian couples in
      Western countries; (ii) the lesbian couple's access to assisted reproduction
      techniques; (iii) ethical aspects; (iv) medical acceptability; and (v) single
      mother versus lesbian mothers. CONCLUSIONS: In countries where the ROPA technique
      is legal, it offers lesbian couples a more favourable route, involving both
      partners, to start a family, and doctors who treat lesbian couples must be
      sensitive to this new family model.
FAU - Marina, S
AU  - Marina S
AD  - Institute of Reproduction CEFER, Member of ANACER, Marquesa de Vilallonga, 12.
      Desp 21, 08017 Barcelona, Spain. info@institutocefer.com
FAU - Marina, D
AU  - Marina D
FAU - Marina, F
AU  - Marina F
FAU - Fosas, N
AU  - Fosas N
FAU - Galiana, N
AU  - Galiana N
FAU - Jove, I
AU  - Jove I
LA  - eng
PT  - Journal Article
DEP - 20100209
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
SB  - IM
CIN - Hum Reprod. 2010 Apr;25(4):812-4. PMID: 20145004
MH  - Adult
MH  - Female
MH  - Fertilization in Vitro/ethics/*legislation & jurisprudence/*methods
MH  - Health Services Accessibility/ethics/legislation & jurisprudence
MH  - *Homosexuality, Female
MH  - Humans
MH  - Infant, Newborn
MH  - Insemination, Artificial, Heterologous
MH  - Mothers/*legislation & jurisprudence
MH  - Oocyte Donation/ethics/legislation & jurisprudence/methods
MH  - Pregnancy
MH  - Spain
MH  - Surrogate Mothers/*legislation & jurisprudence
EDAT- 2010/02/11 06:00
MHDA- 2010/06/18 06:00
CRDT- 2010/02/11 06:00
PHST- 2010/02/11 06:00 [entrez]
PHST- 2010/02/11 06:00 [pubmed]
PHST- 2010/06/18 06:00 [medline]
AID - deq008 [pii]
AID - 10.1093/humrep/deq008 [doi]
PST - ppublish
SO  - Hum Reprod. 2010 Apr;25(4):938-41. doi: 10.1093/humrep/deq008. Epub 2010 Feb 9.


PMID- 20144939
OWN - NLM
STAT- MEDLINE
DCOM- 20101001
LR  - 20131106
IS  - 1471-8391 (Electronic)
IS  - 0007-1420 (Linking)
VI  - 94
DP  - 2010
TI  - Living-donor liver transplantation in adults.
PG  - 33-48
LID - 10.1093/bmb/ldq003 [doi]
AB  - INTRODUCTION: The technique of paediatric living-donor liver transplantation
      (LDLT) has become standardized. In adults, however, there is scope for
      innovation. Unlike cadaveric whole-size liver transplantation and paediatric
      LDLT, size matching between the liver graft and the recipient by body weight has 
      been a major challenge in adult LDLT because it is important to provide an
      adequate graft mass to the recipient while leaving a sufficient mass of remnant
      liver in the donor to ensure donor safety. GROWING POINTS: In adult LDLT, liver
      grafts have been selected to meet graft-recipient size-matching requirements. In 
      1996, the Hong Kong group pioneered the use of the right-lobe grafts vein to
      overcome the volume insufficiency often encountered with the left-lobe liver
      grafts. Subsequently, the Asan group introduced modified right-lobe grafting with
      interposition vein grafts to drain the venous outflow of the anterior sector,
      thus increasing the functioning hepatocyte mass, and this group initiated dual
      left-lobe liver grafts to overcome both donor risk and volume insufficiency.
      AREAS OF AGREEMENT AND CONTROVERSY: Although the surgical procedures for both
      donors and recipients are more complex for adult LDLT than for whole-organ
      deceased donor transplantation, the outcomes in large-volume centers are now
      similar. Accordingly, the indications for adult LDLT are continually being
      expanded. AREAS TIMELY FOR DEVELOPING RESEARCH: In performing these procedures,
      it is crucial to minimize the risks of morbidity and mortality to the healthy
      live donor. This review focuses on the current technical development and
      discusses the ethical issues of adult LDLT.
FAU - Lee, Sung-Gyu
AU  - Lee SG
AD  - HepatoBiliary Surgery and Liver Transplantation, Asan Medical Center, University 
      of Ulsan College of Medicine, Songpa-gu, Seoul 138-736, Republic of Korea.
      sglee2@amc.seoul.kr
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100208
PL  - England
TA  - Br Med Bull
JT  - British medical bulletin
JID - 0376542
SB  - IM
MH  - Adult
MH  - Donor Selection
MH  - Female
MH  - Humans
MH  - Liver/anatomy & histology
MH  - Liver Transplantation/*methods
MH  - *Living Donors
MH  - Male
MH  - Organ Size
MH  - Practice Guidelines as Topic
MH  - Tissue and Organ Harvesting
RF  - 40
EDAT- 2010/02/11 06:00
MHDA- 2010/10/05 06:00
CRDT- 2010/02/11 06:00
PHST- 2010/02/11 06:00 [entrez]
PHST- 2010/02/11 06:00 [pubmed]
PHST- 2010/10/05 06:00 [medline]
AID - ldq003 [pii]
AID - 10.1093/bmb/ldq003 [doi]
PST - ppublish
SO  - Br Med Bull. 2010;94:33-48. doi: 10.1093/bmb/ldq003. Epub 2010 Feb 8.


PMID- 20144937
OWN - NLM
STAT- MEDLINE
DCOM- 20101001
LR  - 20161125
IS  - 1471-8391 (Electronic)
IS  - 0007-1420 (Linking)
VI  - 94
DP  - 2010
TI  - Non-medical sex selection: ethical issues.
PG  - 7-20
LID - 10.1093/bmb/ldq002 [doi]
AB  - INTRODUCTION: This paper aims to provide a concise review of the ethical issues
      that are commonly raised in the UK debate on non-medical sex selection.
      Background information on sex selection technologies is provided, as is a
      description of the relevant UK legislation. Arguments for and against non-medical
      sex selection will be explained and compared and conclusions will be drawn. It is
      finally suggested that the international debate on non-medical sex selection
      ought to be regarded as an important area of related interest. SOURCES OF DATA:
      Data were obtained from a search of existing ethics and policy literature
      focusing on sex selection. AREAS OF AGREEMENT: There are very few areas of
      universal agreement in the debate. AREAS OF CONTROVERSY: There is much
      disagreement between critics over what harms are likely to be caused by sex
      selection and whether such harms are morally significant. The issue of whether
      governments can legitimately place limitations upon individual reproductive
      autonomy, and if so, to what degree, remains controversial.
FAU - Strange, Heather
AU  - Strange H
AD  - Cardiff University, Cardiff CF10 3BG, UK. StrangeHR1@cardiff.ac.uk
CN  - Cesagen (ESRC centre for economic and social aspects of genomics)
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100209
PL  - England
TA  - Br Med Bull
JT  - British medical bulletin
JID - 0376542
SB  - IM
MH  - Female
MH  - Humans
MH  - Male
MH  - Patient Rights/*ethics
MH  - Reproductive Techniques, Assisted/legislation & jurisprudence
MH  - Sex Preselection/*ethics
MH  - United Kingdom
RF  - 24
EDAT- 2010/02/11 06:00
MHDA- 2010/10/05 06:00
CRDT- 2010/02/11 06:00
PHST- 2010/02/11 06:00 [entrez]
PHST- 2010/02/11 06:00 [pubmed]
PHST- 2010/10/05 06:00 [medline]
AID - ldq002 [pii]
AID - 10.1093/bmb/ldq002 [doi]
PST - ppublish
SO  - Br Med Bull. 2010;94:7-20. doi: 10.1093/bmb/ldq002. Epub 2010 Feb 9.


PMID- 20144893
OWN - NLM
STAT- MEDLINE
DCOM- 20100730
LR  - 20191210
IS  - 1873-3514 (Electronic)
IS  - 0028-3932 (Linking)
VI  - 48
IP  - 6
DP  - 2010 May
TI  - The limits of agency in walking humans.
PG  - 1628-36
LID - 10.1016/j.neuropsychologia.2010.02.005 [doi]
AB  - An important principle of human ethics is that individuals are not responsible
      for actions performed when unconscious. Recent research found that the generation
      of an action and the building of a conscious experience of that action (agency)
      are distinct processes and crucial mechanisms for self-consciousness. Yet,
      previous agency studies have focussed on actions of a finger or hand. Here, we
      investigate how agents consciously monitor actions of the entire body in space
      during locomotion. This was motivated by previous work revealing that (1) a
      fundamental aspect of self-consciousness concerns a single and coherent
      representation of the entire spatially situated body and (2) clinical instances
      of human behaviour without consciousness occur in rare neurological conditions
      such as sleepwalking or epileptic nocturnal wandering. Merging techniques from
      virtual reality, full-body tracking, and cognitive science of conscious action
      monitoring, we report experimental data about consciousness during locomotion in 
      healthy participants. We find that agents consciously monitor the location of
      their entire body and its locomotion only with low precision and report that
      while precision remains low it can be systematically modulated in several
      experimental conditions. This shows that conscious action monitoring in
      locomoting agents can be studied in a fine-grained manner. We argue that the
      study of the mechanisms of agency for a person's full body may help to refine our
      scientific criteria of self-hood and discuss sleepwalking and related conditions 
      as alterations in neural systems encoding motor awareness in walking humans.
CI  - 2010 Elsevier Ltd. All rights reserved.
FAU - Kannape, O A
AU  - Kannape OA
AD  - Laboratory of Cognitive Neuroscience, Brain Mind Institute, Swiss Federal
      Institute of Technology, Station 19, 1015 Lausanne, Switzerland.
FAU - Schwabe, L
AU  - Schwabe L
FAU - Tadi, T
AU  - Tadi T
FAU - Blanke, O
AU  - Blanke O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100208
PL  - England
TA  - Neuropsychologia
JT  - Neuropsychologia
JID - 0020713
SB  - IM
MH  - Adult
MH  - Body Image
MH  - Consciousness/*physiology
MH  - Female
MH  - Humans
MH  - Intention
MH  - Male
MH  - Motion Perception/*physiology
MH  - Photic Stimulation/methods
MH  - Psychological Tests
MH  - Psychomotor Performance/*physiology
MH  - Self Concept
MH  - Space Perception/*physiology
MH  - Unconscious, Psychology
MH  - User-Computer Interface
MH  - Walking/*physiology
MH  - Young Adult
EDAT- 2010/02/11 06:00
MHDA- 2010/07/31 06:00
CRDT- 2010/02/11 06:00
PHST- 2009/11/09 00:00 [received]
PHST- 2010/01/28 00:00 [revised]
PHST- 2010/02/01 00:00 [accepted]
PHST- 2010/02/11 06:00 [entrez]
PHST- 2010/02/11 06:00 [pubmed]
PHST- 2010/07/31 06:00 [medline]
AID - S0028-3932(10)00049-7 [pii]
AID - 10.1016/j.neuropsychologia.2010.02.005 [doi]
PST - ppublish
SO  - Neuropsychologia. 2010 May;48(6):1628-36. doi:
      10.1016/j.neuropsychologia.2010.02.005. Epub 2010 Feb 8.


PMID- 20144817
OWN - NLM
STAT- MEDLINE
DCOM- 20101129
LR  - 20110922
IS  - 1130-6343 (Print)
IS  - 1130-6343 (Linking)
VI  - 34
IP  - 1
DP  - 2010 Jan-Feb
TI  - Role of health-related quality of life measurements in the design of drug
      clinical trials.
PG  - 16-22
LID - 10.1016/j.farma.2009.07.002 [doi]
AB  - OBJECTIVE: Health-related quality of life (HRQL) measurements enable us to take
      patient perception into account when evaluating treatment outcomes from clinical 
      trials (CTs). The purpose of this study was to evaluate the use of HRQL
      questionnaires as a measurement of efficacy in CT design. METHODS: A duplicate
      systematic review of the CTs examined by a Clinical Research Ethics Committee
      between 1995 and 2006 was performed to check for use of HRQL. We gathered data
      concerning general aspects including medical specialty, drugs evaluated,
      methodological quality and inclusion of economic variables. For CTs including
      HRQL measurements, we analysed the type of questionnaire in use. Where there were
      no HRQL measurements, we analysed the methodological possibilities for including 
      them, and the relevance of their absence. RESULTS: A total of 242 CTs were
      analysed; 69 (28.5%) included HRQL measurements, and 10 CTs (4.1%) used them as a
      primary endpoint. Only 22 CTs used more than one questionnaire. Data analysis by 
      therapeutic area showed that HRQL was most commonly studied in the fields of
      rheumatology, urology, psychiatry and oncology. Only 33 CTs included economic
      variables. CONCLUSIONS: Measurements based on clinical parameters are the most
      commonly used means of measuring efficacy. Only a small percentage of CTs take
      the patient's perception of his/her health into account, despite the increasing
      importance given to this parameter. Including HRQL questionnaires in CTs design
      is still far from common.
CI  - Copyright (c) 2009 SEFH. Published by Elsevier Espana. All rights reserved.
FAU - San Miguel, R
AU  - San Miguel R
AD  - Servicio de Farmacia, Complejo Hospitalario de Soria, Soria, Spain.
      rselista@hotmail.com
FAU - del Villar, V
AU  - del Villar V
FAU - Perez, C
AU  - Perez C
FAU - de Frutos, M
AU  - de Frutos M
FAU - Mar, J
AU  - Mar J
FAU - Coma, M J
AU  - Coma MJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100122
PL  - Spain
TA  - Farm Hosp
JT  - Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad
      Espanola de Farmacia Hospitalaria
JID - 9440679
SB  - IM
EIN - Farm Hosp. 2011 Mar-Apr;35(2):100
MH  - Clinical Trials as Topic/*standards
MH  - Humans
MH  - *Quality of Life
MH  - Research Design/*standards
EDAT- 2010/02/11 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/02/11 06:00
PHST- 2009/04/23 00:00 [received]
PHST- 2009/07/23 00:00 [revised]
PHST- 2009/07/27 00:00 [accepted]
PHST- 2010/02/11 06:00 [entrez]
PHST- 2010/02/11 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S1130-6343(09)00011-7 [pii]
AID - 10.1016/j.farma.2009.07.002 [doi]
PST - ppublish
SO  - Farm Hosp. 2010 Jan-Feb;34(1):16-22. doi: 10.1016/j.farma.2009.07.002. Epub 2010 
      Jan 22.


PMID- 20144139
OWN - NLM
STAT- MEDLINE
DCOM- 20100616
LR  - 20161125
IS  - 1473-4877 (Electronic)
IS  - 0300-7995 (Linking)
VI  - 26
IP  - 4
DP  - 2010 Apr
TI  - Challenges of therapeutic substitution of drugs for economic reasons: focus on
      CVD prevention.
PG  - 871-8
LID - 10.1185/03007990903578462 [doi]
AB  - BACKGROUND: Healthcare systems throughout the world are under increasing pressure
      to control and minimise costs. The substitution of initially-prescribed drugs
      with cheaper equivalents is an obvious option which presents a rapid and visible 
      means to reduce these costs. Whether the substitution improves patient and/or
      population outcomes must be appraised and this paper highlights the conditions
      under which therapeutic substitution may require additional thought and
      consideration. SCOPE: In this paper, some of the medical evidence and the
      regulatory environment for and against the three types of therapeutic
      substitution - generic, within-class and between-class - are discussed. This
      article is not an exhaustive review of the literature, but captures some of the
      key clinical, pharmacological, economic, policy and ethical issues regarding
      generic and therapeutic substitution. Search criteria of the most commonly used
      terms, i.e. therapeutic substitution, switching, interchange, and bioequivalence,
      were applied to Embase, PubMed and Google Scholar to identify relevant
      publications. FINDINGS: Although population studies support therapeutic
      substitution in principle, there is evidence that substitution may not always
      result in therapeutic equivalence in individual patients, with the consequent
      potential for greater risks of decreased efficacy and/or increased safety
      concerns. Factors such as patient choice and therapeutic equivalence also play an
      important role in the effectiveness of the treatment and overall management of
      the patient. The pan-European regulatory environment provides another
      contradiction, encouraging widespread cost containment through reduction in drug 
      acquisition costs, while simultaneously promoting an increased role for patients 
      in defining and managing their own treatment. CONCLUSIONS: There is a strong
      rationale for careful management in some patients with cardiovascular disease.
      Treatment decisions should be transparent and based on strong clinical evidence. 
      If not, drug substitution on economic grounds alone cannot be considered to be in
      the individual patient's interest and is therefore unethical.
FAU - Johnston, Atholl
AU  - Johnston A
AD  - Clinical Pharmacology, Barts and The London School of Medicine and Dentistry,
      London, UK. A.Johnston@qmul.ac.uk
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Curr Med Res Opin
JT  - Current medical research and opinion
JID - 0351014
RN  - 0 (Angiotensin II Type 1 Receptor Blockers)
RN  - 0 (Drugs, Generic)
RN  - 0 (Tetrazoles)
RN  - 80M03YXJ7I (Valsartan)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Angiotensin II Type 1 Receptor Blockers/*economics/pharmacokinetics/therapeutic
      use
MH  - Cost Control
MH  - Cost-Benefit Analysis
MH  - Drugs, Generic/*economics/pharmacokinetics/therapeutic use
MH  - Europe
MH  - *Fees, Pharmaceutical
MH  - *Health Care Costs
MH  - Humans
MH  - Hypertension/*drug therapy
MH  - Medication Adherence
MH  - Patient Preference
MH  - Tetrazoles/*economics/pharmacokinetics/therapeutic use
MH  - Therapeutic Equivalency
MH  - United Kingdom
MH  - United States
MH  - Valine/*analogs & derivatives/economics/pharmacokinetics/therapeutic use
MH  - Valsartan
EDAT- 2010/02/11 06:00
MHDA- 2010/06/17 06:00
CRDT- 2010/02/11 06:00
PHST- 2010/02/11 06:00 [entrez]
PHST- 2010/02/11 06:00 [pubmed]
PHST- 2010/06/17 06:00 [medline]
AID - 10.1185/03007990903578462 [doi]
PST - ppublish
SO  - Curr Med Res Opin. 2010 Apr;26(4):871-8. doi: 10.1185/03007990903578462.


PMID- 20144033
OWN - NLM
STAT- MEDLINE
DCOM- 20100524
LR  - 20100210
IS  - 1096-4673 (Electronic)
IS  - 0161-2840 (Linking)
VI  - 31
IP  - 3
DP  - 2010 Mar
TI  - Trauma informed care on an inpatient pediatric psychiatric unit and the emergence
      of ethical dilemmas as nurses evolved their practice.
PG  - 216-22
LID - 10.3109/01612840903315841 [doi]
AB  - Two case studies are presented reflecting the ethical dilemmas experienced by
      nurses who were striving to improve their practice in the provision of patient
      care. The cases are described in the context of finding alternatives to cohesive 
      interventions such as chemical restraints and physical restraints. A summary of
      the literature on ethical dilemmas that was relevant to the issues arising in
      these cases is included. Discussion of the use of the American Nursing
      Association's (ANA, 2001 ) Nursing Code of Ethics with Interpretive Statements is
      highlighted for its relevance and support of the nurses experiencing the ethical 
      dilemmas.
FAU - Regan, Kathleen
AU  - Regan K
AD  - Cambridge Health Alliance, Cambridge, Massachusetts 02193, USA.
      kregan@challiance.org
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Issues Ment Health Nurs
JT  - Issues in mental health nursing
JID - 7907126
RN  - 0 (Psychotropic Drugs)
MH  - Aggression/psychology
MH  - Child
MH  - Child Advocacy/legislation & jurisprudence
MH  - *Ethics, Nursing
MH  - Female
MH  - Humans
MH  - *Life Change Events
MH  - Male
MH  - Massachusetts
MH  - Patient Compliance/psychology
MH  - Psychiatric Department, Hospital/*ethics
MH  - Psychiatric Nursing/*ethics
MH  - Psychotropic Drugs/*administration & dosage
MH  - Restraint, Physical/*ethics
MH  - Stress Disorders, Post-Traumatic/*nursing/psychology
EDAT- 2010/02/11 06:00
MHDA- 2010/05/25 06:00
CRDT- 2010/02/11 06:00
PHST- 2010/02/11 06:00 [entrez]
PHST- 2010/02/11 06:00 [pubmed]
PHST- 2010/05/25 06:00 [medline]
AID - 10.3109/01612840903315841 [doi]
PST - ppublish
SO  - Issues Ment Health Nurs. 2010 Mar;31(3):216-22. doi: 10.3109/01612840903315841.


PMID- 20142674
OWN - NLM
STAT- MEDLINE
DCOM- 20100615
LR  - 20100209
IS  - 1538-8670 (Electronic)
IS  - 0744-6314 (Linking)
VI  - 41
IP  - 2
DP  - 2010 Feb
TI  - Is this ethical? You DECIDE.
PG  - 18-21
LID - 10.1097/01.NUMA.0000368562.74726.9e [doi]
FAU - Elchos, Sarah
AU  - Elchos S
AD  - The Methodist Hospital, Houston, Texas, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Nurs Manage
JT  - Nursing management
JID - 8219243
MH  - *Ethics, Nursing
MH  - Humans
MH  - *Nurse Administrators
MH  - *Patient Care Planning
MH  - Teaching Rounds/methods
EDAT- 2010/02/10 06:00
MHDA- 2010/06/16 06:00
CRDT- 2010/02/10 06:00
PHST- 2010/02/10 06:00 [entrez]
PHST- 2010/02/10 06:00 [pubmed]
PHST- 2010/06/16 06:00 [medline]
AID - 10.1097/01.NUMA.0000368562.74726.9e [doi]
AID - 00006247-201002000-00006 [pii]
PST - ppublish
SO  - Nurs Manage. 2010 Feb;41(2):18-21. doi: 10.1097/01.NUMA.0000368562.74726.9e.


PMID- 20142589
OWN - NLM
STAT- MEDLINE
DCOM- 20100407
LR  - 20220311
IS  - 1527-7755 (Electronic)
IS  - 0732-183X (Linking)
VI  - 28
IP  - 8
DP  - 2010 Mar 10
TI  - Whole-genome profiling of pediatric diffuse intrinsic pontine gliomas highlights 
      platelet-derived growth factor receptor alpha and poly (ADP-ribose) polymerase as
      potential therapeutic targets.
PG  - 1337-44
LID - 10.1200/JCO.2009.25.5463 [doi]
AB  - PURPOSE: Diffuse intrinsic pontine glioma (DIPG) is one of the most devastating
      of pediatric malignancies and one for which no effective therapy exists. A major 
      contributor to the failure of therapeutic trials is the assumption that biologic 
      properties of brainstem tumors in children are identical to cerebral high-grade
      gliomas of adults. A better understanding of the biology of DIPG itself is needed
      in order to develop agents targeted more specifically to these children's
      disease. Herein, we address this lack of knowledge by performing the first
      high-resolution single nucleotide polymorphism (SNP) -based DNA microarray
      analysis of a series of DIPGs. PATIENTS AND METHODS: Eleven samples (nine
      postmortem and two pretreatment surgical samples), the largest series thus far
      examined, were hybridized to SNP arrays (250 k or 6.0). The study was approved by
      the research ethics board at our institution. All array findings were validated
      using quantitative polymerase chain reaction, fluorescence in situ hybridization,
      immunohistochemistry, and/or microsatellite analysis. RESULTS: Analysis of DIPG
      copy number alterations showed recurrent changes distinct from those of pediatric
      supratentorial high-grade astrocytomas. Thirty-six percent of DIPGs had gains in 
      platelet-derived growth factor receptor alpha (PDGFRA; 4 to 18 copies) and all
      showed PDGFR-alpha expression. Low-level gains in poly (ADP-ribose) polymerase
      (PARP) -1 were identified in three cases. Pathway analysis revealed genes with
      loss of heterozygosity were enriched for DNA repair pathways. CONCLUSION: To our 
      knowledge, our data provides the first, comprehensive high-resolution genomic
      analysis of pediatric DIPG. Our findings of recurrent involvement of the PDGFR
      pathway as well as defects in DNA repair pathways coupled with gain of PARP-1
      highlight two potential, biologically based, therapeutic targets directed
      specifically at this devastating disease.
FAU - Zarghooni, Maryam
AU  - Zarghooni M
AD  - Division of Pathology andHaematology, The Labatt Brain Tumor Research Centre, The
      Hospital for Sick Children,Toronto, Ontario, Canada.
FAU - Bartels, Ute
AU  - Bartels U
FAU - Lee, Eric
AU  - Lee E
FAU - Buczkowicz, Pawel
AU  - Buczkowicz P
FAU - Morrison, Andrew
AU  - Morrison A
FAU - Huang, Annie
AU  - Huang A
FAU - Bouffet, Eric
AU  - Bouffet E
FAU - Hawkins, Cynthia
AU  - Hawkins C
LA  - eng
GR  - MOP 82727/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100208
PL  - United States
TA  - J Clin Oncol
JT  - Journal of clinical oncology : official journal of the American Society of
      Clinical Oncology
JID - 8309333
RN  - 0 (DNA, Neoplasm)
RN  - EC 2.4.2.30 (PARP1 protein, human)
RN  - EC 2.4.2.30 (Poly (ADP-Ribose) Polymerase-1)
RN  - EC 2.4.2.30 (Poly(ADP-ribose) Polymerases)
RN  - EC 2.7.10.1 (Receptor, Platelet-Derived Growth Factor alpha)
SB  - IM
MH  - Autopsy
MH  - Brain Stem Neoplasms/*genetics/pathology
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - DNA Repair/genetics
MH  - DNA, Neoplasm/analysis
MH  - Female
MH  - Gene Dosage
MH  - Glioma/*genetics/pathology
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Loss of Heterozygosity
MH  - Male
MH  - Oligonucleotide Array Sequence Analysis
MH  - Poly (ADP-Ribose) Polymerase-1
MH  - Poly(ADP-ribose) Polymerases/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Receptor, Platelet-Derived Growth Factor alpha/*genetics
EDAT- 2010/02/10 06:00
MHDA- 2010/04/08 06:00
CRDT- 2010/02/10 06:00
PHST- 2010/02/10 06:00 [entrez]
PHST- 2010/02/10 06:00 [pubmed]
PHST- 2010/04/08 06:00 [medline]
AID - JCO.2009.25.5463 [pii]
AID - 10.1200/JCO.2009.25.5463 [doi]
PST - ppublish
SO  - J Clin Oncol. 2010 Mar 10;28(8):1337-44. doi: 10.1200/JCO.2009.25.5463. Epub 2010
      Feb 8.


PMID- 20140735
OWN - NLM
STAT- MEDLINE
DCOM- 20100812
LR  - 20211020
IS  - 1437-9813 (Electronic)
IS  - 0179-0358 (Linking)
VI  - 26
IP  - 5
DP  - 2010 May
TI  - LigaSure compared with ligatures and endoclips in experimental appendectomy: how 
      safe is it?
PG  - 539-45
LID - 10.1007/s00383-010-2557-x [doi]
AB  - PURPOSE: The present study aims to compare strength, healing, and inflammation of
      appendiceal stumps closed by LigaSure Precise (Valleylab, Boulder, CO, USA)
      device, ligatures using polyglactin 910 (Vicryl, Ethicon, Edinburgh, UK) and
      endoclips (Ligaclip ERCA, Ethicon, OH, USA), and operation time (OT) in
      experimental appendectomy. METHODS: Forty-eight Sprague-Dawley rats were divided 
      into two (Group A and B). Each group was further subdivided into three subgroups 
      (AS, AC, AL, BS, BC, BL) containing eight rats. Appendectomy was performed and
      stump was closed by ligatures in S, by endoclips in C and by LigaSure in L
      subgroups. OT was recorded. In Group A, cecum bursting pressures (BP) were
      determined instantly after the operation. In Group B, BP, histological
      evaluations, and measurements of collagen contents estimated by the tissue
      hydroxyproline (HPL) level were made on the seventh postoperative day.
      Statistical analyses were performed with Kruskal-Wallis test and Mann-Whitney U
      test. P value was considered significant at less than 0.05. RESULTS: BPs of
      subgroups were comparable on postoperative immediate period and day 7. HPLs and
      OTs were significantly better in L subgroups. BL had the least inflammation.
      CONCLUSION: Better healing, less inflammation, shorter OT, and equal strength
      achieved with LigaSure device comparing with polyglactin 910 ties and endoclips
      in experimental appendectomy is encouraging.
FAU - Elemen, Levent
AU  - Elemen L
AD  - Department of Pediatric Surgery, Medical Faculty, Kocaeli University, Kocaeli,
      Turkey. elemenlevent@hotmail.com
FAU - Yazir, Yusufhan
AU  - Yazir Y
FAU - Tugay, Melih
AU  - Tugay M
FAU - Akay, Alper
AU  - Akay A
FAU - Aydin, Seval
AU  - Aydin S
FAU - Yanar, Karolin
AU  - Yanar K
FAU - Ceylan, Sureyya
AU  - Ceylan S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20100207
PL  - Germany
TA  - Pediatr Surg Int
JT  - Pediatric surgery international
JID - 8609169
RN  - 34346-01-5 (Polyglactin 910)
RN  - RMB44WO89X (Hydroxyproline)
SB  - IM
MH  - Animals
MH  - Appendectomy/*instrumentation
MH  - Hemostasis, Surgical/*instrumentation
MH  - Hydroxyproline/metabolism
MH  - Ligation/instrumentation
MH  - Polyglactin 910
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Statistics, Nonparametric
MH  - Wound Healing/physiology
EDAT- 2010/02/09 06:00
MHDA- 2010/08/13 06:00
CRDT- 2010/02/09 06:00
PHST- 2010/01/14 00:00 [accepted]
PHST- 2010/02/09 06:00 [entrez]
PHST- 2010/02/09 06:00 [pubmed]
PHST- 2010/08/13 06:00 [medline]
AID - 10.1007/s00383-010-2557-x [doi]
PST - ppublish
SO  - Pediatr Surg Int. 2010 May;26(5):539-45. doi: 10.1007/s00383-010-2557-x. Epub
      2010 Feb 7.


PMID- 20140538
OWN - NLM
STAT- MEDLINE
DCOM- 20100803
LR  - 20211020
IS  - 1556-0961 (Electronic)
IS  - 1541-6933 (Linking)
VI  - 12
IP  - 3
DP  - 2010 Jun
TI  - Sperm retrieval during critical illness.
PG  - 445-9
LID - 10.1007/s12028-010-9333-6 [doi]
AB  - Objective of this study is to review technical methods to retrieve sperm from
      critically ill/injured patients after an appropriate family request, possible
      harmful effects on sperm production/function by ICU medications or concurrent
      illnesses, and ethical considerations for hospitals and care providers in
      providing this resource. Design used for this study includes: literature review, 
      PubMed 1998-2009, and authors' files. There are no interventions. In conclusion, 
      although successful and unsuccessful pregnancies following sperm removal from
      critically-ill patients are reported, no firm probability predictions for either 
      result are known. Acute and chronic diseases that effect the
      hypothalamic-pituitary-gonadal axis and multiple medications common to the ICU
      may reduce sperm production or function. Retrieval methods before and after
      cardio-respiratory death differ and often require intracytoplasmic sperm
      injection or other in vitro fertilization techniques to achieve a subsequent
      pregnancy. The proactive development of a collaborative policy/procedure to
      identify appropriate roles for the hospital, its employees, and affiliated
      critical care and urology physicians is strongly recommended.
FAU - Powner, David J
AU  - Powner DJ
AD  - Departments of Neurosurgery and Internal Medicine, University of Texas Health
      Sciences Center at Houston Medical School, 6431 Fannin Street, MSB 7.154,
      Houston, TX 77030, USA. david.j.powner@uth.tmc.edu
FAU - Rumohr, Jon A
AU  - Rumohr JA
FAU - Lipshultz, Larry I
AU  - Lipshultz LI
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Neurocrit Care
JT  - Neurocritical care
JID - 101156086
SB  - IM
MH  - Brain Death/physiopathology
MH  - Cooperative Behavior
MH  - Critical Care/ethics
MH  - *Critical Illness
MH  - Ethics, Medical
MH  - Female
MH  - Fertilization in Vitro/ethics
MH  - Humans
MH  - Informed Consent/ethics/legislation & jurisprudence
MH  - Interdisciplinary Communication
MH  - Male
MH  - Patient Care Team
MH  - Pregnancy
MH  - Semen Analysis/ethics
MH  - Sperm Injections, Intracytoplasmic/ethics
MH  - *Sperm Retrieval/ethics
MH  - Spermatogenesis/drug effects/physiology
MH  - Treatment Outcome
EDAT- 2010/02/09 06:00
MHDA- 2010/08/04 06:00
CRDT- 2010/02/09 06:00
PHST- 2010/02/09 06:00 [entrez]
PHST- 2010/02/09 06:00 [pubmed]
PHST- 2010/08/04 06:00 [medline]
AID - 10.1007/s12028-010-9333-6 [doi]
PST - ppublish
SO  - Neurocrit Care. 2010 Jun;12(3):445-9. doi: 10.1007/s12028-010-9333-6.


PMID- 20140344
OWN - NLM
STAT- MEDLINE
DCOM- 20100803
LR  - 20190606
IS  - 1518-8787 (Electronic)
IS  - 0034-8910 (Linking)
VI  - 44
IP  - 1
DP  - 2010 Feb
TI  - Knowledge industry: a powerful mechanism.
PG  - 190-6
LID - S0034-89102010000100021 [pii]
AB  - The paper deals with the pharmaceutical industry's links to the knowledge
      industry, through powerful marketing strategies. With the aim of scientifically
      legitimizing its products, the pharmaceutical industry interferes with the
      production of medical knowledge. In the form of a mechanism for directing
      economic interests, it funds drug research, biases its results and stimulates the
      production and publication of scientific papers. This is a mechanism that
      threatens important ethical issues: it transforms the process of scientific
      legitimization into a marketing strategy, compromises the credibility of the
      process of constructing medical knowledge and encourages distortions of the
      criteria for evaluating the quality of scientific papers.
FAU - Miguelote, Vera Regina da Silva
AU  - Miguelote VR
AD  - Departamento de Planejamento, Politicas e Administracao em Saude, Instituto de
      Medicina Social, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ,
      Brasil. veramiguelote@terra.com.br
FAU - Camargo, Kenneth Rochel de Jr
AU  - Camargo KR Jr
LA  - eng
LA  - por
PT  - Journal Article
PL  - Brazil
TA  - Rev Saude Publica
JT  - Revista de saude publica
JID - 0135043
SB  - IM
MH  - Biomedical Research/economics/*ethics
MH  - *Conflict of Interest
MH  - *Diffusion of Innovation
MH  - Drug Industry/economics/*ethics
MH  - Female
MH  - Humans
MH  - Information Dissemination/*ethics
MH  - Male
MH  - Marketing
EDAT- 2010/02/09 06:00
MHDA- 2010/08/04 06:00
CRDT- 2010/02/09 06:00
PHST- 2008/12/02 00:00 [received]
PHST- 2009/09/24 00:00 [accepted]
PHST- 2010/02/09 06:00 [entrez]
PHST- 2010/02/09 06:00 [pubmed]
PHST- 2010/08/04 06:00 [medline]
AID - S0034-89102010000100021 [pii]
AID - 10.1590/s0034-89102010000100021 [doi]
PST - ppublish
SO  - Rev Saude Publica. 2010 Feb;44(1):190-6. doi: 10.1590/s0034-89102010000100021.


PMID- 20140342
OWN - NLM
STAT- MEDLINE
DCOM- 20100803
LR  - 20190606
IS  - 1518-8787 (Electronic)
IS  - 0034-8910 (Linking)
VI  - 44
IP  - 1
DP  - 2010 Feb
TI  - Actions of health group coordinators within the teaching/care network.
PG  - 177-84
LID - S0034-89102010000100019 [pii]
AB  - OBJECTIVE: To analyze the model for actions by health promotion group
      coordinators, in primary healthcare units with links to professional training.
      METHODOLOGICAL PROCEDURES: A qualitative study was carried out in the
      municipality of Florianopolis, Southern Brazil, in 2001. Four groups were
      evaluated, over a total of 24 sessions at primary healthcare units. Participant
      observation was performed to start the fieldwork. The reports were analyzed by
      means of the technique of enunciative-pragmatic discourse analysis. ANALYSIS OF
      RESULTS: The types of action among the coordinators that were congruent with the 
      preventive model were: oppression, bench teaching, biologism and higienism,
      prescription of approaches, blame apportionment, infantilization, reduction of
      collective problems, denigration of group settings and use of monologue. The
      types of action consonant with the new promotion model were: facilitation of free
      expression and autonomy, empathetic communication, constructivism, receptiveness,
      active listening and promotion of overcoming of violence and alienation.
      CONCLUSIONS: The coordinators acted primarily by means of the preventive model,
      without using technical and theoretical resources that allude to group
      methodology in the field of healthcare. The actions within the preventive and new
      health promotion models that were identified reveal characteristics that are
      grounded in, respectively, the ethics of oppression/subordination of users and
      cooperation/acceptance of users as free and responsible for their choices and
      consequences.
FAU - Santos, Luciane de Medeiros dos
AU  - Santos Lde M
AD  - Centro de Estudos do Envelhecimento, Universidade Federal de Sao Paulo, Sao
      Paulo, SP, Brasil. lucianems@terra.com.br
FAU - Oliveira, Eleonora Menicucci de
AU  - Oliveira EM
FAU - Crepaldi, Maria Aparecida
AU  - Crepaldi MA
FAU - Da Ros, Marco Aurelio
AU  - Da Ros MA
LA  - eng
LA  - por
PT  - Journal Article
PL  - Brazil
TA  - Rev Saude Publica
JT  - Revista de saude publica
JID - 0135043
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Brazil
MH  - *Health Promotion/organization & administration
MH  - *Humanism
MH  - Humans
MH  - Primary Health Care/*organization & administration
MH  - Program Evaluation
MH  - Qualitative Research
MH  - Workforce
EDAT- 2010/02/09 06:00
MHDA- 2010/08/04 06:00
CRDT- 2010/02/09 06:00
PHST- 2007/08/31 00:00 [received]
PHST- 2009/10/14 00:00 [accepted]
PHST- 2010/02/09 06:00 [entrez]
PHST- 2010/02/09 06:00 [pubmed]
PHST- 2010/08/04 06:00 [medline]
AID - S0034-89102010000100019 [pii]
AID - 10.1590/s0034-89102010000100019 [doi]
PST - ppublish
SO  - Rev Saude Publica. 2010 Feb;44(1):177-84. doi: 10.1590/s0034-89102010000100019.


PMID- 20138733
OWN - NLM
STAT- MEDLINE
DCOM- 20100803
LR  - 20131121
IS  - 1769-6623 (Electronic)
IS  - 0750-7658 (Linking)
VI  - 29
IP  - 4
DP  - 2010 Apr
TI  - [Flexible laryngeal mask airway use during surgical burn management with head
      mobilisation: a feasibility study].
PG  - 269-73
LID - 10.1016/j.annfar.2009.10.024 [doi]
AB  - OBJECTIVE: To evaluate the feasibility and reliability of the flexible laryngeal 
      mask airway (LMA flexible) use during scalp skin harvesting for surgical
      reparation of burn sequella. STUDY DESIGN: Observational prospective descriptive 
      study. PATIENTS AND METHODS: Following local ethic committee approval, 26
      patients were included in the study during their preanaesthesia visit. The
      general anaesthesia induction of each patient was followed by the insertion of a 
      LMA flexible. The number of attempts required to insert the mask and the
      procedure were documented. The oropharyngeal leak pressure, expired tidal volume 
      and end tidal CO(2) were recorded in five different head positions (neutral,
      hyperflexion, hyperextension, right and left rotation) at the start and end of
      surgical procedure. In all ten study periods of 2-3 min each were evaluated.
      RESULTS: The airway device was inserted easily in all patients. While similar in 
      four of the five head positions (neutral: 27.9+/-8.1 cmH(2)O, hyperextension,
      left and right rotation), the oropharyngeal leak pressure was significantly
      higher in the hyperflexion position (33.3+/-7.3 cmH(2)O). The end tidal volume
      was stable in all positions except hyperflexion (419+/-114 ml). While this value 
      was significantly lower than the 471+/-68 ml recorded in the neutral position, it
      remained greater than 7 ml/kg. No significant change was observed for end tidal
      CO(2) for the ten study periods. CONCLUSION: The use of LMA flexible during
      surgical burn repair procedures, including head mobilisation for the harvesting
      of scalp skin grafts is feasible.
CI  - Copyright 2010 Elsevier Masson SAS. All rights reserved.
FAU - Sebbane, M
AU  - Sebbane M
AD  - Structure des urgences, hopital Lapeyronie, 191, avenue du Doyen-Gaston-Giraud,
      CHRU de Montpellier, 34295 Montpellier, France. m-sebbane@chu-montpellier.fr
FAU - Chanques, G
AU  - Chanques G
FAU - Cisse, M
AU  - Cisse M
FAU - Lebreton, F
AU  - Lebreton F
FAU - Brabet, M
AU  - Brabet M
FAU - Gartner, R
AU  - Gartner R
FAU - Rubenovitch, J
AU  - Rubenovitch J
FAU - Eledjam, J-J
AU  - Eledjam JJ
FAU - Jaber, S
AU  - Jaber S
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Interet du masque larynge renforce au cours de la chirurgie reparatrice chez les 
      patients brules necessitant une mobilisation de la tete : etude de faisabilite.
DEP - 20100206
PL  - France
TA  - Ann Fr Anesth Reanim
JT  - Annales francaises d'anesthesie et de reanimation
JID - 8213275
RN  - 142M471B3J (Carbon Dioxide)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Air Pressure
MH  - Anesthesia
MH  - Burns/*surgery
MH  - Carbon Dioxide/blood
MH  - Feasibility Studies
MH  - Female
MH  - Head/*physiology
MH  - Humans
MH  - *Laryngeal Masks
MH  - Male
MH  - Middle Aged
MH  - Posture
MH  - Preanesthetic Medication
MH  - Scalp/*surgery
MH  - Skin Transplantation
MH  - Tidal Volume
MH  - Young Adult
EDAT- 2010/02/09 06:00
MHDA- 2010/08/04 06:00
CRDT- 2010/02/09 06:00
PHST- 2009/05/06 00:00 [received]
PHST- 2009/10/15 00:00 [accepted]
PHST- 2010/02/09 06:00 [entrez]
PHST- 2010/02/09 06:00 [pubmed]
PHST- 2010/08/04 06:00 [medline]
AID - S0750-7658(09)00670-4 [pii]
AID - 10.1016/j.annfar.2009.10.024 [doi]
PST - ppublish
SO  - Ann Fr Anesth Reanim. 2010 Apr;29(4):269-73. doi: 10.1016/j.annfar.2009.10.024.
      Epub 2010 Feb 6.


PMID- 20138555
OWN - NLM
STAT- MEDLINE
DCOM- 20110131
LR  - 20161125
IS  - 1532-2971 (Electronic)
IS  - 1090-0233 (Linking)
VI  - 186
IP  - 2
DP  - 2010 Nov
TI  - Thoughts on the ethics of preventing and controlling epizootic diseases.
PG  - 127-8
LID - 10.1016/j.tvjl.2009.12.028 [doi]
FAU - Wright, N
AU  - Wright N
AD  - Centre for Applied Bioethics, School of Biosciences, Veterinary Medicine and
      Science Building, Sutton Bonington Campus, University of Nottingham, LE12 5RD,
      UK.
FAU - Meijboom, F L B
AU  - Meijboom FL
FAU - Sandoe, P
AU  - Sandoe P
LA  - eng
PT  - Journal Article
DEP - 20100206
PL  - England
TA  - Vet J
JT  - Veterinary journal (London, England : 1997)
JID - 9706281
SB  - IM
MH  - Advisory Committees/organization & administration
MH  - Animal Welfare/*ethics/organization & administration
MH  - Animals
MH  - Cattle
MH  - Disease Outbreaks/ethics/prevention & control/*veterinary
MH  - Encephalopathy, Bovine Spongiform/epidemiology/*prevention & control
MH  - Foot-and-Mouth Disease/epidemiology/*prevention & control
MH  - United Kingdom/epidemiology
EDAT- 2010/02/09 06:00
MHDA- 2011/02/01 06:00
CRDT- 2010/02/09 06:00
PHST- 2009/12/23 00:00 [received]
PHST- 2009/12/23 00:00 [accepted]
PHST- 2010/02/09 06:00 [entrez]
PHST- 2010/02/09 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
AID - S1090-0233(09)00517-6 [pii]
AID - 10.1016/j.tvjl.2009.12.028 [doi]
PST - ppublish
SO  - Vet J. 2010 Nov;186(2):127-8. doi: 10.1016/j.tvjl.2009.12.028. Epub 2010 Feb 6.


PMID- 20138274
OWN - NLM
STAT- MEDLINE
DCOM- 20100716
LR  - 20220317
IS  - 1879-3479 (Electronic)
IS  - 0020-7292 (Linking)
VI  - 109
IP  - 2
DP  - 2010 May
TI  - The issue of reinfibulation.
PG  - 93-6
LID - 10.1016/j.ijgo.2010.01.001 [doi]
AB  - Reinfibulation is resuturing after delivery or gynecological procedures of the
      incised scar tissue resulting from infibulation. Despite the global fight against
      female genital mutilation/cutting (FGM/C), reinfibulation of previously mutilated
      or circumcised women is still performed in various countries around the world. A 
      good estimate of the prevalence of reinfibulation is difficult to obtain, but it 
      can be inferred that 6.5-10.4million women are likely to have been reinfibulated 
      worldwide. Women who undergo reinfibulation have little influence on the
      decision-making and are usually persuaded by the midwife or birth attendant to
      undergo the procedure immediately following labor or gynecological operation.
      Although medicalization of reinfibulation may reduce its immediate risks, it has 
      no effect on the incidence of long-term risks. Reinfibulation is performed mainly
      for the financial benefit of the operator, and cultural values that have been
      perpetuated for generations. Reinfibulation has no benefits and is associated
      with complications for the woman and the unborn child. Its medicalization
      violates the medical code of ethics and should be abandoned. International and
      national efforts should be combined to eradicate this practice.
CI  - Copyright 2010 International Federation of Gynecology and Obstetrics. Published
      by Elsevier Ireland Ltd. All rights reserved.
FAU - Serour, Gamal I
AU  - Serour GI
AD  - Department of Obstetrics and Gynecology, International Islamic Center for
      Population Studies and Research, Al Azhar University, Cairo, Egypt.
      giserour1@link.net
LA  - eng
PT  - Journal Article
DEP - 20100206
PL  - United States
TA  - Int J Gynaecol Obstet
JT  - International journal of gynaecology and obstetrics: the official organ of the
      International Federation of Gynaecology and Obstetrics
JID - 0210174
SB  - IM
MH  - Adolescent
MH  - Child
MH  - *Circumcision, Female/ethics/ethnology
MH  - Contraindications
MH  - Cultural Characteristics
MH  - Ethics, Medical
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - *Human Rights Abuses
MH  - Humans
MH  - Prevalence
MH  - Religion and Medicine
MH  - *Women's Health
MH  - Young Adult
EDAT- 2010/02/09 06:00
MHDA- 2010/07/17 06:00
CRDT- 2010/02/09 06:00
PHST- 2009/09/16 00:00 [received]
PHST- 2010/01/04 00:00 [revised]
PHST- 2010/01/11 00:00 [accepted]
PHST- 2010/02/09 06:00 [entrez]
PHST- 2010/02/09 06:00 [pubmed]
PHST- 2010/07/17 06:00 [medline]
AID - S0020-7292(10)00010-X [pii]
AID - 10.1016/j.ijgo.2010.01.001 [doi]
PST - ppublish
SO  - Int J Gynaecol Obstet. 2010 May;109(2):93-6. doi: 10.1016/j.ijgo.2010.01.001.
      Epub 2010 Feb 6.


PMID- 20137826
OWN - NLM
STAT- MEDLINE
DCOM- 20101124
LR  - 20211020
IS  - 1872-6054 (Electronic)
IS  - 0168-8510 (Linking)
VI  - 96
IP  - 2
DP  - 2010 Jul
TI  - Pandemic planning in pediatric care: a website policy review and national survey 
      data.
PG  - 134-42
LID - 10.1016/j.healthpol.2010.01.007 [doi]
AB  - OBJECTIVES: This study investigates current policies, key issues, and needs for
      pandemic planning in pediatrics in Canada. METHODS: Online pandemic plans from
      national, provincial and territorial government websites were reviewed to
      identify: plans for children and families, and psychosocial and ethical issues. A
      survey was administered to gather participants' perspectives on the needs in
      pediatric planning, as well as important elements of their organizations' and
      regions' pandemic plans. A thematic analysis was conducted on qualitative survey 
      responses. RESULTS: The majority of existing plans did not adequately address the
      unique needs of pediatric populations, and mainly focused on medical and policy
      concerns. Several gaps in plans were identified, including the need for
      psychosocial supports and ethical decision-making frameworks for children and
      families. Similarly, survey respondents identified parallel gaps, in their
      organization's or region's plans. CONCLUSIONS: Although many plans provide
      guidelines for medical and policy issues in pediatrics, much more work remains in
      psychosocial and ethical planning. A focus on children and families is needed for
      pandemic planning in pediatrics to ensure best outcomes for children and
      families.
CI  - Copyright (c) 2010. Published by Elsevier Ireland Ltd.
FAU - Nicholas, David
AU  - Nicholas D
AD  - Faculty of Social Work (Central and Northern Alberta Region), University of
      Calgary, #444 11044-82 Avenue, Edmonton, Alberta, Canada. nicholas@ucalgary.ca
FAU - Patershuk, Clare
AU  - Patershuk C
FAU - Koller, Donna
AU  - Koller D
FAU - Bruce-Barrett, Cindy
AU  - Bruce-Barrett C
FAU - Lach, Lucy
AU  - Lach L
FAU - Zlotnik Shaul, Randi
AU  - Zlotnik Shaul R
FAU - Matlow, Anne
AU  - Matlow A
LA  - eng
GR  - 83144/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Health Policy
JT  - Health policy (Amsterdam, Netherlands)
JID - 8409431
MH  - Canada
MH  - Child
MH  - Community Health Planning/*organization & administration
MH  - Data Collection
MH  - Disaster Planning/*organization & administration
MH  - Family
MH  - Guidelines as Topic
MH  - Humans
MH  - Internet
MH  - Pandemics/*prevention & control
MH  - Pediatrics/*standards
MH  - Public Policy
PMC - PMC7132461
EDAT- 2010/02/09 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/02/09 06:00
PHST- 2009/09/22 00:00 [received]
PHST- 2010/01/07 00:00 [revised]
PHST- 2010/01/11 00:00 [accepted]
PHST- 2010/02/09 06:00 [entrez]
PHST- 2010/02/09 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S0168-8510(10)00022-9 [pii]
AID - 10.1016/j.healthpol.2010.01.007 [doi]
PST - ppublish
SO  - Health Policy. 2010 Jul;96(2):134-42. doi: 10.1016/j.healthpol.2010.01.007.


PMID- 20137023
OWN - NLM
STAT- MEDLINE
DCOM- 20100430
LR  - 20211020
IS  - 1744-6198 (Electronic)
IS  - 0029-6473 (Linking)
VI  - 45
IP  - 1
DP  - 2010 Jan-Mar
TI  - Economic theory and nursing administration research--is this a good combination?
PG  - 40-53
LID - 10.1111/j.1744-6198.2009.00160.x [doi]
AB  - TOPIC: Economic theory is used to describe and explain decision making in the
      context of scarce resources. PURPOSE: This paper presents two applications of
      economic theory to the delivery of nursing services in acute care hospitals and
      evaluates its usefulness in guiding nursing administration research. SOURCES OF
      INFORMATION: The description of economic theory and the proposed applications for
      nursing are based on current nursing, healthcare, and economic literature.
      Evaluation of the potential usefulness of economic theory in guiding nursing
      administration research is based on the criteria of significance and testability 
      as described by Fawcett and Downs. CONCLUSIONS: While economic theory can be very
      useful in explaining how decisions about nursing time allocation and nursing care
      production are made, it will not address the issue of how they should be made.
      Normative theories and ethical frameworks also must be incorporated in the
      decision-making process around these issues. Economic theory and nursing
      administration are a good fit when balanced with the values and goals of nursing.
FAU - Jones, Terry L
AU  - Jones TL
AD  - The University of Texas at Austin, Dallas, TX, USA. tjones0222@aol.com
FAU - Yoder, Linda
AU  - Yoder L
LA  - eng
GR  - KL2 RR024983/RR/NCRR NIH HHS/United States
GR  - UL1 RR024982/RR/NCRR NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Nurs Forum
JT  - Nursing forum
JID - 0401006
MH  - Cost-Benefit Analysis
MH  - Decision Making, Organizational
MH  - Delivery of Health Care/ethics/organization & administration
MH  - Health Care Rationing
MH  - Humans
MH  - Marketing
MH  - *Models, Economic
MH  - *Models, Nursing
MH  - Nursing Administration Research/*organization & administration
MH  - Nursing Service, Hospital/ethics/*organization & administration
MH  - Patient Satisfaction
MH  - Philosophy, Nursing
MH  - Research Design
PMC - PMC5520799
MID - NIHMS879113
EDAT- 2010/02/09 06:00
MHDA- 2010/05/01 06:00
CRDT- 2010/02/09 06:00
PHST- 2010/02/09 06:00 [entrez]
PHST- 2010/02/09 06:00 [pubmed]
PHST- 2010/05/01 06:00 [medline]
AID - NUF160 [pii]
AID - 10.1111/j.1744-6198.2009.00160.x [doi]
PST - ppublish
SO  - Nurs Forum. 2010 Jan-Mar;45(1):40-53. doi: 10.1111/j.1744-6198.2009.00160.x.


PMID- 20137022
OWN - NLM
STAT- MEDLINE
DCOM- 20100430
LR  - 20141120
IS  - 1744-6198 (Electronic)
IS  - 0029-6473 (Linking)
VI  - 45
IP  - 1
DP  - 2010 Jan-Mar
TI  - Immunizing children who fear and resist needles: is it a problem for nurses?
PG  - 29-39
LID - 10.1111/j.1744-6198.2009.00161.x [doi]
AB  - BACKGROUND: Despite increasing evidence that immunization procedures can be
      stressful for children, little is known about what the experience of immunizing
      frightened and needle-resistant children can be like for nurses. METHOD: This
      article presents findings from a qualitative research project designed to explore
      public health nurses' feelings toward immunizing needle-resistant children. A
      constructivist theoretical perspective and an action research approach framed the
      study. Data sources included two survey questions and audio-recorded transcribed 
      data from three focus groups. Participants included 35 public health nurses from 
      five different health units in one Canadian province. The data were analyzed for 
      themes and were confirmed with participants through ongoing member checking.
      RESULTS: The following four overarching themes were identified and are used to
      explain and describe significant features of the immunization experience that
      were stressful and problematic for nurses: (a) nurses experience stress when
      immunizing children who fear and resist needle injection; (b) the strength of
      child resistance and some adult behavior creates an ethical dilemma for nurses;
      (c) some adult responses make immunizing difficult and unsafe; and (d) resources 
      to help nurses cope with these situations are inconsistent.
FAU - Ives, Mary
AU  - Ives M
AD  - Chilliwack Health Unit, Chilliwack, British Columbia, Canada.
      Mary.Ives@fraserhealth.ca
FAU - Melrose, Sherri
AU  - Melrose S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Nurs Forum
JT  - Nursing forum
JID - 0401006
MH  - Adaptation, Psychological
MH  - *Attitude of Health Personnel
MH  - *Attitude to Health
MH  - Canada
MH  - Child
MH  - Child Advocacy
MH  - Child, Preschool
MH  - Clinical Competence
MH  - *Fear
MH  - Focus Groups
MH  - Humans
MH  - Needles/adverse effects
MH  - Nursing Methodology Research
MH  - Nursing Staff/education/*psychology
MH  - Parents/education/psychology
MH  - Psychology, Child
MH  - Public Health Nursing/education/*methods
MH  - Qualitative Research
MH  - Restraint, Physical
MH  - Self Efficacy
MH  - Stress, Psychological/prevention & control/psychology
MH  - *Vaccination/adverse effects/nursing/psychology
EDAT- 2010/02/09 06:00
MHDA- 2010/05/01 06:00
CRDT- 2010/02/09 06:00
PHST- 2010/02/09 06:00 [entrez]
PHST- 2010/02/09 06:00 [pubmed]
PHST- 2010/05/01 06:00 [medline]
AID - NUF161 [pii]
AID - 10.1111/j.1744-6198.2009.00161.x [doi]
PST - ppublish
SO  - Nurs Forum. 2010 Jan-Mar;45(1):29-39. doi: 10.1111/j.1744-6198.2009.00161.x.


PMID- 20136823
OWN - NLM
STAT- MEDLINE
DCOM- 20100505
LR  - 20100208
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 24
IP  - 3
DP  - 2010 Mar
TI  - 'Vague Oviedo': autonomy, culture and the case of previously competent patients.
PG  - 145-52
LID - 10.1111/j.1467-8519.2009.01791.x [doi]
AB  - The paper examines the ethical and legal challenges of making decisions for
      previously competent patients and the role of advance directives and legal
      representatives in light of the Oviedo Convention. The paper identifies gaps in
      the Convention that result in conflicting instructions in cases of a disagreement
      between the expressed prior wishes of a patient, and the legal representative.
      The authors also examine the legal and moral status of informally expressed prior
      wishes of patients unable to consent. The authors argue that positivist legal
      reasoning is insufficient for a consistent interpretation of the relevant
      provisions of the Convention and argue that ethical argumentation is needed to
      provide guidance in such cases. Based on the ethical arguments, the authors
      propose a way of reconciling the apparent inconsistencies in the Oviedo
      Convention. They advance a culturally sensitive approach to the application of
      the Convention at the national level. This approach understands autonomy as a
      broader, relational consent and emphasizes the social and cultural embeddedness
      of the individual. Based on their approach, the authors argue that there exists a
      moral obligation to respect the prior wishes of the patient even in countries
      without advance directives. Yet it should be left to the national legislations to
      determine the extent of this obligation and its concrete forms.
FAU - Pascalev, Assya
AU  - Pascalev A
AD  - Department of Community and Family Medicine, College of Medicine, Howard
      University, 500 W Street NW, Washington, DC 20059, USA. director@bio-ethics.net
FAU - Vidalis, Takis
AU  - Vidalis T
LA  - eng
PT  - Journal Article
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Advance Directives/ethics/*legislation & jurisprudence
MH  - *Cultural Diversity
MH  - Europe
MH  - Humans
MH  - Informed Consent/ethics/*legislation & jurisprudence
MH  - *International Cooperation
MH  - Moral Obligations
MH  - *Proxy
MH  - Terminal Care/ethics/*legislation & jurisprudence
EDAT- 2010/02/09 06:00
MHDA- 2010/05/06 06:00
CRDT- 2010/02/09 06:00
PHST- 2010/02/09 06:00 [entrez]
PHST- 2010/02/09 06:00 [pubmed]
PHST- 2010/05/06 06:00 [medline]
AID - BIOT1791 [pii]
AID - 10.1111/j.1467-8519.2009.01791.x [doi]
PST - ppublish
SO  - Bioethics. 2010 Mar;24(3):145-52. doi: 10.1111/j.1467-8519.2009.01791.x.


PMID- 20136818
OWN - NLM
STAT- MEDLINE
DCOM- 20100505
LR  - 20100208
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 24
IP  - 3
DP  - 2010 Mar
TI  - End-of-life care in the 21st century: advance directives in universal rights
      discourse.
PG  - 105-12
LID - 10.1111/j.1467-8519.2010.01806.x [doi]
AB  - This article explores universal normative bases that could help to shape a
      workable legal construct that would facilitate a global use of advance
      directives. Although I believe that advance directives are of universal
      character, my primary aim in approaching this issue is to remain realistic. I
      will make three claims. First, I will argue that the principles of autonomy,
      dignity and informed consent, embodied in the Oviedo Convention and the UNESCO
      Declaration on Bioethics and Human Rights, could arguably be regarded as
      universal bases for the global use of advance directives. Second, I will
      demonstrate that, despite the apparent consensus of ethical authorities in
      support of their global use, it is unlikely, for the time being, that such
      consensus could lead to unqualified legal recognition of advance directives,
      because of different understandings of the nature of the international rules,
      meanings of autonomy and dignity which are context-specific and culture-specific,
      and existing imperfections that make advance directives either unworkable or
      hardly applicable in practice. The third claim suggests that the fact that the
      concept of the advance directive is not universally shared does not mean that it 
      should not become so, but never as the only option in managing incompetent
      patients. A way to proceed is to prioritize work on developing higher standards
      in managing incompetent patients and on progressing towards the realization of
      universal human rights in the sphere of bioethics, by advocating a universal,
      legally binding international convention that would outlaw human rights
      violations in end-of-life decision-making.
FAU - Besirevic, Violeta
AU  - Besirevic V
AD  - Union University Law School Belgrade, Belgrade, Goce Delceva 36, Serbia.
      besirevv@ceu.hu
LA  - eng
PT  - Journal Article
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Advance Directives/ethics/*legislation & jurisprudence
MH  - Consensus
MH  - Cultural Diversity
MH  - *Human Rights
MH  - Humans
MH  - Informed Consent
MH  - *International Cooperation
MH  - Personal Autonomy
MH  - Personhood
MH  - *Policy Making
MH  - United Nations
EDAT- 2010/02/09 06:00
MHDA- 2010/05/06 06:00
CRDT- 2010/02/09 06:00
PHST- 2010/02/09 06:00 [entrez]
PHST- 2010/02/09 06:00 [pubmed]
PHST- 2010/05/06 06:00 [medline]
AID - BIOT1806 [pii]
AID - 10.1111/j.1467-8519.2010.01806.x [doi]
PST - ppublish
SO  - Bioethics. 2010 Mar;24(3):105-12. doi: 10.1111/j.1467-8519.2010.01806.x.


PMID- 20136808
OWN - NLM
STAT- MEDLINE
DCOM- 20100423
LR  - 20100208
IS  - 1440-1584 (Electronic)
IS  - 1038-5282 (Linking)
VI  - 18
IP  - 1
DP  - 2010 Feb
TI  - Ethics and trauma: lessons from media coverage of Black Saturday.
PG  - 5-10
LID - 10.1111/j.1440-1584.2009.01117.x [doi]
FAU - Muller, Denis
AU  - Muller D
AD  - Centre for Applied Philosophy and Public Ethics, University of Melbourne,
      Melbourne, Victoria, Australia. dmuller@unimelb.edu.au
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Aust J Rural Health
JT  - The Australian journal of rural health
JID - 9305903
MH  - Australia
MH  - *Disasters
MH  - Emotions
MH  - *Fires
MH  - Humans
MH  - Mass Casualty Incidents/*ethics
MH  - Mass Media/*ethics
MH  - Survivors/psychology
MH  - *Wounds and Injuries
EDAT- 2010/02/09 06:00
MHDA- 2010/04/24 06:00
CRDT- 2010/02/09 06:00
PHST- 2010/02/09 06:00 [entrez]
PHST- 2010/02/09 06:00 [pubmed]
PHST- 2010/04/24 06:00 [medline]
AID - AJR1117 [pii]
AID - 10.1111/j.1440-1584.2009.01117.x [doi]
PST - ppublish
SO  - Aust J Rural Health. 2010 Feb;18(1):5-10. doi: 10.1111/j.1440-1584.2009.01117.x.


PMID- 20136743
OWN - NLM
STAT- MEDLINE
DCOM- 20100910
LR  - 20171116
IS  - 1539-6924 (Electronic)
IS  - 0272-4332 (Linking)
VI  - 30
IP  - 2
DP  - 2010 Feb
TI  - Risk management and the wisdom of Aldo Leopold.
PG  - 165-74
LID - 10.1111/j.1539-6924.2009.01348.x [doi]
AB  - Human demands on nature have increased due to our burgeoning population. The
      applications of scientific knowledge to the development of increasingly powerful 
      technologies and consumptive lifestyles by more and more people have created a
      modern category of human-caused disaster-stealth disasters. Stealth
      disasters-such as agriculturally-induced soil erosion and release of
      unprecedented amounts of greenhouse gases into Earth's atmosphere-tend to have
      protracted, unobvious onsets; do not necessarily have dramatic manifestations;
      and often do not attract public attention until they reach a stage approaching
      catastrophic consequences. At this late stage it is difficult or impossible to
      undo damage. Scientists tend to be among the first to understand the physical
      causes and notice the developments of stealth disasters and their risks and yet
      scientific knowledge is not enough to prevent or mitigate them. As we search for 
      ways to deal with stealth disasters, the concept of "land health" assembled by
      the prominent conservationist and author, Aldo Leopold (1887-1948), can, in
      normative terms, provide an ecologically grounded example of nature in good
      condition toward which society can aim. Evidence of the reverse-symptoms of land 
      illness-can provide a checklist for risk analysis and management that helps guide
      people away from harm-causing attitudes and activities and toward beneficial
      outcomes. Leopold's criteria of land health motivated by a land ethic that
      incorporates the whole of nature may be applied at geographic scales ranging from
      local to global as a framework for contemporary risk management.
FAU - Warren, Julianne Lutz
AU  - Warren JL
AD  - Liberal Studies Program, Faculty Arts and Science, Affiliate Faculty Member of
      Environmental Studies, Program, New York University, New York, USA. jw156@nyu.edu
FAU - Kieffer, Susan
AU  - Kieffer S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100202
PL  - United States
TA  - Risk Anal
JT  - Risk analysis : an official publication of the Society for Risk Analysis
JID - 8109978
RN  - 0 (Gases)
RN  - 0 (Soil)
SB  - IM
MH  - Agriculture
MH  - Checklist
MH  - *Disasters
MH  - Gases/*chemistry
MH  - Humans
MH  - Risk Assessment/*methods
MH  - Risk Management
MH  - Social Environment
MH  - *Soil
EDAT- 2010/02/09 06:00
MHDA- 2010/09/11 06:00
CRDT- 2010/02/09 06:00
PHST- 2010/02/09 06:00 [entrez]
PHST- 2010/02/09 06:00 [pubmed]
PHST- 2010/09/11 06:00 [medline]
AID - RISK1348 [pii]
AID - 10.1111/j.1539-6924.2009.01348.x [doi]
PST - ppublish
SO  - Risk Anal. 2010 Feb;30(2):165-74. doi: 10.1111/j.1539-6924.2009.01348.x. Epub
      2010 Feb 2.


PMID- 20136577
OWN - NLM
STAT- MEDLINE
DCOM- 20100616
LR  - 20220330
IS  - 1473-4877 (Electronic)
IS  - 0300-7995 (Linking)
VI  - 26
IP  - 4
DP  - 2010 Apr
TI  - How long does it take for the scientific literature to purge itself of fraudulent
      material?: the Breuning case revisited.
PG  - 843-7
LID - 10.1185/03007991003603804 [doi]
AB  - OBJECTIVE: It has been proposed that the scientific literature purges itself of
      articles known to be fraudulent. To test this, an investigation was carried out
      of post-retraction citations over a 19-year period in the Breuning case. METHODS:
      On 10 March 2008 a cited reference search was conducted (all languages, all
      document types) using the name 'Breuning SE*'. The time limit was 1989-2007 with 
      an option to exclude self-citations. The search included the ISI Web of Science
      Database including the Science Citation Index Expanded, the Social Sciences
      Citations Index and the Arts & Humanities Citation Index. To ascertain the
      citation context, citations of Breuning were classified by two raters as
      affirmative, negative or neutral. FINDINGS: For the period 1989-2000 both
      negative and affirmative citations were found. For the period 2001-2006 only
      affirmative citations (even to retracted articles) were found, some in journals
      with higher impact factors than those citing the case as fraudulent. In spite of 
      the small number of citations of Breuning's articles, it is alarming that the
      affirmative citing of fraudulent research has not completely ceased but continues
      24 years post-retraction (retracted 1982, cited 2006). While the limitations of a
      single case study are conceded, the results challenge the belief of scientific
      literature purging itself of fraudulent material. CONCLUSIONS: Retraction
      databases and widespread availability of computer software to check lists of
      references free of charge in any database or the internet are called for.
      Moreover, if a paper is never formally retracted, software for searching author
      names in the internet for fully investigated and proven scientific misconduct
      might be developed. The ethical guidelines on duplicate publication for purposes 
      of disseminating the information as widely as possible should be reviewed.
FAU - Korpela, K M
AU  - Korpela KM
AD  - Department of Psychology, University of Tampere, Tampere, Finland.
      kalevi.korpela@uta.fi
LA  - eng
PT  - Biography
PT  - Historical Article
PT  - Journal Article
PL  - England
TA  - Curr Med Res Opin
JT  - Current medical research and opinion
JID - 0351014
SB  - IM
MH  - *Bibliometrics
MH  - *Biomedical Research
MH  - *Databases, Bibliographic
MH  - History, 20th Century
MH  - Humans
MH  - *Information Dissemination
MH  - Information Storage and Retrieval
MH  - *Retraction of Publication as Topic
MH  - Scientific Misconduct/*history
PS  - Breuning SE
FPS - Breuning, Stephen E
EDAT- 2010/02/09 06:00
MHDA- 2010/06/17 06:00
CRDT- 2010/02/09 06:00
PHST- 2010/02/09 06:00 [entrez]
PHST- 2010/02/09 06:00 [pubmed]
PHST- 2010/06/17 06:00 [medline]
AID - 10.1185/03007991003603804 [doi]
PST - ppublish
SO  - Curr Med Res Opin. 2010 Apr;26(4):843-7. doi: 10.1185/03007991003603804.


PMID- 20136458
OWN - NLM
STAT- MEDLINE
DCOM- 20100805
LR  - 20181201
IS  - 1557-7600 (Electronic)
IS  - 1096-620X (Linking)
VI  - 13
IP  - 1
DP  - 2010 Feb
TI  - Effects of coenzyme Q10 supplementation on plasma adiponectin, interleukin-6, and
      tumor necrosis factor-alpha levels in men.
PG  - 216-8
LID - 10.1089/jmf.2008.0310 [doi]
AB  - The aim of the study was to determine the effects of coenzyme Q10 supplementation
      on plasma adiponectin, interleukin (IL)-6, and tumor necrosis factor (TNF )-alpha
      levels in sedentary men. Fourteen healthy, nonsmoking, sedentary men participated
      in the study. The protocol was approved by the Ethical Committee of our
      institution. This study was a randomized, double-blind, crossover trial. Blood
      samples were collected from all participants before coenzyme Q10 or placebo
      supplementation. The participants were randomly allocated to two groups. Seven
      participants received oral coenzyme Q10 (100 mg/day) supplementation, and seven
      participants received placebo (glucose) for 8 weeks. At the end of the 8 weeks, a
      second blood sampling was performed. After a 4-week washout period, placebo was
      given to the participants who used coenzyme Q10 the first time, and vice versa,
      and blood sampling was repeated. Plasma was stored at -80 degrees C until the
      time of analysis for adiponectin, IL-6, and TNF-alpha. Both CoQ10 and placebo
      supplementation did not affect plasma adiponectin and TNF-alpha levels. IL-6
      level increased with coenzyme Q10 supplementation, but this increase did not
      differ from that seen with placebo supplementation. Coenzyme Q10 supplementation 
      did not affect plasma adiponectin, IL-6, and TNF-alpha levels in sedentary men.
FAU - Gokbel, Hakki
AU  - Gokbel H
AD  - Department of Physiology, Meram Faculty of Medicine, Selcuk University, Konya,
      Turkey.
FAU - Gergerlioglu, Hasan Serdar
AU  - Gergerlioglu HS
FAU - Okudan, Nilsel
AU  - Okudan N
FAU - Gul, Ibrahim
AU  - Gul I
FAU - Buyukbas, Sadik
AU  - Buyukbas S
FAU - Belviranli, Muaz
AU  - Belviranli M
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - J Med Food
JT  - Journal of medicinal food
JID - 9812512
RN  - 0 (Adiponectin)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Vitamins)
RN  - 1339-63-5 (Ubiquinone)
RN  - EJ27X76M46 (coenzyme Q10)
SB  - IM
MH  - Adiponectin/*blood
MH  - Cross-Over Studies
MH  - *Dietary Supplements
MH  - Double-Blind Method
MH  - Humans
MH  - Interleukin-6/*blood
MH  - Male
MH  - Sedentary Behavior
MH  - Tumor Necrosis Factor-alpha/*blood
MH  - Ubiquinone/*analogs & derivatives/pharmacology
MH  - Vitamins/*pharmacology
MH  - Young Adult
EDAT- 2010/02/09 06:00
MHDA- 2010/08/06 06:00
CRDT- 2010/02/09 06:00
PHST- 2010/02/09 06:00 [entrez]
PHST- 2010/02/09 06:00 [pubmed]
PHST- 2010/08/06 06:00 [medline]
AID - 10.1089/jmf.2008.0310 [doi]
PST - ppublish
SO  - J Med Food. 2010 Feb;13(1):216-8. doi: 10.1089/jmf.2008.0310.


PMID- 20135302
OWN - NLM
STAT- MEDLINE
DCOM- 20101028
LR  - 20211020
IS  - 1433-3023 (Electronic)
IS  - 0937-3462 (Linking)
VI  - 21
IP  - 7
DP  - 2010 Jul
TI  - Uterus conserving prolapse surgery--what is the chance of missing a malignancy?
PG  - 819-21
LID - 10.1007/s00192-010-1101-9 [doi]
AB  - INTRODUCTION AND HYPOTHESIS: Recently, there has been a move towards uterine
      preserving surgery in the management of pelvic organ prolapse. The negative
      implications of such surgery have not been delineated. This study aims to
      identify the risk of finding an unexpected malignancy in these cases. METHODS: A 
      database containing details of vaginal hysterectomies performed over a 10-year
      period was searched. Women who underwent surgery for uterine prolapse were
      included. Women with other indications for surgery and those who presented with
      symptoms relating to endometrial or cervical malignancy were excluded. As this is
      a non-interventional observational study, formal ethical approval was not
      obtained. RESULTS: Out of 517 women who underwent a vaginal hysterectomy for
      prolapse, four cases of endometrial carcinoma were identified giving an incidence
      of 0.8%. CONCLUSIONS: Conserving a prolapsed uterus without further
      investigations runs the risk of missing women with endometrial malignancy.
FAU - Renganathan, Arasee
AU  - Renganathan A
AD  - Medway Maritime Hospital, London, UK.
FAU - Edwards, Robin
AU  - Edwards R
FAU - Duckett, Jonathan R A
AU  - Duckett JR
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20100205
PL  - England
TA  - Int Urogynecol J
JT  - International urogynecology journal
JID - 101567041
SB  - IM
MH  - Aged
MH  - Female
MH  - Humans
MH  - Hysterectomy
MH  - Middle Aged
MH  - Pelvic Organ Prolapse/complications/*surgery
MH  - Uterine Neoplasms/complications/*diagnosis/epidemiology
MH  - Uterus
EDAT- 2010/02/06 06:00
MHDA- 2010/10/29 06:00
CRDT- 2010/02/06 06:00
PHST- 2009/09/21 00:00 [received]
PHST- 2010/01/01 00:00 [accepted]
PHST- 2010/02/06 06:00 [entrez]
PHST- 2010/02/06 06:00 [pubmed]
PHST- 2010/10/29 06:00 [medline]
AID - 10.1007/s00192-010-1101-9 [doi]
PST - ppublish
SO  - Int Urogynecol J. 2010 Jul;21(7):819-21. doi: 10.1007/s00192-010-1101-9. Epub
      2010 Feb 5.


PMID- 20135090
OWN - NLM
STAT- MEDLINE
DCOM- 20100519
LR  - 20211020
IS  - 1432-1238 (Electronic)
IS  - 0342-4642 (Linking)
VI  - 36
IP  - 3
DP  - 2010 Mar
TI  - Recommendations for intensive care unit and hospital preparations for an
      influenza epidemic or mass disaster: summary report of the European Society of
      Intensive Care Medicine's Task Force for intensive care unit triage during an
      influenza epidemic or mass disaster.
PG  - 428-43
LID - 10.1007/s00134-010-1759-y [doi]
AB  - PURPOSE: To provide recommendations and standard operating procedures for
      intensive care units and hospital preparedness for an influenza pandemic.
      METHODS: Based on a literature review and expert opinion, a Delphi process was
      used to define the essential topics. RESULTS: Key recommendations include:
      Hospitals should increase their ICU beds to the maximal extent by expanding ICU
      capacity and expanding ICUs into other areas. Hospitals should have appropriate
      beds and monitors for these expansion areas. Establish a management system with
      control groups at facility, local, regional and/or national levels to exercise
      authority over resources. Establish a system of communication, coordination and
      collaboration between the ICU and key interface departments. A plan to access,
      coordinate and increase labor resources is required with a central inventory of
      all clinical and non-clinical staff. Delegate duties not within the usual scope
      of workers' practice. Ensure that adequate essential medical equipment,
      pharmaceuticals and supplies are available. Protect patients and staff with
      infection control practices and supporting occupational health policies. Maintain
      staff confidence with reassurance plans for legal protection and assistance. Have
      objective, ethical, transparent triage criteria that are applied equitably and
      publically disclosed. ICU triage of patients should be based on the likelihood
      for patients to benefit most or a 'first come, first served' basis. Develop
      protocols for safe performance of high-risk procedures. Train and educate staff. 
      CONCLUSIONS: Mortality, although inevitable during a severe influenza outbreak or
      disaster, can be reduced by adequate preparation.
FAU - Sprung, Charles L
AU  - Sprung CL
AD  - Department of Anesthesiology and Critical Care Medicine, Hadassah Hebrew
      University Medical Center, Jerusalem, Israel. charles.sprung@ekmd.huji.ac.il
FAU - Zimmerman, Janice L
AU  - Zimmerman JL
FAU - Christian, Michael D
AU  - Christian MD
FAU - Joynt, Gavin M
AU  - Joynt GM
FAU - Hick, John L
AU  - Hick JL
FAU - Taylor, Bruce
AU  - Taylor B
FAU - Richards, Guy A
AU  - Richards GA
FAU - Sandrock, Christian
AU  - Sandrock C
FAU - Cohen, Robert
AU  - Cohen R
FAU - Adini, Bruria
AU  - Adini B
CN  - European Society of Intensive Care Medicine Task Force for Intensive Care Unit
      Triage during an Influenza Epidemic or Mass Disaster
LA  - eng
PT  - Guideline
PT  - Journal Article
PT  - Review
DEP - 20100205
PL  - United States
TA  - Intensive Care Med
JT  - Intensive care medicine
JID - 7704851
SB  - IM
MH  - *Advisory Committees
MH  - Clinical Protocols
MH  - Cooperative Behavior
MH  - *Disease Outbreaks
MH  - Equipment and Supplies, Hospital
MH  - Europe/epidemiology
MH  - *Health Planning Guidelines
MH  - Hospital Bed Capacity
MH  - Humans
MH  - Influenza, Human/*epidemiology
MH  - Inservice Training
MH  - Intensive Care Units/*organization & administration
MH  - *Mass Casualty Incidents
MH  - Safety Management
MH  - Surge Capacity/organization & administration
MH  - Triage/*organization & administration
MH  - Workforce
RF  - 68
PMC - PMC7079971
EDAT- 2010/02/06 06:00
MHDA- 2010/05/21 06:00
CRDT- 2010/02/06 06:00
PHST- 2009/11/04 00:00 [received]
PHST- 2010/01/12 00:00 [accepted]
PHST- 2010/02/06 06:00 [entrez]
PHST- 2010/02/06 06:00 [pubmed]
PHST- 2010/05/21 06:00 [medline]
AID - 10.1007/s00134-010-1759-y [doi]
PST - ppublish
SO  - Intensive Care Med. 2010 Mar;36(3):428-43. doi: 10.1007/s00134-010-1759-y. Epub
      2010 Feb 5.


PMID- 20135083
OWN - NLM
STAT- MEDLINE
DCOM- 20100729
LR  - 20170410
IS  - 2511-705X (Electronic)
IS  - 0026-1270 (Linking)
VI  - 49
IP  - 2
DP  - 2010
TI  - Architectural approach to eHealth for enabling paradigm changes in health.
PG  - 123-34
LID - 10.3414/ME9308 [doi]
AB  - OBJECTIVES: For improving safety and quality of care as well as efficiency of
      health delivery under the well-known burdens, health services become specialized,
      distributed, and therefore collaborative, thereby changing the health service
      paradigm from organization-centered over process-controlled to personal health
      (pHealth). METHODS: Personalized eHealth services provided independent of time
      and location have to be based on advanced technical paradigms of mobile,
      pervasive and autonomous computing, enabling ubiquitous health services.
      Personalized eHealth systems require a multidisciplinary approach including
      medicine, informatics, biomedical engineering, bioinformatics and the omics
      disciplines but also legal and regulatory affairs, administration, security,
      privacy and ethics, etc. Interoperability between different components of the
      intended system must be provided through an architecture-centric, model-driven,
      formalized process. RESULTS: In order to analyze, design, specify, implement and 
      maintain such an interactive environment impacted by so many different domains, a
      formal and unified methodology for system analysis and design has been developed 
      and deployed, based on an overall architectural framework. The paper introduces
      the underlying paradigms, requirements, architectural reference models, modeling 
      and formalization principles as well as development processes for comprehensive
      service-oriented personalized eHealth interoperability chains, thereby exploiting
      all interoperability levels up to service interoperability. A special focus is
      put on ontologies and knowledge representation in the context of eHealth and
      pHealth solutions. Furthermore, EHR solutions, security requirements, existing
      and emerging standards, and educational challenges for realizing personalized
      pHealth are briefly discussed. CONCLUSION: For personal health, bridging between 
      disciplines including ontology coordination is the crucial demand. All aspects of
      the design and development process have to be considered from an architectural
      viewpoint.
FAU - Blobel, B
AU  - Blobel B
AD  - eHealth Competence Center, University Hospital Regensburg,
      Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany.
      bernd.blobel@klinik.uni-regensburg.de
LA  - eng
PT  - Journal Article
DEP - 20100205
PL  - Germany
TA  - Methods Inf Med
JT  - Methods of information in medicine
JID - 0210453
SB  - IM
MH  - *Computer Systems
MH  - Efficiency, Organizational
MH  - Medical Informatics/*organization & administration
MH  - Quality of Health Care
MH  - Semantics
MH  - Specialization
MH  - *Systems Integration
EDAT- 2010/02/06 06:00
MHDA- 2010/07/30 06:00
CRDT- 2010/02/06 06:00
PHST- 2010/02/06 06:00 [entrez]
PHST- 2010/02/06 06:00 [pubmed]
PHST- 2010/07/30 06:00 [medline]
AID - 9308 [pii]
AID - 10.3414/ME9308 [doi]
PST - ppublish
SO  - Methods Inf Med. 2010;49(2):123-34. doi: 10.3414/ME9308. Epub 2010 Feb 5.


PMID- 20134110
OWN - NLM
STAT- MEDLINE
DCOM- 20100401
LR  - 20190923
IS  - 0021-5082 (Print)
IS  - 0021-5082 (Linking)
VI  - 65
IP  - 1
DP  - 2010 Jan
TI  - [Attitudes towards the code of conduct for scientists among council members of
      the Japanese Society for Hygiene].
PG  - 60-74
AB  - OBJECTIVES: The aim of this study was to clarify the attitudes towards the code
      of conduct for scientists among council members of the Japanese Society for
      Hygiene (JSH). We also aimed to collect information to be used as baseline data
      for future studies. METHODS: From November to December 2007, 439 Council members 
      of the Japanese Society for Hygiene completed a self-administered questionnaire. 
      RESULTS: The valid response rate was 43.7% (n=192/439). The mean ages of the
      subjects were 56.2 years for males (n=171), and 53.0 years for females (n=19).
      Many council members were unfamiliar with the "Code of Conduct for Scientists"
      established by the Science Council of Japan, suggesting that most of the regular 
      members were also unfamiliar with these guidelines. However, the high level of
      interest in the "Code of Conduct for Scientists" established by the Science
      Council of Japan indicated a positive attitude towards learning about research
      ethics. Moreover, one-half of the subjects responded that JSH should establish a 
      code of conduct for scientists. Below are some of the reasons for requiring JSH
      to establish a code of conduct: 1. Private information is prevalent in the field 
      of hygiene. 2. The overall stance as an academic society would be established and
      would encourage individuality in academic societies. 3. Members have various
      backgrounds within the field of hygiene, and they should have a code of conduct
      different from that of their institution of affiliation. CONCLUSION: We clarified
      attitudes towards the Code of Conduct for Scientists among council members of the
      Japanese Society for Hygiene.
FAU - Ikeda, Wakaha
AU  - Ikeda W
AD  - Department of Epidemiology and Environmental Health, Juntendo University School
      of Medicine, Tokyo, Japan. wakaha@juntendo.ac.jp
FAU - Inaba, Yutaka
AU  - Inaba Y
FAU - Yoshida, Katsumi
AU  - Yoshida K
FAU - Takeshita, Tatsuya
AU  - Takeshita T
FAU - Ogoshi, Kumiko
AU  - Ogoshi K
FAU - Okamoto, Kazushi
AU  - Okamoto K
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Nihon Eiseigaku Zasshi
JT  - Nihon eiseigaku zasshi. Japanese journal of hygiene
JID - 0417457
SB  - IM
MH  - Adult
MH  - Aged
MH  - Allied Health Personnel/*psychology
MH  - *Attitude
MH  - *Codes of Ethics
MH  - Female
MH  - Humans
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Societies, Scientific/*organization & administration
MH  - Surveys and Questionnaires
EDAT- 2010/02/06 06:00
MHDA- 2010/04/02 06:00
CRDT- 2010/02/06 06:00
PHST- 2010/02/06 06:00 [entrez]
PHST- 2010/02/06 06:00 [pubmed]
PHST- 2010/04/02 06:00 [medline]
AID - JST.JSTAGE/jjh/65.60 [pii]
AID - 10.1265/jjh.65.60 [doi]
PST - ppublish
SO  - Nihon Eiseigaku Zasshi. 2010 Jan;65(1):60-74. doi: 10.1265/jjh.65.60.


PMID- 20134087
OWN - NLM
STAT- MEDLINE
DCOM- 20100429
LR  - 20100624
IS  - 1875-8622 (Electronic)
IS  - 1386-0291 (Linking)
VI  - 44
IP  - 1
DP  - 2010
TI  - Ethical guidelines for publication in Clinical Hemorheology and Microcirculation.
PG  - 1-2
LID - 10.3233/CH-2010-1256A [doi]
LA  - eng
PT  - Editorial
PL  - Netherlands
TA  - Clin Hemorheol Microcirc
JT  - Clinical hemorheology and microcirculation
JID - 9709206
SB  - IM
MH  - Guidelines as Topic
MH  - Hemorheology
MH  - Microcirculation
MH  - Publications/*ethics
MH  - Publishing/*ethics
MH  - Scientific Misconduct/legislation & jurisprudence
EDAT- 2010/02/06 06:00
MHDA- 2010/04/30 06:00
CRDT- 2010/02/06 06:00
PHST- 2010/02/06 06:00 [entrez]
PHST- 2010/02/06 06:00 [pubmed]
PHST- 2010/04/30 06:00 [medline]
AID - 2U772NHQ50465558 [pii]
AID - 10.3233/CH-2010-1256A [doi]
PST - ppublish
SO  - Clin Hemorheol Microcirc. 2010;44(1):1-2. doi: 10.3233/CH-2010-1256A.


PMID- 20133558
OWN - NLM
STAT- MEDLINE
DCOM- 20100224
LR  - 20121115
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Linking)
VI  - 327
IP  - 5966
DP  - 2010 Feb 5
TI  - Ethics. Gene doping and sport.
PG  - 647-8
LID - 10.1126/science.1177801 [doi]
FAU - Friedmann, Theodore
AU  - Friedmann T
AD  - University of California at San Diego, La Jolla, CA 92093, USA.
FAU - Rabin, Olivier
AU  - Rabin O
FAU - Frankel, Mark S
AU  - Frankel MS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
SB  - IM
MH  - Animals
MH  - Athletic Performance/*ethics
MH  - *Doping in Sports
MH  - Genetic Enhancement/*ethics
MH  - Genetic Therapy/ethics
MH  - Humans
MH  - Sports/*ethics
EDAT- 2010/02/06 06:00
MHDA- 2010/02/25 06:00
CRDT- 2010/02/06 06:00
PHST- 2010/02/06 06:00 [entrez]
PHST- 2010/02/06 06:00 [pubmed]
PHST- 2010/02/25 06:00 [medline]
AID - 327/5966/647 [pii]
AID - 10.1126/science.1177801 [doi]
PST - ppublish
SO  - Science. 2010 Feb 5;327(5966):647-8. doi: 10.1126/science.1177801.


PMID- 20133506
OWN - NLM
STAT- MEDLINE
DCOM- 20100511
LR  - 20100205
IS  - 1049-7323 (Print)
IS  - 1049-7323 (Linking)
VI  - 20
IP  - 3
DP  - 2010 Mar
TI  - Families' and professional caregivers' views of using advanced technology to
      track people with dementia.
PG  - 409-19
LID - 10.1177/1049732309359171 [doi]
AB  - in this study we examined the ethical aspects of the use of the Global
      Positioning Systems (GPS) to track people with dementia. The findings are based
      on qualitative data gathered from focus groups of family and professional
      caregivers. The most important theme was the need to balance patients' need for
      safety with the need to preserve their autonomy and privacy. The main potential
      benefit of the use of GPS was related to the peace of mind of the caregivers
      themselves. The findings also suggest that caregivers' views change according to 
      the locus of responsibility of the caregivers for the safety of people with
      dementia. The caregivers give preference to patients' safety more than autonomy
      when they are responsible for the patients. When the patients are under the
      responsibility of other caregivers, they give preference to patients' autonomy
      more than their safety. Overall, the variety and the depth of the views of
      different stakeholders toward the use of electronic tracking for people with
      dementia presented in this article provide a meaningful contribution to the
      ethical debate on this topic.
FAU - Landau, Ruth
AU  - Landau R
AD  - The Hebrew University of Jerusalem, Jerusalem, Israel. mslanda@mscc.huji.ac.il
FAU - Auslander, Gail K
AU  - Auslander GK
FAU - Werner, Shirli
AU  - Werner S
FAU - Shoval, Noam
AU  - Shoval N
FAU - Heinik, Jeremia
AU  - Heinik J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Qual Health Res
JT  - Qualitative health research
JID - 9202144
MH  - Aged
MH  - Caregivers/*psychology
MH  - Dementia/*therapy
MH  - Family/psychology
MH  - Female
MH  - Geographic Information Systems/*ethics/instrumentation
MH  - Health Personnel/psychology
MH  - Humans
MH  - Israel
MH  - Male
MH  - Monitoring, Ambulatory/*ethics/instrumentation/psychology
MH  - Personal Autonomy
MH  - Privacy
MH  - Qualitative Research
MH  - Safety
MH  - *Wandering Behavior
EDAT- 2010/02/06 06:00
MHDA- 2010/05/12 06:00
CRDT- 2010/02/06 06:00
PHST- 2010/02/06 06:00 [entrez]
PHST- 2010/02/06 06:00 [pubmed]
PHST- 2010/05/12 06:00 [medline]
AID - 20/3/409 [pii]
AID - 10.1177/1049732309359171 [doi]
PST - ppublish
SO  - Qual Health Res. 2010 Mar;20(3):409-19. doi: 10.1177/1049732309359171.


PMID- 20133408
OWN - NLM
STAT- MEDLINE
DCOM- 20100520
LR  - 20181201
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 2
DP  - 2010 Feb
TI  - The use of placebo in a trial of rectal artesunate as initial treatment for
      severe malaria patients en route to referral clinics: ethical issues.
PG  - 116-20
LID - 10.1136/jme.2009.030874 [doi]
AB  - Placebo-controlled trials are controversial when individuals might be denied
      existing beneficial medical interventions. In the case of malaria, most patients 
      die in rural villages without healthcare facilities. An artesunate suppository
      that can be given by minimally skilled persons might be of value when patients
      suddenly become too ill for oral treatment but are several hours from a facility 
      that can give injectable treatment for severe disease. In such situations, by
      default, no treatment is (or can be) given until the patient reaches a facility, 
      making the placebo control design clinically relevant; alternative bioequivalence
      designs at the facility would misrepresent reality and risk incorrect
      conclusions. We describe the ethical issues underpinning a placebo-controlled
      trial in severe malaria. To protect patients and minimise risk, all patients were
      referred immediately to hospital so that each had a higher chance of prompt
      treatment through participation. There was no difference between artesunate and
      placebo in patients who reached clinic rapidly; among those who could not, a
      single artesunate suppository significantly reduced death or permanent
      disability, a finding of direct and indirect benefit to patients in participating
      villages and elsewhere.
FAU - Kitua, Andrew
AU  - Kitua A
AD  - UNICEF/UNDP/World Bank/WHO Special Programme for Research & Training in Tropical 
      Diseases, World Health Organization, Geneva 27, Geneva, Switzerland.
FAU - Folb, Peter
AU  - Folb P
FAU - Warsame, Marian
AU  - Warsame M
FAU - Binka, Fred
AU  - Binka F
FAU - Faiz, Abul
AU  - Faiz A
FAU - Ribeiro, Isabela
AU  - Ribeiro I
FAU - Peto, Tom
AU  - Peto T
FAU - Gyapong, John
AU  - Gyapong J
FAU - Yunus, Emran Bin
AU  - Yunus EB
FAU - Rahman, Ridwan
AU  - Rahman R
FAU - Baiden, Frank
AU  - Baiden F
FAU - Clerk, Christine
AU  - Clerk C
FAU - Mrango, Zakayo
AU  - Mrango Z
FAU - Makasi, Charles
AU  - Makasi C
FAU - Kimbute, Omari
AU  - Kimbute O
FAU - Hossain, Amir
AU  - Hossain A
FAU - Samad, Rasheda
AU  - Samad R
FAU - Gomes, Melba
AU  - Gomes M
LA  - eng
GR  - Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
RN  - 0 (Antimalarials)
RN  - 0 (Artemisinins)
RN  - 0 (Placebos)
RN  - 0 (Suppositories)
RN  - 60W3249T9M (Artesunate)
SB  - IM
MH  - Administration, Rectal
MH  - Antimalarials/*administration & dosage
MH  - Artemisinins/*administration & dosage
MH  - Artesunate
MH  - Health Services Accessibility/*ethics
MH  - Humans
MH  - Malaria/*drug therapy
MH  - Medication Adherence
MH  - Placebos/*administration & dosage
MH  - Randomized Controlled Trials as Topic/*ethics
MH  - Referral and Consultation
MH  - Rural Health
MH  - Suppositories
EDAT- 2010/02/06 06:00
MHDA- 2010/05/21 06:00
CRDT- 2010/02/06 06:00
PHST- 2010/02/06 06:00 [entrez]
PHST- 2010/02/06 06:00 [pubmed]
PHST- 2010/05/21 06:00 [medline]
AID - jme.2009.030874 [pii]
AID - 10.1136/jme.2009.030874 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Feb;36(2):116-20. doi: 10.1136/jme.2009.030874.


PMID- 20133407
OWN - NLM
STAT- MEDLINE
DCOM- 20100520
LR  - 20100205
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 2
DP  - 2010 Feb
TI  - Hidden risks associated with clinical trials in developing countries.
PG  - 111-5
LID - 10.1136/jme.2009.031708 [doi]
AB  - The academic literature in research ethics has been marked in the past decade by 
      a much broader focus on the need for the protection of developing communities
      subjected to international clinical trials. Because of the proximity of the
      revision of the Declaration of Helsinki, completed in October 2008, most papers
      have addressed the issue of a double standard of care following the use of
      placebo. However, other no less important issues, such as interactions between
      the lifestyles structures of low-income communities and the efficiency of
      risk-minimising procedures also deserve attention. The purpose of this paper is
      to discuss forms of uncertainty involved in clinical trials in poor and
      low-income countries that are not addressed by conventional methods of risk
      assessment. Furthermore, the increase in size of risks that are identified by
      conventional assessment methods will be addressed. Besides, the difficulty in
      properly applying risk-minimising procedures will be discussed. Finally, this
      paper proposes the involvement of research ethics committees in the risk
      evaluation process and the establishment of national ethics evaluation systems.
FAU - Lorenzo, Claudio
AU  - Lorenzo C
AD  - Department of Public Health, University of Brasilia, Brazil.
      claudiolorenzo@unb.br
FAU - Garrafa, Volnei
AU  - Garrafa V
FAU - Solbakk, Jan Helge
AU  - Solbakk JH
FAU - Vidal, Susana
AU  - Vidal S
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Clinical Trials as Topic/*ethics
MH  - Developing Countries
MH  - Ethics Committees, Research/*ethics
MH  - Humans
MH  - Patient Selection/*ethics
MH  - Risk Assessment
EDAT- 2010/02/06 06:00
MHDA- 2010/05/21 06:00
CRDT- 2010/02/06 06:00
PHST- 2010/02/06 06:00 [entrez]
PHST- 2010/02/06 06:00 [pubmed]
PHST- 2010/05/21 06:00 [medline]
AID - jme.2009.031708 [pii]
AID - 10.1136/jme.2009.031708 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Feb;36(2):111-5. doi: 10.1136/jme.2009.031708.


PMID- 20133399
OWN - NLM
STAT- MEDLINE
DCOM- 20100520
LR  - 20100205
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 2
DP  - 2010 Feb
TI  - Apotemnophilia: ethical considerations of amputating a healthy limb.
PG  - 75-8
LID - 10.1136/jme.2009.031070 [doi]
AB  - Apotemnophilia is a condition that causes those who have it to not feel "correct"
      in their own bodies. As a result, an intense obsession develops with removing the
      limb; this obsession hinders tremendously the patients' social behaviour and
      societal integration. These patients, in some respects resembling transgendered
      individuals, feel that the body part (limb) in question is simply "not a part of 
      themselves", causing them to feel uncomfortable in their own bodies. Whether
      amputations should be performed on apotemnophiles or not is a question that poses
      a significant medical ethical dilemma. It is argued that observing an
      apotemnophile's request for amputation is the ethical action. The major arguments
      opposing such amputations and supporting such amputations are examined and
      critically analysed with regard to ethical principles-namely, patient autonomy,
      beneficence, non-maleficence and justice with regard to every person's "right to 
      happiness". Finally, a discourse on how the accepted notion of harm does not
      apply to apotemnophilia is developed to justify the position that amputation is
      indeed medically the ethical choice.
FAU - Dua, A
AU  - Dua A
AD  - University of Aberdeen Medical School, Mealmarket Exchange, Mealmarket Street,
      Aberdeen AB24-5SW, Scotland. Anahita46@yahoo.com
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Amputation/*ethics/psychology
MH  - Beneficence
MH  - Body Image
MH  - Extremities/surgery
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Moral Obligations
MH  - Obsessive-Compulsive Disorder/*psychology
MH  - Patient Rights/*ethics
MH  - Physician-Patient Relations/*ethics
MH  - Unnecessary Procedures/ethics/psychology
EDAT- 2010/02/06 06:00
MHDA- 2010/05/21 06:00
CRDT- 2010/02/06 06:00
PHST- 2010/02/06 06:00 [entrez]
PHST- 2010/02/06 06:00 [pubmed]
PHST- 2010/05/21 06:00 [medline]
AID - 36/2/75 [pii]
AID - 10.1136/jme.2009.031070 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Feb;36(2):75-8. doi: 10.1136/jme.2009.031070.


PMID- 20133398
OWN - NLM
STAT- MEDLINE
DCOM- 20100520
LR  - 20100205
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 2
DP  - 2010 Feb
TI  - Skeletal age determination in adolescents involved in judicial procedures: from
      evidence-based principles to medical practice.
PG  - 71-4
LID - 10.1136/jme.2009.031948 [doi]
AB  - BACKGROUND: The ideal basis of age estimation is considered to be a combination
      of clinical, skeletal and dental examinations. It is not easy to determine how
      forensic physicians take account of evidence-based data obtained from medical
      journals in their medical decision-making. The question of what is an ethically
      acceptable probability that adolescents are incorrectly considered to be over 18 
      has not been answered. METHODS: In a retrospective study over 1 year (2007), 498 
      files (for 141 female subjects and 357 male subjects) regarding age assessment
      requested by the public prosecutor's office for purposes of criminal or asylum
      proceedings were reviewed. Chronological age was estimated from a combination of 
      physical examination, radiographic examination of the left hand and determination
      of dental status. RESULTS: Estimates of chronological age in 498 subjects
      claiming to be 9-14 years old were incompatible with the alleged age in 356 (71%)
      when made by the forensic physician but in only 17 (3%) when based on data from
      published studies on age estimation in adolescents. CONCLUSIONS: The present
      study suggests that in most cases the forensic physician ignores the adolescent's
      word. Medical mission and ethics imply a need to listen to the claims of persons 
      in custody, whatever the risk of false claims. This situation should prompt
      forensic physicians to keep up with published data on estimating the age of
      adolescents.
FAU - Pruvost, Marie-Odile
AU  - Pruvost MO
AD  - Unit of Forensic Medicine, Hopital Jean-Verdier (AP-HP), 93143 Bondy, France.
FAU - Boraud, Cyril
AU  - Boraud C
FAU - Chariot, Patrick
AU  - Chariot P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Determination by Skeleton/*methods
MH  - Child
MH  - *Criminals
MH  - Decision Making
MH  - Evidence-Based Medicine
MH  - Female
MH  - *Forensic Medicine
MH  - Humans
MH  - Male
MH  - Retrospective Studies
MH  - Young Adult
EDAT- 2010/02/06 06:00
MHDA- 2010/05/21 06:00
CRDT- 2010/02/06 06:00
PHST- 2010/02/06 06:00 [entrez]
PHST- 2010/02/06 06:00 [pubmed]
PHST- 2010/05/21 06:00 [medline]
AID - jme.2009.031948 [pii]
AID - 10.1136/jme.2009.031948 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Feb;36(2):71-4. doi: 10.1136/jme.2009.031948.


PMID- 20133397
OWN - NLM
STAT- MEDLINE
DCOM- 20100520
LR  - 20100205
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 2
DP  - 2010 Feb
TI  - Are physicians obligated always to act in the patient's best interests?
PG  - 66-70
LID - 10.1136/jme.2009.033001 [doi]
AB  - The principle that physicians should always act in the best interests of the
      present patient is widely endorsed. At the same time, and often within the same
      document, it is recognised that there are appropriate exceptions to this
      principle. Unfortunately, little, if any, guidance is provided regarding which
      exceptions are appropriate and how they should be handled. These circumstances
      might be tenable if the appropriate exceptions were rare. Yet, evaluation of the 
      literature reveals that there are numerous exceptions, several of which pervade
      clinical medicine. This situation leaves physicians without adequate guidance on 
      when to allow exceptions and how to address them, increasing the chances for
      unfairness in practice. The present article considers the range of exceptions,
      illustrates how the lack of guidance poses ethical concern and describes an
      alternative account of physician obligations to address this concern.
FAU - Wendler, David
AU  - Wendler D
AD  - Department of Bioethics, NIH Clinical Center, Bethesda, MD 20892-1156, USA.
      dwendler@nih.gov
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Moral Obligations
MH  - *Physician's Role
MH  - Physician-Patient Relations/*ethics
MH  - Professional Autonomy
EDAT- 2010/02/06 06:00
MHDA- 2010/05/21 06:00
CRDT- 2010/02/06 06:00
PHST- 2010/02/06 06:00 [entrez]
PHST- 2010/02/06 06:00 [pubmed]
PHST- 2010/05/21 06:00 [medline]
AID - jme.2009.033001 [pii]
AID - 10.1136/jme.2009.033001 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Feb;36(2):66-70. doi: 10.1136/jme.2009.033001.


PMID- 20132653
OWN - NLM
STAT- MEDLINE
DCOM- 20100518
LR  - 20100205
IS  - 1476-8305 (Electronic)
IS  - 1028-415X (Linking)
VI  - 13
IP  - 1
DP  - 2010 Feb
TI  - Undernutrition during either the pre- or immediate post-weaning period does not
      affect longevity in Quackenbush mice.
PG  - 33-42
LID - 10.1179/147683010X12611460763724 [doi]
AB  - Diet restriction of rodents during a lengthy period of adult life, can lead to a 
      marked increase in their life-span. However, undernutrition during gestation
      and/or the suckling period is, paradoxically, known to cause long-lasting
      'deleterious' deficits in body and brain structure. It remains uncertain whether 
      or not such undernourished rodents also have an altered life-span. We have now
      investigated whether a short period of undernutrition of mice either before or
      immediately after the weaning period could modulate their life-span. Female
      out-bred Quackenbush mice were undernourished for 40 days by standardised
      procedures either from conception until weaning or from weaning (day 19) till
      60-days-of-age and compared to control mice that had been well-nourished
      throughout their lives. During the course of their life-span, some mice in each
      group became seriously ill and, because of ethical considerations, were required 
      to be killed before their 'natural' death. The median age of mice at which they
      were required to be euthanized due to illness was significantly younger in the
      well-fed control group compared to the two previously undernourished groups. Of
      those mice that died of natural causes, it was found that about 90% died between 
      about 300-700 (average, 552-570; median, 556-595) days-of-age irrespective of
      group. Any differences between groups were not statistically significant. There
      were no significant differences between groups in the numbers of mice that
      survived beyond the 90th percentile of maximum life-span. Our results provided no
      evidence that a short period of undernutrition of Quackenbush mice either before 
      or immediately after weaning has significant effects on their life-span. However,
      there was some evidence that, if it occurred, serious illness happened at a
      younger age in the well-nourished mice than those in the two diet-restricted
      groups.
FAU - Partadiredja, G
AU  - Partadiredja G
AD  - Department of Physiology, Faculty of Medicine, Gadjah Mada University,
      Yogyakarta, Indonesia.
FAU - Bedi, K S
AU  - Bedi KS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Nutr Neurosci
JT  - Nutritional neuroscience
JID - 100892202
SB  - IM
MH  - Age of Onset
MH  - *Animal Nutritional Physiological Phenomena
MH  - Animals
MH  - Animals, Outbred Strains
MH  - Animals, Suckling
MH  - Body Weight
MH  - Female
MH  - Longevity/*physiology
MH  - Malnutrition/*physiopathology
MH  - *Maternal Nutritional Physiological Phenomena
MH  - Mice
MH  - Pregnancy
MH  - Survival Analysis
MH  - Weaning
EDAT- 2010/02/06 06:00
MHDA- 2010/05/19 06:00
CRDT- 2010/02/06 06:00
PHST- 2010/02/06 06:00 [entrez]
PHST- 2010/02/06 06:00 [pubmed]
PHST- 2010/05/19 06:00 [medline]
AID - 10.1179/147683010X12611460763724 [doi]
PST - ppublish
SO  - Nutr Neurosci. 2010 Feb;13(1):33-42. doi: 10.1179/147683010X12611460763724.


PMID- 20132562
OWN - NLM
STAT- MEDLINE
DCOM- 20100225
LR  - 20100504
IS  - 1876-8784 (Electronic)
IS  - 0028-2162 (Linking)
VI  - 154
DP  - 2010
TI  - [Experimental treatment or medical research?].
PG  - A1197
AB  - If in the Netherlands a doctor offers experimental treatment to patients purely
      because it is in their patients' best interest, thus without serving any
      scientific goal, this does not fall under the scope of the Dutch Medical Research
      involving Human Subjects Act (WMO), but under specifications on the medical
      treatment agreement (WGBO) laid down in the civil code. If the doctor deviates
      from professional standards and the current protocols and guidelines, he or she
      must be able to account for that. The WMO applies as soon as doctors offer
      experimental treatments within the context of a research protocol, or perform
      research interventions such as randomization or the removal of extra tissue. Then
      specific provisions regarding medical ethical protocol review and written
      informed consent should be met.
FAU - Ploem, M C Corette
AU  - Ploem MC
AD  - Academisch Medisch Centrum, Afd. Sociale Geneeskunde, Amsterdam, The Netherlands.
      c.ploem@amc.uva.nl
FAU - Terwiel, Jim
AU  - Terwiel J
LA  - dut
PT  - English Abstract
PT  - Journal Article
TT  - Experimentele behandeling of medisch-wetenschappelijk onderzoek?
PL  - Netherlands
TA  - Ned Tijdschr Geneeskd
JT  - Nederlands tijdschrift voor geneeskunde
JID - 0400770
SB  - IM
MH  - Biomedical Research/*ethics/*legislation & jurisprudence
MH  - Clinical Trials as Topic
MH  - *Ethics, Medical
MH  - *Ethics, Research
MH  - Humans
MH  - *Therapies, Investigational/ethics
EDAT- 2010/02/06 06:00
MHDA- 2010/02/26 06:00
CRDT- 2010/02/06 06:00
PHST- 2010/02/06 06:00 [entrez]
PHST- 2010/02/06 06:00 [pubmed]
PHST- 2010/02/26 06:00 [medline]
PST - ppublish
SO  - Ned Tijdschr Geneeskd. 2010;154:A1197.


PMID- 20132194
OWN - NLM
STAT- MEDLINE
DCOM- 20120209
LR  - 20111012
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 25
IP  - 9
DP  - 2011 Nov
TI  - Parental love pills: some ethical considerations.
PG  - 489-94
LID - 10.1111/j.1467-8519.2009.01796.x [doi]
AB  - It may soon be possible to develop pills that allow parents to induce in
      themselves more loving behaviour, attitudes and emotions towards their children. 
      In this paper, I consider whether pharmacologically induced parental love can
      satisfy reasonable conditions of authenticity; why anyone would be interested in 
      taking such parental love pills at all, and whether inducing parental love
      pharmacologically promotes narcissism or results in self-instrumentalization. I
      also examine how the availability of such pills may affect the duty to love a
      child.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Liao, S Matthew
AU  - Liao SM
AD  - Oxford University, UK. matthew.liao@philosophy.ox.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20100203
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Animals
MH  - *Bioethical Issues
MH  - Child
MH  - Drug Therapy
MH  - Humans
MH  - *Love
MH  - Object Attachment
MH  - *Parent-Child Relations
EDAT- 2010/02/06 06:00
MHDA- 2012/02/10 06:00
CRDT- 2010/02/06 06:00
PHST- 2010/02/06 06:00 [entrez]
PHST- 2010/02/06 06:00 [pubmed]
PHST- 2012/02/10 06:00 [medline]
AID - BIOT1796 [pii]
AID - 10.1111/j.1467-8519.2009.01796.x [doi]
PST - ppublish
SO  - Bioethics. 2011 Nov;25(9):489-94. doi: 10.1111/j.1467-8519.2009.01796.x. Epub
      2010 Feb 3.


PMID- 20132193
OWN - NLM
STAT- MEDLINE
DCOM- 20111019
LR  - 20110608
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 25
IP  - 6
DP  - 2011 Jul
TI  - Triangular reflective equilibrium: a conscience-based method for bioethical
      deliberation.
PG  - 304-19
LID - 10.1111/j.1467-8519.2009.01797.x [doi]
AB  - Following a discussion of some historical roots of conscience, we offer a
      systematized version of reflective equilibrium. Aiming at a comprehensive
      methodology for bioethical deliberation, we develop an expanded variant of
      reflective equilibrium, which we call 'triangular reflective equilibrium' and
      which incorporates insights from hermeneutics, critical theory and narrative
      ethics. We focus on a few distinctions, mainly between methods of justification
      in ethics and the social practice of bioethical deliberation, between coherence
      in ethical reasoning, personal integrity and consensus formation, and between
      political and moral deliberation. The ideal of deliberation is explicated as a
      sharing of conscience within a special commitment to sincerity and openness to
      persuasion. Personal growth in wisdom is an indirect by-product of the continuous
      practice of moral deliberation. This is explicated in the light of Sternberg's
      balance theory of wisdom and in the context of medicine as a profession embodying
      altruistic responsibilities of care in democratic and pluralistic societies.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Barilan, Y Michael
AU  - Barilan YM
AD  - Tel Aviv University Paediatric Department, Tel Aviv 69978, Israel.
      YMBarilan@Gmail.com
FAU - Brusa, Margherita
AU  - Brusa M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100203
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - *Bioethical Issues
MH  - *Conscience
MH  - *Ethical Analysis
MH  - Humans
MH  - Morals
MH  - Philosophy
EDAT- 2010/02/06 06:00
MHDA- 2011/10/20 06:00
CRDT- 2010/02/06 06:00
PHST- 2010/02/06 06:00 [entrez]
PHST- 2010/02/06 06:00 [pubmed]
PHST- 2011/10/20 06:00 [medline]
AID - BIOT1797 [pii]
AID - 10.1111/j.1467-8519.2009.01797.x [doi]
PST - ppublish
SO  - Bioethics. 2011 Jul;25(6):304-19. doi: 10.1111/j.1467-8519.2009.01797.x. Epub
      2010 Feb 3.


PMID- 20132166
OWN - NLM
STAT- MEDLINE
DCOM- 20100805
LR  - 20210423
IS  - 1600-6143 (Electronic)
IS  - 1600-6135 (Linking)
VI  - 10
IP  - 4
DP  - 2010 Apr
TI  - Good ethics requires good science: why transplant programs should not disclose
      misattributed parentage.
PG  - 742-746
LID - 10.1111/j.1600-6143.2009.03011.x [doi]
AB  - In 1996, I argued that the recommendation by the Institute of Medicine (IOM) to
      inform women when tests reveal misattributed paternity and not to disclose this
      information to the women's partners was morally wrong. I argued in favor of
      disclosure to both parties. It is a position that I still hold. But claims of
      misattributed paternity are not 'incidental findings' as it was called in the old
      genetics literature, but a rather serious indictment of biological infidelity. In
      this paper I argue that the tests used by transplant programs for living
      donor-recipient compatibility are inadequate to accurately determine
      misattributed paternity. Further I argue that it is not the responsibility of the
      transplant community to undertake such serious forensic evaluations. Genetic
      inconsistencies in ABO and HLA inheritance should be reported as variations.
      Families who want further clarification should be referred to a genetic
      professional.
FAU - Ross, L F
AU  - Ross LF
AD  - Department of Pediatrics and the MacLean Center for Clinical Medical Ethics,
      University of Chicago, Chicago, IL.
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100203
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
RN  - 0 (ABO Blood-Group System)
RN  - 0 (HLA Antigens)
SB  - IM
CIN - Am J Transplant. 2011 Jan;11(1):179; author reply 180-1. PMID: 21199361
MH  - ABO Blood-Group System/genetics
MH  - Alleles
MH  - Chimera
MH  - *Disclosure
MH  - *Ethics, Medical
MH  - Female
MH  - HLA Antigens/genetics
MH  - *Health Care Rationing
MH  - Humans
MH  - Mosaicism
MH  - *Paternity
MH  - *Transplantation
EDAT- 2010/02/06 06:00
MHDA- 2010/08/06 06:00
CRDT- 2010/02/06 06:00
PHST- 2010/02/06 06:00 [entrez]
PHST- 2010/02/06 06:00 [pubmed]
PHST- 2010/08/06 06:00 [medline]
AID - 10.1111/j.1600-6143.2009.03011.x [doi]
PST - ppublish
SO  - Am J Transplant. 2010 Apr;10(4):742-746. doi: 10.1111/j.1600-6143.2009.03011.x.
      Epub 2010 Feb 3.


PMID- 20131970
OWN - NLM
STAT- MEDLINE
DCOM- 20110124
LR  - 20191210
IS  - 1557-8534 (Electronic)
IS  - 1547-3287 (Linking)
VI  - 19
IP  - 9
DP  - 2010 Sep
TI  - Teratogenic potential in cultures optimized for oligodendrocyte development from 
      mouse embryonic stem cells.
PG  - 1343-53
LID - 10.1089/scd.2009.0520 [doi]
AB  - We describe a rapid and efficient 5-step program of defined factors for the
      genesis of brain myelin-forming oligodendrocytes (OLs) from embryonic stem cells 
      (ESCs). The OLs emerge on the same time frame in vitro as seen in vivo. Factors
      promoting neural induction (retinoids, noggin) are required, while exogenous
      Sonic hedgehog is not. In contrast we were unable to generate OLs by
      trans-differentiation of ethically neutral mesenchymal stem cells, indicating a
      requirement for cis-differentiation via neural ectoderm for OL genesis. In the
      ESC-derived cultures, our optimized protocol generated a mixed population with
      49% O4(+), Olig2(+) OL lineage cells. These cultures also retained pluripotential
      markers including Oct4, and an analysis of embryoid body formation in vitro, and 
      allogeneic grafts in vivo, revealed that the ESC-derived cultures also retained
      teratogenic cells. The frequency of embryoid body formation from terminal
      differentiated OL cultures was 0.001%, 100-fold lower than that from ESCs. Our
      results provide the first quantitative measurement of teratogenicity in
      ESC-derived, exhaustively differentiated allogeneic grafts, and demonstrate the
      unequivocal need to purify ESC-derived cells in order to generate a safe
      population for regenerative therapy.
FAU - Sadowski, Dorota
AU  - Sadowski D
AD  - Department of Surgery (Neurosurgery), UMDNJ-Robert Wood Johnson Medical School,
      Piscataway, New Jersey 08854, USA.
FAU - Kiel, Mary E
AU  - Kiel ME
FAU - Apicella, Marisa
AU  - Apicella M
FAU - Arriola, Aileen G
AU  - Arriola AG
FAU - Chen, Cui Ping
AU  - Chen CP
FAU - McKinnon, Randall D
AU  - McKinnon RD
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Stem Cells Dev
JT  - Stem cells and development
JID - 101197107
RN  - 0 (Culture Media, Conditioned)
RN  - 0 (Platelet-Derived Growth Factor)
RN  - 0 (Teratogens)
RN  - 0 (platelet-derived growth factor A)
RN  - 103107-01-3 (Fibroblast Growth Factor 2)
SB  - IM
MH  - Animals
MH  - Calibration
MH  - Cell Culture Techniques/standards
MH  - Cell Differentiation/*drug effects/genetics
MH  - Cells, Cultured
MH  - Culture Media, Conditioned/pharmacology
MH  - Drug Evaluation, Preclinical/standards
MH  - Embryonic Stem Cells/*drug effects/metabolism/physiology
MH  - Fibroblast Growth Factor 2/pharmacology
MH  - Gene Expression Regulation, Developmental/drug effects
MH  - Mice
MH  - Models, Biological
MH  - Neurogenesis/drug effects/genetics/physiology
MH  - Oligodendroglia/*drug effects/metabolism/physiology
MH  - Platelet-Derived Growth Factor/pharmacology
MH  - Teratogens/*analysis/*pharmacology
EDAT- 2010/02/06 06:00
MHDA- 2011/01/25 06:00
CRDT- 2010/02/06 06:00
PHST- 2010/02/06 06:00 [entrez]
PHST- 2010/02/06 06:00 [pubmed]
PHST- 2011/01/25 06:00 [medline]
AID - 10.1089/scd.2009.0520 [doi]
PST - ppublish
SO  - Stem Cells Dev. 2010 Sep;19(9):1343-53. doi: 10.1089/scd.2009.0520.


PMID- 20131962
OWN - NLM
STAT- MEDLINE
DCOM- 20100719
LR  - 20161021
IS  - 1460-6984 (Electronic)
IS  - 1368-2822 (Linking)
VI  - 45
IP  - 3
DP  - 2010 May-Jun
TI  - Beginning to teach the end: the importance of including discharge from aphasia
      therapy in the curriculum.
PG  - 263-74
LID - 10.3109/13682820902994200 [doi]
AB  - BACKGROUND: Discharging clients with long-term aphasia from therapy services
      constitutes a challenging dilemma for practising clinicians for a multitude of
      reasons. Although discharge was raised and discussed as a contentious issue in
      the field of aphasiology ten years ago, it remains an aspect of practice which is
      complex and underexplored. We are only a little more enlightened now than then on
      how to address this issue in relation to professional education and practice.
      AIMS: This paper draws on a single case study of a man with aphasia, his wife,
      and treating clinician, taken from a substantial research study, to highlight
      awareness of how communication, choice and differing perceptions of goals of
      therapy influence the experience of the discharge process. The case serves as the
      context for addressing a gap in the university curriculum around teaching about
      discharge practice in the context of long-term aphasia. METHODS & PROCEDURES:
      This paper describes how university and practice educators could include
      discharge issues in students' learning by teaching discharge in context,
      addressing it in formal university lessons as well as through work-based learning
      opportunities in clinical placements, and by scaffolding learning using graduated
      learning outcomes over the different stages of the students' programme. MAIN
      CONTRIBUTION: This paper provides practical suggestions to guide the inclusion of
      discharge in teaching about communication disorders generally, and specifically
      in relation to long-term aphasia. Discharge needs to be appreciated within the
      context of the entire intervention process, with good practice modelled in both
      university and workplace settings. We propose that it is learned in association
      with stages of decision-making, duty of care, documentation, goal setting,
      continuous therapy evaluation, clinical reasoning, professional communication
      with clients, ethical behaviour, and evidence-based practice. CONCLUSIONS &
      IMPLICATIONS: Bringing discharge practice from the realm of implicit knowledge to
      one that can be examined and discussed in an explicit manner should help reduce
      anxieties about discharge for new clinicians, help to clarify and improve the
      discharge approaches used by clinicians and lead to better discharge experiences 
      for clients.
FAU - Hersh, Deborah
AU  - Hersh D
AD  - School of Health and Rehabilitation Sciences, University of Queensland, St Lucia,
      Brisbane, QLD, Australia. deborah.hersh@gmail.com
FAU - Cruice, Madeline
AU  - Cruice M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Int J Lang Commun Disord
JT  - International journal of language & communication disorders
JID - 9803709
SB  - IM
MH  - Aged
MH  - Aphasia/*therapy
MH  - Communication
MH  - Communication Disorders/therapy
MH  - Education, Graduate/methods
MH  - Goals
MH  - Humans
MH  - Male
MH  - Professional-Family Relations
MH  - Professional-Patient Relations
MH  - Speech-Language Pathology/*education/*methods
MH  - Spouses
EDAT- 2010/02/06 06:00
MHDA- 2010/07/20 06:00
CRDT- 2010/02/06 06:00
PHST- 2010/02/06 06:00 [entrez]
PHST- 2010/02/06 06:00 [pubmed]
PHST- 2010/07/20 06:00 [medline]
AID - 10.3109/13682820902994200 [doi]
PST - ppublish
SO  - Int J Lang Commun Disord. 2010 May-Jun;45(3):263-74. doi:
      10.3109/13682820902994200.


PMID- 20131763
OWN - NLM
STAT- MEDLINE
DCOM- 20100623
LR  - 20191210
IS  - 1520-5215 (Electronic)
IS  - 1089-5639 (Linking)
VI  - 114
IP  - 10
DP  - 2010 Mar 18
TI  - Potential energy surfaces fitted by artificial neural networks.
PG  - 3371-83
LID - 10.1021/jp9105585 [doi]
AB  - Molecular mechanics is the tool of choice for the modeling of systems that are so
      large or complex that it is impractical or impossible to model them by ab initio 
      methods. For this reason there is a need for accurate potentials that are able to
      quickly reproduce ab initio quality results at the fraction of the cost. The
      interactions within force fields are represented by a number of functions. Some
      interactions are well understood and can be represented by simple mathematical
      functions while others are not so well understood and their functional form is
      represented in a simplistic manner or not even known. In the last 20 years there 
      have been the first examples of a new design ethic, where novel and contemporary 
      methods using machine learning, in particular, artificial neural networks, have
      been used to find the nature of the underlying functions of a force field. Here
      we appraise what has been achieved over this time and what requires further
      improvements, while offering some insight and guidance for the development of
      future force fields.
FAU - Handley, Chris M
AU  - Handley CM
AD  - Manchester Interdisciplinary Biocentre, 131 Princess Street, Manchester M1 7DN,
      Great Britain.
FAU - Popelier, Paul L A
AU  - Popelier PL
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Phys Chem A
JT  - The journal of physical chemistry. A
JID - 9890903
SB  - IM
MH  - Computer Simulation
MH  - Molecular Dynamics Simulation
MH  - *Neural Networks, Computer
MH  - *Thermodynamics
RF  - 52
EDAT- 2010/02/06 06:00
MHDA- 2010/06/24 06:00
CRDT- 2010/02/06 06:00
PHST- 2010/02/06 06:00 [entrez]
PHST- 2010/02/06 06:00 [pubmed]
PHST- 2010/06/24 06:00 [medline]
AID - 10.1021/jp9105585 [doi]
PST - ppublish
SO  - J Phys Chem A. 2010 Mar 18;114(10):3371-83. doi: 10.1021/jp9105585.


PMID- 20131530
OWN - NLM
STAT- MEDLINE
DCOM- 20100311
LR  - 20161202
IS  - 2376-4317 (Print)
IS  - 2376-4317 (Linking)
VI  - 17
IP  - 1
DP  - 2010 Jan-Mar
TI  - Ethical and legal resources that relate to lateral violence.
PG  - 5
FAU - Dulaney, Peggy
AU  - Dulaney P
LA  - eng
PT  - Journal Article
PL  - United States
TA  - S C Nurse (1994)
JT  - South Carolina nurse (Columbia, S.C. : 1994)
JID - 9423819
MH  - *Codes of Ethics
MH  - Humans
MH  - *Interprofessional Relations/ethics
MH  - *Legislation, Nursing
MH  - *Nurses
MH  - *Social Behavior
MH  - South Carolina
MH  - Violence/ethics/legislation & jurisprudence/*prevention & control
EDAT- 2010/02/06 06:00
MHDA- 2010/03/12 06:00
CRDT- 2010/02/06 06:00
PHST- 2010/02/06 06:00 [entrez]
PHST- 2010/02/06 06:00 [pubmed]
PHST- 2010/03/12 06:00 [medline]
PST - ppublish
SO  - S C Nurse (1994). 2010 Jan-Mar;17(1):5.


PMID- 20131179
OWN - NLM
STAT- MEDLINE
DCOM- 20100315
LR  - 20191210
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 2
DP  - 2010 Feb
TI  - Ethics and research in the service of asylum seekers.
PG  - 63-5
LID - 10.1080/15265160903506400 [doi]
FAU - Strous, Rael D
AU  - Strous RD
AD  - Tel Aviv University, Israel. raels@post.tau.ac.il
FAU - Jotkowitz, Alan
AU  - Jotkowitz A
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2010 Feb;10(2):48-56. PMID: 20131175
MH  - Australia
MH  - Conflict, Psychological
MH  - Ethics, Research
MH  - *Health Services Research/ethics/standards/trends
MH  - *Human Rights
MH  - Humans
MH  - Informed Consent/ethics
MH  - Narration
MH  - *Patient Advocacy/psychology
MH  - Personal Autonomy
MH  - *Prisoners
MH  - Prisons
MH  - *Refugees
MH  - Research Personnel/ethics
MH  - *Research Subjects/psychology
MH  - *Vulnerable Populations
EDAT- 2010/02/05 06:00
MHDA- 2010/03/17 06:00
CRDT- 2010/02/05 06:00
PHST- 2010/02/05 06:00 [entrez]
PHST- 2010/02/05 06:00 [pubmed]
PHST- 2010/03/17 06:00 [medline]
AID - 919061800 [pii]
AID - 10.1080/15265160903506400 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Feb;10(2):63-5. doi: 10.1080/15265160903506400.


PMID- 20131175
OWN - NLM
STAT- MEDLINE
DCOM- 20100315
LR  - 20191210
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 2
DP  - 2010 Feb
TI  - Returning to history: the ethics of researching asylum seeker health in
      Australia.
PG  - 48-56
LID - 10.1080/15265160903469310 [doi]
AB  - Australia's policy of mandatory indefinite detention of those seeking asylum and 
      arriving without valid documents has led to terrible human rights abuses and
      cumulative deterioration in health for those incarcerated. We argue that there is
      an imperative to research and document the plight of those who have suffered at
      the hands of the Australian government and its agents. However, the normal tools 
      available to those engaged in health research may further erode the rights and
      well being of this population, requiring a rethink of existing research ethics
      paradigms to approaches that foster advocacy research and drawing on the voices
      of those directly affected, including those bestowed with duty of care for this
      population.
FAU - Zion, Deborah
AU  - Zion D
AD  - Monash University, Melbourne, Victoria, Australia. deborah.zion@med.monash.edu.au
FAU - Briskman, Linda
AU  - Briskman L
FAU - Loff, Bebe
AU  - Loff B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CIN - Am J Bioeth. 2010 Feb;10(2):W6-7. PMID: 20131161
CIN - Am J Bioeth. 2010 Feb;10(2):57-8. PMID: 20131176
CIN - Am J Bioeth. 2010 Feb;10(2):59-60. PMID: 20131177
CIN - Am J Bioeth. 2010 Feb;10(2):61-2. PMID: 20131178
CIN - Am J Bioeth. 2010 Feb;10(2):63-5. PMID: 20131179
CIN - Am J Bioeth. 2010 Feb;10(2):65-7. PMID: 20131180
MH  - Australia
MH  - *Behavior Control
MH  - Coercion
MH  - Conflict, Psychological
MH  - Ethics, Research
MH  - *Health Services Accessibility/ethics
MH  - *Human Rights
MH  - Humans
MH  - *Informed Consent/ethics
MH  - Narration
MH  - *Patient Advocacy/psychology
MH  - Personal Autonomy
MH  - *Prisoners
MH  - Prisons
MH  - Private Sector
MH  - *Refugees
MH  - *Research Personnel/ethics/psychology
MH  - *Research Subjects/psychology
MH  - Time Factors
MH  - Uncertainty
MH  - *Vulnerable Populations
EDAT- 2010/02/05 06:00
MHDA- 2010/03/17 06:00
CRDT- 2010/02/05 06:00
PHST- 2010/02/05 06:00 [entrez]
PHST- 2010/02/05 06:00 [pubmed]
PHST- 2010/03/17 06:00 [medline]
AID - 919062977 [pii]
AID - 10.1080/15265160903469310 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Feb;10(2):48-56. doi: 10.1080/15265160903469310.


PMID- 20131170
OWN - NLM
STAT- MEDLINE
DCOM- 20100315
LR  - 20100204
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 2
DP  - 2010 Feb
TI  - Blood donation, deferral, and discrimination: FDA donor deferral policy for men
      who have sex with men.
PG  - 29-39
LID - 10.1080/15265161.2010.520590 [doi]
AB  - U.S. Food and Drug Administration (FDA) policy prohibits blood donation from men 
      who have had sex with men (MSM) even one time since 1977. Growing moral criticism
      claims that this policy is discriminatory, a claim rejected by the FDA. An
      overview of U.S. blood donation, recent donor deferral policy, and the
      conventional ethical debate introduce the need for a different approach to
      analyzing discrimination claims. I draw on an institutional understanding of
      injustice to discern and describe five features of the MSM policy and its FDA
      context that contribute to its discriminatory effect. I note significant
      similarities in the 1980s policy of deferring Haitians, suggesting an historical 
      pattern of discrimination in FDA deferral policy. Finally, I point to changes
      needed to move toward a nondiscriminatory deferral policy.
FAU - Galarneau, Charlene
AU  - Galarneau C
AD  - Wellesley College, Women's and Gender Studies Department, Wellesley, MA 02481,
      USA. cgalarne@wellesley.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CIN - Am J Bioeth. 2010 Feb;10(2):W4-5. PMID: 20131160
CIN - Am J Bioeth. 2010 Feb;10(2):40-2. PMID: 20131171
CIN - Am J Bioeth. 2010 Feb;10(2):42-3. PMID: 20131172
CIN - Am J Bioeth. 2010 Feb;10(2):44-5. PMID: 20131173
CIN - Am J Bioeth. 2010 Feb;10(2):46-7. PMID: 20131174
MH  - Blood Donors/ethics/*legislation & jurisprudence
MH  - Donor Selection/ethics/*legislation & jurisprudence/*standards/trends
MH  - Ethical Analysis
MH  - HIV Infections/*prevention & control/transmission
MH  - Haiti
MH  - Health Policy/legislation & jurisprudence/*trends
MH  - *Homosexuality, Male
MH  - Humans
MH  - Male
MH  - *Prejudice
MH  - Risk Assessment
MH  - Risk Factors
MH  - Safety
MH  - *Sexual Behavior
MH  - Sexual Partners
MH  - Social Justice
MH  - Time Factors
MH  - United States
MH  - United States Food and Drug Administration
EDAT- 2010/02/05 06:00
MHDA- 2010/03/17 06:00
CRDT- 2010/02/05 06:00
PHST- 2010/02/05 06:00 [entrez]
PHST- 2010/02/05 06:00 [pubmed]
PHST- 2010/03/17 06:00 [medline]
AID - 919062621 [pii]
AID - 10.1080/15265161.2010.520590 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Feb;10(2):29-39. doi: 10.1080/15265161.2010.520590.


PMID- 20131167
OWN - NLM
STAT- MEDLINE
DCOM- 20100315
LR  - 20100204
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 2
DP  - 2010 Feb
TI  - Transplant tourism from Taiwan to China: some reflection on professional ethics
      and regulation.
PG  - 22-4
LID - 10.1080/15265160903531291 [doi]
FAU - Tsai, Daniel Fu Chang
AU  - Tsai DF
AD  - Department of Social Medicine, College of Medicine, National Taiwan University,
      Taipei, Taiwan, R.O.C. fctsai@ntu.edu.tw
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2010 Feb;10(2):3-11. PMID: 20131159
MH  - Beneficence
MH  - Cadaver
MH  - China/epidemiology
MH  - Commerce/*ethics
MH  - Commodification
MH  - Developed Countries
MH  - Developing Countries
MH  - Ethics, Medical
MH  - Humans
MH  - Informed Consent
MH  - Kidney Failure, Chronic/epidemiology/surgery
MH  - Kidney Transplantation/legislation & jurisprudence/statistics & numerical data
MH  - Liver Transplantation/legislation & jurisprudence/statistics & numerical data
MH  - *Medical Tourism/statistics & numerical data
MH  - Moral Obligations
MH  - Organ Transplantation/economics/ethics/*legislation & jurisprudence/*statistics &
      numerical data
MH  - *Prisoners
MH  - Taiwan/epidemiology
MH  - *Wedge Argument
EDAT- 2010/02/05 06:00
MHDA- 2010/03/17 06:00
CRDT- 2010/02/05 06:00
PHST- 2010/02/05 06:00 [entrez]
PHST- 2010/02/05 06:00 [pubmed]
PHST- 2010/03/17 06:00 [medline]
AID - 919063493 [pii]
AID - 10.1080/15265160903531291 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Feb;10(2):22-4. doi: 10.1080/15265160903531291.


PMID- 20131165
OWN - NLM
STAT- MEDLINE
DCOM- 20100315
LR  - 20100204
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 2
DP  - 2010 Feb
TI  - Professional and public ethics united in condemnation of transplant tourism.
PG  - 18-20
LID - 10.1080/15265160903506376 [doi]
FAU - Martin, Dominique
AU  - Martin D
AD  - Centre for Applied Philosophy and Public Ethics, University of Melbourne,
      Carlton, Victoria, Australia. domini.martin@gmail.com
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2010 Feb;10(2):3-11. PMID: 20131159
MH  - *Beneficence
MH  - Capital Punishment
MH  - *Ethics, Medical
MH  - Health Policy/trends
MH  - Humans
MH  - *Medical Tourism/ethics
MH  - Moral Obligations
MH  - Organ Transplantation/adverse effects/*ethics
MH  - *Prisoners
MH  - *Social Justice/ethics/standards/trends
MH  - Societies, Medical
MH  - Tissue and Organ Procurement/*ethics
EDAT- 2010/02/05 06:00
MHDA- 2010/03/17 06:00
CRDT- 2010/02/05 06:00
PHST- 2010/02/05 06:00 [entrez]
PHST- 2010/02/05 06:00 [pubmed]
PHST- 2010/03/17 06:00 [medline]
AID - 919059404 [pii]
AID - 10.1080/15265160903506376 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Feb;10(2):18-20. doi: 10.1080/15265160903506376.


PMID- 20131162
OWN - NLM
STAT- MEDLINE
DCOM- 20100315
LR  - 20100204
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 2
DP  - 2010 Feb
TI  - The transplant surgeon and transplant tourists: ethical and surgical issues.
PG  - 12-3
LID - 10.1080/15265160903506434 [doi]
FAU - Testa, Giuliano
AU  - Testa G
AD  - University of Chicago Medical Center, Chicago, IL, USA.
FAU - Angelos, Peter
AU  - Angelos P
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2010 Feb;10(2):3-11. PMID: 20131159
MH  - Beneficence
MH  - Capital Punishment
MH  - China
MH  - Commerce/ethics/*legislation & jurisprudence
MH  - *Ethics, Medical
MH  - Humans
MH  - *Informed Consent
MH  - Internationality
MH  - Judgment
MH  - *Living Donors
MH  - *Medical Tourism/ethics/trends
MH  - Moral Obligations
MH  - Organ Transplantation/adverse effects/economics/*ethics/legislation &
      jurisprudence/standards/trends
MH  - Physicians/ethics
MH  - Prisoners
MH  - Program Development/*standards
MH  - Social Responsibility
MH  - Tissue and Organ Procurement/*ethics
MH  - United States
EDAT- 2010/02/05 06:00
MHDA- 2010/03/17 06:00
CRDT- 2010/02/05 06:00
PHST- 2010/02/05 06:00 [entrez]
PHST- 2010/02/05 06:00 [pubmed]
PHST- 2010/03/17 06:00 [medline]
AID - 919059690 [pii]
AID - 10.1080/15265160903506434 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Feb;10(2):12-3. doi: 10.1080/15265160903506434.


PMID- 20131161
OWN - NLM
STAT- MEDLINE
DCOM- 20100315
LR  - 20191210
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 2
DP  - 2010 Feb
TI  - Response to open peer commentaries on "Returning to history: the ethics of
      researching asylum seeker health in Australia".
PG  - W6-7
LID - 10.1080/15265160903547511 [doi]
FAU - Zion, Deborah
AU  - Zion D
AD  - Monash University, Melbourne, Victoria, Australia. deborah.zion@med.monash.edu.au
FAU - Briskman, Linda
AU  - Briskman L
FAU - Loff, Bebe
AU  - Loff B
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2010 Feb;10(2):48-56. PMID: 20131175
MH  - Australia
MH  - *Behavior Control
MH  - Coercion
MH  - Conflict, Psychological
MH  - Ethics, Research
MH  - *Health Services Accessibility/ethics
MH  - *Human Rights
MH  - Humans
MH  - *Informed Consent/ethics
MH  - Narration
MH  - *Patient Advocacy/psychology
MH  - Personal Autonomy
MH  - *Prisoners
MH  - Prisons
MH  - *Refugees
MH  - *Research Personnel/ethics/psychology
MH  - *Research Subjects/psychology
MH  - Time Factors
MH  - Uncertainty
MH  - *Vulnerable Populations
EDAT- 2010/02/05 06:00
MHDA- 2010/03/17 06:00
CRDT- 2010/02/05 06:00
PHST- 2010/02/05 06:00 [entrez]
PHST- 2010/02/05 06:00 [pubmed]
PHST- 2010/03/17 06:00 [medline]
AID - 919061873 [pii]
AID - 10.1080/15265160903547511 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Feb;10(2):W6-7. doi: 10.1080/15265160903547511.


PMID- 20130836
OWN - NLM
STAT- MEDLINE
DCOM- 20110210
LR  - 20211020
IS  - 1433-7347 (Electronic)
IS  - 0942-2056 (Linking)
VI  - 18
IP  - 11
DP  - 2010 Nov
TI  - A comparison of intraarticular morphine and bupivacaine for pain control and
      outpatient status after an arthroscopic knee surgery under a low dose of spinal
      anaesthesia.
PG  - 1487-95
LID - 10.1007/s00167-010-1061-0 [doi]
AB  - Effective pain control is important after an outpatient arthroscopic knee surgery
      to permit early discharge and improve outcome. The aim of this study was to
      compare intraarticular morphine and bupivacaine with placebo for postoperative
      pain control and outpatient status after a knee arthroscopic surgery under a low 
      dose of spinal anaesthesia. After obtaining the ethic committee's approval and
      written informed consents from 60 adult outpatients undergoing knee arthroscopy, 
      patients were enrolled in this prospective, randomized, double-blinded,
      placebo-controlled clinical study. All patients received spinal anaesthesia with 
      1.4 ml of hyperbaric bupivacaine 0.5%. Patients were randomly divided into three 
      groups as morphine (group M, n =20), bupivacaine (group B, n = 20), and placebo
      (group C, n = 20). After the surgical procedure, patients received one of the
      following solutions intraarticularly in a double-blinded randomized manner: 5 mg 
      morphine in 20 ml saline, 20 ml 0.25% bupivacaine, or 20 ml saline. Postoperative
      pain was assessed using a 10-cm visual analogue scale (VAS). Patient
      characteristics, hemodynamic values, sensory and motor blocks, VAS values, rescue
      analgesics, discharge time, and patient satisfaction were recorded. There were no
      significant differences in patient characteristics, surgery and tourniquet time, 
      hemodynamic values, and sensory and motor blocks. The VAS values at 30, 60, and
      90 min were similar among the three groups. The VAS values at rest and during
      move were higher in group C than in groups M and B at 120, 150, 180 min, and 24 h
      (P < 0.001). There was no difference in VAS values between the groups M and B.
      Rescue analgesics used and discharge time were significantly different in the
      placebo group when compared to groups M and B (P < 0.001). Side effects were
      similar among the groups. Patient satisfaction scores were high in the groups M
      and B. Administration of 5 mg morphine and 20 ml of 0.25% bupivacaine
      intraarticularly provides better pain relief and shorter discharge time without
      increasing the side effects than placebo for an outpatient arthroscopic knee
      surgery performed under a low dose of spinal anaesthesia.
FAU - Eroglu, Ahmet
AU  - Eroglu A
AD  - Department of Anaesthesiology and Reanimation, Faculty of Medicine, Karadeniz
      Technical University, Trabzon, Turkey. erogluah@hotmail.com
FAU - Saracoglu, Sebnem
AU  - Saracoglu S
FAU - Erturk, Engin
AU  - Erturk E
FAU - Kosucu, Muge
AU  - Kosucu M
FAU - Kerimoglu, Servet
AU  - Kerimoglu S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20100204
PL  - Germany
TA  - Knee Surg Sports Traumatol Arthrosc
JT  - Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
JID - 9314730
RN  - 76I7G6D29C (Morphine)
RN  - Y8335394RO (Bupivacaine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Ambulatory Surgical Procedures/methods
MH  - Anesthesia, Spinal/methods
MH  - Arthroscopy/adverse effects/*methods
MH  - Bupivacaine/*administration & dosage
MH  - Dose-Response Relationship, Drug
MH  - Double-Blind Method
MH  - Drug Administration Schedule
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Injections, Intra-Articular
MH  - Knee Joint/physiopathology/*surgery
MH  - Male
MH  - Middle Aged
MH  - Morphine/*administration & dosage
MH  - Pain Measurement/*drug effects
MH  - Pain, Postoperative/diagnosis/*drug therapy
MH  - Postoperative Care/methods
MH  - Prospective Studies
MH  - Time Factors
MH  - Young Adult
EDAT- 2010/02/05 06:00
MHDA- 2011/02/11 06:00
CRDT- 2010/02/05 06:00
PHST- 2009/09/21 00:00 [received]
PHST- 2010/01/11 00:00 [accepted]
PHST- 2010/02/05 06:00 [entrez]
PHST- 2010/02/05 06:00 [pubmed]
PHST- 2011/02/11 06:00 [medline]
AID - 10.1007/s00167-010-1061-0 [doi]
PST - ppublish
SO  - Knee Surg Sports Traumatol Arthrosc. 2010 Nov;18(11):1487-95. doi:
      10.1007/s00167-010-1061-0. Epub 2010 Feb 4.


PMID- 20129994
OWN - NLM
STAT- MEDLINE
DCOM- 20100617
LR  - 20220309
IS  - 1460-2350 (Electronic)
IS  - 0268-1161 (Linking)
VI  - 25
IP  - 4
DP  - 2010 Apr
TI  - Should access to fertility treatment be determined by female body mass index?
PG  - 815-20
LID - 10.1093/humrep/deq013 [doi]
AB  - Resource allocation towards fertility treatment has been extensively debated in
      countries where fertility treatment is publicly-funded. Medical, social and
      ethical aspects have been evaluated prior to allocation of resources. Analysis of
      cost-effectiveness, risks and benefits and poor success rates have led to calls
      of restricting fertility treatment to obese women. In this debate article, we
      critically appraise the evidence underlying this issue and highlight the problems
      with such a policy. Poor success rate of treatment is unsubstantiated as there is
      insufficient evidence to link high body mass index (BMI) to reduction in live
      birth. Obstetric complications have a linear relationship with BMI but are
      significantly influenced by maternal age. The same is true for miscarriage rates 
      which are influenced by the confounding factors of polycystic ovary syndrome and 
      age. Studies have shown that the direct costs per live birth are no greater for
      overweight and obese women. With changing demographics over half the
      reproductive-age population is overweight or obese. Restricting fertility
      treatment on the grounds of BMI would cause stigmatization and lead to inequity, 
      feelings of injustice and social tension as affluent women manage to bypass these
      draconian restrictions. Time lost and poor success of conventional weight loss
      strategies would jeopardize the chances of conception for many women.
FAU - Pandey, S
AU  - Pandey S
AD  - Assisted Reproduction Unit, University of Aberdeen, Aberdeen Maternity Hospital, 
      Forresterhill Road, Aberdeen AB25 2ZL, UK. s.pandey@abdn.ac.uk
FAU - Maheshwari, A
AU  - Maheshwari A
FAU - Bhattacharya, S
AU  - Bhattacharya S
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100203
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
SB  - IM
MH  - Adult
MH  - *Body Mass Index
MH  - Costs and Cost Analysis
MH  - Counseling
MH  - Female
MH  - *Health Services Accessibility
MH  - Humans
MH  - Infertility/complications/therapy
MH  - Obesity/complications
MH  - Overweight/complications
MH  - Pregnancy
MH  - Pregnancy Complications/etiology
MH  - *Reproductive Techniques, Assisted/economics
RF  - 64
EDAT- 2010/02/05 06:00
MHDA- 2010/06/18 06:00
CRDT- 2010/02/05 06:00
PHST- 2010/02/05 06:00 [entrez]
PHST- 2010/02/05 06:00 [pubmed]
PHST- 2010/06/18 06:00 [medline]
AID - deq013 [pii]
AID - 10.1093/humrep/deq013 [doi]
PST - ppublish
SO  - Hum Reprod. 2010 Apr;25(4):815-20. doi: 10.1093/humrep/deq013. Epub 2010 Feb 3.


PMID- 20129800
OWN - NLM
STAT- MEDLINE
DCOM- 20110414
LR  - 20191210
IS  - 1879-1336 (Electronic)
IS  - 1054-8807 (Linking)
VI  - 20
IP  - 1
DP  - 2011 Jan-Feb
TI  - Aneurysms in the arteries of the upper extremity in a Kenyan population.
PG  - e53-6
LID - 10.1016/j.carpath.2010.01.009 [doi]
AB  - BACKGROUND: Aneurysms in the arteries of the upper extremity are rare but
      important in predicting aortic aneurysms and their potential to thromboembolize
      and cause limb loss. Their localization, age, and gender distribution vary
      between countries depending on ethnic background and cause. These data are
      valuable in the management of aneurysms, but are largely lacking from the Kenyan 
      population. OBJECTIVE: This study aimed at examining the pattern of these
      aneurysms in a Kenyan population. STUDY DESIGN: Retrospective. SETTING: Kenyatta 
      National Hospital, Kenya. PATIENTS AND METHODS: Hospital records of aneurysms in 
      upper limb arteries over 10 years from January 1998 to December 2007 were
      examined. Ethical approval was given by the Kenyatta National Hospital Ethics and
      Research Committee. Site, age, gender, and risk factors were recorded.
      Unconfirmed diagnoses were excluded. Results were analyzed using SPSS 11.50 and
      presented using tables. RESULTS: Aneurysms of the upper extremity arteries
      comprise 34 (35.4%) out of 96 peripheral aneurysms. Of these, brachial artery was
      the most common site (35.3%), followed by brachiocephalic (11, 32.4%), subclavian
      (9, 26.5%), radial (1, 2.9%), and anterior interosseous (1, 2.9%). Trauma was the
      commonest predisposing factor (41.2%), followed by atherosclerosis and related
      comorbidities (32.4%), infection (11.8%), and autoimmune disease (8.8%). The mean
      age was 39.5 years (range: 13-79) with a variable gender distribution.
      CONCLUSION: Aneurysms of the upper extremity arteries are not uncommon in the
      Kenyan population. They occur more commonly in individuals aged 50 years and
      less, and although most of them are traumatic, atherosclerosis constitutes a
      significant proportion. Prudent management of risk factors is recommended.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Ogeng'o, Julius A
AU  - Ogeng'o JA
AD  - Department of Human Anatomy, University of Nairobi, PO Box 00100, Nairobi 30197, 
      Kenya. jogengo@uonbi.ac.ke
FAU - Otieno, Beda
AU  - Otieno B
LA  - eng
PT  - Journal Article
DEP - 20100202
PL  - United States
TA  - Cardiovasc Pathol
JT  - Cardiovascular pathology : the official journal of the Society for Cardiovascular
      Pathology
JID - 9212060
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aneurysm/*epidemiology/etiology
MH  - Aortic Aneurysm/etiology
MH  - Arm/*blood supply
MH  - Arm Injuries/complications
MH  - Atherosclerosis/complications
MH  - Autoimmune Diseases/complications
MH  - Brachial Artery
MH  - Brachiocephalic Trunk
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Infections/complications
MH  - Kenya/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Radial Artery
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Subclavian Artery
MH  - Thromboembolism/etiology
MH  - Wounds and Injuries
MH  - Young Adult
EDAT- 2010/02/05 06:00
MHDA- 2011/04/16 06:00
CRDT- 2010/02/05 06:00
PHST- 2009/09/02 00:00 [received]
PHST- 2010/01/04 00:00 [revised]
PHST- 2010/01/07 00:00 [accepted]
PHST- 2010/02/05 06:00 [entrez]
PHST- 2010/02/05 06:00 [pubmed]
PHST- 2011/04/16 06:00 [medline]
AID - S1054-8807(10)00025-6 [pii]
AID - 10.1016/j.carpath.2010.01.009 [doi]
PST - ppublish
SO  - Cardiovasc Pathol. 2011 Jan-Feb;20(1):e53-6. doi: 10.1016/j.carpath.2010.01.009. 
      Epub 2010 Feb 2.


PMID- 20129342
OWN - NLM
STAT- MEDLINE
DCOM- 20100309
LR  - 20100204
IS  - 1553-4650 (Print)
IS  - 1553-4650 (Linking)
VI  - 17
IP  - 1
DP  - 2010 Jan-Feb
TI  - Laparoscopic resection of endometriosis in a patient with a ventriculoperitoneal 
      shunt using the LapDisc.
PG  - 107-9
LID - 10.1016/j.jmig.2009.09.014 [doi]
AB  - The surgical approach in a patient with a ventriculoperitoneal shunt in need of
      abdominal surgery remains controversial. The risk of increased intracranial
      pressure with pneumoperitoneum in laparoscopy is still unresolved. We used the
      LapDisc (Ethicon, Inc., Somerville, New Jersey) to access the shunt and
      temporarily seal it, which enabled us to perform laparoscopic resection of
      endometriosis without subjecting the shunt to high intraabdominal pressure. The
      benefits of this approach are the ability to perform laparoscopy, less
      skin-to-shunt contact minimizing infection, and elimination of possible increased
      intracranial pressure secondary to pneumoperitoneum. With the progress made in
      the management of hydrocephalus, patients with ventriculoperitoneal (VP) shunts
      enjoy a longer lifespan. Therefore, the gynecologic laparoscopic surgeon can
      expect to treat a patient with a VP shunt in place.
CI  - Copyright (c) 2010 AAGL. Published by Elsevier Inc. All rights reserved.
FAU - Orbuch, Iris Kerin
AU  - Orbuch IK
AD  - Department of Obstetrics and Gynecology, Lenox Hill Hospital, New York, New York 
      10012, USA. irisorbuch@gmail.com
FAU - Atkin, Russell
AU  - Atkin R
FAU - Filmar, Gilad
AU  - Filmar G
FAU - Singer, Tomer
AU  - Singer T
FAU - Divon, Michael Y
AU  - Divon MY
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Minim Invasive Gynecol
JT  - Journal of minimally invasive gynecology
JID - 101235322
SB  - IM
MH  - Adult
MH  - Endometriosis/*surgery
MH  - Female
MH  - Humans
MH  - *Laparoscopes
MH  - Laparoscopy/*methods
MH  - Peritoneal Diseases/*surgery
MH  - Treatment Outcome
MH  - *Ventriculoperitoneal Shunt
EDAT- 2010/02/05 06:00
MHDA- 2010/03/10 06:00
CRDT- 2010/02/05 06:00
PHST- 2009/07/09 00:00 [received]
PHST- 2009/09/17 00:00 [revised]
PHST- 2009/09/24 00:00 [accepted]
PHST- 2010/02/05 06:00 [entrez]
PHST- 2010/02/05 06:00 [pubmed]
PHST- 2010/03/10 06:00 [medline]
AID - S1553-4650(09)01088-7 [pii]
AID - 10.1016/j.jmig.2009.09.014 [doi]
PST - ppublish
SO  - J Minim Invasive Gynecol. 2010 Jan-Feb;17(1):107-9. doi:
      10.1016/j.jmig.2009.09.014.


PMID- 20129322
OWN - NLM
STAT- MEDLINE
DCOM- 20100416
LR  - 20100204
IS  - 1552-5279 (Electronic)
IS  - 1552-5260 (Linking)
VI  - 6
IP  - 1
DP  - 2010 Jan
TI  - Early dementia diagnosis and the risk of suicide and euthanasia.
PG  - 75-82
LID - 10.1016/j.jalz.2009.04.1229 [doi]
AB  - BACKGROUND: Diagnosis of dementia is occurring earlier, and much research
      concerns the identification of predementia states and the hunt for biomarkers of 
      Alzheimer's disease. Reports of suicidal behavior and requests for euthanasia in 
      persons with dementia may be increasing. METHODS: We performed a selective
      literature review of suicide risk in persons with dementia and the ethical issues
      associated with euthanasia in this population. RESULTS: In the absence of any
      effective treatments for Alzheimer's disease or other types of dementia, there is
      already evidence that persons with mild cognitive change and early dementia are
      at risk of suicidal behavior, often in the context of comorbid depression. The
      ensuing clinical, ethical, and legal dilemmas associated with physician-assisted 
      suicide and euthanasia in the context of dementia are a subject of intense
      debate. By analogy, the preclinical and early diagnoses of Huntington's disease
      are associated with an increased risk of suicidal behavior. Thus there is the
      potential for a preclinical and early diagnosis of Alzheimer's disease (through
      biomarkers, neuroimaging, and clinical assessment) to result in increased suicide
      risk and requests for physician-assisted suicide. CONCLUSIONS: Although dementia 
      specialists have long recognized the importance of a sensitive approach to
      conveying bad news to patients and families and the possibility of depressive
      reactions, suicidal behavior has not been regarded as a likely outcome. Such
      preconceptions will need to change, and protocols to monitor and manage suicide
      risk will need to be developed for this population.
CI  - 2010 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
FAU - Draper, Brian
AU  - Draper B
AD  - University of New South Wales, Sydney, Australia. b.draper@unsw.edu.au
FAU - Peisah, Carmelle
AU  - Peisah C
FAU - Snowdon, John
AU  - Snowdon J
FAU - Brodaty, Henry
AU  - Brodaty H
LA  - eng
PT  - Editorial
PT  - Review
PL  - United States
TA  - Alzheimers Dement
JT  - Alzheimer's & dementia : the journal of the Alzheimer's Association
JID - 101231978
SB  - IM
MH  - Databases, Factual/statistics & numerical data
MH  - Dementia/*diagnosis/*psychology
MH  - Euthanasia/*psychology
MH  - Humans
MH  - Risk
MH  - Suicide/*psychology
MH  - Suicide, Assisted/psychology
RF  - 64
EDAT- 2010/02/05 06:00
MHDA- 2010/04/17 06:00
CRDT- 2010/02/05 06:00
PHST- 2009/01/23 00:00 [received]
PHST- 2009/04/05 00:00 [revised]
PHST- 2009/04/08 00:00 [accepted]
PHST- 2010/02/05 06:00 [entrez]
PHST- 2010/02/05 06:00 [pubmed]
PHST- 2010/04/17 06:00 [medline]
AID - S1552-5260(09)00104-6 [pii]
AID - 10.1016/j.jalz.2009.04.1229 [doi]
PST - ppublish
SO  - Alzheimers Dement. 2010 Jan;6(1):75-82. doi: 10.1016/j.jalz.2009.04.1229.


PMID- 20129229
OWN - NLM
STAT- MEDLINE
DCOM- 20100423
LR  - 20220330
IS  - 1542-2011 (Electronic)
IS  - 1526-9523 (Linking)
VI  - 55
IP  - 1
DP  - 2010 Jan-Feb
TI  - Knowledge of female genital cutting and experience with women who are
      circumcised: a survey of nurse-midwives in the United States.
PG  - 46-54
LID - 10.1016/j.jmwh.2009.01.005 [doi]
AB  - Thousands of women with a history of female genital cutting (FGC) have immigrated
      to the United States. The purpose of this study was to assess certified
      nurse-midwives' (CNMs') knowledge of FGC and to explore their experiences caring 
      for African immigrant women with a history of genital cutting. A descriptive
      survey design was used. A random sample of 600 CNMs from the member list of the
      American College of Nurse-Midwives was surveyed. Two hundred forty-three CNMs
      completed a survey of FGC knowledge and provider experience. The respondents
      exhibited more correct medical knowledge about FGC than knowledge of cultural and
      legal issues. Differences in correct or incorrect knowledge were statistically
      significant based on provider experience. Almost 70% of respondents could
      identify infibulation. Less than 20% knew that both Muslim and Christian women
      are circumcised. Fifty-seven percent knew that it is illegal in the United States
      to circumcise women younger than 18 years of age. We found that discussions
      between CNMs and clients who were circumcised regarding FGC-related concerns and 
      complications were minimal. Women with a history of FGC want female providers.
      Reinfibulation poses an ethical dilemma for some CNMs. Nurse-midwives in the
      United States need to learn more about FGC and the cultures of their clients in
      order to provide culturally competent care.
CI  - Copyright 2010 American College of Nurse-Midwives. Published by Elsevier Inc. All
      rights reserved.
FAU - Hess, Rosanna F
AU  - Hess RF
AD  - Malone University, Canton, OH, USA. rfhess@researchforhealth.org
FAU - Weinland, JoAnn
AU  - Weinland J
FAU - Saalinger, Natalie M
AU  - Saalinger NM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Midwifery Womens Health
JT  - Journal of midwifery & women's health
JID - 100909407
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Circumcision, Female/adverse effects/psychology
MH  - Cross-Cultural Comparison
MH  - *Cultural Competency
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nurse Midwives/*psychology
MH  - Nurse's Role
MH  - Nurse-Patient Relations
MH  - Surveys and Questionnaires
MH  - United States
EDAT- 2010/02/05 06:00
MHDA- 2010/04/24 06:00
CRDT- 2010/02/05 06:00
PHST- 2008/05/16 00:00 [received]
PHST- 2009/01/29 00:00 [revised]
PHST- 2009/01/29 00:00 [accepted]
PHST- 2010/02/05 06:00 [entrez]
PHST- 2010/02/05 06:00 [pubmed]
PHST- 2010/04/24 06:00 [medline]
AID - S1526-9523(09)00043-9 [pii]
AID - 10.1016/j.jmwh.2009.01.005 [doi]
PST - ppublish
SO  - J Midwifery Womens Health. 2010 Jan-Feb;55(1):46-54. doi:
      10.1016/j.jmwh.2009.01.005.


PMID- 20128538
OWN - NLM
STAT- MEDLINE
DCOM- 20100311
LR  - 20100204
IS  - 1940-4921 (Print)
IS  - 1938-2464 (Linking)
VI  - 3
IP  - 1
DP  - 2010 Jan
TI  - Benefits and challenges of electronic surveillance in nursing home research.
PG  - 5-10
LID - 10.3928/19404921-20090706-01 [doi]
AB  - Cognitive impairment and frailty associated with dementia renders residents of
      long-term care (LTC) facilities particularly vulnerable to physical and emotional
      harm. Resident-to-resident violence affects not only the target of the
      aggression, but also the aggressor, as well as the formal and informal caregivers
      who must intervene. To date, little research has been conducted on
      resident-to-resident violence despite preliminary but emerging evidence that it
      is a common (and likely growing) problem in LTC settings. Exploration of this
      phenomenon presents multiple pragmatic and ethical challenges. This article
      presents a rationale for implementing newer technological methods to collect data
      in investigations of resident-to-resident violence associated with dementia. The 
      advantages and disadvantages of electronic surveillance in LTC research and the
      ethical principles involved are discussed, and an argument is developed for using
      electronic surveillance in both the shared, as well as private, spaces of the
      facility.
CI  - Copyright 2010, SLACK Incorporated.
FAU - Sifford, K Susan
AU  - Sifford KS
AD  - State University, School of Nursing, PO Box 910, State University (Jonesboro), AR
      72467, USA. ksifford@astate.edu
FAU - Bharucha, Ashok
AU  - Bharucha A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100127
PL  - United States
TA  - Res Gerontol Nurs
JT  - Research in gerontological nursing
JID - 101392499
SB  - IM
MH  - Aged
MH  - Confidentiality
MH  - Data Collection/ethics/legislation & jurisprudence/*methods
MH  - Dementia/*complications/psychology
MH  - Elder Abuse/ethics/legislation & jurisprudence/*statistics & numerical data
MH  - Electronics
MH  - Human Experimentation/ethics/legislation & jurisprudence
MH  - Humans
MH  - Interpersonal Relations
MH  - *Nursing Homes/organization & administration
MH  - Nursing Research/ethics/legislation & jurisprudence/*methods
MH  - Prevalence
MH  - Principle-Based Ethics
MH  - Risk Reduction Behavior
MH  - Safety Management
MH  - Technology Assessment, Biomedical
MH  - United States/epidemiology
MH  - Videotape Recording/ethics/legislation & jurisprudence/*methods
MH  - Vulnerable Populations
EDAT- 2010/02/05 06:00
MHDA- 2010/03/12 06:00
CRDT- 2010/02/05 06:00
PHST- 2008/11/20 00:00 [received]
PHST- 2009/03/26 00:00 [accepted]
PHST- 2010/02/05 06:00 [entrez]
PHST- 2010/02/05 06:00 [pubmed]
PHST- 2010/03/12 06:00 [medline]
AID - 10.3928/19404921-20090706-01 [doi]
PST - ppublish
SO  - Res Gerontol Nurs. 2010 Jan;3(1):5-10. doi: 10.3928/19404921-20090706-01. Epub
      2010 Jan 27.


PMID- 20128522
OWN - NLM
STAT- MEDLINE
DCOM- 20100319
LR  - 20100224
IS  - 0279-3695 (Print)
IS  - 0279-3695 (Linking)
VI  - 48
IP  - 2
DP  - 2010 Feb
TI  - Research with the doubly vulnerable population of individuals who abuse alcohol: 
      an ethical dilemma.
PG  - 38-43
LID - 10.3928/02793695-20100108-01 [doi]
AB  - Individuals who have maladaptive patterns of drinking alcohol fall into the
      category of vulnerable research participants for many reasons, not the least of
      which includes the stigma often placed on individuals who abuse alcohol.
      Vulnerable subgroups within the population of people who abuse alcohol include
      women; older adults; incarcerated, socioeconomically disadvantaged, and mentally 
      ill individuals; as well as people from racial minorities. Thus, as research
      participants, individuals who abuse alcohol can be labeled a doubly vulnerable
      population. Belonging to more than one population simultaneously can lead to a
      compromised ability to protect one's own interests or greater susceptibility to
      harm related to participation in research studies. Arguments against including
      people who abuse alcohol as research participants will be presented, followed by 
      the argument for including theses individuals, which is suggested as the more
      ethically sound of the two points of view.
FAU - Gwyn, Priscilla Gage
AU  - Gwyn PG
AD  - Department of Nursing, Florida Hospital College of Health Sciences, Orlando, FL
      32803, USA. gage.gwyn@fhchs.edu
FAU - Colin, Jessie M
AU  - Colin JM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Psychosoc Nurs Ment Health Serv
JT  - Journal of psychosocial nursing and mental health services
JID - 8200911
SB  - IM
MH  - Aged
MH  - *Alcoholism/complications
MH  - Diagnosis, Dual (Psychiatry)
MH  - Dissent and Disputes
MH  - *Ethics, Research
MH  - Guidelines as Topic
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - *Mental Disorders/complications
MH  - Minority Groups
MH  - Patient Advocacy/*ethics
MH  - Prejudice
MH  - Prisoners
MH  - Psychiatric Nursing/ethics
MH  - Stereotyping
MH  - *Vulnerable Populations
EDAT- 2010/02/05 06:00
MHDA- 2010/03/20 06:00
CRDT- 2010/02/05 06:00
PHST- 2009/03/22 00:00 [received]
PHST- 2009/10/05 00:00 [accepted]
PHST- 2010/02/05 06:00 [entrez]
PHST- 2010/02/05 06:00 [pubmed]
PHST- 2010/03/20 06:00 [medline]
AID - 10.3928/02793695-20100108-01 [doi]
PST - ppublish
SO  - J Psychosoc Nurs Ment Health Serv. 2010 Feb;48(2):38-43. doi:
      10.3928/02793695-20100108-01.


PMID- 20127058
OWN - NLM
STAT- MEDLINE
DCOM- 20100517
LR  - 20211020
IS  - 1432-055X (Electronic)
IS  - 0003-2417 (Linking)
VI  - 59
IP  - 2
DP  - 2010 Feb
TI  - [EEG-adjusted target-controlled infusion : Propofol target concentration with
      different doses of remifentanil].
PG  - 126-34
LID - 10.1007/s00101-009-1666-1 [doi]
AB  - BACKGROUND: The aim of this study was to examine to what extent the use of
      electroencephalography (EEG) monitoring leads to an adaptation of the
      target-controlled infusion (TCI) concentration of propofol during propofol
      anaesthesia with different doses of remifentanil. PATIENTS AND METHODS: With
      ethics committee approval 60 patients (27-69 years old) with American Society of 
      Anesthesiologists classification (ASA) I-III received anaesthestics with propofol
      (TCI, Diprifusor, AstraZeneca, Wedel, Deutschland) and 0.2, 0.4, or 0.6 microg/kg
      body weight remifentanil, respectively (groups 1-3). Anaesthesia was maintained
      at a level of deep hypnosis (EEG stages D(2)/E(0), EEG monitor: Narcotrend,
      version 2.0/5.0, manufacturer: MT MonitorTechnik, Bad Bramstedt, Germany).
      RESULTS: During the steady state the propofol concentration in groups 1-3 was
      3.02+/-0.86, 1.93+/-0.53 and 1.60+/-0.55 microg/ml, respectively (p<0.001). Women
      had a higher propofol consumption than men (p<0.05). Dreams during anaesthesia
      were more often reported by women than by men (p<0.05). The need for
      postoperative analgesia decreased with an increasing intraoperative remifentanil 
      dose (p<0.05). CONCLUSIONS: The study demonstrates that remifentanil has both
      analgetic and hypnotic effects. With increasing remifentanil dose the propofol
      requirement decreased and in this context EEG monitoring is useful to adapt the
      target concentrations of propofol to the patients' age and gender.
FAU - Buttner, N
AU  - Buttner N
AD  - Arbeitsgruppe Informatik/Biometrie der Anasthesie, Klinikum Region Hannover
      Oststadt-Heidehaus, Medizinische Hochschule Hannover, Deutschland.
FAU - Schultz, B
AU  - Schultz B
FAU - Grouven, U
AU  - Grouven U
FAU - Schultz, A
AU  - Schultz A
LA  - ger
PT  - Journal Article
PT  - Randomized Controlled Trial
TT  - EEG-adaptierte "target-controlled infusion" : Propofolzielkonzentration bei
      unterschiedlichen Remifentanildosierungen.
PL  - Germany
TA  - Anaesthesist
JT  - Der Anaesthesist
JID - 0370525
RN  - 0 (Anesthetics, Intravenous)
RN  - 0 (Piperidines)
RN  - P10582JYYK (Remifentanil)
RN  - YI7VU623SF (Propofol)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aging/physiology
MH  - Anesthesia Recovery Period
MH  - *Anesthesia, Intravenous
MH  - Anesthetics, Intravenous/*administration & dosage
MH  - Blood Pressure/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Double-Blind Method
MH  - Dreams/drug effects
MH  - Electroencephalography/*drug effects
MH  - Female
MH  - Heart Rate/drug effects
MH  - Humans
MH  - Infusions, Intravenous
MH  - Male
MH  - Middle Aged
MH  - Monitoring, Intraoperative
MH  - Pain, Postoperative/drug therapy
MH  - Piperidines/*administration & dosage
MH  - Propofol/*administration & dosage
MH  - Prospective Studies
MH  - Remifentanil
MH  - Sex Characteristics
EDAT- 2010/02/04 06:00
MHDA- 2010/05/18 06:00
CRDT- 2010/02/04 06:00
PHST- 2010/02/04 06:00 [entrez]
PHST- 2010/02/04 06:00 [pubmed]
PHST- 2010/05/18 06:00 [medline]
AID - 10.1007/s00101-009-1666-1 [doi]
PST - ppublish
SO  - Anaesthesist. 2010 Feb;59(2):126-34. doi: 10.1007/s00101-009-1666-1.


PMID- 20127056
OWN - NLM
STAT- MEDLINE
DCOM- 20100517
LR  - 20131106
IS  - 1432-055X (Electronic)
IS  - 0003-2417 (Linking)
VI  - 59
IP  - 2
DP  - 2010 Feb
TI  - [Perimortem semen retrieval from comatose intensive care patients : Medico-legal,
      psychological and ethical aspects].
PG  - 144-8
LID - 10.1007/s00101-010-1676-z [doi]
AB  - DEFINITION OF THE PROBLEM: Due to new technological advances in assisted
      reproduction, perimortem sperm retrieval has developed into a subject of
      increasing interest for families of comatose or dying male patients in critical
      care facilities. These requests raise a number of medical, ethical, legal and
      psychological issues. ARGUMENTS AND CONCLUSIONS: The case of a comatose dying
      male patient is used to illustrate the variety of positions and problems which
      have to be discussed. The importance of written consent of the donor, the
      interest of the unborn child and the legal limitations are highlighted.
FAU - Schmitz, D
AU  - Schmitz D
AD  - Klinik fur Anasthesiologie und Operative Intensivmedizin, Universitatsmedizin
      Mannheim, Deutschland. Dr.D.Schmitz@web.de
FAU - Schmitz, J
AU  - Schmitz J
FAU - Guski, R
AU  - Guski R
FAU - Kalenka, A
AU  - Kalenka A
LA  - ger
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - Perimortale Spermienentnahme bei komatosen Intensivpatienten : Medikolegale,
      psychologische und ethische Aspekte.
PL  - Germany
TA  - Anaesthesist
JT  - Der Anaesthesist
JID - 0370525
SB  - IM
MH  - Adult
MH  - Child
MH  - Coma
MH  - Critical Care
MH  - Death
MH  - Human Rights
MH  - Humans
MH  - Informed Consent
MH  - Male
MH  - Personal Autonomy
MH  - Reproductive Techniques, Assisted/ethics/legislation & jurisprudence/psychology
MH  - Sperm Retrieval/*ethics/*legislation & jurisprudence/psychology
EDAT- 2010/02/04 06:00
MHDA- 2010/05/18 06:00
CRDT- 2010/02/04 06:00
PHST- 2010/02/04 06:00 [entrez]
PHST- 2010/02/04 06:00 [pubmed]
PHST- 2010/05/18 06:00 [medline]
AID - 10.1007/s00101-010-1676-z [doi]
PST - ppublish
SO  - Anaesthesist. 2010 Feb;59(2):144-8. doi: 10.1007/s00101-010-1676-z.


PMID- 20126639
OWN - NLM
STAT- MEDLINE
DCOM- 20100930
LR  - 20220331
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 5
IP  - 2
DP  - 2010 Feb 1
TI  - Persistent donor cell gene expression among human induced pluripotent stem cells 
      contributes to differences with human embryonic stem cells.
PG  - e8975
LID - 10.1371/journal.pone.0008975 [doi]
AB  - Human induced pluripotent stem cells (hiPSCs) generated by de-differentiation of 
      adult somatic cells offer potential solutions for the ethical issues surrounding 
      human embryonic stem cells (hESCs), as well as their immunologic rejection after 
      cellular transplantation. However, although hiPSCs have been described as
      "embryonic stem cell-like", these cells have a distinct gene expression pattern
      compared to hESCs, making incomplete reprogramming a potential pitfall. It is
      unclear to what degree the difference in tissue of origin may contribute to these
      gene expression differences. To answer these important questions, a careful
      transcriptional profiling analysis is necessary to investigate the exact
      reprogramming state of hiPSCs, as well as analysis of the impression, if any, of 
      the tissue of origin on the resulting hiPSCs. In this study, we compare the gene 
      profiles of hiPSCs derived from fetal fibroblasts, neonatal fibroblasts, adipose 
      stem cells, and keratinocytes to their corresponding donor cells and hESCs. Our
      analysis elucidates the overall degree of reprogramming within each hiPSC line,
      as well as the "distance" between each hiPSC line and its donor cell. We further 
      identify genes that have a similar mode of regulation in hiPSCs and their
      corresponding donor cells compared to hESCs, allowing us to specify core sets of 
      donor genes that continue to be expressed in each hiPSC line. We report that
      residual gene expression of the donor cell type contributes significantly to the 
      differences among hiPSCs and hESCs, and adds to the incompleteness in
      reprogramming. Specifically, our analysis reveals that fetal fibroblast-derived
      hiPSCs are closer to hESCs, followed by adipose, neonatal fibroblast, and
      keratinocyte-derived hiPSCs.
FAU - Ghosh, Zhumur
AU  - Ghosh Z
AD  - Department of Medicine, Stanford University School of Medicine, Stanford,
      California, United States of America.
FAU - Wilson, Kitchener D
AU  - Wilson KD
FAU - Wu, Yi
AU  - Wu Y
FAU - Hu, Shijun
AU  - Hu S
FAU - Quertermous, Thomas
AU  - Quertermous T
FAU - Wu, Joseph C
AU  - Wu JC
LA  - eng
GR  - R01 AI085575-01/AI/NIAID NIH HHS/United States
GR  - R01 AI085575/AI/NIAID NIH HHS/United States
GR  - R01AI085575/AI/NIAID NIH HHS/United States
GR  - DP2 OD004437/OD/NIH HHS/United States
GR  - DP2 OD004437-01/OD/NIH HHS/United States
GR  - DP2OD004437/OD/NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20100201
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adipose Tissue/cytology/metabolism
MH  - Cell Differentiation/genetics
MH  - Cell Line
MH  - Cell Lineage/*genetics
MH  - Cells, Cultured
MH  - Cluster Analysis
MH  - Embryonic Stem Cells/cytology/*metabolism
MH  - Fetus
MH  - Fibroblasts/cytology/metabolism
MH  - *Gene Expression Profiling
MH  - Humans
MH  - Induced Pluripotent Stem Cells/cytology/*metabolism
MH  - Infant, Newborn
MH  - Keratinocytes/cytology/metabolism
MH  - Oligonucleotide Array Sequence Analysis/methods
MH  - Stem Cells/cytology/metabolism
PMC - PMC2813859
EDAT- 2010/02/04 06:00
MHDA- 2010/10/01 06:00
CRDT- 2010/02/04 06:00
PHST- 2009/10/23 00:00 [received]
PHST- 2009/12/27 00:00 [accepted]
PHST- 2010/02/04 06:00 [entrez]
PHST- 2010/02/04 06:00 [pubmed]
PHST- 2010/10/01 06:00 [medline]
AID - 10.1371/journal.pone.0008975 [doi]
PST - epublish
SO  - PLoS One. 2010 Feb 1;5(2):e8975. doi: 10.1371/journal.pone.0008975.


PMID- 20125174
OWN - NLM
STAT- MEDLINE
DCOM- 20100430
LR  - 20211020
IS  - 1759-4804 (Electronic)
IS  - 1759-4790 (Linking)
VI  - 6
IP  - 2
DP  - 2010 Feb
TI  - Disease modification in ankylosing spondylitis.
PG  - 75-81
LID - 10.1038/nrrheum.2009.258 [doi]
AB  - The concept of disease modification in ankylosing spondylitis (AS) incorporates
      aspects of inflammation, bone destruction and new bone formation. The degree to
      which inflammation and new bone formation are linked remains conjectural, but
      data from MRI studies of spinal inflammation support the concept of such
      coupling; however, these studies also suggest a role for the involvement of
      noninflammatory pathways, such as those involving bone morphogenetic proteins,
      wingless proteins and Dickkopf-1, in the formation of new bone. The main clinical
      outcome that reflects disease modification is the modified Stoke Ankylosing
      Spondylitis Spine Score, which assesses abnormalities in the anterior vertebral
      corners of the cervical and lumbar spine. However, radiographic progression can
      only be reliably detected using this method after at least 2 years, and this
      delay precludes the conduct of placebo-controlled trials on ethical grounds.
      Preliminary data using this scoring tool suggest that cyclooxygenase-2-selective 
      NSAIDs might reduce disease progression if used continuously over 2 years. By
      contrast, three different anti-tumor necrosis factor therapies have shown no
      impact on radiographic progression. Therapeutic trials recruiting patients early 
      in their disease course and at high risk of radiographic progression constitute a
      high priority for clinical research in AS.
FAU - Maksymowych, Walter P
AU  - Maksymowych WP
AD  - Department of Medicine, 562 Heritage Medical Research Building, University of
      Alberta, Edmonton, Alberta, Canada. walter.maksymowych@ualberta.ca
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Nat Rev Rheumatol
JT  - Nature reviews. Rheumatology
JID - 101500080
RN  - 0 (Cyclooxygenase 2 Inhibitors)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Cyclooxygenase 2 Inhibitors/therapeutic use
MH  - Humans
MH  - Radiography
MH  - Spondylitis, Ankylosing/diagnostic imaging/drug therapy/*physiopathology
MH  - Tumor Necrosis Factor-alpha/antagonists & inhibitors
RF  - 61
EDAT- 2010/02/04 06:00
MHDA- 2010/05/01 06:00
CRDT- 2010/02/04 06:00
PHST- 2010/02/04 06:00 [entrez]
PHST- 2010/02/04 06:00 [pubmed]
PHST- 2010/05/01 06:00 [medline]
AID - nrrheum.2009.258 [pii]
AID - 10.1038/nrrheum.2009.258 [doi]
PST - ppublish
SO  - Nat Rev Rheumatol. 2010 Feb;6(2):75-81. doi: 10.1038/nrrheum.2009.258.


PMID- 20125171
OWN - NLM
STAT- MEDLINE
DCOM- 20100430
LR  - 20211020
IS  - 1759-4804 (Electronic)
IS  - 1759-4790 (Linking)
VI  - 6
IP  - 2
DP  - 2010 Feb
TI  - Ethics: Investigators' interests: what should trial participants be told?
PG  - 70-1
LID - 10.1038/nrrheum.2009.264 [doi]
AB  - Minimizing the potential adverse effects of clinical investigators' financial
      conflicts of interest involves, in part, determining how much of an
      investigator's "business" should be disclosed to participants in research
      studies. What should be disclosed and why? How will we know if disclosure
      matters?
FAU - Romain, Paul L
AU  - Romain PL
AD  - Division of Rheumatology, Beth Israel Deaconess Medical Center, 330 Brookline
      Avenue, Boston, MA 02215, USA. promain@bidmc.harvard.edu
LA  - eng
PT  - News
PL  - United States
TA  - Nat Rev Rheumatol
JT  - Nature reviews. Rheumatology
JID - 101500080
SB  - IM
MH  - Biomedical Research/ethics
MH  - Clinical Trials as Topic/*ethics
MH  - *Conflict of Interest
MH  - *Disclosure
MH  - Humans
EDAT- 2010/02/04 06:00
MHDA- 2010/05/01 06:00
CRDT- 2010/02/04 06:00
PHST- 2010/02/04 06:00 [entrez]
PHST- 2010/02/04 06:00 [pubmed]
PHST- 2010/05/01 06:00 [medline]
AID - nrrheum.2009.264 [pii]
AID - 10.1038/nrrheum.2009.264 [doi]
PST - ppublish
SO  - Nat Rev Rheumatol. 2010 Feb;6(2):70-1. doi: 10.1038/nrrheum.2009.264.


PMID- 20125014
OWN - NLM
STAT- MEDLINE
DCOM- 20100720
LR  - 20100310
IS  - 1473-656X (Electronic)
IS  - 1040-872X (Linking)
VI  - 22
IP  - 2
DP  - 2010 Apr
TI  - Ethical considerations in first-trimester Down syndrome risk assessment.
PG  - 135-8
LID - 10.1097/GCO.0b013e3283374a9f [doi]
AB  - PURPOSE OF REVIEW: First-trimester risk assessment has now become sophisticated
      and of increasing relevance and applicability to decision-making by pregnant
      woman about invasive diagnosis. Ethics is an essential dimension of understanding
      this relevance and applicability. This paper addresses the ethical dimensions of 
      first-trimester risk assessment for trisomy 21. RECENT FINDINGS: It is now well
      established in the ethics and law of the informed consent process that physicians
      are obligated to offer to patients all medically reasonable alternatives for
      managing the patient's condition. This disclosure should be guided by the
      reasonable person standard: the physician should provide clinically important
      information about the patient's condition or diagnosis, the medically reasonable 
      alternatives for managing it, and the clinical benefits and risks of each such
      alternative. SUMMARY: On the basis of the ethics of informed consent, we argue
      that routinely offering first-trimester risk assessment in centers qualified to
      provide it is ethically obligatory. We describe how pregnant women can be
      expected to respond to this offer. We then argue that routinely withholding the
      results of first-trimester risk assessment is ethically unjustified. The ethics
      of informed consent is an essential dimension of first-trimester risk assessment 
      for trisomy 21.
FAU - Chervenak, Frank A
AU  - Chervenak FA
AD  - Department of Obstetrics and Gynecology, Weill Medical College of Cornell
      University, New York, New York, USA. fac2001@med.cornell.edu
FAU - McCullough, Laurence B
AU  - McCullough LB
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Curr Opin Obstet Gynecol
JT  - Current opinion in obstetrics & gynecology
JID - 9007264
SB  - IM
MH  - Down Syndrome/*diagnosis
MH  - Female
MH  - Humans
MH  - Maternal Age
MH  - Patient Education as Topic
MH  - Patient Participation
MH  - Physician-Patient Relations
MH  - Pregnancy
MH  - *Pregnancy Trimester, First
MH  - Prenatal Diagnosis/*ethics/methods
MH  - Risk Assessment
RF  - 26
EDAT- 2010/02/04 06:00
MHDA- 2010/07/21 06:00
CRDT- 2010/02/04 06:00
PHST- 2010/02/04 06:00 [entrez]
PHST- 2010/02/04 06:00 [pubmed]
PHST- 2010/07/21 06:00 [medline]
AID - 10.1097/GCO.0b013e3283374a9f [doi]
PST - ppublish
SO  - Curr Opin Obstet Gynecol. 2010 Apr;22(2):135-8. doi:
      10.1097/GCO.0b013e3283374a9f.


PMID- 20124893
OWN - NLM
STAT- MEDLINE
DCOM- 20100712
LR  - 20100420
IS  - 1473-6500 (Electronic)
IS  - 0952-7907 (Linking)
VI  - 23
IP  - 2
DP  - 2010 Apr
TI  - Palliative care and involvement of anaesthesiology: current discussions.
PG  - 173-6
LID - 10.1097/ACO.0b013e328337331d [doi]
AB  - PURPOSE OF REVIEW: To summarize various developments related to palliative care, 
      especially related to ethical issues. To emphasize the involvement of
      anaesthesiology in palliative care. RECENT FINDINGS: Euthanasia has been
      legalized in Belgium, the Netherlands and Luxemburg (BENELUX countries). A group 
      from Belgium has now proposed using euthanasia in patients in whom palliative
      care has been deemed 'futile'. This practice of so-called 'integral palliative
      care' is strongly rejected in a study from Germany. Palliative sedation is an
      ethically different approach with no intention to kill the patient. The European 
      Association of Palliative Care has proposed a framework for individual guidelines
      for palliative sedation. The important role of anaesthesiology in palliative care
      teams is emphasized. SUMMARY: Palliative care is a powerful approach to patient
      care during terminal illness, emphasizing quality of life even if it may shorten 
      the length of life. Traditionally, palliative care has been contrasted with
      active euthanasia, but a group from Belgium has challenged this concept recently,
      advocating the use of euthanasia in circumstances in which palliative care has
      become 'futile'. This new approach led to strong reactions by a group from
      Germany, stressing that killing on demand in palliative care should under no
      circumstances be justified. In contrast, palliative sedation is a common method
      in special cases to reduce intractable symptoms. A new framework for palliative
      sedation produced by the European Association of Palliative Care may encourage
      institutions to set up their own palliative sedation guidelines. Worldwide,
      anaesthesiologists have a significant role in palliative care due to their unique
      complex expertise mainly in pain therapy and including transient sedation of
      patients.
FAU - Kettler, Dietrich
AU  - Kettler D
AD  - Division of Palliative Medicine, Centre of Anaesthesiology, Emergency and
      Intensive Care Medicine, Georg-August-University Goettingen, Goettingen, Germany.
      dkettle@gwdg.de
FAU - Nauck, Friedemann
AU  - Nauck F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Curr Opin Anaesthesiol
JT  - Current opinion in anaesthesiology
JID - 8813436
SB  - IM
MH  - Anesthesia
MH  - Anesthesiology/*trends
MH  - Conscious Sedation
MH  - Euthanasia/legislation & jurisprudence/trends
MH  - Humans
MH  - Palliative Care/*trends
RF  - 19
EDAT- 2010/02/04 06:00
MHDA- 2010/07/14 06:00
CRDT- 2010/02/04 06:00
PHST- 2010/02/04 06:00 [entrez]
PHST- 2010/02/04 06:00 [pubmed]
PHST- 2010/07/14 06:00 [medline]
AID - 10.1097/ACO.0b013e328337331d [doi]
PST - ppublish
SO  - Curr Opin Anaesthesiol. 2010 Apr;23(2):173-6. doi: 10.1097/ACO.0b013e328337331d.


PMID- 20124892
OWN - NLM
STAT- MEDLINE
DCOM- 20100315
LR  - 20100727
IS  - 1530-0293 (Electronic)
IS  - 0090-3493 (Linking)
VI  - 38
IP  - 3
DP  - 2010 Mar
TI  - The circulatory-respiratory determination of death in organ donation.
PG  - 963-70
LID - 10.1097/CCM.0b013e3181c58916 [doi]
AB  - OBJECTIVE: Death statutes permit physicians to declare death on the basis of
      irreversible cessation of circulatory-respiratory or brain functions. The growing
      practice of organ donation after circulatory determination of death now requires 
      physicians to exercise greater specificity in circulatory-respiratory death
      determination. We studied circulatory-respiratory death determination to clarify 
      its concept, practice, and application to innovative circulatory determination of
      death protocols. RESULTS: It is ethically and legally appropriate to procure
      organs when permanent cessation (will not return) of circulation and respiration 
      has occurred but before irreversible cessation (cannot return) has occurred
      because permanent cessation: 1) is an established medical practice standard for
      determining death; 2) is the meaning of "irreversible" in the Uniform
      Determination of Death Act; and 3) does not violate the "Dead Donor Rule."
      CONCLUSIONS: The use of unmodified extracorporeal membrane oxygenation in the
      circulatory determination of death donor after death is declared should be
      abandoned because, by restoring brain circulation, it retroactively negates the
      previous death determination. Modifications of extracorporeal membrane
      oxygenation that avoid this problem by excluding brain circulation are contrived,
      invasive, and, if used, should require consent of surrogates. Heart donation in
      circulatory determination of death is acceptable if proper standards are followed
      to declare donor death after establishing the permanent cessation of circulation.
      Pending additional data on "auto-resuscitation," we recommend that all
      circulatory determination of death programs should utilize the prevailing
      standard of 2 to 5 mins of demonstrated mechanical asystole before declaring
      death.
FAU - Bernat, James L
AU  - Bernat JL
AD  - Neurology Department, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
      bernat@dartmouth.edu
FAU - Capron, Alexander M
AU  - Capron AM
FAU - Bleck, Thomas P
AU  - Bleck TP
FAU - Blosser, Sandralee
AU  - Blosser S
FAU - Bratton, Susan L
AU  - Bratton SL
FAU - Childress, James F
AU  - Childress JF
FAU - DeVita, Michael A
AU  - DeVita MA
FAU - Fulda, Gerard J
AU  - Fulda GJ
FAU - Gries, Cynthia J
AU  - Gries CJ
FAU - Mathur, Mudit
AU  - Mathur M
FAU - Nakagawa, Thomas A
AU  - Nakagawa TA
FAU - Rushton, Cynda Hylton
AU  - Rushton CH
FAU - Shemie, Sam D
AU  - Shemie SD
FAU - White, Douglas B
AU  - White DB
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Crit Care Med
JT  - Critical care medicine
JID - 0355501
SB  - IM
CIN - Crit Care Med. 2010 Mar;38(3):1011-2. PMID: 20168173
CIN - Crit Care Med. 2010 Jun;38(6):1498-9; author reply 1499. PMID: 20502147
CIN - Crit Care Med. 2010 Aug;38(8):1761; author reply 1761-2. PMID: 20647819
MH  - Brain Death/legislation & jurisprudence
MH  - *Death
MH  - *Ethics, Medical
MH  - Extracorporeal Membrane Oxygenation
MH  - Heart Arrest/*diagnosis
MH  - Heart Transplantation/*ethics/legislation & jurisprudence
MH  - Humans
MH  - Tissue and Organ Procurement/*ethics/legislation & jurisprudence
MH  - United States
EDAT- 2010/02/04 06:00
MHDA- 2010/03/17 06:00
CRDT- 2010/02/04 06:00
PHST- 2010/02/04 06:00 [entrez]
PHST- 2010/02/04 06:00 [pubmed]
PHST- 2010/03/17 06:00 [medline]
AID - 10.1097/CCM.0b013e3181c58916 [doi]
PST - ppublish
SO  - Crit Care Med. 2010 Mar;38(3):963-70. doi: 10.1097/CCM.0b013e3181c58916.


PMID- 20124277
OWN - NLM
STAT- MEDLINE
DCOM- 20100426
LR  - 20161020
IS  - 1526-3347 (Electronic)
IS  - 0191-9601 (Linking)
VI  - 31
IP  - 2
DP  - 2010 Feb
TI  - Ethics for the pediatrician: imperiled newborns: limiting treatment.
PG  - 72-5
LID - 10.1542/pir.31-2-72 [doi]
FAU - Mercurio, Mark R
AU  - Mercurio MR
AD  - Yale University School of Medicine, Department of Pediatrics, New Haven, CT, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Pediatr Rev
JT  - Pediatrics in review
JID - 8103046
SB  - IM
MH  - Disabled Children
MH  - *Ethics, Professional
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Neonatology/ethics
MH  - Pediatrics/*ethics
MH  - Physician-Patient Relations
MH  - Withholding Treatment
RF  - 10
EDAT- 2010/02/04 06:00
MHDA- 2010/04/27 06:00
CRDT- 2010/02/04 06:00
PHST- 2010/02/04 06:00 [entrez]
PHST- 2010/02/04 06:00 [pubmed]
PHST- 2010/04/27 06:00 [medline]
AID - 31/2/72 [pii]
AID - 10.1542/pir.31-2-72 [doi]
PST - ppublish
SO  - Pediatr Rev. 2010 Feb;31(2):72-5. doi: 10.1542/pir.31-2-72.


PMID- 20124254
OWN - NLM
STAT- MEDLINE
DCOM- 20100614
LR  - 20100203
IS  - 1938-2715 (Electronic)
IS  - 1049-9091 (Linking)
VI  - 27
IP  - 1
DP  - 2010 Feb
TI  - Unlocking the closed door: arguments for open access hospice.
PG  - 86-90
LID - 10.1177/1049909109338388 [doi]
AB  - The traditional view of standard hospice (SH) care is that once begun, the
      doorway toward curative and other forms of nonpalliative treatment is irrevocably
      locked. We will argue that such a traditional view needs to be reassessed in
      light of new arguments and data regarding access to these avenues of treatment.
      We will argue that patients should be supported in their transition from SH to
      open access hospice (OAH). Open access hospice should be available to all
      patients because of ethical arguments, patient satisfaction arguments, and costs 
      of care arguments. More randomized controlled research trials need to be
      performed to study the impact of OAH versus SH. This research should focus on
      patient satisfaction, cost, and survival.
FAU - Furman, Christian Davis
AU  - Furman CD
AD  - University of Louisville School of Medicine, Louisville, Kentucky 40202, USA.
      cdfurm02@louisville.edu
FAU - Doukas, David John
AU  - Doukas DJ
FAU - Reichel, William
AU  - Reichel W
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Hosp Palliat Care
JT  - The American journal of hospice & palliative care
JID - 9008229
SB  - IM
MH  - *Health Services Accessibility/economics/ethics/legislation & jurisprudence
MH  - Hospice Care/ethics/*organization & administration
MH  - Humans
MH  - Medicare
MH  - Models, Theoretical
MH  - United States
EDAT- 2010/02/04 06:00
MHDA- 2010/06/15 06:00
CRDT- 2010/02/04 06:00
PHST- 2010/02/04 06:00 [entrez]
PHST- 2010/02/04 06:00 [pubmed]
PHST- 2010/06/15 06:00 [medline]
AID - 1049909109338388 [pii]
AID - 10.1177/1049909109338388 [doi]
PST - ppublish
SO  - Am J Hosp Palliat Care. 2010 Feb;27(1):86-90. doi: 10.1177/1049909109338388.


PMID- 20124172
OWN - NLM
STAT- MEDLINE
DCOM- 20100325
LR  - 20220409
IS  - 1527-7755 (Electronic)
IS  - 0732-183X (Linking)
VI  - 28
IP  - 7
DP  - 2010 Mar 1
TI  - End-of-life discussions, goal attainment, and distress at the end of life:
      predictors and outcomes of receipt of care consistent with preferences.
PG  - 1203-8
LID - 10.1200/JCO.2009.25.4672 [doi]
AB  - PURPOSE: Physicians have an ethical obligation to honor patients' values for
      care, including at the end of life (EOL). We sought to evaluate factors that help
      patients to receive care consistent with their preferences. METHODS: This was a
      longitudinal multi-institutional cohort study. We measured baseline preferences
      for life-extending versus symptom-directed care and actual EOL care received in
      325 patients with advanced cancer. We also measured associated sociodemographic, 
      health, and communication characteristics, including EOL discussions between
      patients and physicians. RESULTS: Preferences were assessed a median of 125 days 
      before death. Overall, 68% of patients (220 of 325 patients) received EOL care
      consistent with baseline preferences. The proportion was slightly higher among
      patients who recognized they were terminally ill (74%, 90 of 121 patients; P =
      .05). Patients who recognized their terminal illness were more likely to prefer
      symptom-directed care (83%, 100 of 121 patients; v 66%, 127 of 191 patients; P = 
      .003). However, some patients who were aware they were terminally ill wished to
      receive life-extending care (17%, 21 of 121 patients). Patients who reported
      having discussed their wishes for EOL care with a physician (39%, 125 of 322
      patients) were more likely to receive care that was consistent with their
      preferences, both in the full sample (odds ratio [OR] = 2.26; P < .0001) and
      among patients who were aware they were terminally ill (OR = 3.94; P = .0005).
      Among patients who received no life-extending measures, physical distress was
      lower (mean score, 3.1 v 4.1; P = .03) among patients for whom such care was
      consistent with preferences. CONCLUSION: Patients with cancer are more likely to 
      receive EOL care that is consistent with their preferences when they have had the
      opportunity to discuss their wishes for EOL care with a physician.
FAU - Mack, Jennifer W
AU  - Mack JW
AD  - Dana-Farber Cancer Institute, Department of Pediatric Oncology, 44 Binney St-454,
      Boston, MA 02115, USA. jennifer_mack@dfci.harvard.edu
FAU - Weeks, Jane C
AU  - Weeks JC
FAU - Wright, Alexi A
AU  - Wright AA
FAU - Block, Susan D
AU  - Block SD
FAU - Prigerson, Holly G
AU  - Prigerson HG
LA  - eng
GR  - R01 CA106370/CA/NCI NIH HHS/United States
GR  - R01 MH063892/MH/NIMH NIH HHS/United States
GR  - MH63892/MH/NIMH NIH HHS/United States
GR  - CA106370/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20100201
PL  - United States
TA  - J Clin Oncol
JT  - Journal of clinical oncology : official journal of the American Society of
      Clinical Oncology
JID - 8309333
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - *Patient Preference
MH  - *Physician-Patient Relations
MH  - Quality of Life
MH  - *Terminal Care
MH  - Terminally Ill/*psychology
PMC - PMC2834470
EDAT- 2010/02/04 06:00
MHDA- 2010/03/26 06:00
CRDT- 2010/02/04 06:00
PHST- 2010/02/04 06:00 [entrez]
PHST- 2010/02/04 06:00 [pubmed]
PHST- 2010/03/26 06:00 [medline]
AID - JCO.2009.25.4672 [pii]
AID - 10.1200/JCO.2009.25.4672 [doi]
PST - ppublish
SO  - J Clin Oncol. 2010 Mar 1;28(7):1203-8. doi: 10.1200/JCO.2009.25.4672. Epub 2010
      Feb 1.


PMID- 20123945
OWN - NLM
STAT- MEDLINE
DCOM- 20100604
LR  - 20191210
IS  - 1477-030X (Electronic)
IS  - 0269-2163 (Linking)
VI  - 24
IP  - 3
DP  - 2010 Apr
TI  - Undergraduate training in palliative medicine: is more necessarily better?
PG  - 306-9
LID - 10.1177/0269216309351867 [doi]
AB  - The General Medical Council's call to modernize medical education prompted the
      University of Liverpool Medical School to develop a new undergraduate programme, 
      integrating palliative medicine as 'core' curricula. Following successful
      piloting, the palliative medicine training programme was further developed and
      expanded. This paper examines whether the additional investment produces improved
      outcomes. In 1999, fourth year undergraduate medical students (Cohort 1, n = 217)
      undertook a 2-week pilot education programme in palliative medicine.
      Subsequently, the training programme was refined and extended, incorporating
      advanced communication skills training, an ethics project and individual case
      presentations (Cohort 2, n = 443). Congruent with the study's theoretical driver 
      of self-efficacy, both cohorts were surveyed pre- and post-programme with
      validated measures of: (i) self-efficacy in palliative care scale; (ii)
      thanatophobia scale. No significant differences between cohorts' pre-programme
      scores were identified. Within each cohort, statistically and educationally
      significant post-education improvements were recorded in both scales. Further
      post-education analysis indicated that the extended programme produces
      significantly greater improvements in all domains of the self-efficacy in
      palliative care scale (communication, t =-7.28, patient management, t =-5.96,
      multidisciplinary team-working t =-3.77 at p < 0.000), but not thanatophobia.
      Although improvements were recorded in both cohorts, participation in the
      extended education programme resulted in further statistically significant gains.
      Interpreted through the theoretical model employed, improved self-efficacy and
      outcome expectancies will result in behavioural change that leads to improved
      practice and better patient care.
FAU - Mason, Stephen R
AU  - Mason SR
AD  - Marie Curie Palliative Care Institute Liverpool, UK. stephen.mason@liv.ac.uk
FAU - Ellershaw, John E
AU  - Ellershaw JE
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100201
PL  - England
TA  - Palliat Med
JT  - Palliative medicine
JID - 8704926
SB  - IM
MH  - Curriculum
MH  - Education, Medical, Undergraduate/methods/*standards
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Male
MH  - Models, Educational
MH  - *Palliative Care
MH  - *Program Development
MH  - Program Evaluation
MH  - Self Efficacy
MH  - Students, Medical/psychology
EDAT- 2010/02/04 06:00
MHDA- 2010/06/05 06:00
CRDT- 2010/02/04 06:00
PHST- 2010/02/04 06:00 [entrez]
PHST- 2010/02/04 06:00 [pubmed]
PHST- 2010/06/05 06:00 [medline]
AID - 0269216309351867 [pii]
AID - 10.1177/0269216309351867 [doi]
PST - ppublish
SO  - Palliat Med. 2010 Apr;24(3):306-9. doi: 10.1177/0269216309351867. Epub 2010 Feb
      1.


PMID- 20123902
OWN - NLM
STAT- MEDLINE
DCOM- 20100415
LR  - 20141120
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 254
IP  - 3
DP  - 2010 Mar
TI  - MR imaging correlates of intratumoral tissue types within colorectal liver
      metastases: a high-spatial-resolution fresh ex vivo radiologic-pathologic
      correlation study.
PG  - 747-54
LID - 10.1148/radiol.09090508 [doi]
AB  - PURPOSE: To analyze the direct relationship between complex internal magnetic
      resonance (MR) signal intensity (SI) patterns observed in colorectal liver
      metastases and their microscopic tissue characteristics. MATERIALS AND METHODS:
      The institutional ethics board approved this study. In seven consecutive patients
      undergoing hepatic resection for liver metastases (primary colorectal in six,
      breast mistaken for colorectal in one), the resected fresh ex vivo liver specimen
      was examined with T1-weighted (repetition time msec/echo time msec, 9/4.4-4.8)
      and T2-weighted (2500/90) MR imaging by using a voxel size of 0.47 x 0.7 x 2 mm. 
      The liver was sectioned in a concordant plane, and individual histologic slides
      were scanned and reconstructed to form a whole-mount pathologic image of the
      metastases. A pathologist identified the regions of interest for intraacinar
      necrosis (IAN), loose or dense fibrosis, and moderately and poorly differentiated
      cells within the metastases, and these regions were matched to the corresponding 
      MR image. The morphologic and SI patterns were noted. The normalized ratio
      between the SI of these regions and that of the background liver was determined
      on T1- and T2-weighted images. Pairwise differences between tissue types were
      calculated by using linear mixed model, with the P values adjusted for multiple
      comparisons by using the method of Sidak. RESULTS: A total of 98 zones were
      defined after pathologic analysis. On T2-weighted images, IAN was significantly
      lower in SI (P < .05) than the other tissues types. On T1-weighted images, IAN
      was significantly higher in SI than the other tissues types (P < .001). The type 
      of necrosis encountered in these specimens was exclusively IAN. Qualitatively IAN
      had a specific pattern of SI (hypointense on T2-weighted and hyperintense on
      T1-weighted images). Other tissues types, including fibrosis, showed a pattern of
      hyperintensity on T2-weighted and hypointensity on T1-weighted images.
      CONCLUSION: IAN seen in colorectal metastases exhibits high T1-weighted SI and
      mixed T2-weighted SI. This SI pattern is unusual for common benign liver lesions 
      and may be helpful in the MR imaging diagnosis of colorectal liver metastases.
      (c) RSNA, 2010.
FAU - Milot, Laurent
AU  - Milot L
AD  - Joint Department of Medical Imaging and Department of Radiation Oncology,
      Princess Margaret Hospital, Department of Pathology, and Division of General
      Surgery, University Health Network and Mount Sinai Hospital, University of
      Toronto, 610 University Ave, Toronto, ON, Canada M5G 2M9.
FAU - Guindi, Maha
AU  - Guindi M
FAU - Gallinger, Steven
AU  - Gallinger S
FAU - Moulton, Carol Anne
AU  - Moulton CA
FAU - Brock, Kristy K
AU  - Brock KK
FAU - Dawson, Laura A
AU  - Dawson LA
FAU - Haider, Masoom A
AU  - Haider MA
LA  - eng
PT  - Journal Article
DEP - 20100201
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adult
MH  - Aged
MH  - Colorectal Neoplasms/*pathology
MH  - Female
MH  - Humans
MH  - In Vitro Techniques
MH  - Linear Models
MH  - Liver Neoplasms/*diagnosis/*secondary
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prospective Studies
EDAT- 2010/02/04 06:00
MHDA- 2010/04/16 06:00
CRDT- 2010/02/04 06:00
PHST- 2010/02/04 06:00 [entrez]
PHST- 2010/02/04 06:00 [pubmed]
PHST- 2010/04/16 06:00 [medline]
AID - radiol.09090508 [pii]
AID - 10.1148/radiol.09090508 [doi]
PST - ppublish
SO  - Radiology. 2010 Mar;254(3):747-54. doi: 10.1148/radiol.09090508. Epub 2010 Feb 1.


PMID- 20123898
OWN - NLM
STAT- MEDLINE
DCOM- 20100415
LR  - 20220410
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 254
IP  - 3
DP  - 2010 Mar
TI  - Quantitative T2 mapping of knee cartilage: differentiation of healthy control
      cartilage and cartilage repair tissue in the knee with unloading--initial
      results.
PG  - 818-26
LID - 10.1148/radiol.09090335 [doi]
AB  - PURPOSE: To prospectively determine on T2 cartilage maps the effect of unloading 
      during a clinical magnetic resonance (MR) examination in the postoperative
      follow-up of patients after matrix-associated autologous chondrocyte
      transplantation (MACT) of the knee joint. MATERIALS AND METHODS: Ethical approval
      for this study was provided by the local ethics commission, and written informed 
      consent was obtained. Thirty patients (mean age, 35.4 years +/- 10.5) with a mean
      postoperative follow-up period of 29.1 months +/- 24.4 were enrolled. A multiecho
      spin-echo T2-weighted sequence was performed at the beginning (early unloading)
      and end (late unloading) of the MR examination, with an interval of 45 minutes.
      Mean and zonal region of interest T2 measurements were obtained in control
      cartilage and cartilage repair tissue. Statistical analysis of variance was
      performed. RESULTS: The change in T2 values of control cartilage (early
      unloading, 50.2 msec +/- 8.4; late unloading, 51.3 msec +/- 8.5) was less
      pronounced than the change in T2 values of cartilage repair tissue (early
      unloading, 51.8 msec +/- 11.7; late unloading, 56.1 msec +/- 14.4) (P = .024).
      The difference between control cartilage and cartilage repair tissue was not
      significant for early unloading (P = .314) but was significant for late unloading
      (P = .036). Zonal T2 measurements revealed a higher dependency on unloading for
      the superficial cartilage layer. CONCLUSION: Our results suggest that T2
      relaxation can be used to assess early and late unloading values of articular
      cartilage in a clinical setting and that the time point of the quantitative T2
      measurement affects the differentiation between native and abnormal articular
      cartilage. (c) RSNA, 2010.
FAU - Mamisch, Tallal C
AU  - Mamisch TC
AD  - Department of Orthopedic Surgery, University of Berne, Berne, Switzerland.
FAU - Trattnig, Siegfried
AU  - Trattnig S
FAU - Quirbach, Sebastian
AU  - Quirbach S
FAU - Marlovits, Stefan
AU  - Marlovits S
FAU - White, Lawrence M
AU  - White LM
FAU - Welsch, Goetz H
AU  - Welsch GH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100201
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 9004-61-9 (Hyaluronic Acid)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Analysis of Variance
MH  - Arthroscopy
MH  - Cartilage, Articular/pathology/*surgery
MH  - Chondrocytes/transplantation
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Hyaluronic Acid/pharmacology
MH  - Image Processing, Computer-Assisted
MH  - Knee Joint/pathology/*surgery
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Tissue Engineering
MH  - Treatment Outcome
MH  - Wound Healing
EDAT- 2010/02/04 06:00
MHDA- 2010/04/16 06:00
CRDT- 2010/02/04 06:00
PHST- 2010/02/04 06:00 [entrez]
PHST- 2010/02/04 06:00 [pubmed]
PHST- 2010/04/16 06:00 [medline]
AID - radiol.09090335 [pii]
AID - 10.1148/radiol.09090335 [doi]
PST - ppublish
SO  - Radiology. 2010 Mar;254(3):818-26. doi: 10.1148/radiol.09090335. Epub 2010 Feb 1.


PMID- 20123896
OWN - NLM
STAT- MEDLINE
DCOM- 20100506
LR  - 20220408
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 255
IP  - 1
DP  - 2010 Apr
TI  - Pulmonary ground-glass nodules: increase in mass as an early indicator of growth.
PG  - 199-206
LID - 10.1148/radiol.09090571 [doi]
AB  - PURPOSE: To compare manual measurements of diameter, volume, and mass of
      pulmonary ground-glass nodules (GGNs) to establish which method is best for
      identifying malignant GGNs by determining change across time. MATERIALS AND
      METHODS: In this ethics committee-approved retrospective study, baseline and
      follow-up CT examinations of 52 GGNs detected in a lung cancer screening trial
      were included, resulting in 127 GGN data sets for evaluation. Two observers
      measured GGN diameter with electronic calipers, manually outlined GGNs to obtain 
      volume and mass, and scored whether a solid component was present. Observer 1
      repeated all measurements after 2 months. Coefficients of variation and limits of
      agreement were calculated by using Bland-Altman methods. In a subgroup of GGNs
      containing all resected malignant lesions, the ratio between intraobserver
      variability and growth (growth-to-variability ratio) was calculated for each
      measurement technique. In this subgroup, the mean time for growth to exceed the
      upper limit of agreement of each measurement technique was determined. RESULTS:
      The kappa values for intra- and interobserver agreement for identifying a solid
      component were 0.55 and 0.38, respectively. Intra- and interobserver coefficients
      of variation were smallest for GGN mass (P < .001). Thirteen malignant GGNs were 
      resected. Mean growth-to-variability ratios were 11, 28, and 35 for diameter,
      volume, and mass, respectively (P = .03); mean times required for growth to
      exceed the upper limit of agreement were 715, 673, and 425 days, respectively (P 
      = .02). CONCLUSION: Mass measurements can enable detection of growth of GGNs
      earlier and are subject to less variability than are volume or diameter
      measurements.
CI  - RSNA, 2010
FAU - de Hoop, Bartjan
AU  - de Hoop B
AD  - Department of Radiology, University Medical Center, Heidelberglaan 100, 3584 CX
      Utrecht, The Netherlands. b.j.dehoop@umcutrecht.nl
FAU - Gietema, Hester
AU  - Gietema H
FAU - van de Vorst, Saskia
AU  - van de Vorst S
FAU - Murphy, Keelin
AU  - Murphy K
FAU - van Klaveren, Rob J
AU  - van Klaveren RJ
FAU - Prokop, Mathias
AU  - Prokop M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20100201
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
CIN - Radiology. 2010 Apr;255(1):16-8. PMID: 20308440
MH  - Aged
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/*diagnostic imaging/pathology
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Solitary Pulmonary Nodule/*diagnostic imaging/pathology
MH  - Tomography, X-Ray Computed/*methods
MH  - *Tumor Burden
EDAT- 2010/02/04 06:00
MHDA- 2010/05/07 06:00
CRDT- 2010/02/04 06:00
PHST- 2010/02/04 06:00 [entrez]
PHST- 2010/02/04 06:00 [pubmed]
PHST- 2010/05/07 06:00 [medline]
AID - radiol.09090571 [pii]
AID - 10.1148/radiol.09090571 [doi]
PST - ppublish
SO  - Radiology. 2010 Apr;255(1):199-206. doi: 10.1148/radiol.09090571. Epub 2010 Feb
      1.


PMID- 20123879
OWN - NLM
STAT- MEDLINE
DCOM- 20100518
LR  - 20191210
IS  - 1943-4723 (Electronic)
IS  - 0002-8177 (Linking)
VI  - 141
IP  - 2
DP  - 2010 Feb
TI  - Deciding about patients' requests for extraction: ethical and legal guidelines.
PG  - 195-203
AB  - BACKGROUND: and Overview. Dentists frequently are faced with patients' requests
      for an extraction, sometimes of the entire dentition. In this article, the
      authors offer guidelines to help dentists and oral surgeons make decisions
      regarding such requests for extraction. CONCLUSIONS: In most cases of patients'
      requesting extractions, the ethical principle of nonmaleficence will play a
      decisive role in the dentist's decision making. In cases in which the request
      appears influenced by a specific mental condition such as a phobia of dental
      treatment, extraction rarely is justifiable. Practice Implications. Dental
      professionals should keep in mind that they cannot be forced to carry out
      treatment that is at odds with the ethical principle of nonmaleficence or that is
      outside of the bounds of accepted treatment. To aid dentists in making treatment 
      decisions in such cases, the authors present a flowchart that integrates possible
      considerations.
FAU - Broers, Dyonne L M
AU  - Broers DL
AD  - Department for Dental Fear and Disabilities, Center for Special Care in
      Dentistry, Louwesweg 1, 1066 EA Amsterdam, Netherlands. d.broers@sbt.acta.n
FAU - Brands, Wolter G
AU  - Brands WG
FAU - Welie, Jos V M
AU  - Welie JV
FAU - de Jongh, Ad
AU  - de Jongh A
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Am Dent Assoc
JT  - Journal of the American Dental Association (1939)
JID - 7503060
SB  - IM
CIN - J Am Dent Assoc. 2010 May;141(5):503; author reply 503. PMID: 20436094
MH  - Adult
MH  - Body Dysmorphic Disorders/psychology
MH  - Conflict, Psychological
MH  - Cultural Diversity
MH  - *Decision Making
MH  - Dental Anxiety/psychology
MH  - Dental Care/standards
MH  - Dentist-Patient Relations
MH  - Dentists/*ethics/legislation & jurisprudence
MH  - Disclosure
MH  - *Ethics, Dental
MH  - Female
MH  - Humans
MH  - Informed Consent
MH  - Male
MH  - Mental Competency/legislation & jurisprudence
MH  - Patient Rights/*legislation & jurisprudence
MH  - *Personal Autonomy
MH  - Professional Autonomy
MH  - Refusal to Treat/ethics/legislation & jurisprudence
MH  - Social Values
MH  - Somatoform Disorders/psychology
MH  - Stress Disorders, Post-Traumatic/psychology
MH  - Tooth Extraction/*ethics
EDAT- 2010/02/04 06:00
MHDA- 2010/05/19 06:00
CRDT- 2010/02/04 06:00
PHST- 2010/02/04 06:00 [entrez]
PHST- 2010/02/04 06:00 [pubmed]
PHST- 2010/05/19 06:00 [medline]
AID - S0002-8177(14)63033-6 [pii]
AID - 10.14219/jada.archive.2010.0139 [doi]
PST - ppublish
SO  - J Am Dent Assoc. 2010 Feb;141(2):195-203. doi: 10.14219/jada.archive.2010.0139.


PMID- 20122286
OWN - NLM
STAT- MEDLINE
DCOM- 20100519
LR  - 20211020
IS  - 1472-6947 (Electronic)
IS  - 1472-6947 (Linking)
VI  - 10
DP  - 2010 Feb 3
TI  - Regression tree construction by bootstrap: model search for DRG-systems applied
      to Austrian health-data.
PG  - 9
LID - 10.1186/1472-6947-10-9 [doi]
AB  - BACKGROUND: DRG-systems are used to allocate resources fairly to hospitals based 
      on their performance. Statistically, this allocation is based on simple rules
      that can be modeled with regression trees. However, the resulting models often
      have to be adjusted manually to be medically reasonable and ethical. METHODS:
      Despite the possibility of manual, performance degenerating adaptations of the
      original model, alternative trees are systematically searched. The
      bootstrap-based method bumping is used to build diverse and accurate regression
      tree models for DRG-systems. A two-step model selection approach is proposed.
      First, a reasonable model complexity is chosen, based on statistical, medical and
      economical considerations. Second, a medically meaningful and accurate model is
      selected. An analysis of 8 data-sets from Austrian DRG-data is conducted and
      evaluated based on the possibility to produce diverse and accurate models for
      predefined tree complexities. RESULTS: The best bootstrap-based trees offer
      increased predictive accuracy compared to the trees built by the CART algorithm. 
      The analysis demonstrates that even for very small tree sizes, diverse models can
      be constructed being equally or even more accurate than the single model built by
      the standard CART algorithm. CONCLUSIONS: Bumping is a powerful tool to construct
      diverse and accurate regression trees, to be used as candidate models for
      DRG-systems. Furthermore, Bumping and the proposed model selection approach are
      also applicable to other medical decision and prognosis tasks.
FAU - Grubinger, Thomas
AU  - Grubinger T
AD  - Department of Medical Statistics, Informatics and Health Economics, Innsbruck
      Medical University, Schoepfstrasse 41/1, 6020 Innsbruck, Austria.
      thomas.grubinger@i-med.ac.at
FAU - Kobel, Conrad
AU  - Kobel C
FAU - Pfeiffer, Karl-Peter
AU  - Pfeiffer KP
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20100203
PL  - England
TA  - BMC Med Inform Decis Mak
JT  - BMC medical informatics and decision making
JID - 101088682
SB  - IM
MH  - *Algorithms
MH  - Austria
MH  - *Data Interpretation, Statistical
MH  - Decision Support Techniques
MH  - *Decision Trees
MH  - *Diagnosis-Related Groups
MH  - Humans
MH  - *Information Systems
MH  - Regression Analysis
PMC - PMC2828419
EDAT- 2010/02/04 06:00
MHDA- 2010/05/21 06:00
CRDT- 2010/02/04 06:00
PHST- 2009/10/08 00:00 [received]
PHST- 2010/02/03 00:00 [accepted]
PHST- 2010/02/04 06:00 [entrez]
PHST- 2010/02/04 06:00 [pubmed]
PHST- 2010/05/21 06:00 [medline]
AID - 1472-6947-10-9 [pii]
AID - 10.1186/1472-6947-10-9 [doi]
PST - epublish
SO  - BMC Med Inform Decis Mak. 2010 Feb 3;10:9. doi: 10.1186/1472-6947-10-9.


PMID- 20122086
OWN - NLM
STAT- MEDLINE
DCOM- 20110523
LR  - 20100203
IS  - 1744-6171 (Electronic)
IS  - 1073-6077 (Linking)
VI  - 23
IP  - 1
DP  - 2010 Feb
TI  - Reparative therapy: the adolescent, the psych nurse, and the issues.
PG  - 29-35
LID - 10.1111/j.1744-6171.2009.00214.x [doi]
AB  - TOPIC: Reparative therapy aims to modify the sexual orientation of lesbian, gay, 
      and bisexual (LGB) people into that of heterosexuals. Although denounced as
      harmful by most professional organizations, these treatments continue-youth may
      be particularly vulnerable to the negative consequences. PURPOSE: The purpose of 
      this article is to discuss reparative therapies, the potential harm LGB youth may
      experience, clinical and practice issues for psychiatric nurses, and the ethical 
      issues surrounding nurse involvement in reparative therapy. CONCLUSIONS:
      Reparative therapy for adolescents raises important clinical and ethical issues
      for psychiatric nursing. Further discussion of nurse involvement in these
      treatments is needed.
FAU - Hein, Laura C
AU  - Hein LC
AD  - University of South Carolina Columbia, Columbia, SC 29208, USA. Hein@sc.edu
FAU - Matthews, Alicia K
AU  - Matthews AK
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Child Adolesc Psychiatr Nurs
JT  - Journal of child and adolescent psychiatric nursing : official publication of the
      Association of Child and Adolescent Psychiatric Nurses, Inc
JID - 9431738
MH  - Adolescent
MH  - *Bisexuality/psychology
MH  - Female
MH  - Heterosexuality
MH  - *Homosexuality/psychology
MH  - Humans
MH  - Male
MH  - Psychiatric Nursing/*ethics
MH  - Psychotherapy/*ethics/methods
MH  - Young Adult
EDAT- 2010/02/04 06:00
MHDA- 2011/05/24 06:00
CRDT- 2010/02/04 06:00
PHST- 2010/02/04 06:00 [entrez]
PHST- 2010/02/04 06:00 [pubmed]
PHST- 2011/05/24 06:00 [medline]
AID - JCAP214 [pii]
AID - 10.1111/j.1744-6171.2009.00214.x [doi]
PST - ppublish
SO  - J Child Adolesc Psychiatr Nurs. 2010 Feb;23(1):29-35. doi:
      10.1111/j.1744-6171.2009.00214.x.


PMID- 20121777
OWN - NLM
STAT- MEDLINE
DCOM- 20100308
LR  - 20131121
IS  - 1365-2044 (Electronic)
IS  - 0003-2409 (Linking)
VI  - 65
IP  - 1
DP  - 2010 Jan
TI  - Ethical issues and donor numbers.
PG  - 84
LID - 10.1111/j.1365-2044.2009.06171.x [doi]
FAU - Cottle, D
AU  - Cottle D
FAU - Dean, P
AU  - Dean P
LA  - eng
PT  - Case Reports
PT  - Comment
PT  - Letter
PL  - England
TA  - Anaesthesia
JT  - Anaesthesia
JID - 0370524
RN  - 614OI1Z5WI (Valproic Acid)
SB  - IM
CON - Anaesthesia. 2009 Aug;64(8):822-8. PMID: 19604184
CIN - Anaesthesia. 2010 Jun;65(6):646-7. PMID: 20565396
CIN - Anaesthesia. 2010 Jun;65(6):646. PMID: 20565397
MH  - Brain Death/diagnosis
MH  - Ethics, Clinical
MH  - Humans
MH  - Hyperammonemia/chemically induced
MH  - Male
MH  - Tissue Donors/*ethics
MH  - Tissue and Organ Procurement/*ethics
MH  - Valproic Acid/poisoning
MH  - Young Adult
EDAT- 2010/02/04 06:00
MHDA- 2010/03/10 06:00
CRDT- 2010/02/04 06:00
PHST- 2010/02/04 06:00 [entrez]
PHST- 2010/02/04 06:00 [pubmed]
PHST- 2010/03/10 06:00 [medline]
AID - ANA6171 [pii]
AID - 10.1111/j.1365-2044.2009.06171.x [doi]
PST - ppublish
SO  - Anaesthesia. 2010 Jan;65(1):84. doi: 10.1111/j.1365-2044.2009.06171.x.


PMID- 20121493
OWN - NLM
STAT- MEDLINE
DCOM- 20100430
LR  - 20220310
IS  - 1364-6893 (Electronic)
IS  - 0144-3615 (Linking)
VI  - 30
IP  - 1
DP  - 2010 Jan
TI  - A review of the EXIT (Ex utero Intrapartum Treatment) procedure.
PG  - 1-5
LID - 10.3109/01443610903281656 [doi]
AB  - The EXIT (Ex utero Intrapartum Treatment) procedure is done in cases where
      difficulty is anticipated in neonatal airway establishment at delivery and is
      done at the time of caesarean section. The partially delivered fetus is
      maintained on placental circulation while airway is established and this is
      carried out by a multidisciplinary team. In this paper, we review the
      indications, the maternal and fetal considerations of the procedure and the
      results and outcomes. The review highlights the fact that the benefits far
      outweigh the risks and that the risk of postpartum haemorrhage is more
      theoretical than real. As technology improves and more anomalies are diagnosed
      during the antenatal period, the EXIT procedure can be performed with good
      results after carefully considering the ethical issues. We have performed a
      MEDLINE search by using the keywords EXIT, CHAOS, fetal surgery, fetal neck
      masses and ex utero intrapartum treatment. As there are not many large studies,
      we have also reviewed smaller case series and case reports.
FAU - Abraham, R J
AU  - Abraham RJ
AD  - Department of Obstetrics and Gynaecology, Huddersfield Royal Infirmary,
      Huddersfield, UK. ashis.sau@uhl.nhs.uk
FAU - Sau, A
AU  - Sau A
FAU - Maxwell, D
AU  - Maxwell D
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Obstet Gynaecol
JT  - Journal of obstetrics and gynaecology : the journal of the Institute of
      Obstetrics and Gynaecology
JID - 8309140
SB  - IM
MH  - Airway Obstruction/diagnosis/*surgery
MH  - Anesthesia, Obstetrical/*adverse effects
MH  - Cesarean Section
MH  - Female
MH  - Fetal Diseases/diagnosis/*surgery
MH  - Fetal Monitoring
MH  - *Fetal Therapies
MH  - Humans
MH  - Postoperative Complications/*etiology
MH  - Postpartum Hemorrhage/*etiology
MH  - Pregnancy
MH  - Prenatal Diagnosis
MH  - Treatment Outcome
RF  - 18
EDAT- 2010/02/04 06:00
MHDA- 2010/05/01 06:00
CRDT- 2010/02/04 06:00
PHST- 2010/02/04 06:00 [entrez]
PHST- 2010/02/04 06:00 [pubmed]
PHST- 2010/05/01 06:00 [medline]
AID - 10.3109/01443610903281656 [doi]
PST - ppublish
SO  - J Obstet Gynaecol. 2010 Jan;30(1):1-5. doi: 10.3109/01443610903281656.


PMID- 20120167
OWN - NLM
STAT- MEDLINE
DCOM- 20100427
LR  - 20100202
IS  - 1708-1890 (Print)
IS  - 1708-1890 (Linking)
VI  - 7
IP  - 1
DP  - 2010 Jan-Feb
TI  - [Home concerns and ethical questions].
PG  - 12; discussion 12
FAU - Cloutier, Ginette
AU  - Cloutier G
LA  - fre
PT  - Letter
TT  - Soins a domicile et questions ethiques.
PL  - Canada
TA  - Perspect Infirm
JT  - Perspective infirmiere : revue officielle de l'Ordre des infirmieres et
      infirmiers du Quebec
JID - 101196674
MH  - *Ethics, Nursing
MH  - Humans
MH  - Quebec
MH  - Societies, Nursing
EDAT- 2010/02/03 06:00
MHDA- 2010/04/28 06:00
CRDT- 2010/02/03 06:00
PHST- 2010/02/03 06:00 [entrez]
PHST- 2010/02/03 06:00 [pubmed]
PHST- 2010/04/28 06:00 [medline]
PST - ppublish
SO  - Perspect Infirm. 2010 Jan-Feb;7(1):12; discussion 12.


PMID- 20118720
OWN - NLM
STAT- MEDLINE
DCOM- 20100224
LR  - 20100201
IS  - 1532-3145 (Electronic)
IS  - 0363-8715 (Linking)
VI  - 34
IP  - 1
DP  - 2010 Jan
TI  - Radiation dose reduction with chest computed tomography using adaptive
      statistical iterative reconstruction technique: initial experience.
PG  - 40-5
LID - 10.1097/RCT.0b013e3181b26c67 [doi]
AB  - PURPOSE: To assess radiation dose reduction and image quality for weight-based
      chest computed tomographic (CT) examination results reconstructed using adaptive 
      statistical iterative reconstruction (ASIR) technique. MATERIALS AND METHODS:
      With local ethical committee approval, weight-adjusted chest CT examinations were
      performed using ASIR in 98 patients and filtered backprojection (FBP) in 54
      weight-matched patients on a 64-slice multidetector CT. Patients were categorized
      into 3 groups: 60 kg or less (n = 32), 61 to 90 kg (n = 77), and 91 kg or more (n
      = 43) for weight-based adjustment of noise indices for automatic exposure control
      (Auto mA; GE Healthcare, Waukesha, Wis). Remaining scan parameters were held
      constant at 0.984:1 pitch, 120 kilovolts (peak), 40-mm table feed per rotation,
      and 2.5-mm section thickness. Patients' weight, scanning parameters, and CT dose 
      index volume were recorded. Effective doses (EDs) were estimated. Image noise was
      measured in the descending thoracic aorta at the level of the carina. Data were
      analyzed using analysis of variance. RESULTS: Compared with FBP, ASIR was
      associated with an overall mean (SD) decrease of 27.6% in ED (ASIR, 8.8 [2.3]
      mSv; FBP, 12.2 [2.1] mSv; P < 0.0001). With the use of ASIR, the ED values were
      6.5 (1.8) mSv (28.8% decrease), 7.3 (1.6) mSv (27.3% decrease), and 12.8 (2.3)
      mSv (26.8% decrease) for the weight groups of 60 kg or less, 61 to 90 kg, and 91 
      kg or more, respectively, compared with 9.2 (2.3) mSv, 10.0 (2.0) mSv, and 17.4
      (2.1) mSv with FBP (P < 0.0001). Despite dose reduction, there was less noise
      with ASIR (12.6 [2.9] mSv) than with FBP (16.6 [6.2] mSv; P < 0.0001).
      CONCLUSIONS: Adaptive statistical iterative reconstruction helps reduce chest CT 
      radiation dose and improve image quality compared with the conventionally used
      FBP image reconstruction.
FAU - Prakash, Priyanka
AU  - Prakash P
AD  - Division of Thoracic Imaging, Department of Radiology, Massachusetts General
      Hospital and Harvard Medical School, Boston, MA 02114, USA.
FAU - Kalra, Mannudeep K
AU  - Kalra MK
FAU - Digumarthy, Subba R
AU  - Digumarthy SR
FAU - Hsieh, Jiang
AU  - Hsieh J
FAU - Pien, Homer
AU  - Pien H
FAU - Singh, Sarabjeet
AU  - Singh S
FAU - Gilman, Matthew D
AU  - Gilman MD
FAU - Shepard, Jo-Anne O
AU  - Shepard JA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Comput Assist Tomogr
JT  - Journal of computer assisted tomography
JID - 7703942
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted/*methods
MH  - Male
MH  - Middle Aged
MH  - Observer Variation
MH  - *Radiation Dosage
MH  - Radiography, Thoracic/*methods
MH  - Retrospective Studies
MH  - Sex Distribution
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2010/02/02 06:00
MHDA- 2010/02/25 06:00
CRDT- 2010/02/02 06:00
PHST- 2010/02/02 06:00 [entrez]
PHST- 2010/02/02 06:00 [pubmed]
PHST- 2010/02/25 06:00 [medline]
AID - 10.1097/RCT.0b013e3181b26c67 [doi]
AID - 00004728-201001000-00008 [pii]
PST - ppublish
SO  - J Comput Assist Tomogr. 2010 Jan;34(1):40-5. doi: 10.1097/RCT.0b013e3181b26c67.


PMID- 20118703
OWN - NLM
STAT- MEDLINE
DCOM- 20110113
LR  - 20151119
IS  - 1559-7776 (Electronic)
IS  - 1559-7768 (Linking)
VI  - 21
IP  - 1
DP  - 2010 Jan-Mar
TI  - Introduction: interview with Barbara J. Daly, RN, PhD, FAAN, Gertrude Perkins
      Oliva Professor of Oncology Nursing, Case Western Reserve University, and
      Director, Clinical Ethics, University Hospitals Case Medical Center. Interviewed 
      by Clareen Wiencek.
PG  - 41-3
LID - 10.1097/NCI.0b013e3181c9653a [doi]
FAU - Daly, Barbara J
AU  - Daly BJ
LA  - eng
PT  - Interview
PL  - United States
TA  - AACN Adv Crit Care
JT  - AACN advanced critical care
JID - 101269322
MH  - Advanced Practice Nursing
MH  - Chronic Disease
MH  - *Critical Care
MH  - Critical Illness/*nursing
MH  - Decision Making
MH  - *Disease Management
MH  - Humans
MH  - *Intensive Care Units
MH  - *Program Development
MH  - Program Evaluation
EDAT- 2010/02/02 06:00
MHDA- 2011/01/14 06:00
CRDT- 2010/02/02 06:00
PHST- 2010/02/02 06:00 [entrez]
PHST- 2010/02/02 06:00 [pubmed]
PHST- 2011/01/14 06:00 [medline]
AID - 10.1097/NCI.0b013e3181c9653a [doi]
AID - 01256961-201001000-00007 [pii]
PST - ppublish
SO  - AACN Adv Crit Care. 2010 Jan-Mar;21(1):41-3. doi: 10.1097/NCI.0b013e3181c9653a.


PMID- 20118021
OWN - NLM
STAT- MEDLINE
DCOM- 20110113
LR  - 20131121
IS  - 1538-067X (Electronic)
IS  - 1092-1095 (Linking)
VI  - 14
IP  - 1
DP  - 2010 Feb
TI  - Moral distress: a consequence of caring.
PG  - 25-7
LID - 10.1188/10.CJON.25-27 [doi]
AB  - With the increase of technology in health care, oncology nurses often are
      involved in ethical discussions regarding the best use of aggressive
      interventions for patients. Conflicts between ethical principles and external
      forces can produce moral distress for oncology nurses caring for people with
      cancer. Moral distress can impact nurses in significant ways, including mental
      health and job satisfaction, and may impact care delivery. This article reviews
      the concept of moral distress and suggests interventions and future research to
      minimize its impact on nurses and patients.
FAU - Shepard, Agnes
AU  - Shepard A
AD  - University of Texas M.D. Anderson Cancer Center, Houston, USA.
      nycshepard@gmail.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin J Oncol Nurs
JT  - Clinical journal of oncology nursing
JID - 9705336
MH  - Adaptation, Psychological
MH  - *Ethics, Nursing
MH  - Humans
MH  - Job Satisfaction
MH  - Medical Laboratory Science/ethics
MH  - *Morals
MH  - Neoplasms/*nursing
MH  - *Oncology Nursing
MH  - Psychometrics
MH  - *Stress, Psychological
EDAT- 2010/02/02 06:00
MHDA- 2011/01/14 06:00
CRDT- 2010/02/02 06:00
PHST- 2010/02/02 06:00 [entrez]
PHST- 2010/02/02 06:00 [pubmed]
PHST- 2011/01/14 06:00 [medline]
AID - A828406743M0105L [pii]
AID - 10.1188/10.CJON.25-27 [doi]
PST - ppublish
SO  - Clin J Oncol Nurs. 2010 Feb;14(1):25-7. doi: 10.1188/10.CJON.25-27.


PMID- 20117912
OWN - NLM
STAT- MEDLINE
DCOM- 20100630
LR  - 20131121
IS  - 1769-6623 (Electronic)
IS  - 0750-7658 (Linking)
VI  - 29
IP  - 2
DP  - 2010 Feb
TI  - [Impact of intrathecal morphine on the tolerance of early feeding after cesarean 
      section].
PG  - 113-6
LID - 10.1016/j.annfar.2009.12.015 [doi]
AB  - INTRODUCTION: Early feeding is well tolerated in patients undergoing caesarean
      section under general or regional anaesthesia. Intrathecal morphine is effective 
      for postoperative analgesia but can induce nausea and vomiting which may hamper
      feeding. This study assessed prospectively the effects of intrathecal morphine on
      early feeding in patients undergoing caesarean section. METHODOLOGY: After
      ethical committee approval, 66 consenting women scheduled for caesarean section
      were randomized to receive intrathecal morphine 0.1 mg (group M, n=32) or not
      ("control group", group C, n=34) at the time of intrathecal anaesthesia performed
      with a 3 ml mixture containing 8.6 mg bupivacaine, 64 microg clonidine and 4.3
      microg sufentanil. Standard antiemetic prophylaxis (5 mg dexamethasone + 2 mg
      tropisetron) was administered intravenously in all patients after umbilical cord 
      clamping. Standardized multimodal analgesia was initiated postoperatively with 1 
      g of paracetamol and 30 mg of ketorolac given every 6 hours. Analgesia was
      evaluated by a numeric rating scale (NRS) at 4 hours intervals and 10 mg of oral 
      morphine was administered if the NRS score exceeded 3. All patients received a
      protein enriched solution, 8 hours after caesarean section and were allowed to
      eat solid food on postoperative day 1. Nausea and vomiting episodes, gas and/or
      stools emission, itching, NRS score and morphine consumption were recorded on the
      first, second and fourth postoperative hour and then every 4 hours during 48
      hours. RESULTS: Nausea was significantly more frequent and persisted longer in
      group M. Vomiting occurred equally in both groups and stopped after feeding. Gas 
      and/or stools emission appeared within 48 hours postoperatively in 72 and 77 % of
      patients in group M and group C respectively. Oral morphine consumption was
      significantly lower in group M (1.9+/-4 vs 6.5+/-7.3mg, p=0.006). When compared
      to group C, NRS were also lower in group M from the second to the 20th
      postoperative hour. Itching was observed more frequently and persisted longer in 
      group M. DISCUSSION AND CONCLUSION: A small dose of intrathecal morphine provided
      adequate and prolonged pain relief after caesarean section but increased the
      incidence of nausea and vomiting despite anti-emetic prophylaxis. Oral food
      intake was not hampered by intrathecal morphine.
CI  - Copyright (c) 2009 Elsevier Masson SAS. All rights reserved.
FAU - Tshibangu-N, A
AU  - Tshibangu-N A
AD  - CHU Brugmann, 4 place A.-Van Gehucten, Brussels, Belgium. tshib.annie@hotmail.com
FAU - Motte-Neuville, F
AU  - Motte-Neuville F
FAU - Gepts, E
AU  - Gepts E
FAU - Bailly, A
AU  - Bailly A
FAU - Nguyen, T
AU  - Nguyen T
FAU - Hirsoux, L
AU  - Hirsoux L
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Randomized Controlled Trial
TT  - Morphine intrathecale et tolerance de l'alimentation precoce post-cesarienne.
DEP - 20100201
PL  - France
TA  - Ann Fr Anesth Reanim
JT  - Annales francaises d'anesthesie et de reanimation
JID - 8213275
RN  - 0 (Analgesics, Opioid)
RN  - 76I7G6D29C (Morphine)
SB  - IM
MH  - Adult
MH  - Analgesics, Opioid/*administration & dosage
MH  - *Cesarean Section
MH  - *Eating
MH  - Female
MH  - Humans
MH  - Injections, Spinal
MH  - Morphine/*administration & dosage
MH  - Pain, Postoperative/*prevention & control
MH  - Postoperative Care
MH  - Pregnancy
MH  - Prospective Studies
MH  - Time Factors
EDAT- 2010/02/02 06:00
MHDA- 2010/07/01 06:00
CRDT- 2010/02/02 06:00
PHST- 2007/10/03 00:00 [received]
PHST- 2009/12/09 00:00 [accepted]
PHST- 2010/02/02 06:00 [entrez]
PHST- 2010/02/02 06:00 [pubmed]
PHST- 2010/07/01 06:00 [medline]
AID - S0750-7658(09)00659-5 [pii]
AID - 10.1016/j.annfar.2009.12.015 [doi]
PST - ppublish
SO  - Ann Fr Anesth Reanim. 2010 Feb;29(2):113-6. doi: 10.1016/j.annfar.2009.12.015.
      Epub 2010 Feb 1.


PMID- 20117684
OWN - NLM
STAT- MEDLINE
DCOM- 20100408
LR  - 20191210
IS  - 1532-8228 (Electronic)
IS  - 0883-9417 (Linking)
VI  - 24
IP  - 1
DP  - 2010 Feb
TI  - Restraints and the code of ethics: An uneasy fit.
PG  - 3-14
LID - 10.1016/j.apnu.2009.03.003 [doi]
AB  - This article examines the use of physical restraints through the four broad
      principles of ethics common to all helping professions. It asks whether the
      continued use of physical restraints is consistent with ethical practice through 
      the lens of those principles. It also examines where the necessity to use
      restraints in the absence of empirically supported alternatives leaves
      professionals in terms of conflicts between ethical principles and makes
      recommendations for changes in education and clinical practice. It concludes that
      an analysis through a bioethics lens demonstrates that the use of restraints as a
      tool in psychiatric settings is a complex and multifaceted problem. Principles of
      ethics may often be in conflict with each other in instances where patients must 
      be physically restrained.
CI  - 2009 Elsevier Inc. All rights reserved.
FAU - Mohr, Wanda K
AU  - Mohr WK
AD  - UMDNJ School of Nursing, Stratford, NJ 07107-3001, USA. mohrwk@umdnj.edu
LA  - eng
PT  - Journal Article
DEP - 20090806
PL  - United States
TA  - Arch Psychiatr Nurs
JT  - Archives of psychiatric nursing
JID - 8708534
SB  - IM
MH  - Attitude of Health Personnel
MH  - Authoritarianism
MH  - Benchmarking
MH  - *Codes of Ethics
MH  - Coercion
MH  - Conflict, Psychological
MH  - Ethical Analysis
MH  - Humans
MH  - Patient Advocacy/ethics
MH  - Patient Selection/ethics
MH  - *Principle-Based Ethics
MH  - Psychiatric Nursing/education/*ethics/methods
MH  - Restraint, Physical/adverse effects/*ethics
MH  - Safety Management/ethics
MH  - United States
EDAT- 2010/02/02 06:00
MHDA- 2010/04/09 06:00
CRDT- 2010/02/02 06:00
PHST- 2008/12/06 00:00 [received]
PHST- 2009/02/15 00:00 [revised]
PHST- 2009/03/24 00:00 [accepted]
PHST- 2010/02/02 06:00 [entrez]
PHST- 2010/02/02 06:00 [pubmed]
PHST- 2010/04/09 06:00 [medline]
AID - S0883-9417(09)00043-0 [pii]
AID - 10.1016/j.apnu.2009.03.003 [doi]
PST - ppublish
SO  - Arch Psychiatr Nurs. 2010 Feb;24(1):3-14. doi: 10.1016/j.apnu.2009.03.003. Epub
      2009 Aug 6.


PMID- 20117678
OWN - NLM
STAT- MEDLINE
DCOM- 20100408
LR  - 20100201
IS  - 1532-8449 (Electronic)
IS  - 0882-5963 (Linking)
VI  - 25
IP  - 1
DP  - 2010 Feb
TI  - Parental preference or child well-being: an ethical dilemma.
PG  - 58-63
LID - 10.1016/j.pedn.2009.04.007 [doi]
AB  - An ethical dilemma that is not uncommon to encounter when caring for children
      occurs when parental preference does not appear to be in the child's best
      interest. Challenges facing the health care team are further amplified when the
      family's cultural background does not match that of the team. A case study will
      be used to illustrate the challenges of a pediatric palliative care ethical
      dilemma further complicated by cultural diversity. Review of the child's medical 
      condition, patient/parent preferences, quality of life, and contextual features
      will be followed by an analysis and recommendations for resolution of this
      challenging situation.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Turner, Helen N
AU  - Turner HN
AD  - Pediatric Pain Management Center, Doernbecher Children's Hospital, Oregon Health 
      & Science University, Portland, OR, USA. turnerh@ohsu.edu
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20090702
PL  - United States
TA  - J Pediatr Nurs
JT  - Journal of pediatric nursing
JID - 8607529
SB  - IM
CIN - J Pediatr Nurs. 2010 Apr;25(2):71. PMID: 20185056
MH  - Asian Americans/*ethnology
MH  - Attitude to Health/ethnology
MH  - Child
MH  - Child Advocacy/*ethics
MH  - Choice Behavior/ethics
MH  - Developmental Disabilities/ethnology/nursing
MH  - Dissent and Disputes
MH  - Ethical Analysis
MH  - Female
MH  - Humans
MH  - Palliative Care/*ethics/psychology
MH  - Parents/*psychology
MH  - Pediatric Nursing/ethics
MH  - Principle-Based Ethics
MH  - Proteus Syndrome/ethnology/nursing
MH  - Quality of Life
EDAT- 2010/02/02 06:00
MHDA- 2010/04/09 06:00
CRDT- 2010/02/02 06:00
PHST- 2008/12/22 00:00 [received]
PHST- 2009/04/16 00:00 [revised]
PHST- 2009/04/17 00:00 [accepted]
PHST- 2010/02/02 06:00 [entrez]
PHST- 2010/02/02 06:00 [pubmed]
PHST- 2010/04/09 06:00 [medline]
AID - S0882-5963(09)00121-3 [pii]
AID - 10.1016/j.pedn.2009.04.007 [doi]
PST - ppublish
SO  - J Pediatr Nurs. 2010 Feb;25(1):58-63. doi: 10.1016/j.pedn.2009.04.007. Epub 2009 
      Jul 2.


PMID- 20116335
OWN - NLM
STAT- MEDLINE
DCOM- 20100603
LR  - 20100811
IS  - 1532-1932 (Electronic)
IS  - 1521-6934 (Linking)
VI  - 24
IP  - 1
DP  - 2010 Feb
TI  - Cryopreservation of oocytes and embryos for fertility preservation for female
      cancer patients.
PG  - 101-12
LID - 10.1016/j.bpobgyn.2009.11.007 [doi]
AB  - In vitro fertilization and embryo cryopreservation is regarded as the only
      established method for fertility preservation in female cancer patients. However,
      a possible delay in treatment of the primary disease due to ovarian stimulation, 
      exposure to supraphysiologic estrogen levels induced by ovarian stimulation, the 
      requirement for a male partner or willingness to use donor sperm for embryo
      production, legal, ethical, religious issues related to cryopreservation of
      embryos raise concerns for patients and physicians. Recent improvements achieved 
      with oocyte vitrification have increased the effectiveness of oocyte
      cryopreservation rendering it a viable option, especially for patients without a 
      male partner. In vitro maturation avoids treatment delay or exposure to increased
      estradiol levels associated with ovarian stimulation for in vitro fertilization. 
      In vitro maturation combined with embryo or oocyte vitrification provides
      previously unavailable options for some patients and improves the services
      provided by a fertility preservation program.
FAU - Ata, Baris
AU  - Ata B
AD  - McGill Reproductive Centre, Department of Obstetrics and Gynecology, Division of 
      Reproductive Endocrinology and Infertility, McGill University, Royal Victoria
      Hospital, 687 Pine Avenue West, H3A 1A1, Montreal, Quebec, Canada.
      baris.ata@muhc.mcgill.ca <baris.ata@muhc.mcgill.ca>
FAU - Chian, Ri-Cheng
AU  - Chian RC
FAU - Tan, Seang Lin
AU  - Tan SL
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100208
PL  - Netherlands
TA  - Best Pract Res Clin Obstet Gynaecol
JT  - Best practice & research. Clinical obstetrics & gynaecology
JID - 101121582
SB  - IM
MH  - Adult
MH  - Breast Neoplasms/therapy
MH  - *Cryopreservation/methods
MH  - *Embryo Transfer
MH  - Female
MH  - *Fertility
MH  - Fertilization in Vitro/*methods
MH  - Genital Neoplasms, Female/therapy
MH  - Humans
MH  - Infertility/*prevention & control
MH  - Male
MH  - Neoplasms/*therapy
MH  - *Oocytes
MH  - Treatment Outcome
RF  - 73
EDAT- 2010/02/02 06:00
MHDA- 2010/06/04 06:00
CRDT- 2010/02/02 06:00
PHST- 2009/11/23 00:00 [received]
PHST- 2009/11/24 00:00 [accepted]
PHST- 2010/02/02 06:00 [entrez]
PHST- 2010/02/02 06:00 [pubmed]
PHST- 2010/06/04 06:00 [medline]
AID - S1521-6934(09)00145-X [pii]
AID - 10.1016/j.bpobgyn.2009.11.007 [doi]
PST - ppublish
SO  - Best Pract Res Clin Obstet Gynaecol. 2010 Feb;24(1):101-12. doi:
      10.1016/j.bpobgyn.2009.11.007. Epub 2010 Feb 8.


PMID- 20116190
OWN - NLM
STAT- MEDLINE
DCOM- 20100528
LR  - 20191210
IS  - 0398-7620 (Print)
IS  - 0398-7620 (Linking)
VI  - 58
IP  - 1
DP  - 2010 Feb
TI  - [Research and non-research. The values in the evaluation of epidemiological
      protocols].
PG  - 41-8
LID - 10.1016/j.respe.2009.09.006 [doi]
AB  - BACKGROUND: Evaluation and ethical review of epidemiological research projects
      raises the problem of the limits between research and non-research. This
      ambiguous boundary reflects the status of this discipline at the crossroads
      between research and practical action. The question then is: in the field of
      health research, what gives data collection and analysis its quality of
      scientific activity? METHODS: A conceptual and empirical study has been conducted
      about the practices of epidemiological research evaluation, centred on the case
      of the French Consultative Committee for the data processing in health research
      (CCTIRS), which is a consultative board that permits the National commission for 
      the personal data protection (CNIL) to take decision about health research
      protocols that process personal data. The study was realized from 2003 to 2006.
      RESULTS: It is shown that the evaluation of such research protocols processing
      personal data articulates intimately two kinds of criteria: methodology and
      relevance. By studying and characterizing the different kinds of protocols that
      are judged not to be "scientific research" (poor science, pseudo-science and
      non-science), it becomes possible to understand the motives that lead to
      distinguish between what is and what is not research in epidemiology. A special
      attention is given to two kinds of problematic cases: firstly, the case of
      conflict of interests into the protocols themselves (i.e. seeding trials or
      surveys); secondly, the problem of epidemiological registers and other databases 
      which are not hypothesis-oriented. This last case leads to relate the conceptual 
      frame of the committee with historical circumstances (the way which this
      discipline was introduced in France) and also mere epistemological considerations
      (the question of induction and generalizability). CONCLUSION: The activity of
      this committee illustrates a differentiated conception of what is research in
      epidemiology, influenced by explanatory analytical research paradigms. Finally,
      the field of epidemiological research appears to be structured by some values
      that appear through the elaboration and the application of the ethical and
      regulatory texts.
FAU - Lechopier, N
AU  - Lechopier N
AD  - Institut d'histoire et de philosophie des sciences et des techniques, 13, rue du 
      Four, 75006 Paris, France. nicolas.lechopier@laposte.net
      <nicolas.lechopier@laposte.net>
LA  - fre
PT  - Evaluation Study
PT  - Journal Article
TT  - Recherche et non-recherche. Les valeurs a l'oeuvre dans l'evaluation des
      protocoles epidemiologiques.
DEP - 20100129
PL  - France
TA  - Rev Epidemiol Sante Publique
JT  - Revue d'epidemiologie et de sante publique
JID - 7608039
SB  - IM
MH  - Advisory Committees
MH  - *Clinical Protocols/standards
MH  - Confidentiality/ethics/legislation & jurisprudence/standards
MH  - Conflict of Interest
MH  - Data Collection
MH  - Data Interpretation, Statistical
MH  - *Epidemiologic Methods
MH  - Epidemiologic Research Design
MH  - Epidemiologic Studies
MH  - *Epidemiology/ethics/organization & administration
MH  - Ethical Review
MH  - France
MH  - Humans
MH  - Organizational Objectives
MH  - Patient Rights/ethics/legislation & jurisprudence/standards
MH  - Philosophy, Dental
MH  - Registries
MH  - Science
MH  - Scientific Misconduct/ethics/legislation & jurisprudence
EDAT- 2010/02/02 06:00
MHDA- 2010/05/29 06:00
CRDT- 2010/02/02 06:00
PHST- 2009/04/07 00:00 [received]
PHST- 2009/09/09 00:00 [revised]
PHST- 2009/09/18 00:00 [accepted]
PHST- 2010/02/02 06:00 [entrez]
PHST- 2010/02/02 06:00 [pubmed]
PHST- 2010/05/29 06:00 [medline]
AID - S0398-7620(09)00523-9 [pii]
AID - 10.1016/j.respe.2009.09.006 [doi]
PST - ppublish
SO  - Rev Epidemiol Sante Publique. 2010 Feb;58(1):41-8. doi:
      10.1016/j.respe.2009.09.006. Epub 2010 Jan 29.


PMID- 20115967
OWN - NLM
STAT- MEDLINE
DCOM- 20100312
LR  - 20151119
IS  - 1097-6817 (Electronic)
IS  - 0194-5998 (Linking)
VI  - 142
IP  - 2
DP  - 2010 Feb
TI  - Practitioners need corporate compliance education: AAO-HNS survey results.
PG  - 160-3
LID - 10.1016/j.otohns.2009.10.018 [doi]
AB  - The environment in which otolaryngologists coexist with device and drug
      development has become increasingly complex. There are broad implications for
      both the academic and the private practitioner, with neither group being more or 
      less insulated than the other. From the medical, ethical, and resource-oriented
      standpoints, otolaryngologists must consider this evolving area very carefully. A
      survey of the American Association of Otolaryngology-Head and Neck Surgery
      membership identified areas of education to improve the awareness and knowledge
      base of these complex considerations. In particular, knowledge of legal
      proceedings, Food and Drug Administration processes, relevant hospital resources,
      and conflict of interest considerations were areas in which the membership would 
      benefit from further instruction.
CI  - Copyright 2010 American Academy of Otolaryngology-Head and Neck Surgery
      Foundation. Published by Mosby, Inc. All rights reserved.
FAU - Devaiah, Anand
AU  - Devaiah A
AD  - Departments of Otolaryngology-Head and Neck Surgery, and Neurological Surgery,
      Boston University School of Medicine, Boston, MA, USA.
FAU - Jacobowitz, Ofer
AU  - Jacobowitz O
FAU - Siegel, Gordy
AU  - Siegel G
FAU - Shah, Udayan K
AU  - Shah UK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Otolaryngol Head Neck Surg
JT  - Otolaryngology--head and neck surgery : official journal of American Academy of
      Otolaryngology-Head and Neck Surgery
JID - 8508176
SB  - IM
MH  - Conflict of Interest
MH  - Consumer Product Safety/legislation & jurisprudence
MH  - Economics, Hospital
MH  - *Education, Medical, Continuing
MH  - Ethics, Business/*education
MH  - Health Surveys
MH  - Humans
MH  - Logistic Models
MH  - Otolaryngology/*education/legislation & jurisprudence
MH  - *Physician's Role
MH  - Surveys and Questionnaires
MH  - United States
MH  - United States Food and Drug Administration/legislation & jurisprudence
EDAT- 2010/02/02 06:00
MHDA- 2010/03/13 06:00
CRDT- 2010/02/02 06:00
PHST- 2009/06/25 00:00 [received]
PHST- 2009/09/25 00:00 [revised]
PHST- 2009/10/14 00:00 [accepted]
PHST- 2010/02/02 06:00 [entrez]
PHST- 2010/02/02 06:00 [pubmed]
PHST- 2010/03/13 06:00 [medline]
AID - S0194-5998(09)01613-1 [pii]
AID - 10.1016/j.otohns.2009.10.018 [doi]
PST - ppublish
SO  - Otolaryngol Head Neck Surg. 2010 Feb;142(2):160-3. doi:
      10.1016/j.otohns.2009.10.018.


PMID- 20113993
OWN - NLM
STAT- MEDLINE
DCOM- 20100622
LR  - 20100201
IS  - 1526-0550 (Electronic)
IS  - 1526-0542 (Linking)
VI  - 11
IP  - 1
DP  - 2010 Mar
TI  - Update on paediatric lung transplantation.
PG  - 54-61
LID - 10.1016/j.prrv.2009.11.001 [doi]
AB  - Lung transplantation is well-established in the treatment of end-stage lung
      disease in children. Our understanding of the problems associated with
      transplantation has increased rapidly over the past 25 years. Recent figures
      suggest this knowledge is starting to translate into improvements in management
      and survival. The common indications for lung transplantation in children, the
      process of assessment and the outcomes and complications of transplantation are
      reviewed. We discuss briefly some of the ethical issues relevant to lung
      transplantation and review strategies for the future. This information may help
      the respiratory paediatrician prepare potential candidates and their families for
      the process of assessment and help him or her anticipate common problems that may
      occur.
CI  - Copyright 2009 Elsevier Ltd. All rights reserved.
FAU - Doherty, Gary M
AU  - Doherty GM
AD  - Department of Paediatric Respiratory Medicine, Kings College Hospital, Great
      Ormond Street Hospital for Children, London WC1N 3JH.
FAU - Aurora, Paul
AU  - Aurora P
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20091216
PL  - England
TA  - Paediatr Respir Rev
JT  - Paediatric respiratory reviews
JID - 100898941
SB  - IM
MH  - Child
MH  - Humans
MH  - *Lung Transplantation
MH  - Patient Selection
MH  - Referral and Consultation
RF  - 60
EDAT- 2010/02/02 06:00
MHDA- 2010/06/23 06:00
CRDT- 2010/02/02 06:00
PHST- 2010/02/02 06:00 [entrez]
PHST- 2010/02/02 06:00 [pubmed]
PHST- 2010/06/23 06:00 [medline]
AID - S1526-0542(09)00089-X [pii]
AID - 10.1016/j.prrv.2009.11.001 [doi]
PST - ppublish
SO  - Paediatr Respir Rev. 2010 Mar;11(1):54-61. doi: 10.1016/j.prrv.2009.11.001. Epub 
      2009 Dec 16.


PMID- 20113674
OWN - NLM
STAT- MEDLINE
DCOM- 20100408
LR  - 20211028
IS  - 2046-4924 (Electronic)
IS  - 1366-5278 (Linking)
VI  - 14
IP  - 5
DP  - 2010 Jan
TI  - Effectiveness and cost-effectiveness of arthroscopic lavage in the treatment of
      osteoarthritis of the knee: a mixed methods study of the feasibility of
      conducting a surgical placebo-controlled trial (the KORAL study).
PG  - 1-180
LID - 10.3310/hta14040 [doi]
AB  - OBJECTIVES: To ascertain the acceptability of a randomised controlled trial
      comparing arthroscopic lavage with a placebo-surgical procedure for the
      management of osteoarthritis of the knee; and to assess the practical feasibility
      of mounting such a multicentre placebo-controlled trial. DESIGN: Mixed methods
      study including: focus groups with surgeons and anaesthetists; focus groups and
      interviews with potential participants; interviews with chairpersons of UK
      Multicentre Research Ethics Committees (MRECs); surveys of surgeons and
      anaesthetists; and a two-centre, three-arm pilot. SETTING: UK secondary care.
      PARTICIPANTS: Members of the British Association of Surgeons of the Knee and
      members of the British Society of Orthopaedic Anaesthetists took part in the
      focus groups and surveys. Surgeons and anaesthetists from two regional centres in
      the UK also contributed to focus groups, as did patients from consultant lists in
      two UK regional centres, and members of Arthritis Care. Chairpersons of six UK
      MRECs were interviewed. Participants were eligible for the pilot if they were
      adults (18 years or older) with radiological evidence of osteoarthritis of the
      knee who might be considered for arthroscopic lavage, and were fit for general
      anaesthetic (defined by the American Society of Anaesthesiologists grades 1 and
      2), and able to give informed consent. INTERVENTIONS: Participants in the pilot
      study were randomised to arthrosocopic lavage (with or without debridement at the
      clinical discretion of the surgeon); placebo surgery; or non-operative management
      with specialist reassessment. MAIN OUTCOME MEASURES: The acceptability and
      feasibility of mounting a placebo-controlled trial for the evaluation of knee
      arthroscopic lavage. RESULTS: There was broad acceptance across all stakeholder
      groups of the need to find out more about the effectiveness of arthroscopic
      lavage. Despite this there was variation in opinion within all the groups about
      how researchers should approach this and whether or not it would be acceptable to
      investigate using placebo surgery. Within the health professional groups, there
      tended to be a split between those who were strongly opposed to the inclusion of 
      a placebo surgery arm and those who were more in favour. For prospective trial
      participants who had osteoarthritis of the knee, the acceptability of the trial
      was discussed from a more individual perspective - reflecting on their personal
      reasons for or against participating. The majority of this group said they would 
      consider taking part. The pilot study showed that, in principle, a
      placebo-controlled trial could be conducted. It showed that patients were willing
      to participate in a trial which would involve a placebo-surgical arm and that it 
      was possible to undertake placebo surgery successfully and to blind patients to
      their allocation - although once patients knew their allocation, some patients
      allocated to surgery became more concerned about the possibility of undergoing
      placebo surgery, and withdrew. The experience of the pilot, however, showed that,
      despite full MREC approval, the study required major discussion and negotiation
      before local clinical approvals could be obtained. The fact that ethics approval 
      had been granted did not mean that clinicians would automatically accept that the
      process was ethical. CONCLUSIONS: The study showed that, in principle, a
      placebo-controlled trial of arthroscopic lavage could be conducted in the UK,
      albeit with difficulty. Against the background of falling use of arthroscopic
      lavage the decision was, therefore, taken not to proceed to full-scale trial for 
      this procedure. The study showed that for some health professionals the use of
      placebo surgery can never be justified. It highlighted the importance of the
      surgeon-anaesthetist relationship in this context and how acceptance of the trial
      design by both parties is essential to successful participation. It also
      highlighted the importance of informed consent for trial participants and the
      strength and influence of individuals' ethical perspectives in addition to
      collective ethics provided by MRECs. TRIAL REGISTRATION: Current Controlled
      Trials ISRCTN02328576.
FAU - Campbell, M K
AU  - Campbell MK
AD  - Health Services Research Unit, University of Aberdeen, Aberdeen, UK.
FAU - Skea, Z C
AU  - Skea ZC
FAU - Sutherland, A G
AU  - Sutherland AG
FAU - Cuthbertson, B H
AU  - Cuthbertson BH
FAU - Entwistle, V A
AU  - Entwistle VA
FAU - McDonald, A M
AU  - McDonald AM
FAU - Norrie, J D
AU  - Norrie JD
FAU - Carlson, R V
AU  - Carlson RV
FAU - Bridgman, S
AU  - Bridgman S
CN  - KORAL study group
LA  - eng
SI  - ISRCTN/ISRCTN02328576
GR  - 03/48/01/DH_/Department of Health/United Kingdom
GR  - HERU1/CSO_/Chief Scientist Office/United Kingdom
GR  - HSRU1/CSO_/Chief Scientist Office/United Kingdom
PT  - Journal Article
PL  - England
TA  - Health Technol Assess
JT  - Health technology assessment (Winchester, England)
JID - 9706284
SB  - IM
MH  - Anesthesiology
MH  - Arthroscopy/economics/*methods
MH  - Attitude of Health Personnel
MH  - Attitude to Health
MH  - Cost-Benefit Analysis
MH  - Feasibility Studies
MH  - Focus Groups
MH  - Humans
MH  - Informed Consent
MH  - *Multicenter Studies as Topic
MH  - Needs Assessment
MH  - Orthopedics
MH  - Osteoarthritis, Knee/psychology/*surgery
MH  - Patient Selection
MH  - Pilot Projects
MH  - *Randomized Controlled Trials as Topic
MH  - Research Design
MH  - Technology Assessment, Biomedical
MH  - Therapeutic Irrigation/economics/*methods
MH  - United Kingdom
IR  - Cotton S
FIR - Cotton, Seonaidh
IR  - Donaldson A
FIR - Donaldson, Angela
IR  - Fitzpatrick R
FIR - Fitzpatrick, Ray
IR  - Grant A
FIR - Grant, Adrian
IR  - Grey A
FIR - Grey, Alastair
IR  - Hutchison J
FIR - Hutchison, James
IR  - Johnston M
FIR - Johnston, Marie
IR  - Murray D
FIR - Murray, David
IR  - Ramsay C
FIR - Ramsay, Craig
IR  - Rowley D
FIR - Rowley, David
IR  - Vale L
FIR - Vale, Luke
IR  - Wigderowitz C
FIR - Wigderowitz, Carlos
EDAT- 2010/02/02 06:00
MHDA- 2010/04/09 06:00
CRDT- 2010/02/02 06:00
PHST- 2010/02/02 06:00 [entrez]
PHST- 2010/02/02 06:00 [pubmed]
PHST- 2010/04/09 06:00 [medline]
AID - 10.3310/hta14040 [doi]
PST - ppublish
SO  - Health Technol Assess. 2010 Jan;14(5):1-180. doi: 10.3310/hta14040.


PMID- 25949400
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150507
LR  - 20220317
IS  - 1753-0784 (Print)
IS  - 1753-0784 (Linking)
VI  - 3
IP  - 1
DP  - 2010 Feb
TI  - Specific nutritional problems in acute kidney injury, treated with non-dialysis
      and dialytic modalities.
PG  - 1-7
LID - 10.1093/ndtplus/sfp017 [doi]
AB  - Patients who develop AKI, especially in the intensive care unit (ICU), are at
      risk of protein-energy malnutrition, which is a major negative prognostic factor 
      in this clinical condition. Despite the lack of evidence from controlled trials
      of its effect on outcome, nutritional support by the enteral (preferentially)
      and/or parenteral route appears clinically indicated in most cases of
      ICU-acquired AKI, independently of the actual nutritional status of the patient, 
      in order to prevent deterioration in the nutritional state with all its known
      complications. Extrapolating from data in other conditions, it seems
      intrinsically unlikely that starvation of a catabolic patient is more beneficial 
      than appropriate nutritional support by an expert team with the skills to avoid
      the potential complications of the enteral and parenteral nutrition
      methodologies. By the same token, it is ethically impossible to conduct a trial
      in which the control group undergoes prolonged starvation. The primary goals of
      nutritional support in AKI, which represents a well-known inflammatory and
      pro-oxidative condition, are the same as those for other critically ill patients 
      with normal renal function, i.e. to ensure the delivery of adequate nutrition, to
      prevent protein-energy wasting with its attendant metabolic complications, to
      promote wound healing and tissue repair, to support immune system function, to
      accelerate recovery and to reduce mortality. Patients with AKI on RRT should
      receive a basic intake of at least 1.5 g/kg/day of protein with an additional 0.2
      g/kg/day to compensate for amino acid/protein loss during RRT, especially when
      daily treatments and/or high efficiecy modalities are used. Energy intake should 
      consist of no more than 30 kcal non-protein calories or 1.3 x BEE (Basal Energy
      Expenditure) calculated by the Harris-Benedict equation, with approximately
      30-35% from lipid, as lipid emulsions. For nutritional support, the enteral route
      is preferred, although it often needs to be supplemented through the parenteral
      route in order to meet nutritional requirements.
FAU - Fiaccadori, Enrico
AU  - Fiaccadori E
AD  - Internal Medicine and Nephrology Department , Parma University Medical School ,
      Parma , Italy.
FAU - Regolisti, Giuseppe
AU  - Regolisti G
AD  - Internal Medicine and Nephrology Department , Parma University Medical School ,
      Parma , Italy.
FAU - Cabassi, Aderville
AU  - Cabassi A
AD  - Internal Medicine and Nephrology Department , Parma University Medical School ,
      Parma , Italy.
LA  - eng
PT  - Journal Article
DEP - 20090211
PL  - England
TA  - NDT Plus
JT  - NDT plus
JID - 101472665
PMC - PMC4421537
OTO - NOTNLM
OT  - acute kidney injury
OT  - catabolism
OT  - dialysis
OT  - enteral nutrition
OT  - parenteral nutrition
EDAT- 2010/02/01 00:00
MHDA- 2010/02/01 00:01
CRDT- 2015/05/08 06:00
PHST- 2008/11/01 00:00 [received]
PHST- 2009/01/21 00:00 [accepted]
PHST- 2015/05/08 06:00 [entrez]
PHST- 2010/02/01 00:00 [pubmed]
PHST- 2010/02/01 00:01 [medline]
AID - 10.1093/ndtplus/sfp017 [doi]
AID - sfp017 [pii]
PST - ppublish
SO  - NDT Plus. 2010 Feb;3(1):1-7. doi: 10.1093/ndtplus/sfp017. Epub 2009 Feb 11.


PMID- 24683249
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140513
LR  - 20211021
IS  - 0011-393X (Print)
IS  - 0011-393X (Linking)
VI  - 71
IP  - 1
DP  - 2010 Feb
TI  - The reporting quality, scientific rigor, and ethics of randomized
      placebo-controlled trials of traditional Chinese medicine compound formulations
      and the differences between Chinese and non-Chinese trials.
PG  - 30-49
LID - 10.1016/j.curtheres.2010.02.001 [doi]
AB  - BACKGROUND: An increasing number of randomized placebo-controlled trials
      involving traditional Chinese medicine (TCM) compound formulations have been
      implemented worldwide. OBJECTIVE: The aim of this study was to assess the
      reporting quality, scientific rigor, and ethics of randomized placebo-controlled 
      trials of TCM compound formulations and compare these differences between Chinese
      and non-Chinese trials. METHODS: English-language databases included the
      following: PubMed, OVID, EMBASE, and Science Citation Index Expanded.
      Chinese-language databases included the following: Chinese Biomedical Literature 
      Database, Wanfang Database, Chinese Scientific and Technological Periodical
      Database, and the China National Knowledge Infrastructure. All were searched from
      respective inception to March 2009 to identify randomized placebo-controlled
      trials involving TCM compound prescriptions. Two reviewers independently assessed
      the retrieved trials via a modified Consolidated Standard of Reporting Trials
      (CONSORT) checklist and some evaluation indices that embodied the TCM
      characteristics or the scientific rigor and ethics of placebo-controlled trials. 
      Trial publishing time was divided into 3 intervals: phase 1 (</=1999); phase 2
      (2000-2004); and phase 3 (2005-2009). The number and percentage of trials
      reporting each item and the corresponding differences between Chinese (mainland
      China, Hong Kong, and Taiwan) and non-Chinese (eg, Japan, United States,
      Australia, Korea, and United Kingdom) trials were calculated. Moreover, the
      influence of trial publishing time on the reporting of CONSORT items and the
      differences in the number of items reported for each time interval between
      Chinese and non-Chinese trials were assessed. RESULTS: A total of 324 trials from
      China and 51 trials from other countries were included. A mean of 39.7% of the
      CONSORT items across all Chinese trials and 50.2% of the items across all
      non-Chinese trials were reported. The number of the reported CONSORT items all
      increased over time in both groups and the gap between Chinese articles and
      non-Chinese articles gradually decreased. Additionally, of the 324 Chinese
      articles, 137 (42.28%) reported TCM syndrome type, 113 (34.88%) reported the
      diagnostic criteria of diseases for TCM, and 69 (21.30%) reported efficacy
      evaluation indices of TCM. Of the non-Chinese articles, 3 (5.88%) reported TCM
      syndrome type and 1 (1.96%) reported the diagnostic criteria of diseases and
      evaluation indices of efficacy for TCM. It was found that 45.37% and 6.17% of
      Chinese articles reported the standard intervention for the diseases being
      treated and the emergency plan, respectively, compared with 23.53% and 9.80% for 
      the non-Chinese articles; 33.02% and 10.49% of Chinese articles reported informed
      consent and ethics committee approval, respectively, compared with 92.16% and
      82.35% for the non-Chinese articles. With regard to placebo ethics, 38.89% of the
      Chinese trials and 23.53% of the non-Chinese trials found it would not be
      ethically acceptable to use placebo alone in the control group. CONCLUSIONS: The 
      data indicate that the reporting quality of the included trials on TCM compounds 
      has improved over time, but still remains poor regardless of Chinese or
      non-Chinese trials. Across all trials, particularly Chinese trials, the reporting
      of the CONSORT items was inadequate (39.7%). The difference in the mean number of
      the reported CONSORT items between Chinese trials and non-Chinese trials narrowed
      from phase 1 (10.0 vs 13.8) to phase 3 (14.4 vs 17.4). Moreover, a large number
      of trials, especially non-Chinese trials (94.1%), were lacking syndrome
      differentiation of TCM. More importantly, in many placebo-controlled trials,
      especially Chinese trials, the use of placebo was not justified and was ethically
      contradictory.
FAU - Zhong, Yun-Qing
AU  - Zhong YQ
AD  - Department of Integrated Traditional Chinese and Western Medicine, West China
      Hospital, Sichuan University, Chengdu, People's Republic of China.
FAU - Fu, Juan-Juan
AU  - Fu JJ
AD  - Department of Integrated Traditional Chinese and Western Medicine, West China
      Hospital, Sichuan University, Chengdu, People's Republic of China.
FAU - Liu, Xue-Mei
AU  - Liu XM
AD  - Chinese Evidence-Based Medicine/Cochrane Center, West China Hospital, Sichuan
      University, Chengdu, People's Republic of China.
FAU - Diao, Xiang
AU  - Diao X
AD  - Chinese Evidence-Based Medicine/Cochrane Center, West China Hospital, Sichuan
      University, Chengdu, People's Republic of China.
FAU - Mao, Bing
AU  - Mao B
AD  - Department of Integrated Traditional Chinese and Western Medicine, West China
      Hospital, Sichuan University, Chengdu, People's Republic of China.
FAU - Fan, Tao
AU  - Fan T
AD  - Department of Respiratory Medicine, West China Hospital, Sichuan University,
      Chengdu, People's Republic of China.
FAU - Yang, Hong-Mei
AU  - Yang HM
AD  - Department of Integrated Traditional Chinese and Western Medicine, West China
      Hospital, Sichuan University, Chengdu, People's Republic of China.
FAU - Liu, Guan-Jian
AU  - Liu GJ
AD  - Chinese Evidence-Based Medicine/Cochrane Center, West China Hospital, Sichuan
      University, Chengdu, People's Republic of China.
FAU - Zhang, Wen-Bin
AU  - Zhang WB
AD  - Department of Integrated Traditional Chinese and Western Medicine, West China
      Hospital, Sichuan University, Chengdu, People's Republic of China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Curr Ther Res Clin Exp
JT  - Current therapeutic research, clinical and experimental
JID - 0372621
PMC - PMC3967323
OTO - NOTNLM
OT  - CONSORT statement
OT  - ethics
OT  - placebo
OT  - randomized controlled trial
OT  - reporting quality
OT  - scientific rigor
OT  - traditional Chinese medicine compound formulation
EDAT- 2010/02/01 00:00
MHDA- 2010/02/01 00:01
CRDT- 2014/04/01 06:00
PHST- 2010/01/04 00:00 [accepted]
PHST- 2014/04/01 06:00 [entrez]
PHST- 2010/02/01 00:00 [pubmed]
PHST- 2010/02/01 00:01 [medline]
AID - 10.1016/j.curtheres.2010.02.001 [doi]
AID - S0011-393X(10)00003-2 [pii]
PST - ppublish
SO  - Curr Ther Res Clin Exp. 2010 Feb;71(1):30-49. doi:
      10.1016/j.curtheres.2010.02.001.


PMID- 22810186
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20120719
IS  - 1080-2371 (Print)
IS  - 1080-2371 (Linking)
VI  - 16
IP  - 1 Movement Disorders
DP  - 2010 Feb
TI  - Ethical perspectives in neurology.
PG  - 166-9
LID - 10.1212/01.CON.0000368201.81890.34 [doi]
FAU - Haberfeld, Elizabeth
AU  - Haberfeld E
FAU - Williams, Michael A
AU  - Williams MA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Continuum (Minneap Minn)
JT  - Continuum (Minneapolis, Minn.)
JID - 9509333
EDAT- 2010/02/01 00:00
MHDA- 2010/02/01 00:01
CRDT- 2012/07/20 06:00
PHST- 2012/07/20 06:00 [entrez]
PHST- 2010/02/01 00:00 [pubmed]
PHST- 2010/02/01 00:01 [medline]
AID - 10.1212/01.CON.0000368201.81890.34 [doi]
AID - 00132979-201002000-00010 [pii]
PST - ppublish
SO  - Continuum (Minneap Minn). 2010 Feb;16(1 Movement Disorders):166-9. doi:
      10.1212/01.CON.0000368201.81890.34.


PMID- 22043850
OWN - NLM
STAT- MEDLINE
DCOM- 20120404
LR  - 20161125
IS  - 1464-066X (Electronic)
IS  - 0020-7594 (Linking)
VI  - 45
IP  - 1
DP  - 2010 Feb
TI  - Emotional and behavioural reactions to moral transgressions: cross-cultural and
      individual variations in India and Britain.
PG  - 64-71
LID - 10.1080/00207590902913434 [doi]
AB  - Reactions to moral transgressions are subject to influence at both the cultural
      and individual levels. Transgressions against an individual's rights or against
      social conventions of hierarchy may elicit different reactions in individualistic
      and collectivistic cultures. In the current study, affective and behavioural
      reactions to transgressions of autonomy (rights) and community (hierarchy) were
      examined in India and Britain. Results revealed that although reactions to
      autonomy transgressions are similar in India and Britain, Indian participants
      express more moral outrage than do Britons in response to transgressions of
      community. Results also supported the contention of emotion-specificity in
      affective moral reaction: Participants in both India and Britain reported anger
      in response to autonomy transgressions, but contempt in response to violations of
      community. Importantly, these results extend previous research by demonstrating
      the importance of emotion specificity in moral reactions, as opposed to
      categorization or dilemma resolution. In addition, an individual difference
      measure of respect for persons was shown to moderate reactions to moral
      transgressions. Specifically, participants with high respect for persons were
      less negative to violators of the community ethic, but not the autonomy ethic.
      These findings highlight the importance of examining emotion-specific responses
      in the moral domain and introduce a significant individual difference variable,
      respect for persons, into the psychology of morality. Les reactions aux
      transgressions morales sont susceptibles d'influence a la fois aux niveaux
      culturel et individuel. Les transgressions contre les droits d'un individu ou
      contre les conventions sociales d'hierarchie peuvent susciter de differentes
      reactions dans les cultures individualiste et collectiviste. Dans la presente
      etude, les reactions affective et comportementale aux transgressions de
      l'autonomie (droits) et de la communaute (hierachie) ont ete examinees en Inde et
      en Grande-Bretagne. Les resultats ont indique que, malgre la similitude des
      reactions aux transgressions de l'autonomie en Inde et en Grande-Bretagne, les
      participants indiens ont exprime plus d'indignation morale que les britanniques
      en reponse aux transgressions de la communaute. Les resultats ont egalement
      appuye la controverse de la specifite de l'emotion dans la relation morale
      affective: les participants a la fois en Inde et en Grande-Bretagne ont rapporte 
      de la colere en reponse aux transgressions de l'autonomie mais du mepris en
      reponse aux transgressions de la communaute. De facon importante, ces resultats
      ont elargi la recherche passee en demontrant l'importance de la specificite de
      l'emotion dans les reactions morales, contrairement a la categorisation ou a la
      solution du dilemme. En plus, il a ete demontre qu'une mesure des differences
      individuelles du respect envers les personnes a modere les reactions aux
      transgressions morales. Specifiquement, les participants ayant un grand respect
      envers les personnes ont ete moins negatifs envers les violateurs de l'ethique de
      la communaute mais pas de l'ethique de l'autonomie. Ces resultats soulignent
      l'importance d'examiner les reponses specifique a l'emotion dans le domaine moral
      et introduisent une variable des differences individuelles, soit le respect
      envers les personnes, dans la psychologie de la moralite. Las reacciones a las
      transgresiones morales estan sujetas a la influencia a niveles culturales e
      individuales. Las transgresiones contra los derechos individuales o convenciones 
      sociales de jerarquias pueden provocar distintas reacciones en las culturas
      individualistas y colectivistas. En el presente estudio, se examinaron las
      reacciones afectivas y conductuales a las transgresiones contra la autonomia
      (derechos) y comunidad (jerarquia) en la India y en Gran Bretana. Los resultados 
      demostraron que, aunque las reacciones a las transgresiones contra la autonomia
      fueran parecidas en la India y en Gran Bretana, los participantes indios
      expresaron mas indignacion moral que los britanicos en la respuesta a la
      transgresion contra la comunidad. Los resultados tambien apoyan la vision de la
      especificidad emocional en la reaccion afectiva moral: los participantes en la
      India y tambien en Gran Bretana mostraron ira en respuesta a la transgresion
      contra la autonomia y desprecio en respuesta a la violacion de la comunidad. De
      forma importante, estos resultados amplian los estudios anteriores demostrando la
      importancia de la especificidad emocional en las reacciones morales frente a la
      categorizacion o resolucion de los dilemas. Adicionalmente, las medidas de las
      diferencias individuales en el respeto para personas moderan las reacciones a la 
      transgresion moral. Especificamente, los participantes con alto respeto para
      personas fueron menos negativos a la hora de violar la etica de la comunidad pero
      no la etica de la autonomia. Estos resultados subrayan la importancia de estudiar
      las respuestas emocionales especificas en el dominio moral e introducen una
      variable de diferencias individuales significativas, respeto para personas,
      dentro de la psicologia de la moralidad.
FAU - Laham, Simon M
AU  - Laham SM
AD  - University of Melbourne, Australia. slaham@unimelb.edu.au
FAU - Chopra, Sonavi
AU  - Chopra S
FAU - Lalljee, Mansur
AU  - Lalljee M
FAU - Parkinson, Brian
AU  - Parkinson B
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Psychol
JT  - International journal of psychology : Journal international de psychologie
JID - 0107305
SB  - IM
MH  - Anger
MH  - *Cross-Cultural Comparison
MH  - *Emotions
MH  - Female
MH  - Humans
MH  - India
MH  - *Individuality
MH  - Male
MH  - *Morals
MH  - Personal Autonomy
MH  - Residence Characteristics
MH  - *Social Behavior
MH  - Social Identification
MH  - Social Values
MH  - Students/psychology
MH  - United Kingdom
MH  - Young Adult
EDAT- 2010/02/01 00:00
MHDA- 2012/04/05 06:00
CRDT- 2011/11/03 06:00
PHST- 2011/11/03 06:00 [entrez]
PHST- 2010/02/01 00:00 [pubmed]
PHST- 2012/04/05 06:00 [medline]
AID - 10.1080/00207590902913434 [doi]
PST - ppublish
SO  - Int J Psychol. 2010 Feb;45(1):64-71. doi: 10.1080/00207590902913434.


PMID- 20112210
OWN - NLM
STAT- MEDLINE
DCOM- 20100415
LR  - 20191210
IS  - 1012-5302 (Print)
IS  - 1012-5302 (Linking)
VI  - 23
IP  - 1
DP  - 2010 Feb
TI  - [Cura sui--selfcare and its relationship to nursing].
PG  - 37-43
LID - 10.1024/1012-5302/a000007 [doi]
AB  - Self care is an answer to the response of finiteness, which is given through the 
      fact of the human body. The article demonstrates in reference to the
      Selfcaredeficit-Theory (Orem, 2006) how self care in everyday life, ancient roman
      called it cura sui, is related to nursing practice, specially to acutecare. Self 
      care turns out as an category of ambivalence between ethics and power.
FAU - Schnell, Martin W
AU  - Schnell MW
AD  - Institut fur Pflegewissenschaft und Institut fur Ethik und Kommunikation im
      Gesundheitswesen, Private Universitat Witten/Herdecke, Stockumer Strasse 12,
      D-58543 Witten. Schnell@uni-wh.de
LA  - ger
PT  - Journal Article
PT  - Review
TT  - CURA SUI - Die Selbstsorge und ihre Beziehung zur Pflege.
PL  - Switzerland
TA  - Pflege
JT  - Pflege
JID - 8907069
MH  - *Adaptation, Psychological/ethics
MH  - Caregivers/*psychology
MH  - Ethics, Nursing
MH  - Humans
MH  - *Models, Nursing
MH  - *Nursing Assessment/ethics
MH  - Power, Psychological
RF  - 29
EDAT- 2010/01/30 06:00
MHDA- 2010/04/16 06:00
CRDT- 2010/01/30 06:00
PHST- 2010/01/30 06:00 [entrez]
PHST- 2010/01/30 06:00 [pubmed]
PHST- 2010/04/16 06:00 [medline]
AID - 10.1024/1012-5302/a000007 [doi]
PST - ppublish
SO  - Pflege. 2010 Feb;23(1):37-43. doi: 10.1024/1012-5302/a000007.


PMID- 20112079
OWN - NLM
STAT- MEDLINE
DCOM- 20101103
LR  - 20181201
IS  - 1496-8975 (Electronic)
IS  - 0832-610X (Linking)
VI  - 57
IP  - 4
DP  - 2010 Apr
TI  - Cardiopulmonary bypass does not affect plasma concentration of preoperatively
      administered gabapentin.
PG  - 337-42
LID - 10.1007/s12630-010-9269-5 [doi]
AB  - PURPOSE: Drug effects can be unpredictable during cardiac surgery due to factors 
      that may influence drug concentration, such as extracorporeal oxygenation and
      hemodilution. The primary aim of the current investigation was to determine
      whether plasma gabapentin concentration is altered by cardiopulmonary bypass
      (CPB). METHODS: Following approval from the Research Ethics Board and written
      informed consent, we conducted this open-label prospective cohort investigation. 
      A convenience sample of 16 patients, who were scheduled for coronary bypass
      surgery, received oral gabapentin 600 mg as follows: 90 min prior to induction of
      anesthesia, following tracheal extubation, and then every eight hours for a total
      of four doses. Plasma gabapentin concentration, as well as pain and sedation
      scores, were documented. RESULTS: Plasma gabapentin concentrations were unaltered
      during CPB (31.9 +/- 12.7 mumol.L(-1) prior to CPB, 35.6 +/- 12.9 to 37.2 +/- 9.6
      mumol.L(-1) during CPB). However, using the current protocol, drug accumulation
      (reflected by increased drug concentrations) was observed following the third
      (58.2 +/- 19.5 micromol.L(-1)) and the fourth (71.9 +/- 34.3 micromol.L(-1))
      doses. Pain and sedation scores and opioid requirements were comparable with
      those found in other studies. CONCLUSION: Plasma gabapentin concentration is
      unaltered during CPB following preoperative administration. Drug accumulation
      following third and fourth postoperative doses suggests the need for therapeutic 
      drug monitoring in future trials. Gabapentin is well established as an effective 
      adjunct analgesic in a number of surgical settings. Randomized controlled trials 
      are necessary to evaluate analgesic efficacy, optimal dosing, and adverse effects
      in the setting of cardiac surgery.
FAU - Parlow, Joel
AU  - Parlow J
AD  - Department of Anesthesiology & Perioperative Medicine, Queen's University &
      Kingston General Hospital, 76 Stuart Street, Kingston, Ontario, Canada.
      parlowj@queensu.ca
FAU - Gilron, Ian
AU  - Gilron I
FAU - Milne, Brian
AU  - Milne B
FAU - Dumerton-Shore, Deborah
AU  - Dumerton-Shore D
FAU - Orr, Elizabeth
AU  - Orr E
FAU - Phelan, Rachel
AU  - Phelan R
LA  - eng
SI  - ClinicalTrials.gov/NCT01022736
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100129
PL  - United States
TA  - Can J Anaesth
JT  - Canadian journal of anaesthesia = Journal canadien d'anesthesie
JID - 8701709
RN  - 0 (Amines)
RN  - 0 (Analgesics)
RN  - 0 (Cyclohexanecarboxylic Acids)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - 6CW7F3G59X (Gabapentin)
SB  - IM
MH  - Aged
MH  - Amines/administration & dosage/*blood
MH  - Analgesics/administration & dosage/*blood
MH  - Cardiopulmonary Bypass/*adverse effects
MH  - Cohort Studies
MH  - Cyclohexanecarboxylic Acids/administration & dosage/*blood
MH  - Dose-Response Relationship, Drug
MH  - Drug Monitoring
MH  - Female
MH  - Gabapentin
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pain Measurement
MH  - Preoperative Care
MH  - Time Factors
MH  - Treatment Outcome
MH  - gamma-Aminobutyric Acid/administration & dosage/*blood
EDAT- 2010/01/30 06:00
MHDA- 2010/11/04 06:00
CRDT- 2010/01/30 06:00
PHST- 2009/10/06 00:00 [received]
PHST- 2010/01/12 00:00 [accepted]
PHST- 2010/01/30 06:00 [entrez]
PHST- 2010/01/30 06:00 [pubmed]
PHST- 2010/11/04 06:00 [medline]
AID - 10.1007/s12630-010-9269-5 [doi]
PST - ppublish
SO  - Can J Anaesth. 2010 Apr;57(4):337-42. doi: 10.1007/s12630-010-9269-5. Epub 2010
      Jan 29.


PMID- 20109972
OWN - NLM
STAT- MEDLINE
DCOM- 20100422
LR  - 20211028
IS  - 1558-075X (Electronic)
IS  - 0146-0005 (Linking)
VI  - 34
IP  - 1
DP  - 2010 Feb
TI  - Noninvasive cerebral perfusion imaging in high-risk neonates.
PG  - 46-56
LID - 10.1053/j.semperi.2009.10.005 [doi]
AB  - Advances in medical and surgical care of the high-risk neonate have led to
      increased survival. A significant number of these neonates suffer from
      neurodevelopmental delays and failure in school. The focus of clinical research
      has shifted to understanding events contributing to neurological morbidity in
      these patients. Assessing changes in cerebral oxygenation and regulation of
      cerebral blood flow (CBF) is important in evaluating the status of the central
      nervous system. Traditional CBF imaging methods fail for both ethical and
      logistical reasons. Optical near infrared spectroscopy (NIRS) is increasingly
      being used for bedside monitoring of cerebral oxygenation and blood volume in
      both very low birth weight infants and neonates with congenital heart disease.
      Although trends in CBF may be inferred from changes in cerebral oxygenation
      and/or blood volume, NIRS does not allow a direct measure of CBF in these
      populations. Two relatively new modalities, arterial spin-labeled perfusion
      magnetic resonance imaging and optical diffuse correlation spectroscopy, provide 
      direct, noninvasive measures of cerebral perfusion suitable for the high-risk
      neonates. Herein we discuss the instrumentation, applications, and limitations of
      these noninvasive imaging techniques for measuring and/or monitoring CBF.
CI  - (c) 2010 Elsevier Inc. All rights reserved.
FAU - Goff, Donna A
AU  - Goff DA
AD  - Department of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA
      19104, USA.
FAU - Buckley, Erin M
AU  - Buckley EM
FAU - Durduran, Turgut
AU  - Durduran T
FAU - Wang, Jiongjong
AU  - Wang J
FAU - Licht, Daniel J
AU  - Licht DJ
LA  - eng
GR  - R01 NS072338/NS/NINDS NIH HHS/United States
GR  - R01 MH080892/MH/NIMH NIH HHS/United States
GR  - Z01 NR000016/ImNIH/Intramural NIH HHS/United States
GR  - T32 HL007915/HL/NHLBI NIH HHS/United States
GR  - K-23 NS-052380/NS/NINDS NIH HHS/United States
GR  - K23 NS052380-01/NS/NINDS NIH HHS/United States
GR  - K23 NS052380-05/NS/NINDS NIH HHS/United States
GR  - P41 RR002305/RR/NCRR NIH HHS/United States
GR  - K23 NS052380/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Semin Perinatol
JT  - Seminars in perinatology
JID - 7801132
RN  - 0 (Spin Labels)
SB  - IM
MH  - Cerebrovascular Circulation/*physiology
MH  - Erythrocytes/physiology
MH  - Humans
MH  - Infant, Newborn
MH  - Magnetic Resonance Imaging/*methods/standards
MH  - Spectroscopy, Near-Infrared/*methods/standards
MH  - Spin Labels
RF  - 110
PMC - PMC2829712
MID - NIHMS174063
EDAT- 2010/01/30 06:00
MHDA- 2010/04/23 06:00
CRDT- 2010/01/30 06:00
PHST- 2010/01/30 06:00 [entrez]
PHST- 2010/01/30 06:00 [pubmed]
PHST- 2010/04/23 06:00 [medline]
AID - S0146-0005(09)00093-7 [pii]
AID - 10.1053/j.semperi.2009.10.005 [doi]
PST - ppublish
SO  - Semin Perinatol. 2010 Feb;34(1):46-56. doi: 10.1053/j.semperi.2009.10.005.


PMID- 20109960
OWN - NLM
STAT- MEDLINE
DCOM- 20100217
LR  - 20150616
IS  - 1474-547X (Electronic)
IS  - 0140-6736 (Linking)
VI  - 375
IP  - 9711
DP  - 2010 Jan 23
TI  - Responsibility for protection of medical workers and facilities in armed
      conflict.
PG  - 329-40
LID - 10.1016/S0140-6736(09)61926-7 [doi]
AB  - Assaults on patients and medical personnel, facilities, and transports, denial of
      access to medical services, and misuse of medical facilities and emblems have
      become a feature of armed conflict despite their prohibition by the laws of war. 
      Strategies to improve compliance with these laws, protection, and accountability 
      are lacking, and regular reporting of violations is absent. A systematic review
      of the frequency of reporting and types of violations has not been done for more 
      than 15 years. To gain a better understanding of the scope and extent of the
      problem, we used uniform search criteria to review three global sources of human 
      rights reports in armed conflicts for 2003-08, and in-depth reports on violations
      committed in armed conflict during 1989-2008. Findings from this review showed
      deficiencies in the extent and methods of reporting, but also identified three
      major trends in such assaults: attacks on medical functions seem to be part of a 
      broad assault on civilians; assaults on medical functions are used to achieve a
      military advantage; and combatants do not respect the ethical duty of health
      professionals to provide care to patients irrespective of affiliation. WHO needs 
      to lead robust and systematic documentation of these violations, and countries
      and the medical community need to take steps to improve compliance, protection,
      and accountability.
CI  - Copyright 2010 Elsevier Ltd. All rights reserved.
FAU - Rubenstein, Leonard S
AU  - Rubenstein LS
AD  - Johns Hopkins Bloomberg School of Public Health, John Hopkins University,
      Baltimore, MD 21205, USA. lrubenst@jhsph.edu
FAU - Bittle, Melanie D
AU  - Bittle MD
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - Lancet
JT  - Lancet (London, England)
JID - 2985213R
SB  - IM
CIN - Lancet. 2010 Mar 13;375(9718):894. PMID: 20226986
CIN - Lancet. 2010 Mar 13;375(9718):894. PMID: 20226987
MH  - *Health Facilities
MH  - *Health Personnel
MH  - *Human Rights Abuses
MH  - Humans
MH  - Internationality
MH  - *War Crimes/legislation & jurisprudence
EDAT- 2010/01/30 06:00
MHDA- 2010/02/18 06:00
CRDT- 2010/01/30 06:00
PHST- 2010/01/30 06:00 [entrez]
PHST- 2010/01/30 06:00 [pubmed]
PHST- 2010/02/18 06:00 [medline]
AID - S0140-6736(09)61926-7 [pii]
AID - 10.1016/S0140-6736(09)61926-7 [doi]
PST - ppublish
SO  - Lancet. 2010 Jan 23;375(9711):329-40. doi: 10.1016/S0140-6736(09)61926-7.


PMID- 20109513
OWN - NLM
STAT- MEDLINE
DCOM- 20100602
LR  - 20131121
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 48
IP  - 3
DP  - 2010 Mar
TI  - Hookah (shisha, narghile, "water pipe") indoor air contamination in German
      unrealistic experiment. Serious methodological biases and ethical concern.
PG  - 992-5; author reply 996-7
LID - 10.1016/j.fct.2010.01.020 [doi]
FAU - Chaouachi, Kamal
AU  - Chaouachi K
LA  - eng
PT  - Comment
PT  - Letter
DEP - 20100128
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Tobacco Smoke Pollution)
RN  - 059QF0KO0R (Water)
RN  - 16291-96-6 (Charcoal)
SB  - IM
CON - Food Chem Toxicol. 2009 Jul;47(7):1636-41. PMID: 19394392
CIN - Food Chem Toxicol. 2010 Mar;48(3):771. PMID: 20102731
MH  - Air Pollution, Indoor/*analysis
MH  - Charcoal/chemistry
MH  - *Ethics, Research
MH  - Humans
MH  - Publication Bias
MH  - *Research Design
MH  - Social Environment
MH  - Tobacco/chemistry
MH  - Tobacco Smoke Pollution/*analysis
MH  - Ventilation
MH  - Water/chemistry
EDAT- 2010/01/30 06:00
MHDA- 2010/06/03 06:00
CRDT- 2010/01/30 06:00
PHST- 2010/01/30 06:00 [entrez]
PHST- 2010/01/30 06:00 [pubmed]
PHST- 2010/06/03 06:00 [medline]
AID - S0278-6915(10)00072-4 [pii]
AID - 10.1016/j.fct.2010.01.020 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2010 Mar;48(3):992-5; author reply 996-7. doi:
      10.1016/j.fct.2010.01.020. Epub 2010 Jan 28.


PMID- 20108996
OWN - NLM
STAT- MEDLINE
DCOM- 20100413
LR  - 20151119
IS  - 1445-6354 (Electronic)
IS  - 1445-6354 (Linking)
VI  - 10
IP  - 1
DP  - 2010 Jan-Mar
TI  - Reaching agreement for an Aboriginal e-health research agenda: the Aboriginal
      Telehealth Knowledge Circle consensus method.
PG  - 1299
AB  - INTRODUCTION: In Canada, telehealth has been successfully implemented in a number
      of Aboriginal communities with subsequent improvements to access to health care
      and quality of life. However, there are many knowledge gaps that limit our
      understanding of the broad range of Aboriginal e-health issues; a research agenda
      is urgently required. The objective of this research was to develop an Aboriginal
      e-health research agenda designed to address the substantial knowledge gaps that 
      impede e-health deployment and adoption particularly in rural and remote
      Aboriginal communities in Canada. A consensus method based on Aboriginal culture,
      values and approaches to consensus was developed to achieve this. METHODS: In
      this consensus methodology, a core group of Aboriginal telehealth leaders, led by
      a research facilitator, engaged in an iterative process of individual and group
      review of research data. The reviewed data included stakeholder interview data,
      questionnaires, literature and other resources and was prioritized in order to
      develop recommendations for an Aboriginal e-health research agenda. RESULTS: A
      total of 40 stakeholders including Aboriginal Telehealth Knowledge Circle (ATKC) 
      members, communities of practice and regional, provincial and federal leaders and
      policy-makers participated in the consensus process. The research recommendations
      showed a high degree of consistency among stakeholders. Participants reached
      consensus on 6 areas: research ethics, internet-based e-health services data,
      educational resources, sustainability models, best practices and exploration of
      innovative applications. CONCLUSIONS: An ATKC consensus process was successfully 
      applied to reach consensus on an Aboriginal e-health research agenda,
      demonstrating the potential of Indigenous research approaches for defining levels
      of agreement on complex topics. The resulting conceptual map for e-health
      research can be used as a springboard for partnership-based research initiatives 
      involving Aboriginal communities, governments and researchers, and may be of
      interest to Indigenous e-health researchers at an international level.
FAU - Maar, M A
AU  - Maar MA
AD  - Northern Ontario School of Medicine, Ontario, Canada. marion.maar@normed.ca
FAU - Seymour, A
AU  - Seymour A
FAU - Sanderson, B
AU  - Sanderson B
FAU - Boesch, L
AU  - Boesch L
LA  - eng
PT  - Journal Article
DEP - 20100127
PL  - Australia
TA  - Rural Remote Health
JT  - Rural and remote health
JID - 101174860
SB  - IM
MH  - Canada
MH  - *Consensus
MH  - Consumer Health Information/*organization & administration
MH  - Diffusion of Innovation
MH  - Ethics, Research
MH  - *Goals
MH  - Humans
MH  - *Internet
MH  - *Population Groups
MH  - *Research Design
MH  - Surveys and Questionnaires
MH  - *Telemedicine
EDAT- 2010/01/30 06:00
MHDA- 2010/04/14 06:00
CRDT- 2010/01/30 06:00
PHST- 2010/01/30 06:00 [entrez]
PHST- 2010/01/30 06:00 [pubmed]
PHST- 2010/04/14 06:00 [medline]
AID - 1299 [pii]
PST - ppublish
SO  - Rural Remote Health. 2010 Jan-Mar;10(1):1299. Epub 2010 Jan 27.


PMID- 20108639
OWN - NLM
STAT- MEDLINE
DCOM- 20100317
LR  - 20100517
IS  - 0882-1577 (Print)
IS  - 0882-1577 (Linking)
VI  - 91
IP  - 1
DP  - 2010 Jan-Feb
TI  - Thinking ethically about emergency contraception. Critical judgments require
      adequate and accurate information.
PG  - 62-7
FAU - Hamel, Ron
AU  - Hamel R
AD  - Catholic Health Association, St. Louis, USA. rhamel@chausa.org
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Health Prog
JT  - Health progress (Saint Louis, Mo.)
JID - 8500263
CIN - Health Prog. 2010 May-Jun;91(3):64; author reply 65. PMID: 20469831
MH  - Contraception, Postcoital/*ethics
MH  - Humans
MH  - Judgment/*ethics
MH  - Religion and Sex
MH  - United States
EDAT- 2010/01/30 06:00
MHDA- 2010/03/18 06:00
CRDT- 2010/01/30 06:00
PHST- 2010/01/30 06:00 [entrez]
PHST- 2010/01/30 06:00 [pubmed]
PHST- 2010/03/18 06:00 [medline]
PST - ppublish
SO  - Health Prog. 2010 Jan-Feb;91(1):62-7.


PMID- 20108593
OWN - NLM
STAT- MEDLINE
DCOM- 20100303
LR  - 20100129
IS  - 0883-5381 (Print)
IS  - 0883-5381 (Linking)
VI  - 25
IP  - 1
DP  - 2010 Jan-Feb
TI  - The ethics of evidence-based management. Best practices will produce better
      outcomes for all healthcare stakeholders.
PG  - 48, 50-1
FAU - Hofmann, Paul B
AU  - Hofmann PB
AD  - Hofmann Healthcare Group, Moraga, CA 94556, USA. hofmann@hofmannhealth.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Healthc Exec
JT  - Healthcare executive
JID - 8612808
MH  - *Efficiency, Organizational
MH  - Evidence-Based Practice/*ethics
MH  - *Hospital Administration
MH  - United States
EDAT- 2010/01/30 06:00
MHDA- 2010/03/04 06:00
CRDT- 2010/01/30 06:00
PHST- 2010/01/30 06:00 [entrez]
PHST- 2010/01/30 06:00 [pubmed]
PHST- 2010/03/04 06:00 [medline]
PST - ppublish
SO  - Healthc Exec. 2010 Jan-Feb;25(1):48, 50-1.


PMID- 20108591
OWN - NLM
STAT- MEDLINE
DCOM- 20100303
LR  - 20100129
IS  - 0883-5381 (Print)
IS  - 0883-5381 (Linking)
VI  - 25
IP  - 1
DP  - 2010 Jan-Feb
TI  - Creating a culture of accountability. Ethics is the key to sharing healthcare
      stewardship.
PG  - 30-2, 34, 36
FAU - Freund, Lisa M
AU  - Freund LM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Healthc Exec
JT  - Healthcare executive
JID - 8612808
MH  - Health Facility Administrators/*ethics
MH  - Humans
MH  - *Organizational Culture
MH  - *Social Responsibility
MH  - United States
EDAT- 2010/01/30 06:00
MHDA- 2010/03/04 06:00
CRDT- 2010/01/30 06:00
PHST- 2010/01/30 06:00 [entrez]
PHST- 2010/01/30 06:00 [pubmed]
PHST- 2010/03/04 06:00 [medline]
PST - ppublish
SO  - Healthc Exec. 2010 Jan-Feb;25(1):30-2, 34, 36.


PMID- 20108051
OWN - NLM
STAT- MEDLINE
DCOM- 20120209
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 17
IP  - 2
DP  - 2011 Jun
TI  - A professor's moral thinking at the abstract level versus the professor's moral
      thinking in the real life situation (consistency problem).
PG  - 299-320
LID - 10.1007/s11948-009-9190-x [doi]
AB  - We conducted an on-line survey to investigate the professor's idea of "morality" 
      and then to compare their moral thinking at the abstract level with their moral
      thinking in the real life situations by sampling 257 professors from the
      University of Novi Sad. We constructed questionnaire based on related theoretical
      ethical concepts. Our results show (after we performed exploratory factor
      analysis) that the professor's idea of "morality" consists of the three moral
      thinking patterns which are simultaneously activated during the process of their 
      abstract moral thinking. We have identified these patterns in the following
      manner: deontological, formal and subjective pattern. In addition, our results
      show that of the three, the subjective pattern is more activated than the other
      two during their process of the moral thinking at the abstract level. We also
      discovered that there is a statistically significant difference between
      professor's moral thinking patterns activation level at the abstract level and
      their moral thinking patterns activation level in the real life situation.
FAU - Pecujlija, Mladen
AU  - Pecujlija M
AD  - Faculty of Technical Sciences, Trg Dositeja Obradovica 6, 21000, Novi Sad,
      Serbia. pecujlija@gmail.com
FAU - Cosic, Ilija
AU  - Cosic I
FAU - Ivanisevic, Velibor
AU  - Ivanisevic V
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20100127
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Data Collection
MH  - *Ethical Analysis
MH  - *Ethical Theory
MH  - *Faculty
MH  - Female
MH  - Humans
MH  - Internet
MH  - Male
MH  - *Morals
MH  - Problem Solving/*ethics
MH  - Serbia
MH  - Surveys and Questionnaires
MH  - Teaching
MH  - *Thinking
EDAT- 2010/01/29 06:00
MHDA- 2012/02/10 06:00
CRDT- 2010/01/29 06:00
PHST- 2009/12/07 00:00 [received]
PHST- 2009/12/26 00:00 [accepted]
PHST- 2010/01/29 06:00 [entrez]
PHST- 2010/01/29 06:00 [pubmed]
PHST- 2012/02/10 06:00 [medline]
AID - 10.1007/s11948-009-9190-x [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2011 Jun;17(2):299-320. doi: 10.1007/s11948-009-9190-x. Epub 2010
      Jan 27.


PMID- 20107367
OWN - NLM
STAT- MEDLINE
DCOM- 20100223
LR  - 20220321
IS  - 1938-808X (Electronic)
IS  - 1040-2446 (Linking)
VI  - 85
IP  - 2
DP  - 2010 Feb
TI  - Flexner revisited: the role and value of the basic sciences in medical education.
PG  - 349-55
LID - 10.1097/ACM.0b013e3181c88b09 [doi]
AB  - A central tenet of Flexner's report was the fundamental role of science in
      medical education. Today, there is tension between the time needed to teach an
      ever-expanding knowledge base in science and the time needed for increased
      instruction in clinical application and in the behavioral, ethical, and
      managerial knowledge and skills needed to prepare for clinical experiences. One
      result has been at least a perceived reduction in time and focus on the
      foundational sciences. In this context, the International Association of Medical 
      Science Educators initiated a study to address the role and value of the basic
      sciences in medical education by seeking perspectives from various groups of
      medical educators to five questions: (1) What are the sciences that constitute
      the foundation for medical practice? (2) What is the value and role of the
      foundational sciences in medical education? (3) When and how should these
      foundational sciences be incorporated into the medical education curriculum? (4) 
      What sciences should be prerequisite to entering the undergraduate medical
      curriculum? (5) What are examples of the best practices for incorporating the
      foundational sciences into the medical education curriculum? The results suggest 
      a broad group of experts believes that an understanding of basic science content 
      remains essential to clinical practice and that teaching should be accomplished
      across the entire undergraduate medical education experience and integrated with 
      clinical applications. Learning the sciences also plays a foundational role in
      developing discipline and rigor in learners' thinking skills, including logical
      reasoning, critical appraisal, problem solving, decision making, and creativity.
FAU - Finnerty, Edward P
AU  - Finnerty EP
AD  - Department of Physiology/Pharmacology, Des Moines University, Des Moines, Iowa
      50312, USA. edward.finnerty@dmu.edu
FAU - Chauvin, Sheila
AU  - Chauvin S
FAU - Bonaminio, Giulia
AU  - Bonaminio G
FAU - Andrews, Mark
AU  - Andrews M
FAU - Carroll, Robert G
AU  - Carroll RG
FAU - Pangaro, Louis N
AU  - Pangaro LN
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Acad Med
JT  - Academic medicine : journal of the Association of American Medical Colleges
JID - 8904605
SB  - IM
MH  - Biological Science Disciplines/*education
MH  - *Curriculum
MH  - Education, Medical/*standards
MH  - Education, Premedical/*standards
MH  - Focus Groups
MH  - Humans
MH  - School Admission Criteria
EDAT- 2010/01/29 06:00
MHDA- 2010/02/24 06:00
CRDT- 2010/01/29 06:00
PHST- 2010/01/29 06:00 [entrez]
PHST- 2010/01/29 06:00 [pubmed]
PHST- 2010/02/24 06:00 [medline]
AID - 10.1097/ACM.0b013e3181c88b09 [doi]
AID - 00001888-201002000-00039 [pii]
PST - ppublish
SO  - Acad Med. 2010 Feb;85(2):349-55. doi: 10.1097/ACM.0b013e3181c88b09.


PMID- 20107362
OWN - NLM
STAT- MEDLINE
DCOM- 20100223
LR  - 20100128
IS  - 1938-808X (Electronic)
IS  - 1040-2446 (Linking)
VI  - 85
IP  - 2
DP  - 2010 Feb
TI  - Reforming medical education in ethics and humanities by finding common ground
      with Abraham Flexner.
PG  - 318-23
LID - 10.1097/ACM.0b013e3181c85932 [doi]
AB  - Abraham Flexner was commissioned by the Carnegie Foundation for the Advancement
      of Teaching to conduct the 1910 survey of all U.S. and Canadian medical schools
      because medical education was perceived to lack rigor and strong learning
      environments. Existing proprietary schools were shown to have inadequate student 
      scholarship and substandard faculty and teaching venues. Flexner's efforts and
      those of the American Medical Association resulted in scores of inadequate
      medical schools being closed and the curricula of the survivors being radically
      changed. Flexner presumed that medical students would already be schooled in the 
      humanities in college. He viewed the humanities as essential to physician
      development but did not explicitly incorporate this position into his 1910
      report, although he emphasized this point in later writings. Medical ethics and
      humanities education since 1970 has sought integration with the sciences in
      medical school. Most programs, however, are not well integrated with the
      scientific/clinical curriculum, comprehensive across four years of training, or
      cohesive with nationally formulated goals and objectives. The authors propose a
      reformation of medical humanities teaching in medical schools inspired by
      Flexner's writings on premedical education in the context of contemporary
      educational requirements. College and university education in the humanities is
      committed to a broad education, consistent with long-standing tenets of liberal
      arts education. As a consequence, premedical students do not study clinically
      oriented science or humanities. The medical school curriculum already provides
      teaching of clinically relevant sciences. The proposed four-year curriculum
      should likewise provide clinically relevant humanities teaching to train medical 
      students and residents comprehensively in humane, professional patient care.
FAU - Doukas, David J
AU  - Doukas DJ
AD  - Division of Medical Humanism and Ethics, Department of Family and Geriatric
      Medicine, University of Louisville, Louisville, Kentucky 40202, USA.
      david.doukas@louisville.edu
FAU - McCullough, Laurence B
AU  - McCullough LB
FAU - Wear, Stephen
AU  - Wear S
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Acad Med
JT  - Academic medicine : journal of the Association of American Medical Colleges
JID - 8904605
SB  - IM
MH  - Curriculum
MH  - Education, Medical, Undergraduate/*history/methods/standards
MH  - Ethics, Medical/*education
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humanities/*education
MH  - Humans
EDAT- 2010/01/29 06:00
MHDA- 2010/02/24 06:00
CRDT- 2010/01/29 06:00
PHST- 2010/01/29 06:00 [entrez]
PHST- 2010/01/29 06:00 [pubmed]
PHST- 2010/02/24 06:00 [medline]
AID - 10.1097/ACM.0b013e3181c85932 [doi]
AID - 00001888-201002000-00034 [pii]
PST - ppublish
SO  - Acad Med. 2010 Feb;85(2):318-23. doi: 10.1097/ACM.0b013e3181c85932.


PMID- 20105584
OWN - NLM
STAT- MEDLINE
DCOM- 20100312
LR  - 20141120
IS  - 1531-5037 (Electronic)
IS  - 0022-3468 (Linking)
VI  - 45
IP  - 1
DP  - 2010 Jan
TI  - Hybrid notes: incisionless intragastric stapled cystgastrostomy of a pancreatic
      pseudocyst.
PG  - 80-3
LID - 10.1016/j.jpedsurg.2009.10.015 [doi]
AB  - PURPOSE: We present a case report of a novel hybrid natural orifice transluminal 
      endoscopic surgery (NOTES). The operation performed was a transgastric
      cystgastrostomy with endoscopic guidance for a pancreatic pseudocyst. This
      operation was completed entirely through an existing gastrostomy site with no
      incisions, thus avoiding the peritoneal cavity. METHODS: This is a case of a
      7-year-old boy with neurologic impairment from congenital herpes simplex virus
      encephalitis who is tube fed. He had acute pancreatitis and developed a 9 cm
      pancreatic pseudocyst. The pseudocyst failed to resolve after 6 weeks and
      developed a mature wall. Due to a history of multiple abdominal surgeries and
      known abdominal adhesions, a minimally invasive approach that would avoid
      entering the peritoneal cavity was the desired approach. The technique involved a
      trans-oral endoscope for visualization and the use of the gastrostomy as access
      to the gastric lumen and pseudocyst. The pancreatic pseudocyst was stabilized
      with two T-fasteners and confirmed with needle aspiration under endoscopic
      visualization. The pseudocyst was then opened with the LigaSure (Valleylab,
      Boulder, CO). The cystgastrostomy anastomosis was completed with an Endopath
      ETS-Flex Articulating Linear Stapler/Cutter (Ethicon Endo-Surgery, Inc,
      Cincinnati, OH). The operation took less than 2 hours and was completed without
      an incision. Under the policies of the Human Research Protection Program, review 
      of a single case is outside the scope of the definition of human subjects
      research and does not require institutional review board review and approval.
      RESULTS: The patient did well postoperatively and had a dramatic reduction in
      size of the pancreatic pseudocyst to 3.5 cm by 2 weeks. CONCLUSIONS: Hybrid NOTES
      cystgastrostomy performed through an existing gastrocutaneous fistula is an
      excellent approach for minimally invasive drainage of pancreatic pseudocysts.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Rossini, Connie J
AU  - Rossini CJ
AD  - Baystate Medical Center, Tufts University School of Medicine, Springfield, MA
      01103, USA.
FAU - Moriarty, Kevin P
AU  - Moriarty KP
FAU - Angelides, Anastasios G
AU  - Angelides AG
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Pediatr Surg
JT  - Journal of pediatric surgery
JID - 0052631
SB  - IM
MH  - Child
MH  - Drainage/methods
MH  - Gastroscopy/*methods
MH  - Gastrostomy/*methods
MH  - Humans
MH  - Male
MH  - Minimally Invasive Surgical Procedures
MH  - Pancreatic Pseudocyst/*surgery
MH  - Surgical Stapling/*methods
EDAT- 2010/01/29 06:00
MHDA- 2010/03/13 06:00
CRDT- 2010/01/29 06:00
PHST- 2009/09/26 00:00 [received]
PHST- 2009/10/06 00:00 [accepted]
PHST- 2010/01/29 06:00 [entrez]
PHST- 2010/01/29 06:00 [pubmed]
PHST- 2010/03/13 06:00 [medline]
AID - S0022-3468(09)00797-0 [pii]
AID - 10.1016/j.jpedsurg.2009.10.015 [doi]
PST - ppublish
SO  - J Pediatr Surg. 2010 Jan;45(1):80-3. doi: 10.1016/j.jpedsurg.2009.10.015.


PMID- 20105464
OWN - NLM
STAT- MEDLINE
DCOM- 20100224
LR  - 20100128
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 93
IP  - 2
DP  - 2010 Feb
TI  - A preventive ethics approach to IVF in the age of octuplets.
PG  - 339-40
LID - 10.1016/j.fertnstert.2009.12.010 [doi]
AB  - A preventive ethics approach recognizes that ethical obligations of the in vitro 
      fertilization practitioner should prevail, regardless of whether embryo transfer 
      is regulated.
CI  - Copyright 2010. Published by Elsevier Inc.
FAU - Rosenthal, M Sara
AU  - Rosenthal MS
AD  - Program for Bioethics, Department of Internal Medicine, University of Kentucky,
      740 South LimestoneStreet Lexington, Kentucky 40536-0284, USA.
      msrose2@email.uky.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
SB  - IM
MH  - Decision Making
MH  - *Ethics, Medical
MH  - Female
MH  - Fertilization in Vitro/*ethics
MH  - Humans
MH  - Informed Consent
MH  - Judgment
MH  - Personal Autonomy
MH  - Pregnancy
MH  - Pregnancy Reduction, Multifetal/ethics
MH  - *Pregnancy, Multiple/psychology
EDAT- 2010/01/29 06:00
MHDA- 2010/02/25 06:00
CRDT- 2010/01/29 06:00
PHST- 2009/12/02 00:00 [received]
PHST- 2009/12/02 00:00 [accepted]
PHST- 2010/01/29 06:00 [entrez]
PHST- 2010/01/29 06:00 [pubmed]
PHST- 2010/02/25 06:00 [medline]
AID - S0015-0282(09)04178-8 [pii]
AID - 10.1016/j.fertnstert.2009.12.010 [doi]
PST - ppublish
SO  - Fertil Steril. 2010 Feb;93(2):339-40. doi: 10.1016/j.fertnstert.2009.12.010.


PMID- 20105463
OWN - NLM
STAT- MEDLINE
DCOM- 20100224
LR  - 20100128
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 93
IP  - 2
DP  - 2010 Feb
TI  - The American octuplet experience: a transformative event.
PG  - 337-8
LID - 10.1016/j.fertnstert.2009.12.011 [doi]
AB  - The Suleman case has served as a catalyst to examine a range of clinical and
      ethical decisions, making the birth of the octuplets a truly transformative
      event.
CI  - Copyright 2010. Published by Elsevier Inc.
FAU - Ory, S
AU  - Ory S
AD  - Florida International University, Miami, Florida, USA. sjory@msn.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
SB  - IM
MH  - Adult
MH  - California
MH  - Ethics, Medical
MH  - Female
MH  - Fertilization in Vitro/*ethics
MH  - Humans
MH  - Multiple Birth Offspring/*statistics & numerical data
MH  - Pregnancy
MH  - *Pregnancy, Multiple
MH  - Single Person
EDAT- 2010/01/29 06:00
MHDA- 2010/02/25 06:00
CRDT- 2010/01/29 06:00
PHST- 2009/12/02 00:00 [received]
PHST- 2009/12/02 00:00 [accepted]
PHST- 2010/01/29 06:00 [entrez]
PHST- 2010/01/29 06:00 [pubmed]
PHST- 2010/02/25 06:00 [medline]
AID - S0015-0282(09)04179-X [pii]
AID - 10.1016/j.fertnstert.2009.12.011 [doi]
PST - ppublish
SO  - Fertil Steril. 2010 Feb;93(2):337-8. doi: 10.1016/j.fertnstert.2009.12.011.


PMID- 20104687
OWN - NLM
STAT- MEDLINE
DCOM- 20100218
LR  - 20100324
IS  - 0003-1488 (Print)
IS  - 0003-1488 (Linking)
VI  - 236
IP  - 2
DP  - 2010 Jan 15
TI  - Veterinary profession, animal welfare ethics evolve together. The question is:
      should veterinarians press for change or follow?
PG  - 138-9
FAU - Nolen, R Scott
AU  - Nolen RS
LA  - eng
PT  - News
PL  - United States
TA  - J Am Vet Med Assoc
JT  - Journal of the American Veterinary Medical Association
JID - 7503067
SB  - IM
CIN - J Am Vet Med Assoc. 2010 Mar 1;236(5):509. PMID: 20187811
MH  - Animal Welfare/*ethics/*trends
MH  - Education, Veterinary
MH  - Leadership
MH  - *Veterinarians
MH  - Veterinary Medicine/*ethics/*trends
EDAT- 2010/01/29 06:00
MHDA- 2010/02/19 06:00
CRDT- 2010/01/29 06:00
PHST- 2010/01/29 06:00 [entrez]
PHST- 2010/01/29 06:00 [pubmed]
PHST- 2010/02/19 06:00 [medline]
PST - ppublish
SO  - J Am Vet Med Assoc. 2010 Jan 15;236(2):138-9.


PMID- 20104478
OWN - NLM
STAT- MEDLINE
DCOM- 20100413
LR  - 20100201
IS  - 1527-6473 (Electronic)
IS  - 1527-6465 (Linking)
VI  - 16
IP  - 2
DP  - 2010 Feb
TI  - The dilemma and reality of transplant tourism: an ethical perspective for liver
      transplant programs.
PG  - 113-7
LID - 10.1002/lt.21967 [doi]
AB  - Transplant programs are likely to encounter increasing numbers of patients who
      return after receiving an organ transplant abroad. These patients will require
      ongoing medical care to monitor their immunosuppression and to provide treatment 
      when the need arises. Transplant societies have condemned transplantation with
      organs purchased abroad and with organs procured from executed prisoners in
      China. Nevertheless, transplant programs require guidance on how to respond to
      the needs of returning transplant tourists and to the needs of patients who may
      choose to become transplant tourists. This discussion presents a case that raised
      such issues in our program. It goes on to offer reasons for considering a
      program's responses in terms of the most relevant principles of medical ethics,
      namely beneficence and nonjudgmental regard.
FAU - Schiano, Thomas D
AU  - Schiano TD
AD  - Division of Liver Diseases, Mount Sinai School of Medicine, New York 10029, NY.
      thomas.schiano@mountsinai.org
FAU - Rhodes, Rosamond
AU  - Rhodes R
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Liver Transpl
JT  - Liver transplantation : official publication of the American Association for the 
      Study of Liver Diseases and the International Liver Transplantation Society
JID - 100909185
SB  - IM
MH  - Humans
MH  - Internationality
MH  - Liver Failure/*surgery
MH  - Liver Transplantation/*ethics
MH  - Male
MH  - Medical Tourism/*ethics
MH  - Middle Aged
MH  - Postoperative Complications/*surgery
MH  - Practice Guidelines as Topic
MH  - Reoperation/*ethics
MH  - Sepsis
MH  - Waiting Lists
EDAT- 2010/01/28 06:00
MHDA- 2010/04/14 06:00
CRDT- 2010/01/28 06:00
PHST- 2010/01/28 06:00 [entrez]
PHST- 2010/01/28 06:00 [pubmed]
PHST- 2010/04/14 06:00 [medline]
AID - 10.1002/lt.21967 [doi]
PST - ppublish
SO  - Liver Transpl. 2010 Feb;16(2):113-7. doi: 10.1002/lt.21967.


PMID- 20104435
OWN - NLM
STAT- MEDLINE
DCOM- 20100503
LR  - 20191210
IS  - 1439-4421 (Electronic)
IS  - 0941-3790 (Linking)
VI  - 72
IP  - 1
DP  - 2010 Jan
TI  - [Health targets for health promotion in an area of conflict between individual
      freedom, state paternalism and common welfare].
PG  - 41-7
LID - 10.1055/s-0029-1237742 [doi]
AB  - In Germany, a growing number of health targets has been adopted in the last years
      by various actors. While health targets are a useful instrument of governance,
      the priority setting and a respective redistribution of resources have to be
      legitimised in the cause of their advantages and disadvantages for population
      groups. The involved sciences including ethics can support decision-making, but
      not fully justify decisions. Therefore, decisions on health targets must be made 
      in a transparent and participative process. In spite of a growing number of
      health targets, the lack of targets in health policies is to be criticised.
      Within the health targets, those measures assigned to curative medicine and
      prevention have a greater weight than health promotion. Health promotion should
      follow the WHO Ottawa-Charter and be embedded in the concept of "capabilities".
      Under these conditions, a stronger consideration of health promotion in the
      health target process would be desirable. However, the present actor
      constellations within health target processes make such a direction improbable.
      The struggle around capabilities and individual freedom occurs through, in and
      about institutions of the civil society as well as political and legal
      institutions. To restrict the discussion about public health and health
      promotions to an juxtaposition of individual freedom and state paternalism
      minimises societal and social restrictions of individual freedom as well as the
      possibility of a safeguard and enlargement of individual freedoms through
      political and legal institutions.
FAU - Michelsen, K
AU  - Michelsen K
AD  - Faculty of Health, Medicine and Life Sciences, Department of International
      Health, Maastricht, the Netherlands. Kai.Michelsen@inthealth.unimaas.nl
LA  - ger
PT  - Journal Article
TT  - Gesundheitsziele zur Gesundheitsforderung im Spannungsfeld von individueller
      Freiheit, staatlichem Paternalismus und Gemeinwohl.
DEP - 20100126
PL  - Germany
TA  - Gesundheitswesen
JT  - Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes
      (Germany))
JID - 9204210
SB  - IM
MH  - Bioethics/trends
MH  - Community Participation/trends
MH  - *Conflict, Psychological
MH  - Forecasting
MH  - Germany
MH  - *Goals
MH  - Health Policy/*trends
MH  - Health Priorities/ethics/trends
MH  - Health Promotion/ethics/*trends
MH  - Healthcare Disparities/ethics/trends
MH  - Humans
MH  - National Health Programs/*trends
MH  - *Paternalism/ethics
MH  - *Personal Autonomy
MH  - Primary Prevention/ethics/*trends
MH  - *Social Responsibility
MH  - Social Values
MH  - World Health Organization
EDAT- 2010/01/28 06:00
MHDA- 2010/05/04 06:00
CRDT- 2010/01/28 06:00
PHST- 2010/01/28 06:00 [entrez]
PHST- 2010/01/28 06:00 [pubmed]
PHST- 2010/05/04 06:00 [medline]
AID - 10.1055/s-0029-1237742 [doi]
PST - ppublish
SO  - Gesundheitswesen. 2010 Jan;72(1):41-7. doi: 10.1055/s-0029-1237742. Epub 2010 Jan
      26.


PMID- 20104375
OWN - NLM
STAT- MEDLINE
DCOM- 20100628
LR  - 20151119
IS  - 1424-3997 (Electronic)
IS  - 0036-7672 (Linking)
VI  - 140
IP  - 11-12
DP  - 2010 Mar 20
TI  - The reception and implementation of ethical guidelines of the Swiss Academy of
      Medical Sciences in medical and nursing practice.
PG  - 160-7
LID - smw-12647 [doi]
AB  - QUESTIONS UNDER STUDY: We conducted a survey among Swiss health care
      professionals on the reception and implementation of a number of selected ethical
      guidelines of the Swiss Academy of Medical Sciences (SAMS). The following
      guidelines were chosen for evaluation: "Care of patients in the end of life",
      "Palliative care", "Borderline questions in intensive-care medicine" and "The
      determination of death in the context of organ transplantation". METHODS:
      Anonymous questionnaires were sent to 1933 physicians (general practitioners and 
      internists) and nurses, randomly chosen from address lists of the relevant
      professional associations. We conducted a statistical analysis using SPSS 16.0.
      RESULTS: The response rate was 43.1%. 16.3% of the responding physicians had
      never heard of the guidelines "Care of patients in the end of life", 30.5% had
      already heard of them, 34.1% knew some of their contents and 19.1% were familiar 
      with the complete content of the guidelines. 60.5% of those physicians and 56.0% 
      of those nurses who had at least heard of these guidelines utilised them in
      clinical practice. The guidelines "Palliative care" and "Borderline questions in 
      intensive-care medicine" yielded similar results. By contrast, only 0.5% of
      responding physicians reported never having heard of the guidelines "The
      determination of death in the context of organ transplantation", 2.9% had already
      heard of them, 24.4% knew some of their contents and the vast majority of
      respondents (72.2%) considered themselves to be completely familiar with the
      guidelines. CONCLUSION: Knowledge of the evaluated guidelines is fairly
      widespread among Swiss GPs, internists and nurses. The guidelines are utilised in
      clinical practice by the majority of those care providers who are aware of their 
      existence. The guidelines "The determination of death in the context of organ
      transplantation", as a legally binding document, are even better known and
      routinely implemented in medical practice.
FAU - Pfister, Eliane
AU  - Pfister E
AD  - Institute of Biomedical Ethics, University of Zurich, Zollikerstrasse 115,
      Zurich, Switzerland. pfister@ethik.uzh.ch
FAU - Biller-Adorno, Nikola
AU  - Biller-Adorno N
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Swiss Med Wkly
JT  - Swiss medical weekly
JID - 100970884
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Codes of Ethics
MH  - Female
MH  - Health Care Surveys
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nursing Process/*ethics
MH  - Practice Patterns, Physicians'/*ethics
MH  - Surveys and Questionnaires
MH  - Switzerland
MH  - *Universities
MH  - Young Adult
EDAT- 2010/01/28 06:00
MHDA- 2010/06/29 06:00
CRDT- 2010/01/28 06:00
PHST- 2010/01/28 06:00 [entrez]
PHST- 2010/01/28 06:00 [pubmed]
PHST- 2010/06/29 06:00 [medline]
AID - smw-12647 [pii]
AID - smw-12647 [doi]
PST - ppublish
SO  - Swiss Med Wkly. 2010 Mar 20;140(11-12):160-7. doi: smw-12647.


PMID- 20104202
OWN - NLM
STAT- MEDLINE
DCOM- 20100218
LR  - 20211020
IS  - 1546-1726 (Electronic)
IS  - 1097-6256 (Linking)
VI  - 13
IP  - 2
DP  - 2010 Feb
TI  - Ethical neuroscience.
PG  - 141
LID - 10.1038/nn0210-141 [doi]
LA  - eng
PT  - Editorial
PL  - United States
TA  - Nat Neurosci
JT  - Nature neuroscience
JID - 9809671
SB  - IM
MH  - Animals
MH  - Biomedical Research/*ethics/*methods
MH  - Databases as Topic
MH  - Decision Making, Organizational
MH  - *Ethics Committees, Research
MH  - Humans
MH  - Neurosciences/*ethics
EDAT- 2010/01/28 06:00
MHDA- 2010/02/19 06:00
CRDT- 2010/01/28 06:00
PHST- 2010/01/28 06:00 [entrez]
PHST- 2010/01/28 06:00 [pubmed]
PHST- 2010/02/19 06:00 [medline]
AID - nn0210-141 [pii]
AID - 10.1038/nn0210-141 [doi]
PST - ppublish
SO  - Nat Neurosci. 2010 Feb;13(2):141. doi: 10.1038/nn0210-141.


PMID- 20104034
OWN - NLM
STAT- MEDLINE
DCOM- 20100419
LR  - 20191027
IS  - 1710-2774 (Print)
IS  - 1710-2774 (Linking)
VI  - 13
IP  - 1
DP  - 2010
TI  - Contextualizing ethics: ventilators, H1N1 and marginalized populations.
PG  - 32-6
AB  - If the H1N1 pandemic worsens, there may not be enough ventilated beds to care for
      all persons with respiratory failure. To date, researchers who explicitly discuss
      the ethics of intensive care unit admission and the allocation of ventilators
      during an influenza pandemic have based criteria predominantly on the principles 
      of utility and efficiency, that is, promoting actions that maximize the greatest 
      good for the greatest number of people. However, haphazardly applying utility and
      efficiency potentially disadvantages marginalized populations who might be at
      increased risk of severe reactions to H1N1. In Canada, Aboriginals represent 3%
      of Canadians, yet 11% of H1N1 cases requiring hospitalization involve Aboriginal 
      persons. Aboriginal persons suffer from high rates of obesity due to
      socio-economic inequalities. Obesity is also a risk factor for severe H1N1
      reactions. Yet, since obesity is found to increase the duration of stay in
      ventilated beds and a long stay is not considered an optimal use of ventilators, 
      applying the principles of utility and efficiency may magnify existing social
      inequalities. Although promoting utility and efficiency is important, other
      ethical principles, such as equity and need, require thoughtful consideration and
      implementation. Furthermore, since public resources are being used to address a
      public health hazard, the viewpoints of the public, and specifically stakeholders
      who will be disproportionately affected, should inform decision-makers. Finally, 
      giving attention to the needs and rights of marginalized populations means that
      ventilators should not be allocated based on criteria that exacerbate the social 
      injustices faced by these groups of people.
FAU - Silva, Diego S
AU  - Silva DS
AD  - Dalla Lana School of Public Health, University of Toronto.
FAU - Nie, Jason X
AU  - Nie JX
FAU - Rossiter, Kate
AU  - Rossiter K
FAU - Sahni, Sachin
AU  - Sahni S
FAU - Upshur, Ross E G
AU  - Upshur RE
CN  - Canadian Program of Research on Ethics in a Pandemic
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Healthc Q
JT  - Healthcare quarterly (Toronto, Ont.)
JID - 101208192
MH  - Delivery of Health Care/*ethics
MH  - Humans
MH  - *Influenza A Virus, H1N1 Subtype
MH  - *Influenza, Human
MH  - Intensive Care Units
MH  - Patient Admission
MH  - Population Groups
MH  - Social Justice
MH  - Ventilators, Mechanical/*supply & distribution
MH  - *Vulnerable Populations
EDAT- 2010/01/28 06:00
MHDA- 2010/04/20 06:00
CRDT- 2010/01/28 06:00
PHST- 2010/01/28 06:00 [entrez]
PHST- 2010/01/28 06:00 [pubmed]
PHST- 2010/04/20 06:00 [medline]
AID - 10.12927/hcq.2013.21613 [doi]
PST - ppublish
SO  - Healthc Q. 2010;13(1):32-6. doi: 10.12927/hcq.2013.21613.


PMID- 20102543
OWN - NLM
STAT- MEDLINE
DCOM- 20101021
LR  - 20151119
IS  - 1471-6712 (Electronic)
IS  - 0283-9318 (Linking)
VI  - 24
IP  - 2
DP  - 2010 Jun
TI  - The association among hypertension and reduced psychological well-being, anxiety 
      and sleep disturbances: a population study.
PG  - 366-71
LID - 10.1111/j.1471-6712.2009.00730.x [doi]
AB  - Hypertension (HP) is a serious condition affecting about one quarter of all
      adults, both men and women. Genetic and environmental factors are of importance
      in its aetiology, while psychosocial factors may also play a role. This study
      focused on psychosocial factors and examined the association among reduced
      psychological well-being, anxiety, sleep disturbances and HP by comparing people 
      with HP and the general population. A national survey of 12,166 individuals
      (hypertensives n = 2047; rest of population n = 10,119) was conducted using
      two-step multiple logistic regression with an odds ratio and a 95% confidence
      interval. The study is in accordance with Swedish legislation pertaining to
      ethics. Reduced psychological well-being, anxiety and sleep disturbances were
      higher in the HP group and, in addition, reduced psychological well-being was,
      still higher in the presence of severe anxiety and serious sleep disturbances.
      These three factors are of major importance for HP, but it is difficult to know
      whether they are causes or consequences. In order to prevent HP, support for
      people who exhibit such risk factors should be a matter of high priority.
FAU - Hildingh, Cathrine
AU  - Hildingh C
AD  - School of Social and Health Sciences, Halmstad University, Halmstad, Sweden.
      cathrine.hildingh@hh.se
FAU - Baigi, Amir
AU  - Baigi A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100120
PL  - Sweden
TA  - Scand J Caring Sci
JT  - Scandinavian journal of caring sciences
JID - 8804206
MH  - *Anxiety
MH  - Female
MH  - Humans
MH  - Hypertension/*complications/psychology
MH  - Male
MH  - *Mental Health
MH  - Middle Aged
MH  - Sleep Wake Disorders/*complications
EDAT- 2010/01/28 06:00
MHDA- 2010/10/22 06:00
CRDT- 2010/01/28 06:00
PHST- 2010/01/28 06:00 [entrez]
PHST- 2010/01/28 06:00 [pubmed]
PHST- 2010/10/22 06:00 [medline]
AID - SCS730 [pii]
AID - 10.1111/j.1471-6712.2009.00730.x [doi]
PST - ppublish
SO  - Scand J Caring Sci. 2010 Jun;24(2):366-71. doi: 10.1111/j.1471-6712.2009.00730.x.
      Epub 2010 Jan 20.


PMID- 20102502
OWN - NLM
STAT- MEDLINE
DCOM- 20100603
LR  - 20161018
IS  - 0891-6640 (Print)
IS  - 0891-6640 (Linking)
VI  - 24
IP  - 2
DP  - 2010 Mar-Apr
TI  - Heritability of exocrine pancreatic insufficiency in German Shepherd dogs.
PG  - 450-2
LID - 10.1111/j.1939-1676.2009.0461.x [doi]
AB  - BACKGROUND: Several studies have revealed that exocrine pancreatic insufficiency 
      (EPI) is an inherited disease in German Shepherd Dogs (GSDs). Pedigree analyses
      have suggested an autosomal recessive inheritance model. OBJECTIVE: Test mating
      of 2 dogs with EPI. ANIMALS: A sire and dam purebred GSD both with EPI and a
      litter of 6 puppies. METHODS: Test mating and long-term follow-up of offspring.
      The pancreas was biopsied via laparotomy on 26 occasions. Serum trypsin-like
      immunoreactivity was measured. Study was approved by Animal Ethics Committee.
      RESULTS: During the 12-year study period only 2 of the 6 offsprings developed
      pancreatic acinar atrophy (PAA). In 1 puppy, end-stage PAA and in the other puppy
      partial PAA was diagnosed. CONCLUSIONS AND CLINICAL IMPORTANCE: PAA is not a
      congenital disease in GSDs. This study provided evidence that PAA is not
      inherited in a simple autosomal recessive fashion.
FAU - Westermarck, E
AU  - Westermarck E
AD  - Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine,
      University of Helsinki, P.O. Box 57, 00014 Helsinki, Finland.
      elias.westermarck@helsinki.fi
FAU - Saari, S A M
AU  - Saari SA
FAU - Wiberg, M E
AU  - Wiberg ME
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Vet Intern Med
JT  - Journal of veterinary internal medicine
JID - 8708660
SB  - IM
MH  - Animals
MH  - Dog Diseases/*genetics
MH  - Dogs
MH  - Exocrine Pancreatic Insufficiency/genetics/*veterinary
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Male
EDAT- 2010/01/28 06:00
MHDA- 2010/06/04 06:00
CRDT- 2010/01/28 06:00
PHST- 2010/01/28 06:00 [entrez]
PHST- 2010/01/28 06:00 [pubmed]
PHST- 2010/06/04 06:00 [medline]
AID - JVIM461 [pii]
AID - 10.1111/j.1939-1676.2009.0461.x [doi]
PST - ppublish
SO  - J Vet Intern Med. 2010 Mar-Apr;24(2):450-2. doi: 10.1111/j.1939-1676.2009.0461.x.


PMID- 20075121
OWN - NLM
STAT- MEDLINE
DCOM- 20100318
LR  - 20220408
IS  - 1758-1060 (Electronic)
IS  - 1355-8196 (Linking)
VI  - 15 Suppl 1
DP  - 2010 Jan
TI  - Learning about patient safety: organizational context and culture in the
      education of health care professionals.
PG  - 4-10
LID - 10.1258/jhsrp.2009.009052 [doi]
AB  - OBJECTIVES: This study investigated the formal and informal ways pre-registration
      students from medicine, nursing, physiotherapy and pharmacy learn about keeping
      patients safe. This paper gives an overview of the study and explores findings in
      relation to organizational context and culture. METHODS: The study employed a
      phased design using multiple qualitative methods. The overall approach drew on
      'illuminative evaluation'. Ethical approval was obtained. Phase 1 employed a
      convenience sample of 13 pre-registration courses across the UK. Curriculum
      documents were gathered, and course directors interviewed. Phase 2 used eight
      case studies, two for each professional group, to develop an in-depth
      investigation of learning across university and practice by students and
      newly-qualified practitioners in relation to patient safety, and to examine the
      organizational culture that students and newly-qualified staff are exposed to.
      Analysis was iterative and ongoing throughout the study, using frameworks agreed 
      by all researchers. RESULTS: Patient safety was felt to have become a higher
      priority for the health care system in recent years. Incident reporting was a key
      feature of the patient safety agenda within the organizations examined. Staff
      were often unclear or too busy to report. On the whole, students were not engaged
      and may not be aware of incident reporting schemes. They may not have access to
      existing systems in their organization. Most did not access employers' induction 
      programmes. Some training sessions occasionally included students but this did
      not appear to be routine. CONCLUSIONS: Action is needed to develop an efficient
      interface between employers and education providers to develop up-to-date
      curricula for patient safety.
FAU - Pearson, Pauline
AU  - Pearson P
AD  - School of Medical Sciences Education Development, Newcastle University,
      Framlington Place, Newcastle upon Tyne, UK. p.h.pearson@ncl.ac.uk
FAU - Steven, Alison
AU  - Steven A
FAU - Howe, Amanda
AU  - Howe A
FAU - Sheikh, Aziz
AU  - Sheikh A
FAU - Ashcroft, Darren
AU  - Ashcroft D
FAU - Smith, Pam
AU  - Smith P
CN  - Patient Safety Education Study Group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Health Serv Res Policy
JT  - Journal of health services research & policy
JID - 9604936
MH  - Attitude of Health Personnel
MH  - *Curriculum
MH  - Education, Professional/*methods
MH  - Health Personnel/*education
MH  - Humans
MH  - Interviews as Topic
MH  - Medical Errors/prevention & control
MH  - Organizational Culture
MH  - Qualitative Research
MH  - Risk Management
MH  - Safety Management/*organization & administration
MH  - Schools, Health Occupations
MH  - State Medicine
MH  - United Kingdom
EDAT- 2010/01/28 06:00
MHDA- 2010/03/20 06:00
CRDT- 2010/01/16 06:00
PHST- 2010/01/16 06:00 [entrez]
PHST- 2010/01/28 06:00 [pubmed]
PHST- 2010/03/20 06:00 [medline]
AID - 15/suppl_1/4 [pii]
AID - 10.1258/jhsrp.2009.009052 [doi]
PST - ppublish
SO  - J Health Serv Res Policy. 2010 Jan;15 Suppl 1:4-10. doi:
      10.1258/jhsrp.2009.009052.


PMID- 20101630
OWN - NLM
STAT- MEDLINE
DCOM- 20100614
LR  - 20220330
IS  - 1521-6551 (Electronic)
IS  - 1521-6543 (Linking)
VI  - 62
IP  - 4
DP  - 2010 Apr
TI  - Porcine induced pluripotent stem cells may bridge the gap between mouse and human
      iPS.
PG  - 277-82
LID - 10.1002/iub.307 [doi]
AB  - Recently, three independent laboratories reported the generation of induced
      pluripotent stem cells (iPSCs) from pig (Sus scrofa). This finding sums to the
      growing list of species (mouse, human, monkey, and rat, in this order) for which 
      successful reprogramming using exogenous factors has been achieved, and multiple 
      others are possibly forthcoming. But apart from demonstrating the universality of
      the network identified by Shinya Yamanaka, what makes the porcine model so
      special? On one side, pigs are an agricultural commodity and have an easy and
      affordable maintenance compared with nonhuman primates that normally need to be
      imported. On the other side, resemblance (for example, size of organs) of porcine
      and human physiology is striking and because pigs are a regular source of food
      the ethical concerns that still remain in monkeys are not applicable. Besides,
      the prolonged lifespan of pigs compared with other domestic species can allow
      exhaustive follow up of side effects after transplantation. Porcine iPSCs may
      thus fill the gap between the mouse model, which due to its ease is preferred for
      mechanistic studies, and the first clinical trials using iPSCs in humans.
      However, although these studies are relevant and have created significant
      interest they face analogous problems that we discuss herein together with
      potential new directions.
FAU - Esteban, Miguel A
AU  - Esteban MA
AD  - Stem Cell and Cancer Biology Group, Key Laboratory of Regenerative Biology, South
      China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou
      Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou,
      China.
FAU - Peng, Meixiu
AU  - Peng M
FAU - Deli, Zhang
AU  - Deli Z
FAU - Cai, Jie
AU  - Cai J
FAU - Yang, Jiayin
AU  - Yang J
FAU - Xu, Jianyong
AU  - Xu J
FAU - Lai, Liangxue
AU  - Lai L
FAU - Pei, Duanqing
AU  - Pei D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - IUBMB Life
JT  - IUBMB life
JID - 100888706
SB  - IM
MH  - Animals
MH  - Haplorhini/genetics/metabolism
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*cytology
MH  - Mice
MH  - Rats
MH  - Sus scrofa/genetics/*metabolism
MH  - Swine/metabolism
RF  - 42
EDAT- 2010/01/27 06:00
MHDA- 2010/06/15 06:00
CRDT- 2010/01/27 06:00
PHST- 2010/01/27 06:00 [entrez]
PHST- 2010/01/27 06:00 [pubmed]
PHST- 2010/06/15 06:00 [medline]
AID - 10.1002/iub.307 [doi]
PST - ppublish
SO  - IUBMB Life. 2010 Apr;62(4):277-82. doi: 10.1002/iub.307.


PMID- 20101494
OWN - NLM
STAT- MEDLINE
DCOM- 20100920
LR  - 20211203
IS  - 1618-2650 (Electronic)
IS  - 1618-2642 (Linking)
VI  - 397
IP  - 5
DP  - 2010 Jul
TI  - Comparison of analytical tools and biological assays for detection of paralytic
      shellfish poisoning toxins.
PG  - 1655-71
LID - 10.1007/s00216-010-3459-4 [doi]
AB  - The paralytic shellfish poisoning toxins (PSTs) were, as their name suggests,
      discovered as a result of human poisoning after consumption of contaminated
      shellfish. More recently, however, the same toxins have been found to be produced
      by freshwater cyanobacteria. These organisms have worldwide distribution and are 
      common in our sources of drinking water, thus presenting another route of
      potential human exposure. However, the regulatory limits for PSTs in drinking
      water are considerably lower than in shellfish. This has increased the need to
      find alternatives to the mouse bioassay, which, apart from being ethically
      questionable, does not have a limit of detection capable of detecting the PSTs in
      water at the regulated concentrations. Additionally, the number of naturally
      occurring PSTs has grown substantially since saxitoxin was first characterised,
      markedly increasing the analytical challenge of this group of compounds. This
      paper summarises the development of chromatographic, toxicity, and molecular
      sensor binding methodologies for detection of the PSTs in shellfish,
      cyanobacteria, and water contaminated by these toxins. It then summarises the
      advantages and disadvantages of their use for particular applications. Finally it
      recommends some future requirements that will contribute to their improvement for
      these applications.
FAU - Humpage, A R
AU  - Humpage AR
AD  - Australian Water Quality Centre, GPO Box 1751, Adelaide, SA, 5001, Australia.
      Andrew.humpage@sawater.com.au
FAU - Magalhaes, V F
AU  - Magalhaes VF
FAU - Froscio, S M
AU  - Froscio SM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20100126
PL  - Germany
TA  - Anal Bioanal Chem
JT  - Analytical and bioanalytical chemistry
JID - 101134327
RN  - 0 (Bacterial Toxins)
RN  - 0 (Cyanobacteria Toxins)
RN  - 0 (Marine Toxins)
RN  - 0 (Microcystins)
RN  - 35523-89-8 (Saxitoxin)
SB  - IM
MH  - Animals
MH  - Bacterial Toxins/*analysis/toxicity
MH  - Biological Assay/*methods
MH  - Chemistry Techniques, Analytical/*methods
MH  - Cyanobacteria Toxins
MH  - Humans
MH  - Marine Toxins/*analysis/toxicity
MH  - Mice
MH  - Microcystins/*analysis/toxicity
MH  - Rats
MH  - Saxitoxin/*analysis/toxicity
MH  - Shellfish Poisoning/diagnosis
RF  - 124
EDAT- 2010/01/27 06:00
MHDA- 2010/09/21 06:00
CRDT- 2010/01/27 06:00
PHST- 2009/10/30 00:00 [received]
PHST- 2010/01/04 00:00 [accepted]
PHST- 2009/12/22 00:00 [revised]
PHST- 2010/01/27 06:00 [entrez]
PHST- 2010/01/27 06:00 [pubmed]
PHST- 2010/09/21 06:00 [medline]
AID - 10.1007/s00216-010-3459-4 [doi]
PST - ppublish
SO  - Anal Bioanal Chem. 2010 Jul;397(5):1655-71. doi: 10.1007/s00216-010-3459-4. Epub 
      2010 Jan 26.


PMID- 20101176
OWN - NLM
STAT- MEDLINE
DCOM- 20100421
LR  - 20211020
IS  - 1530-0293 (Electronic)
IS  - 0090-3493 (Linking)
VI  - 38
IP  - 4 Suppl
DP  - 2010 Apr
TI  - Early observational research and registries during the 2009-2010 influenza A
      pandemic.
PG  - e120-32
LID - 10.1097/CCM.0b013e3181d20c77 [doi]
AB  - As a critical care community, we have an obligation to provide not only clinical 
      care but also the research that guides initial and subsequent clinical responses 
      during a pandemic. There are many challenges to conducting such research. The
      first is speed of response. However, given the near inevitability of certain
      events, for example, viral respiratory illness such as the 2009 pandemic,
      geographically circumscribed natural disasters, or acts of terror, many study and
      trial designs should be preplanned and modified quickly when specific events
      occur. Template case report forms should be available for modification and web
      entry; centralized research ethics boards and funders should have the opportunity
      to preview and advise on such research beforehand; and national and international
      research groups should be prepared to work together on common studies and trials 
      for common challenges. We describe the early international critical care research
      response to the influenza A 2009 (H1N1) pandemic, including specifics of
      observational study case report form, registry, and clinical trial design,
      cooperation of international critical care research organizations, and the early 
      results of these collaborations.
FAU - Fowler, Robert A
AU  - Fowler RA
AD  - Canadian Critical Care Trials Group, Toronto, Ontario, Canada.
      rob.fowler@sunnybrook.ca
FAU - Webb, Steven A R
AU  - Webb SA
FAU - Rowan, Kathy M
AU  - Rowan KM
FAU - Sprung, Charles L
AU  - Sprung CL
FAU - Thompson, B Taylor
AU  - Thompson BT
FAU - Randolph, Adrienne G
AU  - Randolph AG
FAU - Jouvet, Philippe
AU  - Jouvet P
FAU - Lapinsky, Stephen
AU  - Lapinsky S
FAU - Rubinson, Lewis
AU  - Rubinson L
FAU - Rello, Jordi
AU  - Rello J
FAU - Cobb, J Perren
AU  - Cobb JP
FAU - Rice, Todd W
AU  - Rice TW
FAU - Uyeki, Tim
AU  - Uyeki T
FAU - Marshall, John C
AU  - Marshall JC
LA  - eng
GR  - U13GM083407/GM/NIGMS NIH HHS/United States
GR  - CAPMC/ CIHR/Canada
GR  - R56 AI084011/AI/NIAID NIH HHS/United States
GR  - MRC_/Medical Research Council/United Kingdom
GR  - U13 GM083407/GM/NIGMS NIH HHS/United States
GR  - HHSN268200536179C/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Crit Care Med
JT  - Critical care medicine
JID - 0355501
SB  - IM
MH  - Critical Care/organization & administration
MH  - Demography
MH  - Disease Notification/*methods
MH  - Health Services Research/*organization & administration
MH  - Health Workforce
MH  - Humans
MH  - *Influenza A Virus, H1N1 Subtype
MH  - *Influenza, Human
MH  - *Registries
MH  - Treatment Outcome
PMC - PMC3705715
MID - NIHMS389832
EDAT- 2010/01/27 06:00
MHDA- 2010/04/22 06:00
CRDT- 2010/01/27 06:00
PHST- 2010/01/27 06:00 [entrez]
PHST- 2010/01/27 06:00 [pubmed]
PHST- 2010/04/22 06:00 [medline]
AID - 10.1097/CCM.0b013e3181d20c77 [doi]
PST - ppublish
SO  - Crit Care Med. 2010 Apr;38(4 Suppl):e120-32. doi: 10.1097/CCM.0b013e3181d20c77.


PMID- 20100822
OWN - NLM
STAT- MEDLINE
DCOM- 20100513
LR  - 20100208
IS  - 1464-3685 (Electronic)
IS  - 0300-5771 (Linking)
VI  - 39
IP  - 1
DP  - 2010 Feb
TI  - Commentary: Ethics and the rhetorical context of human research.
PG  - 12-6
LID - 10.1093/ije/dyp400 [doi]
FAU - Herrera, Christopher
AU  - Herrera C
AD  - Department of Philosophy and Religion, Montclair State University, Upper
      Montclair, NJ 07043, USA. herrerach@mail.montclair.edu
LA  - eng
PT  - Comment
PT  - Journal Article
DEP - 20100125
PL  - England
TA  - Int J Epidemiol
JT  - International journal of epidemiology
JID - 7802871
SB  - IM
CON - Int J Epidemiol. 2010 Feb;39(1):7-11. PMID: 20100819
MH  - *Empirical Research
MH  - *Ethics, Research
MH  - Humans
MH  - Psychology, Social/*ethics
MH  - Research Design
EDAT- 2010/01/27 06:00
MHDA- 2010/05/14 06:00
CRDT- 2010/01/27 06:00
PHST- 2010/01/27 06:00 [entrez]
PHST- 2010/01/27 06:00 [pubmed]
PHST- 2010/05/14 06:00 [medline]
AID - dyp400 [pii]
AID - 10.1093/ije/dyp400 [doi]
PST - ppublish
SO  - Int J Epidemiol. 2010 Feb;39(1):12-6. doi: 10.1093/ije/dyp400. Epub 2010 Jan 25.


PMID- 20100753
OWN - NLM
STAT- MEDLINE
DCOM- 20100304
LR  - 20211020
IS  - 1098-4275 (Electronic)
IS  - 0031-4005 (Linking)
VI  - 125
IP  - 2
DP  - 2010 Feb
TI  - Children as hematopoietic stem cell donors.
PG  - 392-404
LID - 10.1542/peds.2009-3078 [doi]
AB  - In the past half-century, hematopoietic stem cell transplantation has become
      standard treatment for a variety of diseases in children and adults, including
      selected hematologic malignancies, immunodeficiencies, hemoglobinopathies, bone
      marrow failure syndromes, and congenital metabolic disorders. There are 3 sources
      of allogeneic hematopoietic stem cells: bone marrow, peripheral blood, and
      umbilical cord blood; each has its own benefits and risks. Children often serve
      as hematopoietic stem cell donors, most commonly for their siblings. HLA-matched 
      biological siblings are generally preferred as donors because of reduced risks of
      transplant-related complications as compared with unrelated donors. This
      statement includes a discussion of the ethical considerations regarding minors
      serving as stem cell donors, using the traditional benefit/burden calculation
      from the perspectives of both the donor and the recipient. The statement also
      includes an examination of the circumstances under which a minor may ethically
      participate as a hematopoietic stem cell donor, how the risks can be minimized,
      what the informed-consent process should entail, the role for a donor advocate
      (or some similar mechanism), and other ethical concerns. The American Academy of 
      Pediatrics holds that minors can ethically serve as stem cell donors when
      specific criteria are fulfilled.
CN  - American Academy of Pediatrics. Committee on Bioethics
LA  - eng
GR  - G13 LM009096/LM/NLM NIH HHS/United States
GR  - G13 LM009096-03/LM/NLM NIH HHS/United States
PT  - Journal Article
DEP - 20100125
PL  - United States
TA  - Pediatrics
JT  - Pediatrics
JID - 0376422
SB  - IM
MH  - Adult
MH  - Child
MH  - Cord Blood Stem Cell Transplantation
MH  - Hematopoietic Stem Cell Transplantation/*ethics/legislation &
      jurisprudence/methods/psychology/*standards
MH  - Humans
MH  - Parents/psychology
MH  - Pediatrics/ethics/standards
MH  - Reproductive Techniques, Assisted
MH  - Risk Assessment
MH  - Siblings/psychology
MH  - Tissue Donors/*ethics/psychology
MH  - United States
PMC - PMC3017470
MID - NIHMS260019
IR  - Diekema DS
FIR - Diekema, Douglas S
IR  - Fallat M
FIR - Fallat, Mary
IR  - Antommaria AH
FIR - Antommaria, Armand H Matheny
IR  - Holzman IR
FIR - Holzman, Ian R
IR  - Katz AL
FIR - Katz, Aviva L
IR  - Leuthner SR
FIR - Leuthner, Steven R
IR  - Friedman Ross L
FIR - Friedman Ross, Laine
IR  - Webb S
FIR - Webb, Sally
IR  - Baese PL
FIR - Baese, Philip L
IR  - Levetown M
FIR - Levetown, Marcia
IR  - Lyerly AD
FIR - Lyerly, Anne D
IR  - Tsai E
FIR - Tsai, Ellen
IR  - Berg JW
FIR - Berg, Jessica W
IR  - Baker A
FIR - Baker, Alison
EDAT- 2010/01/27 06:00
MHDA- 2010/03/05 06:00
CRDT- 2010/01/27 06:00
PHST- 2010/01/27 06:00 [entrez]
PHST- 2010/01/27 06:00 [pubmed]
PHST- 2010/03/05 06:00 [medline]
AID - peds.2009-3078 [pii]
AID - 10.1542/peds.2009-3078 [doi]
PST - ppublish
SO  - Pediatrics. 2010 Feb;125(2):392-404. doi: 10.1542/peds.2009-3078. Epub 2010 Jan
      25.


PMID- 20100618
OWN - NLM
STAT- MEDLINE
DCOM- 20100401
LR  - 20100301
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 93
IP  - 4
DP  - 2010 Mar 1
TI  - Unique ethical and legal implications of fertility preservation research in the
      pediatric population.
PG  - 1037-9
LID - 10.1016/j.fertnstert.2009.11.047 [doi]
AB  - Research in fertility preservation for children and adolescents receiving
      gonadotoxic chemotherapy has brought forth ethical and legal concerns that
      require special consideration. This article will discuss many of these issues and
      possible methods to safeguard the rights of these children.
CI  - Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier 
      Inc. All rights reserved.
FAU - Stegmann, Barbara J
AU  - Stegmann BJ
LA  - eng
PT  - Editorial
DEP - 20100125
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Child
MH  - *Fertility
MH  - Humans
MH  - Infertility/chemically induced/*prevention & control
MH  - Informed Consent/ethics/legislation & jurisprudence
MH  - Pediatrics/*ethics/legislation & jurisprudence
MH  - Religion
MH  - Research Subjects/legislation & jurisprudence
EDAT- 2010/01/27 06:00
MHDA- 2010/04/02 06:00
CRDT- 2010/01/27 06:00
PHST- 2009/08/27 00:00 [received]
PHST- 2009/11/20 00:00 [revised]
PHST- 2009/11/27 00:00 [accepted]
PHST- 2010/01/27 06:00 [entrez]
PHST- 2010/01/27 06:00 [pubmed]
PHST- 2010/04/02 06:00 [medline]
AID - S0015-0282(09)04132-6 [pii]
AID - 10.1016/j.fertnstert.2009.11.047 [doi]
PST - ppublish
SO  - Fertil Steril. 2010 Mar 1;93(4):1037-9. doi: 10.1016/j.fertnstert.2009.11.047.
      Epub 2010 Jan 25.


PMID- 20100289
OWN - NLM
STAT- MEDLINE
DCOM- 20100910
LR  - 20100507
IS  - 1447-0594 (Electronic)
IS  - 1447-0594 (Linking)
VI  - 10
IP  - 2
DP  - 2010 Apr
TI  - Would the elderly be better off if they were given more placebos?
PG  - 131-7
LID - 10.1111/j.1447-0594.2009.00580.x [doi]
AB  - Placebos are useful in the medical care of the elderly, although the exact
      definition of a "placebo" or "placebo effect" is difficult to define precisely.
      They have an important role as control treatments in research trials, but a
      non-specific "placebo effect" may also be beneficial part of many
      physician-patient interactions. Physicians also give them deliberately according 
      to several studies worldwide to satisfy patient demands or because they believe
      in a "placebo effect" among other reasons. A significant placebo effect has been 
      observed among older patients in clinical trials of antidepressants (12-15%), and
      in treatments of Parkinson's disease (16%). Placebos activate serotonergic
      pathways in the brain used by antidepressants. In Parkinson's disease, the
      administration of a placebo stimulates dopamine release in the dorsal (resulting 
      in motor effects) and ventral striatum (which influences expectation of reward). 
      Much of our understanding of the placebo effect comes from studies of placebo
      analgesia which is influenced by conditioning, expectation, meaning and context
      of the treatment for the patient, and patient-physician interaction. It is
      anatomically medicated by brain opioid pathways. Response to "sham" acupuncture
      in osteoarthritis may be an example of its use in the elderly. Placebos have
      often been considered a deception and thus unethical. On the other hand, some
      physicians and ethicists have suggested conditions for appropriate uses for
      placebos. A placebo might offer the theoretical advantage of an inexpensive
      treatment that would not cause adverse drug reactions or interactions with other 
      medications, potentially avoiding complications of polypharmacy.
FAU - Cherniack, E Paul
AU  - Cherniack EP
AD  - The Geriatrics Institute, University of Miami Miller School of Medicine, Division
      of Geriatrics and Gerontology, and the Geriatrics and Extended Care Service and
      Geriatric Research Education, and Clinical Center of Miami Veterans Affairs
      Medical Center, Miami, Florida 33125, USA. evan.cherniack@va.gov
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100119
PL  - Japan
TA  - Geriatr Gerontol Int
JT  - Geriatrics & gerontology international
JID - 101135738
RN  - 0 (Placebos)
SB  - IM
MH  - Aged, 80 and over
MH  - Ethics, Research
MH  - Humans
MH  - Physician-Patient Relations/ethics
MH  - *Placebo Effect
MH  - Placebos/*therapeutic use
RF  - 62
EDAT- 2010/01/27 06:00
MHDA- 2010/09/11 06:00
CRDT- 2010/01/27 06:00
PHST- 2010/01/27 06:00 [entrez]
PHST- 2010/01/27 06:00 [pubmed]
PHST- 2010/09/11 06:00 [medline]
AID - GGI580 [pii]
AID - 10.1111/j.1447-0594.2009.00580.x [doi]
PST - ppublish
SO  - Geriatr Gerontol Int. 2010 Apr;10(2):131-7. doi:
      10.1111/j.1447-0594.2009.00580.x. Epub 2010 Jan 19.


PMID- 20099341
OWN - NLM
STAT- MEDLINE
DCOM- 20100415
LR  - 20131121
IS  - 1522-2586 (Electronic)
IS  - 1053-1807 (Linking)
VI  - 31
IP  - 2
DP  - 2010 Feb
TI  - Blood-oxygen level dependent MRI measures of cerebrovascular reactivity using a
      controlled respiratory challenge: reproducibility and gender differences.
PG  - 298-304
LID - 10.1002/jmri.22044 [doi]
AB  - PURPOSE: To evaluate the reproducibility and gender differences in
      cerebrovascular reactivity (CVR) measurements obtained using the blood-oxygen
      level dependent (BOLD) response to controlled changes in end-tidal partial
      pressure of carbon dioxide (PETCO(2)). MATERIALS AND METHODS: We obtained ethical
      approval to image 19 healthy volunteers (10 men, 9 women) on a 1.5 Tesla (T) MRI 
      scanner twice on two separate days using identical procedures. CVR images were
      generated by collecting BOLD MRI data during controlled changes in PETCO(2)
      induced by a sequential gas delivery system. RESULTS: Using the intraclass
      correlation coefficient (ICC), we demonstrated excellent within-day CVR measures 
      in gray matter (GM) (ICC = 0.92) and white matter (WM) (ICC = 0.88) regions,
      excellent between-day reproducibility in GM (ICC = 0.81), and good between-day
      reproducibility in the WM (ICC = 0.66). CVR values between men and women were
      significantly different in the GM and WM. Men exhibited a 22 +/- 2% greater CVR
      in GM and a 17 +/- 2% greater CVR in WM compared with females. CONCLUSION: Our
      results demonstrate the reliability of BOLD MRI CVR measurements obtained using a
      controlled cerebrovascular challenge. Using this technique, we also revealed
      significantly increased BOLD response to CO(2) in males compared with females.
FAU - Kassner, Andrea
AU  - Kassner A
AD  - Department of Physiology and Experimental Medicine, The Hospital for Sick
      Children, Toronto, Ontario, Canada. andrea.kassner@utoronto.ca
FAU - Winter, Jeff D
AU  - Winter JD
FAU - Poublanc, Julien
AU  - Poublanc J
FAU - Mikulis, David J
AU  - Mikulis DJ
FAU - Crawley, Adrian P
AU  - Crawley AP
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
RN  - 142M471B3J (Carbon Dioxide)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Blood Flow Velocity/drug effects/*physiology
MH  - Brain/blood supply/drug effects/*physiology
MH  - Carbon Dioxide/*administration & dosage
MH  - Cerebrovascular Circulation/drug effects/*physiology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Oxygen/*metabolism
MH  - Pulmonary Gas Exchange/drug effects/*physiology
MH  - Sex Factors
MH  - Vasodilation/drug effects/physiology
EDAT- 2010/01/26 06:00
MHDA- 2010/04/16 06:00
CRDT- 2010/01/26 06:00
PHST- 2010/01/26 06:00 [entrez]
PHST- 2010/01/26 06:00 [pubmed]
PHST- 2010/04/16 06:00 [medline]
AID - 10.1002/jmri.22044 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2010 Feb;31(2):298-304. doi: 10.1002/jmri.22044.


PMID- 20098845
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20190606
IS  - 1414-431X (Electronic)
IS  - 0100-879X (Linking)
VI  - 43
IP  - 2
DP  - 2010 Feb
TI  - Ethical research as the target of animal extremism: an international problem.
PG  - 124-6
LID - S0100-879X2010005000006 [pii]
AB  - Animal extremism has been increasing worldwide; frequently researchers are the
      targets of actions by groups with extreme animal rights agendas. Sometimes this
      targeting is violent and may involve assaults on family members or destruction of
      property. In this article, we summarize recent events and suggest steps that
      researchers can take to educate the public on the value of animal research both
      for people and animals.
FAU - Conn, P Michael
AU  - Conn PM
AD  - Office of Research Advocacy, Oregon Health and Science University, Beaverton, OR,
      USA.
FAU - Rantin, F T
AU  - Rantin FT
LA  - eng
PT  - Journal Article
DEP - 20100122
PL  - Brazil
TA  - Braz J Med Biol Res
JT  - Brazilian journal of medical and biological research = Revista brasileira de
      pesquisas medicas e biologicas
JID - 8112917
SB  - IM
MH  - Animal Care Committees
MH  - Animal Experimentation/*ethics/legislation & jurisprudence
MH  - Animal Rights/*legislation & jurisprudence
MH  - Animals
MH  - Biomedical Research/*ethics/legislation & jurisprudence
MH  - Humans
MH  - Internationality
MH  - Violence/*prevention & control
EDAT- 2010/01/26 06:00
MHDA- 2010/09/15 06:00
CRDT- 2010/01/26 06:00
PHST- 2009/09/12 00:00 [received]
PHST- 2010/01/07 00:00 [accepted]
PHST- 2010/01/26 06:00 [entrez]
PHST- 2010/01/26 06:00 [pubmed]
PHST- 2010/09/15 06:00 [medline]
AID - S0100-879X2010005000006 [pii]
AID - 10.1590/s0100-879x2010005000006 [doi]
PST - ppublish
SO  - Braz J Med Biol Res. 2010 Feb;43(2):124-6. doi: 10.1590/s0100-879x2010005000006. 
      Epub 2010 Jan 22.


PMID- 20098325
OWN - NLM
STAT- MEDLINE
DCOM- 20100720
LR  - 20100310
IS  - 1473-656X (Electronic)
IS  - 1040-872X (Linking)
VI  - 22
IP  - 2
DP  - 2010 Apr
TI  - Ethical challenges in providing noninvasive prenatal diagnosis.
PG  - 128-34
LID - 10.1097/GCO.0b013e3283372352 [doi]
AB  - PURPOSE OF REVIEW: Noninvasive prenatal diagnosis (NIPD) can potentially allow
      early detection of fetal genetic disorders, sex, other nonmedical traits, and
      paternity. We review ethical concerns associated with the imminent introduction
      of this testing. RECENT FINDINGS: There has been inadequate scientific and
      medical review of some NIPD tests under development or already available as
      direct-to-consumer products. Test introduction is largely unregulated and this
      has prompted calls for greater oversight. As a replacement for current prenatal
      screening and diagnosis, NIPD may not necessarily identify the same spectrum of
      disorders. Ethicists are also concerned how women can receive adequate pretest
      counseling and provide a truly informed consent. Widespread use of NIPD for minor
      disorders, predispositions, sex, normal human variation and paternity could
      result in a trivialization of pregnancy termination. Other concerns include the
      equitable access to testing by all population subgroups. NIPD has the potential
      to significantly reduce the prevalence of some genetic disorders and thereby
      change public attitudes about the handicapped and their families. SUMMARY:
      Striking the correct balance between providing only worthwhile testing and
      ensuring individual patients' reproductive choice will be a major challenge and
      it is important to begin to address the many ethical issues that NIPD raises.
FAU - Benn, Peter A
AU  - Benn PA
AD  - Department of Genetics and Developmental Biology, Division of Human Genetics,
      USA. Benn@nso1.uchc.edu
FAU - Chapman, Audrey R
AU  - Chapman AR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Curr Opin Obstet Gynecol
JT  - Current opinion in obstetrics & gynecology
JID - 9007264
SB  - IM
MH  - Consumer Health Information/ethics
MH  - Female
MH  - Genetic Counseling/ethics
MH  - *Genetic Testing
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Maternal-Fetal Exchange
MH  - Pregnancy
MH  - Prenatal Diagnosis/*ethics
RF  - 36
EDAT- 2010/01/26 06:00
MHDA- 2010/07/21 06:00
CRDT- 2010/01/26 06:00
PHST- 2010/01/26 06:00 [entrez]
PHST- 2010/01/26 06:00 [pubmed]
PHST- 2010/07/21 06:00 [medline]
AID - 10.1097/GCO.0b013e3283372352 [doi]
PST - ppublish
SO  - Curr Opin Obstet Gynecol. 2010 Apr;22(2):128-34. doi:
      10.1097/GCO.0b013e3283372352.


PMID- 20098191
OWN - NLM
STAT- MEDLINE
DCOM- 20100504
LR  - 20100125
IS  - 1536-3732 (Electronic)
IS  - 1049-2275 (Linking)
VI  - 21
IP  - 1
DP  - 2010 Jan
TI  - Relationship between palm flexion lines and craniofacial profile structure in
      adults.
PG  - 252-7
LID - 10.1097/SCS.0b013e3181c5a2b5 [doi]
AB  - OBJECTIVES: The analysis and evaluation of the craniofacial profile structure and
      dermatoglyphic structures are a research subject particularly significant for the
      scientific areas of anatomy, anthropology, genetics, and criminology. Relevant
      studies show that both the craniofacial structure and dermatoglyphic structures
      carry genetic features and show their details. The aim of this study was to
      analyze the relationship between palm flexion line types in individuals and
      craniofacial morphologic structure. The link between these 2 significant genetic 
      characteristics has been studied. METHODS: This research was done the Department 
      of Anatomy in Eskisehir Osmangazi University in 2002. During the study, the whole
      essential and ethics conditions have been done.This study has been carried out on
      170 individuals: 87 women and 83 men. Photographic analysis was used to take
      facial profiles and palm lines of the individuals in the research sample. Muzj
      and Ricketts soft-tissue analyses were used to identify the craniofacial type.
      Diversification of palm flexion line types were classified for the individuals
      whose craniofacial types were identified. RESULTS: No relationship was observed
      between the profile structures classified as linear and angular according to Muzj
      method and flexion line types in the right and left hands. Also, there was no
      relationship observed between the labium superior and labium inferior values of
      the individuals, the distance of which to E line was calculated according to the 
      Ricketts method and the flexion line types in the right and left hands.
      CONCLUSIONS: No precise relationship was found in the same individuals between
      the craniofacial morphologic structure and palm flexion line types.
FAU - Burukoglu, Dilek
AU  - Burukoglu D
AD  - Department of Histology and Embryology, Faculty of Medicine, Eskisehir Osmangazi 
      University, Eskisehir, Turkey. dburukoglu@yahoo.com
FAU - Ortug, Gursel
AU  - Ortug G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Craniofac Surg
JT  - The Journal of craniofacial surgery
JID - 9010410
MH  - Adult
MH  - *Dermatoglyphics
MH  - Face/*anatomy & histology
MH  - Female
MH  - Humans
MH  - Male
MH  - Photography
MH  - ROC Curve
EDAT- 2010/01/26 06:00
MHDA- 2010/05/05 06:00
CRDT- 2010/01/26 06:00
PHST- 2010/01/26 06:00 [entrez]
PHST- 2010/01/26 06:00 [pubmed]
PHST- 2010/05/05 06:00 [medline]
AID - 10.1097/SCS.0b013e3181c5a2b5 [doi]
AID - 00001665-201001000-00058 [pii]
PST - ppublish
SO  - J Craniofac Surg. 2010 Jan;21(1):252-7. doi: 10.1097/SCS.0b013e3181c5a2b5.


PMID- 20097420
OWN - NLM
STAT- MEDLINE
DCOM- 20100503
LR  - 20100209
IS  - 1873-7757 (Electronic)
IS  - 0145-2134 (Linking)
VI  - 34
IP  - 1
DP  - 2010 Jan
TI  - Monitoring the commitment and child-friendliness of governments: a new approach
      from Africa.
PG  - 34-44
LID - 10.1016/j.chiabu.2009.08.007 [doi]
AB  - OBJECTIVE: The Convention on the Rights of the Child (CRC) is generally viewed
      from an ethical perspective, specifically for its influence and impact on our
      ethos and the place of children in society. A recent ground-breaking report
      prepared by The African Child Policy Forum (ACPF) shows conceptually and
      empirically how the CRC can be used as a tool for planning national action and
      for monitoring government performance and compliance. This paper reports on the
      methodology followed, the philosophical and legal foundations, the results of the
      application and the policy lessons. METHOD: This work is based on a methodology, 
      the Child-Friendliness Index (CFI), developed by ACPF to analyse and monitor the 
      performance of all 52 African governments. The index is inspired by the CRC's
      three core principles-Protection, Provision and Participation-and based on over
      forty policy and child-outcome indicators. RESULTS: The methodology was applied
      to organise data, assess performance and score and rank all 52 African
      governments at a point in time and over time. On this basis, the study identifies
      which governments are child-friendly and which ones are not and why, and what it 
      is that poorly performing governments can do to comply with their international
      obligations. CONCLUSIONS: Two important conclusions emerge from this exercise.
      The first is the beauty and power of simplicity. Much analysis of government
      obligations is hampered by the tedious task of having to scan voluminous
      information and bulky reports. But this CRC-inspired and CRC-based methodology
      provides a simple but powerful, transparent and objective framework for policy
      analysis and comparison. Secondly, the African experience confirms that three
      things matter on the policy front: politics that put children at the centre of
      public policy; Laws that protect them; and Budgets that provide for their basic
      needs and full development. PRACTICAL IMPLICATIONS: ACPF's work provides an
      approach that governments, advocacy groups and treaty bodies can use to monitor
      government compliance, to identify areas for progress and to formulate effective 
      pro-children policies. The approach is important and relevant for other regions
      of the world as it is for Africa.
CI  - Copyright (c) 2009 Elsevier Ltd. All rights reserved.
FAU - Bequele, Assefa
AU  - Bequele A
AD  - The African Child Policy Forum, Addis Ababa, Ethiopia.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20100125
PL  - England
TA  - Child Abuse Negl
JT  - Child abuse & neglect
JID - 7801702
SB  - IM
MH  - Africa
MH  - Child
MH  - Child Abuse/*legislation & jurisprudence/*prevention & control
MH  - Child Welfare/*legislation & jurisprudence
MH  - Cross-Cultural Comparison
MH  - *Developing Countries
MH  - *Government Regulation
MH  - Humans
MH  - Public Policy/*legislation & jurisprudence
MH  - Social Conditions
MH  - Social Problems/legislation & jurisprudence/prevention & control
MH  - Social Values
MH  - United Nations
EDAT- 2010/01/26 06:00
MHDA- 2010/05/04 06:00
CRDT- 2010/01/26 06:00
PHST- 2009/07/31 00:00 [received]
PHST- 2009/08/13 00:00 [accepted]
PHST- 2010/01/26 06:00 [entrez]
PHST- 2010/01/26 06:00 [pubmed]
PHST- 2010/05/04 06:00 [medline]
AID - S0145-2134(09)00260-9 [pii]
AID - 10.1016/j.chiabu.2009.08.007 [doi]
PST - ppublish
SO  - Child Abuse Negl. 2010 Jan;34(1):34-44. doi: 10.1016/j.chiabu.2009.08.007. Epub
      2010 Jan 25.


PMID- 20097414
OWN - NLM
STAT- MEDLINE
DCOM- 20100531
LR  - 20141120
IS  - 1879-3231 (Electronic)
IS  - 0093-691X (Linking)
VI  - 73
IP  - 6
DP  - 2010 Apr 1
TI  - Modeling the interaction of gametes and embryos with the maternal genital tract: 
      from in vivo to in silico.
PG  - 828-37
LID - 10.1016/j.theriogenology.2010.01.001 [doi]
AB  - Understanding the complex interaction between gametes or embryos and the maternal
      genital tract requires the use of experimental models. The selection of the right
      model is an important task to undertake, and despite many new developments in
      this area, an ideal model system has not yet been developed. In this review
      article, we focus on how the most appropriate model species and model system can 
      be selected, each with its particular advantages and disadvantages. Selection
      criteria need to be based on the evaluation of the aim of the experiment, the
      tools that are available to the scientist, and the ethics that are involved in
      working with particular animal species and model systems. Society and politics
      direct scientists to "Refine, Reduce, and Replace" the use of experimental
      animals, which means that the use of in vivo models is increasingly being
      discouraged. An in vivo model allows experimentation in the full biological
      environment of a living organism. In contrast with in vivo models, in vitro
      models are less complex and are abstracts of in vivo systems, leading often to
      results that are different from the in vivo situation. If an investigator could
      understand all the components of a complex biological system and re-create them
      as individual smaller models in a computer, he or she could create in silico
      models that would completely represent the complexity of in vivo models. We
      predict that in the future, in silico modeling will be the natural departure from
      in vivo, in situ, and in vitro modeling approaches. In addition to numerous
      advantages that this modeling approach can bring to studying maternal interaction
      with gametes and embryo, it is perhaps the only true alternative method to animal
      experimentation.
CI  - 2010 Elsevier Inc. All rights reserved.
FAU - Van Soom, A
AU  - Van Soom A
AD  - Reproductive Biology Unit, Department of Reproduction, Obstetrics and Herd
      Health, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
      ann.vansoom@Ugent.be
FAU - Vandaele, L
AU  - Vandaele L
FAU - Peelman, L J
AU  - Peelman LJ
FAU - Goossens, K
AU  - Goossens K
FAU - Fazeli, A
AU  - Fazeli A
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100125
PL  - United States
TA  - Theriogenology
JT  - Theriogenology
JID - 0421510
SB  - IM
MH  - Animal Welfare/ethics
MH  - Animals
MH  - Bioethical Issues
MH  - Embryonic Development/*physiology
MH  - Female
MH  - *Genitalia, Female
MH  - Humans
MH  - In Vitro Techniques
MH  - Male
MH  - Models, Animal
MH  - *Models, Biological
MH  - Oocytes/*physiology
MH  - Pregnancy
MH  - Spermatozoa/*physiology
RF  - 44
EDAT- 2010/01/26 06:00
MHDA- 2010/06/01 06:00
CRDT- 2010/01/26 06:00
PHST- 2009/11/24 00:00 [received]
PHST- 2009/12/11 00:00 [accepted]
PHST- 2010/01/26 06:00 [entrez]
PHST- 2010/01/26 06:00 [pubmed]
PHST- 2010/06/01 06:00 [medline]
AID - S0093-691X(10)00021-X [pii]
AID - 10.1016/j.theriogenology.2010.01.001 [doi]
PST - ppublish
SO  - Theriogenology. 2010 Apr 1;73(6):828-37. doi:
      10.1016/j.theriogenology.2010.01.001. Epub 2010 Jan 25.


PMID- 20096839
OWN - NLM
STAT- MEDLINE
DCOM- 20101101
LR  - 20100708
IS  - 1873-491X (Electronic)
IS  - 0020-7489 (Linking)
VI  - 47
IP  - 8
DP  - 2010 Aug
TI  - Restoring embodied control following surgical treatment for colorectal cancer: a 
      longitudinal qualitative study.
PG  - 946-56
LID - 10.1016/j.ijnurstu.2009.12.008 [doi]
AB  - BACKGROUND: This article presents the findings of a study about recovery
      following surgery for colorectal cancer. Most patients diagnosed with this cancer
      are treated with surgery. Few studies have employed a qualitative approach to
      examine their experiences and perceptions of recovering from this treatment.
      OBJECTIVES: The purpose of this study was to discover the process of recovery for
      individuals following curative surgery for colorectal cancer. DESIGN: This
      qualitative study drew on grounded theory methods and used a prospective
      longitudinal design. SETTINGS: Ethical approval was granted by three Local
      Research Ethics Committees enabling patients to be recruited from three different
      hospitals in the South of England. PARTICIPANTS: Purposive sampling was used to
      identify patients diagnosed with colorectal cancer who had had surgery with
      curative intent. METHODS: Each participant was interviewed up to four times
      following their surgery: at 6 weeks then at 3, 6 and 12 months. Sixty-two
      interviews were conducted. Emerging concepts from the analysis defined further
      data collection. Relevant literature was theoretically sampled and all data
      analysed using constant comparison. Theoretical saturation was achieved. RESULTS:
      Sixteen participants were recruited. Analysis of study data identified four
      conceptual stages representing the main phases individuals can experience during 
      their recovery. They are: disembodiment, restoring embodiment, reclaiming control
      and managing embodied control. These occur in a stepwise progression, reflecting 
      the emotional, physical and social processes involved in restoring perceived
      control over the body. They reflect the difficulty individuals can experience in 
      understanding and self-managing their bodies. There is a desire to regain
      confidence and certainty over body function but this is threatened by fears about
      future health. CONCLUSIONS: Achieving a sense of control of one's body, after
      surgery for colorectal cancer, proves to be a major challenge. Greater
      recognition of the consequences of cancer and its treatment upon the body and
      individualised management is required. Addressing how individuals can regain
      embodied control during their recovery needs to be integral within post-treatment
      support.
CI  - Copyright (c) 2009 Elsevier Ltd. All rights reserved.
FAU - Taylor, Claire
AU  - Taylor C
AD  - Kings College, London, Florence Nightingale School of Nursing and Midwifery,
      Burdett Institute, St Marks' Hospital, Harrow HA1 3UJ, United Kingdom.
      gillian.taylor@kcl.ac.uk
FAU - Richardson, Alison
AU  - Richardson A
FAU - Cowley, Sarah
AU  - Cowley S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100122
PL  - England
TA  - Int J Nurs Stud
JT  - International journal of nursing studies
JID - 0400675
SB  - IM
MH  - Colorectal Neoplasms/*psychology/surgery
MH  - Humans
MH  - Longitudinal Studies
EDAT- 2010/01/26 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/01/26 06:00
PHST- 2009/02/02 00:00 [received]
PHST- 2009/12/17 00:00 [revised]
PHST- 2009/12/18 00:00 [accepted]
PHST- 2010/01/26 06:00 [entrez]
PHST- 2010/01/26 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - S0020-7489(09)00400-3 [pii]
AID - 10.1016/j.ijnurstu.2009.12.008 [doi]
PST - ppublish
SO  - Int J Nurs Stud. 2010 Aug;47(8):946-56. doi: 10.1016/j.ijnurstu.2009.12.008. Epub
      2010 Jan 22.


PMID- 20096822
OWN - NLM
STAT- MEDLINE
DCOM- 20100419
LR  - 20100402
IS  - 1879-1883 (Electronic)
IS  - 0002-9610 (Linking)
VI  - 199
IP  - 4
DP  - 2010 Apr
TI  - Moral angst for surgical residents: a qualitative study.
PG  - 571-6
LID - 10.1016/j.amjsurg.2009.04.007 [doi]
AB  - BACKGROUND: The ethical dilemmas that residents experience throughout their
      training have not been explored qualitatively from surgical residents'
      perspectives. METHODS: Grounded theory methodology was used. All University of
      Toronto surgical, otolaryngology, and obstetrics and gynecology residents were
      invited to participate. Twenty-eight face-to-face interviews were conducted.
      Interviews were transcribed and analyzed by 3 reviewers. RESULTS: Five
      encompassing themes emerged: (1) residents prefer operating with another resident
      while the staff watches; (2) residents felt that patients were rarely well
      informed about their role; (3) residents develop good relationships with
      patients; (4) residents felt ethically obliged to disclose intraoperative errors;
      and (5) residents experience ethical distress in certain teaching circumstances. 
      CONCLUSIONS: Residents encounter ethical dilemmas leading to moral angst during
      their surgical training and need to feel safe to discuss these openly. Staff and 
      residents should work together to establish optimal communication and teaching
      situations.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Knifed, Eva
AU  - Knifed E
AD  - Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada.
FAU - Goyal, Aunshu
AU  - Goyal A
FAU - Bernstein, Mark
AU  - Bernstein M
LA  - eng
PT  - Journal Article
DEP - 20100122
PL  - United States
TA  - Am J Surg
JT  - American journal of surgery
JID - 0370473
SB  - IM
CIN - Am J Surg. 2010 Apr;199(4):577-9. PMID: 20359577
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Clinical Competence
MH  - Female
MH  - Gynecology/education
MH  - Humans
MH  - *Internship and Residency/ethics
MH  - Interprofessional Relations
MH  - Male
MH  - Medical Errors/ethics
MH  - *Moral Obligations
MH  - Narration
MH  - Obstetrics/education
MH  - Ontario
MH  - Otolaryngology/education
MH  - *Physician-Patient Relations/ethics
MH  - Qualitative Research
MH  - Research Design
MH  - Sample Size
MH  - Specialties, Surgical/*education/*ethics
MH  - *Students, Medical/psychology
MH  - Teaching/methods
MH  - Truth Disclosure/ethics
EDAT- 2010/01/26 06:00
MHDA- 2010/04/20 06:00
CRDT- 2010/01/26 06:00
PHST- 2009/02/27 00:00 [received]
PHST- 2009/04/03 00:00 [revised]
PHST- 2009/04/06 00:00 [accepted]
PHST- 2010/01/26 06:00 [entrez]
PHST- 2010/01/26 06:00 [pubmed]
PHST- 2010/04/20 06:00 [medline]
AID - S0002-9610(09)00305-5 [pii]
AID - 10.1016/j.amjsurg.2009.04.007 [doi]
PST - ppublish
SO  - Am J Surg. 2010 Apr;199(4):571-6. doi: 10.1016/j.amjsurg.2009.04.007. Epub 2010
      Jan 22.


PMID- 20096713
OWN - NLM
STAT- MEDLINE
DCOM- 20101012
LR  - 20141120
IS  - 1873-507X (Electronic)
IS  - 0031-9384 (Linking)
VI  - 100
IP  - 3
DP  - 2010 Jun 1
TI  - Impact of anabolic androgenic steroids on adolescent males.
PG  - 199-204
LID - 10.1016/j.physbeh.2010.01.007 [doi]
AB  - Anabolic androgenic steroid (AAS) use increased dramatically among adolescent
      males. This review focuses on studies using animal models of AAS exposure during 
      adolescence which is a hormonally sensitive developmental period. AAS exposure
      during this critical period has wide-ranging consequences, including increased
      dendritic spine density, altered brain serotonin levels and escalated aggression 
      in response to physical provocation. Human data suggest that AAS induces
      indiscriminate and unprovoked aggression often described as "'roid rage".
      However, animal studies indicate that the behavioral impact of AAS is modulated
      by experiential and social contingencies, a perceived provocation, and the
      chemical composition of the AAS. The AAS, testosterone increases aggression in
      juvenile and adult male rats when physically provoked. In contrast, stanzolol,
      inhibits aggression in both juvenile and adult male rats, even when physically
      provoked. Nandrolone has minimal effects on aggression, unless preceded by attack
      training. Exposure to AAS during adolescence may have a host of unintended
      bio-behavioral consequences. Yet, the perception of harmlessness surrounds AAS
      use. The perception of harmlessness is promoted by the availability of AAS
      especially through internet pharmacies. The perception of acceptability is
      reflected in current cultural ethics that no longer condemn cheating to obtain
      personal achievement or success. A prevailing conviction is that although AAS are
      illegal they are not really bad. Reduction of the availability of AAS to
      adolescents requires ardent legislative and legal intervention. The problem of
      acceptability can be addressed by educating adolescents about the short-term and 
      long-term effects of AAS on brain and behavior, to increase awareness of the
      potential consequences of AAS use that apply directly to them.
CI  - Published by Elsevier Inc.
FAU - Lumia, Augustus R
AU  - Lumia AR
AD  - Department of Pharmacology, University of Texas Health Science Center at San
      Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, United States.
FAU - McGinnis, Marilyn Y
AU  - McGinnis MY
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100122
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Anabolic Agents)
RN  - 0 (Androgens)
RN  - 333DO1RDJY (Serotonin)
RN  - 3XMK78S47O (Testosterone)
RN  - 6PG9VR430D (Nandrolone)
SB  - IM
MH  - Adolescent
MH  - Adolescent Behavior/*drug effects/psychology
MH  - Adult
MH  - Age Factors
MH  - Aggression/drug effects/psychology
MH  - Anabolic Agents/*adverse effects
MH  - Androgens/*adverse effects
MH  - Animals
MH  - Brain/*drug effects/metabolism
MH  - Dendritic Spines/drug effects
MH  - Humans
MH  - Male
MH  - Nandrolone/*adverse effects
MH  - Psychology, Adolescent
MH  - Rats
MH  - Serotonin/metabolism
MH  - Social Behavior
MH  - Testosterone/*adverse effects
MH  - Time Factors
EDAT- 2010/01/26 06:00
MHDA- 2010/10/13 06:00
CRDT- 2010/01/26 06:00
PHST- 2009/11/04 00:00 [received]
PHST- 2009/12/03 00:00 [revised]
PHST- 2010/01/12 00:00 [accepted]
PHST- 2010/01/26 06:00 [entrez]
PHST- 2010/01/26 06:00 [pubmed]
PHST- 2010/10/13 06:00 [medline]
AID - S0031-9384(10)00020-X [pii]
AID - 10.1016/j.physbeh.2010.01.007 [doi]
PST - ppublish
SO  - Physiol Behav. 2010 Jun 1;100(3):199-204. doi: 10.1016/j.physbeh.2010.01.007.
      Epub 2010 Jan 22.


PMID- 20096413
OWN - NLM
STAT- MEDLINE
DCOM- 20100610
LR  - 20220409
IS  - 1873-491X (Electronic)
IS  - 0020-7489 (Linking)
VI  - 47
IP  - 5
DP  - 2010 May
TI  - Nurses' ethical reasoning and behaviour: a literature review.
PG  - 635-50
LID - 10.1016/j.ijnurstu.2009.12.010 [doi]
AB  - BACKGROUND: Today's healthcare system requires that nurses have strong
      medical-technical competences and the ability to focus on the ethical dimension
      of care. For nurses, coping with the ethical dimension of care in practise is
      very difficult. Often nurses cannot act according to their own personal values
      and norms. This generates internal moral distress, which has a negative impact on
      both nurses and patients. OBJECTIVES: The objective of this review is a thorough 
      analysis of the literature about nurses' ethical practise particularly with
      regard to their processes of ethical reasoning and decision making and
      implementation of those decisions in practise. DESIGN: We conducted an extensive 
      search of the electronic databases Medline, Embase, Cinahl, and PsycInfo for
      papers published between January 1988 and September 2008. A broad range of search
      keywords was used. The 39 selected articles had a quantitative, qualitative, or
      mixed-method design. FINDINGS: Despite the conceptual difficulties that the
      literature on the ethical practise of nurses suffers, in this review we
      understand nurses' ethical practise a complex process of reasoning, decision
      making, and implementation of the decision in practise. The process of decision
      making is more than a pure cognitive process; it is influenced by personal and
      contextual factors. The difficulties nurses encounter in their ethical conduct
      are linked to their difficult work environment. As a result, nurses often
      capitulate to the decisions made by others, which results in a conformist way of 
      acting and less individually adapted care. CONCLUSIONS: This review provides us
      with a more nuanced understanding of the way nurses reason and act in ethically
      difficult situations than emerged previously. If we want to support nurses in
      their ethical care and if we want to help them to change their conformist
      practises, more research is needed. Especially needed are in-depth qualitative
      studies that explore the experiences of nurses. Such studies could help us better
      understand not only how nurses reason and behave in practise but also the
      relationship between these two processes.
CI  - Copyright 2010 Elsevier Ltd. All rights reserved.
FAU - Goethals, Sabine
AU  - Goethals S
AD  - Catholic University College Ghent, Department of Nursing, Hospitaalstraat 23,
      9100 Sint-Niklaas, Belgium. sabine.goethals@kahosl.be
FAU - Gastmans, Chris
AU  - Gastmans C
FAU - de Casterle, Bernadette Dierckx
AU  - de Casterle BD
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100121
PL  - England
TA  - Int J Nurs Stud
JT  - International journal of nursing studies
JID - 0400675
SB  - IM
MH  - *Decision Making
MH  - *Ethics, Nursing
MH  - Nurses/*psychology
RF  - 86
EDAT- 2010/01/26 06:00
MHDA- 2010/06/11 06:00
CRDT- 2010/01/26 06:00
PHST- 2009/07/16 00:00 [received]
PHST- 2009/11/04 00:00 [revised]
PHST- 2009/12/18 00:00 [accepted]
PHST- 2010/01/26 06:00 [entrez]
PHST- 2010/01/26 06:00 [pubmed]
PHST- 2010/06/11 06:00 [medline]
AID - S0020-7489(09)00402-7 [pii]
AID - 10.1016/j.ijnurstu.2009.12.010 [doi]
PST - ppublish
SO  - Int J Nurs Stud. 2010 May;47(5):635-50. doi: 10.1016/j.ijnurstu.2009.12.010. Epub
      2010 Jan 21.


PMID- 20096357
OWN - NLM
STAT- MEDLINE
DCOM- 20100817
LR  - 20100503
IS  - 1095-953X (Electronic)
IS  - 0969-9961 (Linking)
VI  - 38
IP  - 3
DP  - 2010 Jun
TI  - Update on deep brain stimulation for neuropsychiatric disorders.
PG  - 346-53
LID - 10.1016/j.nbd.2010.01.011 [doi]
AB  - Deep brain stimulation (DBS) has proven a powerful treatment for medication
      refractory movement disorders. Success in this group of patients has allowed
      preliminary studies of DBS to proceed in severe and medication resistant cases of
      depression, obsessive-compulsive disorder (OCD) and Tourette's syndrome (TS).
      Pathophysiological and imaging studies along with attempts at lesioning the basal
      ganglia, have offered clues as to nodes in the circuitry that may be amenable to 
      neuromodulation. DBS in neuropsychiatric illness has offered hope, but at this
      time rigorous screening by interdisciplinary and ethical teams should be employed
      when establishing treatment candidacy. A cautious approach to these disorders
      utilizing institutional review board approved research protocols will hopefully
      shed light onto patient selection and brain target(s) for each disorder. We need 
      to keep an open mind as we move forward and especially that rational therapy may 
      need to be patient and symptom specific. This review will summarize each disorder
      (depression, OCD and TS), review pathophysiology (both known and speculated), and
      update the current observations on DBS in each neuropsychiatric condition.
FAU - Ward, Herbert E
AU  - Ward HE
AD  - University of Florida Department of Psychiatry, McKnight Brain Institute,
      Movement Disorders Center, PO Box 100283, Gainesville, FL 32610-0383, USA.
      hward@ufl.edu <hward@ufl.edu>
FAU - Hwynn, Nelson
AU  - Hwynn N
FAU - Okun, Michael S
AU  - Okun MS
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100121
PL  - United States
TA  - Neurobiol Dis
JT  - Neurobiology of disease
JID - 9500169
SB  - IM
MH  - Deep Brain Stimulation/*methods
MH  - Humans
MH  - Mental Disorders/*therapy
RF  - 106
EDAT- 2010/01/26 06:00
MHDA- 2010/08/18 06:00
CRDT- 2010/01/26 06:00
PHST- 2009/02/11 00:00 [received]
PHST- 2009/09/16 00:00 [revised]
PHST- 2010/01/14 00:00 [accepted]
PHST- 2010/01/26 06:00 [entrez]
PHST- 2010/01/26 06:00 [pubmed]
PHST- 2010/08/18 06:00 [medline]
AID - S0969-9961(10)00013-6 [pii]
AID - 10.1016/j.nbd.2010.01.011 [doi]
PST - ppublish
SO  - Neurobiol Dis. 2010 Jun;38(3):346-53. doi: 10.1016/j.nbd.2010.01.011. Epub 2010
      Jan 21.


PMID- 20096254
OWN - NLM
STAT- MEDLINE
DCOM- 20100301
LR  - 20211020
IS  - 1097-6868 (Electronic)
IS  - 0002-9378 (Linking)
VI  - 202
IP  - 1
DP  - 2010 Jan
TI  - Injectable candidate sealants for fetal membrane repair: bonding and toxicity in 
      vitro.
PG  - 85.e1-9
LID - 10.1016/j.ajog.2009.07.051 [doi]
AB  - OBJECTIVE: This study was undertaken to test injectable surgical sealants that
      are biocompatible with fetal membranes and that are to be used eventually for the
      closure of iatrogenic membrane defects. STUDY DESIGN: Dermabond (Ethicon Inc,
      Norderstedt, Germany), Histoacryl (B. Braun GmbH, Tuttlingen, Germany), and
      Tissucol (Baxter AG, Volketwil, Switzerland) fibrin glue, and 3 types of in situ 
      forming poly(ethylene glycol)-based polymer hydrogels were tested for acute
      toxicity on direct contact with fetal membranes for 24 hours. For the
      determination of elution toxicity, extracts of sealants were incubated on amnion 
      cell cultures for 72 hours. Bonding and toxicity was assessed through morphologic
      and/or biochemical analysis. RESULTS: Extracts of all adhesives were nontoxic for
      cultured cells. However, only Tissucol and 1 type of poly(ethylene glycol)-based 
      hydrogel, which is a mussel-mimetic tissue adhesive, showed efficient,
      nondisruptive, nontoxic bonding to fetal membranes. Mussel-mimetic tissue
      adhesive that was applied over membrane defects that were created with a 3.5-mm
      trocar accomplished leak-proof closure that withstood membrane stretch in an in
      vitro model. CONCLUSION: A synthetic hydrogel-type tissue adhesive that merits
      further evaluation in vivo emerged as a potential sealing modality for iatrogenic
      membrane defects.
CI  - 2010 Mosby, Inc.
FAU - Bilic, Grozdana
AU  - Bilic G
AD  - Department of Obstetrics, University Hospital Zurich, Switzerland.
FAU - Brubaker, Carrie
AU  - Brubaker C
FAU - Messersmith, Phillip B
AU  - Messersmith PB
FAU - Mallik, Ajit S
AU  - Mallik AS
FAU - Quinn, Thomas M
AU  - Quinn TM
FAU - Haller, Claudia
AU  - Haller C
FAU - Done, Elisa
AU  - Done E
FAU - Gucciardo, Leonardo
AU  - Gucciardo L
FAU - Zeisberger, Steffen M
AU  - Zeisberger SM
FAU - Zimmermann, Roland
AU  - Zimmermann R
FAU - Deprest, Jan
AU  - Deprest J
FAU - Zisch, Andreas H
AU  - Zisch AH
LA  - eng
GR  - R01 DE014193/DE/NIDCR NIH HHS/United States
GR  - UL1 RR025741-01/RR/NCRR NIH HHS/United States
GR  - UL1 RR025741/RR/NCRR NIH HHS/United States
GR  - T90 DA022881/DA/NIDA NIH HHS/United States
GR  - DE014193/DE/NIDCR NIH HHS/United States
GR  - R37 DE014193/DE/NIDCR NIH HHS/United States
GR  - 5 T90 DA022881/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Obstet Gynecol
JT  - American journal of obstetrics and gynecology
JID - 0370476
RN  - 0 (Cyanoacrylates)
RN  - 0 (Fibrin Tissue Adhesive)
RN  - 0 (Hydrogels)
RN  - 0 (Tissue Adhesives)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 6C655P1XVG (octyl 2-cyanoacrylate)
RN  - F8CEP82QNP (Enbucrilate)
SB  - IM
MH  - Amnion/cytology/*drug effects/*surgery
MH  - Cyanoacrylates/administration & dosage/*pharmacokinetics/pharmacology
MH  - Enbucrilate/administration & dosage/pharmacology
MH  - Female
MH  - Fetal Membranes, Premature Rupture
MH  - Fetoscopy
MH  - Fibrin Tissue Adhesive/administration & dosage/*pharmacology
MH  - Humans
MH  - Hydrogels/administration & dosage/*therapeutic use
MH  - In Vitro Techniques
MH  - Materials Testing
MH  - Polyethylene Glycols/administration & dosage/*pharmacology
MH  - Pregnancy
MH  - Tissue Adhesives/administration & dosage/*pharmacology
PMC - PMC2837921
MID - NIHMS173376
EDAT- 2010/01/26 06:00
MHDA- 2010/03/02 06:00
CRDT- 2010/01/26 06:00
PHST- 2009/04/18 00:00 [received]
PHST- 2009/04/18 00:00 [revised]
PHST- 2009/07/16 00:00 [accepted]
PHST- 2010/01/26 06:00 [entrez]
PHST- 2010/01/26 06:00 [pubmed]
PHST- 2010/03/02 06:00 [medline]
AID - S0002-9378(09)00836-9 [pii]
AID - 10.1016/j.ajog.2009.07.051 [doi]
PST - ppublish
SO  - Am J Obstet Gynecol. 2010 Jan;202(1):85.e1-9. doi: 10.1016/j.ajog.2009.07.051.


PMID- 20096134
OWN - NLM
STAT- MEDLINE
DCOM- 20100924
LR  - 20211020
IS  - 1471-2342 (Electronic)
IS  - 1471-2342 (Linking)
VI  - 10
DP  - 2010 Jan 24
TI  - Agreement of left ventricular mass in steady state free precession and delayed
      enhancement MR images: implications for quantification of fibrosis in congenital 
      and ischemic heart disease.
PG  - 4
LID - 10.1186/1471-2342-10-4 [doi]
AB  - BACKGROUND: Left ventricular mass (LVM) is used when expressing infarct or
      fibrosis as a percentage of the left ventricle (LV). Quantification of LVM is
      interchangeably carried out in cine steady state free precession (SSFP) and
      delayed enhancement (DE) magnetic resonance imaging (MRI). However, these
      techniques may yield different LVM. Therefore, the aim of the study was to
      compare LVM determined by SSFP and DE MRI in patients and determine the agreement
      with these sequences with ex vivo data in an experimental animal model. METHODS: 
      Ethics committees approved human and animal studies. Informed written consent was
      obtained from all patients. SSFP and DE images were acquired in 60 patients (20
      with infarction, 20 without infarction and 20 pediatric patients). Ex vivo MRI
      was used as reference method for LVM in 19 pigs and compared to in vivo SSFP and 
      DE. RESULTS: LVM was greater in SSFP than in DE (p < 0.001) with a bias of 5.0
      +/- 6.7% in humans (r2 = 0.98), and a bias of 7.3 +/- 6.7% (p < 0.001) in pigs
      (r2 = 0.83). Bias for SSFP and DE images compared to ex vivo LVM was -0.2 +/-
      9.0% and -7.7 +/- 8.5% respectively. CONCLUSIONS: LVM was higher when measured
      with SSFP compared to DE. Thus, the percentage infarction of the LV will differ
      if SSFP or DE is used to determine LVM. There was no significant difference
      between SSFP and ex vivo LVM suggesting that SSFP is more accurate for LVM
      quantification. To avoid intrinsic error due to the differences between the
      sequences, we suggest using DE when expressing infarct as a percentage of LVM.
FAU - Stephensen, Sigurdur S
AU  - Stephensen SS
AD  - Department of Radiology and Physiology, Lund University and Lund University
      Hospital, Lund, Sweden.
FAU - Carlsson, Marcus
AU  - Carlsson M
FAU - Ugander, Martin
AU  - Ugander M
FAU - Engblom, Henrik
AU  - Engblom H
FAU - Olivecrona, Goran
AU  - Olivecrona G
FAU - Erlinge, David
AU  - Erlinge D
FAU - Arheden, Hakan
AU  - Arheden H
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100124
PL  - England
TA  - BMC Med Imaging
JT  - BMC medical imaging
JID - 100968553
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Animals
MH  - Child
MH  - Contrast Media
MH  - Female
MH  - Fibrosis/pathology
MH  - *Gadolinium DTPA
MH  - Heart Defects, Congenital/complications/*pathology
MH  - Heart Ventricles/*pathology
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/complications/*pathology
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Swine
MH  - Ventricular Dysfunction, Left/etiology/*pathology
MH  - Young Adult
PMC - PMC2881013
EDAT- 2010/01/26 06:00
MHDA- 2010/09/25 06:00
CRDT- 2010/01/26 06:00
PHST- 2009/08/18 00:00 [received]
PHST- 2010/01/24 00:00 [accepted]
PHST- 2010/01/26 06:00 [entrez]
PHST- 2010/01/26 06:00 [pubmed]
PHST- 2010/09/25 06:00 [medline]
AID - 1471-2342-10-4 [pii]
AID - 10.1186/1471-2342-10-4 [doi]
PST - epublish
SO  - BMC Med Imaging. 2010 Jan 24;10:4. doi: 10.1186/1471-2342-10-4.


PMID- 20096111
OWN - NLM
STAT- MEDLINE
DCOM- 20100504
LR  - 20220330
IS  - 1475-2875 (Electronic)
IS  - 1475-2875 (Linking)
VI  - 9
DP  - 2010 Jan 22
TI  - Treatment of asymptomatic carriers with artemether-lumefantrine: an opportunity
      to reduce the burden of malaria?
PG  - 30
LID - 10.1186/1475-2875-9-30 [doi]
AB  - BACKGROUND: Increased investment and commitment to malaria prevention and
      treatment strategies across Africa has produced impressive reductions in the
      incidence of this disease. Nevertheless, it is clear that further interventions
      will be necessary to meet the international target of a reversal in the incidence
      of malaria by 2015. This article discusses the prospective role of an innovative 
      malaria control strategy - the community-based treatment of asymptomatic carriers
      of Plasmodium falciparum, with artemisinin-based combination therapy (ACT). The
      potential of this intervention was considered by key scientists in the field at
      an Advisory Board meeting held in Basel, in April 2009. This article summarizes
      the discussions that took place among the participants. PRESENTATION OF THE
      HYPOTHESIS: Asymptomatic carriers do not seek treatment for their infection and, 
      therefore, constitute a reservoir of parasites and thus a real public-health
      risk. The systematic identification and treatment of individuals with
      asymptomatic P. falciparum as part of a surveillance intervention strategy should
      reduce the parasite reservoir, and if this pool is greatly reduced, it will
      impact disease transmission. TESTING THE HYPOTHESIS: This article considers the
      populations that could benefit from such a strategy and examines the ethical
      issues associated with the treatment of apparently healthy individuals, who
      represent a neglected public health risk. The potential for the treatment of
      asymptomatic carriers to impair the development of protective immunity, resulting
      in a 'rebound' and age escalation of malaria incidence, is also discussed.For
      policymakers to consider the treatment of asymptomatic carriers with ACT as a new
      tool in their malaria control programmes, it will be important to demonstrate
      that such a strategy can produce significant benefits, without having a negative 
      impact on the efficacy of ACT and the health of the target population.
      IMPLICATIONS OF THE HYPOTHESIS: The treatment of asymptomatic carriers with ACT
      is an innovative and essential tool for breaking the cycle of infection in some
      transmission settings. Safe and effective medicines can save the lives of
      children, but the reprieve is only temporary so long as the mosquitoes can become
      re-infected from the asymptomatic carriers. With improvements in rapid diagnostic
      tests that allow easier identification of asymptomatic carriers, the elimination 
      of the pool of parasites is within reach.
FAU - Ogutu, Bernhards
AU  - Ogutu B
AD  - Walter Reed Project/Centre for Clinical Research-Kenya Medical Research
      Institute, Nairobi, Kenya. bogutu@wrp-ksm.org
FAU - Tiono, Alfred B
AU  - Tiono AB
FAU - Makanga, Michael
AU  - Makanga M
FAU - Premji, Zulfiqarali
AU  - Premji Z
FAU - Gbadoe, Adama Dodji
AU  - Gbadoe AD
FAU - Ubben, David
AU  - Ubben D
FAU - Marrast, Anne Claire
AU  - Marrast AC
FAU - Gaye, Oumar
AU  - Gaye O
LA  - eng
PT  - Journal Article
DEP - 20100122
PL  - England
TA  - Malar J
JT  - Malaria journal
JID - 101139802
RN  - 0 (Antimalarials)
RN  - 0 (Artemether, Lumefantrine Drug Combination)
RN  - 0 (Artemisinins)
RN  - 0 (Drug Combinations)
RN  - 0 (Ethanolamines)
RN  - 0 (Fluorenes)
SB  - IM
MH  - Africa South of the Sahara/epidemiology
MH  - Antimalarials/*therapeutic use
MH  - Artemether, Lumefantrine Drug Combination
MH  - Artemisinins/*therapeutic use
MH  - Carrier State/blood/*epidemiology/parasitology
MH  - Cost of Illness
MH  - Drug Combinations
MH  - Drug Therapy, Combination
MH  - Ethanolamines/*therapeutic use
MH  - Female
MH  - Fluorenes/*therapeutic use
MH  - Humans
MH  - Incidence
MH  - Malaria, Falciparum/*drug therapy/epidemiology/prevention & control/transmission
MH  - Male
MH  - Parasitemia/drug therapy/epidemiology
MH  - Plasmodium falciparum/*drug effects/isolation & purification
MH  - Population Surveillance
MH  - Prevalence
MH  - Risk
MH  - Treatment Outcome
PMC - PMC2824802
EDAT- 2010/01/26 06:00
MHDA- 2010/05/05 06:00
CRDT- 2010/01/26 06:00
PHST- 2009/09/25 00:00 [received]
PHST- 2010/01/22 00:00 [accepted]
PHST- 2010/01/26 06:00 [entrez]
PHST- 2010/01/26 06:00 [pubmed]
PHST- 2010/05/05 06:00 [medline]
AID - 1475-2875-9-30 [pii]
AID - 10.1186/1475-2875-9-30 [doi]
PST - epublish
SO  - Malar J. 2010 Jan 22;9:30. doi: 10.1186/1475-2875-9-30.


PMID- 20094933
OWN - NLM
STAT- MEDLINE
DCOM- 20100521
LR  - 20181201
IS  - 1540-4048 (Electronic)
IS  - 0163-4372 (Linking)
VI  - 53
IP  - 2
DP  - 2010 Feb
TI  - Using multidisciplinary teams to address ethical dilemmas with older adults who
      hoard.
PG  - 137-47
LID - 10.1080/01634370903340353 [doi]
AB  - Multidisciplinary teams, representing professionals from diverse disciplines, are
      often involved in addressing difficult ethical dilemmas as they work with older
      adults who hoard (e.g., resolving conflicts between the older adult's freedom to 
      engage in hoarding behaviors versus individual or public safety). The purpose of 
      this article is threefold: (a) to explore the current use of hoarding task force 
      or team interventions to address ethical dilemmas that occur within hoarding
      cases; (b) to propose an ethical decision making framework for use by teams and
      others; and (c) to discuss practice implications for hoarding teams in
      implementing this ethical decision making framework.
FAU - Koenig, Terry L
AU  - Koenig TL
AD  - School of Social Welfare, University of Kansas, Lawrence, Kansas, USA.
      tkoenig@ku.edu
FAU - Chapin, Rosemary
AU  - Chapin R
FAU - Spano, Richard
AU  - Spano R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Gerontol Soc Work
JT  - Journal of gerontological social work
JID - 7903311
SB  - IM
MH  - Aged
MH  - Cognitive Behavioral Therapy/methods
MH  - *Ethics
MH  - Humans
MH  - Mental Disorders/*psychology/*therapy
MH  - Patient Care Team/*ethics
MH  - Social Work
EDAT- 2010/01/23 06:00
MHDA- 2010/05/22 06:00
CRDT- 2010/01/23 06:00
PHST- 2010/01/23 06:00 [entrez]
PHST- 2010/01/23 06:00 [pubmed]
PHST- 2010/05/22 06:00 [medline]
AID - 918772738 [pii]
AID - 10.1080/01634370903340353 [doi]
PST - ppublish
SO  - J Gerontol Soc Work. 2010 Feb;53(2):137-47. doi: 10.1080/01634370903340353.


PMID- 20094929
OWN - NLM
STAT- MEDLINE
DCOM- 20100324
LR  - 20100122
IS  - 1545-5815 (Electronic)
IS  - 0898-9621 (Linking)
VI  - 17
IP  - 1
DP  - 2010 Jan
TI  - Data safety monitoring boards: legal and ethical considerations for research
      accountability.
PG  - 30-50
LID - 10.1080/08989620903520313 [doi]
AB  - Those charged with assuring research accountability have little guidance as to
      how to best structure and manage data safety monitoring boards (DSMBs). One major
      concern is increased litigation surrounding human subject research which has led 
      research institutions and those asked to serve on DSMBs to seek legal counsel
      regarding their risk of liability for DSMB activities. A major challenge is
      assessing the risk of potential liability. Yet, potential liability for DSMBs and
      their members has not been adequately addressed in the literature. The purpose of
      this article is to provide a legal and accountability analysis to begin to fill
      this gap. This article undertakes an analysis and exploration of the potential
      liability that exists for DSMBs and their members under negligence theory and
      discusses the means by which DSMBs and their members may avoid litigation or
      defend themselves in the face of a lawsuit. Research accountability implications 
      of imposing liability, or not, on DSMBs are also considered. It is suggested that
      legislation be contemplated requiring sponsors to indemnify DSMBs and their
      members in the face of litigation.
FAU - Tereskerz, Patricia M
AU  - Tereskerz PM
AD  - University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA. 
      PJM7s@Virginia.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Account Res
JT  - Accountability in research
JID - 9100813
SB  - IM
MH  - Biomedical Research/*ethics/*legislation & jurisprudence
MH  - Clinical Trials Data Monitoring Committees/*ethics/*legislation &
      jurisprudence/organization & administration
MH  - Clinical Trials as Topic/ethics/legislation & jurisprudence
MH  - Humans
MH  - Liability, Legal
MH  - Malpractice
MH  - United States
MH  - United States Food and Drug Administration
EDAT- 2010/01/23 06:00
MHDA- 2010/03/25 06:00
CRDT- 2010/01/23 06:00
PHST- 2010/01/23 06:00 [entrez]
PHST- 2010/01/23 06:00 [pubmed]
PHST- 2010/03/25 06:00 [medline]
AID - 918771509 [pii]
AID - 10.1080/08989620903520313 [doi]
PST - ppublish
SO  - Account Res. 2010 Jan;17(1):30-50. doi: 10.1080/08989620903520313.


PMID- 20094928
OWN - NLM
STAT- MEDLINE
DCOM- 20100324
LR  - 20100122
IS  - 1545-5815 (Electronic)
IS  - 0898-9621 (Linking)
VI  - 17
IP  - 1
DP  - 2010 Jan
TI  - Ethical and regulatory challenges in psychophysiology and neuroscience-based
      technology for determining behavior.
PG  - 8-29
LID - 10.1080/08989620903520271 [doi]
AB  - In the past three decades, there has been an explosion in research to understand 
      the mechanisms of brain function. Recent advances in psychophysiology and
      neuroscience, while still limited, have sparked great interest in developing
      technologies that could peer into the brain and be used to identify or indicate
      certain behaviors. The polygraph (lie detector) represents an old technology used
      for discerning clues to the human brain; functional magnetic resonance imaging
      (fMRI) represents one of the newest efforts. The use of these technologies in
      intelligence and counterintelligence in the field without validation represents a
      major concern about its usefulness. Both research on this new technology and
      subsequent use on public raise ethical challenges. This article will address the 
      overall ethical issues associated with these new technologies. The report
      identifies the ethical and cultural challenges in conducting research on these
      new tools, explores the possibility of using current U.S. regulatory requirements
      regarding drugs and devices as a model for regulating these new technologies, and
      suggests approaches for the future.
FAU - Shamoo, Adil E
AU  - Shamoo AE
AD  - University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
      ashamoo@umaryland.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Account Res
JT  - Accountability in research
JID - 9100813
SB  - IM
CIN - Account Res. 2010 Jan;17(1):1-7. PMID: 20094927
MH  - *Behavior
MH  - Biomedical Research/*ethics/*legislation & jurisprudence
MH  - Electroencephalography
MH  - Government Regulation
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Neurosciences
MH  - Patient Rights
MH  - Positron-Emission Tomography
MH  - Psychophysiology
MH  - Reproducibility of Results
MH  - Social Justice
MH  - Spectroscopy, Near-Infrared
MH  - *Technology Assessment, Biomedical
MH  - Transcranial Magnetic Stimulation
EDAT- 2010/01/23 06:00
MHDA- 2010/03/25 06:00
CRDT- 2010/01/23 06:00
PHST- 2010/01/23 06:00 [entrez]
PHST- 2010/01/23 06:00 [pubmed]
PHST- 2010/03/25 06:00 [medline]
AID - 918771039 [pii]
AID - 10.1080/08989620903520271 [doi]
PST - ppublish
SO  - Account Res. 2010 Jan;17(1):8-29. doi: 10.1080/08989620903520271.


PMID- 20094921
OWN - NLM
STAT- MEDLINE
DCOM- 20120209
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 17
IP  - 2
DP  - 2011 Jun
TI  - Ethics of human enhancement: an executive summary.
PG  - 201-12
LID - 10.1007/s11948-009-9191-9 [doi]
FAU - Allhoff, Fritz
AU  - Allhoff F
AD  - Department of Philosophy, Western Michigan University, Kalamazoo, MI 49008, USA. 
      fritz.allhoff@wmich.edu
FAU - Lin, Patrick
AU  - Lin P
FAU - Steinberg, Jesse
AU  - Steinberg J
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20100122
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Biomedical Enhancement/*ethics
MH  - Humans
MH  - Morals
MH  - Personal Autonomy
EDAT- 2010/01/23 06:00
MHDA- 2012/02/10 06:00
CRDT- 2010/01/23 06:00
PHST- 2009/12/18 00:00 [received]
PHST- 2009/12/26 00:00 [accepted]
PHST- 2010/01/23 06:00 [entrez]
PHST- 2010/01/23 06:00 [pubmed]
PHST- 2012/02/10 06:00 [medline]
AID - 10.1007/s11948-009-9191-9 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2011 Jun;17(2):201-12. doi: 10.1007/s11948-009-9191-9. Epub 2010 
      Jan 22.


PMID- 20094021
OWN - NLM
STAT- MEDLINE
DCOM- 20100422
LR  - 20211020
IS  - 1545-7214 (Electronic)
IS  - 1064-7481 (Linking)
VI  - 18
IP  - 1
DP  - 2010 Jan
TI  - Seeking assent and respecting dissent in dementia research.
PG  - 77-85
LID - 10.1097/JGP.0b013e3181bd1de2 [doi]
AB  - OBJECTIVES: Obtaining assent and respecting dissent are widely adopted safeguards
      when conducting dementia research involving individuals who lack consent
      capacity, but there is no consensus on how assent and dissent should be defined
      or what procedures should be used regarding them. Our objective was to provide
      recommendations on these issues based on the opinions of knowledgeable key
      informants. DESIGN: Cross-sectional qualitative research. SETTING: University
      research institutions. PARTICIPANTS: Forty informants, including 1) nationally
      known experts on dementia and research ethics, 2) dementia researchers, and 3)
      dementia caregivers and advocates. MEASUREMENTS: Semistructured individual and
      focus group interviews, audio recorded, and transcribed for content analysis.
      RESULTS: Assent and dissent should be defined broadly and based on an assessment 
      of how adults who lack consent capacity can express or indicate their preferences
      verbally, behaviorally, or emotionally. Assent requires the ability to indicate a
      meaningful choice and at least a minimal level of understanding. Assent should be
      required whenever an individual has the ability to assent, and dissent should be 
      binding if it is unequivocal or sustained after an effort to relieve concerns
      and/or distress. Standards for seeking assent and respecting dissent should not
      be linked to the risks or potential benefits of a study. Lacking the ability to
      assent and/or dissent should not automatically preclude research participation.
      CONCLUSIONS: Obtaining assent and respecting dissent from individuals who lack
      consent capacity for dementia research allows them to participate, to the extent 
      possible, in the consent process. Assent and dissent are important independent
      ethical constructs.
FAU - Black, Betty S
AU  - Black BS
AD  - Department of Psychiatry and Behavioral Sciences, Johns Hopkins Medical
      Institutions, Baltimore, MD, USA. bblack@jhmi.edu
FAU - Rabins, Peter V
AU  - Rabins PV
FAU - Sugarman, Jeremy
AU  - Sugarman J
FAU - Karlawish, Jason H
AU  - Karlawish JH
LA  - eng
GR  - R21 AG030036/AG/NIA NIH HHS/United States
GR  - R21 AG030036-02/AG/NIA NIH HHS/United States
GR  - R21AG30036/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Am J Geriatr Psychiatry
JT  - The American journal of geriatric psychiatry : official journal of the American
      Association for Geriatric Psychiatry
JID - 9309609
SB  - IM
MH  - Adult
MH  - Dementia/*psychology
MH  - *Dissent and Disputes
MH  - Female
MH  - Humans
MH  - Informed Consent/*standards
MH  - Male
MH  - Mental Competency/*standards
MH  - Patient Selection/ethics
MH  - Research Subjects/*psychology
PMC - PMC2811536
MID - NIHMS153830
EDAT- 2010/01/23 06:00
MHDA- 2010/04/23 06:00
CRDT- 2010/01/23 06:00
PHST- 2010/01/23 06:00 [entrez]
PHST- 2010/01/23 06:00 [pubmed]
PHST- 2010/04/23 06:00 [medline]
AID - 10.1097/JGP.0b013e3181bd1de2 [doi]
AID - S1064-7481(12)60275-9 [pii]
PST - ppublish
SO  - Am J Geriatr Psychiatry. 2010 Jan;18(1):77-85. doi: 10.1097/JGP.0b013e3181bd1de2.


PMID- 20093514
OWN - NLM
STAT- MEDLINE
DCOM- 20100225
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 254
IP  - 2
DP  - 2010 Feb
TI  - Noninvasive contrast-enhanced US quantitative assessment of tumor
      microcirculation in a murine model: effect of discontinuing anti-VEGF therapy.
PG  - 420-9
LID - 10.1148/radiol.09090728 [doi]
AB  - PURPOSE: To determine, by using contrast material-enhanced ultrasonography (US), 
      how quickly renal tumors grafted in mice begin to revascularize after stopping
      bevacizumab treatment. MATERIALS AND METHODS: All experiments were approved by
      the regional ethics committee. A human tumor cell line SK-NEP-1 was grafted at
      day 0 in the left kidney of 50 nude mice. Forty-two mice developed tumors and
      longitudinal follow-up was performed on 32 surviving mice. From day 13, 14
      controls received biweekly saline; 11 mice received biweekly bevacizumab until
      day 35 (continuous); and seven received biweekly bevacizumab until day 22, then
      biweekly placebo until day 35 (discontinued). Contrast-enhanced US was performed 
      on days 13, 14, 22, 27, and 35. Once the injected contrast material distribution 
      reached an equilibrium phase, high-acoustic pressure pulses were applied to
      destroy microbubbles in the capillary bed in the imaged plane. Reperfusion was
      monitored, and time-signal intensity (SI) curves were obtained from the linear
      average of SIs in intratumoral and matched-depth renal cortex regions of
      interest. A kinetic parameter calculated from reperfusion curves reflects local
      perfusion, normalized with respect to adjacent renal cortex perfusion. Normalized
      perfusion obtained from each group was compared with that from the other groups
      and with necrosis percentages and microvascular density assessed histologically
      at day 35. Comparisons were made by using analyses of variance and Tukey-Kramer
      tests. RESULTS: The lowest excised mean tumor weights (+/- standard deviation)
      corresponded to the longest bevacizumab-treatment duration: 1.4 g +/- 1.1
      (continuous-treatment) compared with 2.3 g +/- 2.1 (discontinued) and 3.7 g +/-
      1.9 (control) (P = .01). On day 35, the respective control and continuously
      treated groups had comparable and significantly larger necrotic areas: 37% +/- 14
      and 32% +/- 17 larger than the discontinued-treatment group (15% +/- 9; P < .05).
      Normalized perfusion increased significantly with time (P = .02) in the
      discontinued-treatment group after therapy ceased (day 22). CONCLUSION:
      Noninvasively measured contrast-enhanced US parameters demonstrated tumor
      revascularization after stopping antiangiogenic therapy in this murine tumor
      model.
CI  - (c) RSNA, 2010.
FAU - Guibal, Aymeric
AU  - Guibal A
AD  - Department of Radiology, GH Pitie-Salpetriere, Assistance Publique-Hopitaux de
      Paris, France.
FAU - Taillade, Laurent
AU  - Taillade L
FAU - Mule, Sebastien
AU  - Mule S
FAU - Comperat, Eva
AU  - Comperat E
FAU - Badachi, Yasmina
AU  - Badachi Y
FAU - Golmard, Jean Louis
AU  - Golmard JL
FAU - Le Guillou-Buffello, Delphine
AU  - Le Guillou-Buffello D
FAU - Rixe, Olivier
AU  - Rixe O
FAU - Bridal, S Lori
AU  - Bridal SL
FAU - Lucidarme, Olivier
AU  - Lucidarme O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Angiogenesis Inhibitors)
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antibodies, Monoclonal, Humanized)
RN  - 0 (Contrast Media)
RN  - 0 (Phospholipids)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (contrast agent BR1)
RN  - 2S9ZZM9Q9V (Bevacizumab)
RN  - WS7LR3I1D6 (Sulfur Hexafluoride)
SB  - IM
CIN - Radiology. 2010 Feb;254(2):317-8. PMID: 20093504
MH  - Analysis of Variance
MH  - Angiogenesis Inhibitors/administration & dosage/*pharmacology
MH  - Animals
MH  - Antibodies, Monoclonal/administration & dosage/*pharmacology
MH  - Antibodies, Monoclonal, Humanized
MH  - Bevacizumab
MH  - Cell Line, Tumor
MH  - Contrast Media
MH  - Female
MH  - Humans
MH  - Mice
MH  - Mice, Nude
MH  - Microcirculation
MH  - Neoplasms, Experimental/*diagnostic imaging/*drug therapy
MH  - Neovascularization, Pathologic/*diagnostic imaging/*drug therapy
MH  - Phospholipids
MH  - Sulfur Hexafluoride
MH  - Ultrasonography
MH  - Vascular Endothelial Growth Factor A/*antagonists & inhibitors
EDAT- 2010/01/23 06:00
MHDA- 2010/02/26 06:00
CRDT- 2010/01/23 06:00
PHST- 2010/01/23 06:00 [entrez]
PHST- 2010/01/23 06:00 [pubmed]
PHST- 2010/02/26 06:00 [medline]
AID - 254/2/420 [pii]
AID - 10.1148/radiol.09090728 [doi]
PST - ppublish
SO  - Radiology. 2010 Feb;254(2):420-9. doi: 10.1148/radiol.09090728.


PMID- 20093511
OWN - NLM
STAT- MEDLINE
DCOM- 20100225
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 254
IP  - 2
DP  - 2010 Feb
TI  - Presence of coronary plaques in patients with nonalcoholic fatty liver disease.
PG  - 393-400
LID - 10.1148/radiol.09090769 [doi]
AB  - PURPOSE: To evaluate the relationship between nonalcoholic fatty liver disease
      (NAFLD) and coronary artery disease (CAD) and to define determinants of CAD in
      patients with or without metabolic syndrome. MATERIALS AND METHODS: This study
      was approved by the local ethics committee; informed consent was obtained.
      Twenty-nine subjects (mean age, 53 years +/- 7 [standard deviation]) with low to 
      intermediate risk for CAD and with fatty liver were included. Thirty-two sex- and
      age-matched individuals without NAFLD served as controls. CAD was defined as a
      stenosis of more than 50% in at least one major coronary artery. Fatty liver was 
      assessed by means of an attenuation of -10 HU or higher (calculated as liver
      attenuation minus spleen attenuation) by using computed tomography (CT), coronary
      plaques and stenosis by using CT coronary angiography, and biomarkers of insulin 
      resistance, lipotoxicity, systemic inflammation, and oxidant and antioxidant
      status. A logistic regression analysis was performed to study multivariable
      associations. RESULTS: When compared with controls, NAFLD patients showed a
      higher prevalence of calcified and noncalcified coronary plaques (67% vs 34% and 
      52% vs 29%, respectively; both P < .001), higher prevalence of nonobstructive
      coronary stenosis (34% vs 14%; P < .008), higher homeostasis model assessment of 
      insulin resistance (3.8 epsilonU/mL +/- 3.6 vs 2.6 epsilonU/mL +/- 3.2; P < .005)
      and higher triglyceride levels (208 mg/dL +/- 87 vs 148 mg/dL +/- 70; P < .005). 
      Fatty liver proved to be a strong predictor of coronary atherosclerosis (odds
      ratio [OR], 2; P < .04), independent of indicators for metabolic syndrome (OR,
      1.2; P > .2) and C-reactive protein levels (OR, 0.7; P > .4). CONCLUSION:
      Patients with NAFLD, even without metabolic syndrome, are at high risk for
      atherosclerosis. Assessment of NAFLD may be helpful for cardiovascular risk
      stratification.
CI  - (c) RSNA, 2010.
FAU - Assy, Nimer
AU  - Assy N
AD  - Liver Unit, Ziv Medical Centre, Box 1008, Safed 13100, Israel.
      assy.n@ziv.health.gov.il
FAU - Djibre, Agness
AU  - Djibre A
FAU - Farah, Raymond
AU  - Farah R
FAU - Grosovski, Maria
AU  - Grosovski M
FAU - Marmor, Alon
AU  - Marmor A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Biomarkers)
RN  - 0 (Contrast Media)
RN  - 17E17JBP8L (iomeprol)
RN  - JR13W81H44 (Iopamidol)
SB  - IM
MH  - Biomarkers/analysis
MH  - Case-Control Studies
MH  - Contrast Media
MH  - Coronary Angiography/*methods
MH  - Coronary Artery Disease/*complications/*diagnostic imaging
MH  - Fatty Liver/*complications/*diagnostic imaging
MH  - Female
MH  - Humans
MH  - Iopamidol/analogs & derivatives
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Prospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2010/01/23 06:00
MHDA- 2010/02/26 06:00
CRDT- 2010/01/23 06:00
PHST- 2010/01/23 06:00 [entrez]
PHST- 2010/01/23 06:00 [pubmed]
PHST- 2010/02/26 06:00 [medline]
AID - 254/2/393 [pii]
AID - 10.1148/radiol.09090769 [doi]
PST - ppublish
SO  - Radiology. 2010 Feb;254(2):393-400. doi: 10.1148/radiol.09090769.


PMID- 20093320
OWN - NLM
STAT- MEDLINE
DCOM- 20110511
LR  - 20110203
IS  - 1461-7285 (Electronic)
IS  - 0269-8811 (Linking)
VI  - 25
IP  - 2
DP  - 2011 Feb
TI  - Ethical issues in consenting vulnerable patients for neuroscience research.
PG  - 205-10
LID - 10.1177/0269881109349838 [doi]
AB  - Many subjects cannot give fully informed consent to take part in research by
      virtue of age or mental capacity. However, it is unacceptable to deny these
      patients involvement in research by virtue of a lack of capacity to consent to
      such research. Further, this would hinder the advancement of medical science and 
      technologies that might ultimately benefit these patients. Conversely, it is as
      unacceptable to discriminate against these patients and their condition as it is 
      to exploit them or expose them to undue risk. Neuroscientific research raises a
      number of specific ethical issues in this patient population, in particular
      issues of consent, potential benefits of research, management of incidental
      findings and the assignment of appropriate controls. This paper examines the
      dilemmas that surround such ethical issues, and demonstrates that various
      procedures including informed consent, deferred consent and consent by proxy can 
      be used to consent patients in both the standard medical and research arenas.
      Researchers, clinicians and regulatory authorities must work together to
      understand the benefits, limitations, risks and obligations of any research study
      involving these patients in order to advance medical care.
FAU - Labuzetta, Jamie N
AU  - Labuzetta JN
AD  - Department of Clinical Neurosciences, University of Cambridge, Addenbrookes
      Hospital, Cambridge, UK.
FAU - Burnstein, Rowan
AU  - Burnstein R
FAU - Pickard, John
AU  - Pickard J
LA  - eng
GR  - Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100121
PL  - United States
TA  - J Psychopharmacol
JT  - Journal of psychopharmacology (Oxford, England)
JID - 8907828
SB  - IM
MH  - *Bioethical Issues
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Informed Consent/*ethics/standards
MH  - Mental Competency/psychology
MH  - Neurosciences/*ethics
MH  - Practice Guidelines as Topic/standards
MH  - Research Subjects/*psychology
MH  - Risk Assessment/ethics/methods
EDAT- 2010/01/23 06:00
MHDA- 2011/05/12 06:00
CRDT- 2010/01/23 06:00
PHST- 2010/01/23 06:00 [entrez]
PHST- 2010/01/23 06:00 [pubmed]
PHST- 2011/05/12 06:00 [medline]
AID - 0269881109349838 [pii]
AID - 10.1177/0269881109349838 [doi]
PST - ppublish
SO  - J Psychopharmacol. 2011 Feb;25(2):205-10. doi: 10.1177/0269881109349838. Epub
      2010 Jan 21.


PMID- 20092880
OWN - NLM
STAT- MEDLINE
DCOM- 20100330
LR  - 20100319
IS  - 1095-6859 (Electronic)
IS  - 0090-8258 (Linking)
VI  - 117
IP  - 1
DP  - 2010 Apr
TI  - The accuracy of magnetic resonance imaging in staging of vulvar cancer: a
      retrospective multi-centre study.
PG  - 82-7
LID - 10.1016/j.ygyno.2009.12.017 [doi]
AB  - OBJECTIVE: To retrospectively evaluate the diagnostic accuracy and clinical
      relevance of magnetic resonance imaging (MRI) in the management of primary and
      recurrent vulvar cancer and to examine the added value of contrast-enhanced MRI
      (CE-MRI). METHODS: The research ethics committee waived informed consent for this
      study of 49 patients with vulvar cancer (36 primary and 13 recurrent) who
      underwent MRI before surgery at three major cancer centers from December 2003 to 
      January 2008. CE-MRI was available for 31 patients (20 primary and 11 recurrent).
      MR images were retrospectively evaluated by three radiologists for tumor size and
      stage. Lymph nodes with a short axis >5 mm were measured and scored for contour, 
      presence of necrosis, loss of fatty hilum, signal intensity relative to the
      vulvar lesion, and reader's diagnosis of lymph node metastasis. Scoring was
      repeated for CE-MRI. Histopathology constituted the reference standard. RESULTS: 
      The size of the vulvar lesion was accurately characterized on MRI in 83% of
      patients. Accuracy in staging of primary vulvar cancers on unenhanced MRI was
      69.4% (n=36). Adding CE-MRI increased lesion detection and raised staging
      accuracy from 75% to 85% (n=20). For groin lymph node metastasis prediction, the 
      ratio of the short- to the long-axis diameter and the reader's diagnosis of lymph
      node metastasis yielded accuracy of 85% and 87%, respectively, in groin-by-groin 
      analysis. CONCLUSION: MRI can be useful in accurately assessing the size of
      vulvar lesion and groin lymph node metastasis. CE-MRI may be of help in improving
      local staging.
CI  - Copyright 2009 Elsevier Inc. All rights reserved.
FAU - Kataoka, Masako Yano
AU  - Kataoka MY
AD  - Department of Radiology, University of Cambridge, Addenbrooke's Hospital,
      Cambridge, UK. mk435@cam.ac.uk
FAU - Sala, Evis
AU  - Sala E
FAU - Baldwin, Peter
AU  - Baldwin P
FAU - Reinhold, Caroline
AU  - Reinhold C
FAU - Farhadi, Alex
AU  - Farhadi A
FAU - Hudolin, Turtko
AU  - Hudolin T
FAU - Hricak, Hedvig
AU  - Hricak H
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20100121
PL  - United States
TA  - Gynecol Oncol
JT  - Gynecologic oncology
JID - 0365304
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - Lymphatic Metastasis
MH  - Magnetic Resonance Imaging/*methods
MH  - Middle Aged
MH  - Neoplasm Invasiveness
MH  - Neoplasm Staging
MH  - Retrospective Studies
MH  - Vulvar Neoplasms/*diagnosis/*pathology/surgery
EDAT- 2010/01/23 06:00
MHDA- 2010/03/31 06:00
CRDT- 2010/01/23 06:00
PHST- 2009/09/15 00:00 [received]
PHST- 2009/12/09 00:00 [revised]
PHST- 2009/12/10 00:00 [accepted]
PHST- 2010/01/23 06:00 [entrez]
PHST- 2010/01/23 06:00 [pubmed]
PHST- 2010/03/31 06:00 [medline]
AID - S0090-8258(09)01018-X [pii]
AID - 10.1016/j.ygyno.2009.12.017 [doi]
PST - ppublish
SO  - Gynecol Oncol. 2010 Apr;117(1):82-7. doi: 10.1016/j.ygyno.2009.12.017. Epub 2010 
      Jan 21.


PMID- 20092587
OWN - NLM
STAT- MEDLINE
DCOM- 20100304
LR  - 20100122
IS  - 1399-0004 (Electronic)
IS  - 0009-9163 (Linking)
VI  - 77
IP  - 1
DP  - 2010 Jan
TI  - Reproductive decision-making in the context of mitochondrial DNA disorders: views
      and experiences of professionals.
PG  - 10-7
LID - 10.1111/j.1399-0004.2009.01312.x [doi]
AB  - Although a scientific and ethical debate about the possible reproductive options 
      for carriers of mitochondrial DNA (mtDNA) mutations is developing, not much
      information regarding the views and experiences of professionals exists. This
      paper explores the attitudes and experiences of professionals involved on a daily
      basis with their patients' reproductive decision-making in the context of mtDNA
      disease. Qualitative international multicenter design using in-depth
      semi-structured interviews with 20 professionals has been utilized. We identified
      four main themes emerging from the interviews. Firstly, we illustrate the
      discussion among professionals as to what extent mitochondrial genetics differs
      from other areas in genetics, both technically and ethically. Secondly, we show
      the discomfort and doubts of professionals when an mtDNA mutation is involved,
      because of the uncertainty remaining after testing. Thirdly, we discuss how
      professionals struggle with the tension between, on the one hand, the ideal of
      reproductive autonomy and, on the other hand, the reality of their professional
      responsibility and complex clinical decision-making. Fourthly, we delineate the
      strategies used by professionals in order to make attempts to control
      uncertainty. This paper illustrates the impact on professionals of reproductive
      decision-making in the context of mtDNA disease. It shows their feelings of
      discomfort when interpreting and explaining uncertain or ambiguous data and may
      be perceived as an example of how professionals deal with the inherent
      limitations in genetic knowledge representing the state of the art. Insight into 
      the experiences of professionals may contribute to a further improvement of
      reproductive genetic counseling in the context of mtDNA disorders.
FAU - Bredenoord, A L
AU  - Bredenoord AL
AD  - Maastricht University, Faculty of Health, Medicine and Life Sciences, Health,
      Ethics & Society, Research Institutes GROW and CAPHRI, Maastricht, the
      Netherlands. A.L.Bredenoord@umcutrecht.nl
FAU - Krumeich, A
AU  - Krumeich A
FAU - De Vries, M C
AU  - De Vries MC
FAU - Dondorp, W
AU  - Dondorp W
FAU - De Wert, G
AU  - De Wert G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Clin Genet
JT  - Clinical genetics
JID - 0253664
RN  - 0 (DNA, Mitochondrial)
SB  - IM
MH  - DNA, Mitochondrial/genetics
MH  - Decision Making
MH  - Family Planning Services/*ethics
MH  - *Genetic Counseling
MH  - *Health Knowledge, Attitudes, Practice
MH  - *Heterozygote
MH  - Humans
MH  - Mitochondrial Diseases/*genetics
EDAT- 2010/01/23 06:00
MHDA- 2010/03/05 06:00
CRDT- 2010/01/23 06:00
PHST- 2010/01/23 06:00 [entrez]
PHST- 2010/01/23 06:00 [pubmed]
PHST- 2010/03/05 06:00 [medline]
AID - CGE1312 [pii]
AID - 10.1111/j.1399-0004.2009.01312.x [doi]
PST - ppublish
SO  - Clin Genet. 2010 Jan;77(1):10-7. doi: 10.1111/j.1399-0004.2009.01312.x.


PMID- 20092368
OWN - NLM
STAT- MEDLINE
DCOM- 20100323
LR  - 20151119
IS  - 1600-0455 (Electronic)
IS  - 0284-1851 (Linking)
VI  - 51
IP  - 2
DP  - 2010 Mar
TI  - The hook sign for differential diagnosis of malignant from benign lesions in
      magnetic resonance mammography: experience in a study of 1084 histologically
      verified cases.
PG  - 137-43
LID - 10.3109/02841850903463638 [doi]
AB  - BACKGROUND: The hook sign (HS) has recently been introduced as a new descriptor
      for differential diagnosis in magnetic resonance mammography (MRM). PURPOSE: To
      analyze the diagnostic value of HS in a large collection of 1084 cases. MATERIAL 
      AND METHODS: This study was approved by the local ethics committee, and 1084
      consecutive lesions (no manipulations of the breast up to 12 months before MRM)
      with histological verification after MRM were included. HS was analyzed according
      to standard study protocols and was rated positive if a hook-like spiculated
      dendrite connecting a lesion with the pectoral muscle could be visualized.
      Examinations were rated by experienced observers (>500 examinations). Prevalence 
      of HS was correlated with histological diagnosis, grading, and size (chi-square
      test). Diagnostic accuracy was assessed using sensitivity, specificity, positive 
      likelihood ratio (LR+), and diagnostic odds ratio (DOR). RESULTS: HS was
      significantly associated with malignancy (P < 0.001), providing high specificity,
      LR+, and DOR (96.8%, 9.1, and 12.5, respectively). Malignant lesions >20 mm
      presented with HS significantly more often than those <20 mm (P < 0.001). HS was 
      characteristic of invasive cancers and rare in preinvasive malignomas (P <
      0.001). Prevalence of HS did not differ between invasive lobular and ductal
      carcinomas (n.s.). There was no correlation between HS and the grading of
      invasive carcinomas. CONCLUSION: In 1084 lesions, the hook sign was a specific
      descriptor for differentiation of benign and malignant lesions in MRM, with high 
      evidence for prediction of malignancy, particularly in the case of advanced
      lesions and invasive carcinomas.
FAU - Dietzel, Matthias
AU  - Dietzel M
AD  - Institute of Diagnostic and Interventional Radiology,
      Friedrich-Schiller-University Jena, Jena, Germany.
      matthias.dietzel@med.uni-jena.de
FAU - Baltzer, Pascal A T
AU  - Baltzer PA
FAU - Vag, Tibor
AU  - Vag T
FAU - Gajda, Mieczyslaw
AU  - Gajda M
FAU - Camara, Oumar
AU  - Camara O
FAU - Kaiser, Werner A
AU  - Kaiser WA
LA  - eng
PT  - Journal Article
PL  - England
TA  - Acta Radiol
JT  - Acta radiologica (Stockholm, Sweden : 1987)
JID - 8706123
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Breast Neoplasms/*pathology
MH  - Chi-Square Distribution
MH  - Contrast Media
MH  - Diagnosis, Differential
MH  - Female
MH  - Gadolinium DTPA
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Magnetic Resonance Imaging/*methods
MH  - Middle Aged
MH  - Sensitivity and Specificity
EDAT- 2010/01/23 06:00
MHDA- 2010/03/24 06:00
CRDT- 2010/01/23 06:00
PHST- 2010/01/23 06:00 [entrez]
PHST- 2010/01/23 06:00 [pubmed]
PHST- 2010/03/24 06:00 [medline]
AID - 10.3109/02841850903463638 [doi]
PST - ppublish
SO  - Acta Radiol. 2010 Mar;51(2):137-43. doi: 10.3109/02841850903463638.


PMID- 20091476
OWN - NLM
STAT- MEDLINE
DCOM- 20100402
LR  - 20100121
IS  - 1439-1074 (Electronic)
IS  - 0939-2661 (Linking)
VI  - 45
IP  - 1
DP  - 2010 Jan
TI  - [Pain management after ambulatory surgery in Germany].
PG  - 44-55
LID - 10.1055/s-0029-1243378 [doi]
AB  - An increasing percentage of surgical procedures are performed in an ambulatory
      setting. However, a fairly high number of patients experience moderate to severe 
      postoperative pain and pain is a common reason for unanticipated hospital
      admission. An adequate postoperative pain therapy in the ambulatory setting is
      therefore essential not only for ethical reasons or improvements in recovery but 
      also for economic reasons but - in Germany - still remains inadequate. The
      following article deals with the problems that cause inadequat pain therapy after
      ambulatory surgery in Germany and introduces different therapeutic options,
      strategies and drugs relevant to optimize pain therapy after ambulatory surgery. 
      Major aspects are education of the patient, the use of adequate non-opioid
      analgesics and implementation of regional analgesia techniques. Non-opioid
      analgesics are known to be effective to reduce opioid requirements and side
      effects; however, not all non-opioid analgesics are similar effective.
      Furthermore side effects and risks of these drugs need to be considered in
      individual patients. Benefits from regional anesthesia and analgesia techniques
      are well known after sugery. Experiences from other countries demonstrate
      improved analgesia, less side effects (e.g. sedation, insomnia) and increased
      patients satisfaction associated with continuous peripheral nerve blocks at home.
      In Germany, these techniques are not frequently used but need to be considered in
      the future to optimize postoperative pain management after ambulatory surgery.
CI  - (c) Georg Thieme Verlag Stuttgart New York.
FAU - Englbrecht, Jan S
AU  - Englbrecht JS
AD  - Poliklinik fur Anasthesiologie und operative Intensivmedizin am
      Universitatsklinikum Munster. Jan.Englbrecht@ukmuenster.de
FAU - Pogatzki-Zahn, Esther M
AU  - Pogatzki-Zahn EM
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Ambulante Schmerztherapie - Optimierung der Schmerztherapie nach ambulanten
      Operationen.
DEP - 20100120
PL  - Germany
TA  - Anasthesiol Intensivmed Notfallmed Schmerzther
JT  - Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS
JID - 9109478
RN  - 0 (Analgesics, Non-Narcotic)
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Anesthetics, Local)
RN  - 0 (GABA Agents)
SB  - IM
MH  - Ambulatory Care
MH  - *Ambulatory Surgical Procedures
MH  - Analgesics, Non-Narcotic/therapeutic use
MH  - Analgesics, Opioid/therapeutic use
MH  - Anesthesia, Conduction
MH  - Anesthetics, Local/therapeutic use
MH  - Drug Therapy, Combination
MH  - GABA Agents/therapeutic use
MH  - Germany
MH  - Humans
MH  - Pain, Postoperative/*therapy
RF  - 0
EDAT- 2010/01/22 06:00
MHDA- 2010/04/03 06:00
CRDT- 2010/01/22 06:00
PHST- 2010/01/22 06:00 [entrez]
PHST- 2010/01/22 06:00 [pubmed]
PHST- 2010/04/03 06:00 [medline]
AID - 10.1055/s-0029-1243378 [doi]
PST - ppublish
SO  - Anasthesiol Intensivmed Notfallmed Schmerzther. 2010 Jan;45(1):44-55. doi:
      10.1055/s-0029-1243378. Epub 2010 Jan 20.


PMID- 20091142
OWN - NLM
STAT- MEDLINE
DCOM- 20100611
LR  - 20211020
IS  - 2629-3277 (Electronic)
IS  - 2629-3277 (Linking)
VI  - 6
IP  - 1
DP  - 2010 Mar
TI  - Promising new sources for pluripotent stem cells.
PG  - 15-26
LID - 10.1007/s12015-009-9102-0 [doi]
AB  - Recent findings have placed stem cell research at the forefront of biomedical
      sciences. Basic research on embryonic stem cells (ESCs) has contributed to our
      knowledge about the developmental potential and plasticity of stem cells.
      Furthermore, it has raised hope to use these cells as potential source for
      regenerative medicine and tissue replacement after injury or disease.
      Unfortunately, ESCs can also form tumors and they are ethically controversial
      because they originate from human embryos. This review summarizes findings and
      therapeutic applications of ESCs and their alternatives: adult stem cells and iPS
      cells.
FAU - Leeb, Christian
AU  - Leeb C
AD  - Ludwig Boltzmann Institute for Cancer Research, Wahringerstrasse 13A, Vienna,
      Austria.
FAU - Jurga, Marcin
AU  - Jurga M
FAU - McGuckin, Colin
AU  - McGuckin C
FAU - Moriggl, Richard
AU  - Moriggl R
FAU - Kenner, Lukas
AU  - Kenner L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Stem Cell Rev Rep
JT  - Stem cell reviews and reports
JID - 101752767
SB  - IM
MH  - Adult Stem Cells/*physiology/transplantation
MH  - Cord Blood Stem Cell Transplantation
MH  - *Embryo Research
MH  - Fetal Blood/*cytology
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*physiology/transplantation
MH  - Pluripotent Stem Cells/*physiology/transplantation
MH  - *Regenerative Medicine
MH  - Risk Assessment
MH  - *Stem Cell Transplantation/adverse effects
RF  - 142
EDAT- 2010/01/22 06:00
MHDA- 2010/06/12 06:00
CRDT- 2010/01/22 06:00
PHST- 2010/01/22 06:00 [entrez]
PHST- 2010/01/22 06:00 [pubmed]
PHST- 2010/06/12 06:00 [medline]
AID - 10.1007/s12015-009-9102-0 [doi]
PST - ppublish
SO  - Stem Cell Rev Rep. 2010 Mar;6(1):15-26. doi: 10.1007/s12015-009-9102-0.


PMID- 20090695
OWN - NLM
STAT- MEDLINE
DCOM- 20100401
LR  - 20100121
IS  - 0093-7355 (Print)
IS  - 0093-7355 (Linking)
VI  - 39
IP  - 2
DP  - 2010 Feb
TI  - The use of performance standards by AAALAC International to evaluate ethical
      review in European institutions.
PG  - 49-53
LID - 10.1038/laban0210-49 [doi]
AB  - During the past several decades, society has become increasingly concerned about 
      the welfare of animals used in research. Today, the public asks scientists to
      justify the use of research animals and to be accountable for their welfare.
      Research institutions, government bodies and other regulatory authorities have
      developed mechanisms to ensure that researchers follow the principles of the 3Rs 
      and use and care for research animals in an ethical manner. Additionally,
      organizations such as the Association for Assessment and Accreditation of
      Laboratory Animal Care International (AAALAC International) have developed
      voluntary programs that can help researchers to ensure that they are caring for
      research animals appropriately. The author discusses how AAALAC International
      uses performance standards to evaluate the ethical review processes of European
      institutions.
FAU - Guillen, Javier
AU  - Guillen J
AD  - AAALAC International, Pamplona, Spain. jguillen@aaalac.org
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Lab Anim (NY)
JT  - Lab animal
JID - 0417737
SB  - IM
MH  - Animal Care Committees/*legislation & jurisprudence
MH  - Animal Welfare/*standards
MH  - Animals
MH  - Education, Veterinary/methods/standards
MH  - Europe
MH  - International Cooperation
MH  - Laboratory Animal Science/education/*standards
MH  - *Societies, Scientific
MH  - *Task Performance and Analysis
EDAT- 2010/01/22 06:00
MHDA- 2010/04/02 06:00
CRDT- 2010/01/22 06:00
PHST- 2009/07/09 00:00 [received]
PHST- 2009/09/30 00:00 [accepted]
PHST- 2010/01/22 06:00 [entrez]
PHST- 2010/01/22 06:00 [pubmed]
PHST- 2010/04/02 06:00 [medline]
AID - laban0210-49 [pii]
AID - 10.1038/laban0210-49 [doi]
PST - ppublish
SO  - Lab Anim (NY). 2010 Feb;39(2):49-53. doi: 10.1038/laban0210-49.


PMID- 20090675
OWN - NLM
STAT- MEDLINE
DCOM- 20100310
LR  - 20211020
IS  - 1532-6535 (Electronic)
IS  - 0009-9236 (Linking)
VI  - 87
IP  - 3
DP  - 2010 Mar
TI  - Payment to healthy volunteers in clinical research: the research subject's
      perspective.
PG  - 286-93
LID - 10.1038/clpt.2009.222 [doi]
AB  - Although there is much discussion regarding the ethics of making payments to
      healthy volunteers for participating in clinical research, little data are
      available from the point of view of the volunteers as to what they would consider
      to be fair payment. The objectives of this study were to determine healthy
      volunteers' estimates of appropriate payments for participation in hypothetical
      clinical trials in order to explore the reasoning behind these estimates and to
      examine the association between volunteer demographics and payment expectations. 
      Sixty participants with previous experience as healthy volunteers in research
      studies were presented with four hypothetical studies and interviewed about their
      impressions of burden and risks involved in the studies. They were also asked to 
      estimate an appropriate payment to the volunteers for each of the studies. For
      each of the studies, the payment estimates made by the participants varied over a
      wide range. However, each individual tended to be consistent in estimate
      placement within this range. No demographic factor was significantly associated
      with the estimated study payment. Subjects frequently mentioned risk and
      logistical burden as factors that should determine payment levels. Healthy
      volunteer subjects appear to have individualized yet consistent methods of
      arriving at estimates of payments for participating in clinical studies. These
      estimates are based on each subject's perception of study burden and associated
      risk.
FAU - Czarny, M J
AU  - Czarny MJ
AD  - School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
FAU - Kass, N E
AU  - Kass NE
FAU - Flexner, C
AU  - Flexner C
FAU - Carson, K A
AU  - Carson KA
FAU - Myers, R K
AU  - Myers RK
FAU - Fuchs, E J
AU  - Fuchs EJ
LA  - eng
GR  - UL1 RR025005/RR/NCRR NIH HHS/United States
GR  - UL1 RR025005-01/RR/NCRR NIH HHS/United States
GR  - UL1 RR025005-03/RR/NCRR NIH HHS/United States
GR  - UL1 RR 025005/RR/NCRR NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100120
PL  - United States
TA  - Clin Pharmacol Ther
JT  - Clinical pharmacology and therapeutics
JID - 0372741
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biomedical Research/*economics/methods
MH  - Clinical Trials as Topic/economics/methods
MH  - Data Collection/methods
MH  - Female
MH  - *Healthy Volunteers/legislation & jurisprudence
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Patient Selection
MH  - Research Subjects/*economics/psychology
MH  - Young Adult
PMC - PMC2946170
MID - NIHMS146991
EDAT- 2010/01/22 06:00
MHDA- 2010/03/11 06:00
CRDT- 2010/01/22 06:00
PHST- 2010/01/22 06:00 [entrez]
PHST- 2010/01/22 06:00 [pubmed]
PHST- 2010/03/11 06:00 [medline]
AID - clpt2009222 [pii]
AID - 10.1038/clpt.2009.222 [doi]
PST - ppublish
SO  - Clin Pharmacol Ther. 2010 Mar;87(3):286-93. doi: 10.1038/clpt.2009.222. Epub 2010
      Jan 20.


PMID- 20090541
OWN - NLM
STAT- MEDLINE
DCOM- 20101103
LR  - 20220331
IS  - 1365-2346 (Electronic)
IS  - 0265-0215 (Linking)
VI  - 27
IP  - 4
DP  - 2010 Apr
TI  - Effectiveness of premedication agents administered prior to nitrous oxide/oxygen.
PG  - 341-6
LID - 10.1097/EJA.0b013e3283313cdd [doi]
AB  - BACKGROUND AND OBJECTIVE: In paediatric dentistry, when anxiety, fear of dental
      procedures or behavioural impairment precludes the conduct of dental treatments, 
      sedation procedures are required. However, sedation at the desired level might
      not be achieved despite administration of various agents. The present study aimed
      to evaluate the effectiveness of oral premedication with different agents on
      children scheduled for dental treatment under nitrous oxide/oxygen (N2O/O2)
      sedation. METHODS: The present research was approved by the Ethics Committee of
      Gazi University Faculty of Medicine. Sixty children aged between 5 and 8 years,
      ASA I or II, having no mental or motor retardation, requiring at least two-visit 
      dental treatment, having no sedation or general anaesthesia experience, and
      incompliant with dental treatment (Frankl Behaviour Scale>or=3), were enrolled
      into the study after obtaining informed parental consent. The children were then 
      randomly assigned to one of four groups. The treatment regimen according to the
      study groups was as follows: oral administration of 1 mg kg(-1) hydroxyzine
      hydrochloride suspension (Atarax) 1 h preoperatively (group I, n=15), oral
      administration of 0.7 mg kg(-1) midazolam (Dormicum) 15 min preoperatively (group
      II, n=15), oral administration of 3 mg kg(-1) ketamine (Ketalar) with 0.25 mg
      kg(-1) midazolam (Dormicum) 15 min preoperatively (group III, n=15), and no oral 
      premedication administration [group IV (controls), n=15]. Peripheral oxygen
      saturation (SpO2) and heart rate were monitored with a pulse oximeter during
      treatment. The sedation level was monitored with the bispectral index. Following 
      premedication, 40% N2O and 60% O2 was administered to all groups by means of a
      nasal mask. Sedation depth was evaluated using the Ramsay Sedation Scale and data
      were recorded at 5 min intervals. Sedation success and other sedation-related
      events were recorded. RESULTS: The evaluation of the findings of this study
      revealed that treatment procedures were completed without any serious
      complications. Achievement of sedation in terms of satisfactory/mid-level
      satisfactory/unsatisfactory was as follows: 13.3/53.3/33.3% in group I; 54/20/26%
      in group II; 33.3/33.3/33.3% in group III, and 6.7/60/33.3% in group IV,
      respectively. Ramsay Sedation Scale results revealed that the most effective
      medication was 0.7 mg kg(-1) midazolam. CONCLUSION: It is concluded that 0.7 mg
      kg(-1) midazolam is more effective than 0.25 mg kg(-1) midazolam with 3 mg kg(-1)
      ketamine and 1 mg kg(-1) hydroxyzine hydrochloride in terms of oral premedication
      prior to N2O/O2 sedation in children scheduled for dental treatments.
FAU - Baygin, Ozgul
AU  - Baygin O
AD  - Department of Pediatric Dentistry, Faculty of Dentistry, Karadeniz Technical
      University, Trabzon, Turkey. dtozgul@yahoo.com
FAU - Bodur, Haluk
AU  - Bodur H
FAU - Isik, Berrin
AU  - Isik B
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - Eur J Anaesthesiol
JT  - European journal of anaesthesiology
JID - 8411711
RN  - 0 (Anesthetics)
RN  - 0 (Anesthetics, Intravenous)
RN  - 0 (Histamine H1 Antagonists)
RN  - 30S50YM8OG (Hydroxyzine)
RN  - 690G0D6V8H (Ketamine)
RN  - K50XQU1029 (Nitrous Oxide)
RN  - R60L0SM5BC (Midazolam)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Anesthetics/*administration & dosage
MH  - Anesthetics, Intravenous/administration & dosage
MH  - Child
MH  - Child, Preschool
MH  - Conscious Sedation/*methods
MH  - Double-Blind Method
MH  - Electroencephalography/drug effects
MH  - Female
MH  - Heart Rate/drug effects
MH  - Histamine H1 Antagonists/administration & dosage
MH  - Humans
MH  - Hydroxyzine/administration & dosage
MH  - Ketamine/*administration & dosage
MH  - Male
MH  - Midazolam/*administration & dosage
MH  - Neuropsychological Tests
MH  - Nitrous Oxide/*administration & dosage
MH  - Oral Surgical Procedures/psychology
MH  - Oxygen/administration & dosage/blood
MH  - Premedication
MH  - Treatment Outcome
EDAT- 2010/01/22 06:00
MHDA- 2010/11/04 06:00
CRDT- 2010/01/22 06:00
PHST- 2010/01/22 06:00 [entrez]
PHST- 2010/01/22 06:00 [pubmed]
PHST- 2010/11/04 06:00 [medline]
AID - 10.1097/EJA.0b013e3283313cdd [doi]
PST - ppublish
SO  - Eur J Anaesthesiol. 2010 Apr;27(4):341-6. doi: 10.1097/EJA.0b013e3283313cdd.


PMID- 20089723
OWN - NLM
STAT- MEDLINE
DCOM- 20100225
LR  - 20170916
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 254
IP  - 2
DP  - 2010 Feb
TI  - Low to intermediate probability of coronary artery disease: comparison of
      coronary CT angiography with first-pass MR myocardial perfusion imaging.
PG  - 384-92
LID - 10.1148/radiol.09090802 [doi]
AB  - PURPOSE: To compare coronary computed tomographic (CT) angiography with
      first-pass magnetic resonance (MR) myocardial perfusion imaging in patients with 
      chest pain and low to intermediate probability of coronary artery disease (CAD). 
      MATERIALS AND METHODS: Local ethics committee approval and patient written
      informed consent were obtained. Patients with chest pain and low to intermediate 
      pretest probability of CAD underwent both coronary CT angiography and MR
      myocardial perfusion imaging. Coronary CT angiographic and MR myocardial
      perfusion images were analyzed qualitatively by blinded observers. Obstructive
      CAD was defined as more than 50% diameter stenosis at coronary CT angiography.
      Data were expressed with 95% confidence intervals (CIs) calculated from binomial 
      expression. RESULTS: In 145 (94.2%) of 154 eligible patients, both coronary CT
      angiography and MR myocardial perfusion imaging were performed successfully. Mean
      age was 57 years +/- 10 (standard deviation), and 45.5% of patients were male.
      Mean interval between coronary CT angiography and MR myocardial perfusion imaging
      was 4.6 days +/- 3.0; median was 5.0 days. CT coronary angiography revealed
      obstructive CAD in 52 (35.9%) patients and 78 (17.9%) coronary arteries. At MR
      myocardial perfusion imaging, myocardial ischemia was demonstrated in 33 (22.8%) 
      patients and 59 (13.6%) vessel territories. Of patients without CAD at coronary
      CT angiography, 90.5% (57 of 63; 95% CI: 82.6%, 95.0%) had normal myocardial
      perfusion at MR myocardial perfusion imaging. Of patients with nonobstructive
      CAD, 83.3% (25 of 30; 95% CI: 69.5%, 91.6%) had normal myocardial perfusion at MR
      myocardial perfusion imaging. Myocardial ischemia was detected at MR myocardial
      perfusion imaging in 42.3% (22 of 52; 95% CI: 29.5%, 56%) of patients with
      obstructive CAD at coronary CT angiography. CONCLUSION: MR myocardial perfusion
      imaging and coronary CT angiography have complementary roles in evaluation of
      patients who are suspected of having CAD. Coronary CT angiography can be used to 
      reliably rule out CAD, but its capability to demonstrate hemodynamically
      significant CAD is limited. The combination of both techniques enables the
      clinician to evaluate morphology and functional relevance of CAD comprehensively 
      and noninvasively.
CI  - (c) RSNA, 2010.
FAU - Groothuis, Jan G J
AU  - Groothuis JG
AD  - Department of Cardiology, VU University Medical Center, De Boelelaan 1117, Room
      5F003, 1081 HV Amsterdam, the Netherlands. j.groothuis@vumc.nl
FAU - Beek, Aernout M
AU  - Beek AM
FAU - Brinckman, Stijn L
AU  - Brinckman SL
FAU - Meijerink, Martijn R
AU  - Meijerink MR
FAU - Koestner, Simon C
AU  - Koestner SC
FAU - Nijveldt, Robin
AU  - Nijveldt R
FAU - Gotte, Marco J W
AU  - Gotte MJ
FAU - Hofman, Mark B M
AU  - Hofman MB
FAU - van Kuijk, Cornelis
AU  - van Kuijk C
FAU - van Rossum, Albert C
AU  - van Rossum AC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100120
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - 4419T9MX03 (Iohexol)
RN  - 712BAC33MZ (iopromide)
SB  - IM
CIN - Radiologe. 2010 Aug;50(8):649-50. PMID: 20683568
MH  - Artifacts
MH  - Chest Pain/*diagnosis/*diagnostic imaging/epidemiology
MH  - Confidence Intervals
MH  - Contrast Media
MH  - Coronary Angiography/*methods
MH  - Coronary Disease/*diagnosis/*diagnostic imaging/epidemiology
MH  - Female
MH  - Humans
MH  - Iohexol/analogs & derivatives
MH  - Magnetic Resonance Angiography/*methods
MH  - Male
MH  - Middle Aged
MH  - Probability
MH  - Sensitivity and Specificity
MH  - *Tomography, X-Ray Computed
EDAT- 2010/01/22 06:00
MHDA- 2010/02/26 06:00
CRDT- 2010/01/22 06:00
PHST- 2010/01/22 06:00 [entrez]
PHST- 2010/01/22 06:00 [pubmed]
PHST- 2010/02/26 06:00 [medline]
AID - radiol.09090802 [pii]
AID - 10.1148/radiol.09090802 [doi]
PST - ppublish
SO  - Radiology. 2010 Feb;254(2):384-92. doi: 10.1148/radiol.09090802. Epub 2010 Jan
      20.


PMID- 20089720
OWN - NLM
STAT- MEDLINE
DCOM- 20100415
LR  - 20140730
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 254
IP  - 3
DP  - 2010 Mar
TI  - Distribution of cerebral blood flow in the nucleus caudatus, nucleus lentiformis,
      and thalamus: a study of territorial arterial spin-labeling MR imaging.
PG  - 867-75
LID - 10.1148/radiol.09090284 [doi]
AB  - PURPOSE: To investigate the effect of variations in anatomic features of the
      circle of Willis on the perfusion territory to deep structures, including the
      nucleus caudatus, the nucleus lentiformis, and the thalamus. MATERIALS AND
      METHODS: The ethics committee of the study institution approved the study
      protocol. A total of 159 patients with first-time clinical symptoms of cerebral
      ischemia were recruited. Contributions to the perfusion territory were visualized
      with territorial arterial spin-labeling magnetic resonance (MR) imaging. The
      anatomic features of the circle of Willis were evaluated with time-of-flight MR
      angiography. Perfusion territory contributions were compared among circle of
      Willis variants by using the Cochran-Mantel-Haenszel test. RESULTS: The perfusion
      territory contributions to the deep-brain structures could be evaluated in 119 of
      159 patients (75%). With a fetal-type circle of Willis (41 of 238 hemispheres;
      17%), there was a contribution from the ipsilateral internal carotid artery to
      the thalamus in all 41 hemispheres (100%), compared with 96 of the 197
      hemispheres (49%) without a fetal-type circle of Willis. In the 19 patients with 
      a hypoplastic A1 segment, there was more often a contribution of the
      contralateral internal carotid artery to the perfusion of the nucleus caudatus
      (10 of 19; 53%) and the nucleus lentiformis (5 of 19; 26%). CONCLUSION: The
      perfusion territory contributions to deep-brain structures vary widely. These
      differences can be partly explained by variations in the anatomic features of the
      circle of Willis. (c) RSNA, 2010.
FAU - Hendrikse, Jeroen
AU  - Hendrikse J
AD  - Department of Radiology, University Medical Center Utrecht, Utrecht, the
      Netherlands.
FAU - Petersen, Esben Thade
AU  - Petersen ET
FAU - Chng, Soke Miang
AU  - Chng SM
FAU - Venketasubramanian, Narayanaswamy
AU  - Venketasubramanian N
FAU - Golay, Xavier
AU  - Golay X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100120
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Spin Labels)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Caudate Nucleus/*blood supply
MH  - *Cerebrovascular Circulation
MH  - Corpus Striatum/*blood supply
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Linear Models
MH  - Logistic Models
MH  - Magnetic Resonance Angiography/*methods
MH  - Male
MH  - Middle Aged
MH  - Spin Labels
MH  - Thalamus/*blood supply
EDAT- 2010/01/22 06:00
MHDA- 2010/04/16 06:00
CRDT- 2010/01/22 06:00
PHST- 2010/01/22 06:00 [entrez]
PHST- 2010/01/22 06:00 [pubmed]
PHST- 2010/04/16 06:00 [medline]
AID - radiol.09090284 [pii]
AID - 10.1148/radiol.09090284 [doi]
PST - ppublish
SO  - Radiology. 2010 Mar;254(3):867-75. doi: 10.1148/radiol.09090284. Epub 2010 Jan
      20.


PMID- 20089635
OWN - NLM
STAT- MEDLINE
DCOM- 20100413
LR  - 20100121
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 1
DP  - 2010 Jan
TI  - A code of ethics for nurse educators: revised.
PG  - 137-9
LID - 10.1177/0969733009350946 [doi]
AB  - Nurse educators have the responsibility of assisting students and their
      colleagues with understanding and practicing ethical conduct. There is an
      inherent responsibility to keep codes current and relevant for existing nursing
      practice. The code presented here is a revision of the Code of ethics for nurse
      educators originally published in 1983 and includes changes that are intended to 
      provide for that relevancy.
FAU - Rosenkoetter, Marlene M
AU  - Rosenkoetter MM
AD  - Medical College of Georgia, GA, A. mrosenkoetter@knology.net
FAU - Milstead, Jeri A
AU  - Milstead JA
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - *Codes of Ethics
MH  - Education, Nursing/*ethics
MH  - Faculty, Nursing
MH  - Humans
MH  - United States
EDAT- 2010/01/22 06:00
MHDA- 2010/04/14 06:00
CRDT- 2010/01/22 06:00
PHST- 2010/01/22 06:00 [entrez]
PHST- 2010/01/22 06:00 [pubmed]
PHST- 2010/04/14 06:00 [medline]
AID - 17/1/137 [pii]
AID - 10.1177/0969733009350946 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 Jan;17(1):137-9. doi: 10.1177/0969733009350946.


PMID- 20089632
OWN - NLM
STAT- MEDLINE
DCOM- 20100413
LR  - 20161125
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 1
DP  - 2010 Jan
TI  - Nursing ethics: the last decade.
PG  - 127-31
LID - 10.1177/0969733009352408 [doi]
FAU - Tschudin, Verena
AU  - Tschudin V
AD  - International Centre for Nursing Ethics and founding Editor of Nursing Ethics.
      vtschudin@fastnet.co.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - *Ethics, Nursing
MH  - Humans
MH  - Periodicals as Topic/*trends
MH  - Publishing/*trends
MH  - United Kingdom
EDAT- 2010/01/22 06:00
MHDA- 2010/04/14 06:00
CRDT- 2010/01/22 06:00
PHST- 2010/01/22 06:00 [entrez]
PHST- 2010/01/22 06:00 [pubmed]
PHST- 2010/04/14 06:00 [medline]
AID - 17/1/127 [pii]
AID - 10.1177/0969733009352408 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 Jan;17(1):127-31. doi: 10.1177/0969733009352408.


PMID- 20089631
OWN - NLM
STAT- MEDLINE
DCOM- 20100413
LR  - 20100121
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 1
DP  - 2010 Jan
TI  - The role of community health advisors in community-based participatory research.
PG  - 117-26
LID - 10.1177/0969733009350261 [doi]
AB  - Mistrust and fear of research often exist in minority communities because of
      assumptions, preconceived ideas, and historical abuse and racism that continue to
      influence research participation. The research establishment is full of
      well-meaning 'outsider' investigators who recognize discrimination, health
      disparities, and insufficient health care providers in minority communities, but 
      struggle in breaking through this history of mistrust. This article provides
      ethical insights from one such 'insider-outsider', community-based participatory 
      research project implemented via community health advisors in the Mississippi
      Delta. Both community-based participatory research and community health advisors 
      provide opportunities to address the ethical issues of trust, non-maleficence,
      and justice in minority communities. Implications for ethics-driven nursing
      research are discussed.
FAU - Story, Lachel
AU  - Story L
AD  - University of Southern Mississippi, Hattiesburg, MS 39406, USA.
      lachel.story@usm.edu
FAU - Hinton, Agnes
AU  - Hinton A
FAU - Wyatt, Sharon B
AU  - Wyatt SB
LA  - eng
GR  - 1 P20 MD000534-01/MD/NIMHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - *Community-Based Participatory Research/ethics
MH  - *Community-Institutional Relations
MH  - Health Status Disparities
MH  - Humans
MH  - *Minority Groups
MH  - Mississippi
MH  - *Nursing Research/ethics
MH  - Patient Selection
MH  - *Trust
EDAT- 2010/01/22 06:00
MHDA- 2010/04/14 06:00
CRDT- 2010/01/22 06:00
PHST- 2010/01/22 06:00 [entrez]
PHST- 2010/01/22 06:00 [pubmed]
PHST- 2010/04/14 06:00 [medline]
AID - 17/1/117 [pii]
AID - 10.1177/0969733009350261 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 Jan;17(1):117-26. doi: 10.1177/0969733009350261.


PMID- 20089630
OWN - NLM
STAT- MEDLINE
DCOM- 20100413
LR  - 20100121
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 1
DP  - 2010 Jan
TI  - Legitimizing basic research by evaluating quality.
PG  - 107-16
LID - 10.1177/0969733009349989 [doi]
AB  - The aim of this study was to use ethical arguments to strengthen the relationship
      between the concepts of legitimacy and evaluation. The analysis is based on the
      ethics of Levinas and Buber and is motivated by a sense of responsibility using
      dialogical ideology as a mediator. The main questions in this study consider the 
      following: Does caring science as an independent academic discipline have the
      moral responsibility to develop a theory for evaluating the quality of basic
      research? and Will such a quality evaluation theory have a reasonable probability
      of introducing legitimization into caring science? On an ethical level, this
      study introduces a meaningful interaction inspired by social demands and is
      linked to the concept of research justification. Legitimization turns from an
      abstract idea to an achievable entity by an act. The act of evaluation has the
      likelihood of delegating legitimacy and empowers the foundation of caring
      science, which in turn will become a cornerstone of nursing. At this stage there 
      is no intention to develop an evaluation theory, rather to create a meaningful
      discussion for the future development of an ethics-based theory.
FAU - Levy-Malmberg, Rika
AU  - Levy-Malmberg R
AD  - Abo Academy University, Vaasa, Finland. rika.levy-malmberg@abo.fi
FAU - Eriksson, Katie
AU  - Eriksson K
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Bibliometrics
MH  - *Empathy
MH  - Humans
MH  - *Moral Obligations
MH  - Nursing Research/*ethics
MH  - Peer Review, Research
MH  - Quality Control
EDAT- 2010/01/22 06:00
MHDA- 2010/04/14 06:00
CRDT- 2010/01/22 06:00
PHST- 2010/01/22 06:00 [entrez]
PHST- 2010/01/22 06:00 [pubmed]
PHST- 2010/04/14 06:00 [medline]
AID - 17/1/107 [pii]
AID - 10.1177/0969733009349989 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 Jan;17(1):107-16. doi: 10.1177/0969733009349989.


PMID- 20089629
OWN - NLM
STAT- MEDLINE
DCOM- 20100413
LR  - 20220409
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 1
DP  - 2010 Jan
TI  - Validation of a Korean version of the Moral Sensitivity Questionnaire.
PG  - 99-105
LID - 10.1177/0969733009349993 [doi]
AB  - The main purpose of this study was to validate a scale to examine the moral
      sensitivity of Korean nurses. A pre-existing scale, the Moral Sensitivity
      Questionnaire (MSQ), developed by Lutzen, was used after deletion of three items.
      The reliability and validity of the scale were examined by using Cronbach's alpha
      and factor analysis, respectively. According to the results, reliability of the
      scale was adequate but its construct validity was not fully supported. Through
      discussion on evidence of validity, five subconstructs emerged. In particular,
      unlike the factor structure of the MSQ, two subconstructs, patient-oriented care 
      and professional responsibility, were newly extracted. It was assumed that the
      other three MSQ subconstructs, conflict, meaning and benevolence (expressed as
      nurses being ethically good), would not be sensitive to cultural background.
      Given these findings, interpretations about the meaning of moral sensitivity of
      Korean nurses are discussed.
FAU - Han, Sung-Suk
AU  - Han SS
AD  - Catholic University, Seoul, South Korea.
FAU - Kim, Juhu
AU  - Kim J
FAU - Kim, Yong-Soon
AU  - Kim YS
FAU - Ahn, Sunghee
AU  - Ahn S
LA  - eng
PT  - Journal Article
PT  - Validation Study
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Adult
MH  - *Ethics, Nursing
MH  - Factor Analysis, Statistical
MH  - Humans
MH  - Korea
MH  - *Morals
MH  - Nurses/*psychology
MH  - *Psychological Tests
MH  - Psychometrics
MH  - Reproducibility of Results
EDAT- 2010/01/22 06:00
MHDA- 2010/04/14 06:00
CRDT- 2010/01/22 06:00
PHST- 2010/01/22 06:00 [entrez]
PHST- 2010/01/22 06:00 [pubmed]
PHST- 2010/04/14 06:00 [medline]
AID - 17/1/99 [pii]
AID - 10.1177/0969733009349993 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 Jan;17(1):99-105. doi: 10.1177/0969733009349993.


PMID- 20089627
OWN - NLM
STAT- MEDLINE
DCOM- 20100413
LR  - 20100121
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 1
DP  - 2010 Jan
TI  - Compliance versus adherence in serious and persistent mental illness.
PG  - 77-85
LID - 10.1177/0969733009352047 [doi]
AB  - Failure to follow prescribed treatment has devastating consequences for those who
      are seriously and persistently mentally ill. Nurses, therefore, try to get
      clients to take psychotropic medication on a long-term basis. The goal is either 
      compliance or adherence. Although current nursing literature has abandoned the
      term compliance because of its implications of coercion, in psychiatric nursing
      practice with patients suffering from serious long-term mental illness compliance
      and adherence are in fact different goals. The ideal goal is adherence, which
      requires the patient to be an active participant in the team. This goal is
      consistent with nurses' ethical values, but for such patients this is frequently 
      unrealistic. If the person is severely psychotic, treatment may be involuntary
      and the goal compliance. Psychiatric nurses participate in involuntary treatment 
      and thus should acknowledge the ethical implications of compliance as a goal and 
      not obscure the issue by calling compliance adherence.
FAU - Vuckovich, Paula K
AU  - Vuckovich PK
AD  - California State University, Los Angeles CA 90032-8171, USA.
      pvuckov@calstatela.edu
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
RN  - 0 (Psychotropic Drugs)
MH  - Advance Directives
MH  - Chronic Disease
MH  - Coercion
MH  - Humans
MH  - *Medication Adherence
MH  - Mental Disorders/*drug therapy/nursing
MH  - Nurse-Patient Relations/*ethics
MH  - Psychiatric Nursing/ethics
MH  - Psychotropic Drugs/*therapeutic use
EDAT- 2010/01/22 06:00
MHDA- 2010/04/14 06:00
CRDT- 2010/01/22 06:00
PHST- 2010/01/22 06:00 [entrez]
PHST- 2010/01/22 06:00 [pubmed]
PHST- 2010/04/14 06:00 [medline]
AID - 17/1/77 [pii]
AID - 10.1177/0969733009352047 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 Jan;17(1):77-85. doi: 10.1177/0969733009352047.


PMID- 20089626
OWN - NLM
STAT- MEDLINE
DCOM- 20100413
LR  - 20151119
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 1
DP  - 2010 Jan
TI  - Patient restrictions: are there ethical alternatives to seclusion and restraint?
PG  - 65-76
LID - 10.1177/0969733009350140 [doi]
AB  - The use of patient restrictions (e.g. involuntary admission, seclusion,
      restraint) is a complex ethical dilemma in psychiatric care. The present study
      explored nurses' (n = 22) and physicians' (n = 5) perceptions of what actually
      happens when an aggressive behaviour episode occurs on the ward and what
      alternatives to seclusion and restraint are actually in use as normal standard
      practice in acute psychiatric care. The data were collected by focus group
      interviews and analysed by inductive content analysis. The participants believed 
      that the decision-making process for managing patients' aggressive behaviour
      contains some in-built ethical dilemmas. They thought that patients' subjective
      perspective received little attention. Nevertheless, the staff proposed and
      appeared to use a number of alternatives to minimize or replace the use of
      seclusion and restraint. Medical and nursing staff need to be encouraged and
      taught to: (1) tune in more deeply to reasons for patients' aggressive behaviour;
      and (2) use alternatives to seclusion and restraint in order to humanize patient 
      care to a greater extent.
FAU - Kontio, Raija
AU  - Kontio R
AD  - University of Turku, Turku, Finland, and Kellokoski Hospital, Tuusula, Finland.
      raija.kontio@hus.fi
FAU - Valimaki, Maritta
AU  - Valimaki M
FAU - Putkonen, Hanna
AU  - Putkonen H
FAU - Kuosmanen, Lauri
AU  - Kuosmanen L
FAU - Scott, Anne
AU  - Scott A
FAU - Joffe, Grigori
AU  - Joffe G
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Adult
MH  - *Aggression
MH  - Behavior Control/*ethics/*methods
MH  - Decision Making/ethics
MH  - Female
MH  - Finland
MH  - Focus Groups
MH  - Humans
MH  - Male
MH  - Mental Disorders/nursing/*therapy
MH  - Middle Aged
MH  - Patient Isolation/ethics
MH  - Pilot Projects
MH  - Practice Patterns, Nurses'/*ethics
MH  - Practice Patterns, Physicians'/*ethics
MH  - Restraint, Physical/ethics
EDAT- 2010/01/22 06:00
MHDA- 2010/04/14 06:00
CRDT- 2010/01/22 06:00
PHST- 2010/01/22 06:00 [entrez]
PHST- 2010/01/22 06:00 [pubmed]
PHST- 2010/04/14 06:00 [medline]
AID - 17/1/65 [pii]
AID - 10.1177/0969733009350140 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 Jan;17(1):65-76. doi: 10.1177/0969733009350140.


PMID- 20089625
OWN - NLM
STAT- MEDLINE
DCOM- 20100413
LR  - 20191210
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 1
DP  - 2010 Jan
TI  - Ethical issues in invasive mechanical ventilation for amyotrophic lateral
      sclerosis.
PG  - 51-63
LID - 10.1177/0969733009350945 [doi]
AB  - Currently in Japan, discontinuing an invasive mechanical ventilator (IMV) is
      illegal; therefore IMV-related decision making is a crucial issue. This study
      examined IMV decision-making factors and psychological conflict in 50 patients
      with amyotrophic lateral sclerosis. The Herth Hope Index was used for the
      assessment of pre- and post-IMV conflict. Interviews identified some
      decision-making factors: patient's decision, patient's and family's mutual
      decision, family's decision, and emergency-induced without patient's or family's 
      consent. Participants who experienced no IMV-related regret received sufficient
      prior IMV education from physicians and nurses, and time for reflection and
      family consultation. Their hope was similar to their pre-onset levels. Patients
      who received no prior IMV education accepted treatment as a natural progression. 
      Their hope levels were lower than pre-onset. Those who received only a brief
      prior IMV explanation rejected the ventilator, experiencing regret if they were
      given an emergency IMV. Their hope levels were among the lowest. However, some of
      these patients managed to overcome their regret through being helped by nurses.
      Sufficient physician explanation and nursing advocacy for autonomous patient
      decision making are critical for improving hope in this patient group.
FAU - Hirano, Yuko
AU  - Hirano Y
AD  - The University of Tokyo, Tokyo, Japan. yuuko-tky@umin.ac.jp
FAU - Yamazaki, Yoshihiko
AU  - Yamazaki Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - *Adaptation, Psychological
MH  - Adult
MH  - Aged
MH  - Amyotrophic Lateral Sclerosis/ethnology/*nursing/psychology/therapy
MH  - Conflict, Psychological
MH  - Decision Making/*ethics
MH  - Family Relations
MH  - Female
MH  - Humans
MH  - Japan
MH  - Life Support Care/*ethics/psychology
MH  - Male
MH  - Middle Aged
MH  - Personal Autonomy
MH  - Respiration, Artificial/*ethics/nursing/psychology
EDAT- 2010/01/22 06:00
MHDA- 2010/04/14 06:00
CRDT- 2010/01/22 06:00
PHST- 2010/01/22 06:00 [entrez]
PHST- 2010/01/22 06:00 [pubmed]
PHST- 2010/04/14 06:00 [medline]
AID - 17/1/51 [pii]
AID - 10.1177/0969733009350945 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 Jan;17(1):51-63. doi: 10.1177/0969733009350945.


PMID- 20089624
OWN - NLM
STAT- MEDLINE
DCOM- 20100413
LR  - 20191210
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 1
DP  - 2010 Jan
TI  - A phenomenological study of nurses' understanding of honesty in palliative care.
PG  - 39-50
LID - 10.1177/0969733009350952 [doi]
AB  - Honesty is essential for the care of seriously ill and dying patients. The
      current study aimed to describe how nurses experience honesty in their work with 
      patients receiving palliative care at home. The interviews in this
      phenomenological study were conducted with 16 nurses working with children and
      adults in palliative home-based care. Three categories emerged from analyses of
      the interviews: the meaning of honesty, the reason for being honest and, finally,
      moral conflict when dealing with honesty. The essence of these descriptions was
      that honesty is seen as a virtue, a good quality that a nurse should have. The
      nurses' ethical standpoint was shown in the moral character they show in their
      work and in their intention to do good. This study could help nurses to identify 
      different ways of looking at honesty to promote more consciousness and openness
      in ethical discussions between colleagues and other staff members.
FAU - Erichsen, Eva
AU  - Erichsen E
AD  - Vrinnevi Hospital, Norrkoping, Sweden and Linkoping University, 601 74
      Norrkoping, Sweden. eva.erichsen@lio.se
FAU - Danielsson, Elisabeth Hadd
AU  - Danielsson EH
FAU - Friedrichsen, Maria
AU  - Friedrichsen M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Child
MH  - Conflict, Psychological
MH  - Home Care Services/*ethics
MH  - Humans
MH  - Morals
MH  - Nurse-Patient Relations/*ethics
MH  - Palliative Care/*ethics
MH  - Sweden
MH  - Truth Disclosure/*ethics
EDAT- 2010/01/22 06:00
MHDA- 2010/04/14 06:00
CRDT- 2010/01/22 06:00
PHST- 2010/01/22 06:00 [entrez]
PHST- 2010/01/22 06:00 [pubmed]
PHST- 2010/04/14 06:00 [medline]
AID - 17/1/39 [pii]
AID - 10.1177/0969733009350952 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 Jan;17(1):39-50. doi: 10.1177/0969733009350952.


PMID- 20089621
OWN - NLM
STAT- MEDLINE
DCOM- 20100413
LR  - 20161125
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 17
IP  - 1
DP  - 2010 Jan
TI  - Is the 2008 NMC Code ethical?
PG  - 9-18
LID - 10.1177/0969733009349991 [doi]
AB  - In 2008 the United Kingdom Nursing and Midwifery Council (NMC) published the
      latest version of its code of conduct (The code: standards of conduct,
      performance and ethics for nurses and midwives). The new version marked a
      significant change of style in the Code compared with previous versions. There
      has been considerable controversy and the accrual of an extensive body of
      literature over the years in the UK and Europe criticizing nursing codes of
      ethics and questioning their ethical standing and their usefulness. In this
      article we review the current NMC Code. We argue that the NMC has been misguided 
      in labelling the Code as a code of ethics, and suggest that the new document
      falls short in many respects.
FAU - Pattison, Stephen
AU  - Pattison S
AD  - The University of Birmingham, Birmingham, UK.
FAU - Wainwright, Paul
AU  - Wainwright P
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - *Codes of Ethics
MH  - *Ethics, Nursing
MH  - Humans
MH  - Moral Obligations
MH  - Social Values
MH  - Terminology as Topic
MH  - United Kingdom
EDAT- 2010/01/22 06:00
MHDA- 2010/04/14 06:00
CRDT- 2010/01/22 06:00
PHST- 2010/01/22 06:00 [entrez]
PHST- 2010/01/22 06:00 [pubmed]
PHST- 2010/04/14 06:00 [medline]
AID - 17/1/9 [pii]
AID - 10.1177/0969733009349991 [doi]
PST - ppublish
SO  - Nurs Ethics. 2010 Jan;17(1):9-18. doi: 10.1177/0969733009349991.


PMID- 20089327
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20100811
IS  - 1872-7565 (Electronic)
IS  - 0169-2607 (Linking)
VI  - 99
IP  - 3
DP  - 2010 Sep
TI  - Strategies for health data exchange for secondary, cross-institutional clinical
      research.
PG  - 230-51
LID - 10.1016/j.cmpb.2009.12.001 [doi]
AB  - Secondary use of health data has a vital role in improving and advancing medical 
      knowledge. While digital health records offer scope for facilitating the flow of 
      data to secondary uses, it remains essential that steps are taken to respect
      wishes of the patient regarding secondary usage, and to ensure the privacy of the
      patient during secondary use scenarios. Consent, together with depersonalisation 
      and its related concepts of anonymisation, pseudonymisation, and data
      minimisation are key methods used to provide this protection. This paper gives an
      overview of technical, practical, legal, and ethical aspects of secondary data
      use and discusses their implementation in the multi-institutional @neurIST
      research project.
CI  - Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
FAU - Elger, Bernice S
AU  - Elger BS
AD  - University of Geneva, Switzerland.
FAU - Iavindrasana, Jimison
AU  - Iavindrasana J
FAU - Lo Iacono, Luigi
AU  - Lo Iacono L
FAU - Muller, Henning
AU  - Muller H
FAU - Roduit, Nicolas
AU  - Roduit N
FAU - Summers, Paul
AU  - Summers P
FAU - Wright, Jessica
AU  - Wright J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100120
PL  - Ireland
TA  - Comput Methods Programs Biomed
JT  - Computer methods and programs in biomedicine
JID - 8506513
SB  - IM
MH  - Access to Information/*ethics
MH  - Algorithms
MH  - *Biomedical Research
MH  - Computer Security
MH  - Computer Systems/ethics
MH  - Confidentiality/*ethics
MH  - Ethics, Medical
MH  - Humans
MH  - *Informed Consent
MH  - *Medical Records Systems, Computerized
MH  - Research Design
EDAT- 2010/01/22 06:00
MHDA- 2011/01/07 06:00
CRDT- 2010/01/22 06:00
PHST- 2008/08/19 00:00 [received]
PHST- 2009/11/12 00:00 [revised]
PHST- 2009/12/02 00:00 [accepted]
PHST- 2010/01/22 06:00 [entrez]
PHST- 2010/01/22 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
AID - S0169-2607(09)00304-6 [pii]
AID - 10.1016/j.cmpb.2009.12.001 [doi]
PST - ppublish
SO  - Comput Methods Programs Biomed. 2010 Sep;99(3):230-51. doi:
      10.1016/j.cmpb.2009.12.001. Epub 2010 Jan 20.


PMID- 20089187
OWN - NLM
STAT- MEDLINE
DCOM- 20100802
LR  - 20211020
IS  - 1471-2288 (Electronic)
IS  - 1471-2288 (Linking)
VI  - 10
DP  - 2010 Jan 20
TI  - Harnessing social networks along with consumer-driven electronic communication
      technologies to identify and engage members of 'hard-to-reach' populations: a
      methodological case report.
PG  - 8
LID - 10.1186/1471-2288-10-8 [doi]
AB  - BACKGROUND: Sampling in the absence of accurate or comprehensive information
      routinely poses logistical, ethical, and resource allocation challenges in social
      science, clinical, epidemiological, health service and population health
      research. These challenges are compounded if few members of a target population
      know each other or regularly interact. This paper reports on the sampling methods
      adopted in ethnographic case study research with a 'hard-to-reach' population.
      METHODS: To identify and engage a small yet diverse sample of people who met an
      unusual set of criteria (i.e., pet owners who had been treating cats or dogs for 
      diabetes), four sampling strategies were used. First, copies of a recruitment
      letter were posted in pet-friendly places. Second, information about the study
      was diffused throughout the study period via word of mouth. Third, the lead
      investigator personally sent the recruitment letter via email to a pet owner, who
      then circulated the information to others, and so on. Fourth, veterinarians were 
      enlisted to refer people who had diabetic pets. The second, third and fourth
      strategies rely on social networks and represent forms of chain referral
      sampling. RESULTS: Chain referral sampling via email proved to be the most
      efficient and effective, yielding a small yet diverse group of respondents within
      one month, and at negligible cost. CONCLUSIONS: The widespread popularity of
      electronic communication technologies offers new methodological opportunities for
      researchers seeking to recruit from hard-to-reach populations.
FAU - Rock, Melanie J
AU  - Rock MJ
AD  - Population Health Intervention Research Centre, University of Calgary, Calgary,
      Canada. mrock@ucalgary.ca
LA  - eng
GR  - CIHR-200609 MSH-83745/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100120
PL  - England
TA  - BMC Med Res Methodol
JT  - BMC medical research methodology
JID - 100968545
SB  - IM
MH  - Animals
MH  - Anthropology, Cultural
MH  - Cats
MH  - Diabetes Mellitus/*veterinary
MH  - Dogs
MH  - *Electronic Mail
MH  - Humans
MH  - Online Systems
MH  - *Patient Selection
MH  - *Sampling Studies
PMC - PMC2824147
EDAT- 2010/01/22 06:00
MHDA- 2010/08/03 06:00
CRDT- 2010/01/22 06:00
PHST- 2009/08/19 00:00 [received]
PHST- 2010/01/20 00:00 [accepted]
PHST- 2010/01/22 06:00 [entrez]
PHST- 2010/01/22 06:00 [pubmed]
PHST- 2010/08/03 06:00 [medline]
AID - 1471-2288-10-8 [pii]
AID - 10.1186/1471-2288-10-8 [doi]
PST - epublish
SO  - BMC Med Res Methodol. 2010 Jan 20;10:8. doi: 10.1186/1471-2288-10-8.


PMID- 20089072
OWN - NLM
STAT- MEDLINE
DCOM- 20100823
LR  - 20151119
IS  - 1600-9657 (Electronic)
IS  - 1600-4469 (Linking)
VI  - 26
IP  - 2
DP  - 2010 Apr
TI  - Traumatic dental injuries in primary dentition: epidemiological study among
      preschool children in South Brazil.
PG  - 168-73
LID - 10.1111/j.1600-9657.2009.00852.x [doi]
AB  - AIM: To estimate the prevalence of traumatic injury in primary dentition among
      children aged 12-71 months old, as well as to evaluate the distribution of
      traumatic injuries, type of trauma and associated factors. MATERIAL AND METHODS: 
      After the research project approval by the Ethics Research Committee, a
      cross-sectional study was carried out including 571 preschool children--both from
      public and private schools--in the city of Pelotas, Southern Brazil. Data were
      collected by means of anterior teeth examination, and by the administration of a 
      structured questionnaire to parents. The classification proposed by Andreasen &
      Andreasen was used, and crown discoloration and fistula were added to this
      criterion. RESULTS AND CONCLUSIONS: The prevalence of dental trauma was 36.6%
      (95% CI 32.7-40.5), with no significant differences between boys and girls.
      Trauma were more frequent among older children (P = 0.001). No associations were 
      found for maternal schooling, income and type of school. The most frequent trauma
      was enamel fracture, and the most affected tooth was number 61. A significant
      statistical association was observed between the presence of dental trauma during
      clinical examination and parental report of trauma occurrence. The percentage of 
      parents who looked for dental treatment was higher among children from private
      schools (P = 0.001). The most frequent place of occurrence was home, and the most
      frequently reported etiology was child's own-height fall. CONCLUSIONS: Dental
      trauma in primary teeth is characterized as an accident that occurs due to the
      children's development stage, even when they are cared for by mothers of higher
      schooling and income. Parents should search for assistance right after trauma
      occurrence to minimize sequelae.
FAU - Wendt, Flavia Prietsch
AU  - Wendt FP
AD  - Pediatric Dentistry at the Federal University of Pelotas, Pelotas, RS, Brazil.
FAU - Torriani, Dione Dias
AU  - Torriani DD
FAU - Assuncao, Maria Cecilia Formoso
AU  - Assuncao MC
FAU - Romano, Ana Regina
AU  - Romano AR
FAU - Bonow, Maria Laura Menezes
AU  - Bonow ML
FAU - da Costa, Catiara Terra
AU  - da Costa CT
FAU - Goettems, Marilia Leao
AU  - Goettems ML
FAU - Hallal, Pedro Curi
AU  - Hallal PC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100119
PL  - Denmark
TA  - Dent Traumatol
JT  - Dental traumatology : official publication of International Association for
      Dental Traumatology
JID - 101091305
MH  - Accidental Falls/statistics & numerical data
MH  - Accidents, Home/statistics & numerical data
MH  - Brazil/epidemiology
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Dental Enamel/injuries
MH  - Educational Status
MH  - Female
MH  - Humans
MH  - Incisor/injuries
MH  - Infant
MH  - Male
MH  - Prevalence
MH  - Schools, Nursery
MH  - Social Class
MH  - Surveys and Questionnaires
MH  - Tooth Discoloration/epidemiology
MH  - Tooth Injuries/*epidemiology/etiology
MH  - Tooth, Deciduous/injuries
EDAT- 2010/01/22 06:00
MHDA- 2010/08/24 06:00
CRDT- 2010/01/22 06:00
PHST- 2010/01/22 06:00 [entrez]
PHST- 2010/01/22 06:00 [pubmed]
PHST- 2010/08/24 06:00 [medline]
AID - EDT852 [pii]
AID - 10.1111/j.1600-9657.2009.00852.x [doi]
PST - ppublish
SO  - Dent Traumatol. 2010 Apr;26(2):168-73. doi: 10.1111/j.1600-9657.2009.00852.x.
      Epub 2010 Jan 19.


PMID- 20089054
OWN - NLM
STAT- MEDLINE
DCOM- 20100614
LR  - 20100503
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 10
IP  - 1
DP  - 2010 Apr
TI  - Fines, orders, fear . . . and consent? Medical research in East Africa, C. 1950s.
PG  - 34-41
LID - 10.1111/j.1471-8847.2009.00274.x [doi]
AB  - This article reconstructs the history of medical research in East Africa (Kenya, 
      Tanganyika, Uganda), laying out the lies, rumours, and oppressive techniques that
      made research such a fraught enterprise during the colonial era. The focus is on 
      the beginning stages of medical research: researchers' arrivals, villagers'
      responses, the gathering of subjects and consent. New archival and oral sources
      gathered in East Africa illuminate the research encounter and reintegrate the
      perspective of villagers cum subjects. Data from the 1950s shows that upon
      arrival in a village, researchers regularly lied in order to avoid sensitive
      topics and sidestep potential opposition. Misinformation fuelled villagers'
      fears, skepticism and rumours of blood stealing researchers. When it came to
      gathering subjects, researchers were rarely involved in the challenging work of
      enticing villagers to participate, preferring to rely on chiefs. Chiefs, however,
      often relied on heavy-handed and ethically questionable techniques. The article
      concludes by looking at the much-discussed concept of group consent, and showing 
      that historically a chief never had the authority to consent on behalf of
      villagers.
FAU - Graboyes, Melissa
AU  - Graboyes M
AD  - African Studies Center, 232 Bay State Road, Boston University. Boston, MA 02215, 
      USA. graboyes@bu.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20100118
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
SB  - IM
MH  - Africa, Eastern
MH  - Biomedical Research/*ethics
MH  - Deception
MH  - Ethics, Research
MH  - Fear
MH  - Humans
MH  - Informed Consent/*ethics/standards
MH  - Patient Selection/*ethics
MH  - Research Personnel/*ethics
MH  - Researcher-Subject Relations/*ethics
EDAT- 2010/01/22 06:00
MHDA- 2010/06/15 06:00
CRDT- 2010/01/22 06:00
PHST- 2010/01/22 06:00 [entrez]
PHST- 2010/01/22 06:00 [pubmed]
PHST- 2010/06/15 06:00 [medline]
AID - DEWB274 [pii]
AID - 10.1111/j.1471-8847.2009.00274.x [doi]
PST - ppublish
SO  - Dev World Bioeth. 2010 Apr;10(1):34-41. doi: 10.1111/j.1471-8847.2009.00274.x.
      Epub 2010 Jan 18.


PMID- 20088987
OWN - NLM
STAT- MEDLINE
DCOM- 20100325
LR  - 20211020
IS  - 1747-4949 (Electronic)
IS  - 1747-4930 (Linking)
VI  - 5
IP  - 1
DP  - 2010 Feb
TI  - Patient outcomes in historical comparators compared with randomised-controlled
      trials.
PG  - 10-5
LID - 10.1111/j.1747-4949.2009.00393.x [doi]
AB  - BACKGROUND: Decompressive hemicraniectomy for malignant middle cerebral artery
      infarction has long been controversial. Recently, data from randomised-controlled
      trials have shown that the procedure is life-saving and improves outcome.
      However, these randomised-controlled trials were difficult to conduct, because of
      ethical considerations due to high mortality in control groups. While the use of 
      historical comparators may not be ideal for phase III efficacy trials, these data
      may be useful to inform the selection of trial populations. We sought to
      replicate the findings of the DESTINY trial of decompressive surgery in malignant
      middle cerebral artery infarction using the Virtual International Stroke Trials
      Archive, to determine whether historical comparators could be used as an
      alternative to control groups in situations where randomised-controlled trials
      are infeasible or regarded as unethical due to the high mortality under
      conservative treatment. METHODS: We extracted data on patients from Virtual
      International Stroke Trials Archive who displayed signs of malignant middle
      cerebral artery infarction (baseline National Institutes of Health Stroke Scale> 
      or =20, LOC1A score of > or =1 on the National Institutes of Health Stroke Scale 
      at baseline, lesion volume > or =145 cm(3)). We used a chi(2)-test and logistic
      regression (adjusting for baseline National Institutes of Health Stroke Scale) to
      compare the functional outcomes (modified Rankin scores and Barthel index) at the
      last available follow-up assessment between the DESTINY surgical and the Virtual 
      International Stroke Trials Archive comparator groups. We assessed 90-day
      survival rates using a Kaplan-Meier analysis and Cox proportional hazards
      modelling (adjusting for the baseline National Institutes of Health Stroke Scale 
      score). RESULTS: Fewer patients in the Virtual International Stroke Trials
      Archive comparator group (n=6/32, 19% with a 90-day follow-up) achieved a good
      functional outcome by mRS at the final follow-up, when compared with the DESTINY 
      surgical group (n=8/17, 47% with a 6-month follow-up; chi(2)-test, P=0.04). This 
      difference persisted after adjusting for baseline National Institutes of Health
      Stroke Scale (logistic regression, P=0.04), but not when accounting for patient
      age (P=0.66). Analysis of Barthel index at the final follow-up revealed no
      significant difference between the two groups (chi(2)-test, P=0.07), although a
      trend towards a better outcome in the DESTINY group was observed. In contrast
      with the findings of the DESTINY trial, we found no significant difference in
      90-day survival rates between the surgical (88%) and the Virtual International
      Stroke Trials Archive (72%) comparator groups (Cox proportional hazards model,
      P=0.24). CONCLUSION: The beneficial effects of decompressive hemicraniectomy on
      survival were not confirmed using a historical comparator dataset. Our
      observations might be due to the fact that patients with malignant middle
      cerebral artery infarction are usually excluded from clinical trials of drug
      efficacy, and patients identified from Virtual International Stroke Trials
      Archive may not have been truly representative of patients with malignant middle 
      cerebral artery infarction. This mismatch could be rectified through recruitment 
      of population-based studies and stroke registries to Virtual International Stroke
      Trials Archive to increase the number of patients eligible for entry into the
      comparator patient data pool.
FAU - Ali, M
AU  - Ali M
AD  - Division of Cardiovascular and Medical Sciences, Gardiner Institute, Western
      Infirmary, Glasgow, UK. myzoonali@clinmed.gla.ac.uk
FAU - Juttler, E
AU  - Juttler E
FAU - Lees, K R
AU  - Lees KR
FAU - Hacke, W
AU  - Hacke W
FAU - Diedler, J
AU  - Diedler J
CN  - VISTA and DESTINY Investigators
LA  - eng
GR  - NMAHP2/CSO_/Chief Scientist Office/United Kingdom
PT  - Journal Article
PL  - United States
TA  - Int J Stroke
JT  - International journal of stroke : official journal of the International Stroke
      Society
JID - 101274068
SB  - IM
MH  - Adult
MH  - Computer Simulation
MH  - Craniotomy
MH  - Data Interpretation, Statistical
MH  - Databases, Factual
MH  - Decompression, Surgical
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Infarction, Middle Cerebral Artery/surgery/therapy
MH  - Kaplan-Meier Estimate
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Neurosurgical Procedures
MH  - Proportional Hazards Models
MH  - *Randomized Controlled Trials as Topic
MH  - *Research Design
MH  - Stroke/surgery/*therapy
MH  - Survival Analysis
MH  - *Treatment Outcome
IR  - Lees KR
FIR - Lees, K R
IR  - Bath PM
FIR - Bath, P M W
IR  - Bluhmki E
FIR - Bluhmki, E
IR  - Claesson L
FIR - Claesson, L
IR  - Curram J
FIR - Curram, J
IR  - Davis SM
FIR - Davis, S M
IR  - Diener HC
FIR - Diener, H C
IR  - Donnan GA
FIR - Donnan, G A
IR  - Fisher M
FIR - Fisher, M
IR  - Gregson BA
FIR - Gregson, B A
IR  - Grotta J
FIR - Grotta, J
IR  - Hacke W
FIR - Hacke, W
IR  - Hennerici MG
FIR - Hennerici, M G
IR  - Hommel M
FIR - Hommel, M
IR  - Kaste M
FIR - Kaste, M
IR  - Lyden P
FIR - Lyden, P
IR  - Marler J
FIR - Marler, J
IR  - Muir K
FIR - Muir, K
IR  - Sacco RL
FIR - Sacco, R L
IR  - Shuaib A
FIR - Shuaib, A
IR  - Teal P
FIR - Teal, P
IR  - Wahlgren NG
FIR - Wahlgren, N G
IR  - Warach S
FIR - Warach, S
IR  - Weimar C
FIR - Weimar, C
EDAT- 2010/01/22 06:00
MHDA- 2010/03/26 06:00
CRDT- 2010/01/22 06:00
PHST- 2010/01/22 06:00 [entrez]
PHST- 2010/01/22 06:00 [pubmed]
PHST- 2010/03/26 06:00 [medline]
AID - IJS393 [pii]
AID - 10.1111/j.1747-4949.2009.00393.x [doi]
PST - ppublish
SO  - Int J Stroke. 2010 Feb;5(1):10-5. doi: 10.1111/j.1747-4949.2009.00393.x.


PMID- 20088955
OWN - NLM
STAT- MEDLINE
DCOM- 20100916
LR  - 20100611
IS  - 1365-2516 (Electronic)
IS  - 1351-8216 (Linking)
VI  - 16
IP  - 3
DP  - 2010 May
TI  - Patient resources in the therapeutic education of haemophiliacs in France: their 
      skills and roles as defined by consensus of a working group.
PG  - 447-54
LID - 10.1111/j.1365-2516.2009.02163.x [doi]
AB  - The activities of 'expert patients' or 'patient tutors', who help educate their
      peers, are gaining recognition in the health care system. This study investigates
      the role played by such patients in therapeutic education programmes organized by
      caregivers to validate the role of patients in implementing the therapeutic
      education of haemophilic patients and to define the skills required for such
      activities. This study employs the consensus methodology recommended by France's 
      National Authority for Health. The working group includes seven caregivers from
      Hemophiliac Treatment Centers (HTCs) and three patients from the French
      Association of Hemophiliacs (FAH). The role of patients in haemophilia education 
      is recognized. Patients participating in the education of their peers are
      referred to as 'patient resources'. A patient resource should be an adult, a
      volunteer and live in the same region as his peers. Candidates are chosen by the 
      FAH and the HTCs to serve based on their motivation to facilitate the education
      of other patients as well as on their psychological and pedagogical aptitudes. A 
      patient resource participates in the conception and administration of therapeutic
      education programmes. He also mediates between the caregivers and the patients.
      He ensures that the patients understand the material and are able to apply their 
      knowledge in daily life. His activities are governed by professional ethics.
      Seven categories of skills were defined, permitting the group to determine
      precisely which skills are required to function as a patient resource.
      Supervision of the patients is planned to reinforce reflexive practices in the
      patients. Evolution of the health care system has led patients to become involved
      in therapeutic education. This phenomenon calls for a framework to be developed
      and an evaluation of its eventual effects.
FAU - Wintz, L
AU  - Wintz L
AD  - Health Education Laboratory, EA-3412 Paris 13 University, Bobigny, France.
      gagnayre@univ-paris13.fr
FAU - Sannie, T
AU  - Sannie T
FAU - Aycaguer, S
AU  - Aycaguer S
FAU - Guerois, C
AU  - Guerois C
FAU - Bernhard, J-P
AU  - Bernhard JP
FAU - Valluet, D
AU  - Valluet D
FAU - Borel-Derlon, A
AU  - Borel-Derlon A
FAU - Guillon, P
AU  - Guillon P
FAU - Fondanesche, C
AU  - Fondanesche C
FAU - Lambert, T
AU  - Lambert T
FAU - Meunier, S
AU  - Meunier S
FAU - Alliaume, N
AU  - Alliaume N
FAU - Gagnayre, R
AU  - Gagnayre R
LA  - eng
PT  - Journal Article
DEP - 20100118
PL  - England
TA  - Haemophilia
JT  - Haemophilia : the official journal of the World Federation of Hemophilia
JID - 9442916
SB  - IM
MH  - Consensus
MH  - France
MH  - Hemophilia A/*therapy
MH  - Hemophilia B/*therapy
MH  - Humans
MH  - Patient Education as Topic/*methods
MH  - *Patient Participation
MH  - Peer Group
MH  - Role
EDAT- 2010/01/22 06:00
MHDA- 2010/09/18 06:00
CRDT- 2010/01/22 06:00
PHST- 2010/01/22 06:00 [entrez]
PHST- 2010/01/22 06:00 [pubmed]
PHST- 2010/09/18 06:00 [medline]
AID - HAE2163 [pii]
AID - 10.1111/j.1365-2516.2009.02163.x [doi]
PST - ppublish
SO  - Haemophilia. 2010 May;16(3):447-54. doi: 10.1111/j.1365-2516.2009.02163.x. Epub
      2010 Jan 18.


PMID- 20088855
OWN - NLM
STAT- MEDLINE
DCOM- 20100803
LR  - 20220317
IS  - 1526-4637 (Electronic)
IS  - 1526-2375 (Linking)
VI  - 11
IP  - 3
DP  - 2010 Mar
TI  - Intractable end-of-life suffering and the ethics of palliative sedation.
PG  - 435-8
LID - 10.1111/j.1526-4637.2009.00786.x [doi]
AB  - Palliative sedation (sedation to unconsciousness) as an option of last resort for
      intractable end-of-life distress has been the subject of ongoing discussion and
      debate as well as policy formulation. A particularly contentious issue has been
      whether some dying patients experience a form of intractable suffering not marked
      by physical symptoms that can reasonably be characterized as "existential" in
      nature and therefore not an acceptable indication for palliative sedation. Such
      is the position recently taken by the American Medical Association. In this essay
      we argue that such a stance reflects a fundamental misunderstanding of the nature
      of human suffering, particularly at the end of life, and may deprive some dying
      patients of an effective means of relieving their intractable terminal distress.
FAU - Cassell, Eric J
AU  - Cassell EJ
AD  - Weill Cornell Medical College, New York, NY, USA.
FAU - Rich, Ben A
AU  - Rich BA
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100115
PL  - England
TA  - Pain Med
JT  - Pain medicine (Malden, Mass.)
JID - 100894201
RN  - 0 (Hypnotics and Sedatives)
SB  - IM
CIN - Pain Med. 2010 Mar;11(3):439; discussion 442. PMID: 20447310
CIN - Pain Med. 2010 Mar;11(3):440-1; discussion 442. PMID: 20447311
MH  - American Medical Association
MH  - Humans
MH  - Hypnotics and Sedatives/*therapeutic use
MH  - *Pain
MH  - Pain, Intractable/therapy
MH  - Palliative Care/*ethics
MH  - Terminal Care
MH  - Terminology as Topic
MH  - United States
RF  - 17
EDAT- 2010/01/22 06:00
MHDA- 2010/08/04 06:00
CRDT- 2010/01/22 06:00
PHST- 2010/01/22 06:00 [entrez]
PHST- 2010/01/22 06:00 [pubmed]
PHST- 2010/08/04 06:00 [medline]
AID - PME786 [pii]
AID - 10.1111/j.1526-4637.2009.00786.x [doi]
PST - ppublish
SO  - Pain Med. 2010 Mar;11(3):435-8. doi: 10.1111/j.1526-4637.2009.00786.x. Epub 2010 
      Jan 15.


PMID- 20088645
OWN - NLM
STAT- MEDLINE
DCOM- 20100226
LR  - 20100121
IS  - 1600-0455 (Electronic)
IS  - 0284-1851 (Linking)
VI  - 51
IP  - 1
DP  - 2010 Feb
TI  - A pilot study to assess the feasibility of measurement of adrenal gland volume by
      magnetic resonance imaging.
PG  - 117-20
LID - 10.3109/02841850903352620 [doi]
AB  - BACKGROUND: Repeated computed tomography (CT) assessment of the adrenal glands is
      associated with a significant radiation burden. The increasing capabilities of
      magnetic resonance (MR) volumetric analysis of the adrenals make this a
      potentially alternative technique in man. PURPOSE: To determine whether MR
      imaging could be used to measure adrenal volume, and to determine the intra- and 
      interobserver variation and repeatability of MR volume imaging of adrenals in
      healthy human subjects. MATERIAL AND METHODS: This was a single-cohort,
      sequential design, three-part study involving four MRI examinations per subject
      following ethical approval and informed consent. Information was collected on
      four healthy subjects (three male and one female). Two different investigators
      estimated the area of the adrenal gland for each of the 3-mm contiguous slices
      (and consequently adrenal volume). In order to estimate inter- and intrareader
      variability, a repeated-measures mixed model was fitted with adrenal volume as
      the dependent variable. In order to estimate any bias between readers,
      Bland-Altman methodology was applied. RESULTS: Intraobserver variation for
      adrenal gland volume is approximately 5% of a 3-cm(3 )adrenal gland.
      Interobserver variation is approximately 9% of a 3-cm(3) adrenal gland. Potential
      variation in measurement for adrenal volume from all sources equates to
      approximately 14% of a 3-cm(3) adrenal gland. Verification of image reading by a 
      second investigator (consensus reading) reduces variability. CONCLUSION: Analysis
      of adrenal gland volume using MRI is a potentially reliable technique that could 
      be used to assess a pathological change in adrenal size.
FAU - Grant, Lee A
AU  - Grant LA
AD  - Department of Radiology, Cambridge University Teaching Hospitals NHS Foundation
      Trust, Cambridge, United Kingdom. leegrant100@gmail.com
FAU - Napolitano, Antonella
AU  - Napolitano A
FAU - Miller, Sam
AU  - Miller S
FAU - Stephens, Kimberley
AU  - Stephens K
FAU - McHugh, Simon M
AU  - McHugh SM
FAU - Dixon, Adrian K
AU  - Dixon AK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Acta Radiol
JT  - Acta radiologica (Stockholm, Sweden : 1987)
JID - 8706123
SB  - IM
MH  - Adolescent
MH  - Adrenal Glands/*anatomy & histology
MH  - Adult
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Observer Variation
MH  - Pilot Projects
MH  - Prospective Studies
EDAT- 2010/01/22 06:00
MHDA- 2010/02/27 06:00
CRDT- 2010/01/22 06:00
PHST- 2010/01/22 06:00 [entrez]
PHST- 2010/01/22 06:00 [pubmed]
PHST- 2010/02/27 06:00 [medline]
AID - 10.3109/02841850903352620 [doi]
PST - ppublish
SO  - Acta Radiol. 2010 Feb;51(1):117-20. doi: 10.3109/02841850903352620.


PMID- 20087535
OWN - NLM
STAT- MEDLINE
DCOM- 20100429
LR  - 20161125
IS  - 0029-5566 (Print)
IS  - 0029-5566 (Linking)
VI  - 49
IP  - 1
DP  - 2010
TI  - [Benefit assessment of PET in malignant lymphomas. The IQWiG point of view].
PG  - 1-5
LID - 10.3413/nukmed-0320 [doi]
AB  - The call by the Institute for Quality and Efficiency in Health Care (IQWiG) for
      randomised controlled trials (RCTs) to prove the patient-relevant benefit of
      positron emission tomography (PET) is currently a controversial topic in Germany.
      From a methodological point of view there is essentially no difference between
      diagnostic procedures and therapeutic (drug or non-drug) interventions in proving
      their causal benefit. A broad consensus has been reached since the 1960s (e.g.
      FDA regulations) that RCTs are the methodological gold standard for therapeutic
      interventions. Nevertheless, the same arguments that were cited against RCTs in
      assessing the benefit of therapeutic interventions are now used against RCTs in
      evaluating diagnostic tests (e.g. ethical problems, feasibility, etc.). This
      paper summarizes the central methodological arguments of the discussion on the
      benefit assessment of PET in malignant lymphomas from the perspective of IQWiG
      and its external experts.
FAU - Scheibler, F
AU  - Scheibler F
AD  - Institut fur Qualitat und Wirtschaftlichkeit im Gesundheitswesen, Dillenburger
      Str. 27, 51105 Koln, Germany. fueloep.scheibler@iqwig.de
FAU - Raatz, H
AU  - Raatz H
FAU - Suter, K
AU  - Suter K
FAU - Janssen, I
AU  - Janssen I
FAU - Grosselfinger, R
AU  - Grosselfinger R
FAU - Schroer-Gunther, M
AU  - Schroer-Gunther M
FAU - Kunz, R
AU  - Kunz R
FAU - Lange, S
AU  - Lange S
LA  - ger
PT  - Journal Article
TT  - Nutzenbewertung der PET bei malignen Lymphomen - Standpunkt des IQWiG.
DEP - 20100119
PL  - Germany
TA  - Nuklearmedizin
JT  - Nuklearmedizin. Nuclear medicine
JID - 7609387
SB  - IM
CIN - Nuklearmedizin. 2010;49(1):6-12. PMID: 20087534
MH  - Evidence-Based Medicine/standards
MH  - Germany
MH  - Humans
MH  - Lymphoma/*diagnostic imaging
MH  - Positron-Emission Tomography/adverse effects/methods/*standards
MH  - Quality Assurance, Health Care
MH  - Radiography
MH  - Randomized Controlled Trials as Topic
MH  - *Risk Assessment
EDAT- 2010/01/21 06:00
MHDA- 2010/04/30 06:00
CRDT- 2010/01/21 06:00
PHST- 2009/10/15 00:00 [received]
PHST- 2009/10/20 00:00 [accepted]
PHST- 2010/01/21 06:00 [entrez]
PHST- 2010/01/21 06:00 [pubmed]
PHST- 2010/04/30 06:00 [medline]
AID - 0320 [pii]
AID - 10.3413/nukmed-0320 [doi]
PST - ppublish
SO  - Nuklearmedizin. 2010;49(1):1-5. doi: 10.3413/nukmed-0320. Epub 2010 Jan 19.


PMID- 20087238
OWN - NLM
STAT- MEDLINE
DCOM- 20100701
LR  - 20161125
IS  - 1473-5628 (Electronic)
IS  - 0143-3636 (Linking)
VI  - 31
IP  - 4
DP  - 2010 Apr
TI  - The effect of recombinant human TSH on 123I thyroid uptake after intravenous
      iodide contrast agent.
PG  - 315-9
LID - 10.1097/MNM.0b013e3283355c8b [doi]
AB  - BACKGROUND: Recombinant human thyroid stimulating hormone (rhTSH) increases the
      thyroid radioactive iodine uptake (RAIU) in euthyroid and multinodular goiter
      patients. Furthermore, rhTSH is a well-known complementary tool in the management
      and treatment of differentiated thyroid cancer patients. OBJECTIVE: To evaluate
      the effect of rhTSH on RAIU in subjects without thyroid disease exposed to
      iodinated contrast agent during computed tomography (CT). METHODS: Nine euthyroid
      patients, seven female and two male, with ages ranging from 22 to 58 years, have 
      signed a consent form approved by the hospital's Ethics Committee and had their
      TSH levels and RAIU evaluated in three moments: baseline (M1), 96 h after
      intravenous iodinated contrast agent (M2) and 24 h after intramuscular injection 
      of 0.1 mg of rhTSH (M3). Each patient acted as his own control. RESULTS: There
      was significant variation throughout the study of TSH (mean+/-SD): M1=2.39+/-0.92
      microUI/ml; M2=2.54+/-1.28 microUI/ml; M3=7.54+/-2.96 microUI/ml (P=0.004) and of
      RAIU (mean+/-SD): M1: 8.76+/-2.4%; M2=6.54+/-1.77%; M3=18.75+/-8.24% (P=0.002).
      In both cases, there was a significant increment from M1 and M2 to M3.
      CONCLUSION: It was shown that a single dose of 0.1 mg of rhTSH, given 96 h after 
      the exposure to computed tomography iodinated contrast media, enhances the RAIU
      in nine euthyroid patients 4 h after 123I administration. These results indicate 
      that rhTSH could be useful for avoiding delay in the treatment of patients with
      131I.
FAU - Resende, Monique
AU  - Resende M
AD  - Department of Endocrinology, Faculdade de Medicina, UFRJ, Brazil.
      moniqueres@terra.com.br
FAU - Corbo, Rossana
AU  - Corbo R
FAU - Vaisman, Mario
AU  - Vaisman M
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - England
TA  - Nucl Med Commun
JT  - Nuclear medicine communications
JID - 8201017
RN  - 0 (Contrast Media)
RN  - 0 (Iodides)
RN  - 0 (Iodine Radioisotopes)
RN  - 0 (Recombinant Proteins)
RN  - 9002-71-5 (Thyrotropin)
SB  - IM
MH  - Adult
MH  - Biological Transport/drug effects
MH  - *Contrast Media
MH  - Female
MH  - Humans
MH  - *Iodides
MH  - Iodine Radioisotopes/metabolism
MH  - Male
MH  - Middle Aged
MH  - Recombinant Proteins/*pharmacology
MH  - Thyroid Gland/diagnostic imaging/*drug effects/*metabolism
MH  - Thyrotropin/*pharmacology
MH  - Tomography, X-Ray Computed
MH  - Young Adult
EDAT- 2010/01/21 06:00
MHDA- 2010/07/02 06:00
CRDT- 2010/01/21 06:00
PHST- 2010/01/21 06:00 [entrez]
PHST- 2010/01/21 06:00 [pubmed]
PHST- 2010/07/02 06:00 [medline]
AID - 10.1097/MNM.0b013e3283355c8b [doi]
PST - ppublish
SO  - Nucl Med Commun. 2010 Apr;31(4):315-9. doi: 10.1097/MNM.0b013e3283355c8b.


PMID- 20087172
OWN - NLM
STAT- MEDLINE
DCOM- 20100628
LR  - 20191210
IS  - 1473-5733 (Electronic)
IS  - 0957-5235 (Linking)
VI  - 21
IP  - 3
DP  - 2010 Apr
TI  - Determination of enoxaparin with rotational thrombelastometry using the
      prothrombinase-induced clotting time reagent.
PG  - 256-61
LID - 10.1097/MBC.0b013e328337014c [doi]
AB  - Drug monitoring of low molecular weight heparin is generally not recommended, but
      could be reasonable in critically ill patients, whose risk for bleeding or
      thrombosis shows a high interpatient variability. Anti-Xa assays are not
      available around the clock even in central hospitals, whereas rotational
      thrombelastometry (ROTEM) becomes increasingly used at the bedside.
      Prothrombinase-induced clotting time (PiCT) reagent allows determination of
      factor Xa-inhibition in plasma. The aim of our study was to evaluate enoxaparin
      determination in whole blood with the ROTEM using specific test modifications,
      including PiCT. After ethics committee's approval, citrated whole blood obtained 
      from overall 16 healthy volunteers was incubated with enoxaparin at 16 different 
      anti-Xa concentrations. Main endpoint was the clotting time (CT) in ROTEM
      representing initial activation of clot formation. CT was determined in the new
      PiCT-ROTEM test, in a low-tissue factor-activated modification (LowTF-ROTEM) as
      well as in the commercially available heparin-sensitive ROTEM assays (HEPTEM and 
      INTEM). In the absence of enoxaparin, CT values were 168.6 +/- 6.1 s
      (PiCT-ROTEM), 247.3 +/- 18.6 s (LowTF-ROTEM), and -6.2 +/- 7.9 s (INTEM-HEPTEM). 
      A linear dependency (P < 0.01) between anti-Xa concentration and CT was found for
      PiCT-ROTEM, LowTF-ROTEM, and for INTEM-HEPTEM with correlation coefficients of
      0.93 for PiCT-ROTEM, 0.94 for LowTF-ROTEM, and 0.81 for INTEM-HEPTEM. This
      in-vitro experiment demonstrates a strong correlation between enoxaparin anti-Xa 
      concentrations and specific ROTEM tests. These promising assays should be further
      evaluated for monitoring anticoagulation in high-risk patients in clinical
      studies.
FAU - Schaden, Eva
AU  - Schaden E
AD  - Department of Anesthesiology, General Intensive Care and Pain Management, Medical
      University of Vienna, Vienna, Austria. eva.schaden@meduniwien.ac.at
FAU - Schober, Andreas
AU  - Schober A
FAU - Hacker, Stefan
AU  - Hacker S
FAU - Spiss, Christian
AU  - Spiss C
FAU - Chiari, Astrid
AU  - Chiari A
FAU - Kozek-Langenecker, Sibylle
AU  - Kozek-Langenecker S
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Blood Coagul Fibrinolysis
JT  - Blood coagulation & fibrinolysis : an international journal in haemostasis and
      thrombosis
JID - 9102551
RN  - 0 (Anticoagulants)
RN  - 0 (Enoxaparin)
RN  - 9035-58-9 (Thromboplastin)
SB  - IM
MH  - Adult
MH  - Anticoagulants/*blood
MH  - Blood Coagulation Tests/*methods
MH  - Drug Monitoring/methods
MH  - Enoxaparin/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Thrombelastography/*methods
MH  - Thromboplastin/*metabolism
EDAT- 2010/01/21 06:00
MHDA- 2010/06/29 06:00
CRDT- 2010/01/21 06:00
PHST- 2010/01/21 06:00 [entrez]
PHST- 2010/01/21 06:00 [pubmed]
PHST- 2010/06/29 06:00 [medline]
AID - 10.1097/MBC.0b013e328337014c [doi]
PST - ppublish
SO  - Blood Coagul Fibrinolysis. 2010 Apr;21(3):256-61. doi:
      10.1097/MBC.0b013e328337014c.


PMID- 20085914
OWN - NLM
STAT- MEDLINE
DCOM- 20100423
LR  - 20100209
IS  - 1460-2350 (Electronic)
IS  - 0268-1161 (Linking)
VI  - 25
IP  - 3
DP  - 2010 Mar
TI  - Lifestyle-related factors and access to medically assisted reproduction.
PG  - 578-83
LID - 10.1093/humrep/dep458 [doi]
AB  - Lifestyle is increasingly recognized as an outcome-determining factor in assisted
      reproduction, not only with regard to the cost-effectiveness but also in view of 
      the balance of benefits and risks, including risks related to the welfare of the 
      future child. This document briefly summarizes the evidence concerning the impact
      of three lifestyle-related factors (obesity, tobacco smoking and alcohol
      consumption) on both natural and assisted reproduction (IVF) and discusses the
      implications of this for the practice of medically assisted reproduction in the
      light of relevant ethical principles. The central question is whether and to what
      extent fertility treatment of obese, smoking or drinking patients should be made 
      conditional on prior lifestyle changes.
CN  - ESHRE Task Force on Ethics and Law, including
AD  - Department of Health, Ethics and Society, Research Institutes CAPHRI and GROW,
      Maastricht University, Maastricht, The Netherlands.
FAU - Dondorp, W
AU  - Dondorp W
FAU - de Wert, G
AU  - de Wert G
FAU - Pennings, G
AU  - Pennings G
FAU - Shenfield, F
AU  - Shenfield F
FAU - Devroey, P
AU  - Devroey P
FAU - Tarlatzis, B
AU  - Tarlatzis B
FAU - Barri, P
AU  - Barri P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100118
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
SB  - IM
MH  - Alcohol Drinking/*adverse effects
MH  - Congenital Abnormalities/prevention & control
MH  - Female
MH  - *Health Services Accessibility
MH  - Humans
MH  - Infant, Newborn
MH  - *Life Style
MH  - Obesity/*etiology
MH  - Patient Compliance
MH  - Pregnancy
MH  - Pregnancy Complications/etiology
MH  - Reproduction
MH  - *Reproductive Techniques, Assisted/ethics
MH  - Smoking/*adverse effects
EDAT- 2010/01/21 06:00
MHDA- 2010/04/24 06:00
CRDT- 2010/01/21 06:00
PHST- 2010/01/21 06:00 [entrez]
PHST- 2010/01/21 06:00 [pubmed]
PHST- 2010/04/24 06:00 [medline]
AID - dep458 [pii]
AID - 10.1093/humrep/dep458 [doi]
PST - ppublish
SO  - Hum Reprod. 2010 Mar;25(3):578-83. doi: 10.1093/humrep/dep458. Epub 2010 Jan 18.


PMID- 20085911
OWN - NLM
STAT- MEDLINE
DCOM- 20100423
LR  - 20220331
IS  - 1460-2350 (Electronic)
IS  - 0268-1161 (Linking)
VI  - 25
IP  - 3
DP  - 2010 Mar
TI  - Should non-mosaic Klinefelter syndrome men be labelled as infertile in 2009?
PG  - 588-97
LID - 10.1093/humrep/dep431 [doi]
AB  - BACKGROUND: Klinefelter syndrome is a common genetic condition. Affected
      non-mosaic men are azoospermic and have been labelled as infertile. Despite
      reports that these men can have children using assisted reproduction techniques, 
      it is not common practice in the UK to offer sperm retrieval to these men.
      METHODS: Medline and EMBASE (1980-2009) were searched independently by two
      authors and all studies involving surgical sperm retrieval in non-mosaic
      Klinefelter syndrome were included. The primary outcome was success of surgical
      sperm retrieval and the secondary outcome was live birth rate. RESULTS: The
      overall success rate for sperm retrieval was 44%, with a higher rate of success
      using micro-dissection testicular sperm aspiration (micro-TESE) (55%). This,
      along with ICSI, has led to the birth of 101 children. However, there are no
      known predictors for successful sperm retrieval. Although there are concerns
      about genetic risk to the offspring of non-mosaic Klinefelter patients, this risk
      has not been found to be greater than that of patients with non-obstructive
      azoospermia with normal karyotype. CONCLUSIONS: It is possible for a man with
      non-mosaic Klinefelter to father a child. However, before these techniques are
      offered, some ethical issues need to be explored.
FAU - Fullerton, G
AU  - Fullerton G
AD  - Aberdeen Fertility Centre, Aberdeen Maternity Hospital, Aberdeen AB25 2ZN, UK.
      gailfullerton@doctors.org.uk
FAU - Hamilton, M
AU  - Hamilton M
FAU - Maheshwari, A
AU  - Maheshwari A
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100119
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aneuploidy
MH  - Azoospermia
MH  - Congenital Abnormalities/genetics
MH  - Female
MH  - Humans
MH  - Infertility, Male/*etiology
MH  - Klinefelter Syndrome/*complications
MH  - Male
MH  - Mosaicism
MH  - Pregnancy
MH  - Pregnancy Outcome
MH  - Preimplantation Diagnosis/ethics
MH  - Risk
MH  - Sperm Injections, Intracytoplasmic
MH  - Sperm Retrieval/*ethics
RF  - 94
EDAT- 2010/01/21 06:00
MHDA- 2010/04/24 06:00
CRDT- 2010/01/21 06:00
PHST- 2010/01/21 06:00 [entrez]
PHST- 2010/01/21 06:00 [pubmed]
PHST- 2010/04/24 06:00 [medline]
AID - dep431 [pii]
AID - 10.1093/humrep/dep431 [doi]
PST - ppublish
SO  - Hum Reprod. 2010 Mar;25(3):588-97. doi: 10.1093/humrep/dep431. Epub 2010 Jan 19.


PMID- 20085739
OWN - NLM
STAT- MEDLINE
DCOM- 20100303
LR  - 20211020
IS  - 1875-9777 (Electronic)
IS  - 1875-9777 (Linking)
VI  - 6
IP  - 1
DP  - 2010 Jan 8
TI  - Cloning mice and men: prohibiting the use of iPS cells for human reproductive
      cloning.
PG  - 16-20
LID - 10.1016/j.stem.2009.12.004 [doi]
AB  - The use of iPSCs and tetraploid complementation for human reproductive cloning
      would raise profound ethical objections. Professional standards and laws that ban
      human reproductive cloning by somatic cell nuclear transfer should be revised to 
      also forbid it by other methods, such as iPSCs via tetraploid complementation.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Lo, Bernard
AU  - Lo B
AD  - Program in Medical Ethics, Department of Medicine, The Eli and Edythe Broad
      Center of Regeneration Medicine and Stem Cell Research, University of California,
      San Francisco, CA 94143, USA. bernie@medicine.ucsf.edu
FAU - Parham, Lindsay
AU  - Parham L
FAU - Alvarez-Buylla, Arturo
AU  - Alvarez-Buylla A
FAU - Cedars, Marcelle
AU  - Cedars M
FAU - Conklin, Bruce
AU  - Conklin B
FAU - Fisher, Susan
AU  - Fisher S
FAU - Gates, Elena
AU  - Gates E
FAU - Giudice, Linda
AU  - Giudice L
FAU - Halme, Dina Gould
AU  - Halme DG
FAU - Hershon, William
AU  - Hershon W
FAU - Kriegstein, Arnold
AU  - Kriegstein A
FAU - Kwok, Pui-Yan
AU  - Kwok PY
FAU - Wagner, Richard
AU  - Wagner R
LA  - eng
GR  - R01 NS028478/NS/NINDS NIH HHS/United States
GR  - UL1 RR024131/RR/NCRR NIH HHS/United States
GR  - 1 UL1 RR024131-04/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Cell Stem Cell
JT  - Cell stem cell
JID - 101311472
SB  - IM
MH  - Animals
MH  - *Bioethics
MH  - Cell Differentiation
MH  - Cloning, Organism/*ethics/methods
MH  - Guidelines as Topic
MH  - Humans
MH  - Mice
MH  - Pluripotent Stem Cells/*cytology
PMC - PMC4035242
MID - NIHMS587063
EDAT- 2010/01/21 06:00
MHDA- 2010/03/04 06:00
CRDT- 2010/01/21 06:00
PHST- 2010/01/21 06:00 [entrez]
PHST- 2010/01/21 06:00 [pubmed]
PHST- 2010/03/04 06:00 [medline]
AID - S1934-5909(09)00627-4 [pii]
AID - 10.1016/j.stem.2009.12.004 [doi]
PST - ppublish
SO  - Cell Stem Cell. 2010 Jan 8;6(1):16-20. doi: 10.1016/j.stem.2009.12.004.


PMID- 20085617
OWN - NLM
STAT- MEDLINE
DCOM- 20100721
LR  - 20220330
IS  - 1365-2842 (Electronic)
IS  - 0305-182X (Linking)
VI  - 37
IP  - 4
DP  - 2010 Apr
TI  - Quality of communication and master impressions for the fabrication of cobalt
      chromium removable partial dentures in general dental practice in England,
      Ireland and Wales in 2009.
PG  - 300-5
LID - 10.1111/j.1365-2842.2009.02055.x [doi]
AB  - The aim of this study was to investigate the quality of communication and master 
      impressions for the fabrication of cobalt chromium removable partial dentures
      (RPDs) in general dental practice in England, Ireland and Wales in 2009. Two
      hundred and ten questionnaires were distributed to 21 laboratories throughout
      England, Ireland and Wales. Information was collected regarding the quality of
      written communication and selection of master impression techniques for cobalt
      chromium partial dentures in general dental practice. One hundred and forty-four 
      questionnaires were returned (response rate = 68%). Alginate was the most popular
      impression material being used in 58% of cases (n = 84), while plastic stock
      trays were the most popular impression tray, being used in 31% of cases (n = 44).
      Twenty-four per cent (n = 35) of impressions were not adequately disinfected.
      Opposing casts were provided in 81% of cases (n = 116). Written instructions were
      described as being 'clear' in 31% of cases (n = 44). In 54% of cases (n = 76),
      the technician was asked to design the RPD. Based on the findings of this study, 
      written communication for cobalt chromium RPDs by general dental practitioners is
      inadequate. This finding is in breach of relevant contemporary legal and ethical 
      guidance. There are also concerns in relation to the fabrication process for this
      form of prosthesis, particularly, in relation to consideration of occlusal
      schemes.
FAU - Kilfeather, G P
AU  - Kilfeather GP
AD  - Vocational Dental Trainee, c/o School of Dentistry, Cardiff University, Cardiff, 
      UK.
FAU - Lynch, C D
AU  - Lynch CD
FAU - Sloan, A J
AU  - Sloan AJ
FAU - Youngson, C C
AU  - Youngson CC
LA  - eng
PT  - Journal Article
DEP - 20100117
PL  - England
TA  - J Oral Rehabil
JT  - Journal of oral rehabilitation
JID - 0433604
RN  - 0 (Chromium Alloys)
RN  - 0 (Dental Casting Investment)
RN  - 0 (Dental Impression Materials)
RN  - 0 (Dental Materials)
SB  - IM
MH  - *Chromium Alloys
MH  - *Dental Casting Investment
MH  - Dental Impression Materials
MH  - *Dental Impression Technique
MH  - Dental Materials
MH  - Denture Design
MH  - *Denture, Partial, Removable
MH  - England
MH  - General Practice, Dental
MH  - Humans
MH  - Ireland
MH  - Laboratories, Dental/*statistics & numerical data
MH  - Models, Dental
MH  - Practice Patterns, Dentists'/statistics & numerical data
MH  - Reproducibility of Results
MH  - Wales
EDAT- 2010/01/21 06:00
MHDA- 2010/07/22 06:00
CRDT- 2010/01/21 06:00
PHST- 2010/01/21 06:00 [entrez]
PHST- 2010/01/21 06:00 [pubmed]
PHST- 2010/07/22 06:00 [medline]
AID - JOR2055 [pii]
AID - 10.1111/j.1365-2842.2009.02055.x [doi]
PST - ppublish
SO  - J Oral Rehabil. 2010 Apr;37(4):300-5. doi: 10.1111/j.1365-2842.2009.02055.x. Epub
      2010 Jan 17.


PMID- 20085546
OWN - NLM
STAT- MEDLINE
DCOM- 20100715
LR  - 20220321
IS  - 1399-6576 (Electronic)
IS  - 0001-5172 (Linking)
VI  - 54
IP  - 4
DP  - 2010 Apr
TI  - Femoral nerve block with ropivacaine or bupivacaine in day case anterior crucial 
      ligament reconstruction.
PG  - 414-20
LID - 10.1111/j.1399-6576.2009.02200.x [doi]
AB  - BACKGROUND/OBJECTIVE: Our aim was to evaluate analgesia, motor block and
      pharmacokinetics of ropivacaine 0.2% and 0.75% in a femoral nerve block (FNB) in 
      day case patients for anterior crucial ligament (ACL)-reconstruction compared
      with bupivacaine 0.25% and placebo. METHODS: Following ethics committee approval 
      and informed consent, 280 patients were randomly allocated to four groups for
      single-shot FNB [30 ml ropivacaine 0.2% (group RO2.0), 0.75% (RO7.5), bupivacaine
      0.25% (BU2.5) and NaCl 0.9% (NaCl)]. Analgesia (pain scores, primary outcome) and
      motor block were assessed at 4 h (dismissal) and up to 24 h. Plasma concentration
      was determined up to 240 min thereafter. RESULTS: Pain scores at 4 h were
      significantly higher for NaCl 4 (0-8) (median, range) (vs.) BU2.5 2 (0-8), RO2.0 
      3 (0-9) and RO7.5 2 (0-8) (NS within the LA groups). Patients of the NaCl group
      needed analgesics significantly more often (93%) within 4 h after surgery vs. 16%
      of group RO2.0, 19% of group RO7.5 and 19% of group BU2.5. Motor block was
      significantly increased with all local anesthetics without a significant
      difference within the LA groups 3 (0-5) in RO2.0, 3 (0-5) in RO7.5 and 3 (0-4) in
      BU2.5 vs. 0 (0-3) in group NaCl (median (range); scale from 0=full strength to
      5=complete paralysis). Peak plasma concentrations differed significantly: RO7.5: 
      1.4 +/- 0.4 (0.73-2.6) [microg/ml, mean +/- SD (range)] after 33 +/- 14 (10-40)
      min, RO2.0: 0.6 +/- 0.3 (0.13-1.0) after 22+17 (10-60) and BU2.5: 0.3 +/- 0.16
      (0.05-0.62) at 31 +/- 17 (10-60), respectively. CONCLUSION: FNB for ACL
      reconstruction with ropivacaine or bupivacaine provided better post-operative
      analgesia than placebo without reaching toxic plasma concentrations. Significant 
      motor block was observed after 4 h in all groups including the lowest
      concentration of ropivacaine but occurred even with placebo.
FAU - Wulf, H
AU  - Wulf H
AD  - Department of Anesthesiology and Intensive Care Medicine, Hospital of the
      Philipps University, Marburg, Germany. h.wulf@med.uni-marburg.de
FAU - Lowe, J
AU  - Lowe J
FAU - Gnutzmann, K-H
AU  - Gnutzmann KH
FAU - Steinfeldt, T
AU  - Steinfeldt T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20100118
PL  - England
TA  - Acta Anaesthesiol Scand
JT  - Acta anaesthesiologica Scandinavica
JID - 0370270
RN  - 0 (Amides)
RN  - 0 (Anesthetics, Local)
RN  - 7IO5LYA57N (Ropivacaine)
RN  - Y8335394RO (Bupivacaine)
SB  - IM
MH  - Adult
MH  - Ambulatory Surgical Procedures
MH  - *Amides/pharmacokinetics
MH  - *Anesthetics, Local/pharmacokinetics
MH  - Anterior Cruciate Ligament/*surgery
MH  - *Arthroscopy
MH  - *Bupivacaine/pharmacokinetics
MH  - *Femoral Nerve
MH  - Humans
MH  - Knee/surgery
MH  - Laryngeal Masks
MH  - Nerve Block/*methods
MH  - Pain/prevention & control
MH  - Pain Measurement
MH  - Pain, Postoperative/epidemiology
MH  - Premedication
MH  - *Reconstructive Surgical Procedures
MH  - Ropivacaine
EDAT- 2010/01/21 06:00
MHDA- 2010/07/16 06:00
CRDT- 2010/01/21 06:00
PHST- 2010/01/21 06:00 [entrez]
PHST- 2010/01/21 06:00 [pubmed]
PHST- 2010/07/16 06:00 [medline]
AID - AAS2200 [pii]
AID - 10.1111/j.1399-6576.2009.02200.x [doi]
PST - ppublish
SO  - Acta Anaesthesiol Scand. 2010 Apr;54(4):414-20. doi:
      10.1111/j.1399-6576.2009.02200.x. Epub 2010 Jan 18.


PMID- 20085404
OWN - NLM
STAT- MEDLINE
DCOM- 20100521
LR  - 20100708
IS  - 1939-1854 (Electronic)
IS  - 0021-9010 (Linking)
VI  - 95
IP  - 1
DP  - 2010 Jan
TI  - Bad apples, bad cases, and bad barrels: meta-analytic evidence about sources of
      unethical decisions at work.
PG  - 1-31
LID - 10.1037/a0017103 [doi]
AB  - As corporate scandals proliferate, practitioners and researchers alike need a
      cumulative, quantitative understanding of the antecedents associated with
      unethical decisions in organizations. In this meta-analysis, the authors draw
      from over 30 years of research and multiple literatures to examine individual
      ("bad apple"), moral issue ("bad case"), and organizational environment ("bad
      barrel") antecedents of unethical choice. Findings provide empirical support for 
      several foundational theories and paint a clearer picture of relationships
      characterized by mixed results. Structural equation modeling revealed the
      complexity (multidetermined nature) of unethical choice, as well as a need for
      research that simultaneously examines different sets of antecedents. Moderator
      analyses unexpectedly uncovered better prediction of unethical behavior than of
      intention for several variables. This suggests a need to more strongly consider a
      new "ethical impulse" perspective in addition to the traditional "ethical
      calculus" perspective. Results serve as a data-based foundation and guide for
      future theoretical and empirical development in the domain of behavioral ethics.
CI  - Copyright 2009 APA, all rights reserved.
FAU - Kish-Gephart, Jennifer J
AU  - Kish-Gephart JJ
AD  - Department of Management and Organization, Pennsylvania State University,
      University Park, PA16801, USA. jjg303@psu.edu
FAU - Harrison, David A
AU  - Harrison DA
FAU - Trevino, Linda Klebe
AU  - Trevino LK
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PL  - United States
TA  - J Appl Psychol
JT  - The Journal of applied psychology
JID - 0222526
SB  - IM
EIN - J Appl Psychol. 2010 Jul;95(4):791
MH  - Choice Behavior
MH  - Decision Making, Organizational
MH  - *Ethics, Professional
MH  - Humans
MH  - Intention
MH  - Intuition
MH  - Organizational Culture
MH  - Workplace/*organization & administration/psychology/statistics & numerical data
EDAT- 2010/01/21 06:00
MHDA- 2010/05/22 06:00
CRDT- 2010/01/21 06:00
PHST- 2010/01/21 06:00 [entrez]
PHST- 2010/01/21 06:00 [pubmed]
PHST- 2010/05/22 06:00 [medline]
AID - 2010-00343-001 [pii]
AID - 10.1037/a0017103 [doi]
PST - ppublish
SO  - J Appl Psychol. 2010 Jan;95(1):1-31. doi: 10.1037/a0017103.


PMID- 20085391
OWN - NLM
STAT- MEDLINE
DCOM- 20100318
LR  - 20211020
IS  - 1179-2027 (Electronic)
IS  - 1170-7690 (Linking)
VI  - 28
IP  - 2
DP  - 2010
TI  - Access with evidence development: the US experience.
PG  - 153-62
LID - 10.2165/11531050-000000000-00000 [doi]
AB  - The concept of access with evidence development (AED), also known as 'coverage
      with evidence development' in the Medicare programme, has long been discussed as 
      a policy option for ensuring more appropriate use of new technologies in the US. 
      This article provides a comprehensive overview of more than 10 years of US
      experience with AED, both in the public and private healthcare sectors. Beginning
      with a discussion of the successes of private plans' conditional coverage for
      high-density chemotherapy for autologous bone marrow transplants for metastatic
      breast cancer and Medicare's conditional coverage of lung-volume-reduction
      surgery in the 1990s, the article moves on to describe how Medicare worked to
      codify AED as one of its coverage policy options in the early part of this
      decade. More recent private and public sector initiatives are also discussed,
      including an overview of barriers to implementing AED. Despite the complexity of 
      political, financial and ethical issues faced in implementation, AED is now a
      permanent fixture of US coverage policy. Future initiatives within the Medicare
      programme and with private payers in the US are much more likely to succeed by
      relying upon the simple but consequential principles laid out at a Summit
      convened in Banff, Alberta, Canada in 2009 and presented in another article in
      this issue.
FAU - Mohr, Penny E
AU  - Mohr PE
AD  - Center for Medical Technology Policy, Baltimore, Maryland 21202, USA.
      penny.mohr@cmtpnet.org
FAU - Tunis, Sean R
AU  - Tunis SR
LA  - eng
PT  - Journal Article
PL  - New Zealand
TA  - Pharmacoeconomics
JT  - PharmacoEconomics
JID - 9212404
MH  - Biomedical Technology/economics
MH  - Evidence-Based Medicine
MH  - Health Policy/*economics
MH  - Humans
MH  - *Insurance Coverage
MH  - Medicare/*economics/organization & administration
MH  - Private Sector
MH  - Public Sector
MH  - Reimbursement Mechanisms
MH  - United States
EDAT- 2010/01/21 06:00
MHDA- 2010/03/20 06:00
CRDT- 2010/01/21 06:00
PHST- 2010/01/21 06:00 [entrez]
PHST- 2010/01/21 06:00 [pubmed]
PHST- 2010/03/20 06:00 [medline]
AID - 10.2165/11531050-000000000-00000 [doi]
PST - ppublish
SO  - Pharmacoeconomics. 2010;28(2):153-62. doi: 10.2165/11531050-000000000-00000.


PMID- 20083829
OWN - NLM
STAT- MEDLINE
DCOM- 20100126
LR  - 20220409
IS  - 1539-3704 (Electronic)
IS  - 0003-4819 (Linking)
VI  - 152
IP  - 2
DP  - 2010 Jan 19
TI  - International consensus recommendations on the management of patients with
      nonvariceal upper gastrointestinal bleeding.
PG  - 101-13
LID - 10.7326/0003-4819-152-2-201001190-00009 [doi]
AB  - DESCRIPTION: A multidisciplinary group of 34 experts from 15 countries developed 
      this update and expansion of the recommendations on the management of acute
      nonvariceal upper gastrointestinal bleeding (UGIB) from 2003. METHODS: The
      Appraisal of Guidelines for Research and Evaluation (AGREE) process and
      independent ethics protocols were used. Sources of data included original and
      published systematic reviews; randomized, controlled trials; and abstracts up to 
      October 2008. Quality of evidence and strength of recommendations have been rated
      by using the Grading of Recommendations Assessment, Development, and Evaluation
      (GRADE) criteria. RECOMMENDATIONS: Recommendations emphasize early risk
      stratification, by using validated prognostic scales, and early endoscopy (within
      24 hours). Endoscopic hemostasis remains indicated for high-risk lesions, whereas
      data support attempts to dislodge clots with hemostatic, pharmacologic, or
      combination treatment of the underlying stigmata. Clips or thermocoagulation,
      alone or with epinephrine injection, are effective methods; epinephrine injection
      alone is not recommended. Second-look endoscopy may be useful in selected
      high-risk patients but is not routinely recommended. Preendoscopy proton-pump
      inhibitor (PPI) therapy may downstage the lesion; intravenous high-dose PPI
      therapy after successful endoscopic hemostasis decreases both rebleeding and
      mortality in patients with high-risk stigmata. Although selected patients can be 
      discharged promptly after endoscopy, high-risk patients should be hospitalized
      for at least 72 hours after endoscopic hemostasis. For patients with UGIB who
      require a nonsteroidal anti-inflammatory drug, a PPI with a cyclooxygenase-2
      inhibitor is preferred to reduce rebleeding. Patients with UGIB who require
      secondary cardiovascular prophylaxis should start receiving acetylsalicylic acid 
      (ASA) again as soon as cardiovascular risks outweigh gastrointestinal risks
      (usually within 7 days); ASA plus PPI therapy is preferred over clopidogrel alone
      to reduce rebleeding.
FAU - Barkun, Alan N
AU  - Barkun AN
AD  - Division of Gastroenterology, Montreal General Hospital Site, McGill University
      Health Centre, Montreal, Quebec, Canada.
FAU - Bardou, Marc
AU  - Bardou M
FAU - Kuipers, Ernst J
AU  - Kuipers EJ
FAU - Sung, Joseph
AU  - Sung J
FAU - Hunt, Richard H
AU  - Hunt RH
FAU - Martel, Myriam
AU  - Martel M
FAU - Sinclair, Paul
AU  - Sinclair P
CN  - International Consensus Upper Gastrointestinal Bleeding Conference Group
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Practice Guideline
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ann Intern Med
JT  - Annals of internal medicine
JID - 0372351
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Anticoagulants)
RN  - 0 (Cyclooxygenase 2 Inhibitors)
RN  - 0 (Proton Pump Inhibitors)
RN  - 0 (Vasoconstrictor Agents)
RN  - R16CO5Y76E (Aspirin)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
CIN - Rev Clin Esp. 2010 Sep;210(8):410-1. PMID: 20591426
SPIN- Ann Intern Med. 2010 Jan 19;152(2):I-48. PMID: 20083812
MH  - Acute Disease
MH  - Anti-Inflammatory Agents, Non-Steroidal/therapeutic use
MH  - Anticoagulants/therapeutic use
MH  - Aspirin/therapeutic use
MH  - Blood Transfusion
MH  - Cyclooxygenase 2 Inhibitors/therapeutic use
MH  - Epinephrine/therapeutic use
MH  - Gastrointestinal Hemorrhage/prevention & control/*therapy
MH  - Hemostasis, Endoscopic
MH  - *Hemostatic Techniques
MH  - Humans
MH  - Prognosis
MH  - Proton Pump Inhibitors/therapeutic use
MH  - Risk Assessment
MH  - Secondary Prevention
MH  - Vasoconstrictor Agents/therapeutic use
IR  - Hunt R
FIR - Hunt, Richard
IR  - Barkun AN
FIR - Barkun, Alan N
IR  - Bardou M
FIR - Bardou, Marc
IR  - Kuipers EJ
FIR - Kuipers, Ernst J
IR  - Sung J
FIR - Sung, Joseph
IR  - Agreus L
FIR - Agreus, Lars
IR  - Armstrong D
FIR - Armstrong, David
IR  - Calvet X
FIR - Calvet, Xavier
IR  - Chiba N
FIR - Chiba, Naoki
IR  - Cipolletta L
FIR - Cipolletta, Livio
IR  - Cohen H
FIR - Cohen, Henry
IR  - Enns R
FIR - Enns, Robert
IR  - Ericsson LG
FIR - Ericsson, Lars-Gunnar
IR  - Gralnek I
FIR - Gralnek, Ian
IR  - Jensen D
FIR - Jensen, Dennis
IR  - Kaminishi M
FIR - Kaminishi, Michio
IR  - Kanwal F
FIR - Kanwal, Fasiha
IR  - Laine L
FIR - Laine, Loren
IR  - Lanas A
FIR - Lanas, Angel
IR  - Lau J
FIR - Lau, James
IR  - Leontiadis G
FIR - Leontiadis, Grigoris
IR  - Lundell L
FIR - Lundell, Lars
IR  - Malfertheiner P
FIR - Malfertheiner, Peter
IR  - Marshall J
FIR - Marshall, John
IR  - Martin J
FIR - Martin, Janet
IR  - Metz D
FIR - Metz, David
IR  - Moayyedi P
FIR - Moayyedi, Paul
IR  - Quenot JP
FIR - Quenot, Jean-Pierre
IR  - Rauws E
FIR - Rauws, Erik
IR  - Romagnuolo J
FIR - Romagnuolo, Joseph
IR  - Rostom A
FIR - Rostom, Alaa
IR  - Spiegel B
FIR - Spiegel, Brennan
IR  - Tse F
FIR - Tse, Frances
IR  - Van Leerdam M
FIR - Van Leerdam, Monique
IR  - Van Rensburg C
FIR - Van Rensburg, Christo
IR  - Jones DJ
FIR - Jones, Derek J
IR  - Gardeazabal A
FIR - Gardeazabal, Andres
IR  - Racz I
FIR - Racz, Istvan
IR  - Lavigne P
FIR - Lavigne, Pauline
IR  - Sinclair P
FIR - Sinclair, Paul
EDAT- 2010/01/20 06:00
MHDA- 2010/01/27 06:00
CRDT- 2010/01/20 06:00
PHST- 2010/01/20 06:00 [entrez]
PHST- 2010/01/20 06:00 [pubmed]
PHST- 2010/01/27 06:00 [medline]
AID - 152/2/101 [pii]
AID - 10.7326/0003-4819-152-2-201001190-00009 [doi]
PST - ppublish
SO  - Ann Intern Med. 2010 Jan 19;152(2):101-13. doi:
      10.7326/0003-4819-152-2-201001190-00009.


PMID- 20083744
OWN - NLM
STAT- MEDLINE
DCOM- 20100319
LR  - 20120924
IS  - 1538-3660 (Electronic)
IS  - 1521-2491 (Linking)
VI  - 12
IP  - 1
DP  - 2010 Jan-Feb
TI  - Arguing the ethics of facial transplantation.
PG  - 60-3
LID - 10.1001/archfacial.2009.106 [doi]
AB  - While 7 face transplants have been performed around the world, to date, there
      remains debate regarding the validity of this procedure. We submit that
      performing a facial transplant-in the appropriately selected patient-is
      technically defensible and ethically sound. By outlining the technical and
      ethical boundaries of the debate, responding to the key arguments against the
      procedure, and describing its motivations and potential benefits, we state our
      justification of facial transplantation.
FAU - Alexander, Ashlin J
AU  - Alexander AJ
AD  - Department of Otolaryngology-Head & Neck Surgery, University of Toronto, ON,
      Canada. ashlin.alexander@gmail.com
FAU - Alam, Daniel S
AU  - Alam DS
FAU - Gullane, Patrick J
AU  - Gullane PJ
FAU - Lengele, Benoit G
AU  - Lengele BG
FAU - Adamson, Peter A
AU  - Adamson PA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Arch Facial Plast Surg
JT  - Archives of facial plastic surgery
JID - 100883500
SB  - IM
MH  - Attitude of Health Personnel
MH  - *Ethics, Medical
MH  - Facial Transplantation/*ethics
MH  - Humans
MH  - Psychology
MH  - Quality of Life/psychology
EDAT- 2010/01/20 06:00
MHDA- 2010/03/20 06:00
CRDT- 2010/01/20 06:00
PHST- 2010/01/20 06:00 [entrez]
PHST- 2010/01/20 06:00 [pubmed]
PHST- 2010/03/20 06:00 [medline]
AID - 12/1/60 [pii]
AID - 10.1001/archfacial.2009.106 [doi]
PST - ppublish
SO  - Arch Facial Plast Surg. 2010 Jan-Feb;12(1):60-3. doi:
      10.1001/archfacial.2009.106.


PMID- 20083467
OWN - NLM
STAT- MEDLINE
DCOM- 20100402
LR  - 20191210
IS  - 0030-6002 (Print)
IS  - 0030-6002 (Linking)
VI  - 151
IP  - 5
DP  - 2010 Jan 31
TI  - [Author-overdose. When will we come clean? - asks the medical librarian].
PG  - 184-92
LID - 10.1556/OH.2010.28761 [doi]
AB  - The present study intends to draw attention to the importance of authorship
      ethics. It is necessary since papers these days that have many authors--even
      10-12 authors--become increasingly general. In the first part of this study the
      change of author-number in four journals--JAMA, Nature, Lancet and Science--was
      analyzed based on the main document types--article, editorial material, letter
      and review--from 1975 until 2009. These changes were similar in all journals. The
      number of authors for 'articles' has changed the most significantly, a fourfold
      increase during 34 years. The possible correlation between the expected citations
      and the change of author-number could not be demonstrated based on this analysis.
      The increase in the number of authors may include more abuses. This study
      emphasizes the guideline of the International Committee of Medical Journal
      Editors regarding authorship ethics which could help to reduce the number of
      misconduct cases. The analysis of some foreign and Hungarian biomedical journals 
      reveals that the foreign periodicals try to follow the main guidelines, but only 
      4 Hungarian journals, of the analyzed 16, point out the matter of the authorship 
      ethics. The practical solution for this problem is still in the making.
FAU - Berhidi, Anna
AU  - Berhidi A
AD  - Semmelweis Egyetem, Kozponti Konyvtar, Budapest, Mikszath Kalman ter 5., 1088.
      aberhidi@lib.sote.hu
FAU - Csajbok, Edit
AU  - Csajbok E
FAU - Vasas, Livia
AU  - Vasas L
LA  - hun
PT  - Journal Article
TT  - Szerzoi domping. Mikor ontunk tiszta vizet a poharba? - kerdezi az orvosi
      konyvtaros.
PL  - Hungary
TA  - Orv Hetil
JT  - Orvosi hetilap
JID - 0376412
SB  - IM
CIN - Orv Hetil. 2010 Jul 25;151(30):1236-7. PMID: 20672449
MH  - *Authorship
MH  - *Bibliometrics
MH  - Duplicate Publications as Topic
MH  - *Editorial Policies
MH  - Guidelines as Topic
MH  - Humans
MH  - Hungary
MH  - International Cooperation
MH  - *Journalism, Medical
MH  - Periodicals as Topic/standards/*statistics & numerical data/*trends
MH  - United States
EDAT- 2010/01/20 06:00
MHDA- 2010/04/03 06:00
CRDT- 2010/01/20 06:00
PHST- 2010/01/20 06:00 [entrez]
PHST- 2010/01/20 06:00 [pubmed]
PHST- 2010/04/03 06:00 [medline]
AID - V358151144338X1K [pii]
AID - 10.1556/OH.2010.28761 [doi]
PST - ppublish
SO  - Orv Hetil. 2010 Jan 31;151(5):184-92. doi: 10.1556/OH.2010.28761.


PMID- 20082960
OWN - NLM
STAT- MEDLINE
DCOM- 20100407
LR  - 20100119
IS  - 1879-1131 (Electronic)
IS  - 0738-081X (Linking)
VI  - 28
IP  - 1
DP  - 2010 Jan-Feb
TI  - Ethical issues in health care: facing our responsibilities in 2010.
PG  - 112-4
LID - 10.1016/j.clindermatol.2009.04.005 [doi]
FAU - Franzblau, Michael J
AU  - Franzblau MJ
AD  - Department of Dermatology (emeritus), University of California, Mt. Zion/UCSF
      Medical Center, San Francisco, California 94115, USA. mfranzblau@aol.com
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - Clin Dermatol
JT  - Clinics in dermatology
JID - 8406412
SB  - IM
MH  - Bioethical Issues/*history
MH  - Confidentiality
MH  - Disabled Persons/*history
MH  - Ethics, Medical/*history
MH  - Eugenics/*history
MH  - Europe
MH  - History, 20th Century
MH  - Homicide/ethics/history
MH  - Humans
MH  - National Socialism/history
MH  - Public Health/ethics/*history
MH  - Sterilization, Involuntary/ethics/history
MH  - United States
EDAT- 2010/01/20 06:00
MHDA- 2010/04/08 06:00
CRDT- 2010/01/20 06:00
PHST- 2010/01/20 06:00 [entrez]
PHST- 2010/01/20 06:00 [pubmed]
PHST- 2010/04/08 06:00 [medline]
AID - S0738-081X(09)00091-1 [pii]
AID - 10.1016/j.clindermatol.2009.04.005 [doi]
PST - ppublish
SO  - Clin Dermatol. 2010 Jan-Feb;28(1):112-4. doi: 10.1016/j.clindermatol.2009.04.005.


PMID- 20082797
OWN - NLM
STAT- MEDLINE
DCOM- 20100212
LR  - 20100119
IS  - 1532-7361 (Electronic)
IS  - 0039-6060 (Linking)
VI  - 147
IP  - 1
DP  - 2010 Jan
TI  - Ethics education in surgical residency: past, present, and future.
PG  - 114-9
LID - 10.1016/j.surg.2009.04.011 [doi]
FAU - Grossman, Eric
AU  - Grossman E
AD  - Department of Surgery, University of Chicago, Chicago, IL 60637, USA.
      eric.grossman@uchospitals.edu
FAU - Posner, Mitchell C
AU  - Posner MC
FAU - Angelos, Peter
AU  - Angelos P
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Surgery
JT  - Surgery
JID - 0417347
SB  - IM
MH  - Ethics, Medical/*education
MH  - Internship and Residency/*trends
MH  - Specialties, Surgical/*education/ethics
RF  - 34
EDAT- 2010/01/20 06:00
MHDA- 2010/02/13 06:00
CRDT- 2010/01/20 06:00
PHST- 2008/11/16 00:00 [received]
PHST- 2009/04/06 00:00 [accepted]
PHST- 2010/01/20 06:00 [entrez]
PHST- 2010/01/20 06:00 [pubmed]
PHST- 2010/02/13 06:00 [medline]
AID - S0039-6060(09)00256-6 [pii]
AID - 10.1016/j.surg.2009.04.011 [doi]
PST - ppublish
SO  - Surgery. 2010 Jan;147(1):114-9. doi: 10.1016/j.surg.2009.04.011.


PMID- 20082703
OWN - NLM
STAT- MEDLINE
DCOM- 20100602
LR  - 20211020
IS  - 1747-5341 (Electronic)
IS  - 1747-5341 (Linking)
VI  - 5
DP  - 2010 Jan 18
TI  - Principlism, medical individualism, and health promotion in resource-poor
      countries: can autonomy-based bioethics promote social justice and population
      health?
PG  - 1
LID - 10.1186/1747-5341-5-1 [doi]
AB  - Through its adoption of the biomedical model of disease which promotes medical
      individualism and its reliance on the individual-based anthropology, mainstream
      bioethics has predominantly focused on respect for autonomy in the clinical
      setting and respect for person in the research site, emphasizing
      self-determination and freedom of choice. However, the emphasis on the individual
      has often led to moral vacuum, exaggeration of human agency, and a thin
      (liberal?) conception of justice. Applied to resource-poor countries and
      communities within developed countries, autonomy-based bioethics fails to address
      the root causes of diseases and public health crises with which individuals or
      communities are confronted. A sociological explanation of disease causation is
      needed to broaden principles of biomedical ethics and provides a renewed
      understanding of disease, freedom, medical practice, patient-physician
      relationship, risk and benefit of research and treatment, research priorities,
      and health policy.
FAU - Azetsop, Jacquineau
AU  - Azetsop J
AD  - Faculte de Medecine Teilhard de Chardin, Complexe Medical le Bon Samaritain,
      N'djamena, BP 456, Chad. maishaze@yahoo.com
FAU - Rennie, Stuart
AU  - Rennie S
LA  - eng
PT  - Journal Article
DEP - 20100118
PL  - England
TA  - Philos Ethics Humanit Med
JT  - Philosophy, ethics, and humanities in medicine : PEHM
JID - 101258058
SB  - IM
MH  - *Bioethics
MH  - *Developing Countries
MH  - *Health Promotion
MH  - Humans
MH  - *Personal Autonomy
MH  - *Social Justice
PMC - PMC2828974
EDAT- 2010/01/20 06:00
MHDA- 2010/06/03 06:00
CRDT- 2010/01/20 06:00
PHST- 2009/09/14 00:00 [received]
PHST- 2010/01/18 00:00 [accepted]
PHST- 2010/01/20 06:00 [entrez]
PHST- 2010/01/20 06:00 [pubmed]
PHST- 2010/06/03 06:00 [medline]
AID - 1747-5341-5-1 [pii]
AID - 10.1186/1747-5341-5-1 [doi]
PST - epublish
SO  - Philos Ethics Humanit Med. 2010 Jan 18;5:1. doi: 10.1186/1747-5341-5-1.


PMID- 20082222
OWN - NLM
STAT- MEDLINE
DCOM- 20100610
LR  - 20220317
IS  - 1826-6983 (Electronic)
IS  - 0033-8362 (Linking)
VI  - 115
IP  - 3
DP  - 2010 Apr
TI  - Correlation between breast density in mammography and background enhancement in
      MR mammography.
PG  - 434-41
LID - 10.1007/s11547-010-0513-4 [doi]
AB  - PURPOSE: We aimed to analyse the influence of mammographic breast density on
      background enhancement (BE) at magnetic resonance (MR) mammography in pre- and
      postmenopausal women. In addition, we questioned predictability of
      contrast-enhancement dynamics of normal fibroglandular tissue (NFT) at MR
      mammography according to mammographic breast density. MATERIALS AND METHODS:
      Twenty-six patients (mean age 51.54+/-11.5 years; range 37-79 years) who
      underwent both MR mammography and conventional mammography were included in this 
      retrospective study. Fourteen patients were premenopausal and 12 were
      postmenopausal. The ethics committee of our institution approved the study. The
      mammograms were retrospectively reviewed for overall breast density according to 
      the four-point scale (I-IV) of the Breast Imaging Reporting and Data System
      (BI-RADS) classification. Two radiologists, who were unaware of the clinical
      data, separately assessed the MR mammography images. Images were assessed for
      enhancement kinetic features (enhancement kinetic curve and the early-phase
      enhancement rate) and BE. MR mammography and conventional mammography findings
      were compared according to BI-RADS breast density category and menopausal status.
      RESULTS: Percentage of increased signal intensity values during the first minute 
      did not change according to mammographic breast density, and the mean early-phase
      enhancement rate scores were similar among breast density groups (p=0.942). There
      was no significant difference between pre- and postmenopausal groups. Enhancement
      kinetic features of the different groups based on BI-RADS breast density category
      and menopausal status were similar. There was no correlation between breast
      density and BE in either premenopausal (p=0.211) or in postmenopausal (p=0.735)
      groups. CONCLUSIONS: We determined no correlation between mammographic breast
      density and so-called BE in MR mammography in either premenopausal or
      postmenopausal women. NFT at MR mammography cannot be predicted on the basis of
      mammographic breast density.
FAU - Cubuk, R
AU  - Cubuk R
AD  - Department of Radiology, Maltepe University School of Medicine, Maltepe,
      Istanbul, Turkey. rahmicubuk@yahoo.com
FAU - Tasali, N
AU  - Tasali N
FAU - Narin, B
AU  - Narin B
FAU - Keskiner, F
AU  - Keskiner F
FAU - Celik, L
AU  - Celik L
FAU - Guney, S
AU  - Guney S
LA  - eng
LA  - ita
PT  - Journal Article
DEP - 20100115
PL  - Italy
TA  - Radiol Med
JT  - La Radiologia medica
JID - 0177625
SB  - IM
MH  - Adult
MH  - Aged
MH  - Breast/*pathology
MH  - Breast Neoplasms/diagnostic imaging/*pathology
MH  - Chi-Square Distribution
MH  - Female
MH  - Humans
MH  - Image Enhancement/*methods
MH  - Magnetic Resonance Imaging/*methods
MH  - Mammography
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Statistics, Nonparametric
EDAT- 2010/01/19 06:00
MHDA- 2010/06/11 06:00
CRDT- 2010/01/19 06:00
PHST- 2009/03/24 00:00 [received]
PHST- 2009/05/11 00:00 [accepted]
PHST- 2010/01/19 06:00 [entrez]
PHST- 2010/01/19 06:00 [pubmed]
PHST- 2010/06/11 06:00 [medline]
AID - 10.1007/s11547-010-0513-4 [doi]
PST - ppublish
SO  - Radiol Med. 2010 Apr;115(3):434-41. doi: 10.1007/s11547-010-0513-4. Epub 2010 Jan
      15.


PMID- 20081517
OWN - NLM
STAT- MEDLINE
DCOM- 20100315
LR  - 20220321
IS  - 1528-1159 (Electronic)
IS  - 0362-2436 (Linking)
VI  - 35
IP  - 2
DP  - 2010 Jan 15
TI  - Repeatability, reliability, and concurrent validity of the scoliosis research
      society-22 questionnaire and EuroQol in patients with adolescent idiopathic
      scoliosis.
PG  - 206-9
LID - 10.1097/BRS.0b013e3181b43bdf [doi]
AB  - STUDY DESIGN: Cross-sectional study in patients with adolescent idiopathic
      scoliosis (AIS). OBJECTIVES: To evaluate the repeatability, reliability, internal
      consistency, and concurrent validity (CD) of an adapted Norwegian version of the 
      Scoliosis Research Society 22 questionnaire (SRS-22) and the generic
      health-related quality of life instrument EuroQol (EQ-5D and EQ-VAS). SUMMARY OF 
      BACKGROUND DATA: SRS-22 is widely used for evaluation of health-related quality
      of life in AIS. Its repeatability, which is essential for use in follow-up
      studies, and CD with EuroQol which can be used for cost-utility analysis, has not
      yet been assessed. METHODS: The forward-backward translation of the English
      version of the SRS-22 was performed according to guidelines for cross-cultural
      adaptation of outcome questionnaires. Fifty-seven patients of various ages with
      AIS and deformity severity filled out standardized questionnaires: SRS-22, EQ-5D,
      and EQ-VAS, each twice in a 2-week interval. The study was approved by the
      Regional Ethics Committee for Medical Research in Norway. RESULTS: There were no 
      floor or ceiling effects on the score distributions. The study demonstrated
      moderate internal consistency and high reliability of SRS-22 questionnaire with
      Chronbach alpha and intraclass correlation coefficiency ranging from 0.76 to 0.93
      for the 5 domains. Repeatability was excellent for all SRS-22 domains with
      repeatability coefficients <1. CD with EQ-5D was poor to moderate with Pearson's 
      r ranging from 0.14 to 0.58. However, total scores of the 2 instruments showed
      satisfactory agreement. CONCLUSION: The SRS-22 outcome instrument has
      satisfactory repeatability, but CD with EQ-5D suggests that the disease-specific 
      and the generic questionnaire measure different constructs.
FAU - Adobor, Raphael D
AU  - Adobor RD
AD  - Section for Spine Surgery, and Physical Medicine and Rehabilitation, Department
      of Orthopaedic Surgery, Rikshospitalet University Hospital, Oslo, Norway.
      raphael.adobor@rikshospitalet.no
FAU - Rimeslatten, Silje
AU  - Rimeslatten S
FAU - Keller, Anne
AU  - Keller A
FAU - Brox, Jens Ivar
AU  - Brox JI
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Spine (Phila Pa 1976)
JT  - Spine
JID - 7610646
SB  - IM
MH  - Activities of Daily Living
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Female
MH  - Health Status
MH  - *Health Surveys
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Norway
MH  - Pain Measurement
MH  - Psychometrics/methods
MH  - Quality of Life/psychology
MH  - Reproducibility of Results
MH  - Scoliosis/*psychology
MH  - Societies, Medical
MH  - Surveys and Questionnaires/*standards
EDAT- 2010/01/19 06:00
MHDA- 2010/03/17 06:00
CRDT- 2010/01/19 06:00
PHST- 2010/01/19 06:00 [entrez]
PHST- 2010/01/19 06:00 [pubmed]
PHST- 2010/03/17 06:00 [medline]
AID - 10.1097/BRS.0b013e3181b43bdf [doi]
AID - 00007632-201001150-00014 [pii]
PST - ppublish
SO  - Spine (Phila Pa 1976). 2010 Jan 15;35(2):206-9. doi:
      10.1097/BRS.0b013e3181b43bdf.


PMID- 20079491
OWN - NLM
STAT- MEDLINE
DCOM- 20100324
LR  - 20131121
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 110
IP  - 3
DP  - 2010 Apr
TI  - Lead levels in milk and blood from donors to the Breast Milk Bank in Southern
      Brazil.
PG  - 265-71
LID - 10.1016/j.envres.2009.12.001 [doi]
AB  - Brazilian scientific literature on the adverse effects of lead on the general
      population is still very limited. Lead, a potentially toxic substance, has become
      a public health problem due to its effects, mainly those affecting the central
      nervous system and on the synthesis of heme. The aim of this study is to evaluate
      the level of lead exposure of donors to the Breast Milk Bank in the city of
      Londrina, Parana, by estimating the levels of that metal in milk and blood
      samples. This is a cross-sectional study conducted during the period between
      January and July 2007. All mothers enrolled as donors in the Breast Milk Bank
      were included in this study. A total of 92 volunteers presenting the following
      inclusion criteria were evaluated in the project: volunteers who were healthy,
      without any chronic disease, full-term pregnancy, breastfeeding between the 15th 
      and 210 th day after giving birth, and living in the city of the study. Lead in
      milk and blood was quantified using the inductive coupled plasma mass
      spectroscopy (ICP-MS) technique. All mothers signed a consent form approved by
      the Research Ethics Committee from Londrina State University. The median lead
      concentration in milk samples was 3.0 microg/L, varying from 1.0 to 8.0 microg/L.
      The median of lead in blood was of 2.7 microg/dl, varying from 1.0 to 5.5
      microg/dl. In Spearman correlation analysis, significant but modest correlations 
      could be observed between the concentration of lead in blood and in milk
      (r(s)=0.207, p=0.048), hemoglobin and ALAD activity (r(s)=-0.264, p=0.011), level
      of lead in blood and mother's age (r(s)=0.227, p=0.029). However, for hematocrit 
      and hemoglobin, the correlation was higher (r(s)=0.837, p<0.001). No
      statistically significant associations were found between concentrations of lead 
      in milk and blood and demographic variables studied, obtained through interviews 
      and validated questionnaire. The mean of milk/blood lead ratio was equal to 0.11.
      In general, the values found in the present study are similar to those obtained
      in populations in other countries, and are within background levels.
CI  - (c) 2009 Elsevier Inc. All rights reserved.
FAU - Koyashiki, Gina Ayumi Kobayashi
AU  - Koyashiki GA
AD  - Department of Collective Health, Health Science Center, State University of
      Londrina, Rua Espirito Santo, 1678 apto, 1201 - 86020-420 Londrina, PR, Brazil.
      ginakoyashiki@yahoo.com.br
FAU - Paoliello, Monica Maria Bastos
AU  - Paoliello MM
FAU - Matsuo, Tiemi
AU  - Matsuo T
FAU - de Oliveira, Marcia Maria Benevenuto
AU  - de Oliveira MM
FAU - Mezzaroba, Leda
AU  - Mezzaroba L
FAU - Carvalho, Maria de Fatima
AU  - Carvalho Mde F
FAU - Sakuma, Alice Momoyo
AU  - Sakuma AM
FAU - Turini, Conceicao
AU  - Turini C
FAU - Vannuchi, Marli Terezinha Oliveira
AU  - Vannuchi MT
FAU - Barbosa, Claudia Santiago Dias
AU  - Barbosa CS
LA  - eng
PT  - Journal Article
DEP - 20100115
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 2P299V784P (Lead)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biological Specimen Banks
MH  - Brazil
MH  - Cross-Sectional Studies
MH  - Environmental Exposure/*analysis
MH  - Environmental Monitoring
MH  - Female
MH  - Humans
MH  - Lead/blood/*metabolism
MH  - Maternal Exposure
MH  - Middle Aged
MH  - Milk, Human/*metabolism
MH  - Young Adult
EDAT- 2010/01/19 06:00
MHDA- 2010/03/25 06:00
CRDT- 2010/01/19 06:00
PHST- 2009/01/19 00:00 [received]
PHST- 2009/12/03 00:00 [revised]
PHST- 2009/12/08 00:00 [accepted]
PHST- 2010/01/19 06:00 [entrez]
PHST- 2010/01/19 06:00 [pubmed]
PHST- 2010/03/25 06:00 [medline]
AID - S0013-9351(09)00220-5 [pii]
AID - 10.1016/j.envres.2009.12.001 [doi]
PST - ppublish
SO  - Environ Res. 2010 Apr;110(3):265-71. doi: 10.1016/j.envres.2009.12.001. Epub 2010
      Jan 15.


PMID- 20078879
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20211203
IS  - 1471-2261 (Electronic)
IS  - 1471-2261 (Linking)
VI  - 10
DP  - 2010 Jan 15
TI  - Attenuation of microvascular function in those with cardiovascular disease is
      similar in patients of Indian Asian and European descent.
PG  - 3
LID - 10.1186/1471-2261-10-3 [doi]
AB  - BACKGROUND: Indian Asians are at increased risk of cardiovascular death which
      does not appear to be explained by conventional risk factors. As microvascular
      disease is also more prevalent in Indian Asians, and as it is thought to play a
      role in the development of macrovascular disease, we decided to determine whether
      impaired microcirculation could contribute to this increased cardiovascular risk 
      in Indian Asians. METHODS: Forearm skin laser Doppler fluximetry in response to
      heating and ischaemia was assessed in 83 Europeans (41 with angiographically
      confirmed atherosclerotic coronary artery disease (CAD) and 42 from the general
      population) and 84 Indian Asians (41 with CAD). Explanations for differences in
      microvascular function were sought using multivariate analysis including
      conventional cardiovascular risk factors. RESULTS: Compared to ethnically matched
      control populations both Europeans and Indian Asians with CAD had poorer
      microvascular responses to heating than those without (117(95% CI 105-131) vs.
      142(130-162) arbitrary units, (au) for Europeans and 111(101-122) vs.
      141(131-153)au for Indian Asians) and to ischaemia (44(38-50) vs. 57(49-67)au &
      39(34-45) vs. 49(43-56)au respectively). These differences were not accounted for
      by conventional cardiovascular risk factors. There was no ethnic difference in
      the attenuation of microvascular function associated with CAD. CONCLUSION:
      Patients of European and Indian Asian descent with symptomatic CAD have poorer
      microvascular maximal tissue perfusion and reactive hyperaemia in the skin
      compared to ethnically matched asymptomatic control populations. Despite the
      increased cardiovascular risk in Indian Asians, the attenuation of microvascular 
      function associated with CAD was equivalent in the ethic groups. This suggests
      that in Indian Asians microcirculation does not explain the increased
      susceptibility to CAD.
FAU - Strain, William D
AU  - Strain WD
AD  - Institute of Biomedical and Clinical Science, Peninsula Medical School (Exeter), 
      University of Exeter, UK. david.strain@pms.ac.uk
FAU - Hughes, Alun D
AU  - Hughes AD
FAU - Mayet, Jamil
AU  - Mayet J
FAU - Wright, Andrew R
AU  - Wright AR
FAU - Kooner, Jaspal
AU  - Kooner J
FAU - Chaturvedi, Nish
AU  - Chaturvedi N
FAU - Shore, Angela C
AU  - Shore AC
LA  - eng
GR  - PG/03/144/16262/BHF_/British Heart Foundation/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20100115
PL  - England
TA  - BMC Cardiovasc Disord
JT  - BMC cardiovascular disorders
JID - 100968539
SB  - IM
MH  - Aged
MH  - Asians/*ethnology/genetics
MH  - Blood Flow Velocity/physiology
MH  - Cardiovascular Diseases/*ethnology/genetics/*physiopathology
MH  - Humans
MH  - India/ethnology
MH  - Laser-Doppler Flowmetry/methods
MH  - Male
MH  - Microcirculation/*physiology
MH  - Middle Aged
MH  - Whites/*ethnology/genetics
PMC - PMC2823616
EDAT- 2010/01/19 06:00
MHDA- 2010/09/15 06:00
CRDT- 2010/01/19 06:00
PHST- 2009/09/14 00:00 [received]
PHST- 2010/01/15 00:00 [accepted]
PHST- 2010/01/19 06:00 [entrez]
PHST- 2010/01/19 06:00 [pubmed]
PHST- 2010/09/15 06:00 [medline]
AID - 1471-2261-10-3 [pii]
AID - 10.1186/1471-2261-10-3 [doi]
PST - epublish
SO  - BMC Cardiovasc Disord. 2010 Jan 15;10:3. doi: 10.1186/1471-2261-10-3.


PMID- 20077346
OWN - NLM
STAT- MEDLINE
DCOM- 20100308
LR  - 20100115
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 1
DP  - 2010 Jan
TI  - Insult to injury: ethical confusion in American Heart Association guidelines for 
      cardiopulmonary resuscitation and emergency cardiovascular care.
PG  - 68-70
LID - 10.1080/15265160903460848 [doi]
FAU - Berger, Jeffrey T
AU  - Berger JT
AD  - Winthrop University Hospital, 222 Station Plaza North, Mineola, NY 11501, USA.
      jberger@winthrop.org
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2010 Jan;10(1):61-7. PMID: 20077345
MH  - Advanced Cardiac Life Support/*ethics/standards/trends
MH  - American Heart Association
MH  - Cardiopulmonary Resuscitation/*ethics/standards/trends
MH  - Emergency Medical Services/*ethics
MH  - Humans
MH  - *Practice Guidelines as Topic
MH  - Resuscitation Orders/*ethics
MH  - United States
EDAT- 2010/01/16 06:00
MHDA- 2010/03/10 06:00
CRDT- 2010/01/16 06:00
PHST- 2010/01/16 06:00 [entrez]
PHST- 2010/01/16 06:00 [pubmed]
PHST- 2010/03/10 06:00 [medline]
AID - 918537252 [pii]
AID - 10.1080/15265160903460848 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Jan;10(1):68-70. doi: 10.1080/15265160903460848.


PMID- 20077344
OWN - NLM
STAT- MEDLINE
DCOM- 20100308
LR  - 20111117
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 1
DP  - 2010 Jan
TI  - Ethics or advocacy?
PG  - 59-60
LID - 10.1080/15265160903460962 [doi]
FAU - Sobsey, Dick
AU  - Sobsey D
AD  - University of Alberta, John Dossetor Health Ethics Centre, 5-16 University
      Terrace, Edmonton, Alberta, T6G 2T4 Canada. dick.sobsey@ualberta.ca
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
RN  - 0 (Estrogens)
SB  - IM
CON - Am J Bioeth. 2010 Jan;10(1):30-44. PMID: 20077335
MH  - Body Height/drug effects
MH  - Body Weight/drug effects
MH  - Child
MH  - *Child Advocacy
MH  - Choice Behavior/ethics
MH  - Decision Making/*ethics
MH  - Developmental Disabilities/*complications
MH  - *Disabled Persons
MH  - Estrogens/administration & dosage/adverse effects
MH  - Ethics, Clinical
MH  - Female
MH  - Humans
MH  - Hysterectomy/ethics
MH  - Intellectual Disability/*complications
MH  - Mastectomy/ethics
MH  - *Parents
MH  - Puberty, Precocious/complications/drug therapy/surgery/*therapy
MH  - Sterilization, Involuntary/ethics
EDAT- 2010/01/16 06:00
MHDA- 2010/03/10 06:00
CRDT- 2010/01/16 06:00
PHST- 2010/01/16 06:00 [entrez]
PHST- 2010/01/16 06:00 [pubmed]
PHST- 2010/03/10 06:00 [medline]
AID - 918534431 [pii]
AID - 10.1080/15265160903460962 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Jan;10(1):59-60. doi: 10.1080/15265160903460962.


PMID- 20077335
OWN - NLM
STAT- MEDLINE
DCOM- 20100308
LR  - 20111117
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 1
DP  - 2010 Jan
TI  - Ashley revisited: a response to the critics.
PG  - 30-44
LID - 10.1080/15265160903469336 [doi]
AB  - The case of Ashley X involved a young girl with profound and permanent
      developmental disability who underwent growth attenuation using high-dose
      estrogen, a hysterectomy, and surgical removal of her breast buds. Many
      individuals and groups have been critical of the decisions made by Ashley's
      parents, physicians, and the hospital ethics committee that supported the
      decision. While some of the opposition has been grounded in distorted facts and
      misunderstandings, others have raised important concerns. The purpose of this
      paper is to provide a brief review of the case and the issues it raised, then
      address 25 distinct substantive arguments that have been proposed as reasons that
      Ashley's treatment might be unethical. We conclude that while some important
      concerns have been raised, the weight of these concerns is not sufficient to
      consider the interventions used in Ashley's case to be contrary to her best
      interests, nor are they sufficient to preclude similar use of these interventions
      in the future for carefully selected patients who might also benefit from them.
FAU - Diekema, Douglas S
AU  - Diekema DS
AD  - University of Washington School of Medicine, USA. diek@u.washington.edu
FAU - Fost, Norman
AU  - Fost N
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
RN  - 0 (Estrogens)
SB  - IM
CIN - Am J Bioeth. 2010 Jan;10(1):W4-6. PMID: 20077323
CIN - Am J Bioeth. 2010 Jan;10(1):45-6. PMID: 20077336
CIN - Am J Bioeth. 2010 Jan;10(1):46-8. PMID: 20077337
CIN - Am J Bioeth. 2010 Jan;10(1):48-50. PMID: 20077338
CIN - Am J Bioeth. 2010 Jan;10(1):50-2. PMID: 20077339
CIN - Am J Bioeth. 2010 Jan;10(1):52-4. PMID: 20077340
CIN - Am J Bioeth. 2010 Jan;10(1):54-5. PMID: 20077341
CIN - Am J Bioeth. 2010 Jan;10(1):56. PMID: 20077342
CIN - Am J Bioeth. 2010 Jan;10(1):57-8. PMID: 20077343
CIN - Am J Bioeth. 2010 Jan;10(1):59-60. PMID: 20077344
MH  - *Body Height/drug effects
MH  - Child
MH  - Child Advocacy
MH  - Choice Behavior/ethics
MH  - Decision Making/*ethics
MH  - Developmental Disabilities/*complications
MH  - *Disabled Persons
MH  - Estrogens/*administration & dosage
MH  - *Ethics Committees
MH  - Ethics, Clinical
MH  - Family
MH  - Female
MH  - Hospitals, Pediatric/ethics
MH  - Humans
MH  - Hysterectomy/*ethics
MH  - Intellectual Disability/*complications
MH  - Mastectomy/*ethics
MH  - *Parents
MH  - Personal Autonomy
MH  - Personhood
MH  - Prognosis
MH  - Puberty, Precocious/complications/drug therapy/surgery/*therapy
MH  - *Quality of Life
MH  - Sterilization, Involuntary/ethics
MH  - Uncertainty
MH  - *Wedge Argument
EDAT- 2010/01/16 06:00
MHDA- 2010/03/10 06:00
CRDT- 2010/01/16 06:00
PHST- 2010/01/16 06:00 [entrez]
PHST- 2010/01/16 06:00 [pubmed]
PHST- 2010/03/10 06:00 [medline]
AID - 918536933 [pii]
AID - 10.1080/15265160903469336 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Jan;10(1):30-44. doi: 10.1080/15265160903469336.


PMID- 20077322
OWN - NLM
STAT- MEDLINE
DCOM- 20100308
LR  - 20191210
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 1
DP  - 2010 Jan
TI  - Response to open peer commentaries on "The pitfalls of deducing ethics from
      economics: why the Association of American Medical Colleges is wrong about
      pharmaceutical detailing".
PG  - W1-3
LID - 10.1080/15265160903493088 [doi]
FAU - Huddle, Thomas S
AU  - Huddle TS
AD  - Division of General Internal Medicine, UAB School of Medicine, 1530 3rd Avenue
      South, FOT 720, Birmingham, AL 35294, USA. thuddle@uab.edu
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2010 Jan;10(1):1-8. PMID: 20077321
MH  - *Academic Medical Centers/ethics
MH  - *Advertising/ethics/standards/trends
MH  - *Conflict of Interest/economics
MH  - *Drug Industry/economics/ethics
MH  - *Drug Prescriptions/economics
MH  - Education, Medical, Graduate/economics/ethics
MH  - Ethics, Medical
MH  - Gift Giving/*ethics
MH  - Humans
MH  - Judgment/ethics
MH  - Physicians/economics/ethics
MH  - Practice Patterns, Physicians'/*economics/*ethics
MH  - Public Policy
MH  - Societies, Medical
MH  - Trust
MH  - United States
EDAT- 2010/01/16 06:00
MHDA- 2010/03/10 06:00
CRDT- 2010/01/16 06:00
PHST- 2010/01/16 06:00 [entrez]
PHST- 2010/01/16 06:00 [pubmed]
PHST- 2010/03/10 06:00 [medline]
AID - 918538858 [pii]
AID - 10.1080/15265160903493088 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Jan;10(1):W1-3. doi: 10.1080/15265160903493088.


PMID- 20077321
OWN - NLM
STAT- MEDLINE
DCOM- 20100308
LR  - 20191210
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 10
IP  - 1
DP  - 2010 Jan
TI  - The pitfalls of deducing ethics from behavioral economics: why the Association of
      American Medical Colleges is wrong about pharmaceutical detailing.
PG  - 1-8
LID - 10.1080/15265160903493088 [doi]
AB  - The Association of American Medical Colleges (AAMC) is urging academic medical
      centers to ban pharmaceutical detailing. This policy followed from a
      consideration of behavioral and neuroeconomics research. I argue that this
      research did not warrant the conclusions drawn from it. Pharmaceutical detailing 
      carries risks of cognitive error for physicians, as do other forms of information
      exchange. Physicians may overcome such risks; those determined to do so may
      ethically engage in pharmaceutical detailing. Whether or not they should do so is
      a prudential judgment about which reasonable people may disagree. The AAMC's
      ethical condemnation of detailing is unwarranted and will subvert efforts to
      maintain a realm of physician discretion in clinical work that is increasingly
      threatened in our present practice environment.
FAU - Huddle, Thomas S
AU  - Huddle TS
AD  - Division of General Internal Medicine, University of Alabama School of Medicine, 
      Birmingham, AL 35294, USA. thuddle@uab.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CIN - Am J Bioeth. 2010 Jan;10(1):W1-3. PMID: 20077322
CIN - Am J Bioeth. 2010 Jan;10(1):9-10. PMID: 20077325
CIN - Am J Bioeth. 2010 Jan;10(1):11-3. PMID: 20077326
CIN - Am J Bioeth. 2010 Jan;10(1):13-5. PMID: 20077327
CIN - Am J Bioeth. 2010 Jan;10(1):15-7. PMID: 20077328
CIN - Am J Bioeth. 2010 Jan;10(1):17-9. PMID: 20077329
CIN - Am J Bioeth. 2010 Jan;10(1):19-21. PMID: 20077330
CIN - Am J Bioeth. 2010 Jan;10(1):21-3. PMID: 20077331
CIN - Am J Bioeth. 2010 Jan;10(1):24-5. PMID: 20077332
CIN - Am J Bioeth. 2010 Jan;10(1):26-7. PMID: 20077333
CIN - Am J Bioeth. 2010 Jan;10(1):27-9. PMID: 20077334
MH  - *Academic Medical Centers/ethics
MH  - *Advertising/ethics
MH  - *Conflict of Interest/economics
MH  - *Drug Industry/economics/ethics
MH  - *Drug Prescriptions/economics
MH  - Education, Medical, Graduate/economics/ethics
MH  - Ethics, Medical
MH  - Gift Giving/*ethics
MH  - Humans
MH  - Judgment/ethics
MH  - Physicians/economics/ethics
MH  - Practice Patterns, Physicians'/*economics/*ethics
MH  - Public Policy
MH  - Societies, Medical
MH  - Trust
MH  - United States
EDAT- 2010/01/16 06:00
MHDA- 2010/03/10 06:00
CRDT- 2010/01/16 06:00
PHST- 2010/01/16 06:00 [entrez]
PHST- 2010/01/16 06:00 [pubmed]
PHST- 2010/03/10 06:00 [medline]
AID - 918536695 [pii]
AID - 10.1080/15265160903493088 [doi]
PST - ppublish
SO  - Am J Bioeth. 2010 Jan;10(1):1-8. doi: 10.1080/15265160903493088.


PMID- 20076994
OWN - NLM
STAT- MEDLINE
DCOM- 20100902
LR  - 20211020
IS  - 1573-3599 (Electronic)
IS  - 1059-7700 (Linking)
VI  - 19
IP  - 3
DP  - 2010 Jun
TI  - Publishing a master's thesis: a guide for novice authors.
PG  - 217-27
LID - 10.1007/s10897-009-9276-2 [doi]
AB  - Publication of original research, clinical experiences, and critical reviews of
      literature are vital to the growth of the genetic counseling field, delivery of
      genetic counseling services, and professional development of genetic counselors. 
      Busy clinical schedules, lack of time and funding, and training that emphasizes
      clinical skills over research skills may make it difficult for new genetic
      counselors to turn their thesis projects into publications. This paper summarizes
      and elaborates upon a presentation aimed at de-mystifying the publishing process 
      given at the 2008 National Society of Genetic Counselors Annual Education
      Conference. Specific topics include familiarizing prospective authors,
      particularly genetic counseling students, with the basics of the publication
      process and related ethical considerations. Former students' experiences with
      publishing master's theses also are described in hopes of encouraging new genetic
      counselors to submit for publication papers based on their thesis projects.
FAU - Resta, Robert G
AU  - Resta RG
AD  - Swedish Cancer Institute, Swedish Medical Center, Seattle, WA, USA.
FAU - McCarthy Veach, Patricia
AU  - McCarthy Veach P
FAU - Charles, Sarah
AU  - Charles S
FAU - Vogel, Kristen
AU  - Vogel K
FAU - Blase, Terri
AU  - Blase T
FAU - Palmer, Christina G S
AU  - Palmer CG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100114
PL  - United States
TA  - J Genet Couns
JT  - Journal of genetic counseling
JID - 9206865
SB  - IM
MH  - *Authorship
MH  - Curriculum
MH  - *Education, Graduate
MH  - Ethics, Professional
MH  - *Genetic Counseling
MH  - Humans
MH  - Journalism
MH  - Mentors
MH  - Peer Review, Research
MH  - Periodicals as Topic
MH  - *Publishing
MH  - Research
PMC - PMC2874663
EDAT- 2010/01/16 06:00
MHDA- 2010/09/03 06:00
CRDT- 2010/01/16 06:00
PHST- 2009/01/27 00:00 [received]
PHST- 2009/11/23 00:00 [accepted]
PHST- 2010/01/16 06:00 [entrez]
PHST- 2010/01/16 06:00 [pubmed]
PHST- 2010/09/03 06:00 [medline]
AID - 10.1007/s10897-009-9276-2 [doi]
PST - ppublish
SO  - J Genet Couns. 2010 Jun;19(3):217-27. doi: 10.1007/s10897-009-9276-2. Epub 2010
      Jan 14.


PMID- 20075315
OWN - NLM
STAT- MEDLINE
DCOM- 20100304
LR  - 20211020
IS  - 1541-0048 (Electronic)
IS  - 0090-0036 (Linking)
VI  - 100
IP  - 3
DP  - 2010 Mar
TI  - The California stem cell initiative: persuasion, politics, and public science.
PG  - 446-51
LID - 10.2105/AJPH.2009.168120 [doi]
AB  - The California Institute for Regenerative Medicine (CIRM) was created by a
      California ballot initiative to make stem cell research a constitutional right,
      in response to Bush administration restrictions on stem cell research. The
      initiative created a taxpayer-funded, multibillion-dollar institution, intended
      to advance public health by developing cures and treatments for diabetes, cancer,
      paralysis, and other conditions. The initiative has been highly controversial
      among stakeholders and watchdog groups concerned with organizational
      transparency, accountability, and the ethics of stem cell research. We
      interviewed major stakeholders-both supporters and opponents-and analyzed
      documents and meeting notes. We found that the CIRM has overcome start-up
      challenges, been selectively influenced by criticism, and adhered to its core
      mission.
FAU - Adelson, Joel W
AU  - Adelson JW
AD  - Institute for Health & Aging, University of California, San Francisco CA 94118,
      USA. joel.adelson@ucsf.edu
FAU - Weinberg, Joanna K
AU  - Weinberg JK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20100114
PL  - United States
TA  - Am J Public Health
JT  - American journal of public health
JID - 1254074
SB  - IM
MH  - *Academies and Institutes/ethics/organization & administration
MH  - Attitude to Health
MH  - California
MH  - *Embryo Research/ethics/legislation & jurisprudence
MH  - *Embryonic Stem Cells
MH  - Federal Government
MH  - Financing, Government/ethics/legislation & jurisprudence
MH  - Human Rights/legislation & jurisprudence
MH  - Humans
MH  - National Institutes of Health (U.S.)/ethics/organization & administration
MH  - Organizational Objectives
MH  - *Politics
MH  - Public Health/ethics/legislation & jurisprudence
MH  - *Regenerative Medicine/ethics/organization & administration
MH  - Research Support as Topic
MH  - Surveys and Questionnaires
MH  - Taxes/legislation & jurisprudence
MH  - United States
PMC - PMC2820047
EDAT- 2010/01/16 06:00
MHDA- 2010/03/05 06:00
CRDT- 2010/01/16 06:00
PHST- 2010/01/16 06:00 [entrez]
PHST- 2010/01/16 06:00 [pubmed]
PHST- 2010/03/05 06:00 [medline]
AID - AJPH.2009.168120 [pii]
AID - 10.2105/AJPH.2009.168120 [doi]
PST - ppublish
SO  - Am J Public Health. 2010 Mar;100(3):446-51. doi: 10.2105/AJPH.2009.168120. Epub
      2010 Jan 14.


PMID- 20074879
OWN - NLM
STAT- MEDLINE
DCOM- 20100518
LR  - 20191210
IS  - 1872-6283 (Electronic)
IS  - 0379-0738 (Linking)
VI  - 195
IP  - 1-3
DP  - 2010 Feb 25
TI  - Digital forensic osteology: morphological sexing of skeletal remains using
      volume-rendered cranial CT scans.
PG  - 148-52
LID - 10.1016/j.forsciint.2009.12.010 [doi]
AB  - Because of the increasing lack of recent bone collections, ethical issues
      concerning maceration procedures, and progress in radiological imaging
      techniques, computed tomography (CT) scans offer an alternative to traditional
      anthropological bone collection. The present study examined volume-rendered
      cranial CT (CCT) scans from 50 crania to morphologically evaluate sex
      characteristics. CCT scans were performed and scored by two teams (Teams A and B)
      of two examiners each (2x50=100 examinations) to evaluate the occurrence and/or
      absence of morphological traits. Altogether, 60 of 100 crania (31 Team A+29 Team 
      B) crania were determined to be male, and 40 (19 Team A+21 Team B) were
      determined to be female when using the scoring system adapted from Knussmann.
      These results imply a sex determination accuracy rate of 96%. Only in one case
      was recalculation of weighting factors necessary to determine one additional
      correct classification. As a single parameter, arcus superciliaris evaluation
      permitted the most accurate sex determination (female, 84.2%; male, 85.5%). No
      significant difference in accuracy rates was observed between the two sexes
      (p<0.65, chi(2)=0.39, Fisher's exact test). Interobserver bias rates for both
      teams were very low (kappa=0.83). The present study shows that volume-rendered
      CCT images are suitable for the collection of data concerning morphologic sex
      determination of skulls. Thus, this method may be helpful in both actual forensic
      casework and the systematic reevaluation and improvement of classical
      anthropological methods and their adaptation to changing populations.
CI  - 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Ramsthaler, Frank
AU  - Ramsthaler F
AD  - Center of Legal Medicine, Institute of Forensic Medicine, Goethe University
      Frankfurt, Frankfurt Main, Germany. ramsthaler@em.uni-frankfurt.de
FAU - Kettner, Mattias
AU  - Kettner M
FAU - Gehl, Axel
AU  - Gehl A
FAU - Verhoff, M A
AU  - Verhoff MA
LA  - eng
PT  - Journal Article
PT  - Validation Study
DEP - 20100113
PL  - Ireland
TA  - Forensic Sci Int
JT  - Forensic science international
JID - 7902034
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Forensic Anthropology/methods
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Observer Variation
MH  - Reproducibility of Results
MH  - Sex Determination by Skeleton/*methods
MH  - Skull/*anatomy & histology/*diagnostic imaging
MH  - *Tomography, X-Ray Computed
EDAT- 2010/01/16 06:00
MHDA- 2010/05/19 06:00
CRDT- 2010/01/16 06:00
PHST- 2009/03/02 00:00 [received]
PHST- 2009/11/16 00:00 [revised]
PHST- 2009/12/04 00:00 [accepted]
PHST- 2010/01/16 06:00 [entrez]
PHST- 2010/01/16 06:00 [pubmed]
PHST- 2010/05/19 06:00 [medline]
AID - S0379-0738(09)00489-7 [pii]
AID - 10.1016/j.forsciint.2009.12.010 [doi]
PST - ppublish
SO  - Forensic Sci Int. 2010 Feb 25;195(1-3):148-52. doi:
      10.1016/j.forsciint.2009.12.010. Epub 2010 Jan 13.


PMID- 20074841
OWN - NLM
STAT- MEDLINE
DCOM- 20100329
LR  - 20211018
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 70
IP  - 6
DP  - 2010 Mar
TI  - Moral work in women's narratives of breastfeeding.
PG  - 951-8
LID - 10.1016/j.socscimed.2009.11.023 [doi]
AB  - Women's narratives of their breastfeeding experiences are sites of construction
      and reconstruction of self as they undertake moral work in relation to feeding
      their baby. We engaged Foucault's 'technologies of the self' and his notion of
      ethics (the relationship with self) to examine that moral work (individual
      actions rather than adherence to universal moral codes) in relation to women's
      subjectivity constructed in interviews with 49 women from the UK. Four categories
      of moral work were identified: biographical preservation, biographical repair,
      altruism and political action. We describe each of these and conclude that
      women's embodied experience and sense of self are disciplined within current,
      limited, often punishing discourses by undertaking painful moral work in order to
      maintain or repair their subjective positions. We suggest the development of new 
      subject positions around infant feeding practices.
CI  - Copyright 2009 Elsevier Ltd. All rights reserved.
FAU - Ryan, Kath
AU  - Ryan K
AD  - Bournemouth University, School of Health & Social Care, Royal London House,
      Christchurch Road, Bournemouth, Dorset BH1 3LT, United Kingdom.
      kryan@bournemouth.ac.uk
FAU - Bissell, Paul
AU  - Bissell P
FAU - Alexander, Jo
AU  - Alexander J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100113
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Attitude to Health
MH  - Breast Feeding/*psychology
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant Nutritional Physiological Phenomena
MH  - Interviews as Topic
MH  - Maternal Behavior
MH  - *Morals
MH  - Mother-Child Relations
MH  - Mothers/*psychology
MH  - Narration
MH  - Qualitative Research
MH  - *Self Concept
MH  - United Kingdom
EDAT- 2010/01/16 06:00
MHDA- 2010/03/30 06:00
CRDT- 2010/01/16 06:00
PHST- 2009/01/29 00:00 [received]
PHST- 2009/10/29 00:00 [revised]
PHST- 2009/11/13 00:00 [accepted]
PHST- 2010/01/16 06:00 [entrez]
PHST- 2010/01/16 06:00 [pubmed]
PHST- 2010/03/30 06:00 [medline]
AID - S0277-9536(09)00818-1 [pii]
AID - 10.1016/j.socscimed.2009.11.023 [doi]
PST - ppublish
SO  - Soc Sci Med. 2010 Mar;70(6):951-8. doi: 10.1016/j.socscimed.2009.11.023. Epub
      2010 Jan 13.


PMID- 20073044
OWN - NLM
STAT- MEDLINE
DCOM- 20100514
LR  - 20100222
IS  - 1549-4918 (Electronic)
IS  - 1066-5099 (Linking)
VI  - 28
IP  - 2
DP  - 2010 Feb
TI  - Law, ethics, religion, and clinical translation in the 21st century - a
      discussion with Stephen Bellamy.
PG  - 177-80
LID - 10.1002/stem.304 [doi]
FAU - Bellamy, Stephen
AU  - Bellamy S
LA  - eng
PT  - Interview
PL  - England
TA  - Stem Cells
JT  - Stem cells (Dayton, Ohio)
JID - 9304532
SB  - IM
MH  - Biomedical Research/ethics/legislation & jurisprudence
MH  - *Ethics
MH  - *Jurisprudence
MH  - *Religion
EDAT- 2010/01/15 06:00
MHDA- 2010/05/15 06:00
CRDT- 2010/01/15 06:00
PHST- 2010/01/15 06:00 [entrez]
PHST- 2010/01/15 06:00 [pubmed]
PHST- 2010/05/15 06:00 [medline]
AID - 10.1002/stem.304 [doi]
PST - ppublish
SO  - Stem Cells. 2010 Feb;28(2):177-80. doi: 10.1002/stem.304.


PMID- 20071594
OWN - NLM
STAT- MEDLINE
DCOM- 20110517
LR  - 20100114
IS  - 1545-1097 (Print)
IS  - 1545-1097 (Linking)
VI  - 9
IP  - 1
DP  - 2010 Jan-Feb
TI  - Routine HIV testing in health care settings: the deterrent factors to maximal
      implementation in sub-Saharan Africa.
PG  - 23-9
LID - 10.1177/1545109709356355 [doi]
AB  - The sub-Saharan region of Africa is the most severely affected HIV/AIDS region in
      the world. The population of this region accounts for 67% of all people living
      with HIV/AIDS and 72% of all AIDS-related deaths. As international collaboration 
      makes access to HIV treatment more widely available in this region the need to
      increase the population's awareness of its serostatus becomes greater. The
      incorporation of provider-initiated HIV testing and counseling (routine HIV
      testing model) as part of a routine medical care would not only increase the
      population's serostatus awareness but also lead to a better understanding of HIV 
      prevention and treatment and ultimately, increased utilization of available
      HIV/AIDS prevention programs on a much larger scale. This mini-review summarizes 
      some important regional, sociocultural, economic, legal, and ethical issues that 
      may be deterrent factors to maximal implementation and integration of provider
      initiated HIV testing and counseling as part of routine medical care in the
      sub-Saharan African region.
FAU - Monjok, Emmanuel
AU  - Monjok E
AD  - Institute of Community Health, University of Houston, Texas Medical Center,
      Houston TX 77030, USA. emonjok@uh.edu
FAU - Smesny, Andrea
AU  - Smesny A
FAU - Mgbere, Osaro
AU  - Mgbere O
FAU - Essien, E James
AU  - Essien EJ
LA  - eng
GR  - R01 MH 073361-02/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United States
TA  - J Int Assoc Physicians AIDS Care (Chic)
JT  - Journal of the International Association of Physicians in AIDS Care (Chicago,
      Ill. : 2002)
JID - 101185740
SB  - IM
MH  - AIDS Serodiagnosis/*economics/ethics/legislation & jurisprudence
MH  - Acquired Immunodeficiency Syndrome/*diagnosis/epidemiology/prevention &
      control/transmission
MH  - Africa South of the Sahara/epidemiology
MH  - Counseling/*economics/ethics/legislation & jurisprudence
MH  - Delivery of Health Care/*economics/ethics/legislation & jurisprudence
MH  - Developing Countries
MH  - HIV
MH  - Humans
MH  - Socioeconomic Factors
EDAT- 2010/01/15 06:00
MHDA- 2011/05/18 06:00
CRDT- 2010/01/15 06:00
PHST- 2010/01/15 06:00 [entrez]
PHST- 2010/01/15 06:00 [pubmed]
PHST- 2011/05/18 06:00 [medline]
AID - 9/1/23 [pii]
AID - 10.1177/1545109709356355 [doi]
PST - ppublish
SO  - J Int Assoc Physicians AIDS Care (Chic). 2010 Jan-Feb;9(1):23-9. doi:
      10.1177/1545109709356355.


PMID- 20070896
OWN - NLM
STAT- MEDLINE
DCOM- 20100505
LR  - 20211020
IS  - 1471-2377 (Electronic)
IS  - 1471-2377 (Linking)
VI  - 10
DP  - 2010 Jan 13
TI  - Validation, reproducibility and safety of trans dermal electrical stimulation in 
      chronic pain patients and healthy volunteers.
PG  - 5
LID - 10.1186/1471-2377-10-5 [doi]
AB  - BACKGROUND: Surrogate pain models have been extensively tested in Normal Human
      Volunteers (NHV). There are few studies that examined pain models in chronic pain
      patients. Patients are likely to have altered pain mechanisms. It is of interest 
      to test patient pain responses to selective pain stimuli under controlled
      laboratory conditions. METHODS: The Institutional Ethic Committee approved the
      study. 16 patients with chronic neuropathic radiculopathy and 16 healthy
      volunteers were enrolled to the study after obtaining informed consent. During
      electrical stimulation (150 minutes for volunteers and 75 minutes for patients)
      the following parameters were measured every 10 minutes: Ongoing pain: Visual
      Analogue Scale (VAS) and Numeric Rate Scale (NRS)Allodynia (soft foam
      brush)Hyperalgesia (von Frey monofilament 20 g)Flare. For each endpoint, the area
      under the curve (AUC) was estimated from the start of stimulation to the end of
      stimulation by the trapezoidal rule. The individual AUC values for both periods
      were plotted to show the inter- and intra-subject variability. For each endpoint 
      a mixed effect model was fitted with random effect subject and fixed effect
      visit. The estimate of intra-subject variance and the mean value were then used
      to estimate the sample size of a crossover study required to have a probability
      of 0.80 to detect a 25% change in the mean value. Analysis was done using GenStat
      8th edition. RESULTS: Each endpoint achieved very good reproducibility for
      patients and NHV. Comparison between groups revealed trends towards: Faster
      habituation to painful stimuli in patients. Bigger areas of hyperalgesia in
      patients. Similar area of allodynia and flare (no statistical significance)
      CONCLUSION: The differences demonstrated between patients and NHVs suggest that
      the electrical stimulation device used here may stimulate pathways that are
      affected in the pathological state.
FAU - Lecybyl, Remigiusz
AU  - Lecybyl R
AD  - King's College London, Pain Clinical Research Hub, Denmark Hill Campus, London,
      UK.
FAU - Acosta, Juan
AU  - Acosta J
FAU - Ghoshdastidar, Joydeep
AU  - Ghoshdastidar J
FAU - Stringfellow, Kinga
AU  - Stringfellow K
FAU - Hanna, Magdi
AU  - Hanna M
LA  - eng
PT  - Journal Article
DEP - 20100113
PL  - England
TA  - BMC Neurol
JT  - BMC neurology
JID - 100968555
SB  - IM
MH  - Adult
MH  - Aged
MH  - Area Under Curve
MH  - Chronic Disease
MH  - Habituation, Psychophysiologic
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Models, Statistical
MH  - Pain/*physiopathology
MH  - Pain Measurement
MH  - Physical Stimulation
MH  - Reproducibility of Results
MH  - Time Factors
MH  - Transcutaneous Electric Nerve Stimulation/adverse effects/*methods
MH  - Young Adult
PMC - PMC2823601
EDAT- 2010/01/15 06:00
MHDA- 2010/05/06 06:00
CRDT- 2010/01/15 06:00
PHST- 2009/01/01 00:00 [received]
PHST- 2010/01/13 00:00 [accepted]
PHST- 2010/01/15 06:00 [entrez]
PHST- 2010/01/15 06:00 [pubmed]
PHST- 2010/05/06 06:00 [medline]
AID - 1471-2377-10-5 [pii]
AID - 10.1186/1471-2377-10-5 [doi]
PST - epublish
SO  - BMC Neurol. 2010 Jan 13;10:5. doi: 10.1186/1471-2377-10-5.


PMID- 20070206
OWN - NLM
STAT- MEDLINE
DCOM- 20100625
LR  - 20120425
IS  - 1545-2093 (Electronic)
IS  - 0163-7525 (Linking)
VI  - 31
DP  - 2010
TI  - Family history in public health practice: a genomic tool for disease prevention
      and health promotion.
PG  - 69-87 1 p following 87
LID - 10.1146/annurev.publhealth.012809.103621 [doi]
AB  - Family history is a risk factor for many chronic diseases, including cancer,
      cardiovascular disease, and diabetes. Professional guidelines usually include
      family history to assess health risk, initiate interventions, and motivate
      behavioral changes. The advantages of family history over other genomic tools
      include a lower cost, greater acceptability, and a reflection of shared genetic
      and environmental factors. However, the utility of family history in public
      health has been poorly explored. To establish family history as a public health
      tool, it needs to be evaluated within the ACCE framework (analytical validity;
      clinical validity; clinical utility; and ethical, legal, and social issues).
      Currently, private and public organizations are developing tools to collect
      standardized family histories of many diseases. Their goal is to create family
      history tools that have decision support capabilities and are compatible with
      electronic health records. These advances will help realize the potential of
      family history as a public health tool.
FAU - Valdez, Rodolfo
AU  - Valdez R
AD  - Office of Public Health Genomics, National Center for Chronic Disease Prevention 
      and Health Promotion, Centers for Disease Control and Prevention, Atlanta,
      Georgia 30333, USA. rvaldez@cdc.gov
FAU - Yoon, Paula W
AU  - Yoon PW
FAU - Qureshi, Nadeem
AU  - Qureshi N
FAU - Green, Ridgely Fisk
AU  - Green RF
FAU - Khoury, Muin J
AU  - Khoury MJ
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United States
TA  - Annu Rev Public Health
JT  - Annual review of public health
JID - 8006431
SB  - IM
CIN - Annu Rev Public Health. 2010;31:1-8. PMID: 20001819
MH  - Adult
MH  - Aged
MH  - Cardiovascular Diseases/genetics
MH  - Chronic Disease
MH  - Diabetes Mellitus
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - *Genomics
MH  - *Health Promotion
MH  - Humans
MH  - Male
MH  - Mass Screening/ethics/legislation & jurisprudence
MH  - Medical History Taking
MH  - Middle Aged
MH  - Neoplasms/genetics
MH  - Preventive Medicine
MH  - *Public Health Practice
MH  - Risk Assessment
MH  - Risk Factors
MH  - Sensitivity and Specificity
RF  - 111
EDAT- 2010/01/15 06:00
MHDA- 2010/06/26 06:00
CRDT- 2010/01/15 06:00
PHST- 2010/01/15 06:00 [entrez]
PHST- 2010/01/15 06:00 [pubmed]
PHST- 2010/06/26 06:00 [medline]
AID - 10.1146/annurev.publhealth.012809.103621 [doi]
PST - ppublish
SO  - Annu Rev Public Health. 2010;31:69-87 1 p following 87. doi:
      10.1146/annurev.publhealth.012809.103621.


PMID- 20069936
OWN - NLM
STAT- MEDLINE
DCOM- 20100223
LR  - 20191027
IS  - 0037-8046 (Print)
IS  - 0037-8046 (Linking)
VI  - 55
IP  - 1
DP  - 2010 Jan
TI  - Ethical challenges of military social workers serving in a combat zone.
PG  - 9-18
AB  - Often faced with ethical challenges that may appear extraordinary, military
      social workers comprise a distinctive subgroup of the social work profession.
      From the unique paradigms in which they practice their craft, obvious questions
      about how military social workers address the ethical challenges inherent to
      their wartime mission arise. Using a concept mapping design, this qualitative
      phenomenological study addresses some of the ethical challenges faced by 24
      military social workers who were deployed during Operation Iraqi Freedom and
      Operation Enduring Freedom (combat operations inAfghanistan).The results visually
      display approaches to dealing with the ethical concern of balancing the needs of 
      the client and the needs of the military combat mission. Most participants
      reported that they used clinical judgment rather than moral reasoning when
      dealing with such situations. Other ethical concerns are also explored:
      confidentiality and privacy, conflicts with commanders, relationships and
      boundaries, and diagnosis and treatment. Understanding of these ethical
      challenges is relevant to all social workers as they represent an important
      component of the values,knowledge, and skills germane to the social work
      profession.
FAU - Simmons, Catherine A
AU  - Simmons CA
AD  - College of Social Work, University of Tennessee, Memphis, TN 38163, USA.
      cathysimmons@utk.edu
FAU - Rycraft, Joan R
AU  - Rycraft JR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Soc Work
JT  - Social work
JID - 2984852R
SB  - IM
MH  - Afghan Campaign 2001-
MH  - Combat Disorders/diagnosis/*therapy
MH  - Confidentiality/ethics
MH  - Female
MH  - Humans
MH  - Interprofessional Relations/*ethics
MH  - Iraq War, 2003-2011
MH  - Male
MH  - *Military Personnel
MH  - Models, Theoretical
MH  - Professional-Patient Relations/*ethics
MH  - Social Work/*ethics
MH  - United States
EDAT- 2010/01/15 06:00
MHDA- 2010/02/24 06:00
CRDT- 2010/01/15 06:00
PHST- 2010/01/15 06:00 [entrez]
PHST- 2010/01/15 06:00 [pubmed]
PHST- 2010/02/24 06:00 [medline]
AID - 10.1093/sw/55.1.9 [doi]
PST - ppublish
SO  - Soc Work. 2010 Jan;55(1):9-18. doi: 10.1093/sw/55.1.9.


PMID- 20068372
OWN - NLM
STAT- MEDLINE
DCOM- 20100621
LR  - 20131121
IS  - 1423-0259 (Electronic)
IS  - 0030-3747 (Linking)
VI  - 43
IP  - 4
DP  - 2010
TI  - Evaluation of plasma glutamate levels in normal tension glaucoma.
PG  - 197-200
LID - 10.1159/000272024 [doi]
AB  - AIM/BACKGROUND: Abnormal metabolism of the neurotransmitter glutamate is
      implicated in a number of neurodegenerative conditions. Patients with migraine
      have been shown to have elevated plasma glutamate levels. Migraine is a risk
      factor both in terms of prevalence and progression in normal-tension glaucoma
      (NTG). The aim of this study was to determine whether or not plasma glutamate
      levels are also elevated in NTG. METHODS: Patients were recruited into 2 groups, 
      NTG and control, according to inclusion and exclusion criteria. Patients with
      migraine were excluded from both groups. Fasting blood samples were collected in 
      lithium heparin tubes, transported on ice, and centrifuged for storage at -21
      degrees C. Plasma glutamate levels were measured by an amino acid analyser. Data 
      for each group were compared by applying the Mann-Whitney test. Ethical approval 
      and independent statistical advice for the study was obtained. RESULTS: A total
      of 27 subjects were recruited: 14 to the NTG group and 13 to the control group.
      No significant difference was found between the plasma glutamate levels in the 2 
      groups (p = 0.67). CONCLUSION: Although an association between normal tension and
      migraine is recognized, unlike studies in migraine sufferers, this study finds no
      evidence that patients with NTG have elevated plasma glutamate.
CI  - Copyright 2009 S. Karger AG, Basel.
FAU - Bunting, H
AU  - Bunting H
AD  - Department of Ophthalmology, Singleton Hospital, Sketty, Swansea, UK.
      hjbunting11@doctors.org.uk
FAU - Still, R
AU  - Still R
FAU - Williams, D R
AU  - Williams DR
FAU - Gravenor, M
AU  - Gravenor M
FAU - Austin, M W
AU  - Austin MW
LA  - eng
PT  - Journal Article
DEP - 20091231
PL  - Switzerland
TA  - Ophthalmic Res
JT  - Ophthalmic research
JID - 0267442
RN  - 0RH81L854J (Glutamine)
RN  - 3KX376GY7L (Glutamic Acid)
SB  - IM
MH  - Aged
MH  - Female
MH  - Glutamic Acid/*blood
MH  - Glutamine/blood
MH  - Humans
MH  - Intraocular Pressure
MH  - Low Tension Glaucoma/*blood
MH  - Male
EDAT- 2010/01/14 06:00
MHDA- 2010/06/22 06:00
CRDT- 2010/01/14 06:00
PHST- 2009/04/12 00:00 [received]
PHST- 2009/08/12 00:00 [accepted]
PHST- 2010/01/14 06:00 [entrez]
PHST- 2010/01/14 06:00 [pubmed]
PHST- 2010/06/22 06:00 [medline]
AID - 000272024 [pii]
AID - 10.1159/000272024 [doi]
PST - ppublish
SO  - Ophthalmic Res. 2010;43(4):197-200. doi: 10.1159/000272024. Epub 2009 Dec 31.


PMID- 20067690
OWN - NLM
STAT- MEDLINE
DCOM- 20100326
LR  - 20151119
IS  - 1355-7610 (Print)
IS  - 1355-7610 (Linking)
VI  - 17
IP  - 1
DP  - 2010 Jan
TI  - Areca cessation and dentists in Harrow (North London).
PG  - 38-42
LID - 10.1308/135576110790307609 [doi]
AB  - AIM: To assess dentists' awareness and provision of areca cessation counselling
      to patients in general dental practices in Harrow (North London) in 2007.
      METHODS: In this cross-sectional study, questionnaires with specific questions
      and a space for free comments were sent to all 150 general dentists in the
      Primary Care Trust NHS Harrow area on 1st June 2007. The questionnaires had been 
      piloted and the study was given ethical approval by Harrow Research Ethics
      Committee. Completed questionnaires were assessed to determine dentists'
      provision of areca cessation counselling to dental patients. Free comments were
      assessed for content and meaning. RESULTS: A response rate of 57% (83/150
      dentists) was obtained. Dentists were nearly twice as likely to neglect to
      provide patients with areca cessation counselling (32.5%) than to neglect to
      provide tobacco cessation counselling (16.9%). Dentists' comments revealed a lack
      of awareness and the materials and support needed to counsel patients in areca
      cessation. CONCLUSIONS: The majority of dentists who took part in this study
      require increased training, support and materials to facilitate awareness of
      areca nut use in the community and cessation counselling for patients.
FAU - Nathan, Kathryn A
AU  - Nathan KA
AD  - Gentle Dental, Harrow, UK. kathynathan@mac.com
LA  - eng
PT  - Journal Article
PL  - England
TA  - Prim Dent Care
JT  - Primary dental care : journal of the Faculty of General Dental Practitioners (UK)
JID - 9617339
MH  - Adult
MH  - *Areca
MH  - *Counseling
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - London
MH  - Male
MH  - Middle Aged
MH  - Practice Patterns, Dentists'/*statistics & numerical data
MH  - Substance-Related Disorders/*prevention & control
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2010/01/14 06:00
MHDA- 2010/03/27 06:00
CRDT- 2010/01/14 06:00
PHST- 2010/01/14 06:00 [entrez]
PHST- 2010/01/14 06:00 [pubmed]
PHST- 2010/03/27 06:00 [medline]
AID - 10.1308/135576110790307609 [doi]
PST - ppublish
SO  - Prim Dent Care. 2010 Jan;17(1):38-42. doi: 10.1308/135576110790307609.


PMID- 20067492
OWN - NLM
STAT- MEDLINE
DCOM- 20100927
LR  - 20181201
IS  - 1523-1739 (Electronic)
IS  - 0888-8892 (Linking)
VI  - 24
IP  - 3
DP  - 2010 Jun
TI  - Effectiveness of predator removal for enhancing bird populations.
PG  - 820-9
LID - 10.1111/j.1523-1739.2009.01421.x [doi]
AB  - Predation pressure on vulnerable bird species has made predator control an
      important issue for international nature conservation. Predator removal by
      culling or translocation is controversial, expensive, and time-consuming, and
      results are often temporary. Thus, it is important to assess its effectiveness
      from all available evidence. We used explicit systematic review methodology to
      determine the impact of predator removal on four measurable responses in birds:
      breeding performance (hatching success and fledging success) and population size 
      (breeding and postbreeding). We used meta-analysis to summarize results from 83
      predator removal studies from six continents. We also investigated whether
      characteristics of the prey, predator species, location, and study methodology
      explained heterogeneity in effect sizes. Removing predators increased hatching
      success, fledging success, and breeding populations. Removing all predator
      species achieved a significantly larger increase in breeding population than
      removing only a subset. Postbreeding population size was not improved on islands,
      or overall, but did increase on mainlands. Heterogeneity in effect sizes for the 
      four population parameters was not explained by whether predators were native or 
      introduced; prey were declining, migratory, or game species; or by the study
      methodology. Effect sizes for fledging success were smaller for ground-nesting
      birds than those that nest elsewhere, but the difference was not significant. We 
      conclude that current evidence indicates that predator removal is an effective
      strategy for the conservation of vulnerable bird populations. Nevertheless, the
      ethical and practical problems associated with predator removal may lead managers
      to favor alternative, nonlethal solutions. Research is needed to provide and
      synthesize data to determine whether these are effective management practices for
      future policies on bird conservation.
FAU - Smith, Rebecca K
AU  - Smith RK
AD  - Conservation Science Group, Department of Zoology, University of Cambridge,
      Cambridge, UK. r.k.smith@durham.ac.uk
FAU - Pullin, Andrew S
AU  - Pullin AS
FAU - Stewart, Gavin B
AU  - Stewart GB
FAU - Sutherland, William J
AU  - Sutherland WJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20100111
PL  - United States
TA  - Conserv Biol
JT  - Conservation biology : the journal of the Society for Conservation Biology
JID - 9882301
SB  - IM
MH  - Animals
MH  - *Birds
MH  - Conservation of Natural Resources
MH  - Population Growth
MH  - *Predatory Behavior
RF  - 71
EDAT- 2010/01/14 06:00
MHDA- 2010/09/29 06:00
CRDT- 2010/01/14 06:00
PHST- 2010/01/14 06:00 [entrez]
PHST- 2010/01/14 06:00 [pubmed]
PHST- 2010/09/29 06:00 [medline]
AID - CBI1421 [pii]
AID - 10.1111/j.1523-1739.2009.01421.x [doi]
PST - ppublish
SO  - Conserv Biol. 2010 Jun;24(3):820-9. doi: 10.1111/j.1523-1739.2009.01421.x. Epub
      2010 Jan 11.


PMID- 20067356
OWN - NLM
STAT- MEDLINE
DCOM- 20100311
LR  - 20191210
IS  - 1532-5040 (Electronic)
IS  - 0959-3985 (Linking)
VI  - 26
IP  - 2
DP  - 2010 Feb
TI  - Moral distress in physical therapy practice.
PG  - 69-78
LID - 10.3109/09593980903387878 [doi]
AB  - The purpose of this article is to discuss the theoretical concept of moral
      distress in the context of current physical therapy practice and ethics knowledge
      and differentiate it from emotional distress and burnout. Moral distress, largely
      discussed in nursing, is a theoretical concept that has the potential to
      elucidate the experiences of physical therapists delivering direct care to
      patients in complex health care situations and to contribute to physical therapy 
      ethics knowledge and education. It focuses attention on the role of moral agent
      and the ethical dimensions of practice, offers a basis for dialogue among health 
      professionals, and promotes analysis of the impact of the organizational
      environment on practice. The article concludes by suggesting how an understanding
      of the concept of moral distress might inform existing physical therapy ethical
      decision-making models and future research directions by which the experience of 
      moral distress in physical therapy might be explored.
FAU - Carpenter, Christine
AU  - Carpenter C
AD  - Department of Physiotherapy & Dietetics, Faculty of Health and Life Sciences,
      Coventry University, Coventry, UK. c.carpenter@coventry.ac.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - Physiother Theory Pract
JT  - Physiotherapy theory and practice
JID - 9015520
SB  - IM
MH  - Adaptation, Psychological
MH  - *Attitude of Health Personnel
MH  - Burnout, Professional
MH  - *Clinical Competence
MH  - Conflict, Psychological
MH  - Decision Making
MH  - *Ethics, Professional
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Interdisciplinary Communication
MH  - *Morals
MH  - Patient Care Team
MH  - Patient Rights
MH  - Physical Therapy Specialty/*ethics
MH  - Stress, Psychological/*etiology
MH  - Workplace/psychology
EDAT- 2010/01/14 06:00
MHDA- 2010/03/12 06:00
CRDT- 2010/01/14 06:00
PHST- 2010/01/14 06:00 [entrez]
PHST- 2010/01/14 06:00 [pubmed]
PHST- 2010/03/12 06:00 [medline]
AID - 10.3109/09593980903387878 [doi]
PST - ppublish
SO  - Physiother Theory Pract. 2010 Feb;26(2):69-78. doi: 10.3109/09593980903387878.


PMID- 20065954
OWN - NLM
STAT- MEDLINE
DCOM- 20100302
LR  - 20211020
IS  - 1471-0064 (Electronic)
IS  - 1471-0056 (Linking)
VI  - 11
IP  - 2
DP  - 2010 Feb
TI  - Personalized genomic information: preparing for the future of genetic medicine.
PG  - 161-5
LID - 10.1038/nrg2735 [doi]
AB  - The falling cost of sequencing means that we are rapidly approaching an era in
      which access to personalized genomic information is likely to be widespread.
      Here, four experts with different insights into the field of genomic medicine
      answer questions about the prospects for using this type of information. Their
      responses highlight the diverse range of issues that must be addressed - ranging 
      from scientific to ethical and logistical - to ensure that the potential benefits
      of personal genomic information outweigh the costs to both individuals and
      societies.
FAU - Guttmacher, Alan E
AU  - Guttmacher AE
AD  - National Institute of Child Health and Human Development, 31 Center Drive, Room
      2A03, Bethesda, Maryland 20892-2152, USA. guttmach@mail.nih.gov
FAU - McGuire, Amy L
AU  - McGuire AL
FAU - Ponder, Bruce
AU  - Ponder B
FAU - Stefansson, Kari
AU  - Stefansson K
LA  - eng
PT  - Review
DEP - 20100112
PL  - England
TA  - Nat Rev Genet
JT  - Nature reviews. Genetics
JID - 100962779
SB  - IM
MH  - Genetic Testing
MH  - Genetics, Medical/*trends
MH  - *Genome, Human
MH  - Genomics/*methods
MH  - Humans
MH  - Pharmacogenetics/trends
MH  - Precision Medicine/*ethics/statistics & numerical data
MH  - Risk Assessment
EDAT- 2010/01/13 06:00
MHDA- 2010/03/03 06:00
CRDT- 2010/01/13 06:00
PHST- 2010/01/13 06:00 [entrez]
PHST- 2010/01/13 06:00 [pubmed]
PHST- 2010/03/03 06:00 [medline]
AID - nrg2735 [pii]
AID - 10.1038/nrg2735 [doi]
PST - ppublish
SO  - Nat Rev Genet. 2010 Feb;11(2):161-5. doi: 10.1038/nrg2735. Epub 2010 Jan 12.


PMID- 20065910
OWN - NLM
STAT- MEDLINE
DCOM- 20100308
LR  - 20220321
IS  - 1541-8243 (Electronic)
IS  - 0038-4348 (Linking)
VI  - 103
IP  - 2
DP  - 2010 Feb
TI  - Effect of physician education and patient counseling on inpatient nonsurgical
      percutaneous feeding tube placement rate, indications, and outcome.
PG  - 126-30
LID - 10.1097/SMJ.0b013e3181c9800f [doi]
AB  - BACKGROUND: The decision to place a percutaneous feeding tube (PFT) in patients
      who are at the end of life is multidimensional and often complicated. We assessed
      the effect of physician education and counseling for patients and their
      surrogates on inpatient nonsurgical (endoscopic and radiologic) PFT placement
      rates, indications, complications, and mortality. METHODS: In a pre-paid group
      practice, a geriatrician initiated a program of physician education and
      patient/surrogate counseling on the ethical and nutritional aspects of long-term 
      enteral feeding. We compared rates of nonsurgical PFT placement (excluding those 
      for cancer therapy or gastric decompression), indications, complications, and
      short- and long-term mortality in adult inpatients before (2004) and after (2005)
      the program. RESULTS: In 2004 and 2005, 115 and 60 inpatients underwent PFT
      placement, respectively. The annual number of hospital admissions was similar,
      but the rate of PFT placement declined (0.80% vs. 0.44%, P < 0.0001). The
      indications were cerebrovascular accident (42 [37%] versus 22 [37%]), dementia
      (15 [13%] versus 3 [5%]), other neurological disease (28 [24%] versus 16 [26%]), 
      and miscellaneous disease (30 [26%] versus 19 [32%]); P > 0.05. Severe infectious
      complications occurred in 4 (3%) versus 0 (0%) patients, P > 0.05. Mortality
      (2004 versus 2005) at 30 days (23 [20%] versus 11 [18%]), 1 year (62 [54%] versus
      29 [48%]) and 2 years (72 [63%] versus 31 [52%]) was similar, P > 0.05.
      CONCLUSION: A pilot program of educating referring physicians and counseling
      patients and their surrogates reduced the rate of inpatient PFT placement by
      nearly 50%. Indications, severe complications and short- and long-term mortality 
      remained unchanged.
FAU - Swaminath, Arun
AU  - Swaminath A
AD  - Division of Gastroenterology, Columbia University Presbyterian Hospital, New York
      City, NY 10032, USA. as3576@columbia.edu
FAU - Longstreth, George F
AU  - Longstreth GF
FAU - Runnman, Eva M
AU  - Runnman EM
FAU - Yang, Su-Jau
AU  - Yang SJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - South Med J
JT  - Southern medical journal
JID - 0404522
SB  - IM
MH  - Aged
MH  - *Counseling
MH  - *Education, Medical, Continuing
MH  - Enteral Nutrition/mortality/*statistics & numerical data
MH  - Family
MH  - Female
MH  - Humans
MH  - Male
MH  - Pilot Projects
MH  - Terminal Care
MH  - Treatment Outcome
EDAT- 2010/01/13 06:00
MHDA- 2010/03/10 06:00
CRDT- 2010/01/13 06:00
PHST- 2010/01/13 06:00 [entrez]
PHST- 2010/01/13 06:00 [pubmed]
PHST- 2010/03/10 06:00 [medline]
AID - 10.1097/SMJ.0b013e3181c9800f [doi]
PST - ppublish
SO  - South Med J. 2010 Feb;103(2):126-30. doi: 10.1097/SMJ.0b013e3181c9800f.


PMID- 20064703
OWN - NLM
STAT- MEDLINE
DCOM- 20101230
LR  - 20211020
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Linking)
VI  - 122
IP  - 1-3
DP  - 2010 Sep
TI  - The investigator and the IRB: a survey of depression and schizophrenia
      researchers.
PG  - 206-12
LID - 10.1016/j.schres.2009.12.019 [doi]
AB  - Despite the integral part Institutional Review Boards (IRBs) play in U.S.
      research, research on IRBs is lacking. This is especially true in the area of
      mental health investigator-IRB interactions. It was hypothesized that
      schizophrenia researchers would have a different experience with IRBs as compared
      to depression researchers. This would include longer turn-around time and fewer
      protocols approved on first submission. It was also thought that schizophrenia
      researchers would be more hesitant to submit ethically complex protocols for IRB 
      review. 396 NIH-funded schizophrenia and depression investigators were invited to
      participate in a survey study on IRBs. 108 usable responses were returned, 45 of 
      which were from schizophrenia researchers. Schizophrenia researchers were
      significantly less likely to submit ethically complex protocols for IRB review
      than depression researchers even when controlling for academic rank, years of
      research experience, type of research done, and the need to submit to multiple
      IRBs. However, there was no significant difference between researcher groups in
      IRB review turn-around time or initial approval rates. As a group, respondents
      found IRB submission paperwork burdensome but necessary and were almost evenly
      split as to whether IRB comments were helpful (54.8%) or not (45.2%). Time to
      initial review was 3 weeks or longer for most respondents. 94.4% agreed IRBs
      should enforce subject privacy and 68.2% agreed they should monitor conflict of
      interest, but only 37.% agreed IRBs should review study design. Conclusions are
      that 1. the population studied may have profound impacts on the type of protocols
      submitted to IRBs even within the field of mental health, 2. IRBs may not draw as
      large a distinction between depression and schizophrenia protocols as researchers
      believe, and 3. facilitating IRB review by eliminating evaluation of design may
      be possible if the protocol has already been vetted by a credible funding agency 
      (such as the U.S. National Institutes of Health).
CI  - (c) 2009 Elsevier B.V. All rights reserved.
FAU - Fischer, Bernard A
AU  - Fischer BA
AD  - Maryland Psychiatric Research Center, University of Maryland School of Medicine, 
      55 Wade Avenue, P.O. Box 21247, Baltimore, MD 21228, USA.
      bfischer@mprc.umaryland.edu
FAU - George, Praveen
AU  - George P
LA  - eng
GR  - R25 MH060487/MH/NIMH NIH HHS/United States
GR  - R25 MH060487-10/MH/NIMH NIH HHS/United States
GR  - R25 MH60487/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100112
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - Conflict of Interest
MH  - Data Collection
MH  - *Depressive Disorder/therapy
MH  - *Ethics Committees, Research
MH  - Ethics, Research
MH  - Humans
MH  - National Institutes of Health (U.S.)
MH  - *Research Personnel/psychology
MH  - *Schizophrenia/therapy
MH  - United States
PMC - PMC2895950
MID - NIHMS167723
EDAT- 2010/01/13 06:00
MHDA- 2010/12/31 06:00
CRDT- 2010/01/13 06:00
PHST- 2009/08/24 00:00 [received]
PHST- 2009/12/15 00:00 [revised]
PHST- 2009/12/21 00:00 [accepted]
PHST- 2010/01/13 06:00 [entrez]
PHST- 2010/01/13 06:00 [pubmed]
PHST- 2010/12/31 06:00 [medline]
AID - S0920-9964(09)00610-0 [pii]
AID - 10.1016/j.schres.2009.12.019 [doi]
PST - ppublish
SO  - Schizophr Res. 2010 Sep;122(1-3):206-12. doi: 10.1016/j.schres.2009.12.019. Epub 
      2010 Jan 12.


PMID- 20063430
OWN - NLM
STAT- MEDLINE
DCOM- 20100602
LR  - 20100303
IS  - 1531-8257 (Electronic)
IS  - 0885-3185 (Linking)
VI  - 25
IP  - 3
DP  - 2010 Feb 15
TI  - The treatment of psychogenic movement disorders with suggestion is ethically
      justified.
PG  - 260-4
LID - 10.1002/mds.22911 [doi]
AB  - Recent developments in our understanding of psychogenic movement disorders have
      not yet led to advances in treatment. A potentially beneficial treatment strategy
      is suggestion, the voluntary use by the physicians of techniques that introduce
      into the patient's mind a belief that he or she will be healed. Principalism, the
      dominant school of contemporary medical ethics, holds that the use of suggestion 
      is not ethically justifiable because it undermines patient autonomy and degrades 
      the doctor-patient relationship. However, evidence from a variety of sources
      (neuroimaging, anecdote, expert opinion, randomized controlled trials, and
      meta-analysis) supports the efficacy of suggestion as a treatment for psychogenic
      movement disorders. When issues of choice, consent, deceit, disclosure, and
      decision-making are analyzed from the perspective of an ethics of care, we see
      that suggestion may enhance patient autonomy and does not violate the trust
      between doctors and their patients. I conclude that suggestion is therefore an
      ethically justifiable treatment for patients with psychogenic movement disorders.
CI  - (c) 2009 Movement Disorder Society.
FAU - Shamy, Michel C F
AU  - Shamy MC
AD  - University of Toronto, Division of Neurology, Toronto Western Hospital, Toronto, 
      Ontario, Canada. michel.shamy@utoronto.ca
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Mov Disord
JT  - Movement disorders : official journal of the Movement Disorder Society
JID - 8610688
SB  - IM
MH  - Decision Making
MH  - *Ethics, Medical
MH  - Humans
MH  - Informed Consent
MH  - Movement Disorders/*psychology/*therapy
MH  - Personal Autonomy
MH  - Physician-Patient Relations
MH  - *Suggestion
EDAT- 2010/01/12 06:00
MHDA- 2010/06/03 06:00
CRDT- 2010/01/12 06:00
PHST- 2010/01/12 06:00 [entrez]
PHST- 2010/01/12 06:00 [pubmed]
PHST- 2010/06/03 06:00 [medline]
AID - 10.1002/mds.22911 [doi]
PST - ppublish
SO  - Mov Disord. 2010 Feb 15;25(3):260-4. doi: 10.1002/mds.22911.


PMID- 20063198
OWN - NLM
STAT- MEDLINE
DCOM- 20111130
LR  - 20220410
IS  - 1573-3394 (Electronic)
IS  - 1065-3058 (Linking)
VI  - 18
IP  - 4
DP  - 2010 Dec
TI  - The heart of the matter. About good nursing and telecare.
PG  - 374-88
LID - 10.1007/s10728-009-0140-1 [doi]
AB  - Nurses and ethicists worry that the implementation of care at a distance or
      telecare will impoverish patient care by taking out 'the heart' of the clinical
      work. This means that telecare is feared to induce the neglect of patients, and
      to possibly hinder the development of a personal relation between nurse and
      patient. This study aims to analyse whether these worries are warranted by
      analysing Dutch care practices using telemonitoring in care for chronic patients 
      in the Netherlands. How do clinical practices of nursing change when telecare
      devices are introduced and what this means for notions and norms of good nursing?
      The paper concludes that at this point the practices studied do not warrant the
      fear of negligence and compromised relations. Quite the contrary; in the
      practices studied, telecare lead to more frequent and more specialised contacts
      between nurses and patients. The paper concludes by reflecting on the ethical
      implications of these changes.
FAU - Pols, Jeannette
AU  - Pols J
AD  - Department of General Practice, Section of Medical Ethics, Academic Medical
      Centre (AMC) Amsterdam, Postbox 22700, 1100 DE, Amsterdam, The Netherlands.
      a.j.pols@amc.uva.nl
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Health Care Anal
JT  - Health care analysis : HCA : journal of health philosophy and policy
JID - 9432537
MH  - *Attitude of Health Personnel
MH  - Chronic Disease/nursing
MH  - Empirical Research
MH  - Heart Failure/*nursing
MH  - Humans
MH  - Monitoring, Physiologic/methods
MH  - Netherlands
MH  - Nurse-Patient Relations
MH  - Nurses/psychology
MH  - Nursing Care/ethics/*methods
MH  - *Telemedicine
PMC - PMC2970812
EDAT- 2010/01/12 06:00
MHDA- 2011/12/13 00:00
CRDT- 2010/01/12 06:00
PHST- 2010/01/12 06:00 [entrez]
PHST- 2010/01/12 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/s10728-009-0140-1 [doi]
PST - ppublish
SO  - Health Care Anal. 2010 Dec;18(4):374-88. doi: 10.1007/s10728-009-0140-1.


PMID- 20063128
OWN - NLM
STAT- MEDLINE
DCOM- 20101029
LR  - 20211020
IS  - 1525-1497 (Electronic)
IS  - 0884-8734 (Linking)
VI  - 25
IP  - 3
DP  - 2010 Mar
TI  - Family caregivers, patients and physicians: ethical guidance to optimize
      relationships.
PG  - 255-60
LID - 10.1007/s11606-009-1206-3 [doi]
AB  - Family caregivers play a major role in maximizing the health and quality of life 
      of more than 30 million individuals with acute and chronic illness. Patients
      depend on family caregivers for assistance with daily activities, managing
      complex care, navigating the health care system, and communicating with health
      care professionals. Physical, emotional and financial stress may increase
      caregiver vulnerability to injury and illness. Geographically distant family
      caregivers and health professionals in the role of family caregivers may suffer
      additional burdens. Physician recognition of the value of the caregiver role may 
      contribute to a positive caregiving experience and decrease rates of patient
      hospitalization and institutionalization. However, physicians may face ethical
      challenges in partnering with patients and family caregivers while preserving the
      primacy of the patient-physician relationship. The American College of Physicians
      in conjunction with ten other professional societies offers ethical guidance to
      physicians in developing mutually supportive patient-physician-caregiver
      relationships.
FAU - Mitnick, Sheryl
AU  - Mitnick S
AD  - Center for Ethics and Professionalism, American College of Physicians, 190 North 
      Independence Mall West, Philadelphia, PA 19106-1572, USA. smitnick@acponline.org
FAU - Leffler, Cathy
AU  - Leffler C
FAU - Hood, Virginia L
AU  - Hood VL
CN  - American College of Physicians Ethics, Professionalism and Human Rights Committee
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Gen Intern Med
JT  - Journal of general internal medicine
JID - 8605834
SB  - IM
CIN - J Gen Intern Med. 2010 Jun;25(6):487; author reply 488. PMID: 20300874
MH  - Caregivers/*ethics/standards
MH  - *Health Policy
MH  - Humans
MH  - Patients
MH  - Physician-Patient Relations/*ethics
MH  - Physicians/*ethics/standards
MH  - Professional-Family Relations/*ethics
PMC - PMC2839338
EDAT- 2010/01/12 06:00
MHDA- 2010/10/30 06:00
CRDT- 2010/01/12 06:00
PHST- 2009/03/17 00:00 [received]
PHST- 2009/11/10 00:00 [accepted]
PHST- 2009/08/21 00:00 [revised]
PHST- 2010/01/12 06:00 [entrez]
PHST- 2010/01/12 06:00 [pubmed]
PHST- 2010/10/30 06:00 [medline]
AID - 10.1007/s11606-009-1206-3 [doi]
PST - ppublish
SO  - J Gen Intern Med. 2010 Mar;25(3):255-60. doi: 10.1007/s11606-009-1206-3.


PMID- 20062893
OWN - NLM
STAT- MEDLINE
DCOM- 20100315
LR  - 20181201
IS  - 0379-5284 (Print)
IS  - 0379-5284 (Linking)
VI  - 31
IP  - 1
DP  - 2010 Jan
TI  - Antimicrobial activity of tigecycline against bacterial isolates from intensive
      care units in a teaching hospital in Central Saudi Arabia.
PG  - 18-24
AB  - OBJECTIVE: To test the activity of tigecycline against bacterial isolates
      including multi-drug resistant (MDR) gram negative and gram positive organisms
      from intensive care patients. METHODS: Clinically significant gram positive and
      MDR gram negative isolates from specimens of patients in the intensive care units
      of King Khalid University Hospital (KKUH), Riyadh, Kingdom of Saudi Arbia between
      November 1, 2006 and December 31, 2008 were tested against tigecycline by disc
      diffusion (DD) method. In some isolates, the minimal inhibitory concentration was
      carried out by E-test method. Some of the gram negative isolates, and gram
      positive isolates were tested using both methods. The study was approved by the
      hospital ethics committee. RESULTS: All the 83 gram positive organisms tested by 
      both DD and E-test were susceptible to tigecycline. Two hundred and fifty-four
      MDR gram negative isolates were tested for susceptibility to tigecycline. Of
      these 176 tested by DD, 159 (90%) were susceptible, 6 (3.4%) were resistant, and 
      11 (6.2%) were intermediately susceptible (data are not the same in table 3).
      From the 188 isolates tested by E-test, 140 (74.4%) were susceptible, 35 (18.6%) 
      were resistant, and 13 (6.9%) showed intermediate susceptibility. For comparison 
      between the methods, 109 isolates of the MDR gram negative organisms were tested 
      by both E test and DD. The difference between the 2 methods was not significant. 
      CONCLUSION: Tigecycline was active against gram positive and most MDR gram
      negative isolates from patients in medical and surgical intensive cases in KKUH. 
      There was no significant difference between the DD and E-test methods for
      susceptibility testing of tigecycline against these isolates.
FAU - Somily, Ali M
AU  - Somily AM
AD  - Department of Pathology/Microbiology, College of Medicine & King Saud University,
      King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia.
      ali.somily@gmail.com
FAU - Al-Khattaf, Abdulaziz S
AU  - Al-Khattaf AS
FAU - Kambal, Abdelmageed M
AU  - Kambal AM
LA  - eng
PT  - Journal Article
PL  - Saudi Arabia
TA  - Saudi Med J
JT  - Saudi medical journal
JID - 7909441
RN  - 0 (Anti-Bacterial Agents)
RN  - 70JE2N95KR (Tigecycline)
RN  - FYY3R43WGO (Minocycline)
SB  - IM
MH  - Adult
MH  - Anti-Bacterial Agents/pharmacology/*therapeutic use
MH  - Bacterial Infections/*drug therapy/microbiology
MH  - Child
MH  - Disk Diffusion Antimicrobial Tests
MH  - Drug Resistance, Multiple, Bacterial
MH  - Gram-Negative Bacteria/drug effects/isolation & purification
MH  - Gram-Positive Bacteria/drug effects/isolation & purification
MH  - Hospitals, Teaching
MH  - Humans
MH  - *Intensive Care Units
MH  - Minocycline/*analogs & derivatives/pharmacology/therapeutic use
MH  - Saudi Arabia
MH  - Tigecycline
EDAT- 2010/01/12 06:00
MHDA- 2010/03/17 06:00
CRDT- 2010/01/12 06:00
PHST- 2010/01/12 06:00 [entrez]
PHST- 2010/01/12 06:00 [pubmed]
PHST- 2010/03/17 06:00 [medline]
AID - 20090758' [pii]
PST - ppublish
SO  - Saudi Med J. 2010 Jan;31(1):18-24.


PMID- 20061312
OWN - NLM
STAT- MEDLINE
DCOM- 20100809
LR  - 20211020
IS  - 1465-735X (Electronic)
IS  - 0146-8693 (Linking)
VI  - 35
IP  - 3
DP  - 2010 Apr
TI  - Editorial: exploring ethical issues in peer review for the journal of Pediatric
      Psychology.
PG  - 221-4
LID - 10.1093/jpepsy/jsp131 [doi]
FAU - Palermo, Tonya M
AU  - Palermo TM
LA  - eng
GR  - K24 HD060068/HD/NICHD NIH HHS/United States
GR  - K24 HD060068-01A1/HD/NICHD NIH HHS/United States
PT  - Editorial
DEP - 20100107
PL  - United States
TA  - J Pediatr Psychol
JT  - Journal of pediatric psychology
JID - 7801773
SB  - IM
MH  - *Ethics, Professional
MH  - Humans
MH  - Peer Review/*ethics
MH  - *Psychology, Child
MH  - Publishing/*ethics
PMC - PMC2842098
EDAT- 2010/01/12 06:00
MHDA- 2010/08/10 06:00
CRDT- 2010/01/12 06:00
PHST- 2010/01/12 06:00 [entrez]
PHST- 2010/01/12 06:00 [pubmed]
PHST- 2010/08/10 06:00 [medline]
AID - jsp131 [pii]
AID - 10.1093/jpepsy/jsp131 [doi]
PST - ppublish
SO  - J Pediatr Psychol. 2010 Apr;35(3):221-4. doi: 10.1093/jpepsy/jsp131. Epub 2010
      Jan 7.


PMID- 20061008
OWN - NLM
STAT- MEDLINE
DCOM- 20100409
LR  - 20131121
IS  - 1097-6825 (Electronic)
IS  - 0091-6749 (Linking)
VI  - 125
IP  - 2 Suppl 2
DP  - 2010 Feb
TI  - Embryonic and adult stem cell therapy.
PG  - S336-44
LID - 10.1016/j.jaci.2009.09.032 [doi]
AB  - There are many types of stem cells. All share the characteristics of being able
      to self-renew and to give rise to differentiated progeny. Over the last decades, 
      great excitement has been generated by the prospect of being able to exploit
      these properties for the repair, improvement, and/or replacement of damaged
      organs. However, many hurdles, both scientific and ethical, remain in the path of
      using human embryonic stem cells for tissue-engineering purposes. In this report 
      we review current strategies for isolating, enriching, and, most recently,
      inducing the development of human pluripotent stem cells. In so doing, we discuss
      the scientific and ethical issues associated with this endeavor. Finally,
      progress in the use of stem cells as therapies for type 1 diabetes mellitus,
      congestive heart failure, and various neurologic and immunohematologic disorders,
      and as vehicles for the delivery of gene therapy, is briefly discussed.
CI  - Copyright 2010 American Academy of Allergy, Asthma & Immunology. Published by
      Mosby, Inc. All rights reserved.
FAU - Brignier, Anne C
AU  - Brignier AC
AD  - Division of Hematology/Oncology, Department of Medicine, and Abramson Family
      Cancer Research Institute, University of Pennsylvania School of Medicine,
      Philadelphia, PA 19104, USA. brignier@free.fr
FAU - Gewirtz, Alan M
AU  - Gewirtz AM
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100112
PL  - United States
TA  - J Allergy Clin Immunol
JT  - The Journal of allergy and clinical immunology
JID - 1275002
SB  - IM
MH  - Adult Stem Cells/*transplantation
MH  - Animals
MH  - Cell Differentiation/genetics
MH  - Cell- and Tissue-Based Therapy/*trends
MH  - Embryonic Stem Cells/*transplantation
MH  - Humans
MH  - Regenerative Medicine/ethics/methods/*trends
MH  - Stem Cell Niche
MH  - *Stem Cell Transplantation
MH  - Tissue Engineering
MH  - Transcriptional Activation
RF  - 80
EDAT- 2010/01/12 06:00
MHDA- 2010/04/10 06:00
CRDT- 2010/01/12 06:00
PHST- 2009/07/27 00:00 [received]
PHST- 2009/09/18 00:00 [revised]
PHST- 2009/09/21 00:00 [accepted]
PHST- 2010/01/12 06:00 [entrez]
PHST- 2010/01/12 06:00 [pubmed]
PHST- 2010/04/10 06:00 [medline]
AID - S0091-6749(09)01433-X [pii]
AID - 10.1016/j.jaci.2009.09.032 [doi]
PST - ppublish
SO  - J Allergy Clin Immunol. 2010 Feb;125(2 Suppl 2):S336-44. doi:
      10.1016/j.jaci.2009.09.032. Epub 2010 Jan 12.


PMID- 20060197
OWN - NLM
STAT- MEDLINE
DCOM- 20100603
LR  - 20100201
IS  - 1773-0597 (Electronic)
IS  - 0181-5512 (Linking)
VI  - 33
IP  - 1
DP  - 2010 Jan
TI  - [Cultural management of diagnosis announcement in ophthalmology].
PG  - 40-3
LID - 10.1016/j.jfo.2009.11.002 [doi]
AB  - There are important differences in the way cultures conceive diseases. The
      intercultural approach of diseases can enhance the ability of the medical staff
      to understand the patients' problems within their culture, to communicate medical
      explanations to the patients for better mutual comprehension, to alleviate
      patient's sufferings, to ensure compliance to follow up and treatment. We report 
      the case of a multicultural approach for the announcement of a diagnosis of
      blindness for a baby with multiple diseases, in the course of visual
      electrophysiology clinics. This case shows the different possibilities of
      intercultural approach of diseases, with three levels of implication. At the
      first level we may acquire the knowledge of ethnologic tools to understand
      disease representations, types and causes that can be very different from the
      Western ones, in the patient's community. At the second level we may integrate
      cultural consciousness in the management of clinics. At the third level we may
      proceed to the cultural mediation of diseases. Practicing this intercultural
      approach of the patient develops the ethical part of the therapeutic
      relationship, it also provides the patients and the physicians better comfort,
      and better efficiency for prevention campaigns.
CI  - Copyright (c) 2009 Elsevier Masson SAS. All rights reserved.
FAU - Mancel Salino, E H
AU  - Mancel Salino EH
AD  - Centre Hospitalier Territorial de Nouvelle-Caledonie, Service d'Ophtalmologie, BP
      J5, 98849 Noumea cedex, Nouvelle-Caledonie. e.mancel@cht.nc
LA  - fre
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - Approche culturelle dans l'annonce du diagnostic en ophtalmologie.
DEP - 20100107
PL  - France
TA  - J Fr Ophtalmol
JT  - Journal francais d'ophtalmologie
JID - 7804128
SB  - IM
MH  - *Blindness
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - *Ophthalmology
MH  - *Parents
MH  - *Truth Disclosure
EDAT- 2010/01/12 06:00
MHDA- 2010/06/04 06:00
CRDT- 2010/01/12 06:00
PHST- 2009/07/06 00:00 [received]
PHST- 2009/09/29 00:00 [accepted]
PHST- 2010/01/12 06:00 [entrez]
PHST- 2010/01/12 06:00 [pubmed]
PHST- 2010/06/04 06:00 [medline]
AID - S0181-5512(09)00342-8 [pii]
AID - 10.1016/j.jfo.2009.11.002 [doi]
PST - ppublish
SO  - J Fr Ophtalmol. 2010 Jan;33(1):40-3. doi: 10.1016/j.jfo.2009.11.002. Epub 2010
      Jan 7.


PMID- 20059760
OWN - NLM
STAT- MEDLINE
DCOM- 20101102
LR  - 20110131
IS  - 1423-0410 (Electronic)
IS  - 0042-9007 (Linking)
VI  - 99
IP  - 1
DP  - 2010 Jul 1
TI  - Buffy-coat-derived pooled platelet concentrates and apheresis platelet
      concentrates: which product type should be preferred?
PG  - 1-15
LID - 10.1111/j.1423-0410.2009.01295.x [doi]
AB  - There is an ongoing debate whether platelet concentrates (PCs) prepared from
      either whole-blood donations or by plateletpheresis are superior. Usage of these 
      two product types varies greatly between countries and individual institutions.
      Some use mainly apheresis PCs; others prefer pooled PCs which are produced from
      whole-blood donations. This review summarizes the existing information on these
      product types. In the first part data on quality, efficacy and safety are
      reviewed. It is important to note that the issue cannot be answered just by
      comparing 'the' apheresis platelet concentrate versus 'the' pooled platelet
      concentrate. Other factors which determine the quality of a product, e.g.
      residual leukocyte count, plasma content, additive solution or storage period may
      be even more important. The focus of the debate should be shifted. It is much
      more needed to further improve the overall quality of PCs and to optimize
      treatment of thrombocytopenic patients than to concentrate on a single-edged view
      on just the preparation method. In the second part of this review we compare the 
      product types from the donor's point of view. If PCs which are equally safe and
      effective can be obtained by various methods, ethics and the safety of the
      healthy volunteer donor tips the scales. The decision on the use of a particular 
      product type should take into account all aspects of efficacy, side effects and
      availability of the product as well as the donor's perspective and the commitment
      to maximize the use of the valuable whole-blood donation.
FAU - Schrezenmeier, H
AU  - Schrezenmeier H
AD  - Red Cross Blood Service Baden-Wurttemberg-Hessen, Germany.
      h.schrezenmeier@blutspende.de
FAU - Seifried, E
AU  - Seifried E
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20090104
PL  - England
TA  - Vox Sang
JT  - Vox sanguinis
JID - 0413606
SB  - IM
CIN - Vox Sang. 2010 Oct;99(3):295-6; author reply 297-8. PMID: 20561324
CIN - Vox Sang. 2011 Feb;100(2):256-7; author reply 258-9. PMID: 20825600
MH  - *Blood Donors/ethics
MH  - Blood Platelets/cytology/*physiology
MH  - Humans
MH  - Platelet Activation
MH  - Platelet Transfusion/adverse effects/ethics/methods
MH  - Plateletpheresis/ethics/*methods
EDAT- 2010/01/12 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/01/12 06:00
PHST- 2010/01/12 06:00 [entrez]
PHST- 2010/01/12 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - VOX1295 [pii]
AID - 10.1111/j.1423-0410.2009.01295.x [doi]
PST - ppublish
SO  - Vox Sang. 2010 Jul 1;99(1):1-15. doi: 10.1111/j.1423-0410.2009.01295.x. Epub 2009
      Jan 4.


PMID- 20058104
OWN - NLM
STAT- MEDLINE
DCOM- 20110622
LR  - 20110411
IS  - 1864-6433 (Electronic)
IS  - 0914-7187 (Linking)
VI  - 24
IP  - 2
DP  - 2010 Feb
TI  - The effect of giving detailed information about intravenous radiopharmaceutical
      administration on the anxiety level of patients who request more information.
PG  - 67-76
LID - 10.1007/s12149-009-0329-2 [doi]
AB  - OBJECTIVES: Nuclear medicine procedures use radiopharmaceuticals, which produce
      radiation and potential adverse reactions, albeit at a low rate. It is the
      patient's ethical, legal, and medical right to be informed of the potential side 
      effects of procedures applied to them. Our purpose was to determine the effect of
      providing information about intravenous radiopharmaceutical administration on the
      anxiety level of patients who request more information. MATERIALS AND METHODS:
      This study was completed in two separate Nuclear Medicine Departments. The study 
      included 620 (247 M, 373 F) patients who had been referred for myocardial
      perfusion, bone, dynamic renal, and thyroid scintigraphic examinations. The
      patients were divided into two groups according to whether they requested more
      information or not. Group 1 consisted of 388 patients who wanted to receive more 
      information about the procedure, while Group 2 consisted of 232 patients who did 
      not request additional information. The State-Trait Anxiety Inventory (STAI-S and
      STAI-T) was used to determine a patient's anxiety level. After simple information
      was given, state and trait anxiety levels were measured in both groups. We gave
      detailed information to the patients in Group 1 and then measured state anxiety
      again. Detailed information included an explanation of the radiopharmaceutical
      risk and probable side effects due to the scan procedure. RESULTS: There was no
      statistical difference between Groups 1 and 2 in STAI-T or STAI-S scores after
      simple information was given (p = 0.741 and p = 0.945, respectively). The mean
      value of STAI-S score was increased after the provision of detailed information
      and there was a statistically significant difference between after simple
      information SATI-S and after detailed information STAI-S (p < 0.001). The STAI-S 
      score was increased in 246 patients and decreased in 110 patients after detailed 
      information, while there was no change in 32 patients. After detailed
      information, the greatest increase in STAI-S score was seen in the myocardial
      perfusion scan patients, when evaluating according to scan procedure (p < 0.001).
      However, in the dynamic renal patient group, there was no statistical difference 
      (p = 0.271). CONCLUSIONS: Informed consent including detailed information about
      radiation exposure, the risk factors, and potential adverse reactions of
      intravenous radiopharmaceutical administration increased the patients' anxiety
      level in those who request more information.
FAU - Kaya, Eser
AU  - Kaya E
AD  - Department of Nuclear Medicine, Acibadem Hospital, Melikgazi, Kayseri, Turkey.
      esermd@yahoo.com
FAU - Ciftci, Ismail
AU  - Ciftci I
FAU - Demirel, Reha
AU  - Demirel R
FAU - Cigerci, Yeliz
AU  - Cigerci Y
FAU - Gecici, Omer
AU  - Gecici O
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - Japan
TA  - Ann Nucl Med
JT  - Annals of nuclear medicine
JID - 8913398
RN  - 0 (Radiopharmaceuticals)
SB  - IM
MH  - *Access to Information
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Anxiety/diagnosis
MH  - Demography
MH  - *Disclosure
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Radiopharmaceuticals/*administration & dosage/adverse effects
MH  - Risk
MH  - Young Adult
EDAT- 2010/01/09 06:00
MHDA- 2011/06/23 06:00
CRDT- 2010/01/09 06:00
PHST- 2009/07/28 00:00 [received]
PHST- 2009/08/19 00:00 [accepted]
PHST- 2010/01/09 06:00 [entrez]
PHST- 2010/01/09 06:00 [pubmed]
PHST- 2011/06/23 06:00 [medline]
AID - 10.1007/s12149-009-0329-2 [doi]
PST - ppublish
SO  - Ann Nucl Med. 2010 Feb;24(2):67-76. doi: 10.1007/s12149-009-0329-2.


PMID- 20057987
OWN - NLM
STAT- MEDLINE
DCOM- 20100419
LR  - 20211020
IS  - 1433-0563 (Electronic)
IS  - 0340-2592 (Linking)
VI  - 49
IP  - 1
DP  - 2010 Jan
TI  - [Testosterone and psyche].
PG  - 43-6
LID - 10.1007/s00120-009-2197-8 [doi]
AB  - Testosterone, like other steroid hormones, crosses the blood-brain barrier, and
      the androgen receptor is present in most parts of the human brain. Therefore,
      testosterone has many effects on the psyche, mainly in men but also in women.
      Most often discussed is its influence on sexuality, especially on desire and
      sexual fantasies, spontaneous nighttime erections, sexual activity, and the
      number of orgasms and ejaculations. Mood and energy are also testosterone
      related. Testosterone deficiency in male patients can lead to depressive
      disorders. In the past, elevated testosterone levels were seen as responsible for
      strongly aggressive behaviour. Some cognitive functions (spatial and mathematical
      sense, verbal skills) are, at least to a certain point, testosterone related. Due
      to the extremely complex functioning of the human brain, a scientifically exact
      statement regarding the true relationship between testosterone and human
      behaviour is not possible. On the one hand, the cause is definitively
      multifactorial, but on the other, testosterone is metabolised in the brain, and
      the metabolites act by themselves. Furthermore, a bidirectional relationship
      exists between hormones and human behaviour: Human behaviour is influenced by
      hormones, and human behaviour also has a direct influence on the levels of many
      hormones in the human body. Finally, much data in this field are derived from
      animal studies; studies on humans cannot be conducted because of ethical reasons 
      or scientific and technical problems.
FAU - Leiber, C
AU  - Leiber C
AD  - Abteilung Urologie, Chirurgische Klinik, Universitatsklinikum Freiburg,
      Hugstetter Strasse 55, 79106 Freiburg im Breisgau.
      christian.leiber@uniklinik-freiburg.de
FAU - Wetterauer, U
AU  - Wetterauer U
FAU - Berner, M
AU  - Berner M
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Testosteron und Psyche.
PL  - Germany
TA  - Urologe A
JT  - Der Urologe. Ausg. A
JID - 1304110
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - *Emotions
MH  - Female
MH  - Humans
MH  - Hypogonadism/*metabolism/*psychology
MH  - Male
MH  - *Models, Neurological
MH  - *Models, Psychological
MH  - Sexuality/*psychology
MH  - Testosterone/*metabolism
EDAT- 2010/01/09 06:00
MHDA- 2010/04/20 06:00
CRDT- 2010/01/09 06:00
PHST- 2010/01/09 06:00 [entrez]
PHST- 2010/01/09 06:00 [pubmed]
PHST- 2010/04/20 06:00 [medline]
AID - 10.1007/s00120-009-2197-8 [doi]
PST - ppublish
SO  - Urologe A. 2010 Jan;49(1):43-6. doi: 10.1007/s00120-009-2197-8.


PMID- 20056785
OWN - NLM
STAT- MEDLINE
DCOM- 20100506
LR  - 20151119
IS  - 1651-1905 (Electronic)
IS  - 1403-4948 (Linking)
VI  - 38
IP  - 3
DP  - 2010 May
TI  - How are homeless people treated in the healthcare system and other societal
      institutions? Study of their experiences and trust.
PG  - 225-31
LID - 10.1177/1403494809357102 [doi]
AB  - AIMS: To elucidate the perceived treatment that the homeless have received from
      the healthcare and other societal organisations and to present homeless persons' 
      trust in the healthcare system and suggestions of necessary changes for improving
      it. METHODS: Homeless individuals in special houses and institutions in the
      County of Stockholm were asked to answer a short version of a public health
      survey, including added questions about how they experienced the healthcare
      providers' attitudes towards them and how much trust they had in the healthcare
      system. A total of 155 homeless persons (123 male and 32 female) were
      interviewed. RESULTS: Three-quarters of the participants stated that they had
      fairly or very high trust in healthcare services and also felt that they had been
      fairly or very well treated. Fewer females than males reported being treated well
      and they declared a lower degree of trust in the healthcare system. The homeless 
      suggest that extra resources be set aside to organise their healthcare, including
      a higher level of knowledge of the medical problems prevailing in the group.
      Those who felt badly treated also asked for less neglect and disrespect from the 
      healthcare staff. CONCLUSIONS: Even though a majority experience that they are
      being well treated within the healthcare system, the study also indicated
      disadvantages in the treatment of homeless persons in Sweden. The study also
      reveals an imbalance between the official ethical framework in Sweden and of the 
      specific moral of some individual healthcare providers. One way to facilitate
      their entry into the healthcare system might be to create special surgeries for
      the homeless.
FAU - Irestig, Robert
AU  - Irestig R
AD  - Department of Community Medicine, Karolinska University Hospital, Stockholm,
      Sweden.
FAU - Burstrom, Kristina
AU  - Burstrom K
FAU - Wessel, Maja
AU  - Wessel M
FAU - Lynoe, Niels
AU  - Lynoe N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100107
PL  - Sweden
TA  - Scand J Public Health
JT  - Scandinavian journal of public health
JID - 100883503
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Attitude of Health Personnel
MH  - *Delivery of Health Care
MH  - Female
MH  - Health Services Accessibility
MH  - Healthcare Disparities
MH  - *Homeless Persons/psychology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Professional-Patient Relations
MH  - Social Work
MH  - Surveys and Questionnaires
MH  - Sweden
MH  - Trust
MH  - Young Adult
EDAT- 2010/01/09 06:00
MHDA- 2010/05/07 06:00
CRDT- 2010/01/09 06:00
PHST- 2010/01/09 06:00 [entrez]
PHST- 2010/01/09 06:00 [pubmed]
PHST- 2010/05/07 06:00 [medline]
AID - 1403494809357102 [pii]
AID - 10.1177/1403494809357102 [doi]
PST - ppublish
SO  - Scand J Public Health. 2010 May;38(3):225-31. doi: 10.1177/1403494809357102. Epub
      2010 Jan 7.


PMID- 20056208
OWN - NLM
STAT- MEDLINE
DCOM- 20100617
LR  - 20161125
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 94
IP  - 1
DP  - 2010 Jun
TI  - Cross-border reproductive care: quality and safety challenges for the regulator.
PG  - e20-2
LID - 10.1016/j.fertnstert.2009.11.005 [doi]
AB  - Cross-border reproductive care (CBRC) is increasing and poses legal, ethical, and
      moral challenges, not least for the organizations that regulate IVF. Fertility
      treatment in the U.K. is regulated by the Human Fertilisation and Embryology
      Authority which has focused on providing comprehensive information for people
      seeking CBRC, the standards of quality and safety they should expect, and issues 
      of donor anonymity, surrogacy, multiple births, and PGD.
CI  - Crown Copyright (c) 2010. Published by Elsevier Inc. All rights reserved.
FAU - Davies, Trish
AU  - Davies T
AD  - Human Fertilisation and Embryology Authority, London, United Kingdom.
      trish.davies@hfea.gov.uk
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100108
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
SB  - IM
MH  - Female
MH  - *Government Regulation
MH  - Humans
MH  - *Internationality
MH  - Male
MH  - Quality of Health Care/*legislation & jurisprudence/*standards
MH  - Reproduction
MH  - Reproductive Techniques, Assisted/adverse effects/*legislation &
      jurisprudence/*standards
MH  - United Kingdom
RF  - 13
EDAT- 2010/01/09 06:00
MHDA- 2010/06/18 06:00
CRDT- 2010/01/09 06:00
PHST- 2009/08/24 00:00 [received]
PHST- 2009/10/29 00:00 [revised]
PHST- 2009/11/04 00:00 [accepted]
PHST- 2010/01/09 06:00 [entrez]
PHST- 2010/01/09 06:00 [pubmed]
PHST- 2010/06/18 06:00 [medline]
AID - S0015-0282(09)03989-2 [pii]
AID - 10.1016/j.fertnstert.2009.11.005 [doi]
PST - ppublish
SO  - Fertil Steril. 2010 Jun;94(1):e20-2. doi: 10.1016/j.fertnstert.2009.11.005. Epub 
      2010 Jan 8.


PMID- 20055969
OWN - NLM
STAT- MEDLINE
DCOM- 20100222
LR  - 20191210
IS  - 1525-1446 (Electronic)
IS  - 0737-1209 (Linking)
VI  - 27
IP  - 1
DP  - 2010 Jan-Feb
TI  - Application of a partnership model for transformative and sustainable
      international development.
PG  - 54-70
LID - 10.1111/j.1525-1446.2009.00827.x [doi]
AB  - There are differences of intent and impact between short-term and long-term
      engagement of U.S. academic institutions with communities of need in developing
      nations. Global health programs that produce long-term transformative change
      rather than transient relief are more likely to be sustainable and in ethical
      harmony with expressed needs of a region or community. This article explores
      characteristics of successful ethical partnerships in global health and the
      challenges that threaten them, introducing a consensus community engagement model
      as a framework for building relationships, evolving an understanding of needs,
      and collaboratively developing solutions and responses to priority health needs
      in underserved regions of the world. The community engagement model is applied to
      a case study of an initiative by a U.S. school of nursing to establish long-term 
      relationships with the nursing community in the Caribbean region with the goal of
      promoting transformative change through collaborative development of programs and
      services addressing health care needs of the region's growing elderly population 
      and the increasing prevalence of noncommunicable chronic diseases. Progress of
      this ongoing long-term relationship is analyzed in the context of the
      organizational, philosophical, ethical, and resource commitments embodied in this
      approach to initiation of transformative and sustainable improvements in public
      health.
FAU - Powell, Dorothy L
AU  - Powell DL
AD  - Office of Global and Community Health Initiatives, Duke University School of
      Nursing, Durham, North Carolina 27710, USA. dorothy.powell@duke.edu
FAU - Gilliss, Catherine L
AU  - Gilliss CL
FAU - Hewitt, Hermi H
AU  - Hewitt HH
FAU - Flint, Elizabeth P
AU  - Flint EP
LA  - eng
GR  - 5H13DP0000702/DP/NCCDPHP CDC HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Public Health Nurs
JT  - Public health nursing (Boston, Mass.)
JID - 8501498
SB  - IM
MH  - Caribbean Region
MH  - Community Participation
MH  - *Community-Institutional Relations
MH  - *Cooperative Behavior
MH  - Cultural Competency/ethics/organization & administration
MH  - Developing Countries
MH  - *Global Health
MH  - Health Services Needs and Demand
MH  - Humans
MH  - *International Educational Exchange
MH  - *Models, Nursing
MH  - North Carolina
MH  - Nursing Research/ethics/organization & administration
MH  - Organizational Case Studies
MH  - Pan American Health Organization/organization & administration
MH  - Power, Psychological
MH  - Principle-Based Ethics
MH  - Program Development
MH  - Schools, Nursing/ethics/*organization & administration
MH  - Social Change
EDAT- 2010/01/09 06:00
MHDA- 2010/02/23 06:00
CRDT- 2010/01/09 06:00
PHST- 2010/01/09 06:00 [entrez]
PHST- 2010/01/09 06:00 [pubmed]
PHST- 2010/02/23 06:00 [medline]
AID - PHN827 [pii]
AID - 10.1111/j.1525-1446.2009.00827.x [doi]
PST - ppublish
SO  - Public Health Nurs. 2010 Jan-Feb;27(1):54-70. doi:
      10.1111/j.1525-1446.2009.00827.x.


PMID- 20055962
OWN - NLM
STAT- MEDLINE
DCOM- 20100222
LR  - 20100108
IS  - 1525-1446 (Electronic)
IS  - 0737-1209 (Linking)
VI  - 27
IP  - 1
DP  - 2010 Jan-Feb
TI  - Hope, ethics, and action for sustainable change.
PG  - 1-2
LID - 10.1111/j.1525-1446.2009.00820.x [doi]
FAU - Abrams, Sarah E
AU  - Abrams SE
LA  - eng
PT  - Editorial
PT  - Introductory Journal Article
PL  - United States
TA  - Public Health Nurs
JT  - Public health nursing (Boston, Mass.)
JID - 8501498
SB  - IM
MH  - *Codes of Ethics
MH  - *Health Care Reform
MH  - Health Policy
MH  - Humans
MH  - *Nurse's Role
MH  - *Social Responsibility
MH  - *Social Welfare
EDAT- 2010/01/09 06:00
MHDA- 2010/02/23 06:00
CRDT- 2010/01/09 06:00
PHST- 2010/01/09 06:00 [entrez]
PHST- 2010/01/09 06:00 [pubmed]
PHST- 2010/02/23 06:00 [medline]
AID - PHN820 [pii]
AID - 10.1111/j.1525-1446.2009.00820.x [doi]
PST - ppublish
SO  - Public Health Nurs. 2010 Jan-Feb;27(1):1-2. doi:
      10.1111/j.1525-1446.2009.00820.x.


PMID- 20055807
OWN - NLM
STAT- MEDLINE
DCOM- 20101012
LR  - 20100426
IS  - 1600-6143 (Electronic)
IS  - 1600-6135 (Linking)
VI  - 10
IP  - 3
DP  - 2010 Mar
TI  - What defines a transplant surgeon? A needs assessment for curricular development 
      in transplant surgery fellowship training.
PG  - 664-74
LID - 10.1111/j.1600-6143.2009.02956.x [doi]
AB  - This study compares the perceptions of transplant surgery program directors (PDs)
      and recent fellowship graduates (RFs) regarding the adequacy of training and
      relevancy to practice of specific curricular content items in fellowship
      training. Surveys were sent to all American Society of Transplant Surgery
      approved fellowship PDs and all RFs in practice <5 years. For operative
      procedures, the RFs considered the overall training to be less adequate than the 
      PDs (p = 0.0117), while both groups considered the procedures listed to be
      relevant to practice (p = 0.8281). Regarding nonoperative patient care items,
      although RFs tended to rank many individual items lower, both groups generally
      agreed that the training was both adequate and relevant. For nonpatient care
      related items (i.e. transplant-related ethics, economics, research, etc.), both
      groups scored them low regarding their adequacy of training although RFs scored
      them significantly lower than PDs (p = 0.0006). Regarding their relevance to
      practice, while both groups considered these items relevant, RFs generally
      considered them more relevant than PDs. Therefore, although there is consensus on
      many items, significant differences exist between PDs and RFs regarding their
      perceptions of the adequacy of training and the relevance to practice of specific
      curriculum items in transplant surgery fellowship training.
FAU - Fryer, J
AU  - Fryer J
AD  - Department of Surgery, Northwestern University Feinberg School of Medicine,
      Chicago, IL, USA. jfryer@nmh.org
FAU - DaRosa, D A
AU  - DaRosa DA
FAU - Wang, E
AU  - Wang E
FAU - Han, L
AU  - Han L
FAU - Axelrod, D
AU  - Axelrod D
FAU - Ishitani, M
AU  - Ishitani M
FAU - Baker, T
AU  - Baker T
FAU - Knight, R
AU  - Knight R
FAU - Sung, R
AU  - Sung R
FAU - Magee, J
AU  - Magee J
FAU - Pomfret, E A
AU  - Pomfret EA
CN  - ASTS National Transplant Surgery Curriculum Committee
LA  - eng
PT  - Journal Article
DEP - 20100105
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
SB  - IM
MH  - Curriculum
MH  - Ethics, Medical
MH  - Fellowships and Scholarships
MH  - General Surgery/*education/methods
MH  - Humans
MH  - Needs Assessment
MH  - Organ Transplantation/*education/*methods
MH  - Physicians
EDAT- 2010/01/09 06:00
MHDA- 2010/10/13 06:00
CRDT- 2010/01/09 06:00
PHST- 2010/01/09 06:00 [entrez]
PHST- 2010/01/09 06:00 [pubmed]
PHST- 2010/10/13 06:00 [medline]
AID - AJT2956 [pii]
AID - 10.1111/j.1600-6143.2009.02956.x [doi]
PST - ppublish
SO  - Am J Transplant. 2010 Mar;10(3):664-74. doi: 10.1111/j.1600-6143.2009.02956.x.
      Epub 2010 Jan 5.


PMID- 20054575
OWN - NLM
STAT- MEDLINE
DCOM- 20101014
LR  - 20211020
IS  - 1432-2218 (Electronic)
IS  - 0930-2794 (Linking)
VI  - 24
IP  - 7
DP  - 2010 Jul
TI  - EAES recommendations on methodology of innovation management in endoscopic
      surgery.
PG  - 1594-615
LID - 10.1007/s00464-009-0818-3 [doi]
AB  - BACKGROUND: Under the mandate of the European Association for Endoscopic Surgery 
      (EAES) a guideline on methodology of innovation management in endoscopic surgery 
      has been developed. The primary focus of this guideline is patient safety,
      efficacy, and effectiveness. METHODS: An international expert panel was invited
      to develop recommendations for the assessment and introduction of surgical
      innovations. A consensus development conference (CDC) took place in May 2009
      using the method of a nominal group process (NGP). The recommendations were
      presented at the annual EAES congress in Prague, Czech Republic, on June 18th,
      2009 for discussion and further input. After further Delphi processes between the
      experts, the final recommendations were agreed upon. RESULTS: The development and
      implementation of innovations in surgery are addressed in five sections: (1)
      definition of an innovation, (2) preclinical and (3) clinical scientific
      development, (4) scientific approval, and (5) implementation along with
      monitoring. Within the present guideline each of the sections and several steps
      are defined, and several recommendations based on available evidence have been
      agreed within each category. A comprehensive workflow of the different steps is
      given in an algorithm. In addition, issues of health technology assessment (HTA) 
      serving to estimate efficiency followed by ethical directives are given.
      CONCLUSIONS: Innovations into clinical practice should be introduced with the
      highest possible grade of safety for the patient (nil nocere: do no harm). The
      recommendations can contribute to the attainment of this objective without
      preventing future promising diagnostic and therapeutic innovations in the field
      of surgery and allied techniques.
FAU - Neugebauer, Edmund A M
AU  - Neugebauer EA
AD  - Institute for Research in Operative Medicine, Faculty of Medicine, Campus
      Cologne-Merheim, University of Witten/Herdecke, Ostmerheimer Str. 200, 51109,
      Cologne, Germany. edmund.neugebauer@uni-wh.de
FAU - Becker, Monika
AU  - Becker M
FAU - Buess, Gerhard F
AU  - Buess GF
FAU - Cuschieri, Alfred
AU  - Cuschieri A
FAU - Dauben, Hans-Peter
AU  - Dauben HP
FAU - Fingerhut, Abe
AU  - Fingerhut A
FAU - Fuchs, Karl H
AU  - Fuchs KH
FAU - Habermalz, Brigitte
AU  - Habermalz B
FAU - Lantsberg, Leonid
AU  - Lantsberg L
FAU - Morino, Mario
AU  - Morino M
FAU - Reiter-Theil, Stella
AU  - Reiter-Theil S
FAU - Soskuty, Gabriela
AU  - Soskuty G
FAU - Wayand, Wolfgang
AU  - Wayand W
FAU - Welsch, Thilo
AU  - Welsch T
CN  - European Association for Endoscopic Surgery (EAES)
LA  - eng
PT  - Journal Article
PT  - Practice Guideline
DEP - 20100107
PL  - Germany
TA  - Surg Endosc
JT  - Surgical endoscopy
JID - 8806653
SB  - IM
MH  - *Diffusion of Innovation
MH  - *Endoscopy
MH  - Humans
MH  - *Technology Assessment, Biomedical
MH  - Treatment Outcome
MH  - Workflow
EDAT- 2010/01/08 06:00
MHDA- 2010/10/15 06:00
CRDT- 2010/01/08 06:00
PHST- 2009/11/03 00:00 [received]
PHST- 2009/11/23 00:00 [accepted]
PHST- 2010/01/08 06:00 [entrez]
PHST- 2010/01/08 06:00 [pubmed]
PHST- 2010/10/15 06:00 [medline]
AID - 10.1007/s00464-009-0818-3 [doi]
PST - ppublish
SO  - Surg Endosc. 2010 Jul;24(7):1594-615. doi: 10.1007/s00464-009-0818-3. Epub 2010
      Jan 7.


PMID- 20054041
OWN - NLM
STAT- MEDLINE
DCOM- 20100511
LR  - 20100205
IS  - 1049-7323 (Print)
IS  - 1049-7323 (Linking)
VI  - 20
IP  - 3
DP  - 2010 Mar
TI  - Women's experiences of their violent behavior in an intimate partner
      relationship.
PG  - 306-18
LID - 10.1177/1049732309358325 [doi]
AB  - The purpose of this study was to describe women's perceptions of their violent
      behavior in a heterosexual partnership. The study followed the traditions of
      Husserlian descriptive phenomenology and the philosophy of existential
      phenomenology. Twenty-four volunteer Finnish women, aged 19 to 58 years, with a
      history of different manifestations of intimate partner violence (IPV)
      participated in open-ended interviews. The data were analyzed by the method
      developed by Colaizzi. The findings revealed that some of the women who opposed
      all violence on ethical grounds did not label their behavior as violent; some
      others minimized or justified their violent behavior. The findings offer
      professional insight into women's violent behavior and call for a readjustment in
      approaches to work in the area. Prevention and early identification of IPV
      require knowledge of the various manifestations and individual meanings of
      violence. Helping methods should provide women with the opportunity to talk about
      their abusive behavior and to confront and address their feelings of guilt,
      disappointment, and shame.
FAU - Flinck, Aune
AU  - Flinck A
AD  - University of Tampere, Tampere, Finland. aune.flinck@uta.fi
FAU - Paavilainen, Eija
AU  - Paavilainen E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100106
PL  - United States
TA  - Qual Health Res
JT  - Qualitative health research
JID - 9202144
MH  - Adult
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - *Self Concept
MH  - Sexual Partners/*psychology
MH  - *Social Perception
MH  - Spouse Abuse/*psychology
MH  - Women/*psychology
MH  - Young Adult
EDAT- 2010/01/08 06:00
MHDA- 2010/05/12 06:00
CRDT- 2010/01/08 06:00
PHST- 2010/01/08 06:00 [entrez]
PHST- 2010/01/08 06:00 [pubmed]
PHST- 2010/05/12 06:00 [medline]
AID - 1049732309358325 [pii]
AID - 10.1177/1049732309358325 [doi]
PST - ppublish
SO  - Qual Health Res. 2010 Mar;20(3):306-18. doi: 10.1177/1049732309358325. Epub 2010 
      Jan 6.


PMID- 20054012
OWN - NLM
STAT- MEDLINE
DCOM- 20100323
LR  - 20100114
IS  - 1744-5019 (Electronic)
IS  - 0360-5310 (Linking)
VI  - 35
IP  - 1
DP  - 2010 Feb
TI  - Disambiguating clinical intentions: the ethics of palliative sedation.
PG  - 19-31
LID - 10.1093/jmp/jhp056 [doi]
AB  - It is often claimed that the intentions of physicians are multiple, ambiguous,
      and uncertain-at least with respect to end-of-life care. This claim provides
      support for the conclusion that the principle of double effect is of little or no
      value as a guide to end-of-life pain management. This paper critically discusses 
      this claim. It argues that proponents of the claim fail to distinguish two
      different senses of "intention," and that, as a result, they are led to
      exaggerate the extent to which clinical intentions in end-of-life contexts are
      ambiguous and uncertain. It argues further that physicians, like others who make 
      life and death decisions, have a duty to get clear on what their intentions are. 
      Finally, it argues that even if the principle of double effect should be
      rejected, clinical intentions remain ethically significant because they condition
      the meaning of extraordinary clinical interventions, such as that of palliative
      sedation.
FAU - Jansen, Lynn A
AU  - Jansen LA
AD  - The John J. Conley Department of Ethics at St. Vincent's, Manhattan, 153 West
      11th Street (NR 815), New York, NY 10011, USA. ljansen@svcmcny.org
LA  - eng
PT  - Journal Article
DEP - 20100106
PL  - United States
TA  - J Med Philos
JT  - The Journal of medicine and philosophy
JID - 7610512
RN  - 0 (Hypnotics and Sedatives)
RN  - 0 (Narcotics)
SB  - IM
MH  - Ethical Analysis
MH  - Euthanasia, Active/*ethics/methods/psychology
MH  - Humans
MH  - Hypnotics and Sedatives/therapeutic use
MH  - *Intention
MH  - Narcotics/therapeutic use
MH  - Pain/drug therapy
MH  - Palliative Care/*ethics/methods/*psychology
MH  - Philosophy, Medical
MH  - Terminal Care/*ethics/methods/psychology
EDAT- 2010/01/08 06:00
MHDA- 2010/03/24 06:00
CRDT- 2010/01/08 06:00
PHST- 2010/01/08 06:00 [entrez]
PHST- 2010/01/08 06:00 [pubmed]
PHST- 2010/03/24 06:00 [medline]
AID - jhp056 [pii]
AID - 10.1093/jmp/jhp056 [doi]
PST - ppublish
SO  - J Med Philos. 2010 Feb;35(1):19-31. doi: 10.1093/jmp/jhp056. Epub 2010 Jan 6.


PMID- 20054011
OWN - NLM
STAT- MEDLINE
DCOM- 20100323
LR  - 20100114
IS  - 1744-5019 (Electronic)
IS  - 0360-5310 (Linking)
VI  - 35
IP  - 1
DP  - 2010 Feb
TI  - Clinical research in context: reexamining the distinction between research and
      practice.
PG  - 46-63
LID - 10.1093/jmp/jhp054 [doi]
AB  - At least since the seminal work of the (US) National Commission for the
      Protection of Human Subjects of Biomedical and Behavioral Research in the 1970s, 
      a fundamental distinction between research and practice has underwritten both
      conceptual work in research ethics and regulations governing research involving
      human subjects. Notwithstanding its undoubted historical importance, I believe
      the distinction is problematic because it misrepresents clinical inquiry. In this
      essay, I aim to clarify the character of clinical inquiry by identifying crucial 
      contextual constraints on justification constitutive of clinical science. This
      analysis shows that, from an epistemological point of view, clinical research and
      clinical practice are not sharply distinct but intimately intertwined. This
      result is important in its own right-an enriched understanding of the
      epistemology of clinical research is valuable in and of itself. But this result
      is also important because it has profound implications for the ethics of human
      subjects research.
FAU - Anderson, James A
AU  - Anderson JA
AD  - Biomedical Ethics Unit, 3647 Peel Street, Montreal, QC H3A 1X1, Canada.
      james.anderson@mail.mcgill.ca
LA  - eng
PT  - Journal Article
DEP - 20100106
PL  - United States
TA  - J Med Philos
JT  - The Journal of medicine and philosophy
JID - 7610512
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Diffusion of Innovation
MH  - Evidence-Based Medicine/ethics
MH  - Humans
MH  - Medicine/*organization & administration
MH  - Philosophy, Medical
MH  - Research Subjects
EDAT- 2010/01/08 06:00
MHDA- 2010/03/24 06:00
CRDT- 2010/01/08 06:00
PHST- 2010/01/08 06:00 [entrez]
PHST- 2010/01/08 06:00 [pubmed]
PHST- 2010/03/24 06:00 [medline]
AID - jhp054 [pii]
AID - 10.1093/jmp/jhp054 [doi]
PST - ppublish
SO  - J Med Philos. 2010 Feb;35(1):46-63. doi: 10.1093/jmp/jhp054. Epub 2010 Jan 6.


PMID- 20053723
OWN - NLM
STAT- MEDLINE
DCOM- 20100329
LR  - 20220408
IS  - 1741-2854 (Electronic)
IS  - 0020-7640 (Linking)
VI  - 56
IP  - 1
DP  - 2010 Jan
TI  - Mental health service users' perceptions and experiences of sedation, seclusion
      and restraint.
PG  - 60-73
LID - 10.1177/0020764008098293 [doi]
AB  - BACKGROUND: Sedation, seclusion or restraint are recognized methods of containing
      a person experiencing an acute psychotic episode with behavioural disturbance
      which has not responded to verbal or non-sedating pharmacological interventions. 
      These interventions pose significant ethical and practical challenges to service 
      providers who are responsible for safeguarding the human rights of mental health 
      service users. AIMS: In a collaborative two-phase study between mental health
      care providers and mental health service users, the perceptions and experiences
      of a group of service users who have been exposed to sedation, seclusion and
      restraint were explored. METHOD: A focus group was conducted with eight service
      users. The content of the focus group was transcribed and themes were identified 
      using thematic analysis. These were presented to a second focus group consisting 
      of eight other service users for validation and comment. Based on the results of 
      the focus groups, a questionnaire was developed and administered to a convenience
      sample of 43 service users in three localities. RESULTS: Service users reported
      inadequate communication between them and service providers and perceived that
      their human rights had been infringed during acute episodes of illness. METHODS: 
      of containment were often seen as punitive rather than therapeutic. Sedation was 
      most frequently used and was considered to be least distressing. Observing
      methods of forced/involuntary containment caused further distress. CONCLUSIONS:
      There is a need to humanize service users' experiences during episodes of acute
      illness. Measures should include prevention of human rights abuses; minimization 
      of isolation and distress; improvement of communication between service providers
      and service users; and promotion of attitudinal changes which reflect respect for
      other people's dignity.
FAU - Mayers, Pat
AU  - Mayers P
AD  - Division of Nursing and Midwifery, School of Health and Rehabilitation Sciences, 
      Faculty of Health Sciences, University of Cape Town, Observatory 7925, South
      Africa. Pat.Mayers@uct.ac.za
FAU - Keet, Nelleke
AU  - Keet N
FAU - Winkler, Gunter
AU  - Winkler G
FAU - Flisher, Alan J
AU  - Flisher AJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Soc Psychiatry
JT  - The International journal of social psychiatry
JID - 0374726
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Communication
MH  - Conscious Sedation/*psychology
MH  - Deinstitutionalization
MH  - Emergency Services, Psychiatric
MH  - Female
MH  - Focus Groups
MH  - Humans
MH  - Interview, Psychological
MH  - Male
MH  - Middle Aged
MH  - Patient Acceptance of Health Care/psychology
MH  - Patient Advocacy/*psychology
MH  - Patient Isolation/*psychology
MH  - Pilot Projects
MH  - Professional-Patient Relations
MH  - Psychotic Disorders/psychology/*therapy
MH  - Punishment
MH  - Restraint, Physical/*psychology
MH  - Social Environment
MH  - Social Support
MH  - South Africa
EDAT- 2010/01/08 06:00
MHDA- 2010/03/30 06:00
CRDT- 2010/01/08 06:00
PHST- 2010/01/08 06:00 [entrez]
PHST- 2010/01/08 06:00 [pubmed]
PHST- 2010/03/30 06:00 [medline]
AID - 56/1/60 [pii]
AID - 10.1177/0020764008098293 [doi]
PST - ppublish
SO  - Int J Soc Psychiatry. 2010 Jan;56(1):60-73. doi: 10.1177/0020764008098293.


PMID- 20053272
OWN - NLM
STAT- MEDLINE
DCOM- 20100802
LR  - 20220411
IS  - 1471-2288 (Electronic)
IS  - 1471-2288 (Linking)
VI  - 10
DP  - 2010 Jan 6
TI  - A tutorial on pilot studies: the what, why and how.
PG  - 1
LID - 10.1186/1471-2288-10-1 [doi]
AB  - Pilot studies for phase III trials - which are comparative randomized trials
      designed to provide preliminary evidence on the clinical efficacy of a drug or
      intervention - are routinely performed in many clinical areas. Also commonly know
      as "feasibility" or "vanguard" studies, they are designed to assess the safety of
      treatment or interventions; to assess recruitment potential; to assess the
      feasibility of international collaboration or coordination for multicentre
      trials; to increase clinical experience with the study medication or intervention
      for the phase III trials. They are the best way to assess feasibility of a large,
      expensive full-scale study, and in fact are an almost essential pre-requisite.
      Conducting a pilot prior to the main study can enhance the likelihood of success 
      of the main study and potentially help to avoid doomed main studies. The
      objective of this paper is to provide a detailed examination of the key aspects
      of pilot studies for phase III trials including: 1) the general reasons for
      conducting a pilot study; 2) the relationships between pilot studies,
      proof-of-concept studies, and adaptive designs; 3) the challenges of and
      misconceptions about pilot studies; 4) the criteria for evaluating the success of
      a pilot study; 5) frequently asked questions about pilot studies; 7) some ethical
      aspects related to pilot studies; and 8) some suggestions on how to report the
      results of pilot investigations using the CONSORT format.
FAU - Thabane, Lehana
AU  - Thabane L
AD  - Department of Clinical Epidemiology and Biostatistics, McMaster University,
      Hamilton ON, Canada. thabanl@mcmaster.ca
FAU - Ma, Jinhui
AU  - Ma J
FAU - Chu, Rong
AU  - Chu R
FAU - Cheng, Ji
AU  - Cheng J
FAU - Ismaila, Afisi
AU  - Ismaila A
FAU - Rios, Lorena P
AU  - Rios LP
FAU - Robson, Reid
AU  - Robson R
FAU - Thabane, Marroon
AU  - Thabane M
FAU - Giangregorio, Lora
AU  - Giangregorio L
FAU - Goldsmith, Charles H
AU  - Goldsmith CH
LA  - eng
PT  - Journal Article
DEP - 20100106
PL  - England
TA  - BMC Med Res Methodol
JT  - BMC medical research methodology
JID - 100968545
SB  - IM
MH  - Clinical Trials, Phase III as Topic/methods
MH  - Humans
MH  - *Pilot Projects
MH  - Randomized Controlled Trials as Topic
MH  - *Research Design/standards
PMC - PMC2824145
EDAT- 2010/01/08 06:00
MHDA- 2010/08/03 06:00
CRDT- 2010/01/08 06:00
PHST- 2009/08/09 00:00 [received]
PHST- 2010/01/06 00:00 [accepted]
PHST- 2010/01/08 06:00 [entrez]
PHST- 2010/01/08 06:00 [pubmed]
PHST- 2010/08/03 06:00 [medline]
AID - 1471-2288-10-1 [pii]
AID - 10.1186/1471-2288-10-1 [doi]
PST - epublish
SO  - BMC Med Res Methodol. 2010 Jan 6;10:1. doi: 10.1186/1471-2288-10-1.


PMID- 20052956
OWN - NLM
STAT- MEDLINE
DCOM- 20100212
LR  - 20100107
IS  - 1532-0650 (Electronic)
IS  - 0002-838X (Linking)
VI  - 81
IP  - 1
DP  - 2010 Jan 1
TI  - The ethical dilemma of life-prolonging medical devices.
PG  - 15
FAU - Clausen, Shawn
AU  - Clausen S
LA  - eng
PT  - Comment
PT  - Letter
PL  - United States
TA  - Am Fam Physician
JT  - American family physician
JID - 1272646
SB  - IM
CON - Am Fam Physician. 2008 Aug 1;78(3):398-9. PMID: 18711956
MH  - Humans
MH  - Life Support Care/ethics
MH  - *Pacemaker, Artificial
MH  - Withholding Treatment/*ethics
EDAT- 2010/01/08 06:00
MHDA- 2010/02/13 06:00
CRDT- 2010/01/08 06:00
PHST- 2010/01/08 06:00 [entrez]
PHST- 2010/01/08 06:00 [pubmed]
PHST- 2010/02/13 06:00 [medline]
PST - ppublish
SO  - Am Fam Physician. 2010 Jan 1;81(1):15.


PMID- 20052490
OWN - NLM
STAT- MEDLINE
DCOM- 20100903
LR  - 20211020
IS  - 1432-1076 (Electronic)
IS  - 0340-6199 (Linking)
VI  - 169
IP  - 7
DP  - 2010 Jul
TI  - Successful cord blood transplantation for a CHARGE syndrome with CHD7 mutation
      showing DiGeorge sequence including hypoparathyroidism.
PG  - 839-44
LID - 10.1007/s00431-009-1126-6 [doi]
AB  - It is rare that coloboma, heart anomalies, choanal atresia, retarded growth and
      development, and genital and ear anomalies (CHARGE) syndrome patients have
      DiGeorge sequence showing severe immunodeficiency due to the defect of the
      thymus. Although the only treatment to achieve immunological recovery for these
      patients in countries where thymic transplantation is not ethically approved
      would be hematopoietic cell transplantation, long-term survival has not been
      obtained in most patients. On the other hand, it is still not clarified whether
      hypoparathyroidism is one of the manifestations of CHARGE syndrome. We observed a
      CHARGE syndrome patient with chromodomain helicase DNA-binding protein 7 mutation
      showing DiGeorge sequence including the defect of T cells accompanied with the
      aplasia of the thymus, severe hypoparathyroidism, and conotruncal cardiac
      anomaly. He received unrelated cord blood transplantation without conditioning at
      4 months of age. Recovery of T cell number and of proliferative response against 
      mitogens was achieved by peripheral expansion of mature T cells in cord blood
      without thymic output. Although he is still suffering from severe
      hypoparathyroidism, he is alive without serious infections for 10 months.
FAU - Inoue, Hirosuke
AU  - Inoue H
AD  - Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University,
      3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
FAU - Takada, Hidetoshi
AU  - Takada H
FAU - Kusuda, Takeshi
AU  - Kusuda T
FAU - Goto, Takako
AU  - Goto T
FAU - Ochiai, Masayuki
AU  - Ochiai M
FAU - Kinjo, Tadamune
AU  - Kinjo T
FAU - Muneuchi, Jun
AU  - Muneuchi J
FAU - Takahata, Yasushi
AU  - Takahata Y
FAU - Takahashi, Naomi
AU  - Takahashi N
FAU - Morio, Tomohiro
AU  - Morio T
FAU - Kosaki, Kenjiro
AU  - Kosaki K
FAU - Hara, Toshiro
AU  - Hara T
LA  - eng
PT  - Journal Article
DEP - 20100106
PL  - Germany
TA  - Eur J Pediatr
JT  - European journal of pediatrics
JID - 7603873
RN  - 0 (CDH7 protein, human)
RN  - 0 (Cadherins)
SB  - IM
MH  - Abnormalities, Multiple/genetics/*therapy
MH  - Cadherins/*genetics
MH  - Choanal Atresia
MH  - Coloboma
MH  - *Cord Blood Stem Cell Transplantation
MH  - DiGeorge Syndrome/genetics/*therapy
MH  - Ear/abnormalities
MH  - Heart Defects, Congenital
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - *Mutation
MH  - Syndrome
EDAT- 2010/01/07 06:00
MHDA- 2010/09/04 06:00
CRDT- 2010/01/07 06:00
PHST- 2009/07/22 00:00 [received]
PHST- 2009/12/01 00:00 [accepted]
PHST- 2010/01/07 06:00 [entrez]
PHST- 2010/01/07 06:00 [pubmed]
PHST- 2010/09/04 06:00 [medline]
AID - 10.1007/s00431-009-1126-6 [doi]
PST - ppublish
SO  - Eur J Pediatr. 2010 Jul;169(7):839-44. doi: 10.1007/s00431-009-1126-6. Epub 2010 
      Jan 6.


PMID- 20051713
OWN - NLM
STAT- MEDLINE
DCOM- 20100701
LR  - 20181201
IS  - 1660-5535 (Electronic)
IS  - 1660-5527 (Linking)
VI  - 23
IP  - 3
DP  - 2010
TI  - Functional characterization of calcium-signaling pathways of human skin-derived
      mesenchymal stem cells.
PG  - 124-32
LID - 10.1159/000270383 [doi]
AB  - BACKGROUND: Mesenchymal stem cells (MSCs) derived from adult human tissues are
      able to differentiate into various specialized cell types. In research, they can 
      therefore be used like embryonic cells but without the ethical restrictions.
      Among the various human tissues, skin as a source is characterized by great
      accessibility and availability using noninvasive procedures and is without the
      risk of oncogenesis after transplantation. The recent isolation of MSCs has shown
      the lack of knowledge regarding their specific features, including the
      calcium-signaling pathways. METHODS: In this study, we isolated MSCs from human
      skin biopsies (S-MSCs) and characterized them phenotypically and their
      calcium-signaling pathways by the means of Ca2+ imaging and video microscopic
      experiments. RESULTS: The cytofluorimetric analysis of the expression of surface 
      markers on S-MSCs revealed that they express the normal pattern present on MSCs. 
      Interestingly, these cells appeared to be successfully cryopreserved at early
      passages. Calcium imaging on single S-MSCs shows that these cells did not display
      significant spontaneous activity or a response to a depolarizing agent. However, 
      ATP or acetylcholine-induced intracellular calcium increase via ionotropic or
      metabotropic receptors, respectively. CONCLUSION: The results presented here
      reveal that S-MSCs show morphological and functional features that make them
      useful as an in vitro model to study cell differentiation.
CI  - Copyright 2009 S. Karger AG, Basel.
FAU - Orciani, M
AU  - Orciani M
AD  - Department of Molecular Pathology and Innovative Therapies, Histology Section,
      Marche Polytechnic University, Ancona, Italy.
FAU - Mariggio, M A
AU  - Mariggio MA
FAU - Morabito, C
AU  - Morabito C
FAU - Di Benedetto, G
AU  - Di Benedetto G
FAU - Di Primio, R
AU  - Di Primio R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091223
PL  - Switzerland
TA  - Skin Pharmacol Physiol
JT  - Skin pharmacology and physiology
JID - 101188418
RN  - 0 (Receptors, Cholinergic)
RN  - 0 (Receptors, Purinergic)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
RN  - N9YNS0M02X (Acetylcholine)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Acetylcholine/pharmacology
MH  - Adenosine Triphosphate/pharmacology
MH  - Adult
MH  - Calcium/*metabolism
MH  - *Calcium Signaling
MH  - Cell Differentiation/physiology
MH  - Cryopreservation
MH  - Flow Cytometry
MH  - Humans
MH  - Mesenchymal Stem Cells/*metabolism
MH  - Models, Biological
MH  - Receptors, Cholinergic/metabolism
MH  - Receptors, Purinergic/metabolism
EDAT- 2010/01/07 06:00
MHDA- 2010/07/02 06:00
CRDT- 2010/01/07 06:00
PHST- 2009/05/28 00:00 [received]
PHST- 2009/09/25 00:00 [accepted]
PHST- 2010/01/07 06:00 [entrez]
PHST- 2010/01/07 06:00 [pubmed]
PHST- 2010/07/02 06:00 [medline]
AID - 000270383 [pii]
AID - 10.1159/000270383 [doi]
PST - ppublish
SO  - Skin Pharmacol Physiol. 2010;23(3):124-32. doi: 10.1159/000270383. Epub 2009 Dec 
      23.


PMID- 20051638
OWN - NLM
STAT- MEDLINE
DCOM- 20100120
LR  - 20220309
IS  - 1558-8238 (Electronic)
IS  - 0021-9738 (Linking)
VI  - 120
IP  - 1
DP  - 2010 Jan
TI  - The bioethics of stem cell research and therapy.
PG  - 71-5
LID - 10.1172/JCI40435 [doi]
LID - 40435 [pii]
AB  - Discussion of the bioethics of human stem cell research has transitioned from
      controversies over the source of human embryonic stem cells to concerns about the
      ethical use of stem cells in basic and clinical research. Key areas in this
      evolving ethical discourse include the derivation and use of other human
      embryonic stem cell-like stem cells that have the capacity to differentiate into 
      all types of human tissue and the use of all types of stem cells in clinical
      research. Each of these issues is discussed as I summarize the past, present, and
      future bioethical issues in stem cell research.
FAU - Hyun, Insoo
AU  - Hyun I
AD  - Department of Bioethics, Case Western Reserve University, School of Medicine,
      10900 Euclid Avenue, Cleveland, Ohio 44106-4976, USA. insoo.hyun@case.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Clin Invest
JT  - The Journal of clinical investigation
JID - 7802877
RN  - 0 (CDX2 Transcription Factor)
RN  - 0 (CDX2 protein, human)
RN  - 0 (Homeodomain Proteins)
SB  - IM
MH  - Animals
MH  - *Bioethical Issues
MH  - CDX2 Transcription Factor
MH  - Embryo Research/*ethics
MH  - Embryonic Stem Cells
MH  - Homeodomain Proteins/genetics
MH  - Humans
MH  - Mice
MH  - Pluripotent Stem Cells
MH  - Stem Cell Transplantation/*ethics
RF  - 33
PMC - PMC2798696
EDAT- 2010/01/07 06:00
MHDA- 2010/01/21 06:00
CRDT- 2010/01/07 06:00
PHST- 2010/01/07 06:00 [entrez]
PHST- 2010/01/07 06:00 [pubmed]
PHST- 2010/01/21 06:00 [medline]
AID - 40435 [pii]
AID - 10.1172/JCI40435 [doi]
PST - ppublish
SO  - J Clin Invest. 2010 Jan;120(1):71-5. doi: 10.1172/JCI40435.


PMID- 20051439
OWN - NLM
STAT- MEDLINE
DCOM- 20110729
LR  - 20100106
IS  - 1471-8405 (Electronic)
IS  - 0962-7480 (Linking)
VI  - 60
IP  - 1
DP  - 2010 Jan
TI  - GMC guidance on confidentiality: is it ethical?
PG  - 6-7
LID - 10.1093/occmed/kqp186 [doi]
FAU - Tamin, Jacques
AU  - Tamin J
LA  - eng
PT  - Editorial
PL  - England
TA  - Occup Med (Lond)
JT  - Occupational medicine (Oxford, England)
JID - 9205857
SB  - IM
CIN - Occup Med (Lond). 2010 May;60(3):236. PMID: 20423953
CIN - Occup Med (Lond). 2010 Jun;60(4):315. PMID: 20511273
MH  - Attitude of Health Personnel
MH  - *Confidentiality
MH  - *Ethics, Medical
MH  - *Guidelines as Topic
MH  - Humans
MH  - *Occupational Medicine/ethics
EDAT- 2010/01/07 06:00
MHDA- 2011/07/30 06:00
CRDT- 2010/01/07 06:00
PHST- 2010/01/07 06:00 [entrez]
PHST- 2010/01/07 06:00 [pubmed]
PHST- 2011/07/30 06:00 [medline]
AID - kqp186 [pii]
AID - 10.1093/occmed/kqp186 [doi]
PST - ppublish
SO  - Occup Med (Lond). 2010 Jan;60(1):6-7. doi: 10.1093/occmed/kqp186.


PMID- 20051429
OWN - NLM
STAT- MEDLINE
DCOM- 20100317
LR  - 20211020
IS  - 1461-7196 (Electronic)
IS  - 1363-4593 (Linking)
VI  - 14
IP  - 1
DP  - 2010 Jan
TI  - A 'healthy baby': The double imperative of preimplantation genetic diagnosis.
PG  - 41-56
LID - 10.1177/1363459309347477 [doi]
AB  - This article reports from a study exploring the social processes, meanings and
      institutions that frame and produce 'ethical problems' and clinical dilemmas for 
      practitioners, scientists and others working in the specialty of preimplantation 
      genetic diagnosis (PGD). A major topic in the data was that, in contrast to IVF, 
      the aim of PGD is to transfer to the woman's womb only those embryos likely to be
      unaffected by serious genetic disorders; that is, to produce 'healthy babies'.
      Staff described the complex processes through which embryos in each treatment
      cycle must meet a double imperative: they must be judged viable by embryologists 
      and 'unaffected' by geneticists. In this article, we focus on some of the
      ethical, social and occupational issues for staff ensuing from PGD's double
      imperative.
FAU - Ehrich, Kathryn
AU  - Ehrich K
AD  - Centre for Biomedicine & Society, King's College London, Strand, London, UK.
      Kathryn.Ehrich@kcl.ac.uk
FAU - Williams, Clare
AU  - Williams C
LA  - eng
GR  - 086034/WT_/Wellcome Trust/United Kingdom
GR  - 081414/WT_/Wellcome Trust/United Kingdom
GR  - 074935/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Health (London)
JT  - Health (London, England : 1997)
JID - 9800465
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Decision Making
MH  - Embryology/*ethics
MH  - Female
MH  - Fertilization in Vitro
MH  - Genetic Testing/*ethics
MH  - Humans
MH  - Pregnancy
MH  - Preimplantation Diagnosis/*ethics/*psychology
MH  - Qualitative Research
EDAT- 2010/01/07 06:00
MHDA- 2010/03/18 06:00
CRDT- 2010/01/07 06:00
PHST- 2010/01/07 06:00 [entrez]
PHST- 2010/01/07 06:00 [pubmed]
PHST- 2010/03/18 06:00 [medline]
AID - 14/1/41 [pii]
AID - 10.1177/1363459309347477 [doi]
PST - ppublish
SO  - Health (London). 2010 Jan;14(1):41-56. doi: 10.1177/1363459309347477.


PMID- 20051408
OWN - NLM
STAT- MEDLINE
DCOM- 20100202
LR  - 20181204
IS  - 1931-3543 (Electronic)
IS  - 0012-3692 (Linking)
VI  - 137
IP  - 1
DP  - 2010 Jan
TI  - The committee on publication ethics flowcharts.
PG  - 221-3
LID - 10.1378/chest.09-1565 [doi]
FAU - Wager, Elizabeth
AU  - Wager E
AD  - liz@sideview.demon.co.uk
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Chest
JT  - Chest
JID - 0231335
SB  - IM
MH  - Ethics Committees/*organization & administration
MH  - Humans
MH  - Periodicals as Topic/*ethics
MH  - *Software Design
EDAT- 2010/01/07 06:00
MHDA- 2010/02/03 06:00
CRDT- 2010/01/07 06:00
PHST- 2010/01/07 06:00 [entrez]
PHST- 2010/01/07 06:00 [pubmed]
PHST- 2010/02/03 06:00 [medline]
AID - S0012-3692(10)60038-4 [pii]
AID - 10.1378/chest.09-1565 [doi]
PST - ppublish
SO  - Chest. 2010 Jan;137(1):221-3. doi: 10.1378/chest.09-1565.


PMID- 20051289
OWN - NLM
STAT- MEDLINE
DCOM- 20100525
LR  - 20211020
IS  - 1873-6386 (Electronic)
IS  - 0160-2527 (Linking)
VI  - 33
IP  - 2
DP  - 2010 Mar-Apr
TI  - Dangerous and severe personality disorder: An investigation of the construct.
PG  - 84-8
LID - 10.1016/j.ijlp.2009.12.008 [doi]
AB  - Introduction of the construct "Dangerous and Severe Personality Disorder" (DSPD) 
      by the UK Home Office and Department of Health has provoked strong debate and
      opposition. Its aims and that of proposed subsequent legislation was to enhance
      public protection by identifying and detaining a minority of persons with severe 
      personality disorder who pose a high risk of serious sexual/violent offending.
      The most serious criticism was the ethical implication of allowing indefinite
      detention of people without criminal convictions. More recently, policy emphasis 
      has shifted towards treatment. 1396 male prisoners serving sentences of 2+years
      for sexual/violent offenses were prospectively interviewed (personality
      disorders, psychopathy, and risk) at a mean follow-up of 2 years. The prevalence 
      of DSPD was 15%. Significantly more re-offended. Five DSPD offenders would need
      treatment to prevent one violent act. Based on an estimate of attributable risk, 
      successful treatment of DSPD could reduce violent re-convictions among DSPD
      offenders by 71% and violent/sexual re-offenses in the prison population by 27%. 
      DSPD criteria correctly identify high risk prisoners but primarily through
      risk-related demographic features. DSPD does not accurately identify serious
      sexual/violent re-offenders. The DSPD programme may reduce major violent
      re-offending if treatment interventions prove effective.
CI  - Copyright 2009 Elsevier Ltd. All rights reserved.
FAU - Ullrich, Simone
AU  - Ullrich S
AD  - Queen Mary University of London, Barts and the London School of Medicine and
      Dentistry, Forensic Psychiatry Research Unit, London, UK. s.ullrich@qmul.ac.uk
FAU - Yang, Min
AU  - Yang M
FAU - Coid, Jeremy
AU  - Coid J
LA  - eng
GR  - RP-PG-0407-10500/DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100103
PL  - Netherlands
TA  - Int J Law Psychiatry
JT  - International journal of law and psychiatry
JID - 7806862
SB  - IM
MH  - Adult
MH  - *Dangerous Behavior
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - *Personality Disorders/epidemiology
MH  - Prisoners/*psychology
MH  - Prospective Studies
MH  - Risk Assessment
MH  - *Safety
MH  - *Severity of Illness Index
MH  - United Kingdom/epidemiology
MH  - Young Adult
EDAT- 2010/01/07 06:00
MHDA- 2010/05/26 06:00
CRDT- 2010/01/07 06:00
PHST- 2010/01/07 06:00 [entrez]
PHST- 2010/01/07 06:00 [pubmed]
PHST- 2010/05/26 06:00 [medline]
AID - S0160-2527(09)00138-1 [pii]
AID - 10.1016/j.ijlp.2009.12.008 [doi]
PST - ppublish
SO  - Int J Law Psychiatry. 2010 Mar-Apr;33(2):84-8. doi: 10.1016/j.ijlp.2009.12.008.
      Epub 2010 Jan 3.


PMID- 20050785
OWN - NLM
STAT- MEDLINE
DCOM- 20100421
LR  - 20161018
IS  - 1557-900X (Electronic)
IS  - 0892-7790 (Linking)
VI  - 24
IP  - 2
DP  - 2010 Feb
TI  - Comparison of holding strength of suture anchors on human renal capsule.
PG  - 293-7
LID - 10.1089/end.2009.0211 [doi]
AB  - INTRODUCTION: The use of surgical clips as suture anchors has made laparoscopic
      partial nephrectomy (LPN) technically simpler by eliminating the need for
      intracorporeal knot tying. However, the holding strength of these clips has not
      been analyzed in the human kidney. Therefore, the safety of utilizing suture
      anchors is unknown as the potential for clip slippage or renal capsular tears
      during LPN could result in postoperative complications including hemorrhage and
      urinoma formation. With the above in mind, we sought to compare the ability of
      Lapra-Ty clips and Hem-o-lok clips to function as suture anchors on human renal
      capsule. METHODS: Fresh human cadaveric kidneys with intact renal capsules were
      obtained. A Lapra-Ty clip (Ethicon, Cincinnati, OH) or a Hem-o-lok clip (Weck,
      Raleigh, NC) was secured to a no. 1 Vicryl suture (Ethicon) with and without a
      knot, as is typically utilized during the performance of LPN. The suture was then
      placed through the renal capsule and parenchyma and attached to an Imada
      Mechanical Force Tester (Imada, Northbrook, IL). The amount of force required
      both to violate the renal capsule and to dislodge the clip was recorded
      separately. RESULTS: Six Lapra-Ty clips and six Hem-o-lok clips were tested. The 
      mean force in newtons required to violate the renal capsule for the Lapra-Ty
      group was 7.33 N and for the Hem-o-lok group was 22.08 N (p < 0.001). The mean
      force required to dislodge the clip from the suture for the Lapra-Ty group was
      9.0 N and for the Hem-o-lok group was 3.4 N (p < 0.001). When two Hem-o-lok clips
      were placed on the suture in series, the mean force required to dislodge the
      clips was 10.6 N. CONCLUSION: When compared with Lapra-Ty clips, using two
      Hem-o-lok clips may provide a more secure and cost-effective method to anchor
      sutures on human renal capsule when performing LPN.
FAU - Tarin, Tatum
AU  - Tarin T
AD  - Department of Urology, Stanford University Medical Center, Palo Alto, California 
      94304, USA. skimm@stanford.edu
FAU - Kimm, Simon
AU  - Kimm S
FAU - Chung, Benjamin
AU  - Chung B
FAU - Shinghal, Rajesh
AU  - Shinghal R
FAU - Reese, Jeffrey
AU  - Reese J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Endourol
JT  - Journal of endourology
JID - 8807503
SB  - IM
EIN - J Endourol. 2010 Apr;24(4):649
MH  - Humans
MH  - Kidney/*physiology
MH  - Nephrectomy
MH  - Surgical Instruments
MH  - *Suture Anchors
MH  - *Tensile Strength
EDAT- 2010/01/07 06:00
MHDA- 2010/04/22 06:00
CRDT- 2010/01/07 06:00
PHST- 2010/01/07 06:00 [entrez]
PHST- 2010/01/07 06:00 [pubmed]
PHST- 2010/04/22 06:00 [medline]
AID - 10.1089/end.2009.0211 [doi]
PST - ppublish
SO  - J Endourol. 2010 Feb;24(2):293-7. doi: 10.1089/end.2009.0211.


PMID- 20049938
OWN - NLM
STAT- MEDLINE
DCOM- 20100329
LR  - 20191210
IS  - 1520-6394 (Electronic)
IS  - 1091-4269 (Linking)
VI  - 27
IP  - 1
DP  - 2010
TI  - Diversity of effective treatments of panic attacks: what do they have in common?
PG  - 5-11
LID - 10.1002/da.20601 [doi]
AB  - By comparing efficacious psychological therapies of different kinds, inferences
      about common effective treatment mechanisms can be made. We selected six
      therapies for review on the basis of the diversity of their theoretical
      rationales and evidence for superior efficacy: psychoanalytic psychotherapy,
      hypercapnic breathing training, hypocapnic breathing training, reprocessing with 
      and without eye-movement desensitization, muscle relaxation, and cognitive
      behavior therapy. The likely common element of all these therapies is that they
      reduce the immediate expectancy of a panic attack, disrupting the vicious circle 
      of fearing fear. Modifying expectation is usually regarded as a placebo mechanism
      in psychotherapy, but may be a specific treatment mechanism for panic. The fact
      that this is seldom the rationale communicated to the patient creates a moral
      dilemma: Is it ethical for therapists to mislead patients to help them? Pragmatic
      justification of a successful practice is a way out of this dilemma. Therapies
      should be evaluated that deal with expectations directly by promoting positive
      thinking or by fostering non-expectancy.
FAU - Roth, Walton T
AU  - Roth WT
AD  - Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, 
      California, USA. wtroth@stanford.edu
LA  - eng
GR  - MH066953-01/MH/NIMH NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
PL  - United States
TA  - Depress Anxiety
JT  - Depression and anxiety
JID - 9708816
RN  - 142M471B3J (Carbon Dioxide)
SB  - IM
MH  - Arousal
MH  - Carbon Dioxide/blood
MH  - Cognitive Behavioral Therapy
MH  - Evidence-Based Medicine
MH  - Eye Movement Desensitization Reprocessing
MH  - Humans
MH  - Muscle Relaxation
MH  - Panic Disorder/psychology/*therapy
MH  - Placebo Effect
MH  - Psychoanalytic Therapy
MH  - Relaxation Therapy
MH  - Respiration
MH  - Set, Psychology
RF  - 46
EDAT- 2010/01/06 06:00
MHDA- 2010/03/30 06:00
CRDT- 2010/01/06 06:00
PHST- 2010/01/06 06:00 [entrez]
PHST- 2010/01/06 06:00 [pubmed]
PHST- 2010/03/30 06:00 [medline]
AID - 10.1002/da.20601 [doi]
PST - ppublish
SO  - Depress Anxiety. 2010;27(1):5-11. doi: 10.1002/da.20601.


PMID- 20049576
OWN - NLM
STAT- MEDLINE
DCOM- 20101103
LR  - 20131121
IS  - 1496-8975 (Electronic)
IS  - 0832-610X (Linking)
VI  - 57
IP  - 4
DP  - 2010 Apr
TI  - Rapid sequence induction for appendectomies: a retrospective case-review
      analysis.
PG  - 330-6
LID - 10.1007/s12630-009-9260-1 [doi]
AB  - PURPOSE: Rapid sequence induction (RSI) with cricoid pressure is suggested to
      decrease the risk of aspiration of gastric contents. However, the effectiveness
      of RSI has been questioned, and the technique may lead to airway and hemodynamic 
      complications. The purpose of this study was to determine the frequency of RSI
      use in patients with acute appendicitis, the types of drugs administered, and the
      occurrence of any complications. METHODS: After approval by the Ethics Committee,
      the charts of patients undergoing appendectomy in a one-year period were examined
      retrospectively. Information was retrieved on Mallampati airway evaluation,
      airway device used, preoxygenation, RSI, and drugs at induction. Reported
      complications were noted, including airway difficulties, hypotension (systolic
      blood pressure < 80 mmHg) and hypertension (>160 mmHg) in the 20-min period after
      induction. RESULTS: General anesthesia with tracheal intubation was used in 248
      of 250 cases reviewed. The Mallampati airway evaluation, preoxygenation, and RSI 
      were recorded as performed in 95, 94, and 81% of cases, respectively. Opioids,
      propofol, and neuromuscular blocking agents were given in 98, 98, and 99% of
      patients, respectively. Succinylcholine use was common (80%), with 96% of these
      patients receiving rocuronium precurarization. Difficult intubation with
      successful alternate technique was encountered in three patients (1.2%).
      Hypotension and hypertension occurred in 27% and 8% of patients, respectively.
      There were no documented cases of aspiration. Oxygen desaturation was mentioned
      in one case at induction and in three cases at emergence. CONCLUSION: An RSI with
      opioid, induction agent, and succinylcholine is the technique of choice for
      appendectomies at our institution. The frequency of airway complications is too
      low to recommend a change in practice.
FAU - Istvan, Juraj
AU  - Istvan J
AD  - Departement d'Anesthesiologie, Hopital Maisonneuve-Rosemont, Universite de
      Montreal, Montreal, Quebec, Canada. jristvan@gmail.com
FAU - Belliveau, Marc
AU  - Belliveau M
FAU - Donati, Francois
AU  - Donati F
LA  - eng
PT  - Journal Article
DEP - 20100105
PL  - United States
TA  - Can J Anaesth
JT  - Canadian journal of anaesthesia = Journal canadien d'anesthesie
JID - 8701709
RN  - S88TT14065 (Oxygen)
SB  - IM
CIN - Can J Anaesth. 2010 May;57(5):515-6; author reply 516. PMID: 20186510
MH  - Adult
MH  - Anesthesia, General/adverse effects/*methods
MH  - Appendectomy/*methods
MH  - Clinical Protocols
MH  - Female
MH  - Humans
MH  - Hypertension/etiology
MH  - Hypotension/etiology
MH  - Intubation, Intratracheal/adverse effects/*methods
MH  - Male
MH  - Oxygen/blood
MH  - Retrospective Studies
MH  - Treatment Outcome
EDAT- 2010/01/06 06:00
MHDA- 2010/11/04 06:00
CRDT- 2010/01/06 06:00
PHST- 2009/08/18 00:00 [received]
PHST- 2009/12/18 00:00 [accepted]
PHST- 2010/01/06 06:00 [entrez]
PHST- 2010/01/06 06:00 [pubmed]
PHST- 2010/11/04 06:00 [medline]
AID - 10.1007/s12630-009-9260-1 [doi]
PST - ppublish
SO  - Can J Anaesth. 2010 Apr;57(4):330-6. doi: 10.1007/s12630-009-9260-1. Epub 2010
      Jan 5.


PMID- 20049538
OWN - NLM
STAT- MEDLINE
DCOM- 20111130
LR  - 20211020
IS  - 1573-3394 (Electronic)
IS  - 1065-3058 (Linking)
VI  - 18
IP  - 4
DP  - 2010 Dec
TI  - The ethics of health barriers to immigration: morality among neighbours.
PG  - 342-57
LID - 10.1007/s10728-009-0142-z [doi]
AB  - Many countries encourage immigration, yet almost without exception they impose
      medical conditions on the admissibility of prospective immigrants. This paper
      examines the ethical defensibility of this practice. It argues that the
      neighbourhood principle, which states that we owe a greater duty to neighbours
      than to strangers, when properly understood, extends to all human beings, that
      economic and safety considerations play only a limited role in ethically
      underwriting an exclusionary policy, and that medical immigration criteria should
      be harmonized with treatment eligibility criteria for citizens of the relevant
      countries themselves.
FAU - Kluge, Eike-Henner W
AU  - Kluge EH
AD  - Department of Philosophy, University of Victoria, Victoria, BC, Canada.
      ekluge@uvic.ca
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Health Care Anal
JT  - Health care analysis : HCA : journal of health philosophy and policy
JID - 9432537
MH  - Eligibility Determination
MH  - *Emigration and Immigration
MH  - Health/*ethics
MH  - Health Status
MH  - Humans
MH  - Morals
MH  - Public Policy
MH  - *Transients and Migrants
EDAT- 2010/01/06 06:00
MHDA- 2011/12/13 00:00
CRDT- 2010/01/06 06:00
PHST- 2010/01/06 06:00 [entrez]
PHST- 2010/01/06 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/s10728-009-0142-z [doi]
PST - ppublish
SO  - Health Care Anal. 2010 Dec;18(4):342-57. doi: 10.1007/s10728-009-0142-z.


PMID- 20047556
OWN - NLM
STAT- MEDLINE
DCOM- 20100223
LR  - 20210116
IS  - 0025-729X (Print)
IS  - 0025-729X (Linking)
VI  - 192
IP  - 1
DP  - 2010 Jan 4
TI  - "Through a glass, darkly": the clinical and ethical implications of Munchausen
      syndrome. Comment.
PG  - 55
FAU - Dewitt, Dawn E
AU  - Dewitt DE
FAU - Bhat, Ravi
AU  - Bhat R
FAU - Ward, Stephanie
AU  - Ward S
LA  - eng
PT  - Comment
PT  - Letter
PL  - Australia
TA  - Med J Aust
JT  - The Medical journal of Australia
JID - 0400714
SB  - IM
CON - Med J Aust. 2009 Aug 17;191(4):217-9. PMID: 19705983
MH  - Australia
MH  - Confidentiality/*ethics
MH  - *Electronic Health Records/economics/standards
MH  - *Ethics, Medical
MH  - Factitious Disorders/diagnosis/economics
MH  - Humans
MH  - Munchausen Syndrome/*diagnosis/economics
MH  - Patient Rights/*ethics
MH  - Physician-Patient Relations
EDAT- 2010/01/06 06:00
MHDA- 2010/02/24 06:00
CRDT- 2010/01/06 06:00
PHST- 2009/09/07 00:00 [received]
PHST- 2009/09/14 00:00 [accepted]
PHST- 2010/01/06 06:00 [entrez]
PHST- 2010/01/06 06:00 [pubmed]
PHST- 2010/02/24 06:00 [medline]
AID - letters_040110_fm-5 [pii]
AID - 10.5694/j.1326-5377.2010.tb03411.x [doi]
PST - ppublish
SO  - Med J Aust. 2010 Jan 4;192(1):55. doi: 10.5694/j.1326-5377.2010.tb03411.x.


PMID- 20046172
OWN - NLM
STAT- MEDLINE
DCOM- 20110217
LR  - 20161020
IS  - 1022-4742 (Print)
IS  - 1022-4742 (Linking)
VI  - 19
IP  - 1
DP  - 2010 Jan
TI  - Ethical issues in surgical intervention in medical college hospitals.
PG  - 54-9
AB  - The aim of this study was to investigate the ethical issues of the patients
      selected for surgical interventions. A total of 105 patients were selected
      consecutively on the basis of defined criteria at the Department of Surgery and
      the Department of Gynecology & Obstetrics of Sir Salimullah Medical College
      Mitford Hospital, Dhaka from March 2007 to November 2007. Results showed that
      76.19% of the patients were found to be literate and 23.81% were illiterate. In
      profession, 53.34% of the patients were found to be involved in household works, 
      16.19% were service holders, 12.38% were businessmen, 9.52% were cultivators,
      5.71% were students and the rest were day laborers. Nearly 60.0% of the patients 
      had no monthly income. Most of the patients were adults of age ranges from 16-70 
      years. Results about ethical issues showed that 52.38% of the patients had no
      knowledge about surgical treatment of their diseases prior to operation, 26.67%
      had poor knowledge and 20.95% had sufficient knowledge. Adequate counseling
      earlier to surgical intervention were ensured for 11.43% (n=12) patients only.
      Rest of the patients (88.57%) was not experienced counseling before operation.
      Nearly 81.0% of the patients did not understand about their treatment by surgical
      intervention. About 94.0% of the patients and their close relatives had no
      knowledge about informed consent and its importance as well as procedure of
      obtains but they sign it just before operation. Around 91.0% of the informed
      consents were not taken in presence of any witness. In postoperative counseling, 
      88.57% of the patients had not counseled. Nearly 66.0% of the patients did not
      satisfy about their treatment. In conclusion, truth-telling through counseling
      and informed consent were not found to be exercised properly in most of the
      patients undergoing surgical interventions in medical college hospitals.
FAU - Mannan, M A
AU  - Mannan MA
AD  - Department of Endocrinology, Dhaka Medical College, Dhaka, Bangladesh.
FAU - Hossain, K J
AU  - Hossain KJ
FAU - Bhuiya, A H
AU  - Bhuiya AH
LA  - eng
PT  - Journal Article
PL  - Bangladesh
TA  - Mymensingh Med J
JT  - Mymensingh medical journal : MMJ
JID - 9601799
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Bangladesh
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Female
MH  - Hospitals, University/*ethics
MH  - Humans
MH  - Informed Consent/ethics
MH  - Male
MH  - Middle Aged
MH  - Patient Selection/ethics
MH  - Socioeconomic Factors
MH  - Surgical Procedures, Operative/*ethics
MH  - Young Adult
EDAT- 2010/01/05 06:00
MHDA- 2011/02/18 06:00
CRDT- 2010/01/05 06:00
PHST- 2010/01/05 06:00 [entrez]
PHST- 2010/01/05 06:00 [pubmed]
PHST- 2011/02/18 06:00 [medline]
PST - ppublish
SO  - Mymensingh Med J. 2010 Jan;19(1):54-9.


PMID- 20045830
OWN - NLM
STAT- MEDLINE
DCOM- 20100414
LR  - 20190709
IS  - 1943-4723 (Electronic)
IS  - 0002-8177 (Linking)
VI  - 141
IP  - 1
DP  - 2010 Jan
TI  - Is it ethical to claim full credit for an on-site continuing education course
      that the presenter shortens significantly?
PG  - 99-101
FAU - Lantz, Marilyn S
AU  - Lantz MS
AD  - School of Dentistry, University of Michigan, AnnArbor, Michigan, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Am Dent Assoc
JT  - Journal of the American Dental Association (1939)
JID - 7503060
SB  - IM
MH  - American Dental Association
MH  - Education, Dental, Continuing/*ethics/standards
MH  - *Ethics, Professional
MH  - Humans
MH  - United States
EDAT- 2010/01/05 06:00
MHDA- 2010/04/15 06:00
CRDT- 2010/01/05 06:00
PHST- 2010/01/05 06:00 [entrez]
PHST- 2010/01/05 06:00 [pubmed]
PHST- 2010/04/15 06:00 [medline]
AID - S0002-8177(14)62224-8 [pii]
AID - 10.14219/jada.archive.2010.0029 [doi]
PST - ppublish
SO  - J Am Dent Assoc. 2010 Jan;141(1):99-101. doi: 10.14219/jada.archive.2010.0029.


PMID- 20044409
OWN - NLM
STAT- MEDLINE
DCOM- 20100402
LR  - 20170304
IS  - 1557-9700 (Electronic)
IS  - 1075-2730 (Linking)
VI  - 61
IP  - 1
DP  - 2010 Jan
TI  - Referral for medical evaluation: an ethical obligation?
PG  - 3
LID - 10.1176/appi.ps.61.1.3 [doi]
FAU - Grace, Glenn D
AU  - Grace GD
FAU - Christensen, Richard C
AU  - Christensen RC
LA  - eng
PT  - Editorial
PL  - United States
TA  - Psychiatr Serv
JT  - Psychiatric services (Washington, D.C.)
JID - 9502838
SB  - IM
MH  - *Clinical Medicine
MH  - Humans
MH  - *Moral Obligations
MH  - Psychiatry/ethics
MH  - Referral and Consultation/*ethics
EDAT- 2010/01/02 06:00
MHDA- 2010/04/03 06:00
CRDT- 2010/01/02 06:00
PHST- 2010/01/02 06:00 [entrez]
PHST- 2010/01/02 06:00 [pubmed]
PHST- 2010/04/03 06:00 [medline]
AID - 61/1/3 [pii]
AID - 10.1176/ps.2010.61.1.3 [doi]
PST - ppublish
SO  - Psychiatr Serv. 2010 Jan;61(1):3. doi: 10.1176/ps.2010.61.1.3.


PMID- 20043663
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20100916
LR  - 20100615
IS  - 1520-4898 (Electronic)
IS  - 0001-4842 (Linking)
VI  - 43
IP  - 6
DP  - 2010 Jun 15
TI  - Structural examination of easel paintings with optical coherence tomography.
PG  - 826-36
LID - 10.1021/ar900195d [doi]
AB  - Identification of the order, thickness, composition, and possibly the origin of
      the paint layers forming the structure of a painting, that is, its stratigraphy, 
      is important in confirming its attribution and history as well as planning
      conservation treatments. The most common method of examination is analysis of a
      sample collected from the art object, both visually with a microscope and
      instrumentally through a variety of sophisticated, modern analytical tools.
      Because of its invasiveness, however, sampling is less than ideally compatible
      with conservation ethics; it is severely restricted with respect to the amount of
      material extirpated from the artwork. Sampling is also rather limited in that it 
      provides only very local information. There is, therefore, a great need for a
      noninvasive method with sufficient in-depth resolution for resolving the
      stratigraphy of works of art. Optical coherence tomography (OCT) is a
      noninvasive, noncontact method of optical sectioning of partially transparent
      objects, with micrometer-level axial resolution. The method utilizes
      near-infrared light of low intensity (a few milliwatts) to obtain cross-sectional
      images of various objects; it has been mostly used in medical diagnostics.
      Through the serial collection of many such images, volume information may be
      extracted. The application of OCT to the examination of art objects has been in
      development since 2003. In this Account, we present a short introduction to the
      technique, briefly discuss the apparatus we use, and provide a paradigm for
      reading OCT tomograms. Unlike the majority of papers published previously, this
      Account focuses on one, very specific, use of OCT. We then consider two examples 
      of successful, practical application of the technique. At the request of a
      conservation studio, the characteristics of inscriptions on two oil paintings,
      originating from the 18th and 19th centuries, were analyzed. In the first case,
      it was possible to resolve some questions concerning the history of the work.
      From an analysis of the positions of the paint layers involved in three
      inscriptions in relation to other strata of the painting, the order of events in 
      its history was resolved. It was evident that the original text had been
      overpainted and that the other inscriptions were added later, thus providing
      convincing evidence as to the painting's true date of creation. In the second
      example, a painting was analyzed with the aim of confirming the possibility of
      forgery of the artist's signature, and evidence strongly supporting this
      supposition is presented. These two specific examples of successful use of the
      technique on paintings further demonstrate how OCT may be readily adaptable to
      other similar tasks, such as in the fields of forensic or materials science. In a
      synergistic approach, in which information is obtained with a variety of
      noninvasive techniques, OCT is demonstrably effective and offers great potential 
      for further development.
FAU - Targowski, Piotr
AU  - Targowski P
AD  - Institute of Physics, Nicolaus Copernicus University, ul. Grudziadzka 5, 87-100
      Torun, Poland.
FAU - Iwanicka, Magdalena
AU  - Iwanicka M
FAU - Tyminska-Widmer, Ludmila
AU  - Tyminska-Widmer L
FAU - Sylwestrzak, Marcin
AU  - Sylwestrzak M
FAU - Kwiatkowska, Ewa A
AU  - Kwiatkowska EA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Acc Chem Res
JT  - Accounts of chemical research
JID - 0157313
EDAT- 2010/01/02 06:00
MHDA- 2010/01/02 06:01
CRDT- 2010/01/02 06:00
PHST- 2010/01/02 06:00 [entrez]
PHST- 2010/01/02 06:00 [pubmed]
PHST- 2010/01/02 06:01 [medline]
AID - 10.1021/ar900195d [doi]
PST - ppublish
SO  - Acc Chem Res. 2010 Jun 15;43(6):826-36. doi: 10.1021/ar900195d.


PMID- 20042830
OWN - NLM
STAT- MEDLINE
DCOM- 20100126
LR  - 20091231
IS  - 1938-808X (Electronic)
IS  - 1040-2446 (Linking)
VI  - 85
IP  - 1
DP  - 2010 Jan
TI  - Perspective: Conflict of interest and professional organizations: considerations 
      and recommendations.
PG  - 85-91
LID - 10.1097/ACM.0b013e3181c46429 [doi]
AB  - There are differences in conflicts of interest (COIs) in professional
      organizations compared with academic medical centers. The authors discuss nine
      major questions pertaining to industry relationships of professional
      organizations: (1) What makes COI management different in professional membership
      organizations? (2) What COI challenges are specific to professional
      organizations? (3) What are potential impacts of perceived or real COIs involving
      professional organizations and the management of COIs? (4) Is regulation
      necessary, or should professional organizations proactively resolve COI issues
      independently? (5) Are guidelines portable from academic medical centers to
      professional organizations? (6) What approaches may be considered for managing
      COIs of the organization's leaders? (7) What approaches are reasonable for
      managing COI issues at professional meetings? (8) What approaches are important
      for integrity of educational programs, publications, and products? and (9) What
      approaches are reasonable for managing and enforcing COI guidelines on an ongoing
      basis? Responses to these questions focus on four principles: First, a code of
      ethics governing general behavior of members and safeguarding the interest of
      patients must be in place; second, the monitoring and management of COI for
      leadership, including, in some cases, recusal from certain activities; third, the
      pooling and consistent, transparent management of unrestricted grants from
      corporate sponsors; and, fourth, the management of industry marketing efforts at 
      membership meetings to ensure their appropriateness. The perspectives offered are
      intended to encourage individuals and learned bodies to further study and provide
      commentary and recommendations on managing COIs of a professional organization.
FAU - Camilleri, Michael
AU  - Camilleri M
AD  - Mayo Clinic, Rochester, Minnesota 55905, USA. camilleri.michael@mayo.edu
FAU - Parke, David W 2nd
AU  - Parke DW 2nd
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Acad Med
JT  - Academic medicine : journal of the Association of American Medical Colleges
JID - 8904605
SB  - IM
CIN - Acad Med. 2010 Jan;85(1):9-11. PMID: 20042812
MH  - American Medical Association
MH  - *Conflict of Interest
MH  - Drug Industry/*ethics
MH  - Hospitals, Teaching/*ethics
MH  - Humans
MH  - Organizational Policy
MH  - Societies, Medical/*ethics
MH  - Teaching/*ethics
MH  - United States
RF  - 23
EDAT- 2010/01/01 06:00
MHDA- 2010/01/27 06:00
CRDT- 2010/01/01 06:00
PHST- 2010/01/01 06:00 [entrez]
PHST- 2010/01/01 06:00 [pubmed]
PHST- 2010/01/27 06:00 [medline]
AID - 10.1097/ACM.0b013e3181c46429 [doi]
AID - 00001888-201001000-00027 [pii]
PST - ppublish
SO  - Acad Med. 2010 Jan;85(1):85-91. doi: 10.1097/ACM.0b013e3181c46429.


PMID- 20042477
OWN - NLM
STAT- MEDLINE
DCOM- 20100225
LR  - 20220409
IS  - 1471-6771 (Electronic)
IS  - 0007-0912 (Linking)
VI  - 104
IP  - 2
DP  - 2010 Feb
TI  - Comparison of early cognitive function and recovery after desflurane or
      sevoflurane anaesthesia in the elderly: a double-blinded randomized controlled
      trial.
PG  - 167-74
LID - 10.1093/bja/aep369 [doi]
AB  - BACKGROUND: Postoperative cognitive dysfunction (POCD) is being recognized as a
      complication contributing to perioperative morbidity and mortality of the
      elderly. We hypothesized that the use of the shorter-acting volatile anaesthetic 
      desflurane would be associated with less incidence of POCD when compared with
      sevoflurane. METHODS: Approved by the local ethical committee, 80 patients (aged 
      65-75 yr) were enrolled in this randomized, double-blinded study. Patients were
      allocated to either the desflurane (n=40) or the sevoflurane (n=40) group. The
      primary outcome was the cognitive Test for Attentional Performance with its
      subtests Alertness, Divided Attention, Visual Scanning, Working Memory, and
      Reaction Change. In addition, Paper-Pencil Tests [Well-being Test BF-S, Recall of
      Digit Span (DST), Digit-Symbol-Substitution Test, Trail Making Tests A and B, and
      Spielberg State-Trait Anxiety Inventory] were measured. After baseline assessment
      12-24 h before operation, patients were followed up 6-8 and 66-72 h after
      operation. Among other outcome parameters, emergence times from anaesthesia and
      modified Aldrete scores were recorded. RESULTS: There was no difference in the
      incidence of POCD. However, according to the Paper-Pencil Tests, significant
      improvements for the desflurane group could be detected (Well-being Test at 6-8
      h, DST at 6-8 h, and Trail Making Test at 66-72 h). Emergence was significantly
      faster in the desflurane group for 'time to open eyes' and 'time to extubation'. 
      CONCLUSIONS: The total incidence of POCD showed no differences between the
      desflurane and the sevoflurane groups. However, the tests Well-being scale, DST, 
      and Trail Making Test, emergence times, and patients' satisfaction were in favour
      of desflurane.
FAU - Rortgen, D
AU  - Rortgen D
AD  - Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen,
      Pauwelsstreet 30, D-52072 Aachen, Germany.
FAU - Kloos, J
AU  - Kloos J
FAU - Fries, M
AU  - Fries M
FAU - Grottke, O
AU  - Grottke O
FAU - Rex, S
AU  - Rex S
FAU - Rossaint, R
AU  - Rossaint R
FAU - Coburn, M
AU  - Coburn M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20091230
PL  - England
TA  - Br J Anaesth
JT  - British journal of anaesthesia
JID - 0372541
RN  - 0 (Anesthetics, Inhalation)
RN  - 0 (Methyl Ethers)
RN  - 38LVP0K73A (Sevoflurane)
RN  - CRS35BZ94Q (Desflurane)
RN  - CYS9AKD70P (Isoflurane)
SB  - IM
MH  - Aged
MH  - Anesthesia Recovery Period
MH  - Anesthetics, Inhalation/*adverse effects
MH  - Cognition Disorders/*chemically induced
MH  - Desflurane
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Isoflurane/adverse effects/*analogs & derivatives
MH  - Male
MH  - Methyl Ethers/*adverse effects
MH  - Neuropsychological Tests
MH  - Patient Satisfaction
MH  - Postoperative Complications/*chemically induced
MH  - Sevoflurane
EDAT- 2010/01/01 06:00
MHDA- 2010/02/26 06:00
CRDT- 2010/01/01 06:00
PHST- 2010/01/01 06:00 [entrez]
PHST- 2010/01/01 06:00 [pubmed]
PHST- 2010/02/26 06:00 [medline]
AID - S0007-0912(17)34626-3 [pii]
AID - 10.1093/bja/aep369 [doi]
PST - ppublish
SO  - Br J Anaesth. 2010 Feb;104(2):167-74. doi: 10.1093/bja/aep369. Epub 2009 Dec 30.


PMID- 20041861
OWN - NLM
STAT- MEDLINE
DCOM- 20101012
LR  - 20141120
IS  - 1600-6143 (Electronic)
IS  - 1600-6135 (Linking)
VI  - 10
IP  - 3
DP  - 2010 Mar
TI  - In response to: Testa et al. 'Elective surgical patients as living organ donors: 
      a clinical and ethical innovation'.
PG  - 704-5; author reply 706
LID - 10.1111/j.1600-6143.2009.02946.x [doi]
FAU - Gordon, E J
AU  - Gordon EJ
FAU - Frader, J
AU  - Frader J
FAU - Goldberg, A M
AU  - Goldberg AM
FAU - Penrod, D
AU  - Penrod D
FAU - McNatt, G
AU  - McNatt G
FAU - Franklin, J
AU  - Franklin J
CN  - Chicago Transplant Ethics Consortium
LA  - eng
PT  - Comment
PT  - Letter
DEP - 20091223
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
SB  - IM
CON - Am J Transplant. 2009 Oct;9(10):2400-5. PMID: 19663888
MH  - Cholecystectomy/methods
MH  - Coercion
MH  - Elective Surgical Procedures
MH  - Ethics, Medical
MH  - Female
MH  - Humans
MH  - Kidney Transplantation
MH  - *Living Donors
MH  - Male
MH  - Trust
EDAT- 2010/01/01 06:00
MHDA- 2010/10/13 06:00
CRDT- 2010/01/01 06:00
PHST- 2010/01/01 06:00 [entrez]
PHST- 2010/01/01 06:00 [pubmed]
PHST- 2010/10/13 06:00 [medline]
AID - AJT2946 [pii]
AID - 10.1111/j.1600-6143.2009.02946.x [doi]
PST - ppublish
SO  - Am J Transplant. 2010 Mar;10(3):704-5; author reply 706. doi:
      10.1111/j.1600-6143.2009.02946.x. Epub 2009 Dec 23.


PMID- 20041827
OWN - NLM
STAT- MEDLINE
DCOM- 20100625
LR  - 20211008
IS  - 1873-4286 (Electronic)
IS  - 1381-6128 (Linking)
VI  - 16
IP  - 8
DP  - 2010
TI  - Splice modification to restore functional dystrophin synthesis in Duchenne
      muscular dystrophy.
PG  - 988-1001
AB  - In little more than a decade, induced exon skipping as a therapy to treat
      Duchenne muscular dystrophy (DMD) has progressed from a concept tested in vitro, 
      to pre-clinical evaluation in mouse and dog models, and recent completion of
      Phase I clinical trials in man. There is no longer any doubt that antisense
      oligomers can redirect dystrophin gene processing and by-pass protein truncating 
      mutations after direct injection into muscle. Proof-of-concept has been
      demonstrated in human dystrophic muscle, with trials in Leiden and London showing
      that two different oligomer chemistries can restore the reading-frame in selected
      DMD patients by excising dystrophin exon 51. Systemic delivery of both oligomer
      types into DMD patients has commenced with promising results but it remains to be
      established if this therapy will have measurable clinical benefits. Targeted
      removal of exon 51 will only be directly applicable to about one in ten DMD
      individuals, and the immediate challenges include development of appropriate and 
      effective delivery regimens, and extending splice-switching therapies to other
      dystrophin gene lesions. The success of induced exon skipping has spawned a
      number of "fusion therapies", including vector-mediated dystrophin exon skipping 
      and ex vivo viral delivery of splice-switching antisense molecules into myogenic 
      stem cells, followed by implantation, which may address long term oligomer
      delivery issues. This review summarizes the pivotal events leading to the
      completion of the first proof-of-concept trials and speculates on some of the
      scientific, ethical, regulatory and commercial challenges facing targeted exon
      skipping for the treatment of DMD.
FAU - Wilton, Steve D
AU  - Wilton SD
AD  - Centre for Neuromuscular and Neurological Disorders, University of Western
      Australia, 4th Floor A Block, QE II Medical Centre, Nedlands, Western Australia, 
      Australia. swilton@meddent.uwa.edu.au
FAU - Fletcher, Susan
AU  - Fletcher S
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Curr Pharm Des
JT  - Current pharmaceutical design
JID - 9602487
RN  - 0 (Dystrophin)
RN  - 0 (Oligonucleotides, Antisense)
SB  - IM
MH  - Animals
MH  - Clinical Trials as Topic
MH  - Dystrophin/*genetics
MH  - Exons/drug effects/genetics
MH  - Gene Deletion
MH  - Genetic Therapy/*methods
MH  - Humans
MH  - Muscular Dystrophy, Animal/genetics/therapy
MH  - Muscular Dystrophy, Duchenne/genetics/*therapy
MH  - Oligonucleotides, Antisense/economics/*therapeutic use
MH  - Stem Cell Transplantation/methods
RF  - 117
EDAT- 2010/01/01 06:00
MHDA- 2010/06/26 06:00
CRDT- 2010/01/01 06:00
PHST- 2009/11/17 00:00 [received]
PHST- 2009/12/12 00:00 [accepted]
PHST- 2010/01/01 06:00 [entrez]
PHST- 2010/01/01 06:00 [pubmed]
PHST- 2010/06/26 06:00 [medline]
AID - BSP/CPD/E-Pub/00016 [pii]
AID - 10.2174/138161210790883480 [doi]
PST - ppublish
SO  - Curr Pharm Des. 2010;16(8):988-1001. doi: 10.2174/138161210790883480.


PMID- 30027726
OWN - HSR
STAT- MEDLINE
DCOM- 20180906
LR  - 20191210
IS  - 1066-1271 (Print)
IS  - 1066-1271 (Linking)
VI  - 63
IP  - 4
DP  - 2010
TI  - From Research Conclusions to Real Change: Understanding the First Amendment's
      (Non)Response to the Negative Effects of Media on Children by Looking to the
      Example of Violent Video Game Regulations.
PG  - 1197-1236
AB  - Through the careful examination of a case taken up by the U.S. Supreme Court
      during the 2010 Term, Schwarzenegger v. Entertainment Merchants Ass'n, this
      article assesses a new perspective on the issue of regulating children's access
      to mass media. The dominant influence of mass media on children is recognized by 
      experts across many disciplines, including child development, communication
      theory, psychology, sociology, and medicine. Numerous studies demonstrate
      potential harm to children from exposure to mass media and marketing sources.
      Nevertheless, courts have been reluctant to recognize such consequences,
      primarily on the basis of First Amendment and free speech concerns. Indeed, in a 
      significant line of cases the courts have invalidated every legislative effort to
      regulate children's access to violent video games. This legal reluctance presents
      a major barrier to the real world application of and benefit from research
      conclusions regarding the impact of media violence and consumer culture on
      children. While research of this nature has supported attempts at industry
      self-regulation or voluntary compliance with ethical guidelines, such efforts
      have achieved little success. The disconnect between law and social science has
      led scholars like Professor Barbara Bennett Woodhouse to propose a reframing of
      the issues. She calls for a paradigm shift from family law's traditional approach
      of the parent-child-state triangle to recognize the influence of what she terms
      "mass-media marketing." She proposes a new "child-centered approach to
      environmental ethics," or in her words "ecogenerism," and suggests that those who
      advocate for protection of children from the harms of mass media and marketing
      have much to learn from the environmental law and ethics movement. Woodhouse's
      proposal offers an appealing perspective for those who support regulation of
      children's access to harmful media. The real issue, however, is whether
      ecogenerism will evolve from academic theory to actual practice. This article
      tests her theory by revisiting the line of violent video game cases to evaluate
      whether her ecogenerist perspective can achieve any real change in the courts'
      decisions. Particular attention is devoted to challenges presented by First
      Amendment free speech protections with a primary focus on the Ninth Circuit's
      decision in Schwarzenegger to invalidate a California statute prohibiting the
      sale or rental of violent video games to minors, a case that the Supreme Court is
      poised to soon decide. While some speculate that the Supreme Court is unlikely to
      reverse the Ninth Circuit's decision given the uniform position of other courts
      on this issue, this article reveals that an ecogenerist perspective demands a
      reversal by the Court precisely for that reason. Should the Court affirm the
      Ninth Circuit's invalidation of the statute, the article concludes by proposing
      recommendations for future research and regulatory efforts from an ecogenerist
      perspective.
FAU - Knake, Renee Newman
AU  - Knake RN
AD  - Michigan State University College of Law.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - SMU Law Rev
JT  - SMU law review : a publication of Southern Methodist University School of Law
JID - 100883492
MH  - Advertising/legislation & jurisprudence
MH  - Aggression
MH  - Child
MH  - Child Behavior
MH  - *Child Welfare
MH  - Civil Rights
MH  - Government Regulation
MH  - Humans
MH  - Mass Media/*legislation & jurisprudence
MH  - Social Control Policies/legislation & jurisprudence
MH  - Social Sciences
MH  - United States
MH  - Video Games/*adverse effects/legislation & jurisprudence
MH  - Violence/*legislation & jurisprudence
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2018/07/21 06:00
PHST- 2018/07/21 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
PST - ppublish
SO  - SMU Law Rev. 2010;63(4):1197-1236.


PMID- 29783366
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1744-828X (Electronic)
IS  - 1741-0541 (Linking)
VI  - 7
IP  - 1
DP  - 2010 Jan
TI  - Taking the patient's side: the ethics of pharmacogenetics.
PG  - 75-85
LID - 10.2217/pme.09.47 [doi]
AB  - From the perspective of current and future patients, the development of the field
      of pharmacogenetics is of immense interest. The encouraging vision that is now
      being established is that we may move from trial and error therapies to
      evidence-based personalized medicine in clinical practice. However, research and 
      the application of pharmacogenetics to clinical practice are believed to raise a 
      host of controversial ethical issues. Some of these are related to the research
      process, for example, confidentiality and informed consent in association with
      human tissue sampling. Other issues arise on a societal level, for example,
      issues regarding justice and the use of race or ethnicity as proxies for
      genotyping. In this perspective, I comment on this debate and also suggest what
      we may learn from previous discussions regarding DNA testing and gene transfer
      methods. Arguably, the most important ethical perspective in medical research and
      drug development is related to the interests of patients wanting medical
      treatment that is both effective and carries low risks of adverse effects.
      Risk:benefit ratios must always be compared with existing alternatives, and while
      the risk of adverse effects may be tolerable for some individuals, owing to
      genetic reasons, this may not be relevant for others. This will have consequences
      for regulatory policies regarding drug development. In the future, personalized
      medicine will also need to take epigenetic and environmental factors into
      consideration.
FAU - Hansson, Mats G
AU  - Hansson MG
AD  - Centre for Research Ethics & Bioethics, Department of Public Health and Caring
      Sciences, Uppsala University, PO Box 564, SE 75122, Uppsala, Sweden.
      mats.hansson@crb.uu.se.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Per Med
JT  - Personalized medicine
JID - 101238549
OTO - NOTNLM
OT  - bioethics
OT  - ethics
OT  - hype
OT  - informed consent
OT  - justice
OT  - personalized medicine
OT  - pharmacogenetics
OT  - race
OT  - risk management
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2018/05/23 06:00
PHST- 2018/05/23 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - 10.2217/pme.09.47 [doi]
PST - ppublish
SO  - Per Med. 2010 Jan;7(1):75-85. doi: 10.2217/pme.09.47.


PMID- 28757905
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1886-5887 (Print)
IS  - 1886-5887 (Linking)
VI  - 18
DP  - 2010 Jan
TI  - [The "weak and sensitive elements" of the pediatric and adolescents' clinical
      trials].
PG  - 26-30
AB  - The ethical review of clinical research on children and adolescents should be
      centered in aspects related to their condition of vulnerability, which is
      nurtured by biological, emotional, equity and justice elements.However, the
      suggested vision in this case, without overlooking previously mentioned
      characteristics, is the one that seeks to delve deeper in one of the actors of
      the research process: the clinical research protocol.The objective is to
      determine the presence or not of "fragile zones or weak spots" in its interior,
      that when individualized and considered, will contribute to improve the quality
      of the ethical review on children and adolescent research.
FAU - Melamed, Irene N
AU  - Melamed IN
LA  - spa
GR  - R25 TW001605/TW/FIC NIH HHS/United States
PT  - English Abstract
PT  - Journal Article
TT  - Los "puntos debiles o sensibles" de los Ensayos Clinicos en ninas/os y
      adolescentes.
PL  - Spain
TA  - Rev Bioet Derecho
JT  - Revista de bioetica y derecho
JID - 101316791
PMC - PMC5528859
MID - NIHMS873871
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2017/08/01 06:00
PHST- 2017/08/01 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
PST - ppublish
SO  - Rev Bioet Derecho. 2010 Jan;18:26-30.


PMID- 28156298
OWN - NLM
STAT- MEDLINE
DCOM- 20180405
LR  - 20181202
IS  - 1819-6357 (Electronic)
IS  - 1819-6357 (Linking)
VI  - 5
IP  - 1
DP  - 2010 Jan
TI  - 'Take me home and allow me to die peacefully' - an ethical dilemma of grave
      concern.
PG  - 4628
LID - 10.3402/ljm.v5i0.4628 [doi]
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Libyan J Med
JT  - The Libyan journal of medicine
JID - 101299403
SB  - IM
MH  - Humans
MH  - Terminal Care/*ethics
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2017/02/04 06:00
PHST- 2017/02/04 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - 10.3402/ljm.v5i0.4628 [doi]
PST - ppublish
SO  - Libyan J Med. 2010 Jan;5(1):4628. doi: 10.3402/ljm.v5i0.4628.


PMID- 27820359
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1838-2142 (Print)
IS  - 1838-2142 (Linking)
VI  - 8
IP  - 34 Suppl
DP  - 2010
TI  - Nurses' experiences of ethical preparedness for catastrophic public health
      emergencies and health care disasters; a systematic review of qualitative
      evidence.
PG  - 1-15
FAU - Johnstone, Megan-Jane
AU  - Johnstone MJ
AD  - 1Professor, School of Nursing and Midwifery, Deakin University (Burwood Campus)
      and the Deakin Centre for Quality and Risk Management in Healthcare: a JBI
      collaborating centre. Contact: megan.johnstone@deakin.edu.au Telephone: +61 3
      9244 6120 2 Professor, School of Medicine, Faculty of Health Sciences, Yamaguchi 
      University, Japan Contact: sturale@yamaguchi-u.ac.jp Telephone: +81 836 22 2132.
FAU - Turale, Sue
AU  - Turale S
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - JBI Libr Syst Rev
JT  - JBI library of systematic reviews
JID - 101688957
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2016/11/08 06:00
PHST- 2016/11/08 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - 01938924-201008341-00011 [pii]
AID - 10.11124/01938924-201008341-00011 [doi]
PST - ppublish
SO  - JBI Libr Syst Rev. 2010;8(34 Suppl):1-15. doi: 10.11124/01938924-201008341-00011.


PMID- 27147841
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160505
LR  - 20201001
IS  - 1179-1500 (Print)
IS  - 1179-1500 (Linking)
VI  - 2
DP  - 2010
TI  - The first 7 years of the metropolitan fire brigade emergency responder program - 
      an overview of incidents attended.
PG  - 77-82
LID - 10.2147/OAEM.S12541 [doi]
AB  - PURPOSE: The Melbourne Metropolitan Fire and Emergency Services Board (MFESB) was
      the first fire service in Australia to implement a service-wide emergency medical
      response (EMR) program in 2001. No additional scientific analysis of the first
      responder program has been reported since the pilot program. The objective of
      this study was to report the first 7 years of responses by firefighters as first 
      responders. PATIENTS AND METHODS: The MFESB have three separate datasets with
      cardiac arrest information: (i) callout record; (ii) patient care record; and
      (iii) cardiac arrest record, including data from the automatic external
      defibrillator. Descriptive statistics were used to summarize the demographic and 
      specific outcome data. Ethics approval was granted. RESULTS: A total of 8227
      incidents were attended over the first 7 years. The most incidents attended were 
      cardiac arrest 54% (n = 4450) followed by other medical 19% (n = 1579), and drug 
      overdose 11% (n = 908); the remainder were <10% each. Sixty-three percent of
      incidents involved males. Average age was 57.2 years, median age 63 years, range 
      from <1 month to 101 years; average response time was 6.1 minutes, median
      response time 5.6 minutes, range from 9 seconds to 31.5 minutes. Firefighters
      provided "initial care" in 57% and assisted in 26% of the incidents. Firefighters
      spent on average 4.8 minutes with the patient before handing over to paramedics; 
      median 3.9 minutes, range of a few seconds to 39.2 minutes. CONCLUSION: This
      study suggests that the MFESB EMR program is providing firefighter first
      responders to emergency situations in a short timeframe to assist the ambulance
      service.
FAU - Boyle, Malcolm J
AU  - Boyle MJ
AD  - Department of Community Emergency Health and Paramedic Practice, Monash
      University, Frankston, Victoria, Australia.
FAU - Williams, Brett
AU  - Williams B
AD  - Department of Community Emergency Health and Paramedic Practice, Monash
      University, Frankston, Victoria, Australia.
FAU - Bibby, Colin
AU  - Bibby C
AD  - Emergency Medical Services, Metropolitan Fire and Emergency Services Board,
      Richmond, Victoria, Australia.
FAU - Morton, Allan
AU  - Morton A
AD  - Emergency Medical Services, Metropolitan Fire and Emergency Services Board,
      Richmond, Victoria, Australia.
FAU - Huggins, Chris
AU  - Huggins C
AD  - Department of Community Emergency Health and Paramedic Practice, Monash
      University, Frankston, Victoria, Australia.
LA  - eng
PT  - Journal Article
DEP - 20101009
PL  - New Zealand
TA  - Open Access Emerg Med
JT  - Open access emergency medicine : OAEM
JID - 101570796
PMC - PMC4806830
OTO - NOTNLM
OT  - cardiac arrest
OT  - emergency medical services
OT  - fire department
OT  - first responder
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2016/05/06 06:00
PHST- 2016/05/06 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - 10.2147/OAEM.S12541 [doi]
AID - oaem-2-077 [pii]
PST - epublish
SO  - Open Access Emerg Med. 2010 Oct 9;2:77-82. doi: 10.2147/OAEM.S12541. eCollection 
      2010.


PMID- 26568667
OWN - NLM
STAT- Publisher
LR  - 20191120
IS  - 1050-8422 (Print)
IS  - 1050-8422 (Linking)
VI  - 20
IP  - 2
DP  - 2010
TI  - Decisional Capacity among Minors with HIV: A Model for Balancing Autonomy Rights 
      with the Need for Protection.
PG  - 83-94
AB  - The purpose of this paper is threefold: (1) to describe the relevant ethical and 
      legal issues associated with decisional capacity among minors and to discuss the 
      importance of these concepts for children and adolescents living with HIV; (2) to
      provide a framework for assessing the decisional capacity of children and
      adolescents with HIV; and (3) to present a model for thinking about how to use
      this assessment data to guide action along the protection-autonomy continuum.
FAU - Chenneville, Tiffany
AU  - Chenneville T
AD  - Department of Psychology, University of South Florida St. Petersburg, Florida,
      140 7 Avenue South, Davis Hall 258, St. Petersburg, Florida 33701. Office:
      727-873-4585; chennevi@mail.usf.edu.
FAU - Sibille, Kimberly
AU  - Sibille K
AD  - Comprehensive Center for Pain Research, University of Florida, P.O. Box 103628,
      Gainesville, Florida 32610-3628. Office: 352-273-5981; ksibille@ufl.edu.
FAU - Bendell-Estroff, Debra
AU  - Bendell-Estroff D
AD  - School of Psychology, Fielding Graduate University, 5342 Ballona Lane, Culver
      City, California 90230. Office: 310-308-3246; Dbestroff@mednet.ucla.edu.
LA  - eng
GR  - T32 NS045551/NS/NINDS NIH HHS/United States
PT  - Journal Article
DEP - 20100319
PL  - United States
TA  - Ethics Behav
JT  - Ethics & behavior
JID - 9102086
PMC - PMC4643318
MID - NIHMS722111
OTO - NOTNLM
OT  - AIDS
OT  - HIV
OT  - adolescents
OT  - assent
OT  - autonomy
OT  - children
OT  - competence
OT  - consent
OT  - decisional capacity
OT  - model
OT  - pediatric
OT  - protection
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:00
CRDT- 2015/11/17 06:00
PHST- 2015/11/17 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:00 [medline]
AID - 10.1080/10508421003595901 [doi]
PST - ppublish
SO  - Ethics Behav. 2010;20(2):83-94. doi: 10.1080/10508421003595901. Epub 2010 Mar 19.


PMID- 26486215
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151021
LR  - 20200930
IS  - 2076-2615 (Print)
IS  - 2076-2615 (Linking)
VI  - 1
IP  - 1
DP  - 2010 Dec 31
TI  - Challenges to the Development and Implementation of Public Policies to Achieve
      Animal Welfare Outcomes.
PG  - 69-82
LID - 10.3390/ani1010069 [doi]
AB  - Although there is a long-established tradition of concern for the welfare of
      animals, it was not until the mid 1800's that governments sought to enact
      legislation to protect animals from cruelty. In the 1950's, questions concerning 
      animal welfare re-emerged and in the ensuing years have been an on-going focus of
      government activities. These developments occurred against a backdrop of
      significant social change but there are important differences in what now
      underpins and informs these considerations. In the formulation and implementation
      of public policies, governments look for a course of action that represents and
      protects the interests of the community; the process may be challenging with
      competing interests but the final determination seeks a middle ground that best
      meets the needs and interests of the community as a whole. When policy
      development concerns our relationship with other animals, the complexity of this 
      relationship presents particular challenges not only to the formulation of
      policies but also to the evaluation of outcomes. Notably, the depth of feelings
      and diversity of views in our community reflect the complex social, cultural and 
      personal dimensions of this relationship. The use of animals for scientific
      purposes remains one of the most contentious animal welfare issues primarily
      because when animals are used for these purposes, accepted animal welfare
      benchmarks cannot always be met. Based on the Australian experience, this paper
      will discuss the influences in and on-going challenges to the development and
      implementation of public policy when animals are used for these purposes.
FAU - Rose, Margaret
AU  - Rose M
AD  - Prince of Wales Clinical School, University of New South Wales, Sydney,
      Australia. m.rose@unsw.edu.au.
LA  - eng
PT  - Journal Article
DEP - 20101231
PL  - Switzerland
TA  - Animals (Basel)
JT  - Animals : an open access journal from MDPI
JID - 101635614
PMC - PMC4552211
OTO - NOTNLM
OT  - animal ethics committees
OT  - animal research
OT  - animal welfare outcomes
OT  - legislation
OT  - public policy
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2015/10/22 06:00
PHST- 2010/12/22 00:00 [received]
PHST- 2010/12/31 00:00 [accepted]
PHST- 2015/10/22 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - ani1010069 [pii]
AID - 10.3390/ani1010069 [doi]
PST - epublish
SO  - Animals (Basel). 2010 Dec 31;1(1):69-82. doi: 10.3390/ani1010069.


PMID- 26486213
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151021
LR  - 20201001
IS  - 2076-2615 (Print)
IS  - 2076-2615 (Linking)
VI  - 1
IP  - 1
DP  - 2010 Dec 14
TI  - An Inclusive Re-Engagement with our Nonhuman Animal Kin: Considering Human
      Interrelationships with Nonhuman Animals.
PG  - 40-55
LID - 10.3390/ani1010040 [doi]
AB  - As humans increasingly acknowledge the effects that they are having on the
      planet, there is a realisation implicit in these effects that human
      interrelationships with nature are actually arbitrated and expedited
      exploitatively. Understanding how the different discourses and histories through 
      which the interrelationships with nature are mediated and actually told and then 
      retold is fundamental to appreciating how humans may relate with nature less
      exploitatively and in ways that are more inclusionary, particularly with nonhuman
      animals. Humans perceive nature and individual nonhuman animals in various ways. 
      This paper provides an investigation of how humans have socially constructed
      nature and their place as either within or outside of it. Such constructions are 
      elaborated conceptually and through narrative. More pertinently, this paper
      examines how nature and nonhuman animals are perceived and placed within those
      narratives that humans construct from reality. It is stressed here that such
      constructions have, and may continue, to lead to a worsening of the effects that 
      humans have on the planet if there is no acceptance or recognition that certain
      realities exist beyond the exploitative bounds of any human-inspired concept or
      narrative. This paper therefore provides the groundwork for the foundations of an
      ethic that is both socially and ecologically inclusive and is based on a soft
      realist approach.
FAU - Bennison, Rod
AU  - Bennison R
AD  - Honorary Fellow, Macquarie University, Sydney, Australia. ozrodoz@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20101214
PL  - Switzerland
TA  - Animals (Basel)
JT  - Animals : an open access journal from MDPI
JID - 101635614
PMC - PMC4552215
OTO - NOTNLM
OT  - animal
OT  - ecological
OT  - inclusion
OT  - nonhuman animal
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2015/10/22 06:00
PHST- 2010/11/19 00:00 [received]
PHST- 2010/12/09 00:00 [accepted]
PHST- 2015/10/22 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - ani1010040 [pii]
AID - 10.3390/ani1010040 [doi]
PST - epublish
SO  - Animals (Basel). 2010 Dec 14;1(1):40-55. doi: 10.3390/ani1010040.


PMID- 26113806
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1614-4864 (Print)
IS  - 1614-4864 (Linking)
VI  - 7
IP  - 4
DP  - 2010
TI  - "Jeder Mensch hat einen Name": Legal and Ethical Dimensions of Human Experiments 
      under National Socialism.
PG  - 255-260
AB  - This paper considers whether it is right to identify by name victims of
      experiments abused either for psychiatric research, or for other types of
      experimentation in psychiatric hospitals and institutions. Similar questions
      arise as to whether it is possible to identify any of the persons for whom brains
      and other body parts were held for medical research and teaching.
LA  - eng
GR  - 082808/Wellcome Trust/United Kingdom
PT  - Journal Article
PL  - Germany
TA  - Psychiatrie (Stuttg)
JT  - Psychiatrie (Stuttgart, Germany)
JID - 101233816
PMC - PMC4477039
MID - EMS63702
OTO - NOTNLM
OT  - Carl Schneider
OT  - Human experimentation
OT  - National Socialist medicine
OT  - "Aktion T4"
OT  - "Euthanasia"
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2015/06/27 06:00
PHST- 2015/06/27 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
PST - ppublish
SO  - Psychiatrie (Stuttg). 2010;7(4):255-260.


PMID- 25606206
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150121
LR  - 20201001
IS  - 1985-207X (Print)
IS  - 1985-2274 (Linking)
VI  - 5
IP  - 3
DP  - 2010
TI  - An 80-year-old woman with left shoulder pain.
PG  - 139-44
AB  - This case history illustrates the real life experience and dilemma of an
      80-year-old woman in pursuit of medical care for her left shoulder pain. Points
      for discussion range from clinical features of Pancoast tumor, importance of pain
      management, good principles of Family Medicine and Palliative care to ethical
      issues of conspiracy of silence, limited treatment plan and palliative versus
      curative radiotherapy treatment without a known biopsy report. This paper
      provides opportunity for analysis of a real complex clinical situation,
      application of medical knowledge to problem solving in clinical practice and
      relevant topics for discussions. (For anonymity sake, the names of patient,
      doctors, general and private hospitals are not mentioned. The aim of this paper
      is solely for continuous medical education without any intention to ridicule any 
      party).
FAU - Khoo, Sb
AU  - Khoo S
AD  - FRACGP, Penang Medical College.
LA  - eng
PT  - Case Reports
DEP - 20101231
PL  - Malaysia
TA  - Malays Fam Physician
JT  - Malaysian family physician : the official journal of the Academy of Family
      Physicians of Malaysia
JID - 101466855
PMC - PMC4170415
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2015/01/22 06:00
PHST- 2015/01/22 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
PST - epublish
SO  - Malays Fam Physician. 2010 Dec 31;5(3):139-44. eCollection 2010.


PMID- 25013586
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140711
LR  - 20211021
IS  - 2008-6482 (Print)
IS  - 2008-6482 (Linking)
VI  - 1
IP  - 4
DP  - 2010
TI  - Pakistan abolishes kidney market and ushers in a new era of ethical
      transplantation.
PG  - 193-7
FAU - Rizvi, S A H
AU  - Rizvi SA
AD  - Sindh Institute of Urology and Transplantation (SIUT), Civil Hospital, Karachi
      74200, Pakistan.
FAU - Anwar Naqvi, S A
AU  - Anwar Naqvi SA
AD  - Sindh Institute of Urology and Transplantation (SIUT), Civil Hospital, Karachi
      74200, Pakistan.
FAU - Zafar, M N
AU  - Zafar MN
AD  - Sindh Institute of Urology and Transplantation (SIUT), Civil Hospital, Karachi
      74200, Pakistan.
FAU - Hussain, Z
AU  - Hussain Z
AD  - Sindh Institute of Urology and Transplantation (SIUT), Civil Hospital, Karachi
      74200, Pakistan.
FAU - Hashmi, A
AU  - Hashmi A
AD  - Sindh Institute of Urology and Transplantation (SIUT), Civil Hospital, Karachi
      74200, Pakistan.
FAU - Akhtar, F
AU  - Akhtar F
AD  - Sindh Institute of Urology and Transplantation (SIUT), Civil Hospital, Karachi
      74200, Pakistan.
FAU - Hussain, M
AU  - Hussain M
AD  - Sindh Institute of Urology and Transplantation (SIUT), Civil Hospital, Karachi
      74200, Pakistan.
FAU - Ahmed, E
AU  - Ahmed E
AD  - Sindh Institute of Urology and Transplantation (SIUT), Civil Hospital, Karachi
      74200, Pakistan.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Int J Organ Transplant Med
JT  - International journal of organ transplantation medicine
JID - 101535773
PMC - PMC4089237
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2014/07/12 06:00
PHST- 2014/07/12 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
PST - ppublish
SO  - Int J Organ Transplant Med. 2010;1(4):193-7.


PMID- 25013566
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140711
LR  - 20211021
IS  - 2008-6482 (Print)
IS  - 2008-6482 (Linking)
VI  - 1
IP  - 2
DP  - 2010
TI  - Living organ donation: an ethical evolution or evolution of ethics?
PG  - 57-62
AB  - The disparity between available and needed organs is rapidly increasing, and the 
      number of patients dying while still on the waiting list is growing
      exponentially. As a partial solution to this disparity, living unrelated
      transplantation is being performed more frequently, and some have proposed
      providing financial incentives to donors. The aim of this discussion is to
      illustrate that with an ever-increasing number of living unrelated
      transplantations, society and the transplant community should adopt a more active
      role in developing specific strategies to scrutinize the process. The current
      paper will also examine the viewpoint that medical ethics is not separable from
      the prevailing needs of society and involves a constant balancing of often
      opposing goods. Issues surrounding living unrelated donor transplantation
      illustrate ethics as a dynamically evolving field, which is often influenced by
      necessity and which evolves with progression of science and society. As part of
      this evolution, it is the collective responsibility of society and the transplant
      community to devise safeguards to guarantee adherence to basic principles of
      ethics and to avoid "situational ethics."
FAU - Ghahramani, N
AU  - Ghahramani N
AD  - Division of Nephrology, Pennsylvania State University College of Medicine, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Iran
TA  - Int J Organ Transplant Med
JT  - International journal of organ transplantation medicine
JID - 101535773
PMC - PMC4089222
OTO - NOTNLM
OT  - Kidney Transplantation
OT  - Medical ethics
OT  - Renal disease
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2014/07/12 06:00
PHST- 2014/07/12 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
PST - ppublish
SO  - Int J Organ Transplant Med. 2010;1(2):57-62.


PMID- 25013559
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140711
LR  - 20211021
IS  - 2008-6482 (Print)
IS  - 2008-6482 (Linking)
VI  - 1
IP  - 1
DP  - 2010
TI  - Cell-based regenerative therapy as an alternative to liver transplantation for
      end-stage liver disease: experience from iran.
PG  - 21-7
AB  - Several types of cells including mature hepatocytes, adult liver progenitor cells
      and human embryonic stem cells, fetal liver progenitor cells, bone marrow derived
      hematopoietic or mesenchymal stem cells, and umbilical cord blood cells-both in
      rodents and humans-have been reported to be capable of self-replication, giving
      rise to daughter hepatocytes, both in vivo and in vitro. They have been shown to 
      be able to repopulate liver in both animal models of liver injury and in patients
      with liver disease and to improve liver function. Human embryonic stem cell
      therapy seems to be a great promise for the treatment of liver cirrhosis, but
      there is no human clinical application due to ethical concerns or difficulties in
      harvesting or safely and efficiently expanding sufficient quantities. In
      contrast, adult bone marrow-derived hematopoietic or mesenchymal stem cells,
      which can be easily and safely harvested, have been used in clinical trials to
      treat several chronic diseases including chronic liver disease. Cell therapy
      offers exciting promise for future treatment of cirrhosis and metabolic liver
      diseases, but significant technical hurdles remain that will only be overcome
      through years of intensive research. There is also serious concern about the
      long-term safety of stem cell therapy and the possibility of tumor development.
      Herein, we present our experience with cell therapy in treatment of chronic liver
      disease in Iran.
FAU - Malekzadeh, R
AU  - Malekzadeh R
AD  - Digestive Disease Research Center, Tehran University of Medical Sciences, Tehran,
      Iran.
FAU - Mohamadnejad, M
AU  - Mohamadnejad M
AD  - Digestive Disease Research Center, Tehran University of Medical Sciences, Tehran,
      Iran.
FAU - Alimoghaddam, K
AU  - Alimoghaddam K
AD  - Hematology, Oncology, BMT Research Center, Tehran University of Medical Sciences,
      Tehran, Iran.
FAU - Bagheri, M
AU  - Bagheri M
AD  - Digestive Disease Research Center, Tehran University of Medical Sciences, Tehran,
      Iran.
FAU - Baharvand, H
AU  - Baharvand H
AD  - Department of Stem Cells and Developmental Biology, and ; Department of
      Regenerative Medicine, Royan Institute for Stem Cell Biology and Technology,
      ACECR, Tehran, Iran.
FAU - Ghavamzadeh, A
AU  - Ghavamzadeh A
AD  - Hematology, Oncology, BMT Research Center, Tehran University of Medical Sciences,
      Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20100201
PL  - Iran
TA  - Int J Organ Transplant Med
JT  - International journal of organ transplantation medicine
JID - 101535773
PMC - PMC4089219
OTO - NOTNLM
OT  - Stem cell
OT  - bone marrow
OT  - cell therapy
OT  - cirrhosis
OT  - liver transplant
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2014/07/12 06:00
PHST- 2009/06/09 00:00 [received]
PHST- 2009/06/24 00:00 [accepted]
PHST- 2014/07/12 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
PST - ppublish
SO  - Int J Organ Transplant Med. 2010;1(1):21-7. Epub 2010 Feb 1.


PMID- 25013558
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140711
LR  - 20211021
IS  - 2008-6482 (Print)
IS  - 2008-6482 (Linking)
VI  - 1
IP  - 1
DP  - 2010
TI  - The concept of death and deceased organ donation.
PG  - 15-20
AB  - An individual who has sustained either irreversible cessation of circulatory and 
      respiratory functions, or irreversible cessation of all functions of the entire
      brain, including the brainstem is dead. A person is not dead unless his brain is 
      dead. The time-honored criteria of stoppage of the heartbeat in circulation are
      indicative of death only when they persist long enough for the brain to die.
      Brain death does not require every brain cell to be nonviable but the criteria
      require an irreversible loss of neurologic function of a patient interminably
      supported by a mechanical respirator. For death to be diagnosed by an
      irreversible cessation of circulation and respiration an absence of circulation
      should be observed for at least two but no more than five minutes.
      Irreversibility is determined by a "permanent" loss of function meaning that the 
      function will not be restored 1) because it will neither return spontaneously,
      nor 2) will it return as a result of medical intervention because physicians have
      decided not to attempt resuscitation.
FAU - Delmonico, F L
AU  - Delmonico FL
AD  - Professor of Surgery, Harvard Medical School, Massachusetts General Hospital
      Transplant Center, Boston, MA, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100201
PL  - Iran
TA  - Int J Organ Transplant Med
JT  - International journal of organ transplantation medicine
JID - 101535773
PMC - PMC4089217
OTO - NOTNLM
OT  - Dead
OT  - brain death
OT  - ethics
OT  - transplant
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2014/07/12 06:00
PHST- 2009/06/20 00:00 [received]
PHST- 2009/07/22 00:00 [accepted]
PHST- 2014/07/12 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
PST - ppublish
SO  - Int J Organ Transplant Med. 2010;1(1):15-20. Epub 2010 Feb 1.


PMID- 25009714
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140710
LR  - 20211021
IS  - 2032-0418 (Print)
IS  - 2032-0418 (Linking)
VI  - 2
IP  - 4
DP  - 2010
TI  - Preconception sex selection for non-medical and intermediate reasons: ethical
      reflections.
PG  - 267-77
AB  - Sex selection for non-medical reasons is forbidden in many countries. Focusing on
      preconception sex selection, the authors first observe that it is unclear what
      should count as a 'medical reason' in this context and argue for the existence of
      'intermediate reasons' that do not fit well within the rigid distinction between 
      'medical'and 'non-medical'. The article further provides a critical review of the
      arguments for the prohibition of sex selection for non-medical reasons and finds 
      that none of these are conclusive. The authors conclude that the ban should be
      reconsidered, but also that existing-- societal concerns about possible harmful
      effects should be taken seriously. Measures to this effect may include limiting
      the practice to couples who already have at least one child of the sex opposite
      to that which they now want to select ('family balancing'). Finally, a difficult 
      set of questions is raised by concerns about the reliability and unproven
      (long-term) safety of the only technology (flow cytometry) proven to work.
FAU - de Wert, G
AU  - de Wert G
AD  - Maastricht University, Faculty of Health, Medicine and Life Sciences, Dept.
      Health, Ethics & Society, Research Institute GROW, P.O. Box 616, 6200 MD
      Maastricht, the Netherlands.
FAU - Dondorp, W
AU  - Dondorp W
AD  - Maastricht University, Faculty of Health, Medicine and Life Sciences, Dept.
      Health, Ethics & Society, Research Institute GROW, P.O. Box 616, 6200 MD
      Maastricht, the Netherlands.
LA  - eng
PT  - Journal Article
PL  - Belgium
TA  - Facts Views Vis Obgyn
JT  - Facts, views & vision in ObGyn
JID - 101578773
PMC - PMC4086011
OTO - NOTNLM
OT  - Preconception sex selection
OT  - ethics
OT  - flow cytometry
OT  - non-medical reasons
OT  - regulation
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2014/07/11 06:00
PHST- 2014/07/11 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
PST - ppublish
SO  - Facts Views Vis Obgyn. 2010;2(4):267-77.


PMID- 24710010
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140408
LR  - 20211021
IS  - 2073-4425 (Print)
IS  - 2073-4425 (Linking)
VI  - 1
IP  - 1
DP  - 2010 May 25
TI  - Next generation DNA sequencing and the future of genomic medicine.
PG  - 38-69
LID - 10.3390/genes1010038 [doi]
AB  - In the years since the first complete human genome sequence was reported, there
      has been a rapid development of technologies to facilitate high-throughput
      sequence analysis of DNA (termed "next-generation" sequencing). These novel
      approaches to DNA sequencing offer the promise of complete genomic analysis at a 
      cost feasible for routine clinical diagnostics. However, the ability to more
      thoroughly interrogate genomic sequence raises a number of important issues with 
      regard to result interpretation, laboratory workflow, data storage, and ethical
      considerations. This review describes the current high-throughput sequencing
      platforms commercially available, and compares the inherent advantages and
      disadvantages of each. The potential applications for clinical diagnostics are
      considered, as well as the need for software and analysis tools to interpret the 
      vast amount of data generated. Finally, we discuss the clinical and ethical
      implications of the wealth of genetic information generated by these methods.
      Despite the challenges, we anticipate that the evolution and refinement of
      high-throughput DNA sequencing technologies will catalyze a new era of
      personalized medicine based on individualized genomic analysis.
FAU - Anderson, Matthew W
AU  - Anderson MW
AD  - Department of Pathology, Stanford University Medical Center, 300 Pasteur Drive,
      Room L235, Stanford, CA 94305-5627, USA. mwanders@stanford.edu.
FAU - Schrijver, Iris
AU  - Schrijver I
AD  - Department of Pathology, Stanford University Medical Center, 300 Pasteur Drive,
      Room L235, Stanford, CA 94305-5627, USA. ischrijver@stanfordmed.org.
LA  - eng
PT  - Journal Article
DEP - 20100525
PL  - Switzerland
TA  - Genes (Basel)
JT  - Genes
JID - 101551097
PMC - PMC3960862
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2014/04/09 06:00
PHST- 2010/04/15 00:00 [received]
PHST- 2010/05/20 00:00 [revised]
PHST- 2010/05/21 00:00 [accepted]
PHST- 2014/04/09 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - genes1010038 [pii]
AID - 10.3390/genes1010038 [doi]
PST - epublish
SO  - Genes (Basel). 2010 May 25;1(1):38-69. doi: 10.3390/genes1010038.


PMID- 24693054
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140620
LR  - 20211021
IS  - 0973-7154 (Print)
IS  - 0973-7154 (Linking)
VI  - 6
IP  - 1
DP  - 2010
TI  - Induced pluripotent stem (iPS) cells offer a powerful new tool for the life
      sciences.
PG  - 2-9
AB  - Stem cell biology started with the analysis of somatic stem cells that function
      to maintain the adult body. We now know that the body is maintained by
      regeneration of a wide range of cell types, such as skin cells, blood cells and
      gastrointestinal mucous cells, from somatic stem cells. This regenerative
      activity is essential for survival. Regenerative medicine was initiated to
      identify therapies that support and/or accelerate this natural regenerative
      ability. For example, bone marrow transplantation is a therapy for reconstituting
      hematopoiesis from the hematopoietic stem cells present in the donor bone marrow.
      The successful development of a protocol for obtaining human embryonic stem (ES) 
      cells prompted medical scientists to utilize human ES cells for regenerative
      medicine. However, use of these cells raises ethical issues as they are derived
      from human embryos. An alternative approach using ES-like pluripotent stem cells 
      has the considerable advantage that it does not necessitate use of human embryos.
      Pluripotent stem cells can be induced from terminally differentiated somatic
      cells by the introduction of only four defined factors. The products of this
      method are termed "induced pluripotent stem (iPS)" cells. iPS cells have
      considerable promise as a substitute for ES cells not only for regenerative
      medicine but also in many other fields. For example, liver and heart cells
      derived from iPS cells can be used in pharmaceutical research. In addition, iPS
      cell technology opens new avenues of disease research, for example, by
      construction of so-called "disease-specific iPS cells" from a patient's somatic
      cells.
FAU - Nakamura, Y
AU  - Nakamura Y
AD  - Cell Engineering Division, RIKEN BioResource Center, Tsukuba, Ibaraki, Japan.
LA  - eng
PT  - Journal Article
DEP - 20100405
PL  - India
TA  - J Stem Cells Regen Med
JT  - Journal of stem cells & regenerative medicine
JID - 101552911
PMC - PMC3908254
OTO - NOTNLM
OT  - Disease specific iPS cells
OT  - ES cells
OT  - Regenerative medicine
OT  - iPS cells
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2014/04/03 06:00
PHST- 2014/04/03 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
PST - epublish
SO  - J Stem Cells Regen Med. 2010 Apr 5;6(1):2-9. eCollection 2010.


PMID- 24493979
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20211021
IS  - 1512-7680 (Print)
IS  - 1512-7680 (Linking)
VI  - 22
IP  - 1
DP  - 2010
TI  - Medicine, media communication and ethical aspects.
PG  - 6-13
LID - 10.5455/msm.2010.22.6-13 [doi]
AB  - On World Press Freedom Day (3rd of May 2009) details of the Frida Haus ranking
      list of press freedom in countries around the world were officially disclosed.
      Bosnia and Herzegovina is ranked at 98 place, and in the region better ranked is 
      only Montenegro, which is located between 78 and 80 place along with Botswana and
      Eastern Timor. Top rated is Iceland with 9 points and on the last place is North 
      Korea, with 98 points. Almost every profession has its deontology/ethical
      principles. However, medicine and the media are specifically targeted by public
      controversy with regard to the consequences of their responsibilities for the
      individual and the overall population. Until twenty years ago, the media were the
      main social system or a reflection of the social system and dominated the field
      of public communication, which implicitly reflected in the organization,
      operation and effects of companies, corporations, etc. as the overall social
      system, increasing the gross national product and its various categories enabled 
      boom. Medicine and health represent to a wide range of people, perhaps, the most 
      interesting source of information, and probably there isn't a person that once
      was not interested in quality professional and verified information regarding
      some of their medical condition or overall health status. It is estimated that
      today there are more than a million Web sites on health and diseases, which means
      that the availability of health information for users is better today than ever
      before. However, it is important to patients and users of web sites with health
      information to learn how to properly use them, and learn to assess whether the
      information published on this site are of reliable quality, which depends on the 
      authors who put the information on the web site, their topicality, simplicity in 
      use and especially the diversity of the medical content of these web pages. It is
      the Internet that allows the revolution in relation patient-health care- health
      services provider. First look is at the symptoms and other health information on 
      the Internet before patients actually go to the doctor. In response to this there
      is change in the relation patient- doctor, there are attempts to allow the
      patient to make a test, for example, cholesterol in the blood prior to scheduling
      the examination by the doctor. The vision of the future is Web-based and secure
      health record (Medical Record) that can be maintained in some kind of health plan
      or supervised by a physician. Such a site can be used when the patient is
      traveling or when he or she goes to the pharmacy or doctor of any specialty.
      Access to appropriate information may strengthen patients to express their
      demands and medical professionalism in order to improve clinical decision making.
      Information on support of patients and their involvement in prevention,
      alternative treatments and their care should be a central part of quality
      improvement strategies. Improving the quality of information and helping people
      use the most of what is offered have to be realized by implementing the
      strategies. Governments should invest in public education programs to encourage
      people to critically evaluate health information. For their share, they will have
      to be aware of the scope and quality of information sources that can be used by
      patients, so that they can get advice from them in an appropriate manner.
FAU - Masic, Izet
AU  - Masic I
AD  - Department of Family Medicine, Medical Faculty of Sarajevo University , Bosnia
      and Herzegovina.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Bosnia and Herzegovina
TA  - Mater Sociomed
JT  - Materia socio-medica
JID - 101281595
PMC - PMC3813544
OTO - NOTNLM
OT  - ethical aspects
OT  - media
OT  - medicine
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2014/02/05 06:00
PHST- 2009/11/11 00:00 [received]
PHST- 2009/12/25 00:00 [accepted]
PHST- 2014/02/05 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - 10.5455/msm.2010.22.6-13 [doi]
PST - ppublish
SO  - Mater Sociomed. 2010;22(1):6-13. doi: 10.5455/msm.2010.22.6-13.


PMID- 24475543
OWN - NLM
STAT- MEDLINE
DCOM- 20140212
LR  - 20140130
IS  - 1064-590X (Print)
IS  - 1064-590X (Linking)
VI  - 65
IP  - 2
DP  - 2010
TI  - Saving U.S. dietary advice from conflicts of interest.
PG  - 285-316, ii
AB  - A large and growing majority of people are dying from chronic diseases. To a
      large extent, however, whether this happens is up to us and the choices we make, 
      since diet and lifestyle can prevent, slow, and even reverse these diseases. The 
      government tries to inform the public about these healthy choices in the Dietary 
      Guidelines for Americans. Unfortunately, the integrity of that advice has
      potentially been compromised by conflicts of interest among the people and
      organizations responsible for the Guidelines. As a result, as several studies
      show, the Guidelines are far less effective than other diets--especially the
      Mediterranean diet--at reducing the risk for chronic diseases. Improving the
      Guidelines would require eliminating these conflicts of interest, which would
      involve two statutory changes. First, Congress should give the authority to
      create dietary advice solely to an appropriate health agency, not the U.S.
      Department of Agriculture, which cannot give accurate and impartial dietary
      advice while also promoting agricultural interests. Second, Congress should find 
      a way generally to prohibit individuals with ties to the food and drug industries
      from serving on the Dietary Guidelines Advisory Committee, as current ethical
      standards ignore the influence of past ties, and they are far too specific to
      address different forms of conflicts.
FAU - Herman, Jeff
AU  - Herman J
AD  - Saint Louis University School of Law, St. Louis, Missouri, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Food Drug Law J
JT  - Food and drug law journal
JID - 9215384
MH  - Agriculture
MH  - Chronic Disease/prevention & control
MH  - Conflict of Interest/*legislation & jurisprudence
MH  - Diet
MH  - Health Promotion
MH  - Humans
MH  - Life Style
MH  - Nutrition Policy/*legislation & jurisprudence
MH  - United States
MH  - United States Department of Agriculture/ethics/legislation & jurisprudence
MH  - United States Dept. of Health and Human Services/ethics/legislation &
      jurisprudence
EDAT- 2010/01/01 00:00
MHDA- 2014/02/13 06:00
CRDT- 2014/01/31 06:00
PHST- 2014/01/31 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2014/02/13 06:00 [medline]
PST - ppublish
SO  - Food Drug Law J. 2010;65(2):285-316, ii.


PMID- 24198560
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131107
LR  - 20211021
IS  - 1179-1543 (Print)
IS  - 1179-1543 (Linking)
VI  - 1
DP  - 2010
TI  - Placebo effect of an inert gel on experimentally induced leg muscle pain.
PG  - 215-21
LID - 10.2147/OAJSM.S13564 [doi]
AB  - PURPOSE: This study examined the therapeutic effects of an inert placebo gel on
      experimentally induced muscle pain in a sports therapy setting. It aimed to
      investigate the degree to which conditioned analgesia, coupled with an
      expectation of intervention, was a factor in subsequent analgesia. METHODS:
      Participants were sixteen male and eight female sports therapy students at a UK
      University. With institutional ethics board approval and following informed
      consent procedures, each was exposed to pain stimulus in the lower leg in five
      conditions, ie, conditioning, prebaseline, experimental (two placebo gel
      applications), and postbaseline. In conditioning trials, participants identified 
      a level of pain stimulus equivalent to a perceived pain rating of 6/10. An inert 
      placebo gel was then applied to the site with the explicit instruction that it
      was an analgesic. Participants were re-exposed to the pain stimulus, the level of
      which, without their knowledge, had been decreased, creating the impression of an
      analgesic effect resulting from the gel. In experimental conditions, the placebo 
      gel was applied and the level of pain stimulus required to elicit a pain rating
      of 6/10 recorded. RESULTS: Following application of the placebo gel, the level of
      pain stimulus required to elicit a pain rating of 6/10 increased by 8.2%.
      Application of the placebo gel significantly decreased participant's perceptions 
      of muscle pain (P = 0.001). CONCLUSION: Subjects' experience and expectation of
      pain reduction may be major factors in the therapeutic process. These factors
      should be considered in the sports therapeutic environment.
FAU - Hopker, James G
AU  - Hopker JG
AD  - Centre for Sports Studies, University of Kent, Chatham, Kent, UK.
FAU - Foad, Abigail J
AU  - Foad AJ
FAU - Beedie, Christopher J
AU  - Beedie CJ
FAU - Coleman, Damian A
AU  - Coleman DA
FAU - Leach, Geoffrey
AU  - Leach G
LA  - eng
PT  - Journal Article
DEP - 20101119
PL  - New Zealand
TA  - Open Access J Sports Med
JT  - Open access journal of sports medicine
JID - 101566036
PMC - PMC3781872
OTO - NOTNLM
OT  - conditioning
OT  - expectation
OT  - perception
OT  - positive belief
OT  - sports therapy
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2013/11/08 06:00
PHST- 2013/11/08 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - 10.2147/OAJSM.S13564 [doi]
AID - oajsm-1-215 [pii]
PST - epublish
SO  - Open Access J Sports Med. 2010 Nov 19;1:215-21. doi: 10.2147/OAJSM.S13564.
      eCollection 2010.


PMID- 24198524
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20211021
IS  - 1178-6957 (Print)
IS  - 1178-6957 (Linking)
VI  - 3
DP  - 2010 Dec 6
TI  - Potential sources of stem cells as a regenerative therapy for Parkinson's
      disease.
PG  - 183-91
LID - 10.2147/SCCAA.S14626 [doi]
AB  - Stem cells are believed to hold enormous promise as potential replacement therapy
      in the treatment of neurodegenerative diseases such as Parkinson's disease (PD). 
      Stem cells were investigated to be the alternative therapeutic source capable of 
      differentiating into dopamine (DA) neurons. Multiple important signaling factors 
      were recorded for the induction of DA neuronal traits from mouse embryonic stem
      cells (ESCs) such as fibroblast growth factor 8, sonic hedgehog, and Wnt 1.
      Recent protocols were described for the differentiation of human ESCs into DA
      neurons, achieving high efficiency of DA neuronal derivation. Despite that, the
      use of human ESCs is still ethically controversial. The transcription factors
      necessary for DA neuron development from adult neural stem cells (NSCs), such as 
      Pitx3, Nurr1, En-1, En-2, Lmx1a, Lmx1b, Msx1, and Ngn2, were investigated. In
      addition to replacement of lost DA neurons, adult NSCs were recorded to provide
      neuroprotective and neurogenic factors for the mesencephalon. In addition,
      induced pluripotent stem cells and bone marrow-derived mesenchymal stem cells
      represent reliable stem cell sources of DA neurons. Future studies are
      recommended to provide further insight into the regenerative capacity of stem
      cells needed for the treatment of PD.
FAU - El-Sadik, Abir Oueida
AU  - El-Sadik AO
AD  - Department of Anatomy and Embryology, Scientific Research Unit, Female Health
      Science College, King Saud University, Riyadh, Kingdom of Saudi Arabia.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20101206
PL  - New Zealand
TA  - Stem Cells Cloning
JT  - Stem cells and cloning : advances and applications
JID - 101535817
PMC - PMC3781753
OTO - NOTNLM
OT  - Parkinson's disease
OT  - dopamine
OT  - embryonic stem cells
OT  - induced pluripotent stem cells
OT  - mesenchymal stem cells
OT  - neural stem cells
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2013/11/08 06:00
PHST- 2013/11/08 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - 10.2147/SCCAA.S14626 [doi]
AID - sccaa-3-183 [pii]
PST - epublish
SO  - Stem Cells Cloning. 2010 Dec 6;3:183-91. doi: 10.2147/SCCAA.S14626.


PMID- 23908742
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130805
LR  - 20211021
IS  - 2008-0387 (Print)
IS  - 2008-0387 (Linking)
VI  - 3
DP  - 2010
TI  - The necessity of observing ethical liability in bioethics: Instruction of the
      principles of bioethics should be launched from school.
PG  - 7
FAU - Pourabbasi, Ata
AU  - Pourabbasi A
AD  - MD, Research fellow, Endocrinology & Metabolism Research center, Tehran
      University of Medical Sciences, Iran; Ehsan Educational & Cultural Institute
      Endocrinology and Metabolism Research Center, Shariati Hospital, Kargar Street.
FAU - Bina, Meysam Tavakkoli
AU  - Bina MT
FAU - Sanjari, Mahnaz
AU  - Sanjari M
LA  - eng
PT  - Journal Article
DEP - 20101228
PL  - Iran
TA  - J Med Ethics Hist Med
JT  - Journal of medical ethics and history of medicine
JID - 101606442
PMC - PMC3713950
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2013/08/03 06:00
PHST- 2010/10/02 00:00 [received]
PHST- 2010/12/26 00:00 [accepted]
PHST- 2013/08/03 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
PST - epublish
SO  - J Med Ethics Hist Med. 2010 Dec 28;3:7. Print 2010.


PMID- 23908740
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130805
LR  - 20220310
IS  - 2008-0387 (Print)
IS  - 2008-0387 (Linking)
VI  - 3
DP  - 2010
TI  - Evaluation of moral competency using standardized patient: presenting an
      experience.
PG  - 5
AB  - In this study we discuss our experience of including an ethics objective
      structured clinical examination (OSCE) station in endocrinology board exam. One
      OSCE station on truth telling was developed and a standardized patient was
      trained for role playing in this station. Based on a pilot study, the evaluation 
      checklist got modified. Then the finalized station added into the OSCE phase of
      endocrinology board exam. Based on this experience, adding ethics station in
      board exams is practical and reasonable. Since OSCE method could evaluate
      students' ethical decision making and communication skill it could be used in
      combination with other kinds of evaluation in assessing ethics competency of
      graduates. Using this method could push the ethics learning approach toward more 
      practical and skill based ones.
FAU - Asghari, Fariba
AU  - Asghari F
AD  - Medical Ethics and History of Medicine Research Center, Tehran University of
      Medical Sciences, Tehran, Iran.
FAU - Larijani, Bagher
AU  - Larijani B
LA  - eng
PT  - Journal Article
DEP - 20101030
PL  - Iran
TA  - J Med Ethics Hist Med
JT  - Journal of medical ethics and history of medicine
JID - 101606442
PMC - PMC3714008
OTO - NOTNLM
OT  - Evaluation
OT  - Medical ethics
OT  - OSCE
OT  - Standardized patient
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2013/08/03 06:00
PHST- 2010/01/03 00:00 [received]
PHST- 2010/09/08 00:00 [accepted]
PHST- 2013/08/03 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
PST - epublish
SO  - J Med Ethics Hist Med. 2010 Oct 30;3:5. Print 2010.


PMID- 23908739
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130805
LR  - 20211021
IS  - 2008-0387 (Print)
IS  - 2008-0387 (Linking)
VI  - 3
DP  - 2010
TI  - Caring relationship: the core component of patients' rights practice as
      experienced by patients and their companions.
PG  - 4
AB  - The aim of this article is to describe how Iranian patients and their companions 
      explain their lived experiences with caring relationships in a central teaching
      hospital in Tehran, Iran. Despite a large number of theoretical articles on this 
      topic, the meaning of caring is still ambiguous, particularly in specific
      cultures. In Iran, there is not enough qualitative evidence on this topic to
      indicate what patients actually mean when they refer to caring relationship. This
      article explores how Iranian patients and their companions perceive and describe 
      caring relationships as an element of patients' rights practice. This is part of 
      a phenomenological research on patients' rights practice in Iran conducted during
      2003-2006. Semi-structured interviews were conducted with 16 patients/companions,
      and van Mannen's approach was used for thematic analysis. The ethics committee of
      Tehran University of Medical Sciences approved the study. Patient-centered care, 
      compassion, effective communication, support/advocacy, informed participation and
      meeting patients' basic needs were found to be the key elements in defining
      caring relationships. These themes were all described as elements of patients'
      rights practice issues. The results indicated that it is necessary for care
      givers/nurses to understand the person who will receive care in order to provide 
      zealous and authentic care, because feeling "to be cared for" is even more
      important than providing the "care" itself.
FAU - Joolaee, S
AU  - Joolaee S
AD  - Assistant Professor, Nursing Care Research Center and School of Nursing and
      Midwifery, Iran University of Medical Sciences, Tehran, Iran.
FAU - Joolaei, A
AU  - Joolaei A
FAU - Tschudin, V
AU  - Tschudin V
FAU - Bahrani, N
AU  - Bahrani N
FAU - Nikbakht Nasrabadi, A
AU  - Nikbakht Nasrabadi A
LA  - eng
PT  - Journal Article
DEP - 20101009
PL  - Iran
TA  - J Med Ethics Hist Med
JT  - Journal of medical ethics and history of medicine
JID - 101606442
PMC - PMC3714119
OTO - NOTNLM
OT  - Caring relationship
OT  - Lived experiences
OT  - Patients' rights
OT  - Patient's companion
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2013/08/03 06:00
PHST- 2010/09/07 00:00 [received]
PHST- 2010/09/28 00:00 [accepted]
PHST- 2013/08/03 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
PST - epublish
SO  - J Med Ethics Hist Med. 2010 Oct 9;3:4. Print 2010.


PMID- 23908738
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130805
LR  - 20220409
IS  - 2008-0387 (Print)
IS  - 2008-0387 (Linking)
VI  - 3
DP  - 2010
TI  - Professional Ethical Competence in nursing: the role of nursing instructors.
PG  - 3
AB  - Teaching ethics to nurses leads to their involvement in providing high quality
      care, enable them to duly encounter ethical issues. One of the key elements of
      educational systems is nursing instructors. Even though lots of studies show the 
      role of instructors in students' learning, their role in promotion of
      professional ethics has been attended to less. The objective of this study is
      surveying the experience of nursing students with respect to the role of
      instructors in promotion of professional ethics. This qualitative study enrolled 
      15 undergraduate nursing students from three nursing schools in Teheran whom
      depth interview was performed. The interview was semi-structured with open ended 
      questions. The analysis was accomplished by use of qualitative content-analysis
      method. Data analysis demonstrated 2 main themes and 7 subcategories in regard to
      the role of instructors in promotion of professional ethics in nursing students
      including: 1) the effective professional role model 2) facilitating creative
      learning. The effective professional role model encompasses individual
      characteristics and beliefs, clinical skills and professional commitment of role 
      model. Creative learning facilitates by encouraging critical thinking and
      decision-making, Providing supportive learning conditions, providing proper space
      for sharing knowledge followed by evaluation and creative feedback. The findings 
      of this study provides a background for strengthening the role of instructors in 
      promotion of professional ethics with more emphasis on research which increase
      capability of instructors at nursing education centers.
FAU - Borhani, Fariba
AU  - Borhani F
AD  - PhD Nursing student, Tarbiat Modares University, Tehran, Iran;
FAU - Alhani, Fatemeh
AU  - Alhani F
FAU - Mohammadi, Easa
AU  - Mohammadi E
FAU - Abbaszadeh, Abbas
AU  - Abbaszadeh A
LA  - eng
PT  - Journal Article
DEP - 20100708
PL  - Iran
TA  - J Med Ethics Hist Med
JT  - Journal of medical ethics and history of medicine
JID - 101606442
PMC - PMC3714123
OTO - NOTNLM
OT  - Ethics
OT  - Nursing
OT  - Nursing student
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2013/08/03 06:00
PHST- 2010/02/26 00:00 [received]
PHST- 2010/06/26 00:00 [accepted]
PHST- 2013/08/03 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
PST - epublish
SO  - J Med Ethics Hist Med. 2010 Jul 8;3:3. Print 2010.


PMID- 23908737
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130805
LR  - 20211021
IS  - 2008-0387 (Print)
IS  - 2008-0387 (Linking)
VI  - 3
DP  - 2010
TI  - Donated materials in assisted reproductive technologies: an ethico-legal analysis
      of art legislations worldwide.
PG  - 2
AB  - This paper provides an appraisal of countries that have legislations pertaining
      to assisted reproductive technologies (ART). In doing so, the paper highlights
      the emphasis on the protection of reproductive freedom of the couples seeking ART
      treatment. This belief is grounded primarily on the basic notion of liberalism
      that attaches primary importance to respect for individual freedom, which is the 
      foundation of the notion of reproductive rights as understood by western
      standards today. The main aim of the appraisal is to see how these legislations
      address the drastic changes in familial relationships when ART involves the use
      of donated materials.
FAU - Zawawi, Majdah
AU  - Zawawi M
AD  - Department of Islamic Law, Ahmad Ibrahim Kulliyyah of Laws, International Islamic
      University Malaysia, Jalan Gombak, 53100 Kuala Lumpur, Malaysia, Tel: 603-6196
      4351, , E-Mail: z.majdah@iiu.edu.my.
LA  - eng
PT  - Journal Article
DEP - 20100621
PL  - Iran
TA  - J Med Ethics Hist Med
JT  - Journal of medical ethics and history of medicine
JID - 101606442
PMC - PMC3714004
OTO - NOTNLM
OT  - Assisted
OT  - Embryo
OT  - Ethics
OT  - Plant gametes
OT  - Reproductive techniques
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2013/08/03 06:00
PHST- 2010/02/01 00:00 [received]
PHST- 2010/06/15 00:00 [accepted]
PHST- 2013/08/03 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
PST - epublish
SO  - J Med Ethics Hist Med. 2010 Jun 21;3:2. Print 2010.


PMID- 23908736
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130805
LR  - 20211021
IS  - 2008-0387 (Print)
IS  - 2008-0387 (Linking)
VI  - 3
DP  - 2010
TI  - AIDS and drug rationing.
PG  - 1
AB  - Financial shortage in resource-limited and poor countries restricts treatment in 
      HIV-infected patients especially in poor countries. Higher HIV prevalence in
      poorer countries makes drug rationing a real concern. Different countries solve
      the problem with different methods regarding WHO guidelines, but fairness and
      equity should be a major consideration in drug rationing. This paper is aimed at 
      reviewing different strategic approaches to drug rationing in AIDS treatment and 
      then discusses pharmacists' role. In conclusion, there is no fair and equitable
      strategy, and in each society, cultural, ethical and socioeconomic issues along
      with considering a critical role for pharmacists must be taken into account.
FAU - Sharif, Pooneh Salari
AU  - Sharif PS
AD  - Assistant Professor, Medical Ethics and History of Medicine Research Center,
      Tehran University of Medical Sciences, Tehran Iran.
FAU - Noroozi, Mahshad
AU  - Noroozi M
LA  - eng
PT  - Journal Article
DEP - 20100316
PL  - Iran
TA  - J Med Ethics Hist Med
JT  - Journal of medical ethics and history of medicine
JID - 101606442
PMC - PMC3713939
OTO - NOTNLM
OT  - AIDS
OT  - ethics
OT  - pharmacist
OT  - rationing
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2013/08/03 06:00
PHST- 2010/01/19 00:00 [received]
PHST- 2010/03/07 00:00 [accepted]
PHST- 2013/08/03 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
PST - epublish
SO  - J Med Ethics Hist Med. 2010 Mar 16;3:1. Print 2010.


PMID- 23776359
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130619
LR  - 20211021
IS  - 1178-704X (Print)
IS  - 1178-704X (Linking)
VI  - 3
DP  - 2010
TI  - Genetic screening for homozygous and heterozygous familial hypercholesterolemia.
PG  - 147-57
LID - 10.2147/TACG.S13490 [doi]
AB  - Familial hypercholesterolemia (FH) is a common inherited disorder that results in
      premature atherosclerosis. Diagnosis of FH is suspected on the basis of clinical 
      criteria, but confirmation requires genetic testing. In the era of statins, early
      diagnosis and initiation of treatment can modify disease progression and
      outcomes. Therefore, cascade screening with a combination of lipid concentration 
      measurements and DNA testing should be used to identify relatives of index cases 
      with a clinical diagnosis of FH. Autosomal dominant FH is related to mutations in
      the low-density lipoprotein receptor (LDLR), apolipoprotein B-100 (APOB), or
      proprotein convertase subtilisin/kexin type 9 (PCSK9) genes. Genetic screening of
      the LDLR gene is challenging to achieve at a feasible cost, especially in people 
      who do not have a founder effect. Nucleotide sequencing of all exons and flanking
      splicing regions in combination with multiplex ligation probe amplification to
      detect large insertions or deletions is considered the gold-standard approach to 
      screen for LDLR mutations. Alternatively, the cDNA can be sequenced; however,
      this procedure is not suitable for use in large populations, because of the need 
      of RNA extraction. Multiplex analysis can be appropriate for population with
      founder effects or a low number of different mutations. Finally, there are many
      techniques for a mutation scanning approach, which have some benefits over
      sequencing, and also with the potential for detecting known and novel mutations. 
      Familial defective Apo B is amenable to genetic diagnosis by screening for a few 
      mutations. Recently, gain-of-function mutations in PCSK9 gene have been
      demonstrated to cause FH phenotype. Strategies for population screening,
      cost-effectiveness of genetic screening, ethical aspects, and insurance policies 
      are discussed and need implementation worldwide.
FAU - Izar, Maria C
AU  - Izar MC
AD  - Cardiology Division, Department of Medicine, Federal University of Sao Paulo,
      UNIFESP, Sao Paulo, SP, Brazil.
FAU - Machado, Valeria A
AU  - Machado VA
FAU - Fonseca, Francisco A
AU  - Fonseca FA
LA  - eng
PT  - Journal Article
DEP - 20101208
PL  - New Zealand
TA  - Appl Clin Genet
JT  - The application of clinical genetics
JID - 101579789
PMC - PMC3681171
OTO - NOTNLM
OT  - cholesterol
OT  - familial defective Apo B
OT  - familial hypercholesterolemia
OT  - genetic screening
OT  - mutations
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2013/06/19 06:00
PHST- 2013/06/19 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - 10.2147/TACG.S13490 [doi]
AID - tacg-3-147 [pii]
PST - epublish
SO  - Appl Clin Genet. 2010 Dec 8;3:147-57. doi: 10.2147/TACG.S13490. Print 2010.


PMID- 23620829
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 2151-805X (Print)
IS  - 2151-805X (Linking)
VI  - 1
IP  - 4
DP  - 2010
TI  - Protecting Privacy and Confidentiality in Environmental Health Research.
PG  - 285-291
AB  - Environmental health researchers often need to make difficult decisions on how to
      protect privacy and confidentiality when they conduct research in the home or
      workplace. These dilemmas are different from those normally encountered in
      clinical research. Although protecting privacy and confidentiality is one of the 
      most important principles of research involving human subjects, it can be
      overridden to prevent imminent harm to individuals or if required by law.
      Investigators should carefully consider the facts and circumstances and use good 
      judgment when deciding whether to breach privacy or confidentiality.
FAU - Resnik, David B
AU  - Resnik DB
AD  - National Institute of Environmental Health Sciences, National Institutes of
      Health, Box 12233, Mail Drop CU03, Research Triangle Park, NC 27709.
LA  - eng
GR  - ZIA ES102646-03/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Ethics Biol Eng Med
JT  - Ethics in biology, engineering & medicine
JID - 101527948
PMC - PMC3633517
MID - NIHMS328913
OTO - NOTNLM
OT  - confidentiality
OT  - environmental health research
OT  - ethics
OT  - home
OT  - informed consent
OT  - privacy
OT  - workplace
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2013/04/27 06:00
PHST- 2013/04/27 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - 10.1615/EthicsBiologyEngMed.v1.i4 [doi]
PST - ppublish
SO  - Ethics Biol Eng Med. 2010;1(4):285-291. doi: 10.1615/EthicsBiologyEngMed.v1.i4.


PMID- 23616839
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130426
LR  - 20211021
IS  - 1869-0327 (Print)
IS  - 1869-0327 (Linking)
VI  - 1
IP  - 3
DP  - 2010
TI  - Confronting and resolving an ethical dilemma associated with a practice based
      evaluation using observational methodology of health information technology.
PG  - 244-55
LID - 10.4338/ACI-2010-02-CR-0014 [doi]
AB  - SUMMARY: As the adoption of health information technology (HIT) has escalated,
      efforts to evaluate its uptake have increased. The evaluation of HIT often
      requires direct observation of health care practitioners interacting with the
      system. When in the field, the evaluator who is not a trained health care
      provider may observe suboptimal use of the technology. If evaluators have plans
      to share the results of the evaluation at the conclusion of the study, they face 
      a decision point about whether to disclose interim results and the implications
      of doing so. To provide HIT evaluators with guidance about what issues to weigh
      when observing the implementation of HIT, this paper presents a study of an
      actual case and discusses the following considerations: (1) whether the
      evaluation of HIT is considered to be human subject research; (2) if the
      evaluation is human subject research, whether the Institutional Review Board will
      consider it exempt from review or subjected to expedited or full review; and (3) 
      how interim disclosure to the clinic management impacts the research study. The
      recommendations to evaluators include use of a protocol for interim disclosures
      to patients, clinicians, and/or clinical management for both quality assurance
      initiatives and human subjects research.
FAU - Sockolow, P S
AU  - Sockolow PS
AD  - College of Nursing and Health Professions, Drexel University , Philadelphia,
      Pennsylvania.
FAU - Taylor, H A
AU  - Taylor HA
LA  - eng
GR  - T15 LM007452/LM/NLM NIH HHS/United States
PT  - Journal Article
DEP - 20100728
PL  - Germany
TA  - Appl Clin Inform
JT  - Applied clinical informatics
JID - 101537732
PMC - PMC3631900
OTO - NOTNLM
OT  - Testing and evaluation
OT  - clinical information systems
OT  - ethics
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2013/04/26 06:00
PHST- 2010/02/28 00:00 [received]
PHST- 2010/07/02 00:00 [accepted]
PHST- 2013/04/26 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - 10.4338/ACI-2010-02-CR-0014 [doi]
PST - epublish
SO  - Appl Clin Inform. 2010 Jul 28;1(3):244-55. doi: 10.4338/ACI-2010-02-CR-0014.
      Print 2010.


PMID- 23526859
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 0047-651X (Print)
IS  - 0047-651X (Linking)
VI  - 37
IP  - 2
DP  - 2010
TI  - Mapping Postgraduate Research at the University of Zambia: a review of
      dissertations for the Master of Medicine Programme.
PG  - 52-57
AB  - BACKGROUND: The publication of a dissertation is an integral part of the
      four-year postgraduate degree of Master of Medicine (in clinical disciplines)
      within the School of Medicine at the University of Zambia. The governing research
      policy states that the subject matter of the dissertation is expected to cover a 
      topic relevant to health care in the Zambian context, that it be conducted in a
      way that is consistent with international ethical guidelines for biomedical
      research involving human subjects, and that research outcomes should be maximally
      utilized. The aim of the study is to explore the characteristics of the Masters
      of Medicine research at the University of Zambia. METHODOLOGY: This descriptive
      study explores the subject matter and research methodology by type of clinical
      specialty of all dissertations from 1986 to 2009. RESULTS: The 132 dissertations 
      included 36 (27.3%) in Surgery, 35 (26.5%) in Paediatrics, 32 (24.2%) in Internal
      Medicine, 24 (18.2%) in Obstetrics and Gynaecology, and 5 (3.8%) in Orthopaedic
      Surgery. Only 7 (5.3%) were interventional/experimental studies (4 of which were 
      randomized controlled trials). Cross-sectional studies were the predominant type 
      of the 125 observational studies (n=112, 84.8%). Thirty-three dissertations
      (25.0%) predominantly addressed HIV (16 Internal Medicine, 10 Paediatrics, 6
      Surgery and 1 Obstetrics and Gynaecology); and 18 (13.6%) predominantly addressed
      infections, excluding TB (11 in Paediatrics). Other subjects included malignancy 
      (n=6), TB (n=5), and diabetes mellitus (n=4). Over half of the dissertations (76,
      57.6%) addressed the determinants of the cause, risk and development of diseases;
      and a third dealt with management and evaluation of diseases (26 and 18,
      respectively). CONCLUSIONS: Few dissertations were based on experimental designs 
      and most addressed determinants of the cause of diseases through cross-sectional 
      studies. HIV and infections predominate as diseases reflecting the prevailing
      disease patterns in Lusaka in particular, and Zambia in general.
FAU - Ahmed, Y
AU  - Ahmed Y
AD  - Department of Obstetrics and Gynaecology, School of Medicine, University of
      Zambia, Lusaka, Zambia.
FAU - Kanyengo, Cw
AU  - Kanyengo C
FAU - Akakandelwa, Akakandelwa
AU  - Akakandelwa A
LA  - eng
GR  - D43 TW001035/TW/FIC NIH HHS/United States
PT  - Journal Article
PL  - Zambia
TA  - Med J Zambia
JT  - Medical journal of Zambia
JID - 0251103
PMC - PMC3604980
MID - NIHMS414032
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2013/03/26 06:00
PHST- 2013/03/26 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
PST - ppublish
SO  - Med J Zambia. 2010;37(2):52-57.


PMID- 23441254
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130227
LR  - 20211021
IS  - 2037-0504 (Print)
IS  - 2037-0504 (Linking)
VI  - 2
IP  - 2
DP  - 2010
TI  - Ethics and methodology, not bureaucracy.
PG  - 77-9
FAU - Landoni, G
AU  - Landoni G
AD  - Department of Anesthesia and Intensive Care, Universita Vita-Salute San Raffaele,
      Milan, Italy.
FAU - Zangrillo, A
AU  - Zangrillo A
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - HSR Proc Intensive Care Cardiovasc Anesth
JT  - HSR proceedings in intensive care & cardiovascular anesthesia
JID - 101522989
PMC - PMC3484618
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2013/02/27 06:00
PHST- 2013/02/27 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
PST - ppublish
SO  - HSR Proc Intensive Care Cardiovasc Anesth. 2010;2(2):77-9.


PMID- 23431638
OWN - NLM
STAT- MEDLINE
DCOM- 20130401
LR  - 20201209
IS  - 0375-0760 (Print)
IS  - 0375-0760 (Linking)
VI  - 62
IP  - 1
DP  - 2010 Jan-Apr
TI  - [Protective efficacy of Heberbiovac HB at different dosage in physically and
      mentally-handicapped children].
PG  - 58-64
AB  - INTRODUCTION: the protective efficacy follow-up studies in high risk groups for
      hepatitis B virus infection, which were inoculated with recombinant hepatitis B
      vaccines, are limited and the duration of protection is yet to be determined in
      those vaccinated people. OBJECTIVES: to determine the protective efficacy of
      Heberbiovac HB vaccine at different dosage in physically and mentally-handicapped
      children after 14 years of the primary vaccination schedule. METHODS: in 1991, an
      effectiveness study of vaccine Heberbiovac HB was conducted in 2 groups of
      physically and mentally-handicapped (A = 10 microg y B = 5 microg). The study was
      approved by the Committees of Medical Ethics and Revision of "Pedro Kouri"
      Tropical Medicine Institute and of the Center of Genetic Engineering and
      Biotechnology of the City of Havana; good clinical practice were followed and the
      ethical principles of Helsinki Declaration were respected for. The vaccination
      schedule at 0, 1 and 6 months was used in which children negative to hepatitis B 
      virus surface antigen and to hepatitis B virus surface antigen antibody were
      included. The subjects were studied from the clinical and serological viewpoints 
      up to 14 years after the implementation of the aforementioned vaccine schedule.
      RESULTS: one year after the beginning of the vaccination, there was full
      seroprotection in both groups. After 14 years of follow-up, none of the subjects 
      was positive to hepatitis B virus surface antigen, neither were they affected by 
      acute hepatitis B, which meant 100 % individual protection. CONCLUSIONS: the
      immunogenic power of Heberbiovac HB vaccine was high and its protective efficacy 
      was 100% in physically and mentally-handicapped children according to the results
      of the clinical and serological follow-up extending up to 14 years after the
      implementation of the primary vaccination schedule. These results are achieved
      for the first time for this kind of vaccine.
FAU - Pedroso Flaquet, Placido
AU  - Pedroso Flaquet P
AD  - Instituto de Medicina Tropical Pedro Kouri, Ciudad de La Habana, Cuba.
      placido@ipk.sld.cu
FAU - Diaz Gonzalez, Manuel
AU  - Diaz Gonzalez M
FAU - Rodriguez Lay, Licel
AU  - Rodriguez Lay L
LA  - spa
PT  - Journal Article
TT  - Eficacia protectora de la vacuna Heberbiovac HB a diferentes dosis en ninos
      impedidos fisicos y mentales.
PL  - Cuba
TA  - Rev Cubana Med Trop
JT  - Revista cubana de medicina tropical
JID - 0074364
RN  - 0 (Vaccines, DNA)
RN  - 0 (heberbiovac-HB)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - *Disabled Children
MH  - Hepatitis B/*prevention & control
MH  - Humans
MH  - *Persons with Mental Disabilities
MH  - Time Factors
MH  - Vaccines, DNA/*administration & dosage
EDAT- 2010/01/01 00:00
MHDA- 2013/04/02 06:00
CRDT- 2013/02/26 06:00
PHST- 2013/02/26 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2013/04/02 06:00 [medline]
PST - ppublish
SO  - Rev Cubana Med Trop. 2010 Jan-Apr;62(1):58-64.


PMID- 23186877
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121129
LR  - 20121128
IS  - 1937-7010 (Print)
IS  - 1937-7010 (Linking)
VI  - 12
IP  - 9
DP  - 2010 Sep 1
TI  - The AMA Code of Medical Ethics' Opinions on Quarantine and Physician Duty to
      Treat.
PG  - 717-8
LID - 10.1001/virtualmentor.2010.12.9.coet1-1009 [doi]
LID - virtualmentor.2010.12.9.coet1-1009 [pii]
LA  - eng
PT  - Journal Article
DEP - 20100901
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2012/11/29 06:00
PHST- 2012/11/29 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - virtualmentor.2010.12.9.coet1-1009 [pii]
AID - 10.1001/virtualmentor.2010.12.9.coet1-1009 [doi]
PST - epublish
SO  - Virtual Mentor. 2010 Sep 1;12(9):717-8. doi:
      10.1001/virtualmentor.2010.12.9.coet1-1009.


PMID- 23186848
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121129
LR  - 20121128
IS  - 1937-7010 (Print)
IS  - 1937-7010 (Linking)
VI  - 12
IP  - 8
DP  - 2010 Aug 1
TI  - The AMA Code of Medical Ethics' Opinions on Respect for Civil and Human Rights.
PG  - 644
LID - 10.1001/virtualmentor.2010.12.8.coet1-1008 [doi]
LID - virtualmentor.2010.12.8.coet1-1008 [pii]
LA  - eng
PT  - Journal Article
DEP - 20100801
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2012/11/29 06:00
PHST- 2012/11/29 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - virtualmentor.2010.12.8.coet1-1008 [pii]
AID - 10.1001/virtualmentor.2010.12.8.coet1-1008 [doi]
PST - epublish
SO  - Virtual Mentor. 2010 Aug 1;12(8):644. doi:
      10.1001/virtualmentor.2010.12.8.coet1-1008.


PMID- 23186822
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121129
LR  - 20121128
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 12
IP  - 12
DP  - 2010 Dec 1
TI  - Blepharoplasty in asian patients-ethnic and ethical implications.
PG  - 946-9
LID - 10.1001/virtualmentor.2010.12.12.msoc1-1012 [doi]
LID - virtualmentor.2010.12.12.msoc1-1012 [pii]
FAU - Motaparthi, Kiran
AU  - Motaparthi K
AD  - Baylor College of Medicine in Houston, Texas.
LA  - eng
PT  - Journal Article
DEP - 20101201
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2012/11/29 06:00
PHST- 2012/11/29 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - virtualmentor.2010.12.12.msoc1-1012 [pii]
AID - 10.1001/virtualmentor.2010.12.12.msoc1-1012 [doi]
PST - epublish
SO  - Virtual Mentor. 2010 Dec 1;12(12):946-9. doi:
      10.1001/virtualmentor.2010.12.12.msoc1-1012.


PMID- 23186817
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121129
LR  - 20121128
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 12
IP  - 12
DP  - 2010 Dec 1
TI  - The AMA Code of Medical Ethics' Opinion on Reporting Impaired Drivers.
PG  - 928-9
LID - 10.1001/virtualmentor.2010.12.12.coet2-1012 [doi]
LID - virtualmentor.2010.12.12.coet2-1012 [pii]
LA  - eng
PT  - Journal Article
DEP - 20101201
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2012/11/29 06:00
PHST- 2012/11/29 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - virtualmentor.2010.12.12.coet2-1012 [pii]
AID - 10.1001/virtualmentor.2010.12.12.coet2-1012 [doi]
PST - epublish
SO  - Virtual Mentor. 2010 Dec 1;12(12):928-9. doi:
      10.1001/virtualmentor.2010.12.12.coet2-1012.


PMID- 23186816
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121129
LR  - 20121128
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 12
IP  - 12
DP  - 2010 Dec 1
TI  - The AMA Code of Medical Ethics' Opinions on the Sale and Dispensing of
      Health-Related Products.
PG  - 925-7
LID - 10.1001/virtualmentor.2010.12.12.coet1-1012 [doi]
LID - virtualmentor.2010.12.12.coet1-1012 [pii]
LA  - eng
PT  - Journal Article
DEP - 20101201
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2012/11/29 06:00
PHST- 2012/11/29 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - virtualmentor.2010.12.12.coet1-1012 [pii]
AID - 10.1001/virtualmentor.2010.12.12.coet1-1012 [doi]
PST - epublish
SO  - Virtual Mentor. 2010 Dec 1;12(12):925-7. doi:
      10.1001/virtualmentor.2010.12.12.coet1-1012.


PMID- 23186811
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121129
LR  - 20121128
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 12
IP  - 12
DP  - 2010 Dec 1
TI  - More than meets the eye-ethics in modern ophthalmology.
PG  - 911-2
LID - 10.1001/virtualmentor.2010.12.12.fred1-1012 [doi]
LID - virtualmentor.2010.12.12.fred1-1012 [pii]
FAU - Reddy, Ashvini K
AU  - Reddy AK
AD  - Department of Ophthalmology, Baylor College of Medicine, Houston, Texas.
LA  - eng
PT  - Journal Article
DEP - 20101201
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2012/11/29 06:00
PHST- 2012/11/29 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - virtualmentor.2010.12.12.fred1-1012 [pii]
AID - 10.1001/virtualmentor.2010.12.12.fred1-1012 [doi]
PST - epublish
SO  - Virtual Mentor. 2010 Dec 1;12(12):911-2. doi:
      10.1001/virtualmentor.2010.12.12.fred1-1012.


PMID- 23186791
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121129
LR  - 20121128
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 12
IP  - 11
DP  - 2010 Nov 1
TI  - The AMA Code of Medical Ethics' Opinions on Using Drugs and Surgery for Purposes 
      Other than Treatment.
PG  - 860-3
LID - 10.1001/virtualmentor.2010.12.11.coet1-1011 [doi]
LID - virtualmentor.2010.12.11.coet1-1011 [pii]
LA  - eng
PT  - Journal Article
DEP - 20101101
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2012/11/29 06:00
PHST- 2012/11/29 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - virtualmentor.2010.12.11.coet1-1011 [pii]
AID - 10.1001/virtualmentor.2010.12.11.coet1-1011 [doi]
PST - epublish
SO  - Virtual Mentor. 2010 Nov 1;12(11):860-3. doi:
      10.1001/virtualmentor.2010.12.11.coet1-1011.


PMID- 23186790
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121129
LR  - 20121128
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 12
IP  - 11
DP  - 2010 Nov 1
TI  - The ethics of diagnosing nonepileptic seizures with placebo infusion.
PG  - 854-9
LID - 10.1001/virtualmentor.2010.12.11.ccas3-1011 [doi]
LID - virtualmentor.2010.12.11.ccas3-1011 [pii]
FAU - Bernat, James L
AU  - Bernat JL
AD  - Dartmouth Medical School and Dartmouth-Hitchcock Medical Center in Hanover, New
      Hampshire.
LA  - eng
PT  - Journal Article
DEP - 20101101
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2012/11/29 06:00
PHST- 2012/11/29 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - virtualmentor.2010.12.11.ccas3-1011 [pii]
AID - 10.1001/virtualmentor.2010.12.11.ccas3-1011 [doi]
PST - epublish
SO  - Virtual Mentor. 2010 Nov 1;12(11):854-9. doi:
      10.1001/virtualmentor.2010.12.11.ccas3-1011.


PMID- 23186737
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121129
LR  - 20121128
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 12
IP  - 10
DP  - 2010 Oct 1
TI  - AMA Code of Medical Ethics' Opinion on Disparities in Health Care.
PG  - 790-1
LID - 10.1001/virtualmentor.2010.12.10.coet1-1010 [doi]
LID - virtualmentor.2010.12.10.coet1-1010 [pii]
LA  - eng
PT  - Journal Article
DEP - 20101001
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2012/11/29 06:00
PHST- 2012/11/29 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - virtualmentor.2010.12.10.coet1-1010 [pii]
AID - 10.1001/virtualmentor.2010.12.10.coet1-1010 [doi]
PST - epublish
SO  - Virtual Mentor. 2010 Oct 1;12(10):790-1. doi:
      10.1001/virtualmentor.2010.12.10.coet1-1010.


PMID- 23186733
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121129
LR  - 20121128
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 12
IP  - 10
DP  - 2010 Oct 1
TI  - New clinical powers, new ethical questions.
PG  - 775-7
LID - 10.1001/virtualmentor.2010.12.10.fred1-1010 [doi]
LID - virtualmentor.2010.12.10.fred1-1010 [pii]
FAU - Anesi, George L
AU  - Anesi GL
AD  - Case Western Reserve University School of Medicine, Cleveland, Ohio.
LA  - eng
PT  - Journal Article
DEP - 20101001
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2012/11/29 06:00
PHST- 2012/11/29 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - virtualmentor.2010.12.10.fred1-1010 [pii]
AID - 10.1001/virtualmentor.2010.12.10.fred1-1010 [doi]
PST - epublish
SO  - Virtual Mentor. 2010 Oct 1;12(10):775-7. doi:
      10.1001/virtualmentor.2010.12.10.fred1-1010.


PMID- 23182203
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121128
LR  - 20121127
IS  - 1937-7010 (Print)
IS  - 1937-7010 (Linking)
VI  - 12
IP  - 7
DP  - 2010 Jul 1
TI  - The AMA Code of Medical Ethics Opinions on Seriously Ill Newborns and
      Do-Not-Resuscitate Orders.
PG  - 554-7
LID - 10.1001/virtualmentor.2010.12.7.coet1-1007 [doi]
LID - virtualmentor.2010.12.7.coet1-1007 [pii]
LA  - eng
PT  - Journal Article
DEP - 20100701
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2012/11/28 06:00
PHST- 2012/11/28 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - virtualmentor.2010.12.7.coet1-1007 [pii]
AID - 10.1001/virtualmentor.2010.12.7.coet1-1007 [doi]
PST - epublish
SO  - Virtual Mentor. 2010 Jul 1;12(7):554-7. doi:
      10.1001/virtualmentor.2010.12.7.coet1-1007.


PMID- 23158454
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121120
LR  - 20121119
IS  - 1937-7010 (Print)
IS  - 1937-7010 (Linking)
VI  - 12
IP  - 6
DP  - 2010 Jun 1
TI  - Unwitting partners in death-the ethics of teamwork in disaster management.
PG  - 495-501
LID - 10.1001/virtualmentor.2010.12.6.oped1-1006 [doi]
LID - virtualmentor.2010.12.6.oped1-1006 [pii]
FAU - Larkin, Gregory Luke
AU  - Larkin GL
AD  - Yale University School of Medicine in New Haven, Connecticut.
LA  - eng
PT  - Journal Article
DEP - 20100601
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2012/11/20 06:00
PHST- 2012/11/20 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - virtualmentor.2010.12.6.oped1-1006 [pii]
AID - 10.1001/virtualmentor.2010.12.6.oped1-1006 [doi]
PST - epublish
SO  - Virtual Mentor. 2010 Jun 1;12(6):495-501. doi:
      10.1001/virtualmentor.2010.12.6.oped1-1006.


PMID- 23158446
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121120
LR  - 20121119
IS  - 1937-7010 (Print)
IS  - 1937-7010 (Linking)
VI  - 12
IP  - 6
DP  - 2010 Jun 1
TI  - AMA Code of Medical Ethics' Opinion on Physician Duty to Treat.
PG  - 459
LID - 10.1001/virtualmentor.2010.12.6.coet1-1006 [doi]
LID - virtualmentor.2010.12.6.coet1-1006 [pii]
LA  - eng
PT  - Journal Article
DEP - 20100601
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2012/11/20 06:00
PHST- 2012/11/20 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - virtualmentor.2010.12.6.coet1-1006 [pii]
AID - 10.1001/virtualmentor.2010.12.6.coet1-1006 [doi]
PST - epublish
SO  - Virtual Mentor. 2010 Jun 1;12(6):459. doi:
      10.1001/virtualmentor.2010.12.6.coet1-1006.


PMID- 23158445
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121120
LR  - 20121119
IS  - 1937-7010 (Print)
IS  - 1937-7010 (Linking)
VI  - 12
IP  - 6
DP  - 2010 Jun 1
TI  - Preparing for the Unexpected-Teaching ER Ethics.
PG  - 455-8
LID - 10.1001/virtualmentor.2010.12.6.medu1-1006 [doi]
LID - virtualmentor.2010.12.6.medu1-1006 [pii]
FAU - Edwards, Kelly A
AU  - Edwards KA
AD  - Department of Bioethics and Humanities at the University of Washington School of 
      Medicine in Seattle and the Institute for Public Health Genetics.
FAU - Robey, Thomas
AU  - Robey T
LA  - eng
PT  - Journal Article
DEP - 20100601
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2012/11/20 06:00
PHST- 2012/11/20 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - virtualmentor.2010.12.6.medu1-1006 [pii]
AID - 10.1001/virtualmentor.2010.12.6.medu1-1006 [doi]
PST - epublish
SO  - Virtual Mentor. 2010 Jun 1;12(6):455-8. doi:
      10.1001/virtualmentor.2010.12.6.medu1-1006.


PMID- 23158441
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121120
LR  - 20121119
IS  - 1937-7010 (Print)
IS  - 1937-7010 (Linking)
VI  - 12
IP  - 6
DP  - 2010 Jun 1
TI  - Keeping Ethics Alive in the ED.
PG  - 437-9
LID - 10.1001/virtualmentor.2010.12.6.fred1-1006 [doi]
LID - virtualmentor.2010.12.6.fred1-1006 [pii]
FAU - Robey, Thomas
AU  - Robey T
AD  - Yale-New Haven Hospital, New Haven, CT.
LA  - eng
PT  - Journal Article
DEP - 20100601
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2012/11/20 06:00
PHST- 2012/11/20 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - virtualmentor.2010.12.6.fred1-1006 [pii]
AID - 10.1001/virtualmentor.2010.12.6.fred1-1006 [doi]
PST - epublish
SO  - Virtual Mentor. 2010 Jun 1;12(6):437-9. doi:
      10.1001/virtualmentor.2010.12.6.fred1-1006.


PMID- 23158389
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121120
LR  - 20121119
IS  - 1937-7010 (Print)
IS  - 1937-7010 (Linking)
VI  - 12
IP  - 5
DP  - 2010 May 1
TI  - Ethical issues in face transplantation.
PG  - 378-82
LID - 10.1001/virtualmentor.2010.12.5.jdsc1-1005 [doi]
LID - virtualmentor.2010.12.5.jdsc1-1005 [pii]
FAU - Vercler, Christian J
AU  - Vercler CJ
AD  - Harvard Combined Residency in Plastic Surgery in Boston and Clinical ethics at
      Emory University.
LA  - eng
PT  - Journal Article
DEP - 20100501
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2012/11/20 06:00
PHST- 2012/11/20 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - virtualmentor.2010.12.5.jdsc1-1005 [pii]
AID - 10.1001/virtualmentor.2010.12.5.jdsc1-1005 [doi]
PST - epublish
SO  - Virtual Mentor. 2010 May 1;12(5):378-82. doi:
      10.1001/virtualmentor.2010.12.5.jdsc1-1005.


PMID- 23158388
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121120
LR  - 20121119
IS  - 1937-7010 (Print)
IS  - 1937-7010 (Linking)
VI  - 12
IP  - 5
DP  - 2010 May 1
TI  - AMA Code of Medical Ethics' Opinion on Physician Advertising.
PG  - 376-7
LID - 10.1001/virtualmentor.2010.12.5.coet1-1005 [doi]
LID - virtualmentor.2010.12.5.coet1-1005 [pii]
LA  - eng
PT  - Journal Article
DEP - 20100501
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2012/11/20 06:00
PHST- 2012/11/20 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - virtualmentor.2010.12.5.coet1-1005 [pii]
AID - 10.1001/virtualmentor.2010.12.5.coet1-1005 [doi]
PST - epublish
SO  - Virtual Mentor. 2010 May 1;12(5):376-7. doi:
      10.1001/virtualmentor.2010.12.5.coet1-1005.


PMID- 23148833
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121119
LR  - 20121115
IS  - 1937-7010 (Print)
IS  - 1937-7010 (Linking)
VI  - 12
IP  - 4
DP  - 2010 Apr 1
TI  - AMA Code of Medical Ethics' Opinion on Respect for All Patients.
PG  - 286
LID - 10.1001/virtualmentor.2010.12.4.code1-1004 [doi]
LID - virtualmentor.2010.12.4.code1-1004 [pii]
LA  - eng
PT  - Journal Article
DEP - 20100401
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2012/11/15 06:00
PHST- 2012/11/15 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - virtualmentor.2010.12.4.code1-1004 [pii]
AID - 10.1001/virtualmentor.2010.12.4.code1-1004 [doi]
PST - epublish
SO  - Virtual Mentor. 2010 Apr 1;12(4):286. doi:
      10.1001/virtualmentor.2010.12.4.code1-1004.


PMID- 23140868
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121119
LR  - 20121112
IS  - 1937-7010 (Print)
IS  - 1937-7010 (Linking)
VI  - 12
IP  - 3
DP  - 2010 Mar 1
TI  - Global health ethics and professionalism education at medical schools.
PG  - 197-201
LID - 10.1001/virtualmentor.2010.12.3.jdsc2-1003 [doi]
LID - virtualmentor.2010.12.3.jdsc2-1003 [pii]
FAU - Parikh, Sujal M
AU  - Parikh SM
AD  - Third-year medical student at the University of Michigan Medical School. He
      serves on the internal advisory council for the University of Michigan Center for
      Global Health.
LA  - eng
PT  - Journal Article
DEP - 20100301
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2012/11/13 06:00
PHST- 2012/11/13 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - virtualmentor.2010.12.3.jdsc2-1003 [pii]
AID - 10.1001/virtualmentor.2010.12.3.jdsc2-1003 [doi]
PST - epublish
SO  - Virtual Mentor. 2010 Mar 1;12(3):197-201. doi:
      10.1001/virtualmentor.2010.12.3.jdsc2-1003.


PMID- 23140866
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121119
LR  - 20121112
IS  - 1937-7010 (Print)
IS  - 1937-7010 (Linking)
VI  - 12
IP  - 3
DP  - 2010 Mar 1
TI  - AMA Code of Medical Ethics ' Opinion International Research.
PG  - 190-1
LID - 10.1001/virtualmentor.2010.12.3.code1-1003 [doi]
LID - virtualmentor.2010.12.3.code1-1003 [pii]
LA  - eng
PT  - Journal Article
DEP - 20100301
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2012/11/13 06:00
PHST- 2012/11/13 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - virtualmentor.2010.12.3.code1-1003 [pii]
AID - 10.1001/virtualmentor.2010.12.3.code1-1003 [doi]
PST - epublish
SO  - Virtual Mentor. 2010 Mar 1;12(3):190-1. doi:
      10.1001/virtualmentor.2010.12.3.code1-1003.


PMID- 23140863
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121119
LR  - 20121112
IS  - 1937-7010 (Print)
IS  - 1937-7010 (Linking)
VI  - 12
IP  - 3
DP  - 2010 Mar 1
TI  - Applying themes from research ethics to international education partnerships.
PG  - 171-8
LID - 10.1001/virtualmentor.2010.12.3.medu1-1003 [doi]
LID - virtualmentor.2010.12.3.medu1-1003 [pii]
FAU - Philpott, Jane
AU  - Philpott J
AD  - Chief of family medicine at Markham Stouffville Hospital and assistant professor 
      in the University of Toronto's Department of Family & Community Medicine.
LA  - eng
PT  - Journal Article
DEP - 20100301
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2012/11/13 06:00
PHST- 2012/11/13 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - virtualmentor.2010.12.3.medu1-1003 [pii]
AID - 10.1001/virtualmentor.2010.12.3.medu1-1003 [doi]
PST - epublish
SO  - Virtual Mentor. 2010 Mar 1;12(3):171-8. doi:
      10.1001/virtualmentor.2010.12.3.medu1-1003.


PMID- 23140859
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121119
LR  - 20121112
IS  - 1937-7010 (Print)
IS  - 1937-7010 (Linking)
VI  - 12
IP  - 3
DP  - 2010 Mar 1
TI  - Global health ethics at home and abroad.
PG  - 146-8
LID - 10.1001/virtualmentor.2010.12.3.fred1-1003 [doi]
LID - virtualmentor.2010.12.3.fred1-1003 [pii]
FAU - Weinberg, Jennifer L
AU  - Weinberg JL
AD  - University of Pennsylvania.
LA  - eng
PT  - Journal Article
DEP - 20100301
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2012/11/13 06:00
PHST- 2012/11/13 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - virtualmentor.2010.12.3.fred1-1003 [pii]
AID - 10.1001/virtualmentor.2010.12.3.fred1-1003 [doi]
PST - epublish
SO  - Virtual Mentor. 2010 Mar 1;12(3):146-8. doi:
      10.1001/virtualmentor.2010.12.3.fred1-1003.


PMID- 23140814
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121119
LR  - 20121112
IS  - 1937-7010 (Print)
IS  - 1937-7010 (Linking)
VI  - 12
IP  - 2
DP  - 2010 Feb 1
TI  - AMA Code of Medical Ethics ' Opinions on Patenting Procedures and Devices.
PG  - 96
LID - 10.1001/virtualmentor.2010.12.2.code1-1002 [doi]
LID - virtualmentor.2010.12.2.code1-1002 [pii]
LA  - eng
PT  - Journal Article
DEP - 20100201
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2012/11/13 06:00
PHST- 2012/11/13 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - virtualmentor.2010.12.2.code1-1002 [pii]
AID - 10.1001/virtualmentor.2010.12.2.code1-1002 [doi]
PST - epublish
SO  - Virtual Mentor. 2010 Feb 1;12(2):96. doi:
      10.1001/virtualmentor.2010.12.2.code1-1002.


PMID- 23140813
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121119
LR  - 20121112
IS  - 1937-7010 (Print)
IS  - 1937-7010 (Linking)
VI  - 12
IP  - 2
DP  - 2010 Feb 1
TI  - A patient-centered, ethical approach to medical device innovation.
PG  - 91-5
LID - 10.1001/virtualmentor.2010.12.2.medu1-1002 [doi]
LID - virtualmentor.2010.12.2.medu1-1002 [pii]
FAU - Chao, Kevin Z
AU  - Chao KZ
AD  - senior resident in neurosurgery at Stanford University School of Medicine in Palo
      Alto, and a fellow in Stanford's Biodesign Program.
FAU - Riskin, Daniel J
AU  - Riskin DJ
FAU - Krummel, Thomas M
AU  - Krummel TM
LA  - eng
PT  - Journal Article
DEP - 20100201
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2012/11/13 06:00
PHST- 2012/11/13 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - virtualmentor.2010.12.2.medu1-1002 [pii]
AID - 10.1001/virtualmentor.2010.12.2.medu1-1002 [doi]
PST - epublish
SO  - Virtual Mentor. 2010 Feb 1;12(2):91-5. doi:
      10.1001/virtualmentor.2010.12.2.medu1-1002.


PMID- 23140779
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121119
LR  - 20121112
IS  - 1937-7010 (Print)
IS  - 1937-7010 (Linking)
VI  - 12
IP  - 1
DP  - 2010 Jan 1
TI  - AMA Code of Medical Ethics Opinion on Nurses.
PG  - 23
LID - 10.1001/virtualmentor.2010.12.1.code1-1001 [doi]
LID - virtualmentor.2010.12.1.code1-1001 [pii]
LA  - eng
PT  - Journal Article
DEP - 20100101
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2012/11/13 06:00
PHST- 2012/11/13 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - virtualmentor.2010.12.1.code1-1001 [pii]
AID - 10.1001/virtualmentor.2010.12.1.code1-1001 [doi]
PST - epublish
SO  - Virtual Mentor. 2010 Jan 1;12(1):23. doi:
      10.1001/virtualmentor.2010.12.1.code1-1001.


PMID- 23074401
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121018
LR  - 20211021
IS  - 1915-7398 (Print)
IS  - 1915-7398 (Linking)
VI  - 10
IP  - 23
DP  - 2010
TI  - Gene expression profiling for guiding adjuvant chemotherapy decisions in women
      with early breast cancer: an evidence-based and economic analysis.
PG  - 1-57
AB  - UNLABELLED: In February 2010, the Medical Advisory Secretariat (MAS) began work
      on evidence-based reviews of published literature surrounding three
      pharmacogenomic tests. This project came about when Cancer Care Ontario (CCO)
      asked MAS to provide evidence-based analyses on the effectiveness and
      cost-effectiveness of three oncology pharmacogenomic tests currently in use in
      Ontario.Evidence-based analyses have been prepared for each of these
      technologies. These have been completed in conjunction with internal and external
      stakeholders, including a Provincial Expert Panel on Pharmacogenomics (PEPP).
      Within the PEPP, subgroup committees were developed for each disease area. For
      each technology, an economic analysis was also completed by the Toronto Health
      Economics and Technology Assessment Collaborative (THETA) and is summarized
      within the reports.THE FOLLOWING REPORTS CAN BE PUBLICLY ACCESSED AT THE MAS
      WEBSITE AT: www.health.gov.on.ca/mas or at
      www.health.gov.on.ca/english/providers/program/mas/mas_about.htmlGENE EXPRESSION 
      PROFILING FOR GUIDING ADJUVANT CHEMOTHERAPY DECISIONS IN WOMEN WITH EARLY BREAST 
      CANCER: An Evidence-Based and Economic AnalysisEpidermal Growth Factor Receptor
      Mutation (EGFR) Testing for Prediction of Response to EGFR-Targeting Tyrosine
      Kinase Inhibitor (TKI) Drugs in Patients with Advanced Non-Small-Cell Lung
      Cancer: An Evidence-Based and Ecopnomic AnalysisK-RAS testing in Treatment
      Decisions for Advanced Colorectal Cancer: an Evidence-Based and Economic Analysis
      OBJECTIVE: To review and synthesize the available evidence regarding the
      laboratory performance, prognostic value, and predictive value of Oncotype-DX for
      the target population. CLINICAL NEED: CONDITION AND TARGET POPULATION The target 
      population of this review is women with newly diagnosed early stage (stage
      I-IIIa) invasive breast cancer that is estrogen-receptor (ER) positive and/or
      progesterone-receptor (PR) positive. Much of this review, however, is relevant
      for women with early stage (I and II) invasive breast cancer that is specifically
      ER positive, lymph node (LN) negative and human epidermal growth factor receptor 
      2 (HER-2/neu) negative. This refined population represents an estimated incident 
      population of 3,315 new breast cancers in Ontario (according to 2007 data).
      Currently it is estimated that only 15% of these women will develop a distant
      metastasis at 10 years; however, a far great proportion currently receive
      adjuvant chemotherapy, suggesting that more women are being treated with
      chemotherapy than can benefit. There is therefore a need to develop better
      prognostic and predictive tools to improve the selection of women that may
      benefit from adjuvant chemotherapy. TECHNOLOGY OF CONCERN: The Oncotype-DX Breast
      Cancer Assay (Genomic Health, Redwood City, CA) quantifies gene expression for 21
      genes in breast cancer tissue by performing reverse transcription polymerase
      chain reaction (RT-PCR) on formalin-fixed paraffin-embedded (FFPE) tumour blocks 
      that are obtained during initial surgery (lumpectomy, mastectomy, or core biopsy)
      of women with early breast cancer that is newly diagnosed. The panel of 21 genes 
      include genes associated with tumour proliferation and invasion, as well as other
      genes related to HER-2/neu expression, ER expression, and progesterone receptor
      (PR) expression. RESEARCH QUESTIONS: What is the laboratory performance of
      Oncotype-DX?How reliable is Oncotype-DX (i.e., how repeatable and reproducible is
      Oncotype-DX)?How often does Oncotype-DX fail to give a useable result?What is the
      prognostic value of Oncotype-DX?Is Oncotype-DX recurrence score associated with
      the risk of distant recurrence or death due to any cause in women with early
      breast cancer receiving tamoxifen?What is the predictive value of
      Oncotype-DX?Does Oncoytpe-DX recurrence score predict significant benefit in
      terms of improvements in 10-year distant recurrence or death due to any cause for
      women receiving tamoxifen plus chemotherapy in comparison to women receiving
      tamoxifen alone?How does Oncotype-DX compare to other known predictors of risk
      such as Adjuvant! Online?How does Oncotype-DX impact patient quality of life and 
      clinical/patient decision-making? RESEARCH METHODS: LITERATURE SEARCH: SEARCH
      STRATEGY: A literature search was performed on March 19(th), 2010 using OVID
      MEDLINE, MEDLINE In-Process and Other Non-Indexed Citations, EMBASE, the
      Cumulative Index to Nursing & Allied Health Literature (CINAHL), the Cochrane
      Library, and the International Agency for Health Technology Assessment (INAHTA)
      for studies published from January 1(st), 2006 to March 19(th), 2010. A starting 
      search date of January 1(st), 2006 was because a comprehensive systematic review 
      of Oncotype-DX was identified in preliminary literature searching. This
      systematic review, by Marchionni et al. (2008), included literature up to January
      1(st), 2007. All studies identified in the review by Marchionni et al. as well as
      those identified in updated literature searching were used to form the
      evidentiary base of this review. The quality of the overall body of evidence was 
      identified as high, moderate, low or very low according to GRADE methodology.
      INCLUSION CRITERIA: Any observational trial, controlled clinical trial,
      randomized controlled trial (RCT), meta-analysis or systematic review that
      reported on the laboratory performance, prognostic value and/or predictive value 
      of Oncotype-DX testing, or other outcome relevant to the Key Questions, specific 
      to the target population was included. EXCLUSION CRITERIA: Studies that did not
      report original data or original data analysis,Studies published in a language
      other than English,Studies reported only in abstract or as poster presentations
      (such publications were not sought nor included in this review since the MAS does
      not generally consider evidence that is not subject to peer review nor does the
      MAS consider evidence that lacks detailed description of methodology). OUTCOMES
      OF INTEREST: Outcomes of interest varied depending on the Key Question. For the
      Key Questions of prognostic and predictive value (Key Questions #2 and #3), the
      prospectively defined primary outcome was risk of 10-year distant recurrence. The
      prospectively defined secondary outcome was 10-year death due to any cause (i.e.,
      overall survival). All additional outcomes such as risk of locoregional
      recurrence or disease-free survival (DFS) were not prospectively determined for
      this review but were reported as presented in included trials; these outcomes are
      referenced as tertiary outcomes in this review. Outcomes for other Key Questions 
      (i.e., Key Questions #1, #4 and #5) were not prospectively defined due to the
      variability in endpoints relevant for these questions. SUMMARY OF FINDINGS: A
      total of 26 studies were included. Of these 26 studies, only five studies were
      relevant to the primary questions of this review (Key Questions #2 and #3). The
      following conclusions were drawn from the entire body of evidence: There is a
      lack of external validation to support the reliability of Oncotype-DX; however,
      the current available evidence derived from internal industry validation studies 
      suggests that Oncotype-DX is reliable (i.e., Oncotype-DX is repeatable and
      reproducible).Current available evidence suggests a moderate failure rate of
      Oncotype-DX testing; however, the failure rate observed across clinical trials
      included in this review is likely inflated; the current Ontario experience
      suggests an acceptably lower rate of test failure.In women with newly diagnosed
      early breast cancer (stage I-II) that is estrogen-receptor positive and/or
      progesterone-receptor positive and lymph-node negative:There is low quality
      evidence that Oncotype-DX has prognostic value in women who are being treated
      with adjuvant tamoxifen or anastrozole (the latter for postmenopausal women
      only),There is very low quality evidence that Oncotype-DX can predict which women
      will benefit from adjuvant CMF/MF chemotherapy in women being treated with
      adjuvant tamoxifen.In postmenopausal women with newly diagnosed early breast
      cancer that is estrogen-receptor positive and/or progesterone-receptor positive
      and lymph-node positive:There is low quality evidence that Oncotype-DX has
      limited prognostic value in women who are being treated with adjuvant tamoxifen
      or anastrozole,There is very low quality evidence that Oncotype-DX has limited
      predictive value for predicting which women will benefit from adjuvant CAF
      chemotherapy in women who are being treated with adjuvant tamoxifen.There are
      methodological and statistical limitations that affect both the generalizability 
      of the current available evidence, as well as the magnitude and statistical
      strength of the observed effect sizes; in particular:Of the major predictive
      trials, Oncotype-DX scores were only produced for a small subset of women (<40%
      of the original randomized population) potentially disabling the effects of
      treatment randomization and opening the possibility of selection bias;Data is not
      specific to HER-2/neu-negative women;There were limitations with multivariate
      statistical analyses.Additional trials of observational design may provide
      further validation of the prognostic and predictive value of Oncotype-DX;
      however, it is unlikely that prospective or randomized data will become available
      in the near future due to ethical, time and resource considerations.There is
      currently insufficient evidence investigating how Oncoytpe-DX compares to other
      known prognostic estimators of risk, such as Adjuvant! Online, and there is
      insufficient evidence investigating how Oncotype-DX would impact
      clinician/patient decision-making in a setting generalizable to Ontario.
CN  - Medical Advisory Secretariat
LA  - eng
PT  - Journal Article
DEP - 20101201
PL  - Canada
TA  - Ont Health Technol Assess Ser
JT  - Ontario health technology assessment series
JID - 101521610
PMC - PMC3382301
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2012/10/18 06:00
PHST- 2012/10/18 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
PST - ppublish
SO  - Ont Health Technol Assess Ser. 2010;10(23):1-57. Epub 2010 Dec 1.


PMID- 22701980
OWN - NLM
STAT- MEDLINE
DCOM- 20120913
LR  - 20120618
IS  - 0440-9043 (Print)
IS  - 0440-9043 (Linking)
VI  - 27
DP  - 2010-2011
TI  - [Strangers in the hospital? On the development of ethics and ethics committees in
      the hospital].
PG  - 105-14
FAU - Frewer, Andreas
AU  - Frewer A
AD  - Institut fur Geschichte und Ethik der Medizin der Universitat Erlangen-Nurnberg. 
      andreas.frewer@ethik.med.uni-erlangen.de
LA  - ger
PT  - Historical Article
PT  - Journal Article
TT  - Strangers in the Hospital? Zur Entwicklung von Ethik und Ethikgremien im
      Krankenhaus.
PL  - Germany
TA  - Hist Hosp
JT  - Historia hospitalium
JID - 7507133
MH  - Ethics Committees/*history
MH  - Ethics, Institutional/*history
MH  - Ethics, Medical/*history
MH  - Europe
MH  - Germany
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
EDAT- 2010/01/01 00:00
MHDA- 2012/09/14 06:00
CRDT- 2012/06/19 06:00
PHST- 2012/06/19 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2012/09/14 06:00 [medline]
PST - ppublish
SO  - Hist Hosp. 2010-2011;27:105-14.


PMID- 22624110
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2250-1541 (Print)
IS  - 1947-2714 (Linking)
VI  - 2
IP  - 1
DP  - 2010 Jan
TI  - Bilateral myopic photorefractive keratectomy in a 14-year-old boy.
PG  - 36-8
AB  - CONTEXT: Refractive surgery has been performed for more than 10 years.
      Laser-assisted intrastromal keratomileusis (LASIK) and photorefractive
      keratectomy (PRK) may be used in accommodative esotropia either in adolescent or 
      in adult patients. Some authors have shown that LASIK is safe, effective, and
      stable at 10 years follow-up post-surgery. CASE REPORT: A 14-year-old boy was
      admitted to our outpatient department on 08-01-2008. Together with his parents he
      asked for both eyes to be operated on by myopic PRK. On September 5(th) 2008 a
      myopic PRK was performed on his right eye and on September 12(th) 2008 on his
      left eye. A Bausch & Lomb Z172 excimer laser was used to perform a Planoscan
      procedure on both eyes. Uncorrected visual acuity was 1.0 after both procedures. 
      The patient did not suffer pain, haze or glare in postoperative follow-up.
      CONCLUSION: Apart from the surgical technique, the author raises questions about 
      the ethics of this procedure in a young boy.
FAU - Giuffre, Italo
AU  - Giuffre I
AD  - Department of Ophthalmology, University of Rome Tor Vergata Medical School, Rome,
      Italy.
LA  - eng
PT  - Case Reports
PL  - India
TA  - N Am J Med Sci
JT  - North American journal of medical sciences
JID - 101521411
PMC - PMC3354385
OTO - NOTNLM
OT  - Ethics
OT  - PRK
OT  - myopia
OT  - paediatrics
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2012/05/25 06:00
PHST- 2012/05/25 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
PST - ppublish
SO  - N Am J Med Sci. 2010 Jan;2(1):36-8.


PMID- 22586821
OWN - NLM
STAT- MEDLINE
DCOM- 20120531
LR  - 20191210
IS  - 1876-9055 (Print)
IS  - 1876-9055 (Linking)
VI  - 3
IP  - 4
DP  - 2010
TI  - [Drug advertising as communication between the pharmaceutical industry and the
      physician: advertisements for psychotropic drugs in the Dutch medical journal,
      Nederlands Tijdschrift voor Geneeskunde, 1900-1940].
PG  - 139-54
AB  - In this article we explore the historical development of drug advertisements for 
      psychotropic drugs in the leading Dutch medical journal from 1900 to 1940. The
      advertisements for hypnotics and sedatives, in The Nederlands Tijdschrift voor
      Geneeskunde (Dutch medical journal) reflected the changes in the vocabulary and
      image promoted by the pharmaceutical companies. In the first two decades, the
      advertisements were sober and to the point, and included the trademark, company
      name, molecular formula and therapeutic properties of the medication. The
      emphasis was on creating a scientific image of reliable symptom control for the
      therapeutic drug. In doing so, the ethical drug companies tried (successfully) to
      distinguish themselves from the producers of patent medicines. Once scientific
      credibility was established, the form and content of the advertisements changed
      significantly. In the late 1920s and 1930s drug companies embraced modern
      advertising techniques, developing a figurative language to address the changing 
      beliefs and practices of Dutch physicians. Instead of promoting therapeutic drugs
      as safe and scientific, the emphasis was on their effectiveness in comparison to 
      similar drugs. In the process, scientific information was reduced to an
      indispensable standardized minimum, whereby therapeutic drugs were advertised
      according to the latest pharmacological taxonomy rather than molecular formulas. 
      The image-making of 'ethical marketing' began during the interwar years when
      marketers applied modern advertising techniques and infotainment strategies. The 
      scanty black and white informational bulletins transitioned into colourful
      advertisements. The pharmaceutical companies employed the same medical language
      as used by physicians, so that one word or image in an advertisement would
      suffice for the physician to recognize a drug and its therapeutic properties.
      These developments show the changing relationship between the modern ethical
      pharmaceutical industry and Dutch doctors during the interwar years--from
      rapprochement towards concerted action.
FAU - van der Hoogte, Arjo Roersch
AU  - van der Hoogte AR
AD  - Universiteit Utrecht, Departement Pharmaceutische wetenschappen.
      A.RoerschVanDerHoogte@uu.nl
FAU - Pieters, Toine
AU  - Pieters T
LA  - dut
PT  - Historical Article
PT  - Journal Article
TT  - Advertenties voor hypnotica en sedativa in het Nederlands Tijdschrift voor
      Geneeskunde, 1900-1940: historische veranderingen in de vorm en inhoud van een
      informatiebron voor artsen.
PL  - Netherlands
TA  - Studium (Rotterdam)
JT  - Studium (Rotterdam, Netherlands)
JID - 101491727
RN  - 0 (Antipsychotic Agents)
MH  - Advertising/*history
MH  - Antipsychotic Agents/history
MH  - History, 20th Century
MH  - Humans
MH  - Netherlands
MH  - Periodicals as Topic/*history
MH  - Psychiatry/*history
EDAT- 2010/01/01 00:00
MHDA- 2012/06/01 06:00
CRDT- 2012/05/17 06:00
PHST- 2012/05/17 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2012/06/01 06:00 [medline]
PST - ppublish
SO  - Studium (Rotterdam). 2010;3(4):139-54.


PMID- 22533033
OWN - NLM
STAT- MEDLINE
DCOM- 20120518
LR  - 20191210
IS  - 1028-7825 (Print)
IS  - 1028-7825 (Linking)
VI  - 16
IP  - 2
DP  - 2010
TI  - Searching for otherness: the view of a novel.
PG  - 139-64
AB  - The ethical issues concerning the use of PGD (Preimplantation Genetic Diagnosis) 
      to select embryos of a particular HLA (Human Leukocyte Antigen) type are
      numerous. They arise from the potentially conflicting interests between those of 
      the pre-existing child, the subject of a treatment which may be curative, and
      those of the sibling to be created, who cannot give consent to the donation,
      together with the problem of the destruction of potentially healthy embryos. This
      essay focuses on the web of vulnerabilities affecting the parents, the sick child
      and the "saviour sibling," while addressing three areas: science, bioethics and
      literature. The novel My Sister's Keeper, by Jodi Picoult, provides the reader
      with an in-depth view of the conflicting interests and emotional problems that
      affect the Fitzgeralds, a family experiencing the pain of seeing one of their
      children dying while facing the tragic consequences of trying to save this child 
      by having another offspring.
FAU - Magalhaes, Susana
AU  - Magalhaes S
AD  - Research Centre of Bioethics, Portuguese Catholic University, Porto, Portugal.
      susanavtm@gmail.com
FAU - Carvalho, Ana Sofia
AU  - Carvalho AS
LA  - eng
PT  - Journal Article
PL  - England
TA  - Hum Reprod Genet Ethics
JT  - Human reproduction and genetic ethics
JID - 9815992
SB  - IM
MH  - Child
MH  - Child Welfare/ethics
MH  - *Commodification
MH  - *Conflict of Interest
MH  - Conflict, Psychological
MH  - Decision Making/*ethics
MH  - Emotions
MH  - Female
MH  - Histocompatibility Testing/*ethics
MH  - Humans
MH  - *Literature, Modern
MH  - *Living Donors
MH  - *Moral Obligations
MH  - *Parents/psychology
MH  - Personal Autonomy
MH  - Pregnancy
MH  - Preimplantation Diagnosis/*ethics
MH  - Reproduction
MH  - *Siblings
MH  - United Kingdom
EDAT- 2010/01/01 00:00
MHDA- 2012/05/19 06:00
CRDT- 2012/04/27 06:00
PHST- 2012/04/27 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2012/05/19 06:00 [medline]
AID - 10.1558/hrge.v16i2.139 [doi]
PST - ppublish
SO  - Hum Reprod Genet Ethics. 2010;16(2):139-64. doi: 10.1558/hrge.v16i2.139.


PMID- 22242070
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1757-790X (Electronic)
IS  - 1757-790X (Linking)
VI  - 2010
DP  - 2010
TI  - Do not resuscitate order in a patient with iatrogenic life threatening
      complications due to a bagatelle.
LID - 10.1136/bcr.10.2009.2383 [doi]
LID - bcr10.2009.2383 [pii]
AB  - A patient with a history of metastatic bronchial carcinoma and end stage heart
      disease was admitted to hospital, after an accidental fall, because of epistaxis 
      requiring nasal tamponade and blood transfusions. On day 2 the patient suffered
      from acute dyspnoea and finally respiratory and cardiac arrest. The patient was
      successfully resuscitated despite a do not resuscitate order (DNR order). A bolus
      aspiration of the nasal tamponade's gauze was discovered as the reason for the
      arrest. This case report underlines the ethical dilemma in patients with an
      otherwise undisputed DNR order when the arrest is: (1) easy to resolve but not
      easy to detect; (2) iatrogenic in nature; and (3) is occurring in an unmonitored 
      area (for example, the ward) as compared with an arrest in a well monitored area 
      (for example, the intensive care unit and operating room).
FAU - Mehlig, Annekathrin
AU  - Mehlig A
AD  - Kantonsspital Liestal, Department of Internal Medicine, Rheinstrasse 26, Liestal,
      4410, Switzerland.
FAU - Haberthuer, Christoph
AU  - Haberthuer C
LA  - eng
PT  - Journal Article
DEP - 20100113
PL  - England
TA  - BMJ Case Rep
JT  - BMJ case reports
JID - 101526291
PMC - PMC3029427
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2012/01/14 06:00
PHST- 2012/01/14 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - 10.1136/bcr.10.2009.2383 [doi]
AID - bcr10.2009.2383 [pii]
PST - ppublish
SO  - BMJ Case Rep. 2010;2010. pii: bcr10.2009.2383. doi: 10.1136/bcr.10.2009.2383.
      Epub 2010 Jan 13.


PMID- 22135523
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20220409
IS  - 2180-4303 (Electronic)
IS  - 1394-195X (Linking)
VI  - 17
IP  - 1
DP  - 2010 Jan
TI  - Prevalence and Sources of Stress among Universiti Sains Malaysia Medical
      Students.
PG  - 30-7
AB  - BACKGROUND: Being in medical school has always been regarded as highly stressful.
      Excessive stress causes physical and mental health problems. Persistent stress
      can impair students' academic achievement and personal or professional
      development. The aim of this study is to explore the nature of stress among
      medical students by determining the prevalence, sources and pattern of stress and
      the factors affecting it. METHODS: We chose a cross-sectional study design
      utilizing validated questionnaires, the 12 items General Health Questionnaire
      (GHQ-12) and Medical Student Stressor Questionnaire (MSSQ), to evaluate stress
      levels and stressors. School and ethical committee clearance were obtained prior 
      to the study. Data were analysed using SPSS version 12. RESULTS: Of the medical
      students who were administered the questionnaire, 761 (72%) respondents
      participated in this study. The prevalence of stress among the medical students
      was 29.6%. The top 10 stressors were academic-related. Prevalence of stress for
      the first, second, third, fourth and fifth year students was 26.3%, 36.5 %,
      31.4%, 35.3% and 21.9%, respectively. Year of study was the only significant
      factor affecting stress among medical students (P-value < 0.05). CONCLUSIONS: The
      prevalence of stress among medical students in USM is high. Academic-related
      problems were the major stressor among medical students. Year of study was the
      factor most significantly associated with medical students' stress. There was a
      bimodal pattern of the stress level throughout the year of study.
FAU - Yusoff, Muhamad Saiful Bahri
AU  - Yusoff MS
AD  - Department of Medical Education, School of Medical Sciences, Universiti Sains
      Malaysia Health Campus, Jalan Raja Perempuan Zainab II, 16150 Kubang Kerian,
      Kelantan, Malaysia.
FAU - Abdul Rahim, Ahmad Fuad
AU  - Abdul Rahim AF
FAU - Yaacob, Mohd Jamil
AU  - Yaacob MJ
LA  - eng
PT  - Journal Article
PL  - Malaysia
TA  - Malays J Med Sci
JT  - The Malaysian journal of medical sciences : MJMS
JID - 101126308
PMC - PMC3216143
OTO - NOTNLM
OT  - medical sciences
OT  - medical students
OT  - mental health
OT  - stress
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2011/12/03 06:00
PHST- 2009/08/23 00:00 [received]
PHST- 2009/10/09 00:00 [accepted]
PHST- 2011/12/03 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
PST - ppublish
SO  - Malays J Med Sci. 2010 Jan;17(1):30-7.


PMID- 22091332
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111123
LR  - 20211021
IS  - 0976-2825 (Electronic)
IS  - 2006-8808 (Linking)
VI  - 2
IP  - 1
DP  - 2010 Jan
TI  - The use of cyanoacrylate in surgical anastomosis: an alternative to microsurgery.
PG  - 44-8
LID - 10.4103/2006-8808.63727 [doi]
AB  - To present anastomosis with cyanoacrylate as a cheap, simple, fast, and available
      technique for anastomosis in urological, vascular, gynecological, and general
      surgical procedures. This method may in the future be a good alternative to
      microsurgery, particularly in centers where facilities are unavailable and the
      financial implication is unbearable for the patient. Cyanoacrylate is an adhesive
      or glue that is available in different chemical forms ranging from
      ethylcyanoacrylate (superglue) to Isobutylcyanoacrylate and octylcyanoacrylate
      (dermerbond), which is in clinical use. Anastomosis with cyanoacrylate requires
      the application of stay sutures, a luminal stent and the subsequent application
      of the adhesive. The adhesives with lower molecular weights produce a rigid and
      patent region of anastomosis, while the higher molecular compounds produce a
      consistency close to the normal tissue. This technique presents a surgical method
      that is socially, culturally, and ethically acceptable, which is affordable to a 
      larger majority of patients in our subregion. Cyanoacrylate anastomosis may in
      the future present a fast, convenient, simple, and affordable option in the
      treatment of patients requiring anastomosis. In our subregion where the
      socio-cultural, psychological, and economic burden of failed anastomosis is high,
      associated with the low per capital income, this may be a novel option for the
      management of urogynecological, vascular, neurosurgical, and general surgical
      procedures requiring either microscopic or macroscopic anastomosis.
FAU - Bot, G M
AU  - Bot GM
AD  - Department of Surgery, Jos University Teaching Hospital, Plateau State, Nigeria.
FAU - Bot, K G
AU  - Bot KG
FAU - Ogunranti, J O
AU  - Ogunranti JO
FAU - Onah, J A
AU  - Onah JA
FAU - Sule, A Z
AU  - Sule AZ
FAU - Hassan, I
AU  - Hassan I
FAU - Dung, E D
AU  - Dung ED
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Surg Tech Case Rep
JT  - Journal of surgical technique and case report
JID - 101540507
PMC - PMC3214492
OTO - NOTNLM
OT  - Alternative
OT  - anastomosis
OT  - cyanoacrylate
OT  - limited
OT  - microsurgery
OT  - resource
OT  - subregion
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2011/11/18 06:00
PHST- 2011/11/18 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - 10.4103/2006-8808.63727 [doi]
AID - JSTCR-2-44 [pii]
PST - ppublish
SO  - J Surg Tech Case Rep. 2010 Jan;2(1):44-8. doi: 10.4103/2006-8808.63727.


PMID- 22022670
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 2229-340X (Electronic)
IS  - 1319-1683 (Linking)
VI  - 17
IP  - 1
DP  - 2010 Jan
TI  - Medical students' evaluation of their exposure to the teaching of ethics.
PG  - 41-5
LID - 10.4103/1319-1683.68788 [doi]
AB  - BACKGROUND: The subject of Biomedical Ethics has become recognized as an
      essential integral component in the undergraduate curriculum of medical students.
      OBJECTIVES: (1) To review the current Biomedical Ethics Course offered at the
      College of Medicine, King Saud bin Abdul-Aziz University for Health Sciences
      (KSAU-HS). (2) To explore the perception of medical students on the different
      components of the course. MATERIALS AND METHODS: The medical students were
      requested to participate in the study at the end of the course by filling in a
      pre-designed questionnaire. A qualitative approach was used also to examine their
      perceptions about certain components of the course. RESULTS: Forty-one medical
      students participated in this study. All students expressed their strong
      agreement on the importance of their learning biomedical ethics. Their views
      about the role of Biomedical Ethics were also considered. These include
      professional development, assessment of ethical competencies, and the timing of
      the teaching of ethics. CONCLUSION: The students provided valuable comments that 
      were supported by the literature reviews. Medical Students' views of the teaching
      of the various components of biomedical ethics are important and should be sought
      in the planning of a curriculum.
FAU - Al-Haqwi, Ali I
AU  - Al-Haqwi AI
AD  - Department of Family Medicine, King Saud Bin Abdulaziz University for Health
      Sciences, Riyadh, Kingdom of Saudi Arabia.
FAU - Al-Shehri, Ali M
AU  - Al-Shehri AM
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Family Community Med
JT  - Journal of family & community medicine
JID - 100911100
PMC - PMC3195073
OTO - NOTNLM
OT  - Bioethics
OT  - bioethics curriculum
OT  - bioethics learning
OT  - bioethics teaching
OT  - professional development
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2011/10/25 06:00
PHST- 2011/10/25 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - 10.4103/1319-1683.68788 [doi]
AID - JFCM-17-41 [pii]
PST - ppublish
SO  - J Family Community Med. 2010 Jan;17(1):41-5. doi: 10.4103/1319-1683.68788.


PMID- 21932757
OWN - NLM
STAT- MEDLINE
DCOM- 20111209
LR  - 20110921
IS  - 0043-3284 (Print)
IS  - 0043-3284 (Linking)
VI  - 106
IP  - 4 Spec No
DP  - 2010
TI  - Approach to pain management in a large outpatient clinic population.
PG  - 72-8
AB  - Though it is our ethical imperative to minimize discomfort, physicians often
      struggle to manage pain effectively, mainly due to time constraints, lack of
      training, and fear of litigation regarding over-prescribing of controlled
      substances. In addition, physicians also now must face potential litigation for
      under treatment of persistent pain. This dilemma often leaves the physician with 
      a sense of insecurity and stress. We have provided a brief review of our approach
      to seek improvement in excluding substance abusers/drug diverters from those in
      need of aggressive pain management in the internal medicine outpatient clinics of
      a teaching institution. Multiple combined treatment modalities are usually
      employed, including physical interventions, evaluation and treatment of
      concomitant depression and psychosocial issues, pain modulators and analgesics,
      and consultations as indicated by clinical presentation. Experience and intuition
      are required in many cases. In our large volume, high complexity clinic setting, 
      we continue to pursue guidelines to improve and streamline screening for
      substance abuse or the potential for abuse, particularly in younger individuals. 
      In the elderly, since abuse potential is less likely and disease documentation is
      often more readily apparent, we feel relatively comfortable in initiating careful
      prescribing of opioid therapy early on. As we become more adept at our approach
      toward pain management issues, we will attempt some assessment of outcomes by
      observing changes in several parameters, including numbers of opioid
      prescriptions and comparative adequacy of pain control over time. National and
      local pain/addiction information and referral resources are available as follows:
      http:// www.nationalsubstanceabuseindex .org and http://www.wvupc.
      org/charleston/painlist.
FAU - McJunkin, Brittain
AU  - McJunkin B
AD  - West Virginia University Health Sciences Center, Charleston Division, USA.
FAU - Riley, Mary Ann
AU  - Riley MA
FAU - Lilly, J K
AU  - Lilly JK
FAU - Casto, Amy
AU  - Casto A
FAU - Bowe, Adina
AU  - Bowe A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - W V Med J
JT  - The West Virginia medical journal
JID - 0413777
RN  - 0 (Analgesics, Opioid)
SB  - IM
MH  - *Ambulatory Care
MH  - Analgesics, Opioid/*therapeutic use
MH  - Chronic Pain/*drug therapy/psychology
MH  - Depression/therapy
MH  - Exercise Therapy
MH  - Humans
MH  - Pain Management
EDAT- 2010/01/01 00:00
MHDA- 2011/12/14 06:00
CRDT- 2011/09/22 06:00
PHST- 2011/09/22 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
PST - ppublish
SO  - W V Med J. 2010;106(4 Spec No):72-8.


PMID- 21877408
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20181201
IS  - 0034-0634 (Print)
IS  - 0034-0634 (Linking)
VI  - 127
IP  - 2
DP  - 2010
TI  - [Catalonian surgery in the twentieh century].
PG  - 227-53; discussion 253-4
AB  - In order to round it off, I would like to say that the development of surgery
      during these last hundred years has been quicker than throughout the history of
      mankind. And, as far as the Catalonian Health Service is concerned, it must be
      said that its doctors have played an extremely important role not only in the
      general practice of medicine and surgery but also in all specialization. Surgeons
      here have followed the French school passionately and have widened their
      knowledge by going deeply into Central European sources. All these hospitals I
      have mentined have been, are and will be the pride of those who consider being a 
      doctor an "art". They are there to offer what society demands as the most coveted
      asset: health. Please, allow me to dedicate this speech to those from whom we
      learned not only the theory and practice of medicine but also the ethics,
      aesthetics and art of life.
FAU - Vazquez de Quevedo, Francisco
AU  - Vazquez de Quevedo F
LA  - spa
PT  - Historical Article
PT  - Lecture
TT  - Presencia Catalana en la cirugia del siglo XX.
PL  - Spain
TA  - An R Acad Nac Med (Madr)
JT  - Anales de la Real Academia Nacional de Medicina
JID - 7505188
SB  - IM
MH  - General Surgery/*history
MH  - History, 21st Century
MH  - Hospitals/history
MH  - Spain
EDAT- 2010/01/01 00:00
MHDA- 2011/12/13 00:00
CRDT- 2011/09/01 06:00
PHST- 2011/09/01 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PST - ppublish
SO  - An R Acad Nac Med (Madr). 2010;127(2):227-53; discussion 253-4.


PMID- 21836698
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1998-3794 (Electronic)
IS  - 0019-5545 (Linking)
VI  - 52
IP  - Suppl 1
DP  - 2010 Jan
TI  - A review of Indian psychiatry research and ethics.
PG  - S297-305
LID - 10.4103/0019-5545.69257 [doi]
AB  - Ethics does not seem to be a favorite topic of Indian authors. Electronic search 
      of the IJP web site could only identify six articles which were directly related 
      to ethics. One article discussed the relationship of ethics religion and
      psychiatry. Another editorial discussed the concept of responsibility in
      psychiatrists. Other editorial discussed the truth about 'truth serum' in legal
      investigations. One article discussed the ethical aspects of published research. 
      There were two articles that specifically discussed ethical aspects. This
      write-up provides some details about the ethical aspects of psychiatric practice,
      specific to India, and emphasizes the need to rediscover ethics in India.
FAU - Agarwal, A K
AU  - Agarwal AK
AD  - Retd. Professor, Department of Psychiatry, K.G's Medical College, Lucknow, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Psychiatry
JT  - Indian journal of psychiatry
JID - 0013255
PMC - PMC3146178
OTO - NOTNLM
OT  - Ethics
OT  - India
OT  - Psychiatry
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2011/08/13 06:00
PHST- 2011/08/13 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - 10.4103/0019-5545.69257 [doi]
AID - IJPsy-52-297 [pii]
PST - ppublish
SO  - Indian J Psychiatry. 2010 Jan;52(Suppl 1):S297-305. doi: 10.4103/0019-5545.69257.


PMID- 21829776
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 2229-5488 (Electronic)
IS  - 2229-3485 (Linking)
VI  - 1
IP  - 1
DP  - 2010 Jan
TI  - Human subject protection in India - is it adequate?
PG  - 15-20
AB  - India's experience in clinical trials is shorter in time than that of the
      developed countries but as in everything else in the current globalizing
      environment, business compulsions characterized by compressed timelines are
      strong persuaders to catch up. Most global pharmaceutical and biotechnology
      organizations include India in their strategic plans, Immediate implementation of
      aspects that attract benefit are an urgent necessity. Technical and ethical
      issues that remain unresolved constrain India from reaching its deserved
      potential. To take fullest advantage of the current inflow of clinical trials,
      India must adopt, without delay, an all-inclusive approach and invest in a
      widespread and comprehensive GCP-compliance programme taking into account
      India-related cultural and socioeconomic issues. The initiative should not be
      allowed to flag. Government, the pharmaceutical and biotechnological research
      industries, the medical and pharmacy profession including relevant training
      institutes, the media and the public have a stake in such investment. The
      programme should involve assessing gaps in current clinical trial compliance
      measures and possible solutions, set the field for rectification and ensure
      implementation through mandate and penalty as feasible.
FAU - Mahaluxmivala, Narges
AU  - Mahaluxmivala N
AD  - Independent Consultant - Clinical Development.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Perspect Clin Res
JT  - Perspectives in clinical research
JID - 101551517
PMC - PMC3149402
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2011/08/11 06:00
PHST- 2011/08/11 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
PST - ppublish
SO  - Perspect Clin Res. 2010 Jan;1(1):15-20.


PMID- 21829774
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20220330
IS  - 2229-5488 (Electronic)
IS  - 2229-3485 (Linking)
VI  - 1
IP  - 1
DP  - 2010 Jan
TI  - Evolution of clinical research: a history before and beyond james lind.
PG  - 6-10
AB  - The evolution of clinical research traverses a long and fascinating journey. From
      the first recorded trial of legumes in biblical times to the first randomized
      controlled of trial of streptomycin in 1946, the history of clinical trial covers
      a wide variety of challenges - scientific, ethical and regulatory. The famous
      1747 scurvy trial conducted by James Lind contained most elements of a controlled
      trial. The UK Medical Research Council's (MRC) trial of patulin for common cold
      in 1943 was the first double blind controlled trial. This paved the way for the
      first randomized control trial of streptomycin in pulmonary tuberculosis carried 
      out in 1946 by MRC of the UK. This landmark trial was a model of meticulousness
      in design and implementation, with systematic enrolment criteria and data
      collection compared with the ad hoc nature of other contemporary research. Over
      the years, as the discipline of controlled trials grew in sophistication and
      influence, the streptomycin trial continues to be referred to as ground breaking.
      The ethical advances in human protection include several milestones - Nuremberg
      Code, Declaration of Helsinki, Belmont Report, and 1996, International Conference
      on Harmonization Good Clinical Practice guidance. In parallel to ethical
      guidelines, clinical trials started to become embodied in regulation as
      government authorities began recognizing a need for controlling medical therapies
      in the early 20th century. As the scientific advances continue to occur, there
      will be new ethical and regulatory challenges requiring dynamic updates in
      ethical and legal framework of clinical trials.
FAU - Bhatt, Arun
AU  - Bhatt A
AD  - President, Clininvent Research Pvt Ltd, Mumbai, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Perspect Clin Res
JT  - Perspectives in clinical research
JID - 101551517
PMC - PMC3149409
OTO - NOTNLM
OT  - Clinical Trial
OT  - GCP
OT  - History
OT  - James Lind
OT  - Randomization
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2011/08/11 06:00
PHST- 2011/08/11 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
PST - ppublish
SO  - Perspect Clin Res. 2010 Jan;1(1):6-10.


PMID- 21799637
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 0976-7819 (Electronic)
IS  - 0976-7800 (Linking)
VI  - 1
IP  - 1
DP  - 2010 Jan
TI  - Mid-career blues in healthcare workers: A physiological approach in ethical
      management.
PG  - 35-7
LID - 10.4103/0976-7800.66994 [doi]
FAU - Pakkala, Amrith
AU  - Pakkala A
AD  - Department of Physiology, PES Institute of Medical Sciences and Research, Kuppam,
      Andhra Pradesh, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Midlife Health
JT  - Journal of mid-life health
JID - 101552746
PMC - PMC3139262
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2011/07/30 06:00
PHST- 2011/07/30 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - 10.4103/0976-7800.66994 [doi]
AID - JMH-1-35 [pii]
PST - ppublish
SO  - J Midlife Health. 2010 Jan;1(1):35-7. doi: 10.4103/0976-7800.66994.


PMID- 21799552
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 0975-1564 (Electronic)
IS  - 0253-7176 (Linking)
VI  - 32
IP  - 1
DP  - 2010 Jan
TI  - Comprehensibility of translated informed consent documents used in clinical
      research in psychiatry.
PG  - 7-12
LID - 10.4103/0253-7176.70517 [doi]
AB  - BACKGROUND: Informed consent forms are required in all clinical trials which are 
      approved by an independent Ethics Committee before practical use in the trials.
      However, how much the average subject actually understands of the information
      contained in these informed consent forms is uncertain. AIM: In a cross sectional
      study, the translated informed consent forms used in psychiatric clinical trials 
      were assessed with respect to their ease of readability. MATERIALS AND METHODS:
      We analyzed 30 informed consent forms translated from English to Hindi used in
      multinational and multicentre psychiatric clinical trials sponsored by different 
      sponsors. We examined consent forms for readability scores and factors that might
      relate to readability. RESULTS: The mean readability score for the informed
      consent forms, determined by the Flesch-Kincaid Grade Level Index (FKGL) was
      grade levels of 13.66. The ease of readability assessed by the Flesch Reading
      Ease Score (FRES) was 46.08 suggesting significant complexity of the texts. These
      values carry even more significance when the average years of schooling for India
      as a whole are 6.2 years. CONCLUSION: Our results show that the most informed
      consent forms were too complex to understand by an average adult subject. We
      suggest reducing this complexity and increasing the ease of readability so those 
      average subjects receive the intended information as exactly as it could be. This
      can be achieved by few simple measures like improving the deficiencies in
      translation processes, encouraging the investigators to participate while
      preparing these forms, and enhanced understanding of the site specific
      requirements, namely culture, language (dialect), general literacy rate, etc.
FAU - Jhanwar, Venu Gopal
AU  - Jhanwar VG
AD  - Deva Institute of Healthcare and Research (P) Ltd, B27/70MN, Durgakund, Varanasi 
      - 221005, India.
FAU - Bishnoi, Ram Jeevan
AU  - Bishnoi RJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Indian J Psychol Med
JT  - Indian journal of psychological medicine
JID - 7910727
PMC - PMC3137819
OTO - NOTNLM
OT  - Clinical research
OT  - informed consent document
OT  - readability
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2011/07/30 06:00
PHST- 2011/07/30 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - 10.4103/0253-7176.70517 [doi]
AID - IJPsyM-32-7 [pii]
PST - ppublish
SO  - Indian J Psychol Med. 2010 Jan;32(1):7-12. doi: 10.4103/0253-7176.70517.


PMID- 21739819
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20170214
IS  - 0840-4704 (Print)
IS  - 0840-4704 (Linking)
VI  - 23
IP  - 4
DP  - 2010 Winter
TI  - Ethical challenges in a military-deployed operational setting.
PG  - 177-82
FAU - Miller, Derek
AU  - Miller D
AD  - Derek.Miller4@forces.gc.ca
LA  - eng
LA  - fre
PT  - Journal Article
PL  - United States
TA  - Healthc Manage Forum
JT  - Healthcare management forum
JID - 8805307
MH  - Canada
MH  - *Ethics, Professional
MH  - Humans
MH  - Military Medicine/*ethics
MH  - *Military Personnel
EDAT- 2010/01/01 00:00
MHDA- 2011/09/29 06:00
CRDT- 2011/07/12 06:00
PHST- 2011/07/12 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 10.1016/j.hcmf.2010.09.003 [doi]
PST - ppublish
SO  - Healthc Manage Forum. 2010 Winter;23(4):177-82. doi: 10.1016/j.hcmf.2010.09.003.


PMID- 21686302
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120827
LR  - 20211020
IS  - 1911-2092 (Electronic)
VI  - 4
IP  - 2
DP  - 2010
TI  - The ethics of organ donation after cardiocirculatory death: Do the guidelines of 
      the Canadian Council for Donation and Transplantation measure up?
PG  - e129-33
FAU - Browne, Alister
AU  - Browne A
LA  - eng
PT  - Journal Article
DEP - 20100629
PL  - Canada
TA  - Open Med
JT  - Open medicine : a peer-reviewed, independent, open-access journal
JID - 101319172
PMC - PMC3116683
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2011/06/21 06:00
PHST- 2009/04/11 00:00 [received]
PHST- 2010/02/07 00:00 [revised]
PHST- 2010/02/21 00:00 [accepted]
PHST- 2011/06/21 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
PST - ppublish
SO  - Open Med. 2010;4(2):e129-33. Epub 2010 Jun 29.


PMID- 21661234
OWN - NLM
STAT- MEDLINE
DCOM- 20110719
LR  - 20150730
IS  - 0285-2314 (Print)
IS  - 0285-2314 (Linking)
VI  - 45
IP  - 2
DP  - 2010
TI  - [The history of drug reevaluation in Japan].
PG  - 93-100
AB  - The drug reevaluation system was established to review the quality, efficacy and 
      safety of drugs approved in the past based on current medical and pharmaceutical 
      scientific standards. There have been three reevaluations of ethical drugs in
      Japan implemented according to the approved dates. The first reevaluation started
      in 1971 and finished in 1995 for the drugs that were approved up until September 
      1967. The second reevaluation started in 1984 and finished in 1996 for the drugs 
      that were approved between October 1967 and March 1980. The new reevaluation
      system for all drugs regardless of the approval date consists of periodic
      reevaluation and Ad Hoc reevaluation. This system started in 1988 and has
      continued up to the present. Periodic reevaluation is a system where the efficacy
      and safety of drugs of all therapeutic categories are reviewed every five years
      based on literature screening. However, this system is currently suspended. Ad
      Hoc reevaluation is used to supplement periodic reevaluation and is performed at 
      the onset of an emergency or when an entire therapeutic category becomes
      roblematic. In the second reevaluation and new reevaluation system, it is harder 
      to judge which products must be reevaluated than in the first reevaluation for
      all drugs. In addition, the quality reevaluation for oral solid formulations
      based on dissolution studies started in February in 1997 and is almost finished.
FAU - Takahashi, Haruo
AU  - Takahashi H
AD  - Japan Pharmaceutical Information Center (JAPIC), Shibuya 2 chome, Shibuya-ku,
      Tokyo 150-0002.
LA  - jpn
PT  - English Abstract
PT  - Historical Article
PT  - Journal Article
PL  - Japan
TA  - Yakushigaku Zasshi
JT  - Yakushigaku zasshi
JID - 1267223
MH  - Drug Approval/history
MH  - Drug Evaluation/*history
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Japan
EDAT- 2010/01/01 00:00
MHDA- 2011/07/20 06:00
CRDT- 2011/06/14 06:00
PHST- 2011/06/14 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2011/07/20 06:00 [medline]
PST - ppublish
SO  - Yakushigaku Zasshi. 2010;45(2):93-100.


PMID- 21644432
OWN - NLM
STAT- MEDLINE
DCOM- 20110622
LR  - 20191112
IS  - 1028-7825 (Print)
IS  - 1028-7825 (Linking)
VI  - 16
IP  - 1
DP  - 2010
TI  - Is the creation of admixed embryos "an offense against human dignity"?
PG  - 87-114
AB  - The controversy over the creation of admixed human-nonhuman embryos, and
      specifically of what have been termed "cybrids," involves a range of ethical and 
      political issues. It is not reducible to a single question. This paper focuses on
      one question raised by that controversy, whether creating admixed human-nonhuman 
      entities is "an offense against human dignity. "In the last decade there has been
      sustained criticism of the use of the concept of human dignity within bioethics. 
      The concept has been criticized as "vague" and "useless." Nevertheless, the
      concept continues to be invoked in bioethical discussion and in international
      instruments. This paper defends a concept of human dignity that is coherent but
      that is wider than contemporary post-Kantian approaches. "Human dignity" is best 
      regarded as having a set of analogically related meanings, more than one of which
      is relevant to the field of bioethics. A more subtle understanding of the concept
      of human dignity can help identify what is ethically problematic in
      human-nonhuman combinations and so shed light on one aspect of the admixed embryo
      debate.
FAU - Jones, David Albert
AU  - Jones DA
AD  - Anscombe Bioethics Centre, Oxford. director@bioethics.org.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - Hum Reprod Genet Ethics
JT  - Human reproduction and genetic ethics
JID - 9815992
SB  - IM
MH  - Achievement
MH  - Animals
MH  - *Chimera
MH  - Cloning, Organism/*ethics
MH  - Embryo Research/*ethics
MH  - Embryo, Mammalian
MH  - Human Rights
MH  - Humans
MH  - *Personhood
EDAT- 2010/01/01 00:00
MHDA- 2011/06/23 06:00
CRDT- 2011/06/08 06:00
PHST- 2011/06/08 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2011/06/23 06:00 [medline]
AID - 10.1558/hrge.v16i1.87 [doi]
PST - ppublish
SO  - Hum Reprod Genet Ethics. 2010;16(1):87-114. doi: 10.1558/hrge.v16i1.87.


PMID- 21644430
OWN - NLM
STAT- MEDLINE
DCOM- 20110622
LR  - 20191112
IS  - 1028-7825 (Print)
IS  - 1028-7825 (Linking)
VI  - 16
IP  - 1
DP  - 2010
TI  - Therapeutic cloning: the ethical road to regulation. Part II: Analysing the UK
      position.
PG  - 60-73
FAU - Brown, Alistair
AU  - Brown A
AD  - McGrigors LLP, 141 Bothwell Street, Glasgow G2 7EQ, Scotland. alijbrown@gmail.com
LA  - eng
PT  - Journal Article
PL  - England
TA  - Hum Reprod Genet Ethics
JT  - Human reproduction and genetic ethics
JID - 9815992
SB  - IM
MH  - Cloning, Organism/*ethics/*legislation & jurisprudence
MH  - Embryo Research/ethics/*legislation & jurisprudence
MH  - *Government Regulation
MH  - Humans
MH  - Reproductive Techniques, Assisted/ethics/legislation & jurisprudence
MH  - Stem Cell Research/ethics/legislation & jurisprudence
MH  - United Kingdom
EDAT- 2010/01/01 00:00
MHDA- 2011/06/23 06:00
CRDT- 2011/06/08 06:00
PHST- 2011/06/08 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2011/06/23 06:00 [medline]
AID - 10.1558/hrge.v16i1.60 [doi]
PST - ppublish
SO  - Hum Reprod Genet Ethics. 2010;16(1):60-73. doi: 10.1558/hrge.v16i1.60.


PMID- 21644429
OWN - NLM
STAT- MEDLINE
DCOM- 20110622
LR  - 20191112
IS  - 1028-7825 (Print)
IS  - 1028-7825 (Linking)
VI  - 16
IP  - 1
DP  - 2010
TI  - Stem cells, nuclear transfer and respect for embryos.
PG  - 48-59
AB  - Harvesting human embryonic stem (hES) cells is a highly controversial field of
      research because it rests on the destruction of human embryos. Altering the
      procedure of nuclear transfer (NT) is suggested to generate hES cell lines
      without ethical obstacles by claiming that no embryo would be involved. While
      discussing the nature of an embryo and related central questions concerning their
      moral status and the respect they deserve, this paper argues that the entity
      created by somatic cell nuclear transfer (SCNT) or altered nuclear transfer (ANT)
      is an embryo and has the same moral status as a natural embryo. Respect for the
      embryo is expressed by the ethical principles of proportionality, probability and
      subsidiarity. This paper argues that the human embryo should only be taken for
      research with high ranking goals, which are proven in animal experimentation and 
      for which there are no alternatives. This makes ANT obsolete and shows that SCNT 
      to produce hES cells is premature at the present time.
FAU - Clausen, Jens
AU  - Clausen J
AD  - Institute for Ethics and History in Medicine, Gartenstrasse 47, 72074 Tubingen,
      Germany. jens.clausen@uni-tuebingen.de
LA  - eng
PT  - Journal Article
PL  - England
TA  - Hum Reprod Genet Ethics
JT  - Human reproduction and genetic ethics
JID - 9815992
SB  - IM
MH  - Blastocyst
MH  - Cloning, Organism/*ethics
MH  - Embryo Research/ethics
MH  - *Embryonic Stem Cells
MH  - Humans
MH  - *Moral Obligations
MH  - Nuclear Transfer Techniques/*ethics
MH  - *Value of Life
EDAT- 2010/01/01 00:00
MHDA- 2011/06/23 06:00
CRDT- 2011/06/08 06:00
PHST- 2011/06/08 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2011/06/23 06:00 [medline]
AID - 10.1558/hrge.v16i1.48 [doi]
PST - ppublish
SO  - Hum Reprod Genet Ethics. 2010;16(1):48-59. doi: 10.1558/hrge.v16i1.48.


PMID- 21644428
OWN - NLM
STAT- MEDLINE
DCOM- 20110622
LR  - 20191112
IS  - 1028-7825 (Print)
IS  - 1028-7825 (Linking)
VI  - 16
IP  - 1
DP  - 2010
TI  - Global principles, local obligations: reproductive ethics in affluent societies
      and developing countries.
PG  - 32-47
AB  - This essay is an intercultural dialogue in reproductive ethics. The paper, which 
      argues from both developed and developing world perspectives, addresses the
      question of what should be done when confronted with the possibility of giving
      birth to a severely disabled child. The author argues that such a life should not
      be considered because of the economic circumstances in most developing countries.
      This is contrary to the view sometimes advanced in affluent societies that the
      prevention of such a birth should not necessarily be considered. The author,
      however, agrees that the principle of acceptable outlook could be employed in
      both economic settings but with a variable degree of moral compliance without
      suggesting that certain lives are better than others.
FAU - Omonzejele, Peter F
AU  - Omonzejele PF
AD  - Department of Philosophy, University of Benin, Benin-City, Edo State, Nigeria.
      pomonzejele@yahoo.com
LA  - eng
PT  - Journal Article
PL  - England
TA  - Hum Reprod Genet Ethics
JT  - Human reproduction and genetic ethics
JID - 9815992
SB  - IM
MH  - Cross-Cultural Comparison
MH  - *Cultural Characteristics
MH  - *Developed Countries
MH  - *Developing Countries
MH  - *Disabled Persons
MH  - Female
MH  - Humans
MH  - Male
MH  - *Moral Obligations
MH  - Pregnancy
MH  - *Quality of Life
MH  - Reproductive Behavior/*ethics
MH  - Socioeconomic Factors
EDAT- 2010/01/01 00:00
MHDA- 2011/06/23 06:00
CRDT- 2011/06/08 06:00
PHST- 2011/06/08 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2011/06/23 06:00 [medline]
AID - 10.1558/hrge.v16i1.32 [doi]
PST - ppublish
SO  - Hum Reprod Genet Ethics. 2010;16(1):32-47. doi: 10.1558/hrge.v16i1.32.


PMID- 21594007
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1874-4311 (Electronic)
IS  - 1874-4311 (Linking)
VI  - 4
DP  - 2010 Sep 15
TI  - Patients at the centre: methodological considerations for evaluating evidence
      from health interventions involving patients use of web-based information
      systems.
PG  - 188-94
LID - 10.2174/1874431101004010188 [doi]
AB  - Building an evidence base for healthcare interventions has long been advocated as
      both professionally and ethically desirable. By supporting meaningful comparison 
      amongst different approaches, a good evidence base has been viewed as an
      important element in optimising clinical decision-making and the safety and
      quality of care. Unsurprisingly, medical research has put considerable effort
      into supporting the development of this evidence base, and the randomised
      controlled trial has become the dominant methodology. Recently however, a body of
      research has begun to question, not just this methodology per se, but also the
      extent to which the evidence it produces may marginalise individual patient
      experiences, priorities and perceptions.Simultaneously, the widespread adoption
      and utilisation of information systems (IS) in health care has also prompted
      initiatives to develop a stronger base of evidence about their impacts. These
      calls have been stimulated both by numerous system failures and research
      expressing concerns about the limitations of information systems methodologies in
      health care environments. Alongside the potential of information systems to
      produce positive, negative and unintended consequences, many measures of success,
      impact or benefit appear to have little to do with improvements in care, health
      outcomes or individual patient experiences.Combined these methodological concerns
      suggest the need for more detailed examination. This is particularly the case,
      given the prevalence within contemporary clinical and IS discourses on health
      interventions advocating the need to put the 'patient at the centre' by engaging 
      them in their own care and/or 'empowering' them through the use of information
      systems.This paper aims to contribute to these on-going debates by focusing on
      the socio-technical processes by which patients' interests and outcomes are
      measured, defined and evaluated within health interventions that involve them
      using web-based information systems. The paper outlines an integrated approach
      that aims to generate evidence about the impact of these types of health
      interventions that are meaningful at both individual patient and patient cohort
      levels.
FAU - Cummings, Elizabeth
AU  - Cummings E
AD  - eHealth Services Research Group, School of Computing and Information Systems,
      University of Tasmania, Hobart, Australia.
FAU - Turner, Paul
AU  - Turner P
LA  - eng
PT  - Journal Article
DEP - 20100915
PL  - United Arab Emirates
TA  - Open Med Inform J
JT  - The open medical informatics journal
JID - 101480483
PMC - PMC3096889
OTO - NOTNLM
OT  - Patients
OT  - evaluation
OT  - evidence
OT  - health information systems
OT  - web-based systems.
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2011/05/20 06:00
PHST- 2009/08/03 00:00 [received]
PHST- 2010/01/08 00:00 [revised]
PHST- 2010/01/12 00:00 [accepted]
PHST- 2011/05/20 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - 10.2174/1874431101004010188 [doi]
AID - TOMINFOJ-4-188 [pii]
PST - epublish
SO  - Open Med Inform J. 2010 Sep 15;4:188-94. doi: 10.2174/1874431101004010188.


PMID- 21589744
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 2228-5504 (Electronic)
IS  - 1735-9066 (Linking)
VI  - 15
IP  - 1
DP  - 2010 Winter
TI  - Respecting to patients' autonomy in viewpoint of nurses and patients in
      medical-surgical wards.
PG  - 14-9
AB  - BACKGROUND: Respect to patients' autonomy is a cornerstone of medical ethics and 
      nurses have a key role in respecting patients' autonomy. In review of Iranian
      literature, there is no study investigating the respect to patients' autonomy
      during nursing cares. The aim of the present study was to compare nurses and
      patients' perceptions regarding respecting to patients' autonomy during nursing
      care. METHODS: This study had a comparative descriptive design and conducted in
      2008. The study population was consisted of all nursing staff (n = 79) working in
      three related hospitals of Tabriz University of Medical Science using census
      sampling. Also, 187 hospitalized patients in these hospitals participated with
      convenience sampling. To assess the respecting to patients' autonomy, two
      parallel questionnaires were prepared. Data analysis was done in SPSS using
      Mann-Whitney and Kruskal-Wallis tests and Spearman correlation coefficient.
      RESULTS: Nurses reported that they respected to patients' autonomy, but patients 
      believed that their autonomy was not respected. Also, there was a significant
      statistical relation between perception of health status, need for nursing care, 
      and age of patient and their report of respect to their autonomy. CONCLUSIONS:
      There is an exiting difference in viewpoint of nurses and patients regarding
      respecting to patient autonomy. But, because of insufficient evidence more
      studies are recommended.
FAU - Rahmani, Azad
AU  - Rahmani A
AD  - School of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz,
      Iran.
FAU - Ghahramanian, Akram
AU  - Ghahramanian A
FAU - Alahbakhshian, Atefeh
AU  - Alahbakhshian A
LA  - eng
PT  - Journal Article
PL  - India
TA  - Iran J Nurs Midwifery Res
JT  - Iranian journal of nursing and midwifery research
JID - 101558775
PMC - PMC3093030
OTO - NOTNLM
OT  - Medical ethics
OT  - decision making
OT  - nursing care
OT  - personal autonomy
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2011/05/19 06:00
PHST- 2009/09/07 00:00 [received]
PHST- 2009/11/04 00:00 [accepted]
PHST- 2011/05/19 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
PST - ppublish
SO  - Iran J Nurs Midwifery Res. 2010 Winter;15(1):14-9.


PMID- 21589711
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1916-257X (Electronic)
VI  - 3
IP  - 3
DP  - 2010 Sep 28
TI  - The ethical implications of research and education in the massage therapy
      profession.
PG  - 17-9
AB  - As a therapist operating my own practice, I am constantly reminded of the ethical
      aspects of my work in dealing with situations involving clients and the everyday 
      running of my business. Professional boundaries and ethical practices are
      recognized within our profession as an important aspect of our work, as evidenced
      by mandatory classes on ethics in most U.S. states and also by the clearly stated
      ethical codes and practices set out by our professional organizations. The
      reasoning behind these measures is clear. Ethical declarations and a thorough
      understanding of them and their application are needed. They set standards of
      integrity. They help to define massage therapy as a profession and have
      significant repercussions on how massage therapists are perceived by the public.
FAU - Chunco, Rosemary
AU  - Chunco R
AD  - Shamrock Therapeutics LLC, Plano, TX, USA.
LA  - eng
PT  - Journal Article
DEP - 20100928
PL  - United States
TA  - Int J Ther Massage Bodywork
JT  - International journal of therapeutic massage & bodywork
JID - 101539415
PMC - PMC3091434
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2011/05/19 06:00
PHST- 2011/05/19 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
PST - epublish
SO  - Int J Ther Massage Bodywork. 2010 Sep 28;3(3):17-9.


PMID- 21577337
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 2035-8377 (Electronic)
IS  - 2035-8385 (Linking)
VI  - 2
IP  - 1
DP  - 2010 Jun 21
TI  - Alternative oblique head CT scanning technique reduces bone artifact and improves
      interpretability of brainstem anatomy.
PG  - e14
LID - 10.4081/ni.2010.e14 [doi]
AB  - Brainstem pathology due to infections, infarcts and tumors are common in
      developing countries, but neuroimaging technology in these resource-poor settings
      is often limited to single slice, and occasionally spiral, CT. Unlike multislice 
      CT and MRI, single slice and spiral CT are compromised by bone artifacts in the
      posterior fossa due to the dense petrous bones, often making imaging of the
      brainstem non-diagnostic. With appropriate head positioning, the petrous ridges
      can be avoided with 40 degrees sagittal oblique scans parallel to either petrous 
      ridge. We describe an alternative sagittal oblique scanning technique that
      significantly reduces brainstem CT artifacts thereby improving clarity of
      anatomy. With Institutional Ethical approval, 13 adult patients were enrolled (5 
      males; 39%). All patients had routine axial brain CT and sagittal oblique scans
      with no lesions found. Images were read by 2 readers who gave a score for amount 
      of artefact and clarity of structures in the posterior fossa. The mean artifact
      score was higher for routine axial images compared to sagittal oblique (2.92 vs. 
      1.23; P<0.0001). The mean anatomical certainty scores for the brainstem were
      significantly better in the sagittal oblique views compared to routine axial
      (1.23 vs. 2.77; P<0.0001). No difference was found between the two techniques
      with respect to the fourth ventricle or the cerebellum (axial vs. sag oblique:
      1.15 vs. 1.27; P=0.37). When using single slice CT, the sagittal oblique scanning
      technique is valuable in improving clarity of anatomy in the brainstem if axial
      images are non-diagnostic due to bone artifacts.
FAU - Kampondeni, Sam
AU  - Kampondeni S
AD  - Michigan State University, Department of Radiology, East Lansing, MI, USA;
FAU - Birbeck, Gretchen L
AU  - Birbeck GL
FAU - Oostveen, Robert J
AU  - Oostveen RJ
FAU - Hammond, Colleen
AU  - Hammond C
FAU - Potchen, Michael J
AU  - Potchen MJ
LA  - eng
PT  - Journal Article
DEP - 20100621
PL  - Switzerland
TA  - Neurol Int
JT  - Neurology international
JID - 101551564
PMC - PMC3093213
OTO - NOTNLM
OT  - artifact
OT  - brain CT.
OT  - brainstem
OT  - sagittal oblique
OT  - single slice CT
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2011/05/18 06:00
PHST- 2010/05/12 00:00 [received]
PHST- 2010/06/07 00:00 [revised]
PHST- 2010/06/09 00:00 [accepted]
PHST- 2011/05/18 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - 10.4081/ni.2010.e14 [doi]
AID - ni.2010.e14 [pii]
PST - epublish
SO  - Neurol Int. 2010 Jun 21;2(1):e14. doi: 10.4081/ni.2010.e14.


PMID- 21542212
OWN - HMD
STAT- MEDLINE
DCOM- 20110623
LR  - 20200528
IS  - 1529-3262 (Print)
IS  - 1529-3262 (Linking)
VI  - 10
IP  - 3
DP  - 2010
TI  - Emmanuel Levinas and the ontology of eating.
PG  - 34-44
AB  - This essay examines the existential philosophy of Emmanuel Levinas in relation to
      issues of food and eating. I argue that for Levinas, the act of eating is central
      to founding the ethical self, and that any understanding of Levinas's approach to
      embodiment must begin with what it means for us to ingest the outside world. Even
      in Levinas's earliest work, food is already a freighted ontological category. As 
      his ideas mature, eating is transformed from the grounding for an ethical system 
      to the system itself. The act of giving bread to another person takes its place
      as the ethical gesture par excellence. The story is not that we eat. The story is
      that we eat and develop a relationship to eating, and that relationship in turn
      helps determine our sense of ourselves in the world. Eating is the ethical event.
      The essay ends by asking how Levinas can help us answer the question, what would 
      it mean to imagine every bite I take, or give to another, as a direct engagement 
      with my own and my neighbor's existence?
FAU - Goldstein, David
AU  - Goldstein D
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - Gastronomica (Berkeley Calif)
JT  - Gastronomica : the journal of food and culture
JID - 101554255
MH  - Anthropology, Cultural/education/history
MH  - *Cooking/economics/history
MH  - *Diet/economics/ethnology/history/psychology
MH  - *Eating/ethnology/physiology/psychology
MH  - Ethics/history
MH  - *Food/economics/history
MH  - Food Supply/economics/history
MH  - History, 20th Century
MH  - *Self-Assessment
MH  - Social Identification
EDAT- 2010/01/01 00:00
MHDA- 2011/06/24 06:00
CRDT- 2011/05/06 06:00
PHST- 2011/05/06 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2011/06/24 06:00 [medline]
AID - 10.1525/gfc.2010.10.3.34 [doi]
PST - ppublish
SO  - Gastronomica (Berkeley Calif). 2010;10(3):34-44. doi: 10.1525/gfc.2010.10.3.34.


PMID- 21528099
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 1050-8422 (Print)
IS  - 1050-8422 (Linking)
VI  - 20
IP  - 5
DP  - 2010
TI  - Both Sides of the Coin: Randomization from the Perspectives of
      Physician-Investigators and Patient-Subjects.
PG  - 380-386
AB  - Randomization is the "gold standard" design for clinical research trials, and is 
      accepted as the best way to reduce bias. Although some controversy remains over
      this matter, we believe equipoise is the fundamental ethical requirement for
      conducting a randomized clinical trial. Despite much attention to the ethics of
      randomization, the moral psychology of this study design has not been explored.
      This paper analyzes the ethical tensions that arise from conducting these
      studies, and examines the moral psychology of this design from the perspectives
      of physician-investigators and patient-subjects. We conclude with a discussion of
      the practical implications of this analysis.
FAU - Yap, Tsiao Yi
AU  - Yap TY
AD  - Dr. Yap was a third-year Pediatric Hematology Oncology Fellow, Children's
      Hospital, Cleveland Clinic, Cleveland Ohio.
FAU - Kassimatis, Kathleen A
AU  - Kassimatis KA
FAU - Kodish, Eric
AU  - Kodish E
LA  - eng
GR  - R01 CA122217/CA/NCI NIH HHS/United States
GR  - R01 CA122217-04/CA/NCI NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Ethics Behav
JT  - Ethics & behavior
JID - 9102086
PMC - PMC3082146
MID - NIHMS236459
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2011/04/30 06:00
PHST- 2011/04/30 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - 10.1080/10508422.2010.491764 [doi]
PST - ppublish
SO  - Ethics Behav. 2010;20(5):380-386. doi: 10.1080/10508422.2010.491764.


PMID- 21495602
OWN - NLM
STAT- MEDLINE
DCOM- 20110629
LR  - 20110418
IS  - 1020-3397 (Print)
IS  - 1020-3397 (Linking)
VI  - 16 Suppl
DP  - 2010
TI  - Human organ and tissue transplantation in Pakistan: when a regulation makes a
      difference.
PG  - S159-66
AB  - Organ transplantation must be viewed in relation to the prevailing cultural,
      religious and economic conditions of a nation. Over the past two decades,
      Pakistan has emerged as one of the largest centres for commercial renal
      transplantation. Government efforts, supported by professional associations,
      civil society organizations and the media, along with World Health Organization
      technical assistance, have led to the development of legislation regulating this 
      practice and curbing organ trade in conformity with international guidelines.
      Although only two years have passed since the enactment of the law, there is
      evidence that conditions have significantly improved, raising hopes for ethical
      and safe organ transplantation in Pakistan. This study reviews the salient
      features of the legislation and lists the foreseeable evolving challenges and
      opportunities.
FAU - Bile, K M
AU  - Bile KM
AD  - World Health Organization, Country Office, Islamabad, Pakistan.
      bilek@pak.emro.who.int
FAU - Qureshi, J A R H
AU  - Qureshi JA
FAU - Rizvi, S A H
AU  - Rizvi SA
FAU - Naqvi, S A A
AU  - Naqvi SA
FAU - Usmani, A Q
AU  - Usmani AQ
FAU - Lashari, K A
AU  - Lashari KA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Egypt
TA  - East Mediterr Health J
JT  - Eastern Mediterranean health journal = La revue de sante de la Mediterranee
      orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit
JID - 9608387
SB  - IM
MH  - *Government Regulation
MH  - Humans
MH  - Organ Transplantation/*legislation & jurisprudence
MH  - Pakistan
MH  - Tissue Donors/ethics/*legislation & jurisprudence
EDAT- 2010/01/01 00:00
MHDA- 2011/06/30 06:00
CRDT- 2011/04/19 06:00
PHST- 2011/04/19 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2011/06/30 06:00 [medline]
PST - ppublish
SO  - East Mediterr Health J. 2010;16 Suppl:S159-66.


PMID- 21485345
OWN - NLM
STAT- MEDLINE
DCOM- 20110510
LR  - 20110412
IS  - 0002-7979 (Print)
IS  - 0002-7979 (Linking)
VI  - 77
IP  - 4
DP  - 2010 Winter
TI  - Evidence-based dentistry.
PG  - 68-80
AB  - Both panegyric and criticism of evidence-based dentistry tend to be clumsy
      because the concept is poorly defined. This analysis identifies several
      contributions to the profession that have been made under the EBD banner.
      Although the concept of clinicians integrating clinical epidemiology, the wisdom 
      of their practices, and patients' values is powerful, its implementation has been
      distorted by a too heavy emphasis of computerized searches for research findings 
      that meet the standards of academics. Although EBD advocates enjoy sharing
      anecdotal accounts of mistakes others have made, faulting others is not proof
      that one's own position is correct. There is no systematic, high-quality evidence
      that EBD is effective. The metaphor of a three-legged stool (evidence,
      experience, values, and integration) is used as an organizing principle. "Best
      evidence" has become a preoccupation among EBD enthusiasts. That overlong but
      thinly developed leg of the stool is critiqued from the perspectives of the
      criteria for evidence, the difference between internal and external validity, the
      relationship between evidence and decision making, the ambiguous meaning of
      "best," and the role of reasonable doubt. The strongest leg of the stool is
      clinical experience. Although bias exists in all observations (including searches
      for evidence), there are simple procedures that can be employed in practice to
      increase useful and objective evidence there, and there are dangers in delegating
      policy regarding allowable treatments to external groups. Patient and
      practitioner values are the shortest leg of the stool. As they are so little
      recognized, their integration in EBD is problematic and ethical tensions exist
      where paternalism privileges science over patient's self-determined best
      interests. Four potential approaches to integration are suggested, recognizing
      that there is virtually no literature on how the "seat" of the three-legged stool
      works or should work. It is likely that most dentists choose to wait for
      collective professional standards to reveal acceptable practice or follow a
      strategy of punctuated equilibrium, only switching out established practice
      habits when very conspicuous advantages are identified. Integration in medicine
      appears to follow the statistically sophisticated practice of updating estimates 
      of clinical parameters (probabilities) for diagnoses, treatments, prognoses, and 
      side-effects. This approach is likely beyond the skill or interest of clinical
      dentists and it fails to incorporate values in the integration. The use of
      decision trees to integrate both research and experiential parameters and values 
      is illustrated and it is shown that such a technique identifies why there are
      very few cases in dentistry where evidence needs to be consulted and indicates
      what such cases are.
FAU - Chambers, David W
AU  - Chambers DW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Coll Dent
JT  - The Journal of the American College of Dentists
JID - 7503057
SB  - IM
MH  - Bayes Theorem
MH  - Decision Making
MH  - Ethics, Dental
MH  - *Evidence-Based Dentistry
MH  - Humans
MH  - Observer Variation
MH  - Publication Bias
MH  - Social Values
MH  - Standard of Care
MH  - Treatment Outcome
EDAT- 2010/01/01 00:00
MHDA- 2011/05/11 06:00
CRDT- 2011/04/13 06:00
PHST- 2011/04/13 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2011/05/11 06:00 [medline]
PST - ppublish
SO  - J Am Coll Dent. 2010 Winter;77(4):68-80.


PMID- 21485344
OWN - NLM
STAT- MEDLINE
DCOM- 20110510
LR  - 20151119
IS  - 0002-7979 (Print)
IS  - 0002-7979 (Linking)
VI  - 77
IP  - 4
DP  - 2010 Winter
TI  - How dentistry should approach its problems: a vote for professionalism.
PG  - 59-67
AB  - Dentistry, like all professions, has always had ethical problems to contend with,
      including societal trust, flagrant advertising, commercialism, and access to
      care. Although the profession's interest and expertise in ethics has grown
      enormously in the last three decades, the issues facing dentistry have not really
      decreased, and perhaps have grown more problematic. Thus, despite the invaluable 
      contributions of ethical progress to the structure and function of our
      profession, this paper argues that reflective ethics by itself appears unable to 
      exact change. For change to occur, dentistry also needs a broad-based display of 
      enlightened, and ethically-driven but action-oriented professionalism. This
      existed in the 1830s when U.S. dentistry was in its early stages of becoming
      thought of as a profession. Using the lessons learned from that period of our
      history, we need to do the same thing now--not excluding ethics, but working hand
      in glove with ethics. This paper suggests that, as in the 1830s, dentistry now
      needs the grassroots attention of its membership. Using recent publications about
      the importance of "connectedness" in dentistry, guidelines are presented that
      provide a framework for approaching the problems faced by dentistry and
      contributing to a more satisfying professional career.
FAU - Rule, James T
AU  - Rule JT
AD  - University of Maryland Dental School, USA. jrule0807@verizon.net
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - J Am Coll Dent
JT  - The Journal of the American College of Dentists
JID - 7503057
SB  - IM
MH  - Dentist-Patient Relations
MH  - Education, Dental/history
MH  - *Ethics, Dental
MH  - History, 19th Century
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Moral Obligations
MH  - Periodicals as Topic/history
MH  - Practice Patterns, Dentists'/*ethics
MH  - Professional Autonomy
MH  - Professional Misconduct/ethics
MH  - *Professional Role
MH  - Schools, Dental/history
MH  - Societies, Dental/history
MH  - Trust
MH  - United States
MH  - Whistleblowing
EDAT- 2010/01/01 00:00
MHDA- 2011/05/11 06:00
CRDT- 2011/04/13 06:00
PHST- 2011/04/13 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2011/05/11 06:00 [medline]
PST - ppublish
SO  - J Am Coll Dent. 2010 Winter;77(4):59-67.


PMID- 21485335
OWN - NLM
STAT- MEDLINE
DCOM- 20110510
LR  - 20110412
IS  - 0002-7979 (Print)
IS  - 0002-7979 (Linking)
VI  - 77
IP  - 4
DP  - 2010 Winter
TI  - Ethics and leadership: pick any two.
PG  - 4-7
FAU - Winkler, Thomas F 3rd
AU  - Winkler TF 3rd
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Coll Dent
JT  - The Journal of the American College of Dentists
JID - 7503057
SB  - IM
MH  - *Ethics, Dental
MH  - Humans
MH  - *Leadership
MH  - *Societies, Dental
MH  - United States
EDAT- 2010/01/01 00:00
MHDA- 2011/05/11 06:00
CRDT- 2011/04/13 06:00
PHST- 2011/04/13 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2011/05/11 06:00 [medline]
PST - ppublish
SO  - J Am Coll Dent. 2010 Winter;77(4):4-7.


PMID- 21483592
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1819-6357 (Electronic)
IS  - 1819-6357 (Linking)
VI  - 5
DP  - 2010 Feb 8
TI  - Association of ABO blood groups with diabetes mellitus.
LID - 10.3402/ljm.v5i0.4847 [doi]
AB  - OBJECTIVE: So far no studies have been performed in Malaysia to look at
      association of diabetes mellitus (DM) with blood groups. We studied the
      association of ABO blood groups with DM type 2. PATIENTS AND METHODOLOGY: It was 
      a case control study conducted at Kepala Batas Hospital Batas, Penang, Malaysia
      in the year 2009, involving 70 patients with DM type 2 and 140 healthy controls. 
      Ethical approval was obtained from Universiti Sains Malaysia. Blood samples were 
      collected from the patients after consent. Samples were tested for ABO blood
      groups using ID-Card gel method. RESULTS: Chi-square test results showed that
      there was an association between the ABO blood groups and DM type 2. It was found
      that A and O blood groups were negatively associated with DM type 2 (P<0.05) with
      higher percentage of A and O groups individuals were non-diabetic. No significant
      association was noted between DM type 2 and blood groups B (P=0.423) and AB
      (P=0.095). It was also noted that B blood group was distributed with highest
      percentage among patients with DM type 2 (53.71%) compared to controls (22.52%), 
      but no statistical significance achieved. CONCLUSION: The results obtained
      suggest that there was a negative association between ABO blood groups A and O
      with DM type 2, with A and O group having less chances of diabetes. Large studies
      in other ethnic groups are needed to confirm these results.
FAU - Kamil, Muhammad
AU  - Kamil M
AD  - Advanced Medical and Dental Institute, Universiti Sains Malaysia, Penang,
      Malaysia.
FAU - Al-Jamal, Hamid Ali Nagi
AU  - Al-Jamal HA
FAU - Yusoff, Narazah Mohd
AU  - Yusoff NM
LA  - eng
PT  - Journal Article
DEP - 20100208
PL  - United States
TA  - Libyan J Med
JT  - The Libyan journal of medicine
JID - 101299403
PMC - PMC3071167
OTO - NOTNLM
OT  - blood group A
OT  - blood group O
OT  - diabetes mellitus
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2011/04/13 06:00
PHST- 2009/09/22 00:00 [received]
PHST- 2010/01/10 00:00 [accepted]
PHST- 2011/04/13 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - 10.3402/ljm.v5i0.4847 [doi]
PST - epublish
SO  - Libyan J Med. 2010 Feb 8;5. doi: 10.3402/ljm.v5i0.4847.


PMID- 21483550
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1819-6357 (Electronic)
IS  - 1819-6357 (Linking)
VI  - 5
DP  - 2010 Jan 7
TI  - 'Take me home and allow me to die peacefully' - an ethical dilemma of grave
      concern.
LID - 10.4176/091014 [doi]
FAU - Sheriff, Dhastagir Sultan
AU  - Sheriff DS
AD  - Department of Biochemistry, Al Arab Medical University, Benghazi, Libya.
LA  - eng
PT  - Journal Article
DEP - 20100107
PL  - United States
TA  - Libyan J Med
JT  - The Libyan journal of medicine
JID - 101299403
PMC - PMC3066755
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2011/04/13 06:00
PHST- 2011/04/13 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - 10.4176/091014 [doi]
PST - epublish
SO  - Libyan J Med. 2010 Jan 7;5. doi: 10.4176/091014.


PMID- 21465842
OWN - NLM
STAT- MEDLINE
DCOM- 20110526
LR  - 20191112
IS  - 0823-2105 (Print)
IS  - 0823-2105 (Linking)
VI  - 27
IP  - 2
DP  - 2010
TI  - Military medicine and the ethics of war: British colonial warfare during the
      Seven Years War (1756-63).
PG  - 273-98
AB  - This article examines 18th-century European warfare, tracing the first formal
      codifications of conventions of war, frequently introduced by military physicians
      and initially regarding the treatment of the sick and wounded. It outlines to
      what extent these conventions were followed in practice, particularly in the
      challenging environment of American irregular warfare, with a focus on the most
      well-known incident of "biological warfare" in the period: the deliberate spread 
      of smallpox by British officers among Amerindians in 1763. More broadly, it
      demonstrates that the history of military medicine provides a fruitful method
      with which to uncover assumptions about the ethics of war.
FAU - Charters, Erica
AU  - Charters E
AD  - Wolfson College, University of Oxford.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - Canada
TA  - Can Bull Med Hist
JT  - Canadian bulletin of medical history = Bulletin canadien d'histoire de la
      medecine
JID - 101130981
MH  - Biological Warfare/ethics/*history
MH  - Colonialism/*history
MH  - History, 18th Century
MH  - Humans
MH  - Indians, North American/history
MH  - Military Medicine/ethics/*history
MH  - Smallpox/*history/transmission
MH  - United Kingdom
MH  - United States
MH  - *Warfare
EDAT- 2010/01/01 00:00
MHDA- 2011/05/27 06:00
CRDT- 2011/04/07 06:00
PHST- 2011/04/07 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2011/05/27 06:00 [medline]
AID - 10.3138/cbmh.27.2.273 [doi]
PST - ppublish
SO  - Can Bull Med Hist. 2010;27(2):273-98. doi: 10.3138/cbmh.27.2.273.


PMID- 21461529
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140610
LR  - 20191112
IS  - 1678-4758 (Electronic)
IS  - 0104-5970 (Linking)
VI  - 17
IP  - 3
DP  - 2010
TI  - [Pain beyond the confines of man: a preliminary introduction to the debate
      between Frances Power Cobbe and the Darwinists with respect to vivisection in
      Victorian England (1863-1904)].
PG  - 577-605
LID - S0104-59702010000300002 [pii]
AB  - This article introduces a person who is little known and studied in the Brazilian
      and South-American academic communities. Frances Power Cobbe was a British woman 
      in the Victorial period engaged in various social causes, among them the
      abolition of vivisection. In her later years, Cobbe criticized any use of live
      animals in laboratory experiments, with or without the use of anesthetics. Our
      initial focus is on the relationship between Cobbe and Charles Darwin and the
      conflict they both were involved in regarding the ethical legitimacy of using
      live animals in physiological experiments for the good (or not) of knowledge and 
      mankind.
FAU - Carvalho, Andre Luis de Lima
AU  - Carvalho AL
AD  - Instituto Oswaldo Cruz, Fiocruz.
FAU - Waizbort, Ricardo
AU  - Waizbort R
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - A dor alem dos confins do homem: aproximacoes preliminares ao debate entre
      Frances Power Cobbe e os darwinistas a respeito da vivisseccao na Inglaterra
      vitoriana (1863-1904).
PL  - Brazil
TA  - Hist Cienc Saude Manguinhos
JT  - Historia, ciencias, saude--Manguinhos
JID - 9513999
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2011/04/05 06:00
PHST- 2009/06/01 00:00 [received]
PHST- 2009/12/01 00:00 [accepted]
PHST- 2011/04/05 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - S0104-59702010000300002 [pii]
AID - 10.1590/s0104-59702010000300002 [doi]
PST - ppublish
SO  - Hist Cienc Saude Manguinhos. 2010;17(3):577-605. doi:
      10.1590/s0104-59702010000300002.


PMID- 21415878
OWN - NLM
STAT- MEDLINE
DCOM- 20110407
LR  - 20191112
IS  - 0264-8725 (Print)
IS  - 0264-8725 (Linking)
VI  - 26
DP  - 2010
TI  - Three-dimensional cell cultures in toxicology.
PG  - 117-38
AB  - Toxicity testing with animals is expensive, ethically controversial, and not
      always predictive of the human response. Cell-based assays are regarded as an
      alternative. However, conventional two-dimensional cell cultures do not reproduce
      the tissue architecture in vivo, and do not forecast organ-specific toxicity. On 
      the other hand, three-dimensional cultures emulate the biochemistry and mechanics
      of the microenvironment in tissues more closely. Therefore, they address the
      limitations of both animals and two-dimensional cultures, and provide more
      accurate data on the effects of short- and long-term exposure to toxicants. We
      provide an up-to-date overview on the use of three-dimensional cell cultures in
      toxicology. We anticipate that three-dimensional cultures will become invaluable 
      to accomplish the 3R agenda (refinement, reduction, and replacement) for
      animal-based toxicity testing and will play a major role for the Registration,
      Evaluation and Authorisation of Chemicals in the European Union (REACH
      legislation).
FAU - Pampaloni, Francesco
AU  - Pampaloni F
AD  - Cell Biology and Biophysics Unit, European Molecular Biology Laboratory,
      Heidelberg, Germany. francesco.pampaloni@embl.de
FAU - Stelzer, Ernst
AU  - Stelzer E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Biotechnol Genet Eng Rev
JT  - Biotechnology & genetic engineering reviews
JID - 8510274
RN  - 0 (Hazardous Substances)
SB  - IM
MH  - Animal Testing Alternatives/*methods
MH  - Animals
MH  - Cell Culture Techniques
MH  - European Union
MH  - Hazardous Substances/*toxicity
MH  - Humans
MH  - Models, Biological
MH  - Spheroids, Cellular/drug effects
MH  - Toxicity Tests/*methods
EDAT- 2010/01/01 00:00
MHDA- 2011/04/08 06:00
CRDT- 2011/03/19 06:00
PHST- 2011/03/19 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2011/04/08 06:00 [medline]
AID - 10.5661/bger-26-117 [doi]
PST - ppublish
SO  - Biotechnol Genet Eng Rev. 2010;26:117-38. doi: 10.5661/bger-26-117.


PMID- 21404185
OWN - NLM
STAT- MEDLINE
DCOM- 20110926
LR  - 20110315
IS  - 1696-3547 (Electronic)
IS  - 0214-6282 (Linking)
VI  - 54
IP  - 11-12
DP  - 2010
TI  - Improvement of mouse cloning using nuclear transfer-derived embryonic stem cells 
      and/or histone deacetylase inhibitor.
PG  - 1641-8
LID - 10.1387/ijdb.103205sw [doi]
AB  - Nuclear transfer-derived ES (ntES) cell lines can be established from somatic
      cell nuclei with a relatively high success rate. Although ntES cells have been
      shown to be equivalent to ES cells, there are ethical objections concerning human
      cells, such as the use of fresh oocyte donation from young healthy woman. In
      contrast, the use of induced pluripotent stem (iPS) cells for cloning poses few
      ethical problems and is a relatively easy technique compared with nuclear
      transfer. Therefore, although there are several reports proposing the use of ntES
      cells as a model of regenerative medicine, the use of these cells in preliminary 
      medical research is waning. However, in theory, 5 to 10 donor cells can establish
      one ntES cell line and, once established, these cells will propagate
      indefinitely. These cells can be used to generate cloned animals from ntES cell
      lines using a second round of NT. Even in infertile and "unclonable" strains of
      mice, we can generate offspring from somatic cells by combining cloning with ntES
      technology. Moreover, cloned offspring can be generated potentially even from the
      nuclei of dead bodies or freeze-dried cells via ntES cells, such as from an
      extinct frozen animal. Currently, only the ntES technology is available for this 
      purpose, because all other techniques, including iPS cell derivation, require
      significant numbers of living donor cells. This review describes how to improve
      the efficiency of cloning, the establishment of clone-derived embryonic stem
      cells and further applications.
FAU - Wakayama, Sayaka
AU  - Wakayama S
AD  - Riken Center for Developmental Biology, Kobe, Japan.
FAU - Wakayama, Teruhiko
AU  - Wakayama T
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Spain
TA  - Int J Dev Biol
JT  - The International journal of developmental biology
JID - 8917470
RN  - 0 (Histone Deacetylase Inhibitors)
SB  - IM
MH  - Animals
MH  - Cell Nucleus/drug effects
MH  - Cloning, Organism/*methods
MH  - Embryonic Stem Cells/cytology/*drug effects
MH  - Histone Deacetylase Inhibitors/*pharmacology
MH  - Humans
MH  - Induced Pluripotent Stem Cells/drug effects
MH  - Mice
MH  - *Nuclear Transfer Techniques
EDAT- 2010/01/01 00:00
MHDA- 2011/09/29 06:00
CRDT- 2011/03/16 06:00
PHST- 2011/03/16 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 103205sw [pii]
AID - 10.1387/ijdb.103205sw [doi]
PST - ppublish
SO  - Int J Dev Biol. 2010;54(11-12):1641-8. doi: 10.1387/ijdb.103205sw.


PMID- 21381395
OWN - NLM
STAT- MEDLINE
DCOM- 20110505
LR  - 20110307
IS  - 1343-4292 (Print)
IS  - 1343-4292 (Linking)
IP  - 128
DP  - 2010
TI  - [Perspective of predictive toxicity assessment of in vivo repeated dose toxicity 
      using structural activity relationship].
PG  - 44-9
AB  - Tens of thousands of existing chemicals have been widely used for manufacture,
      agriculture, household and other purposes in worldwide. Only approximately 10% of
      chemicals have been assessed for human health hazard. The health hazard
      assessment of residual large number of chemicals for which little or no
      information of their toxicity is available is urgently needed for public health. 
      However, the conduct of traditional toxicity tests which involves using animals
      for all of these chemicals would be economically impractical and ethically
      unacceptable. (Quantitative) Structure-Activity Relationships [(Q)SARs] are
      expected as method to have the potential to estimate hazards of chemicals from
      their structure, while reducing time, cost and animal testing currently needed.
      Therefore, our studies have been focused on evaluation of available (Q)SAR
      systems for estimating in vivo repeated toxicity on the liver. The results from
      our preliminary analysis showed the distribution for LogP of the chemicals which 
      have potential to induce liver toxicity was bell-shape and indicating the
      possibility to estimate liver toxicity of chemicals from their physicochemical
      property. We have developed (Q)SAR models to in vivo liver toxicity using three
      commercially available systems (DEREK, ADMEWorks and MultiCASE) as well as
      combinatorial use of publically available chemoinformatic tools (CDK, MOSS and
      WEKA). Distinct data-sets of the 28-day repeated dose toxicity test of new and
      existing chemicals evaluated in Japan were used for model development and
      performance test. The results that concordances of commercial systems and public 
      tools were almost same which below 70% may suggest currently attainable knowledge
      of in silico estimation of complex biological process, though it possible to
      obtain complementary and enhanced performance by combining predictions from
      different programs. In future, the combinatorial application of in silico and in 
      vitro tests might provide more accurate information which support regulatory
      decisions. At the same time, an appropriate strategy to use (Q)SAR for of the
      efficiency and accuracy in chemical management is necessary.
FAU - Ono, Atsushi
AU  - Ono A
AD  - atsushi@nihs.go.jp
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku
JT  - Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National
      Institute of Health Sciences
JID - 9807834
RN  - 0 (Hazardous Substances)
SB  - IM
MH  - Forecasting
MH  - *Hazardous Substances
MH  - *Quantitative Structure-Activity Relationship
MH  - Risk Assessment
MH  - *Toxicity Tests
EDAT- 2010/01/01 00:00
MHDA- 2011/05/06 06:00
CRDT- 2011/03/09 06:00
PHST- 2011/03/09 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2011/05/06 06:00 [medline]
PST - ppublish
SO  - Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku. 2010;(128):44-9.


PMID- 21359115
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 1949-8241 (Print)
VI  - 12
DP  - 2010 Jan 1
TI  - THE CASE FOR AN ETHICS RESEARCH CONSORTIUM FOR EMERGING TECHNOLOGIES: PUBLIC
      PERCEPTION OF STEM CELL RESEARCH AND DEVELOPMENT.
PG  - 21-28
AB  - Emerging technologies have gained notoriety as a catalyst of socioeconomic
      progress, but have also inspired a revolution in ethics. Here, we provide an
      overview of ethics in stem cell-based therapies and offer a compelling argument
      for a need to establish an Ethics Research Consortium that will be tasked to
      assemble an interdisciplinary panel of experts who will apply ethical principles 
      to analyze the social merit relative to the economic incentives of this emerging 
      technology. Milestone studies on cell therapy in Parkinson's disease and stroke
      over the last two decades were the focus of this commentary. The major criterion 
      for study selection was based on public opinion, scientific discussion, and
      government reactions generated by these pioneering studies. Original data from
      the selected studies are presented. Interpretation and discussion of data
      captured the prevailing views of the public and scientific community, as well as 
      the government regulatory and oversight decisions (i.e., ban on embryonic stem
      cell research funding). Lessons learned from two decades of cell-based therapies 
      indicate that poor management of the public discourse of ethics concerning
      emerging technologies might have contributed to misperceptions within both the
      public and the research community that have hindered the progress of scientific
      innovation and even delayed the clinical application of potentially life-saving
      treatments to critically ill patients. We propose the creation of a Consortium
      that will evaluate how these novel ethical issues in emerging technologies are
      addressed under current oversight and regulatory structures and where there may
      be gaps and need for revised or new public policy approaches.
FAU - Borlongan, Cesar V
AU  - Borlongan CV
AD  - Office of Research and Innovation and Department of Neurosurgery and Brain
      Repair, University of South Florida College of Medicine, Tampa, FL, USA.
FAU - McWhirter, Camille
AU  - McWhirter C
FAU - Fultz-Carver, Caroline
AU  - Fultz-Carver C
FAU - Fitzgerald, Kevin T
AU  - Fitzgerald KT
FAU - Sanberg, Paul R
AU  - Sanberg PR
LA  - eng
GR  - R01 AG032432/AG/NIA NIH HHS/United States
GR  - R01 AG032432-02/AG/NIA NIH HHS/United States
GR  - R13 NS070364/NS/NINDS NIH HHS/United States
GR  - R13 NS070364-01/NS/NINDS NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Technol Innov
JT  - Technology and innovation
JID - 101545118
PMC - PMC3043602
MID - NIHMS233986
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
CRDT- 2011/09/28 06:00
PHST- 2011/09/28 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
AID - 10.3727/194982410x12741230805263 [doi]
PST - ppublish
SO  - Technol Innov. 2010 Jan 1;12:21-28. doi: 10.3727/194982410x12741230805263.


PMID- 20038649
OWN - NLM
STAT- MEDLINE
DCOM- 20100304
LR  - 20211020
IS  - 1524-8399 (Print)
IS  - 1524-8399 (Linking)
VI  - 11
IP  - 1
DP  - 2010 Jan
TI  - Ethics and community-based participatory research: perspectives from the field.
PG  - 16-20
LID - 10.1177/1524839909352841 [doi]
AB  - Exploring the importance of ethical issues in the conduct of community-based
      participatory research (CBPR) continues to be an important topic for researchers 
      and practitioners. This article uses the Beyond Sabor Project, a CBPR project
      implemented in the Lower Rio Grande Valley, as a case example to discuss ethical 
      issues such as the importance of increasing community involvement in research,
      ensuring that communities benefit from the research, sharing leadership roles,
      and sensitive issues regarding data collection and sharing. Thereafter, this
      article concludes with a brief discussion of six principles that can inform the
      practice of ethical conduct when implementing CBPR studies. This article also
      lists additional reading resources on the importance of ethics in the conduct of 
      CBPR.
FAU - Bastida, Elena M
AU  - Bastida EM
AD  - Research in the School of Public Health at the University of North Texas Health
      Science Center in Fort Worth, Texas 76107-2699, USA. bastida@hsc.unt.edu
FAU - Tseng, Tung-Sung
AU  - Tseng TS
FAU - McKeever, Corliss
AU  - McKeever C
FAU - Jack, Leonard Jr
AU  - Jack L Jr
LA  - eng
GR  - S21 MD000100/MD/NIMHD NIH HHS/United States
GR  - S21 MD000100-09/MD/NIMHD NIH HHS/United States
GR  - 2S21MD000100-09/MD/NIMHD NIH HHS/United States
GR  - 5 R24 MD001779-04/MD/NIMHD NIH HHS/United States
GR  - R24 MD001779/MD/NIMHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Health Promot Pract
JT  - Health promotion practice
JID - 100890609
SB  - IM
MH  - Community-Based Participatory Research/*methods
MH  - Disclosure/ethics
MH  - *Ethics, Research
MH  - *Health Education
MH  - *Health Promotion
MH  - Humans
MH  - Informed Consent/ethics
MH  - Minority Groups
MH  - Prejudice
MH  - Trust
PMC - PMC3012623
MID - NIHMS257166
EDAT- 2009/12/30 06:00
MHDA- 2010/03/05 06:00
CRDT- 2009/12/30 06:00
PHST- 2009/12/30 06:00 [entrez]
PHST- 2009/12/30 06:00 [pubmed]
PHST- 2010/03/05 06:00 [medline]
AID - 11/1/16 [pii]
AID - 10.1177/1524839909352841 [doi]
PST - ppublish
SO  - Health Promot Pract. 2010 Jan;11(1):16-20. doi: 10.1177/1524839909352841.


PMID- 20037903
OWN - NLM
STAT- MEDLINE
DCOM- 20100603
LR  - 20190917
IS  - 1120-6721 (Print)
IS  - 1120-6721 (Linking)
VI  - 20
IP  - 3
DP  - 2010 May-Jun
TI  - Screening for ophthalmic disorders and visual impairment in a Nigerian school for
      the deaf.
PG  - 596-600
AB  - PURPOSE: To detect the presence of ophthalmic abnormalities and visual impairment
      in deaf students. METHODS: A cross-sectional survey of all students in the school
      for the deaf was conducted following ethical clearance from the Ministry of
      Health. Age, sex, and previous eye examination was recorded for each student as
      well as visual acuity, penlight eye examination, intraocular pressure, dilated
      funduscopy, and refraction (when applicable). Data were analyzed with SPSS
      version 11 and statistical significance inferred at p<0.05. RESULTS: The 156
      (100%) students at the school for the deaf with age range 6-25 years, mean +/-
      standard deviation of 15.6+/-3.3 years, and modal age of 14 years were studied. A
      total of 110 (70.5%) had no previous eye examination, 2 (1.3%) students were
      blind, 5 (3.2%) were visually impaired, 4 (2.6%) had unilateral visual
      impairment, and 4 (2.6%) had unilateral blindness. Blindness was caused by Usher 
      syndrome in 1 (50%) and bilateral pigmented macular scar in 1 (50%) patient.
      Uncorrected refractive errors were the leading cause of unilateral visual
      impairment (75%), visual impairment (60%), and unilateral blindness (50%). Ocular
      abnormality was present in 53 (34%) students while uncorrected refractive error
      (18.6%), retina changes (7%), and allergic conjunctivitis (3.8%) were the leading
      disorders. Previous eye examination was more common among primary school students
      (p<0.0001) and students with ocular abnormalities (p=0.046). CONCLUSIONS:
      Institutions for deaf children should be aware of the high prevalence of
      ophthalmic disorders and the importance of vision to development of a deaf child,
      and conduct an initial and periodic eye examination for every intake.
FAU - Onakpoya, Oluwatoyin Helen
AU  - Onakpoya OH
AD  - Obafemi Awolowo University Teaching Hospital, Ile-Ife, Osun State - Nigeria.
      uvtoyin2@yahoo.co.uk
FAU - Omotoye, Olusola J
AU  - Omotoye OJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Eur J Ophthalmol
JT  - European journal of ophthalmology
JID - 9110772
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Cross-Sectional Studies
MH  - Deafness/*epidemiology
MH  - Disabled Children/*education
MH  - Eye Diseases/*diagnosis/epidemiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Nigeria/epidemiology
MH  - *Persons With Hearing Impairments
MH  - Prevalence
MH  - Schools
MH  - Visual Acuity
MH  - *Visually Impaired Persons
MH  - Young Adult
EDAT- 2009/12/29 06:00
MHDA- 2010/06/04 06:00
CRDT- 2009/12/29 06:00
PHST- 2009/12/29 06:00 [entrez]
PHST- 2009/12/29 06:00 [pubmed]
PHST- 2010/06/04 06:00 [medline]
AID - D8EA4DFD-F6D7-4A07-AD22-B8A342DC9B24 [pii]
AID - 10.1177/112067211002000310 [doi]
PST - ppublish
SO  - Eur J Ophthalmol. 2010 May-Jun;20(3):596-600. doi: 10.1177/112067211002000310.


PMID- 20037499
OWN - NLM
STAT- MEDLINE
DCOM- 20100322
LR  - 20091228
IS  - 1643-3750 (Electronic)
IS  - 1234-1010 (Linking)
VI  - 16
IP  - 1
DP  - 2010 Jan
TI  - Federal funding for needle exchange programs.
PG  - PH1-13
AB  - The HIV/AIDS pandemic has affected millions across the globe. The sharing of
      needles, for reasons of economy or social relations, has become the most common
      mode of HIV transmission among injection drug users. Needle exchange programs,
      which provide many services in addition to the exchange of clean needles for
      contaminated needles, have proven effective in reducing HIV rates among injection
      drug users in their communities. Although these programs have proven to be one of
      the most effective strategies in the efforts to reduce HIV rates, there has been 
      a federal ban on the use of federal money for needle exchange programs since
      1989. This ban was introduced by Congress in accordance with the drug war
      ideology, a narrow and elusive plan to completely eradicate drug use in the
      United States. Although there are a significant number of government reports
      supporting needle exchange programs, including support from the CDC, American
      Medical Association, the National Institutes of Health, it appears as If public
      health and the lives of others have become a secondary concern to strong federal 
      policy on eradicating drug use. Lifting the federal ban would save the country
      millions of lives and billions of dollars in healthcare costs. Needle exchange
      programs should be an integral part of HIV prevention strategy, and are ethically
      imperative as well, restoring human dignity to the clients that so often need
      it.<br />
FAU - Clark, Peter A
AU  - Clark PA
AD  - Institute of Catholic Bioethics, Saint Joseph's University, Philadelphia, PA,
      USA. pclark@sju.edu
FAU - Fadus, Matthew
AU  - Fadus M
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and
      clinical research
JID - 9609063
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/*prevention & control
MH  - Financing, Government/*economics
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Needle-Exchange Programs/ethics/history/*legislation & jurisprudence/*statistics 
      & numerical data
MH  - United States
EDAT- 2009/12/29 06:00
MHDA- 2010/03/23 06:00
CRDT- 2009/12/29 06:00
PHST- 2009/12/29 06:00 [entrez]
PHST- 2009/12/29 06:00 [pubmed]
PHST- 2010/03/23 06:00 [medline]
AID - 878301 [pii]
PST - ppublish
SO  - Med Sci Monit. 2010 Jan;16(1):PH1-13.


PMID- 20036924
OWN - NLM
STAT- MEDLINE
DCOM- 20100930
LR  - 20220227
IS  - 1945-0524 (Electronic)
IS  - 1945-0516 (Linking)
VI  - 2
IP  - 1
DP  - 2010 Jan 1
TI  - Animal ethics in SIRS research.
PG  - 5-10
AB  - It is well recognized that animals play a vital role and are indispensable to
      scientific and medical research. Over the years, a number of non-animal
      procedures have been developed. However, despite all the advances in science, as 
      yet, no system has been evolved which can completely replace a living system to
      conduct basic research. There is still a need to test food, drugs, medical
      devices, treatment regimes etc. on some animals before they can be tested and
      used (if found suitable) in human beings. Even the most sophisticated technology 
      models have failed to mimic completely the complex cellular interactions
      occurring in a living system. The search for a complete alternative to animal
      research is still on and in the mean time we can all help play our part by
      conducting animal research in a humane and responsible fashion. This chapter
      discusses the ethical issues in animal research highlighting the need to use
      animals conscientiously.
FAU - Dahiya, Punam
AU  - Dahiya P
AD  - Food and Veterinary Administration, Agri-Food and Veterinary Authority of
      Singapore, 5 Maxwell Road, #02-03 Tower Block, MND Complex, Singapore 069110.
      Punam_dahiya@ava.gov.sg
FAU - Ogden, Bryan E
AU  - Ogden BE
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20100101
PL  - Singapore
TA  - Front Biosci (Schol Ed)
JT  - Frontiers in bioscience (Scholar edition)
JID - 101485241
SB  - IM
MH  - *Animal Care Committees
MH  - Animal Experimentation/*ethics
MH  - Animal Use Alternatives/*methods/trends
MH  - *Animal Welfare
MH  - Animals
MH  - *Ethics, Research
MH  - Singapore
MH  - Social Control, Formal
MH  - *Systemic Inflammatory Response Syndrome
MH  - United States
RF  - 7
EDAT- 2009/12/29 06:00
MHDA- 2010/10/01 06:00
CRDT- 2009/12/29 06:00
PHST- 2009/12/29 06:00 [entrez]
PHST- 2009/12/29 06:00 [pubmed]
PHST- 2010/10/01 06:00 [medline]
AID - 41 [pii]
AID - 10.2741/s41 [doi]
PST - epublish
SO  - Front Biosci (Schol Ed). 2010 Jan 1;2(1):5-10. doi: 10.2741/s41.


PMID- 20036651
OWN - NLM
STAT- MEDLINE
DCOM- 20100901
LR  - 20121115
IS  - 1872-7786 (Electronic)
IS  - 0009-2797 (Linking)
VI  - 187
IP  - 1-3
DP  - 2010 Sep 6
TI  - Assessment of neuromuscular dysfunction during poisoning by organophosphorus
      compounds.
PG  - 265-9
LID - 10.1016/j.cbi.2009.12.027 [doi]
AB  - Dysfunction of respiratory muscles is a life-threatening complication in
      poisoning by organophosphorus compounds (OPs). It is both of central and
      peripheral origin due to impaired cholinergic signalling upon inhibition of
      acetylcholinesterase (AChE). The dysfunction at neuromuscular synapses is not
      amenable to anticholinergics and remains a therapeutic challenge. Thus, a clear
      understanding of the distinct mechanisms occurring at neuromuscular synapses is
      decisive for the development and improvement of therapeutic strategies,
      particularly with nerve agent poisoning, where clinical studies are prevented by 
      ethical considerations. Using red blood cell AChE, the kinetics of OP induced
      inhibition, aging, and spontaneous and oxime-induced reactivation have been
      elucidated. In a dynamically working in vitro model with real-time determination 
      of membrane-bound AChE, it was shown that the kinetic constants derived from
      erythrocyte AChE are comparable to muscle AChE in a given species. To assess,
      whether kinetic considerations of AChE activity are relevant for the
      neuromuscular function, organotypic spinal cord-skeletal muscle cocultures have
      been established. In this model neostigmine and VX affected neuromuscular
      transmission as anticipated from their known actions on AChE. Also oxime-induced 
      restoration of the neuromuscular transmission was observed. These findings were
      confirmed by functional studies on diaphragm muscles of various species with
      determination of muscle force generation upon phrenic nerve or indirect
      electrical field stimulation techniques. Investigations with human intercostal
      muscles are in progress to assess the conditions in human tissue. The results
      obtained with paraoxon favourably correlate with data from clinical findings of
      parathion-poisoned patients where the correlation of neuromuscular transmission
      with the activity of erythrocyte AChE could be established. In conclusion, a
      variety of methods are available to follow the microscopic reactions occurring at
      the synaptic level. Due to the lack of clinical data with different OPs, e.g.
      nerve agents, well designed animal experiments, reflecting the human situation as
      close as possible, are indispensable for the development of new drugs against the
      deleterious OP effects.
CI  - Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
FAU - Thiermann, Horst
AU  - Thiermann H
AD  - Bundeswehr Institute of Pharmacology and Toxicology, Neuheerbergstr. 11, 80937
      Munich, Germany. HorstThiermann@bundeswehr.org
FAU - Seeger, Thomas
AU  - Seeger T
FAU - Gonder, Sascha
AU  - Gonder S
FAU - Herkert, Nadja
AU  - Herkert N
FAU - Antkowiak, Bernd
AU  - Antkowiak B
FAU - Zilker, Thomas
AU  - Zilker T
FAU - Eyer, Florian
AU  - Eyer F
FAU - Worek, Franz
AU  - Worek F
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20091229
PL  - Ireland
TA  - Chem Biol Interact
JT  - Chemico-biological interactions
JID - 0227276
RN  - 0 (Chemical Warfare Agents)
RN  - 0 (Organophosphorus Compounds)
RN  - 0 (Oximes)
SB  - IM
MH  - Animals
MH  - Chemical Warfare Agents/*poisoning
MH  - Humans
MH  - Kinetics
MH  - Muscles/drug effects/pathology/physiopathology
MH  - Neuromuscular Junction/*drug effects/*physiopathology
MH  - *Organophosphate Poisoning
MH  - Organophosphorus Compounds/antagonists & inhibitors
MH  - Oximes/pharmacology
RF  - 32
EDAT- 2009/12/29 06:00
MHDA- 2010/09/02 06:00
CRDT- 2009/12/29 06:00
PHST- 2009/11/06 00:00 [received]
PHST- 2009/12/17 00:00 [revised]
PHST- 2009/12/21 00:00 [accepted]
PHST- 2009/12/29 06:00 [entrez]
PHST- 2009/12/29 06:00 [pubmed]
PHST- 2010/09/02 06:00 [medline]
AID - S0009-2797(09)00572-9 [pii]
AID - 10.1016/j.cbi.2009.12.027 [doi]
PST - ppublish
SO  - Chem Biol Interact. 2010 Sep 6;187(1-3):265-9. doi: 10.1016/j.cbi.2009.12.027.
      Epub 2009 Dec 29.


PMID- 20036435
OWN - NLM
STAT- MEDLINE
DCOM- 20100706
LR  - 20100407
IS  - 1872-6054 (Electronic)
IS  - 0168-8510 (Linking)
VI  - 95
IP  - 2-3
DP  - 2010 May
TI  - The US Orphan Drug Act: rare disease research stimulator or commercial
      opportunity?
PG  - 216-28
LID - 10.1016/j.healthpol.2009.12.001 [doi]
AB  - OBJECTIVES: This study investigates issues associated with the United States
      Orphan Drug Act. METHODS: A comprehensive orphan drug database was compiled from 
      FDA data and corporate annual reports of major pharmaceutical companies. Analysis
      allowed the generation of a descriptive orphan drug portrait as well as
      documentation of orphan drugs along their lifecycle. RESULTS: Currently, 2002
      products have obtained orphan drug designation with 352 drugs obtaining FDA
      approval. Approximately 33% of orphan drugs are oncology products. On average,
      products obtain 1.7 orphan designations with approximately 70% obtaining a single
      designation. At least 9% of orphan drugs have reached blockbuster status with
      two-thirds having two or more designations. An additional 25 orphan drugs had
      sales exceeding US$ 100 million in 2008 alone. Since 1983, at least 14 previously
      discontinued products have been recycled as orphan drugs. CONCLUSIONS: The United
      States Orphan Drug Act has created issues which, in some cases, have led to
      commercial and ethical abuses. Orphan Drug Act reform is necessary but current
      incentives, including 7 year market exclusivity, should be maintained in order to
      favour patients as well as economic prosperity. Suggested reforms include price
      regulation, subsidy paybacks for profitable drugs and the establishment of an
      International Orphan Drug Office.
CI  - Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
FAU - Wellman-Labadie, Olivier
AU  - Wellman-Labadie O
AD  - Division of Dermatology, Department of Medicine, University of British Columbia, 
      835 West 10th Ave, Vancouver, BC, Canada. wello85@hotmail.com
FAU - Zhou, Youwen
AU  - Zhou Y
LA  - eng
PT  - Journal Article
DEP - 20091229
PL  - Ireland
TA  - Health Policy
JT  - Health policy (Amsterdam, Netherlands)
JID - 8409431
MH  - Annual Reports as Topic
MH  - Commerce/economics
MH  - Databases, Factual
MH  - Drug Approval/*organization & administration
MH  - Drug Industry/ethics/*organization & administration
MH  - Health Care Reform
MH  - Health Services Needs and Demand
MH  - Humans
MH  - Marketing of Health Services
MH  - Motivation
MH  - Organizations/organization & administration
MH  - *Orphan Drug Production/economics/ethics/legislation & jurisprudence
MH  - Rare Diseases/*drug therapy
MH  - Research Support as Topic/ethics/*organization & administration
MH  - United States
MH  - United States Food and Drug Administration
MH  - Vulnerable Populations
EDAT- 2009/12/29 06:00
MHDA- 2010/07/07 06:00
CRDT- 2009/12/29 06:00
PHST- 2009/09/09 00:00 [received]
PHST- 2009/12/01 00:00 [revised]
PHST- 2009/12/02 00:00 [accepted]
PHST- 2009/12/29 06:00 [entrez]
PHST- 2009/12/29 06:00 [pubmed]
PHST- 2010/07/07 06:00 [medline]
AID - S0168-8510(09)00325-X [pii]
AID - 10.1016/j.healthpol.2009.12.001 [doi]
PST - ppublish
SO  - Health Policy. 2010 May;95(2-3):216-28. doi: 10.1016/j.healthpol.2009.12.001.
      Epub 2009 Dec 29.


PMID- 20035357
OWN - NLM
STAT- MEDLINE
DCOM- 20100715
LR  - 20220409
IS  - 1432-0932 (Electronic)
IS  - 0940-6719 (Linking)
VI  - 19
IP  - 2
DP  - 2010 Feb
TI  - Clinical results and development of heterotopic ossification in total cervical
      disc replacement during a 4-year follow-up.
PG  - 307-15
LID - 10.1007/s00586-009-1259-3 [doi]
AB  - Cervical total disc replacement (CTDR) aims to decrease the incidence of adjacent
      segment disease through motion preservation in the operated disc space. Ongoing
      data collection and increasing number of studies describing heterotopic
      ossification (HO) resulting in decreased mobility of implants, forced us to
      carefully evaluate our long-term clinical and morphological results of patients
      with CTDR. We present the first 54 consecutive patients treated with 65 ProdiscC 
      prostheses during a 12-month period (2/2004-3/2005). All patients signed an
      informed consent and were included in prospective long-term study approved by
      hospital ethical committee. The 1- and 2-year follow-up analysis were available
      for all patients included and 4-year results for 50 patients (60 implants).
      Clinical (neck disability index-NDI, visual analog scale-VAS) and radiological
      follow-up was conducted at 1-, 2- and 4-years after the procedure. The
      Mehren/Suchomel modification of McAfee scale was used to classify the appearance 
      of HO. Mean preoperative NDI was 34.5%, VAS for neck pain intensity 4.6 and VAS
      for arm pain intensity 5.0. At 1-, 2- and 4-year follow-up, the mean NDI was
      30.7, 27.2, and 30.4, mean VAS for neck pain intensity 2.5, 2.1 and 2.9 and mean 
      VAS for arm pain intensity pain 2.2, 1.9 and 2.3, respectively. Significant HO
      (grade III) was present in 45% of implants and segmental ankylosis (grade IV) in 
      another 18% 4 years after intervention. This finding had no clinical consequences
      and 92% of patients would undergo the same surgery again. Our clinical results
      (NDI, VAS) are comparable with fusion techniques. Although, advanced non-fusion
      technology is used, a significant frequency of HO formation and spontaneous
      fusion in cervical disc replacement surgery must be anticipated during long-term 
      follow-up.
FAU - Suchomel, Petr
AU  - Suchomel P
AD  - Department of Neurosurgery, Regional Hospital Liberec, Liberec, Czech Republic.
FAU - Jurak, Lubomir
AU  - Jurak L
FAU - Benes, Vladimir 3rd
AU  - Benes V 3rd
FAU - Brabec, Radim
AU  - Brabec R
FAU - Bradac, Ondrej
AU  - Bradac O
FAU - Elgawhary, Shamel
AU  - Elgawhary S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091225
PL  - Germany
TA  - Eur Spine J
JT  - European spine journal : official publication of the European Spine Society, the 
      European Spinal Deformity Society, and the European Section of the Cervical Spine
      Research Society
JID - 9301980
SB  - IM
MH  - Adult
MH  - Ankylosis/etiology/pathology/physiopathology
MH  - Cervical Vertebrae/pathology/*surgery
MH  - Disability Evaluation
MH  - Diskectomy/*adverse effects
MH  - Female
MH  - Follow-Up Studies
MH  - Head Movements/physiology
MH  - Humans
MH  - Internal Fixators/adverse effects
MH  - Intervertebral Disc Displacement/*complications/pathology/*surgery
MH  - Male
MH  - Middle Aged
MH  - Neck Pain/etiology/pathology/physiopathology
MH  - Ossification, Heterotopic/*etiology/pathology/physiopathology
MH  - Pain Measurement
MH  - Postoperative Complications/*etiology/pathology/physiopathology
MH  - Range of Motion, Articular/physiology
MH  - Recurrence
MH  - Spinal Fusion/adverse effects
MH  - Stress, Mechanical
MH  - Time
MH  - Time Factors
MH  - Weight-Bearing/physiology
PMC - PMC2899807
EDAT- 2009/12/26 06:00
MHDA- 2010/07/16 06:00
CRDT- 2009/12/26 06:00
PHST- 2009/11/30 00:00 [received]
PHST- 2009/12/13 00:00 [accepted]
PHST- 2009/12/26 06:00 [entrez]
PHST- 2009/12/26 06:00 [pubmed]
PHST- 2010/07/16 06:00 [medline]
AID - 10.1007/s00586-009-1259-3 [doi]
PST - ppublish
SO  - Eur Spine J. 2010 Feb;19(2):307-15. doi: 10.1007/s00586-009-1259-3. Epub 2009 Dec
      25.


PMID- 20035350
OWN - NLM
STAT- MEDLINE
DCOM- 20101014
LR  - 20220311
IS  - 1432-2218 (Electronic)
IS  - 0930-2794 (Linking)
VI  - 24
IP  - 7
DP  - 2010 Jul
TI  - Video. Endoscopic minimally invasive thyroidectomy: first clinical experience.
PG  - 1757-8
LID - 10.1007/s00464-009-0820-9 [doi]
AB  - BACKGROUND: Since Theodor Kocher reduced the mortality rate of thyroidectomy from
      the 40% reported by Billroth to 0.2% in 1895, a collar incision with open removal
      of the thyroid gland is the standard procedure. In the past decade, efforts were 
      made to reduce incision size and surgical access trauma by the use of endoscopic 
      techniques. A first attempt was replacement of the central "Kocher incision" with
      lateral neck incisions and endoscopic removal of a thyroid lobe by Huscher on 8
      July 1996. This lateral access was limited to removing only one lobe of the
      gland. The most common technique to date is the one developed by Miccoli et al.
      These authors reduced the incision to a size of 20 to 25 mm and operated on the
      thyroid by the use of video-endoscopic assistance (MIVAT). Several groups have
      described an access outside the frontal neck region via a chest, axillary, or
      combined axillary bilateral breast approach. These accesses only moved the entry 
      point from the frontal neck region to other regions, where they are still
      visible. The aforementioned minimally invasive approach and the conventional open
      approach do not respect anatomically given surgical planes and may therefore
      result in patient complaints, especially swallowing disorders after the scaring
      of the subcutaneous tissues. These extracervical approaches are associated with
      an extensive dissection in the access area and thus are maximally invasive.
      Therefore, we developed an exclusively endoscopic approach for thyroid resection 
      with standard instruments used for minimally invasive surgery (diameter, 3.5 mm).
      This endoscopic minimally invasive thyroidectomy (eMIT) technique was evaluated
      carefully by anatomic and cadaver dissections as well as ultrasound studies for
      technical realization and needs for instrument design. To verify the safety and
      feasibility of the method, an animal trial was conducted in August 2008. Surgery 
      was performed securely on five pigs, with very low blood loss. The postoperative 
      behavior with special regard for feeding and pain reaction was normal until
      dissection. Especially, no local infection in the oral cavity or cervical spaces 
      was noted. METHODS: All the trials of eMIT showed good results, so we went on to 
      its first clinical application in the spring of 2009. A 53-year-old man had
      experienced dysphagia for more than a year. During routine diagnosis, the thyroid
      hormones T3, T4, and TSH were controlled and within normal levels. Thyroid
      scintigraphy, B-mode ultrasound examination, and laryngoscopy were performed
      preoperatively. An euthyroid nodular chance of the right hemithyroid with a
      beginning focal autonomy was diagnosed. After the patient's informed consent was 
      received, surgery was performed on 18 March 2009 in an interdisciplinary
      collaboration between a general surgeon and a head and neck surgeon. The first
      incision was made in the midline sublingually. A 5-mm trocar was directed through
      the floor of the mouth muscles into the subplatysmal layer and positioned at the 
      level of the cricoid. Carbon dioxide then was insufflated at 6 mmHg to build a
      tent above the thyroid gland. Next, a second trocar for insertion of the surgical
      instruments was placed over a vestibular incision into the same subplatysmal
      layer. This allowed the surgical field to be visualized fully and dissected with 
      3.7-mm standard minimally-invasive instruments. A third trocar for surgical
      instruments then was placed through an incision on the left side of the vestibule
      of the mouth. After a midline incision of the linea alba, the fibrous capsule of 
      the thyroid gland could been seen. The isthmus then was prepared in total. Next, 
      the strap muscles above the right hemithyroid were prepared, showing the right
      upper pole. With the Harmonic scalpel, the isthmus was divided on the left side. 
      The gland was loosened from the trachea and the adjacent lamella. The vessels of 
      the upper pole were divided by Ultracision (Ethicon-Endosurgery, Cincinnate/Ohio,
      USA). Under the adjacent lamella, the recurrent nerve was visualized and
      stimulated. Neuro-monitoring showed an intact function of the nerve. Finally, the
      lower pole was detached, allowing the thyroid to be freely movable. Recovery of
      the tumor was performed through the median trocar incision after the optic device
      was moved through a lateral trocar. The tumor volume was 5.5 ml. The operation
      site was checked for bleedings and lavaged with sodium chloride. After removal of
      all the trocars, the wounds were sutured with self-resorbable sutures. Plaster
      tape was applied for 24 h. No direct postoperative complications occurred.
      Postoperative histology showed a colloidal struma. RESULTS: The floor of the
      mouth healed well, with no local infections at the incision sites or in the
      cervical spaces. Vocal cord function, evaluated by direct video-laryngoscopy, was
      normal. The patient had minimal swelling of the neck and a small hematoma, which 
      resolved within 2 weeks. He had neither swallowing disorders nor oral pain. His
      preoperative dysphagia was gone, and he left the clinic 2 days after surgery
      without any complaints. CONCLUSION: With the development of an exclusively
      endoscopic approach for thyroid resection (eMIT) and its first clinical
      application, we could show the safety and feasibility of another natural orifice 
      surgery procedure. One major concern before surgery was possible infection of the
      cervical spaces by introduction of oral flora to these regions. Investigating
      this infection risk, Hong and Yang evaluated the surgical results associated with
      the intraoral approach for submandibulectomy in a series of 77 cases of chronic
      sialadenitis and benign mixed tumors. The infection rate was 2.6% (2 patients)
      compared with 7.3% in a control group of 251 patients who underwent a
      transcervical procedure. Therefore, we estimated the infection risk to be lower
      than with conventional transcervical approaches. The clear advantages of this
      technique are its minimally invasive character, its reduction of surgical trauma,
      its direct access to surgical planes and spaces, its avoidance of swallowing
      disorders and postoperative dysphagia, and finally, its avoidance of any skin
      scars. Further trials are already being conducted.
FAU - Wilhelm, Thomas
AU  - Wilhelm T
AD  - Department of Otolaryngology, Head, Neck, and Facial Plastic Surgery, Helios
      Kliniken Leipziger Land, Rudolf-Virchow-Strasse 2, D-04552, Borna, Germany.
      thomas.wilhelm@helios-kliniken.de
FAU - Metzig, Andreas
AU  - Metzig A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Video-Audio Media
DEP - 20091225
PL  - Germany
TA  - Surg Endosc
JT  - Surgical endoscopy
JID - 8806653
SB  - IM
MH  - Dissection
MH  - *Endoscopy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Thyroid Gland/*surgery
MH  - Thyroid Nodule/*surgery
MH  - Thyroidectomy/*methods
MH  - Videotape Recording
EDAT- 2009/12/26 06:00
MHDA- 2010/10/15 06:00
CRDT- 2009/12/26 06:00
PHST- 2009/05/13 00:00 [received]
PHST- 2009/12/02 00:00 [accepted]
PHST- 2009/12/26 06:00 [entrez]
PHST- 2009/12/26 06:00 [pubmed]
PHST- 2010/10/15 06:00 [medline]
AID - 10.1007/s00464-009-0820-9 [doi]
PST - ppublish
SO  - Surg Endosc. 2010 Jul;24(7):1757-8. doi: 10.1007/s00464-009-0820-9. Epub 2009 Dec
      25.


PMID- 20032759
OWN - NLM
STAT- MEDLINE
DCOM- 20100311
LR  - 20151119
IS  - 1539-0683 (Electronic)
IS  - 0361-929X (Linking)
VI  - 35
IP  - 1
DP  - 2010 Jan-Feb
TI  - Perceptions regarding oocyte donation in a group of female college students.
PG  - 40-6
LID - 10.1097/01.NMC.0000366809.52208.60 [doi]
AB  - PURPOSE: To describe the perceptions of young female college students regarding
      oocyte donation (OD). METHODS: Descriptive survey of 330 female undergraduates.
      RESULTS: The subjects were primarily middle class, White, Christian, and lived in
      rural or suburban areas of upstate New York. The majority knew little about OD,
      but felt that the risk, time commitment, medications, and compensation would be
      most important in their decision to participate. Twenty-three percent would
      consider OD; 43% would most likely not consider it. Primary motivational factors 
      for considering OD would be: helping another woman or couple (82%), and
      reimbursement for time and effort (11%). Deterring factors included medication
      and procedural risks (33%), lack of knowledge (30%), invasiveness of the process 
      (21%), ethical reasons (7.5%), and religious reasons (6.5%). CLINICAL
      IMPLICATIONS: Young female college students are routinely targeted for oocyte
      donation. It is essential that nurses who work in university health settings,
      reproductive endocrinology, or other obstetrics/gynecology venues be educated
      about oocyte donation, and be ready to provide nonbiased, comprehensive, and
      current information to college-age women. Education for this group should include
      medication side effects, procedural risks, recipient characteristics, and ethical
      considerations such as disposition of embryos. Nursing educators should also
      consider adding OD as a contemporary topic in nursing school curricula.
FAU - Stevens, Joanne B
AU  - Stevens JB
AD  - The College at Brockport, State University of New York, NY, USA.
      Jstevens@brockport.edu
FAU - Hayes, Cassandra
AU  - Hayes C
LA  - eng
PT  - Journal Article
PL  - United States
TA  - MCN Am J Matern Child Nurs
JT  - MCN. The American journal of maternal child nursing
JID - 7605941
SB  - IM
MH  - Adult
MH  - Altruism
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - New York
MH  - Nurse's Role
MH  - Oocyte Donation/*psychology
MH  - *Social Perception
MH  - Students/*psychology
MH  - Surveys and Questionnaires
MH  - Tissue Donors/*psychology
MH  - Women's Health
MH  - Young Adult
EDAT- 2009/12/25 06:00
MHDA- 2010/03/12 06:00
CRDT- 2009/12/25 06:00
PHST- 2009/12/25 06:00 [entrez]
PHST- 2009/12/25 06:00 [pubmed]
PHST- 2010/03/12 06:00 [medline]
AID - 10.1097/01.NMC.0000366809.52208.60 [doi]
AID - 00005721-201001000-00009 [pii]
PST - ppublish
SO  - MCN Am J Matern Child Nurs. 2010 Jan-Feb;35(1):40-6. doi:
      10.1097/01.NMC.0000366809.52208.60.


PMID- 20032315
OWN - NLM
STAT- MEDLINE
DCOM- 20100204
LR  - 20220310
IS  - 1533-4406 (Electronic)
IS  - 0028-4793 (Linking)
VI  - 362
IP  - 4
DP  - 2010 Jan 28
TI  - Medicine's ethical responsibility for health care reform--the Top Five list.
PG  - 283-5
LID - 10.1056/NEJMp0911423 [doi]
FAU - Brody, Howard
AU  - Brody H
AD  - Institute for the Medical Humanities, University of Texas Medical Branch,
      Galveston, USA.
LA  - eng
PT  - Journal Article
DEP - 20091223
PL  - United States
TA  - N Engl J Med
JT  - The New England journal of medicine
JID - 0255562
SB  - IM
MH  - *Bioethical Issues
MH  - Comparative Effectiveness Research
MH  - *Cost Control/ethics/methods
MH  - Evidence-Based Medicine
MH  - Health Care Costs/legislation & jurisprudence
MH  - Health Care Reform/*ethics/legislation & jurisprudence
MH  - Humans
MH  - Insurance Coverage/economics/ethics
MH  - Insurance, Health/economics/ethics/legislation & jurisprudence
MH  - Medicine
MH  - *Physician's Role
MH  - United States
MH  - Unnecessary Procedures/*economics
EDAT- 2009/12/25 06:00
MHDA- 2010/02/05 06:00
CRDT- 2009/12/25 06:00
PHST- 2009/12/25 06:00 [entrez]
PHST- 2009/12/25 06:00 [pubmed]
PHST- 2010/02/05 06:00 [medline]
AID - NEJMp0911423 [pii]
AID - 10.1056/NEJMp0911423 [doi]
PST - ppublish
SO  - N Engl J Med. 2010 Jan 28;362(4):283-5. doi: 10.1056/NEJMp0911423. Epub 2009 Dec 
      23.


PMID- 20032156
OWN - NLM
STAT- MEDLINE
DCOM- 20100126
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 254
IP  - 1
DP  - 2010 Jan
TI  - Brachial plexus birth injury: US screening for glenohumeral joint instability.
PG  - 253-60
LID - 10.1148/radiol.09090570 [doi]
AB  - PURPOSE: To prospectively evaluate the use and optimal timing of ultrasonographic
      (US) screening for posterior shoulder subluxation in infantswith brachial plexus 
      birth injury (BPBI). MATERIALS AND METHODS: Approval of the ethics committee and 
      informed consent of guardians was obtained. This population-based prospective
      study included neonates with BPBI who were born in Helsinki from January 1, 2003 
      through December 31, 2006, and in whom BPBI was verified with sequential clinical
      examinations. US was performed at 1, 3, 6, and 12 months. Size (width and height)
      of the humeral head and its ossification center and congruency of the shoulder
      (alpha angle) were measured. Frequency of BPBI and permanent changes were
      evaluated. This study also included patients who were referred from the tertiary 
      catchment area. For statistical analysis, 95% confidence intervals were
      calculated, and analysis of variance was performed. RESULTS: BPBI was seen in 132
      of 41980 neonates (3.1 per 1000). In 27 cases (0.64 per 1000), BPBI did not heal 
      during the 1st year of life and was considered permanent. The humeral head and
      its ossification center were smaller on the affected side in permanent BPBI. Nine
      patients with permanent palsy had posterior subluxation of the humeral head
      depicted with US (alpha angle, >30 degrees ). In five patients, posterior
      subluxation [corrected] was detected at 3 months. Nineteen of 21 patients with
      BPBI from the tertiary catchment area had permanent palsy. Ten of 19 patients
      developed posterior subluxation of the shoulder, which was verified with US.
      Altogether, three of these cases were not detected by surgeons. Posterior
      subluxation of the humeral head developed during the 1st year of life in
      one-third of patients with permanent BPBI. In more than one-half (55% [five of
      nine]) of the patients, posterior subluxation [corrected] was detected with US at
      3 months, and in 89% (eight of nine), it was detected at 6 months. CONCLUSION: US
      is a fast and useful tool for diagnosis of posterior subluxation of the humeral
      head, and examination of the glenohumeral joint should be performed at 3 and 6
      months of age in infants with BPBI if symptoms persist.
FAU - Poyhia, Tiina H
AU  - Poyhia TH
AD  - Department of Radiology, Helsinki Medical Imaging Center, Helsinki University
      Central Hospital, POB 281, Helsinki, FIN-00029 HUS, Finland. tiina.poyhia@hus.fi
FAU - Lamminen, Antti E
AU  - Lamminen AE
FAU - Peltonen, Jari I
AU  - Peltonen JI
FAU - Kirjavainen, Mikko O
AU  - Kirjavainen MO
FAU - Willamo, Patrick J
AU  - Willamo PJ
FAU - Nietosvaara, Yrjana
AU  - Nietosvaara Y
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
EIN - Radiology. 2010 Apr;255(1):308
MH  - Analysis of Variance
MH  - Brachial Plexus Neuropathies/*complications
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Joint Instability/*diagnostic imaging/physiopathology
MH  - Male
MH  - Prospective Studies
MH  - Shoulder Dislocation/*diagnostic imaging/physiopathology
MH  - Shoulder Joint/*diagnostic imaging/physiopathology
MH  - Ultrasonography
EDAT- 2009/12/25 06:00
MHDA- 2010/01/27 06:00
CRDT- 2009/12/25 06:00
PHST- 2009/12/25 06:00 [entrez]
PHST- 2009/12/25 06:00 [pubmed]
PHST- 2010/01/27 06:00 [medline]
AID - 254/1/253 [pii]
AID - 10.1148/radiol.09090570 [doi]
PST - ppublish
SO  - Radiology. 2010 Jan;254(1):253-60. doi: 10.1148/radiol.09090570.


PMID- 20032155
OWN - NLM
STAT- MEDLINE
DCOM- 20100126
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 254
IP  - 1
DP  - 2010 Jan
TI  - Assessment of metabolic response to radioimmunotherapy with 90Y-ibritumomab
      tiuxetan in patients with relapsed or refractory B-cell non-Hodgkin lymphoma.
PG  - 245-52
LID - 10.1148/radiol.09090603 [doi]
AB  - PURPOSE: To prospectively compare the assessment of metabolic response to yttrium
      90 ((90)Y)-ibritumomab tiuxetan radioimmunotherapy (RIT) by using fluorine 18
      ((18)F) fluorodeoxyglucose (FDG) combined positron emission tomographic-computed 
      tomographic (PET/CT) imaging at 2 and 6 months to determine the most appropriate 
      time to detect therapeutic response in refractory non-Hodgkin lymphoma (NHL)
      patients treated with RIT. MATERIALS AND METHODS: The ethical committee of the
      university approved the protocol and all patients signed informed consent.
      Twenty-three consecutive patients (10 women, 13 men; mean age, 51.8 years +/-7.3 
      [standard deviation]) treated by using RIT for relapsed or refractory follicular 
      NHL were enrolled. For all patients, (18)F FDG PET/CT scanning was performed at
      baseline and at 2 and 6 months after RIT. Response was assessed by using the
      International Workshop Criteria (IWC) and revised criteria (IWC + PET) as well as
      the criteria of the European Organization for Research and Treatment of Cancer.
      One-way analysis of variance for repeated measures, receiver operator curve
      analysis, and Kaplan-Meier curves were used for statistical analysis. RESULTS:
      PET/CT performed at 2 months revealed complete (n = 12) or partial (n = 4)
      metabolic response in 16 of 23 patients with complete or partial clinical
      response. These findings were all confirmed at 6-month scanning. PET/CT indicated
      refractory or persistent disease at 2 and 6 months in the remaining seven
      patients. Better overall survival was observed for patients with a reduction in
      the maximum standard uptake value of 49% or higher (both at 2 and 6 months after 
      RIT) when compared with those with a decrease of less than 49% (P < .05).
      CONCLUSION: Early assessment of response to RIT by using PET/CT might be useful
      in the identification of patients needing additional therapeutic strategies.
FAU - Storto, Giovanni
AU  - Storto G
AD  - Istituto di Ricerca e Cura a Carattere Scientifico, Universita Federico II, Via
      Pansini 5, 80131 Naples, Italy. giosto24@hotmail.com
FAU - De Renzo, Amalia
AU  - De Renzo A
FAU - Pellegrino, Teresa
AU  - Pellegrino T
FAU - Perna, Fabiana
AU  - Perna F
FAU - De Falco, Teresa
AU  - De Falco T
FAU - Erra, Paola
AU  - Erra P
FAU - Nardelli, Anna
AU  - Nardelli A
FAU - Speranza, Antonio
AU  - Speranza A
FAU - Klain, Michele
AU  - Klain M
FAU - Rotoli, Bruno
AU  - Rotoli B
FAU - Pace, Leonardo
AU  - Pace L
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Radiopharmaceuticals)
RN  - 0 (Yttrium Radioisotopes)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
RN  - 4Q52C550XK (ibritumomab tiuxetan)
SB  - IM
MH  - Aged
MH  - Analysis of Variance
MH  - Antibodies, Monoclonal/*therapeutic use
MH  - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
MH  - Female
MH  - Fluorodeoxyglucose F18
MH  - Humans
MH  - Lymphoma, B-Cell/diagnostic imaging/*radiotherapy
MH  - Male
MH  - Positron-Emission Tomography/methods
MH  - Prospective Studies
MH  - ROC Curve
MH  - Radiographic Image Interpretation, Computer-Assisted
MH  - Radioimmunotherapy/*methods
MH  - Radiopharmaceuticals
MH  - Survival Rate
MH  - Tomography, X-Ray Computed/methods
MH  - Treatment Outcome
MH  - Yttrium Radioisotopes
EDAT- 2009/12/25 06:00
MHDA- 2010/01/27 06:00
CRDT- 2009/12/25 06:00
PHST- 2009/12/25 06:00 [entrez]
PHST- 2009/12/25 06:00 [pubmed]
PHST- 2010/01/27 06:00 [medline]
AID - 254/1/245 [pii]
AID - 10.1148/radiol.09090603 [doi]
PST - ppublish
SO  - Radiology. 2010 Jan;254(1):245-52. doi: 10.1148/radiol.09090603.


PMID- 20032154
OWN - NLM
STAT- MEDLINE
DCOM- 20100126
LR  - 20091224
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 254
IP  - 1
DP  - 2010 Jan
TI  - Alzheimer disease: functional abnormalities in the dorsal visual pathway.
PG  - 219-26
LID - 10.1148/radiol.2541090558 [doi]
AB  - PURPOSE: To evaluate whether patients with Alzheimer disease (AD) have altered
      activation compared with age-matched healthy control (HC) subjects during a task 
      that typically recruits the dorsal visual pathway. MATERIALS AND METHODS: The
      study was performed in accordance with the Declaration of Helsinki, with
      institutional ethics committee approval, and all subjects provided written
      informed consent. Two tasks were performed to investigate neural function: face
      matching and location matching. Twelve patients with mild AD and 14 age-matched
      HC subjects were included. Brain activation was measured by using functional
      magnetic resonance imaging. Group statistical analyses were based on a
      mixed-effects model corrected for multiple comparisons. RESULTS: Task performance
      was not statistically different between the two groups, and within groups there
      were no differences in task performance. In the HC group, the visual perception
      tasks selectively activated the visual pathways. Conversely in the AD group,
      there was no selective activation during performance of these same tasks. Along
      the dorsal visual pathway, the AD group recruited additional regions, primarily
      in the parietal and frontal lobes, for the location-matching task. There were no 
      differences in activation between groups during the face-matching task.
      CONCLUSION: The increased activation in the AD group may represent a compensatory
      mechanism for decreased processing effectiveness in early visual areas of
      patients with AD. The findings support the idea that the dorsal visual pathway is
      more susceptible to putative AD-related neuropathologic changes than is the
      ventral visual pathway.
FAU - Bokde, Arun L W
AU  - Bokde AL
AD  - Discipline of Psychiatry, School of Medicine and Trinity College Institute of
      Neuroscience, Laboratory of Neuroimaging and Biomarker Research, Trinity College 
      Dublin, Adelaide and Meath Hospital incorporating National Children's Hospital,
      Dublin, Ireland. Arun.Bokde@tcd.ie
FAU - Lopez-Bayo, Patricia
AU  - Lopez-Bayo P
FAU - Born, Christine
AU  - Born C
FAU - Ewers, Michael
AU  - Ewers M
FAU - Meindl, Thomas
AU  - Meindl T
FAU - Teipel, Stefen J
AU  - Teipel SJ
FAU - Faltraco, Frank
AU  - Faltraco F
FAU - Reiser, Maximilian F
AU  - Reiser MF
FAU - Moller, Hans-Juergen
AU  - Moller HJ
FAU - Hampel, Harald
AU  - Hampel H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alzheimer Disease/*physiopathology
MH  - Brain Mapping
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Neuropsychological Tests
MH  - Photic Stimulation
MH  - Task Performance and Analysis
MH  - Visual Cortex/*physiopathology
MH  - Visual Perception/*physiology
EDAT- 2009/12/25 06:00
MHDA- 2010/01/27 06:00
CRDT- 2009/12/25 06:00
PHST- 2009/12/25 06:00 [entrez]
PHST- 2009/12/25 06:00 [pubmed]
PHST- 2010/01/27 06:00 [medline]
AID - 254/1/219 [pii]
AID - 10.1148/radiol.2541090558 [doi]
PST - ppublish
SO  - Radiology. 2010 Jan;254(1):219-26. doi: 10.1148/radiol.2541090558.


PMID- 20032145
OWN - NLM
STAT- MEDLINE
DCOM- 20100126
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 254
IP  - 1
DP  - 2010 Jan
TI  - Intrinsic susceptibility MR imaging of chemically induced rat mammary tumors:
      relationship to histologic assessment of hypoxia and fibrosis.
PG  - 110-8
LID - 10.1148/radiol.2541090395 [doi]
AB  - PURPOSE: To investigate relationships between magnetic resonance (MR) imaging
      measurements of R2* and carbogen-induced DeltaR2* in vivo with subsequent
      histologic assessment of grade, hypoxia, fibrosis, and necrosis in a chemically
      induced rat mammary tumor model. MATERIALS AND METHODS: All experiments were
      performed in accordance with the local ethics review panel, the UK Home Office
      Animals Scientific Procedures Act of 1986, and the UK Co-ordinating Committee on 
      Cancer Research guidelines. Of 30 rats injected with N-methyl-N-nitrosourea, 17
      developed mammary tumors. Prior to MR imaging, rats were administered
      pimonidazole. Tumor R2* was then quantified while the host first breathed air and
      then carbogen (95% O(2), 5% CO(2); n = 16). Tumor sections were subsequently
      stained for pimonidazole, sirius red, cytokeratin 14, and hematoxylin-eosin for
      quantitative assessment of hypoxia, fibrosis, malignancy, and necrosis,
      respectively, and graded according to the Scarff-Bloom-Richardson scale. Linear
      regression analysis was used to identify any correlates of the MR imaging data
      with histologic data. RESULTS: Tumors exhibited wide heterogeneity in the
      magnitude of carbogen-induced reduction in R2*, an emerging imaging biomarker of 
      fractional blood volume. Significant correlations were found between pimonidazole
      adduct formation and both baseline tumor R2* (r = -0.54, P = .03) and
      carbogen-induced DeltaR2* (r = 0.56, P = .02), demonstrating that tumors with a
      larger fractional blood volume were less hypoxic. There was also a significant
      correlation between pimonidazole and sirius red staining (r = 0.76, P < .01),
      indicating that more fibrotic tumors were also more hypoxic. There were no
      correlations of R2* with grade. CONCLUSION: In this model of breast cancer,
      baseline tumor R2* and carbogen-induced DeltaR2* are predictive imaging
      biomarkers for hypoxia and primarily determined by blood volume.
FAU - McPhail, Lesley D
AU  - McPhail LD
AD  - Cancer Research UK Clinical Magnetic Resonance Research Group, The Institute of
      Cancer Research, Sutton, Surrey SM2 5PT, England.
FAU - Robinson, Simon P
AU  - Robinson SP
LA  - eng
GR  - C16412/A6269/Cancer Research UK/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Keratin-14)
RN  - 0 (Nitroimidazoles)
RN  - 0 (Radiation-Sensitizing Agents)
RN  - 142M471B3J (Carbon Dioxide)
RN  - 46JO4D76R2 (pimonidazole)
RN  - 684-93-5 (Methylnitrosourea)
RN  - 8063-77-2 (carbogen)
RN  - S88TT14065 (Oxygen)
SB  - IM
CIN - Radiology. 2010 Jan;254(1):1-3. PMID: 20032129
MH  - Animals
MH  - Biomarkers, Tumor/metabolism
MH  - Carbon Dioxide/pharmacology
MH  - Female
MH  - Fibrosis/pathology
MH  - Hypoxia/pathology
MH  - Keratin-14/metabolism
MH  - Linear Models
MH  - Magnetic Resonance Imaging/*methods
MH  - Mammary Neoplasms, Experimental/*chemically induced/metabolism/pathology
MH  - Methylnitrosourea
MH  - Necrosis/pathology
MH  - Nitroimidazoles/pharmacology
MH  - Oxygen/pharmacology
MH  - Radiation-Sensitizing Agents/pharmacology
MH  - Rats
MH  - Rats, Wistar
EDAT- 2009/12/25 06:00
MHDA- 2010/01/27 06:00
CRDT- 2009/12/25 06:00
PHST- 2009/12/25 06:00 [entrez]
PHST- 2009/12/25 06:00 [pubmed]
PHST- 2010/01/27 06:00 [medline]
AID - 254/1/110 [pii]
AID - 10.1148/radiol.2541090395 [doi]
PST - ppublish
SO  - Radiology. 2010 Jan;254(1):110-8. doi: 10.1148/radiol.2541090395.


PMID- 20032144
OWN - NLM
STAT- MEDLINE
DCOM- 20100126
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 254
IP  - 1
DP  - 2010 Jan
TI  - Acute myocardial infarction: serial cardiac MR imaging shows a decrease in
      delayed enhancement of the myocardium during the 1st week after reperfusion.
PG  - 88-97
LID - 10.1148/radiol.09090660 [doi]
AB  - PURPOSE: To evaluate the time course of delayed gadolinium enhancement of
      infarcted myocardium by using serial contrast agent-enhanced (CE) cardiac
      magnetic resonance (MR) images obtained during the acute, subacute, and chronic
      stages of infarction. MATERIALS AND METHODS: The study protocol was reviewed and 
      approved by the local ethics committee, and written informed consent was
      obtained. Seventeen patients with reperfused acute myocardial infarction (AMI)
      underwent cine and CE cardiac MR a median of 1, 7, 35, and 180 days after
      reperfusion. Infarct size determined on the basis of delayed enhancement MR
      imaging at different times was compared by using nonparametric tests and
      Bland-Altman analysis. Extent of myocardial enhancement was compared with single 
      photon emission computed tomographic (SPECT) measures of infarct size with
      Spearman correlation. Regional myocardial enhancement extent and contractility
      were analyzed with nonparametric tests. RESULTS: Infarct size was 18.3% of total 
      myocardial LV volume on day 1 after AMI and decreased to 12.9% on day 7, 11.3% on
      day 35, and 11.6% on day 180 (all P < .001). Estimated infarct size on day 7, as 
      compared with day 1 enhancement size, declined by 57.1% within the epicardium and
      by 6.3% within the endocardium (both P < .001). Infarct size on day 7 showed only
      minor changes at subsequent imaging and yielded a high correlation with SPECT
      measurements of infarct size (r = 0.84). Infarct size on day 7 inversely
      correlated with long-term wall thickening (P < .0001) and allowed prediction of
      contractile function. CONCLUSION: In patients with AMI and successful coronary
      reperfusion, the size of delayed gadolinium enhancement at CE cardiac MR imaging 
      significantly diminished during the 1st week after infarction. Thus, timing of CE
      cardiac MR imaging is crucial for accurate measurement of myocardial infarct size
      early after AMI.
FAU - Ibrahim, Tareq
AU  - Ibrahim T
AD  - Department of Cardiology, Klinikums Rechts der Isar and German Heart Centre
      Munich, Munich, Germany. T.Ibrahim@lrz.tu-muenchen.de
FAU - Hackl, Thomas
AU  - Hackl T
FAU - Nekolla, Stephan G
AU  - Nekolla SG
FAU - Breuer, Martin
AU  - Breuer M
FAU - Feldmair, Michael
AU  - Feldmair M
FAU - Schomig, Albert
AU  - Schomig A
FAU - Schwaiger, Markus
AU  - Schwaiger M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - 0 (Radiopharmaceuticals)
RN  - 971Z4W1S09 (Technetium Tc 99m Sestamibi)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Contrast Media
MH  - Female
MH  - Gadolinium DTPA
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/diagnostic imaging/*pathology
MH  - Myocardial Reperfusion
MH  - Myocardium/*pathology
MH  - Radiopharmaceuticals
MH  - Statistics, Nonparametric
MH  - Technetium Tc 99m Sestamibi
MH  - Tomography, Emission-Computed, Single-Photon
EDAT- 2009/12/25 06:00
MHDA- 2010/01/27 06:00
CRDT- 2009/12/25 06:00
PHST- 2009/12/25 06:00 [entrez]
PHST- 2009/12/25 06:00 [pubmed]
PHST- 2010/01/27 06:00 [medline]
AID - 254/1/88 [pii]
AID - 10.1148/radiol.09090660 [doi]
PST - ppublish
SO  - Radiology. 2010 Jan;254(1):88-97. doi: 10.1148/radiol.09090660.


PMID- 20030772
OWN - NLM
STAT- MEDLINE
DCOM- 20110217
LR  - 20220310
IS  - 1471-6712 (Electronic)
IS  - 0283-9318 (Linking)
VI  - 24
IP  - 3
DP  - 2010 Sep
TI  - How to cope with the mask? Experiences of mask treatment in patients with acute
      chronic obstructive pulmonary disease-exacerbations.
PG  - 499-506
LID - 10.1111/j.1471-6712.2009.00740.x [doi]
AB  - The aim of the study was to focus on important aspects and issues associated with
      bi-level positive airway pressure (BPAP) mask treatment in acute exacerbation of 
      chronic obstructive pulmonary disease based on the experiences of patients and
      nurses. The study has a qualitative design with a phenomenological approach. The 
      data are based on qualitative in-depth interviews with five patients who had used
      BPAP-mask treatment intermittently over several days in the acute stages and a
      focus group with eight experienced nurses from a specialized unit in a Norwegian 
      university hospital. The data have been analysed on the basis of Amadeo Giorgi's 
      phenomenological method. Findings are discussed in the light of the Norwegian
      philosopher Kari Martinsen's nursing philosophy with practical implications. The 
      essential structure of being treated with BPAP-mask from the patients' point of
      view may be characterised as a feeling of being trapped in a situation of
      complete dependence on others, combined with a will to mobilize inner strength.
      The essential structure is presented through three themes describing the
      patient's lived experience: Anxiety, panic and loss of control, regaining control
      and trust through skilled help, and a mobilization of willpower. The nurses'
      experiences point to the challenges related to individual needs, ethics,
      technical, medical and relational competence in addition to constraints on time. 
      The study concludes that mask treatment can be a traumatic experience for the
      patients. The interplay between dependence and autonomy in the patient's
      interaction with health care providers, such as deciding when to take breaks,
      getting enough sleep, mobilizing inner strength and establishing trust and
      security are important factors in coping with the mask. Clinical competence, the 
      ability to articulate impressions, and sufficient time on the part of health
      workers are other aspects that can be decisive to how well the patient tolerates 
      BPAP-mask treatment.
CI  - (c) 2009 The Authors. Journal compilation (c) 2009 Nordic College of Caring
      Science.
FAU - Torheim, Henny
AU  - Torheim H
AD  - Department of Intensive Care Nursing, Hospital of Volda, Volda, Norway.
      henny@tussa.com
FAU - Gjengedal, Eva
AU  - Gjengedal E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Sweden
TA  - Scand J Caring Sci
JT  - Scandinavian journal of caring sciences
JID - 8804206
MH  - *Adaptation, Psychological
MH  - Humans
MH  - *Laryngeal Masks
MH  - Nurse-Patient Relations
MH  - Pulmonary Disease, Chronic Obstructive/physiopathology/psychology/*therapy
MH  - Trust
EDAT- 2009/12/25 06:00
MHDA- 2011/02/18 06:00
CRDT- 2009/12/25 06:00
PHST- 2009/12/25 06:00 [entrez]
PHST- 2009/12/25 06:00 [pubmed]
PHST- 2011/02/18 06:00 [medline]
AID - SCS740 [pii]
AID - 10.1111/j.1471-6712.2009.00740.x [doi]
PST - ppublish
SO  - Scand J Caring Sci. 2010 Sep;24(3):499-506. doi:
      10.1111/j.1471-6712.2009.00740.x.


PMID- 20029349
OWN - NLM
STAT- MEDLINE
DCOM- 20100421
LR  - 20100325
IS  - 1530-0293 (Electronic)
IS  - 0090-3493 (Linking)
VI  - 38
IP  - 4 Suppl
DP  - 2010 Apr
TI  - Clinical research ethics for critically ill patients: a pandemic proposal.
PG  - e138-42
LID - 10.1097/CCM.0b013e3181cbaff4 [doi]
AB  - Pandemic H1N1 influenza is projected to be unprecedented in its scope, causing
      acute critical illness among thousands of young otherwise healthy adults, who
      will need advanced life support. Rigorous, relevant, timely, and ethical clinical
      and health services research is crucial to improve their care and outcomes.
      Studies designed and conducted during a pandemic should be held to the same high 
      methodologic and implementation standards as during other times. However, unique 
      challenges arise with the need to conduct investigations as efficiently as
      possible, focused on the optimal outcome for the individual patient, while
      balancing the need for maximal societal benefit. We believe that clinical
      critical care research during a pandemic must be approached differently from
      research undertaken under nonemergent circumstances. We propose recommendations
      to clinical investigators and research ethics committees regarding clinical and
      health services research on pandemic-related critical illness. We also propose
      strategies such as expedited and centralized research ethics committee reviews
      and alternate consent models.
FAU - Cook, Deborah
AU  - Cook D
AD  - International Forum for Acute Care Trialists (InFACT) Ethics Committee,
      Department of Medicine, McMaster University, Hamilton, Canada.
      debcook@mcmaster.ca
FAU - Burns, Karen
AU  - Burns K
FAU - Finfer, Simon
AU  - Finfer S
FAU - Kissoon, Niranjan
AU  - Kissoon N
FAU - Bhagwanjee, Satish
AU  - Bhagwanjee S
FAU - Annane, Djillali
AU  - Annane D
FAU - Sprung, Charles L
AU  - Sprung CL
FAU - Fowler, Rob
AU  - Fowler R
FAU - Latronico, Nicola
AU  - Latronico N
FAU - Marshall, John
AU  - Marshall J
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Crit Care Med
JT  - Critical care medicine
JID - 0355501
SB  - IM
MH  - *Critical Illness
MH  - *Disease Outbreaks
MH  - Ethics Committees, Research
MH  - *Ethics, Research
MH  - Humans
MH  - *Influenza A Virus, H1N1 Subtype
MH  - *Influenza, Human
MH  - Informed Consent
EDAT- 2009/12/24 06:00
MHDA- 2010/04/22 06:00
CRDT- 2009/12/24 06:00
PHST- 2009/12/24 06:00 [entrez]
PHST- 2009/12/24 06:00 [pubmed]
PHST- 2010/04/22 06:00 [medline]
AID - 10.1097/CCM.0b013e3181cbaff4 [doi]
PST - ppublish
SO  - Crit Care Med. 2010 Apr;38(4 Suppl):e138-42. doi: 10.1097/CCM.0b013e3181cbaff4.


PMID- 20029345
OWN - NLM
STAT- MEDLINE
DCOM- 20100222
LR  - 20220317
IS  - 1530-0293 (Electronic)
IS  - 0090-3493 (Linking)
VI  - 38
IP  - 2
DP  - 2010 Feb
TI  - Different assessment tools for intensive care unit delirium: which score to use?
PG  - 409-18
LID - 10.1097/CCM.0b013e3181cabb42 [doi]
AB  - OBJECTIVE: To compare validity and reliability of three instruments for detection
      and assessment of delirium in intensive care unit (ICU) patients. Delirium in
      critically ill patients is associated with higher mortality, prolonged duration
      of ICU stay, and greater healthcare costs. Currently, there are several
      assessment tools available for detection of delirium, but only a few of these
      assessment systems are developed specifically to screen for delirium in ICU
      patients. DESIGN: Prospective cohort study. SETTING: ICU at a university
      hospital. PATIENTS: A total of 156 surgical patients aged > or = 60 yrs
      consecutively admitted to the ICU, with a length of stay of at least 24 hrs.
      MEASUREMENTS AND MAIN RESULTS: This study was approved by the institutional
      ethics committee. Trained staff members performed daily and independently the
      Confusion Assessment Method for the ICU (CAM-ICU), the Nursing Delirium Screening
      Scale (Nu-DESC), and the Delirium Detection Score (DDS). These evaluations were
      compared against the reference standard conducted by a delirium expert (blinded
      to the study), who used delirium criteria from the Diagnostic and Statistical
      Manual of Mental Disorders, Fourth Edition (DSM-IV). Of 156 patients, 63 (40%)
      were identified as delirious by the reference standard during the study. Using
      the CAM-ICU and the Nu-DESC, we measured comparable sensitivities (CAM-ICU, 81%; 
      Nu-DESC, 83%). The specificity of the CAM-ICU was significantly higher than that 
      of the Nu-DESC (96% vs. 81%, p < .01). In contrast, the DDS showed poor
      sensitivity (30%), whereas the specificity was significantly higher compared with
      the Nu-DESC (DDS, 91%; Nu-DESC, 81%, p < .05). The interrater reliability was
      "almost perfect" for the CAM-ICU (kappa = 0.89) and "substantial" for DDS and
      Nu-DESC (kappa = 0.79, 0.68). CONCLUSION: The CAM-ICU showed the best validity of
      the evaluated scales to identify delirium in ICU patients. The Nu-DESC might be
      an alternative tool for detection of ICU delirium. The DDS should not be used as 
      a screening tool.
FAU - Luetz, Alawi
AU  - Luetz A
AD  - Department of Anesthesiology and Intensive Care Medicine, Campus
      Virchow-Klinikum, Charite-Universitaetsmedizin Berlin, Berlin, Germany.
FAU - Heymann, Anja
AU  - Heymann A
FAU - Radtke, Finn M
AU  - Radtke FM
FAU - Chenitir, Chokri
AU  - Chenitir C
FAU - Neuhaus, Ulrike
AU  - Neuhaus U
FAU - Nachtigall, Irit
AU  - Nachtigall I
FAU - von Dossow, Vera
AU  - von Dossow V
FAU - Marz, Susanne
AU  - Marz S
FAU - Eggers, Verena
AU  - Eggers V
FAU - Heinz, Andreas
AU  - Heinz A
FAU - Wernecke, Klaus D
AU  - Wernecke KD
FAU - Spies, Claudia D
AU  - Spies CD
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Crit Care Med
JT  - Critical care medicine
JID - 0355501
SB  - IM
CIN - Crit Care Med. 2010 Feb;38(2):693-4. PMID: 20083928
CIN - Crit Care Med. 2010 Jul;38(7):1610-1; author reply 1611-2. PMID: 20562551
EIN - Crit Care Med. 2010 Jun;38(6):1509
MH  - Aged
MH  - Delirium/*diagnosis
MH  - Female
MH  - Humans
MH  - *Intensive Care Units
MH  - Male
MH  - Middle Aged
MH  - Observer Variation
MH  - Postoperative Complications/diagnosis/psychology
MH  - Prospective Studies
MH  - Psychiatric Status Rating Scales/standards
MH  - Reproducibility of Results
MH  - Treatment Outcome
EDAT- 2009/12/24 06:00
MHDA- 2010/02/23 06:00
CRDT- 2009/12/24 06:00
PHST- 2009/12/24 06:00 [entrez]
PHST- 2009/12/24 06:00 [pubmed]
PHST- 2010/02/23 06:00 [medline]
AID - 10.1097/CCM.0b013e3181cabb42 [doi]
PST - ppublish
SO  - Crit Care Med. 2010 Feb;38(2):409-18. doi: 10.1097/CCM.0b013e3181cabb42.


PMID- 20029004
OWN - NLM
STAT- MEDLINE
DCOM- 20110505
LR  - 20151119
IS  - 1472-0213 (Electronic)
IS  - 1472-0205 (Linking)
VI  - 27
IP  - 1
DP  - 2010 Jan
TI  - Evaluation of morning report in an emergency medicine department.
PG  - 32-6
LID - 10.1136/emj.2008.067256 [doi]
AB  - BACKGROUND: Morning report is considered as an important educational tool in
      different branches of medicine. The purpose of the present study was to examine
      the method of case selection, the leadership, the participant's satisfaction and 
      the educational value of morning report held in our centre. METHOD: In September 
      2007, a formal feedback about the morning report was provided by questionnaire
      surveys. The data on the method of case selection, the leadership, the
      participant's satisfaction and the educational value of the sessions were
      collected from the residents, medical students and the academic staff in
      emergency medicine department. Each questionnaire also contained an open-ended
      question, asking for the responders' suggestions for improving these sessions.
      RESULTS: 73.2% of the responders were satisfied with the current model of the
      conference hall. The data showed that 46.3% of the participants believed these
      sessions are held for giving the medical team the required information and 65.9% 
      for solving the patient's problems. The data showed that the participants had
      evaluated the presentation strategy to be good; however, the presentation pattern
      was reported to be traditional and based on differential diagnosis in 53.7% of
      the cases and modern problem oriented in only 39%. CONCLUSION: Most participants 
      considered morning report sessions held in our hospital to be effective in the
      way it is; however, issues such as communication skill, emergency department
      management, critical thinking, ethics, professionalism and evidence-based
      medicine should also be added to the sessions.
FAU - Moharari, R S
AU  - Moharari RS
AD  - Research and Development Center, Sina Hospital, Imam Khomeini St, Tehran 11367,
      Iran. patricia.kh@gmail.com
FAU - Soleymani, H A
AU  - Soleymani HA
FAU - Nejati, A
AU  - Nejati A
FAU - Rezaeefar, A
AU  - Rezaeefar A
FAU - Khashayar, P
AU  - Khashayar P
FAU - Meysamie, A P
AU  - Meysamie AP
LA  - eng
PT  - Journal Article
PL  - England
TA  - Emerg Med J
JT  - Emergency medicine journal : EMJ
JID - 100963089
SB  - IM
MH  - Adult
MH  - Attitude of Health Personnel
MH  - *Communication
MH  - Emergency Medicine/*education
MH  - Emergency Service, Hospital
MH  - Health Care Surveys
MH  - Hospitals, General
MH  - Humans
MH  - Iran
MH  - Job Satisfaction
MH  - Medical Staff, Hospital/*education
MH  - Models, Educational
MH  - Surveys and Questionnaires
EDAT- 2009/12/24 06:00
MHDA- 2011/05/06 06:00
CRDT- 2009/12/24 06:00
PHST- 2009/12/24 06:00 [entrez]
PHST- 2009/12/24 06:00 [pubmed]
PHST- 2011/05/06 06:00 [medline]
AID - 27/1/32 [pii]
AID - 10.1136/emj.2008.067256 [doi]
PST - ppublish
SO  - Emerg Med J. 2010 Jan;27(1):32-6. doi: 10.1136/emj.2008.067256.


PMID- 20027121
OWN - NLM
STAT- MEDLINE
DCOM- 20100405
LR  - 20100121
IS  - 1536-0210 (Electronic)
IS  - 0020-9996 (Linking)
VI  - 45
IP  - 2
DP  - 2010 Feb
TI  - Saving dose in triple-rule-out computed tomography examination using a high-pitch
      dual spiral technique.
PG  - 64-71
LID - 10.1097/RLI.0b013e3181c15842 [doi]
AB  - OBJECTIVE: High radiation doses remain a drawback of current triple-rule-out
      computed tomography (CT) protocols. With dual source CT, a new high-pitch dual
      spiral technique offers the possibility to acquire an Electrocardiography
      (ECG)-gated-synchronized dataset of the whole chest in less than 1 second. The
      aim of this study was to compare the dose of such a protocol to a standard,
      nongated chest scan and to a conventional, retrospectively ECG-gated
      triple-rule-out protocol. Also, the efficacy and dose of this dual spiral
      protocol was to be compared in patients examined with this high-pitch technique
      and matched controls scanned with the conventional technique. MATERIALS AND
      METHODS: An anthropomorphic Alderson Rando phantom was equipped with
      thermoluminescent detectors and scanned with the high-pitch protocol (Siemens
      Somatom Definition Flash; 2 x 120 kVp, 426 mAseff, 128 x 0.6 mm collimation,
      pitch 3.2), the nongated chest scan (same scanner; 120 kVp, 160 mAseff, 128 x 0.6
      mm, pitch 1.2; equivalent Computed Tomography Dose Index (CTDI) of 7.12 mGy), and
      the conventional gating technique (Siemens Somatom Definition; 120 kVp, 560
      mAseff with ECG pulsing interval at 30%-70% of the R-R cycle, 64 x 0.6 mm, pitch 
      0.3). Noise was measured in air, central and peripheral soft tissue of the
      phantom. Conversion factors were determined based on the measured dose and the
      dose-length products of the scanner. The protocol was then applied with ethics
      committee approval in 31 patients suffering from acute chest pain. The 120 mL of 
      contrast material (Ultravist 370, Bayer Schering Pharma) was applied at 5 mL/s.
      Dose was calculated based on the dose-length products and the conversion factor. 
      Image quality was assessed by 2 readers for aorta, pulmonary arteries, and
      coronary arteries. The results were compared with matched controls scanned with
      the conventional ECG gating technique and non-ECG gated thorax scans. RESULTS:
      The dose determined with thermoluminescent dosimeters measurements amounted to
      2.65, 2.68, and 19.27 mSv, respectively, for the dual spiral technique, the
      standard chest scan, and the conventional retrospective technique. There was no
      significant difference in image noise. Respective conversion factors were 0.0186,
      0.0188, and 0.0180 mSv/mGy x cm. In the patient examinations, dose was 4.08 +/-
      0.81 mSv with the high-pitch protocol compared with 20.4 +/- 5.3 mSv in the
      matched controls with the conventional technique, and 4.40 +/- 0.83 mSv for the
      non-ECG gated thorax scan. Scan times were 0.7 +/- 0.1 seconds for the high-pitch
      scan and 15 +/- 3 seconds for the conventional chest pain scan. Aorta and
      pulmonary arteries were depicted in diagnostic quality in both groups. About
      84.7% of coronary artery segments were rated as diagnostic in the high-pitch
      exams (95.4% below 65 bpm and only 72.8% in higher heart rates), whereas 92.9%
      were diagnostic with the conventional approach. CONCLUSION: The high-pitch dual
      spiral technique requires only about one-fifth of the dose of conventional ECG
      gated triple-rule-out protocols, thus matching that of a standard nongated chest 
      scan. With less than 1 second, the scan time is very short. This protocol can be 
      recommended for patients with unclear chest pain with rhythmic heart rates below 
      65 bpm.
FAU - Sommer, Wieland H
AU  - Sommer WH
AD  - Departments of Clinical Radiology and daggerRadiotherapy and Radiooncology,
      University Hospitals-Grosshadern, Ludwig-Maximilians University, Munich, Germany.
      wieland.sommer@med.uni-muenchen.de
FAU - Schenzle, Jan C
AU  - Schenzle JC
FAU - Becker, Christoph R
AU  - Becker CR
FAU - Nikolaou, Konstantin
AU  - Nikolaou K
FAU - Graser, Anno
AU  - Graser A
FAU - Michalski, Gisela
AU  - Michalski G
FAU - Neumaier, Klement
AU  - Neumaier K
FAU - Reiser, Maximilian F
AU  - Reiser MF
FAU - Johnson, Thorsten R C
AU  - Johnson TR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Invest Radiol
JT  - Investigative radiology
JID - 0045377
SB  - IM
MH  - Aged
MH  - Cardiac-Gated Imaging Techniques/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Phantoms, Imaging
MH  - *Radiation Dosage
MH  - Radiation Protection/*methods
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Tomography, Spiral Computed/instrumentation/*methods
EDAT- 2009/12/23 06:00
MHDA- 2010/04/07 06:00
CRDT- 2009/12/23 06:00
PHST- 2009/12/23 06:00 [entrez]
PHST- 2009/12/23 06:00 [pubmed]
PHST- 2010/04/07 06:00 [medline]
AID - 10.1097/RLI.0b013e3181c15842 [doi]
PST - ppublish
SO  - Invest Radiol. 2010 Feb;45(2):64-71. doi: 10.1097/RLI.0b013e3181c15842.


PMID- 20026722
OWN - NLM
STAT- MEDLINE
DCOM- 20100222
LR  - 20191210
IS  - 1552-7409 (Electronic)
IS  - 0894-3184 (Linking)
VI  - 23
IP  - 1
DP  - 2010 Jan
TI  - Nursing ethics and power in position.
PG  - 18-21
LID - 10.1177/0894318409353812 [doi]
AB  - Power in positions of authority and responsibility may be manifested in myriad
      ways in management positions, with all businesses and disciplines, including the 
      discipline of nursing. From the nursing disciplinary theoretical perspective of
      humanbecoming, this column begins a discussion regarding the obligations of
      healthcare disciplines to address the ethical questions of what should and ought 
      members of healthcare disciplines be doing to enhance the quality and integrity
      for healthcare recipients' experiences. Exercising power judiciously and with
      transparency will be defined and emphasized as important for members of
      healthcare disciplines, for preserving and protecting the legacy of future
      healthcare leaders.
FAU - Milton, Constance L
AU  - Milton CL
AD  - California Baptist University, Riverside, CA 92504, USA.
      constancemilton@yahoo.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Nurs Sci Q
JT  - Nursing science quarterly
JID - 8805022
MH  - Choice Behavior/ethics
MH  - Coercion
MH  - Global Health
MH  - Human Development
MH  - Humans
MH  - *Leadership
MH  - Machiavellianism
MH  - Nurse Administrators/*ethics
MH  - *Nurse's Role
MH  - *Nursing Theory
MH  - Patient Advocacy/ethics
MH  - Persuasive Communication
MH  - *Power, Psychological
MH  - Quality of Health Care/ethics
MH  - Social Responsibility
MH  - Truth Disclosure/ethics
EDAT- 2009/12/23 06:00
MHDA- 2010/02/23 06:00
CRDT- 2009/12/23 06:00
PHST- 2009/12/23 06:00 [entrez]
PHST- 2009/12/23 06:00 [pubmed]
PHST- 2010/02/23 06:00 [medline]
AID - 23/1/18 [pii]
AID - 10.1177/0894318409353812 [doi]
PST - ppublish
SO  - Nurs Sci Q. 2010 Jan;23(1):18-21. doi: 10.1177/0894318409353812.


PMID- 20026695
OWN - NLM
STAT- MEDLINE
DCOM- 20100428
LR  - 20161125
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 1
DP  - 2010 Jan
TI  - Medical ethics and law for doctors of tomorrow: the 1998 Consensus Statement
      updated.
PG  - 55-60
LID - 10.1136/jme.2009.034660 [doi]
AB  - Knowledge of the ethical and legal basis of medicine is as essential to clinical 
      practice as an understanding of basic medical sciences. In the UK, the General
      Medical Council (GMC) requires that medical graduates behave according to ethical
      and legal principles and must know about and comply with the GMC's ethical
      guidance and standards. We suggest that these standards can only be achieved when
      the teaching and learning of medical ethics, law and professionalism are
      fundamental to, and thoroughly integrated both vertically and horizontally
      throughout, the curricula of all medical schools as a shared obligation of all
      teachers. The GMC also requires that each medical school provides adequate
      teaching time and resources to achieve the above. We reiterate that the adequate 
      provision and coordination of teaching and learning of ethics and law requires at
      least one full-time senior academic in ethics and law with relevant professional 
      and academic expertise. In this paper we set out an updated indicative core
      content of learning for medical ethics and law in UK medical schools and describe
      its origins and the consultative process by which it was achieved.
FAU - Stirrat, G M
AU  - Stirrat GM
AD  - Centre for Ethics in Medicine, Hampton House, Cotham Hill, Bristol BS6 6AU, UK.
      g.m.stirrat@bristol.ac.uk.
FAU - Johnston, C
AU  - Johnston C
FAU - Gillon, R
AU  - Gillon R
FAU - Boyd, K
AU  - Boyd K
CN  - Medical Education Working Group of Institute of Medical Ethics and associated
      signatories
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
CIN - J Med Ethics. 2010 Aug;36(8):511. PMID: 20663771
MH  - *Clinical Medicine/education/legislation & jurisprudence
MH  - Consensus
MH  - Curriculum/standards
MH  - Education, Medical, Undergraduate/*methods/standards
MH  - Ethics, Medical/*education
MH  - Humans
MH  - Schools, Medical/*standards
MH  - United Kingdom
EDAT- 2009/12/23 06:00
MHDA- 2010/04/29 06:00
CRDT- 2009/12/23 06:00
PHST- 2009/12/23 06:00 [entrez]
PHST- 2009/12/23 06:00 [pubmed]
PHST- 2010/04/29 06:00 [medline]
AID - 36/1/55 [pii]
AID - 10.1136/jme.2009.034660 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Jan;36(1):55-60. doi: 10.1136/jme.2009.034660.


PMID- 20026694
OWN - NLM
STAT- MEDLINE
DCOM- 20100428
LR  - 20091222
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 1
DP  - 2010 Jan
TI  - A practical approach to teaching medical ethics.
PG  - 50-4
LID - 10.1136/jme.2009.031153 [doi]
AB  - Teaching medical ethics and law has become much more prominent in medical student
      education, largely as a result of a 1998 consensus statement on such teaching.
      Ethics is commonly taught at undergraduate level using lectures and small group
      tutorials, but there is no recognised method for transferring this theoretical
      knowledge into practice and ward-based learning. This reflective article by a
      Sheffield university undergraduate medical student describes the value of using a
      student-selected component to study practical clinical ethics and the use of a
      clinical ethics checklist. The ethical checklist was proposed by Sokol as a tool 
      for use by medical staff during the ward round to prompt the consideration of
      important ethical principles in relation to care. This paper describes additional
      uses for the checklist as a tool for teaching and learning about the practical
      application of ethical principles and for observing professional behaviours
      within a critical care and acute care environment. Evidence suggests that putting
      ethical behaviour into practice offers a far greater challenge to a newly
      qualified doctor than has been appreciated, and that more needs to be done at an 
      undergraduate level to help combat this. This paper argues from a personal
      standpoint of an individual student experience that this can best be done in a
      clinical medical setting.
FAU - Mills, S
AU  - Mills S
AD  - University of Sheffield, Sheffield, UK.
FAU - Bryden, D C
AU  - Bryden DC
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Checklist
MH  - Clinical Medicine
MH  - *Education, Medical, Undergraduate
MH  - Ethics, Medical/*education
MH  - Humans
MH  - Teaching/*methods
EDAT- 2009/12/23 06:00
MHDA- 2010/04/29 06:00
CRDT- 2009/12/23 06:00
PHST- 2009/12/23 06:00 [entrez]
PHST- 2009/12/23 06:00 [pubmed]
PHST- 2010/04/29 06:00 [medline]
AID - 36/1/50 [pii]
AID - 10.1136/jme.2009.031153 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Jan;36(1):50-4. doi: 10.1136/jme.2009.031153.


PMID- 20026693
OWN - NLM
STAT- MEDLINE
DCOM- 20100428
LR  - 20211020
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 1
DP  - 2010 Jan
TI  - The role of 'public opinion' in the UK animal research debate.
PG  - 46-9
LID - 10.1136/jme.2009.030817 [doi]
AB  - Animal research remains a deeply controversial topic in biomedical science. While
      a vast amount has been written about the ethical status of laboratory animals,
      far less academic attention has been devoted to the public and, more
      specifically, to public opinion. Rather than what the public think, this article 
      considers the role of 'public opinion'. It draws on a recent empirical study
      which involved interviews with laboratory scientists who use animals in their
      research, and with other UK stakeholders. The first section of the paper
      demonstrates that public opinion has become a kind of resource in the animal
      research debate. Public opinion polls, in particular, are frequently cited. The
      second section explores this further and argues that, for all sides, appealing to
      public opinion is a key way to show legitimacy. Finally, the paper shifts gear to
      consider whether public opinion should matter, both for ethical reasoning and for
      science policy.
FAU - Hobson-West, P
AU  - Hobson-West P
AD  - Centre for Applied Bioethics, School of Veterinary Medicine and Science,
      University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire
      LE12 5RD. Pru.Hobson-West@nottingham.ac.uk
LA  - eng
GR  - 078876/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Animals
MH  - Animals, Laboratory
MH  - Biomedical Research/*ethics
MH  - Humans
MH  - Laboratory Animal Science/*ethics
MH  - *Public Opinion
MH  - United Kingdom
PMC - PMC5027911
MID - EMS69911
COIS- None. Provenance and peer review: Not commissioned; externally peer reviewed.
EDAT- 2009/12/23 06:00
MHDA- 2010/04/29 06:00
CRDT- 2009/12/23 06:00
PHST- 2009/12/23 06:00 [entrez]
PHST- 2009/12/23 06:00 [pubmed]
PHST- 2010/04/29 06:00 [medline]
AID - 36/1/46 [pii]
AID - 10.1136/jme.2009.030817 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Jan;36(1):46-9. doi: 10.1136/jme.2009.030817.


PMID- 20026690
OWN - NLM
STAT- MEDLINE
DCOM- 20100428
LR  - 20091222
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 1
DP  - 2010 Jan
TI  - The right not to know and preimplantation genetic diagnosis for Huntington's
      disease.
PG  - 30-3
LID - 10.1136/jme.2009.031047 [doi]
AB  - The right not to know is underappreciated in policy-making. Despite its
      articulation in medical law and ethics, policy-makers too easily let other
      concerns override the right not to know. This observation is triggered by a
      recent decision of the Dutch government on embryo selection for Huntington's
      disease. This is a monogenetic debilitating disease without cure, leading to
      death in early middle age, and thus is a likely candidate for preimplantation
      genetic diagnosis (PGD). People possibly affected with the Huntington gene do not
      always want to know their genetic status themselves, which is very burdensome
      knowledge. For prospective parents, this creates a difficulty in having
      unaffected children through embryo selection without knowing their own genetic
      status. A solution is provided by the exclusion test: it allows embryo selection 
      while honouring the parents' right not to know. The Dutch government however
      disallowed the exclusion test and chose to allow PGD on Huntington only for
      parents who test themselves first. To avoid "unnecessary" in-vitro fertilisation 
      procedures for unaffected parents, prospective parents are "forced to know"
      before they can conceive through embryo selection. This article analyses the
      scope of the right not to know in the context of embryo selection against
      Huntington's disease. It concludes that the right not to know implies that PGD
      against Huntington should be allowed by means of the exclusion test.
FAU - Asscher, E
AU  - Asscher E
AD  - Erasmus Medical Centre, Erasmus University, Rotterdam, The Netherlands.
      e.asscher@erasmusmc.nl
FAU - Koops, B-J
AU  - Koops BJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Confidentiality
MH  - Embryo Transfer
MH  - *Ethics, Medical
MH  - Female
MH  - Genetic Counseling/*ethics
MH  - Humans
MH  - Huntington Disease/*diagnosis/*genetics
MH  - Pregnancy
MH  - *Preimplantation Diagnosis
EDAT- 2009/12/23 06:00
MHDA- 2010/04/29 06:00
CRDT- 2009/12/23 06:00
PHST- 2009/12/23 06:00 [entrez]
PHST- 2009/12/23 06:00 [pubmed]
PHST- 2010/04/29 06:00 [medline]
AID - 36/1/30 [pii]
AID - 10.1136/jme.2009.031047 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Jan;36(1):30-3. doi: 10.1136/jme.2009.031047.


PMID- 20026688
OWN - NLM
STAT- MEDLINE
DCOM- 20100428
LR  - 20151119
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 1
DP  - 2010 Jan
TI  - When physicians forego the doctor-patient relationship, should they elect to
      self-prescribe or curbside? An empirical and ethical analysis.
PG  - 19-23
LID - 10.1136/jme.2009.032169 [doi]
AB  - BACKGROUND: The American Medical Association, the British Medical Association and
      the Canadian Medical Association have guidelines that specifically discourage
      physicians from self-prescribing or prescribing to family members, but only the
      BMA addresses informal prescription requests between colleagues. OBJECTIVE: To
      examine the practices of paediatric providers regarding self-prescribing,
      curbsiding colleagues, and prescribing and refusing to prescribe to friends and
      family. METHODS: 1086 paediatricians listed from the American Academy of
      Paediatrics 2007 web-based directory were surveyed. RESULTS: 44% (430/982) of
      eligible survey respondents returned usable surveys. Almost half (198/407) of
      respondents had prescribed for themselves. An equal number (198/411) had
      informally requested a prescription from a colleague. Three-quarters (325/429)
      stated they had been asked to prescribe a prescription drug for a first-degree or
      second-degree relative, and 51% (186/363) had been asked by their spouse.
      Eighty-six per cent (343/397) stated that they had refused to write a
      prescription on at least one occasion for a friend or family member. The
      following reasons "strongly influenced" their decision to refuse a prescription
      request: (1) outside of provider's expertise (88%); (2) patient's need for his or
      her own physician (70%); (3) not medically indicated (69%); (4) need for a
      physical examination (65%). CONCLUSION: These data confirm that most physicians
      have engaged in self-prescribing or curbside requests for prescriptions. It can
      be argued that curbsiding is more morally problematic than self-prescribing
      because it implicates a third party, and should be discouraged regardless of
      whether the requester is a colleague, family member or friend.
FAU - Walter, J K
AU  - Walter JK
AD  - University of Chicago, Chicago, IL60637, USA.
FAU - Lang, C W
AU  - Lang CW
FAU - Ross, L F
AU  - Ross LF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Attitude of Health Personnel
MH  - *Drug Prescriptions
MH  - Ethical Analysis
MH  - Humans
MH  - Pediatrics/*ethics
MH  - Physician-Patient Relations
MH  - Refusal to Treat/ethics
MH  - Self Care/*ethics
MH  - Surveys and Questionnaires
MH  - United States
EDAT- 2009/12/23 06:00
MHDA- 2010/04/29 06:00
CRDT- 2009/12/23 06:00
PHST- 2009/12/23 06:00 [entrez]
PHST- 2009/12/23 06:00 [pubmed]
PHST- 2010/04/29 06:00 [medline]
AID - 36/1/19 [pii]
AID - 10.1136/jme.2009.032169 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Jan;36(1):19-23. doi: 10.1136/jme.2009.032169.


PMID- 20026686
OWN - NLM
STAT- MEDLINE
DCOM- 20100428
LR  - 20151119
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 1
DP  - 2010 Jan
TI  - "It's crucial they're treated as patients": ethical guidance and empirical
      evidence regarding treating doctor-patients.
PG  - 7-11
LID - 10.1136/jme.2008.029066 [doi]
AB  - Ethical guidance from the British Medical Association (BMA) about treating
      doctor-patients is compared and contrasted with evidence from a qualitative study
      of general practitioners (GPs) who have been patients. Semistructured interviews 
      were conducted with 17 GPs who had experienced a significant illness. Their
      experiences were discussed and issues about both being and treating
      doctor-patients were revealed. Interpretative phenomenological analysis was used 
      to evaluate the data. In this article data extracts are used to illustrate and
      discuss three key points that summarise the BMA ethical guidance, in order to
      develop a picture of how far experiences map onto guidance. The data illustrate
      and extend the complexities of the issues outlined by the BMA document. In
      particular, differences between experienced GPs and those who have recently
      completed their training are identified. This analysis will be useful for medical
      professionals both when they themselves are unwell and when they treat
      doctor-patients. It will also inform recommendations for professionals who
      educate medical students or trainees.
FAU - Fox, F E
AU  - Fox FE
AD  - Hope House Surgery, Radstock, UK.
FAU - Taylor, G J
AU  - Taylor GJ
FAU - Harris, M F
AU  - Harris MF
FAU - Rodham, K J
AU  - Rodham KJ
FAU - Sutton, J
AU  - Sutton J
FAU - Scott, J
AU  - Scott J
FAU - Robinson, B
AU  - Robinson B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Confidentiality
MH  - Humans
MH  - *Interprofessional Relations/ethics
MH  - Patient Satisfaction
MH  - *Physician-Patient Relations/ethics
MH  - Physicians, Family/*psychology
MH  - Quality of Health Care/ethics/*standards
MH  - Surveys and Questionnaires
EDAT- 2009/12/23 06:00
MHDA- 2010/04/29 06:00
CRDT- 2009/12/23 06:00
PHST- 2009/12/23 06:00 [entrez]
PHST- 2009/12/23 06:00 [pubmed]
PHST- 2010/04/29 06:00 [medline]
AID - 36/1/7 [pii]
AID - 10.1136/jme.2008.029066 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Jan;36(1):7-11. doi: 10.1136/jme.2008.029066.


PMID- 20026685
OWN - NLM
STAT- MEDLINE
DCOM- 20100428
LR  - 20151119
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 36
IP  - 1
DP  - 2010 Jan
TI  - Ascribing intentions in clinical decision-making.
PG  - 2-6
LID - 10.1136/jme.2009.032045 [doi]
AB  - BACKGROUND: The intentions of clinicians are widely considered to be relevant to 
      the ethical assessment of their actions. A better understanding of the
      psychological factors that influence the ascription of intentions in clinical
      practice is important for improving the self-understanding of clinical
      decision-making and, ultimately, the ethics of clinical care. Drawing on
      empirical research on intentionality that has been done in other contexts, this
      is the first study to test whether the "asymmetric effect" of intention
      ascription is exhibited by respondents when presented with clinical
      decision-making scenarios. OBJECTIVE: To assess how individuals attribute
      intentions to clinical actors in clinical decision-making scenarios. METHODS: A
      total of 149 first and second year medical students was randomly assigned to two 
      groups (group A, group B). Subjects in each group read two scenarios and
      submitted anonymous responses to questions regarding each scenario. RESULTS: The 
      asymmetric effect was strongly exhibited by the responses given to scenario 2,
      but it was not exhibited by the responses given to scenario 1. CONCLUSION: The
      present study provided evidence for the view that people's ascription of
      intentions to others is influenced by their previous evaluative judgement of the 
      conduct in question.
FAU - Jansen, L A
AU  - Jansen LA
AD  - The John J Conley Department of Ethics, 153 West 11th Street (NR815), New York,
      NY 10011, USA. Ljansen@svcmcny.org
FAU - Fogel, J S
AU  - Fogel JS
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Adult
MH  - Attitude of Health Personnel
MH  - *Clinical Medicine
MH  - *Decision Making
MH  - Female
MH  - Humans
MH  - *Intention
MH  - Male
MH  - Students, Medical/psychology
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2009/12/23 06:00
MHDA- 2010/04/29 06:00
CRDT- 2009/12/23 06:00
PHST- 2009/12/23 06:00 [entrez]
PHST- 2009/12/23 06:00 [pubmed]
PHST- 2010/04/29 06:00 [medline]
AID - 36/1/2 [pii]
AID - 10.1136/jme.2009.032045 [doi]
PST - ppublish
SO  - J Med Ethics. 2010 Jan;36(1):2-6. doi: 10.1136/jme.2009.032045.


PMID- 20026528
OWN - NLM
STAT- MEDLINE
DCOM- 20100323
LR  - 20100114
IS  - 1744-5019 (Electronic)
IS  - 0360-5310 (Linking)
VI  - 35
IP  - 1
DP  - 2010 Feb
TI  - La frontera: responsibly managing borders and boundaries in clinical ethics.
PG  - 1-6
LID - 10.1093/jmp/jhp057 [doi]
AB  - The papers in the 2010 "Clinical Ethics" number of the Journal of Medicine and
      Philosophy explore issues along La Frontera, the borders and boundaries of
      clinical ethics. The first three papers in this "Clinical Ethics" number of the
      Journal explore borders and boundaries drawn within clinical ethics, concerning
      the moral standing of complementary and alternative medicine, palliative
      sedation, and induced abortion and feticide. The fourth and fifth papers explore 
      the borders and boundaries between research ethics and clinical ethics.
FAU - McCullough, Laurence B
AU  - McCullough LB
AD  - Dalton Tomlin Chair in Medical Ethics and Health Policy, Center for Medical
      Ethics and Health Policy, Baylor College of Medicine, One Baylor Plaza MS 420,
      Houston, TX 77030-3411, USA. mccullou@bcm.tmc.edu
LA  - eng
PT  - Introductory Journal Article
DEP - 20091221
PL  - United States
TA  - J Med Philos
JT  - The Journal of medicine and philosophy
JID - 7610512
SB  - IM
MH  - Abortion, Induced/ethics
MH  - Complementary Therapies/ethics
MH  - Disabled Persons
MH  - *Ethics, Medical
MH  - Ethics, Research
MH  - Hippocratic Oath
MH  - Humans
MH  - Interprofessional Relations/ethics
MH  - Morals
MH  - Palliative Care/ethics
MH  - *Philosophy, Medical
MH  - Physician-Patient Relations/ethics
EDAT- 2009/12/23 06:00
MHDA- 2010/03/24 06:00
CRDT- 2009/12/23 06:00
PHST- 2009/12/23 06:00 [entrez]
PHST- 2009/12/23 06:00 [pubmed]
PHST- 2010/03/24 06:00 [medline]
AID - jhp057 [pii]
AID - 10.1093/jmp/jhp057 [doi]
PST - ppublish
SO  - J Med Philos. 2010 Feb;35(1):1-6. doi: 10.1093/jmp/jhp057. Epub 2009 Dec 21.


PMID- 20026526
OWN - NLM
STAT- MEDLINE
DCOM- 20100323
LR  - 20100114
IS  - 1744-5019 (Electronic)
IS  - 0360-5310 (Linking)
VI  - 35
IP  - 1
DP  - 2010 Feb
TI  - The exceptional ethics of the investigator-subject relationship.
PG  - 64-80
LID - 10.1093/jmp/jhp055 [doi]
AB  - This article concerns the validity of six canonical rules that institutional
      review boards use to constrain the behavior of investigators. These rules require
      investigators to design their studies in a scientifically valid way, not pay
      their subjects to take risks, minimize risks to their subjects, secure for their 
      subjects access to effective interventions post-trial, not pay their subjects too
      much and allow their subjects to withdraw from the study unconditionally.
      Enforcement of these rules is problematic because there are other relationships
      that seem to be like the investigator-subject relationship in all ethically
      relevant respects, such as the employer-employee and volunteer
      organizer-volunteer relationships, to which we would not dream of applying these 
      same rules. Applying these rules in one context but not the others is a violation
      of ethical consistency I label "exceptionalism." We should conclude that it is
      time to reexamine the validity of the six rules.
FAU - Sachs, Benjamin
AU  - Sachs B
AD  - Program in Environmental Studies and Center for Bioethics, New York University,
      285 Mercer Street 9th Floor, New York, NY 10012, USA. sachs@nyu.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091221
PL  - United States
TA  - J Med Philos
JT  - The Journal of medicine and philosophy
JID - 7610512
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Ethical Analysis
MH  - Humans
MH  - Patient Dropouts
MH  - Philosophy, Medical
MH  - *Professional-Patient Relations
MH  - Research Design
MH  - Research Personnel/*ethics
MH  - *Research Subjects
MH  - Risk Reduction Behavior
EDAT- 2009/12/23 06:00
MHDA- 2010/03/24 06:00
CRDT- 2009/12/23 06:00
PHST- 2009/12/23 06:00 [entrez]
PHST- 2009/12/23 06:00 [pubmed]
PHST- 2010/03/24 06:00 [medline]
AID - jhp055 [pii]
AID - 10.1093/jmp/jhp055 [doi]
PST - ppublish
SO  - J Med Philos. 2010 Feb;35(1):64-80. doi: 10.1093/jmp/jhp055. Epub 2009 Dec 21.


PMID- 20025805
OWN - NLM
STAT- MEDLINE
DCOM- 20100210
LR  - 20091222
IS  - 1469-2147 (Electronic)
IS  - 0963-1801 (Linking)
VI  - 19
IP  - 1
DP  - 2010 Winter
TI  - Choosing deafness with preimplantation genetic diagnosis: an ethical way to carry
      on a cultural bloodline?
PG  - 86-96
LID - 10.1017/S0963180109990272 [doi]
FAU - Camporesi, Silvia
AU  - Camporesi S
AD  - European School of Molecular Medicine, in collaboration with the University of
      Milan, Italy.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Camb Q Healthc Ethics
JT  - Cambridge quarterly of healthcare ethics : CQ : the international journal of
      healthcare ethics committees
JID - 9208482
SB  - IM
MH  - Canada
MH  - Choice Behavior/*ethics
MH  - Deafness/*diagnosis/*genetics
MH  - *Disabled Persons
MH  - Europe
MH  - Female
MH  - Humans
MH  - Morals
MH  - *Parents/education
MH  - Pregnancy
MH  - *Preimplantation Diagnosis/ethics
MH  - United States
EDAT- 2009/12/23 06:00
MHDA- 2010/02/11 06:00
CRDT- 2009/12/23 06:00
PHST- 2009/12/23 06:00 [entrez]
PHST- 2009/12/23 06:00 [pubmed]
PHST- 2010/02/11 06:00 [medline]
AID - S0963180109990272 [pii]
AID - 10.1017/S0963180109990272 [doi]
PST - ppublish
SO  - Camb Q Healthc Ethics. 2010 Winter;19(1):86-96. doi: 10.1017/S0963180109990272.


PMID- 20025804
OWN - NLM
STAT- MEDLINE
DCOM- 20100210
LR  - 20091222
IS  - 1469-2147 (Electronic)
IS  - 0963-1801 (Linking)
VI  - 19
IP  - 1
DP  - 2010 Winter
TI  - The ethics of aggressive discharge planning.
PG  - 75-85
LID - 10.1017/S0963180109990260 [doi]
FAU - Browne, Alister
AU  - Browne A
AD  - Faculty of Medicine, University of British Columbia.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Camb Q Healthc Ethics
JT  - Cambridge quarterly of healthcare ethics : CQ : the international journal of
      healthcare ethics committees
JID - 9208482
SB  - IM
MH  - Canada
MH  - Cost-Benefit Analysis
MH  - Decision Making
MH  - Ethical Analysis
MH  - Ethical Theory
MH  - Health Care Rationing/*ethics
MH  - Health Policy
MH  - Humans
MH  - Morbidity
MH  - Mortality
MH  - *Patient Discharge/standards
EDAT- 2009/12/23 06:00
MHDA- 2010/02/11 06:00
CRDT- 2009/12/23 06:00
PHST- 2009/12/23 06:00 [entrez]
PHST- 2009/12/23 06:00 [pubmed]
PHST- 2010/02/11 06:00 [medline]
AID - S0963180109990260 [pii]
AID - 10.1017/S0963180109990260 [doi]
PST - ppublish
SO  - Camb Q Healthc Ethics. 2010 Winter;19(1):75-85. doi: 10.1017/S0963180109990260.


PMID- 20025803
OWN - NLM
STAT- MEDLINE
DCOM- 20100210
LR  - 20211020
IS  - 1469-2147 (Electronic)
IS  - 0963-1801 (Linking)
VI  - 19
IP  - 1
DP  - 2010 Winter
TI  - Consequentialism without consequences: ethics and embryo research.
PG  - 61-74
LID - 10.1017/S0963180109990259 [doi]
FAU - Chan, Sarah
AU  - Chan S
AD  - Institute for Science, Ethics and Innovation, University of Manchester.
FAU - Harris, John
AU  - Harris J
LA  - eng
GR  - 087439/WT_/Wellcome Trust/United Kingdom
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Camb Q Healthc Ethics
JT  - Cambridge quarterly of healthcare ethics : CQ : the international journal of
      healthcare ethics committees
JID - 9208482
SB  - IM
CON - Camb Q Healthc Ethics. 2010 Winter;19(1):51-60. PMID: 20025802
MH  - Embryo Research/*ethics
MH  - Embryo, Mammalian
MH  - *Embryonic Stem Cells
MH  - Ethical Analysis
MH  - *Ethical Theory
MH  - Goals
MH  - Humans
MH  - *Life
MH  - *Reproduction/ethics
PMC - PMC4829096
MID - EMS50859
OID - NLM: EMS50859
EDAT- 2009/12/23 06:00
MHDA- 2010/02/11 06:00
CRDT- 2009/12/23 06:00
PHST- 2009/12/23 06:00 [entrez]
PHST- 2009/12/23 06:00 [pubmed]
PHST- 2010/02/11 06:00 [medline]
AID - S0963180109990259 [pii]
AID - 10.1017/S0963180109990259 [doi]
PST - ppublish
SO  - Camb Q Healthc Ethics. 2010 Winter;19(1):61-74. doi: 10.1017/S0963180109990259.


PMID- 20024625
OWN - NLM
STAT- MEDLINE
DCOM- 20100621
LR  - 20211020
IS  - 1572-8633 (Electronic)
IS  - 1386-7423 (Linking)
VI  - 13
IP  - 2
DP  - 2010 May
TI  - End-of-life ethics and disability: differing perspectives on case-based teaching.
PG  - 115-26
LID - 10.1007/s11019-009-9231-x [doi]
AB  - The way in which medical professionals engage in bioethical issues ultimately
      reflects the type of care such patients are likely to receive. It is therefore
      critical for doctors and other health care professionals to have a broad
      understanding of disability. Our purpose in this paper is to explore ways of
      teaching bioethical issues to first year medical students by integrating
      alternative approaches. Such approaches include (a) the use of the narrative
      format, (b) the inclusion of a disability perspective, and (c) the presentation
      and facilitation of classes by people with disabilities. We consider how these
      new kinds of presentations are evaluated by students, faculty, people with
      disabilities and professional ethicists. We hope new knowledge may provide health
      care professionals with a greater understanding of the perspectives of patients
      with disabilities, who are confronted by conflicting ethical values and
      frameworks for decision-making in their interaction with such professionals.
FAU - Kaufert, Joseph
AU  - Kaufert J
AD  - Department of Community Health Sciences, Faculty of Medicine, University of
      Manitoba, 750 Bannatyne Ave., Winnipeg, MB, R3E OW3, Canada.
      joseph_kaufert@umanitoba.ca
FAU - Wiebe, Rhonda
AU  - Wiebe R
FAU - Schwartz, Karen
AU  - Schwartz K
FAU - Labine, Lisa
AU  - Labine L
FAU - Lutfiyya, Zana Marie
AU  - Lutfiyya ZM
FAU - Pearse, Catherine
AU  - Pearse C
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Med Health Care Philos
JT  - Medicine, health care, and philosophy
JID - 9815900
SB  - IM
MH  - Curriculum
MH  - Decision Making
MH  - *Disabled Persons
MH  - Education, Medical/*organization & administration
MH  - Ethics, Medical/*education
MH  - Humans
MH  - Terminal Care/*ethics
EDAT- 2009/12/22 06:00
MHDA- 2010/06/22 06:00
CRDT- 2009/12/22 06:00
PHST- 2009/12/22 06:00 [entrez]
PHST- 2009/12/22 06:00 [pubmed]
PHST- 2010/06/22 06:00 [medline]
AID - 10.1007/s11019-009-9231-x [doi]
PST - ppublish
SO  - Med Health Care Philos. 2010 May;13(2):115-26. doi: 10.1007/s11019-009-9231-x.


PMID- 20023708
OWN - NLM
STAT- MEDLINE
DCOM- 20110301
LR  - 20100811
IS  - 1476-5365 (Electronic)
IS  - 0268-3369 (Linking)
VI  - 45
IP  - 8
DP  - 2010 Aug
TI  - Family donor care management: principles and recommendations.
PG  - 1269-73
LID - 10.1038/bmt.2009.354 [doi]
AB  - The World Marrow Donor Association (WMDA) is an international organization
      fostering collaboration in clinical transplantation and promoting the interests
      of unrelated stem cell donors. The WMDA has developed standards for the
      recruitment, counseling, work-up and subsequent donations to protect the
      interests of donors. Although the care of family donors has been carefully
      considered and managed in transplant centers (TCs) internationally over numerous 
      years (and increasingly TCs are facing accreditation programs, which address this
      issue) there is currently a lack of standardized guidelines for the management of
      family donors. The underlying principles of family donor care are in many ways
      identical to those concerning unrelated donors, although key ethical
      considerations differ. Although the WMDA is primarily involved in the field of
      unrelated donors, we believe that it is important to collaborate with those
      involved with family donors, to standardize the care. This document hopes to
      encourage increased collaboration between those caring for related and unrelated 
      donors, and build on the extensive work, which has already been undertaken in
      this field to homogenize care. We recognize that there will be financial,
      regulatory and logistic differences in different countries and that the manner in
      which these principles are achieved may vary.
FAU - van Walraven, S M
AU  - van Walraven SM
AD  - Department of Pediatric Stem Cell Transplantation, Leiden University Medical
      Centre, Leiden, The Netherlands. s.m.van_walraven@lumc.nl
FAU - Nicoloso-de Faveri, G
AU  - Nicoloso-de Faveri G
FAU - Axdorph-Nygell, U A I
AU  - Axdorph-Nygell UA
FAU - Douglas, K W
AU  - Douglas KW
FAU - Jones, D A
AU  - Jones DA
FAU - Lee, S J
AU  - Lee SJ
FAU - Pulsipher, M
AU  - Pulsipher M
FAU - Ritchie, L
AU  - Ritchie L
FAU - Halter, J
AU  - Halter J
FAU - Shaw, B E
AU  - Shaw BE
CN  - WMDA Ethics and Clinical working groups
LA  - eng
PT  - Journal Article
DEP - 20091221
PL  - England
TA  - Bone Marrow Transplant
JT  - Bone marrow transplantation
JID - 8702459
SB  - IM
MH  - Bone Marrow Transplantation/standards
MH  - Family
MH  - Hematopoietic Stem Cell Transplantation/*standards
MH  - Humans
MH  - *International Agencies
MH  - International Cooperation
MH  - *Living Donors
MH  - Practice Guidelines as Topic/standards
EDAT- 2009/12/22 06:00
MHDA- 2011/03/02 06:00
CRDT- 2009/12/22 06:00
PHST- 2009/12/22 06:00 [entrez]
PHST- 2009/12/22 06:00 [pubmed]
PHST- 2011/03/02 06:00 [medline]
AID - bmt2009354 [pii]
AID - 10.1038/bmt.2009.354 [doi]
PST - ppublish
SO  - Bone Marrow Transplant. 2010 Aug;45(8):1269-73. doi: 10.1038/bmt.2009.354. Epub
      2009 Dec 21.


PMID- 20022543
OWN - NLM
STAT- MEDLINE
DCOM- 20100420
LR  - 20100427
IS  - 1769-6682 (Electronic)
IS  - 1297-9589 (Linking)
VI  - 38
IP  - 1
DP  - 2010 Jan
TI  - [Egg donation: regulation of the donation and the hidden face of the cross-border
      reproductive care].
PG  - 36-44
LID - 10.1016/j.gyobfe.2009.11.008 [doi]
AB  - In France egg donation is not sufficient to meet the needs of infertile couples. 
      As a consequence there is a long waiting time for those couples who may be driven
      to search solutions abroad. Nonetheless in some countries practice of egg
      donation raises medical and ethical questions regarding the quality of care
      provided to the recipients as well as the recruitment and follow-up of egg
      donors. Meanwhile the scope of this type of "cross-border reproductive care"
      remains difficult to assess, even though this trend seems to be growing and is
      reinforced by a recent regulation facilitating the free movement of people
      seeking cross-border health care within the European Union. These observations
      lead to question the possible causes of "cross-border reproductive care" in the
      light of national laws, to identify potential consequences in order to suggest
      possible actions at both national and international level.
CI  - Copyright 2009 Elsevier Masson SAS. All rights reserved.
FAU - Merlet, F
AU  - Merlet F
AD  - Direction medicale et scientifique, Agence de la biomedecine, Saint-Denis La
      Plaine, France. francoise.merlet@biomedecine.fr
FAU - Senemaud, B
AU  - Senemaud B
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Prise en charge du don d'ovocytes: reglementation du don, la face cachee du
      tourisme procreatif.
DEP - 20091221
PL  - France
TA  - Gynecol Obstet Fertil
JT  - Gynecologie, obstetrique & fertilite
JID - 100936305
SB  - IM
CIN - Gynecol Obstet Fertil. 2010 Apr;38(4):300. PMID: 20362482
MH  - Delivery of Health Care/ethics/*legislation & jurisprudence
MH  - Embryo Disposition/ethics/legislation & jurisprudence
MH  - European Union
MH  - Female
MH  - Humans
MH  - National Health Programs/ethics/legislation & jurisprudence
MH  - Oocyte Donation/ethics/*legislation & jurisprudence
RF  - 18
EDAT- 2009/12/22 06:00
MHDA- 2010/04/21 06:00
CRDT- 2009/12/22 06:00
PHST- 2009/09/15 00:00 [received]
PHST- 2009/10/26 00:00 [accepted]
PHST- 2009/12/22 06:00 [entrez]
PHST- 2009/12/22 06:00 [pubmed]
PHST- 2010/04/21 06:00 [medline]
AID - S1297-9589(09)00419-6 [pii]
AID - 10.1016/j.gyobfe.2009.11.008 [doi]
PST - ppublish
SO  - Gynecol Obstet Fertil. 2010 Jan;38(1):36-44. doi: 10.1016/j.gyobfe.2009.11.008.
      Epub 2009 Dec 21.


PMID- 20022143
OWN - NLM
STAT- MEDLINE
DCOM- 20100824
LR  - 20161020
IS  - 1578-1283 (Electronic)
IS  - 0213-9111 (Linking)
VI  - 24
IP  - 2
DP  - 2010 Mar-Apr
TI  - [On the reliability of information sources and the ethics of their use].
PG  - 178; discussion 178-9
LID - 10.1016/j.gaceta.2009.10.010 [doi]
FAU - Gispert, Rosa
AU  - Gispert R
FAU - Bosser, Roser
AU  - Bosser R
LA  - spa
PT  - Letter
TT  - Sobre la solvencia de las fuentes de informacion y la etica en su utilizacion.
PL  - Spain
TA  - Gac Sanit
JT  - Gaceta sanitaria
JID - 8901623
SB  - IM
MH  - Abortion, Induced/*statistics & numerical data
MH  - Humans
MH  - Information Services/*ethics/*standards
MH  - Reproducibility of Results
MH  - Spain
EDAT- 2009/12/22 06:00
MHDA- 2010/08/25 06:00
CRDT- 2009/12/22 06:00
PHST- 2009/10/02 00:00 [received]
PHST- 2009/10/07 00:00 [accepted]
PHST- 2009/12/22 06:00 [entrez]
PHST- 2009/12/22 06:00 [pubmed]
PHST- 2010/08/25 06:00 [medline]
AID - S0213-9111(09)00375-6 [pii]
AID - 10.1016/j.gaceta.2009.10.010 [doi]
PST - ppublish
SO  - Gac Sanit. 2010 Mar-Apr;24(2):178; discussion 178-9. doi:
      10.1016/j.gaceta.2009.10.010.


PMID- 20020443
OWN - NLM
STAT- MEDLINE
DCOM- 20100119
LR  - 20100104
IS  - 1097-4652 (Electronic)
IS  - 0021-9541 (Linking)
VI  - 222
IP  - 3
DP  - 2010 Mar
TI  - Are induced pluripotent stem cells the future of cell-based regenerative
      therapies for spinal cord injury?
PG  - 515-21
LID - 10.1002/jcp.21995 [doi]
AB  - Despite advances in medical and surgical care, current clinical therapies for
      spinal cord injury (SCI) are limited. During the last two decades, the search for
      new therapies has been revolutionized by the discovery of stem cells, inspiring
      scientists and clinicians to search for stem cell-based reparative approaches for
      many disorders, including neurotrauma. Cell-based therapies using embryonic and
      adult stem cells in animal models of these disorders have provided positive
      outcome results. However, the availability of clinically suitable cell sources
      for human application has been hindered by both technical and ethical issues. The
      recent discovery of induced pluripotent stem (iPS) cells holds the potential to
      revolutionize the field of regenerative medicine by offering the option of
      autologous transplantation, thus eliminating the issue of host rejection. Herein,
      we will provide the rationale for the use of iPS cells in SCI therapies. In this 
      review, we will evaluate the recent advancements in the field of iPS cells
      including their capacity for differentiation toward neural lineages that may
      allow iPS cells transplantation in cell-based therapy for spinal cord repair.
FAU - Salewski, Ryan P F
AU  - Salewski RP
AD  - Division of Genetics and Development, Toronto Western Research Institute,
      Toronto, Ontario M5T 2S8, Canada.
FAU - Eftekharpour, Eftekhar
AU  - Eftekharpour E
FAU - Fehlings, Michael G
AU  - Fehlings MG
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Cell Physiol
JT  - Journal of cellular physiology
JID - 0050222
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Cell Differentiation
MH  - Cell Lineage
MH  - Cell Survival
MH  - Humans
MH  - Neurons/metabolism/*transplantation
MH  - Pluripotent Stem Cells/metabolism/*transplantation
MH  - *Regeneration
MH  - *Regenerative Medicine
MH  - Spinal Cord Injuries/physiopathology/*surgery
MH  - Transcription Factors/genetics/metabolism
MH  - Transplantation, Autologous
RF  - 77
EDAT- 2009/12/19 06:00
MHDA- 2010/01/20 06:00
CRDT- 2009/12/19 06:00
PHST- 2009/12/19 06:00 [entrez]
PHST- 2009/12/19 06:00 [pubmed]
PHST- 2010/01/20 06:00 [medline]
AID - 10.1002/jcp.21995 [doi]
PST - ppublish
SO  - J Cell Physiol. 2010 Mar;222(3):515-21. doi: 10.1002/jcp.21995.


PMID- 20019298
OWN - NLM
STAT- MEDLINE
DCOM- 20100202
LR  - 20211020
IS  - 1541-0048 (Electronic)
IS  - 0090-0036 (Linking)
VI  - 100
IP  - 2
DP  - 2010 Feb
TI  - Ancillary care in community-based public health intervention research.
PG  - 211-6
LID - 10.2105/AJPH.2009.168393 [doi]
AB  - Community-based public health intervention research in developing countries
      typically takes place not in clinics but in people's homes and other living
      spaces. Research subjects and their communities may lack adequate nutrition,
      clean water, sanitation, and basic preventive and therapeutic services.
      Researchers often encounter unmet health needs in their interactions with
      individual subjects and need ethical guidelines to help them decide how to
      respond. To what extent do researchers have an ethical obligation to provide
      ancillary care-health care beyond what is necessary to ensure scientific validity
      and subjects' safety? We discuss a case example from Nepal and propose a simple
      2-step sequence of questions to aid decision making.
FAU - Merritt, Maria W
AU  - Merritt MW
AD  - Berman Institute of Bioethics, Johns Hopkins University, 615 N Wolfe St, Suite
      E8132, Baltimore MD 21205, USA. mmerritt@jhsph.edu
FAU - Taylor, Holly A
AU  - Taylor HA
FAU - Mullany, Luke C
AU  - Mullany LC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091217
PL  - United States
TA  - Am J Public Health
JT  - American journal of public health
JID - 1254074
SB  - IM
MH  - Community-Based Participatory Research/*ethics
MH  - Decision Making/*ethics
MH  - Developing Countries
MH  - *Health Services Needs and Demand
MH  - Humans
MH  - Infant Care
MH  - Infant, Newborn
MH  - *Moral Obligations
MH  - Nepal
MH  - *Preventive Health Services
PMC - PMC2804641
EDAT- 2009/12/19 06:00
MHDA- 2010/02/03 06:00
CRDT- 2009/12/19 06:00
PHST- 2009/12/19 06:00 [entrez]
PHST- 2009/12/19 06:00 [pubmed]
PHST- 2010/02/03 06:00 [medline]
AID - AJPH.2009.168393 [pii]
AID - 10.2105/AJPH.2009.168393 [doi]
PST - ppublish
SO  - Am J Public Health. 2010 Feb;100(2):211-6. doi: 10.2105/AJPH.2009.168393. Epub
      2009 Dec 17.


PMID- 20019296
OWN - NLM
STAT- MEDLINE
DCOM- 20100202
LR  - 20211020
IS  - 1541-0048 (Electronic)
IS  - 0090-0036 (Linking)
VI  - 100
IP  - 2
DP  - 2010 Feb
TI  - Ethics-based public health policy?
PG  - 197-8
LID - 10.2105/AJPH.2009.181511 [doi]
FAU - Petrini, Carlo
AU  - Petrini C
LA  - eng
PT  - Comment
PT  - Letter
DEP - 20091217
PL  - United States
TA  - Am J Public Health
JT  - American journal of public health
JID - 1254074
SB  - IM
CON - Am J Public Health. 2009 Sep;99(9):1576-83. PMID: 19608941
MH  - *Ethical Analysis
MH  - *Health Policy
MH  - Humans
MH  - Public Health/*ethics
PMC - PMC2804644
EDAT- 2009/12/19 06:00
MHDA- 2010/02/03 06:00
CRDT- 2009/12/19 06:00
PHST- 2009/12/19 06:00 [entrez]
PHST- 2009/12/19 06:00 [pubmed]
PHST- 2010/02/03 06:00 [medline]
AID - AJPH.2009.181511 [pii]
AID - 10.2105/AJPH.2009.181511 [doi]
PST - ppublish
SO  - Am J Public Health. 2010 Feb;100(2):197-8. doi: 10.2105/AJPH.2009.181511. Epub
      2009 Dec 17.


PMID- 20019235
OWN - NLM
STAT- MEDLINE
DCOM- 20100105
LR  - 20171114
IS  - 1468-330X (Electronic)
IS  - 0022-3050 (Linking)
VI  - 81
IP  - 1
DP  - 2010 Jan
TI  - CSF biomarker utilisation and ethical considerations of biomarker assisted
      diagnosis and research in dementia: perspectives from within the European
      Alzheimer's Disease Consortium (EADC).
PG  - 124-5
LID - 10.1136/jnnp.2009.176412 [doi]
FAU - Slats, D
AU  - Slats D
FAU - Spies, P E
AU  - Spies PE
FAU - Sjogren, M J C
AU  - Sjogren MJ
FAU - Visser, P-J
AU  - Visser PJ
FAU - Verbeek, M M
AU  - Verbeek MM
FAU - Rikkert, M G M Olde
AU  - Rikkert MG
FAU - Kehoe, P G
AU  - Kehoe PG
LA  - eng
PT  - Letter
PL  - England
TA  - J Neurol Neurosurg Psychiatry
JT  - Journal of neurology, neurosurgery, and psychiatry
JID - 2985191R
RN  - 0 (Biomarkers)
SB  - IM
MH  - Biomarkers/*cerebrospinal fluid
MH  - Biomedical Research
MH  - Data Collection
MH  - Dementia/*cerebrospinal fluid/diagnosis
MH  - *Ethics, Medical
MH  - Europe
MH  - Humans
MH  - Societies, Medical
EDAT- 2009/12/19 06:00
MHDA- 2010/01/06 06:00
CRDT- 2009/12/19 06:00
PHST- 2009/12/19 06:00 [entrez]
PHST- 2009/12/19 06:00 [pubmed]
PHST- 2010/01/06 06:00 [medline]
AID - 81/1/124 [pii]
AID - 10.1136/jnnp.2009.176412 [doi]
PST - ppublish
SO  - J Neurol Neurosurg Psychiatry. 2010 Jan;81(1):124-5. doi:
      10.1136/jnnp.2009.176412.


PMID- 20019142
OWN - NLM
STAT- MEDLINE
DCOM- 20100126
LR  - 20220331
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 254
IP  - 1
DP  - 2010 Jan
TI  - Evolution of radiation-induced brain injury: MR imaging-based study.
PG  - 210-8
LID - 10.1148/radiol.09090428 [doi]
AB  - PURPOSE: To evaluate the temporal lobes in patients previously treated for
      nasopharyngeal carcinoma to provide a better understanding of delayed
      radiation-induced injury in the brain unaffected by the underlying tumor.
      MATERIALS AND METHODS: Retrospective analysis of the patient data was approved by
      the local ethics committee. Informed consent was waived. Magnetic resonance (MR) 
      imaging results in patients with temporal lobe injury (TLI) after receiving
      radiation for nasopharyngeal carcinoma were analyzed. The appearance and change
      over time of white matter lesions (WMLs), contrast material-enhanced lesions, and
      cysts were assessed. The Mann-Whitney U test was used to compare interval time,
      and the chi(2) and Fisher exact tests were used to compare the pattern of TLI
      changes. RESULTS: The study group was 124 patients (95 men, 29 women; mean age,
      51.4 years) with 192 injured temporal lobes; 62 of these patients with 103
      injured temporal lobes underwent follow-up MR imaging at least once (range, one
      to five examinations). A total of 332 injured temporal lobes were revealed. WMLs,
      contrast-enhanced lesions, and cysts were present on 332 (100%), 274 (82.5%), and
      42 (12.7%) studies, respectively. All contrast-enhanced lesions more than 2 cm in
      size showed necrosis, and those 3 cm or greater formed a rim-enhanced necrotic
      mass. WMLs were the only lesion to occur alone, contrast-enhanced lesions were
      always accompanied by WMLs, and cysts were always accompanied by WMLs and
      contrast-enhanced lesions. Detection of cysts was significantly later than
      detection of WMLs and contrast-enhanced lesions (P <.01). Regression or
      resolution was found in 27 (28%) of 96 WMLs, 37 (39%) of 94 contrast-enhanced
      lesions, and one (7%) of 15 cysts. CONCLUSION: TLI from radiation is not always
      an irreversible and progressive process but is one that can regress or resolve at
      MR imaging. In the evolution of radiation injury, WMLs are seen first and are
      followed by contrast-enhanced lesions, which have an increasing tendency to
      become necrotic with increasing size. Cysts are the least frequent manifestation 
      and arise in the late stage of TLI.
FAU - Wang, Yi-Xiang J
AU  - Wang YX
AD  - Department of Diagnostic Radiology, Chinese University of Hong Kong, Prince of
      Wales Hospital, Shatin, Hong Kong, People's Republic of China.
FAU - King, Ann D
AU  - King AD
FAU - Zhou, Hua
AU  - Zhou H
FAU - Leung, Sing-Fei
AU  - Leung SF
FAU - Abrigo, Jill
AU  - Abrigo J
FAU - Chan, Yu-Leung
AU  - Chan YL
FAU - Hu, Chen-Wen
AU  - Hu CW
FAU - Yeung, David K W
AU  - Yeung DK
FAU - Ahuja, Anil T
AU  - Ahuja AT
LA  - eng
PT  - Journal Article
DEP - 20091217
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Chi-Square Distribution
MH  - Contrast Media
MH  - Female
MH  - Gadolinium
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Nasopharyngeal Neoplasms/radiotherapy
MH  - Radiation Injuries/*diagnosis
MH  - Retrospective Studies
MH  - Statistics, Nonparametric
MH  - Temporal Lobe/*radiation effects
EDAT- 2009/12/19 06:00
MHDA- 2010/01/27 06:00
CRDT- 2009/12/19 06:00
PHST- 2009/12/19 06:00 [entrez]
PHST- 2009/12/19 06:00 [pubmed]
PHST- 2010/01/27 06:00 [medline]
AID - radiol.09090428 [pii]
AID - 10.1148/radiol.09090428 [doi]
PST - ppublish
SO  - Radiology. 2010 Jan;254(1):210-8. doi: 10.1148/radiol.09090428. Epub 2009 Dec 17.


PMID- 20019132
OWN - NLM
STAT- MEDLINE
DCOM- 20100126
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 254
IP  - 1
DP  - 2010 Jan
TI  - Crush thoracic trauma in the massive Sichuan earthquake: evaluation with
      multidetector CT of 215 cases.
PG  - 285-91
LID - 10.1148/radiol.09090685 [doi]
AB  - PURPOSE: To determine the multidetector computed tomographic (CT) features of
      crush thoracic traumas resulting from the massive Sichuan earthquake. MATERIALS
      AND METHODS: This study was approved by the ethics committee of the medical
      school, and informed consent was waived. A retrospective review was undertaken of
      215 multidetector chest CT scans of 112 male and 103 female patients who
      sustained crush thoracic injuries in the Sichuan earthquake at 2:28 pm Beijing
      time, May 12, 2008, and were rescued in the authors' hospital. Multidetector
      chest CT studies were performed between May 12, 2008, and June 7, 2008. The
      authors looked for injuries to the thoracic cage, pulmonary parenchyma, and
      pleura. RESULTS: One hundred forty-three patients (66.5%; 95% confidence interval
      [CI]: 60.2%, 72.8%) had at least one rib fracture; the mean number of rib
      fractures per patient was 6 [corrected]. Forty-five of these patients (31.5% of
      143 patients; 95% CI: 23.9%, 39.1%) had flail chest, with a total of 288 ribs
      fractured. There were 46 patients (21.4%; 95% CI: 15.9%, 26.9%) with at least one
      vertebral fracture. There were 77 vertebral fractures total; 36 of these
      fractures were in T1 through T10. Twelve patients (5.6%; 95% CI: 2.5%, 8.7%) had 
      sternal fractures, and 48 patients (22.3%; 95% CI: 16.7%, 27.9%) had either
      scapular or clavicular fractures. There were 117 patients (54.4%; 95% CI: 47.7%, 
      61.1%) with pulmonary parenchymal injuries and 146 (67.9%; 95% CI: 61.7%, 74.1%) 
      with pleural injuries. CONCLUSION: Crush thoracic trauma resulting from the
      massive Sichuan earthquake was a life-threatening injury; this type of injury has
      the potential for multiple fractures and pulmonary parenchymal injuries.
FAU - Dong, Zhi-Hui
AU  - Dong ZH
AD  - Department of Radiology, West China Hospital of Sichuan University, 37 Guo Xue
      Xiang, Chengdu, Sichuan 610041, China.
FAU - Yang, Zhi-Gang
AU  - Yang ZG
FAU - Chen, Tian-Wu
AU  - Chen TW
FAU - Feng, Yuan-Chun
AU  - Feng YC
FAU - Chu, Zhi-Gang
AU  - Chu ZG
FAU - Yu, Jian-Qun
AU  - Yu JQ
FAU - Bai, Hong-Li
AU  - Bai HL
FAU - Wang, Qi-Ling
AU  - Wang QL
LA  - eng
PT  - Journal Article
DEP - 20091217
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
EIN - Radiology. 2010 Apr;255(1):308
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Chi-Square Distribution
MH  - Child
MH  - Child, Preschool
MH  - China/epidemiology
MH  - Crush Syndrome/*diagnostic imaging/epidemiology
MH  - *Earthquakes
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Infant
MH  - Male
MH  - Middle Aged
MH  - Radiographic Image Interpretation, Computer-Assisted
MH  - Retrospective Studies
MH  - Thoracic Injuries/*diagnostic imaging/epidemiology
MH  - Tomography, X-Ray Computed
EDAT- 2009/12/19 06:00
MHDA- 2010/01/27 06:00
CRDT- 2009/12/19 06:00
PHST- 2009/12/19 06:00 [entrez]
PHST- 2009/12/19 06:00 [pubmed]
PHST- 2010/01/27 06:00 [medline]
AID - radiol.09090685 [pii]
AID - 10.1148/radiol.09090685 [doi]
PST - ppublish
SO  - Radiology. 2010 Jan;254(1):285-91. doi: 10.1148/radiol.09090685. Epub 2009 Dec
      17.


PMID- 20018495
OWN - NLM
STAT- MEDLINE
DCOM- 20100430
LR  - 20100203
IS  - 1769-664X (Electronic)
IS  - 0929-693X (Linking)
VI  - 17
IP  - 2
DP  - 2010 Feb
TI  - [Healthcare of imprisoned juveniles: new regulations].
PG  - 166-74
LID - 10.1016/j.arcped.2009.11.013 [doi]
AB  - Several new French regulations have come into effect to regulate the healthcare
      of juvenile offenders in prison with the creation of French Young Offender
      Institutions. They complete the French prison healthcare methodological guide.
      This article presents the new developments in the healthcare of juveniles in
      prison. It specifies the limitations placed on the healthcare team's
      interventions on imprisoned juveniles. Promoting an individualized prisoner
      program, as is done in the school context, outlining parental involvement in this
      program, and withdrawing from the healthcare methodological guide the tasks that 
      are not within the realm of the physician caring for the minor would be measures 
      to ensure good ethical medical practices in prison. These could be applied to
      French secure training centers and secure children's homes.
CI  - Copyright 2009 Elsevier Masson SAS. All rights reserved.
FAU - Sannier, O
AU  - Sannier O
AD  - Unite de consultations et de soins ambulatoires, centre penitentiaire de
      Liancourt, 60140 Liancourt, France. olivier.sannier@ch-creil.fr
FAU - Nappez, S
AU  - Nappez S
FAU - Manaouil, C
AU  - Manaouil C
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Prise en charge sanitaire des mineurs detenus.
DEP - 20091216
PL  - France
TA  - Arch Pediatr
JT  - Archives de pediatrie : organe officiel de la Societe francaise de pediatrie
JID - 9421356
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Chronic Disease
MH  - Cooperative Behavior
MH  - Delivery of Health Care/ethics/*legislation & jurisprudence
MH  - Emergencies
MH  - Ethics, Medical
MH  - France
MH  - Hospitalization/legislation & jurisprudence
MH  - Humans
MH  - Interdisciplinary Communication
MH  - Juvenile Delinquency/ethics/*legislation & jurisprudence
MH  - Parental Consent/ethics/legislation & jurisprudence
MH  - Patient Care Team/ethics/legislation & jurisprudence
MH  - Patient Discharge/legislation & jurisprudence
MH  - Prisoners/*legislation & jurisprudence
MH  - Referral and Consultation/ethics/legislation & jurisprudence
EDAT- 2009/12/19 06:00
MHDA- 2010/05/01 06:00
CRDT- 2009/12/19 06:00
PHST- 2009/04/15 00:00 [received]
PHST- 2009/06/11 00:00 [revised]
PHST- 2009/11/06 00:00 [accepted]
PHST- 2009/12/19 06:00 [entrez]
PHST- 2009/12/19 06:00 [pubmed]
PHST- 2010/05/01 06:00 [medline]
AID - S0929-693X(09)00479-5 [pii]
AID - 10.1016/j.arcped.2009.11.013 [doi]
PST - ppublish
SO  - Arch Pediatr. 2010 Feb;17(2):166-74. doi: 10.1016/j.arcped.2009.11.013. Epub 2009
      Dec 16.


PMID- 20017879
OWN - NLM
STAT- MEDLINE
DCOM- 20100301
LR  - 20091218
IS  - 1466-769X (Electronic)
IS  - 1466-7681 (Linking)
VI  - 11
IP  - 1
DP  - 2010 Jan
TI  - Ontologies of nursing in an age of spiritual pluralism: closed or open worldview?
PG  - 15-23
LID - 10.1111/j.1466-769X.2009.00420.x [doi]
AB  - North American society has undergone a period of sacralization where ideas of
      spirituality have increasingly been infused into the public domain. This
      sacralization is particularly evident in the nursing discourse where it is common
      to find claims about the nature of persons as inherently spiritual, about what a 
      spiritually healthy person looks like and about the environment as spiritually
      energetic and interconnected. Nursing theoretical thinking has also used claims
      about the nature of persons, health, and the environment to attempt to establish 
      a unified ontology for the discipline. However, despite this common ground, there
      has been little discussion about the intersections between nursing philosophic
      thinking and the spirituality in nursing discourse, or about the challenges of
      adopting a common view of these claims within a spiritually pluralist society.
      The purpose of this paper is to discuss the call for ontological unity within
      nursing philosophic thinking in the context of the sacralization of a diverse
      society. I will begin with a discussion of secularization and sacralization,
      illustrating the diversity of beliefs and experiences that characterize the
      current trend towards sacralization. I will then discuss the challenges of a
      unified ontological perspective, or closed world view, for this diversity, using 
      examples from both a naturalistic and a unitary perspective. I will conclude by
      arguing for a unified approach within nursing ethics rather than nursing
      ontology.
FAU - Pesut, Barbara
AU  - Pesut B
AD  - University of British Columbia Okanagan, BC, Canada V1V 1V7. barb.pesut@ubc.ca
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Philos
JT  - Nursing philosophy : an international journal for healthcare professionals
JID - 100897394
SB  - IM
CIN - Nurs Philos. 2010 Jan;11(1):24. PMID: 20017880
MH  - *Cultural Diversity
MH  - Holistic Health
MH  - Holistic Nursing/ethics/organization & administration
MH  - Humanism
MH  - Humans
MH  - Metaphysics
MH  - North America
MH  - *Nursing Theory
MH  - *Philosophy, Nursing
MH  - Religion and Psychology
MH  - Secularism
MH  - Social Change
MH  - *Spirituality
MH  - Thinking
MH  - Transcultural Nursing/ethics/organization & administration
EDAT- 2009/12/19 06:00
MHDA- 2010/03/02 06:00
CRDT- 2009/12/19 06:00
PHST- 2009/12/19 06:00 [entrez]
PHST- 2009/12/19 06:00 [pubmed]
PHST- 2010/03/02 06:00 [medline]
AID - NUP420 [pii]
AID - 10.1111/j.1466-769X.2009.00420.x [doi]
PST - ppublish
SO  - Nurs Philos. 2010 Jan;11(1):15-23. doi: 10.1111/j.1466-769X.2009.00420.x.


PMID- 20017746
OWN - NLM
STAT- MEDLINE
DCOM- 20100318
LR  - 20091218
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 24
IP  - 1
DP  - 2010 Jan
TI  - Ethical issues in forensic psychiatric research on mentally disordered offenders.
PG  - 35-44
LID - 10.1111/j.1467-8519.2009.01773.x [doi]
AB  - This paper analyses ethical issues in forensic psychiatric research on mentally
      disordered offenders, especially those detained in the psychiatric treatment
      system. The idea of a 'dual role' dilemma afflicting forensic psychiatry is more 
      complicated than acknowledged. Our suggestion acknowledges the good of criminal
      law and crime prevention as a part that should be balanced against familiar
      research ethical considerations. Research aiming at improvements of criminal
      justice and treatment is a societal priority, and the total benefit of studies
      has to be balanced against the risks for research subjects inferred by almost all
      systematic studies. Direct substantial risks must be balanced by health benefits,
      and normal informed consent requirements apply. When direct risks are slight, as 
      in register-based epidemiology, lack of consent may be counter-balanced by
      special measures to protect integrity and the general benefit of better
      understanding of susceptibility, treatment and prevention. Special requirements
      on consent procedures in the forensic psychiatric context are suggested, and the 
      issue of the relation between decision competence and legal accountability is
      found to be in need of further study. The major ethical hazard in forensic
      psychiatric research connects to the role of researchers as assessors and
      consultants in a society entertaining strong prejudices against mentally
      disordered offenders.
FAU - Munthe, Christian
AU  - Munthe C
AD  - University of Gothenburg. christian.munthe@phil.gu.se
FAU - Radovic, Susanna
AU  - Radovic S
FAU - Anckarsater, Henrik
AU  - Anckarsater H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Commitment of Mentally Ill/legislation & jurisprudence
MH  - Criminal Law/ethics/legislation & jurisprudence
MH  - Developed Countries
MH  - Ethical Analysis
MH  - Ethical Theory
MH  - *Ethics, Research
MH  - Forensic Psychiatry/*ethics/organization & administration
MH  - Human Experimentation/*ethics/legislation & jurisprudence
MH  - Humans
MH  - Information Dissemination/ethics/legislation & jurisprudence
MH  - Informed Consent/ethics/legislation & jurisprudence
MH  - Mental Competency/legislation & jurisprudence
MH  - *Mentally Ill Persons/legislation & jurisprudence
MH  - *Prisoners/legislation & jurisprudence
MH  - Risk Assessment
MH  - Vulnerable Populations/legislation & jurisprudence
EDAT- 2009/12/19 06:00
MHDA- 2010/03/20 06:00
CRDT- 2009/12/19 06:00
PHST- 2009/12/19 06:00 [entrez]
PHST- 2009/12/19 06:00 [pubmed]
PHST- 2010/03/20 06:00 [medline]
AID - BIOT1773 [pii]
AID - 10.1111/j.1467-8519.2009.01773.x [doi]
PST - ppublish
SO  - Bioethics. 2010 Jan;24(1):35-44. doi: 10.1111/j.1467-8519.2009.01773.x.


PMID- 20017744
OWN - NLM
STAT- MEDLINE
DCOM- 20100318
LR  - 20191210
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 24
IP  - 1
DP  - 2010 Jan
TI  - Prisoner research - looking back or looking forward?
PG  - 23-6
LID - 10.1111/j.1467-8519.2009.01777.x [doi]
AB  - Much has been written about prisoner research and the controversies surrounding
      prisoners as human subjects. The Institute of Medicine recently released a report
      addressing some of these issues. This report, which generated further
      controversy, needs to be fully discussed in the literature and certain aspects
      are examined in this work. Further, in the body of literature there has been
      little acknowledgement of the concept of the right of prisoners to be involved in
      research. This needs to be pursued from an ethical perspective and eventually a
      legal one. This paper explores that concept and documents some facilities in
      which a prisoner's right to research has occurred.
FAU - Thomas, David L
AU  - Thomas DL
AD  - Department of Surgery at Nova Southeastern University College of Osteopathic
      Medicine, Ft. Lauderdale, Florida 33328, USA. davithom@nova.edu
LA  - eng
PT  - Journal Article
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
CIN - Bioethics. 2011 Jan;25(1):55-6. PMID: 21158873
MH  - Dissent and Disputes
MH  - *Ethics, Research
MH  - Federal Government
MH  - Forecasting
MH  - Government Regulation
MH  - Guidelines as Topic
MH  - Health Planning Guidelines
MH  - *Health Services Accessibility/ethics/legislation & jurisprudence
MH  - *Human Experimentation/ethics/legislation & jurisprudence
MH  - *Human Rights/legislation & jurisprudence
MH  - Humans
MH  - National Academies of Science, Engineering, and Medicine, U.S., Health and
      Medicine Division
MH  - Patient Participation/legislation & jurisprudence
MH  - Principle-Based Ethics
MH  - *Prisoners
MH  - Research Support as Topic/ethics/legislation & jurisprudence
MH  - United States
MH  - Vulnerable Populations/legislation & jurisprudence
EDAT- 2009/12/19 06:00
MHDA- 2010/03/20 06:00
CRDT- 2009/12/19 06:00
PHST- 2009/12/19 06:00 [entrez]
PHST- 2009/12/19 06:00 [pubmed]
PHST- 2010/03/20 06:00 [medline]
AID - BIOT1777 [pii]
AID - 10.1111/j.1467-8519.2009.01777.x [doi]
PST - ppublish
SO  - Bioethics. 2010 Jan;24(1):23-6. doi: 10.1111/j.1467-8519.2009.01777.x.


PMID- 20017743
OWN - NLM
STAT- MEDLINE
DCOM- 20100318
LR  - 20191210
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 24
IP  - 1
DP  - 2010 Jan
TI  - Against risk-benefit review of prisoner research.
PG  - 14-22
LID - 10.1111/j.1467-8519.2009.01775.x [doi]
AB  - The 2006 Institute of Medicine (IOM) report, 'Ethical Considerations for Research
      Involving Prisoners', recommended five main changes to current US Common Rule
      regulations on prisoner research. Their third recommendation was to shift from a 
      category-based to a risk-benefit approach to research review, similar to current 
      guidelines on pediatric research. However, prisoners are not children, so
      risk-benefit constraints on prisoner research must be justified in a different
      way from those on pediatric research. In this paper I argue that additional
      risk-benefit constraints on prisoner research are unnecessary: the current Common
      Rule regulations, omitting category-based restrictions but conjoined with the IOM
      report's other four main recommendations, ensure that prisoner research is as
      ethical as non-prisoner research is. I explain why four problems which which may 
      be more prevalent in prisons and which risk-benefit constraints may seem to
      address - coercion, undue inducements, exploitation, and protection from harm -
      are in fact not solved by adding further risk-benefit constraints on prisoner
      research.
FAU - Chwang, Eric
AU  - Chwang E
AD  - National Institutes of Health, USA. chwang@colorado.edu
LA  - eng
PT  - Journal Article
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
CIN - Bioethics. 2011 Jan;25(1):55-6. PMID: 21158873
MH  - Adult
MH  - Child
MH  - Child Advocacy/ethics
MH  - Choice Behavior
MH  - Coercion
MH  - Dissent and Disputes
MH  - Ethics, Research
MH  - Freedom
MH  - Government Regulation
MH  - *Guidelines as Topic
MH  - Health Planning Guidelines
MH  - Human Experimentation/*ethics/legislation & jurisprudence
MH  - Humans
MH  - Mental Competency
MH  - Motivation
MH  - National Academies of Science, Engineering, and Medicine, U.S., Health and
      Medicine Division/organization & administration
MH  - Paternalism/ethics
MH  - Peer Review, Research/legislation & jurisprudence/*methods
MH  - *Prisoners/legislation & jurisprudence/psychology
MH  - Risk Assessment/*organization & administration
MH  - United States
MH  - Vulnerable Populations/legislation & jurisprudence/psychology
EDAT- 2009/12/19 06:00
MHDA- 2010/03/20 06:00
CRDT- 2009/12/19 06:00
PHST- 2009/12/19 06:00 [entrez]
PHST- 2009/12/19 06:00 [pubmed]
PHST- 2010/03/20 06:00 [medline]
AID - BIOT1775 [pii]
AID - 10.1111/j.1467-8519.2009.01775.x [doi]
PST - ppublish
SO  - Bioethics. 2010 Jan;24(1):14-22. doi: 10.1111/j.1467-8519.2009.01775.x.


PMID- 20017742
OWN - NLM
STAT- MEDLINE
DCOM- 20100318
LR  - 20191210
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 24
IP  - 1
DP  - 2010 Jan
TI  - Research on prisoners - a comparison between the IOM Committee recommendations
      (2006) and European regulations.
PG  - 1-13
LID - 10.1111/j.1467-8519.2009.01776.x [doi]
AB  - The Institute of Medicine (IOM) Committee on Ethical Considerations for Revisions
      to DHHS Regulations for Protection of Prisoners Involved in Research published
      its report in 2006. It was charged with developing an ethical framework for the
      conduct of research with prisoners and identifying the safeguards and conditions 
      necessary to ensure that research with prisoners is conducted ethically. The
      recommendations contained in the IOM report differ from current European
      regulations in several ways, some being more restrictive and some less so. For
      example, the IOM report suggests limiting the percentage of prisoners that should
      be involved in a biomedical study to 50%, a limit that does not exist in Europe. 
      However, the report does not specifically advise against research without a
      direct benefit to an individual prisoner: the European regulations are more
      restrictive than the IOM committee recommendations in this respect. The
      definition of minimal risk varies, as well as the proposed role of the minimal
      risk requirement and of the principle of subsidiarity (research that can only be 
      done effectively in prisons). The IOM report proposes a number of thoughtful
      suggestions, which it would be beneficial to implement everywhere, such as
      registers of research on prisoners. The European regulations offer pragmatic
      solutions to several thorny issues. In summary, the IOM committee report
      represents an admirable effort to tackle the present inconsistencies and
      deficiencies of federal regulations in the US on research on prisoners (45 CFR 46
      Subpart C). Nonetheless, before acting on the recommendations, US regulators
      might consider revisiting international guidelines such as those published by the
      Council for International Organizations of Medical Science (CIOMS) and the
      Declaration of Helsinki.
FAU - Elger, Bernice S
AU  - Elger BS
AD  - University of Geneva. Bernice.Elger@unige.ch
FAU - Spaulding, Anne
AU  - Spaulding A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
CIN - Bioethics. 2011 Jan;25(1):55-6. PMID: 21158873
MH  - Advisory Committees/organization & administration
MH  - Clinical Trials as Topic/ethics
MH  - Coercion
MH  - *Ethics, Research
MH  - Europe
MH  - Government Regulation
MH  - *Guidelines as Topic
MH  - Health Planning Guidelines
MH  - Helsinki Declaration
MH  - Human Experimentation/*ethics/legislation & jurisprudence/statistics & numerical 
      data
MH  - Humans
MH  - National Academies of Science, Engineering, and Medicine, U.S., Health and
      Medicine Division/*organization & administration
MH  - Principle-Based Ethics
MH  - *Prisoners/legislation & jurisprudence/statistics & numerical data
MH  - Research Subjects
MH  - Risk Assessment/ethics
MH  - Therapeutic Human Experimentation/ethics
MH  - United States
EDAT- 2009/12/19 06:00
MHDA- 2010/03/20 06:00
CRDT- 2009/12/19 06:00
PHST- 2009/12/19 06:00 [entrez]
PHST- 2009/12/19 06:00 [pubmed]
PHST- 2010/03/20 06:00 [medline]
AID - BIOT1776 [pii]
AID - 10.1111/j.1467-8519.2009.01776.x [doi]
PST - ppublish
SO  - Bioethics. 2010 Jan;24(1):1-13. doi: 10.1111/j.1467-8519.2009.01776.x.


PMID- 20017050
OWN - NLM
STAT- MEDLINE
DCOM- 20100301
LR  - 20181201
IS  - 1532-7604 (Electronic)
IS  - 1088-8705 (Linking)
VI  - 13
IP  - 1
DP  - 2010
TI  - Thinking outside our cages.
PG  - 96-9
LID - 10.1080/10888700903372283 [doi]
AB  - Researchers seem to be stuck reiterating the now-familiar argument that barren
      boxes are bad for welfare and that rodents are due ethical consideration. But the
      prerequisites for real progress are new kinds of arguments, new types of data,
      and removal of very real practical and cultural obstacles to implementation of
      meaningful enrichment. We must discover what we have to do to effectively change 
      the practices of people who have care and control of rodents in the laboratory,
      not just husbandry staff but those who develop the institution's protocols, job
      descriptions, and resourcing. Researchers are inventers of information, and like 
      any inventor we should experience no satisfaction until our ideas are fully
      implemented-and we must be an active participant in that process. If we are
      asking animal caretakers to make deep, paradigmatic changes in their thinking, it
      is imperative that we in turn develop an emotionally positive understanding of
      areas important to them. For unless the welfare advocates truly understand the
      issues such as budgets, biosecurity, and branding, why should the people
      responsible for those subjects listen to us?
FAU - Patterson-Kane, Emily
AU  - Patterson-Kane E
AD  - American Veterinary Medical Association, Animal Welfare Division, 1931 North
      Meacham Road #100, Schaumburg, IL 60173-4360, USA. rattitude@gmail.com
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - England
TA  - J Appl Anim Welf Sci
JT  - Journal of applied animal welfare science : JAAWS
JID - 9804404
SB  - IM
CON - J Appl Anim Welf Sci. 2010;13(1):77-88. PMID: 20017048
CIN - J Appl Anim Welf Sci. 2010;13(1):100-2. PMID: 20017051
MH  - Animal Husbandry/ethics
MH  - Animal Welfare
MH  - Animals
MH  - Animals, Laboratory/*psychology
MH  - Housing, Animal/*standards
MH  - Mice/*psychology
MH  - Rats/*psychology
MH  - Workforce
EDAT- 2009/12/18 06:00
MHDA- 2010/03/02 06:00
CRDT- 2009/12/18 06:00
PHST- 2009/12/18 06:00 [entrez]
PHST- 2009/12/18 06:00 [pubmed]
PHST- 2010/03/02 06:00 [medline]
AID - 917885032 [pii]
AID - 10.1080/10888700903372283 [doi]
PST - ppublish
SO  - J Appl Anim Welf Sci. 2010;13(1):96-9. doi: 10.1080/10888700903372283.


PMID- 20015579
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20100303
IS  - 1532-2793 (Electronic)
IS  - 0260-6917 (Linking)
VI  - 30
IP  - 3
DP  - 2010 Apr
TI  - Educating for ethical leadership.
PG  - 224-7
LID - 10.1016/j.nedt.2009.11.003 [doi]
AB  - In this article we consider the nature of ethical leadership in nursing. An
      appreciation of the basis of such leadership requires an understanding of
      responsibility and of key intellectual and ethical qualities or virtues. We
      examine some of the educational and practice strategies to promote ethical
      leadership. We argue that there are different levels of ethical leadership. All
      members of the nursing workforce are ethical leaders in so far as they
      demonstrate a commitment to ethical practice in their everyday work and act as
      ethical role models for others. Nurse managers are responsible for influencing
      their team and for acting as arbiters between organisational and professional
      values. Nurse educators are role models and ethical leaders as they ensure that
      the explicit and hidden curriculum demonstrate a commitment to professional
      values. Nurses who assume political roles have an obligation to lead on ethical
      agenda compatible with the values of nursing.
FAU - Gallagher, Ann
AU  - Gallagher A
AD  - International Centre for Nursing Ethics, Division of Health and Social Care,
      Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey
      GU2 7TE, United Kingdom. a.gallagher@surrey.ac.uk <a.gallagher@surrey.ac.uk>
FAU - Tschudin, Verena
AU  - Tschudin V
LA  - eng
PT  - Journal Article
DEP - 20091216
PL  - Scotland
TA  - Nurse Educ Today
JT  - Nurse education today
JID - 8511379
MH  - *Curriculum
MH  - *Education, Nursing
MH  - Ethics, Nursing/*education
MH  - Humans
MH  - *Leadership
MH  - Morals
MH  - Virtues
EDAT- 2009/12/18 06:00
MHDA- 2011/01/07 06:00
CRDT- 2009/12/18 06:00
PHST- 2009/06/24 00:00 [received]
PHST- 2009/10/22 00:00 [revised]
PHST- 2009/11/09 00:00 [accepted]
PHST- 2009/12/18 06:00 [entrez]
PHST- 2009/12/18 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
AID - S0260-6917(09)00215-9 [pii]
AID - 10.1016/j.nedt.2009.11.003 [doi]
PST - ppublish
SO  - Nurse Educ Today. 2010 Apr;30(3):224-7. doi: 10.1016/j.nedt.2009.11.003. Epub
      2009 Dec 16.


PMID- 20015161
OWN - NLM
STAT- MEDLINE
DCOM- 20100803
LR  - 20111117
IS  - 1365-2788 (Electronic)
IS  - 0964-2633 (Linking)
VI  - 54
IP  - 2
DP  - 2010 Feb
TI  - Living 'a life like ours': support workers' accounts of substitute
      decision-making in residential care homes for adults with intellectual
      disabilities.
PG  - 144-60
LID - 10.1111/j.1365-2788.2009.01228.x [doi]
AB  - In England and Wales, the Mental Capacity Act 2005 (MCA) provides a new legal
      framework to regulate substitute decision-making relating to the welfare of
      adults who lack the capacity to make one or more autonomous decisions about their
      care and support. Any substitute decision made on behalf of an adult lacking
      capacity must be in his/her 'best interests'. However, the value of adopting
      established principles and procedures for substitute decision-making in practice 
      is uncertain, and little is known about the legal or ethical dynamics of social
      care support, including the day-to-day residential support provided to adults
      with intellectual disabilities (ID). Methods This paper reports a qualitative,
      grounded theory analysis of 21 interviews with support workers working in
      residential care homes for adults with ID, and observations of care practices.
      Results In contrast to the narrow legal responsibilities placed upon them, it is 
      argued that support workers interpret substitute decision-making within a broad
      moral account of their care role, orientating their support towards helping
      residents to live 'a life like ours'. In so doing, support workers describe how
      they draw on their own values and life experiences to shape the substitute
      decisions that they make on behalf of residents. Conclusions Support workers'
      accounts reveal clear discrepancies between the legal regulation of substitute
      decision-making and the ways that these support workers make sense of their work.
      Such discrepancies have implications both for the implementation of the MCA, and 
      for the role of support workers' values in the conceptualisation and delivery of 
      'good' care.
FAU - Dunn, M C
AU  - Dunn MC
AD  - The Ethox Centre, University of Oxford, UK. michael.dunn@ethox.ox.ac.uk
FAU - Clare, I C H
AU  - Clare IC
FAU - Holland, A J
AU  - Holland AJ
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091214
PL  - England
TA  - J Intellect Disabil Res
JT  - Journal of intellectual disability research : JIDR
JID - 9206090
SB  - IM
MH  - Adult
MH  - Attitude of Health Personnel
MH  - Decision Making/*ethics
MH  - England
MH  - Group Homes/ethics/*legislation & jurisprudence
MH  - Humans
MH  - Independent Living
MH  - Inservice Training
MH  - Intellectual Disability/*rehabilitation
MH  - *Personal Autonomy
MH  - Quality Assurance, Health Care
MH  - Residential Facilities/ethics/*legislation & jurisprudence
MH  - Risk-Taking
MH  - *Social Support
MH  - Socialization
MH  - Wales
EDAT- 2009/12/18 06:00
MHDA- 2010/08/04 06:00
CRDT- 2009/12/18 06:00
PHST- 2009/12/18 06:00 [entrez]
PHST- 2009/12/18 06:00 [pubmed]
PHST- 2010/08/04 06:00 [medline]
AID - JIR1228 [pii]
AID - 10.1111/j.1365-2788.2009.01228.x [doi]
PST - ppublish
SO  - J Intellect Disabil Res. 2010 Feb;54(2):144-60. doi:
      10.1111/j.1365-2788.2009.01228.x. Epub 2009 Dec 14.


PMID- 20014278
OWN - NLM
STAT- MEDLINE
DCOM- 20100514
LR  - 20211203
IS  - 1549-4918 (Electronic)
IS  - 1066-5099 (Linking)
VI  - 28
IP  - 2
DP  - 2010 Feb
TI  - Oct4 and klf4 reprogram dermal papilla cells into induced pluripotent stem cells.
PG  - 221-8
LID - 10.1002/stem.281 [doi]
AB  - Direct reprogramming of somatic cells into induced pluripotent stem (iPS) cells
      by only four transcription factors (Oct4, Sox2, Klf4, and c-Myc) has great
      potential for tissue-specific regenerative therapies, eliminating the ethical
      issues surrounding the use of embryonic stem cells and the rejection problems of 
      using non-autologous cells. The reprogramming efficiency generally is very low,
      however, and the problems surrounding the introduction of viral genetic material 
      are only partially investigated. Recent efforts to reduce the number of virally
      expressed transcription factors succeeded at reprogramming neural stem cells into
      iPS cells by overexpressing Oct4 alone. However, the relative inaccessibility and
      difficulty of obtaining neural cells in humans remains to be resolved. Here we
      report that dermal papilla (DP) cells, which are specialized skin fibroblasts
      thought to instruct hair follicle stem cells, endogenously express high levels of
      Sox2 and c-Myc, and that these cells can be reprogrammed into iPS cells with only
      Oct4 and Klf4. Moreover, we show that DP cells are reprogrammed more efficiently 
      than skin and embryonic fibroblasts. iPS cells derived from DP cells expressed
      pluripotency genes and differentiated into cells from all germ layers in vitro
      and widely contributed to chimeric mice in vivo, including the germline. Our work
      establishes DP cells as an easily accessible source to generate iPS cells with
      efficiency and with less genetic material. This opens up the possibility of
      streamlined generation of skin-derived, patient-specific pluripotent stem cells
      and of ultimately replacing the remaining two factors with small molecules for
      safe generation of transplantable cells.
FAU - Tsai, Su-Yi
AU  - Tsai SY
AD  - Black Family Stem Cell Institute,Mount Sinai School of Medicine, New York, New
      York 10029, USA.
FAU - Clavel, Carlos
AU  - Clavel C
FAU - Kim, Soo
AU  - Kim S
FAU - Ang, Yen-Sin
AU  - Ang YS
FAU - Grisanti, Laura
AU  - Grisanti L
FAU - Lee, Dung-Fang
AU  - Lee DF
FAU - Kelley, Kevin
AU  - Kelley K
FAU - Rendl, Michael
AU  - Rendl M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Stem Cells
JT  - Stem cells (Dayton, Ohio)
JID - 9304532
RN  - 0 (Gonadotropins, Equine)
RN  - 0 (KLF4 protein, human)
RN  - 0 (Klf4 protein, mouse)
RN  - 0 (Kruppel-Like Factor 4)
RN  - 0 (Kruppel-Like Transcription Factors)
RN  - 0 (Octamer Transcription Factor-3)
RN  - 0 (SOXB1 Transcription Factors)
RN  - 0 (Sox2 protein, mouse)
SB  - IM
MH  - Animals
MH  - Cells, Cultured
MH  - Cellular Reprogramming/genetics/*physiology
MH  - Dermis/*cytology/metabolism
MH  - Female
MH  - Fibroblasts/cytology
MH  - Gonadotropins, Equine
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*cytology
MH  - Kruppel-Like Factor 4
MH  - Kruppel-Like Transcription Factors/genetics/*metabolism
MH  - Male
MH  - Mice
MH  - Mice, Mutant Strains
MH  - Mice, Transgenic
MH  - Octamer Transcription Factor-3/genetics/*metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - SOXB1 Transcription Factors
EDAT- 2009/12/17 06:00
MHDA- 2010/05/15 06:00
CRDT- 2009/12/17 06:00
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2010/05/15 06:00 [medline]
AID - 10.1002/stem.281 [doi]
PST - ppublish
SO  - Stem Cells. 2010 Feb;28(2):221-8. doi: 10.1002/stem.281.


PMID- 20013958
OWN - NLM
STAT- MEDLINE
DCOM- 20100329
LR  - 20100105
IS  - 1520-6394 (Electronic)
IS  - 1091-4269 (Linking)
VI  - 27
IP  - 1
DP  - 2010
TI  - Efficacy of interpersonal therapy-group format adapted to post-traumatic stress
      disorder: an open-label add-on trial.
PG  - 72-7
LID - 10.1002/da.20610 [doi]
AB  - BACKGROUND: Post-traumatic stress disorder (PTSD) is a highly prevalent
      condition, yet available treatments demonstrate only modest efficacy. Exposure
      therapies, considered by many to be the "gold-standard" therapy for PTSD, are
      poorly tolerated by many patients and show high attrition. We evaluated
      interpersonal therapy, in a group format, adapted to PTSD (IPT-G PTSD), as an
      adjunctive treatment for patients who failed to respond to conventional
      psychopharmacological treatment. METHODS: Research participants included 40
      patients who sought treatment through a program on violence in the department of 
      psychiatry of Federal University of Sao Paulo (UNIFESP). They had received
      conventional psychopharmacological treatment for at least 12 weeks and failed to 
      have an adequate clinical response. After signing an informed consent, approved
      earlier by the UNIFESP Ethics Review Board, they received a semi-structured
      diagnostic interview (SCID-I), administered by a trained mental health worker, to
      confirm the presence of a PTSD diagnosis according to DSM-IV criteria. Other
      instruments were administered, and patients completed out self-report instruments
      at baseline, and endpoint to evaluate clinical outcomes. RESULTS: Thirty-three
      patients completed the trial, but all had at least one second outcome evaluation.
      There were significant improvements on all measures, with large effect sizes.
      CONCLUSIONS: IPT-G PTSD was effective not only in decreasing symptoms of PTSD,
      but also in decreasing symptoms of anxiety and depression. It led to significant 
      improvements in social adjustment and quality of life. It was well tolerated and 
      there were few dropouts. Our results are very preliminary; they need further
      confirmation through randomized controlled clinical trials.
FAU - Campanini, Rosaly F B
AU  - Campanini RF
AD  - Program for Victims of Violence of the Department of Psychiatry, Federal
      University of Sao Paulo (UNIFESP), Sao Paulo, Sao Paulo, Brazil.
      rosapsibr@yahoo.com.br
FAU - Schoedl, Aline F
AU  - Schoedl AF
FAU - Pupo, Mariana C
AU  - Pupo MC
FAU - Costa, Ana Clara H
AU  - Costa AC
FAU - Krupnick, Janice L
AU  - Krupnick JL
FAU - Mello, Marcelo F
AU  - Mello MF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Depress Anxiety
JT  - Depression and anxiety
JID - 9708816
RN  - 0 (Psychotropic Drugs)
SB  - IM
MH  - Adult
MH  - Affect
MH  - Aged
MH  - Anxiety Disorders/diagnosis/psychology/therapy
MH  - Combined Modality Therapy
MH  - Comorbidity
MH  - Depressive Disorder/diagnosis/psychology/therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Personality Inventory
MH  - Psychotherapy, Group/*methods
MH  - Psychotropic Drugs/therapeutic use
MH  - Social Isolation
MH  - Stress Disorders, Post-Traumatic/diagnosis/psychology/*therapy
MH  - Treatment Outcome
MH  - Trust
MH  - Violence/psychology
MH  - Young Adult
EDAT- 2009/12/17 06:00
MHDA- 2010/03/30 06:00
CRDT- 2009/12/17 06:00
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2010/03/30 06:00 [medline]
AID - 10.1002/da.20610 [doi]
PST - ppublish
SO  - Depress Anxiety. 2010;27(1):72-7. doi: 10.1002/da.20610.


PMID- 20012907
OWN - NLM
STAT- MEDLINE
DCOM- 20100524
LR  - 20211020
IS  - 1433-7339 (Electronic)
IS  - 0941-4355 (Linking)
VI  - 18
IP  - 4
DP  - 2010 Apr
TI  - Defunctioning stoma in high ASA grade, aged patients, with bowel occlusion due to
      advanced cancer: is it still worthwhile?
PG  - 523-7
LID - 10.1007/s00520-009-0795-z [doi]
AB  - PURPOSE: The aim of this study was to assess the role of defunctioning stoma (DS)
      in elderly high-risk patients with bowel obstruction from advanced colorectal
      cancer, by exploring consistent variables of outcome, because every other
      procedure was unfeasible. MATERIALS AND METHODS: A 6-year survey in a single
      surgery unit (between 1999 and 2004) was retrospectively evaluated, allowing to
      collect a cohort of 75 patients, aged over 65, who overall presented such
      critical condition. Pre-operatively, American Society of Anaesthesiologist grade 
      classification was used. Post-operative course was monitored by focusing on
      gauging symptom relief. So, a validated assessment scale was employed to evaluate
      physical distress symptoms, graduated on a Likert scale and compared at baseline 
      and day 7, on days 7 and 30, post-operatively. Length of hospital stay (LHS),
      morbidity, in-hospital (within 30 days) and overall mortality (within 6 months)
      were also assessed. Paired t test was used as statistical analysis to ascertain
      improvement of symptoms. RESULTS: All symptoms improved significantly (range, p <
      0.05 to p < 0.01) within the surveyed time, with exception of vomiting on day 30 
      (p = 0.14). Average LHS was 22.8 (standard deviation, +/-3.856) days. Overall
      morbidity was detected in 68 (91%) patients. In-hospital and overall mortality
      rates accounted for 27 (35.8%) patients and for 48 (100%) patients, respectively.
      CONCLUSIONS: The role of DS was effective to improve symptom relief but was poor 
      in terms of morbidity and mortality control. So, ethical concerns have to be
      addressed, and medical treatment or stenting for left-side obstructions only
      should be considered as alternative procedures.
FAU - Asteria, Corrado R
AU  - Asteria CR
AD  - Department of Surgery and Orthopaedics, Azienda Ospedaliera C Poma Mantua, Piazza
      80th Fanteria 1, 46041 Asola, MN, Italy. corrado.asteria@libero.it
FAU - Nesi, Gabriella
AU  - Nesi G
FAU - Minari, Chiara
AU  - Minari C
FAU - Vigano, Paolo
AU  - Vigano P
LA  - eng
PT  - Journal Article
DEP - 20091213
PL  - Germany
TA  - Support Care Cancer
JT  - Supportive care in cancer : official journal of the Multinational Association of 
      Supportive Care in Cancer
JID - 9302957
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Colorectal Neoplasms/mortality/physiopathology/*surgery
MH  - Data Collection
MH  - Female
MH  - Hospital Mortality
MH  - Humans
MH  - Intestinal Obstruction/etiology/*surgery
MH  - Length of Stay
MH  - Male
MH  - Retrospective Studies
MH  - Risk Factors
MH  - *Surgical Stomas
MH  - Treatment Outcome
EDAT- 2009/12/17 06:00
MHDA- 2010/05/25 06:00
CRDT- 2009/12/17 06:00
PHST- 2009/09/22 00:00 [received]
PHST- 2009/11/25 00:00 [accepted]
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2010/05/25 06:00 [medline]
AID - 10.1007/s00520-009-0795-z [doi]
PST - ppublish
SO  - Support Care Cancer. 2010 Apr;18(4):523-7. doi: 10.1007/s00520-009-0795-z. Epub
      2009 Dec 13.


PMID- 20012739
OWN - NLM
STAT- MEDLINE
DCOM- 20140522
LR  - 20181201
IS  - 0724-6145 (Print)
IS  - 0724-6145 (Linking)
VI  - 123
DP  - 2010
TI  - Mesenchymal stromal cells derived from human umbilical cord tissues: primitive
      cells with potential for clinical and tissue engineering applications.
PG  - 29-54
LID - 10.1007/10_2009_15 [doi]
AB  - Mesenchymal stem or stromal cells (MSCs) have a high potential for cell-based
      therapies as well as for tissue engineering applications. Since Friedenstein
      first isolated stem or precursor cells from the human bone marrow (BM) stroma
      that were capable of osteogenesis, BM is currently the most common source for
      MSCs. However, BM presents several disadvantages, namely low frequency of MSCs,
      high donor-dependent variations in quality, and painful invasive intervention.
      Thus, tremendous research efforts have been observed during recent years to find 
      alternative sources for MSCs.In this context, the human umbilical cord (UC) has
      gained more and more attention. Since the UC is discarded after birth, the cells 
      are easily accessible without ethical concerns. This postnatal organ was found to
      be rich in primitive stromal cells showing typical characteristics of bone-marrow
      MSCs (BMSCs), e.g., they grow as plastic-adherent cells with a fibroblastic
      morphology, express a set of typical surface markers, and can be directly
      differentiated at least along mesodermal lineages. Compared to BM, the UC tissue 
      bears a higher frequency of stromal cells with a higher in vitro expansion
      potential. Furthermore, immune-privileged and immune-modulatory properties are
      reported for UC-derived cells, which open highly interesting perspectives for
      clinical applications.
FAU - Moretti, Pierre
AU  - Moretti P
AD  - Institut fur Technische Chemie, Leibniz Universitat Hannover, Callinstrasse, 5,
      30167, Hannover, Germany, Moretti@iftc.uni-hannover.de.
FAU - Hatlapatka, Tim
AU  - Hatlapatka T
FAU - Marten, Dana
AU  - Marten D
FAU - Lavrentieva, Antonina
AU  - Lavrentieva A
FAU - Majore, Ingrida
AU  - Majore I
FAU - Hass, Ralf
AU  - Hass R
FAU - Kasper, Cornelia
AU  - Kasper C
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Adv Biochem Eng Biotechnol
JT  - Advances in biochemical engineering/biotechnology
JID - 8307733
SB  - IM
MH  - Animals
MH  - Cell Culture Techniques/*methods
MH  - Cell Differentiation/physiology
MH  - Cell Proliferation
MH  - Cell Separation/*methods
MH  - Cells, Cultured
MH  - Humans
MH  - Mesenchymal Stem Cells/*cytology/*physiology
MH  - Tissue Engineering/*methods
MH  - Umbilical Cord/*cytology/*physiology
EDAT- 2009/12/17 06:00
MHDA- 2014/05/23 06:00
CRDT- 2009/12/17 06:00
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2014/05/23 06:00 [medline]
AID - 10.1007/10_2009_15 [doi]
PST - ppublish
SO  - Adv Biochem Eng Biotechnol. 2010;123:29-54. doi: 10.1007/10_2009_15.


PMID- 20012591
OWN - NLM
STAT- MEDLINE
DCOM- 20100430
LR  - 20160707
IS  - 1437-1588 (Electronic)
IS  - 1436-9990 (Linking)
VI  - 53
IP  - 1
DP  - 2010 Jan
TI  - [Ethical aspects of human embryonic stem cell use and commercial umbilical cord
      blood stem cell banking. Ethical reflections on the occasion of the regulation of
      the European Council and Parliament on advanced therapy medicinal products].
PG  - 63-7
LID - 10.1007/s00103-009-0994-2 [doi]
AB  - The regulation of the European Council and Parliament on advanced therapy
      medicinal products also includes therapies with human embryonic stem cells. The
      use of these stem cells is controversially and heavily discussed. Contrary to the
      use of adult stem cells, medical and ethical problems concerning the use of human
      embryonic stem cells persists, because this use is based on the destruction of
      human life at the very beginning. The regulation foresees, therefore,
      subsidiarity within the European Member States. Although there are no ethical
      problems in principle with the use of stem cells from the umbilical cord blood,
      there are social ethical doubts with the banking of these stem cells for
      autologous use without any currently foreseeable medical advantage by commercial 
      blood banks. Also in this case subsidiarity is valid.
FAU - Virt, G
AU  - Virt G
AD  - guenter.virt@univie.ac.at
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Bioethische und sozialethische Probleme bei der Verwendung von Geweben aus
      humanen embryonalen Stammzellen sowie der Aufbewahrung von Stammzellen aus dem
      Nabelschnurblut durch private Firmen zum autologen Gebrauch. Ethische
      Uberlegungen anlasslich der Verordnung (EG) Nr. 1394/2007 des europaischen
      Parlaments und des Rates uber Arzneimittel fur Neuartige Therapien.
PL  - Germany
TA  - Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
JT  - Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
JID - 101181368
RN  - 0 (Biological Products)
SB  - IM
MH  - Biological Products/*standards
MH  - Biological Therapy/*ethics
MH  - Cord Blood Stem Cell Transplantation/*ethics/legislation & jurisprudence
MH  - Embryo Research/*ethics/legislation & jurisprudence
MH  - *Embryonic Stem Cells
MH  - *Ethics, Research
MH  - Europe
MH  - Humans
MH  - Private Sector/legislation & jurisprudence
MH  - Tissue Banks/*ethics/legislation & jurisprudence
EDAT- 2009/12/17 06:00
MHDA- 2010/05/01 06:00
CRDT- 2009/12/17 06:00
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2010/05/01 06:00 [medline]
AID - 10.1007/s00103-009-0994-2 [doi]
PST - ppublish
SO  - Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2010
      Jan;53(1):63-7. doi: 10.1007/s00103-009-0994-2.


PMID- 20010263
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20091216
IS  - 1538-9855 (Electronic)
IS  - 0363-3624 (Linking)
VI  - 35
IP  - 1
DP  - 2010 Jan-Feb
TI  - Using data from the internet to teach ethical principles for critiquing research 
      studies.
PG  - 17-9
LID - 10.1097/NNE.0b013e3181c41f8d [doi]
AB  - Qualitative researchers are increasingly using the Internet to conduct their
      studies; however, they need to adhere to the same ethical principles used when
      conducting traditional research studies. Students also must be aware of these
      ethical principles and know how to critique research reports for adherence to
      them. The authors describe selected ethical principles as they relate to Internet
      qualitative research, what students need to know, what faculty must teach them to
      critique those studies, and what decisions students must make once the critique
      is completed.
FAU - Sherrod, Roy Ann
AU  - Sherrod RA
AD  - Capstone College of Nursing, The University of Alabama, Box 870358, Tuscaloosa,
      AL 35487-0358, USA. rsherrod@bama.ua.edu
FAU - Ford, Cassandra
AU  - Ford C
FAU - Oliver, JoAnn
AU  - Oliver J
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Nurse Educ
JT  - Nurse educator
JID - 7701902
MH  - Curriculum
MH  - Data Collection/methods
MH  - Ethics, Research/*education
MH  - Faculty, Nursing
MH  - Humans
MH  - *Internet
MH  - *Nursing Education Research
MH  - Qualitative Research
MH  - Students, Nursing
MH  - *Teaching
RF  - 10
EDAT- 2009/12/17 06:00
MHDA- 2011/01/07 06:00
CRDT- 2009/12/17 06:00
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
AID - 10.1097/NNE.0b013e3181c41f8d [doi]
AID - 00006223-201001000-00010 [pii]
PST - ppublish
SO  - Nurse Educ. 2010 Jan-Feb;35(1):17-9. doi: 10.1097/NNE.0b013e3181c41f8d.


PMID- 20010045
OWN - NLM
STAT- MEDLINE
DCOM- 20100108
LR  - 20220310
IS  - 1538-9847 (Electronic)
IS  - 0029-6562 (Linking)
VI  - 59
IP  - 1
DP  - 2010 Jan-Feb
TI  - Research coordinators' experiences with scientific misconduct and research
      integrity.
PG  - 51-7
LID - 10.1097/NNR.0b013e3181c3b9f2 [doi]
AB  - BACKGROUND: Most reports of scientific misconduct have been focused on principal 
      investigators and other scientists (e.g., biostatisticians) involved in the
      research enterprise. However, by virtue of their position, research coordinators 
      are often closest to the research field where much of misconduct occurs.
      OBJECTIVE: The purpose of this study was to describe research coordinators'
      experiences with scientific misconduct in their clinical environment. DESIGN: The
      descriptive design was embedded in a larger cross-sectional national survey. A
      total of 266 respondents, predominately registered nurses, who answered "yes" to 
      having firsthand knowledge of scientific misconduct in the past year, provided
      open-ended question responses. METHODS: Content analysis was conducted by the
      research team, ensuring agreement of core categories and subcategories of
      misconduct. FINDINGS: Research coordinators most commonly learned about
      misconduct via firsthand witness of the event, with the principal investigator
      being the person most commonly identified as the responsible party. Five major
      categories of misconduct were identified: protocol violations, consent
      violations, fabrication, falsification, and financial conflict of interest. In
      70% of cases, the misconduct was reported. In most instances where misconduct was
      reported, some action was taken. However, in approximately 14% of cases, no
      action or investigation ensued; in 6.5% of cases, the coordinator was fired or he
      or she resigned. CONCLUSIONS: This study demonstrates the need to expand
      definitions of scientific misconduct beyond fabrication, falsification, and
      plagiarism to include other practices. The importance of the ethical climate in
      the institution in ensuring a safe environment to report and an environment where
      evidence is reviewed cannot be overlooked.
FAU - Habermann, Barbara
AU  - Habermann B
AD  - School of Nursing, Indiana University, Indianapolis, IN 46202, USA.
      habermab@iupui.edu
FAU - Broome, Marion
AU  - Broome M
FAU - Pryor, Erica R
AU  - Pryor ER
FAU - Ziner, Kim Wagler
AU  - Ziner KW
LA  - eng
GR  - R01 NR008802/NR/NINR NIH HHS/United States
GR  - R01 NR008802-02/NR/NINR NIH HHS/United States
GR  - 5R01NR 08802-02/NR/NINR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Nurs Res
JT  - Nursing research
JID - 0376404
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Clinical Nursing Research/*ethics
MH  - *Ethics, Nursing
MH  - Evidence-Based Medicine
MH  - Humans
MH  - Interprofessional Relations
MH  - Nurse's Role
MH  - Nursing Assessment/methods
MH  - Nursing Staff, Hospital/education
MH  - Practice Guidelines as Topic
MH  - Professional Misconduct/*ethics
MH  - Societies, Nursing
MH  - United States
PMC - PMC2877381
MID - NIHMS202900
EDAT- 2009/12/17 06:00
MHDA- 2010/01/09 06:00
CRDT- 2009/12/17 06:00
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2010/01/09 06:00 [medline]
AID - 10.1097/NNR.0b013e3181c3b9f2 [doi]
AID - 00006199-201001000-00008 [pii]
PST - ppublish
SO  - Nurs Res. 2010 Jan-Feb;59(1):51-7. doi: 10.1097/NNR.0b013e3181c3b9f2.


PMID- 20008911
OWN - NLM
STAT- MEDLINE
DCOM- 20110202
LR  - 20101124
IS  - 1464-360X (Electronic)
IS  - 1101-1262 (Linking)
VI  - 20
IP  - 6
DP  - 2010 Dec
TI  - The analysis of the ethical, organizational and legal aspects of Polish biobanks 
      activity.
PG  - 707-10
LID - 10.1093/eurpub/ckp202 [doi]
AB  - BACKGROUND: Biobanks create new opportunities for the public health (Public
      Health Genomics) but need some regulations. Polish biobanks are in the phase of
      dynamic transformations aiming at integrating their activity and adjusting them
      to the international standards. The aim of this article is to present the current
      standards held in the most important Polish institutions collecting biological
      samples. METHODS: A survey was conducted by the questionnaire filled by managers 
      and directors of 24 Polish biobanks. Questions concerned obtaining patient
      informed consent (also a consent to some future researches and access to dates by
      other organizations), protection of privacy, storage of the samples and the
      relevant information, the opinion related to the need of establishing Polish
      national DNA data bank and possibilities of the scientific international
      cooperation. RESULTS: The written consent to carry out research on the samples is
      obtained almost everywhere, but 29% of biabanks does not acquire the consent for 
      the future usage of the samples. Almost all inquired banks (93%, n = 22) declare 
      the willingness to start an international cooperation. Most of respondents
      support the idea of establishing the Polish national DNA bank by the fusion of
      the already existing banks. CONCLUSION: The inquiry findings point that the
      current biobanks procedures do not differ to any relevant degree from procedures 
      applied in the West European countries. Many of Polish biobanking organizations
      are willing to cooperate with foreign sites. It may enhance the European
      biobanking network and gene-environmental research.
FAU - Pawlikowski, Jakub
AU  - Pawlikowski J
AD  - Department of Ethics and Philosophical Anthropology, Medical University of
      Lublin, Poland. jpawlikowski@wp.pl
FAU - Sak, Jaroslaw
AU  - Sak J
FAU - Marczewski, Krzysztof
AU  - Marczewski K
LA  - eng
PT  - Journal Article
DEP - 20091215
PL  - England
TA  - Eur J Public Health
JT  - European journal of public health
JID - 9204966
SB  - IM
MH  - Biological Specimen Banks/ethics/legislation & jurisprudence/*standards
MH  - Biomedical Research/ethics/legislation & jurisprudence/standards
MH  - Confidentiality/ethics/legislation & jurisprudence/*standards
MH  - Health Care Surveys
MH  - Humans
MH  - Informed Consent/ethics/legislation & jurisprudence/*standards
MH  - International Cooperation
MH  - Poland
MH  - Reference Standards
EDAT- 2009/12/17 06:00
MHDA- 2011/02/03 06:00
CRDT- 2009/12/17 06:00
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2011/02/03 06:00 [medline]
AID - ckp202 [pii]
AID - 10.1093/eurpub/ckp202 [doi]
PST - ppublish
SO  - Eur J Public Health. 2010 Dec;20(6):707-10. doi: 10.1093/eurpub/ckp202. Epub 2009
      Dec 15.


PMID- 20008471
OWN - NLM
STAT- MEDLINE
DCOM- 20100901
LR  - 20181201
IS  - 1558-9110 (Electronic)
IS  - 1058-0360 (Linking)
VI  - 19
IP  - 2
DP  - 2010 May
TI  - Experienced speech-language pathologists' responses to ethical dilemmas: an
      integrated approach to ethical reasoning.
PG  - 121-34
LID - 10.1044/1058-0360(2009/08-0007) [doi]
AB  - PURPOSE: To investigate the approaches of experienced speech-language
      pathologists (SLPs) to ethical reasoning and the processes they use to resolve
      ethical dilemmas. METHOD: Ten experienced SLPs participated in in-depth
      interviews. A narrative approach was used to guide participants' descriptions of 
      how they resolved ethical dilemmas. Individual narrative transcriptions were
      analyzed by using the participant's words to develop an ethical story that
      described and interpreted their responses to dilemmas. Key concepts from
      individual stories were then coded into group themes to reflect participants'
      reasoning processes. RESULTS: Five major themes reflected participants'
      approaches to ethical reasoning: (a) focusing on the well-being of the client,
      (b) fulfilling professional roles and responsibilities, (c) attending to
      professional relationships, (d) managing resources, and (e) integrating personal 
      and professional values. SLPs demonstrated a range of ethical reasoning
      processes: applying bioethical principles, casuistry, and narrative reasoning
      when managing ethical dilemmas in the workplace. CONCLUSIONS: The results
      indicate that experienced SLPs adopted an integrated approach to ethical
      reasoning. They supported clients' rights to make health care choices. Bioethical
      principles, casuistry, and narrative reasoning provided useful frameworks for
      facilitating health professionals' application of codes of ethics to complex
      professional practice issues.
FAU - Kenny, Belinda
AU  - Kenny B
AD  - University of Sydney-Speech Pathology, Faculty of Health Sciences, Cumberland
      Campus, Lidcombe, New South Wales 1825, Australia. b.kenny@usyd.edu.au
FAU - Lincoln, Michelle
AU  - Lincoln M
FAU - Balandin, Susan
AU  - Balandin S
LA  - eng
PT  - Journal Article
DEP - 20091214
PL  - United States
TA  - Am J Speech Lang Pathol
JT  - American journal of speech-language pathology
JID - 9114726
SB  - IM
MH  - Adult
MH  - *Ethics
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - *Problem Solving
MH  - *Professional Competence
MH  - *Speech-Language Pathology
MH  - *Teaching
MH  - Workforce
EDAT- 2009/12/17 06:00
MHDA- 2010/09/02 06:00
CRDT- 2009/12/17 06:00
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2010/09/02 06:00 [medline]
AID - 1058-0360_2009_08-0007 [pii]
AID - 10.1044/1058-0360(2009/08-0007) [doi]
PST - ppublish
SO  - Am J Speech Lang Pathol. 2010 May;19(2):121-34. doi:
      10.1044/1058-0360(2009/08-0007). Epub 2009 Dec 14.


PMID- 20008393
OWN - NLM
STAT- MEDLINE
DCOM- 20100322
LR  - 20211020
IS  - 1471-2970 (Electronic)
IS  - 0962-8436 (Linking)
VI  - 365
IP  - 1537
DP  - 2010 Jan 12
TI  - The therapeutic potential of stem cells.
PG  - 155-63
LID - 10.1098/rstb.2009.0149 [doi]
AB  - In recent years, there has been an explosion of interest in stem cells, not just 
      within the scientific and medical communities but also among politicians,
      religious groups and ethicists. Here, we summarize the different types of stem
      cells that have been described: their origins in embryonic and adult tissues and 
      their differentiation potential in vivo and in culture. We review some current
      clinical applications of stem cells, highlighting the problems encountered when
      going from proof-of-principle in the laboratory to widespread clinical practice. 
      While some of the key genetic and epigenetic factors that determine stem cell
      properties have been identified, there is still much to be learned about how
      these factors interact. There is a growing realization of the importance of
      environmental factors in regulating stem cell behaviour and this is being
      explored by imaging stem cells in vivo and recreating artificial niches in vitro.
      New therapies, based on stem cell transplantation or endogenous stem cells, are
      emerging areas, as is drug discovery based on patient-specific pluripotent cells 
      and cancer stem cells. What makes stem cell research so exciting is its
      tremendous potential to benefit human health and the opportunities for
      interdisciplinary research that it presents.
FAU - Watt, Fiona M
AU  - Watt FM
AD  - Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge,
      UK. fiona.watt@cancer.org.uk
FAU - Driskell, Ryan R
AU  - Driskell RR
LA  - eng
GR  - G1100073/MRC_/Medical Research Council/United Kingdom
GR  - WT_/Wellcome Trust/United Kingdom
GR  - CRUK_/Cancer Research UK/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Philos Trans R Soc Lond B Biol Sci
JT  - Philosophical transactions of the Royal Society of London. Series B, Biological
      sciences
JID - 7503623
SB  - IM
MH  - Cell Differentiation/physiology
MH  - Cell Lineage/physiology
MH  - Epigenesis, Genetic
MH  - Humans
MH  - Stem Cell Transplantation/*methods
MH  - Stem Cells/*cytology
RF  - 86
PMC - PMC2842697
EDAT- 2009/12/17 06:00
MHDA- 2010/03/23 06:00
CRDT- 2009/12/17 06:00
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2010/03/23 06:00 [medline]
AID - 365/1537/155 [pii]
AID - 10.1098/rstb.2009.0149 [doi]
PST - ppublish
SO  - Philos Trans R Soc Lond B Biol Sci. 2010 Jan 12;365(1537):155-63. doi:
      10.1098/rstb.2009.0149.


PMID- 20007620
OWN - NLM
STAT- MEDLINE
DCOM- 20100201
LR  - 20131121
IS  - 1468-2060 (Electronic)
IS  - 0003-4967 (Linking)
VI  - 69
IP  - 1
DP  - 2010 Jan
TI  - A new design for registration trials in rheumatoid arthritis allowing secondary
      head-to-head comparisons with standard of care treatment including biologicals.
PG  - 4-6
LID - 10.1136/ard.2009.110007 [doi]
AB  - Current drug development programs produce high quality data on the efficacy of
      new drugs, substantial data on safety, but little data on actual applicability of
      the new product compared to standard of care. After successful registration and
      launch, such data require years to accumulate and often remain incomplete. This
      viewpoint proposes a new trial design for phase 2 and 3 drug trials in rheumatoid
      arthritis. In this design the trial starts conventionally: patients that are
      inadequate responders to standard treatment (usually methotrexate) are randomised
      to receive the experimental drug or placebo on the background of continued
      (methotrexate) treatment. However, after 3 months all patients in the placebo
      group are additionally treated with one and the same standard of care treatment
      (usually an inhibitor of tumour necrosis factor) and all patients in the
      experimental group are additionally treated with a placebo corresponding to the
      chosen standard of care treatment. This design allows primary assessment of
      efficacy and safety of the experimental drug compared with placebo at the
      ethically acceptable limit of 3 months, followed by secondary assessments of
      efficacy (including durability) and safety compared to standard of care. The
      secondary assessments are observational and thus more prone to bias, but it is
      argued that the potential for bias is limited in this setting. Widespread
      adoption of the design will greatly help to determine the place of a new product 
      in the spectrum of treatment possibilities of rheumatoid arthritis.
FAU - Boers, Maarten
AU  - Boers M
AD  - Department of Epidemiology and Biostatistics, VU University Medical Center, PK 6Z
      165, PO Box 7057, 1007 MB Amsterdam, The Netherlands. eb@vumc.nl
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - England
TA  - Ann Rheum Dis
JT  - Annals of the rheumatic diseases
JID - 0372355
RN  - 0 (Antirheumatic Agents)
RN  - 0 (Immunologic Factors)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - YL5FZ2Y5U1 (Methotrexate)
SB  - IM
CON - Ann Rheum Dis. 2010 Jan;69(1):186-92. PMID: 19773287
CIN - Ann Rheum Dis. 2010 Jan;69(1):1-3. PMID: 20007619
MH  - Antirheumatic Agents/*therapeutic use
MH  - Arthritis, Rheumatoid/*drug therapy
MH  - Humans
MH  - Immunologic Factors/*therapeutic use
MH  - Methotrexate/therapeutic use
MH  - Randomized Controlled Trials as Topic/*methods
MH  - Research Design
MH  - Time Factors
MH  - Treatment Failure
MH  - Treatment Outcome
MH  - Tumor Necrosis Factor-alpha/antagonists & inhibitors
EDAT- 2009/12/17 06:00
MHDA- 2010/02/02 06:00
CRDT- 2009/12/17 06:00
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2010/02/02 06:00 [medline]
AID - 69/01/4 [pii]
AID - 10.1136/ard.2009.110007 [doi]
PST - ppublish
SO  - Ann Rheum Dis. 2010 Jan;69(1):4-6. doi: 10.1136/ard.2009.110007.


PMID- 20007619
OWN - NLM
STAT- MEDLINE
DCOM- 20100201
LR  - 20091216
IS  - 1468-2060 (Electronic)
IS  - 0003-4967 (Linking)
VI  - 69
IP  - 1
DP  - 2010 Jan
TI  - Clinical trials: how to cope with medical needs, ethics and timelines.
PG  - 1-3
LID - 10.1136/ard.2009.120733 [doi]
FAU - Rubbert-Roth, Andrea
AU  - Rubbert-Roth A
FAU - Burmester, Gerd-Rudiger
AU  - Burmester GR
LA  - eng
PT  - Comment
PT  - Editorial
PL  - England
TA  - Ann Rheum Dis
JT  - Annals of the rheumatic diseases
JID - 0372355
RN  - 0 (Antirheumatic Agents)
SB  - IM
CON - Ann Rheum Dis. 2010 Jan;69(1):186-92. PMID: 19773287
CON - Ann Rheum Dis. 2010 Jan;69(1):4-6. PMID: 20007620
MH  - Antirheumatic Agents/*therapeutic use
MH  - Arthritis, Rheumatoid/*drug therapy
MH  - Humans
MH  - Randomized Controlled Trials as Topic/ethics/*methods
MH  - Research Design
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2009/12/17 06:00
MHDA- 2010/02/02 06:00
CRDT- 2009/12/17 06:00
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2010/02/02 06:00 [medline]
AID - 69/01/1 [pii]
AID - 10.1136/ard.2009.120733 [doi]
PST - ppublish
SO  - Ann Rheum Dis. 2010 Jan;69(1):1-3. doi: 10.1136/ard.2009.120733.


PMID- 20007433
OWN - NLM
STAT- MEDLINE
DCOM- 20100308
LR  - 20220408
IS  - 1477-0970 (Electronic)
IS  - 1352-4585 (Linking)
VI  - 16
IP  - 1
DP  - 2010 Jan
TI  - 'Gimme five': future challenges in multiple sclerosis. ECTRIMS Lecture 2009.
PG  - 3-14
LID - 10.1177/1352458509357355 [doi]
AB  - This article is based on the ECTRIMS lecture given at the 25( th) ECTRIMS meeting
      which was held in Dusseldorf, Germany, from 9 to 12 September 2009. Five
      challenges have been identified: (1) safeguarding the principles of medical
      ethics; (2) optimizing the risk/benefit ratio; (3) bridging the gap between
      multiple sclerosis and experimental autoimmune encephalitis; (4) promoting
      neuroprotection and repair; and (5) tailoring multiple sclerosis therapy to the
      individual patient. Each of these challenges will be discussed and placed in the 
      context of current research into the pathogenesis and treatment of multiple
      sclerosis.
FAU - Hohlfeld, Reinhard
AU  - Hohlfeld R
AD  - Institute of Clinical Neuroimmunology, Ludwig Maximilians University of Munich,
      Munchen, Germany. reinhard.hohlfeld@med.uni-muenchen.de
LA  - eng
PT  - Lecture
DEP - 20091209
PL  - England
TA  - Mult Scler
JT  - Multiple sclerosis (Houndmills, Basingstoke, England)
JID - 9509185
RN  - 0 (Neuroprotective Agents)
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - Encephalomyelitis, Autoimmune, Experimental/genetics/therapy
MH  - Ethics, Medical
MH  - Europe
MH  - Genetic Engineering
MH  - Humans
MH  - Multiple Sclerosis/genetics/pathology/*therapy
MH  - Nervous System/pathology
MH  - Neuroprotective Agents/therapeutic use
MH  - Precision Medicine
MH  - Proteomics
MH  - Risk Assessment
EDAT- 2009/12/17 06:00
MHDA- 2010/03/10 06:00
CRDT- 2009/12/17 06:00
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2010/03/10 06:00 [medline]
AID - 1352458509357355 [pii]
AID - 10.1177/1352458509357355 [doi]
PST - ppublish
SO  - Mult Scler. 2010 Jan;16(1):3-14. doi: 10.1177/1352458509357355. Epub 2009 Dec 9.


PMID- 20006764
OWN - NLM
STAT- MEDLINE
DCOM- 20100217
LR  - 20141120
IS  - 1097-6833 (Electronic)
IS  - 0022-3476 (Linking)
VI  - 156
IP  - 1
DP  - 2010 Jan
TI  - An ethical and policy analysis of elective transplantation for metabolic
      conditions diagnosed by newborn screening.
PG  - 139-44
LID - 10.1016/j.jpeds.2009.06.067 [doi]
FAU - Ross, Lainie Friedman
AU  - Ross LF
AD  - Departments of Medicine, Pediatrics, Surgery and the College, MacLean Center for 
      Clinical Medical Ethics, University of Chicago, Chicago, IL 60637, USA.
      Lross@uchicago.edu
LA  - eng
PT  - Clinical Conference
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Pediatr
JT  - The Journal of pediatrics
JID - 0375410
RN  - 8LL8S712J7 (Methylmalonic Acid)
SB  - IM
MH  - Elective Surgical Procedures/*ethics
MH  - *Ethics, Clinical
MH  - Health Policy
MH  - Humans
MH  - Infant, Newborn
MH  - Liver Transplantation/*ethics
MH  - Maple Syrup Urine Disease/*surgery
MH  - Metabolism, Inborn Errors/*surgery
MH  - Methylmalonic Acid/*blood
MH  - *Neonatal Screening
EDAT- 2009/12/17 06:00
MHDA- 2010/02/18 06:00
CRDT- 2009/12/17 06:00
PHST- 2009/02/01 00:00 [received]
PHST- 2009/05/26 00:00 [revised]
PHST- 2009/06/30 00:00 [accepted]
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2010/02/18 06:00 [medline]
AID - S0022-3476(09)00636-2 [pii]
AID - 10.1016/j.jpeds.2009.06.067 [doi]
PST - ppublish
SO  - J Pediatr. 2010 Jan;156(1):139-44. doi: 10.1016/j.jpeds.2009.06.067.


PMID- 20006668
OWN - NLM
STAT- MEDLINE
DCOM- 20100409
LR  - 20100324
IS  - 1879-3185 (Electronic)
IS  - 0300-483X (Linking)
VI  - 269
IP  - 2-3
DP  - 2010 Mar 10
TI  - Medical surveillance, exposure registries, and epidemiologic research for workers
      exposed to nanomaterials.
PG  - 128-35
LID - 10.1016/j.tox.2009.12.006 [doi]
AB  - While there is a growing body of information about hazards of nanomaterials,
      little is known about the risks to workers exposed to them. However, workers are 
      the first people in society that are being exposed to the growing inventory of
      "nano-enabled" products in commerce. The number of workers involved in the
      investigation, manufacture, production, and disposal of these types of products
      is growing. Although toxicologic research is still the highest priority, it is
      time to actively anticipate the health needs of workers. To date, precautionary
      risk management approaches have been widely advocated. Now there is a need to
      initiate an evolving process to identify the issues in medical surveillance,
      utilization of exposure registries, and the conduct of epidemiologic research.
      Each of these are related complex endeavors that build on the toxicologic
      evidence and extent of exposure. There is a need to assess the scientific basis
      and research needs for determining early functional changes, organ system and
      disease responses for use in targeted medical surveillance. There is also need
      for development of criteria for extrapolating toxicological data in biological
      systems to predict the risk of adverse outcomes in humans. In the meantime,
      exposure registries may be pivotal in helping societies act in the face of
      uncertainty in a precautionary manner, but legal, ethical, and logistical issues 
      need resolution. Epidemiologic research will build on these efforts and may
      ultimately contribute critical definitive rationale for medical screening, risk
      assessment and management.
FAU - Trout, Douglas B
AU  - Trout DB
AD  - National Institute for Occupational Safety and Health, Centers for Disease
      Control and Prevention, 4676 Columbia Parkway, MS C-14, Cincinnati, OH 45226,
      USA.
FAU - Schulte, Paul A
AU  - Schulte PA
LA  - eng
PT  - Journal Article
DEP - 20091216
PL  - Ireland
TA  - Toxicology
JT  - Toxicology
JID - 0361055
RN  - 0 (Air Pollutants, Occupational)
SB  - IM
MH  - Air Pollutants, Occupational/*toxicity
MH  - Chemical Industry/standards
MH  - Humans
MH  - Inhalation Exposure/analysis
MH  - Nanostructures/*toxicity
MH  - Occupational Exposure/*analysis
MH  - *Registries
MH  - Research
MH  - Risk Assessment
MH  - Safety Management/standards
MH  - *Sentinel Surveillance
MH  - Toxicity Tests
EDAT- 2009/12/17 06:00
MHDA- 2010/04/10 06:00
CRDT- 2009/12/17 06:00
PHST- 2009/06/17 00:00 [received]
PHST- 2009/11/30 00:00 [revised]
PHST- 2009/12/07 00:00 [accepted]
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2010/04/10 06:00 [medline]
AID - S0300-483X(09)00610-6 [pii]
AID - 10.1016/j.tox.2009.12.006 [doi]
PST - ppublish
SO  - Toxicology. 2010 Mar 10;269(2-3):128-35. doi: 10.1016/j.tox.2009.12.006. Epub
      2009 Dec 16.


PMID- 20005888
OWN - NLM
STAT- MEDLINE
DCOM- 20100315
LR  - 20100222
IS  - 1096-0333 (Electronic)
IS  - 0041-008X (Linking)
VI  - 243
IP  - 2
DP  - 2010 Mar 1
TI  - Safety assessment of personal care products/cosmetics and their ingredients.
PG  - 239-59
LID - 10.1016/j.taap.2009.12.001 [doi]
AB  - We attempt to review the safety assessment of personal care products (PCP) and
      ingredients that are representative and pose complex safety issues. PCP are
      generally applied to human skin and mainly produce local exposure, although skin 
      penetration or use in the oral cavity, on the face, lips, eyes and mucosa may
      also produce human systemic exposure. In the EU, US and Japan, the safety of PCP 
      is regulated under cosmetic and/or drug regulations. Oxidative hair dyes contain 
      arylamines, the most chemically reactive ingredients of PCP. Although arylamines 
      have an allergic potential, taking into account the high number of consumers
      exposed, the incidence and prevalence of hair dye allergy appears to be low and
      stable. A recent (2001) epidemiology study suggested an association of oxidative 
      hair dye use and increased bladder cancer risk in consumers, although this was
      not confirmed by subsequent or previous epidemiologic investigations. The results
      of genetic toxicity, carcinogenicity and reproductive toxicity studies suggest
      that modern hair dyes and their ingredients pose no genotoxic, carcinogenic or
      reproductive risk. Recent reports suggest that arylamines contained in oxidative 
      hair dyes are N-acetylated in human or mammalian skin resulting in systemic
      exposure to traces of detoxified, i.e. non-genotoxic, metabolites, whereas human 
      hepatocytes were unable to transform hair dye arylamines to potentially
      carcinogenic metabolites. An expert panel of the International Agency on Research
      of Cancer (IARC) concluded that there is no evidence for a causal association of 
      hair dye exposure with an elevated cancer risk in consumers. Ultraviolet filters 
      have important benefits by protecting the consumer against adverse effects of UV 
      radiation; these substances undergo a stringent safety evaluation under current
      international regulations prior to their marketing. Concerns were also raised
      about the safety of solid nanoparticles in PCP, mainly TiO(2) and ZnO in
      sunscreens. However, current evidence suggests that these particles are
      non-toxic, do not penetrate into or through normal or compromised human skin and,
      therefore, pose no risk to human health. The increasing use of natural plant
      ingredients in personal care products raised new safety issues that require novel
      approaches to their safety evaluation similar to those of plant-derived food
      ingredients. For example, the Threshold of Toxicological Concern (TTC) is a
      promising tool to assess the safety of substances present at trace levels as well
      as minor ingredients of plant-derived substances. The potential human systemic
      exposure to PCP ingredients is increasingly estimated on the basis of in vitro
      skin penetration data. However, new evidence suggests that the in vitro test may 
      overestimate human systemic exposure to PCP ingredients due to the absence of
      metabolism in cadaver skin or misclassification of skin residues that, in vivo,
      remain in the stratum corneum or hair follicle openings, i.e. outside the living 
      skin. Overall, today's safety assessment of PCP and their ingredients is not only
      based on science, but also on their respective regulatory status as well as other
      issues, such as the ethics of animal testing. Nevertheless, the record shows that
      today's PCP are safe and offer multiple benefits to quality of life and health of
      the consumer. In the interest of all stakeholders, consumers, regulatory bodies
      and producers, there is an urgent need for an international harmonization on the 
      status and safety requirements of these products and their ingredients.
FAU - Nohynek, Gerhard J
AU  - Nohynek GJ
AD  - L'OREAL R&D, Global Safety Evaluation, 92600 Asnieres, France.
      gnohynec@rd.loreal.com <gnohynec@rd.loreal.com>
FAU - Antignac, Eric
AU  - Antignac E
FAU - Re, Thomas
AU  - Re T
FAU - Toutain, Herve
AU  - Toutain H
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20091221
PL  - United States
TA  - Toxicol Appl Pharmacol
JT  - Toxicology and applied pharmacology
JID - 0416575
RN  - 0 (Cosmetics)
RN  - 0 (Hair Dyes)
RN  - 0 (Sunscreening Agents)
SB  - IM
MH  - Animals
MH  - Consumer Product Safety
MH  - Cosmetics/*adverse effects/*toxicity
MH  - Hair Dyes/adverse effects/toxicity
MH  - Humans
MH  - Legislation, Drug
MH  - Plants/chemistry
MH  - Risk Assessment/methods
MH  - Safety
MH  - Sunscreening Agents/adverse effects/toxicity
RF  - 195
EDAT- 2009/12/17 06:00
MHDA- 2010/03/17 06:00
CRDT- 2009/12/17 06:00
PHST- 2009/10/28 00:00 [received]
PHST- 2009/11/27 00:00 [revised]
PHST- 2009/12/02 00:00 [accepted]
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2010/03/17 06:00 [medline]
AID - S0041-008X(09)00501-8 [pii]
AID - 10.1016/j.taap.2009.12.001 [doi]
PST - ppublish
SO  - Toxicol Appl Pharmacol. 2010 Mar 1;243(2):239-59. doi:
      10.1016/j.taap.2009.12.001. Epub 2009 Dec 21.


PMID- 20005588
OWN - NLM
STAT- MEDLINE
DCOM- 20100503
LR  - 20100217
IS  - 1879-1646 (Electronic)
IS  - 0167-6296 (Linking)
VI  - 29
IP  - 1
DP  - 2010 Jan
TI  - Physician incentives: cure versus prevention.
PG  - 124-36
LID - 10.1016/j.jhealeco.2009.11.006 [doi]
AB  - This paper distinguishes between two scenarios for the physician-patient
      encounter. In the cure scenario, the patient does not know whether a loss can be 
      recovered. In the prevention scenario, the patient faces a threat but does not
      know whether this threat is real enough to justify preventive action. The patient
      wants to induce the physician both to give an accurate diagnosis and to put
      appropriate effort into cure or prevention. It is shown that in the cure
      scenario, a contingent fee solves both these incentive problems. In the
      prevention scenario, however, putting up with low effort makes it easier to get
      an accurate diagnosis, and the use of contingent fees should be limited. These
      results are interpreted as providing a rationale for observed exceptions to legal
      and ethical restrictions on the use of contingent fees. Indeed, such exceptions
      are often granted for cases that fit the cure scenario.
CI  - Copyright 2009 Elsevier B.V. All rights reserved.
FAU - De Jaegher, Kris
AU  - De Jaegher K
AD  - Utrecht School of Economics, Utrecht University, Janskerkhof 12, 3512BL Utrecht, 
      The Netherlands. : k.dejaegher@uu.nl
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091214
PL  - Netherlands
TA  - J Health Econ
JT  - Journal of health economics
JID - 8410622
MH  - Humans
MH  - Models, Statistical
MH  - Negotiating
MH  - Netherlands
MH  - *Physician-Patient Relations
MH  - Physicians/*economics
MH  - Primary Prevention/*economics
MH  - *Reimbursement, Incentive
EDAT- 2009/12/17 06:00
MHDA- 2010/05/04 06:00
CRDT- 2009/12/17 06:00
PHST- 2008/10/13 00:00 [received]
PHST- 2009/08/03 00:00 [revised]
PHST- 2009/11/11 00:00 [accepted]
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2010/05/04 06:00 [medline]
AID - S0167-6296(09)00134-9 [pii]
AID - 10.1016/j.jhealeco.2009.11.006 [doi]
PST - ppublish
SO  - J Health Econ. 2010 Jan;29(1):124-36. doi: 10.1016/j.jhealeco.2009.11.006. Epub
      2009 Dec 14.


PMID- 20005569
OWN - NLM
STAT- MEDLINE
DCOM- 20100416
LR  - 20220330
IS  - 1878-5905 (Electronic)
IS  - 0142-9612 (Linking)
VI  - 31
IP  - 8
DP  - 2010 Mar
TI  - Adult cell therapy for brain neuronal damages and the role of tissue engineering.
PG  - 2105-20
LID - 10.1016/j.biomaterials.2009.11.084 [doi]
AB  - No long term effective treatments are currently available for brain neurological 
      disorders such as stroke/cerebral ischemia, traumatic brain injury and
      neurodegenerative disorders. Cell therapy is a promising strategy, although
      alternatives to embryonic/foetal cells are required to overcome ethical, tissue
      availability and graft rejection concerns. Adult cells may be easily isolated
      from the patient body, therefore permitting autologous grafts to be performed.
      Here, we describe the use of adult neural stem cells, adrenal chromaffin cells
      and retinal pigment epithelium cells for brain therapy, with a special emphasis
      on mesenchymal stromal cells. However, major problems like cell survival, control
      of differentiation and engraftment remain and may be overcome using a tissue
      engineering strategy, which provides a 3D support to grafted cells improving
      their survival. New developments, such as the biomimetic approach which combines 
      the use of scaffolds with extracellular matrix molecules, may improve the control
      of cell proliferation, survival, migration, differentiation and engraftment in
      vivo. Therefore, we later discuss scaffold properties required for brain cell
      therapy as well as new tissue engineering advances that may be implemented in
      combination with adult cells for brain therapy. Finally, we describe an approach 
      developed in our laboratory to repair/protect lesioned tissues: the
      pharmacologically active microcarriers.
CI  - Copyright (c) 2009 Elsevier Ltd. All rights reserved.
FAU - Delcroix, Gaetan J-R
AU  - Delcroix GJ
AD  - Inserm, U646, University Angers, UMR-S646, Angers, F49100 France.
FAU - Schiller, Paul C
AU  - Schiller PC
FAU - Benoit, Jean-Pierre
AU  - Benoit JP
FAU - Montero-Menei, Claudia N
AU  - Montero-Menei CN
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20091214
PL  - Netherlands
TA  - Biomaterials
JT  - Biomaterials
JID - 8100316
RN  - 0 (Biocompatible Materials)
SB  - IM
MH  - Adult Stem Cells/cytology/physiology
MH  - Animals
MH  - Biocompatible Materials/chemistry/metabolism
MH  - *Brain/cytology/pathology
MH  - Brain Injuries/pathology/therapy
MH  - Cell Culture Techniques
MH  - *Cell- and Tissue-Based Therapy
MH  - Cells, Cultured
MH  - Extracellular Matrix/chemistry/metabolism
MH  - Humans
MH  - Neurodegenerative Diseases/therapy
MH  - Neurons/*cytology/physiology
MH  - Stroke/therapy
MH  - *Tissue Engineering
MH  - Tissue Scaffolds
RF  - 204
EDAT- 2009/12/17 06:00
MHDA- 2010/04/17 06:00
CRDT- 2009/12/17 06:00
PHST- 2009/11/05 00:00 [received]
PHST- 2009/11/24 00:00 [accepted]
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2010/04/17 06:00 [medline]
AID - S0142-9612(09)01328-3 [pii]
AID - 10.1016/j.biomaterials.2009.11.084 [doi]
PST - ppublish
SO  - Biomaterials. 2010 Mar;31(8):2105-20. doi: 10.1016/j.biomaterials.2009.11.084.
      Epub 2009 Dec 14.


PMID- 20005067
OWN - NLM
STAT- MEDLINE
DCOM- 20110307
LR  - 20220331
IS  - 1873-5134 (Electronic)
IS  - 0738-3991 (Linking)
VI  - 78
IP  - 3
DP  - 2010 Mar
TI  - What constitutes evidence-based patient information? Overview of discussed
      criteria.
PG  - 316-28
LID - 10.1016/j.pec.2009.10.029 [doi]
AB  - OBJECTIVE: To survey quality criteria for evidence-based patient information
      (EBPI) and to compile the evidence for the identified criteria. METHODS:
      Databases PubMed, Cochrane Library, PsycINFO, PSYNDEX and Education Research
      Information Center (ERIC) were searched to update the pool of criteria for EBPI. 
      A subsequent search aimed to identify evidence for each criterion. Only studies
      on health issues with cognitive outcome measures were included. Evidence for each
      criterion is presented using descriptive methods. RESULTS: 3 systematic reviews, 
      24 randomized-controlled studies and 1 non-systematic review were included.
      Presentation of numerical data, verbal presentation of risks and diagrams,
      graphics and charts are based on good evidence. Content of information and
      meta-information, loss- and gain-framing and patient-oriented outcome measures
      are based on ethical guidelines. There is a lack of studies on quality of
      evidence, pictures and drawings, patient narratives, cultural aspects, layout,
      language and development process. CONCLUSION: The results of this review allow
      specification of EBPI and may help to advance the discourse among related
      disciplines. Research gaps are highlighted. PRACTICE IMPLICATIONS: Findings
      outline the type and extent of content of EBPI, guide the presentation of
      information and describe the development process.
CI  - Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
FAU - Bunge, Martina
AU  - Bunge M
AD  - University of Hamburg, Unit of Health Sciences and Education, 20146 Hamburg,
      Germany. Martina.Bunge@uni-hamburg.de
FAU - Muhlhauser, Ingrid
AU  - Muhlhauser I
FAU - Steckelberg, Anke
AU  - Steckelberg A
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20091214
PL  - Ireland
TA  - Patient Educ Couns
JT  - Patient education and counseling
JID - 8406280
MH  - Communication
MH  - Data Collection
MH  - Decision Making
MH  - *Evidence-Based Medicine
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Informed Consent
MH  - *Patient Education as Topic
MH  - Patient Participation
MH  - Physician-Patient Relations
MH  - *Referral and Consultation
RF  - 76
EDAT- 2009/12/17 06:00
MHDA- 2011/03/08 06:00
CRDT- 2009/12/17 06:00
PHST- 2009/04/30 00:00 [received]
PHST- 2009/10/07 00:00 [revised]
PHST- 2009/10/23 00:00 [accepted]
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2011/03/08 06:00 [medline]
AID - S0738-3991(09)00519-9 [pii]
AID - 10.1016/j.pec.2009.10.029 [doi]
PST - ppublish
SO  - Patient Educ Couns. 2010 Mar;78(3):316-28. doi: 10.1016/j.pec.2009.10.029. Epub
      2009 Dec 14.


PMID- 20004417
OWN - NLM
STAT- MEDLINE
DCOM- 20100714
LR  - 20100413
IS  - 1879-3363 (Electronic)
IS  - 0025-326X (Linking)
VI  - 60
IP  - 4
DP  - 2010 Apr
TI  - Using blood samples to estimate persistent organic pollutants and metals in green
      sea turtles (Chelonia mydas).
PG  - 579-88
LID - 10.1016/j.marpolbul.2009.11.006 [doi]
AB  - Persistent organic pollutants (POPs) and heavy metals have been reported in a
      number of green turtle (Chelonia mydas) populations worldwide. However, due to
      ethical considerations, these studies have generally been on tissues from
      deceased and stranded animals. The purpose of this study was to investigate the
      use of blood samples to estimate the tissue contamination of live C. mydas
      populations. This study analysed 125 POP compounds and eight heavy metals in the 
      blood, liver, kidney and muscle of 16 C. mydas from the Sea World Sea Turtle
      Rehabilitation Program, Gold Coast, Australia. Strong correlations were observed 
      between blood and tissue concentrations for a number of POPs and metals.
      Furthermore, these correlations were observed over large ranges of turtle size,
      sex and condition. These results indicate that blood samples are a reliable
      non-lethal method for predicting chemical contamination in C. mydas.
CI  - (c) 2009 Elsevier Ltd. All rights reserved.
FAU - van de Merwe, Jason P
AU  - van de Merwe JP
AD  - Griffith School of Environment and Australian Rivers Institute, Griffith
      University, Gold Coast, Queensland, Australia. jpvanders@hotmail.com
FAU - Hodge, Mary
AU  - Hodge M
FAU - Olszowy, Henry A
AU  - Olszowy HA
FAU - Whittier, Joan M
AU  - Whittier JM
FAU - Lee, Shing Y
AU  - Lee SY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091209
PL  - England
TA  - Mar Pollut Bull
JT  - Marine pollution bulletin
JID - 0260231
RN  - 0 (Metals)
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
MH  - Animals
MH  - Environmental Monitoring/methods
MH  - Kidney/chemistry
MH  - Liver/chemistry
MH  - Metals/*blood/chemistry
MH  - Muscle, Skeletal/chemistry
MH  - Turtles/*blood
MH  - Water Pollutants, Chemical/*blood/chemistry
EDAT- 2009/12/17 06:00
MHDA- 2010/07/16 06:00
CRDT- 2009/12/17 06:00
PHST- 2009/09/22 00:00 [received]
PHST- 2009/11/05 00:00 [revised]
PHST- 2009/11/07 00:00 [accepted]
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2010/07/16 06:00 [medline]
AID - S0025-326X(09)00467-6 [pii]
AID - 10.1016/j.marpolbul.2009.11.006 [doi]
PST - ppublish
SO  - Mar Pollut Bull. 2010 Apr;60(4):579-88. doi: 10.1016/j.marpolbul.2009.11.006.
      Epub 2009 Dec 9.


PMID- 20004228
OWN - NLM
STAT- MEDLINE
DCOM- 20100409
LR  - 20141120
IS  - 1879-3185 (Electronic)
IS  - 0300-483X (Linking)
VI  - 270
IP  - 1
DP  - 2010 Mar 30
TI  - Challenges of using pluripotent stem cells for safety assessments of substances.
PG  - 10-7
LID - 10.1016/j.tox.2009.12.003 [doi]
AB  - Various European Union (EU) legislations request the use of in vitro tests for
      toxicological evaluations in order to increase the safety of consumer and
      patients but also to reduce the number vertebrates. The review provides a brief
      overview on EU legislations in place but without further interpretation. At
      present several ongoing EU projects address the need of developing predictive in 
      vitro tests including projects assessing the potential of human embryonic stem
      cell (hESC) lines as basis for a range of toxicity tests. Tests based on human
      cells would avoid interspecies variations and as such predict more precisely
      adverse effects to the human body. However, the ethical situation on the use of
      toxicity tests based on hESCs is still under debate since no harmonization within
      Europe on the use of hESC lines has been achieved yet. A mutual acceptance of
      toxicity tests based on hESCs for regulatory applications is therefore
      challenging. Recent reports on the establishment of induced pluripotent stem
      cells (iPSC) are pointing to a way out of this dilemma, since these cells have
      apparently very similar characteristics as hESCs and could serve as basis for the
      development of toxicity tests. A careful scientific comparison between
      pluripotent cells of different origin is now needed in order to make final
      judgments. In any case, the development of reliable and relevant in vitro
      toxicity tests based on human pluripotent cells requires additional quality
      assessments of critical parameter that are also summarized within the review.
CI  - (c) 2009 Elsevier Ireland Ltd. All rights reserved.
FAU - Vojnits, Kinga
AU  - Vojnits K
AD  - European Joint Research Centre (JRC), Institute for Health and Consumer
      Protection (IHCP), In Vitro Methods/ECVAM, TP 580, Via E. Fermi No 2749, 21027
      Ispra, Italy.
FAU - Bremer, Susanne
AU  - Bremer S
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20091211
PL  - Ireland
TA  - Toxicology
JT  - Toxicology
JID - 0361055
RN  - 0 (Cosmetics)
SB  - IM
MH  - Animal Testing Alternatives
MH  - Animals
MH  - Cellular Reprogramming/genetics
MH  - Cosmetics/toxicity
MH  - Europe
MH  - Humans
MH  - Pluripotent Stem Cells/*drug effects
MH  - Quality Control
MH  - Safety
MH  - Toxicology/ethics/legislation & jurisprudence/*methods
RF  - 68
EDAT- 2009/12/17 06:00
MHDA- 2010/04/10 06:00
CRDT- 2009/12/17 06:00
PHST- 2009/05/25 00:00 [received]
PHST- 2009/12/03 00:00 [accepted]
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2010/04/10 06:00 [medline]
AID - S0300-483X(09)00607-6 [pii]
AID - 10.1016/j.tox.2009.12.003 [doi]
PST - ppublish
SO  - Toxicology. 2010 Mar 30;270(1):10-7. doi: 10.1016/j.tox.2009.12.003. Epub 2009
      Dec 11.


PMID- 20002618
OWN - NLM
STAT- MEDLINE
DCOM- 20100512
LR  - 20220309
IS  - 1365-3156 (Electronic)
IS  - 1360-2276 (Linking)
VI  - 15
IP  - 2
DP  - 2010 Feb
TI  - Research needs for an improved primary care response to chronic non-communicable 
      diseases in Africa.
PG  - 176-81
LID - 10.1111/j.1365-3156.2009.02438.x [doi]
AB  - With non-communicable diseases (NCDs) projected to become leading causes of
      morbidity and mortality in developing countries, research is needed to improve
      the primary care response, especially in sub-Saharan Africa. This region has a
      particularly high double burden of communicable diseases and NCDs and the least
      resources for an effective response. There is a lack of good quality
      epidemiological data from diverse settings on chronic NCD burden in sub-Saharan
      Africa, and the approach to primary care of people with chronic NCDs is currently
      often unstructured. The main primary care research needs are therefore firstly,
      epidemiological research to document the burden of chronic NCDs, and secondly,
      health system research to deliver the structured, programmatic, public health
      approach that has been proposed for the primary care of people with chronic NCDs.
      Documentation of the burden and trends of chronic NCDs and associated risk
      factors in different settings and different population groups is needed to enable
      health system planning for an improved primary care response. Key research issues
      in implementing the programmatic framework for an improved primary care response 
      are how to (i) integrate screening and prevention within health delivery; (ii)
      validate the use of standard diagnostic protocols for NCD case-finding among
      patients presenting to the local health facilities; (iii) improve the procurement
      and provision of standardised treatment and (iv) develop and implement a data
      collection system for standardised monitoring and evaluation of patient outcomes.
      Important research considerations include the following: selection of research
      sites and the particular NCDs targeted; research methodology; local research
      capacity; research collaborations; ethical issues; translating research findings 
      into policy and practice and funding. Meeting the research needs for an improved 
      health system response is crucial to deliver effective, affordable and equitable 
      care for the millions of people with chronic NCDs in developing countries in
      Africa.
FAU - Maher, D
AU  - Maher D
AD  - MRC/UVRI Uganda Research Unit on AIDS, Entebbe, Uganda.
      dermot.maher@mrcuganda.org
FAU - Sekajugo, J
AU  - Sekajugo J
FAU - Harries, A D
AU  - Harries AD
FAU - Grosskurth, H
AU  - Grosskurth H
LA  - eng
GR  - MC_U950080926/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091209
PL  - England
TA  - Trop Med Int Health
JT  - Tropical medicine & international health : TM & IH
JID - 9610576
SB  - IM
MH  - Africa South of the Sahara/epidemiology
MH  - Chronic Disease/epidemiology/*therapy
MH  - Delivery of Health Care/organization & administration
MH  - *Developing Countries
MH  - Diffusion of Innovation
MH  - Health Services Research/*methods
MH  - Humans
MH  - Primary Health Care/*organization & administration/standards
EDAT- 2009/12/17 06:00
MHDA- 2010/05/13 06:00
CRDT- 2009/12/17 06:00
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2010/05/13 06:00 [medline]
AID - TMI2438 [pii]
AID - 10.1111/j.1365-3156.2009.02438.x [doi]
PST - ppublish
SO  - Trop Med Int Health. 2010 Feb;15(2):176-81. doi:
      10.1111/j.1365-3156.2009.02438.x. Epub 2009 Dec 9.


PMID- 20002460
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20100507
IS  - 1399-0004 (Electronic)
IS  - 0009-9163 (Linking)
VI  - 77
IP  - 4
DP  - 2010 Apr
TI  - Experts' opinions on ethical issues of genetic research into Alzheimer's disease:
      results of a Delphi study in the Netherlands.
PG  - 382-8
LID - 10.1111/j.1399-0004.2009.01323.x [doi]
AB  - Most publications on the ethical aspects of genetic research into Alzheimer's
      Disease (AD) concentrate on the differences between the opinions of professionals
      and non-professionals. Differences in rating of morally relevant issues between
      groups of professionals have not yet been described. A modified Delphi study in
      two rounds was held to identify differences between groups of experts (i.e.
      clinicians, representatives of patient organisations, ethicists and persons with 
      a commercial background). The strongest correlation was found between the
      opinions of ethicists and representatives of patient organisations (0.67) and
      between clinicians and ethicists (0.62). Moderate correlation (0.55) was found
      between the opinions of clinicians and representatives of patient organisations. 
      Persons with a commercial background showed a weak correlation with clinicians
      (0.41), ethicists (0.35) and representatives of patient organisations (0.30).
      These differences in rating of morally relevant issues between various
      professional groups are relevant for clinical practice and dementia care,
      particularly the different rating of prenatal diagnosis found between clinicians 
      and representatives of patient organisations. Interdisciplinary consultations
      between various professional groups -including at least researchers, clinicians
      and ethicists -are recommended to guarantee that all considerations will be
      incorporated into the debate on ethical issues of genetic research into AD.
FAU - van der Vorm, A
AU  - van der Vorm A
AD  - IQ Healthcare, Section of Ethics, Philosophy and History of Medicine, Radboud
      University Nijmegen Medical Centre, Nijmegen, The Netherlands.
      a.vandervorm@iq.umcn.nl
FAU - van der Laan, A L
AU  - van der Laan AL
FAU - Borm, G
AU  - Borm G
FAU - Vernooij-Dassen, M
AU  - Vernooij-Dassen M
FAU - Olde Rikkert, M
AU  - Olde Rikkert M
FAU - van Leeuwen, E
AU  - van Leeuwen E
FAU - Dekkers, W
AU  - Dekkers W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091210
PL  - Denmark
TA  - Clin Genet
JT  - Clinical genetics
JID - 0253664
SB  - IM
MH  - Alzheimer Disease/*genetics
MH  - *Delphi Technique
MH  - Expert Testimony/*ethics
MH  - Genetic Research/*ethics
MH  - Humans
MH  - Netherlands
EDAT- 2009/12/17 06:00
MHDA- 2010/09/15 06:00
CRDT- 2009/12/17 06:00
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2010/09/15 06:00 [medline]
AID - CGE1323 [pii]
AID - 10.1111/j.1399-0004.2009.01323.x [doi]
PST - ppublish
SO  - Clin Genet. 2010 Apr;77(4):382-8. doi: 10.1111/j.1399-0004.2009.01323.x. Epub
      2009 Dec 10.


PMID- 20002110
OWN - NLM
STAT- MEDLINE
DCOM- 20100913
LR  - 20100723
IS  - 1469-8749 (Electronic)
IS  - 0012-1622 (Linking)
VI  - 52
IP  - 3
DP  - 2010 Mar
TI  - Statistical recommendations for papers submitted to Developmental Medicine &
      Child Neurology.
PG  - 299-304
LID - 10.1111/j.1469-8749.2009.03553.x [doi]
AB  - The use of statistics in medical diagnoses and biomedical research may affect
      whether an individual may live or die, whether their health is protected or
      jeopardized. Because society depends on sound statistical practice, all
      practitioners of statistics, whatever their training or occupation, have social
      obligations to perform their work in a professional, competent, and ethical
      manner.
FAU - Rigby, Alan S
AU  - Rigby AS
AD  - Academic Cardiology and Hull York Medical School, University of Hull,
      Kingston-upon-Hull, Hull, UK. asr1960@hotmail.com
LA  - eng
PT  - Journal Article
DEP - 20100204
PL  - England
TA  - Dev Med Child Neurol
JT  - Developmental medicine and child neurology
JID - 0006761
SB  - IM
MH  - Child
MH  - *Child Development
MH  - *Data Interpretation, Statistical
MH  - Ethics, Professional
MH  - *Guidelines as Topic
MH  - Humans
MH  - Neurology/*statistics & numerical data
MH  - Professional Competence
MH  - Publishing/*standards/*statistics & numerical data
MH  - Social Responsibility
EDAT- 2009/12/17 06:00
MHDA- 2010/09/14 06:00
CRDT- 2009/12/17 06:00
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2010/09/14 06:00 [medline]
AID - DMCN3553 [pii]
AID - 10.1111/j.1469-8749.2009.03553.x [doi]
PST - ppublish
SO  - Dev Med Child Neurol. 2010 Mar;52(3):299-304. doi:
      10.1111/j.1469-8749.2009.03553.x. Epub 2010 Feb 4.


PMID- 19998372
OWN - NLM
STAT- MEDLINE
DCOM- 20100301
LR  - 20211203
IS  - 1549-4918 (Electronic)
IS  - 1066-5099 (Linking)
VI  - 28
IP  - 1
DP  - 2010 Jan
TI  - Law, ethics, religion, and clinical translation in the 21st century.
PG  - 2
LID - 10.1002/stem.272 [doi]
FAU - Trounson, Alan
AU  - Trounson A
AD  - California Institute for Regenerative Medicine, 210 King Street San Francisco, CA
      94107, USA. info@cirm.ca.gov
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Portrait
PL  - England
TA  - Stem Cells
JT  - Stem cells (Dayton, Ohio)
JID - 9304532
SB  - IM
MH  - Embryonic Stem Cells/*transplantation
MH  - History, 21st Century
MH  - Humans
MH  - Morals
MH  - Pluripotent Stem Cells/*transplantation
MH  - Public Opinion
MH  - *Religion and Medicine
MH  - *Stem Cell Transplantation/ethics/legislation & jurisprudence
MH  - *Translational Research, Biomedical/ethics/legislation & jurisprudence
EDAT- 2009/12/10 06:00
MHDA- 2010/03/02 06:00
CRDT- 2009/12/10 06:00
PHST- 2009/12/10 06:00 [entrez]
PHST- 2009/12/10 06:00 [pubmed]
PHST- 2010/03/02 06:00 [medline]
AID - 10.1002/stem.272 [doi]
PST - ppublish
SO  - Stem Cells. 2010 Jan;28(1):2. doi: 10.1002/stem.272.


PMID- 19998371
OWN - NLM
STAT- MEDLINE
DCOM- 20100301
LR  - 20211203
IS  - 1549-4918 (Electronic)
IS  - 1066-5099 (Linking)
VI  - 28
IP  - 1
DP  - 2010 Jan
TI  - Law, ethics, religion, and clinical translation in the 21st century--a discussion
      with John Sinden.
PG  - 3-4
LID - 10.1002/stem.273 [doi]
FAU - Lako, Majlinda
AU  - Lako M
FAU - Trounson, Alan
AU  - Trounson A
FAU - Daher, Susan
AU  - Daher S
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Portrait
PL  - England
TA  - Stem Cells
JT  - Stem cells (Dayton, Ohio)
JID - 9304532
SB  - IM
MH  - Adult Stem Cells/*transplantation
MH  - History, 21st Century
MH  - Humans
MH  - Morals
MH  - Pluripotent Stem Cells/*transplantation
MH  - Public Opinion
MH  - *Religion and Medicine
MH  - *Stem Cell Transplantation/ethics/legislation & jurisprudence
MH  - *Translational Research, Biomedical/ethics/legislation & jurisprudence
EDAT- 2009/12/10 06:00
MHDA- 2010/03/02 06:00
CRDT- 2009/12/10 06:00
PHST- 2009/12/10 06:00 [entrez]
PHST- 2009/12/10 06:00 [pubmed]
PHST- 2010/03/02 06:00 [medline]
AID - 10.1002/stem.273 [doi]
PST - ppublish
SO  - Stem Cells. 2010 Jan;28(1):3-4. doi: 10.1002/stem.273.


PMID- 19998023
OWN - NLM
STAT- MEDLINE
DCOM- 20100816
LR  - 20211020
IS  - 1433-3023 (Electronic)
IS  - 0937-3462 (Linking)
VI  - 21
IP  - 6
DP  - 2010 Jun
TI  - Iliosacral bacterial arthritis and retroperitoneal abscess after tension-free
      vaginal mesh reconstruction.
PG  - 753-5
LID - 10.1007/s00192-009-1063-y [doi]
AB  - A 64-year-old woman presented with severe infection accompanied by iliosacral
      arthritis and retroperitoneal abscess after tension-free vaginal mesh
      reconstruction using polypropylene meshes (GyneMesh; Gynecare, Ethicon,
      Somerville, NJ, USA) for pelvic organ prolapsed quantification of stage 3 pelvic 
      organ prolapse. Three weeks after the operation, she complained of high fever (39
      degrees C) and sharp pain from the left buttock down to the left lower limb.
      Computed tomography revealed a retroperitoneal abscess and osteolysis caused by
      iliosacral arthritis. Because the infection was not resolved by drainage and
      antibiotic therapy, the left portion of the mesh was removed. She recovered after
      mesh removal, and no recurrent abscess was observed in the CT after a 6-month
      follow-up. However, the patient complained of sporadic discomfort in the left
      buttock, and a blood examination performed during this period, revealed a slight 
      elevation in the C-reactive protein level. Although this symptom was resolved by 
      oral antibiotics, further follow-up was required.
FAU - Chien, Hung-wu
AU  - Chien HW
AD  - The Tazuke Kofukai Medical Research Institution, Kitano Hospital, 2-4-20
      Ohgimachi, Kita-ku, Osaka 530-8480, Japan.
FAU - Kumakura, Erika
AU  - Kumakura E
FAU - Koyama, Masayasu
AU  - Koyama M
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20091209
PL  - England
TA  - Int Urogynecol J
JT  - International urogynecology journal
JID - 101567041
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Polypropylenes)
RN  - 6Q205EH1VU (Vancomycin)
SB  - IM
MH  - Anti-Bacterial Agents/therapeutic use
MH  - Arthritis, Infectious/drug therapy/*etiology/microbiology
MH  - Female
MH  - Humans
MH  - *Methicillin-Resistant Staphylococcus aureus/isolation & purification
MH  - Middle Aged
MH  - Osteomyelitis/etiology/microbiology
MH  - Pelvic Organ Prolapse/surgery
MH  - Polypropylenes/*adverse effects
MH  - Retropharyngeal Abscess/drug therapy/*etiology/microbiology
MH  - Sacroiliac Joint/diagnostic imaging/microbiology
MH  - Sacrum/microbiology
MH  - Staphylococcal Infections/drug therapy/*etiology
MH  - Suburethral Slings/*adverse effects
MH  - Tomography, X-Ray Computed
MH  - Vancomycin/therapeutic use
EDAT- 2009/12/10 06:00
MHDA- 2010/08/17 06:00
CRDT- 2009/12/10 06:00
PHST- 2009/08/10 00:00 [received]
PHST- 2009/11/19 00:00 [accepted]
PHST- 2009/12/10 06:00 [entrez]
PHST- 2009/12/10 06:00 [pubmed]
PHST- 2010/08/17 06:00 [medline]
AID - 10.1007/s00192-009-1063-y [doi]
PST - ppublish
SO  - Int Urogynecol J. 2010 Jun;21(6):753-5. doi: 10.1007/s00192-009-1063-y. Epub 2009
      Dec 9.


PMID- 19997084
OWN - NLM
STAT- MEDLINE
DCOM- 20100614
LR  - 20211203
IS  - 1473-1150 (Electronic)
IS  - 1470-269X (Linking)
VI  - 10
IP  - 2
DP  - 2010 Apr
TI  - Ethical considerations in the collection of genetic data from critically ill
      patients: what do published studies reveal about potential directions for
      empirical ethics research?
PG  - 77-85
LID - 10.1038/tpj.2009.61 [doi]
AB  - Critical illness trials involving genetic data collection are increasingly
      commonplace and pose challenges not encountered in less acute settings, related
      in part to the precipitous, severe and incapacitating nature of the diseases
      involved. We performed a systematic literature review to understand the nature of
      such studies conducted to date, and to consider, from an ethical perspective,
      potential barriers to future investigations. We identified 79 trials enrolling 24
      499 subjects. Median (interquartile range) number of participants per study was
      263 (116.75-430.75). Of these individuals, 16 269 (66.4%) were Caucasian, 1327
      (5.4%) were African American, 1707 (7.0%) were Asian Pacific Islanders and 139
      (0.6%) were Latino. For 5020 participants (20.5%), ethnicity was not reported.
      Forty-eight studies (60.8%) recruited subjects from single centers and all
      studies examined a relatively small number of genetic markers. Technological
      advances have rendered it feasible to conduct clinical studies using high-density
      genome-wide scanning. It will be necessary for future critical illness trials
      using these approaches to be of greater scope and complexity than those so far
      reported. Empirical research into issues related to greater ethnic inclusivity,
      accuracy of substituted judgment and specimen stewardship may be essential for
      enabling the conduct of such trials.
FAU - Freeman, B D
AU  - Freeman BD
AD  - Department of Surgery, Washington University School of Medicine, St Louis, MO
      63110, USA. freemanb@wustl.edu
FAU - Kennedy, C R
AU  - Kennedy CR
FAU - Frankel, H L
AU  - Frankel HL
FAU - Clarridge, B
AU  - Clarridge B
FAU - Bolcic-Jankovic, D
AU  - Bolcic-Jankovic D
FAU - Iverson, E
AU  - Iverson E
FAU - Shehane, E
AU  - Shehane E
FAU - Celious, A
AU  - Celious A
FAU - Zehnbauer, B A
AU  - Zehnbauer BA
FAU - Buchman, T G
AU  - Buchman TG
LA  - eng
GR  - R01 GM080591/GM/NIGMS NIH HHS/United States
GR  - R01 GM080591-02/GM/NIGMS NIH HHS/United States
GR  - GM080591/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20091208
PL  - United States
TA  - Pharmacogenomics J
JT  - The pharmacogenomics journal
JID - 101083949
SB  - IM
MH  - Adult
MH  - African Americans
MH  - Asian Americans
MH  - Biomedical Research/*ethics
MH  - *Critical Illness
MH  - *Genetic Variation
MH  - Hispanic or Latino
MH  - Humans
MH  - Informed Consent/ethics
MH  - Multiple Organ Failure/ethnology/*genetics
MH  - Patient Selection/*ethics
MH  - Randomized Controlled Trials as Topic/*ethics
MH  - Sepsis/ethnology/*genetics
MH  - Shock, Septic/ethnology/*genetics
MH  - Whites
PMC - PMC2860600
MID - NIHMS195907
EDAT- 2009/12/10 06:00
MHDA- 2010/06/15 06:00
CRDT- 2009/12/10 06:00
PHST- 2009/12/10 06:00 [entrez]
PHST- 2009/12/10 06:00 [pubmed]
PHST- 2010/06/15 06:00 [medline]
AID - tpj200961 [pii]
AID - 10.1038/tpj.2009.61 [doi]
PST - ppublish
SO  - Pharmacogenomics J. 2010 Apr;10(2):77-85. doi: 10.1038/tpj.2009.61. Epub 2009 Dec
      8.


PMID- 19996934
OWN - NLM
STAT- MEDLINE
DCOM- 20100430
LR  - 20220310
IS  - 1550-5014 (Electronic)
IS  - 0161-9268 (Linking)
VI  - 33
IP  - 1
DP  - 2010 Jan-Mar
TI  - Fundamental patterns of knowing in nursing: the challenge of evidence-based
      practice.
PG  - 3-14
LID - 10.1097/ANS.0b013e3181c9d5eb [doi]
AB  - This article reconsiders the fundamental patterns of knowing in nursing in light 
      of the challenge of narrow empirics in the form of evidence-based practice.
      Objections to the dominance of evidence-based practice are reviewed, and the
      reasons for it are examined. It is argued that it is partially the result of
      weaknesses in the alternative patterns of ethical, personal, and esthetic
      knowing, the ineffability of which compromises accountability. This ineffability 
      can be countered only by introducing a wider form of empirics than countenanced
      by evidence-based practice into all patterns of knowing, to demonstrate their
      salience and to make their use in practice transparent.
FAU - Porter, Sam
AU  - Porter S
AD  - School of Nursing and Midwifery, Queen's University Belfast, Northern Ireland,
      United Kingdom. s.porter@qub.ac.uk
LA  - eng
PT  - Journal Article
PL  - United States
TA  - ANS Adv Nurs Sci
JT  - ANS. Advances in nursing science
JID - 7809992
SB  - IM
MH  - Empathy
MH  - Empirical Research
MH  - Esthetics
MH  - Evidence-Based Nursing/ethics/*organization & administration
MH  - Humans
MH  - *Knowledge
MH  - *Models, Nursing
MH  - Nurse's Role/psychology
MH  - Nurse-Patient Relations
MH  - Nursing Process/ethics/*organization & administration
MH  - Nursing Research/*organization & administration
MH  - Philosophy, Nursing
MH  - Postmodernism
MH  - Research Design
MH  - Science
EDAT- 2009/12/10 06:00
MHDA- 2010/05/01 06:00
CRDT- 2009/12/10 06:00
PHST- 2009/12/10 06:00 [entrez]
PHST- 2009/12/10 06:00 [pubmed]
PHST- 2010/05/01 06:00 [medline]
AID - 10.1097/ANS.0b013e3181c9d5eb [doi]
PST - ppublish
SO  - ANS Adv Nurs Sci. 2010 Jan-Mar;33(1):3-14. doi: 10.1097/ANS.0b013e3181c9d5eb.


PMID- 19968805
OWN - NLM
STAT- MEDLINE
DCOM- 20100325
LR  - 20151119
IS  - 1460-9592 (Electronic)
IS  - 1155-5645 (Linking)
VI  - 20
IP  - 1
DP  - 2010 Jan
TI  - Changes in acid-base, electrolyte and hemoglobin concentrations during infusion
      of hydroxyethyl starch 130/0.42/6 : 1 in normal saline or in balanced electrolyte
      solution in children.
PG  - 100-4
LID - 10.1111/j.1460-9592.2009.03197.x [doi]
AB  - INTRODUCTION: A balanced volume replacement strategy is a well established
      concept for correcting hypovolemia using plasma adapted isotonic crystalloid
      solutions with a physiological electrolyte pattern and acetate as bicarbonate
      precursor. Recently, third-generation hydroxyethyl starch (HES) has also become
      available in a balanced electrolyte solution instead of normal saline. Therefore,
      in this prospective non-interventional clinical study, the perioperative
      administration of HES 130/0.42/6 : 1 in normal saline (ns-HES) and in balanced
      electrolyte solution (bal-HES) was evaluated in children with a focus on
      acid-base, electrolyte and hemoglobin changes. METHODS: Following local ethics
      committee approval, pediatric patients aged up to 12 years with an ASA risk score
      of I-III undergoing perioperative administration of HES (ns-HES from May 2006 to 
      December 2007, bal-HES from January 2008 to January 2009) were included. Patient 
      demographics, the performed procedure, adverse drug reactions, hemodynamic data
      and the results of blood gas analysis were documented with a focus on changes in 
      acid-base, electrolyte and hemoglobin concentrations. RESULTS: Of 396 enrolled
      patients (ASA I-III; age 2.3 +/- 3, range day of birth - 12 years; body weight
      10.8 +/- 9, range 0.9-52 kg), 249 received ns-HES and 147 bal-HES (mean volume
      infused 9.9 +/- 4 and 9.4 +/- 6.9 ml x kg(-1), respectively). After HES infusion,
      hemoglobin decreased in both groups, whereas bicarbonate and base excess (BE)
      decreased only with ns-HES and remained stable with bal-HES (BE before infusion: 
      ns-HES -1.8 +/- 2.8, bal-HES -1.7 +/- 2.7 mmol x l(-1); after infusion: ns-HES
      -2.6 +/- 2.4; bal-HES -1.6 +/- 2.6 mmol x l(-1), P < 0.05). Chloride (Cl)
      concentrations increased in both groups and were significantly higher with ns-HES
      (Cl before infusion: ns-HES 105.6 +/- 3.7, bal-HES 105.1 +/- 2.8 mmol x l(-1);
      after infusion: ns-HES 107.7 +/- 3.2, bal-HES 106.3 +/- 2.9 mmol x l(-1), P <
      0.01). No serious adverse drug reactions were observed. CONCLUSION: Infusion
      related iatrogenic acid-base and electrolyte alterations can be minimized by
      using hydroxyethyl starch in a balanced electrolyte solution instead of normal
      saline.
FAU - Sumpelmann, Robert
AU  - Sumpelmann R
AD  - Medizinische Hochschule Hannover, Klinik fur Anasthesiologie und
      Intensivmedizin-OE 8050, Hanover, Germany. suempelmann.robert@mh-hannover.de
FAU - Witt, Lars
AU  - Witt L
FAU - Brutt, Meike
AU  - Brutt M
FAU - Osterkorn, Dirk
AU  - Osterkorn D
FAU - Koppert, Wolfgang
AU  - Koppert W
FAU - Osthaus, Wilhelm A
AU  - Osthaus WA
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20091123
PL  - France
TA  - Paediatr Anaesth
JT  - Paediatric anaesthesia
JID - 9206575
RN  - 0 (Electrolytes)
RN  - 0 (Hemoglobins)
RN  - 0 (Hydroxyethyl Starch Derivatives)
RN  - 0 (Pharmaceutical Solutions)
RN  - 0 (Plasma Substitutes)
RN  - 451W47IQ8X (Sodium Chloride)
SB  - IM
MH  - Acid-Base Equilibrium/*drug effects
MH  - Acid-Base Imbalance/prevention & control
MH  - Aging/physiology
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Electrolytes/*blood
MH  - Female
MH  - Hemoglobins/*metabolism
MH  - Humans
MH  - Hydroxyethyl Starch Derivatives/administration & dosage/*adverse effects
MH  - Infant
MH  - Male
MH  - Pharmaceutical Solutions
MH  - Plasma Substitutes/administration & dosage/*adverse effects
MH  - Prospective Studies
MH  - Sodium Chloride
MH  - Surgical Procedures, Operative
EDAT- 2009/12/09 06:00
MHDA- 2010/03/26 06:00
CRDT- 2009/12/09 06:00
PHST- 2009/12/09 06:00 [entrez]
PHST- 2009/12/09 06:00 [pubmed]
PHST- 2010/03/26 06:00 [medline]
AID - PAN3197 [pii]
AID - 10.1111/j.1460-9592.2009.03197.x [doi]
PST - ppublish
SO  - Paediatr Anaesth. 2010 Jan;20(1):100-4. doi: 10.1111/j.1460-9592.2009.03197.x.
      Epub 2009 Nov 23.


PMID- 19967525
OWN - NLM
STAT- MEDLINE
DCOM- 20100222
LR  - 20091207
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Linking)
VI  - 598
DP  - 2010
TI  - Fundamentals of clinical immunotoxicology.
PG  - 363-84
LID - 10.1007/978-1-60761-401-2_24 [doi]
AB  - Whereas animal studies are invaluable for screening various chemical and drugs
      for immunotoxic potential, such systems are necessarily limited in their
      predictive value for humans given the differences in physiology, immune system
      structure and function, and various other parameters between humans and nonhuman 
      animals. However, prospective experimental studies in humans are not always
      practical or ethical. What is needed is an approach for combining animal data,
      human data collected in the course of clinical studies, and modern tools of
      bioinformatics and systems biology. In this chapter, we will explore current
      assays and methodologies for assessing immunotoxic potential in humans using this
      multi--parameter approach.
FAU - House, Robert V
AU  - House RV
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
RN  - 0 (Antibodies)
RN  - 0 (Autoantibodies)
RN  - 0 (Cytokines)
RN  - 0 (Immunologic Factors)
RN  - 0 (Vaccines)
SB  - IM
MH  - Animals
MH  - Antibodies/immunology
MH  - Autoantibodies/immunology
MH  - Autoimmunity/physiology
MH  - Computational Biology
MH  - Cytokines/immunology
MH  - Drug Evaluation, Preclinical
MH  - Humans
MH  - Hypersensitivity, Delayed/immunology
MH  - Immunologic Factors/*immunology
MH  - Immunologic Tests/*methods
MH  - Killer Cells, Natural/immunology
MH  - Risk Assessment
MH  - Toxicity Tests/*methods
MH  - Vaccines/adverse effects/immunology
EDAT- 2009/12/08 06:00
MHDA- 2010/02/23 06:00
CRDT- 2009/12/08 06:00
PHST- 2009/12/08 06:00 [entrez]
PHST- 2009/12/08 06:00 [pubmed]
PHST- 2010/02/23 06:00 [medline]
AID - 10.1007/978-1-60761-401-2_24 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2010;598:363-84. doi: 10.1007/978-1-60761-401-2_24.


PMID- 19965950
OWN - NLM
STAT- MEDLINE
DCOM- 20100810
LR  - 20100302
IS  - 1477-030X (Electronic)
IS  - 0269-2163 (Linking)
VI  - 24
IP  - 2
DP  - 2010 Mar
TI  - Review: a narrative review of the published ethical debates in palliative care
      research and an assessment of their adequacy to inform research governance.
PG  - 111-26
LID - 10.1177/0269216309352714 [doi]
AB  - The quality of research, and the resulting quality of evidence available to guide
      palliative care, is dependent on the ethical decisions underpinning its design,
      conduct and report. Whilst much has been published debating the ethics of
      palliative care research, an assessment of the quality and synthesis of the
      central debates is not available. Such a review is timely to inform research
      governance. The methodology of this study is based on the principles of
      systematic reviews. Fifty-seven papers were reviewed following a thorough search,
      and were critically appraised for their literary quality, the knowledge on which 
      they drew and the research standards they addressed. The debates identified
      address vulnerability, moral appropriateness, consent, gate-keeping and inclusion
      and research culture. The quality of debate and the sources of knowledge varied. 
      The debate was rich in quality and knowledge with respect to the protection of
      the dignity, rights and safety of research participants, but less developed in
      relation to those of researchers and other staff. There is also little debate
      about the ethics of reporting of research and the ethics underpinning research
      leadership. A framework is offered that reconciles the ethical issues raised with
      potential methodological strategies identified from the review.
FAU - Duke, Sue
AU  - Duke S
AD  - University of Southampton, Southampton, UK. sd11@soton.ac.uk
FAU - Bennett, Helen
AU  - Bennett H
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20091204
PL  - England
TA  - Palliat Med
JT  - Palliative medicine
JID - 8704926
SB  - IM
MH  - Confidentiality/*ethics
MH  - Humans
MH  - Informed Consent/*ethics
MH  - National Health Programs/legislation & jurisprudence
MH  - Palliative Care/*ethics/standards
MH  - Research/*standards
RF  - 69
EDAT- 2009/12/08 06:00
MHDA- 2010/08/11 06:00
CRDT- 2009/12/08 06:00
PHST- 2009/12/08 06:00 [entrez]
PHST- 2009/12/08 06:00 [pubmed]
PHST- 2010/08/11 06:00 [medline]
AID - 0269216309352714 [pii]
AID - 10.1177/0269216309352714 [doi]
PST - ppublish
SO  - Palliat Med. 2010 Mar;24(2):111-26. doi: 10.1177/0269216309352714. Epub 2009 Dec 
      4.


PMID- 19965570
OWN - NLM
STAT- MEDLINE
DCOM- 20100111
LR  - 20211020
IS  - 1541-0048 (Electronic)
IS  - 0090-0036 (Linking)
VI  - 100
IP  - 1
DP  - 2010 Jan
TI  - Health capability: conceptualization and operationalization.
PG  - 41-9
LID - 10.2105/AJPH.2008.143651 [doi]
AB  - Current theoretical approaches to bioethics and public health ethics propose
      varied justifications as the basis for health care and public health, yet none
      captures a fundamental reality: people seek good health and the ability to pursue
      it. Existing models do not effectively address these twin goals. The approach I
      espouse captures both of these orientations through a concept here called health 
      capability. Conceptually, health capability illuminates the conditions that
      affect health and one's ability to make health choices. By respecting the health 
      consequences individuals face and their health agency, health capability offers
      promise for finding a balance between paternalism and autonomy. I offer a
      conceptual model of health capability and present a health capability profile to 
      identify and address health capability gaps.
FAU - Ruger, Jennifer Prah
AU  - Ruger JP
AD  - Yale University School of Public Health, 60 College St, PO Box 208034, New Haven,
      CT 06520-8034, USA. jennifer.ruger@yale.edu
LA  - eng
GR  - K01 DA016358/DA/NIDA NIH HHS/United States
GR  - K01 DA016358-05/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Public Health
JT  - American journal of public health
JID - 1254074
SB  - IM
CIN - Am J Public Health. 2010 Oct;100(10):1823-4; author reply 1824. PMID: 20724670
MH  - *Attitude to Health
MH  - Delivery of Health Care/ethics/*organization & administration
MH  - Health Services Accessibility/*ethics
MH  - Healthcare Disparities/ethics
MH  - Humans
MH  - Models, Theoretical
MH  - Public Health/ethics
PMC - PMC2791246
MID - NIHMS211860
EDAT- 2009/12/08 06:00
MHDA- 2010/01/12 06:00
CRDT- 2009/12/08 06:00
PHST- 2009/12/08 06:00 [entrez]
PHST- 2009/12/08 06:00 [pubmed]
PHST- 2010/01/12 06:00 [medline]
AID - AJPH.2008.143651 [pii]
AID - 10.2105/AJPH.2008.143651 [doi]
PST - ppublish
SO  - Am J Public Health. 2010 Jan;100(1):41-9. doi: 10.2105/AJPH.2008.143651.


PMID- 19963332
OWN - NLM
STAT- MEDLINE
DCOM- 20101101
LR  - 20100706
IS  - 1873-5134 (Electronic)
IS  - 0738-3991 (Linking)
VI  - 80
IP  - 2
DP  - 2010 Aug
TI  - Assessing the impact of a modified informed consent process in a South African
      HIV/AIDS research trial.
PG  - 191-9
LID - 10.1016/j.pec.2009.10.019 [doi]
AB  - OBJECTIVE: The process of informed consent may be jeopardized in cross-linguistic
      research trials but little is known about the factors which contribute to this.
      The present study was designed to assess the impact on the understanding of trial
      participants of the essential components of a trial, as well as on the
      perceptions of the participants, through enrollment via a standard versus a
      modified informed consent protocol. METHODS: Counselors from two HIV trial sites 
      in South Africa were trained to enroll patients for a trial, using a modified
      informed consent protocol. The standard and modified protocols were compared.
      RESULTS: Marked differences were noted in effectiveness of the process after
      training using the modified protocol, resulting in improved patient
      understanding. An item analysis suggested those areas of the trial which were
      most difficult for counselors to communicate effectively and highlighted
      potential barriers and facilitators to the process. CONCLUSIONS: Cultural and
      linguistic modifications to the informed consent process can enhance the
      understanding of components of a research trial and are viewed as largely
      positive by the participants. PRACTICE IMPLICATIONS: Some implications for future
      enrollments, for developing policy and for the role of a language specialist on
      research ethics committees and in trial design are highlighted.
CI  - Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
FAU - Penn, Claire
AU  - Penn C
AD  - University of Witwatersrand, South Africa. Claire.penn@wits.ac.za
FAU - Evans, Melanie
AU  - Evans M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20091206
PL  - Ireland
TA  - Patient Educ Couns
JT  - Patient education and counseling
JID - 8406280
RN  - 0 (Anti-HIV Agents)
MH  - Anti-HIV Agents/supply & distribution/therapeutic use
MH  - Biomedical Research/ethics
MH  - Clinical Trials as Topic/*ethics
MH  - Communication
MH  - *Comprehension
MH  - Ethics Committees, Research
MH  - HIV Infections/drug therapy
MH  - Humans
MH  - Informed Consent/*ethics/standards
MH  - Language
MH  - South Africa
EDAT- 2009/12/08 06:00
MHDA- 2010/11/03 06:00
CRDT- 2009/12/08 06:00
PHST- 2009/01/26 00:00 [received]
PHST- 2009/10/05 00:00 [revised]
PHST- 2009/10/16 00:00 [accepted]
PHST- 2009/12/08 06:00 [entrez]
PHST- 2009/12/08 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - S0738-3991(09)00509-6 [pii]
AID - 10.1016/j.pec.2009.10.019 [doi]
PST - ppublish
SO  - Patient Educ Couns. 2010 Aug;80(2):191-9. doi: 10.1016/j.pec.2009.10.019. Epub
      2009 Dec 6.


PMID- 19963239
OWN - NLM
STAT- MEDLINE
DCOM- 20100405
LR  - 20100309
IS  - 1527-9995 (Electronic)
IS  - 0090-4295 (Linking)
VI  - 75
IP  - 3
DP  - 2010 Mar
TI  - Stem cells: a review and implications for urology.
PG  - 664-70
LID - 10.1016/j.urology.2009.03.058 [doi]
AB  - OBJECTIVE: The promise of stem cells is to provide a source of non-diseased
      material for the generation of patient-specific cells or tissue for replacement
      and reconstruction. This review will provide a broad perspective on stem cell
      research, from the sentinel discoveries to recent developments, and also discuss 
      translational implications. METHODS: We performed internet-based Pubmed database 
      searches to identify recent articles and review papers pertaining to stem cell
      research and urologic applications. RESULTS: Depending on their source, stem
      cells have a varied capacity to self-renew and divide and to differentiate into a
      desired phenotype. Pluripotent stem cells can potentially be differentiated into 
      any cell type and multipotent stem cells are variably lineage restricted. In the 
      urologic literature, stem cell derived smooth muscles have been produced and may 
      be useful for tissue-engineered constructs. CONCLUSIONS: The future of
      reconstructive surgery will surely incorporate a number of these stem cell based 
      technologies in revolutionary ways that may improve and extend lives. However,
      the ultimate utility and clinical applicability of the different types of stem
      cells will depend on a complex synthesis of further basic research, future
      clinical trials, and ethical and regulatory reconcilement.
CI  - 2010 Elsevier Inc. All rights reserved.
FAU - Yu, Richard N
AU  - Yu RN
AD  - Department of Urology, Children's Hospital Boston, Boston, Massachusetts 02115,
      USA.
FAU - Estrada, Carlos R
AU  - Estrada CR
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20091205
PL  - United States
TA  - Urology
JT  - Urology
JID - 0366151
SB  - IM
CIN - Urology. 2010 Mar;75(3):670; author reply 670-1. PMID: 20211376
MH  - Animals
MH  - Biomedical Research
MH  - Forecasting
MH  - Humans
MH  - Multipotent Stem Cells
MH  - Pluripotent Stem Cells
MH  - Stem Cell Transplantation
MH  - *Stem Cells
MH  - Urologic Diseases/*surgery
MH  - Urology/trends
RF  - 50
EDAT- 2009/12/08 06:00
MHDA- 2010/04/07 06:00
CRDT- 2009/12/08 06:00
PHST- 2008/11/21 00:00 [received]
PHST- 2009/03/11 00:00 [revised]
PHST- 2009/03/25 00:00 [accepted]
PHST- 2009/12/08 06:00 [entrez]
PHST- 2009/12/08 06:00 [pubmed]
PHST- 2010/04/07 06:00 [medline]
AID - S0090-4295(09)00936-4 [pii]
AID - 10.1016/j.urology.2009.03.058 [doi]
PST - ppublish
SO  - Urology. 2010 Mar;75(3):664-70. doi: 10.1016/j.urology.2009.03.058. Epub 2009 Dec
      5.


PMID- 19962241
OWN - NLM
STAT- MEDLINE
DCOM- 20100407
LR  - 20210112
IS  - 1872-6623 (Electronic)
IS  - 0304-3959 (Linking)
VI  - 148
IP  - 1
DP  - 2010 Jan
TI  - Placebo control--still the most ethical study design.
PG  - 174-175
LID - 10.1016/j.pain.2009.11.013 [doi]
FAU - Kvarstein, Gunnvald
AU  - Kvarstein G
AD  - Department of Anesthesiology and Intensive Care, Section of Pain Management, Oslo
      University Hospital, Rikshospitalet, Norway Hospital for Rehabilitation, Stavern,
      Vestfold Hospital Trust, Norway The Interventional Centre, Oslo University
      Hospital, Rikshospitalet, Norway Department of Radiology, Oslo University
      Hospital, Rikshospitalet, Norway Oslo University Hospital, Rikshospitalet and
      Faculty of Medicine, University of Oslo, Norway.
FAU - Mawe, Leif
AU  - Mawe L
FAU - Indahl, Aage
AU  - Indahl A
FAU - Hol, Per Kristian
AU  - Hol PK
FAU - Tennoe, Bjorn
AU  - Tennoe B
FAU - Digernes, Randi
AU  - Digernes R
FAU - Tonnessen, Tor Inge
AU  - Tonnessen TI
FAU - Beivik, Harald
AU  - Beivik H
FAU - Stubhaug, Audun
AU  - Stubhaug A
LA  - eng
PT  - Comment
PT  - Letter
DEP - 20091203
PL  - United States
TA  - Pain
JT  - Pain
JID - 7508686
RN  - 0 (Placebos)
SB  - IM
CON - Pain. 2009 Oct;145(3):265-6. PMID: 19683389
MH  - Humans
MH  - *Placebos
MH  - Randomized Controlled Trials as Topic/*ethics/methods
MH  - *Research Design
EDAT- 2009/12/08 06:00
MHDA- 2010/04/08 06:00
CRDT- 2009/12/08 06:00
PHST- 2009/11/05 00:00 [received]
PHST- 2009/11/10 00:00 [accepted]
PHST- 2009/12/08 06:00 [entrez]
PHST- 2009/12/08 06:00 [pubmed]
PHST- 2010/04/08 06:00 [medline]
AID - 00006396-201001000-00027 [pii]
AID - 10.1016/j.pain.2009.11.013 [doi]
PST - ppublish
SO  - Pain. 2010 Jan;148(1):174-175. doi: 10.1016/j.pain.2009.11.013. Epub 2009 Dec 3.


PMID- 19960547
OWN - NLM
STAT- MEDLINE
DCOM- 20100510
LR  - 20101213
IS  - 1099-0798 (Electronic)
IS  - 0735-3936 (Linking)
VI  - 28
IP  - 1
DP  - 2010 Jan-Feb
TI  - Legal, ethical, and methodological considerations in the Internet-based study of 
      child pornography offenders.
PG  - 84-105
LID - 10.1002/bsl.906 [doi]
AB  - With its ever-growing penetration of remote regions of the world, the Internet
      provides great opportunity for conducting research. Beyond clear advantages such 
      as increased cost-effectiveness and efficiency in collecting large samples,
      Internet-based research has proven particularly useful in reaching hidden or
      marginalized populations who engage in illegal or deviant behaviors. However,
      this new medium for research raises important and complex legal, ethical, and
      methodological/technological issues that researchers must address, particularly
      when studying undetected criminal behaviors. The current paper chronicles various
      issues that were encountered in the implementation of an active Internet-based
      pilot research study of child pornography (CP) users. Moreover, this study was
      undertaken to address a critical gap in the existing research on CP offending,
      which has to date primarily focused on incarcerated or convicted samples. The
      Internet provides the optimal medium for studying community populations of CP
      users, given that it has become the primary market for CP distribution. This
      paper is designed to serve as a guide for researchers interested in conducting
      Internet-based research studies on criminal and sexually deviant populations,
      particularly CP offenders. Several recommendations are offered based on our own
      experiences in the implementation of this study.
CI  - Copyright 2009 John Wiley & Sons, Ltd.
FAU - Ray, James V
AU  - Ray JV
AD  - University of South Florida, Tampa, FL 33612, USA.
FAU - Kimonis, Eva R
AU  - Kimonis ER
FAU - Donoghue, Christine
AU  - Donoghue C
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Behav Sci Law
JT  - Behavioral sciences & the law
JID - 8404861
SB  - IM
MH  - Child
MH  - Data Collection/methods
MH  - *Erotica/legislation & jurisprudence
MH  - *Ethics, Research
MH  - Humans
MH  - Informed Consent
MH  - *Internet/ethics/legislation & jurisprudence
MH  - Patient Selection
MH  - *Pedophilia
MH  - Privacy
MH  - *Sex Offenses/ethics/legislation & jurisprudence
EDAT- 2009/12/05 06:00
MHDA- 2010/05/11 06:00
CRDT- 2009/12/05 06:00
PHST- 2009/12/05 06:00 [entrez]
PHST- 2009/12/05 06:00 [pubmed]
PHST- 2010/05/11 06:00 [medline]
AID - 10.1002/bsl.906 [doi]
PST - ppublish
SO  - Behav Sci Law. 2010 Jan-Feb;28(1):84-105. doi: 10.1002/bsl.906.


PMID- 19959408
OWN - NLM
STAT- MEDLINE
DCOM- 20100610
LR  - 20220316
IS  - 1878-0539 (Electronic)
IS  - 1748-6815 (Linking)
VI  - 63
IP  - 6
DP  - 2010 Jun
TI  - Patients' perception of medical photography.
PG  - e507-11
LID - 10.1016/j.bjps.2009.11.005 [doi]
AB  - INTRODUCTION: With the advent of digital medical photography, a balance between
      technological possibility and ethical acceptability is necessary. An
      understanding of patients' perception is vital in maintaining a healthy
      doctor-patient relationship and the avoidance of unnecessary medico-legal
      consequences. To explore this, an anonymous patient questionnaire survey was
      conducted. METHODS: Ethically approved questionnaires were distributed in our
      plastic surgery clinics. The questionnaires examine patients' acceptability of
      the use of identifiable and non-identifiable photography for different purposes
      including teaching, presentation, publication and internet. Patients' preferences
      on equipment used and who should view their images were also recorded. 205
      completed questionnaires were analysed and statistically assessed. RESULTS: There
      was a low level of acceptability to the use of personal cameras (16%) and phones 
      (12%) compared to hospital equipment (75% p<0.001). The use of non-identifiable
      photographs was more acceptable for all purposes (p<0.001). Electronic
      distribution was less favoured (p<0.001). Patients agreed to have their
      photographs used by treating doctors (98%), other doctors (74%), for student
      teaching (82%) or patient education (88%). CONCLUSION: Medical photography is
      acceptable to most patients. Appropriate consent and equipment would maximise
      patient compliance and clinical benefits. Our discussion with medical
      professional and defence organisation provide a portrait of current perspectives.
CI  - Copyright 2009 British Association of Plastic, Reconstructive and Aesthetic
      Surgeons. Published by Elsevier Ltd. All rights reserved.
FAU - Lau, Catherine K
AU  - Lau CK
AD  - Department of Plastic and Reconstructive Surgery, Addenbrooke's Hospital,
      Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
      christylau8@doctors.org.uk
FAU - Schumacher, Hagen H A
AU  - Schumacher HH
FAU - Irwin, Michael S
AU  - Irwin MS
LA  - eng
PT  - Journal Article
DEP - 20091202
PL  - Netherlands
TA  - J Plast Reconstr Aesthet Surg
JT  - Journal of plastic, reconstructive & aesthetic surgery : JPRAS
JID - 101264239
SB  - IM
MH  - Access to Information/*psychology
MH  - Attitude
MH  - *Audiovisual Aids
MH  - Confidentiality/psychology
MH  - Education, Medical
MH  - Humans
MH  - Informed Consent/*psychology
MH  - Internet
MH  - Patient Education as Topic
MH  - Patient Preference/*psychology
MH  - *Photography
MH  - Reconstructive Surgical Procedures/education/*psychology
MH  - Surveys and Questionnaires
EDAT- 2009/12/05 06:00
MHDA- 2010/06/11 06:00
CRDT- 2009/12/05 06:00
PHST- 2009/08/05 00:00 [received]
PHST- 2009/10/24 00:00 [revised]
PHST- 2009/11/07 00:00 [accepted]
PHST- 2009/12/05 06:00 [entrez]
PHST- 2009/12/05 06:00 [pubmed]
PHST- 2010/06/11 06:00 [medline]
AID - S1748-6815(09)00780-3 [pii]
AID - 10.1016/j.bjps.2009.11.005 [doi]
PST - ppublish
SO  - J Plast Reconstr Aesthet Surg. 2010 Jun;63(6):e507-11. doi:
      10.1016/j.bjps.2009.11.005. Epub 2009 Dec 2.


PMID- 19959319
OWN - NLM
STAT- MEDLINE
DCOM- 20110210
LR  - 20220331
IS  - 0736-4679 (Print)
IS  - 0736-4679 (Linking)
VI  - 39
IP  - 5
DP  - 2010 Nov
TI  - Developing a standardized faculty evaluation in an emergency medicine residency.
PG  - 662-8
LID - 10.1016/j.jemermed.2009.09.001 [doi]
AB  - BACKGROUND: Quality educators are a core component of successful residency
      training. A structured, consistent, validated evaluation of clinical educators is
      important to improve teaching aptitude, further faculty development, and improve 
      patient care. STUDY OBJECTIVES: The authors sought to identify specific domains
      of instructional quality and to develop a composite instrument for assessing
      instructional quality. METHODS: The study setting is a 3-year residency program. 
      Residents rated the quality of faculty member instruction using an 18-item survey
      twice over a 2-year period (2004-2005). Each survey item used a 9-point scale.
      Factor analysis employing a Varimax rotation identified domains of instructional 
      performance. Cronbach's alpha was used to assess the internal consistency of the 
      identified domains. RESULTS: There were 29 faculty members evaluated. Using 2004 
      data, five domains of instructional quality were identified that explained 92.5% 
      of the variation in survey responses (chi(2) = 2.33, P = 0.11). These were:
      Competency and Professionalism (30% of variation), Commitment to Knowledge and
      Instruction (23%), Inclusion and Interaction (17%), Patient Focus (13%), and
      Openness to Ideas (9%). Competency and Professionalism included appropriate care,
      effective patient communication, use of new techniques, and ethical principles.
      Commitment to Knowledge and Instruction included research, mentoring, feedback,
      and availability. Inclusion and Interaction included procedural participation and
      bedside teaching. Patient Focus included compassion, effective care, and
      sensitivity to diverse populations. Openness to Ideas included enthusiasm and
      receptivity of new ideas. These five domains were consistent in the 2005 data
      (Cronbach's alpha 0.68-0.75). CONCLUSIONS: A five-domain instrument consistently 
      accounted for variations in faculty teaching performance as rated by resident
      physicians. This instrument may be useful for standardized assessment of
      instructional quality.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Colletti, James E
AU  - Colletti JE
AD  - Department of Emergency Medicine, Mayo Clinic College of Medicine, Rochester,
      Minnesota 55905, USA.
FAU - Flottemesch, Thomas J
AU  - Flottemesch TJ
FAU - O'Connell, Tara A
AU  - O'Connell TA
FAU - Ankel, Felix K
AU  - Ankel FK
FAU - Asplin, Brent R
AU  - Asplin BR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091203
PL  - United States
TA  - J Emerg Med
JT  - The Journal of emergency medicine
JID - 8412174
SB  - IM
MH  - Emergency Medicine/*education
MH  - Factor Analysis, Statistical
MH  - Faculty, Medical/*standards
MH  - Humans
MH  - *Internship and Residency/organization & administration
MH  - Leadership
EDAT- 2009/12/05 06:00
MHDA- 2011/02/11 06:00
CRDT- 2009/12/05 06:00
PHST- 2009/06/09 00:00 [received]
PHST- 2009/08/28 00:00 [revised]
PHST- 2009/09/06 00:00 [accepted]
PHST- 2009/12/05 06:00 [entrez]
PHST- 2009/12/05 06:00 [pubmed]
PHST- 2011/02/11 06:00 [medline]
AID - S0736-4679(09)00775-6 [pii]
AID - 10.1016/j.jemermed.2009.09.001 [doi]
PST - ppublish
SO  - J Emerg Med. 2010 Nov;39(5):662-8. doi: 10.1016/j.jemermed.2009.09.001. Epub 2009
      Dec 3.


PMID- 19957020
OWN - NLM
STAT- MEDLINE
DCOM- 20100517
LR  - 20211020
IS  - 1573-7284 (Electronic)
IS  - 0393-2990 (Linking)
VI  - 25
IP  - 2
DP  - 2010 Feb
TI  - Changing defaults in biobank research could save lives too.
PG  - 65-8
LID - 10.1007/s10654-009-9413-0 [doi]
AB  - In an effort to increase the amount of organs available for transplantation, many
      countries have implemented presumed consent for organ donation. Presuming a wish 
      to contribute to medical advances through biobank research on previously taken
      tissue samples could similarly improve health and wellbeing. In this article we
      analyze common arguments for and against presumed consent for organ donation and 
      assess their relevance in the context of biobank research. In spite of obvious
      differences between biobank research and organ transplantation the cases for
      implementing presumption of a positive attitude appear quite analogous. It has
      repeatedly been shown that a majority of the general population supports these
      projects and selecting informed consent as the default position decreases the
      amount of organs and samples available and thus reduces the prospect of promoting
      health. We conclude that instead of presuming that individuals do not wish to
      contribute to the advancement of healthcare through biobank research on
      previously taken samples, ethics committees should presume that they do.
FAU - Forsberg, Joanna Stjernschantz
AU  - Forsberg JS
AD  - Centre for Research Ethics and Bioethics, Uppsala University, Uppsala, Sweden.
      joanna.forsberg@crb.uu.se
FAU - Eriksson, Stefan
AU  - Eriksson S
FAU - Hansson, Mats G
AU  - Hansson MG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091203
PL  - Netherlands
TA  - Eur J Epidemiol
JT  - European journal of epidemiology
JID - 8508062
SB  - IM
MH  - Humans
MH  - Informed Consent
MH  - Presumed Consent/*ethics
MH  - Research
MH  - Tissue Banks/ethics
MH  - Tissue and Organ Procurement/*ethics
EDAT- 2009/12/04 06:00
MHDA- 2010/05/18 06:00
CRDT- 2009/12/04 06:00
PHST- 2009/09/08 00:00 [received]
PHST- 2009/11/24 00:00 [accepted]
PHST- 2009/12/04 06:00 [entrez]
PHST- 2009/12/04 06:00 [pubmed]
PHST- 2010/05/18 06:00 [medline]
AID - 10.1007/s10654-009-9413-0 [doi]
PST - ppublish
SO  - Eur J Epidemiol. 2010 Feb;25(2):65-8. doi: 10.1007/s10654-009-9413-0. Epub 2009
      Dec 3.


PMID- 19954911
OWN - NLM
STAT- MEDLINE
DCOM- 20101206
LR  - 20100813
IS  - 1872-7727 (Electronic)
IS  - 0720-048X (Linking)
VI  - 75
IP  - 2
DP  - 2010 Aug
TI  - Value of ductal obstruction sign in the differentiation of benign and malignant
      breast lesions at MR imaging.
PG  - e18-21
LID - 10.1016/j.ejrad.2009.10.032 [doi]
AB  - PURPOSE: MR-Mammography (MRM) is regarded as the most sensitive method for
      detection of breast cancer without a broad consensus on specificity. There is
      room for improvement of the existing ACR BIRADS lexicon by adding new and
      specific descriptors. Dilated ducts have been described in association with
      papillomas. However, the differential diagnostic value of this finding has not
      been investigated yet. MATERIALS AND METHODS: 316 consecutive patients,
      undergoing histopathologic workup after MR-Mammography were included in this
      prospective, ethical review board approved study. Two blinded radiologists rated 
      the images in consensus. Ductal obstruction was defined as dilated liquid filled 
      ducts proximal an enhancing lesion. Sensitivity, specificity as well as positive 
      and negative likelihood ratio (LR+, LR-) were calculated. RESULTS: Dilated ducts 
      were found in 60 cases (19%), 20 of these showed an association with enhancing
      lesions and were categorized as ductal obstruction (6.3%). Malignancy was found
      in two cases (one invasive ductal carcinoma and one DCIS) and benign tissue in 18
      cases (15 papillomas). The difference of ductal obstruction between these groups 
      was found to be highly significant in two-sided Fisher's exact test (p<0.001).
      Because of the clear association with benign lesions, benign lesions showing
      ductal obstruction were characterized as true positive findings. Therefore,
      following diagnostic parameters were calculated: sensitivity 15.4%, specificity
      99.0%, LR+ 15.3, LR- 0.9. DISCUSSION: If ductal obstruction is found to be
      positive, the associated lesion is most likely benign. Therefore, though a rare
      finding, this descriptor should be taken into account for improved lesion
      differentiation.
CI  - Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
FAU - Baltzer, P A T
AU  - Baltzer PA
AD  - Institute of Diagnostic and Interventional Radiology,
      Friedrich-Schiller-University Jena, Erlanger Allee 101, D-07740 Jena, Germany.
      pascal.baltzer@med.uni-jena.de
FAU - Kaiser, C G N
AU  - Kaiser CG
FAU - Dietzel, M
AU  - Dietzel M
FAU - Vag, T
AU  - Vag T
FAU - Herzog, A B
AU  - Herzog AB
FAU - Gajda, M
AU  - Gajda M
FAU - Camara, O
AU  - Camara O
FAU - Kaiser, W A
AU  - Kaiser WA
LA  - eng
PT  - Journal Article
DEP - 20091201
PL  - Ireland
TA  - Eur J Radiol
JT  - European journal of radiology
JID - 8106411
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged, 80 and over
MH  - Breast/pathology
MH  - Breast Diseases/diagnosis
MH  - Breast Neoplasms/*diagnosis
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Mammary Glands, Human/*pathology
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Sensitivity and Specificity
MH  - Young Adult
EDAT- 2009/12/04 06:00
MHDA- 2010/12/14 06:00
CRDT- 2009/12/04 06:00
PHST- 2009/10/28 00:00 [received]
PHST- 2009/10/29 00:00 [accepted]
PHST- 2009/12/04 06:00 [entrez]
PHST- 2009/12/04 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S0720-048X(09)00613-5 [pii]
AID - 10.1016/j.ejrad.2009.10.032 [doi]
PST - ppublish
SO  - Eur J Radiol. 2010 Aug;75(2):e18-21. doi: 10.1016/j.ejrad.2009.10.032. Epub 2009 
      Dec 1.


PMID- 19953124
OWN - NLM
STAT- MEDLINE
DCOM- 20100715
LR  - 20211020
IS  - 1476-5438 (Electronic)
IS  - 1018-4813 (Linking)
VI  - 18
IP  - 5
DP  - 2010 May
TI  - Legal and ethical consequences of international biobanking from a national
      perspective: the German BMB-EUCoop project.
PG  - 522-5
LID - 10.1038/ejhg.2009.214 [doi]
AB  - The international transfer of human biomaterial and data has become a
      prerequisite for collaborative biomedical research to be successful. However,
      although a national legal framework for 'biobanking' has already been formulated 
      in many countries, little is known about how an international exchange of data
      and samples might affect the legal position of national biobanks and their
      donors. The German Telematics Platform and the Competence Network 'Congenital
      Heart Defects' jointly instigated a project (BMB-EUCoop) to (i) identify and
      assess the legal risks ensuing for biobanks and their donors in the context of
      Europe-wide research collaborations, (ii) devise practical recommendations to
      minimize or avoid these risks, and (iii) provide generic informational text,
      contracts and agreements to facilitate their practical implementation. Four
      different countries were included in the study; namely, the UK, Netherlands,
      Austria and Switzerland. The results of the study indicate that the degree of
      similarity between legal systems in different countries varies according to the
      respective field of jurisdiction. Although personality and property rights have
      long been enshrined in virtually identical pieces of law, the applicable medical 
      professional regulations were found to be somewhat heterogeneous. Furthermore,
      clear-cut differences were often found to be lacking between regulations that
      reflect either 'soft law' or the nationally binding 'hard law' that has emerged
      from it. In view of the potential ambiguities, the experts uniformly concluded
      that the rights and interests of national (in this case, German) biobanks and
      their donors would be best protected by explicitly addressing any uncertainties
      in formal contractual agreements.
FAU - Goebel, Jurgen W
AU  - Goebel JW
AD  - RAe Goebel & Scheller, Bad Homburg, Germany.
FAU - Pickardt, Thomas
AU  - Pickardt T
FAU - Bedau, Maren
AU  - Bedau M
FAU - Fuchs, Michael
AU  - Fuchs M
FAU - Lenk, Christian
AU  - Lenk C
FAU - Paster, Inga
AU  - Paster I
FAU - Spranger, Tarde M
AU  - Spranger TM
FAU - Stockter, Ulrich
AU  - Stockter U
FAU - Bauer, Ulrike
AU  - Bauer U
FAU - Cooper, David N
AU  - Cooper DN
FAU - Krawczak, Michael
AU  - Krawczak M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091202
PL  - England
TA  - Eur J Hum Genet
JT  - European journal of human genetics : EJHG
JID - 9302235
SB  - IM
MH  - Germany
MH  - Humans
MH  - International Cooperation/*legislation & jurisprudence
MH  - Ownership/ethics/legislation & jurisprudence
MH  - Tissue Banks/*ethics/*legislation & jurisprudence
PMC - PMC2987313
EDAT- 2009/12/03 06:00
MHDA- 2010/07/16 06:00
CRDT- 2009/12/03 06:00
PHST- 2009/12/03 06:00 [entrez]
PHST- 2009/12/03 06:00 [pubmed]
PHST- 2010/07/16 06:00 [medline]
AID - ejhg2009214 [pii]
AID - 10.1038/ejhg.2009.214 [doi]
PST - ppublish
SO  - Eur J Hum Genet. 2010 May;18(5):522-5. doi: 10.1038/ejhg.2009.214. Epub 2009 Dec 
      2.


PMID- 19953123
OWN - NLM
STAT- MEDLINE
DCOM- 20100518
LR  - 20220309
IS  - 1476-5438 (Electronic)
IS  - 1018-4813 (Linking)
VI  - 18
IP  - 3
DP  - 2010 Mar
TI  - Non-invasive prenatal testing: ethical issues explored.
PG  - 272-7
LID - 10.1038/ejhg.2009.203 [doi]
AB  - This paper explores the ethical implications of introducing non-invasive prenatal
      diagnostic tests (NIPD tests) in prenatal screening for foetal abnormalities.
      NIPD tests are easy and safe and can be performed early in pregnancy. Precisely
      because of these features, it is feared that informed consent may become more
      difficult, that both testing and selective abortion will become 'normalized', and
      that there will be a trend towards accepting testing for minor abnormalities and 
      non-medical traits as well. In our view, however, the real moral challenge of
      NIPD testing consists in the possibility of linking up a technique with these
      features (easy, safe and early) with new genomic technologies that allow prenatal
      diagnostic testing for a much broader range of abnormalities than is the case in 
      current procedures. An increase in uptake and more selective abortions need not
      in itself be taken to signal a thoughtless acceptance of these procedures.
      However, combining this with considerably enlarging the scope of NIPD testing
      will indeed make informed consent more difficult and challenge the notion of
      prenatal screening as serving reproductive autonomy. If broad NIPD testing
      includes later-onset diseases, the 'right not to know' of the future child will
      become a new issue in the debate about prenatal screening. With regard to the
      controversial issue of selective abortion, it may make a morally relevant
      difference that after NIPD testing, abortion can be done early. A lower moral
      status may be attributed to the foetus at that moment, given the dominant opinion
      that the moral status of the foetus progressively increases with its development.
FAU - de Jong, Antina
AU  - de Jong A
AD  - Department of Health, Ethics and Society, Faculty of Health, Medicine and Life
      Sciences, Research Institute GROW, Maastricht University, Maastricht, The
      Netherlands. at.dejong@hes.unimaas.nl
FAU - Dondorp, Wybo J
AU  - Dondorp WJ
FAU - de Die-Smulders, Christine E M
AU  - de Die-Smulders CE
FAU - Frints, Suzanne G M
AU  - Frints SG
FAU - de Wert, Guido M W R
AU  - de Wert GM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091202
PL  - England
TA  - Eur J Hum Genet
JT  - European journal of human genetics : EJHG
JID - 9302235
SB  - IM
MH  - Abortion, Eugenic/ethics
MH  - *Ethics, Medical
MH  - Female
MH  - Humans
MH  - Informed Consent/ethics
MH  - Pregnancy
MH  - Prenatal Diagnosis/*ethics
PMC - PMC2987207
EDAT- 2009/12/03 06:00
MHDA- 2010/05/19 06:00
CRDT- 2009/12/03 06:00
PHST- 2009/12/03 06:00 [entrez]
PHST- 2009/12/03 06:00 [pubmed]
PHST- 2010/05/19 06:00 [medline]
AID - ejhg2009203 [pii]
AID - 10.1038/ejhg.2009.203 [doi]
PST - ppublish
SO  - Eur J Hum Genet. 2010 Mar;18(3):272-7. doi: 10.1038/ejhg.2009.203. Epub 2009 Dec 
      2.


PMID- 19952951
OWN - NLM
STAT- MEDLINE
DCOM- 20100302
LR  - 20091224
IS  - 1537-4513 (Electronic)
IS  - 1524-9557 (Linking)
VI  - 33
IP  - 1
DP  - 2010 Jan
TI  - Clinical expansion of cord blood-derived T cells for use as donor lymphocyte
      infusion after cord blood transplantation.
PG  - 96-105
LID - 10.1097/CJI.0b013e3181b291a4 [doi]
AB  - Allogeneic stem cell transplantation (SCT) from cord blood (CB) as a stem cell
      source is a promising alternative when no human leukocyte antigen-matched donor
      is found. Donor lymphocyte infusion (DLI) is a possible treatment modality for
      threatening graft failure or relapse of an underlying malignancy after
      transplantation. Ethical and logistical reasons limit the possibility of DLI in
      the setting of CB SCT. To remedy this restriction, we performed expansion of
      donor T cells in vitro from CB grafts in a clinical setting for use as future DLI
      and characterized the expanded cells in comparison to T cells from CB acquired ex
      vivo and adult peripheral blood. T cells were expanded from grafts used for
      transplantation, upon CD3/CD28 crosslinking and culture in interleukin-2.
      Phenotype and function of T cells were assessed by flow cytometry and mixed
      lymphocyte culture assays. T-cell receptor repertoire distribution was evaluated 
      with polymerase chain reaction-based spectratyping. We were able to amplify T
      cells to sufficient amounts for DLI in 13 out of 13 initiated expansions.
      Expanded T cells presented with an activated phenotype and could be induced to
      produce cytokines by a nonspecific stimulus. When exposed to allogeneic targets, 
      expanded CB T cells proliferated at comparable levels to their ex vivo and adult 
      blood counterparts. In summary, clinical expansion of CB T cells for DLI is
      feasible and may be a future modality for treatment of graft failure or relapse
      after SCT.
FAU - Okas, Mantas
AU  - Okas M
AD  - Centre for Allogeneic Stem Cell Transplantation and Division of Clinical
      Immunology, Karolinska University Hospital Huddinge, SE-141 86, Stockholm,
      Sweden. mantas.okas@ki.se
FAU - Gertow, Jens
AU  - Gertow J
FAU - Uzunel, Mehmet
AU  - Uzunel M
FAU - Karlsson, Helen
AU  - Karlsson H
FAU - Westgren, Magnus
AU  - Westgren M
FAU - Karre, Klas
AU  - Karre K
FAU - Ringden, Olle
AU  - Ringden O
FAU - Mattsson, Jonas
AU  - Mattsson J
FAU - Uhlin, Michael
AU  - Uhlin M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Immunother
JT  - Journal of immunotherapy (Hagerstown, Md. : 1997)
JID - 9706083
SB  - IM
MH  - Cell Culture Techniques/*methods
MH  - Cell Separation
MH  - *Cord Blood Stem Cell Transplantation
MH  - Fetal Blood
MH  - Flow Cytometry
MH  - Humans
MH  - Lymphocyte Culture Test, Mixed
MH  - T-Lymphocyte Subsets/cytology/*immunology
MH  - T-Lymphocytes/cytology/*immunology/*transplantation
EDAT- 2009/12/03 06:00
MHDA- 2010/03/03 06:00
CRDT- 2009/12/03 06:00
PHST- 2009/12/03 06:00 [entrez]
PHST- 2009/12/03 06:00 [pubmed]
PHST- 2010/03/03 06:00 [medline]
AID - 10.1097/CJI.0b013e3181b291a4 [doi]
PST - ppublish
SO  - J Immunother. 2010 Jan;33(1):96-105. doi: 10.1097/CJI.0b013e3181b291a4.


PMID- 19952734
OWN - NLM
STAT- MEDLINE
DCOM- 20100325
LR  - 20091229
IS  - 1531-7072 (Electronic)
IS  - 1070-5295 (Linking)
VI  - 16
IP  - 1
DP  - 2010 Feb
TI  - Extracorporeal support as a bridge to lung transplantation.
PG  - 69-73
LID - 10.1097/MCC.0b013e3283353ce0 [doi]
AB  - PURPOSE OF REVIEW: Allocation of grafts for lung transplantation has been
      directed in many countries to patients in life-threatening conditions. Advances
      in technology for extracorporeal devices led to new concepts and increased use
      for bridging to lung transplantation. Taking these two developments into account,
      it seems that bridging technologies are used more frequently around the world.
      RECENT FINDINGS: The durability of extracorporeal devices for some weeks was
      described in many institutional and case reports. The change in technology seems 
      to open a new era of possibilities. Use of this new technology not only in bridge
      to transplant but also as a bridge to recovery in acute respiratory distress
      syndrome patients was published most recently. Current and future use of
      extracorporeal gas exchange as an alternative to mechanical ventilation appears
      in the literature. Use of low resistance membranes in patients with pulmonary
      hypertension was described as a new therapeutical option. SUMMARY: Bridge to lung
      transplantation is of increasing importance with new allocation systems and the
      increasing demand. New extracorporeal technologies address this demand with
      reliable function for some weeks. But these developments also raise ethical
      questions of how to use these new tools wisely individually and also collectively
      for the field of lung transplantation.
FAU - Strueber, Martin
AU  - Strueber M
AD  - Department of Cardiothoracic, Transplant, and Vascular Surgery, Hannover Medical 
      School, Hannover, Germany. strueber.martin@mh-hannover.de
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Crit Care
JT  - Current opinion in critical care
JID - 9504454
SB  - IM
MH  - Extracorporeal Circulation/instrumentation/*methods
MH  - Humans
MH  - *Lung Transplantation
RF  - 32
EDAT- 2009/12/03 06:00
MHDA- 2010/03/26 06:00
CRDT- 2009/12/03 06:00
PHST- 2009/12/03 06:00 [entrez]
PHST- 2009/12/03 06:00 [pubmed]
PHST- 2010/03/26 06:00 [medline]
AID - 10.1097/MCC.0b013e3283353ce0 [doi]
PST - ppublish
SO  - Curr Opin Crit Care. 2010 Feb;16(1):69-73. doi: 10.1097/MCC.0b013e3283353ce0.


PMID- 19951811
OWN - NLM
STAT- MEDLINE
DCOM- 20100201
LR  - 20091202
IS  - 1558-0490 (Electronic)
IS  - 1056-4993 (Linking)
VI  - 19
IP  - 1
DP  - 2010 Jan
TI  - Ethics and risk management in administrative child and adolescent psychiatry.
PG  - 115-29; table of contents
LID - 10.1016/j.chc.2009.08.002 [doi]
AB  - This article examines ethics (the philosophic study of "doing the right thing")
      and risk management (the practice that seeks to manage the likelihood of "doing
      the wrong thing") and the relationship between them in the context of
      administrative child and adolescent psychiatry. Issues that affect child and
      adolescent psychiatrists who manage staff and business units and clinical
      practitioners who treat and manage individual patients are addressed.
      Malpractice, budgeting, credentialing, boundaries, assessment, documentation,
      treatment, research, dangerousness, and confidentiality are among the topics
      reviewed.
FAU - Sondheimer, Adrian
AU  - Sondheimer A
AD  - Division of Child and Adolescent Psychiatry, UMDNJ-New Jersey Medical School,
      Newark, NJ, USA. adriansondheimer@aol.com
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Child Adolesc Psychiatr Clin N Am
JT  - Child and adolescent psychiatric clinics of North America
JID - 9313451
SB  - IM
MH  - Adolescent
MH  - Adolescent Psychiatry/*ethics/legislation & jurisprudence/*organization &
      administration
MH  - Biomedical Research/ethics/legislation & jurisprudence/organization &
      administration
MH  - Child
MH  - Child Psychiatry/*ethics/legislation & jurisprudence/*organization &
      administration
MH  - Confidentiality/ethics/legislation & jurisprudence
MH  - Conflict of Interest/legislation & jurisprudence
MH  - Dangerous Behavior
MH  - Documentation/ethics/methods
MH  - *Ethics, Medical
MH  - Ethics, Research
MH  - Humans
MH  - Informed Consent/ethics/legislation & jurisprudence
MH  - Institutional Management Teams/ethics/legislation & jurisprudence/organization & 
      administration
MH  - Malpractice/legislation & jurisprudence
MH  - Practice Management, Medical/*ethics/legislation & jurisprudence/*organization & 
      administration
MH  - Risk Management/*ethics/legislation & jurisprudence/*organization &
      administration
MH  - United States
RF  - 45
EDAT- 2009/12/03 06:00
MHDA- 2010/02/02 06:00
CRDT- 2009/12/03 06:00
PHST- 2009/12/03 06:00 [entrez]
PHST- 2009/12/03 06:00 [pubmed]
PHST- 2010/02/02 06:00 [medline]
AID - S1056-4993(09)00084-4 [pii]
AID - 10.1016/j.chc.2009.08.002 [doi]
PST - ppublish
SO  - Child Adolesc Psychiatr Clin N Am. 2010 Jan;19(1):115-29; table of contents. doi:
      10.1016/j.chc.2009.08.002.


PMID- 19951807
OWN - NLM
STAT- MEDLINE
DCOM- 20100201
LR  - 20091202
IS  - 1558-0490 (Electronic)
IS  - 1056-4993 (Linking)
VI  - 19
IP  - 1
DP  - 2010 Jan
TI  - The history of managed care and the role of the child and adolescent
      psychiatrist.
PG  - 63-74; table of contents
LID - 10.1016/j.chc.2009.08.009 [doi]
AB  - The child and adolescent psychiatrist cannot practice in today's world without
      interacting with the world of insurance and managed care. This article reviews
      the history of the development of the managed care industry. It also examines the
      variety of roles clinicians play, whether as members of physician networks, as a 
      peer or utilization reviewers, or as medical directors. The skills required of
      the physician employee and the contractual and ethical concerns are discussed.
FAU - Glasser, Martin
AU  - Glasser M
AD  - Behavioral Health, Anthem Blue Cross National Accounts, Drive San Diego, CA
      921232658, USA. martin.glasser@wellpoint.com
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - Child Adolesc Psychiatr Clin N Am
JT  - Child and adolescent psychiatric clinics of North America
JID - 9313451
SB  - IM
MH  - Adolescent
MH  - Adolescent Psychiatry/*history
MH  - Child
MH  - Child Psychiatry/*history/organization & administration
MH  - Ethics, Medical/education/*history
MH  - History, 19th Century
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Managed Care Programs/*history/organization & administration
MH  - Physician's Role/*history
MH  - United States
EDAT- 2009/12/03 06:00
MHDA- 2010/02/02 06:00
CRDT- 2009/12/03 06:00
PHST- 2009/12/03 06:00 [entrez]
PHST- 2009/12/03 06:00 [pubmed]
PHST- 2010/02/02 06:00 [medline]
AID - S1056-4993(09)00089-3 [pii]
AID - 10.1016/j.chc.2009.08.009 [doi]
PST - ppublish
SO  - Child Adolesc Psychiatr Clin N Am. 2010 Jan;19(1):63-74; table of contents. doi: 
      10.1016/j.chc.2009.08.009.


PMID- 19949799
OWN - NLM
STAT- MEDLINE
DCOM- 20100804
LR  - 20211020
IS  - 1432-1084 (Electronic)
IS  - 0938-7994 (Linking)
VI  - 20
IP  - 6
DP  - 2010 Jun
TI  - Quantification of renal allograft perfusion using arterial spin labeling MRI:
      initial results.
PG  - 1485-91
LID - 10.1007/s00330-009-1675-0 [doi]
AB  - OBJECTIVE: To quantify renal allograft perfusion in recipients with stable
      allograft function and acute decrease in allograft function using nonenhanced
      flow-sensitive alternating inversion recovery (FAIR)-TrueFISP arterial spin
      labeling (ASL) MR imaging. METHODS: Following approval of the local ethics
      committee, 20 renal allograft recipients were included in this study. ASL
      perfusion measurement and an anatomical T2-weighted single-shot fast spin-echo
      (HASTE) sequence were performed on a 1.5-T scanner (Magnetom Avanto, Siemens,
      Erlangen, Germany). T2-weighted MR urography was performed in patients with
      suspected ureteral obstruction. Patients were assigned to three groups: group a, 
      6 patients with stable allograft function over the previous 4 months; group b, 7 
      patients with good allograft function who underwent transplantation during the
      previous 3 weeks; group c, 7 allograft recipients with an acute deterioration of 
      renal function. RESULTS: Mean cortical perfusion values were 304.8 +/- 34.4,
      296.5 +/- 44.1, and 181.9 +/- 53.4 mg/100 ml/min for groups a, b and c,
      respectively. Reduction in cortical perfusion in group c was statistically
      significant. CONCLUSION: Our results indicate that ASL is a promising technique
      for nonenhanced quantification of cortical perfusion of renal allografts. Further
      studies are required to determine the clinical value of ASL for monitoring renal 
      allograft recipients.
FAU - Lanzman, Rotem S
AU  - Lanzman RS
AD  - Department of Radiology, University Hospital Dusseldorf, Moorenstr 5, 40225
      Dusseldorf, Germany. rotemshlomo@yahoo.de
FAU - Wittsack, Hans-Jorg
AU  - Wittsack HJ
FAU - Martirosian, Petros
AU  - Martirosian P
FAU - Zgoura, Panagiota
AU  - Zgoura P
FAU - Bilk, Philip
AU  - Bilk P
FAU - Kropil, Patric
AU  - Kropil P
FAU - Schick, Fritz
AU  - Schick F
FAU - Voiculescu, Adina
AU  - Voiculescu A
FAU - Blondin, Dirk
AU  - Blondin D
LA  - eng
PT  - Journal Article
DEP - 20091201
PL  - Germany
TA  - Eur Radiol
JT  - European radiology
JID - 9114774
RN  - 0 (Spin Labels)
SB  - IM
MH  - *Algorithms
MH  - Female
MH  - Humans
MH  - Image Enhancement/methods
MH  - Image Interpretation, Computer-Assisted/*methods
MH  - Kidney Failure, Chronic/*pathology/*surgery
MH  - Kidney Transplantation/*pathology
MH  - Magnetic Resonance Angiography/*methods
MH  - Male
MH  - Middle Aged
MH  - Models, Biological
MH  - Models, Statistical
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Spin Labels
MH  - Treatment Outcome
EDAT- 2009/12/02 06:00
MHDA- 2010/08/05 06:00
CRDT- 2009/12/02 06:00
PHST- 2009/05/29 00:00 [received]
PHST- 2009/09/28 00:00 [accepted]
PHST- 2009/12/02 06:00 [entrez]
PHST- 2009/12/02 06:00 [pubmed]
PHST- 2010/08/05 06:00 [medline]
AID - 10.1007/s00330-009-1675-0 [doi]
PST - ppublish
SO  - Eur Radiol. 2010 Jun;20(6):1485-91. doi: 10.1007/s00330-009-1675-0. Epub 2009 Dec
      1.


PMID- 19949337
OWN - NLM
STAT- MEDLINE
DCOM- 20100325
LR  - 20100113
IS  - 1531-698X (Electronic)
IS  - 1040-8703 (Linking)
VI  - 22
IP  - 1
DP  - 2010 Feb
TI  - Preimplantation genetic diagnosis for haematologic conditions.
PG  - 28-34
LID - 10.1097/MOP.0b013e3283350d77 [doi]
AB  - PURPOSE OF REVIEW: This review will inform the clinician about the application,
      success rates and limitations of preimplantation genetic diagnosis (PGD) for
      haematologic disease to enable clinicians to offer couples with reproductive risk
      a realistic view of possible treatments. The molecular techniques used to
      diagnose disease mutations are described, including the newest technologies using
      whole genome amplification (WGA) and preimplantation genetic haplotyping (PGH) of
      embryos. The history and ethics involved in performing PGD together with human
      leukocyte antigen (HLA) testing (PGD-H) to create matched siblings suitable for
      haematopoietic stem cell transplant (HSCT) are discussed. RECENT FINDINGS: The
      greatest diagnostic hurdle in PGD is the paucity of molecular material in the
      single embryonic cell. WGA allows amplification of the entire genome, which
      greatly simplifies mutation analysis and increases the possibilities of multiple 
      simultaneous genetic diagnoses. PGH can be applied to the amplified material, and
      may enable the application of PGD to the less common haematological mutations,
      and the diagnosis of nonaffected male progeny in cases of X-linked haematologic
      diseases. SUMMARY: PGD to exclude embryos carrying serious haematologic disease
      is a viable alternative to prenatal diagnosis for couples who wish to avoid
      having affected children and for whom therapeutic termination of affected
      pregnancies is unacceptable. PGD is not available for all haematologic mutations,
      is expensive, time consuming and does not guarantee a pregnancy. PGD-H is more
      diagnostically and ethically challenging, especially when there is the time
      constraint of urgent provision of HLA-matched stem cells for a sick sibling. To
      date there is only a handful of reported cases of successful HSCT from siblings
      created by embryo selection. The evolving technology of PGH following WGA may
      increase the diagnostic scope and availability of PGD in the future, but certain 
      limitations will remain.
FAU - El-Toukhy, Tarek
AU  - El-Toukhy T
AD  - Centre for Preimplantation Genetic Diagnosis, Guy's and St. Thomas' Hospital NHS 
      Foundation Trust, London, UK. tarek.el-toukhy@gstt.nhs.uk
FAU - Bickerstaff, Helen
AU  - Bickerstaff H
FAU - Meller, Simon
AU  - Meller S
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Pediatr
JT  - Current opinion in pediatrics
JID - 9000850
SB  - IM
MH  - Female
MH  - Haplotypes
MH  - Hematologic Diseases/*diagnosis/*genetics
MH  - Hematopoietic Stem Cell Transplantation
MH  - Histocompatibility Testing
MH  - Humans
MH  - Pregnancy
MH  - *Preimplantation Diagnosis
RF  - 50
EDAT- 2009/12/02 06:00
MHDA- 2010/03/26 06:00
CRDT- 2009/12/02 06:00
PHST- 2009/12/02 06:00 [entrez]
PHST- 2009/12/02 06:00 [pubmed]
PHST- 2010/03/26 06:00 [medline]
AID - 10.1097/MOP.0b013e3283350d77 [doi]
PST - ppublish
SO  - Curr Opin Pediatr. 2010 Feb;22(1):28-34. doi: 10.1097/MOP.0b013e3283350d77.


PMID- 19948531
OWN - NLM
STAT- MEDLINE
DCOM- 20110415
LR  - 20100316
IS  - 1473-0480 (Electronic)
IS  - 0306-3674 (Linking)
VI  - 44
IP  - 3
DP  - 2010 Feb
TI  - 'I am in blood Stepp'd in so far...': ethical dilemmas and the sports team
      doctor.
PG  - 175-8
LID - 10.1136/bjsm.2009.068056 [doi]
AB  - There are many ethical dilemmas that are unique to sports medicine because of the
      unusual clinical environment of caring for players within the context of a team
      whose primary objective is to win. Many of these ethical issues arise because the
      traditional relationship between doctor and patient is distorted or absent. The
      emergence of a doctor-patient-team triad has created a scenario in which the
      team's priority can conflict with or even replace the doctor's primary obligation
      to player well-being. As a result, the customary ethical norms that provide
      guidelines for most forms of clinical practice, such as patient autonomy and
      confidentiality, are not easily translated in the field of sports medicine.
      Sports doctors are frequently under intense pressure, whether implicit or
      explicit, from management, coaches, trainers and agents, to improve performance
      of the athlete in the short term rather than considering the long-term sequelae
      of such decisions. A myriad of ethical dilemmas are encountered, and for many of 
      these dilemmas there are no right answers. In this article, a number of ethical
      principles and how they relate to sports medicine are discussed. To conclude, a
      list of guidelines has been drawn up to offer some support to doctors facing an
      ethical quandary, the most important of which is 'do not abdicate your
      responsibility to the individual player.''I am in blood Stepp'd in so far that,
      should I wade no more, Returning would be as tedious as to go o'er' -Macbeth: Act
      III, Scene IV, William Shakespeare.
FAU - Devitt, Brian Meldan
AU  - Devitt BM
AD  - Cappagh National Orthopaedic Hospital, Dublin, Ireland. bdevitt@hotmail.com
FAU - McCarthy, Conor
AU  - McCarthy C
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Review
DEP - 20091129
PL  - England
TA  - Br J Sports Med
JT  - British journal of sports medicine
JID - 0432520
SB  - IM
MH  - Ethics, Medical
MH  - History, 19th Century
MH  - History, Ancient
MH  - Humans
MH  - Practice Guidelines as Topic
MH  - Professional Autonomy
MH  - Professional Misconduct/ethics
MH  - Professional Practice/*ethics
MH  - Sports Medicine/*ethics/history
EDAT- 2009/12/02 06:00
MHDA- 2011/04/19 06:00
CRDT- 2009/12/02 06:00
PHST- 2009/12/02 06:00 [entrez]
PHST- 2009/12/02 06:00 [pubmed]
PHST- 2011/04/19 06:00 [medline]
AID - bjsm.2009.068056 [pii]
AID - 10.1136/bjsm.2009.068056 [doi]
PST - ppublish
SO  - Br J Sports Med. 2010 Feb;44(3):175-8. doi: 10.1136/bjsm.2009.068056. Epub 2009
      Nov 29.


PMID- 19948389
OWN - NLM
STAT- MEDLINE
DCOM- 20101101
LR  - 20100706
IS  - 1873-5134 (Electronic)
IS  - 0738-3991 (Linking)
VI  - 80
IP  - 2
DP  - 2010 Aug
TI  - 'Maybe it would be better if you spoke to my mother?' - genetic counseling and
      personal experience.
PG  - 260-1
LID - 10.1016/j.pec.2009.10.028 [doi]
AB  - This is the narratives of a family physician and a teacher of Medical Ethics, who
      herself suffers from Gaucher's disease. She was asked by a colleague to give an
      advice to a couple trying to decide whether to terminate a pregnancy of a fetus
      "like her". The ethical, emotional and communicational challenges of the
      conversation are described in this essay.
CI  - Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
FAU - Kannai, Ruth
AU  - Kannai R
AD  - Department of Family Medicine, Hadassah School of Medicine, Hebrew University, PO
      Box 12272, Jerusalem 91120, Israel. rkannai@gmail.com
LA  - eng
PT  - Journal Article
DEP - 20091130
PL  - Ireland
TA  - Patient Educ Couns
JT  - Patient education and counseling
JID - 8406280
MH  - Abortion, Induced/ethics/psychology
MH  - Communication
MH  - Decision Making/ethics
MH  - Female
MH  - Gaucher Disease/*diagnosis/genetics
MH  - *Genetic Counseling
MH  - Humans
MH  - Mothers
MH  - Physician-Patient Relations
MH  - Pregnancy
MH  - *Prenatal Diagnosis
EDAT- 2009/12/02 06:00
MHDA- 2010/11/03 06:00
CRDT- 2009/12/02 06:00
PHST- 2009/04/06 00:00 [received]
PHST- 2009/10/06 00:00 [revised]
PHST- 2009/10/24 00:00 [accepted]
PHST- 2009/12/02 06:00 [entrez]
PHST- 2009/12/02 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - S0738-3991(09)00518-7 [pii]
AID - 10.1016/j.pec.2009.10.028 [doi]
PST - ppublish
SO  - Patient Educ Couns. 2010 Aug;80(2):260-1. doi: 10.1016/j.pec.2009.10.028. Epub
      2009 Nov 30.


PMID- 19948388
OWN - NLM
STAT- MEDLINE
DCOM- 20110208
LR  - 20211203
IS  - 1873-5134 (Electronic)
IS  - 0738-3991 (Linking)
VI  - 80
IP  - 1
DP  - 2010 Jul
TI  - The physician's professional role in end-of-life decision-making: voices of
      racially and ethnically diverse physicians.
PG  - 3-9
LID - 10.1016/j.pec.2009.10.018 [doi]
AB  - OBJECTIVE: Previous studies have shown racial/ethnic differences in preferences
      for end-of-life (EOL) care. We aimed to describe values and beliefs guiding
      physicians' EOL decision-making and explore the relationship between physicians' 
      race/ethnicity and their decision-making. METHODS: Seven focus groups (3
      Caucasian, 2 African American, 2 Hispanic) with internists and subspecialists
      (n=26) were conducted. Investigators independently analyzed transcripts, assigned
      codes, compared findings, reconciled differences, and developed themes. RESULTS: 
      Four themes appeared to transcend physicians' race/ethnicity: (1) strong support 
      for the physician's role; (2) responding to "unreasonable" requests; (3)
      organizational factors; and (4) physician training and comfort with discussing
      EOL care. Five themes physicians seemed to manage differently based on
      race/ethnicity: (1) preventing and reducing the burden of surrogate
      decision-making; (2) responding to requests for "doing everything;" (3) influence
      of physician-patient racial/ethnic concordance/discordance; (4) cultural
      differences concerning truth-telling; and (5) spirituality and religious beliefs.
      CONCLUSIONS: Physicians in our multi-racial/ethnic sample emphasized their
      commitment to their professional role in EOL decision-making. Implicitly invoking
      the professional virtue of self-effacement, they were able to identify
      racially/ethnically common and diverse ethical challenges of EOL decision-making.
      PRACTICE IMPLICATIONS: Physicians should use professional virtues to tailor the
      EOL decision-making process in response to patients' race/ethnicity, based on
      patients' preferences.
CI  - Published by Elsevier Ireland Ltd.
FAU - Braun, Ursula K
AU  - Braun UK
AD  - Houston VA Health Services Research & Development Center of Excellence, The
      Houston Center for Quality of Care & Utilization Studies, Department of Veteran
      Affairs, Michael E. DeBakey VA Medical Center, Houston, TX, USA. ubraun@bcm.edu
FAU - Ford, Marvella E
AU  - Ford ME
FAU - Beyth, Rebecca J
AU  - Beyth RJ
FAU - McCullough, Laurence B
AU  - McCullough LB
LA  - eng
GR  - P30 AG028740/AG/NIA NIH HHS/United States
GR  - R03 AG022144/AG/NIA NIH HHS/United States
GR  - R03 AG022144-01/AG/NIA NIH HHS/United States
GR  - R03-AG022144-01/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20091130
PL  - Ireland
TA  - Patient Educ Couns
JT  - Patient education and counseling
JID - 8406280
MH  - Adult
MH  - *Advance Care Planning
MH  - African Americans/psychology
MH  - Attitude to Death/*ethnology
MH  - Cultural Diversity
MH  - Decision Making/*ethics
MH  - Ethnicity
MH  - Female
MH  - Focus Groups
MH  - Hispanic or Latino/psychology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Physician's Role/*psychology
MH  - Practice Patterns, Physicians'
MH  - Professional Role/*psychology
MH  - Qualitative Research
MH  - *Terminal Care
MH  - Whites/psychology
PMC - PMC2891864
MID - NIHMS158926
EDAT- 2009/12/02 06:00
MHDA- 2011/02/09 06:00
CRDT- 2009/12/02 06:00
PHST- 2009/04/21 00:00 [received]
PHST- 2009/10/21 00:00 [revised]
PHST- 2009/10/26 00:00 [accepted]
PHST- 2009/12/02 06:00 [entrez]
PHST- 2009/12/02 06:00 [pubmed]
PHST- 2011/02/09 06:00 [medline]
AID - S0738-3991(09)00508-4 [pii]
AID - 10.1016/j.pec.2009.10.018 [doi]
PST - ppublish
SO  - Patient Educ Couns. 2010 Jul;80(1):3-9. doi: 10.1016/j.pec.2009.10.018. Epub 2009
      Nov 30.


PMID- 19946812
OWN - NLM
STAT- MEDLINE
DCOM- 20110719
LR  - 20191210
IS  - 1745-7319 (Electronic)
IS  - 1745-7300 (Linking)
VI  - 17
IP  - 3
DP  - 2010 Sep
TI  - Structural validity and reliability of the integrated conflict and violence
      scale.
PG  - 141-4
LID - 10.1080/17457300903402176 [doi]
AB  - The study validated structure stability, reliability and sub-scale
      distinctiveness of integrated conflict and violence scale (ICVS) and was
      cross-sectional; war-affected grade 5 school children participated. ICV internal 
      factorial validity and reliability were evaluated; eigenvalue size and scree
      plots were used for factor selection. A variable retention factor load threshold 
      of >0.30 was used: Cronbach's alpha tests confirmed reliability increments.
      Pair-wise Pearson correlation tests evaluated sub-scale distinctiveness. Gulu
      University granted ethical clearance. A total of 280 grade 5 children from 50
      primary schools participated: 53% of them were males. Two factors accounted for
      100% of variability in attitudes; 18 variables were retained. Expelled variables 
      were: 'If I catch some one stealing my sugar cane I will fight' and 'a bully
      should be forgiven'. Sub-scale internal consistency reliability coefficients were
      0.73 and 0.65, respectively and distinctiveness correlation coefficient was
      -0.06. The ICVS was validated using standard criteria. Emerging two-factor scale 
      has acceptable psychometric properties especially factorial structure, internal
      consistency and sub-scale distinctiveness.
FAU - Mutto, Milton
AU  - Mutto M
AD  - Pincer Group Int, #72455, Kampala, 256 Uganda. milton.mutto@ki.se
FAU - Lawoko, Stephen
AU  - Lawoko S
FAU - Ovuga, Omilio
AU  - Ovuga O
FAU - Bangdiwala, Shrikant
AU  - Bangdiwala S
LA  - eng
PT  - Journal Article
PT  - Validation Study
PL  - England
TA  - Int J Inj Contr Saf Promot
JT  - International journal of injury control and safety promotion
JID - 101247254
SB  - IM
MH  - Adolescent
MH  - Child
MH  - *Conflict, Psychological
MH  - Female
MH  - Humans
MH  - Male
MH  - Schools
MH  - Surveys and Questionnaires/*standards
MH  - Uganda
MH  - Violence/*psychology
EDAT- 2009/12/01 06:00
MHDA- 2011/07/20 06:00
CRDT- 2009/12/01 06:00
PHST- 2009/12/01 06:00 [entrez]
PHST- 2009/12/01 06:00 [pubmed]
PHST- 2011/07/20 06:00 [medline]
AID - 917187526 [pii]
AID - 10.1080/17457300903402176 [doi]
PST - ppublish
SO  - Int J Inj Contr Saf Promot. 2010 Sep;17(3):141-4. doi: 10.1080/17457300903402176.


PMID- 19941447
OWN - NLM
STAT- MEDLINE
DCOM- 20101103
LR  - 20220317
IS  - 2212-3946 (Electronic)
IS  - 1574-888X (Linking)
VI  - 5
IP  - 2
DP  - 2010 Jun
TI  - Stem cells for hepatic regeneration: the role of adipose tissue derived
      mesenchymal stem cells.
PG  - 182-9
AB  - Severe hepatic dysfunctions including hepatic cirrhosis and hepatocarcinoma are
      life-threatening conditions for which effective medical treatments are needed.
      With the only effective treatment to date being orthotropic liver
      transplantation, alternative approaches are needed because of the limited number 
      of donors and the possibility of immune-rejection. One alternative is
      regenerative medicine, which holds promise for the development of a cell-based
      therapy enabling hepatic regeneration through transplantation of adipose
      tissue-derived mesenchymal stem cells (AT-MSCs) or hepatocyte-like cells
      generated from AT-MSCs. When compared with embryonic stem (ES) cells and induced 
      pluripotent stem (iPS) cells, the use of AT-MSCs as regenerative cells would be
      advantageous in regard to ethical and safety issues since AT-MSCs are somatic
      cells and have the potential to be used without in vitro culture. These
      autologous cells are immuno-compatible and exhibit controlled differentiation and
      multi-functional abilities and do not undergo post-transplantation rejection or
      unwanted differentiation such as formation of teratomas. AT-MSC-based therapies
      may provide a novel approach for hepatic regeneration and hepatocyte
      differentiation and thereby support hepatic function in diseased individuals.
FAU - Ishikawa, Tetsuya
AU  - Ishikawa T
AD  - Section for Studies on Metastasis, National Cancer Center Research Institute,
      1-1, Tsukiji 5-chome, Chuo-ku, Tokyo 104-0045, Japan.
FAU - Banas, Agnieszka
AU  - Banas A
FAU - Hagiwara, Keitaro
AU  - Hagiwara K
FAU - Iwaguro, Hideki
AU  - Iwaguro H
FAU - Ochiya, Takahiro
AU  - Ochiya T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Curr Stem Cell Res Ther
JT  - Current stem cell research & therapy
JID - 101272517
SB  - IM
MH  - Adipose Tissue/*pathology
MH  - Animals
MH  - Carcinoma, Hepatocellular/pathology/*therapy
MH  - Cell Differentiation
MH  - Hepatocytes/metabolism/pathology
MH  - Humans
MH  - Immune Tolerance
MH  - Induced Pluripotent Stem Cells/metabolism/pathology
MH  - Liver Cirrhosis/pathology/*therapy
MH  - Liver Neoplasms/pathology/*therapy
MH  - Liver Regeneration
MH  - Mesenchymal Stem Cells/immunology/*metabolism/pathology
MH  - Regenerative Medicine
MH  - Stem Cell Niche/*pathology
MH  - *Stem Cell Transplantation
RF  - 76
EDAT- 2009/11/28 06:00
MHDA- 2010/11/04 06:00
CRDT- 2009/11/28 06:00
PHST- 2009/05/01 00:00 [received]
PHST- 2009/07/28 00:00 [accepted]
PHST- 2009/11/28 06:00 [entrez]
PHST- 2009/11/28 06:00 [pubmed]
PHST- 2010/11/04 06:00 [medline]
AID - ABSTRACT # 34 [pii]
AID - 10.2174/157488810791268636 [doi]
PST - ppublish
SO  - Curr Stem Cell Res Ther. 2010 Jun;5(2):182-9. doi: 10.2174/157488810791268636.


PMID- 19940458
OWN - NLM
STAT- MEDLINE
DCOM- 20101223
LR  - 20100831
IS  - 1662-8063 (Electronic)
IS  - 1662-4246 (Linking)
VI  - 13
IP  - 6
DP  - 2010
TI  - Donors perceptions of consent to and feedback from biobank research: time to
      acknowledge diversity?
PG  - 345-52
LID - 10.1159/000262329 [doi]
AB  - BACKGROUND: Many studies have explored public perspectives on when and how to
      provide informed consent to biobank research and when to get feedback on research
      results. Little has been done to explore overarching trends in these studies.
      METHODS: The article is based on a critical reading of the literature found
      through Medline searches and the PRIVILEGED project compilation of empirical
      studies. RESULTS: I suggest that tissue type, procurement situation including who
      is asked to provide consent, and the biobank's geographical, social and
      historical context influence how various potential donors view the issues of
      consent, re-consent, and feedback of research results. In light of this,
      universal ethical standards for informed consent to and feedback of research
      results from biobank research seem to run contrary to the diversity of
      perceptions and expectations among different donors. CONCLUSION: To respect donor
      interests, it is necessary to pay more attention to diversity with regard to
      biobank types and different contexts for donation. We should avoid assuming that 
      words like 'biobank' and 'donor' can be used in a generic sense - always
      referring to the same - if we wish to respect and care for the diverse group of
      individuals who comprise the donating public.
FAU - Hoeyer, K
AU  - Hoeyer K
AD  - University of Copenhagen, Department of Public Health, Copenhagen, Denmark.
      k.hoeyer@pubhealth.ku.dk
LA  - eng
PT  - Journal Article
DEP - 20091126
PL  - Switzerland
TA  - Public Health Genomics
JT  - Public health genomics
JID - 101474167
SB  - IM
MH  - *Feedback
MH  - Humans
MH  - *Tissue Banks
MH  - *Tissue Donors
EDAT- 2009/11/27 06:00
MHDA- 2010/12/25 06:00
CRDT- 2009/11/27 06:00
PHST- 2009/05/25 00:00 [received]
PHST- 2009/07/30 00:00 [accepted]
PHST- 2009/11/27 06:00 [entrez]
PHST- 2009/11/27 06:00 [pubmed]
PHST- 2010/12/25 06:00 [medline]
AID - 000262329 [pii]
AID - 10.1159/000262329 [doi]
PST - ppublish
SO  - Public Health Genomics. 2010;13(6):345-52. doi: 10.1159/000262329. Epub 2009 Nov 
      26.


PMID- 19940207
OWN - NLM
STAT- MEDLINE
DCOM- 20100305
LR  - 20211203
IS  - 1758-1001 (Electronic)
IS  - 0004-5632 (Linking)
VI  - 47
IP  - Pt 1
DP  - 2010 Jan
TI  - Comparison between transcutaneous bilirubinometry and total serum bilirubin
      measurements in preterm infants <35 weeks gestation.
PG  - 72-7
LID - 10.1258/acb.2009.009072 [doi]
AB  - BACKGROUND: Neonatal hyperbilirubinaemia is a common treatable cause of brain
      injury. The treatment for this condition is phototherapy. The decision whether to
      use phototherapy is currently dependent upon serum bilirubin assay results.
      However, repeated blood sampling is not only traumatic but may also be a cause of
      anaemia in neonates. We evaluated a transcutaneous bilirubin assay method to
      determine whether it was suitable for routine use in preterm infants. METHODS:
      One hundred and eighty-three transcutaneous bilirubin measurements were taken
      contemporaneously with blood samples for laboratory measurement of serum
      bilirubin. The study was carried out with informed parental consent and approval 
      by the local research ethics committee. RESULTS: The transcutaneous bilirubin
      method (BiliChek) exhibited a consistent positive bias compared with the
      laboratory bilirubin assay. Consequently, for a given detection rate, the
      transcutaneous method had a higher screen positive rate, i.e. more neonates would
      be given phototherapy if transcutaneous bilirubin results were used to decide.
      There was a margin of safety in the transcutaneous bilirubin assay calibration.
      CONCLUSION: The BiliChek transcutaneous bilirubin assay is a safe alternative to 
      laboratory bilirubin assay in deciding whether to give preterm neonates
      phototherapy.
FAU - Ahmed, M
AU  - Ahmed M
AD  - Department of Paediatrics, Queen's Hospital, Burton Upon Trent, UK.
      mansoor.ahmed@burtonh-tr.wmids.nhs.uk
FAU - Mostafa, S
AU  - Mostafa S
FAU - Fisher, G
AU  - Fisher G
FAU - Reynolds, T M
AU  - Reynolds TM
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
DEP - 20091125
PL  - England
TA  - Ann Clin Biochem
JT  - Annals of clinical biochemistry
JID - 0324055
RN  - RFM9X3LJ49 (Bilirubin)
SB  - IM
MH  - Bilirubin/*analysis/blood/metabolism
MH  - Blood Chemical Analysis/*methods
MH  - Clinical Laboratory Techniques/instrumentation/*methods
MH  - Ethnicity
MH  - Gestational Age
MH  - Humans
MH  - Hyperbilirubinemia, Neonatal/blood/*diagnosis/metabolism
MH  - Infant, Newborn
MH  - *Infant, Premature/blood/metabolism
MH  - Neonatal Screening/methods
MH  - Skin/metabolism
MH  - Skin Pigmentation/physiology
MH  - Specimen Handling/methods
EDAT- 2009/11/27 06:00
MHDA- 2010/03/06 06:00
CRDT- 2009/11/27 06:00
PHST- 2009/11/27 06:00 [entrez]
PHST- 2009/11/27 06:00 [pubmed]
PHST- 2010/03/06 06:00 [medline]
AID - acb.2009.009072 [pii]
AID - 10.1258/acb.2009.009072 [doi]
PST - ppublish
SO  - Ann Clin Biochem. 2010 Jan;47(Pt 1):72-7. doi: 10.1258/acb.2009.009072. Epub 2009
      Nov 25.


PMID- 19937733
OWN - NLM
STAT- MEDLINE
DCOM- 20100302
LR  - 20091228
IS  - 1097-4644 (Electronic)
IS  - 0730-2312 (Linking)
VI  - 109
IP  - 1
DP  - 2010 Jan 1
TI  - Determinants of pluripotency: from avian, rodents, to primates.
PG  - 16-25
LID - 10.1002/jcb.22402 [doi]
AB  - Since mouse embryonic stem (ES) cells was first derived in 1981, the ability of
      this unprecedented cell type to self-renew and differentiate without limit has
      revolutionized the discovery tools that are used to study gene functions and
      development. Furthermore, they have inspired others to hunt for similar cells
      from other species. The derivation of human ES cells in 1998 has accelerated
      these discoveries and has also widely provoked public interest, due to both the
      scientific significance of these cells for human tissue regeneration and the
      ethical disputes over the use of donated early human embryos. However, this is no
      longer a barrier, with the recent discovery of methods that can convert
      differentiated somatic cells into ES-like cells or induced pluripotent stem (iPS)
      cells, by using defined reprogramming factors. This review attempts to summarize 
      the progresses in the derivation of ES cells (as well as other embryo-derived
      pluripotent cells) and iPS cells from various species. We will focus on the
      molecular and biological features of the cells, as well as the different
      determinants identified thus far to sustain their pluripotency.
FAU - Martins-Taylor, Kristen
AU  - Martins-Taylor K
AD  - Department of Genetics and Developmental Biology, University of Connecticut Stem 
      Cell Institute, University of Connecticut Health Center, Farmington, Connecticut 
      06030, USA.
FAU - Xu, Ren-He
AU  - Xu RH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - J Cell Biochem
JT  - Journal of cellular biochemistry
JID - 8205768
SB  - IM
MH  - Animals
MH  - Cell Differentiation/*physiology
MH  - Embryonic Stem Cells/*cytology/physiology
MH  - Humans
MH  - Pluripotent Stem Cells/*cytology/physiology
RF  - 87
EDAT- 2009/11/26 06:00
MHDA- 2010/03/03 06:00
CRDT- 2009/11/26 06:00
PHST- 2009/11/26 06:00 [entrez]
PHST- 2009/11/26 06:00 [pubmed]
PHST- 2010/03/03 06:00 [medline]
AID - 10.1002/jcb.22402 [doi]
PST - ppublish
SO  - J Cell Biochem. 2010 Jan 1;109(1):16-25. doi: 10.1002/jcb.22402.


PMID- 19937716
OWN - NLM
STAT- MEDLINE
DCOM- 20110131
LR  - 20161125
IS  - 1099-0879 (Electronic)
IS  - 1063-3995 (Linking)
VI  - 17
IP  - 5
DP  - 2010 Sep-Oct
TI  - Exploring the personal and professional impact of reflective practice groups: a
      survey of 18 cohorts from a UK clinical psychology training course.
PG  - 427-37
LID - 10.1002/cpp.660 [doi]
AB  - OBJECTIVES: Given the importance of reflective practice within clinical
      psychology and a lack of empirical research, this study aimed to investigate the 
      personal and professional impact of reflective practice groups (RPGs) for former 
      trainees. DESIGN: This study followed an analytic survey design utilizing a
      convenience sample of qualified clinical psychologists from a UK training
      programme. METHODS: A RPG questionnaire (RPGQ) was developed for the purposes of 
      the study. Following initial pilot work, 297 qualified psychologists were invited
      to complete the RPGQ. RESULTS: One hundred and twenty-four psychologists (42%)
      completed the RPGQ. Factor analysis yielded two underlying constructs labelled
      'value' and 'distress'. The RPGQ demonstrated significant internal and
      test-retest reliability. The majority rated the RPGs as valuable for personal and
      professional development and learning about group processes. Just under half
      however reported distress as a result of the groups. Whilst some trainees, who
      reported distress, were able to view the challenges positively, one-sixth were
      not. Potency of facilitation and group size significantly predicted levels of
      perceived value and distress. CONCLUSIONS: In view of the ethical issues raised
      by compulsory RPGs, recommendations were made to keep group sizes within an
      average of 10-13, utilize facilitators with sufficient training in group
      processes and ensure additional methods of reflective practice development are
      available. Further suggestions and recommendations for future research in
      relation to coping and personal learning style were also made.
CI  - (c) 2009 John Wiley & Sons, Ltd.
FAU - Knight, Katherine
AU  - Knight K
AD  - Department of Applied Social & Psychological Development, Canterbury Christ
      Church University, Kent, UK. Katherine.knight@oxleas.nhs.uk
FAU - Sperlinger, David
AU  - Sperlinger D
FAU - Maltby, Michael
AU  - Maltby M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Clin Psychol Psychother
JT  - Clinical psychology & psychotherapy
JID - 9416196
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Awareness
MH  - Clinical Competence/*standards
MH  - Cohort Studies
MH  - Curriculum/statistics & numerical data
MH  - Education, Graduate/statistics & numerical data
MH  - Factor Analysis, Statistical
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Professional Practice/*standards
MH  - Psychology, Clinical/*education/standards
MH  - Self Efficacy
MH  - *Self-Assessment
MH  - *Surveys and Questionnaires
MH  - Teaching
MH  - United Kingdom
EDAT- 2009/11/26 06:00
MHDA- 2011/02/01 06:00
CRDT- 2009/11/26 06:00
PHST- 2009/11/26 06:00 [entrez]
PHST- 2009/11/26 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
AID - 10.1002/cpp.660 [doi]
PST - ppublish
SO  - Clin Psychol Psychother. 2010 Sep-Oct;17(5):427-37. doi: 10.1002/cpp.660.


PMID- 19936964
OWN - NLM
STAT- MEDLINE
DCOM- 20100621
LR  - 20211020
IS  - 1572-8633 (Electronic)
IS  - 1386-7423 (Linking)
VI  - 13
IP  - 2
DP  - 2010 May
TI  - The use of human tissue in epidemiological research; ethical and legal
      considerations in two biobanks in Belgium.
PG  - 169-75
LID - 10.1007/s11019-009-9230-y [doi]
AB  - This paper discusses the legal implications of setting up two new biobanks in
      Belgium. The first is hospital-based and will archive tissue from patients with
      haematologic cancer, whereas the second is linked to a general practice based
      morbidity registry and will involve storage of blood samples. To date, Belgium
      has no specific legislation that regulates storage of human tissue and related
      databases. Several issues concerning the protection of individuals with regard to
      the processing of personal medical data are discussed from the existing privacy
      legislation. We will address the principle of consent (broad versus specific) and
      the type of data recorded (anonymous, encoded and identifiable) for both
      biobanks.
FAU - Truyers, Carla
AU  - Truyers C
AD  - Department of General Practice, Katholieke Universiteit Leuven, Kapucijnenvoer
      33, Blok j, bus 7001, 3000, Leuven, Belgium. carla.truyers@med.kuleuven.be
FAU - Kellen, Eliane
AU  - Kellen E
FAU - Arbyn, Marc
AU  - Arbyn M
FAU - Trommelmans, Leen
AU  - Trommelmans L
FAU - Nys, Herman
AU  - Nys H
FAU - Hensen, Karen
AU  - Hensen K
FAU - Aertgeerts, Bert
AU  - Aertgeerts B
FAU - Bartholomeeusen, Stefaan
AU  - Bartholomeeusen S
FAU - Hansson, Mats
AU  - Hansson M
FAU - Buntinx, Frank
AU  - Buntinx F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Med Health Care Philos
JT  - Medicine, health care, and philosophy
JID - 9815900
SB  - IM
MH  - Belgium
MH  - Blood Banks/*ethics
MH  - Confidentiality
MH  - *Epidemiologic Studies
MH  - Hematologic Neoplasms
MH  - Humans
MH  - Informed Consent
MH  - Tissue Banks/*ethics
EDAT- 2009/11/26 06:00
MHDA- 2010/06/22 06:00
CRDT- 2009/11/26 06:00
PHST- 2009/11/26 06:00 [entrez]
PHST- 2009/11/26 06:00 [pubmed]
PHST- 2010/06/22 06:00 [medline]
AID - 10.1007/s11019-009-9230-y [doi]
PST - ppublish
SO  - Med Health Care Philos. 2010 May;13(2):169-75. doi: 10.1007/s11019-009-9230-y.


PMID- 19935716
OWN - NLM
STAT- MEDLINE
DCOM- 20100312
LR  - 20211203
IS  - 1476-5594 (Electronic)
IS  - 0950-9232 (Linking)
VI  - 29
IP  - 7
DP  - 2010 Feb 18
TI  - Embryoid body formation of human amniotic fluid stem cells depends on mTOR.
PG  - 966-77
LID - 10.1038/onc.2009.405 [doi]
AB  - Human amniotic fluid stem cells (hAFSCs) harbor high proliferative capacity and
      high differentiation potential and do not raise the ethical concerns associated
      with human embryonic stem cells. The formation of three-dimensional aggregates
      known as embryoid bodies (EBs) is the principal step in the differentiation of
      pluripotent embryonic stem cells. Using c-Kit-positive hAFSC lines, we show here 
      that these stem cells harbor the potential to form EBs. As part of the two kinase
      complexes, mTORC1 and mTORC2, mammalian target of rapamycin (mTOR) is the key
      component of an important signaling pathway, which is involved in the regulation 
      of cell proliferation, growth, tumor development and differentiation. Blocking
      intracellular mTOR activity through the inhibitor rapamycin or through specific
      small interfering RNA approaches revealed hAFSC EB formation to depend on mTORC1 
      and mTORC2. These findings demonstrate hAFSCs to be a new and powerful biological
      system to recapitulate the three-dimensional and tissue level contexts of in vivo
      development and identify the mTOR pathway to be essential for this process.
FAU - Valli, A
AU  - Valli A
AD  - Department of Medical Genetics, Medical University of Vienna, Vienna, Austria.
FAU - Rosner, M
AU  - Rosner M
FAU - Fuchs, C
AU  - Fuchs C
FAU - Siegel, N
AU  - Siegel N
FAU - Bishop, C E
AU  - Bishop CE
FAU - Dolznig, H
AU  - Dolznig H
FAU - Madel, U
AU  - Madel U
FAU - Feichtinger, W
AU  - Feichtinger W
FAU - Atala, A
AU  - Atala A
FAU - Hengstschlager, M
AU  - Hengstschlager M
LA  - eng
GR  - R01 HD060097/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091123
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - 0 (CRTC2 protein, human)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Multiprotein Complexes)
RN  - 0 (Proteins)
RN  - 0 (Transcription Factors)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 1)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Amniotic Fluid/*cytology
MH  - Animals
MH  - Cell Aggregation
MH  - Cell Line
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins/*metabolism
MH  - Mechanistic Target of Rapamycin Complex 1
MH  - Multiprotein Complexes
MH  - Protein Serine-Threonine Kinases/*metabolism
MH  - Proteins
MH  - Stem Cells/*cytology/*metabolism
MH  - TOR Serine-Threonine Kinases
MH  - Transcription Factors/metabolism
PMC - PMC8330845
MID - NIHMS511193
EDAT- 2009/11/26 06:00
MHDA- 2010/03/13 06:00
CRDT- 2009/11/26 06:00
PHST- 2009/11/26 06:00 [entrez]
PHST- 2009/11/26 06:00 [pubmed]
PHST- 2010/03/13 06:00 [medline]
AID - onc2009405 [pii]
AID - 10.1038/onc.2009.405 [doi]
PST - ppublish
SO  - Oncogene. 2010 Feb 18;29(7):966-77. doi: 10.1038/onc.2009.405. Epub 2009 Nov 23.


PMID- 19935673
OWN - NLM
STAT- MEDLINE
DCOM- 20100603
LR  - 20211020
IS  - 1745-7262 (Electronic)
IS  - 1008-682X (Linking)
VI  - 12
IP  - 2
DP  - 2010 Mar
TI  - Quantified gene expression levels for phase I/II metabolizing enzyme and estrogen
      receptor levels in benign prostate from cohorts designated as high-risk (UK)
      versus low-risk (India) for adenocarcinoma at this organ site: a preliminary
      study.
PG  - 203-14
LID - 10.1038/aja.2009.71 [doi]
AB  - Risk of clinically significant prostate adenocarcinoma (CaP) varies worldwide,
      although there is a uniform prevalence of latent disease. A hormone-responsive
      tissue, the prostate possesses the metabolizing capacity to biotransform a
      variety of environmental procarcinogens or endogenous hormones. Whether such
      metabolizing capacity or estrogen receptor (ER) status underlies these
      demographic differences in susceptibility to CaP remains unclear. With
      appropriate ethical permission, verified-benign tissues were obtained following
      transurethral resection of the prostate from a high-risk region (n = 12
      UK-resident Caucasians) and a typically low-risk region (n = 14 India-resident
      Asians). Quantitative gene expression analysis was employed for cytochrome P450
      (CYP)1B1, N-acetyltransferase (NAT)1, NAT2, catechol-O-methyl transferase (COMT),
      sulfotransferase (SULT)1A1, ERalpha, ERbeta and aromatase (CYP19A1). To quantify 
      the presence or absence of CYP1B1, ERalpha or ERbeta, and to identify their in
      situ localization, immunohistochemistry was carried out. The two cohorts had
      reasonably well-matched serum levels of prostate-specific antigen or hormones.
      Expression levels for the candidate genes investigated were similar. However,
      clear differences in protein levels for CYP1B1 and ERbeta were noted. Staining
      for CYP1B1 tended to be nuclear-associated in the basal glandular epithelial
      cells, and in UK-resident Caucasian tissues was present at a higher (P = 0.006)
      level compared with that from India-resident Asians. In contrast, a higher level 
      of positive ERbeta staining was noted in prostates from India-resident Asians.
      These study findings point to differences in metabolizing capacity and ER status 
      in benign prostate tissues that might modulate susceptibility to the emergence of
      clinically significant CaP in demographically distinct populations.
FAU - Singh, Paras B
AU  - Singh PB
AD  - Centre for Biophotonics, Lancaster Environment Centre, Lancaster University,
      Bailrigg, UK.
FAU - Ragavan, Narasimhan
AU  - Ragavan N
FAU - Ashton, Katherine M
AU  - Ashton KM
FAU - Basu, Prabir
AU  - Basu P
FAU - Nadeem, Sayeed M
AU  - Nadeem SM
FAU - Nicholson, Caroline M
AU  - Nicholson CM
FAU - Krishna, R K Gopala
AU  - Krishna RK
FAU - Matanhelia, Shyam S
AU  - Matanhelia SS
FAU - Martin, Francis L
AU  - Martin FL
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20091123
PL  - China
TA  - Asian J Androl
JT  - Asian journal of andrology
JID - 100942132
RN  - 0 (DNA Primers)
RN  - 0 (Enzymes)
RN  - 0 (Receptors, Estrogen)
SB  - IM
MH  - Adenocarcinoma/enzymology/*metabolism/pathology
MH  - Base Sequence
MH  - Cohort Studies
MH  - DNA Primers
MH  - Enzymes/*metabolism
MH  - Humans
MH  - India
MH  - Male
MH  - Prostate/enzymology/*metabolism
MH  - Prostatic Neoplasms/enzymology/*metabolism/pathology
MH  - Receptors, Estrogen/*metabolism
MH  - United Kingdom
PMC - PMC3739086
EDAT- 2009/11/26 06:00
MHDA- 2010/06/04 06:00
CRDT- 2009/11/26 06:00
PHST- 2009/11/26 06:00 [entrez]
PHST- 2009/11/26 06:00 [pubmed]
PHST- 2010/06/04 06:00 [medline]
AID - aja200971 [pii]
AID - 10.1038/aja.2009.71 [doi]
PST - ppublish
SO  - Asian J Androl. 2010 Mar;12(2):203-14. doi: 10.1038/aja.2009.71. Epub 2009 Nov
      23.


PMID- 19935101
OWN - NLM
STAT- MEDLINE
DCOM- 20100315
LR  - 20161018
IS  - 1533-4287 (Electronic)
IS  - 1064-8011 (Linking)
VI  - 24
IP  - 1
DP  - 2010 Jan
TI  - Optimal loading for the development of peak power output in professional rugby
      players.
PG  - 43-7
LID - 10.1519/JSC.0b013e3181c63c64 [doi]
AB  - The ability to develop high levels of muscular power is considered an essential
      component of success in many sporting activities; however, the optimal load for
      the development of peak power during training remains controversial. Our aim in
      the present study was to determine the optimal load required to observe peak
      power output during the ballistic bench throw (BBT) and squat jump (SJ) in
      professional rugby players. Forty-seven, professional, male, rugby players of
      (mean +/- SD) mass 101.3 +/- 12.8 kg and height 1.82 +/- 0.08 m volunteered and
      gave informed consent for this study, which was approved by a university ethics
      committee. Players performed BBT at loads of 20, 30, 40, 50, and 60% of their
      predetermined 1 repetition maximum (1RM) and SJ at loads of 0, (body mass only), 
      20, 30, 40, 50, and 60% of their predetermined 1RM in a randomized and balanced
      order. Power output (PO) was determined by measurement of barbell displacement
      with subsequent calculation of velocity, force, and power. Relative load had a
      significant effect on PO for both the BBT (effect size eta(2): 0.297, p < 0.001) 
      and SJ (Effect Size eta(2): 0.709, p < 0.001). Peak power output was produced
      when the athletes worked against an external load equal to 30% 1RM for the upper 
      body and 0% 1RM for the lower body.
FAU - Bevan, Huw R
AU  - Bevan HR
AD  - Sports and Exercise Science Research Group, Swansea University, Swansea, UK.
FAU - Bunce, Paul J
AU  - Bunce PJ
FAU - Owen, Nick J
AU  - Owen NJ
FAU - Bennett, Mark A
AU  - Bennett MA
FAU - Cook, Christian J
AU  - Cook CJ
FAU - Cunningham, Dan J
AU  - Cunningham DJ
FAU - Newton, Robert U
AU  - Newton RU
FAU - Kilduff, Liam P
AU  - Kilduff LP
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Strength Cond Res
JT  - Journal of strength and conditioning research
JID - 9415084
SB  - IM
MH  - Adult
MH  - Exercise/physiology
MH  - Football/*physiology
MH  - Humans
MH  - Male
MH  - Muscle Strength/*physiology
MH  - Physical Endurance/*physiology
MH  - Physical Fitness/physiology
MH  - Resistance Training
EDAT- 2009/11/26 06:00
MHDA- 2010/03/17 06:00
CRDT- 2009/11/26 06:00
PHST- 2009/11/26 06:00 [entrez]
PHST- 2009/11/26 06:00 [pubmed]
PHST- 2010/03/17 06:00 [medline]
AID - 10.1519/JSC.0b013e3181c63c64 [doi]
PST - ppublish
SO  - J Strength Cond Res. 2010 Jan;24(1):43-7. doi: 10.1519/JSC.0b013e3181c63c64.


PMID- 19935072
OWN - NLM
STAT- MEDLINE
DCOM- 20100908
LR  - 20220311
IS  - 1365-2346 (Electronic)
IS  - 0265-0215 (Linking)
VI  - 27
IP  - 3
DP  - 2010 Mar
TI  - Ultrasound-guided external jugular vein cannulation for central venous access by 
      inexperienced trainees.
PG  - 300-3
LID - 10.1097/EJA.0b013e328333c2d6 [doi]
AB  - BACKGROUND AND OBJECTIVE: The insertion of central venous catheters via the
      external jugular vein (EJV) is not always practical because of the relatively
      frequent failure rate; thus, the internal jugular approach is generally used.
      Data from the literature suggest that ultrasound-guided catheterization of the
      internal jugular vein is superior to the surface anatomy landmark technique and, 
      therefore, should be the method of choice. We evaluated the value of ultrasound
      guidance in the learning process of central venous cannulation via EJV by
      similarly inexperienced trainees. METHODS: In this prospective randomized study, 
      60 patients were assigned to two groups: group SA (surface anatomy; n = 30)
      underwent insertion of the central venous catheter using landmark guidance and
      group US (ultrasound; n = 30) underwent insertion using ultrasound guidance. In
      all patients, catheter insertion through the right EJV was performed by trainees 
      in their second year of training. Ultrasound guidance was carried out by the same
      ultrasound specialist. The following parameters were evaluated in all patients:
      the number of successful punctures of the right EJV, the total number of attempts
      and the time to vein puncture; the number of successful insertions of the central
      venous catheter, the number of attempts and the duration of catheterization (from
      puncture of EJV to external fixation of the catheter); and the incidence of
      complications. The study was approved by the institutional ethics committee, and 
      all patients gave written informed consent. Data were expressed as mean +/- SD.
      Student's t-test, Mann-Whitney test and chi2-test were used for analysis and P < 
      0.05 was considered statistically significant. The power of the study was 85%.
      RESULTS: The EJV puncture was successful in 24 out of 30 (80%) patients from
      group SA and in 22 out of 30 (73%) patients from group US (P = NS). There were no
      statistically significant differences between the groups regarding the mean time 
      to perform the vein puncture and the number of attempts. The insertion of the
      central venous catheter was performed successfully in 10 (33%) patients from
      group SA and six (20%) patients from group US. The success rate of central
      cannulation via the EJV approach was 10 out of 24 (42%) in group SA and six out
      of 22 (27%) in group US (P = NS). The total time for insertion and the number of 
      attempts were similar in both groups (P = NS). Local haematoma occurred in 11
      patients in group SA and in three patients in group US (P = NS). CONCLUSION: Our 
      results demonstrate no significant differences between the conventional surface
      anatomy landmark technique and the ultrasound-guided technique for the insertion 
      of a central venous catheter via EJV by inexperienced trainees.
FAU - Mitre, Calin I
AU  - Mitre CI
AD  - Department of Anaesthesia and Intensive Care, University of Medicine and Pharmacy
      Iuliu Hatieganu, Emergency Hospital Octavian Fodor, Cluj-Napoca, Romania.
      cmitre2001@yahoo.com
FAU - Golea, Adela
AU  - Golea A
FAU - Acalovschi, Iurie
AU  - Acalovschi I
FAU - Mocan, Teodora
AU  - Mocan T
FAU - Caea, Ana-Maria
AU  - Caea AM
FAU - Ruta, Claudia
AU  - Ruta C
FAU - Mariana, Muresan
AU  - Mariana M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - Eur J Anaesthesiol
JT  - European journal of anaesthesiology
JID - 8411711
SB  - IM
MH  - Aged
MH  - Catheterization/adverse effects/methods
MH  - Catheterization, Central Venous/adverse effects/*methods
MH  - Female
MH  - Humans
MH  - Internship and Residency/*methods
MH  - Jugular Veins/*diagnostic imaging
MH  - Male
MH  - Middle Aged
MH  - Monitoring, Intraoperative/adverse effects/methods
MH  - Prospective Studies
MH  - Punctures/adverse effects/methods
MH  - Ultrasonography, Interventional/adverse effects/*methods
EDAT- 2009/11/26 06:00
MHDA- 2010/09/09 06:00
CRDT- 2009/11/26 06:00
PHST- 2009/11/26 06:00 [entrez]
PHST- 2009/11/26 06:00 [pubmed]
PHST- 2010/09/09 06:00 [medline]
AID - 10.1097/EJA.0b013e328333c2d6 [doi]
PST - ppublish
SO  - Eur J Anaesthesiol. 2010 Mar;27(3):300-3. doi: 10.1097/EJA.0b013e328333c2d6.


PMID- 19933427
OWN - NLM
STAT- MEDLINE
DCOM- 20100517
LR  - 20100226
IS  - 1525-3163 (Electronic)
IS  - 0021-8812 (Linking)
VI  - 88
IP  - 3
DP  - 2010 Mar
TI  - Effect of polymorphisms in candidate genes on reproduction traits in Finnish pig 
      populations.
PG  - 821-7
LID - 10.2527/jas.2009-2426 [doi]
AB  - Reproduction traits play an important role in economically viable piglet
      production and are closely related to the quality and length of the productive
      life of the sow. A increased removal rate of young sows is undesirable not only
      because of the associated financial penalties incurred, but also because of
      ethical concerns. Candidate genes and gene pathways have been identified for
      fertility in model species, and recent studies have provided evidence that
      polymorphisms within these genes are associated with reproduction traits in
      American Yorkshire/Large White and Landrace populations. In this study we
      evaluated the impact of single polymorphisms (n = 7) in 7 candidate genes on
      reproductive efficiency in Finnish Yorkshire (n = 280) and Landrace (n = 271)
      populations: IGFBP1, IGFBP2, IGFBP3, IGFBP5, CPTIA (carnitine
      O-palmitoyltransferase I), COX2 (PG-endoperoxide synthase 2, also known as
      cyclooxygenase-2), and SLC22A5 [organic cation/carnitine transporter 2 (solute
      carrier family member I), OCTN2]. In the Finnish Yorkshire population, only 4 of 
      the analyzed markers were polymorphic. Significant effects on farrowing time were
      detected from the Yorkshire data, with polymorphisms within the genes CPT1A [a
      (allele substitution effect of allele A) = 2.97 d for age at first farrowing)],
      IGFBP3 (a = 0.54 d for farrowing interval of parities >1), and IGFBP5 (a = 3.22, 
      1.27, and 0.85 d for age at first farrowing and farrowing interval in the first
      and later parities, respectively). For the Landrace population, 6 markers were
      polymorphic, and significant effects were detected for traits affecting litter
      size. The polymorphism within the COX2 gene had an additive effect of 0.3 piglets
      for litter size in parities >1, and the IGFBP1 gene had an additive effect of
      0.21, 0.26, and 0.11 piglets for litter size in the first parity, parities >1,
      and stillborn in parities >1, respectively. The additive effect of the SNP within
      the IGFBP2 gene was 0.16, 0.09, and 0.09 piglets for litter size in parities >1
      and stillborn in the first and later parities, respectively. Finally, the IGFBP5 
      gene had an additive effect of 0.18, 0.07, and 0.07 piglets for litter size in
      the first parity, stillborn in parities >1, and mortality between farrowing and
      weaning in the first parity, respectively. These results support the suitability 
      of the candidate gene approach for identification of markers to improve the
      reproductive performance of sows and to provide potential markers for
      marker-assisted selection.
FAU - Sironen, A I
AU  - Sironen AI
AD  - Agrifood Research Finland, MTT, Biotechnology and Food Research, Genomics,
      FI-36100 Jokioinen, Finland. anu.sironen@mtt.fi
FAU - Uimari, P
AU  - Uimari P
FAU - Serenius, T
AU  - Serenius T
FAU - Mote, B
AU  - Mote B
FAU - Rothschild, M
AU  - Rothschild M
FAU - Vilkki, J
AU  - Vilkki J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091120
PL  - United States
TA  - J Anim Sci
JT  - Journal of animal science
JID - 8003002
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Alleles
MH  - Animals
MH  - Female
MH  - Fertility/genetics
MH  - Finland
MH  - Genes/genetics
MH  - Genetic Association Studies/veterinary
MH  - Genetic Markers/genetics
MH  - Genotype
MH  - Litter Size/genetics
MH  - Male
MH  - Parity/genetics
MH  - Phenotype
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Pregnancy/genetics
MH  - Reproduction/*genetics
MH  - Stillbirth/genetics/veterinary
MH  - Swine/*genetics/physiology
MH  - Weaning
EDAT- 2009/11/26 06:00
MHDA- 2010/05/18 06:00
CRDT- 2009/11/26 06:00
PHST- 2009/11/26 06:00 [entrez]
PHST- 2009/11/26 06:00 [pubmed]
PHST- 2010/05/18 06:00 [medline]
AID - jas.2009-2426 [pii]
AID - 10.2527/jas.2009-2426 [doi]
PST - ppublish
SO  - J Anim Sci. 2010 Mar;88(3):821-7. doi: 10.2527/jas.2009-2426. Epub 2009 Nov 20.


PMID- 19933354
OWN - NLM
STAT- MEDLINE
DCOM- 20100225
LR  - 20091218
IS  - 1049-7323 (Print)
IS  - 1049-7323 (Linking)
VI  - 20
IP  - 1
DP  - 2010 Jan
TI  - Research opportunities with curanderos to address childhood overweight in Latino 
      families.
PG  - 4-14
LID - 10.1177/1049732309355285 [doi]
AB  - Curanderos are consulted as an adjunct or alternative to biomedical health care
      in the greater southwest, although the extent of their involvement in obesity
      prevention and treatment is poorly understood. Seven curanderos participated in
      audiotaped interviews about their work with families and beliefs about childhood 
      feeding and overweight. Themes reflected curanderos' beliefs about their practice
      and childhood obesity. Curanderos approach their work as a calling, emphasizing
      elements from nature in etiology and cure. From the curandero's standpoint,
      essential elements of obesity management must acknowledge the socially
      marginalized experiences of Latinos. We encountered working with curanderos as
      problematic, and this likely reflected our differing personal characteristics and
      a tension between our healing professions. Curanderos could serve as
      collaborators in childhood obesity interventions if we craft health messages and 
      delivery modes that resonate with Latino families and address ethical and
      communication issues on the research team.
FAU - Clark, Lauren
AU  - Clark L
AD  - University of Utah College of Nursing, Salt Lake City, Utah 84112, USA.
      lauren.clark@nurs.utah.edu
FAU - Bunik, Maya
AU  - Bunik M
FAU - Johnson, Susan L
AU  - Johnson SL
LA  - eng
GR  - R03 NR008496/NR/NINR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20091120
PL  - United States
TA  - Qual Health Res
JT  - Qualitative health research
JID - 9202144
MH  - Anthropology, Cultural
MH  - Cultural Characteristics
MH  - Diet
MH  - Family Relations
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - *Medicine, Traditional
MH  - *Mexican Americans
MH  - Obesity/ethnology
MH  - Overweight/*ethnology
EDAT- 2009/11/26 06:00
MHDA- 2010/02/26 06:00
CRDT- 2009/11/26 06:00
PHST- 2009/11/26 06:00 [entrez]
PHST- 2009/11/26 06:00 [pubmed]
PHST- 2010/02/26 06:00 [medline]
AID - 1049732309355285 [pii]
AID - 10.1177/1049732309355285 [doi]
PST - ppublish
SO  - Qual Health Res. 2010 Jan;20(1):4-14. doi: 10.1177/1049732309355285. Epub 2009
      Nov 20.


PMID- 19933288
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20161125
IS  - 1532-2114 (Electronic)
IS  - 1532-2114 (Linking)
VI  - 11
IP  - 2
DP  - 2010 Mar
TI  - An ethical dilemma: severe ischaemic mitral regurgitation and acute coronary
      syndrome in a 49-year-old pregnant woman.
PG  - 195-7
LID - 10.1093/ejechocard/jep180 [doi]
AB  - We report the case of a 49-year-old woman who presented with symptomatic severe
      mitral regurgitation secondary to previous myocardial infarction. During the
      work-up for surgery, she was found to be pregnant. This report explores the
      difficulties and ethical dilemmas encountered dealing with the need for urgent
      valve surgery and coronary revascularization in association with an unplanned,
      but wanted pregnancy in an older woman.
FAU - Herrey, Anna S
AU  - Herrey AS
AD  - Department of Cardiology, Hammersmith Hospital, Imperial College Healthcare NHS
      Trust, Du Cane Road, London, UK. anna.john@doctors.org.uk
FAU - Germain, Sarah J
AU  - Germain SJ
FAU - Nelson-Piercy, Catherine
AU  - Nelson-Piercy C
FAU - Kaprielian, Raffi R
AU  - Kaprielian RR
FAU - Bennett, Phillip
AU  - Bennett P
FAU - Punjabi, Prakash P
AU  - Punjabi PP
FAU - Nihoyannopoulos, Petros
AU  - Nihoyannopoulos P
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20091120
PL  - England
TA  - Eur J Echocardiogr
JT  - European journal of echocardiography : the journal of the Working Group on
      Echocardiography of the European Society of Cardiology
JID - 100890618
RN  - 0 (Platelet Aggregation Inhibitors)
SB  - IM
MH  - *Abortion, Therapeutic
MH  - Acute Coronary Syndrome/*diagnostic imaging/therapy
MH  - Angioplasty, Balloon, Coronary
MH  - Echocardiography
MH  - *Ethics, Medical
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Mitral Valve Insufficiency/*diagnostic imaging/therapy
MH  - Myocardial Ischemia/*diagnostic imaging/therapy
MH  - Platelet Aggregation Inhibitors/therapeutic use
MH  - Pregnancy
MH  - Pregnancy Complications
EDAT- 2009/11/26 06:00
MHDA- 2011/06/03 06:00
CRDT- 2009/11/26 06:00
PHST- 2009/11/26 06:00 [entrez]
PHST- 2009/11/26 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
AID - jep180 [pii]
AID - 10.1093/ejechocard/jep180 [doi]
PST - ppublish
SO  - Eur J Echocardiogr. 2010 Mar;11(2):195-7. doi: 10.1093/ejechocard/jep180. Epub
      2009 Nov 20.


PMID- 19932652
OWN - NLM
STAT- MEDLINE
DCOM- 20100406
LR  - 20181201
IS  - 1879-3479 (Electronic)
IS  - 0020-7292 (Linking)
VI  - 108
IP  - 2
DP  - 2010 Feb
TI  - Brain drain of healthcare workers: FIGO Committee for the Ethical Aspects of
      Human Reproduction and Women's Health.
PG  - 174-5
LID - 10.1016/j.ijgo.2009.10.001 [doi]
LA  - eng
PT  - Journal Article
DEP - 20091122
PL  - United States
TA  - Int J Gynaecol Obstet
JT  - International journal of gynaecology and obstetrics: the official organ of the
      International Federation of Gynaecology and Obstetrics
JID - 0210174
SB  - IM
MH  - *Developing Countries
MH  - *Emigration and Immigration
MH  - Female
MH  - *Health Planning Guidelines
MH  - Health Workforce/*ethics
MH  - Humans
MH  - Pregnancy
MH  - *Reproductive Medicine
MH  - Women's Health/ethics
EDAT- 2009/11/26 06:00
MHDA- 2010/04/07 06:00
CRDT- 2009/11/26 06:00
PHST- 2009/11/26 06:00 [entrez]
PHST- 2009/11/26 06:00 [pubmed]
PHST- 2010/04/07 06:00 [medline]
AID - S0020-7292(09)00578-5 [pii]
AID - 10.1016/j.ijgo.2009.10.001 [doi]
PST - ppublish
SO  - Int J Gynaecol Obstet. 2010 Feb;108(2):174-5. doi: 10.1016/j.ijgo.2009.10.001.
      Epub 2009 Nov 22.


PMID- 19932548
OWN - NLM
STAT- MEDLINE
DCOM- 20100302
LR  - 20151119
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 70
IP  - 4
DP  - 2010 Feb
TI  - Physicians' psychosocial barriers to different modes of withdrawal of life
      support in critical care: A qualitative study in Japan.
PG  - 616-22
LID - 10.1016/j.socscimed.2009.10.036 [doi]
AB  - Despite a number of guidelines issued in Anglo-American countries over the past
      few decades for forgoing treatment stating that there is no ethically relevant
      difference between withholding and withdrawing life-sustaining treatments (LST), 
      it is recognized that many healthcare professionals in Japan as well as some of
      their western counterparts do not agree with this statement. This research was
      conducted to investigate the barriers that prevent physicians from withdrawing
      specific LST in critical care settings, focusing mainly on the modes of
      withdrawal of LST, in what the authors believe was the first study of its kind
      anywhere in the world. In 2006-2007, in-depth, face-to-face, semistructured
      interviews were conducted with 35 physicians working at emergency and critical
      care facilities across Japan. We elicited their experiences, attitudes, and
      perceptions regarding withdrawal of mechanical ventilation and other LST. The
      process of data analysis followed the grounded theory approach. We found that the
      psychosocial resistance of physicians to withdrawal of artificial devices varied 
      according to the modes of withdrawal, showing a strong resistance to withdrawal
      of mechanical ventilation that requires physicians to halt the treatment when
      continuation of its mechanical operation is possible. However, there was little
      resistance to the withdrawal of percutaneous cardiopulmonary support and
      artificial liver support when their continuation was mechanically or
      physiologically impossible. The physicians shared a desire for a "soft landing"
      of the patient, that is, a slow and gradual death without drastic and immediate
      changes, which serves the psychosocial needs of the people surrounding the
      patient. For that purpose, vasopressors were often withheld and withdrawn. The
      findings suggest what the Japanese physicians avoid is not what they call a
      life-shortening act but an act that would not lead to a soft landing, or a slow
      death that looks 'natural' in the eyes of those surrounding the patient. The
      purpose of constructing such a final scene is believed to fulfill the
      psychosocial needs of the patient's family and the physicians, who emphasize on
      how death feels to those surrounding the patient. Unless withdrawing LST would
      lead to a soft landing, Japanese clinicians, who recognize that the results of
      withdrawing LST affect not only the patient but those around the patient, are
      likely to feel that there is an ethically relevant difference between withholding
      and withdrawing LST.
CI  - Copyright 2009 Elsevier Ltd. All rights reserved.
FAU - Aita, Kaoruko
AU  - Aita K
AD  - The University of Tokyo, Graduate School of Humanities and Sociology, Global COE 
      Programme Death and Life Studies, 7-3-1 Hongo, Bunkyo-ku, Tokyo113-0033, Japan.
      aitak-tky@umin.ac.jp
FAU - Kai, Ichiro
AU  - Kai I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091122
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Attitude of Health Personnel
MH  - Critical Care/*ethics
MH  - Female
MH  - Humans
MH  - Interviews as Topic
MH  - Japan
MH  - *Life Support Care/ethics
MH  - Male
MH  - Middle Aged
MH  - Physicians/*psychology
MH  - Practice Patterns, Physicians'
MH  - Professional-Family Relations
MH  - Qualitative Research
MH  - Social Values
MH  - *Withholding Treatment/ethics
EDAT- 2009/11/26 06:00
MHDA- 2010/03/03 06:00
CRDT- 2009/11/26 06:00
PHST- 2009/02/12 00:00 [received]
PHST- 2009/11/26 06:00 [entrez]
PHST- 2009/11/26 06:00 [pubmed]
PHST- 2010/03/03 06:00 [medline]
AID - S0277-9536(09)00726-6 [pii]
AID - 10.1016/j.socscimed.2009.10.036 [doi]
PST - ppublish
SO  - Soc Sci Med. 2010 Feb;70(4):616-22. doi: 10.1016/j.socscimed.2009.10.036. Epub
      2009 Nov 22.


PMID- 19931963
OWN - NLM
STAT- MEDLINE
DCOM- 20100302
LR  - 20151119
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 70
IP  - 4
DP  - 2010 Feb
TI  - Perceptions of the gift relationship in organ and tissue donation: Views of
      intensivists and donor and recipient coordinators.
PG  - 609-15
LID - 10.1016/j.socscimed.2009.10.062 [doi]
AB  - The international literature on organ donation and transplantation has drawn
      attention to the popularity of "gift of life" discourse among pro-donation
      advocates, transplantation specialists, and within organisations lobbying for
      improved donation rates to promote the benefits of organ donation among members
      of the general public. In Aotearoa/New Zealand, gift of life discourse is robust.
      Aside from attempts to elicit altruism by promoting tissue donation in the public
      domain, gift terminology separates the act of donation from that of commerce and 
      the commodification of body tissues. In distancing donation from commodification 
      and the potential to degrade and exploit human beings, it is assumed that gift
      discourse transmits the positive message that donation is a noble and morally
      worthy act. Recent sociological research has shown that assumptions of the gift
      as one-way and altruistic do not necessarily align with people's perceptions and 
      experience of donating body tissues, and that the vocabulary used to describe
      these acts is often at variance with reality. This article draws on interview
      data with 15 critical care specialists (intensivists) and donor and recipient
      coordinators, examining their perceptions of the relevance of gift discourse and 
      its applicability in the context of deceased donation in Aotearoa/New Zealand.
      The data indicate several problems with gift rhetoric to describe the situations 
      health professionals encounter. In sum, gift terminology tends to downplay the
      sacrifice involved in tissue donation generally, as well as depoliticising the
      exchange relations of tissue transfer in contemporary consumer culture and in the
      global context. This raises questions about the underlying ethics of language
      choice and what, if anything, empirical accounts of tissue transfer can
      contribute to ethical debates.
CI  - Copyright 2009 Elsevier Ltd. All rights reserved.
FAU - Shaw, Rhonda
AU  - Shaw R
AD  - Sociology/Social Policy, Victoria University of Wellington, PO Box 600,
      Wellington, New Zealand. rhonda.shaw@vuw.ac.nz
LA  - eng
PT  - Journal Article
DEP - 20091120
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Altruism
MH  - *Attitude of Health Personnel
MH  - Critical Care
MH  - *Gift Giving
MH  - Humans
MH  - Interviews as Topic
MH  - New Zealand
MH  - Persuasive Communication
MH  - *Terminology as Topic
MH  - Third-Party Consent
MH  - *Tissue and Organ Procurement/ethics/organization & administration
EDAT- 2009/11/26 06:00
MHDA- 2010/03/03 06:00
CRDT- 2009/11/26 06:00
PHST- 2009/06/13 00:00 [received]
PHST- 2009/07/25 00:00 [revised]
PHST- 2009/10/21 00:00 [accepted]
PHST- 2009/11/26 06:00 [entrez]
PHST- 2009/11/26 06:00 [pubmed]
PHST- 2010/03/03 06:00 [medline]
AID - S0277-9536(09)00771-0 [pii]
AID - 10.1016/j.socscimed.2009.10.062 [doi]
PST - ppublish
SO  - Soc Sci Med. 2010 Feb;70(4):609-15. doi: 10.1016/j.socscimed.2009.10.062. Epub
      2009 Nov 20.


PMID- 19930416
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20151119
IS  - 1399-0004 (Electronic)
IS  - 0009-9163 (Linking)
VI  - 77
IP  - 4
DP  - 2010 Apr
TI  - Treatment-focused DNA testing for newly diagnosed breast cancer patients: some
      implications for clinical practice.
PG  - 350-4
LID - 10.1111/j.1399-0004.2009.01307.x [doi]
AB  - There is accumulating evidence that women with breast cancer due to a familial
      BRCA1 or BRCA2 mutation benefit from specific surgical and chemotherapeutic
      treatment strategies. However, the rapid identification of such patients during
      the acute phase of treatment raises a number of issues. This study investigated
      Australian opinion leaders' views on the issues arising from such
      'treatment-focused' genetic testing. Semi-structured interviews with 34 opinion
      leaders working in cancer genetics were undertaken. Interviewees acknowledged the
      introduction of treatment-focused DNA testing has the potential to positively
      transform the management of breast cancer patients, but were concerned that
      certain ethical and logistical issues have yet to be addressed. These include
      decision-making and consent, the familial nature of genetic information, and the 
      management of genetics services within familial cancer clinics in the public
      hospital system in Australia. Service providers will need to have policies and
      strategies for managing the increased demand. It will also be necessary to
      include genetic counseling services within familial cancer clinics in the care
      pathway for newly diagnosed patients prior to any DNA testing to determine
      adjuvant treatment; such services may be more cost-effective than expecting
      surgeons and medical oncologists to fulfill this role.
FAU - Lobb, E A
AU  - Lobb EA
AD  - Calvary Health Care Sydney, Kogarah, New South Wales, Australia.
      Liz.Lobb@sesiahs.health.nsw.gov.au
FAU - Barlow-Stewart, K
AU  - Barlow-Stewart K
FAU - Suthers, G
AU  - Suthers G
FAU - Hallowell, N
AU  - Hallowell N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091123
PL  - Denmark
TA  - Clin Genet
JT  - Clinical genetics
JID - 0253664
RN  - 0 (DNA, Neoplasm)
SB  - IM
MH  - Australia
MH  - Breast Neoplasms/*diagnosis/genetics/*therapy
MH  - DNA, Neoplasm/*analysis/*genetics
MH  - Decision Making
MH  - Family
MH  - Female
MH  - Genetic Testing/*methods/organization & administration
MH  - Humans
MH  - Informed Consent
MH  - *Practice Patterns, Physicians'/organization & administration
EDAT- 2009/11/26 06:00
MHDA- 2010/09/15 06:00
CRDT- 2009/11/26 06:00
PHST- 2009/11/26 06:00 [entrez]
PHST- 2009/11/26 06:00 [pubmed]
PHST- 2010/09/15 06:00 [medline]
AID - CGE1307 [pii]
AID - 10.1111/j.1399-0004.2009.01307.x [doi]
PST - ppublish
SO  - Clin Genet. 2010 Apr;77(4):350-4. doi: 10.1111/j.1399-0004.2009.01307.x. Epub
      2009 Nov 23.


PMID- 19930112
OWN - NLM
STAT- MEDLINE
DCOM- 20100812
LR  - 20171116
IS  - 1526-4637 (Electronic)
IS  - 1526-2375 (Linking)
VI  - 11
IP  - 2
DP  - 2010 Feb
TI  - American academy of pain medicine ethics council statement on conflicts of
      interest: interaction between physicians and industry in pain medicine.
PG  - 257-62
LID - 10.1111/j.1526-4637.2009.00739.x [doi]
AB  - New concerns have appeared recently in regard to the increasingly complex
      relationship between physicians and the pharmaceutical or devices industry. The
      American Academy of Pain Medicine (AAPM) Council on Ethics has discussed the
      issue, especially focusing on the implication of conflicts of interest for Pain
      Medicine, and published several recommendations for specific professional
      situations that the Pain Medicine physician may encounter.
FAU - Dubois, Michel Y
AU  - Dubois MY
AD  - Pain Management Center, New York University, New York, New York, USA.
      Michel.Dubois@nyumc.org
CN  - American Academy of Pain Medicine Ethics Council
LA  - eng
PT  - Guideline
PT  - Journal Article
DEP - 20091117
PL  - England
TA  - Pain Med
JT  - Pain medicine (Malden, Mass.)
JID - 100894201
RN  - 0 (Analgesics)
SB  - IM
MH  - Analgesics
MH  - Bias
MH  - *Conflict of Interest
MH  - Drug Industry/*ethics
MH  - Education, Medical, Continuing/ethics
MH  - Equipment and Supplies/ethics
MH  - *Ethics, Medical
MH  - Marketing of Health Services/ethics
MH  - *Pain
MH  - Physicians/*ethics
MH  - Research Support as Topic/ethics
MH  - Societies, Medical
EDAT- 2009/11/26 06:00
MHDA- 2010/08/13 06:00
CRDT- 2009/11/26 06:00
PHST- 2009/11/26 06:00 [entrez]
PHST- 2009/11/26 06:00 [pubmed]
PHST- 2010/08/13 06:00 [medline]
AID - PME739 [pii]
AID - 10.1111/j.1526-4637.2009.00739.x [doi]
PST - ppublish
SO  - Pain Med. 2010 Feb;11(2):257-62. doi: 10.1111/j.1526-4637.2009.00739.x. Epub 2009
      Nov 17.


PMID- 19929226
OWN - NLM
STAT- MEDLINE
DCOM- 20100427
LR  - 20100129
IS  - 1557-7740 (Electronic)
IS  - 1557-7740 (Linking)
VI  - 13
IP  - 2
DP  - 2010 Feb
TI  - What should we say when discussing "code status" and life support with a patient?
      A Delphi analysis.
PG  - 185-95
LID - 10.1089/jpm.2009.0269 [doi]
AB  - BACKGROUND: Patients and clinicians often find it difficult to discuss wishes
      regarding cardiopulmonary resuscitation (CPR) or "code status." Some authors have
      published effective communication styles, but there are currently no published
      guidelines for the content of a discussion about resuscitation or goals of care. 
      METHODS: We identified a group of physicians with expertise in end-of-life care
      and communication, and used the Delphi method to develop a series of consensus
      statements about the ideal content of a discussion of CPR and goals of care.
      RESULTS: Twelve physicians agreed to participate in the study, generating nine
      consensus statements. These statements addressed the following topics: timing the
      discussion; framing the discussion in terms of "goals of care"; distinguishing
      between life-sustaining therapy (LST) and CPR; describing a cardiac arrest, LST, 
      CPR, and palliative care; describing what happens after a cardiac arrest; how to 
      modify the discussion to respect a patient's medical condition or beliefs;
      offering a prognosis; making a recommendation; and the importance of trust and
      rapport. There was consensus for each statement after the second Delphi round.
      INTERPRETATION: Physicians with expertise in end-of-life care and communication
      were able to develop consensus statements for the ideal content of a discussion
      of CPR and goals of care. These statements can serve as guidelines for physicians
      who feel uncomfortable with these discussions, in order to facilitate effective, 
      informed, and ethically sound decision making.
FAU - Downar, James
AU  - Downar J
AD  - Division of Palliative Care, Toronto General Hospital, Toronto, Ontario, Canada. 
      james.downar@utoronto.ca
FAU - Hawryluck, Laura
AU  - Hawryluck L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Palliat Med
JT  - Journal of palliative medicine
JID - 9808462
SB  - IM
MH  - Adult
MH  - *Cardiopulmonary Resuscitation
MH  - *Communication
MH  - Delphi Technique
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Patient Education as Topic
MH  - Physician-Patient Relations
MH  - *Resuscitation Orders
EDAT- 2009/11/26 06:00
MHDA- 2010/04/28 06:00
CRDT- 2009/11/26 06:00
PHST- 2009/11/26 06:00 [entrez]
PHST- 2009/11/26 06:00 [pubmed]
PHST- 2010/04/28 06:00 [medline]
AID - 10.1089/jpm.2009.0269 [doi]
PST - ppublish
SO  - J Palliat Med. 2010 Feb;13(2):185-95. doi: 10.1089/jpm.2009.0269.


PMID- 19926230
OWN - NLM
STAT- MEDLINE
DCOM- 20100507
LR  - 20140812
IS  - 1773-0430 (Electronic)
IS  - 0150-9918 (Linking)
VI  - 39
IP  - 1
DP  - 2010 Feb
TI  - [Female genital mutilation - the excision. Reflections of the ethics committee of
      the medical association Avicenne of France].
PG  - 81-2
LID - 10.1016/j.jgyn.2009.10.003 [doi]
FAU - Messaadi, N
AU  - Messaadi N
FAU - Chaker, A
AU  - Chaker A
LA  - fre
PT  - Letter
TT  - Mutilation genitale feminine - l'excision. Reflexions du comite d'ethique de
      l'association medicale Avicenne de France (AMAF).
DEP - 20091118
PL  - France
TA  - J Gynecol Obstet Biol Reprod (Paris)
JT  - Journal de gynecologie, obstetrique et biologie de la reproduction
JID - 0322206
SB  - IM
MH  - Circumcision, Female/*ethics/*methods
MH  - *Ethics Committees
MH  - Female
MH  - France
MH  - Humans
MH  - Islam
MH  - *Women's Rights
EDAT- 2009/11/21 06:00
MHDA- 2010/05/08 06:00
CRDT- 2009/11/21 06:00
PHST- 2009/10/07 00:00 [received]
PHST- 2009/10/12 00:00 [accepted]
PHST- 2009/11/21 06:00 [entrez]
PHST- 2009/11/21 06:00 [pubmed]
PHST- 2010/05/08 06:00 [medline]
AID - S0368-2315(09)00289-0 [pii]
AID - 10.1016/j.jgyn.2009.10.003 [doi]
PST - ppublish
SO  - J Gynecol Obstet Biol Reprod (Paris). 2010 Feb;39(1):81-2. doi:
      10.1016/j.jgyn.2009.10.003. Epub 2009 Nov 18.


PMID- 19925271
OWN - NLM
STAT- MEDLINE
DCOM- 20100504
LR  - 20151119
IS  - 0963-8288 (Print)
IS  - 0963-8288 (Linking)
VI  - 32
IP  - 1
DP  - 2010
TI  - Dignity not fully upheld when seeking health care: experiences expressed by
      individuals suffering from Ehlers-Danlos syndrome.
PG  - 1-7
LID - 10.3109/09638280903178407 [doi]
AB  - AIM: The principle of human dignity has assumed importance in ethics and
      constitutional law throughout the 20th century in the Western world. It calls for
      respect of each individual as unique, and of treating him or her as a subject,
      never as a mere object. As such, the principle constitutes an ethical cornerstone
      in health care. Patients suffering from Ehlers-Danlos syndrome (EDS) challenge
      medical care and knowledge in health-care professionals' as symptoms sometimes
      are vague. Individuals with this disorder have reported not being respected when 
      seeking health care. PURPOSE: To describe encounters in health-care situations
      when individuals suffering from EDS experienced that their dignity was not fully 
      upheld. A further aim was to describe the long-term consequences of these
      experiences. METHOD: A study-specific questionnaire was designed, where
      individuals with EDS described their encounters with health care from a personal 
      perspective. RESULTS: After qualitative content analysis, the following five
      categories were identified: 'Being ignored and belittled by health-care
      professionals,' 'Being assigned psychological and/or psychiatric explanations',
      'Being treated and considered merely as an object', 'Being trespassed in one's
      personal sphere' and 'Being suspected of family violence'. Consequences of these 
      encounters were 'Mistrusting the physician' and 'Risking bad health'.
      CONCLUSIONS: The memory of not being respected is substantial for individuals
      with EDS and can last for years. As a result, lack of trust for the health-care
      system is created and they may experience difficulties in future encounters with 
      health care. Therefore, health-care professionals should base their actions on
      norms that protect human dignity and confirm each patient as a unique human being
      with resources and abilities to master their own life.
FAU - Berglund, Britta
AU  - Berglund B
AD  - Nursing Division, Department of Medical and Surgical Gastroenterology, Karolinska
      University Hospital, SE-141 86 Stockholm, Sweden. britta.berglund@karolinska.se
FAU - Anne-Cathrine, Mattiasson
AU  - Anne-Cathrine M
FAU - Randers, Ingrid
AU  - Randers I
LA  - eng
PT  - Journal Article
PL  - England
TA  - Disabil Rehabil
JT  - Disability and rehabilitation
JID - 9207179
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Attitude of Health Personnel
MH  - Ehlers-Danlos Syndrome/*psychology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Patient Acceptance of Health Care
MH  - *Patient Rights
MH  - *Personhood
MH  - *Physician-Patient Relations
MH  - Quality of Health Care
MH  - Surveys and Questionnaires
EDAT- 2009/11/21 06:00
MHDA- 2010/05/05 06:00
CRDT- 2009/11/21 06:00
PHST- 2009/11/21 06:00 [entrez]
PHST- 2009/11/21 06:00 [pubmed]
PHST- 2010/05/05 06:00 [medline]
AID - 10.3109/09638280903178407 [doi]
PST - ppublish
SO  - Disabil Rehabil. 2010;32(1):1-7. doi: 10.3109/09638280903178407.


PMID- 19924734
OWN - NLM
STAT- MEDLINE
DCOM- 20100309
LR  - 20211028
IS  - 1097-0223 (Electronic)
IS  - 0197-3851 (Linking)
VI  - 30
IP  - 1
DP  - 2010 Jan
TI  - Ambivalence toward undergoing invasive prenatal testing: an exploration of its
      origins.
PG  - 77-82
LID - 10.1002/pd.2343 [doi]
AB  - OBJECTIVE: This study explores ambivalence toward undergoing amniocentesis among 
      pregnant women with overall positive attitudes. Its novelty lies in the
      characterization of the type and origins of the ambivalence. METHOD: Thirty-six
      women between 35 and 44 years of age were recruited from a US prenatal testing
      center to participate in structured telephone interviews. RESULTS: Thirty women
      chose to undergo testing. Attitudes toward undergoing amniocentesis were
      generally positive, although all participants simultaneously described feeling
      ambivalent. The women desired the information that amniocentesis could provide
      yet did not want to place their fetus at risk. Participants cited religious,
      moral, ethical and intellectual values important in shaping their attitudes
      toward undergoing amniocentesis. Important referents such as partners, other
      pregnant women, family members and physicians influenced their decisions.
      CONCLUSION: Tensions were evident among the intellectual, moral and spiritual
      values that contribute to ambivalence toward undergoing amniocentesis.
      Illuminating and discussing such tensions during the genetic counseling sessions 
      prior to testing may resolve some of this ambivalence and thereby increase the
      quality of decisions women make.
CI  - Copyright (c) 2009 John Wiley & Sons, Ltd.
FAU - Sapp, Julie Chevalier
AU  - Sapp JC
AD  - Genetic Diseases Research Branch, National Human Genome Research Institute, 10
      Center Drive, Bethesda, MD 20892, USA. sappj@mail.nih.gov
FAU - Hull, Sara Chandros
AU  - Hull SC
FAU - Duffer, Shelby
AU  - Duffer S
FAU - Zornetzer, Sarah
AU  - Zornetzer S
FAU - Sutton, Erica
AU  - Sutton E
FAU - Marteau, Theresa M
AU  - Marteau TM
FAU - Biesecker, Barbara Bowles
AU  - Biesecker BB
LA  - eng
GR  - Z99 HG999999/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PL  - England
TA  - Prenat Diagn
JT  - Prenatal diagnosis
JID - 8106540
SB  - IM
MH  - Adult
MH  - Amniocentesis/adverse effects/*psychology
MH  - *Attitude to Health
MH  - *Choice Behavior
MH  - Female
MH  - *Health Behavior
MH  - Humans
MH  - Interviews as Topic
MH  - Pregnancy
MH  - Risk Assessment
PMC - PMC2880848
MID - NIHMS204771
EDAT- 2009/11/20 06:00
MHDA- 2010/03/10 06:00
CRDT- 2009/11/20 06:00
PHST- 2009/11/20 06:00 [entrez]
PHST- 2009/11/20 06:00 [pubmed]
PHST- 2010/03/10 06:00 [medline]
AID - 10.1002/pd.2343 [doi]
PST - ppublish
SO  - Prenat Diagn. 2010 Jan;30(1):77-82. doi: 10.1002/pd.2343.


PMID- 19924645
OWN - NLM
STAT- MEDLINE
DCOM- 20100126
LR  - 20181201
IS  - 1699-5848 (Electronic)
IS  - 0213-3911 (Linking)
VI  - 25
IP  - 1
DP  - 2010 Jan
TI  - The amniotic membrane as a source of stem cells.
PG  - 91-8
LID - 10.14670/HH-25.91 [doi]
AB  - Cellular therapy has emerged as a new potential tool for curing a wide range of
      degenerative diseases and tissue necrosis. Embryonic stem cells possess potential
      for differentiation into a wide range of cell lineages, but the ethical issues
      associated with establishment of this human cell line have to be resolved prior
      to any use. The bone marrow (BM) is the usual source of adult stem cells for
      hematopoietic stem cell transplants and cellular therapy, but the BM harvest is a
      surgical procedure that requires general anesthesia or sedation, and there seems 
      to be a reduction of the proliferative potential and differentiation capacity of 
      the marrow mesenchymal stem cells in older donors. For these reasons there is an 
      increasing interest in other sources of stem cells from adult and fetal tissues. 
      The amniotic membrane (AM) or amnion is a tissue of particular interest because
      its cells possess characteristics of stem cells with multipotent differentiation 
      ability, and because of low immunogenicity and easy procurement from the
      placenta, which is a discarded tissue after parturition, thus avoiding the
      current controversies associated with the use of human embryonic stem cells.
      Therefore, amniotic membrane has been proposed as a good candidate to be used in 
      cellular therapy and regenerative medicine.
FAU - Insausti, Carmen L
AU  - Insausti CL
AD  - Hematology Department, Cellular Therapy Unit, University Hospital Virgen de la
      Arrixaca, Ctra Madrid-Cartagena, El Palmar, Murcia, Spain.
FAU - Blanquer, Miguel
AU  - Blanquer M
FAU - Bleda, Patricia
AU  - Bleda P
FAU - Iniesta, Paqui
AU  - Iniesta P
FAU - Majado, Maria J
AU  - Majado MJ
FAU - Castellanos, Gregorio
AU  - Castellanos G
FAU - Moraleda, Jose M
AU  - Moraleda JM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Spain
TA  - Histol Histopathol
JT  - Histology and histopathology
JID - 8609357
SB  - IM
MH  - Adult
MH  - Amnion/anatomy & histology/*cytology
MH  - Animals
MH  - Epithelial Cells/physiology
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Mesenchymal Stem Cells/physiology
MH  - Placenta/anatomy & histology/cytology
MH  - Pregnancy
MH  - Stem Cells/*physiology
MH  - Stromal Cells/physiology
RF  - 35
EDAT- 2009/11/20 06:00
MHDA- 2010/01/27 06:00
CRDT- 2009/11/20 06:00
PHST- 2009/11/20 06:00 [entrez]
PHST- 2009/11/20 06:00 [pubmed]
PHST- 2010/01/27 06:00 [medline]
AID - 10.14670/HH-25.91 [doi]
PST - ppublish
SO  - Histol Histopathol. 2010 Jan;25(1):91-8. doi: 10.14670/HH-25.91.


PMID- 19923034
OWN - NLM
STAT- MEDLINE
DCOM- 20110119
LR  - 20220321
IS  - 1872-7565 (Electronic)
IS  - 0169-2607 (Linking)
VI  - 99
IP  - 1
DP  - 2010 Jul
TI  - Finite element modelling of paediatric head impact: global validation against
      experimental data.
PG  - 25-33
LID - 10.1016/j.cmpb.2009.10.004 [doi]
AB  - Biomechanics of the human head has been widely studied for several decades. At a 
      mechanical level, the use of engineering and finite element (FE) methods has
      allowed injury mechanisms to be investigated using biofidelic FE models. These
      models are generally validated using experimental data then used to simulate
      real-world head trauma in order to derive numerical tolerance limits, leading to 
      efficient injury predicting tools. Due to ethical issues, experimental tests on
      the paediatric population remain prohibitive so direct validations of numerical
      models cannot be performed. However injury biomechanics on paediatric population 
      is emerging with experimental tests on the paediatric cadavers or tests on
      biological tissue and the development of finite element models. The present paper
      proposes a new finite element model of a newborn head, simulating its main
      features, with material properties from the literature. Global validation of the 
      model against experimental data in terms of skull deflection is performed and the
      model is used to simulate paediatric skull fracture coming from real-world head
      trauma.
CI  - Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
FAU - Roth, Sebastien
AU  - Roth S
AD  - Universite de Strasbourg, Institut de Mecanique des Fluides et des Solides, UDS
      CNRS, Strasbourg, France. sebastien.roth@utbm.fr
FAU - Raul, Jean-Sebastien
AU  - Raul JS
FAU - Willinger, Remy
AU  - Willinger R
LA  - eng
PT  - Journal Article
PT  - Validation Study
DEP - 20091117
PL  - Ireland
TA  - Comput Methods Programs Biomed
JT  - Computer methods and programs in biomedicine
JID - 8506513
SB  - IM
MH  - Biomechanical Phenomena
MH  - Craniocerebral Trauma/diagnostic imaging/etiology/*pathology
MH  - *Finite Element Analysis
MH  - Head/*anatomy & histology/pathology
MH  - Humans
MH  - Infant, Newborn
MH  - Models, Anatomic
MH  - Radiography
EDAT- 2009/11/20 06:00
MHDA- 2011/01/20 06:00
CRDT- 2009/11/20 06:00
PHST- 2009/02/13 00:00 [received]
PHST- 2009/10/14 00:00 [revised]
PHST- 2009/10/15 00:00 [accepted]
PHST- 2009/11/20 06:00 [entrez]
PHST- 2009/11/20 06:00 [pubmed]
PHST- 2011/01/20 06:00 [medline]
AID - S0169-2607(09)00288-0 [pii]
AID - 10.1016/j.cmpb.2009.10.004 [doi]
PST - ppublish
SO  - Comput Methods Programs Biomed. 2010 Jul;99(1):25-33. doi:
      10.1016/j.cmpb.2009.10.004. Epub 2009 Nov 17.


PMID- 19922751
OWN - NLM
STAT- MEDLINE
DCOM- 20100517
LR  - 20100226
IS  - 1872-8294 (Electronic)
IS  - 0169-409X (Linking)
VI  - 62
IP  - 4-5
DP  - 2010 Mar 18
TI  - Nano-microbicides: challenges in drug delivery, patient ethics and intellectual
      property in the war against HIV/AIDS.
PG  - 532-46
LID - 10.1016/j.addr.2009.11.022 [doi]
AB  - As we continue to be embroiled in the global battle against the human
      immunodeficiency virus (HIV), there has been an ongoing evolution in the
      understanding of the molecular mode of sexual transmission of HIV. This has gone 
      hand-in-hand with a paradigm shift and research focus on the development of
      microbicides - compounds designed for vaginal (and possibly rectal)
      administration that are envisaged to put safe, affordable and accessible
      protection into the hands of women. However, an effective microbicide is not yet 
      available; innovative approaches for the design of topical vaginal microbicides
      are urgently needed. The potential of the advancing field of nanomedicine has
      been earmarked in the increasing efforts to address the major health problems of 
      the developing world. In this review, advances in the design of innovative
      microbicide nanocarriers and nano-enabled microbicides, henceforth referred to as
      'nano-microbicides', are presented; elaborating on nanotechnology's role in the
      antiviral arena. The role of nanotechnology in the antiviral arena and the unique
      issues facing the generation of intellectual property relating to
      nano-microbicides in the ongoing global 'tug-of-war' of 'patients versus patents'
      are also explicated.
CI  - Copyright 2009 Elsevier B.V. All rights reserved.
FAU - du Toit, Lisa C
AU  - du Toit LC
AD  - University of the Witwatersrand, Department of Pharmacy and Pharmacology,
      Johannesburg, South Africa.
FAU - Pillay, Viness
AU  - Pillay V
FAU - Choonara, Yahya E
AU  - Choonara YE
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20091114
PL  - Netherlands
TA  - Adv Drug Deliv Rev
JT  - Advanced drug delivery reviews
JID - 8710523
RN  - 0 (Anti-HIV Agents)
RN  - 0 (Excipients)
SB  - IM
MH  - Anti-HIV Agents/*administration & dosage/*therapeutic use
MH  - Developing Countries
MH  - Drug Delivery Systems/*ethics/*trends
MH  - Excipients
MH  - HIV Infections/*drug therapy
MH  - HIV-1/drug effects/ultrastructure
MH  - Humans
MH  - *Intellectual Property
MH  - Nanoparticles
MH  - Nanotechnology/*education/trends
MH  - Patents as Topic/*ethics
RF  - 109
EDAT- 2009/11/20 06:00
MHDA- 2010/05/18 06:00
CRDT- 2009/11/20 06:00
PHST- 2009/05/28 00:00 [received]
PHST- 2009/09/14 00:00 [accepted]
PHST- 2009/11/20 06:00 [entrez]
PHST- 2009/11/20 06:00 [pubmed]
PHST- 2010/05/18 06:00 [medline]
AID - S0169-409X(09)00363-9 [pii]
AID - 10.1016/j.addr.2009.11.022 [doi]
PST - ppublish
SO  - Adv Drug Deliv Rev. 2010 Mar 18;62(4-5):532-46. doi: 10.1016/j.addr.2009.11.022. 
      Epub 2009 Nov 14.


PMID- 19921081
OWN - NLM
STAT- MEDLINE
DCOM- 20100430
LR  - 20220310
IS  - 1433-3023 (Electronic)
IS  - 0937-3462 (Linking)
VI  - 21
IP  - 3
DP  - 2010 Mar
TI  - Factors used by female pelvic medicine and reconstructive surgery fellowship
      directors to select their fellows.
PG  - 349-52
LID - 10.1007/s00192-009-1038-z [doi]
AB  - INTRODUCTION AND HYPOTHESIS: We report the attributes of Female Pelvic Medicine
      and Reconstructive Surgery (FPM&RS) fellowship applicants that are most valued by
      fellowship program directors during the ranking process. METHODS: Anonymous
      questionnaires were filled out by FPM&RS fellowship program directors following
      the 2008 match. The survey was designed to assess the relative importance of
      various factors in the ranking of fellowship applicants. RESULTS: Surveys were
      sent to 67 program directors, and 21 completed the survey (31%). Items ranked as 
      the most important in the selection process were a high quality obstetrics and
      gynecology residency education (8.2+/-1.2), followed by clinical research
      experience (7.4+/-1.4). Ability to work well with staff and work ethic were
      considered to be the most important subjective criteria. CONCLUSIONS: Our results
      support anecdotal evidence that placed emphasis on research experience and
      interpersonal skills in the selection of FPM&RS fellows.
FAU - Muffly, Tyler M
AU  - Muffly TM
AD  - Department of Obstetrics and Gynecology, Cleveland Clinic Foundation, Cleveland, 
      OH, USA. mufflyt@ccf.org
FAU - Penick, Emily R
AU  - Penick ER
FAU - Tang, Fengming
AU  - Tang F
FAU - Bonham, Aaron J
AU  - Bonham AJ
FAU - Smith, Roger P
AU  - Smith RP
FAU - Hill, Richard F C
AU  - Hill RF
FAU - Blandon, Roberta E
AU  - Blandon RE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int Urogynecol J
JT  - International urogynecology journal
JID - 101567041
SB  - IM
MH  - *Choice Behavior
MH  - *Fellowships and Scholarships
MH  - Gynecologic Surgical Procedures/*education
MH  - Humans
EDAT- 2009/11/19 06:00
MHDA- 2010/05/01 06:00
CRDT- 2009/11/19 06:00
PHST- 2009/07/12 00:00 [received]
PHST- 2009/10/25 00:00 [accepted]
PHST- 2009/11/19 06:00 [entrez]
PHST- 2009/11/19 06:00 [pubmed]
PHST- 2010/05/01 06:00 [medline]
AID - 10.1007/s00192-009-1038-z [doi]
PST - ppublish
SO  - Int Urogynecol J. 2010 Mar;21(3):349-52. doi: 10.1007/s00192-009-1038-z.


PMID- 19919946
OWN - NLM
STAT- MEDLINE
DCOM- 20110404
LR  - 20220311
IS  - 1473-0480 (Electronic)
IS  - 0306-3674 (Linking)
VI  - 44
IP  - 1
DP  - 2010 Jan
TI  - Anabolic-androgenic steroid use among young male and female athletes: is the game
      to blame?
PG  - 26-31
LID - 10.1136/bjsm.2009.068924 [doi]
AB  - The use of anabolic-androgenic steroids (AAS) by young athletes has been a
      primary concern of sports governing bodies because of the implications for unfair
      advantage in performance and the potential for adverse side effects. Research
      over several decades indicated a lifetime prevalence of AAS use for adolescent
      males of 4-6% and for females of 1.5-3%, indicating a problem involving millions 
      of athletes and a potential epidemic of AAS-related pathologies. However, recent 
      studies have questioned the presumption that participation in organised sport is 
      the primary risk factor for AAS use in adolescents as well as the extant
      estimates of the magnitude of the problem. Increasing evidence indicates that AAS
      use is associated with non-athletes and is linked to a broader syndrome of
      problem behaviours rather than efforts to achieve sporting success, and that
      sports participation may be protective against AAS use. Moreover, employing
      lifetime prevalence to gauge AAS use limits accurate evaluation of the personal
      and public health risk as the majority of respondents are not habitual users.
      Previous studies may have also inflated prevalence values through ambiguously
      worded survey questions and other design flaws, and few data are available on
      actual dosages. Prevention efforts need to be focused beyond organised sport and 
      target the general adolescent population rather than athletes and should be
      founded on interventions with demonstrated efficacy for delinquent, antisocial
      and self-destructive behaviours rather than the ethical imperative of fair play.
FAU - Harmer, P A
AU  - Harmer PA
AD  - Department of Exercise Science, Willamette University, Salem, OR 97301, USA.
      pharmer@willamette.edu
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20091116
PL  - England
TA  - Br J Sports Med
JT  - British journal of sports medicine
JID - 0432520
RN  - 0 (Anabolic Agents)
RN  - 0 (Performance-Enhancing Substances)
SB  - IM
MH  - Adolescent
MH  - *Anabolic Agents
MH  - Attitude to Health
MH  - Doping in Sports/prevention & control/psychology/*statistics & numerical data
MH  - Female
MH  - Forecasting
MH  - Humans
MH  - Male
MH  - *Performance-Enhancing Substances
MH  - Self Concept
MH  - Young Adult
EDAT- 2009/11/19 06:00
MHDA- 2011/04/05 06:00
CRDT- 2009/11/19 06:00
PHST- 2009/11/19 06:00 [entrez]
PHST- 2009/11/19 06:00 [pubmed]
PHST- 2011/04/05 06:00 [medline]
AID - bjsm.2009.068924 [pii]
AID - 10.1136/bjsm.2009.068924 [doi]
PST - ppublish
SO  - Br J Sports Med. 2010 Jan;44(1):26-31. doi: 10.1136/bjsm.2009.068924. Epub 2009
      Nov 16.


PMID- 19919583
OWN - NLM
STAT- MEDLINE
DCOM- 20100222
LR  - 20091207
IS  - 1399-6576 (Electronic)
IS  - 0001-5172 (Linking)
VI  - 54
IP  - 1
DP  - 2010 Jan
TI  - Pandemic influenza: human rights, ethics and duty to treat.
PG  - 9-15
LID - 10.1111/j.1399-6576.2009.02163.x [doi]
AB  - The 2009 influenza A/H1N1 pandemic seems to be only moderately severe. In the
      future, a pandemic influenza with high lethality, such as the Spanish influenza
      in 1918-1919 or even worse, may emerge. In this kind of scenario, lethality rates
      ranging roughly from 2% to 30% have been proposed. Legal and ethical issues
      should be discussed before the incident. This article aims to highlight the
      legal, ethical and professional aspects that might be relevant to
      anaesthesiologists in the case of a high-lethality infectious disease such as a
      severe pandemic influenza. The epidemiology, the role of anaesthesiologists and
      possible threats to the profession and colleagueship within medical specialties
      relevant to anaesthesiologists are reviewed. During historical plague epidemics, 
      some doctors have behaved like 'deserters'. However, during the Spanish
      influenza, physicians remained at their jobs, although many perished. In surveys,
      more than half of the health-care workers have reported their willingness to work
      in the case of severe pandemics. Physicians have the same human rights as all
      citizens: they have to be effectively protected against infectious disease.
      However, they have a duty to treat. Fair and responsible colleagueship among the 
      diverse medical specialties should be promoted. Until disaster threatens
      humanity, volunteering to work during a pandemic might be the best way to ensure 
      that physicians and other health-care workers stay at their workplace. Broad
      discussion in society is needed.
FAU - Pahlman, I
AU  - Pahlman I
AD  - Faculty of Social Sciences, University of Kuopio, Kuopio, Finland.
FAU - Tohmo, H
AU  - Tohmo H
FAU - Gylling, H
AU  - Gylling H
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20091116
PL  - England
TA  - Acta Anaesthesiol Scand
JT  - Acta anaesthesiologica Scandinavica
JID - 0370270
SB  - IM
CIN - Acta Anaesthesiol Scand. 2010 Jan;54(1):3-5. PMID: 19961438
MH  - *Anesthesiology/ethics/legislation & jurisprudence
MH  - Attitude of Health Personnel
MH  - *Disease Outbreaks
MH  - Human Rights/*legislation & jurisprudence
MH  - Humanism
MH  - Humans
MH  - Influenza, Human/*epidemiology
MH  - *Physician's Role
MH  - Workplace
RF  - 66
EDAT- 2009/11/19 06:00
MHDA- 2010/02/23 06:00
CRDT- 2009/11/19 06:00
PHST- 2009/11/19 06:00 [entrez]
PHST- 2009/11/19 06:00 [pubmed]
PHST- 2010/02/23 06:00 [medline]
AID - AAS2163 [pii]
AID - 10.1111/j.1399-6576.2009.02163.x [doi]
PST - ppublish
SO  - Acta Anaesthesiol Scand. 2010 Jan;54(1):9-15. doi:
      10.1111/j.1399-6576.2009.02163.x. Epub 2009 Nov 16.


PMID- 19914694
OWN - NLM
STAT- MEDLINE
DCOM- 20100222
LR  - 20101118
IS  - 1527-9995 (Electronic)
IS  - 0090-4295 (Linking)
VI  - 75
IP  - 1
DP  - 2010 Jan
TI  - Gender identity in disorders of sex development: review article.
PG  - 153-9
LID - 10.1016/j.urology.2009.07.1286 [doi]
AB  - OBJECTIVES: Many concerns have been raised regarding the treatment and long-term 
      outcome of infants born with complex genital anomalies. Debate among clinicians, 
      psychologists, ethicists, and patient advocate groups regarding the optimal
      management of these individuals is ongoing. Although determining the most
      appropriate gender is a difficult task, this review will help clarify some of the
      issues at hand. METHODS: A literature review which addresses the challenges of
      advising families about gender identity in infants and children with disorders of
      sex development. RESULTS: The evidence for endocrine effects on neurobiological
      development with regard to sexual behavior is compelling, although the existing
      outcome studies are largely anecdotal and somewhat contradictory. CONCLUSIONS:
      Gender assignment in infants born with a disorder of sex development remains only
      one of the many difficult decisions faced by both the treatment team and the
      family. Improved long-term follow-up of these patients will provide much needed
      feedback on previous and contemporary management.
CI  - 2010 Elsevier Inc. All rights reserved.
FAU - Yang, Jennifer H
AU  - Yang JH
AD  - Division of Pediatric Urology, University of California, San Francisco Children's
      Hospital, San Francisco, California, USA. yangjh@urology.ucsf.edu
FAU - Baskin, Laurence S
AU  - Baskin LS
FAU - DiSandro, Michael
AU  - DiSandro M
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20091114
PL  - United States
TA  - Urology
JT  - Urology
JID - 0366151
SB  - IM
CIN - Urology. 2010 Jan;75(1):159-60; author reply 160. PMID: 20109712
MH  - Disorders of Sex Development/*psychology
MH  - Female
MH  - *Gender Identity
MH  - Humans
MH  - Infant
MH  - Male
RF  - 50
EDAT- 2009/11/17 06:00
MHDA- 2010/02/23 06:00
CRDT- 2009/11/17 06:00
PHST- 2009/02/20 00:00 [received]
PHST- 2009/06/29 00:00 [revised]
PHST- 2009/07/03 00:00 [accepted]
PHST- 2009/11/17 06:00 [entrez]
PHST- 2009/11/17 06:00 [pubmed]
PHST- 2010/02/23 06:00 [medline]
AID - S0090-4295(09)02378-4 [pii]
AID - 10.1016/j.urology.2009.07.1286 [doi]
PST - ppublish
SO  - Urology. 2010 Jan;75(1):153-9. doi: 10.1016/j.urology.2009.07.1286. Epub 2009 Nov
      14.


PMID- 19914020
OWN - NLM
STAT- MEDLINE
DCOM- 20100414
LR  - 20100201
IS  - 1872-7727 (Electronic)
IS  - 0720-048X (Linking)
VI  - 73
IP  - 1
DP  - 2010 Jan
TI  - Privacy and security in teleradiology.
PG  - 31-5
LID - 10.1016/j.ejrad.2009.10.018 [doi]
AB  - Teleradiology is probably the most successful eHealth service available today.
      Its business model is based on the remote transmission of radiological images
      (e.g. X-ray and CT-images) over electronic networks, and on the interpretation of
      the transmitted images for diagnostic purpose. Two basic service models are
      commonly used teleradiology today. The most common approach is based on the
      message paradigm (off-line model), but more developed teleradiology systems are
      based on the interactive use of PACS/RIS systems. Modern teleradiology is also
      more and more cross-organisational or even cross-border service between service
      providers having different jurisdictions and security policies. This paper
      defines the requirements needed to make different teleradiology models trusted.
      Those requirements include a common security policy that covers all partners and 
      entities, common security and privacy protection principles and requirements,
      controlled contracts between partners, and the use of security controls and tools
      that supporting the common security policy. The security and privacy protection
      of any teleradiology system must be planned in advance, and the necessary
      security and privacy enhancing tools should be selected (e.g. strong
      authentication, data encryption, non-repudiation services and audit-logs) based
      on the risk analysis and requirements set by the legislation. In any case the
      teleradiology system should fulfil ethical and regulatory requirements.
      Certification of the whole teleradiology service system including security and
      privacy is also proposed. In the future, teleradiology services will be an
      integrated part of pervasive eHealth. Security requirements for this environment 
      including dynamic and context aware security services are also discussed in this 
      paper.
CI  - Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
FAU - Ruotsalainen, Pekka
AU  - Ruotsalainen P
AD  - National Institute for Health and Welfare, Helsinki, Finland.
      pekka.ruotsalainen@THL.fi
LA  - eng
PT  - Journal Article
DEP - 20091113
PL  - Ireland
TA  - Eur J Radiol
JT  - European journal of radiology
JID - 8106411
SB  - IM
MH  - Computer Security/*standards
MH  - Confidentiality/*standards
MH  - Europe
MH  - Finland
MH  - Guidelines as Topic
MH  - Internet/*standards
MH  - Medical Informatics/*standards
MH  - Radiology Information Systems/*standards
MH  - Telemedicine/*standards
EDAT- 2009/11/17 06:00
MHDA- 2010/04/15 06:00
CRDT- 2009/11/17 06:00
PHST- 2009/09/04 00:00 [received]
PHST- 2009/09/07 00:00 [accepted]
PHST- 2009/11/17 06:00 [entrez]
PHST- 2009/11/17 06:00 [pubmed]
PHST- 2010/04/15 06:00 [medline]
AID - S0720-048X(09)00582-8 [pii]
AID - 10.1016/j.ejrad.2009.10.018 [doi]
PST - ppublish
SO  - Eur J Radiol. 2010 Jan;73(1):31-5. doi: 10.1016/j.ejrad.2009.10.018. Epub 2009
      Nov 13.


PMID- 19913085
OWN - NLM
STAT- MEDLINE
DCOM- 20100128
LR  - 20151119
IS  - 1873-1899 (Electronic)
IS  - 0734-9750 (Linking)
VI  - 28
IP  - 1
DP  - 2010 Jan-Feb
TI  - Genetically modified and organic crops in developing countries: a review of
      options for food security.
PG  - 160-8
LID - 10.1016/j.biotechadv.2009.11.003 [doi]
AB  - Since two decades ago, when the first GM crops were introduced, there have
      increasingly been hot debates on the applications of gene manipulation.
      Currently, the development of GM crop varieties has raised a wide range of new
      legal, ethical and economic questions in agriculture. There is a growing body of 
      literature reflecting the socio-economic and environmental impacts of GM crops
      which aims to criticize their value for farming systems. While organic crops are 
      promoted as environmentally-friendly products in developed countries, they have
      provoked great controversy in developing countries facing food security and a low
      agricultural productivity. Discussion has been especially vigorous when organic
      farming was introduced as an alternative method. There are in fact, a few
      tradeoffs in developing countries. On the one hand, farmers are encouraged to
      accept and implement GM crops because of their higher productivity, while on the 
      other hand, organic farming is encouraged because of socio-economic and
      environmental considerations. A crucial question facing such countries is
      therefore, whether GM crops can co-exist with organic farming. This paper aims to
      review the main considerations and tradeoffs.
FAU - Azadi, Hossein
AU  - Azadi H
AD  - Centre for Development Studies, Faculty of Spatial Sciences, University of
      Groningen, The Netherlands. hos.azadi@gmail.com
FAU - Ho, Peter
AU  - Ho P
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Biotechnol Adv
JT  - Biotechnology advances
JID - 8403708
SB  - IM
MH  - *Crops, Agricultural/economics/supply & distribution
MH  - *Developing Countries
MH  - Food Supply/*economics
MH  - *Food, Genetically Modified/economics/supply & distribution
MH  - *Food, Organic/economics/supply & distribution
MH  - Humans
MH  - *Plants, Genetically Modified
MH  - Socioeconomic Factors
RF  - 119
EDAT- 2009/11/17 06:00
MHDA- 2010/01/29 06:00
CRDT- 2009/11/17 06:00
PHST- 2009/09/29 00:00 [received]
PHST- 2009/11/03 00:00 [revised]
PHST- 2009/11/05 00:00 [accepted]
PHST- 2009/11/17 06:00 [entrez]
PHST- 2009/11/17 06:00 [pubmed]
PHST- 2010/01/29 06:00 [medline]
AID - S0734-9750(09)00187-6 [pii]
AID - 10.1016/j.biotechadv.2009.11.003 [doi]
PST - ppublish
SO  - Biotechnol Adv. 2010 Jan-Feb;28(1):160-8. doi: 10.1016/j.biotechadv.2009.11.003.


PMID- 19912495
OWN - NLM
STAT- MEDLINE
DCOM- 20100830
LR  - 20191210
IS  - 1743-6109 (Electronic)
IS  - 1743-6095 (Linking)
VI  - 7
IP  - 4 Pt 1
DP  - 2010 Apr
TI  - A large multicenter outcome study of female genital plastic surgery.
PG  - 1565-77
LID - 10.1111/j.1743-6109.2009.01573.x [doi]
AB  - INTRODUCTION: Female Genital Plastic Surgery, a relatively new entry in the field
      of Cosmetic and Plastic Surgery, has promised sexual enhancement and functional
      and cosmetic improvement for women. Are the vulvovaginal aesthetic procedures of 
      Labiaplasty, Vaginoplasty/Perineoplasty ("Vaginal Rejuvenation") and Clitoral
      Hood Reduction effective, and do they deliver on that promise? For what reason do
      women seek these procedures? What complications are evident, and what effects are
      noted regarding sexual function for women and their partners? Who should be
      performing these procedures, what training should they have, and what are the
      ethical considerations? AIM: This study was designed to produce objective,
      utilizable outcome data regarding FGPS. MAIN OUTCOME MEASURES: 1) Reasons for
      considering surgery from both patient's and physician's perspective; 2)
      Pre-operative sexual functioning per procedure; 3) Overall patient satisfaction
      per procedure; 4) Effect of procedure on patient's sexual enjoyment, per
      procedure; 5) Patient's perception of effect on her partner's sexual enjoyment,
      per procedure; 6) Complications. METHODS: This cross-sectional study, including
      258 women and encompassing 341 separate procedures, comes from a group of twelve 
      gynecologists, gynecologic urologists and plastic surgeons from ten centers in
      eight states nationwide. 104 labiaplasties, 24 clitoral hood reductions, 49
      combined labiaplasty/clitoral hood reductions, 47 vaginoplasties and/or
      perineoplasties, and 34 combined labiaplasty and/or reduction of the clitoral
      hood plus vaginoplasty/perineoplasty procedures were studied retrospectively,
      analyzing both patient's and physician's perception of surgical rationale,
      pre-operative sexual function and several outcome criteria. RESULTS: Combining
      the three groups, 91.6% of patients were satisfied with the results of their
      surgery after a 6-42 month follow-up. Significant subjective enhancement in
      sexual functioning for both women and their sexual partners was noted (p =
      0.0078), especially in patients undergoing vaginal tightening/perineal support
      procedures. Complications were acceptable and not of major consequence.
      CONCLUSIONS: While emphasizing that these female genital plastic procedures are
      not performed to correct "abnormalities," as there is a wide range of normality
      in the external and internal female genitalia, both parous and nulliparous, many 
      women chose to modify their vulvas and vaginas. From the results of this large
      study pooling data from a diverse group of experienced genital plastic surgeons, 
      outcome in both general and sexual satisfaction appear excellent.
FAU - Goodman, Michael P
AU  - Goodman MP
AD  - Caring For Women Wellness Center--Gynecology and Genital Plastic Surgery, Davis, 
      CA, USA. michaelgoodman250@gmail.com
FAU - Placik, Otto J
AU  - Placik OJ
FAU - Benson, Royal H 3rd
AU  - Benson RH 3rd
FAU - Miklos, John R
AU  - Miklos JR
FAU - Moore, Robert D
AU  - Moore RD
FAU - Jason, Robert A
AU  - Jason RA
FAU - Matlock, David L
AU  - Matlock DL
FAU - Simopoulos, Alex F
AU  - Simopoulos AF
FAU - Stern, Bernard H
AU  - Stern BH
FAU - Stanton, Ryan A
AU  - Stanton RA
FAU - Kolb, Susan E
AU  - Kolb SE
FAU - Gonzalez, Federico
AU  - Gonzalez F
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20091112
PL  - Netherlands
TA  - J Sex Med
JT  - The journal of sexual medicine
JID - 101230693
SB  - IM
MH  - Adult
MH  - Clitoris/surgery
MH  - Cross-Sectional Studies
MH  - Ethics, Medical
MH  - Female
MH  - Genitalia, Female/*surgery
MH  - Humans
MH  - Motivation
MH  - Outcome and Process Assessment, Health Care
MH  - Patient Satisfaction
MH  - Perineum/surgery
MH  - Postoperative Complications/*etiology/psychology
MH  - Sexual Behavior
MH  - Specialization
MH  - *Surgery, Plastic/ethics/psychology
MH  - Surveys and Questionnaires
MH  - Vagina/surgery
MH  - Vulva/surgery
EDAT- 2009/11/17 06:00
MHDA- 2010/08/31 06:00
CRDT- 2009/11/17 06:00
PHST- 2009/11/17 06:00 [entrez]
PHST- 2009/11/17 06:00 [pubmed]
PHST- 2010/08/31 06:00 [medline]
AID - S1743-6095(15)32984-2 [pii]
AID - 10.1111/j.1743-6109.2009.01573.x [doi]
PST - ppublish
SO  - J Sex Med. 2010 Apr;7(4 Pt 1):1565-77. doi: 10.1111/j.1743-6109.2009.01573.x.
      Epub 2009 Nov 12.


PMID- 19912294
OWN - NLM
STAT- MEDLINE
DCOM- 20100802
LR  - 20100203
IS  - 1365-2354 (Electronic)
IS  - 0961-5423 (Linking)
VI  - 19
IP  - 1
DP  - 2010 Jan 1
TI  - Alleviating existential distress of cancer patients: can relational ethics guide 
      clinicians?
PG  - 30-8
LID - 10.1111/j.1365-2354.2008.00969.x [doi]
AB  - Most people have a heightened awareness of death at the moment they receive a
      cancer diagnosis. Medical treatment attempts to demystify and manage death, yet
      surprisingly, care that alleviates existential distress is the least provided
      psychosocial care. A review of empirical research [quantitative and qualitative
      studies (n = 85) and seven literature reviews] was conducted to explore the
      experiences of clinicians (primarily nurses) working with cancer patients who
      experience existential distress. This paper summarizes clinicians' experiences
      with cancer patients who face the threat of mortality. Given that the majority of
      literature was found to be in nursing, emphasis in this paper tends to be on
      nurses' experiences. However, findings are suggested to have implications for
      other clinicians who deal with similar concerns. A lens of relational ethics was 
      inductively found to organize and highlight problems and gaps that originate from
      interpersonal concerns. This paper describes four themes requiring further
      research and education related to existential distress: engagement, embodiment,
      environment and mutual respect. Implications for oncology care are suggested at
      the micro-, meso- and macro-levels to encourage clinicians to ethically respond
      to patients' existential distress needs.
FAU - Leung, D
AU  - Leung D
AD  - Lawrence S. Bloomberg Faculty of Nursing, University of Toronto, Toronto, ON,
      Canada. doris.leung@utoronto.ca
FAU - Esplen, M J
AU  - Esplen MJ
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20091111
PL  - England
TA  - Eur J Cancer Care (Engl)
JT  - European journal of cancer care
JID - 9301979
MH  - Attitude of Health Personnel
MH  - Attitude to Death
MH  - Attitude to Health
MH  - Existentialism/*psychology
MH  - Health Services Needs and Demand
MH  - Humans
MH  - Neoplasms/*psychology
MH  - Nurse-Patient Relations/ethics
MH  - Qualitative Research
RF  - 116
EDAT- 2009/11/17 06:00
MHDA- 2010/08/03 06:00
CRDT- 2009/11/17 06:00
PHST- 2009/11/17 06:00 [entrez]
PHST- 2009/11/17 06:00 [pubmed]
PHST- 2010/08/03 06:00 [medline]
AID - ECC969 [pii]
AID - 10.1111/j.1365-2354.2008.00969.x [doi]
PST - ppublish
SO  - Eur J Cancer Care (Engl). 2010 Jan 1;19(1):30-8. doi:
      10.1111/j.1365-2354.2008.00969.x. Epub 2009 Nov 11.


PMID- 19912281
OWN - NLM
STAT- MEDLINE
DCOM- 20100819
LR  - 20151119
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 10
IP  - 2
DP  - 2010 Aug
TI  - Training needs assessment in research ethics evaluation among research ethics
      committee members in three African countries: Cameroon, Mali and Tanzania.
PG  - 88-98
LID - 10.1111/j.1471-8847.2009.00266.x [doi]
AB  - BACKGROUND: As actors with the key responsibility for the protection of human
      research participants, Research Ethics Committees (RECs) need to be competent and
      well-resourced in order to fulfil their roles. Despite recent programs designed
      to strengthen RECs in Africa, much more needs to be accomplished before these
      committees can function optimally. OBJECTIVE: To assess training needs for
      biomedical research ethics evaluation among targeted countries. METHODS: Members 
      of RECs operating in three targeted African countries were surveyed between
      August and November 2007. Before implementing the survey, ethical approvals were 
      obtained from RECs in Switzerland, Cameroon, Mali and Tanzania. Data were
      collected using a semi-structured questionnaire in English and in French.
      RESULTS: A total of 74 respondents participated in the study. The participation
      rate was 68%. Seventy one percent of respondents reported having received some
      training in research ethics evaluation. This training was given by national
      institutions (31%) and international institutions (69%). Researchers and REC
      members were ranked as the top target audiences to be trained. Of 32 topics, the 
      top five training priorities were: basic ethical principles, coverage of
      applicable laws and regulations, how to conduct ethics review, evaluating
      informed consent processes and the role of the REC. CONCLUSION: Although the
      majority of REC members in the targeted African countries had received training
      in ethics, they expressed a need for additional training. The results of this
      survey have been used to design a training program in research ethics evaluation 
      that meets this need.
FAU - Ateudjieu, Jerome
AU  - Ateudjieu J
AD  - Faculty of Medicine and Biomedical Sciences; University of Yaounde 1,
      Cameroon--Centre for the Study and Control of Communicable Diseases, Melen
      Street, Yaounde Centre, Cameroon. atdjerom@yahoo.fr
FAU - Williams, John
AU  - Williams J
FAU - Hirtle, Marie
AU  - Hirtle M
FAU - Baume, Cedric
AU  - Baume C
FAU - Ikingura, Joyce
AU  - Ikingura J
FAU - Niare, Alassane
AU  - Niare A
FAU - Sprumont, Dominique
AU  - Sprumont D
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091112
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
SB  - IM
MH  - Cameroon
MH  - *Committee Membership
MH  - Cross-Sectional Studies
MH  - Ethics Committees, Research/*standards/trends
MH  - Ethics, Research/*education
MH  - Evaluation Studies as Topic
MH  - Humans
MH  - Mali
MH  - *Needs Assessment
MH  - Research Personnel/education
MH  - Surveys and Questionnaires
MH  - Tanzania
EDAT- 2009/11/17 06:00
MHDA- 2010/08/20 06:00
CRDT- 2009/11/17 06:00
PHST- 2009/11/17 06:00 [entrez]
PHST- 2009/11/17 06:00 [pubmed]
PHST- 2010/08/20 06:00 [medline]
AID - DEWB266 [pii]
AID - 10.1111/j.1471-8847.2009.00266.x [doi]
PST - ppublish
SO  - Dev World Bioeth. 2010 Aug;10(2):88-98. doi: 10.1111/j.1471-8847.2009.00266.x.
      Epub 2009 Nov 12.


PMID- 19912280
OWN - NLM
STAT- MEDLINE
DCOM- 20110105
LR  - 20101110
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 10
IP  - 3
DP  - 2010 Dec
TI  - Fairness and equity in the provision of anti-retroviral therapy: some reflections
      from Lesotho.
PG  - 129-40
LID - 10.1111/j.1471-8847.2009.00267.x [doi]
AB  - The number of people in immediate need of anti-retroviral treatment (ART) in the 
      southern African region continues to significantly exceed the capacity of health 
      systems there to provide it. Approaches to this complex rationing dilemma have
      evolved in different directions. The ethical concepts of fairness and equity have
      been suggested as a basis to guide the development of approaches to select
      patients for ART. This article reports the results of a case study on patient
      selection at a rural ART clinic in Lesotho. The purpose of the study was to
      examine whether or not such concepts had relevance or operative value for a
      treatment team providing ART in rural Lesotho. The study found that while
      concepts of fairness and equity were relevant to the work of the treatment team, 
      patient selection practices did not necessarily reflect what these concepts
      entail. The idea of fairness as a structured, formalized selection process did
      not figure in the approach to ART provision at the site. A less formal,
      'first-come-first-served' approach was adopted. While there was knowledge among
      some team members that social, economic or geographic conditions inhibit
      individuals and groups from gaining access to ART and that this was inequitable, 
      it was felt that there was little they could do to try to mediate the impact of
      these conditions. The study's findings pose importance questions about the
      approach to ART programming in resource constrained settings. The findings also
      question the relevance of trying to achieve fairness and equity when the gap
      between need for care and capacity to provide it remains so large.
CI  - (c) 2009 Blackwell Publishing Ltd.
FAU - Armstrong, Russell
AU  - Armstrong R
AD  - russellarms@gmail.com
LA  - eng
PT  - Journal Article
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
RN  - 0 (Anti-Retroviral Agents)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Anti-Retroviral Agents/*therapeutic use
MH  - Child
MH  - Female
MH  - Health Care Rationing/*ethics
MH  - Health Services Needs and Demand
MH  - Humans
MH  - International Cooperation
MH  - Lesotho
MH  - Male
MH  - Middle Aged
MH  - Patient Selection/*ethics
MH  - Rural Population/statistics & numerical data
MH  - *Social Justice/ethics
MH  - Switzerland
MH  - Young Adult
EDAT- 2009/11/17 06:00
MHDA- 2011/01/06 06:00
CRDT- 2009/11/17 06:00
PHST- 2009/11/17 06:00 [entrez]
PHST- 2009/11/17 06:00 [pubmed]
PHST- 2011/01/06 06:00 [medline]
AID - DEWB267 [pii]
AID - 10.1111/j.1471-8847.2009.00267.x [doi]
PST - ppublish
SO  - Dev World Bioeth. 2010 Dec;10(3):129-40. doi: 10.1111/j.1471-8847.2009.00267.x.


PMID- 19912253
OWN - NLM
STAT- MEDLINE
DCOM- 20100125
LR  - 20211020
IS  - 1365-2249 (Electronic)
IS  - 0009-9104 (Linking)
VI  - 159
IP  - 1
DP  - 2010 Jan
TI  - Gene expression profiles for the human pancreas and purified islets in type 1
      diabetes: new findings at clinical onset and in long-standing diabetes.
PG  - 23-44
LID - 10.1111/j.1365-2249.2009.04053.x [doi]
AB  - Type 1 diabetes (T1D) is caused by the selective destruction of the
      insulin-producing beta cells of the pancreas by an autoimmune response. Due to
      ethical and practical difficulties, the features of the destructive process are
      known from a small number of observations, and transcriptomic data are remarkably
      missing. Here we report whole genome transcript analysis validated by
      quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and
      correlated with immunohistological observations for four T1D pancreases
      (collected 5 days, 9 months, 8 and 10 years after diagnosis) and for purified
      islets from two of them. Collectively, the expression profile of immune response 
      and inflammatory genes confirmed the current views on the immunopathogenesis of
      diabetes and showed similarities with other autoimmune diseases; for example, an 
      interferon signature was detected. The data also supported the concept that the
      autoimmune process is maintained and balanced partially by regeneration and
      regulatory pathway activation, e.g. non-classical class I human leucocyte antigen
      and leucocyte immunoglobulin-like receptor, subfamily B1 (LILRB1). Changes in
      gene expression in islets were confined mainly to endocrine and neural genes,
      some of which are T1D autoantigens. By contrast, these islets showed only a few
      overexpressed immune system genes, among which bioinformatic analysis pointed to 
      chemokine (C-C motif) receptor 5 (CCR5) and chemokine (CXC motif) receptor 4)
      (CXCR4) chemokine pathway activation. Remarkably, the expression of genes of
      innate immunity, complement, chemokines, immunoglobulin and regeneration genes
      was maintained or even increased in the long-standing cases. Transcriptomic data 
      favour the view that T1D is caused by a chronic inflammatory process with a
      strong participation of innate immunity that progresses in spite of the
      regulatory and regenerative mechanisms.
FAU - Planas, R
AU  - Planas R
AD  - Laboratory of Immunobiology for Research and Applications to Diagnosis (LIRAD),
      Research Institute Germans Trias i Pujol, Badalona, Spain.
FAU - Carrillo, J
AU  - Carrillo J
FAU - Sanchez, A
AU  - Sanchez A
FAU - de Villa, M C Ruiz
AU  - de Villa MC
FAU - Nunez, F
AU  - Nunez F
FAU - Verdaguer, J
AU  - Verdaguer J
FAU - James, R F L
AU  - James RF
FAU - Pujol-Borrell, R
AU  - Pujol-Borrell R
FAU - Vives-Pi, M
AU  - Vives-Pi M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091111
PL  - England
TA  - Clin Exp Immunol
JT  - Clinical and experimental immunology
JID - 0057202
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-E antigen)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Pancreatitis-Associated Proteins)
RN  - 0 (REG3A protein, human)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antigens, CD/analysis/genetics/metabolism
MH  - Antigens, Neoplasm/genetics/metabolism
MH  - Biomarkers, Tumor/genetics/metabolism
MH  - C-Reactive Protein/genetics/metabolism
MH  - Cell Count
MH  - Diabetes Mellitus, Type 1/immunology/*metabolism/*pathology
MH  - Down-Regulation/genetics
MH  - Female
MH  - Gene Expression/genetics
MH  - *Gene Expression Profiling
MH  - Glucagon-Secreting Cells/metabolism
MH  - HLA Antigens/genetics/metabolism
MH  - Histocompatibility Antigens Class I/genetics/metabolism
MH  - Humans
MH  - Immunity, Innate/genetics
MH  - Inflammation/genetics
MH  - Insulin-Secreting Cells/metabolism
MH  - Islets of Langerhans/*metabolism/pathology
MH  - Lectins, C-Type/genetics/metabolism
MH  - Leukocytes/metabolism
MH  - Male
MH  - Middle Aged
MH  - Pancreas/*metabolism/*pathology
MH  - Pancreatitis-Associated Proteins
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Up-Regulation/genetics
MH  - Young Adult
PMC - PMC2802692
EDAT- 2009/11/17 06:00
MHDA- 2010/01/26 06:00
CRDT- 2009/11/17 06:00
PHST- 2009/11/17 06:00 [entrez]
PHST- 2009/11/17 06:00 [pubmed]
PHST- 2010/01/26 06:00 [medline]
AID - CEI4053 [pii]
AID - 10.1111/j.1365-2249.2009.04053.x [doi]
PST - ppublish
SO  - Clin Exp Immunol. 2010 Jan;159(1):23-44. doi: 10.1111/j.1365-2249.2009.04053.x.
      Epub 2009 Nov 11.


PMID- 19912199
OWN - NLM
STAT- MEDLINE
DCOM- 20100322
LR  - 20100121
IS  - 1464-410X (Electronic)
IS  - 1464-4096 (Linking)
VI  - 105
IP  - 3
DP  - 2010 Feb
TI  - Application of mesenchymal stromal cells in urological diseases.
PG  - 309-12
LID - 10.1111/j.1464-410X.2009.09077.x [doi]
AB  - The application of stem cells and their use in tissue-engineering approaches is
      emerging in clinical therapeutic intervention strategies. The use of adult stem
      cells, either autologous or allogenic, does not raise ethical concerns, in
      contrast to embryonic stem cells. Mesenchymal stromal cells (MSCs) can be easily 
      obtained from bone marrow or from adipose tissue and further expanded in vitro.
      Due to their differentiation capacity, MSCs are very attractive for tissue
      engineering purposes. Furthermore, MSCs secrete a variety of mediators that have 
      beneficial effects on the regenerating tissue. In this review we give an insight 
      into stem cell hierarchy, define the properties of MSCs and summarize recent
      reports of their administration in urological diseases.
FAU - Montzka, Katrin
AU  - Montzka K
AD  - Department of Urology, RWTH University Aachen, Aachen, Germany.
      kmontzka@ukaachen.de
FAU - Heidenreich, Axel
AU  - Heidenreich A
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20091113
PL  - England
TA  - BJU Int
JT  - BJU international
JID - 100886721
SB  - IM
MH  - Adult
MH  - Humans
MH  - Mesenchymal Stem Cell Transplantation/*methods
MH  - Stromal Cells/*transplantation
MH  - Tissue Engineering/methods
MH  - Urologic Diseases/*therapy
RF  - 41
EDAT- 2009/11/17 06:00
MHDA- 2010/03/23 06:00
CRDT- 2009/11/17 06:00
PHST- 2009/11/17 06:00 [entrez]
PHST- 2009/11/17 06:00 [pubmed]
PHST- 2010/03/23 06:00 [medline]
AID - BJU9077 [pii]
AID - 10.1111/j.1464-410X.2009.09077.x [doi]
PST - ppublish
SO  - BJU Int. 2010 Feb;105(3):309-12. doi: 10.1111/j.1464-410X.2009.09077.x. Epub 2009
      Nov 13.


PMID- 19912184
OWN - NLM
STAT- MEDLINE
DCOM- 20100810
LR  - 20191210
IS  - 1464-410X (Electronic)
IS  - 1464-4096 (Linking)
VI  - 106
IP  - 2
DP  - 2010 Jul
TI  - Transfer of cysto-urethroscopy skills from a virtual-reality simulator to the
      operating room: a randomized controlled trial.
PG  - 226-31; discussion 231
LID - 10.1111/j.1464-410X.2009.09049.x [doi]
AB  - OBJECTIVE: To assess whether real-time cysto-urethroscopy (CUS) performance
      improves by simulator-based training (criterion or predictive validity),
      addressing the research question 'Does practical skills training on the URO
      Mentor (UM, Simbionix USA Corp., Cleveland, OH, USA) virtual-reality simulator
      improve the performance of flexible CUS in patients'. SUBJECTS AND METHODS:
      Participants (71 interns from Catharina Hospital Eindhoven, CHE, and 29 from
      University Medical Centre Groningen, UMCG) were randomized to carry out CUS in a 
      patient after training on the UM (UM-trained, 50) or without training on UM
      (control, 50). The assessment of real-time performance consisted of scoring on a 
      Global Rating Scale (GRS) by supervisors unaware of training status. Data were
      analysed using stepwise multiple linear regression. The effect size (ES)
      indication for correlations was used to interpret the magnitude of a standard
      regression coefficient (beta); an ES of 0.10, 0.30 and 0.50 were considered
      small, moderate and large, respectively. The study was approved by the Medical
      Review Ethics Committees of the participating hospitals. RESULTS: Overall, the
      group that received training performed significantly better than the controls (P 
      < or = 0.003, beta range 0.30-0.47). There was no effect of training for
      participants with a specific preference for a surgical speciality in two of five 
      GRS scores. Participants from CHE obtained higher GRS 3 scores than those from
      UMCG. Significantly more UMCG trainees indicated having had stress than those
      from CHE (P < 0.001). CONCLUSIONS: The results showed that interns who had
      trained on UM outperformed controls for a CUS procedure in a patient. Training
      for CUS on the UM is to be recommended for learning to respect tissue, procedural
      knowledge, flow of procedure and forward planning. Use of the UM to train interns
      with a specific interest in a surgical speciality in handling instruments, and
      time and motion, seems to be of limited value.
FAU - Schout, Barbara M A
AU  - Schout BM
AD  - Catharina Hospital Eindhoven, Eindhoven, the Netherlands. barbara.schout@cze.nl
FAU - Ananias, Hildo J K
AU  - Ananias HJ
FAU - Bemelmans, Bart L H
AU  - Bemelmans BL
FAU - d'Ancona, Frank C H
AU  - d'Ancona FC
FAU - Muijtjens, Arno M M
AU  - Muijtjens AM
FAU - Dolmans, Valerie E M G
AU  - Dolmans VE
FAU - Scherpbier, Albert J J A
AU  - Scherpbier AJ
FAU - Hendrikx, Ad J M
AU  - Hendrikx AJ
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Validation Study
DEP - 20091112
PL  - England
TA  - BJU Int
JT  - BJU international
JID - 100886721
SB  - IM
MH  - Adult
MH  - Clinical Competence/*standards
MH  - Computer Simulation
MH  - Computer-Assisted Instruction/*methods/standards
MH  - Cystoscopy/*methods
MH  - Education, Medical, Continuing/*methods
MH  - Educational Measurement
MH  - Female
MH  - Humans
MH  - Male
MH  - Medical Staff, Hospital/*education
MH  - Single-Blind Method
MH  - Urologic Surgical Procedures/*education
MH  - Young Adult
EDAT- 2009/11/17 06:00
MHDA- 2010/08/11 06:00
CRDT- 2009/11/17 06:00
PHST- 2009/11/17 06:00 [entrez]
PHST- 2009/11/17 06:00 [pubmed]
PHST- 2010/08/11 06:00 [medline]
AID - BJU9049 [pii]
AID - 10.1111/j.1464-410X.2009.09049.x [doi]
PST - ppublish
SO  - BJU Int. 2010 Jul;106(2):226-31; discussion 231. doi:
      10.1111/j.1464-410X.2009.09049.x. Epub 2009 Nov 12.


PMID- 19912182
OWN - NLM
STAT- MEDLINE
DCOM- 20100816
LR  - 20220410
IS  - 1464-410X (Electronic)
IS  - 1464-4096 (Linking)
VI  - 106
IP  - 1
DP  - 2010 Jul
TI  - Two routes of transobturator tape procedures in stress urinary incontinence: a
      meta-analysis with direct and indirect comparison of randomized trials.
PG  - 68-76
LID - 10.1111/j.1464-410X.2009.09051.x [doi]
AB  - STUDY TYPE: Therapy (meta-analysis) Level of Evidence 1a. OBJECTIVES: To assess
      the effectiveness and complications of transobturator tape (inside-out and
      outside-in, TOT) by means of a systematic review of direct and indirect
      randomized controlled trials (RCTs). METHOD: MEDLINE, EMBASE, CINAHL, LILIACS (up
      to December 2008), CENTRAL (The Cochrane Library, Issue 1, 2009), MetaRegister of
      Controlled Trials, The National Library for Health, the National Research
      Register and Google Scholar were searched using various relevant search terms.
      The citation lists of review articles and included trials were searched and
      contact with the Correspondence of each included trials was attempted. RCTs which
      compared the effectiveness of synthetic transobturator (inside-out tape TVTO, or 
      outside-in TOT) with TVT by the retropubic route (Gynecare, Ethicon, Inc., or
      similar tape by a different company) or with each other for the treatment of
      stress urinary incontinence (SUI), and in all languages, were included. Two
      reviewers extracted data on participants' characteristics, study quality,
      intervention, cure and adverse effects independently. The data were analysed
      using Review Manager 5 software. RESULTS: There were 12 RCTs that compared TOT
      with TVT, and 15 that compared TVTO vs TVT for treating SUI. There were four
      direct comparison RCTs of TVTO vs TOT. When compared at 1-44 months, the
      subjective (odds ratio 1.16; 95% confidence interval 0.83-1.6) and objective
      (0.94; 0.66-1.32) cure of TOT was similar to TVT. For TVTO, the subjective (1.06,
      0.85-1.33) and objective cure (1.03, 0.77-1.39) was also similar to TVT. Adverse 
      events such as bladder injuries (TOT, odds ratio 0.11, 0.05-0.25; TVTO, 0.15,
      0.06-0.35) and haematomas (0.06, 0.01-0.30) were less in the TOT than TVT.
      Voiding difficulties (TOT, odds ratio 0.61, 0.35-1.07); TVTO, 0.81, 0.48-1.31)
      were slightly lower in TOT but this was not statistically significant.
      Groin/thigh pain (TVTO, odds ratio 8.05, 3.78-17.16) and vaginal injuries (TOT,
      5.82, 1.85-18.3; TVTO, 1.69, 0.73-3.91) were more common in the transobturator
      tapes. Mesh erosion in TVTO (0.77, 0.22-2.72) and TOT (1.11, 0.54-2.28) was
      similar to TVT. The effectiveness data over 6 months available from four direct
      comparison studies of TVTO vs TOT suggested equivalent results for objective cure
      (1.06, 0.65-1.73) and subjective cure (1.37, 0.93-2.00). When compared
      indirectly, TVTO has similar subjective (1.23, 0.83-1.82) and objective cure
      (0.97, 0.62-1.52) to TOT. On indirect comparison, the de novo risk of urgency was
      similar in the two groups but voiding difficulties seemed to be less in the
      inside-out group. CONCLUSION: The evidence for the equivalent effectiveness of
      TOT and TVTO when compared with each other is established over the short-term.
      Bladder injuries and voiding difficulties seem to be less with inside-out tapes
      on indirect comparison. An adequate long-term follow-up of the RCTs is desirable 
      to establish the long-term continued effectiveness of transobturator tapes.
FAU - Latthe, Pallavi M
AU  - Latthe PM
AD  - Department of Obstetrics and Gynaecology, Birmingham Women's Hospital,
      Birmingham, UK. pallavi.latthe@bwhct.nhs.uk
FAU - Singh, Pinki
AU  - Singh P
FAU - Foon, Richard
AU  - Foon R
FAU - Toozs-Hobson, Philip
AU  - Toozs-Hobson P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20091112
PL  - England
TA  - BJU Int
JT  - BJU international
JID - 100886721
SB  - IM
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Prospective Studies
MH  - Randomized Controlled Trials as Topic
MH  - *Suburethral Slings
MH  - Treatment Outcome
MH  - Urinary Incontinence, Stress/*surgery
MH  - Urologic Surgical Procedures/adverse effects/*methods
RF  - 58
EDAT- 2009/11/17 06:00
MHDA- 2010/08/17 06:00
CRDT- 2009/11/17 06:00
PHST- 2009/11/17 06:00 [entrez]
PHST- 2009/11/17 06:00 [pubmed]
PHST- 2010/08/17 06:00 [medline]
AID - BJU9051 [pii]
AID - 10.1111/j.1464-410X.2009.09051.x [doi]
PST - ppublish
SO  - BJU Int. 2010 Jul;106(1):68-76. doi: 10.1111/j.1464-410X.2009.09051.x. Epub 2009 
      Nov 12.


PMID- 19910522
OWN - NLM
STAT- MEDLINE
DCOM- 20100429
LR  - 20100212
IS  - 1552-5732 (Electronic)
IS  - 0890-3344 (Linking)
VI  - 26
IP  - 1
DP  - 2010 Feb
TI  - Principles of health care ethics and the WHO/UNICEF 10 steps to successful
      breastfeeding.
PG  - 11-4
LID - 10.1177/0890334409341562 [doi]
FAU - Gillis, Marin
AU  - Gillis M
AD  - University of Nevada School of Medicine, Reno, NV 89123, USA.
FAU - Sigman-Grant, Madeleine J
AU  - Sigman-Grant MJ
LA  - eng
PT  - Journal Article
DEP - 20091112
PL  - United States
TA  - J Hum Lact
JT  - Journal of human lactation : official journal of International Lactation
      Consultant Association
JID - 8709498
MH  - Breast Feeding/*psychology
MH  - *Ethics, Nursing
MH  - Female
MH  - Humans
MH  - *Informed Consent
MH  - Mothers/*psychology
MH  - Patient Satisfaction
MH  - *Personal Autonomy
MH  - Social Justice
MH  - United Nations
MH  - World Health Organization
EDAT- 2009/11/17 06:00
MHDA- 2010/04/30 06:00
CRDT- 2009/11/14 06:00
PHST- 2009/11/14 06:00 [entrez]
PHST- 2009/11/17 06:00 [pubmed]
PHST- 2010/04/30 06:00 [medline]
AID - 0890334409341562 [pii]
AID - 10.1177/0890334409341562 [doi]
PST - ppublish
SO  - J Hum Lact. 2010 Feb;26(1):11-4. doi: 10.1177/0890334409341562. Epub 2009 Nov 12.


PMID- 19910083
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20100201
IS  - 1532-2793 (Electronic)
IS  - 0260-6917 (Linking)
VI  - 30
IP  - 2
DP  - 2010 Feb
TI  - Understanding student nurse attrition: learning from the literature.
PG  - 202-7
LID - 10.1016/j.nedt.2009.07.014 [doi]
AB  - Student attrition in nursing causes concern, but is not a new phenomenon.
      Challenges in defining and understanding attrition, changes in the commissioning 
      of nurse education and developments within the United Kingdom National Health
      Service (UKNHS) and the profession contribute more generally to making this a
      complex topic for managers and for research. In this paper we discuss findings
      from an integrative review of the UK literature and discuss three levels of
      possible contributory factors identified from the literature (micro/individual;
      meso/institutional; and macro/political and professional). In conclusion, we
      argue that a concern with attrition is legitimate and that strategies should be
      put in place to respond to each level of contributory factors. Factors
      contributing to attrition are complex and interact. We argue that some degree of 
      attrition is inevitable if we are to maintain standards within the profession.
      There is, therefore, an ethical and professional imperative for attrition in some
      circumstances. We suggest that Tinto's model relating to social integration might
      inform further research.
CI  - Copyright 2009 Elsevier Ltd. All rights reserved.
FAU - Urwin, Sharon
AU  - Urwin S
AD  - Faculty of Health and Social Care Sciences, Kingston University and St. George's 
      University of London, Kingston Hill, Kingston upon Thames KT2 7LB, United
      Kingdom.
FAU - Stanley, Robert
AU  - Stanley R
FAU - Jones, Malcolm
AU  - Jones M
FAU - Gallagher, Ann
AU  - Gallagher A
FAU - Wainwright, Paul
AU  - Wainwright P
FAU - Perkins, Andrew
AU  - Perkins A
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20091112
PL  - Scotland
TA  - Nurse Educ Today
JT  - Nurse education today
JID - 8511379
MH  - Adaptation, Psychological
MH  - Career Choice
MH  - Decision Making
MH  - *Education, Nursing
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Interpersonal Relations
MH  - *Learning
MH  - Models, Educational
MH  - *Personnel Turnover
MH  - *Students, Nursing
RF  - 88
EDAT- 2009/11/17 06:00
MHDA- 2011/01/07 06:00
CRDT- 2009/11/14 06:00
PHST- 2008/03/18 00:00 [received]
PHST- 2009/07/08 00:00 [revised]
PHST- 2009/07/26 00:00 [accepted]
PHST- 2009/11/14 06:00 [entrez]
PHST- 2009/11/17 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
AID - S0260-6917(09)00147-6 [pii]
AID - 10.1016/j.nedt.2009.07.014 [doi]
PST - ppublish
SO  - Nurse Educ Today. 2010 Feb;30(2):202-7. doi: 10.1016/j.nedt.2009.07.014. Epub
      2009 Nov 12.


PMID- 19906487
OWN - NLM
STAT- MEDLINE
DCOM- 20100430
LR  - 20210112
IS  - 1872-6623 (Electronic)
IS  - 0304-3959 (Linking)
VI  - 148
IP  - 3
DP  - 2010 Mar
TI  - Ethical issues in opioid prescribing for chronic pain.
PG  - 365-367
LID - 10.1016/j.pain.2009.10.020 [doi]
FAU - Ballantyne, Jane C
AU  - Ballantyne JC
AD  - Penn Pain Medicine Center, Department of Anesthesiology and Critical Care,
      Tuttleman Building, 1840 South Street, Philadelphia, PA 19146, USA Department of 
      Anesthesiology and Critical Care, University of Pennsylvania Health System, 3400 
      Spruce Street, 6 Dulles Building, Philadelphia, PA 19104, USA.
FAU - Fleisher, Lee A
AU  - Fleisher LA
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20091110
PL  - United States
TA  - Pain
JT  - Pain
JID - 7508686
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Prescription Drugs)
SB  - IM
CIN - AMA J Ethics. 2015 Jun;17(6):521-9. PMID: 26075979
MH  - Analgesics, Opioid/*therapeutic use
MH  - Chronic Disease
MH  - *Ethics, Medical
MH  - Humans
MH  - Pain/*drug therapy
MH  - Prescription Drugs/*therapeutic use
RF  - 33
EDAT- 2009/11/13 06:00
MHDA- 2010/05/01 06:00
CRDT- 2009/11/13 06:00
PHST- 2009/09/29 00:00 [received]
PHST- 2009/10/21 00:00 [revised]
PHST- 2009/10/23 00:00 [accepted]
PHST- 2009/11/13 06:00 [entrez]
PHST- 2009/11/13 06:00 [pubmed]
PHST- 2010/05/01 06:00 [medline]
AID - 00006396-201003000-00006 [pii]
AID - 10.1016/j.pain.2009.10.020 [doi]
PST - ppublish
SO  - Pain. 2010 Mar;148(3):365-367. doi: 10.1016/j.pain.2009.10.020. Epub 2009 Nov 10.


PMID- 19906213
OWN - NLM
STAT- MEDLINE
DCOM- 20100804
LR  - 20211020
IS  - 1369-7625 (Electronic)
IS  - 1369-6513 (Linking)
VI  - 13
IP  - 1
DP  - 2010 Mar
TI  - An ethical justification for the Chronic Care Model (CCM).
PG  - 55-64
LID - 10.1111/j.1369-7625.2009.00581.x [doi]
AB  - BACKGROUND: Chronic diseases are major causes of morbidity and mortality in
      developed countries. Their effects can be mitigated by high quality
      evidence-based care, but this is not the norm in most systems. The Chronic Care
      Model (CCM) is an evidence-based policy response to this practice gap, which uses
      multiple strategies to promote the quality of chronic care. OBJECTIVE: To review 
      CCM with an ethical lens. METHODS: We reviewed the published empirical and
      non-empirical articles of CCM to analyse the ethical underpinnings of this model.
      RESULTS AND CONCLUSIONS: We argue that its principal ethical value lies in the
      institutional cooperation it builds between the stakeholders involved in health
      care services. First, we briefly describe CCM and argue that the pathways through
      which it aims to improve patients' health outcomes are not made explicit. Second,
      we argue that the potential of CCM to be more beneficent, compared with
      traditional health care systems, depends on its capacity to promote mutual trust 
      between health care providers and patients. There is no evidence to date that the
      implementation of CCM enhances mutual trust between health care professionals and
      patients. Third, we argue that CCM seeks to enhance human agency, allowing
      increased expression of individual autonomy and increased respect for individuals
      thereby expanding human freedom and avoiding social discrimination. However, we
      review the communication patterns that characterize the model of doctor-patient
      relationship promoted by this model and argue that these communication patterns
      raise ethical concerns that may prevent the model from reaching its expected
      outcomes.
FAU - Oprea, Liviu
AU  - Oprea L
AD  - Discipline of Public Health, The University of Adelaide, Adelaide, Australia.
      liviu.oprea@adelaide.edu.au
FAU - Braunack-Mayer, Annette
AU  - Braunack-Mayer A
FAU - Rogers, Wendy A
AU  - Rogers WA
FAU - Stocks, Nigel
AU  - Stocks N
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20091110
PL  - England
TA  - Health Expect
JT  - Health expectations : an international journal of public participation in health 
      care and health policy
JID - 9815926
SB  - IM
MH  - Chronic Disease/*therapy
MH  - Communication
MH  - Evidence-Based Medicine/*ethics
MH  - *Health Policy
MH  - Humans
MH  - *Models, Theoretical
MH  - Patient Participation
MH  - Physician-Patient Relations
MH  - Social Justice
MH  - Trust
RF  - 58
PMC - PMC5060517
EDAT- 2009/11/13 06:00
MHDA- 2010/08/05 06:00
CRDT- 2009/11/13 06:00
PHST- 2009/11/13 06:00 [entrez]
PHST- 2009/11/13 06:00 [pubmed]
PHST- 2010/08/05 06:00 [medline]
AID - HEX581 [pii]
AID - 10.1111/j.1369-7625.2009.00581.x [doi]
PST - ppublish
SO  - Health Expect. 2010 Mar;13(1):55-64. doi: 10.1111/j.1369-7625.2009.00581.x. Epub 
      2009 Nov 10.


PMID- 19903509
OWN - NLM
STAT- MEDLINE
DCOM- 20100226
LR  - 20181201
IS  - 1879-3185 (Electronic)
IS  - 0300-483X (Linking)
VI  - 267
IP  - 1-3
DP  - 2010 Jan 12
TI  - Relativism, regulation and the dangers of indifferent science: the Sir Roy
      Cameron lecture of the Royal College of Pathologists.
PG  - 7-13
LID - 10.1016/j.tox.2009.11.005 [doi]
AB  - The evaluation of data obtained from scientific investigations is not easy and
      the process often seems counterintuitive to the uninformed. Some commentators
      hold the conviction that ideological motives colour all deliberations-this makes 
      it easy to suggest that in any scientific debate an opponent's reason for holding
      a particular viewpoint or belief depends on his or her motives, rather than their
      knowledge base. This position may be useful in providing the grounds on which to 
      mount a polemic against any perceived threat (drugs in modern medicine,
      pesticides in intensive agriculture or genetically modified organisms). However, 
      its existence is not a reason to ignore the fact that the data obtained by use of
      the scientific method may be of a different kind from that which depends on
      opinions, honed by prejudices. Here I use prejudice to mean a bias that may be
      favourable or unfavourable to a particular viewpoint, rather than to a willful
      disregard of fact or an unreasoning predilection to arrive at a particular
      answer--the Precautionary Principle is a good example of only considering results
      that fit a preconceived viewpoint. The conviction that opinions cannot be based
      on independent thought has led to a disregard of professionalism and the
      development of the view that who pays you determines your opinion--not your
      science. This is relativism, which embodies the assertion that knowledge is
      relative and that ethical truths depend on the individuals and groups holding
      them-there are no absolutes. This compounds the problems of regulatory toxicology
      which is always beset by unavoidable uncertainties and suffers from being based
      on the use of the results of testing procedures many decades old which have
      themselves failed to incorporate new knowledge about the processes we investigate
      (see Hartung, 2009). A more vigorous assertion of the particular values of the
      scientific viewpoint and a willingness to incorporate new knowledge into
      regulatory decision making is necessary.
CI  - 2009 Elsevier Ireland Ltd. All rights reserved.
FAU - Berry, Colin L
AU  - Berry CL
AD  - Queen Mary Westfield College London, Pathology 1, College Gardens, Dulwich,
      London SE217BE, United Kingdom. berry@dulwich98.freeserve.co.uk
LA  - eng
PT  - Lecture
DEP - 20091110
PL  - Ireland
TA  - Toxicology
JT  - Toxicology
JID - 0361055
SB  - IM
MH  - Data Collection
MH  - Epidemiologic Factors
MH  - *Ethical Relativism
MH  - Pathology
MH  - Research Design
MH  - Science/legislation & jurisprudence/*methods
MH  - Societies, Medical
MH  - Toxicology
EDAT- 2009/11/12 06:00
MHDA- 2010/02/27 06:00
CRDT- 2009/11/12 06:00
PHST- 2009/04/14 00:00 [received]
PHST- 2009/10/09 00:00 [revised]
PHST- 2009/11/03 00:00 [accepted]
PHST- 2009/11/12 06:00 [entrez]
PHST- 2009/11/12 06:00 [pubmed]
PHST- 2010/02/27 06:00 [medline]
AID - S0300-483X(09)00581-2 [pii]
AID - 10.1016/j.tox.2009.11.005 [doi]
PST - ppublish
SO  - Toxicology. 2010 Jan 12;267(1-3):7-13. doi: 10.1016/j.tox.2009.11.005. Epub 2009 
      Nov 10.


PMID- 19900169
OWN - NLM
STAT- MEDLINE
DCOM- 20100312
LR  - 20101201
IS  - 1600-0684 (Electronic)
IS  - 0047-2565 (Linking)
VI  - 39
IP  - 1
DP  - 2010 Feb
TI  - Chimpanzees in hepatitis C virus research: 1998-2007.
PG  - 9-23
LID - 10.1111/j.1600-0684.2009.00390.x [doi]
AB  - BACKGROUND: Chimpanzees have been widely used in hepatitis C virus (HCV)
      research, but their endangered status and high financial and ethical costs have
      prompted a closer review. METHODS: One hundred and nine articles published in
      1998-2007 were analyzed for the number of chimpanzees involved, experimental
      procedures, objectives and other relevant issues. RESULTS: The articles described
      the use of 852 chimpanzees, but accounting for likely multiple uses, the number
      of individual chimpanzees involved here is estimated to be approximately 500.
      Most articles addressed immunology and inoculation studies. A significant portion
      of studies lasted for several months or years. Approximately one half of the
      individual chimpanzees were each used in 2-10 studies. CONCLUSIONS: Significant
      financial and scientific resources have been expended in these chimpanzee HCV
      studies. Discussion addresses troublesome questions presented by some of the
      reviewed articles, including statistical validity, repeatability, and biological 
      relevance of this model. These concerns merit attention as future approaches to
      HCV research and research priorities are considered.
FAU - Bettauer, R H
AU  - Bettauer RH
AD  - Bettauer BioMed Research, Mc Lean, VA, USA. raija.bettauer@verizon.net
LA  - eng
PT  - Journal Article
DEP - 20091109
PL  - Denmark
TA  - J Med Primatol
JT  - Journal of medical primatology
JID - 0320626
SB  - IM
CIN - J Med Primatol. 2010 Oct;39(5):361-2. PMID: 20727064
MH  - Animal Welfare/*ethics
MH  - Animals
MH  - Ape Diseases/*virology
MH  - Biomedical Research/ethics/methods
MH  - Hepacivirus/*growth & development
MH  - Hepatitis C/*veterinary/virology
MH  - *Pan troglodytes
MH  - Periodicals as Topic
EDAT- 2009/11/11 06:00
MHDA- 2010/03/13 06:00
CRDT- 2009/11/11 06:00
PHST- 2009/11/11 06:00 [entrez]
PHST- 2009/11/11 06:00 [pubmed]
PHST- 2010/03/13 06:00 [medline]
AID - JMP390 [pii]
AID - 10.1111/j.1600-0684.2009.00390.x [doi]
PST - ppublish
SO  - J Med Primatol. 2010 Feb;39(1):9-23. doi: 10.1111/j.1600-0684.2009.00390.x. Epub 
      2009 Nov 9.


PMID- 19899050
OWN - NLM
STAT- MEDLINE
DCOM- 20100503
LR  - 20100127
IS  - 1439-4421 (Electronic)
IS  - 0941-3790 (Linking)
VI  - 72
IP  - 1
DP  - 2010 Jan
TI  - [Equity in health? Health inequalities, ethics, and theories of distributive
      justice].
PG  - 48-53
LID - 10.1055/s-0029-1237743 [doi]
AB  - It is well-documented that the socio-economic status has an important influence
      on health. In all developed countries, health is closely correlated with income, 
      education, and type of employment, as well as with several other social
      determinants. While data on this socio-economic health gradient have been
      available for decades, the moral questions surrounding social health inequalities
      have only recently been addressed within the field of public health ethics. The
      present article offers a brief overview of relevant data on social health
      inequalities and on some explanatory models from epidemiology, social medicine
      and related disciplines. The main part explores three influential normative
      accounts addressing the issue of health inequalities. Finally, an agenda for
      future work in the field of public health ethics and health inequalities is
      sketched, with particular attention to the German context.
FAU - Buyx, A M
AU  - Buyx AM
AD  - Academic Scholar, The Harvard Program in Ethics and Health, Harvard Medical
      School, Boston, MA 02115, USA. alena_buyx@hms.harvard.edu
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Wie gleich kann Gesundheit sein? Ethische und gerechtigkeitstheoretische Aspekte 
      gesundheitlicher Ungleichheiten.
DEP - 20091106
PL  - Germany
TA  - Gesundheitswesen
JT  - Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes
      (Germany))
JID - 9204210
SB  - IM
MH  - *Bioethics
MH  - *Ethical Theory
MH  - Germany
MH  - Health Policy
MH  - Health Promotion/*ethics
MH  - Healthcare Disparities/*ethics
MH  - Humans
MH  - Moral Obligations
MH  - National Health Programs/*ethics
MH  - Primary Prevention/*ethics
MH  - Social Justice/*ethics
MH  - Social Values
MH  - *Socioeconomic Factors
EDAT- 2009/11/10 06:00
MHDA- 2010/05/04 06:00
CRDT- 2009/11/10 06:00
PHST- 2009/11/10 06:00 [entrez]
PHST- 2009/11/10 06:00 [pubmed]
PHST- 2010/05/04 06:00 [medline]
AID - 10.1055/s-0029-1237743 [doi]
PST - ppublish
SO  - Gesundheitswesen. 2010 Jan;72(1):48-53. doi: 10.1055/s-0029-1237743. Epub 2009
      Nov 6.


PMID- 19897856
OWN - NLM
STAT- MEDLINE
DCOM- 20100308
LR  - 20091217
IS  - 1460-2350 (Electronic)
IS  - 0268-1161 (Linking)
VI  - 25
IP  - 1
DP  - 2010 Jan
TI  - Patenting human pluripotent cells: balancing commercial, academic and ethical
      interests.
PG  - 14-21
LID - 10.1093/humrep/dep369 [doi]
AB  - The article addresses the issue of the ethics of patenting in human embryonic
      stem (hES) cells. The current stance of the European Patent Office in citing
      moral objections to patents on hES cells and the monopolistic scope of the
      Wisconsin Research Alumni Fund/Geron patents granted by the United States Patent 
      and Trademark Office represent twin obstacles to achieving an ethical balance in 
      patent rights in this field. The particular issues and strategies around granting
      patents on hES cells can be better understood by placing them in the context of
      the biotechnology industry and its role in the global bioeconomy. Some possible
      avenues of redress are considered based on the potential to open up cell
      pluripotency as new terrain for intellectual property offered by new
      technological breakthroughs such as induced pluripotent cells. Any changes in
      patent law should be accompanied by increased collaboration through devices such 
      as patent pools.
FAU - Bahadur, G
AU  - Bahadur G
AD  - North Middlesex University Hospital Trust, Sterling Way, London, Greater London
      N18 1QX, UK. bahadur.g@gmail.com
FAU - Morrison, M
AU  - Morrison M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091107
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
SB  - IM
MH  - Biotechnology/ethics
MH  - Embryo Research/*ethics
MH  - *Embryonic Stem Cells
MH  - Humans
MH  - Patents as Topic/*ethics
MH  - *Pluripotent Stem Cells
EDAT- 2009/11/10 06:00
MHDA- 2010/03/10 06:00
CRDT- 2009/11/10 06:00
PHST- 2009/11/10 06:00 [entrez]
PHST- 2009/11/10 06:00 [pubmed]
PHST- 2010/03/10 06:00 [medline]
AID - dep369 [pii]
AID - 10.1093/humrep/dep369 [doi]
PST - ppublish
SO  - Hum Reprod. 2010 Jan;25(1):14-21. doi: 10.1093/humrep/dep369. Epub 2009 Nov 7.


PMID- 19897849
OWN - NLM
STAT- MEDLINE
DCOM- 20100701
LR  - 20220317
IS  - 1460-2369 (Electronic)
IS  - 1355-4786 (Linking)
VI  - 16
IP  - 3
DP  - 2010 May-Jun
TI  - Experimental uterus transplantation.
PG  - 329-45
LID - 10.1093/humupd/dmp049 [doi]
AB  - BACKGROUND: Uterus transplantation (UTx) is developed in animal models as a
      future method to treat uterine factor infertility. METHODS: All published studies
      in the area of UTx research were identified. Aspects relating to surgery,
      cold-ischemia/reperfusion, rejection, immunosuppression, pregnancy, ethics and
      institutional requirements were examined. RESULTS: Uterus retrieval surgery has
      been solved in animals, including primates. Studies on cold-ischemia/reperfusion 
      indicate an ischemic tolerance of >24 h. The transplantation procedure, with
      vascular anastomosis, has not been fully developed in animal models, indicated by
      frequent thrombosis formation. Pregnancies have only been reported in
      syngenic/auto-UTx animal models. Several ethical issues in relation to UTx, and
      requirements for a team that would be suitable to undertake human UTx, exist.
      CONCLUSION: Much research on UTx has been performed in appropriate animal models.
      Several aspects of the procedure have been optimized but some remain to be
      solved. It is predicted that the research will soon reach a stage that could
      merit introduction of human UTx as an experimental procedure.
FAU - Brannstrom, Mats
AU  - Brannstrom M
AD  - Department of Obstetrics & Gynecology, Sahlgrenska University Hospital,
      Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden.
      mats.brannstrom@obgyn.gu.se
FAU - Wranning, Caiza A
AU  - Wranning CA
FAU - Altchek, Albert
AU  - Altchek A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20091107
PL  - England
TA  - Hum Reprod Update
JT  - Human reproduction update
JID - 9507614
SB  - IM
MH  - Anastomosis, Surgical/methods
MH  - Animals
MH  - Bioethical Issues
MH  - Female
MH  - Graft Rejection/prevention & control
MH  - Gynecologic Surgical Procedures/adverse effects/trends
MH  - Humans
MH  - Immunosuppression Therapy/adverse effects/methods
MH  - Infertility, Female/*surgery
MH  - Pregnancy
MH  - Pregnancy Outcome
MH  - Reperfusion Injury/prevention & control
MH  - Therapies, Investigational/adverse effects/trends
MH  - Uterus/abnormalities/physiology/*transplantation
RF  - 176
EDAT- 2009/11/10 06:00
MHDA- 2010/07/02 06:00
CRDT- 2009/11/10 06:00
PHST- 2009/11/10 06:00 [entrez]
PHST- 2009/11/10 06:00 [pubmed]
PHST- 2010/07/02 06:00 [medline]
AID - dmp049 [pii]
AID - 10.1093/humupd/dmp049 [doi]
PST - ppublish
SO  - Hum Reprod Update. 2010 May-Jun;16(3):329-45. doi: 10.1093/humupd/dmp049. Epub
      2009 Nov 7.


PMID- 19897766
OWN - NLM
STAT- MEDLINE
DCOM- 20100520
LR  - 20151119
IS  - 1941-2444 (Electronic)
IS  - 0148-6071 (Linking)
VI  - 34
IP  - 1
DP  - 2010 Jan-Feb
TI  - Ethical issues in artificial nutrition and hydration: a review.
PG  - 79-88
LID - 10.1177/0148607109347209 [doi]
AB  - Healthcare professionals often face clinical and ethical challenges when charged 
      with making decisions related to provision or lack of provision of artificial
      nutrition and hydration. The intent of this review is to supply a framework of
      clinical practices, ethical principles, legal precedents, and professional
      guidelines that will impart information and can assist decision making regarding 
      artificial nutrition and hydration. Comprehensive understanding of the theory and
      practice of informed consent for competent adults, decisionally incompetent
      adults, and minors is necessary for making valid clinical judgments and for
      guiding patients and their families or surrogates in choosing options related to 
      initiating, withholding, or withdrawing artificial nutrition and hydration. The
      framework offered in this review can serve as a basis for evaluation of
      appropriateness of artificial nutrition and hydration in 3 common conditions in
      which decision making is particularly challenging: terminal illness, advanced
      dementia, and a persistent vegetative state. The framework facilitates guidance
      for institutional policy makers and individual nutrition support professionals
      dealing with situations in which personal values often create ethical dilemmas
      related to artificial nutrition and hydration and its utility.
FAU - Geppert, Cynthia M A
AU  - Geppert CM
AD  - New Mexico Veteran's Affairs Health Care System and University of New Mexico
      School of Medicine, 1501 San Pedro Dr SE, Albuquerque NM 87108, USA.
      ethicdoc@comcast.net
FAU - Andrews, Maria R
AU  - Andrews MR
FAU - Druyan, Mary Ellen
AU  - Druyan ME
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20091106
PL  - United States
TA  - JPEN J Parenter Enteral Nutr
JT  - JPEN. Journal of parenteral and enteral nutrition
JID - 7804134
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Dementia/therapy
MH  - Ethics, Medical
MH  - Fluid Therapy/*ethics
MH  - Humans
MH  - Infant
MH  - Informed Consent
MH  - Nutritional Support/*ethics
MH  - Palliative Care/*ethics
MH  - Persistent Vegetative State/therapy
MH  - Practice Guidelines as Topic
MH  - Practice Patterns, Physicians'
MH  - Terminally Ill
RF  - 91
EDAT- 2009/11/10 06:00
MHDA- 2010/05/21 06:00
CRDT- 2009/11/10 06:00
PHST- 2009/11/10 06:00 [entrez]
PHST- 2009/11/10 06:00 [pubmed]
PHST- 2010/05/21 06:00 [medline]
AID - 0148607109347209 [pii]
AID - 10.1177/0148607109347209 [doi]
PST - ppublish
SO  - JPEN J Parenter Enteral Nutr. 2010 Jan-Feb;34(1):79-88. doi:
      10.1177/0148607109347209. Epub 2009 Nov 6.


PMID- 19897462
OWN - NLM
STAT- MEDLINE
DCOM- 20100409
LR  - 20211028
IS  - 1468-201X (Electronic)
IS  - 1355-6037 (Linking)
VI  - 96
IP  - 4
DP  - 2010 Feb
TI  - Prevention of cardiovascular disease: why do we neglect the most potent
      intervention?
PG  - 261-2
LID - 10.1136/hrt.2009.186593 [doi]
AB  - Despite a large volume of evidence supporting its cardioprotective properties and
      its other numerous established health benefits, physical activity is not a
      serious prescription option for the primary prevention of cardiovascular disease.
      On the other hand, health services increasingly focus on pharmacological
      prevention without considering properly the long-term consequences of medication.
      Ethical and feasibility considerations suggest that evidence on the protective
      value of physical activity may need to be evaluated using criteria different from
      those applying to pharmacological trials. The collateral health benefits of
      physical activity prescription support its use as standard option in preventive
      health care.
FAU - Stamatakis, Emmanuel
AU  - Stamatakis E
AD  - Department of Epidemiology and Public Health, University College London, 1-19
      Torrington Place, London WC1E 6BT, UK. e.stamatakis@ucl.ac.uk
FAU - Weiler, Richard
AU  - Weiler R
LA  - eng
GR  - CDF-2010-03-30/DH_/Department of Health/United Kingdom
GR  - PDA/03/07/056/DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091105
PL  - England
TA  - Heart
JT  - Heart (British Cardiac Society)
JID - 9602087
SB  - IM
MH  - Cardiovascular Diseases/*prevention & control
MH  - Humans
MH  - *Motor Activity
PMC - PMC3854700
EDAT- 2009/11/10 06:00
MHDA- 2010/04/10 06:00
CRDT- 2009/11/10 06:00
PHST- 2009/11/10 06:00 [entrez]
PHST- 2009/11/10 06:00 [pubmed]
PHST- 2010/04/10 06:00 [medline]
AID - hrt.2009.186593 [pii]
AID - 10.1136/hrt.2009.186593 [doi]
PST - ppublish
SO  - Heart. 2010 Feb;96(4):261-2. doi: 10.1136/hrt.2009.186593. Epub 2009 Nov 5.


PMID- 19897055
OWN - NLM
STAT- MEDLINE
DCOM- 20100504
LR  - 20220409
IS  - 1559-2030 (Electronic)
IS  - 1551-7144 (Linking)
VI  - 31
IP  - 1
DP  - 2010 Jan
TI  - International collaboration between US and Thailand on a clinical trial of
      treatment for HIV-associated cryptococcal meningitis.
PG  - 34-43
LID - 10.1016/j.cct.2009.11.002 [doi]
AB  - BACKGROUND: International clinical trials can provide scientific and logistic
      benefits in spite of the many challenges. Determining whether a country,
      especially a developing country, is an appropriate location for the research
      should include in-country consultation and partnering to assess its social value 
      for the population; that treatments are relevant for the population under study; 
      and that the research infrastructure and ethical oversight are adequate.
      Collaboration increases the likelihood of study success and helps ensure that
      benefits accrue to recruited populations and their community. PURPOSE: This paper
      describes our experiences on a bi-national study and may provide guidance for
      those planning to engage in future collaborations. METHODS: A Thai and United
      States team collaborated to develop and implement a phase II clinical trial for
      HIV-associated cryptococcal meningitis to assess safety and tolerability of
      combination therapy vs. standard treatment. Clinical and cultural differences,
      regulatory hurdles and operational issues were addressed before and during the
      study to ensure a successful collaboration between the 2 groups. RESULTS: The
      international multicenter study allowed for more rapid enrollment, reduced costs 
      to complete the study, sharing of the benefits of research, greater
      generalizability of results and capacity building in Thailand; quality metrics in
      Thailand were equivalent to or better than those in the U.S. CONCLUSIONS:
      Conducting successful clinical trials internationally requires early and ongoing 
      collaboration to ensure the study meets sites' requirements and expectations,
      conforms to varying national regulations, adheres to data quality standards and
      is responsive to the health needs of studied populations.
CI  - Copyright (c) 2009 Elsevier Inc. All rights reserved.
FAU - Zimmer, L O
AU  - Zimmer LO
AD  - Duke University Medical Center, Durham, NC, USA. Louise.Zimmer@Duke.edu
FAU - Nolen, T L
AU  - Nolen TL
FAU - Pramanpol, S
AU  - Pramanpol S
FAU - Wallace, D
AU  - Wallace D
FAU - Walker, M E
AU  - Walker ME
FAU - Pappas, P
AU  - Pappas P
FAU - Chetchotisakd, P
AU  - Chetchotisakd P
LA  - eng
SI  - ClinicalTrials.gov/NCT00145249
GR  - N01 AI015441/AI/NIAID NIH HHS/United States
GR  - N01AI15440/AI/NIAID NIH HHS/United States
GR  - 5R01AI1070091/AI/NIAID NIH HHS/United States
PT  - Clinical Trial, Phase II
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
DEP - 20091106
PL  - United States
TA  - Contemp Clin Trials
JT  - Contemporary clinical trials
JID - 101242342
RN  - 0 (Antifungal Agents)
RN  - 7XU7A7DROE (Amphotericin B)
RN  - 8VZV102JFY (Fluconazole)
SB  - IM
MH  - AIDS-Related Opportunistic Infections/*drug therapy
MH  - Adult
MH  - Amphotericin B/*administration & dosage/toxicity
MH  - Antifungal Agents/*administration & dosage/toxicity
MH  - Dose-Response Relationship, Drug
MH  - Drug Therapy, Combination
MH  - Feasibility Studies
MH  - Fluconazole/*administration & dosage/toxicity
MH  - Humans
MH  - *International Cooperation
MH  - Meningitis, Cryptococcal/*drug therapy
MH  - Patient Selection
MH  - Research Design
MH  - Thailand
MH  - United States
PMC - PMC2861565
MID - NIHMS160612
EDAT- 2009/11/10 06:00
MHDA- 2010/05/05 06:00
CRDT- 2009/11/10 06:00
PHST- 2009/06/17 00:00 [received]
PHST- 2009/10/30 00:00 [revised]
PHST- 2009/11/03 00:00 [accepted]
PHST- 2009/11/10 06:00 [entrez]
PHST- 2009/11/10 06:00 [pubmed]
PHST- 2010/05/05 06:00 [medline]
AID - S1551-7144(09)00178-5 [pii]
AID - 10.1016/j.cct.2009.11.002 [doi]
PST - ppublish
SO  - Contemp Clin Trials. 2010 Jan;31(1):34-43. doi: 10.1016/j.cct.2009.11.002. Epub
      2009 Nov 6.


PMID- 19897054
OWN - NLM
STAT- MEDLINE
DCOM- 20100504
LR  - 20211028
IS  - 1559-2030 (Electronic)
IS  - 1551-7144 (Linking)
VI  - 31
IP  - 1
DP  - 2010 Jan
TI  - Evaluating the quality of information about alternatives to research
      participation in oncology consent forms.
PG  - 18-21
LID - 10.1016/j.cct.2009.11.001 [doi]
AB  - A careful consideration of the alternatives to research participation is an
      essential element of making an informed choice to enroll in a biomedical research
      study. While there is general agreement on the importance of informing
      prospective subjects about alternatives to research participation, little is
      known about how investigators communicate this information. The purpose of this
      study was to attempt to assess the quality of information about alternatives
      contained in informed consent documents in oncology randomized controlled trials.
      Our study indicates that there is room for improvement concerning the discussion 
      of alternatives to research participation in informed consent documents in
      oncology randomized controlled trials. Though most of the documents in our study 
      met the minimal disclosure standard found in the U.S. federal regulations, less
      than a third met the reasonable person standard, a widely accepted principle
      endorsed by the common law and various ethics guidelines and documents. There was
      a statistically significant difference between the alternative discussions in
      local and model forms (P<0.0014). The alternatives discussions in local informed 
      consent documents were more likely to receive higher scores than those in model
      consent documents, with an odds-ratio of 3.5 to 1.
CI  - Published by Elsevier Inc.
FAU - Resnik, David B
AU  - Resnik DB
AD  - National Institute of Environmental Health Sciences, National Institutes of
      Health, Research Triangle Park, NC 27709, United States. resnikd@niehs.nih.gov
FAU - Patrone, Daniel
AU  - Patrone D
FAU - Peddada, Shyamal
AU  - Peddada S
LA  - eng
GR  - ZIA ES102646-01/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091106
PL  - United States
TA  - Contemp Clin Trials
JT  - Contemporary clinical trials
JID - 101242342
SB  - IM
MH  - Consent Forms/ethics/legislation & jurisprudence
MH  - Decision Making/*ethics
MH  - *Ethics, Research
MH  - Humans
MH  - Informed Consent/*ethics/*legislation & jurisprudence
MH  - Neoplasms/*therapy
MH  - Patient Education as Topic/*ethics/*standards
MH  - Patient Selection/*ethics
MH  - Randomized Controlled Trials as Topic/*ethics/*standards
PMC - PMC2819206
MID - NIHMS171881
EDAT- 2009/11/10 06:00
MHDA- 2010/05/05 06:00
CRDT- 2009/11/10 06:00
PHST- 2009/08/18 00:00 [received]
PHST- 2009/10/28 00:00 [revised]
PHST- 2009/11/03 00:00 [accepted]
PHST- 2009/11/10 06:00 [entrez]
PHST- 2009/11/10 06:00 [pubmed]
PHST- 2010/05/05 06:00 [medline]
AID - S1551-7144(09)00177-3 [pii]
AID - 10.1016/j.cct.2009.11.001 [doi]
PST - ppublish
SO  - Contemp Clin Trials. 2010 Jan;31(1):18-21. doi: 10.1016/j.cct.2009.11.001. Epub
      2009 Nov 6.


PMID- 19896857
OWN - NLM
STAT- MEDLINE
DCOM- 20100429
LR  - 20100921
IS  - 1878-4119 (Electronic)
IS  - 1010-5182 (Linking)
VI  - 38
IP  - 1
DP  - 2010 Jan
TI  - Publication bias in oral and maxillofacial surgery journals: an observation on
      published controlled trials.
PG  - 4-10
LID - 10.1016/j.jcms.2009.10.005 [doi]
AB  - BACKGROUND: Publication bias (PB) diminishes the full distribution of research,
      distorts and discredits the scientific record, and thus compromises
      evidence-based practice. The objective of this study was to analyse published
      controlled trials with regard to PB in leading oral and maxillofacial surgery
      (OMS) journals. METHODS: All controlled trials published in the International
      Journal of Oral and Maxillofacial Surgery, Journal of Cranio-Maxillofacial
      Surgery, Journal of Oral and Maxillofacial Surgery, and British Journal of Oral
      and Maxillofacial Surgery in 2008 were analysed for a primary outcome, country of
      authors, sample size, gender of the first author, funding source and location of 
      the study. RESULTS: Of 952 published articles, 53 controlled trials (5.7%) were
      identified. The OMS journals preferentially published controlled trials with a
      positive outcome (77.4%) and from high-income countries (73.6%). Single-centred
      trials (86.8%) with low sample size (n<100; 69.8%) were published more
      frequently. The majority of the first authors were male (75.5%). Funding source
      disclosure was missing in most studies (73.6%) [corrected]. CONCLUSIONS: Our
      results suggest the possible existence of PB in the OMS literature. Hence, it
      should be borne in mind that the published articles may not be representative of 
      all scientific works, especially when systematic reviews and meta-analyses are
      conducted or read. In the meantime, journals should establish measures to
      eliminate PB to uphold scientific integrity. However, this study was an
      observation based on the published articles. An analysis of all submitted
      manuscripts would provide more accurate estimates of PB. Ethical considerations
      on PB are also discussed.
FAU - Pitak-Arnnop, Poramate
AU  - Pitak-Arnnop P
AD  - Department of Oral, Craniomaxillofacial and Facial Plastic Surgery, Faculty of
      Medicine, University Hospital of Leipzig, Leipzig, Germany.
      poramate.pitakarnnop@gmail.com <poramate.pitakarnnop@gmail.com>
FAU - Sader, Robert
AU  - Sader R
FAU - Rapidis, Alexander D
AU  - Rapidis AD
FAU - Dhanuthai, Kittipong
AU  - Dhanuthai K
FAU - Bauer, Ute
AU  - Bauer U
FAU - Herve, Chistian
AU  - Herve C
FAU - Hemprich, Alexander
AU  - Hemprich A
LA  - eng
PT  - Journal Article
DEP - 20091106
PL  - Scotland
TA  - J Craniomaxillofac Surg
JT  - Journal of cranio-maxillo-facial surgery : official publication of the European
      Association for Cranio-Maxillo-Facial Surgery
JID - 8704309
SB  - IM
EIN - J Craniomaxillofac Surg. 2010 Oct;38(7):541
MH  - Authorship
MH  - *Bibliometrics
MH  - *Controlled Clinical Trials as Topic
MH  - Humans
MH  - *Journalism, Dental
MH  - *Oral Surgical Procedures
MH  - Publication Bias/*statistics & numerical data
EDAT- 2009/11/10 06:00
MHDA- 2010/04/30 06:00
CRDT- 2009/11/10 06:00
PHST- 2009/03/30 00:00 [received]
PHST- 2009/09/13 00:00 [revised]
PHST- 2009/10/05 00:00 [accepted]
PHST- 2009/11/10 06:00 [entrez]
PHST- 2009/11/10 06:00 [pubmed]
PHST- 2010/04/30 06:00 [medline]
AID - S1010-5182(09)00169-3 [pii]
AID - 10.1016/j.jcms.2009.10.005 [doi]
PST - ppublish
SO  - J Craniomaxillofac Surg. 2010 Jan;38(1):4-10. doi: 10.1016/j.jcms.2009.10.005.
      Epub 2009 Nov 6.


PMID- 19896255
OWN - NLM
STAT- MEDLINE
DCOM- 20100309
LR  - 20211020
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 70
IP  - 3
DP  - 2010 Feb
TI  - Developing a longitudinal database of routinely recorded primary care
      consultations linked to service use and outcome data.
PG  - 473-478
LID - S0277-9536(09)00701-1 [pii]
LID - 10.1016/j.socscimed.2009.10.025 [doi]
AB  - The primary care consultation provides access to the majority of health care
      services and is central to obtaining diagnoses, treatment and ongoing management 
      of long-term conditions. This paper reports the findings of an interdisciplinary 
      feasibility study to explore the benefits and practical, technical and ethical
      challenges (and solutions) of creating a longitudinal database of recorded GP
      consultations in Tayside, Scotland which could be linked to existing routine data
      on intermediate and long-term health outcomes. After consultation we attempted to
      recruit and audio-record the consultations of all patients attending three
      general practices over a two week period. Background patient data, and patient
      and staff experiences of participation were also collected. Eventually, two
      practices participated with 77% of patients approached agreeing to participate.
      The findings suggest that the perceived integrity of the consultation was
      preserved. The overwhelming majority of patients believed that recording was
      worthwhile and did not feel it impacted on communication or the treatment they
      received; 93% indicated they would be willing to have subsequent consultations
      recorded and 81% would recommend participation to a friend. Staff had similar
      beliefs but raised concerns about potential increases in workload,
      confidentiality issues and ease of software use. We conclude that practice
      participation could be increased by providing safeguards on data use, financial
      reward, integrated recording software, and procedures to lessen the impact on
      workload. The resulting Scottish Clinical Interactions Project (SCIP) would
      provide the largest and most detailed longitudinal insight into real world
      medical consultations in the world, permitting the linking of consultation events
      and practices to subsequent outcomes and behaviours.
CI  - Crown Copyright 2009. Published by Elsevier Ltd. All rights reserved.
FAU - Williams, Brian
AU  - Williams B
AD  - Centre for Population Sciences & Education, Ninewells Hospital & Medical School, 
      University of Dundee, United Kingdom. Electronic address:
      b.y.williams@cpse.dundee.ac.uk.
FAU - Dowell, Jon
AU  - Dowell J
AD  - Centre for Population Sciences & Education, Ninewells Hospital & Medical School, 
      University of Dundee, United Kingdom.
FAU - Humphris, Gerry
AU  - Humphris G
AD  - Bute Medical School, University of St Andrews, United Kingdom.
FAU - Themessl-Huber, Markus
AU  - Themessl-Huber M
AD  - School of Nursing & Midwifery, University of Dundee, United Kingdom.
FAU - Rushmer, Rosemary
AU  - Rushmer R
AD  - Department of Management, University of St Andrews, United Kingdom.
FAU - Ricketts, Ian
AU  - Ricketts I
AD  - School of Computing, University of Dundee, United Kingdom.
FAU - Boyle, Paul
AU  - Boyle P
AD  - School of Geography & Geosciences, University of St Andrews, United Kingdom.
FAU - Sullivan, Frank
AU  - Sullivan F
AD  - Centre for Population Sciences & Education, Ninewells Hospital & Medical School, 
      University of Dundee, United Kingdom.
LA  - eng
GR  - NMAHP1/CSO_/Chief Scientist Office/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091104
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Attitude of Health Personnel
MH  - Attitude to Health
MH  - *Databases as Topic
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Outcome and Process Assessment, Health Care
MH  - Physician-Patient Relations
MH  - Pilot Projects
MH  - Primary Health Care/*methods
MH  - Scotland
MH  - Surveys and Questionnaires
MH  - *Tape Recording
EDAT- 2009/11/10 06:00
MHDA- 2010/03/10 06:00
CRDT- 2009/11/10 06:00
PHST- 2008/12/04 00:00 [received]
PHST- 2009/11/10 06:00 [entrez]
PHST- 2009/11/10 06:00 [pubmed]
PHST- 2010/03/10 06:00 [medline]
AID - S0277-9536(09)00701-1 [pii]
AID - 10.1016/j.socscimed.2009.10.025 [doi]
PST - ppublish
SO  - Soc Sci Med. 2010 Feb;70(3):473-478. doi: 10.1016/j.socscimed.2009.10.025. Epub
      2009 Nov 4.


PMID- 19896236
OWN - NLM
STAT- MEDLINE
DCOM- 20100423
LR  - 20100215
IS  - 1872-8332 (Electronic)
IS  - 0169-5002 (Linking)
VI  - 67
IP  - 3
DP  - 2010 Mar
TI  - Lung cancer in the pregnant woman: to treat or not to treat, that is the
      question.
PG  - 251-6
LID - 10.1016/j.lungcan.2009.10.006 [doi]
AB  - Lung cancer in pregnancy is a rare situation; however, it is increasingly
      reported in the past two decades. The association might be more encountered in
      the coming years due to the rising trends of cigarette smoking among young women 
      and tendency to delay pregnancy to later in life. We performed a literature
      search without any date or language restriction and identified 44 cases diagnosed
      and/or treated for lung cancer during the course of pregnancy. Patients had poor 
      post-partum outcome with less than one-forth alive at 1 year following delivery. 
      There was a high incidence of metastases to the products of conception reaching
      26%. Eight patients were treated with systemic therapies during the course of
      gestation with normal fetal outcome and no evidence of fetal or placental
      metastases. Counseling of these patients is very important. Apart from the
      clinical conflict they pose, some ethical aspects should be taken in
      consideration. The poor maternal prognosis should be discussed and the patient's 
      autonomy should be respected to decide whether she wants to keep the pregnancy or
      not.
FAU - Azim, Hatem A Jr
AU  - Azim HA Jr
AD  - Department of Medical Oncology, National Cancer Institute, Cairo University,
      Mohandeseen, Cairo, Egypt. hatemazim@cairocure.com
FAU - Peccatori, Fedro A
AU  - Peccatori FA
FAU - Pavlidis, Nicholas
AU  - Pavlidis N
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20091105
PL  - Ireland
TA  - Lung Cancer
JT  - Lung cancer (Amsterdam, Netherlands)
JID - 8800805
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - Fetus/pathology
MH  - Humans
MH  - Lung Neoplasms/diagnosis/pathology/*therapy
MH  - Magnetic Resonance Imaging
MH  - Neoplasm Metastasis
MH  - Placenta/pathology
MH  - Pregnancy
MH  - Pregnancy Complications, Neoplastic/diagnosis/pathology/*therapy
MH  - Prognosis
MH  - Young Adult
RF  - 65
EDAT- 2009/11/10 06:00
MHDA- 2010/04/24 06:00
CRDT- 2009/11/10 06:00
PHST- 2009/09/02 00:00 [received]
PHST- 2009/10/01 00:00 [revised]
PHST- 2009/10/03 00:00 [accepted]
PHST- 2009/11/10 06:00 [entrez]
PHST- 2009/11/10 06:00 [pubmed]
PHST- 2010/04/24 06:00 [medline]
AID - S0169-5002(09)00505-4 [pii]
AID - 10.1016/j.lungcan.2009.10.006 [doi]
PST - ppublish
SO  - Lung Cancer. 2010 Mar;67(3):251-6. doi: 10.1016/j.lungcan.2009.10.006. Epub 2009 
      Nov 5.


PMID- 19892821
OWN - NLM
STAT- MEDLINE
DCOM- 20100315
LR  - 20211020
IS  - 1745-1701 (Electronic)
IS  - 0586-7614 (Linking)
VI  - 36
IP  - 1
DP  - 2010 Jan
TI  - Political abuse of psychiatry--an historical overview.
PG  - 33-5
LID - 10.1093/schbul/sbp119 [doi]
AB  - The use of psychiatry for political purposes has been a major subject of debate
      within the world psychiatric community during the second half of the 20th
      century. The issue became prominent in the 1970s and 1980s due to the systematic 
      political abuse of psychiatry in the Soviet Union, where approximately one-third 
      of the political prisoners were locked up in psychiatric hospitals. The issue
      caused a major rift within the World Psychiatric Association, from which the
      Soviets were forced to withdraw in 1983. They returned conditionally in 1989.
      Political abuse of psychiatry took also place in other socialist countries and on
      a systematic scale in Romania, and during the first decade of the 21st century,
      it became clear that systematic political abuse of psychiatry is also happening
      in the People's Republic of China. The article discusses the historical
      background to these abuses and concludes that the issue had a major impact on the
      development of concepts regarding medical ethics and the professional
      responsibility of physicians.
FAU - van Voren, Robert
AU  - van Voren R
AD  - Global Initiative on Psychiatry, Postbus 1282, 1200 BG, Hilversum, The
      Netherlands. rvvoren@gip-global.org
LA  - eng
PT  - Historical Article
PT  - Journal Article
DEP - 20091105
PL  - United States
TA  - Schizophr Bull
JT  - Schizophrenia bulletin
JID - 0236760
SB  - IM
MH  - Commitment of Mentally Ill/*history
MH  - Dissent and Disputes/*history
MH  - Ethics, Medical/*history
MH  - History, 20th Century
MH  - Human Rights/*history
MH  - Humans
MH  - Moscow
MH  - Psychiatry/*history
MH  - Schizophrenia/*history
MH  - Socialism/*history
MH  - USSR
PMC - PMC2800147
EDAT- 2009/11/07 06:00
MHDA- 2010/03/17 06:00
CRDT- 2009/11/07 06:00
PHST- 2009/11/07 06:00 [entrez]
PHST- 2009/11/07 06:00 [pubmed]
PHST- 2010/03/17 06:00 [medline]
AID - sbp119 [pii]
AID - 10.1093/schbul/sbp119 [doi]
PST - ppublish
SO  - Schizophr Bull. 2010 Jan;36(1):33-5. doi: 10.1093/schbul/sbp119. Epub 2009 Nov 5.


PMID- 19890947
OWN - NLM
STAT- MEDLINE
DCOM- 20100513
LR  - 20100218
IS  - 1526-4998 (Electronic)
IS  - 1526-498X (Linking)
VI  - 66
IP  - 3
DP  - 2010 Mar
TI  - What can pest management learn from laboratory animal ethics?
PG  - 231-7
LID - 10.1002/ps.1870 [doi]
AB  - There remains a lack of a clear overarching policy framework for decision-making 
      in pest control programmes. In comparison, ethical principles have been
      extensively developed for scientific procedures, such as those underlying the
      UK's Animals (Scientific Procedures) Act 1986. This paper assesses the extent to 
      which the principles and methodology underlying the act and secondary guidance
      could be used to provide principles of rodent management. Useful principles
      include that any programme has a legitimate purpose; that methods are used only
      if the harms are outweighed by the benefits; that harms are minimised by
      refinement, replacement and reduction and that there is personal responsibility. 
      The usefulness and implications for pest control of each principle and the
      overall approach are discussed.
FAU - Yeates, James
AU  - Yeates J
AD  - Animal Behaviour and Welfare Group, Department of Clinical Veterinary Science,
      University of Bristol, UK. James.Yeates@bristol.ac.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - Pest Manag Sci
JT  - Pest management science
JID - 100898744
SB  - IM
MH  - Animal Welfare/*ethics
MH  - Animals
MH  - *Animals, Laboratory
MH  - Humans
MH  - Pest Control/*ethics/legislation & jurisprudence
MH  - Risk Assessment
EDAT- 2009/11/06 06:00
MHDA- 2010/05/14 06:00
CRDT- 2009/11/06 06:00
PHST- 2009/11/06 06:00 [entrez]
PHST- 2009/11/06 06:00 [pubmed]
PHST- 2010/05/14 06:00 [medline]
AID - 10.1002/ps.1870 [doi]
PST - ppublish
SO  - Pest Manag Sci. 2010 Mar;66(3):231-7. doi: 10.1002/ps.1870.


PMID- 19889472
OWN - NLM
STAT- MEDLINE
DCOM- 20100507
LR  - 20100217
IS  - 1872-6054 (Electronic)
IS  - 0168-8510 (Linking)
VI  - 94
IP  - 3
DP  - 2010 Mar
TI  - Development and dissemination of institutional practice guidelines on medical
      end-of-life decisions in Dutch health care institutions.
PG  - 230-8
LID - 10.1016/j.healthpol.2009.09.016 [doi]
AB  - OBJECTIVES: To describe how Dutch healthcare institutions develop and disseminate
      institutional practice guidelines on medical end-of-life decisions and policy
      statements on euthanasia and physician-assisted suicide (EAS) to relevant
      parties, and to describe supportiveness of EAS guidelines experienced by Dutch
      physicians. METHODS: Questionnaires to all Dutch health care institutions in
      2005. Questionnaire to sample of Dutch clinical specialists and nursing home
      physicians. RESULTS: In most health care institutions, physicians (79%), ethics
      committees (79%), board of directors (64%) and nurses (61%) were involved in the 
      development of guidelines. The Euthanasia Act and national guidelines were the
      most frequently reported sources for the development (73% and 71%, respectively).
      Not all institutions disseminated their written EAS policy statements and
      practice guidelines on medical end-of-life decisions to all relevant parties.
      Dutch physicians who reported the presence of a written guideline for EAS in
      their institution, felt supported by it in their decision-making after a
      patient's request for EAS. CONCLUSIONS: It is recommended that more health care
      institutions pay attention to the dissemination of their policy statements and
      practice guidelines to relevant parties. This will only lead to improvement in
      medical practice if this is accompanied by efforts to also stimulate the use of
      guidelines in practice.
FAU - Hesselink, Berniek A M
AU  - Hesselink BA
AD  - VU University Medical Center, EMGO Institute for Health and Care Research,
      Department of Public and Occupational Health, Van der Boechorststraat 7,
      Amsterdam, The Netherlands. berniek.hesselink@vumc.nl
FAU - Pasman, H Roeline W
AU  - Pasman HR
FAU - van der Wal, Gerrit
AU  - van der Wal G
FAU - van der Maas, Paul J
AU  - van der Maas PJ
FAU - van der Heide, Agnes
AU  - van der Heide A
FAU - Onwuteaka-Philipsen, Bregje D
AU  - Onwuteaka-Philipsen BD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091103
PL  - Ireland
TA  - Health Policy
JT  - Health policy (Amsterdam, Netherlands)
JID - 8409431
MH  - Euthanasia
MH  - Hospitals/standards
MH  - Humans
MH  - Information Dissemination/*methods
MH  - Netherlands
MH  - Nursing Homes/standards
MH  - Physicians
MH  - Policy Making
MH  - *Practice Guidelines as Topic
MH  - Quality of Health Care
MH  - Suicide, Assisted
MH  - Terminal Care/*standards
EDAT- 2009/11/06 06:00
MHDA- 2010/05/08 06:00
CRDT- 2009/11/06 06:00
PHST- 2009/03/31 00:00 [received]
PHST- 2009/09/18 00:00 [revised]
PHST- 2009/09/30 00:00 [accepted]
PHST- 2009/11/06 06:00 [entrez]
PHST- 2009/11/06 06:00 [pubmed]
PHST- 2010/05/08 06:00 [medline]
AID - S0168-8510(09)00259-0 [pii]
AID - 10.1016/j.healthpol.2009.09.016 [doi]
PST - ppublish
SO  - Health Policy. 2010 Mar;94(3):230-8. doi: 10.1016/j.healthpol.2009.09.016. Epub
      2009 Nov 3.


PMID- 19889184
OWN - NLM
STAT- MEDLINE
DCOM- 20100810
LR  - 20100506
IS  - 1540-8159 (Electronic)
IS  - 0147-8389 (Linking)
VI  - 33
IP  - 2
DP  - 2010 Feb
TI  - Ethics in electrophysiology: a complaint from palliative care.
PG  - 226-7
LID - 10.1111/j.1540-8159.2009.02597.x [doi]
FAU - Beauregard, Lou-Anne M
AU  - Beauregard LA
AD  - Heart Specialists of Central Jersey, 100 Craig Road, Manalapan, NJ 07726, USA.
      drbeauregard@gmail.com
LA  - eng
PT  - Journal Article
DEP - 20091102
PL  - United States
TA  - Pacing Clin Electrophysiol
JT  - Pacing and clinical electrophysiology : PACE
JID - 7803944
SB  - IM
MH  - Defibrillators, Implantable/*ethics
MH  - Electric Countershock/*ethics
MH  - Electrophysiology/*ethics
MH  - Humans
MH  - *Life Expectancy
MH  - Palliative Care/*ethics
EDAT- 2009/11/06 06:00
MHDA- 2010/08/11 06:00
CRDT- 2009/11/06 06:00
PHST- 2009/11/06 06:00 [entrez]
PHST- 2009/11/06 06:00 [pubmed]
PHST- 2010/08/11 06:00 [medline]
AID - PACE2597 [pii]
AID - 10.1111/j.1540-8159.2009.02597.x [doi]
PST - ppublish
SO  - Pacing Clin Electrophysiol. 2010 Feb;33(2):226-7. doi:
      10.1111/j.1540-8159.2009.02597.x. Epub 2009 Nov 2.


PMID- 19888595
OWN - NLM
STAT- MEDLINE
DCOM- 20100713
LR  - 20211020
IS  - 1432-1246 (Electronic)
IS  - 0340-0131 (Linking)
VI  - 83
IP  - 4
DP  - 2010 Apr
TI  - Focusing ethical dilemmas of evidence-based practice in SMF-exposed MRI-workers: 
      a qualitative analysis.
PG  - 417-21
LID - 10.1007/s00420-009-0476-8 [doi]
AB  - PURPOSE: To analyze ethical dilemmas for occupational health physicians and other
      stakeholders involved in the implementation of a surveillance program in workers 
      exposed to static magnetic fields (SMF) used in magnetic resonance imaging.
      METHODS: The ethical analysis was carried out according to the model proposed by 
      Westerholm and others, which takes into account two elements: (i) the
      stakeholders involved in the decision process and (ii) the ethical principles of 
      beneficence, autonomy and justice. The analysis is based on the assessment of
      ethical costs (violating the consistent principle) and ethical benefits
      (fulfillment of the consistent principle) for workers, employers, occupational
      health physicians, community, workers' representatives and medical inspectors.
      RESULTS: According to the European Directive 2004/40/EC (Official Journal of the 
      European Union, Luxemburg), employers must ensure that health surveillance is
      carried out to prevent adverse health effects in SMF-exposed workers. However,
      limited scientific evidence on health effects from SMF influences the decision of
      undertaking appropriate health surveillance. The uncertainties entail a number of
      ethical conflicts, such as the choice of reliable indicators, the interpretation 
      of abnormal data, the complexity of the decision-making process resulting in a
      fitness judgment and the diversion of funds for more effective practices.
      CONCLUSIONS: The analysis shows that the decision-making process aiming at the
      provision of evidence-based health surveillance to SMF-exposed workers is
      characterized by controversial ethical costs and ethical benefits for workers and
      the other stakeholders.
FAU - Franco, Giuliano
AU  - Franco G
AD  - Dipartimento di Medicine e delle specialita mediche, Universita di Modena e
      Reggio Emilia, Largo del Pozzo, 71-41100, Modena, Italy. franco@unimo.it
FAU - Mora, Erika
AU  - Mora E
FAU - Perduri, Riccardo
AU  - Perduri R
LA  - eng
PT  - Journal Article
DEP - 20091104
PL  - Germany
TA  - Int Arch Occup Environ Health
JT  - International archives of occupational and environmental health
JID - 7512134
SB  - IM
MH  - *Allied Health Personnel
MH  - Environmental Monitoring/*ethics/standards
MH  - Evidence-Based Practice
MH  - Female
MH  - Focus Groups
MH  - Humans
MH  - Italy
MH  - *Magnetic Resonance Imaging
MH  - *Magnetics
MH  - Male
MH  - Occupational Exposure/adverse effects/*ethics/standards
MH  - Occupational Health Physicians
EDAT- 2009/11/06 06:00
MHDA- 2010/07/14 06:00
CRDT- 2009/11/06 06:00
PHST- 2009/04/27 00:00 [received]
PHST- 2009/10/16 00:00 [accepted]
PHST- 2009/11/06 06:00 [entrez]
PHST- 2009/11/06 06:00 [pubmed]
PHST- 2010/07/14 06:00 [medline]
AID - 10.1007/s00420-009-0476-8 [doi]
PST - ppublish
SO  - Int Arch Occup Environ Health. 2010 Apr;83(4):417-21. doi:
      10.1007/s00420-009-0476-8. Epub 2009 Nov 4.


PMID- 19888293
OWN - NLM
STAT- MEDLINE
DCOM- 20100629
LR  - 20211020
IS  - 1476-5438 (Electronic)
IS  - 1018-4813 (Linking)
VI  - 18
IP  - 4
DP  - 2010 Apr
TI  - Ethical implications of the use of whole genome methods in medical research.
PG  - 398-403
LID - 10.1038/ejhg.2009.191 [doi]
AB  - The use of genome-wide association studies (GWAS) in medical research and the
      increased ability to share data give a new twist to some of the perennial ethical
      issues associated with genomic research. GWAS create particular challenges
      because they produce fine, detailed, genotype information at high resolution, and
      the results of more focused studies can potentially be used to determine genetic 
      variation for a wide range of conditions and traits. The information from a GWA
      scan is derived from DNA that is a powerful personal identifier, and can provide 
      information not just on the individual, but also on the individual's relatives,
      related groups, and populations. Furthermore, it creates large amounts of
      individual-specific digital information that is easy to share across
      international borders. This paper provides an overview of some of the key ethical
      issues around GWAS: consent, feedback of results, privacy, and the governance of 
      research. Many of the questions that lie ahead of us in terms of the next
      generation sequencing methods will have been foreshadowed by GWAS and the debates
      around ethical and policy issues that these have created.
FAU - Kaye, Jane
AU  - Kaye J
AD  - Department of Public Health, Ethox Centre, University of Oxford, Headington,
      DPHPC, Old Road Campus, Headington, Oxford, Oxon OX3 7LF, UK.
      jane.kaye@ethox.ox.ac.uk
FAU - Boddington, Paula
AU  - Boddington P
FAU - de Vries, Jantina
AU  - de Vries J
FAU - Hawkins, Naomi
AU  - Hawkins N
FAU - Melham, Karen
AU  - Melham K
LA  - eng
GR  - WT 083326/Z/07/Z/WT_/Wellcome Trust/United Kingdom
GR  - WT 077869/Z/05/Z/WT_/Wellcome Trust/United Kingdom
GR  - WT 076070/Z/04/Z/WT_/Wellcome Trust/United Kingdom
GR  - WT_/Wellcome Trust/United Kingdom
GR  - 081407/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20091104
PL  - England
TA  - Eur J Hum Genet
JT  - European journal of human genetics : EJHG
JID - 9302235
SB  - IM
MH  - Biomedical Research/*ethics/legislation & jurisprudence
MH  - *Ethics, Medical
MH  - Genetic Privacy/*legislation & jurisprudence
MH  - *Genome, Human
MH  - *Genome-Wide Association Study
MH  - Humans
RF  - 27
PMC - PMC2879322
MID - UKMS29768
OID - NLM: UKMS29768
EDAT- 2009/11/06 06:00
MHDA- 2010/06/30 06:00
CRDT- 2009/11/06 06:00
PHST- 2009/11/06 06:00 [entrez]
PHST- 2009/11/06 06:00 [pubmed]
PHST- 2010/06/30 06:00 [medline]
AID - ejhg2009191 [pii]
AID - 10.1038/ejhg.2009.191 [doi]
PST - ppublish
SO  - Eur J Hum Genet. 2010 Apr;18(4):398-403. doi: 10.1038/ejhg.2009.191. Epub 2009
      Nov 4.


PMID- 19887763
OWN - NLM
STAT- MEDLINE
DCOM- 20100812
LR  - 20100430
IS  - 1423-0003 (Electronic)
IS  - 0304-324X (Linking)
VI  - 56
IP  - 3
DP  - 2010
TI  - Evaluation of participant comprehension of information received in an exercise
      and diet intervention trial: The DR's EXTRA study.
PG  - 291-7
LID - 10.1159/000254484 [doi]
AB  - BACKGROUND: The informed consent process is the legal and ethical cornerstone of 
      health research and is essential to ensure that participants in health research
      really understand the information they receive. Clinical studies often fail to
      provide data that clarify how much participants have understood. OBJECTIVE: To
      evaluate the comprehension of older volunteer participants in health research.
      METHODS: The subjects are a random population sample of 1,410 men and women aged 
      57-78 years, who are participating in a 4-year randomized controlled intervention
      trial on the effects of physical exercise and diet on atherosclerosis,
      endothelial function and cognition. A questionnaire about informed consent was
      given to all willing participants (n = 1,324) 3 months after the randomization.
      In addition, participants' long-term continuation in the intervention trial with 
      relation to understanding was evaluated 2 years after the randomization. RESULTS:
      The response rate was 91%. The majority of respondents (89%) were satisfied with 
      the intelligibility of received information. In addition, the participants'
      comprehension of the information received seemed to be adequate in 82% of the
      whole study population. Compared to background variables, higher education (p <
      0.001) and satisfaction with one's own health (p = 0.01) were associated with
      adequate comprehension of the provided information. Furthermore, participants who
      felt themselves to be healthy were more likely to continue participating in the
      intervention after 2 years. CONCLUSIONS: The findings of this study indicated
      sufficient understanding of received information in older research participants. 
      However, our results indicate that special efforts should be made with
      participants with lower educational levels or subjective feelings of impaired
      health. This study highlights the need for researchers to critically analyze the 
      quality of information and how it is provided. This is especially important in
      long-term follow-up studies.
CI  - 2009 S. Karger AG, Basel.
FAU - Lansimies-Antikainen, Helena
AU  - Lansimies-Antikainen H
AD  - Department of Nursing Science, University of Kuopio, Kuopio University Hospital, 
      Finland. ahantika@hytti.uku.fi
FAU - Pietila, Anna-Maija
AU  - Pietila AM
FAU - Kiviniemi, Vesa
AU  - Kiviniemi V
FAU - Rauramaa, Rainer
AU  - Rauramaa R
FAU - Laitinen, Tomi
AU  - Laitinen T
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20091030
PL  - Switzerland
TA  - Gerontology
JT  - Gerontology
JID - 7601655
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Atherosclerosis/psychology/therapy
MH  - Cognition
MH  - *Comprehension
MH  - *Diet
MH  - *Disclosure
MH  - Educational Status
MH  - Endothelium, Vascular
MH  - *Exercise
MH  - Female
MH  - Humans
MH  - Informed Consent/psychology
MH  - Male
MH  - Middle Aged
MH  - *Patient Education as Topic
MH  - *Patient Satisfaction
EDAT- 2009/11/06 06:00
MHDA- 2010/08/13 06:00
CRDT- 2009/11/06 06:00
PHST- 2009/04/27 00:00 [received]
PHST- 2009/06/25 00:00 [accepted]
PHST- 2009/11/06 06:00 [entrez]
PHST- 2009/11/06 06:00 [pubmed]
PHST- 2010/08/13 06:00 [medline]
AID - 000254484 [pii]
AID - 10.1159/000254484 [doi]
PST - ppublish
SO  - Gerontology. 2010;56(3):291-7. doi: 10.1159/000254484. Epub 2009 Oct 30.


PMID- 19886898
OWN - NLM
STAT- MEDLINE
DCOM- 20100128
LR  - 20091216
IS  - 1651-2227 (Electronic)
IS  - 0803-5253 (Linking)
VI  - 99
IP  - 1
DP  - 2010 Jan
TI  - Recommendations for an ethical treatment of newborns involved in clinical trials.
PG  - 30-2
LID - 10.1111/j.1651-2227.2009.01570.x [doi]
FAU - Bellieni, C V
AU  - Bellieni CV
AD  - Department of Pediatrics, Obstetrics and Reproductive Medicine, University of
      Siena, Siena, Italy. bellieni@iol.it
FAU - Buonocore, G
AU  - Buonocore G
LA  - eng
PT  - Journal Article
PL  - Norway
TA  - Acta Paediatr
JT  - Acta paediatrica (Oslo, Norway : 1992)
JID - 9205968
RN  - 0 (Placebos)
SB  - IM
MH  - Analgesia/ethics
MH  - Blood Specimen Collection/ethics/standards
MH  - Clinical Trials as Topic/*ethics/standards
MH  - Editorial Policies
MH  - *Guidelines as Topic
MH  - Humans
MH  - *Infant, Newborn
MH  - Placebos
MH  - Stress, Physiological
EDAT- 2009/11/06 06:00
MHDA- 2010/01/29 06:00
CRDT- 2009/11/06 06:00
PHST- 2009/11/06 06:00 [entrez]
PHST- 2009/11/06 06:00 [pubmed]
PHST- 2010/01/29 06:00 [medline]
AID - APA1570 [pii]
AID - 10.1111/j.1651-2227.2009.01570.x [doi]
PST - ppublish
SO  - Acta Paediatr. 2010 Jan;99(1):30-2. doi: 10.1111/j.1651-2227.2009.01570.x.


PMID- 19886878
OWN - NLM
STAT- MEDLINE
DCOM- 20110324
LR  - 20161125
IS  - 1742-1241 (Electronic)
IS  - 1368-5031 (Linking)
VI  - 64
IP  - 2
DP  - 2010 Jan
TI  - The ethics of British professional homoeopaths.
PG  - 147-8
LID - 10.1111/j.1742-1241.2009.02249.x [doi]
FAU - Ernst, E
AU  - Ernst E
AD  - Complementary Medicine, Peninsula Medical School, Universities of Exeter &
      Plymouth, 25 Victoria Park Road, Exeter EX2 4NT, UK. Edzard.Ernst@pms.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20091103
PL  - India
TA  - Int J Clin Pract
JT  - International journal of clinical practice
JID - 9712381
SB  - IM
MH  - *Ethics, Professional
MH  - Homeopathy/*ethics
MH  - Humans
MH  - United Kingdom
EDAT- 2009/11/06 06:00
MHDA- 2011/03/25 06:00
CRDT- 2009/11/06 06:00
PHST- 2009/11/06 06:00 [entrez]
PHST- 2009/11/06 06:00 [pubmed]
PHST- 2011/03/25 06:00 [medline]
AID - IJCP2249 [pii]
AID - 10.1111/j.1742-1241.2009.02249.x [doi]
PST - ppublish
SO  - Int J Clin Pract. 2010 Jan;64(2):147-8. doi: 10.1111/j.1742-1241.2009.02249.x.
      Epub 2009 Nov 3.


PMID- 19885745
OWN - NLM
STAT- MEDLINE
DCOM- 20110210
LR  - 20100810
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 16
IP  - 3
DP  - 2010 Sep
TI  - The responsible subject in the global age.
PG  - 447-61
LID - 10.1007/s11948-009-9175-9 [doi]
AB  - The first thesis of this article is that the concept of responsibility takes on
      an unprecedented meaning in the twentieth century resulting from the emergence of
      a new dimension of the other: to be responsible comes to mean not just to account
      for oneself in relation to the other, but also to take the other into account, to
      take care of the other-what I call responsibility towards (the other). The main
      reason for this change consists in the emergence of global risks and the
      necessity, as underlined by Hans Jonas, to be responsible for the destiny of the 
      world and future generations. The problem, as explored in the article's second
      thesis, is that this implies the existence of a subject who is capable of
      responsibility. Jonas's insights on this point are insufficient, since he only
      recognizes duty as the fundament for his ethics of responsibility and thus
      neglects the problem of motivation. This is a particularly crucial problem today 
      as we are witnessing the presence of a pathological subject, characterized by a
      split in his faculties (between doing and imagining, knowing and feeling). To
      underline this fact, this article makes use of Gunther Anders's reflections,
      which provide a psycho-anthropological analysis of the subject, showing his
      pathologies and the necessity, from a moral perspective, to overcome his
      scission. Finally, this author suggests, as the article's third thesis, that this
      overcoming is the necessary fundament for the perception of risk, which in turn
      reinstates the subject's perception of his own vulnerability. Responsibility thus
      finds a motivation, which is neither altruistic nor duty-centred, in the
      awareness of our own vulnerability and the bond with the destiny of humankind as 
      a whole.
FAU - Pulcini, Elena
AU  - Pulcini E
AD  - Dipartimento di Filosofia, University of Florence, Via Bolognese 52, 50139,
      Florence, Italy. elenapulcini@gmail.it
LA  - eng
PT  - Journal Article
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Anthropology
MH  - *Ethics
MH  - Germany
MH  - Humans
MH  - Mental Processes
MH  - *Motivation
MH  - Psychology
MH  - Risk
MH  - *Safety
MH  - Self Concept
EDAT- 2009/11/04 06:00
MHDA- 2011/02/11 06:00
CRDT- 2009/11/04 06:00
PHST- 2009/11/04 06:00 [entrez]
PHST- 2009/11/04 06:00 [pubmed]
PHST- 2011/02/11 06:00 [medline]
AID - 10.1007/s11948-009-9175-9 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2010 Sep;16(3):447-61. doi: 10.1007/s11948-009-9175-9.


PMID- 19883970
OWN - NLM
STAT- MEDLINE
DCOM- 20100622
LR  - 20181201
IS  - 1432-0436 (Electronic)
IS  - 0301-4681 (Linking)
VI  - 79
IP  - 2
DP  - 2010 Feb
TI  - Commitment of stem cells into functional hepatocytes.
PG  - 65-73
LID - 10.1016/j.diff.2009.10.002 [doi]
AB  - Liver transplants represent the only way to treat patients suffering from
      terminal liver failure, but they are associated with numerous problems, including
      a chronic shortage of donors, high cost, rejection, and side effects for the
      donor. It is anticipated that regenerative medicine will provide an alternative
      to liver transplants for such patients. Regenerative medicine refers to the
      academic field of eliciting the inherent capacity of organisms for
      self-regeneration to the greatest possible extent in order to develop new methods
      of treatment for intractable disorders. From this perspective, much is expected
      from the use of human embryonic stem cells (ES cells) or induced pluripotent stem
      cells (iPS cells), and the vigorous development of technology to induce the
      differentiation of such stem cells into cells possessing hepatic functions is
      underway. Clinical applications of these human stem cells, however, have yet to
      reach even the earliest stages of implementation. Facing off against these
      versatile ES cells are stem cells derived from somatic cells present within
      organisms, which are attracting attention owing to their superiority in terms of 
      ethics and safety, with many research institutes now in the process of
      elucidating the details of stem cell separation and identification as well as
      their plasticity and pluripotency. Bone marrow cells are the best-known
      somatic-cell-derived stem cells, but the use of mesenchymal stem cells (MSCs)
      found in adipose tissue has also recently attracted attention. This paper will
      review the differentiation ability and mechanisms of these various stem cell
      types to hepatocytes and their application to liver regeneration and the future
      outlook.
CI  - 2009 International Society of Differentiation. Published by Elsevier B.V. All
      rights reserved.
FAU - Ochiya, Takahiro
AU  - Ochiya T
AD  - National Cancer Center Research Institute, Tsukiji, Chuoku, Tokyo, Japan.
      tochiya@ncc.go.jp
FAU - Yamamoto, Yusuke
AU  - Yamamoto Y
FAU - Banas, Agnieszka
AU  - Banas A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20091101
PL  - England
TA  - Differentiation
JT  - Differentiation; research in biological diversity
JID - 0401650
SB  - IM
MH  - Animals
MH  - Cell Differentiation
MH  - Embryonic Stem Cells/cytology/metabolism/transplantation
MH  - Hepatocytes/cytology/*metabolism
MH  - Humans
MH  - Liver/metabolism
MH  - Liver Regeneration
MH  - Mesenchymal Stem Cells/metabolism
MH  - Mice
MH  - Regenerative Medicine
MH  - Stem Cell Transplantation
MH  - Stem Cells/*cytology/metabolism
RF  - 29
EDAT- 2009/11/04 06:00
MHDA- 2010/06/23 06:00
CRDT- 2009/11/04 06:00
PHST- 2009/02/04 00:00 [received]
PHST- 2009/07/14 00:00 [revised]
PHST- 2009/10/09 00:00 [accepted]
PHST- 2009/11/04 06:00 [entrez]
PHST- 2009/11/04 06:00 [pubmed]
PHST- 2010/06/23 06:00 [medline]
AID - S0301-4681(09)00114-5 [pii]
AID - 10.1016/j.diff.2009.10.002 [doi]
PST - ppublish
SO  - Differentiation. 2010 Feb;79(2):65-73. doi: 10.1016/j.diff.2009.10.002. Epub 2009
      Nov 1.


PMID- 19883749
OWN - NLM
STAT- MEDLINE
DCOM- 20100602
LR  - 20100222
IS  - 1879-3177 (Electronic)
IS  - 0887-2333 (Linking)
VI  - 24
IP  - 2
DP  - 2010 Mar
TI  - Use of in vitro testing to identify an unexpected skin sensitizing impurity in a 
      commercial product: a case study.
PG  - 411-6
LID - 10.1016/j.tiv.2009.10.015 [doi]
AB  - Due to regulatory constraints and ethical considerations, the quest for
      alternatives to animal testing has gained a new momentum. In general, animal
      welfare considerations and compliance with regulations are the key drivers for
      this research. Mechanistically based in vitro tests addressing specific
      toxicological questions can yield new information, for example on reactive
      components, and thus in certain cases the in vitro tests are not only second
      choice replacements of a 'gold standard' animal test but can also be used to
      develop safer products. Here we report a case study from the in vitro
      investigation on the commercial fragrance chemical Azurone. This compound was
      found to be a moderate skin sensitizer in the LLNA, whereas the structurally
      closely similar compound Calone is a non-sensitizer. A peptide reactivity assay
      indicated, that indeed Azurone yields peptide depletion, thus the in vitro assays
      confirmed the animal test result. LC-MS analysis of the peptide reactivity sample
      showed the presence of peptide adducts of unexpected molecular weight. They were 
      consistent with the reaction of the peptide with a catechol related to Azurone.
      Detailed analytics indicated that indeed this catechol is present in the original
      batches as an impurity, but it has escaped quality control analysis, as it is not
      detectable in routine GC-analysis. A new purified batch was prepared, re-tested
      in the in vitro assays and predicted by the tests to be a non-sensitizer. A
      confirmatory LLNA test indeed yielded a significantly (10-fold) higher EC3 value 
      of the new batch, but the LLNA was still positive. A dose-response study in the
      EpiSkin assay indicated that this molecule still has a significant skin
      irritation potential, which may generate the weak positive signal in the LLNA.
      This case study illustrates how the mechanistically based in vitro LC-MS peptide 
      reactivity assay can be used to contribute to the understanding of the
      sensitization mechanism of a commercial product and help to define a safer
      product specification.
CI  - Copyright (c) 2009 Elsevier Ltd. All rights reserved.
FAU - Natsch, Andreas
AU  - Natsch A
AD  - Givaudan Schweiz AG, Ueberlandstrasse 138, CH-8600 Duebendorf, Switzerland.
      Andreas.natsch@givaudan.com
FAU - Gfeller, Hans
AU  - Gfeller H
FAU - Emter, Roger
AU  - Emter R
FAU - Ellis, Graham
AU  - Ellis G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091031
PL  - England
TA  - Toxicol In Vitro
JT  - Toxicology in vitro : an international journal published in association with
      BIBRA
JID - 8712158
RN  - 0 (4-isoamylbenzene-1,2-diol)
RN  - 0 (7-isopentyl-2H-benzo(b)(1,4)dioxepin-7(4H)-one)
RN  - 0 (Benzoxepins)
RN  - 0 (Catechols)
RN  - 0 (Peptides)
RN  - 0 (Perfume)
RN  - 0 (calone)
RN  - 33515-09-2 (Gonadotropin-Releasing Hormone)
RN  - 87565-51-3 (MI 1544)
SB  - IM
MH  - Animal Testing Alternatives/methods
MH  - Animals
MH  - Benzoxepins/chemistry/toxicity
MH  - Catechols/chemistry/toxicity
MH  - Dermatitis, Allergic Contact/*etiology
MH  - Gonadotropin-Releasing Hormone/analogs & derivatives
MH  - Local Lymph Node Assay
MH  - *Peptides/chemistry/toxicity
MH  - Perfume/toxicity
MH  - Skin Irritancy Tests/*methods
EDAT- 2009/11/04 06:00
MHDA- 2010/06/03 06:00
CRDT- 2009/11/04 06:00
PHST- 2009/09/21 00:00 [received]
PHST- 2009/10/23 00:00 [revised]
PHST- 2009/10/26 00:00 [accepted]
PHST- 2009/11/04 06:00 [entrez]
PHST- 2009/11/04 06:00 [pubmed]
PHST- 2010/06/03 06:00 [medline]
AID - S0887-2333(09)00324-5 [pii]
AID - 10.1016/j.tiv.2009.10.015 [doi]
PST - ppublish
SO  - Toxicol In Vitro. 2010 Mar;24(2):411-6. doi: 10.1016/j.tiv.2009.10.015. Epub 2009
      Oct 31.


PMID- 19882469
OWN - NLM
STAT- MEDLINE
DCOM- 20100303
LR  - 20091223
IS  - 1744-4144 (Electronic)
IS  - 1385-4046 (Linking)
VI  - 24
IP  - 1
DP  - 2010 Jan
TI  - Determining whether or when to adopt new versions of psychological and
      neuropsychological tests: ethical and professional considerations.
PG  - 7-16
LID - 10.1080/13854040903313589 [doi]
AB  - Test selection has significant implications for inferences that can be drawn from
      test data. Some tests undergo revisions, typically to improve their psychometric 
      properties, normative data, relevance of stimuli, and ease of administration.
      Although revisions of psychological and neuropsychological tests are published
      periodically, little information is available regarding whether or when
      clinicians should transition to the most recent versions of the tests. The 2002
      APA Ethics Code (Standard 9.08b) requires that psychologists not base their
      assessment or intervention decisions or recommendations "on tests and measures
      that are obsolete and not useful for the current purpose." However, there is no
      consensus regarding when tests should no longer be considered acceptable, and
      there may be sound reasons for delaying or foregoing the purchase and use of new 
      versions of assessment measures. Determining whether or when to transition to a
      new version of a test can be particularly difficult for clinicians in
      psychological specialties because it can take years after publication of a
      revised test for research with special patient populations to be performed and
      published. As a result, different clinicians may adopt newer versions of tests at
      different times or elect not to use the newest version, depending on the specific
      patient population and referral questions. Decisions regarding transitioning to
      new test revisions should be based on the scientific merits of the tests, not on 
      an arbitrarily defined time frame. Clinicians ultimately must use their judgment 
      regarding which test version is best for a given patient at a given point in
      time.
FAU - Bush, Shane S
AU  - Bush SS
AD  - Long Island Neuropsychology, P.C., Lake Ronkonkoma, NY 11779, USA.
      Neuropsych@ShaneBush.com
LA  - eng
PT  - Journal Article
DEP - 20091027
PL  - England
TA  - Clin Neuropsychol
JT  - The Clinical neuropsychologist
JID - 8806548
SB  - IM
MH  - Guidelines as Topic
MH  - Humans
MH  - *Neuropsychological Tests
MH  - Neuropsychology/*ethics/legislation & jurisprudence
MH  - *Psychological Tests
MH  - Reproducibility of Results
EDAT- 2009/11/03 06:00
MHDA- 2010/03/04 06:00
CRDT- 2009/11/03 06:00
PHST- 2009/11/03 06:00 [entrez]
PHST- 2009/11/03 06:00 [pubmed]
PHST- 2010/03/04 06:00 [medline]
AID - 916406946 [pii]
AID - 10.1080/13854040903313589 [doi]
PST - ppublish
SO  - Clin Neuropsychol. 2010 Jan;24(1):7-16. doi: 10.1080/13854040903313589. Epub 2009
      Oct 27.


PMID- 19879201
OWN - NLM
STAT- MEDLINE
DCOM- 20101014
LR  - 20131121
IS  - 1878-0539 (Electronic)
IS  - 1748-6815 (Linking)
VI  - 63
IP  - 10
DP  - 2010 Oct
TI  - Augmentation of temporal fossa hollowing with Mersilene mesh.
PG  - 1629-34
LID - 10.1016/j.bjps.2009.09.022 [doi]
AB  - PURPOSE: Temporal fossa hollowing can represent a serious cosmetic concern to
      patients', whether congenital; part of a post-traumatic deformity; following
      oncological resection; or following orbital decompression procedures. Various
      methods have been described to augment the defect including high density
      polyethylene (HDPE) implants, methyl methylmethacrolate and lipotransfer, but all
      have their relative drawbacks. METHODS: We describe 13 temporal defects in 10
      patients whose defects have been reconstructed with Mersilene mesh (Ethicon,
      Livingstone UK). When the temporalis muscle is still adequately suspended; folded
      mesh can be placed in a submuscular/subperiosteal plane. The mesh can be folded
      as many times as necessary to recreate the appropriate volume, thereby allowing
      fine control of temple width. If the temporalis is attenuated or displaced
      inferiorly by previous surgery, its insertion can be recreated using titanium
      screws to attach the mesh superiorly to the appropriate site on the cranium; the 
      temporalis resuspended and the fascia sutured to the mesh. RESULTS: We report
      very pleasing cosmetic results with no associated complications such as implant, 
      extrusion or exposure. One patient was complicated by infection requiring removal
      of the mesh as well as titanium cranioplasty, screws and plates. CONCLUSION:
      Mersilene mesh is easy to use, contours naturally to the defect and is
      considerably cheaper than alternatives like HDPE implants.
CI  - Copyright 2009 British Association of Plastic, Reconstructive and Aesthetic
      Surgeons. Published by Elsevier Ltd. All rights reserved.
FAU - Atherton, Duncan Donald
AU  - Atherton DD
AD  - Chelsea and Westminster Hospital Craniofacial Unit, 369 Fulham Road, London SW10 
      9NH, UK. duncanatherton@hotmail.co.uk
FAU - Joshi, Naresh
AU  - Joshi N
FAU - Kirkpatrick, Niall
AU  - Kirkpatrick N
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20091029
PL  - Netherlands
TA  - J Plast Reconstr Aesthet Surg
JT  - Journal of plastic, reconstructive & aesthetic surgery : JPRAS
JID - 101264239
RN  - 0 (Polyethylene Terephthalates)
RN  - 25038-59-9 (Lavsan)
RN  - D1JT611TNE (Titanium)
SB  - IM
MH  - Adult
MH  - Bone Plates
MH  - Bone Screws
MH  - Carcinoma, Adenoid Cystic/pathology/*surgery
MH  - Female
MH  - Graves Ophthalmopathy/*surgery
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polyethylene Terephthalates
MH  - Reconstructive Surgical Procedures/*methods
MH  - *Surgical Mesh
MH  - Temporal Bone/injuries/pathology/*surgery
MH  - Titanium
MH  - Treatment Outcome
EDAT- 2009/11/03 06:00
MHDA- 2010/10/15 06:00
CRDT- 2009/11/03 06:00
PHST- 2009/07/27 00:00 [received]
PHST- 2009/09/20 00:00 [accepted]
PHST- 2009/11/03 06:00 [entrez]
PHST- 2009/11/03 06:00 [pubmed]
PHST- 2010/10/15 06:00 [medline]
AID - S1748-6815(09)00719-0 [pii]
AID - 10.1016/j.bjps.2009.09.022 [doi]
PST - ppublish
SO  - J Plast Reconstr Aesthet Surg. 2010 Oct;63(10):1629-34. doi:
      10.1016/j.bjps.2009.09.022. Epub 2009 Oct 29.


PMID- 19878237
OWN - NLM
STAT- MEDLINE
DCOM- 20100824
LR  - 20100524
IS  - 1523-1739 (Electronic)
IS  - 0888-8892 (Linking)
VI  - 24
IP  - 2
DP  - 2010 Apr
TI  - The value of species and the ethical foundations of assisted colonization.
PG  - 424-31
LID - 10.1111/j.1523-1739.2009.01351.x [doi]
AB  - Discourse around assisted colonization focuses on the ecological risks, costs,
      and uncertainties associated with the practice, as well as on its technical
      feasibility and alternative approaches to it. Nevertheless, the ethical
      underpinnings of the case for assisted colonization are claims about the value of
      species. A complete discussion of assisted colonization needs to include
      assessment of these claims. For each type of value that species are thought to
      possess it is necessary to determine whether it is plausible that species possess
      the type of value and, if so, to what extent their possessing it justifies
      assisted colonization. I conducted such an assessment for each of the predominant
      types of value ascribed to species: ecological, instrumental (including option
      value), existence, and intrinsic value (including interest-based, objective, and 
      valuer-dependent intrinsic value). The vast majority of species, including
      several that have been proposed as candidates for assisted colonization, have
      much less value than is often presumed. Moreover, with respect to some types of
      value, assisted colonization would not fully preserve the value of the target
      species even if it were to keep the target species in existence. Therefore, the
      case for assisted colonization is significantly weaker and more qualified than
      its advocates often suppose. There may be exceptional species for which assisted 
      colonization is well justified--and for this reason, case-by-case assessment is
      necessary--but in general the burden of justification generated by the ecological
      risks associated with assisted colonization is not met by the value potentially
      preserved by assisted colonization. This suggests that assisted colonization
      ought to have, at most, a very minor role in the portfolio of ecosystem
      management practices, even as it pertains to species conservation under
      conditions of rapid climate change.
FAU - Sandler, Ronald
AU  - Sandler R
AD  - Department of Philosophy and Religion, Northeastern University, 371 Holmes Hall, 
      Boston, MA 02115-5000, USA. r.sandler@neu.edu
LA  - eng
PT  - Journal Article
DEP - 20091028
PL  - United States
TA  - Conserv Biol
JT  - Conservation biology : the journal of the Society for Conservation Biology
JID - 9882301
SB  - IM
MH  - *Animal Migration
MH  - Animals
MH  - Conservation of Natural Resources/*methods
MH  - Ecology/*ethics
MH  - *Endangered Species
MH  - *Extinction, Biological
MH  - Humans
EDAT- 2009/11/03 06:00
MHDA- 2010/08/25 06:00
CRDT- 2009/11/03 06:00
PHST- 2009/11/03 06:00 [entrez]
PHST- 2009/11/03 06:00 [pubmed]
PHST- 2010/08/25 06:00 [medline]
AID - CBI1351 [pii]
AID - 10.1111/j.1523-1739.2009.01351.x [doi]
PST - ppublish
SO  - Conserv Biol. 2010 Apr;24(2):424-31. doi: 10.1111/j.1523-1739.2009.01351.x. Epub 
      2009 Oct 28.


PMID- 19877260
OWN - NLM
STAT- MEDLINE
DCOM- 20100111
LR  - 20091224
IS  - 1531-4995 (Electronic)
IS  - 0023-852X (Linking)
VI  - 120
IP  - 1
DP  - 2010 Jan
TI  - Eco-conservation and healthcare ethics: a call to action.
PG  - 4-8
LID - 10.1002/lary.20663 [doi]
FAU - Cotton, Robin T
AU  - Cotton RT
AD  - Division of Pediatric Otolaryngology-Head and Neck Surgery, Cincinnati Children's
      Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA. robin.cotton@cchmc.org
FAU - Cohen, Aliza P
AU  - Cohen AP
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
RN  - 0 (Medical Waste)
SB  - IM
MH  - Climate Change
MH  - Conservation of Energy Resources
MH  - *Conservation of Natural Resources
MH  - *Delivery of Health Care
MH  - Environmental Pollution/*prevention & control
MH  - Ethics, Medical
MH  - Medical Waste
EDAT- 2009/10/31 06:00
MHDA- 2010/01/12 06:00
CRDT- 2009/10/31 06:00
PHST- 2009/10/31 06:00 [entrez]
PHST- 2009/10/31 06:00 [pubmed]
PHST- 2010/01/12 06:00 [medline]
AID - 10.1002/lary.20663 [doi]
PST - ppublish
SO  - Laryngoscope. 2010 Jan;120(1):4-8. doi: 10.1002/lary.20663.


PMID- 19877194
OWN - NLM
STAT- MEDLINE
DCOM- 20100111
LR  - 20141120
IS  - 1531-4995 (Electronic)
IS  - 0023-852X (Linking)
VI  - 120
IP  - 1
DP  - 2010 Jan
TI  - Transoral resection of short segment Zenker's diverticulum and cricopharyngeal
      myotomy: an alternative minimally invasive approach.
PG  - 17-22
LID - 10.1002/lary.20657 [doi]
AB  - OBJECTIVES/HYPOTHESIS: Transoral treatment of cricopharyngeal bar and small
      Zenker's diverticulum remains a challenge. We propose a new transoral approach
      for transoral cricopharyngeal myotomy (TOCPM) for patients with cricopharyngeal
      spasm and pharyngeal bar, and for transoral resection of diverticula (TORD) with 
      cricopharyngeal myotomy in the patient with small (<3 cm) Zenker's diverticulum. 
      METHODS: A retrospective review was conducted of 45 patients with cricopharyngeal
      spasm (21) and Zenker's diverticulum (24), where 14 patients were considered
      suitable for TORD and TOCPM. TOCPM used the Weerda laryngoscope (Karl Storz,
      Tuttlingen, Germany) to expose the cricopharyngeal bar using a microscope; the
      mucosa is cut and then the muscle is transected using monopolar cautery. A 0
      degrees endoscope is inserted through the incision to ensure complete myotomy.
      Incision closure is by interrupted 4-0 Vicryl sutures (Ethicon Inc., Somerville, 
      NJ) and fibrin glue. For the TORD procedure, the diverticular sac is everted and 
      then resected using scissors. Through the sac opening, the TOCPM is completed.
      The sac opening is then closed as described in TOCPM. The patients are kept
      without food for 24 hours, followed by feeding and discharge. Modified barium
      swallow (MBS) evaluated functional results. RESULTS: Fourteen patients underwent 
      TOCPM (eight), and TOCPM+TORD (six). There was one case of TOCPM that was aborted
      due to excessive bleeding, which prevented full myotomy. The rest did well. All
      were discharged the next day. Two poor results from the TOCPM and TOCPM+TORD
      group were due to poor esophageal motility. The remainder of patients had
      resolution of dysphagia and normalized MBS. No patient developed stricture or
      complications. CONCLUSIONS: Short segment Zenker's diverticulum and
      cricopharyngeal bar can now be addressed completely with a transoral approach.
      Because there is complete closure of the mucosal incision, prolonged
      hospitalization can be avoided.
FAU - Mortensen, Melissa
AU  - Mortensen M
AD  - University of Virginia Health System, Department of Otolaryngology-Head and Neck 
      Surgery, Charlottesville, Virginia, USA.
FAU - Schaberg, Madeleine R
AU  - Schaberg MR
FAU - Genden, Eric M
AU  - Genden EM
FAU - Woo, Peak
AU  - Woo P
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
SB  - IM
CIN - Laryngoscope. 2010 Apr;120(4):865; author reply 866. PMID: 20104477
MH  - Deglutition Disorders/surgery
MH  - Diverticulitis/*surgery
MH  - Humans
MH  - Laryngeal Muscles/*surgery
MH  - Laryngismus/*surgery
MH  - *Laryngoscopy
MH  - Minimally Invasive Surgical Procedures/*methods
MH  - Mouth
MH  - Retrospective Studies
MH  - Treatment Outcome
MH  - Zenker Diverticulum/*surgery
EDAT- 2009/10/31 06:00
MHDA- 2010/01/12 06:00
CRDT- 2009/10/31 06:00
PHST- 2009/10/31 06:00 [entrez]
PHST- 2009/10/31 06:00 [pubmed]
PHST- 2010/01/12 06:00 [medline]
AID - 10.1002/lary.20657 [doi]
PST - ppublish
SO  - Laryngoscope. 2010 Jan;120(1):17-22. doi: 10.1002/lary.20657.


PMID- 19875204
OWN - NLM
STAT- MEDLINE
DCOM- 20100901
LR  - 20211020
IS  - 1578-1275 (Electronic)
IS  - 0212-6567 (Linking)
VI  - 42
IP  - 5
DP  - 2010 May
TI  - [Concept and applications of the Web 3.0: an introduction for medical doctors].
PG  - 292-6
LID - 10.1016/j.aprim.2009.06.025 [doi]
AB  - The development of the Internet is continuous and appears to be never-ending,
      although with the arrival of Web 3.0 it could be said that the Internet is what
      its creators intended it to be from the first moment, an extraordinary and
      immense organised, understandable, and easy to access data base, characteristics 
      still not achieved. The innovations and services included in Web 3.0 will result,
      in the first place, in better, faster and safer access to quality information. In
      the second place it should provide better personalisation of the health services 
      that Internet users access, avoiding irrelevant information that may contain
      wrong, false and dangerous recommendations. However, these changes will have to
      be accompanied by the legal requirements common to the information society, by
      the ethical aspects associated with medical care, guaranteeing and contributing, 
      in all cases, to improving the doctor-patient relationship.
CI  - Copyright 2009 Elsevier Espana, S.L. All rights reserved.
FAU - Mayer, Miguel Angel
AU  - Mayer MA
AD  - Departamento de Web Medica Acreditada, Colegio Oficial de Medicos, Barcelona,
      Espana. mmayer.wma@comb.cat
FAU - Leis, Angela
AU  - Leis A
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Concepto y aplicaciones de la Web 3.0: una introduccion para medicos.
DEP - 20091028
PL  - Spain
TA  - Aten Primaria
JT  - Atencion primaria
JID - 9111075
SB  - IM
MH  - *Internet
MH  - *Medicine
MH  - Physicians
MH  - Vocabulary, Controlled
PMC - PMC7024466
EDAT- 2009/10/31 06:00
MHDA- 2010/09/02 06:00
CRDT- 2009/10/31 06:00
PHST- 2009/06/03 00:00 [received]
PHST- 2009/06/08 00:00 [revised]
PHST- 2009/06/08 00:00 [accepted]
PHST- 2009/10/31 06:00 [entrez]
PHST- 2009/10/31 06:00 [pubmed]
PHST- 2010/09/02 06:00 [medline]
AID - S0212-6567(09)00508-3 [pii]
AID - 10.1016/j.aprim.2009.06.025 [doi]
PST - ppublish
SO  - Aten Primaria. 2010 May;42(5):292-6. doi: 10.1016/j.aprim.2009.06.025. Epub 2009 
      Oct 28.


PMID- 19866236
OWN - NLM
STAT- MEDLINE
DCOM- 20100817
LR  - 20211020
IS  - 1432-2218 (Electronic)
IS  - 0930-2794 (Linking)
VI  - 24
IP  - 5
DP  - 2010 May
TI  - Ergonomics of disposable handles for minimally invasive surgery.
PG  - 992-1004
LID - 10.1007/s00464-009-0714-x [doi]
AB  - BACKGROUND: The ergonomic deficiencies of currently available minimally invasive 
      surgery (MIS) instrument handles have been addressed in many studies. In this
      study, a new ergonomic pistol handle concept, realized as a prototype, and two
      disposable ring handles were investigated according to ergonomic properties set
      by new European standards. METHODS: In this study, 25 volunteers performed four
      practical tasks to evaluate the ergonomics of the handles used in standard
      operating procedures (e.g., measuring a suture and cutting to length, precise
      maneuvering and targeting, and dissection of a gallbladder). Moreover, 20
      participants underwent electromyography (EMG) tests to measure the muscle strain 
      they experienced while carrying out the basic functions (grasp, rotate, and
      maneuver) in the x, y, and z axes. The data measured included the number of
      errors, the time required for task completion, perception of pressure areas, and 
      EMG data. The values for usability in the test were effectiveness, efficiency,
      and user satisfaction. Surveys relating to the subjective rating were completed
      after each task for each of the three handles tested. RESULTS: Each handle except
      the new prototype caused pressure areas and pain. Extreme differences in muscle
      strain could not be observed for any of the three handles. Experienced surgeons
      worked more quickly with the prototype when measuring and cutting a suture
      (approximately 20%) and during precise maneuvering and targeting (approximately
      20%). On the other hand, they completed the dissection task faster with the
      handle manufactured by Ethicon. Fewer errors were made with the prototype in
      dissection of the gallbladder. In contrast to the handles available on the
      market, the prototype was always rated as positive by the volunteers in the
      subjective surveys. CONCLUSIONS: None of the handles could fulfil all of the
      requirements with top scores. Each handle had its advantages and disadvantages.
      In contrast to the ring handles, the volunteers could fulfil most of the tasks
      more efficiently using the prototype handle without any remarkable pressure
      areas, cramps, or pain.
FAU - Buchel, D
AU  - Buchel D
AD  - Experimental OR and Ergonomics, University Hospital of Tubingen,
      Ernst-Simon-Strasse 16, 72072 Tubingen, Germany. dirk.buechel@experimental-op.de
FAU - Marvik, R
AU  - Marvik R
FAU - Hallabrin, B
AU  - Hallabrin B
FAU - Matern, U
AU  - Matern U
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20091029
PL  - Germany
TA  - Surg Endosc
JT  - Surgical endoscopy
JID - 8806653
SB  - IM
MH  - Disposable Equipment/*standards
MH  - Electromyography
MH  - Equipment Design
MH  - Ergonomics/*standards
MH  - Female
MH  - Hand/*anatomy & histology/physiology
MH  - Humans
MH  - Male
MH  - Minimally Invasive Surgical Procedures/*instrumentation
MH  - Muscle Fatigue/*physiology
MH  - Muscle, Skeletal/physiology
MH  - Reference Values
MH  - Surgical Instruments/*standards
MH  - Task Performance and Analysis
MH  - Time Factors
EDAT- 2009/10/30 06:00
MHDA- 2010/08/18 06:00
CRDT- 2009/10/30 06:00
PHST- 2009/03/04 00:00 [received]
PHST- 2009/09/20 00:00 [accepted]
PHST- 2009/10/30 06:00 [entrez]
PHST- 2009/10/30 06:00 [pubmed]
PHST- 2010/08/18 06:00 [medline]
AID - 10.1007/s00464-009-0714-x [doi]
PST - ppublish
SO  - Surg Endosc. 2010 May;24(5):992-1004. doi: 10.1007/s00464-009-0714-x. Epub 2009
      Oct 29.


PMID- 19863545
OWN - NLM
STAT- MEDLINE
DCOM- 20100706
LR  - 20100507
IS  - 1399-0004 (Electronic)
IS  - 0009-9163 (Linking)
VI  - 77
IP  - 3
DP  - 2010 Mar
TI  - Sudden death: ethical and legal problems of post-mortem forensic genetic testing 
      for hereditary cardiac diseases.
PG  - 287-92
LID - 10.1111/j.1399-0004.2009.01293.x [doi]
AB  - Hereditary non-structural diseases such as catecholaminergic polymorphic
      ventricular tachycardia (CPVT), long QT, and the Brugada syndrome as well as
      structural disease such as hypertrophic cardiomyopathy (HCM) and arrhythmogenic
      right ventricular cardiomyopathy (ARVC) cause a significant percentage of sudden 
      cardiac deaths in the young. In these cases, genetic testing can be useful and
      does not require proxy consent if it is carried out at the request of judicial
      authorities as part of a forensic death investigation. Mutations in several genes
      are implicated in arrhythmic syndromes, including SCN5A, KCNQ1, KCNH2, RyR2, and 
      genes causing HCM. If the victim's test is positive, this information is
      important for relatives who might be themselves at risk of carrying the
      disease-causing mutation. There is no consensus about how professionals should
      proceed in this context. This article discusses the ethical and legal arguments
      in favour of and against three options: genetic testing of the deceased victim
      only; counselling of relatives before testing the victim; counselling restricted 
      to relatives of victims who tested positive for mutations of serious and
      preventable diseases. Legal cases are mentioned that pertain to the duty of
      geneticists and other physicians to warn relatives. Although the claim for a
      legal duty is tenuous, recent publications and guidelines suggest that
      geneticists and others involved in the multidisciplinary approach of sudden death
      (SD) cases may, nevertheless, have an ethical duty to inform relatives of SD
      victims. Several practical problems remain pertaining to the costs of testing,
      the counselling and to the need to obtain permission of judicial authorities.
FAU - Elger, B S
AU  - Elger BS
AD  - Unite de droit medical et d'ethique clinique, University of Geneva, Geneva 1211, 
      Switzerland. Bernice.Elger@unige.ch
FAU - Michaud, K
AU  - Michaud K
FAU - Fellmann, F
AU  - Fellmann F
FAU - Mangin, P
AU  - Mangin P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091023
PL  - Denmark
TA  - Clin Genet
JT  - Clinical genetics
JID - 0253664
SB  - IM
MH  - Death, Sudden, Cardiac/*etiology
MH  - Family
MH  - Forensic Genetics/economics/*ethics/*legislation & jurisprudence
MH  - Genetic Counseling
MH  - Heart Diseases/*genetics
MH  - Humans
EDAT- 2009/10/30 06:00
MHDA- 2010/07/07 06:00
CRDT- 2009/10/30 06:00
PHST- 2009/10/30 06:00 [entrez]
PHST- 2009/10/30 06:00 [pubmed]
PHST- 2010/07/07 06:00 [medline]
AID - CGE1293 [pii]
AID - 10.1111/j.1399-0004.2009.01293.x [doi]
PST - ppublish
SO  - Clin Genet. 2010 Mar;77(3):287-92. doi: 10.1111/j.1399-0004.2009.01293.x. Epub
      2009 Oct 23.


PMID- 19861532
OWN - NLM
STAT- MEDLINE
DCOM- 20100520
LR  - 20100107
IS  - 1941-2444 (Electronic)
IS  - 0148-6071 (Linking)
VI  - 34
IP  - 1
DP  - 2010 Jan-Feb
TI  - A.S.P.E.N. recommendations for enteral nutrition: practice is the result of
      potential benefits, harms, clinical judgment, and ethical issues.
PG  - 103; author reply 104
LID - 10.1177/0148607109344626 [doi]
FAU - Cereda, Emanuele
AU  - Cereda E
FAU - Pedrolli, Carlo
AU  - Pedrolli C
LA  - eng
PT  - Comment
PT  - Letter
DEP - 20091027
PL  - United States
TA  - JPEN J Parenter Enteral Nutr
JT  - JPEN. Journal of parenteral and enteral nutrition
JID - 7804134
SB  - IM
CON - JPEN J Parenter Enteral Nutr. 2009 Mar-Apr;33(2):122-67. PMID: 19171692
MH  - *Enteral Nutrition/ethics/standards
MH  - Female
MH  - Humans
MH  - Intubation, Gastrointestinal
MH  - Myasthenia Gravis/therapy
MH  - *Practice Guidelines as Topic
MH  - *Self Care/ethics/methods
MH  - Societies, Medical
EDAT- 2009/10/29 06:00
MHDA- 2010/05/21 06:00
CRDT- 2009/10/29 06:00
PHST- 2009/10/29 06:00 [entrez]
PHST- 2009/10/29 06:00 [pubmed]
PHST- 2010/05/21 06:00 [medline]
AID - 0148607109344626 [pii]
AID - 10.1177/0148607109344626 [doi]
PST - ppublish
SO  - JPEN J Parenter Enteral Nutr. 2010 Jan-Feb;34(1):103; author reply 104. doi:
      10.1177/0148607109344626. Epub 2009 Oct 27.


PMID- 19861330
OWN - NLM
STAT- MEDLINE
DCOM- 20100308
LR  - 20220330
IS  - 1460-2350 (Electronic)
IS  - 0268-1161 (Linking)
VI  - 25
IP  - 1
DP  - 2010 Jan
TI  - An experimental protocol for fertility preservation in prepubertal boys recently 
      diagnosed with cancer: a report of acceptability and safety.
PG  - 37-41
LID - 10.1093/humrep/dep371 [doi]
AB  - BACKGROUND: Gonadal damage is a consequence of therapy for pediatric
      malignancies. Prepubertal males have no semen or mature spermatozoa, posing a
      challenge for fertility preservation. Testicular tissue cryopreservation is a
      potential option but is still experimental. We report on a pilot protocol that
      offered testicular biopsy cryopreservation to families of prepubertal boys with
      newly diagnosed malignancy. The aims were to determine the acceptability and
      safety of this procedure. METHODS: Parents of prepubertal boys with diagnoses at 
      highest risk for treatment-related gonadal damage were offered the option of
      testicular cryopreservation. Half of the biopsy was frozen for the subject's
      potential future use and the remainder used for research. Data on negative
      intraoperative and/or 7 day post-operative sequelae of testicular biopsies were
      assessed. Two to four weeks later, parents were asked to complete a questionnaire
      on factors influencing their decision to have the biopsy or not. RESULTS: Since
      January 2008, 24 boys have met the eligibility criteria but three required
      immediate treatment and were excluded. Sixteen of 21 families (76%) consented to 
      testicular biopsy, indicating the prospective acceptability of this option to
      parents of boys aged 3 months to 14 years; 14 underwent the procedure without any
      negative intra- or post-operative sequelae. Although the time at diagnosis is
      stressful, families can give thoughtful consideration to this option. Factors
      such as religion, finance, ethics and the experimental nature of cryopreservation
      did not play a major role in decision-making. CONCLUSIONS: Parents of prepubertal
      boys with cancer are willing to pursue testicular tissue cryopreservation at
      diagnosis, and testicular biopsy caused no acute adverse effects.
FAU - Ginsberg, J P
AU  - Ginsberg JP
AD  - Division of Oncology, The Children's Hospital of Philadelphia, 34th Street and
      Civic Center Blvd. Wood Building, Room 4301, Philadelphia, PA, USA.
      ginsbergji@email.chop.edu
FAU - Carlson, C A
AU  - Carlson CA
FAU - Lin, K
AU  - Lin K
FAU - Hobbie, W L
AU  - Hobbie WL
FAU - Wigo, E
AU  - Wigo E
FAU - Wu, X
AU  - Wu X
FAU - Brinster, R L
AU  - Brinster RL
FAU - Kolon, T F
AU  - Kolon TF
LA  - eng
GR  - R01 HD052728/HD/NICHD NIH HHS/United States
GR  - HD 052728/HD/NICHD NIH HHS/United States
GR  - HD 061217/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20091027
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
SB  - IM
MH  - Adolescent
MH  - Biopsy/adverse effects
MH  - Child
MH  - Child, Preschool
MH  - Cryopreservation/*methods
MH  - Humans
MH  - Infant
MH  - Infertility, Male/etiology/therapy
MH  - Male
MH  - Neoplasms/complications/drug therapy/radiotherapy
MH  - Radiation Injuries
MH  - *Reproductive Techniques, Assisted
MH  - Risk Assessment
MH  - *Testis
MH  - Tissue Preservation/*methods
PMC - PMC2794668
EDAT- 2009/10/29 06:00
MHDA- 2010/03/10 06:00
CRDT- 2009/10/29 06:00
PHST- 2009/10/29 06:00 [entrez]
PHST- 2009/10/29 06:00 [pubmed]
PHST- 2010/03/10 06:00 [medline]
AID - dep371 [pii]
AID - 10.1093/humrep/dep371 [doi]
PST - ppublish
SO  - Hum Reprod. 2010 Jan;25(1):37-41. doi: 10.1093/humrep/dep371. Epub 2009 Oct 27.


PMID- 19861328
OWN - NLM
STAT- MEDLINE
DCOM- 20100308
LR  - 20220408
IS  - 1460-2350 (Electronic)
IS  - 0268-1161 (Linking)
VI  - 25
IP  - 1
DP  - 2010 Jan
TI  - Embryo development of fresh 'versus' vitrified metaphase II oocytes after ICSI: a
      prospective randomized sibling-oocyte study.
PG  - 66-73
LID - 10.1093/humrep/dep346 [doi]
AB  - BACKGROUND: A successful oocyte cryopreservation programme is of utmost
      importance where a limited number of oocytes can be inseminated per cycle, to
      overcome legal and ethical issues related to embryo storage, for oocyte donation 
      programmes and for fertility preservation (especially for cancer patients).
      Vitrification has been recently proposed as an effective procedure for this
      purpose. METHODS: In order to validate the effectiveness of oocyte vitrification 
      a non-inferiority trial was started on sibling metaphase II (MII) oocytes. To
      demonstrate the non-inferiority based on an absolute difference of 17% in the
      fertilization rate per sibling oocyte, a minimum of 222 oocytes were required.
      After oocyte denudation, MII oocytes with normal morphology were randomly
      allocated to fresh ICSI insemination or to vitrification procedure. If pregnancy 
      was not obtained a subsequent ICSI cycle was performed with warmed oocytes of the
      same cohort. In both groups, three oocytes were inseminated per cycle by ICSI
      procedure. Primary end-points were fertilization rates calculated per warmed and 
      per injected oocytes. Secondary end-points were zygote and embryo morphology.
      RESULTS: A total of 244 oocytes were involved in this study. Of the 120 fresh
      sibling oocytes inseminated, 100 were fertilized (83.3%). Survival rate of
      sibling vitrified oocytes was 96.8% (120/124 oocytes). Fertilization rate after
      ICSI was 76.6% (95/124) per warmed oocyte and 79.2% (95/120) per
      survived/inseminated oocyte. No statistical difference in fertilization rates was
      observed between the two groups when calculated per sibling oocytes (absolute
      difference -6.73%; OR: 0.65; 95% CI = 0.33-1.29; P = 0.20) and per inseminated
      oocyte (absolute difference -4.17%; OR: 0.76; 95% CI = 0.37-1.53; P = 0.50).
      Embryo development was also similar in both treatment groups up till Day 2. The
      percentage of excellent quality embryos was 52.0% (52/100) in the fresh group and
      51.6% (49/95) in the vitrification group (absolute difference -0.43%; OR: 0.98;
      95% CI = 0.53-1.79; P = 0.9). The mean age of the 40 patients included in this
      study was 35.5 +/- 4.8 years (range 26-42). Fifteen clinical pregnancies were
      obtained in the vitrification cycles of 39 embryo transfers performed (37.5% per 
      cycle, 38.5% per embryo transfer), with an implantation rate of 20.2% (19/94).
      Three spontaneous miscarriages occurred (20%). Twelve pregnancies are ongoing
      (30.0% per cycle, 30.8% per embryo transfer) beyond 12 weeks of gestation.
      CONCLUSIONS: Our results indicate that oocyte vitrification procedure followed by
      ICSI is not inferior to fresh insemination procedure, with regard to
      fertilization and embryo developmental rates. Moreover, ongoing clinical
      pregnancy is compatible with this procedure, even with a restricted number of
      oocytes available for insemination. The promising clinical results obtained, in a
      population of infertile patients, need to be confirmed on a larger scale.
      CLINICAL TRIALS REGISTRATION NUMBER: iSRCTN60158641.
FAU - Rienzi, Laura
AU  - Rienzi L
AD  - G.E.N.E.R.A. Centre for Reproductive Medicine, Clinica Valle Giulia, via de
      Notaris 2B, Rome, Italy. rienzi@generaroma.it
FAU - Romano, Stefania
AU  - Romano S
FAU - Albricci, Laura
AU  - Albricci L
FAU - Maggiulli, Roberta
AU  - Maggiulli R
FAU - Capalbo, Antonio
AU  - Capalbo A
FAU - Baroni, Elena
AU  - Baroni E
FAU - Colamaria, Silvia
AU  - Colamaria S
FAU - Sapienza, Fabio
AU  - Sapienza F
FAU - Ubaldi, Filippo
AU  - Ubaldi F
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20091027
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
SB  - IM
MH  - Adult
MH  - Cell Culture Techniques
MH  - *Cryopreservation
MH  - Embryo Transfer
MH  - *Embryonic Development
MH  - Female
MH  - Fertilization
MH  - Humans
MH  - *Metaphase
MH  - Oocytes/*cytology/growth & development
MH  - Pregnancy
MH  - Pregnancy Rate
MH  - *Sperm Injections, Intracytoplasmic
PMC - PMC2794665
EDAT- 2009/10/29 06:00
MHDA- 2010/03/10 06:00
CRDT- 2009/10/29 06:00
PHST- 2009/10/29 06:00 [entrez]
PHST- 2009/10/29 06:00 [pubmed]
PHST- 2010/03/10 06:00 [medline]
AID - dep346 [pii]
AID - 10.1093/humrep/dep346 [doi]
PST - ppublish
SO  - Hum Reprod. 2010 Jan;25(1):66-73. doi: 10.1093/humrep/dep346. Epub 2009 Oct 27.


PMID- 19861315
OWN - NLM
STAT- MEDLINE
DCOM- 20100603
LR  - 20220309
IS  - 1460-2385 (Electronic)
IS  - 0931-0509 (Linking)
VI  - 25
IP  - 3
DP  - 2010 Mar
TI  - The first Chinese Pierson syndrome with novel mutations in LAMB2.
PG  - 776-8
LID - 10.1093/ndt/gfp563 [doi]
AB  - BACKGROUND: Pierson syndrome is typically manifested with congenital nephrotic
      syndrome (CNS) and peculiar ocular changes. LAMB2 was the causative gene.
      METHODS: A 3.25-year-old girl presenting with childhood-onset heavy proteinuria, 
      bilateral myosis and nystagmus was detected on mutations of LAMB2 gene by PCR
      direct sequencing. RESULTS: Two novel mutations were identified, C757fsX767 and
      P1413fsX1451, which predicted truncated proteins and were confirmed in the
      paternal and maternal origins, respectively. CONCLUSIONS: This is the first
      Chinese case of Pierson syndrome diagnosed by clinical manifestations and LAMB2
      gene mutations. The phenotype may be different in different ethics.
FAU - Zhao, Dan
AU  - Zhao D
AD  - Department of Pediatrics, Peking University First Hospital, Beijing 100034, PR
      China.
FAU - Ding, Jie
AU  - Ding J
FAU - Wang, Fang
AU  - Wang F
FAU - Fan, Qingfeng
AU  - Fan Q
FAU - Guan, Na
AU  - Guan N
FAU - Wang, Suxia
AU  - Wang S
FAU - Zhang, Yan
AU  - Zhang Y
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091026
PL  - England
TA  - Nephrol Dial Transplant
JT  - Nephrology, dialysis, transplantation : official publication of the European
      Dialysis and Transplant Association - European Renal Association
JID - 8706402
RN  - 0 (Laminin)
RN  - 124148-86-3 (laminin beta2)
SB  - IM
MH  - Child, Preschool
MH  - China
MH  - Eye Abnormalities/ethnology/*genetics
MH  - Female
MH  - Gene Deletion
MH  - Humans
MH  - Kidney Diseases/*congenital/ethnology/*genetics
MH  - Laminin/*genetics
MH  - Mutation/*genetics
MH  - Nystagmus, Congenital/ethnology/*genetics
MH  - Proteinuria/genetics
MH  - Syndrome
EDAT- 2009/10/29 06:00
MHDA- 2010/06/04 06:00
CRDT- 2009/10/29 06:00
PHST- 2009/10/29 06:00 [entrez]
PHST- 2009/10/29 06:00 [pubmed]
PHST- 2010/06/04 06:00 [medline]
AID - gfp563 [pii]
AID - 10.1093/ndt/gfp563 [doi]
PST - ppublish
SO  - Nephrol Dial Transplant. 2010 Mar;25(3):776-8. doi: 10.1093/ndt/gfp563. Epub 2009
      Oct 26.


PMID- 19859816
OWN - NLM
STAT- MEDLINE
DCOM- 20100420
LR  - 20220801
IS  - 1573-7284 (Electronic)
IS  - 0393-2990 (Linking)
VI  - 25
IP  - 1
DP  - 2010
TI  - Mathematical modeling and the epidemiological research process.
PG  - 13-9
LID - 10.1007/s10654-009-9397-9 [doi]
AB  - The authors of this paper advocate for the expanded use of mathematical models in
      epidemiology and provide an overview of the principles of mathematical modeling. 
      Mathematical models can be used throughout the epidemiological research process. 
      Initially they may help to refine study questions by visually expressing complex 
      systems, directing literature searches, and identifying sensitive variables. In
      the study design phase, models can be used to test sampling strategies, to
      estimate sample size and power, and to predict outcomes for studies impractical
      due to time or ethical considerations. Once data are collected, models can assist
      in the interpretation of results, the exploration of causal pathways, and the
      combined analysis of data from multiple sources. Finally, models are commonly
      used in the process of applying research findings to public health practice by
      estimating population risk, predicting the effects of interventions, and
      contributing to the evaluation of ongoing programs. Mathematical modeling has the
      potential to make significant contributions to the field of epidemiology by
      enhancing the research process, serving as a tool for communicating findings to
      policymakers, and fostering interdisciplinary collaboration.
FAU - Chubb, Mikayla C
AU  - Chubb MC
AD  - Department of Global and Community Health, George Mason University, 4400
      University Drive MS 5B7, Fairfax, VA 22030-4444, USA.
FAU - Jacobsen, Kathryn H
AU  - Jacobsen KH
LA  - eng
PT  - Journal Article
DEP - 20091027
PL  - Netherlands
TA  - Eur J Epidemiol
JT  - European journal of epidemiology
JID - 8508062
SB  - IM
MH  - Epidemiologic Research Design
MH  - *Epidemiologic Studies
MH  - Humans
MH  - *Models, Statistical
MH  - Public Health
EDAT- 2009/10/28 06:00
MHDA- 2010/04/21 06:00
CRDT- 2009/10/28 06:00
PHST- 2009/05/15 00:00 [received]
PHST- 2009/10/07 00:00 [accepted]
PHST- 2009/10/28 06:00 [entrez]
PHST- 2009/10/28 06:00 [pubmed]
PHST- 2010/04/21 06:00 [medline]
AID - 10.1007/s10654-009-9397-9 [doi]
PST - ppublish
SO  - Eur J Epidemiol. 2010;25(1):13-9. doi: 10.1007/s10654-009-9397-9. Epub 2009 Oct
      27.


PMID- 19859775
OWN - NLM
STAT- MEDLINE
DCOM- 20100330
LR  - 20220310
IS  - 1496-8975 (Electronic)
IS  - 0832-610X (Linking)
VI  - 57
IP  - 1
DP  - 2010 Jan
TI  - Ultrasound assessment of the vertebral level of the palpated intercristal
      (Tuffier's) line.
PG  - 46-9
LID - 10.1007/s12630-009-9208-5 [doi]
AB  - PURPOSE: Identification of a particular vertebral level by clinical landmark
      palpation is inaccurate. This study uses ultrasound imaging to assess the
      vertebral level at which the palpated intercristal line occurs in subjects
      clinically positioned to receive a neuraxial technique. METHODS: Following
      Research Ethics Board approval and informed written consent, 114 adult subjects
      were seated in the position used clinically for placement of a neuraxial block. A
      single investigator marked the skin where the palpated intercristal line crossed 
      the spinous processes. A 2-5 MHz curved ultrasound probe in paramedian
      orientation was advanced cephalad from the sacrum, counting the
      ultrasound-visualized intervertebral levels until the skin marking was
      encountered. The weight, height, waist circumference, body mass index, and age of
      the volunteers were recorded. These physical characteristics and relationship to 
      the ultrasound-measured palpated intercristal line were assessed using the Chi
      square and Tukey Honestly Statistically Different tests. RESULTS: Using
      ultrasound, the palpated intercristal line was identified at the L3-4 interspace 
      in 83 (73%), at L4-5 in 16 (14%), and at L2-3 in 15 (13%) of volunteers,
      respectively. Those with a palpated intercristal line at L2-3 were taller (mean
      difference 7.8 cm, 95% confidence interval 2.6-13.0 cm) and more likely to be
      male (22% vs 6%; P = 0.016) than those imaged with a palpated intercristal line
      at L3-4 or below. CONCLUSIONS: According to ultrasound, the palpated intercristal
      line falls at the L3-4 interspace, or below, in the majority of subjects
      positioned for neuraxial block in the sitting position. A palpated intercristal
      line at L2-3 was more likely in tall and male individuals.
FAU - Pysyk, Christopher L
AU  - Pysyk CL
AD  - Department of Anesthesiology, The Ottawa Hospital, University of Ottawa, Civic
      Campus, Ottawa, ON, K1Y 4E9, Canada. cpysyk@shaw.ca
FAU - Persaud, Desiree
AU  - Persaud D
FAU - Bryson, Gregory L
AU  - Bryson GL
FAU - Lui, Anne
AU  - Lui A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091027
PL  - United States
TA  - Can J Anaesth
JT  - Canadian journal of anaesthesia = Journal canadien d'anesthesie
JID - 8701709
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Body Height
MH  - Chi-Square Distribution
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Lumbar Vertebrae/*anatomy & histology/diagnostic imaging
MH  - Male
MH  - Middle Aged
MH  - Nerve Block/methods
MH  - Sex Factors
MH  - Spinal Cord/*anatomy & histology/diagnostic imaging
MH  - Ultrasonography
MH  - Young Adult
EDAT- 2009/10/28 06:00
MHDA- 2010/03/31 06:00
CRDT- 2009/10/28 06:00
PHST- 2009/03/30 00:00 [received]
PHST- 2009/10/13 00:00 [accepted]
PHST- 2009/10/28 06:00 [entrez]
PHST- 2009/10/28 06:00 [pubmed]
PHST- 2010/03/31 06:00 [medline]
AID - 10.1007/s12630-009-9208-5 [doi]
PST - ppublish
SO  - Can J Anaesth. 2010 Jan;57(1):46-9. doi: 10.1007/s12630-009-9208-5. Epub 2009 Oct
      27.


PMID- 19859691
OWN - NLM
STAT- MEDLINE
DCOM- 20100506
LR  - 20211020
IS  - 1432-0428 (Electronic)
IS  - 0012-186X (Linking)
VI  - 53
IP  - 1
DP  - 2010 Jan
TI  - Diabetes treatment with insulin glargine and risk of malignancy: methodological
      pitfalls and ethical issues.
PG  - 204-5
LID - 10.1007/s00125-009-1572-8 [doi]
FAU - Simon, D
AU  - Simon D
LA  - eng
PT  - Comment
PT  - Letter
PT  - Research Support, Non-U.S. Gov't
DEP - 20091027
PL  - Germany
TA  - Diabetologia
JT  - Diabetologia
JID - 0006777
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
RN  - 0 (Insulin, Long-Acting)
RN  - 2ZM8CX04RZ (Insulin Glargine)
SB  - IM
CON - Diabetologia. 2009 Sep;52(9):1732-44. PMID: 19565214
MH  - Diabetes Mellitus/*drug therapy
MH  - Dose-Response Relationship, Drug
MH  - *Ethics, Medical
MH  - Humans
MH  - Hypoglycemic Agents/*adverse effects/*therapeutic use
MH  - Insulin/adverse effects/*analogs & derivatives/therapeutic use
MH  - Insulin Glargine
MH  - Insulin, Long-Acting
MH  - Neoplasms/*chemically induced/epidemiology
MH  - Risk Factors
MH  - Safety
PMC - PMC2789934
EDAT- 2009/10/28 06:00
MHDA- 2010/05/07 06:00
CRDT- 2009/10/28 06:00
PHST- 2009/09/04 00:00 [received]
PHST- 2009/09/22 00:00 [accepted]
PHST- 2009/10/28 06:00 [entrez]
PHST- 2009/10/28 06:00 [pubmed]
PHST- 2010/05/07 06:00 [medline]
AID - 10.1007/s00125-009-1572-8 [doi]
PST - ppublish
SO  - Diabetologia. 2010 Jan;53(1):204-5. doi: 10.1007/s00125-009-1572-8. Epub 2009 Oct
      27.


PMID- 19857984
OWN - NLM
STAT- MEDLINE
DCOM- 20100622
LR  - 20100203
IS  - 1887-1364 (Electronic)
IS  - 1134-282X (Linking)
VI  - 25
IP  - 1
DP  - 2010 Jan-Feb
TI  - [The ethics review process in the Seventh Framework Programme of the European
      Commission].
PG  - 48-51
LID - 10.1016/j.cali.2009.07.006 [doi]
AB  - The Seventh Framework Programme of the European Commission (EC) is one of the
      most important instruments for public funding of research and technological
      development. Besides the scientific assessment of each proposal, the ethical
      issues raised in them are evaluated in accordance with the current European
      legislation and the ethical principles laid down in the international
      declarations supported by Member States. Such ethical review is organized by the 
      "Governance and Ethics" Unit (Directorate-General for Research), although it is
      done by professionals from different sectors and backgrounds who register
      themselves voluntary in a database.
CI  - Copyright 2009 SECA. Published by Elsevier Espana. All rights reserved.
FAU - Perez Blanco, V
AU  - Perez Blanco V
AD  - Direccion General de Investigacion, Comision Europea, Bruselas, Belgica.
      vperez@sescam.jccm.es
FAU - Hirsch, F
AU  - Hirsch F
FAU - Gonzalez Pantaleon, P
AU  - Gonzalez Pantaleon P
FAU - Kritikos, M
AU  - Kritikos M
FAU - Karatzas, I
AU  - Karatzas I
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - El proceso de evaluacion etica en el Septimo Programa Marco de la Comision
      Europea.
DEP - 20091025
PL  - Spain
TA  - Rev Calid Asist
JT  - Revista de calidad asistencial : organo de la Sociedad Espanola de Calidad
      Asistencial
JID - 9601664
SB  - IM
MH  - *Ethical Review
MH  - *Ethics, Research
MH  - European Union
EDAT- 2009/10/28 06:00
MHDA- 2010/06/23 06:00
CRDT- 2009/10/28 06:00
PHST- 2009/03/17 00:00 [received]
PHST- 2009/07/20 00:00 [revised]
PHST- 2009/07/27 00:00 [accepted]
PHST- 2009/10/28 06:00 [entrez]
PHST- 2009/10/28 06:00 [pubmed]
PHST- 2010/06/23 06:00 [medline]
AID - S1134-282X(09)00041-4 [pii]
AID - 10.1016/j.cali.2009.07.006 [doi]
PST - ppublish
SO  - Rev Calid Asist. 2010 Jan-Feb;25(1):48-51. doi: 10.1016/j.cali.2009.07.006. Epub 
      2009 Oct 25.


PMID- 19857142
OWN - NLM
STAT- MEDLINE
DCOM- 20100217
LR  - 20101118
IS  - 1064-5462 (Print)
IS  - 1064-5462 (Linking)
VI  - 16
IP  - 1
DP  - 2010 Winter
TI  - Living technology: exploiting life's principles in technology.
PG  - 89-97
LID - 10.1162/artl.2009.16.1.16103 [doi]
AB  - The concept of living technology-that is, technology that is based on the
      powerful core features of life-is explained and illustrated with examples from
      artificial life software, reconfigurable and evolvable hardware, autonomously
      self-reproducing robots, chemical protocells, and hybrid electronic-chemical
      systems. We define primary (secondary) living technology according as key
      material components and core systems are not (are) derived from living organisms.
      Primary living technology is currently emerging, distinctive, and potentially
      powerful, motivating this review. We trace living technology's connections with
      artificial life (soft, hard, and wet), synthetic biology (top-down and
      bottom-up), and the convergence of nano-, bio-, information, and cognitive (NBIC)
      technologies. We end with a brief look at the social and ethical questions
      generated by the prospect of living technology.
FAU - Bedau, Mark A
AU  - Bedau MA
AD  - University of Southern Denmark, Odense, Denmark, USA. mab@reed.edu
FAU - McCaskill, John S
AU  - McCaskill JS
FAU - Packard, Norman H
AU  - Packard NH
FAU - Rasmussen, Steen
AU  - Rasmussen S
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Artif Life
JT  - Artificial life
JID - 9433814
SB  - IM
MH  - *Biological Evolution
MH  - Computer Simulation
MH  - *Models, Biological
MH  - Software
RF  - 32
EDAT- 2009/10/28 06:00
MHDA- 2010/02/18 06:00
CRDT- 2009/10/28 06:00
PHST- 2009/10/28 06:00 [entrez]
PHST- 2009/10/28 06:00 [pubmed]
PHST- 2010/02/18 06:00 [medline]
AID - 10.1162/artl.2009.16.1.16103 [doi]
PST - ppublish
SO  - Artif Life. 2010 Winter;16(1):89-97. doi: 10.1162/artl.2009.16.1.16103.


PMID- 19855280
OWN - NLM
STAT- MEDLINE
DCOM- 20100311
LR  - 20211020
IS  - 1531-7013 (Electronic)
IS  - 1087-2418 (Linking)
VI  - 15
IP  - 1
DP  - 2010 Feb
TI  - Inducible pluripotent stem cells: not quite ready for prime time?
PG  - 61-7
LID - 10.1097/MOT.0b013e3283337196 [doi]
AB  - PURPOSE OF REVIEW: Inducible pluripotent stem (iPS) cells derived from somatic
      cells represent a novel renewable source of tissue precursors. The potential of
      iPS cells is considered to be at least equivalent to that of human embryonic stem
      cells, facilitating the treatment or cure of diseases such as diabetes mellitus, 
      spinal cord injuries, cardiovascular disease, and neurodegenerative diseases, but
      with the potential added benefit of evading the adaptive immune response that
      otherwise limits allogeneic cell-based therapies. This review discusses recent
      advances in pluripotency induction and the use of iPS cells to produce
      differentiated cells, while highlighting roadblocks to the widespread use of this
      technology in the clinical arena. RECENT FINDINGS: Whereas ethical and safety
      issues surrounding the use of human embryonic stem cells for the treatment of
      disease continue to be debated, use of iPS cells may be viewed as a more widely
      acceptable compromise. Since the first descriptions of inducible pluripotency
      from somatic cells, multiple laboratories have collectively made tremendous
      strides both in developing alternative, more clinically acceptable, induction
      strategies and in demonstrating the proof-of-principle that iPS cells can be
      differentiated into a variety of cell types to reverse mouse models of human
      disease. SUMMARY: Although the prospect of using patient-specific iPS cells has
      much appeal from an ethical and immunologic perspective, the limitations of the
      technology from the standpoint of reprogramming efficiency and therapeutic safety
      necessitate much more in-depth research before the initiation of human clinical
      trials.
FAU - Robbins, Reiesha D
AU  - Robbins RD
AD  - Department of Pharmacology, University of Virginia, Charlottesville, Virginia,
      USA.
FAU - Prasain, Nutan
AU  - Prasain N
FAU - Maier, Bernhard F
AU  - Maier BF
FAU - Yoder, Mervin C
AU  - Yoder MC
FAU - Mirmira, Raghavendra G
AU  - Mirmira RG
LA  - eng
GR  - R01 DK060581-07/DK/NIDDK NIH HHS/United States
GR  - P30 DK067629/DK/NIDDK NIH HHS/United States
GR  - R01 DK060581/DK/NIDDK NIH HHS/United States
GR  - R01 AI080759/AI/NIAID NIH HHS/United States
GR  - F31 DK079420/DK/NIDDK NIH HHS/United States
GR  - R01 DK060581-08/DK/NIDDK NIH HHS/United States
GR  - R01 DK60581/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United States
TA  - Curr Opin Organ Transplant
JT  - Current opinion in organ transplantation
JID - 9717388
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - *Cell Differentiation/genetics
MH  - Disease Models, Animal
MH  - Epigenesis, Genetic
MH  - Gene Expression Regulation, Developmental
MH  - Humans
MH  - Induced Pluripotent Stem Cells/metabolism/*transplantation
MH  - Mice
MH  - *Regeneration/genetics
MH  - *Stem Cell Transplantation
MH  - *Tissue Engineering
MH  - Transcription Factors/genetics/metabolism
RF  - 73
PMC - PMC3617582
MID - NIHMS180976
EDAT- 2009/10/27 06:00
MHDA- 2010/03/12 06:00
CRDT- 2009/10/27 06:00
PHST- 2009/10/27 06:00 [entrez]
PHST- 2009/10/27 06:00 [pubmed]
PHST- 2010/03/12 06:00 [medline]
AID - 10.1097/MOT.0b013e3283337196 [doi]
PST - ppublish
SO  - Curr Opin Organ Transplant. 2010 Feb;15(1):61-7. doi:
      10.1097/MOT.0b013e3283337196.


PMID- 19854996
OWN - NLM
STAT- MEDLINE
DCOM- 20100726
LR  - 20100420
IS  - 1525-3163 (Electronic)
IS  - 0021-8812 (Linking)
VI  - 88
IP  - 13 Suppl
DP  - 2010 Apr
TI  - Engaging science in a climate of values: tools for animal scientists tasked with 
      addressing ethical problems.
PG  - E75-81
LID - 10.2527/jas.2009-2353 [doi]
AB  - In the United States, escalating concerns about current farm animal science and
      production methods have resulted not only in increased food animal protection
      policies, but also in animal welfare legislation. Animal scientists and industry 
      leaders are apprehensive that such policies may be driven primarily by emotion
      and a lack of scientific understanding, and thus may have unforeseen
      consequences. However, decisions about animal care, and particularly animal
      welfare, cannot be made solely on the basis of science because the potential
      effects on producers, animals, and concerned citizens and the implications for
      the environment and on food prices must also be considered. Balancing the
      interests and values of all stakeholders in regard to animal welfare problems has
      presented a considerable challenge. Ethical accounting processes, such as the
      Ethical Matrix and the ethics assessment process by Campbell, offer models to
      combine socioethical concerns with relevant factual information, thereby
      facilitating decision making that is ethically responsible and that offers viable
      solutions. A case study is used to illustrate application of the ethics
      assessment process by Campbell that includes identification of the ethical
      problems, the embedded values, the relevant facts, and moral tests that can be
      applied. Awareness of these emerging ways of examining ethics that offer real
      solutions to conflicts of interests and not merely "one size fits all" answers
      should be an asset to animal and poultry scientists.
FAU - Croney, C C
AU  - Croney CC
AD  - Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The
      Ohio State University, Columbus, OH 43210, USA. croney.1@osu.edu
FAU - Anthony, R
AU  - Anthony R
LA  - eng
PT  - Journal Article
DEP - 20091023
PL  - United States
TA  - J Anim Sci
JT  - Journal of animal science
JID - 8003002
SB  - IM
MH  - Animal Husbandry/*ethics
MH  - Animal Welfare/ethics
MH  - Animals
MH  - *Ethics, Research
MH  - Models, Theoretical
MH  - Social Values
MH  - United States
EDAT- 2009/10/27 06:00
MHDA- 2010/07/27 06:00
CRDT- 2009/10/27 06:00
PHST- 2009/10/27 06:00 [entrez]
PHST- 2009/10/27 06:00 [pubmed]
PHST- 2010/07/27 06:00 [medline]
AID - jas.2009-2353 [pii]
AID - 10.2527/jas.2009-2353 [doi]
PST - ppublish
SO  - J Anim Sci. 2010 Apr;88(13 Suppl):E75-81. doi: 10.2527/jas.2009-2353. Epub 2009
      Oct 23.


PMID- 19853672
OWN - NLM
STAT- MEDLINE
DCOM- 20100518
LR  - 20100215
IS  - 1743-9159 (Electronic)
IS  - 1743-9159 (Linking)
VI  - 8
IP  - 1
DP  - 2010
TI  - Traditional polypropylene and lightweight meshes in totally extraperitoneal
      inguinal herniorrhaphy.
PG  - 44-7
LID - 10.1016/j.ijsu.2009.08.014 [doi]
AB  - BACKGROUND: Placement of a prosthetic mesh is integral to successful totally
      extraperitoneal (TEP) herniorrhaphy. Available meshes have supported the surgical
      efforts well but search for an ideal mesh continues. Post-herniorrhaphy pain is
      an index of patient reported outcomes (PRO). The pain is attributable to balloon 
      dissection, cautery, sutures, tackers and prosthesis. Reducing polypropylene
      content of the mesh is associated with attenuated inflammatory response by the
      host and improved compliance and comfort. We report the difference in PROs in TEP
      herniorrhaphy with either heavy polypropylene (PPM) or light weight mesh (LWM)
      being used for the repair. PATIENTS AND METHODS: From June 2004 to December 2005,
      consecutive candidates for TEP herniorrhaphy were enrolled for this prospective
      study with an informed consent and compliance to Ethics guidelines. They were
      operated under general anesthesia (GA) on a day care basis using either PPM or
      LWM meshes as per the patient's choice. Operative and postoperative PRO were
      statistically analyzed by an independent doctor using the Microsoft Office Excel 
      2003. RESULTS: One hundred fourteen (84 PPMs and 30 LWMs) TEP herniorrhaphies
      were performed under GA on 57 male patients without any exclusion, on a day care 
      basis. There was no technical difficulty, operative complications, conversion or 
      prolonged hospital stay in either group. Patients of LWM reported better outcome 
      in regards to pain, NSAID usage, seroma and recurrence. All patients of LWM
      reported an earlier return to activity. CONCLUSION: Light weight meshes result in
      comparatively better "patient reported outcomes" in TEP inguinal herniorrhaphy as
      compared to heavy polypropylene meshes.
CI  - Copyright 2009 Surgical Associates Ltd. Published by Elsevier Ltd. All rights
      reserved.
FAU - Agarwal, Brij B
AU  - Agarwal BB
AD  - Dr. Agarwal's Surgery & Yoga, F-81&82, Street 4, Virender Nagar, New Delhi
      110058, India. endosurgeon@gmail.com
FAU - Agarwal, Krishna A
AU  - Agarwal KA
FAU - Sahu, Tapish
AU  - Sahu T
FAU - Mahajan, Krishan C
AU  - Mahajan KC
LA  - eng
PT  - Journal Article
DEP - 20091022
PL  - England
TA  - Int J Surg
JT  - International journal of surgery (London, England)
JID - 101228232
RN  - 0 (Polypropylenes)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Hernia, Inguinal/*surgery
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pain Measurement
MH  - Pain, Postoperative
MH  - Polypropylenes
MH  - Postoperative Complications
MH  - Prospective Studies
MH  - Recurrence
MH  - *Surgical Mesh
MH  - Treatment Outcome
EDAT- 2009/10/27 06:00
MHDA- 2010/05/19 06:00
CRDT- 2009/10/27 06:00
PHST- 2009/07/19 00:00 [received]
PHST- 2009/08/10 00:00 [accepted]
PHST- 2009/10/27 06:00 [entrez]
PHST- 2009/10/27 06:00 [pubmed]
PHST- 2010/05/19 06:00 [medline]
AID - S1743-9191(09)00149-6 [pii]
AID - 10.1016/j.ijsu.2009.08.014 [doi]
PST - ppublish
SO  - Int J Surg. 2010;8(1):44-7. doi: 10.1016/j.ijsu.2009.08.014. Epub 2009 Oct 22.


PMID- 19853341
OWN - NLM
STAT- MEDLINE
DCOM- 20100218
LR  - 20100119
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 70
IP  - 2
DP  - 2010 Jan
TI  - "Broad" consent, exceptions to consent and the question of using biological
      samples for research purposes different from the initial collection purpose.
PG  - 217-20
LID - 10.1016/j.socscimed.2009.10.004 [doi]
AB  - An important ethical issue regarding biological samples stored in biobanks is
      unforeseen future sample use, when no or limited subject consent is obtained.
      Biobanks of biological samples have significant future research potential, but
      may cause conflicts of interest regarding the consent obtained. Indeed, ethics,
      deontology, and jurisprudence generally advise that consent must be specific and 
      circumstantiated. However, it is not possible to foresee all of the future
      circumstances in which the samples might be useful, nor is it possible to
      re-contact all subjects in order to gain consent for a new use. The main
      arguments for the use of "broad" consent are presented with a brief discussion of
      the conditions where it may be legitimate not to obtain consent. Particular
      attention is given to the expressed positions of national and international
      bioethics bodies.
CI  - Copyright 2009 Elsevier Ltd. All rights reserved.
FAU - Petrini, Carlo
AU  - Petrini C
AD  - Bioethics Unit-Office of the President, Istituto Superiore di Sanita, Roma,
      Italy. carlo.petrini@iss.it
LA  - eng
PT  - Journal Article
DEP - 20091021
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Bioethical Issues
MH  - Biological Specimen Banks/*ethics
MH  - Biomedical Research/*ethics
MH  - Conflict of Interest
MH  - Europe
MH  - Humans
MH  - Informed Consent/*ethics/legislation & jurisprudence
MH  - *Tissue Donors
EDAT- 2009/10/27 06:00
MHDA- 2010/02/19 06:00
CRDT- 2009/10/27 06:00
PHST- 2009/03/29 00:00 [received]
PHST- 2009/10/27 06:00 [entrez]
PHST- 2009/10/27 06:00 [pubmed]
PHST- 2010/02/19 06:00 [medline]
AID - S0277-9536(09)00666-2 [pii]
AID - 10.1016/j.socscimed.2009.10.004 [doi]
PST - ppublish
SO  - Soc Sci Med. 2010 Jan;70(2):217-20. doi: 10.1016/j.socscimed.2009.10.004. Epub
      2009 Oct 21.


PMID- 19851850
OWN - NLM
STAT- MEDLINE
DCOM- 20100603
LR  - 20211020
IS  - 1573-3599 (Electronic)
IS  - 1059-7700 (Linking)
VI  - 19
IP  - 2
DP  - 2010 Apr
TI  - Genetic counselors' perceived responsibilities regarding reproductive issues for 
      patients at risk for Huntington disease.
PG  - 131-47
LID - 10.1007/s10897-009-9265-5 [doi]
AB  - Research indicates that health care professionals' attitudes may affect patients'
      decisions regarding prenatal Huntington Disease testing, but few studies have
      sampled genetic counselors. In this qualitative study, genetic counselors
      described their experiences counseling individuals at risk for HD regarding
      reproductive decision-making. Five major research questions were investigated: 1)
      What are genetic counselor responsibilities? 2) What issues arise for patients
      and counselors? 3) How do counselors reconcile prenatal testing with
      presymptomatic testing? 4) To what extent are counselors' initial expectations of
      at-risk patients' beliefs and behaviors met? and 5) What advice would counselors 
      offer to novice practitioners about working with this patient population? Fifteen
      genetic counselors experienced in counseling individuals at risk for HD
      participated in a semi-structured phone interview that yielded several themes.
      For example, participants identified their primary responsibility as information 
      provision; less prevalent were psychosocial support and facilitating decision
      making. The most common ethical challenge was testing prenatally for HD which
      also results in presymptomatic testing of minors. Participants were divided about
      how directive to be in response to this ethical issue and about termination of a 
      gene positive pregnancy.
FAU - Hines, Karrie A
AU  - Hines KA
AD  - Department of Obstetrics and Gynecology, Indiana University School of Medicine,
      Indianapolis, IN, USA.
FAU - Veach, Patricia McCarthy
AU  - Veach PM
FAU - LeRoy, Bonnie S
AU  - LeRoy BS
LA  - eng
PT  - Journal Article
DEP - 20091023
PL  - United States
TA  - J Genet Couns
JT  - Journal of genetic counseling
JID - 9206865
SB  - IM
MH  - Adult
MH  - Decision Making
MH  - Female
MH  - *Genetic Counseling
MH  - Genetic Testing
MH  - Humans
MH  - Huntington Disease/*physiopathology
MH  - Pregnancy
MH  - *Reproduction
MH  - Risk Factors
EDAT- 2009/10/24 06:00
MHDA- 2010/06/04 06:00
CRDT- 2009/10/24 06:00
PHST- 2009/05/19 00:00 [received]
PHST- 2009/10/01 00:00 [accepted]
PHST- 2009/10/24 06:00 [entrez]
PHST- 2009/10/24 06:00 [pubmed]
PHST- 2010/06/04 06:00 [medline]
AID - 10.1007/s10897-009-9265-5 [doi]
PST - ppublish
SO  - J Genet Couns. 2010 Apr;19(2):131-47. doi: 10.1007/s10897-009-9265-5. Epub 2009
      Oct 23.


PMID- 19851745
OWN - NLM
STAT- MEDLINE
DCOM- 20100408
LR  - 20211020
IS  - 1433-0407 (Electronic)
IS  - 0028-2804 (Linking)
VI  - 81
IP  - 1
DP  - 2010 Jan
TI  - [Options, limits and ethics of pharmacological neuroenhancement].
PG  - 66-74
LID - 10.1007/s00115-009-2858-2 [doi]
AB  - Pharmacological neuroenhancement is an attempt to increase cognitive performance 
      in healthy humans. Learning and memory, attention and vigilance or mood and
      social interaction are targeted by a modulation of brain plasticity. Firstly, an 
      analysis of the current state of research shows that, until now, clinical trials 
      of neuroenhancing drugs have demonstrated only limited efficacy and long-term
      side effects remain largely unexplored. Secondly, we argue that, from an ethical 
      perspective, neuroenhancement differs from socially mediated methods of learning.
      Pharmacological neuroenhancement is based on notions of efficacy and control that
      threaten to undermine other important aspects of mental capacities.
FAU - Normann, C
AU  - Normann C
AD  - Abteilung Psychiatrie und Psychotherapie, Universitatsklinikum, Hauptstrasse 5,
      79104 Freiburg. claus.normann@uniklinik-freiburg.de
FAU - Boldt, J
AU  - Boldt J
FAU - Maio, G
AU  - Maio G
FAU - Berger, M
AU  - Berger M
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Moglichkeiten und Grenzen des pharmakologischen Neuroenhancements.
PL  - Germany
TA  - Nervenarzt
JT  - Der Nervenarzt
JID - 0400773
RN  - 0 (Central Nervous System Stimulants)
SB  - IM
MH  - Arousal/*drug effects
MH  - Biomedical Enhancement/*ethics/*methods
MH  - Central Nervous System Stimulants/*administration & dosage/*adverse effects
MH  - Cognition/*drug effects
MH  - Germany
MH  - Humans
RF  - 64
EDAT- 2009/10/24 06:00
MHDA- 2010/04/09 06:00
CRDT- 2009/10/24 06:00
PHST- 2009/10/24 06:00 [entrez]
PHST- 2009/10/24 06:00 [pubmed]
PHST- 2010/04/09 06:00 [medline]
AID - 10.1007/s00115-009-2858-2 [doi]
PST - ppublish
SO  - Nervenarzt. 2010 Jan;81(1):66-74. doi: 10.1007/s00115-009-2858-2.


PMID- 19851124
OWN - NLM
STAT- MEDLINE
DCOM- 20100719
LR  - 20211028
IS  - 1540-0514 (Electronic)
IS  - 1073-2322 (Linking)
VI  - 33
IP  - 4
DP  - 2010 Apr
TI  - Early microvascular changes in sepsis and severe sepsis.
PG  - 387-91
LID - 10.1097/SHK.0b013e3181c6be04 [doi]
AB  - Efforts to improve survival from sepsis are focusing increasingly on intervention
      during the earliest stages of this disease. The importance of derangements in
      microvascular flow in patients with established sepsis is well recognized.
      However, little data are available to describe microvascular changes in early
      sepsis. After research ethics committee approval, observational data were
      collected in healthy volunteers and within 6 h of presentation in patients with
      sepsis and severe sepsis. Sidestream dark-field imaging was used to obtain video 
      images of the sublingual microcirculation. Cardiac index was measured using the
      noninvasive suprasternal Doppler method. Forty-eight patients and 16 healthy
      volunteers were recruited. Twenty-eight patients were diagnosed with sepsis and
      19 with severe sepsis. Eight patients (17%) did not survive to leave hospital.
      For small vessels (<20 microm), microvascular flow index (P < 0.05),
      heterogeneity index (P < 0.05) and the proportion of perfused vessels (P < 0.05) 
      were lower in patients with sepsis and severe sepsis compared with healthy
      volunteers. Perfused vessel density (P < 0.05) was lower in the severe sepsis
      group compared with the sepsis group. The proportion of perfused vessels (P <
      0.01) and MAP (P < 0.05) were lower in nonsurvivors compared with survivors.
      Sepsis results in derangements of microvascular flow, which can be identified in 
      the early stages of this disease. These abnormalities are more marked in the most
      severely ill patients. Further research is required to fully characterize the
      effects of sepsis on microvascular function.
FAU - Spanos, Angeliki
AU  - Spanos A
AD  - Barts & The London School of Medicine and Dentistry, Queen Mary's University of
      London, London, United Kingdom.
FAU - Jhanji, Shaman
AU  - Jhanji S
FAU - Vivian-Smith, Amanda
AU  - Vivian-Smith A
FAU - Harris, Tim
AU  - Harris T
FAU - Pearse, Rupert M
AU  - Pearse RM
LA  - eng
GR  - CS/08/08/17/DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Shock
JT  - Shock (Augusta, Ga.)
JID - 9421564
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Male
MH  - *Microcirculation
MH  - Mouth Floor/blood supply
MH  - Regional Blood Flow
MH  - Sepsis/mortality/*pathology/physiopathology
EDAT- 2009/10/24 06:00
MHDA- 2010/07/20 06:00
CRDT- 2009/10/24 06:00
PHST- 2009/10/24 06:00 [entrez]
PHST- 2009/10/24 06:00 [pubmed]
PHST- 2010/07/20 06:00 [medline]
AID - 10.1097/SHK.0b013e3181c6be04 [doi]
PST - ppublish
SO  - Shock. 2010 Apr;33(4):387-91. doi: 10.1097/SHK.0b013e3181c6be04.


PMID- 19851095
OWN - NLM
STAT- MEDLINE
DCOM- 20100115
LR  - 20101118
IS  - 1530-0293 (Electronic)
IS  - 0090-3493 (Linking)
VI  - 38
IP  - 1
DP  - 2010 Jan
TI  - Kidney donation from children after cardiac death.
PG  - 249-53
LID - 10.1097/CCM.0b013e3181c025fd [doi]
AB  - OBJECTIVE: Pediatric kidney donation after cardiac death is an underutilized
      donor source because of ethical concerns and limited knowledge of the outcome
      after transplantation. The purpose of this study was to report the Dutch
      experience of kidney transplantation using pediatric donation after cardiac
      death. DESIGN: Observational cohort study of a series of consecutive kidney
      transplantations from pediatric donation after cardiac death from January 1995 to
      July 2006. SETTING: Kidneys were procured in seven Dutch procurement areas.
      PATIENTS: Recipients of kidneys from donors after cardiac death aged 2 to 17 yrs.
      MEASUREMENTS AND MAIN RESULTS: Prospectively collected data from the Dutch Organ 
      Transplant Registry were analyzed. Donor, graft, and recipient characteristics of
      all pediatric donations after cardiac death kidney transplantations were
      documented. Recipients were followed-up for glomerular filtration rate, graft,
      and patient survival. Eighty-eight patients were transplanted with 90 pediatric
      donation-after-cardiac-death kidneys, which was 31% of the total number of
      transplanted pediatric donor kidneys. In 77% of recipients, organs were procured 
      from controlled donors, after withdrawal of supportive treatment. Of all donors, 
      9% were younger than age 6 yrs. Two patients received their graft preemptively.
      In the others, the incidence of immediate function, delayed graft function, and
      primary nonfunction were 49%, 44%, and 7%, respectively. Warm ischemia time > or 
      =25 mins was associated with primary nonfunction. Overall graft and patient
      survival 5 yrs after transplantation were 80% and 88%, respectively. Graft
      survival after immediate function and delayed graft function was not different.
      CONCLUSIONS: Kidneys from pediatric donation after cardiac death are suitable for
      transplantation and may substantially expand the donor pool with good transplant 
      outcome.
FAU - de Vries, Eva E
AU  - de Vries EE
AD  - Maastricht University Medical Center, General Surgery, Maastricht, Netherlands.
      eefje22@hotmail.com
FAU - Snoeijs, Maarten G
AU  - Snoeijs MG
FAU - van Heurn, Ernest
AU  - van Heurn E
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Crit Care Med
JT  - Critical care medicine
JID - 0355501
SB  - IM
CIN - Crit Care Med. 2010 Jan;38(1):333. PMID: 20023490
MH  - Adolescent
MH  - Age Factors
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - *Death
MH  - Delayed Graft Function
MH  - Female
MH  - Graft Rejection
MH  - Graft Survival
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Kidney Transplantation/ethics/*methods/mortality
MH  - Male
MH  - Netherlands
MH  - Probability
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Sex Factors
MH  - Statistics, Nonparametric
MH  - Survival Analysis
MH  - *Tissue Donors
MH  - Tissue and Organ Harvesting
MH  - Tissue and Organ Procurement/*ethics/trends
EDAT- 2009/10/24 06:00
MHDA- 2010/01/16 06:00
CRDT- 2009/10/24 06:00
PHST- 2009/10/24 06:00 [entrez]
PHST- 2009/10/24 06:00 [pubmed]
PHST- 2010/01/16 06:00 [medline]
AID - 10.1097/CCM.0b013e3181c025fd [doi]
PST - ppublish
SO  - Crit Care Med. 2010 Jan;38(1):249-53. doi: 10.1097/CCM.0b013e3181c025fd.


PMID- 19850649
OWN - NLM
STAT- MEDLINE
DCOM- 20100615
LR  - 20151119
IS  - 1651-1905 (Electronic)
IS  - 1403-4948 (Linking)
VI  - 38
IP  - 4
DP  - 2010 Jun
TI  - Predictive validity of common mental disorders screening questionnaire as a
      screening instrument in long term sickness absence.
PG  - 375-85
LID - 10.1177/1403494809350520 [doi]
AB  - AIMS: Screening instruments for detection of common mental disorders have not
      been validity tested in long term sickness absence (LSA), which is the aim of
      this study for the Common Mental Disorders Screening Questionnaire (CMD-SQ).
      METHODS: Of all 2,414 incident persons on continuous sick-leave for more than
      eight weeks in a Danish population of 120,000 inhabitants 1,121 participated in a
      two-phased study by being screened for mental disorders by CMD-SQ in Phase 1. A
      subgroup of 337 was examined by a psychiatrist and diagnosed with Present State
      Examination in Phase 2. Results performed on Phase 2 were weighted up to Phase 1.
      Test performance was analyzed by ROC-analyses, and the fraction with a positive
      screening test, Q, the sensitivity SE, and 1 minus the specificity, SP, were
      plotted against decreasing cut-point in the tested scales for specific diagnostic
      groups. RESULTS: A sub-scale in CMD-SQ, SCL-8AD, compiled of SCL-ANX4, SCL-8, and
      SCL-DEP6, showed the best psychometric properties in detection of any mental
      disorder (AUC 0.80). Other scales were tested as well. The psychometric
      properties were dependent on sex and age. The plots of Q, SE, and 1-SP against
      decreasing cut-point gave a comprehensive view of the performance of the scales, 
      which could be of significance in addressing the ethical aspects of screening.
      CONCLUSIONS: SCL-8AD is a promising candidate for the screening of mental
      disorders in LSA. It is intended to be administered by the social services
      because in Denmark there is not a legal requirement that sick-listed persons are 
      certified as sick by a physician.
FAU - Sogaard, Hans Jorgen
AU  - Sogaard HJ
AD  - Central Denmark Region, Regional Psychiatric Services, Herning, Denmark.
      hjsoegaard@dadlnet.dk
FAU - Bech, Per
AU  - Bech P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091022
PL  - Sweden
TA  - Scand J Public Health
JT  - Scandinavian journal of public health
JID - 100883503
SB  - IM
MH  - *Absenteeism
MH  - Adult
MH  - Denmark/epidemiology
MH  - Disability Evaluation
MH  - Family Practice
MH  - Female
MH  - Humans
MH  - Male
MH  - Mass Screening
MH  - Mental Disorders/*diagnosis/epidemiology
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Psychometrics/methods
MH  - ROC Curve
MH  - Sensitivity and Specificity
MH  - *Sick Leave
MH  - *Surveys and Questionnaires
EDAT- 2009/10/24 06:00
MHDA- 2010/06/16 06:00
CRDT- 2009/10/24 06:00
PHST- 2009/10/24 06:00 [entrez]
PHST- 2009/10/24 06:00 [pubmed]
PHST- 2010/06/16 06:00 [medline]
AID - 1403494809350520 [pii]
AID - 10.1177/1403494809350520 [doi]
PST - ppublish
SO  - Scand J Public Health. 2010 Jun;38(4):375-85. doi: 10.1177/1403494809350520. Epub
      2009 Oct 22.


PMID- 19850557
OWN - NLM
STAT- MEDLINE
DCOM- 20110314
LR  - 20140730
IS  - 1522-9645 (Electronic)
IS  - 0195-668X (Linking)
VI  - 31
IP  - 3
DP  - 2010 Feb
TI  - Aortic remodelling in Fabry disease.
PG  - 347-53
LID - 10.1093/eurheartj/ehp426 [doi]
AB  - AIMS: To evaluate thoracic aortic dilation in patients with Fabry disease (FD).
      METHODS AND RESULTS: A cohort of 106 patients with FD (52 males; 54 females) from
      three European centres were studied. The diameter of the thoracic aorta was
      assessed at three levels (sinus of Valsalva, ascending aorta, and descending
      aorta) using echocardiograms and cardiovascular magnetic resonance imaging.
      Aortic dilation at the sinus of Valsalva was found in 32.7% of males and 5.6% of 
      females; aneurysms were present in 9.6% of males and 1.9% of females. No aortic
      dilation was observed in the descending aorta. There was no correlation between
      aortic diameter at the sinus of Valsalva and cardiovascular risk factors.
      CONCLUSION: Fabry disease should be considered as a cardiovascular disease that
      affects the heart and arterial vasculature, including the thoracic aorta. Thus,
      patients with FD should be closely monitored for the presence, and possible
      progression and complications of aortic dilation. CLINICAL TRIAL REGISTRATION:
      Protocol 101/01. Ethics committee, Faculty of Medicine, Lausanne.
FAU - Barbey, Frederic
AU  - Barbey F
AD  - Department of Transplantation, Faculty of Medicine and Biology, University
      Hospital, Lausanne, Switzerland. frederic.barbey@chuv.ch
FAU - Qanadli, Salah D
AU  - Qanadli SD
FAU - Juli, Christoph
AU  - Juli C
FAU - Brakch, Noureddine
AU  - Brakch N
FAU - Palacek, Tomas
AU  - Palacek T
FAU - Rizzo, Elena
AU  - Rizzo E
FAU - Jeanrenaud, Xavier
AU  - Jeanrenaud X
FAU - Eckhardt, Boris
AU  - Eckhardt B
FAU - Linhart, Ales
AU  - Linhart A
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091021
PL  - England
TA  - Eur Heart J
JT  - European heart journal
JID - 8006263
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aortic Aneurysm, Thoracic/*pathology
MH  - Echocardiography
MH  - Fabry Disease/*pathology/physiopathology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Angiography
MH  - Male
MH  - Middle Aged
MH  - Sinus of Valsalva/pathology
MH  - Young Adult
EDAT- 2009/10/24 06:00
MHDA- 2011/03/15 06:00
CRDT- 2009/10/24 06:00
PHST- 2009/10/24 06:00 [entrez]
PHST- 2009/10/24 06:00 [pubmed]
PHST- 2011/03/15 06:00 [medline]
AID - ehp426 [pii]
AID - 10.1093/eurheartj/ehp426 [doi]
PST - ppublish
SO  - Eur Heart J. 2010 Feb;31(3):347-53. doi: 10.1093/eurheartj/ehp426. Epub 2009 Oct 
      21.


PMID- 19850531
OWN - NLM
STAT- MEDLINE
DCOM- 20100603
LR  - 20101118
IS  - 1532-1932 (Electronic)
IS  - 1521-6934 (Linking)
VI  - 24
IP  - 1
DP  - 2010 Feb
TI  - Ovarian tissue cryopreservation and transplantation in cancer patients.
PG  - 87-100
LID - 10.1016/j.bpobgyn.2009.09.003 [doi]
AB  - Advances in the diagnosis and treatment of childhood, adolescent and adult cancer
      have greatly increased the life expectancy of premenopausal women with cancer.
      The ovaries are very sensitive to cytotoxic treatment, especially to alkylating
      agents. The only established method of fertility preservation is embryo
      cryopreservation according to the Ethics Committee of the American Society for
      Reproductive Medicine (2005), but this option requires the patient to be of
      pubertal age, have a partner or use donor sperm and be able to undergo a cycle of
      ovarian stimulation, which is not possible when the chemotherapy has to be
      initiated immediately or when stimulation is contraindicated, according to the
      type of cancer. For patients who need immediate chemotherapy, cryopreservation of
      ovarian tissue is the only possible alternative. This article reports the
      techniques and results of orthotopic transplantation of cryopreserved ovarian
      tissue. Among almost 30 cases reported in the literature, six live births have
      been achieved to date.
FAU - Donnez, Jacques
AU  - Donnez J
AD  - Department of Gynecology, Universite Catholique de Louvain, 1200 Brussels,
      Belgium. donnez@gyne.ucl.ac.be <donnez@gyne.ucl.ac.be>
FAU - Jadoul, Pascale
AU  - Jadoul P
FAU - Squifflet, Jean
AU  - Squifflet J
FAU - Van Langendonckt, Anne
AU  - Van Langendonckt A
FAU - Donnez, Olivier
AU  - Donnez O
FAU - Van Eyck, Anne-Sophie
AU  - Van Eyck AS
FAU - Marinescu, Cristina
AU  - Marinescu C
FAU - Dolmans, Marie-Madeleine
AU  - Dolmans MM
LA  - eng
PT  - Journal Article
DEP - 20091021
PL  - Netherlands
TA  - Best Pract Res Clin Obstet Gynaecol
JT  - Best practice & research. Clinical obstetrics & gynaecology
JID - 101121582
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Adult
MH  - Antineoplastic Agents/administration & dosage/*adverse effects
MH  - *Cryopreservation/methods
MH  - *Embryo Transfer
MH  - Evidence-Based Medicine
MH  - Female
MH  - *Fertilization in Vitro
MH  - Humans
MH  - Infertility, Female/chemically induced/*prevention & control
MH  - Oocytes/transplantation
MH  - Ovarian Neoplasms/*drug therapy/therapy
MH  - Ovary/*transplantation
MH  - Ovulation Induction/methods
MH  - Practice Guidelines as Topic
MH  - Pregnancy
MH  - Primary Ovarian Insufficiency/chemically induced/prevention & control
MH  - Replantation
MH  - Risk Assessment
MH  - Risk Factors
EDAT- 2009/10/24 06:00
MHDA- 2010/06/04 06:00
CRDT- 2009/10/24 06:00
PHST- 2009/03/24 00:00 [received]
PHST- 2009/08/19 00:00 [revised]
PHST- 2009/09/02 00:00 [accepted]
PHST- 2009/10/24 06:00 [entrez]
PHST- 2009/10/24 06:00 [pubmed]
PHST- 2010/06/04 06:00 [medline]
AID - S1521-6934(09)00117-5 [pii]
AID - 10.1016/j.bpobgyn.2009.09.003 [doi]
PST - ppublish
SO  - Best Pract Res Clin Obstet Gynaecol. 2010 Feb;24(1):87-100. doi:
      10.1016/j.bpobgyn.2009.09.003. Epub 2009 Oct 21.


PMID- 19850443
OWN - NLM
STAT- MEDLINE
DCOM- 20100727
LR  - 20161125
IS  - 1557-8615 (Electronic)
IS  - 0883-9441 (Linking)
VI  - 25
IP  - 2
DP  - 2010 Jun
TI  - Extubation versus tracheostomy in withdrawal of treatment-ethical, clinical, and 
      legal perspectives.
PG  - 360.e1-8
LID - 10.1016/j.jcrc.2009.08.007 [doi]
AB  - The provision of life-sustaining ventilation, such as tracheostomy to critically 
      ill patients, is commonly performed. However, the utilization of tracheostomy or 
      extubation after a withdrawal of treatment decision is debated. There is a dearth
      of practical information available to aid clinical decision making because
      withdrawal of treatment is a challenging scenario for all concerned. This is
      further complicated by medicolegal and ethical considerations. Care of the
      "hopelessly ill" patient should be based on daily evaluation and comfort making
      it impossible to fit into general algorithms. Although respect for autonomy is
      important in healthcare, it is limited for patients in an unconscious state.
      Beneficence remains the basis for withdrawing treatment in futile cases and
      underpins the "doctrine of double effect." This article presents a relevant
      clinical case of hypoxic brain injury where a question of withdrawal of treatment
      arose and examines the ethical, clinical, and medicolegal considerations inherent
      in such cases, including beneficence, nonmaleficence, and the "sanctity of life
      doctrine." In addition, the considerations of prognosis for recovery, patient
      autonomy, patient quality of life, and patient family involvement, which are
      central to decision making, are addressed. The varying legal frameworks that
      exist internationally regarding treatment withdrawal are also described. Good
      ethics needs sound facts, and despite the lack of legal foundation in several
      countries, withdrawal of treatment remains practiced, and the principles
      described within this article aim to aid clinician decision making during such
      complex and multifaceted end-of-life decisions.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Chotirmall, Sanjay Haresh
AU  - Chotirmall SH
AD  - Department of Medicine - Respiratory Research Division, Royal College of Surgeons
      in Ireland, Education & Research Centre, Beaumont Hospital, Dublin 9, Republic of
      Ireland. schotirmall@rcsi.ie
FAU - Flynn, Maura G
AU  - Flynn MG
FAU - Donegan, Ciaran F
AU  - Donegan CF
FAU - Smith, David
AU  - Smith D
FAU - O'Neill, Shane J
AU  - O'Neill SJ
FAU - McElvaney, Noel Gerard
AU  - McElvaney NG
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20091021
PL  - United States
TA  - J Crit Care
JT  - Journal of critical care
JID - 8610642
SB  - IM
CIN - J Crit Care. 2010 Dec;25(4):651; author reply 652. PMID: 21109126
MH  - Adult
MH  - Beneficence
MH  - Critical Care/*ethics/legislation & jurisprudence
MH  - Decision Making
MH  - Humans
MH  - Hypoxia, Brain/therapy
MH  - *Intubation, Intratracheal
MH  - Male
MH  - Personal Autonomy
MH  - Professional-Family Relations
MH  - Prognosis
MH  - Quality of Life
MH  - *Tracheostomy
MH  - United Kingdom
MH  - Value of Life
MH  - Withholding Treatment/*ethics/*legislation & jurisprudence
EDAT- 2009/10/24 06:00
MHDA- 2010/07/28 06:00
CRDT- 2009/10/24 06:00
PHST- 2009/03/18 00:00 [received]
PHST- 2009/07/02 00:00 [revised]
PHST- 2009/08/22 00:00 [accepted]
PHST- 2009/10/24 06:00 [entrez]
PHST- 2009/10/24 06:00 [pubmed]
PHST- 2010/07/28 06:00 [medline]
AID - S0883-9441(09)00231-7 [pii]
AID - 10.1016/j.jcrc.2009.08.007 [doi]
PST - ppublish
SO  - J Crit Care. 2010 Jun;25(2):360.e1-8. doi: 10.1016/j.jcrc.2009.08.007. Epub 2009 
      Oct 21.


PMID- 19845887
OWN - NLM
STAT- MEDLINE
DCOM- 20100922
LR  - 20100517
IS  - 1471-6712 (Electronic)
IS  - 0283-9318 (Linking)
VI  - 24
IP  - 1
DP  - 2010 Mar
TI  - Ethical dilemmas: a resource in public health nurses' everyday work?
PG  - 75-83
LID - 10.1111/j.1471-6712.2009.00688.x [doi]
AB  - The aim of this article is to discuss how ethical dilemmas can be a valuable
      resource in public health nurses' parent counselling practice. The discussion is 
      based on findings from a study where ten Norwegian public health nurses'
      narratives about their parent counselling practices are analysed. The context
      includes intentions and manuals from a state parent counselling program. The
      study has been approved by Norwegian Social Science Data Services. The narratives
      provide insight into public health nurses' rationale behind choices of actions,
      different roles they identify with and the ethical dilemmas they encounter in
      their everyday work. The ethical dilemmas explicated in the narratives, are
      connected to expectations concerning the content of parent counselling, as well
      as the role of the participants in the counselling sessions. The focus on ethical
      dilemmas that arises through different role-expectations, explicates how public
      health nurses' counselling practices are characterized by a multiplicity of
      voices and discourses. This article shows how a multiple-voiced aspect allows
      public health nurses to change and adjust their practice to meet parents' wishes 
      and needs, without being disloyal to what they perceive to be their public
      commission.
FAU - Fjetland, Kirsten J
AU  - Fjetland KJ
AD  - Diakonhjemmet University College Rogaland, Vagsgaten, Sandnes, Norway.
      kirsten.j.fjetland@diakonhjemmeths.no
FAU - Soreide, Gunn Elisabeth
AU  - Soreide GE
LA  - eng
PT  - Journal Article
DEP - 20091021
PL  - Sweden
TA  - Scand J Caring Sci
JT  - Scandinavian journal of caring sciences
JID - 8804206
MH  - *Ethics, Professional
MH  - Humans
MH  - Nursing
MH  - Public Health Nursing/*ethics
EDAT- 2009/10/23 06:00
MHDA- 2010/09/24 06:00
CRDT- 2009/10/23 06:00
PHST- 2009/10/23 06:00 [entrez]
PHST- 2009/10/23 06:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
AID - SCS688 [pii]
AID - 10.1111/j.1471-6712.2009.00688.x [doi]
PST - ppublish
SO  - Scand J Caring Sci. 2010 Mar;24(1):75-83. doi: 10.1111/j.1471-6712.2009.00688.x. 
      Epub 2009 Oct 21.


PMID- 19843702
OWN - NLM
STAT- MEDLINE
DCOM- 20101026
LR  - 20220330
IS  - 1524-8399 (Print)
IS  - 1524-8399 (Linking)
VI  - 11
IP  - 3
DP  - 2010 May
TI  - Promoting policy and environmental change using photovoice in the Kaiser
      Permanente Community Health Initiative.
PG  - 332-9
LID - 10.1177/1524839909341555 [doi]
AB  - Creative ways must be found to engage both community residents and political
      leaders around policy and environmental solutions to public health issues.
      Photovoice is a community-based, participatory approach to documentary
      photography that provides people with training on photography, ethics, critical
      discussion, and policy advocacy. Photovoice projects have been implemented across
      the nation as part of Kaiser Permanente's Community Health Initiative-a
      community-based obesity prevention effort. This article focuses on the first
      Photovoice project implemented in three communities in Colorado. Photovoice
      themes related to healthy eating and active living include a lack of access to
      healthy food choices in stores and schools, unsafe street crossings and
      sidewalks, and the need to redevelop certain areas to encourage safe recreation. 
      The involvement of policy leaders in the project combined with several
      dissemination activities has contributed to healthier food offerings in schools
      and neighborhoods and city planning efforts that emphasize walkability and access
      to healthy food, and park revitalization.
FAU - Kramer, Leila
AU  - Kramer L
AD  - Center for Community Health and Evaluation and a community hospital in Santa
      Cruz, California, USA.
FAU - Schwartz, Pamela
AU  - Schwartz P
FAU - Cheadle, Allen
AU  - Cheadle A
FAU - Borton, J Elaine
AU  - Borton JE
FAU - Wright, Merrick
AU  - Wright M
FAU - Chase, Charlie
AU  - Chase C
FAU - Lindley, Corina
AU  - Lindley C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091020
PL  - United States
TA  - Health Promot Pract
JT  - Health promotion practice
JID - 100890609
SB  - IM
MH  - Colorado
MH  - Community Health Services
MH  - *Community Networks
MH  - Community-Based Participatory Research
MH  - *Community-Institutional Relations
MH  - *Consumer Advocacy
MH  - Environment Design
MH  - Health Behavior
MH  - Health Maintenance Organizations
MH  - Health Policy
MH  - Health Promotion/*methods
MH  - Humans
MH  - Obesity/prevention & control
MH  - *Photography
MH  - Policy Making
MH  - Safety
EDAT- 2009/10/22 06:00
MHDA- 2010/10/27 06:00
CRDT- 2009/10/22 06:00
PHST- 2009/10/22 06:00 [entrez]
PHST- 2009/10/22 06:00 [pubmed]
PHST- 2010/10/27 06:00 [medline]
AID - 1524839909341555 [pii]
AID - 10.1177/1524839909341555 [doi]
PST - ppublish
SO  - Health Promot Pract. 2010 May;11(3):332-9. doi: 10.1177/1524839909341555. Epub
      2009 Oct 20.


PMID- 19842011
OWN - NLM
STAT- MEDLINE
DCOM- 20100615
LR  - 20220321
IS  - 1432-1459 (Electronic)
IS  - 0340-5354 (Linking)
VI  - 257
IP  - 3
DP  - 2010 Mar
TI  - Modafinil for Parkinson's disease fatigue.
PG  - 452-6
LID - 10.1007/s00415-009-5351-8 [doi]
AB  - Fatigue is common in Parkinson's disease (PD), occurring in up to 42% of patients
      (2). There is no recognized treatment. This is a study of modafinil for
      Parkinson's disease related fatigue. Ethical approval was given. Patients with
      idiopathic PD were recruited from a Movement Disorders clinic. Those with
      depression, dementia, and other causes for fatigue were excluded. Patients were
      assessed using the Fatigue Severity Scale (FSS), Hospital Anxiety and Depression 
      Scale (HADS), self-rating of improvement, Epworth Sleepiness Scale (ESS), and
      UPDRS. Modafinil was titrated up over 4 weeks to maximum of 400 mg/day. There
      followed a 5 week maintenance phase before reassessment. Thirteen patients
      participated. No significant change was seen in any safety measure. The FSS did
      not change significantly, however those on modafinil rated an improvement in
      their fatigue compared to placebo. The Modafinil group had a statistically
      significant improvement on ESS (p < 0.05). This is a small study of modafinil in 
      selected PD patients. There is a suggestion of improvement on the global clinical
      impression scale for fatigue, but no significant change on FSS. A larger study is
      needed to further evaluate this drug in PD fatigue. This study highlights the
      problems with recruitment when trialing treatments of non-motor symptoms in PD. A
      significant improvement in EDS was seen.
FAU - Tyne, Hilary L
AU  - Tyne HL
AD  - Department of Neurological Sciences, University of Liverpool, The Walton Centre
      for Neurology and Neurosurgery, Lower Lane, Liverpool, L9 7LJ, UK.
      htyne@ukonline.co.uk
FAU - Taylor, Joanne
AU  - Taylor J
FAU - Baker, Gus A
AU  - Baker GA
FAU - Steiger, Malcolm J
AU  - Steiger MJ
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20091020
PL  - Germany
TA  - J Neurol
JT  - Journal of neurology
JID - 0423161
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Central Nervous System Stimulants)
RN  - R3UK8X3U3D (Modafinil)
SB  - IM
MH  - Aged
MH  - Benzhydryl Compounds/adverse effects/*pharmacology/therapeutic use
MH  - Central Nervous System Stimulants/adverse effects/pharmacology/therapeutic use
MH  - Disability Evaluation
MH  - Dose-Response Relationship, Drug
MH  - Double-Blind Method
MH  - Drug Administration Schedule
MH  - Fatigue Syndrome, Chronic/*drug therapy/*etiology/physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Modafinil
MH  - Outcome Assessment, Health Care
MH  - Parkinson Disease/*complications
MH  - Patient Selection
MH  - Severity of Illness Index
MH  - Treatment Outcome
EDAT- 2009/10/21 06:00
MHDA- 2010/06/16 06:00
CRDT- 2009/10/21 06:00
PHST- 2009/04/24 00:00 [received]
PHST- 2009/09/29 00:00 [accepted]
PHST- 2009/09/27 00:00 [revised]
PHST- 2009/10/21 06:00 [entrez]
PHST- 2009/10/21 06:00 [pubmed]
PHST- 2010/06/16 06:00 [medline]
AID - 10.1007/s00415-009-5351-8 [doi]
PST - ppublish
SO  - J Neurol. 2010 Mar;257(3):452-6. doi: 10.1007/s00415-009-5351-8. Epub 2009 Oct
      20.


PMID- 19841941
OWN - NLM
STAT- MEDLINE
DCOM- 20100726
LR  - 20211020
IS  - 1432-1076 (Electronic)
IS  - 0340-6199 (Linking)
VI  - 169
IP  - 6
DP  - 2010 Jun
TI  - Ethical principles and recommendations for the medical management of differences 
      of sex development (DSD)/intersex in children and adolescents.
PG  - 671-9
LID - 10.1007/s00431-009-1086-x [doi]
AB  - UNLABELLED: The medical management of differences of sex development
      (DSD)/intersex in early childhood has been criticized by patients' advocates as
      well as bioethicists from an ethical point of view. Some call for a moratorium of
      any feminizing or masculinizing operations before the age of consent except for
      medical emergencies. No exhaustive ethical guidelines have been published until
      now. In particular, the role of the parents as legal representatives of the child
      is controversial. In the article, we develop, discuss, and present ethical
      principles and recommendations for the medical management of intersex/DSD in
      children and adolescents. We specify three basic ethical principles that have to 
      be respected and substantiate them. The article includes a critical discussion of
      the best interest of the child and of family privacy. The argumentation draws
      upon recommendations by the working group "Bioethics and Intersex" within the
      German Network DSD/Intersex, which are presented in detail. Unlike other
      recommendations with regard to intersex, these guidelines represent a
      comprehensive view of the perspectives of clinicians, patients, and their
      families. CONCLUSION: The working group identified three leading ethical
      principles that apply to DSD management: (1) to foster the well-being of the
      child and the future adult, (2) to uphold the rights of children and adolescents 
      to participate in and/or self-determine decisions that affect them now or later, 
      and (3) to respect the family and parent-child relationships. Nine
      recommendations for the management of DSD indicate how these ethical principles
      can spelled out and balanced against each other in the clinical setting.
FAU - Wiesemann, Claudia
AU  - Wiesemann C
AD  - Department for Medical Ethics and History of Medicine, Gottingen University,
      Humboldtallee 36, 37073 Gottingen, Germany. cwiesem@gwdg.de
FAU - Ude-Koeller, Susanne
AU  - Ude-Koeller S
FAU - Sinnecker, Gernot H G
AU  - Sinnecker GH
FAU - Thyen, Ute
AU  - Thyen U
LA  - eng
PT  - Journal Article
DEP - 20091020
PL  - Germany
TA  - Eur J Pediatr
JT  - European journal of pediatrics
JID - 7603873
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child Welfare
MH  - Child, Preschool
MH  - Decision Making/*ethics
MH  - Disorders of Sex Development/*therapy
MH  - Ethics, Medical
MH  - Germany
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Informed Consent/ethics
MH  - International Cooperation
MH  - Parent-Child Relations
MH  - Personal Autonomy
MH  - Practice Guidelines as Topic
PMC - PMC2859219
EDAT- 2009/10/21 06:00
MHDA- 2010/07/27 06:00
CRDT- 2009/10/21 06:00
PHST- 2009/03/08 00:00 [received]
PHST- 2009/09/09 00:00 [accepted]
PHST- 2009/10/21 06:00 [entrez]
PHST- 2009/10/21 06:00 [pubmed]
PHST- 2010/07/27 06:00 [medline]
AID - 10.1007/s00431-009-1086-x [doi]
PST - ppublish
SO  - Eur J Pediatr. 2010 Jun;169(6):671-9. doi: 10.1007/s00431-009-1086-x. Epub 2009
      Oct 20.


PMID- 19836117
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20161125
IS  - 1532-2793 (Electronic)
IS  - 0260-6917 (Linking)
VI  - 30
IP  - 3
DP  - 2010 Apr
TI  - Identifying common competences in health and social care: an example of
      multi-institutional and inter-professional working.
PG  - 264-70
LID - 10.1016/j.nedt.2009.09.006 [doi]
AB  - Students taking programmes of study leading to registration as a nurse or other
      health and social care professional, must be assessed in practice to ensure that 
      they are competent in a range of skills. As practice placements become more
      difficult to source, the use of inter-professional assessment is becoming an
      increasingly important facet of assessment for students in health and social
      care. This paper describes an innovate collaborative project across 5 Higher
      Education Institutions and 16 professional groups to develop maps to assess
      communication, team working and ethical practice, three essential competences for
      all health professionals. The process used to develop each competency map is
      detailed along with discussion of the consultation process with professional
      statutory and regulatory bodies, practice based and academic staff and service
      users and carers. The completed project is evidence of successful
      multi-institutional and inter-professional working to develop assessment
      processes which accurately and fairly measure capabilities to help students
      develop into proficient and effective practitioners.
FAU - Holt, Janet
AU  - Holt J
AD  - School of Healthcare, University of Leeds, Leeds LS2 9JT, UK. hcsjh@leeds.ac.uk
      <hcsjh@leeds.ac.uk>
FAU - Coates, Catherine
AU  - Coates C
FAU - Cotterill, Diane
AU  - Cotterill D
FAU - Eastburn, Sara
AU  - Eastburn S
FAU - Laxton, Julie
AU  - Laxton J
FAU - Mistry, Helen
AU  - Mistry H
FAU - Young, Carol
AU  - Young C
LA  - eng
PT  - Journal Article
PL  - Scotland
TA  - Nurse Educ Today
JT  - Nurse education today
JID - 8511379
MH  - Communication
MH  - Education, Nursing/*standards
MH  - Ethics, Professional
MH  - Humans
MH  - Interpersonal Relations
MH  - *Interprofessional Relations
MH  - *Leadership
MH  - *Professional Competence
MH  - Program Evaluation
MH  - Social Work/*education
MH  - United Kingdom
EDAT- 2009/10/20 06:00
MHDA- 2011/01/07 06:00
CRDT- 2009/10/20 06:00
PHST- 2009/04/07 00:00 [received]
PHST- 2009/07/30 00:00 [revised]
PHST- 2009/09/03 00:00 [accepted]
PHST- 2009/10/20 06:00 [entrez]
PHST- 2009/10/20 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
AID - S0260-6917(09)00172-5 [pii]
AID - 10.1016/j.nedt.2009.09.006 [doi]
PST - ppublish
SO  - Nurse Educ Today. 2010 Apr;30(3):264-70. doi: 10.1016/j.nedt.2009.09.006.


PMID- 19833859
OWN - NLM
STAT- MEDLINE
DCOM- 20100309
LR  - 20100114
IS  - 1758-1060 (Electronic)
IS  - 1355-8196 (Linking)
VI  - 15
IP  - 1
DP  - 2010 Jan
TI  - The desirability of being open about health care rationing decisions: findings
      from a qualitative study of patients and clinical professionals.
PG  - 14-20
LID - 10.1258/jhsrp.2009.009045 [doi]
AB  - OBJECTIVE: To understand the views of patients and professionals about how
      feasible and appropriate it is to make health care rationing decisions openly at 
      the consultation level. METHODS: Thirty-one patients and 21 health care
      professionals were asked about their experiences of implicit and explicit
      rationing during in-depth interviews structured around two clinical case studies 
      (morbid obesity and breast cancer). Sampling was undertaken theoretically and
      data analysis was carried out using constant comparison. RESULTS: Patients had a 
      broad awareness of health care rationing and nearly all said they wanted to know 
      how financial factors affected the provision of their health care. However, the
      experience of explicit rationing could be distressing and one patient regretted
      having been told. Despite a firm commitment to the ideal of being open with
      patients about rationing, in practice, clinical professionals encountered a
      number of ethical and practical barriers to making such decisions explicitly,
      meaning that implicit methods were frequently adopted. CONCLUSIONS: The results
      suggest that moves in the UK and elsewhere to undertake rationing more explicitly
      are in line with the preferences of the majority of patients and professionals.
      However, the potential for distress caused through rationing openly means that
      further research is needed to understand whether explicitness is always the best 
      approach at the consultation level, and professionals need further training and
      support to deal with the stressful nature of making rationing decisions openly.
FAU - Owen-Smith, Amanda
AU  - Owen-Smith A
AD  - Department of Social Medicine, University of Bristol, Bristol, UK.
      a.owen-smith@bristol.ac.uk
FAU - Coast, Joanna
AU  - Coast J
FAU - Donovan, Jenny
AU  - Donovan J
LA  - eng
GR  - Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091015
PL  - England
TA  - J Health Serv Res Policy
JT  - Journal of health services research & policy
JID - 9604936
MH  - Adult
MH  - Aged
MH  - *Attitude of Health Personnel
MH  - *Attitude to Health
MH  - Decision Making, Organizational
MH  - Female
MH  - Health Care Rationing/ethics/*organization & administration
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Middle Aged
MH  - Patient Participation/psychology
MH  - Professional-Patient Relations
MH  - Qualitative Research
MH  - Referral and Consultation
MH  - State Medicine/organization & administration
MH  - *Truth Disclosure
MH  - Young Adult
EDAT- 2009/10/17 06:00
MHDA- 2010/03/10 06:00
CRDT- 2009/10/17 06:00
PHST- 2009/10/17 06:00 [entrez]
PHST- 2009/10/17 06:00 [pubmed]
PHST- 2010/03/10 06:00 [medline]
AID - jhsrp.2009.009045 [pii]
AID - 10.1258/jhsrp.2009.009045 [doi]
PST - ppublish
SO  - J Health Serv Res Policy. 2010 Jan;15(1):14-20. doi: 10.1258/jhsrp.2009.009045.
      Epub 2009 Oct 15.


PMID- 19833115
OWN - NLM
STAT- MEDLINE
DCOM- 20100201
LR  - 20101118
IS  - 1873-3492 (Electronic)
IS  - 0009-8981 (Linking)
VI  - 411
IP  - 1-2
DP  - 2010 Jan
TI  - Association of alpha 2A adrenergic receptor gene (ADRAlpha2A) polymorphism with
      irritable bowel syndrome, microscopic and ulcerative colitis.
PG  - 59-63
LID - 10.1016/j.cca.2009.10.003 [doi]
AB  - BACKGROUND: Alpha 2 adrenergic receptors (alpha2 ARs) play a central role in the 
      regulation of systemic sympathetic activity. Prejunctional alpha 2A adrenoceptor 
      regulates through negative feedback at presynaptic nerve ending. A-1291 C>G
      polymorphism located in alpha2-adrenergic receptor gene (ADRAlpha2A) has been
      identified. We investigated the possible association between 1291 C>G
      polymorphism in the promoter region of ADRAlpha2A in clinical subtypes of IBS,
      ulcerative and microscopic colitis patients. METHODS: This prospective case
      control study included 92 patients with diarrhea predominant IBS (D-IBS), 44 with
      constipation predominant IBS (C-IBS), 15 with alternating diarrhea and
      constipation IBS (M-IBS), 75 ulcerative colitis (UC), 41 microscopic colitis (MC)
      and 100 healthy controls. The subjects were genotyped by using PCR amplification 
      of the promoter region of ADRAlpha2A gene followed by digestion with the
      restriction enzyme MspI. The study was approved by the institute ethical
      committee. RESULTS: A strong genotypic association was observed between
      alpha2A-1291 C>G polymorphism and D-IBS (chi2=6.38, df=2, p<0.05). There was no
      significant difference in alpha2A-1291 C>G genotype and allele frequency between 
      C-IBS, M-IBS, UC, MC cases and control subjects. CONCLUSIONS: A significant
      association was observed between alpha2A-1291C>G polymorphism and D-IBS. Thus,
      alpha2 AR gene may be a potential candidate involved in the pathophysiology of
      D-IBS.
FAU - Sikander, Arbab
AU  - Sikander A
AD  - Department of Super Specialty Gastroenterology, Postgraduate Institute of Medical
      Education and Research (PGIMER), Chandigarh, 160012, India.
FAU - Rana, Satya Vati
AU  - Rana SV
FAU - Sharma, Sanjeev K
AU  - Sharma SK
FAU - Sinha, Saroj Kant
AU  - Sinha SK
FAU - Arora, Sunil K
AU  - Arora SK
FAU - Prasad, Kaushal Kishor
AU  - Prasad KK
FAU - Singh, Kartar
AU  - Singh K
LA  - eng
PT  - Journal Article
DEP - 20091013
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (ADRA2A protein, human)
RN  - 0 (DNA Primers)
RN  - 0 (Receptors, Adrenergic, alpha-2)
SB  - IM
MH  - Base Sequence
MH  - Case-Control Studies
MH  - Colitis, Ulcerative/*genetics
MH  - DNA Primers
MH  - Humans
MH  - Irritable Bowel Syndrome/*genetics
MH  - *Polymorphism, Genetic
MH  - Promoter Regions, Genetic
MH  - Prospective Studies
MH  - Receptors, Adrenergic, alpha-2/*genetics
EDAT- 2009/10/17 06:00
MHDA- 2010/02/02 06:00
CRDT- 2009/10/17 06:00
PHST- 2009/03/15 00:00 [received]
PHST- 2009/10/02 00:00 [revised]
PHST- 2009/10/05 00:00 [accepted]
PHST- 2009/10/17 06:00 [entrez]
PHST- 2009/10/17 06:00 [pubmed]
PHST- 2010/02/02 06:00 [medline]
AID - S0009-8981(09)00530-0 [pii]
AID - 10.1016/j.cca.2009.10.003 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2010 Jan;411(1-2):59-63. doi: 10.1016/j.cca.2009.10.003. Epub
      2009 Oct 13.


PMID- 19832885
OWN - NLM
STAT- MEDLINE
DCOM- 20110105
LR  - 20211020
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 10
IP  - 3
DP  - 2010 Dec
TI  - Research integrity in China: problems and prospects.
PG  - 164-71
LID - 10.1111/j.1471-8847.2009.00263.x [doi]
AB  - In little more than 30 years, China has recovered from the intellectual
      stagnation brought about by the Cultural Revolution to become a global leader in 
      science and technology. Like other leading countries in science and technology,
      China has encountered some ethical problems related to the conduct of research.
      China's leaders have taken some steps to respond to these problems, such as
      developing ethics policies and establishing oversight committees. To keep moving 
      forward, China needs to continue to take effective action to promote research
      integrity. Some of the challenges China faces include additional policy
      development, promoting education in responsible conduct of research, protecting
      whistle-blowers, and cultivating an ethical research environment.
CI  - Published 2009.
FAU - Zeng, Weiqin
AU  - Zeng W
AD  - NIEHS/NIH, Box 12233 Mail Drop NH06, Research Triangle Park, North Carolina
      27709, USA.
FAU - Resnik, David
AU  - Resnik D
LA  - eng
GR  - Z99 ES999999/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
SB  - IM
MH  - China
MH  - *Conflict of Interest
MH  - *Ethics, Research
MH  - Financing, Government
MH  - Humans
MH  - International Cooperation
MH  - Public Policy
MH  - *Scientific Misconduct/ethics/trends
MH  - Universities
MH  - *Whistleblowing
PMC - PMC2891906
MID - NIHMS141740
EDAT- 2009/10/17 06:00
MHDA- 2011/01/06 06:00
CRDT- 2009/10/17 06:00
PHST- 2009/10/17 06:00 [entrez]
PHST- 2009/10/17 06:00 [pubmed]
PHST- 2011/01/06 06:00 [medline]
AID - DEWB263 [pii]
AID - 10.1111/j.1471-8847.2009.00263.x [doi]
PST - ppublish
SO  - Dev World Bioeth. 2010 Dec;10(3):164-71. doi: 10.1111/j.1471-8847.2009.00263.x.


PMID- 19831641
OWN - NLM
STAT- MEDLINE
DCOM- 20100421
LR  - 20220408
IS  - 1937-3376 (Electronic)
IS  - 1937-3368 (Linking)
VI  - 16
IP  - 1
DP  - 2010 Feb
TI  - Animal models for cartilage regeneration and repair.
PG  - 105-15
LID - 10.1089/ten.TEB.2009.0452 [doi]
AB  - Articular cartilage injury and degeneration are leading causes of disability.
      Animal studies are critically important to developing effective treatments for
      cartilage injuries. This review focuses on the use of animal models for the study
      of the repair and regeneration of focal cartilage defects. Animals commonly used 
      in cartilage repair studies include murine, lapine, canine, caprine, porcine, and
      equine models. There are advantages and disadvantages to each model. Small animal
      rodent and lapine models are cost effective, easy to house, and useful for pilot 
      and proof-of-concept studies. The availability of transgenic and knockout mice
      provide opportunities for mechanistic in vivo study. Athymic mice and rats are
      additionally useful for evaluating the cartilage repair potential of human cells 
      and tissues. Their small joint size, thin cartilage, and greater potential for
      intrinsic healing than humans, however, limit the translational value of small
      animal models. Large animal models with thicker articular cartilage permit study 
      of both partial thickness and full thickness chondral repair, as well as
      osteochondral repair. Joint size and cartilage thickness for canine, caprine, and
      mini-pig models remain significantly smaller than that of humans. The repair and 
      regeneration of chondral and osteochondral defects of size and volume comparable 
      to that of clinically significant human lesions can be reliably studied primarily
      in equine models. While larger animals may more closely approximate the human
      clinical situation, they carry greater logistical, financial, and ethical
      considerations. A multifactorial analysis of each animal model should be carried 
      out when planning in vivo studies. Ultimately, the scientific goals of the study 
      will be critical in determining the appropriate animal model.
FAU - Chu, Constance R
AU  - Chu CR
AD  - Cartilage Restoration Laboratory, Department of Orthopaedic Surgery, University
      of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA. chucr@upmc.edu
FAU - Szczodry, Michal
AU  - Szczodry M
FAU - Bruno, Stephen
AU  - Bruno S
LA  - eng
GR  - R01 AR051963/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Tissue Eng Part B Rev
JT  - Tissue engineering. Part B, Reviews
JID - 101466660
SB  - IM
MH  - Animals
MH  - Cartilage, Articular/*physiology
MH  - *Disease Models, Animal
MH  - Humans
MH  - Regeneration/*physiology
MH  - Wound Healing/*physiology
RF  - 96
PMC - PMC3121784
EDAT- 2009/10/17 06:00
MHDA- 2010/04/22 06:00
CRDT- 2009/10/17 06:00
PHST- 2009/10/17 06:00 [entrez]
PHST- 2009/10/17 06:00 [pubmed]
PHST- 2010/04/22 06:00 [medline]
AID - 10.1089/ten.TEB.2009.0452 [doi]
PST - ppublish
SO  - Tissue Eng Part B Rev. 2010 Feb;16(1):105-15. doi: 10.1089/ten.TEB.2009.0452.


PMID- 19830592
OWN - NLM
STAT- MEDLINE
DCOM- 20100319
LR  - 20100106
IS  - 1572-8633 (Electronic)
IS  - 1386-7423 (Linking)
VI  - 13
IP  - 1
DP  - 2010 Feb
TI  - Conceptual analysis and empirical research in medical philosophy and medical
      ethics.
PG  - 1-2
LID - 10.1007/s11019-009-9225-8 [doi]
FAU - Dekkers, Wim
AU  - Dekkers W
FAU - Gordijn, Bert
AU  - Gordijn B
LA  - eng
PT  - Editorial
PT  - Introductory Journal Article
PL  - Netherlands
TA  - Med Health Care Philos
JT  - Medicine, health care, and philosophy
JID - 9815900
SB  - IM
MH  - *Empirical Research
MH  - *Ethics, Medical
MH  - Humans
MH  - *Philosophy, Medical
EDAT- 2009/10/16 06:00
MHDA- 2010/03/20 06:00
CRDT- 2009/10/16 06:00
PHST- 2009/10/16 06:00 [entrez]
PHST- 2009/10/16 06:00 [pubmed]
PHST- 2010/03/20 06:00 [medline]
AID - 10.1007/s11019-009-9225-8 [doi]
PST - ppublish
SO  - Med Health Care Philos. 2010 Feb;13(1):1-2. doi: 10.1007/s11019-009-9225-8.


PMID- 19828283
OWN - NLM
STAT- MEDLINE
DCOM- 20100420
LR  - 20220317
IS  - 1557-8615 (Electronic)
IS  - 0883-9441 (Linking)
VI  - 25
IP  - 1
DP  - 2010 Mar
TI  - Validity and reliability of the CAM-ICU Flowsheet to diagnose delirium in
      surgical ICU patients.
PG  - 144-51
LID - 10.1016/j.jcrc.2009.08.005 [doi]
AB  - PURPOSE: Delirium occurs frequently in critical care but often remains
      undiagnosed because delirium monitoring is often dismissed as being too
      time-consuming. This study determined the validity and reliability of the
      "CAM-ICU Flowsheet," a practical, time-sparing algorithm to assess the 4 delirium
      criteria in intubated patients. MATERIALS AND METHODS: With permission from our
      institution's ethics committee, patients of a 31-bed surgical intensive care unit
      department were screened for delirium (1) by a psychiatrist as the reference
      rater using the 4 delirium criteria of the Diagnostic and Statistical Manual of
      Mental Diseases, Fourth Edition (DSM-IV), and (2) by 2 physician investigators
      using a German translation of the CAM-ICU Flowsheet. RESULTS: Fifty-four surgical
      ICU patients underwent the complete protocol assessment with paired observations;
      46% were diagnosed with delirium by the reference rater (n = 25), 9% had
      hyperactive delirium (n = 5), and 37% were hypoactive (n = 20). The CAM-ICU
      Flowsheet investigators had sensitivities of 88% (95% confidence interval,
      69%-98%) and 92% (74%-99%), specificities of 100% (85%-100%), very high
      interrater reliability (kappa, 0.96; 0.87-1.00), and needed 50 seconds
      (interquartile range, 40-120 seconds) in patients with delirium vs 45 seconds
      (interquartile range, 40-75 seconds) in those without delirium to complete
      assessments. CONCLUSIONS: The CAM-ICU Flowsheet has high sensitivity, high
      specificity, and very high interrater reliability. False-negative ratings can
      occur infrequently and mostly reflect the fluctuating course of delirium. The
      CAM-ICU Flowsheet is a valid, reliable, and quickly performed bedside delirium
      instrument.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Guenther, Ulf
AU  - Guenther U
AD  - Klinik und Poliklinik fur Anasthesiologie und Operative Intensivmedizin,
      Universitatsklinikum Bonn, Germany. u.guenther@uni-bonn.de
FAU - Popp, Julius
AU  - Popp J
FAU - Koecher, Lena
AU  - Koecher L
FAU - Muders, Thomas
AU  - Muders T
FAU - Wrigge, Hermann
AU  - Wrigge H
FAU - Ely, E Wesley
AU  - Ely EW
FAU - Putensen, Christian
AU  - Putensen C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20091013
PL  - United States
TA  - J Crit Care
JT  - Journal of critical care
JID - 8610642
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - *Algorithms
MH  - Critical Care/*methods
MH  - Delirium/*diagnosis/epidemiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Psychiatric Status Rating Scales
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
EDAT- 2009/10/16 06:00
MHDA- 2010/04/21 06:00
CRDT- 2009/10/16 06:00
PHST- 2009/04/14 00:00 [received]
PHST- 2009/07/24 00:00 [revised]
PHST- 2009/08/10 00:00 [accepted]
PHST- 2009/10/16 06:00 [entrez]
PHST- 2009/10/16 06:00 [pubmed]
PHST- 2010/04/21 06:00 [medline]
AID - S0883-9441(09)00229-9 [pii]
AID - 10.1016/j.jcrc.2009.08.005 [doi]
PST - ppublish
SO  - J Crit Care. 2010 Mar;25(1):144-51. doi: 10.1016/j.jcrc.2009.08.005. Epub 2009
      Oct 13.


PMID- 19827966
OWN - NLM
STAT- MEDLINE
DCOM- 20100427
LR  - 20110825
IS  - 1557-7740 (Electronic)
IS  - 1557-7740 (Linking)
VI  - 13
IP  - 2
DP  - 2010 Feb
TI  - A study into the children's palliative care educational needs of health
      professionals in Uganda.
PG  - 147-53
LID - 10.1089/jpm.2009.0153 [doi]
AB  - STUDY AIM: To research the children's palliative care (CPC) educational needs of 
      health professionals in Uganda. METHODOLOGY DESIGN AND SETTING: Mixed
      quantitative and qualitative survey set in three hospice sites in Uganda.
      INTERVENTIONS: Self-rating survey, log book of problem cases, focus group of
      students of a CPC course. MAIN OUTCOME MEASURES: Self-rated "usefulness of
      further training" scores for CPC subject areas; thematic analysis of log books;
      thematic analysis of focus group findings. RESPONDENTS: All health professionals 
      (n = 50) were invited and 48 (96%) consented to participate. ETHICAL
      CONSIDERATIONS: The study was approved by the Hospice Africa Uganda (HAU)
      Research and Ethics Committee. RESULTS: Communication with children rated highest
      in all three arms of the study. SELF-RATING SURVEY: Average score = 8.3 of 10;
      range = 6.4 of 10 to 9.5 of 10. Communication with children, pain management, and
      psychological issues rated highest, and technical subject areas predominated. LOG
      BOOK ANALYSIS: Strongest themes were communicating with children and families,
      team-working, and managing personal stress. FOCUS GROUP ANALYSIS: Strongest
      themes were communicating with children, assessment and management planning, and 
      managing personal stress. DISCUSSION AND CONCLUSION: There is educational need
      for all CPC subject areas across the board, but communication with children is
      the most pressing. There are disparities between recognized learning needs
      (technical skills predominating) and unrecognized learning needs (interpersonal
      and intrapersonals skills predominating). While the broad subject areas for CPC
      may be similar in resource-rich and resource-poor settings, educational resources
      developed for the specific context of African and other resource poor settings
      are required.
FAU - Amery, Justin M
AU  - Amery JM
AD  - Hospice Africa Uganda, Kampala, Uganda. justin@amery.org
FAU - Rose, Caroline J
AU  - Rose CJ
FAU - Byarugaba, Charles
AU  - Byarugaba C
FAU - Agupio, Godfrey
AU  - Agupio G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Palliat Med
JT  - Journal of palliative medicine
JID - 9808462
SB  - IM
MH  - Child
MH  - Data Collection
MH  - Focus Groups
MH  - Health Personnel/*education
MH  - Health Services Needs and Demand
MH  - Humans
MH  - *Palliative Care
MH  - Uganda
EDAT- 2009/10/16 06:00
MHDA- 2010/04/28 06:00
CRDT- 2009/10/16 06:00
PHST- 2009/10/16 06:00 [entrez]
PHST- 2009/10/16 06:00 [pubmed]
PHST- 2010/04/28 06:00 [medline]
AID - 10.1089/jpm.2009.0153 [doi]
PST - ppublish
SO  - J Palliat Med. 2010 Feb;13(2):147-53. doi: 10.1089/jpm.2009.0153.


PMID- 19827965
OWN - NLM
STAT- MEDLINE
DCOM- 20100402
LR  - 20131121
IS  - 1557-7740 (Electronic)
IS  - 1557-7740 (Linking)
VI  - 13
IP  - 1
DP  - 2010 Jan
TI  - "Love your neighbor like yourself": a Jewish ethical approach to the use of pain 
      medication with potentially dangerous side effects.
PG  - 67-71
LID - 10.1089/jpm.2009.0182 [doi]
AB  - Palliation of pain is universally regarded as a cardinal aspect of end-of-life
      care. In the early days of the palliative care and hospice movement there was
      concern that aggressive pain control with opioids could potentially hasten the
      death of the patient primarily through respiratory depression. For many ethicists
      and theologians who were opposed to active euthanasia, this raised the difficult 
      question of whether it is permissible to use these potentially harmful
      medications. Traditional Jewish decisors also addressed this question and their
      writings can shed light on their attitudes toward terminal care. The purpose of
      this article is to analyze the view of three highly respected authorities on the 
      use of pain medications with potentially significant side effects in terminal
      patients. The Jewish position demonstrates how an ancient tradition struggles to 
      develop an ethic consistent with modern sensibilities. Religious decisors scour
      the ancient sources to find precedents and then apply that wisdom to contemporary
      questions. Jewish medical ethics by its very nature is highly pluralistic because
      there is no central body that determines policy and a wide spectrum of opinions
      are usually found. However, regarding pain treatment there appears to be a broad 
      consensus mandating its aggressive use even at the risk of significant side
      effects as long as the motivation is relief of suffering.
FAU - Jotkowitz, Alan
AU  - Jotkowitz A
AD  - Faculty of Health Sciences, Ben-Gurion University of the Negev, The Jakobovits
      Center for Jewish Medical Ethics, Beer-Sheva, Israel.
FAU - Zivotofsky, Ari Z
AU  - Zivotofsky AZ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Palliat Med
JT  - Journal of palliative medicine
JID - 9808462
RN  - 0 (Analgesics)
SB  - IM
MH  - *Altruism
MH  - Analgesics/*adverse effects/therapeutic use
MH  - *Attitude
MH  - Drug Therapy/*ethics
MH  - Drug-Related Side Effects and Adverse Reactions
MH  - Humans
MH  - *Judaism
MH  - Palliative Care/ethics
MH  - Religion and Medicine
MH  - Terminal Care/ethics
EDAT- 2009/10/16 06:00
MHDA- 2010/04/03 06:00
CRDT- 2009/10/16 06:00
PHST- 2009/10/16 06:00 [entrez]
PHST- 2009/10/16 06:00 [pubmed]
PHST- 2010/04/03 06:00 [medline]
AID - 10.1089/jpm.2009.0182 [doi]
PST - ppublish
SO  - J Palliat Med. 2010 Jan;13(1):67-71. doi: 10.1089/jpm.2009.0182.


PMID- 19826451
OWN - NLM
STAT- MEDLINE
DCOM- 20100518
LR  - 20211203
IS  - 1476-5438 (Electronic)
IS  - 1018-4813 (Linking)
VI  - 18
IP  - 3
DP  - 2010 Mar
TI  - Comparison of participant information and informed consent forms of five European
      studies in genetic isolated populations.
PG  - 296-302
LID - 10.1038/ejhg.2009.155 [doi]
AB  - Family-based research in genetically isolated populations is an effective
      approach for identifying loci influencing variation in disease traits. In common 
      with all studies in humans, those in genetically isolated populations need
      ethical approval; however, existing ethical frameworks may be inadequate to
      protect participant privacy and confidentiality and to address participants'
      information needs in such populations. Using the ethical-legal guidelines of the 
      Council for International Organizations of Medical Sciences (CIOMS) as a
      template, we compared the participant information leaflets and consent forms of
      studies in five European genetically isolated populations to identify additional 
      information that should be incorporated into information leaflets and consent
      forms to guarantee satisfactorily informed consent. We highlight the additional
      information that participants require on the research purpose and the reasons why
      their population was chosen; on the potential risks and benefits of
      participation; on the opportunities for benefit sharing; on privacy; on the
      withdrawal of consent and on the disclosure of genetic data. This research raises
      some important issues that should be addressed properly and identifies relevant
      types of information that should be incorporated into information leaflets for
      this type of study.
FAU - Mascalzoni, Deborah
AU  - Mascalzoni D
AD  - Institute of Genetic Medicine, European Academy Bozen/Bolzano (EURAC), Bolzano,
      Italy. deborah.mascalzoni@eurac.edu
FAU - Janssens, A Cecile J W
AU  - Janssens AC
FAU - Stewart, Alison
AU  - Stewart A
FAU - Pramstaller, Peter
AU  - Pramstaller P
FAU - Gyllensten, Ulf
AU  - Gyllensten U
FAU - Rudan, Igor
AU  - Rudan I
FAU - van Duijn, Cornelia M
AU  - van Duijn CM
FAU - Wilson, James F
AU  - Wilson JF
FAU - Campbell, Harry
AU  - Campbell H
FAU - Quillan, Ruth M C
AU  - Quillan RM
CN  - EUROSPAN consortium
LA  - eng
GR  - CZB/4/710/CSO_/Chief Scientist Office/United Kingdom
PT  - Comparative Study
PT  - Journal Article
DEP - 20091014
PL  - England
TA  - Eur J Hum Genet
JT  - European journal of human genetics : EJHG
JID - 9302235
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Consent Forms/*ethics
MH  - Ethnicity/*genetics/*legislation & jurisprudence
MH  - Europe
MH  - Humans
MH  - Middle Aged
MH  - Patient Participation/*legislation & jurisprudence
MH  - Patient Selection/ethics
MH  - Practice Guidelines as Topic
MH  - Societies, Medical
MH  - Young Adult
PMC - PMC2987217
EDAT- 2009/10/15 06:00
MHDA- 2010/05/19 06:00
CRDT- 2009/10/15 06:00
PHST- 2009/10/15 06:00 [entrez]
PHST- 2009/10/15 06:00 [pubmed]
PHST- 2010/05/19 06:00 [medline]
AID - ejhg2009155 [pii]
AID - 10.1038/ejhg.2009.155 [doi]
PST - ppublish
SO  - Eur J Hum Genet. 2010 Mar;18(3):296-302. doi: 10.1038/ejhg.2009.155. Epub 2009
      Oct 14.


PMID- 19822227
OWN - NLM
STAT- MEDLINE
DCOM- 20100518
LR  - 20100215
IS  - 1743-9159 (Electronic)
IS  - 1743-9159 (Linking)
VI  - 8
IP  - 1
DP  - 2010
TI  - A bleeding controversy: duties and decisions in the face of conflicting advice.
PG  - 32-4
LID - 10.1016/j.ijsu.2009.10.002 [doi]
AB  - The authors use a composite case based on their experiences to illustrate the
      ethics of inter-professional conflict. An HDU team receive two telephone calls.
      One is from the patient's cardiologist, who states that a patient must be
      anti-coagulated without delay. The other is from the surgeon responsible for the 
      patient's current admission, who states that the patient must under no
      circumstances be anti-coagulated. We argue that in the absence of a broad
      understanding of the patient's condition and values, specialists should be
      cautious when giving categorical orders or, at the very least, should provide the
      rationale for their advice to help the care leader in his or her decision-making.
CI  - Copyright 2009 Surgical Associates Ltd. Published by Elsevier Ltd. All rights
      reserved.
FAU - Bahal, Nawal
AU  - Bahal N
AD  - Specialist Registrar in Anaesthetics, Oxford Deanery, UK.
FAU - Papanikitas, Andrew
AU  - Papanikitas A
FAU - Sokol, Daniel K
AU  - Sokol DK
LA  - eng
PT  - Journal Article
DEP - 20091012
PL  - England
TA  - Int J Surg
JT  - International journal of surgery (London, England)
JID - 101228232
RN  - 0 (Anticoagulants)
SB  - IM
MH  - Anticoagulants/*administration & dosage
MH  - Cardiology/ethics
MH  - Clinical Competence/*standards
MH  - *Decision Making
MH  - Ethics, Medical
MH  - General Surgery/ethics
MH  - Hemorrhage/etiology/prevention & control
MH  - Hernia, Inguinal/surgery
MH  - Humans
MH  - *Interprofessional Relations
MH  - Medical Staff, Hospital/*standards
MH  - Postoperative Complications/etiology/prevention & control
MH  - Risk Assessment
MH  - Stroke/prevention & control
MH  - Withholding Treatment
EDAT- 2009/10/14 06:00
MHDA- 2010/05/19 06:00
CRDT- 2009/10/14 06:00
PHST- 2009/07/19 00:00 [received]
PHST- 2009/09/03 00:00 [revised]
PHST- 2009/10/05 00:00 [accepted]
PHST- 2009/10/14 06:00 [entrez]
PHST- 2009/10/14 06:00 [pubmed]
PHST- 2010/05/19 06:00 [medline]
AID - S1743-9191(09)00145-9 [pii]
AID - 10.1016/j.ijsu.2009.10.002 [doi]
PST - ppublish
SO  - Int J Surg. 2010;8(1):32-4. doi: 10.1016/j.ijsu.2009.10.002. Epub 2009 Oct 12.


PMID- 19821060
OWN - NLM
STAT- MEDLINE
DCOM- 20110210
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 16
IP  - 3
DP  - 2010 Sep
TI  - Katrina: macro-ethical issues for engineers.
PG  - 535-71
LID - 10.1007/s11948-009-9167-9 [doi]
AB  - Hurricane Katrina was one of the worst disasters in United States history.
      Failures within New Orleans' engineered hurricane protection system (levees and
      floodwalls) contributed to the severity of the event and have drawn considerable 
      public attention. In the time since Katrina, forensic investigations have
      uncovered a range of issues and problems related to the engineering work. In this
      article, my goal is to distill from these investigations, and the related
      literature that has accumulated, some overarching macro-ethical issues that are
      relevant for all engineers. I attempt to frame these issues, using illustrative
      examples taken from Katrina, in a way that might be of pedagogical use and
      benefit for engineering educators interested in engaging their students in
      discussions of engineering ethics, societal impact of engineered systems,
      engineering design, or related topics. Some of the issues discussed are problems 
      of unanticipated failure modes, faulty assumptions, lack or misuse of
      information, the importance of resiliency, the effects of time, balancing
      competing interests, attending to the details of interfaces, the fickleness of
      risk perception, and how the past constrains the present.
FAU - Newberry, Byron
AU  - Newberry B
AD  - Department of Mechanical Engineering, Baylor University, Bear Waco, TX 76798,
      USA. Byron_Newberry@Baylor.edu
LA  - eng
PT  - Journal Article
DEP - 20091010
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Cyclonic Storms
MH  - Disasters
MH  - Engineering/*ethics/methods/standards
MH  - Equipment Failure Analysis
MH  - *Ethics, Professional/education
MH  - New Orleans
MH  - Teaching
EDAT- 2009/10/13 06:00
MHDA- 2011/02/11 06:00
CRDT- 2009/10/13 06:00
PHST- 2009/08/01 00:00 [received]
PHST- 2009/09/01 00:00 [accepted]
PHST- 2009/10/13 06:00 [entrez]
PHST- 2009/10/13 06:00 [pubmed]
PHST- 2011/02/11 06:00 [medline]
AID - 10.1007/s11948-009-9167-9 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2010 Sep;16(3):535-71. doi: 10.1007/s11948-009-9167-9. Epub 2009 
      Oct 10.


PMID- 19820044
OWN - NLM
STAT- MEDLINE
DCOM- 20100409
LR  - 20141120
IS  - 1525-3163 (Electronic)
IS  - 0021-8812 (Linking)
VI  - 88
IP  - 2
DP  - 2010 Feb
TI  - Trait selection and welfare of genetically engineered animals in agriculture.
PG  - 811-4
LID - 10.2527/jas.2009-2043 [doi]
AB  - The release of the Final Guidance from the US Food and Drug Administration on the
      commercialization of genetically engineered animals has sparked renewed
      discussion over the ethical, consumer, and regulatory implications of
      transgenesis in animal agriculture. Animal welfare critiques have focused on
      unexpected phenotypic effects in animals used in transgenic research, rather than
      on the health and welfare implications of the intended productivity enhancement. 
      Unless breeding goals are redefined to reflect social concerns, the occurrence
      and magnitude of undesirable side effects may increase and consumer confidence in
      the nascent technology may be undermined.
FAU - Greger, M
AU  - Greger M
AD  - Humane Society of the United States, 2100 L. St. N.W., Washington, DC 20037, USA.
      mhg1@cornell.edu
LA  - eng
PT  - Journal Article
DEP - 20091009
PL  - United States
TA  - J Anim Sci
JT  - Journal of animal science
JID - 8003002
SB  - IM
MH  - Animal Husbandry/ethics/methods
MH  - Animal Welfare/ethics
MH  - Animals
MH  - Animals, Domestic/*genetics
MH  - Animals, Genetically Modified/*genetics
MH  - Consumer Behavior
MH  - *Quantitative Trait, Heritable
MH  - United States
EDAT- 2009/10/13 06:00
MHDA- 2010/04/10 06:00
CRDT- 2009/10/13 06:00
PHST- 2009/10/13 06:00 [entrez]
PHST- 2009/10/13 06:00 [pubmed]
PHST- 2010/04/10 06:00 [medline]
AID - jas.2009-2043 [pii]
AID - 10.2527/jas.2009-2043 [doi]
PST - ppublish
SO  - J Anim Sci. 2010 Feb;88(2):811-4. doi: 10.2527/jas.2009-2043. Epub 2009 Oct 9.


PMID- 19819449
OWN - NLM
STAT- MEDLINE
DCOM- 20100603
LR  - 20220316
IS  - 1873-491X (Electronic)
IS  - 0020-7489 (Linking)
VI  - 47
IP  - 4
DP  - 2010 Apr
TI  - Maternal return to work and breastfeeding: a population-based cohort study.
PG  - 461-74
LID - 10.1016/j.ijnurstu.2009.09.003 [doi]
AB  - BACKGROUND: In recent decades there has been a marked rise in the participation
      of women with infants in the labour market, while there has been a decline in the
      prevalence rate of breastfeeding. OBJECTIVE: To explore the relationship between 
      maternal return to work and breastfeeding. DESIGN: An on-going prospective
      longitudinal study. SETTING AND PARTICIPANTS: Multistage stratified systematic
      sampling was designed to recruit 24,200 pairs, postpartum women and newborns,
      from the Taiwan national birth register in 2005. Participating women underwent
      two home interviews at 6 and 18 months after giving birth, following structured
      questionnaires. A total of 21,248 and 20,172 women were interviewed, and the
      completed interview rate was thus 87.8% and 83.4% at 6 and 18 months,
      respectively. All study participants provided informed consent as approved by the
      Ethics Review Board of the National Taiwan College of Public Health. RESULTS: The
      overall prevalence of initial breastfeeding was 83.7%. Postpartum women returning
      to work less than or equal to 1 month had the lowest initiation of breastfeeding 
      rate (77.5%), but had a higher prevalence of breastfeeding duration less than or 
      equal to 1 month (34.9%) than the overall population (26.8%). Overall 67.9%,
      39.4%, 25.4%, and 12.7% mothers who started breastfeeding still breastfed their
      infants at the age of 1, 3, 6 and 12 months, respectively. Women with maternal
      leave of less than or equal to 6 months ceased breastfeeding earlier than those
      with maternal leave beyond 6 months and those who did not return to work up to 18
      months after birth. After adjustment for potential confounders, odds ratios of
      initial breastfeeding seemed no different, except those for postpartum women who 
      returned to work less than or equal to 1 month and those who did not return to
      work. Mothers returning to work within 1 year after giving birth were
      significantly earlier in weaning than those without return to work. CONCLUSION:
      In our study, an early maternal return to work, especial within 6 months after
      giving birth, was a barrier to the initiation and continuation of breastfeeding. 
      Thus, a comprehensive strategy is required to encourage the practice of
      breastfeeding in working women from pregnancy to the return to work, and nurses
      should work to promote breastfeeding in the different occasion.
CI  - Copyright 2009 Elsevier Ltd. All rights reserved.
FAU - Chuang, Chao-Hua
AU  - Chuang CH
AD  - Department of Nursing, Chang Jung Christian University, Tainan County 71101,
      Taiwan. chchuang@mail.cjcu.edu.tw
FAU - Chang, Pei-Jen
AU  - Chang PJ
FAU - Chen, Yi-Chun
AU  - Chen YC
FAU - Hsieh, Wu-Shiun
AU  - Hsieh WS
FAU - Hurng, Baai-Shyun
AU  - Hurng BS
FAU - Lin, Shio-Jean
AU  - Lin SJ
FAU - Chen, Pau-Chung
AU  - Chen PC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091012
PL  - England
TA  - Int J Nurs Stud
JT  - International journal of nursing studies
JID - 0400675
SB  - IM
MH  - *Breast Feeding
MH  - Cohort Studies
MH  - *Employment
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - *Mothers
MH  - Pregnancy
MH  - Prospective Studies
MH  - Surveys and Questionnaires
MH  - Taiwan
EDAT- 2009/10/13 06:00
MHDA- 2010/06/04 06:00
CRDT- 2009/10/13 06:00
PHST- 2009/04/10 00:00 [received]
PHST- 2009/08/14 00:00 [revised]
PHST- 2009/09/06 00:00 [accepted]
PHST- 2009/10/13 06:00 [entrez]
PHST- 2009/10/13 06:00 [pubmed]
PHST- 2010/06/04 06:00 [medline]
AID - S0020-7489(09)00310-1 [pii]
AID - 10.1016/j.ijnurstu.2009.09.003 [doi]
PST - ppublish
SO  - Int J Nurs Stud. 2010 Apr;47(4):461-74. doi: 10.1016/j.ijnurstu.2009.09.003. Epub
      2009 Oct 12.


PMID- 19818687
OWN - NLM
STAT- MEDLINE
DCOM- 20100907
LR  - 20190429
IS  - 1873-5223 (Electronic)
IS  - 1471-5953 (Linking)
VI  - 10
IP  - 4
DP  - 2010 Jul
TI  - The essence of professional competence experienced by Norwegian nurse students: a
      phenomenological study.
PG  - 183-8
LID - 10.1016/j.nepr.2009.08.003 [doi]
AB  - This paper reports a study, which explored the lived experiences of the essence
      in developing nursing students' professional competence. Nursing students
      experience a high level of stress due to unexpected, uncontrolled and uncertain
      aspects in the clinical learning environment. A purposeful sampling technique was
      used to select 18 participants from all second year students. Focus group
      interviews were conducted for collection of data. The data was analyzed by
      applying the Giorgi method of analyzing phenomenological data. Experience of
      responsibility is central to professional development. A secure relation with
      nurse consultants is the basis for learning. Students wish to see contexts and
      reach a holistic understanding. Continuous guidance as well as students'
      continuous supervision of patients is vital for understanding the larger context 
      of care. Educators and professional nurses with supervision responsibility must
      display the knowledge and skills required to promote the development of nursing
      students' professional competence. This study also highlights the importance of
      the ethical dimension inherent in the concept of competence. Group supervision
      can offer an opportunity for students to address their experiences of their
      ability to deal with unfamiliar and existential demands of practice. These
      fundamental presuppositions comprise collective requirements for education and
      competence development in practice.
CI  - Copyright 2009 Elsevier Ltd. All rights reserved.
FAU - Thorkildsen, Kari
AU  - Thorkildsen K
AD  - Stord/Haugesund University College, Department of Health Care Studies, Norway.
FAU - Raholm, Maj-Britt
AU  - Raholm MB
LA  - eng
PT  - Journal Article
DEP - 20091008
PL  - Scotland
TA  - Nurse Educ Pract
JT  - Nurse education in practice
JID - 101090848
SB  - IM
MH  - Competency-Based Education/methods/standards
MH  - Education, Nursing/methods/*standards
MH  - Faculty, Nursing
MH  - Focus Groups
MH  - Humans
MH  - Interpersonal Relations
MH  - Norway
MH  - Professional Competence/*standards
MH  - Stress, Psychological
MH  - Students, Nursing/*psychology
EDAT- 2009/10/13 06:00
MHDA- 2010/09/08 06:00
CRDT- 2009/10/13 06:00
PHST- 2008/09/01 00:00 [received]
PHST- 2009/07/20 00:00 [revised]
PHST- 2009/08/31 00:00 [accepted]
PHST- 2009/10/13 06:00 [entrez]
PHST- 2009/10/13 06:00 [pubmed]
PHST- 2010/09/08 06:00 [medline]
AID - S1471-5953(09)00145-0 [pii]
AID - 10.1016/j.nepr.2009.08.003 [doi]
PST - ppublish
SO  - Nurse Educ Pract. 2010 Jul;10(4):183-8. doi: 10.1016/j.nepr.2009.08.003. Epub
      2009 Oct 8.


PMID- 19815622
OWN - NLM
STAT- MEDLINE
DCOM- 20100308
LR  - 20220408
IS  - 1460-2350 (Electronic)
IS  - 0268-1161 (Linking)
VI  - 25
IP  - 1
DP  - 2010 Jan
TI  - Embryonic stem cell-like cells derived from adult human testis.
PG  - 158-67
LID - 10.1093/humrep/dep354 [doi]
AB  - BACKGROUND: Given the significant drawbacks of using human embryonic stem (hES)
      cells for regenerative medicine, the search for alternative sources of
      multipotent cells is ongoing. Studies in mice have shown that multipotent ES-like
      cells can be derived from neonatal and adult testis. Here we report the
      derivation of ES-like cells from adult human testis. METHODS: Testis material was
      donated for research by four men undergoing bilateral castration as part of
      prostate cancer treatment. Testicular cells were cultured using StemPro medium.
      Colonies that appeared sharp edged and compact were collected and subcultured
      under hES-specific conditions. Molecular characterization of these colonies was
      performed using RT-PCR and immunohistochemistry. (Epi)genetic stability was
      tested using bisulphite sequencing and karyotype analysis. Directed
      differentiation protocols in vitro were performed to investigate the potency of
      these cells and the cells were injected into immunocompromised mice to
      investigate their tumorigenicity. RESULTS: In testicular cell cultures from all
      four men, sharp-edged and compact colonies appeared between 3 and 8 weeks.
      Subcultured cells from these colonies showed alkaline phosphatase activity and
      expressed hES cell-specific genes (Pou5f1, Sox2, Cripto1, Dnmt3b), proteins and
      carbohydrate antigens (POU5F1, NANOG, SOX2 and TRA-1-60, TRA-1-81, SSEA4). These 
      ES-like cells were able to differentiate in vitro into derivatives of all three
      germ layers including neural, epithelial, osteogenic, myogenic, adipocyte and
      pancreatic lineages. The pancreatic beta cells were able to produce insulin in
      response to glucose and osteogenic-differentiated cells showed deposition of
      phosphate and calcium, demonstrating their functional capacity. Although we
      observed small areas with differentiated cell types of human origin, we never
      observed extensive teratomas upon injection of testis-derived ES-like cells into 
      immunocompromised mice. CONCLUSIONS: Multipotent cells can be established from
      adult human testis. Their easy accessibility and ethical acceptability as well as
      their non-tumorigenic and autogenic nature make these cells an attractive
      alternative to human ES cells for future stem cell therapies.
FAU - Mizrak, S C
AU  - Mizrak SC
AD  - Center for Reproductive Medicine, Department of Obstetrics and Gynecology,
      Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105, AZ
      Amsterdam, The Netherlands. S.C.Mizrak@amc.uva.nl
FAU - Chikhovskaya, J V
AU  - Chikhovskaya JV
FAU - Sadri-Ardekani, H
AU  - Sadri-Ardekani H
FAU - van Daalen, S
AU  - van Daalen S
FAU - Korver, C M
AU  - Korver CM
FAU - Hovingh, S E
AU  - Hovingh SE
FAU - Roepers-Gajadien, H L
AU  - Roepers-Gajadien HL
FAU - Raya, A
AU  - Raya A
FAU - Fluiter, K
AU  - Fluiter K
FAU - de Reijke, Th M
AU  - de Reijke TM
FAU - de la Rosette, J J M C H
AU  - de la Rosette JJ
FAU - Knegt, A C
AU  - Knegt AC
FAU - Belmonte, J C
AU  - Belmonte JC
FAU - van der Veen, F
AU  - van der Veen F
FAU - de Rooij, D G
AU  - de Rooij DG
FAU - Repping, S
AU  - Repping S
FAU - van Pelt, A M M
AU  - van Pelt AM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091008
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Animals
MH  - *Cell Culture Techniques
MH  - Cell Differentiation
MH  - Cell Proliferation
MH  - Embryonic Stem Cells/*cytology/metabolism
MH  - Humans
MH  - Karyotyping
MH  - Male
MH  - Mice
MH  - Middle Aged
MH  - Multipotent Stem Cells/*cytology/metabolism
MH  - Testis/*cytology
EDAT- 2009/10/10 06:00
MHDA- 2010/03/10 06:00
CRDT- 2009/10/10 06:00
PHST- 2009/10/10 06:00 [entrez]
PHST- 2009/10/10 06:00 [pubmed]
PHST- 2010/03/10 06:00 [medline]
AID - dep354 [pii]
AID - 10.1093/humrep/dep354 [doi]
PST - ppublish
SO  - Hum Reprod. 2010 Jan;25(1):158-67. doi: 10.1093/humrep/dep354. Epub 2009 Oct 8.


PMID- 19813094
OWN - NLM
STAT- MEDLINE
DCOM- 20111130
LR  - 20211020
IS  - 1573-3394 (Electronic)
IS  - 1065-3058 (Linking)
VI  - 18
IP  - 3
DP  - 2010 Sep
TI  - Ethical aspects of the use of stem cell derived gametes for reproduction.
PG  - 267-78
LID - 10.1007/s10728-009-0136-x [doi]
AB  - A lot of interest has been generated by the possibility of deriving gametes from 
      embryonic stem cells and bone marrow stem cells. These stem cell derived gametes 
      may become useful for research and for the treatment of infertility. In this
      article we consider prospectively the ethical issues that will arise if stem cell
      derived gametes are used in the clinic, making a distinction between concerns
      that only apply to embryonic stem cell derived gametes and concerns that are also
      relevant for gametes derived from adult stem cells. At present, it appears
      preferable to use non-embryonic stem cells for the derivation of gametes. Adult
      stem cell derived gametes do not present any problems with regard to the moral
      status of the human embryo, bypass the safety risks linked to SCNT and do not
      present any ambiguity or novel problems with regard to informed consent,
      psychological consequences for the child or genetic parenthood. A remaining
      ethical concern, however, regards the safety of the procedure in terms of the
      welfare of the resulting children. This should spark a thorough reflection on how
      far one must go to accommodate a person's wish to have a genetically related
      child.
FAU - Mertes, Heidi
AU  - Mertes H
AD  - Bioethics Institute Ghent, Ghent University, Ghent, Belgium.
      Heidi.Mertes@UGent.be
FAU - Pennings, Guido
AU  - Pennings G
LA  - eng
PT  - Journal Article
DEP - 20091007
PL  - Netherlands
TA  - Health Care Anal
JT  - Health care analysis : HCA : journal of health philosophy and policy
JID - 9432537
MH  - Adult
MH  - *Adult Stem Cells
MH  - Bioethical Issues
MH  - Child
MH  - *Embryonic Stem Cells
MH  - *Germ Cells
MH  - Humans
MH  - Parents/psychology
MH  - Prospective Studies
MH  - Reproductive Techniques, Assisted/*ethics
MH  - Stem Cell Research/*ethics
EDAT- 2009/10/09 06:00
MHDA- 2011/12/13 00:00
CRDT- 2009/10/09 06:00
PHST- 2009/06/23 00:00 [received]
PHST- 2009/08/13 00:00 [accepted]
PHST- 2009/10/09 06:00 [entrez]
PHST- 2009/10/09 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/s10728-009-0136-x [doi]
PST - ppublish
SO  - Health Care Anal. 2010 Sep;18(3):267-78. doi: 10.1007/s10728-009-0136-x. Epub
      2009 Oct 7.


PMID- 19811511
OWN - NLM
STAT- MEDLINE
DCOM- 20100330
LR  - 20220409
IS  - 1600-9657 (Electronic)
IS  - 1600-4469 (Linking)
VI  - 26
IP  - 1
DP  - 2010 Feb
TI  - Contradictions in the treatment of traumatic dental injuries and ways to proceed 
      in dental trauma research.
PG  - 16-22
LID - 10.1111/j.1600-9657.2009.00818.x [doi]
AB  - Almost all treatment procedures used for dental traumas are still today not
      evidence-based, a fact, which makes it difficult to analyse the long-term outcome
      of healing and its relationship to treatment. Crown fractures with extensive
      dentin exposure represent a dominant injury in the permanent dentition. Accepted 
      treatment philosophy is dentin coverage (dental liner and/or dentin bonded
      restoration) to prevent bacteria penetration into the pulp. Today there is, apart
      from deep proximal fractures, no evidence that this treatment is necessary to
      protect the pulp. In case of luxation injuries, the accepted treatment principles
      appear to be anatomically correct repositioning, stabilization with a splint and 
      sometimes antibiotic coverage. In clinical studies, these principles could not be
      proven to optimize either periodontal or pulpal healing, the explanation possibly
      being that both reposition and application of splints in certain cases add extra 
      damage to the pulp and periodontal ligament. In case of root fractures with
      dislocation, fast and optimal repositioning and rigid long-term splinting (i.e. 3
      months) have been considered the principle of treatment. However, a recent
      clinical study has shown that short-term splinting with a semi-rigid splint
      appears to optimize fracture healing. In tooth avulsion with subsequent
      replantation, cleansing of the root surface for contamination and systemic
      antibiotics has been considered essential for pulp and periodontal healing. These
      treatment concepts have been derived from experimental studies in animals.
      However, their importance could not be verified in large clinical studies.
      Ideally, randomized clinical studies are needed in the future for selected trauma
      types. The influences of repositioning, splinting and the role of infection and
      antibiotics should be further investigated. However, for ethical reasons, it will
      be difficult to perform randomized studies on trauma victims and we will be
      forced in the future to rely on experimental animal studies supported by clinical
      observational studies.
FAU - Andreasen, Jens Ove
AU  - Andreasen JO
AD  - Department of Oral and Maxillofacial Surgery, Copenhagen University Hospital,
      Copenhagen, Denmark. jens.ove.andreasen@rh.regionh.dk
FAU - Lauridsen, Eva
AU  - Lauridsen E
FAU - Andreasen, Frances Meriam
AU  - Andreasen FM
LA  - eng
PT  - Journal Article
DEP - 20091007
PL  - Denmark
TA  - Dent Traumatol
JT  - Dental traumatology : official publication of International Association for
      Dental Traumatology
JID - 101091305
MH  - Cognitive Dissonance
MH  - Dental Leakage/prevention & control
MH  - Dental Pulp Exposure/prevention & control
MH  - Evidence-Based Dentistry
MH  - Humans
MH  - Periodontal Splints
MH  - Tooth Avulsion/*therapy
MH  - Tooth Fractures/*therapy
MH  - Tooth Replantation
EDAT- 2009/10/09 06:00
MHDA- 2010/03/31 06:00
CRDT- 2009/10/09 06:00
PHST- 2009/10/09 06:00 [entrez]
PHST- 2009/10/09 06:00 [pubmed]
PHST- 2010/03/31 06:00 [medline]
AID - EDT818 [pii]
AID - 10.1111/j.1600-9657.2009.00818.x [doi]
PST - ppublish
SO  - Dent Traumatol. 2010 Feb;26(1):16-22. doi: 10.1111/j.1600-9657.2009.00818.x. Epub
      2009 Oct 7.


PMID- 19809329
OWN - NLM
STAT- MEDLINE
DCOM- 20100222
LR  - 20131121
IS  - 1365-2346 (Electronic)
IS  - 0265-0215 (Linking)
VI  - 27
IP  - 1
DP  - 2010 Jan
TI  - Intramuscular injection of malignant hyperthermia trigger agents induces
      hypermetabolism in susceptible and nonsusceptible individuals.
PG  - 77-82
LID - 10.1097/EJA.0b013e32832b7609 [doi]
AB  - BACKGROUND AND OBJECTIVE: A new minimally invasive metabolic test for the
      diagnosis of susceptibility for malignant hyperthermia measuring intramuscular
      p(CO(2)) and lactate following local application of caffeine and halothane in
      humans was recently proposed. The present study tested the hypothesis that a more
      simplified test protocol allows a differentiation between malignant hyperthermia 
      susceptible (MHS) and malignant hyperthermia nonsusceptible (MHN) and control
      individuals. METHODS: With approval of the local ethics committee and informed
      consent, microdialysis and p(CO(2)) probes with attached microtubing were placed 
      into the lateral vastus muscle of six MHS, seven MHN and seven control
      individuals. Following equilibration, boluses of 500 microl caffeine 80 mmol
      l(-1) and halothane 10 vol% dissolved in soybean oil were injected locally.
      p(CO(2)) and lactate were measured spectrophotometrically. RESULTS: The maximal
      rate of p(CO(2)) increase was significantly higher in MHS than in MHN and control
      individuals following application of halothane and caffeine, respectively.
      Intramuscular caffeine injection leads to a significantly higher increase of
      local lactate levels in MHS than in MHN and control individuals, whereas
      halothane increased local lactate levels in all investigated groups. Haemodynamic
      and systemic metabolic parameters did not differ between the investigated groups.
      CONCLUSION: Local caffeine and halothane injection increased intramuscular
      metabolism in MHS individuals significantly more than in the two other groups. In
      contrast to previous investigations, direct injection of the concentrations of
      halothane described here increased lactate and p(CO(2)) even in MHN skeletal
      muscle.
FAU - Metterlein, Thomas
AU  - Metterlein T
AD  - Department of Anesthesiology, University of Wurzburg, Wurzburg, Germany.
      metterlein_t@mail.klinik.uni-wuerzburg.de
FAU - Schuster, Frank
AU  - Schuster F
FAU - Kranke, Peter
AU  - Kranke P
FAU - Roewer, Norbert
AU  - Roewer N
FAU - Anetseder, Martin
AU  - Anetseder M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur J Anaesthesiol
JT  - European journal of anaesthesiology
JID - 8411711
RN  - 0 (Lactates)
RN  - 142M471B3J (Carbon Dioxide)
RN  - 3G6A5W338E (Caffeine)
RN  - 8001-22-7 (Soybean Oil)
RN  - S88TT14065 (Oxygen)
RN  - UQT9G45D1P (Halothane)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Caffeine/*adverse effects
MH  - Carbon Dioxide/chemistry
MH  - Female
MH  - Halothane/*adverse effects
MH  - Humans
MH  - Injections, Intramuscular/*methods
MH  - Lactates/metabolism
MH  - Male
MH  - Malignant Hyperthermia/*diagnosis/etiology/*metabolism
MH  - Middle Aged
MH  - Muscle, Skeletal/drug effects
MH  - Oxygen/chemistry
MH  - Soybean Oil
EDAT- 2009/10/08 06:00
MHDA- 2010/02/23 06:00
CRDT- 2009/10/08 06:00
PHST- 2009/10/08 06:00 [entrez]
PHST- 2009/10/08 06:00 [pubmed]
PHST- 2010/02/23 06:00 [medline]
AID - 10.1097/EJA.0b013e32832b7609 [doi]
PST - ppublish
SO  - Eur J Anaesthesiol. 2010 Jan;27(1):77-82. doi: 10.1097/EJA.0b013e32832b7609.


PMID- 19807661
OWN - NLM
STAT- MEDLINE
DCOM- 20100901
LR  - 20191111
IS  - 2212-3946 (Electronic)
IS  - 1574-888X (Linking)
VI  - 5
IP  - 1
DP  - 2010 Mar
TI  - Applications of human umbilical cord blood cells in central nervous system
      regeneration.
PG  - 17-22
AB  - In recent decades, there has been considerable amount of information about
      embryonic stem cells (ES). The dilemma facing scientists interested in the
      development and use of human stem cells in replacement therapies is the source of
      these cells, i.e. the human embryo. There are many ethical and moral problems
      related to the use of these cells. Hematopoietic stem cells from umbilical cord
      blood have been proposed as an alternative source of embryonic stem cells. After 
      exposure to different agents, these cells are able to express antigens of diverse
      cellular lineages, including the neural type. The In vitro manipulation of human 
      umbilical cord blood (hUCB) cells has shown their stem capacity and plasticity.
      These cells are easily accessible, In vitro amplifiable, well tolerated by the
      host, and with more primitive molecular characteristics that give them great
      flexibility. Overall, these properties open a promising future for the use of
      hUCB in regenerative therapies for the Central Nervous System (CNS). This review 
      will focus on the available literature concerning umbilical cord blood cells as a
      therapeutic tool for the treatment of neurodegenerative diseases.
FAU - Herranz, Antonio S
AU  - Herranz AS
AD  - Servicio Neurobiologia-Investigacion, Laboratorio Neurobiologia Celulas Madre,
      Hospital Ramon y Cajal - SERMAS, 28034 Madrid, Spain. antonio.sanchez@hrc.es
FAU - Gonzalo-Gobernado, Rafael
AU  - Gonzalo-Gobernado R
FAU - Reimers, Diana
AU  - Reimers D
FAU - Asensio, Maria J
AU  - Asensio MJ
FAU - Rodriguez-Serrano, Macarena
AU  - Rodriguez-Serrano M
FAU - Bazan, Eulalia
AU  - Bazan E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Curr Stem Cell Res Ther
JT  - Current stem cell research & therapy
JID - 101272517
SB  - IM
MH  - Animals
MH  - Cell Differentiation
MH  - Central Nervous System/*metabolism/pathology
MH  - *Cord Blood Stem Cell Transplantation
MH  - Embryonic Stem Cells
MH  - Fetal Blood/cytology/*metabolism/transplantation
MH  - Humans
MH  - *Nerve Regeneration
MH  - Neurodegenerative Diseases/pathology/*therapy
MH  - Neurogenesis
RF  - 53
EDAT- 2009/10/08 06:00
MHDA- 2010/09/02 06:00
CRDT- 2009/10/08 06:00
PHST- 2008/10/10 00:00 [received]
PHST- 2009/08/25 00:00 [accepted]
PHST- 2009/10/08 06:00 [entrez]
PHST- 2009/10/08 06:00 [pubmed]
PHST- 2010/09/02 06:00 [medline]
AID - ABSTRACT # 17 [pii]
AID - 10.2174/157488810790442822 [doi]
PST - ppublish
SO  - Curr Stem Cell Res Ther. 2010 Mar;5(1):17-22. doi: 10.2174/157488810790442822.


PMID- 19804922
OWN - NLM
STAT- MEDLINE
DCOM- 20100610
LR  - 20151119
IS  - 1532-2793 (Electronic)
IS  - 0260-6917 (Linking)
VI  - 30
IP  - 4
DP  - 2010 May
TI  - Professional collaboration in students of Medicine Faculty and School of Nursing.
PG  - 350-4
LID - 10.1016/j.nedt.2009.09.007 [doi]
AB  - This descriptive study has been planned to analyze the professional collaboration
      among the students of Ege University, Faculty of Medicine and School of Nursing. 
      The study group consisted of 137 5th and 6th grade students from the Faculty of
      Medicine and 142 3rd and 4th grade students from the School of Nursing. The
      participation rate is 94%. For data collection, a questionnaire form (30
      questions) which was specially developed for the purpose of the study and the
      Jefferson Scale of Attitudes toward Physician-Nurse Collaboration (15 questions) 
      were used. Permission was granted for the research by Ege University School of
      Nursing Ethical Committee and the Office of the Dean of the Faculty of Medicine. 
      The professional collaboration mean score of the students from the Faculty of
      Medicine who participated in the study was 30.40+/-5.82 and the professional
      collaboration mean score of the students from the School of Nursing was
      26.11+/-5.27. The difference between the mean scores of professional
      collaboration was found to be significant in terms of their profession (p<0.01). 
      Physicians expressed more positive attitudes toward collaboration than nurses
      while female physicians expressed more positive attitudes toward collaboration
      than male physicians.
CI  - Published by Elsevier Ltd.
FAU - Ardahan, Melek
AU  - Ardahan M
AD  - Public Health Department, School of Nursing, Ege University, Bornova-Izmir 35100,
      Turkey. melekardahan@hotmail.com
FAU - Akcasu, Basak
AU  - Akcasu B
FAU - Engin, Esra
AU  - Engin E
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20091004
PL  - Scotland
TA  - Nurse Educ Today
JT  - Nurse education today
JID - 8511379
MH  - Adult
MH  - Analysis of Variance
MH  - *Attitude of Health Personnel/ethnology
MH  - Career Choice
MH  - *Cooperative Behavior
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Male
MH  - Nurse's Role/psychology
MH  - Nursing Methodology Research
MH  - Physician's Role/psychology
MH  - *Physician-Nurse Relations
MH  - *Professional Competence/standards
MH  - Sex Factors
MH  - Socioeconomic Factors
MH  - Students, Medical/*psychology
MH  - Students, Nursing/*psychology
MH  - Surveys and Questionnaires
MH  - Turkey
EDAT- 2009/10/07 06:00
MHDA- 2010/06/11 06:00
CRDT- 2009/10/07 06:00
PHST- 2008/09/10 00:00 [received]
PHST- 2009/07/25 00:00 [revised]
PHST- 2009/09/03 00:00 [accepted]
PHST- 2009/10/07 06:00 [entrez]
PHST- 2009/10/07 06:00 [pubmed]
PHST- 2010/06/11 06:00 [medline]
AID - S0260-6917(09)00173-7 [pii]
AID - 10.1016/j.nedt.2009.09.007 [doi]
PST - ppublish
SO  - Nurse Educ Today. 2010 May;30(4):350-4. doi: 10.1016/j.nedt.2009.09.007. Epub
      2009 Oct 4.


PMID- 19804465
OWN - NLM
STAT- MEDLINE
DCOM- 20100604
LR  - 20100118
IS  - 1360-0443 (Electronic)
IS  - 0965-2140 (Linking)
VI  - 105
IP  - 2
DP  - 2010 Feb
TI  - The alcohol industry and public interest science.
PG  - 191-8
LID - 10.1111/j.1360-0443.2009.02688.x [doi]
AB  - AIMS: This report argues that the growing involvement of the alcohol industry in 
      scientific research needs to be acknowledged and addressed. It suggests a set of 
      principles to guide ethical decision-making in the future. METHODS: We review
      relevant issues with regard to relationships between the alcohol industry and the
      international academic community, especially alcohol research scientists. The
      guiding principles proposed are modelled after expert committee statements, and
      describe the responsibilities of governmental agencies, the alcohol industry,
      journal editors and the academic community. These are followed by recommendations
      designed to inform individuals and institutions about current 'best practices'
      that are consistent with the principles. FINDINGS AND CONCLUSIONS: Growing
      evidence from the tobacco, pharmaceutical and medical fields suggests that
      financial interests of researchers may compromise their professional judgement
      and lead to research results that are biased in favour of commercial interests.
      It is recommended that the integrity of alcohol science is best served if all
      financial relationships with the alcoholic beverage industry are avoided. In
      cases where research funding, consulting, writing assignments and other
      activities are initiated, institutions, individuals and the alcoholic beverage
      industry itself are urged to follow appropriate guidelines that will increase the
      transparency and ethicality of such relationships.
FAU - Stenius, Kerstin
AU  - Stenius K
AD  - THL, National Institute for Health and Welfare, P.O. Box 30, FI00271 Helsinki,
      Finland. kerstin.stenius@thl.fi
FAU - Babor, Thomas F
AU  - Babor TF
LA  - eng
PT  - Journal Article
DEP - 20091005
PL  - England
TA  - Addiction
JT  - Addiction (Abingdon, England)
JID - 9304118
SB  - IM
CIN - Addiction. 2010 Feb;105(2):199-200; author reply 205-6. PMID: 20078473
CIN - Addiction. 2010 Feb;105(2):200-1; author reply 205-6. PMID: 20078474
CIN - Addiction. 2010 Feb;105(2):201-2; author reply 205-6. PMID: 20078475
CIN - Addiction. 2010 Feb;105(2):202-3; author reply 205-6. PMID: 20078476
CIN - Addiction. 2010 Feb;105(2):203-5; author reply 205-6. PMID: 20078477
MH  - *Alcoholic Beverages/economics
MH  - Biomedical Research/economics/*ethics/standards
MH  - *Conflict of Interest
MH  - Evidence-Based Medicine
MH  - Food Industry/*ethics/legislation & jurisprudence/standards
MH  - Government Regulation
MH  - *Guidelines as Topic
MH  - Humans
MH  - Research Support as Topic
EDAT- 2009/10/07 06:00
MHDA- 2010/06/05 06:00
CRDT- 2009/10/07 06:00
PHST- 2009/10/07 06:00 [entrez]
PHST- 2009/10/07 06:00 [pubmed]
PHST- 2010/06/05 06:00 [medline]
AID - ADD2688 [pii]
AID - 10.1111/j.1360-0443.2009.02688.x [doi]
PST - ppublish
SO  - Addiction. 2010 Feb;105(2):191-8. doi: 10.1111/j.1360-0443.2009.02688.x. Epub
      2009 Oct 5.


PMID- 19800817
OWN - NLM
STAT- MEDLINE
DCOM- 20100511
LR  - 20100203
IS  - 1532-8422 (Electronic)
IS  - 1053-0770 (Linking)
VI  - 24
IP  - 1
DP  - 2010 Feb
TI  - A prospective, randomized study of the effects of continuous ultrafiltration in
      hepatic patients after cardiac valve surgery.
PG  - 63-8
LID - 10.1053/j.jvca.2009.04.008 [doi]
AB  - OBJECTIVES: The use of continuous ultrafiltration may be effective in preventing 
      the hepatic decompensation in cirrhotic patients after valvular heart surgery
      with cardiopulmonary bypass (CPB). The authors aimed to evaluate the effects of
      continuous ultrafiltration on the need for blood transfusion, liver function
      tests, duration of postoperative ventilatory support, and the length of the
      intensive care unit (ICU) stay in cirrhotic patients undergoing valvular heart
      surgery. DESIGN: A prospective, randomized double-blinded placebo study. SETTING:
      A single university hospital. PARTICIPANTS: Sixty cirrhotic patients scheduled
      for valvular surgery. INTERVENTIONS: After local ethics committee approval and
      informed consent, participants were divided into 2 groups. In the conventional
      ultrafiltration (CUF) group (n = 30), CPB was used with conventional
      ultrafiltration. In the continuous ultrafiltration group (n = 30), in addition to
      the same CUF procedure, modified ultrafiltration was used after CPB. MEASUREMENTS
      AND MAIN RESULTS: Perioperative liver function tests, hematocrit, platelet count,
      the postoperative ventilation time, ICU and hospital length of stay,
      complications, and mortality were recorded. After CPB, patients receiving
      continuous ultrafiltration had a shorter time to extubation, postoperative
      ventilation time and ICU and hospital length of stay (p < 0.01), lower bleeding
      (p < 0.01), greater rise in hematocrit (11.3% +/- 2.39% v 4.7% +/- 1.22%, p =
      0.001) and platelet count (7.0 +/- 3.0 v 0.8 +/- 0.21 10(4)/micromL, p = 0.001), 
      higher albumin levels (p < 0.001), and lower plasma levels of bilirubin,
      aminotransferase, alkaline phosphatase, and gamma-glutamyl transpeptidase (p <
      0.02). There was no significant difference between the 2 groups in the dosage of 
      nitroglycerin or epinephrine, morbidity, or mortality. CONCLUSIONS: The authors
      concluded that continuous ultrafiltration reduced postoperative bleeding and
      blood transfusions, improved liver function, and shortened the hospital stay in
      cirrhotic patients after valvular heart surgery.
CI  - Copyright 2010. Published by Elsevier Inc.
FAU - El-Tahan, Mohamed R
AU  - El-Tahan MR
AD  - Department of Anesthesia and Surgical ICU, King Faisal University, Dammam,
      Kingdom of Saudi Arabia. mohamedrefaateltahan@yahoo.com
FAU - Hamad, Reda A
AU  - Hamad RA
FAU - Ghoneimy, Yasser F
AU  - Ghoneimy YF
FAU - El Shehawi, Mohamed I
AU  - El Shehawi MI
FAU - Shafi, Mohamed A
AU  - Shafi MA
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20091002
PL  - United States
TA  - J Cardiothorac Vasc Anesth
JT  - Journal of cardiothoracic and vascular anesthesia
JID - 9110208
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Cardiopulmonary Bypass
MH  - Double-Blind Method
MH  - Female
MH  - Heart Valve Diseases/complications/*surgery
MH  - Hematocrit
MH  - Humans
MH  - Length of Stay
MH  - Liver Cirrhosis/*complications/mortality/physiopathology
MH  - Liver Function Tests
MH  - Male
MH  - Middle Aged
MH  - Platelet Count
MH  - Postoperative Complications/*prevention & control
MH  - Prospective Studies
MH  - Prothrombin Time
MH  - Treatment Outcome
MH  - Ultrafiltration/*methods
MH  - Young Adult
EDAT- 2009/10/06 06:00
MHDA- 2010/05/12 06:00
CRDT- 2009/10/06 06:00
PHST- 2008/12/06 00:00 [received]
PHST- 2009/10/06 06:00 [entrez]
PHST- 2009/10/06 06:00 [pubmed]
PHST- 2010/05/12 06:00 [medline]
AID - S1053-0770(09)00112-8 [pii]
AID - 10.1053/j.jvca.2009.04.008 [doi]
PST - ppublish
SO  - J Cardiothorac Vasc Anesth. 2010 Feb;24(1):63-8. doi: 10.1053/j.jvca.2009.04.008.
      Epub 2009 Oct 2.


PMID- 19799924
OWN - NLM
STAT- MEDLINE
DCOM- 20100408
LR  - 20220318
IS  - 1879-3150 (Electronic)
IS  - 0041-0101 (Linking)
VI  - 55
IP  - 2-3
DP  - 2010 Feb-Mar
TI  - A review of epidemiological, clinical and in vitro physiological studies of
      envenomation by the scorpion Hemiscorpius lepturus (Hemiscorpiidae) in Iran.
PG  - 173-9
LID - 10.1016/j.toxicon.2009.09.012 [doi]
AB  - Many of the published accounts of envenomation by Hemiscorpius lepturus (H.
      lepturus) are in a form that makes it difficult for non Farsi readers to access. 
      The purpose of this review is to summarise the Iranian literature on the
      toxinological effects of the venom of H. lepturus using both in vivo and in vitro
      data and where appropriate, details of methods and ethics statements will be
      reported.
CI  - Copyright 2009 Elsevier Ltd. All rights reserved.
FAU - Jalali, Amir
AU  - Jalali A
AD  - Dept. of Pharmacology and Toxicology, School of Pharmacy, Jundishapur University 
      of Medical Sciences, Ahvaz, Iran. amjalali60@hotmail.com
FAU - Pipelzadeh, Mohammad H
AU  - Pipelzadeh MH
FAU - Sayedian, Ramin
AU  - Sayedian R
FAU - Rowan, E G
AU  - Rowan EG
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20090930
PL  - England
TA  - Toxicon
JT  - Toxicon : official journal of the International Society on Toxinology
JID - 1307333
RN  - 0 (Scorpion Venoms)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Animals
MH  - Child
MH  - Child, Preschool
MH  - Humans
MH  - Infant
MH  - Iran/epidemiology
MH  - Lethal Dose 50
MH  - Middle Aged
MH  - Scorpion Stings/*epidemiology/pathology/*physiopathology/therapy
MH  - Scorpion Venoms/*toxicity
MH  - Scorpions
MH  - Seasons
MH  - Treatment Outcome
MH  - Young Adult
RF  - 61
EDAT- 2009/10/06 06:00
MHDA- 2010/04/09 06:00
CRDT- 2009/10/06 06:00
PHST- 2008/10/08 00:00 [received]
PHST- 2009/08/25 00:00 [revised]
PHST- 2009/09/10 00:00 [accepted]
PHST- 2009/10/06 06:00 [entrez]
PHST- 2009/10/06 06:00 [pubmed]
PHST- 2010/04/09 06:00 [medline]
AID - S0041-0101(09)00463-2 [pii]
AID - 10.1016/j.toxicon.2009.09.012 [doi]
PST - ppublish
SO  - Toxicon. 2010 Feb-Mar;55(2-3):173-9. doi: 10.1016/j.toxicon.2009.09.012. Epub
      2009 Sep 30.


PMID- 19793135
OWN - NLM
STAT- MEDLINE
DCOM- 20100819
LR  - 20211020
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 10
IP  - 2
DP  - 2010 Aug
TI  - Access to treatment in HIV prevention trials: perspectives from a South African
      community.
PG  - 78-87
LID - 10.1111/j.1471-8847.2009.00265.x [doi]
AB  - Access to treatment, in HIV vaccine trials (HVTs), remains ethically
      controversial. In most prevention trials, including in South Africa, participants
      who seroconvert are referred to publicly funded programmes for treatment. This
      strategy is problematic when there is inadequate and uneven access to public
      sector antiretroviral therapy (ART) and support resources. The responsibilities, 
      if any, of researchers, sponsors and public health authorities involved in HVTs
      has been hotly debated among academics, scholars, representatives of
      international organizations and sponsors. However, there is little published on
      community perceptions. Recent guidance asserts that communities should make
      inputs into treatment and care decisions. This qualitative study explored a South
      African community's perceptions of who should provide what to HVT participants as
      well as how and why this should be done. Twenty-nine adults working at or
      attending five primary health care clinics in two rural areas in KwaZulu-Natal
      participated in in-depth interviews. Respondents expressed that researchers
      should 'help participants to access' treatment and care 'because they are in a
      position to do so' and 'are in a relationship with' trial participants.
      Respondents suggested that researchers could help by 'facilitating referral'
      until such time that participants can access care and treatment on their own. We 
      highlight a series of implications for researchers in HVTs, including their need 
      to be aware of prospective participants' considerable trust in and respect for
      researchers, the responsibility that this places on them, and the need for clear 
      communication with communities so as not to erode community trust.
FAU - Barsdorf, Nicola
AU  - Barsdorf N
AD  - Johns Hopkins-Fogarty African Bioethics Training Program, School of Psychology,
      Scottsville, Pietermaritzburg, KwaZulu-Natal 3209, South Africa.
      nicolabarsdorf@gmail.com
FAU - Maman, Suzanne
AU  - Maman S
FAU - Kass, Nancy
AU  - Kass N
FAU - Slack, Catherine
AU  - Slack C
LA  - eng
GR  - R25 TW001604/TW/FIC NIH HHS/United States
GR  - R25 TW001604-03/TW/FIC NIH HHS/United States
PT  - Journal Article
DEP - 20090927
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
RN  - 0 (AIDS Vaccines)
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - AIDS Vaccines/*administration & dosage
MH  - Adult
MH  - Anti-HIV Agents/*administration & dosage
MH  - Clinical Trials as Topic/*ethics
MH  - Community-Based Participatory Research/ethics
MH  - Female
MH  - HIV Infections/*prevention & control
MH  - HIV Seropositivity/*drug therapy
MH  - Health Services Accessibility/*ethics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Qualitative Research
MH  - Referral and Consultation
MH  - Research Personnel/ethics
MH  - Researcher-Subject Relations/*ethics
MH  - Rural Population
MH  - Sampling Studies
MH  - South Africa/epidemiology
MH  - Surveys and Questionnaires
MH  - *Trust
PMC - PMC2891264
MID - NIHMS147066
EDAT- 2009/10/02 06:00
MHDA- 2010/08/20 06:00
CRDT- 2009/10/02 06:00
PHST- 2009/10/02 06:00 [entrez]
PHST- 2009/10/02 06:00 [pubmed]
PHST- 2010/08/20 06:00 [medline]
AID - DEWB265 [pii]
AID - 10.1111/j.1471-8847.2009.00265.x [doi]
PST - ppublish
SO  - Dev World Bioeth. 2010 Aug;10(2):78-87. doi: 10.1111/j.1471-8847.2009.00265.x.
      Epub 2009 Sep 27.


PMID- 19787458
OWN - NLM
STAT- MEDLINE
DCOM- 20111130
LR  - 20211020
IS  - 1573-3394 (Electronic)
IS  - 1065-3058 (Linking)
VI  - 18
IP  - 3
DP  - 2010 Sep
TI  - Serve the people: understanding ideology and professional ethics of medicine in
      China.
PG  - 294-309
LID - 10.1007/s10728-009-0127-y [doi]
AB  - The article explores the communist ideology that has guided the formation of
      professional ethics of medicine in China. It first explores the constitutions of 
      the People's Republic of China and the Chinese Communist Party and codes of
      practice for medicine enforced since 1949, showing that the core of the ideology 
      in relation to health provision and doctor-patient relationship has always been
      'serving the people wholeheartedly'. The ideological undertaking, however, has
      never been successfully exercised. In the pre-reform era, the bureaucratisation
      of health professionals led to the emergence of 'bureaucratic medicine' featuring
      negligence of patients' interests. In the reform era, the prevailing
      commercialisation of health care is in fundamental conflict with the ideological 
      commitment to serving the people. As a result, the socialist professional ethics 
      of medicine has not been satisfactorily practiced in reality.
FAU - Yang, Jingqing
AU  - Yang J
AD  - Faculty of Arts and Social Sciences, University of Technology, Sydney, Broadway, 
      P.O. Box 123, Sydney, NSW, 2007, Australia. Jingqing.yang@uts.edu.au
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - Netherlands
TA  - Health Care Anal
JT  - Health care analysis : HCA : journal of health philosophy and policy
JID - 9432537
MH  - China
MH  - Communism
MH  - Delivery of Health Care/*ethics
MH  - Ethics, Medical/*history
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Physician-Patient Relations/*ethics
MH  - Socialism
EDAT- 2009/09/30 06:00
MHDA- 2011/12/13 00:00
CRDT- 2009/09/30 06:00
PHST- 2009/09/30 06:00 [entrez]
PHST- 2009/09/30 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/s10728-009-0127-y [doi]
PST - ppublish
SO  - Health Care Anal. 2010 Sep;18(3):294-309. doi: 10.1007/s10728-009-0127-y.


PMID- 19787457
OWN - NLM
STAT- MEDLINE
DCOM- 20111130
LR  - 20211020
IS  - 1573-3394 (Electronic)
IS  - 1065-3058 (Linking)
VI  - 18
IP  - 3
DP  - 2010 Sep
TI  - The ethics of nonmedical sex selection.
PG  - 252-66
LID - 10.1007/s10728-009-0135-y [doi]
AB  - The aim of this paper is to demonstrate that there are significant ethical
      problems with nonmedical sex selection, and that prohibitive legislation is
      justified. The central argument put forward is that nonmedical sex selection is a
      sexist practice which promotes socially restrictive conceptions of sex, gender
      and family. Several steps are taken to justify this position: background
      information on technology and legislation is provided, the neoliberal position
      that is supportive of nonmedical sex selection is described, and preliminary
      reasons for rejecting this approach are given. A detailed description of how a
      harm/benefit based analysis contributes to the argument against nonmedical sex
      selection, and how it successfully counters most criticism, is provided. The
      paper concludes by suggesting that virtue ethics further strengthens the moral
      argument against nonmedical sex selection.
FAU - Strange, H
AU  - Strange H
AD  - cesagen (ESRC Centre for the Economic and Social Aspects of Genomics), Cardiff
      University, 6 Museum Place, Cardiff, CF10 3BG, UK. StrangeHR1@cf.ac.uk
FAU - Chadwick, R
AU  - Chadwick R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Health Care Anal
JT  - Health care analysis : HCA : journal of health philosophy and policy
JID - 9432537
MH  - *Bioethical Issues
MH  - Female
MH  - Humans
MH  - Male
MH  - Reproductive Techniques, Assisted/*ethics
MH  - Sex Preselection/*ethics
EDAT- 2009/09/30 06:00
MHDA- 2011/12/13 00:00
CRDT- 2009/09/30 06:00
PHST- 2009/09/30 06:00 [entrez]
PHST- 2009/09/30 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/s10728-009-0135-y [doi]
PST - ppublish
SO  - Health Care Anal. 2010 Sep;18(3):252-66. doi: 10.1007/s10728-009-0135-y.


PMID- 19785933
OWN - NLM
STAT- MEDLINE
DCOM- 20100809
LR  - 20220408
IS  - 2044-8341 (Electronic)
IS  - 1476-0835 (Linking)
VI  - 83
IP  - Pt 2
DP  - 2010 Jun
TI  - The experience and meaning of compassion and self-compassion for individuals with
      depression or anxiety.
PG  - 129-43
LID - 10.1348/147608309X471000 [doi]
AB  - OBJECTIVES: The objective of this study was to explore the meaning and
      experiences of compassion and self-compassion for individuals with depression and
      anxiety. DESIGN: An interpretative phenomenological analysis (IPA) epistemology
      and methodology were adopted as the study was focused on understanding the
      meaning and experiences of participants towards self-compassion from existing
      theory. METHODS: Ten participants were selected based on a Diagnostic and
      Statistical Manual of Mental Disorders, 4th Ed.-text revision diagnosis of
      depression or an anxiety disorder. Individuals were excluded from this study if
      they had additional diagnoses which impacted significantly on their disorder or
      on ethical grounds if participation was seen as psychologically distressing.
      Participants completed a semi-structured interview with questions were based on
      existing self-compassion research. Interviews lasted an hour and were analysed
      using IPA methodology. RESULTS: Participants' reflections suggested that they saw
      compassion having two central qualities: kindness and action. Participants
      reported that they thought having compassion for themselves felt meaningful in
      relation to their experiences and useful in helping with their depression or
      anxiety. However, participants reflected that they felt being self-compassionate 
      would be difficult either because the concept itself felt challenging to enact or
      their experience of psychological disorder had negatively impacted on their
      ability to be self-compassionate. CONCLUSIONS: Participants' positive perceptions
      of self-compassion offer encouragement to clinicians as it appears people can
      connect with the concept meaningfully as well as seeing it as being useful.
      Clinicians focusing on self-compassion may gain greater efficacy when they
      incorporate both aspects within interventions. Findings about the difficulties
      associated with self-compassion provide valuable information as to why people
      find it difficult to adopt which can be used in the development of future
      clinical interventions.
FAU - Pauley, Gerard
AU  - Pauley G
AD  - Hitchin CMHT, Hertfordshire Partnership Foundation Trust, Hitchin, UK.
      gerardpauley@hotmail.com
FAU - McPherson, Susan
AU  - McPherson S
LA  - eng
PT  - Journal Article
DEP - 20090925
PL  - England
TA  - Psychol Psychother
JT  - Psychology and psychotherapy
JID - 101135751
SB  - IM
MH  - Adult
MH  - Anxiety Disorders/diagnosis/epidemiology/*psychology
MH  - *Attitude
MH  - Depression/diagnosis/epidemiology/*psychology
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - *Empathy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Self Concept
MH  - Severity of Illness Index
MH  - Young Adult
EDAT- 2009/09/30 06:00
MHDA- 2010/08/10 06:00
CRDT- 2009/09/30 06:00
PHST- 2009/09/30 06:00 [entrez]
PHST- 2009/09/30 06:00 [pubmed]
PHST- 2010/08/10 06:00 [medline]
AID - pptrp474 [pii]
AID - 10.1348/147608309X471000 [doi]
PST - ppublish
SO  - Psychol Psychother. 2010 Jun;83(Pt 2):129-43. doi: 10.1348/147608309X471000. Epub
      2009 Sep 25.


PMID- 19782117
OWN - NLM
STAT- MEDLINE
DCOM- 20100429
LR  - 20100209
IS  - 1096-0295 (Electronic)
IS  - 0273-2300 (Linking)
VI  - 56
IP  - 1
DP  - 2010 Feb
TI  - Current regulatory perspectives on genotoxicity testing for botanical drug
      product development in the U.S.A.
PG  - 1-3
LID - 10.1016/j.yrtph.2009.09.012 [doi]
AB  - Genotoxicity testing is an important part of preclinical safety assessment of new
      drugs and is required prior to Phase I/II clinical trials. It is designed to
      detect genetic damage such as gene mutations and chromosomal aberration, which
      may be reflected in tumorigenic or heritable mutation potential of the drug.
      Botanical new drugs in the U.S. are entitled to a waiver for preclinical
      pharmacology/toxicology studies, including genotoxicity testing, in support of an
      initial clinical trial under IND, contingent on previous human experience.
      Recently, ethical concerns have been raised over conducting Phase I/II clinical
      trials of new drugs with positive genotoxicity findings in healthy volunteers.
      Although the relevance of this issue to patients, as opposed to healthy
      volunteers, depends on the drug's indication, duration of treatment, and specific
      findings related to the assays, the regulatory view is to avoid exposing patients
      to genotoxic compounds unnecessarily in clinical trials. This philosophy may
      impact on herbal supplement marketing and botanical drug development, in that
      genotoxicity data are often lacking while consumers are exposed to the herbal
      supplement, or healthy volunteers are tested in an initial Phase I/II clinical
      trial on the botanical drug. This paper presents results of a survey conducted on
      genotoxicity data in botanical INDs submitted to the Agency and discusses the
      significance of this information. The information presented indicates that the
      sponsors of botanical INDs have increasingly recognized the importance of
      genotoxicity information and may have prioritized its acquisition in their
      strategic drug development programs.
CI  - Published by Elsevier Inc.
FAU - Wu, Kuei-Meng
AU  - Wu KM
AD  - Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New 
      Hampshire Avenue, Silver Spring, MD 20993, USA. kueimeng.wu@fda.hhs.gov
FAU - Dou, Jinhui
AU  - Dou J
FAU - Ghantous, Hanan
AU  - Ghantous H
FAU - Chen, Shaw
AU  - Chen S
FAU - Bigger, Anita
AU  - Bigger A
FAU - Birnkrant, Debra
AU  - Birnkrant D
LA  - eng
PT  - Journal Article
DEP - 20090924
PL  - Netherlands
TA  - Regul Toxicol Pharmacol
JT  - Regulatory toxicology and pharmacology : RTP
JID - 8214983
RN  - 0 (Drugs, Investigational)
RN  - 0 (Plant Preparations)
SB  - IM
MH  - Clinical Trials as Topic/statistics & numerical data
MH  - Drug Approval/*statistics & numerical data
MH  - Drugs, Investigational/*toxicity
MH  - Humans
MH  - Investigational New Drug Application/*statistics & numerical data
MH  - Mutagenicity Tests/statistics & numerical data
MH  - Plant Preparations/*toxicity
MH  - *Therapeutic Human Experimentation
MH  - United States
EDAT- 2009/09/29 06:00
MHDA- 2010/04/30 06:00
CRDT- 2009/09/29 06:00
PHST- 2009/07/06 00:00 [received]
PHST- 2009/09/02 00:00 [revised]
PHST- 2009/09/03 00:00 [accepted]
PHST- 2009/09/29 06:00 [entrez]
PHST- 2009/09/29 06:00 [pubmed]
PHST- 2010/04/30 06:00 [medline]
AID - S0273-2300(09)00197-4 [pii]
AID - 10.1016/j.yrtph.2009.09.012 [doi]
PST - ppublish
SO  - Regul Toxicol Pharmacol. 2010 Feb;56(1):1-3. doi: 10.1016/j.yrtph.2009.09.012.
      Epub 2009 Sep 24.


PMID- 19781830
OWN - NLM
STAT- MEDLINE
DCOM- 20100202
LR  - 20181201
IS  - 1523-6838 (Electronic)
IS  - 0272-6386 (Linking)
VI  - 55
IP  - 1
DP  - 2010 Jan
TI  - Care of the undocumented immigrant in the United States with ESRD.
PG  - 181-91
LID - 10.1053/j.ajkd.2009.06.039 [doi]
AB  - The growth of the undocumented immigrant population in the United States has been
      explosive. The absence of a uniform policy regarding health care for this
      population has created a unique problem for nephrologists. How should provision
      of care for undocumented immigrants with end-stage renal disease be delivered and
      compensated? This problem is exacerbated by the multiple complex laws that govern
      delivery of and payment for care, as well as that state regulations vary widely
      and are not easily understood. Furthermore, the ethical and moral commitments of 
      providers to ensure adequate and appropriate care for any patient whose life is
      at stake, irrespective of his or her immigration status, place nephrologists in a
      difficult position. This review focuses on the scope of this problem, relevant
      case law and legislation, current care and payment models, the response of
      nephrology groups, and ethical dilemmas inherent in caring for this vulnerable
      population. Recommendations for further study, including convening of a consensus
      conference, are discussed.
CI  - Copyright 2009 National Kidney Foundation, Inc. Published by Elsevier Inc. All
      rights reserved.
FAU - Campbell, G Adam
AU  - Campbell GA
AD  - Division of Nephrology, University of Virginia Health System, Charlottesville, VA
      22908, USA.
FAU - Sanoff, Scott
AU  - Sanoff S
FAU - Rosner, Mitchell H
AU  - Rosner MH
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20090925
PL  - United States
TA  - Am J Kidney Dis
JT  - American journal of kidney diseases : the official journal of the National Kidney
      Foundation
JID - 8110075
SB  - IM
MH  - Delivery of Health Care/*organization & administration
MH  - Humans
MH  - Kidney Failure, Chronic/ethnology/*therapy
MH  - Renal Replacement Therapy/*statistics & numerical data
MH  - Transients and Migrants/*statistics & numerical data
MH  - United States/epidemiology
RF  - 39
EDAT- 2009/09/29 06:00
MHDA- 2010/02/03 06:00
CRDT- 2009/09/29 06:00
PHST- 2009/03/25 00:00 [received]
PHST- 2009/06/08 00:00 [accepted]
PHST- 2009/09/29 06:00 [entrez]
PHST- 2009/09/29 06:00 [pubmed]
PHST- 2010/02/03 06:00 [medline]
AID - S0272-6386(09)00989-5 [pii]
AID - 10.1053/j.ajkd.2009.06.039 [doi]
PST - ppublish
SO  - Am J Kidney Dis. 2010 Jan;55(1):181-91. doi: 10.1053/j.ajkd.2009.06.039. Epub
      2009 Sep 25.


PMID- 19781806
OWN - NLM
STAT- MEDLINE
DCOM- 20101103
LR  - 20220409
IS  - 1872-8332 (Electronic)
IS  - 0169-5002 (Linking)
VI  - 69
IP  - 1
DP  - 2010 Jul
TI  - Quantitative helical dynamic contrast enhanced computed tomography assessment of 
      the spatial variation in whole tumour blood volume with radiotherapy in lung
      cancer.
PG  - 71-6
LID - 10.1016/j.lungcan.2009.09.002 [doi]
AB  - We aim to assess the spatial distribution of blood volume (BV) in whole lung
      tumours in patients undergoing radiotherapy using helical dynamic contrast
      enhanced computed tomography (DCE-CT), and to determine whether conventional
      single level, or whole tumour measurements is more representative of the vascular
      effects of radiotherapy. Following ethical approval and informed consent, 15
      patients with histologically proven non-small cell lung cancer underwent paired
      helical DCE-CT studies at baseline to assess repeatability, and after two
      fractions of radiotherapy (9 Gy total dose). Tumour BV was calculated for
      individual contiguous 10mm axial slices, and for the entire tumour volume on a
      pixel-per-pixel basis. Baseline tumour BV was heterogeneous varying by
      15.33%+/-17.11 between adjacent 10mm axial slices. Within subject coefficient of 
      variation was 36.72% with conventional single tumour level evaluation, and 13.62%
      with whole tumour measurements. Following radiotherapy, one patient had an
      increase in BV greater than baseline variation (derived from the 95% limits of
      change) using single level evaluation; in contrast, seven patients had an
      increase in BV when the whole tumour was assessed. As a group, following
      radiotherapy, mean BV increased by 17.27% (paired t-test, p=0.20) with single
      level evaluation and 19.26% (p=0.049) with whole tumour assessment. Tumour BV
      measured using DCE-CT is spatially heterogeneous. Given the slice-by-slice
      variation in blood volume, our results demonstrate that whole tumour DCE-CT
      measurements are more repeatable, and may be a better predictor of vascular
      changes following therapy, compared to conventional single tumour level
      evaluations.
CI  - Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
FAU - Ng, Quan-Sing
AU  - Ng QS
AD  - National Cancer Centre, Singapore.
FAU - Goh, Vicky
AU  - Goh V
FAU - Milner, Jessica
AU  - Milner J
FAU - Sundin, Josefin
AU  - Sundin J
FAU - Wellsted, David
AU  - Wellsted D
FAU - Saunders, Michele I
AU  - Saunders MI
FAU - Hoskin, Peter J
AU  - Hoskin PJ
LA  - eng
GR  - Cancer Research UK/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090924
PL  - Ireland
TA  - Lung Cancer
JT  - Lung cancer (Amsterdam, Netherlands)
JID - 8800805
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Blood Volume Determination/*methods/statistics & numerical data
MH  - Carcinoma, Non-Small-Cell Lung/blood supply/*diagnostic imaging/radiotherapy
MH  - Female
MH  - Humans
MH  - Lung/*diagnostic imaging
MH  - Lung Neoplasms/blood supply/*diagnostic imaging/radiotherapy
MH  - Male
MH  - Middle Aged
MH  - Neovascularization, Pathologic/radiotherapy
MH  - Predictive Value of Tests
MH  - Reference Values
MH  - Reproducibility of Results
MH  - *Tomography, Spiral Computed
EDAT- 2009/09/29 06:00
MHDA- 2010/11/04 06:00
CRDT- 2009/09/29 06:00
PHST- 2009/02/23 00:00 [received]
PHST- 2009/08/27 00:00 [revised]
PHST- 2009/09/01 00:00 [accepted]
PHST- 2009/09/29 06:00 [entrez]
PHST- 2009/09/29 06:00 [pubmed]
PHST- 2010/11/04 06:00 [medline]
AID - S0169-5002(09)00486-3 [pii]
AID - 10.1016/j.lungcan.2009.09.002 [doi]
PST - ppublish
SO  - Lung Cancer. 2010 Jul;69(1):71-6. doi: 10.1016/j.lungcan.2009.09.002. Epub 2009
      Sep 24.


PMID- 19780036
OWN - NLM
STAT- MEDLINE
DCOM- 20100511
LR  - 20211020
IS  - 1552-5015 (Electronic)
IS  - 1552-5007 (Linking)
VI  - 314
IP  - 2
DP  - 2010 Mar 15
TI  - Generation of neural crest progenitors from human embryonic stem cells.
PG  - 95-103
LID - 10.1002/jez.b.21321 [doi]
AB  - The neural crest (NC) is a transient population of multipotent progenitors
      arising at the lateral edge of the neural plate in vertebrate embryos, which then
      migrate throughout the body to generate diverse array of tissues such as the
      peripheral nervous system, skin melanocytes, and craniofacial cartilage, bone and
      teeth. The transient nature of neural crest stem cells make extremely challenging
      to study the biology of these important cells. In humans induction and
      differentiation of embryonic NC occurs very early, within a few weeks of
      fertilization giving rise to technical and ethical issues surrounding isolation
      of early embryonic tissues and therefore severely limiting the study of human NC 
      cells. For that reason our current knowledge of the biology of NC mostly derives 
      from the studies of lower organisms. Recent progress in human embryonic stem cell
      research provides a unique opportunity for generation of a useful source of cells
      for basic developmental studies. The development of cost-effective, time and
      labor efficient improved differentiation protocols for the production of human NC
      cells is a critical step toward a better understanding of NC biology.
FAU - Chimge, Nyam-Osor
AU  - Chimge NO
AD  - Department of Reconstructive Sciences, University of Connecticut Health Center,
      Farmington, Connecticut, USA.
FAU - Bayarsaihan, Dashzeveg
AU  - Bayarsaihan D
LA  - eng
GR  - K02 DE018412/DE/NIDCR NIH HHS/United States
GR  - R01 DE017205/DE/NIDCR NIH HHS/United States
GR  - K02 DE18412/DE/NIDCR NIH HHS/United States
GR  - R01DE017205/DE/NIDCR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United States
TA  - J Exp Zool B Mol Dev Evol
JT  - Journal of experimental zoology. Part B, Molecular and developmental evolution
JID - 101168228
RN  - 0 (Biomarkers)
SB  - IM
MH  - Animals
MH  - Biomarkers
MH  - Cell Culture Techniques
MH  - Cell Differentiation/*physiology
MH  - Cell Separation
MH  - Coculture Techniques
MH  - Embryonic Stem Cells/*cytology/metabolism
MH  - Humans
MH  - Mice
MH  - Multipotent Stem Cells/*cytology/physiology
MH  - Neural Crest/*cytology/embryology/metabolism
RF  - 71
EDAT- 2009/09/26 06:00
MHDA- 2010/05/12 06:00
CRDT- 2009/09/26 06:00
PHST- 2009/09/26 06:00 [entrez]
PHST- 2009/09/26 06:00 [pubmed]
PHST- 2010/05/12 06:00 [medline]
AID - 10.1002/jez.b.21321 [doi]
PST - ppublish
SO  - J Exp Zool B Mol Dev Evol. 2010 Mar 15;314(2):95-103. doi: 10.1002/jez.b.21321.


PMID- 19779975
OWN - NLM
STAT- MEDLINE
DCOM- 20111130
LR  - 20211020
IS  - 1573-3394 (Electronic)
IS  - 1065-3058 (Linking)
VI  - 18
IP  - 3
DP  - 2010 Sep
TI  - Ethical dilemmas and ethical competence in the daily work of research nurses.
PG  - 239-51
LID - 10.1007/s10728-009-0126-z [doi]
AB  - In spite of the growing interest in nursing ethics, few studies have focused on
      ethical dilemmas experienced by nurses working with clinical studies as 'research
      nurses'. The aim of the present study was to describe and explore ethical
      dilemmas that Swedish research nurses experience in their day-to-day work. In a
      qualitative study a purposeful sample of six research nurses from five wards of
      differing disciplines in four Swedish hospitals was interviewed. The analysis
      displayed several examples of ethical dilemmas, primarily tensions between the
      nurses' obligations to the study and to the patients involved. A guiding moral
      principle for the nurses was patient-centeredness, where the interest of research
      must not override the interest of the patient. In situations where tensions
      between research and patient interests occurred, and doctors and nurses disagreed
      upon the judgement, the nurses sometimes chose to follow the doctors' advice, and
      thus acted against their own moral judgment. Such situations seemed to create
      feelings of moral distress among the nurses. They described their profession as
      being 'invisible' and as lacking opportunities for ethical competence building.
      The conclusion is that research nurses frequently experience severe and difficult
      ethical dilemmas in their daily work. They need to be acknowledged as a
      particular profession in the health care organisation and encouraged to develop
      their specific ethical competence.
FAU - Hoglund, A T
AU  - Hoglund AT
AD  - Centre for Research Ethics and Bioethics, Department of Public Health and Caring 
      Sciences, Uppsala University, Uppsala Science Park, 751 85, Uppsala, Sweden.
      anna.hoglund@crb.uu.se
FAU - Helgesson, G
AU  - Helgesson G
FAU - Eriksson, S
AU  - Eriksson S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090925
PL  - Netherlands
TA  - Health Care Anal
JT  - Health care analysis : HCA : journal of health philosophy and policy
JID - 9432537
MH  - Adult
MH  - Clinical Competence
MH  - Decision Making/*ethics
MH  - *Ethics, Nursing
MH  - Humans
MH  - Middle Aged
MH  - Morals
MH  - Nurse-Patient Relations/ethics
MH  - Nursing Methodology Research/*ethics
MH  - Nursing Staff, Hospital/ethics/psychology
MH  - Physician-Nurse Relations
MH  - Qualitative Research
MH  - Sweden
EDAT- 2009/09/26 06:00
MHDA- 2011/12/13 00:00
CRDT- 2009/09/26 06:00
PHST- 2009/02/04 00:00 [received]
PHST- 2009/06/08 00:00 [accepted]
PHST- 2009/09/26 06:00 [entrez]
PHST- 2009/09/26 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/s10728-009-0126-z [doi]
PST - ppublish
SO  - Health Care Anal. 2010 Sep;18(3):239-51. doi: 10.1007/s10728-009-0126-z. Epub
      2009 Sep 25.


PMID- 19779473
OWN - NLM
STAT- MEDLINE
DCOM- 20100813
LR  - 20220331
IS  - 1930-739X (Electronic)
IS  - 1930-7381 (Linking)
VI  - 18
IP  - 3
DP  - 2010 Mar
TI  - Ultrasound measurements of visceral and subcutaneous abdominal thickness to
      predict abdominal adiposity among older men and women.
PG  - 625-31
LID - 10.1038/oby.2009.309 [doi]
AB  - Accurate measures of visceral and abdominal subcutaneous fat are essential for
      investigating the pathophysiology of obesity. Classical anthropometric measures
      such as waist and hip circumference cannot distinguish between these two fat
      depots. Direct imaging methods such as computed tomography and magnetic resonance
      imaging (MRI) are restricted in large-scale studies due to practical and ethical 
      issues. We aimed to establish whether ultrasound is a valid alternative method to
      MRI for the quantitative assessment of abdominal fat depots in older individuals.
      The study population comprised 74 white individuals (41 men and 33 women, aged
      67-76 years) participating in the Hertfordshire Birth Cohort Physical Activity
      trial. Anthropometry included height, weight, waist and hip circumferences.
      Abdominal fat was measured by ultrasound in two compartments: visceral fat
      defined as the depth from the peritoneum to the lumbar spine; and subcutaneous
      fat defined as the depth from the skin to the abdominal muscles and compared to
      reference measures by MRI (10-mm single-slice image). Ultrasound measures were
      positively correlated with MRI measures of visceral and subcutaneous fat
      (visceral: r = 0.82 and r = 0.80 in men and women, respectively; subcutaneous: r 
      = 0.63 and 0.68 in men and women, respectively). In multiple regression models,
      the addition of ultrasound measures significantly improved the prediction of
      visceral fat and subcutaneous fat in both men and women over and above the
      contribution of standard anthropometric variables. In conclusion, ultrasound is a
      valid method to estimate visceral fat in epidemiological studies of older men and
      women when MRI and computed tomography are not feasible.
FAU - De Lucia Rolfe, Ema
AU  - De Lucia Rolfe E
AD  - MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital,
      Cambridge, UK. ed219@mrc-epid.cam.ac.uk
FAU - Sleigh, Alison
AU  - Sleigh A
FAU - Finucane, Francis M
AU  - Finucane FM
FAU - Brage, Soren
AU  - Brage S
FAU - Stolk, Ronald P
AU  - Stolk RP
FAU - Cooper, Cyrus
AU  - Cooper C
FAU - Sharp, Stephen J
AU  - Sharp SJ
FAU - Wareham, Nicholas J
AU  - Wareham NJ
FAU - Ong, Ken K
AU  - Ong KK
LA  - eng
GR  - G0701532/MRC_/Medical Research Council/United Kingdom
GR  - MC_U106179472/MRC_/Medical Research Council/United Kingdom
GR  - MC_UP_A620_1014/MRC_/Medical Research Council/United Kingdom
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20090924
PL  - United States
TA  - Obesity (Silver Spring)
JT  - Obesity (Silver Spring, Md.)
JID - 101264860
SB  - IM
MH  - *Adiposity
MH  - Aged
MH  - *Anthropometry
MH  - Body Height
MH  - Body Weight
MH  - Female
MH  - Hip
MH  - Humans
MH  - Intra-Abdominal Fat/*diagnostic imaging/pathology
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Obesity, Abdominal/*diagnostic imaging/pathology
MH  - Reference Values
MH  - Reproducibility of Results
MH  - Subcutaneous Fat, Abdominal/*diagnostic imaging/pathology
MH  - Ultrasonography
MH  - Waist Circumference
EDAT- 2009/09/26 06:00
MHDA- 2010/08/14 06:00
CRDT- 2009/09/26 06:00
PHST- 2009/09/26 06:00 [entrez]
PHST- 2009/09/26 06:00 [pubmed]
PHST- 2010/08/14 06:00 [medline]
AID - oby2009309 [pii]
AID - 10.1038/oby.2009.309 [doi]
PST - ppublish
SO  - Obesity (Silver Spring). 2010 Mar;18(3):625-31. doi: 10.1038/oby.2009.309. Epub
      2009 Sep 24.


PMID- 19777372
OWN - NLM
STAT- MEDLINE
DCOM- 20100319
LR  - 20211020
IS  - 1572-8633 (Electronic)
IS  - 1386-7423 (Linking)
VI  - 13
IP  - 1
DP  - 2010 Feb
TI  - Molecular medicine and concepts of disease: the ethical value of a conceptual
      analysis of emerging biomedical technologies.
PG  - 11-23
LID - 10.1007/s11019-009-9223-x [doi]
AB  - Although it is now generally acknowledged that new biomedical technologies often 
      produce new definitions and sometimes even new concepts of disease, this
      observation is rarely used in research that anticipates potential ethical issues 
      in emerging technologies. This article argues that it is useful to start with an 
      analysis of implied concepts of disease when anticipating ethical issues of
      biomedical technologies. It shows, moreover, that it is possible to do so at an
      early stage, i.e. when a technology is only just emerging. The specific case
      analysed here is that of 'molecular medicine'. This group of emerging
      technologies combines a 'cascade model' of disease processes with a 'personal
      pattern' model of bodily functioning. Whereas the ethical implications of the
      first are partly familiar from earlier--albeit controversial--forms of preventive
      and predictive medicine, those of the second are quite novel and potentially
      far-reaching.
FAU - Boenink, Marianne
AU  - Boenink M
AD  - Department of Philosophy, Faculty of Behavioural Sciences, University of Twente, 
      P.O. Box 217, 7500 AE Enschede, The Netherlands. m.boenink@utwente.nl
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Med Health Care Philos
JT  - Medicine, health care, and philosophy
JID - 9815900
SB  - IM
MH  - Biomedical Technology/*ethics
MH  - Diagnosis
MH  - Humans
MH  - *Medicine
MH  - Molecular Biology/*ethics
MH  - Monitoring, Physiologic/methods
MH  - *Philosophy, Medical
MH  - Technology Assessment, Biomedical/ethics
PMC - PMC2801843
EDAT- 2009/09/25 06:00
MHDA- 2010/03/20 06:00
CRDT- 2009/09/25 06:00
PHST- 2009/09/25 06:00 [entrez]
PHST- 2009/09/25 06:00 [pubmed]
PHST- 2010/03/20 06:00 [medline]
AID - 10.1007/s11019-009-9223-x [doi]
PST - ppublish
SO  - Med Health Care Philos. 2010 Feb;13(1):11-23. doi: 10.1007/s11019-009-9223-x.


PMID- 19775276
OWN - NLM
STAT- MEDLINE
DCOM- 20100824
LR  - 20220318
IS  - 1523-1739 (Electronic)
IS  - 0888-8892 (Linking)
VI  - 24
IP  - 2
DP  - 2010 Apr
TI  - Motivations for conserving urban biodiversity.
PG  - 432-40
LID - 10.1111/j.1523-1739.2009.01328.x [doi]
AB  - In a time of increasing urbanization, the fundamental value of conserving urban
      biodiversity remains controversial. How much of a fixed budget should be spent on
      conservation in urban versus nonurban landscapes? The answer should depend on the
      goals that drive our conservation actions, yet proponents of urban conservation
      often fail to specify the motivation for protecting urban biodiversity. This is
      an important shortcoming on several fronts, including a missed opportunity to
      make a stronger appeal to those who believe conservation biology should focus
      exclusively on more natural, wilder landscapes. We argue that urban areas do
      offer an important venue for conservation biology, but that we must become better
      at choosing and articulating our goals. We explored seven possible motivations
      for urban biodiversity conservation: preserving local biodiversity, creating
      stepping stones to nonurban habitat, understanding and facilitating responses to 
      environmental change, conducting environmental education, providing ecosystem
      services, fulfilling ethical responsibilities, and improving human well-being. To
      attain all these goals, challenges must be faced that are common to the urban
      environment, such as localized pollution, disruption of ecosystem structure, and 
      limited availability of land. There are, however, also challenges specific only
      to particular goals, meaning that different goals will require different
      approaches and actions. This highlights the importance of specifying the
      motivations behind urban biodiversity conservation. If the goals are unknown,
      progress cannot be assessed.
FAU - Dearborn, Donald C
AU  - Dearborn DC
AD  - Department of Biology, Bucknell University, Lewisburg PA 17837, USA.
      don.dearborn@bucknell.edu
FAU - Kark, Salit
AU  - Kark S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090922
PL  - United States
TA  - Conserv Biol
JT  - Conservation biology : the journal of the Society for Conservation Biology
JID - 9882301
SB  - IM
MH  - Animals
MH  - Antelopes
MH  - *Biodiversity
MH  - *City Planning
MH  - Conservation of Natural Resources/*methods
MH  - Humans
MH  - Motivation
MH  - Population Dynamics
MH  - Socioeconomic Factors
EDAT- 2009/09/25 06:00
MHDA- 2010/08/25 06:00
CRDT- 2009/09/25 06:00
PHST- 2009/09/25 06:00 [entrez]
PHST- 2009/09/25 06:00 [pubmed]
PHST- 2010/08/25 06:00 [medline]
AID - CBI1328 [pii]
AID - 10.1111/j.1523-1739.2009.01328.x [doi]
PST - ppublish
SO  - Conserv Biol. 2010 Apr;24(2):432-40. doi: 10.1111/j.1523-1739.2009.01328.x. Epub 
      2009 Sep 22.


PMID- 19773287
OWN - NLM
STAT- MEDLINE
DCOM- 20100201
LR  - 20091216
IS  - 1468-2060 (Electronic)
IS  - 0003-4967 (Linking)
VI  - 69
IP  - 1
DP  - 2010 Jan
TI  - The time has come to limit the placebo period in rheumatoid arthritis trials to 3
      months: a systematic comparison of 3- and 6-month response rates in trials of
      biological agents.
PG  - 186-92
LID - 10.1136/ard.2009.115832 [doi]
AB  - BACKGROUND: Most registration trials in rheumatoid arthritis (RA) include a
      placebo arm in the setting of an incomplete response to disease-modifying
      antirheumatic treatment (DMARD-IR). A minimum duration of 6 months is required
      despite serious methodological and ethical shortcomings. OBJECTIVE: To study
      whether a 3-month placebo period is sufficient to prove efficacy. METHODS:
      Meta-analysis of placebo- or active control trials of biological agents in
      DMARD-IR RA, comparing the contrast in ACR response between experimental and
      control groups at 3 and 6 months. RESULTS: Twenty trials yielded 15 placebo and
      18 active control contrasts (>10,000 patients). At 3 months active treatment
      showed a highly significant contrast with placebo for ACR20 and ACR50 in every
      instance. As all groups improved further the mean contrast at 6 months was
      unchanged. For ACR70 the contrast was clearly greater at 6 months owing to
      further improvement only in the experimental groups. In active control trials
      contrasts were smaller, and for ACR50 and ACR70 these decreased somewhat owing to
      "catch-up" responses in the control groups. CONCLUSION: The placebo phase of
      registration trials for RA can be limited to 3 months. An accompanying viewpoint 
      proposes that patients receiving placebo should then be switched to standard of
      care, allowing a more valid and comprehensive assessment, including safety.
FAU - Boers, M
AU  - Boers M
AD  - Department of Epidemiology and Biostatistics, VU University Medical Centre, PK 6Z
      165, PO Box 7057, 1007 MB Amsterdam, The Netherlands. eb@vumc.nl
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Meta-Analysis
PL  - England
TA  - Ann Rheum Dis
JT  - Annals of the rheumatic diseases
JID - 0372355
RN  - 0 (Antirheumatic Agents)
RN  - 0 (Immunologic Factors)
RN  - 0 (Placebos)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
CIN - Ann Rheum Dis. 2010 Jan;69(1):1-3. PMID: 20007619
CIN - Ann Rheum Dis. 2010 Jan;69(1):4-6. PMID: 20007620
MH  - Antirheumatic Agents/*administration & dosage
MH  - Arthritis, Rheumatoid/*drug therapy
MH  - Drug Administration Schedule
MH  - Humans
MH  - Immunologic Factors/*administration & dosage
MH  - Placebos/*administration & dosage
MH  - Randomized Controlled Trials as Topic/*methods
MH  - Research Design
MH  - Time Factors
MH  - Treatment Failure
MH  - Treatment Outcome
MH  - Tumor Necrosis Factor-alpha/antagonists & inhibitors
EDAT- 2009/09/24 06:00
MHDA- 2010/02/02 06:00
CRDT- 2009/09/24 06:00
PHST- 2009/09/24 06:00 [entrez]
PHST- 2009/09/24 06:00 [pubmed]
PHST- 2010/02/02 06:00 [medline]
AID - ard.2009.115832 [pii]
AID - 10.1136/ard.2009.115832 [doi]
PST - ppublish
SO  - Ann Rheum Dis. 2010 Jan;69(1):186-92. doi: 10.1136/ard.2009.115832.


PMID- 19773218
OWN - NLM
STAT- MEDLINE
DCOM- 20101006
LR  - 20220317
IS  - 1468-2044 (Electronic)
IS  - 0003-9888 (Linking)
VI  - 95
IP  - 8
DP  - 2010 Aug
TI  - Consequences of the Chicago consensus on disorders of sex development (DSD):
      current practices in Europe.
PG  - 618-23
LID - 10.1136/adc.2009.163840 [doi]
AB  - OBJECTIVE: To assess clinical management of disorders of sex development (DSD)
      subsequent to recommendations issued in the 2006 Consensus Statement. DESIGN:
      Online questionnaire and audit of DSD literature. SETTING: Invitation to complete
      a 28-item online questionnaire and a 12-item follow-up questionnaire, both
      assessing current clinic statistics and clinical management of DSD. PARTICIPANTS:
      Paediatric endocrinologists from 60 medical centres representing 23 European
      countries. MAIN OUTCOME MEASURES: Clinic activity, multidisciplinary team
      composition, provision of psychological support services, incidence of feminising
      clitoroplasty and use of diagnostic algorithms and newly proposed nomenclature.
      ANALYSES: Data are reported in terms of percentages with respect to
      implementation of recommendations outlined in the Consensus Statement. chi(2) was
      used to analyse changes in nomenclature reported in the literature. RESULTS: 60
      centres reported on management of an average of 97.3 (range 8-374) patients per
      year, totalling approximately 6000. The mean number of new referrals in the
      previous year was 23.27 (range 8-100). 57% of centres regularly included the
      services of recommended paediatric subspecialists: paediatric endocrinologist,
      paediatric surgeon/urologist, plastic surgeon, paediatric
      psychiatrist/psychologist, gynaecologist, clinical geneticist, histopathologist
      and neonatologist; 35% reported providing these and additional services of
      endocrine and surgical nurses, a social worker and a medical ethicist.
      Additionally, 95% of centres reported offering primary psychological support
      services (either child psychiatrist or psychologist). 65% of centres reported
      using a diagnostic algorithm, and 83.3% supported the development of a
      standardised algorithm. 52% and 44.8% of centres reported having performed fewer 
      or similar numbers, respectively, of clitoroplasties than in previous years and
      only 3.4% reported an increase. Finally, 100% of respondents reported using the
      newly proposed terminology. Likewise, an audit of the literature reflected a
      recent reduction in usage of the non-preferred historical terminology.
      CONCLUSIONS: There is evidence that the majority of European DSD centres have
      implemented policies and procedures in accordance with the recommendations issued
      by the 2006 Consensus Group. These findings represent a change in practice with
      the collaborative goal of improved patient care.
FAU - Pasterski, V
AU  - Pasterski V
AD  - Department of Paediatrics, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.
      vp265@medschl.cam.ac.uk
FAU - Prentice, P
AU  - Prentice P
FAU - Hughes, I A
AU  - Hughes IA
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20090922
PL  - England
TA  - Arch Dis Child
JT  - Archives of disease in childhood
JID - 0372434
SB  - IM
MH  - Algorithms
MH  - Child
MH  - Child Health Services/organization & administration
MH  - Consensus Development Conferences as Topic
MH  - Delivery of Health Care/*organization & administration
MH  - Disorders of Sex Development/diagnosis/epidemiology/*therapy
MH  - Europe/epidemiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Mental Health Services/organization & administration
MH  - Patient Care Team/organization & administration
MH  - Professional Practice/*organization & administration
MH  - Reconstructive Surgical Procedures/statistics & numerical data
MH  - Terminology as Topic
EDAT- 2009/09/24 06:00
MHDA- 2010/10/07 06:00
CRDT- 2009/09/24 06:00
PHST- 2009/09/24 06:00 [entrez]
PHST- 2009/09/24 06:00 [pubmed]
PHST- 2010/10/07 06:00 [medline]
AID - adc.2009.163840 [pii]
AID - 10.1136/adc.2009.163840 [doi]
PST - ppublish
SO  - Arch Dis Child. 2010 Aug;95(8):618-23. doi: 10.1136/adc.2009.163840. Epub 2009
      Sep 22.


PMID- 19771439
OWN - NLM
STAT- MEDLINE
DCOM- 20100707
LR  - 20100305
IS  - 1432-0711 (Electronic)
IS  - 0932-0067 (Linking)
VI  - 281
IP  - 4
DP  - 2010 Apr
TI  - Ovarian tissue cryopreservation for non-malignant indications.
PG  - 735-9
LID - 10.1007/s00404-009-1224-8 [doi]
AB  - BACKGROUND: Ovarian tissue cryopreservation (OTC) is not restricted to patients
      suffering from malignancies. Benign haematopoietic diseases such as autoimmune
      diseases and others have been mentioned to be feasible indications. The aim of
      our study was to demonstrate that surgery for OTC is a safe procedure for
      fertility preservation in patients with non-malignant diseases. METHODS: In a
      retrospective cohort study intra- and postoperative courses were evaluated.
      Histological examination of one random ovarian cortical slice was performed to
      determine the presence of primordial follicles. Immediately after the excision,
      microbiological culture techniques from swabs were taken from all slices.
      RESULTS: Seven of 85 patients (8.2%) have undergone surgery for OTC for
      non-malignant indications. All patients had an uncomplicated intraoperative
      course. A median number of 12 cortical stripes were excised and cryopreserved
      (range 7-17). Only for one patient an adverse event was found which was not
      related to laparoscopy for OTC. All patients having undergone routine laparoscopy
      for OTC only could be released from hospital on the first postoperative day.
      Selective microbiological tests showed negative results in all cases.
      Histological examinations revealed intact ovarian tissue with primordial
      follicles in 6/7 patients. CONCLUSION: Whether surgery for OTC in patients with
      non-malignant indications is feasible from an ethical point of view remains open.
      However, laparoscopy for ovarian tissue harvesting is a safe procedure for
      patients undergoing cytotoxic treatment for benign diseases.
FAU - Ott, Johannes
AU  - Ott J
AD  - Department of Gynaecologic Endocrinology and Reproductive Medicine, Medical
      University of Vienna, Wahringer Gurtel 18-20, Vienna, Austria.
      johannes.ott@meduniwien.ac.at
FAU - Nouri, Kazem
AU  - Nouri K
FAU - Stogbauer, Lucija
AU  - Stogbauer L
FAU - Fischer, Eva M
AU  - Fischer EM
FAU - Lipovac, Markus
AU  - Lipovac M
FAU - Promberger, Regina
AU  - Promberger R
FAU - Huber, Johannes C
AU  - Huber JC
FAU - Mayerhofer, Klaus
AU  - Mayerhofer K
LA  - eng
PT  - Journal Article
DEP - 20090922
PL  - Germany
TA  - Arch Gynecol Obstet
JT  - Archives of gynecology and obstetrics
JID - 8710213
SB  - IM
MH  - Adult
MH  - *Cryopreservation
MH  - Female
MH  - *Fertility
MH  - Humans
MH  - Laparoscopy
MH  - Ovary/cytology/microbiology/*surgery
MH  - Postoperative Period
MH  - Retrospective Studies
MH  - Young Adult
EDAT- 2009/09/23 06:00
MHDA- 2010/07/08 06:00
CRDT- 2009/09/23 06:00
PHST- 2009/05/21 00:00 [received]
PHST- 2009/09/08 00:00 [accepted]
PHST- 2009/09/23 06:00 [entrez]
PHST- 2009/09/23 06:00 [pubmed]
PHST- 2010/07/08 06:00 [medline]
AID - 10.1007/s00404-009-1224-8 [doi]
PST - ppublish
SO  - Arch Gynecol Obstet. 2010 Apr;281(4):735-9. doi: 10.1007/s00404-009-1224-8. Epub 
      2009 Sep 22.


PMID- 19771410
OWN - NLM
STAT- MEDLINE
DCOM- 20100421
LR  - 20211020
IS  - 1432-1238 (Electronic)
IS  - 0342-4642 (Linking)
VI  - 36
IP  - 2
DP  - 2010 Feb
TI  - Fellows' in intensive care medicine views on professionalism and how they learn
      it.
PG  - 296-303
LID - 10.1007/s00134-009-1644-8 [doi]
AB  - INTRODUCTION: The emphasis on the importance of professionalism in a recent
      CoBaTrICE-IT paper was impressive. However, insight into the elements of
      professionalism as perceived relevant for intensivists from the fellows' view,
      and how these are taught and learned, is limited. OBJECTIVES AND METHODS: A
      nationwide study was performed in 2007-2008. All ICM fellows (n = 90) were sent a
      questionnaire containing the following questions regarding training in
      professionalism (7-point Likert scale (1 = very inadequate, 7 = very adequate)): 
      which are the elements perceived to be important in intensivists'' daily practice
      (38 items, cat. I)? Which methods of learning and teaching are recognised (16
      items, cat. II)? Which methods of teaching and learning are considered especially
      useful (16 items, cat. III)? Finally, the perceived quantity and quality of
      formal and informal learning methods, as well as the responsible organisational
      body was studied. Data were analysed using SPSS 15.0. RESULTS: Response was 75.5 
      % (n = 68), mean age 34 years. Regarding Elements, scores on virtually all items 
      were high. The factor 'striving for excellence' explained half the variance. Two 
      other aspects, 'Teamwork' and 'Dealing with ethical dilemmas', were identified.
      Regarding Methods, three dimensions, 'formal curriculum'', 'private and academic 
      experiences' and 'role modelling', proved important. The factor 'formal
      curriculum' explained most of the variance. Regarding Usefulness the same
      factors, now mainly explained by the factor Private and academic experiences,
      emerged with variance. In both categories the items 'observations in daily
      practice' and 'watching television programmes like ER and House' were the
      highest- and lowest-scoring items (5.99 and 5.81, and 2.69 and 2.49,
      respectively). Mean scores regarding the quantity of formal and informal teaching
      were 4.06 and 4.58 (range 1.841 and 1.519). For the quality of teaching, the
      figures were 4.22 and 4.52 (range 1.659 and 1.560, respectively). 54 suggestions 
      for improvement of teaching were documented. The need for some form of formal
      teaching of professionalism aspects as well as for feedback was most frequently
      mentioned (n = 19 and 16). The local training centres are considered and should
      remain pivotal for teaching professionalism issues (n = 17 and 28). CONCLUSIONS: 
      Almost all elements of professionalism were considered relevant to intensivists' 
      daily practice. Although formal teaching methods regarding professionalism
      aspects are easily recognised in daily practice, learning by personal experiences
      and informal ways quantitatively plays a more important, and more valued role.
      Qualitative comments, nevertheless, stress the need for providing and receiving
      (solicited and unsolicited) feedback, thereby requesting expansion of formal
      teaching methods. The local training centres (should continue to) play a major
      role in teaching professionalism, although an additional role for the
      (inter)national intensive care organisations remains.
FAU - van Mook, Walther N K A
AU  - van Mook WN
AD  - Department of Intensive Care, Maastricht University Medical Centre, P. Debeyelaan
      25, 6202 AZ, Maastricht, The Netherlands. w.van.mook@mumc.nl
FAU - de Grave, Willem S
AU  - de Grave WS
FAU - Gorter, Simone L
AU  - Gorter SL
FAU - Muijtjens, Arno M M
AU  - Muijtjens AM
FAU - Zwaveling, Jan Harm
AU  - Zwaveling JH
FAU - Schuwirth, Lambert W
AU  - Schuwirth LW
FAU - van der Vleuten, Cees P M
AU  - van der Vleuten CP
LA  - eng
PT  - Journal Article
DEP - 20090922
PL  - United States
TA  - Intensive Care Med
JT  - Intensive care medicine
JID - 7704851
SB  - IM
MH  - Adult
MH  - *Clinical Competence
MH  - *Critical Care
MH  - Curriculum
MH  - Humans
MH  - Internship and Residency
MH  - *Learning
MH  - Surveys and Questionnaires
MH  - Workforce
PMC - PMC2809310
EDAT- 2009/09/23 06:00
MHDA- 2010/04/22 06:00
CRDT- 2009/09/23 06:00
PHST- 2009/05/01 00:00 [received]
PHST- 2009/08/04 00:00 [accepted]
PHST- 2009/09/23 06:00 [entrez]
PHST- 2009/09/23 06:00 [pubmed]
PHST- 2010/04/22 06:00 [medline]
AID - 10.1007/s00134-009-1644-8 [doi]
PST - ppublish
SO  - Intensive Care Med. 2010 Feb;36(2):296-303. doi: 10.1007/s00134-009-1644-8. Epub 
      2009 Sep 22.


PMID- 19766436
OWN - NLM
STAT- MEDLINE
DCOM- 20110307
LR  - 20191210
IS  - 1873-5134 (Electronic)
IS  - 0738-3991 (Linking)
VI  - 79
IP  - 1
DP  - 2010 Apr
TI  - Development and use of a decision aid for communication with hospitalized
      patients about cardiopulmonary resuscitation preference.
PG  - 130-3
LID - 10.1016/j.pec.2009.08.002 [doi]
AB  - OBJECTIVE: To develop and evaluate a decision aid related to CPR decision-making 
      for hospitalized patients. METHODS: The development of the decision aid was
      guided by published recommendations; physicians, nurses, and a clinical ethicist 
      were involved in the process. In-patients over age 55 with serious illnesses and 
      their family were involved in pre-testing and evaluation. RESULTS: Twenty-five
      patients and 11 family members participated. The majority (23/25, 92% of
      patients, 7/11, 64% of family) reported the information in the decision aid was
      'Very' or 'Extremely' helpful in decisions. More than 70% of patients and family 
      considered the aid to be "acceptable." The decision aid did not appear to bias
      towards or away from preferences for CPR. Participants did not report significant
      burden with use (median score 2/10; 1=none, 10=extremely upsetting). All patients
      and 10 family members recommended the aid be available to all patients.
      CONCLUSION: The decision aid was felt to be acceptable, feasible, and useful by
      participants. Future research should evaluate the impact of the decision aid on
      outcomes including quality of decision-making. PRACTICE IMPLICATIONS: The
      decision aid can be used to assist with CPR decision-making with seriously ill
      hospitalized patients. It is available for use on the CARENET website.
CI  - 2009 Elsevier Ireland Ltd. All rights reserved.
FAU - Frank, Christopher
AU  - Frank C
AD  - Department of Medicine, Queen's University, Ontario, Canada.
      frankc@providencecare.ca
FAU - Pichora, Deborah
AU  - Pichora D
FAU - Suurdt, Jeannette
AU  - Suurdt J
FAU - Heyland, Daren
AU  - Heyland D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20090918
PL  - Ireland
TA  - Patient Educ Couns
JT  - Patient education and counseling
JID - 8406280
MH  - Aged
MH  - Cardiopulmonary Resuscitation/*methods/statistics & numerical data
MH  - Decision Making
MH  - *Decision Support Techniques
MH  - Feasibility Studies
MH  - Female
MH  - Health Education/*methods/statistics & numerical data
MH  - Hospital Communication Systems/organization & administration/*statistics &
      numerical data
MH  - Humans
MH  - Male
MH  - Medical Staff, Hospital
MH  - Nursing Staff, Hospital
MH  - Ontario
MH  - Patient Education as Topic/*methods/statistics & numerical data
MH  - Program Development
MH  - Program Evaluation
MH  - Quality of Health Care
MH  - Surveys and Questionnaires
EDAT- 2009/09/22 06:00
MHDA- 2011/03/08 06:00
CRDT- 2009/09/22 06:00
PHST- 2008/11/19 00:00 [received]
PHST- 2009/07/30 00:00 [revised]
PHST- 2009/08/06 00:00 [accepted]
PHST- 2009/09/22 06:00 [entrez]
PHST- 2009/09/22 06:00 [pubmed]
PHST- 2011/03/08 06:00 [medline]
AID - S0738-3991(09)00365-6 [pii]
AID - 10.1016/j.pec.2009.08.002 [doi]
PST - ppublish
SO  - Patient Educ Couns. 2010 Apr;79(1):130-3. doi: 10.1016/j.pec.2009.08.002. Epub
      2009 Sep 18.


PMID- 19765333
OWN - NLM
STAT- MEDLINE
DCOM- 20100315
LR  - 20091223
IS  - 1469-8161 (Electronic)
IS  - 0031-1820 (Linking)
VI  - 137
IP  - 1
DP  - 2010 Jan
TI  - Genetic influence on the kinetics and associated pathology of the early stage
      (intestinal-hepatic) migration of Ascaris suum in mice.
PG  - 173-85
LID - 10.1017/S0031182009990850 [doi]
AB  - The generative mechanism(s) of aggregation and predisposition to Ascaris
      lumbricoides and A. suum infections in their host population are currently
      unknown and difficult to elucidate in humans and pigs for ethical/logistical
      reasons. A recently developed, optimized murine model based on 2 inbred strains, 
      putatively susceptible (C57BL/6j) and resistant (CBA/Ca) to infection, was
      exploited to elucidate further the basis of the contrasting parasite burdens,
      most evident at the pulmonary stage. We explored the kinetics of early infection,
      focusing on the composite lobes of the liver and lung, over the first 8 days in
      an effort to achieve a more detailed understanding of the larval dispersal over
      time and the point at which worm burdens diverge. Larval recoveries showed a
      heterogenous distribution among the lobes of the lungs, being higher in the right
      lung of both strains, and in the susceptible strain larvae accumulating
      preferentially in 2 (caudal and middle) of the 4 lobes. Total larval burdens in
      these 2 lobes were largely responsible for the higher worm burdens in the
      susceptible strain. While total lung larval recoveries significantly differed
      between mouse strains, a difference in liver larval burdens was not observed.
      However, an earlier intense inflammatory response coupled with more rapid tissue 
      repair in the hepatic lobes was observed in CBA/Ca mice, in contrast to C57BL/6j 
      mice, and it is possible that these processes are responsible for restricting
      onward pulmonary larval migration in the resistant genotype.
FAU - Dold, C
AU  - Dold C
AD  - Department of Zoology, School of Natural Sciences, Trinity College Dublin, Dublin
      2, Ireland. cdold@tcd.ie
FAU - Cassidy, J P
AU  - Cassidy JP
FAU - Stafford, P
AU  - Stafford P
FAU - Behnke, J M
AU  - Behnke JM
FAU - Holland, C V
AU  - Holland CV
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090921
PL  - England
TA  - Parasitology
JT  - Parasitology
JID - 0401121
SB  - IM
MH  - Animals
MH  - Ascariasis/*genetics/parasitology/*pathology
MH  - Ascaris suum/growth & development/*pathogenicity/physiology
MH  - *Disease Models, Animal
MH  - Disease Susceptibility
MH  - Humans
MH  - Intestines/*parasitology
MH  - Kinetics
MH  - Larva/physiology
MH  - Liver/*parasitology
MH  - Lung/parasitology/pathology
MH  - Lung Diseases/parasitology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred CBA
MH  - Movement
MH  - Time Factors
EDAT- 2009/09/22 06:00
MHDA- 2010/03/17 06:00
CRDT- 2009/09/22 06:00
PHST- 2009/09/22 06:00 [entrez]
PHST- 2009/09/22 06:00 [pubmed]
PHST- 2010/03/17 06:00 [medline]
AID - S0031182009990850 [pii]
AID - 10.1017/S0031182009990850 [doi]
PST - ppublish
SO  - Parasitology. 2010 Jan;137(1):173-85. doi: 10.1017/S0031182009990850. Epub 2009
      Sep 21.


PMID- 19763671
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20211020
IS  - 1863-4362 (Electronic)
IS  - 0021-1265 (Linking)
VI  - 179
IP  - 1
DP  - 2010 Mar
TI  - Preliminary analysis of demographics and learning attributes of graduate entry
      medical students.
PG  - 95-8
LID - 10.1007/s11845-009-0428-z [doi]
AB  - INTRODUCTION: Students entering university are empowered to move towards
      self-directed professional learning and beyond didactic tuition. Graduate entry
      medical (GEM) students have prior experience of this transition from pedagogical 
      to androgogical learning. We aimed to assess the demographics and learning
      attributes of GEM students. METHODS: Ethical exemption was awarded. The short
      version of the approaches and study skills inventory for students and the
      learning style questionnaire were distributed to GEM students during semester 1, 
      2008. RESULTS: Response rate was 84% (n = 32). Fifty percent of responders had
      graduated in 2008 (22%) or 2007 (28%). Seventy-five percent had a background in
      basic science (56%) or an allied health profession (19%). The predominant
      learning approach is a combination of deep and strategic. The predominant
      learning style is reflective. CONCLUSIONS: Our preliminary analysis reveals GEM
      students to exhibit a mature approach to learning and the requisite learning
      style to achieve academic and clinical success.
FAU - Fanning, D M
AU  - Fanning DM
AD  - Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland.
      fanningdee@yahoo.co.uk
FAU - Chadwick, G
AU  - Chadwick G
LA  - eng
PT  - Journal Article
DEP - 20090911
PL  - Ireland
TA  - Ir J Med Sci
JT  - Irish journal of medical science
JID - 7806864
SB  - IM
MH  - Adult
MH  - Data Collection
MH  - Demography
MH  - Education, Medical, Graduate/*statistics & numerical data
MH  - *Educational Measurement
MH  - Educational Status
MH  - Female
MH  - Humans
MH  - Ireland
MH  - *Learning
MH  - Male
MH  - Statistics as Topic
MH  - Students, Medical/*statistics & numerical data
MH  - Surveys and Questionnaires
MH  - Time Factors
MH  - Young Adult
EDAT- 2009/09/19 06:00
MHDA- 2011/06/03 06:00
CRDT- 2009/09/19 06:00
PHST- 2009/02/16 00:00 [received]
PHST- 2009/08/16 00:00 [accepted]
PHST- 2009/09/19 06:00 [entrez]
PHST- 2009/09/19 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
AID - 10.1007/s11845-009-0428-z [doi]
PST - ppublish
SO  - Ir J Med Sci. 2010 Mar;179(1):95-8. doi: 10.1007/s11845-009-0428-z. Epub 2009 Sep
      11.


PMID- 19763657
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1865-3499 (Electronic)
IS  - 1555-8932 (Linking)
VI  - 5
IP  - 1
DP  - 2010 Mar
TI  - Personalised food: how personal is it?
PG  - 51-3
LID - 10.1007/s12263-009-0139-0 [doi]
AB  - Consumer goods became increasingly personalised, particularly during the last
      half of the 20th century. Foods and food products have been added a new flavour
      in this consumer trends with increasingly personalised values of convenience,
      cost, packaging, and taste. Now functional food industry is ready to take its
      next venture in a relatively new domain personalising health. Whether the goal of
      matching foods to individual genotypes to improve the health of those individuals
      can be attained, and personalised nutrigenomic foods enter the world's food
      markets, depends on numerous hurdles being overcome: some scientific in nature,
      some technical and others related to consumer, market or ethical issues. Public
      adoption of new technologies is an important determinant for their success. Many 
      of the drivers behind the trend in personalisation of food are now known,
      particularly ethical, legal and social issues (ELSI) are the major drivers.
      Future development in the field of nutrigenomics undoubtedly will place its
      seemingly huge potential in better perspective. Thus, the agriculture and food
      enterprise has an extraordinary opportunity to link individuals with foods that
      are personalised for their health.
FAU - Ghosh, Dilip
AU  - Ghosh D
AD  - Nutriconnect, Sydney, NSW 2154 Australia.
LA  - eng
PT  - Journal Article
DEP - 20090911
PL  - Germany
TA  - Genes Nutr
JT  - Genes & nutrition
JID - 101280108
PMC - PMC2820193
OTO - NOTNLM
OT  - Consumer
OT  - Functional food
OT  - Nutrigenomics
OT  - Nutrition
OT  - Personalised food
EDAT- 2009/09/19 06:00
MHDA- 2009/09/19 06:01
CRDT- 2009/09/19 06:00
PHST- 2009/07/20 00:00 [received]
PHST- 2009/08/03 00:00 [accepted]
PHST- 2009/09/19 06:00 [entrez]
PHST- 2009/09/19 06:00 [pubmed]
PHST- 2009/09/19 06:01 [medline]
AID - 10.1007/s12263-009-0139-0 [doi]
PST - ppublish
SO  - Genes Nutr. 2010 Mar;5(1):51-3. doi: 10.1007/s12263-009-0139-0. Epub 2009 Sep 11.


PMID- 19760114
OWN - NLM
STAT- MEDLINE
DCOM- 20100603
LR  - 20211020
IS  - 1573-7292 (Electronic)
IS  - 1389-9600 (Linking)
VI  - 9
IP  - 1
DP  - 2010 Mar
TI  - The challenge of developmentally appropriate care: predictive genetic testing in 
      young people for familial adenomatous polyposis.
PG  - 27-35
LID - 10.1007/s10689-009-9294-0 [doi]
AB  - Predictive genetic tests for familial adenomatous polyposis (FAP) are routinely
      offered to young people during early adolescence. While this is not
      controversial, due to the medical benefit conferred by the test, it is
      nonetheless challenging as a consequence of the stage of life of the young
      people, and the simultaneous involvement of multiple family members. Despite
      these challenges, it is possible to ensure that the test is offered in such a way
      that it actively acknowledges and facilitates young people's developing autonomy 
      and psychosocial well-being. In this paper we present findings from ten in-depth 
      interviews with young people who have undergone predictive genetic testing for
      FAP (four male, six female; five gene-positive, five gene-negative; aged 10-17
      years at the time of their predictive test; aged 12-25 years at the time of their
      research interview). We present five themes that emerged from the interviews
      which highlight key ethical challenges associated with such testing. These are:
      (1) the significance of the test; (2) young people's lack of involvement in the
      decision to be tested; (3) young people's limited understanding; (4) provision of
      the blood test at the first visit; and (5) group testing of family members. We
      draw on these themes to make eight recommendations for future practice. Together,
      these recommendations highlight the importance of providing developmentally
      appropriate care to young people undergoing predictive genetic testing for FAP.
FAU - Duncan, Rony E
AU  - Duncan RE
AD  - Murdoch Children's Research Institute, Flemington Road, Parkville, VC, 3052,
      Australia. rony.duncan@mcri.edu.au
FAU - Gillam, Lynn
AU  - Gillam L
FAU - Savulescu, Julian
AU  - Savulescu J
FAU - Williamson, Robert
AU  - Williamson R
FAU - Rogers, John G
AU  - Rogers JG
FAU - Delatycki, Martin B
AU  - Delatycki MB
LA  - eng
PT  - Journal Article
DEP - 20090917
PL  - Netherlands
TA  - Fam Cancer
JT  - Familial cancer
JID - 100898211
SB  - IM
MH  - Adenomatous Polyposis Coli/*genetics
MH  - Adolescent
MH  - Attitude to Health
MH  - Colonic Polyps/drug therapy/epidemiology/genetics
MH  - Family Health
MH  - Female
MH  - Forecasting
MH  - Genetic Counseling/*statistics & numerical data
MH  - Genetic Predisposition to Disease/*genetics
MH  - *Genetic Testing
MH  - Government Regulation
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Nurse-Patient Relations
MH  - Patient Compliance/statistics & numerical data
MH  - Physician's Role
MH  - *Quality of Life
MH  - Risk Assessment/ethics
MH  - Self Concept
MH  - *Surveys and Questionnaires
EDAT- 2009/09/18 06:00
MHDA- 2010/06/04 06:00
CRDT- 2009/09/18 06:00
PHST- 2009/03/10 00:00 [received]
PHST- 2009/08/30 00:00 [accepted]
PHST- 2009/09/18 06:00 [entrez]
PHST- 2009/09/18 06:00 [pubmed]
PHST- 2010/06/04 06:00 [medline]
AID - 10.1007/s10689-009-9294-0 [doi]
PST - ppublish
SO  - Fam Cancer. 2010 Mar;9(1):27-35. doi: 10.1007/s10689-009-9294-0. Epub 2009 Sep
      17.


PMID- 19758731
OWN - NLM
STAT- MEDLINE
DCOM- 20100610
LR  - 20191210
IS  - 1532-2793 (Electronic)
IS  - 0260-6917 (Linking)
VI  - 30
IP  - 4
DP  - 2010 May
TI  - Improving cross-cultural care and antiracism in nursing education: a literature
      review.
PG  - 314-20
LID - 10.1016/j.nedt.2009.08.007 [doi]
AB  - PURPOSE: To appraise through literature review the available research evidence to
      guide teaching and learning regarding cross-cultural care for nursing students.
      Cross-cultural education of nurses with a focus on both culture and antiracism is
      one way of promoting ethical and effective cross-cultural health systems for
      people from culturally diverse backgrounds. Although cross-cultural care has long
      been recognised as necessary to nursing education there is no clear consensus
      regarding how it is to be taught or which theoretical perspectives should
      underpin this teaching. FINDINGS: Current literature supports the effectiveness
      of cross-cultural teaching interventions in promoting cultural competence and in 
      facilitating attitudinal and belief changes in nursing students. The literature
      further suggests that racism persists in some students following participation in
      cross-cultural education and that there is a paucity of theory, teaching
      interventions and evaluations addressing antiracism. CONCLUSIONS: Cross-cultural 
      education alone is insufficient to combat racism. Cross-cultural education
      focused on both cultural competence and antiracism is necessary to promote
      effective cultural care in nursing students.
CI  - Copyright 2009 Elsevier Ltd. All rights reserved.
FAU - Allen, Jacqui
AU  - Allen J
AD  - School of Nursing, Deakin University, 221 Burwood Highway, Burwood, Victoria
      3125, Australia. jacqui.allen@deakin.edu.au
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20090915
PL  - Scotland
TA  - Nurse Educ Today
JT  - Nurse education today
JID - 8511379
MH  - Attitude of Health Personnel
MH  - Cultural Competency/*education
MH  - *Cultural Diversity
MH  - *Curriculum
MH  - Education, Nursing, Baccalaureate/*organization & administration
MH  - Health Knowledge, Attitudes, Practice
MH  - Health Services Needs and Demand
MH  - Humans
MH  - Nursing Education Research
MH  - Outcome Assessment, Health Care
MH  - *Prejudice
MH  - Program Evaluation
MH  - Quality of Health Care
MH  - Research Design
MH  - Stereotyping
MH  - Students, Nursing/psychology
RF  - 42
EDAT- 2009/09/18 06:00
MHDA- 2010/06/11 06:00
CRDT- 2009/09/18 06:00
PHST- 2009/01/12 00:00 [received]
PHST- 2009/07/23 00:00 [revised]
PHST- 2009/08/12 00:00 [accepted]
PHST- 2009/09/18 06:00 [entrez]
PHST- 2009/09/18 06:00 [pubmed]
PHST- 2010/06/11 06:00 [medline]
AID - S0260-6917(09)00163-4 [pii]
AID - 10.1016/j.nedt.2009.08.007 [doi]
PST - ppublish
SO  - Nurse Educ Today. 2010 May;30(4):314-20. doi: 10.1016/j.nedt.2009.08.007. Epub
      2009 Sep 15.


PMID- 19758729
OWN - NLM
STAT- MEDLINE
DCOM- 20100610
LR  - 20151119
IS  - 1532-2793 (Electronic)
IS  - 0260-6917 (Linking)
VI  - 30
IP  - 4
DP  - 2010 May
TI  - Researching student absence: methodological challenges and ethical issues.
PG  - 291-5
LID - 10.1016/j.nedt.2009.08.003 [doi]
AB  - This article describes the challenges encountered in a research project aiming to
      explore non-attendance from the perspective of absent students. These students
      are nursing students in a Faculty of Health and Social Care, but the issues
      raised here are of wider interest. Although attendance at the sessions monitored 
      for this project is stated to be compulsory, there is typically a non-attendance 
      rate of around 20%. Previous studies within the Faculty have reported positively 
      on students' views of the sessions, but have relied on data collected from
      students present in the university and attending the sessions. We felt it was
      important to correct this imbalance with the views of those students who do not
      attend. We hoped to access the views of students not present in the university by
      means of telephone interviews, carried out by a researcher independent from the
      course management. This article explores a number of ethical and methodological
      issues which arose from the research, focusing on the difficulties in gaining
      informed consent from students who do not attend, and the challenges in moving
      beyond surface responses to questions on reasons for non-attendance.
CI  - Copyright 2009 Elsevier Ltd. All rights reserved.
FAU - Young, Pat
AU  - Young P
AD  - Faculty of Health and Life Sciences, University of the West of England, Bristol, 
      Blackberry Hill, Bristol BS16 1DD, UK. pat2.young@uwe.ac.uk
FAU - Yates, Sue
AU  - Yates S
FAU - Rickaby, Caroline
AU  - Rickaby C
FAU - Snelling, Paul
AU  - Snelling P
FAU - Lipscomb, Martin
AU  - Lipscomb M
FAU - Lockyer, Lesley
AU  - Lockyer L
LA  - eng
PT  - Journal Article
DEP - 20090915
PL  - Scotland
TA  - Nurse Educ Today
JT  - Nurse education today
JID - 8511379
MH  - *Absenteeism
MH  - *Attitude of Health Personnel
MH  - Clinical Competence
MH  - Data Collection/ethics/methods
MH  - Education, Nursing, Baccalaureate
MH  - Employment
MH  - England
MH  - Feedback, Psychological
MH  - Humans
MH  - Informed Consent/ethics/psychology
MH  - Interviews as Topic
MH  - Mandatory Programs
MH  - Motivation
MH  - *Nursing Methodology Research/ethics/methods
MH  - Research Design
MH  - Research Subjects/psychology
MH  - Students, Nursing/*psychology
MH  - Surveys and Questionnaires
EDAT- 2009/09/18 06:00
MHDA- 2010/06/11 06:00
CRDT- 2009/09/18 06:00
PHST- 2009/01/08 00:00 [received]
PHST- 2009/07/07 00:00 [revised]
PHST- 2009/08/03 00:00 [accepted]
PHST- 2009/09/18 06:00 [entrez]
PHST- 2009/09/18 06:00 [pubmed]
PHST- 2010/06/11 06:00 [medline]
AID - S0260-6917(09)00150-6 [pii]
AID - 10.1016/j.nedt.2009.08.003 [doi]
PST - ppublish
SO  - Nurse Educ Today. 2010 May;30(4):291-5. doi: 10.1016/j.nedt.2009.08.003. Epub
      2009 Sep 15.


PMID- 19757190
OWN - NLM
STAT- MEDLINE
DCOM- 20110210
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 16
IP  - 3
DP  - 2010 Sep
TI  - Between same-sex marriages and the Large Hadron Collider: making sense of the
      precautionary principle.
PG  - 591-610
LID - 10.1007/s11948-009-9165-y [doi]
AB  - The Precautionary Principle is a guide to coping with scientific uncertainties in
      the assessment and management of risks. In recent years, it has moved to the
      forefront of debates in policy and applied ethics, becoming a key normative tool 
      in policy discussions in such diverse areas as medical and scientific research,
      health and safety regulation, environmental regulation, product development,
      international trade, and even judicial review. The principle has attracted
      critics who claim that it is fundamentally incoherent, too vague to guide policy,
      and makes demands that are logically and scientifically impossible. In this paper
      we will answer these criticisms by formulating guidelines for its application
      that ensure its coherence as a useful normative guide in applied and policy
      ethics debates. We will also provide analyses of cases that demonstrate how our
      version of the principle functions in practice.
FAU - Petrenko, Anton
AU  - Petrenko A
AD  - Department of Philosophy, York University, Toronto, ON, M3J-1P3, Canada.
      anton_letters@hotmail.com
FAU - McArthur, Dan
AU  - McArthur D
LA  - eng
PT  - Journal Article
DEP - 20090912
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Homosexuality
MH  - Humans
MH  - Marriage/legislation & jurisprudence
MH  - Physics/legislation & jurisprudence
MH  - *Policy Making
MH  - Risk Assessment/*methods
MH  - Safety/*legislation & jurisprudence
MH  - Science/ethics/*legislation & jurisprudence
MH  - *Uncertainty
MH  - United States
EDAT- 2009/09/17 06:00
MHDA- 2011/02/11 06:00
CRDT- 2009/09/17 06:00
PHST- 2009/02/28 00:00 [received]
PHST- 2009/08/14 00:00 [accepted]
PHST- 2009/09/17 06:00 [entrez]
PHST- 2009/09/17 06:00 [pubmed]
PHST- 2011/02/11 06:00 [medline]
AID - 10.1007/s11948-009-9165-y [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2010 Sep;16(3):591-610. doi: 10.1007/s11948-009-9165-y. Epub 2009
      Sep 12.


PMID- 19757021
OWN - NLM
STAT- MEDLINE
DCOM- 20100824
LR  - 20220310
IS  - 1573-3289 (Electronic)
IS  - 0894-587X (Linking)
VI  - 37
IP  - 3
DP  - 2010 May
TI  - Methodological challenges of characterizing usual care psychotherapeutic
      practice.
PG  - 208-20
LID - 10.1007/s10488-009-0237-8 [doi]
AB  - There is minimal existing research providing detailed, reliable data
      characterizing usual community-based psychotherapy practice, and, thus, limited
      established methods for such research. This article identifies methodological
      challenges of usual care descriptive research, including, (a) general design
      considerations, (b) measurement, (c) data analytic, and (d) ethical challenges.
      Case examples drawn from studies reported in this special issue are used to
      illustrate the implications, strengths, and weaknesses of different
      methodological decisions. Central themes include achieving an acceptable balance 
      of scientific rigor, feasibility, and generalizable practice relevance, as well
      as working collaboratively with practice partners to select and implement study
      methods.
FAU - Garland, Ann F
AU  - Garland AF
AD  - Child and Adolescent Services Research Center at Rady Children's Hospital, San
      Diego, CA 92123, USA. agarland@ucsd.edu
FAU - Hurlburt, Michael S
AU  - Hurlburt MS
FAU - Brookman-Frazee, Lauren
AU  - Brookman-Frazee L
FAU - Taylor, Robin M
AU  - Taylor RM
FAU - Accurso, Erin C
AU  - Accurso EC
LA  - eng
GR  - K23 MH077584/MH/NIMH NIH HHS/United States
GR  - K23MH077584/MH/NIMH NIH HHS/United States
GR  - R01MH66070/MH/NIMH NIH HHS/United States
GR  - K01MH064079/MH/NIMH NIH HHS/United States
GR  - K23 MH077584-03/MH/NIMH NIH HHS/United States
GR  - P30MH074678/MH/NIMH NIH HHS/United States
GR  - P30 MH074678/MH/NIMH NIH HHS/United States
GR  - R01 MH066070/MH/NIMH NIH HHS/United States
GR  - K01 MH064079/MH/NIMH NIH HHS/United States
GR  - F31 MH083399-02/MH/NIMH NIH HHS/United States
GR  - F31MH083399/MH/NIMH NIH HHS/United States
GR  - F31 MH083399/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20090912
PL  - United States
TA  - Adm Policy Ment Health
JT  - Administration and policy in mental health
JID - 8914574
SB  - IM
MH  - Community Mental Health Services/*organization & administration
MH  - Health Services Research/*methods
MH  - Humans
MH  - *Psychotherapy
MH  - Quality Indicators, Health Care
MH  - Reproducibility of Results
MH  - Research Design
PMC - PMC2877339
MID - NIHMS181478
EDAT- 2009/09/17 06:00
MHDA- 2010/08/25 06:00
CRDT- 2009/09/17 06:00
PHST- 2009/04/08 00:00 [received]
PHST- 2009/08/10 00:00 [accepted]
PHST- 2009/09/17 06:00 [entrez]
PHST- 2009/09/17 06:00 [pubmed]
PHST- 2010/08/25 06:00 [medline]
AID - 10.1007/s10488-009-0237-8 [doi]
PST - ppublish
SO  - Adm Policy Ment Health. 2010 May;37(3):208-20. doi: 10.1007/s10488-009-0237-8.
      Epub 2009 Sep 12.


PMID- 19754667
OWN - NLM
STAT- MEDLINE
DCOM- 20100810
LR  - 20211020
IS  - 1582-4934 (Electronic)
IS  - 1582-1838 (Linking)
VI  - 14
IP  - 3
DP  - 2010 Mar
TI  - Monocyte transplantation for neural and cardiovascular ischemia repair.
PG  - 553-63
LID - 10.1111/j.1582-4934.2009.00903.x [doi]
AB  - Neovascularization is an integral process of inflammatory reactions and
      subsequent repair cascades in tissue injury. Monocytes/macrophages play a key
      role in the inflammatory process including angiogenesis as well as the defence
      mechanisms by exerting microbicidal and immunomodulatory activity. Current
      studies have demonstrated that recruited monocytes/macrophages aid in regulating 
      angiogenesis in ischemic tissue, tumours and chronic inflammation. In terms of
      neovascularization followed by tissue regeneration, monocytes/macrophages should 
      be highly attractive for cell-based therapy compared to any other stem cells due 
      to their considerable advantages: non-oncogenic, non-teratogenic, multiple
      secretary functions including pro-angiogenic and growth factors, straightforward 
      cell harvesting procedure and non-existent ethical controversy. In addition to
      adult origins such as bone marrow or peripheral blood, umbilical cord blood (UCB)
      can be a potential source for autologous or allogeneic monocytes/macrophages.
      Especially, UCB monocytes should be considered as the first candidate owing to
      their feasibility, low immune rejection and multiple characteristic advantages
      such as their anti-inflammatory properties by virtue of their unique immune and
      inflammatory immaturity, and their pro-angiogenic ability. In this review, we
      present general characteristics and potential of monocytes/macrophages for
      cell-based therapy, especially focusing on neovascularization and UCB-derived
      monocytes.
FAU - Sanberg, Paul R
AU  - Sanberg PR
AD  - Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and
      Brain Repair, University of South Florida College of Medicine, Tampa, FL 33612,
      USA. psanberg@health.usf.edu
FAU - Park, Dong-Hyuk
AU  - Park DH
FAU - Kuzmin-Nichols, Nicole
AU  - Kuzmin-Nichols N
FAU - Cruz, Eduardo
AU  - Cruz E
FAU - Hossne, Nelson Americo Jr
AU  - Hossne NA Jr
FAU - Buffolo, Enio
AU  - Buffolo E
FAU - Willing, Alison E
AU  - Willing AE
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20090914
PL  - England
TA  - J Cell Mol Med
JT  - Journal of cellular and molecular medicine
JID - 101083777
RN  - 0 (Inflammation Mediators)
SB  - IM
MH  - Animals
MH  - Cardiovascular System/physiopathology
MH  - Fetal Blood/cytology
MH  - Humans
MH  - Inflammation Mediators/metabolism
MH  - Ischemia/*metabolism
MH  - Models, Biological
MH  - Monocytes/cytology/*metabolism/*transplantation
MH  - Neovascularization, Physiologic
MH  - Nervous System/blood supply/*metabolism
RF  - 109
PMC - PMC3823455
EDAT- 2009/09/17 06:00
MHDA- 2010/08/11 06:00
CRDT- 2009/09/17 06:00
PHST- 2009/09/17 06:00 [entrez]
PHST- 2009/09/17 06:00 [pubmed]
PHST- 2010/08/11 06:00 [medline]
AID - JCMM903 [pii]
AID - 10.1111/j.1582-4934.2009.00903.x [doi]
PST - ppublish
SO  - J Cell Mol Med. 2010 Mar;14(3):553-63. doi: 10.1111/j.1582-4934.2009.00903.x.
      Epub 2009 Sep 14.


PMID- 19752578
OWN - NLM
STAT- MEDLINE
DCOM- 20100422
LR  - 20131121
IS  - 1661-7819 (Electronic)
IS  - 1661-7800 (Linking)
VI  - 97
IP  - 2
DP  - 2010
TI  - Cardiac output measurement in ventilated lambs with a significant left-to-right
      shunt using the modified carbon dioxide fick method.
PG  - 124-31
LID - 10.1159/000237223 [doi]
AB  - BACKGROUND: It remains a great challenge to measure systemic blood flow in
      critically ill newborns. In a former study we validated the modified carbon
      dioxide Fick (mCO(2)F) method for measurement of cardiac output in a newborn lamb
      model. In this new study we studied the influence of a left-to-right shunt on the
      accuracy of the mCO(2)F method. OBJECTIVE: To analyze the influence of a
      left-to-right shunt on the agreement between cardiac output measurement with the 
      mCO(2)F method and ultrasonic transit time pulmonary blood flow in a lamb model. 
      METHODS: The study was approved by the Ethical Committee on Animal Research of
      the Radboud University Nijmegen and performed in 8 random-bred lambs. A Gore-Tex 
      shunt was placed between the left pulmonary artery and the descending aorta. This
      aortopulmonary shunt was intermittently opened and closed, while cardiac output
      was manipulated by creating hemorrhagic hypotension. Cardiac output measurement
      with the mCO(2)F method (Q(mCO2F)) was compared with pulmonary blood flow
      obtained by a transit time ultrasonic flow probe positioned around the common
      pulmonary artery (Q(APC)). RESULTS: Bias, defined as Q(mCO2F) - Q(APC), was
      calculated for each measurement. With an open shunt there was a significant
      left-to-right shunt (mean Qp/Qs ratio 2.26; range 1.56-3.69). Mean bias (SD) was 
      -12.3 (50.4) ml x kg(-1) x min(-1) and -12.3 (42.7) ml x kg(-1) x min(-1) for
      measurements with a closed and open shunt, respectively (no statistical
      significant difference). CONCLUSIONS: Cardiac output measurement with the mCO(2)F
      method is reliable and easily applicable in ventilated newborn lambs, also in the
      presence of a significant left-to-right shunt.
CI  - Copyright 2009 S. Karger AG, Basel.
FAU - de Boode, Willem P
AU  - de Boode WP
AD  - Department of Neonatology, Radboud University Nijmegen Medical Centre, Nijmegen, 
      The Netherlands. W.deBoode@cukz.umcn.nl
FAU - Hopman, Jeroen C W
AU  - Hopman JC
FAU - Wijnen, Marc H W A
AU  - Wijnen MH
FAU - Tanke, Ronald B
AU  - Tanke RB
FAU - van der Hoeven, Hans G
AU  - van der Hoeven HG
FAU - Liem, K Djien
AU  - Liem KD
LA  - eng
PT  - Journal Article
DEP - 20090911
PL  - Switzerland
TA  - Neonatology
JT  - Neonatology
JID - 101286577
RN  - 142M471B3J (Carbon Dioxide)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Aorta/physiology
MH  - Blood Pressure/physiology
MH  - Carbon Dioxide/*blood
MH  - Cardiac Output/*physiology
MH  - Models, Animal
MH  - *Models, Cardiovascular
MH  - Monitoring, Physiologic/*methods/standards
MH  - Pulmonary Circulation/physiology
MH  - Reproducibility of Results
MH  - *Respiration, Artificial
MH  - Sheep
EDAT- 2009/09/16 06:00
MHDA- 2010/04/23 06:00
CRDT- 2009/09/16 06:00
PHST- 2008/10/27 00:00 [received]
PHST- 2009/02/09 00:00 [accepted]
PHST- 2009/09/16 06:00 [entrez]
PHST- 2009/09/16 06:00 [pubmed]
PHST- 2010/04/23 06:00 [medline]
AID - 000237223 [pii]
AID - 10.1159/000237223 [doi]
PST - ppublish
SO  - Neonatology. 2010;97(2):124-31. doi: 10.1159/000237223. Epub 2009 Sep 11.


PMID- 19735732
OWN - NLM
STAT- MEDLINE
DCOM- 20100408
LR  - 20150831
IS  - 1096-1186 (Electronic)
IS  - 1043-6618 (Linking)
VI  - 61
IP  - 1
DP  - 2010 Jan
TI  - Theobroma cacao L., the Food of the Gods: a scientific approach beyond myths and 
      claims.
PG  - 5-13
LID - 10.1016/j.phrs.2009.08.008 [doi]
AB  - Cocoa beans are rich source of polyphenols, contributing about 10% of the dry
      weight of the whole bean and its derivative chocolate, particularly dark
      chocolate, is considered one of the major contributors of antioxidants to the
      American diet after fruits and vegetables. At present the wide variation in cocoa
      processing and in the content and profile of polyphenols make it difficult to
      determine to what extent the findings about positive effects expressed in
      different studies, translate into tangible clinical benefits. Moreover, before
      claiming any healthy properties to a plant, natural product or food item on human
      subject, a basic research project approved by scientific and ethical commissions 
      has to be performed. Until now the definition, composition, manufacturing
      specifications, packaging and labelling of cocoa and chocolate products in
      Europe, are regulated by "Directive 2000/36/EC of the European parliament and of 
      the council". The definitions take changes in consumer tastes, chocolate
      composition and labelling into account, but do not consider the real potential of
      healthy, beneficial and nutraceutical effects. In fact, they fail to establish an
      official analytical methodology for the quantification of phenolic compounds in
      cocoa and chocolate. Moreover quantification of these compounds is not used in
      product classification. This article reviews many qualitative differences of
      cocoa and chocolate, in particular dark chocolate, aiming to establish the
      different implications for public health through the use of the analyzed
      concentration of polyphenols in cocoa products.
CI  - Copyright 2009 Elsevier Ltd. All rights reserved.
FAU - Rusconi, M
AU  - Rusconi M
AD  - Alpine Foundation for Life Sciences (AFLS), 6718 Olivone, Switzerland.
      manuelrusconi@bluewin.ch
FAU - Conti, A
AU  - Conti A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20090906
PL  - Netherlands
TA  - Pharmacol Res
JT  - Pharmacological research
JID - 8907422
RN  - 0 (Flavonoids)
RN  - 0 (Phenols)
RN  - 0 (Plant Extracts)
RN  - 0 (Polyphenols)
SB  - IM
MH  - Animals
MH  - *Cacao/chemistry
MH  - *Candy/adverse effects/analysis/standards
MH  - Consumer Product Safety
MH  - Drug Labeling
MH  - European Union
MH  - Evidence-Based Medicine
MH  - Flavonoids/adverse effects/isolation &
      purification/pharmacokinetics/*pharmacology
MH  - Food Labeling
MH  - *Functional Food/adverse effects/analysis/standards
MH  - Humans
MH  - *Mythology
MH  - Nutrition Policy
MH  - Phenols/adverse effects/isolation & purification/pharmacokinetics/*pharmacology
MH  - Plant Extracts/adverse effects/isolation &
      purification/pharmacokinetics/*pharmacology/standards
MH  - Plants, Medicinal
MH  - Polyphenols
MH  - Quality Control
RF  - 115
EDAT- 2009/09/09 06:00
MHDA- 2010/04/09 06:00
CRDT- 2009/09/09 06:00
PHST- 2009/06/02 00:00 [received]
PHST- 2009/08/30 00:00 [revised]
PHST- 2009/08/31 00:00 [accepted]
PHST- 2009/09/09 06:00 [entrez]
PHST- 2009/09/09 06:00 [pubmed]
PHST- 2010/04/09 06:00 [medline]
AID - S1043-6618(09)00239-4 [pii]
AID - 10.1016/j.phrs.2009.08.008 [doi]
PST - ppublish
SO  - Pharmacol Res. 2010 Jan;61(1):5-13. doi: 10.1016/j.phrs.2009.08.008. Epub 2009
      Sep 6.


PMID- 19734795
OWN - NLM
STAT- MEDLINE
DCOM- 20101007
LR  - 20151119
IS  - 1473-5695 (Electronic)
IS  - 0969-9546 (Linking)
VI  - 17
IP  - 4
DP  - 2010 Aug
TI  - Patients' and relatives' view on witnessed resuscitation in the emergency
      department: a prospective study.
PG  - 203-7
LID - 10.1097/MEJ.0b013e328331477e [doi]
AB  - BACKGROUND: The appropriateness of family witnessing resuscitation (FWR) is an
      ethical dilemma with most emergency care providers being opponents. We
      hypothesized that patients and their families prefer to witness resuscitation of 
      their loved ones. METHODS: One hundred and fifty patients treated for potential
      life-threatening conditions in our emergency department were presented with a
      survey on FWR in the reconvalescence phase. They were asked to give their opinion
      supposing their situation had worsened, requiring a resuscitation effort. Their
      closest relatives were asked to complete a related questionnaire. RESULTS: Mean
      age was 67 years (patient group) and 55 years (relatives group). Fifty-eight
      percent of the patients were males with only 33% males in the relatives group.
      Seventy-two percent of the patients preferred the presence of a relative during
      resuscitation, although 35% estimate that this could be quite a traumatic
      experience. Forty-one percent had a history of serious medical problems. In the
      relatives group, 75% expressed their wish to stay with their loved ones and 49%
      did not fear that this would be too traumatic. There was a good match in patient 
      and family attitude towards FWR (P<0.001). Relatives of a patient with a serious 
      medical history were significantly more in favour of FWR (P<0.01). CONCLUSION:
      Our study showed that patients and relatives preferred family presence in
      emergency department during resuscitation, even when the fear of traumatic
      effects is considered. It will be a great challenge training emergency care
      providers for this situation. Staff shortages might compromise the essential
      support of family members in such situations.
FAU - Mortelmans, Luc J M
AU  - Mortelmans LJ
AD  - . Department of Emergency Medicine, KLINA Regional Hospital, Augustijnslei 100,
      B2930 Brasschaat, Belgium. luc.mortelmans@klina.be
FAU - Van Broeckhoven, Veronique
AU  - Van Broeckhoven V
FAU - Van Boxstael, Sam
AU  - Van Boxstael S
FAU - De Cauwer, Harald G
AU  - De Cauwer HG
FAU - Verfaillie, Luc
AU  - Verfaillie L
FAU - Van Hellemond, Peter L A
AU  - Van Hellemond PL
FAU - Van Colen, Sieglinde
AU  - Van Colen S
FAU - Cas, Wendy M F
AU  - Cas WM
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur J Emerg Med
JT  - European journal of emergency medicine : official journal of the European Society
      for Emergency Medicine
JID - 9442482
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Catastrophic Illness/psychology
MH  - Emergency Service, Hospital/standards
MH  - *Family Relations
MH  - Female
MH  - Humans
MH  - Male
MH  - Medical Staff, Hospital/psychology
MH  - Middle Aged
MH  - Prospective Studies
MH  - Resuscitation Orders/ethics/*psychology
MH  - Surveys and Questionnaires
MH  - Survivors/*psychology
MH  - Young Adult
EDAT- 2009/09/08 06:00
MHDA- 2010/10/12 06:00
CRDT- 2009/09/08 06:00
PHST- 2009/09/08 06:00 [entrez]
PHST- 2009/09/08 06:00 [pubmed]
PHST- 2010/10/12 06:00 [medline]
AID - 10.1097/MEJ.0b013e328331477e [doi]
PST - ppublish
SO  - Eur J Emerg Med. 2010 Aug;17(4):203-7. doi: 10.1097/MEJ.0b013e328331477e.


PMID- 19732996
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20161125
IS  - 1532-2793 (Electronic)
IS  - 0260-6917 (Linking)
VI  - 30
IP  - 2
DP  - 2010 Feb
TI  - Nursing students as research participants: a framework for ethical practice.
PG  - 192-6
LID - 10.1016/j.nedt.2009.07.013 [doi]
AB  - AIM: The aim is to discuss a new framework that can aid ethical decision making
      in educational nursing research. BACKGROUND: Nurse researchers have a significant
      amount of guidance to inform their ethical decision making in relation to
      research. However, research governance and professional guidance only go so far
      in promoting ethical research practice. Nurse researchers who work in higher
      education institutes face particular ethical challenges when nursing students are
      used as research participants. METHOD: We explore the complexities of educational
      research and introduce a framework that can help nurse researchers to make
      ethically sound research decisions. We draw inspiration from Wendler and Grady
      (2008) [Wendler, D., Grady, C., 2008. What should research participants
      understand to understand they are participants in research? Bioethics, 22(4),
      203-208] who explored the issue of informed consent in bioethical research. They 
      proposed three key issues that researchers need to consider: research
      contribution; research relationship and research impact. Inspired by their work, 
      we have developed the Framework for Ethical Research Practice for use in a
      nursing context. Using examples from our research, we show how the framework can 
      be a useful tool for nurse researchers to assist them in making ethically sound
      research decisions. CONCLUSION: This new framework should appeal to researchers
      seeking innovative ways of enhancing the ethical realm of their practice.
CI  - Copyright 2009 Elsevier Ltd. All rights reserved.
FAU - Bradbury-Jones, Caroline
AU  - Bradbury-Jones C
AD  - School of Healthcare Sciences, Bangor University, Archimedes Centre, Wrexham
      Technology Park, Wrexham LL13 7YP, UK. c.bradburyjones@dundee.ac.uk
FAU - Alcock, John
AU  - Alcock J
LA  - eng
PT  - Journal Article
DEP - 20090903
PL  - Scotland
TA  - Nurse Educ Today
JT  - Nurse education today
JID - 8511379
MH  - *Community Participation
MH  - *Decision Making
MH  - Ethics, Nursing
MH  - *Ethics, Research
MH  - Humans
MH  - Informed Consent
MH  - *Nursing Education Research
MH  - *Patient Selection
MH  - *Students, Nursing
EDAT- 2009/09/08 06:00
MHDA- 2011/01/07 06:00
CRDT- 2009/09/08 06:00
PHST- 2009/04/24 00:00 [received]
PHST- 2009/07/24 00:00 [accepted]
PHST- 2009/09/08 06:00 [entrez]
PHST- 2009/09/08 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
AID - S0260-6917(09)00145-2 [pii]
AID - 10.1016/j.nedt.2009.07.013 [doi]
PST - ppublish
SO  - Nurse Educ Today. 2010 Feb;30(2):192-6. doi: 10.1016/j.nedt.2009.07.013. Epub
      2009 Sep 3.


PMID- 19732177
OWN - NLM
STAT- MEDLINE
DCOM- 20100813
LR  - 20181201
IS  - 1468-1293 (Electronic)
IS  - 1464-2662 (Linking)
VI  - 11
IP  - 1
DP  - 2010 Jan
TI  - Fertility needs and funding in couples with blood-borne viral infection.
PG  - 90-3
LID - 10.1111/j.1468-1293.2009.00749.x [doi]
AB  - BACKGROUND: Couples infected with HIV, hepatitis B virus (HBV) and hepatitis C
      virus (HCV) are increasingly seeking assisted conception. These couples avoid
      unprotected intercourse and use condoms at all times in order to minimize the
      risk of infecting their partner. As this practice inhibits pregnancy, assisted
      procreation is generally required for safe conception. For many couples, access
      to such services is restricted on ethical, geographical and financial grounds.
      OBJECTIVE: The aim of the study was to assess the fertility needs, geographical
      origin and state funding of patients with blood-borne viral infection. METHODS: A
      retrospective review of the medical records of couples referred for fertility
      treatment between January 1999 and December 2006, where one or both partners were
      infected with HIV, HBV and/or HCV, was carried out. RESULTS: Of the 205 couples
      included in the study, 44% lived in London, 51% came from elsewhere in the United
      Kingdom and 5% travelled from outside the United Kingdom to seek treatment.
      Genitourinary medicine clinics were the main source of referral. 85.8% of couples
      had HIV infection, 15.1% were infected with HBV and 13.6% had HCV infection.
      Fertility screening identified a high incidence of male factor infertility
      (33.3%) in HIV-infected men and tubal disease (40.8%) in HIV-infected women. Only
      23.6% of HIV-infected couples, 20% of HBV-infected couples and 12.5% of
      HCV-infected couples obtained state funding for assisted conception. CONCLUSION: 
      Fertility screening identified a high incidence of male and tubal factor
      subfertility among couples living with HIV, HBV and HCV. Limited access to
      specialist clinics equipped to cater for these couples and restricted funding may
      impact negatively on couples obtaining risk-reducing assisted reproduction
      treatment. This may have long-term public health implications as individuals
      attempt to conceive through unprotected intercourse.
FAU - Kalu, E
AU  - Kalu E
AD  - Assisted Conception Unit, Chelsea and Westminster Hospital, London, UK.
      ekalu@doctors.org.uk
FAU - Wood, R
AU  - Wood R
FAU - Vourliotis, M
AU  - Vourliotis M
FAU - Gilling-Smith, C
AU  - Gilling-Smith C
LA  - eng
PT  - Journal Article
DEP - 20090901
PL  - England
TA  - HIV Med
JT  - HIV medicine
JID - 100897392
SB  - IM
MH  - Condoms/statistics & numerical data
MH  - Confidentiality
MH  - Disease Transmission, Infectious/prevention & control
MH  - Female
MH  - HIV Infections/*complications
MH  - Health Services Accessibility/*statistics & numerical data
MH  - Hepatitis, Viral, Human/complications
MH  - Humans
MH  - Infertility/complications/epidemiology/*therapy
MH  - Male
MH  - Patient Acceptance of Health Care/statistics & numerical data
MH  - Referral and Consultation/statistics & numerical data
MH  - Reproductive Techniques, Assisted/*economics
MH  - Retrospective Studies
MH  - United Kingdom
EDAT- 2009/09/08 06:00
MHDA- 2010/08/14 06:00
CRDT- 2009/09/08 06:00
PHST- 2009/09/08 06:00 [entrez]
PHST- 2009/09/08 06:00 [pubmed]
PHST- 2010/08/14 06:00 [medline]
AID - HIV749 [pii]
AID - 10.1111/j.1468-1293.2009.00749.x [doi]
PST - ppublish
SO  - HIV Med. 2010 Jan;11(1):90-3. doi: 10.1111/j.1468-1293.2009.00749.x. Epub 2009
      Sep 1.


PMID- 19730167
OWN - NLM
STAT- MEDLINE
DCOM- 20100719
LR  - 20100422
IS  - 1540-0514 (Electronic)
IS  - 1073-2322 (Linking)
VI  - 33
IP  - 4
DP  - 2010 Apr
TI  - Strategies of experiment standardization and response optimization in a rat model
      of hemorrhagic shock and chronic hypertension.
PG  - 442-9
LID - 10.1097/SHK.0b013e3181b926a2 [doi]
AB  - Exploratory pilot studies are crucial to best practice in research but are
      frequently conducted without a systematic method for maximizing the amount and
      quality of information obtained. We describe the use of response surface
      regression models and simultaneous optimization methods to develop a rat model of
      hemorrhagic shock in the context of chronic hypertension, a clinically relevant
      comorbidity. Response surface regression model was applied to determine optimal
      levels of two inputs--dietary NaCl concentration (0.49%, 4%, and 8%) and time on 
      the diet (4, 6, 8 weeks)--to achieve clinically realistic and stable target
      measures of systolic blood pressure while simultaneously maximizing critical
      oxygen delivery (a measure of vulnerability to hemorrhagic shock) and body mass
      M. Simultaneous optimization of the three response variables was performed though
      a dimensionality reduction strategy involving calculation of a single aggregate
      measure, the "desirability" function. Optimal conditions for inducing systolic
      blood pressure of 208 mmHg, critical oxygen delivery of 4.03 mL/min, and M of 290
      g were determined to be 4% [NaCl] for 5 weeks. Rats on the 8% diet did not
      survive past 7 weeks. Response surface regression model and simultaneous
      optimization method techniques are commonly used in process engineering but have 
      found little application to date in animal pilot studies. These methods will
      ensure both the scientific and ethical integrity of experimental trials involving
      animals and provide powerful tools for the development of novel models of
      clinically interacting comorbidities with shock.
FAU - Reynolds, Penny S
AU  - Reynolds PS
AD  - Department of Emergency Medicine, Virginia Commonwealth University Medical
      Center, Richmond, Virginia 23298, USA. psreynolds@vcu.edu
FAU - Tamariz, Francisco J
AU  - Tamariz FJ
FAU - Barbee, Robert Wayne
AU  - Barbee RW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Shock
JT  - Shock (Augusta, Ga.)
JID - 9421564
RN  - 0 (Sodium Chloride, Dietary)
SB  - IM
MH  - Animals
MH  - *Disease Models, Animal
MH  - *Hypertension
MH  - Male
MH  - Pilot Projects
MH  - Rats
MH  - Rats, Inbred Dahl
MH  - Reference Standards
MH  - Regression Analysis
MH  - *Shock, Hemorrhagic
MH  - Sodium Chloride, Dietary/administration & dosage
EDAT- 2009/09/05 06:00
MHDA- 2010/07/20 06:00
CRDT- 2009/09/05 06:00
PHST- 2009/09/05 06:00 [entrez]
PHST- 2009/09/05 06:00 [pubmed]
PHST- 2010/07/20 06:00 [medline]
AID - 10.1097/SHK.0b013e3181b926a2 [doi]
PST - ppublish
SO  - Shock. 2010 Apr;33(4):442-9. doi: 10.1097/SHK.0b013e3181b926a2.


PMID- 19729373
OWN - NLM
STAT- MEDLINE
DCOM- 20100222
LR  - 20091216
IS  - 1460-2369 (Electronic)
IS  - 1355-4786 (Linking)
VI  - 16
IP  - 1
DP  - 2010 Jan-Feb
TI  - Sex and reproduction: an evolving relationship.
PG  - 96-107
LID - 10.1093/humupd/dmp028 [doi]
AB  - BACKGROUND: Although sexual activity has, until very recently, been essential to 
      reproduction, this did not preclude the non-reproductive importance of sexual
      relationships and non-conceptive copulations. Technological advances, however,
      now allow for both sex without reproduction and reproduction without sex. This
      review summarizes social and ethical commentaries on the new relationship between
      sex and reproduction. METHODS: For each main area discussed, a systematic search 
      was made using (depending on the subject) PubMed, Medline, ScienceDirect, classic
      books, Google and/or religious websites. The search focused on publications
      between 1975 and 2009, although some materials from the first part of the 20th
      century were also utilized. RESULTS: The classic picture of sex for reproduction 
      and bonding between mating partners is increasingly being replaced by
      reproduction separate from sexual activity. Although not every advance in
      assisted reproduction produced, per se, a further separation from sexual
      intercourse, these two fundamental human activities are today increasingly
      carried out independently, as reproduction is possible, not only without sex, but
      even through the intervention of more than two partners. The possibility of
      reproduction with only one or even no gametes, although highly controversial and 
      not yet feasible, is nonetheless being investigated. CONCLUSIONS: Technological
      advances in the field of reproductive biology have enabled couples considered
      infertile to conceive and have healthy babies, causing a revolution in culture
      and customs. Today the independence of sex and reproduction is established and in
      the future human reproduction may move even further away from the sexual act, an 
      option definitely unacceptable to some ethicists.
FAU - Benagiano, Giuseppe
AU  - Benagiano G
AD  - Department of Obstetrics and Gynaecology, Sapienza University, Rome, Italy.
      giuseppe.benagiano@uniroma1.it
FAU - Carrara, Sabina
AU  - Carrara S
FAU - Filippi, Valentina
AU  - Filippi V
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Hum Reprod Update
JT  - Human reproduction update
JID - 9507614
SB  - IM
MH  - Coitus/psychology
MH  - Contraception Behavior/psychology
MH  - Female
MH  - Humans
MH  - Male
MH  - *Reproduction
MH  - Reproductive Techniques, Assisted
MH  - *Sexual Behavior
MH  - Sexuality/psychology
RF  - 123
EDAT- 2009/09/05 06:00
MHDA- 2010/02/23 06:00
CRDT- 2009/09/05 06:00
PHST- 2009/09/05 06:00 [entrez]
PHST- 2009/09/05 06:00 [pubmed]
PHST- 2010/02/23 06:00 [medline]
AID - dmp028 [pii]
AID - 10.1093/humupd/dmp028 [doi]
PST - ppublish
SO  - Hum Reprod Update. 2010 Jan-Feb;16(1):96-107. doi: 10.1093/humupd/dmp028.


PMID- 19728164
OWN - NLM
STAT- MEDLINE
DCOM- 20100923
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 16
IP  - 2
DP  - 2010 Jun
TI  - The social construction of copyright ethics and values.
PG  - 263-93
LID - 10.1007/s11948-009-9162-1 [doi]
AB  - This study is based on analysis of copyright policies and 26 interviews with
      science and engineering faculty at three research universities on the topic of
      copyright beliefs, values, and practices, with emphasis on copyright of
      instructional materials, courseware, tools, and texts. Given that research
      universities now emphasize increasing external revenue flows through marketing of
      intellectual property, we expected copyright to follow the path of patents and
      lead to institutional emphasis of policies and practices that enhanced
      universities' intellectual property portfolios, accompanied by an increase in
      copyrighting by professors. Although this pattern occurred with regard to
      institutions, professors offered a more varied pattern, with some fully
      participating in commercialization of copyright and embracing entrepreneurial
      values, while others resisted or subverted commercial activity in favor of
      traditional science and engineering values.
FAU - Slaughter, Sheila
AU  - Slaughter S
AD  - Institute of Higher Education, University of Georgia, Athens, GA 30605, USA.
      slaughtr@uga.edu
FAU - Rhoades, Gary
AU  - Rhoades G
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20090901
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Attitude
MH  - Biological Science Disciplines/education/*ethics/organization & administration
MH  - Chemical Engineering/education/*ethics/organization & administration
MH  - Chemistry/education/*ethics/organization & administration
MH  - Commodification
MH  - Copyright/*ethics
MH  - Entrepreneurship/ethics
MH  - Ethics, Institutional
MH  - Ethics, Research
MH  - *Faculty/organization & administration
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Male
MH  - Organizational Policy
MH  - Ownership/ethics
MH  - Patents as Topic/ethics
MH  - Professional Autonomy
MH  - Social Values
MH  - Surveys and Questionnaires
MH  - Teaching Materials
MH  - Textbooks as Topic
MH  - Universities/*ethics/organization & administration
EDAT- 2009/09/04 06:00
MHDA- 2010/09/24 06:00
CRDT- 2009/09/04 06:00
PHST- 2009/02/12 00:00 [received]
PHST- 2009/08/14 00:00 [accepted]
PHST- 2009/09/04 06:00 [entrez]
PHST- 2009/09/04 06:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
AID - 10.1007/s11948-009-9162-1 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2010 Jun;16(2):263-93. doi: 10.1007/s11948-009-9162-1. Epub 2009 
      Sep 1.


PMID- 19728163
OWN - NLM
STAT- MEDLINE
DCOM- 20110210
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 16
IP  - 3
DP  - 2010 Sep
TI  - Teaching virtue: pedagogical implications of moral psychology.
PG  - 611-28
LID - 10.1007/s11948-009-9164-z [doi]
AB  - Moral exemplar studies of computer and engineering professionals have led ethics 
      teachers to expand their pedagogical aims beyond moral reasoning to include the
      skills of moral expertise. This paper frames this expanded moral curriculum in a 
      psychologically informed virtue ethics. Moral psychology provides a description
      of character distributed across personality traits, integration of moral value
      into the self system, and moral skill sets. All of these elements play out on the
      stage of a social surround called a moral ecology. Expanding the practical and
      professional curriculum to cover the skills and competencies of moral expertise
      converts the classroom into a laboratory where students practice moral expertise 
      under the guidance of their teachers. The good news is that this expanded
      pedagogical approach can be realized without revolutionizing existing methods of 
      teaching ethics. What is required, instead, is a redeployment of existing
      pedagogical tools such as cases, professional codes, decision-making frameworks, 
      and ethics tests. This essay begins with a summary of virtue ethics and informs
      this with recent research in moral psychology. After identifying pedagogical
      means for teaching ethics, it shows how these can be redeployed to meet a
      broader, skills based agenda. Finally, short module profiles offer concrete
      examples of the shape this redeployed pedagogical agenda would take in the
      practical and professional ethics classroom.
FAU - Frey, William J
AU  - Frey WJ
AD  - College of Business Administration, Recinto Universitario de Mayaguez, Mayaguez, 
      Puerto Rico. freyuprm@gmail.com
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20090901
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Engineering/education/ethics
MH  - Ethics, Professional/*education
MH  - Humans
MH  - *Morals
MH  - *Social Values
MH  - Teaching/*ethics/methods
MH  - Virtues
EDAT- 2009/09/04 06:00
MHDA- 2011/02/11 06:00
CRDT- 2009/09/04 06:00
PHST- 2009/05/05 00:00 [received]
PHST- 2009/08/14 00:00 [accepted]
PHST- 2009/09/04 06:00 [entrez]
PHST- 2009/09/04 06:00 [pubmed]
PHST- 2011/02/11 06:00 [medline]
AID - 10.1007/s11948-009-9164-z [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2010 Sep;16(3):611-28. doi: 10.1007/s11948-009-9164-z. Epub 2009 
      Sep 1.


PMID- 19727530
OWN - NLM
STAT- MEDLINE
DCOM- 20101019
LR  - 20220408
IS  - 1433-9285 (Electronic)
IS  - 0933-7954 (Linking)
VI  - 45
IP  - 9
DP  - 2010 Sep
TI  - Incidence of seclusion and restraint in psychiatric hospitals: a literature
      review and survey of international trends.
PG  - 889-97
LID - 10.1007/s00127-009-0132-3 [doi]
AB  - OBJECTIVE: The aim of this study was to identify quantitative data on the use of 
      seclusion and restraint in different countries and on initiatives to reduce these
      interventions. METHODS: Combined literature review on initiatives to reduce
      seclusion and restraint, and epidemiological data on the frequency and means of
      use in the 21st century in different countries. Unpublished study was detected by
      contacting authors of conference presentations. Minimum requirements for the
      inclusion of data were reporting the incidence of coercive measures in complete
      hospital populations for defined periods and related to defined catchment areas. 
      RESULTS: There are initiatives to gather data and to develop new clinical
      practice in several countries. However, data on the use of seclusion and
      restraint are scarcely available so far. Data fulfilling the inclusion criteria
      could be detected from 12 different countries, covering single or multiple
      hospitals in most counties and complete national figures for two countries
      (Norway, Finland). Both mechanical restraint and seclusion are forbidden in some 
      countries for ethical reasons. Available data suggest that there are huge
      differences in the percentage of patients subject to and the duration of coercive
      interventions between countries. CONCLUSIONS: Databases on the use of seclusion
      and restraint should be established using comparable key indicators. Comparisons 
      between countries and different practices can help to overcome prejudice and
      improve clinical practice.
FAU - Steinert, Tilman
AU  - Steinert T
AD  - Centres for Psychiatry Suedwuerttemberg, Ulm University, Weingartshofer Strasse
      2, 88214 Ravensburg-Weissenau, Germany. tilman.steinert@zfp-weissenau.de
FAU - Lepping, Peter
AU  - Lepping P
FAU - Bernhardsgrutter, Renate
AU  - Bernhardsgrutter R
FAU - Conca, Andreas
AU  - Conca A
FAU - Hatling, Trond
AU  - Hatling T
FAU - Janssen, Wim
AU  - Janssen W
FAU - Keski-Valkama, Alice
AU  - Keski-Valkama A
FAU - Mayoral, Fermin
AU  - Mayoral F
FAU - Whittington, Richard
AU  - Whittington R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
DEP - 20090902
PL  - Germany
TA  - Soc Psychiatry Psychiatr Epidemiol
JT  - Social psychiatry and psychiatric epidemiology
JID - 8804358
SB  - IM
MH  - Coercion
MH  - Cross-Cultural Comparison
MH  - Hospitals, Psychiatric/ethics/*statistics & numerical data/trends
MH  - Humans
MH  - Incidence
MH  - Mental Disorders/epidemiology/therapy
MH  - Patient Isolation/ethics/legislation & jurisprudence/*statistics & numerical data
MH  - Prejudice
MH  - Restraint, Physical/ethics/legislation & jurisprudence/*statistics & numerical
      data
EDAT- 2009/09/04 06:00
MHDA- 2010/10/20 06:00
CRDT- 2009/09/04 06:00
PHST- 2008/12/02 00:00 [received]
PHST- 2009/08/18 00:00 [accepted]
PHST- 2009/09/04 06:00 [entrez]
PHST- 2009/09/04 06:00 [pubmed]
PHST- 2010/10/20 06:00 [medline]
AID - 10.1007/s00127-009-0132-3 [doi]
PST - ppublish
SO  - Soc Psychiatry Psychiatr Epidemiol. 2010 Sep;45(9):889-97. doi:
      10.1007/s00127-009-0132-3. Epub 2009 Sep 2.


PMID- 19725073
OWN - NLM
STAT- MEDLINE
DCOM- 20091123
LR  - 20181201
IS  - 1097-4652 (Electronic)
IS  - 0021-9541 (Linking)
VI  - 222
IP  - 1
DP  - 2010 Jan
TI  - Mesenchymal stem cells in regenerative medicine: opportunities and challenges for
      articular cartilage and intervertebral disc tissue engineering.
PG  - 23-32
LID - 10.1002/jcp.21915 [doi]
AB  - Defects of load-bearing connective tissues such as articular cartilage and
      intervertebral disc (IVD) can result from trauma, degenerative, endocrine, or
      age-related disease. Current surgical and pharmacological options for the
      treatment of arthritic rheumatic conditions in the joints and spine are
      ineffective. Cell-based surgical therapies such as autologous chondrocyte
      transplantation (ACT) have been in clinical use for cartilage repair for over a
      decade but this approach has shown mixed results. This review focuses on the
      potential of mesenchymal stem cells (MSCs) as an alternative to cells derived
      from patient tissues in autologous transplantation and tissue engineering. Here
      we discuss the prospects of using MSCs in regenerative medicine and summarize the
      advantages and disadvantages of these cells in articular cartilage and IVD tissue
      engineering. We discuss the conceptual and practical difficulties associated with
      differentiating and pre-conditioning MSCs for subsequent survival in a
      physiologically harsh extracellular matrix, an environment that will be highly
      hypoxic, acidic, and nutrient deprived. Implanted MSCs will be exposed to
      traumatic physical loads and high levels of locally produced inflammatory
      mediators and catabolic cytokines. We also explore the potential of culture
      models of MSCs, fully differentiated cells and co-cultures as "proof of
      principle" ethically acceptable "3Rs" models for engineering articular cartilage 
      and IVD in vitro for the purpose of replacing the use of animals in arthritis
      research.
FAU - Richardson, Stephen M
AU  - Richardson SM
AD  - Tissue Injury and Repair Group, Faculty of Medical and Human Sciences, University
      of Manchester, Manchester, UK.
FAU - Hoyland, Judith A
AU  - Hoyland JA
FAU - Mobasheri, Reza
AU  - Mobasheri R
FAU - Csaki, Constanze
AU  - Csaki C
FAU - Shakibaei, Mehdi
AU  - Shakibaei M
FAU - Mobasheri, Ali
AU  - Mobasheri A
LA  - eng
GR  - BB/G018030/1/Biotechnology and Biological Sciences Research Council/United
      Kingdom
GR  - BBSRC/S/M/2006/13141/Biotechnology and Biological Sciences Research
      Council/United Kingdom
GR  - CVRT VS 0901/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - J Cell Physiol
JT  - Journal of cellular physiology
JID - 0050222
SB  - IM
MH  - Animals
MH  - Cartilage, Articular/cytology/*physiology
MH  - Humans
MH  - Intervertebral Disc/cytology/*physiology
MH  - Mesenchymal Stem Cells/*cytology
MH  - Models, Biological
MH  - *Regenerative Medicine
MH  - Tissue Engineering/*methods
RF  - 150
EDAT- 2009/09/03 06:00
MHDA- 2009/12/16 06:00
CRDT- 2009/09/03 09:00
PHST- 2009/09/03 09:00 [entrez]
PHST- 2009/09/03 06:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
AID - 10.1002/jcp.21915 [doi]
PST - ppublish
SO  - J Cell Physiol. 2010 Jan;222(1):23-32. doi: 10.1002/jcp.21915.


PMID- 19723523
OWN - NLM
STAT- MEDLINE
DCOM- 20100831
LR  - 20100804
IS  - 1090-2449 (Electronic)
IS  - 0014-4894 (Linking)
VI  - 126
IP  - 1
DP  - 2010 Sep
TI  - Novel in vitro and in vivo models to study central nervous system infections due 
      to Acanthamoeba spp.
PG  - 69-72
LID - 10.1016/j.exppara.2009.08.018 [doi]
AB  - Acanthamoeba granulomatous encephalitis is a serious human infection with fatal
      consequences. The most distressing aspect of Acanthamoeba granulomatous
      encephalitis is the limited improvement in mortality. The underlying neurobiology
      is at present not well understood and treatment options are often of limited
      efficacy. There is therefore a real need to obtain more knowledge regarding the
      pathogenesis and pathophysiology of Acanthamoeba granulomatous encephalitis and
      to develop new chemotherapeutic approaches. However, the difficulties in using
      mammalian models to study this infection have hindered our search for therapeutic
      interventions. Recent availability of the blood-brain barrier, in vitro and use
      of locust as an in vivo model will undoubtedly allow us to investigate disease
      pathogenesis, mechanisms of parasite traversal across the blood-brain barrier and
      new drug therapies. It is argued that the models described here can offer several
      advantages in terms of speed, cost, technical convenience, and ethical
      acceptance. Furthermore, they are extremely valuable tools to discriminate
      molecules participating from both sides of the host-parasite interaction and will
      generate potentially useful leads in the identification of new potential drugs,
      as well as testing drug toxicity.
CI  - Copyright 2009 Elsevier Inc. All rights reserved.
FAU - Khan, Naveed Ahmed
AU  - Khan NA
AD  - School of Veterinary Medicine and Science, University of Nottingham, Sutton
      Bonington, LE12 5RD England, UK. naveed.khan@nottingham.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20090831
PL  - United States
TA  - Exp Parasitol
JT  - Experimental parasitology
JID - 0370713
SB  - IM
MH  - Acanthamoeba/*physiology
MH  - Amebiasis/*parasitology
MH  - Animals
MH  - Blood-Brain Barrier/cytology/*parasitology
MH  - Cells, Cultured
MH  - Central Nervous System Protozoal Infections/*parasitology
MH  - *Disease Models, Animal
MH  - Endothelial Cells/parasitology
MH  - Grasshoppers/parasitology
MH  - Humans
EDAT- 2009/09/03 06:00
MHDA- 2010/09/02 06:00
CRDT- 2009/09/03 09:00
PHST- 2009/08/20 00:00 [received]
PHST- 2009/08/27 00:00 [accepted]
PHST- 2009/09/03 09:00 [entrez]
PHST- 2009/09/03 06:00 [pubmed]
PHST- 2010/09/02 06:00 [medline]
AID - S0014-4894(09)00255-0 [pii]
AID - 10.1016/j.exppara.2009.08.018 [doi]
PST - ppublish
SO  - Exp Parasitol. 2010 Sep;126(1):69-72. doi: 10.1016/j.exppara.2009.08.018. Epub
      2009 Aug 31.


PMID- 19722107
OWN - NLM
STAT- MEDLINE
DCOM- 20100923
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 16
IP  - 2
DP  - 2010 Jun
TI  - Engineering good: how engineering metaphors help us to understand the moral life 
      and change society.
PG  - 371-85
LID - 10.1007/s11948-009-9163-0 [doi]
AB  - Engineering can learn from ethics, but ethics can also learn from engineering. In
      this paper, I discuss what engineering metaphors can teach us about practical
      philosophy. Using metaphors such as calculation, performance, and open source, I 
      articulate two opposing views of morality and politics: one that relies on images
      related to engineering as science and one that draws on images of engineering
      practice. I argue that the latter view and its metaphors provide a more adequate 
      way to understand and guide the moral life. Responding to two problems of
      alienation and taking into account developments such as Fab Lab I then further
      explore the implications of this view for engineering and society.
FAU - Coeckelbergh, Mark
AU  - Coeckelbergh M
AD  - Department of Philosophy, University of Twente, P.O. Box 217, 7500 AE, Enschede, 
      The Netherlands. m.coeckelbergh@utwente.nl
LA  - eng
PT  - Journal Article
DEP - 20090901
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Engineering/*ethics
MH  - Ethical Theory
MH  - Humans
MH  - *Morals
MH  - *Philosophy
MH  - Politics
MH  - Problem Solving/ethics
MH  - Science/ethics
MH  - Semantics
MH  - *Social Change
MH  - *Symbolism
MH  - Thinking/ethics
PMC - PMC2866307
EDAT- 2009/09/02 06:00
MHDA- 2010/09/24 06:00
CRDT- 2009/09/02 09:00
PHST- 2009/04/15 00:00 [received]
PHST- 2009/08/14 00:00 [accepted]
PHST- 2009/09/02 09:00 [entrez]
PHST- 2009/09/02 06:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
AID - 10.1007/s11948-009-9163-0 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2010 Jun;16(2):371-85. doi: 10.1007/s11948-009-9163-0. Epub 2009 
      Sep 1.


PMID- 19705126
OWN - NLM
STAT- MEDLINE
DCOM- 20100426
LR  - 20211020
IS  - 1432-1084 (Electronic)
IS  - 0938-7994 (Linking)
VI  - 20
IP  - 2
DP  - 2010 Feb
TI  - Evolution of emphysema in relation to smoking.
PG  - 286-92
LID - 10.1007/s00330-009-1548-6 [doi]
AB  - PURPOSE: We have little knowledge about the evolution of emphysema, and
      relatively little is understood about its evolution in relation to smoking
      habits. This study aims to assess the evolution of emphysema in asymptomatic
      current and former smokers over 2 years and to investigate the association with
      subjects' characteristics. The study was approved by our Ethics Committee and all
      participants provided written informed consent. MATERIALS AND METHODS: We
      measured emphysema by automatic low-dose computed tomography densitometry in 254 
      current and 282 former smokers enrolled in a lung-cancer screening. The measures 
      were repeated after 2 years. The association between subjects' characteristics,
      smoking habits and emphysema were assessed by chi-squared and Wilcoxon tests.
      Univariate and multivariate odds ratios (OR) with 95% confidence intervals (CI)
      were calculated for the risk of emphysema worsening according to subjects'
      characteristics. We assessed the trend of increasing risk of emphysema
      progression by smoking habits using the Mantel-Haenszel chi-squared test.
      RESULTS: The median percentage increase in emphysema over a 2-year period was
      significantly higher in current than in former smokers (OR 1.8; 95% CI 1.3-2.6; p
      < 0.0001). The risk of worsening emphysema (by 30% in 2 years) in current smokers
      increased with smoking duration (p for trend <0.02). CONCLUSION: As emphysema is 
      a known risk factor for lung cancer, its evaluation could be used as a potential 
      factor for identification of a high-risk population. The evaluation of emphysema 
      progression can be added to low-dose CT screening programmes to inform and incite
      participants to stop smoking.
FAU - Bellomi, Massimo
AU  - Bellomi M
AD  - Department of Radiology, European Institute of Oncology, via Ripamonti 435,
      Milan, Italy. massimo.bellomi@ieo.it
FAU - Rampinelli, Cristiano
AU  - Rampinelli C
FAU - Veronesi, Giulia
AU  - Veronesi G
FAU - Harari, Sergio
AU  - Harari S
FAU - Lanfranchi, Federica
AU  - Lanfranchi F
FAU - Raimondi, Sara
AU  - Raimondi S
FAU - Maisonneuve, Patrick
AU  - Maisonneuve P
LA  - eng
PT  - Journal Article
DEP - 20090825
PL  - Germany
TA  - Eur Radiol
JT  - European radiology
JID - 9114774
SB  - IM
CIN - Eur Radiol. 2010 Jul;20(7):1621-2; author reply 1623. PMID: 20179940
MH  - Absorptiometry, Photon/*statistics & numerical data
MH  - Aged
MH  - Aged, 80 and over
MH  - Causality
MH  - Comorbidity
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Italy/epidemiology
MH  - Male
MH  - Middle Aged
MH  - *Proportional Hazards Models
MH  - Pulmonary Emphysema/*diagnostic imaging/*epidemiology
MH  - Risk Assessment
MH  - Risk Factors
MH  - Smoking/*epidemiology
MH  - Tomography, X-Ray Computed/*statistics & numerical data
EDAT- 2009/08/26 09:00
MHDA- 2010/04/27 06:00
CRDT- 2009/08/26 09:00
PHST- 2009/04/09 00:00 [received]
PHST- 2009/07/12 00:00 [accepted]
PHST- 2009/06/04 00:00 [revised]
PHST- 2009/08/26 09:00 [entrez]
PHST- 2009/08/26 09:00 [pubmed]
PHST- 2010/04/27 06:00 [medline]
AID - 10.1007/s00330-009-1548-6 [doi]
PST - ppublish
SO  - Eur Radiol. 2010 Feb;20(2):286-92. doi: 10.1007/s00330-009-1548-6. Epub 2009 Aug 
      25.


PMID- 19704114
OWN - NLM
STAT- MEDLINE
DCOM- 20110228
LR  - 20101008
IS  - 1558-9129 (Electronic)
IS  - 0161-1461 (Linking)
VI  - 41
IP  - 4
DP  - 2010 Oct
TI  - An issue hiding in plain sight: when are speech-language pathologists special
      educators rather than related services providers?
PG  - 531-8
LID - 10.1044/0161-1461(2009/08-0127) [doi]
AB  - PURPOSE: Under the Individuals With Disabilities Education Act (IDEA; as amended,
      2004), speech-language pathology services may be either special education or a
      related service. Given the absence of guidance documents or research on this
      issue, the purposes of this clinical exchange are to (a) present and analyze the 
      IDEA definitions related to speech-language pathologists (SLPs) and their roles, 
      (b) offer a rationale for the importance of and distinction between their roles, 
      (c) propose an initial conceptualization (i.e., flow chart) to distinguish
      between when an SLP should function as a related services provider versus a
      special educator, and (d) suggest actions to develop and disseminate a clearer
      shared understanding of this issue. METHOD: Federal definitions of special
      education and related services as related to SLPs are discussed in terms of
      determining special education eligibility, meeting student needs, ensuring SLPs
      are following their code of ethics and scope of practice, and facilitating
      appropriate personnel utilization and service delivery planning. CONCLUSION:
      Clarifying the distinction between special education and related services should 
      lead to increased likelihood of appropriate services for students with
      disabilities, improved working conditions for SLPs, and enhanced collaboration
      among team members. This clinical exchange is meant to promote dialogue and
      research about this underexamined issue.
FAU - Giangreco, Michael F
AU  - Giangreco MF
AD  - University of Vermont, 208 Colchester Avenue, Mann Hall 301A, Burlington, VT
      05405, USA. Michael.Giangreco@uvm.edu
FAU - Prelock, Patricia A
AU  - Prelock PA
FAU - Turnbull, H Rutherford 3rd
AU  - Turnbull HR 3rd
LA  - eng
PT  - Journal Article
DEP - 20090824
PL  - United States
TA  - Lang Speech Hear Serv Sch
JT  - Language, speech, and hearing services in schools
JID - 0323431
SB  - IM
MH  - Child
MH  - Communication Disorders/diagnosis/*therapy
MH  - Cooperative Behavior
MH  - Delivery of Health Care/legislation & jurisprudence
MH  - Disability Evaluation
MH  - Education, Special/*legislation & jurisprudence
MH  - Eligibility Determination/legislation & jurisprudence
MH  - Humans
MH  - Interdisciplinary Communication
MH  - Job Description
MH  - Language Therapy/*legislation & jurisprudence
MH  - *Professional Role
MH  - Speech Therapy/*legislation & jurisprudence
MH  - Speech-Language Pathology/*legislation & jurisprudence
MH  - United States
EDAT- 2009/08/26 09:00
MHDA- 2011/03/01 06:00
CRDT- 2009/08/26 09:00
PHST- 2009/08/26 09:00 [entrez]
PHST- 2009/08/26 09:00 [pubmed]
PHST- 2011/03/01 06:00 [medline]
AID - 0161-1461_2009_08-0127 [pii]
AID - 10.1044/0161-1461(2009/08-0127) [doi]
PST - ppublish
SO  - Lang Speech Hear Serv Sch. 2010 Oct;41(4):531-8. doi:
      10.1044/0161-1461(2009/08-0127). Epub 2009 Aug 24.


PMID- 19701865
OWN - NLM
STAT- MEDLINE
DCOM- 20100929
LR  - 20100617
IS  - 1476-4954 (Electronic)
IS  - 1476-4954 (Linking)
VI  - 23
IP  - 7
DP  - 2010 Jul
TI  - Ethic, medical and legal reflections about the fetal protection by a pregnant
      woman suffering, in comorbidity, from HIV infection.
PG  - 593-4
LID - 10.1080/14767050903192200 [doi]
AB  - The trend to have children even if one or both parents suffer from chronic
      diseases is influenced by personal, psycho-organic and social factors. The
      Authors face the moral and professional dilemma of honouring a woman's
      intentions, or persuading her to interrupt her pregnancy to prevent damage to her
      health.
FAU - Cannovo, Nunzia
AU  - Cannovo N
AD  - Department of Public Medicine and Social Safety-Legal Medicine Sector, University
      of Naples Federico II, Via Pansini 5, Naples, Italy. drncannovo@libero.it
FAU - Agangi, Annalisa
AU  - Agangi A
FAU - Sansone, Matilde
AU  - Sansone M
FAU - Buccelli, Paola
AU  - Buccelli P
FAU - Martinelli, Pasquale
AU  - Martinelli P
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - J Matern Fetal Neonatal Med
JT  - The journal of maternal-fetal & neonatal medicine : the official journal of the
      European Association of Perinatal Medicine, the Federation of Asia and Oceania
      Perinatal Societies, the International Society of Perinatal Obstetricians
JID - 101136916
SB  - IM
MH  - Abortion, Induced/ethics/legislation & jurisprudence/*psychology
MH  - Adult
MH  - Comorbidity
MH  - Expert Testimony
MH  - Female
MH  - Fetus/physiology
MH  - HIV Infections/epidemiology/psychology/*therapy
MH  - Humans
MH  - Life
MH  - *Maternal-Fetal Relations/psychology
MH  - Morals
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/epidemiology/psychology/*therapy
MH  - Thinking
MH  - Treatment Refusal/*ethics/*legislation & jurisprudence/psychology
EDAT- 2009/08/25 09:00
MHDA- 2010/09/30 06:00
CRDT- 2009/08/25 09:00
PHST- 2009/08/25 09:00 [entrez]
PHST- 2009/08/25 09:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - 914107051 [pii]
AID - 10.1080/14767050903192200 [doi]
PST - ppublish
SO  - J Matern Fetal Neonatal Med. 2010 Jul;23(7):593-4. doi:
      10.1080/14767050903192200.


PMID- 19701782
OWN - NLM
STAT- MEDLINE
DCOM- 20100831
LR  - 20220408
IS  - 1433-7339 (Electronic)
IS  - 0941-4355 (Linking)
VI  - 18
IP  - 7
DP  - 2010 Jul
TI  - Outcome indicators in palliative care--how to assess quality and success. Focus
      group and nominal group technique in Germany.
PG  - 859-68
LID - 10.1007/s00520-009-0721-4 [doi]
AB  - PURPOSE: The call for clinically relevant outcome criteria has been raised, as
      assessment of adequate quality of service providers is essential with increasing 
      momentum in the development of palliative care in most European countries. The
      aim of this study is to investigate important dimensions and indicators for
      assessment and evaluation of palliative care from the perspective of
      multi-disciplinary German experts working over years in the field of palliative
      care. METHODS: A focus group, using the structured consensus method of the
      improved nominal group technique (INGT), with nine experts from different
      disciplines was conducted in Germany. RESULTS: An abundance of topics (16) were
      identified, pointing at the complexity of the issue. Main topics were: quality of
      life, needs assessments of patients and relatives, resource assessment,
      surveillance of decision-making processes, as well as spiritual well-being. The
      following properties were claimed as essential for outcome criteria sensitivity, 
      without additional burden on patients, easy applicability, scientific validity,
      and helpful for communication within the team, ethical discussions as well as for
      quality management. CONCLUSIONS: The study identified topics considered important
      by experts in clinical practise. The discussions exposed the diversity of demands
      on outcome assessment put up by different stakeholder groups. This and the high
      number of relevant items show the complexity for the agreement on a unique set of
      outcome criteria. Further research considering other perspectives is needed.
FAU - Pastrana, Tania
AU  - Pastrana T
AD  - Department of Palliative Medicine, RWTH Aachen University, Aachen, Germany.
      tpastrana@ukaachen.de
FAU - Radbruch, Lukas
AU  - Radbruch L
FAU - Nauck, Friedemann
AU  - Nauck F
FAU - Hover, Gerhard
AU  - Hover G
FAU - Fegg, Martin
AU  - Fegg M
FAU - Pestinger, Martina
AU  - Pestinger M
FAU - Ross, Josef
AU  - Ross J
FAU - Krumm, Norbert
AU  - Krumm N
FAU - Ostgathe, Christoph
AU  - Ostgathe C
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20090823
PL  - Germany
TA  - Support Care Cancer
JT  - Supportive care in cancer : official journal of the Multinational Association of 
      Supportive Care in Cancer
JID - 9302957
SB  - IM
MH  - Consensus
MH  - Focus Groups
MH  - Germany
MH  - Humans
MH  - Needs Assessment/*organization & administration
MH  - Outcome Assessment, Health Care/*methods
MH  - Palliative Care/*organization & administration/psychology
MH  - Quality Indicators, Health Care/*statistics & numerical data
MH  - *Quality of Life
MH  - Spirituality
PMC - PMC3128732
EDAT- 2009/08/25 09:00
MHDA- 2010/09/02 06:00
CRDT- 2009/08/25 09:00
PHST- 2009/03/18 00:00 [received]
PHST- 2009/08/03 00:00 [accepted]
PHST- 2009/08/25 09:00 [entrez]
PHST- 2009/08/25 09:00 [pubmed]
PHST- 2010/09/02 06:00 [medline]
AID - 10.1007/s00520-009-0721-4 [doi]
PST - ppublish
SO  - Support Care Cancer. 2010 Jul;18(7):859-68. doi: 10.1007/s00520-009-0721-4. Epub 
      2009 Aug 23.


PMID- 19699557
OWN - NLM
STAT- MEDLINE
DCOM- 20100315
LR  - 20220310
IS  - 1097-6760 (Electronic)
IS  - 0196-0644 (Linking)
VI  - 55
IP  - 1
DP  - 2010 Jan
TI  - Ethical challenges and considerations of short-term international medical
      initiatives: an excursion to Ghana as a case study.
PG  - 17-22
LID - 10.1016/j.annemergmed.2009.07.014 [doi]
FAU - Jesus, John E
AU  - Jesus JE
AD  - Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston,
      MA 02215, USA. jjesus@bidmc.harvard.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090821
PL  - United States
TA  - Ann Emerg Med
JT  - Annals of emergency medicine
JID - 8002646
SB  - IM
MH  - Beneficence
MH  - Clinical Competence
MH  - Continuity of Patient Care
MH  - Cultural Competency
MH  - Delivery of Health Care/*ethics
MH  - *Developing Countries
MH  - Education, Medical/*ethics
MH  - Emergency Medicine/education/*ethics
MH  - Ghana
MH  - Health Care Rationing
MH  - Humans
MH  - *International Cooperation
MH  - Licensure, Medical
MH  - Organizational Case Studies
MH  - United States
EDAT- 2009/08/25 09:00
MHDA- 2010/03/17 06:00
CRDT- 2009/08/25 09:00
PHST- 2008/09/11 00:00 [received]
PHST- 2009/06/24 00:00 [revised]
PHST- 2009/07/10 00:00 [accepted]
PHST- 2009/08/25 09:00 [entrez]
PHST- 2009/08/25 09:00 [pubmed]
PHST- 2010/03/17 06:00 [medline]
AID - S0196-0644(09)01259-1 [pii]
AID - 10.1016/j.annemergmed.2009.07.014 [doi]
PST - ppublish
SO  - Ann Emerg Med. 2010 Jan;55(1):17-22. doi: 10.1016/j.annemergmed.2009.07.014. Epub
      2009 Aug 21.


PMID- 19697158
OWN - NLM
STAT- MEDLINE
DCOM- 20100701
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 16
IP  - 1
DP  - 2010 Mar
TI  - UNESCO's activities in ethics.
PG  - 7-15
LID - 10.1007/s11948-009-9161-2 [doi]
AB  - UNESCO is an intergovernmental organization with 193 Member States. It is
      concerned with a broad range of issues regarding education, science and culture. 
      It is the only UN organisation with a mandate in science. Since 1993 it is
      addressing ethics of science and technology, with special emphasis on bioethics. 
      One major objective of the ethics programme is the development of international
      normative standards. This is particularly important since many Member States only
      have a limited infrastructure in bioethics, lacking expertise, educational
      programs, bioethics committees and legal frameworks. UNESCO has recently adopted 
      the Universal Declaration on Bioethics and Human Rights. The focus of current
      activities is now on implementation of this Declaration. Three activities are
      discussed that aim at improving and reinforcing the ethics infrastructure in
      relation to science and technology: the Global Ethics Observatory, the Ethics
      Education Programme and the Assisting Bioethics Committees project.
FAU - ten Have, Henk A M J
AU  - ten Have HA
AD  - Division of Ethics of Science and Technology, UNESCO, 75015 Paris, France.
      h.tenhave@unesco.org
LA  - eng
PT  - Journal Article
DEP - 20090821
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Bioethics/education
MH  - Curriculum
MH  - Databases as Topic/organization & administration
MH  - Double Effect Principle
MH  - Ethics Committees/ethics/organization & administration
MH  - Guidelines as Topic
MH  - *Human Rights/education/legislation & jurisprudence
MH  - Humans
MH  - Interdisciplinary Communication
MH  - Internationality
MH  - Organizational Objectives
MH  - Principle-Based Ethics
MH  - Science/*ethics
MH  - Technology/*ethics
MH  - United Nations/*ethics/organization & administration
EDAT- 2009/08/22 09:00
MHDA- 2010/07/02 06:00
CRDT- 2009/08/22 09:00
PHST- 2007/10/16 00:00 [received]
PHST- 2007/12/20 00:00 [accepted]
PHST- 2009/08/22 09:00 [entrez]
PHST- 2009/08/22 09:00 [pubmed]
PHST- 2010/07/02 06:00 [medline]
AID - 10.1007/s11948-009-9161-2 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2010 Mar;16(1):7-15. doi: 10.1007/s11948-009-9161-2. Epub 2009
      Aug 21.


PMID- 19697040
OWN - NLM
STAT- MEDLINE
DCOM- 20100426
LR  - 20211020
IS  - 1432-1084 (Electronic)
IS  - 0938-7994 (Linking)
VI  - 20
IP  - 2
DP  - 2010 Feb
TI  - MR imaging-guided cryoablation of metastatic brain tumours: initial experience in
      six patients.
PG  - 404-9
LID - 10.1007/s00330-009-1554-8 [doi]
AB  - OBJECTIVE: The objective was to evaluate the initial experience and safety of
      magnetic resonance imaging (MRI)-guided transcranial cryoablation in cystic
      metastatic brain tumours. MATERIAL AND METHODS: Seven cystic metastatic brain
      tumours in six patients were treated with cryoablation. The approval from the
      local ethics committee and individual patient consent were acquired before the
      study. Before the procedure the tumours were detected with conventional CT or
      MRI. The procedure was performed under local anaesthesia and conscious sedation. 
      A 0.23-T open MRI system with optical tracking was used for procedural planning, 
      instrument guidance and procedural monitoring of the ice ball formation. An
      MR-compatible, argon-based cryoablation system was used. The schedule of
      follow-up imaging ranged from 12 days to 12 months. RESULTS: Seven treatment
      sessions were performed. All the cryoprobes were successfully inserted into the
      target with one pass. All the patients tolerated the procedure well without
      experiencing any neurological deficits during the treatment phase or during the
      immediate post-treatment period. One patient died 12 days after cryoablation.
      CONCLUSION: MR-guided and monitored metastasis brain tumour cryoablation is
      technically feasible and may represent an alternative treatment in selected
      patients.
FAU - Li, Chengli
AU  - Li C
AD  - Shandong Provincial Medical Imaging Research Institute, Shandong University,
      Jinan, Shandong, People's Republic of China.
FAU - Wu, Lebin
AU  - Wu L
FAU - Song, Jiqing
AU  - Song J
FAU - Liu, Ming
AU  - Liu M
FAU - Lv, Yubo
AU  - Lv Y
FAU - Sequeiros, Roberto Blanco
AU  - Sequeiros RB
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20090821
PL  - Germany
TA  - Eur Radiol
JT  - European radiology
JID - 9114774
SB  - IM
MH  - Brain Neoplasms/pathology/*secondary/*surgery
MH  - Cryosurgery/*methods
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - Surgery, Computer-Assisted/*methods
MH  - Treatment Outcome
EDAT- 2009/08/22 09:00
MHDA- 2010/04/27 06:00
CRDT- 2009/08/22 09:00
PHST- 2009/03/25 00:00 [received]
PHST- 2009/07/05 00:00 [accepted]
PHST- 2009/06/24 00:00 [revised]
PHST- 2009/08/22 09:00 [entrez]
PHST- 2009/08/22 09:00 [pubmed]
PHST- 2010/04/27 06:00 [medline]
AID - 10.1007/s00330-009-1554-8 [doi]
PST - ppublish
SO  - Eur Radiol. 2010 Feb;20(2):404-9. doi: 10.1007/s00330-009-1554-8. Epub 2009 Aug
      21.


PMID- 19696093
OWN - NLM
STAT- MEDLINE
DCOM- 20100222
LR  - 20220408
IS  - 1460-2369 (Electronic)
IS  - 1355-4786 (Linking)
VI  - 16
IP  - 1
DP  - 2010 Jan-Feb
TI  - Paternal age and reproduction.
PG  - 65-79
LID - 10.1093/humupd/dmp027 [doi]
AB  - BACKGROUND: Due to various sociological factors, couples in developed countries
      are increasingly delaying childbearing. Besides ethical, economical and
      sociological issues, this trend presents us with several complex problems in
      reproduction. Although it is well-known that maternal age has a negative effect
      on fertility and increases the risk of adverse outcome during pregnancy and in
      offspring, the paternal influence on these outcomes is less well researched and
      not well-known. METHODS: We performed a systematic search of PubMed, and
      retrieved original articles and review articles to update our previous survey in 
      this journal. RESULTS: This review highlights the link between male age and
      genetic abnormalities in the germ line and summarizes the knowledge about the
      effects of paternal age on reproductive function and outcome. Increasing paternal
      age can be associated with decreasing androgen levels, decreased sexual activity,
      alterations of testicular morphology and a deterioration of semen quality
      (volume, motility, morphology). Increased paternal age has an influence on DNA
      integrity of sperm, increases telomere length in spermatozoa and is suggested to 
      have epigenetic effects. These changes may, at least in part, be responsible for 
      the association of paternal age over 40 years with reduced fertility, an increase
      in pregnancy-associated complications and adverse outcome in the offspring.
      CONCLUSION: Although higher maternal age can be an indication for intensive
      prenatal diagnosis, including invasive diagnostics, consideration of the
      available evidence suggests that paternal age itself, however, provides no
      rationale for invasive procedures.
FAU - Sartorius, Gideon A
AU  - Sartorius GA
AD  - Centre of Reproductive Medicine and Andrology of the University, Muenster,
      Germany.
FAU - Nieschlag, Eberhard
AU  - Nieschlag E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Hum Reprod Update
JT  - Human reproduction update
JID - 9507614
RN  - 0 (Hormones)
SB  - IM
MH  - Age Factors
MH  - Chromosome Aberrations
MH  - Female
MH  - Fertility
MH  - Hormones/metabolism
MH  - Humans
MH  - Male
MH  - *Paternal Age
MH  - Pregnancy
MH  - Pregnancy Complications/epidemiology
MH  - Pregnancy Outcome/epidemiology/genetics
MH  - Semen Analysis
MH  - Socioeconomic Factors
MH  - Testis/pathology
RF  - 209
EDAT- 2009/08/22 09:00
MHDA- 2010/02/23 06:00
CRDT- 2009/08/22 09:00
PHST- 2009/08/22 09:00 [entrez]
PHST- 2009/08/22 09:00 [pubmed]
PHST- 2010/02/23 06:00 [medline]
AID - dmp027 [pii]
AID - 10.1093/humupd/dmp027 [doi]
PST - ppublish
SO  - Hum Reprod Update. 2010 Jan-Feb;16(1):65-79. doi: 10.1093/humupd/dmp027.


PMID- 19694937
OWN - NLM
STAT- MEDLINE
DCOM- 20100520
LR  - 20220111
IS  - 0022-4006 (Print)
IS  - 0022-4006 (Linking)
VI  - 70
IP  - 1
DP  - 2010 Winter
TI  - Institutional review board and regulatory solutions in the dental PBRN.
PG  - 19-27
LID - 10.1111/j.1752-7325.2009.00139.x [doi]
AB  - OBJECTIVES: Effectively addressing regulatory and human participant protection
      issues with Institutional Review Boards (IRBs, or ethics committees) and grants
      administration entities is an important component of conducting research in large
      collaborative networks. A dental practice-based research network called "DPBRN"
      (http://www.DPBRN.org) comprises dentists in two health maintenance
      organizations, several universities, seven US states, and three Scandinavian
      countries. Our objectives are to describe: a) the various human participants and 
      regulatory requirements and solutions for each of DPBRN's five regions; b) their 
      impact on study protocols and implementation; and c) lessons learned from this
      process. METHODS: Following numerous discussions with IRB and grants
      administrative personnel for each region, some practitioner-investigators are
      attached to their respective IRBs and contracting entities via sub-contracts
      between their organizations and the network's administrative site. Others are
      attached via Individual Investigator Agreements and contractually obligated via
      Memoranda of Agreement. RESULTS: IRBs approve general operations under one
      approval, but specific research projects via separate approvals. Various formal
      IRB and grants administrative agreements have been arranged to customize research
      to the network context. In some instances, this occurred after feedback from
      patients and practitioners that lengthy written consent forms impeded research
      and raised suspicion, instead of decreasing it. CONCLUSIONS: Instead of viewing
      IRBs and institutional administrators as potentially adversarial, customized
      solutions can be identified by engaging them in collegial discussions that
      identify common ground within regulatory bounds. Although time-intensive and
      complex, these solutions improve acceptability of practice-based research to
      patients, practitioners, and university researchers.
FAU - Gilbert, Gregg H
AU  - Gilbert GH
AD  - Department of Diagnostic Sciences, School of Dentistry, University of Alabama at 
      Birmingham, AL 35294-0007, USA. ghg@uab.edu
FAU - Qvist, Vibeke
AU  - Qvist V
FAU - Moore, Sheila D
AU  - Moore SD
FAU - Rindal, D Brad
AU  - Rindal DB
FAU - Fellows, Jeffrey L
AU  - Fellows JL
FAU - Gordan, Valeria V
AU  - Gordan VV
FAU - Williams, O Dale
AU  - Williams OD
CN  - DPBRN Collaborative Group
LA  - eng
GR  - DE-16746/DE/NIDCR NIH HHS/United States
GR  - U01 DE016746/DE/NIDCR NIH HHS/United States
GR  - U01 DE016746-05/DE/NIDCR NIH HHS/United States
GR  - DE-16747/DE/NIDCR NIH HHS/United States
GR  - U01 DE016747/DE/NIDCR NIH HHS/United States
GR  - U01 DE016747-05/DE/NIDCR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Public Health Dent
JT  - Journal of public health dentistry
JID - 0014207
SB  - IM
MH  - Clinical Trials as Topic/ethics/legislation & jurisprudence
MH  - *Computer Communication Networks
MH  - Dental Research/ethics/legislation & jurisprudence/*organization & administration
MH  - Ethics Committees, Research/*organization & administration
MH  - Financing, Government/ethics/legislation & jurisprudence
MH  - *Government Regulation
MH  - Humans
MH  - Informed Consent
MH  - Research Subjects/legislation & jurisprudence
MH  - Scandinavian and Nordic Countries
MH  - United States
PMC - PMC2864321
MID - NIHMS172210
EDAT- 2009/08/22 09:00
MHDA- 2010/05/21 06:00
CRDT- 2009/08/22 09:00
PHST- 2009/08/22 09:00 [entrez]
PHST- 2009/08/22 09:00 [pubmed]
PHST- 2010/05/21 06:00 [medline]
AID - JPHD139 [pii]
AID - 10.1111/j.1752-7325.2009.00139.x [doi]
PST - ppublish
SO  - J Public Health Dent. 2010 Winter;70(1):19-27. doi:
      10.1111/j.1752-7325.2009.00139.x.


PMID- 19694781
OWN - NLM
STAT- MEDLINE
DCOM- 20100819
LR  - 20211020
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 10
IP  - 2
DP  - 2010 Aug
TI  - Curriculum guide for research ethics workshops for countries in the Middle East.
PG  - 70-7
LID - 10.1111/j.1471-8847.2009.00261.x [doi]
AB  - To help ensure the ethical conduct of research, many have recommended educational
      efforts in research ethics to investigators and members of research ethics
      committees (RECs). One type of education activity involves multi-day workshops in
      research ethics. To be effective, such workshops should contain the appropriate
      content and teaching techniques geared towards the learning styles of the
      targeted audiences. To ensure consistency in content and quality, we describe the
      development of a curriculum guide, core competencies and associated learning
      objectives and activities to help educators organize research ethics workshops in
      their respective institutions. The curriculum guide is divided into modular units
      to enable planners to develop workshops of different lengths and choose content
      materials that match the needs, abilities, and prior experiences of the target
      audiences. The content material in the curriculum guide is relevant for audiences
      in the Middle East, because individuals from the Middle East who participated in 
      a Certificate Program in research ethics selected and developed the training
      materials (e.g., articles, PowerPoint slides, case studies, protocols). Also,
      many of the activities incorporate active-learning methods, consisting of group
      work activities analyzing case studies and reviewing protocols. The development
      of such a workshop training curriculum guide represents a sustainable educational
      resource to enhance research ethics capacity in the Middle East.
FAU - Silverman, Henry
AU  - Silverman H
AD  - Department of Medicine, University of Maryland, 110 S. Paca Street, Baltimore, MD
      21201, United States. hsilverm@medicine.umaryland.edu
FAU - Ahmed, Babiker
AU  - Ahmed B
FAU - Ajeilet, Samar
AU  - Ajeilet S
FAU - Al-Fadil, Sumaia
AU  - Al-Fadil S
FAU - Al-Amad, Suhail
AU  - Al-Amad S
FAU - El-Dessouky, Hadir
AU  - El-Dessouky H
FAU - El-Gendy, Ibrahim
AU  - El-Gendy I
FAU - El-Guindi, Mohamed
AU  - El-Guindi M
FAU - El-Nimeiri, Mustafa
AU  - El-Nimeiri M
FAU - Muzaffar, Rana
AU  - Muzaffar R
FAU - Saleh, Azza
AU  - Saleh A
LA  - eng
GR  - R25 TW007090/TW/FIC NIH HHS/United States
GR  - R25 TW007090-04S2/TW/FIC NIH HHS/United States
GR  - 25TW007090/TW/FIC NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20090818
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
SB  - IM
MH  - *Curriculum
MH  - Education/organization & administration
MH  - Ethics, Research/*education
MH  - Humans
MH  - Learning
MH  - Middle East
MH  - *Programmed Instructions as Topic
MH  - Teaching/*methods
PMC - PMC2891165
MID - NIHMS141736
EDAT- 2009/08/22 09:00
MHDA- 2010/08/20 06:00
CRDT- 2009/08/22 09:00
PHST- 2009/08/22 09:00 [entrez]
PHST- 2009/08/22 09:00 [pubmed]
PHST- 2010/08/20 06:00 [medline]
AID - DEWB261 [pii]
AID - 10.1111/j.1471-8847.2009.00261.x [doi]
PST - ppublish
SO  - Dev World Bioeth. 2010 Aug;10(2):70-7. doi: 10.1111/j.1471-8847.2009.00261.x.
      Epub 2009 Aug 18.


PMID- 19690974
OWN - NLM
STAT- MEDLINE
DCOM- 20100518
LR  - 20211020
IS  - 1573-9368 (Electronic)
IS  - 0962-8819 (Linking)
VI  - 19
IP  - 2
DP  - 2010 Apr
TI  - "What's wrong with my monkey?" Ethical perspectives on germline transgenesis in
      marmosets.
PG  - 181-6
LID - 10.1007/s11248-009-9316-6 [doi]
AB  - The birth of the first transgenic primate to have inherited a transgene from its 
      parents opens the possibility to set up transgenic marmoset colonies, as these
      monkeys are small and relatively easy to keep and breed in research facilities.
      The prospect of transgenic marmoset models of human disease, readily available in
      the way that transgenic laboratory mice are currently, prompts excitement in the 
      scientific community; but the idea of monkeys being bred to carry diseases is
      also contentious. We structure an ethical analysis of the transgenic marmoset
      case around three questions: whether it is acceptable to use animals as models of
      human disease; whether it is acceptable to genetically modify animals; and
      whether these animals' being monkeys makes a difference. The analysis considers
      the prospect of transgenic marmoset studies coming to replace transgenic mouse
      studies and lesion studies in marmosets in some areas of research. The
      mainstream, broadly utilitarian view of animal research suggests that such a
      transition will not give rise to greater ethical problems than those presently
      faced. It can be argued that using marmosets rather than mice will not result in 
      more animal suffering, and that the benefits of research will improve with a move
      to a species more similar in phylogenetic terms to humans. The biological and
      social proximity of monkeys and humans may also benefit the animals by making it 
      easier for scientists and caretakers to recognize signs of suffering and
      increasing the human motivation to limit it. The animal welfare and research
      impacts of the transition to marmoset use will depend very much on the extent to 
      which researchers take these issues seriously and seek to minimize animal harm
      and optimize human benefit.
FAU - Olsson, I Anna S
AU  - Olsson IA
AD  - Laboratory Animal Science, IBMC-Instituto de Biologia Molecular e Celular,
      Universidade do Porto, Rua do Campo Alegre 823, 4150-180 Porto, Portugal.
      olsson@ibmc.up.pt
FAU - Sandoe, Peter
AU  - Sandoe P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20090819
PL  - Netherlands
TA  - Transgenic Res
JT  - Transgenic research
JID - 9209120
SB  - IM
MH  - Animals
MH  - Animals, Genetically Modified/*genetics
MH  - Bioethics
MH  - Biomedical Research/*ethics
MH  - Callithrix/*genetics
MH  - *Disease Models, Animal
MH  - Genetic Engineering/*ethics/methods
MH  - Germ Cells/*metabolism
MH  - Humans
MH  - Transgenes/genetics
RF  - 26
EDAT- 2009/08/20 09:00
MHDA- 2010/05/19 06:00
CRDT- 2009/08/20 09:00
PHST- 2009/07/08 00:00 [received]
PHST- 2009/07/31 00:00 [accepted]
PHST- 2009/08/20 09:00 [entrez]
PHST- 2009/08/20 09:00 [pubmed]
PHST- 2010/05/19 06:00 [medline]
AID - 10.1007/s11248-009-9316-6 [doi]
PST - ppublish
SO  - Transgenic Res. 2010 Apr;19(2):181-6. doi: 10.1007/s11248-009-9316-6. Epub 2009
      Aug 19.


PMID- 19690788
OWN - NLM
STAT- MEDLINE
DCOM- 20100902
LR  - 20211020
IS  - 1433-9285 (Electronic)
IS  - 0933-7954 (Linking)
VI  - 45
IP  - 8
DP  - 2010 Aug
TI  - Involuntary commitment and detainment in adolescent psychiatric inpatient care.
PG  - 785-93
LID - 10.1007/s00127-009-0116-3 [doi]
AB  - OBJECTIVE: To evaluate whether adolescents committed to psychiatric inpatient
      care are the most disturbed, and whether psychosocial factors other than
      psychiatric symptoms are associated with commitment to and detainment in
      psychiatric care among adolescents. MATERIALS AND METHODS: The case histories of 
      187 13- to 17-year-old adolescents consecutively admitted to the study clinic
      were scrutinized with the help of a structured data collection form. Psychiatric,
      demographic and family-related characteristics of those referred involuntarily (n
      = 93) and voluntarily (n = 94), and those detained involuntarily (n = 42) and
      treated on a voluntary basis (n = 145) were compared. RESULTS: Involuntary
      referral and involuntary detainment were associated with psychotic symptoms,
      temper tantrums and breaking property, involuntary referral also with violent and
      hostile behaviours and suicidal ideation and talk. They were not associated to
      family adversities, previous treatment history or sociodemographic factors. The
      risk for being committed when presenting with aggressive behaviours was greater
      in girls. CONCLUSION: Involuntary referral and detainment in adolescents is
      associated with symptom severity, and not with aspects of the adolescent's living
      conditions. This is in agreement with the legislation. Gender bias resulting in
      girls' greater risk of being involuntarily committed if displaying aggressive
      behaviours may be an ethical and legal problem.
FAU - Kaltiala-Heino, Riittakerttu
AU  - Kaltiala-Heino R
AD  - Department of Adolescent Psychiatry, Tampere University Hospital, 33380,
      Pitkaniemi, Finland, merihe@uta.fi.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20090819
PL  - Germany
TA  - Soc Psychiatry Psychiatr Epidemiol
JT  - Social psychiatry and psychiatric epidemiology
JID - 8804358
SB  - IM
MH  - Adolescent
MH  - Adolescent Behavior/psychology
MH  - Adolescent Psychiatry/*statistics & numerical data
MH  - Aggression/psychology
MH  - Behavioral Symptoms/diagnosis/epidemiology
MH  - Child
MH  - Commitment of Mentally Ill/legislation & jurisprudence/*statistics & numerical
      data
MH  - Female
MH  - Finland/epidemiology
MH  - Health Services Research/statistics & numerical data
MH  - Hospitalization/legislation & jurisprudence/*statistics & numerical data
MH  - Humans
MH  - Male
MH  - Mental Disorders/*diagnosis/epidemiology/therapy
MH  - Prevalence
MH  - Referral and Consultation/*statistics & numerical data
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Sex Factors
MH  - Suicide, Attempted/psychology
EDAT- 2009/08/20 09:00
MHDA- 2010/09/03 06:00
CRDT- 2009/08/20 09:00
PHST- 2009/01/14 00:00 [received]
PHST- 2009/07/31 00:00 [accepted]
PHST- 2009/08/20 09:00 [entrez]
PHST- 2009/08/20 09:00 [pubmed]
PHST- 2010/09/03 06:00 [medline]
AID - 10.1007/s00127-009-0116-3 [doi]
PST - ppublish
SO  - Soc Psychiatry Psychiatr Epidemiol. 2010 Aug;45(8):785-93. doi:
      10.1007/s00127-009-0116-3. Epub 2009 Aug 19.


PMID- 19688402
OWN - NLM
STAT- MEDLINE
DCOM- 20100408
LR  - 20211020
IS  - 1432-2218 (Electronic)
IS  - 0930-2794 (Linking)
VI  - 24
IP  - 1
DP  - 2010 Jan
TI  - Quality assurance in flexible sigmoidoscopy: medical and nonmedical endoscopists.
PG  - 89-93
LID - 10.1007/s00464-009-0553-9 [doi]
AB  - PURPOSE: The clinical assessment of position in colon and hence completion during
      flexible sigmoidoscopy (FS) is believed to be inaccurate. The technique of
      applying endomucosal clips with follow-up X-ray has previously been used for
      establishing completion in colonoscopy. Furthermore, we have now trained
      non-healthcare professionals (non-medical endoscopists, NME) to perform FS, but
      there is no data on assessment of their performance of FS. We performed this
      study with the aims of determining accuracy of endoscopists' clinical impression 
      regarding actual position of endoscope in colon during FS, comparing medical (ME)
      and NME in terms of clinical accuracy, and to determine role of endomucosal clips
      with follow-up X-rays in documenting completion and hence quality assurance.
      METHODS: All patients undergoing elective FS, except those with surgical
      resection, were included, after ethics approval. During FS, endoscopist applied
      an endomucosal clip at most proximal bowel reached and endoscopists recorded
      their independent opinion about position of clip. Post procedure, all patients
      underwent an abdominal X-ray, reported by consultant radiologist, blinded to
      outcome of FS. X-ray results were compared with endoscopist findings. Complete FS
      was defined as one where descending colon was reached. RESULTS: Fifty-one
      patients, with median age of 55 years, participated in study. The endoscopists
      were accurate in their assessment of position in colon in 38 patients (75%). The 
      attending nurse was accurate in only 31% of cases. The crude and corrected
      completion rates were 73% and 84%, respectively. There was no correlation between
      length of endoscope and its position in colon. There were no differences between 
      NME and ME in terms of clinical accuracy. CONCLUSION: This study has shown that
      clinical impression of endoscopist during FS regarding position is not very
      accurate, implying need for regular quality assurance. The technique of applying 
      endomucosal clips with follow-on abdominal X-ray is an excellent objective
      measure of quality assurance in FS. NME can perform FS with comparable completion
      rates and accuracy.
FAU - Maslekar, Sushil
AU  - Maslekar S
AD  - Academic Surgical Unit, Castle Hill Hospital, University of Hull, East Yorkshire,
      UK. s.maslekar@hull.ac.uk
FAU - Waudby, Philip
AU  - Waudby P
FAU - Avery, Ged
AU  - Avery G
FAU - Monson, J R T
AU  - Monson JR
FAU - Duthie, Graeme Scott
AU  - Duthie GS
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20090818
PL  - Germany
TA  - Surg Endosc
JT  - Surgical endoscopy
JID - 8806653
SB  - IM
MH  - Adult
MH  - Aged
MH  - Colon/*anatomy & histology
MH  - Colon, Sigmoid/anatomy & histology
MH  - Colonic Diseases/*diagnosis
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - *Quality Assurance, Health Care
MH  - Sigmoidoscopes
MH  - *Sigmoidoscopy
MH  - Surgical Instruments
EDAT- 2009/08/19 09:00
MHDA- 2010/04/09 06:00
CRDT- 2009/08/19 09:00
PHST- 2008/12/04 00:00 [received]
PHST- 2009/04/28 00:00 [accepted]
PHST- 2009/04/18 00:00 [revised]
PHST- 2009/08/19 09:00 [entrez]
PHST- 2009/08/19 09:00 [pubmed]
PHST- 2010/04/09 06:00 [medline]
AID - 10.1007/s00464-009-0553-9 [doi]
PST - ppublish
SO  - Surg Endosc. 2010 Jan;24(1):89-93. doi: 10.1007/s00464-009-0553-9. Epub 2009 Aug 
      18.


PMID- 19683715
OWN - NLM
STAT- MEDLINE
DCOM- 20100512
LR  - 20220316
IS  - 1873-491X (Electronic)
IS  - 0020-7489 (Linking)
VI  - 47
IP  - 3
DP  - 2010 Mar
TI  - Quality of faculty, students, curriculum and resources for nursing doctoral
      education in Korea: a focus group study.
PG  - 295-306
LID - 10.1016/j.ijnurstu.2009.07.005 [doi]
AB  - BACKGROUND: The rapidly increasing number of nursing doctoral programs has caused
      concern about the quality of nursing doctoral education, including in Korea.
      OBJECTIVES: To describe the perceived quality of Korean nursing doctoral
      education in faculty, student, curriculum and resources. DESIGN: Focus group.
      SETTINGS: Fourteen Korean nursing doctoral programs that are research focused and
      include coursework. PARTICIPANTS: Four groups of deans, faculty, students and
      graduates; students completed three semesters of doctoral program; and graduates 
      completed doctoral programs within the most recent 3 years. METHODS: Focus groups
      examined the strengths and weaknesses of faculty, students, curriculum, and
      resources. RESULTS: Faculty strengths were universities' recognition of faculty
      research/scholarship and the ability of faculty to attract extramural funding.
      Faculty weaknesses were aging faculty; high faculty workload; insufficient number
      of faculty; and teaching without expertise in nursing theories. Student strengths
      were diverse student backgrounds; multidisciplinary dissertation committee
      members, and opportunities to socialize with peers and graduates/faculty.
      Students' weaknesses were overproduction of PhDs with low academic quality; a
      lower number and quality of doctoral applicants; and lack of full-time students. 
      Curriculum strengths were focusing on specific research areas; emphasis on
      research ethics; and multidisciplinary courses. Curriculum weaknesses were
      insufficient time for curriculum development; inadequate courses for core
      research competencies; and a lack of linkage between theory and practice.
      Resources strengths were inter-institutional courses with credit transfer.
      Weaknesses were diminished university financial support for graduate students and
      limited access to school facilities. Variations in participant groups (providers 
      [deans and faculty] vs. receivers [students and graduates]) and geographical
      location (capital city vs. regional) were noted on all the four components.
      CONCLUSIONS: The quality characteristics of faculty, students, curriculum, and
      resources identified in this first systematic evaluation of the quality of
      nursing doctoral education can inform nursing schools, universities, and
      policy-makers about areas for improvement in Korea and possibly in the world.
      Geographical variations found in these four components of doctoral education
      warrant attention by policy-makers in Korea.
CI  - Copyright 2009 Elsevier Ltd. All rights reserved.
FAU - Kim, Mi Ja
AU  - Kim MJ
AD  - University of Illinois at Chicago, College of Nursing, Chicago, IL 60612, USA.
FAU - Lee, Hyeonkyeong
AU  - Lee H
FAU - Kim, Hyun Kyung
AU  - Kim HK
FAU - Ahn, Yang-Heui
AU  - Ahn YH
FAU - Kim, Euisook
AU  - Kim E
FAU - Yun, Soon-Nyoung
AU  - Yun SN
FAU - Lee, Kwang-Ja
AU  - Lee KJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090815
PL  - England
TA  - Int J Nurs Stud
JT  - International journal of nursing studies
JID - 0400675
SB  - IM
MH  - Academic Dissertations as Topic
MH  - Adult
MH  - Age Factors
MH  - *Attitude of Health Personnel
MH  - *Curriculum/standards
MH  - Education, Nursing, Graduate/*organization & administration
MH  - *Faculty, Nursing/standards
MH  - Focus Groups
MH  - Health Services Needs and Demand
MH  - Humans
MH  - Korea
MH  - Middle Aged
MH  - Nurse Administrators/*psychology
MH  - Nursing Education Research
MH  - Nursing Methodology Research
MH  - Professional Competence
MH  - Qualitative Research
MH  - Students, Nursing/*psychology
MH  - Training Support
MH  - Workload
EDAT- 2009/08/18 09:00
MHDA- 2010/05/13 06:00
CRDT- 2009/08/18 09:00
PHST- 2009/01/17 00:00 [received]
PHST- 2009/07/18 00:00 [revised]
PHST- 2009/07/20 00:00 [accepted]
PHST- 2009/08/18 09:00 [entrez]
PHST- 2009/08/18 09:00 [pubmed]
PHST- 2010/05/13 06:00 [medline]
AID - S0020-7489(09)00258-2 [pii]
AID - 10.1016/j.ijnurstu.2009.07.005 [doi]
PST - ppublish
SO  - Int J Nurs Stud. 2010 Mar;47(3):295-306. doi: 10.1016/j.ijnurstu.2009.07.005.
      Epub 2009 Aug 15.


PMID- 19682989
OWN - NLM
STAT- MEDLINE
DCOM- 20100416
LR  - 20220318
IS  - 1090-2430 (Electronic)
IS  - 0014-4886 (Linking)
VI  - 223
IP  - 1
DP  - 2010 May
TI  - Mesenchymal stem cell transplantation in amyotrophic lateral sclerosis: A Phase I
      clinical trial.
PG  - 229-37
LID - 10.1016/j.expneurol.2009.08.007 [doi]
AB  - Amyotrophic Lateral Sclerosis (ALS) is a devastating incurable disease.
      Stem-cell-based therapies represent a new possible strategy for ALS clinical
      research. The objectives of this Phase 1 clinical study were to assess the
      feasibility and toxicity of mesenchymal stem cell transplantation and to test the
      impact of a cell therapy in ALS patients. The trial was approved and monitored by
      the National Institute of Health and by the Ethics Committees of all
      participating Institutions. Autologous MSCs were isolated from bone marrow,
      expanded in vitro and analyzed according to GMP conditions. Expanded MSCs were
      suspended in the autologous cerebrospinal fluid (CSF) and directly transplanted
      into the spinal cord at a high thoracic level with a surgical procedure. Ten ALS 
      patients were enrolled and regularly monitored before and after transplantation
      by clinical, psychological, neuroradiological and neurophysiological assessments.
      There was no immediate or delayed transplant-related toxicity. Clinical,
      laboratory, and radiographic evaluations of the patients showed no serious
      transplant-related adverse events. Magnetic resonance images (MRI) showed no
      structural changes (including tumor formation) in either the brain or the spinal 
      cord. However the lack of post mortem material prevents any definitive conclusion
      about the vitality of the MSCs after transplantation. In conclusion, this study
      confirms that MSC transplantation into the spinal cord of ALS patients is safe
      and that MSCs might have a clinical use for future ALS cell based clinical
      trials.
CI  - Copyright 2009 Elsevier Inc. All rights reserved.
FAU - Mazzini, L
AU  - Mazzini L
AD  - Department of Neurology Eastern Piedmont University, Maggiore della Carita
      Hospital, 28100 Novara, Italy. mazzini.l@libero.it
FAU - Ferrero, I
AU  - Ferrero I
FAU - Luparello, V
AU  - Luparello V
FAU - Rustichelli, D
AU  - Rustichelli D
FAU - Gunetti, M
AU  - Gunetti M
FAU - Mareschi, K
AU  - Mareschi K
FAU - Testa, L
AU  - Testa L
FAU - Stecco, A
AU  - Stecco A
FAU - Tarletti, R
AU  - Tarletti R
FAU - Miglioretti, M
AU  - Miglioretti M
FAU - Fava, E
AU  - Fava E
FAU - Nasuelli, N
AU  - Nasuelli N
FAU - Cisari, C
AU  - Cisari C
FAU - Massara, M
AU  - Massara M
FAU - Vercelli, R
AU  - Vercelli R
FAU - Oggioni, G D
AU  - Oggioni GD
FAU - Carriero, A
AU  - Carriero A
FAU - Cantello, R
AU  - Cantello R
FAU - Monaco, F
AU  - Monaco F
FAU - Fagioli, F
AU  - Fagioli F
LA  - eng
PT  - Clinical Trial, Phase I
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090813
PL  - United States
TA  - Exp Neurol
JT  - Experimental neurology
JID - 0370712
RN  - 0 (Antigens, CD)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Amyotrophic Lateral Sclerosis/physiopathology/*surgery
MH  - Antigens, CD/metabolism
MH  - Bone Marrow Cells/physiology
MH  - Cohort Studies
MH  - Diffusion Magnetic Resonance Imaging/methods
MH  - Electric Stimulation/methods
MH  - Evoked Potentials, Somatosensory/physiology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Mesenchymal Stem Cell Transplantation/*methods
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Spinal Cord/pathology
MH  - Time Factors
MH  - Young Adult
EDAT- 2009/08/18 09:00
MHDA- 2010/04/17 06:00
CRDT- 2009/08/18 09:00
PHST- 2009/03/11 00:00 [received]
PHST- 2009/07/31 00:00 [revised]
PHST- 2009/08/02 00:00 [accepted]
PHST- 2009/08/18 09:00 [entrez]
PHST- 2009/08/18 09:00 [pubmed]
PHST- 2010/04/17 06:00 [medline]
AID - S0014-4886(09)00317-3 [pii]
AID - 10.1016/j.expneurol.2009.08.007 [doi]
PST - ppublish
SO  - Exp Neurol. 2010 May;223(1):229-37. doi: 10.1016/j.expneurol.2009.08.007. Epub
      2009 Aug 13.


PMID- 19678901
OWN - NLM
STAT- MEDLINE
DCOM- 20100216
LR  - 20220310
IS  - 1432-2277 (Electronic)
IS  - 0934-0874 (Linking)
VI  - 23
IP  - 1
DP  - 2010 Jan
TI  - Should we perform heart retransplantation in early graft failure?
PG  - 47-53
LID - 10.1111/j.1432-2277.2009.00945.x [doi]
AB  - Cardiac retransplantation represents the gold standard treatment for a failing
      cardiac graft but the decision to offer the patient a second chance is often made
      difficult by both lack of donors and the ethical issues involved. The aim of this
      study was to evaluate whether retransplantation is a reasonable option in case of
      early graft failure. Between November 1985 and June 2008, 922 patients underwent 
      cardiac transplantation at our Institution. Of these, 37 patients (4%) underwent 
      cardiac retransplantation for cardiac failure resulting from early graft failure 
      (n = 11) or late graft failure (acute rejection: n = 2, transplant-related
      coronary artery disease: n = 24). Survival at 1, 5 and 10 years of patients with 
      retransplantation was 59%, 50% and 40% respectively. An interval between the
      first and the second transplantation of less than (n = 11, all in early graft
      failure) or more than (n = 26) 1 month was associated with a 1-year survival of
      27% and 73%, and a 5-year survival of 27% and 65% respectively (P = 0.01). The
      long-term outcome of cardiac retransplantation is comparable with that of primary
      transplantation only in patients with transplant-related coronary artery disease.
      Early graft failure is a significant risk factor for survival after cardiac
      retransplantation and should be considered as an exclusion criteria.
FAU - Vistarini, Nicola
AU  - Vistarini N
AD  - Department of Cardiac Surgery and Thoracic Transplantation, Fondazione IRCCS
      Policlinico San Matteo, Pavia, Italy. nvistar@tin.it
FAU - Pellegrini, Carlo
AU  - Pellegrini C
FAU - Aiello, Marco
AU  - Aiello M
FAU - Alloni, Alessia
AU  - Alloni A
FAU - Monterosso, Cristian
AU  - Monterosso C
FAU - Cattadori, Barbara
AU  - Cattadori B
FAU - Tinelli, Carmine
AU  - Tinelli C
FAU - D'Armini, Andrea M
AU  - D'Armini AM
FAU - Vigano, Mario
AU  - Vigano M
LA  - eng
PT  - Journal Article
DEP - 20090812
PL  - Switzerland
TA  - Transpl Int
JT  - Transplant international : official journal of the European Society for Organ
      Transplantation
JID - 8908516
SB  - IM
MH  - Adult
MH  - Aged
MH  - Contraindications
MH  - Coronary Artery Disease/etiology/surgery
MH  - Female
MH  - Graft Rejection/*surgery
MH  - Graft Survival
MH  - Heart Failure/surgery
MH  - Heart Transplantation/*adverse effects
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Patient Selection
MH  - Reoperation
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2009/08/15 09:00
MHDA- 2010/02/17 06:00
CRDT- 2009/08/15 09:00
PHST- 2009/08/15 09:00 [entrez]
PHST- 2009/08/15 09:00 [pubmed]
PHST- 2010/02/17 06:00 [medline]
AID - TRI945 [pii]
AID - 10.1111/j.1432-2277.2009.00945.x [doi]
PST - ppublish
SO  - Transpl Int. 2010 Jan;23(1):47-53. doi: 10.1111/j.1432-2277.2009.00945.x. Epub
      2009 Aug 12.


PMID- 19669937
OWN - NLM
STAT- MEDLINE
DCOM- 20100923
LR  - 20151119
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 16
IP  - 2
DP  - 2010 Jun
TI  - A new experience: the course of ethics in engineering in the Department of Civil 
      Engineering, University of Granada.
PG  - 409-13
LID - 10.1007/s11948-009-9156-z [doi]
AB  - A course in professional ethics for civil engineers was taught for the first time
      in Spain during the academic year 2007/08. In this paper a survey on the
      satisfaction and expectation of the course is presented. Surprisingly the
      students sought moral and ethical principles for their own ordinary lives as well
      as for their profession. Students were concerned about the law, but in their
      actions they were more concerned with their conscience, aware that it can be
      separate from the law.
FAU - Gil-Martin, Luisa Maria
AU  - Gil-Martin LM
AD  - School of Civil Engineering, University of Granada, Campus de Fuentenueva, 18072 
      Granada, Spain.
FAU - Hernandez-Montes, Enrique
AU  - Hernandez-Montes E
FAU - Segura-Naya, Armando
AU  - Segura-Naya A
LA  - eng
PT  - Journal Article
DEP - 20090811
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Attitude
MH  - *Curriculum/statistics & numerical data
MH  - Education, Graduate/*organization & administration
MH  - *Engineering/education/ethics
MH  - Esthetics/education
MH  - Ethics, Professional/*education
MH  - Humans
MH  - Morals
MH  - Needs Assessment
MH  - Principle-Based Ethics
MH  - Program Development
MH  - Program Evaluation
MH  - Religion
MH  - Spain
MH  - Students/*psychology/statistics & numerical data
MH  - Surveys and Questionnaires
EDAT- 2009/08/12 09:00
MHDA- 2010/09/24 06:00
CRDT- 2009/08/12 09:00
PHST- 2009/05/04 00:00 [received]
PHST- 2009/07/20 00:00 [accepted]
PHST- 2009/08/12 09:00 [entrez]
PHST- 2009/08/12 09:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
AID - 10.1007/s11948-009-9156-z [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2010 Jun;16(2):409-13. doi: 10.1007/s11948-009-9156-z. Epub 2009 
      Aug 11.


PMID- 19669136
OWN - NLM
STAT- MEDLINE
DCOM- 20100409
LR  - 20211020
IS  - 1432-2161 (Electronic)
IS  - 0364-2348 (Linking)
VI  - 39
IP  - 1
DP  - 2010 Jan
TI  - The developmental spectrum of proximal radioulnar synostosis.
PG  - 49-54
LID - 10.1007/s00256-009-0762-2 [doi]
AB  - OBJECTIVE: Proximal radioulnar synostosis is a rare upper limb malformation. The 
      elbow is first identifiable at 35 days (after conception), at which stage the
      cartilaginous anlagen of the humerus, radius and ulna are continuous.
      Subsequently, longitudinal segmentation produces separation of the distal radius 
      and ulna. However, temporarily, the proximal ends are united and continue to
      share a common perichondrium. We investigated the hypothesis that posterior
      congenital dislocation of the radial head and proximal radioulnar fusion are
      different clinical manifestations of the same primary developmental abnormality. 
      MATERIALS AND METHODS: Records were searched for "proximal radioulnar
      fusion/posterior radial head dislocation" in patients followed at the local
      Children's Hospital and Rehabilitation Centre for Children. Relevant
      radiographic, demographic and clinical data were recorded. Ethics approval was
      obtained through the University Research Ethics Board. RESULTS: In total, 28
      patients met the inclusion criteria. The majority of patients (16) had bilateral 
      involvement; eight with posterior dislocation of the radial head only; five had
      posterior radial head dislocation with radioulnar fusion and two had radioulnar
      fusion without dislocation. One patient had bilateral proximal radioulnar fusion 
      and posterior dislocation of the left radial head. Nine patients had only
      left-sided involvement, and three had only right-sided involvement.The degree of 
      proximal fusion varied, with some patients showing 'complete' proximal fusion and
      others showing fusion that occurred slightly distal to the radial head:
      'partially separated.' Associated disorders in our cohort included Poland
      syndrome (two patients), Cornelia de Lange syndrome, chromosome anomalies
      (including tetrasomy X) and Cenani Lenz syndactyly. CONCLUSION: The suggestion of
      a developmental relationship between posterior dislocation of the radial head and
      proximal radioulnar fusion is supported by the fact that both anomalies can occur
      in the same patient. Furthermore, both anomalies can be seen in different
      patients with the same genetic diagnosis, further supporting the notion that
      these defects are developmentally related. Posterior dislocation of the radial
      head and radioulnar fusion are considered to be related primary developmental
      anomalies of radioulnar differentiation/segmentation. We speculate that the
      eventual specific defect of this spectrum is influenced by very subtle
      differences in developmental timing. This is in contrast to patients with
      transverse forearm defects who can also display radial head dislocation but in an
      anterior or lateral direction. This direction of dislocation is seen when an
      abnormal force is exerted on a normally formed radial head later in development
      or postnatally in disorders such as multiple osteochondromatosis and various
      mesomelic dysplasias, or as a result of trauma.
FAU - Elliott, Alison M
AU  - Elliott AM
AD  - Winnipeg Regional Health Association Program of Genetics and Metabolism,
      University of Manitoba, Winnipeg, MB, Canada. aelliott@hsc.mb.ca
FAU - Kibria, Lisa
AU  - Kibria L
FAU - Reed, Martin H
AU  - Reed MH
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Skeletal Radiol
JT  - Skeletal radiology
JID - 7701953
SB  - IM
MH  - Bone Diseases, Developmental/diagnostic imaging/genetics/*pathology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - *Forearm/abnormalities/diagnostic imaging
MH  - Humans
MH  - Male
MH  - Radiography
MH  - Synostosis/*diagnostic imaging/genetics/*pathology
EDAT- 2009/08/12 09:00
MHDA- 2010/04/10 06:00
CRDT- 2009/08/12 09:00
PHST- 2009/05/26 00:00 [received]
PHST- 2009/07/13 00:00 [accepted]
PHST- 2009/07/08 00:00 [revised]
PHST- 2009/08/12 09:00 [entrez]
PHST- 2009/08/12 09:00 [pubmed]
PHST- 2010/04/10 06:00 [medline]
AID - 10.1007/s00256-009-0762-2 [doi]
PST - ppublish
SO  - Skeletal Radiol. 2010 Jan;39(1):49-54. doi: 10.1007/s00256-009-0762-2.


PMID- 19664311
OWN - NLM
STAT- MEDLINE
DCOM- 20100412
LR  - 20161020
IS  - 1741-203X (Electronic)
IS  - 1041-6102 (Linking)
VI  - 22
IP  - 2
DP  - 2010 Mar
TI  - Advance directives in dementia: issues of validity and effectiveness.
PG  - 201-8
LID - 10.1017/S1041610209990706 [doi]
AB  - BACKGROUND: Although advance directives may seem useful instruments in
      decision-making regarding incompetent patients, their validity in cases of
      dementia has been a much debated subject and little is known about their
      effectiveness in practice. This paper assesses the contribution of advance
      directives to decision-making in the care of people with dementia, with a special
      focus on non-treatment directives and directives for euthanasia. METHODS: The
      relevant problems from the ethical debate on advance directives in cases of
      dementia are summarized and we discuss how these relate to what is known from
      empirical research on the validity and effectiveness of advance directives in the
      clinical practice of dementia care. RESULTS: The ethical debate focuses
      essentially on how to respond to the current wishes of a patient with dementia if
      these contradict the patient's wishes contained in an advance directive. The
      (very limited) empirical data show that the main factors in medical
      decision-making in such cases is not the patient's perspective but the medical
      judgment of the physician and the influence of relatives. Insight into the
      experiences and wishes of people with dementia regarding advance directives is
      totally lacking in empirical research. CONCLUSIONS: Ethics and actual practice
      are two "different worlds" when it comes to approaching advance directives in
      cases of dementia. It is clear, however, that the use of advance directives in
      practice remains problematic, above all in cases of advance euthanasia
      directives, but to a lesser extent also when non-treatment directives are
      involved. Although generally considered valid, their effectiveness seems
      marginal. Further empirical research into the (potential) value of advance
      directives in dementia care is recommended.
FAU - de Boer, Marike E
AU  - de Boer ME
AD  - Department of Nursing Home Medicine, EMGO Institute for Health and Care Research,
      VU University Medical Center, Amsterdam, The Netherlands. m.deboer@vumc.nl
FAU - Hertogh, Cees M P M
AU  - Hertogh CM
FAU - Droes, Rose-Marie
AU  - Droes RM
FAU - Jonker, Cees
AU  - Jonker C
FAU - Eefsting, Jan A
AU  - Eefsting JA
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20090810
PL  - England
TA  - Int Psychogeriatr
JT  - International psychogeriatrics
JID - 9007918
SB  - IM
MH  - Advance Directive Adherence/ethics/psychology
MH  - *Advance Directives/ethics/legislation & jurisprudence/psychology
MH  - Aged
MH  - Decision Making
MH  - Dementia/psychology/*therapy
MH  - Euthanasia, Passive/psychology
MH  - Humans
MH  - Mental Competency/psychology
RF  - 26
EDAT- 2009/08/12 09:00
MHDA- 2010/04/13 06:00
CRDT- 2009/08/12 09:00
PHST- 2009/08/12 09:00 [entrez]
PHST- 2009/08/12 09:00 [pubmed]
PHST- 2010/04/13 06:00 [medline]
AID - S1041610209990706 [pii]
AID - 10.1017/S1041610209990706 [doi]
PST - ppublish
SO  - Int Psychogeriatr. 2010 Mar;22(2):201-8. doi: 10.1017/S1041610209990706. Epub
      2009 Aug 10.


PMID- 19664044
OWN - NLM
STAT- MEDLINE
DCOM- 20100719
LR  - 20100831
IS  - 1745-6584 (Electronic)
IS  - 0017-467X (Linking)
VI  - 48
IP  - 1
DP  - 2010 Jan-Feb
TI  - Role of ethics in groundwater management.
PG  - 1
LID - 10.1111/j.1745-6584.2009.00611.x [doi]
FAU - Liu, Jie
AU  - Liu J
FAU - Zhang, Maosheng
AU  - Zhang M
FAU - Zheng, Chunmiao
AU  - Zheng C
LA  - eng
PT  - Editorial
DEP - 20090731
PL  - United States
TA  - Ground Water
JT  - Ground water
JID - 9882886
SB  - IM
CIN - Ground Water. 2010 Jul-Aug;48(4):480-1; discussion 481. PMID: 20642628
MH  - China
MH  - Conservation of Natural Resources
MH  - Environmental Monitoring/*ethics
MH  - Fresh Water
MH  - *Water Movements
EDAT- 2009/08/12 09:00
MHDA- 2010/07/20 06:00
CRDT- 2009/08/12 09:00
PHST- 2009/08/12 09:00 [entrez]
PHST- 2009/08/12 09:00 [pubmed]
PHST- 2010/07/20 06:00 [medline]
AID - GWAT611 [pii]
AID - 10.1111/j.1745-6584.2009.00611.x [doi]
PST - ppublish
SO  - Ground Water. 2010 Jan-Feb;48(1):1. doi: 10.1111/j.1745-6584.2009.00611.x. Epub
      2009 Jul 31.


PMID- 19662329
OWN - NLM
STAT- MEDLINE
DCOM- 20100826
LR  - 20211020
IS  - 1248-9204 (Electronic)
IS  - 1248-9204 (Linking)
VI  - 14
IP  - 3
DP  - 2010 Jun
TI  - Single-port access in laparoscopic bilateral inguinal hernia repair: first
      clinical report of a novel technique.
PG  - 309-12
LID - 10.1007/s10029-009-0534-x [doi]
AB  - PURPOSE: To report the initial clinical case of single-port transabdominal
      preperitoneal (TAPP) bilateral inguinal hernia repair. METHODS: One patient with 
      symptomatic bilateral inguinal hernias underwent a single-port TAPP hernia repair
      using the Triport Single Port System (ASC, TriPort Laparoscopic Access Device,
      Wicklow, Ireland). The device was placed through a single supraumbilical
      incision. Hernia repair was performed with a typical TAPP technique with
      implantation of an Ultrapro Mesh (Ethicon, Norderstedt, Germany). RESULTS: The
      procedure was technically successful without placement of additional trocars.
      Operative time was 120 min. No blood loss and no intraoperative complications
      were observed. The patient was discharged on the 2nd postoperative day and
      follow-up at 2 weeks demonstrated the patient to be without complaints with
      uncomplicated wound healing. CONCLUSION: Single-port TAPP bilateral inguinal
      hernia repair is technically feasible and safe.
FAU - Menenakos, C
AU  - Menenakos C
AD  - Department of General, Visceral, Vascular and Thoracic Surgery, Charite,
      Universitaetsmedizin Berlin, Campus Mitte, Chariteplatz 1, 10117, Berlin,
      Germany. charalambos.menenakos@charite.de
FAU - Kilian, M
AU  - Kilian M
FAU - Hartmann, J
AU  - Hartmann J
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20090807
PL  - France
TA  - Hernia
JT  - Hernia : the journal of hernias and abdominal wall surgery
JID - 9715168
SB  - IM
MH  - Adult
MH  - Hernia, Inguinal/*surgery
MH  - Humans
MH  - Laparoscopy/methods
MH  - Male
EDAT- 2009/08/08 09:00
MHDA- 2010/08/27 06:00
CRDT- 2009/08/08 09:00
PHST- 2009/03/30 00:00 [received]
PHST- 2009/07/10 00:00 [accepted]
PHST- 2009/08/08 09:00 [entrez]
PHST- 2009/08/08 09:00 [pubmed]
PHST- 2010/08/27 06:00 [medline]
AID - 10.1007/s10029-009-0534-x [doi]
PST - ppublish
SO  - Hernia. 2010 Jun;14(3):309-12. doi: 10.1007/s10029-009-0534-x. Epub 2009 Aug 7.


PMID- 19660843
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20151119
IS  - 1532-2793 (Electronic)
IS  - 0260-6917 (Linking)
VI  - 30
IP  - 2
DP  - 2010 Feb
TI  - Nurse educators' teaching of codes of ethics.
PG  - 124-31
LID - 10.1016/j.nedt.2009.06.011 [doi]
AB  - Although codes of ethics are thought to be an important element of nursing ethics
      curriculum research focusing on nurses' codes is scarce and negligible in the
      area of education. This study explores Finnish nurse educators' teaching of codes
      of ethics. A total of 183 nurse educators from polytechnics providing basic
      nursing education in Finland answered a structured questionnaire with one
      open-ended question. The data was analysed statistically by SPSS and by content
      analysis. The responding educators' teaching of the codes was rather extensive.
      The focus of teaching was on the nurse-patient relationship. Nursing in a wider
      social context was less emphasized. Integrated teaching was the prevalent
      teaching format. Educators' use of teaching and evaluation methods was fairly
      narrow aiming at a student-centred approach. Educators' knowledge of the codes
      was mainly based on informal learning. The majority assessed their knowledge as
      adequate for teaching the codes. Educators who were motivated to build their
      knowledge voluntarily also taught the codes more. Educators assessed nursing
      students' knowledge and ability to apply the codes as mediocre. Organization of
      integrated teaching, objective assessment of nurse educators' competence to teach
      the codes, and evaluation of student outcomes need further exploring.
CI  - Copyright 2009 Elsevier Ltd. All rights reserved.
FAU - Numminen, Olivia H
AU  - Numminen OH
AD  - Department of Nursing Science, University of Turku, Luotsikatu 9D 11, FI-00160
      Helsinki, Finland. j.o.numminen@welho.com
FAU - Leino-Kilpi, Helena
AU  - Leino-Kilpi H
FAU - van der Arend, Arie
AU  - van der Arend A
FAU - Katajisto, Jouko
AU  - Katajisto J
LA  - eng
PT  - Journal Article
DEP - 20090805
PL  - Scotland
TA  - Nurse Educ Today
JT  - Nurse education today
JID - 8511379
MH  - Adult
MH  - Analysis of Variance
MH  - *Codes of Ethics
MH  - *Curriculum
MH  - Education, Nursing/*ethics
MH  - Ethics, Nursing/*education
MH  - *Faculty, Nursing
MH  - Female
MH  - Finland
MH  - Humans
MH  - Learning
MH  - Male
MH  - Middle Aged
MH  - Nursing Research
MH  - Reproducibility of Results
MH  - Statistics as Topic
MH  - Students, Nursing
MH  - Surveys and Questionnaires
MH  - *Teaching
EDAT- 2009/08/08 09:00
MHDA- 2011/01/07 06:00
CRDT- 2009/08/08 09:00
PHST- 2009/01/03 00:00 [received]
PHST- 2009/06/11 00:00 [revised]
PHST- 2009/06/19 00:00 [accepted]
PHST- 2009/08/08 09:00 [entrez]
PHST- 2009/08/08 09:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
AID - S0260-6917(09)00129-4 [pii]
AID - 10.1016/j.nedt.2009.06.011 [doi]
PST - ppublish
SO  - Nurse Educ Today. 2010 Feb;30(2):124-31. doi: 10.1016/j.nedt.2009.06.011. Epub
      2009 Aug 5.


PMID- 19659752
OWN - NLM
STAT- MEDLINE
DCOM- 20100818
LR  - 20151119
IS  - 1468-1331 (Electronic)
IS  - 1351-5101 (Linking)
VI  - 17
IP  - 1
DP  - 2010 Jan
TI  - Use of cerebrospinal fluid biomarkers in diagnosis of dementia across Europe.
PG  - 90-6
LID - 10.1111/j.1468-1331.2009.02753.x [doi]
AB  - BACKGROUND AND PURPOSE: Cerebrospinal fluid (CSF) biomarkers have been reported
      to be useful in dementia diagnosis. Not much is known about their use in clinical
      practice in Europe. METHODS: We analyzed data from a survey on the use of CSF
      biomarkers in the diagnosis of dementia across Europe using a questionnaire which
      was filled out by representatives of the 25 member countries of the European
      Federation of Neurological Societies (EFNS). RESULTS: Cerebrospinal fluid
      beta-amyloid, total tau, and phosphorylated tau proteins are frequently evaluated
      in the majority of the countries (in 18 out of 23 countries). No major technical 
      or ethical issues were found that would hamper the procedure's ability to become 
      routine in early and differential diagnostics of Alzheimer's disease. Cut-off
      values for beta-amyloid (median 500, range 300-849 pg/ml), total tau (367;
      195-450 pg/ml) and phosphorylated tau (60; 40-85 pg/ml) varied considerably
      amongst countries and even within every country. CONCLUSIONS: Cerebrospinal fluid
      analysis of beta-amyloid, tau, and phosphorylated tau is frequently used in
      Europe. However, the use of various cut off values seriously hampers
      comparability and yields a potential threat to an interpretation and balanced use
      in clinical practice. We recommend that each laboratory establishes normative
      data and that multi-centered studies should be organized to explore the reasons
      for any differences.
FAU - Hort, J
AU  - Hort J
AD  - Department of Neurology, Memory Disorders Clinic, Charles University in Prague,
      Second Faculty of Medicinel, University Hospital Motol, Prague, Czech Republic.
      jakub.hort@seznam.cz
FAU - Bartos, A
AU  - Bartos A
FAU - Pirttila, T
AU  - Pirttila T
FAU - Scheltens, P
AU  - Scheltens P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090729
PL  - England
TA  - Eur J Neurol
JT  - European journal of neurology
JID - 9506311
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Biomarkers)
RN  - 0 (tau Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Amyloid beta-Peptides/analysis/*cerebrospinal fluid
MH  - Biomarkers/analysis/cerebrospinal fluid
MH  - Brain/metabolism/physiopathology
MH  - Dementia/*cerebrospinal fluid/*diagnosis/physiopathology
MH  - Europe
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Phosphorylation
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Sensitivity and Specificity
MH  - Young Adult
MH  - tau Proteins/analysis/*cerebrospinal fluid
EDAT- 2009/08/08 09:00
MHDA- 2010/08/19 06:00
CRDT- 2009/08/08 09:00
PHST- 2009/08/08 09:00 [entrez]
PHST- 2009/08/08 09:00 [pubmed]
PHST- 2010/08/19 06:00 [medline]
AID - ENE2753 [pii]
AID - 10.1111/j.1468-1331.2009.02753.x [doi]
PST - ppublish
SO  - Eur J Neurol. 2010 Jan;17(1):90-6. doi: 10.1111/j.1468-1331.2009.02753.x. Epub
      2009 Jul 29.


PMID- 19658038
OWN - NLM
STAT- MEDLINE
DCOM- 20100513
LR  - 20171116
IS  - 1476-4954 (Electronic)
IS  - 1476-4954 (Linking)
VI  - 23
IP  - 2
DP  - 2010 Feb
TI  - Ethical issue and consent form in the management of high-risk pregnancy.
PG  - 179-83
LID - 10.3109/14767050903165206 [doi]
AB  - Through the description of two high risk unplanned pregnancy cases and the
      subsequent interview of the patients, a few years after delivery, this article
      focuses on the following issues: 1. The importance of a planned pregnancy in a
      woman with diabetes or other chronic disease; 2. The ethical role of counselling 
      and how it should not be influenced by the ethical belief of the obstetrician; 3.
      The legal aspect related to the knowledge and qualifications of the obstetrician 
      in the management of a high-risk pregnancy to improve both maternal and fetal
      outcomes. Here, two cases of complicated type 1 diabetes in women with unplanned 
      pregnancies and the importance of counselling in high-risk pregnancy are
      presented.
FAU - Riviello, Chiara
AU  - Riviello C
AD  - Department of Gynaecology, Perinatology and Human Reproduction, University of
      Florence, Florence, Italy. chiarariviello@libero.it
FAU - Ottanelli, Serena
AU  - Ottanelli S
FAU - Di Tommaso, Maria Rosaria
AU  - Di Tommaso MR
FAU - Mello, Giorgio
AU  - Mello G
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - J Matern Fetal Neonatal Med
JT  - The journal of maternal-fetal & neonatal medicine : the official journal of the
      European Association of Perinatal Medicine, the Federation of Asia and Oceania
      Perinatal Societies, the International Society of Perinatal Obstetricians
JID - 101136916
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Adult
MH  - *Bioethical Issues
MH  - Blindness/complications
MH  - Blood Glucose/analysis
MH  - Chronic Disease
MH  - Clinical Competence/legislation & jurisprudence
MH  - Counseling
MH  - Diabetic Foot/complications
MH  - Diabetic Neuropathies/complications
MH  - Diabetic Retinopathy/complications
MH  - Female
MH  - Glycated Hemoglobin A/analysis
MH  - Humans
MH  - Infant, Newborn
MH  - Informed Consent
MH  - Male
MH  - Obstetrics/ethics/legislation & jurisprudence
MH  - Pregnancy
MH  - Pregnancy Complications/*therapy
MH  - Pregnancy Outcome
MH  - Pregnancy in Diabetics/therapy
MH  - *Pregnancy, High-Risk
MH  - Twins
EDAT- 2009/08/07 09:00
MHDA- 2010/05/14 06:00
CRDT- 2009/08/07 09:00
PHST- 2009/08/07 09:00 [entrez]
PHST- 2009/08/07 09:00 [pubmed]
PHST- 2010/05/14 06:00 [medline]
AID - 913568128 [pii]
AID - 10.3109/14767050903165206 [doi]
PST - ppublish
SO  - J Matern Fetal Neonatal Med. 2010 Feb;23(2):179-83. doi:
      10.3109/14767050903165206.


PMID- 19657739
OWN - NLM
STAT- MEDLINE
DCOM- 20100315
LR  - 20211020
IS  - 1557-1920 (Electronic)
IS  - 1557-1912 (Linking)
VI  - 12
IP  - 1
DP  - 2010 Feb
TI  - Undocumented migrants in Canada: a scope literature review on health, access to
      services, and working conditions.
PG  - 132-51
LID - 10.1007/s10903-009-9280-5 [doi]
AB  - It is estimated that there are 30-40 million undocumented workers worldwide.
      Although undocumented migration has become an issue of high international
      relevance, it has been strikingly understudied in Canada, especially with respect
      to its impact on health. The purpose of this study is to explore the concept of
      undocumentedness in Canada through a scoping review of peer-reviewed and grey
      literature written in English, French, Portuguese and Spanish between 2002 and
      2008. The specific aims are to: (i) summarize and disseminate current academic
      and community-based findings on the health, service access and working conditions
      of undocumented migrants in Canada; (ii) examine the sources and use of evidence;
      (iii) identify significant gaps in existing knowledge; (iv) set recommendations
      for policy and research, including considerations on transnationalism, ethics,
      interdisciplinary approaches, gender differences, resilience, and impact on the
      children of non-status parents.
FAU - Magalhaes, Lilian
AU  - Magalhaes L
AD  - School of Occupational Therapy, University of Western Ontario, 1201 Western Road,
      Elborn College, London, ON N6G 1H1, Canada. lmagalha@uwo.ca
FAU - Carrasco, Christine
AU  - Carrasco C
FAU - Gastaldo, Denise
AU  - Gastaldo D
LA  - eng
GR  - 85038/CAPMC/ CIHR/Canada
GR  - 93744/CAPMC/ CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - J Immigr Minor Health
JT  - Journal of immigrant and minority health
JID - 101256527
SB  - IM
MH  - Canada
MH  - Emigration and Immigration/*legislation & jurisprudence
MH  - Female
MH  - *Health Services Accessibility
MH  - *Health Status
MH  - Humans
MH  - Male
MH  - *Occupational Exposure
MH  - Social Justice
MH  - *Transients and Migrants
RF  - 45
PMC - PMC3084189
MID - CAMS861
OID - NLM: CAMS861
EDAT- 2009/08/07 09:00
MHDA- 2010/03/17 06:00
CRDT- 2009/08/07 09:00
PHST- 2009/08/07 09:00 [entrez]
PHST- 2009/08/07 09:00 [pubmed]
PHST- 2010/03/17 06:00 [medline]
AID - 10.1007/s10903-009-9280-5 [doi]
PST - ppublish
SO  - J Immigr Minor Health. 2010 Feb;12(1):132-51. doi: 10.1007/s10903-009-9280-5.


PMID- 19657646
OWN - NLM
STAT- MEDLINE
DCOM- 20100330
LR  - 20211020
IS  - 1432-1084 (Electronic)
IS  - 0938-7994 (Linking)
VI  - 20
IP  - 1
DP  - 2010 Jan
TI  - Long-term results of percutaneous resection and interstitial laser ablation of
      osteoid osteomas.
PG  - 209-17
LID - 10.1007/s00330-009-1537-9 [doi]
AB  - To evaluate the efficiency and complication rate of two percutaneous treatments
      of osteoid osteomas, percutaneous trephine resection (PR) and interstitial laser 
      ablation (ILA). Ethical review board was obtained for the retrospective study.
      One hundred and 26 patients were treated by PR (n = 26) or ILA (n = 100) under
      CT, with a median follow-up of 113 months for the PR group and 47 months for the 
      ILA group. In the group treated by PR, the clinical success rate was 96% at
      6-month and 95% at 24-month follow-up, with 12% (3/26) transient complications
      (one meralgia, two skin burns). One patient experienced immediate failure, and
      none had delayed failure. In the group treated by ILA, the clinical success rate 
      was 96% at 6-month and 94% at 24-month follow-up, with 4% (4/100) transient
      complications (one common fibular nerve contusion, one hematoma, one infection
      and one tendinitis). Four ILA procedures were repeated, one because of initial
      failure and three because of recurrence (at 6.5, 15 and 32 months). Two were
      successful and two failed again. Failure was more frequent (p = 0.0094) in
      patients less than 18 years old, and in lesions with a nidus size of 12 mm or
      larger (p = 0.0022).
FAU - Roqueplan, Francois
AU  - Roqueplan F
AD  - Service de Radiologie Osteo-articulaire, Hopital Lariboisiere, Assistance
      Publique-Hopitaux de Paris, 2 rue Ambroise Pare, 75475 Paris Cedex 10, France.
FAU - Porcher, Raphael
AU  - Porcher R
FAU - Hamze, Bassam
AU  - Hamze B
FAU - Bousson, Valerie
AU  - Bousson V
FAU - Zouari, Leila
AU  - Zouari L
FAU - Younan, Tonine
AU  - Younan T
FAU - Parlier-Cuau, Caroline
AU  - Parlier-Cuau C
FAU - Laredo, Jean-Denis
AU  - Laredo JD
LA  - eng
PT  - Journal Article
DEP - 20090806
PL  - Germany
TA  - Eur Radiol
JT  - European radiology
JID - 9114774
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Bone Neoplasms/diagnostic imaging/*surgery
MH  - Child
MH  - Female
MH  - Humans
MH  - *Laser Therapy
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/diagnostic imaging/*surgery
MH  - Osteoma, Osteoid/diagnostic imaging/*surgery
MH  - Retrospective Studies
MH  - Tomography, X-Ray Computed
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2009/08/07 09:00
MHDA- 2010/03/31 06:00
CRDT- 2009/08/07 09:00
PHST- 2009/01/05 00:00 [received]
PHST- 2009/06/23 00:00 [accepted]
PHST- 2009/06/13 00:00 [revised]
PHST- 2009/08/07 09:00 [entrez]
PHST- 2009/08/07 09:00 [pubmed]
PHST- 2010/03/31 06:00 [medline]
AID - 10.1007/s00330-009-1537-9 [doi]
PST - ppublish
SO  - Eur Radiol. 2010 Jan;20(1):209-17. doi: 10.1007/s00330-009-1537-9. Epub 2009 Aug 
      6.


PMID- 19645704
OWN - NLM
STAT- MEDLINE
DCOM- 20101008
LR  - 20211020
IS  - 1541-0420 (Electronic)
IS  - 0006-341X (Linking)
VI  - 66
IP  - 2
DP  - 2010 Jun
TI  - Hierarchical and joint site-edge methods for medicare hospice service region
      boundary analysis.
PG  - 355-64
LID - 10.1111/j.1541-0420.2009.01291.x [doi]
AB  - Hospice service offers a convenient and ethically preferable health-care option
      for terminally ill patients. However, this option is unavailable to patients in
      remote areas not served by any hospice system. In this article, we seek to
      determine the service areas of two particular cancer hospice systems in
      northeastern Minnesota based only on death counts abstracted from Medicare
      billing records. The problem is one of spatial boundary analysis, a field that
      appears statistically underdeveloped for irregular areal (lattice) data, even
      though most publicly available human health data are of this type. In this
      article, we suggest a variety of hierarchical models for areal boundary analysis 
      that hierarchically or jointly parameterize both the areas and the edge segments.
      This leads to conceptually appealing solutions for our data that remain
      computationally feasible. While our approaches parallel similar developments in
      statistical image restoration using Markov random fields, important differences
      arise due to the irregular nature of our lattices, the sparseness and high
      variability of our data, the existence of important covariate information, and
      most importantly, our desire for full posterior inference on the boundary. Our
      results successfully delineate service areas for our two Minnesota hospice
      systems that sometimes conflict with the hospices' self-reported service areas.
      We also obtain boundaries for the spatial residuals from our fits, separating
      regions that differ for reasons yet unaccounted for by our model.
FAU - Ma, Haijun
AU  - Ma H
AD  - MMC 303, School of Public Health, University of Minnesota, Minneapolis, Minnesota
      55455-0392, USA.
FAU - Carlin, Bradley P
AU  - Carlin BP
FAU - Banerjee, Sudipto
AU  - Banerjee S
LA  - eng
GR  - R01 CA095955/CA/NCI NIH HHS/United States
GR  - R01 CA112444-03/CA/NCI NIH HHS/United States
GR  - 1-R01-CA112444-03/CA/NCI NIH HHS/United States
GR  - R01 CA095955-05A2/CA/NCI NIH HHS/United States
GR  - R01 CA112444/CA/NCI NIH HHS/United States
GR  - 1-R01-CA95955-01/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20090723
PL  - United States
TA  - Biometrics
JT  - Biometrics
JID - 0370625
SB  - IM
MH  - Health Services Accessibility/*statistics & numerical data
MH  - Hospice Care/*statistics & numerical data
MH  - Hospices
MH  - Humans
MH  - Medicare
MH  - Methods
MH  - Minnesota
MH  - *Models, Statistical
MH  - Mortality
MH  - Neoplasms/therapy
MH  - United States
PMC - PMC3061258
MID - NIHMS138781
EDAT- 2009/08/04 09:00
MHDA- 2010/10/12 06:00
CRDT- 2009/08/04 09:00
PHST- 2009/08/04 09:00 [entrez]
PHST- 2009/08/04 09:00 [pubmed]
PHST- 2010/10/12 06:00 [medline]
AID - BIOM1291 [pii]
AID - 10.1111/j.1541-0420.2009.01291.x [doi]
PST - ppublish
SO  - Biometrics. 2010 Jun;66(2):355-64. doi: 10.1111/j.1541-0420.2009.01291.x. Epub
      2009 Jul 23.


PMID- 19644791
OWN - NLM
STAT- MEDLINE
DCOM- 20100406
LR  - 20100122
IS  - 1098-8785 (Electronic)
IS  - 0735-1631 (Linking)
VI  - 27
IP  - 2
DP  - 2010 Feb
TI  - Two cases of pontocerebellar hypoplasia: ethical and prenatal diagnostic dilemma.
PG  - 181-7
LID - 10.1055/s-0029-1234030 [doi]
AB  - We report the clinical characteristics and the outcome of two cases of
      pontocerebellar hypoplasia (PCH) in one family. The objective of this report is
      to describe the mode of presentation, discuss the clinical course, and address
      the dilemma of prenatal diagnosis and the prospects for genetic diagnosis for
      PCH. The first case is a 4-year-old boy in whom the diagnosis was made in the
      neonatal period. Despite extensive prenatal follow-up during the mother's
      subsequent pregnancy, prenatal diagnosis could not be made and a second affected 
      child was born. Both siblings have severe developmental delay. The cases raise an
      important ethical dilemma about the most appropriate intervention if the mother
      of a child affected with PCH becomes pregnant. PCH is considered to have an
      autosomal-recessive mode of inheritance and a recurrence risk of 25% in each
      pregnancy. Until recently when genetic mutations in PCH types 2, 4, and 6 began
      to be identified, the lack of well-recognized genetic testing precluded experts
      from making clear recommendations. The best advice to these parents was difficult
      or elusive. With two children currently affected, should the parents terminate or
      continue with the latest pregnancy? Extensive monitoring with serial prenatal
      ultrasound failed in the previous pregnancy and resulted in the birth of the
      second affected child. It is evident that serial ultrasound scan may not be
      helpful in making the diagnosis prenatally. Therefore, other diagnostic
      modalities such as magnetic resonance imaging may be necessary and should be
      considered. With the identification of genetic basis or mutations in PCH types 2,
      4, and 6 and possible development of commercial genetic testing for these types
      of PCH, reproductive decision or genetic testing during pregnancy should be
      recommended to affected families to enable informed choices.
CI  - Thieme Medical Publishers.
FAU - Ajibola, Ayodeji J
AU  - Ajibola AJ
AD  - Division of Neonatology, Department of Pediatrics and Human Development, College 
      of Human Medicine, Michigan State University, East Lansing, MI 48912, USA.
FAU - Netzloff, Michael
AU  - Netzloff M
FAU - Samaraweera, Ranji
AU  - Samaraweera R
FAU - Omar, Said A
AU  - Omar SA
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20090730
PL  - United States
TA  - Am J Perinatol
JT  - American journal of perinatology
JID - 8405212
SB  - IM
MH  - Adult
MH  - Brain/pathology
MH  - Cerebellum/abnormalities
MH  - Child, Preschool
MH  - Congenital Abnormalities/genetics
MH  - Consanguinity
MH  - *Decision Making
MH  - Developmental Disabilities/etiology
MH  - *Ethics, Medical
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Mutation
MH  - Pons/*abnormalities
MH  - Pregnancy
MH  - Siblings
MH  - Ultrasonography, Prenatal
EDAT- 2009/08/01 09:00
MHDA- 2010/04/07 06:00
CRDT- 2009/08/01 09:00
PHST- 2009/08/01 09:00 [entrez]
PHST- 2009/08/01 09:00 [pubmed]
PHST- 2010/04/07 06:00 [medline]
AID - 10.1055/s-0029-1234030 [doi]
PST - ppublish
SO  - Am J Perinatol. 2010 Feb;27(2):181-7. doi: 10.1055/s-0029-1234030. Epub 2009 Jul 
      30.


PMID- 19644771
OWN - NLM
STAT- MEDLINE
DCOM- 20100923
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 16
IP  - 2
DP  - 2010 Jun
TI  - Toward an horizon in design ethics.
PG  - 355-70
LID - 10.1007/s11948-009-9157-y [doi]
AB  - This paper suggests that design ethics can be enriched by considering ethics
      beyond the traditional approaches of deontology, teleology, and virtue ethics.
      Design practice and design ethics literature tend to frame ethics in design
      according to these approaches. The paper argues that a fundamental and concrete
      ethical understanding of design ethics can also be found in Sartrean
      Existentialism, a philosophy centered on the individual and his/her absolute
      freedom. Through the analysis of four core concepts of Sartrean Existentialism
      that define a specific ethics, the paper illustrates why such philosophical
      approach is relevant to design ethics. The paper also shows how Sartrean
      Existentialism and its ethics apply to critical issues of professional practice
      in design such as professional engagement and design decision-making. The paper
      finally argues that Sartre's philosophy and ethics is a perspective that offers
      the designer in design practice a solid ground to engage his/her ethical dilemma.
FAU - d'Anjou, Philippe
AU  - d'Anjou P
AD  - Florida Atlantic University, 111 East Las Olas Boulevard, Fort Lauderdale, FL
      33301, USA. pdanjou@fau.edu
LA  - eng
PT  - Biography
PT  - Historical Article
PT  - Journal Article
DEP - 20090731
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Architecture/ethics/history
MH  - Codes of Ethics/*history
MH  - Engineering/ethics/history
MH  - Ethical Relativism/history
MH  - Ethical Theory/*history
MH  - Existentialism/*history
MH  - History, 20th Century
MH  - Humans
MH  - *Professional Competence
PS  - Sartre J
FPS - Sartre, Jean-Paul
EDAT- 2009/08/01 09:00
MHDA- 2010/09/24 06:00
CRDT- 2009/08/01 09:00
PHST- 2009/04/12 00:00 [received]
PHST- 2009/07/21 00:00 [accepted]
PHST- 2009/08/01 09:00 [entrez]
PHST- 2009/08/01 09:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
AID - 10.1007/s11948-009-9157-y [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2010 Jun;16(2):355-70. doi: 10.1007/s11948-009-9157-y. Epub 2009 
      Jul 31.


PMID- 19644770
OWN - NLM
STAT- MEDLINE
DCOM- 20100701
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 16
IP  - 1
DP  - 2010 Mar
TI  - On genies and bottles: scientists' moral responsibility and dangerous technology 
      R&D.
PG  - 119-33
LID - 10.1007/s11948-009-9158-x [doi]
AB  - The age-old maxim of scientists whose work has resulted in deadly or dangerous
      technologies is: scientists are not to blame, but rather technologists and
      politicians must be morally culpable for the uses of science. As new technologies
      threaten not just populations but species and biospheres, scientists should
      reassess their moral culpability when researching fields whose impact may be
      catastrophic. Looking at real-world examples such as smallpox research and the
      Australian "mousepox trick", and considering fictional or future technologies
      like Kurt Vonnegut's "ice-nine" from Cat's Cradle, and the "grey goo" scenario in
      nanotechnology, this paper suggests how ethical principles developed in
      biomedicine can be adjusted for science in general. An "extended moral horizon"
      may require looking not just to the effects of research on individual human
      subjects, but also to effects on humanity as a whole. Moreover, a crude
      utilitarian calculus can help scientists make moral decisions about which
      technologies to pursue and disseminate when catastrophes may result. Finally,
      institutions should be devised to teach these moral principles to scientists, and
      require moral education for future funding.
FAU - Koepsell, David
AU  - Koepsell D
AD  - Department of Philosophy, Faculty of Technology, Policy, and Management, Delft
      University of Technology, 2600 GA Delft, The Netherlands. d.r.koepsell@tudelft.nl
LA  - eng
PT  - Journal Article
DEP - 20090731
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Bioethics
MH  - Biomedical Research/*ethics
MH  - Bioterrorism/ethics/prevention & control
MH  - Codes of Ethics
MH  - Decision Making/ethics
MH  - *Double Effect Principle
MH  - Ethical Theory
MH  - Forecasting
MH  - Genetic Engineering/ethics
MH  - Guidelines as Topic
MH  - Humans
MH  - Information Dissemination/ethics
MH  - *Moral Obligations
MH  - Principle-Based Ethics
MH  - *Professional Role
MH  - Research Support as Topic/ethics
MH  - Risk Assessment/ethics
MH  - Science/*ethics
MH  - Variola virus/genetics
PMC - PMC2832882
EDAT- 2009/08/01 09:00
MHDA- 2010/07/02 06:00
CRDT- 2009/08/01 09:00
PHST- 2009/02/12 00:00 [received]
PHST- 2009/07/21 00:00 [accepted]
PHST- 2009/08/01 09:00 [entrez]
PHST- 2009/08/01 09:00 [pubmed]
PHST- 2010/07/02 06:00 [medline]
AID - 10.1007/s11948-009-9158-x [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2010 Mar;16(1):119-33. doi: 10.1007/s11948-009-9158-x. Epub 2009 
      Jul 31.


PMID- 19644768
OWN - NLM
STAT- MEDLINE
DCOM- 20100603
LR  - 20211020
IS  - 1573-7292 (Electronic)
IS  - 1389-9600 (Linking)
VI  - 9
IP  - 1
DP  - 2010 Mar
TI  - A clinical perspective on ethical arguments around prenatal diagnosis and
      preimplantation genetic diagnosis for later onset inherited cancer
      predispositions.
PG  - 9-14
LID - 10.1007/s10689-009-9271-7 [doi]
AB  - Prenatal diagnosis (PND) and preimplantation genetic diagnosis (PGD) for later
      onset and/or reduced penetrance inherited cancer predispositions, e.g. familial
      adenomatous polyposis, hereditary non-polyposis colorectal cancer/Lynch syndrome 
      and hereditary breast and ovarian cancer, raise a number of ethical issues. Some 
      of these are the same as for conditions which present early in childhood, are
      fully penetrant and for which no/limited treatment options are possible; others
      relate to whether reduced penetrance and/or the availability of treatment mean
      that these are not serious (enough) conditions to warrant tests prior to/during
      pregnancy or to justify termination of pregnancy. However, attempts to reach a
      consensus on what counts as a serious (enough) condition in the context of PND
      and PGD have been unsuccessful. Such a definition may anyway be unhelpful if it
      cannot also take into account, for example, the woman's/couple's awareness and
      experience of the condition and the impact of the condition on affected
      individuals and their families. Individuals affected by, or at high risk of,
      later onset and/or reduced penetrance inherited cancer predispositions are
      generally supportive of access to PND and PGD for their own conditions, even if
      they would not consider using it themselves. Professionals working in clinical
      cancer genetics need to be prepared to discuss PND and PGD with this group of
      patients.
FAU - Clancy, Tara
AU  - Clancy T
AD  - Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester 
      University Hospitals NHS Foundation Trust, St Mary's Hospital, Oxford Road,
      Manchester, M13 9WL, UK. tara.clancy@cmft.nhs.uk
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090731
PL  - Netherlands
TA  - Fam Cancer
JT  - Familial cancer
JID - 100898211
SB  - IM
MH  - Attitude to Health/ethnology
MH  - *Family Characteristics
MH  - Female
MH  - Genes, BRCA1/*physiology
MH  - Genetic Predisposition to Disease/*genetics
MH  - Humans
MH  - Ovarian Neoplasms/*diagnosis/epidemiology/genetics
MH  - Pregnancy
MH  - Preimplantation Diagnosis/ethics/*methods
MH  - Prenatal Diagnosis/ethics/*methods
MH  - Risk Assessment/methods
MH  - *Surveys and Questionnaires
EDAT- 2009/08/01 09:00
MHDA- 2010/06/04 06:00
CRDT- 2009/08/01 09:00
PHST- 2009/03/05 00:00 [received]
PHST- 2009/07/16 00:00 [accepted]
PHST- 2009/08/01 09:00 [entrez]
PHST- 2009/08/01 09:00 [pubmed]
PHST- 2010/06/04 06:00 [medline]
AID - 10.1007/s10689-009-9271-7 [doi]
PST - ppublish
SO  - Fam Cancer. 2010 Mar;9(1):9-14. doi: 10.1007/s10689-009-9271-7. Epub 2009 Jul 31.


PMID- 19637377
OWN - NLM
STAT- MEDLINE
DCOM- 20100616
LR  - 20151119
IS  - 1520-6777 (Electronic)
IS  - 0733-2467 (Linking)
VI  - 29
IP  - 3
DP  - 2010 Mar
TI  - Proof of principle: The effect of antimuscarinics on bladder filling sensations
      in healthy subjects--a placebo controlled double blind investigation using 4 and 
      8 mg tolterodine extended release.
PG  - 464-9
LID - 10.1002/nau.20743 [doi]
AB  - AIMS: There is evidence that antimuscarinic drugs have depressant influence not
      only on bladder muscle activity, but also on bladder sensations. The aim of this 
      study was to evaluate the effect of a single dose tolterodine extended release
      (ER) 4 and 8 mg on bladder sensations during filling cystometry. METHODS: After
      approval of the local ethics committee, 30 healthy female subjects (23.7 +/- 2.3 
      years) were included and randomly assigned to three groups: (A) placebo, (B)
      tolterodine ER 4 mg, and (C) tolterodine ER 8 mg in a double blind manner.
      Measurements were performed at baseline and 4 hr postmedication in each group,
      consisting of: (1) Filling cystometry with 25 ml/min at which subjects had to
      indicate first sensation of filling (FSF), first desire to void (FDV), and strong
      desire to void (SDV). (2) Uroflowmetry and ultrasound control for residual urine.
      RESULTS: In the placebo group, filling volumes at FDV and SDV decreased
      significantly posttreatment. This effect could not be observed for the
      tolterodine 8 mg group and only at SDV in the 4 mg group. No significant
      difference between groups was found regarding uroflowmetry parameters and
      postvoid residual volume. CONCLUSIONS: No increase of filling volumes in healthy 
      subjects could be observed with tolterodine. However, the results suggest that
      tolterodine is able to alleviate irritation caused by repeated catheterization
      and cystometry. There was no significant influence of tolterodine ER 4 or 8 mg on
      voiding function.
CI  - (c) 2009 Wiley-Liss, Inc.
FAU - Mehnert, Ulrich
AU  - Mehnert U
AD  - Neurourology, Spinal Cord Injury Center, Balgrist University Hospital, Zurich,
      Switzerland. ulrich.mehnert@paralab.balgrist.ch
FAU - Reitz, Andre
AU  - Reitz A
FAU - Youssef, Sumaya Abo
AU  - Youssef SA
FAU - Schurch, Brigitte
AU  - Schurch B
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neurourol Urodyn
JT  - Neurourology and urodynamics
JID - 8303326
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Cresols)
RN  - 0 (Muscarinic Antagonists)
RN  - 33RU150WUN (Phenylpropanolamine)
RN  - 5T619TQR3R (Tolterodine Tartrate)
SB  - IM
MH  - Benzhydryl Compounds/*administration & dosage
MH  - Cresols/*administration & dosage
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Muscarinic Antagonists/*administration & dosage
MH  - Phenylpropanolamine/*administration & dosage
MH  - Prospective Studies
MH  - Reference Values
MH  - Sensation/*drug effects
MH  - Tolterodine Tartrate
MH  - Urinary Bladder/*drug effects/*physiology
MH  - Young Adult
EDAT- 2009/07/29 09:00
MHDA- 2010/06/17 06:00
CRDT- 2009/07/29 09:00
PHST- 2009/07/29 09:00 [entrez]
PHST- 2009/07/29 09:00 [pubmed]
PHST- 2010/06/17 06:00 [medline]
AID - 10.1002/nau.20743 [doi]
PST - ppublish
SO  - Neurourol Urodyn. 2010 Mar;29(3):464-9. doi: 10.1002/nau.20743.


PMID- 19635009
OWN - NLM
STAT- MEDLINE
DCOM- 20100813
LR  - 20220409
IS  - 1557-8534 (Electronic)
IS  - 1547-3287 (Linking)
VI  - 19
IP  - 4
DP  - 2010 Apr
TI  - Isolation and characterization of mesenchymal stem cells from the sub-amniotic
      human umbilical cord lining membrane.
PG  - 491-502
LID - 10.1089/scd.2009.0192 [doi]
AB  - The use of human stem cells (SCs) is a promising novel approach for the treatment
      of many diseases and injuries. Umbilical cord and amniotic membrane represent
      good sources for SCs, because they are abundant sources and there are less
      ethical issues unlike embryonic SCs. We aimed to isolate and characterize adult
      SCs from the subamnion region of the umbilical cord/amniotic membrane. Because
      mesenchymal stem cells (MSCs) are thought to show less immunogenicity, we first
      focused on the characterization of MSCs. Significant expression of typical
      SC-specific markers, such as SSEA-4, Oct-4, and Nanog was observed. Subamniotic
      MSCs did not lose the expression of Oct-4 and Nanog after freeze-thawing. Cell
      surface expression of MSC markers (CD73 and CD105) was confirmed by flow
      cytometry, and cells also differentiated into adipogenic, osteogenic, and
      chondrogenic lineages. On the other hand, typical embryonic SC-specific markers
      were not expressed and the cells also did not grow in soft agar. Thus, the
      subamniotic MSCs are distinct from embryonic SCs and do not show tumorigenicity
      in vitro. The cord lining membrane (subamniotic) MSCs isolated by our method
      maintain typical characteristics of MSCs in vitro, but also showed several
      specific features.
FAU - Kita, Katsuhiro
AU  - Kita K
AD  - Department of Surgery and Shriners Hospitals for Children, The University of
      Texas Medical Branch, Galveston, Texas 77550, USA. kakita@utmb.edu
FAU - Gauglitz, Gerd G
AU  - Gauglitz GG
FAU - Phan, Thang T
AU  - Phan TT
FAU - Herndon, David N
AU  - Herndon DN
FAU - Jeschke, Marc G
AU  - Jeschke MG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Stem Cells Dev
JT  - Stem cells and development
JID - 101197107
RN  - 0 (Antigens, CD)
RN  - 0 (ENG protein, human)
RN  - 0 (Endoglin)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (NANOG protein, human)
RN  - 0 (Nanog Homeobox Protein)
RN  - 0 (Octamer Transcription Factor-3)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Stage-Specific Embryonic Antigens)
RN  - 0 (stage-specific embryonic antigen-4)
RN  - EC 3.1.3.5 (5'-Nucleotidase)
SB  - IM
MH  - 5'-Nucleotidase/genetics/metabolism
MH  - *Adipocytes/cytology/metabolism
MH  - Adult
MH  - *Adult Stem Cells/cytology/metabolism
MH  - Amnion/*cytology/metabolism
MH  - Antigens, CD/genetics/metabolism
MH  - Cell Differentiation
MH  - Cell Lineage
MH  - Cell Separation/methods
MH  - Cell Transformation, Neoplastic
MH  - *Chondrocytes/cytology/metabolism
MH  - Cryopreservation
MH  - Embryonic Stem Cells/cytology/metabolism
MH  - Endoglin
MH  - Flow Cytometry
MH  - Homeodomain Proteins/genetics/metabolism
MH  - Humans
MH  - Infant, Newborn
MH  - *Mesenchymal Stem Cells/cytology/metabolism
MH  - Nanog Homeobox Protein
MH  - Octamer Transcription Factor-3/genetics/metabolism
MH  - *Osteocytes/cytology/metabolism
MH  - Receptors, Cell Surface/genetics/metabolism
MH  - Stage-Specific Embryonic Antigens/genetics/metabolism
MH  - Umbilical Cord/*cytology/metabolism
EDAT- 2009/07/29 09:00
MHDA- 2010/08/14 06:00
CRDT- 2009/07/29 09:00
PHST- 2009/07/29 09:00 [entrez]
PHST- 2009/07/29 09:00 [pubmed]
PHST- 2010/08/14 06:00 [medline]
AID - 10.1089/scd.2009.0192 [doi]
PST - ppublish
SO  - Stem Cells Dev. 2010 Apr;19(4):491-502. doi: 10.1089/scd.2009.0192.


PMID- 19632711
OWN - NLM
STAT- MEDLINE
DCOM- 20100531
LR  - 20101118
IS  - 1879-3231 (Electronic)
IS  - 0093-691X (Linking)
VI  - 73
IP  - 6
DP  - 2010 Apr 1
TI  - Sperm storage in the vertebrate female reproductive tract: how does it work so
      well?
PG  - 713-22
LID - 10.1016/j.theriogenology.2009.07.002 [doi]
AB  - The capacity for sperm storage within the female reproductive tract occurs widely
      across all groups of vertebrate species and is exceptionally well developed in
      some reptiles (maximum duration, 7 yr) and fish (maximum duration, >1 yr).
      Amphibians (most salamanders and one species of frog; duration approximately 5
      mo), all birds examined to date and some bats, have also evolved the ability to
      store spermatozoa in the female reproductive tract. Although there are many
      reports on both the occurrence of female sperm storage and its adaptive benefits,
      few studies have been directed toward explaining the mechanisms involved.
      Phylogenetic evidence suggests that the capacity for sperm storage has evolved
      independently within different taxonomic groups, and it is by no means clear
      whether these groups have established similar or different mechanisms or whether 
      simple and common principles have been exploited during evolution. If the process
      has indeed developed by the invention of numerous different and species-specific 
      mechanisms, it is surprising that none have yet been elucidated by technologists 
      wishing to improve the long-term storage of fresh semen. On the other hand, if
      there is a simple and common solution to the problem, readily accessed by diverse
      groups of species, it is equally logical to suppose that the mechanism should be 
      easily discovered in the laboratory. While recognizing that studies on wild
      species are usually neither practically or ethically easy to undertake, it is
      clear that there is a huge and largely unexplored field to be investigated.
CI  - 2010 Elsevier Inc. All rights reserved.
FAU - Holt, W V
AU  - Holt WV
AD  - Institute of Zoology, Zoological Society of London, Regent's Park, London NW14RY,
      United Kingdom. Bill.holt@ioz.ac.uk
FAU - Lloyd, R E
AU  - Lloyd RE
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20090725
PL  - United States
TA  - Theriogenology
JT  - Theriogenology
JID - 0421510
SB  - IM
MH  - Animals
MH  - Biological Evolution
MH  - Female
MH  - *Genitalia, Female
MH  - Male
MH  - Models, Biological
MH  - Phylogeny
MH  - Research
MH  - Semen Preservation/veterinary
MH  - Species Specificity
MH  - Spermatozoa/*physiology
MH  - *Vertebrates
RF  - 87
EDAT- 2009/07/28 09:00
MHDA- 2010/06/01 06:00
CRDT- 2009/07/28 09:00
PHST- 2009/03/28 00:00 [received]
PHST- 2009/05/22 00:00 [accepted]
PHST- 2009/07/28 09:00 [entrez]
PHST- 2009/07/28 09:00 [pubmed]
PHST- 2010/06/01 06:00 [medline]
AID - S0093-691X(09)00286-6 [pii]
AID - 10.1016/j.theriogenology.2009.07.002 [doi]
PST - ppublish
SO  - Theriogenology. 2010 Apr 1;73(6):713-22. doi:
      10.1016/j.theriogenology.2009.07.002. Epub 2009 Jul 25.


PMID- 19629753
OWN - NLM
STAT- MEDLINE
DCOM- 20100923
LR  - 20100510
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 16
IP  - 2
DP  - 2010 Jun
TI  - Fair shares: a preliminary framework and case analyzing the ethics of offshoring.
PG  - 325-53
LID - 10.1007/s11948-009-9147-0 [doi]
AB  - Much has been written about the offshoring phenomenon from an economic efficiency
      perspective. Most authors have attempted to measure the net economic effects of
      the strategy and many purport to show that "in the long run" that benefits will
      outweigh the costs. There is also a relatively large literature on implementation
      which describes the best way to manage the offshoring process. But what is the
      morality of offshoring? What is its "rightness" or "wrongness?" Little analysis
      of the ethics of offshoring has been completed thus far. This paper develops a
      preliminary framework for analyzing the ethics of offshoring and then applies
      this framework to basic case study of offshoring in the U.S. The paper following 
      discusses the definition of offshoring; shifts to the basic philosophical
      grounding of the ethical concepts; develops a template for conducting an ethics
      analysis of offshoring; applies this template using basic data for offshoring in 
      the United States; and conducts a preliminary ethical analysis of the phenomenon 
      in that country, using a form of utilitarianism as an analytical baseline. The
      paper concludes with suggestions for further research.
FAU - Gordon, Cameron
AU  - Gordon C
AD  - Faculty of Business and Government, University of Canberra, Bruce, ACT 2601,
      Australia. Cameron.gordon@canberra.edu.au
FAU - Zimmerman, Alan
AU  - Zimmerman A
LA  - eng
PT  - Journal Article
DEP - 20090724
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Choice Behavior/ethics
MH  - Christianity
MH  - Cost Control/ethics
MH  - Decision Trees
MH  - Dissent and Disputes
MH  - Efficiency, Organizational/ethics
MH  - *Ethical Analysis
MH  - *Ethical Theory
MH  - *Ethics, Business
MH  - Greek World
MH  - Humans
MH  - *International Cooperation
MH  - Judgment
MH  - Outsourced Services/*ethics
MH  - Philosophy
MH  - Principle-Based Ethics
MH  - United States
MH  - Virtues
MH  - Western World
EDAT- 2009/07/25 09:00
MHDA- 2010/09/24 06:00
CRDT- 2009/07/25 09:00
PHST- 2008/11/11 00:00 [received]
PHST- 2009/06/19 00:00 [accepted]
PHST- 2009/07/25 09:00 [entrez]
PHST- 2009/07/25 09:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
AID - 10.1007/s11948-009-9147-0 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2010 Jun;16(2):325-53. doi: 10.1007/s11948-009-9147-0. Epub 2009 
      Jul 24.


PMID- 19628756
OWN - NLM
STAT- MEDLINE
DCOM- 20100323
LR  - 20091225
IS  - 1938-2707 (Electronic)
IS  - 0009-9228 (Linking)
VI  - 49
IP  - 1
DP  - 2010 Jan
TI  - Unethical prescriptions: alternative therapies for children with cerebral palsy.
PG  - 7-11
LID - 10.1177/0009922809340438 [doi]
AB  - The US National Center for Complementary and Alternative Medicine (CAM) defines
      CAM as "a group of diverse medical and health care systems, practices, and
      products that are not presently considered to be part of conventional medicine." 
      The problem with said therapies is that, for the most part, their effectiveness
      is questionable and their side effect profile is essentially unknown.
      Furthermore, as stated by Rosenbaum, many CAM treatments are based on "at best,
      anecdotal evidence and at times rather unusual ideas about the biology of the
      conditions to which they are being applied." In spite of the data
      shortage,Americans are forecasted to spend more than $42 billion on CAM during
      2009. Using a patient for illustration purposes, the author presents 3 CAM
      treatments that have been advocated for children with cerebral palsy. The current
      scientific literature on these remedies and their purported benefit is reviewed. 
      The article ends with a discussion on the reasons why prescribing said therapies 
      is contrary to the concept of evidence-based medicine and the tenets of medical
      ethics.
FAU - Weisleder, Pedro
AU  - Weisleder P
AD  - Division of Child Neurology, Nationwide Children's Hospital and The Ohio State
      University, 700 Children's Drive, Columbus, OH 43205,
      USA.pedro.weisleder@nationwidechildrens.org
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20090723
PL  - United States
TA  - Clin Pediatr (Phila)
JT  - Clinical pediatrics
JID - 0372606
SB  - IM
MH  - Animals
MH  - Cerebral Palsy/*therapy
MH  - *Complementary Therapies/economics/ethics
MH  - *Dolphins
MH  - Evidence-Based Medicine
MH  - Humans
MH  - *Hyperbaric Oxygenation
MH  - *Space Suits
RF  - 26
EDAT- 2009/07/25 09:00
MHDA- 2010/03/24 06:00
CRDT- 2009/07/25 09:00
PHST- 2009/07/25 09:00 [entrez]
PHST- 2009/07/25 09:00 [pubmed]
PHST- 2010/03/24 06:00 [medline]
AID - 0009922809340438 [pii]
AID - 10.1177/0009922809340438 [doi]
PST - ppublish
SO  - Clin Pediatr (Phila). 2010 Jan;49(1):7-11. doi: 10.1177/0009922809340438. Epub
      2009 Jul 23.


PMID- 19627427
OWN - NLM
STAT- MEDLINE
DCOM- 20100430
LR  - 20211020
IS  - 1365-2788 (Electronic)
IS  - 0964-2633 (Linking)
VI  - 54
IP  - 1
DP  - 2010 Jan 1
TI  - Overcoming the barriers experienced in conducting a medication trial in adults
      with aggressive challenging behaviour and intellectual disabilities.
PG  - 17-25
LID - 10.1111/j.1365-2788.2009.01195.x [doi]
AB  - BACKGROUND: Aggressive challenging behaviour in people with intellectual
      disability (ID) is frequently treated with antipsychotic drugs, despite a limited
      evidence base. METHOD: A multi-centre randomised controlled trial was undertaken 
      to investigate the efficacy, adverse effects and costs of two commonly prescribed
      antipsychotic drugs (risperidone and haloperidol) and placebo. RESULTS: The trial
      faced significant problems in recruitment. The intent was to recruit 120 patients
      over 2 years in three centres and to use a validated aggression scale (Modified
      Overt Aggression Scale) score as the primary outcome. Despite doubling the period
      of recruitment, only 86 patients were ultimately recruited. CONCLUSIONS:
      Variation in beliefs over the efficacy of drug treatment, difficulties within
      multidisciplinary teams and perceived ethical concerns over medication trials in 
      this population all contributed to poor recruitment. Where appropriate to the
      research question cluster randomised trials represent an ethically and
      logistically feasible alternative to individually randomised trials.
FAU - Oliver-Africano, P
AU  - Oliver-Africano P
AD  - Imperial College London, Dept. of Psychological Medicine, UK.
      p.oliver@imperial.ac.uk
FAU - Dickens, S
AU  - Dickens S
FAU - Ahmed, Z
AU  - Ahmed Z
FAU - Bouras, N
AU  - Bouras N
FAU - Cooray, S
AU  - Cooray S
FAU - Deb, S
AU  - Deb S
FAU - Knapp, M
AU  - Knapp M
FAU - Hare, M
AU  - Hare M
FAU - Meade, M
AU  - Meade M
FAU - Reece, B
AU  - Reece B
FAU - Bhaumik, S
AU  - Bhaumik S
FAU - Harley, D
AU  - Harley D
FAU - Piachaud, J
AU  - Piachaud J
FAU - Regan, A
AU  - Regan A
FAU - Ade Thomas, D
AU  - Ade Thomas D
FAU - Karatela, S
AU  - Karatela S
FAU - Rao, B
AU  - Rao B
FAU - Dzendrowskyj, T
AU  - Dzendrowskyj T
FAU - Lenotre, L
AU  - Lenotre L
FAU - Watson, J
AU  - Watson J
FAU - Tyrer, P
AU  - Tyrer P
LA  - eng
GR  - 01/07/02/DH_/Department of Health/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20090721
PL  - England
TA  - J Intellect Disabil Res
JT  - Journal of intellectual disability research : JIDR
JID - 9206090
RN  - 0 (Antipsychotic Agents)
RN  - J6292F8L3D (Haloperidol)
RN  - L6UH7ZF8HC (Risperidone)
SB  - IM
MH  - Adult
MH  - Aggression/*drug effects
MH  - Antipsychotic Agents/adverse effects/*therapeutic use
MH  - Dose-Response Relationship, Drug
MH  - Double-Blind Method
MH  - Evidence-Based Medicine
MH  - Female
MH  - Haloperidol/adverse effects/*therapeutic use
MH  - Humans
MH  - Intellectual Disability/*drug therapy/psychology
MH  - Male
MH  - *Patient Selection
MH  - Personality Assessment/statistics & numerical data
MH  - Psychometrics
MH  - Queensland
MH  - Risperidone/adverse effects/*therapeutic use
MH  - Social Behavior Disorders/*drug therapy/psychology
MH  - Treatment Outcome
MH  - United Kingdom
EDAT- 2009/07/25 09:00
MHDA- 2010/05/01 06:00
CRDT- 2009/07/25 09:00
PHST- 2009/07/25 09:00 [entrez]
PHST- 2009/07/25 09:00 [pubmed]
PHST- 2010/05/01 06:00 [medline]
AID - JIR1195 [pii]
AID - 10.1111/j.1365-2788.2009.01195.x [doi]
PST - ppublish
SO  - J Intellect Disabil Res. 2010 Jan 1;54(1):17-25. doi:
      10.1111/j.1365-2788.2009.01195.x. Epub 2009 Jul 21.


PMID- 19609725
OWN - NLM
STAT- MEDLINE
DCOM- 20100603
LR  - 20211020
IS  - 1573-7292 (Electronic)
IS  - 1389-9600 (Linking)
VI  - 9
IP  - 1
DP  - 2010 Mar
TI  - Genetic testing of children for familial cancers: a comparative legal perspective
      on consent, communication of information and confidentiality.
PG  - 75-87
LID - 10.1007/s10689-009-9268-2 [doi]
AB  - Genetic testing of children is the subject of ethical and legal debate. On the
      one hand, the literature emphasises the personal interests and rights of the
      individual child. On the other, the interests of the parents and the family as a 
      whole are discussed. English law relies by and large on a patient-centred
      approach where the child has some say about his/her medical care. The view
      reflected in Anglo-American guidelines, more specifically, is that testing is
      potentially harmful and may compromise the child's autonomy and confidentiality. 
      This explains the reluctance to submit children to predictive genetic testing. An
      analysis of Israeli law, however, reflects a different approach, where the
      benefit to the child is defined more widely. This accords with the general
      communitarian position adopted by Israeli law, a legal position that reflects the
      duality of Israeli society in simultaneously promoting both fundamental human
      rights and family ethics. In practice, however, there may be little difference,
      as children in both jurisdictions have access to similar genetic services.
FAU - Gilbar, Roy
AU  - Gilbar R
AD  - School of Law, Queen Mary College, University of London, Mile End Road, London,
      E1 4NS, UK. r.gilbar@qmul.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20090717
PL  - Netherlands
TA  - Fam Cancer
JT  - Familial cancer
JID - 100898211
SB  - IM
MH  - Access to Information/ethics
MH  - Child
MH  - Communication
MH  - Confidentiality/*legislation & jurisprudence
MH  - Family Health
MH  - Genetic Counseling/*ethics
MH  - Genetic Predisposition to Disease/genetics
MH  - Genetic Privacy/ethics/*legislation & jurisprudence
MH  - Genetic Testing/methods
MH  - Human Rights/legislation & jurisprudence
MH  - Humans
MH  - Informed Consent/*legislation & jurisprudence
MH  - Patient Rights/*legislation & jurisprudence
MH  - Truth Disclosure/ethics
EDAT- 2009/07/18 09:00
MHDA- 2010/06/04 06:00
CRDT- 2009/07/18 09:00
PHST- 2009/02/09 00:00 [received]
PHST- 2009/07/03 00:00 [accepted]
PHST- 2009/07/18 09:00 [entrez]
PHST- 2009/07/18 09:00 [pubmed]
PHST- 2010/06/04 06:00 [medline]
AID - 10.1007/s10689-009-9268-2 [doi]
PST - ppublish
SO  - Fam Cancer. 2010 Mar;9(1):75-87. doi: 10.1007/s10689-009-9268-2. Epub 2009 Jul
      17.


PMID- 19608150
OWN - NLM
STAT- MEDLINE
DCOM- 20100301
LR  - 20220317
IS  - 1097-6868 (Electronic)
IS  - 0002-9378 (Linking)
VI  - 202
IP  - 1
DP  - 2010 Jan
TI  - The perils of commercially driven surgical innovation.
PG  - 30.e1-4
LID - 10.1016/j.ajog.2009.05.031 [doi]
AB  - The practice of gynecological surgery is being reshaped by commercial interests
      that are promoting the use of trochar-and-mesh surgical kits for the treatment of
      stress incontinence and pelvic organ prolapse. In this article, we review the
      recent history of these surgical innovations and discuss the implications of
      changes in surgical practice that are driven by commercial interests of this
      kind. We situate this phenomenon within the general "life cycle" of surgical
      innovation and point out the dangers inherent in the adoption of new procedures
      without adequate evidence to support their safety and efficacy. We highlight the 
      ethical responsibilities surgeons and their professional organizations have in
      making sure such innovations are safe and effective before they come into
      widespread use. Finally, we offer some policy suggestions to ensure that this
      process has proper oversight.
CI  - 2010. Published by Mosby, Inc.
FAU - Wall, L Lewis
AU  - Wall LL
AD  - Department of Obstetrics and Gynecology and Anthropology, Washington University
      in St. Louis, MO, USA.
FAU - Brown, Douglas
AU  - Brown D
LA  - eng
PT  - Journal Article
DEP - 20090715
PL  - United States
TA  - Am J Obstet Gynecol
JT  - American journal of obstetrics and gynecology
JID - 0370476
SB  - IM
CIN - Eur Urol. 2010 Jul;58(1):179. PMID: 20825751
MH  - Commerce
MH  - *Conflict of Interest
MH  - *Ethics, Medical
MH  - Female
MH  - General Surgery/*ethics
MH  - Gynecology/*ethics
MH  - Humans
MH  - Suburethral Slings
MH  - Surgical Mesh
MH  - Therapies, Investigational
MH  - Urinary Incontinence, Stress/*surgery
MH  - Uterine Prolapse/*surgery
EDAT- 2009/07/18 09:00
MHDA- 2010/03/02 06:00
CRDT- 2009/07/18 09:00
PHST- 2009/04/23 00:00 [received]
PHST- 2009/05/14 00:00 [accepted]
PHST- 2009/07/18 09:00 [entrez]
PHST- 2009/07/18 09:00 [pubmed]
PHST- 2010/03/02 06:00 [medline]
AID - S0002-9378(09)00539-0 [pii]
AID - 10.1016/j.ajog.2009.05.031 [doi]
PST - ppublish
SO  - Am J Obstet Gynecol. 2010 Jan;202(1):30.e1-4. doi: 10.1016/j.ajog.2009.05.031.
      Epub 2009 Jul 15.


PMID- 19604289
OWN - NLM
STAT- MEDLINE
DCOM- 20110317
LR  - 20191210
IS  - 1463-1318 (Electronic)
IS  - 1462-8910 (Linking)
VI  - 12
IP  - 12
DP  - 2010 Dec
TI  - Artificial neural networks to predict presence of significant pathology in
      patients presenting to routine colorectal clinics.
PG  - 1254-9
LID - 10.1111/j.1463-1318.2009.02005.x [doi]
AB  - AIM: Artificial neural networks (ANNs) are computer programs used to identify
      complex relations within data. Routine predictions of presence of colorectal
      pathology based on population statistics have little meaning for individual
      patient. This results in large number of unnecessary lower gastrointestinal
      endoscopies (LGEs - colonoscopies and flexible sigmoidoscopies). We aimed to
      develop a neural network algorithm that can accurately predict presence of
      significant pathology in patients attending routine outpatient clinics for
      gastrointestinal symptoms. METHOD: Ethics approval was obtained and the study was
      monitored according to International Committee on Harmonisation - Good Clinical
      Practice (ICH-GCP) standards. Three-hundred patients undergoing LGE prospectively
      completed a specifically developed questionnaire, which included 40 variables
      based on clinical symptoms, signs, past- and family history. Complete data sets
      of 100 patients were used to train the ANN; the remaining data was used for
      internal validation. The primary output used was positive finding on LGE,
      including polyps, cancer, diverticular disease or colitis. For external
      validation, the ANN was applied to data from 50 patients in primary care and also
      compared with the predictions of four clinicians. RESULTS: Clear correlation
      between actual data value and ANN predictions were found (r = 0.931; P = 0.0001).
      The predictive accuracy of ANN was 95% in training group and 90% (95% CI 84-96)
      in the internal validation set and this was significantly higher than the
      clinical accuracy (75%). ANN also showed high accuracy in the external validation
      group (89%). CONCLUSION: Artificial neural networks offer the possibility of
      personal prediction of outcome for individual patients presenting in clinics with
      colorectal symptoms, making it possible to make more appropriate requests for
      lower gastrointestinal endoscopy.
CI  - (c) 2010 The Authors. Colorectal Disease (c) 2010 The Association of
      Coloproctology of Great Britain and Ireland.
FAU - Maslekar, S
AU  - Maslekar S
AD  - University of Hull and Castle Hill Hospital, Hull, UK. s.maslekar@hull.ac.uk
FAU - Gardiner, A B
AU  - Gardiner AB
FAU - Monson, J R T
AU  - Monson JR
FAU - Duthie, G S
AU  - Duthie GS
LA  - eng
PT  - Journal Article
PL  - England
TA  - Colorectal Dis
JT  - Colorectal disease : the official journal of the Association of Coloproctology of
      Great Britain and Ireland
JID - 100883611
SB  - IM
MH  - Algorithms
MH  - Colonic Diseases/*diagnosis
MH  - Colonoscopy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Neural Networks, Computer
MH  - Prospective Studies
MH  - Rectal Diseases/*diagnosis
MH  - Sigmoidoscopy
MH  - Surveys and Questionnaires
EDAT- 2009/07/17 09:00
MHDA- 2011/03/18 06:00
CRDT- 2009/07/17 09:00
PHST- 2009/07/17 09:00 [entrez]
PHST- 2009/07/17 09:00 [pubmed]
PHST- 2011/03/18 06:00 [medline]
AID - CDI2005 [pii]
AID - 10.1111/j.1463-1318.2009.02005.x [doi]
PST - ppublish
SO  - Colorectal Dis. 2010 Dec;12(12):1254-9. doi: 10.1111/j.1463-1318.2009.02005.x.


PMID- 19597969
OWN - NLM
STAT- MEDLINE
DCOM- 20100923
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 16
IP  - 2
DP  - 2010 Jun
TI  - The Engineering and Science Issues Test (ESIT): a discipline-specific approach to
      assessing moral judgment.
PG  - 387-407
LID - 10.1007/s11948-009-9148-z [doi]
AB  - To assess ethics pedagogy in science and engineering, we developed a new tool
      called the Engineering and Science Issues Test (ESIT). ESIT measures moral
      judgment in a manner similar to the Defining Issues Test, second edition, but is 
      built around technical dilemmas in science and engineering. We used a
      quasi-experimental approach with pre- and post-tests, and we compared the results
      to those of a control group with no overt ethics instruction. Our findings are
      that several (but not all) stand-alone classes showed a significant improvement
      compared to the control group when the metric includes multiple stages of moral
      development. We also found that the written test had a higher response rate and
      sensitivity to pedagogy than the electronic version. We do not find significant
      differences on pre-test scores with respect to age, education level, gender or
      political leanings, but we do on whether subjects were native English speakers.
      We did not find significant differences on pre-test scores based on whether
      subjects had previous ethics instruction; this could suggest a lack of a
      long-term effect from the instruction.
FAU - Borenstein, Jason
AU  - Borenstein J
AD  - School of Public Policy, Georgia Institute of Technology, 685 Cherry Street,
      Atlanta, GA 30332-0345, USA. borenstein@gatech.edu
FAU - Drake, Matthew J
AU  - Drake MJ
FAU - Kirkman, Robert
AU  - Kirkman R
FAU - Swann, Julie L
AU  - Swann JL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Validation Study
DEP - 20090714
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Adult
MH  - Decision Making/ethics
MH  - Educational Measurement/*methods/standards
MH  - *Engineering/education/ethics
MH  - Ethics, Professional/*education
MH  - Female
MH  - Georgia
MH  - Humans
MH  - *Judgment
MH  - Male
MH  - *Morals
MH  - Principle-Based Ethics
MH  - Problem Solving/ethics
MH  - *Science/education/ethics
MH  - Sensitivity and Specificity
EDAT- 2009/07/15 09:00
MHDA- 2010/09/24 06:00
CRDT- 2009/07/15 09:00
PHST- 2008/11/30 00:00 [received]
PHST- 2009/06/19 00:00 [accepted]
PHST- 2009/07/15 09:00 [entrez]
PHST- 2009/07/15 09:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
AID - 10.1007/s11948-009-9148-z [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2010 Jun;16(2):387-407. doi: 10.1007/s11948-009-9148-z. Epub 2009
      Jul 14.


PMID- 19597967
OWN - NLM
STAT- MEDLINE
DCOM- 20100923
LR  - 20171116
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 16
IP  - 2
DP  - 2010 Jun
TI  - Mobile-centric ambient intelligence in health- and homecare-anticipating ethical 
      and legal challenges.
PG  - 303-23
LID - 10.1007/s11948-009-9150-5 [doi]
AB  - Ambient Intelligence provides the potential for vast and varied applications,
      bringing with it both promise and peril. The development of Ambient Intelligence 
      applications poses a number of ethical and legal concerns. Mobile devices are
      increasingly evolving into tools to orientate in and interact with the
      environment, thus introducing a user-centric approach to Ambient Intelligence.
      The MINAmI (Micro-Nano integrated platform for transverse Ambient Intelligence
      applications) FP6 research project aims at creating core technologies for mobile 
      device based Ambient Intelligence services. In this paper we assess five
      scenarios that demonstrate forthcoming MINAmI-based applications focusing on
      healthcare, assistive technology, homecare, and everyday life in general. A legal
      and ethical analysis of the scenarios is conducted, which reveals various
      conflicting interests. The paper concludes with some thoughts on drafting ethical
      guidelines for Ambient Intelligence applications.
FAU - Kosta, Eleni
AU  - Kosta E
AD  - Interdisciplinary Centre for Law & ICT (ICRI), KU Leuven, IBBT,
      Sint-Michielsstraat 6, 3000 Leuven, Belgium. eleni.kosta@law.kuleuven.be
FAU - Pitkanen, Olli
AU  - Pitkanen O
FAU - Niemela, Marketta
AU  - Niemela M
FAU - Kaasinen, Eija
AU  - Kaasinen E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090714
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Cell Phone/ethics/legislation & jurisprudence
MH  - Computer Security
MH  - Confidentiality
MH  - Drug Monitoring
MH  - Ethical Analysis
MH  - *Home Care Services/ethics/legislation & jurisprudence
MH  - Humans
MH  - Microtechnology
MH  - *Monitoring, Ambulatory/ethics
MH  - *Nanomedicine/ethics/legislation & jurisprudence
MH  - Patient Advocacy
MH  - Polysomnography
MH  - Practice Guidelines as Topic
MH  - Principle-Based Ethics
MH  - Self-Help Devices/ethics
MH  - Technology Assessment, Biomedical/ethics/legislation & jurisprudence
MH  - *Telemedicine/ethics/legislation & jurisprudence
MH  - United States
MH  - User-Computer Interface
EDAT- 2009/07/15 09:00
MHDA- 2010/09/24 06:00
CRDT- 2009/07/15 09:00
PHST- 2009/01/22 00:00 [received]
PHST- 2009/06/19 00:00 [accepted]
PHST- 2009/07/15 09:00 [entrez]
PHST- 2009/07/15 09:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
AID - 10.1007/s11948-009-9150-5 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2010 Jun;16(2):303-23. doi: 10.1007/s11948-009-9150-5. Epub 2009 
      Jul 14.


PMID- 19597743
OWN - NLM
STAT- MEDLINE
DCOM- 20100708
LR  - 20211020
IS  - 1433-7339 (Electronic)
IS  - 0941-4355 (Linking)
VI  - 18
IP  - 5
DP  - 2010 May
TI  - Competing discourses in palliative care.
PG  - 573-82
LID - 10.1007/s00520-009-0691-6 [doi]
AB  - BACKGROUND: Palliative care focuses on early identification as well as prevention
      and alleviation of suffering. Previous studies have established that palliative
      care is a disciplinary area in a state of transformation due to the involvement
      of different professional categories and that nursing care in the palliative
      context is influenced by the dominance of the medical perspective. AIM: This
      study aimed to describe palliative care from a nursing perspective prior to the
      implementation of a palliative care programme. PATIENTS AND METHODS: The approach
      was inspired by the ethnographic method and a constructionist perspective was
      used as a theoretical framework, as the focus was on existing palliative care
      discourses. Field studies were conducted on a ward where palliative care was
      provided to patients at the end of life. Approval for the study was granted by
      the Ethics Committee at Sahlgrenska Academy. Data were collected by means of
      participant field studies, informal deliberations and other relevant documents.
      MAIN RESULTS: Four different discourses were discerned: caring, non-caring,
      curing and the organisation. CONCLUSIONS: The ethos on the ward was strongly
      linked to the medical discourse. We consider that a prerequisite for the
      organisation of palliative care is an expressed caring perspective based on the
      patients' experiences of suffering, which perspective is lacking in the curing
      and organisational discourses.
FAU - Dahlborg-Lyckhage, Elisabeth
AU  - Dahlborg-Lyckhage E
AD  - Institute of Nursing, Health and Culture, University College West, SE-461 86
      Trollhattan, Sweden. elisabeth.dahlborg-lyckhage@hv.se
FAU - Liden, Eva
AU  - Liden E
LA  - eng
PT  - Journal Article
DEP - 20090712
PL  - Germany
TA  - Support Care Cancer
JT  - Supportive care in cancer : official journal of the Multinational Association of 
      Supportive Care in Cancer
JID - 9302957
SB  - IM
MH  - Humans
MH  - Interviews as Topic
MH  - *Nursing Care
MH  - Observation
MH  - *Palliative Care/organization & administration
MH  - Sweden
MH  - Terminal Care
EDAT- 2009/07/15 09:00
MHDA- 2010/07/09 06:00
CRDT- 2009/07/15 09:00
PHST- 2009/02/03 00:00 [received]
PHST- 2009/06/24 00:00 [accepted]
PHST- 2009/07/15 09:00 [entrez]
PHST- 2009/07/15 09:00 [pubmed]
PHST- 2010/07/09 06:00 [medline]
AID - 10.1007/s00520-009-0691-6 [doi]
PST - ppublish
SO  - Support Care Cancer. 2010 May;18(5):573-82. doi: 10.1007/s00520-009-0691-6. Epub 
      2009 Jul 12.


PMID- 19594726
OWN - NLM
STAT- MEDLINE
DCOM- 20110310
LR  - 20101029
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 24
IP  - 9
DP  - 2010 Nov
TI  - Moral fictions and medical ethics.
PG  - 453-60
LID - 10.1111/j.1467-8519.2009.01738.x [doi]
AB  - Conventional medical ethics and the law draw a bright line distinguishing the
      permitted practice of withdrawing life-sustaining treatment from the forbidden
      practice of active euthanasia by means of a lethal injection. When clinicians
      justifiably withdraw life-sustaining treatment, they allow patients to die but do
      not cause, intend, or have moral responsibility for, the patient's death. In
      contrast, physicians unjustifiably kill patients whenever they intentionally
      administer a lethal dose of medication. We argue that the differential moral
      assessment of these two practices is based on a series of moral fictions -
      motivated false beliefs that erroneously characterize withdrawing life-sustaining
      treatment in order to bring accepted end-of-life practices in line with the
      prevailing moral norm that doctors must never kill patients. When these moral
      fictions are exposed, it becomes apparent that conventional medical ethics
      relating to end-of-life decisions is radically mistaken.
CI  - (c) 2009 Blackwell Publishing Ltd.
FAU - Miller, Franklin G
AU  - Miller FG
AD  - Department of Bioethics, Clinical Center, National Institutes of Health,
      Bethesda, MD 20892-1156, USA. fmiller@nih.gov
FAU - Truog, Robert D
AU  - Truog RD
FAU - Brock, Dan W
AU  - Brock DW
LA  - eng
PT  - Journal Article
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Decision Making/ethics
MH  - Ethics, Clinical
MH  - Ethics, Medical
MH  - Euthanasia, Active/*ethics/legislation & jurisprudence
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Morals
MH  - Quadriplegia
MH  - United States
MH  - Withholding Treatment/*ethics/legislation & jurisprudence
EDAT- 2009/07/15 09:00
MHDA- 2011/03/11 06:00
CRDT- 2009/07/15 09:00
PHST- 2009/07/15 09:00 [entrez]
PHST- 2009/07/15 09:00 [pubmed]
PHST- 2011/03/11 06:00 [medline]
AID - BIOT1738 [pii]
AID - 10.1111/j.1467-8519.2009.01738.x [doi]
PST - ppublish
SO  - Bioethics. 2010 Nov;24(9):453-60. doi: 10.1111/j.1467-8519.2009.01738.x.


PMID- 19585247
OWN - NLM
STAT- MEDLINE
DCOM- 20100222
LR  - 20180202
IS  - 1573-1677 (Electronic)
IS  - 1382-4996 (Linking)
VI  - 15
IP  - 1
DP  - 2010 Mar
TI  - Professional competencies in health sciences education: from multiple
      intelligences to the clinic floor.
PG  - 129-146
LID - 10.1007/s10459-009-9172-4 [doi]
AB  - Nontechnical competencies identified as essential to the health professional's
      success include ethical behavior, interpersonal, self-management, leadership,
      business, and thinking competencies. The literature regarding such diverse
      topics, and the literature regarding "professional success" is extensive and
      wide-ranging, crossing educational, psychological, business, medical and
      vocational fields of study. This review is designed to introduce ways of viewing 
      nontechnical competence from the psychology of human capacity to current
      perspectives, initiatives and needs in practice. After an introduction to the
      tensions inherent in educating individuals for both biomedical competency and
      "bedside" or "cageside" manner, the paper presents a brief overview of the major 
      lines of inquiry into intelligence theory and how theories of multiple
      intelligences can build a foundation for conceptualizing professional and life
      skills. The discussion then moves from broad concepts of intelligence to more
      specific workplace skill sets, with an emphasis on professional medical
      education. This section introduces the research on noncognitive variables in
      various disciplines, the growing emphasis on competency based education, and the 
      SKA movement in veterinary education. The next section presents the evidence that
      nontechnical, noncognitive or humanistic skills influence achievement in academic
      settings, medical education and clinical performance, as well as the challenges
      faced when educational priorities must be made.
FAU - Lane, India F
AU  - Lane IF
AD  - The University of Tennessee College of Veterinary Medicine, C247 VTH, 2407 River 
      Drive, Knoxville, TN, 37996-4544, USA. ilane@utk.edu.
LA  - eng
PT  - Journal Article
DEP - 20090708
PL  - Netherlands
TA  - Adv Health Sci Educ Theory Pract
JT  - Advances in health sciences education : theory and practice
JID - 9612021
SB  - IM
CIN - Adv Health Sci Educ Theory Pract. 2010 Mar;15(1):1-8. PMID: 19924553
MH  - Cognition/classification
MH  - Communication
MH  - Health Personnel/*education
MH  - Humans
MH  - Knowledge
MH  - Learning
MH  - Personality
MH  - *Professional Competence
MH  - Terminology as Topic
EDAT- 2009/07/09 09:00
MHDA- 2010/02/23 06:00
CRDT- 2009/07/09 09:00
PHST- 2009/02/08 00:00 [received]
PHST- 2009/06/10 00:00 [accepted]
PHST- 2009/07/09 09:00 [entrez]
PHST- 2009/07/09 09:00 [pubmed]
PHST- 2010/02/23 06:00 [medline]
AID - 10.1007/s10459-009-9172-4 [doi]
AID - 10.1007/s10459-009-9172-4 [pii]
PST - ppublish
SO  - Adv Health Sci Educ Theory Pract. 2010 Mar;15(1):129-146. doi:
      10.1007/s10459-009-9172-4. Epub 2009 Jul 8.


PMID- 19581014
OWN - NLM
STAT- MEDLINE
DCOM- 20100712
LR  - 20181201
IS  - 1879-0887 (Electronic)
IS  - 0167-8140 (Linking)
VI  - 95
IP  - 1
DP  - 2010 Apr
TI  - Trials and tribulations in charged particle radiotherapy.
PG  - 23-31
LID - 10.1016/j.radonc.2009.06.012 [doi]
AB  - A number of aspects of radiotherapy using protons and ions such as carbon and
      neon are discussed, focusing less on the oft-enumerated advantages or potential
      advantages of these particles as on those aspects which are, or may be,
      problematic. First, for protons and so-called heavy ions separately, the
      potential advantages and disadvantages of the particles, on physical and
      radiobiological grounds, are reviewed and some outstanding problems, both
      technical and scientific, are enumerated. Then, mention is made of the danger
      that financial pressures can lead to suboptimal medical care of patients.
      Finally, the issue of clinical trials, and especially randomized clinical trials,
      is addressed. On the one hand, very few randomized trials have been reported. On 
      the other hand, there is a widespread desire to see trials of charged particle
      therapy undertaken. The ethical considerations are briefly reviewed and it is
      concluded that they pose strong limitations on the types of trials which can be
      undertaken. Nevertheless, some clinical trials would certainly be appropriate and
      desirable and a number are suggested, under the categories of retrospective
      non-randomized clinical trials, prospective non-randomized clinical trials, and
      prospective-randomized clinical trials.
CI  - Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
FAU - Goitein, Michael
AU  - Goitein M
AD  - Harvard Medical School, Boston, USA. michael@goitein.ch
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20090704
PL  - Ireland
TA  - Radiother Oncol
JT  - Radiotherapy and oncology : journal of the European Society for Therapeutic
      Radiology and Oncology
JID - 8407192
RN  - 7440-44-0 (Carbon)
SB  - IM
MH  - *Carbon
MH  - *Heavy Ion Radiotherapy
MH  - Humans
MH  - Linear Energy Transfer
MH  - Neoplasms/*radiotherapy
MH  - *Proton Therapy
MH  - Radiotherapy, Intensity-Modulated
MH  - Randomized Controlled Trials as Topic/ethics
RF  - 49
EDAT- 2009/07/08 09:00
MHDA- 2010/07/14 06:00
CRDT- 2009/07/08 09:00
PHST- 2009/03/17 00:00 [received]
PHST- 2009/06/02 00:00 [revised]
PHST- 2009/06/08 00:00 [accepted]
PHST- 2009/07/08 09:00 [entrez]
PHST- 2009/07/08 09:00 [pubmed]
PHST- 2010/07/14 06:00 [medline]
AID - S0167-8140(09)00316-8 [pii]
AID - 10.1016/j.radonc.2009.06.012 [doi]
PST - ppublish
SO  - Radiother Oncol. 2010 Apr;95(1):23-31. doi: 10.1016/j.radonc.2009.06.012. Epub
      2009 Jul 4.


PMID- 19573872
OWN - NLM
STAT- MEDLINE
DCOM- 20100309
LR  - 20220321
IS  - 1873-491X (Electronic)
IS  - 0020-7489 (Linking)
VI  - 47
IP  - 1
DP  - 2010 Jan
TI  - Registered nurses' and nurse assistants' lived experience of troubled conscience 
      in their work in elderly care--a phenomenological hermeneutic study.
PG  - 20-9
LID - 10.1016/j.ijnurstu.2009.06.001 [doi]
AB  - BACKGROUND: In elderly care registered nurses (RNs) and nurse assistants (NAs)
      face ethical challenges which may trouble their conscience. OBJECTIVE: This study
      aimed to illuminate meanings of RNs' and NAs' lived experience of troubled
      conscience in their work in municipal residential elderly care. DESIGN:
      Interviews with six RNs and six NAs were interpreted separately using a
      phenomenological hermeneutic method. SETTINGS: Data was collected in 2005 among
      RNs and NAs working in special types of housings for the elderly in a
      municipality in Sweden. PARTICIPANTS: The RNs and NAs were selected for
      participation had previously participated in a questionnaire study and their
      ratings in the questionnaire study constituted the selection criteria for the
      interview study. RESULTS: The RNs' lived experience of troubled conscience was
      formulated in two themes. The first theme is 'being trapped in powerlessness'
      which includes three sub-themes: being restrained by others' omission, being
      trapped in ethically demanding situations and failing to live up to others'
      expectations. The second theme is 'being inadequate' which includes two
      sub-themes: lacking courage to maintain one's opinion and feeling incompetent.
      The NAs' lived experience of troubled conscience was formulated in the two
      themes. The first is 'being hindered by pre-determined conditions' which includes
      two sub-themes: suffering from lack of focus in one's work and being restrained
      by the organisation. The second theme is 'being inadequate' which includes two
      sub-themes: lacking the courage to object and being negligent. CONCLUSIONS: The
      RNs' lived experience of troubled conscience were feelings of being trapped in a 
      state of powerlessness, caught in a struggle between responsibility and authority
      and a sense of inadequacy fuelled by feelings of incompetence, a lack of courage 
      and a fear of revealing themselves and endangering residents' well-being. The
      NAs' lived experience of troubled conscience was feelings of being hindered by
      pre-determined conditions, facing a fragmented work situation hovering between
      norms and rules and convictions of their conscience. To not endangering the
      atmosphere in the work-team they are submissive to the norms of their co-workers.
      They felt inadequate as they should be model care providers. The findings were
      interpreted in the light of Fromm's authoritarian and humanistic conscience.
FAU - Juthberg, C
AU  - Juthberg C
AD  - Department of Nursing, Umea University, SE 901 87 Umea, Sweden.
      christina.juthberg@nurs.umu.se
FAU - Sundin, K
AU  - Sundin K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090701
PL  - England
TA  - Int J Nurs Stud
JT  - International journal of nursing studies
JID - 0400675
SB  - IM
MH  - Aged
MH  - *Geriatric Nursing
MH  - Humans
MH  - Narration
MH  - Nurses/*psychology
MH  - Nursing Assistants/*psychology
MH  - Sweden
MH  - Workforce
EDAT- 2009/07/04 09:00
MHDA- 2010/03/10 06:00
CRDT- 2009/07/04 09:00
PHST- 2009/03/02 00:00 [received]
PHST- 2009/06/02 00:00 [revised]
PHST- 2009/06/02 00:00 [accepted]
PHST- 2009/07/04 09:00 [entrez]
PHST- 2009/07/04 09:00 [pubmed]
PHST- 2010/03/10 06:00 [medline]
AID - S0020-7489(09)00183-7 [pii]
AID - 10.1016/j.ijnurstu.2009.06.001 [doi]
PST - ppublish
SO  - Int J Nurs Stud. 2010 Jan;47(1):20-9. doi: 10.1016/j.ijnurstu.2009.06.001. Epub
      2009 Jul 1.


PMID- 19560237
OWN - NLM
STAT- MEDLINE
DCOM- 20100222
LR  - 20161125
IS  - 1532-2793 (Electronic)
IS  - 0260-6917 (Linking)
VI  - 30
IP  - 1
DP  - 2010 Jan
TI  - Involving the stakeholders in the curriculum process: a recipe for success?
PG  - 37-43
LID - 10.1016/j.nedt.2009.05.017 [doi]
AB  - The Department of Nursing and Health Studies at the Manukau Institute of
      Technology (MIT) in Auckland, New Zealand, decided to involve stakeholders from
      the health care sector in developing a new curriculum. After implementing the new
      curriculum, the process was evaluated using a content analysis as qualitative
      research design. Seven individual interviews and one Focus group interview were
      conducted with the stakeholders to determine their experiences during the
      process. Ethical permission was sought from the MIT ethical committee. The
      analyses of the collected data enabled the researchers to identify six main
      categories. The categories were: "Existing Programme", "The need to change", "The
      curriculum development process", "The stakeholders", "Personnel", and "Ethnic
      minorities". From the collected data, it was clear that a new curriculum was
      necessary to enable the graduates to meet the health care needs of the New
      Zealand population, especially after the primary health care policy was
      introduced in New Zealand. It was also clear that the curriculum development
      process could be a painful process for all concerned, but a strong leadership
      could cement a feeling of "collegiality" between stakeholders and teaching staff.
      The importance of considering the rights of ethnic minorities is clearly stated
      in the Treaty of Waitangi, safeguarding the rights of the Maori People, and
      therefore applied rigorously in the development process. In this project, the
      collaborative process was very successful, and the stakeholders actually
      expressed feelings of "Ownership" of the curriculum.
FAU - Keogh, Johannes J
AU  - Keogh JJ
AD  - Department of Nursing and Health Sciences, Fulda University of Applied Sciences, 
      36039 Fulda, Germany. jan.keogh@pg.hs-fulda.de
FAU - Fourie, Willem J
AU  - Fourie WJ
FAU - Watson, Sheona
AU  - Watson S
FAU - Gay, H
AU  - Gay H
LA  - eng
PT  - Journal Article
PL  - Scotland
TA  - Nurse Educ Today
JT  - Nurse education today
JID - 8511379
MH  - *Attitude of Health Personnel
MH  - *Attitude to Health
MH  - Community Participation/*methods/psychology
MH  - Cultural Competency/education
MH  - *Curriculum
MH  - *Decision Making, Organizational
MH  - Education, Nursing, Baccalaureate/*organization & administration
MH  - Faculty, Nursing/organization & administration
MH  - Focus Groups
MH  - Humans
MH  - Minority Groups/psychology
MH  - Needs Assessment
MH  - New Zealand
MH  - Nursing Education Research
MH  - Nursing Methodology Research
MH  - Organizational Innovation
MH  - Program Development/methods
MH  - Qualitative Research
MH  - Students, Nursing/psychology
EDAT- 2009/06/30 09:00
MHDA- 2010/02/23 06:00
CRDT- 2009/06/30 09:00
PHST- 2008/03/16 00:00 [received]
PHST- 2009/05/23 00:00 [revised]
PHST- 2009/05/28 00:00 [accepted]
PHST- 2009/06/30 09:00 [entrez]
PHST- 2009/06/30 09:00 [pubmed]
PHST- 2010/02/23 06:00 [medline]
AID - S0260-6917(09)00112-9 [pii]
AID - 10.1016/j.nedt.2009.05.017 [doi]
PST - ppublish
SO  - Nurse Educ Today. 2010 Jan;30(1):37-43. doi: 10.1016/j.nedt.2009.05.017.


PMID- 19556749
OWN - NLM
STAT- MEDLINE
DCOM- 20100218
LR  - 20091209
IS  - 1662-8063 (Electronic)
IS  - 1662-4246 (Linking)
VI  - 13
IP  - 2
DP  - 2010
TI  - Population screening for genetic disorders in the 21st century: evidence,
      economics, and ethics.
PG  - 106-15
LID - 10.1159/000226594 [doi]
AB  - BACKGROUND: Proposals for population screening for genetic diseases require
      careful scrutiny by decision makers because of the potential for harms and the
      need to demonstrate benefits commensurate with the opportunity cost of resources 
      expended. METHODS: We review current evidence-based processes used in the United 
      States, the United Kingdom, and the Netherlands to assess genetic screening
      programs, including newborn screening programs, carrier screening, and organized 
      cascade testing of relatives of patients with genetic syndromes. In particular,
      we address critical evidentiary, economic, and ethical issues that arise in the
      appraisal of screening tests offered to the population. Specific case studies
      include newborn screening for congenital adrenal hyperplasia and cystic fibrosis 
      and adult screening for hereditary hemochromatosis. RESULTS: Organizations and
      countries often reach different conclusions about the suitability of screening
      tests for implementation on a population basis. Deciding when and how to
      introduce pilot screening programs is challenging. In certain cases, e.g.,
      hereditary hemochromatosis, a consensus does not support general screening
      although cascade screening may be cost-effective. CONCLUSION: Genetic screening
      policies have often been determined by technological capability, advocacy, and
      medical opinion rather than through a rigorous evidence-based review process.
      Decision making should take into account principles of ethics and opportunity
      costs.
CI  - Copyright 2009 S. Karger AG, Basel.
FAU - Grosse, S D
AU  - Grosse SD
AD  - National Center on Birth Defects and Developmental Disabilities, Centers for
      Disease Control and Prevention, U.S. Department of Health and Human Services,
      Atlanta, GA 30333, USA. sgg4@cdc.gov
FAU - Rogowski, W H
AU  - Rogowski WH
FAU - Ross, L F
AU  - Ross LF
FAU - Cornel, M C
AU  - Cornel MC
FAU - Dondorp, W J
AU  - Dondorp WJ
FAU - Khoury, M J
AU  - Khoury MJ
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20090629
PL  - Switzerland
TA  - Public Health Genomics
JT  - Public health genomics
JID - 101474167
SB  - IM
MH  - Cost-Benefit Analysis
MH  - *Ethics
MH  - Genetic Diseases, Inborn/*diagnosis/genetics
MH  - *Genetic Testing/economics/ethics
MH  - Humans
MH  - *Population Surveillance
RF  - 100
EDAT- 2009/06/27 09:00
MHDA- 2010/02/19 06:00
CRDT- 2009/06/27 09:00
PHST- 2009/01/08 00:00 [received]
PHST- 2009/04/14 00:00 [accepted]
PHST- 2009/06/27 09:00 [entrez]
PHST- 2009/06/27 09:00 [pubmed]
PHST- 2010/02/19 06:00 [medline]
AID - 000226594 [pii]
AID - 10.1159/000226594 [doi]
PST - ppublish
SO  - Public Health Genomics. 2010;13(2):106-15. doi: 10.1159/000226594. Epub 2009 Jun 
      29.


PMID- 19552792
OWN - NLM
STAT- MEDLINE
DCOM- 20100922
LR  - 20191210
IS  - 1471-6712 (Electronic)
IS  - 0283-9318 (Linking)
VI  - 24
IP  - 1
DP  - 2010 Mar
TI  - Evaluation of informed consent in health research: a questionnaire survey.
PG  - 56-64
LID - 10.1111/j.1471-6712.2008.00684.x [doi]
AB  - OBJECTIVE: Informed consent is ethically and legally required for all biomedical 
      and health research involving human participants. This study analyses the
      realization of informed consent in health research from the point of view of
      healthy, voluntary adult participants. Empirical studies from this point of view 
      are still rare. DESIGN: A population-based questionnaire survey. PARTICIPANTS:
      The study population consisted of 1410 men and women aged 57-78 years who are
      participants in a randomized controlled intervention trial on the effects of
      physical exercise and diet at Kuopio Research Institute of Exercise Medicine
      (eastern Finland). METHODS: The data were collected in 2005-2007 using a
      questionnaire. The questionnaire was given to all able and willing participants
      (n = 1324) who were still involved in the exercise and diet study at the 3-month 
      intervention visit. The response rate was 91%. RESULTS: The defined key elements 
      of informed consent were information, understanding, competence, voluntariness
      and decision-making. A majority of the participants estimated that these key
      elements were successfully realized in the exercise and diet intervention study. 
      CONCLUSIONS: Despite the general satisfaction with the informed consent process
      in the exercise and diet intervention study, a minority of the participants were 
      dissatisfied with the information they had received or did not understand this
      information completely. These findings highlight the essential question: Did all 
      of the participants truly give their genuine informed consent? This carefully
      executed study reveals objectively the difficulties in distribution of
      information to healthy adult volunteers.
FAU - Lansimies-Antikainen, Helena
AU  - Lansimies-Antikainen H
AD  - Department of Nursing Science, University of Kuopio, Kuopio, Finland.
      ahantika@hytti.uku.fi
FAU - Laitinen, Tomi
AU  - Laitinen T
FAU - Rauramaa, Rainer
AU  - Rauramaa R
FAU - Pietila, Anna-Maija
AU  - Pietila AM
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20090623
PL  - Sweden
TA  - Scand J Caring Sci
JT  - Scandinavian journal of caring sciences
JID - 8804206
MH  - Aged
MH  - *Biomedical Research
MH  - *Delivery of Health Care
MH  - Female
MH  - Humans
MH  - Informed Consent/*ethics/*standards
MH  - Male
MH  - Middle Aged
MH  - Surveys and Questionnaires
EDAT- 2009/06/26 09:00
MHDA- 2010/09/24 06:00
CRDT- 2009/06/26 09:00
PHST- 2009/06/26 09:00 [entrez]
PHST- 2009/06/26 09:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
AID - SCS684 [pii]
AID - 10.1111/j.1471-6712.2008.00684.x [doi]
PST - ppublish
SO  - Scand J Caring Sci. 2010 Mar;24(1):56-64. doi: 10.1111/j.1471-6712.2008.00684.x. 
      Epub 2009 Jun 23.


PMID- 19551493
OWN - NLM
STAT- MEDLINE
DCOM- 20100603
LR  - 20211020
IS  - 1573-7292 (Electronic)
IS  - 1389-9600 (Linking)
VI  - 9
IP  - 1
DP  - 2010 Mar
TI  - Predictive testing for pre-malignancy as a prelude to adoption? An English case.
PG  - 71-4
LID - 10.1007/s10689-009-9261-9 [doi]
AB  - Genetic testing as a preliminary to adoption has been discussed in the literature
      [BAAF/BSHG Statement on the use of DNA testing to determine racial background],
      together with the medical benefits derived from such testing ASHG/ACMG Statement 
      [Am J Hum Genetics, 66: 761-767, 2000]. But specific cases that reach court are
      rare. Such a case was recently discussed on national radio
      [http://www.bbc.co.uk/radio4/science/ethicscommittee_s4_tr3.shtml], disclosing
      sufficient facts to allow analysis of the ethical and legal issues encountered.
      Furthermore, the outcome of the case, a court order to test the child in infancy,
      can be reviewed in the light of the current law, together with the geneticist's
      response to this order.
FAU - Wheeler, Robert
AU  - Wheeler R
AD  - Southampton University Hospital, Tremona Road, Southampton, SO16 6YD, UK.
      robert.wheeler@suht.swest.nhs.uk
LA  - eng
PT  - Journal Article
DEP - 20090624
PL  - Netherlands
TA  - Fam Cancer
JT  - Familial cancer
JID - 100898211
SB  - IM
MH  - Adoption/*legislation & jurisprudence
MH  - Child
MH  - Ethics, Medical
MH  - Genetic Counseling/ethics
MH  - Genetic Privacy
MH  - Genetic Testing/legislation & jurisprudence/*methods
MH  - Humans
MH  - Informed Consent
MH  - Neoplasms/*diagnosis/genetics
MH  - Nervous System Neoplasms/diagnosis/genetics
MH  - Risk Assessment/methods
MH  - Risk Factors
EDAT- 2009/06/25 09:00
MHDA- 2010/06/04 06:00
CRDT- 2009/06/25 09:00
PHST- 2009/02/19 00:00 [received]
PHST- 2009/06/02 00:00 [accepted]
PHST- 2009/06/25 09:00 [entrez]
PHST- 2009/06/25 09:00 [pubmed]
PHST- 2010/06/04 06:00 [medline]
AID - 10.1007/s10689-009-9261-9 [doi]
PST - ppublish
SO  - Fam Cancer. 2010 Mar;9(1):71-4. doi: 10.1007/s10689-009-9261-9. Epub 2009 Jun 24.


PMID- 19540822
OWN - NLM
STAT- MEDLINE
DCOM- 20100423
LR  - 20220316
IS  - 1878-0946 (Electronic)
IS  - 1744-165X (Linking)
VI  - 15
IP  - 1
DP  - 2010 Feb
TI  - Stem cell and genetic therapies for the fetus.
PG  - 46-51
LID - 10.1016/j.siny.2009.05.005 [doi]
AB  - Advances in prenatal diagnosis have led to the prenatal management of a variety
      of congenital diseases. Although prenatal stem cell and gene therapy await
      clinical application, they offer tremendous potential for the treatment of many
      genetic disorders. Normal developmental events in the fetus offer unique biologic
      advantages for the engraftment of hematopoietic stem cells and efficient gene
      transfer that are not present after birth. Although barriers to hematopoietic
      stem cell engraftment exist, progress has been made and preclinical studies are
      now underway for strategies based on prenatal tolerance induction to facilitate
      postnatal cellular transplantation. Similarly, in-utero gene therapy shows
      experimental promise for a host of diseases and proof-in-principle has been
      demonstrated in murine models, but ethical and safety issues still need to be
      addressed. Here we review the current status and future potential of prenatal
      cellular and genetic therapy.
CI  - Copyright 2009 Elsevier Ltd. All rights reserved.
FAU - Roybal, Jessica L
AU  - Roybal JL
AD  - Children's Center for Fetal Research, Children's Hospital of Philadelphia, PA,
      USA.
FAU - Santore, Matthew T
AU  - Santore MT
FAU - Flake, Alan W
AU  - Flake AW
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20090621
PL  - Netherlands
TA  - Semin Fetal Neonatal Med
JT  - Seminars in fetal & neonatal medicine
JID - 101240003
SB  - IM
MH  - Animals
MH  - Fetal Diseases/*therapy
MH  - Gene Transfer Techniques
MH  - Genetic Therapy/adverse effects/*methods/trends
MH  - Hematopoietic Stem Cell Transplantation/*methods/trends
MH  - Humans
MH  - Immune Tolerance
RF  - 50
EDAT- 2009/06/23 09:00
MHDA- 2010/04/24 06:00
CRDT- 2009/06/23 09:00
PHST- 2009/06/23 09:00 [entrez]
PHST- 2009/06/23 09:00 [pubmed]
PHST- 2010/04/24 06:00 [medline]
AID - S1744-165X(09)00051-1 [pii]
AID - 10.1016/j.siny.2009.05.005 [doi]
PST - ppublish
SO  - Semin Fetal Neonatal Med. 2010 Feb;15(1):46-51. doi: 10.1016/j.siny.2009.05.005. 
      Epub 2009 Jun 21.


PMID- 19531523
OWN - NLM
STAT- MEDLINE
DCOM- 20100127
LR  - 20091230
IS  - 1468-2044 (Electronic)
IS  - 0003-9888 (Linking)
VI  - 95
IP  - 1
DP  - 2010 Jan
TI  - An ethical approach to resolving value conflicts in child protection.
PG  - 55-8
LID - 10.1136/adc.2009.158667 [doi]
AB  - Child protection professionals working in diverse societies are regularly faced
      with value conflicts. Recognising these, and resolving them in the best interests
      of children, is a task that requires child protection specialists to make complex
      judgements and decisions. In this paper the philosophical concepts of absolutism 
      and relativism to child abuse are applied, and it explores how this approach has 
      practical relevance to solving ethical dilemmas in child protection. Children's
      interests are best served by erring towards an absolutist approach to the
      diagnosis and recognition of maltreatment and towards a relativistic approach in 
      determining how services respond to a harmful incident or situation. Absolutism
      and relativism are not alternatives, but part of a continuous process of
      recognising and negotiating ever-changing community, national and global norms.
      At the service level the dichotomy transpires into the need to be culturally
      competent in handling the conflicting needs, rights and values of children,
      families, communities and professionals, whilst retaining the skill of child
      advocacy.
FAU - Webb, E
AU  - Webb E
AD  - School of Medicine, Cardiff University, Cardiff, Wales, UK. webbev@cf.ac.uk
FAU - Moynihan, S
AU  - Moynihan S
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20090615
PL  - England
TA  - Arch Dis Child
JT  - Archives of disease in childhood
JID - 0372434
SB  - IM
MH  - Child
MH  - Child Abuse/*diagnosis/ethics/prevention & control
MH  - Child Advocacy/*ethics
MH  - Ethical Theory
MH  - Humans
MH  - Philosophy, Medical
MH  - *Social Values
RF  - 38
EDAT- 2009/06/18 09:00
MHDA- 2010/01/28 06:00
CRDT- 2009/06/18 09:00
PHST- 2009/06/18 09:00 [entrez]
PHST- 2009/06/18 09:00 [pubmed]
PHST- 2010/01/28 06:00 [medline]
AID - adc.2009.158667 [pii]
AID - 10.1136/adc.2009.158667 [doi]
PST - ppublish
SO  - Arch Dis Child. 2010 Jan;95(1):55-8. doi: 10.1136/adc.2009.158667. Epub 2009 Jun 
      15.


PMID- 19523890
OWN - NLM
STAT- MEDLINE
DCOM- 20100402
LR  - 20100204
IS  - 1878-0539 (Electronic)
IS  - 1748-6815 (Linking)
VI  - 63
IP  - 1
DP  - 2010 Jan
TI  - The use of the artificial dermis (Integra) in combination with vacuum assisted
      closure for reconstruction of an extensive burn scar--a case report.
PG  - e32-5
LID - 10.1016/j.bjps.2009.05.022 [doi]
AB  - The artificial dermis Integra (Ethicon, Johnson & Johnson Medical, Norderstedt,
      Germany) is widely used in the treatment of excessive burn injuries. It is also
      used in reconstructive surgery when large soft-tissue defects could not be
      covered with local or free flaps. In this article a 25-year old patient who
      presented with an early childhood burn of the trunk and lower extremity was
      treated with Integra in combination with the vacuum assisted closure (V.A.C.,
      KCI, Texas, U.S.A.) and split thickness skin grafting. The combination of the
      artificial dermal substitute with negative pressure therapy has lead to a
      complete healing of Integra and the skin graft. During the whole treatment
      sterile wound conditions were present and time-consuming dressing changes could
      be prevented. Hospital stay was shortened because the patient could be treated as
      an outpatient with an ambulant vacuum assisted closure device.
CI  - Copyright (c) 2009 British Association of Plastic, Reconstructive and Aesthetic
      Surgeons. Published by Elsevier Ltd. All rights reserved.
FAU - Leffler, M
AU  - Leffler M
AD  - Department of Plastic and Hand Surgery, University Hospital Erlangen,
      Krankenhausstrasse 12, D-91054 Erlangen, Germany. Mareike.Leffler@uk-erlangen.de
FAU - Horch, R E
AU  - Horch RE
FAU - Dragu, A
AU  - Dragu A
FAU - Bach, A D
AU  - Bach AD
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20090611
PL  - Netherlands
TA  - J Plast Reconstr Aesthet Surg
JT  - Journal of plastic, reconstructive & aesthetic surgery : JPRAS
JID - 101264239
RN  - 0 (integra artificial skin)
RN  - 9007-28-7 (Chondroitin Sulfates)
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Adult
MH  - Burns/*surgery
MH  - Buttocks
MH  - *Chondroitin Sulfates
MH  - Cicatrix/*surgery
MH  - *Collagen
MH  - Humans
MH  - Leg
MH  - Male
MH  - Reconstructive Surgical Procedures/*methods
MH  - Skin Transplantation
MH  - Thorax
MH  - Vacuum
EDAT- 2009/06/16 09:00
MHDA- 2010/04/03 06:00
CRDT- 2009/06/16 09:00
PHST- 2009/02/13 00:00 [received]
PHST- 2009/04/29 00:00 [revised]
PHST- 2009/05/11 00:00 [accepted]
PHST- 2009/06/16 09:00 [entrez]
PHST- 2009/06/16 09:00 [pubmed]
PHST- 2010/04/03 06:00 [medline]
AID - S1748-6815(09)00401-X [pii]
AID - 10.1016/j.bjps.2009.05.022 [doi]
PST - ppublish
SO  - J Plast Reconstr Aesthet Surg. 2010 Jan;63(1):e32-5. doi:
      10.1016/j.bjps.2009.05.022. Epub 2009 Jun 11.


PMID- 19515512
OWN - NLM
STAT- MEDLINE
DCOM- 20100414
LR  - 20191210
IS  - 1879-355X (Electronic)
IS  - 0360-3016 (Linking)
VI  - 76
IP  - 5
DP  - 2010 Apr
TI  - Clinical evaluation of stereotactic target localization using 3-Tesla MRI for
      radiosurgery planning.
PG  - 1472-9
LID - 10.1016/j.ijrobp.2009.03.020 [doi]
AB  - PURPOSE: Increasing the magnetic resonance imaging (MRI) field strength can
      improve image resolution and quality, but concerns remain regarding the influence
      on geometric fidelity. The objectives of the present study were to spatially
      investigate the effect of 3-Tesla (3T) MRI on clinical target localization for
      stereotactic radiosurgery. METHODS AND MATERIALS: A total of 39 patients were
      enrolled in a research ethics board-approved prospective clinical trial. Imaging 
      (1.5T and 3T MRI and computed tomography) was performed after stereotactic frame 
      placement. Stereotactic target localization at 1.5T vs. 3T was retrospectively
      analyzed in a representative cohort of patients with tumor (n = 4) and functional
      (n = 5) radiosurgical targets. The spatial congruency of the tumor gross target
      volumes was determined by the mean discrepancy between the average gross target
      volume surfaces at 1.5T and 3T. Reproducibility was assessed by the displacement 
      from an averaged surface and volume congruency. Spatial congruency and the
      reproducibility of functional radiosurgical targets was determined by comparing
      the mean and standard deviation of the isocenter coordinates. RESULTS: Overall,
      the mean absolute discrepancy across all patients was 0.67 mm (95% confidence
      interval, 0.51-0.83), significantly <1 mm (p < .010). No differences were found
      in the overall interuser target volume congruence (mean, 84% for 1.5T vs. 84% for
      3T, p > .4), and the gross target volume surface mean displacements were similar 
      within and between users. The overall average isocenter coordinate discrepancy
      for the functional targets at 1.5T and 3T was 0.33 mm (95% confidence interval,
      0.20-0.48), with no patient-specific differences between the mean values (p >.2) 
      or standard deviations (p >.1). CONCLUSION: Our results have provided clinically 
      relevant evidence supporting the spatial validity of 3T MRI for use in
      stereotactic radiosurgery under the imaging conditions used.
FAU - MacFadden, Derek
AU  - MacFadden D
AD  - University of Toronto Faculty of Medicine, Toronto, ON, Canada.
FAU - Zhang, BeiBei
AU  - Zhang B
FAU - Brock, Kristy K
AU  - Brock KK
FAU - Hodaie, Mojgan
AU  - Hodaie M
FAU - Laperriere, Normand
AU  - Laperriere N
FAU - Schwartz, Michael
AU  - Schwartz M
FAU - Tsao, May
AU  - Tsao M
FAU - Stainsby, Jeffrey
AU  - Stainsby J
FAU - Lockwood, Gina
AU  - Lockwood G
FAU - Mikulis, David
AU  - Mikulis D
FAU - Menard, Cynthia
AU  - Menard C
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090608
PL  - United States
TA  - Int J Radiat Oncol Biol Phys
JT  - International journal of radiation oncology, biology, physics
JID - 7603616
SB  - IM
MH  - Brain Neoplasms/*pathology/*radiotherapy
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods/standards
MH  - Prospective Studies
MH  - *Radiosurgery
MH  - Radiotherapy Planning, Computer-Assisted/*methods
MH  - Reproducibility of Results
MH  - *Tumor Burden
EDAT- 2009/06/12 09:00
MHDA- 2010/04/15 06:00
CRDT- 2009/06/12 09:00
PHST- 2008/07/04 00:00 [received]
PHST- 2009/02/11 00:00 [revised]
PHST- 2009/03/19 00:00 [accepted]
PHST- 2009/06/12 09:00 [entrez]
PHST- 2009/06/12 09:00 [pubmed]
PHST- 2010/04/15 06:00 [medline]
AID - S0360-3016(09)00437-4 [pii]
AID - 10.1016/j.ijrobp.2009.03.020 [doi]
PST - ppublish
SO  - Int J Radiat Oncol Biol Phys. 2010 Apr;76(5):1472-9. doi:
      10.1016/j.ijrobp.2009.03.020. Epub 2009 Jun 8.


PMID- 19508307
OWN - NLM
STAT- MEDLINE
DCOM- 20110310
LR  - 20211020
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 24
IP  - 9
DP  - 2010 Nov
TI  - Virtue ethics and the selection of children with impairments: a reply to Rosalind
      McDougall.
PG  - 499-506
LID - 10.1111/j.1467-8519.2009.01732.x [doi]
AB  - In 'Parental Virtues: A New Way of Thinking about the Morality of Reproductive
      Actions' Rosalind McDougall proposes a virtue-based framework to assess the
      morality of child selection. Applying the virtue-based account to the selection
      of children with impairments does not lead, according to McDougall, to an
      unequivocal answer to the morality of selecting impaired children. In
      'Impairment, Flourishing, and the Moral Nature of Parenthood,' she also applies
      the virtue-based account to the discussion of child selection, and claims that
      couples with an impairment are morally justified in selecting a child with the
      same impairment. This claim, she maintains, reveals that the flourishing of a
      child should be understood as requiring environment-specific characteristics. I
      argue that McDougall's argument begs the question. More importantly, it does not 
      do justice to virtue ethics. I also question to what extent a virtue ethics
      framework can be successfully applied to discussions about the moral
      permissibility of reproductive actions.
CI  - (c) 2009 Blackwell Publishing Ltd.
FAU - Saenz, Carla
AU  - Saenz C
AD  - Department of Bioethics, Clinical Center, National Institutes of Health,
      Bethesda, MD 20892-1156, USA. saenzca@cc.nih.gov
LA  - eng
PT  - Journal Article
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Deafness
MH  - Disabled Persons/*psychology
MH  - Ethical Analysis
MH  - Ethical Theory
MH  - *Eugenics
MH  - Humans
MH  - Moral Obligations
MH  - Parents/*psychology
MH  - Reproduction/*ethics
MH  - *Virtues
PMC - PMC2888959
MID - NIHMS138739
EDAT- 2009/06/11 09:00
MHDA- 2011/03/11 06:00
CRDT- 2009/06/11 09:00
PHST- 2009/06/11 09:00 [entrez]
PHST- 2009/06/11 09:00 [pubmed]
PHST- 2011/03/11 06:00 [medline]
AID - BIOT1732 [pii]
AID - 10.1111/j.1467-8519.2009.01732.x [doi]
PST - ppublish
SO  - Bioethics. 2010 Nov;24(9):499-506. doi: 10.1111/j.1467-8519.2009.01732.x.


PMID- 19508291
OWN - NLM
STAT- MEDLINE
DCOM- 20100819
LR  - 20100714
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 10
IP  - 2
DP  - 2010 Aug
TI  - Reproductive tourism in Argentina: clinic accreditation and its implications for 
      consumers, health professionals and policy makers.
PG  - 59-69
LID - 10.1111/j.1471-8847.2009.00256.x [doi]
AB  - A subcategory of medical tourism, reproductive tourism has been the subject of
      much public and policy debate in recent years. Specific concerns include: the
      exploitation of individuals and communities, access to needed health care
      services, fair allocation of limited resources, and the quality and safety of
      services provided by private clinics. To date, the focus of attention has been on
      the thriving medical and reproductive tourism sectors in Asia and Eastern Europe;
      there has been much less consideration given to more recent 'players' in Latin
      America, notably fertility clinics in Chile, Brazil, Mexico and Argentina. In
      this paper, we examine the context-specific ethical and policy implications of
      private Argentinean fertility clinics that market reproductive services via the
      internet. Whether or not one agrees that reproductive services should be made
      available as consumer goods, the fact is that they are provided as such by
      private clinics around the world. We argue that basic national regulatory
      mechanisms are required in countries such as Argentina that are marketing
      fertility services to local and international publics. Specifically, regular
      oversight of all fertility clinics is essential to ensure that consumer
      information is accurate and that marketed services are safe and effective. It is 
      in the best interests of consumers, health professionals and policy makers that
      the reproductive tourism industry adopts safe and responsible medical practices.
FAU - Smith, Elise
AU  - Smith E
AD  - Programmes de bioethique, Departement de medecine sociale et preventive,
      Universite de Montreal, succ. Centre-ville Montreal, Quebec, Canada.
FAU - Behrmann, Jason
AU  - Behrmann J
FAU - Martin, Carolina
AU  - Martin C
FAU - Williams-Jones, Bryn
AU  - Williams-Jones B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090608
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
SB  - IM
MH  - *Accreditation/standards/trends
MH  - Adult
MH  - *Ambulatory Care Facilities/standards
MH  - Argentina
MH  - Female
MH  - Humans
MH  - Latin America
MH  - Male
MH  - *Medical Tourism/trends
MH  - Patient Satisfaction
MH  - Private Sector
MH  - Quality of Health Care
MH  - *Reproductive Techniques, Assisted/standards
MH  - Safety
EDAT- 2009/06/11 09:00
MHDA- 2010/08/20 06:00
CRDT- 2009/06/11 09:00
PHST- 2009/06/11 09:00 [entrez]
PHST- 2009/06/11 09:00 [pubmed]
PHST- 2010/08/20 06:00 [medline]
AID - DEWB256 [pii]
AID - 10.1111/j.1471-8847.2009.00256.x [doi]
PST - ppublish
SO  - Dev World Bioeth. 2010 Aug;10(2):59-69. doi: 10.1111/j.1471-8847.2009.00256.x.
      Epub 2009 Jun 8.


PMID- 19506916
OWN - NLM
STAT- MEDLINE
DCOM- 20100922
LR  - 20211020
IS  - 1433-7339 (Electronic)
IS  - 0941-4355 (Linking)
VI  - 18
IP  - 6
DP  - 2010 Jun
TI  - Prospective survey of sexual function among patients with clinically localized
      prostate cancer referred for definitive radiotherapy and the impact of
      radiotherapy on sexual function.
PG  - 715-22
LID - 10.1007/s00520-009-0675-6 [doi]
AB  - PURPOSE: The purpose of this study is to assess sexual function among patients
      with clinically localized prostate cancer referred for radiotherapy and to
      prospectively evaluate the effect of radiotherapy on sexual function, using the
      Brief Sexual Function Inventory (BSFI). MATERIALS AND METHODS: A descriptive
      study, approved by the local research ethics committee, was prospectively
      conducted. At baseline, patients were asked to complete a self-administered BSFI,
      along with other questionnaires describing their clinical condition. Patients
      with normal erection at baseline were asked to complete a follow-up BSFI at 6,
      12, and 24 months postradiotherapy. The collected data was analyzed using the SAS
      software. RESULTS: The study accrued a total of 117 eligible patients. The mean
      age was 66 years. Forty-two patients (35.9%) were considered to have erectile
      dysfunction (ED) at baseline. They were older and more likely on one or more
      medications affecting potency, compared with those with normal erectile function.
      They had a consistently lower mean score for all the five domains of BSFI and
      considered sexual activity less important. Of the 75 patients reporting normal
      erectile function at baseline, 61 completed a follow-up BSFI questionnaire. Among
      the 61 patients, 52 underwent radiotherapy with external beam radiotherapy or
      brachytherapy. Mean scores for all the BSFI domains declined after radiotherapy, 
      suggesting that radiotherapy adversely affected not only erectile function but
      also other aspects of sexual function including sexual drive and ejaculation.
      CONCLUSION: Among the patients with clinically localized prostate cancer referred
      for radiotherapy, sexual dysfunction was prevalent with 35.9% reporting ED at
      presentation. Radiotherapy adversely affected all aspects of sexual function.
FAU - Choo, Richard
AU  - Choo R
AD  - Department of Radiation Oncology, Odette Cancer Centre, University of Toronto,
      Toronto, ON, Canada.
FAU - Long, Jennifer
AU  - Long J
FAU - Gray, Ross
AU  - Gray R
FAU - Morton, Gerard
AU  - Morton G
FAU - Gardner, Sandra
AU  - Gardner S
FAU - Danjoux, Cyril
AU  - Danjoux C
LA  - eng
PT  - Journal Article
DEP - 20090609
PL  - Germany
TA  - Support Care Cancer
JT  - Supportive care in cancer : official journal of the Multinational Association of 
      Supportive Care in Cancer
JID - 9302957
SB  - IM
MH  - Aged
MH  - Brachytherapy/*adverse effects
MH  - Erectile Dysfunction/complications/*etiology
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Ontario/epidemiology
MH  - Prevalence
MH  - Prospective Studies
MH  - Prostatic Neoplasms/complications/epidemiology/*radiotherapy
EDAT- 2009/06/10 09:00
MHDA- 2010/09/24 06:00
CRDT- 2009/06/10 09:00
PHST- 2009/02/18 00:00 [received]
PHST- 2009/05/28 00:00 [accepted]
PHST- 2009/06/10 09:00 [entrez]
PHST- 2009/06/10 09:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
AID - 10.1007/s00520-009-0675-6 [doi]
PST - ppublish
SO  - Support Care Cancer. 2010 Jun;18(6):715-22. doi: 10.1007/s00520-009-0675-6. Epub 
      2009 Jun 9.


PMID- 19506886
OWN - NLM
STAT- MEDLINE
DCOM- 20100416
LR  - 20211020
IS  - 1433-0423 (Electronic)
IS  - 0941-293X (Linking)
VI  - 107
IP  - 1
DP  - 2010 Jan
TI  - [Correction factors for central corneal thickness in Goldmann applanation
      tonometry].
PG  - 30-5
LID - 10.1007/s00347-009-1926-0 [doi]
AB  - BACKGROUND: For many years researchers have discussed which corneal parameters
      can influence the measurement of intraocular pressure (IOP). As a substantial
      parameter, the central corneal thickness (CCT) is assumed; however, different
      measuring methods - including Goldmann applanation tonometry (GAT), dynamic
      contour tonometry (DCT), and corneal compensated pressure measured with the
      ocular response analyzer (IOPcc) - may lead to a completely different dependence 
      on corneal thickness. METHOD: In a study approved by the ethics commission, the
      anterior chamber of 92 eyes of cataract patients and 85 eyes of glaucoma patients
      with very different CCT measurements was cannulized before surgery (cataract
      operation or trabeculectomy), and the IOP values were measured simultaneously
      with a pressure absorber and with GAT (Perkins tonometer) at different pressure
      values. RESULTS: The individual measurements exhibited an extraordinarily wide
      dispersion. In both groups, weak correlations of the difference between GAT and
      IOP values with the CCT were found (correction factors of 0.95 mmHg/100 microm
      CCT at pressure level 20 mmHg, 1.2 mmHg/100 microm CCT at pressure level 30 mmHg,
      and 1.7 mmHg/100 microm CCT at pressure level 40 mmHg). CONCLUSIONS: Measurement 
      of CCT is valuable for prognostic assessment of glaucoma, but not for correction 
      factors for corneal thickness.
FAU - Kutschan, A
AU  - Kutschan A
AD  - Abteilung fur Augenheilkunde, Asklepios Klinik Nord Heidberg, Tangstedter
      Landstrasse 400, 22417 Hamburg, Deutschland. annettekutschan@gmx.de
FAU - Schroeder, B
AU  - Schroeder B
FAU - Hager, A
AU  - Hager A
FAU - Dave, H
AU  - Dave H
FAU - Wegscheider, K
AU  - Wegscheider K
FAU - Wiegand, W
AU  - Wiegand W
LA  - ger
PT  - Evaluation Study
PT  - Journal Article
TT  - Hornhautdickenabhangige Korrekturfaktoren bei der
      Goldmann-Applanationstonometrie.
PL  - Germany
TA  - Ophthalmologe
JT  - Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
JID - 9206148
SB  - IM
MH  - Aged
MH  - *Algorithms
MH  - Cataract/*diagnosis
MH  - Diagnosis, Computer-Assisted/*methods
MH  - Female
MH  - Glaucoma/*diagnosis
MH  - Humans
MH  - Male
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Tonometry, Ocular/*methods
EDAT- 2009/06/10 09:00
MHDA- 2010/04/17 06:00
CRDT- 2009/06/10 09:00
PHST- 2009/06/10 09:00 [entrez]
PHST- 2009/06/10 09:00 [pubmed]
PHST- 2010/04/17 06:00 [medline]
AID - 10.1007/s00347-009-1926-0 [doi]
PST - ppublish
SO  - Ophthalmologe. 2010 Jan;107(1):30-5. doi: 10.1007/s00347-009-1926-0.


PMID- 19504353
OWN - NLM
STAT- MEDLINE
DCOM- 20100524
LR  - 20211020
IS  - 1433-7339 (Electronic)
IS  - 0941-4355 (Linking)
VI  - 18
IP  - 4
DP  - 2010 Apr
TI  - Ways of talking about illness and prognosis in palliative cancer care
      consultations--two interactional frames.
PG  - 399-408
LID - 10.1007/s00520-009-0673-8 [doi]
AB  - GOALS OF WORK: The purpose of the study was to describe how interaction about
      changes in illness and prognosis was shaped by participants in outpatient
      palliative cancer care consultations. PATIENTS AND METHODS: The data collection
      involved six video-recorded consultations at an outpatient oncology unit at a
      university hospital in Sweden. The interactions were studied by means of
      discourse analysis. Inclusion criteria for the patients were gastro-intestinal
      cancer and receiving palliative care. The sample included three men and three
      women, aged 54-70, with various metastasised gastro-intestinal tumours.
      Significant others (SOs) were included where patients brought one to the
      consultation. Three male consultants aged 55-59 participated. MAIN RESULTS: In
      palliative care consultations, the person-to-person and the patient-professional 
      conversation frames were found to be in use as patients, SOs and physicians
      talked about the patients' illness and prognosis. Within the patient-professional
      frame, three interactional patterns were found: the patient emphasising emotional
      experiences of illness or well-being and the physicians responding by toning down
      strategies, patients asking direct questions and getting straight answers and
      finally interaction marked by cautiousness and avoidances. Within the
      person-person frame, the interactions were described as: playful talk, collegial 
      talk and existential talk. CONCLUSIONS: When patients shared their personal
      interpretations of illness and prognosis, their narrative was more enhanced by
      the person-to-person frame than the patient-professional frame. Finding out if
      and how patients and SOs want to express their worries and finding a balance
      between the interactional patterns that occur are ethical challenges which health
      professionals must face. Since patients and SOs may restrain their emotional
      experiences, investigating grounded ways of overcoming these difficulties is
      imperative.
FAU - Liden, Eva
AU  - Liden E
AD  - University College of Boras, School of Health Sciences, Allegatan 1, Boras 50190,
      Sweden. eva.liden@gu.se
FAU - Ohlen, Joakim
AU  - Ohlen J
FAU - Hyden, Lars-Christer
AU  - Hyden LC
FAU - Friberg, Febe
AU  - Friberg F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090609
PL  - Germany
TA  - Support Care Cancer
JT  - Supportive care in cancer : official journal of the Multinational Association of 
      Supportive Care in Cancer
JID - 9302957
SB  - IM
MH  - Aged
MH  - Ambulatory Care/ethics/methods
MH  - Data Collection
MH  - Female
MH  - Gastrointestinal Neoplasms/pathology/*psychology/therapy
MH  - Hospitals, University
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Metastasis
MH  - Palliative Care/ethics/*methods
MH  - *Physician-Patient Relations/ethics
MH  - Prognosis
MH  - *Referral and Consultation/ethics
MH  - Sweden
MH  - Video Recording
EDAT- 2009/06/09 09:00
MHDA- 2010/05/25 06:00
CRDT- 2009/06/09 09:00
PHST- 2008/11/03 00:00 [received]
PHST- 2009/05/25 00:00 [accepted]
PHST- 2009/06/09 09:00 [entrez]
PHST- 2009/06/09 09:00 [pubmed]
PHST- 2010/05/25 06:00 [medline]
AID - 10.1007/s00520-009-0673-8 [doi]
PST - ppublish
SO  - Support Care Cancer. 2010 Apr;18(4):399-408. doi: 10.1007/s00520-009-0673-8. Epub
      2009 Jun 9.


PMID- 19489680
OWN - NLM
STAT- MEDLINE
DCOM- 20100729
LR  - 20100126
IS  - 1557-9034 (Electronic)
IS  - 1092-6429 (Linking)
VI  - 20
IP  - 1
DP  - 2010 Feb
TI  - Laparoscopic right adrenalectomy for a large ganglioneuroma in a 12-year-old.
PG  - 95-6
LID - 10.1089/lap.2008.0347 [doi]
AB  - INTRODUCTION: Laparoscopic adrenalectomy is well established as the standard
      technique for all indications of adrenalectomy except adrenal carcinoma; however,
      some also consider large adrenal masses a relative contraindication. We present a
      video of a laparoscopic excision of a large ganglioneuroma and right
      adrenalectomy in a 12-year-old female. METHODS: Our patient was noted to have a
      right suprarenal mass on a computed tomography scan following complaints of back 
      and abdominal pain. Upon surgical consultation, she underwent a magnetic
      resonance imaging, which showed a 7.9 x 4.4 x 5.6 cm heterogeneously enhancing
      suprarenal lesion that was either arising from or compressing the right adrenal
      gland. The patient's preoperative work-up included normal urinary metanephrines, 
      alpha-fetoprotein, and beta-HCG. After discussion with the patient and family,
      the decision was made to proceed with laparoscopic excision of the mass. RESULTS:
      The patient underwent successful laparoscopic excision of the suprarenal mass and
      right adrenalectomy and was discharged from the hospital on postoperative day 2. 
      During the procedure, retraction was achieved by using a combination of 5-mm
      grasping instruments, Endokittner dissectors (Ethicon Endosurgery Cincinnati,
      OH), and a suction irrigator to provide traction and counter traction. A flexible
      5-mm liver retractor (Mediflex; Velmed, Inc., Wexford, PA) was placed directly
      through the abdominal wall without a trocar in order to elevate the liver from
      the area of the right adrenal and retroperitoneum. This enabled us to "rotate"
      the lesion out from behind the vena cava and from along the vertebral bodies. The
      pathology revealed an 8.5 x 7.0 x 3.0 cm ganglioneuroma, with primarily neural
      and Schwann cell-type tissue with interspersed large, prominent ganglion cells,
      and a normal adrenal gland. CONCLUSIONS: As demonstrated by our video, large
      adrenal masses in the pediatric population can be successfully excised
      laparoscopically with appropriate surgeon comfort and experience.
FAU - Shah, Sohail R
AU  - Shah SR
AD  - Division of Pediatric General and Thoracic Surgery, Children's Hospital of
      Pittsburgh of UPMC, University of Pittsburgh Medical Center, Pittsburgh,
      Pennsylvania 15213, USA.
FAU - Purcell, Gretchen P
AU  - Purcell GP
FAU - Malek, Marcus M
AU  - Malek MM
FAU - Kane, Timothy D
AU  - Kane TD
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Laparoendosc Adv Surg Tech A
JT  - Journal of laparoendoscopic & advanced surgical techniques. Part A
JID - 9706293
SB  - IM
MH  - Adrenal Gland Neoplasms/pathology/*surgery
MH  - Adrenalectomy/*methods
MH  - Child
MH  - Female
MH  - Ganglioneuroma/pathology/*surgery
MH  - Humans
MH  - *Laparoscopy
GN  - NLM: Original DateCompleted: 20100519
EDAT- 2009/06/06 09:00
MHDA- 2010/05/21 06:00
CRDT- 2009/06/04 09:00
PHST- 2009/06/04 09:00 [entrez]
PHST- 2009/06/06 09:00 [pubmed]
PHST- 2010/05/21 06:00 [medline]
AID - 10.1089/lap.2008.0347 [doi]
PST - ppublish
SO  - J Laparoendosc Adv Surg Tech A. 2010 Feb;20(1):95-6. doi: 10.1089/lap.2008.0347.


PMID- 19489678
OWN - NLM
STAT- MEDLINE
DCOM- 20100729
LR  - 20100126
IS  - 1557-9034 (Electronic)
IS  - 1092-6429 (Linking)
VI  - 20
IP  - 1
DP  - 2010 Feb
TI  - Laparoscopic pediatric inguinal hernia repair: no ligation, just resection.
PG  - 77-80
LID - 10.1089/lap.2008.0329 [doi]
AB  - BACKGROUND: There have been descriptions of several techniques for congenital
      inguinal hernia (CIH) repair in the pediatric population by doing high ligation
      of the sac, without a definitive advantage over the open procedure. High
      recurrence rates have been reported with using these minimally invasive
      techniques in which the patent processus vaginalis has been ligated and left in
      place completely or partially. METHODS: With approval of the ethics committee, a 
      proper informed consent was obtained. During July 2003 to April 2008, we
      performed the inguinal hernia repair on 91 patients (76 males and 15 females),
      using a laparoscopic technique in which we completely resected the patent
      processus vaginalis and the parietal peritoneum surrounding the internal inguinal
      ring. This allowed the peritoneal scar tissue to close the area of the ring.
      Also, this scarring occurs in the extent of the inguinal canal where the
      dissection took place, therefore causing the same peritoneal scarring and sealing
      of the inguinal floor. In this series, a purse string was done only in the cases 
      with an internal ring wider than 10 mm. RESULTS: There were no conversions.
      Operative time was in the range of 35-72 minutes (average, 40). Close follow-up
      in the clinic has been 5 months to 4 years without a single recurrence. In 4
      cases, 3 months later, we did a laparoscopic evaluation of the contralateral side
      due to associated cryptorchidism, in which we were able to confirm a complete
      closure of the interior inguinal ring. Two small hematomas were followed until
      they were gone, without further need for intervention. DISCUSSION: No recurrences
      have been observed. We conclude that laparoscopic repair of CIH is feasible using
      this technique of complete resection of the processus vaginalis and surrounding
      parietal peritoneum. This series does not conclude on the need for the internal
      ring to be closed when found to be wider than 10 mm.
FAU - Riquelme, Mario
AU  - Riquelme M
AD  - Department of General and Pediatric Surgery, Christus Muguerza Hospital,
      University of Monterrey, Monterrey, Mexico. cima_riquelme@hotmail.com
FAU - Aranda, Arturo
AU  - Aranda A
FAU - Riquelme-Q, Mario
AU  - Riquelme-Q M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Laparoendosc Adv Surg Tech A
JT  - Journal of laparoendoscopic & advanced surgical techniques. Part A
JID - 9706293
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Hernia, Inguinal/*surgery
MH  - Humans
MH  - Infant
MH  - *Laparoscopy/methods
MH  - Male
GN  - NLM: Original DateCompleted: 20100519
EDAT- 2009/06/06 09:00
MHDA- 2010/05/21 06:00
CRDT- 2009/06/04 09:00
PHST- 2009/06/04 09:00 [entrez]
PHST- 2009/06/06 09:00 [pubmed]
PHST- 2010/05/21 06:00 [medline]
AID - 10.1089/lap.2008.0329 [doi]
PST - ppublish
SO  - J Laparoendosc Adv Surg Tech A. 2010 Feb;20(1):77-80. doi: 10.1089/lap.2008.0329.


PMID- 19488835
OWN - NLM
STAT- MEDLINE
DCOM- 20100603
LR  - 20211020
IS  - 1573-7292 (Electronic)
IS  - 1389-9600 (Linking)
VI  - 9
IP  - 1
DP  - 2010 Mar
TI  - Health-related direct-to-consumer genetic testing: a review of companies'
      policies with regard to genetic testing in minors.
PG  - 51-9
LID - 10.1007/s10689-009-9253-9 [doi]
AB  - More and more companies are advertising and selling genetic tests directly to
      consumers. Considering the ethical, legal, and psychological concerns surrounding
      genetic testing in minors, a study of companies' websites was performed in order 
      to describe and analyze their policies with respect to this issue. Of the 29
      companies analyzed, 13 did not provide any information about this matter, eight
      companies allowed genetic testing upon parental request, four companies stated
      that their website is not directed to children under 18 years, and four companies
      suggested that in order to be tested, applicants should have reached the age of
      legal majority. If private companies offer genetic tests which are also offered
      in a clinical setting, can they be expected to adhere to the existing clinical
      guidelines with regard to these tests? If so, a certain ambiguity exists. Many
      companies are emphasizing in their disclaimers that their services are not
      medical services and should not be used as a basis for making medical decisions. 
      Nonetheless, it remains debatable whether genetic testing in minors would be
      appropriate in this context. In line with the Advisory Committee on Genetic
      Testing, the Human Genetics Commission addressed the problem of non-consensual
      testing and recommended not to supply genetic testing services directly to those 
      under the age of 16 or to those not able to make a competent decision regarding
      testing.
FAU - Borry, Pascal
AU  - Borry P
AD  - Centre for Biomedical Ethics and Law, Katholieke Universiteit Leuven,
      Kapucijnenvoer 35, Box 7001, 3000, Leuven, Belgium. Pascal.Borry@med.kuleuven.be
FAU - Howard, Heidi C
AU  - Howard HC
FAU - Senecal, Karine
AU  - Senecal K
FAU - Avard, Denise
AU  - Avard D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090602
PL  - Netherlands
TA  - Fam Cancer
JT  - Familial cancer
JID - 100898211
SB  - IM
MH  - Child
MH  - Confidentiality/*legislation & jurisprudence
MH  - Ethics, Medical
MH  - Genetic Counseling/*legislation & jurisprudence
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genetic Privacy/legislation & jurisprudence
MH  - Genetic Services/standards
MH  - Genetic Testing/*methods
MH  - Genetics, Medical/education
MH  - Government Regulation
MH  - Guidelines as Topic
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Marketing of Health Services/ethics
MH  - Minors
MH  - Physician's Role
MH  - Practice Guidelines as Topic
MH  - Truth Disclosure/ethics
EDAT- 2009/06/03 09:00
MHDA- 2010/06/04 06:00
CRDT- 2009/06/03 09:00
PHST- 2009/01/15 00:00 [received]
PHST- 2009/05/20 00:00 [accepted]
PHST- 2009/06/03 09:00 [entrez]
PHST- 2009/06/03 09:00 [pubmed]
PHST- 2010/06/04 06:00 [medline]
AID - 10.1007/s10689-009-9253-9 [doi]
PST - ppublish
SO  - Fam Cancer. 2010 Mar;9(1):51-9. doi: 10.1007/s10689-009-9253-9. Epub 2009 Jun 2.


PMID- 19487094
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20161125
IS  - 1872-7727 (Electronic)
IS  - 0720-048X (Linking)
VI  - 76
IP  - 1
DP  - 2010 Oct
TI  - Comparison of tissue equalization, and premium view post-processing methods in
      full field digital mammography.
PG  - 73-80
LID - 10.1016/j.ejrad.2009.05.010 [doi]
AB  - OBJECTIVE: To retrospectively evaluate the diagnostic abilities of 2
      post-processing methods provided by GE Senographe DS system, tissue equalization 
      (TE) and premium view (PV) in full field digital mammography (FFDM). MATERIALS
      AND METHODS: In accordance with the ethical standards of the World Medical
      Association, this study was approved by regional ethics committee and signed
      informed patient consents were obtained. We retrospectively reviewed digital
      mammograms from 101 women (mean age, 47 years; range, 23-81 years) in the modes
      of TE and PV, respectively. Three radiologists, fully blinded to the
      post-processing methods, all patient clinical information and histologic results,
      read images by using objective image interpretation criteria for diagnostic
      information end points such as lesion border delineation, definition of disease
      extent, visualization of internal and surrounding morphologic features of the
      lesions. Also, overall diagnostic impression in terms of lesion conspicuity,
      detectability and diagnostic confidence was assessed. Between-group comparisons
      were performed with Wilcoxon signed rank test. RESULTS: Readers 1, 2, and 3
      demonstrated significant overall better impression of PV in 29, 27, and 24
      patients, compared with that for TE in 12, 13, and 11 patients, respectively
      (p<0.05). Significant (p<0.05) better impression of PV was also demonstrated for 
      diagnostic information end points. Importantly, PV proved to be more sensitive
      than TE while detecting malignant lesions in dense breast rather than benign
      lesions and malignancy in non-dense breast (p<0.01). CONCLUSION: PV compared with
      TE provides marked better diagnostic information in FFDM, particularly for
      patients with malignancy in dense breast.
CI  - Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
FAU - Chen, Baoying
AU  - Chen B
AD  - Department of Radiology, Tangdu Hospital, Fourth Military Medical University,
      Xi'an, Shaanxi, China. chenby128@yahoo.com
FAU - Wang, Wei
AU  - Wang W
FAU - Huang, Jin
AU  - Huang J
FAU - Zhao, Ming
AU  - Zhao M
FAU - Cui, Guangbin
AU  - Cui G
FAU - Xu, Jing
AU  - Xu J
FAU - Guo, Wei
AU  - Guo W
FAU - Du, Pang
AU  - Du P
FAU - Li, Pei
AU  - Li P
FAU - Yu, Jun
AU  - Yu J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090531
PL  - Ireland
TA  - Eur J Radiol
JT  - European journal of radiology
JID - 8106411
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Breast Neoplasms/*diagnostic imaging
MH  - Female
MH  - Humans
MH  - Mammography/*methods
MH  - Middle Aged
MH  - Radiographic Image Interpretation, Computer-Assisted/*methods
MH  - Retrospective Studies
MH  - Statistics, Nonparametric
EDAT- 2009/06/03 09:00
MHDA- 2011/02/25 06:00
CRDT- 2009/06/03 09:00
PHST- 2009/03/23 00:00 [received]
PHST- 2009/05/06 00:00 [revised]
PHST- 2009/05/07 00:00 [accepted]
PHST- 2009/06/03 09:00 [entrez]
PHST- 2009/06/03 09:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - S0720-048X(09)00290-3 [pii]
AID - 10.1016/j.ejrad.2009.05.010 [doi]
PST - ppublish
SO  - Eur J Radiol. 2010 Oct;76(1):73-80. doi: 10.1016/j.ejrad.2009.05.010. Epub 2009
      May 31.


PMID- 19486094
OWN - NLM
STAT- MEDLINE
DCOM- 20110405
LR  - 20161125
IS  - 1463-1318 (Electronic)
IS  - 1462-8910 (Linking)
VI  - 12
IP  - 7
DP  - 2010 Jul
TI  - The impact of national guidelines on the waiting list for colonoscopy: a
      quantitative clinical audit.
PG  - 632-9
LID - 10.1111/j.1463-1318.2009.01871.x [doi]
AB  - OBJECTIVE: To assess the compliance of the surveillance colonoscopy waiting list 
      with ACPGBI/BSG guidelines for colonoscopy follow-up and to measure the impact of
      adjusting referrals to be inline with the guidelines. DESIGN AND SETTING: This is
      a quantitative five-stage clinical audit cycle involving a large patient cohort
      from the Kent and Medway Cancer Network, which includes seven hospitals across
      four NHS Hospital Trusts and an estimated population of 1.8 million.
      PARTICIPANTS: 3020 patients were waiting for a surveillance colonoscopy. Their
      notes were reviewed and the indications for colonoscopy were compared with the
      ACPGBI/BSG 2002 guidelines. INTERVENTIONS: Those patients whose referral to the
      surveillance colonoscopy waiting list was not found to be compliant were adjusted
      to be inline with the guidelines. MAIN OUTCOME MEASURES: The impact of adjusting 
      the surveillance colonoscopy waiting list on the diagnostic colonoscopy service
      was assessed by measuring the average waiting times for a colonoscopy before and 
      after the intervention. RESULTS: Around 22% (n = 664) of surveillance colonoscopy
      referrals were inline with the guidelines, 51% (n = 1540) could be cancelled from
      the list and 27% (n = 816) could be given a new date. Implementing these
      recommendations reduced the average wait for a diagnostic colonoscopy from 76.8
      to 56.0 days (P = 0.0022). CONCLUSION: Following guidelines for surveillance
      colonoscopy can reduce waiting times for diagnostic colonoscopy. This allows a
      faster patient journey for diagnostic colonoscopy and a uniform plan for duration
      and frequency of surveillance colonoscopy. However, this action promoted serious 
      debate on the social, moral and ethical issues.
FAU - Chivers, K
AU  - Chivers K
AD  - School of Health Sciences, University of Southampton, University Road, Highfield,
      Southampton, UK. kimchivers@hotmail.com
FAU - Basnyat, P
AU  - Basnyat P
FAU - Taffinder, N
AU  - Taffinder N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090410
PL  - England
TA  - Colorectal Dis
JT  - Colorectal disease : the official journal of the Association of Coloproctology of
      Great Britain and Ireland
JID - 100883611
SB  - IM
CIN - Colorectal Dis. 2010 Jul;12(7):639-41. PMID: 20642596
MH  - *Colonoscopy
MH  - Colorectal Neoplasms/*diagnosis
MH  - *Guideline Adherence
MH  - *Guidelines as Topic
MH  - Humans
MH  - Patient Compliance/*statistics & numerical data
MH  - United Kingdom
MH  - *Waiting Lists
EDAT- 2009/06/03 09:00
MHDA- 2011/04/06 06:00
CRDT- 2009/06/03 09:00
PHST- 2009/06/03 09:00 [entrez]
PHST- 2009/06/03 09:00 [pubmed]
PHST- 2011/04/06 06:00 [medline]
AID - CDI1871 [pii]
AID - 10.1111/j.1463-1318.2009.01871.x [doi]
PST - ppublish
SO  - Colorectal Dis. 2010 Jul;12(7):632-9. doi: 10.1111/j.1463-1318.2009.01871.x. Epub
      2009 Apr 10.


PMID- 19482372
OWN - NLM
STAT- MEDLINE
DCOM- 20100423
LR  - 20191210
IS  - 1872-8332 (Electronic)
IS  - 0169-5002 (Linking)
VI  - 67
IP  - 3
DP  - 2010 Mar
TI  - Combined FDG-PET/CT in response evaluation of malignant pleural mesothelioma.
PG  - 311-7
LID - 10.1016/j.lungcan.2009.04.015 [doi]
AB  - PURPOSE: Based on the complex growth pattern of MPM, conventional response
      evaluation in this cancer entity is challenging. Therefore, there is growing
      interest in therapy response evaluation with FDG-PET/CT. The aim of the study was
      to evaluate the value of several FDG-PET/CT-parameters in therapy response
      evaluation concerning prediction of survival at baseline and after three cycles
      of therapy. PATIENTS AND METHODS: The study was performed in accordance with the 
      regulations of the local ethics committee. Forty-one patients with proven MPM and
      treated with palliative pemetrexed and platinum-based chemotherapy were included.
      All patients were evaluated by FDG-PET/CT at baseline and after three cycles of
      chemotherapy. Responders and non-responders were evaluated based on modified
      RECIST- and EORTC-criteria. Additional PET-parameters (SUVmean, tumor lesion
      glycolysis (TLG) and tumor volume (PETvol)) were evaluated. Results were
      evaluated using the COX regression and the Kaplan-Meier method. RESULTS: None of 
      the baseline CT-measurements or the initial PET-parameters were predictive for
      survival. Based on CT, after three cycles of therapy 10 patients were categorized
      as responders, 30 were classified as stable disease and 1 had progressive
      disease. Based on PET-evaluation, 14 responders were identified, 23 patients with
      stable disease and 4 patients were progressive. CT-response after 3 cycles of
      chemotherapy was significantly related to overall survival (p=0.001). However,
      neither SUVmax-response (p=0.61) nor SUVmean-response (p=0.68) were related to
      survival. A decrease of TLG and PETvol, however, was found to be predictive (TLG:
      p=0.01; PETvol: p=0.002). CONCLUSION: Response evaluation based on modified
      RECIST by CT as well as response evaluation by TLG and PETvol in FDG-PET, but not
      SUVmax-measurements are predictive for survival in MPM.
FAU - Veit-Haibach, Patrick
AU  - Veit-Haibach P
AD  - Department of Medical Radiology, University Hospital Zuerich, Switzerland.
FAU - Schaefer, Niklaus G
AU  - Schaefer NG
FAU - Steinert, Hans C
AU  - Steinert HC
FAU - Soyka, Jan D
AU  - Soyka JD
FAU - Seifert, Burkhardt
AU  - Seifert B
FAU - Stahel, Rolf A
AU  - Stahel RA
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090530
PL  - Ireland
TA  - Lung Cancer
JT  - Lung cancer (Amsterdam, Netherlands)
JID - 8800805
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Glutamates)
RN  - 04Q9AIZ7NO (Pemetrexed)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
RN  - 5Z93L87A1R (Guanine)
RN  - BG3F62OND5 (Carboplatin)
RN  - Q20Q21Q62J (Cisplatin)
SB  - IM
MH  - Antineoplastic Agents/*therapeutic use
MH  - Carboplatin/therapeutic use
MH  - Cisplatin/therapeutic use
MH  - Female
MH  - Fluorodeoxyglucose F18
MH  - Glutamates/therapeutic use
MH  - Glycolysis/drug effects
MH  - Guanine/analogs & derivatives/therapeutic use
MH  - Humans
MH  - Male
MH  - Mesothelioma/diagnostic imaging/drug therapy/*mortality
MH  - Palliative Care
MH  - Pemetrexed
MH  - Pleural Neoplasms/diagnostic imaging/drug therapy/*mortality
MH  - Positron-Emission Tomography
MH  - Prognosis
MH  - Treatment Outcome
EDAT- 2009/06/02 09:00
MHDA- 2010/04/24 06:00
CRDT- 2009/06/02 09:00
PHST- 2008/12/05 00:00 [received]
PHST- 2009/04/06 00:00 [revised]
PHST- 2009/04/22 00:00 [accepted]
PHST- 2009/06/02 09:00 [entrez]
PHST- 2009/06/02 09:00 [pubmed]
PHST- 2010/04/24 06:00 [medline]
AID - S0169-5002(09)00253-0 [pii]
AID - 10.1016/j.lungcan.2009.04.015 [doi]
PST - ppublish
SO  - Lung Cancer. 2010 Mar;67(3):311-7. doi: 10.1016/j.lungcan.2009.04.015. Epub 2009 
      May 30.


PMID- 19459900
OWN - NLM
STAT- MEDLINE
DCOM- 20100614
LR  - 20151119
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 10
IP  - 1
DP  - 2010 Apr
TI  - Stakeholder perspectives on ethical challenges in HIV vaccine trials in South
      Africa.
PG  - 11-21
LID - 10.1111/j.1471-8847.2009.00254.x [doi]
AB  - There is little published literature on the ethical concerns of stakeholders in
      HIV vaccine trials. This study explored the ethical challenges identified by
      various stakeholders, through an open-ended, in-depth approach. While the few
      previous studies have been largely quantitative, respondents in this study had
      the opportunity to spontaneously identify the issues that they perceived to be of
      priority concern in the South African context. Stakeholders spontaneously
      identified the following as ethical priorities: informed consent, social harms,
      collaborative relationships between research stakeholders, the participation of
      children and adolescents, access to treatment for participants who become
      infected with HIV, physical harms, fair participant and community selection,
      confidentiality, benefits, and payment. While there is some speculation that
      research in developing countries poses special ethical challenges, overall no
      issues were identified that have not been anticipated in international guidance, 
      literature and popular frameworks. However, the South African context affords a
      distinctive gloss to these expected issues; for example, respondents were
      concerned that the predominant selection of black participants may perpetuate
      racist practices of apartheid. Stakeholders should be aware of contextual factors
      impacting on the implementation of ethical principles. We make a series of
      recommendations for South African trials, including amendments to the
      ethical-legal framework and research policies, and, for further research.
FAU - Essack, Zaynab
AU  - Essack Z
AD  - University of KwaZulu-Natal. essack@ukzn.ac.za
FAU - Koen, Jennifer
AU  - Koen J
FAU - Barsdorf, Nicola
AU  - Barsdorf N
FAU - Slack, Catherine
AU  - Slack C
FAU - Quayle, Michael
AU  - Quayle M
FAU - Milford, Cedilia
AU  - Milford C
FAU - Lindegger, Graham
AU  - Lindegger G
FAU - Ranchod, Chitra
AU  - Ranchod C
FAU - Mukuka, Richard
AU  - Mukuka R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
RN  - 0 (AIDS Vaccines)
SB  - IM
MH  - AIDS Vaccines/*administration & dosage
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Clinical Trials as Topic/*ethics
MH  - Confidentiality/ethics
MH  - Developing Countries
MH  - Ethics Committees, Research
MH  - Ethics, Research
MH  - Female
MH  - HIV Infections/*prevention & control
MH  - Health Services Accessibility/*ethics
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Male
MH  - Patient Selection/ethics
MH  - Prejudice
MH  - Research Design
MH  - Research Personnel/economics/*ethics
MH  - Research Subjects/economics
MH  - South Africa
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2009/05/23 09:00
MHDA- 2010/06/15 06:00
CRDT- 2009/05/23 09:00
PHST- 2009/05/23 09:00 [entrez]
PHST- 2009/05/23 09:00 [pubmed]
PHST- 2010/06/15 06:00 [medline]
AID - DEWB254 [pii]
AID - 10.1111/j.1471-8847.2009.00254.x [doi]
PST - ppublish
SO  - Dev World Bioeth. 2010 Apr;10(1):11-21. doi: 10.1111/j.1471-8847.2009.00254.x.


PMID- 19459899
OWN - NLM
STAT- MEDLINE
DCOM- 20100614
LR  - 20100505
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 10
IP  - 1
DP  - 2010 Apr
TI  - Reflection on euthanasia: Western and African Ntomba perspectives on the death of
      a chief.
PG  - 42-8
LID - 10.1111/j.1471-8847.2009.00255.x [doi]
AB  - Largely, the concept of energy or vital force, as first analysed by Placide
      Tempels in Bantu Philosophy, permeates most African ontology systems, worldviews 
      and life views. The Ntomba Chief is chosen because of his above average vital
      force. This puts him in the position of intermediary between the Supreme Being,
      the ancestors, and his subordinates. The waning of his energy is incompatible
      with his position because his energy is that of his tribe. When installed, he
      takes an oath that, when this happens, he has to accept mohilo, the 'hastening of
      death'. In the Chief's case, the hastening of death is not intended to relieve
      his pain, as it would be with other creatures. The Chief's dying a natural death 
      would result in the loss of the entire community's vital force. Therefore, he has
      to be killed ritually to avoid that risk. That the Chief agrees to be killed -
      via a form of advanced directive - poses an ethical dilemma for a Western
      observer. From the Ntomba perspective, however, where the energy is being, and
      being is energy, it is the only way to preserve and protect the community's
      raison d'etre.
FAU - Bikopo, Deogratias Biembe
AU  - Bikopo DB
AD  - University of the Witwatersrand, South Africa. ljfvanbo@lantic.net
FAU - Van Bogaert, Louis-Jacques
AU  - Van Bogaert LJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
SB  - IM
MH  - Africa
MH  - Attitude to Death/*ethnology
MH  - *Cultural Characteristics
MH  - Euthanasia, Active/*ethics
MH  - *Homicide
MH  - Humans
MH  - *Philosophy
EDAT- 2009/05/23 09:00
MHDA- 2010/06/15 06:00
CRDT- 2009/05/23 09:00
PHST- 2009/05/23 09:00 [entrez]
PHST- 2009/05/23 09:00 [pubmed]
PHST- 2010/06/15 06:00 [medline]
AID - DEWB255 [pii]
AID - 10.1111/j.1471-8847.2009.00255.x [doi]
PST - ppublish
SO  - Dev World Bioeth. 2010 Apr;10(1):42-8. doi: 10.1111/j.1471-8847.2009.00255.x.


PMID- 19446015
OWN - NLM
STAT- MEDLINE
DCOM- 20100315
LR  - 20100201
IS  - 1879-3169 (Electronic)
IS  - 0378-4274 (Linking)
VI  - 192
IP  - 1
DP  - 2010 Jan 15
TI  - Biomonitoring for occupational health risk assessment (BOHRA).
PG  - 3-16
LID - 10.1016/j.toxlet.2009.05.001 [doi]
AB  - Biological monitoring (BM or biomonitoring) deals with the assessment of
      individual human exposure, effect and susceptibility to occupational risk
      factors. It is a fundamental tool in occupational health risk assessment (OHRA)
      and occupational health practice (OHP) and it has become one of the most, if not 
      the most active area in occupational health (OH) research today. From the few
      hundred BM papers published in the 80s, there are now several tens of thousand
      papers published in the peer review literature each year, and the trend is still 
      rising exponentially. As a result, BM has become a priority for the Scientific
      Committee on Occupational Toxicology (SCOT) of the International Commission on
      Occupational Health (ICOH). Moreover, there has been a long-term interest in
      biological monitoring by other SCs of ICOH such as the Scientific Committees on
      Toxicology of Metals (SCTM) and on Rural Health (SCRH). Despite its current
      popularity, though, BM is not always correctly used or interpreted by those
      involved in OHRA or OHP. The present review has been prepared to fill this gap
      and to help preventing misuse and misinterpretation of data. Although the
      document is meant to be a reference primarily for those involved in OH research
      and/or practice, it might become of interest for a wider audience within and
      outside ICOH, including scientists, occupational physicians, industrial
      hygienists and occupational or public health professionals in general, involved
      in chemical risk assessment for occupational health. The mission of SCOT and also
      of other SCs of ICOH, such as SCTM and SCRH, is indeed to promote the advancement
      and diffusion of knowledge on biological monitoring and other relevant
      occupational toxicology aspects and to make them available and useful to the
      entire OH scientific community. All articles retrieved as of 3 January, 2007 as
      "Review" with the combined key words "biological monitoring" in PubMed from 2000 
      to 2007 have been scanned individually. This yielded a total of 1400 articles
      from a grand total of 2486 (excluding limitation on year of publication). When
      the title was related to human occupational biological monitoring, the abstract
      was read and its content was included. Articles outside the 2000-2007 time frame 
      or that are not classified as "Review" in PubMed have also been included, when
      relevant. The review is in four parts: (a) the introduction, containing the basic
      principles and definitions of BM and the different types of biomarkers (BMK),
      their toxicological significance, practical use and limitations, (b) the
      methodological and analytical aspects of BM in exposed workers, (c) the
      interpretation and management of BM data, including a number of recommendations
      to be considered when planning, performing and interpreting BM results and,
      finally, (d) the ethical aspects of BM. A list of key references to relevant
      papers or documents has been included. The BM of specific chemicals or groups of 
      chemicals is outside the purpose of the review. The document is aimed to
      represent the state of the art on biological monitoring in occupational risk
      assessment. We expect that reference to its content will be made, whenever
      appropriate, by those involved in occupational health practice and research when 
      dealing with BM issues. The document is not meant, though, to represent a rigid
      nor a permanent set of rules and it will be periodically updated according to new
      developments and any significant advance in BM science. Any part of the document,
      therefore, is open to suggestions by scientifically qualified persons or
      institutions officially involved in BM and comments should be sent directly to
      the authors. A preliminary draft of the document has been presented at the 7th
      International Symposium on Biological Monitoring, Beijing, 10-12 September, 2007.
CI  - Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
FAU - Manno, Maurizio
AU  - Manno M
AD  - Department of Preventive Medical Sciences, University of Naples Federico II, Via 
      S. Pansini, 5, 80131 Naples, Italy. maurizio.manno@unina.it
FAU - Viau, Claude
AU  - Viau C
CN  - in collaboration with
FAU - Cocker, John
AU  - Cocker J
FAU - Colosio, Claudio
AU  - Colosio C
FAU - Lowry, Larry
AU  - Lowry L
FAU - Mutti, Antonio
AU  - Mutti A
FAU - Nordberg, Monica
AU  - Nordberg M
FAU - Wang, Sheng
AU  - Wang S
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20090513
PL  - Netherlands
TA  - Toxicol Lett
JT  - Toxicology letters
JID - 7709027
SB  - IM
MH  - Data Interpretation, Statistical
MH  - Ecotoxicology
MH  - Environmental Monitoring/*methods
MH  - Humans
MH  - Occupational Exposure/*analysis
MH  - Occupational Health
MH  - Public Health
MH  - Risk Assessment/*methods
RF  - 71
EDAT- 2009/05/19 09:00
MHDA- 2010/03/17 06:00
CRDT- 2009/05/19 09:00
PHST- 2009/04/30 00:00 [received]
PHST- 2009/05/04 00:00 [accepted]
PHST- 2009/05/19 09:00 [entrez]
PHST- 2009/05/19 09:00 [pubmed]
PHST- 2010/03/17 06:00 [medline]
AID - S0378-4274(09)00248-3 [pii]
AID - 10.1016/j.toxlet.2009.05.001 [doi]
PST - ppublish
SO  - Toxicol Lett. 2010 Jan 15;192(1):3-16. doi: 10.1016/j.toxlet.2009.05.001. Epub
      2009 May 13.


PMID- 19444903
OWN - NLM
STAT- MEDLINE
DCOM- 20100630
LR  - 20100408
IS  - 1098-108X (Electronic)
IS  - 0276-3478 (Linking)
VI  - 43
IP  - 4
DP  - 2010 May
TI  - Medical futility and psychiatry: palliative care and hospice care as a last
      resort in the treatment of refractory anorexia nervosa.
PG  - 372-7
LID - 10.1002/eat.20701 [doi]
AB  - OBJECTIVE: The concept of medical futility is accepted in general medicine, yet
      little attention has been paid to its application in psychiatry. We explore how
      medical futility and principles of palliation may contribute to the management of
      treatment refractory anorexia nervosa. METHOD: We review the case of a
      30-year-old woman with chronic anorexia nervosa, treated unsuccessfully for
      several years. RESULTS: Ongoing assessment, including ethical consultation,
      determined that further active treatment was unlikely to resolve her condition.
      The patient was referred for palliative care and hospice care, and ultimately
      died. DISCUSSION: Although circumstances requiring its use are rare, palliative
      care may play a role in the treatment of long suffering, treatment refractory
      patients. For poor prognosis patients who are unresponsive to competent
      treatment, continue to decline physiologically and psychologically, and appear to
      face an inexorably terminal course, palliative care and hospice may be a humane
      alternative.
CI  - 2009 by Wiley Periodicals, Inc.
FAU - Lopez, Amy
AU  - Lopez A
AD  - Department of Psychiatry, University of Colorado, Denver, Colorado, USA.
      amy.lopez@uch.edu
FAU - Yager, Joel
AU  - Yager J
FAU - Feinstein, Robert E
AU  - Feinstein RE
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Int J Eat Disord
JT  - The International journal of eating disorders
JID - 8111226
SB  - IM
MH  - Adult
MH  - Anorexia Nervosa/*psychology/*therapy
MH  - Body Mass Index
MH  - Chronic Disease/psychology
MH  - Colorado
MH  - Ethics, Medical
MH  - Exercise/psychology
MH  - Female
MH  - Hospice Care/ethics/*psychology
MH  - Humans
MH  - Medical Futility/ethics/*psychology
MH  - Obsessive-Compulsive Disorder/psychology/therapy
MH  - Palliative Care/ethics/*psychology
MH  - Patient Care Team
MH  - Referral and Consultation/ethics
MH  - Treatment Refusal/ethics/psychology
EDAT- 2009/05/16 09:00
MHDA- 2010/07/01 06:00
CRDT- 2009/05/16 09:00
PHST- 2009/05/16 09:00 [entrez]
PHST- 2009/05/16 09:00 [pubmed]
PHST- 2010/07/01 06:00 [medline]
AID - 10.1002/eat.20701 [doi]
PST - ppublish
SO  - Int J Eat Disord. 2010 May;43(4):372-7. doi: 10.1002/eat.20701.


PMID- 19444123
OWN - NLM
STAT- MEDLINE
DCOM- 20100222
LR  - 20131121
IS  - 1365-2346 (Electronic)
IS  - 0265-0215 (Linking)
VI  - 27
IP  - 1
DP  - 2010 Jan
TI  - Laryngeal mask airway vs. uncuffed endotracheal tube for nasal and paranasal
      sinus surgery: paediatric airway protection.
PG  - 16-9
LID - 10.1097/EJA.0b013e32832c5f09 [doi]
AB  - BACKGROUND AND OBJECTIVE: Risks are anticipated for laryngeal mask airway (LMA)
      anaesthesia during nasal and sinus surgeries because blood can trickle
      posteriorly into the hypopharynx and contaminate the airway. This study was
      conducted to determine whether a LMA could provide adequate airway protection
      from the expected intraoperative bleeding. METHODS: After obtaining ethics
      committee approval, 60 children ASA status I or II, 1-12 years of age, and
      scheduled for nasal and sinus surgery were randomized to one of two groups,
      endotracheal tube (ETT) or LMA, with 30 patients in each. Topical lidocaine with 
      adrenaline was used in all patients, and throat packs were used for the ETT
      group. The airway was examined using a fibreoptic endoscope in order to determine
      whether blood or tissue debris soiled the supraglottic airway or trachea. After
      extubation, LMAs and ETTs were examined for soiling by blood and graded on a
      scale of 0-3. For ETT, the grades were 0, none; 1, contamination above the mark
      for vocal cord depth; 2, contamination below the mark for vocal cord depth; and
      3, contamination interiorly. For LMA, they were 0, no staining; 1, staining on
      the anterior aspect of the cuff of the LMA; 2, staining inside the cup of the
      LMA; and 3, staining found in the tube. RESULTS: Blood stains were found in the
      larynx of one child in the LMA group. In the ETT group, there were three cases of
      staining (two supraglottic and one in the trachea, P = 0.161). With the LMA, 12
      (40%) and 18 (60%) patients had visual contamination scores of 0 and 1,
      respectively. With the ETT, 14 (46.7%), 10 (33.3%), and six (20%) patients had
      visual contamination scores of 0, 1, and 2, respectively (P = 0.0123).
      CONCLUSION: LMA is a suitable method for paediatric patients undergoing sinonasal
      surgery because it offers airway protection from blood contamination comparable
      to that of a standard uncuffed ETT with throat pack.
FAU - Al-Mazrou, Khalid A
AU  - Al-Mazrou KA
AD  - Division of Pediatric Otolaryngology, King Abdul-Aziz University Hospital, King
      Saud University, Riyadh, Saudi Arabia.
FAU - Abdullah, Khalid M
AU  - Abdullah KM
FAU - ElGammal, Mohamed S
AU  - ElGammal MS
FAU - Ansari, Riaz A
AU  - Ansari RA
FAU - Turkistani, Ahmed
AU  - Turkistani A
FAU - Abdelmeguid, Mohamed E
AU  - Abdelmeguid ME
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - Eur J Anaesthesiol
JT  - European journal of anaesthesiology
JID - 8411711
RN  - 98PI200987 (Lidocaine)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Endoscopy/methods
MH  - Epinephrine/administration & dosage
MH  - Fiber Optic Technology
MH  - Humans
MH  - Hypopharynx/pathology
MH  - Infant
MH  - Intubation, Intratracheal/*instrumentation
MH  - *Laryngeal Masks
MH  - Lidocaine/administration & dosage
MH  - Nose/*surgery
MH  - Paranasal Sinuses/*surgery
MH  - Risk
MH  - Trachea/pathology
EDAT- 2009/05/16 09:00
MHDA- 2010/02/23 06:00
CRDT- 2009/05/16 09:00
PHST- 2009/05/16 09:00 [entrez]
PHST- 2009/05/16 09:00 [pubmed]
PHST- 2010/02/23 06:00 [medline]
AID - 10.1097/EJA.0b013e32832c5f09 [doi]
PST - ppublish
SO  - Eur J Anaesthesiol. 2010 Jan;27(1):16-9. doi: 10.1097/EJA.0b013e32832c5f09.


PMID- 19438441
OWN - NLM
STAT- MEDLINE
DCOM- 20110310
LR  - 20101029
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 24
IP  - 9
DP  - 2010 Nov
TI  - Reflective equilibrium and empirical data: third person moral experiences in
      empirical medical ethics.
PG  - 490-8
LID - 10.1111/j.1467-8519.2009.01721.x [doi]
AB  - In ethics, the use of empirical data has become more and more popular, leading to
      a distinct form of applied ethics, namely empirical ethics. This 'empirical turn'
      is especially visible in bioethics. There are various ways of combining empirical
      research and ethical reflection. In this paper we discuss the use of empirical
      data in a special form of Reflective Equilibrium (RE), namely the Network Model
      with Third Person Moral Experiences. In this model, the empirical data consist of
      the moral experiences of people in a practice. Although inclusion of these moral 
      experiences in this specific model of RE can be well defended, their use in the
      application of the model still raises important questions. What precisely are
      moral experiences? How to determine relevance of experiences, in other words:
      should there be a selection of the moral experiences that are eventually used in 
      the RE? How much weight should the empirical data have in the RE? And the key
      question: can the use of RE by empirical ethicists really produce answers to
      practical moral questions? In this paper we start to answer the above questions
      by giving examples taken from our research project on understanding the norm of
      informed consent in the field of pediatric oncology. We especially emphasize that
      incorporation of empirical data in a network model can reduce the risk of
      self-justification and bias and can increase the credibility of the RE reached.
CI  - (c) 2009 Blackwell Publishing Ltd.
FAU - De Vries, Martine
AU  - De Vries M
AD  - Department of Medical Ethics and Health Law, Leiden University Medical Center,
      The Netherlands. m.c.de_vries@lumc.nl
FAU - Van Leeuwen, Evert
AU  - Van Leeuwen E
LA  - eng
PT  - Journal Article
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Adolescent
MH  - Child
MH  - *Empirical Research
MH  - *Ethics, Medical
MH  - Humans
MH  - Informed Consent/*ethics/legislation & jurisprudence
MH  - *Intuition
MH  - Models, Theoretical
MH  - *Morals
MH  - Neoplasms/therapy
MH  - Netherlands
MH  - Parental Consent/ethics
MH  - Patient Participation
MH  - Pediatrics/ethics
EDAT- 2009/05/15 09:00
MHDA- 2011/03/11 06:00
CRDT- 2009/05/15 09:00
PHST- 2009/05/15 09:00 [entrez]
PHST- 2009/05/15 09:00 [pubmed]
PHST- 2011/03/11 06:00 [medline]
AID - BIOT1721 [pii]
AID - 10.1111/j.1467-8519.2009.01721.x [doi]
PST - ppublish
SO  - Bioethics. 2010 Nov;24(9):490-8. doi: 10.1111/j.1467-8519.2009.01721.x.


PMID- 19432769
OWN - NLM
STAT- MEDLINE
DCOM- 20100924
LR  - 20211020
IS  - 1541-0420 (Electronic)
IS  - 0006-341X (Linking)
VI  - 66
IP  - 1
DP  - 2010 Mar
TI  - Determination of sample sizes for demonstrating efficacy of radiation
      countermeasures.
PG  - 239-48
LID - 10.1111/j.1541-0420.2009.01236.x [doi]
AB  - In response to the ever increasing threat of radiological and nuclear terrorism, 
      active development of nontoxic new drugs and other countermeasures to protect
      against and/or mitigate adverse health effects of radiation is ongoing. Although 
      the classical LD(50) study used for many decades as a first step in preclinical
      toxicity testing of new drugs has been largely replaced by experiments that use
      fewer animals, the need to evaluate the radioprotective efficacy of new drugs
      necessitates the conduct of traditional LD(50) comparative studies (FDA, 2002,
      Federal Register 67, 37988-37998). There is, however, no readily available method
      to determine the number of animals needed for establishing efficacy in these
      comparative potency studies. This article presents a sample-size formula based on
      Student's t for comparative potency testing. It is motivated by the U.S. Food and
      Drug Administration's (FDA's) requirements for robust efficacy data in the
      testing of response modifiers in total body irradiation experiments where human
      studies are not ethical or feasible. Monte Carlo simulation demonstrated the
      formula's performance for Student's t, Wald, and likelihood ratio tests in both
      logistic and probit models. Importantly, the results showed clear potential for
      justifying the use of substantially fewer animals than are customarily used in
      these studies. The present article may thus initiate a dialogue among researchers
      who use animals for radioprotection survival studies, institutional animal care
      and use committees, and drug regulatory bodies to reach a consensus on the number
      of animals needed to achieve statistically robust results for demonstrating
      efficacy of radioprotective drugs.
FAU - Kodell, Ralph L
AU  - Kodell RL
AD  - Department of Biostatistics, University of Arkansas for Medical Sciences, Little 
      Rock, Arkansas 72205, USA. rlkodell@uams.edu
FAU - Lensing, Shelly Y
AU  - Lensing SY
FAU - Landes, Reid D
AU  - Landes RD
FAU - Kumar, K Sree
AU  - Kumar KS
FAU - Hauer-Jensen, Martin
AU  - Hauer-Jensen M
LA  - eng
GR  - 27302C0028/ES/NIEHS NIH HHS/United States
GR  - U19 AI067798/AI/NIAID NIH HHS/United States
GR  - U19 AI067798-040003/AI/NIAID NIH HHS/United States
GR  - U19 AI67798/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20090507
PL  - United States
TA  - Biometrics
JT  - Biometrics
JID - 0370625
RN  - 0 (Radiation-Protective Agents)
SB  - IM
MH  - Animals
MH  - Computer Simulation
MH  - Data Interpretation, Statistical
MH  - Drug Evaluation, Preclinical/*methods
MH  - Humans
MH  - Models, Statistical
MH  - Outcome Assessment, Health Care/*methods
MH  - Prevalence
MH  - Radiation Injuries/*drug therapy/*epidemiology
MH  - Radiation Protection/*methods
MH  - Radiation-Protective Agents/*administration & dosage
MH  - *Sample Size
MH  - Treatment Outcome
PMC - PMC3036987
MID - NIHMS117776
EDAT- 2009/05/13 09:00
MHDA- 2010/09/25 06:00
CRDT- 2009/05/13 09:00
PHST- 2009/05/13 09:00 [entrez]
PHST- 2009/05/13 09:00 [pubmed]
PHST- 2010/09/25 06:00 [medline]
AID - BIOM1236 [pii]
AID - 10.1111/j.1541-0420.2009.01236.x [doi]
PST - ppublish
SO  - Biometrics. 2010 Mar;66(1):239-48. doi: 10.1111/j.1541-0420.2009.01236.x. Epub
      2009 May 7.


PMID- 19419781
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110408
LR  - 20190225
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 145
IP  - 3
DP  - 2010 Dec 3
TI  - Retraction of a paper containing plagiarized material: the prognostic value of
      serum troponin T in unstable angina. Gokhan Cin V, Gok H, Kaptanoglu B. Int J
      Cardiol. 1996 Mar;53(3):237-44.
PG  - e81-2
LID - 10.1016/j.ijcard.2008.12.160 [doi]
AB  - On the 6th December 2008, in my role as Editor-in-Chief of the International
      Journal of Cardiology, I received an email from Professor Harold Garner of UT
      Southwestern Medical Center, Dallas. Professor Garner told me that using a new
      search engine methodology (eTBLAST) he and colleagues had identified a paper in
      the International Journal of Cardiology published in 1996 which had remarkable
      text and data similarity to an earlier paper published in 1992 in the New England
      Journal of Medicine. They had detected this similarity after randomly selecting
      citations from Medline and submitting them to the tool to find other highly
      similar citations as part of their NIH/R01 funded research on the ethics of
      publication. We have been notified that all such cases are reported in a
      database, Deja Vu (http://spore.swmed.edu/dejavu/). We investigated the text of
      the two papers and we agreed that there was such a similarity that the later
      paper must have plagiarized the earlier paper, and in doing so infringed the
      copyright. In accordance with our previously published standards on ethical
      publishing in the Journal we hereby retract the paper "The prognostic value of
      serum troponin T in unstable angina. Gokhan Cin V, Gok H, Kaptanoglu B. Int J
      Cardiol. 1996 Mar;53(3):237-44.".
CI  - Copyright (c) 2008 Elsevier Ireland Ltd. All rights reserved.
FAU - Coats, Andrew J S
AU  - Coats AJ
LA  - eng
PT  - Retraction of Publication
DEP - 20090505
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
ROF - Gokhan Cin V, Gok H, Kaptanoglu B. Int J Cardiol. 1996 Mar;53(3):237-44. PMID:
      8793576
EDAT- 2009/05/08 09:00
MHDA- 2011/04/09 06:00
CRDT- 2009/05/08 09:00
PHST- 2008/12/23 00:00 [received]
PHST- 2008/12/23 00:00 [accepted]
PHST- 2009/05/08 09:00 [entrez]
PHST- 2009/05/08 09:00 [pubmed]
PHST- 2011/04/09 06:00 [medline]
AID - S0167-5273(08)01594-5 [pii]
AID - 10.1016/j.ijcard.2008.12.160 [doi]
PST - ppublish
SO  - Int J Cardiol. 2010 Dec 3;145(3):e81-2. doi: 10.1016/j.ijcard.2008.12.160. Epub
      2009 May 5.


PMID- 19413915
OWN - NLM
STAT- MEDLINE
DCOM- 20100614
LR  - 20100309
IS  - 1475-2670 (Electronic)
IS  - 0007-4853 (Linking)
VI  - 100
IP  - 2
DP  - 2010 Apr
TI  - Comparison of synthetic membranes in the development of an in vitro feeding
      system for Dermanyssus gallinae.
PG  - 127-32
LID - 10.1017/S0007485309006865 [doi]
AB  - Although artificial feeding models for the poultry red mite (Dermanyssus
      gallinae) most frequently use biological membranes consisting of day-old chick
      skin, there are ethical considerations associated with the use of skin. The few
      studies reported in the literature that have investigated the use of synthetic
      membranes to feed D. gallinae in vitro have reported limited success. The current
      study describes an investigation into the use of synthetic membranes made from
      either Nescofilm or rayon and silicone, used either alone or in combination with 
      different feather or skin extracts, as well as the use of capillary tubes. In
      all, 12 different treatments were used, and the feeding rate of D. gallinae was
      compared to that of day-old chick skin. Allowing mites to feed on a membrane
      consisting of Nescofilm with a skin extract resulted in the highest proportion of
      mites feeding (32.3%), which was not significantly different to the feeding rate 
      of mites on day-old chick skin (38.8%). This study confirms that synthetic
      membranes can be used to feed D. gallinae artificially. Further optimization of
      the membrane and mite storage conditions is still necessary, but the study
      demonstrates a proof of concept.
FAU - Harrington, D W J
AU  - Harrington DW
AD  - School of Agriculture, Food and Rural Development, Newcastle University,
      Newcastle upon Tyne, UK.
FAU - Guy, J H
AU  - Guy JH
FAU - Robinson, K
AU  - Robinson K
FAU - Sparagano, O A E
AU  - Sparagano OA
LA  - eng
GR  - Biotechnology and Biological Sciences Research Council/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090505
PL  - England
TA  - Bull Entomol Res
JT  - Bulletin of entomological research
JID - 2984715R
RN  - 0 (Membranes, Artificial)
SB  - IM
MH  - Animals
MH  - Feeding Methods/*instrumentation
MH  - *Membranes, Artificial
MH  - Mites/*physiology
EDAT- 2009/05/06 09:00
MHDA- 2010/06/15 06:00
CRDT- 2009/05/06 09:00
PHST- 2009/05/06 09:00 [entrez]
PHST- 2009/05/06 09:00 [pubmed]
PHST- 2010/06/15 06:00 [medline]
AID - S0007485309006865 [pii]
AID - 10.1017/S0007485309006865 [doi]
PST - ppublish
SO  - Bull Entomol Res. 2010 Apr;100(2):127-32. doi: 10.1017/S0007485309006865. Epub
      2009 May 5.


PMID- 19398394
OWN - NLM
STAT- MEDLINE
DCOM- 20100525
LR  - 20181201
IS  - 1878-0539 (Electronic)
IS  - 1748-6815 (Linking)
VI  - 63
IP  - 5
DP  - 2010 May
TI  - Evaluation of appearance transfer and persistence in central face
      transplantation: a computer simulation analysis.
PG  - 733-8
LID - 10.1016/j.bjps.2009.01.078 [doi]
AB  - BACKGROUND: Partial facial allotransplantation is an emerging option in
      reconstruction of central facial defects, providing function and aesthetic
      appearance. Ethical debate partly stems from uncertainty surrounding identity
      aspects of the procedure. There is no objective evidence regarding the effect of 
      donors' transplanted facial structures on appearance change of the recipients and
      its influence on facial recognition of donors and recipients. METHODS: Full-face 
      frontal view color photographs of 100 volunteers were taken at a distance of 150 
      cm with a digital camera (Nikon/DX80). Photographs were taken in front of a blue 
      background, and with a neutral facial expression. Using image-editing software
      (Adobe-Photoshop-CS3), central facial transplantation was performed between
      participants. Twenty observers performed a familiar 'facial recognition task', to
      identify 40 post-transplant composite faces presented individually on the screen 
      at a viewing distance of 60 cm, with an exposure time of 5s. Each composite face 
      comprised of a familiar and an unfamiliar face to the observers. Trials were done
      with and without external facial features (head contour, hair and ears). Two
      variables were defined: 'Appearance Transfer' refers to transfer of donor's
      appearance to the recipient. 'Appearance Persistence' deals with the extent of
      recipient's appearance change post-transplantation. A t-test was run to determine
      if the rates of Appearance Transfer differed from Appearance Persistence.
      RESULTS: Average Appearance Transfer rate (2.6%) was significantly lower than
      Appearance Persistence rate (66%) (P<0.001), indicating that donor's appearance
      transfer to the recipient is negligible, whereas recipients will be identified
      the majority of the time. External facial features were important in facial
      recognition of recipients, evidenced by a significant rise in Appearance
      Persistence from 19% in the absence of external features to 66% when those
      features were present (P<0.01). CONCLUSION: This study may be helpful in the
      informed consent process of prospective recipients. It is beneficial for
      education of donors families and is expected to positively affect their decision 
      to consent for facial tissue donation.
CI  - Copyright (c) 2009 British Association of Plastic, Reconstructive and Aesthetic
      Surgeons. Published by Elsevier Ltd. All rights reserved.
FAU - Pomahac, Bohdan
AU  - Pomahac B
AD  - Division of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical
      School, Boston, MA 02115, USA. bpomahac@partners.org
FAU - Aflaki, Pejman
AU  - Aflaki P
FAU - Nelson, Charles
AU  - Nelson C
FAU - Balas, Benjamin
AU  - Balas B
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090423
PL  - Netherlands
TA  - J Plast Reconstr Aesthet Surg
JT  - Journal of plastic, reconstructive & aesthetic surgery : JPRAS
JID - 101264239
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Computer Simulation
MH  - Electronic Data Processing/*methods
MH  - *Facial Expression
MH  - Facial Transplantation/*methods
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Photography
MH  - Transplantation, Homologous
MH  - Young Adult
EDAT- 2009/04/29 09:00
MHDA- 2010/05/26 06:00
CRDT- 2009/04/29 09:00
PHST- 2008/12/11 00:00 [received]
PHST- 2009/01/16 00:00 [revised]
PHST- 2009/01/31 00:00 [accepted]
PHST- 2009/04/29 09:00 [entrez]
PHST- 2009/04/29 09:00 [pubmed]
PHST- 2010/05/26 06:00 [medline]
AID - S1748-6815(09)00211-3 [pii]
AID - 10.1016/j.bjps.2009.01.078 [doi]
PST - ppublish
SO  - J Plast Reconstr Aesthet Surg. 2010 May;63(5):733-8. doi:
      10.1016/j.bjps.2009.01.078. Epub 2009 Apr 23.


PMID- 19381871
OWN - NLM
STAT- MEDLINE
DCOM- 20100319
LR  - 20211020
IS  - 1572-8633 (Electronic)
IS  - 1386-7423 (Linking)
VI  - 13
IP  - 1
DP  - 2010 Feb
TI  - "It's intense, you know." Nurses' experiences in caring for patients requesting
      euthanasia.
PG  - 41-8
LID - 10.1007/s11019-009-9203-1 [doi]
AB  - The Belgian Act on Euthanasia came into force on 23 September 2002, making
      Belgium the second country--after the Netherlands--to decriminalize euthanasia
      under certain due-care conditions. Since then, Belgian nurses have been
      increasingly involved in euthanasia care. In this paper, we report a qualitative 
      study based on in-depth interviews with 18 nurses from Flanders (the
      Dutch-speaking part of Belgium) who have had experience in caring for patients
      requesting euthanasia since May 2002 (the approval of the Act). We found that the
      care process for patients requesting euthanasia is a complex and dynamic process,
      consisting of several stages, starting from the period preceding the euthanasia
      request and ending with the aftercare stage. When asked after the way in which
      they experience their involvement in the euthanasia care process, all nurses
      described it as a grave and difficult process, not only on an organizational and 
      practical level, but also on an emotional level. "Intense" is the dominant
      feeling experienced by nurses. This is compounded by the presence of other
      feelings such as great concern and responsibility on the one hand, being content 
      in truly helping the patient to die serenely, and doing everything in one's power
      to contribute to this; but also feeling unreal and ambivalent on the other hand, 
      because death is arranged. Nurses feel a discrepancy, because although it is a
      nice death, which happens in dignity and with respect, it is also an unnatural
      death. The clinical ethical implications of these findings are discussed.
FAU - Denier, Yvonne
AU  - Denier Y
AD  - Faculty of Medicine, Centre for Biomedical Ethics and Law, Catholic University of
      Leuven, Kapucijnenvoer 35 Blok D-Bus 7001, 3000 Leuven, Belgium.
      Yvonne.Denier@med.kuleuven.be
FAU - Dierckx de Casterle, Bernadette
AU  - Dierckx de Casterle B
FAU - De Bal, Nele
AU  - De Bal N
FAU - Gastmans, Chris
AU  - Gastmans C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090418
PL  - Netherlands
TA  - Med Health Care Philos
JT  - Medicine, health care, and philosophy
JID - 9815900
SB  - IM
MH  - Adult
MH  - Attitude of Health Personnel
MH  - *Emotions
MH  - *Euthanasia, Active
MH  - Female
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Middle Aged
MH  - Nurses/*psychology
MH  - *Philosophy, Medical
MH  - Qualitative Research
EDAT- 2009/04/22 09:00
MHDA- 2010/03/20 06:00
CRDT- 2009/04/22 09:00
PHST- 2009/02/17 00:00 [received]
PHST- 2009/04/01 00:00 [accepted]
PHST- 2009/04/22 09:00 [entrez]
PHST- 2009/04/22 09:00 [pubmed]
PHST- 2010/03/20 06:00 [medline]
AID - 10.1007/s11019-009-9203-1 [doi]
PST - ppublish
SO  - Med Health Care Philos. 2010 Feb;13(1):41-8. doi: 10.1007/s11019-009-9203-1. Epub
      2009 Apr 18.


PMID- 19381693
OWN - NLM
STAT- MEDLINE
DCOM- 20130115
LR  - 20220330
IS  - 1433-7339 (Electronic)
IS  - 0941-4355 (Linking)
VI  - 18
IP  - 1
DP  - 2010 Jan
TI  - Evaluation and comparison of two prognostic scores and the physicians' estimate
      of survival in terminally ill patients.
PG  - 43-9
LID - 10.1007/s00520-009-0628-0 [doi]
AB  - BACKGROUND: Most terminally ill patients request information about their
      remaining life span. Professionals are not generally willing to provide prognosis
      on survival, even though they are expected to be able to do so from their
      clinical experience. This study aims to find out whether the standardized
      instruments Palliative Prognostic Index (PPI) and the Palliative Prognostic Score
      (PaP-S) are appropriate, specific, and sensitive to estimate survival time in
      patients receiving inpatient palliative care in Germany. METHOD: PPI and PaP-S
      were assessed in addition to the core documentation data set of the Hospice and
      Palliative Care Evaluation for patients admitted to the palliative care units in 
      Aachen, Bonn, and Cologne. Time of survival was assessed with repeated phone
      calls to the family and was defined as the difference between the day of
      completion of the instruments (excluded) and the day of death (included).
      RESULTS: Survival time was compared with physicians' estimations and prognostic
      scores in 83 patients. Whereas the estimates of the PPI and the PaP-S correlate
      highly, even higher correlations are found for the physicians' prognosis and the 
      scores. Correlations between survival time and the prognostic scores or
      physicians' prognosis were lower. Physicians' estimations overestimated survival 
      time on average fourfold. Estimations were more often correct for very good and
      very bad prognosis. DISCUSSION: The prognostic scores are not able to produce a
      precise reliable prognosis for the individual patient. Nevertheless, they can be 
      used for ethical decision making and team discussions. Estimating survival time
      from clinical experience seems to be easier for very bad or very good prognosis
      for physicians.
FAU - Stiel, S
AU  - Stiel S
AD  - Department of Palliative Medicine, RWTH Aachen University, Pauwelsstrasse 30,
      52074 Aachen, Germany. sstiel@ukaachen.de
FAU - Bertram, L
AU  - Bertram L
FAU - Neuhaus, S
AU  - Neuhaus S
FAU - Nauck, F
AU  - Nauck F
FAU - Ostgathe, C
AU  - Ostgathe C
FAU - Elsner, F
AU  - Elsner F
FAU - Radbruch, L
AU  - Radbruch L
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Validation Study
DEP - 20090421
PL  - Germany
TA  - Support Care Cancer
JT  - Supportive care in cancer : official journal of the Multinational Association of 
      Supportive Care in Cancer
JID - 9302957
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Germany
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Mortality
MH  - Palliative Care
MH  - Prognosis
MH  - Sensitivity and Specificity
MH  - Statistics, Nonparametric
MH  - Survival Analysis
MH  - Terminally Ill/*statistics & numerical data
PMC - PMC3085748
EDAT- 2009/04/22 09:00
MHDA- 2013/01/16 06:00
CRDT- 2009/04/22 09:00
PHST- 2008/12/16 00:00 [received]
PHST- 2009/03/23 00:00 [accepted]
PHST- 2009/04/22 09:00 [entrez]
PHST- 2009/04/22 09:00 [pubmed]
PHST- 2013/01/16 06:00 [medline]
AID - 10.1007/s00520-009-0628-0 [doi]
PST - ppublish
SO  - Support Care Cancer. 2010 Jan;18(1):43-9. doi: 10.1007/s00520-009-0628-0. Epub
      2009 Apr 21.


PMID- 19376838
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211020
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2011
DP  - 2011
TI  - Informed consent in complementary and alternative medicine.
PG  - 170793
LID - 10.1093/ecam/nep032 [doi]
AB  - The objective of this study was to examine complementary and alternative medicine
      (CAM) practitioners' (i) attitudes toward informed consent and (ii) to assess
      whether standards of practice exist with respect to informed consent, and what
      these standards look like. The design and setting of the study constituted
      face-to-face qualitative interviews with 28 non-MD, community-based providers
      representing 11 different CAM therapeutic modalities. It was found that there is 
      great deal of variability with respect to the informed consent process in CAM
      across providers and modalities. No unique profession-based patterns were
      identified. The content analysis yielded five major categories related to (i)
      general attitude towards the informed consent process, (ii) type and amount of
      information exchange during that process, (iii) disclosure of risks, (iv)
      discussions of alternatives, and (v) potential benefits. There is a widespread
      lack of standards with respect to the practice of informed consent across a broad
      range of CAM modalities. Addressing this problem requires concerted and
      systematic educational, ethical and judicial remedial actions. Informed consent, 
      which is often viewed as a pervasive obligation is medicine, must be reshaped to 
      have therapeutic value. Acknowledging current conceptions and misconception
      surrounding the practice of informed consent may help to bring about this change.
      More translational research is needed to guide this process.
FAU - Caspi, Opher
AU  - Caspi O
AD  - Integrative Medicine Unit, Rabin Medical Center and the Tel-Aviv University,
      Petah Tikva 49100, Israel.
FAU - Shalom, Tamar
AU  - Shalom T
FAU - Holexa, Joshua
AU  - Holexa J
LA  - eng
PT  - Journal Article
DEP - 20101019
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC3146982
EDAT- 2009/04/21 09:00
MHDA- 2009/04/21 09:01
CRDT- 2009/04/21 09:00
PHST- 2008/10/14 00:00 [received]
PHST- 2009/03/03 00:00 [accepted]
PHST- 2009/04/21 09:00 [entrez]
PHST- 2009/04/21 09:00 [pubmed]
PHST- 2009/04/21 09:01 [medline]
AID - 10.1093/ecam/nep032 [doi]
AID - nep032 [pii]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2011;2011:170793. doi: 10.1093/ecam/nep032.
      Epub 2010 Oct 19.


PMID- 19376511
OWN - NLM
STAT- MEDLINE
DCOM- 20100723
LR  - 20171116
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 94
IP  - 2
DP  - 2010 Jul
TI  - The measurements of RAGE, VEGF, and AGEs in the plasma and follicular fluid of
      reproductive women: the influence of aging.
PG  - 694-700
LID - 10.1016/j.fertnstert.2009.03.029 [doi]
AB  - OBJECTIVE: To examine the advanced glycation end products (AGEs), the soluble
      isoform of the receptor for AGEs (sRAGE), and vascular endothelial growth factor 
      (VEGF) concentrations in plasma and follicular fluid (FF) from reproductive-age
      women. DESIGN: Clinical preliminary study based on the regulations of the ethical
      committee at National Center for Child Health and Development (NCCHD). SETTING:
      Women's health clinical office at NCCHD and Aska clinic. PATIENT(S):
      Reproductive-age women, young group (<35 yrs) and old group (>or=35 yrs), who
      agreed to let us use plasma or FF samples for the measurements of AGEs, sRAGE,
      and VEGF. MAIN OUTCOME MEASURE(S): Measurements of AGEs, sRAGE, and VEGF in
      plasma and FF by ELISA to examine the difference by aging and reproductive
      dysfunction. RESULT(S): The plasma concentration of sRAGE was significantly
      higher in the young group; VEGF in FF was significantly higher in the old group. 
      sRAGE in FF showed a tendency of positive correlation with the number of oocytes.
      The plasma sRAGE concentration was significantly correlated positively with FF
      sRAGE and inversely with FF VEGF at the time of egg collection. CONCLUSION(S):
      The measurement results suggest a possibility that RAGE-VEGF regulation may be
      related to reproductive dysfunction in aging women, and that plasma sRAGE might
      be a biologic marker of reproductive condition.
CI  - Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier 
      Inc. All rights reserved.
FAU - Fujii, Eriko Y
AU  - Fujii EY
AD  - Division of Obstetrics & Gynecology, Reproductive Sciences, National Center for
      Child Health and Development, Tokyo, Japan. perky.ef@gmail.com
FAU - Nakayama, Masahiro
AU  - Nakayama M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090418
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
RN  - 0 (Glycation End Products, Advanced)
RN  - 0 (Receptor for Advanced Glycation End Products)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
MH  - Adult
MH  - Age Distribution
MH  - Aging/*metabolism
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Follicular Fluid/*metabolism
MH  - Glycation End Products, Advanced/*blood
MH  - Humans
MH  - Menstrual Cycle/blood
MH  - Middle Aged
MH  - Oocyte Retrieval
MH  - Oocytes/cytology
MH  - Receptor for Advanced Glycation End Products
MH  - Receptors, Immunologic/*blood
MH  - Reproduction/physiology
MH  - Vascular Endothelial Growth Factor A/*blood
MH  - Young Adult
EDAT- 2009/04/21 09:00
MHDA- 2010/07/24 06:00
CRDT- 2009/04/21 09:00
PHST- 2008/11/19 00:00 [received]
PHST- 2009/02/27 00:00 [revised]
PHST- 2009/03/09 00:00 [accepted]
PHST- 2009/04/21 09:00 [entrez]
PHST- 2009/04/21 09:00 [pubmed]
PHST- 2010/07/24 06:00 [medline]
AID - S0015-0282(09)00594-9 [pii]
AID - 10.1016/j.fertnstert.2009.03.029 [doi]
PST - ppublish
SO  - Fertil Steril. 2010 Jul;94(2):694-700. doi: 10.1016/j.fertnstert.2009.03.029.
      Epub 2009 Apr 18.


PMID- 19362501
OWN - NLM
STAT- MEDLINE
DCOM- 20100614
LR  - 20100504
IS  - 1532-2971 (Electronic)
IS  - 1090-0233 (Linking)
VI  - 184
IP  - 3
DP  - 2010 Jun
TI  - Haematological parameters are normal in dominant white Franches-Montagnes horses 
      carrying a KIT mutation.
PG  - 315-7
LID - 10.1016/j.tvjl.2009.02.017 [doi]
AB  - The KIT receptor protein-tyrosine kinase plays an important role during embryonic
      development. Activation of KIT is crucial for the development of various cell
      lineages such as melanoblasts, stem cells of the haematopoietic system,
      spermatogonia and intestinal cells of Cajal. In mice, many mutations in the Kit
      gene cause pigmentation disorders accompanied by pleiotropic effects on blood
      cells and male fertility. Previous work has demonstrated that dominant white
      Franches-Montagnes horses carry one copy of the KIT gene with the p.Y717X
      mutation. The targeted breeding of white horses would be ethically questionable
      if white horses were known to suffer from anaemia or leukopenia. The present
      study demonstrates that no statistically significant differences in peripheral
      blood parameters are detectable between dominant white and solid-coloured
      Franches-Montagnes horses. The data indicate that KIT mutations may have
      different effects in mice, pigs, and horses. The KIT p.Y717X mutation does not
      have a major negative effect on the haematopoietic system of dominant white
      horses.
CI  - Copyright 2009 Elsevier Ltd. All rights reserved.
FAU - Haase, Bianca
AU  - Haase B
AD  - Institute of Genetics, Vetsuisse-Faculty, University of Berne, Bremgartenstr.
      109a, P.O. Box 8466, 3001 Berne, Switzerland.
FAU - Obexer-Ruff, Gabriela
AU  - Obexer-Ruff G
FAU - Dolf, Gaudenz
AU  - Dolf G
FAU - Rieder, Stefan
AU  - Rieder S
FAU - Burger, Dominik
AU  - Burger D
FAU - Poncet, Pierre-Andre
AU  - Poncet PA
FAU - Gerber, Vincent
AU  - Gerber V
FAU - Howard, Judith
AU  - Howard J
FAU - Leeb, Tosso
AU  - Leeb T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090410
PL  - England
TA  - Vet J
JT  - Veterinary journal (London, England : 1997)
JID - 9706281
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-kit)
SB  - IM
MH  - Alleles
MH  - Anemia/blood/genetics/veterinary
MH  - Animal Welfare
MH  - Animals
MH  - Breeding
MH  - DNA Mutational Analysis
MH  - Female
MH  - Genes, Dominant
MH  - Hair
MH  - Hematologic Tests/veterinary
MH  - Horse Diseases/blood/genetics
MH  - Horses/*blood/*genetics
MH  - Leukopenia/blood/genetics/veterinary
MH  - Male
MH  - Pigmentation/*genetics
MH  - Proto-Oncogene Proteins c-kit/*genetics
EDAT- 2009/04/14 09:00
MHDA- 2010/06/15 06:00
CRDT- 2009/04/14 09:00
PHST- 2008/07/28 00:00 [received]
PHST- 2009/02/05 00:00 [revised]
PHST- 2009/02/06 00:00 [accepted]
PHST- 2009/04/14 09:00 [entrez]
PHST- 2009/04/14 09:00 [pubmed]
PHST- 2010/06/15 06:00 [medline]
AID - S1090-0233(09)00101-4 [pii]
AID - 10.1016/j.tvjl.2009.02.017 [doi]
PST - ppublish
SO  - Vet J. 2010 Jun;184(3):315-7. doi: 10.1016/j.tvjl.2009.02.017. Epub 2009 Apr 10.


PMID- 19345658
OWN - NLM
STAT- MEDLINE
DCOM- 20100525
LR  - 20121115
IS  - 1878-0539 (Electronic)
IS  - 1748-6815 (Linking)
VI  - 63
IP  - 5
DP  - 2010 May
TI  - Circumferential body contouring in bariatric and non-bariatric patient.
PG  - 814-9
LID - 10.1016/j.bjps.2009.01.075 [doi]
AB  - BACKGROUND: Obesity is a serious global health-care concern, with rates in Europe
      and North America estimated at about 20-30% of the adult population. Bariatric
      surgery forms the basis of modified surgical approaches to body-contouring
      procedures, especially those involving circumferential abdominoplasty. This
      procedure produces tremendous aesthetic results with very high patient
      satisfaction. We applied this technique, as an alternative to classic
      abdominoplasty, on moderately to severely obese patients and on patients with no 
      excess-weight problem but some degree of skin laxity and with no history of
      bariatric surgery. METHODS: The first author performed 80 consecutive
      circumferential abdominoplasties during a 4-year period. The patients consisted
      of two groups: post-bariatric patients (n=23) and those with no history of
      bariatric surgery (n=57). Factors such as age, gender, duration of the procedure 
      and hospitalisation, among other relevant ones, are studied and the data are
      compared between the two groups, with a third group of patients who underwent,
      during the same period, a classical abdominoplasty (n=38), and with data from the
      literature. RESULTS: Circumferential abdominoplasty produces excellent
      aesthetical results with a high degree of satisfaction for patients with no
      bariatric history. The patients in this group are younger, their preoperative
      weight loss is lower, operative time shorter and per-operative blood loss lower. 
      There is no statistical difference between the groups in terms either of the body
      mass index (BMI) at the time of circumferential abdominoplasty or of the resected
      tissue weight. Morbidity and rate of complications between these groups are not
      significant statistically, as with the case of data available in the literature. 
      Compared with patients undergoing a classical abdominoplasty, we observe more
      complications related to delay in wound healing, less haematoma and less combined
      procedures in cases of circumferential abdominoplasty. CONCLUSIONS:
      Circumferential abdominoplasty is a body-contouring procedure initially developed
      for post-bariatric patients. This procedure can be ethically proposed to patients
      with body-contour deformities in a non-bariatric context (and even to non-obese
      patients with a skin laxity problem), giving excellent results with minor
      morbidity.
CI  - Copyright (c) 2009 British Association of Plastic, Reconstructive and Aesthetic
      Surgeons. Published by Elsevier Ltd. All rights reserved.
FAU - Vico, Pierre G
AU  - Vico PG
AD  - Clinique Saint Jean, Plastic Surgery, 32 bvd du Jardin Botanique, 1000 Brussels, 
      Belgium. pvico@clstjean.be
FAU - De Vooght, Axel
AU  - De Vooght A
FAU - Nokerman, Beatrice
AU  - Nokerman B
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20090331
PL  - Netherlands
TA  - J Plast Reconstr Aesthet Surg
JT  - Journal of plastic, reconstructive & aesthetic surgery : JPRAS
JID - 101264239
SB  - IM
MH  - Abdominal Wall/*surgery
MH  - Adipose Tissue/*surgery
MH  - Adult
MH  - Aged
MH  - Bariatric Surgery/*rehabilitation
MH  - *Dermatologic Surgical Procedures
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity/*surgery
MH  - Postoperative Complications/surgery
MH  - Reconstructive Surgical Procedures/*methods
MH  - Waist Circumference
MH  - Weight Loss
MH  - Young Adult
EDAT- 2009/04/07 09:00
MHDA- 2010/05/26 06:00
CRDT- 2009/04/07 09:00
PHST- 2008/09/17 00:00 [received]
PHST- 2009/01/30 00:00 [revised]
PHST- 2009/01/31 00:00 [accepted]
PHST- 2009/04/07 09:00 [entrez]
PHST- 2009/04/07 09:00 [pubmed]
PHST- 2010/05/26 06:00 [medline]
AID - S1748-6815(09)00205-8 [pii]
AID - 10.1016/j.bjps.2009.01.075 [doi]
PST - ppublish
SO  - J Plast Reconstr Aesthet Surg. 2010 May;63(5):814-9. doi:
      10.1016/j.bjps.2009.01.075. Epub 2009 Mar 31.


PMID- 19343499
OWN - NLM
STAT- MEDLINE
DCOM- 20111122
LR  - 20211020
IS  - 1573-3394 (Electronic)
IS  - 1065-3058 (Linking)
VI  - 18
IP  - 2
DP  - 2010 Jun
TI  - Public financing of IVF: a review of policy rationales.
PG  - 113-28
LID - 10.1007/s10728-009-0114-3 [doi]
AB  - There is great diversity in in vitro fertilization (IVF) funding and
      reimbursement policies and practice throughout Europe and the rest of the world. 
      While many existing reimbursement and regulatory frameworks address safety and
      legal concerns, economic factors also assume a central role. However, there are
      several problems with the evidence that is available on the economics of IVF.
      This suggests there is a need for more robust cost-effectiveness studies. It also
      indicates the need for alternative rationales to justify the reimbursement of
      IVF, which might more fully account for the social, political, ethical, and
      philosophical considerations embedded in notions of infertility and
      technology-driven reproductive treatments. The merits and limitations of five
      alternative rationales are discussed. The review suggests that while no existing 
      single rationale provides a complete framework with which to support funding
      decisions, taken together they provide guideposts which signal important issues
      for consideration and highlight where further research, action, and debate are
      needed.
FAU - Mladovsky, Philipa
AU  - Mladovsky P
AD  - London School of Economics, LSE Health, Cowdray House, Houghton Street, London,
      WC2A 2AE, UK. p.mladovsky@lse.ac.uk
FAU - Sorenson, Corinna
AU  - Sorenson C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20090403
PL  - Netherlands
TA  - Health Care Anal
JT  - Health care analysis : HCA : journal of health philosophy and policy
JID - 9432537
MH  - Adult
MH  - Developed Countries
MH  - Female
MH  - Fertilization in Vitro/*economics
MH  - *Financing, Government
MH  - Humans
MH  - Infertility, Female/*economics/therapy
MH  - Public Policy/*economics
EDAT- 2009/04/04 09:00
MHDA- 2011/12/13 00:00
CRDT- 2009/04/04 09:00
PHST- 2008/06/03 00:00 [received]
PHST- 2009/02/04 00:00 [accepted]
PHST- 2009/04/04 09:00 [entrez]
PHST- 2009/04/04 09:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/s10728-009-0114-3 [doi]
PST - ppublish
SO  - Health Care Anal. 2010 Jun;18(2):113-28. doi: 10.1007/s10728-009-0114-3. Epub
      2009 Apr 3.


PMID- 19342036
OWN - NLM
STAT- MEDLINE
DCOM- 20100525
LR  - 20151119
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 93
IP  - 7
DP  - 2010 May 1
TI  - The ethics of sex selection: a comparison of the attitudes and experiences of
      primary care physicians and physician providers of clinical sex selection
      services.
PG  - 2107-14
LID - 10.1016/j.fertnstert.2009.02.053 [doi]
AB  - OBJECTIVE: To compare the perspectives of primary care physicians (PCPs) and
      physician sex-selection technology providers (SSTPs) about the ethics of sex
      selection. DESIGN: Qualitative interview study. SETTING(S): Academic, private,
      and HMO-based infertility and general medical practices. PATIENT(S): Forty PCPs
      and 15 SSTPs. INTERVENTION(S): Semistructured interviews. MAIN OUTCOME
      MEASURE(S): Comparisons of bioethical attitudes towards sex selection. RESULT(S):
      Primary care physicians and SSTPs had distinctly different perceptions of the
      ethical concepts of autonomy, beneficence, and nonmaleficence as applied to sex
      selection. Sex-selection technology providers argued that sex selection was an
      expression of reproductive rights, was initiated and pursued by women, and was a 
      sign of female empowerment that allowed couples to make well-informed family
      planning decisions, prevented unwanted pregnancies and abortions, and minimized
      the abuse of wives and/or neglect of children. In contrast, PCPs challenged the
      concept of "family balancing" and questioned whether women could truly express
      free choice under family and community pressure. In addition, PCPs voiced the
      concerns that sex selection technologies led to invasive medical interventions in
      the absence of therapeutic indications, contributed to gender stereotypes that
      could result in neglect of children of the lesser-desired sex, and were not a
      solution to domestic violence. CONCLUSION(S): Primary care physicians and SSTPs
      had markedly different ethical perspectives on the provision of sex selection
      services that were informed by their professional and personal attitudes and
      experiences.
CI  - Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier 
      Inc. All rights reserved.
FAU - Puri, Sunita
AU  - Puri S
AD  - School of Medicine, University of California, San Francisco, California, USA.
      Sunita.Puri@ucsf.edu
FAU - Nachtigall, Robert D
AU  - Nachtigall RD
LA  - eng
PT  - Journal Article
DEP - 20090401
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Attitude of Health Personnel
MH  - Choice Behavior/ethics
MH  - Female
MH  - Health Personnel/ethics/psychology
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Middle Aged
MH  - Personal Autonomy
MH  - Physician's Role/psychology
MH  - Physician-Patient Relations/ethics
MH  - Physicians, Family/*psychology
MH  - Pregnancy
MH  - Reproductive Rights/ethics/psychology
MH  - Reproductive Techniques, Assisted/*ethics/legislation & jurisprudence/*psychology
MH  - Sex Preselection/*ethics/*psychology
MH  - Surveys and Questionnaires
EDAT- 2009/04/04 09:00
MHDA- 2010/05/26 06:00
CRDT- 2009/04/04 09:00
PHST- 2008/11/17 00:00 [received]
PHST- 2009/02/03 00:00 [revised]
PHST- 2009/02/14 00:00 [accepted]
PHST- 2009/04/04 09:00 [entrez]
PHST- 2009/04/04 09:00 [pubmed]
PHST- 2010/05/26 06:00 [medline]
AID - S0015-0282(09)00472-5 [pii]
AID - 10.1016/j.fertnstert.2009.02.053 [doi]
PST - ppublish
SO  - Fertil Steril. 2010 May 1;93(7):2107-14. doi: 10.1016/j.fertnstert.2009.02.053.
      Epub 2009 Apr 1.


PMID- 19340434
OWN - NLM
STAT- MEDLINE
DCOM- 20100422
LR  - 20100201
IS  - 1434-3916 (Electronic)
IS  - 0936-8051 (Linking)
VI  - 130
IP  - 3
DP  - 2010 Mar
TI  - A new conservative-dynamic treatment for the acute ruptured Achilles tendon.
PG  - 363-8
LID - 10.1007/s00402-009-0865-1 [doi]
AB  - INTRODUCTION: There is a trend towards surgical treatment of acute ruptured
      Achilles tendon. While classical open surgical procedures have been shown to
      restore good functional capacity, they are potentially associated with
      significant complications like wound infection and paresthesia. Modern
      mini-invasive surgical techniques significantly reduce these complications and
      are also associated with good functional results so that they can be considered
      as the surgical treatment of choice. Nevertheless, there is still a need for
      conservative alternative and recent studies report good results with conservative
      treatment in rigid casts or braces. PATIENTS/METHOD: We report the use of a
      dynamic ankle brace in the conservative treatment of Achilles tendon rupture in a
      prospective non-randomised study of 57 consecutive patients. Patients were
      evaluated at an average follow-up time of 5 years using the modified Leppilahti
      Ankle Score, and the first 30 patients additionally underwent a clinical
      examination and muscular testing with a Cybex isokinetic dynamometer at 6 and 12 
      months. RESULTS: We found good and excellent results in most cases. We observed
      five complete re-ruptures, almost exclusively in case of poor patient's
      compliance, two partial re-ruptures and one deep venous thrombosis complicated by
      pulmonary embolism. CONCLUSION: Although prospective comparison with other modern
      treatment options is still required, the functional outcome after early ankle
      mobilisation in a dynamic cast is good enough to ethically propose this method as
      an alternative to surgical treatment.
FAU - Neumayer, Felix
AU  - Neumayer F
AD  - Department of Orthopaedics and Trauma Surgery, University Hospital (CHUV),
      Lausanne, Switzerland.
FAU - Mouhsine, Elyazid
AU  - Mouhsine E
FAU - Arlettaz, Yvan
AU  - Arlettaz Y
FAU - Gremion, Gerald
AU  - Gremion G
FAU - Wettstein, Michael
AU  - Wettstein M
FAU - Crevoisier, Xavier
AU  - Crevoisier X
LA  - eng
PT  - Journal Article
DEP - 20090402
PL  - Germany
TA  - Arch Orthop Trauma Surg
JT  - Archives of orthopaedic and trauma surgery
JID - 9011043
SB  - IM
MH  - Achilles Tendon/*injuries
MH  - Adult
MH  - Aged
MH  - *Braces
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Muscle Strength Dynamometer
MH  - Patient Compliance
MH  - Prospective Studies
MH  - Recurrence
MH  - Rupture/physiopathology/therapy
MH  - Treatment Outcome
EDAT- 2009/04/03 09:00
MHDA- 2010/04/23 06:00
CRDT- 2009/04/03 09:00
PHST- 2009/01/06 00:00 [received]
PHST- 2009/04/03 09:00 [entrez]
PHST- 2009/04/03 09:00 [pubmed]
PHST- 2010/04/23 06:00 [medline]
AID - 10.1007/s00402-009-0865-1 [doi]
PST - ppublish
SO  - Arch Orthop Trauma Surg. 2010 Mar;130(3):363-8. doi: 10.1007/s00402-009-0865-1.
      Epub 2009 Apr 2.


PMID- 19321505
OWN - NLM
STAT- MEDLINE
DCOM- 20100127
LR  - 20091230
IS  - 1468-2044 (Electronic)
IS  - 0003-9888 (Linking)
VI  - 95
IP  - 1
DP  - 2010 Jan
TI  - Drug development for children: how adequate is the current European ethical
      guidance?
PG  - 3-6
LID - 10.1136/adc.2007.135103 [doi]
FAU - Westra, A E
AU  - Westra AE
AD  - Leiden University Medical Center, Department of Paediatrics, PO Box 9600, 2300 RC
      Leiden, The Netherlands. a.e.westra@lumc.nl
FAU - Engberts, D P
AU  - Engberts DP
FAU - Sukhai, R N
AU  - Sukhai RN
FAU - Wit, J M
AU  - Wit JM
FAU - de Beaufort, I D
AU  - de Beaufort ID
LA  - eng
PT  - Journal Article
DEP - 20090325
PL  - England
TA  - Arch Dis Child
JT  - Archives of disease in childhood
JID - 0372434
SB  - IM
MH  - Child
MH  - Drug Approval
MH  - Drug Discovery/*ethics
MH  - *Ethics, Research
MH  - European Union
MH  - Humans
MH  - Pediatrics/*ethics
MH  - Practice Guidelines as Topic
EDAT- 2009/03/27 09:00
MHDA- 2010/01/28 06:00
CRDT- 2009/03/27 09:00
PHST- 2009/03/27 09:00 [entrez]
PHST- 2009/03/27 09:00 [pubmed]
PHST- 2010/01/28 06:00 [medline]
AID - adc.2007.135103 [pii]
AID - 10.1136/adc.2007.135103 [doi]
PST - ppublish
SO  - Arch Dis Child. 2010 Jan;95(1):3-6. doi: 10.1136/adc.2007.135103. Epub 2009 Mar
      25.


PMID- 19308731
OWN - NLM
STAT- MEDLINE
DCOM- 20101203
LR  - 20211020
IS  - 1557-1920 (Electronic)
IS  - 1557-1912 (Linking)
VI  - 12
IP  - 5
DP  - 2010 Oct
TI  - Ethics and the compensation of immigrant workers for work-related injuries and
      illnesses.
PG  - 707-14
LID - 10.1007/s10903-008-9208-5 [doi]
AB  - This paper examines the compensation process for work-related injuries and
      illnesses by assessing the trajectories of a sample of immigrant and
      non-immigrant workers (n = 104) in Montreal. Workers were interviewed to analyze 
      the complexity associated with the compensation process. Experts specialized in
      compensation issues assessed the difficulty of the interviewees' compensation
      process. Immigrant workers faced greater difficulties with medical, legal, and
      administrative issues than non-immigrants did. While immigrant workers' claim
      forms tended to be written more often by employers or friends (58% vs. 8%), the
      claims were still more often contested by employers (64% vs. 24%). Immigrant
      workers were less likely to obtain a precise diagnosis (64% vs. 42%) and upon
      returning to work were more likely to face sub-optimal conditions. Such results
      throw into relief issues of ethics and equity in host societies that are building
      their economy with migrant workers.
FAU - Gravel, Sylvie
AU  - Gravel S
AD  - Department of Management, Business School, Quebec University at Montreal,
      Interuniversity Research Center on integration and immigration Metropolis,
      succursale Downtown, Montreal, QC, Canada. gravel.s@uqam.qc.ca
FAU - Vissandjee, Bilkis
AU  - Vissandjee B
FAU - Lippel, Katherine
AU  - Lippel K
FAU - Brodeur, Jean-Marc
AU  - Brodeur JM
FAU - Patry, Louis
AU  - Patry L
FAU - Champagne, Francois
AU  - Champagne F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090324
PL  - United States
TA  - J Immigr Minor Health
JT  - Journal of immigrant and minority health
JID - 101256527
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Emigrants and Immigrants
MH  - Female
MH  - Health Services Accessibility
MH  - Healthcare Disparities
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Quebec
MH  - Workers' Compensation/economics/*ethics
MH  - *Wounds and Injuries/diagnosis/economics/ethnology
MH  - Young Adult
EDAT- 2009/03/25 09:00
MHDA- 2010/12/14 06:00
CRDT- 2009/03/25 09:00
PHST- 2008/05/15 00:00 [received]
PHST- 2008/11/03 00:00 [accepted]
PHST- 2009/03/25 09:00 [entrez]
PHST- 2009/03/25 09:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1007/s10903-008-9208-5 [doi]
PST - ppublish
SO  - J Immigr Minor Health. 2010 Oct;12(5):707-14. doi: 10.1007/s10903-008-9208-5.
      Epub 2009 Mar 24.


PMID- 19301418
OWN - NLM
STAT- MEDLINE
DCOM- 20100429
LR  - 20100210
IS  - 1099-1050 (Electronic)
IS  - 1057-9230 (Linking)
VI  - 19
IP  - 2
DP  - 2010 Feb
TI  - Ordinal and cardinal measures of health inequality: an empirical comparison.
PG  - 243-50
LID - 10.1002/hec.1472 [doi]
AB  - When measuring health inequality using ordinal data, analysts typically must
      choose between indices specifically based upon ordinal data and more standard
      indices using ordinal data, which has been transformed into cardinal data. This
      paper compares inequality rankings across a number of different approaches and
      finds considerable sensitivity to the choice between ordinal- and cardinal-based 
      indices. There is relatively little sensitivity to the ethical choices made by
      the analyst in terms of the weight attached to different parts of the
      distribution.
CI  - Copyright (c) 2009 John Wiley & Sons, Ltd.
FAU - Madden, David
AU  - Madden D
AD  - School of Economics, University College, Dublin, Ireland. david.madden@ucd.ie
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Health Econ
JT  - Health economics
JID - 9306780
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Female
MH  - *Health Status Disparities
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Models, Statistical
MH  - Sensitivity and Specificity
MH  - Social Class
MH  - Young Adult
EDAT- 2009/03/21 09:00
MHDA- 2010/04/30 06:00
CRDT- 2009/03/21 09:00
PHST- 2009/03/21 09:00 [entrez]
PHST- 2009/03/21 09:00 [pubmed]
PHST- 2010/04/30 06:00 [medline]
AID - 10.1002/hec.1472 [doi]
PST - ppublish
SO  - Health Econ. 2010 Feb;19(2):243-50. doi: 10.1002/hec.1472.


PMID- 19288201
OWN - NLM
STAT- MEDLINE
DCOM- 20111122
LR  - 20211020
IS  - 1573-3394 (Electronic)
IS  - 1065-3058 (Linking)
VI  - 18
IP  - 2
DP  - 2010 Jun
TI  - Public perceptions of ethical issues regarding adult predictive genetic testing.
PG  - 103-12
LID - 10.1007/s10728-009-0113-4 [doi]
AB  - The purpose of this study was to explore the views of members of the general
      public regarding ethical issues in adult predictive genetic testing. The
      literature pertaining to ethical issues regarding to adult predictive genetic
      testing is largely restricted to the views of 'experts' who have emphasized
      informed consent, patent issues, and insurance discrimination. Occasionally the
      views of patients who have undergone genetic counselling and testing have been
      elicited, adding psychosocial and family issues. However, the general public has 
      not had the opportunity to contribute. In order to explore theatre as a health
      policy research tool, 1,200 audience members attended the play 'Sarah's
      Daughters' in seven Canadian cities, following which audience discussions were
      audiotaped. This study performed a secondary qualitative analysis of the data to 
      identify the ethical issues of adult predictive genetic testing important to
      members of the general public. The identified issues were: (1) need for public
      education; (2) choice to undergo genetic counselling and testing; (3) access to
      genetic counselling and testing; and (4) obligations regarding the handling of
      genetic information. Audience members emphasized public education and access to
      information regarding potential choices, which was different from the emphasis on
      informed consent and other ethical issues prominent in the literature. Members of
      the general public emphasized ethical issues that were different than those
      identified by experts and patients. It is essential that members of the public be
      included in complex and controversial public policy decisions.
FAU - Martin, Douglas K
AU  - Martin DK
AD  - Department of Health Policy, Management and Evaluation and the Joint Centre for
      Bioethics, University of Toronto, 88 College St., Toronto, ON, M5G 1L4, Canada.
      douglas.martin@utoronto.ca
FAU - Greenwood, Heather L
AU  - Greenwood HL
FAU - Nisker, Jeff
AU  - Nisker J
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090314
PL  - Netherlands
TA  - Health Care Anal
JT  - Health care analysis : HCA : journal of health philosophy and policy
JID - 9432537
MH  - Adult
MH  - Attitude to Health
MH  - Canada
MH  - Disclosure
MH  - Drama
MH  - Genetic Counseling
MH  - *Genetic Predisposition to Disease
MH  - Genetic Testing/*ethics
MH  - Health Education
MH  - Humans
MH  - *Public Opinion
MH  - Qualitative Research
EDAT- 2009/03/17 09:00
MHDA- 2011/12/13 00:00
CRDT- 2009/03/17 09:00
PHST- 2008/03/05 00:00 [received]
PHST- 2009/02/04 00:00 [accepted]
PHST- 2009/03/17 09:00 [entrez]
PHST- 2009/03/17 09:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/s10728-009-0113-4 [doi]
PST - ppublish
SO  - Health Care Anal. 2010 Jun;18(2):103-12. doi: 10.1007/s10728-009-0113-4. Epub
      2009 Mar 14.


PMID- 19285663
OWN - NLM
STAT- MEDLINE
DCOM- 20100525
LR  - 20100426
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 93
IP  - 7
DP  - 2010 May 1
TI  - The views of adult offspring of sperm donation: essential feedback for the
      development of ethical guidelines within the practice of assisted reproductive
      technology in the United States.
PG  - 2236-46
LID - 10.1016/j.fertnstert.2008.12.119 [doi]
AB  - OBJECTIVE: To provide an in-depth analysis of offspring attitudes toward their
      means of conception and the practice of sperm donation in the United States.
      DESIGN: Survey-based study using a 46-item questionnaire. PATIENT(S): Eighty-five
      adult offspring of sperm donation. INTERVENTION(S): Participants were recruited
      through an Internet-based support group for adults conceived through sperm
      donation. Eighty-five of them completed the questionnaire provided through a link
      to another Internet site. MAIN OUTCOME MEASURE(S): Responses to a 46-item
      questionnaire. RESULT(S): A majority of offspring learned of their conception at 
      age >18 years during a planned conversation; had no information about their
      donor; viewed their donor as their "biological father"; had searched for and
      wanted identifying information on their donor and half-siblings; and supported
      the provision of extensive nonidentifying information or identity release in the 
      practice of sperm donation. Participant attitudes toward their means of
      conception were evenly distributed from "very good" to "very bad." Other
      descriptive information on participants contributed to an understanding of their 
      attitudes. CONCLUSION(S): Participant ratings of their conception were evenly
      distributed from "very good" to "very bad." Most believed that identifying
      information should be provided to recipients and that they themselves would not
      participate in the practice of gamete donation.
CI  - Copyright 2010. Published by Elsevier Inc.
FAU - Mahlstedt, Patricia P
AU  - Mahlstedt PP
FAU - LaBounty, Kathleen
AU  - LaBounty K
FAU - Kennedy, William Thomas
AU  - Kennedy WT
LA  - eng
PT  - Journal Article
DEP - 20090314
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Adult Children/*psychology
MH  - Attitude
MH  - Codes of Ethics
MH  - Consensus
MH  - Data Collection
MH  - Feedback
MH  - Female
MH  - Humans
MH  - Infertility, Male/*therapy
MH  - Insemination, Artificial, Heterologous/*ethics/psychology
MH  - Legal Guardians/psychology
MH  - Male
MH  - Middle Aged
MH  - *Practice Guidelines as Topic
MH  - Reproductive Techniques, Assisted/*ethics/psychology
MH  - Spermatozoa/transplantation
MH  - Tissue and Organ Procurement/*ethics
MH  - United States
MH  - Young Adult
EDAT- 2009/03/17 09:00
MHDA- 2010/05/26 06:00
CRDT- 2009/03/17 09:00
PHST- 2008/06/24 00:00 [received]
PHST- 2008/12/01 00:00 [revised]
PHST- 2008/12/22 00:00 [accepted]
PHST- 2009/03/17 09:00 [entrez]
PHST- 2009/03/17 09:00 [pubmed]
PHST- 2010/05/26 06:00 [medline]
AID - S0015-0282(08)04835-8 [pii]
AID - 10.1016/j.fertnstert.2008.12.119 [doi]
PST - ppublish
SO  - Fertil Steril. 2010 May 1;93(7):2236-46. doi: 10.1016/j.fertnstert.2008.12.119.
      Epub 2009 Mar 14.


PMID- 19264550
OWN - NLM
STAT- MEDLINE
DCOM- 20100301
LR  - 20190429
IS  - 1873-5223 (Electronic)
IS  - 1471-5953 (Linking)
VI  - 10
IP  - 1
DP  - 2010 Jan
TI  - The transition to blended e-learning. Changing the focus of educational delivery 
      in children's pain management.
PG  - 1-7
LID - 10.1016/j.nepr.2009.01.015 [doi]
AB  - Many health professionals within the UK experience difficulty in accessing
      further education due to increased workload, reduction in budgets and personal
      commitments. This paper discusses the redevelopment of a children's pain
      management (CPM) module to blended e-learning in response to changing workforce
      needs. The rationale for changing the pedagogy which underpinned the mode of
      delivery of the module was associated with a number of factors. Reduction in
      student numbers, difficulties with nurses being released from their practice
      setting and a desire from stakeholders to maintain pain management education. An 
      on-line questionnaire was utilised to undertake a module evaluation which formed 
      part of the University teaching and learning strategy. Evaluations were generally
      positive, however, some ethical and professional issues emerged surrounding a
      lack of study time and level of computer expertise amongst the students.
      Negotiation is being undertaken with stakeholders to ensure future students are
      provided with protected study time. Further development with electronic
      assignment submission will enable the module to be accessible to a wider national
      and international audience. Change of module delivery to blended e-learning has
      assisted the health professional to learn in a manner that is adaptable to their 
      workplace and promotes life-long learning by development of independent learning 
      skills.
FAU - Jonas, Denise
AU  - Jonas D
AD  - University of Salford, School of Nursing, Allerton Campus, Frederick Road,
      Manchester, Salford M6 6PU, United Kingdom. d.a.jonas@salford.ac.uk
FAU - Burns, Bernadette
AU  - Burns B
LA  - eng
PT  - Journal Article
DEP - 20090304
PL  - Scotland
TA  - Nurse Educ Pract
JT  - Nurse education in practice
JID - 101090848
SB  - IM
MH  - Education, Nursing, Continuing/*methods
MH  - Humans
MH  - *Internet
MH  - *Learning
MH  - Pain/*nursing
MH  - Pain Management
MH  - Pediatric Nursing
MH  - State Medicine
MH  - Surveys and Questionnaires
MH  - United Kingdom
EDAT- 2009/03/07 09:00
MHDA- 2010/03/02 06:00
CRDT- 2009/03/07 09:00
PHST- 2007/12/14 00:00 [received]
PHST- 2009/01/21 00:00 [revised]
PHST- 2009/01/25 00:00 [accepted]
PHST- 2009/03/07 09:00 [entrez]
PHST- 2009/03/07 09:00 [pubmed]
PHST- 2010/03/02 06:00 [medline]
AID - S1471-5953(09)00016-X [pii]
AID - 10.1016/j.nepr.2009.01.015 [doi]
PST - ppublish
SO  - Nurse Educ Pract. 2010 Jan;10(1):1-7. doi: 10.1016/j.nepr.2009.01.015. Epub 2009 
      Mar 4.


PMID- 19259820
OWN - NLM
STAT- MEDLINE
DCOM- 20100915
LR  - 20211020
IS  - 1573-6571 (Electronic)
IS  - 0022-4197 (Linking)
VI  - 49
IP  - 2
DP  - 2010 Jun
TI  - Health care chaplains and their role on institutional ethics committees: an
      Australia study.
PG  - 221-32
LID - 10.1007/s10943-009-9241-2 [doi]
AB  - This paper presents the results of the largest Australian pastoral study
      concerning the perceptions of health care chaplains about their involvement on
      hospital research ethics committees (also known in some contexts as institutional
      ethics committees). Survey results from over 300 Australian health care chaplains
      indicated that nearly 90% of chaplains believed there was merit in chaplains
      serving on hospital research ethics committees, yet only a minority (22.7%) had
      ever participated on such committees. Data from in-depth interviews is also
      presented exploring the reasons for the lack of participation and the varying
      opinions regarding the role, appropriateness, and value of chaplains on ethics
      committees. Some implications of this study with respect to chaplaincy, hospital 
      research ethics committees, health care institutions, ecclesiastical
      institutions, and government responsibilities are discussed.
FAU - Carey, Lindsay B
AU  - Carey LB
AD  - Palliative Care Unit, School of Public Health, La Trobe University, Melbourne,
      3000, Australia. lindsay.carey@latrobe.edu.au
FAU - Cohen, Jeffrey
AU  - Cohen J
LA  - eng
PT  - Journal Article
DEP - 20090304
PL  - United States
TA  - J Relig Health
JT  - Journal of religion and health
JID - 2985199R
SB  - IM
MH  - Australia
MH  - Chaplaincy Service, Hospital/*ethics/*standards
MH  - Christianity
MH  - Ethics Committees/*ethics
MH  - *Ethics, Professional
MH  - Female
MH  - Humans
MH  - Male
MH  - Pastoral Care/ethics/standards
MH  - *Professional Role
EDAT- 2009/03/05 09:00
MHDA- 2010/09/16 06:00
CRDT- 2009/03/05 09:00
PHST- 2008/09/17 00:00 [received]
PHST- 2009/02/09 00:00 [accepted]
PHST- 2009/03/05 09:00 [entrez]
PHST- 2009/03/05 09:00 [pubmed]
PHST- 2010/09/16 06:00 [medline]
AID - 10.1007/s10943-009-9241-2 [doi]
PST - ppublish
SO  - J Relig Health. 2010 Jun;49(2):221-32. doi: 10.1007/s10943-009-9241-2. Epub 2009 
      Mar 4.


PMID- 19247810
OWN - NLM
STAT- MEDLINE
DCOM- 20100701
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 16
IP  - 1
DP  - 2010 Mar
TI  - Ethical research in delirium: arguments for including decisionally incapacitated 
      subjects.
PG  - 169-74
LID - 10.1007/s11948-009-9120-y [doi]
AB  - Here we describe how more important findings were obtained in a delirium study by
      using an informal assessment of mental capacity, and, in those who lacked
      capacity, obtaining consent later when or if capacity returned or a proxy was
      found. From a total of 233 patients 23 patients lacked capacity as judged by our 
      informal capacity judgment and 210 did not. Of those who lacked capacity, 13
      agreed to enter in the study. Six of them regained capacity later. When these 13 
      participants were excluded from analysis, significant findings were no longer
      evident. These results show that by the inclusion of subjects who lacked capacity
      the results of analyses of the condition from whish they suffer are altered. We
      suggest that this approach to the study of delirium is more ethical than the
      usual system of strict exclusion of people who lack capacity to give consent and 
      for whom assent is not available.
FAU - Adamis, Dimitrios
AU  - Adamis D
AD  - Research and Academic Institute of Athens, 27 Themistokleous Street & Akadimias, 
      Athens 106 77, Greece. dimaadamis@yahoo.com
FAU - Treloar, Adrian
AU  - Treloar A
FAU - Martin, Finbarr C
AU  - Martin FC
FAU - Macdonald, Alastair J D
AU  - Macdonald AJ
LA  - eng
PT  - Journal Article
DEP - 20090227
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomedical Research/*ethics
MH  - Codes of Ethics
MH  - Decision Making/ethics
MH  - *Delirium/diagnosis
MH  - Double Effect Principle
MH  - Female
MH  - Geriatric Assessment
MH  - Guidelines as Topic
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Judgment/ethics
MH  - Male
MH  - *Mental Competency
MH  - Mental Status Schedule
MH  - Patient Rights/ethics
MH  - Patient Selection/*ethics
MH  - Principle-Based Ethics
MH  - *Research Subjects
MH  - Severity of Illness Index
MH  - Statistics, Nonparametric
EDAT- 2009/02/28 09:00
MHDA- 2010/07/02 06:00
CRDT- 2009/02/28 09:00
PHST- 2008/09/11 00:00 [received]
PHST- 2009/01/28 00:00 [accepted]
PHST- 2009/02/28 09:00 [entrez]
PHST- 2009/02/28 09:00 [pubmed]
PHST- 2010/07/02 06:00 [medline]
AID - 10.1007/s11948-009-9120-y [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2010 Mar;16(1):169-74. doi: 10.1007/s11948-009-9120-y. Epub 2009 
      Feb 27.


PMID- 19234760
OWN - NLM
STAT- MEDLINE
DCOM- 20100319
LR  - 20211020
IS  - 1572-8633 (Electronic)
IS  - 1386-7423 (Linking)
VI  - 13
IP  - 1
DP  - 2010 Feb
TI  - Some comments on the substituted judgement standard.
PG  - 33-40
LID - 10.1007/s11019-009-9194-y [doi]
AB  - On a traditional interpretation of the substituted judgement standard (SJS) a
      person who makes treatment decisions on behalf of a non-competent patient (e.g.
      concerning euthanasia) ought to decide as the patient would have decided had she 
      been competent. I propose an alternative interpretation of SJS in which the
      surrogate is required to infer what the patient actually thought about these
      end-of-life decisions. In clarifying SJS it is also important to differentiate
      the patient's consent and preference. If SJS is part of an autonomy ideal of the 
      sort found in Kantian ethics, consent seems more important than preference. From 
      a utilitarian perspective a preference-based reading of SJS seems natural. I
      argue that the justification of SJS within a utilitarian framework will boil down
      to the question whether a non-competent patient can be said to have any surviving
      preferences. If we give a virtue-ethical justification of SJS the relative
      importance of consent and preferences depends on which virtue one
      stresses--respect or care. I argue that SJS might be an independent normative
      method for extending the patient's autonomy, both from a Kantian and a virtue
      ethical perspective.
FAU - Egonsson, Dan
AU  - Egonsson D
AD  - Department of Philosophy, Lund University, Kungshuset 22222, Lund, Sweden.
      Dan.Egonsson@fil.lu.se
LA  - eng
PT  - Journal Article
DEP - 20090221
PL  - Netherlands
TA  - Med Health Care Philos
JT  - Medicine, health care, and philosophy
JID - 9815900
SB  - IM
MH  - *Decision Making
MH  - Ethical Theory
MH  - Euthanasia, Active
MH  - Humans
MH  - *Judgment
MH  - Legal Guardians
MH  - *Mental Competency
MH  - *Philosophy, Medical
MH  - Religion
EDAT- 2009/02/24 09:00
MHDA- 2010/03/20 06:00
CRDT- 2009/02/24 09:00
PHST- 2008/10/07 00:00 [received]
PHST- 2009/02/04 00:00 [accepted]
PHST- 2009/02/24 09:00 [entrez]
PHST- 2009/02/24 09:00 [pubmed]
PHST- 2010/03/20 06:00 [medline]
AID - 10.1007/s11019-009-9194-y [doi]
PST - ppublish
SO  - Med Health Care Philos. 2010 Feb;13(1):33-40. doi: 10.1007/s11019-009-9194-y.
      Epub 2009 Feb 21.


PMID- 19222451
OWN - NLM
STAT- MEDLINE
DCOM- 20101102
LR  - 20100617
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 24
IP  - 6
DP  - 2010 Jul
TI  - Publication ethics and the ghost management of medical publication.
PG  - 273-83
LID - 10.1111/j.1467-8519.2008.01702.x [doi]
AB  - It is by now no secret that some scientific articles are ghost authored - that
      is, written by someone other than the person whose name appears at the top of the
      article. Ghost authorship, however, is only one sort of ghosting. In this
      article, we present evidence that pharmaceutical companies engage in the ghost
      management of the scientific literature, by controlling or shaping several
      crucial steps in the research, writing, and publication of scientific articles.
      Ghost management allows the pharmaceutical industry to shape the literature in
      ways that serve its interests. This article aims to reinforce and expand
      publication ethics as an important area of concern for bioethics. Since
      ghost-managed research is primarily undertaken in the interests of marketing,
      large quantities of medical research violate not just publication norms but also 
      research ethics. Much of this research involves human subjects, and yet is
      performed not primarily to increase knowledge for broad human benefit, but to
      disseminate results in the service of profits. Those who sponsor, manage,
      conduct, and publish such research therefore behave unethically, since they put
      patients at risk without justification. This leads us to a strong conclusion: if 
      medical journals want to ensure that the research they publish is ethically
      sound, they should not publish articles that are commercially sponsored.
FAU - Sismondo, Sergio
AU  - Sismondo S
AD  - Department of Philosophy, Queen's University, Kingston, Ontario, Canada.
FAU - Doucet, Mathieu
AU  - Doucet M
LA  - eng
PT  - Journal Article
DEP - 20090216
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
CIN - Bioethics. 2010 Jul;24(6):284-6. PMID: 20497172
MH  - *Authorship
MH  - Codes of Ethics
MH  - Conflict of Interest
MH  - Drug Industry/*ethics/statistics & numerical data
MH  - Editorial Policies
MH  - Ethics, Research
MH  - Federal Government
MH  - Government Regulation
MH  - Guidelines as Topic
MH  - Humans
MH  - Marketing/ethics/statistics & numerical data
MH  - Periodicals as Topic/*ethics/statistics & numerical data
MH  - *Plagiarism
MH  - Publishing/ethics/statistics & numerical data
MH  - Research Support as Topic/ethics/statistics & numerical data
MH  - Scientific Misconduct/*ethics/statistics & numerical data
MH  - *Writing
EDAT- 2009/02/19 09:00
MHDA- 2010/11/03 06:00
CRDT- 2009/02/19 09:00
PHST- 2009/02/19 09:00 [entrez]
PHST- 2009/02/19 09:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - BIOT1702 [pii]
AID - 10.1111/j.1467-8519.2008.01702.x [doi]
PST - ppublish
SO  - Bioethics. 2010 Jul;24(6):273-83. doi: 10.1111/j.1467-8519.2008.01702.x. Epub
      2009 Feb 16.


PMID- 19222449
OWN - NLM
STAT- MEDLINE
DCOM- 20110310
LR  - 20151119
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 24
IP  - 8
DP  - 2010 Oct
TI  - Risk detection in individual health care: any limits?
PG  - 431-8
LID - 10.1111/j.1467-8519.2008.01705.x [doi]
AB  - BACKGROUND: biomedical science is producing an avalanche of data about risk
      factors, often with a small predictive value, associated with a broad diversity
      of diseases. Prevention and screening are increasingly moving from public health 
      into the clinic. Therefore, the question of which risk factors to investigate and
      disclose in the individual patient, becomes ethically increasingly urgent. In
      line with Wilson and Jungner's public health-related 10 principles for screening,
      it seems crucial to distinguish important from unimportant health risks. AIM: to 
      explore the ways in which clinicians distinguish important from unimportant
      health risks. METHODS: we interviewed 36 respondents (gastroenterologists and
      gynaecologists/obstetrics) in 5 focus group interviews and 15 open in-depth
      interviews on their interpretation of what makes a health risk important.
      RESULTS: physicians primarily interpreted importance as the severity of the
      possible harm, less often its probability. Possibilities of prevention or
      reassurance strongly influenced their judgment on importance. DISCUSSION: it is
      not likely that interpreting 'important' as 'severe' will help in differentiating
      meaningful from meaningless risk knowledge. A more fundamental change in our ways
      of dealing with risk may be called for. We discuss existing literature on
      resilience as an alternative way to deal with risk. Balancing prevention and risk
      reduction with resilience could be a fruitful direction.
FAU - Palmboom, Ger
AU  - Palmboom G
AD  - Academic Medical Centre, Meibergdreefis 1105 A2 Amsterdam. gpalmboom@hetnet.nl
FAU - Willems, Dick
AU  - Willems D
LA  - eng
PT  - Journal Article
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Female
MH  - Focus Groups
MH  - Health Promotion/*ethics
MH  - Humans
MH  - Mass Screening/*ethics
MH  - Neoplasms/prevention & control
MH  - Netherlands
MH  - *Practice Patterns, Physicians'
MH  - Pregnancy
MH  - Prenatal Diagnosis/ethics
MH  - *Risk Reduction Behavior
EDAT- 2009/02/19 09:00
MHDA- 2011/03/11 06:00
CRDT- 2009/02/19 09:00
PHST- 2009/02/19 09:00 [entrez]
PHST- 2009/02/19 09:00 [pubmed]
PHST- 2011/03/11 06:00 [medline]
AID - BIOT1705 [pii]
AID - 10.1111/j.1467-8519.2008.01705.x [doi]
PST - ppublish
SO  - Bioethics. 2010 Oct;24(8):431-8. doi: 10.1111/j.1467-8519.2008.01705.x.


PMID- 19222448
OWN - NLM
STAT- MEDLINE
DCOM- 20101102
LR  - 20100617
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 24
IP  - 6
DP  - 2010 Jul
TI  - Profits and plagiarism: the case of medical ghostwriting.
PG  - 267-72
LID - 10.1111/j.1467-8519.2008.00705.x [doi]
AB  - This paper focuses on medical ghostwriting in the United States. I argue that
      medical ghostwriting often involves plagiarism and, in those cases, can be
      treated as an act of research misconduct by both the federal government and
      research institutions. I also propose several anti-ghostwriting measures,
      including: 1) journals should implement guarantor policies so that researchers
      may be better held accountable for their work; 2) research institutions and the
      federal government should explicitly prohibit medical ghostwriting and outline
      appropriate penalties; and 3) a publicly available database should be created to 
      record researchers' ethics violations.
FAU - Anekwe, Tobenna D
AU  - Anekwe TD
AD  - Department of Global Health and Population, Harvard School of Public Health,
      Boston, Massachusetts 02115, USA. tanekwe@hsph.harvard.edu
LA  - eng
PT  - Journal Article
DEP - 20090216
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
CIN - Bioethics. 2010 Jul;24(6):284-6. PMID: 20497172
MH  - Academies and Institutes/ethics
MH  - *Authorship
MH  - Conflict of Interest
MH  - Contract Services/ethics
MH  - Databases, Factual
MH  - Disclosure/ethics
MH  - Drug Industry/ethics
MH  - Editorial Policies
MH  - Federal Government
MH  - Government Regulation
MH  - Guidelines as Topic
MH  - Humans
MH  - Periodicals as Topic/*ethics/statistics & numerical data
MH  - *Plagiarism
MH  - Publishing/ethics/statistics & numerical data
MH  - Scientific Misconduct/*ethics/statistics & numerical data
MH  - United States
MH  - Universities/ethics
MH  - *Writing
EDAT- 2009/02/19 09:00
MHDA- 2010/11/03 06:00
CRDT- 2009/02/19 09:00
PHST- 2009/02/19 09:00 [entrez]
PHST- 2009/02/19 09:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - BIOT705 [pii]
AID - 10.1111/j.1467-8519.2008.00705.x [doi]
PST - ppublish
SO  - Bioethics. 2010 Jul;24(6):267-72. doi: 10.1111/j.1467-8519.2008.00705.x. Epub
      2009 Feb 16.


PMID- 19222447
OWN - NLM
STAT- MEDLINE
DCOM- 20101102
LR  - 20151119
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 24
IP  - 6
DP  - 2010 Jul
TI  - A study of bioethical knowledge and perceptions in Korea.
PG  - 309-22
LID - 10.1111/j.1467-8519.2008.00706.x [doi]
AB  - This study assessed the knowledge and perception of human biological materials
      (HBM) and biorepositories among three study groups in South Korea. The
      relationship between the knowledge and the perception among different groups was 
      also examined by using factor and regression analyses. In a self-reporting survey
      of 440 respondents, the expert group was found more likely to be knowledgeable
      and positively perceived than the others. Four factors emerged: Sale and Consent,
      Flexible Use, Self-Confidence, and Korean Bioethics and Biosafety Action
      restriction perception. The results indicate that those who are well aware of the
      existence of biobanks were more positively inclined to receive the Sale and
      Consent perception. As a result of the need for high quality HBMs and the use of 
      appropriate sampling procedures for every aspect of the collection and use
      process, the biorepository community should pay attention to ethical, legal, and 
      policy issues.
FAU - Park, Young-Joon
AU  - Park YJ
AD  - Department of Pathology, Korea University College of Medicine, South Korea.
FAU - Kim, Sujin
AU  - Kim S
FAU - Kim, Aeree
AU  - Kim A
FAU - Ha, Seung-Yeon
AU  - Ha SY
FAU - Lee, Young-Mee
AU  - Lee YM
FAU - Shin, Bong-Kyung
AU  - Shin BK
FAU - Lee, Hyun-Joo
AU  - Lee HJ
FAU - Park, Soojin
AU  - Park S
FAU - Kim, Han-Kyeom
AU  - Kim HK
LA  - eng
PT  - Journal Article
DEP - 20090216
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Adult
MH  - Advisory Committees
MH  - Analysis of Variance
MH  - *Attitude of Health Personnel
MH  - *Attitude to Health
MH  - Bioethics/education
MH  - Biological Specimen Banks/*ethics/organization & administration
MH  - Codes of Ethics/legislation & jurisprudence
MH  - Commerce/ethics/legislation & jurisprudence
MH  - Confidentiality/ethics/legislation & jurisprudence
MH  - Factor Analysis, Statistical
MH  - Female
MH  - Government Regulation
MH  - Guidelines as Topic
MH  - *Health Knowledge, Attitudes, Practice
MH  - Human Experimentation/ethics/legislation & jurisprudence
MH  - Humans
MH  - Informed Consent/ethics/legislation & jurisprudence
MH  - Male
MH  - Regression Analysis
MH  - Republic of Korea
MH  - Surveys and Questionnaires
EDAT- 2009/02/19 09:00
MHDA- 2010/11/03 06:00
CRDT- 2009/02/19 09:00
PHST- 2009/02/19 09:00 [entrez]
PHST- 2009/02/19 09:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - BIOT706 [pii]
AID - 10.1111/j.1467-8519.2008.00706.x [doi]
PST - ppublish
SO  - Bioethics. 2010 Jul;24(6):309-22. doi: 10.1111/j.1467-8519.2008.00706.x. Epub
      2009 Feb 16.


PMID- 19222445
OWN - NLM
STAT- MEDLINE
DCOM- 20100420
LR  - 20100106
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 24
IP  - 2
DP  - 2010 Feb
TI  - Living to the bitter end? A personalist approach to euthanasia in persons with
      severe dementia.
PG  - 78-86
LID - 10.1111/j.1467-8519.2008.00708.x [doi]
AB  - The number of people suffering from dementia will rise considerably in the years 
      to come. This will have important implications for society. People suffering from
      dementia have to rely on relatives and professional caregivers when their
      disorder progresses. Some people want to determine for themselves their moment of
      death, if they should become demented. They think that the decline in personality
      caused by severe dementia is shocking and unacceptable. In this context, some
      people consider euthanasia as a way to avoid total deterioration. In this
      article, we discuss some practical and ethical dilemmas regarding euthanasia in
      persons with severe dementia based on an advance euthanasia directive. We are
      using a personalist approach in dealing with these ethical dilemmas.
FAU - Gastmans, Chris
AU  - Gastmans C
AD  - Centre for Biomedical Ethics and Law, Faculty of Medicine, Catholic University of
      Leuven, Kapucijnenvoer 35, B-3000 Leuven, Belgium. Chris.Gastmans@med.kuleuven.be
FAU - De Lepeleire, Jan
AU  - De Lepeleire J
LA  - eng
PT  - Journal Article
DEP - 20090210
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Advance Directives/*ethics
MH  - Aged
MH  - *Dementia/psychology/therapy
MH  - Euthanasia/*ethics/legislation & jurisprudence
MH  - Humans
MH  - Personhood
MH  - Quality of Life
MH  - Right to Die/*ethics
MH  - Social Values
EDAT- 2009/02/19 09:00
MHDA- 2010/04/21 06:00
CRDT- 2009/02/19 09:00
PHST- 2009/02/19 09:00 [entrez]
PHST- 2009/02/19 09:00 [pubmed]
PHST- 2010/04/21 06:00 [medline]
AID - BIOT708 [pii]
AID - 10.1111/j.1467-8519.2008.00708.x [doi]
PST - ppublish
SO  - Bioethics. 2010 Feb;24(2):78-86. doi: 10.1111/j.1467-8519.2008.00708.x. Epub 2009
      Feb 10.


PMID- 19222444
OWN - NLM
STAT- MEDLINE
DCOM- 20100714
LR  - 20181201
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 24
IP  - 4
DP  - 2010 May
TI  - Autonomy and ethical treatment in depression.
PG  - 179-89
LID - 10.1111/j.1467-8519.2008.00710.x [doi]
AB  - Antidepressant medication and evidence-based psychotherapy have largely
      equivalent efficacy in the management of the common, less severe grades of
      depression. As a result, several national guidelines recommend that either can be
      used in the treatment of this disorder. Psychotherapy, however, differs in that
      it assists insight into how the depressed person appraises and manages the
      stressors that frequently trigger depressive episodes. I argue that the
      self-knowledge achieved through psychotherapy has moral value in that it promotes
      the autonomy of stressor-related decisions. I further argue that such an effect
      comprises a compelling moral reason for doctors to see evidence-based
      psychotherapy not as merely optional, but as a necessary treatment for their
      patients with depression.
FAU - Biegler, Paul
AU  - Biegler P
AD  - School of Philosophy and Bioethics, Monash University, Clayton, Victoria,
      Australia 3800. pbiegler@bigpond.net.au
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090210
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
RN  - 0 (Antidepressive Agents)
SB  - IM
MH  - Antidepressive Agents/therapeutic use
MH  - Cognitive Behavioral Therapy/ethics
MH  - Decision Making/*ethics
MH  - Depressive Disorder/psychology/*therapy
MH  - Humans
MH  - *Personal Autonomy
MH  - Psychotherapy/*ethics
EDAT- 2009/02/19 09:00
MHDA- 2010/07/16 06:00
CRDT- 2009/02/19 09:00
PHST- 2009/02/19 09:00 [entrez]
PHST- 2009/02/19 09:00 [pubmed]
PHST- 2010/07/16 06:00 [medline]
AID - BIOT710 [pii]
AID - 10.1111/j.1467-8519.2008.00710.x [doi]
PST - ppublish
SO  - Bioethics. 2010 May;24(4):179-89. doi: 10.1111/j.1467-8519.2008.00710.x. Epub
      2009 Feb 10.


PMID- 19222443
OWN - NLM
STAT- MEDLINE
DCOM- 20100714
LR  - 20100409
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 24
IP  - 4
DP  - 2010 May
TI  - Diagnostic self-testing: autonomous choices and relational responsibilities.
PG  - 199-207
LID - 10.1111/j.1467-8519.2008.00711.x [doi]
AB  - Diagnostic self-testing devices are being developed for many illnesses, chronic
      diseases and infections. These will be used in hospitals, at point-of-care
      facilities and at home. Designed to allow earlier detection of diseases,
      self-testing diagnostic devices may improve disease prevention, slow the
      progression of disease and facilitate better treatment outcomes. These devices
      have the potential to benefit both the individual and society by enabling
      individuals to take a more proactive role in the maintenance of their health and 
      by helping society improve health and reduce health costs. However, the full
      implications of future home-based diagnostic technology for individuals and
      society remain unclear due to their novelty. We argue that the development of
      diagnostic tools, especially for home use, will heighten a number of ethical
      challenges. This paper will explore some of the ethical implications of
      home-based self-testing diagnostic devices for the autonomous and relational
      dimensions of the person. This will be facilitated by examining the impact of
      diagnostic devices for individual autonomy, for the delivery of accurate
      diagnosis and for the personal significance of the information for the user. The 
      latter will be examined using Charles Taylor's view of personhood and his
      emphasis on human agency and interpretation. While the ethical issues are not
      necessarily new, the development of home-based self-testing diagnostic devices
      will make issues regarding autonomy, accuracy of information and personal
      significance more and more demanding. This will be the case particularly when an 
      individual's autonomous choices come into conflict with the person's relational
      responsibilities.
FAU - Kearns, Alan J
AU  - Kearns AJ
AD  - Ethics and Moral Theology at the Mater Dei Institute of Education, Dublin.
FAU - O'Mathuna, Donal P
AU  - O'Mathuna DP
FAU - Scott, P Anne
AU  - Scott PA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090210
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
RN  - 0 (Reagent Kits, Diagnostic)
SB  - IM
MH  - Diagnostic Equipment/*ethics
MH  - Ethical Theory
MH  - Humans
MH  - *Personal Autonomy
MH  - Personhood
MH  - Reagent Kits, Diagnostic/*ethics
MH  - Reproducibility of Results
MH  - Self Care/*ethics
MH  - Social Responsibility
EDAT- 2009/02/19 09:00
MHDA- 2010/07/16 06:00
CRDT- 2009/02/19 09:00
PHST- 2009/02/19 09:00 [entrez]
PHST- 2009/02/19 09:00 [pubmed]
PHST- 2010/07/16 06:00 [medline]
AID - BIOT711 [pii]
AID - 10.1111/j.1467-8519.2008.00711.x [doi]
PST - ppublish
SO  - Bioethics. 2010 May;24(4):199-207. doi: 10.1111/j.1467-8519.2008.00711.x. Epub
      2009 Feb 10.


PMID- 19220557
OWN - NLM
STAT- MEDLINE
DCOM- 20110118
LR  - 20100507
IS  - 1445-5994 (Electronic)
IS  - 1444-0903 (Linking)
VI  - 40
IP  - 2
DP  - 2010 Feb
TI  - Enrollment of patients to clinical trials in haematological cancer in New South
      Wales: current status, perceived barriers and opportunities for improvement.
PG  - 133-8
LID - 10.1111/j.1445-5994.2009.01911.x [doi]
AB  - BACKGROUND: Enrolment of cancer patients in clinical trials is associated with
      significant positive outcomes. There are, however, limited Australian data on
      enrolment of patients with haematological malignancies to clinical trials. AIM:
      The aim of this study is to document the number of patients with haematological
      malignancies enrolled on clinical trials in NSW, to establish the barriers to
      trial recruitment and to examine possible means by which clinical trials
      participation may be improved. METHODS: Quantitative data on clinical trial
      accrual were obtained from all sites participating in clinical trials in
      haematological malignancies in NSW from 2004 to 2007 and were compared with the
      cancer incidence data for that period. Qualitative data on barriers and
      strategies for improvement were gathered using semi-structured interviews with
      clinical trials professionals from throughout NSW. RESULTS: Between 2004 and 2007
      there were significant increases in the number of active centres, clinical trials
      and trial participation, and by 2007, 10.5% of all eligible patients with
      haematological malignancies in NSW were enrolled in relevant clinical trials.
      Resource constraints were the greatest perceived barrier to participation, but
      the success of clinical trials is also challenged by difficulties associated with
      communication, ethics review, trial coordination, trial design and support for
      emerging centres. CONCLUSION: While participation in clinical trials in
      haematological cancer in NSW improved between 2004 and 2007, participation in
      clinical trials remains suboptimal. The development of specific strategies to
      address barriers to participation may facilitate increased enrolment and
      ultimately improve clinical outcomes in patients with haematological
      malignancies.
FAU - Murray, P
AU  - Murray P
AD  - Cancer Institute New South Wales, New South Wales, Australia.
      peter.murray@cancerinstitute.org.au
FAU - Kerridge, I
AU  - Kerridge I
FAU - Tiley, C
AU  - Tiley C
FAU - Catanzariti, A
AU  - Catanzariti A
FAU - Welberry, H
AU  - Welberry H
FAU - Lean, C
AU  - Lean C
FAU - Sinclair, S
AU  - Sinclair S
FAU - Bishop, J
AU  - Bishop J
FAU - Bradstock, K
AU  - Bradstock K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
DEP - 20090213
PL  - Australia
TA  - Intern Med J
JT  - Internal medicine journal
JID - 101092952
SB  - IM
MH  - Clinical Trials as Topic/economics/*methods/trends
MH  - *Communication Barriers
MH  - Health Resources/trends
MH  - Hematologic Neoplasms/*epidemiology/*therapy
MH  - Humans
MH  - New South Wales/epidemiology
MH  - *Patient Selection
EDAT- 2009/02/18 09:00
MHDA- 2011/01/19 06:00
CRDT- 2009/02/18 09:00
PHST- 2009/02/18 09:00 [entrez]
PHST- 2009/02/18 09:00 [pubmed]
PHST- 2011/01/19 06:00 [medline]
AID - IMJ1911 [pii]
AID - 10.1111/j.1445-5994.2009.01911.x [doi]
PST - ppublish
SO  - Intern Med J. 2010 Feb;40(2):133-8. doi: 10.1111/j.1445-5994.2009.01911.x. Epub
      2009 Feb 13.


PMID- 19212821
OWN - NLM
STAT- MEDLINE
DCOM- 20100319
LR  - 20211020
IS  - 1572-8633 (Electronic)
IS  - 1386-7423 (Linking)
VI  - 13
IP  - 1
DP  - 2010 Feb
TI  - Rational suicide: philosophical perspectives on schizophrenia.
PG  - 25-31
LID - 10.1007/s11019-009-9183-1 [doi]
AB  - Suicide prevention is a National Health Service priority in the United Kingdom.
      People with mental illness are seen to represent one of the most vulnerable
      groups for suicide and recent British Government policy has focused on prevention
      and management of perceived risk. This approach to suicide prevention is
      constructed under a biomedical model of psychiatry, which maintains that suicidal
      persons suffer from some form of disease or irrational drive towards
      self-destruction. Many react to the idea of self-inflicted death with instinctive
      revulsion, which has prevented serious discussion of the concept of rational
      suicide, particularly in relation to those with schizophrenia. The idea that
      there may be circumstances in which suicide can be viewed as rational is
      discussed within the biomedical approach to ethics and wider literature primarily
      in relation to physical disease, terminal states and chronic pain. It is not
      deemed a viable choice for those who are considered 'non-autonomous' due to the
      controlling forces of mental illness. I propose that suicide is not a consequence
      of mental illness per se, and that it may be seen as a rational response to a
      realistic perspective on the course and consequences of living with
      schizophrenia. The denial of dialogue about the validity of suicidal ideation for
      people with schizophrenia has led to negative consequences for people with
      serious mental illness in terms of justice and recognition of person-hood.
FAU - Hewitt, Jeanette
AU  - Hewitt J
AD  - Department of Philosophy, History and Law, Swansea University, Singleton Park,
      Swansea SA28PP, South Wales, UK. j.l.hewitt@swan.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20090211
PL  - Netherlands
TA  - Med Health Care Philos
JT  - Medicine, health care, and philosophy
JID - 9815900
SB  - IM
MH  - Ethics, Medical
MH  - Humans
MH  - *Philosophy, Medical
MH  - Quality of Life
MH  - *Schizophrenic Psychology
MH  - Suicide/*psychology
EDAT- 2009/02/13 09:00
MHDA- 2010/03/20 06:00
CRDT- 2009/02/13 09:00
PHST- 2008/09/08 00:00 [received]
PHST- 2009/01/22 00:00 [accepted]
PHST- 2009/02/13 09:00 [entrez]
PHST- 2009/02/13 09:00 [pubmed]
PHST- 2010/03/20 06:00 [medline]
AID - 10.1007/s11019-009-9183-1 [doi]
PST - ppublish
SO  - Med Health Care Philos. 2010 Feb;13(1):25-31. doi: 10.1007/s11019-009-9183-1.
      Epub 2009 Feb 11.


PMID- 19210746
OWN - NLM
STAT- MEDLINE
DCOM- 20101102
LR  - 20141120
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 24
IP  - 6
DP  - 2010 Jul
TI  - Elective twin reductions: evidence and ethics.
PG  - 295-303
LID - 10.1111/j.1467-8519.2008.01704.x [doi]
AB  - Twelve years ago the British media got wind of a London gynecologist who
      performed an elective reduction on a twin pregnancy reducing it to a singleton.
      Perhaps not surprisingly, opinion on the moral status of twin reductions was
      divided. But in the last few years new evidence regarding the medical risks of
      twin pregnancies has emerged, suggesting that twin reductions are relevantly
      similar to the reductions performed on high-end multi-fetal pregnancies. This
      evidence has appeared to resolve the moral debate. In this paper I look at the
      role of clinical evidence in medical ethics. In particular I examine the role of 
      clinical evidence in determining what counts as a significant harm or risk.
      First, I challenge the extent to which these empirical claims are descriptive,
      suggesting instead that the evidence is to some degree normative in character.
      Second, I question whether such empirical claims should count as evidence for
      what are essentially difficult ethical decisions - a role they appear to play in 
      the case of elective reductions. I will argue that they should not, primarily
      because the value-laden nature of this evidence conceals much of what is
      ethically at stake. It is important to recognize that empirical evidence cannot
      be a substitute for ethical deliberation.
FAU - McClimans, Leah
AU  - McClimans L
AD  - Department of Philosophy, University of South Carolina, Columbia, South Carolina 
      29208, USA. mccliman@gwm.sc.edu
LA  - eng
PT  - Journal Article
DEP - 20090208
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Congenital Abnormalities/diagnosis/prevention & control
MH  - Dissent and Disputes
MH  - Elective Surgical Procedures/*ethics
MH  - Evidence-Based Practice/*ethics
MH  - Female
MH  - Humans
MH  - Intention
MH  - Moral Obligations
MH  - Obstetrics/ethics
MH  - Physician's Role
MH  - Pregnancy
MH  - Pregnancy Outcome/epidemiology
MH  - Pregnancy Reduction, Multifetal/*ethics
MH  - Reproductive Techniques, Assisted/ethics
MH  - Risk Assessment/ethics
MH  - *Twins
EDAT- 2009/02/13 09:00
MHDA- 2010/11/03 06:00
CRDT- 2009/02/13 09:00
PHST- 2009/02/13 09:00 [entrez]
PHST- 2009/02/13 09:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - BIOT1704 [pii]
AID - 10.1111/j.1467-8519.2008.01704.x [doi]
PST - ppublish
SO  - Bioethics. 2010 Jul;24(6):295-303. doi: 10.1111/j.1467-8519.2008.01704.x. Epub
      2009 Feb 8.


PMID- 19208613
OWN - NLM
STAT- MEDLINE
DCOM- 20100902
LR  - 20220311
IS  - 1471-8391 (Electronic)
IS  - 0007-1420 (Linking)
VI  - 93
DP  - 2010
TI  - Genetics and sports.
PG  - 27-47
LID - 10.1093/bmb/ldp007 [doi]
AB  - INTRODUCTION: The limit of each individual to perform a given type of exercise
      depends on the nature of the task, and is influenced by a variety of factors,
      including psychology, environment and genetic make up. Genetics provide useful
      insights, as sport performances can be ultimately defined as a polygenic trait.
      SOURCES OF DATA: We searched PubMed using the terms 'sports' and 'genetics' over 
      the period 1990 to present. AREAS OF AGREEMENT: The physical performance
      phenotypes for which a genetic basis can be suspected include endurance capacity,
      muscle performance, physiological attitude to train and ability of tendons and
      ligaments to withstand injury. Genetic testing in sport would permit to identify 
      individuals with optimal physiology and morphology, and also those with a greater
      capacity to respond/adapt to training and a lesser chance of suffering from
      injuries. AREAS OF CONTROVERSY: Ethical and practical caveats should be clearly
      emphasized. The translation of an advantageous genotype into a champion's
      phenotype is still influenced by environmental, psychological and sociological
      factors. EMERGING AREAS FOR DEVELOPING RESEARCH: The current scientific evidence 
      on the relationship between genetics and sports look promising. There is a need
      for additional studies to determine whether genome-wide genotyping arrays would
      be really useful and cost-effective. Since exercise training regulates the
      expression of genes encoding various enzymes in muscle and other tissues, genetic
      research in sports will help clarify several aspects of human biology and
      physiology, such as RNA and protein level regulation under specific
      circumstances.
FAU - Lippi, Giuseppe
AU  - Lippi G
AD  - Sezione di Chimica Clinica, Universita di Verona, Italy.
FAU - Longo, Umile Giuseppe
AU  - Longo UG
FAU - Maffulli, Nicola
AU  - Maffulli N
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20090209
PL  - England
TA  - Br Med Bull
JT  - British medical bulletin
JID - 0376542
SB  - IM
MH  - Athletic Performance/*physiology/psychology
MH  - Genetic Testing/*ethics
MH  - Genotype
MH  - Humans
MH  - Motor Skills/physiology
MH  - Phenotype
MH  - Physical Endurance/*genetics
RF  - 100
EDAT- 2009/02/12 09:00
MHDA- 2010/09/03 06:00
CRDT- 2009/02/12 09:00
PHST- 2009/02/12 09:00 [entrez]
PHST- 2009/02/12 09:00 [pubmed]
PHST- 2010/09/03 06:00 [medline]
AID - ldp007 [pii]
AID - 10.1093/bmb/ldp007 [doi]
PST - ppublish
SO  - Br Med Bull. 2010;93:27-47. doi: 10.1093/bmb/ldp007. Epub 2009 Feb 9.


PMID- 19184442
OWN - NLM
STAT- MEDLINE
DCOM- 20111122
LR  - 20211020
IS  - 1573-3394 (Electronic)
IS  - 1065-3058 (Linking)
VI  - 18
IP  - 1
DP  - 2010 Mar
TI  - Compensated living kidney donation: a plea for pragmatism.
PG  - 85-101
LID - 10.1007/s10728-008-0110-z [doi]
AB  - Kidney transplantation is the most efficacious and cost-effective treatment for
      end-stage renal disease. However, the treatment's accessibility is limited by a
      chronic shortage of transplantable kidneys, resulting in the death of numerous
      patients worldwide as they wait for a kidney to become available. Despite the
      implementation of various measures the disparity between supply and needs
      continues to grow. This paper begins with a look at the current treatment
      options, including various sources of transplantable kidneys, for end-stage renal
      disease. We propose, in accordance with others, the introduction of compensated
      kidney donation as a means of addressing the current shortage. We briefly outline
      some of the advantages of this proposal, and then turn to examine several of the 
      ethical arguments usually marshaled against it in a bid to demonstrate that this 
      proposal indeed passes the ethics test. Using available data of public opinions
      on compensated donation, we illustrate that public support for such a program
      would be adequate enough that we can realistically eliminate the transplant
      waiting list if compensation is introduced. We urge a pragmatic approach going
      forward; altruism in living kidney donation is important, but altruism only is an
      unsuccessful doctrine.
FAU - Omar, Faisal
AU  - Omar F
AD  - Division of Health and Society, Department of Medical and Health Sciences,
      Linkoping University, Linkoping, Sweden. faisal.omar@liu.se
FAU - Tufveson, Gunnar
AU  - Tufveson G
FAU - Welin, Stellan
AU  - Welin S
LA  - eng
PT  - Journal Article
DEP - 20090129
PL  - Netherlands
TA  - Health Care Anal
JT  - Health care analysis : HCA : journal of health philosophy and policy
JID - 9432537
MH  - Altruism
MH  - Compensation and Redress/*ethics
MH  - Humans
MH  - Kidney Failure, Chronic/*surgery
MH  - Kidney Transplantation/economics/*ethics
MH  - Living Donors/*ethics
MH  - Tissue and Organ Procurement/ethics
EDAT- 2009/02/03 09:00
MHDA- 2011/12/13 00:00
CRDT- 2009/02/03 09:00
PHST- 2008/10/20 00:00 [received]
PHST- 2008/12/16 00:00 [accepted]
PHST- 2009/02/03 09:00 [entrez]
PHST- 2009/02/03 09:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/s10728-008-0110-z [doi]
PST - ppublish
SO  - Health Care Anal. 2010 Mar;18(1):85-101. doi: 10.1007/s10728-008-0110-z. Epub
      2009 Jan 29.


PMID- 19181502
OWN - NLM
STAT- MEDLINE
DCOM- 20100419
LR  - 20181201
IS  - 1618-1433 (Electronic)
IS  - 0940-2993 (Linking)
VI  - 62
IP  - 1
DP  - 2010 Jan
TI  - The age- and gender-dependent effects of desflurane and sevoflurane on rat liver.
PG  - 35-43
LID - 10.1016/j.etp.2008.12.011 [doi]
AB  - OBJECTIVE: This study aimed to investigate the age- and gender-dependent effects 
      of desflurane and sevoflurane on the liver. MATERIAL AND METHOD: Upon the
      approval of ethics committee, 84 rats were divided into four groups as 21 young
      male, 21 young female, 21 old male, and 21 old female rats. Then, each group was 
      further divided into three groups as desflurane, sevoflurane, and control groups.
      Maintaining the minimum alveolar concentration of 1, desflurane at 6vol% and
      sevoflurane at 2vol% in 6Lmin(-1) 100% O2 were administered for 2h in a
      transparent plastic container of 40cmx40cmx70cm. Each liver preparation was
      evaluated for hydropic degeneration, nuclear polymorphism, portal neutrophile
      infiltration, portal lymphocyte infiltration, and focal necrosis, and each
      preparation was assigned injury points of 0-3; thus, the number of
      histopathologically injured cases, total injury scores of each preparation, and
      the mean injury scores of each group were determined. RESULTS: Desflurane and
      sevoflurane did not significantly increase hepatic injury in the young male rats,
      while both agents caused significantly more hepatic injury in the young female
      rats. In the old rats, both desflurane and sevoflurane inflicted more hepatic
      injury on both genders. In addition, desflurane caused more hepatic injury in the
      old female rats than in the young female or the old male rats. CONCLUSION:
      Hepatic injury associated with desflurane and sevoflurane was mild to moderate,
      suggesting that both agents can be safely used in routine anaesthesia procedures.
CI  - Copyright 2009 Elsevier GmbH. All rights reserved.
FAU - Arslan, M
AU  - Arslan M
AD  - Department of Anaesthesiology and Reanimation, Gazi University School of
      Medicine, Ankara, Turkey. mustarslan@gmail.com
FAU - Ozkose, Z
AU  - Ozkose Z
FAU - Akyol, G
AU  - Akyol G
FAU - Barit, G
AU  - Barit G
LA  - eng
PT  - Journal Article
DEP - 20090131
PL  - Germany
TA  - Exp Toxicol Pathol
JT  - Experimental and toxicologic pathology : official journal of the Gesellschaft fur
      Toxikologische Pathologie
JID - 9208920
RN  - 0 (Anesthetics, Inhalation)
RN  - 0 (Methyl Ethers)
RN  - 38LVP0K73A (Sevoflurane)
RN  - CRS35BZ94Q (Desflurane)
RN  - CYS9AKD70P (Isoflurane)
SB  - IM
MH  - Age Factors
MH  - Anesthetics, Inhalation/*pharmacology
MH  - Animals
MH  - Desflurane
MH  - Female
MH  - Isoflurane/*analogs & derivatives/pharmacology
MH  - Liver/anatomy & histology/*drug effects
MH  - Male
MH  - Methyl Ethers/*pharmacology
MH  - Neutrophil Infiltration/drug effects
MH  - Rats
MH  - Sevoflurane
MH  - Sex Factors
EDAT- 2009/02/03 09:00
MHDA- 2010/04/20 06:00
CRDT- 2009/02/03 09:00
PHST- 2008/09/17 00:00 [received]
PHST- 2008/12/10 00:00 [revised]
PHST- 2008/12/30 00:00 [accepted]
PHST- 2009/02/03 09:00 [entrez]
PHST- 2009/02/03 09:00 [pubmed]
PHST- 2010/04/20 06:00 [medline]
AID - S0940-2993(09)00003-7 [pii]
AID - 10.1016/j.etp.2008.12.011 [doi]
PST - ppublish
SO  - Exp Toxicol Pathol. 2010 Jan;62(1):35-43. doi: 10.1016/j.etp.2008.12.011. Epub
      2009 Jan 31.


PMID- 21029488
OWN - NLM
STAT- MEDLINE
DCOM- 20101207
LR  - 20101222
IS  - 1876-8784 (Electronic)
IS  - 0028-2162 (Linking)
VI  - 154
DP  - 2010
TI  - [Dutch government invests in existing biobanks].
PG  - A2825
AB  - Modern research, aimed at discovering factors that influence health and disease, 
      requires large collections of data and samples. Collaboration between biobanks is
      therefore essential. The Dutch hub in the network of biobanks, the Biobanking and
      Biomolecular Resources Research Infrastructure (BBMRI-NL), is one of the major
      Dutch biobanking initiatives. It is sponsored by the Dutch government through the
      Netherlands Organization for Scientific Research (NWO). BBMRI-NL sets up
      collaboration between approximately 150 existing clinical and population biobanks
      in the Netherlands, and forms the link with the European BBMRI initiative.
      BBMRI-NL aims at enrichment and harmonization of existing Dutch biobanks, at data
      management and analysis, and at laying the legal, social and ethical foundations,
      in order to improve access and inter-operability, and to render the information
      and organization up to date. Other major Dutch initiatives are String of Pearls
      and LifeLines. Together these will create the conditions needed for Dutch
      researchers to further develop their strong position in the international
      biobanking field.
FAU - Brandsma, Margreet
AU  - Brandsma M
AD  - Leids Universitair Medisch Centrum, Afd. Humane Genetica, Leiden, the
      Netherlands. m.brandsma@lumc.nl
FAU - van Ommen, Gert-Jan B
AU  - van Ommen GJ
FAU - Wijmenga, Cisca
AU  - Wijmenga C
FAU - Kiemeney, Lambertus A
AU  - Kiemeney LA
LA  - dut
PT  - English Abstract
PT  - Journal Article
TT  - Overheid investeert fors in bestaande biobanken.
PL  - Netherlands
TA  - Ned Tijdschr Geneeskd
JT  - Nederlands tijdschrift voor geneeskunde
JID - 0400770
SB  - IM
MH  - Biomedical Research/ethics/trends
MH  - Financing, Government
MH  - Humans
MH  - Netherlands
MH  - *Personal Autonomy
MH  - *Tissue Banks/economics/ethics/organization & administration/trends
EDAT- 2009/01/01 00:00
MHDA- 2010/12/14 06:00
CRDT- 2010/10/30 06:00
PHST- 2010/10/30 06:00 [entrez]
PHST- 2009/01/01 00:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - Ned Tijdschr Geneeskd. 2010;154:A2825.


PMID- 21029487
OWN - NLM
STAT- MEDLINE
DCOM- 20101207
LR  - 20101222
IS  - 1876-8784 (Electronic)
IS  - 0028-2162 (Linking)
VI  - 154
DP  - 2010
TI  - [Whole genome sequencing--new opportunities for health care practice?].
PG  - A2753
AB  - In the near future it will probably be possible to unravel the DNA code of the
      human genome for less than US $ 1,000 by means of 'whole genome sequencing'
      (WGS). However, its usefulness in clinical practice is questionable. Although WGS
      of an individual may become relatively inexpensive and easily available,
      knowledge of the complete DNA sequence in itself does not provide clinically
      useful information. DNA data need to be analyzed and interpreted, but there are
      still many gaps and uncertainties in our knowledge of DNA variations and their
      clinical consequences. WGS may be a useful supplementary testing technique for
      establishing the diagnosis of monogenic disorders and syndromes, but potentially 
      undesirable or unclear findings may cause ethical and practical problems.
      Therefore, WGS should only be applied very cautiously and after thorough
      deliberation of its possible consequences.
FAU - de Jong, Antina
AU  - de Jong A
AD  - Universiteit Maastricht, Faculteit Health, Medicine and Life Sciences, afd.
      Metamedica, Maastricht, the Netherlands. secretaris@nacgg.nl
FAU - Teeuw, Marieke
AU  - Teeuw M
FAU - Janssens, A Cecile J W
AU  - Janssens AC
LA  - dut
PT  - English Abstract
PT  - Journal Article
TT  - 'Whole genome sequencing'--nieuwe mogelijkheden voor de gezondheidszorg?
PL  - Netherlands
TA  - Ned Tijdschr Geneeskd
JT  - Nederlands tijdschrift voor geneeskunde
JID - 0400770
SB  - IM
MH  - Base Sequence
MH  - *Chromosome Mapping
MH  - Ethics, Clinical
MH  - *Genome, Human
MH  - Humans
MH  - Sequence Analysis, DNA/*economics
EDAT- 2009/01/01 00:00
MHDA- 2010/12/14 06:00
CRDT- 2010/10/30 06:00
PHST- 2010/10/30 06:00 [entrez]
PHST- 2009/01/01 00:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
PST - ppublish
SO  - Ned Tijdschr Geneeskd. 2010;154:A2753.


PMID- 20977808
OWN - NLM
STAT- MEDLINE
DCOM- 20101115
LR  - 20101116
IS  - 1876-8784 (Electronic)
IS  - 0028-2162 (Linking)
VI  - 154
DP  - 2010
TI  - [Practice guideline on extremely premature birth: too little room for parents to 
      decide].
PG  - A2761
AB  - The new practice guideline on the treatment of extremely premature infants is
      discussed. The guideline advises to actively treat all children born after 24 0/7
      weeks of gestation. Although there is some evidence supporting this view, it is
      argued that the guideline is incomplete as decisions about the treatment of such 
      newborn infants can only be made after discussion with the parents. The guideline
      should also have taken into account the ethical and legal aspects of the issue.
      It is therefore concluded that the guideline itself is immature and premature.
FAU - van Delden, J J M Hans
AU  - van Delden JJ
AD  - Universitair Medisch Centrum Utrecht, Julius Centrum voor
      Gezondheidswetenschappen en Eerstelijns Geneeskunde, Utrecht, the Netherlands.
      j.j.m.vandelden@umcutrecht.nl
LA  - dut
PT  - English Abstract
PT  - Journal Article
TT  - Richtlijn extreme vroeggeboorte is prematuur en dysmatuur.
PL  - Netherlands
TA  - Ned Tijdschr Geneeskd
JT  - Nederlands tijdschrift voor geneeskunde
JID - 0400770
SB  - IM
MH  - Decision Making
MH  - *Ethics, Medical
MH  - Female
MH  - Gestational Age
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Premature/*growth & development
MH  - Infant, Premature, Diseases/*therapy
MH  - Parents/*psychology
MH  - Perinatal Mortality
MH  - *Practice Guidelines as Topic
MH  - Pregnancy
MH  - Premature Birth/prevention & control
EDAT- 2009/01/01 00:00
MHDA- 2010/11/16 06:00
CRDT- 2010/10/28 06:00
PHST- 2010/10/28 06:00 [entrez]
PHST- 2009/01/01 00:00 [pubmed]
PHST- 2010/11/16 06:00 [medline]
PST - ppublish
SO  - Ned Tijdschr Geneeskd. 2010;154:A2761.


PMID- 20543455
OWN - NLM
STAT- MEDLINE
DCOM- 20100913
LR  - 20220408
IS  - 1875-8584 (Electronic)
IS  - 0953-4180 (Linking)
VI  - 22
IP  - 1-2
DP  - 2010
TI  - Rose-colored answers: neuropsychological deficits and patient-reported outcomes
      after stroke.
PG  - 17-23
LID - 10.3233/BEN-2009-0250 [doi]
AB  - Patient-reported, subjective outcomes are promoted as a standard for ethical,
      valid studies in many neurological disorders. Such outcomes are considered
      potentially more sensitive and specific to important therapeutic effects, and may
      be more linked to disability and disease-related life losses than conventional
      assessments of impairment (e.g. ability to walk, performance on language tests,
      serological or radiological indices). Self-report is invaluable to identify
      social and emotional consequences of brain injury: depression, changes in
      intimate and family relationships, social role and community participation
      losses. However, common stroke-related neuropsychological deficits are likely to 
      confound subjective stroke outcome measures. The scientific community focused on 
      stroke-related health outcomes may arrive at {significantly underestimated}
      patient reports of stroke-related disability, caused by a failure to adjust for
      the effect on self-report of spatial neglect, deficits of magnitude estimation,
      pathologic alteration of self-awareness, and alteration in distributed cortical
      systems supporting emotional semantics and abstraction.
FAU - Barrett, Anna M
AU  - Barrett AM
AD  - Stroke Rehabilitation Research, Kessler Foundation Research Center, West Orange, 
      NJ 07052, USA. abarrett@kesslerfoundation.org
LA  - eng
GR  - R01 NS055808-02/NS/NINDS NIH HHS/United States
GR  - 5R01NS055808-02/NS/NINDS NIH HHS/United States
GR  - R01 NS055808/NS/NINDS NIH HHS/United States
GR  - 5K02NS047099-06/NS/NINDS NIH HHS/United States
GR  - K02 NS047099-06/NS/NINDS NIH HHS/United States
GR  - K02 NS047099/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Behav Neurol
JT  - Behavioural neurology
JID - 8914585
SB  - IM
MH  - Cognition Disorders/etiology/*psychology
MH  - Humans
MH  - Language Disorders/etiology/*psychology
MH  - Paresis/etiology/psychology
MH  - Perceptual Disorders/etiology/*psychology
MH  - Quality of Life
MH  - *Self-Assessment
MH  - Stroke/complications/*psychology
RF  - 41
PMC - PMC2908323
MID - NIHMS218713
EDAT- 2009/01/01 00:00
MHDA- 2010/09/14 06:00
CRDT- 2010/06/15 06:00
PHST- 2010/06/15 06:00 [entrez]
PHST- 2009/01/01 00:00 [pubmed]
PHST- 2010/09/14 06:00 [medline]
AID - 32U87V177X1P5113 [pii]
AID - 10.3233/BEN-2009-0250 [doi]
PST - ppublish
SO  - Behav Neurol. 2010;22(1-2):17-23. doi: 10.3233/BEN-2009-0250.


PMID- 19076119
OWN - NLM
STAT- MEDLINE
DCOM- 20100420
LR  - 20100118
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 24
IP  - 2
DP  - 2010 Feb
TI  - Ethical debate over organ donation in the context of brain death.
PG  - 54-60
LID - 10.1111/j.1467-8519.2008.00690.x [doi]
AB  - This study investigated what information about brain death was available from
      Google searches for five major religions. A substantial body of supporting
      research examining online behaviors shows that information seekers use Google as 
      their preferred search engine and usually limit their search to entries on the
      first page. For each of the five religions in this study, Google listings reveal 
      ethical controversy about organ donation in the context of brain death. These
      results suggest that family members who go online to find information about organ
      donation in the context of brain death would find information about ethical
      controversy in the first page of Google listings. Organ procurement agencies
      claim that all major world religions approve of organ donation and do not address
      the ethical controversy about organ donation in the context of brain death that
      is readily available online.
FAU - Bresnahan, Mary Jiang
AU  - Bresnahan MJ
AD  - Department of Communication, Michigan State University, East Lasning, Michigan
      48824-1212, USA. bresnah1@msu.edu
FAU - Mahler, Kevin
AU  - Mahler K
LA  - eng
PT  - Journal Article
DEP - 20091205
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - *Attitude to Health
MH  - *Brain Death
MH  - Buddhism
MH  - Catholicism
MH  - *Consumer Health Information
MH  - Hinduism
MH  - Humans
MH  - *Internet
MH  - Islam
MH  - Judaism
MH  - *Religion and Medicine
MH  - Search Engine
MH  - Tissue and Organ Procurement/*ethics
EDAT- 2008/12/17 09:00
MHDA- 2010/04/21 06:00
CRDT- 2008/12/17 09:00
PHST- 2008/12/17 09:00 [entrez]
PHST- 2008/12/17 09:00 [pubmed]
PHST- 2010/04/21 06:00 [medline]
AID - BIOT690 [pii]
AID - 10.1111/j.1467-8519.2008.00690.x [doi]
PST - ppublish
SO  - Bioethics. 2010 Feb;24(2):54-60. doi: 10.1111/j.1467-8519.2008.00690.x. Epub 2009
      Dec 5.


PMID- 19055559
OWN - NLM
STAT- MEDLINE
DCOM- 20100426
LR  - 20100208
IS  - 1439-0531 (Electronic)
IS  - 0936-6768 (Linking)
VI  - 45
IP  - 1
DP  - 2010 Feb
TI  - Technical aspects of laparoscopic ovarian autograft in ewes after
      cryopreservation by slow-cooling protocol.
PG  - 8-12
LID - 10.1111/j.1439-0531.2008.01126.x [doi]
AB  - Iatrogenic ovarian failure and infertility are long term-term side effects of
      anticancerous gonadotoxic treatments in children or women of reproductive year.
      Ovarian cortex cryopreservation can be a solution to preserve immature germinal
      cells before gonadotoxic treatment, for later transplantation. The aim of our
      study was to prove the efficiency of a laparoscopic technique for orthotopic
      graft after a slow-freezing/thawing protocol, and to evaluate the effect of
      ovarian cryopreservation and autograft on the primordial follicle survival rate. 
      Experimental surgical study was performed on 6- to 12-month-old ewes. The study
      was approved by the ethic committee of the Lyon-veterinary-school. The left ovary
      was removed by laparoscopy and cut in half, and medulla was excised. In group 1
      (n = 6), autograft was performed immediately on the right ovary, and in group 2
      (n = 6), graft was performed after a slow-freezing/thawing protocol. The second
      hemi-ovary served as an ungrafted control fragment. A polypropylene/polyglactin
      mesh was included between graft and base to separate the two structures, to help 
      histological analysis. The mean graft performance time was 71 +/- 8 min in the
      first group and 57 +/- 10 min in the second. Freezing did not affect the number
      of primordial follicles. In the ungraft control fragments, the global anomaly
      rate (cytoplasm plus nuclear anomaly) increased after freezing (p < 0.05). Others
      results did not reach signification. Pelvic adhesion occurred only once. The
      post-graft primordial follicle survival rate was 5.1 +/- 2.8% in the non-frozen
      group vs. 6.3 +/- 2.3% after freezing/thawing. Kruskal-Wallis and Wilkoxon
      non-parametric tests were used for statistical analysis. Laparoscopy seems to be 
      a well-adapted technique for ovarian tissue orthotopic autograft. The main
      follicle loss occurs before graft revascularization. Our orthotopic graft's
      procedure has to be improved to obtain a better graft's neovascularization, and
      to have a better long-term post-graft primordial follicle survival rate.
FAU - Massardier, J
AU  - Massardier J
AD  - Hospices Civils de Lyon, Departement de Medecine de la Reproduction, Pr. Guerin, 
      Lyon, France. jerome.massardier@chu-lyon.fr
FAU - Courbiere, B
AU  - Courbiere B
FAU - Lornage, J
AU  - Lornage J
FAU - Mazoyer, C
AU  - Mazoyer C
FAU - Poirel, M T
AU  - Poirel MT
FAU - Martinot, S
AU  - Martinot S
FAU - Franck, M
AU  - Franck M
FAU - Salle, B
AU  - Salle B
LA  - eng
PT  - Journal Article
DEP - 20081128
PL  - Germany
TA  - Reprod Domest Anim
JT  - Reproduction in domestic animals = Zuchthygiene
JID - 9015668
SB  - IM
MH  - Animals
MH  - Cryopreservation/methods/*veterinary
MH  - Female
MH  - Laparoscopy/*veterinary
MH  - Ovarian Follicle/anatomy & histology/physiology
MH  - Ovary/physiology/*transplantation
MH  - *Sheep
MH  - Transplantation, Autologous/veterinary
MH  - Transplantation, Heterotopic/veterinary
EDAT- 2008/12/06 09:00
MHDA- 2010/04/27 06:00
CRDT- 2008/12/06 09:00
PHST- 2008/12/06 09:00 [pubmed]
PHST- 2010/04/27 06:00 [medline]
PHST- 2008/12/06 09:00 [entrez]
AID - RDA1126 [pii]
AID - 10.1111/j.1439-0531.2008.01126.x [doi]
PST - ppublish
SO  - Reprod Domest Anim. 2010 Feb;45(1):8-12. doi: 10.1111/j.1439-0531.2008.01126.x.
      Epub 2008 Nov 28.


PMID- 19028732
OWN - NLM
STAT- MEDLINE
DCOM- 20110701
LR  - 20131121
IS  - 1473-0480 (Electronic)
IS  - 0306-3674 (Linking)
VI  - 44
IP  - 9
DP  - 2010 Jul
TI  - A 12-week aerobic training programme reduced plasmatic allantoin in adolescents
      with Down syndrome.
PG  - 685-7
LID - 10.1136/bjsm.2008.052530 [doi]
AB  - OBJECTIVE: To assess the influence of a 12-week training programme on plasmatic
      levels of allantoin, an in vivo marker for oxidative stress, in adolescents with 
      Down syndrome. This finding would be of great interest, since oxidative damage
      has been proposed as a pathogenic mechanism of several pathologies in this
      population. MATERIALS: To reach this goal, 31 male adolescents with Down syndrome
      (16.3 (1.1) years; 155.2 (5.7) cm; 70.8 (4.5) kg) performed a 12-week training
      programme, three sessions per week, consisting of warm-up (15 min) followed by a 
      main part (20-35 min (increasing 5 min each 3 weeks)) at a work intensity of
      60-75% of peak heart rate (increasing by 5% each 3 weeks) and then a cool-down
      period (10 min). According to previous studies, it should be emphasised that the 
      maximal heart rate for individuals with Down syndrome was predicted by the
      equation HRmax = 194.5-(0.56 age). The control group included seven age-, sex-
      and BMI-matched adolescents with trisomy 21 that did not perform any training
      programme. The levels uric acid and allantoin were assayed in plasma by HPLC.
      This protocol was approved by an institutional ethics committee. RESULTS: When
      compared with baseline, plasmatic levels of allantoin were decreased
      significantly (22.09 (1.62) vs 18.74 (1.38) micromol/l; p<0.001) after being
      exercised. Furthermore, the allantoin/uric acid ratio was decreased significantly
      (0.071 (0.006) vs 0.059 (0.004); p<0.05). On the contrary, no changes were
      reported in controls. CONCLUSION: A 12-week aerobic programme significantly
      reduced oxidative damage expressed in terms of plasmatic allantoin content in
      adolescents with Down syndrome. Further studies on this topic are required.
FAU - Rosety-Rodriguez, M
AU  - Rosety-Rodriguez M
AD  - Puerto Real University Hospital, University of Cadiz, Cadiz, Spain.
FAU - Rosety, I
AU  - Rosety I
FAU - Fornieles-Gonzalez, G
AU  - Fornieles-Gonzalez G
FAU - Diaz, A
AU  - Diaz A
FAU - Rosety, M
AU  - Rosety M
FAU - Ordonez, F J
AU  - Ordonez FJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20081121
PL  - England
TA  - Br J Sports Med
JT  - British journal of sports medicine
JID - 0432520
RN  - 268B43MJ25 (Uric Acid)
RN  - 344S277G0Z (Allantoin)
SB  - IM
MH  - Adolescent
MH  - Allantoin/*blood
MH  - Case-Control Studies
MH  - Down Syndrome/blood/*therapy
MH  - Exercise/*physiology
MH  - Exercise Therapy/*methods
MH  - Humans
MH  - Male
MH  - Uric Acid/blood
EDAT- 2008/11/26 09:00
MHDA- 2011/07/02 06:00
CRDT- 2008/11/26 09:00
PHST- 2008/11/26 09:00 [pubmed]
PHST- 2011/07/02 06:00 [medline]
PHST- 2008/11/26 09:00 [entrez]
AID - bjsm.2008.052530 [pii]
AID - 10.1136/bjsm.2008.052530 [doi]
PST - ppublish
SO  - Br J Sports Med. 2010 Jul;44(9):685-7. doi: 10.1136/bjsm.2008.052530. Epub 2008
      Nov 21.


PMID- 19015986
OWN - NLM
STAT- MEDLINE
DCOM- 20101108
LR  - 20211020
IS  - 1557-1920 (Electronic)
IS  - 1557-1912 (Linking)
VI  - 12
IP  - 4
DP  - 2010 Aug
TI  - The neglect of racism as an ethical issue in health care.
PG  - 489-95
LID - 10.1007/s10903-008-9210-y [doi]
AB  - Race and racism has been increasingly implicated in known disparities in the
      health and health care of racial, ethnic and cultural minorities groups. Despite 
      the obvious ethical implications of this observation, racism as an ethical issue 
      per se has been relatively neglected in health care ethics discourse. In this
      paper consideration is given to addressing the following questions: What is it
      about racism and racial disparities in health and health care that these command 
      our special moral scrutiny? Why has racism per se tended to be poorly addressed
      as an ethical issue in health care ethics discourse? And why, if at all, must
      racism be addressed as an ethical issue in addition to its positioning as a
      social, political, cultural and legal issue? It is suggested that unless racism
      is reframed and redressed as a pre-eminent ethical issue by health service
      providers, its otherwise preventable harmful consequences will remain difficult
      to identify, anticipate, prevent, manage, and remedy.
FAU - Johnstone, Megan-Jane
AU  - Johnstone MJ
AD  - School of Nursing, Faculty of Health, Medicine, Nursing and Behavioural Sciences,
      Deakin University, 221 Burwood Highway, Burwood, Melbourne, VIC 3125, Australia. 
      megan.johnstone@deakin.edu.au
FAU - Kanitsaki, Olga
AU  - Kanitsaki O
LA  - eng
PT  - Journal Article
DEP - 20081118
PL  - United States
TA  - J Immigr Minor Health
JT  - Journal of immigrant and minority health
JID - 101256527
SB  - IM
MH  - Delivery of Health Care/*ethics
MH  - Healthcare Disparities/ethics
MH  - Humans
MH  - *Prejudice
EDAT- 2008/11/19 09:00
MHDA- 2010/11/09 06:00
CRDT- 2008/11/19 09:00
PHST- 2008/07/29 00:00 [received]
PHST- 2008/11/04 00:00 [accepted]
PHST- 2008/11/19 09:00 [pubmed]
PHST- 2010/11/09 06:00 [medline]
PHST- 2008/11/19 09:00 [entrez]
AID - 10.1007/s10903-008-9210-y [doi]
PST - ppublish
SO  - J Immigr Minor Health. 2010 Aug;12(4):489-95. doi: 10.1007/s10903-008-9210-y.
      Epub 2008 Nov 18.


PMID- 18992923
OWN - NLM
STAT- MEDLINE
DCOM- 20100419
LR  - 20100129
IS  - 1532-866X (Electronic)
IS  - 0049-0172 (Linking)
VI  - 39
IP  - 4
DP  - 2010 Feb
TI  - Lupus registries: evolution and challenges.
PG  - 224-45
LID - 10.1016/j.semarthrit.2008.08.009 [doi]
AB  - OBJECTIVES: To review the current status of lupus registries, highlight the
      importance and evolution of registries in clinical lupus research, discuss
      substantial advances in the understanding of lupus through the use of registries,
      and discuss the future role of registries in terms of opportunities and
      challenges. METHODS: The literature reviewed originated from the PubMed database 
      and was limited to adult disease in articles published before June 01, 2008.
      Keywords used in the PubMed search included the following terms: systemic lupus
      erythematosus, registry, cohort, and database. All articles were sorted and
      analyzed according to a template devised by the authors describing the different 
      types of registries. RESULTS: The most important features of a lupus registry are
      that they contain a large number of subjects and reflect a relatively real world 
      environment for lupus patients. Data obtained from the lupus registries are
      essential for planning, designing, and conducting clinical lupus studies,
      especially those difficult, inappropriate, or even unethical to study in
      randomized controlled trials. Up to now, some well-conducted registries have
      received recognition for their contributions to lupus research through their
      focus on different goals: epidemiology, genetics, ethnic diversity, clinical
      features, or outcomes. Although they have evolved in design and study emphasis
      steadily, there are still many issues left to resolve. Apart from the development
      and future direction of the lupus registry, attention needs to be applied to
      normalizing the ethical and legal rules involving a lupus registry. CONCLUSIONS: 
      Lupus registries have demonstrated high standards and achieved much success
      through decades of effort, but they are still in an active state of evolution as 
      they address more questions with greater clarity and sophistication.
CI  - (c) 2010 Elsevier Inc. All rights reserved.
FAU - Lu, Liang-Jing
AU  - Lu LJ
AD  - Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA 90048,
      USA.
FAU - Wallace, Daniel J
AU  - Wallace DJ
FAU - Navarra, Sandra V
AU  - Navarra SV
FAU - Weisman, Michael H
AU  - Weisman MH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20081107
PL  - United States
TA  - Semin Arthritis Rheum
JT  - Seminars in arthritis and rheumatism
JID - 1306053
SB  - IM
MH  - Clinical Trials as Topic
MH  - Guidelines as Topic
MH  - Humans
MH  - *Lupus Erythematosus, Systemic
MH  - Registries/*standards
RF  - 474
EDAT- 2008/11/11 09:00
MHDA- 2010/04/20 06:00
CRDT- 2008/11/11 09:00
PHST- 2008/07/01 00:00 [received]
PHST- 2008/08/07 00:00 [revised]
PHST- 2008/08/25 00:00 [accepted]
PHST- 2008/11/11 09:00 [pubmed]
PHST- 2010/04/20 06:00 [medline]
PHST- 2008/11/11 09:00 [entrez]
AID - S0049-0172(08)00156-X [pii]
AID - 10.1016/j.semarthrit.2008.08.009 [doi]
PST - ppublish
SO  - Semin Arthritis Rheum. 2010 Feb;39(4):224-45. doi:
      10.1016/j.semarthrit.2008.08.009. Epub 2008 Nov 7.


PMID- 18955359
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121011
LR  - 20200929
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 7
IP  - 3
DP  - 2010 Sep
TI  - Ethical Considerations for Acupuncture and Chinese Herbal Medicine Clinical
      Trials: A Cross-cultural Perspective.
PG  - 295-301
LID - 10.1093/ecam/nen055 [doi]
AB  - MANY ETHICAL CONCERNS REVOLVE AROUND THE FOUR BASIC PRINCIPLES OF RESEARCH: merit
      and integrity, respect for human beings, weighting of risk-benefit and justice.
      These principles form the basis for any discussion concerning human research
      ethics and are applicable to all areas of research including acupuncture and
      Chinese herbal medicine. World Health Organisation document, Guidelines for
      Clinical Research on Acupuncture, states that 'consideration should be given to
      the different value systems that are involved in human rights such as social,
      cultural and historical issues' and that 'further studies should be conducted in 
      relation to ethical issues involved in clinical research on acupuncture'. In
      addition to outlining the four basic principles, this paper will also examine the
      effect of Asian culture on Western human research ethics and how this may impact 
      upon issues such as informed consent and weighting of risk-benefit.
FAU - Zaslawski, Christopher
AU  - Zaslawski C
AD  - College of Traditional Chinese Medicine, Department of Medical and Molecular
      Biosciences, Faculty of Science, University of Technology, Sydney, Australia.
LA  - eng
PT  - Journal Article
DEP - 20080821
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC2887333
EDAT- 2008/10/29 09:00
MHDA- 2008/10/29 09:01
CRDT- 2008/10/29 09:00
PHST- 2007/10/25 00:00 [received]
PHST- 2008/05/27 00:00 [accepted]
PHST- 2008/10/29 09:00 [pubmed]
PHST- 2008/10/29 09:01 [medline]
PHST- 2008/10/29 09:00 [entrez]
AID - nen055 [pii]
AID - 10.1093/ecam/nen055 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2010 Sep;7(3):295-301. doi:
      10.1093/ecam/nen055. Epub 2008 Aug 21.


PMID- 18937057
OWN - NLM
STAT- MEDLINE
DCOM- 20100701
LR  - 20220818
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 16
IP  - 1
DP  - 2010 Mar
TI  - Philosophical aspects of dual use technologies.
PG  - 17-31
LID - 10.1007/s11948-008-9086-1 [doi]
AB  - The term dual use technologies refers to research and technology with the
      potential both to yield valuable scientific knowledge and to be used for
      nefarious purposes with serious consequences for public health or the
      environment. There are two main approaches to assessing dual use technologies:
      pragmatic and metaphysical. A pragmatic approach relies on ethical principles and
      norms to generate specific guidance and policy for dual use technologies. A
      metaphysical approach exhorts us to the deeper study of human nature, our
      intentions, goals, values ideals and social relations when considering dual use
      technology. Use of science and technology (S and T) is determined by two
      components of human nature: human intentions and choices. We have drawn a
      distinction between specific measures, goals and intentions with respect to
      technologies in order to show that moral judgment about technologies must precede
      their use. Understanding of our intentionality and values, and our moral ideals, 
      as a measurable, tangible part of the real world is important for the prevention 
      of any possible harm from S and T. In the context of dual use technologies, we
      stress the importance of three main understandings of human nature:
      vulnerability, responsibility and narrative identity. These can become a strong
      ontological "antidote" to technology's poisoning of modern man. Each new
      technology can be measured and compared with man's values, traditions and
      societal norms. This can be done bearing in mind the concept that human nature is
      not dualistic, but pluralistic. A system of ethical principles that includes the 
      principles of good intentions, the correspondence of goals and means, the
      balancing of risks and benefits, simplicity, and contextuality, will help ensure 
      that technologies are more humanistic and friendly to human beings.
FAU - Pustovit, Svitlana V
AU  - Pustovit SV
AD  - Philosophy Department, National Medical Academy of Postgraduate Education named
      after P. L. Shupyk, Dorogozhits'ka 9, Kiev 04112, Ukraine. kvll@voliacable.com
FAU - Williams, Erin D
AU  - Williams ED
LA  - eng
PT  - Journal Article
DEP - 20081021
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Beneficence
MH  - *Double Effect Principle
MH  - *Ethics, Research
MH  - Goals
MH  - Humanism
MH  - Humans
MH  - Intention
MH  - Knowledge
MH  - Metaphysics
MH  - Morals
MH  - Narration
MH  - *Philosophy, Medical
MH  - Postmodernism
MH  - Principle-Based Ethics
MH  - Risk Assessment
MH  - Science/*ethics/organization & administration
MH  - Self Concept
MH  - Social Responsibility
MH  - Technology Assessment, Biomedical/*ethics/organization & administration
EDAT- 2008/10/22 09:00
MHDA- 2010/07/02 06:00
CRDT- 2008/10/22 09:00
PHST- 2008/05/13 00:00 [received]
PHST- 2008/09/01 00:00 [accepted]
PHST- 2008/10/22 09:00 [pubmed]
PHST- 2010/07/02 06:00 [medline]
PHST- 2008/10/22 09:00 [entrez]
AID - 10.1007/s11948-008-9086-1 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2010 Mar;16(1):17-31. doi: 10.1007/s11948-008-9086-1. Epub 2008
      Oct 21.


PMID- 18801638
OWN - NLM
STAT- MEDLINE
DCOM- 20110204
LR  - 20151119
IS  - 0736-4679 (Print)
IS  - 0736-4679 (Linking)
VI  - 39
IP  - 4
DP  - 2010 Oct
TI  - A brief educational intervention may increase public acceptance of emergency
      research without consent.
PG  - 419-35
LID - 10.1016/j.jemermed.2007.12.033 [doi]
AB  - OBJECTIVES: We hypothesized that knowing the regulations regarding emergency
      research without consent would increase public support for this type of research.
      METHODS: Randomized controlled trial. Consecutive patients presenting during
      eight 24-h periods received one of two interviews; the intervention interview
      included an educational paragraph. RESULTS: There were 473 (74% of eligible)
      patients who participated: 51% (95% confidence interval [CI] 46-55) were willing 
      to be enrolled in a study using exception to informed consent; 84% (95% CI 80-87)
      believed that current therapy for cardiac arrest offers >/= 50% chance of full
      recovery, and these patients were less willing to enroll (odds ratio [OR] 0.5,
      95% CI 0.3-0.9). The educational intervention increased willingness to enroll (OR
      1.3, 95% CI 1.0-1.6, p = 0.03). CONCLUSIONS: A brief educational intervention had
      only a modest effect on willingness to participate in emergency research without 
      consent. It may be more important to educate patients on the shortcomings of
      current therapy than on the ethical and regulatory justifications for such
      research.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Goldstein, Joshua N
AU  - Goldstein JN
AD  - Department of Emergency Medicine, Brigham & Women's Hospital, Boston,
      Massachusetts, USA.
FAU - Delaney, Kate E
AU  - Delaney KE
FAU - Pelletier, Andrea J
AU  - Pelletier AJ
FAU - Fisher, Jonathan
AU  - Fisher J
FAU - Blanc, Phillip G
AU  - Blanc PG
FAU - Halsey, Mark
AU  - Halsey M
FAU - Pallin, Daniel J
AU  - Pallin DJ
FAU - Camargo, Carlos A Jr
AU  - Camargo CA Jr
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20080918
PL  - United States
TA  - J Emerg Med
JT  - The Journal of emergency medicine
JID - 8412174
SB  - IM
MH  - *Biomedical Research
MH  - Boston
MH  - Chi-Square Distribution
MH  - Confidence Intervals
MH  - Demography
MH  - Emergency Service, Hospital
MH  - *Emergency Treatment
MH  - Female
MH  - Humans
MH  - Informed Consent
MH  - Interviews as Topic
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - *Patient Education as Topic
MH  - *Public Opinion
MH  - Surveys and Questionnaires
EDAT- 2008/09/20 09:00
MHDA- 2011/02/05 06:00
CRDT- 2008/09/20 09:00
PHST- 2007/09/25 00:00 [received]
PHST- 2007/12/19 00:00 [revised]
PHST- 2007/12/22 00:00 [accepted]
PHST- 2008/09/20 09:00 [pubmed]
PHST- 2011/02/05 06:00 [medline]
PHST- 2008/09/20 09:00 [entrez]
AID - S0736-4679(08)00241-2 [pii]
AID - 10.1016/j.jemermed.2007.12.033 [doi]
PST - ppublish
SO  - J Emerg Med. 2010 Oct;39(4):419-35. doi: 10.1016/j.jemermed.2007.12.033. Epub
      2008 Sep 18.


PMID- 18665846
OWN - NLM
STAT- MEDLINE
DCOM- 20100614
LR  - 20121115
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 10
IP  - 1
DP  - 2010 Apr
TI  - Ethical problems in conducting research in acute epidemics: the Pfizer meningitis
      study in Nigeria as an illustration.
PG  - 1-10
LID - 10.1111/j.1471-8847.2008.00239.x [doi]
AB  - The ethics of conducting research in epidemic situations have yet to account
      fully for differences in the proportion and acuteness of epidemics, among other
      factors. While epidemics most often arise from infectious diseases, not all
      infectious diseases are of epidemic proportions, and not all epidemics occur
      acutely. These and other variations constrain the generalization of ethical
      decision-making and impose ethical demands on the individual researcher in a way 
      not previously highlighted. This paper discusses a number of such constraints and
      impositions. It applies the ethical principles enunciated by Emmanuel et al.(1)
      to the controversial Pfizer study in Nigeria in order to highlight the particular
      ethical concerns of acute epidemic research, and suggest ways of meeting such
      challenges. The paper recommends that research during epidemics should be partly 
      evaluated on its own merits in order to determine its ethical appropriateness to 
      the specific situation. Snap decisions to conduct research during acute epidemics
      should be resisted. Community engagement, public notification and good
      information management are needed to promote the ethics of conducting research
      during acute epidemics. Individual consent is most at risk of being compromised, 
      and every effort should be made to ensure that it is maintained and valid. Use of
      data safety management boards should be routine. Acute epidemics also present
      opportunities to enhance the social value of research and maximize its benefits
      to communities. Ethical research is possible in acute epidemics, if the potential
      challenges are thought of ahead of time and appropriate precautions taken.
FAU - Ezeome, Emmanuel R
AU  - Ezeome ER
AD  - Department of Surgery, University of Nigeria Teaching Hospital, Enugu, Nigeria.
      ezeome95@gmail.com
FAU - Simon, Christian
AU  - Simon C
LA  - eng
PT  - Journal Article
DEP - 20080728
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Fluoroquinolones)
RN  - 7QVV6I50DT (alatrofloxacin)
SB  - IM
MH  - Acute Disease
MH  - Administration, Oral
MH  - Adult
MH  - Anti-Infective Agents/administration & dosage/*therapeutic use
MH  - Child
MH  - Confidentiality
MH  - *Disease Outbreaks
MH  - Drug Industry/*ethics/legislation & jurisprudence
MH  - Ethics Committees, Research
MH  - Ethics, Research
MH  - Fluoroquinolones/administration & dosage/*therapeutic use
MH  - Humans
MH  - International Cooperation
MH  - Meningitis/*drug therapy/*epidemiology
MH  - Nigeria/epidemiology
MH  - Parental Consent/ethics
MH  - Patient Selection
MH  - Randomized Controlled Trials as Topic/*ethics
MH  - Reproducibility of Results
MH  - Research Design
MH  - Social Values
MH  - Therapeutic Human Experimentation/*ethics
EDAT- 2008/07/31 09:00
MHDA- 2010/06/15 06:00
CRDT- 2008/07/31 09:00
PHST- 2008/07/31 09:00 [pubmed]
PHST- 2010/06/15 06:00 [medline]
PHST- 2008/07/31 09:00 [entrez]
AID - DEWB239 [pii]
AID - 10.1111/j.1471-8847.2008.00239.x [doi]
PST - ppublish
SO  - Dev World Bioeth. 2010 Apr;10(1):1-10. doi: 10.1111/j.1471-8847.2008.00239.x.
      Epub 2008 Jul 28.


PMID- 18644014
OWN - NLM
STAT- MEDLINE
DCOM- 20100420
LR  - 20100106
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 24
IP  - 2
DP  - 2010 Feb
TI  - Patient autonomy, assessment of competence and surrogate decision-making: a call 
      for reasonableness in deciding for others.
PG  - 87-95
LID - 10.1111/j.1467-8519.2008.00672.x [doi]
AB  - In this paper, I address some of the shortcomings of established clinical ethics 
      centring on personal autonomy and consent and what I label the Doctrine of
      Respecting Personal Autonomy in Healthcare. I discuss two implications of this
      doctrine: 1) the practice for treating patients who are considered to have
      borderline decision-making competence and 2) the practice of surrogate
      decision-making in general. I argue that none of these practices are currently
      aligned with respectful treatment of vulnerable individuals. Because of
      'structural arbitrariness' in the whole process of how we assess decision-making 
      competence, this area is open to disrespectful treatment of people. The practice 
      of surrogate decision- making on the basis of a single person's judgment is
      arguably not consistent with ethical and political requirements derived from the 
      doctrine itself. In response to the inadequacies of the doctrine, I suggest a
      framework for reasonableness in surrogate decision-making which might allow
      practice to avoid the problems above. I conclude by suggesting an extended
      concept of Patient Autonomy which integrates both personal autonomy and the
      regulative idea of morality that is required by reasonableness in deciding for
      non-competent others.
FAU - Baeroe, Kristine
AU  - Baeroe K
AD  - Department of Public Health and Primary Health Care, University of Bergen,
      Norway. kristine.baroe@isf.uib.no
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080717
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Decision Making/*ethics
MH  - Humans
MH  - *Mental Competency
MH  - *Personal Autonomy
MH  - Third-Party Consent/*ethics
EDAT- 2008/07/23 09:00
MHDA- 2010/04/21 06:00
CRDT- 2008/07/23 09:00
PHST- 2008/07/23 09:00 [pubmed]
PHST- 2010/04/21 06:00 [medline]
PHST- 2008/07/23 09:00 [entrez]
AID - BIOT672 [pii]
AID - 10.1111/j.1467-8519.2008.00672.x [doi]
PST - ppublish
SO  - Bioethics. 2010 Feb;24(2):87-95. doi: 10.1111/j.1467-8519.2008.00672.x. Epub 2008
      Jul 17.


PMID- 18439786
OWN - NLM
STAT- MEDLINE
DCOM- 20100913
LR  - 20191210
IS  - 0736-4679 (Print)
IS  - 0736-4679 (Linking)
VI  - 38
IP  - 4
DP  - 2010 May
TI  - Infrared ear thermometry in water-related accidents-not a good choice.
PG  - 417-21
LID - 10.1016/j.jemermed.2007.10.061 [doi]
AB  - Hypothermia in near-drowning victims is a serious problem that impacts clinical
      decision-making. The purpose of this trial was to determine the reliability of
      tympanic temperature measurements compared to oral temperature measurements after
      immersion in water. After ethical approval was obtained, we studied oral and
      tympanic temperature in 25 volunteer swimmers (aged 18-49 years). Sublingual
      (Fixotherm; Tradesell Europe, Eglharting, Germany) and tympanic (First Temp
      Genius; Sherwood Medical, Sulzbach, Germany) temperature measurements were
      performed before entering the water, after 45 min of immersion in water, and 15
      min after leaving the water. During the immersion phase, the ears were
      temporarily immersed. A control group (the same 25 volunteers) had to swim for
      the same amount of time without ever immersing their heads in the water. The
      trial was performed in an indoor swimming pool at 28 degrees C water and 30
      degrees C air temperature. The oral temperature did not change over time in
      either group. The tympanic temperature was significantly lower after immersion
      compared to baseline in the "immersed" group (33.7 degrees C vs. 37.5 degrees C, 
      p < 0.001), increased significantly in the recovery period, but remained
      significantly lower than baseline (36.0 degrees C vs. 37.5 degrees C, p < 0.001).
      At baseline, the oral temperature was lower compared to the tympanic temperature.
      This relationship reversed after immersion and remained reversed until the end of
      the trial in the immersion group. The control group maintained oral temperatures 
      lower than tympanic throughout the study; furthermore, the control group had no
      clinically relevant change in oral or tympanic temperature over the time
      (tympanic temperature: 37.4 degrees C vs. 37.2 degrees C, p = 0.06). Our data
      suggest that in water-related accidents such as near drowning, the values of body
      (core) temperature obtained via use of infrared ear thermometry are unreliable,
      and should not be used for clinical decision-making.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Muth, Claus-Martin
AU  - Muth CM
AD  - Sektion Anaesthesiologische Pathophysiologie und Verfahrensentwicklung,
      Universitaetsklinikum Ulm, Germany.
FAU - Shank, Erik
AU  - Shank E
FAU - Hauser, Balazs
AU  - Hauser B
FAU - Radermacher, Peter
AU  - Radermacher P
FAU - Groger, Michael
AU  - Groger M
FAU - Ehrmann, Ulrich
AU  - Ehrmann U
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20080424
PL  - United States
TA  - J Emerg Med
JT  - The Journal of emergency medicine
JID - 8412174
SB  - IM
CIN - J Emerg Med. 2012 Jan;42(1):66-7; author reply 67. PMID: 21982625
MH  - Adult
MH  - Case-Control Studies
MH  - Cold Temperature
MH  - False Positive Reactions
MH  - Female
MH  - Humans
MH  - Hypothermia/*diagnosis
MH  - Male
MH  - Middle Aged
MH  - Near Drowning/diagnosis
MH  - Thermography/*instrumentation
MH  - Young Adult
EDAT- 2008/04/29 09:00
MHDA- 2010/09/14 06:00
CRDT- 2008/04/29 09:00
PHST- 2006/10/08 00:00 [received]
PHST- 2007/06/03 00:00 [revised]
PHST- 2007/10/30 00:00 [accepted]
PHST- 2008/04/29 09:00 [pubmed]
PHST- 2010/09/14 06:00 [medline]
PHST- 2008/04/29 09:00 [entrez]
AID - S0736-4679(08)00014-0 [pii]
AID - 10.1016/j.jemermed.2007.10.061 [doi]
PST - ppublish
SO  - J Emerg Med. 2010 May;38(4):417-21. doi: 10.1016/j.jemermed.2007.10.061. Epub
      2008 Apr 24.


PMID- 18438721
OWN - NLM
STAT- MEDLINE
DCOM- 20100701
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 16
IP  - 1
DP  - 2010 Mar
TI  - Managing dual use technology: it takes two to tango.
PG  - 77-83
LID - 10.1007/s11948-008-9062-9 [doi]
AB  - Like nuclear energy, most technologies could have dual use-for health and well
      being and disaster and terror. Some research publications have brought to the
      forefront the tragic consequences of the latter potential through their possible 
      use. Monitoring life science research and development (R&D) to prevent possible
      misuse is a challenging task globally, more so in developing economies like
      India, which are emerging as major biotech hubs. As a signatory to the Biological
      and Toxin Weapons Convention, India has put in motion a process of evolving a
      series of measures to manage dual-use technology. The Indian Council of Medical
      Research (ICMR) has taken a lead in drafting model codes of conduct, ethics and
      practice for use by other S&T agencies to tailor them as per their requirements. 
      Taking cue from the discussions held by the editors of the various medical and
      science journals in the developed world, the Indian Journal of Medical Research, 
      the official publication of the ICMR, is working on policy and uniform practice
      of publication of dual-use research results. The Government of India too has
      promulgated legal provisions to minimize the risks of misuse of technology, like 
      the Weapons of Mass Destruction Act. Clearly, no single agency would be able to
      manage the dual-use of technology effectively. Multiple agencies have to come
      together to work in tandem for effective implementation of various measure and
      also like Janus, ensure that they are neither too restrictive nor intrusive to
      discourage the development of science.
FAU - Kant, Lalit
AU  - Kant L
AD  - Indian Council of Medical Research, Ansari Nagar, New Delhi 110029, India.
FAU - Mourya, D T
AU  - Mourya DT
LA  - eng
PT  - Journal Article
DEP - 20080426
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Beneficence
MH  - Biomedical Research/*ethics/organization & administration
MH  - *Codes of Ethics
MH  - Developing Countries
MH  - *Double Effect Principle
MH  - Editorial Policies
MH  - Ethics, Medical/education
MH  - *Government Regulation
MH  - Guidelines as Topic
MH  - Humans
MH  - India
MH  - Periodicals as Topic
MH  - Research Support as Topic/ethics/organization & administration
MH  - Risk Assessment
MH  - Societies, Medical/organization & administration
MH  - Terrorism/ethics/legislation & jurisprudence/prevention & control
MH  - Weapons of Mass Destruction/ethics/legislation & jurisprudence
EDAT- 2008/04/29 09:00
MHDA- 2010/07/02 06:00
CRDT- 2008/04/29 09:00
PHST- 2008/01/18 00:00 [received]
PHST- 2008/03/27 00:00 [accepted]
PHST- 2008/04/29 09:00 [pubmed]
PHST- 2010/07/02 06:00 [medline]
PHST- 2008/04/29 09:00 [entrez]
AID - 10.1007/s11948-008-9062-9 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2010 Mar;16(1):77-83. doi: 10.1007/s11948-008-9062-9. Epub 2008
      Apr 26.


PMID- 18427955
OWN - NLM
STAT- MEDLINE
DCOM- 20100701
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 16
IP  - 1
DP  - 2010 Mar
TI  - Liberty to decide on dual use biomedical research: an acknowledged necessity.
PG  - 43-58
LID - 10.1007/s11948-008-9064-7 [doi]
AB  - Humanity entered the twenty-first century with revolutionary achievements in
      biomedical research. At the same time multiple "dual-use" results have been
      published. The battle against infectious diseases is meeting new challenges, with
      newly emerging and re-emerging infections. Both natural disaster epidemics, such 
      as SARS, avian influenza, haemorrhagic fevers, XDR and MDR tuberculosis and many 
      others, and the possibility of intentional mis-use, such as letters containing
      anthrax spores in USA, 2001, have raised awareness of the real threats. Many
      great men, including Goethe, Spinoza, J.B. Shaw, Fr. Engels, J.F. Kennedy and
      others, have recognized that liberty is also a responsibility. That is why the
      liberty to decide now represents an acknowledged necessity: biomedical research
      should be supported, conducted and published with appropriate measures to prevent
      potential "dual use". Biomedical scientists should work according to the ethical 
      principles of their Code of Conduct, an analogue of Hippocrates Oath of doctors; 
      and they should inform government, society and their juniors about the problem.
      National science consulting boards of experts should be created to prepare
      guidelines and control the problem at state level. An international board should 
      develop minimum standards to be applicable by each country. Bio-preparedness is
      considered another key-measure.
FAU - Keuleyan, Emma
AU  - Keuleyan E
AD  - Department of Clinical Microbiology, Medical Institute, Ministry of the Interior,
      Sofia 1606, Bulgaria. emma_keuleyan@yahoo.com
LA  - eng
PT  - Journal Article
DEP - 20080422
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Beneficence
MH  - Biomedical Research/*ethics
MH  - Bioterrorism/ethics/prevention & control
MH  - Codes of Ethics
MH  - Communicable Diseases, Emerging/prevention & control
MH  - Decision Making/*ethics
MH  - Diffusion of Innovation
MH  - Disaster Planning/organization & administration
MH  - Disasters/prevention & control
MH  - *Double Effect Principle
MH  - *Freedom
MH  - Guidelines as Topic
MH  - Humans
MH  - International Cooperation
MH  - *Philosophy, Medical
MH  - Science/*ethics
MH  - Social Responsibility
MH  - World Health Organization/organization & administration
PMC - PMC7089121
EDAT- 2008/04/23 09:00
MHDA- 2010/07/02 06:00
CRDT- 2008/04/23 09:00
PHST- 2007/12/03 00:00 [received]
PHST- 2008/03/27 00:00 [accepted]
PHST- 2008/04/23 09:00 [pubmed]
PHST- 2010/07/02 06:00 [medline]
PHST- 2008/04/23 09:00 [entrez]
AID - 10.1007/s11948-008-9064-7 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2010 Mar;16(1):43-58. doi: 10.1007/s11948-008-9064-7. Epub 2008
      Apr 22.


PMID- 18418725
OWN - NLM
STAT- MEDLINE
DCOM- 20100629
LR  - 20100401
IS  - 1573-1677 (Electronic)
IS  - 1382-4996 (Linking)
VI  - 15
IP  - 2
DP  - 2010 May
TI  - Modeling manipulation in medical education.
PG  - 291-5
LID - 10.1007/s10459-008-9112-8 [doi]
AB  - As residents and medical students progress through their medical training, they
      are presented with multiple instances in which they feel they must manipulate the
      healthcare system and deceive others in order to efficiently treat their
      patients. This, however, creates a culture of manipulation resulting in untoward 
      effects on trainees' ethical and professional development. Yet manipulation need 
      not be a skill necessary to practice medicine, and steps should be taken by both 
      individuals and institutions to combat the view that the way medicine must be
      practiced "in the real world" is somehow different from what one's affective
      moral sense implores.
FAU - Dailey, Jason I
AU  - Dailey JI
AD  - Department of Psychiatry, Tripler Army Medical Center, Honolulu, HI 96859, USA.
      Jason.Dailey@amedd.army.mil
LA  - eng
PT  - Journal Article
DEP - 20080417
PL  - Netherlands
TA  - Adv Health Sci Educ Theory Pract
JT  - Advances in health sciences education : theory and practice
JID - 9612021
SB  - IM
MH  - Ethics, Medical/*education
MH  - Humans
MH  - Internship and Residency/*ethics/*methods
MH  - *Machiavellianism
MH  - Professional Competence
MH  - Students, Medical/*psychology
EDAT- 2008/04/18 09:00
MHDA- 2010/06/30 06:00
CRDT- 2008/04/18 09:00
PHST- 2007/11/16 00:00 [received]
PHST- 2008/03/24 00:00 [accepted]
PHST- 2008/04/18 09:00 [pubmed]
PHST- 2010/06/30 06:00 [medline]
PHST- 2008/04/18 09:00 [entrez]
AID - 10.1007/s10459-008-9112-8 [doi]
PST - ppublish
SO  - Adv Health Sci Educ Theory Pract. 2010 May;15(2):291-5. doi:
      10.1007/s10459-008-9112-8. Epub 2008 Apr 17.


PMID- 28230942
STAT- Publisher
DA  - 20170224
PB  - National Institute for Health and Care Excellence (NICE)
CTI - NICE Citizens Council Reports
DP  - 2011 Nov 4
BTI - How Should NICE Assess Future Costs and Health Benefits?
AB  - The Citizens Council provides NICE with a public perspective on overarching moral
      and ethical issues that NICE should take into account when producing guidance.
      Made up of members of the public, broadly representative of the adult UK
      population, the Council operates through a "citizens' jury" style meeting, to
      explore and respond to a question set by NICE. The Citizens Council met in
      November 2011 to discuss the question: "How should NICE assess future costs and
      health benefits?" This meeting explored the issue of 'discounting', which is the 
      way in which economists calculate and value the costs and health benefits that
      occur in the future. A majority agreed that discounting is a legitimate feature
      of the calculation of future costs and benefits. Most of us accepted the
      relevance to health, in principle, of the three factors used to arrive at the
      discount rate ("catastrophe risk", "economic growth" and "time preference"). But 
      a good many of us had reservations about the suitability of the Treasury's
      standard two per cent figure for economic growth, particularly in the light of
      the current state of global markets. However we also felt that there is a case
      for treating costs and benefits of health differently. With respect to benefits, 
      most of us agreed that there are occasions when NICE should depart from its
      current discounting policy - which is to apply a 3.5 per cent discount rate for
      costs and benefits in line with all public bodies. Although we were reluctant to 
      compile a definitive list of the relevant factors, those that received a mention 
      included interventions where costs were mostly up front but where benefits would 
      be accrued over a long time in the future, those that yielded a very high QALY
      benefit or a total cure, and (rather less unanimously) those that involved the
      treatment of children. We felt that the question of which discount rate to use in
      which circumstances was beyond our competence, but that in practice it would be
      up to the committee to decide as they would know when it is appropriate. We were 
      also aware that there is a health economic argument that suggests that this
      approach would have implications for the threshold range. One issue that
      surprised and puzzled us was the effect of discounting when the costs of an
      intervention are borne in its earliest stages, but the benefits accrue over many 
      years or even decades: the case with most preventive and public health projects. 
      We felt that the benefit of these interventions could be undervalued. We were
      told that, in practice, this is seldom a handicap because most public health
      measures are so cheap and/or cost effective that the negative effects of
      discounting are only a minor influence on the final calculation. However, given
      that the saying "Prevention is better than cure" is a piece of folk wisdom
      acknowledged by public and professionals alike, it seems odd that health
      economists should employ a methodology offering such a paradoxical outcome where 
      treatment is valued over prevention. Should circumstances arise in which a
      particular public health measure is disadvantaged by standard discounting, we
      would recommend that NICE take whatever measures were necessary to achieve a
      common-sense conclusion. Finally, we thought creatively about how discounting
      might be seen by different age groups in society. It seemed that, depending on
      whether the discount rate used could potentially favour a given group rather than
      another, views on the usefulness of discounting were likely to change
      accordingly.
CI  - Copyright (c) 2011 National Institute for Health and Clinical Excellence, unless 
      otherwise stated. All rights reserved.
CN  - NICE Citizens Council
LA  - eng
PT  - Book
PL  - London
OTO - NOTNLM
OT  - citizens council
OT  - citizens jury
OT  - social values
OT  - societal values
OT  - social value judgements
OT  - ethics
OT  - healthcare ethics
OT  - health technology appraisal
OT  - health technology assessment
OT  - health technology evaluation
OT  - discounting
OT  - future costs
OT  - future benefits
OT  - cost effectiveness
EDAT- 2017/02/24 06:01
MHDA- 2017/02/24 06:01
CDAT- 2017/02/24 06:01
AID - NBK401699 [bookaccession]


PMID- 27195356
STAT- Publisher
DA  - 20160520
PB  - Canadian Agency for Drugs and Technologies in Health
CTI - CADTH Optimal Use Reports
DP  - 2011 May
BTI - Optimal Therapy Recommendation for the Use of Solvent/Detergent-Treated Human
      Plasma: Pilot Project
AB  - Canadian jurisdictions (except Quebec) must make a decision on the provision of
      S/D plasma to clinicians and patients. If funding is approved, the Canadian Blood
      Services (CBS) will be responsible for the storage and distribution of this blood
      product in nine provinces and three territories. An initial review of S/D plasma 
      was conducted by CBS in 2009/2010, with additional input through the National
      Advisory Committee on Blood and Blood Products (NAC). In the fall of 2010,
      Canadian jurisdictions, through the Provincial/Territorial Blood Liaison
      Committee (PTBLC), sought further input from CADTH. In response, CADTH initiated 
      a pilot project and convened a Panel of Experts to evaluate the clinical and
      cost-effectiveness of S/D plasma versus standard plasma and to also consider the 
      ethical implications of providing S/D plasma under certain criteria. These
      criteria were established by PTBLC and CBS on the basis that there exist chronic 
      hematological conditions for which treatment involves administering a high volume
      of plasma transfusions. Three specific populations were selected by PTBLC and CBS
      for this pilot project, namely: patients with thrombotic thrombocytopenic purpura
      (TTP); patients with hemolytic uremic syndrome (HUS); patients with clotting
      factor deficiencies for which specific licensed concentrates may not be readily
      available (e.g., factor V, factor XI, factor XIII).
CI  - Copyright (c) 2011 CADTH.
LA  - eng
PT  - Review
PT  - Book
PL  - Ottawa (ON)
EDAT- 2016/05/20 06:00
MHDA- 2016/05/20 06:00
CDAT- 2016/05/20 06:00
AID - NBK362105 [bookaccession]


PMID- 27195353
STAT- Publisher
DA  - 20160520
PB  - Canadian Agency for Drugs and Technologies in Health
CTI - CADTH Optimal Use Reports
DP  - 2011 May
BTI - Ethical Assessment: Open versus Restricted Access and Optimal Use of Solvent/
      Detergent-Treated Human Plasma (Octaplas): Pilot Project
AB  - The purpose of this ethical assessment is to identify and discuss ethical issues 
      related to optimal use recommendations for solvent/detergent-treated human plasma
      (Octaplas) (S/D plasma) - a blood product derivative - in Canada. This assessment
      compliments a set of clinical and cost-effectiveness analyses done for the
      purpose of informing a reasonable funding decision on S/D plasma.
CI  - Copyright (c) 2011 CADTH.
FAU - Kekewich, Michael
AU  - Kekewich M
FAU - Foreman, Thomas
AU  - Foreman T
LA  - eng
PT  - Review
PT  - Book
PL  - Ottawa (ON)
EDAT- 2016/05/20 06:00
MHDA- 2016/05/20 06:00
CDAT- 2016/05/20 06:00
AID - NBK362094 [bookaccession]


PMID- 26269877
STAT- Publisher
DA  - 20150814
ISBN- 9789241502948
ISBN- 9789241502955
PB  - World Health Organization
CTI - WHO Guidelines Approved by the Guidelines Review Committee
DP  - 2011
BTI - Standards and Operational Guidance for Ethics Review of Health-Related Research
      with Human Participants
AB  - The new WHO publication "Standards and operational guidance for ethics review of 
      health-related research with human participants", is a compilation of 10
      standards that are applicable to the ethics review of health related research
      with human participants. This document is intended to provide guidance on the
      research ethics review process, not to take a substantive position on how
      particular ethical dilemmas in health-related research should be resolved. It is 
      designed to serve as a basis upon which Research Ethics Committees (RECs) can
      develop their own specific practices and written procedures, and benchmark their 
      achievements. The term "standards" is used to delineate general principles and
      norms that all research ethics systems are expected to follow. This publication
      highlights the importance of a systems approach to research ethics, and includes 
      and delineates the role of national governments and relevant legal and regulatory
      authorities.
CI  - Copyright (c) World Health Organization 2011.
LA  - eng
PT  - Review
PT  - Practice Guideline
PT  - Book
PL  - Geneva
EDAT- 2015/08/14 06:00
MHDA- 2015/08/14 06:00
CDAT- 2015/08/14 06:00
AID - NBK310666 [bookaccession]


PMID- 25053010
OWN - NLM
STAT- MEDLINE
DCOM- 20150828
LR  - 20211203
IS  - 1743-7202 (Electronic)
IS  - 1743-7199 (Linking)
VI  - 8
IP  - 1
DP  - 2014
TI  - The impact of familism on physical and mental health among Hispanics in the
      United States.
PG  - 95-127
LID - 10.1080/17437199.2011.569936 [doi]
AB  - The rapidly expanding number of Hispanics living in USA has increased the need
      for their inclusion in research on physical and mental health. Current studies
      that have explored health outcomes among Hispanics have often noted an
      'epidemiological paradox', in which there is a discrepancy between their minority
      status and positive health outcomes when compared with other racial/ethnic
      groups. Certain socio-cultural variables, in particular the value placed on
      family, have been largely implicated in these findings. This review will provide 
      a summary of the literature exploring familism within the structure of the
      Hispanic family and its potential impact on health. We will focus on research
      exploring the plausible impact that family and familism values may have on the
      physical health (particularly within the HIV, diabetes, and breast cancer
      literature) and also on health behaviours of Hispanics, as well as its effect on 
      mental health (particularly related to acculturative stress and caregiver
      stress). Throughout the review, we highlight some of the potential mechanisms by 
      which familism may impact on the health status of Hispanics. We conclude the
      review by noting some of the clinical and ethical implications of this research, 
      and by offering suggestions for future work in this area.
FAU - Katiria Perez, Giselle
AU  - Katiria Perez G
AD  - a Department of Psychology , University of Connecticut , 406 Babbidge Road, Unit 
      1020, Storrs , CT 06269 , USA.
FAU - Cruess, Dean
AU  - Cruess D
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110525
PL  - England
TA  - Health Psychol Rev
JT  - Health psychology review
JID - 101299723
SB  - IM
MH  - Family/*ethnology/psychology
MH  - Health Behavior/*ethnology
MH  - Health Status
MH  - Hispanic or Latino/*psychology
MH  - Humans
MH  - *Mental Health
MH  - *Minority Health
MH  - United States
OTO - NOTNLM
OT  - Hispanic
OT  - Latinos
OT  - familism
OT  - family
OT  - mental health
OT  - physical health
EDAT- 2014/07/24 06:00
MHDA- 2015/09/01 06:00
CRDT- 2014/07/24 06:00
PHST- 2014/07/24 06:00 [entrez]
PHST- 2014/07/24 06:00 [pubmed]
PHST- 2015/09/01 06:00 [medline]
AID - 10.1080/17437199.2011.569936 [doi]
PST - ppublish
SO  - Health Psychol Rev. 2014;8(1):95-127. doi: 10.1080/17437199.2011.569936. Epub
      2011 May 25.


PMID- 24336666
OWN - NLM
STAT- MEDLINE
DCOM- 20140604
LR  - 20131216
IS  - 1741-2684 (Electronic)
IS  - 1471-3012 (Linking)
VI  - 12
IP  - 1
DP  - 2013 Jan
TI  - Ethical and effective: approaches to residential care for people with dementia.
PG  - 111-21
LID - 10.1177/1471301211421707 [doi]
AB  - New knowledge underpins calls for change in approaches to the care of people with
      dementia. Person-centred care is considered essential, whereas purpose-built
      facilities and environmental design are reported to enhance safety and to have a 
      positive effect on behaviour. Research findings have highlighted the
      inappropriate use of antipsychotic drugs and there is debate about their value in
      'managing' symptoms. This paper presents the combination of approaches used to
      enable residents of two secure dementia units to live life within their ability
      and without antipsychotic drugs. Essential to the success of the change process
      was staff education, knowledge of the person, a varied leisure activity programme
      and a supportive environment. Evidence of the positive difference these
      strategies made includes statistics that show a decline in falls and behavioural 
      issues, and feedback from family members. In light of the evidence, this article 
      posits that it is ethically wrong to give people with dementia antipsychotic
      medications because their behaviour is deemed to be unacceptable, when there are 
      other viable options.
FAU - O'Sullivan, Grace
AU  - O'Sullivan G
AD  - Auckland University of Technology, New Zealand.
LA  - eng
PT  - Journal Article
DEP - 20111011
PL  - England
TA  - Dementia (London)
JT  - Dementia (London, England)
JID - 101128698
RN  - 0 (Antipsychotic Agents)
SB  - IM
MH  - Activities of Daily Living
MH  - Antipsychotic Agents/therapeutic use
MH  - Dementia/*therapy
MH  - *Health Knowledge, Attitudes, Practice
MH  - Homes for the Aged/ethics
MH  - Humans
MH  - Leisure Activities
MH  - Long-Term Care/ethics/methods
MH  - Patient-Centered Care/*ethics/*methods
MH  - Physical Stimulation/methods
MH  - Professional-Family Relations
MH  - Residential Treatment/*ethics/*methods
MH  - Social Environment
OTO - NOTNLM
OT  - Activities
OT  - antipsychotics
OT  - dementia
OT  - environment
OT  - occupations
OT  - person-centred care
EDAT- 2013/12/18 06:00
MHDA- 2014/06/05 06:00
CRDT- 2013/12/17 06:00
PHST- 2013/12/17 06:00 [entrez]
PHST- 2013/12/18 06:00 [pubmed]
PHST- 2014/06/05 06:00 [medline]
AID - 1471301211421707 [pii]
AID - 10.1177/1471301211421707 [doi]
PST - ppublish
SO  - Dementia (London). 2013 Jan;12(1):111-21. doi: 10.1177/1471301211421707. Epub
      2011 Oct 11.


PMID- 24273624
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1874-5490 (Print)
IS  - 1874-5490 (Linking)
VI  - 6
DP  - 2013
TI  - Hearing Beyond the Normal Enabled by Therapeutic Devices: The Role of the
      Recipient and the Hearing Profession.
PG  - 607-616
AB  - The time is near where 'therapeutic' bodily assistive devices, developed to mimic
      species-typical body structures in order to enable normative body functioning,
      will allow the wearer to outperform the species-typical body in various
      functions. Although such devices are developed for people that are seen to
      exhibit sub species-typical abilities, many 'therapeutic enhancements' might also
      be desired and used by people that exhibit species-typical body abilities. This
      paper presents the views of members of the World Federation of the Deaf on
      potential beyond species-typical abilities enabling therapeutic assistive devices
      (i.e. related to hearing). Survey respondents showed support for the development 
      and uptake of beyond normal hearing enabling devices. The views of survey
      respondents as clients affect hearing-enabling professions (such as audiologist
      and speech pathologists). The paper analyzes what guidance code of ethics of
      hearing enabling professions give in regards to beyond normal hearing enabling
      devices. This paper suggests that people labeled impaired and the professions
      that serve them should more involved in the enhancement discourse.
FAU - Wolbring, Gregor
AU  - Wolbring G
AD  - Faculty of Medicine, Department of Community Health Science, Program in Community
      Rehabilitation and Disability Studies, University of Calgary, 3330 Hospital Drive
      NW, T2N4N1 Calgary, Alberta Canada.
LA  - eng
PT  - Journal Article
DEP - 20110601
PL  - Netherlands
TA  - Neuroethics
JT  - Neuroethics
JID - 101468977
PMC - PMC3825540
OTO - NOTNLM
OT  - Code of ethics
OT  - Deaf
OT  - Deaf culture
OT  - Hard of hearing
OT  - Hearing profession
OT  - Therapeutic enhancement
EDAT- 2013/11/26 06:00
MHDA- 2013/11/26 06:01
CRDT- 2013/11/26 06:00
PHST- 2011/01/05 00:00 [received]
PHST- 2011/05/25 00:00 [accepted]
PHST- 2013/11/26 06:00 [entrez]
PHST- 2013/11/26 06:00 [pubmed]
PHST- 2013/11/26 06:01 [medline]
AID - 10.1007/s12152-011-9120-x [doi]
AID - 9120 [pii]
PST - ppublish
SO  - Neuroethics. 2013;6:607-616. doi: 10.1007/s12152-011-9120-x. Epub 2011 Jun 1.


PMID- 24273623
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1874-5490 (Print)
IS  - 1874-5490 (Linking)
VI  - 6
DP  - 2013
TI  - The Asilomar Survey: Stakeholders' Opinions on Ethical Issues Related to
      Brain-Computer Interfacing.
PG  - 541-578
AB  - Brain-Computer Interface (BCI) research and (future) applications raise important
      ethical issues that need to be addressed to promote societal acceptance and
      adequate policies. Here we report on a survey we conducted among 145 BCI
      researchers at the 4(th) International BCI conference, which took place in
      May-June 2010 in Asilomar, California. We assessed respondents' opinions about a 
      number of topics. First, we investigated preferences for terminology and
      definitions relating to BCIs. Second, we assessed respondents' expectations on
      the marketability of different BCI applications (BCIs for healthy people, BCIs
      for assistive technology, BCIs-controlled neuroprostheses and BCIs as therapy
      tools). Third, we investigated opinions about ethical issues related to BCI
      research for the development of assistive technology: informed consent process
      with locked-in patients, risk-benefit analyses, team responsibility, consequences
      of BCI on patients' and families' lives, liability and personal identity and
      interaction with the media. Finally, we asked respondents which issues are urgent
      in BCI research.
FAU - Nijboer, Femke
AU  - Nijboer F
AD  - Human Media Interaction, University of Twente, Enschede, the Netherlands.
FAU - Clausen, Jens
AU  - Clausen J
FAU - Allison, Brendan Z
AU  - Allison BZ
FAU - Haselager, Pim
AU  - Haselager P
LA  - eng
PT  - Journal Article
DEP - 20110817
PL  - Netherlands
TA  - Neuroethics
JT  - Neuroethics
JID - 101468977
PMC - PMC3825606
OTO - NOTNLM
OT  - Brain-computer interfaces
OT  - Brain-machine interfaces
OT  - Locked-in syndrome
OT  - Neuroethics
OT  - Neuroimaging
EDAT- 2013/11/26 06:00
MHDA- 2013/11/26 06:01
CRDT- 2013/11/26 06:00
PHST- 2010/12/28 00:00 [received]
PHST- 2011/07/28 00:00 [accepted]
PHST- 2013/11/26 06:00 [entrez]
PHST- 2013/11/26 06:00 [pubmed]
PHST- 2013/11/26 06:01 [medline]
AID - 10.1007/s12152-011-9132-6 [doi]
AID - 9132 [pii]
PST - ppublish
SO  - Neuroethics. 2013;6:541-578. doi: 10.1007/s12152-011-9132-6. Epub 2011 Aug 17.


PMID- 24273620
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1874-5490 (Print)
IS  - 1874-5490 (Linking)
VI  - 6
DP  - 2013
TI  - Deep Brain Stimulation and the Search for Identity.
PG  - 499-511
AB  - Ethical evaluation of deep brain stimulation as a treatment for Parkinson's
      disease is complicated by results that can be described as involving changes in
      the patient's identity. The risk of becoming another person following surgery is 
      alarming for patients, caregivers and clinicians alike. It is one of the most
      urgent conceptual and ethical problems facing deep brain stimulation in
      Parkinson's disease at this time. In our paper we take issue with this problem on
      two accounts. First, we elucidate what is meant by "becoming another person" from
      a conceptual point of view. After critically discussing two broad approaches we
      concentrate on the notion of "individual identity" which centers on the idea of
      "core attitudes". Subsequently we discuss several approaches to determine what
      distinguishes core attitudes from those that are more peripheral. We argue for a 
      "foundational-function model" highlighting the importance of specific dependency 
      relations between these attitudes. Our second aim is to comment on the
      possibility to empirically measure changes in individual identity and argue that 
      many of the instruments now commonly used in selecting and monitoring
      DBS-patients are inappropriate for this purpose. Future research in this area is 
      advised combining a conceptual and an empirical approach as a basis of sound
      ethical appraisal.
FAU - Witt, Karsten
AU  - Witt K
AD  - Institute for the History of Medicine and Medical Ethics, Research Unit Ethics,
      University of Cologne, Herderstrasse 54, 50931 Cologne, Germany.
FAU - Kuhn, Jens
AU  - Kuhn J
FAU - Timmermann, Lars
AU  - Timmermann L
FAU - Zurowski, Mateusz
AU  - Zurowski M
FAU - Woopen, Christiane
AU  - Woopen C
LA  - eng
PT  - Journal Article
DEP - 20110216
PL  - Netherlands
TA  - Neuroethics
JT  - Neuroethics
JID - 101468977
PMC - PMC3825601
OTO - NOTNLM
OT  - Deep brain stimulation
OT  - Neuroethics
OT  - Parkinson's disease
OT  - Personal identity
OT  - Personality measurement
EDAT- 2013/11/26 06:00
MHDA- 2013/11/26 06:01
CRDT- 2013/11/26 06:00
PHST- 2010/05/05 00:00 [received]
PHST- 2011/01/25 00:00 [accepted]
PHST- 2013/11/26 06:00 [entrez]
PHST- 2013/11/26 06:00 [pubmed]
PHST- 2013/11/26 06:01 [medline]
AID - 10.1007/s12152-011-9100-1 [doi]
AID - 9100 [pii]
PST - ppublish
SO  - Neuroethics. 2013;6:499-511. doi: 10.1007/s12152-011-9100-1. Epub 2011 Feb 16.


PMID- 24273619
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1874-5490 (Print)
IS  - 1874-5490 (Linking)
VI  - 6
DP  - 2013
TI  - Me, Myself and My Brain Implant: Deep Brain Stimulation Raises Questions of
      Personal Authenticity and Alienation.
PG  - 483-497
AB  - In this article, I explore select case studies of Parkinson patients treated with
      deep brain stimulation (DBS) in light of the notions of alienation and
      authenticity. While the literature on DBS has so far neglected the issues of
      authenticity and alienation, I argue that interpreting these cases in terms of
      these concepts raises new issues for not only the philosophical discussion of
      neuro-ethics of DBS, but also for the psychological and medical approach to
      patients under DBS. In particular, I suggest that the experience of alienation
      and authenticity varies from patient to patient with DBS. For some, alienation
      can be brought about by neurointerventions because patients no longer feel like
      themselves. But, on the other hand, it seems alienation can also be cured by DBS 
      as other patients experience their state of mind as authentic under treatment and
      retrospectively regard their former lives without stimulation as alienated. I
      argue that we must do further research on the relevance of authenticity and
      alienation to patients treated with DBS in order to gain a deeper philosophical
      understanding, and to develop the best evaluative criterion for the behavior of
      DBS patients.
FAU - Kraemer, Felicitas
AU  - Kraemer F
AD  - Philosophy & Ethics, Eindhoven University of Technology, IPO 1.01, PO Box 513,
      5600 MB Eindhoven, The Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20110512
PL  - Netherlands
TA  - Neuroethics
JT  - Neuroethics
JID - 101468977
CIN - AJOB Neurosci. 2018;9(4):223-225. PMID: 31011471
PMC - PMC3825521
OTO - NOTNLM
OT  - Alienation
OT  - Authenticity
OT  - Autonomy
OT  - Brain pacemaker
OT  - Deep brain stimulation
OT  - Implant ethics
EDAT- 2013/11/26 06:00
MHDA- 2013/11/26 06:01
CRDT- 2013/11/26 06:00
PHST- 2010/12/04 00:00 [received]
PHST- 2011/04/20 00:00 [accepted]
PHST- 2013/11/26 06:00 [entrez]
PHST- 2013/11/26 06:00 [pubmed]
PHST- 2013/11/26 06:01 [medline]
AID - 10.1007/s12152-011-9115-7 [doi]
AID - 9115 [pii]
PST - ppublish
SO  - Neuroethics. 2013;6:483-497. doi: 10.1007/s12152-011-9115-7. Epub 2011 May 12.


PMID- 23832883
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140607
LR  - 20130708
IS  - 0963-6625 (Print)
IS  - 0963-6625 (Linking)
VI  - 22
IP  - 1
DP  - 2013 Jan
TI  - Post-ecological discourse in the making.
PG  - 33-48
LID - 10.1177/0963662510394949 [doi]
AB  - This article analyses the discourse of 15- to16-year-old Swiss junior high school
      students in order to understand public discourse on the environment and
      environmental protection. Discourse analysis reveals four interpretive
      repertoires as the building blocks for the so-called post-ecological discourse,
      which can be used to describe important aspects of current ways of talking about 
      ecological issues in Europe. We show that 10 theoretically identifiable
      dimensions of this discourse can be understood in terms of a mutual interplay
      between the four interpretive repertoires. Post-ecological discourse in today's
      (Swiss) society appears to be at its core a loss-of-control-discourse, which
      leads (in our students) to a latent eco-depression. Thus, the public
      understanding of science can be affected by unintended consequences of the talk
      itself (in this case an unintended environmental depression), that is, by the
      inherent characteristics of the involved repertoires, here especially the
      so-called folk science repertoire. Fostering public understanding of science is
      thus not merely a question of providing the public with scientific 'facts'. It is
      also an issue of paying attention to the available discursive repertoires. If
      necessary, viable alternative repertoires may have to be offered. In school, for 
      example, conversations about the nature of science, and about complexity and
      applied ethics might help students learn new interpretive repertoires and how to 
      mobilize these in talking about the environment and environmental protection.
FAU - Zeyer, Albert
AU  - Zeyer A
AD  - University of Zurich, Switzerland.
FAU - Roth, Wolff-Michael
AU  - Roth WM
LA  - eng
PT  - Journal Article
DEP - 20110223
PL  - England
TA  - Public Underst Sci
JT  - Public understanding of science (Bristol, England)
JID - 9306503
OTO - NOTNLM
OT  - discourse analysis
OT  - ecology
OT  - environmental education
OT  - interpretive repertoires
OT  - post-ecologism
OT  - science education
EDAT- 2013/07/09 06:00
MHDA- 2013/07/09 06:01
CRDT- 2013/07/09 06:00
PHST- 2013/07/09 06:00 [entrez]
PHST- 2013/07/09 06:00 [pubmed]
PHST- 2013/07/09 06:01 [medline]
AID - 0963662510394949 [pii]
AID - 10.1177/0963662510394949 [doi]
PST - ppublish
SO  - Public Underst Sci. 2013 Jan;22(1):33-48. doi: 10.1177/0963662510394949. Epub
      2011 Feb 23.


PMID- 23526139
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1874-5490 (Print)
IS  - 1874-5490 (Linking)
VI  - 6
IP  - 1
DP  - 2013 Apr
TI  - Introduction: Reconsidering Disorders of Consciousness in Light of
      Neuroscientific Evidence.
PG  - 1-3
AB  - Disorders of consciousness pose a substantial ethical challenge to clinical
      decision making, especially regarding the use of life-sustaining medical
      treatment. For these decisions it is paramount to know whether the patient is
      aware or not. Recent brain research has been striving to assess awareness by
      using mainly functional magnetic resonance imaging. We review the neuroscientific
      evidence and summarize the potential and problems of the different approaches to 
      prove awareness. Finally, we formulate the crucial ethical questions and outline 
      the different articles in this special issue on disorders of consciousness.
FAU - Jox, Ralf J
AU  - Jox RJ
AD  - Institute for Ethics, History and Theory of Medicine, University of Munich,
      Lessingstrasse 2, D-80336 Munchen, Germany.
FAU - Kuehlmeyer, Katja
AU  - Kuehlmeyer K
LA  - eng
PT  - Journal Article
DEP - 20110923
PL  - Netherlands
TA  - Neuroethics
JT  - Neuroethics
JID - 101468977
PMC - PMC3602640
OTO - NOTNLM
OT  - Disorders of consciousness
OT  - End-of-life decisions
OT  - Functional magnetic resonance imaging
OT  - Minimally conscious state
OT  - Vegetative state
EDAT- 2013/03/26 06:00
MHDA- 2013/03/26 06:01
CRDT- 2013/03/26 06:00
PHST- 2011/08/22 00:00 [received]
PHST- 2011/09/07 00:00 [accepted]
PHST- 2013/03/26 06:00 [entrez]
PHST- 2013/03/26 06:00 [pubmed]
PHST- 2013/03/26 06:01 [medline]
AID - 10.1007/s12152-011-9138-0 [doi]
AID - 9138 [pii]
PST - ppublish
SO  - Neuroethics. 2013 Apr;6(1):1-3. doi: 10.1007/s12152-011-9138-0. Epub 2011 Sep 23.


PMID- 23526075
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1874-5490 (Print)
IS  - 1874-5490 (Linking)
VI  - 6
IP  - 1
DP  - 2013 Apr
TI  - Knowledge of Partial Awareness in Disorders of Consciousness: Implications for
      Ethical Evaluations?
PG  - 13-23
AB  - Recent results from neuroimaging appear to indicate that some patients in a
      vegetative state have partially intact awareness. These results may demonstrate
      misdiagnosis and suggest the need not only for alternative forms of treatment,
      but also for the reconsideration of end-of-life decisions in cases of disorders
      of consciousness. This article addresses the second consequence. First, I will
      discuss which aspects of consciousness may be involved in neuroimaging findings. 
      I will then consider various factors relevant to ethical end-of-life
      decision-making, and analyse whether and to what extent the above consequence
      applies to these factors. It will be shown that knowledge of the existence of
      partial awareness in patients with disorders of consciousness only influences
      end-of-life decision-making if certain background assumptions are made.
FAU - Friedrich, Orsolya
AU  - Friedrich O
AD  - Institute of Ethics, History and Theory of Medicine, LMU Munich, Lessingstr. 2,
      80336 Munich, Germany ; Institute of Neuroscience and Medicine, Ethics in the
      Neurosciences (INM-8), Julich Forschungszentrum, Julich, Germany.
LA  - eng
PT  - Journal Article
DEP - 20111209
PL  - Netherlands
TA  - Neuroethics
JT  - Neuroethics
JID - 101468977
PMC - PMC3602638
OTO - NOTNLM
OT  - Awareness
OT  - Disorders of consciousness
OT  - End-of-life decisions
OT  - Neuroimaging
EDAT- 2013/03/26 06:00
MHDA- 2013/03/26 06:01
CRDT- 2013/03/26 06:00
PHST- 2011/08/08 00:00 [received]
PHST- 2011/11/21 00:00 [accepted]
PHST- 2013/03/26 06:00 [entrez]
PHST- 2013/03/26 06:00 [pubmed]
PHST- 2013/03/26 06:01 [medline]
AID - 10.1007/s12152-011-9145-1 [doi]
AID - 9145 [pii]
PST - ppublish
SO  - Neuroethics. 2013 Apr;6(1):13-23. doi: 10.1007/s12152-011-9145-1. Epub 2011 Dec
      9.


PMID- 23476081
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 0038-4941 (Print)
IS  - 0038-4941 (Linking)
VI  - 92
IP  - 5
DP  - 2012 Dec 1
TI  - Framing Nicotine Addiction as a "Disease of the Brain": Social and Ethical
      Consequences.
PG  - 1363-1388
AB  - OBJECTIVES: In this article, we seek to better understand how a genomic vision of
      addiction may influence drug prevention and treatment. Though social influences
      on substance use and abuse (e.g., peer and family influence, socioeconomic
      status) are well documented, biomedical intervention is becoming increasingly
      technoscientific in nature. We wish to elucidate how emphasizing biological
      influences on substance use may lead to a vision of addiction as a phenomenon
      isolated within our bodies and neurochemistry, not lived daily within a complex
      social web of relationships and a particular political economy, including the
      tobacco industry, which aggressively markets products known to cause harm.
      METHODS: We explore the emerging view of addiction as a "disease of the brain" in
      open-ended interviews with 86 stakeholders from the fields of nicotine research
      and tobacco control. Interview data were analyzed using standard qualitative
      techniques. RESULTS: Most stakeholders hold a medicalized view of addiction.
      Though environmental variables are understood to be a primary cause of smoking
      initiation, the speed and strength with which addiction occurs is understood to
      be a largely biological process. Though stakeholders believe that an increased
      focus on addiction as a disease of the brain is not likely to lead to widespread 
      unrealistic expectations for cessation therapies, they remain concerned that it
      may reinforce teenagers' expectations that quitting is not difficult. Finally,
      stakeholder responses indicate that genetic and neuroscientific research is
      unlikely to increase or decrease stigmatization, but will be used by interest
      groups to buttress their existing views of the stigma associated with smoking.
      CONCLUSION: We argue that the main potential harms of focusing on biological
      etiology stem from a concept of addiction that is disassociated from social
      context. Focusing on genetic testing and brain scans may lead one to
      overemphasize pharmaceutical "magic bullet cures" and underemphasize, and
      underfund, more traditional therapies and public health prevention strategies
      that have proven to be effective. Genetic research on addiction may fundamentally
      change our conception of deviance and our identities, and may thus transform our 
      susceptibility to substance use into something isolated in our biology, not
      embedded in a biosocial context.
FAU - Dingel, Molly J
AU  - Dingel MJ
AD  - University of Minnesota Rochester.
FAU - Karkazis, Katrina
AU  - Karkazis K
FAU - Koenig, Barbara A
AU  - Koenig BA
LA  - eng
GR  - R01 DA014577/DA/NIDA NIH HHS/United States
PT  - Journal Article
DEP - 20111018
PL  - United States
TA  - Soc Sci Q
JT  - Social science quarterly
JID - 9882225
PMC - PMC3589175
MID - NIHMS417000
EDAT- 2013/03/12 06:00
MHDA- 2013/03/12 06:01
CRDT- 2013/03/12 06:00
PHST- 2013/03/12 06:00 [entrez]
PHST- 2013/03/12 06:00 [pubmed]
PHST- 2013/03/12 06:01 [medline]
AID - 10.1111/j.1540-6237.2011.00822.x [doi]
PST - ppublish
SO  - Soc Sci Q. 2012 Dec 1;92(5):1363-1388. doi: 10.1111/j.1540-6237.2011.00822.x.
      Epub 2011 Oct 18.


PMID- 23450162
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130304
LR  - 20211021
IS  - 1558-9447 (Print)
IS  - 1558-9447 (Linking)
VI  - 7
IP  - 1
DP  - 2012 Mar
TI  - Cold intolerance after brachial plexus nerve injury.
PG  - 66-71
LID - 10.1007/s11552-011-9370-4 [doi]
AB  - BACKGROUND: The purpose of this study was to evaluate cold intolerance symptoms
      in patients with brachial plexus nerve injury. We hypothesized that higher levels
      of cold intolerance would be associated with more pain, greater disability, and
      unemployment. METHODS: Following research ethics board approval and patient
      consent, we included English-speaking adults more than 6 months following
      brachial plexus nerve injury. Patient questionnaires included Cold Intolerance
      Severity Scale (CISS), McGill Pain Questionnaire, SF-36, DASH, pain
      catastrophizing scale, and Post-traumatic Stress Disorder Checklist. Statistical 
      analyses evaluated the relationships among the questionnaires and the independent
      variables. Multivariable linear regression evaluated the factors associated with 
      the CISS. RESULTS: There were 61 patients, 20 women and 41 men (mean age 40 +/-
      17 years). The mean questionnaire scores indicated high scores in the CISS, DASH,
      and pain intensity. The CISS was significantly higher in women. The final
      regression model with CISS as the dependent variable included the following
      independent variables: McGill pain rating index, DASH score, and time since
      injury. Neither pain catastrophizing nor post-traumatic stress scores were
      retained in the final model. CONCLUSIONS: Patients with brachial plexus nerve
      injury reported substantial cold intolerance which was associated with the McGill
      pain rating index, upper extremity disability, and time since injury.
FAU - Novak, Christine B
AU  - Novak CB
AD  - Hand Program, Toronto Western Hospital, Division of Plastic & Reconstructive
      Surgery, University of Toronto, 399 Bathurst St., EW 2-422, Toronto, ON M5T 2S8
      Canada.
FAU - Anastakis, Dimitri J
AU  - Anastakis DJ
FAU - Beaton, Dorcas E
AU  - Beaton DE
FAU - Mackinnon, Susan E
AU  - Mackinnon SE
FAU - Katz, Joel
AU  - Katz J
LA  - eng
PT  - Journal Article
DEP - 20111112
PL  - United States
TA  - Hand (N Y)
JT  - Hand (New York, N.Y.)
JID - 101264149
PMC - PMC3280360
OTO - NOTNLM
OT  - Brachial plexus
OT  - Cold intolerance
OT  - Nerve injury
OT  - Pain
EDAT- 2013/03/02 06:00
MHDA- 2013/03/02 06:01
CRDT- 2013/03/02 06:00
PHST- 2013/03/02 06:00 [entrez]
PHST- 2013/03/02 06:00 [pubmed]
PHST- 2013/03/02 06:01 [medline]
AID - 10.1007/s11552-011-9370-4 [doi]
AID - 9370 [pii]
PST - ppublish
SO  - Hand (N Y). 2012 Mar;7(1):66-71. doi: 10.1007/s11552-011-9370-4. Epub 2011 Nov
      12.


PMID- 25474217
OWN - NLM
STAT- MEDLINE
DCOM- 20150811
LR  - 20211203
IS  - 1552-4523 (Electronic)
IS  - 0733-4648 (Linking)
VI  - 32
IP  - 2
DP  - 2013 Mar
TI  - Intervention research with minority older adults: challenges encountered,
      solutions enacted, and implications for future work.
PG  - 207-25
LID - 10.1177/0733464811416812 [doi]
AB  - Minority older adults are the fastest-growing segment of the older adult
      population, and a disproportionate number have the greatest psychosocial needs.
      It is the need to understand and bridge existing racial and ethnic disparities
      that makes research with minority older adults so necessary. However, these very 
      vulnerabilities may lead to ethical dilemmas in undertaking research with this
      population, particularly because for many minority older adults, interventions
      offered through research may be the only treatment option available. This article
      discusses this and other ethical issues that may arise in the development and
      implementation of research protocols with minority older adults. By presenting
      specific examples of research challenges encountered the authors aim to encourage
      discussion about the clinically and ethically responsible ways of anticipating,
      preparing for, and addressing ethical research with minority older adults in ways
      that foster research integrity, best serve study participants, and contribute to 
      greater knowledge and understanding for bridging disparities.
FAU - Gelman, Caroline
AU  - Gelman C
AD  - Hunter College of the City University of New York, USA. cgelman@hunter.cuny.edu
FAU - Faul, Anna C
AU  - Faul AC
FAU - Yankeelov, Pamela A
AU  - Yankeelov PA
LA  - eng
GR  - D37HP02904/PHS HHS/United States
GR  - P30-AG08051/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20110815
PL  - United States
TA  - J Appl Gerontol
JT  - Journal of applied gerontology : the official journal of the Southern
      Gerontological Society
JID - 8606502
SB  - IM
MH  - *Blacks
MH  - Community-Based Participatory Research/*ethics
MH  - *Hispanic or Latino
MH  - Humans
MH  - *Minority Groups
MH  - Minority Health
MH  - Patient Selection
MH  - Personal Autonomy
MH  - Research Subjects
MH  - United States
OTO - NOTNLM
OT  - African Americans
OT  - Latinos
OT  - clinical research
OT  - ethical dilemmas
EDAT- 2013/03/01 00:00
MHDA- 2015/08/12 06:00
CRDT- 2014/12/05 06:00
PHST- 2014/12/05 06:00 [entrez]
PHST- 2013/03/01 00:00 [pubmed]
PHST- 2015/08/12 06:00 [medline]
AID - 0733464811416812 [pii]
AID - 10.1177/0733464811416812 [doi]
PST - ppublish
SO  - J Appl Gerontol. 2013 Mar;32(2):207-25. doi: 10.1177/0733464811416812. Epub 2011 
      Aug 15.


PMID- 23329864
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 0303-8300 (Print)
IS  - 0303-8300 (Linking)
VI  - 110
IP  - 3
DP  - 2013 Feb
TI  - Popular Criteria for the Welfare Deservingness of Disability Pensioners: The
      Influence of Structural and Cultural Factors.
PG  - 1103-1117
AB  - Research has shown that several criteria underlie people's opinions about the
      welfare deservingness of benefit recipients. However, it remains unknown which
      factors are associated with the emphasis that people place on such criteria.
      Using a 2006 Dutch national survey on the welfare deservingness of disability
      pension recipients, we study the influence of structural and cultural factors on 
      people's emphasis on three deservingness criteria: control, need, and
      reciprocity. OLS regression analyses show that people's emphasis on specific
      deservingness criteria is strengthened by structural factors that indicate the
      possibility of resource competition such as the following: age, lower levels of
      education, unemployment, and lower income. However, actual personal experience
      with receiving welfare benefits weakens criteria emphasis. Cultural factors such 
      as the espousal of views from the political right and the possession of a strong 
      work ethic are associated with a heightened emphasis on deservingness criteria.
FAU - Jeene, Marjolein
AU  - Jeene M
AD  - Department of Sociology, Tilburg University, P.O. Box 90153, 5000 LE Tilburg, The
      Netherlands.
FAU - van Oorschot, Wim
AU  - van Oorschot W
FAU - Uunk, Wilfred
AU  - Uunk W
LA  - eng
PT  - Journal Article
DEP - 20111204
PL  - United States
TA  - Soc Indic Res
JT  - Social indicators research
JID - 7501244
PMC - PMC3545196
EDAT- 2013/01/19 06:00
MHDA- 2013/01/19 06:01
CRDT- 2013/01/19 06:00
PHST- 2011/11/27 00:00 [accepted]
PHST- 2013/01/19 06:00 [entrez]
PHST- 2013/01/19 06:00 [pubmed]
PHST- 2013/01/19 06:01 [medline]
AID - 10.1007/s11205-011-9974-7 [doi]
AID - 9974 [pii]
PST - ppublish
SO  - Soc Indic Res. 2013 Feb;110(3):1103-1117. doi: 10.1007/s11205-011-9974-7. Epub
      2011 Dec 4.


PMID- 23316090
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 0031-8116 (Print)
IS  - 0031-8116 (Linking)
VI  - 162
IP  - 2
DP  - 2013 Jan
TI  - The armchair and the trolley: an argument for experimental ethics.
PG  - 421-445
AB  - Ethical theory often starts with our intuitions about particular cases and tries 
      to uncover the principles that are implicit in them; work on the 'trolley
      problem' is a paradigmatic example of this approach. But ethicists are no longer 
      the only ones chasing trolleys. In recent years, psychologists and
      neuroscientists have also turned to study our moral intuitions and what underlies
      them. The relation between these two inquiries, which investigate similar
      examples and intuitions, and sometimes produce parallel results, is puzzling.
      Does it matter to ethics whether its armchair conclusions match the
      psychologists' findings? I argue that reflection on this question exposes
      psychological presuppositions implicit in armchair ethical theorising. When these
      presuppositions are made explicit, it becomes clear that empirical evidence can
      (and should) play a positive role in ethical theorising. Unlike recent assaults
      on the armchair, the argument I develop is not driven by a naturalist agenda, or 
      meant to cast doubt on the reliability of our moral intuitions; on the contrary, 
      it is even compatible with non-naturalism, and takes the reliability of intuition
      as its premise. The argument is rather that if our moral intuitions are reliable,
      then psychological evidence should play a surprisingly significant role in the
      justification of moral principles.
FAU - Kahane, Guy
AU  - Kahane G
AD  - Oxford Uehiro Centre for Practical Ethics, Littlegate House, St Ebbe's St,
      Oxford, OX1 1PT UK.
LA  - eng
GR  - Wellcome Trust/United Kingdom
GR  - 086041/Wellcome Trust/United Kingdom
GR  - 087208/Wellcome Trust/United Kingdom
PT  - Journal Article
DEP - 20110811
PL  - Netherlands
TA  - Philos Stud
JT  - Philosophical studies
JID - 100972575
PMC - PMC3540347
EDAT- 2013/01/15 06:00
MHDA- 2013/01/15 06:01
CRDT- 2013/01/15 06:00
PHST- 2013/01/15 06:00 [entrez]
PHST- 2013/01/15 06:00 [pubmed]
PHST- 2013/01/15 06:01 [medline]
AID - 10.1007/s11098-011-9775-5 [doi]
AID - 9775 [pii]
PST - ppublish
SO  - Philos Stud. 2013 Jan;162(2):421-445. doi: 10.1007/s11098-011-9775-5. Epub 2011
      Aug 11.


PMID- 23252025
OWN - NLM
STAT- MEDLINE
DCOM- 20130115
LR  - 20211021
IS  - 0004-1858 (Print)
IS  - 0004-1858 (Linking)
VI  - 108
IP  - 6
DP  - 2011 Nov
TI  - Ethical, legal and policy issues in management of fetal alcohol spectrum
      disorder.
PG  - 123-4
AB  - Alcohol use during pregnancy may have severe and lasting effects on the
      developing fetus. Unfortunately it is often difficult to detect and address
      maternal drinking, as previous articles in this series have demonstrated. The
      difficulty is only compounded by a number of ethical quandaries and legal
      concerns. Underlying most of these concerns is a particularly agonizing conflict 
      of obligations: to protect vulnerable, nascent human life on the one hand, and to
      preserve the privacy, dignity, and trust of one's patient on the other.
FAU - Hackler, Chris
AU  - Hackler C
LA  - eng
GR  - UL1 RR029884/RR/NCRR NIH HHS/United States
GR  - 1UL1RR029884/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Ark Med Soc
JT  - The Journal of the Arkansas Medical Society
JID - 7503069
SB  - IM
MH  - Arkansas
MH  - Female
MH  - Fetal Alcohol Spectrum Disorders/*therapy
MH  - Humans
MH  - Infant, Newborn
MH  - Neonatal Screening/*ethics/*legislation & jurisprudence
MH  - Pregnancy
MH  - Prenatal Care/ethics/legislation & jurisprudence
MH  - Substance Abuse Detection/*ethics/*legislation & jurisprudence
PMC - PMC4049518
MID - NIHMS576485
EDAT- 2012/12/21 06:00
MHDA- 2013/01/16 06:00
CRDT- 2012/12/21 06:00
PHST- 2012/12/21 06:00 [entrez]
PHST- 2012/12/21 06:00 [pubmed]
PHST- 2013/01/16 06:00 [medline]
PST - ppublish
SO  - J Ark Med Soc. 2011 Nov;108(6):123-4.


PMID- 23208837
OWN - NLM
STAT- MEDLINE
DCOM- 20130403
LR  - 20220316
IS  - 1099-1611 (Electronic)
IS  - 1057-9249 (Linking)
VI  - 21
IP  - 12
DP  - 2012 Dec
TI  - Communication about standard treatment options and clinical trials: can we teach 
      doctors new skills to improve patient outcomes?
PG  - 1265-74
LID - 10.1002/pon.2044 [doi]
AB  - BACKGROUND: The International Breast Cancer Study Group conducted a phase III
      trial in Australian/New Zealand (ANZ) and Swiss/German/Austrian (SGA) centres on 
      training doctors in clear and ethical information delivery about treatment
      options and strategies to encourage shared decision making. METHODS: Medical,
      surgical, gynaecological and radiation oncologists, and their patients for whom
      adjuvant breast cancer therapy was indicated, were eligible. Doctors were
      randomised to participate in a workshop with standardised teaching material and
      role playing. Patients were recruited in the experimental and control groups
      before and after the workshop. RESULTS: In ANZ centres, 21 eligible doctors
      recruited a total of 304 assessable patients. In SGA centres, 41 doctors
      recruited 390 patients. The training was well accepted. There was no overall
      effect on patient decisional conflict (primary endpoint) 2 weeks after the
      consultation. Overall, patients were satisfied with their treatment decision,
      their consultation and their doctors' consultation skills. Considerable variation
      was observed in patient outcomes between SGA and ANZ centres; the effect sizes of
      the intervention were marginal (<0.2). CONCLUSIONS: Shared decision making
      remains a challenge. A sustained training effect may require more intensive
      training tailored to the local setting. Cross-cultural differences need attention
      in conducting trials on communication interventions.
CI  - Copyright (c) 2011 John Wiley & Sons, Ltd.
FAU - Bernhard, Jurg
AU  - Bernhard J
AD  - IBCSG Coordinating Center, Effingerstrasse 40, 3008, Bern, Switzerland.
      juerg.bernhard@ibcsg.org
FAU - Butow, Phyllis
AU  - Butow P
FAU - Aldridge, Julie
AU  - Aldridge J
FAU - Juraskova, Ilona
AU  - Juraskova I
FAU - Ribi, Karin
AU  - Ribi K
FAU - Brown, Richard
AU  - Brown R
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110825
PL  - England
TA  - Psychooncology
JT  - Psycho-oncology
JID - 9214524
SB  - IM
MH  - Adult
MH  - Attitude of Health Personnel
MH  - Australia
MH  - Breast Neoplasms/psychology/*therapy
MH  - Combined Modality Therapy
MH  - *Communication
MH  - Cross-Cultural Comparison
MH  - *Decision Making
MH  - Education, Medical, Continuing
MH  - Europe
MH  - Female
MH  - Humans
MH  - Male
MH  - New Zealand
MH  - *Outcome and Process Assessment, Health Care
MH  - *Patient Participation
MH  - Patient Satisfaction
MH  - Patient Simulation
MH  - Physician-Patient Relations
MH  - Physicians/psychology
MH  - Surveys and Questionnaires
EDAT- 2012/12/05 06:00
MHDA- 2013/04/04 06:00
CRDT- 2012/12/05 06:00
PHST- 2010/09/09 00:00 [received]
PHST- 2011/06/07 00:00 [revised]
PHST- 2011/06/08 00:00 [accepted]
PHST- 2012/12/05 06:00 [entrez]
PHST- 2012/12/05 06:00 [pubmed]
PHST- 2013/04/04 06:00 [medline]
AID - 10.1002/pon.2044 [doi]
PST - ppublish
SO  - Psychooncology. 2012 Dec;21(12):1265-74. doi: 10.1002/pon.2044. Epub 2011 Aug 25.


PMID- 23199170
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121204
LR  - 20211021
IS  - 1878-5085 (Electronic)
IS  - 1878-5077 (Linking)
VI  - 2
IP  - 4
DP  - 2011 Dec
TI  - European strategies in predictive, preventive and personalised medicine:
      highlights of the EPMA World Congress 2011.
PG  - 315-32
LID - 10.1007/s13167-011-0134-6 [doi]
AB  - This article highlights the central events of the EPMA World Congress 2011 - the 
      strategic meeting of the European Association for Predictive, Preventive and
      Personalised Medicine (PPPM). European strategies related to PPPM have been
      discussed in specialised sessions dedicated toHealthcare in overview across the
      globeCollaboration with global organisationsGranting strategies in PPPMEducation 
      in PPPMPatient needsTargeted preventionPPPM in reproductive medicine &
      paediatricsPPPM in diabetes carePPPM in neurodegenerative diseasesPPPM in
      cancerPPPM in cardiovascular diseasesInnovative PPPM-centresBiomarker validation 
      and standardsPatient-specific modelling and bioinformatics in PPPMPPPM-related
      bio-preservation, biobanking & ethicsEPMA "expert recommendations" will be
      presented to Ministries of Health of 44 contributing countries, partner
      societies, associations, funding agencies and global organisations that
      participated in the congress. Full analysis of the outcomes will be provided
      during the next EPMA World Congress in September 2013.
FAU - Golubnitschaja, Olga
AU  - Golubnitschaja O
AD  - European Association for Predictive, Preventive and Personalised Medicine (EPMA),
      Brussels, Belgium ; Department of Radiology, Friedrich-Wilhelms-University of
      Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany.
FAU - Costigliola, Vincenzo
AU  - Costigliola V
LA  - eng
PT  - Journal Article
DEP - 20111229
PL  - Switzerland
TA  - EPMA J
JT  - The EPMA journal
JID - 101517307
PMC - PMC3405403
EDAT- 2012/12/04 06:00
MHDA- 2012/12/04 06:01
CRDT- 2012/12/04 06:00
PHST- 2012/12/04 06:00 [entrez]
PHST- 2012/12/04 06:00 [pubmed]
PHST- 2012/12/04 06:01 [medline]
AID - 10.1007/s13167-011-0134-6 [doi]
AID - 134 [pii]
PST - ppublish
SO  - EPMA J. 2011 Dec;2(4):315-32. doi: 10.1007/s13167-011-0134-6. Epub 2011 Dec 29.


PMID- 23194327
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121203
LR  - 20211021
IS  - 1878-5085 (Electronic)
IS  - 1878-5077 (Linking)
VI  - 2
IP  - 4
DP  - 2011 Dec
TI  - Salutogenesis and Ayurveda: indications for public health management.
PG  - 459-65
LID - 10.1007/s13167-011-0132-8 [doi]
AB  - Ayurveda, the ancient traditional medicine of India, defines health as a state of
      complete physical, mental and spiritual well-being. The focus of Ayurveda is on a
      predictive, preventive and personalized medicine. This is obtained through a
      low-cost personalized counseling about lifestyle measures (diet, activities,
      etc.), trying to involve the patient directly in the process of healing,
      increasing his self-awareness and good relationships with other people and
      nature. The approach of Ayurveda toward positive health shares its features with 
      that of salutogenesis as described by Antonovsky. Prevention strategies
      pragmatically suggested by Ayurveda - including factors such as promotion of
      health education, individual awareness, integration of spirituality and ethics in
      healthcare system- may be applied in public health management, in order to
      improve perceived and objective life quality, promote healthy aging, limit drugs 
      use (avoiding expensive side-effects) and reduce chronic diseases social costs.
      Ayurveda has a universal-coverage, being person-centered and consequently
      intercultural.
FAU - Morandi, Antonio
AU  - Morandi A
AD  - Ayurvedic Point, C.SO Sempione 63, 20149 Milan, Italy ; SSIMA, Italian Scientific
      Society for Ayurvedic Medicine, C.SO Sempione 63, 20149 Milan, Italy.
FAU - Tosto, Carmen
AU  - Tosto C
FAU - Roberti di Sarsina, Paolo
AU  - Roberti di Sarsina P
FAU - Dalla Libera, Dacia
AU  - Dalla Libera D
LA  - eng
PT  - Journal Article
DEP - 20111201
PL  - Switzerland
TA  - EPMA J
JT  - The EPMA journal
JID - 101517307
PMC - PMC3405400
EDAT- 2012/12/01 06:00
MHDA- 2012/12/01 06:01
CRDT- 2012/12/01 06:00
PHST- 2011/08/31 00:00 [received]
PHST- 2011/11/02 00:00 [accepted]
PHST- 2012/12/01 06:00 [entrez]
PHST- 2012/12/01 06:00 [pubmed]
PHST- 2012/12/01 06:01 [medline]
AID - 10.1007/s13167-011-0132-8 [doi]
AID - 132 [pii]
PST - ppublish
SO  - EPMA J. 2011 Dec;2(4):459-65. doi: 10.1007/s13167-011-0132-8. Epub 2011 Dec 1.


PMID- 23193885
OWN - NLM
STAT- MEDLINE
DCOM- 20130108
LR  - 20121130
IS  - 1029-4864 (Print)
IS  - 1029-4864 (Linking)
VI  - 66
IP  - 10
DP  - 2011 Nov
TI  - Dental ethics case 17. What are my obligations and ethical responsibilities when 
      treating patients with HIV?
PG  - 482-3
FAU - Naidoo, S
AU  - Naidoo S
AD  - Department of Community Oral Health, University of the Western Cape, Private Bag 
      X1, Tygerberg, 7505. suenaidoo@uwc.ac.za
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - SADJ
JT  - SADJ : journal of the South African Dental Association = tydskrif van die
      Suid-Afrikaanse Tandheelkundige Vereniging
JID - 9812497
MH  - Confidentiality/ethics
MH  - Dental Care for Chronically Ill/*ethics
MH  - Dentists/*ethics
MH  - *Ethics, Dental
MH  - Female
MH  - *HIV Infections/transmission
MH  - Humans
MH  - Infectious Disease Transmission, Patient-to-Professional/prevention & control
MH  - Refusal to Treat/ethics
MH  - Social Responsibility
MH  - Young Adult
EDAT- 2012/12/01 06:00
MHDA- 2013/01/09 06:00
CRDT- 2012/12/01 06:00
PHST- 2012/12/01 06:00 [entrez]
PHST- 2012/12/01 06:00 [pubmed]
PHST- 2013/01/09 06:00 [medline]
PST - ppublish
SO  - SADJ. 2011 Nov;66(10):482-3.


PMID- 23193877
OWN - NLM
STAT- MEDLINE
DCOM- 20130108
LR  - 20141120
IS  - 1029-4864 (Print)
IS  - 1029-4864 (Linking)
VI  - 66
IP  - 9
DP  - 2011 Oct
TI  - Dental ethics case 16. Pull out my four front teeth...
PG  - 438
FAU - Naidoo, S
AU  - Naidoo S
AD  - Department of Community Oral Health, University of the Western Cape, Private Bag 
      X1, Tygerberg, 7505. suenaidoo@uwc.ac.za
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - SADJ
JT  - SADJ : journal of the South African Dental Association = tydskrif van die
      Suid-Afrikaanse Tandheelkundige Vereniging
JID - 9812497
MH  - Adolescent
MH  - Body Modification, Non-Therapeutic/*ethics
MH  - Dentist-Patient Relations/ethics
MH  - Dentists/*ethics
MH  - Elective Surgical Procedures/ethics
MH  - *Ethics, Dental
MH  - Female
MH  - Humans
MH  - Peer Group
MH  - Personal Autonomy
MH  - Social Responsibility
MH  - Tooth Extraction/*ethics
EDAT- 2012/12/01 06:00
MHDA- 2013/01/09 06:00
CRDT- 2012/12/01 06:00
PHST- 2012/12/01 06:00 [entrez]
PHST- 2012/12/01 06:00 [pubmed]
PHST- 2013/01/09 06:00 [medline]
PST - ppublish
SO  - SADJ. 2011 Oct;66(9):438.


PMID- 23193872
OWN - NLM
STAT- MEDLINE
DCOM- 20130108
LR  - 20191210
IS  - 1029-4864 (Print)
IS  - 1029-4864 (Linking)
VI  - 66
IP  - 9
DP  - 2011 Oct
TI  - An analysis of complaints against oral health professionals charged with
      misconduct at the HPCSA: 2004-2009.
PG  - 420-2, 424-5
AB  - AIM: This study investigates the nature, frequency, and outcome of complaints
      relating to misconduct laid against oral healthcare professionals (OHPs), charged
      with misconduct in South Africa. METHODS: Records of the Health Professions
      Council of South Africa (2004-2009) were analysed and classified using the
      ethical rules as a reference. "Clinically-related complaints" and "fraud" were
      added as extra categories. The nature and outcome of the complaints and the
      penalties were quantified, and the detailed nature of the complaints was
      qualitatively reported. RESULTS: Two percent of the registered dentists and 5.5% 
      of the registered dental therapists were charged with misconduct. Clinically
      related complaints (59%) and fraud (29%) were most prevalent amongst the accused 
      dentists. Fraud (46%), clinically related complaints (19%), advertising (15%),
      infection control (8%), and creating expectations that could not be met (8%) were
      the most common complaints against dental therapists. CONCLUSIONS: Substandard
      dental treatment and fraud were the main reasons for patient dissatisfaction that
      led to OHPs being charged with misconduct. Both these undesirable practices may
      be financially motivated. OHPs should take cognisance of these statistics and
      should adjust their professional approach accordingly in order to reflect
      acceptable ethical behaviour.
FAU - Postma, T C
AU  - Postma TC
AD  - Department of Dental Management Sciences, School of Dentistry, University of
      Pretoria, P.O. Box 1266, Pretoria, 0001, South Africa. corne.postma@up.ac.za
FAU - van Wyk, P J
AU  - van Wyk PJ
FAU - Heymans, J H
AU  - Heymans JH
FAU - White, J G
AU  - White JG
FAU - Prinsloo, P M
AU  - Prinsloo PM
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - SADJ
JT  - SADJ : journal of the South African Dental Association = tydskrif van die
      Suid-Afrikaanse Tandheelkundige Vereniging
JID - 9812497
MH  - Advertising/statistics & numerical data
MH  - Dental Auxiliaries/ethics/*statistics & numerical data
MH  - Dental Care/statistics & numerical data
MH  - Dentist-Patient Relations/ethics
MH  - Dentists/ethics/*statistics & numerical data
MH  - Ethics, Dental
MH  - Fraud/statistics & numerical data
MH  - Humans
MH  - Infection Control, Dental/statistics & numerical data
MH  - Malpractice/statistics & numerical data
MH  - Professional Misconduct/*statistics & numerical data
MH  - Retrospective Studies
MH  - South Africa
EDAT- 2012/12/01 06:00
MHDA- 2013/01/09 06:00
CRDT- 2012/12/01 06:00
PHST- 2012/12/01 06:00 [entrez]
PHST- 2012/12/01 06:00 [pubmed]
PHST- 2013/01/09 06:00 [medline]
PST - ppublish
SO  - SADJ. 2011 Oct;66(9):420-2, 424-5.


PMID- 23180206
OWN - NLM
STAT- MEDLINE
DCOM- 20131224
LR  - 20171105
IS  - 1176-7529 (Print)
IS  - 1176-7529 (Linking)
VI  - 9
IP  - 1
DP  - 2012 Mar
TI  - Ethical challenges in end-of-life care for GLBTI individuals.
PG  - 113-4
LID - 10.1007/s11673-011-9345-8 [doi]
FAU - Cartwright, Colleen
AU  - Cartwright C
AD  - ASLaRC Aged Services Unit, Southern Cross University, Brett St., Tweed Heads, NSW
      2485, Australia. colleen.cartwright@scu.edu.au
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20111222
PL  - Netherlands
TA  - J Bioeth Inq
JT  - Journal of bioethical inquiry
JID - 101250741
SB  - IM
CIN - J Bioeth Inq. 2012 Sep;9(3):361-3. PMID: 23180337
CIN - J Bioeth Inq. 2012 Sep;9(3):365-7. PMID: 23180338
MH  - Adult
MH  - Female
MH  - *Homosexuality, Female
MH  - Humans
MH  - Parents
MH  - Spouses
MH  - Terminal Care/ethics/*legislation & jurisprudence
MH  - United States
EDAT- 2012/11/28 06:00
MHDA- 2013/12/25 06:00
CRDT- 2012/11/27 06:00
PHST- 2011/11/26 00:00 [received]
PHST- 2011/11/30 00:00 [accepted]
PHST- 2012/11/27 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/12/25 06:00 [medline]
AID - 10.1007/s11673-011-9345-8 [doi]
PST - ppublish
SO  - J Bioeth Inq. 2012 Mar;9(1):113-4. doi: 10.1007/s11673-011-9345-8. Epub 2011 Dec 
      22.


PMID- 23180204
OWN - NLM
STAT- MEDLINE
DCOM- 20131224
LR  - 20211021
IS  - 1176-7529 (Print)
IS  - 1176-7529 (Linking)
VI  - 9
IP  - 1
DP  - 2012 Mar
TI  - Castration anxiety.
PG  - 85-91
LID - 10.1007/s11673-011-9341-z [doi]
AB  - Chemical castration laws, such as one recently adopted in the U.S. State of
      Louisiana, raise challenging ethical concerns for physicians. Even if such
      interventions were to prove efficacious, which is far from certain, they would
      still raise troubling concerns regarding the degree of medical risk that may be
      imposed upon prisoners in the name of public safety as well as the appropriate
      role for physicians and other health care professionals in the administration of 
      pharmaceuticals to competent prisoners over the inmates' unequivocal objections. 
      This paper argues that the concerns raised by chemical castration are grave
      enough that, until they are adequately addressed by policymakers, physicians
      ought not to participate in the process.
FAU - Appel, Jacob M
AU  - Appel JM
AD  - jacobmappel@gmail.com
LA  - eng
PT  - Journal Article
DEP - 20111222
PL  - Netherlands
TA  - J Bioeth Inq
JT  - Journal of bioethical inquiry
JID - 101250741
RN  - C2QI4IOI2G (Medroxyprogesterone Acetate)
SB  - IM
MH  - Child
MH  - Child Abuse, Sexual/legislation & jurisprudence
MH  - Humans
MH  - Louisiana
MH  - Male
MH  - Medroxyprogesterone Acetate/*adverse effects/therapeutic use
MH  - *Orchiectomy/adverse effects/ethics/legislation & jurisprudence
MH  - *Prisoners
MH  - Sex Offenses/*legislation & jurisprudence
EDAT- 2012/11/28 06:00
MHDA- 2013/12/25 06:00
CRDT- 2012/11/27 06:00
PHST- 2010/02/08 00:00 [received]
PHST- 2011/10/12 00:00 [accepted]
PHST- 2012/11/27 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/12/25 06:00 [medline]
AID - 10.1007/s11673-011-9341-z [doi]
PST - ppublish
SO  - J Bioeth Inq. 2012 Mar;9(1):85-91. doi: 10.1007/s11673-011-9341-z. Epub 2011 Dec 
      22.


PMID- 23180203
OWN - NLM
STAT- MEDLINE
DCOM- 20131224
LR  - 20211021
IS  - 1176-7529 (Print)
IS  - 1176-7529 (Linking)
VI  - 9
IP  - 1
DP  - 2012 Mar
TI  - Ethical issues in new drug prescribing.
PG  - 77-83
LID - 10.1007/s11673-011-9342-y [doi]
AB  - We use the format of a hypothetical case study to review issues related to
      pharmaceutical product approval and physician prescribing practices. In this
      case, a new FDA-approved drug is recommended for a patient who subsequently
      experiences an adverse event that may or may not be related to the prescription. 
      This case raises a number of ethical and legal considerations physicians
      routinely face when deciding whether to recommend such drugs for their patients. 
      Despite the need for ongoing observation by the regulatory apparatus, physicians 
      should be cognizant of the limitations of the drug approval system and the
      post-approval prescription drug surveillance system. We discuss physicians'
      ethical obligations when faced with a newly approved drug, including seeking out 
      independent sources of learning, reporting adverse effects, and notifying
      patients about limitations in available knowledge about therapeutic
      recommendations.
FAU - Cole, Lindsay W
AU  - Cole LW
AD  - Harvard Medical School, Boston, MA, USA.
FAU - Kesselheim, Jennifer C
AU  - Kesselheim JC
FAU - Kesselheim, Aaron S
AU  - Kesselheim AS
LA  - eng
GR  - K08HS18465-01/HS/AHRQ HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20111215
PL  - Netherlands
TA  - J Bioeth Inq
JT  - Journal of bioethical inquiry
JID - 101250741
RN  - 0 (Prescription Drugs)
SB  - IM
MH  - Conflict of Interest
MH  - Disclosure/*ethics
MH  - Drug Approval
MH  - Drug Industry/*ethics
MH  - Ethics, Medical
MH  - Humans
MH  - Informed Consent
MH  - Interprofessional Relations/*ethics
MH  - Off-Label Use/*ethics
MH  - Physicians, Primary Care/*ethics
MH  - Practice Patterns, Physicians'/*ethics
MH  - Prescription Drugs/*therapeutic use
MH  - United States
MH  - United States Food and Drug Administration
EDAT- 2012/11/28 06:00
MHDA- 2013/12/25 06:00
CRDT- 2012/11/27 06:00
PHST- 2011/05/24 00:00 [received]
PHST- 2011/09/26 00:00 [accepted]
PHST- 2012/11/27 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/12/25 06:00 [medline]
AID - 10.1007/s11673-011-9342-y [doi]
PST - ppublish
SO  - J Bioeth Inq. 2012 Mar;9(1):77-83. doi: 10.1007/s11673-011-9342-y. Epub 2011 Dec 
      15.


PMID- 23180202
OWN - NLM
STAT- MEDLINE
DCOM- 20131224
LR  - 20211021
IS  - 1176-7529 (Print)
IS  - 1176-7529 (Linking)
VI  - 9
IP  - 1
DP  - 2012 Mar
TI  - Psychiatric ethics and a politics of compassion.
PG  - 67-75
LID - 10.1007/s11673-011-9346-7 [doi]
AB  - Australia has one of the harshest regimes for the processing of asylum seekers,
      people who have applied for refugee status but are still awaiting an answer. It
      has received sharp rebuke for its policies from international human rights bodies
      but continues to exercise its resolve to protect its borders from those seeking
      protection. One means of doing so is the detention of asylum seekers who arrive
      in Australia by boat. Health care providers who care for asylum seekers in these 
      conditions experience a conflict of "dual loyalty," whereby their role in
      preserving and maintaining the health of patients can run counter to their
      employment in detention facilities. Many psychiatrists who have worked in the
      detention setting engage in forms of political activism in order to change the
      process of seeking refuge.
FAU - Zion, Deborah
AU  - Zion D
AD  - International Public Health Unit, School of Public Health and Preventive
      Medicine, Monash University, Melbourne, Australia. Deborah.zion@monash.edu
FAU - Briskman, Linda
AU  - Briskman L
FAU - Loff, Bebe
AU  - Loff B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111224
PL  - Netherlands
TA  - J Bioeth Inq
JT  - Journal of bioethical inquiry
JID - 101250741
SB  - IM
MH  - Australia
MH  - Conflict of Interest
MH  - Delivery of Health Care/trends
MH  - Emigration and Immigration/legislation & jurisprudence
MH  - *Empathy
MH  - Ethics, Medical
MH  - Humans
MH  - Mental Disorders/*therapy
MH  - Physician-Patient Relations
MH  - Politics
MH  - Prisons
MH  - Psychiatry/*ethics
MH  - Public Policy
MH  - Refugees/legislation & jurisprudence/*psychology
EDAT- 2012/11/28 06:00
MHDA- 2013/12/25 06:00
CRDT- 2012/11/27 06:00
PHST- 2011/02/23 00:00 [received]
PHST- 2011/11/08 00:00 [accepted]
PHST- 2012/11/27 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/12/25 06:00 [medline]
AID - 10.1007/s11673-011-9346-7 [doi]
PST - ppublish
SO  - J Bioeth Inq. 2012 Mar;9(1):67-75. doi: 10.1007/s11673-011-9346-7. Epub 2011 Dec 
      24.


PMID- 23134278
OWN - NLM
STAT- MEDLINE
DCOM- 20131204
LR  - 20121108
IS  - 1440-1800 (Electronic)
IS  - 1320-7881 (Linking)
VI  - 19
IP  - 4
DP  - 2012 Dec
TI  - Trappings of technology: casting palliative care nursing as legal relations.
PG  - 334-44
LID - 10.1111/j.1440-1800.2011.00568.x [doi]
AB  - Community palliative care nurses in Perth have joined the throng of healthcare
      workers relying on personal digital assistants (PDAs) to store, access and send
      client information in 'real time'. This paper is guided by Heidegger's approach
      to technologies and Habermas' insights into the role of law in administering
      social welfare programs to reveal how new ethical and legal understandings
      regarding patient information add to nursing's professional responsibilities.
      This qualitative research interprets data from interviews with twenty community
      palliative care nurses about clients' legal rights to informational privacy and
      confidentiality. It explores nurses' views of their nursing responsibilities
      regarding clients' legal rights, liability issues, bureaucratic monitoring and
      enforcement procedures. It concludes that nurses and clients are construed as
      legal subjects entrenched in legal relations that have magnified since these
      nurses began using PDAs in 2005/2006.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Larsen, Ann-Claire
AU  - Larsen AC
AD  - School of Law and Justice, Edith Cowan University, Joondalup, WA 6027, Australia.
      a.larsen@ecu.edu.au
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110815
PL  - Australia
TA  - Nurs Inq
JT  - Nursing inquiry
JID - 9505881
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - *Attitude to Computers
MH  - Australia
MH  - *Community Health Nursing
MH  - *Computers, Handheld
MH  - Confidentiality/*ethics/*legislation & jurisprudence
MH  - Female
MH  - Humans
MH  - Interviews as Topic
MH  - Liability, Legal
MH  - Middle Aged
MH  - Nurse-Patient Relations
MH  - Nursing Methodology Research
MH  - *Palliative Care
MH  - Qualitative Research
EDAT- 2012/11/09 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/11/09 06:00
PHST- 2012/11/09 06:00 [entrez]
PHST- 2012/11/09 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1111/j.1440-1800.2011.00568.x [doi]
PST - ppublish
SO  - Nurs Inq. 2012 Dec;19(4):334-44. doi: 10.1111/j.1440-1800.2011.00568.x. Epub 2011
      Aug 15.


PMID- 23120819
OWN - NLM
STAT- MEDLINE
DCOM- 20121127
LR  - 20220330
IS  - 1330-0164 (Print)
IS  - 1330-0164 (Linking)
VI  - 65 Suppl 3
DP  - 2011 Oct
TI  - [Attitudes towards transplantation and organ donation in high school graduates of
      math gymnasium in Osijek].
PG  - 63-6
AB  - OBJECTIVE: Testing attitudes and opinions ofgraduate students in Osijek towards
      organ donation and transplantation. Examinees and methods: The research included 
      99 students of math gymnasium in Osijek (54 males and 45 females, mean age 18
      years). They fulfilled an anonymous questionnaire, consisted of 24 questions
      about transplantation, willingness to donate organs, consciousness of importance 
      of donating organs and attitudes of religion towards organ donation. Statistical 
      analysis was made by SPSS 16.0 computer program using Chi-square test. RESULTS:
      Most of the gymnasium students (80.8%) have already heard about organ donation,
      76.8% of them have received information by television. 59.4% students know how a 
      transplantation is being performed, but the majority (64.6%) of them don't know
      whom to address to receive additional information about organ donation. 27.3%
      students have discussed transplantation inside their families and 17.2% examinees
      know someone who signed the donor card. 55.6% examinees are convinced that
      transplantation procedure is safe and efficient. 41.4% thinks that family should 
      give permission for explantation of a deceased patient's organs, while 33.3%
      consider it not necessary. Regarding the question whether examinees think that
      organ transplantation was a mutilation, 91.9% of them answered "no". Although
      55.6% students believe that doctors would put the same effort in saving patients,
      independent whether they possessed donor card or not, there were 60.6% that
      thought it was possible to obtain organ in Croatia by illegal ways. Nevertheless,
      79.8% students would receive organ from a deceased person, 64.6% would donate
      organs after their death. Observing ethical and religious attitudes, 92.9% are
      sure that organ donation is a humane gesture. 82.8% examinees were believers and 
      60.6% of them didn't know attitudes of their religion towards organ donation.
      Women have significantly more willingness to donate their organ to family member 
      during their lives (97.8%), while 81.5% males would do the same, p=0.035. Lower
      percentage of atheists were found among women (6.7%) than in men (25.9%),
      p=0.011. 53.7% males consider their religion to be against organ donation, while 
      only 17.8% females, p=0.046. CONCLUSION: High school graduates have mostly heard 
      about organ transplantation (many of them by television) and the majority has
      positive attitude and are willing to donate theirs and to receive organs from
      another person. Such willingness and tendency towards organ donation should be
      taken with reserve, because it was relatively young population, without life
      experience in similar situations. Within their population, believers are
      predominating, and they often don't know whether their religion is pro organ
      donation or against it. Smaller proportion, but still the majority of the
      examinees, considers the transplantation to be a safe procedure. Women and men
      show differences regarding information, attitudes and willingness to make a
      sacrifice. Women are more willing to donate organs to a family member. Still,
      there is not enough discussion about transplantation inside each family. Rate of 
      ignorance and lack of information about transplantation and organ donation,
      indicates a need for better representation of this topic in media, schools,
      religious institutions and inside family.
FAU - Lada, Zibar
AU  - Lada Z
AD  - Department for Dialysis, Clinical Hospital Center Osijek, Osijek, Croatia.
      lada.zibar@mefos.hr
FAU - Zvonimir, Popovic
AU  - Zvonimir P
FAU - Nikola, Raguz Lucic
AU  - Nikola RL
FAU - Vlasta, Orlic Karbic
AU  - Vlasta OK
LA  - hrv
PT  - English Abstract
PT  - Journal Article
TT  - Stavovi o transplantaciji i doniranju organa u maturanata osjecke matematicke
      gimnazije.
PL  - Croatia
TA  - Acta Med Croatica
JT  - Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti
JID - 9208249
SB  - IM
MH  - Adolescent
MH  - *Attitude
MH  - Croatia
MH  - Humans
MH  - Male
MH  - Students/*psychology
MH  - Surveys and Questionnaires
MH  - *Tissue and Organ Procurement
MH  - Transplantation/*psychology
EDAT- 2012/11/06 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/11/06 06:00
PHST- 2012/11/06 06:00 [entrez]
PHST- 2012/11/06 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
PST - ppublish
SO  - Acta Med Croatica. 2011 Oct;65 Suppl 3:63-6.


PMID- 23115497
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130207
LR  - 20211021
IS  - 1918-1485 (Electronic)
IS  - 1205-7088 (Linking)
VI  - 16
IP  - 9
DP  - 2011 Nov
TI  - Drug research and treatment for children in Canada: A challenge.
PG  - 560-1
AB  - Historically, children have been 'therapeutic orphans'. Many drugs have not been 
      studied or labelled for use in children and adolescents, making the development
      and definition of optimally safe and effective drug therapies for the paediatric 
      age group an ongoing challenge. Over the past decade, networks have developed in 
      the United States and Europe to enhance drug research for this group, while no
      comparable evolution has occurred in Canada. The present statement provides
      context for the Canadian situation and makes recommendations that address two
      pressing needs: for more drug research focused on Canadian children and
      adolescents, including dedicated support for such research; and for increasing
      human capacity to undertake targeted studies. These initiatives should be
      undertaken collaboratively, nationally and internationally, and include
      strategic, innovative approaches to the unique problems and ethical issues posed 
      by drug research in this population.
FAU - Rieder, Michael J
AU  - Rieder MJ
CN  - Canadian Paediatric Society, Drug Therapy and Hazardous Substances Committee
LA  - eng
LA  - fre
PT  - Journal Article
PL  - England
TA  - Paediatr Child Health
JT  - Paediatrics & child health
JID - 9815960
PMC - PMC3223893
OTO - NOTNLM
OT  - Canada
OT  - Children
OT  - Drugs
OT  - Research
EDAT- 2012/11/02 06:00
MHDA- 2012/11/02 06:01
CRDT- 2012/11/02 06:00
PHST- 2012/11/02 06:00 [entrez]
PHST- 2012/11/02 06:00 [pubmed]
PHST- 2012/11/02 06:01 [medline]
AID - 10.1093/pch/16.9.560 [doi]
PST - ppublish
SO  - Paediatr Child Health. 2011 Nov;16(9):560-1. doi: 10.1093/pch/16.9.560.


PMID- 23101728
OWN - NLM
STAT- MEDLINE
DCOM- 20131114
LR  - 20151119
IS  - 1532-8449 (Electronic)
IS  - 0882-5963 (Linking)
VI  - 27
IP  - 6
DP  - 2012 Dec
TI  - Explicating caregiving by mothers of children with complex needs in ireland: a
      phenomenological study.
PG  - 642-51
LID - 10.1016/j.pedn.2011.07.003 [doi]
LID - S0882-5963(11)00529-X [pii]
AB  - This qualitative phenomenological study explored mothers' experiences of caring
      for a child with complex needs. After ethical approval was obtained, data were
      collected through 11 diaries and 48 interviews with 17 mothers in Ireland. Caring
      for a child with complex needs involves the delivery of care in an inside world
      of the home, the world outside the home, and a "going-between" world. Caregiving,
      1 of 8 closely linked dimensions, is presented, including its 4 categories. These
      are normal mothering, technical caregiving, preemptive caregiving, and
      individualized caregiving. Professionals require a greater understanding of the
      experiences of mothers caring for children with complex needs at home.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Nicholl, Honor M
AU  - Nicholl HM
AD  - School of Nursing and Midwifery, Trinity College Dublin, Dublin, Ireland.
      nichollh@tcd.ie
FAU - Begley, Cecily M
AU  - Begley CM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110906
PL  - United States
TA  - J Pediatr Nurs
JT  - Journal of pediatric nursing
JID - 8607529
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Caregivers/*psychology
MH  - Child
MH  - Child, Preschool
MH  - Developmental Disabilities/nursing/*rehabilitation
MH  - Disability Evaluation
MH  - Disabled Children/*rehabilitation
MH  - Female
MH  - Humans
MH  - Interviews as Topic
MH  - Ireland
MH  - Male
MH  - *Maternal Behavior
MH  - Mother-Child Relations
MH  - Needs Assessment
MH  - Qualitative Research
MH  - Quality of Life
MH  - Risk Assessment
MH  - Stress, Psychological
MH  - Surveys and Questionnaires
MH  - Vulnerable Populations/statistics & numerical data
EDAT- 2012/10/30 06:00
MHDA- 2013/11/15 06:00
CRDT- 2012/10/30 06:00
PHST- 2010/12/01 00:00 [received]
PHST- 2011/07/05 00:00 [revised]
PHST- 2011/07/06 00:00 [accepted]
PHST- 2012/10/30 06:00 [entrez]
PHST- 2012/10/30 06:00 [pubmed]
PHST- 2013/11/15 06:00 [medline]
AID - S0882-5963(11)00529-X [pii]
AID - 10.1016/j.pedn.2011.07.003 [doi]
PST - ppublish
SO  - J Pediatr Nurs. 2012 Dec;27(6):642-51. doi: 10.1016/j.pedn.2011.07.003. Epub 2011
      Sep 6.


PMID- 23051119
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121210
LR  - 20160519
IS  - 1876-2026 (Electronic)
IS  - 1876-2018 (Linking)
VI  - 4
IP  - 3
DP  - 2011 Sep
TI  - Portrayal of psychiatrists in Hindi movies released in the first decade of the
      21st century.
PG  - 210-3
LID - 10.1016/j.ajp.2011.07.001 [doi]
AB  - CONTEXT: Of late, there has been an increase in the number of psychiatrists shown
      in Hindi movies. There is dearth of systematic research that focuses specifically
      upon the depiction of psychiatrists in Hindi cinema. AIM: To explore the
      portrayal of psychiatrists in recent Hindi cinema. MATERIALS AND METHODS:
      Twenty-six Hindi movies released between January 2001 and March 2010 portraying
      33 'psychiatrist' characters in a main or a secondary (but significant) role,
      were reviewed and data related to the personal attributes and professional
      conduct of the movie psychiatrists was collected. RESULTS AND CONCLUSIONS: The
      portrayal of psychiatrists in Hindi movies released in the first decade of the
      21st century is unflattering. Hindi movies depicted psychiatrists as most likely 
      to be male, middle-aged, and friendly in their attitude towards the patients.
      42.4% of them were clinically incompetent, and only 30.3% could make an accurate 
      diagnosis. 39.4% of them breached professional ethics. Eight (24. 2%)
      transgressed non-sexual boundaries, whereas five (15.2%) violated both sexual and
      non-sexual boundaries. The most common clinical/treatment setting was outpatient 
      (53.8%), and pharmacotherapy was the most common treatment modality used.
      Treatment outcome was depicted positive in only 23.1% of the movies analyzed.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Banwari, Girish H
AU  - Banwari GH
AD  - Department of Psychiatry, ESIC Model Hospital, Ahmedabad, India.
LA  - eng
PT  - Journal Article
DEP - 20110908
PL  - Netherlands
TA  - Asian J Psychiatr
JT  - Asian journal of psychiatry
JID - 101517820
EDAT- 2012/10/12 06:00
MHDA- 2012/10/12 06:01
CRDT- 2012/10/12 06:00
PHST- 2011/02/19 00:00 [received]
PHST- 2011/06/27 00:00 [revised]
PHST- 2011/07/04 00:00 [accepted]
PHST- 2012/10/12 06:00 [entrez]
PHST- 2012/10/12 06:00 [pubmed]
PHST- 2012/10/12 06:01 [medline]
AID - S1876-2018(11)00083-9 [pii]
AID - 10.1016/j.ajp.2011.07.001 [doi]
PST - ppublish
SO  - Asian J Psychiatr. 2011 Sep;4(3):210-3. doi: 10.1016/j.ajp.2011.07.001. Epub 2011
      Sep 8.


PMID- 23030819
OWN - NLM
STAT- MEDLINE
DCOM- 20130319
LR  - 20180111
IS  - 1573-661X (Electronic)
IS  - 0147-7307 (Linking)
VI  - 36
IP  - 5
DP  - 2012 Oct
TI  - The constant multiplier assumption misestimates long-term sex offender recidivism
      rates.
PG  - 390-393
LID - 10.1037/h0093924 [doi]
AB  - Many clinical psychologists have claimed that long-term sexual recidivism rates
      are a fixed multiple of short-term rates and have estimated that the true value
      of this constant falls somewhere between 1.5 and 3.0. They have also proposed
      that it is "mathematically sound" for evaluators to estimate the long-term rate
      for any actuarial score in sexually violent predator civil commitment cases by
      multiplying its short-term rate by this constant. The present paper questions the
      "constant multiplier assumption" and summarizes disconfirming data collected by
      its proponents and others showing that the fixed ratios for groups with low
      short-term rates are actually greater than the ratios for groups with high
      short-term rates. These results rule out the use of the constant multiplier
      assumption by risk evaluators. It is concerning that this assumption has not been
      previously tested. The authors call on the developers of risk assessment systems 
      to collect and report data that clearly validate the assumptions that underpin
      their actuarial tables before they are disseminated or administered. The American
      Psychological Association ethical standards also require forensic evaluators to
      acknowledge the limitations of their risk assessments when they testify, a
      practice that is invaluable to the trier of fact.
CI  - PsycINFO Database Record (c) 2012 APA, all rights reserved.
FAU - Wollert, Richard
AU  - Wollert R
AD  - Department of Psychology, Washington State University Vancouver.
FAU - Cramer, Elliot
AU  - Cramer E
AD  - Department of Psychology, University of North Carolina.
LA  - eng
PT  - Journal Article
DEP - 20111128
PL  - United States
TA  - Law Hum Behav
JT  - Law and human behavior
JID - 7801255
SB  - IM
MH  - Forensic Psychiatry
MH  - Humans
MH  - Male
MH  - Models, Statistical
MH  - Recurrence
MH  - Risk Assessment/methods/*statistics & numerical data
MH  - Sex Offenses/*prevention & control/statistics & numerical data/*trends
MH  - United States
EDAT- 2012/10/04 06:00
MHDA- 2013/03/21 06:00
CRDT- 2012/10/04 06:00
PHST- 2012/10/04 06:00 [entrez]
PHST- 2012/10/04 06:00 [pubmed]
PHST- 2013/03/21 06:00 [medline]
AID - 2011-27251-001 [pii]
AID - 10.1037/h0093924 [doi]
PST - ppublish
SO  - Law Hum Behav. 2012 Oct;36(5):390-393. doi: 10.1037/h0093924. Epub 2011 Nov 28.


PMID- 23022838
OWN - NLM
STAT- MEDLINE
DCOM- 20121204
LR  - 20220408
IS  - 2008-6520 (Print)
IS  - 2008-6520 (Linking)
VI  - 2
IP  - 4
DP  - 2011 Oct
TI  - Precautions for health care workers to avoid hepatitis B and C virus infection.
PG  - 191-8
AB  - The burden of exposure to blood-borne pathogens (such as hepatitis B and C
      viruses) is considerable for health care workers. Hepatitis virus transmission
      requires a non-immune host, an infectious source, and skin or mucous membrane
      injury. These three aspects are the main fields for preventional interventions.
      We reviewed major recent studies on this topic to identify precautions health
      care workers should take to avoid hepatitis B (HBV) and C virus (HCV) infections.
      Accordingly, this review looks at aspects of epidemiology, risk factors, economy,
      knowledge, attitudes, practice, and ethics of HBV and HCV that affect health care
      workers. The risk of transmission depends on the load of pathogen, infectious
      characteristics and exposure frequency. Health care workers skill levels and the 
      specific hospital department involved appear to be the most important factors in 
      the exposure of health care workers to blood-borne pathogens. However, many
      health care workers surveyed, believed that educational programs about standard
      precautions in their setting were not adequate. Obviously, more detailed studies 
      will be needed to clarify risks and opportunities for health care workers
      precautions aimed at avoiding HBV and HCV infection, especially in emerging
      health research communities.
FAU - Askarian, M
AU  - Askarian M
AD  - Department of Community Medicine, Shiraz University of Medical Sciences, Iran.
      askariam@sums.ac.ir
FAU - Yadollahi, M
AU  - Yadollahi M
FAU - Kuochak, F
AU  - Kuochak F
FAU - Danaei, M
AU  - Danaei M
FAU - Vakili, V
AU  - Vakili V
FAU - Momeni, M
AU  - Momeni M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Iran
TA  - Int J Occup Environ Med
JT  - The international journal of occupational and environmental medicine
JID - 101535763
SB  - IM
MH  - Blood-Borne Pathogens
MH  - Health Knowledge, Attitudes, Practice
MH  - *Health Personnel
MH  - Hepatitis B/*transmission
MH  - Hepatitis C/*transmission
MH  - Humans
MH  - Infection Control/*methods
MH  - Infectious Disease Transmission, Patient-to-Professional/*prevention & control
MH  - Needlestick Injuries/prevention & control
MH  - Occupational Exposure/*prevention & control
MH  - Risk Factors
EDAT- 2012/10/02 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/10/02 06:00
PHST- 2011/08/07 00:00 [received]
PHST- 2011/09/11 00:00 [accepted]
PHST- 2012/10/02 06:00 [entrez]
PHST- 2012/10/02 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 111 [pii]
PST - ppublish
SO  - Int J Occup Environ Med. 2011 Oct;2(4):191-8.


PMID- 22990877
OWN - NLM
STAT- MEDLINE
DCOM- 20130401
LR  - 20120919
IS  - 1578-2735 (Electronic)
IS  - 1139-9287 (Linking)
VI  - 39 Suppl 3
DP  - 2011 Dec
TI  - Perception, experience and body identity.
PG  - 3-118
AB  - Physician has to know the patient in the disease and not only the disease in the 
      patient, from the dual perspective of the body as object and the body as subject.
      This also affects the patient who has to cope with the reality of having a body
      that bursts into the subject's consciousness as a vital threat, as source of
      discomfort and inability and being a body (Marcel). The human body in its dual
      aspect has been and is a great unknown, if not a great outrage in spite of the
      fact that we are our body and our body is each of us. We sometimes do not feel as
      we are and thus a confrontation arises, sometimes more normal, others more
      morbid. This forces the physician to face complex ethics considerations and the
      scientist to accept a personal identity disorder. Dualism considers that there
      are two substances in us, one that distinguishes us from other beings and from
      the rest of the individuals of the human species, the soul, the psychic life,
      mind or consciousness, and another more insubstancial one, the body. The aim of
      the first substance is to dominate the body, to survive it after death when it
      is, already a corpse is meant to become putrefied, is buried, incinerated or
      thrown to the depth of the sea. This dualism aims to explain the origin of the
      evil and the attitude to defeat it and it does so efficiently. This anthropology 
      has very ancient roots (the Upvanishads, in the orphic texts, in Plato), it is
      the core of Gnostic thought and the foundation of the modern science since
      Descartes. Some monist perspectives are a masked dualism or a mereologic fallacy,
      according to which, the brain is conscious, when that what is conscious is the
      subject, although the subject, with the brain could not be conscious. Therefore, 
      a new perspective is proposed, chiasmatic or janicular monism, that considers the
      adaptive value of focusing on the reality from two perspectives, as physical
      universe and the world of interpersonal relationships. In the agnosias and in the
      phantom limb there is a confrontation between the body object and the body
      subject that has made it possible to investigate how the perception of the own
      body is and how the brain generates the schema and the body image. The study of
      the body experience, from the phenomenology and the anthropological psychiatry
      perspective, has made it possible to go greater in-depth into the knowledge of
      the alterations of the experience of the own body in different mental diseases,
      especially in those in which a confrontation between the body and the personal
      identity arises makes it necessary to consider the process of individual
      identification and a category of personal identity disorders that would include
      body dysmorphic disorder, erythrophobia, anorexia nervosa, body integrity
      identity as well as the gender-type disorders (transsexualism, nonfetishistic
      transvestism, gender identity disorder during childhood). Key words: Dualism,
      Monism, Agnosia, Phantom limb, Cenesthesia, Body schema, Body image, Body
      experience, Personal identity disorders, Body dysmorphic disorder, Anorexia
      nervosa, Personal integrity identity disorder.
FAU - Lopez-Ibor, Juan J
AU  - Lopez-Ibor JJ
AD  - Instituto de Psiquiatria y Salud Mental Hospital Clinico San Carlos Psychiatry,
      Department Facultad de Medicina, Universidad Complutense Centro para la
      Investigacion Biomedica en Red en Salud Mental, Instituto de Investigacion
      Sanitaria del Hospital Clinico San Carlos, Madrid, Spain Fundacion Juan Jose
      Lopez-Ibor, Madrid.
FAU - Ortiz, Tomas
AU  - Ortiz T
FAU - Lopez-Ibor, Maria I
AU  - Lopez-Ibor MI
LA  - eng
LA  - spa
PT  - Journal Article
DEP - 20111201
PL  - Spain
TA  - Actas Esp Psiquiatr
JT  - Actas espanolas de psiquiatria
JID - 100886502
SB  - IM
MH  - Body Image/*psychology
MH  - Brain/physiology
MH  - Humans
MH  - Mental Disorders/*psychology
MH  - *Self Concept
EDAT- 2012/09/26 06:00
MHDA- 2013/04/02 06:00
CRDT- 2012/09/20 06:00
PHST- 2011/12/01 00:00 [received]
PHST- 2011/12/01 00:00 [accepted]
PHST- 2012/09/20 06:00 [entrez]
PHST- 2012/09/26 06:00 [pubmed]
PHST- 2013/04/02 06:00 [medline]
PST - ppublish
SO  - Actas Esp Psiquiatr. 2011 Dec;39 Suppl 3:3-118. Epub 2011 Dec 1.


PMID- 22909920
OWN - NLM
STAT- MEDLINE
DCOM- 20121018
LR  - 20131121
IS  - 0334-0139 (Print)
IS  - 0334-0139 (Linking)
VI  - 24
IP  - 2
DP  - 2011 Nov 4
TI  - The need for evidence-based, non-drug medicine.
PG  - 113-9
LID - 10.1515/ijamh.2012.017 [doi]
LID - /j/ijamh.2012.24.issue-2/ijamh.2012.017/ijamh.2012.017.xml [pii]
AB  - Evidence-based medicine (EBM) is defined as "the integration of best research
      evidence with clinical expertise and patient values." EBM is based on three
      equally important key factors: i) the best available scientific evidence; ii) the
      physician's experience and intuition; and, iii) the preferences and values of the
      patient. EBM uses a hierarchy of evidence and critical appraisal of the sources, 
      which makes it possible to balance high quality evidence with documented
      effectiveness. A treatment that is more safe and effective, but less well
      documented may very well be the treatment of choice. Ethics (not putting the
      patient at risk of harm with a treatment if this can be avoided at all) is an
      important part of EBM. Many pharmaceutical drugs have a number needed to treat
      (NNT) of approximately 20 [NNT=20, confidence interval CI (5-50)] and the number 
      needed to harm is less well understood and documented. The adverse effect profile
      of pharmacological agents can be more harmful than non-drug medicine. Most
      EBM-treatments are likely to be non-drug treatments in the future. There are six 
      steps to the practice of EBM: i) the patients and the physician must work
      together to define the problem; ii) the patients and the physician must explore
      the patient's values and preferences; iii) the information about the possible
      alternative medical interventions must be discussed and critically appraised; iv)
      the best, relevant evidence must be applied to the patient as a treatment or
      cure; v) together, the patient and the physician must evaluate how useful the
      intervention was; and vi) if the intervention did not help sufficiently, the
      process must begin again. In this review, we explain, in our opinion, how
      non-drug EBM should be practiced.
FAU - Ventegodt, Soren
AU  - Ventegodt S
AD  - Quailty of Life Research Center, Copenhagen, Denmark. ventegodt@livskvalitet.org
FAU - Orr, Gary
AU  - Orr G
FAU - Merrick, Joav
AU  - Merrick J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20111104
PL  - Germany
TA  - Int J Adolesc Med Health
JT  - International journal of adolescent medicine and health
JID - 8506960
SB  - IM
MH  - Biomedical Research/standards
MH  - Clinical Competence/standards
MH  - *Complementary Therapies/ethics/methods/psychology
MH  - Drug-Related Side Effects and Adverse Reactions
MH  - *Evidence-Based Medicine/methods/organization & administration
MH  - Humans
MH  - Patient Participation/psychology
MH  - Patient Preference/psychology
MH  - Patient Safety/standards
MH  - Physician-Patient Relations/ethics
MH  - Treatment Outcome
EDAT- 2012/08/23 06:00
MHDA- 2012/10/19 06:00
CRDT- 2012/08/23 06:00
PHST- 2011/02/15 00:00 [received]
PHST- 2011/05/02 00:00 [accepted]
PHST- 2012/08/23 06:00 [entrez]
PHST- 2012/08/23 06:00 [pubmed]
PHST- 2012/10/19 06:00 [medline]
AID - 10.1515/ijamh.2012.017 [doi]
AID - /j/ijamh.2012.24.issue-2/ijamh.2012.017/ijamh.2012.017.xml [pii]
PST - epublish
SO  - Int J Adolesc Med Health. 2011 Nov 4;24(2):113-9. doi: 10.1515/ijamh.2012.017.


PMID- 22909918
OWN - NLM
STAT- MEDLINE
DCOM- 20121018
LR  - 20130125
IS  - 0334-0139 (Print)
IS  - 0334-0139 (Linking)
VI  - 24
IP  - 2
DP  - 2012
TI  - Adolescent suicide in New York City: plenty of room for new research.
PG  - 99-104
LID - 10.1515/ijamh.2012.015 [doi]
LID - /j/ijamh.2012.24.issue-2/ijamh.2012.015/ijamh.2012.015.xml [pii]
AB  - The act of adolescent suicide continues to threaten adolescent populations in New
      York City (NYC). Consistent positive correlations have been found between a
      plethora of risk factors present in NYC adolescent populations and suicidal
      ideations and behaviors. Psychiatric conditions that may contribute to the rate
      of adolescent suicide in NYC include depression, bipolar disorder, substance
      abuse and schizophrenia. Unique factors that have been found to contribute to
      increased rates of completed suicides in NYC include the phenomena of railway
      suicides and suicide tourism. Homelessness and income inequality in NYC have also
      been consistently correlated with increased suicidality; with one study finding
      suicide attempts reported by a significant percentage of new admissions to
      homeless shelters. Adolescent populations in NYC that have been identified as
      particularly vulnerable to suicidality include runaway youth, homosexual youth,
      victimized adolescents and adolescents with a recent history of posttraumatic
      stress disorder (PTSD). Longitudinal studies in NYC have found that physical and 
      sexual abuse is highly predictive of adolescent suicidality, with variations by
      ethnic group. Currently, there is a disturbing lack of sufficient research on
      adolescent suicide in NYC, specifically regarding causal factors, the effects of 
      television on suicide, comorbid suicidality and drug abuse, and cultural factors 
      contributing to suicide. This dearth of literature may be related to the ethical 
      problems inherent in suicide research, self reports and/or post mortem analyses.
FAU - Ganz, Debora
AU  - Ganz D
AD  - Ferkauf Graduate School of Psychology of Yeshiva University, New York, NY, USA.
      drleosher@gmail.com
FAU - Sher, Leo
AU  - Sher L
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111129
PL  - Germany
TA  - Int J Adolesc Med Health
JT  - International journal of adolescent medicine and health
JID - 8506960
SB  - IM
MH  - Adolescent
MH  - *Adolescent Behavior/drug effects/psychology
MH  - Adolescent Health Services/statistics & numerical data
MH  - Child Abuse/*prevention & control/psychology
MH  - Comorbidity
MH  - Female
MH  - Humans
MH  - Longitudinal Studies/statistics & numerical data
MH  - Male
MH  - *Mental Disorders/complications/epidemiology/psychology
MH  - Mental Health Services/statistics & numerical data
MH  - Needs Assessment
MH  - New York City/epidemiology
MH  - Research
MH  - Risk Factors
MH  - Socioeconomic Factors
MH  - Substance-Related Disorders/*complications/psychology
MH  - *Suicide/prevention & control/psychology/statistics & numerical data
MH  - Television
EDAT- 2012/08/23 06:00
MHDA- 2012/10/19 06:00
CRDT- 2012/08/23 06:00
PHST- 2010/12/01 00:00 [received]
PHST- 2011/01/05 00:00 [accepted]
PHST- 2012/08/23 06:00 [entrez]
PHST- 2012/08/23 06:00 [pubmed]
PHST- 2012/10/19 06:00 [medline]
AID - 10.1515/ijamh.2012.015 [doi]
AID - /j/ijamh.2012.24.issue-2/ijamh.2012.015/ijamh.2012.015.xml [pii]
PST - ppublish
SO  - Int J Adolesc Med Health. 2012;24(2):99-104. doi: 10.1515/ijamh.2012.015. Epub
      2011 Nov 29.


PMID- 22863491
OWN - NLM
STAT- MEDLINE
DCOM- 20121231
LR  - 20120806
IS  - 1646-0758 (Electronic)
IS  - 0870-399X (Linking)
VI  - 24 Suppl 4
DP  - 2011 Dec
TI  - [Alcohol liver disease patients and liver transplantation: a psychosocial
      approach].
PG  - 835-44
AB  - One of the most common indications for Liver transplantation is Alcohol Liver
      Disease (ALD). Transplant recipients with ALD have a similar prognosis in terms
      of medical evolution and quality of life to those with other liver diseases. ALD 
      is present when alcoholism (alcohol dependence /abuse) or heavy drinking coexists
      with chronic/acute liver disease. In the present article difficulties in
      establishing this diagnosis are debated. The main predictors of alcohol intake
      relapse after transplantation are: pre-transplantation abstinence (> 6m), social 
      support, diagnosis acceptance, history of previous treatments, alcohol abuse VS
      dependence, Vaillant prognosis factors, good adherence (good prognosis); and
      family history of alcoholism, psychiatric history (psychosis, personality
      disorder), duration of alcoholism period, quantity of alcohol /day consumed (bad 
      prognosis). Based in these factors we present a new evaluation scale. Diagnosis
      of alcohol relapse depends on the criterion used. Relapse rate is 5.6% /year. In 
      the end of this article we discuss the different psychopharmacological and
      psychological methods used to treat pos-transplantation alcoholism relapse and
      some ethical aspects related to discrimination of patients with ALD.
FAU - Telles-Correia, Diogo
AU  - Telles-Correia D
AD  - Servico de Psiquiatria, Faculdade de Medicina de Lisboa, Unidade Transplantacao, 
      Hospital Curry Cabral, Lisboa, Portugal.
LA  - por
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Candidatos a transplante hepatico com doenca hepatica alcoolica: aspectos
      psicossociais.
DEP - 20111231
PL  - Portugal
TA  - Acta Med Port
JT  - Acta medica portuguesa
JID - 7906803
SB  - IM
MH  - Humans
MH  - Liver Diseases, Alcoholic/diagnosis/psychology/*surgery
MH  - *Liver Transplantation
MH  - Patient Selection
MH  - Recurrence
EDAT- 2012/08/17 06:00
MHDA- 2013/01/01 06:00
CRDT- 2012/08/07 06:00
PHST- 2012/08/07 06:00 [entrez]
PHST- 2012/08/17 06:00 [pubmed]
PHST- 2013/01/01 06:00 [medline]
PST - ppublish
SO  - Acta Med Port. 2011 Dec;24 Suppl 4:835-44. Epub 2011 Dec 31.


PMID- 22863486
OWN - NLM
STAT- MEDLINE
DCOM- 20121231
LR  - 20120806
IS  - 1646-0758 (Electronic)
IS  - 0870-399X (Linking)
VI  - 24 Suppl 4
DP  - 2011 Dec
TI  - [Abortion: legal, deontological and ethical framework].
PG  - 791-8
AB  - Pregnancy interruption before fetal viability limit is inherent to a
      multidisciplinary reflection, due to the conflicts involved. Portuguese laws have
      been altered along time in the way of women's health protection, allowing the
      needed information and support towards a free, informed and enlightened decision.
      Deontological determinants about health professionals towards abortion indicate
      the practice accordingly the law. Nevertheless, it is safeguarded their right to 
      consciousness objection. Ethical discussion about abortion, in its different
      ways, includes the concern about the value of intrauterine human life, and also
      the respect for individual autonomy. Even though the debate about intrauterine
      human life moral status is viewed from different theories and points of view, it 
      is concluded that different perspectives about this matter are acceptable, in an 
      interpersonal diversity valorization point of view.
FAU - Canario, Catarina
AU  - Canario C
AD  - Escola de Psicologia da Universidade do Minho, Braga, Portugal.
FAU - Figueiredo, Barbara
AU  - Figueiredo B
FAU - Ricou, Miguel
AU  - Ricou M
LA  - por
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Abortamento: enquadramento legal, deontologico e perspectiva etica.
DEP - 20111231
PL  - Portugal
TA  - Acta Med Port
JT  - Acta medica portuguesa
JID - 7906803
SB  - IM
MH  - Abortion, Induced/*ethics/*legislation & jurisprudence
MH  - Female
MH  - Humans
MH  - Portugal
MH  - Pregnancy
EDAT- 2012/08/17 06:00
MHDA- 2013/01/01 06:00
CRDT- 2012/08/07 06:00
PHST- 2012/08/07 06:00 [entrez]
PHST- 2012/08/17 06:00 [pubmed]
PHST- 2013/01/01 06:00 [medline]
PST - ppublish
SO  - Acta Med Port. 2011 Dec;24 Suppl 4:791-8. Epub 2011 Dec 31.


PMID- 22882504
OWN - NLM
STAT- MEDLINE
DCOM- 20121018
LR  - 20120813
IS  - 1440-1800 (Electronic)
IS  - 1320-7881 (Linking)
VI  - 19
IP  - 3
DP  - 2012 Sep
TI  - Unmasking the predicament of cultural voyeurism: a postcolonial analysis of
      international nursing placements.
PG  - 190-201
LID - 10.1111/j.1440-1800.2011.00555.x [doi]
AB  - The growing interest in international nursing placements cannot be left
      unnoticed. After 11 years into this twenty-first century, violations of human
      rights and freedom of speech, environmental disasters, and armed conflicts still 
      create dire living conditions for men and women around the world. Nurses have an 
      ethical duty to address issues of social justice and global health as a means to 
      fulfil nursing's social mandate. However, international placements raise some
      concerns. Drawing on the works of postcolonial theorists in nursing and social
      sciences, we examine the risk of replicating colonialist practices and discourses
      of health in international clinical placements. Referring to Bakhtin's notions of
      dialogism and unfinalizability, we envision a culturally safe nursing practice
      arising from dialogical encounters between the Self as an Other and with the
      Other as an Other. We suggest that exploring the intricacies of cultural and race
      relations in everyday nursing practice are the premises upon which nurses can
      understand the broader historic, racial, gendered, political and economic
      contexts of global health issues. Finally, we make suggestions for developing
      culturally safe learning opportunities at the international level without
      minimizing the impact of dialogical cultural encounters occurring at the local
      and community levels.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Racine, Louise
AU  - Racine L
AD  - University of Saskatchewan, College of Nursing, SK, Canada.
      louise.racine@usask.ca
FAU - Perron, Amelie
AU  - Perron A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110710
PL  - Australia
TA  - Nurs Inq
JT  - Nursing inquiry
JID - 9505881
MH  - Anthropology, Cultural
MH  - *Colonialism
MH  - Education, Nursing, Baccalaureate/*organization & administration
MH  - Feminism
MH  - Humans
MH  - *International Educational Exchange
MH  - Nursing Education Research
MH  - Nursing Theory
MH  - Terminology as Topic
MH  - Transcultural Nursing/*education
EDAT- 2012/08/14 06:00
MHDA- 2012/10/19 06:00
CRDT- 2012/08/14 06:00
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2012/10/19 06:00 [medline]
AID - 10.1111/j.1440-1800.2011.00555.x [doi]
PST - ppublish
SO  - Nurs Inq. 2012 Sep;19(3):190-201. doi: 10.1111/j.1440-1800.2011.00555.x. Epub
      2011 Jul 10.


PMID- 22851835
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130612
LR  - 20211021
IS  - 0972-2068 (Print)
IS  - 0973-9793 (Linking)
VI  - 73
IP  - 4
DP  - 2011 Aug
TI  - Randomised clinical trials in surgery: a look at the ethical and practical
      issues.
PG  - 245-50
LID - 10.1007/s12262-011-0307-5 [doi]
AB  - An ethically conducted randomised controlled trial (RCT) is the backbone of
      evidence based medicine. In surgical practice however, RCTs have taken a
      backseat, drawing much adverse comment. There are several reasons to explain
      surgeons' disinclination to conduct RCTs. These include many practical
      difficulties such as the problem of blinding surgical procedures, design and
      funding issues. There are also many ethical issues which need to be considered
      including the concept of equipoise as well as the ethical issues associated with 
      sham surgery as a control. While there is no doubt that RCTs are essential and in
      fact have helped to weed out several unnecessary surgical procedures, it is
      important not to lose sight of the fact that they may not be always necessary in 
      order to obtain evidence in favour of a procedure. Possible solutions could be to
      follow guidelines that have been issued by learned bodies and a strict adherence 
      to all ethical norms that have been recommended in the conduct of trials.
FAU - Das, Anjan Kumar
AU  - Das AK
AD  - Clinical Research Leader, Stempeutics Research Malaysia, Kuala Lumpur, Malaysia.
LA  - eng
PT  - Journal Article
DEP - 20110519
PL  - India
TA  - Indian J Surg
JT  - The Indian journal of surgery
JID - 0373026
PMC - PMC3144342
OTO - NOTNLM
OT  - Ethics
OT  - Evidence based medicine
OT  - Randomised controlled trials
EDAT- 2012/08/02 06:00
MHDA- 2012/08/02 06:01
CRDT- 2012/08/02 06:00
PHST- 2010/10/25 00:00 [received]
PHST- 2010/12/31 00:00 [accepted]
PHST- 2012/08/02 06:00 [entrez]
PHST- 2012/08/02 06:00 [pubmed]
PHST- 2012/08/02 06:01 [medline]
AID - 10.1007/s12262-011-0307-5 [doi]
AID - 307 [pii]
PST - ppublish
SO  - Indian J Surg. 2011 Aug;73(4):245-50. doi: 10.1007/s12262-011-0307-5. Epub 2011
      May 19.


PMID- 22844751
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20121214
IS  - 0001-4079 (Print)
IS  - 0001-4079 (Linking)
VI  - 195
IP  - 8
DP  - 2011 Nov
TI  - [Simulation in pediatric surgery].
PG  - 1913-20; discussion 1920-1
AB  - Simulation in paediatric surgery is essential for educational, ethical,
      medicolegal and economic reasons, and is particularly important for rare
      procedures. There are three different levels of simulation:--simulation of basic 
      techniques in order to learn or improve surgical skills (dissection,
      intracorporeal knots, etc.);--preparation for surgery using virtual reality, to
      perfect and test various procedures on a virtual patient, and to determine the
      best approaches for individual cases;--behavioral simulation underlines the
      importance of the preoperative check-list and facilitates crisis management
      (complications, conversion, etc.).
FAU - Becmeur, Francois
AU  - Becmeur F
AD  - Chirurgie pediatrique, Hopital de Hautepierre, 67098 Strasbourg cedex.
      Francois.Becmeur@chru-strasbourg.fr
FAU - Lacreuse, Isabelle
AU  - Lacreuse I
FAU - Soler, Luc
AU  - Soler L
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Simulation en chirurgie pediatrique.
PL  - Netherlands
TA  - Bull Acad Natl Med
JT  - Bulletin de l'Academie nationale de medecine
JID - 7503383
SB  - IM
MH  - Child
MH  - *Computer Simulation
MH  - *Computer-Assisted Instruction
MH  - General Surgery/*education
MH  - Humans
MH  - Laparoscopy/education
MH  - Surgical Procedures, Operative
EDAT- 2012/08/01 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/08/01 06:00
PHST- 2012/08/01 06:00 [entrez]
PHST- 2012/08/01 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
PST - ppublish
SO  - Bull Acad Natl Med. 2011 Nov;195(8):1913-20; discussion 1920-1.


PMID- 22816063
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 2150-7716 (Print)
IS  - 2150-7724 (Linking)
VI  - 2
IP  - 3
DP  - 2011 Jul
TI  - Physician-Researchers' Experiences of the Consent Process in the Sociocultural
      Context of a Developing Country.
PG  - 38-46
AB  - Background: International guidelines for medical research involving human
      subjects maintain the primacy of informed consent while recognizing cultural
      diversity. Methods: This article draws on empirical data obtained from interviews
      with physician-researchers in teaching hospitals of Lahore, Pakistan, to identify
      social and cultural factors that affect the consent process for participants in
      research. Results: This article presents variable findings with regards to
      communication, comprehension, and decision making. While some physicians consider
      that social factors such as lack of education, a patriarchal family system, and
      skepticism about research can make patients dependent on either the
      physician-researcher or the family, others believe that patients do make
      independent decisions. Conclusions: In light of the findings, the article ends
      with a recommendation for communication and decision making that is sensitive to 
      the local sociocultural environment while at the same time meeting the ethical
      imperative of respect for persons.
FAU - Malik, Aisha Y
AU  - Malik AY
AD  - University of Oxford.
LA  - eng
PT  - Journal Article
DEP - 20111011
PL  - United States
TA  - AJOB Prim Res
JT  - AJOB primary research
JID - 101520734
PMC - PMC3396358
EDAT- 2012/07/21 06:00
MHDA- 2012/07/21 06:01
CRDT- 2012/07/21 06:00
PHST- 2012/07/21 06:00 [entrez]
PHST- 2012/07/21 06:00 [pubmed]
PHST- 2012/07/21 06:01 [medline]
AID - 10.1080/21507716.2011.616183 [doi]
PST - ppublish
SO  - AJOB Prim Res. 2011 Jul;2(3):38-46. doi: 10.1080/21507716.2011.616183. Epub 2011 
      Oct 11.


PMID- 22813564
OWN - NLM
STAT- MEDLINE
DCOM- 20130425
LR  - 20171116
IS  - 1878-0334 (Electronic)
IS  - 1871-4021 (Linking)
VI  - 5
IP  - 3
DP  - 2011 Jul-Sep
TI  - PONI and its association with oxidative stress in type I and type II diabetes
      mellitus.
PG  - 126-9
LID - 10.1016/j.dsx.2012.02.022 [doi]
AB  - OBJECTIVE: Paraoxonase (PON) is an antioxidant enzyme linked with cardiovascular 
      disease (CVD), diabetes as it prevents LDL oxidation. The relation of PON with
      the other established risk factor of diabetic complications has not been looked
      into. RESEARCH DESIGN AND METHODS: 370 subjects were included in the study.
      Dividing into four group, i.e. group I included type II DM (n=220), group II was 
      age matched control (n=100), group III were type I DM (n=25) and group IV (n=25) 
      were age matched control group. The protocol of the study was approved by the
      ethical committee of the institute. SOD, GSH, PON (paraoxonase and arylesterase
      activity), GHb, and MDA were estimated. RESULTS: A highly significant decrease in
      paraoxonase and arylesterase activity was seen in the type II DM (p<0.0001) while
      in type I DM both the activity was not significant (p>0.05). Paraoxonase and
      arylesterase activity of PONI showed a negative significant correlated with MDA
      (r=-0.51, p<0.0001 and r=-0.23, p<0.001) in type II DM but was not correlated in 
      type I DM. The GHb and MDA levels were significantly increased (p<0.0001) while
      the levels of SOD and GSH have been decreased in type I and type II DM.
      CONCLUSION: PONI is definitely associated with development of the complications
      of diabetes. This may be due to the role of it as an antioxidant. As it also show
      a negative correlation with MDA like the other antioxidants studied.
CI  - Copyright (c) 2012 Diabetes India. Published by Elsevier Ltd. All rights
      reserved.
FAU - Nair, Sandhya Pillai
AU  - Nair SP
AD  - Dept of Biochemistry, S.B.K.S. Medical College and Research Institute, Vadodara, 
      Gujarat, India. meetsp3@yahoo.co.in
FAU - Shah, N C
AU  - Shah NC
FAU - Taggarsi, Anand
AU  - Taggarsi A
FAU - Nayak, Uma
AU  - Nayak U
LA  - eng
PT  - Journal Article
DEP - 20120329
PL  - Netherlands
TA  - Diabetes Metab Syndr
JT  - Diabetes & metabolic syndrome
JID - 101462250
RN  - 0 (Antioxidants)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 1.- (Oxidoreductases)
RN  - EC 3.1.8.1 (Aryldialkylphosphatase)
RN  - EC 3.1.8.1 (PON1 protein, human)
SB  - IM
MH  - Antioxidants/*physiology
MH  - Aryldialkylphosphatase/*metabolism
MH  - Child
MH  - Diabetes Mellitus, Type 1/*enzymology/pathology
MH  - Diabetes Mellitus, Type 2/*enzymology/pathology
MH  - Glycated Hemoglobin A/metabolism
MH  - Humans
MH  - Malondialdehyde/metabolism
MH  - Middle Aged
MH  - Oxidative Stress/*physiology
MH  - Oxidoreductases/metabolism
EDAT- 2012/07/21 06:00
MHDA- 2013/04/26 06:00
CRDT- 2012/07/21 06:00
PHST- 2012/07/21 06:00 [entrez]
PHST- 2012/07/21 06:00 [pubmed]
PHST- 2013/04/26 06:00 [medline]
AID - S1871-4021(12)00023-9 [pii]
AID - 10.1016/j.dsx.2012.02.022 [doi]
PST - ppublish
SO  - Diabetes Metab Syndr. 2011 Jul-Sep;5(3):126-9. doi: 10.1016/j.dsx.2012.02.022.
      Epub 2012 Mar 29.


PMID- 22812155
OWN - NLM
STAT- MEDLINE
DCOM- 20120814
LR  - 20220409
IS  - 0001-4079 (Print)
IS  - 0001-4079 (Linking)
VI  - 195
IP  - 7
DP  - 2011 Oct
TI  - [The doctor-patient relationship: new psychological models].
PG  - 1477-88; discussion 1488-90
AB  - The physician-patient relationship involves both ethical and psychological
      aspects. The notion of empathy has been extensively described, and this
      "asymmetric dialogue" has been shown capable of affecting patient behavior. The
      Internet, and particularly medical websites, are modifying the physician-patient 
      relationship by providing patients with knowledge of their disease, and are
      changing the social perception of medicine. More recent theories on medical
      relationships underline the importance of patience, tolerance and the ability to 
      accept opposition and disappointment.
FAU - Lejoyeux, Michel
AU  - Lejoyeux M
AD  - Hopitaux Bichat et Beaujon, 46, rue Henri Huchard, 75018 Paris.
      michel.lejoyeux@bch.ap-hop-paris.fr
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Contenus de la relation medecin-malade: place des modeles psychologiques.
PL  - Netherlands
TA  - Bull Acad Natl Med
JT  - Bulletin de l'Academie nationale de medecine
JID - 7503383
SB  - IM
MH  - Communication
MH  - Empathy
MH  - Ethics, Medical
MH  - Humans
MH  - *Physician-Patient Relations
EDAT- 2012/07/21 06:00
MHDA- 2012/08/15 06:00
CRDT- 2012/07/21 06:00
PHST- 2012/07/21 06:00 [entrez]
PHST- 2012/07/21 06:00 [pubmed]
PHST- 2012/08/15 06:00 [medline]
PST - ppublish
SO  - Bull Acad Natl Med. 2011 Oct;195(7):1477-88; discussion 1488-90.


PMID- 22810874
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20121109
IS  - 1080-2371 (Print)
IS  - 1080-2371 (Linking)
VI  - 17
IP  - 3 Neurorehabilitation
DP  - 2011 Jun
TI  - The limits of parental authority to accept or refuse medical treatment.
PG  - 641-3
LID - 10.1212/01.CON.0000399085.05007.02 [doi]
AB  - The legal and ethical right of parents to refuse medical treatment for their
      children differs from the authority possessed by competent adults with decisional
      capacity. Parents have a duty to act in the best interests of their children from
      the children's perspective and not to inflict harm. Best interests are determined
      by weighing benefits and burdens, which includes using evidence-based outcomes
      and value judgments. The result is placed along a risk/benefit spectrum. If the
      result is close to low risk/high benefit, the parents have a strong obligation to
      accept a health care team recommendation. Otherwise, parents may choose between
      reasonable medical options without threat or coercion.
FAU - Miller, Geoffrey
AU  - Miller G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Continuum (Minneap Minn)
JT  - Continuum (Minneapolis, Minn.)
JID - 9509333
EDAT- 2012/07/20 06:00
MHDA- 2012/07/20 06:01
CRDT- 2012/07/20 06:00
PHST- 2012/07/20 06:00 [entrez]
PHST- 2012/07/20 06:00 [pubmed]
PHST- 2012/07/20 06:01 [medline]
AID - 10.1212/01.CON.0000399085.05007.02 [doi]
AID - 00132979-201106000-00020 [pii]
PST - ppublish
SO  - Continuum (Minneap Minn). 2011 Jun;17(3 Neurorehabilitation):641-3. doi:
      10.1212/01.CON.0000399085.05007.02.


PMID- 22810034
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20121109
IS  - 1080-2371 (Print)
IS  - 1080-2371 (Linking)
VI  - 17
IP  - 6 2ndary Stroke Prevention
DP  - 2011 Dec
TI  - Emergency management of acute ischemic stroke in incapacitated patients who have 
      no surrogate decision makers.
PG  - 1335-9
LID - 10.1212/01.CON.0000410040.49724.24 [doi]
AB  - When hospitalized patients with acute ischemic stroke are unable to make their
      own medical decisions, clinicians usually turn to advance directives and the
      patient's close family members and friends to define the patient's wishes and
      expectations regarding treatment and prognosis. In many jurisdictions, if there
      is no surrogate for an incapacitated patient, an emergency ethics or risk
      management consultation is advisable and is usually done with a representative of
      the hospital's law office. The ethics team can represent the patient's interests 
      by hearing the recommendations of the treating physicians and then deciding
      whether their recommended treatment plan is ethically permissible and in the
      patient's interests. Depending on the jurisdiction, it is sometimes necessary for
      the courts to appoint a guardian for incapacitated patients who have no surrogate
      decision makers available.
FAU - Rincon, Fred
AU  - Rincon F
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Continuum (Minneap Minn)
JT  - Continuum (Minneapolis, Minn.)
JID - 9509333
EDAT- 2012/07/20 06:00
MHDA- 2012/07/20 06:01
CRDT- 2012/07/20 06:00
PHST- 2012/07/20 06:00 [entrez]
PHST- 2012/07/20 06:00 [pubmed]
PHST- 2012/07/20 06:01 [medline]
AID - 10.1212/01.CON.0000410040.49724.24 [doi]
AID - 00132979-201112000-00012 [pii]
PST - ppublish
SO  - Continuum (Minneap Minn). 2011 Dec;17(6 2ndary Stroke Prevention):1335-9. doi:
      10.1212/01.CON.0000410040.49724.24.


PMID- 22809985
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20121109
IS  - 1080-2371 (Print)
IS  - 1080-2371 (Linking)
VI  - 17
IP  - 5 Neurologic Consultation in the Hospital
DP  - 2011 Oct
TI  - When physicians disagree: a case of nonconvulsive status epilepticus.
PG  - 1119-23
LID - 10.1212/01.CON.0000407064.27070.d6 [doi]
AB  - Differences of opinion among attending physicians, resident trainees, and nurses 
      are not uncommon in hospital situations. When such cases arise, ethical dilemmas 
      must be approached with mindfulness of basic ethics principles and communication.
      This article presents a case of nonconvulsive status epilepticus to highlight
      these considerations.
FAU - Hixson, John David
AU  - Hixson JD
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Continuum (Minneap Minn)
JT  - Continuum (Minneapolis, Minn.)
JID - 9509333
EDAT- 2012/07/20 06:00
MHDA- 2012/07/20 06:01
CRDT- 2012/07/20 06:00
PHST- 2012/07/20 06:00 [entrez]
PHST- 2012/07/20 06:00 [pubmed]
PHST- 2012/07/20 06:01 [medline]
AID - 10.1212/01.CON.0000407064.27070.d6 [doi]
AID - 00132979-201110000-00012 [pii]
PST - ppublish
SO  - Continuum (Minneap Minn). 2011 Oct;17(5 Neurologic Consultation in the
      Hospital):1119-23. doi: 10.1212/01.CON.0000407064.27070.d6.


PMID- 22783693
OWN - NLM
STAT- MEDLINE
DCOM- 20120809
LR  - 20151119
IS  - 0309-3913 (Print)
IS  - 0309-3913 (Linking)
VI  - 40
IP  - 4
DP  - 2011 Dec
TI  - Ocular status of commercial drivers in Osun State, Nigeria.
PG  - 405-11
AB  - AIMS/OBJECTIVES: To determine the ocular status of commercial vehicle drivers in 
      Osun State, Western Nigeria and highlight the effect on safety on the road.
      DESIGN: A cross-sectional-survey utilizing a multistage-random-sampling-technique
      done between May and June 2004. PARTICIPANTS: 99 consenting commercial vehicle
      drivers, registered with NURTW, Osogbo. Motorcyclists and non-registered NURTW
      drivers were excluded. METHODS: Clearance from LAUTECH Teaching Hospital's (LTH) 
      ethical committee and informed consent obtained. Structured questionnaire and
      complete eye examination with vision test was done in the clinic. Driving test
      and ability to read number plates from a distance of 20.5m before and after
      dilatation were done in the hospital premises. RESULTS: Mean age of the subjects 
      was 45.9 years (SD 7.7). Prevalence of visual impairment was 6.1%.and of failed
      driving test was 6.1%, while, uniocular blindness was 5.1%. Pupillary dilatation 
      significantly reduced both ability to drive and to read number plate p < 0.05.
      Road traffic accident was associated with visual impairement, field loss, protan 
      colour deficiency, cup:disc ratio > 0.5, and intraocular pressure > 21 mmHg. RTA 
      was less likely among those who could read number plates (OR = 0.51). Prevalence 
      of cataract was 24.3%, pterygia 20.7%, cornea opacity 6.6% and
      uncorrected-refractive errors 31.3%, with hypermetropia being most prevalent
      (19.7%). None had corrective lenses as at time of examination. CONCLUSION: Eye
      diseases causing uniocular blindness, visual impairment and uncorrected
      refractive errors were seen to be common among the commercial vehicle drivers.
      Mandatory, specific-periodic ophthalmological examination for correcting and
      preventing these are necessary before first issuance and revalidation of driver's
      license. Health education about eye care is therefore necessary to enhance safety
      on our roads.
FAU - Isawumi, M A
AU  - Isawumi MA
AD  - Department of Ophthalmology, Ladoke Akintola University Teaching Hospital,
      Osogbo, Osun State, Nigeria. misawumi@gmail.com
FAU - Adeoti, C O
AU  - Adeoti CO
FAU - Ubah, J N
AU  - Ubah JN
FAU - Oluwatimilehin, I O
AU  - Oluwatimilehin IO
FAU - Raji, R A
AU  - Raji RA
LA  - eng
PT  - Journal Article
PL  - Nigeria
TA  - Afr J Med Med Sci
JT  - African journal of medicine and medical sciences
JID - 7801013
SB  - IM
MH  - Adult
MH  - *Automobile Driving
MH  - Cross-Sectional Studies
MH  - Eye Diseases/*epidemiology/etiology
MH  - Female
MH  - Health Surveys
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nigeria/epidemiology
MH  - Prevalence
MH  - Surveys and Questionnaires
MH  - Transportation
MH  - Vision Disorders/*epidemiology/etiology
MH  - Vision Tests
MH  - *Vision, Ocular
MH  - Visual Acuity
MH  - Young Adult
EDAT- 2012/07/13 06:00
MHDA- 2012/08/10 06:00
CRDT- 2012/07/13 06:00
PHST- 2012/07/13 06:00 [entrez]
PHST- 2012/07/13 06:00 [pubmed]
PHST- 2012/08/10 06:00 [medline]
PST - ppublish
SO  - Afr J Med Med Sci. 2011 Dec;40(4):405-11.


PMID- 22764830
OWN - NLM
STAT- MEDLINE
DCOM- 20121119
LR  - 20131121
IS  - 1399-3046 (Electronic)
IS  - 1397-3142 (Linking)
VI  - 16
IP  - 5
DP  - 2012 Aug
TI  - Oseltamivir-resistant 2009 H1N1 influenza pneumonia during therapy in a renal
      transplant recipient.
PG  - E153-7
LID - 10.1111/j.1399-3046.2011.01489.x [doi]
AB  - The emergence of oseltamivir-resistant 2009 H1N1 influenza virus (conferred by
      the H275Y substitution in NA) during therapy or prophylaxis in immunocompromised 
      patients is a serious concern. The optimal therapy for immunosuppressed patients 
      with oseltamivir-resistant 2009 H1N1 influenza virus is unknown and few options
      exist. We report a 10-yr-old recipient of kidney transplant who was hospitalized 
      with oseltamivir-resistant 2009 H1N1 influenza pneumonia complicated by severe
      respiratory failure, ARDS, and renal failure requiring institution of ECMO and
      CRRT. On presentation, treatment with oseltamivir (second course) and
      broad-spectrum antibiotics was initiated. Immunosuppressive agents were stopped
      on hospital day (d) 2. On hospital d 7, given his critical status,
      immunocompromised state, and difficulty in obtaining intravenous zanamivir, after
      obtaining ethical approval and parental consent, he was treated with intravenous 
      peramivir (through an Emergency Investigational New Drug Application) for two wk.
      He tolerated the regimen well and his clinical status improved gradually. Several
      factors may have contributed to virus clearance and survival including recovery
      of the immune system, aggressive critical care support, and administration of
      peramivir. Ongoing surveillance is essential to monitor how oseltamivir-resistant
      H275Y mutant viruses may evolve in the future.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Shetty, Avinash K
AU  - Shetty AK
AD  - Department of Surgery, Wake Forest University School of Medicine and Brenner
      Children's Hospital, Winston Salem, NC, USA. ashetty@wfubmc.edu
FAU - Ross, Gregory A
AU  - Ross GA
FAU - Pranikoff, Thomas
AU  - Pranikoff T
FAU - Gubareva, Larissa V
AU  - Gubareva LV
FAU - Sechrist, Catherine
AU  - Sechrist C
FAU - Guirand, Derek M
AU  - Guirand DM
FAU - Abramson, Jon
AU  - Abramson J
FAU - Lin, Jen-Jar
AU  - Lin JJ
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20110309
PL  - Denmark
TA  - Pediatr Transplant
JT  - Pediatric transplantation
JID - 9802574
RN  - 0 (Antiviral Agents)
RN  - 20O93L6F9H (Oseltamivir)
SB  - IM
MH  - Antiviral Agents/pharmacology/*therapeutic use
MH  - Child
MH  - *Drug Resistance, Viral
MH  - Humans
MH  - Immunocompromised Host
MH  - Influenza A Virus, H1N1 Subtype/*drug effects/isolation & purification
MH  - Influenza, Human/diagnosis/drug therapy/*immunology/virology
MH  - Kidney Transplantation
MH  - Male
MH  - Oseltamivir/pharmacology/*therapeutic use
MH  - Pneumonia, Viral/diagnosis/drug therapy/*immunology/virology
MH  - Postoperative Complications/diagnosis/drug therapy/*immunology/virology
EDAT- 2012/07/07 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/07 06:00
PHST- 2012/07/07 06:00 [entrez]
PHST- 2012/07/07 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1111/j.1399-3046.2011.01489.x [doi]
PST - ppublish
SO  - Pediatr Transplant. 2012 Aug;16(5):E153-7. doi: 10.1111/j.1399-3046.2011.01489.x.
      Epub 2011 Mar 9.


PMID- 22724045
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1939-2389 (Print)
IS  - 1939-2389 (Linking)
VI  - 5
IP  - 1
DP  - 2011 Fall
TI  - The Global Governance of Bioethics: Negotiating UNESCO's Universal Declaration on
      Bioethics and Human Rights (2005).
PG  - 1-23
AB  - UNESCO's Universal Declaration on Bioethics and Human Rights (2005) was drawn up 
      by an independent panel of experts (the International Bioethics Committee) and
      negotiated by member states. UNESCO aimed for a participatory and transparent
      drafting process, holding national and regional consultations and seeking the
      views of various interest groups, including religious and spiritual ones.
      Furthermore, reflecting UNESCO's broad interpretation of bioethics, the IBC
      included medics, scientists, lawyers and philosophers among its membership.
      Nevertheless, several potential stakeholders-academic scientists and ethicists,
      government policy-makers and NGO representatives-felt they had not been
      sufficiently consulted or even represented during the Declaration's development. 
      Better communications and understanding within and between national, regional and
      international layers of governance would help to avoid a recurrence of this
      problem in future negotiations.
FAU - Langlois, Adele
AU  - Langlois A
AD  - Adele Langlois is a lecturer in the School of Social Sciences at the University
      of Lincoln in the United Kingdom.
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - 075315/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PL  - United States
TA  - Glob Health Gov
JT  - Global health governance : the scholarly journal for the new health security
      paradigm
JID - 101318458
PMC - PMC3378037
MID - UKMS47504
EDAT- 2012/06/23 06:00
MHDA- 2012/06/23 06:01
CRDT- 2012/06/23 06:00
PHST- 2012/06/23 06:00 [entrez]
PHST- 2012/06/23 06:00 [pubmed]
PHST- 2012/06/23 06:01 [medline]
PST - ppublish
SO  - Glob Health Gov. 2011 Fall;5(1):1-23.


PMID- 22719799
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1876-4533 (Print)
IS  - 1876-4533 (Linking)
VI  - 3
IP  - 3
DP  - 2012 Jun
TI  - The Diversity of Responsibility: The Value of Explication and Pluralization.
PG  - 131-145
AB  - PURPOSE: Although the term "responsibility" plays a central role in bioethics and
      public health, its meaning and implications are often unclear. This paper defends
      the importance of a more systematic conception of responsibility to improve moral
      philosophical as well as descriptive analysis. METHODS: We start with a formal
      analysis of the relational conception of responsibility and its meta-ethical
      presuppositions. In a brief historical overview, we compare global-collective,
      professional, personal, and social responsibility. The value of our analytical
      matrix is illustrated by sorting out the plurality of responsibility models in
      three cases (organ transplantation, advance directives, and genetic testing).
      RESULTS: Responsibility is a relational term involving at least seven relata. The
      analysis of the relata allows distinguishing between individual versus collective
      agency, retrospective versus prospective direction, and liability versus power
      relations. Various bioethical ambiguities result from insufficient, implicit, or 
      inappropriate ascriptions of responsibility. CONCLUSIONS: A systematic conception
      of responsibility is an important tool for bioethical reflection. It allows an
      in-depth understanding and critique of moral claims on a meta-ethical level
      without presuming one particular normative approach. Considering the concept of
      responsibility can also help to complement the current bioethical focus on
      individual autonomy by including the perspectives of other actors, such as family
      members or social groups.
FAU - Schicktanz, Silke
AU  - Schicktanz S
AD  - Department of Medical Ethics and History of Medicine, University Medical Center
      Gottingen, Humboldtallee 36, 37073 Gottingen, Germany.
FAU - Schweda, Mark
AU  - Schweda M
LA  - eng
PT  - Journal Article
DEP - 20111206
PL  - Netherlands
TA  - Med Stud
JT  - Medicine studies
JID - 101484005
PMC - PMC3375421
EDAT- 2012/06/22 06:00
MHDA- 2012/06/22 06:01
CRDT- 2012/06/22 06:00
PHST- 2011/08/15 00:00 [received]
PHST- 2011/10/20 00:00 [accepted]
PHST- 2012/06/22 06:00 [entrez]
PHST- 2012/06/22 06:00 [pubmed]
PHST- 2012/06/22 06:01 [medline]
AID - 10.1007/s12376-011-0070-8 [doi]
AID - 70 [pii]
PST - ppublish
SO  - Med Stud. 2012 Jun;3(3):131-145. doi: 10.1007/s12376-011-0070-8. Epub 2011 Dec 6.


PMID- 22715683
OWN - NLM
STAT- MEDLINE
DCOM- 20120719
LR  - 20120621
IS  - 0324-8267 (Print)
IS  - 0324-8267 (Linking)
VI  - 61
IP  - 4
DP  - 2011 Oct-Dec
TI  - [Diagnostic medical error as an overinterpretation of toxicology screening
      combined with inadequate clinical assessment].
PG  - 377-82
AB  - Problems of patient safety within the system of health care are defined by
      prescriptive and ethical regulations; a breach of such regulations is associated 
      with entering a complex category of situations covered by the term "medical
      error" or "appropriateness of medical management". In order to minimize the
      sources of diagnostic errors, with the knowledge on such errors largely
      originating from medico-legal practice, numerous initiatives emerge, according to
      which monitoring of adverse events and subjecting such events to a profound
      discussion is the most important element of prevention. The problem discussed in 
      the paper is illustrated by the case of a 13-year old boy, in whom opioid
      poisoning was mistakenly diagnosed instead of a neurological condition in
      consequence of the physician disregarding significant symptoms of the disease and
      accepting his subjective suspicion of poisoning. The erroneous diagnosis was
      further compounded by lack of verification of the preliminary diagnosis and
      failure to perform further laboratory diagnostic management addressing the
      neurological status of the patient. The presented case supports data from
      publications found in the literature on the subject that describe a high risk of 
      diagnostics errors in neurological conditions; such errors are often committed by
      emergency physicians other than neurologists.
FAU - Klys, Malgorzata
AU  - Klys M
AD  - Z Katedry Medycyny Sadowej UJ CM.
FAU - Kowalski, Piotr
AU  - Kowalski P
LA  - pol
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - Blad diagnostyczny jako nadinterpretacja przesiewowego badania toksykologicznego 
      przy niedostatecznej ocenie klinicznej.
PL  - Poland
TA  - Arch Med Sadowej Kryminol
JT  - Archiwum medycyny sadowej i kryminologii
JID - 1260766
RN  - 0 (Analgesics, Opioid)
SB  - IM
MH  - Adolescent
MH  - Analgesics, Opioid/*poisoning
MH  - Diagnosis, Differential
MH  - *Diagnostic Errors
MH  - Encephalitis/complications/*diagnosis
MH  - Humans
MH  - Male
MH  - Opioid-Related Disorders/diagnosis
MH  - Poisoning/*diagnosis
MH  - Stroke/*diagnosis/etiology
EDAT- 2012/06/22 06:00
MHDA- 2012/07/20 06:00
CRDT- 2012/06/22 06:00
PHST- 2012/06/22 06:00 [entrez]
PHST- 2012/06/22 06:00 [pubmed]
PHST- 2012/07/20 06:00 [medline]
PST - ppublish
SO  - Arch Med Sadowej Kryminol. 2011 Oct-Dec;61(4):377-82.


PMID- 22713193
OWN - NLM
STAT- MEDLINE
DCOM- 20121126
LR  - 20120620
IS  - 1646-0758 (Electronic)
IS  - 0870-399X (Linking)
VI  - 24
IP  - 6
DP  - 2011 Nov-Dec
TI  - [Preimplantation genetic diagnosis: technical and ethical considerations].
PG  - 987-96
AB  - Following the advances in the techniques of medically assisted reproduction
      (ART), 1990 has seen the first born child after the development of
      pre-implantation genetic diagnosis. In this analysis embryos are tested for the
      presence of genetic anomalies at three to five days after fertilization and only 
      unaffected embryos are transferred to the maternal uterus. The technique offers
      good prospects to couples at risk for conventional prenatal diagnosis. It is
      particularly useful where ART techniques are necessary, in which early embryo
      selection avoids later termination of pregnancy. In Portugal the application of
      laws concerning regulation of medically assisted reproduction in 2008 has
      clarified and formalised the medical and laboratory procedures and in some cases 
      fundamentally changed them, particularly in the requirement to cryopreserve all
      high quality non-transferred embryos and in specifying conditions in which embryo
      experimentation may be permitted.
FAU - Oliva Teles, Natalia
AU  - Oliva Teles N
AD  - Servico de Bioetica e Etica Medica, Faculdade de Medicina da Universidade do
      Porto, Centro de Genetica Jacinto Magalhaes, INSA, I.P. Porto, Portugal.
LA  - por
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Diagnostico genetico pre-implantacao: aspetos tecnicos e consideracoes eticas.
DEP - 20120220
PL  - Portugal
TA  - Acta Med Port
JT  - Acta medica portuguesa
JID - 7906803
SB  - IM
MH  - Humans
MH  - Preimplantation Diagnosis/*ethics/*methods
EDAT- 2012/06/21 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/06/21 06:00
PHST- 2010/08/18 00:00 [received]
PHST- 2011/05/26 00:00 [accepted]
PHST- 2012/06/21 06:00 [entrez]
PHST- 2012/06/21 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
PST - ppublish
SO  - Acta Med Port. 2011 Nov-Dec;24(6):987-96. Epub 2012 Feb 20.


PMID- 22685928
OWN - NLM
STAT- MEDLINE
DCOM- 20120626
LR  - 20120612
IS  - 0019-6568 (Print)
IS  - 0019-6568 (Linking)
VI  - 90
IP  - 3
DP  - 2011 Fall
TI  - Economic downturn may place dentists in ethical dilemma.
PG  - 18-9
FAU - Kerns, Keith
AU  - Kerns K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Indiana Dent Assoc
JT  - Journal (Indiana Dental Association)
JID - 8502537
MH  - Continuity of Patient Care/*legislation & jurisprudence
MH  - Dentist-Patient Relations/*ethics
MH  - *Economic Recession
MH  - *Ethics, Dental
MH  - Humans
MH  - Indiana
MH  - Liability, Legal
MH  - *Treatment Refusal
EDAT- 2012/06/13 06:00
MHDA- 2012/06/27 06:00
CRDT- 2012/06/13 06:00
PHST- 2012/06/13 06:00 [entrez]
PHST- 2012/06/13 06:00 [pubmed]
PHST- 2012/06/27 06:00 [medline]
PST - ppublish
SO  - J Indiana Dent Assoc. 2011 Fall;90(3):18-9.


PMID- 22685924
OWN - NLM
STAT- MEDLINE
DCOM- 20120626
LR  - 20120612
IS  - 0019-6568 (Print)
IS  - 0019-6568 (Linking)
VI  - 90
IP  - 3
DP  - 2011 Fall
TI  - Ethical soup: The need for a team approach to ethics of dentists, dental teams,
      patients and vendors.
PG  - 6-7
FAU - Dziwlik, Jay
AU  - Dziwlik J
AD  - Indiana Dental Association, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Indiana Dent Assoc
JT  - Journal (Indiana Dental Association)
JID - 8502537
MH  - Dental Staff/ethics
MH  - *Ethics, Dental
MH  - Humans
MH  - Societies, Dental
EDAT- 2012/06/13 06:00
MHDA- 2012/06/27 06:00
CRDT- 2012/06/13 06:00
PHST- 2012/06/13 06:00 [entrez]
PHST- 2012/06/13 06:00 [pubmed]
PHST- 2012/06/27 06:00 [medline]
PST - ppublish
SO  - J Indiana Dent Assoc. 2011 Fall;90(3):6-7.


PMID- 22669827
OWN - NLM
STAT- MEDLINE
DCOM- 20140422
LR  - 20120606
IS  - 0189-160X (Print)
IS  - 0189-160X (Linking)
VI  - 30
IP  - 4
DP  - 2011 Jul-Aug
TI  - Unsafe abortion and its ethical, sexual and reproductive rights implications.
PG  - 245-9
AB  - BACKGROUND: Unsafe abortion is an important cause of maternal mortality and
      morbidity, particularly marked in developing countries with restrictive abortion 
      laws. It has both bioethical and human rights implications, violating their key
      principles and components. OBJECTIVE: To highlight the magnitude of complications
      of unsafe abortion and examine the legal,bioethical, sexual and reproductive
      right implications of unsafe abortion as well as to review post abortion care
      (PAC) in Nigeria. DATA SOURCE: Information derived from online web-search,
      literature review of articles from learned journals, serials and monographs from 
      local and supra-national agencies working on abortion, and reproductive health.
      RESULTS: About 20 million unsafe abortions are performed annually globally
      resulting in about 80, 000 maternal deaths. Asia and Africa have the highest
      number of maternal deaths. In Nigeria, 760, 000 abortions are performed annually.
      Abortion law in Nigeria is restrictive. Unsafe abortion violates three key
      bioethical principles at micro and mega-ethical levels. It also violates eleven
      of the twelve components of sexual and reproductive rights. PAC is approved as an
      effective approach to reducing abortion morbidity and mortality and promoting
      women's reproductive rights. CONCLUSION: Stakeholders can promote the ethical,
      sexual and reproductive rights of women through the following interventions:
      advocacy, liberalization of restrictive abortion law, training of health workers 
      on PAC services, inter-organisational collaboration, development of right based
      code of ethics and inclusion into medical training curriculum. Socio-economic
      empowerment of women, provision of PAC services equipments in health facilities, 
      and improvement of access to quality family planning services will also help
      promote the rights of women.
FAU - Adinma, E
AU  - Adinma E
AD  - Department of Community Medicine, Nnamdi Azikiwe University Teaching Hospital,
      P.M.B. 5025, Nnewi, Anambra State, Nigeria. Email: drechenduadinma@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Nigeria
TA  - West Afr J Med
JT  - West African journal of medicine
JID - 8301891
SB  - IM
MH  - Abortion, Induced/*legislation & jurisprudence/mortality
MH  - *Developing Countries
MH  - Family Planning Services
MH  - Female
MH  - Humans
MH  - Maternal Mortality/trends
MH  - Nigeria/epidemiology
MH  - Pregnancy
MH  - *Reproductive Rights
MH  - Socioeconomic Factors
MH  - Survival Rate
EDAT- 2012/06/07 06:00
MHDA- 2014/04/23 06:00
CRDT- 2012/06/07 06:00
PHST- 2012/06/07 06:00 [entrez]
PHST- 2012/06/07 06:00 [pubmed]
PHST- 2014/04/23 06:00 [medline]
PST - ppublish
SO  - West Afr J Med. 2011 Jul-Aug;30(4):245-9.


PMID- 22664607
OWN - NLM
STAT- MEDLINE
DCOM- 20121029
LR  - 20190911
IS  - 1984-0446 (Electronic)
IS  - 0034-7167 (Linking)
VI  - 64
IP  - 6
DP  - 2011 Nov-Dec
TI  - [Characterization of the assistance of a hematology unit].
PG  - 1082-6
LID - S0034-71672011000600014 [pii]
AB  - This study aimed to describe the characteristics of service in a Hemotherapy Unit
      in the interior of the state of Sao Paulo in 2009. All ethical guidelines were
      followed and a survey was carried out in the database of the Unit. During the
      observed period, the Unit shows greater rate of repetition donors, with low
      levels of adverse reactions and 100% of donors' satisfaction. The units of
      clinical medicine and intensive therapy were the sectors with highest consumption
      of transfusions at the hospital service. The described unit is self-sufficient at
      managing its resources. The present study shows the need to explore the
      dimensions of the professional roles in hemotherapy, the possibilities of finding
      new donors, the reasons that lead patients to donate blood, characteristics,
      epidemiological profile and satisfaction of receptors.
FAU - Almeida, Rodrigo Guimaraes dos Santos
AU  - Almeida RG
AD  - Unidade Hemoterapica de Batatais, Batatais-SP, Brasil.
FAU - Mazzo, Alessandra
AU  - Mazzo A
FAU - Mendes, Isabel Amelia Costa
AU  - Mendes IA
FAU - Trevizan, Maria Auxiliadora
AU  - Trevizan MA
FAU - de Godoy, Simone
AU  - de Godoy S
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Caracterizacao do atendimento de uma Unidade de Hemoterapia.
PL  - Brazil
TA  - Rev Bras Enferm
JT  - Revista brasileira de enfermagem
JID - 7910105
MH  - Blood Donors/*statistics & numerical data
MH  - Brazil
MH  - *Hematology
MH  - *Hospital Units
MH  - Humans
MH  - *Quality of Health Care
EDAT- 2012/06/06 06:00
MHDA- 2012/10/30 06:00
CRDT- 2012/06/06 06:00
PHST- 2010/09/24 00:00 [received]
PHST- 2012/01/27 00:00 [accepted]
PHST- 2012/06/06 06:00 [entrez]
PHST- 2012/06/06 06:00 [pubmed]
PHST- 2012/10/30 06:00 [medline]
AID - S0034-71672011000600014 [pii]
AID - 10.1590/s0034-71672011000600014 [doi]
PST - ppublish
SO  - Rev Bras Enferm. 2011 Nov-Dec;64(6):1082-6. doi: 10.1590/s0034-71672011000600014.


PMID- 22664605
OWN - NLM
STAT- MEDLINE
DCOM- 20121029
LR  - 20190911
IS  - 1984-0446 (Electronic)
IS  - 0034-7167 (Linking)
VI  - 64
IP  - 6
DP  - 2011 Nov-Dec
TI  - [The nurse interacting and relating: the context of nursing care in a
      semi-intensive unit].
PG  - 1067-74
LID - S0034-71672011000600012 [pii]
AB  - This study aimed to understand the meaning of nursing care to nurses in the
      hospital. This is a qualitative research, based on theoretical and methodological
      assumptions of symbolic interaction. It was performed in a semi-intensive unit of
      a tertiary public hospital in Fortaleza-CE, Brazil. Eleven nurses participated on
      it. For data collection, it was used semi-structured interviews and field
      observation simple and, in data processing it was performed thematic category.
      The ethical aspects have been respected. It was observed that the nursing care
      means the establishment of the nurse's interpersonal relationships with other
      health professionals, patients and their accompanying persons. It was understood 
      that, for nurses of the hospital, nursing care means social interaction with
      people.
FAU - Lima, Marcos Paulo de Oliveira
AU  - Lima MP
FAU - de Freitas, Consuelo Helena Aires
AU  - de Freitas CH
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - A enfermeira interagindo e se relacionando: o contexto do cuidado de enfermagem
      em unidade semi-intensiva.
PL  - Brazil
TA  - Rev Bras Enferm
JT  - Revista brasileira de enfermagem
JID - 7910105
MH  - Humans
MH  - *Intensive Care Units
MH  - *Nurse-Patient Relations
MH  - *Nursing Service, Hospital
EDAT- 2012/06/06 06:00
MHDA- 2012/10/30 06:00
CRDT- 2012/06/06 06:00
PHST- 2010/10/10 00:00 [received]
PHST- 2012/01/04 00:00 [accepted]
PHST- 2012/06/06 06:00 [entrez]
PHST- 2012/06/06 06:00 [pubmed]
PHST- 2012/10/30 06:00 [medline]
AID - S0034-71672011000600012 [pii]
AID - 10.1590/s0034-71672011000600012 [doi]
PST - ppublish
SO  - Rev Bras Enferm. 2011 Nov-Dec;64(6):1067-74. doi:
      10.1590/s0034-71672011000600012.


PMID- 22654132
OWN - NLM
STAT- MEDLINE
DCOM- 20120726
LR  - 20211021
IS  - 0008-5286 (Print)
IS  - 0008-5286 (Linking)
VI  - 52
IP  - 12
DP  - 2011 Dec
TI  - An ethicist's commentary on racehorse abuse.
PG  - 1284
FAU - Rollin, Bernard E
AU  - Rollin BE
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Vet J
JT  - The Canadian veterinary journal = La revue veterinaire canadienne
JID - 0004653
SB  - IM
CIN - Can Vet J. 2012 May;53(5):457. PMID: 23115357
MH  - Animal Welfare/*ethics
MH  - Animals
MH  - Canada
MH  - Horses/*injuries
MH  - Sports/*ethics
MH  - Veterinarians/*ethics/*standards
PMC - PMC3215459
EDAT- 2012/06/02 06:00
MHDA- 2012/07/27 06:00
CRDT- 2012/06/02 06:00
PHST- 2012/06/02 06:00 [entrez]
PHST- 2012/06/02 06:00 [pubmed]
PHST- 2012/07/27 06:00 [medline]
PST - ppublish
SO  - Can Vet J. 2011 Dec;52(12):1284.


PMID- 22639501
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20220409
IS  - 2229-3418 (Electronic)
IS  - 0975-5950 (Linking)
VI  - 2
IP  - 2
DP  - 2011 Jul
TI  - A questionnaire survey on postoperative intermaxillary fixation in mandibular
      trauma: Is its use based on evidence?
PG  - 141-6
LID - 10.4103/0975-5950.94468 [doi]
AB  - CONTEXT: This questionnaire survey was conducted to ascertain if the practice of 
      the routine use of postoperative intermaxillary fixation (IMF) in mandibular
      trauma (of the dentate segments only) was based on evidence available in the
      literature. SETTINGS AND DESIGN: This study was designed as a questionnaire
      survey that would be conducted among surgeons operating on mandibular fractures
      in the state of Gujarat. MATERIALS AND METHODS: A typed questionnaire was sent to
      oral maxillofacial surgeons and plastic surgeons of Gujarat state for their
      feedback by post. Approval of the ethical committee of the university was
      obtained. All the feedback forms received back were included for this survey
      which included 25 oral and maxillofacial surgeons and 25 plastic surgeons.
      RESULTS: Although majority of the surgeons use open reduction and internal
      fixation (ORIF), 25% of the surgeons still prefer using only IMF as the sole
      modality of treatment for the said group of mandibular fractures. According to
      our survey, the majority of surgeons use IMF routinely in the postoperative
      setting even after using ORIF. Occlusion seems to be the critical factor among
      72% of surgeons in deciding on the use of IMF as an adjunct after ORIF.
      Seventy-eight percent of surgeons vary their period of IMF based on the site of
      fracture. CONCLUSION: The routine use of postoperative IMF in cases of mandibular
      fractures seems to find favor among surgeons despite lack of sound scientific
      evidence supporting its use. There is also no evidence to suggest that if IMF is 
      not used, it would have deleterious effects on occlusion or otherwise.
FAU - Shenoy, Nithin A
AU  - Shenoy NA
AD  - Department of Oral and Maxillofacial Surgery, K. M. Shah Dental College and
      Hospital, Vadodara, India.
FAU - Shah, Navin
AU  - Shah N
FAU - Shah, Jay
AU  - Shah J
LA  - eng
PT  - Journal Article
PL  - India
TA  - Natl J Maxillofac Surg
JT  - National journal of maxillofacial surgery
JID - 101578767
PMC - PMC3343413
OTO - NOTNLM
OT  - Immediate mobilization
OT  - mandibular trauma
OT  - postoperative intermaxillary fixation
EDAT- 2012/05/29 06:00
MHDA- 2012/05/29 06:01
CRDT- 2012/05/29 06:00
PHST- 2012/05/29 06:00 [entrez]
PHST- 2012/05/29 06:00 [pubmed]
PHST- 2012/05/29 06:01 [medline]
AID - 10.4103/0975-5950.94468 [doi]
AID - NJMS-2-141 [pii]
PST - ppublish
SO  - Natl J Maxillofac Surg. 2011 Jul;2(2):141-6. doi: 10.4103/0975-5950.94468.


PMID- 22611990
OWN - NLM
STAT- MEDLINE
DCOM- 20120807
LR  - 20161020
IS  - 0869-866X (Print)
IS  - 0869-866X (Linking)
IP  - 6
DP  - 2011 Nov-Dec
TI  - [The ethical and legal aspects of professional activities of
      obstetrician-gynecologist].
PG  - 42-3
AB  - The article demonstrates that both highly developed bioethical consciousness and 
      legal awareness and high level of bioethical and legal culture among
      obstetrician-gynecologists are important factors of enhancement of medical care
      quality. This postulate is discussed on the example of issues related to the
      induced abortion. The approaches to this issues applied in various countries are 
      considered.
FAU - Shmelev, I A
AU  - Shmelev IA
FAU - Mysiakov, V B
AU  - Mysiakov VB
LA  - rus
PT  - English Abstract
PT  - Journal Article
PL  - Russia (Federation)
TA  - Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med
JT  - Problemy sotsial'noi gigieny, zdravookhraneniia i istorii meditsiny
JID - 101270373
SB  - IM
MH  - Abortion, Induced/ethics/legislation & jurisprudence
MH  - Female
MH  - Gynecology/*ethics/*legislation & jurisprudence
MH  - Humans
MH  - Obstetrics/*ethics/*legislation & jurisprudence
MH  - Pregnancy
MH  - Russia
EDAT- 2012/05/23 06:00
MHDA- 2012/08/08 06:00
CRDT- 2012/05/23 06:00
PHST- 2012/05/23 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2012/08/08 06:00 [medline]
PST - ppublish
SO  - Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med. 2011 Nov-Dec;(6):42-3.


PMID- 22611458
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1871-4757 (Print)
IS  - 1871-4757 (Linking)
VI  - 6
IP  - 1
DP  - 2012 Apr
TI  - Do new Ethical Issues Arise at Each Stage of Nanotechnological Development?
PG  - 29-37
AB  - The literature concerning ethical issues associated with nanotechnologies has
      become prolific. However, it has been claimed that ethical problems are only at
      stake with rather sophisticated nanotechnologies such as active nanostructures,
      integrated nanosystems and heterogeneous molecular nanosystems, whereas more
      basic nanotechnologies such as passive nanostructures mainly pose technical
      difficulties. In this paper I argue that fundamental ethical issues are already
      at stake with this more basic kind of nanotechnologies and that ethics impacts
      every kind of nanotechnologies, already from the simplest kind of engineered
      nanoproducts. These ethical issues are mainly associated with the social
      desirability of nanotechnologies, with the difficulties to define
      nanotechnologies properly, with the important uncertainties surrounding
      nanotechnologies, with the threat of 'nano-divide', and with nanotechnology as
      'dual-use technology'.
FAU - Kermisch, Celine
AU  - Kermisch C
AD  - Fonds de la Recherche Scientifique, Universite Libre de Bruxelles CP 175/01, 50, 
      av. F. D. Roosevelt, 1050 Brussels, Belgium.
LA  - eng
PT  - Journal Article
DEP - 20111210
PL  - Netherlands
TA  - Nanoethics
JT  - Nanoethics
JID - 101311055
PMC - PMC3343232
EDAT- 2012/05/23 06:00
MHDA- 2012/05/23 06:01
CRDT- 2012/05/22 06:00
PHST- 2011/09/02 00:00 [received]
PHST- 2011/11/24 00:00 [accepted]
PHST- 2012/05/22 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2012/05/23 06:01 [medline]
AID - 10.1007/s11569-011-0137-8 [doi]
AID - 137 [pii]
PST - ppublish
SO  - Nanoethics. 2012 Apr;6(1):29-37. doi: 10.1007/s11569-011-0137-8. Epub 2011 Dec
      10.


PMID- 22593937
STAT- Publisher
DA  - 20120518
ISBN- 9781439807132
PB  - CRC Press/Taylor & Francis
ED  - 2nd
DP  - 2011
BTI - Herbal Medicine: Biomolecular and Clinical Aspects
AB  - The global popularity of herbal supplements and the promise they hold in treating
      various disease states have caused an unprecedented interest in understanding the
      molecular basis of the biological activity of traditional remedies. This volume
      focuses on presenting current scientific evidence of biomolecular effects of
      selected herbs and their relation to clinical outcome and promotion of human
      health. This book also addresses the ethical challenges of using herbal medicine 
      and its integration into modern, evidence-based medicine. Drawing from the work
      of leading international researchers in different fields, this book contains an
      in-depth scientific examination of effects of individual herbs, as well as their 
      use in the treatment of important diseases such as cancer, cardiovascular
      disease, dermatologic disorders, neurodegenerative disease, and diabetes. Due to 
      the strong associations among oxidative stress, ageing, and disease, the powerful
      antioxidant properties of herbs and spices are also examined. The herbs featured 
      are some of the most widely used remedies and cover a wide range, including
      flowering herbs, fruits and berries, roots and rhizomes, and fungi. To help bring
      a new level of quality control to the production of herbal extracts, the use of
      mass spectrometry and chemometric fingerprinting technology in the authentication
      of herbs is also presented. As the need for effective, affordable health
      promotion and treatment increases, especially in the growing ageing population,
      there is demand for rigorous scientific examination of herbal medicines. This
      timely and comprehensive volume addresses this need and is an important text for 
      medical professionals and researchers, as well as those interested in herbal or
      complementary medicine.
CI  - Copyright (c) 2011 by Taylor and Francis Group, LLC.
FED - Benzie, Iris F. F.
ED  - Benzie IFF
FED - Wachtel-Galor, Sissi
ED  - Wachtel-Galor S
LA  - eng
PT  - Review
PT  - Book
PL  - Boca Raton (FL)
EDAT- 2012/05/18 06:00
MHDA- 2012/05/18 06:00
CDAT- 2012/05/18 06:00
AID - NBK92771 [bookaccession]


PMID- 22593923
STAT- Publisher
DA  - 20120518
ISBN- 9781439807132
PB  - CRC Press/Taylor & Francis
ED  - 2nd
DP  - 2011
TI  - Ethics of Using Herbal Medicine as Primary or Adjunct Treatment and Issues of
      Drug-Herb Interaction
BTI - Herbal Medicine: Biomolecular and Clinical Aspects
CP  - Chapter 21
AB  - This chapter intends to provide a brief overview of the basic ethical principles 
      that are applicable to natural health products (NHPs), including herbal
      medicines. Beneficence, nonmalfeasance (nonmaleficence), and patient autonomy are
      important pillars of biomedical ethics that also apply to the realm of natural
      medicines (Kemper and Cohen 2004). The data about herbal medicine utilization,
      pharmacology, safety, and efficacy are discussed, as well as conditions in which 
      herbal medicines may be used as primary versus adjunct treatment. Issues of
      NHP-drug interactions are reviewed, as they may be synergistic or antagonistic
      and must be considered whenever concomitant use of products occurs. Gaps in
      knowledge are identified, and recommendations are suggested to further explore
      the issues related to NHP-drug interactions.
CI  - Copyright (c) 2011 by Taylor and Francis Group, LLC.
FED - Benzie, Iris F. F.
ED  - Benzie IFF
FED - Wachtel-Galor, Sissi
ED  - Wachtel-Galor S
FAU - Girard, Lauren
AU  - Girard L
FAU - Vohra, Sunita
AU  - Vohra S
LA  - eng
PT  - Review
PT  - Book Chapter
PL  - Boca Raton (FL)
EDAT- 2012/05/18 06:00
MHDA- 2012/05/18 06:00
CDAT- 2012/05/18 06:00
AID - NBK92754 [bookaccession]


PMID- 22591147
OWN - NLM
STAT- MEDLINE
DCOM- 20120926
LR  - 20220409
IS  - 1365-2834 (Electronic)
IS  - 0966-0429 (Linking)
VI  - 20
IP  - 4
DP  - 2012 May
TI  - Psychological empowerment and job satisfaction between Baby Boomer and Generation
      X nurses.
PG  - 451-60
LID - 10.1111/j.1365-2834.2011.01282.x [doi]
AB  - AIM: This paper is a report of a study of differences in nurses' generational
      psychological empowerment and job satisfaction. BACKGROUND: Generations differ in
      work styles such as autonomy, work ethics, involvement, views on leadership, and 
      primary views on what constitutes innovation, quality, and service. METHOD: A
      secondary analysis was conducted from two data sets resulting in a sample of 451 
      registered nurses employed at five hospitals in West Virginia. One data set was
      gathered from a convenience sample and one from a randomly selected sample. Data 
      were collected from 2000 to 2004. RESULTS: Baby Boomer nurses reported higher
      mean total psychological empowerment scores than Generation X nurses. There were 
      no differences in total job satisfaction scores between the generations.
      CONCLUSION: There were significant differences among the generations'
      psychological empowerment scores. Generational differences related to
      psychological empowerment could provide insight into inconsistent findings
      related to nurse job satisfaction. IMPLICATIONS FOR NURSING MANAGEMENT: Nurse
      administrators may consider this evidence when working on strategic plans to
      motivate and entice Generation X nurses and retain Baby Boomers. Although
      implications based on this study are tentative, the results indicate the need for
      administrators to consider the differences between Baby Boomer and Generation X
      nurses.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Sparks, Amy M
AU  - Sparks AM
AD  - West Virginia University School of Nursing, Morgantown, WV 26506-9620, USA.
      asparks@hsc.wvu.edu
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110915
PL  - England
TA  - J Nurs Manag
JT  - Journal of nursing management
JID - 9306050
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - *Attitude of Health Personnel
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - *Job Satisfaction
MH  - Male
MH  - Middle Aged
MH  - Nursing Methodology Research
MH  - Nursing Staff, Hospital/*psychology/statistics & numerical data
MH  - *Power, Psychological
EDAT- 2012/05/18 06:00
MHDA- 2012/09/27 06:00
CRDT- 2012/05/18 06:00
PHST- 2012/05/18 06:00 [entrez]
PHST- 2012/05/18 06:00 [pubmed]
PHST- 2012/09/27 06:00 [medline]
AID - 10.1111/j.1365-2834.2011.01282.x [doi]
PST - ppublish
SO  - J Nurs Manag. 2012 May;20(4):451-60. doi: 10.1111/j.1365-2834.2011.01282.x. Epub 
      2011 Sep 15.


PMID- 22578394
OWN - NLM
STAT- MEDLINE
DCOM- 20120925
LR  - 20200401
IS  - 1527-2966 (Electronic)
IS  - 0099-1767 (Linking)
VI  - 38
IP  - 3
DP  - 2012 May
TI  - Ethical decision making in the emergency department: the Golden Rule.
PG  - 251-3
LID - 10.1016/j.jen.2010.12.012 [doi]
FAU - Friend, Louanne
AU  - Friend L
AD  - Louisiana State University Health Sciences Center School of Nursing, New Orleans,
      LA, USA. mfrien@lsuhsc.edu
LA  - eng
PT  - Journal Article
DEP - 20110222
PL  - United States
TA  - J Emerg Nurs
JT  - Journal of emergency nursing
JID - 7605913
MH  - Decision Making/*ethics
MH  - Emergency Nursing/*ethics
MH  - Emergency Service, Hospital/*ethics
MH  - *Ethics, Nursing
MH  - Humans
EDAT- 2012/05/15 06:00
MHDA- 2012/09/26 06:00
CRDT- 2012/05/15 06:00
PHST- 2009/12/23 00:00 [received]
PHST- 2010/10/18 00:00 [revised]
PHST- 2010/12/15 00:00 [accepted]
PHST- 2012/05/15 06:00 [entrez]
PHST- 2012/05/15 06:00 [pubmed]
PHST- 2012/09/26 06:00 [medline]
AID - S0099-1767(10)00616-1 [pii]
AID - 10.1016/j.jen.2010.12.012 [doi]
PST - ppublish
SO  - J Emerg Nurs. 2012 May;38(3):251-3. doi: 10.1016/j.jen.2010.12.012. Epub 2011 Feb
      22.


PMID- 22574494
OWN - NLM
STAT- MEDLINE
DCOM- 20120612
LR  - 20120511
IS  - 1118-4841 (Print)
IS  - 1118-4841 (Linking)
VI  - 15
IP  - 3
DP  - 2011 Sep
TI  - Stakeholders' views on ethical issues in the practice of in-vitro fertilisation
      and embryo transfer in Nigeria.
PG  - 73-80
AB  - The provision of IVF for the specialized treatment of infertility has grown very 
      rapidly in Nigeria in recent times, especially within the private sector. The
      objective of this study was to document the views of key stakeholders regarding
      salient ethical issues relating to the practice of in-vitro fertilisation (IVF)
      in Nigeria. A think-tank session was convened with participants drawn from
      different backgrounds and disciplines to deliberate on ethical issues in IVF. Ten
      key issues were discussed at this inaugural session. It was unanimously agreed
      that there are no right or wrong answers when considering the ethics and morality
      of IVF as these are principally dependent on choice and circumstances. However
      within the legal and socio-cultural dictates of the Nigerian society, right and
      wrong may be clearly determined on some issues. With the expansion of the IVF
      industry and technology in Nigeria, the need to address related ethical issues
      have become paramount. The forum recommended that it is important that regulatory
      guidelines are put in place to regulate the practice of IVF in Nigeria and to
      protect patients' rights and safety.
FAU - Ajayi, R A
AU  - Ajayi RA
AD  - Assisted Conception Unit, The Bridge Clinic, Victoria Island, Lagos, Nigeria.
      bridge@om.metrong.com
FAU - Dibosa-Osadolor, O J
AU  - Dibosa-Osadolor OJ
LA  - eng
PT  - Journal Article
PL  - Nigeria
TA  - Afr J Reprod Health
JT  - African journal of reproductive health
JID - 9712263
SB  - IM
MH  - *Bioethical Issues
MH  - Culture
MH  - Embryo Transfer/*ethics
MH  - Female
MH  - Fertilization in Vitro/*ethics
MH  - HIV Infections
MH  - Humans
MH  - Nigeria
MH  - Pregnancy
MH  - Surrogate Mothers
MH  - Third-Party Consent
EDAT- 2012/05/12 06:00
MHDA- 2012/06/13 06:00
CRDT- 2012/05/12 06:00
PHST- 2012/05/12 06:00 [entrez]
PHST- 2012/05/12 06:00 [pubmed]
PHST- 2012/06/13 06:00 [medline]
PST - ppublish
SO  - Afr J Reprod Health. 2011 Sep;15(3):73-80.


PMID- 22557779
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 0975-2129 (Electronic)
IS  - 0971-5851 (Linking)
VI  - 32
IP  - 3
DP  - 2011 Jul
TI  - Hyponatremia of non-small cell lung cancer: Indian experience.
PG  - 139-42
LID - 10.4103/0971-5851.92810 [doi]
AB  - BACKGROUND: Hyponatremia is a hazardous complication of lung cancer and its
      treatment. It is seen at presentation in approximately 15% of patients with
      small-cell lung cancer (SCLC) and 1% of patients with non-small cell lung cancer 
      (NSCLC). Platinum compounds used as first-line agents along with taxols
      frequently cause hyponatremia. Till date there is no data on its prevalence in
      patients with advanced lung cancer in the Indian subcontinent. AIM: This study
      was undertaken to find out its incidence before and after institution of
      chemotherapy and to observe the results of treatment of hyponatremia in a group
      of lung cancer patient. MATERIALS AND METHODS: Forty patients with advanced lung 
      cancer (25 patients with stage III disease and 15 with stage IV disease) were
      included in the study. Variables looked at included, but were not limited to,
      serum sodium, serum albumin, serum alkaline phosphatase, serum lactate
      dehydrogenase, and hemoglobin. These variables were measured as per the standard 
      clinical laboratory procedure. No ethics approval was required as these
      parameters are routinely measured in such patients. RESULTS: In the chemo-naive
      state, one out of five cases with SCLC (20%) had hyponatremia at presentation;
      among the 35 cases of NSCLC, 7 patients (20%) had hyponatremia at presentation,
      which is in sharp contrast to earlier reports of 1% prevalence of hyponatremia in
      this group. Among the 27 cases who died within 6 months, 11 had hyponatremia;
      this finding was statistically highly significant. CONCLUSION: In India, NSCLC
      patients are at high risk of having hyponatremia at presentation and this is
      significantly associated with a worse outcome.
FAU - Bose, Chinmoy K
AU  - Bose CK
AD  - Department of Clinical Research, Netaji Subhash Chandra Bose Cancer Research
      Institute, Park Street, Kolkata, West Bengal, India.
FAU - Dey, Subhashis
AU  - Dey S
FAU - Mukhopadhyay, Ashis
AU  - Mukhopadhyay A
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Indian J Med Paediatr Oncol
JT  - Indian journal of medical and paediatric oncology : official journal of Indian
      Society of Medical & Paediatric Oncology
JID - 9604571
PMC - PMC3342719
OTO - NOTNLM
OT  - Hyponatremia
OT  - non-small cell lung cancer
OT  - syndrome of inappropriate secretion of antidiuretic hormone
EDAT- 2012/05/05 06:00
MHDA- 2012/05/05 06:01
CRDT- 2012/05/05 06:00
PHST- 2012/05/05 06:00 [entrez]
PHST- 2012/05/05 06:00 [pubmed]
PHST- 2012/05/05 06:01 [medline]
AID - 10.4103/0971-5851.92810 [doi]
AID - IJMPO-32-139 [pii]
PST - ppublish
SO  - Indian J Med Paediatr Oncol. 2011 Jul;32(3):139-42. doi: 10.4103/0971-5851.92810.


PMID- 22547838
OWN - NLM
STAT- MEDLINE
DCOM- 20120614
LR  - 20211021
IS  - 0008-5286 (Print)
IS  - 0008-5286 (Linking)
VI  - 52
IP  - 11
DP  - 2011 Nov
TI  - Veterinary medical ethics.
PG  - 1172
FAU - Rollin, Bernard E
AU  - Rollin BE
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Vet J
JT  - The Canadian veterinary journal = La revue veterinaire canadienne
JID - 0004653
SB  - IM
MH  - Animal Husbandry/*ethics/*methods
MH  - Animal Welfare/*ethics
MH  - Animals
MH  - Canada
MH  - Humans
MH  - Veterinary Medicine/*ethics
PMC - PMC3196009
EDAT- 2012/05/02 06:00
MHDA- 2012/06/15 06:00
CRDT- 2012/05/02 06:00
PHST- 2012/05/02 06:00 [entrez]
PHST- 2012/05/02 06:00 [pubmed]
PHST- 2012/06/15 06:00 [medline]
PST - ppublish
SO  - Can Vet J. 2011 Nov;52(11):1172.


PMID- 22547836
OWN - NLM
STAT- MEDLINE
DCOM- 20120614
LR  - 20211021
IS  - 0008-5286 (Print)
IS  - 0008-5286 (Linking)
VI  - 52
IP  - 11
DP  - 2011 Nov
TI  - The ethics of pet food marketing - a comment.
PG  - 1161
FAU - Rumney, H J
AU  - Rumney HJ
LA  - eng
PT  - Letter
PT  - Comment
PL  - Canada
TA  - Can Vet J
JT  - The Canadian veterinary journal = La revue veterinaire canadienne
JID - 0004653
SB  - IM
CON - Can Vet J. 2011 Aug;52(8):824, 826. PMID: 22294789
MH  - Animal Feed/*economics
MH  - Animals
MH  - *Ethics, Professional
MH  - Humans
MH  - Marketing/*ethics
MH  - Veterinary Medicine/*ethics
PMC - PMC3196007
EDAT- 2012/05/02 06:00
MHDA- 2012/06/15 06:00
CRDT- 2012/05/02 06:00
PHST- 2012/05/02 06:00 [entrez]
PHST- 2012/05/02 06:00 [pubmed]
PHST- 2012/06/15 06:00 [medline]
PST - ppublish
SO  - Can Vet J. 2011 Nov;52(11):1161.


PMID- 22545907
OWN - NLM
STAT- MEDLINE
DCOM- 20120529
LR  - 20191210
IS  - 1037-6178 (Print)
IS  - 1037-6178 (Linking)
VI  - 40
IP  - 1
DP  - 2011 Dec
TI  - Community-based child health nurses: an exploration of current practice.
PG  - 71-86
LID - 10.5172/conu.2011.40.1.71 [doi]
AB  - The purpose of this research was to define, the practice domain of
      community-based child health nursing in light of widespread political, economic
      and social changes in Western Australia. The project was conducted by a group of 
      nurse researchers with experience in child health nursing from the School of
      Nursing and Midwifery at Curtin University and the Child and Adolescent Community
      Health Division at the Department of Health, Western Australia. The overall aim
      of the project was to map the scope of nursing practice in the community child
      health setting in Western Australia and to identify the decision making framework
      that underpins this nursing specialty. Given the widespread social, economic and 
      health service management changes, it was important for nurses involved with, or 
      contemplating a career in, community-based child health to have the role
      accurately defined. In addition, consumer expectations of the service needed to
      be explored within the current climate. A descriptive qualitative study was used 
      for this project. A purposive sample of 60 participants was drawn from the pool
      of child health nurses in the South Metropolitan Community Health Service, North 
      Metropolitan Health Service and Western Australian Country Health Service.
      Following ethical approval data was collected via participants keeping a 2-week
      work diary. The data was coded and thematic analysis was applied. Several themes 
      emerged from the analysis which were validated by follow up focus group
      interviews with participants. This clearly demonstrated common, recurring issues.
      The results identified that the community-based child health nurses are currently
      undertaking a more complex and expanded child health service role for an
      increasingly diverse client population, over their traditional practices which
      are still maintained. Excessive workloads and lack of human and non human
      resources also presented challenges. There are increasing requirements for child 
      health nurses to engage in community development and capacity building, often
      through a multidisciplinary partnership, which requires them to have sound
      brokerage and facilitation skills to enable community inclusion and inter-agency 
      collaboration at the local level. The study has highlighted the importance and
      multifaceted nature of the role of the community-based child health nurse. To
      enable them to function optimally, the following suggestions/recommendations are 
      offered. These being: More physical resources be allocated to community-based
      child health nursing More resources allocated to assist community-based child
      health nurses to support culturally and linguistically diverse families Mapping
      of child health nurses' workloads The development of community health client
      dependency rating criteria reflecting the social determinants of health in order 
      for health service refinement of staffing allocations based on an acuity scale
      Specific staff development opportunities to reflect the increased workload
      complexity Managerial support for the implementation of formal clinical
      (reflective) supervision Additional clerical assistance with non-nursing duties.
FAU - Borrow, Stephanie
AU  - Borrow S
AD  - Valley and Hills Child and Adolescent Health Service, Department of Health,
      Western Australia, Perth, Australia.
FAU - Munns, Ailsa
AU  - Munns A
FAU - Henderson, Saras
AU  - Henderson S
LA  - eng
PT  - Journal Article
PT  - Validation Study
PL  - United States
TA  - Contemp Nurse
JT  - Contemporary nurse
JID - 9211867
MH  - Adolescent
MH  - Child
MH  - Child Health Services/*organization & administration
MH  - *Community Health Nursing
MH  - Focus Groups
MH  - Humans
MH  - Queensland
MH  - Western Australia
EDAT- 2012/05/02 06:00
MHDA- 2012/05/30 06:00
CRDT- 2012/05/02 06:00
PHST- 2012/05/02 06:00 [entrez]
PHST- 2012/05/02 06:00 [pubmed]
PHST- 2012/05/30 06:00 [medline]
AID - 10.5172/conu.2011.40.1.71 [doi]
PST - ppublish
SO  - Contemp Nurse. 2011 Dec;40(1):71-86. doi: 10.5172/conu.2011.40.1.71.


PMID- 22543418
OWN - NLM
STAT- MEDLINE
DCOM- 20120531
LR  - 20191112
IS  - 1718-3340 (Print)
VI  - 13
IP  - 1
DP  - 2011
TI  - A qualitative inquiry into the application of verbal autopsy for a mortality
      surveillance system in a rural community of southern India.
PG  - 30-9
AB  - The aim of this investigation was to identify operational and ethical issues
      encountered in the application of verbal autopsy (VA) in a rural community in
      south India. A qualitative study involving semi-structured interviews was
      conducted with 183 bereaved caregivers in rural Andhra Pradesh, India. Simple
      descriptive analysis was undertaken. Only 16% of adult deaths and 27% of child
      deaths occurred in healthcare settings. Healthcare utilization for the terminal
      illness was reported in two thirds of medical (non-injury) causes of death.
      Supporting medical evidence was available in <10% of cases to supplement the
      interpretation of verbal autopsies. About 14% of bereaved caregivers refused to
      give written consent but provided oral consent. Additional ethical concerns
      included inability to ensure privacy in 15% of interviews and unsolicited
      information from unauthorized neighbours in 5% of cases. Such methodological,
      logistical and ethical issues operate to impact on the quality of VAs.
      Consideration of these issues would strengthen ongoing efforts in the
      harmonization of VA procedures.
FAU - Mony, Prem K
AU  - Mony PK
AD  - St. John's Research Institute, St. John's National Academy of Health Sciences,
      Bangalore, India. premkmony@gmail.com
FAU - Vaz, Mario
AU  - Vaz M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Canada
TA  - World Health Popul
JT  - World health & population
JID - 101307691
SB  - IM
MH  - Autopsy/ethics/*methods
MH  - Cause of Death
MH  - Female
MH  - Grief
MH  - Humans
MH  - India
MH  - Male
MH  - *Mortality
MH  - Qualitative Research
MH  - Rural Population/*statistics & numerical data
MH  - *Sentinel Surveillance
MH  - Socioeconomic Factors
EDAT- 2012/05/01 06:00
MHDA- 2012/06/01 06:00
CRDT- 2012/05/01 06:00
PHST- 2012/05/01 06:00 [entrez]
PHST- 2012/05/01 06:00 [pubmed]
PHST- 2012/06/01 06:00 [medline]
AID - 10.12927/whp.2011.22514 [doi]
PST - ppublish
SO  - World Health Popul. 2011;13(1):30-9. doi: 10.12927/whp.2011.22514.


PMID- 22532905
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120615
LR  - 20211021
IS  - 2196-8934 (Electronic)
IS  - 1998-1929 (Linking)
VI  - 4
IP  - 1
DP  - 2011 Summer
TI  - Automating academic literature searches with RSS Feeds and Google Reader().
PG  - 63-9
AB  - Behavior analytic practitioners have an ethical obligation to stay abreast of the
      most recent research developments in their areas of expertise. Although
      conducting frequent and comprehensive literature searches is one way to meet this
      mandate, doing so can be a time intensive process. One way to reduce the effort
      involved in this process is setting up automated literature and news searches
      using RSS feeds via programs like Google Reader(). This paper outlines the steps 
      necessary for setting up a Google Reader() account and creating customized RSS
      feeds based on searches of the National Center for Biotechnology Information
      (NCBI) PubMed database and the World Wide Web.
FAU - Dubuque, Erick M
AU  - Dubuque EM
AD  - University of Nevada, Reno.
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Behav Anal Pract
JT  - Behavior analysis in practice
JID - 101515653
PMC - PMC3196208
OTO - NOTNLM
OT  - *Google Reader
OT  - *PubMed
OT  - *RSS feeds
OT  - *literature searches
EDAT- 2012/04/26 06:00
MHDA- 2012/04/26 06:01
CRDT- 2012/04/26 06:00
PHST- 2012/04/26 06:00 [entrez]
PHST- 2012/04/26 06:00 [pubmed]
PHST- 2012/04/26 06:01 [medline]
AID - 10.1007/BF03391776 [doi]
PST - ppublish
SO  - Behav Anal Pract. 2011 Summer;4(1):63-9. doi: 10.1007/BF03391776.


PMID- 22532734
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120830
LR  - 20211021
IS  - 2196-8918 (Electronic)
IS  - 0738-6729 (Linking)
VI  - 34
IP  - 1
DP  - 2011 Spring
TI  - The association for behavior analysis international position statement on
      restraint and seclusion.
PG  - 103-10
AB  - A task force authorized by the Executive Council of the Association for Behavior 
      Analysis International (ABAI) generated the statement below concerning the
      techniques called restraint and seclusion. Members of the task force
      independently reviewed the scientific literature concerning restraint and
      seclusion and agreed unanimously to the content of the statement. The Executive
      Council accepted the statement, and it was subsequently approved by a two-thirds 
      majority vote of the general membership. It now constitutes official ABAI policy.
      The position statement is posted on the ABAI Web site
      (www.abainternational.org/ABA/statements/RestraintSeclusion.asp). The purpose of 
      the position statement is to provide guidance to behavior analysts and other
      professionals interested in the position of ABAI on these controversial topics.
      In extreme cases, abuses of procedures erroneously used in the name of behavior
      analysis are not defensible. On the other hand, behavior analysts acting
      ethically and in good faith are provided with guidelines for sound and acceptably
      safe practice. To the extent that behavior-analytic positions influence public
      policy and law, this statement can be presented to officials and lawmakers to
      guide informed decision making. At the conclusion of the document, a bibliography
      is provided of articles and presentations considered by one or more task force
      members in developing the position statement.
FAU - Vollmer, Timothy R
AU  - Vollmer TR
AD  - University of Florida.
FAU - Hagopian, Louis P
AU  - Hagopian LP
FAU - Bailey, Jon S
AU  - Bailey JS
FAU - Dorsey, Michael F
AU  - Dorsey MF
FAU - Hanley, Gregory P
AU  - Hanley GP
FAU - Lennox, David
AU  - Lennox D
FAU - Riordan, Mary M
AU  - Riordan MM
FAU - Spreat, Scott
AU  - Spreat S
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Behav Anal
JT  - The Behavior analyst
JID - 8303067
PMC - PMC3089400
OTO - NOTNLM
OT  - ethics
OT  - position statement
OT  - restraint
OT  - seclusion
EDAT- 2012/04/26 06:00
MHDA- 2012/04/26 06:01
CRDT- 2012/04/26 06:00
PHST- 2012/04/26 06:00 [entrez]
PHST- 2012/04/26 06:00 [pubmed]
PHST- 2012/04/26 06:01 [medline]
AID - 10.1007/BF03392238 [doi]
PST - ppublish
SO  - Behav Anal. 2011 Spring;34(1):103-10. doi: 10.1007/BF03392238.


PMID- 22530524
OWN - NLM
STAT- MEDLINE
DCOM- 20120531
LR  - 20120425
IS  - 0001-4079 (Print)
IS  - 0001-4079 (Linking)
VI  - 195
IP  - 6
DP  - 2011 Jun
TI  - [Virtual endoscopic navigation and body transparency based on computed
      tomography. A step towards in vivo imaging].
PG  - 1385-97
AB  - Progress in HR-CTdata processing has led to lower X-ray exposure and to better
      diagnostic performance. We describe 19 adult patients (among 5000) examined by HR
      CT with 64 detectors, acquisition and exposure protocols in mSv, spiral, 0.6-mm
      slices, 5To PACS. After the two usual processing steps (60 gray values, 5122 and 
      10242 matrices, dedicated workstations for coronaroscopy and virtual coloscopy,
      2D multiplanar reformation, surfacic, 3D volumes with dissection and navigation),
      a third original data processing step on additional workstations was added.
      Variable matrix extrapolated images, flexible colored curves (different from
      anatomical conventions), lighting (sources) and transparencies (unavailable with 
      traditional endoscopy) were used. The digital film is a 16-minute "journey
      "consisting of 19 endo-body navigations in 5 regions, from the head to the
      bronchi, from the heart to the coronary arteries, and from the digestive tract to
      the abdomen and pelvis. One possible application is post-operative verification
      of an aortic graft. The movie is illustrated here with ten plates. This new
      approach is cost-effective and beneficial for the patient, in terms of early
      diagnosis and therapeutic follow-up. Ethical issues are also examined.
FAU - Cabanis, Emmanuel-Alain
AU  - Cabanis EA
AD  - Membre de l'Academie nationale de medecine. emmanuel.a.cabanis@gmail.com
FAU - Gombergh, Rodolphe
AU  - Gombergh R
FAU - Castro, Albert
AU  - Castro A
FAU - Gandjbakhch, Iradj
AU  - Gandjbakhch I
FAU - Iba-Zizen, Marie-Therese
AU  - Iba-Zizen MT
FAU - Dubois, Francois
AU  - Dubois F
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Navigation endoscopique et transparences corporelles par scanner a RX, une etape 
      en imagerie in vivo.
PL  - Netherlands
TA  - Bull Acad Natl Med
JT  - Bulletin de l'Academie nationale de medecine
JID - 7503383
SB  - IM
MH  - Endoscopy/*methods
MH  - Humans
MH  - *Imaging, Three-Dimensional
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2012/04/26 06:00
MHDA- 2012/06/01 06:00
CRDT- 2012/04/26 06:00
PHST- 2012/04/26 06:00 [entrez]
PHST- 2012/04/26 06:00 [pubmed]
PHST- 2012/06/01 06:00 [medline]
PST - ppublish
SO  - Bull Acad Natl Med. 2011 Jun;195(6):1385-97.


PMID- 22529498
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 0300-1652 (Print)
IS  - 0300-1652 (Linking)
VI  - 52
IP  - 4
DP  - 2011 Oct
TI  - Ethical dilemmas in dentistry.
PG  - 205-6
LID - 10.4103/0300-1652.93788 [doi]
FAU - Sheriff, S Omer
AU  - Sheriff SO
AD  - Department of Conservative Dentistry and Endodontics, Adhi Parasakthi Dental
      College, Melmaruvathur, Tamil Nadu, India.
FAU - Sheriff, Dhastagir Sultan
AU  - Sheriff DS
LA  - eng
PT  - Journal Article
PL  - Nigeria
TA  - Niger Med J
JT  - Nigerian medical journal : journal of the Nigeria Medical Association
JID - 0315137
PMC - PMC3329085
EDAT- 2012/04/25 06:00
MHDA- 2012/04/25 06:01
CRDT- 2012/04/25 06:00
PHST- 2012/04/25 06:00 [entrez]
PHST- 2012/04/25 06:00 [pubmed]
PHST- 2012/04/25 06:01 [medline]
AID - 10.4103/0300-1652.93788 [doi]
AID - NMJ-52-205 [pii]
PST - ppublish
SO  - Niger Med J. 2011 Oct;52(4):205-6. doi: 10.4103/0300-1652.93788.


PMID- 22521017
OWN - NLM
STAT- MEDLINE
DCOM- 20120806
LR  - 20120423
IS  - 1646-0758 (Electronic)
IS  - 0870-399X (Linking)
VI  - 24
IP  - 4
DP  - 2011 Jul-Aug
TI  - [Forensic telepsychiatry in Portugal: a few reflections].
PG  - 595-602
AB  - Forensic Telepsychiatry has had growing usage in countries such as the USA and
      England in the last decade, due to ongoing development of technologies which
      allow a better access to mental health care in needed populations, and improve
      the outcome of technicians' work, while facing a more demanding performance of
      Mental Health facilities. In this article we make a revision of literature
      concerning applications of Forensic Telepsychiatry, analyzing its potencialities 
      and limits in Portugal. The literature shows positive evidence about efficiency, 
      cost and acceptance, to both patients and doctors. On the other hand, several
      authors rise issues related to technical, ethical and legal aspects, such as
      restrictions to its application in forensics; privacy, confidentiality, safety,
      consent, diagnostic skills and professional responsibility. Forensic
      Telepsychiatry has shown special utility in remote rural populations with poor
      access to mental health care, victims of domestic violence, victims of sexual
      abuse, minor inpatients in correctional facilities and convicts in prisons. It
      may improve exchange of information with courts and penitentiaries, and
      production of evidence through quick and efficacious auditing. It has also been
      used in court to communicate forensic reports concerning mental health patients, 
      to clarify issues related to psychiatric evaluations and testify in criminal and 
      civil courts. Besides the literature revision, three areas of applicability for
      Forensic Telepsychiatry in Portugal are discussed in this article: teleconference
      for experts - psychiatrists and psychologists - testifying in court sessions;
      psychiatric and psychological evaluations through teleconference; expert
      auditions through a hotline, designed to provide specialized support to courts - 
      both for urgent guidance and clarification. The reflections and proposals
      included in this article aim to make way to empirical studies which could
      evaluate the applicability of a more widespread usage of Forensic Telepsychiatry 
      in Portugal in the near future.
FAU - Pereira, Bruno
AU  - Pereira B
AD  - Servico de Psiquiatria, Hospital do Divino Espirito Santo, Ponta Delgada,
      Portugal.
FAU - Cintra, Pedro
AU  - Cintra P
FAU - Vieira, Fernando
AU  - Vieira F
FAU - Santos, Jorge Costa
AU  - Santos JC
LA  - por
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Telepsiquiatria forense em portugal: algumas reflexoes.
DEP - 20111212
PL  - Portugal
TA  - Acta Med Port
JT  - Acta medica portuguesa
JID - 7906803
SB  - IM
MH  - *Forensic Psychiatry/methods
MH  - Portugal
MH  - *Telemedicine
EDAT- 2012/04/24 06:00
MHDA- 2012/08/07 06:00
CRDT- 2012/04/24 06:00
PHST- 2009/11/19 00:00 [received]
PHST- 2010/03/21 00:00 [accepted]
PHST- 2012/04/24 06:00 [entrez]
PHST- 2012/04/24 06:00 [pubmed]
PHST- 2012/08/07 06:00 [medline]
PST - ppublish
SO  - Acta Med Port. 2011 Jul-Aug;24(4):595-602. Epub 2011 Dec 12.


PMID- 22521015
OWN - NLM
STAT- MEDLINE
DCOM- 20120806
LR  - 20120423
IS  - 1646-0758 (Electronic)
IS  - 0870-399X (Linking)
VI  - 24
IP  - 4
DP  - 2011 Jul-Aug
TI  - [Clinical effectiveness and economical evaluation of preventive vaccination].
PG  - 565-86
AB  - The value of mass vaccination as a preventive measure for infectious diseases is 
      one of the most important advances of modern Medicine. The impact on incidence of
      several infectious diseases, until recently responsible for significant morbidity
      and mortality at world level, is well proved in a series of high quality
      epidemiological studies. In this scientific review we aimed firstly to briefly
      resume the history of mass vaccination and its scientists, responsible for
      synthesis and marketing of these drugs. In second place we present a group of a
      few disease preventable by vaccines as well as the Portuguese National
      Vaccination Plan and its benefits. In third place we identified groups of
      subjects in which a well structured vaccination plan is particularly important,
      as well as the correspondent diseases to be covered by vaccination. Fourthly, we 
      discussed the ethical considerations of vaccination, and its tensions between
      subject autonomy and society advantages in com pulsive programs. Fifthly, we
      analyzed clinical effectiveness of vaccines through the concept of herd immunity,
      clinical evaluation of immune response to vaccines and some examples of
      systematic reviews on three relevant diseases (influenza, meningococcal and
      pneumococcal infections). In sixth place we discussed vaccine safety presenting
      monitoring methods of vaccination risks, as well as discussing the public myths
      concerning vaccines. Finally we present a economic analysis of preventive
      vaccination with a review of some published literature on specific diseases. We
      conclude that mass vaccination is a efficacious preventive measure, as well as a 
      economic rational choice, and that this public health intervention should be a
      pillar of a modern preventive system.
FAU - Vaz Carneiro, Antonio
AU  - Vaz Carneiro A
AD  - Centro de Estudos de Medicina Baseada na Evidencia, Faculdade de Medicina da
      Universidade de Lisboa, Portugal.
FAU - Belo, Ana Isabel
AU  - Belo AI
FAU - Gouveia, Miguel
AU  - Gouveia M
FAU - Costa, Joao
AU  - Costa J
FAU - Borges, Margarida
AU  - Borges M
LA  - por
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
TT  - Efectividade clinica e analise economica da vacinacao preventiva.
DEP - 20111212
PL  - Portugal
TA  - Acta Med Port
JT  - Acta medica portuguesa
JID - 7906803
RN  - 0 (Influenza Vaccines)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Child
MH  - Child, Preschool
MH  - Communicable Disease Control/*economics/*standards
MH  - Costs and Cost Analysis
MH  - Humans
MH  - Immunity
MH  - Immunization Programs/*economics/ethics/*standards
MH  - Infant
MH  - Influenza Vaccines/economics
MH  - Middle Aged
MH  - Risk Factors
MH  - Vaccination/adverse effects/*economics/ethics/*standards
MH  - Young Adult
EDAT- 2012/04/24 06:00
MHDA- 2012/08/07 06:00
CRDT- 2012/04/24 06:00
PHST- 2012/04/24 06:00 [entrez]
PHST- 2012/04/24 06:00 [pubmed]
PHST- 2012/08/07 06:00 [medline]
PST - ppublish
SO  - Acta Med Port. 2011 Jul-Aug;24(4):565-86. Epub 2011 Dec 12.


PMID- 22514816
STAT- Publisher
DA  - 20120420
ISBN- 9780309220392
ISBN- 0309220394
PB  - National Academies Press (US)
CTI - The National Academies Collection: Reports funded by National Institutes of
      Health
DP  - 2011
BTI - Chimpanzees in Biomedical and Behavioral Research: Assessing the Necessity
AB  - The task given to the committee (Committee on the Use of Chimpanzees in
      Biomedical and Behavioral Research) by the NIH (National Institutues of Health)
      asked two questions about the need for chimpanzees in research: (1) Is biomedical
      research with chimpanzees "necessary for research discoveries and to determine
      the safety and efficacy of new prevention or treatment strategies?" and (2) Is
      behavioral research using chimpanzees "necessary for progress in understanding
      social, neurological, and behavioral factors that influence the development,
      prevention, or treatment of disease?" In responding to these questions, the
      committee concluded that the potential reasons for undertaking biomedical and
      behavioral research as well as the protocols used in each area are different
      enough to require different sets of criteria. However, the committee developed
      both sets of criteria guided by the following three principles: 1. The knowledge 
      gained must be necessary to advance the public's health; 2. There must be no
      other research model by which the knowledge could be obtained, and the research
      cannot be ethically performed on human subjects; 3. The animals used in the
      proposed research must be maintained either in ethologically appropriate physical
      and social environments or in natural habitats. These principles are the basis
      for the specific criteria that the committee established to assess current and
      future use of the chimpanzee in biomedical and behavioral research (see
      Recommendations 1 and 2).
CI  - Copyright (c) 2011, National Academy of Sciences.
CN  - Institute of Medicine (US) and National Research Council (US) Committee on the
      Use of Chimpanzees in Biomedical and Behavioral Research
FED - Altevogt, Bruce M
ED  - Altevogt BM
FED - Pankevich, Diana E
ED  - Pankevich DE
FED - Shelton-Davenport, Marilee K
ED  - Shelton-Davenport MK
FED - Kahn, Jeffrey P
ED  - Kahn JP
LA  - eng
GR  - N01 OD042139/NIH HHS/United States
PT  - Review
PT  - Book
PL  - Washington (DC)
EDAT- 2012/04/20 06:00
MHDA- 2012/04/20 06:00
CDAT- 2012/04/20 06:00
AID - NBK91445 [bookaccession]
AID - 10.17226/13257 [doi]


PMID- 22514813
STAT- Publisher
DA  - 20120420
ISBN- 9780309215022
ISBN- 0309215021
PB  - National Academies Press (US)
CTI - The National Academies Collection: Reports funded by National Institutes of
      Health
DP  - 2011
BTI - Animal Research in a Global Environment: Meeting the Challenges: Proceedings of
      the November 2008 International Workshop
AB  - Fully cognizant of the demands and cautions related to the globalization of
      animal research, ILAR (Institute for Laboratory Animal Research) appointed a
      Workshop Steering Committee, composed of US and foreign individuals from
      academia, industry, and the nonprofit sector, to design the program for the 2008 
      workshop such that session speakers might identify and promote better
      understanding of important challenges in the conduct of animal research across
      country boundaries. These challenges appear in the sourcing of animals; the
      quality of veterinary care; appropriately qualified and competent staff; the
      provision of a suitable environment (including nutritious food and potable water)
      for animals, both during transport and at the institution; ethical review of the 
      proposed work and ongoing oversight of the animal program; suitable facilities
      and equipment in which to conduct the work; appropriate policies and procedures; 
      and protection of the personnel involved in the animal program.
CI  - Copyright (c) 2011, National Academy of Sciences.
CN  - National Research Council (US) Institute for Laboratory Animal Research
LA  - eng
GR  - N01 OD042139/NIH HHS/United States
PT  - Review
PT  - Book
PL  - Washington (DC)
EDAT- 2012/04/20 06:00
MHDA- 2012/04/20 06:00
CDAT- 2012/04/20 06:00
AID - NBK91434 [bookaccession]
AID - 10.17226/13175 [doi]


PMID- 22512096
OWN - NLM
STAT- MEDLINE
DCOM- 20120531
LR  - 20140404
IS  - 2306-4102 (Print)
IS  - 2306-4102 (Linking)
VI  - 25
IP  - 6
DP  - 2011 Nov-Dec
TI  - [Ethics in medical training].
PG  - 343-5
FAU - Guinchard-y-Sanchez, E
AU  - Guinchard-y-Sanchez E
LA  - spa
PT  - Editorial
TT  - La etica en la formacion del medico.
PL  - Mexico
TA  - Acta Ortop Mex
JT  - Acta ortopedica mexicana
JID - 101190312
SB  - IM
MH  - Education, Medical/*ethics
EDAT- 2012/04/20 06:00
MHDA- 2012/06/01 06:00
CRDT- 2012/04/20 06:00
PHST- 2012/04/20 06:00 [entrez]
PHST- 2012/04/20 06:00 [pubmed]
PHST- 2012/06/01 06:00 [medline]
PST - ppublish
SO  - Acta Ortop Mex. 2011 Nov-Dec;25(6):343-5.


PMID- 22507489
OWN - NLM
STAT- MEDLINE
DCOM- 20120816
LR  - 20151119
IS  - 1445-2197 (Electronic)
IS  - 1445-1433 (Linking)
VI  - 82
IP  - 1-2
DP  - 2012 Jan-Feb
TI  - Current medical students' understanding of Surgical Education and Training.
PG  - 12-6
LID - 10.1111/j.1445-2197.2011.05944.x [doi]
AB  - BACKGROUND: The current Surgical Education and Training (SET) programme in
      Australia and New Zealand has been implemented to streamline surgical training.
      As applications to the SET programme can occur as early as the 2nd post-graduate 
      year, early preparation is vital to ensure a successful outcome in gaining a SET 
      position. We wish to demonstrate to what degree medical students are aware of the
      SET structure and application requirements to determine if further assistance to 
      future SET candidates is required. METHODS: A standardized questionnaire was
      delivered to students of an Australian Medical School via an online medium.
      Ethics approval was granted, and all surveys were completed anonymously and
      voluntarily. One hundred eighty-two completed surveys were received. RESULTS:
      Eighteen percent of surveyed participants felt they had a good understanding of
      the SET programme, with 82% stating they had minimal or no understanding of the
      programme. Fourteen percent felt they had the information needed to pursue a
      career in surgery. Fifty-three percent were unaware that the College outlined
      areas of core competencies required in their training, with 75% unable to name
      any core competencies. CONCLUSION: There are a large proportion of medical
      students potentially considering a career in surgery. However, only a small
      number feel that they have been adequately equipped throughout their medical
      course to understand the steps needed to build a strong application for SET.
CI  - (c) 2011 The Authors. ANZ Journal of Surgery (c) 2011 Royal Australasian College 
      of Surgeons.
FAU - Farah, Sam
AU  - Farah S
AD  - Department of Surgery (Monash Medical Centre), Monash University, Clayton,
      Victoria, Australia. sfarah@me.com
FAU - Winter, Matthew
AU  - Winter M
FAU - Smith, Julian A
AU  - Smith JA
LA  - eng
PT  - Journal Article
DEP - 20111215
PL  - Australia
TA  - ANZ J Surg
JT  - ANZ journal of surgery
JID - 101086634
SB  - IM
MH  - Australia
MH  - Career Choice
MH  - Clinical Competence
MH  - *Education, Medical, Graduate
MH  - Female
MH  - General Surgery/*education
MH  - Humans
MH  - Male
MH  - *School Admission Criteria
MH  - Students, Medical
MH  - Surveys and Questionnaires
EDAT- 2012/04/18 06:00
MHDA- 2012/08/17 06:00
CRDT- 2012/04/18 06:00
PHST- 2012/04/18 06:00 [entrez]
PHST- 2012/04/18 06:00 [pubmed]
PHST- 2012/08/17 06:00 [medline]
AID - 10.1111/j.1445-2197.2011.05944.x [doi]
PST - ppublish
SO  - ANZ J Surg. 2012 Jan-Feb;82(1-2):12-6. doi: 10.1111/j.1445-2197.2011.05944.x.
      Epub 2011 Dec 15.


PMID- 22507406
OWN - NLM
STAT- MEDLINE
DCOM- 20120816
LR  - 20130130
IS  - 1445-2197 (Electronic)
IS  - 1445-1433 (Linking)
VI  - 81
IP  - 12
DP  - 2011 Dec
TI  - Surgical ethics, law and mandatory reporting.
PG  - 855-6
LID - 10.1111/j.1445-2197.2011.05928.x [doi]
FAU - Maddern, Guy
AU  - Maddern G
AD  - Discipline of Surgery, University of Adelaide, South Australia, Australia.
FAU - Smith, Joseph Wayne
AU  - Smith JW
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - ANZ J Surg
JT  - ANZ journal of surgery
JID - 101086634
SB  - IM
CIN - ANZ J Surg. 2012 May;82(5):379. PMID: 23305058
MH  - Australia
MH  - *General Surgery/ethics/legislation & jurisprudence
MH  - Humans
MH  - *Mandatory Reporting/ethics
MH  - Professional Impairment/*legislation & jurisprudence
EDAT- 2012/04/18 06:00
MHDA- 2012/08/17 06:00
CRDT- 2012/04/18 06:00
PHST- 2012/04/18 06:00 [entrez]
PHST- 2012/04/18 06:00 [pubmed]
PHST- 2012/08/17 06:00 [medline]
AID - 10.1111/j.1445-2197.2011.05928.x [doi]
PST - ppublish
SO  - ANZ J Surg. 2011 Dec;81(12):855-6. doi: 10.1111/j.1445-2197.2011.05928.x.


PMID- 22504983
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1090-3941 (Print)
IS  - 1090-3941 (Linking)
VI  - 21
DP  - 2011 Dec
TI  - Comparison of Recurrence Rates in Obese and Non-Obese Patients Undergoing Ventral
      Hernia Repair with Lighter-Weight, Partially Absorbable Mesh.
PG  - 140-3
AB  - Lighter-weight, large pore meshes with absorbable layers are designed for
      intra-abdominal placement in laparoscopic ventral hernia repair. This
      retrospective review of 86 patients who underwent ventral hernia repair with
      PROCEED Surgical Mesh (Ethicon, Inc., Somerville, NJ) represents an evaluation of
      a cohort of patients implanted with this mesh. All patients implanted with
      PROCEED Mesh for ventral hernia repair between October 2006 and December 2007
      were contacted and asked to participate in an evaluation of their hernia repair. 
      Patients were evaluated for pain, recurrence of their hernia and other potential 
      complications. Eight patients underwent open repair; all others were performed
      laparoscopically. One patient continued to have pain at 1 year. Twelve developed 
      seromas early on and 5 required drainage by a single puncture each. None
      persisted. There were 4 recurrences with none in patients with a Body Mass Index 
      3 32. One case of abdominal wall cellulitis responded to antibiotics. There were 
      no wound infections, mesh infections, bowel obstructions or enteric fistulas.
      This study demonstrates the utility of a lighter-weight, large pore, partially
      absorbable mesh for intraperitoneal use in laparoscopic ventral hernia repair and
      indicates this mesh is strong enough for use in obese patients.
FAU - Tollens, Tim
AU  - Tollens T
AD  - General Surgeon, Imelda Hospital, Bonheiden, Belgium.
FAU - Speybrouck, Sabrina
AU  - Speybrouck S
AD  - Registrar in Surgery, Imelda Hospital, Bonheiden, Belgium.
FAU - Devroe, Kurt
AU  - Devroe K
AD  - Registrar in Surgery, Imelda Hospital, Bonheiden, Belgium.
FAU - Terry, Catherine
AU  - Terry C
AD  - Registrar in Surgery, Sint Nikolaus Hospital, Eupen, Belgium.
FAU - Alevoet, Chris
AU  - Alevoet C
AD  - Consultant Surgeon, Imelda Hospital, Bonheiden, Belgium.
FAU - Divilio, L Thomas
AU  - Divilio LT
AD  - Ethicon, Inc., Somerville, New Jersey.
FAU - Patel, Bababhai
AU  - Patel B
AD  - Ethicon, Inc., Somerville, New Jersey.
FAU - Vanrykel, Jean-Pierre Vanrykel
AU  - Vanrykel JP
AD  - Head of Department, Imelda Hospital, Bonheiden, Belgium.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Surg Technol Int
JT  - Surgical technology international
JID - 9604509
SB  - IM
EDAT- 2012/04/17 06:00
MHDA- 2012/04/17 06:01
CRDT- 2012/04/17 06:00
PHST- 2012/04/17 06:00 [entrez]
PHST- 2012/04/17 06:00 [pubmed]
PHST- 2012/04/17 06:01 [medline]
AID - sti21/140 [pii]
PST - ppublish
SO  - Surg Technol Int. 2011 Dec;21:140-3.


PMID- 22484889
OWN - NLM
STAT- MEDLINE
DCOM- 20120925
LR  - 20191210
IS  - 1998-3603 (Electronic)
IS  - 0970-9290 (Linking)
VI  - 22
IP  - 6
DP  - 2011 Nov-Dec
TI  - Is the concept of ethics misplaced in the migration of Indian trained dentists to
      Australia? The need for better international co-operation in dentistry.
PG  - 866-8
LID - 10.4103/0970-9290.94689 [doi]
AB  - The purpose of this article is to discuss the ethics involved in the migration of
      Indian trained dentists to Australia. It develops from interviews of senior oral 
      health leaders in both the countries to provide evidence that ethics in migration
      is diluted in practice and to suggest that migratory procedures in both the
      countries should be reconsidered. There is also an urgent need for more organized
      bilateral communication and negotiation between the concerned organizations of
      both the countries (dental councils, immigration departments and research
      centers) in order to prevent the somewhat irreversible and intensive brain drain 
      of top quality dentists from India to Australia. We would suggest as a starting
      point better monitoring of the migrants' academic and social background, the
      nature of the educational investment in India and the nature of the stay in
      Australia. This new information base could possibly lay the groundwork for more
      restrictive policies to be introduced both in Australia and India.
FAU - Balasubramanian, Madhan
AU  - Balasubramanian M
AD  - Research Officer, Australian Research Centre for Population Oral Health, School
      of Dentistry, The University of Adelaide, South Australia, Gopakumar, Australia. 
      madhan.balasubramanian@adelaide.edu.ac
FAU - Short, Stephanie D
AU  - Short SD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - India
TA  - Indian J Dent Res
JT  - Indian journal of dental research : official publication of Indian Society for
      Dental Research
JID - 9202990
MH  - Australia
MH  - Communication
MH  - Conflict, Psychological
MH  - Dental Care
MH  - Dentists/*ethics/supply & distribution
MH  - Education, Dental
MH  - *Emigration and Immigration
MH  - *Ethics, Dental
MH  - Foreign Professional Personnel
MH  - Health Services Needs and Demand
MH  - Humans
MH  - India
MH  - *International Cooperation
MH  - Negotiating
MH  - Public Policy
MH  - Social Environment
EDAT- 2012/04/10 06:00
MHDA- 2012/09/26 06:00
CRDT- 2012/04/10 06:00
PHST- 2012/04/10 06:00 [entrez]
PHST- 2012/04/10 06:00 [pubmed]
PHST- 2012/09/26 06:00 [medline]
AID - IndianJDentRes_2011_22_6_866_94689 [pii]
AID - 10.4103/0970-9290.94689 [doi]
PST - ppublish
SO  - Indian J Dent Res. 2011 Nov-Dec;22(6):866-8. doi: 10.4103/0970-9290.94689.


PMID- 22479861
OWN - NLM
STAT- MEDLINE
DCOM- 20120423
LR  - 20191210
IS  - 0026-2102 (Print)
IS  - 0026-2102 (Linking)
VI  - 93
IP  - 12
DP  - 2011 Dec
TI  - Internet coupons and professional ethics.
PG  - 22
FAU - Maihofer, Michael
AU  - Maihofer M
AD  - MDA Committee on Peer Review/Ethics, USA. mgmdds@wideopenwest.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Mich Dent Assoc
JT  - The Journal of the Michigan Dental Association
JID - 7505621
MH  - Advertising/economics/*ethics
MH  - Codes of Ethics
MH  - *Ethics, Dental
MH  - Fees, Dental/*ethics
MH  - Humans
MH  - Insurance, Dental
MH  - *Internet
MH  - Marketing of Health Services/*ethics
MH  - Michigan
EDAT- 2012/04/07 06:00
MHDA- 2012/04/24 06:00
CRDT- 2012/04/07 06:00
PHST- 2012/04/07 06:00 [entrez]
PHST- 2012/04/07 06:00 [pubmed]
PHST- 2012/04/24 06:00 [medline]
PST - ppublish
SO  - J Mich Dent Assoc. 2011 Dec;93(12):22.


PMID- 22473950
OWN - NLM
STAT- MEDLINE
DCOM- 20121004
LR  - 20201209
IS  - 1468-3148 (Electronic)
IS  - 1360-2322 (Linking)
VI  - 25
IP  - 1
DP  - 2012 Jan
TI  - Subjective quality of life of women with intellectual disabilities: the role of
      perceived control over their own life in self-determined behaviour.
PG  - 71-9
LID - 10.1111/j.1468-3148.2011.00646.x [doi]
AB  - BACKGROUND: Quality of life for people with intellectual disabilities has been
      reported in the research literature across differing demographics. There has
      been, however, little research that has examined in-depth the experiences of
      women with intellectual disabilities aged 40 years or older. MATERIALS AND
      METHODS: Fifty-five women from Sydney, Australia, and Prague, Czech Republic,
      were recruited to the study. Participants were recruited through agencies known
      to the researchers, ensuring ethical conduct of all procedures. RESULTS: Each
      participant completed a semi-structured interview, and using a grounded theory
      approach, a series of themes were identified common across all women. The
      strongest theme identified throughout the interviews was the lack of control
      participants perceived they had over their lives. CONCLUSIONS: The results of
      this study further the call for people with intellectual disabilities to be
      provided the opportunity to participate in decisions about their life choices.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Strnadova, Iva
AU  - Strnadova I
AD  - School of Education, Faculty of Arts and Social Sciences, University of New South
      Wales, NSW, Australia.
FAU - Evans, David
AU  - Evans D
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110909
PL  - England
TA  - J Appl Res Intellect Disabil
JT  - Journal of applied research in intellectual disabilities : JARID
JID - 9613616
SB  - IM
MH  - Adult
MH  - Aged
MH  - Australia
MH  - Cross-Cultural Comparison
MH  - Czech Republic
MH  - Female
MH  - Humans
MH  - Interview, Psychological
MH  - Middle Aged
MH  - *Personal Autonomy
MH  - Persons with Mental Disabilities/*psychology
MH  - Qualitative Research
MH  - *Quality of Life
EDAT- 2012/04/05 06:00
MHDA- 2012/10/05 06:00
CRDT- 2012/04/05 06:00
PHST- 2012/04/05 06:00 [entrez]
PHST- 2012/04/05 06:00 [pubmed]
PHST- 2012/10/05 06:00 [medline]
AID - 10.1111/j.1468-3148.2011.00646.x [doi]
PST - ppublish
SO  - J Appl Res Intellect Disabil. 2012 Jan;25(1):71-9. doi:
      10.1111/j.1468-3148.2011.00646.x. Epub 2011 Sep 9.


PMID- 22469020
OWN - NLM
STAT- MEDLINE
DCOM- 20120807
LR  - 20220318
IS  - 1049-023X (Print)
IS  - 1049-023X (Linking)
VI  - 26
IP  - 6
DP  - 2011 Dec
TI  - A qualitative and quantitative study of the surgical and rehabilitation response 
      to the earthquake in Haiti, January 2010.
PG  - 449-56
LID - 10.1017/S1049023X12000088 [doi]
AB  - BACKGROUND: The disaster response environment in Haiti following the 2010
      earthquake represented a complex healthcare challenge. This study was designed to
      identify challenges during the Haiti disaster response. METHODS: Qualitative and 
      quantitative study of injured patients carried out six months after the January
      2010 earthquake in Haiti to review the surgical inputs of foreign medical teams. 
      RESULTS: Study findings revealed a need during the response for improved medical 
      records and data gathering for regulation, quality assurance, coordination and
      resource allocation; wider adherence to standard patient referral mechanisms and 
      protocols linking surgical service provision with appropriate hospital and
      community based rehabilitation services; a greater recognition of the impact of
      non-amputation injury, and the need for patients to have a greater say in their
      management and to be the keepers of their medical records. Key first steps to
      improving the international response are a minimum dataset and uniform reporting.
      CONCLUSION: This study showed that challenges for emergency medical response
      during the Haiti Earthquake involved issues of accountability, professional
      ethics, standards-of-care, unmet needs, patient agency and expected outcomes for 
      patients in such settings:
FAU - Redmond, Anthony D
AU  - Redmond AD
AD  - Humanitarian and Conflict Response Institute, University of Manchester, UK.
      tony.redmond@manchester.ac.uk
FAU - Mardel, Simon
AU  - Mardel S
FAU - Taithe, Bertrand
AU  - Taithe B
FAU - Calvot, Thomas
AU  - Calvot T
FAU - Gosney, Jim
AU  - Gosney J
FAU - Duttine, Antony
AU  - Duttine A
FAU - Girois, Susan
AU  - Girois S
LA  - eng
PT  - Journal Article
DEP - 20120402
PL  - United States
TA  - Prehosp Disaster Med
JT  - Prehospital and disaster medicine
JID - 8918173
MH  - Amputation/statistics & numerical data
MH  - Amputees/rehabilitation
MH  - Disaster Planning
MH  - *Earthquakes/statistics & numerical data
MH  - Emergency Medical Services
MH  - Haiti
MH  - Health Services Needs and Demand
MH  - Humans
MH  - Needs Assessment
MH  - Surgical Procedures, Operative/*statistics & numerical data
EDAT- 2012/04/04 06:00
MHDA- 2012/08/08 06:00
CRDT- 2012/04/04 06:00
PHST- 2012/04/04 06:00 [entrez]
PHST- 2012/04/04 06:00 [pubmed]
PHST- 2012/08/08 06:00 [medline]
AID - S1049023X12000088 [pii]
AID - 10.1017/S1049023X12000088 [doi]
PST - ppublish
SO  - Prehosp Disaster Med. 2011 Dec;26(6):449-56. doi: 10.1017/S1049023X12000088. Epub
      2012 Apr 2.


PMID- 22468380
OWN - NLM
STAT- MEDLINE
DCOM- 20120425
LR  - 20181201
IS  - 0023-7205 (Print)
IS  - 0023-7205 (Linking)
VI  - 108
IP  - 46
DP  - 2011 Nov 16-22
TI  - ["...the knowledge of being able to live a life richer than most". About Clarence
      Blomquist--pioneer of medical ethics in Sweden].
PG  - 2385-7
FAU - Halldin, Jan
AU  - Halldin J
AD  - jan.halldin@gmail.com
LA  - swe
PT  - Biography
PT  - Historical Article
PT  - Journal Article
PT  - Portrait
TT  - "... Vissheten av att ha fatt leva ett liv langt rikare an de flesta" Om Clarence
      Blomquist - medicinetikens pionjar i Sverige.
PL  - Sweden
TA  - Lakartidningen
JT  - Lakartidningen
JID - 0027707
SB  - IM
MH  - Ethics, Medical/*history
MH  - History, 20th Century
MH  - Humans
MH  - Michigan
MH  - Physicians/*history
MH  - Sweden
PS  - Blomquist C
FPS - Blomquist, Clarence
EDAT- 2012/04/04 06:00
MHDA- 2012/04/26 06:00
CRDT- 2012/04/04 06:00
PHST- 2012/04/04 06:00 [entrez]
PHST- 2012/04/04 06:00 [pubmed]
PHST- 2012/04/26 06:00 [medline]
PST - ppublish
SO  - Lakartidningen. 2011 Nov 16-22;108(46):2385-7.


PMID- 22468379
OWN - NLM
STAT- MEDLINE
DCOM- 20120425
LR  - 20151119
IS  - 0023-7205 (Print)
IS  - 0023-7205 (Linking)
VI  - 108
IP  - 46
DP  - 2011 Nov 16-22
TI  - [GlaxoSmithKline requires additional consideration of the national procurement of
      cancer vaccine: Procurement of HPV vaccine is not consistent with good
      scientific, ethical and moral practice].
PG  - 2383
FAU - Thor, Johan
AU  - Thor J
AD  - GlaxoSmithKline AB. johan.o.thor@gsk.com
FAU - Flaten, Olav
AU  - Flaten O
LA  - swe
PT  - Journal Article
TT  - GlaxoSmithKline begar overprovning av nationell upphandling av cancervaccin:
      Upphandling av HPV-vaccin inte forenlig med god vetenskap, etik och moral.
PL  - Sweden
TA  - Lakartidningen
JT  - Lakartidningen
JID - 0027707
RN  - 0 (Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18)
RN  - 0 (Papillomavirus Vaccines)
RN  - 0 (human papillomavirus vaccine, L1 type 16, 18)
SB  - IM
MH  - Decision Making
MH  - *Drug Industry
MH  - *Group Purchasing
MH  - Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18
MH  - Humans
MH  - *Papillomavirus Vaccines/supply & distribution
MH  - Physician's Role
MH  - Public-Private Sector Partnerships
MH  - Sweden
EDAT- 2012/04/04 06:00
MHDA- 2012/04/26 06:00
CRDT- 2012/04/04 06:00
PHST- 2012/04/04 06:00 [entrez]
PHST- 2012/04/04 06:00 [pubmed]
PHST- 2012/04/26 06:00 [medline]
PST - ppublish
SO  - Lakartidningen. 2011 Nov 16-22;108(46):2383.


PMID- 22468245
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 0973-7707 (Electronic)
IS  - 2231-3796 (Linking)
VI  - 63
IP  - 2
DP  - 2011 Apr
TI  - A Single Blinded Randomized Controlled Study of the Effect of Conventional Oral
      Hypoglycemic Agents Versus Intensive Short-Term Insulin Therapy on Pure Tone
      Audiometry in Type II Diabetes Mellitus.
PG  - 114-8
LID - 10.1007/s12070-011-0132-y [doi]
AB  - Neuropathy is frequently a late complication of diabetes mellitus. Auditory
      neuropathy and microangiopathy of inner ear are the possible causes of hearing
      loss in diabetics. To study the correlation between glycaemic control and hearing
      threshold in patients with type 2 diabetes mellitus and to determine the
      differences of hearing threshold between groups treated with different modality. 
      This single blind randomized controlled study was performed at the Department of 
      Medicine and Department of Otorhinolaryngology, Hospital Universiti Kebangsaan
      Malaysia (UKM) between 1st May 2003 and 31st September 2004. This study was
      approved by Research Ethics Committee (code number FF-137). Subjects were
      randomized into two groups. Group 1 were patients treated with conventional oral 
      hypoglycemic agents. The patients in group 2 were those treated with insulin
      injection. The subjects were seen 4 weekly for 3 months. Audiometric test were
      performed in all subjects at each visit. Blood were taken for fasting blood
      glucose, Hb1Ac, and fructosamine at every visit to determine the glycaemic
      controls of the subject. They were 11 patients (22 ears) treated with oral
      hypoglycemic agents and 17 patients treated (34 ears) with subcutaneous insulin. 
      There is no significant difference between mean pure tone threshold before and
      after treatment at all frequencies in both groups. There is also no significance 
      different in fasting glucose level and fructosamine. However, there is
      significant difference HbA1c levels between the two groups after treatment (P <
      0.05). This study has shown that glycaemic control does not have significant
      impact on hearing. The hearing threshold is neither affected by insulin treatment
      nor by the glycaemic control.
FAU - Asma, A
AU  - Asma A
FAU - Azmi, M Nor
AU  - Azmi MN
FAU - Mazita, A
AU  - Mazita A
FAU - Marina, M B
AU  - Marina MB
FAU - Salina, H
AU  - Salina H
FAU - Norlaila, M
AU  - Norlaila M
LA  - eng
PT  - Journal Article
DEP - 20110208
PL  - India
TA  - Indian J Otolaryngol Head Neck Surg
JT  - Indian journal of otolaryngology and head and neck surgery : official publication
      of the Association of Otolaryngologists of India
JID - 9422551
PMC - PMC3102159
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - Fructosamine
OT  - Glycemic control
OT  - Hearing loss
OT  - Insulin
EDAT- 2012/04/03 06:00
MHDA- 2012/04/03 06:01
CRDT- 2012/04/03 06:00
PHST- 2010/03/09 00:00 [received]
PHST- 2010/06/13 00:00 [accepted]
PHST- 2012/04/03 06:00 [entrez]
PHST- 2012/04/03 06:00 [pubmed]
PHST- 2012/04/03 06:01 [medline]
AID - 10.1007/s12070-011-0132-y [doi]
AID - 132 [pii]
PST - ppublish
SO  - Indian J Otolaryngol Head Neck Surg. 2011 Apr;63(2):114-8. doi:
      10.1007/s12070-011-0132-y. Epub 2011 Feb 8.


PMID- 22468129
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1918-1485 (Electronic)
IS  - 1205-7088 (Linking)
VI  - 16
IP  - 4
DP  - 2011 Apr
TI  - Withholding and withdrawing artificial nutrition and hydration.
PG  - 241-4
AB  - Although the practice of withholding and withdrawing artificial nutrition and
      hydration (ANH) has become more common, it remains controversial, particularly in
      the paediatric setting. Decisions regarding ANH, along with other medical
      interventions, should be considered in the individual context of the child's
      overall plan of care. The purpose of the present practice point is to provide
      guidance for Canadian paediatric health care practitioners regarding when
      withholding or withdrawing ANH may be an ethically permissible option as part of 
      a palliative care plan and to briefly address some pragmatic considerations.
FAU - Tsai, E
AU  - Tsai E
LA  - eng
LA  - fre
PT  - Journal Article
PL  - England
TA  - Paediatr Child Health
JT  - Paediatrics & child health
JID - 9815960
PMC - PMC3076180
OTO - NOTNLM
OT  - Artificial nutrition and hydration
OT  - Ethics
OT  - Paediatric end-of-life care
OT  - Palliative care
EDAT- 2012/04/03 06:00
MHDA- 2012/04/03 06:01
CRDT- 2012/04/03 06:00
PHST- 2012/04/03 06:00 [entrez]
PHST- 2012/04/03 06:00 [pubmed]
PHST- 2012/04/03 06:01 [medline]
AID - 10.1093/pch/16.4.241 [doi]
PST - ppublish
SO  - Paediatr Child Health. 2011 Apr;16(4):241-4. doi: 10.1093/pch/16.4.241.


PMID- 22468127
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1918-1485 (Electronic)
IS  - 1205-7088 (Linking)
VI  - 16
IP  - 4
DP  - 2011 Apr
TI  - Ethical participation of children and youth in medical education.
PG  - 223-32
AB  - Children and youth (referred to as 'children' in the present statement), whether 
      actual patients or volunteers, frequently participate in medical education. The
      present position statement discusses the numerous ethical challenges that may
      arise including respect for persons, truth telling and confidentiality. The
      statement provides guidelines that may be helpful to educators from a wide
      variety of disciplines.
FAU - Hilliard, Ri
AU  - Hilliard R
FAU - Fernandez, Cv
AU  - Fernandez C
FAU - Tsai, E
AU  - Tsai E
LA  - eng
LA  - fre
PT  - Journal Article
PL  - England
TA  - Paediatr Child Health
JT  - Paediatrics & child health
JID - 9815960
PMC - PMC3076176
OTO - NOTNLM
OT  - Children and youth
OT  - Ethics
OT  - Medical education
OT  - Paediatric patients
OT  - Respect for patients
OT  - Truth telling
EDAT- 2012/04/03 06:00
MHDA- 2012/04/03 06:01
CRDT- 2012/04/03 06:00
PHST- 2012/04/03 06:00 [entrez]
PHST- 2012/04/03 06:00 [pubmed]
PHST- 2012/04/03 06:01 [medline]
AID - 10.1093/pch/16.4.223 [doi]
PST - ppublish
SO  - Paediatr Child Health. 2011 Apr;16(4):223-32. doi: 10.1093/pch/16.4.223.


PMID- 22467960
OWN - NLM
STAT- MEDLINE
DCOM- 20120627
LR  - 20211021
IS  - 0008-5286 (Print)
IS  - 0008-5286 (Linking)
VI  - 52
IP  - 10
DP  - 2011 Oct
TI  - An ethicist's commentary on licensing boards dictating therapies.
PG  - 1048-50
FAU - Rollin, Bernard E
AU  - Rollin BE
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Vet J
JT  - The Canadian veterinary journal = La revue veterinaire canadienne
JID - 0004653
SB  - IM
CIN - Can Vet J. 2011 Dec;52(12):1276. PMID: 22654130
CIN - Can Vet J. 2012 Jan;53(1):9. PMID: 22753956
MH  - Animals
MH  - Canada
MH  - Costs and Cost Analysis
MH  - Humans
MH  - *Legislation, Veterinary
MH  - Licensure/*ethics
MH  - Veterinary Medicine/economics/*ethics/*methods
PMC - PMC3174500
EDAT- 2012/04/03 06:00
MHDA- 2012/06/28 06:00
CRDT- 2012/04/03 06:00
PHST- 2012/04/03 06:00 [entrez]
PHST- 2012/04/03 06:00 [pubmed]
PHST- 2012/06/28 06:00 [medline]
PST - ppublish
SO  - Can Vet J. 2011 Oct;52(10):1048-50.


PMID- 22460503
OWN - NLM
STAT- MEDLINE
DCOM- 20120810
LR  - 20190911
IS  - 1984-0446 (Electronic)
IS  - 0034-7167 (Linking)
VI  - 64
IP  - 5
DP  - 2011 Sep-Oct
TI  - [Training of community health workers: experience of teaching and practice with
      nursing students].
PG  - 968-73
LID - S0034-71672011000500026 [pii]
AB  - This paper aims to report an experience carried out by nursing students from the 
      Undergraduate School of Health Sciences, Federal District, during their first
      year of study. The objective was to implement a training for 22 community health 
      workers, in order to clarify them about their role in community work and to
      elevate their self esteem. A methodology of problematization and various
      educational techniques were used. The themes were: duties and rights,
      responsibilities, communication, ethics, team work, children s health, care for
      the elderly and domestic violence. The result was considered positive for both
      sides: the community workers acquired new knowledge/capabilities and better
      feeling of self worth and the students were able to integrate theory and practice
      and become active participants in the learning process.
FAU - Cardoso, Fatima Aparecida
AU  - Cardoso FA
AD  - Fundacao de Ensino e Pesquisa em Ciencias da Saude, Escola Superior de Ciencias
      da Saude, Curso de Graduacao em Enfermagem. Brasilia-DF, Brasil.
      fafacardoso@gmail.com
FAU - Cordeiro, Vitoria Regia de Negreiros
AU  - Cordeiro VR
FAU - Lima, Daniele Barreto de
AU  - Lima DB
FAU - Melo, Barbara de Caldas
AU  - Melo Bde C
FAU - Menezes, Raquel Nobre Barreto de
AU  - Menezes RN
FAU - Moulaz, Ana Luiza Silva de
AU  - Moulaz AL
FAU - Sa, Gabrielle Boff de
AU  - Sa GB
FAU - Souza, Adalgisa Vania Fernandes de
AU  - Souza AV
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Capacitacao de agentes comunitarios de saude: experiencia de ensino e pratica com
      alunos de Enfermagem.
PL  - Brazil
TA  - Rev Bras Enferm
JT  - Revista brasileira de enfermagem
JID - 7910105
MH  - Community Health Workers/*education
MH  - Education, Nursing/*methods
MH  - *Students, Nursing
EDAT- 2012/03/31 06:00
MHDA- 2012/08/11 06:00
CRDT- 2012/03/31 06:00
PHST- 2010/12/07 00:00 [received]
PHST- 2012/01/23 00:00 [accepted]
PHST- 2012/03/31 06:00 [entrez]
PHST- 2012/03/31 06:00 [pubmed]
PHST- 2012/08/11 06:00 [medline]
AID - S0034-71672011000500026 [pii]
AID - 10.1590/s0034-71672011000500026 [doi]
PST - ppublish
SO  - Rev Bras Enferm. 2011 Sep-Oct;64(5):968-73. doi: 10.1590/s0034-71672011000500026.


PMID- 22460501
OWN - NLM
STAT- MEDLINE
DCOM- 20120810
LR  - 20190911
IS  - 1984-0446 (Electronic)
IS  - 0034-7167 (Linking)
VI  - 64
IP  - 5
DP  - 2011 Sep-Oct
TI  - [Reflections on the care of nursing and the autonomy of the human being under the
      condition of hospitalized elderly].
PG  - 958-62
LID - S0034-71672011000500024 [pii]
AB  - There has been an increase of chronic diseases with the subsequent need for care 
      and hospitalization, due to the acceleration of the elderly demographic growth.
      The objective of the present paper is to reflect on the care of nursing and the
      autonomy of the human being under the condition of elderly hospitalization.
      Nursing professionals, caring in the hospital ambient, can contribute
      significantly for the construction of the elderly autonomy and participation on
      the decision making about their need for attention or health care. The ethics
      redeeming, under a worthy aging perspective, permeates several discussions in the
      aging society and, specifically, among health professionals who act in hospital
      institutions.
FAU - Carretta, Marisa Basegio
AU  - Carretta MB
AD  - Universidade de Passo Fundo, Passo Fundo, RS, Brasil. marisa.basegio@yahoo.com.br
FAU - Bettinelli, Luiz Antonio
AU  - Bettinelli LA
FAU - Erdmann, Alacoque Lorenzini
AU  - Erdmann AL
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Reflexoes sobre o cuidado de enfermagem e a autonomia do ser humano na condicao
      de idoso hospitalizado.
PL  - Brazil
TA  - Rev Bras Enferm
JT  - Revista brasileira de enfermagem
JID - 7910105
MH  - Aged
MH  - *Geriatric Nursing
MH  - *Hospitalization
MH  - Humans
MH  - *Personal Autonomy
EDAT- 2012/03/31 06:00
MHDA- 2012/08/11 06:00
CRDT- 2012/03/31 06:00
PHST- 2010/01/15 00:00 [received]
PHST- 2011/12/13 00:00 [accepted]
PHST- 2012/03/31 06:00 [entrez]
PHST- 2012/03/31 06:00 [pubmed]
PHST- 2012/08/11 06:00 [medline]
AID - S0034-71672011000500024 [pii]
AID - 10.1590/s0034-71672011000500024 [doi]
PST - ppublish
SO  - Rev Bras Enferm. 2011 Sep-Oct;64(5):958-62. doi: 10.1590/s0034-71672011000500024.


PMID- 22460500
OWN - NLM
STAT- MEDLINE
DCOM- 20120810
LR  - 20190911
IS  - 1984-0446 (Electronic)
IS  - 0034-7167 (Linking)
VI  - 64
IP  - 5
DP  - 2011 Sep-Oct
TI  - [Public policy and rights of Single Health System's users with diabetes
      mellitus].
PG  - 952-7
LID - S0034-71672011000500023 [pii]
AB  - This study approaches the relationship between public policies and the rights of 
      SUS (Single Health System) users with diabetes mellitus regarding the supplies
      used in the treatment of diabetes, under the view of legal rules and procedures
      for support of this population. Health professionals should be a link between
      users and current health model, actively assuming a role of defending the rights 
      of SUS users with diabetes mellitus. This posture is an ideal to be achieved and 
      consolidated in daily practices. The educational process needs to be
      strengthened, including the ethical-political dimension during actions
      implemented with SUS users.
FAU - Santos, Ellen Cristina Barbosa dos
AU  - Santos EC
AD  - Escola de Enfermagem de Ribeirao Preto, Departamento de Enfermagem Geral e
      Especializada, Universidade de Sao Paulo, Ribeirao Preto-SP, Brasil.
      ellenbarbosa@usp.br
FAU - Teixeira, Carla Regina de Souza
AU  - Teixeira CR
FAU - Zanetti, Maria Lucia
AU  - Zanetti ML
FAU - Santos, Manoel Antonio dos
AU  - Santos MA
FAU - Pereira, Marta Cristiane Alves
AU  - Pereira MC
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Politicas publicas e direitos dos usuarios do Sistema Unico de Saude com diabetes
      mellitus.
PL  - Brazil
TA  - Rev Bras Enferm
JT  - Revista brasileira de enfermagem
JID - 7910105
MH  - Brazil
MH  - *Delivery of Health Care
MH  - *Diabetes Mellitus/therapy
MH  - Humans
MH  - *Patient Rights
MH  - *Public Policy
EDAT- 2012/03/31 06:00
MHDA- 2012/08/11 06:00
CRDT- 2012/03/31 06:00
PHST- 2009/08/04 00:00 [received]
PHST- 2011/09/05 00:00 [accepted]
PHST- 2012/03/31 06:00 [entrez]
PHST- 2012/03/31 06:00 [pubmed]
PHST- 2012/08/11 06:00 [medline]
AID - S0034-71672011000500023 [pii]
AID - 10.1590/s0034-71672011000500023 [doi]
PST - ppublish
SO  - Rev Bras Enferm. 2011 Sep-Oct;64(5):952-7. doi: 10.1590/s0034-71672011000500023.


PMID- 22458021
OWN - NLM
STAT- MEDLINE
DCOM- 20120719
LR  - 20120330
IS  - 0021-4892 (Print)
IS  - 0021-4892 (Linking)
VI  - 60 Suppl
DP  - 2011 Nov
TI  - [Transition and problems of ethical guidelines for medical research in Japan].
PG  - S37-44
FAU - Kosugi, Shinji
AU  - Kosugi S
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Masui
JT  - Masui. The Japanese journal of anesthesiology
JID - 0413707
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Clinical Trials as Topic/ethics
MH  - Epidemiology/ethics
MH  - Ethics Committees
MH  - *Guidelines as Topic
MH  - Human Genome Project/ethics
MH  - Humans
MH  - Japan
EDAT- 2012/03/31 06:00
MHDA- 2012/07/20 06:00
CRDT- 2012/03/31 06:00
PHST- 2012/03/31 06:00 [entrez]
PHST- 2012/03/31 06:00 [pubmed]
PHST- 2012/07/20 06:00 [medline]
PST - ppublish
SO  - Masui. 2011 Nov;60 Suppl:S37-44.


PMID- 22454989
OWN - NLM
STAT- MEDLINE
DCOM- 20120412
LR  - 20120328
IS  - 0546-1766 (Print)
IS  - 0546-1766 (Linking)
VI  - 58
IP  - 10
DP  - 2011 Oct
TI  - [Public health for scientific study of society and health (11). Keypoints in
      ethical guidelines for medical research].
PG  - 909-12
FAU - Kobayashi, Shinji
AU  - Kobayashi S
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Nihon Koshu Eisei Zasshi
JT  - [Nihon koshu eisei zasshi] Japanese journal of public health
JID - 19130150R
SB  - IM
MH  - *Ethics, Medical
MH  - *Guidelines as Topic
MH  - Research/*standards
EDAT- 2012/03/30 06:00
MHDA- 2012/04/13 06:00
CRDT- 2012/03/30 06:00
PHST- 2012/03/30 06:00 [entrez]
PHST- 2012/03/30 06:00 [pubmed]
PHST- 2012/04/13 06:00 [medline]
PST - ppublish
SO  - Nihon Koshu Eisei Zasshi. 2011 Oct;58(10):909-12.


PMID- 22440783
OWN - NLM
STAT- MEDLINE
DCOM- 20120823
LR  - 20160520
IS  - 1879-6265 (Electronic)
IS  - 1879-6257 (Linking)
VI  - 1
IP  - 4
DP  - 2011 Oct
TI  - Ethics of vaccination programs.
PG  - 263-7
LID - 10.1016/j.coviro.2011.05.009 [doi]
AB  - Ethical issues are present at each stage in the vaccine product life cycle, the
      period extending from the earliest stages of research through the eventual design
      and implementation of global vaccination programs. Recent developments highlight 
      fundamental principles of vaccine ethics and raise unique issues for ongoing
      vaccination activities worldwide. These include the 2009-10 H1N1 pandemic
      influenza vaccination campaign, renewed attention to the potential global
      eradication of polio, and the ongoing evaluation of vaccine risk controversies,
      most notably the alleged link between childhood vaccines and autism. These cases 
      present ethical challenges for public health policy-makers, scientists,
      physicians, and other stakeholders in their efforts to improve the health of
      individuals, communities, and nations through vaccination.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Schwartz, Jason L
AU  - Schwartz JL
AD  - Center for Bioethics, Department of History and Sociology of Science, University 
      of Pennsylvania, 3401 Market Street, Suite 320, Philadelphia, PA 19104, USA.
      JLSCHWA2@mail.med.upenn.edu
FAU - Caplan, Arthur L
AU  - Caplan AL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110616
PL  - Netherlands
TA  - Curr Opin Virol
JT  - Current opinion in virology
JID - 101560941
RN  - 0 (Influenza Vaccines)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Immunization Programs/*ethics
MH  - Influenza Vaccines/administration & dosage/adverse effects/immunology
MH  - Influenza, Human/immunology/prevention & control/virology
MH  - Vaccination/adverse effects/*ethics
MH  - Viral Vaccines/administration & dosage/adverse effects/immunology
MH  - Virus Diseases/immunology/*prevention & control/virology
EDAT- 2012/03/24 06:00
MHDA- 2012/08/24 06:00
CRDT- 2012/03/24 06:00
PHST- 2011/04/26 00:00 [received]
PHST- 2011/05/13 00:00 [accepted]
PHST- 2012/03/24 06:00 [entrez]
PHST- 2012/03/24 06:00 [pubmed]
PHST- 2012/08/24 06:00 [medline]
AID - S1879-6257(11)00014-9 [pii]
AID - 10.1016/j.coviro.2011.05.009 [doi]
PST - ppublish
SO  - Curr Opin Virol. 2011 Oct;1(4):263-7. doi: 10.1016/j.coviro.2011.05.009. Epub
      2011 Jun 16.


PMID- 22440106
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20120323
IS  - 1751-732X (Electronic)
IS  - 1751-7311 (Linking)
VI  - 5
IP  - 7
DP  - 2011 May
TI  - Consumer response to the possible use of a vaccine method to control boar taint
      v. physical piglet castration with anaesthesia: a quantitative study in four
      European countries.
PG  - 1107-18
LID - 10.1017/S1751731111000139 [doi]
AB  - In most European countries, male piglets being reared for meat are physically
      castrated without anaesthesia in order to avoid boar taint and to safeguard
      sensory meat quality. This method is increasingly criticised for its violation of
      piglet welfare. Alternative methods are being researched and castration with
      anaesthesia or analgesia and vaccination (immunisation) against
      gonadotropin-releasing hormone (using Improvac(R), Pfizer GmbH) have been
      proposed as possible solutions. In addition to efficacy, the successful
      introduction and adoption of the vaccine method by stakeholders in pig supply
      chains are expected to depend on a favourable reception by consumers. This
      large-scale quantitative cross-country study (n = 4031) involving representative 
      samples of consumers in France, Germany, the Netherlands and Belgium does not
      support the reserved attitude of stakeholders who fear potential low market
      acceptance. The vaccine method was actually preferred by the majority of
      consumers surveyed (69.6% of the participants) and it was perceived as equally
      effective in terms of avoiding boar taint; 43.8% of the consumers reported an
      intention to seek out pork from pigs where the vaccine had been used to control
      boar taint, whereas 33.7% reported an intention to avoid pork from pigs
      physically castrated with anaesthesia. Consumers' favourable dispositions to the 
      vaccine method were independent of dominant ethical, health or price orientations
      when purchasing pork.
FAU - Vanhonacker, F
AU  - Vanhonacker F
AD  - Department of Agricultural Economics, Ghent University, Coupure links 653, B-9000
      Ghent, Belgium.
FAU - Verbeke, W
AU  - Verbeke W
LA  - eng
PT  - Journal Article
PL  - England
TA  - Animal
JT  - Animal : an international journal of animal bioscience
JID - 101303270
EDAT- 2012/03/24 06:00
MHDA- 2012/03/24 06:01
CRDT- 2012/03/24 06:00
PHST- 2012/03/24 06:00 [entrez]
PHST- 2012/03/24 06:00 [pubmed]
PHST- 2012/03/24 06:01 [medline]
AID - S1751731111000139 [pii]
AID - 10.1017/S1751731111000139 [doi]
PST - ppublish
SO  - Animal. 2011 May;5(7):1107-18. doi: 10.1017/S1751731111000139.


PMID- 22428369
OWN - NLM
STAT- MEDLINE
DCOM- 20120703
LR  - 20191112
IS  - 0278-9671 (Print)
IS  - 0278-9671 (Linking)
VI  - 29
IP  - 2
DP  - 2011 Fall
TI  - Positive wrongdoings: reading doctors' narratives on ordinary ethics.
PG  - 325-54
FAU - Avrahami, Einat
AU  - Avrahami E
AD  - Department of English, Tel Aviv University.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Lit Med
JT  - Literature and medicine
JID - 8309346
SB  - IM
MH  - Confidentiality
MH  - Education, Medical
MH  - *Ethics, Medical
MH  - Humans
MH  - *Literature, Modern
MH  - *Medicine in Literature
MH  - *Morals
MH  - *Narration
MH  - Physician's Role/*psychology
MH  - Physician-Patient Relations
EDAT- 2012/03/21 06:00
MHDA- 2012/07/04 06:00
CRDT- 2012/03/21 06:00
PHST- 2012/03/21 06:00 [entrez]
PHST- 2012/03/21 06:00 [pubmed]
PHST- 2012/07/04 06:00 [medline]
AID - 10.1353/lm.2011.0327 [doi]
PST - ppublish
SO  - Lit Med. 2011 Fall;29(2):325-54. doi: 10.1353/lm.2011.0327.


PMID- 22428367
OWN - NLM
STAT- MEDLINE
DCOM- 20120703
LR  - 20191112
IS  - 0278-9671 (Print)
IS  - 0278-9671 (Linking)
VI  - 29
IP  - 2
DP  - 2011 Fall
TI  - Narrative medicine in the literature classroom: ethical pedagogy and Mark
      Haddon's The curious incident of the dog in the night-time.
PG  - 274-96
FAU - Wooden, Shannon R
AU  - Wooden SR
AD  - Missouri State University, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Lit Med
JT  - Literature and medicine
JID - 8309346
SB  - IM
MH  - Adolescent
MH  - Animals
MH  - Aptitude
MH  - Child
MH  - Child Development Disorders, Pervasive/*psychology
MH  - Curriculum
MH  - Dogs
MH  - *Education, Medical
MH  - Empathy
MH  - Ethics, Medical
MH  - Humans
MH  - *Literature, Modern
MH  - Male
MH  - *Medicine in Literature
MH  - *Narration
MH  - Parent-Child Relations
MH  - Physician-Patient Relations
MH  - Resilience, Psychological
MH  - Social Stigma
EDAT- 2012/03/21 06:00
MHDA- 2012/07/04 06:00
CRDT- 2012/03/21 06:00
PHST- 2012/03/21 06:00 [entrez]
PHST- 2012/03/21 06:00 [pubmed]
PHST- 2012/07/04 06:00 [medline]
AID - 10.1353/lm.2011.0325 [doi]
PST - ppublish
SO  - Lit Med. 2011 Fall;29(2):274-96. doi: 10.1353/lm.2011.0325.


PMID- 22428210
OWN - NLM
STAT- MEDLINE
DCOM- 20120424
LR  - 20151119
IS  - 0017-7768 (Print)
IS  - 0017-7768 (Linking)
VI  - 150
IP  - 11
DP  - 2011 Nov
TI  - [Non-indicated cesarean section--does the "Golem" counteract?].
PG  - 866-9, 874
AB  - Cesarean section rate is steadily increasing and in Israel it has risen to 20%.
      MultipLe and different reasons have led to this phenomenon, among them are
      non-indicated cesarean sections. Although health care providers disagree whether 
      this development is medically, ethically and publically justified, national
      associations allow it, while respecting those obstetricians who decline to do so.
      In Israel there are some hospitals which allow non-indicated cesarean sections,
      whereas others reject them. When discussing this issue with the patients,
      documentation is advised concerning the reasons for approval or rejection of the 
      patients' request in order to avoid future complaints in the case of adverse
      outcome. Low risk vaginal delivery should be regarded as a natural process and
      not as a medical treatment and keeping balanced and reasonable decisions may help
      to contain the phenomenon and avoid a situation in which the "Golem" created by
      the medical system, counteracts.
FAU - Herman, Arie
AU  - Herman A
AD  - Israel Society of Obstetrics and Gynecology, Department of Obstetrics, Assaf
      Harofe Medical Center, Zerifin, Israel. arieh@asaf.health.gov.il
LA  - heb
PT  - English Abstract
PT  - Journal Article
PL  - Israel
TA  - Harefuah
JT  - Harefuah
JID - 0034351
SB  - IM
MH  - Cesarean Section/ethics/*statistics & numerical data
MH  - Delivery, Obstetric/ethics/*methods
MH  - Documentation
MH  - Female
MH  - Humans
MH  - Israel
MH  - Patient Participation
MH  - Practice Patterns, Physicians'/ethics/statistics & numerical data
MH  - Pregnancy
MH  - Unnecessary Procedures/ethics/*statistics & numerical data
EDAT- 2012/03/21 06:00
MHDA- 2012/04/25 06:00
CRDT- 2012/03/21 06:00
PHST- 2012/03/21 06:00 [entrez]
PHST- 2012/03/21 06:00 [pubmed]
PHST- 2012/04/25 06:00 [medline]
PST - ppublish
SO  - Harefuah. 2011 Nov;150(11):866-9, 874.


PMID- 22427700
OWN - NLM
STAT- MEDLINE
DCOM- 20120716
LR  - 20191210
IS  - 1465-735X (Electronic)
IS  - 0146-8693 (Linking)
VI  - 37
IP  - 3
DP  - 2012 Apr
TI  - Covert video monitoring in the assessment of medically unexplained symptoms in
      children.
PG  - 329-37
LID - 10.1093/jpepsy/jsr098 [doi]
AB  - OBJECTIVE: Diagnosis of medically unexplained symptoms (MUS) occurs after
      thorough evaluations have failed to identify a physiological cause for symptoms. 
      However, families and providers may wonder if something has been missed, leading 
      to reduced confidence in behavioral treatment. Confidence may be improved through
      the use of technology such as covert video monitoring to better assess
      functioning across settings. METHODS: A 12-year-old male presented with
      progressive neurological decline, precipitated by chronic pain. After thorough
      evaluation and the failure of standard treatments (medical, rehabilitative, and
      psychological) covert video monitoring revealed that the patient demonstrated
      greater abilities when alone in his room. Negative reinforcement was used to
      initiate recovery, accompanied by positive reinforcement and a rehabilitative
      approach. Covert video monitoring assisted in three subsequent cases over the
      following 3 years. RESULTS AND CONCLUSIONS: In certain complex cases, video
      monitoring can inform the assessment and treatment of MUS. Discussion includes
      ethical and practical considerations.
FAU - Wallace, Dustin P
AU  - Wallace DP
AD  - Integrative Pain Management, Children's Mercy Hospital, Kansas City, MO 64108,
      USA. dpwallace@cmh.edu
FAU - Sim, Leslie A
AU  - Sim LA
FAU - Harrison, Tracy E
AU  - Harrison TE
FAU - Bruce, Barbara K
AU  - Bruce BK
FAU - Harbeck-Weber, Cynthia
AU  - Harbeck-Weber C
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20111202
PL  - United States
TA  - J Pediatr Psychol
JT  - Journal of pediatric psychology
JID - 7801773
SB  - IM
MH  - Behavior Therapy
MH  - Child
MH  - Humans
MH  - Male
MH  - Pain/diagnosis/psychology
MH  - Pain Management
MH  - Reinforcement, Psychology
MH  - Somatoform Disorders/*diagnosis/psychology/therapy
MH  - *Video Recording
EDAT- 2012/03/20 06:00
MHDA- 2012/07/17 06:00
CRDT- 2012/03/20 06:00
PHST- 2012/03/20 06:00 [entrez]
PHST- 2012/03/20 06:00 [pubmed]
PHST- 2012/07/17 06:00 [medline]
AID - jsr098 [pii]
AID - 10.1093/jpepsy/jsr098 [doi]
PST - ppublish
SO  - J Pediatr Psychol. 2012 Apr;37(3):329-37. doi: 10.1093/jpepsy/jsr098. Epub 2011
      Dec 2.


PMID- 22422781
OWN - NLM
STAT- MEDLINE
DCOM- 20120619
LR  - 20161125
IS  - 0025-8024 (Print)
IS  - 0025-8024 (Linking)
VI  - 52
IP  - 2
DP  - 2012 Apr
TI  - The second professional and detention renewal: an exploration of a generic
      statutory role.
PG  - 75-80
LID - 10.1258/msl.2011.011063 [doi]
AB  - The amended Mental Health Act of 2007 introduced the generic statutory role of
      the second professional in the renewal of authority for detention, with the
      purpose of providing an additional safeguard for patients. Completed detention
      renewals from a National Health Service (NHS) Trust were systematically collected
      over 12 months (n = 47). Second professionals identified on Form H5 were
      requested to return a questionnaire designed to explore the role and the
      eligibility, knowledge base and attitudes of those fulfilling it, in comparison
      to the requirements as described in the code of practice and in relation to the
      stated purpose of the role. Twenty-eight second professionals completed
      questionnaires, giving a response rate of 60%. Several factors were identified
      which appeared to conspire against the notion that the aim of the role had been
      achieved in a meaningful way. The reasons underlying this included tokenistic
      statutory paperwork and a clear lack of specific training. Training needs
      identified included increasing legal knowledge and raising awareness of the
      ethical issues associated with a statutory role with a responsible nature. The
      findings challenge the assumption of readiness in those being asked to act in the
      generic statutory role of the second professional and highlight the potential for
      difficulties in the process of moving towards a cultural change of distributed
      responsibility in psychiatry, both in terms of the introduction of generic
      statutory roles in the absence of training and also with relevance to the
      changing nature of traditionally defined professional roles as suggested by new
      ways of working.
FAU - Brunskill, David
AU  - Brunskill D
AD  - Devon Partnership NHS Trust - Forensic Psychiatric Services, Langdon Hospital,
      Devon, UK. david.brunskill@nhs.net
FAU - Dorkins, Eluned
AU  - Dorkins E
LA  - eng
PT  - Journal Article
DEP - 20111130
PL  - England
TA  - Med Sci Law
JT  - Medicine, science, and the law
JID - 0400721
SB  - IM
MH  - *Clinical Competence
MH  - Commitment of Mentally Ill/*legislation & jurisprudence
MH  - *Decision Making
MH  - Health Personnel/*statistics & numerical data
MH  - Humans
MH  - Mental Health Services/legislation & jurisprudence
MH  - Surveys and Questionnaires
MH  - United Kingdom
EDAT- 2012/03/17 06:00
MHDA- 2012/06/20 06:00
CRDT- 2012/03/17 06:00
PHST- 2012/03/17 06:00 [entrez]
PHST- 2012/03/17 06:00 [pubmed]
PHST- 2012/06/20 06:00 [medline]
AID - msl.2011.011063 [pii]
AID - 10.1258/msl.2011.011063 [doi]
PST - ppublish
SO  - Med Sci Law. 2012 Apr;52(2):75-80. doi: 10.1258/msl.2011.011063. Epub 2011 Nov
      30.


PMID- 22416566
OWN - NLM
STAT- MEDLINE
DCOM- 20120503
LR  - 20120315
IS  - 1362-3699 (Print)
IS  - 1362-3699 (Linking)
VI  - 27
IP  - 4
DP  - 2011 Oct-Dec
TI  - Settled precepts: normative ethics, applied ethics and physician complicity with 
      torture.
PG  - 191-6
FAU - Miles, Steven H
AU  - Miles SH
AD  - Center for Bioethics, University of Minnesota, Minneapolis, MN, USA.
      miles001@umn.edu
LA  - eng
PT  - Journal Article
PL  - England
TA  - Med Confl Surviv
JT  - Medicine, conflict, and survival
JID - 9612305
SB  - IM
MH  - *Complicity
MH  - Ethical Theory
MH  - *Ethics, Medical
MH  - Humans
MH  - *Physicians
MH  - *Torture
EDAT- 2012/03/16 06:00
MHDA- 2012/05/04 06:00
CRDT- 2012/03/16 06:00
PHST- 2012/03/16 06:00 [entrez]
PHST- 2012/03/16 06:00 [pubmed]
PHST- 2012/05/04 06:00 [medline]
AID - 10.1080/13623699.2011.645147 [doi]
PST - ppublish
SO  - Med Confl Surviv. 2011 Oct-Dec;27(4):191-6. doi: 10.1080/13623699.2011.645147.


PMID- 22411403
OWN - NLM
STAT- MEDLINE
DCOM- 20120703
LR  - 20191210
IS  - 1699-5198 (Electronic)
IS  - 0212-1611 (Linking)
VI  - 26
IP  - 6
DP  - 2011 Nov-Dec
TI  - [Ethics and scientific publication].
PG  - 1492
LID - 10.1590/S0212-16112011000600044 [doi]
LID - S0212-16112011000600044 [pii]
FAU - Arribalzaga, E B
AU  - Arribalzaga EB
LA  - spa
PT  - Letter
TT  - Etica en las publicaciones cientificas.
PL  - Spain
TA  - Nutr Hosp
JT  - Nutricion hospitalaria
JID - 9100365
SB  - IM
MH  - Biomedical Research
MH  - Duplicate Publications as Topic
MH  - Plagiarism
MH  - Research
MH  - *Scientific Misconduct/ethics
EDAT- 2012/03/14 06:00
MHDA- 2012/07/04 06:00
CRDT- 2012/03/14 06:00
PHST- 2012/03/14 06:00 [entrez]
PHST- 2012/03/14 06:00 [pubmed]
PHST- 2012/07/04 06:00 [medline]
AID - S0212-16112011000600044 [pii]
AID - 10.1590/S0212-16112011000600044 [doi]
PST - ppublish
SO  - Nutr Hosp. 2011 Nov-Dec;26(6):1492. doi: 10.1590/S0212-16112011000600044.


PMID- 22411365
OWN - NLM
STAT- MEDLINE
DCOM- 20120703
LR  - 20130702
IS  - 1699-5198 (Electronic)
IS  - 0212-1611 (Linking)
VI  - 26
IP  - 6
DP  - 2011 Nov-Dec
TI  - [Ethical questions related to nutrition and hidration: basic aspects].
PG  - 1231-5
LID - 10.1590/S0212-16112011000600006 [doi]
LID - S0212-16112011000600006 [pii]
AB  - Conditions that pose ethical problems related to nutrition and hydration are very
      common nowdays, particularly within Hospitals among terminally ill patients and
      other patients who require nutrition and hydration. In this article we intend to 
      analyze some circumstances, according to widely accepted ethical values, in order
      to outline a clear action model to help clinicians in making such difficult
      decisions. The problematic situations analyzed include: should hydration and
      nutrition be considered basic care or therapeutic measures?, and the ethical
      aspects of enteral versus parenteral nutrition.
FAU - Collazo Chao, E
AU  - Collazo Chao E
AD  - Unidad de Atencion al Pie Diabetico e Insuficiencia Venosa Cronica, Hospital
      Universitario Reina Sofia de Cordoba, Cordoba, Espana. ecollazo@comcordoba.com
FAU - Girela, E
AU  - Girela E
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Problemas eticos en relacion a la nutricion y a la hidratacion: aspectos basicos.
PL  - Spain
TA  - Nutr Hosp
JT  - Nutricion hospitalaria
JID - 9100365
SB  - IM
MH  - *Ethics, Medical
MH  - Fluid Therapy/*ethics
MH  - Humans
MH  - Intubation, Gastrointestinal
MH  - Nutritional Support/*ethics
MH  - Parenteral Nutrition/ethics
EDAT- 2012/03/14 06:00
MHDA- 2012/07/04 06:00
CRDT- 2012/03/14 06:00
PHST- 2011/04/02 00:00 [received]
PHST- 2011/06/23 00:00 [accepted]
PHST- 2012/03/14 06:00 [entrez]
PHST- 2012/03/14 06:00 [pubmed]
PHST- 2012/07/04 06:00 [medline]
AID - S0212-16112011000600006 [pii]
AID - 10.1590/S0212-16112011000600006 [doi]
PST - ppublish
SO  - Nutr Hosp. 2011 Nov-Dec;26(6):1231-5. doi: 10.1590/S0212-16112011000600006.


PMID- 22410769
OWN - NLM
STAT- MEDLINE
DCOM- 20120727
LR  - 20181201
IS  - 1552-8448 (Electronic)
IS  - 1077-8012 (Linking)
VI  - 17
IP  - 12
DP  - 2011 Dec
TI  - Research ethics in victimization studies: widening the lens.
PG  - 1536-48; discussion 1549-58
LID - 10.1177/1077801211436365 [doi]
FAU - Cromer, Lisa DeMarni
AU  - Cromer LD
AD  - Department of Psychology, Tulsa Institute of Trauma, Abuse, and Neglect,
      University of Tulsa, 800 South Tucker Dr., Tulsa, OK 74104-3189, USA.
      elana-newman@utulsa.edu
FAU - Newman, Elana
AU  - Newman E
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Violence Against Women
JT  - Violence against women
JID - 9506308
SB  - IM
CON - Violence Against Women. 2011 Dec;17(12):1489-508. PMID: 22410765
MH  - *Crime Victims
MH  - *Ethics, Research
MH  - Female
MH  - Humans
MH  - Male
MH  - Social Sciences/*ethics
MH  - *Spouse Abuse
EDAT- 2012/03/14 06:00
MHDA- 2012/07/28 06:00
CRDT- 2012/03/14 06:00
PHST- 2012/03/14 06:00 [entrez]
PHST- 2012/03/14 06:00 [pubmed]
PHST- 2012/07/28 06:00 [medline]
AID - 17/12/1536 [pii]
AID - 10.1177/1077801211436365 [doi]
PST - ppublish
SO  - Violence Against Women. 2011 Dec;17(12):1536-48; discussion 1549-58. doi:
      10.1177/1077801211436365.


PMID- 22410768
OWN - NLM
STAT- MEDLINE
DCOM- 20120727
LR  - 20181201
IS  - 1552-8448 (Electronic)
IS  - 1077-8012 (Linking)
VI  - 17
IP  - 12
DP  - 2011 Dec
TI  - Research ethics in victimization studies: widening the lens: a response and
      alternative view.
PG  - 1529-35; discussion 1549-58
LID - 10.1177/1077801211436304 [doi]
FAU - Cerulli, Catherine
AU  - Cerulli C
AD  - University of Rochester Medical Center, Department of Psychiatry, 300 Crittenden 
      Blvd., Rochester, NY 14642, USA. Catherine_Cerulli@urmc.rochester.edu
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Violence Against Women
JT  - Violence against women
JID - 9506308
SB  - IM
CON - Violence Against Women. 2011 Dec;17(12):1489-508. PMID: 22410765
MH  - *Crime Victims
MH  - *Ethics, Research
MH  - Female
MH  - Humans
MH  - Male
MH  - Social Sciences/*ethics
MH  - *Spouse Abuse
EDAT- 2012/03/14 06:00
MHDA- 2012/07/28 06:00
CRDT- 2012/03/14 06:00
PHST- 2012/03/14 06:00 [entrez]
PHST- 2012/03/14 06:00 [pubmed]
PHST- 2012/07/28 06:00 [medline]
AID - 17/12/1529 [pii]
AID - 10.1177/1077801211436304 [doi]
PST - ppublish
SO  - Violence Against Women. 2011 Dec;17(12):1529-35; discussion 1549-58. doi:
      10.1177/1077801211436304.


PMID- 22410766
OWN - NLM
STAT- MEDLINE
DCOM- 20120727
LR  - 20181201
IS  - 1552-8448 (Electronic)
IS  - 1077-8012 (Linking)
VI  - 17
IP  - 12
DP  - 2011 Dec
TI  - Gendered violence and the ethics of social science research.
PG  - 1509-20; discussion 1549-58
LID - 10.1177/1077801211436169 [doi]
FAU - Mulla, Sameena
AU  - Mulla S
AD  - Department of Social and Cultural Sciences, Marquette University, Lalumiere
      Language Hall, 412, Milwaukee, WI 53201-1881, USA. sameena.mulla@marquette.edu
FAU - Hlavka, Heather
AU  - Hlavka H
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Violence Against Women
JT  - Violence against women
JID - 9506308
SB  - IM
CON - Violence Against Women. 2011 Dec;17(12):1489-508. PMID: 22410765
MH  - *Crime Victims
MH  - *Ethics, Research
MH  - Female
MH  - Humans
MH  - Male
MH  - Social Sciences/*ethics
MH  - *Spouse Abuse
EDAT- 2012/03/14 06:00
MHDA- 2012/07/28 06:00
CRDT- 2012/03/14 06:00
PHST- 2012/03/14 06:00 [entrez]
PHST- 2012/03/14 06:00 [pubmed]
PHST- 2012/07/28 06:00 [medline]
AID - 17/12/1509 [pii]
AID - 10.1177/1077801211436169 [doi]
PST - ppublish
SO  - Violence Against Women. 2011 Dec;17(12):1509-20; discussion 1549-58. doi:
      10.1177/1077801211436169.


PMID- 22410765
OWN - NLM
STAT- MEDLINE
DCOM- 20120727
LR  - 20120313
IS  - 1552-8448 (Electronic)
IS  - 1077-8012 (Linking)
VI  - 17
IP  - 12
DP  - 2011 Dec
TI  - Research ethics in victimization studies: widening the lens.
PG  - 1489-508
LID - 10.1177/1077801211436167 [doi]
AB  - Research ethics, especially the protection of research study participants, has
      been an enduring concern of investigators and scholars of victims of violence.
      Previous work has analyzed the overt and hidden risks of harm to study
      participants through poorly designed and implemented protocols, cross-cultural
      insensitivity, unjust exclusion of certain victim types, and neglect to ensure
      safety of research staff. This article extends this work by calling for greater
      attention to exploiting participants and victims as a class of persons. The need 
      for this wider view derives from concern about the academic research environment 
      with its emphasis on research, publication, and extramural funding. The authors
      argue that compliance with federal regulations and IRB directives is necessary
      but insufficient to conduct truly ethical research. Recognition of the unique
      pressures that researchers face in the context of the economically competitive
      university is required to delineate and manage exploitation risks. Such pressures
      have sometimes led to the rush from print to practices and policies with
      unintended harmful results for victims of violence as a class of persons. The
      authors suggest a number of strategies for researchers to define and manage the
      dangers of engaging in this type of unethical conduct.
FAU - Clark, James J
AU  - Clark JJ
AD  - College of Social Work, University of Kentucky, 659 Patterson Office Tower,
      Lexington, KY 40506-0027, USA. james.clark1@uky.edu
FAU - Walker, Robert
AU  - Walker R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Violence Against Women
JT  - Violence against women
JID - 9506308
SB  - IM
CIN - Violence Against Women. 2011 Dec;17(12):1509-20; discussion 1549-58. PMID:
      22410766
CIN - Violence Against Women. 2011 Dec;17(12):1521-8; discussion 1549-58. PMID:
      22410767
CIN - Violence Against Women. 2011 Dec;17(12):1529-35; discussion 1549-58. PMID:
      22410768
CIN - Violence Against Women. 2011 Dec;17(12):1536-48; discussion 1549-58. PMID:
      22410769
MH  - *Crime Victims
MH  - Ethics Committees, Research
MH  - *Ethics, Research
MH  - Female
MH  - Humans
MH  - Informed Consent
MH  - Male
MH  - Social Sciences/*ethics
MH  - *Spouse Abuse
EDAT- 2012/03/14 06:00
MHDA- 2012/07/28 06:00
CRDT- 2012/03/14 06:00
PHST- 2012/03/14 06:00 [entrez]
PHST- 2012/03/14 06:00 [pubmed]
PHST- 2012/07/28 06:00 [medline]
AID - 17/12/1489 [pii]
AID - 10.1177/1077801211436167 [doi]
PST - ppublish
SO  - Violence Against Women. 2011 Dec;17(12):1489-508. doi: 10.1177/1077801211436167.


PMID- 22397184
OWN - NLM
STAT- MEDLINE
DCOM- 20120405
LR  - 20220408
IS  - 0723-1393 (Print)
IS  - 0723-1393 (Linking)
VI  - 30
IP  - 4
DP  - 2011 Dec
TI  - Consent to medical research of vulnerable subjects from the French point of view:
      the example of consent in research in the case of Alzheimer disease.
PG  - 613-27
AB  - The consent to research is the expression of autonomy. Some groups are vulnerable
      and cannot give free consent because their conditions limit their decision making
      or because they are unable to consent themselves (minor, incompetent adults).
      International standards and recommendations for medical research protect
      vulnerable subjects (article 17 of the Helsinki declaration, guidelines 9 and 13 
      of the CIOMS, article 17 of the Oviedo Convention). French Law protects mostly
      three categories of vulnerable people: minors, adults with a legal
      representative, and the people living in sanitary and social establishments.
      Specific protection is given as well to pregnant women, detainees and persons
      with psychiatric disorders in involuntary commitment. From the example of
      research with Alzheimer patients the authors show the original provisions of
      French legislation to involve in medical research incompetent patients with or
      without legal protection. Clinical research on Alzheimer's disease poses
      challenges as never before to research ethics. In fact, the development of the
      disease progressively reduces the patient's ability to make choices: the latter
      is no longer capable, but is not totally incapacitated. Several solutions are
      offered for a "proxy" consent or authorisation.
FAU - Duguet, Anne-Marie
AU  - Duguet AM
AD  - Inserm, Unite 1027 Toulouse, France.
FAU - Boyer-Beviere, Benedicte
AU  - Boyer-Beviere B
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Law
JT  - Medicine and law
JID - 8218185
SB  - IM
MH  - Adult
MH  - *Alzheimer Disease
MH  - France
MH  - Helsinki Declaration
MH  - Human Experimentation/ethics/*legislation & jurisprudence
MH  - Human Rights/legislation & jurisprudence
MH  - Humans
MH  - Informed Consent/*legislation & jurisprudence
MH  - Personal Autonomy
MH  - Vulnerable Populations
EDAT- 2012/03/09 06:00
MHDA- 2012/04/06 06:00
CRDT- 2012/03/09 06:00
PHST- 2012/03/09 06:00 [entrez]
PHST- 2012/03/09 06:00 [pubmed]
PHST- 2012/04/06 06:00 [medline]
PST - ppublish
SO  - Med Law. 2011 Dec;30(4):613-27.


PMID- 22397176
OWN - NLM
STAT- MEDLINE
DCOM- 20120405
LR  - 20170203
IS  - 0723-1393 (Print)
IS  - 0723-1393 (Linking)
VI  - 30
IP  - 4
DP  - 2011 Dec
TI  - Is the codification of vulnerability in international documents a sufficient
      mechanism of protection in the clinical research ethics context?
PG  - 497-515
AB  - In this paper, I argue that the codification of vulnerability in international
      regulatory guidelines, such as the Declaration of Helsinki and the document
      issued by the Council for International Organizations of Medical Sciences on
      International Ethical Guidelines for Biomedical Research Involving Human
      Subjects, do not sufficiently protect research subjects. This is true in
      particular when research is designed in developed countries but conducted in poor
      (African) countries. Furthermore, I argue that the reason for the insufficiency
      of guidelines in protecting research subjects in poor settings is due to
      vagueness in those international documents. Hence, the need for a supplementary
      instrument of protection was suggested to be employed in addition to
      international regulatory documents when clinical research is designed to be
      conducted in developing countries by investigators from affluent countries.
FAU - Omonzejele, Peter F
AU  - Omonzejele PF
AD  - Department Of Philosophy, University Of Benin, Benin-City, Nigeria.
      pomonzejele@yahoo.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Law
JT  - Medicine and law
JID - 8218185
SB  - IM
MH  - Clinical Trials as Topic/*ethics
MH  - *Developing Countries
MH  - Helsinki Declaration
MH  - Human Experimentation/ethics/*legislation & jurisprudence
MH  - Humans
MH  - Internationality
MH  - Research Subjects/*legislation & jurisprudence
EDAT- 2012/03/09 06:00
MHDA- 2012/04/06 06:00
CRDT- 2012/03/09 06:00
PHST- 2012/03/09 06:00 [entrez]
PHST- 2012/03/09 06:00 [pubmed]
PHST- 2012/04/06 06:00 [medline]
PST - ppublish
SO  - Med Law. 2011 Dec;30(4):497-515.


PMID- 22397173
OWN - NLM
STAT- MEDLINE
DCOM- 20120405
LR  - 20170203
IS  - 0723-1393 (Print)
IS  - 0723-1393 (Linking)
VI  - 30
IP  - 4
DP  - 2011 Dec
TI  - Reflections on international medical law.
PG  - 449-60
AB  - Does international medical law exist, in the first place, as an independent area 
      of study? If so, is it urgently required in an era of comparative studies?
      Namely, to what extent, if at all, international studies differ from comparative 
      ones? Besides, what are the particular characteristics of such international
      discipline? Namely, what are the particular features of this field that elaborate
      on our legal and scientific understanding in sketching possible definition for
      this notion of "international medical law?" In addition, how does international
      medical law correlate with health, ethics and health policies in our globalized
      world? And finally, what are the challenges that might face the international
      community, once the concept of "international medical law" is acknowledged? This 
      papers aims at establishing the conceptual grounds for these questions, thus
      calling for the acknowledgment of a new field of study described as
      "international medical law".
FAU - Wattad, Mohammed S
AU  - Wattad MS
AD  - Zefat Academic College.
FAU - Hrevtsova, Radmyla Yu
AU  - Hrevtsova RY
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Law
JT  - Medicine and law
JID - 8218185
SB  - IM
MH  - Delivery of Health Care/*legislation & jurisprudence
MH  - Human Rights/legislation & jurisprudence
MH  - Humans
MH  - *Internationality
EDAT- 2012/03/09 06:00
MHDA- 2012/04/06 06:00
CRDT- 2012/03/09 06:00
PHST- 2012/03/09 06:00 [entrez]
PHST- 2012/03/09 06:00 [pubmed]
PHST- 2012/04/06 06:00 [medline]
PST - ppublish
SO  - Med Law. 2011 Dec;30(4):449-60.


PMID- 22397142
OWN - NLM
STAT- MEDLINE
DCOM- 20120327
LR  - 20120308
IS  - 1565-4753 (Print)
IS  - 1565-4753 (Linking)
VI  - 9
IP  - 2
DP  - 2011 Dec
TI  - Growth hormone treatment for short stature: a review of psychosocial assumptions 
      and empirical evidence.
PG  - 579-88; quiz 589
AB  - The advent of the unlimited availability of recombinant human growth hormone
      (rhGH) ushered in a new era of clinical management options and decisions for
      children with short stature, in particular, for those without GH deficiency.
      Ethical questions about treating non-GH-deficient short-statured children with
      rhGH quickly arose. After over two decades and after several additional
      indications for rhGH use in children were approved, many issues remain relevant
      today, e.g., under what circumstances should rhGH be used; is rhGH a treatment
      for psychosocial problems; and do benefits outweigh risks? Ideally, findings from
      large placebo-controlled randomized clinical trials would inform clinical
      management decisions; however, their conduct has proved infeasible thus far.
      Still, mounting research evidence has addressed many aspects of the controversies
      in this area of elective care. Clinicians are encouraged to systematically
      explore alternative, evidence-based options to rhGH treatment with parents and
      patients as a remedy for any perceived liabilities of SS, either in the present
      or future.
FAU - Gardner, Melissa
AU  - Gardner M
AD  - Department of Pediatrics and Communicable Diseases, Child Behavioral Health,
      University of Michigan Medical School and C.S. Mott Children's Hospital, Ann
      Arbor, MI, USA.
FAU - Sandberg, David E
AU  - Sandberg DE
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Israel
TA  - Pediatr Endocrinol Rev
JT  - Pediatric endocrinology reviews : PER
JID - 101202124
RN  - 12629-01-5 (Human Growth Hormone)
SB  - IM
MH  - Adaptation, Psychological/drug effects/physiology
MH  - Body Height/physiology
MH  - Child
MH  - Disabled Children/psychology/statistics & numerical data
MH  - Dwarfism/drug therapy/psychology
MH  - Empirical Research
MH  - Growth Disorders/diagnosis/*drug therapy/epidemiology/*psychology
MH  - Human Growth Hormone/deficiency/*therapeutic use
MH  - Humans
MH  - Psychology
EDAT- 2012/03/09 06:00
MHDA- 2012/03/28 06:00
CRDT- 2012/03/09 06:00
PHST- 2012/03/09 06:00 [entrez]
PHST- 2012/03/09 06:00 [pubmed]
PHST- 2012/03/28 06:00 [medline]
PST - ppublish
SO  - Pediatr Endocrinol Rev. 2011 Dec;9(2):579-88; quiz 589.


PMID- 22397091
OWN - NLM
STAT- MEDLINE
DCOM- 20120410
LR  - 20211021
IS  - 1321-2753 (Print)
IS  - 1321-2753 (Linking)
VI  - 29
IP  - 4
DP  - 2011 Sep
TI  - Research governance and change in research ethics practices at a major Australian
      university.
PG  - 16.1-7
AB  - Recent revisions of the National Statement on Ethical Conduct in Human Research
      and the Australian Code for the Responsible Conduct of Research put a great
      emphasis on research governance. Institutional responsibility for the governance 
      of the research is not limited only to the ethical review by the Human Research
      Ethics Committee (HREC), but also to the accountability for quality, safety,
      privacy, risk management and financial management of the research. Despite the
      development of proposed research governance frameworks, many Australian
      institutions do not have such structures in place and rely excessively on HRECs
      to perform administrative functions that are not their responsibility. In this
      paper we report on implementation of a research governance framework at
      University of New South Wales which led to reduced HREC workload and allowed more
      attention to its core functions. We present the approach undertaken by the
      university to separate the ethical review process by HREC from the research
      governance. We recommend that with proper research governance frameworks in
      place, the role of HRECs and the institutional responsibility of governance of
      the research can be defined clearly.
FAU - Krastev, Yordanka
AU  - Krastev Y
AD  - University of New South Wales.
FAU - Grimm, Michael
AU  - Grimm M
FAU - Metcalfe, Andrew
AU  - Metcalfe A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Monash Bioeth Rev
JT  - Monash bioethics review
JID - 100973394
SB  - IM
MH  - Ethics Committees, Research/*organization & administration
MH  - *Ethics, Research
MH  - Humans
MH  - New South Wales
MH  - Organizational Innovation
MH  - Peer Review, Research
MH  - *Professional Role
EDAT- 2012/03/09 06:00
MHDA- 2012/04/11 06:00
CRDT- 2012/03/09 06:00
PHST- 2012/03/09 06:00 [entrez]
PHST- 2012/03/09 06:00 [pubmed]
PHST- 2012/04/11 06:00 [medline]
AID - 10.1007/BF03351330 [doi]
PST - ppublish
SO  - Monash Bioeth Rev. 2011 Sep;29(4):16.1-7. doi: 10.1007/BF03351330.


PMID- 22397090
OWN - NLM
STAT- MEDLINE
DCOM- 20120410
LR  - 20211021
IS  - 1321-2753 (Print)
IS  - 1321-2753 (Linking)
VI  - 29
IP  - 4
DP  - 2011 Sep
TI  - Contextualising merit and integrity within human research.
PG  - 15.1-10
AB  - The first consideration of any Australian Human Research Ethics Committee should 
      be to satisfy itself that the project before them is worth undertaking. If the
      project does not add to the body of knowledge, if it does not improve social
      welfare or individual wellbeing then the use of human participants, their tissue 
      or their data must be questioned. Sometimes, however, committees are criticised
      for appearing to adopt the role of scientific review committees. The intent of
      this paper is to provide researchers with an understanding of the ethical
      importance of demonstrating the merit of their research project and to help them 
      develop protocols that show ethics committees that adequate attention has been
      paid to this central tenet in dealing ethically with human research participants.
      Any person proposing human research must be prepared to show that it is
      worthwhile. This paper will clarify the relationship between research merit and
      integrity, research ethics and the responsibilities of human research ethics
      committees.
FAU - Pieper, Ian
AU  - Pieper I
AD  - Queensland Health. pieper@live.co.uk
FAU - Thomson, Colin J H
AU  - Thomson CJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Monash Bioeth Rev
JT  - Monash bioethics review
JID - 100973394
SB  - IM
MH  - Australia
MH  - Conflict of Interest
MH  - *Ethics Committees, Research
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Information Dissemination
MH  - *Professional Role
MH  - *Research Design
EDAT- 2012/03/09 06:00
MHDA- 2012/04/11 06:00
CRDT- 2012/03/09 06:00
PHST- 2012/03/09 06:00 [entrez]
PHST- 2012/03/09 06:00 [pubmed]
PHST- 2012/04/11 06:00 [medline]
AID - 10.1007/BF03351329 [doi]
PST - ppublish
SO  - Monash Bioeth Rev. 2011 Sep;29(4):15.1-10. doi: 10.1007/BF03351329.


PMID- 22397089
OWN - NLM
STAT- MEDLINE
DCOM- 20120410
LR  - 20120308
IS  - 1321-2753 (Print)
IS  - 1321-2753 (Linking)
VI  - 29
IP  - 4
DP  - 2011 Sep
TI  - Ethics creep or governance creep? Challenges for Australian Human Research Ethics
      Committees (HRECS).
PG  - 14.1-16
AB  - Australian Human Research Ethics Committees (HRECs) have to contend with
      ever-increasing workloads and responsibilities which go well beyond questions of 
      mere ethics. In this article, I shall examine how the roles of HRECs have
      changed, and show how this is reflected in the iterations of the National
      Statement on Ethical Conduct in Human Research 2007 (NS). In particular I suggest
      that the focus of the National Statement has shifted to concentrate on matters of
      research governance at the expense of research ethics, compounded by its linkage 
      to the Australian Code for the Responsible Conduct of Research (2007) in its most
      recent iteration. I shall explore some of the challenges this poses for HRECs and
      institutions and the risks it poses to ensuring that Australian researchers
      receive clear ethical guidance and review.
FAU - Gorman, Susanna M
AU  - Gorman SM
AD  - Susanna M. Gorman, Macquarie University.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Monash Bioeth Rev
JT  - Monash bioethics review
JID - 100973394
SB  - IM
MH  - Australia
MH  - Codes of Ethics
MH  - Ethics Committees, Research/organization & administration/*trends
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Peer Review, Research
MH  - *Professional Role
MH  - Workload
EDAT- 2012/03/09 06:00
MHDA- 2012/04/11 06:00
CRDT- 2012/03/09 06:00
PHST- 2012/03/09 06:00 [entrez]
PHST- 2012/03/09 06:00 [pubmed]
PHST- 2012/04/11 06:00 [medline]
PST - ppublish
SO  - Monash Bioeth Rev. 2011 Sep;29(4):14.1-16.


PMID- 22397088
OWN - NLM
STAT- MEDLINE
DCOM- 20120410
LR  - 20211021
IS  - 1321-2753 (Print)
IS  - 1321-2753 (Linking)
VI  - 29
IP  - 4
DP  - 2011 Sep
TI  - Where Christ did not go: men, women and Frusculicchi. Gender identity disorder
      (GID): epistemological and ethical issues relating to the psychiatric diagnosis.
PG  - 12.1-22
AB  - Gender Identity Disorder (GID) is classified as a mental illness and included in 
      the DSM-IV and ICD-1O. It will also be included in the DSM-V. The psychiatric
      diagnosis, in spite of some apparent advantages, has significant psychological
      and social adverse implications. This paper discusses some of the main
      epistemological reasons to consider gender variance as a mental disorder. It will
      also evaluate whether reasons of other kinds (pragmatic, rather than
      epistemological) may justify the inclusion of gender variance amongst mental
      illnesses.
FAU - Giordano, Simona
AU  - Giordano S
AD  - Simona Giordano, University of Manchester.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Monash Bioeth Rev
JT  - Monash bioethics review
JID - 100973394
SB  - IM
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Female
MH  - *Human Rights
MH  - Humans
MH  - Male
MH  - Prejudice
MH  - Psychiatry/*ethics
MH  - Public Policy
MH  - Social Isolation
MH  - Transsexualism/*diagnosis/psychology
EDAT- 2012/03/09 06:00
MHDA- 2012/04/11 06:00
CRDT- 2012/03/09 06:00
PHST- 2012/03/09 06:00 [entrez]
PHST- 2012/03/09 06:00 [pubmed]
PHST- 2012/04/11 06:00 [medline]
PST - ppublish
SO  - Monash Bioeth Rev. 2011 Sep;29(4):12.1-22.


PMID- 22396872
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 2152-5250 (Electronic)
IS  - 2152-5250 (Linking)
VI  - 2
IP  - 2
DP  - 2011 Apr
TI  - Aging and transplantation - a topic for biomedicine or bioethics?
PG  - 181-5
AB  - The aged patient stands at the nexus of significant biomedical and bioethical
      issues in transplantation. This in itself can be seen as a microcosm of an
      imminent global tempest, stemming from expanding numbers and longer lives of the 
      aged population. As a candidate for receiving organ and tissue transplants, the
      geriatric patient is challenging because they present unique physiology for
      medical management. As organ and tissue donors, the aged are perceived of as
      providing "marginal" organs, which drives the fear that the graft will fail
      before the recipient. Such difficulties lead inexorably to several unique
      bioethical considerations for transplantation with this population. The thorny
      conundrums for society hinge on fairness versus discrimination based on age,
      played out under the enormous and probably intractable problem of severe donor
      organ shortages. Fortunately, recent findings offer some rather unexpected new
      and favorable prospects. Notably, aged donors can provide organs with good,
      lifesaving function, even though there are nonetheless age-related compromises
      present. On the other side of the coin, there is less doubt that recipients can
      have their lives extended with high quality through transplantation. Here they
      benefit from some (counterintuitively) positive attributes for aging, such as
      reduced immune function, making immunosuppression less rigorous. Finally, the
      pressure of organ and tissue shortages plus the lifting of bans on embryonic stem
      cell research have portents for an explosive alternative to transplantation of
      adult organs. Stem cells also lend credibility to prospects for realizing
      regenerative medicine, assuming ethical and religious concerns can be satisfied.
FAU - Hubbard, William J
AU  - Hubbard WJ
AD  - University of Alabama at Birmingham, Department of Surgery, Center for Surgical
      Research and.
FAU - Dashti, Nassrin
AU  - Dashti N
LA  - eng
PT  - Journal Article
DEP - 20110222
PL  - United States
TA  - Aging Dis
JT  - Aging and disease
JID - 101540533
PMC - PMC3295047
OTO - NOTNLM
OT  - Adult Stem Cell
OT  - Aging
OT  - Bioethics
OT  - Donor
OT  - Embryonic Stem Cell
OT  - Immunosenescence
OT  - Immunosuppression
OT  - Recipient
OT  - Transplant
EDAT- 2012/03/08 06:00
MHDA- 2012/03/08 06:01
CRDT- 2012/03/08 06:00
PHST- 2011/02/10 00:00 [received]
PHST- 2011/02/18 00:00 [revised]
PHST- 2011/02/21 00:00 [accepted]
PHST- 2012/03/08 06:00 [entrez]
PHST- 2012/03/08 06:00 [pubmed]
PHST- 2012/03/08 06:01 [medline]
PST - ppublish
SO  - Aging Dis. 2011 Apr;2(2):181-5. Epub 2011 Feb 22.


PMID- 22379656
STAT- Publisher
DA  - 20120302
ISBN- 9780309219518
ISBN- 0309219515
PB  - National Academies Press (US)
CTI - The National Academies Collection: Reports funded by National Institutes of
      Health
DP  - 2011
BTI - Guidance for the Description of Animal Research in Scientific Publications
AB  - The committee (Committee on Guidelines for Scientific Publications Involving
      Animal Studies) believes that journal editors have a role to play in promoting
      the proper use of animals in research through the publication of adequate
      descriptions. The committee urges journal editors to actively promote effective
      and ethical research by encouraging the provision of sufficient information to
      enable assessment and interpretation of research findings and advancement of
      knowledge based on reproducible results. This report provides journal editors,
      authors, and reviewers with guidance (and supporting references) for effective
      reporting of animal research in published articles based on adequate descriptions
      of: the research animal (section 3), with detailed information about the animals'
      age, sex, weight, and life stage (3.1), source (3.2), genetic nomenclature (3.3),
      microbial/pathogen status (3.4), and preparation and assignment (including
      control groups)(3.5); the research animal environment (sections 4 and, for
      aquatic animals, 6), with detailed information about the micro- and
      macroenvironment (4.4 and 6.1), diet (4.1 and 6.2),water (4.2), and housing (4.3 
      and 6.3); basic animal methodology, including aspects of animal care and use that
      can affect research outcomes (section 5), with detailed information about
      experimental effects (5.1), administration of substances (5.2), use of infectious
      agents (5.3), sample acquisition (5.4), and euthanasia (5.5). The ability to
      interpret, evaluate, and reproduce biomedical and other types of laboratory
      animal research and testing is a reasonable minimum standard for the assessment
      of effective reporting in research articles. Journal editors can substantially
      contribute to the achievement of this standard through the articulation of clear 
      policies and criteria for their authors and reviewers. This report complements
      existing checklists and resources by providing guidance and scientific evidence
      for the specific types of information that should be included in research
      publications to promote the advancement of science involving animal studies. It
      also describes approaches to facilitate the provision of such information.
CI  - Copyright (c) 2011, National Academy of Sciences.
CN  - National Research Council (US) Institute for Laboratory Animal Research
LA  - eng
GR  - N01 OD042139/NIH HHS/United States
PT  - Review
PT  - Book
PL  - Washington (DC)
EDAT- 2012/03/02 06:00
MHDA- 2012/03/02 06:00
CDAT- 2012/03/02 06:00
AID - NBK84205 [bookaccession]
AID - 10.17226/13241 [doi]


PMID- 22379530
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130704
LR  - 20211021
IS  - 1949-8357 (Electronic)
IS  - 1949-8357 (Linking)
VI  - 3
IP  - 1
DP  - 2011 Mar
TI  - Morbidity and mortality conference in obstetrics and gynecology: a tool for
      addressing the 6 core competencies.
PG  - 100-3
LID - 10.4300/JGME-D-10-00093.1 [doi]
AB  - BACKGROUND: Residency program directors are challenged to effectively teach and
      assess the Accreditation Council for Graduate Medical Education's (ACGME) 6
      competencies. The purpose of this study was to characterize the morbidity and
      mortality (M&M) conference as a cost-effective and efficient approach for
      addressing the ACGME competencies through evaluation of resident participation
      and case diversity. METHODS: In our modified M&M conference, senior residents
      submit a weekly list of cases to the conference proctors. The resident presents
      the case, including a critique of management, using the medical literature. The
      resident submits a case summary evaluating patient care practices, integrating
      scientific evidence, and evaluating systemic barriers to care. Completed case
      summaries are distributed and archived for reference. RESULTS: During a 3-year
      period, 30 residents presented 196 cases. Of these, 37 (19%) directly related to 
      systems-based practice, 20 (10%) involved problems with inadequate communication,
      and 11 (6%) included issues of professionalism or ethics. All cases involved
      practice-based learning and medical knowledge. CONCLUSIONS: The M&M conference
      addresses the core competencies through resident participation as well as
      directed analysis of diverse cases.
FAU - Bevis, Kerri S
AU  - Bevis KS
FAU - Straughn, J Michael Jr
AU  - Straughn JM Jr
FAU - Kendrick, James E
AU  - Kendrick JE
FAU - Walsh-Covarrubias, Julie
AU  - Walsh-Covarrubias J
FAU - Kilgore, Larry C
AU  - Kilgore LC
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Grad Med Educ
JT  - Journal of graduate medical education
JID - 101521733
PMC - PMC3186274
EDAT- 2012/03/02 06:00
MHDA- 2012/03/02 06:01
CRDT- 2012/03/02 06:00
PHST- 2010/05/27 00:00 [received]
PHST- 2010/08/22 00:00 [revised]
PHST- 2010/10/07 00:00 [accepted]
PHST- 2012/03/02 06:00 [entrez]
PHST- 2012/03/02 06:00 [pubmed]
PHST- 2012/03/02 06:01 [medline]
AID - 10.4300/JGME-D-10-00093.1 [doi]
AID - JGME-D-10-00093 [pii]
PST - ppublish
SO  - J Grad Med Educ. 2011 Mar;3(1):100-3. doi: 10.4300/JGME-D-10-00093.1.


PMID- 22379312
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 0974-942X (Electronic)
IS  - 0972-8270 (Linking)
VI  - 10
IP  - 1
DP  - 2011 Mar
TI  - Will the real author please stand up!
PG  - 2-3
LID - 10.1007/s12663-011-0224-y [doi]
AB  - This is a Guest editorial on the ethics of authorship in scientific publications.
      The editorial analyzes the qualification and roles of an author. It also
      discusses controversial issues and the relevance of the order of authorship in
      bio-medical journal publications.
FAU - Paul, George
AU  - Paul G
AD  - Paulose Maxillofacial Centre, Salem, India.
LA  - eng
PT  - Journal Article
DEP - 20110422
PL  - India
TA  - J Maxillofac Oral Surg
JT  - Journal of maxillofacial and oral surgery
JID - 101538309
PMC - PMC3177506
EDAT- 2012/03/02 06:00
MHDA- 2012/03/02 06:01
CRDT- 2012/03/02 06:00
PHST- 2011/03/31 00:00 [received]
PHST- 2011/04/03 00:00 [accepted]
PHST- 2012/03/02 06:00 [entrez]
PHST- 2012/03/02 06:00 [pubmed]
PHST- 2012/03/02 06:01 [medline]
AID - 10.1007/s12663-011-0224-y [doi]
AID - 224 [pii]
PST - ppublish
SO  - J Maxillofac Oral Surg. 2011 Mar;10(1):2-3. doi: 10.1007/s12663-011-0224-y. Epub 
      2011 Apr 22.


PMID- 22379193
OWN - NLM
STAT- MEDLINE
DCOM- 20120406
LR  - 20211021
IS  - 0008-5286 (Print)
IS  - 0008-5286 (Linking)
VI  - 52
IP  - 9
DP  - 2011 Sep
TI  - Veterinary medical ethics. An ethicist's commentary on performing animal research
      in countries with lax regulatory structures.
PG  - 927-8
FAU - Rollin, Bernard E
AU  - Rollin BE
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Vet J
JT  - The Canadian veterinary journal = La revue veterinaire canadienne
JID - 0004653
SB  - IM
MH  - Animal Experimentation/*legislation & jurisprudence
MH  - *Animal Welfare/legislation & jurisprudence
MH  - Animals
MH  - *Ethics, Research
MH  - Humans
MH  - Species Specificity
PMC - PMC3157066
EDAT- 2012/03/02 06:00
MHDA- 2012/04/07 06:00
CRDT- 2012/03/02 06:00
PHST- 2012/03/02 06:00 [entrez]
PHST- 2012/03/02 06:00 [pubmed]
PHST- 2012/04/07 06:00 [medline]
PST - ppublish
SO  - Can Vet J. 2011 Sep;52(9):927-8.


PMID- 22378520
OWN - NLM
STAT- MEDLINE
DCOM- 20120716
LR  - 20190911
IS  - 1984-0446 (Electronic)
IS  - 0034-7167 (Linking)
VI  - 64
IP  - 4
DP  - 2011 Jul-Aug
TI  - [The meaning of the profession to students beginning a Nursing undergraduate
      course].
PG  - 725-31
LID - S0034-71672011000400015 [pii]
AB  - This qualitative study aimed to describe the meaning of the profession to
      beginners in a Nursing undergraduate course. A structured interview was
      administered to 33 students of the first semester in a public university in Rio
      de Janeiro, in 2006. Ethical principles were respected. The thematic analysis
      revealed that, when entering the profession, the students visualize nurses as the
      professional who takes care of clients, in a restricted view of care, and
      associate Nursing practice to situations of dedication, care and love. Clarify
      high school students about Nursing, the labor market and Nursing areas of action 
      could stimulate the search of the profession by people more conscious about their
      choice.
FAU - Spindola, Thelma
AU  - Spindola T
AD  - Departamento de Fundamentos de Enfermagem, Faculdade de Enfermagem, Universidade 
      do Estado do Rio de Janeiro, Rio de Janeiro, Brasil. spindola@centroin.com.br
FAU - Santiago, Maria Madalena de Andrade
AU  - Santiago MM
FAU - Martins, Elizabeth Rose da Costa
AU  - Martins ER
FAU - Francisco, Marcio Tadeu Ribeiro
AU  - Francisco MT
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Significado da profissao para alunos que ingressam na graduacao em Enfermagem.
PL  - Brazil
TA  - Rev Bras Enferm
JT  - Revista brasileira de enfermagem
JID - 7910105
MH  - *Attitude
MH  - *Education, Nursing, Baccalaureate
MH  - Humans
MH  - Students, Nursing/*psychology
EDAT- 2012/03/02 06:00
MHDA- 2012/07/17 06:00
CRDT- 2012/03/02 06:00
PHST- 2010/01/19 00:00 [received]
PHST- 2011/08/10 00:00 [accepted]
PHST- 2012/03/02 06:00 [entrez]
PHST- 2012/03/02 06:00 [pubmed]
PHST- 2012/07/17 06:00 [medline]
AID - S0034-71672011000400015 [pii]
AID - 10.1590/s0034-71672011000400015 [doi]
PST - ppublish
SO  - Rev Bras Enferm. 2011 Jul-Aug;64(4):725-31. doi: 10.1590/s0034-71672011000400015.


PMID- 22378515
OWN - NLM
STAT- MEDLINE
DCOM- 20120716
LR  - 20190911
IS  - 1984-0446 (Electronic)
IS  - 0034-7167 (Linking)
VI  - 64
IP  - 4
DP  - 2011 Jul-Aug
TI  - [Therapeutic communication in Nursing: difficulties for the care of elderly
      people with cancer].
PG  - 692-7
LID - S0034-71672011000400010 [pii]
AB  - The objective of this study is to assess the difficulties and their causes, in
      the perception of nurses, to give aid to the old patient bearer oncologic
      pathology. The study, descriptive, used The Critical Incident Technique to the
      obtaining and analyzing of data, complied with the ethical. The subjects were
      nurses, guests, employees of units of cancer care to people aged over 60 years
      and working in oncology for more than a year. The subjects cited 25 critical
      incidents, while 9 situations generated negative feelings, 3 positives and 13
      with double feelings. It was concluded that nurses who reported interventions of 
      human character, showed positive feelings, recognizing how important their
      nursing actions were important to offer human assistance.
FAU - Peterson, Aline Azevedo
AU  - Peterson AA
AD  - Escola de Enfermagem de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao
      Preto, SP, Brasil. alinepeterson@yahoo.com.br
FAU - de Carvalho, Emilia Campos
AU  - de Carvalho EC
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Comunicacao terapeutica na Enfermagem: dificuldades para o cuidar de idosos com
      cancer.
PL  - Brazil
TA  - Rev Bras Enferm
JT  - Revista brasileira de enfermagem
JID - 7910105
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/*nursing
MH  - *Nurse-Patient Relations
MH  - Oncology Nursing/*standards
MH  - Young Adult
EDAT- 2012/03/02 06:00
MHDA- 2012/07/17 06:00
CRDT- 2012/03/02 06:00
PHST- 2010/11/02 00:00 [received]
PHST- 2011/12/05 00:00 [accepted]
PHST- 2012/03/02 06:00 [entrez]
PHST- 2012/03/02 06:00 [pubmed]
PHST- 2012/07/17 06:00 [medline]
AID - S0034-71672011000400010 [pii]
AID - 10.1590/s0034-71672011000400010 [doi]
PST - ppublish
SO  - Rev Bras Enferm. 2011 Jul-Aug;64(4):692-7. doi: 10.1590/s0034-71672011000400010.


PMID- 22378510
OWN - NLM
STAT- MEDLINE
DCOM- 20120716
LR  - 20190911
IS  - 1984-0446 (Electronic)
IS  - 0034-7167 (Linking)
VI  - 64
IP  - 4
DP  - 2011 Jul-Aug
TI  - [The (un)said about AIDS in the quotidian transition from childhood to the
      adolescence].
PG  - 658-64
LID - S0034-71672011000400005 [pii]
AB  - HIV children infected by vertical transmission are crossing from childhood to
      adolescence, however, we do not know how they are caring for themselves during
      those transitional age. The objective was to understand the (un)said about AIDS
      in their quotidian. After approval by the Research Ethics Committee of three
      hospitals in Rio de Janeiro, the interview was conducted with eleven boys/girls
      from 12-14 years old, who knew their diagnosis. The Heideggerian hermeneutics
      unveiled that the adolescent-being knows that the disease was acquired by his/her
      mother; he/she was said that his/her relatives are sick; he/she reminds when the 
      diagnosis was disclosure, and its relation to prejudice. He/she projects him/her 
      as a being-of-possibilities inside an existential movement. One concludes that
      the care for adolescent-being needs to integrate the biological, clinical,
      socio-cultural, ethical, political, and existential dimensions.
FAU - de Paula, Cristiane Cardoso
AU  - de Paula CC
AD  - Departamento de Enfermagem, Universidade Federal de Santa Maria, Santa Maria, RS,
      Brasil. cris_depaula1@hotmail.com
FAU - Cabral, Ivone Evangelista
AU  - Cabral IE
FAU - Souza, Ivis Emilia de Oliveira
AU  - Souza IE
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - O (nao)dito da AIDS no cotidiano de transicao da infancia para a adolescencia.
PL  - Brazil
TA  - Rev Bras Enferm
JT  - Revista brasileira de enfermagem
JID - 7910105
MH  - Acquired Immunodeficiency Syndrome/*psychology
MH  - Adolescent
MH  - Age Factors
MH  - Child
MH  - Female
MH  - Humans
MH  - Infectious Disease Transmission, Vertical
MH  - Male
EDAT- 2012/03/02 06:00
MHDA- 2012/07/17 06:00
CRDT- 2012/03/02 06:00
PHST- 2011/06/08 00:00 [received]
PHST- 2011/10/20 00:00 [accepted]
PHST- 2012/03/02 06:00 [entrez]
PHST- 2012/03/02 06:00 [pubmed]
PHST- 2012/07/17 06:00 [medline]
AID - S0034-71672011000400005 [pii]
AID - 10.1590/s0034-71672011000400005 [doi]
PST - ppublish
SO  - Rev Bras Enferm. 2011 Jul-Aug;64(4):658-64. doi: 10.1590/s0034-71672011000400005.


PMID- 22376386
OWN - NLM
STAT- MEDLINE
DCOM- 20121129
LR  - 20211021
IS  - 1472-6963 (Electronic)
IS  - 1472-6963 (Linking)
VI  - 11 Suppl 2
DP  - 2011 Dec 21
TI  - Proof of impact and pipeline planning: directions and challenges for social audit
      in the health sector.
PG  - S16
LID - 10.1186/1472-6963-11-S2-S16 [doi]
AB  - Social audits are typically observational studies, combining qualitative and
      quantitative uptake of evidence with consultative interpretation of results. This
      often falters on issues of causality because their cross-sectional design limits 
      interpretation of time relations and separation out of other indirect
      associations.Social audits drawing on methods of randomised controlled cluster
      trials (RCCT) allow more certainty about causality. Randomisation means that
      exposure occurs independently of all events that precede it--it converts
      potential confounders and other covariates into random differences. In 2008, CIET
      social audits introduced randomisation of the knowledge translation component
      with subsequent measurement of impact in the changes introduced. This "proof of
      impact" generates an additional layer of evidence in a cost-effective way,
      providing implementation-ready solutions for planners.Pipeline planning is a
      social audit that incorporates stepped wedge RCCTs. From a listing of
      districts/communities as a sampling frame, individual entities (communities,
      towns, districts) are randomly assigned to waves of intervention. Measurement of 
      the impact takes advantage of the delay occasioned by the reality that there are 
      insufficient resources to implement everywhere at the same time. The impact in
      the first wave contrasts with the second wave, which in turn contrasts with a
      third wave, and so on until all have received the intervention. Provided care is 
      taken to achieve reasonable balance in the random allocation of communities,
      towns or districts to the waves, the resulting analysis can be
      straightforward.Where there is sufficient management interest in and commitment
      to evidence, pipeline planning can be integrated in the roll-out of programmes
      where real time information can improve the pipeline. Not all interventions can
      be randomly allocated, however, and random differences can still distort
      measurement. Other issues include contamination of the subsequent waves,
      ambiguity of indicators, "participant effects" that result from lack of blinding 
      and lack of placebos, ethics and, not least important, the skills to do pipeline 
      planning correctly.
FAU - Andersson, Neil
AU  - Andersson N
AD  - Centro de Investigacion de Enfermedades Tropicales, Universidad Autonoma de
      Guerrero, Calle Pino, El Roble, Acapulco, Mexico. andersson@ciet.org
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111221
PL  - England
TA  - BMC Health Serv Res
JT  - BMC health services research
JID - 101088677
SB  - IM
MH  - *Causality
MH  - Delivery of Health Care/*organization & administration
MH  - *Epidemiologic Methods
MH  - Female
MH  - Health Planning/*methods
MH  - Health Services
MH  - Humans
MH  - Maternal Welfare
MH  - Medical Audit/*methods
MH  - Mexico
MH  - Pregnancy
MH  - Pregnancy Complications
MH  - Randomized Controlled Trials as Topic/*methods
MH  - Risk
MH  - Sample Size
PMC - PMC3332560
EDAT- 2012/03/02 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/03/02 06:00
PHST- 2012/03/02 06:00 [entrez]
PHST- 2012/03/02 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 1472-6963-11-S2-S16 [pii]
AID - 10.1186/1472-6963-11-S2-S16 [doi]
PST - epublish
SO  - BMC Health Serv Res. 2011 Dec 21;11 Suppl 2:S16. doi:
      10.1186/1472-6963-11-S2-S16.


PMID- 22375368
OWN - NLM
STAT- MEDLINE
DCOM- 20120405
LR  - 20120301
IS  - 0001-4079 (Print)
IS  - 0001-4079 (Linking)
VI  - 195
IP  - 4-5
DP  - 2011 Apr-May
TI  - [Ethical aspects of preimplantation genetic diagnosis (PGD)].
PG  - 1023-31
AB  - The controversy surrounding PGD has not abated in recent times. This is
      especially the case for PGD-based tissue typing, which is used to select a future
      child who could serve as a stem cell donor for an older sick sibling. We examine 
      three types of ethical argument cited against PGD in general, and specifically
      against tissue-typing PGD. These arguments focus on the moral status of the early
      embryo, the eugenics issue, and the charge that the future child is being
      exploited. We conclude that none of these three arguments is unassailable, and
      that it is the reproductive freedom of couples considering PGD that should
      prevail.
FAU - Mauron, Alex
AU  - Mauron A
AD  - Institut d'ethique biomedicale, Centre medical universitaire, rue Michel-Servet
      1, 1211 Geneve 4, Suisse. alexandre.mauron@unige.ch
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Les aspects ethiques du diagnostic pre-implantatoire (DPI).
PL  - Netherlands
TA  - Bull Acad Natl Med
JT  - Bulletin de l'Academie nationale de medecine
JID - 7503383
SB  - IM
MH  - Eugenics
MH  - Female
MH  - Histocompatibility Testing/ethics
MH  - Humans
MH  - Pregnancy
MH  - Preimplantation Diagnosis/*ethics
EDAT- 2012/03/02 06:00
MHDA- 2012/04/06 06:00
CRDT- 2012/03/02 06:00
PHST- 2012/03/02 06:00 [entrez]
PHST- 2012/03/02 06:00 [pubmed]
PHST- 2012/04/06 06:00 [medline]
PST - ppublish
SO  - Bull Acad Natl Med. 2011 Apr-May;195(4-5):1023-31.


PMID- 22370084
OWN - NLM
STAT- MEDLINE
DCOM- 20120405
LR  - 20120228
IS  - 0995-3914 (Print)
IS  - 0995-3914 (Linking)
VI  - 23 Suppl 6
DP  - 2011 Nov-Dec
TI  - [Prevention and child mental health: the ethical issues raised by targeted
      approaches].
PG  - S181-8
AB  - The details of the implementation of early prevention in child mental health in
      France have been at the heart of a debate between the defenders of a universal
      approach and the proponents of an approach targeting specific populations. The
      universal approach draws on various aspects of mother and child care and early
      childhood care offering considerate and expressive prevention based on a
      relationship of trust developed over time between professionals, parents and
      children. The targeted approach is based on the development of programs aimed at 
      identifying vulnerable or at-risk populations. The ethical issues raised by
      targeted strategies are presented and discussed. The study highlights the
      difficulty of distinguishing between the social, educational, medical and
      psychological issues raised by early prevention.
FAU - Bourdillon, Francois
AU  - Bourdillon F
AD  - Departement de bio-statistiques, Groupe Hospitalier Pitie-Salpetriere, Paris.
FAU - Lenoble, Evelyne
AU  - Lenoble E
FAU - Giampino, Sylviane
AU  - Giampino S
FAU - Suesser, Pierre
AU  - Suesser P
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Prevention et sante mentale de l'enfant : les questions ethiques soulevees par
      des approches ciblees.
PL  - France
TA  - Sante Publique
JT  - Sante publique (Vandoeuvre-les-Nancy, France)
JID - 9216153
SB  - IM
MH  - Child
MH  - Child Behavior Disorders/*prevention & control/psychology
MH  - Child Guidance
MH  - *Child Health Services
MH  - Child Psychiatry/*ethics
MH  - France
MH  - Humans
MH  - Juvenile Delinquency/*prevention & control
MH  - Mental Health Services
EDAT- 2012/03/01 06:00
MHDA- 2012/04/06 06:00
CRDT- 2012/02/29 06:00
PHST- 2012/02/29 06:00 [entrez]
PHST- 2012/03/01 06:00 [pubmed]
PHST- 2012/04/06 06:00 [medline]
PST - ppublish
SO  - Sante Publique. 2011 Nov-Dec;23 Suppl 6:S181-8.


PMID- 22369012
OWN - NLM
STAT- MEDLINE
DCOM- 20120320
LR  - 20120228
IS  - 0354-950X (Print)
IS  - 0354-950X (Linking)
VI  - 58
IP  - 3
DP  - 2011
TI  - [Hippocratic Oath: professional or ethic code?].
PG  - 9-14; discussion 14
AB  - In order to study the historical relationship of early medical professional codex
      and contemporary demands and challenges, which are currently being placed before 
      physicians, the first such text, known as Hippocratic Oath has been
      re-translated. According to the source, it is clear that this is a Code of
      professional conduct, primarily for the welfare of patients, and in order to
      maintain and preserve medical authority. All parts of the Oath have been
      discussed and presented, as well as the historical data from which one can see
      how the system in ancient Greece and Rome worked. The study includes historical
      data from that time on two controversial issues: the liability of medical awards,
      and addressing medical services. These are mistakenly considered to belong to the
      text of the Oath. Examples of the amount of medical awards are stated, as well as
      the examples of selflessness and dedication of the physicians in that time. A
      physician was obliged to help by law, only in the case of accidents and injuries.
      It is obvious that "medical doctrine" existed also in this time. Requirements set
      to a doctor were realistic, modest and appropriate to the call, with the main
      purpose of protecting the reputation and dignity of the profession. Despite the
      historical distance, classical text of the Oath is still up to date. In this
      context, ambiguities and errors result from not being familiar with the both, the
      basic text, and the circumstances prevailing at the time and society, in which
      the Oath was made.
FAU - Popovic, Milos
AU  - Popovic M
AD  - Klinika za digestivnu hirurgiju Prva hirurska klinika KCS Beograd.
LA  - srp
PT  - English Abstract
PT  - Historical Article
PT  - Journal Article
PL  - Serbia
TA  - Acta Chir Iugosl
JT  - Acta chirurgica Iugoslavica
JID - 0372631
SB  - IM
MH  - Codes of Ethics/history
MH  - Ethics, Medical/*history
MH  - Greek World
MH  - *Hippocratic Oath
MH  - History, Ancient
MH  - Humans
MH  - Philosophy, Medical/history
MH  - Roman World
EDAT- 2012/03/01 06:00
MHDA- 2012/03/21 06:00
CRDT- 2012/02/29 06:00
PHST- 2012/02/29 06:00 [entrez]
PHST- 2012/03/01 06:00 [pubmed]
PHST- 2012/03/21 06:00 [medline]
PST - ppublish
SO  - Acta Chir Iugosl. 2011;58(3):9-14; discussion 14.


PMID- 22368458
OWN - NLM
STAT- MEDLINE
DCOM- 20120613
LR  - 20220408
IS  - 1424-8220 (Electronic)
IS  - 1424-8220 (Linking)
VI  - 12
IP  - 1
DP  - 2012
TI  - Security issues in healthcare applications using wireless medical sensor
      networks: a survey.
PG  - 55-91
LID - 10.3390/s120100055 [doi]
AB  - Healthcare applications are considered as promising fields for wireless sensor
      networks, where patients can be monitored using wireless medical sensor networks 
      (WMSNs). Current WMSN healthcare research trends focus on patient reliable
      communication, patient mobility, and energy-efficient routing, as a few examples.
      However, deploying new technologies in healthcare applications without
      considering security makes patient privacy vulnerable. Moreover, the
      physiological data of an individual are highly sensitive. Therefore, security is 
      a paramount requirement of healthcare applications, especially in the case of
      patient privacy, if the patient has an embarrassing disease. This paper discusses
      the security and privacy issues in healthcare application using WMSNs. We
      highlight some popular healthcare projects using wireless medical sensor
      networks, and discuss their security. Our aim is to instigate discussion on these
      critical issues since the success of healthcare application depends directly on
      patient security and privacy, for ethic as well as legal reasons. In addition, we
      discuss the issues with existing security mechanisms, and sketch out the
      important security requirements for such applications. In addition, the paper
      reviews existing schemes that have been recently proposed to provide security
      solutions in wireless healthcare scenarios. Finally, the paper ends up with a
      summary of open security research issues that need to be explored for future
      healthcare applications using WMSNs.
FAU - Kumar, Pardeep
AU  - Kumar P
AD  - Department of Ubiquitous-IT, Graduate School of Design & IT, Dongseo University, 
      San 69-1, Jurye-2-Dong, Sasang-Gu, Busan 617-716, Korea. pradeepkhl@gmail.com
FAU - Lee, Hoon-Jae
AU  - Lee HJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20111222
PL  - Switzerland
TA  - Sensors (Basel)
JT  - Sensors (Basel, Switzerland)
JID - 101204366
SB  - IM
MH  - Computer Communication Networks/*instrumentation/legislation & jurisprudence
MH  - *Computer Security/legislation & jurisprudence
MH  - *Data Collection
MH  - Delivery of Health Care/legislation & jurisprudence/*methods
MH  - Electronics, Medical/*instrumentation/legislation & jurisprudence
MH  - Wireless Technology/*instrumentation/legislation & jurisprudence
PMC - PMC3279202
OTO - NOTNLM
OT  - *healthcare applications
OT  - *healthcare security issues
OT  - *medical sensor networks
OT  - *patient privacy issues
OT  - *wireless body area network
OT  - *wireless sensor network
EDAT- 2012/03/01 06:00
MHDA- 2012/06/14 06:00
CRDT- 2012/02/28 06:00
PHST- 2011/11/21 00:00 [received]
PHST- 2011/12/07 00:00 [revised]
PHST- 2011/12/15 00:00 [accepted]
PHST- 2012/02/28 06:00 [entrez]
PHST- 2012/03/01 06:00 [pubmed]
PHST- 2012/06/14 06:00 [medline]
AID - 10.3390/s120100055 [doi]
AID - s120100055 [pii]
PST - ppublish
SO  - Sensors (Basel). 2012;12(1):55-91. doi: 10.3390/s120100055. Epub 2011 Dec 22.


PMID- 22360105
OWN - NLM
STAT- MEDLINE
DCOM- 20120309
LR  - 20220316
IS  - 0746-1739 (Print)
IS  - 0746-1739 (Linking)
VI  - 29
IP  - 6
DP  - 2011 Nov-Dec
TI  - Internationally educated nurse hiring: geographic distribution, community, and
      hospital characteristics.
PG  - 308-16
AB  - As the largest importer of internationally educated nurses (IENs), the United
      States is considered to be the epicenter of global nurse migration. The purposes 
      of this study were to examine the geographic distribution of IEN hiring and
      determine associations between community and hospital characteristics and IEN
      hiring. More community characteristics than hospital characteristics were
      strongly associated with IEN hiring which suggest perceived community needs and
      receptivity to lENs could be an important consideration in hospital
      administrators' decisions to hire IENs. These findings suggest that as the U.S.
      population ages and becomes increasingly diverse, the demand for IENs is likely
      to grow. Nurse leaders and faculty may face challenges with regard to the ethical
      recruitment of IENs from low-income countries, incorporation of IENs into U.S.
      health care organizations, and continued development of a diverse U.S.-educated
      nursing workforce. This study expands understanding of the demand side of IEN
      employment in U.S. hospitals by providing the first in-depth examination of the
      community and hospital factors related to hospitals' IEN hiring.
FAU - Cho, Sung-Hyun
AU  - Cho SH
AD  - Department of Nursing, Hanyang University, Seoul, Korea.
FAU - Masselink, Leah E
AU  - Masselink LE
FAU - Jones, Cheryl B
AU  - Jones CB
FAU - Mark, Barbara A
AU  - Mark BA
LA  - eng
GR  - T32 NR008856/NR/NINR NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Nurs Econ
JT  - Nursing economic$
JID - 8404213
MH  - Geography
MH  - *Hospitals, Community
MH  - *Internationality
MH  - *Nurses
MH  - *Personnel Selection
MH  - United States
MH  - Workforce
PMC - PMC4349421
MID - NIHMS666488
EDAT- 2012/03/01 06:00
MHDA- 2012/03/10 06:00
CRDT- 2012/02/25 06:00
PHST- 2012/02/25 06:00 [entrez]
PHST- 2012/03/01 06:00 [pubmed]
PHST- 2012/03/10 06:00 [medline]
PST - ppublish
SO  - Nurs Econ. 2011 Nov-Dec;29(6):308-16.


PMID- 31052015
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1876-7982 (Electronic)
IS  - 1876-7982 (Linking)
VI  - 43
IP  - 1
DP  - 2012 Mar
TI  - The Use of Journal Clubs in Canadian Radiation Therapy Departments: Prevalence
      and Perceptions.
PG  - 16-25
LID - 10.1016/j.jmir.2011.07.001 [doi]
AB  - BACKGROUND: Public debate of published research in a journal club (JC) setting
      keeps professionals abreast of new knowledge and promotes excellent clinical
      practice. These skills have become increasingly important for radiation
      therapists (RTs), but the extent of their participation in JC activities is
      unknown. Therefore, this study was performed to determine the prevalence of JCs
      within the Canadian RT community and describe RTs' perceptions of this learning
      opportunity. MATERIALS AND METHODS: After Research Ethics Board (REB) approval, a
      prospective, multicenter two-phase project was performed. First, a questionnaire 
      was distributed by e-mail to representatives of all radiotherapy departments in
      Canada. This questionnaire determined whether a JC was available to the RTs and
      the approximate number of RT attendees. Second, an online questionnaire was
      distributed to all RTs in the departments with a JC. This questionnaire asked
      both attendees and nonattendees for their opinions on JC participation. As all
      questionnaires and evaluation forms were designed specifically for this research,
      each tool was piloted and validated prior to data collection. RESULTS: Fifteen
      replies (43%) were received from 35 Canadian radiotherapy departments, with 5 of 
      these departments holding a JC that RTs could attend. Seven of the remaining
      departments would consider organizing a JC, but lack of staff interest or time
      prevented them from doing so. Approximately 5% of RTs attended any single JC
      meeting. Seventy-one responses (18%) were received from the RTs who worked in a
      clinic with a JC. Primarily, RTs attended JC because they were interested in the 
      article (40%), and did not attend from lack of time (60%). JC attendees cited
      improvements in critical analysis skills and increased volume of scientific
      reading. More than half the nonattendees also read the JC article. CONCLUSIONS:
      The prevalence of JCs available to Canadian RTs was low compared to those of
      other professions. When RTs did attend, however, their levels of participation
      and satisfaction were very high. JC was credited with improving critical analysis
      skills and the volume of reading done by its participants.
CI  - Copyright A(c) 2012 Elsevier Inc. All rights reserved.
FAU - Rosewall, Tara
AU  - Rosewall T
AD  - Radiation Medicine Program, Princess Margaret Hospital, Toronto, Canada;
      Department of Radiation Oncology, University of Toronto, Canada.
LA  - eng
PT  - Journal Article
DEP - 20110925
PL  - United States
TA  - J Med Imaging Radiat Sci
JT  - Journal of medical imaging and radiation sciences
JID - 101469694
EDAT- 2012/03/01 00:00
MHDA- 2012/03/01 00:01
CRDT- 2019/05/05 06:00
PHST- 2011/03/28 00:00 [received]
PHST- 2011/07/07 00:00 [revised]
PHST- 2011/07/11 00:00 [accepted]
PHST- 2019/05/05 06:00 [entrez]
PHST- 2012/03/01 00:00 [pubmed]
PHST- 2012/03/01 00:01 [medline]
AID - S1939-8654(11)00064-6 [pii]
AID - 10.1016/j.jmir.2011.07.001 [doi]
PST - ppublish
SO  - J Med Imaging Radiat Sci. 2012 Mar;43(1):16-25. doi: 10.1016/j.jmir.2011.07.001. 
      Epub 2011 Sep 25.


PMID- 22359423
OWN - NLM
STAT- MEDLINE
DCOM- 20120727
LR  - 20211021
IS  - 2616-163X (Electronic)
IS  - 0016-9560 (Linking)
VI  - 45
IP  - 4
DP  - 2011 Dec
TI  - The medico-legal prerequisite for initiating quarantine and isolation practices
      in public health emergency management in hospitals in Ghana.
PG  - 167-73
AB  - Hospitals and other health facilities in Ghana do not appear to have standardized
      practices for quarantine and isolation in public health emergency management.
      This paper reviews the legislative framework governing the medico-legal
      prerequisites for initiating quarantine and isolation procedures as articulated
      in the Infectious Disease Act (Cap 78) 1908 amended, 1935, the Quarantine Act
      (Cap 77) 1915 amended, 1938, the Emergency Powers Act of 1994, (Act 472), and the
      National Disaster Management Act, 1996, (Act 517) in consonance with the 1992
      Constitution of Ghana. The findings provide that (1) The legislative framework
      outlines systematic standards and protocols to be followed in the committal of
      person or persons in quarantine and isolation during public health emergencies.
      (2) These standards and protocols consider as imperative, the creation of
      standardized national templates for the initiation of quarantine and isolation
      measures. (3) The non-compliance of the standards and protocols renders
      vulnerable medical facilities and hospitals with their personnel to the threat of
      medical malpractice suits and breach of professional ethics. This paper provides 
      suggestions to hospital administrators and medical personnel of how to develop
      administrative templates in compliance with the law in managing public health
      emergencies. It also provides examples of such templates for possible adoption by
      hospitals and other health administrators.
FAU - Norman, I D
AU  - Norman ID
AD  - Department of Biological, Environmental and Occupational Health Science, School
      of Public Health, University of Ghana, PO Box LG 13, Legon, Accra, Ghana.
      ishmael_norman@yahoo.com
FAU - Aikins, M
AU  - Aikins M
FAU - Binka, F N
AU  - Binka FN
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Ghana
TA  - Ghana Med J
JT  - Ghana medical journal
JID - 0073210
SB  - IM
MH  - *Emergencies
MH  - Ghana
MH  - Government Regulation
MH  - Guideline Adherence
MH  - Humans
MH  - *Legislation, Hospital
MH  - Patient Isolation/*legislation & jurisprudence/standards
MH  - Practice Guidelines as Topic
MH  - Public Health/legislation & jurisprudence/standards
MH  - Quarantine/*legislation & jurisprudence/standards
PMC - PMC3283096
OTO - NOTNLM
OT  - Administrators
OT  - Hospitals
OT  - Isolation
OT  - Procedures
OT  - Public Health Emergency Management
OT  - Quarantine
EDAT- 2012/02/24 06:00
MHDA- 2012/07/28 06:00
CRDT- 2012/02/24 06:00
PHST- 2012/02/24 06:00 [entrez]
PHST- 2012/02/24 06:00 [pubmed]
PHST- 2012/07/28 06:00 [medline]
PST - ppublish
SO  - Ghana Med J. 2011 Dec;45(4):167-73.


PMID- 22357490
OWN - NLM
STAT- MEDLINE
DCOM- 20130107
LR  - 20120223
IS  - 1001-9391 (Print)
IS  - 1001-9391 (Linking)
VI  - 29
IP  - 10
DP  - 2011 Oct
TI  - [Investigating the treatment of silicosis with autologous bone marrow-derived
      mesenchymal stem cells].
PG  - 751-5
AB  - OBJECTIVE: To explore the safety and curative effects of autologous bone
      marrow-derived mesenchymal stem cells (BMSCs) in the treatment of silicosis.
      METHODS: The protocol was approved by the Ethics Committee of the hospital, and
      ten patients with silicosis who had given written consent were enrolled in this
      study. BMSCs isolated from 100 ml of bone marrow for each case were purified and 
      cultured. In each case the 3rd generation of qualified BMSCs (5 x 10(7)) were
      intravenously administered weekly for 3 weeks. Three cases among 10 patients were
      treated with BMSCs modified by hepatocyte growth factor (HGF) gene. The clinical 
      symptoms, chest films, chest CT, pulmonary functions, T cells, serum IgG and
      ceruloplasmin (CP) were observed in 6 or 9 months after treatment. RESULTS: No
      obvious sub-effect was observed in cases treated with BMSCs, the clinical
      symptoms (such as cough, sputum and chest tightness) basically disappeared in 9
      months after treatment. Pulmonary function tests showed that FVC increased from
      71.2% +/- 17.0% to 84.0% +/- 10.9% (P < 0.01) and FEV1.0 increased from 67.5% +/-
      17.7% to 80.6% +/- 14.9% (P < 0.01). The levels of serum CP and IgG significantly
      decreased (P < 0.01). Further, the chest films and CT in cases treated with
      autologous BMSCs modified by HGF gene were improved to different extent.
      CONCLUSION: Treatment with autologous BMSCs modified by HGF gene exhibit a
      beneficial effect on silicosis.
FAU - Chen, Ling-zhen
AU  - Chen LZ
AD  - Guangzhou No. 12 Hospital, Guangzhou 510620, China.
FAU - Liu, Wei-wei
AU  - Liu WW
FAU - Chen, Jia-yu
AU  - Chen JY
FAU - Yu, Wei
AU  - Yu W
FAU - Ye, Geng-xin
AU  - Ye GX
FAU - Zhan, Yu
AU  - Zhan Y
FAU - Wu, Jin-ming
AU  - Wu JM
FAU - Guo, Zi-kuan
AU  - Guo ZK
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - China
TA  - Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
JT  - Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng
      zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases
JID - 8410840
RN  - 67256-21-7 (Hepatocyte Growth Factor)
SB  - IM
MH  - Adult
MH  - Bone Marrow Cells
MH  - Female
MH  - Hepatocyte Growth Factor/*genetics
MH  - Humans
MH  - Male
MH  - Mesenchymal Stem Cell Transplantation/*methods
MH  - Middle Aged
MH  - Silicosis/*surgery
MH  - Transfection
MH  - Transplantation, Autologous
MH  - Treatment Outcome
EDAT- 2012/02/24 06:00
MHDA- 2013/01/08 06:00
CRDT- 2012/02/24 06:00
PHST- 2012/02/24 06:00 [entrez]
PHST- 2012/02/24 06:00 [pubmed]
PHST- 2013/01/08 06:00 [medline]
PST - ppublish
SO  - Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2011 Oct;29(10):751-5.


PMID- 22356017
OWN - NLM
STAT- MEDLINE
DCOM- 20120424
LR  - 20151119
IS  - 0030-9982 (Print)
IS  - 0030-9982 (Linking)
VI  - 61
IP  - 8
DP  - 2011 Aug
TI  - Awareness about organ donation especially kidney donation in Nurpur Shahan, a
      rural community area in Islamabad, Pakistan.
PG  - 828-32
AB  - OBJECTIVE: To assess the level of awareness and ethical issues related to organ
      donation especially kidney donation and the willingness to donate a kidney among 
      the rural population of Pakistan. METHOD: A cross sectional study was conducted
      in a sample of 324 subjects residing in Nurpur Shahan by means of a pre tested
      questionnaire. Data collection was carried out via a face to face interview and
      the data was analyzed using SPSS 10.0 and associations were tested using the
      Chi-square test. RESULTS: Knowledge about organ donation was significantly
      associated with age (p = 0.00) and education (p = 0.024). Allowance of organ
      donation in religion was an important factor in determining the attitude of
      individuals towards organ donation and their willingness to donate. Media emerged
      as a major source of information for the population of Nurpur Shahan; kidney was 
      the organ most known for its donation. Most (69%) respondents did not consider
      organ vending to be ethically correct but a sizeable proportion (25%) thought it 
      may be considered in times of dire need. CONCLUSION: Awareness of organ donation 
      in our sample was high and more than half of the people were willing to become
      donors.
FAU - Maroof, Sana
AU  - Maroof S
AD  - Shifa College of Medicine, Islamabad, Pakistan.
FAU - Kiyani, Nimrah
AU  - Kiyani N
FAU - Zaman, Zahra
AU  - Zaman Z
FAU - Gul, Raisa Khan
AU  - Gul RK
FAU - Nayyar, Sarah
AU  - Nayyar S
FAU - Azmat, Ayesha
AU  - Azmat A
FAU - Anwar, Nageen
AU  - Anwar N
FAU - Shah, Rahim
AU  - Shah R
FAU - Iqbal, Saima
AU  - Iqbal S
FAU - Junaid, Aliya
AU  - Junaid A
LA  - eng
PT  - Journal Article
PL  - Pakistan
TA  - J Pak Med Assoc
JT  - JPMA. The Journal of the Pakistan Medical Association
JID - 7501162
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Awareness
MH  - Cross-Sectional Studies
MH  - Culture
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Interviews as Topic
MH  - Kidney
MH  - Kidney Transplantation/*psychology
MH  - Male
MH  - Middle Aged
MH  - Pakistan
MH  - *Rural Population
MH  - Socioeconomic Factors
MH  - Surveys and Questionnaires
MH  - Tissue Donors/*psychology
MH  - *Tissue and Organ Procurement
MH  - Young Adult
EDAT- 2012/02/24 06:00
MHDA- 2012/04/25 06:00
CRDT- 2012/02/24 06:00
PHST- 2012/02/24 06:00 [entrez]
PHST- 2012/02/24 06:00 [pubmed]
PHST- 2012/04/25 06:00 [medline]
AID - 2944 [pii]
PST - ppublish
SO  - J Pak Med Assoc. 2011 Aug;61(8):828-32.


PMID- 22356000
OWN - NLM
STAT- MEDLINE
DCOM- 20120424
LR  - 20151119
IS  - 0030-9982 (Print)
IS  - 0030-9982 (Linking)
VI  - 61
IP  - 8
DP  - 2011 Aug
TI  - Medical students' perspectives on gender and smoking: a mixed methodology
      investigation in Karachi, Pakistan.
PG  - 773-8
AB  - OBJECTIVE: To explore the gender dimensions on influences of tobacco uptake on
      medical students using both qualitative and quantitative methods. METHODS: A
      phased mixed-method study design was used with in-depth interviews followed by a 
      survey questionnaire in a 'smoke-free' medical college campus in a private
      university of Karachi. Eight in-depth interviews were conducted to under-pin
      themes that were further used for developing the questionnaire. Tabulation and
      analysis of the quantitative data was done using SPSS software version 12. All
      the ethical issues for the research were taken into consideration. RESULTS: One
      hundred and sixty-five (72 male, 93 female) students participated in the study.
      Mean age was 21.57 +/- 1.66 years. The survey results reported perceived reasons 
      for male smoking as stress relief (74%), image (62%), companionship (54%),
      leisurely independence (46%) and male power and masculinity (44%). Among reasons 
      for women for not smoking by the majority was that it was frowned upon (87%)
      while the reasons for smoking clustered around concepts of images (65%), western 
      culture (66%), stress relief (51%) and advertising (36%). A large proportion
      (55%) of students felt bad and bothered by male and female smoking. CONCLUSION:
      Despite being medical students, the anti-tobacco future role models, traditional 
      concepts of gender were frequently involved that explains smoking and non-smoking
      gendered behaviours.
FAU - Mubeen, Syed Muhammad
AU  - Mubeen SM
AD  - Department of Community Health Sciences, Hamdard College of Medicine & Dentistry,
      Hamdard University, Karachi, Pakistan.
FAU - Morrow, Martha
AU  - Morrow M
FAU - Barraclough, Simon
AU  - Barraclough S
LA  - eng
PT  - Journal Article
PL  - Pakistan
TA  - J Pak Med Assoc
JT  - JPMA. The Journal of the Pakistan Medical Association
JID - 7501162
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Attitude to Health
MH  - Culture
MH  - Female
MH  - Gender Identity
MH  - Health Surveys
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Pakistan
MH  - Perception
MH  - Qualitative Research
MH  - Sex Distribution
MH  - *Smoking
MH  - Students, Medical/*psychology/statistics & numerical data
MH  - Surveys and Questionnaires
MH  - *Tobacco
EDAT- 2012/02/24 06:00
MHDA- 2012/04/25 06:00
CRDT- 2012/02/24 06:00
PHST- 2012/02/24 06:00 [entrez]
PHST- 2012/02/24 06:00 [pubmed]
PHST- 2012/04/25 06:00 [medline]
AID - 2926 [pii]
PST - ppublish
SO  - J Pak Med Assoc. 2011 Aug;61(8):773-8.


PMID- 22355987
OWN - NLM
STAT- MEDLINE
DCOM- 20120424
LR  - 20120223
IS  - 0030-9982 (Print)
IS  - 0030-9982 (Linking)
VI  - 61
IP  - 8
DP  - 2011 Aug
TI  - Code of conduct and ethical teaching in medical profession.
PG  - 721-2
FAU - Thahim, Kalimullah
AU  - Thahim K
LA  - eng
PT  - Editorial
PL  - Pakistan
TA  - J Pak Med Assoc
JT  - JPMA. The Journal of the Pakistan Medical Association
JID - 7501162
SB  - IM
MH  - *Codes of Ethics
MH  - Curriculum
MH  - *Education, Medical
MH  - *Ethics, Professional
MH  - Humans
MH  - Teaching
EDAT- 2012/02/24 06:00
MHDA- 2012/04/25 06:00
CRDT- 2012/02/24 06:00
PHST- 2012/02/24 06:00 [entrez]
PHST- 2012/02/24 06:00 [pubmed]
PHST- 2012/04/25 06:00 [medline]
AID - 2913 [pii]
PST - ppublish
SO  - J Pak Med Assoc. 2011 Aug;61(8):721-2.


PMID- 22355829
OWN - HMD
STAT- MEDLINE
DCOM- 20120614
LR  - 20191210
IS  - 0042-5222 (Print)
IS  - 0042-5222 (Linking)
VI  - 53
IP  - 4
DP  - 2011
TI  - Imperial boyhood: piracy and the play ethic.
PG  - 689-714
AB  - Representations of perpetual boyhood came to fascinate the late Victorians,
      partly because such images could naturalize a new spirit of imperial aggression
      and new policies of preserving power. This article traces the emergence of this
      fantasy through a series of stories about the relationship of the boy and the
      pirate, figures whose opposition in mid-Victorian literature was used to
      articulate the moral legitimacy of colonialism, but who became doubles rather
      than antitheses in later novels, such as R.L. Stevenson's "Treasure Island" and
      Joseph Conrad's "Lord Jim." Masculine worth needed no longer to be measured by
      reference to transcendent, universal laws, but by a morally flexible ethic of
      competitive play, one that bound together boyishness and piracy in a satisfying
      game of international adventure.
FAU - Deane, Bradley
AU  - Deane B
AD  - University of Minnesota, Morris.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - Vic Stud
JT  - Victorian studies
JID - 9426344
MH  - Aggression/physiology/psychology
MH  - *Child
MH  - *Colonialism/history
MH  - *Competitive Behavior/physiology
MH  - Fantasy
MH  - Hierarchy, Social/history
MH  - History, 19th Century
MH  - History, 20th Century
MH  - Humans
MH  - *Literature/history
MH  - Male
MH  - Masculinity/history
MH  - *Morals
MH  - *Play and Playthings/psychology
MH  - *Power, Psychological
MH  - United Kingdom/ethnology
EDAT- 2012/02/24 06:00
MHDA- 2012/06/15 06:00
CRDT- 2012/02/24 06:00
PHST- 2012/02/24 06:00 [entrez]
PHST- 2012/02/24 06:00 [pubmed]
PHST- 2012/06/15 06:00 [medline]
AID - 10.2979/victorianstudies.53.4.689 [doi]
PST - ppublish
SO  - Vic Stud. 2011;53(4):689-714. doi: 10.2979/victorianstudies.53.4.689.


PMID- 22355828
OWN - HMD
STAT- MEDLINE
DCOM- 20120614
LR  - 20191112
IS  - 0042-5222 (Print)
IS  - 0042-5222 (Linking)
VI  - 53
IP  - 4
DP  - 2011
TI  - On suffering and sympathy: "Jude the Obscure," evolution, and ethics.
PG  - 665-87
AB  - This article links Thomas Hardy's exploration of sympathy in "Jude the Obscure"
      to contemporary scientific debates over moral evolution. Tracing the relationship
      between pessimism, progressivism, and determinism in Hardy's understanding of
      sympathy, it also considers Hardy's conception of the author as enlarger of
      'social sympathies' - a position, I argue, that was shaped by Leslie Stephen's
      advocacy of novel writing as moral art. Considering Hardy's engagement with
      writings by Charles Darwin, T.H. Huxley, Herbert Spencer, and others, I explore
      the novel's participation in a debate about the evolutionary significance of
      sympathy and its implications for Hardy's understanding of moral agency. Hardy, I
      suggest, offered a stronger defence of morality based on biological determinism
      than Darwin, but this determinism was linked to an unexpected evolutionary
      optimism.
FAU - Sumpter, Caroline
AU  - Sumpter C
AD  - Queen's University, Belfast.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - Vic Stud
JT  - Victorian studies
JID - 9426344
MH  - *Ethics/history
MH  - *Evolution, Molecular
MH  - *Expressed Emotion
MH  - Genetic Determinism
MH  - History, 19th Century
MH  - *Literature/history
MH  - *Morals
MH  - Social Perception
MH  - Social Values/ethnology/history
MH  - *Stress, Psychological/ethnology/history
MH  - United Kingdom/ethnology
EDAT- 2012/02/24 06:00
MHDA- 2012/06/15 06:00
CRDT- 2012/02/24 06:00
PHST- 2012/02/24 06:00 [entrez]
PHST- 2012/02/24 06:00 [pubmed]
PHST- 2012/06/15 06:00 [medline]
AID - 10.2979/victorianstudies.53.4.665 [doi]
PST - ppublish
SO  - Vic Stud. 2011;53(4):665-87. doi: 10.2979/victorianstudies.53.4.665.


PMID- 22355442
OWN - NLM
STAT- MEDLINE
DCOM- 20120619
LR  - 20211021
IS  - 1937-8688 (Electronic)
VI  - 9
DP  - 2011
TI  - A Kenyan perspective on the use of animals in science education and scientific
      research in Africa and prospects for improvement.
PG  - 45
AB  - INTRODUCTION: Animal experimentation is common in Africa, a region that accords
      little priority on animal protection in comparison to economic and social
      development. The current study aimed at investigating the prevalence of animal
      experimentation in Kenya, and to review shortfalls in policy, legislation,
      implementation and enforcement that result in inadequate animal care in Kenya and
      other African nations. METHODS: Data was collected using questionnaires,
      administered at 39 highly ranked academic and research institutions aiming to
      identify those that used animals, their sources of animals, and application of
      the three Rs. Perceived challenges to the use of non-animal alternatives and
      common methods of euthanasia were also queried. Data was analyzed using Epidata, 
      SPSS 16.0 and Microsoft Excel. RESULTS: Thirty-eight (97.4%) of thirty-nine
      institutions reported using animals for education and/or research. Thirty (76.9%)
      institutions reported using analgesics or anesthetics on a regular basis.
      Thirteen (33.3%) institutions regularly used statistical methods to minimize the 
      use of animals. Overall, sixteen (41.0%) institutions explored the use of
      alternatives to animals such as cell cultures and computer simulation techniques,
      with one (2.6%) academic institution having completely replaced animals with
      computer modeling, manikins and visual illustrations. The commonest form of
      euthanasia employed was chloroform administration, reportedly in fourteen (29.8%)
      of 47 total methods (some institutions used more than one method). Twenty-eight
      (71.8%) institutions had no designated ethics committee to review or monitor
      protocols using animals. CONCLUSION: Animals are commonly used in academic and
      research institutions in Kenya. The relative lack of ethical guidance and
      oversight regarding the use of animals in research and education presents
      significant concerns.
FAU - Kimwele, Charles
AU  - Kimwele C
AD  - Department of Veterinary Anatomy and Physiology, University of Nairobi, Kenya.
FAU - Matheka, Duncan
AU  - Matheka D
FAU - Ferdowsian, Hope
AU  - Ferdowsian H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110825
PL  - Uganda
TA  - Pan Afr Med J
JT  - The Pan African medical journal
JID - 101517926
SB  - IM
MH  - Academies and Institutes/statistics & numerical data
MH  - Analgesia/veterinary
MH  - Animal Care Committees/statistics & numerical data/trends
MH  - Animal Experimentation/*ethics/legislation & jurisprudence/standards/statistics &
      numerical data
MH  - Animal Use Alternatives/statistics & numerical data
MH  - Animal Welfare/*legislation & jurisprudence/standards
MH  - Animals
MH  - Animals, Laboratory
MH  - Chickens
MH  - Data Collection
MH  - Euthanasia, Animal
MH  - Fishes
MH  - Humans
MH  - Kenya
MH  - Mammals
MH  - Research/legislation & jurisprudence/*standards
MH  - Schools/statistics & numerical data
MH  - Science/*education
MH  - Surveys and Questionnaires
PMC - PMC3215567
OTO - NOTNLM
OT  - Africa
OT  - Alternatives
OT  - Animal Research
OT  - Education
OT  - Ethics
OT  - Experimentation
OT  - Kenya
OT  - Three Rs
EDAT- 2012/02/23 06:00
MHDA- 2012/06/20 06:00
CRDT- 2012/02/23 06:00
PHST- 2011/04/05 00:00 [received]
PHST- 2011/08/16 00:00 [accepted]
PHST- 2012/02/23 06:00 [entrez]
PHST- 2012/02/23 06:00 [pubmed]
PHST- 2012/06/20 06:00 [medline]
AID - 10.4314/pamj.v9i1.71224 [doi]
PST - ppublish
SO  - Pan Afr Med J. 2011;9:45. doi: 10.4314/pamj.v9i1.71224. Epub 2011 Aug 25.


PMID- 22355436
OWN - NLM
STAT- MEDLINE
DCOM- 20120619
LR  - 20211021
IS  - 1937-8688 (Electronic)
VI  - 9
DP  - 2011
TI  - An exploratory study of the views of Ugandan women and health practitioners on
      the use of sonography to establish fetal sex.
PG  - 36
AB  - INTRODUCTION: Ultrasound is now part of routine care for pregnant women in
      Uganda, and is one of a range of techniques used in screening during pregnancy.
      However, it differs from most others screening procedures because it allows women
      to view their babies. Unfortunately, the recipients of this technology are seldom
      asked about it. This study aimed at finding out the knowledge, attitudes and
      practices of pregnant women towards prenatal sonography. METHODS: The study was
      exploratory and descriptive, using interviewer-administered questionnaires.
      Thematic analysis was employed. RESULTS: The health professionals interviewed
      discouraged the idea of disclosing fetal sex unless it is justifiably indicated
      for medical reasons. However, the women in this study supported the idea of being
      told the sex of the baby in order to plan for the necessary items they need.
      CONCLUSION: There is need for a policy to be made not to disclose fetal sex to
      parents as this raises numerous ethical concerns. Health workers, women and the
      general public need to be sensitized about the dangers of this practice as well.
FAU - Mubuuke, Aloysius Gonzaga
AU  - Mubuuke AG
AD  - Radiology Department, School of Medicine, College of Health Sciences, Makerere
      University, Kampala, Uganda.
LA  - eng
PT  - Journal Article
DEP - 20110801
PL  - Uganda
TA  - Pan Afr Med J
JT  - The Pan African medical journal
JID - 101517926
SB  - IM
MH  - Abortion, Legal/*ethics
MH  - Adult
MH  - *Attitude
MH  - *Attitude of Health Personnel
MH  - Cross-Sectional Studies
MH  - False Negative Reactions
MH  - False Positive Reactions
MH  - Female
MH  - Health Personnel/*psychology
MH  - Humans
MH  - Pilot Projects
MH  - Pregnancy
MH  - Pregnancy, Unwanted/psychology
MH  - Prejudice
MH  - Sex Determination Analysis/*ethics
MH  - Sex Preselection/*ethics
MH  - Truth Disclosure/ethics
MH  - Uganda
MH  - Ultrasonography, Prenatal/ethics/*psychology
MH  - Women/*psychology
PMC - PMC3215558
OTO - NOTNLM
OT  - Fetal sex
OT  - Uganda
OT  - sonography
EDAT- 2012/02/23 06:00
MHDA- 2012/06/20 06:00
CRDT- 2012/02/23 06:00
PHST- 2011/04/27 00:00 [received]
PHST- 2011/08/01 00:00 [accepted]
PHST- 2012/02/23 06:00 [entrez]
PHST- 2012/02/23 06:00 [pubmed]
PHST- 2012/06/20 06:00 [medline]
AID - 10.4314/pamj.v9i1.71214 [doi]
PST - ppublish
SO  - Pan Afr Med J. 2011;9:36. doi: 10.4314/pamj.v9i1.71214. Epub 2011 Aug 1.


PMID- 22352207
OWN - NLM
STAT- MEDLINE
DCOM- 20120320
LR  - 20120222
IS  - 0370-8179 (Print)
IS  - 0370-8179 (Linking)
VI  - 139 Suppl 1
DP  - 2011 Dec
TI  - Most common diagnoses requiring physical restriction of psychiatric patients:
      humanity at the test.
PG  - 65-71
AB  - INTRODUCTION: Attitude about physical restriction has been changing through
      history. It has always been multidimensional approach, including ethic, medical
      and judicial aspect. OBJECTIVE: The main aim was establishing distribution of
      physical restrictions of patients for the following years: 2006/07, 2007/08,
      2008/09, 2009/10 and 2010/11. METHODS: The research included patients that were
      hospitalized in the Special Hospital for Psychiatric Disorders "Dr. Laza
      Lazarevic" in Belgrade from June 1, 2006 to June 1, 2011. Retrospective review of
      illness history of hospitalized female patients was done (350 in total) and
      records were formed containing data on physically restrained patients. RESULTS:
      The largest number of referral diagnoses belonged to groups F20, F23 and F29; it 
      was established that the number of physical restrictions was associated with
      referral diagnoses on the level of highly statistically significant difference (p
      < 0.001). The average number of restrainees per hospitalized patient which was
      growing in the studied period, which was also shown by the trend line (y = 0.5x +
      1.06; R2 = 0.7242). CONCLUSION: Physical restrictions of psychiatric patients
      must backed up by benevolence, and it is not by any means the doctor's
      arbitrariness, which is strongly criticized and represents breach of ethical
      norms, human rights and the rights of the patient as guaranteed by law. This
      topic, which, indeed, refers to modern psychiatry, deserves more attention by
      public discussions, as well as by legislative regulations.
FAU - Nenadovic, Milutin
AU  - Nenadovic M
AD  - Special Hospital for Mental Disorders "Dr. Laza Lazarevic", Belgrade, Serbia.
FAU - Katanic, Marija
AU  - Katanic M
FAU - Tocilovac-Nina, Mirjana
AU  - Tocilovac-Nina M
FAU - Kostic, Vesna
AU  - Kostic V
FAU - Peruncic, Mira
AU  - Peruncic M
FAU - Simonovic, Perisa
AU  - Simonovic P
FAU - Radomirovic, Miroslav
AU  - Radomirovic M
FAU - Vicentic, Sreten
AU  - Vicentic S
LA  - eng
PT  - Journal Article
PL  - Serbia
TA  - Srp Arh Celok Lek
JT  - Srpski arhiv za celokupno lekarstvo
JID - 0027440
SB  - IM
MH  - Adult
MH  - Female
MH  - Hospitals, Psychiatric/statistics & numerical data
MH  - Humans
MH  - Mental Disorders/*therapy
MH  - Restraint, Physical/*statistics & numerical data
EDAT- 2012/02/23 06:00
MHDA- 2012/03/21 06:00
CRDT- 2012/02/23 06:00
PHST- 2012/02/23 06:00 [entrez]
PHST- 2012/02/23 06:00 [pubmed]
PHST- 2012/03/21 06:00 [medline]
PST - ppublish
SO  - Srp Arh Celok Lek. 2011 Dec;139 Suppl 1:65-71.


PMID- 22352198
OWN - NLM
STAT- MEDLINE
DCOM- 20120320
LR  - 20131121
IS  - 0370-8179 (Print)
IS  - 0370-8179 (Linking)
VI  - 139 Suppl 1
DP  - 2011 Dec
TI  - Reasons and conditions for involuntary hospitalization with special emphasis on
      detention without consent of mentally disordered person who voluntarily started
      hospital treatment.
PG  - 21-5
AB  - The nature of some mental illness is such that persons affected by their conduct 
      endangering life, health and safety, as well as life, health and safety of others
      from their surroundings. These persons, because of their mental condition, are
      often unable to properly assess their own interest. Because of the above it is
      permitted for these persons, under certain circumstances, to be forcibly
      hospitalized against their will. However, the problem of involuntary
      hospitalization of persons with mental disorders remains a controversial and
      complex ethical and legal problem, because it is characterized by a conflict of
      opposing interests and moral values. The main reason is the fact that involuntary
      hospitalization is an act of deprivation of liberty and intervention into the
      personal integrity, which at that the measure is taken against the individual who
      has not committed any crime. In order to provide restricted approach to the
      application of compulsory hospitalization, it is necessary to pass a legislation 
      on the protection of persons with mental disorders that would more closely define
      the undertaken proceedings, reasons and conditions for involuntary detention and 
      involuntary hospitalization in a psychiatric institution, forced detention of
      voluntarily hospitalized persons and penal policy violation of this law. It is
      necessary to initiate the procedure for amending the Law on Contested Procedure, 
      which would reform the procedure for compulsory hospitalization, as an important 
      segment of mentally disordered persons' rights, in order to be in accordance with
      international and European standards within this field.
FAU - Simonovic, Perisa
AU  - Simonovic P
AD  - Institute of Mental Health, Belgrade, Serbia. perisa.simonovic@zdravlje.gov.rs
FAU - Nenadovic, Milutin
AU  - Nenadovic M
FAU - Momcilovic, Dragana
AU  - Momcilovic D
LA  - eng
PT  - Journal Article
PL  - Serbia
TA  - Srp Arh Celok Lek
JT  - Srpski arhiv za celokupno lekarstvo
JID - 0027440
RN  - 8G167061QZ (Ethambutol)
SB  - IM
MH  - *Commitment of Mentally Ill/legislation & jurisprudence
MH  - Ethambutol
MH  - Humans
MH  - Mental Disorders/*therapy
EDAT- 2012/02/23 06:00
MHDA- 2012/03/21 06:00
CRDT- 2012/02/23 06:00
PHST- 2012/02/23 06:00 [entrez]
PHST- 2012/02/23 06:00 [pubmed]
PHST- 2012/03/21 06:00 [medline]
PST - ppublish
SO  - Srp Arh Celok Lek. 2011 Dec;139 Suppl 1:21-5.


PMID- 22346044
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1998-3735 (Electronic)
IS  - 0973-1075 (Linking)
VI  - 17
IP  - 3
DP  - 2011 Sep
TI  - Attitudes Toward Euthanasia Among Doctors in a Tertiary Care Hospital in South
      India: A Cross Sectional study.
PG  - 197-201
LID - 10.4103/0973-1075.92336 [doi]
AB  - CONTEXT: Advances in expertise and equipment have enabled the medical profession 
      to exercise more control over the processes of life and death, creating a number 
      of moral and ethical dilemmas. People may live for extended periods with chronic 
      painful or debilitating conditions that may be incurable. AIM: This study
      attempts to study the attitudes of doctors toward euthanasia and the possible
      factors responsible for these attitudes. SETTINGS AND DESIGN: A cross-sectional
      survey of 213 doctors working at a tertiary care hospital was conducted to
      determine their attitudes toward euthanasia. MATERIALS AND METHODS: A
      self-administered questionnaire was used to assess attitudes and personal
      perceptions about euthanasia. STATISTICAL ANALYSIS USED: The Chi square test was 
      used to assess factors influencing attitudes toward euthanasia. RESULTS: A
      majority of the respondents (69.3%) supported the concept of euthanasia. Relief
      from unbearable pain and suffering was the most commonly (80.3%) cited reason for
      being willing to consider the option of euthanasia. Majority of those who were
      against euthanasia (66.2%) felt that the freedom to perform euthanasia could
      easily be misused. Disapproval of euthanasia was associated with religious
      affiliation (P<0.001) and speciality (P<0.001). CONCLUSIONS: A majority of the
      doctors in this study supported euthanasia for the relief of unbearable pain and 
      suffering. Religion and speciality appear to be significant in determining
      attitudes toward euthanasia.
FAU - Kamath, Sneha
AU  - Kamath S
AD  - Department of Community Medicine, Kasturba Medical College, Manipal University,
      Manipal, India.
FAU - Bhate, Priya
AU  - Bhate P
FAU - Mathew, Ginu
AU  - Mathew G
FAU - Sashidharan, Srijith
AU  - Sashidharan S
FAU - Daniel, Anjali B
AU  - Daniel AB
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Indian J Palliat Care
JT  - Indian journal of palliative care
JID - 101261221
PMC - PMC3276816
OTO - NOTNLM
OT  - Attitudes
OT  - Doctors
OT  - Euthanasia
EDAT- 2012/02/22 06:00
MHDA- 2012/02/22 06:01
CRDT- 2012/02/21 06:00
PHST- 2012/02/21 06:00 [entrez]
PHST- 2012/02/22 06:00 [pubmed]
PHST- 2012/02/22 06:01 [medline]
AID - 10.4103/0973-1075.92336 [doi]
AID - IJPC-17-197 [pii]
PST - ppublish
SO  - Indian J Palliat Care. 2011 Sep;17(3):197-201. doi: 10.4103/0973-1075.92336.


PMID- 22345839
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130704
LR  - 20211021
IS  - 0975-1564 (Electronic)
IS  - 0253-7176 (Linking)
VI  - 33
IP  - 2
DP  - 2011 Jul
TI  - Dilemmas in private psychiatric practice.
PG  - 149-52
LID - 10.4103/0253-7176.92066 [doi]
AB  - BACKGROUND: A practicing psychiatrist faces dilemmas on a number of occasions, in
      deciding the best course of action he/she needs to undertake while treating a
      patient. At times, this choice may not be in accordance with the ethical and
      moral principles and may in fact appear to violate patient's autonomy and rights.
      AIM: To study the nature of psychiatric practice by the practicing psychiatrist
      in the areas of admission, discharge, consent, physical restraint,
      electroconvulsive therapy (ECT), certification, treatment, suicide and
      psychotherapy. SETTINGS AND DESIGN: Cross-sectional observational study.
      MATERIALS AND METHODS: Forty-eight psychiatrists gave consent to participate in
      the study. A special proforma was prepared, which addresses the common dilemmas
      in the clinical psychiatric practice. All the psychiatrists were given specially 
      designed profoma and were requested to fill the proforma with appropriate
      answers. Statistical analysis was done using SPSS software. RESULTS: There were
      42 male and 6 female psychiatrists. The age of the psychiatrists ranged from 28
      to 65 years with a mean of 43.08 years. The mean duration of practice of these
      psychiatrists was 14.81+/-11.07 years. Question and answers related to admission,
      discharge, consent, physical restraint, ECT, certification, treatment, suicide
      and psychotherapy are discussed. CONCLUSIONS: The present standard and practice
      especially in private psychiatric set-up does not confirm to the rules,
      recommendations, and regulations suggested by Mental Health Act 1987, Mental
      Health Authorities and various guidelines of practice. Indian Psychiatric Society
      and other professional bodies need to take steps to prepare guidelines for a good
      psychiatric practice.
FAU - Patil, Nanasaheb M
AU  - Patil NM
AD  - Department of Psychiatry, KLE University's Jawaharlal Nehru Medical College,
      Belgaum, Karnataka, India.
FAU - Nayak, Raghavendra B
AU  - Nayak RB
FAU - Bhogale, Govind S
AU  - Bhogale GS
FAU - Chate, Sameeran S
AU  - Chate SS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Indian J Psychol Med
JT  - Indian journal of psychological medicine
JID - 7910727
PMC - PMC3271489
OTO - NOTNLM
OT  - Ethics
OT  - dilemmas in psychiatry
OT  - mental health act
OT  - private psychiatry
EDAT- 2012/02/22 06:00
MHDA- 2012/02/22 06:01
CRDT- 2012/02/21 06:00
PHST- 2012/02/21 06:00 [entrez]
PHST- 2012/02/22 06:00 [pubmed]
PHST- 2012/02/22 06:01 [medline]
AID - 10.4103/0253-7176.92066 [doi]
AID - IJPsyM-33-149 [pii]
PST - ppublish
SO  - Indian J Psychol Med. 2011 Jul;33(2):149-52. doi: 10.4103/0253-7176.92066.


PMID- 22340314
OWN - NLM
STAT- MEDLINE
DCOM- 20120613
LR  - 20161125
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Linking)
VI  - 124
IP  - 23
DP  - 2011 Dec
TI  - New variables for measuring joint space width to evaluate knee osteoarthritis.
PG  - 3886-90
AB  - BACKGROUND: Assessing the radiographic features of knee osteoarthritis (OA),
      especially joint space narrowing, is important for evaluating disease
      progression. The purpose of this study was to quantitatively analyze joint space 
      narrowing by measuring 2 new variables: the average joint space width (aJSW) and 
      the articulate angle (AA) on X-ray films, and to evaluate the relationship
      between the 2 variables, knee function and OA symptoms. METHODS: Using the
      web-based radiology viewer (Cedara I-Reach 4.1.1), we measured the 2 variables in
      50 knees of 41 patients with knee OA participating in the Shanghai OA Study. We
      also evaluated the Kellgren-Lawrence (K-L) grade, the Western Ontario and
      McMaster Universities OA Index (WOMAC), and additional questionnaire in OA knees.
      The study was approved by the ethics committee of Shanghai Ninth People's
      Hospital (No. 2009 - 28). RESULTS: The aJSW correlated with the K-L grade (r =
      -0.57, P < 0.001), kneeling (r = -0.29, P = 0.04), sitting cross-legged on the
      floor (r = -0.31, P = 0.03), WOMAC pain (r = -0.31, P = 0.03), WOMAC disability
      (r = -0.35, P = 0.01), pain while squatting (r = -0.37, P = 0.01), and defecating
      in a squatting position (r = -0.39, P = 0.01). The AA correlated with defecating 
      in a squatting position (r = 0.29, P = 0.05), WOMAC disability (r = 0.30, P =
      0.04) and K-L grade (r = 0.44, P = 0.003). The K-L grade also correlated with
      pain while squatting (r = -0.40, P = 0.005) and defecating in a squatting
      position (r = -0.34, P = 0.02), WOMAC pain (r = 0.30, P = 0.04), and WOMAC
      disability (r = 0.30, P = 0.04). CONCLUSIONS: The aJSW closely correlated with
      knee OA symptoms and function scores, and was more sensitive to knee OA related
      disabilities than K-L grade and the AA. The aJSW could be used as a new variable 
      for knee OA evaluation.
FAU - An, Bing-Chen
AU  - An BC
AD  - Department of Orthopaedics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong 
      University School of Medicine, Shanghai 200011, China.
FAU - Fang, Kai
AU  - Fang K
FAU - Wang, You
AU  - Wang Y
FAU - Zeng, Yi-Ming
AU  - Zeng YM
FAU - Dai, Ke-Rong
AU  - Dai KR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - Knee Joint/*diagnostic imaging/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Osteoarthritis, Knee/*diagnostic imaging/*physiopathology
MH  - Pain Measurement
MH  - Radiography
EDAT- 2012/02/22 06:00
MHDA- 2012/06/14 06:00
CRDT- 2012/02/21 06:00
PHST- 2012/02/21 06:00 [entrez]
PHST- 2012/02/22 06:00 [pubmed]
PHST- 2012/06/14 06:00 [medline]
PST - ppublish
SO  - Chin Med J (Engl). 2011 Dec;124(23):3886-90.


PMID- 22340001
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140607
LR  - 20120220
IS  - 0255-7053 (Print)
IS  - 0255-7053 (Linking)
VI  - 41
IP  - 5
DP  - 2011 Sep
TI  - [Review of biographies of doctors in Chinese history].
PG  - 259-64
AB  - After reviewing the biographies of doctors recorded in official history of China 
      and books mentioned the biographies, it was seen that biographies of doctors in
      Chinese history are mainly composed of a resume of their life and medical
      achievements. Although a variety of other aspects, such as social, family and
      education background, personality, hobby, speciality, travel experience, medical 
      ethics, comments and achievements outside medicine, which could make those
      figures more vivid, none of these has been described in detail. Biographies about
      doctors of Traditional Chinese Medicine (TCM) should be both scientific and
      popular, and of literary merit on the basis of validity. Biographers should know 
      both doctors' medical achievements and the background of the era, combine the
      internal history and external history and find the relationship between them to
      make reasonable explanations.
FAU - Zhu, Jian-Ping
AU  - Zhu JP
AD  - China Institute for History of Medicine and Medical Literature, China Academy of 
      Chinese Medical Sciences, Beijing, 100700, China.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Shi Za Zhi
JT  - Zhonghua yi shi za zhi (Beijing, China : 1980)
JID - 8303081
EDAT- 2012/02/22 06:00
MHDA- 2012/02/22 06:01
CRDT- 2012/02/21 06:00
PHST- 2012/02/21 06:00 [entrez]
PHST- 2012/02/22 06:00 [pubmed]
PHST- 2012/02/22 06:01 [medline]
PST - ppublish
SO  - Zhonghua Yi Shi Za Zhi. 2011 Sep;41(5):259-64.


PMID- 22338723
OWN - NLM
STAT- MEDLINE
DCOM- 20120322
LR  - 20190518
IS  - 0261-1929 (Print)
IS  - 0261-1929 (Linking)
VI  - 39
IP  - 6
DP  - 2011 Dec
TI  - Eating nanomaterials: cruelty-free and safe? the EFSA guidance on risk assessment
      of nanomaterials in food and feed.
PG  - 567-75
AB  - Nanomaterials are increasingly being added to food handling and packaging
      materials, or directly, to human food and animal feed. To ensure the safety of
      such engineered nanomaterials (ENMs), in May 2011, the European Food Safety
      Authority (EFSA) published a guidance document on Risk assessment of the
      application of nanoscience and nanotechnologies in the food and feed chain. It
      states that risk assessment should be performed by following a step-wise
      procedure. Whenever human or animal exposure to nanomaterials is expected, the
      general hazard characterisation scheme requests information from in vitro
      genotoxicity, toxicokinetic and repeated dose 90-day oral toxicity studies in
      rodents. Numerous prevailing uncertainties with regard to nanomaterial
      characterisation and their hazard and risk assessment are addressed in the
      guidance document. This article discusses the impact of these knowledge gaps on
      meeting the goal of ensuring human safety. The EFSA's guidance on the risk
      assessment of ENMs in food and animal feed is taken as an example for discussion,
      from the point of view of animal welfare, on what level of uncertainty should be 
      considered acceptable for human safety assessment of products with non-medical
      applications, and whether animal testing should be considered ethically
      acceptable for such products.
FAU - Sauer, Ursula G
AU  - Sauer UG
AD  - Scientific Consultancy, Animal Welfare, Neubiberg, Germany.
      ursua.sauer@sauerug.de
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Altern Lab Anim
JT  - Alternatives to laboratory animals : ATLA
JID - 8110074
SB  - IM
MH  - Advisory Committees/*organization & administration
MH  - Animal Experimentation/ethics
MH  - Animal Feed/*analysis
MH  - Animal Welfare
MH  - Animals
MH  - Consumer Product Safety
MH  - *European Union
MH  - *Food Analysis
MH  - Humans
MH  - Nanostructures/*adverse effects
MH  - Risk Assessment
EDAT- 2012/02/22 06:00
MHDA- 2012/03/23 06:00
CRDT- 2012/02/21 06:00
PHST- 2012/02/21 06:00 [entrez]
PHST- 2012/02/22 06:00 [pubmed]
PHST- 2012/03/23 06:00 [medline]
AID - 10.1177/026119291103900611 [doi]
PST - ppublish
SO  - Altern Lab Anim. 2011 Dec;39(6):567-75. doi: 10.1177/026119291103900611.


PMID- 22338290
OWN - NLM
STAT- MEDLINE
DCOM- 20120315
LR  - 20191112
IS  - 0745-5194 (Print)
IS  - 0745-5194 (Linking)
VI  - 25
IP  - 4
DP  - 2011 Dec
TI  - Personhood diagnostics: personal attributes and clinical explanations of pain.
PG  - 457-78
AB  - This article examines an explanation circulating within a U.S. multidisciplinary 
      pediatric pain clinic that links the neurobiology of functional pain disorders to
      desirable personal attributes such as smartness and creativity. Drawing on
      ethnographic observations and the analysis of video-recorded clinical
      interactions and focusing on two cases, I introduce the term personhood
      diagnostics to explore how the explanatory framework worked not only to pinpoint 
      a pathophysiological mechanism for pain to legitimize it as "real" but also to
      cast patients as virtuous persons. In doing so, it laid the groundwork for an
      ethic of clinical care that privileged the patient's responsibility for
      treatment. Within this narrative logic, diagnostic explanations reveal not only
      causal pathways but also predictive claims about recovery. By considering what is
      at stake when personal attributes are marshaled within a neurobiological
      diagnostic register that also lays out the patient's role in healing, this
      article complicates psychosomatic accounts of pain.
FAU - Buchbinder, Mara
AU  - Buchbinder M
AD  - Department of Social Medicine, University of North Carolina at Chapel Hill, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Med Anthropol Q
JT  - Medical anthropology quarterly
JID - 8405037
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Chronic Pain/*diagnosis/*psychology
MH  - Female
MH  - Humans
MH  - Male
MH  - Neurobiology
MH  - *Personality
MH  - Physician-Patient Relations
MH  - Psychophysiologic Disorders/*diagnosis/*psychology
MH  - Social Behavior
MH  - Video Recording
EDAT- 2012/02/18 06:00
MHDA- 2012/03/16 06:00
CRDT- 2012/02/18 06:00
PHST- 2012/02/18 06:00 [entrez]
PHST- 2012/02/18 06:00 [pubmed]
PHST- 2012/03/16 06:00 [medline]
AID - 10.1111/j.1548-1387.2011.01180.x [doi]
PST - ppublish
SO  - Med Anthropol Q. 2011 Dec;25(4):457-78. doi: 10.1111/j.1548-1387.2011.01180.x.


PMID- 22336647
OWN - NLM
STAT- MEDLINE
DCOM- 20120611
LR  - 20220317
IS  - 1213-8118 (Print)
IS  - 1213-8118 (Linking)
VI  - 155
IP  - 4
DP  - 2011 Dec
TI  - Influence of age and gender on the pharmacodynamic parameters of rocuronium
      during total intravenous anesthesia.
PG  - 347-53
LID - 10.55.07/bp.2011.050 [doi]
AB  - AIMS: To compare the pharmacodynamics of 0.6 mg kg(-1) rocuronium in young and
      older patients of both genders during total intravenous anesthesia. METHODS:
      Following local ethics committee approval and informed consent, patients
      scheduled for surgery under total intravenous anesthesia (propofol/sufentanil)
      were divided into 4 study groups: 37 males aged 20-40, 40 males aged 60-75 yrs,
      43 females aged 20-40 and 38 females aged 60-75 yrs. Neuromuscular block
      following rocuronium (0.6 mg kg(-1)) was monitored: train-of-four [TOF]
      stimulation of the ulnar nerve at 15-s intervals, EMG of the adductor pollicis
      muscle. The onset time (from application of rocuronium to maximum depression of
      T(1)), clinical duration (from application to 25% recovery of T(1)), and time to 
      full spontaneous recovery (from application to TOF-ratio >/= 0.9) were determined
      for each patient. The Kruskal-Wallis test was used to compare differences between
      groups; P<0.05 was considered statistically significant. RESULTS: The onset time 
      (median [interquartile range]) in the respective groups was 90 [80-110](BCD), 135
      [116-165](AC), 75 [60-90](ABD), and 120 [90-146](AC) seconds. The clinical
      duration was 30 [25-42](BCD), 58 [53-67](AD), 50 [40-65](AD), and 85 [70-90](ABC)
      min. Interval to full spontaneous recovery was 59 [51-67](BCD), 102 [75-106](A), 
      76 [66-91](AD), and 128 [94-137](AC) min. ((A)P<0.05 vs. young males, (B)P<0.05
      vs. elderly males, (C)P<0.05 vs. young females, (D)P<0.05 vs. elderly females).
      CONCLUSION: Females and older patients were more sensitive to rocuronium.
FAU - Adamus, Milan
AU  - Adamus M
AD  - Department of Anesthesiology and Intensive Care Medicine, University Hospital
      Olomouc, Palacky University Olomouc, Czech Republic. milan.adamus@seznam.cz
FAU - Hrabalek, Lumir
AU  - Hrabalek L
FAU - Wanek, Tomas
AU  - Wanek T
FAU - Gabrhelik, Tomas
AU  - Gabrhelik T
FAU - Zapletalova, Jana
AU  - Zapletalova J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Czech Republic
TA  - Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
JT  - Biomedical papers of the Medical Faculty of the University Palacky, Olomouc,
      Czechoslovakia
JID - 101140142
RN  - 0 (Androstanols)
RN  - 0 (Neuromuscular Nondepolarizing Agents)
RN  - WRE554RFEZ (Rocuronium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aging/metabolism
MH  - Androstanols/administration & dosage/*pharmacokinetics
MH  - *Anesthesia, Intravenous
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Neuromuscular Blockade
MH  - Neuromuscular Nondepolarizing Agents/administration & dosage/*pharmacokinetics
MH  - Rocuronium
MH  - Sex Characteristics
MH  - Young Adult
EDAT- 2012/02/18 06:00
MHDA- 2012/06/12 06:00
CRDT- 2012/02/17 06:00
PHST- 2012/02/17 06:00 [entrez]
PHST- 2012/02/18 06:00 [pubmed]
PHST- 2012/06/12 06:00 [medline]
AID - 10.55.07/bp.2011.050 [doi]
PST - ppublish
SO  - Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2011 Dec;155(4):347-53. doi:
      10.55.07/bp.2011.050.


PMID- 22333199
OWN - NLM
STAT- MEDLINE
DCOM- 20121220
LR  - 20181201
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 91
IP  - 47
DP  - 2011 Dec 20
TI  - [Propofol target controlled infusion plus a low concentration of sevoflurane
      inhalation induction anesthesia for the removal of foreign body from
      tracheobronchus in children].
PG  - 3333-6
AB  - OBJECTIVE: To explore the effects of propofol target controlled infusion (TCI)
      plus a low concentration of sevoflurane inhalation induction for the removal of
      tracheobronchial foreign body in children. METHODS: After the approval of the
      hospital ethics committee, a total of 90 patients, aged 9 - 36 months old and
      weighted 8 - 17 kg, were randomly divided into 3 groups: group A, group B and
      group C. Propofol TCI plus a low concentration of sevoflurane inhalation
      induction was administered in group A while ketamine or fentanyl plus propofol
      TCI in group B or C respectively. Effects of anesthesia, complications and
      recovery durations were observed. RESULTS: The incidence of severe breathholding 
      and bucking during inserting bronchoscope was 1 case in group A, 7 in group B and
      5 in group C. There were significant differences between groups A and B (P <
      0.05). The minimal intra-operative SpO2 in group B or group C was lower than that
      in group A (P < 0.01). The cases for intra-operative SpO2 < 95% in group B or
      group C were more than that in group A (P < 0.01). And the maximal target
      concentration of propofol was significantly higher than that in group A (P <
      0.01). Ten cases in group B had laryngeal stridor and dyspnea during inspirations
      post-operatively and occurred more frequently than those in group A or C (P <
      0.01). As compared with group A and C, post-operative staying lengths and
      recovery durations were significantly longer in those in group B (P < 0.01).
      CONCLUSION: Propofol TCI plus a low concentration of sevoflurane inhalation
      induction is both safe and practical for the controlled removal of
      tracheobronchial foreign body in children.
FAU - Zhang, Xu-tong
AU  - Zhang XT
AD  - Department of Anesthesiology, Second Affiliated Hospital, Wenzhou Medical
      College, Wenzhou 325027, China.
FAU - Qi, Dan-si
AU  - Qi DS
FAU - Liu, Hua-cheng
AU  - Liu HC
FAU - Su, Er-zhan
AU  - Su EZ
FAU - Li, Jun
AU  - Li J
LA  - chi
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 0 (Methyl Ethers)
RN  - 38LVP0K73A (Sevoflurane)
RN  - YI7VU623SF (Propofol)
SB  - IM
MH  - Anesthesia, Inhalation/*methods
MH  - Child, Preschool
MH  - Female
MH  - Foreign Bodies/*surgery
MH  - Humans
MH  - Infant
MH  - Male
MH  - *Methyl Ethers/administration & dosage
MH  - *Propofol/administration & dosage
MH  - Sevoflurane
MH  - *Trachea
EDAT- 2012/02/16 06:00
MHDA- 2012/12/21 06:00
CRDT- 2012/02/16 06:00
PHST- 2012/02/16 06:00 [entrez]
PHST- 2012/02/16 06:00 [pubmed]
PHST- 2012/12/21 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2011 Dec 20;91(47):3333-6.


PMID- 22332983
OWN - NLM
STAT- MEDLINE
DCOM- 20120723
LR  - 20161125
IS  - 1132-1989 (Print)
IS  - 1132-1989 (Linking)
VI  - 22
IP  - 76
DP  - 2011 Sep-Dec
TI  - [Ethical issues in older admitted patients. Experience in the United Kingdom].
PG  - 517-33
AB  - The United Kingdom is a rapidly aging society. More than half of the hospital
      beds are occupied by older people. They are considering increasingly themselves
      as able to flourish, enjoying a fulfilling live and with the same rights and
      dignity than the rest of the population. Keeping independence is one of their
      main objectives. However, this society realized that the Health Service were
      outdated and not suited to the correct needs of the elderly. A new organization
      of the National Health Service, the National Service Framework was developed in
      2001 which led to a health and social care more appropriate. New ethical
      principles as respect to the person, non-discrimination by age and Person Centred
      Care were focused in this new organization. This means providing the
      comprehensive geriatric assessment, rationalization of care with the union of
      social and health services and the pursuit of high levels of quality of care for 
      the elderly. The ethical principles of action with older people also represent
      standards of conduct for doctors, nurses and other healthcare professionals aimed
      at enabling the elderly to make decisions that affect them, to keep their dignity
      and to be given a fair deal and proper care.
FAU - Perez-Jara Carrera, Javier
AU  - Perez-Jara Carrera J
AD  - Unidad de Valoracion Geriatrica, Hospital El Bierzo, Ponferrada, Leon.
      jperezjarac@gmail.com
LA  - spa
PT  - Journal Article
TT  - Cuestiones eticas en los pacientes mayores hospitalizados. Experiencia en el
      Reino Unido.
PL  - Spain
TA  - Cuad Bioet
JT  - Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y
      Etica Medica
JID - 101312976
SB  - IM
MH  - Aged
MH  - *Bioethical Issues
MH  - Health Personnel/ethics
MH  - Health Services for the Aged/*ethics/standards
MH  - *Hospitalization
MH  - Humans
MH  - United Kingdom
EDAT- 2012/02/16 06:00
MHDA- 2012/07/24 06:00
CRDT- 2012/02/16 06:00
PHST- 2011/10/14 00:00 [received]
PHST- 2011/11/12 00:00 [accepted]
PHST- 2012/02/16 06:00 [entrez]
PHST- 2012/02/16 06:00 [pubmed]
PHST- 2012/07/24 06:00 [medline]
PST - ppublish
SO  - Cuad Bioet. 2011 Sep-Dec;22(76):517-33.


PMID- 22332982
OWN - NLM
STAT- MEDLINE
DCOM- 20120723
LR  - 20120215
IS  - 1132-1989 (Print)
IS  - 1132-1989 (Linking)
VI  - 22
IP  - 76
DP  - 2011 Sep-Dec
TI  - [Beyond the informed consent: the relationship consensual].
PG  - 509-16
AB  - The current paradigm of medicine places the principle of self-determination at
      the centre of the system of treatment, as an essential condition for the validity
      of medical action, even from the ethical point of view. But if it is not
      correctly integrated with the former principle, that of doing good, the principle
      of self-determination alone cannot guarantee a fully ethical dimension in medical
      action, among other reasons because it would arrive at a contractual-type way of 
      reasoning, in which the doctor's position would be subordinate to that of the
      patient. Only a situation where both sides are truly equal protagonists in the
      decision-making process, and both truly share the assumption of responsibility,
      can take full account of the centrality of the person in relation to his or her
      treatment. In this way the quality of the relationship, even from the ethical
      standpoint, would be the axis of the treatment paradigm, over and above, for
      instance, informed consent. The demands for euthanasia that could be derived from
      the application of the principle of self-determination need to be forestalled by 
      a renewed discovery of the value of good in its double dimension: the subjective 
      one of the perceived good, and the objective one of the moral good.
FAU - Binetti, Paola
AU  - Binetti P
AD  - Universita Campus BioMedico, Facolta di Medicina, Roma, Italia.
      p.binetti@unicampus.it
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Mas alla del consentimiento informado: La relacion consensual.
PL  - Spain
TA  - Cuad Bioet
JT  - Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y
      Etica Medica
JID - 101312976
SB  - IM
MH  - Humans
MH  - Informed Consent/*ethics
MH  - *Physician-Patient Relations
EDAT- 2012/02/16 06:00
MHDA- 2012/07/24 06:00
CRDT- 2012/02/16 06:00
PHST- 2011/07/04 00:00 [received]
PHST- 2011/08/06 00:00 [accepted]
PHST- 2012/02/16 06:00 [entrez]
PHST- 2012/02/16 06:00 [pubmed]
PHST- 2012/07/24 06:00 [medline]
PST - ppublish
SO  - Cuad Bioet. 2011 Sep-Dec;22(76):509-16.


PMID- 22332504
OWN - NLM
STAT- MEDLINE
DCOM- 20120405
LR  - 20120215
IS  - 0297-2964 (Print)
IS  - 0297-2964 (Linking)
IP  - 107
DP  - 2011 Dec
TI  - [The key of the relational care: the care along the way in the place of
      residence].
PG  - 76-81
AB  - With the advent of the palliative care defined as "active care delivered in a
      global approach of the person reached affected by a serious, evolutionary or
      terminal illness" (SFAP, 1996), the accompaniment found its just place in the
      approach of care. The physical, psychic, moral, social and spiritual dimensions
      are collectively considered in the cultural context of the well-kept person.
      Afterward the concept to take care was developed and found its relevant place in 
      a more and more technical world. The ethics took root in the world medical to
      protect the human being of the possible and sometimes fatal drift of the science.
      The sense of the not only legal but still moral responsibility was reminded as
      well as the importance of the responsibility as essential medical attitude. At
      present the concept of care as kind of relation arouses a renewed interest and of
      generosity which deserves to be deepened to perceive its interest in the world.
FAU - Furstenberg, Cecile
AU  - Furstenberg C
AD  - cecilefurstenberg@yahoo.fr
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - La cle des soins relationnels: la sollicitude en chemin au domicile.
PL  - France
TA  - Rech Soins Infirm
JT  - Recherche en soins infirmiers
JID - 9715370
MH  - *Beneficence
MH  - Humans
MH  - *Nursing Care
MH  - *Palliative Care
MH  - Personhood
MH  - Spirituality
EDAT- 2012/02/16 06:00
MHDA- 2012/04/06 06:00
CRDT- 2012/02/16 06:00
PHST- 2012/02/16 06:00 [entrez]
PHST- 2012/02/16 06:00 [pubmed]
PHST- 2012/04/06 06:00 [medline]
PST - ppublish
SO  - Rech Soins Infirm. 2011 Dec;(107):76-81.


PMID- 22332502
OWN - NLM
STAT- MEDLINE
DCOM- 20120405
LR  - 20120215
IS  - 0297-2964 (Print)
IS  - 0297-2964 (Linking)
IP  - 107
DP  - 2011 Dec
TI  - [Philosophy of care, care and nursing care: a literature review for a research at
      the intersection of philosophy and care].
PG  - 49-59
AB  - Very recently the concept of care has burst on the French philosophical scene.
      What are the contours of this developing "philosophy of care"? How does it place 
      itself in relation to what are today called the ethics of care? And how does it
      take account of nursing care, as a discipline understood in its triple dimension:
      social, pedagogical and epistemological? The research presented in this paper
      examines some of the founding texts of this philosophy of care through the prism 
      of these questions. It is the partial presentation of a reflection developed from
      a literature review that will include two other sections. The second section will
      focus on studying the way in which the ethics of care allow for nursing care and 
      enter into dialogue with the nascent philosophy of care. The third will focus,
      conversely, on the way nurses integrate reflections derived from ethics of care
      and the philosophy of care into the evolution of their own discipline and
      contribute back to the development of a philosophy of care. These three questions
      are in turn part of more extensive research carried out in preparation for a
      philosophy thesis. They are meant as an invitation and a contribution towards
      what we hope will be a successful encounter between philosophy and nursing care.
FAU - Remy-Largeau, Isabelle
AU  - Remy-Largeau I
AD  - IHPST, Universite Paris I. isabelle.remy1@free.fr
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Philosophie du soin, care et soins infirmiers: une revue de litterature pour une 
      recherche au carrefour de la philosophie et du soin.
PL  - France
TA  - Rech Soins Infirm
JT  - Recherche en soins infirmiers
JID - 9715370
MH  - Ethics, Nursing
MH  - Humans
MH  - *Nursing Care
MH  - *Philosophy, Nursing
EDAT- 2012/02/16 06:00
MHDA- 2012/04/06 06:00
CRDT- 2012/02/16 06:00
PHST- 2012/02/16 06:00 [entrez]
PHST- 2012/02/16 06:00 [pubmed]
PHST- 2012/04/06 06:00 [medline]
PST - ppublish
SO  - Rech Soins Infirm. 2011 Dec;(107):49-59.


PMID- 22332501
OWN - NLM
STAT- MEDLINE
DCOM- 20120405
LR  - 20120215
IS  - 0297-2964 (Print)
IS  - 0297-2964 (Linking)
IP  - 107
DP  - 2011 Dec
TI  - [Contribution to an ethics of care--masculinities and gender in the nursing
      profession].
PG  - 38-48
AB  - Today, the nursing profession is almost exclusively associated to women while men
      seem to desert this field in which they were, before the nineteenth century, very
      present. This paper offers a critical look and reflects on the presence of men in
      nursing. The critical perspective of "genderization" as well as the "ethics of
      care" constitutes the cornerstone of the reflection developed in this paper.
      Prejudices against men in the field of nursing are also highlighted, which attest
      that the future of men in this profession is still not assured. From that point
      of view, the "degenderization" of nursing and the valorization of men in the
      history of nursing as well as in the current practice of nursing are presented as
      potential ways forward.
FAU - Roy, Bernard
AU  - Roy B
AD  - Faculte des sciences infirmieres, Universite Laval, Quebec, Canada.
      bernard.roy@fsi.ulaval.ca
FAU - Holmes, Dave
AU  - Holmes D
FAU - Chouinard, Vincent
AU  - Chouinard V
LA  - fre
PT  - English Abstract
PT  - Historical Article
PT  - Journal Article
TT  - Contribution a une ethique de la sollicitude--masculinites et genre dans la
      profession infirmiere.
PL  - France
TA  - Rech Soins Infirm
JT  - Recherche en soins infirmiers
JID - 9715370
MH  - Female
MH  - History of Nursing
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Male
MH  - *Masculinity
MH  - *Men
MH  - *Nursing
MH  - Sex Factors
EDAT- 2012/02/16 06:00
MHDA- 2012/04/06 06:00
CRDT- 2012/02/16 06:00
PHST- 2012/02/16 06:00 [entrez]
PHST- 2012/02/16 06:00 [pubmed]
PHST- 2012/04/06 06:00 [medline]
PST - ppublish
SO  - Rech Soins Infirm. 2011 Dec;(107):38-48.


PMID- 22332439
OWN - NLM
STAT- MEDLINE
DCOM- 20120313
LR  - 20161125
IS  - 1565-1088 (Print)
VI  - 13
IP  - 12
DP  - 2011 Dec
TI  - Physics, biology and the origin of life: the physicians' view.
PG  - 719-24
AB  - Physicians have a great interest in discussions of life and its origin, including
      life's persistence through successive cycles of self-replication under extreme
      climatic and man-made trials and tribulations. We review here the fundamental
      processes that, contrary to human intuition, life may be seen heuristically as an
      ab initio, fundamental process at the interface between the complementary forces 
      of gravitation and quantum mechanics. Analogies can predict applications of
      quantum mechanics to human physiology in addition to that already being applied, 
      in particular to aspects of brain activity and pathology. This potential will
      also extend eventually to, for example, autoimmunity, genetic selection and
      aging. We present these thoughts in perspective against a background of changes
      in some physical fundamentals of science, from the earlier times of the natural
      philosophers of medicine to the technological medical gurus of today. Despite the
      enormous advances in medical science, including integration of technological
      changes that have led to the newer clinical applications of magnetic resonance
      imaging and PET scans and of computerized drug design, there is an intellectual
      vacuum as to how the physics of matter became translated to the biology of life. 
      The essence and future of medicine continue to lie in cautious, systematic and
      ethically bound practice and scientific research based on fundamental physical
      laws accepted as true until proven false.
FAU - Goodman, Geoffrey
AU  - Goodman G
AD  - KfarVradim, Israel.
FAU - Gershwin, M Eric
AU  - Gershwin ME
LA  - eng
PT  - Journal Article
PL  - Israel
TA  - Isr Med Assoc J
JT  - The Israel Medical Association journal : IMAJ
JID - 100930740
SB  - IM
MH  - *Biomedical Research/ethics/trends
MH  - *Biophysics/ethics/trends
MH  - Ethics
MH  - Forecasting
MH  - Humans
MH  - *Life
MH  - *Origin of Life
MH  - Philosophy, Medical
MH  - Physical Phenomena
MH  - Quantum Theory
EDAT- 2012/02/16 06:00
MHDA- 2012/03/14 06:00
CRDT- 2012/02/16 06:00
PHST- 2012/02/16 06:00 [entrez]
PHST- 2012/02/16 06:00 [pubmed]
PHST- 2012/03/14 06:00 [medline]
PST - ppublish
SO  - Isr Med Assoc J. 2011 Dec;13(12):719-24.


PMID- 22332117
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 2156-5554 (Print)
IS  - 2156-5554 (Linking)
VI  - 1
IP  - 4
DP  - 2011 Oct
TI  - They produce the sperm, but whose is it?: The 11 Biology of Spermatozoa Meeting
      September 5-9, 2011-Derbyshire UK.
PG  - 339-340
AB  - Sperm biology pervades numerous research areas from clinical research to
      evolutionary biology and animal conservation. Integrating these fields for a
      better understanding of each is one of the main goals of the Biology of
      Spermatozoa meeting, a conference held biennially outside of Sheffield in the
      United Kingdom. This September, at the 11th meeting, scientists from around the
      globe presented their ongoing research on numerous aspects of reproductive
      biology, from assisted reproduction in humans and animal conservation through
      stem cell research and proteomics to sophisticated evolutionary adaptations of
      ejaculates and female reproductive traits in order to bias paternity toward one
      or the other male in situations of female promiscuity. Throughout the conference,
      ethical controversies with reproductive applications (e.g., sperm banking) found 
      their place just as much as novel clinical technologies (e.g., sperm quality
      assays) or major advances in understanding the mechanisms underlying fundamental 
      processes of postcopulatory sexual selection (e.g., using transgenic animals that
      produce fluorescently labeled sperm). Across a wide range of different taxa, this
      meeting has presented a fascinating synthesis of current research and emerging
      directions in the study of sperm biology.
FAU - Lupold, Stefan
AU  - Lupold S
AD  - Department of Biology; Life Sciences Complex; Syracuse University; Syracuse, NY
      USA.
LA  - eng
PT  - Journal Article
DEP - 20111001
PL  - United States
TA  - Spermatogenesis
JT  - Spermatogenesis
JID - 101543545
PMC - PMC3271645
EDAT- 2012/02/15 06:00
MHDA- 2012/02/15 06:01
CRDT- 2012/02/15 06:00
PHST- 2011/09/30 00:00 [received]
PHST- 2011/10/01 00:00 [accepted]
PHST- 2012/02/15 06:00 [entrez]
PHST- 2012/02/15 06:00 [pubmed]
PHST- 2012/02/15 06:01 [medline]
AID - 10.4161/spmg.1.4.18327 [doi]
AID - 2156-5554-1-4-8 [pii]
PST - ppublish
SO  - Spermatogenesis. 2011 Oct;1(4):339-340. doi: 10.4161/spmg.1.4.18327. Epub 2011
      Oct 1.


PMID- 22331736
OWN - NLM
STAT- MEDLINE
DCOM- 20120816
LR  - 20130206
IS  - 1107-0625 (Print)
IS  - 1107-0625 (Linking)
VI  - 16
IP  - 4
DP  - 2011 Oct-Dec
TI  - Science ethics education part I. Perception and attitude toward scientific fraud 
      among medical researchers.
PG  - 771-7
AB  - PURPOSE: To assess the knowledge of basic principles of responsible conduct of
      research and attitude toward the violations of good scientific practice among
      graduate biomedical students. METHODS: A total of 361 subjects entered the study.
      The study group consisted mainly of graduate students of Medicine (85%), and
      other biomedical sciences (15%). Most participants were on PhD training or on
      postdoctoral training. A specially designed anonymous voluntary multiple-choice
      questionnaire was distributed to them. The questionnaire consisted of 43
      questions divided in 7 parts, each aimed to assess the participants' previous
      knowledge and attitudes toward ethical principles of science and the main types
      of scientific fraud, falsification, fabrication of data, plagiarism, and false
      authorship. RESULTS: Although they considered themselves as insufficiently
      educated on science ethics, almost all participants recognized all types of
      scientific fraud, qualified these issues as highly unethical, and expressed
      strong negative attitude toward them. Despite that, only about half of the
      participants thought that superiors-violators of high ethical standards of
      science deserve severe punishment, and even fewer declared that they would
      whistle blow. These percentages were much greater in cases when the students had 
      personally been plagiarized. CONCLUSION: Our participants recognized all types of
      scientific fraud as violation of ethical standards of science, expressed strong
      negative attitude against fraud, and believed that they would never commit fraud,
      thus indicating their own high moral sense. However, the unwillingness to whistle
      blow and to punish adequately the violators might be characterized as
      opportunistic behavior.
FAU - Vuckovic-Dekic, L
AU  - Vuckovic-Dekic L
AD  - Institute for Oncology and Radiology of Serbia, Belgrade, Serbia.
      ljiljanavd@gmail.com
FAU - Gavrilovic, D
AU  - Gavrilovic D
FAU - Kezic, I
AU  - Kezic I
FAU - Bogdanovic, G
AU  - Bogdanovic G
FAU - Brkic, S
AU  - Brkic S
LA  - eng
PT  - Journal Article
PL  - Cyprus
TA  - J BUON
JT  - Journal of B.U.ON. : official journal of the Balkan Union of Oncology
JID - 100883428
SB  - IM
CIN - J BUON. 2012 Jan-Mar;17(1):196; author reply 196-7. PMID: 22517722
CIN - J BUON. 2012 Oct-Dec;17(4):804; author's reply p. 804. PMID: 23387093
MH  - Adult
MH  - Biomedical Research/*ethics
MH  - Female
MH  - Humans
MH  - Male
MH  - Scientific Misconduct/*ethics
EDAT- 2012/02/15 06:00
MHDA- 2012/08/17 06:00
CRDT- 2012/02/15 06:00
PHST- 2012/02/15 06:00 [entrez]
PHST- 2012/02/15 06:00 [pubmed]
PHST- 2012/08/17 06:00 [medline]
PST - ppublish
SO  - J BUON. 2011 Oct-Dec;16(4):771-7.


PMID- 22330784
OWN - NLM
STAT- MEDLINE
DCOM- 20120529
LR  - 20211021
IS  - 2769-6677 (Electronic)
IS  - 1559-6109 (Linking)
VI  - 50
IP  - 6
DP  - 2011 Nov
TI  - Inclusion of policies on ethical standards in animal experiments in biomedical
      science journals.
PG  - 901-3
AB  - Most published biomedical research involving animal models is evaluated carefully
      to ensure that appropriate ethical standards are met. In the current study, 500
      journals randomly selected from MedLine were assessed for whether they presented 
      animal research. Of the 138 journals that did, the instructions to authors of 85 
      (61.6%) included a requirement for author assurance of adherence to ethical
      standards during experiments involving animals. In comparison to a wider range of
      biologic journals, biomedical science journals were more likely to have some sort
      of ethical policy concerning the reporting and presentation of animal
      experiments.
FAU - Rands, Sean A
AU  - Rands SA
AD  - Centre for Behavioural Biology, School of Veterinary Science, University of
      Bristol, Bristol, UK. sean.rands@bristol.ac.uk
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Assoc Lab Anim Sci
JT  - Journal of the American Association for Laboratory Animal Science : JAALAS
JID - 101269489
SB  - IM
MH  - Animal Experimentation/*ethics/standards
MH  - *Biomedical Research
MH  - *Editorial Policies
MH  - *Ethics
MH  - MEDLINE
MH  - *Serial Publications
PMC - PMC3228928
EDAT- 2012/02/15 06:00
MHDA- 2012/05/30 06:00
CRDT- 2012/02/15 06:00
PHST- 2012/02/15 06:00 [entrez]
PHST- 2012/02/15 06:00 [pubmed]
PHST- 2012/05/30 06:00 [medline]
PST - ppublish
SO  - J Am Assoc Lab Anim Sci. 2011 Nov;50(6):901-3.


PMID- 22329230
OWN - NLM
STAT- MEDLINE
DCOM- 20120306
LR  - 20120214
IS  - 1551-8892 (Print)
IS  - 1551-8892 (Linking)
IP  - 100
DP  - 2011-2012 Winter
TI  - Diversity & social justice in maternity care as an ethical concern.
PG  - 48-50
FAU - Lasser, Jon
AU  - Lasser J
AD  - School Psychology Program, Texas State University, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Midwifery Today Int Midwife
JT  - Midwifery today with international midwife
JID - 100888783
MH  - Cooperative Behavior
MH  - *Cultural Competency
MH  - *Cultural Diversity
MH  - *Ethics, Medical
MH  - *Ethics, Nursing
MH  - Female
MH  - Humans
MH  - Male
MH  - Midwifery/ethics
MH  - Morals
MH  - Pregnancy
MH  - Prenatal Care/*ethics
MH  - *Social Justice
MH  - Social Values
MH  - United States
EDAT- 2012/02/15 06:00
MHDA- 2012/03/07 06:00
CRDT- 2012/02/15 06:00
PHST- 2012/02/15 06:00 [entrez]
PHST- 2012/02/15 06:00 [pubmed]
PHST- 2012/03/07 06:00 [medline]
PST - ppublish
SO  - Midwifery Today Int Midwife. 2011-2012 Winter;(100):48-50.


PMID- 22325105
OWN - NLM
STAT- MEDLINE
DCOM- 20120621
LR  - 20191210
IS  - 1865-9217 (Print)
IS  - 1865-9217 (Linking)
VI  - 106
IP  - 1
DP  - 2012
TI  - [Ethical issues raised by direct-to-consumer personal genome analysis and whole
      body scans: discussion and contextualisation of a report by the Nuffield Council 
      on Bioethics].
PG  - 29-39
LID - 10.1016/j.zefq.2011.09.025 [doi]
AB  - The paradigm of personalised medicine has many different facets, further to the
      application of pharmacogenetics. We examine here (direct-to-consumer) personal
      genome analysis and whole body scans and summarise findings from the Nuffield
      Council's on Bioethics recent report "Medical profiling and online medicine: the 
      ethics of 'personalised healthcare' in a consumer age". We describe the current
      situation in Germany with regard to access to such services, and contextualise
      the Nuffield Council's report with summaries of position statements by German
      professional bodies. We conclude with three points that merit examination further
      to the analyses of the Nuffield Council's report and the German professional
      bodies. These concern the role of indirect evidence in considering restrictive
      policies, the question of whether regulations should require commercial providers
      to contribute to the generation of better evidence, and the option of using data 
      from evaluations in combination with indirect evidence in justifying restrictive 
      policies.
CI  - Copyright (c) 2011. Published by Elsevier GmbH.
FAU - Buyx, Alena M
AU  - Buyx AM
AD  - Nuffield Council on Bioethics, London, Grossbritannien.
      abuyx@nuffieldbioethics.org
FAU - Strech, Daniel
AU  - Strech D
FAU - Schmidt, Harald
AU  - Schmidt H
LA  - ger
PT  - Case Reports
PT  - Journal Article
TT  - Zur Ethik einer Vorsorge durch (direct-to-consumer) individuelle Genanalysen und 
      Ganzkorper-MRTs. Erlauterung und Diskussion der Empfehlungen des Nuffield Council
      on Bioethics.
DEP - 20111005
PL  - Netherlands
TA  - Z Evid Fortbild Qual Gesundhwes
JT  - Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen
JID - 101477604
SB  - IM
MH  - Adult
MH  - Commerce/*ethics
MH  - Cytogenetic Analysis/*ethics
MH  - Direct Service Costs/ethics
MH  - Electronic Health Records
MH  - *Ethics, Medical
MH  - Female
MH  - Genetic Testing/*ethics
MH  - Germany
MH  - Humans
MH  - Internet
MH  - Magnetic Resonance Imaging/*ethics
MH  - Patient Participation
MH  - *Power, Psychological
MH  - Precision Medicine/*ethics
MH  - Preventive Health Services/*ethics
MH  - Private Practice/ethics
MH  - Whole Body Imaging/*ethics
EDAT- 2012/02/14 06:00
MHDA- 2012/06/22 06:00
CRDT- 2012/02/14 06:00
PHST- 2011/07/14 00:00 [received]
PHST- 2011/09/06 00:00 [revised]
PHST- 2011/09/14 00:00 [accepted]
PHST- 2012/02/14 06:00 [entrez]
PHST- 2012/02/14 06:00 [pubmed]
PHST- 2012/06/22 06:00 [medline]
AID - S1865-9217(11)00271-6 [pii]
AID - 10.1016/j.zefq.2011.09.025 [doi]
PST - ppublish
SO  - Z Evid Fortbild Qual Gesundhwes. 2012;106(1):29-39. doi:
      10.1016/j.zefq.2011.09.025. Epub 2011 Oct 5.


PMID- 22324219
OWN - NLM
STAT- MEDLINE
DCOM- 20120307
LR  - 20120213
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 22
IP  - 4
DP  - 2011 Winter
TI  - Clinical ethics consultation's dilemma, and a solution.
PG  - 380-92
AB  - Clinical ethics consultation is on the horns of a dilemma. One horn skewers the
      field for its lack of standards, while the other horn skewers it for proposing
      arbitrary or deeply contested foundations. I articulate the dilemma by discussing
      several critiques of the field and the challenge of formulating standards and
      suggest that the solution lies, at least until a robust consensus emerges, with
      establishing a list of proscriptive standards to guide the field.
FAU - Rasmussen, Lisa M
AU  - Rasmussen LM
AD  - Department of Philosophy at the University of North Carolina, Charlotte, USA.
      lrasmuss@uncc.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
MH  - Bioethics
MH  - *Conflict of Interest
MH  - Consensus
MH  - *Contracts
MH  - Ethicists/*standards
MH  - *Ethics Consultation/standards
MH  - Ethics, Medical
MH  - Humans
MH  - Moral Obligations
EDAT- 2012/02/14 06:00
MHDA- 2012/03/08 06:00
CRDT- 2012/02/14 06:00
PHST- 2012/02/14 06:00 [entrez]
PHST- 2012/02/14 06:00 [pubmed]
PHST- 2012/03/08 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2011 Winter;22(4):380-92.


PMID- 22324218
OWN - NLM
STAT- MEDLINE
DCOM- 20120307
LR  - 20191210
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 22
IP  - 4
DP  - 2011 Winter
TI  - Commentary on Fiester's "Ill-placed democracy: ethics consultations and the moral
      status of voting".
PG  - 373-9
AB  - Autumn Fiester identifies an important element in clinical ethics consultation
      (CEC) that she labels, from the Greek, aporia, "state of perplexity," evidenced
      in CEC as ethical ambiguity. Fiester argues that the inherent difficulties of
      cases so characterized render them inappropriate for voting and more amenable to 
      mediation and the search for consensus. This commentary supports Fiester's
      analysis and adds additional reasons for rejecting voting as a process for
      resolving disputes in CEC including: it distorts the analysis by empowering
      individual voters preferences and biases rather than focusing on the interests
      and wishes of the patient and family; it offers an insufficiently sensitive model
      for resolving the awesome, nuanced, conflicted, and ethically complex issues
      surrounding life and death; it marginalizes minority opinions that may have moral
      validity.
FAU - Dubler, Nancy Neveloff
AU  - Dubler NN
AD  - Montefiore-Einstein Bioethics Center, New York City, NY, USA.
      ndubler@montefiore.org
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
CON - J Clin Ethics. 2011 Winter;22(4):363-72. PMID: 22324217
MH  - *Conflict, Psychological
MH  - *Democracy
MH  - Ethics Consultation/*ethics
MH  - Humans
MH  - Male
MH  - *Moral Obligations
MH  - *Negotiating
MH  - *Politics
MH  - *Social Values
EDAT- 2012/02/14 06:00
MHDA- 2012/03/08 06:00
CRDT- 2012/02/14 06:00
PHST- 2012/02/14 06:00 [entrez]
PHST- 2012/02/14 06:00 [pubmed]
PHST- 2012/03/08 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2011 Winter;22(4):373-9.


PMID- 22324217
OWN - NLM
STAT- MEDLINE
DCOM- 20120307
LR  - 20191210
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 22
IP  - 4
DP  - 2011 Winter
TI  - Ill-placed democracy: ethics consultations and the moral status of voting.
PG  - 363-72
AB  - As groups around the country begin to craft standards for clinical ethics
      consultations, one focus of that work is the proper procedure for conducting
      ethics consults. From a recent empirical look into the workings of ethics consult
      services (ECSs), one worrisome finding is that some ECSs rely on a committee vote
      when making a recommendation. This article examines the practice of voting and
      its moral standing as a procedural strategy for arriving at a clinical ethics
      recommendation. I focus here on the type of clinical ethics conflicts that are
      most likely to lead an ECS to vote, namely, conflicts involving ethical
      uncertainty--or, in the Greek, aporia. I argue that in cases of aporia, voting on
      an ethics conflict is not a morally justifiable procedure. Then on the same
      grounds that I use to show that voting is ethically problematic, I raise broader 
      concerns about the common practice of making recommendations by other procedures.
      In contrast to the standard approach of adjudicating between moral claims, I
      argue that ECSs can best resolve aporetic conflict through the process of
      clinical ethics mediation.
FAU - Fiester, Autumn M
AU  - Fiester AM
AD  - University of Pennsylvania Department of Medical Ethics and Health Policy,
      Philadelphia, USA. fiester@mail.med.upenn.edu
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
CIN - J Clin Ethics. 2011 Winter;22(4):373-9. PMID: 22324218
MH  - Adult
MH  - Brain Death
MH  - *Conflict, Psychological
MH  - Cryopreservation/ethics
MH  - *Democracy
MH  - Ethical Analysis
MH  - Ethical Theory
MH  - Ethics Consultation/*ethics
MH  - Ethics, Medical
MH  - Humans
MH  - Male
MH  - *Moral Obligations
MH  - *Negotiating
MH  - Patient Advocacy
MH  - *Politics
MH  - *Social Values
MH  - Spermatozoa
EDAT- 2012/02/14 06:00
MHDA- 2012/03/08 06:00
CRDT- 2012/02/14 06:00
PHST- 2012/02/14 06:00 [entrez]
PHST- 2012/02/14 06:00 [pubmed]
PHST- 2012/03/08 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2011 Winter;22(4):363-72.


PMID- 22324216
OWN - NLM
STAT- MEDLINE
DCOM- 20120307
LR  - 20181201
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 22
IP  - 4
DP  - 2011 Winter
TI  - Commentary on "Consensus, clinical decision making, and unsettled cases".
PG  - 354-7; author reply 358-62
AB  - Ethics consultation, while often a process of negotiation between diverse
      opinions, sometimes requires deeper moral inquiry. The form of such inquiry is
      suggested by classical casuistry and its attendant doctrine of probabilism.
FAU - Jonsen, Albert R
AU  - Jonsen AR
AD  - University of Washington, School of Medicine, USA. ARJONSEN@aol.com
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
RN  - Chromosome 18, trisomy 18p
RN  - Chromosome 18, trisomy 18q
SB  - IM
CON - J Clin Ethics. 2011 Winter;22(4):310-27. PMID: 22324212
MH  - Chromosomes, Human, Pair 18
MH  - *Consensus
MH  - Decision Making/*ethics
MH  - *Ethics Consultation
MH  - Female
MH  - Humans
MH  - *Moral Obligations
MH  - *Organizational Policy
MH  - Palliative Care/*ethics
MH  - *Trisomy
EDAT- 2012/02/14 06:00
MHDA- 2012/03/08 06:00
CRDT- 2012/02/14 06:00
PHST- 2012/02/14 06:00 [entrez]
PHST- 2012/02/14 06:00 [pubmed]
PHST- 2012/03/08 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2011 Winter;22(4):354-7; author reply 358-62.


PMID- 22324215
OWN - NLM
STAT- MEDLINE
DCOM- 20120307
LR  - 20181201
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 22
IP  - 4
DP  - 2011 Winter
TI  - "Facilitated consensus," "ethics facilitation," and unsettled cases.
PG  - 345-53; author reply 358-62
AB  - In "Consensus, Clinical Decision Making, and Unsettled Cases:' David M. Adams and
      William J.Winslade' make multiple references to both editions of the American
      Society of Bioethics and Humanities (ASBH) Core Competencies for Healthcare
      Ethics Consultation in their discussion of two assumptions that are supposed to
      be at the heart of the facilitated consensus model's inability to handle
      unsettled cases; that is, that: 1. Consultants "should maintain a kind of moral
      impartiality or neutrality throughout the process," "explicitly condemn[ing]
      anything resembling a substantive 'ethics' recommendation, and 2. "What counts as
      the proper set of allowable options among which the parties are to deliberate
      will itself always be clearly discernible' Herein, I argue that neither of these 
      assumptions is required by ASBH's ethics facilitation approach. I then conclude
      by suggesting that, despite their fundamentally mistaken interpretation of the
      ASBH approach-perhaps even because of it-Adams and Winslade have made two
      important contributions to the ethics consultation literature.
FAU - Aulisio, Mark R
AU  - Aulisio MR
AD  - Center for Biomedical Ethics, MetroHealth, Case Western Reserve University,
      Cleveland, Ohio, USA. mark.aulisio@case.edu
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
RN  - Chromosome 18, trisomy 18p
RN  - Chromosome 18, trisomy 18q
SB  - IM
CON - J Clin Ethics. 2011 Winter;22(4):310-27. PMID: 22324212
MH  - Chromosomes, Human, Pair 18
MH  - *Consensus
MH  - Decision Making/*ethics
MH  - *Ethics Consultation
MH  - Female
MH  - Humans
MH  - *Moral Obligations
MH  - *Organizational Policy
MH  - Palliative Care/*ethics
MH  - *Trisomy
EDAT- 2012/02/14 06:00
MHDA- 2012/03/08 06:00
CRDT- 2012/02/14 06:00
PHST- 2012/02/14 06:00 [entrez]
PHST- 2012/02/14 06:00 [pubmed]
PHST- 2012/03/08 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2011 Winter;22(4):345-53; author reply 358-62.


PMID- 22324214
OWN - NLM
STAT- MEDLINE
DCOM- 20120307
LR  - 20181201
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 22
IP  - 4
DP  - 2011 Winter
TI  - Confronting ambiguity: identifying options for infants with trisomy 18.
PG  - 338-44; author reply 358-62
AB  - Identifying ethically allowable options for infants with trisomy 18 has become
      more challenging as medical standards of practice shift, based on emerging
      scientific data and changing societal perceptions of disability. Lack of a stable
      professional standard of practice ought not prevent ethicists from facilitating a
      consensus; rather, these "unsettled cases" require an individualized, narrative
      approach that allows the values of the family and the particularities of each
      case to provide the necessary additional moral grounding.
FAU - Derrington, Sabrina F
AU  - Derrington SF
AD  - Comfort and Palliative Care Team, Children's Hospital Los Angeles, CA, USA.
      sderrington@chla.usc.edu
FAU - Dworetz, April R
AU  - Dworetz AR
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
RN  - Chromosome 18, trisomy 18p
RN  - Chromosome 18, trisomy 18q
SB  - IM
CON - J Clin Ethics. 2011 Winter;22(4):310-27. PMID: 22324212
MH  - Chromosomes, Human, Pair 18
MH  - *Consensus
MH  - Decision Making/*ethics
MH  - *Ethics Consultation
MH  - Female
MH  - Humans
MH  - *Moral Obligations
MH  - *Organizational Policy
MH  - Palliative Care/*ethics
MH  - *Trisomy
EDAT- 2012/02/14 06:00
MHDA- 2012/03/08 06:00
CRDT- 2012/02/14 06:00
PHST- 2012/02/14 06:00 [entrez]
PHST- 2012/02/14 06:00 [pubmed]
PHST- 2012/03/08 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2011 Winter;22(4):338-44; author reply 358-62.


PMID- 22324213
OWN - NLM
STAT- MEDLINE
DCOM- 20120307
LR  - 20181201
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 22
IP  - 4
DP  - 2011 Winter
TI  - The role of the clinical ethics consultant in "unsettled" cases.
PG  - 328-34; author reply 335-7
AB  - In this article I take up a central question posed by the article jointly
      authored with Bill Winslade in this issue of JCE: What should be the role of
      clinical ethics consultants (CECs) in (what we call) an unsettled case: that is, 
      a situation in which the range of allowable choices, among which the parties to a
      bioethical disagreement must select, cannot be clearly or completely specified? I
      argue here that CECs should, in such cases, guide the parties by presenting their
      own reasoned conclusions about what the scope of allowable choices should be
      taken to include. Since this position challenges the received view that CECs must
      not express their own moral positions or conclusions in their role as ethicists, 
      I try to defend my view of the CEC's role in unsettled cases against several
      objections.
FAU - Adams, David M
AU  - Adams DM
AD  - Department of Philosophy at California State Polytechnic University, Pomona, USA.
      dmadams@csupomona.edu
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
RN  - Chromosome 18, trisomy 18p
RN  - Chromosome 18, trisomy 18q
SB  - IM
CON - J Clin Ethics. 2011 Winter;22(4):310-27. PMID: 22324212
MH  - Chromosomes, Human, Pair 18
MH  - *Consensus
MH  - Decision Making/*ethics
MH  - *Ethics Consultation
MH  - Female
MH  - Humans
MH  - *Moral Obligations
MH  - *Organizational Policy
MH  - Palliative Care/*ethics
MH  - *Trisomy
EDAT- 2012/02/14 06:00
MHDA- 2012/03/08 06:00
CRDT- 2012/02/14 06:00
PHST- 2012/02/14 06:00 [entrez]
PHST- 2012/02/14 06:00 [pubmed]
PHST- 2012/03/08 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2011 Winter;22(4):328-34; author reply 335-7.


PMID- 22324212
OWN - NLM
STAT- MEDLINE
DCOM- 20120307
LR  - 20120213
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 22
IP  - 4
DP  - 2011 Winter
TI  - Consensus, clinical decision making, and unsettled cases.
PG  - 310-27
AB  - The model of clinical ethics consultation (CEC) defended in the ASBH Core
      Competencies report has gained significant traction among scholars and healthcare
      providers. On this model, the aim of CEC is to facilitate deliberative reflection
      and thereby resolve conflicts and clarify value uncertainty by invoking and
      pursuing a process of consensus building. It is central to the model that the
      facilitated consensus falls within a range of allowable options, defined by
      societal values: prevailing legal requirements, widely endorsed organizational
      policies, and professional standards of practice and codes of conduct. Moreover, 
      the model stipulates that ethics consultants must refrain from giving substantive
      recommendations regarding how parties to a moral disagreement in the clinic
      should evaluate their options. We argue that this model of CEC is incomplete,
      because it wrongly assumes that what counts as the proper set of allowable
      options among which the parties are to deliberate will itself always be clearly
      discernible. We illustrate this problem with a recent case on which one of us
      consulted-a neonate born with trisomy 18 (T18). We try to show that law, policy, 
      and standards of practice reveal no clear answer to the question posed by the
      case: namely, whether forgoing gastrostomy tube feedings for a baby with T18 is
      allowable. We suggest there may be other kinds of cases in which it may simply be
      unsettled whether a given choice falls within the set of allowable options within
      which consensus is to be facilitated. What should an ethicist do when confronting
      such unsettled cases? We agree with the facilitation model that an ethicist
      should remain neutral among the allowable options, when it is clear what the
      allowable options are. But, in unsettled cases, the role of a consultant should
      be expanded to include a process of moral inquiry into what the allowable options
      should be. We end by raising the issue of whether this means an ethicist should
      share his or her own conclusions or views about the allowability of a given
      clinical option.
FAU - Adams, David M
AU  - Adams DM
AD  - Department of Philosophy at California State Polytechnic University, Pomona, USA.
      dmadams@csupomona.edu
FAU - Winslade, William J
AU  - Winslade WJ
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
RN  - Chromosome 18, trisomy 18p
RN  - Chromosome 18, trisomy 18q
SB  - IM
CIN - J Clin Ethics. 2011 Winter;22(4):328-34; author reply 335-7. PMID: 22324213
CIN - J Clin Ethics. 2011 Winter;22(4):338-44; author reply 358-62. PMID: 22324214
CIN - J Clin Ethics. 2011 Winter;22(4):345-53; author reply 358-62. PMID: 22324215
CIN - J Clin Ethics. 2011 Winter;22(4):354-7; author reply 358-62. PMID: 22324216
MH  - Choice Behavior/ethics
MH  - Chromosomes, Human, Pair 18
MH  - *Consensus
MH  - Decision Making/*ethics
MH  - *Ethics Consultation/ethics/standards/trends
MH  - Ethics, Institutional
MH  - Ethics, Medical
MH  - Female
MH  - Fluid Therapy/ethics
MH  - Humans
MH  - Infant, Newborn
MH  - Legislation, Medical
MH  - *Moral Obligations
MH  - *Organizational Policy
MH  - Palliative Care/*ethics
MH  - Parenteral Nutrition/ethics
MH  - Prenatal Diagnosis
MH  - *Trisomy/diagnosis
MH  - Uncertainty
EDAT- 2012/02/14 06:00
MHDA- 2012/03/08 06:00
CRDT- 2012/02/14 06:00
PHST- 2012/02/14 06:00 [entrez]
PHST- 2012/02/14 06:00 [pubmed]
PHST- 2012/03/08 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2011 Winter;22(4):310-27.


PMID- 22324211
OWN - NLM
STAT- MEDLINE
DCOM- 20120307
LR  - 20191210
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 22
IP  - 4
DP  - 2011 Winter
TI  - How mediation (and other) approaches may improve ethics consultants' outcomes.
PG  - 299-309
AB  - Articles in this issue of JCE recommend a number of approaches to clinical ethics
      consultation. Given these various approaches, how should ethics consultants
      proceed?
FAU - Howe, Edmund G
AU  - Howe EG
AD  - Medical Ethics, Uniformed Services University of the Health Sciences in Bethesda,
      Maryland, USA.
LA  - eng
PT  - Introductory Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
MH  - *Communication
MH  - Conflict of Interest
MH  - *Consultants
MH  - *Ethics Consultation/ethics/standards/trends
MH  - Ethics, Medical
MH  - Humans
MH  - Motivation
MH  - *Negotiating
MH  - Outcome and Process Assessment, Health Care
MH  - *Patient Advocacy
MH  - *Trust
EDAT- 2012/02/14 06:00
MHDA- 2012/03/08 06:00
CRDT- 2012/02/14 06:00
PHST- 2012/02/14 06:00 [entrez]
PHST- 2012/02/14 06:00 [pubmed]
PHST- 2012/03/08 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2011 Winter;22(4):299-309.


PMID- 22324074
OWN - HMD
STAT- MEDLINE
DCOM- 20121002
LR  - 20191210
IS  - 0952-6951 (Print)
IS  - 0952-6951 (Linking)
VI  - 24
IP  - 4
DP  - 2011
TI  - In praise of counter-conduct.
PG  - 25-41
AB  - Without access to Michel Foucault's courses, it was extremely difficult to
      understand his reorientation from an analysis of the strategies and tactics of
      power immanent in the modern discourse on sexuality (1976) to an analysis of the 
      ancient forms and modalities of relation to oneself by which one constituted
      oneself as a moral subject of sexual conduct (1984). In short, Foucault's passage
      from the political to the ethical dimension of sexuality seemed sudden and
      inexplicable. Moreover, it was clear from his published essays and interviews
      that this displacement of focus had consequences far beyond the specific domain
      of the history of sexuality. "Security, Territory, Population" (Foucault, 2007)
      contains a conceptual hinge, a key concept, that allows us to link together the
      political and ethical axes of Foucault's thought. Indeed, it is Foucault's
      analysis of the notions of conduct and counter-conduct in his lecture of 1 March 
      1978 that seems to me to constitute one of the richest and most brilliant moments
      in the entire course. Is is astonishing, and of profound significance, that the
      autonomous sphere of conduct has been more or less invisible in the history of
      modern (as opposed to ancient) moral and political philosophy. This article
      argues that a new attention should be given to this notion, both in Foucault's
      work and more generally.
FAU - Davidson, Arnold I
AU  - Davidson AI
AD  - University of Chicago, and University of Pisa, Italy.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - England
TA  - Hist Human Sci
JT  - History of the human sciences
JID - 100967737
MH  - *Ethics/history
MH  - History, 20th Century
MH  - History, 21st Century
MH  - *Politics
MH  - *Power, Psychological
MH  - Sexual Behavior/ethnology/history/physiology/psychology
MH  - *Sexuality/ethnology/history/physiology/psychology
MH  - *Social Behavior/history
EDAT- 2012/02/14 06:00
MHDA- 2012/10/04 06:00
CRDT- 2012/02/14 06:00
PHST- 2012/02/14 06:00 [entrez]
PHST- 2012/02/14 06:00 [pubmed]
PHST- 2012/10/04 06:00 [medline]
AID - 10.1177/0952695111411625 [doi]
PST - ppublish
SO  - Hist Human Sci. 2011;24(4):25-41. doi: 10.1177/0952695111411625.


PMID- 22322682
OWN - NLM
STAT- MEDLINE
DCOM- 20120420
LR  - 20121115
IS  - 0035-6484 (Print)
IS  - 0035-6484 (Linking)
VI  - 46
IP  - 5-6
DP  - 2011 Sep-Dec
TI  - [Linguistic evolution and creation in psychotherapy].
PG  - 305-9
LID - 10.1708/1009.10977 [doi]
AB  - AIM: Clarify how linguistic coevolution and creation are crucial in the theory of
      psychotherapeutic technique. METHOD: The paradox of private language, structural 
      coupling and synchronization theory, are introduced in order to highlight how
      multiple components are involved in psychotherapeutic relations. A review and
      discussion of some relevant studies. RESULTS: A therapeutic approach based on
      coevolution, bipersonal fields, implicit communication and procedural knowledge
      can be more effective in modifying different forms of memory. DISCUSSION: This
      evidence based approach represents a scientific advancement in psychotherapy,
      including effectiveness of care, personalisation and ethics.
FAU - Orsucci, Franco F
AU  - Orsucci FF
AD  - Department of Clinical Psychology, University College London, UK.
      f.orsucci@ucl.ac.uk
LA  - ita
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Evoluzione e creazione linguistica in psicoterapia.
PL  - Italy
TA  - Riv Psichiatr
JT  - Rivista di psichiatria
JID - 0425672
SB  - IM
MH  - Biological Evolution
MH  - Communication
MH  - *Creativity
MH  - Evidence-Based Medicine
MH  - Humans
MH  - *Linguistics
MH  - Memory
MH  - Psychotherapy/methods/*trends
EDAT- 2012/02/11 06:00
MHDA- 2012/04/21 06:00
CRDT- 2012/02/11 06:00
PHST- 2012/02/11 06:00 [entrez]
PHST- 2012/02/11 06:00 [pubmed]
PHST- 2012/04/21 06:00 [medline]
AID - 10.1708/1009.10977 [doi]
PST - ppublish
SO  - Riv Psichiatr. 2011 Sep-Dec;46(5-6):305-9. doi: 10.1708/1009.10977.


PMID- 22321931
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20220311
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 91
IP  - 37
DP  - 2011 Oct 11
TI  - [Effect of fascia iliaca compartment block with ropivacaine on early analgesia in
      children with development dislocation of the hip received salter arthroplasty
      treatment].
PG  - 2638-40
AB  - OBJECTIVE: To observe the efficacy and safety of fascia iliaca compartment block 
      (FICB) with 0.2% ropivacaine in the early analgesia of children with development 
      dislocation of the hip (DDH) undergoing Salter arthroplasty. METHODS: Approved by
      the hospital ethics committee, a total of 64 DDH children were divided randomly
      into 2 groups: group F (FICB with ropivacaine 0.2%, 1 ml/kg, max. 30 ml) and
      group C (FICB with 0.9% normal saline 1 ml/kg, max. 30 ml). The intra-operative
      doses of fentanyl, PACU (post-anesthesia care unit), CRIES pain score at 1, 4 and
      24 h postoperatively, patient satisfaction score and side effects were recorded. 
      RESULTS: The intra-operative doses of fentanyl and PACU were lower. Pain scores
      at 1, 4 and 24 h postoperatively were lower. And the patient satisfaction score
      was significantly higher in the FICB group. CONCLUSION: The administration of
      ropivacaine (0.2%) for FICB in the early analgesia of DDH children has the
      advantages of safety, precision, long-lasting and convenience.
FAU - Wang, Geng
AU  - Wang G
AD  - Department of Anesthesia, Jishuitan Hospital, Beijing 100035, China.
FAU - Wang, Xiao-lin
AU  - Wang XL
FAU - Li, Shi-zhong
AU  - Li SZ
LA  - chi
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 0 (Amides)
RN  - 0 (Anesthetics, Local)
RN  - 7IO5LYA57N (Ropivacaine)
SB  - IM
MH  - Amides/*administration & dosage
MH  - Anesthetics, Local/*administration & dosage
MH  - Child
MH  - Child, Preschool
MH  - *Fasciotomy
MH  - Hip Dislocation, Congenital/*surgery
MH  - Humans
MH  - Nerve Block/*methods
MH  - Pain Measurement
MH  - Pain, Postoperative
MH  - Ropivacaine
EDAT- 2012/02/11 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/02/11 06:00
PHST- 2012/02/11 06:00 [entrez]
PHST- 2012/02/11 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2011 Oct 11;91(37):2638-40.


PMID- 22321929
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20131121
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 91
IP  - 37
DP  - 2011 Oct 11
TI  - [Feasibility and safety of acute hypervolemic hemodilution in neurosurgical
      patients].
PG  - 2630-3
AB  - OBJECTIVE: To evaluate the preoperative effects of acute hypervolemic
      hemodilution (AHH) on intracranial pressure, cerebral oxygen supply-demand
      balance and cardiovascular functions of neurosurgical patients. METHODS: Approved
      by hospital ethics committee, a total of 80 ASA grade I/II patients at our
      hospital during 2009, of either gender aged 18-60 yrs, undergoing elective
      craniotomy were recruited. The subjects were randomly divided equally into 2
      groups: group H (hemodilution) and group C (control) (n = 40 each). After
      induction, 6% hydroxyethyl starch solution was infused at the rate of 24
      mlxkg(-1)xh(-1) in group H, while patients in group C received compound
      electrolyte solution at the rate of 6 mlxkg(-1)xh(-1). Central venous pressure
      (CVP), cardiac output index (CI), stroke volume variation (SVV) and cerebral
      spinal fluid pressure (CSFP) were recorded at the following time points: T(Base) 
      (before induction), T(0) (after induction and hemodynamic stabilization), T(30)
      (after infusion for 30 min) and T(60) (after infusion for 60 min). Blood samples 
      from radial artery and jugular bulb were collected and calculated for systemic
      vascular resistance index (SVRI) and cerebral oxygen uptake rate (CERO(2)). The
      dosing frequency of vasoactive drugs was also recorded. RESULTS: CI in group H
      was significantly higher than that in group C (P < 0.01). No significant
      difference was found in both SjvO(2) and CERO(2) between groups and among
      different points of time (P > 0.05). At the end of AHH, CVP and CSFP were (12 +/-
      2.2) mm Hg and (20.0 +/- 2.1) mm Hg respectively. They were significantly higher 
      than that in group C (P < 0.01). CONCLUSION: Preoperative AHH in craniotomy will 
      increase CI and maintain the balance of cerebral oxygen supply. But its clinical 
      application is limited in the patient with high intracranial pressure due to the 
      simultaneous increases in CVP and CSFP.
FAU - Qiao, Hui
AU  - Qiao H
AD  - Department of Anesthesiology, Affiliated Huashan Hospital, Fudan University,
      Shanghai 200040, China.
FAU - Zhang, Jun
AU  - Zhang J
FAU - Liang, Wei-min
AU  - Liang WM
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Brain/metabolism
MH  - Cardiac Output
MH  - Female
MH  - *Hemodilution
MH  - Humans
MH  - Intracranial Pressure
MH  - Male
MH  - Middle Aged
MH  - Neurosurgical Procedures/*methods
MH  - Oxygen/*metabolism
EDAT- 2012/02/11 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/02/11 06:00
PHST- 2012/02/11 06:00 [entrez]
PHST- 2012/02/11 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2011 Oct 11;91(37):2630-3.


PMID- 22321742
OWN - NLM
STAT- MEDLINE
DCOM- 20160423
LR  - 20181201
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 91
IP  - 33
DP  - 2011 Sep 6
TI  - [Development of a new biliary intraluminal irradiation stent and the primary
      results of clinical application].
PG  - 2310-3
AB  - OBJECTIVE: To evaluate the feasibility, safety and efficiency of a new biliary
      intraluminal irradiation stent system loaded with (125)I seeds. METHODS: The
      study was approved by the institutional ethics committee of our hospital, and
      informed consent was obtained from each patient. Patients with malignant biliary 
      obstruction were treated with a new biliary irradiation stent system loaded with 
      (125)I seeds according to a treatment plan system. All of the biliary seeds
      carrying devices combined with the matched biliary stents were placed by the
      procedures of percutaneous transhepatic biliary puncture. After stents
      implantation, all patients were followed-up. RESULTS: The whole biliary stent
      systems loaded with (125)I seeds were successfully placed in 12 patients, no
      (125)I seeds exfoliation during the procedure and no radioactive leakage by
      general emission computed tomography reexamination during the follow-up were
      observed. The obstructive jaundice relived and the systemic conditions improved
      remarkably in all patients. There were no complications related to the stents,
      such as biliary perforation or hemobilia, were observed. And no significant
      change in the blood routine and immune parameters detected before and after
      operation during the follow-up were observed. The median survival period was 7.40
      months (95%CI 6.204 - 8.596) and the mean survival period was 8.03 months (95%CI 
      6.142 - 9.909). CONCLUSION: Development of a new biliary intraluminal irradiation
      stent system loaded with (125)I seeds is technically feasible and safe, treatment
      of this stent system has potential benefits of extending survival, however the
      long-term clinical efficacy needs to be certificated by further follow-up
      observation and control trials.
FAU - Guo, Jin-He
AU  - Guo JH
AD  - Department of Radiology, Zhongda Hospital, Southeast University, Nanjing 210009, 
      China. Email: jinheguo@sina.com.
FAU - Zhu, Guang-Yu
AU  - Zhu GY
FAU - Zhu, Hai-Dong
AU  - Zhu HD
FAU - Li, Guo-Zhao
AU  - Li GZ
FAU - He, Shi-Cheng
AU  - He SC
FAU - Teng, Gao-Jun
AU  - Teng GJ
FAU - Leng, De-Rong
AU  - Leng DR
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
SB  - IM
MH  - *Cholestasis
MH  - Humans
MH  - Jaundice, Obstructive
MH  - Prosthesis Implantation
MH  - Stents
MH  - *Treatment Outcome
EDAT- 2012/02/11 06:00
MHDA- 2016/04/24 06:00
CRDT- 2012/02/11 06:00
PHST- 2012/02/11 06:00 [entrez]
PHST- 2012/02/11 06:00 [pubmed]
PHST- 2016/04/24 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2011 Sep 6;91(33):2310-3.


PMID- 22320876
OWN - NLM
STAT- MEDLINE
DCOM- 20120823
LR  - 20220317
IS  - 1091-3734 (Electronic)
IS  - 1091-3734 (Linking)
VI  - 17
IP  - 1
DP  - 2011 Oct 25
TI  - Ethics: ethics and pain management in hospitalized patients.
PG  - 11
FAU - Bernhofer, Esther
AU  - Bernhofer E
AD  - Cleveland Clinic, Cleveland, OH, USA. bernhoe@ccf.org
LA  - eng
PT  - Journal Article
DEP - 20111025
PL  - United States
TA  - Online J Issues Nurs
JT  - Online journal of issues in nursing
JID - 9806525
SB  - IM
MH  - *Ethics, Nursing
MH  - Hospitalization
MH  - Humans
MH  - Nursing Staff, Hospital/*ethics
MH  - Pain Management/*ethics/*nursing
MH  - Patient Rights/*ethics
MH  - Social Justice/ethics
EDAT- 2012/02/11 06:00
MHDA- 2012/08/24 06:00
CRDT- 2012/02/11 06:00
PHST- 2012/02/11 06:00 [entrez]
PHST- 2012/02/11 06:00 [pubmed]
PHST- 2012/08/24 06:00 [medline]
AID - Vol-17-2012/No1-Jan-2012/Ethics-and-Pain-Management.html [pii]
PST - epublish
SO  - Online J Issues Nurs. 2011 Oct 25;17(1):11.


PMID- 22320008
OWN - NLM
STAT- MEDLINE
DCOM- 20120405
LR  - 20220317
IS  - 1320-159X (Print)
IS  - 1320-159X (Linking)
VI  - 19
IP  - 2
DP  - 2011 Dec
TI  - Psycho-social, ethical and legal arguments for and against the retrospective
      release of information about donors to donor-conceived individuals in Australia.
PG  - 354-76
AB  - In the February 2011 report on its inquiry into the past and present practices of
      donor conception in Australia, the Australian Senate Legal and Constitutional
      Affairs References Committee called for the introduction of legislation to
      regulate donor conception in all jurisdictions that do not have it in place "as a
      matter of priority". It further called for the establishment, "as a matter of
      priority", of a national register of donors to enable donor-conceived individuals
      to access identifying information about their donor. The Senate Committee left
      open the question as to whether the legislation and central register should have 
      retrospective effect. This article focuses upon that question. It shows that
      arguments concerning the privacy, confidentiality and anonymity of some donors
      who may wish to remain anonymous are outweighed by the manifest injustice faced
      by donor-conceived individuals who are denied access to such information, as well
      as their families and donors who wish to exchange this information,
FAU - Allan, Sonia
AU  - Allan S
AD  - Deakin University.
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Law Med
JT  - Journal of law and medicine
JID - 9431853
SB  - IM
MH  - Access to Information/ethics/*legislation & jurisprudence
MH  - Australia
MH  - Confidentiality/*legislation & jurisprudence
MH  - Disclosure/ethics/*legislation & jurisprudence
MH  - Female
MH  - Humans
MH  - Insemination, Artificial, Heterologous
MH  - Male
MH  - Oocyte Donation/*legislation & jurisprudence
MH  - Tissue Donors/*legislation & jurisprudence
EDAT- 2012/02/11 06:00
MHDA- 2012/04/06 06:00
CRDT- 2012/02/11 06:00
PHST- 2012/02/11 06:00 [entrez]
PHST- 2012/02/11 06:00 [pubmed]
PHST- 2012/04/06 06:00 [medline]
PST - ppublish
SO  - J Law Med. 2011 Dec;19(2):354-76.


PMID- 22320006
OWN - NLM
STAT- MEDLINE
DCOM- 20120405
LR  - 20120210
IS  - 1320-159X (Print)
IS  - 1320-159X (Linking)
VI  - 19
IP  - 2
DP  - 2011 Dec
TI  - Sub-Saharan African randomised clinical trials into male circumcision and HIV
      transmission: methodological, ethical and legal concerns.
PG  - 316-34
AB  - In 2007, WHO/UNAIDS recommended male circumcision as an HIV-preventive measure
      based on three sub-Saharan African randomised clinical trials (RCTs) into
      female-to-male sexual transmission. A related RCT investigated male-to-female
      transmission. However, the trials were compromised by inadequate equipoise;
      selection bias; inadequate blinding; problematic randomisation; trials stopped
      early with exaggerated treatment effects; and not investigating non-sexual
      transmission. Several questions remain unanswered. Why were the trials carried
      out in countries where more intact men were HIV-positive than in those where more
      circumcised men were HIV-positive? Why were men sampled from specific ethnic
      subgroups? Why were so many participants lost to follow-up? Why did men in the
      male circumcision groups receive additional counselling on safe sex practices?
      While the absolute reduction in HIV transmission associated with male
      circumcision across the three female-to-male trials was only about 1.3%, relative
      reduction was reported as 60%, but, after correction for lead-time bias, averaged
      49%. In the Kenyan trial, male circumcision appears to have been associated with 
      four new incident infections. In the Ugandan male-to-female trial, there appears 
      to have been a 61% relative increase in HIV infection among female partners of
      HIV-positive circumcised men. Since male circumcision diverts resources from
      known preventive measures and increases risk-taking behaviours, any long-term
      benefit in reducing HIV transmission remains uncertain.
FAU - Boyle, Gregory J
AU  - Boyle GJ
FAU - Hill, George
AU  - Hill G
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Law Med
JT  - Journal of law and medicine
JID - 9431853
SB  - IM
MH  - Africa South of the Sahara
MH  - *Circumcision, Male/ethics
MH  - Developing Countries
MH  - Female
MH  - HIV Infections/*prevention & control/*transmission
MH  - Humans
MH  - Informed Consent
MH  - Male
MH  - Randomized Controlled Trials as Topic/ethics/*methods
EDAT- 2012/02/11 06:00
MHDA- 2012/04/06 06:00
CRDT- 2012/02/11 06:00
PHST- 2012/02/11 06:00 [entrez]
PHST- 2012/02/11 06:00 [pubmed]
PHST- 2012/04/06 06:00 [medline]
PST - ppublish
SO  - J Law Med. 2011 Dec;19(2):316-34.


PMID- 22319999
OWN - NLM
STAT- MEDLINE
DCOM- 20120405
LR  - 20120210
IS  - 1320-159X (Print)
IS  - 1320-159X (Linking)
VI  - 19
IP  - 2
DP  - 2011 Dec
TI  - Living and learning during an ethical crisis in medicine.
PG  - 244-9
AB  - The Cartwright Report was released at a time of massive ethical change in New
      Zealand medicine, the shock waves spreading throughout the region as they caught 
      the surge of interest in patient autonomy and patient rights. The mood was as
      revolutionary for health professionals as the late 1960s and 1970s were for
      society in general, with many established patterns of practice and everyday
      expectations about the nature of clinical care being challenged and disrupted.
      For some of us who witnessed the medico-legal impact of the report in
      Australasia, it revived memories of our time as medical students when the events 
      reported on were being played out. Looking back now on a time of moral crisis in 
      medicine has lessons to teach us which have a timeless quality about them as they
      recall the dim distant days of Semmelweiss and other doctors struggling at a
      political fringe of the profession.
FAU - Gillett, Grant
AU  - Gillett G
AD  - Dunedin Hospital and Otago Bioethics Centre, University of Otago Medical School, 
      New Zealand. grant.gillett@stonebow.otago.ac.nz
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Law Med
JT  - Journal of law and medicine
JID - 9431853
SB  - IM
MH  - Education, Medical/ethics
MH  - *Ethics, Medical
MH  - Faculty, Medical
MH  - Humans
MH  - New Zealand
MH  - Research Report
EDAT- 2012/02/11 06:00
MHDA- 2012/04/06 06:00
CRDT- 2012/02/11 06:00
PHST- 2012/02/11 06:00 [entrez]
PHST- 2012/02/11 06:00 [pubmed]
PHST- 2012/04/06 06:00 [medline]
PST - ppublish
SO  - J Law Med. 2011 Dec;19(2):244-9.


PMID- 22319989
OWN - NLM
STAT- MEDLINE
DCOM- 20120308
LR  - 20190923
IS  - 0035-8665 (Print)
IS  - 0035-8665 (Linking)
VI  - 157
IP  - 4
DP  - 2011 Dec
TI  - Proceedings of the DMS medical ethics symposium.
PG  - 405-10
AB  - This article presents the proceedings of a symposium on medical ethics held at
      the Royal Centre for Defence Medicine in October 2010. The nature of current
      operations continually generates challenging ethical problems, many of which are 
      unique to the military environment. This article is intended to generate a debate
      on these difficult issues and readers are encouraged to contribute to this debate
      by emailing the Editor.
FAU - O'Reilly, D J
AU  - O'Reilly DJ
AD  - Academic Department of Military Surgery and Trauma, Royal Centre for Defence
      Medicine, Vincent Drive, Birmingham. djoreilly@doctors.org.uk
LA  - eng
PT  - Congress
PL  - England
TA  - J R Army Med Corps
JT  - Journal of the Royal Army Medical Corps
JID - 7505627
SB  - IM
MH  - *Ethics, Medical/education
MH  - Humans
MH  - *Military Medicine
MH  - United Kingdom
MH  - Wounds and Injuries/therapy
EDAT- 2012/02/11 06:00
MHDA- 2012/03/09 06:00
CRDT- 2012/02/11 06:00
PHST- 2012/02/11 06:00 [entrez]
PHST- 2012/02/11 06:00 [pubmed]
PHST- 2012/03/09 06:00 [medline]
AID - 10.1136/jramc-157-04-13 [doi]
PST - ppublish
SO  - J R Army Med Corps. 2011 Dec;157(4):405-10. doi: 10.1136/jramc-157-04-13.


PMID- 22319071
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 2150-7740 (Print)
IS  - 2150-7759 (Linking)
VI  - 2
IP  - 2
DP  - 2011 Mar 31
TI  - Response to Open Peer Commentaries on "Neuroethics: A New Way of Doing Ethics"
PG  - W1-W4
FAU - Levy, Neil
AU  - Levy N
AD  - Florey Neuroscience Institutes and Oxford Centre for Neuroethics.
LA  - eng
GR  - 086041/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PL  - United States
TA  - AJOB Neurosci
JT  - AJOB neuroscience
JID - 101518076
PMC - PMC3272471
MID - UKMS40153
EDAT- 2012/02/10 06:00
MHDA- 2012/02/10 06:01
CRDT- 2012/02/10 06:00
PHST- 2012/02/10 06:00 [entrez]
PHST- 2012/02/10 06:00 [pubmed]
PHST- 2012/02/10 06:01 [medline]
AID - 10.1080/21507740.2011.563185 [doi]
PST - ppublish
SO  - AJOB Neurosci. 2011 Mar 31;2(2):W1-W4. doi: 10.1080/21507740.2011.563185.


PMID- 22318976
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 2150-7740 (Print)
IS  - 2150-7759 (Linking)
VI  - 2
IP  - 2
DP  - 2011 Mar 31
TI  - Neuroethics: A New Way of Doing Ethics.
PG  - 3-9
AB  - The aim of this article is to argue, by example, for neuroethics as a new way of 
      doing ethics. Rather than simply giving us a new subject matter-the ethical
      issues arising from neuroscience-to attend to, neuroethics offers us the
      opportunity to refine the tools we use. Ethicists often need to appeal to the
      intuitions provoked by consideration of cases to evaluate the permissibility of
      types of actions; data from the sciences of the mind give us reason to believe
      that some of these intuitions are less reliable than others. I focus on the
      doctrine of double effect to illustrate my case, arguing that experimental
      results suggest that appeal to it might be question-begging. The doctrine of
      double effect is supposed to show that there is a moral difference between
      effects that are brought about intentionally and those that are merely foreseen; 
      I argue that the data suggest that we regard some effects as merely foreseen only
      because we regard bringing them about as permissible. Appeal to the doctrine of
      double effect therefore cannot establish that there are such moral differences.
FAU - Levy, Neil
AU  - Levy N
AD  - Florey Neuroscience Institutes and Oxford Centre for Neuroethics.
LA  - eng
GR  - 086041/Wellcome Trust/United Kingdom
PT  - Journal Article
PL  - United States
TA  - AJOB Neurosci
JT  - AJOB neuroscience
JID - 101518076
PMC - PMC3272467
MID - UKMS40152
EDAT- 2012/02/10 06:00
MHDA- 2012/02/10 06:01
CRDT- 2012/02/10 06:00
PHST- 2012/02/10 06:00 [entrez]
PHST- 2012/02/10 06:00 [pubmed]
PHST- 2012/02/10 06:01 [medline]
AID - 10.1080/21507740.2011.557683 [doi]
PST - ppublish
SO  - AJOB Neurosci. 2011 Mar 31;2(2):3-9. doi: 10.1080/21507740.2011.557683.


PMID- 22318775
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 0264-3758 (Print)
IS  - 0264-3758 (Linking)
VI  - 28
IP  - 4
DP  - 2011 Nov
TI  - Mastery Without Mystery: Why there is no Promethean Sin in Enhancement.
PG  - 355-368
AB  - Several authors have suggested that we cannot fully grapple with the ethics of
      human enhancement unless we address neglected questions about our place in the
      world, questions that verge on theology but can be pursued independently of
      religion. A prominent example is Michael Sandel, who argues that the deepest
      objection to enhancement is that it expresses a Promethean drive to mastery which
      deprives us of openness to the unbidden and leaves us with nothing to affirm
      outside our own wills. Sandel's argument against enhancement has been criticized,
      but his claims about mastery and the unbidden, and their relation to religion,
      have not yet received sufficient attention. I argue that Sandel misunderstands
      the notions of mastery and the unbidden and their significance. Once these
      notions are properly understood, they have surprising implications. It turns out 
      that the value of openness to the unbidden is not just independent of theism, as 
      Sandel claims, but is in fact not even fully compatible with it. But in any case 
      that value cannot support Sandel's objection to enhancement.This is because it is
      not enhancement but certain forms of opposition to enhancement that are most
      likely to express a pernicious drive to mastery.
FAU - Kahane, Guy
AU  - Kahane G
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - 086041/WT_/Wellcome Trust/United Kingdom
GR  - 087208/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PL  - England
TA  - J Appl Philos
JT  - Journal of applied philosophy
JID - 100971946
PMC - PMC3272460
MID - UKMS40144
EDAT- 2012/02/10 06:00
MHDA- 2012/02/10 06:01
CRDT- 2012/02/10 06:00
PHST- 2012/02/10 06:00 [entrez]
PHST- 2012/02/10 06:00 [pubmed]
PHST- 2012/02/10 06:01 [medline]
AID - 10.1111/j.1468-5930.2011.00543.x [doi]
PST - ppublish
SO  - J Appl Philos. 2011 Nov;28(4):355-368. doi: 10.1111/j.1468-5930.2011.00543.x.


PMID- 22315924
OWN - NLM
STAT- MEDLINE
DCOM- 20120227
LR  - 20120209
IS  - 1041-5505 (Print)
IS  - 1041-5505 (Linking)
IP  - 163
DP  - 2011 Nov
TI  - The London low emission zone baseline study.
PG  - 3-79
AB  - On February 4, 2008, the world's largest low emission zone (LEZ) was established.
      At 2644 km2, the zone encompasses most of Greater London. It restricts the entry 
      of the oldest and most polluting diesel vehicles, including heavy-goods vehicles 
      (haulage trucks), buses and coaches, larger vans, and minibuses. It does not
      apply to cars or motorcycles. The LEZ scheme will introduce increasingly
      stringent Euro emissions standards over time. The creation of this zone presented
      a unique opportunity to estimate the effects of a stepwise reduction in vehicle
      emissions on air quality and health. Before undertaking such an investigation,
      robust baseline data were gathered on air quality and the oxidative activity and 
      metal content of particulate matter (PM) from air pollution monitors located in
      Greater London. In addition, methods were developed for using databases of
      electronic primary-care records in order to evaluate the zone's health effects.
      Our study began in 2007, using information about the planned restrictions in an
      agreed-upon LEZ scenario and year-on-year changes in the vehicle fleet in models 
      to predict air pollution concentrations in London for the years 2005, 2008, and
      2010. Based on this detailed emissions and air pollution modeling, the areas in
      London were then identified that were expected to show the greatest changes in
      air pollution concentrations and population exposures after the implementation of
      the LEZ. Using these predictions, the best placement of a pollution monitoring
      network was determined and the feasibility of evaluating the health effects using
      electronic primary-care records was assessed. To measure baseline pollutant
      concentrations before the implementation of the LEZ, a comprehensive monitoring
      network was established close to major roadways and intersections.
      Output-difference plots from statistical modeling for 2010 indicated seven key
      areas likely to experience the greatest change in concentrations of nitrogen
      dioxide (NO2) (at least 3 microg/m3) and of PM with an aerodynamic diameter < or 
      = 10 microm (PM10) (at least 0.75 microg/m3) as a result of the LEZ; these
      suggested that the clearest signals of change were most likely to be measured
      near roadsides. The seven key areas were also likely to be of importance in
      carrying out a study to assess the health outcomes of an air quality intervention
      like the LEZ. Of the seven key areas, two already had monitoring sites with a
      full complement of equipment, four had monitoring sites that required upgrades of
      existing equipment, and one required a completely new installation. With the
      upgrades and new installations in place, fully ratified (verified) pollutant data
      (for PM10, PM with an aerodynamic diameter < or = 2.5 microm [PM2.5], nitrogen
      oxides [NOx], and ozone [O3] at all sites as well as for particle number, black
      smoke [BS], carbon monoxide [CO], and sulfur dioxide [SO2] at selected sites)
      were then collected for analysis. In addition, the seven key monitoring sites
      were supported by other sites in the London Air Quality Network (LAQN). From
      these, a robust set of baseline air quality data was produced. Data from
      automatic and manual traffic counters as well as automatic license-plate
      recognition cameras were used to compile detailed vehicle profiles. This enabled 
      us to establish more precise associations between ambient pollutant
      concentrations and vehicle emissions. An additional goal of the study was to
      collect baseline PM data in order to test the hypothesis that changes in traffic 
      densities and vehicle mixes caused by the LEZ would affect the oxidative
      potential and metal content of ambient PM10 and PM2.5. The resulting baseline PM 
      data set was the first to describe, in detail, the oxidative potential and metal 
      content of the PM10 and PM2.5 of a major city's airshed. PM in London has
      considerable oxidative potential; clear differences in this measure were found
      from site to site, with evidence that the oxidative potential of both PM10 and
      PM2.5 at roadside monitoring sites was higher than at urban background locations.
      In the PM10 samples this increased oxidative activity appeared to be associated
      with increased concentrations of copper (Cu), barium (Ba), and
      bathophenanthroline disulfonate-mobilized iron (BPS Fe) in the roadside samples. 
      In the PM2.5 samples, no simple association could be seen, suggesting that other 
      unmeasured components were driving the increased oxidative potential in this
      fraction of the roadside samples. These data suggest that two components were
      contributing to the oxidative potential of roadside PM, namely Cu and BPS Fe in
      the coarse fraction of PM (PM with an aerodynamic diameter of 2.5 microm to 10
      microm; PM(2.5-10)) and an unidentified redox catalyst in PM2.5. The data derived
      for this baseline study confirmed key observations from a more limited spatial
      mapping exercise published in our earlier HEI report on the introduction of the
      London's Congestion Charging Scheme (CCS) in 2003 (Kelly et al. 2011a,b). In
      addition, the data set in the current report provided robust baseline information
      on the oxidative potential and metal content of PM found in the London airshed in
      the period before implementation of the LEZ; the finding that a proportion of the
      oxidative potential appears in the PM coarse mode and is apparently related to
      brake wear raises important issues regarding the nature of traffic management
      schemes. The final goal of this baseline study was to establish the feasibility, 
      in ethical and operational terms, of using the U.K.'s electronic primary-care
      records to evaluate the effects of the LEZ on human health outcomes. Data on
      consultations and prescriptions were compiled from a pilot group of general
      practices (13 distributed across London, with 100,000 patients; 29 situated in
      the inner London Borough of Lambeth, with 200,000 patients). Ethics approvals
      were obtained to link individual primary-care records to modeled NOx
      concentrations by means of post-codes. (To preserve anonymity, the postcodes were
      removed before delivery to the research team.) A wide range of NOx exposures was 
      found across London as well as within and between the practices examined.
      Although we observed little association between NOx exposure and smoking status, 
      a positive relationship was found between exposure and increased socioeconomic
      deprivation. The health outcomes we chose to study were asthma, chronic
      obstructive pulmonary disease, wheeze, hay fever, upper and lower respiratory
      tract infections, ischemic heart disease, heart failure, and atrial fibrillation.
      These outcomes were measured as prevalence or incidence. Their distributions by
      age, sex, socioeconomic deprivation, ethnicity, and smoking were found to accord 
      with those reported in the epidemiology literature. No cross-sectional positive
      associations were found between exposure to NOx and any of the studied health
      outcomes; some associations were significantly negative. After the pilot study, a
      suitable primary-care database of London patients was identified, the General
      Practice Research Database responsible for giving us access to these data agreed 
      to collaborate in the evaluation of the LEZ, and an acceptable method of ensuring
      privacy of the records was agreed upon. The database included about 350,000
      patients who had remained at the same address over the four-year period of the
      study. Power calculations for a controlled longitudinal analysis were then
      performed, indicating that for outcomes such as consultations for respiratory
      illnesses or prescriptions for asthma there was sufficient power to identify a 5%
      to 10% reduction in consultations for patients most exposed to the intervention
      compared with patients presumed to not be exposed to it. In conclusion, the work 
      undertaken in this study provides a good foundation for future LEZ evaluations.
      Our extensive monitoring network, measuring a comprehensive set of pollutants
      (and a range of particle metrics), will continue to provide a valuable tool both 
      for assessing the impact of LEZ regulations on air quality in London and for
      furthering understanding of the link between PM's composition and toxicity.
      Finally, we believe that in combination with our modeling of the predicted
      population-based changes in pollution exposure in London, the use of primary-care
      databases forms a sound basis and has sufficient statistical power for the
      evaluation of the potential impact of the LEZ on human health.
FAU - Kelly, Frank
AU  - Kelly F
AD  - School of Biomedical & Health Sciences, King's College London, 150 Stamford
      Street, London SE1 9NH, UK. frank.kelly@kcl.ac.uk
FAU - Armstrong, Ben
AU  - Armstrong B
FAU - Atkinson, Richard
AU  - Atkinson R
FAU - Anderson, H Ross
AU  - Anderson HR
FAU - Barratt, Ben
AU  - Barratt B
FAU - Beevers, Sean
AU  - Beevers S
FAU - Cook, Derek
AU  - Cook D
FAU - Green, Dave
AU  - Green D
FAU - Derwent, Dick
AU  - Derwent D
FAU - Mudway, Ian
AU  - Mudway I
FAU - Wilkinson, Paul
AU  - Wilkinson P
CN  - HEI Health Review Committee
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Res Rep Health Eff Inst
JT  - Research report (Health Effects Institute)
JID - 8812230
RN  - 0 (Air Pollutants)
RN  - 0 (Metals)
RN  - 0 (Nitrogen Oxides)
RN  - 0 (Particulate Matter)
RN  - 0 (Vehicle Emissions)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Air Pollutants/*analysis
MH  - Air Pollution/*analysis
MH  - Child
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Environmental Exposure/analysis
MH  - Environmental Monitoring/methods
MH  - Female
MH  - Health Status
MH  - Humans
MH  - Infant
MH  - London
MH  - Longitudinal Studies
MH  - Male
MH  - Metals/analysis
MH  - Middle Aged
MH  - Nitrogen Oxides/*analysis
MH  - Particulate Matter/*analysis
MH  - Pilot Projects
MH  - Primary Health Care/statistics & numerical data
MH  - Small-Area Analysis
MH  - Smoking
MH  - Socioeconomic Factors
MH  - Vehicle Emissions/*analysis
MH  - Young Adult
EDAT- 2012/02/10 06:00
MHDA- 2012/03/01 06:00
CRDT- 2012/02/10 06:00
PHST- 2012/02/10 06:00 [entrez]
PHST- 2012/02/10 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
PST - ppublish
SO  - Res Rep Health Eff Inst. 2011 Nov;(163):3-79.


PMID- 22315905
OWN - NLM
STAT- MEDLINE
DCOM- 20120320
LR  - 20120209
IS  - 0002-8045 (Print)
IS  - 0002-8045 (Linking)
VI  - 96
IP  - 6
DP  - 2011 Jun
TI  - Disclosing sleep: an ethical challenge from the eFAcs.org. Ethical issues in
      surgery community.
PG  - 20-1
FAU - Keune, Jason D
AU  - Keune JD
AD  - Department of Surgery, Washington University, St. Louis, MO, USA.
FAU - Kodner, Ira J
AU  - Kodner IJ
FAU - Healy, Gerald B
AU  - Healy GB
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Bull Am Coll Surg
JT  - Bulletin of the American College of Surgeons
JID - 7507024
MH  - *General Surgery
MH  - Humans
MH  - *Sleep
MH  - Truth Disclosure/*ethics
MH  - United States
EDAT- 2012/02/10 06:00
MHDA- 2012/03/21 06:00
CRDT- 2012/02/10 06:00
PHST- 2012/02/10 06:00 [entrez]
PHST- 2012/02/10 06:00 [pubmed]
PHST- 2012/03/21 06:00 [medline]
PST - ppublish
SO  - Bull Am Coll Surg. 2011 Jun;96(6):20-1.


PMID- 22315856
OWN - NLM
STAT- MEDLINE
DCOM- 20120308
LR  - 20120209
IS  - 0019-5847 (Print)
IS  - 0019-5847 (Linking)
VI  - 109
IP  - 8
DP  - 2011 Aug
TI  - Ethically yours .....
PG  - 532-3
FAU - Nath, Nemai C
AU  - Nath NC
LA  - eng
PT  - Editorial
PL  - India
TA  - J Indian Med Assoc
JT  - Journal of the Indian Medical Association
JID - 7505608
SB  - IM
MH  - *Ethics, Medical
MH  - General Surgery/ethics
MH  - Humans
MH  - Informed Consent
EDAT- 2012/02/10 06:00
MHDA- 2012/03/09 06:00
CRDT- 2012/02/10 06:00
PHST- 2012/02/10 06:00 [entrez]
PHST- 2012/02/10 06:00 [pubmed]
PHST- 2012/03/09 06:00 [medline]
PST - ppublish
SO  - J Indian Med Assoc. 2011 Aug;109(8):532-3.


PMID- 22315600
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1687-8647 (Electronic)
IS  - 1687-8639 (Linking)
VI  - 2011
DP  - 2011
TI  - Phylogeny-directed search for murine leukemia virus-like retroviruses in
      vertebrate genomes and in patients suffering from myalgic
      encephalomyelitis/chronic fatigue syndrome and prostate cancer.
PG  - 341294
LID - 10.1155/2011/341294 [doi]
AB  - Gammaretrovirus-like sequences occur in most vertebrate genomes. Murine Leukemia 
      Virus (MLV) like retroviruses (MLLVs) are a subset, which may be pathogenic and
      spread cross-species. Retroviruses highly similar to MLLVs (xenotropic murine
      retrovirus related virus (XMRV) and Human Mouse retrovirus-like RetroViruses
      (HMRVs)) reported from patients suffering from prostate cancer (PC) and myalgic
      encephalomyelitis/chronic fatigue syndrome (ME/CFS) raise the possibility that
      also humans have been infected. Structurally intact, potentially infectious MLLVs
      occur in the genomes of some mammals, especially mouse. Mouse MLLVs contain three
      major groups. One, MERV G3, contained MLVs and XMRV/HMRV. Its presence in mouse
      DNA, and the abundance of xenotropic MLVs in biologicals, is a source of false
      positivity. Theoretically, XMRV/HMRV could be one of several MLLV transspecies
      infections. MLLV pathobiology and diversity indicate optimal strategies for
      investigating XMRV/HMRV in humans and raise ethical concerns. The alternatives
      that XMRV/HMRV may give a hard-to-detect "stealth" infection, or that XMRV/HMRV
      never reached humans, have to be considered.
FAU - Blomberg, Jonas
AU  - Blomberg J
AD  - Section of Clinical Microbiology, Department of Medical Sciences, Uppsala
      University, 751 05 Uppsala, Sweden.
FAU - Sheikholvaezin, Ali
AU  - Sheikholvaezin A
FAU - Elfaitouri, Amal
AU  - Elfaitouri A
FAU - Blomberg, Fredrik
AU  - Blomberg F
FAU - Sjosten, Anna
AU  - Sjosten A
FAU - Mattson Ulfstedt, Johan
AU  - Mattson Ulfstedt J
FAU - Pipkorn, Rudiger
AU  - Pipkorn R
FAU - Kallander, Clas
AU  - Kallander C
FAU - Ohrmalm, Christina
AU  - Ohrmalm C
FAU - Sperber, Goran
AU  - Sperber G
LA  - eng
PT  - Journal Article
DEP - 20110904
PL  - United States
TA  - Adv Virol
JT  - Advances in virology
JID - 101508613
PMC - PMC3265301
EDAT- 2012/02/09 06:00
MHDA- 2012/02/09 06:01
CRDT- 2012/02/09 06:00
PHST- 2011/04/17 00:00 [received]
PHST- 2011/06/11 00:00 [revised]
PHST- 2011/06/22 00:00 [accepted]
PHST- 2012/02/09 06:00 [entrez]
PHST- 2012/02/09 06:00 [pubmed]
PHST- 2012/02/09 06:01 [medline]
AID - 10.1155/2011/341294 [doi]
PST - ppublish
SO  - Adv Virol. 2011;2011:341294. doi: 10.1155/2011/341294. Epub 2011 Sep 4.


PMID- 22312969
OWN - NLM
STAT- MEDLINE
DCOM- 20120228
LR  - 20131121
IS  - 0465-5893 (Print)
IS  - 0465-5893 (Linking)
VI  - 62
IP  - 5
DP  - 2011
TI  - [Effects of marijuana and amphetamine (and its derivatives on driving performance
      based on the driving simulator studies].
PG  - 551-63
AB  - This article presents the results of the driving simulator studies of the effects
      of marijuana and amphetamines on driving performance. The majority of these
      studies have been focused on identifying the impact of the tested substances on
      cognitive and psychomotor functions. Most of the findings on marijuana reveal its
      modest effect on driving ability that increases with the increasing frequency of 
      its use and when used in conjuction with other drugs and alcohol. Similarly,
      small doses of amphetamines can cause a positive stimulating effect, improving
      certain cognitive functions, such as vigilance, but it decreases when they are
      overused and combined with alcohol. The results of the research on drivers'
      behavior under the influence of amphetamines also indicate deficits in their
      cognitive functions and tendency to recklessness on the road. The authors also
      discuss strong and weak points of simulation studies of the effects of
      psychoactive substances on the driving ability. An attempt was also made to
      clarify certain ambiguities, which occur in this field of research. A central
      role of the ethical and methodological limitations of simulation studies were
      discussed as well.
FAU - Drabek, Marcin
AU  - Drabek M
AD  - Zaklad Psychologii Pracy, Instytut Medycyny Pracy im. prof. J. Nofera, Lodz.
      drabek@imp.lodz.pl
FAU - Andysz, Aleksandra
AU  - Andysz A
LA  - pol
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Wplyw zazywania marihuany i amfetaminy (oraz jej pochodnych) na prowadzenie
      pojazdow na podstawie wynikow badan symulatorowych.
PL  - Poland
TA  - Med Pr
JT  - Medycyna pracy
JID - 0376642
RN  - 0 (Central Nervous System Stimulants)
RN  - CK833KGX7E (Amphetamine)
SB  - IM
MH  - Accidents, Traffic/prevention & control
MH  - Amphetamine/*adverse effects
MH  - Amphetamine-Related Disorders/*complications
MH  - *Automobile Driving
MH  - Cannabis/*adverse effects
MH  - Central Nervous System Stimulants/*adverse effects
MH  - Cognition/drug effects
MH  - *Computer Simulation
MH  - Humans
MH  - Psychomotor Performance/*drug effects
MH  - Task Performance and Analysis
EDAT- 2012/02/09 06:00
MHDA- 2012/03/01 06:00
CRDT- 2012/02/09 06:00
PHST- 2012/02/09 06:00 [entrez]
PHST- 2012/02/09 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
PST - ppublish
SO  - Med Pr. 2011;62(5):551-63.


PMID- 22312846
OWN - NLM
STAT- MEDLINE
DCOM- 20120308
LR  - 20161206
IS  - 1210-7832 (Print)
IS  - 1210-7832 (Linking)
VI  - 76
IP  - 6
DP  - 2011 Dec
TI  - [Transurethral injection of polyacrylamide hydrogel (Bulkamid) for the treatment 
      of female stress urinary inkontinence and changes in the cure rate over time].
PG  - 476-81
AB  - OBJECTIVE: The objective of this study was to evaluate short term and long term
      efficacy of a transurethral injection (TUI) using bulking agent Bulkamid for
      female stress and mixed urinary incontinence. The hypothesis was that the cure
      rate of Bulkamid may slowly decreases over time. DESIGN: Retrospective clinical
      study. SETTINGS: Gynecological and Obstetric Clinic, 1 LF UK and VFN, Prague.
      MATERIALS AND METHODS: A retrospective study was performed on 25 women with
      urinary incontinence (stress 18; mixed 7), and 24 patients completed the study.
      Nineteen patients had previously undergone anti-incontinence surgery. The
      efficacy of TUI was evaluated 3 months (+/- 1 week) and an average of 13.5 months
      (range 6-30 months) after surgery. Subjective assessment of the leakage of urine 
      was based on the International Consultation on Incontinence Questionnaire - Short
      form (ICIQ-UI SF) filled in before and three and - on average - 13.5 months after
      the surgery (minimum time after surgery was 6 months). Improvement in urinary
      incontinence was defined as a drop in the score of more than 50%. Objective
      assessment of leakage of urine was assessed by cough test. Ethical committee
      approval was obtained, and all subjects gave written informed consent to
      participate in the study. RESULTS: Mean age of patients was 69.7 (SD 16.22)
      years, mean body mass index (BMI) 27.56 (SD 3.42), and mean parity was 1.73 (SD
      0.7). Objective assessment by cough test showed that 9/25 (36%) of patients had
      negative results for this test 3 months and 4/24 (16.7%) 13.5 months after the
      operation. Subjective assessment by the ICIQ-UI SF questionnaire showed that 7/25
      (28%) of our patients were completely dry 3 months after the operation and 3/24
      (12,5%) 13 months after the operation. 20/25 (80%) of patients were dry or
      improved 3 months after the operation and 14/24 (58.3%) 13.5 months after the
      operation. The mean score before the operation was 17.56 (SD 3.44), median 18; 3 
      months after the operation it was 5.68 (SD 5.51), median 5; and 13.5 months after
      the operation it was 8.25 (SD 5.49), median 7.5. The evaluation of the answers to
      the question "Overall, how much does leaking urine interfere with your everyday
      life?" showed a worsening of the situation to a statistical significant degree: 3
      months after the operation the mean score was 2.38 (SD 2.28), while 13.5 months
      after the operation it was 3.79 (SD 2.96). CONCLUSIONS: The hypothesis that the
      cure rate of Bulkamid may slowly decreases as time passes after the operation was
      confirmed.
FAU - Martan, A
AU  - Martan A
AD  - Gynekologicko-porodnicka klinika VFN a 1. LF UK, Praha. martan@vfn.cz
FAU - Masata, J
AU  - Masata J
FAU - Svabik, K
AU  - Svabik K
FAU - El-Haddad, R
AU  - El-Haddad R
FAU - Hubka, P
AU  - Hubka P
LA  - cze
PT  - English Abstract
PT  - Journal Article
TT  - Zmeny lecebneho efektu transuretralni aplikace polyakrylamid hydrogelu
      (Bulkamidu) pri lecbe zenske stresove inkontinence moci v zavislosti na case od
      operace.
PL  - Czech Republic
TA  - Ceska Gynekol
JT  - Ceska gynekologie
JID - 9423768
RN  - 0 (Acrylic Resins)
RN  - 0 (Biocompatible Materials)
RN  - 0 (Bulkamid)
RN  - 0 (Hydrogels)
SB  - IM
MH  - Acrylic Resins/*administration & dosage
MH  - Aged
MH  - Biocompatible Materials/*administration & dosage
MH  - Female
MH  - Humans
MH  - Hydrogels/*administration & dosage
MH  - Injections
MH  - Treatment Outcome
MH  - Urethra
MH  - Urinary Incontinence, Stress/*therapy
EDAT- 2012/02/09 06:00
MHDA- 2012/03/09 06:00
CRDT- 2012/02/09 06:00
PHST- 2012/02/09 06:00 [entrez]
PHST- 2012/02/09 06:00 [pubmed]
PHST- 2012/03/09 06:00 [medline]
PST - ppublish
SO  - Ceska Gynekol. 2011 Dec;76(6):476-81.


PMID- 22312224
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1179-1594 (Electronic)
IS  - 1179-1594 (Linking)
VI  - 4
DP  - 2011
TI  - Confidentiality of the medical records of HIV-positive patients in the United
      Kingdom - a medicolegal and ethical perspective.
PG  - 15-26
LID - 10.2147/RMHP.S8997 [doi]
AB  - This article examines the legal and ethical issues that surround the
      confidentiality of medical records, particularly in relation to patients who are 
      HIV positive. It records some historical background of the HIV epidemic, and
      considers the relative risks of transmission of HIV from individual to
      individual. It explains the law as it pertains to confidentiality, and reports
      the professional guidance in these matters. It then considers how these relate to
      HIV-positive individuals in particular.
FAU - Williams, Mike
AU  - Williams M
AD  - Head of Service, Cambridge, University Dental Service, Cambridge, UK.
LA  - eng
PT  - Journal Article
DEP - 20110126
PL  - England
TA  - Risk Manag Healthc Policy
JT  - Risk management and healthcare policy
JID - 101566264
PMC - PMC3270929
OTO - NOTNLM
OT  - HIV/AIDS
OT  - confidentiality
OT  - medical records
EDAT- 2012/02/09 06:00
MHDA- 2012/02/09 06:01
CRDT- 2012/02/08 06:00
PHST- 2012/02/08 06:00 [entrez]
PHST- 2012/02/09 06:00 [pubmed]
PHST- 2012/02/09 06:01 [medline]
AID - 10.2147/RMHP.S8997 [doi]
AID - rmhp-4-015 [pii]
PST - ppublish
SO  - Risk Manag Healthc Policy. 2011;4:15-26. doi: 10.2147/RMHP.S8997. Epub 2011 Jan
      26.


PMID- 22304726
OWN - NLM
STAT- MEDLINE
DCOM- 20130401
LR  - 20120206
IS  - 0033-0205 (Print)
IS  - 0033-0205 (Linking)
VI  - 64
IP  - 4
DP  - 2011 Oct-Dec
TI  - [Planning and activation of a nursing consultancy service with formal recognition
      inside the San Giovanni Bosco Hospital of Turin].
PG  - 219-28
AB  - In some countries the figure of the Consultant Nurse already exists. The
      literature highlights the experience of the United Kingdom has formally defined
      the role and profile. In Italy there are few experiences in this area and all
      local initiative, although the Code of Ethics recognizes the nurse the
      opportunity to engage in counseling. In the Hospital San Giovanni Bosco di Torino
      as a result of increased complexity of patients to be treated has been developed 
      at the informal advisory nursing. The aim of this paper is to describe the
      methodology used for the realization of plans to activate a service of advice
      nursing, recognized, in the Presidio and to present the results achieved from its
      application. It is a working group, reviewed the literature and shared the
      definition of "Nurse Consultant". This is done to administration of a validated
      questionnaire to map the types of assistance required and paid and payable,
      graduation of the types detected by means of a weighing system based on
      frequency, urgency and seriousness, elaboration of the structure of each profile 
      with the declination of the requirements enabling focus groups with experienced
      professionals, develop a procedure for the activation of the advice and the
      schedule training. Results are identification of 5 types of advice and drafting
      of the profile priority, establishment of requirements for the suitability of
      staff to cover the position and drafting an operating procedure which governs the
      operation of the service within the Presidio.
FAU - Finiguerra, Ivana
AU  - Finiguerra I
AD  - Ospedaliero San Giovanni Bosco, ASLTO2, Torino.
FAU - Simone, Paola
AU  - Simone P
FAU - Fuggetta, Leonardo
AU  - Fuggetta L
FAU - Latona, Serafina
AU  - Latona S
FAU - Di Michele, Simonetta
AU  - Di Michele S
FAU - Maina, Luca
AU  - Maina L
FAU - Gianino, Maria Michela
AU  - Gianino MM
LA  - ita
PT  - English Abstract
PT  - Journal Article
TT  - Progettazione e attivazione di un servizio di consulenza infermieristica
      formalmente riconosciuto all'interno del presidio ospedaliero San Giovanni Bosco 
      di Torino.
PL  - Italy
TA  - Prof Inferm
JT  - Professioni infermieristiche
JID - 0244135
MH  - *Consultants
MH  - *Hospitals
MH  - Humans
MH  - Italy
MH  - *Nursing
MH  - *Nursing Staff, Hospital
EDAT- 2012/02/07 06:00
MHDA- 2013/04/02 06:00
CRDT- 2012/02/07 06:00
PHST- 2012/02/07 06:00 [entrez]
PHST- 2012/02/07 06:00 [pubmed]
PHST- 2013/04/02 06:00 [medline]
PST - ppublish
SO  - Prof Inferm. 2011 Oct-Dec;64(4):219-28.


PMID- 22303801
OWN - NLM
STAT- MEDLINE
DCOM- 20120306
LR  - 20120206
IS  - 1015-8146 (Print)
IS  - 1015-8146 (Linking)
VI  - 22
IP  - 4
DP  - 2011
TI  - Opinions of Turkish physicians towards termination of pregnancy for fetal
      disorders.
PG  - 401-9
AB  - Termination of pregnancy (ToP) raises ethical dilemmas. Although ToP for fetal
      disorders is commonly approved by health professionals, their opinions and
      attitudes are influenced by a diversity of cultural contexts. The aim of the
      study is to investigate Turkish physicians' opinions on ToP for fetal disease and
      the hypothesis is that their opinions are influenced by whether they face any
      disabilities of affected children or not. We aimed to survey by a questionnaire
      the opinions of Turkish physicians towards ToP for untreatable fetal disorders. A
      group of 250 subjects was included in the study. Physicians' approval of parents'
      decision for ToP was higher for disorders that they encounter more frequently
      during their daily work. Their opinions were not statistically different when
      compared for gender and marital status, however, having children of their own
      caused significant differences for some of the disorders. Approximately 65% of
      the participants responded that families alone should have the right to decide on
      ToP. The results confirm that health professionals may have differences in
      perception of severity of diseases, based on their clinical experience.
      Physicians encountering affected children more likely approve ToP for that
      particular disease.
FAU - Utine, G E
AU  - Utine GE
AD  - Hacettepe University Faculty of Medicine, Department of Pediatrics, Clinical
      Genetics Unit, Ankara, Turkey. geutine@hacettepe.edu.tr
FAU - Kiper, P O
AU  - Kiper PO
FAU - Salanci, B V
AU  - Salanci BV
FAU - Alanay, Y
AU  - Alanay Y
FAU - Aktas, D
AU  - Aktas D
FAU - Alikasifoglu, M
AU  - Alikasifoglu M
FAU - Boduroglu, K
AU  - Boduroglu K
FAU - Tuncbilek, E
AU  - Tuncbilek E
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Genet Couns
JT  - Genetic counseling (Geneva, Switzerland)
JID - 9015261
SB  - IM
MH  - Abortion, Eugenic/*ethics
MH  - *Attitude of Health Personnel
MH  - Data Collection
MH  - Decision Making
MH  - *Ethics, Medical
MH  - Female
MH  - Fetal Diseases/*diagnosis
MH  - General Practice
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - Medicine
MH  - Pregnancy
MH  - Students, Medical/*psychology
MH  - Turkey
EDAT- 2012/02/07 06:00
MHDA- 2012/03/07 06:00
CRDT- 2012/02/07 06:00
PHST- 2012/02/07 06:00 [entrez]
PHST- 2012/02/07 06:00 [pubmed]
PHST- 2012/03/07 06:00 [medline]
PST - ppublish
SO  - Genet Couns. 2011;22(4):401-9.


PMID- 22303773
OWN - NLM
STAT- MEDLINE
DCOM- 20120405
LR  - 20211021
IS  - 0016-9161 (Print)
IS  - 0016-9161 (Linking)
VI  - 68
IP  - 1
DP  - 2011
TI  - Doctors in court, honour, and professional ethics: two scandals in Imperial
      Germany.
PG  - 61-79
AB  - Comparing two public medical affairs which involved disciplinary proceedings and 
      libel actions, one from Bavaria and one from Prussia, this article analyzes the
      dynamics behind legal conflicts over doctors' professional ethics in Imperial
      Germany. In both the case of Dr Maurice Hutzler, who committed suicide after
      conflicts with senior colleagues at the Gisela Children's Hospital and a sentence
      of the court of honour of the Munich Medical District Society, and the Berlin
      "patient trade" affair, in which the medical professors Ernst von Leyden, Hermann
      Senator, Karl Anton Ewald and Carl Posner were accused of having made payments to
      middlemen for bringing them lucrative private patients, notions of personal and
      professional honour played a central role. The Munich case highlighted
      shortcomings of the Bavarian medical court of honour system, which was less
      developed than its Prussian counterpart. The analysis of the two cases suggests
      that the ethics of medical practice in early twentieth-century Germany should be 
      viewed as part of a culture of honour.
FAU - Maehle, Andreas-Holger
AU  - Maehle AH
AD  - Wolfson Research Institute, Durham University, Queen's Campus, Stockton TS17 6BH,
      United Kingdom. a.h.maehle@durham.ac.uk
LA  - eng
GR  - 082800/WT_/Wellcome Trust/United Kingdom
PT  - Biography
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Gesnerus
JT  - Gesnerus
JID - 1257130
SB  - IM
MH  - Ethics, Medical/*history
MH  - *Expert Testimony
MH  - *Famous Persons
MH  - Germany
MH  - History, 19th Century
MH  - History, 20th Century
MH  - Humans
MH  - Prussia
MH  - Suicide/*history
PS  - Hutzler M
FPS - Hutzler, Maurice
PMC - PMC3696867
MID - EMS53757
OID - NLM: EMS53757
EDAT- 2012/02/07 06:00
MHDA- 2012/04/06 06:00
CRDT- 2012/02/07 06:00
PHST- 2012/02/07 06:00 [entrez]
PHST- 2012/02/07 06:00 [pubmed]
PHST- 2012/04/06 06:00 [medline]
PST - ppublish
SO  - Gesnerus. 2011;68(1):61-79.


PMID- 22303600
OWN - NLM
STAT- MEDLINE
DCOM- 20120302
LR  - 20191210
IS  - 1220-4749 (Print)
IS  - 1220-4749 (Linking)
VI  - 49
IP  - 2
DP  - 2011
TI  - IL28B polymorphism -- predictive factor of HCV infected genotype 1 individuals to
      treatment response and management of therapy.
PG  - 99-104
AB  - It is estimated that approximately 3% of the world population are chronically
      infected with HCV, as the annual incidence of HCV infection is approximately 3-4 
      million people. Despite all efforts made to eradicate the HCV infection, after
      the standard therapy (PegIFN and ribavirin for 48 weeks) only 40-50% of the HCV
      infected individuals with genotype 1 achieve sustained virological response
      (SVR). Since our goal today is the eradication of HCV infection, our prior
      concern has become the identification of predictor factors concerning treatment
      response. Recent studies such as GWAS have been concerned with the genetic
      factors and the response to treatment. Recently all interest has been turned
      towards the demonstration of the host polymorphism located upstream of the IL-28B
      gene and which is associated with sustained virological response to treatment
      with pegylated interferon Alfa in combination with ribavirin. Although 2011 comes
      with the FDA approval of the new triple therapy associating telaprevir/
      boceprevir to the standard therapy, a new ethical concern regarding the high
      costs of this treatment rises the problem of who is the first in line? This is
      just the beginning of a new quest to further investigate the relationship between
      the host's polymorphism of the IL-28 gene and the standard and triple therapy in 
      HCV infected individuals in achieving SVR as well as who should receive standard 
      or triple therapy. Determination of the IL-28 polymorphisms may be used together 
      with clinical assessment in order to evaluate patients and to personalize their
      treatment. The purpose of this paper is to underline the main concerns regarding 
      the goal and endpoints of the HCV therapy, and the relationship of IL-28 in
      achieving sustained virological response, as well as in pointing out the
      importance to determine prior to initiating treatment the polymorphism of IL-28
      since it is a strong predictor. This is important because it will increase the
      chances to achieve SVR, it will be cost-effective and reduces adverse effects.
FAU - Ionita-Radu, Florentina
AU  - Ionita-Radu F
AD  - "Dr. Carol Davila" Central Universitary Emergency Military Hospital, Bucharest,
      Romania. fionita04@yahoo.com
FAU - Rascanu, Aida
AU  - Rascanu A
FAU - Cheiab, Bianca
AU  - Cheiab B
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Rom J Intern Med
JT  - Romanian journal of internal medicine = Revue roumaine de medecine interne
JID - 9304507
RN  - 0 (Antiviral Agents)
RN  - 0 (Biomarkers)
RN  - 0 (IFNL3 protein, human)
RN  - 0 (Interferon-alpha)
RN  - 0 (Interleukins)
RN  - 0 (Oligopeptides)
RN  - 0 (Recombinant Proteins)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 49717AWG6K (Ribavirin)
RN  - 655M5O3W0U (telaprevir)
RN  - 89BT58KELH
      (N-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amin
      o)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-
      2-carboxamide)
RN  - 9008-11-1 (Interferons)
RN  - 9DLQ4CIU6V (Proline)
RN  - Q46947FE7K (peginterferon alfa-2a)
SB  - IM
MH  - Antiviral Agents/*therapeutic use
MH  - Biomarkers/blood
MH  - Drug Therapy, Combination
MH  - Genotype
MH  - *Hepacivirus/drug effects
MH  - Hepatitis C/diagnosis/*drug therapy/*genetics
MH  - Humans
MH  - Interferon-alpha/*therapeutic use
MH  - Interferons
MH  - Interleukins/*genetics
MH  - Oligopeptides/therapeutic use
MH  - Polyethylene Glycols/*therapeutic use
MH  - *Polymorphism, Genetic
MH  - Predictive Value of Tests
MH  - Proline/analogs & derivatives/therapeutic use
MH  - Recombinant Proteins/therapeutic use
MH  - Ribavirin/*therapeutic use
MH  - Risk Assessment
MH  - Sensitivity and Specificity
MH  - Treatment Outcome
EDAT- 2012/02/07 06:00
MHDA- 2012/03/03 06:00
CRDT- 2012/02/07 06:00
PHST- 2012/02/07 06:00 [entrez]
PHST- 2012/02/07 06:00 [pubmed]
PHST- 2012/03/03 06:00 [medline]
PST - ppublish
SO  - Rom J Intern Med. 2011;49(2):99-104.


PMID- 22303053
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1998-3743 (Electronic)
IS  - 0250-474X (Linking)
VI  - 73
IP  - 2
DP  - 2011 Mar
TI  - Ethics in clinical research: the Indian perspective.
PG  - 125-30
AB  - Ethics in clinical research focuses largely on identifying and implementing the
      acceptable conditions for exposure of some individuals to risks and burdens for
      the benefit of society at large. Ethical guidelines for clinical research were
      formulated only after discovery of inhumane behaviour with participants during
      research experiments. The Nuremberg Code was the first international code laying 
      ethical principles for clinical research. With increasing research all over,
      World Health Organization formulated guidelines in the form of Declaration of
      Helsinki in 1964. The US laid down its guidelines for ethical principles in the
      Belmont Report after discovery of the Tuskegee's Syphilis study. The Indian
      Council of Medical Research has laid down the 'Ethical Guidelines for Biomedical 
      Research on Human Subjects' in the year 2000 which were revised in 2006. It gives
      twelve general principles to be followed by all biomedical researchers working in
      the country. The Ethics Committee stands as the bridge between the researcher and
      the ethical guidelines of the country. The basic responsibility of the Ethics
      Committee is to ensure an independent, competent and timely review of all ethical
      aspects of the project proposals received in order to safeguard the dignity,
      rights, safety and well-being of all actual or potential research participants. A
      well-documented informed consent process is the hallmark of any ethical research 
      work. Informed consent respects individual's autonomy, to participate or not to
      participate in research. Concepts of vulnerable populations, therapeutic
      misconception and post trial access hold special importance in ethical conduct of
      research, especially in developing countries like India, where most of the
      research participants are uneducated and economically backward.
FAU - Sanmukhani, J
AU  - Sanmukhani J
AD  - Department of Pharmacology, Government Medical College, Bhavnagar-364 001, India.
FAU - Tripathi, C B
AU  - Tripathi CB
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Pharm Sci
JT  - Indian journal of pharmaceutical sciences
JID - 7809431
PMC - PMC3267294
OTO - NOTNLM
OT  - Clinical research
OT  - ICMR guidelines
OT  - ethics
OT  - ethics committees
OT  - informed consent
EDAT- 2012/02/04 06:00
MHDA- 2012/02/04 06:01
CRDT- 2012/02/04 06:00
PHST- 2010/06/21 00:00 [received]
PHST- 2011/01/14 00:00 [revised]
PHST- 2011/03/01 00:00 [accepted]
PHST- 2012/02/04 06:00 [entrez]
PHST- 2012/02/04 06:00 [pubmed]
PHST- 2012/02/04 06:01 [medline]
AID - 10.4103/0250-474x.91564 [doi]
PST - ppublish
SO  - Indian J Pharm Sci. 2011 Mar;73(2):125-30. doi: 10.4103/0250-474x.91564.


PMID- 22301706
OWN - NLM
STAT- MEDLINE
DCOM- 20120802
LR  - 20211203
IS  - 1661-6758 (Electronic)
IS  - 1661-6499 (Linking)
VI  - 4
IP  - 6
DP  - 2011
TI  - Inclusion and exclusion in nutrigenetics clinical research: ethical and
      scientific challenges.
PG  - 322-43
LID - 10.1159/000334853 [doi]
AB  - BACKGROUND/AIMS: There are compelling reasons to ensure the participation of
      ethnic minorities and populations of all ages worldwide in nutrigenetics clinical
      research. If findings in such research are valid for some individuals, groups, or
      communities, and not for others, then ethical questions of justice--and not only 
      issues of methodology and external validity--arise. This paper aims to examine
      inclusion in nutrigenetics clinical research and its scientific and ethical
      challenges. METHODS: In total, 173 publications were identified through a
      systematic review of clinical studies in nutrigenetics published between 1998 and
      2007. Data such as participants' demographics as well as eligibility criteria
      were extracted. RESULTS: There is no consistency in the way participants' origins
      (ancestry, ethnicity, or race) and ages are described in publications. A vast
      majority of the studies identified was conducted in North America and Europe and 
      focused on 'white' participants. Our results show that pregnant women (and
      fetuses), minors, and the elderly (>/= 75 years old) remain underrepresented.
      CONCLUSION: Representativeness in nutrigenetics research is a challenging ethical
      and scientific issue. Yet, if nutrigenetics is to benefit whole populations and
      be used in public and global health agendas, fair representation as well as clear
      descriptions of participants in publications are crucial.
CI  - Copyright (c) 2012 S. Karger AG, Basel.
FAU - Hurlimann, T
AU  - Hurlimann T
AD  - Department of Social and Preventive Medicine, Bioethics Programmes, Faculty of
      Medicine, University of Montreal, Montreal, Que., Canada.
FAU - Stenne, R
AU  - Stenne R
FAU - Menuz, V
AU  - Menuz V
FAU - Godard, B
AU  - Godard B
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20120131
PL  - Switzerland
TA  - J Nutrigenet Nutrigenomics
JT  - Journal of nutrigenetics and nutrigenomics
JID - 101299758
SB  - IM
MH  - Bias
MH  - Biomedical Research/*ethics/methods/*standards/statistics & numerical data
MH  - Ethnicity/statistics & numerical data
MH  - Female
MH  - Humans
MH  - Minority Groups/statistics & numerical data
MH  - Nutrigenomics/*ethics/methods/*standards/statistics & numerical data
MH  - *Patient Selection/ethics
MH  - Pregnancy
MH  - Publishing/statistics & numerical data
EDAT- 2012/02/04 06:00
MHDA- 2012/08/03 06:00
CRDT- 2012/02/04 06:00
PHST- 2011/05/05 00:00 [received]
PHST- 2011/11/03 00:00 [accepted]
PHST- 2012/02/04 06:00 [entrez]
PHST- 2012/02/04 06:00 [pubmed]
PHST- 2012/08/03 06:00 [medline]
AID - 000334853 [pii]
AID - 10.1159/000334853 [doi]
PST - ppublish
SO  - J Nutrigenet Nutrigenomics. 2011;4(6):322-43. doi: 10.1159/000334853. Epub 2012
      Jan 31.


PMID- 22299439
OWN - NLM
STAT- MEDLINE
DCOM- 20120306
LR  - 20141120
IS  - 0125-1562 (Print)
IS  - 0125-1562 (Linking)
VI  - 42
IP  - 5
DP  - 2011 Sep
TI  - Accelerating the development of an AIDS vaccine: the AIDS vaccine for Asia
      Network (Avan).
PG  - 1130-46
AB  - HIV/AIDS is a major public health problem worldwide, especially in developing
      countries. The development of a safe and effective HIV vaccine is central to
      stopping the epidemic and would be a great public health tool. The AIDS Vaccine
      for Asia Network (AVAN) is a group of concerned investigators committed to
      assisting regional and global HIV vaccine efforts. AVAN's focus on improving the 
      coordination and harmonization of research, ethical reviews, clinical trial
      capacity, regulatory frameworks, vaccine manufacturing, community participation, 
      and government advocacy could help accelerate HIV vaccine efforts in the region. 
      At a meeting in November 2010, researchers from various countries in Asia
      presented their progress in HIV vaccine research and development. Six working
      groups discussed the current status, gaps and methods to strengthen capacity and 
      infrastructure in various areas related to AIDS vaccine research and development.
      These discussions led to the development of prioritized action plans for the next
      5 years. This report describes the gaps and challenges HIV vaccine research faces
      in the region and recommends improvement and standardization of facilities, and
      coordination and harmonization of all activities related to AIDS vaccine research
      and development, including possible technology transfer when a vaccine becomes
      available.
FAU - Pitisuttithum, Punnee
AU  - Pitisuttithum P
AD  - Faculty of Tropical Medicine, Mahidol University, Bangkok. tmppt@mahidol.ac.th
FAU - Rerks-Ngarm, Supachai
AU  - Rerks-Ngarm S
FAU - Chiu, Joseph
AU  - Chiu J
FAU - Kim, Jerome
AU  - Kim J
FAU - Benenson, Michael
AU  - Benenson M
FAU - Kent, Stephen J
AU  - Kent SJ
FAU - Tamashiro, Hiko
AU  - Tamashiro H
FAU - Manrique, Amapola
AU  - Manrique A
FAU - Bernstein, Alan
AU  - Bernstein A
FAU - Goyal, Rajat
AU  - Goyal R
FAU - Ditangco, Rossana A
AU  - Ditangco RA
FAU - Cooper, David A
AU  - Cooper DA
FAU - Osmanov, Saladin
AU  - Osmanov S
FAU - Mathieson, Bonnie
AU  - Mathieson B
FAU - Sandstrom, Eric
AU  - Sandstrom E
FAU - Esparza, Jose
AU  - Esparza J
FAU - Hoff, Rodney
AU  - Hoff R
FAU - Shao, Yiming
AU  - Shao Y
CN  - AIDS Vaccine for Asia Network
LA  - eng
PT  - Journal Article
PL  - Thailand
TA  - Southeast Asian J Trop Med Public Health
JT  - The Southeast Asian journal of tropical medicine and public health
JID - 0266303
RN  - 0 (AIDS Vaccines)
SB  - IM
MH  - *AIDS Vaccines
MH  - Asia/epidemiology
MH  - Biomedical Research/*organization & administration/standards
MH  - Clinical Trials as Topic
MH  - Developing Countries
MH  - *Global Health
MH  - HIV/*immunology
MH  - HIV Infections/epidemiology/immunology/*prevention & control
MH  - Humans
MH  - International Cooperation
EDAT- 2012/02/04 06:00
MHDA- 2012/03/07 06:00
CRDT- 2012/02/04 06:00
PHST- 2012/02/04 06:00 [entrez]
PHST- 2012/02/04 06:00 [pubmed]
PHST- 2012/03/07 06:00 [medline]
PST - ppublish
SO  - Southeast Asian J Trop Med Public Health. 2011 Sep;42(5):1130-46.


PMID- 22299319
OWN - NLM
STAT- MEDLINE
DCOM- 20120302
LR  - 20190923
IS  - 0001-5458 (Print)
IS  - 0001-5458 (Linking)
VI  - 111
IP  - 6
DP  - 2011 Nov-Dec
TI  - Legislation and refusal of blood transfusion by a minor Jehovah-Witness in
      Belgium.
PG  - 355-9
AB  - The refusal of blood transfusion by Jehovah's Witnesses in critical situations
      constitutes an ethical and juridical dilemma. The refusal to receive blood
      products by Jehovah's Witnesses is based on biblical verses. Recurring arguments 
      to sustain this refusal regard the right to self-determination and the right to
      freedom of faith. If minors are involved, the problem is rendered even more
      difficult as the parental authority over young children needs to be taken into
      account. When adolescents are concerned, the situation if even more ambiguous
      since adolescents might be considered as mature enough to provide autonomous
      consent. On the basis of three cases, the most frequent bottlenecks that can come
      up in paediatric emergency services are highlighted: (1) the refusal of a blood
      transfusion by the parents of a young child; (2) the refusal by an adolescent and
      (3) prior refusal based on a "No Blood"-document. Regarding minors, the law on
      patients' rights in Belgium contains safety mechanisms concerning the
      preservation of physical integrity. Therefore, a key responsibility has been
      assigned to the physician. A step-by-step plan and a synoptic diagram are
      presented.
FAU - Deneyer, M
AU  - Deneyer M
AD  - Department of Paediatrics, Universitair Kinderziekenhuis Brussels, Belgium.
FAU - Matthys, D
AU  - Matthys D
FAU - Ramet, J
AU  - Ramet J
FAU - Michel, L
AU  - Michel L
FAU - Holsters, D
AU  - Holsters D
FAU - Vandenplas, Y
AU  - Vandenplas Y
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - England
TA  - Acta Chir Belg
JT  - Acta chirurgica Belgica
JID - 0370571
SB  - IM
MH  - Accidents, Traffic/legislation & jurisprudence
MH  - Adolescent
MH  - Belgium
MH  - Blood Transfusion/ethics/*legislation & jurisprudence
MH  - Bronchiolitis/*therapy
MH  - Critical Care/ethics/*legislation & jurisprudence
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - *Jehovah's Witnesses
MH  - Male
MH  - Minors/*legislation & jurisprudence
MH  - Patient Rights/ethics/*legislation & jurisprudence
MH  - *Personal Autonomy
MH  - Physicians/ethics/*legislation & jurisprudence
MH  - Religion and Medicine
MH  - *Splenectomy
MH  - Treatment Outcome
MH  - Treatment Refusal/ethics/*legislation & jurisprudence
EDAT- 2012/02/04 06:00
MHDA- 2012/03/03 06:00
CRDT- 2012/02/04 06:00
PHST- 2012/02/04 06:00 [entrez]
PHST- 2012/02/04 06:00 [pubmed]
PHST- 2012/03/03 06:00 [medline]
AID - 10.1080/00015458.2011.11680771 [doi]
PST - ppublish
SO  - Acta Chir Belg. 2011 Nov-Dec;111(6):355-9. doi: 10.1080/00015458.2011.11680771.


PMID- 22299294
OWN - NLM
STAT- MEDLINE
DCOM- 20120222
LR  - 20191112
IS  - 0350-199X (Linking)
VI  - 65
IP  - 6
DP  - 2011
TI  - Attitude of the Macedonian intensivists regarding withdrawal of therapy in
      intensive care patients: curriculum for policy development.
PG  - 339-42
AB  - UNLABELLED: Ethical confusion regarding withdraw of therapy led to the aim of the
      study in which the knowledge and attitude of the Macedonian Intensive Care Unit
      (ICU) doctors and their impact on decision making process were assessed. METHODS:
      Knowledge, Attitude and Practice (KAP) study has been conducted on a national
      sample of 217 ICU doctors (response rate 83.87%), applying restructured EURELD
      2002 questionnaire as study instrument. CHI-square test was used for cross
      tabulations. RESULTS: 103 responders were females and 79 males with mean age 40, 
      2 years +/- 3 y. Significant percent of the doctors didn't know what is withdraw 
      of therapy, chi-square 34.47 (p < 0.0001) and for most there was no difference
      between withdraw of therapy and euthanasia, chi-square 41.482 (p < 0.0001). Most 
      of doctors didn't have any formal training (67%) and didn't know whether they had
      experience with withdraw or withhold. Similarly to other countries, for
      significantly higher percentage of the Macedonian intensivists patient's wishes
      and patient autonomy have to be main criteria for decision. Significantly higher 
      group of doctors (p < 0.0001) would prefer to leave their own advanced
      directives. CONCLUSIONS: Legal principles in end of life care must be established
      in the country. Courts should have drawn a distinction between intentionally
      causing a patient's death (euthanasia) and allowing a patient to die as a result 
      of the withdrawal of life support treatment. There is a need of additional
      improvement of postgraduate curriculum and continuous professional development of
      ICU doctors working with end-of-life patients.
FAU - Shosholcheva, Mirjana
AU  - Shosholcheva M
AD  - University Clinic of Surgery "St. Naum Ohridski", Skopje, Macedonia.
      sosolceva@hotmail.com
FAU - Gjorgjev, Dragan
AU  - Gjorgjev D
FAU - Tozija, Fimka
AU  - Tozija F
LA  - eng
PT  - Journal Article
PL  - Bosnia and Herzegovina
TA  - Med Arh
JT  - Medicinski arhiv
JID - 0400722
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Data Collection
MH  - Euthanasia, Passive/*psychology
MH  - Female
MH  - Humans
MH  - *Intensive Care Units
MH  - Male
MH  - Medical Staff, Hospital/*psychology
MH  - Montenegro
EDAT- 2012/02/04 06:00
MHDA- 2012/02/23 06:00
CRDT- 2012/02/04 06:00
PHST- 2012/02/04 06:00 [entrez]
PHST- 2012/02/04 06:00 [pubmed]
PHST- 2012/02/23 06:00 [medline]
AID - 10.5455/medarh.2011.65.339-342 [doi]
PST - ppublish
SO  - Med Arh. 2011;65(6):339-42. doi: 10.5455/medarh.2011.65.339-342.


PMID- 22296397
OWN - NLM
STAT- MEDLINE
DCOM- 20120918
LR  - 20181201
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Linking)
VI  - 12
IP  - 9
DP  - 2011
TI  - Healthcare utilization in patients with esophageal cancer in a high risk area in 
      northeast of Iran.
PG  - 2437-42
AB  - INTRODUCTION: Golestan, a province located north of Persian Gulf in northeastern 
      part of Iran is a well known area for high risk of esophageal cancer (EC) in the 
      world. There is no information about healthcare utilization in populations
      residing in the area. This study was conducted to assess utilization of
      healthcare and its associated factors among esophageal cancer patients in this
      region as well as to address ethical implication of this utilization. METHODS:
      All new cases of EC in Golestan province during year of 2007 were recruited.
      Seven diagnostic and five therapeutic services were used to assess diagnostic
      utilization index (DUI), and therapeutic utilization index (TUI), respectively.
      Multivariate regression analysis was used to assess the relationship between
      variables and DUI or TUI. P-value of less than 0.05 was considered as
      statistically significant. RESULTS: Tow hundred twenty three, patients were
      enrolled with mean (Standard Deviation) age of 64.3 (12.5) years with 57.8% male.
      We observed that occupation (P<0.01), ethnicity (P<0.01) and sex (P=0.03) were
      strongly associated with DUI. Insurance coverage (P<0.01), place of residency
      (P<0.01), and occupation (P=0.01) were associated with TUI. CONCLUSION: We
      concluded that several factors contribute to disparity in healthcare utilization 
      in the studied population.
FAU - Roshandel, Gholamreza
AU  - Roshandel G
AD  - Golestan Research Center of Gastroenterology and Hepatology, Golestan University 
      of Medical Sciences, Gorgan, Iran.
FAU - Majdzadeh, Reza
AU  - Majdzadeh R
FAU - Keshtkar, Abbasali
AU  - Keshtkar A
FAU - Aramesh, Kiarash
AU  - Aramesh K
FAU - Sedaghat, Seyed Mehdi
AU  - Sedaghat SM
FAU - Semnani, Shahryar
AU  - Semnani S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
SB  - IM
MH  - Delivery of Health Care/*statistics & numerical data
MH  - Esophageal Neoplasms/*diagnosis/epidemiology/*therapy
MH  - Female
MH  - Humans
MH  - Iran/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Risk
MH  - Risk Factors
EDAT- 2012/02/03 06:00
MHDA- 2012/09/19 06:00
CRDT- 2012/02/03 06:00
PHST- 2012/02/03 06:00 [entrez]
PHST- 2012/02/03 06:00 [pubmed]
PHST- 2012/09/19 06:00 [medline]
PST - ppublish
SO  - Asian Pac J Cancer Prev. 2011;12(9):2437-42.


PMID- 22294868
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1918-1485 (Electronic)
IS  - 1205-7088 (Linking)
VI  - 16
IP  - 2
DP  - 2011 Feb
TI  - Chest compressions and epinephrine during resuscitation of infants born at the
      border of viability: Yes, no or maybe?
PG  - 87-90
AB  - Neonatology, in large part due to its population of babies born at the edge of
      viability, is rife with bioethical issues. This unique population is at high risk
      of mortality and considerable neurodevelopmental morbidity. One contentious,
      ongoing debate concerns whether these extremely low birth weight infants born at 
      the border of viability should, if required by the Neonatal Resuscitation Program
      guidelines, receive chest compressions and epinephrine as part of their delivery 
      room resuscitation. The present article, through a case presentation and
      discussion based on the ethical framework of principlism, provides readers with a
      thoughtful approach to the controversial issue of the provision of chest
      compressions and epinephrine as part of resuscitation for extremely low birth
      weight infants born at the border of viability.
FAU - Moore, Gregory P
AU  - Moore GP
AD  - Department of Pediatrics, Division of Neonatology, Children's Hospital of Eastern
      Ontario;
FAU - Daboval, Thierry
AU  - Daboval T
FAU - Coughlin, Kevin W
AU  - Coughlin KW
LA  - eng
PT  - Journal Article
PL  - England
TA  - Paediatr Child Health
JT  - Paediatrics & child health
JID - 9815960
PMC - PMC3043040
OTO - NOTNLM
OT  - Bioethics
OT  - Cardiopulmonary
OT  - Epinephrine
OT  - Extremely low birth weight
OT  - Infant
OT  - Resuscitation
EDAT- 2012/02/02 06:00
MHDA- 2012/02/02 06:01
CRDT- 2012/02/02 06:00
PHST- 2010/10/22 00:00 [accepted]
PHST- 2012/02/02 06:00 [entrez]
PHST- 2012/02/02 06:00 [pubmed]
PHST- 2012/02/02 06:01 [medline]
AID - 10.1093/pch/16.2.87 [doi]
PST - ppublish
SO  - Paediatr Child Health. 2011 Feb;16(2):87-90. doi: 10.1093/pch/16.2.87.


PMID- 22294866
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1918-1485 (Electronic)
IS  - 1205-7088 (Linking)
VI  - 16
IP  - 2
DP  - 2011 Feb
TI  - Long-distance air transport of an infant weighing less than 500 g: Is it in the
      patient's best interest?
PG  - 79-81
AB  - When a preterm infant is delivered in a region where resources are limited,
      long-distance air transport may be required. However, such transport is a
      significant stressor on an extremely fragile patient, and the neonate's best
      interest must be evaluated. The current article presents the case of the smallest
      infant ever reported to have been transported by air, over more than 2300 km, and
      reflects on clinical and ethical challenges. Is a fragile 450 g baby born in a
      developing country better off spending the first week of his/her life where
      he/she was born, or risking a difficult transport to where he/she could have
      optimal care? What if this baby had already suffered a significant
      intraventricular hemorrhage? What if we were transporting the baby to provide
      palliative care 'at home'? These questions are discussed to illustrate the
      complexity of the decision-making process, and to facilitate a debate on
      transport of such fragile patients.
FAU - Karam, Oliver
AU  - Karam O
AD  - Pediatric Intensive Care Unit;
FAU - Roy, Michel
AU  - Roy M
FAU - Barrington, Keith
AU  - Barrington K
FAU - Janvier, Annie
AU  - Janvier A
LA  - eng
PT  - Case Reports
PL  - England
TA  - Paediatr Child Health
JT  - Paediatrics & child health
JID - 9815960
PMC - PMC3043038
OTO - NOTNLM
OT  - Ethics
OT  - Infant
OT  - Patient transfer
OT  - Premature
EDAT- 2012/02/02 06:00
MHDA- 2012/02/02 06:01
CRDT- 2012/02/02 06:00
PHST- 2010/01/14 00:00 [accepted]
PHST- 2012/02/02 06:00 [entrez]
PHST- 2012/02/02 06:00 [pubmed]
PHST- 2012/02/02 06:01 [medline]
AID - 10.1093/pch/16.2.79 [doi]
PST - ppublish
SO  - Paediatr Child Health. 2011 Feb;16(2):79-81. doi: 10.1093/pch/16.2.79.


PMID- 22294789
OWN - NLM
STAT- MEDLINE
DCOM- 20120308
LR  - 20211021
IS  - 0008-5286 (Print)
IS  - 0008-5286 (Linking)
VI  - 52
IP  - 8
DP  - 2011 Aug
TI  - An ethicist's commentary on duplicity in pet food marketing.
PG  - 824, 826
FAU - Rollin, Bernard E
AU  - Rollin BE
LA  - eng
LA  - fre
PT  - Journal Article
PL  - Canada
TA  - Can Vet J
JT  - The Canadian veterinary journal = La revue veterinaire canadienne
JID - 0004653
SB  - IM
CIN - Can Vet J. 2011 Nov;52(11):1161. PMID: 22547836
CIN - Can Vet J. 2011 Dec;52(12):1275. PMID: 22654127
CIN - Can Vet J. 2011 Dec;52(12):1275. PMID: 22654128
MH  - Animal Feed/*economics
MH  - Animals
MH  - *Ethics, Professional
MH  - Humans
MH  - Marketing/*ethics
MH  - Veterinary Medicine/*ethics/standards
PMC - PMC3135025
EDAT- 2012/02/02 06:00
MHDA- 2012/03/09 06:00
CRDT- 2012/02/02 06:00
PHST- 2012/02/02 06:00 [entrez]
PHST- 2012/02/02 06:00 [pubmed]
PHST- 2012/03/09 06:00 [medline]
PST - ppublish
SO  - Can Vet J. 2011 Aug;52(8):824, 826.


PMID- 22292648
OWN - NLM
STAT- MEDLINE
DCOM- 20120827
LR  - 20170308
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Linking)
VI  - 12
IP  - 8
DP  - 2011
TI  - Practice towards human papillomavirus vaccines among Malaysian women: a survey of
      a general youth population.
PG  - 2045-9
AB  - OBJECTIVE: This study was performed to determine the practice of HPV vaccine
      among Malaysian women in the general population. METHODOLOGY: A cross-sectional
      study was conducted among 233 women during the Academic Year 2010/2011. Written
      consent was obtained from the participants and written information about the
      study was given enclosed with the questionnaire form, consisting of questions on 
      socio-demographic characteristics, knowledge about HPV and practice of HPV
      vaccination. The protocol was approved by the ethics committee of Management and 
      Science University (MSU). Data were analyzed using Statistical Package for Social
      Sciences (SPSS) version 13. The T-test and ANOVA test were used to explore the
      relation between socio-demographic characteristics and the practice of HPV
      vaccine. RESULTS: The majority of the participants were from the age group 17-30 
      years old, Malay, single and having tertiary education (67.8, 62.7, 62.2, 86.3%; 
      respectively). As for knowledge, the majority of them heard about HPV (82.4%),
      knew that multiple sex partners increase the risk (71.7%). Regarding the practice
      of HPV vaccine among respondents, slightly more than half had been vaccinated
      (51.5%). Regarding the factors that influenced the practice of HPV vaccine among 
      general population; age, marital status and family monthly income were
      significant (p=0.001, p=0.001, p=0.001; respectively). CONCLUSION: Age, marital
      status and income significantly influence the practice of HPV vaccine. Therefore 
      promotion of HPV vaccine and inclusion in the national vaccination program is
      very important for primary prevention of cervical cancer among women.
FAU - Al-Naggar, Redhwan Ahmed
AU  - Al-Naggar RA
AD  - Community Medicine Department, International Medical School, Management and
      Science University, Malaysia. radhwan888@yahoo.com
FAU - Bobryshev, Yuri V
AU  - Bobryshev YV
LA  - eng
PT  - Journal Article
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
RN  - 0 (Papillomavirus Vaccines)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cross-Sectional Studies
MH  - Data Collection
MH  - Educational Status
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Malaysia
MH  - Papillomaviridae/immunology
MH  - Papillomavirus Infections/complications/immunology/prevention &
      control/psychology
MH  - Papillomavirus Vaccines/*administration & dosage
MH  - *Patient Acceptance of Health Care
MH  - Surveys and Questionnaires
MH  - Uterine Cervical Neoplasms/*immunology/*prevention & control/virology
MH  - Vaccination/methods/*psychology
MH  - Young Adult
EDAT- 2012/02/02 06:00
MHDA- 2012/08/28 06:00
CRDT- 2012/02/02 06:00
PHST- 2012/02/02 06:00 [entrez]
PHST- 2012/02/02 06:00 [pubmed]
PHST- 2012/08/28 06:00 [medline]
PST - ppublish
SO  - Asian Pac J Cancer Prev. 2011;12(8):2045-9.


PMID- 22292396
OWN - NLM
STAT- MEDLINE
DCOM- 20120214
LR  - 20151119
IS  - 1001-5302 (Print)
IS  - 1001-5302 (Linking)
VI  - 36
IP  - 20
DP  - 2011 Oct
TI  - [Ethical consideration in several commonly used study design].
PG  - 2901-3
AB  - Any study involving human subjects must undergo ethical review which covers
      scientific soundness and ethical resonance, for which, there are common elements 
      to be considered when doing ethical review of research protocols involving human 
      subjects. However, different study design accrue to different ethical
      considerations. This paper explores the main ethical considerations when
      reviewing study designs such as observational study, case record review; surveys,
      questionnaires and interviews. Ethical consideration well-targeted to study
      design will contribute to the human subjects protection.
FAU - Wang, Xiuqin
AU  - Wang X
AD  - Affiliated Hospital of Nanjing University of Traditional Chinese Medicine,
      Nanjing 210029, China. xiuqinwang@ymail.com
FAU - Xie, Yanming
AU  - Xie Y
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Zhong Yao Za Zhi
JT  - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese
      materia medica
JID - 8913656
SB  - IM
MH  - Confidentiality
MH  - *Ethical Review
MH  - Humans
MH  - Informed Consent
MH  - *Research Design
MH  - Surveys and Questionnaires
EDAT- 2012/02/02 06:00
MHDA- 2012/02/15 06:00
CRDT- 2012/02/02 06:00
PHST- 2012/02/02 06:00 [entrez]
PHST- 2012/02/02 06:00 [pubmed]
PHST- 2012/02/15 06:00 [medline]
PST - ppublish
SO  - Zhongguo Zhong Yao Za Zhi. 2011 Oct;36(20):2901-3.


PMID- 22292344
OWN - NLM
STAT- MEDLINE
DCOM- 20120222
LR  - 20120201
IS  - 0008-7335 (Print)
IS  - 0008-7335 (Linking)
VI  - 150
IP  - 11
DP  - 2011
TI  - [Babyboxes in the Czech Republic--what next?].
PG  - 616-8
AB  - Though from the perspective of history babyboxes are not new phenomenon, their
      present existence, however, brings many problems, either in terms of Pediatry and
      neonatology, or because of their social, ethical and also legislative issues. The
      authors provide an overview of the arguments proponents of babyboxes with their
      critical analysis, then provide arguments against placing babyboxes and then
      summarize the experience with their operation in the Czech Republic. In
      conclusion, authors present a list of recommendations to improve the current bad 
      situation.
FAU - Slany, Jaroslav
AU  - Slany J
AD  - Univerzita T. Bati ve Zline a Detske lekarstvi Mestske nemocnice Ostrava.
      jaroslav.slany@mnof.cz
FAU - Schneiberg, Frantisek
AU  - Schneiberg F
LA  - cze
PT  - English Abstract
PT  - Journal Article
TT  - Babyboxy v Ceske republice--jak dal?
PL  - Czech Republic
TA  - Cas Lek Cesk
JT  - Casopis lekaru ceskych
JID - 0004743
SB  - IM
MH  - *Child, Abandoned/legislation & jurisprudence
MH  - *Child, Unwanted/legislation & jurisprudence
MH  - Czech Republic
MH  - Humans
MH  - Infant
MH  - *Infant Welfare
MH  - Infant, Newborn
EDAT- 2012/02/02 06:00
MHDA- 2012/02/23 06:00
CRDT- 2012/02/02 06:00
PHST- 2012/02/02 06:00 [entrez]
PHST- 2012/02/02 06:00 [pubmed]
PHST- 2012/02/23 06:00 [medline]
PST - ppublish
SO  - Cas Lek Cesk. 2011;150(11):616-8.


PMID- 22292315
OWN - NLM
STAT- MEDLINE
DCOM- 20120301
LR  - 20120201
IS  - 0001-4079 (Print)
IS  - 0001-4079 (Linking)
VI  - 195
IP  - 3
DP  - 2011 Mar
TI  - [Evolution of laryngectomy based on a comparison of two cohorts a century apart: 
      an illustration of the progress, difficulties and conflicts encountered in
      medicine].
PG  - 741-53
AB  - Based on a comparison of two cohorts of patients with laryngeal cancer managed by
      laryngectomy one century apart, and an analysis of original textbooks from the
      end of the nineteenth century, we examine the development of laryngectomy, the
      difficulties encountered in this first therapeutic approach to laryngeal
      carcinoma, and the conflicts it generated. The overall death rate changed little 
      over the course of a century, although the 5-year actuarial survival estimate
      improved from 22.6% in 1888 to 75.1% in 1988 (p < .0001). The causes of death
      also changed (p < .0001), with fewer deaths related to post-operative
      complications and/or local failure (82.7% in 1888, 9% in 1988). The rate of
      suicide deaths fell from 1.8% to 0.04%. In contrast, the percentage of deaths due
      to metachronous second primary tumors and/or intercurrent disease increased from 
      9% in 1888 to 76.7% in 1998. Analysis of actuarial survival rates demonstrated
      that 77.4% of patients died before the 60th post-operative month in 1888, while
      this percentage was only reached 275 months post-operatively a century later. Our
      research also underscores the importance of patient information and medical
      ethics.
FAU - Laccourreye, Ollivier
AU  - Laccourreye O
AD  - Oto-rhino-laryngologie et chirurgie cervico-faciale, Hopital europeen Georges
      Pompidou, 20, rue Leblanc 75015 Paris. ollivier.laccourreye@egp.aphp.fr
FAU - Garcia, Dominique
AU  - Garcia D
FAU - Maldent, Jean-Baptiste
AU  - Maldent JB
FAU - Werner, Alfred
AU  - Werner A
LA  - fre
PT  - Comparative Study
PT  - English Abstract
PT  - Historical Article
PT  - Journal Article
TT  - Histoire des laryngectomies illustree par l'analyse de deux cohortes a un siecle 
      de distance : un reflet du progres, des difficultes et des conflits rencontres en
      medecine.
PL  - Netherlands
TA  - Bull Acad Natl Med
JT  - Bulletin de l'Academie nationale de medecine
JID - 7503383
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cohort Studies
MH  - History, 19th Century
MH  - Humans
MH  - Laryngeal Neoplasms/mortality/*surgery
MH  - *Laryngectomy/history
MH  - Middle Aged
EDAT- 2012/02/02 06:00
MHDA- 2012/03/02 06:00
CRDT- 2012/02/02 06:00
PHST- 2012/02/02 06:00 [entrez]
PHST- 2012/02/02 06:00 [pubmed]
PHST- 2012/03/02 06:00 [medline]
PST - ppublish
SO  - Bull Acad Natl Med. 2011 Mar;195(3):741-53.


PMID- 22291838
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1896-9151 (Electronic)
IS  - 1734-1922 (Linking)
VI  - 7
IP  - 5
DP  - 2011 Oct
TI  - Biobank research and ethics: the problem of informed consent in Polish biobanks.
PG  - 896-901
LID - 10.5114/aoms.2011.25568 [doi]
AB  - INTRODUCTION: The dynamic development of biobanks causes some ethical, social,
      and legal problems. The most discussed problems are obtaining informed consent,
      especially for future research, from minors and from deceased people. The aim of 
      this article is to present the current standards held by Polish biobanks
      concerning obtaining a participant's informed consent in some aspects. MATERIAL
      AND METHODS: Survey was carried out by anonymous questionnaire among 59
      institutions which deal with the collecting and storage of human cells and
      tissues in the year 2008. Twenty four filled-in copies of the questionnaires were
      sent back (return=41%). RESULTS: Almost every institution (92%) obtains written
      consent, but a third of the surveyed institutions (29%) do not obtain consent for
      the future use of the samples. The majority of the respondents (83%) support the 
      idea of using biological materials for research purposes of a donor who died if
      he did not leave any written objection to such practices and 46% of respondents
      stated that biobanks should obtain the consent from the already mature donor who 
      gave their samples as a child. CONCLUSIONS: The practice and rules for obtaining 
      informed consent for the scientific research require improvement. The possibility
      to use the human materials in the future, conditions for getting access to the
      data, the possibility of their withdrawal from the database and using the
      materials and data after the death of the donor should be clearly determined when
      the informed consent to collect the material is obtained.
FAU - Pawlikowski, Jakub
AU  - Pawlikowski J
AD  - Department of Ethics and Human Philosophy, Medical University of Lublin, Poland.
FAU - Sak, Jaroslaw
AU  - Sak J
FAU - Marczewski, Krzysztof
AU  - Marczewski K
LA  - eng
PT  - Journal Article
DEP - 20111108
PL  - Poland
TA  - Arch Med Sci
JT  - Archives of medical science : AMS
JID - 101258257
PMC - PMC3258806
OTO - NOTNLM
OT  - biobanks
OT  - genetic collection
OT  - informed consent
OT  - management
OT  - research ethics
EDAT- 2012/02/01 06:00
MHDA- 2012/02/01 06:01
CRDT- 2012/02/01 06:00
PHST- 2010/10/08 00:00 [received]
PHST- 2010/11/24 00:00 [revised]
PHST- 2010/12/18 00:00 [accepted]
PHST- 2012/02/01 06:00 [entrez]
PHST- 2012/02/01 06:00 [pubmed]
PHST- 2012/02/01 06:01 [medline]
AID - 10.5114/aoms.2011.25568 [doi]
AID - 17627 [pii]
PST - ppublish
SO  - Arch Med Sci. 2011 Oct;7(5):896-901. doi: 10.5114/aoms.2011.25568. Epub 2011 Nov 
      8.


PMID- 22291835
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1896-9151 (Electronic)
IS  - 1734-1922 (Linking)
VI  - 7
IP  - 5
DP  - 2011 Oct
TI  - The role of plain radiography in assessing intussusception with vascular
      compromise in children.
PG  - 877-81
LID - 10.5114/aoms.2011.25565 [doi]
AB  - INTRODUCTION: INTRODUCTION: The diagnostic value of colour Doppler sonography for
      the detection of blood flow in intussusception is questionable. The purpose of
      this study was to evaluate plain radiography in the assessment of vascular
      compromise in children with intussusception. MATERIAL AND METHODS: The hospital
      notes of 1,119 paediatric cases of intussusception who presented between January 
      2007 and February 2008 were retrospectively analysed. Informed consent was given 
      by the parents before the air enema and this study was approved by the hospital
      ethics committee. Overall, the plain abdominal X-rays of 190 cases were assessed 
      independently by two experienced radiologists, and disagreements were settled by 
      discussion. Symptom profiles, operative notes and pathological records were
      compared to plain radiography. SAS V8.1 was used for the analysis. RESULTS: Of
      the 190 patients, 30 cases had vascular compromise on plain films, as shown by
      the "coffee-bean" sign or "banana" sign. There was a paucity of gas in 36 cases, 
      a quadrant-specific gas pattern in 51 cases, and the film showed a mass in 73
      cases. Statistical analysis that compared signs on plain radiography signs and
      symptom onset showed a significant difference. Ninety-five cases were irreducible
      by air enema and required surgical intervention. The location of these
      intussusceptions were ileo-ileal-colic (n = 44), ileo-colic (n = 25), ileo-ileal 
      (n = 14), ileo-caecal (n = 10), and ileo-colic-colic (n = 2). Eleven cases had
      intestinal necrosis and underwent resection of the necrotic bowel. CONCLUSIONS:
      The signs of intussusception on plain radiography were significant during the
      clinical assessment of children with secondary ischaemic bowel. The radiological 
      findings were shown to have a high concordance with pathology in the assessment
      of intussusception.The diagnostic value of colour Doppler sonography for the
      detection of blood flow in intussusception is questionable. The purpose of this
      study was to evaluate plain radiography in the assessment of vascular compromise 
      in children with intussusception.
FAU - Guo, Wan-Liang
AU  - Guo WL
AD  - Children's Hospital of Soochow University, China.
FAU - Wang, Jian
AU  - Wang J
FAU - Zhou, Min
AU  - Zhou M
FAU - Sheng, Mao
AU  - Sheng M
FAU - Fang, Lin
AU  - Fang L
LA  - eng
PT  - Journal Article
DEP - 20111108
PL  - Poland
TA  - Arch Med Sci
JT  - Archives of medical science : AMS
JID - 101258257
PMC - PMC3258819
OTO - NOTNLM
OT  - intussusception
OT  - paediatric
OT  - plain radiography
OT  - vascular compromise
EDAT- 2012/02/01 06:00
MHDA- 2012/02/01 06:01
CRDT- 2012/02/01 06:00
PHST- 2011/01/17 00:00 [received]
PHST- 2011/03/21 00:00 [revised]
PHST- 2011/04/14 00:00 [accepted]
PHST- 2012/02/01 06:00 [entrez]
PHST- 2012/02/01 06:00 [pubmed]
PHST- 2012/02/01 06:01 [medline]
AID - 10.5114/aoms.2011.25565 [doi]
AID - 17624 [pii]
PST - ppublish
SO  - Arch Med Sci. 2011 Oct;7(5):877-81. doi: 10.5114/aoms.2011.25565. Epub 2011 Nov
      8.


PMID- 22288354
OWN - NLM
STAT- MEDLINE
DCOM- 20120326
LR  - 20151119
IS  - 0035-2640 (Print)
IS  - 0035-2640 (Linking)
VI  - 61
IP  - 10
DP  - 2011 Dec
TI  - [Death certification and general practitioners: opinion about propositions of
      improvement. Qualitative survey conducted among 14 general practitioners in the
      Loire].
PG  - 1401-10
AB  - Death certificates are one of the sources of national mortality statistics and
      allow for an evaluation of public health. General practitioners regularly certify
      deaths but studies revealed that they had difficulties in doing it. Propositions 
      were made to improve death certification. The objective of our study was to know 
      family physicians opinion about death certification and about those propositions.
      A qualitative survey was conducted through the analysis of 14 general
      practitioners' interviews. Our study confirmed that family physicians had
      difficulties completing death certificates. It also revealed that some
      propositions were rejected: to go rapidly to the deceased (with a few
      exceptions), whole and systematic body examination, call of regular doctor,
      notification of violent or suspect deaths according to official texts. The
      reasons were practical, technical, ethical and personal, or related to an
      obviously natural death (especially for elderly people). Majority of general
      practitioners rejected electronic death certification because they found it
      unpractical. Other propositions were approved: a reminder, written on the death
      certificate, of all situations that need to be referred to a coroner,
      intervention of forensic pathologists for some complex cases. In our study,
      family physicians seem to refuse to investigate patients' death. Therefore,
      better collaboration between forensic pathologists and general practitioners is
      of prime importance: it could be organized through easier access to specialists
      when necessary or through an informative booklet, as suggested by some doctors in
      our study. The validity of these propositions needs to be confirmed.
FAU - Vial-Reyt, Karine
AU  - Vial-Reyt K
AD  - Service universitaire de medecine generale, faculte Jacques-Lisfranc, 42100
      Saint-Etienne. kvial4@yahoo.fr
FAU - Vallee, Josette
AU  - Vallee J
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Certification de deces et medecins generalistes: opinions sur les propositions
      d'amelioration. Enquete qualitative realisee aupres de 14 medecins generalistes
      de la Loire.
PL  - France
TA  - Rev Prat
JT  - La Revue du praticien
JID - 0404334
SB  - IM
MH  - Adult
MH  - *Death Certificates
MH  - Female
MH  - France
MH  - General Practice/*standards
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Practice Patterns, Physicians'
MH  - Quality Control
EDAT- 2012/02/01 06:00
MHDA- 2012/03/27 06:00
CRDT- 2012/02/01 06:00
PHST- 2012/02/01 06:00 [entrez]
PHST- 2012/02/01 06:00 [pubmed]
PHST- 2012/03/27 06:00 [medline]
PST - ppublish
SO  - Rev Prat. 2011 Dec;61(10):1401-10.


PMID- 22288257
OWN - NLM
STAT- MEDLINE
DCOM- 20120301
LR  - 20120131
IS  - 1259-4792 (Print)
IS  - 1259-4792 (Linking)
IP  - 263
DP  - 2011 Nov-Dec
TI  - [Ethical issues involved in communicating to a parent of a child's disability].
PG  - 18-9
AB  - Ethics are an ever-present concern in medicine, and never more so than when it
      comes to announcing a child's disability. The healthcare professional must adopt 
      an appropriate and respectful attitude in order to ensure that information that
      will change several lives is properly understood.
FAU - de Broca, Alain
AU  - de Broca A
AD  - deBroca.Alain@chu-amiens.fr
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Les enjeux ethiques lies a l'annonce d'un handicap chez l'enfant.
PL  - France
TA  - Soins Pediatr Pueric
JT  - Soins. Pediatrie, puericulture
JID - 9604503
MH  - Child
MH  - *Communication
MH  - Developmental Disabilities/*diagnosis
MH  - *Ethics, Medical
MH  - Humans
MH  - Parent-Child Relations
MH  - Parents/*psychology
MH  - Physician-Patient Relations
EDAT- 2012/02/01 06:00
MHDA- 2012/03/02 06:00
CRDT- 2012/02/01 06:00
PHST- 2012/02/01 06:00 [entrez]
PHST- 2012/02/01 06:00 [pubmed]
PHST- 2012/03/02 06:00 [medline]
PST - ppublish
SO  - Soins Pediatr Pueric. 2011 Nov-Dec;(263):18-9.


PMID- 24849751
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140523
LR  - 20160511
IS  - 1947-5535 (Print)
IS  - 1947-5543 (Linking)
VI  - 10
IP  - 1
DP  - 2012 Feb
TI  - Pediatric biobanking: a pilot qualitative survey of practices, rules, and
      researcher opinions in ten European countries.
PG  - 29-36
LID - 10.1089/bio.2011.0037 [doi]
AB  - Ethical, legal, and social issues related to the collection, storage, and use of 
      biospecimens and data derived from children raise critical concerns in the
      international debate. So far, a number of studies have considered a variety of
      the individual issues crucial to pediatric biobanking such as decision making,
      privacy protection, minor recontact, and research withdrawal by focusing on
      theoretical or empirical perspectives. Our research attempted to analyze such
      issues in a comprehensive manner by exploring practices, rules, and researcher
      opinions regarding proxy consent, minor assent, specimens and data handling, and 
      return of results as faced in 10 European countries. Because of the lack of
      comparative analyses of these topics, a pilot study was designed. Following a
      qualitative methodology, a questionnaire draft mostly including open-ended
      queries was developed, tested, and sent by e-mail to a selected group of
      researchers dealing with pediatric biobanking (n=57). Returned questionnaires
      (n=31) highlighted that the collection, storage, distribution, and use of
      biospecimens and data from children were widely practiced in the contacted
      laboratories. In most cases, pediatric biobanking was subjected to national or
      local regulations covering adult biobanks (n=26). Informed consent was generally 
      given by parents or legal representatives (n=17). Children's opinions were
      frequently sought and taken into account (n=16). However, minors were usually not
      recontacted at the age of maturity to express their own choices (n=26). Based on 
      the collected data, dedicated recommendations are needed to govern unique ethical
      and regulatory issues surrounding pediatric biobanking.
FAU - Salvaterra, Elena
AU  - Salvaterra E
AD  - 1 Unit of Bioethics, Scientific Institute "E. Medea," Associazione La Nostra,
      Famiglia, via Don L. Monza, Bosisio Parini (LC), Italy .
FAU - Giorda, Roberto
AU  - Giorda R
FAU - Bassi, Maria T
AU  - Bassi MT
FAU - Borgatti, Renato
AU  - Borgatti R
FAU - Knudsen, Lisbeth E
AU  - Knudsen LE
FAU - Martinuzzi, Andrea
AU  - Martinuzzi A
FAU - Nobile, Maria
AU  - Nobile M
FAU - Pozzoli, Uberto
AU  - Pozzoli U
FAU - Ramelli, Gian P
AU  - Ramelli GP
FAU - Reni, Gianl L
AU  - Reni GL
FAU - Rivolta, Damiano
AU  - Rivolta D
FAU - Stazi, Maria A
AU  - Stazi MA
FAU - Strazzer, Sandra
AU  - Strazzer S
FAU - Thijs, Carel
AU  - Thijs C
FAU - Toccaceli, Virgilia
AU  - Toccaceli V
FAU - Trabacca, Antonio
AU  - Trabacca A
FAU - Turconi, Anna C
AU  - Turconi AC
FAU - Zanini, Sergio
AU  - Zanini S
FAU - Zucca, Claudio
AU  - Zucca C
FAU - Bresolin, Nereo
AU  - Bresolin N
FAU - Lenzi On Behalf Of The Pediatric Biobank Elsi Working Group, Leonardo
AU  - Lenzi On Behalf Of The Pediatric Biobank Elsi Working Group L
LA  - eng
PT  - Journal Article
DEP - 20111213
PL  - United States
TA  - Biopreserv Biobank
JT  - Biopreservation and biobanking
JID - 101507284
EDAT- 2012/02/01 00:00
MHDA- 2012/02/01 00:01
CRDT- 2014/05/23 06:00
PHST- 2014/05/23 06:00 [entrez]
PHST- 2012/02/01 00:00 [pubmed]
PHST- 2012/02/01 00:01 [medline]
AID - 10.1089/bio.2011.0037 [doi]
PST - ppublish
SO  - Biopreserv Biobank. 2012 Feb;10(1):29-36. doi: 10.1089/bio.2011.0037. Epub 2011
      Dec 13.


PMID- 22286814
OWN - NLM
STAT- MEDLINE
DCOM- 20120523
LR  - 20181023
IS  - 1213-8118 (Print)
IS  - 1213-8118 (Linking)
VI  - 155
IP  - 3
DP  - 2011 Sep
TI  - Inter-observer reproducibility of 15 tests used for predicting difficult
      intubation.
PG  - 275-81
LID - 10.5507/bp.2011.041 [doi]
AB  - AIM: To determine the inter-observer reproducibility of 15 tests used for
      predicting difficult tracheal intubation (DI). MATERIAL AND METHODS: Following
      local ethics committee approval and informed consent, 101 volunteers were
      examined by two assessors using 15 tests for predicting DI. The two assessors who
      were blinded to the results of the other, examined each volunteer independently. 
      Cohen's kappa (kappa) or first-order agreement coefficient (AC1) were used to
      measure agreement between assessor ratings on a qualitative scale. Agreement
      between two quantitative outcomes was described using the intraclass correlation 
      coefficient (ICC) and Pearson's (PCC) or Spearman's (SCC) correlation
      coefficients. The following interpretation of the coefficients was used: poor (< 
      0.20), fair (0.21-0.40), satisfactory (0.41-0.60), good (0.61-0.80), and
      excellent (0.81-1.00). RESULTS: Respective coefficients of inter-rater agreement 
      and correlation coefficients were determined for the following parameters:
      pathologies associated with DI (kappa=0.662, AC1=0.990), clinical impression
      (kappa=-0.013, AC1=0.969), modified Mallampati test (kappa=0.503, AC1=0.861),
      upper lip bite test (kappa=0.370, AC1=0.897), temporo-mandibular joint movement
      (kappa=0.088, AC1=0.797), max. anteroflexion of C-spine (ICC=0.136, SCC=0.391),
      max. retroflexion of C-spine (ICC=0.020, SCC=0.284), mandibular length
      (ICC=0.301, SCC=0.553), neck circumference (ICC=0.832, SCC=0.928), hyo-mental
      distance (ICC=0.378, SCC=0.472), thyro-mental distance (ICC=-0.002, PCC=0.265),
      sternomental distance (ICC=0.674, PCC=0.815), and finally, inter-incisor gap
      (ICC=0.695, PCC=0.785). Two tests (positive history of DI and retrogenia), were
      excluded from calculation because no positive cases were found. CONCLUSION: Best 
      inter-rater agreement was found for the assessment of neck circumference while
      the highest discrepancies between raters were in goniometrically-measured
      mobility of the C-spine. Many of the pre-operative airway tests had only fair
      inter-observer reproducibility. This may be one reason why models for predicting 
      difficult intubation are not universally reliable.
FAU - Adamus, Milan
AU  - Adamus M
AD  - Department of Anesthesiology and Intensive Care Medicine, University Hospital
      Olomouc, Palacky University Olomouc, Czech Republic. milan.adamus@seznam.cz
FAU - Jor, Ondrej
AU  - Jor O
FAU - Vavreckova, Tereza
AU  - Vavreckova T
FAU - Hrabalek, Lumir
AU  - Hrabalek L
FAU - Zapletalova, Jana
AU  - Zapletalova J
FAU - Gabrhelik, Tomas
AU  - Gabrhelik T
FAU - Tomaskova, Hana
AU  - Tomaskova H
FAU - Janout, Vladimir
AU  - Janout V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Czech Republic
TA  - Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
JT  - Biomedical papers of the Medical Faculty of the University Palacky, Olomouc,
      Czechoslovakia
JID - 101140142
SB  - IM
MH  - Adult
MH  - Anthropometry
MH  - Female
MH  - Humans
MH  - *Intubation, Intratracheal
MH  - Male
MH  - Neck/anatomy & histology
MH  - Observer Variation
MH  - Physical Examination
MH  - Predictive Value of Tests
MH  - Reproducibility of Results
MH  - Risk Factors
MH  - Young Adult
EDAT- 2012/01/31 06:00
MHDA- 2012/05/24 06:00
CRDT- 2012/01/31 06:00
PHST- 2012/01/31 06:00 [entrez]
PHST- 2012/01/31 06:00 [pubmed]
PHST- 2012/05/24 06:00 [medline]
AID - 10.5507/bp.2011.041 [doi]
PST - ppublish
SO  - Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2011 Sep;155(3):275-81. doi:
      10.5507/bp.2011.041.


PMID- 22286812
OWN - NLM
STAT- MEDLINE
DCOM- 20120523
LR  - 20181023
IS  - 1213-8118 (Print)
IS  - 1213-8118 (Linking)
VI  - 155
IP  - 3
DP  - 2011 Sep
TI  - Determination of serum visinin like protein-1 and its potential for the diagnosis
      of brain injury due to the stroke: a pilot study.
PG  - 263-8
LID - 10.5507/bp.2011.049 [doi]
AB  - BACKGROUND: The current diagnosis of stroke relies on clinical examination by a
      physician supplemented by various neuroimaging techniques. A single set or
      multiple sets of blood biomarkers that could be used in acute settings to
      diagnosis stroke, differentiate between stroke types, and ideally predict an
      initial/recurring stroke would be extremely valuable. The diagnosis of stroke is 
      currently hampered by delay due to lack of a suitable tool for rapid, accurate
      and analytically sensitive biomarker - based testing. There is a clear need for
      further assay development and clinical validation in this area (acute stroke
      setting) in order to improve patient outcomes and quality of life. Visinin like
      protein 1 (VILIP-1) is a newly discovered CNS-abundant protein which has shown
      promise in experimental studies, for early stroke diagnosis. However, to date
      there is no clinical study that has measured VILIP-1 in sera as a marker of
      stroke. AIM: To develop an assay for the determination of VILIP-1 in human serum,
      and to investigate its clinical relevance as a marker of ischemic stroke. DESIGN 
      AND METHODS: A new sandwich ELISA was developed, introduced and clinically
      tested. Mean spiking recovery was 98%. The mean recovery for dilution linearity
      was 93%. The limit of detection of the assay was 0.01 mcg/l; the intraassay and
      interassay coefficient of variation (CV) were always less than 10%. The study was
      approved by the Ethics Commission of the Hospital Sternberk, Czech Republic. A
      total of 17 healthy individuals (9 men and 8 women, age 64.0 +/- 13.0) and 16
      individuals with ischemic stroke (10 men and 6 women, age 63.0+/-11.5) were
      recruited for our study. The criteria of stroke were proposed by the National
      Czech Standard. All individuals had blood samples drawn, and VILIP-1 analysis and
      CT and/or MRI were performed. Results. VILIP-1 serum level significantly
      differentiated healthy subjects from patients with stroke (P<0.01). All
      individuals with stroke had VILIP-1 serum values higher than > 0.05 mcg/l,
      healthy had values below this value. The diagnostic efficacy of serum VILIP-1 was
      very significant (sensitivity 100%, specificity 100% at 0.093 mcg/l VILIP-1 serum
      values, AUC 1.0 (CI 0.93-1.0, P<0.01), Chi-squared in the frequency table was 33 
      (P<0.01). CONCLUSION: We have introduced a new analytical tool for the study of
      VILIP-1. Our results support the hypothesis that serum VILIP-1 may be associated 
      with ischemic stroke. The ELISA VILIP-1 assay offers a new research tool for the 
      diagnosis and pathophysiology of stroke and other CNS diseases.
FAU - Stejskal, David
AU  - Stejskal D
AD  - Department of Laboratory Medicine and Department of Medicine, Prostejov Hospital,
      Central Moravian Hospital County Inc., Czech Republic. david.stejskal@nemsne.cz
FAU - Sporova, Lenka
AU  - Sporova L
FAU - Svestak, Marek
AU  - Svestak M
FAU - Karpisek, Michal
AU  - Karpisek M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Czech Republic
TA  - Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
JT  - Biomedical papers of the Medical Faculty of the University Palacky, Olomouc,
      Czechoslovakia
JID - 101140142
RN  - 0 (Biomarkers)
RN  - 0 (Neurocalcin)
SB  - IM
MH  - Biomarkers/blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neurocalcin/*blood
MH  - Stroke/blood/*diagnosis
EDAT- 2012/01/31 06:00
MHDA- 2012/05/24 06:00
CRDT- 2012/01/31 06:00
PHST- 2012/01/31 06:00 [entrez]
PHST- 2012/01/31 06:00 [pubmed]
PHST- 2012/05/24 06:00 [medline]
AID - 10.5507/bp.2011.049 [doi]
PST - ppublish
SO  - Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2011 Sep;155(3):263-8. doi: 
      10.5507/bp.2011.049.


PMID- 22286801
OWN - NLM
STAT- MEDLINE
DCOM- 20120405
LR  - 20181201
IS  - 0172-780X (Print)
IS  - 0172-780X (Linking)
VI  - 32
IP  - 6
DP  - 2011
TI  - Therapist and supervisor competencies in cognitive behavioural therapy.
PG  - 781-9
AB  - HYPOTHESIS: For cognitive behavioural therapy, acquisition and maintenance of
      psychotherapeutic and supervisory competencies is crucial. METHODS: The PubMed,
      Web of Science and Scopus databases were searched for articles containing the
      following keywords: cognitive-behavioural therapy, competencies, therapeutic
      relationship, intervention, technique, training, supervision, self-reflection,
      empirically supported, transference, countertransference, scheme of therapy,
      dialectical behaviour therapy. The search was performed by repeating the words in
      different combinations with no language or time limitations. The articles were
      sorted and key articles listed in reference lists were searched. In addition,
      original texts by A.T. Beck, J. Beck, C. Padesky, M. Linehan, R. Leahy, J. Young,
      W. Kuyken and others were used. The resources were confronted with our own
      psychotherapeutic and supervisory experiences and only most relevant information 
      was included in the text. Thus, the article is a review with conclusions
      concerned with competencies in cognitive behavioural therapy. RESULTS: For
      cognitive behavioural therapy, four domains of competencies in psychotherapy are 
      crucial - relationship, case assessment and conceptualization, self-reflection
      and intervention. These may be divided into foundational, specific and
      supervisory. The foundational competencies include recognition of empirical basis
      for a clinical approach, good interpersonal skills, ability to establish and
      maintain the therapeutic relationship, self-reflection, sensitivity to a
      difference and ethical behaviour. The specific competencies involve the skill of 
      case conceptualization in terms of maladaptive beliefs and patterns of behaviour,
      ability to think scientifically and teach this to the patient, structure therapy 
      and sessions, assign and check homework, etc. The supervisor's competencies
      include multiple responsibilities in supporting the supervisee, identification
      and processing of the therapist's problems with the patient, continuous
      development, increasing the supervisee's self-reflection, serving as an example
      and being as effective as possible in the role of a clinical instructor.
      CONCLUSION: Both the literature and our own experiences underline the importance 
      of competencies in cognitive behavioural therapy and supervision.
FAU - Prasko, Jan
AU  - Prasko J
AD  - Department of Psychiatry, Faculty of Medicine and Dentistry, Palacky University
      Olomouc, and University Hospital Olomouc, Czech Republic. prasko@fnol.cz
FAU - Vyskocilova, Jana
AU  - Vyskocilova J
FAU - Mozny, Petr
AU  - Mozny P
FAU - Novotny, Miroslav
AU  - Novotny M
FAU - Slepecky, Milos
AU  - Slepecky M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Sweden
TA  - Neuro Endocrinol Lett
JT  - Neuro endocrinology letters
JID - 8008373
SB  - IM
MH  - Cognitive Behavioral Therapy/*education/methods/*standards
MH  - Health Personnel/*education/*standards
MH  - Humans
MH  - Psychotherapy/*education
MH  - Workforce
EDAT- 2012/01/31 06:00
MHDA- 2012/04/06 06:00
CRDT- 2012/01/31 06:00
PHST- 2011/08/14 00:00 [received]
PHST- 2011/09/19 00:00 [accepted]
PHST- 2012/01/31 06:00 [entrez]
PHST- 2012/01/31 06:00 [pubmed]
PHST- 2012/04/06 06:00 [medline]
AID - NEL320611A15 [pii]
PST - ppublish
SO  - Neuro Endocrinol Lett. 2011;32(6):781-9.


PMID- 22286741
OWN - NLM
STAT- MEDLINE
DCOM- 20120821
LR  - 20120130
IS  - 0717-6163 (Electronic)
IS  - 0034-9887 (Linking)
VI  - 139
IP  - 10
DP  - 2011 Oct
TI  - [Bioethics today: Heidegger&#8217;s questions].
PG  - 1378-83
LID - /S0034-98872011001000020 [doi]
AB  - Bioethics was born not only as an aftermath of medical technological advance but 
      also from underlying philosophical conceptions about man, that determine
      scientific research. Analyzing occidental ethics, Heidegger showed that animalism
      was the only human dimension considered and thereby the domain of measurable
      objectiveness. He postulated that the essence of human existence as
      being-in-the-world is ethical and revealed through an original consciousness.
      Unlike moral conscience, original conscience calls to authenticity, to hear his
      constitutive nihilism as a "Being-referred-to-death". The founding ground of
      bioethics may be to listen to this primary being-guilty prior to the derived
      guilts, e.g. faults, deficiencies and shortcomings of specific daily actions.
FAU - Figueroa, Gustavo
AU  - Figueroa G
AD  - Departamento de Psiquiatria, Escuela de Medicina, Universidad de Valparaiso,
      Santiago, Chile. gfigueroacave@gmail.com
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - La bioetica actual: las interrogantes de Heidegger.
DEP - 20120103
PL  - Chile
TA  - Rev Med Chil
JT  - Revista medica de Chile
JID - 0404312
SB  - IM
MH  - *Bioethical Issues
MH  - *Conscience
MH  - *Ethics, Medical
MH  - Famous Persons
MH  - Germany
MH  - Humans
MH  - *Philosophy
EDAT- 2012/01/31 06:00
MHDA- 2012/08/22 06:00
CRDT- 2012/01/31 06:00
PHST- 2012/01/31 06:00 [entrez]
PHST- 2012/01/31 06:00 [pubmed]
PHST- 2012/08/22 06:00 [medline]
AID - S0034-98872011001000020 [pii]
AID - /S0034-98872011001000020 [doi]
PST - ppublish
SO  - Rev Med Chil. 2011 Oct;139(10):1378-83. doi: /S0034-98872011001000020. Epub 2012 
      Jan 3.


PMID- 22282718
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1875-6921 (Print)
IS  - 1875-6913 (Linking)
VI  - 9
IP  - 2
DP  - 2011 Jun 1
TI  - Ethical and Policy Considerations in the Application of Pharmacogenomic Testing
      for Tardive Dyskinesia: Case Study of the Dopamine D3 Receptor.
PG  - 94-101
AB  - Tardive dyskinesia (TD) is a serious adverse effect often associated with the
      first generation antipsychotic medications used in the management of mental
      health disorders such as schizophrenia. Pharmacogenomics is the study of human
      genomic variation in relation to individual and population variability in
      medication response and side effects. Neuropsychiatry is one of the clinical
      domains in which pharmacogenomic approaches have been extensively studied. In the
      late 1990s, the Glycine9 (Gly9) allele of the Serine-9-Glycine (Ser9Gly)
      polymorphism in dopamine D3 receptor gene (DRD3) was found to be associated with 
      both a liability to, and worsened severity of, TD in schizophrenic patients
      treated with typical antipsychotics. This initial discovery has been subsequently
      replicated and testing for the Ser9Gly polymorphism has now become commercially
      available. The question that currently presents itself is whether its use should 
      be encouraged for patients who may be prescribed a typical or atypical
      antipsychotic medication. However, the translation of this new technology to
      clinical practice presents multiple social, ethical and policy challenges. Though
      pharmacogenomic testing holds much promise in this scenario, many important
      questions remain to be answered before its widespread use can be medically and
      ethically justified. This article highlights the key advances in our
      understanding of the role of human genetic variation in the D3 receptor in
      relation to TD. Then, issues of uncertainty, consent, confidentiality, and access
      are considered with respect to the use of DRD3 polymorphism testing in risk
      stratification for susceptibility to tardive dyskinesia. We propose three
      recommendations that may help bring this technology into the clinic: 1)
      prospective pharmacogenomic studies of DRD3 polymorphism and TD risk should be
      conducted; 2) the design of such studies should be influenced by scientists,
      ethicists and policy makers to protect potentially vulnerable patients; and 3)
      appropriate knowledge transfer to front-line health care workers must take place.
FAU - Shamy, Michel C F
AU  - Shamy MC
AD  - Department of Medicine, Division of Neurology, University of Toronto, Toronto,
      Canada.
FAU - Zai, Clement
AU  - Zai C
FAU - Basile, Vincenzo S
AU  - Basile VS
FAU - Kennedy, James L
AU  - Kennedy JL
FAU - Muller, Daniel J
AU  - Muller DJ
FAU - Masellis, Mario
AU  - Masellis M
LA  - eng
GR  - 89853/Canadian Institutes of Health Research/Canada
GR  - 89853/PHS HHS/United States
PT  - Journal Article
PL  - United Arab Emirates
TA  - Curr Pharmacogenomics Person Med
JT  - Current pharmacogenomics and personalized medicine
JID - 101480601
PMC - PMC3265539
MID - CAMS2028
EDAT- 2012/01/28 06:00
MHDA- 2012/01/28 06:01
CRDT- 2012/01/28 06:00
PHST- 2012/01/28 06:00 [entrez]
PHST- 2012/01/28 06:00 [pubmed]
PHST- 2012/01/28 06:01 [medline]
AID - 10.2174/187569211795508448 [doi]
PST - ppublish
SO  - Curr Pharmacogenomics Person Med. 2011 Jun 1;9(2):94-101. doi:
      10.2174/187569211795508448.


PMID- 22282579
OWN - NLM
STAT- MEDLINE
DCOM- 20120727
LR  - 20211021
IS  - 2616-163X (Electronic)
IS  - 0016-9560 (Linking)
VI  - 45
IP  - 3
DP  - 2011 Sep
TI  - Ethics and electronic health information technology: challenges for
      evidence-based medicine and the physician-patient relationship.
PG  - 115-24
AB  - OBJECTIVES: The National Health Insurance Scheme (NHIS), and the National
      Identification Authority (NIA), pose ethical challenges to the physician-patient 
      relationship due to interoperability. This paper explores (1) the national
      legislation on Electronic Health Information Technology (EHIT), (2) the ethics of
      information technology and public health and (3) the effect on the
      Physician-patient relationship. METHOD: This study consisted of systematic
      literature and internet review of the legislation, information technology, the
      national health insurance program, and the physician-patient relationship.
      RESULT: The result shows that (1) EHIT have eroded a big part of the
      confidentiality between the physician and patient; (2) The encroachment on
      privacy is an inevitable outcome of EHIT; (3) Legislation on privacy, the
      collection, storage and uses of electronic health information is needed and; (4) 
      the nexus between EHIT, NHIS, NHA, Ethics, the physician-patient relationship and
      privacy. CONCLUSION: The study highlights the lack of protection for
      physician-patient relationship as medical practice transitions from the
      conventional to the modern, information technology driven domain.
FAU - Norman, I D
AU  - Norman ID
AD  - Department of Biological, Environmental & Occupational Health Science, School of 
      Public Health, College of Health Sciences, University of Ghana, P. O. Box LG 13, 
      Legon, Accra, Ghana. ishmael_norman@yahoo.com
FAU - Aikins, M K
AU  - Aikins MK
FAU - Binka, F N
AU  - Binka FN
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Ghana
TA  - Ghana Med J
JT  - Ghana medical journal
JID - 0073210
SB  - IM
CIN - Ghana Med J. 2011 Sep;45(3):87-8. PMID: 22282573
MH  - Confidentiality/*ethics/legislation & jurisprudence
MH  - Electronic Health Records/*ethics/legislation & jurisprudence
MH  - Evidence-Based Medicine/ethics
MH  - Focus Groups
MH  - Ghana
MH  - Humans
MH  - Interviews as Topic
MH  - Medical Informatics/*ethics/legislation & jurisprudence
MH  - National Health Programs/ethics/legislation & jurisprudence
MH  - Physician-Patient Relations/*ethics
PMC - PMC3266146
OTO - NOTNLM
OT  - Electronic Health Information
OT  - Legislation
OT  - National Health Insurance Scheme
OT  - National Identification Authority
OT  - Physician-patient Relationship
OT  - Public Health
EDAT- 2012/01/28 06:00
MHDA- 2012/07/28 06:00
CRDT- 2012/01/28 06:00
PHST- 2012/01/28 06:00 [entrez]
PHST- 2012/01/28 06:00 [pubmed]
PHST- 2012/07/28 06:00 [medline]
PST - ppublish
SO  - Ghana Med J. 2011 Sep;45(3):115-24.


PMID- 22282573
OWN - NLM
STAT- MEDLINE
DCOM- 20120727
LR  - 20211021
IS  - 2616-163X (Electronic)
IS  - 0016-9560 (Linking)
VI  - 45
IP  - 3
DP  - 2011 Sep
TI  - Ethics and electronic health information technology.
PG  - 87-8
FAU - Edwin, Ama Kyerewaa
AU  - Edwin AK
LA  - eng
PT  - Editorial
PT  - Comment
PL  - Ghana
TA  - Ghana Med J
JT  - Ghana medical journal
JID - 0073210
SB  - IM
CON - Ghana Med J. 2011 Sep;45(3):115-24. PMID: 22282579
MH  - Confidentiality/*ethics
MH  - Electronic Health Records/*ethics
MH  - Humans
MH  - Medical Informatics/*ethics
MH  - Physician-Patient Relations/*ethics
PMC - PMC3266148
EDAT- 2012/01/28 06:00
MHDA- 2012/07/28 06:00
CRDT- 2012/01/28 06:00
PHST- 2012/01/28 06:00 [entrez]
PHST- 2012/01/28 06:00 [pubmed]
PHST- 2012/07/28 06:00 [medline]
PST - ppublish
SO  - Ghana Med J. 2011 Sep;45(3):87-8.


PMID- 22279862
OWN - NLM
STAT- MEDLINE
DCOM- 20120221
LR  - 20120327
IS  - 1660-9379 (Print)
IS  - 1660-9379 (Linking)
VI  - 7
IP  - 321
DP  - 2011 Dec 14
TI  - [End of life care in intensive care units].
PG  - 2440-3
AB  - In intensive care units, death occurs after a medical decision of treatment
      limitation in a great majority of patients. In this context, taking care of the
      patient and his relatives is ethically, practically and emotionally complex. End 
      of life is a well known factor of conflict, burnout and stress among medical and 
      nursing teams in the ICU. The recommendations described in the following article 
      are expected to clarify the roles and practices of the professionals involved in 
      end of life procedures in the ICU.
FAU - Gardaz, V
AU  - Gardaz V
AD  - Service des soins intensifs, Departement d'anesthesiologie, pharmacologie et
      soins intensifs HUG et Universite de Geneve, 1211 Geneve 14.
      valerie.gardaz@hcuge.ch
FAU - Doll, S
AU  - Doll S
FAU - Ricou, B
AU  - Ricou B
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Accompagnement de fin de vie aux soins intensifs.
PL  - Switzerland
TA  - Rev Med Suisse
JT  - Revue medicale suisse
JID - 101219148
RN  - 0 (Analgesics)
RN  - 0 (Hypnotics and Sedatives)
SB  - IM
MH  - Algorithms
MH  - Analgesics/therapeutic use
MH  - Decision Making/physiology
MH  - Humans
MH  - Hypnotics and Sedatives/therapeutic use
MH  - *Intensive Care Units/ethics/legislation & jurisprudence/trends
MH  - Palliative Care/methods
MH  - Professional-Family Relations
MH  - Resuscitation Orders/ethics/legislation & jurisprudence
MH  - Terminal Care/ethics/legislation & jurisprudence/*methods/trends
MH  - Withholding Treatment/ethics/legislation & jurisprudence
EDAT- 2012/01/28 06:00
MHDA- 2012/02/22 06:00
CRDT- 2012/01/28 06:00
PHST- 2012/01/28 06:00 [entrez]
PHST- 2012/01/28 06:00 [pubmed]
PHST- 2012/02/22 06:00 [medline]
PST - ppublish
SO  - Rev Med Suisse. 2011 Dec 14;7(321):2440-3.


PMID- 22279855
OWN - NLM
STAT- MEDLINE
DCOM- 20120308
LR  - 20191210
IS  - 0035-3639 (Print)
IS  - 0035-3639 (Linking)
VI  - 32
IP  - 6
DP  - 2011 Nov-Dec
TI  - [Publicity, ethics and medical deontology].
PG  - 540-3
AB  - Compatibility between publicity and deontology is an old problem. Since a few
      months, TV shows, press interviews or newspapers have aroused interest. Some
      judgements from the European Court and the National Council of the medical Order 
      and lawmakers were expressed. An "inventory of fixtures" seems to be now
      necessary.
FAU - Noterman, J
AU  - Noterman J
AD  - jacques.j.l.noterman@skynet.be
LA  - fre
PT  - Journal Article
PT  - Review
TT  - Publicite, ethique et deontologie medicale.
PL  - Belgium
TA  - Rev Med Brux
JT  - Revue medicale de Bruxelles
JID - 8003474
SB  - IM
MH  - Advertising/*ethics
MH  - *Ethical Theory
MH  - *Ethics, Medical
MH  - Humans
MH  - Information Dissemination/ethics/methods
MH  - Legislation, Medical
MH  - Mass Media/ethics/legislation & jurisprudence
MH  - Patient Education as Topic/ethics/methods
MH  - Surgery, Plastic/ethics/legislation & jurisprudence
EDAT- 2012/01/28 06:00
MHDA- 2012/03/09 06:00
CRDT- 2012/01/28 06:00
PHST- 2012/01/28 06:00 [entrez]
PHST- 2012/01/28 06:00 [pubmed]
PHST- 2012/03/09 06:00 [medline]
PST - ppublish
SO  - Rev Med Brux. 2011 Nov-Dec;32(6):540-3.


PMID- 22279852
OWN - NLM
STAT- MEDLINE
DCOM- 20120308
LR  - 20191210
IS  - 0035-3639 (Print)
IS  - 0035-3639 (Linking)
VI  - 32
IP  - 6
DP  - 2011 Nov-Dec
TI  - [Ethics of organ retrieval after controlled cardiac arrest].
PG  - 523-32
AB  - The article tells the evolution of the terminology concerning non heart beating
      donors during the two last decades and describes summarily the procedure of organ
      retrieval after controlled cardiac arrest. We then consider the various ethical
      problems created by this practice. We discuss in detail therapeutic withdrawal,
      the treatment of the donor during the agonal period, death certification, the
      doctor's conflict of interests, the presence of the family at the time of death, 
      the quality of the organs and organ retrieval after euthanasia.
FAU - Kinnaert, P
AU  - Kinnaert P
AD  - Hopital Erasme.
LA  - fre
PT  - Evaluation Study
PT  - Journal Article
PT  - Review
TT  - Ethique du prelevement d'organes apres arret cardiaque planifie.
PL  - Belgium
TA  - Rev Med Brux
JT  - Revue medicale de Bruxelles
JID - 8003474
SB  - IM
MH  - Belgium
MH  - Cause of Death
MH  - Ethics, Medical
MH  - Euthanasia, Passive/*ethics
MH  - *Heart Arrest/etiology
MH  - Humans
MH  - Respiration, Artificial
MH  - Tissue Donors/ethics
MH  - Tissue and Organ Harvesting/*ethics
MH  - Withholding Treatment/ethics
EDAT- 2012/01/28 06:00
MHDA- 2012/03/09 06:00
CRDT- 2012/01/28 06:00
PHST- 2012/01/28 06:00 [entrez]
PHST- 2012/01/28 06:00 [pubmed]
PHST- 2012/03/09 06:00 [medline]
PST - ppublish
SO  - Rev Med Brux. 2011 Nov-Dec;32(6):523-32.


PMID- 22279847
OWN - NLM
STAT- MEDLINE
DCOM- 20120228
LR  - 20120127
IS  - 1497-3715 (Print)
IS  - 1497-3715 (Linking)
VI  - 22
IP  - 4
DP  - 2011 Winter
TI  - Conversations about challenging end-of-life cases: ethics debriefing in the
      medical surgical intensive care unit.
PG  - 26-30
AB  - Clinicians frequently encounter and grapple with complex ethical issues and
      perplexing moral dilemmas in critical care settings. Intensive care unit (ICU)
      clinicians often experience moral distress in situations in which the ethically
      right course of action is intuitively known, but cannot be acted on. Most
      challenging cases pertain to end-of-life issues. Researchers have shown that
      moral distress and moral residue are common among critical care nurses. It is,
      therefore, essential that all ICU clinicians (and nurses, in particular) have an 
      ongoing opportunity to work safely through these ethical dilemmas and conflicts. 
      In this article, we describe the medical surgical intensive care unit (MSICU)
      experience with its monthly ethics initiative and explore the next steps to
      enhance its use through maximizing attendance and value to MSICU clinicians. To
      optimize attendance of staff a small group discussion among critical care
      clinicians (n = 8) was conducted asking about their perceptions of the debriefing
      sessions and their suggestions on how to promote their use. Process changes were 
      implemented based on the group's suggestions. The process changes resulted in
      increased awareness of the benefits, increased frequency of sessions and
      demonstrated utility. Lessons learned from the MSICU experience will inform the
      development of education curricula to help critical care nurses with challenging 
      end-of-life situations.
FAU - Santiago, Cecilia
AU  - Santiago C
AD  - Critical Care Department, St. Michael's Hospital, Toronto, Ontario.
      santiagoc@smh.ca
FAU - Abdool, Steve
AU  - Abdool S
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Dynamics
JT  - Dynamics (Pembroke, Ont.)
JID - 100955578
MH  - Aged, 80 and over
MH  - Attitude to Death
MH  - Canada
MH  - *Crisis Intervention
MH  - Female
MH  - Humans
MH  - Intensive Care Units
MH  - Life Support Care/ethics
MH  - Nursing Staff/ethics/*psychology
MH  - Professional-Family Relations/ethics
MH  - Stress, Psychological/*prevention & control
MH  - Terminal Care/*ethics
EDAT- 2012/01/28 06:00
MHDA- 2012/03/01 06:00
CRDT- 2012/01/28 06:00
PHST- 2012/01/28 06:00 [entrez]
PHST- 2012/01/28 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
PST - ppublish
SO  - Dynamics. 2011 Winter;22(4):26-30.


PMID- 22279487
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1735-7136 (Electronic)
IS  - 1735-1995 (Linking)
VI  - 16
IP  - 8
DP  - 2011 Aug
TI  - Perimortem caesarean section following maternal gunshot wounds.
PG  - 1089-91
AB  - Perimortem caesarean section is an ethically difficult decision for emergency
      medicine resuscitation teams. A 34-years-old woman was attacked by her husband
      with a gunshot. At the time arrival to the emergency room, there was no pulse, no
      spontaneous breath and blood pressure was unobtainable. Although extensive
      advanced cardiopulmonary resuscita-tion was performed for 7 minutes, no cardiac
      activity was regained. During the cardiopulmonary resuscitation efforts, an
      abdominal ultrasonography was performed and revealed a fetal heart rate with
      bradycardia. Low segment caesarean section was performed by the obstetrician in
      the resuscitation room and a female newborn was delivered within less than one
      minute of the skin incision. Decision on terminating the CPR efforts should not
      be made in maternal cardiac arrests older than 28 weeks' gestational age, unless 
      the viability of the fetus had been evaluated.
FAU - Gunevsel, Ozlem
AU  - Gunevsel O
AD  - Associate Professor, Department of Emergency Medicine, School of Medicine,
      Marmara University, squarestanbul, Turkey.
FAU - Yesil, Onur
AU  - Yesil O
FAU - Ozturk, Tuba Cimilli
AU  - Ozturk TC
FAU - Cevik, Sebnem Eren
AU  - Cevik SE
LA  - eng
PT  - Case Reports
PL  - India
TA  - J Res Med Sci
JT  - Journal of research in medical sciences : the official journal of Isfahan
      University of Medical Sciences
JID - 101235599
PMC - PMC3263088
OTO - NOTNLM
OT  - Emergency Department
OT  - Gunshot Wound
OT  - Perimortem Caesarean Section
OT  - Pregnant Cardiac Arrest
EDAT- 2012/01/27 06:00
MHDA- 2012/01/27 06:01
CRDT- 2012/01/27 06:00
PHST- 2011/03/07 00:00 [received]
PHST- 2011/06/23 00:00 [accepted]
PHST- 2012/01/27 06:00 [entrez]
PHST- 2012/01/27 06:00 [pubmed]
PHST- 2012/01/27 06:01 [medline]
PST - ppublish
SO  - J Res Med Sci. 2011 Aug;16(8):1089-91.


PMID- 22279413
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20220316
IS  - 1179-1365 (Electronic)
IS  - 1179-1365 (Linking)
VI  - 3
DP  - 2011
TI  - Is advertising ethical for dentists? An insight into the Indian scenario.
PG  - 93-8
LID - 10.2147/DHPS.S25708 [doi]
AB  - BACKGROUND: The question of whether Indian dentists should advertise their
      services is an important issue with significant ethical and professional
      implications. Individual dentists may feel the need to advertise in order to
      establish or grow a dental practice, but what effect does this have on the
      standing of the profession as a whole? As health care professionals are bound by 
      a code of ethics, should dentists be allowed to advertise? PURPOSE: The purpose
      of this study is to examine the attitudes of Indian dentists to the issue of
      advertising. It also aims to explore whether advertising could have positive
      benefits (to increase the community's awareness of dental health care, encourage 
      better quality dental services, decrease unemployment in the industry, and help
      consumers choose a dentist), or, on the contrary, whether advertising could have 
      a negative impact by undermining the reputation of the industry, in particular
      the definition of dentistry as a medical profession. METHODS: Of 1500 eligible
      participants, 423 dentists (28.2%) participated in the study. The questionnaire, 
      comprising 14 questions, was provided to the respondents. The data was collected 
      and analyzed by applying the "Chi-squared test" of association and the "Z test"
      of difference between two proportions at 5% and 1% levels of significance (ie, P 
      = 0.05 and P = 0.01). RESULTS: A majority of 56.02% of the respondents were in
      favor of dentists advertising their services. The majority of dentists in favor
      of advertising were in the youngest age group (22-30 years, 75.86%). The older
      age groups were more likely to agree and comply with the government ban on
      advertising by dentists. CONCLUSION: While Indian culture and law does not regard
      advertising as ethical, in recent years there has been a change in the attitudes 
      of dental professionals to the issue of advertising.
FAU - Dable, Rajani A
AU  - Dable RA
AD  - Department of Prosthodontics, Sau Mathurabai Bhausaheb Thorat (SMBT) Dental
      College and Hospital, Sangamner, Maharashtra, India.
FAU - Prasanth, Ma
AU  - Prasanth M
FAU - Singh, Shailendra B
AU  - Singh SB
FAU - Nazirkar, Girish S
AU  - Nazirkar GS
LA  - eng
PT  - Journal Article
DEP - 20111216
PL  - New Zealand
TA  - Drug Healthc Patient Saf
JT  - Drug, healthcare and patient safety
JID - 101544775
PMC - PMC3264423
OTO - NOTNLM
OT  - advertising
OT  - attitudes
OT  - dentistry
OT  - ethics
OT  - health care
OT  - law
OT  - marketing
EDAT- 2012/01/27 06:00
MHDA- 2012/01/27 06:01
CRDT- 2012/01/27 06:00
PHST- 2012/01/27 06:00 [entrez]
PHST- 2012/01/27 06:00 [pubmed]
PHST- 2012/01/27 06:01 [medline]
AID - 10.2147/DHPS.S25708 [doi]
AID - dhps-3-093 [pii]
PST - ppublish
SO  - Drug Healthc Patient Saf. 2011;3:93-8. doi: 10.2147/DHPS.S25708. Epub 2011 Dec
      16.


PMID- 22279319
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1998-3824 (Electronic)
IS  - 0970-1591 (Linking)
VI  - 27
IP  - 4
DP  - 2011 Oct
TI  - Sample size matters: A guide for urologists.
PG  - 503-7
LID - 10.4103/0970-1591.91442 [doi]
AB  - Understanding sample size calculation is vitally important for planning and
      conducting clinical research, and critically appraising literature. The purpose
      of this paper is to present basic statistical concepts and tenets of study design
      pertaining to calculation of requisite sample size. This paper also discusses the
      significance of sample size calculation in the context of ethical considerations.
      Scenarios applicable to urology are utilized in presenting concepts.
FAU - Hinh, Peter
AU  - Hinh P
AD  - Division of Urology, University of Texas Medical School at Houston, Houston,
      Texas, USA.
FAU - Canfield, Steven E
AU  - Canfield SE
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Urol
JT  - Indian journal of urology : IJU : journal of the Urological Society of India
JID - 8510441
PMC - PMC3263221
OTO - NOTNLM
OT  - Evidence-based practice
OT  - research
OT  - statistics
EDAT- 2012/01/27 06:00
MHDA- 2012/01/27 06:01
CRDT- 2012/01/27 06:00
PHST- 2012/01/27 06:00 [entrez]
PHST- 2012/01/27 06:00 [pubmed]
PHST- 2012/01/27 06:01 [medline]
AID - 10.4103/0970-1591.91442 [doi]
AID - IJU-27-503 [pii]
PST - ppublish
SO  - Indian J Urol. 2011 Oct;27(4):503-7. doi: 10.4103/0970-1591.91442.


PMID- 22277482
OWN - NLM
STAT- MEDLINE
DCOM- 20120918
LR  - 20190918
IS  - 1882-0654 (Electronic)
IS  - 0009-918X (Linking)
VI  - 51
IP  - 11
DP  - 2011 Nov
TI  - [Cell therapy for brain diseases: perspective and future prospects].
PG  - 1075-7
AB  - iPS cells have opened up a revolutionarily new era for disease researches and
      regenerative medicine. Disese-specific iPS cells have tremendous promise for the 
      understanding of pathogenesis of numerous intractable brain diseases. Cell
      transplantation therapies using somatic stem cells, ES cells and iPS cells are
      also promising, although ethical issues should be cleared and a lot of problems
      should be solved by technical innovations before they go into clinics.
FAU - Takahashi, Ryosuke
AU  - Takahashi R
AD  - Department of Neurology, Kyoto University Graduate School of Medicine.
FAU - Kondo, Takayuki
AU  - Kondo T
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Rinsho Shinkeigaku
JT  - Rinsho shinkeigaku = Clinical neurology
JID - 0417466
SB  - IM
MH  - Animals
MH  - Brain Diseases/*therapy
MH  - Cell Transplantation/*trends
MH  - Forecasting
MH  - Humans
MH  - Induced Pluripotent Stem Cells/transplantation
MH  - Mice
MH  - Stem Cell Transplantation/trends
EDAT- 2012/01/27 06:00
MHDA- 2012/09/19 06:00
CRDT- 2012/01/27 06:00
PHST- 2012/01/27 06:00 [entrez]
PHST- 2012/01/27 06:00 [pubmed]
PHST- 2012/09/19 06:00 [medline]
AID - JST.JSTAGE/clinicalneurol/51.1075 [pii]
AID - 10.5692/clinicalneurol.51.1075 [doi]
PST - ppublish
SO  - Rinsho Shinkeigaku. 2011 Nov;51(11):1075-7. doi: 10.5692/clinicalneurol.51.1075.


PMID- 22277446
OWN - NLM
STAT- MEDLINE
DCOM- 20120918
LR  - 20190918
IS  - 1882-0654 (Electronic)
IS  - 0009-918X (Linking)
VI  - 51
IP  - 11
DP  - 2011 Nov
TI  - [Ethical issues of personal genome research].
PG  - 975
FAU - Kato, Kazuto
AU  - Kato K
AD  - Genome ELSI Unit, Kyoto University.
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Rinsho Shinkeigaku
JT  - Rinsho shinkeigaku = Clinical neurology
JID - 0417466
SB  - IM
MH  - Cytogenetic Analysis/ethics
MH  - *Ethics, Medical
MH  - Genomics/*ethics
MH  - Humans
EDAT- 2012/01/27 06:00
MHDA- 2012/09/19 06:00
CRDT- 2012/01/27 06:00
PHST- 2012/01/27 06:00 [entrez]
PHST- 2012/01/27 06:00 [pubmed]
PHST- 2012/09/19 06:00 [medline]
AID - JST.JSTAGE/clinicalneurol/51.975 [pii]
AID - 10.5692/clinicalneurol.51.975 [doi]
PST - ppublish
SO  - Rinsho Shinkeigaku. 2011 Nov;51(11):975. doi: 10.5692/clinicalneurol.51.975.


PMID- 22277396
OWN - NLM
STAT- MEDLINE
DCOM- 20120918
LR  - 20190918
IS  - 1882-0654 (Electronic)
IS  - 0009-918X (Linking)
VI  - 51
IP  - 11
DP  - 2011 Nov
TI  - [Practical genetic counseling conducted by clinical neurologist].
PG  - 865-7
AB  - With the increasing knowledge of the molecular bases for neurological disorders, 
      neurologists are now often required to administer genetic testing and to present 
      the resulting information effectively in clinical practice. In the neurologic
      clinical setting, genetic testing of affected individuals is usually taken into
      consideration for a correct diagnosis, but is rarely undertaken in healthy
      individuals to determine genetic risks for their life planning. Genetic
      counseling is indispensable for genetic testing because test results may cause
      serious distress for patients and their family members (referred to as "clients" 
      in the counseling session). Genetic counseling is the medical process of
      communication that helps clients understand the nature of the genetic disorder
      and the options open to them in management and family planning. Through the
      counseling process, clients are given both the medical information and
      psychosocial support necessary for their own decision-making. Thus, the aim of
      genetic counseling is to support the client's decision-making process regarding
      genetic testing, and to avoid unfavorable actions after disclosure of test
      results. In the broad sense, genetic counseling is a part of ordinary clinical
      practice for patients with hereditary neurological disorders because neurologic
      clinical practice includes education and psychosocial support for patients. But
      clients seeking predictive genetic testing, which includes complicated ethical
      and psychosocial issues, should be referred to more specialized genetic
      counseling clinics that take a multi-disciplinary approach. The counseling
      process is not a one-way transmission of medical information by neurologists, but
      consists of two-way communication between patients and neurologists. It is
      therefore crucial for neurologists to master communication skills, particularly
      those involving active listening and empathic understanding, in order to conduct 
      effective genetic counseling in clinical practice.
FAU - Yoshida, Kunihiro
AU  - Yoshida K
AD  - Department of Brain Disease Research, Shinshu University School of Medicine.
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Rinsho Shinkeigaku
JT  - Rinsho shinkeigaku = Clinical neurology
JID - 0417466
SB  - IM
MH  - Empathy
MH  - *Genetic Counseling
MH  - Humans
MH  - Nervous System Diseases/*genetics
EDAT- 2012/01/27 06:00
MHDA- 2012/09/19 06:00
CRDT- 2012/01/27 06:00
PHST- 2012/01/27 06:00 [entrez]
PHST- 2012/01/27 06:00 [pubmed]
PHST- 2012/09/19 06:00 [medline]
AID - JST.JSTAGE/clinicalneurol/51.865 [pii]
AID - 10.5692/clinicalneurol.51.865 [doi]
PST - ppublish
SO  - Rinsho Shinkeigaku. 2011 Nov;51(11):865-7. doi: 10.5692/clinicalneurol.51.865.


PMID- 22277384
OWN - NLM
STAT- MEDLINE
DCOM- 20120918
LR  - 20190918
IS  - 1882-0654 (Electronic)
IS  - 0009-918X (Linking)
VI  - 51
IP  - 11
DP  - 2011 Nov
TI  - [Ethical guidelines for clinical studies: overview].
PG  - 830-3
AB  - Clinical research is guided by ethical principles promulgated in several
      statements, principally the Nuremberg Code, the Helsinki Declaration of the World
      Medical Association etc. In Japan, clinical research of medical products,
      principally trial of new pharmaceutical products is regulated by GCP (good
      clinical practice). Other types of clinical research are regulated by some
      ethical guidelines for clinical researches. The result is a regulatory position
      that is a complex combination of legislation and ethical guidelines. In the
      Ethical Guideline for Clinical Studies revised in 2008, clinical research is
      classified into intervention research and observational research. When
      researchers plan clinical research, they must determine the type of clinical
      research and appropriate ethical guideline for the type of clinical research.
      Advances in health informatics and genetic research have produced a new and very 
      rich body of raw material for clinical research in the form of gene banks and
      genome-wide association study etc. The use of human tissue and medical
      information in the course of clinical research raises issues under the ethical
      regulations for research with human subjects.
FAU - Iijima, Yoshihiko
AU  - Iijima Y
AD  - Department of Ethics Review Committee, Nagoya University Graduate School of
      Medicine.
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Rinsho Shinkeigaku
JT  - Rinsho shinkeigaku = Clinical neurology
JID - 0417466
SB  - IM
MH  - Ethical Review
MH  - *Ethics, Research
MH  - Genome, Human
MH  - Guidelines as Topic
MH  - Humans
EDAT- 2012/01/27 06:00
MHDA- 2012/09/19 06:00
CRDT- 2012/01/27 06:00
PHST- 2012/01/27 06:00 [entrez]
PHST- 2012/01/27 06:00 [pubmed]
PHST- 2012/09/19 06:00 [medline]
AID - JST.JSTAGE/clinicalneurol/51.830 [pii]
AID - 10.5692/clinicalneurol.51.830 [doi]
PST - ppublish
SO  - Rinsho Shinkeigaku. 2011 Nov;51(11):830-3. doi: 10.5692/clinicalneurol.51.830.


PMID- 22276463
OWN - NLM
STAT- MEDLINE
DCOM- 20120325
LR  - 20131121
IS  - 0048-7848 (Print)
IS  - 0048-7848 (Linking)
VI  - 115
IP  - 4
DP  - 2011 Oct-Dec
TI  - [Pharmacoepidemiologic investigations about the interactions between oral
      anticoagulants and other drugs in patients with hemostasis disorders].
PG  - 1155-61
AB  - AIM: To evaluate drugs interactions with oral anticoagulants and their clinical
      relevance, in patients from two emergency departments in hospital. MATERIAL AND
      METHODS: Retrospective study, during one year, on patients (between 18 and 85
      year old) with haemostatic disturbances admitted at two emergency departments in 
      ,,Sf. Spiridon" Hospital, Iasi and in Piatra Neamt Public Hospital, consisted in 
      medical records analysis: the diagnostic, therapy recommended. Data were scored
      and statistically analyzed by t test (Windows Excel). The experimental protocol
      was in agreement with recommendations of the "Gr. T. Popa" University Committee
      for Research and Ethical Issues. RESULTS AND CONCLUSIONS: Analysis and
      statistical processing of data shows that during the period of the study, 69
      patients, which received oral anticoagulant therapy associated with different
      other medication belonged to the 60 and 80 years age group. The findings suggests
      the pathology is represented especially by atrial fibrillation and cerebral
      ischemic diseases. The correlation between the therapy consisting in OAC and
      amiodaronum or statines drugs association and International Normalized Ratio
      (INR), revealed a high level of anticoagulation and an increase of hemorragic
      complications.
FAU - Apostoae, F
AU  - Apostoae F
AD  - Universitatii de Medicina si Farmacie "Gr. T. Popa" Iasi.
FAU - Tartau, Liliana
AU  - Tartau L
FAU - Cimpoesu, Diana
AU  - Cimpoesu D
FAU - Lupusoru, Catalina Elena
AU  - Lupusoru CE
LA  - rum
PT  - English Abstract
PT  - Journal Article
PT  - Multicenter Study
TT  - Investigatii farmacoepidemiologice asupra interactiunilor medicamentoase ale
      anticoagulantelor orale la pacienti cu tulburari ale hemostazei.
PL  - Romania
TA  - Rev Med Chir Soc Med Nat Iasi
JT  - Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi
JID - 0413735
RN  - 0 (Anti-Arrhythmia Agents)
RN  - 0 (Anticoagulants)
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
RN  - N3RQ532IUT (Amiodarone)
SB  - IM
MH  - Administration, Oral
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Amiodarone/administration & dosage/*adverse effects
MH  - Anti-Arrhythmia Agents/administration & dosage/*adverse effects
MH  - Anticoagulants/administration & dosage/*adverse effects
MH  - Atrial Fibrillation/drug therapy
MH  - Brain Ischemia/drug therapy
MH  - Dose-Response Relationship, Drug
MH  - Drug Interactions
MH  - Drug Therapy, Combination
MH  - Emergency Service, Hospital
MH  - Female
MH  - Hemorrhage/*chemically induced/*prevention & control
MH  - Hemostasis/drug effects
MH  - Humans
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage/*adverse
      effects
MH  - International Normalized Ratio
MH  - Male
MH  - Middle Aged
MH  - Pharmacoepidemiology/methods
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Romania
MH  - Time Factors
EDAT- 2012/01/27 06:00
MHDA- 2012/03/27 06:00
CRDT- 2012/01/27 06:00
PHST- 2012/01/27 06:00 [entrez]
PHST- 2012/01/27 06:00 [pubmed]
PHST- 2012/03/27 06:00 [medline]
PST - ppublish
SO  - Rev Med Chir Soc Med Nat Iasi. 2011 Oct-Dec;115(4):1155-61.


PMID- 22276086
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1877-6566 (Electronic)
IS  - 1877-6558 (Linking)
VI  - 5
IP  - 1-4
DP  - 2011 Dec
TI  - The use of race, ethnicity and ancestry in human genetic research.
PG  - 47-63
LID - 10.1007/s11568-011-9154-5 [doi]
AB  - Post-Human Genome Project progress has enabled a new wave of population genetic
      research, and intensified controversy over the use of race/ethnicity in this
      work. At the same time, the development of methods for inferring genetic ancestry
      offers more empirical means of assigning group labels. Here, we provide a
      systematic analysis of the use of race/ethnicity and ancestry in current genetic 
      research. We base our analysis on key published recommendations for the use and
      reporting of race/ethnicity which advise that researchers: explain why the
      terms/categories were used and how they were measured, carefully define them, and
      apply them consistently. We studied 170 population genetic research articles from
      high impact journals, published 2008-2009. A comparative perspective was obtained
      by aligning study metrics with similar research from articles published
      2001-2004. Our analysis indicates a marked improvement in compliance with some of
      the recommendations/guidelines for the use of race/ethnicity over time, while
      showing that important shortfalls still remain: no article using 'race',
      'ethnicity' or 'ancestry' defined or discussed the meaning of these concepts in
      context; a third of articles still do not provide a rationale for their use, with
      those using 'ancestry' being the least likely to do so. Further, no article
      discussed potential socio-ethical implications of the reported research. As such,
      there remains a clear imperative for highlighting the importance of consistent
      and comprehensive reporting on human populations to the genetics/genomics
      community globally, to generate explicit guidelines for the uses of ancestry and 
      genetic ancestry, and importantly, to ensure that guidelines are followed.
FAU - Ali-Khan, Sarah E
AU  - Ali-Khan SE
FAU - Krakowski, Tomasz
AU  - Krakowski T
FAU - Tahir, Rabia
AU  - Tahir R
FAU - Daar, Abdallah S
AU  - Daar AS
LA  - eng
PT  - Journal Article
DEP - 20110707
PL  - Netherlands
TA  - Hugo J
JT  - The HUGO journal
JID - 101530565
PMC - PMC3237839
OTO - NOTNLM
OT  - Ancestry
OT  - Ethnicity
OT  - Genetic ancestry inference
OT  - Genetic research
OT  - Race
OT  - Terminology
EDAT- 2012/01/26 06:00
MHDA- 2012/01/26 06:01
CRDT- 2012/01/26 06:00
PHST- 2011/02/04 00:00 [received]
PHST- 2011/04/27 00:00 [revised]
PHST- 2011/06/17 00:00 [accepted]
PHST- 2012/01/26 06:00 [entrez]
PHST- 2012/01/26 06:00 [pubmed]
PHST- 2012/01/26 06:01 [medline]
AID - 10.1007/s11568-011-9154-5 [doi]
AID - 9154 [pii]
PST - ppublish
SO  - Hugo J. 2011 Dec;5(1-4):47-63. doi: 10.1007/s11568-011-9154-5. Epub 2011 Jul 7.


PMID- 22276051
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120906
LR  - 20220316
IS  - 1754-6605 (Electronic)
IS  - 1754-6605 (Linking)
VI  - 5
DP  - 2011
TI  - Managing pregnant women with cancer: personal considerations and a review of the 
      literature.
PG  - 204
LID - 10.3332/ecancer.2011.204 [doi]
AB  - Managing cancer during pregnancy is a very critical clinical situation. It is
      relatively rare but once encountered, it poses several clinical and sometimes
      social and ethical conflicts as well. Generalizing treatment decisions is very
      hard and in our opinion, each case should be discussed in a multidisciplinary
      manner acknowledging patients' opinion as well to reach a proper decision. In
      this review we touch on the available evidence on managing cancer patients
      diagnosed during the course of pregnancy in an attempt to provide some guidance
      for clinicians dealing with such cases.
FAU - Azim, Ha Jr
AU  - Azim H Jr
AD  - Department of Medical Oncology, Jules Bordet Institute, Brussels, Belgium.
FAU - Gentilini, O
AU  - Gentilini O
FAU - Locatelli, M
AU  - Locatelli M
FAU - Ciriello, E
AU  - Ciriello E
FAU - Scarfone, G
AU  - Scarfone G
FAU - Peccatori, Fa
AU  - Peccatori F
LA  - eng
PT  - Journal Article
DEP - 20110214
PL  - England
TA  - Ecancermedicalscience
JT  - Ecancermedicalscience
JID - 101392236
PMC - PMC3223950
EDAT- 2012/01/26 06:00
MHDA- 2012/01/26 06:01
CRDT- 2012/01/26 06:00
PHST- 2010/11/28 00:00 [received]
PHST- 2012/01/26 06:00 [entrez]
PHST- 2012/01/26 06:00 [pubmed]
PHST- 2012/01/26 06:01 [medline]
AID - 10.3332/ecancer.2011.204 [doi]
AID - can-5-204 [pii]
PST - ppublish
SO  - Ecancermedicalscience. 2011;5:204. doi: 10.3332/ecancer.2011.204. Epub 2011 Feb
      14.


PMID- 22275922
OWN - NLM
STAT- MEDLINE
DCOM- 20120522
LR  - 20211021
IS  - 1729-0503 (Electronic)
IS  - 1680-6905 (Linking)
VI  - 11
IP  - 3
DP  - 2011 Sep
TI  - Measured effect of some socio-demographic factors on depression among breast
      cancer patients receiving chemotherapy in Lagos State University Teaching
      Hospital (LASUTH).
PG  - 341-5
AB  - BACKGROUND: Breast cancer is a disease predominantly found amongst women. It is a
      disease which threatens an organ that is intimately associated with a woman's
      self image, sexuality, as well as her reproductive and nurturing capacity. These 
      threats have serious psychological implications for women living with breast
      cancer. OBJECTIVE: To examine the pattern and predictors of depressive symptoms
      among breast cancer patients receiving chemotherapy in the Lagos State University
      Teaching Hospital (LASUTH). METHODS: Ethical approval was obtained for an ongoing
      multi-centre study. The data used in this study are pre-test scores from breast
      cancer patients in the Lagos State University Teaching Hospital. The 21-item
      Becks Depression Inventory II (BDI-II) was administered on 33 purposively sampled
      breast cancer patients who read and signed informed consent forms before taking
      part in the study. RESULTS: Analysis of data using simple percentages showed that
      the 33 participants indicated varying degree of depressive symptoms: 13 (39.4%)
      of the respondents had minimal depression, 12 (36.4%) of them had mild
      depression, 3 (9.1%) had moderate depression, and 5 (15.2%) had severe
      depression. The average BDI-II score yielded 16.09 indicating mild depression.
      Multiple regression analysis results showed that being informed about breast
      cancer, average monthly income, cancer stage and educational level significantly 
      predicted participants' level of depression. CONCLUSION: This study confirmed the
      presence of depressive symptoms in cancer patients in Nigeria. It was recommended
      that intervention programs to help reduce these depressive symptoms be developed.
FAU - Akin-Odanye, E O
AU  - Akin-Odanye EO
AD  - Department of Guidance and Counselling, University of Ibadan, Nigeria.
      toyin_akinodanye@yahoo.co.uk
FAU - Chioma, C Asuzu
AU  - Chioma CA
FAU - Abiodun, O Popoola
AU  - Abiodun OP
LA  - eng
PT  - Journal Article
PL  - Uganda
TA  - Afr Health Sci
JT  - African health sciences
JID - 101149451
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antineoplastic Agents/therapeutic use
MH  - Breast Neoplasms/drug therapy/*psychology
MH  - Depression/*etiology/psychology
MH  - Educational Status
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Nigeria
MH  - Psychiatric Status Rating Scales
MH  - Regression Analysis
MH  - Risk Factors
MH  - Socioeconomic Factors
PMC - PMC3261007
OTO - NOTNLM
OT  - Breast
OT  - cancer
OT  - chemotherapy
OT  - depression
OT  - woman
EDAT- 2012/01/26 06:00
MHDA- 2012/05/23 06:00
CRDT- 2012/01/26 06:00
PHST- 2012/01/26 06:00 [entrez]
PHST- 2012/01/26 06:00 [pubmed]
PHST- 2012/05/23 06:00 [medline]
PST - ppublish
SO  - Afr Health Sci. 2011 Sep;11(3):341-5.


PMID- 22274932
OWN - NLM
STAT- MEDLINE
DCOM- 20120529
LR  - 20120125
IS  - 1439-1651 (Electronic)
IS  - 0948-2393 (Linking)
VI  - 215
IP  - 6
DP  - 2011 Dec
TI  - [Late interruption of pregnancy due to foetal disease: is an inductive method for
      the generation of ethical principles applicable?].
PG  - 230-3
LID - 10.1055/s-0031-1287857 [doi]
AB  - BACKGROUND: The current study investigates if an inductive method for the
      generation of ethical principles can be applied to the crucial moral question if 
      late interruption of pregnancy due to fetal disease is ethically adequate.
      METHODS: This method originates from the US American philosopher John Rawls and
      puts a group of so-called competent moral investigators in the beginning of the
      decision process. These competent moral investigators should be objective,
      tolerant and sensitive. Thus, real cases which lead to an intuitive, unanimous
      and clear decision of the competent moral investigators are analysed for the
      underlying ethical principles. The ethical principles thus detected are then
      applied to more complicated cases which could not be assessed clearly. RESULTS:
      In the current study, the case of foetal trisomy 18 and foetal palate cleft could
      be clearly judged with a yes and a no, respectively, with regard to an approval
      of late interruption of pregnancy. The underlying ethical principle leading to
      these decisions is the utilitaristic principle of minimising harm for mother and 
      fetus. DISCUSSION: We then tried to apply this principle to a case of foetal
      trisomy 21, however, no clear decision for an approval or a disapproval of the
      interruption of pregnancy could be found as it was not possible to assess foetal 
      interests.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Engel, J B
AU  - Engel JB
AD  - Universitats-Frauenklinik, Wurzburg, Germany. Engel_J@klinik.uni-wuerzburg.de
FAU - Honig, A
AU  - Honig A
FAU - Hausler, S F M
AU  - Hausler SF
FAU - Rehn, M
AU  - Rehn M
FAU - Dietl, J
AU  - Dietl J
FAU - Djakovic, A
AU  - Djakovic A
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Spatabbruch von Schwangerschaften bei fetalen Erkrankungen: Fuhrt ein induktives 
      Verfahren der Normgewinnung zu ethischer Klarheit?
DEP - 20120124
PL  - Germany
TA  - Z Geburtshilfe Neonatol
JT  - Zeitschrift fur Geburtshilfe und Neonatologie
JID - 9508901
SB  - IM
MH  - Abortion, Induced/*ethics
MH  - Decision Making/*ethics
MH  - Female
MH  - *Fetal Diseases
MH  - Germany
MH  - Humans
MH  - Obstetrics/*ethics
MH  - Physician-Patient Relations/*ethics
MH  - Pregnancy
EDAT- 2012/01/26 06:00
MHDA- 2012/05/30 06:00
CRDT- 2012/01/26 06:00
PHST- 2012/01/26 06:00 [entrez]
PHST- 2012/01/26 06:00 [pubmed]
PHST- 2012/05/30 06:00 [medline]
AID - 10.1055/s-0031-1287857 [doi]
PST - ppublish
SO  - Z Geburtshilfe Neonatol. 2011 Dec;215(6):230-3. doi: 10.1055/s-0031-1287857. Epub
      2012 Jan 24.


PMID- 22273560
OWN - NLM
STAT- MEDLINE
DCOM- 20120529
LR  - 20191112
IS  - 1910-622X (Print)
IS  - 1910-622X (Linking)
VI  - 24
IP  - 4
DP  - 2011 Jan
TI  - Exploring ethics in practice: creating moral community in healthcare one place at
      a time.
PG  - 78-87
AB  - Examining everyday ethical situations in clinical practice is a vital but often
      overlooked activity for nursing leaders and practitioners, as well as most other 
      healthcare professionals. In this paper, we share how a series of
      practitioner-led Ethics in Practice sessions (EIPs), which originated within a
      busy urban teaching hospital, were adapted and translated, first into home care
      and more recently, into an EIP session for public health nurses. The success of
      EIP sessions rests with their focus on issues that are selected by practitioners.
      The aims of EIPs are to foster ethical leadership within communities of practice,
      create safe places to share concerns, use relevant research evidence and other
      literature to support informed discussion, and generate stories that deepen our
      understanding of the ethical situations we encounter in our work. We hope our
      experience inspires nursing leaders, nursing colleagues and fellow healthcare
      professionals to consider using the EIP approach to build moral community and the
      idea of moral imagination with their clinical colleagues, one place at a time.
FAU - Scott, Sandra L
AU  - Scott SL
AD  - Central Zone, Alberta Health Services. Sandy.Scott@albertahealthservices.ca
FAU - Marck, Patricia
AU  - Marck P
FAU - Barton, Sylvia
AU  - Barton S
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Nurs Leadersh (Tor Ont)
JT  - Nursing leadership (Toronto, Ont.)
JID - 101470760
MH  - *Ethics, Nursing
MH  - Hospitals, Teaching
MH  - Humans
MH  - Leadership
MH  - *Morals
MH  - Practice Patterns, Physicians'/*statistics & numerical data
MH  - Public Health Nursing/*ethics
MH  - Qualitative Research
MH  - *Residence Characteristics
MH  - Time Factors
EDAT- 2012/01/26 06:00
MHDA- 2012/05/30 06:00
CRDT- 2012/01/26 06:00
PHST- 2012/01/26 06:00 [entrez]
PHST- 2012/01/26 06:00 [pubmed]
PHST- 2012/05/30 06:00 [medline]
AID - 10.12927/cjnl.2012.22736 [doi]
PST - ppublish
SO  - Nurs Leadersh (Tor Ont). 2011 Jan;24(4):78-87. doi: 10.12927/cjnl.2012.22736.


PMID- 22273453
OWN - NLM
STAT- MEDLINE
DCOM- 20120531
LR  - 20161020
IS  - 1552-6909 (Electronic)
IS  - 0090-0311 (Linking)
VI  - 40
IP  - 6
DP  - 2011 Nov-Dec
TI  - Applying ethical practice competencies to the prevention and management of
      unintended pregnancy.
PG  - 808-16
LID - 10.1111/j.1552-6909.2011.01307.x [doi]
AB  - Using a case study that incorporates patient, nurse practitioner, and student
      perspectives, we address ethical principles of respect for autonomy, beneficence,
      and fairness; professionals' right of conscience; and a social justice model for 
      the discussion of prevention and management of unintended pregnancy. Through an
      ongoing process of self-reflection and values clarification, nurses can prepare
      for the challenge of applying ethical principles to the reproductive health care 
      of women.
CI  - (c) 2011 AWHONN, the Association of Women's Health, Obsteric and Neonatal Nurses.
FAU - Cappiello, Joyce
AU  - Cappiello J
AD  - Department of Nursing, The University of New Hampshire, Durham, NH 03824, USA.
      joycec@unh.edu
FAU - Beal, Margaret W
AU  - Beal MW
FAU - Gallogly-Hudson, Kim
AU  - Gallogly-Hudson K
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Obstet Gynecol Neonatal Nurs
JT  - Journal of obstetric, gynecologic, and neonatal nursing : JOGNN
JID - 8503123
SB  - IM
MH  - Adult
MH  - Decision Making
MH  - Female
MH  - Gestational Age
MH  - Humans
MH  - Moral Obligations
MH  - Nurse-Patient Relations
MH  - Nursing, Team/*ethics/methods
MH  - Obstetric Nursing/ethics
MH  - Parity
MH  - Patient Advocacy
MH  - *Personal Autonomy
MH  - Practice Patterns, Nurses'/ethics
MH  - Pregnancy
MH  - *Pregnancy, Unplanned
MH  - *Professional Competence
MH  - United States
EDAT- 2012/01/26 06:00
MHDA- 2012/06/01 06:00
CRDT- 2012/01/26 06:00
PHST- 2012/01/26 06:00 [entrez]
PHST- 2012/01/26 06:00 [pubmed]
PHST- 2012/06/01 06:00 [medline]
AID - 10.1111/j.1552-6909.2011.01307.x [doi]
AID - S0884-2175(15)30770-X [pii]
PST - ppublish
SO  - J Obstet Gynecol Neonatal Nurs. 2011 Nov-Dec;40(6):808-16. doi:
      10.1111/j.1552-6909.2011.01307.x.


PMID- 22273450
OWN - NLM
STAT- MEDLINE
DCOM- 20120531
LR  - 20161020
IS  - 1552-6909 (Electronic)
IS  - 0090-0311 (Linking)
VI  - 40
IP  - 6
DP  - 2011 Nov-Dec
TI  - Grand multiparae's evolving experiences of birthing and technology in U.S.
      hospitals.
PG  - 742-52
LID - 10.1111/j.1552-6909.2011.01304.x [doi]
AB  - OBJECTIVE: To explore the nature of birthing in United States (U.S.) hospitals
      from 1973-2007 and to explicate and interpret common, often overlooked, birthing 
      experiences and nursing care. DESIGN: A Heideggerian phenomenological approach
      utilizing in-depth interviews. SETTING: Participants' homes in Washington, Idaho,
      and Oregon. PARTICIPANTS: A purposive sample of grand multiparaes (N = 14).
      METHODS: Data were collected via open conversational interviews of 60-90 minutes 
      recorded on digital media and completion of a demographic and birth attribute
      form. Field notes and interpretive commentary were used as additional data
      sources and were analyzed using an established Heideggerian approach. RESULTS:
      The participants came from diverse religious and ethical backgrounds and
      experienced 116 births (8.29 births per woman, 79% unmedicated), a Cesarean rate 
      of 6%, and a breastfeeding rate of 99% with a mean duration of 12 months. Two
      overarching patterns emerged: pursuing the "'good birth": a safe passage for baby
      and being in-and-out of control: body, technology, others. Each pattern subsumed 
      several overlapping themes. The first pattern revealed that women often desire a 
      good birth in the safety of a hospital by navigating their options prior to and
      during the birth. The second pattern revealed a common, yet often unachievable,
      desire by all of those involved in the process to control birth. CONCLUSION:
      Harmonizing an exchange of ideas in a technologically advanced environment
      prevalent in hospitals today can increase the quality of intrapartum care.
      Encouraging anchored companions and promoting normal physiological birth will
      make hospitals places where women can experience a good birth and feel safe.
CI  - (c) 2011 AWHONN, the Association of Women's Health, Obstetric and Neonatal
      Nurses.
FAU - Fleming, Susan E
AU  - Fleming SE
AD  - Washington StateUniversity College of Nursing, Spokane, WA 99210, USA.
      sefleming@wsu.edu
FAU - Vandermause, Roxanne
AU  - Vandermause R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Obstet Gynecol Neonatal Nurs
JT  - Journal of obstetric, gynecologic, and neonatal nursing : JOGNN
JID - 8503123
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Cross-Sectional Studies
MH  - Cultural Characteristics
MH  - Delivery, Obstetric/methods/*nursing/*psychology
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - Hospitals/statistics & numerical data
MH  - Humans
MH  - Idaho
MH  - Interviews as Topic
MH  - Maternal Behavior/*psychology
MH  - Middle Aged
MH  - Natural Childbirth/methods
MH  - Nurse's Role
MH  - Nurse-Patient Relations
MH  - Obstetric Nursing/methods
MH  - Oregon
MH  - Parity
MH  - Parturition/*psychology
MH  - Pregnancy
MH  - Risk Factors
MH  - Washington
EDAT- 2012/01/26 06:00
MHDA- 2012/06/01 06:00
CRDT- 2012/01/26 06:00
PHST- 2012/01/26 06:00 [entrez]
PHST- 2012/01/26 06:00 [pubmed]
PHST- 2012/06/01 06:00 [medline]
AID - 10.1111/j.1552-6909.2011.01304.x [doi]
AID - S0884-2175(15)30767-X [pii]
PST - ppublish
SO  - J Obstet Gynecol Neonatal Nurs. 2011 Nov-Dec;40(6):742-52. doi:
      10.1111/j.1552-6909.2011.01304.x.


PMID- 22273130
OWN - NLM
STAT- MEDLINE
DCOM- 20121116
LR  - 20140912
IS  - 0256-9574 (Print)
VI  - 102
IP  - 1
DP  - 2011 Dec 14
TI  - Preimplantation diagnosis to create 'saviour siblings': a critical discussion of 
      the current and future legal frameworks in South Africa.
PG  - 21-4
AB  - Pre-implantation genetic diagnosis (PGD) is a technology used in conjunction with
      in vitro fertilisation to screen embryos for genetic conditions prior to
      transfer. It was initially developed to screen mutations for severe,
      irreversible, genetic conditions. Currently, PGD makes it possible to select
      against more than 100 different genetic conditions. It has been proposed as a
      method for creating a tissue-matched child who can in turn serve as a compatible 
      stem cell donor to save a sick sibling in need of a stem cell transplant. The
      advantage of this method is that it provides genetic information before
      implantation of an embryo into the womb, making it possible to ensure that only
      tissue-matched embryos are transferred to the uterus. A couple can therefore
      avoid the difficult choice of either terminating the pregnancy at a later point
      if the fetus is not a match, or extending their family again in the hope that
      their next child will be tissue compatible. Many people have expressed
      disapproval of the use of PGD for this purpose, and it is associated with many
      conflicting interests including religion, ethics as well as legal regulation. In 
      order to manage these issues some jurisdictions have created legal frameworks to 
      regulate the use of this technology. Many of these are modelled on the UK's Human
      Fertilisation and Embryology Authority and its guardian legislation. This paper
      critiques the current and future South African legal framework to establish
      whether it is able to adequately regulate the use of PGD as well as guard against
      misuse of the technology. It concludes that changes are required to the future
      framework in order to ensure that it regulates the circumstances in which PGD may
      occur and that the Minister of Health should act expediently in finalising draft 
      regulations which will regulate PGD in the future.
FAU - Strode, Ann
AU  - Strode A
AD  - University of KwaZulu Natal.
FAU - Soni, Sheetal
AU  - Soni S
LA  - eng
PT  - Journal Article
DEP - 20111214
PL  - South Africa
TA  - S Afr Med J
JT  - South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
JID - 0404520
SB  - IM
MH  - Dissent and Disputes
MH  - Female
MH  - Fertilization in Vitro/*legislation & jurisprudence
MH  - Genetic Diseases, Inborn/therapy
MH  - Government Regulation
MH  - *Hematopoietic Stem Cell Transplantation/ethics/legislation & jurisprudence
MH  - Histocompatibility Testing/ethics
MH  - Humans
MH  - Pregnancy
MH  - *Preimplantation Diagnosis
EDAT- 2012/01/26 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/01/26 06:00
PHST- 2011/04/07 00:00 [received]
PHST- 2011/07/12 00:00 [accepted]
PHST- 2011/07/11 00:00 [revised]
PHST- 2012/01/26 06:00 [entrez]
PHST- 2012/01/26 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
PST - epublish
SO  - S Afr Med J. 2011 Dec 14;102(1):21-4.


PMID- 22272952
OWN - NLM
STAT- MEDLINE
DCOM- 20121029
LR  - 20140912
IS  - 0256-9574 (Print)
VI  - 101
IP  - 11
DP  - 2011 Nov 1
TI  - Medical ethics and the payment of fees before treatment.
PG  - 798-9
AB  - Whether it is ethically acceptable for doctors to require payment of fees before 
      treatment depends on interpretation of the ethical rules of the profession, the
      circumstances of the doctor-patient relationship, the urgency of the patient's
      need for treatment, and whether refusal to treat before payment represents
      abandonment of a patient.
FAU - McQuoid-Mason, David
AU  - McQuoid-Mason D
AD  - Centre for Socio-Legal Studies, University of KwaZulu-Natal, Durban.
      mcquoidm@ukzn.ac.za
LA  - eng
PT  - Journal Article
DEP - 20111101
PL  - South Africa
TA  - S Afr Med J
JT  - South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
JID - 0404520
SB  - IM
MH  - Emergency Treatment
MH  - *Ethics, Medical
MH  - Fees, Medical/*ethics
MH  - Humans
MH  - Physician-Patient Relations/ethics
MH  - Refusal to Treat/ethics
EDAT- 2012/01/26 06:00
MHDA- 2012/10/30 06:00
CRDT- 2012/01/26 06:00
PHST- 2011/08/11 00:00 [received]
PHST- 2011/08/16 00:00 [accepted]
PHST- 2012/01/26 06:00 [entrez]
PHST- 2012/01/26 06:00 [pubmed]
PHST- 2012/10/30 06:00 [medline]
PST - epublish
SO  - S Afr Med J. 2011 Nov 1;101(11):798-9.


PMID- 22272861
OWN - NLM
STAT- MEDLINE
DCOM- 20120405
LR  - 20140912
IS  - 0256-9574 (Print)
VI  - 101
IP  - 10
DP  - 2011 Sep 27
TI  - Success rate of myringoplasty at Groote Schuur Hospital.
PG  - 740
AB  - OBJECTIVES: The aim of this study was to determine the success rate of
      myringoplasty surgery performed at Groote Schuur Hospital and to evaluate some of
      the presumed prognostic factors. DESIGN: The study design was a retrospective
      analytical cohort. Setting. Groote Schuur Hospital (tertiary medical centre),
      Cape Town. Subjects. This study assessed the success rate of 341 myringoplasty
      operations performed by surgeons in the Department of Otolaryngology from January
      2005 to December 2009. OUTCOME MEASURES: An unsuccessful operation was classified
      as a residual perforation seen at the 3-month follow-up visit that remained
      present at all subsequent visits. Presumed prognostic factors such as the rank of
      the surgeon, size of the perforation, location of the perforation, graft used and
      whether it was a revision procedure, were also evaluated. Where possible, the
      audiometric gain following surgery was calculated. RESULTS: The overall success
      rate in terms of an intact tympanic membrane following myringoplasty was 71%. The
      average improvement in pure tone average following myringoplasty was 12.4 dB. In 
      64% of patients, socially acceptable hearing levels were present postoperatively 
      (air-conduction of less than 30 dB). None of the presumed prognostic factors was 
      a statistically significant determinant (p>0.05). CONCLUSION: The success rate
      for myringoplasty (in terms of perforation closure) of 71% at Groote Schuur
      Hospital compares well with that quoted in the literature. There is no ethical
      dilemma from a surgical outcomes perspective of registrars performing
      myringoplasties.
FAU - Becker, Juanita
AU  - Becker J
FAU - Lubbe, Darlene
AU  - Lubbe D
LA  - eng
PT  - Letter
DEP - 20110927
PL  - South Africa
TA  - S Afr Med J
JT  - South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
JID - 0404520
SB  - IM
MH  - Audiometry, Pure-Tone
MH  - Clinical Competence
MH  - Female
MH  - Humans
MH  - Male
MH  - Myringoplasty/*methods
MH  - Prognosis
MH  - Retrospective Studies
MH  - South Africa
MH  - Treatment Outcome
MH  - Tympanic Membrane Perforation/*surgery
EDAT- 2012/01/26 06:00
MHDA- 2012/04/06 06:00
CRDT- 2012/01/26 06:00
PHST- 2011/01/12 00:00 [received]
PHST- 2011/05/16 00:00 [accepted]
PHST- 2012/01/26 06:00 [entrez]
PHST- 2012/01/26 06:00 [pubmed]
PHST- 2012/04/06 06:00 [medline]
PST - epublish
SO  - S Afr Med J. 2011 Sep 27;101(10):740.


PMID- 22271948
OWN - NLM
STAT- MEDLINE
DCOM- 20120522
LR  - 20211021
IS  - 1564-0604 (Electronic)
IS  - 0042-9686 (Linking)
VI  - 89
IP  - 12
DP  - 2011 Dec 1
TI  - Assessing health system interventions: key points when considering the value of
      randomization.
PG  - 907-12
LID - 10.2471/BLT.11.089524 [doi]
AB  - Research is needed to help identify interventions that will improve the capacity 
      or functioning of health systems and thereby contribute to achieving global
      health goals. Well conducted, randomized controlled trials (RCTs), insofar as
      they reduce bias and confounding, provide the strongest evidence for identifying 
      which interventions delivered directly to individuals are safe and effective.
      When ethically feasible, they can also help reduce bias and confounding when
      assessing interventions targeting entire health systems. However, additional
      challenges emerge when research focuses on interventions that target the multiple
      units of organization found within health systems. Hence, one cannot complacently
      assume that randomization can reduce or eliminate bias and confounding to the
      same degree in every instance. While others have articulated arguments in favour 
      of alternative designs, this paper is intended to help people understand why the 
      potential value afforded by RCTs may be threatened. Specifically, it suggests six
      points to be borne in mind when exploring the challenges entailed in designing or
      evaluating RCTs on health system interventions: (i) the number of units available
      for randomization; (ii) the complexity of the organizational unit under study;
      (iii) the complexity of the intervention; (iv) the complexity of the cause-effect
      pathway, (v) contamination; and (vi) outcome heterogeneity. The authors suggest
      that the latter may be informative and that the reasons behind it should be
      explored and not ignored. Based on improved understanding of the value and
      possible limitations of RCTs on health system interventions, the authors show why
      we need broader platforms of research to complement RCTs.
FAU - English, Mike
AU  - English M
AD  - KEMRI/Wellcome Trust Research Programme, Nairobi, Kenya.
      menglish@nairobi.kemri-wellcome.org
FAU - Schellenberg, Joanna
AU  - Schellenberg J
FAU - Todd, Jim
AU  - Todd J
LA  - eng
GR  - 097170/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111006
PL  - Switzerland
TA  - Bull World Health Organ
JT  - Bulletin of the World Health Organization
JID - 7507052
SB  - IM
MH  - *Community Health Planning
MH  - Epidemiologic Methods
MH  - *Global Health
MH  - Goals
MH  - Health Services Accessibility
MH  - Health Services Needs and Demand
MH  - Humans
MH  - Quality Improvement
MH  - *Quality of Health Care
MH  - *Randomized Controlled Trials as Topic
PMC - PMC3260899
EDAT- 2012/01/25 06:00
MHDA- 2012/05/23 06:00
CRDT- 2012/01/25 06:00
PHST- 2011/04/20 00:00 [received]
PHST- 2011/08/03 00:00 [revised]
PHST- 2011/08/04 00:00 [accepted]
PHST- 2012/01/25 06:00 [entrez]
PHST- 2012/01/25 06:00 [pubmed]
PHST- 2012/05/23 06:00 [medline]
AID - 10.2471/BLT.11.089524 [doi]
AID - BLT.11.089524 [pii]
PST - ppublish
SO  - Bull World Health Organ. 2011 Dec 1;89(12):907-12. doi: 10.2471/BLT.11.089524.
      Epub 2011 Oct 6.


PMID- 22271678
OWN - NLM
STAT- MEDLINE
DCOM- 20120515
LR  - 20211021
IS  - 1542-9768 (Electronic)
IS  - 1542-975X (Linking)
VI  - 93
IP  - 4
DP  - 2011 Dec
TI  - Cardiac developmental toxicity.
PG  - 291-7
LID - 10.1002/bdrc.20219 [doi]
AB  - Congenital heart disease (CHD) is a highly prevalent problem with mostly unknown 
      origins. Many cases of CHD likely involve an environmental exposure coupled with 
      genetic susceptibility, but practical and ethical considerations make nongenetic 
      causes of CHD difficult to assess in humans. The development of the heart is
      highly conserved across all vertebrate species, making animal models an excellent
      option for screening potential cardiac teratogens. This review will discuss
      exposures known to cause cardiac defects, stages of heart development that are
      most sensitive to teratogen exposure, benefits and limitations of animal models
      of cardiac development, and future considerations for cardiac developmental
      toxicity research.
CI  - Copyright (c) 2011 Wiley Periodicals, Inc.
FAU - Mahler, Gretchen J
AU  - Mahler GJ
AD  - Department of Bioengineering, Binghamton University, New York 13902, USA.
FAU - Butcher, Jonathan T
AU  - Butcher JT
LA  - eng
GR  - R01 HL110328/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Birth Defects Res C Embryo Today
JT  - Birth defects research. Part C, Embryo today : reviews
JID - 101167665
RN  - 0 (Teratogens)
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - Heart/*drug effects/*embryology
MH  - Heart Defects, Congenital/*etiology
MH  - Humans
MH  - Mice
MH  - Teratogens/*toxicity
PMC - PMC3717573
MID - NIHMS483733
EDAT- 2012/01/25 06:00
MHDA- 2012/05/16 06:00
CRDT- 2012/01/25 06:00
PHST- 2012/01/25 06:00 [entrez]
PHST- 2012/01/25 06:00 [pubmed]
PHST- 2012/05/16 06:00 [medline]
AID - 10.1002/bdrc.20219 [doi]
PST - ppublish
SO  - Birth Defects Res C Embryo Today. 2011 Dec;93(4):291-7. doi: 10.1002/bdrc.20219.


PMID- 22269530
OWN - NLM
STAT- MEDLINE
DCOM- 20120531
LR  - 20191210
IS  - 1879-2057 (Electronic)
IS  - 0001-4575 (Linking)
VI  - 45
DP  - 2012 Mar
TI  - Strategies for dealing with resistance to recommendations from accident
      investigations.
PG  - 455-67
LID - 10.1016/j.aap.2011.08.014 [doi]
AB  - Accident investigation reports usually lead to a set of recommendations for
      change. These recommendations are, however, sometimes resisted for reasons such
      as various aspects of ethics and power. When accident investigators are aware of 
      this, they use several strategies to overcome the resistance. This paper
      describes strategies for dealing with four different types of resistance to
      change. The strategies were derived from qualitative analysis of 25 interviews
      with Swedish accident investigators from seven application domains. The main
      contribution of the paper is a better understanding of effective strategies for
      achieving change associated with accident investigation.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Lundberg, Jonas
AU  - Lundberg J
AD  - Linkoping University, Department of Science and Technology, Campus Norrkoping,
      601 74 Norrkoping, Sweden. Jonas.lundberg@liu.se
FAU - Rollenhagen, Carl
AU  - Rollenhagen C
FAU - Hollnagel, Erik
AU  - Hollnagel E
FAU - Rankin, Amy
AU  - Rankin A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110916
PL  - England
TA  - Accid Anal Prev
JT  - Accident; analysis and prevention
JID - 1254476
SB  - IM
MH  - Accident Prevention/methods/*standards
MH  - Causality
MH  - *Cooperative Behavior
MH  - *Defense Mechanisms
MH  - Feedback
MH  - Humans
MH  - *Organizational Innovation
MH  - Power, Psychological
MH  - Safety/*standards
MH  - Sweden
EDAT- 2012/01/25 06:00
MHDA- 2012/06/01 06:00
CRDT- 2012/01/25 06:00
PHST- 2011/01/16 00:00 [received]
PHST- 2011/08/09 00:00 [revised]
PHST- 2011/08/22 00:00 [accepted]
PHST- 2012/01/25 06:00 [entrez]
PHST- 2012/01/25 06:00 [pubmed]
PHST- 2012/06/01 06:00 [medline]
AID - S0001-4575(11)00234-X [pii]
AID - 10.1016/j.aap.2011.08.014 [doi]
PST - ppublish
SO  - Accid Anal Prev. 2012 Mar;45:455-67. doi: 10.1016/j.aap.2011.08.014. Epub 2011
      Sep 16.


PMID- 22269269
OWN - NLM
STAT- MEDLINE
DCOM- 20120306
LR  - 20120124
IS  - 1558-3171 (Electronic)
IS  - 0039-6109 (Linking)
VI  - 92
IP  - 1
DP  - 2012 Feb
TI  - Open disclosure of adverse events: transparency and safety in health care.
PG  - 163-77
LID - 10.1016/j.suc.2011.11.001 [doi]
AB  - Many patients suffering adverse events in health care turn to the legal system to
      learn what happened to them and to seek compensation. Health care providers have 
      ethical, professional, and legal duties to disclose the harmful effects of care
      to the patient, regardless of how small the risk. The purpose of open disclosure 
      is to explain what happened to the patient and to seek a just outcome for patient
      and provider. This article explores our experience of managing and implementing
      an open disclosure program in an acute and chronic tertiary care facility with
      university affiliation in the Veterans Health Administration.
CI  - Published by Elsevier Inc.
FAU - Eaves-Leanos, Aaliyah
AU  - Eaves-Leanos A
AD  - Lexington VA Medical Center, Lexington, KY, USA.
FAU - Dunn, Edward J
AU  - Dunn EJ
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111227
PL  - United States
TA  - Surg Clin North Am
JT  - The Surgical clinics of North America
JID - 0074243
SB  - IM
MH  - Hospitals, Veterans/ethics/legislation & jurisprudence/*organization &
      administration
MH  - Humans
MH  - Kentucky
MH  - Medical Errors/*adverse effects/ethics/legislation & jurisprudence
MH  - Patient Safety
MH  - Professional-Family Relations/ethics
MH  - Professional-Patient Relations/ethics
MH  - Safety Management/organization & administration
MH  - Truth Disclosure/*ethics
EDAT- 2012/01/25 06:00
MHDA- 2012/03/07 06:00
CRDT- 2012/01/25 06:00
PHST- 2012/01/25 06:00 [entrez]
PHST- 2012/01/25 06:00 [pubmed]
PHST- 2012/03/07 06:00 [medline]
AID - S0039-6109(11)00149-6 [pii]
AID - 10.1016/j.suc.2011.11.001 [doi]
PST - ppublish
SO  - Surg Clin North Am. 2012 Feb;92(1):163-77. doi: 10.1016/j.suc.2011.11.001. Epub
      2011 Dec 27.


PMID- 22268264
OWN - NLM
STAT- MEDLINE
DCOM- 20120209
LR  - 20200923
IS  - 0390-6663 (Print)
IS  - 0390-6663 (Linking)
VI  - 38
IP  - 4
DP  - 2011
TI  - Effect of multiple source vs single source of donor embryos on pregnancy and
      implantation rates per transfer.
PG  - 324-5
AB  - PURPOSE: To evaluate whether using donated embryos from more than one source has 
      a negative impact on pregnancy rates compared to a single source. METHODS:
      Retrospective review of all donor embryo transfers that occurred in our IVF
      center over a 10-year period. Embryos were all from our own patient pool.
      RESULTS: There were no differences in clinical or live delivered pregnancy rates.
      CONCLUSIONS: The willingness to choose multiple sources allows a marked reduction
      in the waiting time for donated embryos which are scarce. This also reduced the
      financial burden for couples who for religious or for ethical reasons cannot
      destroy the embryos and have to pay continuous embryo storage charges.
FAU - Wilson, C
AU  - Wilson C
AD  - The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson
      Medical School at Camden Cooper Hospital/University Medical Center, Department of
      Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, 
      Camden, NJ, USA.
FAU - Check, J H
AU  - Check JH
FAU - Amui, J
AU  - Amui J
FAU - Choe, J K
AU  - Choe JK
FAU - Brasile, D
AU  - Brasile D
LA  - eng
PT  - Journal Article
PL  - Singapore
TA  - Clin Exp Obstet Gynecol
JT  - Clinical and experimental obstetrics & gynecology
JID - 7802110
SB  - IM
MH  - *Embryo Transfer
MH  - Female
MH  - *Fertilization in Vitro
MH  - Humans
MH  - *Oocyte Donation
MH  - Pregnancy
MH  - Pregnancy Outcome
MH  - Retrospective Studies
EDAT- 2012/01/25 06:00
MHDA- 2012/02/10 06:00
CRDT- 2012/01/25 06:00
PHST- 2012/01/25 06:00 [entrez]
PHST- 2012/01/25 06:00 [pubmed]
PHST- 2012/02/10 06:00 [medline]
PST - ppublish
SO  - Clin Exp Obstet Gynecol. 2011;38(4):324-5.


PMID- 22266891
OWN - NLM
STAT- MEDLINE
DCOM- 20120510
LR  - 20120123
IS  - 1098-9021 (Electronic)
IS  - 0271-8235 (Linking)
VI  - 31
IP  - 5
DP  - 2011 Nov
TI  - Genetic testing for neurologic disorders.
PG  - 542-52
LID - 10.1055/s-0031-1299792 [doi]
AB  - New technologies and more research in genetics have revealed an increasing amount
      of genetic data and identified new diseases. In parallel to the wider
      availability of genetic testing, efforts have been made to regulate the use of
      genetic technology and genetic information. The swift pace of developments, not
      surprisingly, may cause uncertainty among those confronted with genetics. The
      authors review the current state of genetic testing with a focus on movement
      disorders. They introduce terminology (inheritance patterns; penetrance; clinical
      and genetic heterogeneity and types of testing, including influences of
      direct-to-consumer testing) and discuss general aspects of genetics, including
      indication for testing, familial implications as well as social, ethical, and in 
      particular legal implications (discrimination acts, insurance aspects, protection
      of data of deceased, etc.). They also cover recent developments with regard to
      new molecular techniques, economic issues, and the difficulties of data
      interpretation.
CI  - (c) Thieme Medical Publishers.
FAU - Schneider, Susanne A
AU  - Schneider SA
AD  - Schilling Section of Clinical and Molecular Neurogenetics, Department of
      Neurology, University of Lubeck, Lubeck, Germany.
      susanne.schneider@neuro.uni-luebeck.de
FAU - Schneider, Uwe H
AU  - Schneider UH
FAU - Klein, Christine
AU  - Klein C
LA  - eng
PT  - Journal Article
DEP - 20120121
PL  - United States
TA  - Semin Neurol
JT  - Seminars in neurology
JID - 8111343
SB  - IM
MH  - Genetic Counseling/economics/ethics/legislation & jurisprudence/methods
MH  - *Genetic Testing/economics/ethics/legislation & jurisprudence/methods
MH  - Humans
MH  - Nervous System Diseases/*genetics
MH  - Penetrance
EDAT- 2012/01/24 06:00
MHDA- 2012/05/11 06:00
CRDT- 2012/01/24 06:00
PHST- 2012/01/24 06:00 [entrez]
PHST- 2012/01/24 06:00 [pubmed]
PHST- 2012/05/11 06:00 [medline]
AID - 10.1055/s-0031-1299792 [doi]
PST - ppublish
SO  - Semin Neurol. 2011 Nov;31(5):542-52. doi: 10.1055/s-0031-1299792. Epub 2012 Jan
      21.


PMID- 22265383
OWN - NLM
STAT- MEDLINE
DCOM- 20120521
LR  - 20120123
IS  - 1873-1465 (Electronic)
IS  - 0031-9406 (Linking)
VI  - 98
IP  - 1
DP  - 2012 Mar
TI  - A process of informed consent for student learning through peer physical
      examination in pelvic floor physiotherapy practice.
PG  - 33-9
LID - 10.1016/j.physio.2011.04.347 [doi]
AB  - Peer physical examination (PPE) is a method of teaching and learning clinical
      skills in which students use fellow students as surrogate patients or models. PPE
      is recognised as useful as an experiential learning method to increase skill
      development for physiotherapy clinical practice. However students may feel
      pressured to participate despite discomfort and embarrassment when practising
      physical examination and treatment skills with their peers. Obtaining students'
      informed consent to participate in PPE is an important process to address these
      disadvantages of PPE. This paper proposes a three stage process for obtaining
      informed consent from postgraduate physiotherapy students learning pelvic floor
      examination and treatment skills. The process is designed to encourage educators 
      to articulate the ethical issues that are relevant in this area of teaching; to
      provide information to students to enable them to understand what is involved and
      to choose to participate, and to offer alternatives to participation through a
      formalised process of informed consent. These steps mirror students' future
      obligations and actions when communicating with their patients.
CI  - Crown Copyright (c) 2011. Published by Elsevier Ltd. All rights reserved.
FAU - Delany, Clare
AU  - Delany C
AD  - Department of Physiotherapy, School of Health Sciences, University of Melbourne, 
      200 Berkely st, Parkville 3010, Australia. c.delany@unimelb.edu.au
FAU - Frawley, Helena
AU  - Frawley H
LA  - eng
PT  - Journal Article
DEP - 20110526
PL  - England
TA  - Physiotherapy
JT  - Physiotherapy
JID - 0401223
SB  - IM
MH  - Clinical Competence
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Pelvic Floor Disorders/*diagnosis
MH  - Physical Examination/*methods
MH  - Physical Therapy Specialty/education/*methods
MH  - *Students, Health Occupations
MH  - Teaching/methods
EDAT- 2012/01/24 06:00
MHDA- 2012/05/23 06:00
CRDT- 2012/01/24 06:00
PHST- 2010/10/15 00:00 [received]
PHST- 2011/04/20 00:00 [accepted]
PHST- 2012/01/24 06:00 [entrez]
PHST- 2012/01/24 06:00 [pubmed]
PHST- 2012/05/23 06:00 [medline]
AID - S0031-9406(11)00414-7 [pii]
AID - 10.1016/j.physio.2011.04.347 [doi]
PST - ppublish
SO  - Physiotherapy. 2012 Mar;98(1):33-9. doi: 10.1016/j.physio.2011.04.347. Epub 2011 
      May 26.


PMID- 22263371
OWN - NLM
STAT- MEDLINE
DCOM- 20120301
LR  - 20120123
IS  - 0002-7979 (Print)
IS  - 0002-7979 (Linking)
VI  - 78
IP  - 3
DP  - 2011 Fall
TI  - Ethics fundamentals.
PG  - 41-6
AB  - Ethics is about studying the right and the good; morality is about acting as one 
      should. Although there are differences among what is legal, charitable,
      professional, ethical, and moral, these desirable characteristics tend to cluster
      and are treasured in dentistry. The traditional approach to professionalism in
      dentistry is based on a theory of biomedical ethics advanced 30 years ago. Known 
      as the principles approach, general ideals such as respect for autonomy,
      nonmaleficence, beneficence, justice, and veracity, are offered as guides. Growth
      in professionalism consists in learning to interpret the application of these
      principles as one's peers do. Moral behavior is conceived as a continuous cycle
      of sensitivity to situations requiring moral response, moral reasoning, the moral
      courage to take action when necessary, and integration of habits of moral
      behavior into one's character. This essay is the first of two papers that provide
      the backbone for the IDEA Project of the College--an online, multiformat,
      interactive "textbook" of ethics for the profession.
FAU - Chambers, David W
AU  - Chambers DW
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Am Coll Dent
JT  - The Journal of the American College of Dentists
JID - 7503057
SB  - IM
MH  - *Ethical Theory
MH  - *Ethics, Dental
MH  - Humans
MH  - Morals
MH  - Social Responsibility
MH  - United States
EDAT- 2012/01/24 06:00
MHDA- 2012/03/02 06:00
CRDT- 2012/01/24 06:00
PHST- 2012/01/24 06:00 [entrez]
PHST- 2012/01/24 06:00 [pubmed]
PHST- 2012/03/02 06:00 [medline]
PST - ppublish
SO  - J Am Coll Dent. 2011 Fall;78(3):41-6.


PMID- 22263370
OWN - NLM
STAT- MEDLINE
DCOM- 20120301
LR  - 20120123
IS  - 0002-7979 (Print)
IS  - 0002-7979 (Linking)
VI  - 78
IP  - 3
DP  - 2011 Fall
TI  - The challenges of oral-based diagnostics in extending the role of dentistry as a 
      health care profession: property rights, privacy, and informed consent.
PG  - 33-40
AB  - Saliva may be a legal and ethical counterpart of other bodily fluids in
      diagnostic testing to blood and urine, with regard to its role in diagnostic
      testing. Two paradigms that have been proposed in the literature to address these
      challenges are reviewed in this paper. The first is centered on ownership and
      property rights to saliva, including financial compensation from commercially
      developed products using saliva. The commodification of saliva as property is
      also discussed. The second paradigm is related to privacy and the potential for
      genetic discrimination, given the unwarranted disclosure of confidential
      information. The management of saliva specimens from dental patients and research
      participants will also require the implementation of innovative approaches to
      obtain informed consent.
FAU - Vernillo, Anthony
AU  - Vernillo A
AD  - Department of Oral & Maxillofacial Pathology, Radiology & Medicine, New York
      University College of Dentistry, USA. chart212@aol.com
FAU - Welie, Jos V M
AU  - Welie JV
FAU - Naidoo, Sudeshni
AU  - Naidoo S
FAU - Malamud, Daniel
AU  - Malamud D
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Coll Dent
JT  - The Journal of the American College of Dentists
JID - 7503057
SB  - IM
MH  - Diagnostic Techniques and Procedures/*ethics
MH  - *Ethics, Dental
MH  - Humans
MH  - *Informed Consent
MH  - Ownership/*ethics
MH  - Patient Rights/*ethics
MH  - *Privacy
MH  - Saliva/*chemistry
EDAT- 2012/01/24 06:00
MHDA- 2012/03/02 06:00
CRDT- 2012/01/24 06:00
PHST- 2012/01/24 06:00 [entrez]
PHST- 2012/01/24 06:00 [pubmed]
PHST- 2012/03/02 06:00 [medline]
PST - ppublish
SO  - J Am Coll Dent. 2011 Fall;78(3):33-40.


PMID- 22263369
OWN - NLM
STAT- MEDLINE
DCOM- 20120301
LR  - 20120123
IS  - 0002-7979 (Print)
IS  - 0002-7979 (Linking)
VI  - 78
IP  - 3
DP  - 2011 Fall
TI  - My life as a dentist and ethicist: an experiment in creative nonfiction.
PG  - 31-2
AB  - In a certain sense, we become the synthesis of our life experiences, and our
      professional identity is woven into a personal life story. A dentist with a PhD
      in Health Services Research and Policy who teaches clinical dentistry and ethics 
      reflects on some of the moments that have combined to make her who she is.
FAU - Quick, K K
AU  - Quick KK
AD  - University of Minnesota, USA. quick003@umn.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Coll Dent
JT  - The Journal of the American College of Dentists
JID - 7503057
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Education, Dental
MH  - Ethics, Dental/*education
MH  - Humans
MH  - Minnesota
MH  - *Professional Practice
EDAT- 2012/01/24 06:00
MHDA- 2012/03/02 06:00
CRDT- 2012/01/24 06:00
PHST- 2012/01/24 06:00 [entrez]
PHST- 2012/01/24 06:00 [pubmed]
PHST- 2012/03/02 06:00 [medline]
PST - ppublish
SO  - J Am Coll Dent. 2011 Fall;78(3):31-2.


PMID- 22263368
OWN - NLM
STAT- MEDLINE
DCOM- 20120301
LR  - 20120123
IS  - 0002-7979 (Print)
IS  - 0002-7979 (Linking)
VI  - 78
IP  - 3
DP  - 2011 Fall
TI  - Combining practice with ethics.
PG  - 29-30
AB  - As a dentist at the Mayo Clinic in Rochester, Minnesota, the author has found it 
      easy and rewarding to combine specialty care in orofacial pain with ethics
      training for complex case management.
FAU - Reid, Kevin I
AU  - Reid KI
AD  - Mayo Clinic, USA. reid.kevin@mayo.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Coll Dent
JT  - The Journal of the American College of Dentists
JID - 7503057
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Ethics, Dental/*education
MH  - Humans
MH  - Minnesota
MH  - *Practice Management, Dental
MH  - *Professional Practice
EDAT- 2012/01/24 06:00
MHDA- 2012/03/02 06:00
CRDT- 2012/01/24 06:00
PHST- 2012/01/24 06:00 [entrez]
PHST- 2012/01/24 06:00 [pubmed]
PHST- 2012/03/02 06:00 [medline]
PST - ppublish
SO  - J Am Coll Dent. 2011 Fall;78(3):29-30.


PMID- 22263366
OWN - NLM
STAT- MEDLINE
DCOM- 20120301
LR  - 20120123
IS  - 0002-7979 (Print)
IS  - 0002-7979 (Linking)
VI  - 78
IP  - 3
DP  - 2011 Fall
TI  - Ethics and the 'seasons of my life' as a dental educator.
PG  - 18-23
AB  - Perhaps the first comprehensive ethics program in American dental schools was
      created in 1990 at the University of Kentucky by then dean David Nash. Nash
      recounts the emergence of his personal and professional interest in ethics using 
      the structure of Daniel Levinson's book The Seasons of a Man's Life. Each season 
      brings tasks of evolving and deepening ethical engagement. Being ethical is
      important; helping others to be so is special. Nash still teaches the course.
FAU - Nash, David A
AU  - Nash DA
AD  - College of Dentistry, University of Kentucky, USA. danash@email.uky.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Coll Dent
JT  - The Journal of the American College of Dentists
JID - 7503057
SB  - IM
MH  - Clinical Competence
MH  - Education, Dental/*organization & administration
MH  - Ethics, Dental/*education
MH  - Humans
MH  - Kentucky
MH  - Mentors
MH  - Philosophy, Dental
MH  - Social Responsibility
EDAT- 2012/01/24 06:00
MHDA- 2012/03/02 06:00
CRDT- 2012/01/24 06:00
PHST- 2012/01/24 06:00 [entrez]
PHST- 2012/01/24 06:00 [pubmed]
PHST- 2012/03/02 06:00 [medline]
PST - ppublish
SO  - J Am Coll Dent. 2011 Fall;78(3):18-23.


PMID- 22263365
OWN - NLM
STAT- MEDLINE
DCOM- 20120301
LR  - 20120123
IS  - 0002-7979 (Print)
IS  - 0002-7979 (Linking)
VI  - 78
IP  - 3
DP  - 2011 Fall
TI  - Ethics is how you respond to life.
PG  - 14-7
AB  - A practicing dentist with a law degree describes how early life and career events
      shaped his view toward ethics in the dental profession. He has combined these
      life lessons, ethical theory, law training, and practice management experience
      into a course for dental students that emphasizes the complex, integrated nature 
      of practice.
FAU - Graskemper, Joseph
AU  - Graskemper J
AD  - SUNY Stony Brook Dental School, USA. jpgraskemperdds@optonline.net
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Coll Dent
JT  - The Journal of the American College of Dentists
JID - 7503057
SB  - IM
MH  - Curriculum
MH  - Education, Dental/*organization & administration
MH  - Ethics, Dental/*education
MH  - Humans
MH  - New York
EDAT- 2012/01/24 06:00
MHDA- 2012/03/02 06:00
CRDT- 2012/01/24 06:00
PHST- 2012/01/24 06:00 [entrez]
PHST- 2012/01/24 06:00 [pubmed]
PHST- 2012/03/02 06:00 [medline]
PST - ppublish
SO  - J Am Coll Dent. 2011 Fall;78(3):14-7.


PMID- 22263364
OWN - NLM
STAT- MEDLINE
DCOM- 20120301
LR  - 20120123
IS  - 0002-7979 (Print)
IS  - 0002-7979 (Linking)
VI  - 78
IP  - 3
DP  - 2011 Fall
TI  - Dentistry and ethics by the road less traveled.
PG  - 11-3
AB  - In what may be a unique educational career path, this current dental student
      combined predental course requirements with courses and a master's thesis in
      applied medical ethics prior to entering dental education. This background has
      led to leadership opportunities in designing and teaching the ethics program in
      dental school and in the American Student Dental Association. The view of ethics 
      from the students', rather than the practitioners', perspective is certainly
      formative to the future of the profession.
FAU - Tiller, Chrissy
AU  - Tiller C
AD  - Midwestern University College of Dental Medicine, Arizona, USA.
      c.l.tiller@gmail.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Coll Dent
JT  - The Journal of the American College of Dentists
JID - 7503057
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Career Choice
MH  - Education, Dental/*organization & administration
MH  - Ethics, Dental/*education
MH  - Humans
MH  - Students, Dental/*psychology
EDAT- 2012/01/24 06:00
MHDA- 2012/03/02 06:00
CRDT- 2012/01/24 06:00
PHST- 2012/01/24 06:00 [entrez]
PHST- 2012/01/24 06:00 [pubmed]
PHST- 2012/03/02 06:00 [medline]
PST - ppublish
SO  - J Am Coll Dent. 2011 Fall;78(3):11-3.


PMID- 22263363
OWN - NLM
STAT- MEDLINE
DCOM- 20120301
LR  - 20120123
IS  - 0002-7979 (Print)
IS  - 0002-7979 (Linking)
VI  - 78
IP  - 3
DP  - 2011 Fall
TI  - My journey in dental ethics.
PG  - 7-10
AB  - My ethics journal passed through these phases: personal inspiration by those I
      admire in the profession, struggle to incorporate their ideals in daily practice,
      working with like-minded colleagues, and formal education and exposure to broader
      and diverse interests. Now it is time to help others with their journeys.
FAU - Cook, Larry J
AU  - Cook LJ
AD  - Florida Section of ACD, USA. drlarrycook@embarqmail.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Coll Dent
JT  - The Journal of the American College of Dentists
JID - 7503057
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Career Mobility
MH  - *Ethics, Dental/education
MH  - Humans
MH  - Societies, Dental
EDAT- 2012/01/24 06:00
MHDA- 2012/03/02 06:00
CRDT- 2012/01/24 06:00
PHST- 2012/01/24 06:00 [entrez]
PHST- 2012/01/24 06:00 [pubmed]
PHST- 2012/03/02 06:00 [medline]
PST - ppublish
SO  - J Am Coll Dent. 2011 Fall;78(3):7-10.


PMID- 22263362
OWN - NLM
STAT- MEDLINE
DCOM- 20120301
LR  - 20181201
IS  - 0002-7979 (Print)
IS  - 0002-7979 (Linking)
VI  - 78
IP  - 3
DP  - 2011 Fall
TI  - The ethics of writing off a patient's insurance copayment.
PG  - 4-5; author reply 5-6
FAU - Rosen, Robert
AU  - Rosen R
LA  - eng
PT  - Letter
PT  - Comment
PL  - United States
TA  - J Am Coll Dent
JT  - The Journal of the American College of Dentists
JID - 7503057
SB  - IM
CON - J Am Coll Dent. 2011 Summer;78(2):26-33. PMID: 21932739
MH  - Deductibles and Coinsurance/*ethics
MH  - *Ethics, Dental
MH  - Humans
MH  - Insurance, Dental/*ethics
EDAT- 2012/01/24 06:00
MHDA- 2012/03/02 06:00
CRDT- 2012/01/24 06:00
PHST- 2012/01/24 06:00 [entrez]
PHST- 2012/01/24 06:00 [pubmed]
PHST- 2012/03/02 06:00 [medline]
PST - ppublish
SO  - J Am Coll Dent. 2011 Fall;78(3):4-5; author reply 5-6.


PMID- 22263332
OWN - NLM
STAT- MEDLINE
DCOM- 20120203
LR  - 20131121
IS  - 0894-8275 (Print)
IS  - 0894-8275 (Linking)
VI  - 24
IP  - 6
DP  - 2011 Dec
TI  - Postoperative periodontal pain prevention using two dexamethasone medication
      protocols: a double-blind, parallel-group, placebo-controlled randomized clinical
      trial.
PG  - 354-6
AB  - PURPOSE: To assess and compare the efficacy of two different dexamethasone
      protocols on pain prevention following periodontal surgery. METHODS: 60 subjects 
      presenting moderate to severe periodontitis with persisting clinical signs of
      inflammation after nonsurgical periodontal therapy on at least two adjacent teeth
      were scheduled for open flap debridement surgeries. This was a double-blind,
      parallel-group, placebo-controlled randomized clinical trial. Each patient was
      randomly assigned to receive one of the following preoperative medication
      protocols, 1 hour before surgery: Protocol 1 (P1): 4 mg dexamethasone, and
      another 4 mg 8 hours after the first dose; P2: 8 mg dexamethasone; P3: placebo.
      Pain intensity was evaluated hourly for the first 8 hours after surgery using the
      visual analogue scale (VAS). For ethical reasons, patients were instructed to use
      acetaminophen 750 mg as a rescue medication, only in case of pain. RESULTS: P2
      demonstrated to be more effective than P3 at all time periods, except for the 2nd
      hour. P2 was also superior to P1 at 1-(Kruskal-Wallis; P = 0.034), 5- (P = 0.03),
      6- (P = 0.04), 7- (P = 0.005) and 8-hour (P = 0.01) periods. The need for rescue 
      medication was significantly prevented when P2 was used (ANOVA; P = 0.02).
FAU - Steffens, Joao Paulo
AU  - Steffens JP
AD  - Department of Physiology and Pathology, Araraquara Dental School, UNESP -
      Universidade Estadual Paulista, Araraquara, Sao Paulo, Brazil.
FAU - Santos, Fabio Andre
AU  - Santos FA
FAU - Pilatti, Gibson Luiz
AU  - Pilatti GL
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Dent
JT  - American journal of dentistry
JID - 8806701
RN  - 0 (Placebos)
RN  - 7S5I7G3JQL (Dexamethasone)
MH  - Dexamethasone/administration & dosage/*therapeutic use
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pain, Postoperative/*prevention & control
MH  - Placebos
EDAT- 2012/01/24 06:00
MHDA- 2012/02/04 06:00
CRDT- 2012/01/24 06:00
PHST- 2012/01/24 06:00 [entrez]
PHST- 2012/01/24 06:00 [pubmed]
PHST- 2012/02/04 06:00 [medline]
PST - ppublish
SO  - Am J Dent. 2011 Dec;24(6):354-6.


PMID- 22259729
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 2093-369X (Electronic)
IS  - 2093-3681 (Linking)
VI  - 17
IP  - 4
DP  - 2011 Dec
TI  - The development of a korean drug dosing database.
PG  - 267-75
LID - 10.4258/hir.2011.17.4.267 [doi]
AB  - OBJECTIVES: This report describes the development process of a drug dosing
      database for ethical drugs approved by the Korea Food & Drug Administration
      (KFDA). The goal of this study was to develop a computerized system that supports
      physicians' prescribing decisions, particularly in regards to medication dosing. 
      METHODS: The advisory committee, comprised of doctors, pharmacists, and nurses
      from the Seoul National University Bundang Hospital, pharmacists familiar with
      drug databases, KFDA officials, and software developers from the BIT Computer Co.
      Ltd. analyzed approved KFDA drug dosing information, defined the fields and
      properties of the information structure, and designed a management program used
      to enter dosing information. The management program was developed using a web
      based system that allows multiple researchers to input drug dosing information in
      an organized manner. The whole process was improved by adding additional input
      fields and eliminating the unnecessary existing fields used when the dosing
      information was entered, resulting in an improved field structure. RESULTS: A
      total of 16,994 drugs sold in the Korean market in July 2009, excluding the
      exclusion criteria (e.g., radioactivity drugs, X-ray contrast medium), usage and 
      dosing information were made into a database. CONCLUSIONS: The drug dosing
      database was successfully developed and the dosing information for new drugs can 
      be continually maintained through the management mode. This database will be used
      to develop the drug utilization review standards and to provide appropriate
      dosing information.
FAU - Kim, Sun Ah
AU  - Kim SA
AD  - Department of Pharmacy, Ewha Womans University Mokdong Hospital, Seoul, Korea.
FAU - Kim, Jung Hoon
AU  - Kim JH
FAU - Jang, Yoo Jin
AU  - Jang YJ
FAU - Jeon, Man Ho
AU  - Jeon MH
FAU - Hwang, Joong Un
AU  - Hwang JU
FAU - Jeong, Young Mi
AU  - Jeong YM
FAU - Choi, Kyung Suk
AU  - Choi KS
FAU - Lee, Iyn Hyang
AU  - Lee IH
FAU - Jeon, Jin Ok
AU  - Jeon JO
FAU - Lee, Eun Sook
AU  - Lee ES
FAU - Lee, Eun Kyung
AU  - Lee EK
FAU - Kim, Hong Bin
AU  - Kim HB
FAU - Chin, Ho Jun
AU  - Chin HJ
FAU - Ha, Ji Hye
AU  - Ha JH
FAU - Kim, Young Hoon
AU  - Kim YH
FAU - Lee, Byung Koo
AU  - Lee BK
LA  - eng
PT  - Case Reports
DEP - 20111231
PL  - Korea (South)
TA  - Healthc Inform Res
JT  - Healthcare informatics research
JID - 101534553
PMC - PMC3259562
OTO - NOTNLM
OT  - Decision Support Systems
OT  - Dosing
OT  - Drug Utilization Review
EDAT- 2012/01/20 06:00
MHDA- 2012/01/20 06:01
CRDT- 2012/01/20 06:00
PHST- 2011/03/17 00:00 [received]
PHST- 2011/06/13 00:00 [revised]
PHST- 2011/12/08 00:00 [accepted]
PHST- 2012/01/20 06:00 [entrez]
PHST- 2012/01/20 06:00 [pubmed]
PHST- 2012/01/20 06:01 [medline]
AID - 10.4258/hir.2011.17.4.267 [doi]
PST - ppublish
SO  - Healthc Inform Res. 2011 Dec;17(4):267-75. doi: 10.4258/hir.2011.17.4.267. Epub
      2011 Dec 31.


PMID- 22256672
OWN - NLM
STAT- MEDLINE
DCOM- 20120216
LR  - 20120119
IS  - 1040-0435 (Print)
IS  - 1040-0435 (Linking)
VI  - 23
IP  - 4
DP  - 2011 Winter
TI  - International mobility technology research: a Delphi study to identify challenges
      and compensatory strategies.
PG  - 232-42
AB  - We sought to identify logistical and ethical challenges to performing
      wheelchair-related research in low- and middle-income countries and to generate a
      list of compensatory strategies to address these challenges. Thirteen individuals
      with experience in the field participated in an online Delphi study. The surveys 
      asked participants to identify research challenges, suggest strategies to address
      the selected challenges, and critique each other's strategies. Participants
      identified challenges in the use of research techniques, compensation for
      participation that does not result coercion, oral and written translation
      materials, funding for research, collaboration with local professionals, and
      "respect for persons." Effective international mobility research requires time,
      cultural sensitivity, collaboration, and careful planning. An understanding of
      these requirements can allow researchers to anticipate and compensate for common 
      pitfalls of their work, thus making the research more productive and beneficial
      to subjects. Future research is required to verify the general effectiveness of
      compensatory strategies.
FAU - Jefferds, Alexandra N
AU  - Jefferds AN
AD  - Human Engineering Research Laboratories, VA Pittsburgh Healthcare System,
      Pittsburgh, PA 15206, USA.
FAU - Pearlman, Jon L
AU  - Pearlman JL
FAU - Wee, Joy
AU  - Wee J
FAU - Cooper, Rory A
AU  - Cooper RA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Assist Technol
JT  - Assistive technology : the official journal of RESNA
JID - 8917250
MH  - Communication Barriers
MH  - Cross-Cultural Comparison
MH  - *Cultural Competency
MH  - Delphi Technique
MH  - *Developing Countries
MH  - Disabled Persons/rehabilitation
MH  - Evidence-Based Practice
MH  - Humans
MH  - Informed Consent/ethics
MH  - *Internationality
MH  - North America
MH  - Patient Selection/ethics
MH  - Research/economics/*organization & administration
MH  - Research Support as Topic
MH  - Translating
MH  - *Wheelchairs
EDAT- 2012/01/20 06:00
MHDA- 2012/02/18 06:00
CRDT- 2012/01/20 06:00
PHST- 2012/01/20 06:00 [entrez]
PHST- 2012/01/20 06:00 [pubmed]
PHST- 2012/02/18 06:00 [medline]
AID - 10.1080/10400435.2011.614677 [doi]
PST - ppublish
SO  - Assist Technol. 2011 Winter;23(4):232-42. doi: 10.1080/10400435.2011.614677.


PMID- 22256504
OWN - NLM
STAT- MEDLINE
DCOM- 20120301
LR  - 20120119
IS  - 0253-0465 (Print)
IS  - 0253-0465 (Linking)
VI  - 104
IP  - 12
DP  - 2011
TI  - ["Money versus ethics"].
PG  - 67
FAU - Bagnaschi, Pia
AU  - Bagnaschi P
LA  - ita
PT  - Editorial
TT  - Soldi contro etica.
PL  - Switzerland
TA  - Krankenpfl Soins Infirm
JT  - Krankenpflege. Soins infirmiers
JID - 8000153
MH  - Confidentiality/*legislation & jurisprudence
MH  - *Ethics, Nursing
MH  - Humans
MH  - Nurse-Patient Relations/*ethics
MH  - Switzerland
EDAT- 2012/01/20 06:00
MHDA- 2012/03/02 06:00
CRDT- 2012/01/20 06:00
PHST- 2012/01/20 06:00 [entrez]
PHST- 2012/01/20 06:00 [pubmed]
PHST- 2012/03/02 06:00 [medline]
PST - ppublish
SO  - Krankenpfl Soins Infirm. 2011;104(12):67.


PMID- 22256470
OWN - NLM
STAT- MEDLINE
DCOM- 20120209
LR  - 20120119
IS  - 0125-2208 (Print)
IS  - 0125-2208 (Linking)
VI  - 94
IP  - 11
DP  - 2011 Nov
TI  - HIV prevention with positives and disclosure of HIV status: practice and views of
      Thai healthcare providers.
PG  - 1314-20
AB  - OBJECTIVE: The present study provides information from health care providers
      about sexual practices of and preventive and disclosure counseling for People
      Living with HIVand AIDS (PLWHA). MATERIAL AND METHOD: A survey of health care
      providers attending HIV prevention workshops was undertaken using
      self-administered and anonymous questionnaires. RESULTS: Of 678 respondents, 72% 
      were nurses. Ninety-six percent agreed that they had duty to provide prevention
      services and measures. However, less than half (46%) had enough time for
      counseling. Asking health providers to estimate different aspects of sexual
      practice in their patients, the highest chosen band estimation was 'unsafe sex'
      (21-40%), 'partner disclosure' (41-60%) and 'abstinence' (0-10%). When patients
      did not disclose their HIV status to partner most health care providers kept HIV 
      serostatus of patient confidential from their sexual partners. The main reasons
      for not notifying were patients 'rights and fear of adverse effects on patients. 
      Some (9%) did notify the patient's partner directly or indirectly. The main
      notification reasons were for preventing HIV transmission and recognizing the
      partner's right to be informed. Seventy percent agreed that a law should require 
      disclosure of HIV status to husband, wife, or intimate partner. CONCLUSION:
      Health care providers supported the 'Prevention with Positives' strategy.
      HIVstatus disclosure is a continuing ethical dilemma since there are conflicts of
      principle between confidentiality of patients and right to healthy life of their 
      partner Improved or new interventions are needed to prevent HIV transmission with
      consideration of both rights of PLWHA and of HIV risk reduction for sexual
      partner.
FAU - Chaiyamahapurk, Sakchai
AU  - Chaiyamahapurk S
AD  - Health Systems and Policy, Faculty of Medicine, Naresuan University, Phitsanulok,
      Thailand. sakchaichai@hotmail.com
FAU - Pannarunothai, Supasit
AU  - Pannarunothai S
FAU - Nopkesorn, Tawesak
AU  - Nopkesorn T
LA  - eng
PT  - Journal Article
PL  - Thailand
TA  - J Med Assoc Thai
JT  - Journal of the Medical Association of Thailand = Chotmaihet thangphaet
JID - 7507216
SB  - IM
MH  - *Confidentiality
MH  - Counseling
MH  - HIV Infections/*prevention & control
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Physician-Patient Relations
MH  - Sexual Partners
MH  - Thailand
MH  - *Truth Disclosure/ethics
EDAT- 2012/01/20 06:00
MHDA- 2012/02/10 06:00
CRDT- 2012/01/20 06:00
PHST- 2012/01/20 06:00 [entrez]
PHST- 2012/01/20 06:00 [pubmed]
PHST- 2012/02/10 06:00 [medline]
PST - ppublish
SO  - J Med Assoc Thai. 2011 Nov;94(11):1314-20.


PMID- 22255810
OWN - NLM
STAT- MEDLINE
DCOM- 20120808
LR  - 20200928
IS  - 2694-0604 (Electronic)
IS  - 2375-7477 (Linking)
VI  - 2011
DP  - 2011
TI  - Development and usability testing of a parent decision support tool for the
      neonatal intensive care unit.
PG  - 6430-3
LID - 10.1109/IEMBS.2011.6091587 [doi]
AB  - In this paper we present the development and evaluation of a parent decision
      support tool for a neonatal intensive care unit (NICU), known as PPADS or
      Physician and Parent Decision Support. The NICU interprofessional (IP) team uses 
      advanced technology to care for the sickest infants in the hospital, some at the 
      edge of viability. Many difficult care decisions are made daily for this
      vulnerable population. The PPADS tool, a computerized decision support system,
      aims to augment current NICU decision-making by helping parents make more
      informed decisions, improving physician-parent communication, increasing parent
      decision-making satisfaction, decreasing conflict, and increasing decision
      efficiency when faced with ethically challenging situations. The development and 
      evaluation of the PPADS tool followed a five step methodology: assessing the
      clinical environment, establishing the design criteria, developing the system
      design, implementing the system, and performing usability testing. Usability
      testing of the PPADS tool with parents of neonates who have graduated (survived) 
      from a tertiary level NICU demonstrates the usefulness and ease of use of the
      tool.
FAU - Weyand, Sabine A
AU  - Weyand SA
AD  - School of Information Technology & Engineering, University of Ottawa, Ottawa,
      Canada. sabine@weyand.ca
FAU - Frize, Monique
AU  - Frize M
FAU - Bariciak, Erika
AU  - Bariciak E
FAU - Dunn, Sandra
AU  - Dunn S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Annu Int Conf IEEE Eng Med Biol Soc
JT  - Annual International Conference of the IEEE Engineering in Medicine and Biology
      Society. IEEE Engineering in Medicine and Biology Society. Annual International
      Conference
JID - 101763872
SB  - IM
MH  - Communication
MH  - Decision Making
MH  - *Decision Support Techniques
MH  - Equipment Design
MH  - Ethics, Medical
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Newborn, Diseases/*nursing
MH  - Intensive Care Units
MH  - Intensive Care, Neonatal/*methods
MH  - Internet
MH  - *Parents
MH  - Patient Care Team
MH  - Patient Satisfaction
MH  - Professional-Patient Relations
MH  - Software
MH  - User-Computer Interface
EDAT- 2012/01/19 06:00
MHDA- 2012/08/09 06:00
CRDT- 2012/01/19 06:00
PHST- 2012/01/19 06:00 [entrez]
PHST- 2012/01/19 06:00 [pubmed]
PHST- 2012/08/09 06:00 [medline]
AID - 10.1109/IEMBS.2011.6091587 [doi]
PST - ppublish
SO  - Annu Int Conf IEEE Eng Med Biol Soc. 2011;2011:6430-3. doi:
      10.1109/IEMBS.2011.6091587.


PMID- 22254792
OWN - NLM
STAT- MEDLINE
DCOM- 20120612
LR  - 20200928
IS  - 2694-0604 (Electronic)
IS  - 2375-7477 (Linking)
VI  - 2011
DP  - 2011
TI  - Ethical issues in the development of a vestibular prosthesis.
PG  - 2265-8
LID - 10.1109/IEMBS.2011.6090570 [doi]
AB  - During the development of a neural prosthesis, various ethical aspects have to be
      considered. These range from the basic design of the prosthesis and manufacturing
      of the various components and the system using biocompatible materials to
      extensive in vitro and in vivo testing and investigations in the animal model,
      before taking the final step and going to human trials. As medical systems,
      neural prostheses have to be proven absolutely safe before considering any
      clinical study. In this work, the various steps accompanying the development are 
      described taking the example of a vestibular prosthesis currently developed
      within the European project CLONS.
FAU - Poppendieck, Wigand
AU  - Poppendieck W
AD  - Fraunhofer Institute for Biomedical Engineering, Department Medical Engineering &
      Neuroprosthetics, 66386 St Ingbert, Germany.
      wigand.poppendieck@ibmt.fraunhofer.de
FAU - Hoffmann, Klaus-Peter
AU  - Hoffmann KP
FAU - Merfeld, Daniel
AU  - Merfeld D
FAU - Guyot, Jean-Philippe
AU  - Guyot JP
FAU - Micera, Silvestro
AU  - Micera S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Annu Int Conf IEEE Eng Med Biol Soc
JT  - Annual International Conference of the IEEE Engineering in Medicine and Biology
      Society. IEEE Engineering in Medicine and Biology Society. Annual International
      Conference
JID - 101763872
SB  - IM
MH  - Electric Stimulation Therapy/*ethics
MH  - Europe
MH  - Prostheses and Implants/*ethics
MH  - Vestibular Diseases/*prevention & control/*rehabilitation
EDAT- 2012/01/19 06:00
MHDA- 2012/06/13 06:00
CRDT- 2012/01/19 06:00
PHST- 2012/01/19 06:00 [entrez]
PHST- 2012/01/19 06:00 [pubmed]
PHST- 2012/06/13 06:00 [medline]
AID - 10.1109/IEMBS.2011.6090570 [doi]
PST - ppublish
SO  - Annu Int Conf IEEE Eng Med Biol Soc. 2011;2011:2265-8. doi:
      10.1109/IEMBS.2011.6090570.


PMID- 22254559
OWN - NLM
STAT- MEDLINE
DCOM- 20120612
LR  - 20200928
IS  - 2694-0604 (Electronic)
IS  - 2375-7477 (Linking)
VI  - 2011
DP  - 2011
TI  - An integrated vestibular-cochlear prosthesis for restoring balance and hearing.
PG  - 1319-22
LID - 10.1109/IEMBS.2011.6090310 [doi]
AB  - An integrated vestibular-cochlear implant can be rapidly prototyped and
      clinically tested by modifying an existing modern cochlear implant. The
      modifications include addition of gyroscope sensors and reallocation of several
      electrodes that are normally used for auditory nerve stimulation to the
      semicircular canals, while sharing the external DSP processor and the internal
      receiver/stimulator. This paper discusses the validation issues related to
      hardware and software design that arise in integrating electric hearing and
      balance onto a single device. The device's initially targeted population will be 
      deaf individuals who also have vestibular impairment since there is a strong
      ethical justification for vestibular implantation along with minimal additional
      surgical risk. Because of widespread usage of ototoxic drugs and unique genetic
      mutations, the patient population with both impaired hearing and balance function
      is especially prevalent in Asian countries such as China and India. Should such
      an integrated vestibular-cochlear implant be verified, it could be used to
      restore balance or treat a wide array of vestibular disorders.
FAU - Lu, Thomas
AU  - Lu T
AD  - Dept Otolaryngology-Head & Neck Surgery, University of California, Irvine, CA
      92697, USA. telu@uci.edu
FAU - Djalilian, Hamid
AU  - Djalilian H
FAU - Zeng, Fan-Gang
AU  - Zeng FG
FAU - Chen, Hongbin
AU  - Chen H
FAU - Sun, Xiaoan
AU  - Sun X
LA  - eng
GR  - P30 DC008369/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Annu Int Conf IEEE Eng Med Biol Soc
JT  - Annual International Conference of the IEEE Engineering in Medicine and Biology
      Society. IEEE Engineering in Medicine and Biology Society. Annual International
      Conference
JID - 101763872
SB  - IM
MH  - *Acceleration
MH  - Actigraphy/*instrumentation
MH  - Algorithms
MH  - *Cochlear Implants
MH  - Electric Stimulation Therapy/*instrumentation
MH  - Equipment Design
MH  - Equipment Failure Analysis
MH  - Humans
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Systems Integration
MH  - Vestibular Diseases/diagnosis/*physiopathology/*rehabilitation
EDAT- 2012/01/19 06:00
MHDA- 2012/06/13 06:00
CRDT- 2012/01/19 06:00
PHST- 2012/01/19 06:00 [entrez]
PHST- 2012/01/19 06:00 [pubmed]
PHST- 2012/06/13 06:00 [medline]
AID - 10.1109/IEMBS.2011.6090310 [doi]
PST - ppublish
SO  - Annu Int Conf IEEE Eng Med Biol Soc. 2011;2011:1319-22. doi:
      10.1109/IEMBS.2011.6090310.


PMID- 22254261
OWN - NLM
STAT- MEDLINE
DCOM- 20120607
LR  - 20200928
IS  - 2694-0604 (Electronic)
IS  - 2375-7477 (Linking)
VI  - 2011
DP  - 2011
TI  - Multi-scale modeling of glycosylation modulation dynamics in cardiac electrical
      signaling.
PG  - 104-7
LID - 10.1109/IEMBS.2011.6089907 [doi]
AB  - The cardiac action potential (AP) is produced by the orchestrated functions of
      ion channel dynamics. The coordinated functions can be simulated by computational
      cardiac cell models, which could not only overcome the practical and ethical
      limitations in physical experiments but also provide predictive insights on the
      underlying mechanisms. This investigation is aimed at modeling the variations of 
      cardiac electrical signaling due to changes in glycosylation of a voltage-gated
      K+ channel, hERG, responsible for late phase 2 and phase 3 of the human
      ventricular AP. The voltage-dependence of hERG channels steady-state activation
      and inactivation under four glycosylation conditions, i.e., full glycosylation,
      reduced sialylation, mannose-rich and N-Glycanase treated, demonstrated that
      reduced glycosylation modulates hERG channel gating. Here, the proposed
      multi-scale computer model incorporates the measured changes in hERG channel
      gating observed under conditions of reduced glycosylation, and further predicts
      the electrical behaviors of cardiac cells and tissues (cable/ring). The
      multi-scale modeling results show that reduced glycosylation would act to shorten
      the repolarization period of cardiac APs, and distort the AP propagation in
      cardiac tissues. This multi-scale modeling investigation reveals novel mechanisms
      of hERG channel modulation by regulated glycosylation that also impact cardiac
      myocyte and tissue functions. It can potentially lead to new pharmaceutical
      treatments and drug designs for long QT syndrome and cardiac arrhythmia.
FAU - Du, Dongping
AU  - Du D
AD  - Department of Industrial and Management Systems Engineering, University of South 
      Florida, USA.
FAU - Yang, Hui
AU  - Yang H
FAU - Norring, Sarah A
AU  - Norring SA
FAU - Bennett, Eric S
AU  - Bennett ES
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Annu Int Conf IEEE Eng Med Biol Soc
JT  - Annual International Conference of the IEEE Engineering in Medicine and Biology
      Society. IEEE Engineering in Medicine and Biology Society. Annual International
      Conference
JID - 101763872
RN  - 0 (ERG1 Potassium Channel)
RN  - 0 (Ether-A-Go-Go Potassium Channels)
RN  - 0 (KCNH2 protein, human)
RN  - EC 3.2.1.- (Glycoside Hydrolases)
RN  - EC 3.2.1.- (glycanase)
SB  - IM
MH  - Action Potentials/*physiology
MH  - Animals
MH  - Carbohydrate Metabolism/*physiology
MH  - Computer Simulation
MH  - ERG1 Potassium Channel
MH  - Ether-A-Go-Go Potassium Channels/*physiology
MH  - Glycoside Hydrolases/*metabolism
MH  - Glycosylation
MH  - Heart Conduction System/*physiology
MH  - Humans
MH  - Ion Channel Gating/physiology
MH  - *Models, Cardiovascular
MH  - Myocytes, Cardiac/*physiology
EDAT- 2012/01/19 06:00
MHDA- 2012/06/08 06:00
CRDT- 2012/01/19 06:00
PHST- 2012/01/19 06:00 [entrez]
PHST- 2012/01/19 06:00 [pubmed]
PHST- 2012/06/08 06:00 [medline]
AID - 10.1109/IEMBS.2011.6089907 [doi]
PST - ppublish
SO  - Annu Int Conf IEEE Eng Med Biol Soc. 2011;2011:104-7. doi:
      10.1109/IEMBS.2011.6089907.


PMID- 22254127
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 2090-0015 (Electronic)
IS  - 2090-0007 (Linking)
VI  - 2011
DP  - 2011
TI  - Approach to the pretransplant evaluation of the living kidney donor.
PG  - 245738
LID - 10.1155/2011/245738 [doi]
AB  - Evaluation of the potential kidney donor is a complex activity that differs
      substantially from other types of preoperative assessments. The well being of the
      donor, who derives no medical benefit from this surgery, must be assured in both 
      the short term and long term, and the potential adverse consequences to the
      recipient must be determined as well. The criteria that must be met for a person 
      to donate a kidney are rigorous and include medical, social, psychosocial,
      ethical, and legal issues. Donor evaluation can be divided into assessments to
      protect the health and safety of the donor and assessments to protect the health 
      and safety of the recipient. This article provides an approach to evaluating a
      donor, focusing on the complex issues that an evaluator is faced with. A careful 
      assessment of risks and benefits to both the donor and recipient can lead to
      favorable outcomes.
FAU - Sachdeva, Mala
AU  - Sachdeva M
AD  - Division of Kidney Diseases and Hypertension, Department of Medicine, Hofstra
      North Shore-LIJ School of Medicine, Great Neck, NY 11021, USA.
FAU - Bhaskaran, Madhu
AU  - Bhaskaran M
FAU - Molmenti, Ernesto P
AU  - Molmenti EP
FAU - Dalton, Donna
AU  - Dalton D
FAU - Mattana, Joseph
AU  - Mattana J
LA  - eng
PT  - Journal Article
DEP - 20111229
PL  - United States
TA  - J Transplant
JT  - Journal of transplantation
JID - 101519118
PMC - PMC3255285
EDAT- 2012/01/19 06:00
MHDA- 2012/01/19 06:01
CRDT- 2012/01/19 06:00
PHST- 2011/09/30 00:00 [received]
PHST- 2011/11/04 00:00 [accepted]
PHST- 2012/01/19 06:00 [entrez]
PHST- 2012/01/19 06:00 [pubmed]
PHST- 2012/01/19 06:01 [medline]
AID - 10.1155/2011/245738 [doi]
PST - ppublish
SO  - J Transplant. 2011;2011:245738. doi: 10.1155/2011/245738. Epub 2011 Dec 29.


PMID- 22253513
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 0976-2809 (Electronic)
IS  - 0975-9476 (Linking)
VI  - 2
IP  - 4
DP  - 2011 Oct
TI  - "Science means learning to say-I don't know": An interview with Dr. Ashok D.B.
      Vaidya.
PG  - 211-6
LID - 10.4103/0975-9476.90771 [doi]
AB  - Dr. Ashok D.B. Vaidya, the stalwart in the fields of Experimental Pharmacology,
      Clinical Pharmacology, and Reverse Pharmacology turns 75 on Nov, 27, 2011. A
      former Clinical Research Head of CIBA Geigy Research Centre, his name has been
      synonymous with the concept of the Golden Triangle for resurgence of Ayurveda and
      its reinterpretation in modern scientific terms. At a time when most fields are
      populated by intellectual dwarfs and unethical operators, he stands like a
      giant-a scientist, a philosopher, and an ardent fighter for ethical values. In
      this free-wheeling interview with Ravindra R.Pandharinath, he discusses the
      milestones in his life, his inspirations, and dreams for the confluence of modern
      science, modern medicine, and Ayurveda as the new health care model for the 21st 
      century.
FAU - Pandharinath, Ravindra R
AU  - Pandharinath RR
AD  - SVKM's NMIMS School of Pharmacy and Technology Management, Shirpur (Dhule),
      Maharashtra, India.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Ayurveda Integr Med
JT  - Journal of Ayurveda and integrative medicine
JID - 101551404
PMC - PMC3255454
OTO - NOTNLM
OT  - Dr. Ashok Vaidya
OT  - golden triangle
OT  - reverse pharmacology
EDAT- 2012/01/19 06:00
MHDA- 2012/01/19 06:01
CRDT- 2012/01/19 06:00
PHST- 2011/10/11 00:00 [received]
PHST- 2011/10/17 00:00 [revised]
PHST- 2011/10/24 00:00 [accepted]
PHST- 2012/01/19 06:00 [entrez]
PHST- 2012/01/19 06:00 [pubmed]
PHST- 2012/01/19 06:01 [medline]
AID - 10.4103/0975-9476.90771 [doi]
AID - JAIM-2-211 [pii]
PST - ppublish
SO  - J Ayurveda Integr Med. 2011 Oct;2(4):211-6. doi: 10.4103/0975-9476.90771.


PMID- 22253121
OWN - NLM
STAT- MEDLINE
DCOM- 20160423
LR  - 20181201
VI  - 15
IP  - 3 Pt 2
DP  - 2011 Jul-Sep
TI  - [Newborn at the limit of viability. Part 2: Recommendations regarding treatment
      of mother and newborn at the limit of viability considering ethical aspects].
PG  - 356-67
AB  - The first Polish recommendations regarding the treatment of mothers and infants
      born at the limit of viability are the result of 1,5 years of work by the Team
      for Ethical Recommendations in Perinatology, consisting not only of
      gynecologists-obstetricians and neonatologists, but also geneticists,
      psychologists, ethics specialists, philosophers and lawyers. Their development
      was based on similar standards already existing in other European countries, as
      well as in Australia, Canada and the USA. The recommendations were accepted by
      the National Consultant for Neonatology, Polish Gynecological Society, Polish
      Perinatal Medicine Society and Polish Pediatric Society. The Recommendations
      indicate ethical problems and presented transfer of information among the members
      of the treatment team as well as between the team and the parents of extremely
      immature newborns. The necessity of informing parents about their infant's
      chances for survival has been emphasized, as well as the need to hear their
      opinions and expectations. A Prenatal Consultation Card and Newborn Treatment
      Card have been attached to the recommendations, as a tool for presenting
      decisions and parents' opinions. Problems concerning accurate determination of
      gestational age and biological maturity of the foetus have also been discussed.
      Furthermore, on the basis of international research, morbidity and mortality data
      on infants born at the limit of viability have been presented. The paper also
      presents recommendations concerning: in utero transport, cesarean section and
      undertaking resuscitation as opposed to palliative care in newborns depending on 
      their gestational age. It has been emphasized that gestational age cannot be the 
      only criteria in the course of making decisions. Individual pre- and post-natal
      factors influencing the prognosis should also be taken into account.
      Recommendations allow both for the situation when the gestational age is
      precisely determined and when it is uncertain. Attention has been drawn to the
      need of long-term assessment of development in this group of children. The
      procedure in case of the infants' death has also been discussed.
FAU - Rutkowska, Magdalena
AU  - Rutkowska M
AD  - Klinika Neonatologii i Intensywnej Terapii Noworodka, Instytut Matki i Dziecka,
      ul. Kasprzaka 17a, 01-211 Warszawa, magda_rutkowska@poczta.onet.pl.
LA  - eng
LA  - pol
PT  - Journal Article
PL  - Poland
TA  - Med Wieku Rozwoj
JT  - Medycyna wieku rozwojowego
JID - 100928610
SB  - IM
MH  - *Gestational Age
MH  - Humans
MH  - Infant Care
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - *Mothers
MH  - Neonatology
MH  - Parents
MH  - Resuscitation
EDAT- 2012/01/19 06:00
MHDA- 2016/04/24 06:00
CRDT- 2012/01/19 06:00
PHST- 2012/01/19 06:00 [entrez]
PHST- 2012/01/19 06:00 [pubmed]
PHST- 2016/04/24 06:00 [medline]
PST - ppublish
SO  - Med Wieku Rozwoj. 2011 Jul-Sep;15(3 Pt 2):356-67.


PMID- 22253120
OWN - NLM
STAT- MEDLINE
DCOM- 20160423
LR  - 20181201
VI  - 15
IP  - 3 Pt 2
DP  - 2011 Jul-Sep
TI  - [Newborn at the limit of viability. Part 1: Ethical dilemmas, international
      recommendations].
PG  - 349-55
AB  - Immense scientific and technological progress in perinatal medicine during the
      1990s enabled to save extremely immature newborns. The fact faced doctors with
      new challenges and ethical problems regarding especially infants born at the
      limit of viability (22-26 weeks of gestation). The aim of this study is an
      attempt to answer the question concerning the mode of operation in the delivery
      room and/or NICU towards this group of infants. Decisions may concern undertaking
      resuscitation, limiting medical procedures and the use of palliative care.
      Materials for preparation of this paper included international recommendations
      developed by teams of specialists (part 1), as well as Polish recommendations
      (part 2). The first part presents world epidemiological data regarding survival
      rate and long-term developmental assessment of extremely low gestational age
      infants, indicating difficulties in interpretation of some of the research. We
      also emphasized the discrepancies in precise evaluation of gestational age, which
      is of great significance for qualifying the newborn into the group unable to
      survive or at the limit of viability. For better assessment of the research,
      recommendations developed by FIGO Committee in 1994 are presented: "Ethical
      aspects in management of newborn infants at the threshold of viability." In the
      discussion part we presented differences between world recommendations regarding 
      newborns at the limit of viability, emphasizing the need to define the "grey
      zone" (gestational age at which there is doubt about the newborns' viability and 
      development and, as a result, the possibility of making "good" therapeutic
      decisions is limited). In summary it has been emphasized that at the current
      state of knowledge decisions cannot be based solely on gestational age and
      estimated body weight, but other factors improving or worsening the prognosis
      should be taken into consideration as well. Finally the situation in Poland is
      discussed, indicating problems regarding this group of newborns. It is also
      emphasized that a Team for Ethical Recommendations in Perinatology, appointed in 
      2009, developed recommendations which are discussed in the second part of the
      paper.
FAU - Rutkowska, Magdalena
AU  - Rutkowska M
AD  - Klinika Neonatologii i Intensywnej Terapii Noworodka, Instytut Matki i Dziecka,
      ul. Kasprzaka 17a, 01-211 Warszawa, magda_rutkowska@poczta.onet.pl.
LA  - eng
LA  - pol
PT  - Journal Article
PL  - Poland
TA  - Med Wieku Rozwoj
JT  - Medycyna wieku rozwojowego
JID - 100928610
SB  - IM
MH  - *Gestational Age
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Palliative Care
MH  - Prognosis
MH  - *Resuscitation
MH  - Survival Rate
EDAT- 2012/01/19 06:00
MHDA- 2016/04/24 06:00
CRDT- 2012/01/19 06:00
PHST- 2012/01/19 06:00 [entrez]
PHST- 2012/01/19 06:00 [pubmed]
PHST- 2016/04/24 06:00 [medline]
PST - ppublish
SO  - Med Wieku Rozwoj. 2011 Jul-Sep;15(3 Pt 2):349-55.


PMID- 22251502
OWN - NLM
STAT- MEDLINE
DCOM- 20120228
LR  - 20220318
IS  - 1878-8769 (Electronic)
IS  - 1878-8750 (Linking)
VI  - 76
IP  - 6
DP  - 2011 Dec
TI  - Deep brain stimulation and ethics: perspectives from a multisite qualitative
      study of Canadian neurosurgical centers.
PG  - 537-47
LID - 10.1016/j.wneu.2011.05.033 [doi]
AB  - OBJECTIVE: Deep brain stimulation (DBS) is an approved neurosurgical intervention
      for motor disorders such as Parkinson disease. The emergence of psychiatric uses 
      for DBS combined with the fact that it is an invasive and expensive procedure
      creates important ethical and social challenges in the delivery of care that need
      further examination. We endeavored to examine health care provider perspectives
      on ethical and social challenges encountered in DBS. METHODS: Health care
      providers working in Canadian DBS surgery programs participated in a
      semistructured interview to identify and characterize ethical and social
      challenges of DBS. A content analysis of the interviews was conducted. RESULTS:
      Several key ethical issues, such as patient screening and resource allocation,
      were identified by members of neurosurgical teams. Providers described challenges
      in selecting patients for DBS on the basis of unclear evidence-based guidance
      regarding behavioral issues or cognitive criteria. Varied contexts of resource
      allocation, including some very challenging schemas, were also reported. In
      addition, the management of patients in the community was highlighted as a source
      of ethical and clinical complexity, given the need for coordinated long-term
      care. CONCLUSIONS: This study provides insights into the complexity of ethical
      challenges that providers face in the use of DBS across different neurosurgical
      centers. We propose actions for health care providers for the long-term care and 
      postoperative monitoring of patients with DBS. More data on patient perspectives 
      in DBS would complement the understanding of key challenges, as well as
      contribute to best practices, for patient selection, management, and resource
      allocation.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Bell, Emily
AU  - Bell E
AD  - Neuroethics Research Unit, Institut de recherches cliniques de Montreal,
      Montreal, Quebec, Canada.
FAU - Maxwell, Bruce
AU  - Maxwell B
FAU - McAndrews, Mary Pat
AU  - McAndrews MP
FAU - Sadikot, Abbas
AU  - Sadikot A
FAU - Racine, Eric
AU  - Racine E
LA  - eng
GR  - NNF 80045/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - World Neurosurg
JT  - World neurosurgery
JID - 101528275
SB  - IM
CIN - World Neurosurg. 2011 Dec;76(6):518-9. PMID: 22251494
MH  - Canada/epidemiology
MH  - Deep Brain Stimulation/*ethics/*statistics & numerical data
MH  - Delivery of Health Care/ethics/statistics & numerical data
MH  - Equipment Failure
MH  - Ethics, Research
MH  - Evidence-Based Medicine
MH  - Health Personnel/statistics & numerical data
MH  - Humans
MH  - Long-Term Care/ethics
MH  - Movement Disorders/surgery/therapy
MH  - Neurosurgery/*ethics/*statistics & numerical data
MH  - Patient Care Team
MH  - Patient Selection/ethics
MH  - Resource Allocation/ethics
MH  - Socioeconomic Factors
EDAT- 2012/01/19 06:00
MHDA- 2012/03/01 06:00
CRDT- 2012/01/19 06:00
PHST- 2010/10/13 00:00 [received]
PHST- 2011/03/18 00:00 [revised]
PHST- 2011/05/13 00:00 [accepted]
PHST- 2012/01/19 06:00 [entrez]
PHST- 2012/01/19 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - S1878-8750(11)00617-6 [pii]
AID - 10.1016/j.wneu.2011.05.033 [doi]
PST - ppublish
SO  - World Neurosurg. 2011 Dec;76(6):537-47. doi: 10.1016/j.wneu.2011.05.033.


PMID- 22248951
OWN - NLM
STAT- MEDLINE
DCOM- 20120516
LR  - 20151119
IS  - 1119-3077 (Print)
VI  - 14
IP  - 4
DP  - 2011 Oct-Dec
TI  - Knowledge of human immunodeficiency virus post-exposure prophylaxis among doctors
      in a Nigerian tertiary hospital.
PG  - 464-6
LID - 10.4103/1119-3077.91757 [doi]
AB  - BACKGROUND: The mainstay of prevention of occupationally-acquired HIV infection
      is compliance with universal precautions. Appropriate post-exposure prophylaxis
      is an integral part of prevention, control and workplace safety. This study was
      undertaken to assess the level of knowledge of post-exposure prophylaxis (PEP)
      against human immunodeficiency virus (HIV) among doctors in Federal Medical
      Centre, Gombe, Nigeria. MATERIALS AND METHODS: Ethical committee approval for the
      conduct of the study was obtained. Questionnaires were served to all cadres of
      doctors from house officers to consultants; it was completed and returned on
      anonymous basis. RESULTS: Sixty six (88.0%) of the 75 distributed questionnaires 
      were returned completed and formed the basis of further analysis. The overall
      knowledge level of post-exposure prophylaxis against human immunodeficiency virus
      infection was very low. About 62.1% are aware of the existence of PEP policy in
      the hospital. The level of knowledge concerning the high-risk fluid and three
      drugs used in PEP is high. Over 90% are not aware of the risk of sero-conversion 
      following significant needle-sticks injury and mucous membrane exposure. The
      study also revealed poor knowledge concerning actions to be taken, how soon to
      commence the PEP treatment and the duration of medication following needle stick 
      injury. More than 50% of the surveyed doctors had experienced significant
      exposure to potentially infective materials and none reported or sought PEP
      advice. CONCLUSION: There is the need to educate the doctors and other health
      workers about the PEP guideline policy, what to do in the event of injury, whom
      to contact and the importance of seeking urgent advice following injury or
      exposure.
FAU - Esin, I A
AU  - Esin IA
AD  - Department of Surgery, Federal Medical Centre, Gombe, Nigeria.
      esin192002@yahoo.com
FAU - Alabi, S
AU  - Alabi S
FAU - Ojo, E
AU  - Ojo E
FAU - Ajape, A A
AU  - Ajape AA
LA  - eng
PT  - Journal Article
PL  - India
TA  - Niger J Clin Pract
JT  - Nigerian journal of clinical practice
JID - 101150032
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - Anti-HIV Agents/*administration & dosage
MH  - Female
MH  - HIV Infections/*prevention & control/transmission
MH  - *Health Knowledge, Attitudes, Practice
MH  - Hospitals, Teaching
MH  - Humans
MH  - Infectious Disease Transmission, Patient-to-Professional/*prevention & control
MH  - Male
MH  - Needlestick Injuries
MH  - Nigeria
MH  - *Occupational Exposure
MH  - Patient Acceptance of Health Care
MH  - *Physicians
MH  - *Post-Exposure Prophylaxis
MH  - Surveys and Questionnaires
MH  - Universal Precautions
EDAT- 2012/01/18 06:00
MHDA- 2012/05/17 06:00
CRDT- 2012/01/18 06:00
PHST- 2012/01/18 06:00 [entrez]
PHST- 2012/01/18 06:00 [pubmed]
PHST- 2012/05/17 06:00 [medline]
AID - NigerJClinPract_2011_14_4_464_91757 [pii]
AID - 10.4103/1119-3077.91757 [doi]
PST - ppublish
SO  - Niger J Clin Pract. 2011 Oct-Dec;14(4):464-6. doi: 10.4103/1119-3077.91757.


PMID- 22248937
OWN - NLM
STAT- MEDLINE
DCOM- 20120516
LR  - 20191210
IS  - 1119-3077 (Print)
VI  - 14
IP  - 4
DP  - 2011 Oct-Dec
TI  - Sonographic evaluation of uterine cervical dimension within 4-24 weeks of
      pregnancy.
PG  - 400-4
LID - 10.4103/1119-3077.91743 [doi]
AB  - OBJECTIVE: To determine the normal range of uterine cervix within 4-24 weeks of
      pregnancy and also assess whether variations are related to some selected
      extraneous human conditions. SETTING AND DESIGN: This was a prospective study
      conducted in University of Benin Teaching Hospital, Benin, Nigeria, and Nigerian 
      National Petroleum Cooperation Health Centre, Warri, Nigeria. MATERIALS AND
      METHODS: A prospective ultrasonographic (USS) study of uterine cervical dimension
      of 150 pregnant women within 4-24 weeks gestational age in two sonographic
      centers in Nigeria between January 2007 and October 2007 was conducted. The
      patients were examined by the authors. The uterine cervical dimensions (length,
      upper lip diameter, and lower lip diameter) were taken by means of
      ultrasonography. In addition, vital history, height and weight of patients were
      documented. The vital history included the age, number of childbirths, number of 
      induced abortion, miscarriages and family history of miscarriages. Using
      Statistical program of social science (SPSS), the data were analyzed. Informed
      consent was obtained from all the patients and the study was done in line with
      the ethical guidelines of the centers. RESULTS: The following uterine cervical
      dimensions were obtained: mean cervical length of 6.14 cm and standard deviation 
      of 2.0, and the upper and lower lips' uterine cervical diameters of 1.81 and 1.76
      cm, respectively, with standard deviations of 0.86 and 0.71, respectively. There 
      was no significant correlation of dimensions of uterine cervix to the
      aforementioned extraneous human condition. However, the increasing number of
      miscarriages correlated with decreasing length or shortness of the cervix.
      CONCLUSION: Uterine cervical dimension in pregnancy between 4 and 24 weeks is
      reproducible with sonographic documentation and the following normal ranges were 
      deduced: cervical length (6.14 +/- 2.0 cm), upper lip (1.81 +/- 0.86 cm) and
      lower lip (1.76 +/- 0.71 cm). The study revealed that increasing number of
      miscarriages was associated with effacement or reduction in the cervical length.
FAU - Tobechukwu, M T
AU  - Tobechukwu MT
AD  - Department of Radiology, University of Benin Teaching Hospital, Benin City,
      Nigeria. tmarchie2000@yahoo.com
FAU - Ose-Emenim, I B
AU  - Ose-Emenim IB
FAU - Ehinwenma, O
AU  - Ehinwenma O
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - India
TA  - Niger J Clin Pract
JT  - Nigerian journal of clinical practice
JID - 101150032
SB  - IM
MH  - Adult
MH  - Cervix Uteri/*anatomy & histology/*diagnostic imaging
MH  - Female
MH  - Humans
MH  - Nigeria
MH  - *Pregnancy
MH  - Pregnancy Trimester, First
MH  - Pregnancy Trimester, Second
MH  - Prospective Studies
MH  - Reference Values
MH  - Reproductive History
MH  - Ultrasonography
MH  - Young Adult
EDAT- 2012/01/18 06:00
MHDA- 2012/05/17 06:00
CRDT- 2012/01/18 06:00
PHST- 2012/01/18 06:00 [entrez]
PHST- 2012/01/18 06:00 [pubmed]
PHST- 2012/05/17 06:00 [medline]
AID - NigerJClinPract_2011_14_4_400_91743 [pii]
AID - 10.4103/1119-3077.91743 [doi]
PST - ppublish
SO  - Niger J Clin Pract. 2011 Oct-Dec;14(4):400-4. doi: 10.4103/1119-3077.91743.


PMID- 22248893
OWN - NLM
STAT- MEDLINE
DCOM- 20120517
LR  - 20131121
IS  - 0974-5998 (Electronic)
IS  - 0974-5998 (Linking)
VI  - 8
IP  - 3
DP  - 2011 Sep-Dec
TI  - Comparing caudal and penile nerve blockade using bupivacaine in hypospadias
      repair surgeries in children.
PG  - 294-7
LID - 10.4103/0189-6725.91673 [doi]
AB  - BACKGROUND: Caudal anaesthesia is recommended for most surgical procedures of the
      lower part of the body, mainly below the umbilicus. It has been well established 
      that a dorsal penile nerve block immediately after surgery decreases
      postoperative pain in children undergoing hypospadias repair. This study aimed to
      compare caudal or penile nerve block using bupivacaine in postoperative pain
      control in hypospadias repair in children. PATIENTS AND METHODS: After local
      ethical committee approval and obtaining informed parental consent, 85 American
      society of Anesthesiologists status I and II patients, aged 6 months to 6 years
      old, undergoing hypospadias repair, were prospectively enrolled in this study.
      The patients were randomly divided into the following two groups: Caudal block
      was performed in 44 and penile block was performed in 41 patients.
      Cardiorespiratory systems data, analgesic requirement and complications were
      compared between the groups. RESULTS: There were statistically significant
      haemodynamic (blood pressure and heart rate) alteration during operation in each 
      group (P<0.01). The haemodynamic parameters were stable during operation in
      successful blocks in both groups. Caudal block success rate is 97.7%, whereas in 
      penile block is 92.6%. Nineteen of 43 patients (44%) in caudal group and 29 of 41
      patients (70%) in penile group received analgesia in the postoperative period and
      this difference was significant between the two groups (P = 0.025). CONCLUSIONS: 
      Without ultrasonography and with blind block, with anatomic landmarks only, the
      caudal block success rate is high and if there is no contraindication for caudal 
      block, it is the best choice in children under 6 years old (or 25 kg) for
      hypospadias repair.
FAU - Seyedhejazi, Mahin
AU  - Seyedhejazi M
AD  - Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz,
      Iran.
FAU - Azerfarin, Rasoul
AU  - Azerfarin R
FAU - Kazemi, Fahime
AU  - Kazemi F
FAU - Amiri, Maryam
AU  - Amiri M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - India
TA  - Afr J Paediatr Surg
JT  - African journal of paediatric surgery : AJPS
JID - 101255062
RN  - 0 (Anesthetics, Local)
RN  - Y8335394RO (Bupivacaine)
SB  - IM
MH  - *Anesthetics, Local
MH  - *Bupivacaine
MH  - Child, Preschool
MH  - Humans
MH  - Hypospadias/*surgery
MH  - Infant
MH  - Male
MH  - Nerve Block/*methods
MH  - Pain, Postoperative/*prevention & control
MH  - Prospective Studies
EDAT- 2012/01/18 06:00
MHDA- 2012/05/18 06:00
CRDT- 2012/01/18 06:00
PHST- 2012/01/18 06:00 [entrez]
PHST- 2012/01/18 06:00 [pubmed]
PHST- 2012/05/18 06:00 [medline]
AID - AfrJPaediatrSurg_2011_8_3_294_91673 [pii]
AID - 10.4103/0189-6725.91673 [doi]
PST - ppublish
SO  - Afr J Paediatr Surg. 2011 Sep-Dec;8(3):294-7. doi: 10.4103/0189-6725.91673.


PMID- 22247813
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130109
LR  - 20211021
IS  - 2158-8341 (Electronic)
IS  - 2158-8333 (Linking)
VI  - 8
IP  - 12
DP  - 2011 Dec
TI  - Should psychiatrists self disclose?
PG  - 14-7
AB  - The extent to which psychiatrists disclose personal information about their
      feelings, their pasts, and themselves to their patients has always been an
      important ethical and clinical question. In the past, psychiatrists tended to
      believe they should not self disclose personal information to their patients,
      mainly to help patients by exploring their transference. More recent work has
      suggested that self disclosing by the psychiatrist may benefit some patients and 
      cause harm to other patients. This article presents the author's present
      understanding of some of the core pros and cons of self disclosing by the
      psychiatrist, as well as some specific contexts in which self disclosure is
      indicated or should be avoided.
FAU - Howe, Edmund
AU  - Howe E
AD  - Department of Psychiatry, Center for the Study of Traumatic Stress, Uniformed
      Services University of the Health Sciences, Bethesda, Maryland, USA.
      ehowe@usuhs.mil
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Innov Clin Neurosci
JT  - Innovations in clinical neuroscience
JID - 101549695
PMC - PMC3257982
OTO - NOTNLM
OT  - Ethics
OT  - Marsha Linehan
OT  - being "real,"
OT  - gay patients
OT  - gay psychiatrists
OT  - harm
OT  - hope
OT  - intrusive
OT  - minority groups
OT  - normalization
OT  - patient trust
OT  - psychiatrists
OT  - psychiatrists and divorce
OT  - psychiatrists and pregnancy
OT  - psychiatrists who are ill
OT  - psychiatrists' feelings
OT  - self disclosure
OT  - shame
OT  - the internet
OT  - transference
EDAT- 2012/01/17 06:00
MHDA- 2012/01/17 06:01
CRDT- 2012/01/17 06:00
PHST- 2012/01/17 06:00 [entrez]
PHST- 2012/01/17 06:00 [pubmed]
PHST- 2012/01/17 06:01 [medline]
PST - ppublish
SO  - Innov Clin Neurosci. 2011 Dec;8(12):14-7.


PMID- 22247747
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1871-4757 (Print)
IS  - 1871-4757 (Linking)
VI  - 5
IP  - 3
DP  - 2011 Dec
TI  - The Social and Ethical Acceptability of NBICs for Purposes of Human Enhancement: 
      Why Does the Debate Remain Mired in Impasse?
PG  - 295-307
AB  - The emergence and development of convergent technologies for the purpose of
      improving human performance, including nanotechnology, biotechnology, information
      sciences, and cognitive science (NBICs), open up new horizons in the debates and 
      moral arguments that must be engaged by philosophers who hope to take seriously
      the question of the ethical and social acceptability of these technologies. This 
      article advances an analysis of the factors that contribute to confusion and
      discord on the topic, in order to help in understanding why arguments that form a
      part of the debate between transhumanism and humanism result in a philosophical
      and ethical impasse: 1. The lack of clarity that emerges from the fact that any
      given argument deployed (arguments based on nature and human nature, dignity, the
      good life) can serve as the basis for both the positive and the negative
      evaluation of NBICs. 2. The impossibility of providing these arguments with
      foundations that will enable others to deem them acceptable. 3. The difficulty of
      applying these same arguments to a specific situation. 4. The ineffectiveness of 
      moral argument in a democratic society. The present effort at communication about
      the difficulties of the argumentation process is intended as a necessary first
      step towards developing an interdisciplinary response to those difficulties.
FAU - Beland, Jean-Pierre
AU  - Beland JP
FAU - Patenaude, Johane
AU  - Patenaude J
FAU - Legault, Georges A
AU  - Legault GA
FAU - Boissy, Patrick
AU  - Boissy P
FAU - Parent, Monelle
AU  - Parent M
LA  - eng
PT  - Journal Article
DEP - 20111111
PL  - Netherlands
TA  - Nanoethics
JT  - Nanoethics
JID - 101311055
PMC - PMC3250607
EDAT- 2012/01/17 06:00
MHDA- 2012/01/17 06:01
CRDT- 2012/01/17 06:00
PHST- 2011/08/04 00:00 [received]
PHST- 2011/10/16 00:00 [accepted]
PHST- 2012/01/17 06:00 [entrez]
PHST- 2012/01/17 06:00 [pubmed]
PHST- 2012/01/17 06:01 [medline]
AID - 10.1007/s11569-011-0133-z [doi]
AID - 133 [pii]
PST - ppublish
SO  - Nanoethics. 2011 Dec;5(3):295-307. doi: 10.1007/s11569-011-0133-z. Epub 2011 Nov 
      11.


PMID- 22247746
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1871-4757 (Print)
IS  - 1871-4757 (Linking)
VI  - 5
IP  - 3
DP  - 2011 Dec
TI  - Moral Arguments in the Debate over Nanotechnologies: Are We Talking Past Each
      Other?
PG  - 285-293
AB  - How are we to understand the fact that the philosophical debate over
      nanotechnologies has been reduced to a clash of seemingly preprogrammed arguments
      and counterarguments that paralyzes all rational discussion of the ultimate
      ethical question of social acceptability in matters of nanotechnological
      development? With this issue as its starting point, the study reported on here,
      intended to further comprehension of the issues rather than provide a
      cause-and-effect explanation, seeks to achieve a rational grasp of what is being 
      said through the appeals made to this or that principle in the range of arguments
      put forward in publications on the subject. We present the results of the study's
      analyses in two parts. In the first, we lay out the seven categories of argument 
      that emerged from an analysis of the literature: the arguments based on nature,
      dignity, the good life, utility, equity, autonomy, and rights. In the second
      part, we present the background moral stances that support each category of
      argument. Identifying the different categories of argument and the moral stance
      that underlies each category will enable a better grasp of the reasons for the
      multiplicity of the arguments that figure in discussions of the acceptability of 
      nanotechnologies and will ultimately contribute to overcoming the tendency
      towards talking past each other that all too often disfigures the exchange.
      Clarifying the implications of the moral arguments deployed in the debate over
      nanotechnologies may make it possible to reduce the confusion observable in these
      exchanges and contribute to a better grasp of the reasons for their current
      unproductiveness.
FAU - Patenaude, Johane
AU  - Patenaude J
FAU - Legault, Georges A
AU  - Legault GA
FAU - Beland, Jean-Pierre
AU  - Beland JP
FAU - Parent, Monelle
AU  - Parent M
FAU - Boissy, Patrick
AU  - Boissy P
LA  - eng
PT  - Journal Article
DEP - 20111027
PL  - Netherlands
TA  - Nanoethics
JT  - Nanoethics
JID - 101311055
PMC - PMC3250612
EDAT- 2012/01/17 06:00
MHDA- 2012/01/17 06:01
CRDT- 2012/01/17 06:00
PHST- 2011/07/05 00:00 [received]
PHST- 2011/10/10 00:00 [accepted]
PHST- 2012/01/17 06:00 [entrez]
PHST- 2012/01/17 06:00 [pubmed]
PHST- 2012/01/17 06:01 [medline]
AID - 10.1007/s11569-011-0132-0 [doi]
AID - 132 [pii]
PST - ppublish
SO  - Nanoethics. 2011 Dec;5(3):285-293. doi: 10.1007/s11569-011-0132-0. Epub 2011 Oct 
      27.


PMID- 22247745
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1871-4757 (Print)
IS  - 1871-4757 (Linking)
VI  - 5
IP  - 3
DP  - 2011 Dec
TI  - Ethics and Nanopharmacy: Value Sensitive Design of New Drugs.
PG  - 269-283
AB  - Although applications are being developed and have reached the market,
      nanopharmacy to date is generally still conceived as an emerging technology. Its 
      concept is ill-defined. Nanopharmacy can also be construed as a converging
      technology, which combines features of multiple technologies, ranging from
      nanotechnology to medicine and ICT. It is still debated whether its features give
      rise to new ethical issues or that issues associated with nanopharma are merely
      an extension of existing issues in the underlying fields. We argue here that,
      regardless of the alleged newness of the ethical issues involved, developments
      occasioned by technological advances affect the roles played by stakeholders in
      the field of nanopharmacy to such an extent that this calls for a different
      approach to responsible innovation in this field. Specific features associated
      with nanopharmacy itself and features introduced to the associated converging
      technologies- bring about a shift in the roles of stakeholders that call for a
      different approach to responsibility. We suggest that Value Sensitive Design is a
      suitable framework to involve stakeholders in addressing moral issues responsibly
      at an early stage of development of new nanopharmaceuticals.
FAU - Timmermans, Job
AU  - Timmermans J
FAU - Zhao, Yinghuan
AU  - Zhao Y
FAU - van den Hoven, Jeroen
AU  - van den Hoven J
LA  - eng
PT  - Journal Article
DEP - 20111109
PL  - Netherlands
TA  - Nanoethics
JT  - Nanoethics
JID - 101311055
PMC - PMC3250608
EDAT- 2012/01/17 06:00
MHDA- 2012/01/17 06:01
CRDT- 2012/01/17 06:00
PHST- 2011/10/11 00:00 [received]
PHST- 2011/10/21 00:00 [accepted]
PHST- 2012/01/17 06:00 [entrez]
PHST- 2012/01/17 06:00 [pubmed]
PHST- 2012/01/17 06:01 [medline]
AID - 10.1007/s11569-011-0135-x [doi]
AID - 135 [pii]
PST - ppublish
SO  - Nanoethics. 2011 Dec;5(3):269-283. doi: 10.1007/s11569-011-0135-x. Epub 2011 Nov 
      9.


PMID- 22247588
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 0735-7028 (Print)
IS  - 0735-7028 (Linking)
VI  - 42
IP  - 6
DP  - 2011 Dec
TI  - Benefits and Challenges of Conducting Psychotherapy by Telephone.
PG  - 543-549
AB  - Telephone-delivered psychotherapy has increased utility as a method of service
      delivery in the current world, where a number of barriers, including economic
      hardships and limited access to care, may prevent people from receiving the
      treatment they need. This method of service provision is practical and has the
      potential to reach large numbers of underserved people in a cost-effective
      manner. The aim of this paper is to review the state-of-the-art of
      telephone-delivered psychotherapy and to identify improvements and possible
      solutions to challenges. Results of randomized controlled trials indicate high
      client acceptance and positive outcomes with this method of delivering
      psychotherapy. Nonetheless, psychotherapists wishing to deliver psychotherapy by 
      telephone face a number of challenges, including a lack of control over the
      environment, potential compromises of privacy and confidentiality, developing
      therapeutic alliance without face-to-face contact, ethical and legal issues in
      providing psychotherapy by telephone, handling crisis situations at a distance,
      and psychotherapist adjustment to conducting psychotherapy in an alternative
      manner. There remains a need for further research, including direct comparisons
      of face-to-face psychotherapy with telephone-delivered psychotherapy and
      feasibility of telephone delivery of psychotherapies other than cognitive
      behavioral therapy.
FAU - Brenes, Gretchen A
AU  - Brenes GA
AD  - Wake Forest University School of Medicine.
FAU - Ingram, Cobi W
AU  - Ingram CW
FAU - Danhauer, Suzanne C
AU  - Danhauer SC
LA  - eng
GR  - K23 MH065281/MH/NIMH NIH HHS/United States
GR  - K23 MH065281-01A2/MH/NIMH NIH HHS/United States
GR  - R01 MH083664/MH/NIMH NIH HHS/United States
GR  - R01 MH083664-01A2/MH/NIMH NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Prof Psychol Res Pr
JT  - Professional psychology, research and practice
JID - 8309175
PMC - PMC3256923
MID - NIHMS337564
EDAT- 2012/01/17 06:00
MHDA- 2012/01/17 06:01
CRDT- 2012/01/17 06:00
PHST- 2012/01/17 06:00 [entrez]
PHST- 2012/01/17 06:00 [pubmed]
PHST- 2012/01/17 06:01 [medline]
AID - 10.1037/a0026135 [doi]
PST - ppublish
SO  - Prof Psychol Res Pr. 2011 Dec;42(6):543-549. doi: 10.1037/a0026135.


PMID- 22244625
OWN - NLM
STAT- MEDLINE
DCOM- 20120621
LR  - 20151119
IS  - 1878-3554 (Electronic)
IS  - 0099-2399 (Linking)
VI  - 38
IP  - 2
DP  - 2012 Feb
TI  - A survey of dental residents' expectations for regenerative endodontics.
PG  - 137-43
LID - 10.1016/j.joen.2011.10.028 [doi]
AB  - INTRODUCTION: The objective was to survey a group of dental residents regarding
      their expectations for using regenerative endodontic procedures as part of future
      dental treatments. METHODS: After institutional review board approval, the
      opinions of 32 dentists who were having postgraduate residency training to become
      specialists in a dental school were surveyed. The survey had 40 questions about
      professional status, ethical beliefs, judgment, and clinical practice. RESULTS:
      It was found that 83.9% of dentists had no continuing education or training in
      stem cells or regenerative endodontic procedures. Results showed that 96.8% of
      dentists are willing to receive training to be able to provide regenerative
      endodontic procedures for their patients. Of the total group, 49.1% of dentists
      already use membranes, scaffolds, or bioactive materials to provide dental
      treatment. It was determined that 47.3% of dentists agree that the costs of
      regenerative procedures should be comparable with current treatments. It was also
      found that 55.1% of dentists were unsure whether regenerative procedures would be
      successful. CONCLUSIONS: Dentists are supportive of using regenerative endodontic
      procedures in their dental practice, and they are willing to undergo extra
      training and to buy new technology to provide new procedures. Nevertheless,
      dentists also need more evidence for the effectiveness and safety of regenerative
      treatments before they will be recommended for most patients.
CI  - Copyright (c) 2012. Published by Elsevier Inc.
FAU - Manguno, Christine
AU  - Manguno C
AD  - Department of Endodontics, College of Dental Medicine, Nova Southeastern
      University, Fort Lauderdale, Florida, USA.
FAU - Murray, Peter E
AU  - Murray PE
FAU - Howard, Cameron
AU  - Howard C
FAU - Madras, Jonathan
AU  - Madras J
FAU - Mangan, Stephen
AU  - Mangan S
FAU - Namerow, Kenneth N
AU  - Namerow KN
LA  - eng
PT  - Journal Article
DEP - 20111207
PL  - United States
TA  - J Endod
JT  - Journal of endodontics
JID - 7511484
RN  - 0 (Biocompatible Materials)
RN  - 0 (Membranes, Artificial)
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Biocompatible Materials/therapeutic use
MH  - Endodontics/*education/ethics
MH  - Ethics, Dental
MH  - Female
MH  - Humans
MH  - *Internship and Residency
MH  - Male
MH  - Membranes, Artificial
MH  - Middle Aged
MH  - Patient Safety
MH  - Periodicals as Topic
MH  - Practice Patterns, Dentists'
MH  - Professional Practice
MH  - Professional Practice Location
MH  - Regeneration/physiology
MH  - Regenerative Medicine/*education/ethics
MH  - Reimbursement Mechanisms
MH  - Specialties, Dental/*education
MH  - Stem Cells/physiology
MH  - Tissue Engineering
MH  - Tissue Scaffolds
EDAT- 2012/01/17 06:00
MHDA- 2012/06/22 06:00
CRDT- 2012/01/17 06:00
PHST- 2010/11/18 00:00 [received]
PHST- 2011/10/20 00:00 [revised]
PHST- 2011/10/26 00:00 [accepted]
PHST- 2012/01/17 06:00 [entrez]
PHST- 2012/01/17 06:00 [pubmed]
PHST- 2012/06/22 06:00 [medline]
AID - S0099-2399(11)01246-5 [pii]
AID - 10.1016/j.joen.2011.10.028 [doi]
PST - ppublish
SO  - J Endod. 2012 Feb;38(2):137-43. doi: 10.1016/j.joen.2011.10.028. Epub 2011 Dec 7.


PMID- 22242103
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120827
LR  - 20211021
IS  - 1863-5245 (Electronic)
IS  - 1863-5245 (Linking)
VI  - 6
IP  - 1
DP  - 2011
TI  - HIC@RE ... and its relevance for a company like RIEMSER.
PG  - Doc22
LID - 10.3205/dgkh000179 [doi]
AB  - The increased incidence of infections caused by methicillin-resistant strains of 
      Staphylococcus aureus (MRSA) burdens the healthcare systems with significant
      additional costs. Simple measures such as active MRSA screening can lead to a
      reduction of infectious events and massive savings. To establish an effective and
      comprehensive strategy for prevention and eradication of MRSA, the cooperation
      and networking of all stakeholders in the health care system is necessary.
      Pharmaceutical companies are part of the health care system; they therefore have 
      a vital and ethical interest that care within the health system will be further
      optimized and thus continue to remain affordable. The targets of the HIC@RE
      project demonstrate the interests of the pharmaceutical and health-care research 
      company RIEMSER Arzneimittel AG, so that a sufficient rationale is given for
      cooperation in this project.
FAU - Muller, Berno
AU  - Muller B
AD  - RIEMSER Arzneimittel AG, Medical Science & Operations, Greifswald - Insel Riems, 
      Germany.
FAU - Becker, Jurgen
AU  - Becker J
LA  - eng
PT  - Journal Article
DEP - 20111215
PL  - Germany
TA  - GMS Krankenhhyg Interdiszip
JT  - GMS Krankenhaushygiene interdisziplinar
JID - 101313359
PMC - PMC3252645
OTO - NOTNLM
OT  - MRSA
OT  - cost
OT  - economical burden
OT  - multi-resistance
OT  - prevention
OT  - s. aureus
OT  - screening
EDAT- 2012/01/14 06:00
MHDA- 2012/01/14 06:01
CRDT- 2012/01/14 06:00
PHST- 2012/01/14 06:00 [entrez]
PHST- 2012/01/14 06:00 [pubmed]
PHST- 2012/01/14 06:01 [medline]
AID - 10.3205/dgkh000179 [doi]
AID - dgkh000179 [pii]
PST - ppublish
SO  - GMS Krankenhhyg Interdiszip. 2011;6(1):Doc22. doi: 10.3205/dgkh000179. Epub 2011 
      Dec 15.


PMID- 22241267
OWN - NLM
STAT- MEDLINE
DCOM- 20120521
LR  - 20120113
IS  - 1726-4642 (Electronic)
IS  - 1726-4634 (Linking)
VI  - 28
IP  - 4
DP  - 2011 Dec
TI  - [Progress and challenges of clinical trials registration in Latin America and the
      Caribbean's].
PG  - 676-81
LID - S1726-46342011000400017 [pii]
AB  - Clinical trial registries are one of the main sources of information concerning
      health research interventions that have been or are being carried out throughout 
      the world. The World Health Organization (WHO) established a minimum data set to 
      be recorded (20 items), which was agreed upon internationally with the
      stakeholders, and established a network of primary and associated records. In
      addition to the register ClinicalTrial.Gov (of the United States of America),
      there are currently two primary registries in the Americas (from Brazil and Cuba)
      that meet WHO requirements and provide data to WHO's International Clinical
      Trials Registry Platform (ICTRP). Furthermore, there are important advances in
      the region related to the regulations, development and implementation of national
      registries and to the support of the ethics committees and editors to this
      initiative.
FAU - Reveiz, Ludovic
AU  - Reveiz L
AD  - Politicas Publicas e Investigacion en Salud, Sistemas de Salud Basados en
      Atencion Primaria de la Salud, Organizacion Panamericana de la Salud, Washington 
      DC, USA. reveizl@paho.org
FAU - Saenz, Carla
AU  - Saenz C
FAU - Murasaki, Renato T
AU  - Murasaki RT
FAU - Cuervo, Luis G
AU  - Cuervo LG
FAU - Ramalho, Luciano
AU  - Ramalho L
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Avances y retos en el registro de ensayos clinicos en America Latina y el Caribe.
PL  - Peru
TA  - Rev Peru Med Exp Salud Publica
JT  - Revista peruana de medicina experimental y salud publica
JID - 101227566
SB  - IM
MH  - Caribbean Region
MH  - Clinical Trials as Topic/*standards
MH  - Humans
MH  - Latin America
MH  - *Patient Selection
EDAT- 2012/01/14 06:00
MHDA- 2012/05/23 06:00
CRDT- 2012/01/14 06:00
PHST- 2012/01/14 06:00 [entrez]
PHST- 2012/01/14 06:00 [pubmed]
PHST- 2012/05/23 06:00 [medline]
AID - S1726-46342011000400017 [pii]
PST - ppublish
SO  - Rev Peru Med Exp Salud Publica. 2011 Dec;28(4):676-81.


PMID- 22241266
OWN - NLM
STAT- MEDLINE
DCOM- 20120521
LR  - 20191112
IS  - 1726-4642 (Electronic)
IS  - 1726-4634 (Linking)
VI  - 28
IP  - 4
DP  - 2011 Dec
TI  - [Ethics and medicine: the experience of the Peruvian Medical Association].
PG  - 670-5
LID - S1726-46342011000400016 [pii]
AB  - This article shows the work of the Peruvian Medical Association with respect to
      ethical disciplinary procedures, but also shows how, beyond the ethical control, 
      the Order has promoted through a set of actions, a technically competent health
      care that respects the dignity and fundamental human rights. Part of these
      actions are the establishment of the Patient's Day, the emphasis in improving the
      quality and safety in the care of the users of the health services, the
      initiative to prevent and treat adverse events, the regulation and improvement of
      the physicians training both in pre as in post-graduate levels, and the demand
      for the establishment of an optimal health system and policies that will realize 
      the right to health in the context of the principles of bioethics.
FAU - Mendoza F, Alfonso
AU  - Mendoza F A
AD  - Comite de Vigilancia Etica y Deontologica, Consejo Nacional, Colegio Medico del
      Peru, Lima, Peru. alfonsomendozaf@yahoo.com
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Etica y medicina: la experiencia del Colegio Medico del Peru
PL  - Peru
TA  - Rev Peru Med Exp Salud Publica
JT  - Revista peruana de medicina experimental y salud publica
JID - 101227566
SB  - IM
MH  - Bioethics/education
MH  - *Ethics, Medical/education
MH  - Humans
MH  - Peru
MH  - *Societies, Medical
EDAT- 2012/01/14 06:00
MHDA- 2012/05/23 06:00
CRDT- 2012/01/14 06:00
PHST- 2012/01/14 06:00 [entrez]
PHST- 2012/01/14 06:00 [pubmed]
PHST- 2012/05/23 06:00 [medline]
AID - S1726-46342011000400016 [pii]
AID - 10.1590/s1726-46342011000400016 [doi]
PST - ppublish
SO  - Rev Peru Med Exp Salud Publica. 2011 Dec;28(4):670-5. doi:
      10.1590/s1726-46342011000400016.


PMID- 22241265
OWN - NLM
STAT- MEDLINE
DCOM- 20120521
LR  - 20191112
IS  - 1726-4642 (Electronic)
IS  - 1726-4634 (Linking)
VI  - 28
IP  - 4
DP  - 2011 Dec
TI  - [Ethics and investigation].
PG  - 664-9
LID - S1726-46342011000400015 [pii]
AB  - The authors make a critical evaluation of the ethical aspects of research based
      on their experience as university teachers and members of Ethics Committees. They
      invite to the discussion on topics that they consider polemic. They begin by
      mentioning the regulatory role of the International and Local Ethical Norms and
      of the Ethics Committees. They comment on the position of South American
      bioethicists regarding the so-called ethical "double standard" and on the
      liberalization of the use of the placebo. They criticize the damage that the
      system of patents causes on low- resources patients, as well as the lack of
      interest in the development of new medications to treat neglected diseases or
      those diseases which are only prevalent in poor countries, and the excessive
      length of the Informed Consents. They finish giving their opinion about the
      distribution of the clinical trials among the researchers, the problems that
      affect the Ethics Committees and some contents of the Regulation of Clinical
      Trials of the National Institute of Health.
FAU - Zavala, Salomon
AU  - Zavala S
AD  - Instituto de Etica en Salud, Universidad Nacional Mayor de San Marcos, Lima,
      Peru.
FAU - Alfaro-Mantilla, Julio
AU  - Alfaro-Mantilla J
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Etica e investigacion.
PL  - Peru
TA  - Rev Peru Med Exp Salud Publica
JT  - Revista peruana de medicina experimental y salud publica
JID - 101227566
SB  - IM
CIN - Rev Peru Med Exp Salud Publica. 2012 Mar;29(1):149-51; author reply 154-5. PMID: 
      22510922
CIN - Rev Peru Med Exp Salud Publica. 2012 Mar;29(1):151-3; author reply 154-5. PMID:
      22510923
CIN - Rev Peru Med Exp Salud Publica. 2012 Mar;29(1):153-4; author reply 154-5. PMID:
      22510924
MH  - Bioethics
MH  - *Ethics, Research
MH  - Human Experimentation
MH  - Humans
MH  - Informed Consent
EDAT- 2012/01/14 06:00
MHDA- 2012/05/23 06:00
CRDT- 2012/01/14 06:00
PHST- 2012/01/14 06:00 [entrez]
PHST- 2012/01/14 06:00 [pubmed]
PHST- 2012/05/23 06:00 [medline]
AID - S1726-46342011000400015 [pii]
AID - 10.1590/s1726-46342011000400015 [doi]
PST - ppublish
SO  - Rev Peru Med Exp Salud Publica. 2011 Dec;28(4):664-9. doi:
      10.1590/s1726-46342011000400015.


PMID- 22241251
OWN - NLM
STAT- MEDLINE
DCOM- 20120521
LR  - 20120113
IS  - 1726-4642 (Electronic)
IS  - 1726-4634 (Linking)
VI  - 28
IP  - 4
DP  - 2011 Dec
TI  - [Ethics, bioethics and medicine].
PG  - 578-80
LID - S1726-46342011000400001 [pii]
FAU - Perales, Alberto
AU  - Perales A
LA  - spa
PT  - Editorial
TT  - Etica, bioetica y medicina.
PL  - Peru
TA  - Rev Peru Med Exp Salud Publica
JT  - Revista peruana de medicina experimental y salud publica
JID - 101227566
SB  - IM
MH  - *Bioethics
MH  - *Ethics, Medical
EDAT- 2012/01/14 06:00
MHDA- 2012/05/23 06:00
CRDT- 2012/01/14 06:00
PHST- 2012/01/14 06:00 [entrez]
PHST- 2012/01/14 06:00 [pubmed]
PHST- 2012/05/23 06:00 [medline]
AID - S1726-46342011000400001 [pii]
PST - ppublish
SO  - Rev Peru Med Exp Salud Publica. 2011 Dec;28(4):578-80.


PMID- 22241202
OWN - NLM
STAT- MEDLINE
DCOM- 20120301
LR  - 20190911
IS  - 0080-6234 (Print)
IS  - 0080-6234 (Linking)
VI  - 45
IP  - 6
DP  - 2011 Dec
TI  - [Social representations of caring and treating: the look of patients and
      professionals].
PG  - 1427-33
LID - S0080-62342011000600021 [pii]
AB  - The objective of this study was to learn about the central nucleus of the social 
      representations of caring and treating for patients and nurses. This qualitative 
      study was founded on the theoretical-methodological framework of the structural
      approach of social representations. Participants were 90 subjects, who answered a
      questionnaire using the free association technique. Data analysis was performed
      using Evoc software. Results show that the social representations that patients
      and professionals have of the concepts of caring express an ethical, sensitive,
      solidary, affective and committed relationship with a loving human life. However,
      the representations of treating point at different meanings and different
      expectations. In conclusion, the difference between these representations is
      rather concerning and deserves special attention. Such discrepancy denounces that
      the service that the professionals have delivered does not meat the demand and
      desires of patients.
FAU - Borges, Moema da Silva
AU  - Borges Mda S
AD  - Departamento de Enfermagem, Universidade de Brasilia, Brasilia, DF, Brasil.
      mborges@unb.br
FAU - Queiroz, Lilian Silva
AU  - Queiroz LS
FAU - da Silva, Hellen Cristina Pereira
AU  - da Silva HC
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Representacoes sociais sobre cuidar e tratar: o olhar de pacientes e
      profissionais.
PL  - Brazil
TA  - Rev Esc Enferm USP
JT  - Revista da Escola de Enfermagem da U S P
JID - 0242726
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Nurses
MH  - Nursing/*standards
MH  - *Patients
MH  - Sociology
MH  - Young Adult
EDAT- 2012/01/14 06:00
MHDA- 2012/03/02 06:00
CRDT- 2012/01/14 06:00
PHST- 2010/02/28 00:00 [received]
PHST- 2011/03/09 00:00 [accepted]
PHST- 2012/01/14 06:00 [entrez]
PHST- 2012/01/14 06:00 [pubmed]
PHST- 2012/03/02 06:00 [medline]
AID - S0080-62342011000600021 [pii]
AID - 10.1590/s0080-62342011000600021 [doi]
PST - ppublish
SO  - Rev Esc Enferm USP. 2011 Dec;45(6):1427-33. doi: 10.1590/s0080-62342011000600021.


PMID- 22240740
OWN - NLM
STAT- MEDLINE
DCOM- 20120214
LR  - 20181201
IS  - 1357-6321 (Print)
IS  - 1357-6321 (Linking)
VI  - 17
IP  - 12
DP  - 2011 Dec
TI  - Challenges that specialist palliative care nurses encounter when caring for
      patients with advanced dementia.
PG  - 587-91
AB  - Specialist palliative care (SPC) has expanded recently in Ireland to incorporate 
      diseases other than cancer, including dementia. Two care areas that pose specific
      challenges for SPC nurses when caring for people with advanced dementia are pain 
      and nutrition/hydration. Assessment and management of pain for a patient who has 
      advanced dementia differs greatly from that for a typical palliative care
      patient. Similarly, nutrition and hydration pose extraordinary ethical and
      practical dilemmas not encountered when caring for a patient without dementia.
      This paper reports a literature review which revealed that although
      evidence-based information related to each of these areas is available, it tends 
      to be written from the perspective of health professionals with an interest in
      dementia rather than from the perspective of the SPC nurse. SPC nurses require
      evidence-based palliative care research to guide their practice, but such
      research appears to be limited for patients with advanced dementia. Knowledge
      from specialists in both dementia care and palliative care needs to be combined
      if we are to provide these patients with the best possible end-of-life care.
      Further research is required and evidenced-based guidelines need to be
      formulated.
FAU - Barber, Jean
AU  - Barber J
AD  - St. Michael's Hospital, Dun Laoghaire, County Dublin, Ireland.
      j.barber@stmichaels.ie
FAU - Murphy, Kathleen
AU  - Murphy K
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Int J Palliat Nurs
JT  - International journal of palliative nursing
JID - 9506762
MH  - Aged
MH  - Aged, 80 and over
MH  - Dehydration/complications/prevention & control
MH  - Dementia/complications/*nursing
MH  - Humans
MH  - *Nurses
MH  - Nutritional Status
MH  - Pain Management
MH  - *Palliative Care
MH  - *Specialties, Nursing
MH  - Workforce
EDAT- 2012/01/14 06:00
MHDA- 2012/02/15 06:00
CRDT- 2012/01/14 06:00
PHST- 2012/01/14 06:00 [entrez]
PHST- 2012/01/14 06:00 [pubmed]
PHST- 2012/02/15 06:00 [medline]
AID - 10.12968/ijpn.2011.17.12.587 [doi]
PST - ppublish
SO  - Int J Palliat Nurs. 2011 Dec;17(12):587-91. doi: 10.12968/ijpn.2011.17.12.587.


PMID- 22239047
OWN - NLM
STAT- MEDLINE
DCOM- 20120207
LR  - 20161125
IS  - 0954-7762 (Print)
IS  - 0954-7762 (Linking)
VI  - 107
IP  - 49-50
DP  - 2011 Dec 13-2012 Jan 9
TI  - Developing evidence-based practice among students.
PG  - 21-3
AB  - In response to government initiatives and the rise in patient empowerment, nurses
      are increasingly being challenged to deliver high-quality care supported by
      evidence-based practice. This can be a challenge for nurse educators providing
      the foundation for pre-registration student nurses. Evidence-based practice
      within nursing is achieved by developing and supporting patient-centred
      approaches to care using the most current evidence. This facilitates the
      development of a questioning approach incorporating the four principles of
      healthcare ethics--beneficence, non-maleficence, autonomy and justice.
FAU - Emanuel, Vernel
AU  - Emanuel V
AD  - School of Health and Wellbeing, University of Wolverhampton.
FAU - Day, Karen
AU  - Day K
FAU - Diegnan, Lorraine
AU  - Diegnan L
FAU - Pryce-Miller, Maxine
AU  - Pryce-Miller M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Times
JT  - Nursing times
JID - 0423236
MH  - *Education, Nursing
MH  - Evidence-Based Nursing/*education
MH  - Humans
MH  - *Patient-Centered Care
MH  - United Kingdom
EDAT- 2012/01/14 06:00
MHDA- 2012/02/09 06:00
CRDT- 2012/01/14 06:00
PHST- 2012/01/14 06:00 [entrez]
PHST- 2012/01/14 06:00 [pubmed]
PHST- 2012/02/09 06:00 [medline]
PST - ppublish
SO  - Nurs Times. 2011 Dec 13-2012 Jan 9;107(49-50):21-3.


PMID- 22238913
OWN - NLM
STAT- MEDLINE
DCOM- 20120301
LR  - 20191112
IS  - 1145-0762 (Print)
IS  - 1145-0762 (Linking)
VI  - 22
IP  - 3-4
DP  - 2011 Sep-Dec
TI  - Cognitive enhancement, human evolution and bioethics.
PG  - 153-73, 199
AB  - The goal of this article are three-fold. The first is to explore the relations
      between the properties designated by the terms "human", "post-human,"
      "Transhuman", and to clarify the corresponding "isms". The second is to
      scrutinize the current techniques for cognitive enhancement in order to assess
      their relations with the three categories just mentioned, and, with the specific 
      ethical issues that they are raising. The third is to examine whether general
      ethical principles could be invoked either in favor of or against, the normative 
      proposals of post- and trans-humanism, and to consider how compatible the types
      of enhancement presently developed are with respect to these principles.
FAU - Proust, Joelle
AU  - Proust J
AD  - Institut Jean-Nicod, Ecole Normale Superieure, Paris. jproust@ehess.fr
LA  - eng
PT  - Journal Article
PL  - France
TA  - J Int Bioethique
JT  - Journal international de bioethique = International journal of bioethics
JID - 9015754
SB  - IM
MH  - *Biological Evolution
MH  - Biomedical Enhancement/*ethics
MH  - Bionics
MH  - *Cognition
MH  - Humans
EDAT- 2012/01/14 06:00
MHDA- 2012/03/02 06:00
CRDT- 2012/01/14 06:00
PHST- 2012/01/14 06:00 [entrez]
PHST- 2012/01/14 06:00 [pubmed]
PHST- 2012/03/02 06:00 [medline]
AID - 10.3917/jib.222.0153 [doi]
PST - ppublish
SO  - J Int Bioethique. 2011 Sep-Dec;22(3-4):153-73, 199. doi: 10.3917/jib.222.0153.


PMID- 22238912
OWN - NLM
STAT- MEDLINE
DCOM- 20120301
LR  - 20120113
IS  - 1145-0762 (Print)
IS  - 1145-0762 (Linking)
VI  - 22
IP  - 3-4
DP  - 2011 Sep-Dec
TI  - [Enhancement and ethics].
PG  - 137-51, 198-9
AB  - Now suppose we could use genetic engineering, regenerative medicine or drugs
      --chemical enhancers, or reproductive technology or nanotechnology to produce
      healthier, fitter and more intelligent individuals, what should our reaction be? 
      Would it be unethical to do so? Would it be ethical not to do so? Our question is
      this: If the goal of enhanced intelligence, increased powers and capacities and
      better health is something that we might strive to produce through education,
      including of course the more general health education of the community; why
      should we not produce these goals, if we can do so safely, through enhancement
      technologies or procedures? If these are legitimate aims of education could they 
      be illegitimate as the aims of medical or life science, as opposed to educational
      science?
FAU - Harris, John
AU  - Harris J
AD  - L'Institute for Science, Ethics and Innovation, Manchester, U.K.
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - "Enhancement" et ethique.
PL  - France
TA  - J Int Bioethique
JT  - Journal international de bioethique = International journal of bioethics
JID - 9015754
SB  - IM
MH  - Biomedical Enhancement/*ethics
MH  - Humans
EDAT- 2012/01/14 06:00
MHDA- 2012/03/02 06:00
CRDT- 2012/01/14 06:00
PHST- 2012/01/14 06:00 [entrez]
PHST- 2012/01/14 06:00 [pubmed]
PHST- 2012/03/02 06:00 [medline]
PST - ppublish
SO  - J Int Bioethique. 2011 Sep-Dec;22(3-4):137-51, 198-9.


PMID- 22238911
OWN - NLM
STAT- MEDLINE
DCOM- 20120301
LR  - 20191112
IS  - 1145-0762 (Print)
IS  - 1145-0762 (Linking)
VI  - 22
IP  - 3-4
DP  - 2011 Sep-Dec
TI  - [Bodily excellence and education: ambiguities of performance].
PG  - 123-34, 197-8
AB  - The notion of excellence contains an ambivalence: to aim at the "good" and/or to 
      aim at the "best". This ambivalence exists particularly in the physical effort
      and in the history of bodily practices, shared between gymnastics, physical
      education and sports. In the second part of the XXth century, the notion of
      performance became "worship of performance", "infinite perfectibility". In this
      context, high level sports became the human improvement laboratory, thanks to the
      sophistication of its technical means and the its practices intensity. However
      this "high" questions: about physical and psychological consequences of intensive
      practices ; about doping and its medical and ethical perspectives; about the
      increasing precociousness and the potential exploitation of the baby champions.
      It questions about the nature of familial, social, economical norms transmitted
      by education: about articulation between constraint and self-government. This is 
      the question about the "price" of excellence. In this sense it appears that the
      excellence of champion spreads out the margins of an ethics which would be meant 
      to be regulating and universal, indeed this excellence is perhaps, in the same
      capacity as genius is and in spite of the attachment of sports to a "ethics of
      the rule", un-ethical.
FAU - Queval, Isabelle
AU  - Queval I
AD  - Universite Paris Descartes, Sorbonne Paris Cite, 45 rue des Saints-Peres, 75006
      Paris. iqueval@orange.fr
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Excellence corporelle et education: les ambiguites de la performance.
PL  - France
TA  - J Int Bioethique
JT  - Journal international de bioethique = International journal of bioethics
JID - 9015754
SB  - IM
MH  - *Athletes
MH  - *Athletic Performance/ethics
MH  - Humans
MH  - Physical Education and Training
EDAT- 2012/01/14 06:00
MHDA- 2012/03/02 06:00
CRDT- 2012/01/14 06:00
PHST- 2012/01/14 06:00 [entrez]
PHST- 2012/01/14 06:00 [pubmed]
PHST- 2012/03/02 06:00 [medline]
AID - 10.3917/jib.222.0123 [doi]
PST - ppublish
SO  - J Int Bioethique. 2011 Sep-Dec;22(3-4):123-34, 197-8. doi: 10.3917/jib.222.0123.


PMID- 22238910
OWN - NLM
STAT- MEDLINE
DCOM- 20120301
LR  - 20191112
IS  - 1145-0762 (Print)
IS  - 1145-0762 (Linking)
VI  - 22
IP  - 3-4
DP  - 2011 Sep-Dec
TI  - [Doping in sport and enhancement medicine].
PG  - 93-121, 196-7
AB  - The reason that gives doping in sport a deeper philosophical and ethical
      dimension is the emergence of a new medical paradigm: enhancement medicine. The
      question of enhancing performance in sport has become part of a broader societal 
      debate on human enhancement. The gradual blurriness of the boarders between
      therapeutic medicine and enhancement medicine constitutes the most spectacular
      and the most troublesome form of these modifications. In the contemporary
      biomedicine, the new medicines and technologies can be used not only to cure the 
      patients but also to enhance human capacities. This evolution represents a
      paradigmatic change in the medical practice: it is not the mere restoration of
      health which is expected anymore, nor the promotion of health. What is required
      is the improvement of performance and the perfectibility of the human being,
      including in the field of sport. Competitive sport could become the main
      laboratory of enhancement medicine. The intersection of science and sport raises 
      fundamental philosophical, ethical and policy issues that cannot be answered
      easily. The prohibition and the war on doping is not the only solution.
FAU - Missa, Jean-Noel
AU  - Missa JN
AD  - Recherche Scientifique & Universite Libre de Bruxelles. jmissa@ulb.ac.be
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Dopage sportif et medecine d'amelioration.
PL  - France
TA  - J Int Bioethique
JT  - Journal international de bioethique = International journal of bioethics
JID - 9015754
SB  - IM
MH  - Athletic Performance
MH  - Biomedical Enhancement/*ethics
MH  - Doping in Sports/*ethics
MH  - Genetic Therapy
MH  - Humans
EDAT- 2012/01/14 06:00
MHDA- 2012/03/02 06:00
CRDT- 2012/01/14 06:00
PHST- 2012/01/14 06:00 [entrez]
PHST- 2012/01/14 06:00 [pubmed]
PHST- 2012/03/02 06:00 [medline]
AID - 10.3917/jib.222.0093 [doi]
PST - ppublish
SO  - J Int Bioethique. 2011 Sep-Dec;22(3-4):93-121, 196-7. doi: 10.3917/jib.222.0093.


PMID- 22238906
OWN - NLM
STAT- MEDLINE
DCOM- 20120301
LR  - 20191112
IS  - 1145-0762 (Print)
IS  - 1145-0762 (Linking)
VI  - 22
IP  - 3-4
DP  - 2011 Sep-Dec
TI  - [Human technical enhancement: an introduction to the currents of the debate as
      well as their fracture lines].
PG  - 33-50, 192
AB  - The main objective of this article is to suggest a panel of the different
      positions active in the human enhancement's debate, to analyze their arguments
      and to point out the dividing zones. The transhumanist movement is therefore
      presented in order to highlight the principal thematic of its philosophy, its
      means of action and the plurality of its subgroups. The purpose is to reassess
      its complexity in an introductory manner far from the usual, excessive
      simplifications. In a second time, the "bioconservative" movement is also
      examined in its foundations to emphasize the norms and principles that are
      undoubtedly shared by the opponents to the human being's modification. Then, the 
      thinkers of the "liberal ethics" are exemplified as a more moderate alternative, 
      although not flawless. Generally open-minded towards the application of
      enhancement technologies, they protect as an ultimate guardian, the harm
      principle, as well as the absolute respect of individual freedom. Once the
      protagonists are introduced, the true meaning of these positions is replaced in
      the context of the three main fracture lines: the human nature, the normality
      criterion and the equality principle. A complex debate indeed that we could
      summarize by a simple question: what will human do about the human in the 21st
      century?
FAU - Frippiat, Laurent
AU  - Frippiat L
AD  - Universite Libre de Bruxelles. laurent.frippiat@ulb.ac.be
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - L'amelioration technique de l'etre humain: introduction aux differents courants
      du debat.
PL  - France
TA  - J Int Bioethique
JT  - Journal international de bioethique = International journal of bioethics
JID - 9015754
SB  - IM
MH  - Biomedical Enhancement/*ethics
MH  - *Human Characteristics
MH  - Humans
MH  - *Philosophy
EDAT- 2012/01/14 06:00
MHDA- 2012/03/02 06:00
CRDT- 2012/01/14 06:00
PHST- 2012/01/14 06:00 [entrez]
PHST- 2012/01/14 06:00 [pubmed]
PHST- 2012/03/02 06:00 [medline]
AID - 10.3917/jib.222.0033 [doi]
PST - ppublish
SO  - J Int Bioethique. 2011 Sep-Dec;22(3-4):33-50, 192. doi: 10.3917/jib.222.0033.


PMID- 22238836
OWN - NLM
STAT- MEDLINE
DCOM- 20120207
LR  - 20170214
IS  - 0091-2174 (Print)
IS  - 0091-2174 (Linking)
VI  - 41
IP  - 4
DP  - 2011
TI  - A psychosocial evaluation process for living liver donors: the University of
      Rochester model.
PG  - 295-308
AB  - OBJECTIVE: The donation of livers by living donors entails complex processes,
      both surgically and psychosocially, potentially involving risks in both domains. 
      Thorough psychosocial evaluation is necessary to minimize those risks, yet little
      has been written about the donor assessment process. This article describes one
      such process, utilized by a transplant program in upstate New York. METHOD: Donor
      candidates undergo multiple psychosocial interviews early in the overall
      transplant evaluation process. Evaluators subsequently meet as a group, along
      with an independent ethicist, to determine psychosocial candidacy prior to final 
      medical/surgical clearance. RESULTS: Between 2003 and 2007, 416 donor candidates 
      initiated and/or underwent full evaluation, resulting in a 17.5% surgery and
      55.5% exclusion rate among those individuals. Of those ruled out, 20.8% were for 
      (medical or psychosocial) reasons associated with the recipient, and 8.7% were
      for donor-related psychosocial issues. CONCLUSION: Given the primacy
      ofpsychosocial and ethical issues in living liver donor candidate evaluation, the
      multiple interview process, followed by team discussion and overseen by an
      ethicist removed from other transplant program functions, has advantages as a
      donor assessment model.
FAU - Nickels, M W
AU  - Nickels MW
AD  - Department of Psychiatry, University of Rochester Medical Center, Rochester, New 
      York 14642, USA. mark_nickels@urmc.rochester.edu
FAU - Cullen, J P
AU  - Cullen JP
FAU - Demme, R A
AU  - Demme RA
FAU - Vetter, M
AU  - Vetter M
FAU - Boulay, R
AU  - Boulay R
FAU - Betts, R
AU  - Betts R
FAU - McKee, M
AU  - McKee M
FAU - Orloff, M
AU  - Orloff M
FAU - Bozorgzadeh, A
AU  - Bozorgzadeh A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Int J Psychiatry Med
JT  - International journal of psychiatry in medicine
JID - 0365646
SB  - IM
MH  - Adult
MH  - Cooperative Behavior
MH  - Eligibility Determination/ethics
MH  - Ethics, Medical
MH  - Family/psychology
MH  - Female
MH  - Hospitals, University
MH  - Humans
MH  - Interdisciplinary Communication
MH  - Liver Transplantation/ethics/*psychology
MH  - Living Donors/ethics/*psychology
MH  - Male
MH  - Mass Screening/ethics/*psychology
MH  - Mental Disorders/diagnosis/psychology
MH  - Middle Aged
MH  - New York
MH  - Patient Care Team
MH  - Personality Assessment/*statistics & numerical data
EDAT- 2012/01/14 06:00
MHDA- 2012/02/09 06:00
CRDT- 2012/01/14 06:00
PHST- 2012/01/14 06:00 [entrez]
PHST- 2012/01/14 06:00 [pubmed]
PHST- 2012/02/09 06:00 [medline]
AID - 10.2190/PM.41.4.a [doi]
PST - ppublish
SO  - Int J Psychiatry Med. 2011;41(4):295-308. doi: 10.2190/PM.41.4.a.


PMID- 22238782
OWN - NLM
STAT- MEDLINE
DCOM- 20120816
LR  - 20211021
IS  - 1879-0046 (Electronic)
IS  - 0376-8716 (Linking)
VI  - 119
IP  - 3
DP  - 2011 Dec 15
TI  - Collegial ethics: what, why and how.
PG  - 235-8
AB  - Collegial ethics (CE) proposes that we support our colleagues whenever possible. 
      It is more of a focus on the feelings of others rather than on our own. In spite 
      of the importance of collegial interactions, CE is not usually taught. Courses in
      CE need to be developed, and collegial skills need to be identified, taught and
      practiced. Such skills would include: use of the golden rule, supportive
      communication, conflict resolution, and even the development of greater courage
      in our actions.
FAU - Kuhar, Michael J
AU  - Kuhar MJ
AD  - Yerkes National Primate Research Center of Emory University, 954 Gatewood Rd, NE,
      Atlanta, GA 30329, USA. mkuhar@emory.edu
LA  - eng
GR  - R01 DA015162/DA/NIDA NIH HHS/United States
GR  - P51 RR000165/RR/NCRR NIH HHS/United States
GR  - R01 DA010732/DA/NIDA NIH HHS/United States
GR  - T32 DA015040/DA/NIDA NIH HHS/United States
GR  - DA15040/DA/NIDA NIH HHS/United States
GR  - DA15162/DA/NIDA NIH HHS/United States
GR  - RR00165/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - Ireland
TA  - Drug Alcohol Depend
JT  - Drug and alcohol dependence
JID - 7513587
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Communication
MH  - *Cooperative Behavior
MH  - Humans
MH  - Interprofessional Relations/*ethics
MH  - Negotiating/methods
PMC - PMC4427902
MID - NIHMS684433
EDAT- 2012/01/13 06:00
MHDA- 2012/08/17 06:00
CRDT- 2012/01/13 06:00
PHST- 2012/01/13 06:00 [entrez]
PHST- 2012/01/13 06:00 [pubmed]
PHST- 2012/08/17 06:00 [medline]
AID - S0376-8716(11)00466-2 [pii]
AID - 10.1016/j.drugalcdep.2011.10.015 [doi]
PST - ppublish
SO  - Drug Alcohol Depend. 2011 Dec 15;119(3):235-8. doi:
      10.1016/j.drugalcdep.2011.10.015.


PMID- 22237808
OWN - NLM
STAT- MEDLINE
DCOM- 20120517
LR  - 20171213
IS  - 1724-6075 (Electronic)
IS  - 0391-5603 (Linking)
VI  - 78
IP  - 4
DP  - 2011 Oct-Dec
TI  - [Overactive bladder syndrome: the social and economic perspective].
PG  - 241-56
LID - 10.5301/RU.2011.8886 [doi]
AB  - Overactive bladder syndrome (OAB) is a highly prevalent condition associated with
      a significant impairment of patients' Quality of Life (QoL) because of its
      adverse effects on social, sexual, interpersonal, and professional functions.
      Cost-of-illness analyses showed the huge economic burden related to OAB for
      patients, public healthcare systems, and society, secondary to both direct and
      indirect costs. These types of cost analyses, however, exclude intangible costs
      related to QoL impairment. Recently, many novel therapies have been introduced,
      arising the need to apply the modern methodology of Health Technology Assessment 
      (HTA) to new therapies in order to evaluate objectively their value in terms of
      both improvement in length/Quality of Life and costs. By producing information on
      the clinical, economic, organizational, social and ethical impact of health
      technologies, HTA has been used worldwide to inform decision makers at different 
      levels in health systems. The HTA approach demonstrated, worldwide, to be a
      useful approach to increase the level of appropriateness in the use of medical
      technology and, as a consequence of that, of resources. Health utilities are
      instruments that allow a measurement of QoL and its integration in the economic
      evaluation using the Quality-of-life-Adjusted-Life-Years (QALYs) model and
      cost-utility analysis. The development of suitable instruments for quantifying
      utility in the specific group of OAB patients is vitally important to extend the 
      application of cost-utility analysis in OAB and to guide healthcare resources
      allocation for this disorder. Studies are required to define the
      cost-effectiveness of available pharmacological and non-pharmacological therapy
      options.
FAU - Sacco, Emilio
AU  - Sacco E
AD  - Clinica Urologica, Dipartimento di Scienze chirurgiche, Policlinico Agostino
      Gemelli, Universita Cattolica del Sacro Cuore, Roma - Italia.
      emilio.sacco@gmail.com
FAU - Bientinesi, Riccardo
AU  - Bientinesi R
FAU - Marangi, Francesco
AU  - Marangi F
FAU - D'Addessi, Alessandro
AU  - D'Addessi A
FAU - Racioppi, Marco
AU  - Racioppi M
FAU - Gulino, Gaetano
AU  - Gulino G
FAU - Pinto, Francesco
AU  - Pinto F
FAU - Totaro, Angelo
AU  - Totaro A
FAU - Bassi, Pierfrancesco
AU  - Bassi P
LA  - ita
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Sindrome della vescica iperattiva: la prospettiva socioeconomica.
PL  - United States
TA  - Urologia
JT  - Urologia
JID - 0417372
SB  - IM
MH  - Combined Modality Therapy
MH  - Cost of Illness
MH  - Cost-Benefit Analysis
MH  - Drug Costs
MH  - Electric Stimulation Therapy/economics
MH  - Health Expenditures
MH  - Humans
MH  - Models, Theoretical
MH  - Prevalence
MH  - Quality of Life
MH  - Quality-Adjusted Life Years
MH  - Randomized Controlled Trials as Topic
MH  - Severity of Illness Index
MH  - Therapies, Investigational/economics
MH  - *Urinary Bladder, Overactive/economics/epidemiology/psychology/therapy
EDAT- 2012/01/13 06:00
MHDA- 2012/05/18 06:00
CRDT- 2012/01/13 06:00
PHST- 2011/10/25 00:00 [accepted]
PHST- 2012/01/13 06:00 [entrez]
PHST- 2012/01/13 06:00 [pubmed]
PHST- 2012/05/18 06:00 [medline]
AID - AF2EFCA0-2698-4221-BDC7-67B629352287 [pii]
AID - 10.5301/RU.2011.8886 [doi]
PST - ppublish
SO  - Urologia. 2011 Oct-Dec;78(4):241-56. doi: 10.5301/RU.2011.8886.


PMID- 22237442
OWN - NLM
STAT- MEDLINE
DCOM- 20120515
LR  - 20220210
IS  - 1530-0366 (Electronic)
IS  - 1098-3600 (Linking)
VI  - 14
IP  - 1
DP  - 2012 Jan
TI  - Revisiting the Wilson-Jungner criteria: how can supplemental criteria guide
      public health in the era of genetic screening?
PG  - 129-34
LID - 10.1038/gim.0b013e31823331d0 [doi]
AB  - PURPOSE: Advances in technology have made newborn screening for more than 50
      inborn errors of metabolism possible using a dried blood sample. A framework is
      proposed that public health practitioners may use when considering candidate
      disorders for newborn screening panels. METHODS: The framework expands on the 10 
      Wilson-Jungner criteria with the addition of 11 criteria specific to newborn
      screening. A calculation, the "pNBS Decision Score," is used to quantify results 
      and rank candidate disorders. RESULTS: The pNBS Decision Scores that were
      calculated for phenylketonuria (OMIM# 261600), cystic fibrosis (OMIM# 219700),
      Pompe disease (OMIM# 232300), and severe combined immunodeficiency (OMIM# 102700)
      support their inclusion as newborn screening disorders. The pNBS Decision Score
      suggests that Krabbe disease (OMIM# 245200) is not a candidate disorder for
      inclusion at this time. CONCLUSION: The proposed framework adds to the ability of
      policy makers to quantify an essential portion of the process for adding
      disorders to newborn screening panels. Other factors such as ethical, legal, and 
      social issues, clinical utility, and advocacy are also part of the policy
      process. The framework is not intended to replace existing nomination processes
      but rather to enhance those processes by encouraging iterative review of newborn 
      screening-specific criteria. The use of the framework will provide consistency
      across a portion of the decision process. The public health community should take
      the opportunity to revisit the screening determinants of the Wilson-Jungner
      criteria from a 21st century perspective. The results suggest that this framework
      provides the public health practitioner with a consistent process for making an
      evidence-based decision.
FAU - Petros, Michael
AU  - Petros M
AD  - University of Illinois, School of Public Health, Chicago, Illinois, USA.
      Michael.P.Petros@gmail.com
LA  - eng
PT  - Journal Article
DEP - 20111007
PL  - United States
TA  - Genet Med
JT  - Genetics in medicine : official journal of the American College of Medical
      Genetics
JID - 9815831
SB  - IM
MH  - Genetic Diseases, Inborn/diagnosis
MH  - Genetic Testing/legislation & jurisprudence/*standards
MH  - Humans
MH  - Infant, Newborn
MH  - Neonatal Screening/legislation & jurisprudence/*standards
MH  - Public Health/legislation & jurisprudence/*standards
EDAT- 2012/01/13 06:00
MHDA- 2012/05/16 06:00
CRDT- 2012/01/13 06:00
PHST- 2012/01/13 06:00 [entrez]
PHST- 2012/01/13 06:00 [pubmed]
PHST- 2012/05/16 06:00 [medline]
AID - S1098-3600(21)03294-9 [pii]
AID - 10.1038/gim.0b013e31823331d0 [doi]
PST - ppublish
SO  - Genet Med. 2012 Jan;14(1):129-34. doi: 10.1038/gim.0b013e31823331d0. Epub 2011
      Oct 7.


PMID- 22233108
OWN - NLM
STAT- MEDLINE
DCOM- 20120604
LR  - 20120111
IS  - 2044-8287 (Electronic)
IS  - 1359-107X (Linking)
VI  - 17
IP  - 1
DP  - 2012 Feb
TI  - Treatment decision making in breast cancer: a longitudinal exploration of women's
      experiences.
PG  - 155-70
LID - 10.1111/j.2044-8287.2011.02028.x [doi]
AB  - OBJECTIVES: To explore the lived experience of breast cancer in relation to the
      treatment decision-making process over time. DESIGN: Adopting a hermeneutic
      phenomenological approach, semi-structured interviews were undertaken at three
      points in time during the year following diagnosis. METHODS: After ethical
      approval had been obtained, 20 women who were recently diagnosed with breast
      cancer were recruited from a Symptomatic Breast Cancer Unit in the North East of 
      England. RESULTS: Four themes emerged: role in the treatment decision-making
      process; acceptance of medical opinions; getting rid of it; and cancer schemas.
      The majority of women reported a passive role in the surgical treatment
      decision-making process and all women did so in relation to subsequent treatment 
      decisions. However, women adopted this role consciously and consequently were not
      disengaged from the process but maintained a sense of ownership and control over 
      their health. The women did not describe experiencing decisional regret at any
      point in the year following diagnosis and rarely revisited the decisions made,
      only doing so in a positive manner. Trust in the abilities and experience of
      healthcare professionals and maximizing chances of survival were cited as reasons
      for not having had greater involvement. Despite being given information about
      treatment options, many women made the decision not to attend to this information
      perceiving this to be anxiety provoking. CONCLUSIONS: The findings from this
      study suggest a need for eliciting more specific psycho-social interactions in
      the treatment decision-making process in order to identify ways in which women
      can be supported throughout their experience.
CI  - (c)2011 The British Psychological Society.
FAU - Swainston, Katherine
AU  - Swainston K
AD  - School of Social Sciences & Law, University of Teesside, Middlesbrough, UK.
      K.Swainston@tees.ac.uk
FAU - Campbell, Carol
AU  - Campbell C
FAU - van Wersch, Anna
AU  - van Wersch A
FAU - Durning, Patricia
AU  - Durning P
LA  - eng
PT  - Journal Article
DEP - 20110504
PL  - England
TA  - Br J Health Psychol
JT  - British journal of health psychology
JID - 9605409
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Breast Neoplasms/diagnosis/*therapy
MH  - England
MH  - Female
MH  - Humans
MH  - Interviews as Topic
MH  - Longitudinal Studies
MH  - Middle Aged
MH  - *Patient Participation
MH  - Young Adult
EDAT- 2012/01/12 06:00
MHDA- 2012/06/05 06:00
CRDT- 2012/01/12 06:00
PHST- 2012/01/12 06:00 [entrez]
PHST- 2012/01/12 06:00 [pubmed]
PHST- 2012/06/05 06:00 [medline]
AID - 10.1111/j.2044-8287.2011.02028.x [doi]
PST - ppublish
SO  - Br J Health Psychol. 2012 Feb;17(1):155-70. doi:
      10.1111/j.2044-8287.2011.02028.x. Epub 2011 May 4.


PMID- 22232522
OWN - NLM
STAT- MEDLINE
DCOM- 20120229
LR  - 20120110
IS  - 0237-7896 (Print)
IS  - 0237-7896 (Linking)
VI  - 26
IP  - 5
DP  - 2011
TI  - [Psychological aspects of induced abortion].
PG  - 343-9
AB  - The present paper, based on the results of international studies, is focused on
      the reconsideration of the psychological aspects of induced abortion. By
      presenting a narrow cross-section of the Hungarian demographic data, we would
      like to emphasise the necessity and the significance of a deeper understanding of
      the subject. Factors behind the decision-making, short- and long term outcomes of
      the intervention influencing primarily the mental health of women and
      partner-relationship aspects are discussed in details. While acknowledging the
      complexity of the subject deriving from the legal, ethical, moral, religious,
      medical, social and sociological concerns, our aim is to call attention to the
      psychological aspects of induced abortion and the importance of psychological
      care of women undergoing surgical operation.
FAU - Sz Mako, Hajnalka
AU  - Sz Mako H
AD  - Pecsi Tudomanyegyetem, Pszichologia Intezet, Szemelyiseg-, Fejlodes- es Klinikai 
      Pszichologia Tanszek, Pecs. mako.hajnalka@gmail.com
FAU - Veszpremi, Bela
AU  - Veszpremi B
LA  - hun
PT  - English Abstract
PT  - Journal Article
TT  - A muvi abortusz pszichologiai vonatkozasai.
PL  - Hungary
TA  - Psychiatr Hung
JT  - Psychiatria Hungarica : A Magyar Pszichiatriai Tarsasag tudomanyos folyoirata
JID - 9426825
SB  - IM
MH  - Abortion, Induced/*psychology/statistics & numerical data
MH  - *Decision Making
MH  - Female
MH  - Humans
MH  - Hungary/epidemiology
MH  - Pregnancy
MH  - Risk Factors
MH  - Sexual Partners/psychology
MH  - Socioeconomic Factors
MH  - Time Factors
EDAT- 2012/01/11 06:00
MHDA- 2012/03/01 06:00
CRDT- 2012/01/11 06:00
PHST- 2012/01/11 06:00 [entrez]
PHST- 2012/01/11 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
PST - ppublish
SO  - Psychiatr Hung. 2011;26(5):343-9.


PMID- 22229140
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 2231-5004 (Electronic)
IS  - 2229-5151 (Linking)
VI  - 1
IP  - 2
DP  - 2011 Jul
TI  - Palliative critical care in the intensive care unit: A 2011 perspective.
PG  - 147-53
LID - 10.4103/2229-5151.84803 [doi]
AB  - Pain relief and palliative care play an increasingly important role in the
      overall approach to critically ill and injured patients. Despite significant
      progress in clinical patient care, our understanding of death and the dying
      process remains limited. For various reasons, people tend to delay facing
      questions associated with end-of-life, and the fear of the unknown often creates 
      an environment of avoidance and an atmosphere of taboo. The topic of end-of-life 
      care is multifaceted. It incorporates medical, ethical, spiritual, and religious 
      aspects, among many others. Our ability to sustain the lives of the critically
      ill may be complicated by continuing life support in medically futile scenarios. 
      This article, as well as the remainder of the IJCIIS Symposium on End-of-Life in 
      Trauma/Intensive Care Unit, will explore the most important issues in the field
      of modern end-of-life care and palliative medicine, with a focus on critically
      ill and injured patients.
FAU - Adolph, Michael D
AU  - Adolph MD
AD  - Center for Palliative Care, The James Cancer Hospital and Solove Research
      Institute, The Ohio State University Medical Center, Columbus, OH USA.
FAU - Frier, Kimberly A
AU  - Frier KA
FAU - Stawicki, Stanislaw Pa
AU  - Stawicki SP
FAU - Gerlach, Anthony T
AU  - Gerlach AT
FAU - Papadimos, Thomas J
AU  - Papadimos TJ
LA  - eng
PT  - Journal Article
PL  - India
TA  - Int J Crit Illn Inj Sci
JT  - International journal of critical illness and injury science
JID - 101571136
PMC - PMC3249848
OTO - NOTNLM
OT  - Clinical standards
OT  - Intensive care unit
OT  - Latest developments
OT  - Pain and palliative care
EDAT- 2012/01/10 06:00
MHDA- 2012/01/10 06:01
CRDT- 2012/01/10 06:00
PHST- 2012/01/10 06:00 [entrez]
PHST- 2012/01/10 06:00 [pubmed]
PHST- 2012/01/10 06:01 [medline]
AID - 10.4103/2229-5151.84803 [doi]
AID - IJCIIS-1-147 [pii]
PST - ppublish
SO  - Int J Crit Illn Inj Sci. 2011 Jul;1(2):147-53. doi: 10.4103/2229-5151.84803.


PMID- 22229139
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 2231-5004 (Electronic)
IS  - 2229-5151 (Linking)
VI  - 1
IP  - 2
DP  - 2011 Jul
TI  - An overview of end-of-life issues in the intensive care unit.
PG  - 138-46
LID - 10.4103/2229-5151.84801 [doi]
AB  - The population of the earth is aging, and as medical techniques, pharmaceuticals,
      and devices push the boundaries of human physiological capabilities, more humans 
      will go on to live longer. However, this prolonged existence may involve
      incapacities, particularly at the end-of-life, and especially in the intensive
      care unit. This arena involves not only patients and families, but also care
      givers. It involves topics from economics to existentialism, and surgery to
      spiritualism. It requires education, communication, acceptance of diversity, and 
      an ultimate acquiescence to the inevitable. Here, we present a comprehensive
      overview of issues in the care of patients at the end-of-life stage that may
      cause physicians and other healthcare providers, medical, ethical, social, and
      philosophical concerns in the intensive care unit.
FAU - Papadimos, Thomas J
AU  - Papadimos TJ
AD  - Department of Anesthesiology, Division of Critical Care Medicine, The Ohio State 
      University Medical Center, Columbus OH 43210, USA.
FAU - Maldonado, Yasdet
AU  - Maldonado Y
FAU - Tripathi, Ravi S
AU  - Tripathi RS
FAU - Kothari, Deven S
AU  - Kothari DS
FAU - Rosenberg, Andrew L
AU  - Rosenberg AL
LA  - eng
PT  - Journal Article
PL  - India
TA  - Int J Crit Illn Inj Sci
JT  - International journal of critical illness and injury science
JID - 101571136
PMC - PMC3249847
OTO - NOTNLM
OT  - Critical care
OT  - death
OT  - intensive care units
OT  - palliative care
EDAT- 2012/01/10 06:00
MHDA- 2012/01/10 06:01
CRDT- 2012/01/10 06:00
PHST- 2012/01/10 06:00 [entrez]
PHST- 2012/01/10 06:00 [pubmed]
PHST- 2012/01/10 06:01 [medline]
AID - 10.4103/2229-5151.84801 [doi]
AID - IJCIIS-1-138 [pii]
PST - ppublish
SO  - Int J Crit Illn Inj Sci. 2011 Jul;1(2):138-46. doi: 10.4103/2229-5151.84801.


PMID- 22229138
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 2231-5004 (Electronic)
IS  - 2229-5151 (Linking)
VI  - 1
IP  - 2
DP  - 2011 Jul
TI  - Advance directives in the trauma intensive care unit: Do they really matter?
PG  - 132-7
LID - 10.4103/2229-5151.84800 [doi]
AB  - Despite advances in the care of the injured patient, 22% of trauma patients
      admitted to the intensive care unit will die from their injuries. As a majority
      of these deaths will occur due to withdrawal of care, intensivists should be
      proficient in their ability to discuss end-of-life care with patients and
      families. While the use of advance directives to document patients' wishes has
      increased, their utility is uncertain. We review the effectiveness and obstacles 
      of advance directives.
FAU - Gordy, Stephanie
AU  - Gordy S
AD  - Departments of Surgery and Neurology, Oregon Health and Science University, Mail 
      Code L611, 3181 SW Sam Jackson Park, Portland, Oregon 97239, USA.
FAU - Klein, Eran
AU  - Klein E
LA  - eng
PT  - Journal Article
PL  - India
TA  - Int J Crit Illn Inj Sci
JT  - International journal of critical illness and injury science
JID - 101571136
PMC - PMC3249846
OTO - NOTNLM
OT  - Advance directive
OT  - TICU
OT  - critical care
OT  - end-of-life care
OT  - humans
OT  - medical ethics
OT  - palliative care
OT  - trauma
OT  - trauma intensive care
EDAT- 2012/01/10 06:00
MHDA- 2012/01/10 06:01
CRDT- 2012/01/10 06:00
PHST- 2012/01/10 06:00 [entrez]
PHST- 2012/01/10 06:00 [pubmed]
PHST- 2012/01/10 06:01 [medline]
AID - 10.4103/2229-5151.84800 [doi]
AID - IJCIIS-1-132 [pii]
PST - ppublish
SO  - Int J Crit Illn Inj Sci. 2011 Jul;1(2):132-7. doi: 10.4103/2229-5151.84800.


PMID- 22228064
OWN - NLM
STAT- MEDLINE
DCOM- 20120607
LR  - 20220331
IS  - 1556-2654 (Electronic)
IS  - 1556-2646 (Linking)
VI  - 6
IP  - 4
DP  - 2011 Dec
TI  - A multicenter study of the awareness and attitudes of Egyptian faculty towards
      research ethics: a pilot study.
PG  - 99-108
LID - 10.1525/jer.2011.6.4.99 [doi]
AB  - The awareness and attitudes of faculty towards research ethics committees (RECs) 
      and research ethics practices are largely unknown. Accordingly, we conducted a
      cross-sectional survey study involving various faculties (Medicine, Nursing,
      Pharmacy, and Dentistry) from four universities in Egypt. A large majority (>
      85%) held positive attitudes towards RECs, but almost a third thought that RECs
      would delay research. More than half had not received prior training in research 
      or medical ethics, but more than 90% thought that this subject matter should be
      taught to postgraduates. A large majority recognized the need for informed
      consent and confidentiality protections in research, but some held attitudes
      regarding certain research ethics practices that were questionable. We conclude
      that a curriculum in research ethics should be developed for university faculty
      and that further qualitative studies should explore the basis of several of the
      attitudes regarding practices in research ethics.
FAU - Kandeel, Nahed
AU  - Kandeel N
AD  - Mansoura University (Egypt).
FAU - El-Nemer, Amina
AU  - El-Nemer A
FAU - Ali, Nahed M
AU  - Ali NM
FAU - Kassem, Heba
AU  - Kassem H
FAU - El-Setouhy, Maged
AU  - El-Setouhy M
FAU - Elgharieb, Mervat Elshabrawy
AU  - Elgharieb ME
FAU - Darwish, Magda
AU  - Darwish M
FAU - Awadalla, Nabil Joseph
AU  - Awadalla NJ
FAU - Moni, Malini
AU  - Moni M
FAU - Silverman, Henry J
AU  - Silverman HJ
LA  - eng
GR  - R25TW007090-01/TW/FIC NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - *Attitude
MH  - Biomedical Research/education/*ethics
MH  - Confidentiality/ethics
MH  - Cross-Sectional Studies
MH  - Curriculum
MH  - Education, Medical/*ethics
MH  - Egypt
MH  - *Ethics Committees, Research
MH  - *Faculty
MH  - Female
MH  - Health Services Needs and Demand
MH  - Humans
MH  - Informed Consent/ethics
MH  - Male
MH  - *Professional Competence
MH  - Universities
EDAT- 2012/01/10 06:00
MHDA- 2012/06/08 06:00
CRDT- 2012/01/10 06:00
PHST- 2012/01/10 06:00 [entrez]
PHST- 2012/01/10 06:00 [pubmed]
PHST- 2012/06/08 06:00 [medline]
AID - 10.1525/jer.2011.6.4.99 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2011 Dec;6(4):99-108. doi: 10.1525/jer.2011.6.4.99.


PMID- 22228063
OWN - NLM
STAT- MEDLINE
DCOM- 20120607
LR  - 20191210
IS  - 1556-2654 (Electronic)
IS  - 1556-2646 (Linking)
VI  - 6
IP  - 4
DP  - 2011 Dec
TI  - What women who use drugs have to say about ethical research: findings of an
      exploratory qualitative study.
PG  - 84-98
LID - 10.1525/jer.2011.6.4.84 [doi]
AB  - Drug users are generally seen as a vulnerable population requiring special
      protection in research; however, to date there has been little empirical research
      into the ethics of research with illicit drug users. Moreover, the available
      research has tended to treat "drug users" as a homogeneous category, and has
      failed to consider potential gender differences in users' experiences. Drawing on
      focus groups with twenty-seven female drug users in Vancouver, Canada, this study
      examines women's experiences of research and what they see as ethical and
      respectful engagement. Many study participants talked about feeling dehumanized
      as a result of prior research participation. Women were critical of the
      assumption that drug users lack the capacity to take part in research, and
      affirmed the appropriateness of financial incentives. A variety of motivations
      for research participation were identified, including a desire for financial gain
      and altruistic concerns such as a desire to help others. These findings suggest
      that women drug users' views on ethical research differ from prevailing
      assumptions among institutional review boards about how research with such
      populations should proceed.
FAU - Bell, Kirsten
AU  - Bell K
AD  - University of British Columbia, East Hastings Street, Vancouver, BC, Canada.
      amy.salmon@vch.ca
FAU - Salmon, Amy
AU  - Salmon A
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
RN  - 0 (Illicit Drugs)
SB  - IM
MH  - Adult
MH  - Altruism
MH  - *Attitude
MH  - Canada
MH  - *Ethics, Research
MH  - Female
MH  - Focus Groups
MH  - Humans
MH  - *Illicit Drugs
MH  - Motivation
MH  - Qualitative Research
MH  - *Research Subjects
MH  - *Substance-Related Disorders
MH  - *Vulnerable Populations
EDAT- 2012/01/10 06:00
MHDA- 2012/06/08 06:00
CRDT- 2012/01/10 06:00
PHST- 2012/01/10 06:00 [entrez]
PHST- 2012/01/10 06:00 [pubmed]
PHST- 2012/06/08 06:00 [medline]
AID - 10.1525/jer.2011.6.4.84 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2011 Dec;6(4):84-98. doi: 10.1525/jer.2011.6.4.84.


PMID- 22228062
OWN - NLM
STAT- MEDLINE
DCOM- 20120607
LR  - 20120109
IS  - 1556-2654 (Electronic)
IS  - 1556-2646 (Linking)
VI  - 6
IP  - 4
DP  - 2011 Dec
TI  - Information that should be given to HIV cohort participants during ongoing
      research: the viewpoints of patient representatives and research professionals.
PG  - 76-83
LID - 10.1525/jer.2011.6.4.76 [doi]
AB  - While investigators have a duty to provide research participants with summary
      findings at the end of a study, providing general information during the course
      of research is rarely considered. However, this raises an important ethical issue
      in the context of long-term studies such as cohorts or biobanks. We investigated 
      this issue in the context of two ANRS cohorts of HIV-infected patients, AQUITAINE
      and COPILOTE. Face-to-face interviews were conducted with HIV patient
      representatives and research professionals concerning the delivery of information
      in the course of the research. Respondents stated that participants wish to be
      informed of research results (both aggregate and individual) but also expect
      general information about the cohort itself, research progression, and what their
      participation may provide. It was concluded that information provided during the 
      course of the research may help participants to distinguish between care and
      research. The essential role of clinicians-investigators in providing information
      was emphasized.
FAU - Franrenet, Sandra
AU  - Franrenet S
AD  - Laboratoire d'Ethique Medicale et de Medecine Legale, Faculte de medecine,
      Universite Paris Descartes, 45 rue des Saints-Peres, Paris, France.
FAU - Moutel, Gregoire
AU  - Moutel G
FAU - Raffi, Francois
AU  - Raffi F
FAU - Dabis, Francois
AU  - Dabis F
FAU - Bruyand, Mathias
AU  - Bruyand M
FAU - Herve, Christian
AU  - Herve C
FAU - Leport, Catherine
AU  - Leport C
FAU - Duchange, Nathalie
AU  - Duchange N
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - *Attitude
MH  - Biomedical Research/*ethics
MH  - Cohort Studies
MH  - Disclosure/*ethics
MH  - *HIV Infections
MH  - Humans
MH  - *Informed Consent
MH  - Interviews as Topic
MH  - *Patient Advocacy
MH  - *Professional Role
MH  - *Research Personnel
MH  - Research Subjects
EDAT- 2012/01/10 06:00
MHDA- 2012/06/08 06:00
CRDT- 2012/01/10 06:00
PHST- 2012/01/10 06:00 [entrez]
PHST- 2012/01/10 06:00 [pubmed]
PHST- 2012/06/08 06:00 [medline]
AID - 10.1525/jer.2011.6.4.76 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2011 Dec;6(4):76-83. doi: 10.1525/jer.2011.6.4.76.


PMID- 22228061
OWN - NLM
STAT- MEDLINE
DCOM- 20120607
LR  - 20220330
IS  - 1556-2654 (Electronic)
IS  - 1556-2646 (Linking)
VI  - 6
IP  - 4
DP  - 2011 Dec
TI  - "My parents decide if I can. I decide if I want to." Children's views on
      participation in medical research.
PG  - 68-75
LID - 10.1525/jer.2011.6.4.68 [doi]
AB  - The participation of children in medical research raises many ethical issues, in 
      particular regarding assent. However, little is known about children's own views 
      on participation. This study presents results from interviews with children 10-12
      years old with and without experience in a large-scale longitudinal screening
      study. We identified five themes: (1) knowledge about research, (2) a sense of
      altruism, (3) shared decision-making and right to dissent, (4) notions of
      integrity, privacy, and access, and (5) understanding of disease risk and
      personal responsibilities. We conclude that the children feel positive towards
      medical research, and want to take an active part in decisions and have their
      integrity respected. However, the study also indicates that children who had
      participated in longitudinal screening had a limited understanding, suggesting
      the vital importance of providing information appropriate to their age and
      maturity. This information should be provided out of respect for the children as 
      persons, but also to promote their willingness to continue participating in
      longitudinal studies.
FAU - Swartling, Ulrica
AU  - Swartling U
AD  - Department of Clinical and Experimental Medicine, Faculty of Health Sciences,
      Linkoping University, Sweden. Ulrica.swartling@liu.se
FAU - Hansson, Mats G
AU  - Hansson MG
FAU - Ludvigsson, Johnny
AU  - Ludvigsson J
FAU - Nordgren, Anders
AU  - Nordgren A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Altruism
MH  - Biomedical Research/*ethics
MH  - Child
MH  - Comprehension
MH  - *Decision Making
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Human Rights
MH  - Humans
MH  - *Informed Consent By Minors
MH  - Interviews as Topic
MH  - Longitudinal Studies
MH  - Male
MH  - *Patient Selection
MH  - Personal Autonomy
MH  - *Research Subjects
MH  - Risk
MH  - Social Responsibility
EDAT- 2012/01/10 06:00
MHDA- 2012/06/08 06:00
CRDT- 2012/01/10 06:00
PHST- 2012/01/10 06:00 [entrez]
PHST- 2012/01/10 06:00 [pubmed]
PHST- 2012/06/08 06:00 [medline]
AID - 10.1525/jer.2011.6.4.68 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2011 Dec;6(4):68-75. doi: 10.1525/jer.2011.6.4.68.


PMID- 22228056
OWN - NLM
STAT- MEDLINE
DCOM- 20120607
LR  - 20211021
IS  - 1556-2654 (Electronic)
IS  - 1556-2646 (Linking)
VI  - 6
IP  - 4
DP  - 2011 Dec
TI  - Research participants' perspectives on genotype-driven research recruitment.
PG  - 3-20
LID - 10.1525/jer.2011.6.4.3 [doi]
AB  - Genotype-driven recruitment is a potentially powerful approach for studying human
      genetic variation but presents ethical challenges. We conducted in-depth
      interviews with research participants in six studies where such recruitment
      occurred. Nearly all responded favorably to the acceptability of recontact for
      research recruitment, and genotype-driven recruitment was viewed as a positive
      sign of scientific advancement. Reactions to questions about the disclosure of
      individual genetic research results varied. Common themes included explaining the
      purpose of recontact, informing decisions about further participation,
      reciprocity, "information is valuable," and the possibility of benefit, as well
      as concerns about undue distress and misunderstanding. Our findings suggest
      contact about additional research may be least concerning if it involves a known 
      element (e.g., trusted researchers). Also, for genotype-driven recruitment, it
      may be appropriate to set a lower bar for disclosure of individual results than
      the clinical utility threshold recommended more generally.
FAU - Beskow, Laura M
AU  - Beskow LM
AD  - Duke Institute for Genome Sciences & Policy, Duke University, Durham, NC 27708,
      USA. laura.beskow@duke.edu
FAU - Namey, Emily E
AU  - Namey EE
FAU - Cadigan, R Jean
AU  - Cadigan RJ
FAU - Brazg, Tracy
AU  - Brazg T
FAU - Crouch, Julia
AU  - Crouch J
FAU - Henderson, Gail E
AU  - Henderson GE
FAU - Michie, Marsha
AU  - Michie M
FAU - Nelson, Daniel K
AU  - Nelson DK
FAU - Tabor, Holly K
AU  - Tabor HK
FAU - Wilfond, Benjamin S
AU  - Wilfond BS
LA  - eng
GR  - P50HG004488/HG/NHGRI NIH HHS/United States
GR  - P50HG3374/HG/NHGRI NIH HHS/United States
GR  - P50 HG004488/HG/NHGRI NIH HHS/United States
GR  - RC1 HG005787/HG/NHGRI NIH HHS/United States
GR  - UL1 RR025014/RR/NCRR NIH HHS/United States
GR  - RC1HG005787/HG/NHGRI NIH HHS/United States
GR  - P50 HG003374/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Attitude
MH  - Disclosure/*ethics
MH  - Duty to Recontact/*ethics
MH  - Female
MH  - Genetic Research/*ethics
MH  - *Genotype
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Middle Aged
MH  - Patient Selection/*ethics
MH  - *Research Subjects
MH  - Young Adult
PMC - PMC3395316
MID - NIHMS387009
EDAT- 2012/01/10 06:00
MHDA- 2012/06/08 06:00
CRDT- 2012/01/10 06:00
PHST- 2012/01/10 06:00 [entrez]
PHST- 2012/01/10 06:00 [pubmed]
PHST- 2012/06/08 06:00 [medline]
AID - 10.1525/jer.2011.6.4.3 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2011 Dec;6(4):3-20. doi: 10.1525/jer.2011.6.4.3.


PMID- 22227282
OWN - NLM
STAT- MEDLINE
DCOM- 20120817
LR  - 20120402
IS  - 1096-0260 (Electronic)
IS  - 0091-7435 (Linking)
VI  - 54
IP  - 3-4
DP  - 2012 Mar-Apr
TI  - Radiation risks: critical analysis and commentary.
PG  - 280-2
LID - 10.1016/j.ypmed.2011.12.017 [doi]
AB  - OBJECTIVES: 1) To review and summarize what is known about the health risks of
      radiation. 2) To compare risks from medical imaging to background radiation and
      to exposure from nuclear accidents. METHODS: Literature review and summative
      critical analysis. RESULTS: Over the past several years, physicians and patients 
      have become increasingly aware of the potential risks of radiation exposure from 
      medical imaging. The Fukushima disaster further heightened public awareness of
      hazards associated with radiation and radioactivity. In the case of medical
      imaging, small but real risks of cancer and other radiation-induced disease must 
      be balanced against potential benefits of improved diagnostic accuracy. The
      ethical principle of autonomy tells us that patients should be informed of
      potential benefits and harms of radiation imaging, and should participate in
      shared decision making. In the case of nuclear power, benefits and especially
      harms are exceptionally difficult to estimate accurately. Nevertheless, we know
      that hazards from today's nuclear power plants will persist for many years,
      affecting future generations not benefiting from electrical power generated
      today. CONCLUSIONS: A deeper and more widespread understanding of potential
      benefits and harms of personal and societal choices relating to radiation
      exposure may lead to improved medical and societal decision-making.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Barrett, Bruce
AU  - Barrett B
AD  - Department of Family Medicine at University of Wisconsin School of Medicine and
      Public Health, Madison, WI 53715, USA. bruce.barrett@fammed.wisc.edu
FAU - Stiles, Melissa
AU  - Stiles M
FAU - Patterson, Jeff
AU  - Patterson J
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111229
PL  - United States
TA  - Prev Med
JT  - Preventive medicine
JID - 0322116
SB  - IM
MH  - Background Radiation/adverse effects
MH  - Dose-Response Relationship, Radiation
MH  - Environmental Exposure/adverse effects
MH  - Humans
MH  - Nuclear Power Plants
MH  - Radiation Injuries/*etiology
MH  - Radiography/adverse effects
MH  - Risk Assessment
EDAT- 2012/01/10 06:00
MHDA- 2012/08/18 06:00
CRDT- 2012/01/10 06:00
PHST- 2011/09/06 00:00 [received]
PHST- 2011/11/11 00:00 [revised]
PHST- 2011/12/20 00:00 [accepted]
PHST- 2012/01/10 06:00 [entrez]
PHST- 2012/01/10 06:00 [pubmed]
PHST- 2012/08/18 06:00 [medline]
AID - S0091-7435(11)00519-6 [pii]
AID - 10.1016/j.ypmed.2011.12.017 [doi]
PST - ppublish
SO  - Prev Med. 2012 Mar-Apr;54(3-4):280-2. doi: 10.1016/j.ypmed.2011.12.017. Epub 2011
      Dec 29.


PMID- 22225434
OWN - NLM
STAT- MEDLINE
DCOM- 20120508
LR  - 20120109
IS  - 1466-187X (Electronic)
IS  - 0142-159X (Linking)
VI  - 33
IP  - 12
DP  - 2011
TI  - How we developed a bioethics theme in an undergraduate medical curriculum.
PG  - 974-7
LID - 10.3109/0142159X.2011.588890 [doi]
AB  - The 5-year undergraduate medical curriculum at Aga Khan University integrates
      basic sciences with clinical and community health sciences. Multimodal strategies
      of teaching and learning, with an emphasis on problem-based learning, are
      utilized to equip students with knowledge, skills, behaviours, attitudes and
      values necessary for a high-calibre medical graduate. Bioethics teaching was
      introduced in the medical curriculum in 1988 and has since undergone several
      changes. In 2009, a multidisciplinary voluntary group began review of
      undergraduate bioethics teaching and invested over 350 man-hours in curricular
      revision. This involved formulating terminal objectives, delineating specific
      objectives and identifying instructional methodologies and assessment strategies 
      appropriate for the contents of each objective. Innovative strategies were
      specially devised to work within the time constraints of the existing medical
      curriculum and importantly, to increase student interest and engagement. The new 
      bioethics curriculum is designed to be comprehensive and robust, and strives to
      develop graduates who, in addition to being technically skilled and competent,
      are well-versed in the history and philosophy of ethics and bioethics and are
      ethical in their thinking and practice, especially in the context of a developing
      country like Pakistan where health indicators are among the worst in the region, 
      and clinical practices are not effectively regulated to ensure quality of care.
FAU - Ghias, Kulsoom
AU  - Ghias K
AD  - Department of Biological and Biomedical Sciences, Aga Khan University, Pakistan. 
      kulsoom.ghias@aku.edu
FAU - Ali, Syeda Kauser
AU  - Ali SK
FAU - Khan, Kausar S
AU  - Khan KS
FAU - Khan, Robyna
AU  - Khan R
FAU - Khan, Murad M
AU  - Khan MM
FAU - Farooqui, Arshi
AU  - Farooqui A
FAU - Nayani, Parvez
AU  - Nayani P
LA  - eng
PT  - Journal Article
PL  - England
TA  - Med Teach
JT  - Medical teacher
JID - 7909593
SB  - IM
MH  - Bioethics/*education
MH  - *Curriculum
MH  - Diffusion of Innovation
MH  - Education, Medical, Undergraduate/*ethics
MH  - Faculty, Medical/*organization & administration
MH  - Humans
MH  - Learning
MH  - Pakistan
MH  - Program Development/*methods
MH  - Program Evaluation
MH  - Teaching/*methods
EDAT- 2012/01/10 06:00
MHDA- 2012/05/09 06:00
CRDT- 2012/01/10 06:00
PHST- 2012/01/10 06:00 [entrez]
PHST- 2012/01/10 06:00 [pubmed]
PHST- 2012/05/09 06:00 [medline]
AID - 10.3109/0142159X.2011.588890 [doi]
PST - ppublish
SO  - Med Teach. 2011;33(12):974-7. doi: 10.3109/0142159X.2011.588890.


PMID- 22224140
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120824
LR  - 20211021
IS  - 1936-9018 (Electronic)
IS  - 1936-900X (Linking)
VI  - 12
IP  - 4
DP  - 2011 Nov
TI  - Implications and approach to incidental findings in live ultrasound models.
PG  - 472-4
LID - 10.5811/westjem.2011.2.2054 [doi]
AB  - INTRODUCTION: Incidental findings during ultrasound examinations occur frequently
      with live models in training sessions. Because of the broad scope of training
      sessions available, the ethics and guidelines of dealing with incidental findings
      in live models need to be discussed. METHODS: We provide a case of an endovaginal
      ultrasound that had significant unexpected findings. RESULTS: This report
      demonstrates an important finding uncovered during an endovaginal modeling
      session. CONCLUSION: Models should be notified beforehand of the possibility of
      an incidental finding, informed about it, made aware of potential associated
      costs, referred to another physician for follow-up, and provided a copy of the
      scans. A secure copy of the ultrasound scan should be stored for future
      reference.
FAU - Fox, J Christian
AU  - Fox JC
AD  - University of California, Irvine, Department of Emergency Medicine, Orange,
      California.
FAU - Richardson, Andrew G
AU  - Richardson AG
FAU - Lopez, Sarah
AU  - Lopez S
FAU - Solley, Matthew
AU  - Solley M
FAU - Lotfipour, Shahram
AU  - Lotfipour S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - West J Emerg Med
JT  - The western journal of emergency medicine
JID - 101476450
PMC - PMC3236140
EDAT- 2012/01/10 06:00
MHDA- 2012/01/10 06:01
CRDT- 2012/01/07 06:00
PHST- 2010/08/03 00:00 [received]
PHST- 2010/10/21 00:00 [revised]
PHST- 2011/02/07 00:00 [accepted]
PHST- 2012/01/07 06:00 [entrez]
PHST- 2012/01/10 06:00 [pubmed]
PHST- 2012/01/10 06:01 [medline]
AID - 10.5811/westjem.2011.2.2054 [doi]
PST - ppublish
SO  - West J Emerg Med. 2011 Nov;12(4):472-4. doi: 10.5811/westjem.2011.2.2054.


PMID- 22224101
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2228-5504 (Electronic)
IS  - 1735-9066 (Linking)
VI  - 16
IP  - 2
DP  - 2011 Spring
TI  - The effects of nursing discharge plan (post-discharge education and follow-up) on
      self-care ability in patients with chronic schizophrenia hospitalized in Razi
      psychiatric Center.
PG  - 162-8
AB  - BACKGROUND: Schizophrenia is a debilitating psychotic disorder that affects
      patients' personality, career-related and social functioning. Patients stop
      medications after discharge or inpatient care, when they feel relatively
      recovered. Most patients do not know that they are sick and they need medication 
      for recovery due to lack of information and cognitive impairment, which makes
      them incompetent for self-care. A well designed discharge plan with disease
      management, prevention cares and education along with follow-up can significantly
      improve patients and decrease the health care costs; because it helps them take
      care of themselves and maintain a certain level of health. This study aimed to
      determine the effect of discharge, education and follow-up program on self-care
      abilities of patients with chronic schizophrenia. METHODS: This was a
      quasi-experimental study, using a hospital based accessible sampling method.
      Participants included 60 schizophrenic patients who were randomly divided into
      two groups of intervention and control (30 patients in each group). After their
      symptoms were relatively controlled, the intervention group received a service of
      post-discharge program and home-care for 6 months. Data were collected before,
      and one month after education up to 6 month after discharge, using a demographic 
      data questionnaire and a researcher-made questionnaire for self-care. Validity
      and reliability of instruments were approved by content validity and test-retest,
      respectively. Also, ethical approval for this study was obtained from the
      University of Social Welfare and Rehabilitation Science. RESULTS: There was a
      significant difference between the self-care abilities after intervention (from
      month 1 to month 6) in the intervention group compared with the controls. It
      means that conducting a discharge plan, education and follow-up increased the
      self-care abilities of the participants in the intervention group compared with
      themselves and control group members. CONCLUSIONS: Educating patients and their
      families and follow-up cares after discharge along with medications led to
      independency, self-care improvement and cognitive and social functioning of
      schizophrenic patients.
FAU - Khankeh, Hamidreza
AU  - Khankeh H
AD  - Assistant Professor and Head of Educational Development Center, University of
      Social Welfare and Rehabilitation Sciences, Tehran, Iran.
FAU - Rahgozar, Mehdi
AU  - Rahgozar M
FAU - Ranjbar, Maryam
AU  - Ranjbar M
LA  - eng
PT  - Journal Article
PL  - India
TA  - Iran J Nurs Midwifery Res
JT  - Iranian journal of nursing and midwifery research
JID - 101558775
PMC - PMC3249767
OTO - NOTNLM
OT  - Discharge planning
OT  - schizophrenia
OT  - self-care
EDAT- 2012/01/10 06:00
MHDA- 2012/01/10 06:01
CRDT- 2012/01/07 06:00
PHST- 2010/11/02 00:00 [received]
PHST- 2011/01/05 00:00 [accepted]
PHST- 2012/01/07 06:00 [entrez]
PHST- 2012/01/10 06:00 [pubmed]
PHST- 2012/01/10 06:01 [medline]
PST - ppublish
SO  - Iran J Nurs Midwifery Res. 2011 Spring;16(2):162-8.


PMID- 22220490
OWN - NLM
STAT- MEDLINE
DCOM- 20120125
LR  - 20120106
IS  - 0033-2674 (Print)
IS  - 0033-2674 (Linking)
VI  - 45
IP  - 5
DP  - 2011 Sep-Oct
TI  - [Psychotherapy as cultural discourse].
PG  - 737-48
AB  - It is impossible to think about psychotherapy without reference to the cultural
      context. In order to understand the development of this domain it is helpful to
      apply the concept of cultural discourse. When we think about the over one hundred
      years' history of psychotherapy it becomes clear that understanding of a person, 
      his/her difficulties, psychopathology, the role of a psychotherapist,
      psychotherapy and its limitations have been changing. It depended on the
      acknowledged epistemological horizon. Therefore it is important to observe the
      process of creating discourses related to psychotherapeutic "reality". These
      discourses are not simply descriptive but they participate in creation of
      reality. They are not neutral, on the contrary, their application has broad
      practical, theoretical, ethical and legal consequences. An attempt to describe
      the culture, or better cultures, we are immersed in, is an attempt to describe
      the identity of contemporary psychotherapists. This article, referring to the
      constructionists' perspective and works of Michael Foucault, presents how
      cultural changes influence psychotherapists' ways of thinking, their practice and
      presence in social space.
FAU - Jozefik, Barbara
AU  - Jozefik B
AD  - Klinika Psychiatrii Dzieci i Mlodziezy UJ CM.
LA  - pol
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Psychoterapia jako dyskurs kulturowy.
PL  - Poland
TA  - Psychiatr Pol
JT  - Psychiatria polska
JID - 0103314
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Attitude to Health
MH  - *Cultural Characteristics
MH  - Humans
MH  - Mental Disorders/*therapy
MH  - *Physician-Patient Relations
MH  - *Professional Role
MH  - Psychotherapy/*methods
MH  - Social Perception
MH  - Social Values
EDAT- 2012/01/10 06:00
MHDA- 2012/01/26 06:00
CRDT- 2012/01/07 06:00
PHST- 2012/01/07 06:00 [entrez]
PHST- 2012/01/10 06:00 [pubmed]
PHST- 2012/01/26 06:00 [medline]
PST - ppublish
SO  - Psychiatr Pol. 2011 Sep-Oct;45(5):737-48.


PMID- 22220463
OWN - NLM
STAT- MEDLINE
DCOM- 20120131
LR  - 20220310
IS  - 0350-6134 (Print)
IS  - 0350-6134 (Linking)
VI  - 35 Suppl 2
DP  - 2011 Sep
TI  - Placebo in the treatment of pain.
PG  - 319-23
AB  - Placebo is the use of the substance or procedure without specific activity for
      the condition that is trying to be healed. In medicine, benefits of placebo
      effect are used since 1985 and 1978 placebo effect was first scientifically
      confirmed. It was found that placebo induced analgesia depends on the release of 
      endogenous opiates in the brain and that the placebo effect can be undone using
      the opiates antagonist naloxone. Functional magnetic resonance imaging of the
      brain showed that placebo analgesia was obtained regarding the activation and
      increased functional relationship between ant. cingulate, prefrontal,
      orbitofrontal, and insular cortex, nucleus accumlens, amygdala, periaqueduktalne 
      gray matter and spinal cord. Placebo also facilitates descending inhibition of
      nociceptive reflexes through periacvaeductal gray substance. Placebo effect can
      be achieved in several ways: by using pharmacological preparations or simulation 
      of operating or other procedures. This phenomenon is associated with perception
      and expectation of the patient. To achieve the effect of placebo it is essential 
      degree of the suggestions of the person who prescribe a placebo, and the degree
      of belief of the person receiving the placebo. Expected effect of placebo is to
      achieve the same effect as the right remedy. Achieved placebo effect depends on
      the way of presentation. If a substance is presented as harmful, it may cause
      harmful effects, called 'nocebo" effect. Placebo effect is not equal in all
      patients, same as the real effect of the drug is not always equal in all
      patients. Application of placebo in terms of analgesia will cause a positive
      response in 35% of patients. Almost the same percentage (36%) of patients will
      respond to treatment with morphine in medium doses (6-8 mg). Therefore, one
      should remember that response to placebo does not mean that a person simulates
      the pain and then it is unethical to withhold the correct treatment especially in
      light of findings that the prefrontal cortex is activated expecting liberation of
      pain and how this action reduce activities in brain regions responsible for
      sensation of pain (thalamus, somatosensory cortex and other parts of the cortex).
      However, the use of placebos is ethically, legally and morally very dubious. The 
      basis for the placebo effect is deception. It undermines honest relationship and 
      trust between doctor and patient which is extremely important for successful
      treatment. Consciously giving placebos to patients for a condition that can be
      adequately treated, with prejudice the right of patients to the best care
      possible, opens up many bioethical issues. Despite all the current knowledge
      level, placebo effect remains still a scientific mystery.
FAU - Dobrila-Dintinjana, Renata
AU  - Dobrila-Dintinjana R
AD  - Clinic for Radiotherapy and Oncology, Rijeka University Hospital, Rijeka,
      Croatia. renatadobrila@windowslive.com
FAU - Nacinovic-Duletic, Antica
AU  - Nacinovic-Duletic A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Croatia
TA  - Coll Antropol
JT  - Collegium antropologicum
JID - 8003354
SB  - IM
MH  - Analgesia/*methods
MH  - Humans
MH  - Pain Management/*methods
MH  - Pain Threshold/*physiology
MH  - *Placebo Effect
EDAT- 2012/01/10 06:00
MHDA- 2012/02/01 06:00
CRDT- 2012/01/07 06:00
PHST- 2012/01/07 06:00 [entrez]
PHST- 2012/01/10 06:00 [pubmed]
PHST- 2012/02/01 06:00 [medline]
PST - ppublish
SO  - Coll Antropol. 2011 Sep;35 Suppl 2:319-23.


PMID- 22219407
OWN - NLM
STAT- MEDLINE
DCOM- 20120524
LR  - 20191210
IS  - 1873-734X (Electronic)
IS  - 1010-7940 (Linking)
VI  - 41
IP  - 3
DP  - 2012 Mar
TI  - Curved cutter stapler for the application of bronchial sutures in anatomic
      pulmonary resections: the clinical experience of 139 cases.
PG  - 653-6
LID - 10.1093/ejcts/ezr090 [doi]
AB  - OBJECTIVES: One of the fundamental steps in an anatomical pulmonary resection is 
      the main and lobar bronchus suture. Nowadays, two different types of staplers are
      on the market: the linear TA stapler for open surgery (Tyco Healthcare Group LP, 
      Norwalk, CT, USA), which is based on a 'guillotine' mechanism, sewing, but not
      cutting the bronchus, and the endoscopic linear stapler which both cuts and sews.
      This study aimed to fill the void in the use of an instrument used to staple and 
      cut at the same time in 'open' thoracic surgery, eliminating the need for a
      scalpel: the curved cutter stapler (Contour Curved Cutter Stapler; Ethicon
      Endo-Surgery, Inc., Cincinnati, OH, USA). METHODS: Between May 2009 and March
      2011, the Contour Curved Stapler (Ethicon) was used for the bronchus in 139 cases
      of non-small cell lung carcinoma (NSCLC)-29 females and 110 males ranging between
      48 and 85 years (average 71.1)-and comprising 115 lobectomies (8 bilobectomies)
      and 24 pneumonectomies (8 on the right lung, 16 on the left lung). RESULTS: All
      patients underwent a bronchoscopic check-up 30 days after they were discharged:
      in all cases, the bronchial stump was clearly within normal limits. No cases of
      bronchopleural fistulas were observed in the 139 patients. CONCLUSIONS: On the
      basis of this study, the curved cutter stapler showed to be a satisfactory device
      for securing the bronchus during an anatomic resection (whether lobar or main),
      in 'open' thoracic surgery. However, even though there were no cases of fistula, 
      we consider that our data is still too limited to be statistically significant.
FAU - Sardelli, Paolo
AU  - Sardelli P
AD  - Department of Thoracic Surgery, San Paolo Hospital, Bari, Italy.
      paolosardelli@gmail.com
FAU - Barrettara, Barbara
AU  - Barrettara B
FAU - Cisternino, Marco Luigi
AU  - Cisternino ML
FAU - Napoli, Gaetano
AU  - Napoli G
FAU - Lacitignola, Angelo
AU  - Lacitignola A
FAU - Quitadamo, Stefania
AU  - Quitadamo S
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20111221
PL  - Germany
TA  - Eur J Cardiothorac Surg
JT  - European journal of cardio-thoracic surgery : official journal of the European
      Association for Cardio-thoracic Surgery
JID - 8804069
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Bronchi/*surgery
MH  - Bronchial Fistula/etiology/prevention & control
MH  - Carcinoma, Non-Small-Cell Lung/*surgery
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/*surgery
MH  - Male
MH  - Middle Aged
MH  - Pleural Diseases/etiology/prevention & control
MH  - Pneumonectomy/adverse effects/*instrumentation/methods
MH  - Respiratory Tract Fistula/etiology/prevention & control
MH  - *Surgical Staplers
MH  - Surgical Stapling
EDAT- 2012/01/06 06:00
MHDA- 2012/05/25 06:00
CRDT- 2012/01/06 06:00
PHST- 2012/01/06 06:00 [entrez]
PHST- 2012/01/06 06:00 [pubmed]
PHST- 2012/05/25 06:00 [medline]
AID - ezr090 [pii]
AID - 10.1093/ejcts/ezr090 [doi]
PST - ppublish
SO  - Eur J Cardiothorac Surg. 2012 Mar;41(3):653-6. doi: 10.1093/ejcts/ezr090. Epub
      2011 Dec 21.


PMID- 22219405
OWN - NLM
STAT- MEDLINE
DCOM- 20120524
LR  - 20220330
IS  - 1873-734X (Electronic)
IS  - 1010-7940 (Linking)
VI  - 41
IP  - 3
DP  - 2012 Mar
TI  - Adverse effects of fibrin sealants in thoracic surgery: the safety of a new
      fibrin sealant: multicentre, randomized, controlled, clinical trial.
PG  - 657-62
LID - 10.1093/ejcts/ezr083 [doi]
AB  - OBJECTIVES: The safety of fibrin sealants (FS) has been questioned in the light
      of recent reports of adverse effects. We evaluated the safety of a new FS in a
      randomized controlled trial (RCT). METHODS: Multicentre, open-label Phase II/III 
      RCT to evaluate the safety of the new FS. The trial was approved by the Ethic
      Committee of each three participating Centre. FS includes two components
      (component 1: fibrinogen; component 2: thrombin), each of them subjected to two
      viral inactivation procedures. Out of 200 screened patients, 185 eligible
      patients (49 females, 136 males), aged between 18 and 75 years, undergoing major 
      thoracic surgery were randomized to receive FS (#91 patients) as an adjuvant for 
      air leak control or no treatment (#94 patients, control group). Safety variables 
      were: percentage of subjects with adverse events associated with the therapy;
      formation of antibodies against bovine aprotinin; vital signs (blood pressure,
      body temperature, heart and respiratory rate); laboratory parameters. RESULTS:
      Overall operative mortality was 3.2% (6/185), 1.1% in the FS group and 5.3% in
      the control group, respectively. Twenty patients (22%) had adverse events in the 
      FS group and 22 (23.4%) in the control group. Atrial fibrillation (five patients 
      in the FS group and four in the control group) and hyperpyrexia (five and seven
      patients, respectively, in the two groups) were the most common adverse events.
      No patient reported thromboembolic events (pulmonary embolism or deep vein
      thrombosis) during the in hospital stay or within 1 month from discharge. None of
      the adverse events was considered as treatment related. The formation of bovine
      aprotinin antibodies was reported in a total of 34 patients (37.4%) in the FS
      group and was not related to any adverse effect. CONCLUSIONS: The present RCT did
      not show any increased risk of adverse events, and of surgical complications,
      related to the use of the new FS.
FAU - Cardillo, Giuseppe
AU  - Cardillo G
AD  - Unit of Thoracic Surgery, Carlo Forlanini Hospital, Azienda Ospedaliera S.
      Camillo Forlanini, Rome, Italy. gcardillo@scamilloforlanini.rm.it
FAU - Carleo, Francesco
AU  - Carleo F
FAU - Carbone, Luigi
AU  - Carbone L
FAU - De Massimi, Alessia Raffaella
AU  - De Massimi AR
FAU - Lococo, Achille
AU  - Lococo A
FAU - Santini, Paolo F
AU  - Santini PF
FAU - Janni, Alberto
AU  - Janni A
FAU - Gonfiotti, Alessandro
AU  - Gonfiotti A
LA  - eng
PT  - Clinical Trial, Phase II
PT  - Clinical Trial, Phase III
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20111216
PL  - Germany
TA  - Eur J Cardiothorac Surg
JT  - European journal of cardio-thoracic surgery : official journal of the European
      Association for Cardio-thoracic Surgery
JID - 8804069
RN  - 0 (Fibrin Tissue Adhesive)
RN  - 0 (Hemostatics)
RN  - 0 (Tissue Adhesives)
RN  - 9087-70-1 (Aprotinin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Antibody Formation
MH  - Aprotinin/immunology
MH  - Atrial Fibrillation/chemically induced
MH  - Female
MH  - Fever/chemically induced
MH  - Fibrin Tissue Adhesive/*adverse effects/therapeutic use
MH  - Hemostasis, Surgical/adverse effects/methods
MH  - Hemostatics/*adverse effects/therapeutic use
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pleural Effusion/etiology/prevention & control
MH  - Pneumonectomy/adverse effects/*methods
MH  - Tissue Adhesives/*adverse effects/therapeutic use
MH  - Young Adult
EDAT- 2012/01/06 06:00
MHDA- 2012/05/25 06:00
CRDT- 2012/01/06 06:00
PHST- 2012/01/06 06:00 [entrez]
PHST- 2012/01/06 06:00 [pubmed]
PHST- 2012/05/25 06:00 [medline]
AID - ezr083 [pii]
AID - 10.1093/ejcts/ezr083 [doi]
PST - ppublish
SO  - Eur J Cardiothorac Surg. 2012 Mar;41(3):657-62. doi: 10.1093/ejcts/ezr083. Epub
      2011 Dec 16.


PMID- 22216581
OWN - NLM
STAT- MEDLINE
DCOM- 20120125
LR  - 20120105
IS  - 1461-3123 (Print)
IS  - 1461-3123 (Linking)
VI  - 14
IP  - 11
DP  - 2011 Dec
TI  - A fight for the right to life.
PG  - 15-6
AB  - This paper describes the experience of 'Pamela*, mother of a child with spina
      bifida, diagnosed prenatally. It was disclosed during a research project
      exploring 'Family Centred Care' (FCC) with disabled children, and a very
      challenging ethical dilemma arose. This mother felt unsupported in her decision
      to go ahead with having her baby with spina bifida; this was in contrast to the
      support she received for her disabled child, once born. The discussion will focus
      around the challenge of supporting parents in decision making in midwifery and
      health care practice.
FAU - Pickering, Dawn
AU  - Pickering D
AD  - Cardiff University, School of Healthcare Studies.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Pract Midwife
JT  - The practising midwife
JID - 9814758
MH  - Adult
MH  - Attitude to Health
MH  - Decision Making/*ethics
MH  - Female
MH  - *Human Rights
MH  - Humans
MH  - Pregnancy
MH  - Pregnant Women/*psychology
MH  - Prenatal Care/ethics
MH  - Prenatal Diagnosis/*ethics
MH  - Professional-Patient Relations
MH  - Spinal Dysraphism/nursing/*psychology
MH  - *Value of Life
EDAT- 2012/01/06 06:00
MHDA- 2012/01/26 06:00
CRDT- 2012/01/06 06:00
PHST- 2012/01/06 06:00 [entrez]
PHST- 2012/01/06 06:00 [pubmed]
PHST- 2012/01/26 06:00 [medline]
PST - ppublish
SO  - Pract Midwife. 2011 Dec;14(11):15-6.


PMID- 22216475
OWN - HMD
STAT- MEDLINE
DCOM- 20121002
LR  - 20220311
IS  - 1360-7456 (Print)
IS  - 1360-7456 (Linking)
VI  - 52
IP  - 3
DP  - 2011
TI  - A new inequality? Privatisation, urban bias, migration and medical tourism.
PG  - 260-71
AB  - Access to health care in developing countries, the main destinations of medical
      tourists, is notoriously uneven, and often becoming more so. Medical tourism,
      urban bias and privatisation have combined to exacerbate this trend. This is
      exemplified in both Thailand and India, where regional areas have been
      disadvantaged by the migration of health-care workers to hospitals focusing on
      medical tourism, neo-liberal national financial provision for medical tourism
      (and related tourism campaigns) and evidence of trickle-down gains is lacking.
      Medical tourism challenges rather than complements local health care providers,
      distorts national health care systems, and raises critical national economic,
      ethical and social questions.
FAU - Connell, John
AU  - Connell J
AD  - University of Sydney, Australia.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - England
TA  - Asia Pac Viewp
JT  - Asia Pacific viewpoint
JID - 101091309
MH  - Asia/ethnology
MH  - Cross-Cultural Comparison
MH  - Delivery of Health Care/economics/ethnology/history/legislation & jurisprudence
MH  - Developing Countries/economics/history
MH  - *Emigrants and Immigrants/education/history/legislation &
      jurisprudence/psychology
MH  - *Ethics/history
MH  - *Health Services Accessibility/economics/history/legislation & jurisprudence
MH  - History, 20th Century
MH  - History, 21st Century
MH  - India/ethnology
MH  - *Medical Tourism/economics/history/legislation & jurisprudence/psychology
MH  - *Privatization/economics/history/legislation & jurisprudence
MH  - *Social Justice/economics/education/history/legislation &
      jurisprudence/psychology
MH  - Socioeconomic Factors/history
MH  - Thailand/ethnology
EDAT- 2012/01/06 06:00
MHDA- 2012/10/04 06:00
CRDT- 2012/01/06 06:00
PHST- 2012/01/06 06:00 [entrez]
PHST- 2012/01/06 06:00 [pubmed]
PHST- 2012/10/04 06:00 [medline]
AID - 10.1111/j.1467-8373.2011.01454.x [doi]
PST - ppublish
SO  - Asia Pac Viewp. 2011;52(3):260-71. doi: 10.1111/j.1467-8373.2011.01454.x.


PMID- 22216290
OWN - NLM
STAT- MEDLINE
DCOM- 20120521
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 6
IP  - 12
DP  - 2011
TI  - Attitudes toward and uptake of H1N1 vaccine among health care workers during the 
      2009 H1N1 pandemic.
PG  - e29478
LID - 10.1371/journal.pone.0029478 [doi]
AB  - BACKGROUND: Though recommended by many and mandated by some, influenza
      vaccination rates among health care workers, even in pandemics, remain below
      optimal levels. The objective of this study was to assess vaccination uptake,
      attitudes, and distinguishing characteristics (including doctor-nurse
      differences) of health care workers who did and did not receive the pandemic H1N1
      influenza vaccine in late 2009. METHODOLOGY/PRINCIPAL FINDINGS: In early 2010 we 
      mailed a self-administered survey to 800 physicians and 800 nurses currently
      licensed and practicing in Minnesota. 1,073 individuals responded (cooperation
      rate: 69%). 85% and 62% of Minnesota physicians and nurses, respectively,
      reported being vaccinated. Accurately estimating the risk of vaccine side effects
      (OR 2.0; 95% CI 1.5-2.7), agreeing with a professional obligation to be
      vaccinated (OR 10.1; 95% CI 7.1-14.2), an ethical obligation to follow public
      health authorities' recommendations (OR 9.9; 95% CI 6.6-14.9), and laws mandating
      pandemic vaccination (OR 3.1; 95% CI 2.3-4.1) were all independently associated
      with receiving the H1N1 influenza vaccine. CONCLUSIONS/SIGNIFICANCE: While a
      majority of health care workers in one midwestern state reported receiving the
      pandemic H1N1 vaccine, physicians and nurses differed significantly in
      vaccination uptake. Several key attitudes and perceptions may influence health
      care workers' decisions regarding vaccination. These data inform how states might
      optimally enlist health care workers' support in achieving vaccination goals
      during a pandemic.
CI  - (c) 2011 Henriksen Hellyer et al.
FAU - Henriksen Hellyer, Joan M
AU  - Henriksen Hellyer JM
AD  - Program in Professionalism and Ethics, Mayo Clinic, Rochester, Minnesota, USA.
FAU - DeVries, Aaron S
AU  - DeVries AS
FAU - Jenkins, Sarah M
AU  - Jenkins SM
FAU - Lackore, Kandace A
AU  - Lackore KA
FAU - James, Katherine M
AU  - James KM
FAU - Ziegenfuss, Jeanette Y
AU  - Ziegenfuss JY
FAU - Poland, Gregory A
AU  - Poland GA
FAU - Tilburt, Jon C
AU  - Tilburt JC
LA  - eng
PT  - Journal Article
DEP - 20111222
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Influenza Vaccines)
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Humans
MH  - Influenza A Virus, H1N1 Subtype/*isolation & purification
MH  - Influenza Vaccines/*administration & dosage/adverse effects
MH  - Influenza, Human/*epidemiology/*prevention & control
MH  - Middle Aged
MH  - Minnesota
MH  - Nurses/psychology
MH  - Physicians/psychology
PMC - PMC3245279
EDAT- 2012/01/05 06:00
MHDA- 2012/05/23 06:00
CRDT- 2012/01/05 06:00
PHST- 2011/08/04 00:00 [received]
PHST- 2011/11/29 00:00 [accepted]
PHST- 2012/01/05 06:00 [entrez]
PHST- 2012/01/05 06:00 [pubmed]
PHST- 2012/05/23 06:00 [medline]
AID - 10.1371/journal.pone.0029478 [doi]
AID - PONE-D-11-15084 [pii]
PST - ppublish
SO  - PLoS One. 2011;6(12):e29478. doi: 10.1371/journal.pone.0029478. Epub 2011 Dec 22.


PMID- 22215406
OWN - NLM
STAT- MEDLINE
DCOM- 20120717
LR  - 20120104
IS  - 0717-6163 (Electronic)
IS  - 0034-9887 (Linking)
VI  - 139
IP  - 9
DP  - 2011 Sep
TI  - [Scientific ethics of the abortion with anencephalic fetus].
PG  - 1235-9
LID - /S0034-98872011000900019 [doi]
AB  - author proposes, from the perspective of the Scientific Ethics, to assimilate
      anencephalic fetuses to non-human fetuses because they have a large deficiency of
      the brain that is the organ for human specificity. This proposal comes after
      considering arguments and facts from ontogeny, phylogeny, from the situation of
      loss of the brain in the adult life and from the organic specificity of the human
      condition given by the brain. If anencephalic fetuses are not human, the
      interruption of their pregnancy cannot be considered as abortion, regardless the 
      pregnancy stage.
FAU - Valenzuela, Carlos Y
AU  - Valenzuela CY
AD  - Programa de Genetica Humana, Instituto de Ciencias Biomedicas, Facultad de
      Medicina, Universidad de Chile, Santiago, Chile. cvalenzu@med.uchile.cl
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Etica cientifica del aborto en caso de anencefalia.
DEP - 20111117
PL  - Chile
TA  - Rev Med Chil
JT  - Revista medica de Chile
JID - 0404312
SB  - IM
MH  - Abortion, Induced/*ethics
MH  - *Anencephaly
MH  - Bioethical Issues
MH  - Female
MH  - Humans
MH  - *Personhood
MH  - Pregnancy
EDAT- 2012/01/05 06:00
MHDA- 2012/07/18 06:00
CRDT- 2012/01/05 06:00
PHST- 2012/01/05 06:00 [entrez]
PHST- 2012/01/05 06:00 [pubmed]
PHST- 2012/07/18 06:00 [medline]
AID - S0034-98872011000900019 [pii]
AID - /S0034-98872011000900019 [doi]
PST - ppublish
SO  - Rev Med Chil. 2011 Sep;139(9):1235-9. doi: /S0034-98872011000900019. Epub 2011
      Nov 17.


PMID- 22215405
OWN - NLM
STAT- MEDLINE
DCOM- 20120717
LR  - 20120104
IS  - 0717-6163 (Electronic)
IS  - 0034-9887 (Linking)
VI  - 139
IP  - 9
DP  - 2011 Sep
TI  - [Should we hydrate terminally ill patients?].
PG  - 1229-34
LID - /S0034-98872011000900018 [doi]
AB  - Terminally ill patients frequently have difficulties with fluid and food intake. 
      The indication of artificial hydration in these patients has been subject of
      intense debate in the past years and the clinical practice widely varies, mostly 
      based on anecdotal data and not on clinical evidence about risks and benefits
      associated to artificial hydration in terminal patients. There are not only
      technical questions concerning benefits and risks associated to artificial
      hydration, but also questions related to the ethical principles and values
      involved. Several topics, such as the effect of artificial hydration alleviating 
      symptoms or reversing neurological alterations as delirium, its life prolonging
      effect or if it promotes unnecessary suffering, are discussed. In this review we 
      will analyze clinical benefits and risks associated to artificial hydration in
      terminal patients, making reference to some ethical principles involved.
FAU - Palma, Alejandra
AU  - Palma A
AD  - Centro de Bioetica, Pontificia Universidad Catolica de Chile, Santiago, Chile.
      mpalmab@uc.cl
FAU - Said, Juan Carlos
AU  - Said JC
FAU - Taboada, Paulina
AU  - Taboada P
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
TT  - inverted question markEs necesario hidratar artificialmente a los pacientes
      terminales?
DEP - 20111117
PL  - Chile
TA  - Rev Med Chil
JT  - Revista medica de Chile
JID - 0404312
SB  - IM
MH  - Fluid Therapy/adverse effects/*standards
MH  - Humans
MH  - Practice Guidelines as Topic
MH  - Risk Factors
MH  - Terminal Care/ethics/*standards
MH  - Terminally Ill
EDAT- 2012/01/05 06:00
MHDA- 2012/07/18 06:00
CRDT- 2012/01/05 06:00
PHST- 2012/01/05 06:00 [entrez]
PHST- 2012/01/05 06:00 [pubmed]
PHST- 2012/07/18 06:00 [medline]
AID - S0034-98872011000900018 [pii]
AID - /S0034-98872011000900018 [doi]
PST - ppublish
SO  - Rev Med Chil. 2011 Sep;139(9):1229-34. doi: /S0034-98872011000900018. Epub 2011
      Nov 17.


PMID- 22215343
OWN - NLM
STAT- MEDLINE
DCOM- 20120711
LR  - 20120104
IS  - 0717-6163 (Electronic)
IS  - 0034-9887 (Linking)
VI  - 139
IP  - 8
DP  - 2011 Aug
TI  - [Ethical aspects of academic management in a faculty of medicine].
PG  - 1097-102
LID - /S0034-98872011000800018 [doi]
AB  - This article states that the incorporation of ethical issues such as bioethics
      and principles of good practice, facilitates the academic management in a Faculty
      of Medicine. It presents some interesting aspects necessary to carry out a
      quality academic management that serves the university mission and its
      educational and research project. It underlines good practices regarding not only
      professional relations but also organizational aspects. It includes an analysis
      of academic management and its association with quality and leadership, it
      reflects on the ethical values of quality work and on the theory of functional or
      interactional leadership, a key element to boost the development of a university 
      health institution.
FAU - Sanchez D, Ignacio
AU  - Sanchez D I
AD  - Departamento de Pediatria, Facultad de Medicina, Pontificia Universidad Catolica 
      de Chile, Santiago, Chile. igsan@med.puc.cl
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Aspectos eticos de la gestion academica en una Facultad de Medicina.
DEP - 20111220
PL  - Chile
TA  - Rev Med Chil
JT  - Revista medica de Chile
JID - 0404312
SB  - IM
MH  - Administrative Personnel/*ethics
MH  - Bioethical Issues
MH  - Faculty, Medical/*organization & administration
MH  - Humans
MH  - *Leadership
EDAT- 2012/01/05 06:00
MHDA- 2012/07/12 06:00
CRDT- 2012/01/05 06:00
PHST- 2012/01/05 06:00 [entrez]
PHST- 2012/01/05 06:00 [pubmed]
PHST- 2012/07/12 06:00 [medline]
AID - S0034-98872011000800018 [pii]
AID - /S0034-98872011000800018 [doi]
PST - ppublish
SO  - Rev Med Chil. 2011 Aug;139(8):1097-102. doi: /S0034-98872011000800018. Epub 2011 
      Dec 20.


PMID- 22214043
OWN - NLM
STAT- MEDLINE
DCOM- 20120207
LR  - 20191112
IS  - 1755-6171 (Print)
IS  - 1755-6171 (Linking)
VI  - 48
IP  - 3
DP  - 2011 Aug
TI  - "We are not aliens, we're people, and we have rights." Canadian human rights
      discourse and high school climate for LGBTQ students.
PG  - 275-312
AB  - Canadian law protects people from discrimination on the grounds of sexual
      orientation, but our public schools do not fulfill their ethical and legal
      obligations where sexual and gender minority youth are concerned. This article
      reports on a national survey study on homophobia and transphobia in Canadian high
      schools. Participants (n = 3,607) were questioned about school climate,
      harassment, school attachment, and institutional interventions. We found that
      schools were neither safe nor respectful for sexual and gender minority students,
      and we argue that ongoing exposure to this situation undermines students' respect
      for the Charter of Rights and their faith in adults.
FAU - Taylor, Catherine
AU  - Taylor C
AD  - Department of Rhetoric, Writing & Communications and Faculty of Education,
      University of Winnipeg, 515 Portage Avenue, Winnipeg, Manitoba, Canada R3B 2E9.
      c.taylor@uwinnipeg.ca
FAU - Peter, Tracey
AU  - Peter T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Can Rev Sociol
JT  - Canadian review of sociology = Revue canadienne de sociologie
JID - 101320224
MH  - Adaptation, Psychological
MH  - Adolescent
MH  - *Bisexuality/psychology
MH  - Canada
MH  - Female
MH  - *Homosexuality/psychology
MH  - *Human Rights
MH  - Humans
MH  - Male
MH  - *Prejudice
MH  - Safety
MH  - Sexual Harassment
MH  - Social Behavior
MH  - Social Isolation
MH  - *Students/psychology
MH  - *Transsexualism/psychology
MH  - Violence/statistics & numerical data
MH  - Young Adult
EDAT- 2012/01/05 06:00
MHDA- 2012/02/09 06:00
CRDT- 2012/01/05 06:00
PHST- 2012/01/05 06:00 [entrez]
PHST- 2012/01/05 06:00 [pubmed]
PHST- 2012/02/09 06:00 [medline]
AID - 10.1111/j.1755-618x.2011.01266.x [doi]
PST - ppublish
SO  - Can Rev Sociol. 2011 Aug;48(3):275-312. doi: 10.1111/j.1755-618x.2011.01266.x.


PMID- 22213783
OWN - NLM
STAT- MEDLINE
DCOM- 20120605
LR  - 20220409
IS  - 1662-8063 (Electronic)
IS  - 1662-4246 (Linking)
VI  - 15
IP  - 2
DP  - 2012
TI  - Balancing the risks and benefits of genomic data sharing: genome research
      participants' perspectives.
PG  - 106-14
LID - 10.1159/000334718 [doi]
AB  - BACKGROUND: Technological advancements are rapidly propelling the field of genome
      research forward, while lawmakers attempt to keep apace with the risks these
      advances bear. Balancing normative concerns of maximizing data utility and
      protecting human subjects, whose privacy is at risk due to the identifiability of
      DNA data, are central to policy decisions. Research on genome research
      participants making real-time data sharing decisions is limited; yet, these
      perspectives could provide critical information to ongoing deliberations.
      METHODS: We conducted a randomized trial of 3 consent types affording varying
      levels of control over data release decisions. After debriefing participants
      about the randomization process, we invited them to a follow-up interview to
      assess their attitudes toward genetic research, privacy and data sharing.
      RESULTS: Participants were more restrictive in their reported data sharing
      preferences than in their actual data sharing decisions. They saw both benefits
      and risks associated with sharing their genomic data, but risks were seen as less
      concrete or happening in the future, and were largely outweighed by purported
      benefits. CONCLUSION: Policymakers must respect that participants' assessment of 
      the risks and benefits of data sharing and their privacy-utility determinations, 
      which are associated with their final data release decisions, vary. In order to
      advance the ethical conduct of genome research, proposed policy changes should
      carefully consider these stakeholder perspectives.
CI  - Copyright (c) 2011 S. Karger AG, Basel.
FAU - Oliver, J M
AU  - Oliver JM
AD  - Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston,
      Tex 77030, USA.
FAU - Slashinski, M J
AU  - Slashinski MJ
FAU - Wang, T
AU  - Wang T
FAU - Kelly, P A
AU  - Kelly PA
FAU - Hilsenbeck, S G
AU  - Hilsenbeck SG
FAU - McGuire, A L
AU  - McGuire AL
LA  - eng
GR  - P30 CA125123/CA/NCI NIH HHS/United States
GR  - R01 HG004333/HG/NHGRI NIH HHS/United States
GR  - P30CA125123/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20111230
PL  - Switzerland
TA  - Public Health Genomics
JT  - Public health genomics
JID - 101474167
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Confidentiality
MH  - Female
MH  - Follow-Up Studies
MH  - Genetic Privacy/*ethics
MH  - Genetic Research/*ethics
MH  - Genome, Human/*genetics
MH  - Genomics/*ethics
MH  - Humans
MH  - Information Dissemination/*ethics
MH  - Informed Consent
MH  - Male
MH  - Middle Aged
MH  - Risk Assessment
MH  - Young Adult
PMC - PMC3318928
EDAT- 2012/01/04 06:00
MHDA- 2012/06/06 06:00
CRDT- 2012/01/04 06:00
PHST- 2011/08/26 00:00 [received]
PHST- 2011/10/24 00:00 [accepted]
PHST- 2012/01/04 06:00 [entrez]
PHST- 2012/01/04 06:00 [pubmed]
PHST- 2012/06/06 06:00 [medline]
AID - 000334718 [pii]
AID - 10.1159/000334718 [doi]
PST - ppublish
SO  - Public Health Genomics. 2012;15(2):106-14. doi: 10.1159/000334718. Epub 2011 Dec 
      30.


PMID- 22212264
OWN - NLM
STAT- MEDLINE
DCOM- 20120501
LR  - 20170126
IS  - 0022-4707 (Print)
IS  - 0022-4707 (Linking)
VI  - 51
IP  - 4
DP  - 2011 Dec
TI  - Efficacy of a multimodal therapeutic exercise program in shellfish gatherers for 
      the prevention of musculoskeletal disorders: a quasi-experimental study.
PG  - 616-24
AB  - AIM: Aim of the present study was to determine the efficacy of a therapeutic
      exercise program to modify the muscular endurance of the trunk, the localization 
      and intensity of musculoskeletal pain, fear-avoidance beliefs, perceived change
      after the treatment and satisfaction. METHODS: The present study has a
      quasi-experimental design (N.=19) with measurements taken before and after 16
      sessions. The measures included: trunk extensors and flexors endurance,
      localization and intensity of pain and fear avoidance behavior. At the end of the
      program the perception of changes at musculoskeletal level and satisfaction were 
      also obtained. Statistical analysis was carried out using Student's T-test for
      paired data, Wilcoxon's test and McNemar's test. The study was approved by the
      Ethics Committee and the patients gave their informed consent. RESULTS: The 94%
      were women with a mean age of 58 years. The 42.1% had musculoskeletal pain, with 
      the most frequent locations being the lower back, neck and shoulder regions. A
      significant increase in the muscular endurance of the trunk extensors and flexors
      (in seconds) was detected; (67.1+/-42 vs. 96.1+/-55.2) (P=0.005) and (28.2+/-18.3
      vs. 67.8+/-41.1) (P=0.000), respectively. A decrease that was close to
      statistical significance (P=0.19) was observed in the score on the FABQ
      (53.9+/-18.8 vs. 48+/-19.7). The prevalence of lower back pain (84.2% vs. 47.4%; 
      P=0.016) and upper back pain (42.1% vs. 10.5%; P=0.031) decreased significantly
      after the treatment. The 78.4% had improved and 89.5% were very satisfied with
      the treatment. CONCLUSION: The treatment increased the muscular endurance of both
      the trunk extensors and flexors. A decrease in the prevalence of lower back,
      upper back and neck pain was observed. The perceived change and satisfaction were
      high.
FAU - Rodriguez-Romero, B
AU  - Rodriguez-Romero B
AD  - Department of Physical Therapy, University of A Coruna, Coruna, Spain.
      bear@udc.es
FAU - Martinez-Rodriguez, A
AU  - Martinez-Rodriguez A
FAU - Pita-Fernandez, S
AU  - Pita-Fernandez S
FAU - Riveiro-Temprano, S
AU  - Riveiro-Temprano S
FAU - Carballo, L
AU  - Carballo L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Italy
TA  - J Sports Med Phys Fitness
JT  - The Journal of sports medicine and physical fitness
JID - 0376337
SB  - IM
MH  - Avoidance Learning
MH  - *Exercise Therapy/psychology
MH  - Fear/psychology
MH  - Female
MH  - *Food Industry
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Muscle, Skeletal/physiology
MH  - Musculoskeletal Diseases/*prevention & control/psychology
MH  - Musculoskeletal Pain/therapy
MH  - Occupational Diseases/*prevention & control/psychology
MH  - Physical Endurance
MH  - *Shellfish
MH  - Torso/physiology
EDAT- 2012/01/04 06:00
MHDA- 2012/05/02 06:00
CRDT- 2012/01/04 06:00
PHST- 2012/01/04 06:00 [entrez]
PHST- 2012/01/04 06:00 [pubmed]
PHST- 2012/05/02 06:00 [medline]
AID - R40113320 [pii]
PST - ppublish
SO  - J Sports Med Phys Fitness. 2011 Dec;51(4):616-24.


PMID- 22212258
OWN - NLM
STAT- MEDLINE
DCOM- 20120501
LR  - 20170126
IS  - 0022-4707 (Print)
IS  - 0022-4707 (Linking)
VI  - 51
IP  - 4
DP  - 2011 Dec
TI  - Effects of relative age on physical and physiological performance characteristics
      in youth soccer.
PG  - 571-5
AB  - AIM: In youth sport, birth-date positioning of performers has significant
      implications for future success. This phenomenon is particularly evident in
      soccer and is identified as the "Relative Age Effect" (RAE). To date, limited
      work has been conducted into the RAE from a laboratory setting. METHODS: Subjects
      completed a modified cycling intermittent sprint protocol (mCISP) of 15, 6 s
      sprints against a resistance of 7.5%.body mass, interspersed with 120 s active
      recovery. Nineteen (male) athletes (mean+/-SD) age 14.2+/-0.7 y; height 164+/-7.9
      cm and body mass 54+/-8.7 kg participated and were separated into six-month
      groups, Early-Born (EB) or Late-Born (LB) based on birth-month. Ethical approval 
      was granted by the University Ethics Committee. RESULTS: Statistically
      significant differences (P<0.05) were found between EB and LB peak power outputs 
      (PPO) and mean power outputs (MPO) (absolute and relative to body mass). EB
      subjects had significantly higher inter-sprint MPOs and PPOs for 15 and 13
      sprints respectively. Borderline significance was observed for height and fat
      free mass (P=0.11). CONCLUSION: The present study suggests EB individuals are
      often more physically and physiologically mature than LB counterparts.
FAU - Bliss, A
AU  - Bliss A
AD  - Chelsea School of Sport, University of Brighton, Eastbourne, UK.
      a.bliss2@brighton.ac.uk
FAU - Brickley, G
AU  - Brickley G
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - J Sports Med Phys Fitness
JT  - The Journal of sports medicine and physical fitness
JID - 0376337
SB  - IM
MH  - Adolescent
MH  - *Age Factors
MH  - Athletic Performance/*physiology
MH  - Exercise Test
MH  - Humans
MH  - Male
MH  - Soccer/*physiology
EDAT- 2012/01/04 06:00
MHDA- 2012/05/02 06:00
CRDT- 2012/01/04 06:00
PHST- 2012/01/04 06:00 [entrez]
PHST- 2012/01/04 06:00 [pubmed]
PHST- 2012/05/02 06:00 [medline]
AID - R40113325 [pii]
PST - ppublish
SO  - J Sports Med Phys Fitness. 2011 Dec;51(4):571-5.


PMID- 22212221
OWN - NLM
STAT- MEDLINE
DCOM- 20120508
LR  - 20220330
IS  - 1752-8062 (Electronic)
IS  - 1752-8054 (Linking)
VI  - 4
IP  - 6
DP  - 2011 Dec
TI  - Assessing research participants' perceptions of their clinical research
      experiences.
PG  - 403-13
LID - 10.1111/j.1752-8062.2011.00349.x [doi]
AB  - INTRODUCTION: Participants' perceptions of their research experiences provide
      valuable measures of ethical treatment, yet no validated instruments exist to
      measure these experiences. We conducted focus groups of research participants and
      professionals as the initial step in developing a validated instrument. METHODS: 
      Research participants enrolled in 12 focus groups, consisting of: (1) individuals
      with disorders undergoing interventions; (2) in natural history studies; or (3)
      healthy volunteers. Research professionals participated in six separate groups
      of: (1) institutional review board members, ethicists, and Research Subject
      Advocates; (2) research nurses/coordinators; or (3) investigators. Focus groups
      used standard methodologies. RESULTS: Eighty-five participants and 29
      professionals enrolled at eight academic centers. Altruism and personal relevance
      of the research were commonly identified motivators; financial compensation was
      less commonly mentioned. Participants were satisfied with informed consent
      processes but disappointed if not provided test results, or study outcomes.
      Positive relationships with research teams were valued highly. Research
      professionals were concerned about risks, undue influence, and informed consent. 
      CONCLUSIONS: Participants join studies for varied, complex reasons, notably
      altruism and personal relevance. They value staff relationships, health gains,
      new knowledge, and compensation, and expect professionalism and good
      organization. On the basis of these insights, we propose specific actions to
      enhance participant recruitment, retention, and satisfaction.
CI  - (c) 2011 Wiley Periodicals, Inc.
FAU - Kost, Rhonda G
AU  - Kost RG
AD  - The Rockefeller University, New York, New York, USA. kostr@mail.rockefeller.edu
FAU - Lee, Laura M
AU  - Lee LM
FAU - Yessis, Jennifer
AU  - Yessis J
FAU - Coller, Barry S
AU  - Coller BS
FAU - Henderson, David K
AU  - Henderson DK
CN  - Research Participant Perception Survey Focus Group Subcommittee
LA  - eng
GR  - UL1 TR000043/TR/NCATS NIH HHS/United States
GR  - UL1RR024143/RR/NCRR NIH HHS/United States
GR  - UL1 RR024143/RR/NCRR NIH HHS/United States
GR  - S07 RR018141/RR/NCRR NIH HHS/United States
GR  - UL1 RR025755/RR/NCRR NIH HHS/United States
GR  - S07 RR18141/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20111107
PL  - United States
TA  - Clin Transl Sci
JT  - Clinical and translational science
JID - 101474067
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomedical Research/*methods
MH  - Ethics Committees, Research
MH  - Female
MH  - Focus Groups
MH  - Humans
MH  - Informed Consent
MH  - Male
MH  - Middle Aged
MH  - *Patient Participation
MH  - Patient Satisfaction
MH  - Patient Selection
MH  - Perception
MH  - Research Design
PMC - PMC3640854
MID - NIHMS446365
IR  - Needler N
FIR - Needler, Nancy
IR  - Dozier A
FIR - Dozier, Ann
IR  - Larson J
FIR - Larson, Jean
IR  - Britt S
FIR - Britt, Shelley
IR  - Alfano S
FIR - Alfano, Sandra
IR  - D'Agostino G
FIR - D'Agostino, Gina
IR  - Hahn C
FIR - Hahn, Cynthia
IR  - Tracey K
FIR - Tracey, Kevin
IR  - Saltzman A
FIR - Saltzman, Andrea
IR  - Cagliero E
FIR - Cagliero, Enrico
IR  - Jenckes M
FIR - Jenckes, Mollie
IR  - Dan F
FIR - Dan, Ford
IR  - Margatic S
FIR - Margatic, Susan
EDAT- 2012/01/04 06:00
MHDA- 2012/05/09 06:00
CRDT- 2012/01/04 06:00
PHST- 2012/01/04 06:00 [entrez]
PHST- 2012/01/04 06:00 [pubmed]
PHST- 2012/05/09 06:00 [medline]
AID - 10.1111/j.1752-8062.2011.00349.x [doi]
PST - ppublish
SO  - Clin Transl Sci. 2011 Dec;4(6):403-13. doi: 10.1111/j.1752-8062.2011.00349.x.
      Epub 2011 Nov 7.


PMID- 22212044
OWN - NLM
STAT- MEDLINE
DCOM- 20120504
LR  - 20130516
IS  - 1745-8315 (Electronic)
IS  - 0020-7578 (Linking)
VI  - 92
IP  - 6
DP  - 2011 Dec
TI  - Some thoughts on the diffusion of psychoanalysis: the group dimension, ethics and
      the sense of identity.
PG  - 1603-16
LID - 10.1111/j.1745-8315.2011.00486.x [doi]
AB  - In this paper the author questions some of the ways in which psychoanalysis is
      passed on to the wider public, one of which is sometimes evocative of the sales
      promotion of a consumer product in contemporary society. This methodology does
      not give sufficiently deep prior thought to the eventual consequences of side
      effects. The detailed exposition of clinical cases, for example, raises sensitive
      ethical issues, even when anonymity is preserved. Although it is true that making
      information about Freud's theories more widely available may indeed encourage
      people to think about training as psychoanalysts, it is noticeable that this
      process is sometimes considered to be a form of training in itself. Some
      participants feel that acquiring a psychoanalytical vocabulary and reading
      clinical reports form a sufficient basis for practising thereafter as
      psychotherapists, both in institutional contexts and in private practice. The
      absence of group work on the part of the organizers might explain why closer
      study is not made of the methodologies of transmission and the different levels
      that it involves. This is sometimes due to the absence of a common object, formed
      within and by the group, and to the emergence of manic defences in the group.
CI  - Copyright (c) 2011 Institute of Psychoanalysis.
FAU - Namer, Albert
AU  - Namer A
AD  - albert.namer@wanadoo.fr
LA  - eng
PT  - Journal Article
DEP - 20111017
PL  - England
TA  - Int J Psychoanal
JT  - The International journal of psycho-analysis
JID - 2985179R
SB  - IM
CIN - Int J Psychoanal. 2013 Apr;94(2):373-4. PMID: 23560909
MH  - Humans
MH  - *Psychoanalysis
MH  - Psychoanalytic Theory
MH  - *Psychoanalytic Therapy
EDAT- 2012/01/04 06:00
MHDA- 2012/05/05 06:00
CRDT- 2012/01/04 06:00
PHST- 2012/01/04 06:00 [entrez]
PHST- 2012/01/04 06:00 [pubmed]
PHST- 2012/05/05 06:00 [medline]
AID - 10.1111/j.1745-8315.2011.00486.x [doi]
PST - ppublish
SO  - Int J Psychoanal. 2011 Dec;92(6):1603-16. doi: 10.1111/j.1745-8315.2011.00486.x. 
      Epub 2011 Oct 17.


PMID- 22211472
OWN - NLM
STAT- MEDLINE
DCOM- 20120806
LR  - 20181201
IS  - 1365-2648 (Electronic)
IS  - 0309-2402 (Linking)
VI  - 68
IP  - 6
DP  - 2012 Jun
TI  - Nurses' decision-making in cases of physical restraint: a synthesis of
      qualitative evidence.
PG  - 1198-210
LID - 10.1111/j.1365-2648.2011.05909.x [doi]
AB  - AIM: This article is a report of a review that aimed to synthesize the available 
      qualitative evidence on nurses' decision-making in cases of physical restraint.
      BACKGROUND: The use of physical restraint in acute and residential healthcare
      facilities is a widespread practice in many countries. Decisions about the use of
      physical restraints are complex and ethically laden. The lack of evidence
      supporting the use of physical restraints, the negative consequences of restraint
      for patients, and the low availability of alternatives obviously complicate the
      decision-making. DATA SOURCES: Research papers published between January 1990 and
      January 2010 were identified in Cinahl, Embase, Medline, PsycInfo and Web of
      Science. REVIEW METHODS: A systematic review was carried out to obtain a
      meta-synthesis of qualitative evidence. The process of meta-synthesis was
      supported by the Joanna Briggs Institute's guidelines. FINDINGS: The
      decision-making of nurses dealing with the use of physical restraints is a
      complex trajectory primarily focused on safety. However, thoughtful
      decision-making requires nurses to carefully balance different options and
      associated ethical values. The decision-making process of nurses is influenced by
      both nurse- and context-related factors. CONCLUSIONS: This review provides a
      deeper understanding of nurses' decision-making process on the use of physical
      restraints. Context- and nurse-related factors can hinder nurses from making an
      ethical decision on the appropriate use of physical restraints. There is an
      urgent need to stimulate and educate nurses to arrive at an appropriate decision 
      about the use of physical restraints.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Goethals, Sabine
AU  - Goethals S
AD  - Department of Nursing, Catholic University College, Ghent, Belgium.
      sabine.goethals@kahosl.be
FAU - Dierckx de Casterle, Bernadette
AU  - Dierckx de Casterle B
FAU - Gastmans, Chris
AU  - Gastmans C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20111228
PL  - England
TA  - J Adv Nurs
JT  - Journal of advanced nursing
JID - 7609811
SB  - IM
MH  - Databases, Bibliographic
MH  - *Decision Making
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Nursing Research
MH  - Nursing Staff, Hospital/*ethics/psychology
MH  - Restraint, Physical/*ethics
MH  - Safety Management/*ethics
EDAT- 2012/01/04 06:00
MHDA- 2012/08/07 06:00
CRDT- 2012/01/04 06:00
PHST- 2012/01/04 06:00 [entrez]
PHST- 2012/01/04 06:00 [pubmed]
PHST- 2012/08/07 06:00 [medline]
AID - 10.1111/j.1365-2648.2011.05909.x [doi]
PST - ppublish
SO  - J Adv Nurs. 2012 Jun;68(6):1198-210. doi: 10.1111/j.1365-2648.2011.05909.x. Epub 
      2011 Dec 28.


PMID- 22211446
OWN - NLM
STAT- MEDLINE
DCOM- 20130515
LR  - 20120711
IS  - 1365-2648 (Electronic)
IS  - 0309-2402 (Linking)
VI  - 68
IP  - 8
DP  - 2012 Aug
TI  - Perspectives on peritoneal dialysis at home: implications for the management of a
      chronic condition. A study protocol.
PG  - 1847-57
LID - 10.1111/j.1365-2648.2011.05907.x [doi]
AB  - AIM: This article is a report of a study protocol designed to explore the
      experience of home peritoneal dialysis from the perspectives of individuals,
      their families and healthcare professionals in the United Kingdom. BACKGROUND:
      Peritoneal dialysis is an established life-saving treatment for end-stage renal
      disease. This daily treatment is undertaken at home, and nurses play a key role
      in supporting people with their dialysis and monitoring their condition. Although
      peritoneal dialysis is known to have an impact on peoples' quality of life, few
      studies have explored peoples' experiences of undertaking this treatment at home,
      nor investigated their families' and health professionals' perspectives. DESIGN: 
      An ethnographic study is proposed, which will use in-depth interviews and
      non-participant observations with people who are undertaking peritoneal dialysis 
      at home in the United Kingdom. Family members and healthcare professionals
      closely involved with these individuals will also be interviewed. The local
      ethics and governance committees approved this study in November 2010.
      DISCUSSION: It is anticipated that the study's findings will provide a detailed
      insight into the impact of peritoneal dialysis on individuals and their families.
      The findings will inform local strategies and/or interventions that could improve
      peoples' experiences of undertaking this treatment. Furthermore, the
      appropriateness of ethnographic methodology to examine individuals' and families'
      experiences of home treatments will be considered.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Baillie, Jessica
AU  - Baillie J
AD  - School of Nursing and Midwifery Studies, Cardiff University, UK.
      bailliej2@cf.ac.uk
FAU - Lankshear, Annette
AU  - Lankshear A
FAU - Featherstone, Katie
AU  - Featherstone K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20111228
PL  - England
TA  - J Adv Nurs
JT  - Journal of advanced nursing
JID - 7609811
SB  - IM
MH  - Anthropology, Cultural
MH  - Attitude to Health
MH  - *Cost of Illness
MH  - *Family Health
MH  - *Home Care Services
MH  - Humans
MH  - Kidney Failure, Chronic/nursing/*therapy
MH  - Nursing Research/methods
MH  - Peritoneal Dialysis/*nursing/psychology
MH  - Qualitative Research
MH  - Quality of Life
MH  - Self Care/*psychology
MH  - Wales
EDAT- 2012/01/04 06:00
MHDA- 2013/05/17 06:00
CRDT- 2012/01/04 06:00
PHST- 2012/01/04 06:00 [entrez]
PHST- 2012/01/04 06:00 [pubmed]
PHST- 2013/05/17 06:00 [medline]
AID - 10.1111/j.1365-2648.2011.05907.x [doi]
PST - ppublish
SO  - J Adv Nurs. 2012 Aug;68(8):1847-57. doi: 10.1111/j.1365-2648.2011.05907.x. Epub
      2011 Dec 28.


PMID- 22211377
OWN - NLM
STAT- MEDLINE
DCOM- 20120604
LR  - 20181201
IS  - 1539-6924 (Electronic)
IS  - 0272-4332 (Linking)
VI  - 32
IP  - 2
DP  - 2012 Feb
TI  - Why income inequality indexes do not apply to health risks.
PG  - 192-6; author reply 197-9
LID - 10.1111/j.1539-6924.2011.01756.x [doi]
AB  - Several recent papers have sought to apply inequality measures from economics,
      such as the Atkinson Index (AI) for inequality of income distributions, to
      compare the risk inequality of different mortality risk distributions in an
      effort to help promote efficiency and environmental justice in pollution-reducing
      interventions. Closer analysis suggests that such applications are neither
      logically coherent nor necessarily ethically desirable. Risk inequality
      comparisons should be based on axioms that apply to probabilistic risks, and
      should consider the multidimensional and time-varying nature of individual and
      community risks in order to increase efficiency and justice over time and
      generations. In light of the limitations of the AI applied to mortality risk
      distributions, it has not been demonstrated to have ethical or practical value in
      helping policymakers to identify air pollution management interventions that
      reduce (or minimize) risk and risk inequity.
CI  - (c) 2011 Society for Risk Analysis.
FAU - Cox, Louis Anthony Jr
AU  - Cox LA Jr
LA  - eng
PT  - Letter
PT  - Comment
DEP - 20111229
PL  - United States
TA  - Risk Anal
JT  - Risk analysis : an official publication of the Society for Risk Analysis
JID - 8109978
RN  - 0 (Air Pollutants)
SB  - IM
CON - Risk Anal. 2011 Jun;31(6):908-22. PMID: 21615761
MH  - *Air Pollutants
MH  - *Environmental Policy
MH  - Humans
MH  - *Social Justice
EDAT- 2012/01/04 06:00
MHDA- 2012/06/05 06:00
CRDT- 2012/01/04 06:00
PHST- 2012/01/04 06:00 [entrez]
PHST- 2012/01/04 06:00 [pubmed]
PHST- 2012/06/05 06:00 [medline]
AID - 10.1111/j.1539-6924.2011.01756.x [doi]
PST - ppublish
SO  - Risk Anal. 2012 Feb;32(2):192-6; author reply 197-9. doi:
      10.1111/j.1539-6924.2011.01756.x. Epub 2011 Dec 29.


PMID- 22211210
OWN - NLM
STAT- MEDLINE
DCOM- 20120424
LR  - 20170123
IS  - 1557-9700 (Electronic)
IS  - 1075-2730 (Linking)
VI  - 62
IP  - 11
DP  - 2011 Nov
TI  - A randomized controlled comparison of seclusion and mechanical restraint in
      inpatient settings.
PG  - 1310-7
LID - 10.1176/ps.62.11.pss6211_1310 [doi]
AB  - OBJECTIVE: No evidence is available on the relative restrictiveness of seclusion 
      and mechanical restraint, although guidelines recommend use of the least
      restrictive intervention. This study compared the restrictiveness of these
      interventions from patients' point of view. METHODS: Data were collected from
      three general psychiatric admission units in South Germany. A total of 102
      patients with schizophrenia, an affective disorder, or a personality disorder
      were included in a comprehensive cohort study with optional randomization.
      Restrictions of human rights as measured by the Coercion Experience Scale (CES)
      were the primary outcome variable. Possible total scores range from 1 to 5, with 
      higher scores indicating a higher level of restriction. RESULTS: Twenty-six
      patients were randomly assigned to seclusion (N=12) or mechanical restraint
      (N=14). A total of 76 were excluded from randomization and included in the cohort
      arms (48 experienced seclusion, and 28 experienced mechanical restraint). No
      difference in mean CES total scores was found between the randomly assigned
      patients after they experienced seclusion or mechanical restraint (seclusion
      median score=1.88 [range 1.24-4.24]; restraint median score=2.14 [range
      1.28-4.00]). When randomly assigned patients and patients in the cohort arms were
      considered as a group, no significant difference in CES scores was found
      (seclusion median score=.40, [range 1.1-4.2]; restraint median score=2.59 [range 
      1.1-4.0]). CONCLUSIONS: The results do not provide evidence for using one
      intervention rather than the other. Clinical decisions should take into account
      patients' preferences. Randomized controlled trials of coercive interventions are
      feasible. Such studies contribute to the development of ethical and
      evidence-based guidelines.
FAU - Bergk, Jan
AU  - Bergk J
AD  - Department of Psychiatry, University of Ulm, Ravensburg, Germany.
FAU - Einsiedler, Beate
AU  - Einsiedler B
FAU - Flammer, Erich
AU  - Flammer E
FAU - Steinert, Tilman
AU  - Steinert T
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Psychiatr Serv
JT  - Psychiatric services (Washington, D.C.)
JID - 9502838
SB  - IM
MH  - Adult
MH  - Aggression/psychology
MH  - Coercion
MH  - Cohort Studies
MH  - Evidence-Based Practice/ethics
MH  - Fear/psychology
MH  - Female
MH  - Germany
MH  - Hospitals, Psychiatric
MH  - Human Rights/*psychology
MH  - Humans
MH  - Male
MH  - Mental Disorders/psychology/*therapy
MH  - Middle Aged
MH  - Patient Isolation/ethics/*psychology
MH  - Patient Preference
MH  - Restraint, Physical/ethics/*psychology
MH  - Young Adult
EDAT- 2012/01/03 06:00
MHDA- 2012/04/25 06:00
CRDT- 2012/01/03 06:00
PHST- 2012/01/03 06:00 [entrez]
PHST- 2012/01/03 06:00 [pubmed]
PHST- 2012/04/25 06:00 [medline]
AID - 10.1176/ps.62.11.pss6211_1310 [doi]
PST - ppublish
SO  - Psychiatr Serv. 2011 Nov;62(11):1310-7. doi: 10.1176/ps.62.11.pss6211_1310.


PMID- 22211117
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220409
IS  - 1553-6947 (Print)
IS  - 1553-6947 (Linking)
VI  - 8
IP  - 2
DP  - 2011 Fall
TI  - Mental Health Stigma: Society, Individuals, and the Profession.
PG  - 41-416
AB  - Mental health stigma operates in society, is internalized by individuals, and is 
      attributed by health professionals. This ethics-laden issue acts as a barrier to 
      individuals who may seek or engage in treatment services. The dimensions, theory,
      and epistemology of mental health stigma have several implications for the social
      work profession.
FAU - Ahmedani, Brian K
AU  - Ahmedani BK
AD  - School of Social Work, Michigan State University, bahmeda1@hfhs.org.
LA  - eng
GR  - K05 DA015799/DA/NIDA NIH HHS/United States
GR  - T32 DA021129/DA/NIDA NIH HHS/United States
GR  - T32 DA021129-03/DA/NIDA NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - J Soc Work Values Ethics
JT  - Journal of social work values and ethics
JID - 101292628
PMC - PMC3248273
MID - NIHMS342711
EDAT- 2012/01/03 06:00
MHDA- 2012/01/03 06:01
CRDT- 2012/01/03 06:00
PHST- 2012/01/03 06:00 [entrez]
PHST- 2012/01/03 06:00 [pubmed]
PHST- 2012/01/03 06:01 [medline]
PST - ppublish
SO  - J Soc Work Values Ethics. 2011 Fall;8(2):41-416.


PMID- 22210936
OWN - NLM
STAT- MEDLINE
DCOM- 20120207
LR  - 20211021
IS  - 0008-5286 (Print)
IS  - 0008-5286 (Linking)
VI  - 52
IP  - 7
DP  - 2011 Jul
TI  - An ethicist's commentary on animal intelligence and animal welfare.
PG  - 702, 704
FAU - Rollin, Bernard E
AU  - Rollin BE
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Vet J
JT  - The Canadian veterinary journal = La revue veterinaire canadienne
JID - 0004653
SB  - IM
MH  - Animal Welfare/*ethics
MH  - Animals
MH  - *Human-Animal Bond
MH  - Humans
MH  - *Moral Development
MH  - Veterinary Medicine/*ethics
PMC - PMC3119234
EDAT- 2012/01/03 06:00
MHDA- 2012/02/09 06:00
CRDT- 2012/01/03 06:00
PHST- 2012/01/03 06:00 [entrez]
PHST- 2012/01/03 06:00 [pubmed]
PHST- 2012/02/09 06:00 [medline]
PST - ppublish
SO  - Can Vet J. 2011 Jul;52(7):702, 704.


PMID- 22208165
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1687-9856 (Electronic)
IS  - 1687-9848 (Linking)
VI  - 2011
IP  - 1
DP  - 2011 Dec 30
TI  - Overcoming burdens in the regulation of clinical research in children.
      Proceedings of a consensus conference, in historical context.
PG  - 19
LID - 10.1186/1687-9856-2011-19 [doi]
AB  - BACKGROUND: Many investigators are concerned that the modes of implementation and
      enforcement of the federal regulations designed to protect children are unduly
      impeding pediatric clinical research. OBJECTIVE: To assess regulatory impediments
      to clinical research involving children and to develop recommendations to
      ameliorate them. PARTICIPANTS: The Pediatric Endocrine Society and The Endocrine 
      Society convened a consensus conference involving experts and stakeholders in
      patient-oriented research involving children and adolescents in 2008. CONSENSUS
      PROCESS: Following presentations that reviewed problematic issues around key
      regulations, participants divided into working groups to develop potential
      solutions that could be adopted at local and federal levels. Presentations to the
      full assembly were then debated. A writing committee then drafted a summary of
      the discussions and main conclusions, placing them in historical context, and
      submitted it to all participants for comment with the aim of developing
      consensus. CONCLUSIONS: Recommendations designed to facilitate the ethical
      conduct of research involving children addressed the interpretation of ambiguous 
      regulatory terms such as "minimal risk" and "condition" and called for the
      development by professional societies of best practice primers for common
      research procedures that would be informative to both investigators and
      institutional review boards. A call was issued for improved guidance from the
      Office for Human Research Protections and Food and Drug Administration as well as
      for the development by professional societies of a process to monitor progress in
      improving human subject research regulation. Finally, a need for systematic
      research to define the nature and extent of institutional obstacles to pediatric 
      research was recognized.
FAU - Levine, Robert J
AU  - Levine RJ
AD  - The University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA.
      robros@peds.bsd.uchicago.edu.
FAU - Genel, Myron
AU  - Genel M
FAU - Cuttler, Leona
AU  - Cuttler L
FAU - Becker, Dorothy J
AU  - Becker DJ
FAU - Nieman, Lynnette
AU  - Nieman L
FAU - Rosenfield, Robert L
AU  - Rosenfield RL
LA  - eng
PT  - Journal Article
DEP - 20111230
PL  - England
TA  - Int J Pediatr Endocrinol
JT  - International journal of pediatric endocrinology
JID - 101516111
PMC - PMC3276425
EDAT- 2012/01/03 06:00
MHDA- 2012/01/03 06:01
CRDT- 2012/01/03 06:00
PHST- 2011/12/05 00:00 [received]
PHST- 2011/12/30 00:00 [accepted]
PHST- 2012/01/03 06:00 [entrez]
PHST- 2012/01/03 06:00 [pubmed]
PHST- 2012/01/03 06:01 [medline]
AID - 1687-9856-2011-19 [pii]
AID - 10.1186/1687-9856-2011-19 [doi]
PST - epublish
SO  - Int J Pediatr Endocrinol. 2011 Dec 30;2011(1):19. doi: 10.1186/1687-9856-2011-19.


PMID- 27909388
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1050-8422 (Print)
IS  - 1050-8422 (Linking)
VI  - 22
IP  - 1
DP  - 2012
TI  - What Should We Do When Participants Report Dangerous Drinking? The Impact of
      Personalized Letters Versus General Pamphlets as a Function of Sex and Controlled
      Orientation.
PG  - 1-15
AB  - Research in which participants report potentially dangerous health-related
      behaviors raises ethical and professional questions about what to do with that
      information. Policies and laws regarding reportable behaviors vary across states 
      and Institutional Review Boards (IRB). In alcohol research, IRBs often require
      researchers to respond to participants who report dangerous drinking practices.
      Researchers have little guidance regarding how best to respond in such cases.
      Personalized feedback or general nonpersonalized information may prove
      differentially effective as a function of gender and/or level of
      self-determination. This study evaluated response strategies for reducing peak
      blood alcohol concentration (BAC) among participants reporting dangerous BACs
      (>/= .35%) in the context of a two-year longitudinal intervention trial with 818 
      heavy drinking college students. After each assessment, participants who reported
      drinking to estimated BACs at or greater than .35% were sent either a
      personalized letter expressing concern and indicating their reported BAC or a
      nonpersonalized pamphlet that included general information about alcohol and
      other substances, referral information, and a BAC handout. Hierarchical linear
      modeling results revealed that both strategies were associated with reduced peak 
      BAC when controlling for previous BAC. The personalized letter was more effective
      for women and for students who tend to regulate their behavior based on others'
      expectations and contingencies in the environment. This research provides some
      guidance for researchers considering appropriate responses to participants who
      report dangerous health behavior in the context of a research trial.
FAU - Neighbors, Clayton
AU  - Neighbors C
AD  - Department of Psychology, University of Houston.
FAU - Pedersen, Eric R
AU  - Pedersen ER
AD  - Department of Psychology, University of Washington.
FAU - Kaysen, Debra
AU  - Kaysen D
AD  - Department of Psychiatry and Behavioral Sciences, University of Washington.
FAU - Kulesza, Magdalena
AU  - Kulesza M
AD  - Department of Psychology, Louisiana State University.
FAU - Walter, Theresa
AU  - Walter T
AD  - Department of Psychiatry and Behavioral Sciences, University of Washington.
LA  - eng
GR  - R01 AA014576/AA/NIAAA NIH HHS/United States
PT  - Journal Article
DEP - 20111115
PL  - United States
TA  - Ethics Behav
JT  - Ethics & behavior
JID - 9102086
PMC - PMC5127270
MID - NIHMS799532
OTO - NOTNLM
OT  - alcohol
OT  - ethics
OT  - human subjects
OT  - self-determination
EDAT- 2012/01/01 00:00
MHDA- 2012/01/01 00:01
CRDT- 2016/12/03 06:00
PHST- 2016/12/03 06:00 [entrez]
PHST- 2012/01/01 00:00 [pubmed]
PHST- 2012/01/01 00:01 [medline]
AID - 10.1080/10508422.2012.638817 [doi]
PST - ppublish
SO  - Ethics Behav. 2012;22(1):1-15. doi: 10.1080/10508422.2012.638817. Epub 2011 Nov
      15.


PMID- 26069396
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 0948-3349 (Print)
IS  - 0948-3349 (Linking)
VI  - 17
IP  - 3
DP  - 2012
TI  - Life cycle assessment of aquaculture systems-a review of methodologies.
PG  - 304-313
AB  - PURPOSE: As capture fishery production has reached its limits and global demand
      for aquatic products is still increasing, aquaculture has become the world's
      fastest growing animal production sector. In attempts to evaluate the
      environmental consequences of this rapid expansion, life cycle assessment (LCA)
      has become a frequently used method. The present review of current peer-reviewed 
      literature focusing on LCA of aquaculture systems is intended to clarify the
      methodological choices made, identify possible data gaps, and provide
      recommendations for future development within this field of research. The results
      of this review will also serve as a start-up activity of the EU FP7 SEAT
      (Sustaining Ethical Aquaculture Trade) project, which aims to perform several LCA
      studies on aquaculture systems in Asia over the next few years. METHODS: From a
      full analysis of methodology in LCA, six phases were identified to differ the
      most amongst ten peer-reviewed articles and two PhD theses (functional unit,
      system boundaries, data and data quality, allocation, impact assessment methods, 
      interpretation methods). Each phase is discussed with regards to differences
      amongst the studies, current LCA literature followed by recommendations where
      appropriate. The conclusions and recommendations section reflects on
      aquaculture-specific scenarios as well as on some more general issues in LCA.
      RESULTS: Aquaculture LCAs often require large system boundaries, including
      fisheries, agriculture, and livestock production systems from around the globe.
      The reviewed studies offered limited coverage of production in developing
      countries, low-intensity farming practices, and non-finfish species, although
      most farmed aquatic products originate from a wide range of farming practices in 
      Asia. Apart from different choices of functional unit, system boundaries and
      impact assessment methods, the studies also differed in their choice of
      allocation factors and data sourcing. Interpretation of results also differed
      amongst the studies, and a number of methodological choices were identified
      influencing the outcomes. CONCLUSIONS AND RECOMMENDATIONS: Efforts should be made
      to increase transparency to allow the results to be reproduced, and to construct 
      aquaculture related database(s). More extensive data reporting, including
      environmental flows, within the greater field of LCA could be achieved, without
      compromising the focus of studies, by providing supporting information to
      articles and/or reporting only ID numbers from background databases. More
      research is needed into aquaculture in Asia based on the latest progress made by 
      the LCA community.
FAU - Henriksson, Patrik J G
AU  - Henriksson PJ
AD  - Institute of Environmental Sciences (CML), Department of Industrial Ecology,
      Leiden University, 2333 CC Leiden, the Netherlands.
FAU - Guinee, Jeroen B
AU  - Guinee JB
AD  - Institute of Environmental Sciences (CML), Department of Industrial Ecology,
      Leiden University, 2333 CC Leiden, the Netherlands.
FAU - Kleijn, Rene
AU  - Kleijn R
AD  - Institute of Environmental Sciences (CML), Department of Industrial Ecology,
      Leiden University, 2333 CC Leiden, the Netherlands.
FAU - de Snoo, Geert R
AU  - de Snoo GR
AD  - Institute of Environmental Sciences (CML), Department of Industrial Ecology,
      Leiden University, 2333 CC Leiden, the Netherlands.
LA  - eng
PT  - Review
DEP - 20111224
PL  - Germany
TA  - Int J Life Cycle Assess
JT  - The international journal of life cycle assessment
JID - 101659490
PMC - PMC4456070
OTO - NOTNLM
OT  - Aquaculture
OT  - Fish
OT  - Food
OT  - LCA
OT  - Life cycle assessment
OT  - Review
OT  - Seafood
EDAT- 2012/01/01 00:00
MHDA- 2012/01/01 00:01
CRDT- 2015/06/13 06:00
PHST- 2011/02/18 00:00 [received]
PHST- 2011/12/09 00:00 [accepted]
PHST- 2015/06/13 06:00 [entrez]
PHST- 2012/01/01 00:00 [pubmed]
PHST- 2012/01/01 00:01 [medline]
AID - 10.1007/s11367-011-0369-4 [doi]
AID - 369 [pii]
PST - ppublish
SO  - Int J Life Cycle Assess. 2012;17(3):304-313. doi: 10.1007/s11367-011-0369-4. Epub
      2011 Dec 24.


PMID- 24089650
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131003
LR  - 20211021
IS  - 2090-9187 (Print)
IS  - 2090-9195 (Linking)
VI  - 2012
DP  - 2012
TI  - Ethical aspects of blood donors and the recipients of their blood.
PG  - 606753
LID - 10.1155/2012/606753 [doi]
AB  - To date medical care is inextricable based on blood donors and blood products.
      The continuing increase and intensification of tests and guidelines also results 
      in a change in deferral and abnormal test results. Donors and recipients of their
      blood are faced with this information and are confronted with a kaleidoscope of
      thoughts and emotions. The discussion with respect to paid versus nonpaid
      donation is not new, but other aspects are less often discussed. We describe
      these other aspects for donors and recipients of their blood and hope to open the
      ethical discussion; if and to what extent we should have limits?
FAU - van den Burg, P J M
AU  - van den Burg PJ
AD  - Sanquin blood Supply, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands.
FAU - Magnussen, K
AU  - Magnussen K
LA  - eng
PT  - Journal Article
DEP - 20111229
PL  - United States
TA  - J Blood Transfus
JT  - Journal of blood transfusion
JID - 101613231
PMC - PMC3777254
EDAT- 2012/01/01 00:00
MHDA- 2012/01/01 00:01
CRDT- 2013/10/04 06:00
PHST- 2011/10/05 00:00 [received]
PHST- 2011/12/13 00:00 [revised]
PHST- 2011/12/27 00:00 [accepted]
PHST- 2013/10/04 06:00 [entrez]
PHST- 2012/01/01 00:00 [pubmed]
PHST- 2012/01/01 00:01 [medline]
AID - 10.1155/2012/606753 [doi]
PST - ppublish
SO  - J Blood Transfus. 2012;2012:606753. doi: 10.1155/2012/606753. Epub 2011 Dec 29.


PMID- 24089647
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20211021
IS  - 2090-9187 (Print)
IS  - 2090-9195 (Linking)
VI  - 2012
DP  - 2012
TI  - Using basic ethical principles to evaluate safety efforts in transfusion
      medicine.
PG  - 407326
LID - 10.1155/2012/407326 [doi]
AB  - Pursuit of pharmaceutical purity of the blood in the bag has led to a shrinking
      donor base and a significantly more expensive product. Decisions regarding new
      infectious marker testing and donor deferrals have typically been made
      emphasizing decreasing one specific risk without considering the effect the
      intervention will have on the overall safety and availability of blood
      transfusion. Regulations have been formulated by governmental agencies with
      limited input from the medical community. The decision making process has lacked 
      risk benefit analyses and has not had the robustness associated with spirited
      discussions. Policies made in this manner may result in certain risks being
      decreased but can also have adverse unintended consequences. Being guided by the 
      ethical principles of nonmaleficence, beneficence, autonomy, and justice, we need
      to evaluate our actions in the context of overall blood safety rather than
      narrowly focusing on any one area.
FAU - Brooks, Jay P
AU  - Brooks JP
AD  - Department of Pathology, Immunology and Laboratory Medicine, College of Medicine,
      University of Florida, P.O. Box 100275, Gainesville, FL 32610-0275, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111207
PL  - United States
TA  - J Blood Transfus
JT  - Journal of blood transfusion
JID - 101613231
PMC - PMC3777255
EDAT- 2012/01/01 00:00
MHDA- 2012/01/01 00:01
CRDT- 2013/10/04 06:00
PHST- 2011/10/10 00:00 [received]
PHST- 2011/11/22 00:00 [accepted]
PHST- 2013/10/04 06:00 [entrez]
PHST- 2012/01/01 00:00 [pubmed]
PHST- 2012/01/01 00:01 [medline]
AID - 10.1155/2012/407326 [doi]
PST - ppublish
SO  - J Blood Transfus. 2012;2012:407326. doi: 10.1155/2012/407326. Epub 2011 Dec 7.


PMID- 22207332
OWN - NLM
STAT- MEDLINE
DCOM- 20121218
LR  - 20220408
IS  - 1460-2385 (Electronic)
IS  - 0931-0509 (Linking)
VI  - 27
IP  - 7
DP  - 2012 Jul
TI  - Timing of initiation of renal replacement therapy for acute kidney injury: a
      survey of nephrologists and intensivists in Canada.
PG  - 2761-7
LID - 10.1093/ndt/gfr740 [doi]
AB  - BACKGROUND: Little is known about factors that influence the timing of initiation
      of renal replacement therapy (RRT) for acute kidney injury (AKI). We sought to
      better describe these factors for Canadian physicians that prescribe RRT for AKI.
      METHODS: A web-based survey was conducted of physicians involved in the decision 
      to initiate RRT for critically ill patients in Canada. Participants were asked
      about the factors that prompt them to initiate RRT for AKI both directly and
      using scenario-based questions. RESULTS: Surveys completed by 180 physicians at
      32 different sites were included for analysis. Serum potassium level and severity
      of pulmonary edema were the most commonly utilized factors for deciding when RRT 
      should be started. For all clinical and laboratory factors inquired about, there 
      was wide variation in the minimum severity that prompted respondents to indicate 
      that they would initiate RRT. Additional factors that influenced the timing of
      initiation were the time-of-day that laboratory and clinical results became
      available, patient age and co-morbidity, responsiveness to a diuretic challenge
      and the specialty of the prescribing physician. Over 90% of respondents indicated
      that a randomized controlled trial to assess the optimal timing of initiation of 
      RRT for AKI is ethically justified. CONCLUSIONS: These results provide insight
      into clinical and laboratory factors that influence the timing of initiation of
      RRT for AKI and may aid in the design of future trials. While most clinicians
      consider the degree of hyperkalemia and pulmonary edema in deciding when to
      initiate RRT for AKI, there is a wide range of clinical practice, uncertainty
      regarding the optimal timing of initiation and enthusiasm for prospective
      interventional studies to address this topic.
FAU - Clark, Edward
AU  - Clark E
AD  - Kidney Research Centre, Ottawa Hospital Research Institute, University of Ottawa,
      Ottawa, Canada.
FAU - Wald, Ron
AU  - Wald R
FAU - Walsh, Michael
AU  - Walsh M
FAU - Bagshaw, Sean M
AU  - Bagshaw SM
CN  - Canadian Acute Kidney Injury (CANAKI) Investigators
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111229
PL  - England
TA  - Nephrol Dial Transplant
JT  - Nephrology, dialysis, transplantation : official publication of the European
      Dialysis and Transplant Association - European Renal Association
JID - 8706402
SB  - IM
MH  - *Acute Kidney Injury
MH  - Aged
MH  - Canada
MH  - *Critical Care
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Nephrology
MH  - *Physicians
MH  - *Renal Replacement Therapy
MH  - Time Factors
MH  - Treatment Outcome
IR  - B SM
FIR - B, S M
IR  - Barton J
FIR - Barton, Jim
IR  - C E
FIR - C, E
IR  - House AA
FIR - House, Andrew A
IR  - James MT
FIR - James, Matthew T
IR  - Levin A
FIR - Levin, Adeera
IR  - Moist L
FIR - Moist, Louise
IR  - Pannu N
FIR - Pannu, Neesh
IR  - W MW
FIR - W, M W
IR  - Wald R
FIR - Wald, Ron
EDAT- 2011/12/31 06:00
MHDA- 2012/12/19 06:00
CRDT- 2011/12/31 06:00
PHST- 2011/12/31 06:00 [entrez]
PHST- 2011/12/31 06:00 [pubmed]
PHST- 2012/12/19 06:00 [medline]
AID - gfr740 [pii]
AID - 10.1093/ndt/gfr740 [doi]
PST - ppublish
SO  - Nephrol Dial Transplant. 2012 Jul;27(7):2761-7. doi: 10.1093/ndt/gfr740. Epub
      2011 Dec 29.


PMID- 22206765
OWN - NLM
STAT- MEDLINE
DCOM- 20141112
LR  - 20191210
IS  - 1878-5883 (Electronic)
IS  - 0022-510X (Linking)
VI  - 311 Suppl 1
DP  - 2011 Dec
TI  - Review of methodological issues of clinical trials in multiple sclerosis.
PG  - S35-42
AB  - There are currently six approved disease-modifying therapies available to the
      physician for the treatment of multiple sclerosis. Their efficacy on clinical and
      radiological parameters has been demonstrated in Phase III pivotal clinical
      trials over the past two decades. Perceptions of the relative potency of these
      treatments have been driven principally by the response measured relative to a
      placebo group. However, efficacy comparisons between trials is of limited value
      because of differences in study methodology, in characteristics of the patient
      populations included, in the behaviour of the placebo group during the trial and 
      in the time at which the trial was conducted. Moreover, and most importantly, the
      assumption that the efficacy observed in clinical trial settings is the same as
      that achievable in everyday clinical practice is inevitably flawed. Impressions
      of the relative efficacy of two treatments may differ dramatically depending on
      whether absolute or relative differences with respect to placebo are compared.
      Randomised direct comparative trials are therefore the only objective way to
      evaluate the relative efficacy of two therapies. It is clear that
      between-treatment differences are difficult to quantify in short-term studies and
      require large numbers of patients. Long-term outcome is increasingly important to
      monitor in spite of the inherent methodological limitations in order to establish
      the safety profile of a potentially lifelong treatment. New disease-modifying
      treatments for multiple sclerosis will soon be available. Although these are
      eagerly awaited, their risk-benefit profile, and their place in therapy, will
      only be adequately understood once real-life and long-term use has been
      documented as well as it has been for current treatments. Over the last two
      decades, considerable advances have been made in the methodology of clinical
      trials in multiple sclerosis. Consensual standardised protocols have been
      designed and validated for Phase II and Phase III trials, with standardised
      definitions for short-term clinical and radiological outcome measures. The
      elaboration and implementation of this methodology were possible through
      international collaborations, and this has enabled extensive experience to be
      gained throughout the world. These trials have laid the foundation for an
      evidence-based medicine approach to the treatment of multiple sclerosis. Clinical
      trials in multiple sclerosis have to some extent become a victim of their own
      success, with more and more trials competing for a limited pool of patients and
      limited resources. Modern trials require large number of patients to generate
      adequate statistical power and this in turn entails recruitment in many countries
      across different continents. This increases the complexity and cost of the study,
      and contract research organisations now play a dominant role in the logistics and
      administration of these trials. The challenge in conducting trials on a global
      basis involving large numbers of countries is to ensure that this heterogeneity
      does not impinge on the reliability of the findings. This may happen due to
      differences in the patient populations included in different countries, access to
      or experience with methods in evaluation, for example certain magnetic resonance 
      imaging (MRI) protocols, and also due to ethical considerations. In addition,
      whether disease-modifying treatments are reimbursed in a given country or not
      will influence what sort of patients are likely to get included in clinical trial
      protocols.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Montalban, Xavier
AU  - Montalban X
AD  - Unitat de Neuroimmunologia, Centre d'Esclerosi Multiple de Catalunya (CEM-Cat),
      Hospital Universitari Vall d'Hebron, Barcelona, Spain.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Clinical Trials as Topic/*methods/standards
MH  - Humans
MH  - Immunosuppressive Agents/adverse effects/*therapeutic use
MH  - Multiple Sclerosis/diagnosis/*drug therapy
MH  - Outcome Assessment, Health Care/standards
MH  - Research Design/standards
MH  - Time Factors
EDAT- 2011/12/31 06:00
MHDA- 2014/11/13 06:00
CRDT- 2011/12/31 06:00
PHST- 2011/12/31 06:00 [entrez]
PHST- 2011/12/31 06:00 [pubmed]
PHST- 2014/11/13 06:00 [medline]
AID - S0022-510X(11)70007-7 [pii]
AID - 10.1016/S0022-510X(11)70007-7 [doi]
PST - ppublish
SO  - J Neurol Sci. 2011 Dec;311 Suppl 1:S35-42. doi: 10.1016/S0022-510X(11)70007-7.


PMID- 22206616
OWN - NLM
STAT- MEDLINE
DCOM- 20120703
LR  - 20211021
IS  - 1747-5341 (Electronic)
IS  - 1747-5341 (Linking)
VI  - 6
DP  - 2011 Dec 29
TI  - Donation after cardiocirculatory death: a call for a moratorium pending full
      public disclosure and fully informed consent.
PG  - 17
LID - 10.1186/1747-5341-6-17 [doi]
AB  - Many believe that the ethical problems of donation after cardiocirculatory death 
      (DCD) have been "worked out" and that it is unclear why DCD should be resisted.
      In this paper we will argue that DCD donors may not yet be dead, and therefore
      that organ donation during DCD may violate the dead donor rule. We first present 
      a description of the process of DCD and the standard ethical rationale for the
      practice. We then present our concerns with DCD, including the following:
      irreversibility of absent circulation has not occurred and the many attempts to
      claim it has have all failed; conflicts of interest at all steps in the DCD
      process, including the decision to withdraw life support before DCD, are simply
      unavoidable; potentially harmful premortem interventions to preserve organ
      utility are not justifiable, even with the help of the principle of double
      effect; claims that DCD conforms with the intent of the law and current accepted 
      medical standards are misleading and inaccurate; and consensus statements by
      respected medical groups do not change these arguments due to their low quality
      including being plagued by conflict of interest. Moreover, some arguments in
      favor of DCD, while likely true, are "straw-man arguments," such as the great
      benefit of organ donation. The truth is that honesty and trustworthiness require 
      that we face these problems instead of avoiding them. We believe that DCD is not 
      ethically allowable because it abandons the dead donor rule, has unavoidable
      conflicts of interests, and implements premortem interventions which can hasten
      death. These important points have not been, but need to be fully disclosed to
      the public and incorporated into fully informed consent. These are tall orders,
      and require open public debate. Until this debate occurs, we call for a
      moratorium on the practice of DCD.
FAU - Joffe, Ari R
AU  - Joffe AR
AD  - Department of Pediatrics, University of Alberta, Stollery Children's Hospital,
      Edmonton Clinic Health Academy 11405-87 Avenue, Edmonton, Alberta, T6G 1C9,
      Canada. ari.joffe@albertahealthservices.ca
FAU - Carcillo, Joe
AU  - Carcillo J
FAU - Anton, Natalie
AU  - Anton N
FAU - deCaen, Allan
AU  - deCaen A
FAU - Han, Yong Y
AU  - Han YY
FAU - Bell, Michael J
AU  - Bell MJ
FAU - Maffei, Frank A
AU  - Maffei FA
FAU - Sullivan, John
AU  - Sullivan J
FAU - Thomas, James
AU  - Thomas J
FAU - Garcia-Guerra, Gonzalo
AU  - Garcia-Guerra G
LA  - eng
PT  - Journal Article
DEP - 20111229
PL  - England
TA  - Philos Ethics Humanit Med
JT  - Philosophy, ethics, and humanities in medicine : PEHM
JID - 101258058
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Consensus
MH  - *Death
MH  - *Disclosure
MH  - Female
MH  - Humans
MH  - *Informed Consent
MH  - Male
MH  - Middle Aged
MH  - Tissue and Organ Procurement/*ethics
PMC - PMC3313846
EDAT- 2011/12/31 06:00
MHDA- 2012/07/04 06:00
CRDT- 2011/12/31 06:00
PHST- 2011/07/15 00:00 [received]
PHST- 2011/12/29 00:00 [accepted]
PHST- 2011/12/31 06:00 [entrez]
PHST- 2011/12/31 06:00 [pubmed]
PHST- 2012/07/04 06:00 [medline]
AID - 1747-5341-6-17 [pii]
AID - 10.1186/1747-5341-6-17 [doi]
PST - epublish
SO  - Philos Ethics Humanit Med. 2011 Dec 29;6:17. doi: 10.1186/1747-5341-6-17.


PMID- 22206581
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1756-0500 (Electronic)
IS  - 1756-0500 (Linking)
VI  - 4
DP  - 2011 Dec 29
TI  - 17-Hydroxyprogesterone caproate to prolong pregnancy after preterm rupture of the
      membranes: early termination of a double-blind, randomized clinical trial.
PG  - 568
LID - 10.1186/1756-0500-4-568 [doi]
AB  - BACKGROUND: Progestational agents may reduce the risk of preterm birth in women
      with various risk factors. We sought to test the hypothesis that a weekly dose of
      17-hydroxyprogesterone caproate (17P) given to women with preterm rupture of the 
      membranes (PROM) will prolong pregnancy and thereby reduce neonatal morbidity.
      METHODS: Double-blind, placebo-controlled randomized clinical trial. Women with
      PROM at 23.0 to 31.9 weeks of gestation were randomly assigned to receive a
      weekly intramuscular injection of 17P (250 mg in 1 mL castor oil) or placebo (1
      mL castor oil). The primary outcome was the rate of continuing the pregnancy
      until 34.0 weeks of gestation or until documentation of fetal lung maturity at
      32.0 to 33.9 weeks of gestation. Planned secondary outcomes were duration of
      latency period and rate of composite neonatal morbidity. Enrollment of 111
      participants per group, 222 total, was planned to yield 80% power to detect an
      increase in the primary outcome from 30% with placebo to 50% with 17P. RESULTS:
      Twelve women were enrolled of whom 4 were randomly assigned to receive 17P and 8 
      to receive placebo. The trial was terminated prematurely because of two separate 
      issues related to the supply of 17P. No adverse events attributable to 17P were
      identified. CONCLUSION: Because of premature termination, the trial does not have
      adequate statistical power to evaluate efficacy or safety of 17P in women with
      PROM. Nonetheless, ethical principles dictate that we report the results, which
      may contribute to possible future metaanalyses and systematic reviews. TRIAL
      REGISTRATION: ClinicalTrials.gov: NCT01119963Supported by a research grant from
      the Center for Research, Education, and Quality, Pediatrix Medical Group,
      Sunrise, FL.
FAU - Combs, C Andrew
AU  - Combs CA
AD  - Obstetrix Medical Group, Center for Research, Quality, and Education, San Jose,
      CA, USA. andrewcombs@me.com.
FAU - Garite, Thomas J
AU  - Garite TJ
FAU - Maurel, Kimberly
AU  - Maurel K
FAU - Mallory, Kimberly
AU  - Mallory K
FAU - Edwards, Rodney K
AU  - Edwards RK
FAU - Lu, George
AU  - Lu G
FAU - Porreco, Richard
AU  - Porreco R
FAU - Das, Anita
AU  - Das A
CN  - Obstetrix Collaborative Research Network
LA  - eng
SI  - ClinicalTrials.gov/NCT01119963
PT  - Journal Article
DEP - 20111229
PL  - England
TA  - BMC Res Notes
JT  - BMC research notes
JID - 101462768
PMC - PMC3260323
EDAT- 2011/12/31 06:00
MHDA- 2011/12/31 06:01
CRDT- 2011/12/31 06:00
PHST- 2011/10/12 00:00 [received]
PHST- 2011/12/29 00:00 [accepted]
PHST- 2011/12/31 06:00 [entrez]
PHST- 2011/12/31 06:00 [pubmed]
PHST- 2011/12/31 06:01 [medline]
AID - 1756-0500-4-568 [pii]
AID - 10.1186/1756-0500-4-568 [doi]
PST - epublish
SO  - BMC Res Notes. 2011 Dec 29;4:568. doi: 10.1186/1756-0500-4-568.


PMID- 22206208
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20111230
IS  - 1293-8505 (Print)
IS  - 1293-8505 (Linking)
IP  - 175
DP  - 2011 Nov
TI  - [The components of an ethical approach].
PG  - 30-2
AB  - A new bi-monthly feature in La revue de l'Infirmiere on the theme of ethics and
      the resulting dilemmas, so often encountered in nursing contexts. Far from being 
      prescriptive and giving turnkey solutions, we will open the debate on ethical
      questioning. One which envisages the scope of possibilities and searches for the 
      best decision for each particular situation. This first article offers elements
      of methodology.
FAU - Svandra, Philippe
AU  - Svandra P
AD  - Universite Paris-Est Marne-la-Vallee. p.svandra@ch-sainte-anne.fr
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Reperes methodologiques a la recherche de la juste voie.
PL  - France
TA  - Rev Infirm
JT  - Revue de l'infirmiere
JID - 1267175
MH  - *Ethics, Nursing
MH  - Humans
MH  - Nurse-Patient Relations
EDAT- 2011/12/31 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/12/31 06:00
PHST- 2011/12/31 06:00 [entrez]
PHST- 2011/12/31 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
PST - ppublish
SO  - Rev Infirm. 2011 Nov;(175):30-2.


PMID- 22206156
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20161125
IS  - 1472-0795 (Print)
IS  - 1472-0795 (Linking)
VI  - 23
IP  - 9
DP  - 2011 Nov
TI  - A comparison of elderly care nursing in the UK and Japan.
PG  - 31-5
AB  - AIM: The aim of this study was to gain insight into registered nurses'
      experiences of caring for older people in the UK and Japan. METHOD: Critical
      incident technique was used because of its ability to capture actual incidents
      from practice. Written, anonymous self-report data were collected during 2010.
      Participants were asked to recall two critical incidents where they had felt
      either rewarded or challenged at work. Data were analysed using thematic
      analysis. FINDINGS: Analysis revealed striking similarities in the experiences of
      nurses from both countries. Four main themes emerged: the challenges of a complex
      work environment; the challenges of resolving ethical conflicts; the rewards of
      establishing meaningful relationships; and the rewards of achieving excellence in
      individual patient care. CONCLUSION: The study provides new evidence from two
      different countries that although there are some challenges, nurses reap many
      rewards from working with older people.
FAU - Bradbury-Jones, Caroline
AU  - Bradbury-Jones C
AD  - University of Dundee. c.bradburyjones@dundee.ac.uk
FAU - Irvine, Fiona
AU  - Irvine F
FAU - Jones, Colin
AU  - Jones C
FAU - Kakehashi, Chikako
AU  - Kakehashi C
FAU - Ogi, Ayako
AU  - Ogi A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nurs Older People
JT  - Nursing older people
JID - 101084156
MH  - Aged
MH  - Attitude of Health Personnel
MH  - Cross-Cultural Comparison
MH  - *Geriatric Nursing
MH  - Humans
MH  - Japan
MH  - Nurse-Patient Relations
MH  - United Kingdom
EDAT- 2011/12/31 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/12/31 06:00
PHST- 2011/12/31 06:00 [entrez]
PHST- 2011/12/31 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - 10.7748/nop2011.11.23.9.31.c8781 [doi]
PST - ppublish
SO  - Nurs Older People. 2011 Nov;23(9):31-5. doi: 10.7748/nop2011.11.23.9.31.c8781.


PMID- 22205918
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1861-8863 (Electronic)
IS  - 1861-8863 (Linking)
VI  - 7
DP  - 2011
TI  - Percutaneous coronary intervention with optimal medical therapy vs. optimal
      medical therapy alone for patients with stable angina pectoris.
PG  - Doc07
LID - 10.3205/hta000098 [doi]
AB  - SCIENTIFIC BACKGROUND: Stable Angina Pectoris (AP) is a main syndrome of chronic 
      coronary artery disease (CAD), a disease with enormous epidemiological and health
      economic relevance. Medical therapy and percutaneous coronary interventions (PCI)
      are the most important methods used in the treatment of chronic CAD. RESEARCH
      QUESTIONS: The evaluation addresses questions on medical efficacy, incremental
      cost-effectiveness as well as ethic, social and legal aspects in the use of PCI
      in CAD patients in comparison to optimal medical therapy alone. METHODS: A
      systematic literature search was conducted in June 2010 in the electronic
      databases (MEDLINE, EMBASE etc.) and was completed by a hand search. The medical 
      analysis was initially based on systematic reviews of randomized controlled
      trials (RCT) and was followed by the evaluation of RCT with use of current
      optimal medical therapy. The results of the RCT were combined using
      meta-analysis. The strength and the applicability of the determined evidence were
      appraised. The health economic analysis was initially focused on the published
      studies. Additionally, a health economic modelling was performed with clinical
      assumptions derived from the conducted meta-analysis and economic assumptions
      derived from the German Diagnosis Related Groups 2011. RESULTS: Seven systematic 
      reviews (applicability of the evidence low) and three RCT with use of optimal
      medical therapy (applicability of the evidence for the endpoints AP and
      revascularisations moderate, for further endpoints high) were included in the
      medical analysis. The results from RCT are used as a base of the evaluation. The 
      routine use of the PCI reduces the proportion of patients with AP attacks in the 
      follow-up after one and after three years in comparison with optimal medical
      therapy alone (evidence strength moderate); however, this effect was not
      demonstrated in the follow-up after five years (evidence strength low). The
      difference in effect in the follow-up after four to five years was not found for 
      the further investigated clinical endpoints: death, cardiac death, myocardial
      infarction and stroke (evidence strength high) as well as for severe heart
      failure (evidence strength moderate). Two studies were included in the health
      economic analysis. The costs estimations from these studies are not directly
      transferable to the corresponding costs in Germany. The average difference in the
      total costs for PCI in comparison with optimal medical therapy alone, which was
      calculated in the modelling, was found to be 4,217 Euro per patient. The
      incremental cost-effectiveness ratio per life-year of a patient with avoided AP
      attacks was estimated to be 24,805 Euro (evidence strength moderate). No
      publication was identified concerning ethical, social or legal aspects.
      DISCUSSION: Important methodical problems of the studies are a lack of blinding
      of the patients and incomplete data for several endpoints in the follow-up. The
      determined incremental cost-effectiveness ratio per life-year of a patient with
      avoided AP attacks was appraised not to be cost-effective. CONCLUSIONS: From a
      medical point of view the routine use of PCI in addition to the optimal medicinal
      therapy in patients with stable AP can be recommended for the reduction of the
      proportion of patients with AP attacks after one year and after three years
      (recommendation degree weak). Otherwise, PCI is to be performed in patients with 
      refractory or progressing AP despite of optimal medical therapy use; in this case
      PCI is expected to be applied in 27% to 30% of patients in five years. From the
      health economic view the routine use of PCI in addition to an optimal medical
      therapy in patients with stable AP cannot be recommended. No special
      considerations can be made concerning special ethical, social or legal aspects in
      the routine use of PCI in addition to optimal medical therapy in patients with
      stable AP.
FAU - Gorenoi, Vitali
AU  - Gorenoi V
AD  - Institute for Epidemiology, Social Medicine and Health Systems Research,
      Hannover, Germany.
FAU - Schonermark, Matthias P
AU  - Schonermark MP
FAU - Hagen, Anja
AU  - Hagen A
LA  - eng
PT  - Journal Article
DEP - 20111110
PL  - Germany
TA  - GMS Health Technol Assess
JT  - GMS health technology assessment
JID - 101276045
PMC - PMC3244729
OTO - NOTNLM
OT  - CAD
OT  - Germany
OT  - PCI
OT  - RCT
OT  - acute coronary syndrom/therapy
OT  - angina pectoris/*
OT  - angioplasty
OT  - balloon-dilation/therapy
OT  - blood flow
OT  - blood supply
OT  - cardiac muscle
OT  - circulatory disorder
OT  - coronary heart disease
OT  - cost-benefit analysis
OT  - drug therapy/*
OT  - drug therapy/*economics
OT  - drug-eluting stents
OT  - drug-eluting stents/adverse effects
OT  - drug-eluting stents/economics
OT  - drug-eluting stents/utilization
OT  - health economic analysis
OT  - heart diseases/*
OT  - humans
OT  - ischemia
OT  - medicamental therapy
OT  - meta analysis
OT  - meta analysis as topic
OT  - myocardial insufficiency
OT  - myocardial ischemia
OT  - myocardium
OT  - percutaneous coronary intervention
OT  - perfusion
OT  - prevention
OT  - primary prevention
OT  - prophylaxis
OT  - randomized controlled trial
OT  - randomized controlled trial as topic
OT  - review literature
OT  - stable angina pectoris
OT  - stenting
OT  - systematic review
OT  - therapeutics
OT  - treatment
EDAT- 2011/12/30 06:00
MHDA- 2011/12/30 06:01
CRDT- 2011/12/30 06:00
PHST- 2011/12/30 06:00 [entrez]
PHST- 2011/12/30 06:00 [pubmed]
PHST- 2011/12/30 06:01 [medline]
AID - 10.3205/hta000098 [doi]
AID - hta000098 [pii]
PST - ppublish
SO  - GMS Health Technol Assess. 2011;7:Doc07. doi: 10.3205/hta000098. Epub 2011 Nov
      10.


PMID- 22205694
OWN - NLM
STAT- MEDLINE
DCOM- 20120315
LR  - 20190722
IS  - 1530-8561 (Electronic)
IS  - 0009-9147 (Linking)
VI  - 58
IP  - 2
DP  - 2012 Feb
TI  - Fetal laboratory medicine: on the frontier of maternal-fetal medicine.
PG  - 337-52
LID - 10.1373/clinchem.2011.166991 [doi]
AB  - BACKGROUND: Emerging antenatal interventions and care delivery to the fetus
      require diagnostic support, including laboratory technologies, appropriate
      methodologies, establishment of special algorithms, and interpretative guidelines
      for clinical decision-making. CONTENT: Fetal diagnostic and therapeutic
      interventions vary in invasiveness and are associated with a spectrum of risks
      and benefits. Fetal laboratory assessments are well served by miniaturized
      diagnostic methods for blood analysis. Expedited turnaround times are mandatory
      to support invasive interventions such as cordocentesis and intrauterine
      transfusions. Health-associated reference intervals are required for fetal test
      interpretation. Fetal blood sampling by cordocentesis carries substantial risk
      and is therefore performed only when fetal health is impaired, or at risk. When
      the suspected pathology is not confirmed, however, normative fetal data can be
      collected. Strategies for assurance of sample integrity from cordocenteses and
      confirmation of fetal origin are described. After birth, definitive assessment of
      prenatal environmental and/or drug exposures to the fetus can be retrospectively 
      assessed by analysis of meconium, hair, and other alternative matrices. A rapidly
      advancing technology for fetal assessment is the use of fetal laboratory
      diagnostic techniques that use cell-free fetal DNA collected from maternal
      plasma, and genetic analysis based on molecular counting techniques. SUMMARY:
      Developmental changes in fetal biochemical and hematologic parameters in health
      and disease are continually delineated by analysis of our collective
      outcome-based experience. Noninvasive technologies for fetal evaluation are
      realizing the promise of lower risk yet robust diagnostics; examples include
      sampling and analysis of free fetal DNA from maternal blood, and analysis of
      fetal products accessible at maternal sites. Application of diagnostic
      technologies for nonmedical purposes (e.g., sex selection) underscores the
      importance of ethical guidelines for new technology implementation.
FAU - Geaghan, Sharon M
AU  - Geaghan SM
AD  - Department of Pathology, Stanford University School of Medicine, Palo Alto,
      California, USA. sgeaghan@stanford.edu
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111228
PL  - England
TA  - Clin Chem
JT  - Clinical chemistry
JID - 9421549
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Aneuploidy
MH  - Clinical Laboratory Techniques/*methods
MH  - Cordocentesis
MH  - DNA/blood
MH  - Female
MH  - Fetal Diseases/*diagnosis/*therapy
MH  - Fetoscopy
MH  - Genetic Testing
MH  - Humans
MH  - Maternal Exposure
MH  - Maternal-Fetal Exchange
MH  - Practice Guidelines as Topic
MH  - Pregnancy
MH  - Prenatal Diagnosis/*methods
MH  - Reference Values
EDAT- 2011/12/30 06:00
MHDA- 2012/03/16 06:00
CRDT- 2011/12/30 06:00
PHST- 2011/12/30 06:00 [entrez]
PHST- 2011/12/30 06:00 [pubmed]
PHST- 2012/03/16 06:00 [medline]
AID - clinchem.2011.166991 [pii]
AID - 10.1373/clinchem.2011.166991 [doi]
PST - ppublish
SO  - Clin Chem. 2012 Feb;58(2):337-52. doi: 10.1373/clinchem.2011.166991. Epub 2011
      Dec 28.


PMID- 22205578
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1868-6001 (Electronic)
IS  - 1868-310X (Linking)
VI  - 3
IP  - 3
DP  - 2012 Jul
TI  - Preconception care and genetic risk: ethical issues.
PG  - 221-8
LID - 10.1007/s12687-011-0074-9 [doi]
AB  - Preconception care to address genetic risks in reproduction may be offered either
      individually to couples with a known or suspected increased risk of having a
      child with a genetic disorder, or systematically to couples or individuals of
      reproductive age. The identification of couples at risk of transmitting a
      (serious) genetic disorder allows those couples to refrain from having children
      or to adapt their reproductive plans (using prenatal or preimplantation
      diagnosis, donor gametes, or adoption). Ethical issues concern the possible
      objectives of providing these options through preconception genetic counseling or
      screening, objections to abortion and embryo-selection, concerns about eugenics
      and medicalization, and issues arising in the professional-client relationship
      and/or in the light of the normative framework for population screening. Although
      enhancing reproductive autonomy rather than prevention should be regarded as the 
      primary aim of preconception care for genetic risks, directive counseling may
      well be acceptable in exceptional cases, and prevention in the sense of avoiding 
      serious suffering may be an appropriate objective of specific community-based
      preconception screening programmes. The seemingly unavoidable prospect of
      comprehensive preconception screening raises further ethical issues.
FAU - De Wert, Guido M W R
AU  - De Wert GM
AD  - Department of Health, Ethics & Society, Faculty of Health, Medicine & Life
      Sciences, Research Schools CAPHRI and GROW, Maastricht University, Maastricht,
      The Netherlands.
FAU - Dondorp, Wybo J
AU  - Dondorp WJ
FAU - Knoppers, Bartha M
AU  - Knoppers BM
LA  - eng
PT  - Journal Article
DEP - 20111229
PL  - Germany
TA  - J Community Genet
JT  - Journal of community genetics
JID - 101551501
PMC - PMC3419287
EDAT- 2011/12/30 06:00
MHDA- 2011/12/30 06:01
CRDT- 2011/12/30 06:00
PHST- 2011/07/29 00:00 [received]
PHST- 2011/12/07 00:00 [accepted]
PHST- 2011/12/30 06:00 [entrez]
PHST- 2011/12/30 06:00 [pubmed]
PHST- 2011/12/30 06:01 [medline]
AID - 10.1007/s12687-011-0074-9 [doi]
PST - ppublish
SO  - J Community Genet. 2012 Jul;3(3):221-8. doi: 10.1007/s12687-011-0074-9. Epub 2011
      Dec 29.


PMID- 22205018
OWN - NLM
STAT- MEDLINE
DCOM- 20130318
LR  - 20121015
IS  - 1873-7862 (Electronic)
IS  - 0924-977X (Linking)
VI  - 22
IP  - 11
DP  - 2012 Nov
TI  - Head to head comparisons as an alternative to placebo-controlled trials.
PG  - 800-3
LID - 10.1016/j.euroneuro.2011.11.011 [doi]
LID - S0924-977X(11)00310-5 [pii]
AB  - Head to head trials have been proposed as an alternative to the ethical and
      methodological concerns related to placebo-controlled trials. While those studies
      may be particularly informative from the clinical and cost-effectiveness
      point-of-view, avoiding placebo poses several regulatory concerns: for
      superiority designs, the choice of the trial population, outcomes, dose and
      escalation of the comparator, as well as the comparator itself may be an issue;
      for non-inferiority studies, issues related to uncertain assay sensitivity and
      exposure of large samples to potentially ineffective or unsafe drugs make them
      inappropriate, in the absence of a previous positive superiority trial, for
      regulatory purposes. The inclusion of active comparators in regulatory trials
      should not be seen as an alternative, but as a useful complement to the
      information that can be obtained from placebo-controlled studies.
CI  - Copyright (c) 2011 Elsevier B.V. and ECNP. All rights reserved.
FAU - Vieta, Eduara
AU  - Vieta E
AD  - Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS,
      CIBERSAM, Villarroel 170, Barcelona 08036, Catalonia, Spain. evieta@clinic.ub.es
FAU - Cruz, Nuria
AU  - Cruz N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111226
PL  - Netherlands
TA  - Eur Neuropsychopharmacol
JT  - European neuropsychopharmacology : the journal of the European College of
      Neuropsychopharmacology
JID - 9111390
RN  - 0 (Placebos)
RN  - 0 (Psychotropic Drugs)
SB  - IM
MH  - Controlled Clinical Trials as Topic/economics/ethics/*methods
MH  - Humans
MH  - Mental Disorders/drug therapy/metabolism/psychology
MH  - Placebos
MH  - Psychopharmacology/economics/ethics/*methods
MH  - Psychotropic Drugs/pharmacokinetics/therapeutic use
MH  - Therapeutic Equivalency
EDAT- 2011/12/30 06:00
MHDA- 2013/03/19 06:00
CRDT- 2011/12/30 06:00
PHST- 2011/08/12 00:00 [received]
PHST- 2011/11/03 00:00 [revised]
PHST- 2011/11/14 00:00 [accepted]
PHST- 2011/12/30 06:00 [entrez]
PHST- 2011/12/30 06:00 [pubmed]
PHST- 2013/03/19 06:00 [medline]
AID - S0924-977X(11)00310-5 [pii]
AID - 10.1016/j.euroneuro.2011.11.011 [doi]
PST - ppublish
SO  - Eur Neuropsychopharmacol. 2012 Nov;22(11):800-3. doi:
      10.1016/j.euroneuro.2011.11.011. Epub 2011 Dec 26.


PMID- 22204676
OWN - NLM
STAT- MEDLINE
DCOM- 20120420
LR  - 20111229
IS  - 1471-5457 (Electronic)
IS  - 0730-9384 (Linking)
VI  - 30
IP  - 1
DP  - 2011 Spring
TI  - Darwin and the Declaration.
PG  - 2-16
LID - 10.2990/30_1_2 [doi]
AB  - Does the prima facie contradiction between the Declaration of Independence's
      description of the separate and unique "creation" of human beings and Darwin's
      evolutionary account indicate a broader contradiction between theories of human
      rights and Darwinian evolution? While similar troubling questions have been
      raised and answered in the affirmative since Darwin's time, this article renews, 
      updates and significantly fortifies such answers with original arguments. If a
      "distilled" formulation of the Declaration's central claims, shorn of
      complicating entanglements with both theology and comprehensive philosophical
      doctrines, may still be in contradiction with Darwinian evolutionary theory, this
      should be cause for substantial concern on the part of all normative political
      theorists, from Straussians to Rawlsians. Despite the notable recent efforts of a
      few political theorists, evolutionary ethicists and sociobiologists to establish 
      the compatibility of Darwinian evolutionary theory with moral norms such as the
      idea of natural or human rights, I argue that significant obstacles remain.
FAU - Seagrave, S Adam
AU  - Seagrave SA
AD  - Department of Political Science, University of Notre Dame, 217 O'Shaughnessy
      Hall, Notre Dame, IN 46556 , USA. sseagrav@nd.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Politics Life Sci
JT  - Politics and the life sciences : the journal of the Association for Politics and 
      the Life Sciences
JID - 8800535
SB  - IM
MH  - American Revolution
MH  - *Biological Evolution
MH  - Ethical Theory
MH  - *Human Rights
MH  - Humans
MH  - Philosophy
MH  - *Politics
MH  - United States
MH  - Writing
EDAT- 2011/12/30 06:00
MHDA- 2012/04/21 06:00
CRDT- 2011/12/30 06:00
PHST- 2011/12/30 06:00 [entrez]
PHST- 2011/12/30 06:00 [pubmed]
PHST- 2012/04/21 06:00 [medline]
AID - 10.2990/30_1_2 [doi]
PST - ppublish
SO  - Politics Life Sci. 2011 Spring;30(1):2-16. doi: 10.2990/30_1_2.


PMID- 22204557
OWN - NLM
STAT- MEDLINE
DCOM- 20120328
LR  - 20220409
IS  - 1471-2334 (Electronic)
IS  - 1471-2334 (Linking)
VI  - 11
DP  - 2011 Dec 28
TI  - The definition of HIV-associated neurocognitive disorders: are we overestimating 
      the real prevalence?
PG  - 356
LID - 10.1186/1471-2334-11-356 [doi]
AB  - BACKGROUND: A substantial prevalence of mild neurocognitive disorders has been
      reported in HIV, also in patients treated with combination antiretroviral therapy
      (cART). This includes a new disorder that has been termed asymptomatic
      neurocognitive impairment (ANI). DISCUSSION: ANI is identified by performance on 
      formal neuropsychological testing that is at least 1 SD below the mean of
      normative scores in at least two cognitive domains out of at least five examined 
      in patients without associated symptoms or evident functional impairment in daily
      living. While two tests are recommended to assess each domain, only one is
      required to fulfill this diagnostic criterion. Unfortunately, this definition
      necessitates that about 20% of the cognitively normal HIV-infected population is 
      classified as suffering ANI. This liberal definition raises important ethical
      concerns and has as well diagnostic and therapeutic implications. Since neither
      its biological substrate, prognostic significance nor therapeutic implications
      are clearly established, we recommend that this diagnosis be modified or applied 
      cautiously. SUMMARY: The diagnoses of less severe forms of neurocognitive
      disorders in HIV relies on the outcomes of neuropsychological testing, and a high
      proportion of HIV-infected patients with effective cART may be classified as
      neurocognitively abnormal using the current criteria. The definition of ANI is
      not stringent, and results in approximately 20% of the population being
      classified as abnormal. To us this seems an unacceptable false-positive rate.
FAU - Gisslen, Magnus
AU  - Gisslen M
AD  - Department of Infectious Diseases, Sahlgrenska University Hospital, University of
      Gothenburg, Sweden. magnus.gisslen@gu.se
FAU - Price, Richard W
AU  - Price RW
FAU - Nilsson, Staffan
AU  - Nilsson S
LA  - eng
PT  - Journal Article
DEP - 20111228
PL  - England
TA  - BMC Infect Dis
JT  - BMC infectious diseases
JID - 100968551
SB  - IM
MH  - AIDS Dementia Complex/*diagnosis/*epidemiology/pathology
MH  - Asymptomatic Diseases/*epidemiology
MH  - HIV Infections/*complications
MH  - Humans
MH  - Prevalence
PMC - PMC3260107
EDAT- 2011/12/30 06:00
MHDA- 2012/03/29 06:00
CRDT- 2011/12/30 06:00
PHST- 2011/08/24 00:00 [received]
PHST- 2011/12/28 00:00 [accepted]
PHST- 2011/12/30 06:00 [entrez]
PHST- 2011/12/30 06:00 [pubmed]
PHST- 2012/03/29 06:00 [medline]
AID - 1471-2334-11-356 [pii]
AID - 10.1186/1471-2334-11-356 [doi]
PST - epublish
SO  - BMC Infect Dis. 2011 Dec 28;11:356. doi: 10.1186/1471-2334-11-356.


PMID- 22204259
OWN - NLM
STAT- MEDLINE
DCOM- 20120306
LR  - 20220316
IS  - 0030-9982 (Print)
IS  - 0030-9982 (Linking)
VI  - 61
IP  - 7
DP  - 2011 Jul
TI  - Pakistani medical students' specialty preference and the influencing factors.
PG  - 713-8
AB  - OBJECTIVE: To elucidate the specialty preferences of Pakistani medical students
      and the factors which influence medical students to make the decision regarding
      which specialty to pursue. METHODS: Both basic sciences and clinical students
      from four medical colleges of Pakistan, i.e., Dow Medical College, Sindh Medical 
      College, Liaquat National Medical College and Muhammad Medical College, were
      included in the cross-sectional survey during the period of July 2008 to Jan'
      2009. After ethical acceptance, data was collected using convenient sampling
      technique. The questionnaire covered the following demographic details: 13 common
      specialties and 15 influencing factors. RESULTS: Questionnaires included in the
      analysis were 771. Most students gave preference to surgery and its associated
      sub-specialties (50.3%) followed by internal medicine (26.8%), paediatrics
      (23.2%), dermatology (16.7%), gynaecology and obstetrics (16.7%), psychiatry
      (13.1%), radiology (10.8%), ENT (8.8%), anaesthesiology (8.7%), administrative
      medicine (8.6%), orthopaedics (8.2%), ophthalmology (7.5%), and laboratory
      medicine (6.1%). The highly considered factors (regarding specialties) chosen by 
      70% of the medical students were: applicable to respective personalities of the
      individuals, prestige and respect, international opportunities, and time
      commitment. Surgical-skills, job availability, financial rating, academic
      performance, and a role model were moderately influencing factors. Hospital
      environment, parents, general practice, peer-pressure and personal health were
      the least influential. CONCLUSION: This trend suggests competition in surgery and
      its sub-specialties along with internal medicine, paediatrics, dermatology,
      gynaecology and obstetrics. Specialty suited to personality, time commitment,
      prestige/respect and international opportunity, influenced more than 70% of the
      students.
FAU - Rehman, Anis
AU  - Rehman A
AD  - Dow Medical College, Karachi.
FAU - Rehman, Tariq
AU  - Rehman T
FAU - Shaikh, Muhammad Ateeb
AU  - Shaikh MA
FAU - Yasmin, Haleema
AU  - Yasmin H
FAU - Asif, Ammara
AU  - Asif A
FAU - Kafil, Hina
AU  - Kafil H
LA  - eng
PT  - Journal Article
PL  - Pakistan
TA  - J Pak Med Assoc
JT  - JPMA. The Journal of the Pakistan Medical Association
JID - 7501162
SB  - IM
MH  - Adult
MH  - *Career Choice
MH  - Cross-Sectional Studies
MH  - Decision Making
MH  - Female
MH  - Humans
MH  - Male
MH  - Pakistan
MH  - *Specialization
MH  - Students, Medical/*statistics & numerical data
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2011/12/30 06:00
MHDA- 2012/03/07 06:00
CRDT- 2011/12/30 06:00
PHST- 2011/12/30 06:00 [entrez]
PHST- 2011/12/30 06:00 [pubmed]
PHST- 2012/03/07 06:00 [medline]
AID - 2881 [pii]
PST - ppublish
SO  - J Pak Med Assoc. 2011 Jul;61(7):713-8.


PMID- 22204182
OWN - NLM
STAT- MEDLINE
DCOM- 20120228
LR  - 20151119
IS  - 0030-9982 (Print)
IS  - 0030-9982 (Linking)
VI  - 61
IP  - 5
DP  - 2011 May
TI  - Parents' opinion of quality of life (QOL) in Pakistani thalassaemic children.
PG  - 470-3
AB  - OBJECTIVE: To find out the physical, social, psychological life aspects and
      overall quality of life among thalassaemic children in Pakistan. METHODS: This
      cross-sectional study was done in ten Thalassaemia treatment centres in three
      major cities of Pakistan during the year 2007-08. The study population comprised 
      of 221 thalassaemic children ranging from 4 to 12 years age brought for blood
      transfusion by their parents. All ethical considerations were taken into account 
      during the study. Questions related to physical, social and psychological aspects
      that assess quality of life (QOL) of children with thalassaemia were asked and
      were further analyzed using SPSS version 12.0. RESULTS: Out of total 221
      thalassaemic patients surveyed, the majority (61%) were boys with a mean age of
      8.5 +/- 2.26 years for both sexes. An overwhelming majority of parents (86%) felt
      that the disease did not affect the child's family or social relationships.
      However, poorer quality of life (QOL) was found against psychological aspects (p 
      < 0.05) and overall parent satisfaction for child's health (p < 0.001). Adverse
      impact of thalassaemia was also found for pain (73%), sleep (50%), eating habits 
      (49%), leisure activities (54%) and task concentration (51%) among the
      participants. CONCLUSION: There was a substantial amount of concern raised by the
      parents for various aspects of QoL in their affected children. Hence, it is
      crucial to provide proper health education to parents for better understanding of
      the disease and rehabilitation of their thalassaemic children.
FAU - Ammad, Syed Ali
AU  - Ammad SA
AD  - Hamdard College of Medicine & Dentistry, Karachi.
FAU - Mubeen, Syed Muhammad
AU  - Mubeen SM
FAU - Shah, Syed Faraz Ul Hassan
AU  - Shah SF
FAU - Mansoor, Salman
AU  - Mansoor S
LA  - eng
PT  - Journal Article
PL  - Pakistan
TA  - J Pak Med Assoc
JT  - JPMA. The Journal of the Pakistan Medical Association
JID - 7501162
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Family
MH  - Female
MH  - Humans
MH  - Male
MH  - Pakistan
MH  - Parents
MH  - *Quality of Life
MH  - Severity of Illness Index
MH  - Surveys and Questionnaires
MH  - Thalassemia/diagnosis/*physiopathology/*psychology
EDAT- 2011/12/30 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/12/30 06:00
PHST- 2011/12/30 06:00 [entrez]
PHST- 2011/12/30 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - 2780 [pii]
PST - ppublish
SO  - J Pak Med Assoc. 2011 May;61(5):470-3.


PMID- 22204086
OWN - NLM
STAT- MEDLINE
DCOM- 20120117
LR  - 20111229
IS  - 0952-6862 (Print)
IS  - 0952-6862 (Linking)
VI  - 24
IP  - 7
DP  - 2011
TI  - Influence of organizational culture on quality healthcare delivery.
PG  - 523-39
AB  - PURPOSE: The purpose of this paper is to identify if aspects of organizational
      culture may indicate a new terrain in the cultural influences-quality healthcare 
      relationship. This research stems from the author's belief that viewing the role 
      of head of department or directorate as pivotal to health care management is
      critical to health care planning and quality healthcare delivery.
      DESIGN/METHODOLOGY/APPROACH: Interviews were undertaken among 50 professional
      clinician and non-clinician managers working in the role of head of department,
      in acute care hospitals in Ireland. The sample was drawn from the total
      population of 850 managers, utilized in a previous survey study. FINDINGS:
      Organizational culture is more complex than was previously thought. Several
      cultural influences such as excellence in care delivery, ethical values,
      involvement, professionalism, value-for-money, cost of care, commitment to
      quality and strategic thinking were found to be key cultural determinants in
      quality care delivery. RESEARCH LIMITATIONS/IMPLICATIONS: Health care managers
      perceive that in order to deliver quality focused care they need to act in a
      professional, committed manner and to place excellence at the forefront of care
      delivery, whilst at the same time being capable of managing the tensions that
      exist between cost effectiveness and quality of care. These tensions require
      further research in order to determine if quality of care is affected in a
      negative manner by those tensions. ORIGINALITY/VALUE: Originality relates to the 
      new cultural terrain presented in this paper that recognizes the potential of
      health service managers to influence the organizations' culture and through this 
      influence to take a greater part in ensuring that quality health care is
      delivered to their patients. It also seems to be important that value-for-money
      is viewed as an ethical means of delivering healthcare, and not as a conflict
      between quality and cost.
FAU - Carney, Marie
AU  - Carney M
AD  - School of Nursing, Royal College of Surgeons in Ireland, Dublin, Ireland.
      mariecarney@rcsi.ie
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Health Care Qual Assur
JT  - International journal of health care quality assurance
JID - 8916799
MH  - Cost Control
MH  - Health Services Research
MH  - *Hospital Administration
MH  - Humans
MH  - *Organizational Culture
MH  - Quality Assurance, Health Care/organization & administration
MH  - Quality of Health Care/*organization & administration
EDAT- 2011/12/30 06:00
MHDA- 2012/01/18 06:00
CRDT- 2011/12/30 06:00
PHST- 2011/12/30 06:00 [entrez]
PHST- 2011/12/30 06:00 [pubmed]
PHST- 2012/01/18 06:00 [medline]
AID - 10.1108/09526861111160562 [doi]
PST - ppublish
SO  - Int J Health Care Qual Assur. 2011;24(7):523-39. doi: 10.1108/09526861111160562.


PMID- 22168546
OWN - NLM
STAT- MEDLINE
DCOM- 20120525
LR  - 20211021
IS  - 1471-2458 (Electronic)
IS  - 1471-2458 (Linking)
VI  - 11 Suppl 5
DP  - 2011 Nov 25
TI  - Looking back in time: conducting a cohort study of the long-term effects of
      treatment of adolescent tall girls with synthetic hormones.
PG  - S7
LID - 10.1186/1471-2458-11-S5-S7 [doi]
AB  - OBJECTIVE: Public health research is an endeavour that often involves multiple
      relationships, far-reaching collaborations, divergent expectations and various
      outcomes. Using the Tall Girls Study as a case study, this paper will present and
      discuss a number of methodological, ethical and legal challenges that have
      implications for other public health research. APPROACH: The Tall Girls Study was
      the first study to examine the long-term health and psychosocial effects of
      oestrogen treatment for tall stature. RESULTS: In undertaking this study the
      research team overcame many hurdles: in maintaining collaboration with treating
      clinicians and with the women they had treated as girls - groups with opposing
      points of view and different expectations; using private practice medical records
      to trace women who had been patients up to forty years earlier; and exploring
      potential legal issues arising from the collection of data related to treatment. 
      CONCLUSION: While faced with complex challenges, the Tall Girls Study
      demonstrated that forward planning, ongoing dialogue between all stakeholders,
      transparency of processes, and the strict adherence to group-developed protocols 
      were keys to maintaining rigour while undertaking pragmatic research.
      IMPLICATIONS: Public health research often occurs within political and social
      contexts that need to be considered in the planning and conduct of studies. The
      quality and acceptability of research findings is enhanced when stakeholders are 
      engaged in all aspects of the research process.
FAU - Bruinsma, Fiona J
AU  - Bruinsma FJ
AD  - Mother and Child Health Research, La Trobe University, 215 Franklin St,
      Melbourne, Victoria 3000, Australia. f.bruinsma@latrobe.edu.edu
FAU - Rayner, Jo-Anne
AU  - Rayner JA
FAU - Venn, Alison J
AU  - Venn AJ
FAU - Pyett, Priscilla
AU  - Pyett P
FAU - Werther, George
AU  - Werther G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111125
PL  - England
TA  - BMC Public Health
JT  - BMC public health
JID - 100968562
RN  - 0 (Estrogens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Australia
MH  - *Body Height
MH  - Cohort Studies
MH  - Cooperative Behavior
MH  - Data Collection/*methods
MH  - Depression/diagnosis
MH  - *Estrogens/adverse effects/therapeutic use
MH  - Female
MH  - Follow-Up Studies
MH  - Growth Disorders/*drug therapy/psychology
MH  - Health Services Research
MH  - Humans
MH  - Information Storage and Retrieval
MH  - Interviews as Topic
MH  - Medical Records
MH  - Outcome and Process Assessment, Health Care/*methods
MH  - Patient Selection
MH  - Research Personnel
MH  - Retrospective Studies
MH  - Surveys and Questionnaires
MH  - Women's Health/statistics & numerical data
PMC - PMC3247030
EDAT- 2011/12/30 06:00
MHDA- 2012/05/26 06:00
CRDT- 2011/12/16 06:00
PHST- 2011/12/16 06:00 [entrez]
PHST- 2011/12/30 06:00 [pubmed]
PHST- 2012/05/26 06:00 [medline]
AID - 1471-2458-11-S5-S7 [pii]
AID - 10.1186/1471-2458-11-S5-S7 [doi]
PST - epublish
SO  - BMC Public Health. 2011 Nov 25;11 Suppl 5:S7. doi: 10.1186/1471-2458-11-S5-S7.


PMID- 22168397
OWN - NLM
STAT- MEDLINE
DCOM- 20120525
LR  - 20211021
IS  - 1471-2458 (Electronic)
IS  - 1471-2458 (Linking)
VI  - 11 Suppl 5
DP  - 2011 Nov 25
TI  - Ethical complexities of screening for depression and intimate partner violence
      (IPV) in intervention studies.
PG  - S3
LID - 10.1186/1471-2458-11-S5-S3 [doi]
AB  - BACKGROUND: Intervention studies for depression and intimate partner violence
      (IPV) commonly incorporate screening to identify eligible participants. The
      challenge is that current ethical evaluation is largely informed by the four
      principle approach applying principles of beneficence, non-maleficence, and
      respect for justice and autonomy. We examine three intervention studies for IPV, 
      postnatal depression (PND) and depression that used screening from the
      perspective of principlism, followed by the perspective of a narrative and
      relational approach. We suggest that a narrative and relational approach to
      ethics brings to light concerns that principlism can overlook. DISCUSSION: The
      justification most commonly used to incorporate screening is that the potential
      benefits of identifying intervention efficacy balance the risk of individual
      harm. However, considerable risks do exist. The discovery of new information may 
      result in further depression or worries, people might feel burdened, open to
      further risk, unsure of whether to disclose information to family members and
      disappointed if they are allocated to a control group. This raises questions
      about study design and whether the principle of equipoise remains an adequate
      justification in studies with vulnerable groups. In addition, autonomy is said to
      be respected because participants give informed consent to participate. However, 
      the context of where recruitment is undertaken has been shown to influence how
      people make decisions. SUMMARY: The four principles have been subjected to
      criticisms in recent years but they remain prominent in public health and medical
      research. We provide a set of simple, interrogative questions that are narrative 
      and relationally driven which may assist to further evaluate the potential
      impacts of using screening to identify eligible research participants in
      intervention studies. A narrative and relational based approach requires seeing
      people as situated within their social and cultural contexts, and as existing
      within relationships that are likely to be affected by the results of screening
      information.
FAU - Palmer, Victoria J
AU  - Palmer VJ
AD  - Primary Care Research Unit, The Department of General Practice, The University of
      Melbourne, Carlton, Victoria 3056, Australia. vpalmer@unimelb.edu.au
FAU - Yelland, Jane S
AU  - Yelland JS
FAU - Taft, Angela J
AU  - Taft AJ
LA  - eng
PT  - Journal Article
DEP - 20111125
PL  - England
TA  - BMC Public Health
JT  - BMC public health
JID - 100968562
SB  - IM
MH  - Aged
MH  - Beneficence
MH  - Biomedical Research/*ethics
MH  - Depression, Postpartum/diagnosis
MH  - Depressive Disorder/*diagnosis
MH  - Disclosure
MH  - Domestic Violence/*classification
MH  - Female
MH  - Humans
MH  - Informed Consent/ethics/legislation & jurisprudence
MH  - Male
MH  - Mass Screening/adverse effects/*ethics
MH  - Middle Aged
MH  - Moral Obligations
MH  - Personal Autonomy
MH  - Psychometrics/ethics
MH  - Public Health Practice/*ethics
MH  - Risk Factors
MH  - Sexual Partners/*classification
MH  - Treatment Outcome
PMC - PMC3247026
EDAT- 2011/12/30 06:00
MHDA- 2012/05/26 06:00
CRDT- 2011/12/16 06:00
PHST- 2011/12/16 06:00 [entrez]
PHST- 2011/12/30 06:00 [pubmed]
PHST- 2012/05/26 06:00 [medline]
AID - 1471-2458-11-S5-S3 [pii]
AID - 10.1186/1471-2458-11-S5-S3 [doi]
PST - epublish
SO  - BMC Public Health. 2011 Nov 25;11 Suppl 5:S3. doi: 10.1186/1471-2458-11-S5-S3.


PMID- 22203623
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20120517
IS  - 1552-6518 (Electronic)
IS  - 0886-2605 (Linking)
VI  - 27
IP  - 9
DP  - 2012 Jun
TI  - A mixed methods study of participant reaction to domestic violence research in
      Jordan.
PG  - 1655-76
LID - 10.1177/0886260511430383 [doi]
AB  - Research on domestic violence against women has increased considerably over the
      past few decades. Most participants in such studies find the exercise worthwhile 
      and of greater benefit than emotional cost; however, systematic examination of
      participant reaction to research on violence is considerably lacking, especially 
      in the Middle East region. This study begins to fill this gap by examining
      women's reactions to domestic violence research in Jordan and whether a personal 
      history of violence is associated with unfavorable experiences. This sequential
      exploratory mixed methods study included 17 focus group discussions (FGD) with
      women in Amman followed by a survey conducted in reproductive health clinics
      throughout the country (pilot n = 30; survey n = 517). Open coding was used to
      identify the theme related to participant reaction in the FGD data. This
      construct was further examined by the subsequent survey that included dichotomous
      questions inquiring whether the respondent thought the study questions were
      important and whether they were angry or felt resentment as a result of the
      survey. One open-ended question on the survey provided additional qualitative
      data on the theme that was combined with the FGD data. Themes identified in the
      qualitative data pertained to expressions of gratitude and comments on the
      survey's value. Findings of this study indicate that Jordanian women's responses 
      to the research process are similar to women currently represented by the extant 
      literature in that a vast majority of its participants felt that the study was
      important (95%) and it did not evoke anger or resentment (96%). Many even found
      the study to be useful to them personally or to society. Among those who had a
      negative emotional reaction, most still found the research to be important. This 
      study's findings highlight the safety and potential benefits of ethically
      conducted violence research.
FAU - Clark, Cari Jo
AU  - Clark CJ
AD  - University of Minnesota Medical School, Program in Health Disparities
      Research,717 Delaware Street, SE, Ste 166, Minneapolis, MN 55414, USA.
      cjclark@umn.edu
FAU - Shahrouri, Manal
AU  - Shahrouri M
FAU - Halasa, Louma
AU  - Halasa L
FAU - Khalaf, Inaam
AU  - Khalaf I
FAU - Spencer, Rachael
AU  - Spencer R
FAU - Everson-Rose, Susan
AU  - Everson-Rose S
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20111226
PL  - United States
TA  - J Interpers Violence
JT  - Journal of interpersonal violence
JID - 8700910
SB  - IM
MH  - Adult
MH  - Adult Survivors of Child Abuse/*psychology
MH  - *Attitude
MH  - Battered Women/*psychology
MH  - Disclosure
MH  - Female
MH  - Focus Groups
MH  - *Health Surveys
MH  - Humans
MH  - Jordan
MH  - Logistic Models
MH  - *Research Design
MH  - Spouse Abuse/*psychology
EDAT- 2011/12/29 06:00
MHDA- 2012/09/21 06:00
CRDT- 2011/12/29 06:00
PHST- 2011/12/29 06:00 [entrez]
PHST- 2011/12/29 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
AID - 0886260511430383 [pii]
AID - 10.1177/0886260511430383 [doi]
PST - ppublish
SO  - J Interpers Violence. 2012 Jun;27(9):1655-76. doi: 10.1177/0886260511430383. Epub
      2011 Dec 26.


PMID- 22203388
OWN - NLM
STAT- MEDLINE
DCOM- 20120803
LR  - 20120404
IS  - 1049-7323 (Print)
IS  - 1049-7323 (Linking)
VI  - 22
IP  - 5
DP  - 2012 May
TI  - The narrative approach as a learning strategy in the formation of novice
      researchers.
PG  - 700-7
LID - 10.1177/1049732311431443 [doi]
AB  - Novice researchers must be trained to be ethical practitioners. This means more
      than just knowing how to gain ethics approval and being familiar with the codes
      of ethics. Rather, researchers need to develop their ethical awareness,
      perception, and judgment, and their capabilities to reflect and act when actually
      in the field, which we refer to as "situated research ethics." We employ the
      concept of "formation" as a useful pedagogical frame accentuating the importance 
      of integrating knowledge, research skills, and ethical capabilities in research
      practice. We suggest that a narrative approach is consistent with formation, and 
      is useful in research ethics training. This approach uses storytelling and
      engaging with stories to enable the development of ethical know-how in research. 
      We conclude the article by focusing on the benefits and limitations of this
      approach.
FAU - Guillemin, Marilys
AU  - Guillemin M
AD  - Centre for Health and Society, School of Population Health, University of
      Melbourne, Victoria 3010, Australia. m.guillemin@unimelb.edu.au
FAU - Heggen, Kristin
AU  - Heggen K
LA  - eng
PT  - Journal Article
DEP - 20111227
PL  - United States
TA  - Qual Health Res
JT  - Qualitative health research
JID - 9202144
MH  - Ethics, Research
MH  - Humans
MH  - *Learning
MH  - *Narration
MH  - Qualitative Research
MH  - Research Personnel/*education
EDAT- 2011/12/29 06:00
MHDA- 2012/08/04 06:00
CRDT- 2011/12/29 06:00
PHST- 2011/12/29 06:00 [entrez]
PHST- 2011/12/29 06:00 [pubmed]
PHST- 2012/08/04 06:00 [medline]
AID - 1049732311431443 [pii]
AID - 10.1177/1049732311431443 [doi]
PST - ppublish
SO  - Qual Health Res. 2012 May;22(5):700-7. doi: 10.1177/1049732311431443. Epub 2011
      Dec 27.


PMID- 22203385
OWN - NLM
STAT- MEDLINE
DCOM- 20120803
LR  - 20120404
IS  - 1049-7323 (Print)
IS  - 1049-7323 (Linking)
VI  - 22
IP  - 5
DP  - 2012 May
TI  - Developing sensory awareness in qualitative interviewing: a portal into the
      otherwise unexplored.
PG  - 689-99
LID - 10.1177/1049732311431899 [doi]
AB  - Within the social sciences there has been an increased interest in the senses.
      Much of this work has focused on ethnographic methods and has concentrated on
      research about the senses. In this article we focus on interviews and examine the
      value of expanded interviewing strategies that use the senses as access points.
      We argue that a sensory awareness can enrich interviews by offering a portal to
      otherwise unexplored illness or health care experiences which are either too
      difficult to articulate or too intangible to describe. Sensory awareness
      incorporates not only attentiveness to the research environment but also the
      utilization of sensory questions or prompts to gain insight into the research
      experience. We draw from a variety of empirical studies, and offer methodological
      guidance to the researcher while exploring ethical and challenging aspects of
      incorporating sensory awareness into the research interview.
FAU - Harris, Anna
AU  - Harris A
AD  - University of Exeter, Exeter, United Kingdom. annaroseharris@hotmail.com
FAU - Guillemin, Marilys
AU  - Guillemin M
LA  - eng
PT  - Journal Article
DEP - 20111227
PL  - United States
TA  - Qual Health Res
JT  - Qualitative health research
JID - 9202144
MH  - *Awareness
MH  - *Delivery of Health Care
MH  - Humans
MH  - *Interviews as Topic
MH  - *Patient Satisfaction
MH  - Qualitative Research
EDAT- 2011/12/29 06:00
MHDA- 2012/08/04 06:00
CRDT- 2011/12/29 06:00
PHST- 2011/12/29 06:00 [entrez]
PHST- 2011/12/29 06:00 [pubmed]
PHST- 2012/08/04 06:00 [medline]
AID - 1049732311431899 [pii]
AID - 10.1177/1049732311431899 [doi]
PST - ppublish
SO  - Qual Health Res. 2012 May;22(5):689-99. doi: 10.1177/1049732311431899. Epub 2011 
      Dec 27.


PMID- 22200168
OWN - NLM
STAT- MEDLINE
DCOM- 20120830
LR  - 20151119
IS  - 1464-5165 (Electronic)
IS  - 0963-8288 (Linking)
VI  - 34
IP  - 16
DP  - 2012
TI  - Implementation of standardized time limits in sickness insurance and
      return-to-work: experiences of four actors.
PG  - 1404-11
LID - 10.3109/09638288.2011.641667 [doi]
AB  - PURPOSE: In 2008, time limits were introduced in Swedish sickness insurance,
      comprising a pre-defined schedule for return-to-work. The purpose of this study
      was to explore experienced consequences of these time limits. Sick-listed
      persons, physicians, insurance officials and employers were interviewed regarding
      the process of sick-listing, rehabilitation and return-to-work in relation to the
      reform. METHOD: The study comprises qualitative interviews with 11 sick-listed
      persons, 4 insurance officials, 5 employers and 4 physicians (n = 24). RESULTS:
      Physicians, employers, and sick-listed persons described insurance officials as
      increasingly passive, and that responsibility for the process was placed on the
      sick-listed. Several ethical dilemmas were identified, where officials were
      forced to act against their ethical principles. Insurance officials' principle of
      care often clashed with the standardization of the process, that is based on
      principles of egalitarianism and equal treatment. CONCLUSIONS: The cases reported
      in this study suggest that a policy for activation and early return-to-work in
      some cases has had the opposite effect: central actors remain passive and the
      responsibility is placed on the sick-listed, who lacks the strength and knowledge
      to understand and navigate through the system. The standardized insurance system 
      here promoted experiences of procedural injustice, for both officials and
      sick-listed persons.
FAU - Stahl, Christian
AU  - Stahl C
AD  - National Centre for Work and Rehabilitation, Department of Medical and Health
      Sciences, Linkoping University, Sweden. christian.stahl@liu.se
FAU - Mussener, Ulrika
AU  - Mussener U
FAU - Svensson, Tommy
AU  - Svensson T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111226
PL  - England
TA  - Disabil Rehabil
JT  - Disability and rehabilitation
JID - 9207179
SB  - IM
MH  - *Health Care Reform/legislation & jurisprudence
MH  - Humans
MH  - Insurance, Health/*legislation & jurisprudence
MH  - Interviews as Topic
MH  - Physicians
MH  - Qualitative Research
MH  - Rehabilitation, Vocational
MH  - Sick Leave/economics/*statistics & numerical data
MH  - Surveys and Questionnaires
MH  - Sweden
MH  - Time Factors
MH  - Work/economics
MH  - Work Capacity Evaluation
EDAT- 2011/12/28 06:00
MHDA- 2012/08/31 06:00
CRDT- 2011/12/28 06:00
PHST- 2011/12/28 06:00 [entrez]
PHST- 2011/12/28 06:00 [pubmed]
PHST- 2012/08/31 06:00 [medline]
AID - 10.3109/09638288.2011.641667 [doi]
PST - ppublish
SO  - Disabil Rehabil. 2012;34(16):1404-11. doi: 10.3109/09638288.2011.641667. Epub
      2011 Dec 26.


PMID- 22200137
OWN - NLM
STAT- MEDLINE
DCOM- 20120501
LR  - 20111227
IS  - 1369-1627 (Electronic)
IS  - 0954-0261 (Linking)
VI  - 23
IP  - 5
DP  - 2011 Oct
TI  - Transcranial magnetic stimulation, deep brain stimulation and personal identity: 
      ethical questions, and neuroethical approaches for medical practice.
PG  - 476-85
LID - 10.3109/09540261.2011.616189.2011.616189 [doi]
AB  - Neurotechnology provides means to engage micro- and macrostructural networks of
      the brain to both mitigate the manifestations of several neurological and
      psychiatric disorders, and alter cognition and motoric activity. Such capacity
      also generates questions of how these interventions may affect personal identity.
      This paper discusses the ethical implications regarding changes to personal
      identity that arise from the therapeutic use of transcranial magnetic stimulation
      (TMS) and deep brain stimulation (DBS) technologies. In addition, we raise the
      question of whether changes in personal identity, as a side effect of these
      interventions, are ethically acceptable and whether such alterations of
      personality foster patients' sense of well-being and autonomy. First, we provide 
      a series of case vignettes that afford an overview of the ways that various
      neurological interventions can affect personal identity. Second, we offer a brief
      working definition of personal identity in order to delineate an ethical
      framework that we deem necessary for the responsible use of neurostimulation
      technologies. In so doing, we argue that neurostimulation therapy, as a doctoring
      act, should be directed, and adherent to goals of restoring and/or preserving
      patients' personal identity. To this end, we offer an ethical framework that we
      believe enables sound decisions about the right and good use of TMS and DBS.
FAU - Jotterand, Fabrice
AU  - Jotterand F
AD  - Department of Clinical Sciences and Department of Psychiatry, University of Texas
      Southwestern Medical Center, Dallas, Texas, USA.
      fabrice.jotterand@utsouthwestern.edu
FAU - Giordano, James
AU  - Giordano J
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Int Rev Psychiatry
JT  - International review of psychiatry (Abingdon, England)
JID - 8918131
RN  - 0 (Psychotropic Drugs)
SB  - IM
MH  - Cognition
MH  - *Deep Brain Stimulation/adverse effects/ethics/methods
MH  - Humans
MH  - Mental Disorders/psychology/*therapy
MH  - Motor Activity
MH  - Nervous System Diseases/psychology/*therapy
MH  - Neurophysiology/*ethics/methods
MH  - Personal Autonomy
MH  - *Personality/drug effects/radiation effects
MH  - Psychophysiology/*ethics/methods
MH  - Psychotropic Drugs/adverse effects
MH  - Self Concept
MH  - Therapies, Investigational/ethics/methods
MH  - *Transcranial Magnetic Stimulation/adverse effects/ethics/methods
EDAT- 2011/12/28 06:00
MHDA- 2012/05/02 06:00
CRDT- 2011/12/28 06:00
PHST- 2011/12/28 06:00 [entrez]
PHST- 2011/12/28 06:00 [pubmed]
PHST- 2012/05/02 06:00 [medline]
AID - 10.3109/09540261.2011.616189 [doi]
PST - ppublish
SO  - Int Rev Psychiatry. 2011 Oct;23(5):476-85. doi: 10.3109/09540261.2011.616189.


PMID- 22200134
OWN - NLM
STAT- MEDLINE
DCOM- 20120501
LR  - 20111227
IS  - 1369-1627 (Electronic)
IS  - 0954-0261 (Linking)
VI  - 23
IP  - 5
DP  - 2011 Oct
TI  - Applications of transcranial magnetic stimulation (TMS) in child and adolescent
      psychiatry.
PG  - 445-53
LID - 10.3109/09540261.2011.623688 [doi]
AB  - Transcranial magnetic stimulation (TMS) is emerging as a new treatment and
      neurophysiological research tool for psychiatric disorders. Recent publications
      suggest that this modality will also serve as a treatment and research tool in
      child and adolescent psychiatry. Current reports on therapeutic trials of
      repetitive transcranial magnetic stimulation (rTMS) in adolescents have primarily
      focused on depression. However, other pilot work involves the treatment of
      attention-deficit/hyperactivity disorder (ADHD), autism and schizophrenia.
      Neurophysiological studies typically utilize single and paired-pulse TMS
      paradigms which index cortical excitability and inhibition. Initial studies have 
      focused on ADHD, autism, and depression. General knowledge regarding TMS among
      child and adolescent psychiatrists is lacking. The aim of this review is to
      provide an overview of TMS in the context of child and adolescent psychiatry,
      discuss recent therapeutic and neurophysiological studies, and examine relevant
      ethical considerations.
FAU - Croarkin, Paul E
AU  - Croarkin PE
AD  - Mayo Clinic, Rochester, Minnesota, USA. Croarkin.paul@mayo.edu
FAU - Wall, Christopher A
AU  - Wall CA
FAU - Lee, Jon
AU  - Lee J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Int Rev Psychiatry
JT  - International review of psychiatry (Abingdon, England)
JID - 8918131
SB  - IM
MH  - Adolescent
MH  - Adolescent Behavior/radiation effects
MH  - Attention Deficit Disorder with Hyperactivity/physiopathology/*therapy
MH  - Autistic Disorder/physiopathology/*therapy
MH  - Child
MH  - Child Behavior/radiation effects
MH  - Depressive Disorder/physiopathology/*therapy
MH  - Humans
MH  - Minority Health/ethics
MH  - Neurophysiology/ethics/methods
MH  - Psychophysiology/ethics/methods
MH  - Randomized Controlled Trials as Topic
MH  - Schizophrenia/physiopathology/*therapy
MH  - Therapies, Investigational/ethics/methods
MH  - Transcranial Magnetic Stimulation/*methods
EDAT- 2011/12/28 06:00
MHDA- 2012/05/02 06:00
CRDT- 2011/12/28 06:00
PHST- 2011/12/28 06:00 [entrez]
PHST- 2011/12/28 06:00 [pubmed]
PHST- 2012/05/02 06:00 [medline]
AID - 10.3109/09540261.2011.623688 [doi]
PST - ppublish
SO  - Int Rev Psychiatry. 2011 Oct;23(5):445-53. doi: 10.3109/09540261.2011.623688.


PMID- 22198582
OWN - NLM
STAT- MEDLINE
DCOM- 20120719
LR  - 20211021
IS  - 0390-5616 (Print)
IS  - 0390-5616 (Linking)
VI  - 55
IP  - 4
DP  - 2011 Dec
TI  - Neurotransplantation: lux et veritas, fiction or reality?
PG  - 297-304
AB  - Neurotransplantation remains a much-debated frontier in contemporary neurosurgery
      and neuroscience, with roots dating to the late 19th century. Contemporary
      applications are far-reaching, and ongoing laboratory research and clinical
      trials seek to define the mechanisms at play in neurotransplant engraftment and
      growth, while advancing the field forward into the 21st century. Neural
      transplantation therapy remains an attractive idea for treating central nervous
      system (CNS) and peripheral nervous system (PNS) pathologies. Phase I and phase
      II clinical trials assessing safety and efficacy are currently underway for
      various disorders. The remainder of this review will focus on ongoing clinical
      trials and more recent research advances involving neural transplantation therapy
      for neuronal death, axonal injury, peripheral nerve lesions, and cancer. The
      field of neural transplantation, while promising, is not without ethical and
      scientific dilemmas; this review will conclude with a discussion of the
      challenges researchers and clinicians face as the field of neural transplantation
      moves forward.
FAU - Pendleton, C
AU  - Pendleton C
AD  - Department of Neurosurgery, Johns Hopkins University, Baltimore, MD, USA.
FAU - Ahmed, I
AU  - Ahmed I
FAU - Quinones-Hinojosa, A
AU  - Quinones-Hinojosa A
LA  - eng
GR  - P30 CA006973/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - J Neurosurg Sci
JT  - Journal of neurosurgical sciences
JID - 0432557
SB  - IM
MH  - Brain Neoplasms/*surgery
MH  - Humans
MH  - Neurodegenerative Diseases/*surgery
MH  - Neurons/*transplantation
MH  - Spinal Cord Injuries/*surgery
MH  - Stroke/*surgery
PMC - PMC4659364
MID - NIHMS736300
EDAT- 2011/12/27 06:00
MHDA- 2012/07/20 06:00
CRDT- 2011/12/27 06:00
PHST- 2011/12/27 06:00 [entrez]
PHST- 2011/12/27 06:00 [pubmed]
PHST- 2012/07/20 06:00 [medline]
AID - R38112357 [pii]
PST - ppublish
SO  - J Neurosurg Sci. 2011 Dec;55(4):297-304.


PMID- 22197581
OWN - NLM
STAT- MEDLINE
DCOM- 20120516
LR  - 20120131
IS  - 1873-2518 (Electronic)
IS  - 0264-410X (Linking)
VI  - 30
IP  - 6
DP  - 2012 Feb 1
TI  - Evidence-based decision making for vaccines: the need for an ethical foundation.
PG  - 1009-13
LID - 10.1016/j.vaccine.2011.12.053 [doi]
AB  - Evidence-based decision making (EBDM) is a tool to assess the value of medical
      interventions by weighing costs and health outcomes that has increasingly been
      applied to vaccines. However, many of the ethical considerations that support
      EBDM when used to evaluate therapeutic care do not readily translate to
      prevention. This mismatch can result in policy decisions that produce
      unanticipated negative consequences, including public resistance. In its emphasis
      on quantifiable outcomes, EBDM invokes the ethical principle of
      rule-utilitarianism, which values the optimal long-run balance of benefit over
      harm. Vaccines raise a number of competing ethical concerns in ways that
      individual medical treatments do not. They rely on widespread compliance for
      effectiveness, which can limit individual autonomy, emphasize population over
      individual effects, which can obscure the imperative of beneficence to help the
      vulnerable, require a just allocation process within populations, and sometimes
      challenge strong social norms. For EBDM to effectively guide vaccine policy
      makers, such as the Advisory Committee on Immunization Practices (ACIP) in the
      United States, an ethical foundation is needed that systematically considers all 
      relevant values and transparently places vaccination recommendations in the
      context of social norms and individual concerns.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Field, Robert I
AU  - Field RI
AD  - Drexel University Earle Mack School of Law and School of Public Health, 3320
      Market Street, Philadelphia, PA 19104, USA. robert.field@drexel.edu
FAU - Caplan, Arthur L
AU  - Caplan AL
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111221
PL  - Netherlands
TA  - Vaccine
JT  - Vaccine
JID - 8406899
RN  - 0 (Vaccines)
SB  - IM
MH  - *Decision Making
MH  - Humans
MH  - United States
MH  - Vaccination/*ethics
MH  - Vaccines/*administration & dosage/*immunology
EDAT- 2011/12/27 06:00
MHDA- 2012/05/17 06:00
CRDT- 2011/12/27 06:00
PHST- 2011/10/12 00:00 [received]
PHST- 2011/12/08 00:00 [revised]
PHST- 2011/12/09 00:00 [accepted]
PHST- 2011/12/27 06:00 [entrez]
PHST- 2011/12/27 06:00 [pubmed]
PHST- 2012/05/17 06:00 [medline]
AID - S0264-410X(11)01988-8 [pii]
AID - 10.1016/j.vaccine.2011.12.053 [doi]
PST - ppublish
SO  - Vaccine. 2012 Feb 1;30(6):1009-13. doi: 10.1016/j.vaccine.2011.12.053. Epub 2011 
      Dec 21.


PMID- 22197455
OWN - NLM
STAT- MEDLINE
DCOM- 20121009
LR  - 20171116
IS  - 1532-1983 (Electronic)
IS  - 0261-5614 (Linking)
VI  - 31
IP  - 3
DP  - 2012 Jun
TI  - Variations on cardiovascular risk factors in metabolic syndrome after consume of 
      a citrus-based juice.
PG  - 372-7
LID - 10.1016/j.clnu.2011.11.014 [doi]
AB  - BACKGROUND & AIMS: Inflammation and oxidative stress plays a critical role in
      cardiovascular disease and metabolic syndrome often occurs with these two
      variables. The aim of the study is to estimate variations on cardiovascular risk 
      factors in Metabolic Syndrome patients after consume of a citrus-based juice
      compared with control groups. METHODS: The study comprised 20 healthy subjects
      and 33 patients with Metabolic Syndrome. 18 patients consume daily 300 mL of a
      citrus-based juice during 6 month and 15 patients consume 300 mL of a placebo
      beverage. The control group consumes a citrus-based juice. Before, at fourth
      month and at sixth month after treatment the following parameters were
      determined: lipid profile, oxidized LDL, C-Reactive Protein and Homocysteine. The
      study was carried out in accordance with the Helsinki Declaration, and the
      Ethical Committee of the San Antonio Catholic University and approved the
      protocol (6 November 2006, register number: 1424). RESULTS: After six months of
      citrus-based juice consuming, there is significant differences at 95% confidence 
      in oxidized LDL, C-Reactive Protein, and Homocysteine in Metabolic Syndrome
      patients who consume citrus-based juice. We have not found significant
      differences in other groups. CONCLUSIONS: Consume of citrus-based juice improve
      lipid profile and inflammation markers in Metabolic Syndrome patients.
CI  - Copyright (c) 2011 Elsevier Ltd and European Society for Clinical Nutrition and
      Metabolism. All rights reserved.
FAU - Mulero, Juana
AU  - Mulero J
AD  - Department of Food Technology and Nutrition, Catholic University of San Antonio, 
      Murcia 30107, Spain. jmulero@pdi.ucam.edu
FAU - Bernabe, Juana
AU  - Bernabe J
FAU - Cerda, Begona
AU  - Cerda B
FAU - Garcia-Viguera, Cristina
AU  - Garcia-Viguera C
FAU - Moreno, Diego A
AU  - Moreno DA
FAU - Albaladejo, Maria Dolores
AU  - Albaladejo MD
FAU - Aviles, Francisco
AU  - Aviles F
FAU - Parra, Soledad
AU  - Parra S
FAU - Abellan, Jose
AU  - Abellan J
FAU - Zafrilla, Pilar
AU  - Zafrilla P
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111223
PL  - England
TA  - Clin Nutr
JT  - Clinical nutrition (Edinburgh, Scotland)
JID - 8309603
RN  - 0 (Antioxidants)
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (Plant Extracts)
RN  - 0 (oxidized low density lipoprotein)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Aged
MH  - Antioxidants/administration & dosage/analysis
MH  - *Beverages/analysis
MH  - C-Reactive Protein/analysis
MH  - Cardiovascular Diseases/epidemiology/etiology/*prevention & control
MH  - Citrus/*chemistry
MH  - Female
MH  - Fruit/*chemistry
MH  - Homocysteine/blood
MH  - Humans
MH  - Lipid Peroxidation
MH  - Lipoproteins, LDL/blood
MH  - Male
MH  - Metabolic Syndrome/blood/*diet therapy/immunology/physiopathology
MH  - Middle Aged
MH  - Photinia/chemistry
MH  - Plant Extracts/chemistry
MH  - Risk Factors
MH  - Spain/epidemiology
MH  - Time Factors
EDAT- 2011/12/27 06:00
MHDA- 2012/10/10 06:00
CRDT- 2011/12/27 06:00
PHST- 2011/09/27 00:00 [received]
PHST- 2011/11/17 00:00 [revised]
PHST- 2011/11/22 00:00 [accepted]
PHST- 2011/12/27 06:00 [entrez]
PHST- 2011/12/27 06:00 [pubmed]
PHST- 2012/10/10 06:00 [medline]
AID - S0261-5614(11)00226-3 [pii]
AID - 10.1016/j.clnu.2011.11.014 [doi]
PST - ppublish
SO  - Clin Nutr. 2012 Jun;31(3):372-7. doi: 10.1016/j.clnu.2011.11.014. Epub 2011 Dec
      23.


PMID- 22197414
OWN - NLM
STAT- MEDLINE
DCOM- 20140403
LR  - 20211021
IS  - 1532-2793 (Electronic)
IS  - 0260-6917 (Linking)
VI  - 33
IP  - 5
DP  - 2013 May
TI  - Storytellers as partners in developing a genetics education resource for health
      professionals.
PG  - 518-24
LID - 10.1016/j.nedt.2011.11.019 [doi]
LID - S0260-6917(11)00320-0 [pii]
AB  - Advances in genetics are bringing unprecedented opportunities for understanding
      health and disease, developing new therapies and changes in healthcare practice. 
      Many nurses and midwives lack competence and confidence in integrating genetics
      into professional practice. One approach to enhance understanding of genetics is 
      to simulate clinical exposure through storytelling. Stories are acknowledged as a
      powerful learning tool, being understandable and memorable, stimulating critical 
      thinking, and linking theory to practice. Telling Stories, Understanding Real
      Life Genetics is a freely accessible website that sets people's stories within an
      education framework. The links between the stories and professional practice are 
      made explicit and additional features support learning and teaching. Care of the 
      storytellers within an ethical framework is of paramount importance. Storytellers
      are viewed as partners in the project. The challenges encountered include
      preserving the authentic voice and dignity of the storyteller. Project team
      members have also experienced 'professional shame' when negative experiences have
      been recounted, and the stories have had an impact on the team. The experience of
      working with storytellers has been positive. The storytellers want to be heard so
      that others will benefit from their stories. They serve as a reminder of why this
      work is important.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Kirk, Maggie
AU  - Kirk M
AD  - NHS National Genetics Education and Development Centre, University of Glamorgan, 
      Pontypridd, Wales, United Kingdom. mkirk@glam.ac.uk
FAU - Tonkin, Emma
AU  - Tonkin E
FAU - Skirton, Heather
AU  - Skirton H
FAU - McDonald, Kevin
AU  - McDonald K
FAU - Cope, Buddug
AU  - Cope B
FAU - Morgan, Rhian
AU  - Morgan R
LA  - eng
GR  - Department of Health/United Kingdom
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111223
PL  - Scotland
TA  - Nurse Educ Today
JT  - Nurse education today
JID - 8511379
MH  - *Audiovisual Aids
MH  - Genetics, Medical/*education
MH  - Humans
MH  - *Internet
MH  - *Narration
MH  - Program Development
MH  - Program Evaluation
MH  - United Kingdom
MH  - User-Computer Interface
PMC - PMC3661988
EDAT- 2011/12/27 06:00
MHDA- 2014/04/04 06:00
CRDT- 2011/12/27 06:00
PHST- 2011/08/21 00:00 [received]
PHST- 2011/11/18 00:00 [accepted]
PHST- 2011/12/27 06:00 [entrez]
PHST- 2011/12/27 06:00 [pubmed]
PHST- 2014/04/04 06:00 [medline]
AID - S0260-6917(11)00320-0 [pii]
AID - 10.1016/j.nedt.2011.11.019 [doi]
PST - ppublish
SO  - Nurse Educ Today. 2013 May;33(5):518-24. doi: 10.1016/j.nedt.2011.11.019. Epub
      2011 Dec 23.


PMID- 22197221
OWN - NLM
STAT- MEDLINE
DCOM- 20130820
LR  - 20220317
IS  - 1873-4898 (Electronic)
IS  - 1477-5131 (Linking)
VI  - 9
IP  - 1
DP  - 2013 Feb
TI  - Decision making among different treatment options for neurologically impaired
      boys with undescended testis: a multinational pediatric survey.
PG  - 42-5
LID - 10.1016/j.jpurol.2011.11.009 [doi]
LID - S1477-5131(11)00285-3 [pii]
AB  - OBJECTIVE: To determine the attitude of referring pediatricians towards the
      decision of treatment modalities for undescended testis (UDT) in neurologic
      impaired boys (NIB). METHODS AND MATERIALS: An online questionnaire was offered
      to registered pediatricians in Austria and Germany for online completion.
      RESULTS: 221 male (61.6%) and 138 female (38.4%) pediatricians completed the
      survey; 326 (90.8%) believe that UDT should be treated according to national
      guidelines; 31 (8.6%) believe that UDT should be treated according to the
      parental wish, whereas only 2 (0.6%) tend to no treatment at all. Tumor
      prophylaxis, further sexual life, legal concerns, risks of anesthesia, and the
      choice of the parents have major impact on the perception of UDT. Moreover,
      fertility and limited life expectancy seem to be of minor importance only. In
      general, Pearson chi2 test could not identify age and sex of pediatricians as
      significant predictor of how the importance of the treatment of UDT is appraised.
      CONCLUSION: From the pediatric point of view UDT in NIB is an important issue and
      should be treated according to guidelines. Nevertheless, this study indicates the
      problems in decision-making and choosing the best management for UDT in NIB.
      Undoubtedly, further ethical discussion is needed to optimize treatment of UDT in
      NIB.
CI  - Copyright (c) 2011 Journal of Pediatric Urology Company. Published by Elsevier
      Ltd. All rights reserved.
FAU - Springer, Alexander
AU  - Springer A
AD  - Department of Pediatric Surgery, Medical University of Vienna, Wahringer Gurtel
      18-20, 1090 Vienna, Austria. alexander.springer@meduniwien.ac.at
FAU - Kidger, Elizabeth
AU  - Kidger E
FAU - Krois, Wilfried
AU  - Krois W
FAU - Fengler, David
AU  - Fengler D
FAU - Reck, Carlos A
AU  - Reck CA
FAU - Horcher, Ernst
AU  - Horcher E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111221
PL  - England
TA  - J Pediatr Urol
JT  - Journal of pediatric urology
JID - 101233150
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Austria/epidemiology
MH  - Cerebral Palsy/epidemiology/*psychology
MH  - Cryptorchidism/epidemiology/psychology/*surgery
MH  - Female
MH  - Germany/epidemiology
MH  - *Health Care Surveys
MH  - Humans
MH  - Infant
MH  - Male
MH  - Middle Aged
MH  - Orchiopexy/psychology
MH  - Parents/psychology
MH  - Pediatrics/*standards
MH  - Practice Guidelines as Topic
MH  - Professional Practice/standards
MH  - Quality of Life
MH  - Risk Factors
MH  - Young Adult
EDAT- 2011/12/27 06:00
MHDA- 2013/08/21 06:00
CRDT- 2011/12/27 06:00
PHST- 2011/06/07 00:00 [received]
PHST- 2011/11/16 00:00 [accepted]
PHST- 2011/12/27 06:00 [entrez]
PHST- 2011/12/27 06:00 [pubmed]
PHST- 2013/08/21 06:00 [medline]
AID - S1477-5131(11)00285-3 [pii]
AID - 10.1016/j.jpurol.2011.11.009 [doi]
PST - ppublish
SO  - J Pediatr Urol. 2013 Feb;9(1):42-5. doi: 10.1016/j.jpurol.2011.11.009. Epub 2011 
      Dec 21.


PMID- 22196749
OWN - NLM
STAT- MEDLINE
DCOM- 20120511
LR  - 20211021
IS  - 1475-925X (Electronic)
IS  - 1475-925X (Linking)
VI  - 10
DP  - 2011 Dec 23
TI  - Model-based PEEP optimisation in mechanical ventilation.
PG  - 111
LID - 10.1186/1475-925X-10-111 [doi]
AB  - BACKGROUND: Acute Respiratory Distress Syndrome (ARDS) patients require
      mechanical ventilation (MV) for breathing support. Patient-specific PEEP is
      encouraged for treating different patients but there is no well established
      method in optimal PEEP selection. METHODS: A study of 10 patients diagnosed with 
      ALI/ARDS whom underwent recruitment manoeuvre is carried out. Airway pressure and
      flow data are used to identify patient-specific constant lung elastance (E lung) 
      and time-variant dynamic lung elastance (E drs) at each PEEP level (increments of
      5 cm H2O), for a single compartment linear lung model using integral-based
      methods. Optimal PEEP is estimated using E lung versus PEEP, Edrs-Pressure curve 
      and E drs Area at minimum elastance (maximum compliance) and the inflection of
      the curves (diminishing return). Results are compared to clinically selected PEEP
      values. The trials and use of the data were approved by the New Zealand South
      Island Regional Ethics Committee. RESULTS: Median absolute percentage fitting
      error to the data when estimating time-variant E drs is 0.9% (IQR = 0.5-2.4) and 
      5.6% [IQR: 1.8-11.3] when estimating constant E lung. Both E lung and E drs
      decrease with PEEP to a minimum, before rising, and indicating potential
      over-inflation. Median E drs over all patients across all PEEP values was 32.2
      cmH2O/l [IQR: 26.1-46.6], reflecting the heterogeneity of ALI/ARDS patients, and 
      their response to PEEP, that complicates standard approaches to PEEP selection.
      All E drs-Pressure curves have a clear inflection point before minimum E drs,
      making PEEP selection straightforward. Model-based selected PEEP using the
      proposed metrics were higher than clinically selected values in 7/10 cases.
      CONCLUSION: Continuous monitoring of the patient-specific E lung and E drs and
      minimally invasive PEEP titration provide a unique, patient-specific and
      physiologically relevant metric to optimize PEEP selection with minimal
      disruption of MV therapy.
FAU - Chiew, Yeong Shiong
AU  - Chiew YS
AD  - Department of Mechanical Engineering, University of Canterbury, New Zealand.
FAU - Chase, J Geoffrey
AU  - Chase JG
FAU - Shaw, Geoffrey M
AU  - Shaw GM
FAU - Sundaresan, Ashwath
AU  - Sundaresan A
FAU - Desaive, Thomas
AU  - Desaive T
LA  - eng
PT  - Journal Article
DEP - 20111223
PL  - England
TA  - Biomed Eng Online
JT  - Biomedical engineering online
JID - 101147518
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Elasticity
MH  - Female
MH  - Humans
MH  - Lung/physiopathology
MH  - Male
MH  - Middle Aged
MH  - *Models, Biological
MH  - Positive-Pressure Respiration/*methods
MH  - Precision Medicine
MH  - Respiration
MH  - *Respiration, Artificial
MH  - Respiratory Distress Syndrome/physiopathology/therapy
MH  - Time Factors
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC3339371
EDAT- 2011/12/27 06:00
MHDA- 2012/05/12 06:00
CRDT- 2011/12/27 06:00
PHST- 2011/11/07 00:00 [received]
PHST- 2011/12/23 00:00 [accepted]
PHST- 2011/12/27 06:00 [entrez]
PHST- 2011/12/27 06:00 [pubmed]
PHST- 2012/05/12 06:00 [medline]
AID - 1475-925X-10-111 [pii]
AID - 10.1186/1475-925X-10-111 [doi]
PST - epublish
SO  - Biomed Eng Online. 2011 Dec 23;10:111. doi: 10.1186/1475-925X-10-111.


PMID- 22195419
OWN - NLM
STAT- MEDLINE
DCOM- 20120119
LR  - 20111226
IS  - 0898-2759 (Print)
IS  - 0898-2759 (Linking)
VI  - 37
IP  - 6
DP  - 2011 Nov-Dec
TI  - Web-based clinical ethics consultation: a model for hospital-based practice.
PG  - 62-4
FAU - Smith, Lauren B
AU  - Smith LB
AD  - Department of Pathology, University of Michigan, Ann Arbor, Mich., USA.
FAU - Barnosky, Andrew
AU  - Barnosky A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Physician Exec
JT  - Physician executive
JID - 8610398
MH  - Ethics Committees/*organization & administration
MH  - Hospitals, University
MH  - *Internet
MH  - Michigan
MH  - *Models, Organizational
MH  - Organizational Case Studies
EDAT- 2011/12/27 06:00
MHDA- 2012/01/20 06:00
CRDT- 2011/12/27 06:00
PHST- 2011/12/27 06:00 [entrez]
PHST- 2011/12/27 06:00 [pubmed]
PHST- 2012/01/20 06:00 [medline]
PST - ppublish
SO  - Physician Exec. 2011 Nov-Dec;37(6):62-4.


PMID- 22195386
OWN - NLM
STAT- MEDLINE
DCOM- 20120110
LR  - 20211021
IS  - 0309-3913 (Print)
IS  - 0309-3913 (Linking)
VI  - 40
IP  - 2
DP  - 2011 Jun
TI  - An appraisal of the process of protocol review by an ethics review conmmittee in 
      a tertiary institution in Ibadan.
PG  - 163-9
AB  - It is a well established norm that biomedical research involving human
      participants must conform to acceptable scientific principles and international
      codes of research ethics. The University of Ibadan/University College Hospital
      Health Research Ethics Committee (UI/UCH HREC) is the body that plays an
      oversight role and performs the function of a third party independent review of
      research protocols submitted by staff and students of the two institutions. A
      6-year (2002-2007) retrospective audit of the protocols submitted to the HREC was
      performed to determine the profile of the lead investigator, sources of funding
      for the research and the duration for review using a 25 item questionnaire. A
      total of 752 protocols were submitted, 618 protocols (82%) were approved while 38
      protocols were not approved. The principal investigators were mainly postgraduate
      students (67.1%) while academic staff constituted 21.3%. The average time from
      submission to approval was approximately 21 weeks (95% CI: 20-23 weeks). The
      period from submission to approval is significantly affected by the number of
      revision required and the funding agent (p < 0.05); it took a shorter time to
      review internationally funded research.
FAU - Eyelade, O R
AU  - Eyelade OR
AD  - Department of Anaesthesia, College of Medicine, University of Ibadan, Ibadan,
      Nigeria. dryinka@yahoo.com
FAU - Ajuwon, A J
AU  - Ajuwon AJ
FAU - Adebamowo, C A
AU  - Adebamowo CA
LA  - eng
GR  - R25 TW007091-04/TW/FIC NIH HHS/United States
GR  - D43 TW007091/TW/FIC NIH HHS/United States
GR  - R25 TW007091-06/TW/FIC NIH HHS/United States
GR  - R25 TW007091-05/TW/FIC NIH HHS/United States
GR  - R25 TW007091/TW/FIC NIH HHS/United States
GR  - R25 TW007091-02/TW/FIC NIH HHS/United States
GR  - R25 TW007091-08/TW/FIC NIH HHS/United States
GR  - R25 TW007091-03/TW/FIC NIH HHS/United States
GR  - R25 TW007091-07/TW/FIC NIH HHS/United States
GR  - R25 TW007091-01/TW/FIC NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - Nigeria
TA  - Afr J Med Med Sci
JT  - African journal of medicine and medical sciences
JID - 7801013
SB  - IM
MH  - Biomedical Research/*standards
MH  - Clinical Protocols/*standards
MH  - Ethical Review
MH  - *Ethics Committees, Research/organization & administration/statistics & numerical
      data
MH  - *Ethics, Research
MH  - Hospitals, Teaching
MH  - Humans
MH  - Medical Audit
MH  - Nigeria
MH  - Retrospective Studies
MH  - Surveys and Questionnaires
MH  - Time Factors
PMC - PMC3333792
MID - NIHMS370628
EDAT- 2011/12/27 06:00
MHDA- 2012/01/11 06:00
CRDT- 2011/12/27 06:00
PHST- 2011/12/27 06:00 [entrez]
PHST- 2011/12/27 06:00 [pubmed]
PHST- 2012/01/11 06:00 [medline]
PST - ppublish
SO  - Afr J Med Med Sci. 2011 Jun;40(2):163-9.


PMID- 22195380
OWN - NLM
STAT- MEDLINE
DCOM- 20120110
LR  - 20111226
IS  - 0309-3913 (Print)
IS  - 0309-3913 (Linking)
VI  - 40
IP  - 2
DP  - 2011 Jun
TI  - Survival rates of two atraumatic restorative treatment (ART) types in occlusal
      carious permanent teeth after two years.
PG  - 127-34
AB  - OBJECTIVE: To compare survival rates of Atraumatic Restorative Treatment (ART)
      restorations placed with and without conditioners in occlusal cariouspermanent
      teeth after two years. MATERIAL AND METHODS: The study was an experimental study 
      among children, mean age 13.1 +/- 3.0 years. Two types of ART restorations were
      randomly placed on 186 occlusal carious permanent teeth on contralateral sides
      using split mouth design. Ethical clearance to conduct the study was obtained
      from the UI/UCH Review Committee. ART was performed using GC Fuji IX GP and teeth
      that were conditioned with GC Dentine Conditioner. Time taken to place
      restorations and average material cost were recorded. Follow-up of subjects to
      evaluate integrity of restorations was conducted at 6 monthly intervals by one
      independent examiner. Proportions and percentages were generated; student t-test 
      was used to compare means. Cumulative survival rates were determined by the coded
      scores and standard criteria for evaluating ART restorations. RESULTS: There was 
      no significant difference in the mean time for placing ART restorations with or
      without conditioners and in the cumulative survival rates of both treatment types
      after 2 years (p > 0.05). CONCLUSION: ART restorations placed without tooth
      conditioners can achieve similar result as those placed with conditioners.
FAU - Ibiyemi, O
AU  - Ibiyemi O
AD  - Department of Periodontology and Community Dentistry, Faculty of Dentistry,
      College of Medicine, University of Ibadan, Ibadan, Nigeria.
      shola_ibiyemi@yahoo.com
FAU - Bankole, O O
AU  - Bankole OO
FAU - Oke, G A
AU  - Oke GA
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Nigeria
TA  - Afr J Med Med Sci
JT  - African journal of medicine and medical sciences
JID - 7801013
RN  - 0 (Fuji II LC cement)
RN  - 0 (Glass Ionomer Cements)
RN  - 0 (Resins, Synthetic)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Dental Atraumatic Restorative Treatment/*methods
MH  - Dental Caries/mortality/*therapy
MH  - Dental Cavity Preparation/*methods
MH  - Dental Restoration Failure
MH  - Dental Restoration, Permanent/*methods/statistics & numerical data
MH  - Female
MH  - Follow-Up Studies
MH  - Glass Ionomer Cements
MH  - Hospitals, Teaching
MH  - Humans
MH  - Infant
MH  - Male
MH  - Nigeria/epidemiology
MH  - Resins, Synthetic
MH  - Survival Rate
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2011/12/27 06:00
MHDA- 2012/01/11 06:00
CRDT- 2011/12/27 06:00
PHST- 2011/12/27 06:00 [entrez]
PHST- 2011/12/27 06:00 [pubmed]
PHST- 2012/01/11 06:00 [medline]
PST - ppublish
SO  - Afr J Med Med Sci. 2011 Jun;40(2):127-34.


PMID- 22195214
OWN - NLM
STAT- MEDLINE
DCOM- 20130225
LR  - 20220409
IS  - 1942-597X (Electronic)
IS  - 1559-4076 (Linking)
VI  - 2011
DP  - 2011
TI  - Ethics of implementing Electronic Health Records in developing countries: points 
      to consider.
PG  - 1499-505
AB  - Electronic Health Record systems (EHRs) are increasingly being used in many
      developing countries, several of which have moved beyond isolated pilot projects 
      to active large-scale implementation as part of their national health strategies.
      Despite growing enthusiasm for adopting EHRs in resource poor settings, almost no
      attention has been paid to the ethical issues that might arise. In this article
      we argue that these ethical issues should be addressed now if EHRs are to be
      appropriately implemented in these settings. We take a systematic approach guided
      by a widely accepted ethical framework currently in use for developing countries 
      to first describe the ethical issues, and then propose a set of 'Points to
      Consider' to guide further thinking and decision-making.
FAU - Were, Martin C
AU  - Were MC
AD  - Regenstrief Institute, Inc., Indianapolis, IN, USA.
FAU - Meslin, Eric M
AU  - Meslin EM
LA  - eng
GR  - UL1 RR025761/RR/NCRR NIH HHS/United States
GR  - 1 R25 TW008183-01/TW/FIC NIH HHS/United States
GR  - S07 TW008850/TW/FIC NIH HHS/United States
GR  - 1S07TW008850-01/TW/FIC NIH HHS/United States
GR  - UL1RR025761-01/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20111022
PL  - United States
TA  - AMIA Annu Symp Proc
JT  - AMIA ... Annual Symposium proceedings. AMIA Symposium
JID - 101209213
SB  - IM
MH  - Computer Security
MH  - *Developing Countries
MH  - Electronic Health Records/economics/*ethics
MH  - Humans
MH  - Informed Consent
MH  - Ownership
MH  - Risk Assessment
MH  - Social Justice
PMC - PMC3243215
EDAT- 2011/12/24 06:00
MHDA- 2013/02/26 06:00
CRDT- 2011/12/24 06:00
PHST- 2011/12/24 06:00 [entrez]
PHST- 2011/12/24 06:00 [pubmed]
PHST- 2013/02/26 06:00 [medline]
PST - ppublish
SO  - AMIA Annu Symp Proc. 2011;2011:1499-505. Epub 2011 Oct 22.


PMID- 22194905
OWN - NLM
STAT- MEDLINE
DCOM- 20120827
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 6
IP  - 12
DP  - 2011
TI  - Randomized controlled trials of HIV/AIDS prevention and treatment in Africa:
      results from the Cochrane HIV/AIDS Specialized Register.
PG  - e28759
LID - 10.1371/journal.pone.0028759 [doi]
AB  - INTRODUCTION: To effectively address HIV/AIDS in Africa, evidence on preventing
      new infections and providing effective treatment is needed. Ideally, decisions on
      which interventions are effective should be based on evidence from randomized
      controlled trials (RCTs). Our previous research described African RCTs of
      HIV/AIDS reported between 1987 and 2003. This study updates that analysis with
      RCTs published between 2004 and 2008. OBJECTIVES: To describe RCTs of HIV/AIDS
      conducted in Africa and reported between 2004 and 2008. METHODS: We searched the 
      Cochrane HIV/AIDS Specialized Register in September 2009. Two researchers
      independently evaluated studies for inclusion and extracted data using
      standardized forms. Details included location of trials, interventions,
      methodological quality, location of principal investigators and funders. RESULTS:
      Our search identified 834 RCTs, with 68 conducted in Africa. Forty-three assessed
      prevention-interventions and 25 treatment-interventions. Fifteen of the 43
      prevention RCTs focused on preventing mother-to-child HIV transmission. Thirteen 
      of the 25 treatment trials focused on opportunistic infections. Trials were
      conducted in 16 countries with most in South Africa (20), Zambia (12) and
      Zimbabwe (9). The median sample size was 628 (range 33-9645). Methods used for
      the generation of the allocation sequence and allocation concealment were
      adequate in 38 and 32 trials, respectively, and 58 reports included a CONSORT
      recommended flow diagram. Twenty-nine principal investigators resided in the
      United States of America (USA) and 18 were from African countries. Trials were
      co-funded by different agencies with most of the funding obtained from USA
      governmental and non-governmental agencies. Nineteen pharmaceutical companies
      provided partial funding to 15 RCTs and African agencies co-funded 17 RCTs.
      Ethical approval was reported in 65 trials and informed consent in 61 trials.
      CONCLUSION: Prevention trials dominate the trial landscape in Africa. Of note,
      few principal investigators and funders are from Africa. These findings mirror
      our previous work and continue to indicate a need for strengthening trial
      research capacity in Africa.
FAU - Zani, Babalwa
AU  - Zani B
AD  - South African Cochrane Centre, Medical Research Council of South Africa, Cape
      Town, South Africa. bzani@mrc.ac.za
FAU - Pienaar, Elizabeth D
AU  - Pienaar ED
FAU - Oliver, Joy
AU  - Oliver J
FAU - Siegfried, Nandi
AU  - Siegfried N
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20111215
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/epidemiology/*prevention & control/*therapy
MH  - Africa
MH  - Early Termination of Clinical Trials
MH  - Humans
MH  - Informed Consent
MH  - Organizations/economics/statistics & numerical data
MH  - Randomized Controlled Trials as Topic/economics/ethics/*statistics & numerical
      data
MH  - Registries/*statistics & numerical data
MH  - Sample Size
MH  - Statistics as Topic
MH  - Treatment Outcome
PMC - PMC3240627
EDAT- 2011/12/24 06:00
MHDA- 2012/08/28 06:00
CRDT- 2011/12/24 06:00
PHST- 2011/02/11 00:00 [received]
PHST- 2011/11/14 00:00 [accepted]
PHST- 2011/12/24 06:00 [entrez]
PHST- 2011/12/24 06:00 [pubmed]
PHST- 2012/08/28 06:00 [medline]
AID - 10.1371/journal.pone.0028759 [doi]
AID - PONE-D-11-03060 [pii]
PST - ppublish
SO  - PLoS One. 2011;6(12):e28759. doi: 10.1371/journal.pone.0028759. Epub 2011 Dec 15.


PMID- 22194873
OWN - NLM
STAT- MEDLINE
DCOM- 20120827
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 6
IP  - 12
DP  - 2011
TI  - Living with a crucial decision: a qualitative study of parental narratives three 
      years after the loss of their newborn in the NICU.
PG  - e28633
LID - 10.1371/journal.pone.0028633 [doi]
AB  - BACKGROUND: The importance of involving parents in the end-of-life
      decision-making-process (EOL DMP) for their child in the neonatal intensive care 
      unit (NICU) is recognised by ethical guidelines in numerous countries. However,
      studies exploring parents' opinions on the type of involvement report conflicting
      results. This study sought to explore parents' experience of the EOL DMP for
      their child in the NICU. METHODS: The study used a retrospective longitudinal
      design with a qualitative analysis of parental experience 3 years after the death
      of their child in four NICUs in France. 53 face-to-face interviews and 80
      telephone interviews were conducted with 164 individuals. Semi-structured
      interviews were conducted to explore how parents perceived their role in the
      decision process, what they valued about physicians' attitudes in this situation 
      and whether their long-term emotional well being varied according to their
      perceived role in the EOL DMP. FINDINGS: Qualitative analysis identified four
      types of perceived role in the DMP: shared, medical, informed parental decision, 
      and no decision. Shared DM was the most appreciated by parents. Medical DM was
      experienced as positive only when it was associated with communication. Informed 
      parental DM was associated with feelings of anxiousness and abandonment. The
      physicians' attitudes that were perceived as helpful in the long term were
      explicit sharing of responsibility, clear expression of staff preferences, and
      respectful care and language toward the child. INTERPRETATION: Parents find it
      valuable to express their opinion in the EOL DMP of their child. Nonetheless,
      they do need continuous emotional support and an explicit share of the
      responsibility for the decision. As involvement preferences and associated
      feelings can vary, parents should be able to decide what role they want to play. 
      However, our study suggests that fully autonomous decisions should be misadvised 
      in these types of tragic choices.
FAU - Caeymaex, Laurence
AU  - Caeymaex L
AD  - Centre Hospitalier Intercommunal de Creteil, Newborn Intensive Care Unit,
      Department of Research in Ethics EA 1610 Studies on Science and Techniques,
      Paris-South University, Creteil, France. laurencecmx@yahoo.fr
FAU - Speranza, Mario
AU  - Speranza M
FAU - Vasilescu, Caroline
AU  - Vasilescu C
FAU - Danan, Claude
AU  - Danan C
FAU - Bourrat, Marie-Michele
AU  - Bourrat MM
FAU - Garel, Micheline
AU  - Garel M
FAU - Jousselme, Catherine
AU  - Jousselme C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111214
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adult
MH  - Attitude of Health Personnel
MH  - *Death
MH  - *Decision Making
MH  - Demography
MH  - Emotions
MH  - Female
MH  - France
MH  - Humans
MH  - Infant, Newborn
MH  - *Intensive Care Units, Neonatal
MH  - Interviews as Topic
MH  - Male
MH  - *Narration
MH  - Parents/*psychology
MH  - Professional-Family Relations
MH  - *Qualitative Research
PMC - PMC3237456
EDAT- 2011/12/24 06:00
MHDA- 2012/08/28 06:00
CRDT- 2011/12/24 06:00
PHST- 2011/06/19 00:00 [received]
PHST- 2011/11/11 00:00 [accepted]
PHST- 2011/12/24 06:00 [entrez]
PHST- 2011/12/24 06:00 [pubmed]
PHST- 2012/08/28 06:00 [medline]
AID - 10.1371/journal.pone.0028633 [doi]
AID - PONE-D-11-11369 [pii]
PST - ppublish
SO  - PLoS One. 2011;6(12):e28633. doi: 10.1371/journal.pone.0028633. Epub 2011 Dec 14.


PMID- 22194862
OWN - NLM
STAT- MEDLINE
DCOM- 20120827
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 6
IP  - 12
DP  - 2011
TI  - The integrated HIV-1 provirus in patient sperm chromosome and its transfer into
      the early embryo by fertilization.
PG  - e28586
LID - 10.1371/journal.pone.0028586 [doi]
AB  - Complete understanding of the route of HIV-1 transmission is an important
      prerequisite for curbing the HIV/AIDS pandemic. So far, the known routes of HIV-1
      transmission include sexual contact, needle sharing, puncture, transfusion and
      mother-to-child transmission. Whether HIV can be vertically transmitted from
      human sperm to embryo by fertilization is largely undetermined. Direct research
      on embryo derived from infected human sperm and healthy human ova have been
      difficult because of ethical issues and problems in the collection of ova.
      However, the use of inter-specific in vitro fertilization (IVF) between human
      sperm and hamster ova can avoid both of these problems. Combined with molecular, 
      cytogenetical and immunological techniques such as the preparation of human sperm
      chromosomes, fluorescent in situ hybridization (FISH), and immunofluorescence
      assay (IFA), this study mainly explored whether any integrated HIV provirus were 
      present in the chromosomes of infected patients' sperm, and whether that provirus
      could be transferred into early embryos by fertilization and maintain its
      function of replication and expression. Evidence showed that HIV-1 nucleic acid
      was present in the spermatozoa of HIV/AIDS patients, that HIV-1 provirus is
      present on the patient sperm chromosome, that the integrated provirus could be
      transferred into early embryo chromosomally integrated by fertilization, and that
      it could replicate alongside the embryonic genome and subsequently express its
      protein in the embryo. These findings indicate the possibility of vertical
      transmission of HIV-1 from the sperm genome to the embryonic genome by
      fertilization. This study also offers a platform for the research into this new
      mode of transmission for other viruses, especially sexually transmitted viruses.
FAU - Wang, Dian
AU  - Wang D
AD  - Research Center for Reproductive Medicine, Shantou University Medical College,
      Shantou, China.
FAU - Li, Lian-Bing
AU  - Li LB
FAU - Hou, Zhi-Wei
AU  - Hou ZW
FAU - Kang, Xiang-Jin
AU  - Kang XJ
FAU - Xie, Qing-Dong
AU  - Xie QD
FAU - Yu, Xiao-jun
AU  - Yu XJ
FAU - Ma, Ming-Fu
AU  - Ma MF
FAU - Ma, Bo-Lu
AU  - Ma BL
FAU - Wang, Zheng-Song
AU  - Wang ZS
FAU - Lei, Yong
AU  - Lei Y
FAU - Huang, Tian-Hua
AU  - Huang TH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111214
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (HIV Core Protein p24)
RN  - 0 (gag Gene Products, Human Immunodeficiency Virus)
RN  - 0 (pol Gene Products, Human Immunodeficiency Virus)
SB  - IM
MH  - Animals
MH  - Biotinylation
MH  - Cell Nucleus/virology
MH  - Cricetinae
MH  - Embryo, Mammalian/*virology
MH  - *Fertilization in Vitro
MH  - Fluorescent Antibody Technique
MH  - HIV Core Protein p24/metabolism
MH  - HIV Infections/virology
MH  - HIV-1/*physiology
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Ovum/metabolism
MH  - Proviruses/*physiology
MH  - Sex Chromosomes/*virology
MH  - Spermatozoa/*virology
MH  - Virus Integration/*physiology
MH  - Virus Replication
MH  - gag Gene Products, Human Immunodeficiency Virus/metabolism
MH  - pol Gene Products, Human Immunodeficiency Virus/metabolism
PMC - PMC3237474
EDAT- 2011/12/24 06:00
MHDA- 2012/08/28 06:00
CRDT- 2011/12/24 06:00
PHST- 2011/07/12 00:00 [received]
PHST- 2011/11/10 00:00 [accepted]
PHST- 2011/12/24 06:00 [entrez]
PHST- 2011/12/24 06:00 [pubmed]
PHST- 2012/08/28 06:00 [medline]
AID - 10.1371/journal.pone.0028586 [doi]
AID - PONE-D-11-13295 [pii]
PST - ppublish
SO  - PLoS One. 2011;6(12):e28586. doi: 10.1371/journal.pone.0028586. Epub 2011 Dec 14.


PMID- 22194730
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1664-1078 (Electronic)
IS  - 1664-1078 (Linking)
VI  - 2
DP  - 2011
TI  - Emerging signs of strong reciprocity in human ontogeny.
PG  - 353
LID - 10.3389/fpsyg.2011.00353 [doi]
AB  - Strong reciprocity is considered here as the propensity to sacrifice resources to
      be kind or to punish in response to prior acts, a behavior not simply reducible
      to self-interest and a likely force behind human cooperation and sociality. The
      aim was to capture emerging signs of strong reciprocity in human ontogeny and
      across highly contrasted cultures. Three- and 5-year-old middle class American
      children (N = 162) were tested in a simple, multiple round, three-way sharing
      game involving the child, a generous puppet, and a stingy puppet. At the end of
      the game, the child was offered an opportunity to sacrifice some of her personal 
      gains to punish one of the puppets. By 3 years, American children demonstrate a
      willingness to engage in costly punishment. However, only 5-year-olds show some
      evidence of strong reciprocity by orienting their punishment systematically
      toward the stingy puppet. Further analyses and three additional control
      conditions demonstrate that such propensity is not simply reducible to (a)
      straight imitation, or (b) inequity aversion. To assess the relative universality
      of such development, a group of 5- to 6-year-old children from rural Samoa (N =
      14) were tested and compared to age and gender-matched American children. Samoan 
      children did not manifest the same propensity toward strong reciprocity. The
      results are interpreted as pointing to (1) the developmental emergence of an
      ethical stance between 3 and 5 years of age, and (2) that the expression of such 
      stance by young children could depend on culture.
FAU - Robbins, Erin
AU  - Robbins E
AD  - Department of Psychology, Emory University Atlanta, GA, USA.
FAU - Rochat, Philippe
AU  - Rochat P
LA  - eng
PT  - Journal Article
DEP - 20111219
PL  - Switzerland
TA  - Front Psychol
JT  - Frontiers in psychology
JID - 101550902
PMC - PMC3242362
OTO - NOTNLM
OT  - costly punishment
OT  - cross-cultural psychology
OT  - egalitarianism
OT  - moral reasoning
OT  - sharing
OT  - strong reciprocity
EDAT- 2011/12/24 06:00
MHDA- 2011/12/24 06:01
CRDT- 2011/12/24 06:00
PHST- 2011/08/27 00:00 [received]
PHST- 2011/11/09 00:00 [accepted]
PHST- 2011/12/24 06:00 [entrez]
PHST- 2011/12/24 06:00 [pubmed]
PHST- 2011/12/24 06:01 [medline]
AID - 10.3389/fpsyg.2011.00353 [doi]
PST - epublish
SO  - Front Psychol. 2011 Dec 19;2:353. doi: 10.3389/fpsyg.2011.00353. eCollection
      2011.


PMID- 22194319
OWN - NLM
STAT- MEDLINE
DCOM- 20130527
LR  - 20141120
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 4
DP  - 2013 Apr
TI  - Biodefence and the production of knowledge: rethinking the problem.
PG  - 195-204
LID - 10.1136/medethics-2011-100387 [doi]
AB  - Biodefence, broadly understood as efforts to prevent or mitigate the damage of a 
      bioterrorist attack, raises a number of ethical issues, from the allocation of
      scarce biomedical research and public health funds, to the use of coercion in
      quarantine and other containment measures in the event of an outbreak. In
      response to the US bioterrorist attacks following September 11, significant US
      policy decisions were made to spur scientific enquiry in the name of biodefence. 
      These decisions led to a number of critical institutional changes within the US
      federal government agencies governing scientific research. Subsequent science
      policy discussions have focused largely on 'the dual use problem': how to
      preserve the openness of scientific research while preventing research undertaken
      for the prevention or mitigation of biological threats from third parties. We
      join others in shifting the ethical debate over biodefence away from a simple
      framing of the problem as one of dual use, by demonstrating how a dual use
      framing distorts the debate about bioterrorism and truncates discussion of the
      moral issues. We offer an alternative framing rooted in social epistemology and
      institutional design theory, arguing that the ethical and policy debates
      regarding 'dual use' biomedical research ought to be reframed as a larger
      optimisation problem across a plurality of values including, among others: (1)
      the production of scientific knowledge; (2) the protection of human and animal
      subjects; (3) the promotion and protection of public health (national and
      global); (4) freedom of scientific enquiry; and (5) the constraint of government 
      power.
FAU - Buchanan, Allen
AU  - Buchanan A
AD  - Duke University, Durham, NC, USA. allenb@duke.edu
FAU - Kelley, Maureen C
AU  - Kelley MC
LA  - eng
PT  - Journal Article
DEP - 20111222
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
CIN - J Med Ethics. 2013 Apr;39(4):207-8. PMID: 22613696
CIN - J Med Ethics. 2013 Apr;39(4):205-6. PMID: 23139390
CIN - J Med Ethics. 2013 Apr;39(4):206-7. PMID: 23345570
MH  - *Academies and Institutes/ethics
MH  - *Access to Information
MH  - Advisory Committees
MH  - Animals
MH  - Biomedical Research/*ethics/standards/trends
MH  - Bioterrorism/*prevention & control
MH  - Computer Security/standards
MH  - Ethics, Research
MH  - *Freedom
MH  - Global Health
MH  - *Government Agencies
MH  - Humans
MH  - *Knowledge
MH  - *Public Health
MH  - Public Policy
MH  - *Research Subjects
MH  - Security Measures/*standards/trends
MH  - Social Responsibility
MH  - Social Values
MH  - United States
EDAT- 2011/12/24 06:00
MHDA- 2013/05/29 06:00
CRDT- 2011/12/24 06:00
PHST- 2011/12/24 06:00 [entrez]
PHST- 2011/12/24 06:00 [pubmed]
PHST- 2013/05/29 06:00 [medline]
AID - medethics-2011-100387 [pii]
AID - 10.1136/medethics-2011-100387 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Apr;39(4):195-204. doi: 10.1136/medethics-2011-100387. Epub
      2011 Dec 22.


PMID- 22194277
OWN - NLM
STAT- MEDLINE
DCOM- 20120716
LR  - 20211021
IS  - 1569-9285 (Electronic)
IS  - 1569-9285 (Linking)
VI  - 14
IP  - 3
DP  - 2012 Mar
TI  - Policies of withholding and withdrawal of life-sustaining treatment in critically
      ill patients on cardiac intensive care units in Germany: a national survey.
PG  - 294-9
LID - 10.1093/icvts/ivr119 [doi]
AB  - OBJECTIVE: To determine the decision-making process of withholding and/or
      withdrawal (WH/WD) of life-sustaining treatment in cardiac intensive care units
      (ICUs) in Germany. METHODS: A questionnaire regarding 16 medical and 6 ethical
      questions of WH/WD of life-sustaining treatment was distributed to the clinical
      director, senior ICU physician and head nurses of all German heart surgery
      centres (n = 237 questionnaires). Furthermore, we present a literature survey
      using the key words 'End-of-life care AND withholding/withdrawal of life support 
      therapy AND intensive care unit'. RESULTS: We received replies from 86 of 237
      (36.3%) contacted persons. Concerning medical reasons, cranial computed
      tomography (CCT) with poor prognosis (91.9%), multi-organ failure (70.9%) and
      failure of assist device therapy (69.8%) were the three most frequently cited
      medical reasons for WH/WD life-sustaining treatment. Overall, 32.6% of persons
      answered that ethical aspects influence their decision-making processes. Poor
      expected quality of life (48.8%), the patient's willingness to limit medical care
      (40.7%) and the families' choice (27.9%) were the top three reported ethical
      reasons. There was a significant difference regarding the perception of the three
      involved professional groups concerning the decision-making parameters:
      multi-organ failure (P = 0.018), failure of assist device therapy (P = 0.001),
      cardiac index (P = 0.009), poor expected quality of life (P = 0.009), the
      patient's willingness to limit medical care (P = 0.002), intraoperative course (P
      = 0.054), opinion of family members (P = 0.032) and whether decision-making
      process are done collaboratively (clinical director, 45.7%; ICU physician, 52%;
      and head of nursing staff, 26.9%). Palliation medication in patients after WH/WD 
      of life-support consisted of morphine (92%) and benzodiazepines (88%).
      CONCLUSIONS: This survey is a step towards creating standards of end-of-life care
      in cardiac ICUs, which may contribute to build consensus and avoid conflicts
      among caregivers, patients and families at each step of the decision-making
      process.
FAU - Schimmer, Christoph
AU  - Schimmer C
AD  - Department of Cardiothoracic and Thoracic Vascular Surgery, University Hospital
      Wurzburg, Wurzburg, Germany. schimmer_c@klinik.uni-wuerzburg.de
FAU - Gorski, Armin
AU  - Gorski A
FAU - Ozkur, Mehmet
AU  - Ozkur M
FAU - Sommer, Sebastian-Patrick
AU  - Sommer SP
FAU - Hamouda, Khaled
AU  - Hamouda K
FAU - Hain, Johannes
AU  - Hain J
FAU - Aleksic, Ivan
AU  - Aleksic I
FAU - Leyh, Rainer
AU  - Leyh R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
DEP - 20111222
PL  - England
TA  - Interact Cardiovasc Thorac Surg
JT  - Interactive cardiovascular and thoracic surgery
JID - 101158399
SB  - IM
MH  - Cardiac Surgical Procedures
MH  - *Coronary Care Units
MH  - Critical Illness/psychology/*therapy
MH  - Decision Making/*ethics
MH  - Euthanasia, Passive/*ethics
MH  - Germany
MH  - Humans
MH  - Life Support Care/ethics/*standards
MH  - *Practice Guidelines as Topic
MH  - Retrospective Studies
MH  - Surveys and Questionnaires
MH  - Withholding Treatment/ethics/*standards/statistics & numerical data
PMC - PMC3290372
EDAT- 2011/12/24 06:00
MHDA- 2012/07/17 06:00
CRDT- 2011/12/24 06:00
PHST- 2011/12/24 06:00 [entrez]
PHST- 2011/12/24 06:00 [pubmed]
PHST- 2012/07/17 06:00 [medline]
AID - ivr119 [pii]
AID - 10.1093/icvts/ivr119 [doi]
PST - ppublish
SO  - Interact Cardiovasc Thorac Surg. 2012 Mar;14(3):294-9. doi: 10.1093/icvts/ivr119.
      Epub 2011 Dec 22.


PMID- 22194146
OWN - NLM
STAT- MEDLINE
DCOM- 20120409
LR  - 20111223
IS  - 1532-8457 (Electronic)
IS  - 1043-4542 (Linking)
VI  - 28
IP  - 6
DP  - 2011 Nov-Dec
TI  - The management of the sibling hematopoietic stem cell donor.
PG  - 336-43
LID - 10.1177/1043454211409584 [doi]
AB  - Hematopoietic stem cell transplants are procedures with curative potential for
      patients with diseased, damaged, or absent stem cells. Because a sibling has the 
      best chance of immunocompatibility with one in need of a transplant, siblings are
      the most suitable donors of stem cells. However, when siblings are stem cell
      donors, various ethical issues arise concerning the risks and benefits to the
      pediatric donor. Because of the critical and potential rapid deterioration of the
      recipient's condition, the needs of the sibling donor may be overlooked. This
      potential lack of advocacy for the pediatric sibling donor creates a role for the
      primary care provider to assess the child's physical and psychological ability to
      undergo the donation procedure, examine the ethical issues in choosing to use the
      pediatric sibling as the stem cell donor, prepare the child for the procedure,
      and follow-up with the sibling donor once the procedure is completed.
FAU - Vogel, Rebecca Jill
AU  - Vogel RJ
AD  - Columbia University, New York, NY, USA. rjv2107@columbia.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pediatr Oncol Nurs
JT  - Journal of pediatric oncology nursing : official journal of the Association of
      Pediatric Oncology Nurses
JID - 8917825
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - Middle Aged
MH  - *Siblings
MH  - *Tissue Donors
EDAT- 2011/12/24 06:00
MHDA- 2012/04/10 06:00
CRDT- 2011/12/24 06:00
PHST- 2011/12/24 06:00 [entrez]
PHST- 2011/12/24 06:00 [pubmed]
PHST- 2012/04/10 06:00 [medline]
AID - 28/6/336 [pii]
AID - 10.1177/1043454211409584 [doi]
PST - ppublish
SO  - J Pediatr Oncol Nurs. 2011 Nov-Dec;28(6):336-43. doi: 10.1177/1043454211409584.


PMID- 22194069
OWN - NLM
STAT- MEDLINE
DCOM- 20120427
LR  - 20190201
IS  - 2384-8553 (Electronic)
IS  - 0021-2571 (Linking)
VI  - 47
IP  - 4
DP  - 2011
TI  - Informed consent from cognitively impaired persons participating in research
      trials: comparative law observations.
PG  - 353-62
LID - 10.4415/ANN_11_04_06 [doi]
AB  - This article addresses the ethical requirements to be considered when conducting 
      clinical trials involving human subjects whose mental condition limits their
      ability to understand the information and to express fully autonomous and
      informed consent. It does not address other categories of vulnerable persons,
      such as children, or advanced directives concerning end-of-life care. There are
      many ethical issues entailed in clinical trials involving subjects with mental
      disabilities: how to obtain informed consent, balancing risks and benefits,
      balancing individual benefits with collective scientific and social interests,
      legal representation and many more. This article focuses on the issues
      surrounding the concept of minimal risk and the relationship between informed
      consent and risk. These issues are addressed with particular emphasis on the
      regulations adopted by the European Union and the federal government of the
      United States of America. The conclusion proposes a list of working criteria.
FAU - Petrini, Carlo
AU  - Petrini C
AD  - Unita di Bioetica, Presidenza, Istituto Superiore di Sanita, Via Giano della
      Bella 34, Rome, Italy. carlo.petrini@iss.it
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - Ann Ist Super Sanita
JT  - Annali dell'Istituto superiore di sanita
JID - 7502520
SB  - IM
MH  - Clinical Trials as Topic/*legislation & jurisprudence/*standards
MH  - *Cognition Disorders
MH  - Ethics, Research
MH  - European Union
MH  - Harm Reduction
MH  - Humans
MH  - Informed Consent/*legislation & jurisprudence/*standards
MH  - Italy
MH  - Risk
EDAT- 2011/12/24 06:00
MHDA- 2012/04/28 06:00
CRDT- 2011/12/24 06:00
PHST- 2011/12/24 06:00 [entrez]
PHST- 2011/12/24 06:00 [pubmed]
PHST- 2012/04/28 06:00 [medline]
AID - 10.4415/ANN_11_04_06 [doi]
PST - ppublish
SO  - Ann Ist Super Sanita. 2011;47(4):353-62. doi: 10.4415/ANN_11_04_06.


PMID- 22193738
OWN - NLM
STAT- MEDLINE
DCOM- 20120413
LR  - 20191210
IS  - 1545-7230 (Electronic)
IS  - 1042-9670 (Linking)
VI  - 35
IP  - 6
DP  - 2011 Nov 1
TI  - An ethical approach to life-long learning: implications for global psychiatry.
PG  - 391-6
LID - 10.1176/appi.ap.35.6.391 [doi]
FAU - Song, Suzan Joon
AU  - Song SJ
AD  - Stanford VA/VA Advanced Fellowship Program in Mental Illness Research and
      Treatment, Sierra-Pacific MIRECC, VA Palo Alto Health Care System, Palo Alto, CA,
      USA. suzan.song@post.harvard.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Acad Psychiatry
JT  - Academic psychiatry : the journal of the American Association of Directors of
      Psychiatric Residency Training and the Association for Academic Psychiatry
JID - 8917200
SB  - IM
MH  - Altruism
MH  - Cooperative Behavior
MH  - Cross-Cultural Comparison
MH  - *Developing Countries
MH  - Education, Medical, Continuing/*ethics
MH  - Ethics, Medical/*education
MH  - Humans
MH  - Interdisciplinary Communication
MH  - *International Educational Exchange
MH  - *Internationality
MH  - Programmed Instructions as Topic
MH  - Psychiatry/*education
MH  - Social Responsibility
EDAT- 2011/12/24 06:00
MHDA- 2012/04/14 06:00
CRDT- 2011/12/24 06:00
PHST- 2011/12/24 06:00 [entrez]
PHST- 2011/12/24 06:00 [pubmed]
PHST- 2012/04/14 06:00 [medline]
AID - 10.1176/appi.ap.35.6.391 [doi]
PST - ppublish
SO  - Acad Psychiatry. 2011 Nov 1;35(6):391-6. doi: 10.1176/appi.ap.35.6.391.


PMID- 22192610
OWN - NLM
STAT- MEDLINE
DCOM- 20130410
LR  - 20120926
IS  - 1532-1940 (Electronic)
IS  - 0266-4356 (Linking)
VI  - 50
IP  - 7
DP  - 2012 Oct
TI  - Thyroid surgery.
PG  - 585-91
LID - 10.1016/j.bjoms.2011.11.002 [doi]
LID - S0266-4356(11)00647-4 [pii]
AB  - Diseases of the thyroid are common and surgical treatment is often the preferred 
      option. Thyroid surgery is becoming subspecialised and falls within the
      repertoire of maxillofacial, and head and neck surgeons. Multidisciplinary
      management of most patients with diseases of the thyroid is key to providing the 
      best care particularly for those with malignancies and retrosternal extension. To
      reduce postoperative complications a meticulous search for, and protection of the
      recurrent laryngeal nerve and parathyroid glands, with an incision along the skin
      crease in the lower neck, which can be extended for neck dissection, are
      paramount. Recent advances in thyroid surgery include ultrasound-guided cervical 
      plexus block, use of the Harmonic Scalpel((R)) (Ethicon Endo-Surgery, Inc., USA),
      intraoperative nerve stimulation to monitor the recurrent laryngeal nerve, use of
      TissuePatch 3 (Tissuemed Ltd., Leeds, UK) adhesive sealant, and minimal access
      surgery.
CI  - Copyright (c) 2011 The British Association of Oral and Maxillofacial Surgeons.
      Published by Elsevier Ltd. All rights reserved.
FAU - Cheng, Leo H-H
AU  - Cheng LH
AD  - Oral and Maxillofacial Surgery, St Bartholomew's & The Royal London, United
      Kingdom; Homerton University Hospitals, London, United Kingdom.
      leo.cheng@bartsandthelondon.nhs.uk
FAU - Hutchison, Iain L
AU  - Hutchison IL
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111221
PL  - Scotland
TA  - Br J Oral Maxillofac Surg
JT  - The British journal of oral & maxillofacial surgery
JID - 8405235
SB  - IM
MH  - Humans
MH  - Neck Dissection/instrumentation/*methods
MH  - Parathyroid Glands/*surgery
MH  - Postoperative Complications/prevention & control
MH  - Recurrent Laryngeal Nerve/*surgery
MH  - Thyroid Diseases/*surgery
MH  - Thyroid Neoplasms/surgery
EDAT- 2011/12/24 06:00
MHDA- 2013/04/11 06:00
CRDT- 2011/12/24 06:00
PHST- 2011/03/27 00:00 [received]
PHST- 2011/11/03 00:00 [accepted]
PHST- 2011/12/24 06:00 [entrez]
PHST- 2011/12/24 06:00 [pubmed]
PHST- 2013/04/11 06:00 [medline]
AID - S0266-4356(11)00647-4 [pii]
AID - 10.1016/j.bjoms.2011.11.002 [doi]
PST - ppublish
SO  - Br J Oral Maxillofac Surg. 2012 Oct;50(7):585-91. doi:
      10.1016/j.bjoms.2011.11.002. Epub 2011 Dec 21.


PMID- 22192524
OWN - NLM
STAT- MEDLINE
DCOM- 20120716
LR  - 20131121
IS  - 1096-7206 (Electronic)
IS  - 1096-7192 (Linking)
VI  - 105
IP  - 3
DP  - 2012 Mar
TI  - Long-term betaine therapy in a murine model of cystathionine beta-synthase
      deficient homocystinuria: decreased efficacy over time reveals a significant
      threshold effect between elevated homocysteine and thrombotic risk.
PG  - 395-403
LID - 10.1016/j.ymgme.2011.11.190 [doi]
AB  - Classical homocystinuria (HCU) is caused by deficiency of cystathionine
      beta-synthase and is characterized by connective tissue disturbances, mental
      retardation and cardiovascular disease. Treatment for pyridoxine non-responsive
      HCU typically involves lowering homocysteine levels with a methionine-restricted 
      diet and dietary supplementation with betaine. Compliance with the
      methionine-restricted diet is difficult and often poor. Investigating
      optimization of the efficacy of long-term betaine treatment in isolation from a
      methionine-restricted diet is precluded by ethical considerations regarding
      patient risk. The HO mouse model of HCU developed in our laboratory, exhibits
      constitutive expression of multiple pro-inflammatory cytokines and a
      hypercoagulative phenotype both of which respond to short-term betaine treatment.
      Investigation of the effects of long-term betaine treatment in the absence of
      methionine-restriction in HO HCU mice revealed that the ability of betaine
      treatment to lower homocysteine diminished significantly over time. Plasma
      metabolite analysis indicated that this effect was due at least in part, to
      reduced betaine-homocysteine S-methyltransferase (BHMT) mediated remethylation of
      homocysteine. Western blotting analysis revealed that BHMT protein levels are
      significantly repressed in untreated HCU mice but are significantly induced in
      the presence of betaine treatment. The observed increase in plasma homocysteine
      during prolonged betaine treatment was accompanied by a significant increase in
      the plasma levels of TNF-alpha and IL-1beta and reversion to a hypercoagulative
      phenotype. Our findings are consistent with a relatively sharp threshold effect
      between severely elevated plasma homocysteine and thrombotic risk in HCU and
      indicate that the HO mouse model can serve as a useful tool for both testing
      novel treatment strategies and examining the optimal timing and dosing of betaine
      treatment with a view toward optimizing clinical outcome.
CI  - Copyright A(c) 2011 Elsevier Inc. All rights reserved.
FAU - Maclean, Kenneth N
AU  - Maclean KN
AD  - Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO
      80045-0511, USA. ken.maclean@UCdenver.edu
FAU - Jiang, Hua
AU  - Jiang H
FAU - Greiner, Lori S
AU  - Greiner LS
FAU - Allen, Robert H
AU  - Allen RH
FAU - Stabler, Sally P
AU  - Stabler SP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111202
PL  - United States
TA  - Mol Genet Metab
JT  - Molecular genetics and metabolism
JID - 9805456
RN  - 0 (Interleukin-1beta)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 3SCV180C9W (Betaine)
RN  - AE28F7PNPL (Methionine)
RN  - EC 2.1.1.5 (Betaine-Homocysteine S-Methyltransferase)
RN  - EC 4.2.1.22 (Cystathionine beta-Synthase)
SB  - IM
MH  - Animals
MH  - Betaine/administration & dosage/pharmacology/*therapeutic use
MH  - Betaine-Homocysteine S-Methyltransferase/*biosynthesis/metabolism
MH  - Blood Coagulation
MH  - Cystathionine beta-Synthase/deficiency/*metabolism
MH  - Diet
MH  - Dietary Supplements
MH  - Disease Models, Animal
MH  - Homocysteine/*blood/metabolism
MH  - Homocystinuria/blood/*drug therapy/genetics
MH  - Interleukin-1beta/blood
MH  - Male
MH  - Methionine
MH  - Methylation
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Thrombosis/*etiology
MH  - Tumor Necrosis Factor-alpha/blood
EDAT- 2011/12/24 06:00
MHDA- 2012/07/17 06:00
CRDT- 2011/12/24 06:00
PHST- 2011/11/15 00:00 [received]
PHST- 2011/11/16 00:00 [accepted]
PHST- 2011/12/24 06:00 [entrez]
PHST- 2011/12/24 06:00 [pubmed]
PHST- 2012/07/17 06:00 [medline]
AID - S1096-7192(11)00607-X [pii]
AID - 10.1016/j.ymgme.2011.11.190 [doi]
PST - ppublish
SO  - Mol Genet Metab. 2012 Mar;105(3):395-403. doi: 10.1016/j.ymgme.2011.11.190. Epub 
      2011 Dec 2.


PMID- 22191312
OWN - NLM
STAT- MEDLINE
DCOM- 20120117
LR  - 20190918
IS  - 0042-8450 (Print)
IS  - 0042-8450 (Linking)
VI  - 68
IP  - 11
DP  - 2011 Nov
TI  - [Early inflammatory response following elective abdominal aortic aneurysm repair:
      a comparison between endovascular procedure and conventional, open surgery].
PG  - 948-55
AB  - BACKGROUND/AIM: Abdominal aorta aneurysm (AAA) represents a pathological
      enlargment of infrarenal portion of aorta for over 50% of its lumen. The only
      treatment of AAA is a surgical reconstruction of the affected segment. Until the 
      late XX century, surgical reconstruction implied explicit, open repair (OR) of
      AAA, which was accompanied by a significant morbidity and mortality of the
      treated patients. Development of endovascular repair of (EVAR) AAA, especially in
      the last decade, offered another possibility of surgical reconstruction of AAA.
      The preliminary results of world studies show that complications of such a
      procedure, as well as morbidity and mortality of patients, are significantly
      lower than with OR of AAA. The aim of this paper was to present results of
      comparative clinical prospective study of early inflammatory response after
      reconstruction of AAA be tween endovascular and open, conventional surgical
      technique. METHODS: A comparative clinical prospective study included 39
      patients, electively operated on for AAA within the period of December 2008 -
      February 2010, divided into two groups. The group I counted 21 (54%) of the
      patients, 58-87 years old (mean 74.3 years), who had been submited to EVAR by the
      use of excluder stent graft. The group II consisted of 18 (46%) of the patients, 
      49-82 (mean 66.8) years, operated on using OR technique. All of the treated
      patients in both groups had AAA larger than 50 mm. The study did not include
      patients who have been treated as urgent cases, due to the rupture or with
      simptomatic AAA. Clinical, biochemical and inflamatory parameters in early
      postoperative period were analyzed, in direct postoperative course (number of
      leucocytes, thrombocytes, serum circulating levels of cytokine--interleukine
      (IL)-2, IL-4, IL-6 and IL-10). Parameters were monitored on the zero, first,
      second, third and seventh postoperative days. The study was approved by the
      Ethics Commitee of the Military Medical Academy. RESULTS: The study showed a
      statistically significantly shorter time of treatment in the EVAR group (average 
      90 min) compared to the OR group (average 136 min). Also, there was a
      statistically significantly less blood loss in the patients operated on by the
      use of EVAR surgery (average 60 mL) as compared to the patients treated with OR
      techinique (average 495 mL), as well as a shorter postoperative hospitalization
      of patients in the EVAR group (average 4 days) compared to the OR group (average 
      8 days). The OR group was detected with a statistically significant increase of
      leucocytes and statistically significant fall of the number of thrombocytes in
      comparison with the EVAR group in all the investigated terms. A significant
      concentration rise of IL-2 in the OR group and concentration rise of IL-6 in the 
      EVAR group was shown 24 hours after the procedure, whereas on the second
      postoperative day there was detected a significant fall of IL-6 in the EVAR
      group. IL-4 concentration in the OR group was significantly higher as of the
      third postoperative day in comparison to the EVAR group. There was no significant
      difference in IL-10 concentration between the groups. CONCLUSION: The EVAR
      techinique is a safer and less invasive and less traumatic procedure for patients
      than the OR of AAA. Following the EVAR, there are less inflammatory reactions in 
      the early postoperative period as compared to the OR and therefore less
      possibility of the development of systemic inflammatory respons syndrome in
      patients treated.
FAU - Marjanovic, Ivan
AU  - Marjanovic I
AD  - Vojnomedicinska akademija, Klinika za vaskulamu hirurgiju, Beograd, Srbija.
      sofijaivan@gmail.com
FAU - Jevtic, Miodrag
AU  - Jevtic M
FAU - Misovic, Sidor
AU  - Misovic S
FAU - Vojvodic, Danilo
AU  - Vojvodic D
FAU - Zoranovic, Uros
AU  - Zoranovic U
FAU - Rusovic, Sinisa
AU  - Rusovic S
FAU - Sarac, Momir
AU  - Sarac M
FAU - Stanojevic, Ivan
AU  - Stanojevic I
LA  - srp
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
PL  - Serbia
TA  - Vojnosanit Pregl
JT  - Vojnosanitetski pregled
JID - 21530700R
RN  - 0 (Inflammation Mediators)
RN  - 0 (Interleukins)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aortic Aneurysm, Abdominal/blood/*surgery
MH  - *Endovascular Procedures
MH  - Female
MH  - Humans
MH  - Inflammation Mediators/*blood
MH  - Interleukins/*blood
MH  - Male
MH  - Middle Aged
EDAT- 2011/12/24 06:00
MHDA- 2012/01/18 06:00
CRDT- 2011/12/24 06:00
PHST- 2011/12/24 06:00 [entrez]
PHST- 2011/12/24 06:00 [pubmed]
PHST- 2012/01/18 06:00 [medline]
AID - 10.2298/vsp1111948m [doi]
PST - ppublish
SO  - Vojnosanit Pregl. 2011 Nov;68(11):948-55. doi: 10.2298/vsp1111948m.


PMID- 22191152
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20111223
IS  - 1320-3185 (Print)
IS  - 1320-3185 (Linking)
VI  - 19
IP  - 5
DP  - 2011 Nov
TI  - Nursing ethics and informed consent.
PG  - 29
FAU - Johnstone, Megan-Jane
AU  - Johnstone MJ
AD  - School of Nursing at Deakin University, Victoria.
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Aust Nurs J
JT  - Australian nursing journal (July 1993)
JID - 9317904
MH  - Australia
MH  - *Ethics, Nursing
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Moral Obligations
EDAT- 2011/12/24 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/12/24 06:00
PHST- 2011/12/24 06:00 [entrez]
PHST- 2011/12/24 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
PST - ppublish
SO  - Aust Nurs J. 2011 Nov;19(5):29.


PMID- 22190958
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1687-9597 (Electronic)
IS  - 1687-9597 (Linking)
VI  - 2012
DP  - 2012
TI  - Ethical issues in pharmacologic research in women undergoing pregnancy
      termination: a systemic review and survey of researchers.
PG  - 724591
LID - 10.1155/2012/724591 [doi]
AB  - Objective. To evaluate the ethics of performing research in the field of
      maternal-fetal medicine involving women undergoing pregnancy termination.
      Methods. We identified published pharmacological studies performed during
      elective pregnancy termination. In addition, a questionnaire was administered to 
      investigate whether this research would be acceptable to professionals performing
      research in the field of maternal-fetal pharmacology. Results. The majority of
      participants believe that this form of research is necessary to furthering our
      understanding of drug use in pregnancy. Twenty studies were identified in women
      undergoing a pregnancy termination where exogenous drug was administered and drug
      measurement conducted during an abortion. The majority of studies were completed 
      by international groups and not in North America or Western Europe. Conclusions. 
      While a majority of respondents to the survey felt that, although research in
      women undergoing a pregnancy termination is ethically acceptable, 40% stated that
      it is not likely to be approved by institutional review boards of most North
      American medical institutions.
FAU - Gedeon, Christelle
AU  - Gedeon C
AD  - Motherisk Program, Division of Clinical Pharmacology and Toxicology, The Hospital
      for Sick Children, Toronto, ON, Canada M5G 1X8.
FAU - Nava-Ocampo, Alejandro A
AU  - Nava-Ocampo AA
FAU - Koren, Gideon
AU  - Koren G
LA  - eng
PT  - Journal Article
DEP - 20111130
PL  - United States
TA  - Obstet Gynecol Int
JT  - Obstetrics and gynecology international
JID - 101517078
PMC - PMC3236419
EDAT- 2011/12/23 06:00
MHDA- 2011/12/23 06:01
CRDT- 2011/12/23 06:00
PHST- 2011/08/12 00:00 [received]
PHST- 2011/09/28 00:00 [revised]
PHST- 2011/10/04 00:00 [accepted]
PHST- 2011/12/23 06:00 [entrez]
PHST- 2011/12/23 06:00 [pubmed]
PHST- 2011/12/23 06:01 [medline]
AID - 10.1155/2012/724591 [doi]
PST - ppublish
SO  - Obstet Gynecol Int. 2012;2012:724591. doi: 10.1155/2012/724591. Epub 2011 Nov 30.


PMID- 22190889
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120830
LR  - 20211021
IS  - 1524-5012 (Print)
IS  - 1524-5012 (Linking)
VI  - 11
IP  - 4
DP  - 2011 Winter
TI  - Bioethics consultations and resources.
PG  - 357-9
AB  - Making difficult healthcare decisions is often helped by consultation with a
      bioethics committee. This article reviews the main bioethics principles, when it 
      is appropriate and how to call a bioethics consult, ethical concerns, and members
      of the consult team. Bioethics resources are included.
FAU - Thomas, Jennie
AU  - Thomas J
AD  - Pastoral Care, Ochsner Clinic Foundation, New Orleans, LA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ochsner J
JT  - The Ochsner journal
JID - 101125795
PMC - PMC3241071
OTO - NOTNLM
OT  - Bioethics
OT  - bioethics consult
OT  - ethics
OT  - ethics consult
EDAT- 2011/12/23 06:00
MHDA- 2011/12/23 06:01
CRDT- 2011/12/23 06:00
PHST- 2011/12/23 06:00 [entrez]
PHST- 2011/12/23 06:00 [pubmed]
PHST- 2011/12/23 06:01 [medline]
PST - ppublish
SO  - Ochsner J. 2011 Winter;11(4):357-9.


PMID- 22190883
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120830
LR  - 20211021
IS  - 1524-5012 (Print)
IS  - 1524-5012 (Linking)
VI  - 11
IP  - 4
DP  - 2011 Winter
TI  - Legal Considerations in End-of-Life Decisionmaking in Louisiana.
PG  - 330-3
AB  - End-of-life directives are among the most difficult decisions that a patient or a
      patient's family makes because of the many moral, ethical, legal, and practical
      considerations. This article addresses the basic legal framework in Louisiana for
      end-of-life directives. Although Louisiana law provides a framework for
      addressing end-of-life issues, the law does not dictate outcomes or decisions.
      The law is often the refuge of last resort, providing unsatisfactory results.
      End-of-life care decisions are generally most productive when they are based on
      discussions between patients, their families, and their care team regarding the
      patient's wishes.
FAU - Koppel, Ann
AU  - Koppel A
AD  - Office of Legal Affairs and Risk Management, Ochsner Clinic Foundation, New
      Orleans, LA.
FAU - Sullivan, Shelley M
AU  - Sullivan SM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ochsner J
JT  - The Ochsner journal
JID - 101125795
PMC - PMC3241065
OTO - NOTNLM
OT  - Do not resuscitate
OT  - Louisiana
OT  - end of life
OT  - law
EDAT- 2011/12/23 06:00
MHDA- 2011/12/23 06:01
CRDT- 2011/12/23 06:00
PHST- 2011/12/23 06:00 [entrez]
PHST- 2011/12/23 06:00 [pubmed]
PHST- 2011/12/23 06:01 [medline]
PST - ppublish
SO  - Ochsner J. 2011 Winter;11(4):330-3.


PMID- 22190882
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120830
LR  - 20220321
IS  - 1524-5012 (Print)
IS  - 1524-5012 (Linking)
VI  - 11
IP  - 4
DP  - 2011 Winter
TI  - The Nurse Advocate in End-of-Life Care.
PG  - 325-9
AB  - End-of-life nursing encompasses many aspects of care: pain and symptom
      management, culturally sensitive practices, assisting patients and their families
      through the death and dying process, and ethical decisionmaking. Advocacy has
      been identified as a key core competency for the professional nurse, yet the
      literature reveals relevant barriers to acquiring this skill. Challenges exist,
      such as limitations in nursing school curricula on the death and dying process,
      particularly in multicultural settings; differing policies and practices in
      healthcare systems; and various interpretations of end-of-life legal language.
      Patricia Benner's conceptual model of advocacy behaviors in end-of-life nursing
      provides the framework in which nurses can become effective patient advocates.
      Developing active listening and effective communication skills can enhance the
      nurse-patient trust relationship and create a healing environment.
FAU - Hebert, Kathy
AU  - Hebert K
FAU - Moore, Harold
AU  - Moore H
FAU - Rooney, Joan
AU  - Rooney J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ochsner J
JT  - The Ochsner journal
JID - 101125795
PMC - PMC3241064
OTO - NOTNLM
OT  - Advance directives
OT  - advocacy
OT  - comfort measures
OT  - dignity
OT  - end-of-life care
OT  - stages of grief
EDAT- 2011/12/23 06:00
MHDA- 2011/12/23 06:01
CRDT- 2011/12/23 06:00
PHST- 2011/12/23 06:00 [entrez]
PHST- 2011/12/23 06:00 [pubmed]
PHST- 2011/12/23 06:01 [medline]
PST - ppublish
SO  - Ochsner J. 2011 Winter;11(4):325-9.


PMID- 22190599
OWN - NLM
STAT- MEDLINE
DCOM- 20120529
LR  - 20120130
IS  - 1744-5019 (Electronic)
IS  - 0360-5310 (Linking)
VI  - 37
IP  - 1
DP  - 2012 Feb
TI  - Advance directives and personal identity: what is the problem?
PG  - 60-73
LID - 10.1093/jmp/jhr055 [doi]
AB  - The personal identity problem expresses the worry that due to disrupted
      psychological continuity, one person's advance directive could be used to
      determine the care of a different person. Even ethicists, who strongly question
      the possibility of the scenario depicted by the proponents of the personal
      identity problem, often consider it to be a very potent objection to the use of
      advance directives. Aiming to question this assumption, I, in this paper, discuss
      the personal identity problem's relevance to the moral force of advance
      directives. By putting the personal identity argument in relation to two
      different normative frameworks, I aim to show that whether or not the personal
      identity problem is relevant to the moral force of advance directives, and
      further, in what way it is relevant, depends entirely on what normative reasons
      we have for respecting advance directives in the first place.
FAU - Furberg, Elisabeth
AU  - Furberg E
AD  - Department of Philosophy, Stockholm University, SE-106 91, Stockholm, Sweden.
      lisa.furberg@philosophy.su.se
LA  - eng
PT  - Journal Article
DEP - 20111220
PL  - United States
TA  - J Med Philos
JT  - The Journal of medicine and philosophy
JID - 7610512
SB  - IM
MH  - Advance Directive Adherence/ethics
MH  - Advance Directives/*ethics
MH  - Alzheimer Disease/psychology
MH  - Decision Making/*ethics
MH  - Human Rights
MH  - Humans
MH  - *Individuality
MH  - Mental Competency/psychology
MH  - *Self Concept
EDAT- 2011/12/23 06:00
MHDA- 2012/05/30 06:00
CRDT- 2011/12/23 06:00
PHST- 2011/12/23 06:00 [entrez]
PHST- 2011/12/23 06:00 [pubmed]
PHST- 2012/05/30 06:00 [medline]
AID - jhr055 [pii]
AID - 10.1093/jmp/jhr055 [doi]
PST - ppublish
SO  - J Med Philos. 2012 Feb;37(1):60-73. doi: 10.1093/jmp/jhr055. Epub 2011 Dec 20.


PMID- 22190412
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120507
LR  - 20120118
IS  - 1521-3773 (Electronic)
IS  - 1433-7851 (Linking)
VI  - 51
IP  - 4
DP  - 2012 Jan 23
TI  - Citations and ethics.
PG  - 828-30
LID - 10.1002/anie.201107554 [doi]
FAU - Reedijk, Jan
AU  - Reedijk J
LA  - eng
PT  - Editorial
DEP - 20111221
PL  - Germany
TA  - Angew Chem Int Ed Engl
JT  - Angewandte Chemie (International ed. in English)
JID - 0370543
EDAT- 2011/12/23 06:00
MHDA- 2011/12/23 06:01
CRDT- 2011/12/23 06:00
PHST- 2011/12/23 06:00 [entrez]
PHST- 2011/12/23 06:00 [pubmed]
PHST- 2011/12/23 06:01 [medline]
AID - 10.1002/anie.201107554 [doi]
PST - ppublish
SO  - Angew Chem Int Ed Engl. 2012 Jan 23;51(4):828-30. doi: 10.1002/anie.201107554.
      Epub 2011 Dec 21.


PMID- 22189599
OWN - NLM
STAT- MEDLINE
DCOM- 20130205
LR  - 20211021
IS  - 1573-2665 (Electronic)
IS  - 0141-8955 (Linking)
VI  - 35
IP  - 4
DP  - 2012 Jul
TI  - Newborn screening for lysosomal storage diseases: an ethical and policy analysis.
PG  - 627-34
LID - 10.1007/s10545-011-9435-0 [doi]
AB  - The traditional focus of newborn screening (NBS) is testing infants for medical
      conditions like phenylketonuria (PKU) that may cause significant morbidity or
      mortality unless treatment is initiated early. Although the Wilson and Jungner
      criteria were not designed specifically for NBS, the public health screening
      criteria have been used, with some modifications, to justify what conditions are 
      included in a universal NBS panel. These criteria are being challenged by
      platform technologies like tandem mass spectrometry (MS/MS) that allow for the
      identification of numerous conditions on a single sample because they identify
      many conditions and variants simultaneously, some of which meet and others which 
      fail to meet the criteria. In this manuscript, I evaluate three lysosomal storage
      diseases included in this multiplex screening test-Pompe disease, Fabry disease, 
      and Krabbe disease. I show that they fail to meet some of the critical Wilson and
      Jungner criteria and thus are not ready for inclusion in universal NBS panels.
      Rather, screening for these conditions should only be performed in the research
      context with institutional review board approval and parental permission.
FAU - Ross, Lainie Friedman
AU  - Ross LF
AD  - University of Chicago, 5841 S Maryland Ave, MC 6082, Chicago, IL 60637, USA.
      Lross@uchicago.edu
LA  - eng
PT  - Journal Article
DEP - 20111222
PL  - United States
TA  - J Inherit Metab Dis
JT  - Journal of inherited metabolic disease
JID - 7910918
SB  - IM
MH  - Humans
MH  - Infant, Newborn
MH  - Lysosomal Storage Diseases/*diagnosis
MH  - Neonatal Screening/*ethics/*methods
MH  - Parents
MH  - Policy Making
MH  - Public Health/*ethics/*methods
MH  - Tandem Mass Spectrometry/methods
EDAT- 2011/12/23 06:00
MHDA- 2013/02/06 06:00
CRDT- 2011/12/23 06:00
PHST- 2011/10/25 00:00 [received]
PHST- 2011/12/01 00:00 [accepted]
PHST- 2011/11/26 00:00 [revised]
PHST- 2011/12/23 06:00 [entrez]
PHST- 2011/12/23 06:00 [pubmed]
PHST- 2013/02/06 06:00 [medline]
AID - 10.1007/s10545-011-9435-0 [doi]
PST - ppublish
SO  - J Inherit Metab Dis. 2012 Jul;35(4):627-34. doi: 10.1007/s10545-011-9435-0. Epub 
      2011 Dec 22.


PMID- 22189547
OWN - NLM
STAT- MEDLINE
DCOM- 20120412
LR  - 20211021
IS  - 1614-0575 (Electronic)
IS  - 1613-6071 (Linking)
VI  - 8
IP  - 2
DP  - 2011 Summer
TI  - Modeling chick to assess diabetes pathogenesis and treatment.
PG  - 245-53
LID - 10.1900/RDS.2011.8.245 [doi]
AB  - Animal models have been used extensively in diabetes research. Studies on animal 
      models have contributed to the discovery and purification of insulin, development
      of new therapeutic approaches, and progress in fundamental and clinical research.
      However, conventional rodent and large animal mammalian models face ethical,
      practical, or technical limitations. Therefore, it would be beneficial developing
      an alternative model for diabetes research which would overcome these
      limitations. Amongst other vertebrates, birds are phylogenically closer to
      mammals, and amongst birds, the chick has been used as one of the favored models 
      in developmental biology, toxicology, cancer research, immunology, and drug
      testing. Chicken eggs are readily available, have a short incubation period and
      easily accessible embryos. Based on these inimitable advantages, the present
      review article aims to discuss the suitability of the chick as a model system to 
      study specific aspects of diabetes. The review focuses on the application of i)
      chick pancreatic islets for screening of antidiabetic agents and for islet
      banking, (ii) shell-less chick embryo culture as a model to study
      hyperglycemia-induced malformations observed in mammalian embryos, and (iii)
      chick chorioallantoic membrane (CAM) to examine glucose-induced endothelial
      damage leading to inhibition of angiogenesis.
CI  - Copyright (c) by Lab & Life Press/SBDR
FAU - Datar, Savita P
AU  - Datar SP
AD  - Department of Zoology, Sir Parshurambhau College, Pune 411030, India.
FAU - Bhonde, Ramesh R
AU  - Bhonde RR
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110810
PL  - Singapore
TA  - Rev Diabet Stud
JT  - The review of diabetic studies : RDS
JID - 101227575
RN  - 0 (Hypoglycemic Agents)
SB  - IM
MH  - Animals
MH  - Chick Embryo
MH  - Chorioallantoic Membrane/pathology
MH  - Diabetes Mellitus/*drug therapy/*pathology
MH  - *Disease Models, Animal
MH  - Hypoglycemic Agents/*pharmacology
MH  - Islets of Langerhans/drug effects/pathology
MH  - Neovascularization, Pathologic/pathology
PMC - PMC3280009
EDAT- 2011/12/23 06:00
MHDA- 2012/04/13 06:00
CRDT- 2011/12/23 06:00
PHST- 2011/12/23 06:00 [entrez]
PHST- 2011/12/23 06:00 [pubmed]
PHST- 2012/04/13 06:00 [medline]
AID - 10.1900/RDS.2011.8.245 [doi]
PST - ppublish
SO  - Rev Diabet Stud. 2011 Summer;8(2):245-53. doi: 10.1900/RDS.2011.8.245. Epub 2011 
      Aug 10.


PMID- 22189173
OWN - NLM
STAT- MEDLINE
DCOM- 20120221
LR  - 20111222
IS  - 1741-8453 (Print)
IS  - 1741-8453 (Linking)
VI  - 6
IP  - 2-4
DP  - 2011
TI  - A risk management model for securing virtual healthcare communities.
PG  - 95-116
LID - 10.1504/IJEH.2011.044344 [doi]
AB  - Virtual healthcare communities aim to bring together healthcare professionals and
      patients, improve the quality of healthcare services and assist healthcare
      professionals and researchers in their everyday activities. In a secure and
      reliable environment, patients share their medical data with doctors, expect
      confidentiality and demand reliable medical consultation. Apart from a concrete
      policy framework, several ethical, legal and technical issues must be considered 
      in order to build a trustful community. This research emphasises on security
      issues, which can arise inside a virtual healthcare community and relate to the
      communication and storage of data. It capitalises on a standardised risk
      management methodology and a prototype architecture for healthcare community
      portals and justifies a security model that allows the identification, estimation
      and evaluation of potential security risks for the community. A hypothetical
      virtual healthcare community is employed in order to portray security risks and
      the solutions that the security model provides.
FAU - Chryssanthou, Anargyros
AU  - Chryssanthou A
AD  - Hellenic Data Protection Authority, Auditors Department, Ampelokipoi, Greece.
      achrysanthou@dpa.gr
FAU - Varlamis, Iraklis
AU  - Varlamis I
FAU - Latsiou, Charikleia
AU  - Latsiou C
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Int J Electron Healthc
JT  - International journal of electronic healthcare
JID - 101227192
SB  - IM
MH  - Caregivers
MH  - *Computer Security
MH  - Confidentiality
MH  - Health Personnel
MH  - Health Services Accessibility/*organization & administration
MH  - Health Services Research
MH  - Humans
MH  - Information Systems/*organization & administration
MH  - *Internet
MH  - Medical Records Systems, Computerized/organization & administration
MH  - Patients
MH  - Risk Management/*organization & administration
MH  - *User-Computer Interface
EDAT- 2011/12/23 06:00
MHDA- 2012/02/22 06:00
CRDT- 2011/12/23 06:00
PHST- 2011/12/23 06:00 [entrez]
PHST- 2011/12/23 06:00 [pubmed]
PHST- 2012/02/22 06:00 [medline]
AID - FM436887544X4223 [pii]
AID - 10.1504/IJEH.2011.044344 [doi]
PST - ppublish
SO  - Int J Electron Healthc. 2011;6(2-4):95-116. doi: 10.1504/IJEH.2011.044344.


PMID- 22189087
OWN - NLM
STAT- MEDLINE
DCOM- 20120703
LR  - 20120207
IS  - 1695-9531 (Electronic)
IS  - 1695-4033 (Linking)
VI  - 76
IP  - 2
DP  - 2012 Feb
TI  - [Idiopathic short stature and treatment with biosynthetic growth hormone:
      clinical and ethical reflections on an arbitrary diagnosis].
PG  - 53-7
LID - 10.1016/j.anpedi.2011.10.009 [doi]
FAU - Soriano-Guillen, L
AU  - Soriano-Guillen L
FAU - Argente, J
AU  - Argente J
LA  - spa
PT  - Editorial
TT  - Talla baja idiopatica y tratamiento con hormona de crecimiento biosintetica:
      reflexiones clinicas y eticas ante un diagnostico arbitrario.
DEP - 20111219
PL  - Spain
TA  - An Pediatr (Barc)
JT  - Anales de pediatria (Barcelona, Spain : 2003)
JID - 101162596
RN  - 12629-01-5 (Human Growth Hormone)
SB  - IM
MH  - Bioethical Issues
MH  - Body Height
MH  - Child
MH  - Dwarfism/*diagnosis/*drug therapy
MH  - Human Growth Hormone/*therapeutic use
MH  - Humans
EDAT- 2011/12/23 06:00
MHDA- 2012/07/04 06:00
CRDT- 2011/12/23 06:00
PHST- 2011/10/17 00:00 [received]
PHST- 2011/10/18 00:00 [accepted]
PHST- 2011/12/23 06:00 [entrez]
PHST- 2011/12/23 06:00 [pubmed]
PHST- 2012/07/04 06:00 [medline]
AID - S1695-4033(11)00543-1 [pii]
AID - 10.1016/j.anpedi.2011.10.009 [doi]
PST - ppublish
SO  - An Pediatr (Barc). 2012 Feb;76(2):53-7. doi: 10.1016/j.anpedi.2011.10.009. Epub
      2011 Dec 19.


PMID- 22188646
OWN - NLM
STAT- MEDLINE
DCOM- 20120321
LR  - 20211021
IS  - 1476-069X (Electronic)
IS  - 1476-069X (Linking)
VI  - 10
DP  - 2011 Dec 21
TI  - Data sharing: not as simple as it seems.
PG  - 107
LID - 10.1186/1476-069X-10-107 [doi]
AB  - In recent years there has been a major change on the part of funders,
      particularly in North America, so that data sharing is now considered to be the
      norm rather than the exception. We believe that data sharing is a good idea.
      However, we also believe that it is inappropriate to prescribe exactly when or
      how researchers should preserve and share data, since these issues are highly
      specific to each study, the nature of the data collected, who is requesting it,
      and what they intend to do with it. The level of ethical concern will vary
      according to the nature of the information, and the way in which it is collected 
      - analyses of anonymised hospital admission records may carry a quite different
      ethical burden than analyses of potentially identifiable health information
      collected directly from the study participants. It is striking that most
      discussions about data sharing focus almost exclusively on issues of ownership
      (by the researchers or the funders) and efficiency (on the part of the funders). 
      There is usually little discussion of the ethical issues involved in data
      sharing, and its implications for the study participants. Obtaining prior
      informed consent from the participants does not solve this problem, unless the
      informed consent process makes it completely clear what is being proposed, in
      which case most study participants would not agree. Thus, the undoubted benefits 
      of data sharing does not remove the obligations and responsibilities that the
      original investigators hold for the people they invited to participate in the
      study.
FAU - Pearce, Neil
AU  - Pearce N
AD  - Faculty of Epidemiology and Population Health, London School of Hygiene and
      Tropical Medicine, UK. neil.pearce@lshtm.ac.uk
FAU - Smith, Allan H
AU  - Smith AH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111221
PL  - England
TA  - Environ Health
JT  - Environmental health : a global access science source
JID - 101147645
SB  - IM
MH  - *Access to Information
MH  - Biomedical Research/standards
MH  - Humans
MH  - Information Dissemination/*ethics
MH  - Informed Consent
MH  - New Zealand
MH  - *Publishing/standards
MH  - Research Design/standards
MH  - Research Personnel/psychology
MH  - Tonga
PMC - PMC3260112
EDAT- 2011/12/23 06:00
MHDA- 2012/03/22 06:00
CRDT- 2011/12/23 06:00
PHST- 2011/11/24 00:00 [received]
PHST- 2011/12/21 00:00 [accepted]
PHST- 2011/12/23 06:00 [entrez]
PHST- 2011/12/23 06:00 [pubmed]
PHST- 2012/03/22 06:00 [medline]
AID - 1476-069X-10-107 [pii]
AID - 10.1186/1476-069X-10-107 [doi]
PST - epublish
SO  - Environ Health. 2011 Dec 21;10:107. doi: 10.1186/1476-069X-10-107.


PMID- 22188386
OWN - NLM
STAT- MEDLINE
DCOM- 20120801
LR  - 20220316
IS  - 1479-828X (Electronic)
IS  - 0004-8666 (Linking)
VI  - 52
IP  - 2
DP  - 2012 Apr
TI  - Ethical issues: the multi-centre low-risk ethics/governance review process and
      AMOSS.
PG  - 195-203
LID - 10.1111/j.1479-828X.2011.01390.x [doi]
AB  - BACKGROUND: The Australasian Maternity Outcomes Surveillance System (AMOSS)
      conducts surveillance and research of rare and serious conditions in pregnancy.
      This multi-centre population health study is considered low risk with minimal
      ethical impact. OBJECTIVE: To describe the ethics/governance review pathway
      undertaken by AMOSS. METHOD: Prospective, descriptive study during 2009-2011 of
      the governance/ethical review processes required to gain approval for Australian 
      and New Zealand (ANZ) maternity units with more than 50 births per year (n = 303)
      to participate in AMOSS. RESULTS: Review processes ranged from a single
      application for 24 NZ sites, a single application for eligible hospitals in two
      Australian states, full Health Research Ethics Committee (HREC) applications for 
      individual hospitals, through simple letters of support. As of September 2011, 46
      full/expedited ethics applications, 131 site governance applications and 136
      letters of support requests were made over 33 months, involving an estimated 3261
      hours by AMOSS staff/investigators, and an associated resource burden by
      participating sites, to obtain approval to receive nonidentifiable data from 291 
      hospitals. CONCLUSION: The AMOSS research system provides an important resource
      to enhance knowledge of conditions that cause rare and serious maternal
      morbidity. Yet the highly variable ethical approval processes required to
      implement this study have been excessively repetitive and burdensome. This
      process jeopardises timely, efficient research project implementation, without
      corresponding benefits to research participants. The resource burden to establish
      research governance for AMOSS confirms the urgent need for the Harmonisation of
      Multi-centre Ethical Review (HoMER) to further streamline ethics/governance
      review processes for multi-centre research.
CI  - (c) 2011 The Authors. Australian and New Zealand Journal of Obstetrics and
      Gynaecology (c) 2011 The Royal Australian and New Zealand College of
      Obstetricians and Gynaecologists.
FAU - Vaughan, Geraldine
AU  - Vaughan G
AD  - Australasian Maternity Outcomes Surveillance System, Perinatal and Reproductive
      Epidemiology Research Unit, School of Women's and Children's Health, Faculty of
      Medicine, University of New South Wales, Sydney, New South Wales, Australia.
      geri@unsw.edu.au
FAU - Pollock, Wendy
AU  - Pollock W
FAU - Peek, Michael J
AU  - Peek MJ
FAU - Knight, Marian
AU  - Knight M
FAU - Ellwood, David
AU  - Ellwood D
FAU - Homer, Caroline S
AU  - Homer CS
FAU - Pulver, Lisa Jackson
AU  - Pulver LJ
FAU - McLintock, Claire
AU  - McLintock C
FAU - Ho, Maria T
AU  - Ho MT
FAU - Sullivan, Elizabeth A
AU  - Sullivan EA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111220
PL  - Australia
TA  - Aust N Z J Obstet Gynaecol
JT  - The Australian & New Zealand journal of obstetrics & gynaecology
JID - 0001027
SB  - IM
MH  - Adult
MH  - Australia
MH  - Ethical Review
MH  - Ethics Committees, Research
MH  - Ethics, Research
MH  - Female
MH  - Health Care Surveys/*ethics
MH  - Hospitals, Maternity/*ethics
MH  - Humans
MH  - Maternal Mortality
MH  - Medical Audit/*ethics
MH  - Multicenter Studies as Topic/ethics
MH  - New Zealand
MH  - Pregnancy
MH  - Prospective Studies
MH  - Risk
EDAT- 2011/12/23 06:00
MHDA- 2012/08/02 06:00
CRDT- 2011/12/23 06:00
PHST- 2011/12/23 06:00 [entrez]
PHST- 2011/12/23 06:00 [pubmed]
PHST- 2012/08/02 06:00 [medline]
AID - 10.1111/j.1479-828X.2011.01390.x [doi]
PST - ppublish
SO  - Aust N Z J Obstet Gynaecol. 2012 Apr;52(2):195-203. doi:
      10.1111/j.1479-828X.2011.01390.x. Epub 2011 Dec 20.


PMID- 22188159
OWN - NLM
STAT- MEDLINE
DCOM- 20130510
LR  - 20220331
IS  - 1365-2060 (Electronic)
IS  - 0785-3890 (Linking)
VI  - 45
IP  - 2
DP  - 2013 Mar
TI  - Human papillomavirus (HPV) vaccine policy and evidence-based medicine: are they
      at odds?
PG  - 182-93
LID - 10.3109/07853890.2011.645353 [doi]
AB  - All drugs are associated with some risks of adverse reactions. Because vaccines
      represent a special category of drugs, generally given to healthy individuals,
      uncertain benefits mean that only a small level of risk for adverse reactions is 
      acceptable. Furthermore, medical ethics demand that vaccination should be carried
      out with the participant's full and informed consent. This necessitates an
      objective disclosure of the known or foreseeable vaccination benefits and risks. 
      The way in which HPV vaccines are often promoted to women indicates that such
      disclosure is not always given from the basis of the best available knowledge.
      For example, while the world's leading medical authorities state that HPV
      vaccines are an important cervical cancer prevention tool, clinical trials show
      no evidence that HPV vaccination can protect against cervical cancer. Similarly, 
      contrary to claims that cervical cancer is the second most common cancer in women
      worldwide, existing data show that this only applies to developing countries. In 
      the Western world cervical cancer is a rare disease with mortality rates that are
      several times lower than the rate of reported serious adverse reactions
      (including deaths) from HPV vaccination. Future vaccination policies should
      adhere more rigorously to evidence-based medicine and ethical guidelines for
      informed consent.
FAU - Tomljenovic, Lucija
AU  - Tomljenovic L
AD  - Neural Dynamics Research Group, Department of Ophthalmology and Visual Sciences, 
      University of British Columbia, 828 W. 10th Ave, Vancouver, BC, V5Z 1L8, Canada. 
      lucijat77@gmail.com
FAU - Shaw, Christopher A
AU  - Shaw CA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20111222
PL  - England
TA  - Ann Med
JT  - Annals of medicine
JID - 8906388
RN  - 0 (Papillomavirus Vaccines)
SB  - IM
CIN - Ann Med. 2012 Jun;44(4):404. PMID: 22462602
MH  - Developing Countries
MH  - Evidence-Based Medicine/*methods
MH  - Female
MH  - Humans
MH  - Papillomaviridae/*immunology
MH  - Papillomavirus Infections/*prevention & control
MH  - Papillomavirus Vaccines/*adverse effects/therapeutic use
MH  - *Practice Guidelines as Topic
MH  - Uterine Cervical Neoplasms/*prevention & control
EDAT- 2011/12/23 06:00
MHDA- 2013/05/11 06:00
CRDT- 2011/12/23 06:00
PHST- 2011/12/23 06:00 [entrez]
PHST- 2011/12/23 06:00 [pubmed]
PHST- 2013/05/11 06:00 [medline]
AID - 10.3109/07853890.2011.645353 [doi]
PST - ppublish
SO  - Ann Med. 2013 Mar;45(2):182-93. doi: 10.3109/07853890.2011.645353. Epub 2011 Dec 
      22.


PMID- 22187919
OWN - NLM
STAT- MEDLINE
DCOM- 20120330
LR  - 20111222
IS  - 1592-7830 (Print)
IS  - 1592-7830 (Linking)
VI  - 33
IP  - 2 Suppl
DP  - 2011 Apr-Jun
TI  - [The health and welfare of migrant workers as a factor in business
      competitiveness].
PG  - 26-8
AB  - The role of the enterprises in tackling the immigration theme was significant in 
      the last few years, though within a context of tensions, necessity of flexible
      approaches, and swaying feelings. However, the world of the entrepreneurs has
      certainly contributed to the promotion of quality of life and to the process of
      integration, through a few actions, such as education, the use of mediators for
      culture, cooperation with projects aimed at family conjunctions, regularizations,
      code of ethics. The acknowledgement that the immigrant workers is more prone to
      acquire health and safety culture is a step forward, as well as the co-existence 
      of cultures is per se a positive factor toward behavioral changes. An industrial 
      policy favoring work for itself, equity and merit, while creating moments of
      encounter, certainly facilitates good organization and integration, and
      delineates pathways for responsibility for immigrant workers as well. The
      occupational plant physician can proactively play a fundamental role for safety
      and health promotion for immigrant workers, considering the special relationship 
      based on trust and the moments of encounter within the workplace, clear occasion 
      "to treat every patient with the same care and diligence, regardless of
      ethnicity, religion, nationality, social condition", as the Hyppocrates oath
      states.
FAU - Moltrasio, A
AU  - Moltrasio A
AD  - Icro Coatings S.p.a., Chignolo d'Isola (BG), Italy. andrea.moltrasio@icro.it
LA  - ita
PT  - English Abstract
PT  - Journal Article
TT  - La tutela della salute e del benessere dei lavoratori immigrati come fattore di
      competitivita aziendale.
PL  - Italy
TA  - G Ital Med Lav Ergon
JT  - Giornale italiano di medicina del lavoro ed ergonomia
JID - 9712708
SB  - IM
MH  - *Commerce
MH  - *Competitive Behavior
MH  - Cultural Characteristics
MH  - *Emigrants and Immigrants
MH  - *Health Promotion/ethics/organization & administration
MH  - *Health Status
MH  - Humans
MH  - Italy
MH  - *Occupational Medicine/ethics
MH  - Physician's Role
MH  - Quality of Life
MH  - Safety
MH  - Social Welfare
MH  - *Transients and Migrants
MH  - Workplace
EDAT- 2011/12/23 06:00
MHDA- 2012/03/31 06:00
CRDT- 2011/12/23 06:00
PHST- 2011/12/23 06:00 [entrez]
PHST- 2011/12/23 06:00 [pubmed]
PHST- 2012/03/31 06:00 [medline]
PST - ppublish
SO  - G Ital Med Lav Ergon. 2011 Apr-Jun;33(2 Suppl):26-8.


PMID- 22187917
OWN - NLM
STAT- MEDLINE
DCOM- 20120330
LR  - 20111222
IS  - 1592-7830 (Print)
IS  - 1592-7830 (Linking)
VI  - 33
IP  - 2 Suppl
DP  - 2011 Apr-Jun
TI  - [Occupational health and immigration: skills, perspectives and areas of
      intervention].
PG  - 16-21
AB  - The occupational physician (OP) has nowadays to face health and safety of migrant
      workers on new ethical, scientific, epidemiologic and legislative basis.
      Objective of our contribution is to describe area of interventions and
      perspectives in good medical practices for OP when dealing with migrant workers. 
      Risk assessment should focus on differences of immigrants versus natives as
      regards exposures and effects, quality of and access to health services,
      organizational issues. Health surveillance should take into account cultural,
      educational, religious, life style differences, as well as susceptibility; time
      must be dedicated by the OP to search and evaluate such differences. Counselling,
      health promotion and case management are part of good medical practice. The
      professional role of the OP is depicted, trying to identify weaknesses and
      strengths, as well as priorities for intervention especially in applied research.
      In conclusion, migrant workers may suffer from occupational health inequalities. 
      By means of good medical practices in risk assessment, health surveillance,
      fitness for work and health promotion, OP can proactively improve migrant
      workers' health and guarantee same levels of protection and prevention in
      workplaces as for the natives.
FAU - Porru, S
AU  - Porru S
AD  - Dipartimento di Medicina Sperimentale ed Applicata, Sezione di Medicina del
      Lavoro ed Igiene Industriale, Universita degli Studi di Brescia, Italy.
      porru@med.unibs.it
FAU - Arici, C
AU  - Arici C
LA  - ita
PT  - English Abstract
PT  - Journal Article
TT  - Medicina del lavoro ed immigrazione: competenze, aree d'intervento e prospettive.
PL  - Italy
TA  - G Ital Med Lav Ergon
JT  - Giornale italiano di medicina del lavoro ed ergonomia
JID - 9712708
SB  - IM
MH  - Emigrants and Immigrants/*statistics & numerical data
MH  - *Emigration and Immigration
MH  - Health Promotion
MH  - Health Services/*standards
MH  - Humans
MH  - Italy/epidemiology
MH  - Occupational Diseases/epidemiology/*prevention & control
MH  - *Occupational Health
MH  - *Physician's Role
MH  - Population Surveillance
MH  - Risk Assessment
MH  - *Workplace
EDAT- 2011/12/23 06:00
MHDA- 2012/03/31 06:00
CRDT- 2011/12/23 06:00
PHST- 2011/12/23 06:00 [entrez]
PHST- 2011/12/23 06:00 [pubmed]
PHST- 2012/03/31 06:00 [medline]
PST - ppublish
SO  - G Ital Med Lav Ergon. 2011 Apr-Jun;33(2 Suppl):16-21.


PMID- 22187596
OWN - NLM
STAT- MEDLINE
DCOM- 20120514
LR  - 20220408
IS  - 1937-8688 (Electronic)
VI  - 10
DP  - 2011
TI  - Controlling Sickle Cell Disease in Ghana--ethics and options.
PG  - 14
AB  - Sickle Cell Disease (SCD) is a significant public health burden in Ghana. Recent 
      studies indicate that 2% of Ghanaian newborns are affected by SCD; one in three
      Ghanaians has the hemoglobin S and/or C gene. As a means of controlling the
      disease, some authorities have recommended prenatal diagnosis (PND) and selective
      abortion. In the current era, SCD has a good prognosis and fairly reasonable
      quality of life. Advances in bone marrow transplantation have shown the disease
      is curable in selected patients. PND and selective abortion therefore raises a
      myriad of ethical dilemmas which are considered in this review. In the light of
      the demonstration of improved prognosis in recent times, PND and selective
      abortion appears to be applying capital punishment to the unborn child for
      "crimes" only the parents can be responsible for. In this review, we recommend
      control of SCD on three levels--preconception genetic testing and strategic
      reproductive choices, PND and education for carrier parents, and holistic
      management of persons with SCD. We emphasize the critical importance of
      self-management, especially self-awareness, in assuring a good quality of life
      for persons with SCD. We believe such an approach is cost-effective, and
      consistent with sound ethical principles and good conscience.
FAU - Kyerewaa Edwin, Ama
AU  - Kyerewaa Edwin A
AD  - Ethics Unit, Medical Directorate, Korle Bu Teaching Hospital, Accra, Ghana.
FAU - Edwin, Frank
AU  - Edwin F
FAU - Etwire, Victor
AU  - Etwire V
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111003
PL  - Uganda
TA  - Pan Afr Med J
JT  - The Pan African medical journal
JID - 101517926
SB  - IM
MH  - Abortion, Eugenic/*ethics
MH  - Anemia, Sickle Cell/*prevention & control
MH  - Ghana
MH  - Humans
PMC - PMC3282939
EDAT- 2011/12/22 06:00
MHDA- 2012/05/15 06:00
CRDT- 2011/12/22 06:00
PHST- 2011/06/13 00:00 [received]
PHST- 2011/09/27 00:00 [accepted]
PHST- 2011/12/22 06:00 [entrez]
PHST- 2011/12/22 06:00 [pubmed]
PHST- 2012/05/15 06:00 [medline]
AID - 10.4314/pamj.v10i0.72223 [doi]
PST - ppublish
SO  - Pan Afr Med J. 2011;10:14. doi: 10.4314/pamj.v10i0.72223. Epub 2011 Oct 3.


PMID- 22187588
OWN - NLM
STAT- MEDLINE
DCOM- 20120514
LR  - 20211021
IS  - 1937-8688 (Electronic)
VI  - 10
DP  - 2011
TI  - Ethical quandaries in spiritual healing and herbal medicine: a critical analysis 
      of the morality of traditional medicine advertising in southern African urban
      societies.
PG  - 6
AB  - This paper critically examines the morality of advertising by practitioners in
      spiritual healing and herbal medicine heretofore referred to as traditional
      medicine, in southern African urban societies. While the subject of traditional
      medicine has been heavily contested in medical studies in the last few decades,
      the monumental studies on the subject have emphasised the place of traditional
      medicine in basic health services. Insignificant attention has been devoted to
      examine the ethical problems associated with traditional medicine advertising.
      Critical look at the worthiness of some advertising strategies used by
      practitioners in traditional medicine in launching their products and services on
      market thus has been largely ignored. Yet, though advertising is key to helping
      traditional medicine practitioners' products and services known by prospective
      customers, this research registers a number of morally negative effects that seem
      to outweigh the merits that the activity brings to prospective customers. The
      paper adopts southern African urban societies, and in particular Mozambique,
      South Africa and Zimbabwe as particular references. The choice of the trio is not
      accidental, but based on the fact that these countries have in the last few
      decades been flooded with traditional medicine practitioners/traditional healers 
      from within the continent and from abroad. Most of these practitioners use
      immoral advertising strategies in communicating to the public the products and
      services they offer. It is against this background that this paper examines the
      morality of advertising strategies deployed by practitioners in launching their
      products and services. To examine the moral worthiness of the advertising
      strategies used by traditional medical practitioners, I used qualitative analysis
      of street adverts as well as electronic and print media. From the results
      obtained through thematic content analysis, the paper concludes that most of the 
      practitioners in traditional medicine lack both business and medical ethics. That
      said, the paper urges practitioners to seriously consider the morality of their
      adverts as in most cases they (adverts) do more harm than good. Further to that, 
      the piece recommends the governments of the affected countries to put in place
      stringent measures to address this mounting problem.
FAU - Munyaradzi, Mawere
AU  - Munyaradzi M
AD  - Department of Social Anthropology, University of Cape Town, South Africa,
      Universidade Pedagogica, Mozambique.
LA  - eng
PT  - Journal Article
DEP - 20110921
PL  - Uganda
TA  - Pan Afr Med J
JT  - The Pan African medical journal
JID - 101517926
SB  - IM
MH  - Advertising/*ethics
MH  - Africa, Southern
MH  - Humans
MH  - *Medicine, Traditional
MH  - Phytotherapy/*ethics
MH  - Spiritual Therapies/*ethics
PMC - PMC3282931
EDAT- 2011/12/22 06:00
MHDA- 2012/05/15 06:00
CRDT- 2011/12/22 06:00
PHST- 2011/07/27 00:00 [received]
PHST- 2011/09/02 00:00 [accepted]
PHST- 2011/12/22 06:00 [entrez]
PHST- 2011/12/22 06:00 [pubmed]
PHST- 2012/05/15 06:00 [medline]
AID - 10.4314/pamj.v10i0.72212 [doi]
PST - ppublish
SO  - Pan Afr Med J. 2011;10:6. doi: 10.4314/pamj.v10i0.72212. Epub 2011 Sep 21.


PMID- 22187410
OWN - NLM
STAT- MEDLINE
DCOM- 20120801
LR  - 20151119
IS  - 1438-8782 (Electronic)
IS  - 0172-4614 (Linking)
VI  - 32 Suppl 2
DP  - 2011 Dec
TI  - Prenatal counseling--implications of the cultural background of pregnant women on
      information processing, emotional response and acceptance.
PG  - E100-7
LID - 10.1055/s-0031-1281665 [doi]
AB  - PURPOSE: Providing information about prenatal diagnosis (PND) that leads to an
      informed decision is ethically and psychologically challenging, especially in an 
      intercultural context. The aim was to investigate cultural differences in
      information processing, test interpretation, evaluation of an established
      information leaflet, emotional response during screening and acceptance of PND.
      MATERIALS AND METHODS: This prospective study compared 30 pregnant Turkish
      immigrants with 30 women from Switzerland and countries within the European Union
      (EU). They completed a questionnaire prior to (T1) and after risk assessment
      between 11-14 weeks (T2) and after receiving the results (T3). The questionnaire 
      focused on the perception of, experiences with and knowledge about the risk
      assessment and included the hospital anxiety and depression scale (HADS). chi(2) 
      tests were used for dichotomous variables and Student's t-tests for scores on
      perception, experience, knowledge, depression and anxiety. Groups were compared
      over time by 2-factorial ANOVA. RESULTS: Regarding the 6 questions on knowledge, 
      the rate of correct answers was between 32.2% and 62.5% at T1 and 35.1% and 75.0%
      at T2. The Turkish women's knowledge level was significantly lower. They rated
      the information leaflet as less helpful and found the counseling significantly
      more unsettling. The acceptance of PND was higher in Turkish women. CONCLUSION:
      Considering the information and knowledge deficits, informed consent was not
      given in every case, especially in Turkish women. Nevertheless, the acceptance of
      PND was good. Further studies will have to focus on counseling strategies that
      take into account the specific needs and expectations of pregnant women with
      different cultural backgrounds.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Tschudin, S
AU  - Tschudin S
AD  - University Hospital Basel, Basel, Switzerland. stschudin@uhbs.ch
FAU - Huang, D
AU  - Huang D
FAU - Mor-Gultekin, H
AU  - Mor-Gultekin H
FAU - Alder, J
AU  - Alder J
FAU - Bitzer, J
AU  - Bitzer J
FAU - Tercanli, S
AU  - Tercanli S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20111220
PL  - Germany
TA  - Ultraschall Med
JT  - Ultraschall in der Medizin (Stuttgart, Germany : 1980)
JID - 8303585
SB  - IM
MH  - *Adaptation, Psychological
MH  - Adult
MH  - Anxiety/ethnology/psychology
MH  - *Counseling
MH  - *Cross-Cultural Comparison
MH  - Depression/ethnology/psychology
MH  - Emigrants and Immigrants/*psychology
MH  - *Emotions
MH  - Europe/ethnology
MH  - Female
MH  - Genetic Counseling/*psychology
MH  - Health Knowledge, Attitudes, Practice/ethnology
MH  - Humans
MH  - Informed Consent/psychology
MH  - Multilingualism
MH  - Patient Acceptance of Health Care/*ethnology/*psychology
MH  - *Patient Education as Topic
MH  - Pregnancy/*ethnology/*psychology
MH  - Pregnancy Trimester, Second
MH  - Prenatal Care/*psychology
MH  - Prenatal Diagnosis/*psychology
MH  - Prospective Studies
MH  - Risk Assessment
MH  - Socioeconomic Factors
MH  - Surveys and Questionnaires
MH  - Switzerland
MH  - Turkey/ethnology
MH  - Ultrasonography, Prenatal/*psychology
EDAT- 2011/12/22 06:00
MHDA- 2012/08/02 06:00
CRDT- 2011/12/22 06:00
PHST- 2011/12/22 06:00 [entrez]
PHST- 2011/12/22 06:00 [pubmed]
PHST- 2012/08/02 06:00 [medline]
AID - 10.1055/s-0031-1281665 [doi]
PST - ppublish
SO  - Ultraschall Med. 2011 Dec;32 Suppl 2:E100-7. doi: 10.1055/s-0031-1281665. Epub
      2011 Dec 20.


PMID- 22187356
OWN - NLM
STAT- MEDLINE
DCOM- 20120606
LR  - 20211021
IS  - 1386-9620 (Print)
IS  - 1386-9620 (Linking)
VI  - 15
IP  - 2
DP  - 2012 Jun
TI  - Presenting Germany's drug pricing rule as a cost-per-QALY rule.
PG  - 103-7
LID - 10.1007/s10729-011-9186-3 [doi]
AB  - In Germany, the Institute for Quality and Efficiency in Health Care (IQWiG) makes
      recommendations for ceiling prices of drugs based on an evaluation of the
      relationship between costs and effectiveness. To set ceiling prices, IQWiG uses
      the following decision rule: the incremental cost-effectiveness ratio of a new
      drug compared with the next effective intervention should not be higher than that
      of the next effective intervention compared to its comparator. The purpose of
      this paper is to show that IQWiG's decision rule can be presented as a
      cost-per-QALY rule by using equity-weighted QALYs. This transformation shows
      where both rules share commonalities. Furthermore, it makes the underlying
      ethical implications of IQWiG's decision rule transparent and open to debate.
FAU - Gandjour, Afschin
AU  - Gandjour A
AD  - Frankfurt School of Finance & Management, Frankfurt, Germany. a.gandjour@fs.de
LA  - eng
PT  - Journal Article
DEP - 20111221
PL  - Netherlands
TA  - Health Care Manag Sci
JT  - Health care management science
JID - 9815649
RN  - 0 (Prescription Drugs)
SB  - IM
MH  - Cost-Benefit Analysis
MH  - Costs and Cost Analysis/*methods
MH  - Decision Support Techniques
MH  - Drug Costs/legislation & jurisprudence/standards
MH  - Drug Industry/economics/legislation & jurisprudence/standards
MH  - Fees, Pharmaceutical/legislation & jurisprudence/standards
MH  - Germany
MH  - Humans
MH  - Prescription Drugs/*economics/standards
MH  - Quality of Health Care/legislation & jurisprudence/standards/statistics &
      numerical data
MH  - *Quality-Adjusted Life Years
EDAT- 2011/12/22 06:00
MHDA- 2012/06/07 06:00
CRDT- 2011/12/22 06:00
PHST- 2011/06/26 00:00 [received]
PHST- 2011/11/02 00:00 [accepted]
PHST- 2011/12/22 06:00 [entrez]
PHST- 2011/12/22 06:00 [pubmed]
PHST- 2012/06/07 06:00 [medline]
AID - 10.1007/s10729-011-9186-3 [doi]
PST - ppublish
SO  - Health Care Manag Sci. 2012 Jun;15(2):103-7. doi: 10.1007/s10729-011-9186-3. Epub
      2011 Dec 21.


PMID- 22187136
OWN - NLM
STAT- MEDLINE
DCOM- 20120820
LR  - 20220330
IS  - 1573-9686 (Electronic)
IS  - 0090-6964 (Linking)
VI  - 40
IP  - 5
DP  - 2012 May
TI  - Effects of age on mechanical properties of dorsiflexor and plantarflexor muscles.
PG  - 1088-101
LID - 10.1007/s10439-011-0481-4 [doi]
AB  - Redundancy in the human muscular system makes it challenging to assess
      age-related changes in muscle mechanical properties in vivo, as ethical
      considerations prohibit direct muscle force measurement. We overcame this by
      using a hybrid approach that combined magnetic resonance and ultrasound imaging, 
      dynamometer measurements, muscle modeling, and numerical optimization to obtain
      subject-specific estimates of the mechanical properties of tibialis anterior,
      gastrocnemius, and soleus muscles from young and older adults. We hypothesized
      that older subjects would have lower maximal isometric forces, slower contractile
      and stiffer elastic characteristics, and that subject-specific muscle properties 
      would give more accurate joint torque predictions compared to generic properties.
      Unknown muscle model parameters were obtained by minimizing the difference
      between simulated and actual subject torque-time histories under both isometric
      and isovelocity conditions. The resulting subject-specific models showed age- and
      gender-related differences, with older adults displaying reduced maximal
      isometric forces, slower force-velocity and altered force-length properties and
      stiffer elasticity. Tibialis anterior was least affected by aging.
      Subject-specific models gave good predictions of experimental concentric
      torque-time histories (10-14% error), but were less accurate for eccentric
      conditions. With generic muscle properties prediction errors were about twice as 
      large. For maximum predictive power, musculoskeletal models should be tailored to
      individual subjects.
FAU - Hasson, Christopher J
AU  - Hasson CJ
AD  - Biomechanics Laboratory, Department of Kinesiology, University of Massachusetts
      Amherst, Amherst, MA, USA. cjhasson@neu.edu
FAU - Caldwell, Graham E
AU  - Caldwell GE
LA  - eng
GR  - R03AG026281/AG/NIA NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20111221
PL  - United States
TA  - Ann Biomed Eng
JT  - Annals of biomedical engineering
JID - 0361512
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aging/*physiology
MH  - Female
MH  - Humans
MH  - Isometric Contraction/*physiology
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - *Models, Biological
MH  - Muscle Strength/*physiology
MH  - Muscle, Skeletal/diagnostic imaging/*physiology
MH  - Radiography
MH  - Ultrasonography
EDAT- 2011/12/22 06:00
MHDA- 2012/08/21 06:00
CRDT- 2011/12/22 06:00
PHST- 2011/08/04 00:00 [received]
PHST- 2011/11/28 00:00 [accepted]
PHST- 2011/12/22 06:00 [entrez]
PHST- 2011/12/22 06:00 [pubmed]
PHST- 2012/08/21 06:00 [medline]
AID - 10.1007/s10439-011-0481-4 [doi]
PST - ppublish
SO  - Ann Biomed Eng. 2012 May;40(5):1088-101. doi: 10.1007/s10439-011-0481-4. Epub
      2011 Dec 21.


PMID- 22186830
OWN - NLM
STAT- MEDLINE
DCOM- 20130104
LR  - 20161125
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 5
DP  - 2012 May
TI  - Proceduralisation, choice and parental reflections on decisions to accept newborn
      bloodspot screening.
PG  - 299-303
LID - 10.1136/medethics-2011-100040 [doi]
AB  - Newborn screening is the programme through which newborn babies are screened for 
      a variety of conditions shortly after birth. Programmes such as this are
      individually oriented but resemble traditional public health programmes because
      they are targeted at large groups of the population and they are offered as
      preventive interventions to a population considered healthy. As such, an ethical 
      tension exists between the goals of promoting the high uptake of supposedly
      'effective' population-oriented programmes and the goal of promoting genuinely
      informed decision-making. There is, however, a lack of understanding with regard 
      to how parents experience the tension between promoting uptake and facilitating
      informed choice. This paper addresses this issue, and data are presented to show 
      how aspects of the timing, presentation of information and procedural
      routinisation of newborn screening serves to impact on the decisions made by
      parents.
FAU - Nicholls, Stuart G
AU  - Nicholls SG
AD  - Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, 
      K1H 8M5, Canada. snicholl@uottawa.ca
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111220
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Canada
MH  - *Choice Behavior
MH  - Decision Making
MH  - Europe
MH  - Humans
MH  - Infant, Newborn
MH  - Information Dissemination/methods
MH  - *Informed Consent
MH  - Narration
MH  - *Neonatal Screening
MH  - *Parents
MH  - *Patient Acceptance of Health Care
MH  - *Personal Autonomy
MH  - *Social Perception
MH  - Time Factors
MH  - United Kingdom
MH  - United States
EDAT- 2011/12/22 06:00
MHDA- 2013/01/05 06:00
CRDT- 2011/12/22 06:00
PHST- 2011/12/22 06:00 [entrez]
PHST- 2011/12/22 06:00 [pubmed]
PHST- 2013/01/05 06:00 [medline]
AID - medethics-2011-100040 [pii]
AID - 10.1136/medethics-2011-100040 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 May;38(5):299-303. doi: 10.1136/medethics-2011-100040. Epub
      2011 Dec 20.


PMID- 22186767
OWN - NLM
STAT- MEDLINE
DCOM- 20130124
LR  - 20211021
IS  - 1434-4726 (Electronic)
IS  - 0937-4477 (Linking)
VI  - 269
IP  - 10
DP  - 2012 Oct
TI  - The effect of resveratrol on the prevention of cisplatin ototoxicity.
PG  - 2185-8
LID - 10.1007/s00405-011-1883-5 [doi]
AB  - One of the most important adverse effects of cisplatin, a chemotherapeutic agent 
      which is widely used in the treatment of cancer patients, is hearing loss. This
      has primarily been associated with the loss of inner ear hairy and spiral
      ganglion cells due to oxidative stress. Resveratrol is known to be an antioxidant
      agent, which has the theoretical potential of preventing cisplatin-related
      ototoxicity. This experimental study was approved by Animal Ethics Committee of
      Inonu University (2008-20) and supported by Inonu University Scientific Research 
      Projects Support Fund (2009-17). Thirty-four 3-month-old Wistar albino female
      rats weighing 210-270 g were used in the study. The animals were allocated into
      four groups: in cisplatin group (Group A), a single dose of 12 mg/kg cisplatin
      was administered intraperitoneally to 10 rats; in cisplatin + resveratrol group
      (Group B), a single dose of 12 mg/kg cisplatin and 10 mg/kg resveratrol were
      administered intraperitoneally for 5 days to 10 rats; in resveratrol group (Group
      C), 10 mg/kg resveratrol was administered intraperitoneally for 5 days to seven
      rats and in control group (Group D), resveratrol solvent (5% alcohol-95%
      physiological saline) was administered intraperitoneally for 5 days to seven
      rats. Resveratrol administration has begun 1 day before cisplatin administration 
      in the group treated with cisplatin and resveratrol combination. Distortion
      product otoacoustic emission (DPOAE) (Grason Stadler, Madison, USA) measurements 
      were performed in the same ear of all rats (right ear) under general anesthesia
      at baseline, 1st and 5th days after drug administration. Statistically
      significant distortion product amplitude reductions were found in the cisplatin
      group at 1,418, 2,003, 3,363, 5,660, 8,003 and 9,515 Hz frequencies. Whereas in
      the cisplatin + resveratrol group, statistically significant difference was found
      between 1st and 5th day measurements only at 3,996 Hz frequency. No significant
      differences were noted between the measurements either in the resveratrol or in
      the control groups. According to these results, cisplatin-related ototoxicity has
      been greatly prevented by resveratrol use.
FAU - Erdem, T
AU  - Erdem T
AD  - Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, Inonu
      University, Malatya, Turkey.
FAU - Bayindir, Tuba
AU  - Bayindir T
FAU - Filiz, A
AU  - Filiz A
FAU - Iraz, M
AU  - Iraz M
FAU - Selimoglu, E
AU  - Selimoglu E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111221
PL  - Germany
TA  - Eur Arch Otorhinolaryngol
JT  - European archives of oto-rhino-laryngology : official journal of the European
      Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the
      German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JID - 9002937
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Stilbenes)
RN  - Q20Q21Q62J (Cisplatin)
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/*adverse effects
MH  - Antioxidants/*therapeutic use
MH  - Cisplatin/*adverse effects
MH  - Evoked Potentials, Auditory, Brain Stem/drug effects
MH  - Female
MH  - Hearing Loss, Sensorineural/prevention & control
MH  - Otoacoustic Emissions, Spontaneous/*drug effects
MH  - Oxidative Stress
MH  - Rats
MH  - Rats, Wistar
MH  - Resveratrol
MH  - Stilbenes/*therapeutic use
EDAT- 2011/12/22 06:00
MHDA- 2013/01/25 06:00
CRDT- 2011/12/22 06:00
PHST- 2011/08/25 00:00 [received]
PHST- 2011/12/09 00:00 [accepted]
PHST- 2011/12/22 06:00 [entrez]
PHST- 2011/12/22 06:00 [pubmed]
PHST- 2013/01/25 06:00 [medline]
AID - 10.1007/s00405-011-1883-5 [doi]
PST - ppublish
SO  - Eur Arch Otorhinolaryngol. 2012 Oct;269(10):2185-8. doi:
      10.1007/s00405-011-1883-5. Epub 2011 Dec 21.


PMID- 22186764
OWN - NLM
STAT- MEDLINE
DCOM- 20120330
LR  - 20211021
IS  - 2150-5608 (Electronic)
IS  - 2150-5594 (Linking)
VI  - 2
IP  - 6
DP  - 2011 Nov-Dec
TI  - Drosophila and Galleria insect model hosts: new tools for the study of fungal
      virulence, pharmacology and immunology.
PG  - 521-7
LID - 10.4161/viru.2.6.18520 [doi]
AB  - Over recent years we have witnessed the emergence of several non-vertebrate
      mini-hosts as alternative pathosystems for the study of fungal disease. These
      heterologous organisms have unique advantages, as they are economical, ethically 
      expedient, and facile to use. Hence, they are amenable to high-throughput
      screening studies of fungal genomes for identification of novel virulence genes
      and of chemical libraries for discovery of new antifungal compounds. In addition,
      because they have evolutionarily conserved immunity they offer the opportunity to
      better understand innate immune responses against medically important fungi. In
      this review, we discuss how the insects Drosophila melanogaster and Galleria
      mellonella can be employed for the study of various facets of host-fungal
      interactions as complementary hosts to conventional vertebrate animal models.
FAU - Lionakis, Michail S
AU  - Lionakis MS
AD  - Clinical Mycology Unit, Laboratory of Molecular Immunology, National Institute of
      Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD,
      USA. lionakism@mail.nih.gov
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Virulence
JT  - Virulence
JID - 101531386
RN  - 0 (Antifungal Agents)
SB  - IM
MH  - Animals
MH  - Antifungal Agents/pharmacology
MH  - *Disease Models, Animal
MH  - *Drosophila/drug effects/immunology
MH  - Fungi/drug effects/genetics/metabolism/*pathogenicity
MH  - Humans
MH  - *Moths/drug effects/immunology
MH  - Mycoses/drug therapy/*immunology/*microbiology
PMC - PMC3260546
EDAT- 2011/12/22 06:00
MHDA- 2012/03/31 06:00
CRDT- 2011/12/22 06:00
PHST- 2011/12/22 06:00 [entrez]
PHST- 2011/12/22 06:00 [pubmed]
PHST- 2012/03/31 06:00 [medline]
AID - 18520 [pii]
AID - 10.4161/viru.2.6.18520 [doi]
PST - ppublish
SO  - Virulence. 2011 Nov-Dec;2(6):521-7. doi: 10.4161/viru.2.6.18520.


PMID- 22186417
OWN - NLM
STAT- MEDLINE
DCOM- 20120305
LR  - 20211021
IS  - 1945-7170 (Electronic)
IS  - 0013-7227 (Linking)
VI  - 153
IP  - 1
DP  - 2012 Jan
TI  - A novel antiinflammatory role for the short-chain fatty acids in human labor.
PG  - 395-403
LID - 10.1210/en.2011-1457 [doi]
AB  - Human parturition is an inflammatory process that can be activated prematurely by
      pathological stimuli. This study investigated the expression of G protein-coupled
      receptors GPR43 and GPR41 receptors in human uteroplacental tissues and the role 
      of short-chain fatty acids (SCFA) in modulating inflammatory pathways in fetal
      membranes. Expression of GPR43 and GPR41 was investigated in uteroplacental
      tissues collected from women delivering at term or preterm after ethical approval
      and patient informed consent. The effect of SCFA on expression of inflammatory
      genes was assessed in amnion explants after culture with a mimetic of infection
      (lipopolysaccharide, LPS). Sodium propionate effect on LPS-induced neutrophil
      chemotaxis was evaluated by transwell assay. GPR43 and GPR41 mRNA expression was 
      higher in myometrium and fetal membranes collected from women after the onset of 
      labor. GPR43 protein expression localized to immune cells and vascular
      endothelium in the myometrium and epithelium of fetal membranes. Treatment with
      LPS significantly increased mRNA expression of GPR43 and inflammatory genes.
      Cotreatment with LPS and sodium propionate decreased LPS-induced expression of
      inflammatory genes including IL-6, IL-8, cyclooxygenase-2, IL-1alpha,
      intercellular adhesion molecule-1, and platelet endothelial cell adhesion
      molecule-1 but not IL-1beta or lymphocyte function-associated antigen-1. Sodium
      propionate reduced LPS-induced neutrophil chemotaxis and protein secretion of the
      neutrophil chemoattractant IL-8. Finally, fetal membrane expression of GPR43 was 
      significantly higher in women delivering preterm with evidence of infection.
      GPR43-SCFA interactions may represent novel pathways that regulate inflammatory
      processes involved in human labor. Suppression of inflammatory pathways by SCFA
      may be therapeutically beneficial for pregnant women at risk of pathogen-induced 
      preterm delivery.
FAU - Voltolini, Chiara
AU  - Voltolini C
AD  - Medical Research Council Human Reproductive Sciences Unit, The Queen's Medical
      Research Institute, Edinburgh EH16 4TJ, United Kingdom. voltolini2@unisi.it
FAU - Battersby, Sharon
AU  - Battersby S
FAU - Etherington, Sophie L
AU  - Etherington SL
FAU - Petraglia, Felice
AU  - Petraglia F
FAU - Norman, Jane E
AU  - Norman JE
FAU - Jabbour, Henry N
AU  - Jabbour HN
LA  - eng
GR  - G1002033/MRC_/Medical Research Council/United Kingdom
GR  - U.1276.00.004.00002.01/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111220
PL  - United States
TA  - Endocrinology
JT  - Endocrinology
JID - 0375040
RN  - 0 (CXCL8 protein, human)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Cytokines)
RN  - 0 (FFA2R protein, human)
RN  - 0 (FFAR3 protein, human)
RN  - 0 (Fatty Acids, Volatile)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Interleukin-8)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Propionates)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - DK6Y9P42IN (sodium propionate)
SB  - IM
MH  - Cell Adhesion Molecules/genetics
MH  - Chemotaxis, Leukocyte/drug effects
MH  - Cytokines/genetics
MH  - Extraembryonic Membranes/drug effects/metabolism
MH  - Fatty Acids, Volatile/*physiology
MH  - Female
MH  - Gene Expression/drug effects
MH  - Humans
MH  - Infant, Newborn
MH  - Inflammation Mediators/*physiology
MH  - Interleukin-8/biosynthesis/genetics
MH  - Labor, Obstetric/genetics/*physiology
MH  - Lipopolysaccharides/pharmacology
MH  - Myometrium/drug effects/metabolism
MH  - Neutrophils/drug effects/physiology
MH  - Obstetric Labor, Premature/genetics/metabolism
MH  - Placenta/drug effects/metabolism
MH  - Pregnancy
MH  - Propionates/pharmacology
MH  - RNA, Messenger/genetics/metabolism
MH  - Receptors, Cell Surface/genetics/metabolism
MH  - Receptors, G-Protein-Coupled/genetics/metabolism
MH  - Tissue Culture Techniques
EDAT- 2011/12/22 06:00
MHDA- 2012/03/06 06:00
CRDT- 2011/12/22 06:00
PHST- 2011/12/22 06:00 [entrez]
PHST- 2011/12/22 06:00 [pubmed]
PHST- 2012/03/06 06:00 [medline]
AID - en.2011-1457 [pii]
AID - 10.1210/en.2011-1457 [doi]
PST - ppublish
SO  - Endocrinology. 2012 Jan;153(1):395-403. doi: 10.1210/en.2011-1457. Epub 2011 Dec 
      20.


PMID- 22185862
OWN - NLM
STAT- MEDLINE
DCOM- 20120326
LR  - 20150826
IS  - 0443-5117 (Print)
IS  - 0443-5117 (Linking)
VI  - 49
IP  - 5
DP  - 2011 Sep-Oct
TI  - [Ethics and teaching medicine. A principles declaration].
PG  - 571-4
AB  - Medicine is an old profession, having existed for twenty-four centuries. The
      ethical principles assumed since the beginning and have been enriched through
      time, culture and tradition. The stone corner of the moral commitment of
      physicians with the patient and medical students has deteriorated due to a values
      crisis. This is due to a lack of personalized and humanized care in "altars of
      progress," characterized by fragmentation of medical care, excessive use of the
      technology and merchandizing of medicine, where profits is a priority over human 
      need. The effects are unconsciousness and a lack of professional values, which
      are expressed as disloyalty, deficient solidarity, diminution of confidence,
      inequality and lack of honesty, affecting the patients and the whole medical
      relation. The problem also extends to medical education, when the students follow
      the same way to practice of physicians. To be a real educating physician in
      medicine implies an indissoluble educational symbiosis (teacher-student). When
      there is an ethical deterioration the immediate task is to propose alternative
      ethical and morals rules in medical education, which feed on values and
      traditional medicine principles.
FAU - Garcia-Vigil, Jose Luis
AU  - Garcia-Vigil JL
AD  - Comite de Etica Docente, Academia Nacional de Educacion Medica, Distrito Federal,
      Mexico. jlgarciavigil@msn.com
FAU - Garcia-Mangas, Jose Alberto
AU  - Garcia-Mangas JA
FAU - Ocampo-Martinez, Joaquin
AU  - Ocampo-Martinez J
FAU - Martinez-Gonzalez, Adrian
AU  - Martinez-Gonzalez A
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Declaracion de principios eticos del educador en medicina.
PL  - Mexico
TA  - Rev Med Inst Mex Seguro Soc
JT  - Revista medica del Instituto Mexicano del Seguro Social
JID - 101243727
SB  - IM
MH  - *Codes of Ethics
MH  - *Education, Medical
MH  - Ethics, Medical/*education
EDAT- 2011/12/22 06:00
MHDA- 2012/03/27 06:00
CRDT- 2011/12/22 06:00
PHST- 2011/12/22 06:00 [entrez]
PHST- 2011/12/22 06:00 [pubmed]
PHST- 2012/03/27 06:00 [medline]
PST - ppublish
SO  - Rev Med Inst Mex Seguro Soc. 2011 Sep-Oct;49(5):571-4.


PMID- 22185861
OWN - NLM
STAT- MEDLINE
DCOM- 20120326
LR  - 20150826
IS  - 0443-5117 (Print)
IS  - 0443-5117 (Linking)
VI  - 49
IP  - 5
DP  - 2011 Sep-Oct
TI  - [Medical expert opinion: performance, the appearance in court in cases of medical
      malpractice].
PG  - 563-70
AB  - In several lawsuits, including one for medical malpractice, there is a phase with
      the participation of experts who analyze the evidence in order to issue an
      opinion which is explained at the hearing at court, thus resulting in the medical
      expert act that all physicians should know. This article discusses legal, medical
      and ethical characteristics in an expert performance in medical malpractice
      cases. The expert having access to the original evidence is in a powerful
      situation and has an advantageous position in a trial for medical malpractice.
      His opinion has legal effects, therefore, the issue of partial, erroneous or
      badly founded points of view, and a unprepared, unethical and malicious
      performance at the hearing, produces adverse effects in the trial transcending to
      consequences to the ones involved. To apply correctly the principles of ethics
      and knowledge, the medical expert will make good use of the information obtained 
      during his research both in his opinion and during his appearance in court.
      Analyzing and using it properly, he will make his point of view meet its goal of 
      establishing the facts in the investigation of an alleged medical malpractice and
      the authorities or officials will have strong evidence to enable them to
      determine their decision, thus contributing to the development of the society and
      the proper use of the law within it.
FAU - Garcia-Garduza, Ismael
AU  - Garcia-Garduza I
AD  - Unidad Departamental de Medicina Legal, Secretaria de Salud del Gobierno del
      Distrito Federal, Mexico. isma_pumas@yahoo.com.mx
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Pericial medica: su exposicion en la comparecencia en casos de mala practica
      medica.
PL  - Mexico
TA  - Rev Med Inst Mex Seguro Soc
JT  - Revista medica del Instituto Mexicano del Seguro Social
JID - 101243727
SB  - IM
MH  - Expert Testimony/*legislation & jurisprudence
MH  - Malpractice/*legislation & jurisprudence
MH  - Mexico
EDAT- 2011/12/22 06:00
MHDA- 2012/03/27 06:00
CRDT- 2011/12/22 06:00
PHST- 2011/12/22 06:00 [entrez]
PHST- 2011/12/22 06:00 [pubmed]
PHST- 2012/03/27 06:00 [medline]
PST - ppublish
SO  - Rev Med Inst Mex Seguro Soc. 2011 Sep-Oct;49(5):563-70.


PMID- 22185277
OWN - NLM
STAT- MEDLINE
DCOM- 20120412
LR  - 20131121
IS  - 1757-6199 (Electronic)
IS  - 1757-6180 (Linking)
VI  - 3
IP  - 24
DP  - 2011 Dec
TI  - Dried matrix spot direct analysis: evaluating the robustness of a direct elution 
      technique for use in quantitative bioanalysis.
PG  - 2769-81
LID - 10.4155/bio.11.270 [doi]
AB  - BACKGROUND: The surge in interest in switching from traditionally used wet plasma
      to dried matrix spot (DMS) sampling and analysis to support pharmaceutical drug
      development is due to the significant ethical, financial and data quality
      advantages on offer. Unfortunately these advantages do not extend to sample
      bioanalysis, as DMS extraction is more complex than the protein precipitation
      method typically used for wet plasma analysis. Direct elution techniques coupled 
      to HPLC-MS/MS have been identified as a potential means to counter this
      additional complexity. RESULTS: The robustness and reproducibility of DMS
      HPLC-MS/MS data generated using a CAMAG DBS-MS 16 prototype automated direct
      elution instrument has been demonstrated to meet or exceed results obtained using
      a conventional manual extraction methodology. CONCLUSION: The data generated
      suggest that a simple and fast direct elution method of DMS samples that does not
      require additional sample or extract clean-up, offers sufficiently robust
      performance to be compatible with high-sample-throughput quantitative analysis.
      Further evaluation of the technique and the development of more advanced fully
      automated direct elution instrumentation is fully warranted.
FAU - Abu-Rabie, Paul
AU  - Abu-Rabie P
AD  - Platform Technology & Science, Drug Metabolism & Pharmacokinetics,
      GlaxoSmithKline Research & Development, Park Road, Ware, Hertfordshire, UK.
      paul.2.abu-rabie@gsk.com
FAU - Spooner, Neil
AU  - Spooner N
LA  - eng
PT  - Journal Article
PL  - England
TA  - Bioanalysis
JT  - Bioanalysis
JID - 101512484
RN  - 0 (Aminoquinolines)
RN  - 0 (Pharmaceutical Preparations)
RN  - 0 (Solvents)
RN  - 362O9ITL9D (Acetaminophen)
RN  - U34EAV21TG (8-aminoquinoline)
SB  - IM
MH  - Acetaminophen/blood
MH  - Aminoquinolines/blood
MH  - Automation
MH  - Chromatography, High Pressure Liquid
MH  - Dried Blood Spot Testing/*methods
MH  - Humans
MH  - Pharmaceutical Preparations/blood
MH  - Reproducibility of Results
MH  - Solvents/chemistry
MH  - Tandem Mass Spectrometry
EDAT- 2011/12/22 06:00
MHDA- 2012/04/13 06:00
CRDT- 2011/12/22 06:00
PHST- 2011/12/22 06:00 [entrez]
PHST- 2011/12/22 06:00 [pubmed]
PHST- 2012/04/13 06:00 [medline]
AID - 10.4155/bio.11.270 [doi]
PST - ppublish
SO  - Bioanalysis. 2011 Dec;3(24):2769-81. doi: 10.4155/bio.11.270.


PMID- 22185197
OWN - NLM
STAT- MEDLINE
DCOM- 20120315
LR  - 20211021
IS  - 1475-2875 (Electronic)
IS  - 1475-2875 (Linking)
VI  - 10
DP  - 2011 Dec 21
TI  - Spleen rates and infant parasite rates as surveillance tool for malaria control
      in remote hard to reach areas of central India.
PG  - 381
LID - 10.1186/1475-2875-10-381 [doi]
AB  - BACKGROUND: Malaria due to both Plasmodium falciparum and Plasmodium vivax is a
      major public health problem in India. The quantification of malaria transmission 
      for the classification of malaria risk has long been a concern for
      epidemiologists. Results are presented from 30 cross-sectional surveys which
      measured spleen rates (SR) and infant parasite rates (IPR) in the forested
      districts of Madhya Pradesh during malaria outbreaks to assess whether both IPR
      and SR can still be used as indicators of malaria endemicity as spleen
      examination has lost much of its value as an epidemiological indicator in areas
      where anti-malarials drugs are widely used. METHODS: Rapid fever surveys were
      carried out from door to door and all suspected malaria cases in the entire
      population of a village were screened for malaria parasites on the basis of
      clinical symptoms such as fever, chill, rigor, headache and body ache etc.
      Children between 2 and 9 years were examined for enlarged spleen according to
      Hacketts method. Finger prick blood smears were collected from all children with 
      enlarged spleen with or without fever after obtaining written informed consent
      following institutional ethical guidelines. Infants less than 1 year were also
      screened for malaria with or without fever. RESULTS: Since malaria is local and
      focal, in some areas the outbreak waned quickly in few months and in some areas
      continued for 3 to 4 years. The analysis of trend revealed that when IPR decline 
      over the years as a result of malaria intervention measures, SR also decline. In 
      case splenomegaly continues without diminution in size, it is probably due to
      recrudescence or relapse, although it is not possible to separate malaria
      parasite species on the basis of SR. CONCLUSION: Both the tools are of immense
      value in evaluating and assessing the malaria situation especially in remote
      areas where sophisticated molecular and serological techniques are difficult to
      establish. Therefore, in forested areas malaria surveillance system will require 
      adoption of multiple approaches that have proven effective now or in the past.
FAU - Shukla, Manmohan
AU  - Shukla M
AD  - National Institute of Malaria Research, Field Station, Jabalpur 482003, Madhya
      Pradesh, India.
FAU - Singh, Neeru
AU  - Singh N
FAU - Singh, Mrigendra P
AU  - Singh MP
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20111221
PL  - England
TA  - Malar J
JT  - Malaria journal
JID - 101139802
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Animals
MH  - Blood/parasitology
MH  - Child
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - India/epidemiology
MH  - Infant
MH  - Infant, Newborn
MH  - Malaria, Falciparum/*diagnosis/*epidemiology/pathology/prevention & control
MH  - Malaria, Vivax/*diagnosis/*epidemiology/pathology/prevention & control
MH  - Male
MH  - Microscopy
MH  - Middle Aged
MH  - Parasitemia/*diagnosis/parasitology
MH  - Parasitology/*methods
MH  - Plasmodium falciparum/isolation & purification
MH  - Plasmodium vivax/isolation & purification
MH  - Splenomegaly/*diagnosis/pathology
MH  - Young Adult
PMC - PMC3258211
EDAT- 2011/12/22 06:00
MHDA- 2012/03/16 06:00
CRDT- 2011/12/22 06:00
PHST- 2011/10/25 00:00 [received]
PHST- 2011/12/21 00:00 [accepted]
PHST- 2011/12/22 06:00 [entrez]
PHST- 2011/12/22 06:00 [pubmed]
PHST- 2012/03/16 06:00 [medline]
AID - 1475-2875-10-381 [pii]
AID - 10.1186/1475-2875-10-381 [doi]
PST - epublish
SO  - Malar J. 2011 Dec 21;10:381. doi: 10.1186/1475-2875-10-381.


PMID- 22184820
OWN - NLM
STAT- MEDLINE
DCOM- 20120124
LR  - 20111221
IS  - 0193-7758 (Print)
IS  - 0193-7758 (Linking)
VI  - 33
IP  - 6
DP  - 2011 Nov-Dec
TI  - When is it ethical to withhold a research incentive?
PG  - 14-6
FAU - Tomlinson, Tom
AU  - Tomlinson T
AD  - Center for Ethics and Humanities in the Life Sciences, Michigan State University,
      East Lansing, MI, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - IRB
JT  - IRB
JID - 7906878
SB  - IM
MH  - Computer Security/*ethics
MH  - Data Collection/*ethics
MH  - Gift Giving/*ethics
MH  - Humans
MH  - Patient Selection/*ethics
MH  - United States
EDAT- 2011/12/22 06:00
MHDA- 2012/01/25 06:00
CRDT- 2011/12/22 06:00
PHST- 2011/12/22 06:00 [entrez]
PHST- 2011/12/22 06:00 [pubmed]
PHST- 2012/01/25 06:00 [medline]
PST - ppublish
SO  - IRB. 2011 Nov-Dec;33(6):14-6.


PMID- 22184358
OWN - NLM
STAT- MEDLINE
DCOM- 20120221
LR  - 20211021
IS  - 1488-2329 (Electronic)
IS  - 0820-3946 (Linking)
VI  - 184
IP  - 1
DP  - 2012 Jan 10
TI  - Testing the ethics of genetic testing in sports.
PG  - E45-6
LID - 10.1503/cmaj.109-4064 [doi]
FAU - Collier, Roger
AU  - Collier R
LA  - eng
PT  - News
DEP - 20111219
PL  - Canada
TA  - CMAJ
JT  - CMAJ : Canadian Medical Association journal = journal de l'Association medicale
      canadienne
JID - 9711805
SB  - IM
MH  - Canada
MH  - Doping in Sports/*ethics
MH  - Genetic Testing/*ethics
MH  - Humans
MH  - Sports/*ethics
PMC - PMC3255207
EDAT- 2011/12/21 06:00
MHDA- 2012/02/22 06:00
CRDT- 2011/12/21 06:00
PHST- 2011/12/21 06:00 [entrez]
PHST- 2011/12/21 06:00 [pubmed]
PHST- 2012/02/22 06:00 [medline]
AID - cmaj.109-4064 [pii]
AID - 10.1503/cmaj.109-4064 [doi]
PST - ppublish
SO  - CMAJ. 2012 Jan 10;184(1):E45-6. doi: 10.1503/cmaj.109-4064. Epub 2011 Dec 19.


PMID- 22184273
OWN - NLM
STAT- MEDLINE
DCOM- 20120524
LR  - 20111220
IS  - 1735-1502 (Print)
IS  - 1735-1502 (Linking)
VI  - 10
IP  - 4
DP  - 2011 Dec
TI  - Normal range determination of lymphocytes subsets in normal adults in Iran.
PG  - 295-8
LID - 010.04/ijaai.295298 [doi]
AB  - Immunophenotyping of lymphocytes is very essential for evaluation of immune
      system. Due to the effect of environmental factors and ethical diversity on
      immune system, establishment of an internal normal range of lymphocyte subsets is
      a necessity for each population. The aim of this study was to determine the
      normal range of T and B lymphocytes, and NK cells in normal Iranian adults. Two
      hundred and thirty three Iranian normal adult volunteers took part in this study.
      Complete Blood Count (CBC) was performed for them with Sysmex (KX21) and cells
      with CD3, CD4, CD8, CD19 and CD16/56 surface markers were simultaneously detected
      by flow cytometry method with FACstar system. Their percentile and absolute count
      were determined.The volunteers were 150 male and 83 female. Mean percentages of
      lymphocyte subpopulation were: CD3 (67.66 +/-7.76), CD19 (14.41+/-5.09), CD4
      (39.22+/-6.7), CD8 (25.42 +/-5.4) and CD16/56 (10.14+/-6.42). Also, their mean
      absolute count of lymphocyte bearing CD3, CD19, CD4 and CD8 were
      1,504+/-505/microl, 332+/-186/microl, 827+/-313/microl and 522+/-185/microl,
      respectively.Our results are comparable with similar Asian results from other
      Asian population, but are different from European population, we therefore
      conclude that it is necessary for each laboratory to establish an internal normal
      range for the lymphocytes bearing above- mentioned markers.
FAU - Shokouhi Shoormasti, Raheleh
AU  - Shokouhi Shoormasti R
AD  - Children Medical Center, Tehran, Iran.
FAU - Azimdoost, Anahita
AU  - Azimdoost A
FAU - Saghafi, Shiva
AU  - Saghafi S
FAU - Movahhedi, Masood
AU  - Movahhedi M
FAU - Haghi Ashtiani, Mohammad Taghi
AU  - Haghi Ashtiani MT
FAU - Pourpak, Zahra
AU  - Pourpak Z
FAU - Eslami, Mohammad Bagher
AU  - Eslami MB
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Allergy Asthma Immunol
JT  - Iranian journal of allergy, asthma, and immunology
JID - 101146178
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Female
MH  - Humans
MH  - Immunophenotyping
MH  - *Lymphocyte Subsets/immunology
MH  - Male
MH  - Reference Values
MH  - Young Adult
EDAT- 2011/12/21 06:00
MHDA- 2012/05/25 06:00
CRDT- 2011/12/21 06:00
PHST- 2011/12/21 06:00 [entrez]
PHST- 2011/12/21 06:00 [pubmed]
PHST- 2012/05/25 06:00 [medline]
AID - 01004295298 [pii]
AID - 010.04/ijaai.295298 [doi]
PST - ppublish
SO  - Iran J Allergy Asthma Immunol. 2011 Dec;10(4):295-8. doi: 010.04/ijaai.295298.


PMID- 22183963
OWN - NLM
STAT- MEDLINE
DCOM- 20120719
LR  - 20211021
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 19
IP  - 2
DP  - 2012 Mar
TI  - Ethical challenges in home mechanical ventilation: a secondary analysis.
PG  - 233-44
LID - 10.1177/0969733011414967 [doi]
AB  - The aim of this study was to explore the ethical challenges in home mechanical
      ventilation based on a secondary analysis of qualitative empirical data. The data
      included perceptions of healthcare professionals in hospitals and community
      health services and family members of children and adults using home mechanical
      ventilation. The findings show that a number of ethical challenges, or dilemmas, 
      arise at all levels in the course of treatment: deciding who should be offered
      home mechanical ventilation, respect for patient and family wishes, quality of
      life, dignity and equal access to home mechanical ventilation. Other challenges
      were the impacts home mechanical ventilation had on the patient, the family, the 
      healthcare services and the allocation of resources. A better and broader
      understanding of these issues is crucial in order to improve the quality of care 
      for both patient and family and assist healthcare professionals involved in home 
      mechanical ventilation to make decisions for the good of the patient and his or
      her family.
FAU - Dybwik, Knut
AU  - Dybwik K
AD  - Department of Anesthesiology, Nordland Hospital, Bodoe, Norway. kdybwik@gmail.com
FAU - Nielsen, Erik Waage
AU  - Nielsen EW
FAU - Brinchmann, Berit Store
AU  - Brinchmann BS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111219
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Adult
MH  - Attitude of Health Personnel
MH  - Beneficence
MH  - Caregivers/psychology
MH  - Child
MH  - Chronic Disease/therapy
MH  - Community Health Services
MH  - Focus Groups
MH  - Health Services Accessibility/standards
MH  - Home Care Services, Hospital-Based/*ethics
MH  - Humans
MH  - Interviews as Topic
MH  - Norway
MH  - Patient Rights
MH  - *Personal Autonomy
MH  - Practice Guidelines as Topic/standards
MH  - *Professional Autonomy
MH  - Qualitative Research
MH  - *Quality of Life
MH  - Respiration, Artificial/*ethics
PMC - PMC3573680
EDAT- 2011/12/21 06:00
MHDA- 2012/07/20 06:00
CRDT- 2011/12/21 06:00
PHST- 2011/12/21 06:00 [entrez]
PHST- 2011/12/21 06:00 [pubmed]
PHST- 2012/07/20 06:00 [medline]
AID - 0969733011414967 [pii]
AID - 10.1177/0969733011414967 [doi]
PST - ppublish
SO  - Nurs Ethics. 2012 Mar;19(2):233-44. doi: 10.1177/0969733011414967. Epub 2011 Dec 
      19.


PMID- 22183420
OWN - NLM
STAT- MEDLINE
DCOM- 20140714
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 4
DP  - 2013 Dec
TI  - Using and developing role plays in teaching aimed at preparing for social
      responsibility.
PG  - 1513-27
LID - 10.1007/s11948-011-9335-6 [doi]
AB  - In this paper, we discuss the use of role plays in ethics education for
      engineering students. After presenting a rough taxonomy of different objectives, 
      we illustrate how role plays can be used to broaden students' perspectives. We do
      this on the basis of our experiences with a newly developed role play about a
      Dutch political controversy concerning pig transport. The role play is special in
      that the discussion is about setting up an institutional framework for
      responsible action that goes beyond individual action. In that sense, the role
      play serves a double purpose. It not only aims at teaching students to become
      aware of the different dimensions in decision making, it also encourages students
      to think about what such an institutional framework for responsible action might 
      possibly look like.
FAU - Doorn, Neelke
AU  - Doorn N
AD  - Department of Technology, Policy and Management, Centre for Ethics and
      Technology, Delft University of Technology/3TU, PO Box 5015, 2600 GA, Delft, The 
      Netherlands, N.Doorn@tudelft.nl.
FAU - Kroesen, J Otto
AU  - Kroesen JO
LA  - eng
PT  - Journal Article
DEP - 20111220
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
CIN - Sci Eng Ethics. 2013 Dec;19(4):1529-31. PMID: 24101438
MH  - Animals
MH  - Awareness
MH  - Curriculum
MH  - Decision Making
MH  - Engineering/education/*ethics
MH  - Ethics, Professional/*education
MH  - Humans
MH  - Netherlands
MH  - *Role Playing
MH  - *Social Responsibility
MH  - Students
MH  - Swine
MH  - Teaching/*methods
PMC - PMC3857546
EDAT- 2011/12/21 06:00
MHDA- 2014/07/16 06:00
CRDT- 2011/12/21 06:00
PHST- 2011/05/08 00:00 [received]
PHST- 2011/11/25 00:00 [accepted]
PHST- 2011/12/21 06:00 [entrez]
PHST- 2011/12/21 06:00 [pubmed]
PHST- 2014/07/16 06:00 [medline]
AID - 10.1007/s11948-011-9335-6 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Dec;19(4):1513-27. doi: 10.1007/s11948-011-9335-6. Epub 2011
      Dec 20.


PMID- 22182224
OWN - NLM
STAT- MEDLINE
DCOM- 20120521
LR  - 20111220
IS  - 1532-849X (Electronic)
IS  - 1059-941X (Linking)
VI  - 20
IP  - 8
DP  - 2011 Dec
TI  - Longitudinal clinical evaluation of undercut areas and rest seats of abutment
      teeth in removable partial denture treatment.
PG  - 639-42
LID - 10.1111/j.1532-849X.2011.00766.x [doi]
AB  - PURPOSE: Adequate preparation of abutment teeth for removable partial denture
      (RPD) rest seats allows appropriate masticatory force transmission, retention,
      and stability of supporting structures. It follows that careful preparation will 
      be important for the longevity of the rehabilitation. The present study aimed to 
      clinically evaluate rest seats and undercut areas of abutment teeth in RPD
      wearers after 2 years of use. MATERIALS AND METHODS: A total of 193 occlusal,
      incisal, and cingulum rest seats were evaluated in terms of shape, rest
      adaptation, wear, caries, fractures, and surface type (enamel, composite resin,
      or amalgam). Two hundred and fourteen undercut areas were evaluated in terms of
      surface type (enamel or restoration) and integrity. This study was approved by
      the Research Ethics Committee of the Federal University of Rio Grande do Norte,
      resolution 196/1996, protocol number 11/05. RESULTS: Intact preparations
      accounted for 92.2% of the total. Application of the Pearson test (p= 0.289)
      found no statistically significant differences among the materials on which the
      rest seats were prepared. For the undercut areas, 20.7% of those obtained on
      restorative material were nonintact. In addition, Fisher's exact test showed a
      statistically significant difference (p= 0.001) in surface type; enamel surfaces 
      were shown to be 14 times more stable than restored surfaces. CONCLUSIONS: The
      results of this study suggest that rest seats are stable, regardless of the
      material on which they are prepared. Retentive areas were shown to be more stable
      when they were located in enamel.
CI  - (c) 2011 by the American College of Prosthodontists.
FAU - de Aquino, Ana Rafaela Luz
AU  - de Aquino AR
AD  - State University of Rio Grande do Norte. (UERN), Caico, Brazil.
      anarafaela.luz@terra.com.br
FAU - Barreto, Alessandra Oliveira
AU  - Barreto AO
FAU - de Aquino, Luana Maria Martins
AU  - de Aquino LM
FAU - Ferreira, Angela Maria Fernandes
AU  - Ferreira AM
FAU - Carreiro, Adriana da Fonte Porto
AU  - Carreiro Ada F
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - J Prosthodont
JT  - Journal of prosthodontics : official journal of the American College of
      Prosthodontists
JID - 9301275
RN  - 0 (Composite Resins)
RN  - 8049-85-2 (Dental Amalgam)
MH  - Chi-Square Distribution
MH  - Cohort Studies
MH  - Composite Resins
MH  - *Dental Abutments
MH  - Dental Amalgam
MH  - Dental Enamel
MH  - *Denture, Partial, Removable
MH  - Humans
MH  - Prospective Studies
MH  - Statistics, Nonparametric
MH  - Surface Properties
MH  - *Tooth Preparation
EDAT- 2011/12/21 06:00
MHDA- 2012/05/23 06:00
CRDT- 2011/12/21 06:00
PHST- 2011/12/21 06:00 [entrez]
PHST- 2011/12/21 06:00 [pubmed]
PHST- 2012/05/23 06:00 [medline]
AID - 10.1111/j.1532-849X.2011.00766.x [doi]
PST - ppublish
SO  - J Prosthodont. 2011 Dec;20(8):639-42. doi: 10.1111/j.1532-849X.2011.00766.x.


PMID- 22181041
OWN - NLM
STAT- MEDLINE
DCOM- 20120531
LR  - 20151119
IS  - 1502-7708 (Electronic)
IS  - 0036-5521 (Linking)
VI  - 47
IP  - 3
DP  - 2012 Mar
TI  - Predictive biomarkers in colorectal cancer: usage, validation, and design in
      clinical trials.
PG  - 356-62
LID - 10.3109/00365521.2012.640836 [doi]
AB  - As cancer treatment development has shifted its attention to targeted therapies, 
      it is becoming increasingly important to provide tools for selecting the right
      treatment for an individual patient to achieve optimal clinical benefit.
      Biomarkers, identified and studied in the process of understanding the nature of 
      the disease at the molecular pathogenesis level, have been increasingly
      recognized as a critical aspect in more accurate diagnosis, prognosis assessment,
      and therapeutic targeting. Predictive biomarkers, which can aid treatment
      decisions, require extensive data for validation. In this article, we discuss the
      definition, clinical usages, and more extensively the clinical trial designs for 
      the validation of predictive biomarkers. Predictive biomarker validation methods 
      can be broadly grouped into retrospective and prospective designs. Retrospective 
      validation utilizes data from previously conducted prospective randomized
      controlled trials. Prospective designs include enrichment designs,
      treatment-by-marker interaction designs, marker-based strategy designs, and
      adaptive designs. We discuss each design with examples and provide comparisons of
      the advantages and disadvantages among the different designs. We conclude that
      the combination of scientific, clinical, statistical, ethical, and practical
      considerations provides guidance for the choice of the clinical trial design for 
      validation of each proposed predictive biomarker.
FAU - Shi, Qian
AU  - Shi Q
AD  - Department of Health Science Research, Mayo Clinic, Rochester, MN 55905, USA.
FAU - Mandrekar, Sumithra J
AU  - Mandrekar SJ
FAU - Sargent, Daniel J
AU  - Sargent DJ
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111219
PL  - England
TA  - Scand J Gastroenterol
JT  - Scandinavian journal of gastroenterology
JID - 0060105
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Biomarkers, Tumor/*analysis
MH  - Clinical Trials as Topic
MH  - Colorectal Neoplasms/*metabolism/*pathology/*therapy
MH  - Decision Making
MH  - Humans
MH  - Predictive Value of Tests
MH  - *Research Design
EDAT- 2011/12/21 06:00
MHDA- 2012/06/01 06:00
CRDT- 2011/12/21 06:00
PHST- 2011/12/21 06:00 [entrez]
PHST- 2011/12/21 06:00 [pubmed]
PHST- 2012/06/01 06:00 [medline]
AID - 10.3109/00365521.2012.640836 [doi]
PST - ppublish
SO  - Scand J Gastroenterol. 2012 Mar;47(3):356-62. doi: 10.3109/00365521.2012.640836. 
      Epub 2011 Dec 19.


PMID- 22181027
OWN - NLM
STAT- MEDLINE
DCOM- 20120702
LR  - 20120228
IS  - 1939-1536 (Electronic)
IS  - 0033-3204 (Linking)
VI  - 49
IP  - 1
DP  - 2012 Mar
TI  - Obtaining clinical writing informed consent versus using client disguise and
      recommendations for practice.
PG  - 3-11
LID - 10.1037/a0025059 [doi]
AB  - Clinical writing about psychotherapy clients has long been a part of didactic
      texts and research articles because it allows new treatments and interventions to
      be presented in an effective and memorable way. The main ways that clinicians
      write about their clients include obtaining informed consent, using client
      disguise, or creating case composites. Although many clinicians use a combination
      of all three approaches, this article specifically addresses the implications of 
      using clinical writing informed consent. The present article begins with a brief 
      history of clinical writing and an examination of the relevant standards in the
      current APA Ethics Code and the Health Insurance Portability and Accountability
      Act; this is followed by a discussion of the benefits of engaging in the clinical
      writing informed consent process. Subsequently, the limitations of using clinical
      writing informed consent are explored, including the potentially negative impact 
      on the therapeutic alliance and the client's progress. The article concludes that
      clinicians should be cautious when deciding to engage in clinical writing
      informed consent. Recommendations in the form of a checklist are provided to help
      clinicians identify when it is most appropriate to use client disguise or case
      composites, and how to do so, as well as when it is appropriate to engage in
      clinical writing informed consent. Future directions are considered.
CI  - PsycINFO Database Record (c) 2012 APA, all rights reserved
FAU - Sieck, Barbara C
AU  - Sieck BC
AD  - Department of Psychological and Quantitative Foundations, 361 Lindquist Center,
      University of Iowa, Iowa City, IA 52242, USA. barbara-sieck@uiowa.edu
LA  - eng
PT  - Journal Article
DEP - 20111219
PL  - United States
TA  - Psychotherapy (Chic)
JT  - Psychotherapy (Chicago, Ill.)
JID - 2984829R
SB  - IM
CIN - Psychotherapy (Chic). 2012 Mar;49(1):12-5. PMID: 22181023
CIN - Psychotherapy (Chic). 2012 Mar;49(1):16-8. PMID: 22369077
CIN - Psychotherapy (Chic). 2012 Mar;49(1):19-21. PMID: 22369078
CIN - Psychotherapy (Chic). 2012 Mar;49(1):22-5. PMID: 22369079
MH  - Codes of Ethics
MH  - *Ethics, Professional
MH  - Humans
MH  - Informed Consent/*ethics/*legislation & jurisprudence
MH  - Professional-Patient Relations/*ethics
MH  - Psychotherapy/*ethics
MH  - Publishing/*ethics
MH  - Societies, Scientific
MH  - United States
MH  - *Writing
EDAT- 2011/12/21 06:00
MHDA- 2012/07/03 06:00
CRDT- 2011/12/21 06:00
PHST- 2011/12/21 06:00 [entrez]
PHST- 2011/12/21 06:00 [pubmed]
PHST- 2012/07/03 06:00 [medline]
AID - 2011-29351-001 [pii]
AID - 10.1037/a0025059 [doi]
PST - ppublish
SO  - Psychotherapy (Chic). 2012 Mar;49(1):3-11. doi: 10.1037/a0025059. Epub 2011 Dec
      19.


PMID- 22181023
OWN - NLM
STAT- MEDLINE
DCOM- 20120702
LR  - 20181201
IS  - 1939-1536 (Electronic)
IS  - 0033-3204 (Linking)
VI  - 49
IP  - 1
DP  - 2012 Mar
TI  - Clinical writing about clients: is informed consent sufficient?
PG  - 12-5
LID - 10.1037/a0025249 [doi]
AB  - The use of client information in clinical writings or presentations may be very
      helpful in advancing the knowledge base of the profession. Yet, the very act of
      asking a client for permission to use their treatment information in this way may
      be detrimental to the therapeutic alliance and treatment process. As such, great 
      care must be taken in how such issues are considered and acted upon. Sieck's
      article (2011, Obtaining clinical writing informed consent versus using client
      disguise and recommendations for practice. Psychotherapy, 49, pp. 3-11.) on the
      use of informed consent for obtaining permission to use a client's treatment
      information for professional writing and presentations is examined and discussed.
      The nature and role of the informed consent process is accentuated;
      psychotherapist needs and goals and client vulnerabilities are each addressed in 
      the context of the relevant sections of the APA Ethics Code and each
      psychotherapist's obligation to act only in ways consistent with each client's
      best interests. Recommendations for a thoughtful consideration of these issues
      are presented, consistent with Sieck's proposed decision-making process for use
      in these situations.
CI  - PsycINFO Database Record (c) 2012 APA, all rights reserved
FAU - Barnett, Jeffrey E
AU  - Barnett JE
AD  - Department of Psychology, Loyola University Maryland, 4501North Charles Street,
      Baltimore, MD 21210, USA. jbarnett@loyola.edu
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20111219
PL  - United States
TA  - Psychotherapy (Chic)
JT  - Psychotherapy (Chicago, Ill.)
JID - 2984829R
SB  - IM
CON - Psychotherapy (Chic). 2012 Mar;49(1):3-11. PMID: 22181027
MH  - *Ethics, Professional
MH  - Humans
MH  - Informed Consent/*ethics/*legislation & jurisprudence
MH  - Professional-Patient Relations/*ethics
MH  - Psychotherapy/*ethics
MH  - Publishing/*ethics
MH  - *Writing
EDAT- 2011/12/21 06:00
MHDA- 2012/07/03 06:00
CRDT- 2011/12/21 06:00
PHST- 2011/12/21 06:00 [entrez]
PHST- 2011/12/21 06:00 [pubmed]
PHST- 2012/07/03 06:00 [medline]
AID - 2011-29352-001 [pii]
AID - 10.1037/a0025249 [doi]
PST - ppublish
SO  - Psychotherapy (Chic). 2012 Mar;49(1):12-5. doi: 10.1037/a0025249. Epub 2011 Dec
      19.


PMID- 22181000
OWN - NLM
STAT- MEDLINE
DCOM- 20120802
LR  - 20120320
IS  - 1939-1315 (Electronic)
IS  - 0022-3514 (Linking)
VI  - 102
IP  - 4
DP  - 2012 Apr
TI  - Memory lane and morality: how childhood memories promote prosocial behavior.
PG  - 743-58
LID - 10.1037/a0026565 [doi]
AB  - Although research has established that autobiographical memory affects one's
      self-concept, little is known about how it affects moral behavior. We focus on a 
      specific type of autobiographical memory: childhood memories. Drawing on research
      on memory and moral psychology, we propose that childhood memories elicit moral
      purity, which we define as a psychological state of feeling morally clean and
      innocent. In turn, heightened moral purity leads to greater prosocial behavior.
      In Experiment 1, participants instructed to recall childhood memories were more
      likely to help the experimenter with a supplementary task than were participants 
      in a control condition, and this effect was mediated by moral purity. In
      Experiment 2, the same manipulation increased the amount of money participants
      donated to a good cause, and both implicit and explicit measures of moral purity 
      mediated the effect. Experiment 3 provides further support for the process
      linking childhood memories and prosocial behavior through moderation. In
      Experiment 4, we found that childhood memories led to punishment of others'
      ethically questionable actions. Finally, in Experiment 5, both positively
      valenced and negatively valenced childhood memories increased helping compared to
      a control condition.
FAU - Gino, Francesca
AU  - Gino F
AD  - Organizations & Markets Unit, Harvard Business School, Harvard University.
      fgino@hbs.edu
FAU - Desai, Sreedhari D
AU  - Desai SD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111219
PL  - United States
TA  - J Pers Soc Psychol
JT  - Journal of personality and social psychology
JID - 0014171
SB  - IM
MH  - Adult
MH  - Aged
MH  - Emotions/*physiology
MH  - Female
MH  - *Helping Behavior
MH  - Humans
MH  - Male
MH  - *Memory, Episodic
MH  - Middle Aged
MH  - *Morals
MH  - Psychological Tests
MH  - Punishment/psychology
MH  - *Social Behavior
MH  - Time Factors
MH  - Young Adult
EDAT- 2011/12/21 06:00
MHDA- 2012/08/03 06:00
CRDT- 2011/12/21 06:00
PHST- 2011/12/21 06:00 [entrez]
PHST- 2011/12/21 06:00 [pubmed]
PHST- 2012/08/03 06:00 [medline]
AID - 2011-29364-001 [pii]
AID - 10.1037/a0026565 [doi]
PST - ppublish
SO  - J Pers Soc Psychol. 2012 Apr;102(4):743-58. doi: 10.1037/a0026565. Epub 2011 Dec 
      19.


PMID- 22180833
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1948-9366 (Electronic)
VI  - 3
IP  - 11
DP  - 2011 Nov 27
TI  - Current status and recent advances of liver transplantation from donation after
      cardiac death.
PG  - 167-76
LID - 10.4240/wjgs.v3.i11.167 [doi]
AB  - The last decade saw increased organ donation activity from donors after cardiac
      death (DCD). This contributed to a significant proportion of transplant activity.
      Despite certain drawbacks, liver transplantation from DCD donors continues to
      supplement the donor pool on the backdrop of a severe organ shortage.
      Understanding the pathophysiology has provided the basis for modulation of DCD
      organs that has been proven to be effective outside liver transplantation but
      remains experimental in liver transplantation models. Research continues on how
      best to further increase the utility of DCD grafts. Most of the work has been
      carried out exploring the use of organ preservation using machine assisted
      perfusion. Both ex-situ and in-situ organ perfusion systems are tested in the
      liver transplantation setting with promising results. Additional techniques
      involved pharmacological manipulation of the donor, graft and the recipient.
      Ethical barriers and end-of-life care pathways are obstacles to widespread
      clinical application of some of the recent advances to practice. It is likely
      that some of the DCD offers are in fact probably "prematurely" offered without
      ideal donor management or even prior to brain death being established. The
      absolute benefits of DCD exist only if this form of donation supplements the
      existing deceased donor pool; hence, it is worthwhile revisiting organ donation
      process enabling us to identify counter remedial measures.
FAU - Perera, M Thamara Pr
AU  - Perera MT
AD  - M Thamara PR Perera, Simon R Bramhall, The Liver Unit, Queen Elizabeth Hospital, 
      Edgbaston, Birmingham B15 2TH, United Kingdom.
FAU - Bramhall, Simon R
AU  - Bramhall SR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Gastrointest Surg
JT  - World journal of gastrointestinal surgery
JID - 101532473
PMC - PMC3240676
OTO - NOTNLM
OT  - Liver graft
OT  - Modulation
OT  - Non-heart beating donor
OT  - Primary non-function
OT  - Reperfusion injury
EDAT- 2011/12/20 06:00
MHDA- 2011/12/20 06:01
CRDT- 2011/12/20 06:00
PHST- 2011/07/30 00:00 [received]
PHST- 2011/10/21 00:00 [revised]
PHST- 2011/10/28 00:00 [accepted]
PHST- 2011/12/20 06:00 [entrez]
PHST- 2011/12/20 06:00 [pubmed]
PHST- 2011/12/20 06:01 [medline]
AID - 10.4240/wjgs.v3.i11.167 [doi]
PST - ppublish
SO  - World J Gastrointest Surg. 2011 Nov 27;3(11):167-76. doi:
      10.4240/wjgs.v3.i11.167.


PMID- 22180215
OWN - NLM
STAT- MEDLINE
DCOM- 20120619
LR  - 20220321
IS  - 1522-2586 (Electronic)
IS  - 1053-1807 (Linking)
VI  - 35
IP  - 3
DP  - 2012 Mar
TI  - Radiology's ethical responsibility for healthcare reform: tempering the
      overutilization of medical imaging and trimming down a heavyweight.
PG  - 512-7
LID - 10.1002/jmri.23530 [doi]
AB  - In this review we describe the problem of overutilization of high-cost imaging
      modalities, especially magnetic resonance imaging (MRI) and computed tomography
      (CT). The overuse of CT is numerically more dramatic and also carries with it the
      not insignificant risk of harm to patients, namely, induction of
      radiation-induced malignancies. We report what is known of these risks in various
      imaging scenarios. The use of Radiology Business Managers is described as a means
      adopted to control overuse and the limitations of this strategy. The imperative
      of appropriate utilization is focused on, with emphasis placed on computer-based 
      medical decision support. Impediments to appropriate use, however, exist, with
      concerns of medicolegal liability high on the list of these issues. Finally, we
      recommend that radiologists take the lead in the reform process by implementing
      strategies such as decision support.
CI  - Copyright (c) 2011 Wiley Periodicals, Inc.
FAU - Armao, Diane
AU  - Armao D
AD  - Department of Radiology, University of North Carolina at Chapel Hill, Chapel
      Hill, North Carolina, USA.
FAU - Semelka, Richard C
AU  - Semelka RC
FAU - Elias, Jorge Jr
AU  - Elias J Jr
LA  - eng
PT  - Journal Article
DEP - 20111216
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
SB  - IM
MH  - Accreditation
MH  - Decision Support Techniques
MH  - Diagnostic Imaging/economics/*statistics & numerical data
MH  - Health Care Costs
MH  - Health Care Reform/*ethics
MH  - Health Services Misuse/*trends
MH  - Humans
MH  - Liability, Legal
MH  - Radiation Dosage
MH  - Radiation Protection
MH  - Radiology/*ethics
MH  - Risk Factors
MH  - United States
MH  - Utilization Review
EDAT- 2011/12/20 06:00
MHDA- 2012/06/20 06:00
CRDT- 2011/12/20 06:00
PHST- 2011/09/02 00:00 [received]
PHST- 2011/11/09 00:00 [accepted]
PHST- 2011/12/20 06:00 [entrez]
PHST- 2011/12/20 06:00 [pubmed]
PHST- 2012/06/20 06:00 [medline]
AID - 10.1002/jmri.23530 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2012 Mar;35(3):512-7. doi: 10.1002/jmri.23530. Epub 2011
      Dec 16.


PMID- 22180170
OWN - NLM
STAT- MEDLINE
DCOM- 20130128
LR  - 20120723
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 8
DP  - 2012 Aug
TI  - Ethics, organ donation and tax: a proposal.
PG  - 451-7
LID - 10.1136/medethics-2011-100163 [doi]
AB  - Five arguments are presented in favour of the proposal that people who opt in as 
      organ donors should receive a tax break. These arguments appeal to welfare,
      autonomy, fairness, distributive justice and self-ownership, respectively. Eight 
      worries about the proposal are considered in this paper. These objections focus
      upon no-effect and counter-productiveness, the Titmuss concern about social
      meaning, exploitation of the poor, commodification, inequality and unequal
      status, the notion that there are better alternatives, unacceptable expense, and 
      concerns about the veto of relatives. The paper argues that none of the
      objections to the proposal is very telling.
FAU - Sobirk Petersen, Thomas
AU  - Sobirk Petersen T
AD  - Department of Philosophy, University of Roskilde, Roskilde 4000, Denmark.
      thomassp@ruc.dk
FAU - Lippert-Rasmussen, Kasper
AU  - Lippert-Rasmussen K
LA  - eng
PT  - Journal Article
DEP - 20111217
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Capitation Fee/ethics
MH  - Commodification
MH  - Denmark
MH  - Developed Countries
MH  - Humans
MH  - Ownership
MH  - Personal Autonomy
MH  - Poverty
MH  - Social Justice
MH  - Tax Exemption/*economics
MH  - *Tissue Donors/ethics
MH  - Tissue and Organ Procurement/*economics/*ethics
MH  - Vulnerable Populations
EDAT- 2011/12/20 06:00
MHDA- 2013/01/29 06:00
CRDT- 2011/12/20 06:00
PHST- 2011/12/20 06:00 [entrez]
PHST- 2011/12/20 06:00 [pubmed]
PHST- 2013/01/29 06:00 [medline]
AID - medethics-2011-100163 [pii]
AID - 10.1136/medethics-2011-100163 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Aug;38(8):451-7. doi: 10.1136/medethics-2011-100163. Epub 2011
      Dec 17.


PMID- 22179595
OWN - NLM
STAT- MEDLINE
DCOM- 20130509
LR  - 20121128
IS  - 1477-030X (Electronic)
IS  - 0269-2163 (Linking)
VI  - 26
IP  - 8
DP  - 2012 Dec
TI  - Using observation as a data collection method to help understand patient and
      professional roles and actions in palliative care settings.
PG  - 1048-54
LID - 10.1177/0269216311432897 [doi]
AB  - BACKGROUND: Observational research methods are important for understanding
      people's actions, roles and behaviour. However, these techniques are underused
      generally in healthcare research, including research in the palliative care
      field. AIM: The aim in this paper is to place qualitative observational data
      collection methods in their methodological context and provide an overview of
      issues to consider when using observation as a method of data collection. This
      paper discusses practical considerations when conducting palliative care research
      using observation. FINDINGS: Observational data collection methods span research 
      paradigms, and qualitative approaches contribute by their focus on 'natural'
      settings which allow the explanation of social processes and phenomena. In
      particular, they can facilitate understanding of what people do and how these can
      alter in response to situations and over time, especially where people find their
      own practice difficult to articulate. Observational studies can be challenging to
      carry out: we focus on the potentially problematic areas of sampling, consent and
      ethics, data collection and recording, data management and analysis. CONCLUSION: 
      Qualitative observational data collection methods can contribute to theoretical
      and conceptual development and the explanation of social processes in palliative 
      care. In particular this contribution to understanding care structures and
      processes should improve understanding of patients' experiences of their care
      journey and thus impact on care outcomes.
FAU - Walshe, Catherine
AU  - Walshe C
AD  - The School of Nursing, Midwifery and Social Work, University of Manchester, UK.
      catherine.walshe@manchester.ac.uk
FAU - Ewing, Gail
AU  - Ewing G
FAU - Griffiths, Jane
AU  - Griffiths J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20111216
PL  - England
TA  - Palliat Med
JT  - Palliative medicine
JID - 8704926
SB  - IM
MH  - Data Collection/methods
MH  - Health Services Research/methods/standards
MH  - Humans
MH  - Palliative Care/*methods/standards
MH  - Patients/*psychology
MH  - Professional Role/*psychology
EDAT- 2011/12/20 06:00
MHDA- 2013/05/10 06:00
CRDT- 2011/12/20 06:00
PHST- 2011/12/20 06:00 [entrez]
PHST- 2011/12/20 06:00 [pubmed]
PHST- 2013/05/10 06:00 [medline]
AID - 0269216311432897 [pii]
AID - 10.1177/0269216311432897 [doi]
PST - ppublish
SO  - Palliat Med. 2012 Dec;26(8):1048-54. doi: 10.1177/0269216311432897. Epub 2011 Dec
      16.


PMID- 22179465
OWN - NLM
STAT- MEDLINE
DCOM- 20120723
LR  - 20211021
IS  - 1432-2218 (Electronic)
IS  - 0930-2794 (Linking)
VI  - 26
IP  - 6
DP  - 2012 Jun
TI  - Retroperitoneoscopic pancreatectomy: a new surgical option for pancreatic
      disease.
PG  - 1609-16
LID - 10.1007/s00464-011-2078-2 [doi]
AB  - OBJECTIVE: The advantage of retroperitoneoscopy in renal and adrenal gland
      surgery has been widely acknowledged. Retroperitoneoscopy may also be a useful
      approach to the pancreas, a retroperitoneal organ. This study aims to evaluate
      the feasibility of retroperitoneoscopic pancreatectomy performed in an animal
      model and a small patient cohort. METHODS: This study was divided into two
      stages. Initially, retroperitoneoscopic distal pancreatectomy was performed in
      6-month-old Yorkshire breed piglets (n = 5; mean weight, 50 +/- 5 kg).
      Subsequently, seven patients with suspected diagnosis of distal pancreatic
      lesions were selected between February 2010 and April 2011 to undergo
      retroperitoneoscopy. Approval was obtained from both the Animal Ethics Committee 
      and the Institutional Review Board. RESULTS: In the animal models,
      retroperitoneoscopic procedures were accomplished smoothly with short operative
      time, insignificant blood loss, and only minor complications. In clinical
      practice, patients with histologically confirmed pancreatic diseases underwent
      enucleation (n = 2) or distal pancreatectomy with splenic preservation (n = 2).
      Operative times ranged from 30 to 100 min with controllable blood loss of 10-100 
      ml. One case of intraoperative retroperitoneal perforation and two cases of
      pancreatic fistula occurred. All four patients were discharged within 7 days
      postoperatively. The other three patients with nonpancreatic diseases underwent
      retroperitoneoscopic resection with excellent clinical outcome. CONCLUSIONS: The 
      results of this preliminary study demonstrate that retroperitoneoscopic
      pancreatectomy, a novel surgical approach, was feasible and effective in selected
      patients. The advantages of this approach include acceptable operating time,
      insignificant blood loss, simple manipulations, minor complications, and
      excellent postoperative recovery time. Additionally, this study suggests that
      retroperitoneoscopy could also be feasible for treatment of retroperitoneal
      nonpancreatic diseases.
FAU - Zhao, Guodong
AU  - Zhao G
AD  - Department of Surgical Oncology, Chinese People's Liberation Army General
      Hospital, 28 Fuxing Road, Beijing 100853, China.
FAU - Xue, Ruihua
AU  - Xue R
FAU - Ma, Xin
AU  - Ma X
FAU - Hu, Minggen
AU  - Hu M
FAU - Gu, Xinjin
AU  - Gu X
FAU - Wang, Baofu
AU  - Wang B
FAU - Zhang, Xu
AU  - Zhang X
FAU - Liu, Rong
AU  - Liu R
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20111217
PL  - Germany
TA  - Surg Endosc
JT  - Surgical endoscopy
JID - 8806653
SB  - IM
MH  - Adult
MH  - Animals
MH  - Blood Loss, Surgical/statistics & numerical data
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Laparoscopy/*methods
MH  - Male
MH  - Middle Aged
MH  - Pancreatectomy/*methods
MH  - Pancreatic Diseases/*surgery
MH  - Postoperative Complications/etiology
MH  - Retroperitoneal Space
MH  - Sus scrofa
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2011/12/20 06:00
MHDA- 2012/07/24 06:00
CRDT- 2011/12/20 06:00
PHST- 2011/04/28 00:00 [received]
PHST- 2011/11/09 00:00 [accepted]
PHST- 2011/12/20 06:00 [entrez]
PHST- 2011/12/20 06:00 [pubmed]
PHST- 2012/07/24 06:00 [medline]
AID - 10.1007/s00464-011-2078-2 [doi]
PST - ppublish
SO  - Surg Endosc. 2012 Jun;26(6):1609-16. doi: 10.1007/s00464-011-2078-2. Epub 2011
      Dec 17.


PMID- 22179161
OWN - NLM
STAT- MEDLINE
DCOM- 20120821
LR  - 20220629
IS  - 1980-5322 (Electronic)
IS  - 1807-5932 (Linking)
VI  - 66
IP  - 9
DP  - 2011
TI  - End of life in the neonatal intensive care unit.
PG  - 1569-72
LID - S1807-59322011000900011 [pii]
AB  - PURPOSE: Death at the beginning of life is tragic but not uncommon in neonatal
      intensive care units. In Portugal, few studies have examined the circumstances
      surrounding the final moments of neonates. We evaluated the care given to
      neonates and their families in terminal situations and the changes that had
      occurred one decade later. DESIGN AND METHODS: We analyzed 256 charts in a
      retrospective chart review of neonatal deaths between two periods (1992-1995 and 
      2002-2005) in a level III neonatal intensive care unit. RESULTS: Our results show
      differences in the care of dying infants between the two periods. The analysis of
      the 2002-2005 cohort four years revealed more withholding and withdrawing of
      therapeutic activities and more effective pain and distress relief; however, on
      the final day of life, 95.7% of the infants received invasive ventilatory
      support, 76.3% received antibiotics, 58.1% received inotropics, and 25.8%
      received no opioid or sedative administration. The 2002-2005 cohort had more
      spiritual advisor solicitation, a higher number of relatives with permission to
      freely visit and more clinical meetings with neonatologists. Interventions by
      parents, healthcare providers and ethics committees during decision-making were
      not documented in any of the charts. Only eight written orders regarding
      therapeutic limitations and the adoption of palliative care were documented;
      seven (87.5%) were from the 2002-2005 cohort. Parental presence during death was 
      more frequent in the latter four years (2002-2005 cohort), but only 21.5% of the 
      parents wanted to be present at that moment. CONCLUSION: Despite an increase in
      the withholding and withdrawing of therapeutic activities and improvements in
      pain management and family support, many neonates still receive curative and
      aggressive practices at the end of life.
FAU - Moura, Helena
AU  - Moura H
AD  - Servico de Neonatologia do Centro Hospitalar Porto, Portugal.
FAU - Costa, Vera
AU  - Costa V
FAU - Rodrigues, Manuela
AU  - Rodrigues M
FAU - Almeida, Filipe
AU  - Almeida F
FAU - Maia, Teresa
AU  - Maia T
FAU - Guimaraes, Hercilia
AU  - Guimaraes H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clinics (Sao Paulo)
JT  - Clinics (Sao Paulo, Brazil)
JID - 101244734
SB  - IM
MH  - Decision Making/*physiology
MH  - Humans
MH  - Infant, Newborn
MH  - Intensive Care Units, Neonatal/*standards
MH  - Life Support Care/*methods/statistics & numerical data
MH  - Pain Management/*methods/statistics & numerical data
MH  - Parents
MH  - Portugal
MH  - Retrospective Studies
MH  - Terminal Care/*methods
MH  - Time Factors
MH  - Visitors to Patients/statistics & numerical data
MH  - Withholding Treatment/*standards
PMC - PMC3164406
EDAT- 2011/12/20 06:00
MHDA- 2012/08/22 06:00
CRDT- 2011/12/20 06:00
PHST- 2011/02/25 00:00 [received]
PHST- 2011/05/25 00:00 [accepted]
PHST- 2011/12/20 06:00 [entrez]
PHST- 2011/12/20 06:00 [pubmed]
PHST- 2012/08/22 06:00 [medline]
AID - S1807-5932(22)01945-7 [pii]
AID - 10.1590/s1807-59322011000900011 [doi]
PST - ppublish
SO  - Clinics (Sao Paulo). 2011;66(9):1569-72. doi: 10.1590/s1807-59322011000900011.


PMID- 22179074
OWN - NLM
STAT- MEDLINE
DCOM- 20120605
LR  - 20161125
IS  - 1662-8063 (Electronic)
IS  - 1662-4246 (Linking)
VI  - 15
IP  - 2
DP  - 2012
TI  - An Australian approach to the policy translation of deliberated citizen
      perspectives on biobanking.
PG  - 82-91
LID - 10.1159/000334104 [doi]
AB  - BACKGROUND: Deliberative public engagement is recommended for policy development 
      in contested ethical areas. Scholars provide little guidance on how deliberative 
      outputs can be translated to policy. This paper describes the processes we
      undertook to design a deliberative public forum for citizens to develop
      recommendations on biobanking that were adopted as health policy. METHOD: The
      4-day forum, held in 2008 in Perth, Western Australia, was designed in
      collaboration with academic experts. Deliberant recommendations were recorded in 
      a formal report presented to policy-makers. Deliberations were audio-taped and
      transcribed. Translation involved transcript analyses, comparison of
      recommendations to other stakeholder views and post-forum consultations. RESULTS:
      Sixteen citizens made recommendations on ethical, legal and social issues related
      to biobanking. Most recommendations were translated into biobanking guidelines,
      with which Western Australia government health agencies must comply. The value of
      deliberative public participation in policy-making was most evident when
      trade-offs in competing interests, hopes and concerns were required. Translation 
      issues included the impact of a small number of participants with limited
      socio-demographic diversity on procedural and policy legitimacy. CONCLUSIONS:
      Assessing the sufficiency of diversity in citizen representation was central to
      the deliberation-to-translation process. Institutional context facilitated the
      uptake of deliberation and translation processes. The use of these processes
      influenced policy substance and credibility among stakeholders and contributed to
      the state government directive that policy compliance be mandatory. We urge
      others to publish deliberation-to-translation processes so that best-practices
      may be identified.
CI  - Copyright (c) 2011 S. Karger AG, Basel.
FAU - Molster, Caron
AU  - Molster C
AD  - Office of Population Health Genomics, Department of Health, Curtin University of 
      Technology, Perth, WA, Australia. caron.molster@health.wa.gov.au
FAU - Maxwell, Susannah
AU  - Maxwell S
FAU - Youngs, Leanne
AU  - Youngs L
FAU - Potts, Ayla
AU  - Potts A
FAU - Kyne, Gaenor
AU  - Kyne G
FAU - Hope, Fiona
AU  - Hope F
FAU - Dawkins, Hugh
AU  - Dawkins H
FAU - O'Leary, Peter
AU  - O'Leary P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111214
PL  - Switzerland
TA  - Public Health Genomics
JT  - Public health genomics
JID - 101474167
SB  - IM
MH  - Biological Specimen Banks/*ethics/*legislation & jurisprudence
MH  - *Community Participation
MH  - Expert Testimony
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Policy Making
MH  - *Public Opinion
MH  - Western Australia
EDAT- 2011/12/20 06:00
MHDA- 2012/06/06 06:00
CRDT- 2011/12/20 06:00
PHST- 2011/04/06 00:00 [received]
PHST- 2011/09/21 00:00 [accepted]
PHST- 2011/12/20 06:00 [entrez]
PHST- 2011/12/20 06:00 [pubmed]
PHST- 2012/06/06 06:00 [medline]
AID - 000334104 [pii]
AID - 10.1159/000334104 [doi]
PST - ppublish
SO  - Public Health Genomics. 2012;15(2):82-91. doi: 10.1159/000334104. Epub 2011 Dec
      14.


PMID- 22177845
OWN - NLM
STAT- MEDLINE
DCOM- 20120612
LR  - 20161021
IS  - 1578-6749 (Electronic)
IS  - 0210-5691 (Linking)
VI  - 36
IP  - 1
DP  - 2012 Jan-Feb
TI  - [Preliminary experience with the introduction of life-sustaining treatment
      limitation in the electronic clinical record].
PG  - 32-6
LID - 10.1016/j.medin.2011.09.012 [doi]
AB  - Life-sustaining treatment limitation (LSTL) is an increasingly common practice.
      However, its application is sometimes not clearly reflected in the clinical
      record-this giving rise to the adoption of measures that could have been avoided,
      including admission to the intensive care unit (ICU), with the suffering and
      economical costs this implies. One way to trace patients subjected to LSTL is
      through an electronic registry allowing identification at all times of these
      individuals, and of the therapies that have been restricted in each case. The
      Ethics Committee of our center has developed a tool allowing the identification
      of patients subjected to LSTL and of the level of intervention required, and
      offering the association of a patient comfort management protocol.
CI  - Copyright (c) 2011 Elsevier Espana, S.L. and SEMICYUC. All rights reserved.
FAU - Poyo-Guerrero, R
AU  - Poyo-Guerrero R
AD  - Unidad de Cuidados Intensivos, Hospital Son Llatzer, Palma de Mallorca, Espana.
      rpoyoguerrero@hsll.es
FAU - Cruz, A
AU  - Cruz A
FAU - Laguna, M
AU  - Laguna M
FAU - Mata, J
AU  - Mata J
CN  - Comite de Etica del Hospital Son Llatzer de Palma de Mallorca (Espana)
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Experiencia preliminar en la introduccion de la limitacion de terapias de soporte
      vital en la historia clinica electronica.
DEP - 20111215
PL  - Spain
TA  - Med Intensiva
JT  - Medicina intensiva
JID - 9207689
RN  - 0 (Hypnotics and Sedatives)
RN  - 0 (Narcotics)
SB  - IM
MH  - Critical Care/*ethics/organization & administration
MH  - *Electronic Health Records
MH  - *Hospital Records
MH  - Humans
MH  - Hypnotics and Sedatives/therapeutic use
MH  - Informed Consent
MH  - Intensive Care Units/organization & administration
MH  - *Life Support Care/ethics
MH  - *Medical Futility
MH  - Mental Competency
MH  - Narcotics/therapeutic use
MH  - Palliative Care
MH  - Patient Selection
MH  - *Refusal to Treat/ethics
MH  - Resuscitation Orders
MH  - Spain
MH  - *Terminal Care/ethics/organization & administration
MH  - Treatment Refusal
MH  - Unnecessary Procedures
EDAT- 2011/12/20 06:00
MHDA- 2012/06/13 06:00
CRDT- 2011/12/20 06:00
PHST- 2011/06/20 00:00 [received]
PHST- 2011/09/27 00:00 [revised]
PHST- 2011/09/27 00:00 [accepted]
PHST- 2011/12/20 06:00 [entrez]
PHST- 2011/12/20 06:00 [pubmed]
PHST- 2012/06/13 06:00 [medline]
AID - S0210-5691(11)00299-3 [pii]
AID - 10.1016/j.medin.2011.09.012 [doi]
PST - ppublish
SO  - Med Intensiva. 2012 Jan-Feb;36(1):32-6. doi: 10.1016/j.medin.2011.09.012. Epub
      2011 Dec 15.


PMID- 22177581
OWN - NLM
STAT- MEDLINE
DCOM- 20120501
LR  - 20211021
IS  - 1476-5616 (Electronic)
IS  - 0033-3506 (Linking)
VI  - 126
IP  - 2
DP  - 2012 Feb
TI  - Identifying infants at risk of becoming obese: can we and should we?
PG  - 123-8
LID - 10.1016/j.puhe.2011.10.008 [doi]
AB  - OBJECTIVES: Increased understanding of the risk factors for childhood obesity has
      raised the possibility of identifying infants who are at risk of becoming
      overweight or obese, enabling early intervention for infants at high risk. This
      paper considers the known risk factors, describes statistical work aimed at
      identifying risk, and considers the ethical and practical issues of such a
      development. STUDY DESIGN AND METHODS: An overview of the published evidence for 
      risk factors in the early development of overweight and obesity, and a
      statistical assessment of the practicality of developing a simple obesity risk
      assessment tool (ORT) for use in the primary care setting. RESULTS: Analysis of
      data from two currently available UK birth cohort studies suggests that an ORT
      based on these data does not provide acceptable levels of specificity and
      sensitivity for use in a primary care setting. CONCLUSION: Further development of
      an ORT using additional data and enhanced statistical analysis may lead to a
      practical tool. However the practical, ethical and legal issues involved in its
      use, and the public health policy considerations that follow must be resolved.
CI  - Copyright (c) 2011 The Royal Society for Public Health. Published by Elsevier
      Ltd. All rights reserved.
FAU - Levine, R S
AU  - Levine RS
AD  - Academic Department of Paediatrics, University of Leeds, Leeds, UK.
      r.s.levine@leeds.ac.uk
FAU - Dahly, D L
AU  - Dahly DL
FAU - Rudolf, M C J
AU  - Rudolf MC
LA  - eng
GR  - G0902101/MRC_/Medical Research Council/United Kingdom
GR  - DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111215
PL  - Netherlands
TA  - Public Health
JT  - Public health
JID - 0376507
SB  - IM
CIN - Public Health. 2012 Feb;126(2):85-6. PMID: 22310468
MH  - Adult
MH  - Cohort Studies
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Obesity/*epidemiology
MH  - Overweight/epidemiology
MH  - Primary Health Care
MH  - Risk Assessment/*methods
MH  - Risk Factors
MH  - Sensitivity and Specificity
MH  - United Kingdom
EDAT- 2011/12/20 06:00
MHDA- 2012/05/02 06:00
CRDT- 2011/12/20 06:00
PHST- 2011/01/28 00:00 [received]
PHST- 2011/08/10 00:00 [revised]
PHST- 2011/10/28 00:00 [accepted]
PHST- 2011/12/20 06:00 [entrez]
PHST- 2011/12/20 06:00 [pubmed]
PHST- 2012/05/02 06:00 [medline]
AID - S0033-3506(11)00332-5 [pii]
AID - 10.1016/j.puhe.2011.10.008 [doi]
PST - ppublish
SO  - Public Health. 2012 Feb;126(2):123-8. doi: 10.1016/j.puhe.2011.10.008. Epub 2011 
      Dec 15.


PMID- 22177365
OWN - NLM
STAT- MEDLINE
DCOM- 20120703
LR  - 20211021
IS  - 1747-5341 (Electronic)
IS  - 1747-5341 (Linking)
VI  - 6
DP  - 2011 Dec 16
TI  - Epistemological and ethical assessment of obesity bias in industrialized
      countries.
PG  - 16
LID - 10.1186/1747-5341-6-16 [doi]
AB  - Bernard Lonergan's cognitive theory challenges us to raise questions about both
      the cognitive process through which obesity is perceived as a behaviour change
      issue and the objectivity of such a moral judgment. Lonergan's theory provides
      the theoretical tools to affirm that anti-fat discrimination, in the United
      States of America and in many industrialized countries, is the result of both a
      group bias that resists insights into the good of other groups and a general bias
      of anti-intellectualism that tends to set common sense against insights that
      require any thorough scientific analyses. While general bias diverts the public's
      attention away from the true aetiology of obesity, group bias sustains an
      anti-fat culture that subtly legitimates discriminatory practices and policies
      against obese people. Although anti-discrimination laws may seem to be a
      reasonable way of protecting obese and overweight individuals from
      discrimination, obesity bias can be best addressed by reframing the obesity
      debate from an environmental perspective from which tools and strategies to
      address both the social and individual determinants of obesity can be developed. 
      Attention should not be concentrated on individuals' behaviour as it is related
      to lifestyle choices, without giving due consideration to the all-encompassing
      constraining factors which challenge the social and rational blindness of obesity
      bias.
FAU - Azetsop, Jacquineau
AU  - Azetsop J
AD  - Departement de Sante Publique, Faculte des Sciences de la Sante de l'Universite
      de N'djamena, Avenue Mobutu, B.P. 1117 N'djamena, Tchad. maishaze@yahoo.com
FAU - Joy, Tisha R
AU  - Joy TR
LA  - eng
PT  - Journal Article
DEP - 20111216
PL  - England
TA  - Philos Ethics Humanit Med
JT  - Philosophy, ethics, and humanities in medicine : PEHM
JID - 101258058
SB  - IM
MH  - Culture
MH  - *Developed Countries
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Judgment/*ethics
MH  - Male
MH  - Models, Theoretical
MH  - *Obesity
MH  - *Prejudice
PMC - PMC3292805
EDAT- 2011/12/20 06:00
MHDA- 2012/07/04 06:00
CRDT- 2011/12/20 06:00
PHST- 2010/12/02 00:00 [received]
PHST- 2011/12/16 00:00 [accepted]
PHST- 2011/12/20 06:00 [entrez]
PHST- 2011/12/20 06:00 [pubmed]
PHST- 2012/07/04 06:00 [medline]
AID - 1747-5341-6-16 [pii]
AID - 10.1186/1747-5341-6-16 [doi]
PST - epublish
SO  - Philos Ethics Humanit Med. 2011 Dec 16;6:16. doi: 10.1186/1747-5341-6-16.


PMID- 22176925
OWN - NLM
STAT- MEDLINE
DCOM- 20120626
LR  - 20211021
IS  - 1600-6143 (Electronic)
IS  - 1600-6135 (Linking)
VI  - 12
IP  - 2
DP  - 2012 Feb
TI  - Incentives for organ donation: proposed standards for an internationally
      acceptable system.
PG  - 306-12
LID - 10.1111/j.1600-6143.2011.03881.x [doi]
AB  - Incentives for organ donation, currently prohibited in most countries, may
      increase donation and save lives. Discussion of incentives has focused on two
      areas: (1) whether or not there are ethical principles that justify the current
      prohibition and (2) whether incentives would do more good than harm. We herein
      address the second concern and propose for discussion standards and guidelines
      for an acceptable system of incentives for donation. We believe that if systems
      based on these guidelines were developed, harms would be no greater than those to
      today's conventional donors. Ultimately, until there are trials of incentives,
      the question of benefits and harms cannot be satisfactorily answered.
CI  - (c) 2011 The American Society of Transplantation and the American Society of
      Transplant Surgeons.
CN  - Working Group on Incentives for Living Donation
FAU - Matas, Arthur J
AU  - Matas AJ
FAU - Satel, Sally
AU  - Satel S
FAU - Munn, Stephen
AU  - Munn S
FAU - Richards, Janet Radcliffe
AU  - Richards JR
FAU - Tan-Alora, Angeles
AU  - Tan-Alora A
FAU - Ambagtsheer, Frederike J A E
AU  - Ambagtsheer FJ
FAU - Asis, Micheal D H
AU  - Asis MD
FAU - Baloloy, Leo
AU  - Baloloy L
FAU - Cole, Edward
AU  - Cole E
FAU - Crippin, Jeff
AU  - Crippin J
FAU - Cronin, David
AU  - Cronin D
FAU - Daar, Abdallah S
AU  - Daar AS
FAU - Eason, James
AU  - Eason J
FAU - Fine, Richard
AU  - Fine R
FAU - Florman, Sander
AU  - Florman S
FAU - Freeman, Richard
AU  - Freeman R
FAU - Fung, John
AU  - Fung J
FAU - Gaertner, Wulf
AU  - Gaertner W
FAU - Gaston, Robert
AU  - Gaston R
FAU - Ghahramani, Nasrollah
AU  - Ghahramani N
FAU - Ghods, Ahad
AU  - Ghods A
FAU - Goodwin, Michelle
AU  - Goodwin M
FAU - Gutmann, Thomas
AU  - Gutmann T
FAU - Hakim, Nadey
AU  - Hakim N
FAU - Hippen, Benjamin
AU  - Hippen B
FAU - Huilgol, Ajit
AU  - Huilgol A
FAU - Kam, Igal
AU  - Kam I
FAU - Lamban, Arlene
AU  - Lamban A
FAU - Land, Walter
AU  - Land W
FAU - Langnas, Alan
AU  - Langnas A
FAU - Lesaca, Reynaldo
AU  - Lesaca R
FAU - Levy, Gary
AU  - Levy G
FAU - Liquette, RoseMarie
AU  - Liquette R
FAU - Marks, William H
AU  - Marks WH
FAU - Miller, Charles
AU  - Miller C
FAU - Ona, Enrique
AU  - Ona E
FAU - Pamugas, Glenda
AU  - Pamugas G
FAU - Paraiso, Antonio
AU  - Paraiso A
FAU - Peters, Thomas G
AU  - Peters TG
FAU - Price, David
AU  - Price D
FAU - Randhawa, Gurch
AU  - Randhawa G
FAU - Reed, Alan
AU  - Reed A
FAU - Rigg, Keith
AU  - Rigg K
FAU - Serrano, Dennis
AU  - Serrano D
FAU - Sollinger, Hans
AU  - Sollinger H
FAU - Sundar, Sankaran
AU  - Sundar S
FAU - Teperman, Lewis
AU  - Teperman L
FAU - van Dijk, Gert
AU  - van Dijk G
FAU - Weimar, Willem
AU  - Weimar W
FAU - Danguilan, Romina
AU  - Danguilan R
LA  - eng
GR  - K23 DK084300/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20111217
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
SB  - IM
MH  - Humans
MH  - Motivation
MH  - Principle-Based Ethics
MH  - Tissue Donors/*ethics
MH  - Tissue and Organ Procurement/*ethics
PMC - PMC3350332
MID - NIHMS374761
EDAT- 2011/12/20 06:00
MHDA- 2012/06/27 06:00
CRDT- 2011/12/20 06:00
PHST- 2011/12/20 06:00 [entrez]
PHST- 2011/12/20 06:00 [pubmed]
PHST- 2012/06/27 06:00 [medline]
AID - 10.1111/j.1600-6143.2011.03881.x [doi]
PST - ppublish
SO  - Am J Transplant. 2012 Feb;12(2):306-12. doi: 10.1111/j.1600-6143.2011.03881.x.
      Epub 2011 Dec 17.


PMID- 22176816
OWN - NLM
STAT- MEDLINE
DCOM- 20120329
LR  - 20211021
IS  - 1742-4755 (Electronic)
IS  - 1742-4755 (Linking)
VI  - 8
DP  - 2011 Dec 16
TI  - Psychosocial implications of tubal ligation in a rural health district: a
      phenomenological study.
PG  - 38
LID - 10.1186/1742-4755-8-38 [doi]
AB  - BACKGROUND: Tubal ligation is the most popular family planning method worldwide. 
      While its benefits, such as effectiveness in protecting against pregnancies,
      minimal need for long-term follow-up and low side-effects profile are well
      documented, it has many reported complications. However, to date, these
      complications have not been described by residents in Congo. Therefore, the study
      aimed at exploring the experience of women who had undergone tubal ligation,
      focusing on perceptions of physical, psychological and contextual experiences of 
      participants. METHODS: This qualitative study used a semi-structured
      questionnaire in a phenomenological paradigm to collect data. Fifteen
      participants were purposefully selected among sterilized women who had a ligation
      procedure performed, were aged between 30 and 40 years, and were living within
      the catchment area of the district hospital. Data were collected by two
      registered nurses, tape-recorded, and transcribed verbatim. Reading and
      re-reading cut and paste techniques, and integration were used to establish
      codes, categories, themes, and description. RESULTS: Diverse and sometimes
      opposite changes in somatic symptoms, psychological symptoms, productivity,
      ecological relationships, doctor-client relationships, ethical issues, and change
      of life style were the major problem domains. CONCLUSIONS: Clients reported
      conflicting experiences in several areas of their lives after tubal
      sterilization. Management, including awareness of the particular features of the 
      client, is needed to decrease the likelihood of psychosocial morbidity and/or to 
      select clients in need of sterilization.
FAU - Lutala, Prosper M
AU  - Lutala PM
AD  - Department of Family Medecine, Universite de Goma, Goma, 2 Avenue Himbi, Congo
      P,O, Box 204 Goma, Congo. mukobelwalutalap@yahoo.com
FAU - Hugo, Jannie F
AU  - Hugo JF
FAU - Luhiriri, Levi N
AU  - Luhiriri LN
LA  - eng
PT  - Journal Article
DEP - 20111216
PL  - England
TA  - Reprod Health
JT  - Reproductive health
JID - 101224380
SB  - IM
MH  - Adult
MH  - *Attitude to Health
MH  - Congo
MH  - Developing Countries
MH  - Efficiency
MH  - Female
MH  - Guilt
MH  - Humans
MH  - Interpersonal Relations
MH  - Menstruation Disturbances/etiology
MH  - Pain/etiology
MH  - Patient Satisfaction
MH  - Physician-Patient Relations
MH  - Rural Health
MH  - Sterilization, Tubal/adverse effects/*psychology
PMC - PMC3269980
EDAT- 2011/12/20 06:00
MHDA- 2012/03/30 06:00
CRDT- 2011/12/20 06:00
PHST- 2011/10/22 00:00 [received]
PHST- 2011/12/16 00:00 [accepted]
PHST- 2011/12/20 06:00 [entrez]
PHST- 2011/12/20 06:00 [pubmed]
PHST- 2012/03/30 06:00 [medline]
AID - 1742-4755-8-38 [pii]
AID - 10.1186/1742-4755-8-38 [doi]
PST - epublish
SO  - Reprod Health. 2011 Dec 16;8:38. doi: 10.1186/1742-4755-8-38.


PMID- 22176693
OWN - NLM
STAT- MEDLINE
DCOM- 20120604
LR  - 20211203
IS  - 1751-7893 (Electronic)
IS  - 1751-7885 (Linking)
VI  - 6
IP  - 1
DP  - 2012 Feb
TI  - Translational and clinical research in Singapore: ethical issues in a
      longitudinal study of the prodromal phase of schizophrenia.
PG  - 3-10
LID - 10.1111/j.1751-7893.2011.00318.x [doi]
AB  - AIMS: This paper aims to provide an overview of the ethical issues that have been
      raised by The Longitudinal Youth at Risk Study, which is being led by the
      Institute of Mental Health in Singapore as part of a multi-centre and
      multinational study in translational and clinical research in psychosis. This
      project is designed to identify the biomarkers of the trajectory to psychosis. As
      well as providing insights into the psychopathology and psychophysiology of the
      disease, the study will prospectively identify those in the Singaporean
      population with an ultra-high risk of developing psychosis. The project will
      collect both observational and clinically relevant data from an at-risk group:
      adolescents and young adults. METHODS: A normative analysis was used to consider 
      the ethical issues that arise as a result of this study, its methods, sample
      population and clinical management policy. RESULTS: The project was found to
      raise particular and sensitive ethical and legal issues relating to the conduct
      of research with vulnerable populations who may be entering the prodromal phase
      of psychosis. Issues raised included notions of consent, privacy,
      confidentiality, stigmatization, duty of care and therapeutic misconception.
      CONCLUSION: Whereas some of the issues raised by this study present with
      manageable solutions, others may be justifiable within the cultural context of
      Singapore and warrant further discussion.
CI  - (c) 2011 Blackwell Publishing Asia Pty Ltd.
FAU - Lysaght, Tamra
AU  - Lysaght T
AD  - Institute of Mental Health, Early Psychosis Intervention, Buangkok Green, Medical
      Park, Singapore. tamra.lysaght@nuhs.edu.sg
FAU - Capps, Benjamin
AU  - Capps B
FAU - Subramaniam, Mythily
AU  - Subramaniam M
FAU - Chong, Siow-Ann
AU  - Chong SA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20111218
PL  - Australia
TA  - Early Interv Psychiatry
JT  - Early intervention in psychiatry
JID - 101320027
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Confidentiality/ethics
MH  - Early Diagnosis
MH  - Humans
MH  - Informed Consent/ethics
MH  - Longitudinal Studies/ethics
MH  - Schizophrenia/*diagnosis
MH  - Singapore
MH  - Stereotyping
MH  - Translational Research, Biomedical/*ethics
MH  - Vulnerable Populations/psychology
EDAT- 2011/12/20 06:00
MHDA- 2012/06/05 06:00
CRDT- 2011/12/20 06:00
PHST- 2011/12/20 06:00 [entrez]
PHST- 2011/12/20 06:00 [pubmed]
PHST- 2012/06/05 06:00 [medline]
AID - 10.1111/j.1751-7893.2011.00318.x [doi]
PST - ppublish
SO  - Early Interv Psychiatry. 2012 Feb;6(1):3-10. doi:
      10.1111/j.1751-7893.2011.00318.x. Epub 2011 Dec 18.


PMID- 22176673
OWN - NLM
STAT- MEDLINE
DCOM- 20120509
LR  - 20211021
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 12
DP  - 2011 Dec 16
TI  - Perspectives on the ethical concerns and justifications of the 2006 Centers for
      Disease Control and Prevention HIV testing recommendations.
PG  - 24
LID - 10.1186/1472-6939-12-24 [doi]
AB  - BACKGROUND: In 2006, the Centers for Disease Control and Prevention (CDC)
      recommended three changes to HIV testing methods in US healthcare settings: (1)
      an opt-out approach, (2) removal of separate signed consent, and (3) optional HIV
      prevention counseling. These recommendations led to a public debate about their
      moral acceptability. METHODS: We interviewed 25 members from the fields of US HIV
      advocacy, care, policy, and research about the ethical merits and demerits of the
      three changes to HIV testing methods. We performed a qualitative analysis of the 
      participant responses in the interviews and summarized the major themes. RESULTS:
      In general, arguments in favor of the methods were based upon their ultimate
      contribution to increasing HIV testing and permitting the consequent benefits of 
      identifying those who are HIV infected and linking them to further care.
      CONCLUSIONS: The prevailing theme of ethical concern focused on suspicions that
      the methods might not be properly implemented, and that further safeguards might 
      be needed.
FAU - Waxman, Michael J
AU  - Waxman MJ
AD  - Department of Emergency Medicine, Alpert Medical School of Brown University, 593 
      Eddy Street, Providence, Rhode Island 02912, USA. mwaxman@hotmail.com
FAU - Merchant, Roland C
AU  - Merchant RC
FAU - Celada, M Teresa
AU  - Celada MT
FAU - Clark, Melissa A
AU  - Clark MA
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20111216
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - AIDS Serodiagnosis/*ethics
MH  - *Centers for Disease Control and Prevention, U.S.
MH  - *Counseling
MH  - HIV Infections/*diagnosis/*prevention & control/transmission
MH  - Health Policy/trends
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Interviews as Topic
MH  - *Moral Obligations
MH  - Patient Rights
MH  - Practice Guidelines as Topic
MH  - Primary Prevention
MH  - Qualitative Research
MH  - Risk Reduction Behavior
MH  - Surveys and Questionnaires
MH  - United States
PMC - PMC3322346
EDAT- 2011/12/20 06:00
MHDA- 2012/05/10 06:00
CRDT- 2011/12/20 06:00
PHST- 2011/09/09 00:00 [received]
PHST- 2011/12/16 00:00 [accepted]
PHST- 2011/12/20 06:00 [entrez]
PHST- 2011/12/20 06:00 [pubmed]
PHST- 2012/05/10 06:00 [medline]
AID - 1472-6939-12-24 [pii]
AID - 10.1186/1472-6939-12-24 [doi]
PST - epublish
SO  - BMC Med Ethics. 2011 Dec 16;12:24. doi: 10.1186/1472-6939-12-24.


PMID- 22176517
OWN - NLM
STAT- MEDLINE
DCOM- 20120906
LR  - 20220409
IS  - 1600-0447 (Electronic)
IS  - 0001-690X (Linking)
VI  - 125
IP  - 6
DP  - 2012 Jun
TI  - Patient characteristics and symptoms associated with perceived coercion during
      hospital treatment.
PG  - 460-7
LID - 10.1111/j.1600-0447.2011.01809.x [doi]
AB  - OBJECTIVE: Large numbers of psychiatric patients either are involuntarily
      admitted to hospital treatment or feel coerced despite a legally voluntary
      admission. For ethical and clinical reasons, their perceived coercion should be
      reduced as far as possible. There is however limited evidence on patient
      characteristics associated with perceived coercion during hospital treatment.
      This study aimed to identify i) sociodemographic and clinical characteristics
      associated with perceived coercion at admission and ii) changes in symptoms and
      global functioning associated with changes in perceived coercion over time.
      METHOD: Three thousand and ninety three in-patients who were involuntarily
      admitted or felt coerced to hospital treatment despite a legally voluntary
      admission were recruited in the European evaluation of coercion in psychiatry and
      harmonization of best clinical practice - EUNOMIA project in 11 European
      countries. Perceived coercion, global functioning and symptoms were assessed
      after admission and at a 3-month follow-up. RESULTS: Involuntary admission,
      female gender, poorer global functioning and more positive symptoms were
      associated with higher levels of perceived coercion at admission. Perceived
      coercion significantly decreased over time, and the improvements in global
      functioning and positive symptoms were associated with reduction in perceived
      coercion. CONCLUSION: Female patients perceive more coercion in psychiatric
      hospital treatment. Effective treatment for positive symptoms and improving
      patients' global functioning may lead to a reduction in perceived coercion.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Fiorillo, A
AU  - Fiorillo A
AD  - Department of Psychiatry, University of Naples SUN, Largo Madonna delle Grazie,
      Italy. andrea.fiorillo@unina2.it
FAU - Giacco, D
AU  - Giacco D
FAU - De Rosa, C
AU  - De Rosa C
FAU - Kallert, T
AU  - Kallert T
FAU - Katsakou, C
AU  - Katsakou C
FAU - Onchev, G
AU  - Onchev G
FAU - Raboch, J
AU  - Raboch J
FAU - Mastrogianni, A
AU  - Mastrogianni A
FAU - Del Vecchio, V
AU  - Del Vecchio V
FAU - Luciano, M
AU  - Luciano M
FAU - Catapano, F
AU  - Catapano F
FAU - Dembinskas, A
AU  - Dembinskas A
FAU - Nawka, P
AU  - Nawka P
FAU - Kiejna, A
AU  - Kiejna A
FAU - Torres-Gonzales, F
AU  - Torres-Gonzales F
FAU - Kjellin, L
AU  - Kjellin L
FAU - Maj, M
AU  - Maj M
FAU - Priebe, S
AU  - Priebe S
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20111216
PL  - United States
TA  - Acta Psychiatr Scand
JT  - Acta psychiatrica Scandinavica
JID - 0370364
SB  - IM
MH  - Adult
MH  - *Coercion
MH  - Cohort Studies
MH  - *Commitment of Mentally Ill
MH  - Europe
MH  - Female
MH  - Follow-Up Studies
MH  - *Hospitals, Psychiatric
MH  - Humans
MH  - Inpatients/psychology
MH  - Male
MH  - Middle Aged
MH  - *Patient Admission
MH  - Perception
MH  - Prospective Studies
MH  - Sex Factors
EDAT- 2011/12/20 06:00
MHDA- 2012/09/07 06:00
CRDT- 2011/12/20 06:00
PHST- 2011/12/20 06:00 [entrez]
PHST- 2011/12/20 06:00 [pubmed]
PHST- 2012/09/07 06:00 [medline]
AID - 10.1111/j.1600-0447.2011.01809.x [doi]
PST - ppublish
SO  - Acta Psychiatr Scand. 2012 Jun;125(6):460-7. doi:
      10.1111/j.1600-0447.2011.01809.x. Epub 2011 Dec 16.


PMID- 22175514
OWN - NLM
STAT- MEDLINE
DCOM- 20120417
LR  - 20181201
IS  - 1557-8577 (Electronic)
IS  - 1549-1684 (Linking)
VI  - 14
IP  - 6
DP  - 2011 Dec
TI  - Steady advance of stem cell therapies: report from the 2011 World Stem Cell
      Summit, Pasadena, California, October 3-5.
PG  - 699-704
LID - 10.1089/rej.2011.1292 [doi]
AB  - Stem cell research and related therapies (including regenerative medicine and
      cellular therapies) could have a significant near-term impact on worldwide public
      health and aging. One reason is the industry's strong linkage between policy,
      science, industry, and patient advocacy, as was clear in the attendance and
      programming at the 7(th) annual World Stem Cell Summit held in Pasadena,
      California, October 3-5, 2011. A special conference session sponsored by the SENS
      Foundation discussed how stem cell therapies are being used to extend healthy
      life span. Stem cells are useful not only in cell-replacement therapies, but also
      in disease modeling, drug discovery, and drug toxicity screening. Stem cell
      therapies are currently being applied to over 50 diseases, including heart, lung,
      neurodegenerative, and eye disease, cancer, and human immunodeficiency virus
      (HIV)/acquired immunodeficiency syndrome (AIDS). Dozens of companies are
      developing therapeutic solutions that are in different stages of clinical use and
      clinical trials. Some high-profile therapies include Dendreon's Provenge for
      prostate cancer, Geron's first-ever embryonic stem cell trials for spinal cord
      injury, Fibrocell's laViv cellular therapy for wrinkles, and well-established
      commercial skin substitutes (Organogenesis' Apligraf and Advanced BioHealing's
      Dermagraft). Stem cell policy issues under consideration include medical tourism,
      standards for large-scale stem cell manufacturing, and lingering ethical debates 
      over the use of embryonic stem cells. Contemporary stem cell science advances
      include a focus on techniques for the direct reprogramming of cells from one
      lineage to another without returning to pluripotency as an intermediary step,
      improved means of generating and characterizing induced pluripotent cells, and
      progress in approaches to neurodegenerative disease.
FAU - Swan, Melanie
AU  - Swan M
AD  - MS Futures Group, P.O. Box 61258, Palo Alto, CA 94306, USA. m@melanieswan.com
LA  - eng
PT  - Congress
PL  - United States
TA  - Rejuvenation Res
JT  - Rejuvenation research
JID - 101213381
SB  - IM
MH  - Aging
MH  - California
MH  - Cell Culture Techniques
MH  - Cell- and Tissue-Based Therapy/*methods
MH  - Drug Design
MH  - HIV Infections/therapy
MH  - Humans
MH  - Longevity
MH  - Neoplasms/therapy
MH  - Neurodegenerative Diseases/*therapy
MH  - Public Health
MH  - Regenerative Medicine/methods
MH  - Spinal Cord Injuries/therapy
MH  - Stem Cell Transplantation/*methods
EDAT- 2011/12/20 06:00
MHDA- 2012/04/18 06:00
CRDT- 2011/12/20 06:00
PHST- 2011/12/20 06:00 [entrez]
PHST- 2011/12/20 06:00 [pubmed]
PHST- 2012/04/18 06:00 [medline]
AID - 10.1089/rej.2011.1292 [doi]
PST - ppublish
SO  - Rejuvenation Res. 2011 Dec;14(6):699-704. doi: 10.1089/rej.2011.1292.


PMID- 22175095
OWN - HMD
STAT- MEDLINE
DCOM- 20121002
LR  - 20191112
IS  - 0094-0798 (Print)
IS  - 0094-0798 (Linking)
VI  - 38
IP  - 2
DP  - 2011
TI  - The limits of oral history: ethics and methodology amid highly politicized
      research settings.
PG  - 287-307
AB  - In recent years, oral history has been celebrated by its practitioners for its
      humanizing potential, and its ability to democratize history by bringing the
      narratives of people and communities typically absent in the archives into
      conversation with that of the political and intellectual elites who generally
      write history. And when dealing with the narratives of ordinary people living in 
      conditions of social and political stability, the value of oral history is
      unquestionable. However, in recent years, oral historians have increasingly
      expanded their gaze to consider intimate accounts of extreme human experiences,
      such as narratives of survival and flight in response to mass atrocities. This
      shift in academic and practical interests begs the questions: Are there limits to
      oral historical methods and theory? And if so, what are these limits? This paper 
      begins to address these questions by drawing upon fourteen months of fieldwork in
      Rwanda and Bosnia-Hercegovina, during which I conducted multiple life history
      interviews with approximately one hundred survivors, ex-combatants, and
      perpetrators of genocide and related mass atrocities. I argue that there are
      limits to the application of oral history, particularly when working amid highly 
      politicized research settings.
FAU - Jessee, Erin
AU  - Jessee E
AD  - Carleton Univ., Ottawa.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - Oral Hist Rev
JT  - The Oral history review
JID - 7901558
MH  - Bosnia and Herzegovina/ethnology
MH  - Criminals/education/history/legislation & jurisprudence/psychology
MH  - *Empirical Research
MH  - *Ethics/history
MH  - History, 20th Century
MH  - History, 21st Century
MH  - *Homicide/economics/ethnology/history/legislation & jurisprudence/psychology
MH  - Human Rights Abuses/economics/ethnology/history/legislation &
      jurisprudence/psychology
MH  - *Interviews as Topic
MH  - Military Personnel/education/history/legislation & jurisprudence/psychology
MH  - Rwanda/ethnology
MH  - *Survivors/history/legislation & jurisprudence/psychology
MH  - *Violence/economics/ethnology/history/legislation & jurisprudence/psychology
EDAT- 2011/12/20 06:00
MHDA- 2012/10/04 06:00
CRDT- 2011/12/20 06:00
PHST- 2011/12/20 06:00 [entrez]
PHST- 2011/12/20 06:00 [pubmed]
PHST- 2012/10/04 06:00 [medline]
AID - 10.1093/ohr/ohr098 [doi]
PST - ppublish
SO  - Oral Hist Rev. 2011;38(2):287-307. doi: 10.1093/ohr/ohr098.


PMID- 24520527
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20211021
IS  - 2220-315X (Print)
IS  - 2220-315X (Linking)
VI  - 1
IP  - 1
DP  - 2011 Dec 20
TI  - A short perspective on gene therapy: Clinical experience on gene therapy of
      gliomablastoma multiforme.
PG  - 10-6
LID - 10.5493/wjem.v1.i1.10 [doi]
AB  - More than two decades have passed since the first gene therapy clinical trial was
      conducted. During this time, we have gained much knowledge regarding gene therapy
      in general, but also learned to understand the fear that persists in society. We 
      have experienced drawbacks and successes. More than 1700 clinical trials have
      been conducted where gene therapy is used as a means for therapy. In the very
      first trial, patients with advanced melanoma were treated with tumor infiltrating
      lymphocytes genetically modified ex-vivo to express tumor necrosis factor. Around
      the same time the first gene therapy trial was conducted, the ethical aspects of 
      performing gene therapy on humans was intensively discussed. What are the risks
      involved with gene therapy? Can we control the technology? What is ethically
      acceptable and what are the indications gene therapy can be used for? Initially, 
      gene therapy was thought to be implemented mainly for the treatment of
      monogenetic diseases, such as adenosine deaminase deficiency. However, other
      therapeutic areas have become of interest and currently cancer is the most
      studied therapeutic area for gene therapy based medicines. In this review I will 
      be giving a short introduction into gene therapy and will direct the discussion
      to where we should go from here. Furthermore, I will focus on the use of the
      Herpes simplex virus-thymidine kinase for gene therapy of malignant gliomas and
      highlight the efficacy of gene therapy for the treatment of malignant gliomas,
      but other strategies will also be mentioned.
FAU - Wirth, Thomas
AU  - Wirth T
AD  - Thomas Wirth, AI Virtanen Institute, Department of Biotechnology and Molecular
      Medicine, University of Eastern Finland, Neulaniementie 2, FIN-70211 Kuopio,
      Finland.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111220
PL  - United States
TA  - World J Exp Med
JT  - World journal of experimental medicine
JID - 101618808
PMC - PMC3905579
OTO - NOTNLM
OT  - Gene therapy
OT  - Glioblastoma multiforme
OT  - Herpes simplex virus - thymidine kinase
EDAT- 2011/12/20 00:00
MHDA- 2011/12/20 00:01
CRDT- 2014/02/13 06:00
PHST- 2011/10/24 00:00 [received]
PHST- 2011/12/12 00:00 [revised]
PHST- 2011/12/16 00:00 [accepted]
PHST- 2014/02/13 06:00 [entrez]
PHST- 2011/12/20 00:00 [pubmed]
PHST- 2011/12/20 00:01 [medline]
AID - 10.5493/wjem.v1.i1.10 [doi]
PST - epublish
SO  - World J Exp Med. 2011 Dec 20;1(1):10-6. doi: 10.5493/wjem.v1.i1.10. eCollection
      2011 Dec 20.


PMID- 23526839
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 0029-3105 (Print)
IS  - 0029-3105 (Linking)
VI  - 62
IP  - 4
DP  - 2011 Dec 20
TI  - What Help is a Steward? Stewardship, Political Theory, and Public Health Law and 
      Ethics.
PG  - 599-616
FAU - Coggon, John
AU  - Coggon J
AD  - Institute for Science, Ethics, and Innovation, School of Law, University of
      Manchester John.Coggon@manchester.ac.uk .
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - 087439/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PL  - Northern Ireland
TA  - North Irel Leg Q
JT  - The Northern Ireland legal quarterly
JID - 100972651
PMC - PMC3605915
MID - EMS50899
EDAT- 2011/12/20 00:00
MHDA- 2011/12/20 00:01
CRDT- 2013/03/26 06:00
PHST- 2013/03/26 06:00 [entrez]
PHST- 2011/12/20 00:00 [pubmed]
PHST- 2011/12/20 00:01 [medline]
PST - ppublish
SO  - North Irel Leg Q. 2011 Dec 20;62(4):599-616.


PMID- 22174982
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 2090-0015 (Electronic)
IS  - 2090-0007 (Linking)
VI  - 2011
DP  - 2011
TI  - Risk assessment and management for medically complex potential living kidney
      donors: a few deontological criteria and ethical values.
PG  - 307130
LID - 10.1155/2011/307130 [doi]
AB  - A SOUND EVALUATION OF EVERY BIOETHICAL PROBLEM SHOULD BE PREDICATED ON A CAREFUL 
      ANALYSIS OF AT LEAST TWO BASIC ELEMENTS: (i) reliable scientific information and 
      (ii) the ethical principles and values at stake. A thorough evaluation of both
      elements also calls for a careful examination of statements by authoritative
      institutions. Unfortunately, in the case of medically complex living donors
      neither element gives clear-cut answers to the ethical problems raised. Likewise,
      institutionary documents frequently offer only general criteria, which are not
      very helpful when making practical choices. This paper first introduces a brief
      overview of scientific information, ethical values, and institutionary documents;
      the notions of "acceptable risk" and "minimal risk" are then briefly examined,
      with reference to the problem of medically complex living donors. The so-called
      precautionary principle and the value of solidarity are then discussed as
      offering a possible approach to the ethical problem of medically complex living
      donors.
FAU - Petrini, Carlo
AU  - Petrini C
AD  - Bioethics Unit, Istituto Superiore di Sanita, Via Giano della Bella 34, 00162
      Roma, Italy.
LA  - eng
PT  - Journal Article
DEP - 20111207
PL  - United States
TA  - J Transplant
JT  - Journal of transplantation
JID - 101519118
PMC - PMC3235912
EDAT- 2011/12/17 06:00
MHDA- 2011/12/17 06:01
CRDT- 2011/12/17 06:00
PHST- 2011/08/17 00:00 [received]
PHST- 2011/10/24 00:00 [accepted]
PHST- 2011/12/17 06:00 [entrez]
PHST- 2011/12/17 06:00 [pubmed]
PHST- 2011/12/17 06:01 [medline]
AID - 10.1155/2011/307130 [doi]
PST - ppublish
SO  - J Transplant. 2011;2011:307130. doi: 10.1155/2011/307130. Epub 2011 Dec 7.


PMID- 22174914
OWN - NLM
STAT- MEDLINE
DCOM- 20120423
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 6
IP  - 12
DP  - 2011
TI  - Generation of stratified squamous epithelial progenitor cells from mouse induced 
      pluripotent stem cells.
PG  - e28856
LID - 10.1371/journal.pone.0028856 [doi]
AB  - BACKGROUND: Application of induced pluripotent stem (iPS) cells in regenerative
      medicine will bypass ethical issues associated with use of embryonic stem cells. 
      In addition, patient-specific IPS cells can be useful to elucidate the
      pathophysiology of genetic disorders, drug screening, and tailor-made medicine.
      However, in order to apply iPS cells to mitotic tissue, induction of tissue stem 
      cells that give rise to progeny of the target organ is required.
      METHODOLOGY/PRINCIPAL FINDINGS: We induced stratified epithelial cells from mouse
      iPS cells by co-culture with PA6 feeder cells (SDIA-method) with use of BMP4.
      Clusters of cells positive for the differentiation markers KRT1 or KRT12 were
      observed in KRT14-positive colonies. We successfully cloned KRT14 and p63
      double-positive stratified epithelial progenitor cells from iPS-derived
      epithelial cells, which formed stratified epithelial sheets consisting of five-
      to six-polarized epithelial cells in vitro. When these clonal cells were cultured
      on denuded mouse corneas, a robust stratified epithelial layer was observed with 
      physiological cell polarity including high levels of E-cadherin, p63 and K15
      expression in the basal layer and ZO-1 in the superficial layer, recapitulating
      the apico-basal polarity of the epithelium in vivo. CONCLUSIONS/SIGNIFICANCE:
      These results suggest that KRT14 and p63 double-positive epithelial progenitor
      cells can be cloned from iPS cells in order to produce polarized multilayer
      epithelial cell sheets.
FAU - Yoshida, Satoru
AU  - Yoshida S
AD  - Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
FAU - Yasuda, Miyuki
AU  - Yasuda M
FAU - Miyashita, Hideyuki
AU  - Miyashita H
FAU - Ogawa, Yoko
AU  - Ogawa Y
FAU - Yoshida, Tetsu
AU  - Yoshida T
FAU - Matsuzaki, Yumi
AU  - Matsuzaki Y
FAU - Tsubota, Kazuo
AU  - Tsubota K
FAU - Okano, Hideyuki
AU  - Okano H
FAU - Shimmura, Shigeto
AU  - Shimmura S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111209
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Bone Morphogenetic Protein 4)
SB  - IM
MH  - Animals
MH  - Bone Morphogenetic Protein 4/pharmacology
MH  - Cell Culture Techniques/*methods
MH  - Cell Differentiation/drug effects
MH  - Cell Proliferation/drug effects
MH  - Cells, Cultured
MH  - Clone Cells
MH  - Cornea/cytology
MH  - Epidermal Cells
MH  - Epidermis/drug effects/metabolism
MH  - Epithelial Cells/*cytology/drug effects/ultrastructure
MH  - Induced Pluripotent Stem Cells/*cytology/drug effects/metabolism
MH  - Mice
MH  - Stem Cells/*cytology/drug effects/metabolism
MH  - Time Factors
MH  - Tissue Engineering
PMC - PMC3235161
EDAT- 2011/12/17 06:00
MHDA- 2012/04/24 06:00
CRDT- 2011/12/17 06:00
PHST- 2011/07/12 00:00 [received]
PHST- 2011/11/16 00:00 [accepted]
PHST- 2011/12/17 06:00 [entrez]
PHST- 2011/12/17 06:00 [pubmed]
PHST- 2012/04/24 06:00 [medline]
AID - 10.1371/journal.pone.0028856 [doi]
AID - PONE-D-11-13236 [pii]
PST - ppublish
SO  - PLoS One. 2011;6(12):e28856. doi: 10.1371/journal.pone.0028856. Epub 2011 Dec 9.


PMID- 22174893
OWN - NLM
STAT- MEDLINE
DCOM- 20120423
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 6
IP  - 12
DP  - 2011
TI  - The ethics police?: IRBs' views concerning their power.
PG  - e28773
LID - 10.1371/journal.pone.0028773 [doi]
AB  - BACKGROUND: In recent years, tensions between IRBs and principal investigators
      (PIs) have risen, posing the needs to understand these conflicts, their
      underlying causes, and possible solutions. Researchers frequently complain about 
      IRBs, but how IRBs perceive and respond to these criticisms is unclear. METHODS: 
      I conducted in-depth, semi-structured interviews of two hours each with 46
      chairs, administrators, and members. I contacted the leadership of 60 IRBs around
      the country (every fourth one in the list of the top 240 institutions by NIH
      funding) and interviewed IRB leaders from 34 of these institutions (response rate
      = 55%). RESULTS: Interviewees suggest that IRBs and PIs may view the nature and
      causes of these conflicts very differently and misunderstand each other,
      exacerbating tensions. Interviewees often recognized that they were seen by PIs
      as having power, but many IRBs saw themselves as not having it (e.g., because
      they are "merely following the regulations," and their process is "open,"
      impersonal and unbiased, and they are themselves subject to higher administrative
      agencies), or as having it, but feeling it is small, and/or justified (e.g.,
      because it is based on overriding goals and "the community values," and IRBs are 
      trying to help PIs). Questions emerge as to whether IRBs do or should have power,
      and if so, what kind, how much, and when. Several factors may affect these
      tensions. CONCLUSIONS: This study, the first to explore how IRBs perceive and
      understand conflicts and power relationships with PIs, suggests how IRBs and PIs 
      may differ in viewing their respective roles and relationships, exacerbating
      tensions. These issues have critical implications for IRBs and PIs--to enhance
      their awareness and understanding of these conflicts (e.g., that IRBs may have
      discretionary power) and the underlying causes involved, and for increasing
      attention to research, practice, and policy concerning these areas of IRB
      functioning and interactions with PIs.
FAU - Klitzman, Robert
AU  - Klitzman R
AD  - Department of Psychiatry, Columbia University, New York, New York, United States 
      of America. RLK2@columbia.edu
LA  - eng
GR  - G13 LM009996/LM/NLM NIH HHS/United States
GR  - R01-NG04214/PHS HHS/United States
GR  - 5-G13-LM009996-02/LM/NLM NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20111213
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Ethics Committees, Research/*ethics
MH  - *Ethics, Research
MH  - Female
MH  - Humans
MH  - Male
MH  - *Power, Psychological
MH  - Research Personnel/ethics
MH  - Surveys and Questionnaires
PMC - PMC3236766
EDAT- 2011/12/17 06:00
MHDA- 2012/04/24 06:00
CRDT- 2011/12/17 06:00
PHST- 2011/07/29 00:00 [received]
PHST- 2011/11/15 00:00 [accepted]
PHST- 2011/12/17 06:00 [entrez]
PHST- 2011/12/17 06:00 [pubmed]
PHST- 2012/04/24 06:00 [medline]
AID - 10.1371/journal.pone.0028773 [doi]
AID - PONE-D-11-14776 [pii]
PST - ppublish
SO  - PLoS One. 2011;6(12):e28773. doi: 10.1371/journal.pone.0028773. Epub 2011 Dec 13.


PMID- 22174329
OWN - NLM
STAT- MEDLINE
DCOM- 20130104
LR  - 20161125
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 5
DP  - 2012 May
TI  - The gap between voluntary admission and detention in mental health units.
PG  - 281-5
LID - 10.1136/medethics-2011-100187 [doi]
AB  - This paper presents the case of a young man with a diagnosis of schizophrenia,
      who agreed to inpatient treatment primarily to avoid being formally detained. I
      draw on Peter Breggin's early critique of coercion of informal patients to supply
      an updated discussion of the ethical issues raised. Central questions are whether
      the admission was coercive, and if so, whether unethical. Whether or not
      involuntary admission would be justified, moral discomfort surrounds its
      appearance as a threat. This arises in part from ambivalence about autonomy:
      although a 'choice' is made, the threat of detention impinges on the patient's
      choice. Recent legal developments provide some experience of safeguarding those
      whose consent is not obtained. This highlights the lack of safeguards in this
      'gap' and suggests that we have the tools with which to begin to deal with the
      problem.
FAU - Bingham, Rachel
AU  - Bingham R
AD  - Amwell Group Practice, 4 Naoroji Street, London WC1X 0GB, UK.
      rachelbingham@nhs.net
LA  - eng
PT  - Journal Article
DEP - 20111214
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Choice Behavior
MH  - *Coercion
MH  - *Commitment of Mentally Ill/legislation & jurisprudence
MH  - Decision Making
MH  - Ethics, Medical
MH  - Hospital Units
MH  - Humans
MH  - Informed Consent
MH  - Legislation, Medical/ethics/standards/trends
MH  - *Mental Competency
MH  - *Mentally Ill Persons/psychology
MH  - *Patient Admission
MH  - Patient Discharge/legislation & jurisprudence
MH  - *Patient Rights/ethics/legislation & jurisprudence
MH  - Personal Autonomy
MH  - Psychiatry/*ethics/*legislation & jurisprudence
MH  - Schizophrenia/therapy
MH  - United Kingdom
EDAT- 2011/12/17 06:00
MHDA- 2013/01/05 06:00
CRDT- 2011/12/17 06:00
PHST- 2011/12/17 06:00 [entrez]
PHST- 2011/12/17 06:00 [pubmed]
PHST- 2013/01/05 06:00 [medline]
AID - medethics-2011-100187 [pii]
AID - 10.1136/medethics-2011-100187 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 May;38(5):281-5. doi: 10.1136/medethics-2011-100187. Epub 2011
      Dec 14.


PMID- 22173733
OWN - NLM
STAT- MEDLINE
DCOM- 20131213
LR  - 20130524
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 2
DP  - 2013 Jun
TI  - The necessary limits to temptation: the Turnkey Project.
PG  - 529-33
LID - 10.1007/s11948-011-9336-5 [doi]
AB  - In case of special engineering projects of important relevance it is interesting 
      to pay attention to several possible risks; some of them are in the field of
      morality or ethics. Due to the social importance of these risks, additional
      considerations or even additional warranties are justified.
FAU - Hernandez-Montes, Enrique
AU  - Hernandez-Montes E
AD  - School of Civil Engineering, University of Granada, Campus de Fuentenueva, 18072,
      Granada, Spain. emontes@ugr.es
FAU - Gil-Martin, Luisa Maria
AU  - Gil-Martin LM
FAU - Segura-Naya, Armando
AU  - Segura-Naya A
LA  - eng
PT  - Journal Article
DEP - 20111216
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Engineering/*ethics
MH  - Humans
MH  - *Morals
MH  - *Motivation
EDAT- 2011/12/17 06:00
MHDA- 2013/12/18 06:00
CRDT- 2011/12/17 06:00
PHST- 2011/07/05 00:00 [received]
PHST- 2011/11/24 00:00 [accepted]
PHST- 2011/12/17 06:00 [entrez]
PHST- 2011/12/17 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
AID - 10.1007/s11948-011-9336-5 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Jun;19(2):529-33. doi: 10.1007/s11948-011-9336-5. Epub 2011 
      Dec 16.


PMID- 22173478
OWN - NLM
STAT- MEDLINE
DCOM- 20120222
LR  - 20211021
IS  - 1474-1741 (Electronic)
IS  - 1474-1733 (Linking)
VI  - 12
IP  - 1
DP  - 2011 Dec 16
TI  - Vaccines targeting drugs of abuse: is the glass half-empty or half-full?
PG  - 67-72
LID - 10.1038/nri3130 [doi]
AB  - The advent of vaccines targeting drugs of abuse heralded a fundamentally
      different approach to treating substance-related disorders. In contrast to
      traditional pharmacotherapies for drug abuse, vaccines act by sequestering
      circulating drugs and terminating the drug-induced 'high' without inducing
      unwanted neuromodulatory effects. Drug-targeting vaccines have entered clinical
      evaluation, and although these vaccines show promise from a biomedical viewpoint,
      the ethical and socioeconomic implications of vaccinating patients against drugs 
      of abuse merit discussion within the scientific community.
FAU - Janda, Kim D
AU  - Janda KD
AD  - Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines
      Road, BCC 582, La Jolla, California 92037-1000, USA. kdjanda@scripps.edu
FAU - Treweek, Jennifer B
AU  - Treweek JB
LA  - eng
PT  - Review
DEP - 20111216
PL  - England
TA  - Nat Rev Immunol
JT  - Nature reviews. Immunology
JID - 101124169
RN  - 0 (Antibodies)
RN  - 0 (Vaccines)
SB  - IM
MH  - Animals
MH  - Antibodies/therapeutic use
MH  - Humans
MH  - Immunotherapy
MH  - Substance-Related Disorders/*drug therapy/immunology
MH  - Vaccines/*therapeutic use
EDAT- 2011/12/17 06:00
MHDA- 2012/02/23 06:00
CRDT- 2011/12/17 06:00
PHST- 2011/12/17 06:00 [entrez]
PHST- 2011/12/17 06:00 [pubmed]
PHST- 2012/02/23 06:00 [medline]
AID - nri3130 [pii]
AID - 10.1038/nri3130 [doi]
PST - epublish
SO  - Nat Rev Immunol. 2011 Dec 16;12(1):67-72. doi: 10.1038/nri3130.


PMID- 22173132
OWN - NLM
STAT- MEDLINE
DCOM- 20130503
LR  - 20220331
IS  - 1476-5543 (Electronic)
IS  - 0743-8346 (Linking)
VI  - 32
IP  - 11
DP  - 2012 Nov
TI  - Survey of neonatologists' attitudes toward limiting life-sustaining treatments in
      the neonatal intensive care unit.
PG  - 886-92
LID - 10.1038/jp.2011.186 [doi]
AB  - OBJECTIVE: To understand neonatologists' attitudes toward end-of-life (EOL)
      management in clinical scenarios, EOL ethical concepts and resource utilization. 
      STUDY DESIGN: American Academy of Pediatrics (AAP) Perinatal section members
      completed an anonymous online survey. Respondents indicated preferences in
      limiting life-sustaining treatments in four clinical scenarios, ranked agreement 
      with EOL-care ethics statements, indicated outside resources previously used and 
      provided demographic information. RESULT: In all, 451 surveys were analyzed.
      Across clinical scenarios and as general ethical concepts, withdrawal of
      mechanical ventilation in severely affected patients was most accepted by
      respondents; withdrawal of artificial nutrition and hydration was least accepted.
      One-third of neonatologists did not agree that non-initiation of treatment is
      ethically equivalent to withdrawal. Around 20% of neonatologists would not defer 
      care if uncomfortable with a parent's request. Respondents' resources included
      ethics committees, AAP guidelines and legal counsel/courts. CONCLUSION:
      Challenges to providing just, unified EOL care strategies are discussed,
      including deferring care, limiting artificial nutrition/hydration and conditions 
      surrounding ventilator withdrawal.
FAU - Feltman, D M
AU  - Feltman DM
AD  - Department of Pediatrics, NorthShore University HealthSystem, Evanston, IL, USA. 
      dfeltman@northshore.org
FAU - Du, H
AU  - Du H
FAU - Leuthner, S R
AU  - Leuthner SR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111215
PL  - United States
TA  - J Perinatol
JT  - Journal of perinatology : official journal of the California Perinatal
      Association
JID - 8501884
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Humans
MH  - Intensive Care Units, Neonatal
MH  - Life Support Care/ethics/statistics & numerical data
MH  - Multivariate Analysis
MH  - *Neonatology/ethics
MH  - Nutritional Support
MH  - Practice Patterns, Physicians'
MH  - Referral and Consultation
MH  - *Terminal Care/ethics
MH  - Withholding Treatment/ethics/statistics & numerical data
EDAT- 2011/12/17 06:00
MHDA- 2013/05/04 06:00
CRDT- 2011/12/17 06:00
PHST- 2011/12/17 06:00 [entrez]
PHST- 2011/12/17 06:00 [pubmed]
PHST- 2013/05/04 06:00 [medline]
AID - jp2011186 [pii]
AID - 10.1038/jp.2011.186 [doi]
PST - ppublish
SO  - J Perinatol. 2012 Nov;32(11):886-92. doi: 10.1038/jp.2011.186. Epub 2011 Dec 15.


PMID- 22172740
OWN - NLM
STAT- MEDLINE
DCOM- 20131231
LR  - 20130121
IS  - 1532-3099 (Electronic)
IS  - 0266-6138 (Linking)
VI  - 29
IP  - 1
DP  - 2013 Jan
TI  - Childbirth at home: a qualitative study exploring perceptions of risk and risk
      management among Baloch women in Iran.
PG  - 44-52
LID - 10.1016/j.midw.2011.11.001 [doi]
LID - S0266-6138(11)00180-X [pii]
AB  - OBJECTIVE: to explain how women who choose to give birth at home perceive and
      manage the risks related to childbirth. DESIGN: a qualitative, methodological
      approach drawing upon the principles of grounded theory. Data were gathered by
      in-depth interviews with women who had given birth at home. SETTING: the study
      was conducted in Zahedan, the capital of Sistan and Balochestan province in
      southeast Iran. PARTICIPANTS: 21 Baloch women aged 13-39 years who had a planned 
      home birth were interviewed. Nine had been attended by university-educated
      midwives, eight by trained midwives, and four by traditional birth attendants.
      FINDINGS: concerning perceived risks, women perceived giving birth in hospital to
      be risky because of medical interventions, routines and ethical considerations.
      The perceived risks for home birth were acute medical conditions. Women made
      their decision to give birth at home based on existing verbal, visual, and
      intuitive information. The following two categories related to risk management
      were identified: (1) psychological preparation and (2) medical and logistican
      preparation. All of the women relied on their own intuition, their midwife and
      the sociopsychological support of their families to transfer them to hospital in 
      the case of complications. KEY CONCLUSIONS AND IMPLICATIONS FOR PRACTICE: the
      women who chose to give birth at home accepted that there was a risk of
      complications, but perceived these to be due to fate. Technical risks were
      considered to be a consequence of the decision to give birth in hospital, and
      were perceived to be avoidable. In addition, the women considered ethical issues 
      as risks that are sometimes more important than medical complications. Women's
      perceptions of risk, and the ways in which they prepare to manage risk, are
      central issues to help providers and policy makers adjust services to women's
      expectations in order to respond to the individuality of each woman.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Abed Saeedi, Zhila
AU  - Abed Saeedi Z
AD  - Faculty of Nursing and Midwifery, Shaheed Beheshti University of Medical
      Sciences, Tehran, Iran.
FAU - Ghazi Tabatabaie, Mahmoud
AU  - Ghazi Tabatabaie M
FAU - Moudi, Zahra
AU  - Moudi Z
FAU - Vedadhir, Abou Ali
AU  - Vedadhir AA
FAU - Navidian, Ali
AU  - Navidian A
LA  - eng
PT  - Journal Article
DEP - 20111214
PL  - Scotland
TA  - Midwifery
JT  - Midwifery
JID - 8510930
MH  - Adolescent
MH  - Adult
MH  - Choice Behavior
MH  - Decision Making
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - *Home Childbirth/adverse effects/psychology
MH  - Humans
MH  - Iran/ethnology
MH  - Midwifery/*methods
MH  - Nurse-Patient Relations
MH  - *Obstetric Labor Complications/etiology/prevention & control/psychology
MH  - Patient Care Planning
MH  - Pregnancy
MH  - Pregnant Women/ethnology/psychology
MH  - Prenatal Education/methods
MH  - Qualitative Research
MH  - Risk Assessment/*methods
MH  - Social Support
EDAT- 2011/12/17 06:00
MHDA- 2014/01/01 06:00
CRDT- 2011/12/17 06:00
PHST- 2011/05/03 00:00 [received]
PHST- 2011/09/25 00:00 [revised]
PHST- 2011/11/06 00:00 [accepted]
PHST- 2011/12/17 06:00 [entrez]
PHST- 2011/12/17 06:00 [pubmed]
PHST- 2014/01/01 06:00 [medline]
AID - S0266-6138(11)00180-X [pii]
AID - 10.1016/j.midw.2011.11.001 [doi]
PST - ppublish
SO  - Midwifery. 2013 Jan;29(1):44-52. doi: 10.1016/j.midw.2011.11.001. Epub 2011 Dec
      14.


PMID- 22172453
OWN - NLM
STAT- MEDLINE
DCOM- 20121119
LR  - 20120703
IS  - 1557-9816 (Electronic)
IS  - 0955-470X (Linking)
VI  - 26
IP  - 3
DP  - 2012 Jul
TI  - Strategies for replacing myocytes with induced pluripotent stem in clinical
      protocols.
PG  - 223-32
LID - 10.1016/j.trre.2011.09.003 [doi]
AB  - Induced pluripotent stem (iPS) cells can be established via forced epigenetic
      reprogramming of various somatic cells and selection based on given criteria.
      Human iPS cells are preferred for clinical applications because they present
      fewer ethical concerns than embryonic stem cells. However, technical issues of
      stability and safety must be fully validated before clinical use. Moreover, heart
      regenerative therapies would require approximately 10(9) cardiomyocytes per
      person, necessitating the following technical considerations: (1) genetically and
      epigenetically stable scaling up of the iPS cells, (2) efficient and reproducible
      differentiation, and (3) highly reliable cell purification. Furthermore, (4)
      strategies for efficient iPS transplantation, rapid maturation, and functional
      integration of grafted cardiomyocytes into the host myocardium are critical unmet
      technologies. Herein, we discuss current progress and unmet problems for the
      realization of heart regenerative therapy.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Hattori, Fumiyuki
AU  - Hattori F
AD  - Department of Cardiology, Keio University School of Medicine, Tokyo, 160-8582,
      Japan. hattori.fumiyuki.ef@asubio.co.jp
FAU - Fukuda, Keiichi
AU  - Fukuda K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20111214
PL  - United States
TA  - Transplant Rev (Orlando)
JT  - Transplantation reviews (Orlando, Fla.)
JID - 8804364
SB  - IM
MH  - Animals
MH  - Cell Differentiation
MH  - Cells, Cultured
MH  - Graft Survival
MH  - Heart
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*cytology
MH  - Injections
MH  - Myocardial Infarction/*therapy
MH  - Myocytes, Cardiac/cytology/physiology/*transplantation
MH  - Regeneration
EDAT- 2011/12/17 06:00
MHDA- 2012/12/10 06:00
CRDT- 2011/12/17 06:00
PHST- 2010/09/03 00:00 [received]
PHST- 2011/03/21 00:00 [revised]
PHST- 2011/09/02 00:00 [accepted]
PHST- 2011/12/17 06:00 [entrez]
PHST- 2011/12/17 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - S0955-470X(11)00085-1 [pii]
AID - 10.1016/j.trre.2011.09.003 [doi]
PST - ppublish
SO  - Transplant Rev (Orlando). 2012 Jul;26(3):223-32. doi: 10.1016/j.trre.2011.09.003.
      Epub 2011 Dec 14.


PMID- 22171856
OWN - NLM
STAT- MEDLINE
DCOM- 20120209
LR  - 20190902
IS  - 1326-5377 (Electronic)
IS  - 0025-729X (Linking)
VI  - 195
IP  - 11-12
DP  - 2011 Dec 19
TI  - Is it ethical for medical practitioners to prescribe alternative and
      complementary treatments that may lack an evidence base?
PG  - 660-1
FAU - Tam, Chun Wah M
AU  - Tam CW
LA  - eng
PT  - Letter
PT  - Comment
PL  - Australia
TA  - Med J Aust
JT  - The Medical journal of Australia
JID - 0400714
SB  - IM
CON - Med J Aust. 2011 Jul 18;195(2):78. PMID: 21770875
CON - Med J Aust. 2011 Jul 18;195(2):79. PMID: 21770876
MH  - Complementary Therapies/*ethics
MH  - Evidence-Based Medicine/*ethics
MH  - Humans
EDAT- 2011/12/17 06:00
MHDA- 2012/02/10 06:00
CRDT- 2011/12/17 06:00
PHST- 2011/10/18 00:00 [received]
PHST- 2011/10/30 00:00 [accepted]
PHST- 2011/12/17 06:00 [entrez]
PHST- 2011/12/17 06:00 [pubmed]
PHST- 2012/02/10 06:00 [medline]
AID - letters_121211_fm-2 [pii]
AID - 10.5694/mja11.11333 [doi]
PST - ppublish
SO  - Med J Aust. 2011 Dec 19;195(11-12):660-1. doi: 10.5694/mja11.11333.


PMID- 22171458
OWN - NLM
STAT- MEDLINE
DCOM- 20120119
LR  - 20111216
IS  - 0882-1577 (Print)
IS  - 0882-1577 (Linking)
VI  - 92
IP  - 6
DP  - 2011 Nov-Dec
TI  - Nurturing ethicists for the future of Catholic health care.
PG  - 83-5
FAU - Father Thomas Nairn
AU  - Father Thomas Nairn
AD  - Catholic Health Association, St. Louis, USA. tnairn@chausa.org
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Health Prog
JT  - Health progress (Saint Louis, Mo.)
JID - 8500263
MH  - *Catholicism
MH  - Data Collection
MH  - Delivery of Health Care/*ethics
MH  - *Ethicists/supply & distribution
MH  - Humans
MH  - United States
EDAT- 2011/12/17 06:00
MHDA- 2012/01/20 06:00
CRDT- 2011/12/17 06:00
PHST- 2011/12/17 06:00 [entrez]
PHST- 2011/12/17 06:00 [pubmed]
PHST- 2012/01/20 06:00 [medline]
PST - ppublish
SO  - Health Prog. 2011 Nov-Dec;92(6):83-5.


PMID- 22171453
OWN - NLM
STAT- MEDLINE
DCOM- 20120119
LR  - 20111216
IS  - 0882-1577 (Print)
IS  - 0882-1577 (Linking)
VI  - 92
IP  - 6
DP  - 2011 Nov-Dec
TI  - The ethics of cost control. Wasteful treatments undermine health care for all.
PG  - 68-74
FAU - Weber, Leonard J
AU  - Weber LJ
AD  - University of Detroit Mercy, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Health Prog
JT  - Health progress (Saint Louis, Mo.)
JID - 8500263
MH  - Cost Control/*ethics
MH  - Delivery of Health Care/*economics
MH  - Humans
MH  - United States
MH  - Unnecessary Procedures/*economics
EDAT- 2011/12/17 06:00
MHDA- 2012/01/20 06:00
CRDT- 2011/12/17 06:00
PHST- 2011/12/17 06:00 [entrez]
PHST- 2011/12/17 06:00 [pubmed]
PHST- 2012/01/20 06:00 [medline]
PST - ppublish
SO  - Health Prog. 2011 Nov-Dec;92(6):68-74.


PMID- 23502911
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 2157-7617 (Print)
IS  - 2157-7617 (Linking)
VI  - S1
DP  - 2011 Dec 17
TI  - Geoengineering: An Idea Whose Time Has Come?
LID - 001 [pii]
AB  - Some engineers and scientists recently have suggested that it would be prudent to
      consider engaging in geoengineering to mitigate global warming. Geoengineering
      differs from other methods for mitigating global warming because it involves a
      deliberate effort to affect the climate at a global scale. Although
      geoengineering is not a new idea, it has taken on added significance as a result 
      of difficulties with implementing other proposals to mitigate climate change.
      While proponents of geoengineering admit that it can have significant risks for
      the environment and public health, many maintain that it is worth pursuing, given
      the failure of other means of mitigating global warming. Some environmental
      groups have voiced strong opposition to all forms of geoengineering. In this
      article, we examine arguments for and against geoengineering and discuss some
      policy options. We argue that specific geoengineering proposals should not be
      implemented until there is good evidence concerning their safety, efficacy, and
      feasibility, as well as a plan for oversight. International cooperation and
      public input should also be sought. Other methods for mitigating global warming
      should be aggressively pursued while geoengineering is under consideration. The
      promise of an engineering solution to global warming should not be used as an
      excuse to abandon or cut back current, climate mitigation efforts.
FAU - Resnik, David B
AU  - Resnik DB
AD  - National Institute of Environmental Health Sciences, National Institutes of
      Health, Box 12233, Mail Drop CU-03, Research Triangle Park, NC, 27709, USA.
FAU - Vallero, Daniel A
AU  - Vallero DA
LA  - eng
GR  - ZIA ES102646-04/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - J Earth Sci Clim Change
JT  - Journal of earth science & climatic change
JID - 101598002
PMC - PMC3596048
MID - NIHMS426030
OTO - NOTNLM
OT  - Climate mitigation
OT  - Ethics
OT  - Geoengineering
OT  - Global warming
OT  - Policy
OT  - Risk
EDAT- 2011/12/17 00:00
MHDA- 2011/12/17 00:01
CRDT- 2013/03/19 06:00
PHST- 2013/03/19 06:00 [entrez]
PHST- 2011/12/17 00:00 [pubmed]
PHST- 2011/12/17 00:01 [medline]
PST - ppublish
SO  - J Earth Sci Clim Change. 2011 Dec 17;S1.


PMID- 22170940
OWN - NLM
STAT- MEDLINE
DCOM- 20121023
LR  - 20211021
IS  - 1470-2738 (Electronic)
IS  - 0143-005X (Linking)
VI  - 66
IP  - 7
DP  - 2012 Jul
TI  - Global health governance as shared health governance.
PG  - 653-61
LID - 10.1136/jech.2009.101097 [doi]
AB  - BACKGROUND: With the exception of key 'proven successes' in global health, the
      current regime of global health governance can be understood as transnational and
      national actors pursuing their own interests under a rational actor model of
      international cooperation, which fails to provide sufficient justification for an
      obligation to assist in meeting the health needs of others. An ethical commitment
      to providing all with the ability to be healthy is required. METHODS: This
      article develops select components of an alternative model of shared health
      governance (SHG), which aims to provide a 'road map,' 'focal points' and 'the
      glue' among various global health actors to better effectuate cooperation on
      universal ethical principles for an alternative global health equilibrium. Key
      features of SHG include public moral norms as shared authoritative standards;
      ethical commitments, shared goals and role allocation; shared sovereignty and
      constitutional commitments; legitimacy and accountability; country-level
      attention to international health relations. RESULTS: A framework of social
      agreement based on 'overlapping consensus' is contrasted against one based on
      self-interested political bargaining. A global health constitution delineating
      duties and obligations of global health actors and a global institute of health
      and medicine for holding actors responsible are proposed. Indicators for
      empirical assessment of select SHG principles are described. CONCLUSION: Global
      health actors, including states, must work together to correct and avert global
      health injustices through a framework of SHG based on shared ethical commitments.
FAU - Ruger, Jennifer Prah
AU  - Ruger JP
AD  - Yale University School of Public Health, 60 College Street, PO Box 208034, New
      Haven, CT 06520, USA. jennifer.ruger@yale.edu
LA  - eng
GR  - K01 DA016358/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111214
PL  - England
TA  - J Epidemiol Community Health
JT  - Journal of epidemiology and community health
JID - 7909766
SB  - IM
MH  - *Global Health
MH  - Humans
MH  - *International Cooperation
MH  - *Models, Organizational
EDAT- 2011/12/16 06:00
MHDA- 2012/10/24 06:00
CRDT- 2011/12/16 06:00
PHST- 2011/12/16 06:00 [entrez]
PHST- 2011/12/16 06:00 [pubmed]
PHST- 2012/10/24 06:00 [medline]
AID - jech.2009.101097 [pii]
AID - 10.1136/jech.2009.101097 [doi]
PST - ppublish
SO  - J Epidemiol Community Health. 2012 Jul;66(7):653-61. doi:
      10.1136/jech.2009.101097. Epub 2011 Dec 14.


PMID- 22170631
OWN - NLM
STAT- MEDLINE
DCOM- 20120917
LR  - 20151119
IS  - 1099-0496 (Electronic)
IS  - 1099-0496 (Linking)
VI  - 47
IP  - 6
DP  - 2012 Jun
TI  - International survey of physician recommendation for tracheostomy for Spinal
      Muscular Atrophy Type I.
PG  - 606-11
LID - 10.1002/ppul.21617 [doi]
AB  - The ethics of invasive mechanical ventilation for children with the
      neurodegenerative disease Spinal Muscular Atrophy Type I (SMA I) is highly
      debated, and wide variability in clinical outcomes exists internationally. We
      conducted this international survey to identify physician characteristics
      associated with recommendation for tracheostomy and ventilation for SMA I. A
      cross-sectional online survey was distributed to 1,772 pediatric pulmonologists
      and pediatric intensivists from online membership directories of American
      Thoracic Society, American College of Chest Physicians, and European Respiratory 
      Society. Questions explored physician demographics, attitudes and experience with
      SMA and end-of-life care, knowledge of consensus guidelines, and recommendations 
      for respiratory care of SMA I. A logistic regression model assessed the
      independent effects of physician variables on the recommendation for invasive
      ventilation for SMA I. A total of 367 (21%) physicians completed the survey; 82% 
      were pediatric pulmonologists; and 16% pediatric intensivists. Seventy percent of
      respondents were from the U.S. Fifty percent of physicians were aware of SMA
      consensus guidelines. Physicians from Commonwealth countries (U.K., Canada,
      Australia, etc.) were less likely to recommend tracheostomy/ventilation than U.S.
      physicians (7% vs. 25%, P = 0.005). Logistic regression modeling identified years
      of experience, pediatric pulmonology specialty, agreement with a pro-life
      statement, and recommendation for non-invasive ventilation as predictive of
      recommendation for long-term invasive ventilation for SMA I. In the largest
      international survey on this topic, we identified regional differences in
      physician recommendation for invasive ventilation for children with SMA I. Our
      data demonstrate a need for increased awareness of consensus guidelines and
      further dialog about the physician role in variability of care for children with 
      SMA I.
CI  - Copyright (c) 2011 Wiley Periodicals, Inc.
FAU - Benson, Renee C
AU  - Benson RC
AD  - Bay Area Pediatric Pulmonary Medical Corporation, Oakland, California, USA.
      rbenson@mail.cho.org
FAU - Hardy, Karen A
AU  - Hardy KA
FAU - Gildengorin, Ginny
AU  - Gildengorin G
FAU - Hsia, Danny
AU  - Hsia D
LA  - eng
PT  - Journal Article
DEP - 20111213
PL  - United States
TA  - Pediatr Pulmonol
JT  - Pediatric pulmonology
JID - 8510590
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - *Pediatrics
MH  - *Physicians
MH  - Practice Patterns, Physicians'/*ethics/statistics & numerical data
MH  - Respiration, Artificial/*ethics
MH  - Spinal Muscular Atrophies of Childhood/*surgery
MH  - Tracheostomy/*ethics
EDAT- 2011/12/16 06:00
MHDA- 2012/09/18 06:00
CRDT- 2011/12/16 06:00
PHST- 2011/07/04 00:00 [received]
PHST- 2011/09/26 00:00 [accepted]
PHST- 2011/12/16 06:00 [entrez]
PHST- 2011/12/16 06:00 [pubmed]
PHST- 2012/09/18 06:00 [medline]
AID - 10.1002/ppul.21617 [doi]
PST - ppublish
SO  - Pediatr Pulmonol. 2012 Jun;47(6):606-11. doi: 10.1002/ppul.21617. Epub 2011 Dec
      13.


PMID- 22170503
OWN - NLM
STAT- MEDLINE
DCOM- 20131213
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 2
DP  - 2013 Jun
TI  - Using the Chernobyl incident to teach engineering ethics.
PG  - 625-40
LID - 10.1007/s11948-011-9337-4 [doi]
AB  - This paper discusses using the Chernobyl Incident as a case study in engineering 
      ethics instruction. Groups of students are asked to take on the role of a faction
      involved in the Chernobyl disaster and to defend their decisions in a mock
      debate. The results of student surveys and the Engineering and Science Issues
      Test indicate that the approach is very popular with students and has a positive 
      impact on moral reasoning. The approach incorporates technical, communication and
      teamwork skills and has many of the features suggested by recent literature.
FAU - Wilson, William R
AU  - Wilson WR
AD  - Muskingum University, New Concord, OH, USA. rwilson@muskingum.edu
LA  - eng
PT  - Journal Article
DEP - 20111215
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Chernobyl Nuclear Accident
MH  - Data Collection
MH  - Decision Making/*ethics
MH  - *Engineering/education/ethics
MH  - Humans
MH  - *Morals
MH  - Problem Solving/*ethics
MH  - Problem-Based Learning/*methods
MH  - Students
EDAT- 2011/12/16 06:00
MHDA- 2013/12/18 06:00
CRDT- 2011/12/16 06:00
PHST- 2011/07/16 00:00 [received]
PHST- 2011/11/24 00:00 [accepted]
PHST- 2011/12/16 06:00 [entrez]
PHST- 2011/12/16 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
AID - 10.1007/s11948-011-9337-4 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Jun;19(2):625-40. doi: 10.1007/s11948-011-9337-4. Epub 2011 
      Dec 15.


PMID- 22169524
OWN - NLM
STAT- MEDLINE
DCOM- 20140106
LR  - 20151119
IS  - 1532-3099 (Electronic)
IS  - 0266-6138 (Linking)
VI  - 28
IP  - 6
DP  - 2012 Dec
TI  - Attitudes of Swedish midwives towards management of extremely preterm labour and 
      birth.
PG  - e857-64
LID - 10.1016/j.midw.2011.10.009 [doi]
LID - S0266-6138(11)00172-0 [pii]
AB  - OBJECTIVE: the aim of the study was to ascertain the attitudes of Swedish
      midwives towards management of very preterm labour and birth and to compare the
      attitudes of midwives at university hospitals with those at general hospitals.
      DESIGN: this cross-sectional descriptive and comparative study used an anonymous 
      self-administrated questionnaire for data collection. Descriptive and analytic
      statistics were carried out for analysis. PARTICIPANTS: the answers from midwives
      (n=259) were collected in a prospective SWEMID study. SETTING: the midwives had
      experience of working on delivery wards in maternity units with neonatal
      intensive care units (NICU) in Sweden. FINDINGS: in the management of very
      preterm labour and birth, midwives agreed to initiate interventions concerning
      steroid prophylaxis at 23 gestational weeks (GW), caesarean section for preterm
      labour only at 25 GW, when to give information to the neonatologist before birth 
      at 23 GW, and when to suggest transfer to NICU at 23 GW. Midwives at university
      hospitals were prone to start interventions at an earlier gestational age than
      the midwives at general hospitals. Midwives at university hospitals seemed to be 
      more willing to disclose information to the parents. KEY CONCLUSIONS: midwives
      with experience of handling very preterm births at 21-28 GW develop a positive
      attitude to interventions at an earlier gestational age as compared to midwives
      without such experience. IMPLICATIONS FOR PRACTICE: based on these results we
      suggest more communication and transfer of information about the advances in
      perinatal care and exchange of knowledge between the staff at general and
      university hospitals. Establishment of platforms for inter-professional
      discussions about ethically difficult situations in perinatal care, might benefit
      the management of very preterm labour and birth.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Danerek, Margaretha
AU  - Danerek M
AD  - Department of Health Sciences, Faculty of Medicine, University Lund, Box 157, 221
      00 Lund, Sweden. margaretha.danerek@med.lu.se
FAU - Marsal, Karel
AU  - Marsal K
FAU - Cuttini, Marina
AU  - Cuttini M
FAU - Lingman, Goran
AU  - Lingman G
FAU - Nilstun, Tore
AU  - Nilstun T
FAU - Dykes, Anna-Karin
AU  - Dykes AK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111212
PL  - Scotland
TA  - Midwifery
JT  - Midwifery
JID - 8510930
MH  - Adult
MH  - Female
MH  - Humans
MH  - *Infant, Extremely Premature
MH  - Infant, Newborn
MH  - Intensive Care, Neonatal/methods
MH  - Interprofessional Relations
MH  - Midwifery/*methods
MH  - *Nurse's Role
MH  - Nurse-Patient Relations
MH  - Nursing Methodology Research
MH  - Postnatal Care/*methods
MH  - Pregnancy
MH  - Pregnancy, High-Risk
MH  - Premature Birth/*nursing
MH  - Surveys and Questionnaires
MH  - Sweden
MH  - Young Adult
EDAT- 2011/12/16 06:00
MHDA- 2014/01/07 06:00
CRDT- 2011/12/16 06:00
PHST- 2010/10/21 00:00 [received]
PHST- 2011/10/19 00:00 [revised]
PHST- 2011/10/24 00:00 [accepted]
PHST- 2011/12/16 06:00 [entrez]
PHST- 2011/12/16 06:00 [pubmed]
PHST- 2014/01/07 06:00 [medline]
AID - S0266-6138(11)00172-0 [pii]
AID - 10.1016/j.midw.2011.10.009 [doi]
PST - ppublish
SO  - Midwifery. 2012 Dec;28(6):e857-64. doi: 10.1016/j.midw.2011.10.009. Epub 2011 Dec
      12.


PMID- 22168822
OWN - NLM
STAT- MEDLINE
DCOM- 20120320
LR  - 20220330
IS  - 1471-0528 (Electronic)
IS  - 1470-0328 (Linking)
VI  - 119
IP  - 3
DP  - 2012 Feb
TI  - Historical trends in the timing of informed consent for research into intrapartum
      complications.
PG  - 361-5
LID - 10.1111/j.1471-0528.2011.03204.x [doi]
AB  - Obtaining informed consent for clinical trials involving the management of
      intrapartum complications is complex. This article describes the strategies used 
      to obtain consent over the last 60 years using data from the Cochrane Library. Of
      138 intrapartum randomised studies, 37% had no record of the consent procedures. 
      Of the remainder, 74% sought consent only when the complication developed, 11%
      sought consent from all women in early labour, and 13% gave all women antenatal
      information and then sought written consent when the complication arose. Despite 
      the existence of ethics guidelines for intrapartum consent, many studies fail to 
      follow their advice.
CI  - (c) 2011 The Authors BJOG An International Journal of Obstetrics and Gynaecology 
      (c) 2011 RCOG.
FAU - Patel, D
AU  - Patel D
AD  - University of Liverpool, Liverpool, UK.
FAU - Nasir, S
AU  - Nasir S
FAU - Elati, A
AU  - Elati A
FAU - Vernon, G
AU  - Vernon G
FAU - Weeks, A D
AU  - Weeks AD
LA  - eng
PT  - Historical Article
PT  - Journal Article
DEP - 20111213
PL  - England
TA  - BJOG
JT  - BJOG : an international journal of obstetrics and gynaecology
JID - 100935741
SB  - IM
MH  - Bibliometrics
MH  - Female
MH  - Guideline Adherence
MH  - Guidelines as Topic
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Informed Consent/ethics/*history
MH  - Obstetric Labor Complications/*history
MH  - Pregnancy
MH  - Randomized Controlled Trials as Topic
MH  - *Research Design
EDAT- 2011/12/16 06:00
MHDA- 2012/03/21 06:00
CRDT- 2011/12/16 06:00
PHST- 2011/12/16 06:00 [entrez]
PHST- 2011/12/16 06:00 [pubmed]
PHST- 2012/03/21 06:00 [medline]
AID - 10.1111/j.1471-0528.2011.03204.x [doi]
PST - ppublish
SO  - BJOG. 2012 Feb;119(3):361-5. doi: 10.1111/j.1471-0528.2011.03204.x. Epub 2011 Dec
      13.


PMID- 22168578
OWN - NLM
STAT- MEDLINE
DCOM- 20120503
LR  - 20211021
IS  - 1521-0499 (Electronic)
IS  - 0190-2148 (Linking)
VI  - 38
IP  - 1
DP  - 2012 Feb
TI  - Resilience of the human fetal lung following stillbirth: potential relevance for 
      pulmonary regenerative medicine.
PG  - 43-54
LID - 10.3109/01902148.2011.641139 [doi]
AB  - Recent advances in pulmonary regenerative medicine have increased the demand for 
      alveolar epithelial progenitor cells. Fetal lung tissues from spontaneous
      pregnancy losses may represent a neglected, yet ethically and societally
      acceptable source of alveolar epithelial cells. The aim of this study was to
      determine the regenerative capacity of fetal lungs obtained from second trimester
      stillbirths. Lung tissues were harvested from 11 stillborn fetuses (13 to 22
      weeks' gestation) at postdelivery intervals ranging from 10 to 41 hours and
      grafted to the renal subcapsular space of immune-suppressed rats to provide
      optimal growth conditions. Histology, epithelial and alveolar type II cell
      proliferation, and surfactant protein-C mRNA expression were studied in
      preimplantation lung tissues and in xenografts at posttransplantation week 2. All
      xenografts displayed advanced architectural maturation compared with their
      respective preimplantation tissues, regardless of gestational age and
      postdelivery interval. The proliferative activity of the grafts was significantly
      higher than that of the preimplantation tissues (mean Ki-67 labeling index
      26.7%+/-7.7% versus 14.7%+/-10.5%; P<.01). The proliferative activity of grafts
      obtained after a long (>36 hours) postdelivery interval was significantly higher 
      than that of the corresponding preimplantation tissue, and equivalent to that of 
      grafts obtained after a short postdelivery interval (<14 hours). The regenerative
      capacity of fetal lung tissue was greater at younger (13 to 17 weeks) than at
      older (19 to 22 weeks) gestational ages. The presence of
      inflammation/chorioamnionitis did not appear to affect graft regeneration. All
      grafts studied displayed robust surfactant protein-C mRNA expression. In
      conclusion, fetal lung tissues from second trimester stillbirths can regain their
      inherent high regenerative potential following short-term culture, even if
      harvested more than 36 hours after delivery.
FAU - De Paepe, Monique E
AU  - De Paepe ME
AD  - Department of Pathology, Women and Infants Hospital, and Department of Pathology 
      and Laboratory Medicine, Alpert Medical School of Brown University, Providence,
      Rhode Island 02905, USA. mdepaepe@wihri.org
FAU - Chu, Sharon
AU  - Chu S
FAU - Heger, Nicholas
AU  - Heger N
FAU - Hall, Susan
AU  - Hall S
FAU - Mao, Quanfu
AU  - Mao Q
LA  - eng
GR  - P20 ES018169/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20111214
PL  - England
TA  - Exp Lung Res
JT  - Experimental lung research
JID - 8004944
RN  - 0 (Pulmonary Surfactant-Associated Protein C)
RN  - 0 (Pulmonary Surfactants)
RN  - 0 (RNA, Messenger)
RN  - 0 (SFTPC protein, human)
SB  - IM
MH  - Animals
MH  - Chorioamnionitis/metabolism/pathology
MH  - Epithelial Cells/cytology/metabolism
MH  - Female
MH  - Fetus
MH  - Humans
MH  - Lung/cytology/*embryology/*physiology
MH  - Lung Transplantation
MH  - Male
MH  - Pregnancy
MH  - Pulmonary Alveoli/cytology/metabolism/*physiology
MH  - Pulmonary Medicine/methods
MH  - Pulmonary Surfactant-Associated Protein C/biosynthesis/genetics
MH  - Pulmonary Surfactants/metabolism
MH  - RNA, Messenger/biosynthesis/genetics
MH  - Rats
MH  - Regeneration/genetics/*physiology
MH  - Regenerative Medicine/*methods
MH  - Respiratory Mucosa/cytology/metabolism
MH  - Stillbirth
MH  - Transplantation, Heterologous
PMC - PMC3677542
MID - NIHMS469771
EDAT- 2011/12/16 06:00
MHDA- 2012/05/04 06:00
CRDT- 2011/12/16 06:00
PHST- 2011/12/16 06:00 [entrez]
PHST- 2011/12/16 06:00 [pubmed]
PHST- 2012/05/04 06:00 [medline]
AID - 10.3109/01902148.2011.641139 [doi]
PST - ppublish
SO  - Exp Lung Res. 2012 Feb;38(1):43-54. doi: 10.3109/01902148.2011.641139. Epub 2011 
      Dec 14.


PMID- 22168354
OWN - NLM
STAT- MEDLINE
DCOM- 20120418
LR  - 20120227
IS  - 1749-6632 (Electronic)
IS  - 0077-8923 (Linking)
VI  - 1249
DP  - 2012 Feb
TI  - Artificial persons against nature: environmental governmentality, economic
      corporations, and ecological ethics.
PG  - 104-17
LID - 10.1111/j.1749-6632.2011.06294.x [doi]
AB  - Despite the 194 nation-state signatories to the global Convention on Biological
      Diversity, the conservation effort is failing to halt an ongoing spiral of
      decline in most habitats and ecological communities on land and ocean.
      Environmental ethicists argue that the failure to halt the unsustainable
      predation on the ecosystems that sustain industrial civilization is indicative of
      a moral as well as a scientific crisis. Principal ethical interventions in
      ecology include the ascription of value to species and ecosystems, wilderness
      ethics, and ecological virtue. Ecological virtue ethics identifies agency,
      character, institutions, and practices as crucial to moral formation and
      outcomes. However, the dominant role of the economic corporation in ecological
      destruction subverts a virtues approach. Corporations as fictive persons will not
      learn ecological virtue absent of legal and regulatory reform and the ecological 
      education of business leaders and owners.
CI  - (c) 2012 New York Academy of Sciences.
FAU - Northcott, Michael S
AU  - Northcott MS
AD  - School of Divinity, University of Edinburgh, United Kingdom. m.northcott@ed.ac.uk
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111214
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
SB  - IM
MH  - Animals
MH  - Biodiversity
MH  - Conservation of Natural Resources/*economics/legislation & jurisprudence
MH  - Ecology/*economics/*ethics/legislation & jurisprudence
MH  - Ecosystem
MH  - Endangered Species
EDAT- 2011/12/16 06:00
MHDA- 2012/04/19 06:00
CRDT- 2011/12/16 06:00
PHST- 2011/12/16 06:00 [entrez]
PHST- 2011/12/16 06:00 [pubmed]
PHST- 2012/04/19 06:00 [medline]
AID - 10.1111/j.1749-6632.2011.06294.x [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2012 Feb;1249:104-17. doi: 10.1111/j.1749-6632.2011.06294.x.
      Epub 2011 Dec 14.


PMID- 22168060
OWN - NLM
STAT- MEDLINE
DCOM- 20120209
LR  - 20181201
IS  - 0869-866X (Print)
IS  - 0869-866X (Linking)
IP  - 4
DP  - 2011 Jul-Aug
TI  - [The social psychological support of the system of quality management in medical 
      organization].
PG  - 26-30
AB  - The effective activities of any medical organization targeted to enhance the
      consumer's satisfaction require the implementation of the actual techniques and
      organizational technologies of quality management. The social psychological
      techniques based on the system approach and up-to-date innovations play the key
      role. The study intends a required involvement of medical personnel and direction
      of their efforts to the continual enhancement of their activities. The core
      purpose of the study was to develop the system of social psychological support of
      its basic element--the ethical standard of medical personnel. The involvement of 
      all personnel in the medical organization makes it possible to develop in
      employees the commitment to the postulates of ethical standard and to decrease
      the risks of opposition to innovations. The comprehensive approach of developing 
      of the subsystem of social psychological support within the structure of the
      quality management system to facilitate the practical implementation and
      improvement of all components is considered. This design ensures the amelioration
      of effectiveness of activities, sustainable development and competitiveness of
      modern medical organization.
FAU - Beliakin, S A
AU  - Beliakin SA
FAU - Kazakova, T V
AU  - Kazakova TV
FAU - Breskina, T N
AU  - Breskina TN
FAU - Azbarov, A A
AU  - Azbarov AA
FAU - Koval'chuk, M M
AU  - Koval'chuk MM
LA  - rus
PT  - Journal Article
PL  - Russia (Federation)
TA  - Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med
JT  - Problemy sotsial'noi gigieny, zdravookhraneniia i istorii meditsiny
JID - 101270373
SB  - IM
MH  - *Ethics, Business
MH  - *Health Facilities
MH  - Health Personnel/*ethics/*psychology
MH  - Humans
MH  - Russia
MH  - *Social Support
MH  - Workforce
EDAT- 2011/12/16 06:00
MHDA- 2012/02/10 06:00
CRDT- 2011/12/16 06:00
PHST- 2011/12/16 06:00 [entrez]
PHST- 2011/12/16 06:00 [pubmed]
PHST- 2012/02/10 06:00 [medline]
PST - ppublish
SO  - Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med. 2011 Jul-Aug;(4):26-30.


PMID- 22167990
OWN - NLM
STAT- MEDLINE
DCOM- 20120110
LR  - 20220309
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 22
IP  - 3
DP  - 2011 Fall
TI  - The findings of the Dartmouth Atlas Project: a challenge to clinical and ethical 
      excellence in end-of-life care.
PG  - 267-76
AB  - The Dartmouth Institute for Health Policy and Clinical Practice Atlas Project
      found "staggering variations" in the quality and quantity of end-of-life care
      provided to Medicare patients with severe chronic illness across the United
      States. Particularly concerning is the finding that more care is provided to
      patients who live in "high-supply" areas, irrespective of the effectiveness of
      care, and that more care often equaled inappropriate care that increased
      patients' suffering at the end of life. Patients in "lower supply" areas
      typically received better, more appropriate levels of care and reported higher
      levels of satisfaction with the care they received.
FAU - Mitchell, John J Jr
AU  - Mitchell JJ Jr
AD  - Department of Biomedical Ethics, School of Health and Medical Sciences, Seton
      Hall University, South Orange, New Jersey, USA. mitchejo@shu.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Beneficence
MH  - Chronic Disease/therapy
MH  - Clinical Competence
MH  - Empathy
MH  - Ethics, Medical
MH  - *Health Services Accessibility/ethics/standards/trends
MH  - Humans
MH  - Informed Consent
MH  - Medicare
MH  - Personal Autonomy
MH  - Physician-Patient Relations/*ethics
MH  - *Quality of Health Care/ethics/standards/trends
MH  - Severity of Illness Index
MH  - Terminal Care/*ethics/methods/*organization & administration/standards/trends
MH  - Truth Disclosure
MH  - United States
EDAT- 2011/12/16 06:00
MHDA- 2012/01/11 06:00
CRDT- 2011/12/16 06:00
PHST- 2011/12/16 06:00 [entrez]
PHST- 2011/12/16 06:00 [pubmed]
PHST- 2012/01/11 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2011 Fall;22(3):267-76.


PMID- 22167989
OWN - NLM
STAT- MEDLINE
DCOM- 20120110
LR  - 20151119
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 22
IP  - 3
DP  - 2011 Fall
TI  - Mind the gap: the lack of common language in healthcare ethics.
PG  - 261-6
AB  - Ethics consultation services provide support to staff, patients, and family
      members who find themselves in morally difficult situations in healthcare
      settings. Not unlike other clinical consultation services, ethics consultation
      activities should be well documented. Good documentation allows for evaluation of
      the consultation process and the ability to refer back to consults when needed,
      and provides data for future research in healthcare ethics (HCE). In our
      exploration of existing HCE documentation systems, we identified two main points 
      of interest. First, HCE information documentation systems are powerful tools for 
      providing information on ethics consultation services.These documentation systems
      can be used to produce detailed reports on various HCE activities both
      institutionally and cross-institutionally. Second, our findings indicate greater 
      agreement in the language and terminology of HCE needs to be established.
      Cultivation of such common language is needed in order to develop a standard
      healthcare ethicists can use to document and categorize consults. Standardization
      of language would allow data to be readily comparable and lead to more
      consistency in documentation of ethics consultations. Ultimately, standardization
      of documentation can also constitute a standard of practice for HCE in
      general.The development of such standards is essential for any developing
      profession, and will be required for HCE as it moves in towards
      professionalization in Canada.
FAU - Kekewich, Michael A
AU  - Kekewich MA
AD  - Department of Clinical and Organizational Ethics, Ottawa Hospital, Ontario,
      Canada. mkekewich@toh.on.ca
FAU - Curran, Dorothyann
AU  - Curran D
FAU - Cornick, Jennifer L
AU  - Cornick JL
FAU - Foreman, Thomas C
AU  - Foreman TC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
MH  - *Bioethics
MH  - Canada
MH  - *Communication
MH  - Cooperative Behavior
MH  - Ethics Consultation/*standards
MH  - Hospital Records/*standards
MH  - Humans
MH  - *Language
MH  - Medical Records/*standards
MH  - Ontario
MH  - Reference Standards
MH  - Surveys and Questionnaires
EDAT- 2011/12/16 06:00
MHDA- 2012/01/11 06:00
CRDT- 2011/12/16 06:00
PHST- 2011/12/16 06:00 [entrez]
PHST- 2011/12/16 06:00 [pubmed]
PHST- 2012/01/11 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2011 Fall;22(3):261-6.


PMID- 22167988
OWN - NLM
STAT- MEDLINE
DCOM- 20120110
LR  - 20181201
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 22
IP  - 3
DP  - 2011 Fall
TI  - Exemplary cases in clinical ethics: commentary on the case of Mr. A.
PG  - 256-60
AB  - A commentary on a case of a man who is left a "high quad" (ventilator dependant
      as well as quadriplegic) after an accident discusses the following: The right of 
      patients who sustain catastrophic injuries to choose to discontinue
      life-sustaining treatment, The role of capacity assessment in treatment decisions
      and in ethics consultations, The role of advance directives (ADs) for such
      patients if they lack capacity, Whether a do-not-resuscitate or
      do-not-attempt-resuscitation order should be seen as "a medical order" or an
      advance directive, Some hints about what might be intended when a patient refers 
      to the criterion of having a "meaningful life."
FAU - Spike, Jeffrey
AU  - Spike J
AD  - McGovern Center for Humanities and Ethics, University of Texas, Houston, USA.
      Jeffrey.P.Spike@uth.tmc.edu
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
CON - J Clin Ethics. 2011 Fall;22(3):250-5. PMID: 22167987
MH  - Advance Directive Adherence/*ethics
MH  - *Communication Barriers
MH  - *Decision Making
MH  - *Ethics Consultation
MH  - Humans
MH  - *Living Wills
MH  - Male
MH  - *Mental Competency
MH  - *Personal Autonomy
MH  - Withholding Treatment/*ethics
EDAT- 2011/12/16 06:00
MHDA- 2012/01/11 06:00
CRDT- 2011/12/16 06:00
PHST- 2011/12/16 06:00 [entrez]
PHST- 2011/12/16 06:00 [pubmed]
PHST- 2012/01/11 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2011 Fall;22(3):256-60.


PMID- 22167987
OWN - NLM
STAT- MEDLINE
DCOM- 20120110
LR  - 20111215
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 22
IP  - 3
DP  - 2011 Fall
TI  - Clinical ethics case report: questionable capacity and the guidance of living
      wills.
PG  - 250-5
AB  - After falling from a roof, an older man lost neurological function below his
      face. In two days, the patient regained consciousness, but it was unclear whether
      he could communicate his preferences, whether due to injuries or difficulties
      with language. His family believed he could communicate with them, and that he
      was capable of making treatment decisions. The staff did not think to contact the
      hospital's largely inactive ethics consultation service for assistance, and
      instead looked to the patient's living will for guidance, even though the patient
      was not terminally ill, and his lack of capacity had not been determined.
FAU - VanderWalde, Ari
AU  - VanderWalde A
AD  - Department of Hematology and Medical Oncology, City of Hope National Medical
      Center, Duarte, California, USA. arivanderw@gmail.com
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
CIN - J Clin Ethics. 2011 Fall;22(3):256-60. PMID: 22167988
MH  - Accidental Falls
MH  - Advance Directive Adherence/*ethics
MH  - Aged
MH  - Cervical Vertebrae/injuries
MH  - *Communication Barriers
MH  - *Decision Making
MH  - *Ethics Consultation/ethics/standards
MH  - Ethics, Medical
MH  - Ethics, Nursing
MH  - Humans
MH  - Italy
MH  - Language
MH  - *Living Wills
MH  - Male
MH  - *Mental Competency
MH  - *Personal Autonomy
MH  - Resuscitation Orders/ethics
MH  - Spinal Fractures/complications/etiology
MH  - Translations
MH  - Withholding Treatment/*ethics
EDAT- 2011/12/16 06:00
MHDA- 2012/01/11 06:00
CRDT- 2011/12/16 06:00
PHST- 2011/12/16 06:00 [entrez]
PHST- 2011/12/16 06:00 [pubmed]
PHST- 2012/01/11 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2011 Fall;22(3):250-5.


PMID- 22167984
OWN - NLM
STAT- MEDLINE
DCOM- 20120110
LR  - 20191210
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 22
IP  - 3
DP  - 2011 Fall
TI  - Training currently practicing members of the ethics consultation service: one
      institution's experience.
PG  - 217-22
AB  - Most hospitals and nursing homes have individuals who engage in ethics
      consultation, and most do so with very little, if any, training. The goal of this
      article is not to advance the scholarly literature on training clinical ethics
      consultants, but instead to provide a road map for individuals doing ethics
      consultation who would like more training. In this way, I hope to advance the
      field in some small way, by educating, empowering, and encouraging small- to
      medium-sized hospitals to train the members of their ethics committee who engage 
      in ethics consultation.
FAU - Volpe, Rebecca L
AU  - Volpe RL
AD  - Penn State College of Medicine Department of Humanities, USA. rvolpe@hmc.psu.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
MH  - Congresses as Topic
MH  - Education/methods/trends
MH  - *Education, Continuing/methods/organization & administration/trends
MH  - Ethicists/*education
MH  - Ethics Committees, Clinical
MH  - *Ethics Consultation/ethics/standards/trends
MH  - Ethics, Clinical/*education
MH  - Humans
MH  - Inservice Training/methods/trends
MH  - Learning
MH  - *Negotiating/methods
MH  - Pennsylvania
MH  - *Programmed Instructions as Topic/trends
MH  - Surveys and Questionnaires
MH  - Teaching/methods/trends
MH  - United States
EDAT- 2011/12/16 06:00
MHDA- 2012/01/11 06:00
CRDT- 2011/12/16 06:00
PHST- 2011/12/16 06:00 [entrez]
PHST- 2011/12/16 06:00 [pubmed]
PHST- 2012/01/11 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2011 Fall;22(3):217-22.


PMID- 22167982
OWN - NLM
STAT- MEDLINE
DCOM- 20120110
LR  - 20111215
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 22
IP  - 3
DP  - 2011 Fall
TI  - Ethical challenges when patients have dementia.
PG  - 203-11
AB  - Dementia is among the most terrible diseases humans can have. Of all of the
      things that careproviders could do to enhance the quality of life that persons
      with dementia have, which ones should they do?
FAU - Howe, Edmund G
AU  - Howe EG
AD  - Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
RN  - 0 (Antipsychotic Agents)
SB  - IM
MH  - Advance Directives
MH  - Aggression
MH  - Alzheimer Disease/*nursing/psychology
MH  - Antipsychotic Agents/administration & dosage
MH  - Caregivers/*ethics/psychology/*standards
MH  - Coitus
MH  - Deception
MH  - Dementia/nursing
MH  - Disease Progression
MH  - Ethics, Nursing
MH  - Humans
MH  - *Interpersonal Relations
MH  - Moral Obligations
MH  - Psychomotor Performance
MH  - *Quality of Life
MH  - Rape/prevention & control
EDAT- 2011/12/16 06:00
MHDA- 2012/01/11 06:00
CRDT- 2011/12/16 06:00
PHST- 2011/12/16 06:00 [entrez]
PHST- 2011/12/16 06:00 [pubmed]
PHST- 2012/01/11 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2011 Fall;22(3):203-11.


PMID- 22067926
OWN - NLM
STAT- MEDLINE
DCOM- 20120404
LR  - 20120910
IS  - 1529-7535 (Print)
IS  - 1529-7535 (Linking)
VI  - 12
IP  - 6 Suppl
DP  - 2011 Nov
TI  - Ethical issues in pediatric emergency mass critical care.
PG  - S163-8
LID - 10.1097/PCC.0b013e318234a88b [doi]
AB  - INTRODUCTION: As a result of recent events, including natural disasters and
      pandemics, mass critical care planning has become a priority. In general,
      planning involves limiting the scope of disasters, increasing the supply of
      medical resources, and allocating scarce resources. Entities at varying levels
      have articulated ethical frameworks to inform policy development. In spite of
      this increased focus, children have received limited attention. Children require 
      special attention because of their unique vulnerabilities and needs. METHODS: In 
      May 2008, the Task Force for Mass Critical Care published guidance on provision
      of mass critical care to adults. Acknowledging that the critical care needs of
      children during disasters were unaddressed by this effort, a 17-member Steering
      Committee, assembled by the Oak Ridge Institute for Science and Education with
      guidance from members of the American Academy of Pediatrics, convened in April
      2009 to determine priority topic areas for pediatric emergency mass critical care
      recommendations.Steering Committee members established subgroups by topic area
      and performed literature reviews of MEDLINE and Ovid databases. Draft documents
      were subsequently developed and revised based on the feedback from the Task
      Force. The Pediatric Emergency Mass Critical Care Task Force, composed of 36
      experts from diverse public health, medical, and disaster response fields,
      convened in Atlanta, GA, on March 29-30, 2010. This document reflects expert
      input from the Task Force in addition to the most current medical literature.
      TASK FORCE RECOMMENDATIONS: The Ethics Subcommittee recommends that surge
      planning seek to provide resources for children in proportion to their percentage
      of the population or preferably, if data are available, the percentage of those
      affected by the disaster. Generally, scarce resources should be allocated on the 
      basis of need, benefit, and the conservation of resources. Estimates of need,
      benefit, and resource utilization may be more subjective or objective. While the 
      Subcommittee favors more objective methods, pediatrics lacks a simple, validated 
      scoring system to predict benefit or resource utilization. The Subcommittee
      hesitantly recommends relying on expert opinion while pediatric triage tools are 
      developed. If resources remain inadequate, they should then be allocated based on
      queuing or lottery. Choosing between these methods is based on ethical,
      psychological, and practical considerations upon which the Subcommittee could not
      reach consensus. The Subcommittee unanimously believes the proposal to favor
      individuals between 15 and 40 yrs of age is inappropriate. Other age-based
      criteria and criteria based on social role remain controversial. The Subcommittee
      recommends continued work to engage all stakeholders, especially the public, in
      deliberation about these issues.
FAU - Antommaria, Armand H Matheny
AU  - Antommaria AH
AD  - University of Utah School of Medicine, Salt Lake City, UT, USA.
      Armand.Antommaria@hsc.utah.edu
FAU - Powell, Tia
AU  - Powell T
FAU - Miller, Jennifer E
AU  - Miller JE
FAU - Christian, Michael D
AU  - Christian MD
CN  - Task Force for Pediatric Emergency Mass Critical Care
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Pediatr Crit Care Med
JT  - Pediatric critical care medicine : a journal of the Society of Critical Care
      Medicine and the World Federation of Pediatric Intensive and Critical Care
      Societies
JID - 100954653
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Disaster Planning
MH  - Emergency Medical Services/*ethics
MH  - Health Planning Councils
MH  - Health Planning Guidelines
MH  - Health Services Needs and Demand
MH  - Humans
MH  - Infant
MH  - *Mass Casualty Incidents
MH  - Triage
MH  - United States
IR  - Adirim T
FIR - Adirim, Terry
IR  - Anderson M
FIR - Anderson, Michael
IR  - Argent A
FIR - Argent, Andrew
IR  - Antommaria AH
FIR - Antommaria, Armand H
IR  - Baum C
FIR - Baum, Carl
IR  - Blake N
FIR - Blake, Nancy
IR  - Bohn D
FIR - Bohn, Desmond
IR  - Braner D
FIR - Braner, Dana
IR  - Brinker D
FIR - Brinker, Debbie
IR  - Broselow J
FIR - Broselow, James
IR  - Burkle F
FIR - Burkle, Frederick
IR  - Burns J
FIR - Burns, Jeffrey
IR  - Christian MD
FIR - Christian, Michael D
IR  - Chung S
FIR - Chung, Sarita
IR  - Conway EE Jr
FIR - Conway, Edward E Jr
IR  - Cooper A
FIR - Cooper, Arthur
IR  - Donn S
FIR - Donn, Steven
IR  - Garrett AL
FIR - Garrett, Andrew L
IR  - Gausche-Hill M
FIR - Gausche-Hill, Marianne
IR  - Geiling J
FIR - Geiling, James
IR  - Gougelet R
FIR - Gougelet, Robert
IR  - Kanter RK
FIR - Kanter, Robert K
IR  - Kissoon N
FIR - Kissoon, Niranjan
IR  - Krug SE
FIR - Krug, Steven E
IR  - Lu D
FIR - Lu, Downing
IR  - Luten R
FIR - Luten, Robert
IR  - Meyer MT
FIR - Meyer, Michael T
IR  - Miller JE
FIR - Miller, Jennifer E
IR  - Poss WB
FIR - Poss, W Bradley
IR  - Powell T
FIR - Powell, Tia
IR  - Siegel D
FIR - Siegel, Dave
IR  - Sirbaugh P
FIR - Sirbaugh, Paul
IR  - Tegtmeyer K
FIR - Tegtmeyer, Ken
IR  - Toltzis P
FIR - Toltzis, Philip
IR  - Vernon DD
FIR - Vernon, Donald D
IR  - Upperman JS
FIR - Upperman, Jeffrey S
EDAT- 2011/12/16 06:00
MHDA- 2012/04/05 06:00
CRDT- 2011/11/10 06:00
PHST- 2011/11/10 06:00 [entrez]
PHST- 2011/12/16 06:00 [pubmed]
PHST- 2012/04/05 06:00 [medline]
AID - 10.1097/PCC.0b013e318234a88b [doi]
AID - 00130478-201111001-00009 [pii]
PST - ppublish
SO  - Pediatr Crit Care Med. 2011 Nov;12(6 Suppl):S163-8. doi:
      10.1097/PCC.0b013e318234a88b.


PMID- 22167386
OWN - NLM
STAT- MEDLINE
DCOM- 20120524
LR  - 20120322
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 4
DP  - 2012 Apr
TI  - Ethics requirements and impact factor.
PG  - 253-5
LID - 10.1136/medethics-2011-100174 [doi]
AB  - Do all clinical research publications show strong application of ethics
      principles and respect for biomedical law? We examined, for the year 2009, the
      ethics requirements displayed on the website of 30 leading medical journals with 
      an impact factor (IF) >10, and 30 others with an IF <10. We carried out a short
      study looking at the relationship between the IF of a journal and the ethics
      requirements in its instructions to authors. We show that the IF of a biomedical 
      journal bears a direct relationship to its ethics requirements. Such results
      should improve the ethics requirements of all biomedical journals, especially
      those with low IF, so that they are internationally standardised to the higher
      standard required by journals with higher IF.
FAU - Charlier, Philippe
AU  - Charlier P
AD  - Department of Medical Ethicsand Legal Medicine, University Paris 5, 45
      Saints-Pe`res street, F-75005 Paris, France. ph_charlier@yahoo.fr
FAU - Bridoux, Valerie
AU  - Bridoux V
FAU - Watier, Laurence
AU  - Watier L
FAU - Menetrier, Melissa
AU  - Menetrier M
FAU - de la Grandmaison, Geoffroy Lorin
AU  - de la Grandmaison GL
FAU - Herve, Christian
AU  - Herve C
LA  - eng
PT  - Journal Article
DEP - 20111213
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Biomedical Research/*ethics/*legislation & jurisprudence
MH  - Editorial Policies
MH  - Humans
MH  - *Journal Impact Factor
EDAT- 2011/12/15 06:00
MHDA- 2012/05/25 06:00
CRDT- 2011/12/15 06:00
PHST- 2011/12/15 06:00 [entrez]
PHST- 2011/12/15 06:00 [pubmed]
PHST- 2012/05/25 06:00 [medline]
AID - medethics-2011-100174 [pii]
AID - 10.1136/medethics-2011-100174 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Apr;38(4):253-5. doi: 10.1136/medethics-2011-100174. Epub 2011
      Dec 13.


PMID- 22167385
OWN - NLM
STAT- MEDLINE
DCOM- 20120524
LR  - 20161125
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 4
DP  - 2012 Apr
TI  - Development of clinical ethics services in the UK: a national survey.
PG  - 210-4
LID - 10.1136/medethics-2011-100173 [doi]
AB  - BACKGROUND: In 2001 a report on the provision of clinical ethics support in UK
      healthcare institutions identified 20 clinical ethics committees. Since then
      there has been no systematic evaluation or documentation of their work at a
      national level. Recent national surveys of clinical ethics services in other
      countries have identified wide variation in practice and scope of activities.
      OBJECTIVE: To describe the current provision of ethics support in the UK and its 
      development since 2001. METHOD: A postal/electronic questionnaire survey
      administered to the chairs of all 82 clinical ethics services registered with the
      UK Clinical Ethics Network in July 2010. RESULTS: Response rate was 62% with the 
      majority of responding services situated in acute trusts. All services included a
      clinical ethics committee with one service also having a clinical ethicist. Lay
      members were present in 72% of responding committees. Individual case
      consultation has increased since 2001 with 29% of chairs spending more than 50%
      of their time on this. Access to and involvement in the process of case
      consultation is less for patients and families than for clinical staff. There is 
      wide variation in committee processes and levels of institutional support. Over
      half of the responding committees undertook some form of evaluation. CONCLUSION: 
      Clinical ethics services in the UK are increasing as is their involvement in case
      consultation. However, the significant variation in committee processes suggests 
      that further qualitative research is needed to understand how these committees
      function and the role they play in their institution.
FAU - Slowther, Anne Marie
AU  - Slowther AM
AD  - Warwick Medical School, University of Warwick, Coventry, CV4 7AL, UK.
      a-m.slowther@warwick.ac.uk
FAU - McClimans, Leah
AU  - McClimans L
FAU - Price, Charlotte
AU  - Price C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111213
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Data Collection
MH  - Ethics Committees, Clinical/*organization & administration/*standards
MH  - Health Services Research/*ethics
MH  - Humans
MH  - Qualitative Research
MH  - United Kingdom
EDAT- 2011/12/15 06:00
MHDA- 2012/05/25 06:00
CRDT- 2011/12/15 06:00
PHST- 2011/12/15 06:00 [entrez]
PHST- 2011/12/15 06:00 [pubmed]
PHST- 2012/05/25 06:00 [medline]
AID - medethics-2011-100173 [pii]
AID - 10.1136/medethics-2011-100173 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Apr;38(4):210-4. doi: 10.1136/medethics-2011-100173. Epub 2011
      Dec 13.


PMID- 22167028
OWN - NLM
STAT- MEDLINE
DCOM- 20120511
LR  - 20220321
IS  - 1880-4926 (Electronic)
IS  - 1343-4934 (Linking)
VI  - 53
IP  - 4
DP  - 2011 Dec
TI  - Asymptomatic radiopaque lesions of the jaws: a radiographic study using cone-beam
      computed tomography.
PG  - 439-44
AB  - Panoramic radiography and cone-beam computed tomography (CT) were used to analyze
      asymptomatic radiopaque lesions in the jaw bones and determine the diagnostic
      relevance of the lesions based on their relationships to teeth and site of
      origin. One hundred radiopaque lesions detected between 1998 and 2002 were
      examined by both panoramic radiography and cone-beam CT. On the basis of
      panoramic radiographs, the region was classified as periapical, body, or
      edentulous, and the site was classified as molar or premolar. Follow-up data from
      medical records were available for only 36 of these cases. The study protocol for
      simultaneous use of cone-beam CT was approved by the ethics review board of our
      institution. A large majority of radiopaque lesions were observed in premolar and
      molar sites of the mandible; 60% of lesions were periapical, 24% were in the
      body, and 16% were in the edentulous region. An interesting type of radiopaque
      lesion, which we named a pearl shell structure (PSS), was observed on cone-beam
      CT in 34 of the 100 lesions. The PSS is a distinctive structure, and this finding
      on cone-beam CT likely represents the start of bone formation before bone
      sclerosis.
FAU - Araki, Masao
AU  - Araki M
AD  - Department of Oral and Maxillofacial Radiology, Nihon University School of
      Dentistry, Tokyo, Japan. araki-m@dent.nihon-u.ac.jp
FAU - Matsumoto, Naoyuki
AU  - Matsumoto N
FAU - Matsumoto, Kunihito
AU  - Matsumoto K
FAU - Ohnishi, Masaaki
AU  - Ohnishi M
FAU - Honda, Kazuya
AU  - Honda K
FAU - Komiyama, Kazuo
AU  - Komiyama K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - J Oral Sci
JT  - Journal of oral science
JID - 9808942
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Asymptomatic Diseases
MH  - Chi-Square Distribution
MH  - Child
MH  - Cone-Beam Computed Tomography
MH  - Female
MH  - Humans
MH  - Jaw/*diagnostic imaging
MH  - Jaw Diseases/*diagnostic imaging
MH  - Jaw, Edentulous/diagnostic imaging
MH  - Male
MH  - Mandibular Diseases/diagnostic imaging
MH  - Maxillary Diseases/diagnostic imaging
MH  - Middle Aged
MH  - Osteomyelitis/diagnostic imaging
MH  - Osteosclerosis/*diagnostic imaging
MH  - Periapical Diseases/diagnostic imaging
MH  - Radiography, Panoramic
MH  - Retrospective Studies
MH  - Young Adult
EDAT- 2011/12/15 06:00
MHDA- 2012/05/12 06:00
CRDT- 2011/12/15 06:00
PHST- 2011/12/15 06:00 [entrez]
PHST- 2011/12/15 06:00 [pubmed]
PHST- 2012/05/12 06:00 [medline]
AID - JST.JSTAGE/josnusd/53.439 [pii]
AID - 10.2334/josnusd.53.439 [doi]
PST - ppublish
SO  - J Oral Sci. 2011 Dec;53(4):439-44. doi: 10.2334/josnusd.53.439.


PMID- 22166262
OWN - NLM
STAT- MEDLINE
DCOM- 20120612
LR  - 20220316
IS  - 1523-5866 (Electronic)
IS  - 1522-8517 (Linking)
VI  - 14
IP  - 3
DP  - 2012 Mar
TI  - Stem cells as therapeutic vehicles for the treatment of high-grade gliomas.
PG  - 256-65
LID - 10.1093/neuonc/nor204 [doi]
AB  - Stem cells have generated great interest in the past decade as potential tools
      for cell-based treatment of human high-grade gliomas. Thus far, 3 types of stem
      cells have been tested as vehicles for various therapeutic agents: embryonic,
      neural, and mesenchymal. The types of therapeutic approaches and/or agents
      examined in the context of stem cell-based delivery include cytokines,
      enzyme/prodrug suicide combinations, viral particles, matrix metalloproteinases, 
      and antibodies. Each strategy has specific advantages and disadvantages.
      Irrespective of the source and/or type of stem cell, there are several areas of
      concern for their translation to the clinical setting, such as migration in the
      adult human brain, potential teratogenesis, immune rejection, and regulatory and 
      ethical issues. Nonetheless, a clinical trial is under way using neural stem
      cell-based delivery of an enzyme/prodrug suicide combination for recurrent
      high-grade glioma. A proposed future direction could encompass the use of stem
      cells as vehicles for delivery of agents targeting glioma stem cells, which have 
      been implicated in the resistance of high-grade glioma to treatment. Overall,
      stem cells are providing an unprecedented opportunity for cell-based approaches
      in the treatment of high-grade gliomas, which have a persistently dismal
      prognosis and mandate a continued search for therapeutic options.
FAU - Binello, Emanuela
AU  - Binello E
AD  - Department of Neurosurgery, Mount Sinai School of Medicine, 1 Gustave L. Levy
      Place, Box 1136, New York, NY 10029, USA.
FAU - Germano, Isabelle M
AU  - Germano IM
LA  - eng
GR  - R01 CA129489/CA/NCI NIH HHS/United States
GR  - R01 CA129489-01A1/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20111213
PL  - England
TA  - Neuro Oncol
JT  - Neuro-oncology
JID - 100887420
RN  - 0 (Cytokines)
RN  - 0 (Prodrugs)
SB  - IM
MH  - Brain/physiopathology/virology
MH  - Brain Neoplasms/*therapy
MH  - Cytokines/genetics
MH  - Embryonic Stem Cells/metabolism
MH  - Genetic Therapy
MH  - Glioma/*therapy
MH  - Humans
MH  - Mesenchymal Stem Cells/metabolism
MH  - Neural Stem Cells/metabolism
MH  - Prodrugs/administration & dosage
MH  - *Stem Cell Transplantation
MH  - Stem Cells/metabolism
PMC - PMC3280798
EDAT- 2011/12/15 06:00
MHDA- 2012/06/13 06:00
CRDT- 2011/12/15 06:00
PHST- 2011/12/15 06:00 [entrez]
PHST- 2011/12/15 06:00 [pubmed]
PHST- 2012/06/13 06:00 [medline]
AID - nor204 [pii]
AID - 10.1093/neuonc/nor204 [doi]
PST - ppublish
SO  - Neuro Oncol. 2012 Mar;14(3):256-65. doi: 10.1093/neuonc/nor204. Epub 2011 Dec 13.


PMID- 22166168
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20220309
IS  - 1472-698X (Electronic)
IS  - 1472-698X (Linking)
VI  - 11 Suppl 2
DP  - 2011 Nov 8
TI  - Comparing antiretroviral treatment outcomes between a prospective community-based
      and hospital-based cohort of HIV patients in rural Uganda.
PG  - S12
LID - 10.1186/1472-698X-11-S2-S12 [doi]
AB  - BACKGROUND: Improved availability of antiretroviral therapy in sub-Saharan Africa
      is intended to benefit all eligible HIV-infected patients; however in reality
      antiretroviral services are mainly offered in urban hospitals. Poor rural
      patients have difficulty accessing the drugs, making the provision of
      antiretroviral therapy inequitable. Initial tests of community-based treatment
      programs in Uganda suggest that home-based treatment of HIV/AIDS may equal
      hospital-based treatment; however the literature reveals limited experiences with
      such programs. THE RESEARCH: This intervention study aimed to; 1) assess the
      effectiveness of a rural community-based ART program in a subcounty (Rwimi) of
      Uganda; and 2) compare treatment outcomes and mortality in a rural
      community-based antiretroviral therapy program with a well-established
      hospital-based program. Ethics approvals were obtained in Canada and Uganda.
      RESULTS AND OUTCOMES: Successful treatment outcomes after two years in both the
      community and hospital cohorts were high. All-cause mortality was similar in both
      cohorts. However, community-based patients were more likely to achieve viral
      suppression and had good adherence to treatment. The community-based program was 
      slightly more cost-effective. Per capita costs in both settings were
      unsustainable, representing more than Uganda's Primary Health Care Services
      current expenditures per person per year for all health services. The unpaid
      community volunteers showed high participation and low attrition rates for the
      two years that this program was evaluated. CHALLENGES AND SUCCESSES: Key
      successes of this study include the demonstration that antiretroviral therapy can
      be provided in a rural setting, the creation of a research infrastructure and
      culture within Kabarole's health system, and the establishment of a research
      collaboration capable of enriching the global health graduate program at the
      University of Alberta. Challenging questions about the long-term feasibility and 
      sustainability of a community-based ARV program in Uganda still remain. THE
      PARTNERSHIP: This project is a continuation of previous successful collaborations
      between the School of Public Health of Makerere University, the School of Public 
      Health of University of Alberta, the Kabarole District Administration and the
      Kabarole Research and Resource Center.
FAU - Kipp, Walter
AU  - Kipp W
AD  - School of Public Health, University of Alberta, 3-50 University Terrace, 8303-112
      Street, Edmonton, AB, Canada, T6G 2T4. walter.kipp@ualberta.ca.
FAU - Konde-Lule, Joseph
AU  - Konde-Lule J
FAU - Rubaale, Tom
AU  - Rubaale T
FAU - Okech-Ojony, Joa
AU  - Okech-Ojony J
FAU - Alibhai, Arif
AU  - Alibhai A
FAU - Saunders, Duncan L
AU  - Saunders DL
LA  - eng
PT  - Journal Article
DEP - 20111108
PL  - England
TA  - BMC Int Health Hum Rights
JT  - BMC international health and human rights
JID - 101088678
PMC - PMC3247832
EDAT- 2011/12/15 06:00
MHDA- 2011/12/15 06:01
CRDT- 2011/12/15 06:00
PHST- 2011/12/15 06:00 [entrez]
PHST- 2011/12/15 06:00 [pubmed]
PHST- 2011/12/15 06:01 [medline]
AID - 1472-698X-11-S2-S12 [pii]
AID - 10.1186/1472-698X-11-S2-S12 [doi]
PST - epublish
SO  - BMC Int Health Hum Rights. 2011 Nov 8;11 Suppl 2:S12. doi:
      10.1186/1472-698X-11-S2-S12.


PMID- 22166001
OWN - NLM
STAT- MEDLINE
DCOM- 20120517
LR  - 20211021
IS  - 1475-2875 (Electronic)
IS  - 1475-2875 (Linking)
VI  - 10
DP  - 2011 Dec 13
TI  - Impact of combining intermittent preventive treatment with home management of
      malaria in children less than 10 years in a rural area of Senegal: a cluster
      randomized trial.
PG  - 358
LID - 10.1186/1475-2875-10-358 [doi]
AB  - BACKGROUND: Current malaria control strategies recommend (i) early case detection
      using rapid diagnostic tests (RDT) and treatment with artemisinin combination
      therapy (ACT), (ii) pre-referral rectal artesunate, (iii) intermittent preventive
      treatment and (iv) impregnated bed nets. However, these individual malaria
      control interventions provide only partial protection in most epidemiological
      situations. Therefore, there is a need to investigate the potential benefits of
      integrating several malaria interventions to reduce malaria prevalence and
      morbidity. METHODS: A randomized controlled trial was carried out to assess the
      impact of combining seasonal intermittent preventive treatment in children (IPTc)
      with home-based management of malaria (HMM) by community health workers (CHWs) in
      Senegal. Eight CHWs in eight villages covered by the Bonconto health post, (South
      Eastern part of Senegal) were trained to diagnose malaria using RDT, provide
      prompt treatment with artemether-lumefantrine for uncomplicated malaria cases and
      pre-referral rectal artesunate for complicated malaria occurring in children
      under 10 years. Four CHWs were randomized to also administer monthly IPTc as
      single dose of sulphadoxine-pyrimethamine (SP) plus three doses of amodiaquine
      (AQ) in the malaria transmission season, October and November 2010. Primary end
      point was incidence of single episode of malaria attacks over 8 weeks of follow
      up. Secondary end points included prevalence of malaria parasitaemia, and
      prevalence of anaemia at the end of the transmission season. Primary analysis was
      by intention to treat. The study protocol was approved by the Senegalese National
      Ethical Committee (approval 0027/MSP/DS/CNRS, 18/03/2010). RESULTS: A total of
      1,000 children were enrolled. The incidence of malaria episodes was 7.1/100 child
      months at risk [95% CI (3.7-13.7)] in communities with IPTc + HMM compared to
      35.6/100 child months at risk [95% CI (26.7-47.4)] in communities with only HMM
      (aOR = 0.20; 95% CI 0.09-0.41; p = 0.04). At the end of the transmission season, 
      malaria parasitaemia prevalence was lower in communities with IPTc + HMM (2.05%
      versus 4.6% p = 0.03). Adjusted for age groups, sex, Plasmodium falciparum
      carriage and prevalence of malnutrition, IPTc + HMM showed a significant
      protective effect against anaemia (aOR = 0.59; 95% CI 0.42-0.82; p = 0.02).
      CONCLUSION: Combining IPTc and HMM can provide significant additional benefit in 
      preventing clinical episodes of malaria as well as anaemia among children in
      Senegal.
FAU - Tine, Roger C K
AU  - Tine RC
AD  - Service de Parasitologie, Faculte de Medecine et Pharmacie, Dakar, Senegal.
      rogertine@hotmail.com
FAU - Faye, Babacar
AU  - Faye B
FAU - Ndour, Cheikh T
AU  - Ndour CT
FAU - Ndiaye, Jean L
AU  - Ndiaye JL
FAU - Ndiaye, Magatte
AU  - Ndiaye M
FAU - Bassene, Charlemagne
AU  - Bassene C
FAU - Magnussen, Pascal
AU  - Magnussen P
FAU - Bygbjerg, Ib C
AU  - Bygbjerg IC
FAU - Sylla, Khadim
AU  - Sylla K
FAU - Ndour, Jacques D
AU  - Ndour JD
FAU - Gaye, Oumar
AU  - Gaye O
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20111213
PL  - England
TA  - Malar J
JT  - Malaria journal
JID - 101139802
RN  - 0 (Artemether, Lumefantrine Drug Combination)
RN  - 0 (Artemisinins)
RN  - 0 (Drug Combinations)
RN  - 0 (Ethanolamines)
RN  - 0 (Fluorenes)
RN  - 220236ED28 (Amodiaquine)
RN  - 37338-39-9 (fanasil, pyrimethamine drug combination)
RN  - 60W3249T9M (Artesunate)
RN  - 88463U4SM5 (Sulfadoxine)
RN  - Z3614QOX8W (Pyrimethamine)
SB  - IM
MH  - Amodiaquine/administration & dosage/therapeutic use
MH  - Anemia/drug therapy/parasitology/prevention & control
MH  - Animals
MH  - Artemether, Lumefantrine Drug Combination
MH  - Artemisinins/administration & dosage/therapeutic use
MH  - Artesunate
MH  - Child
MH  - Child, Preschool
MH  - *Community Health Workers
MH  - *Disease Management
MH  - Drug Combinations
MH  - Ethanolamines/administration & dosage/therapeutic use
MH  - Female
MH  - Fluorenes/administration & dosage/therapeutic use
MH  - Follow-Up Studies
MH  - Health Promotion
MH  - Humans
MH  - Infant
MH  - Malaria, Falciparum/diagnosis/epidemiology/*prevention & control
MH  - Male
MH  - Parasitemia/epidemiology/prevention & control
MH  - Plasmodium falciparum/pathogenicity
MH  - Prevalence
MH  - Preventive Health Services/*methods/statistics & numerical data
MH  - Pyrimethamine/administration & dosage/therapeutic use
MH  - Rural Population
MH  - Seasons
MH  - Senegal/epidemiology
MH  - Sulfadoxine/administration & dosage/therapeutic use
PMC - PMC3286438
EDAT- 2011/12/15 06:00
MHDA- 2012/05/18 06:00
CRDT- 2011/12/15 06:00
PHST- 2011/08/18 00:00 [received]
PHST- 2011/12/13 00:00 [accepted]
PHST- 2011/12/15 06:00 [entrez]
PHST- 2011/12/15 06:00 [pubmed]
PHST- 2012/05/18 06:00 [medline]
AID - 1475-2875-10-358 [pii]
AID - 10.1186/1475-2875-10-358 [doi]
PST - epublish
SO  - Malar J. 2011 Dec 13;10:358. doi: 10.1186/1475-2875-10-358.


PMID- 22165989
OWN - NLM
STAT- MEDLINE
DCOM- 20120518
LR  - 20211021
IS  - 1471-2288 (Electronic)
IS  - 1471-2288 (Linking)
VI  - 11
DP  - 2011 Dec 13
TI  - Being a quantitative interviewer: qualitatively exploring interviewers'
      experiences in a longitudinal cohort study.
PG  - 165
LID - 10.1186/1471-2288-11-165 [doi]
AB  - BACKGROUND: Many studies of health outcomes rely on data collected by
      interviewers administering highly-structured (quantitative) questionnaires to
      participants. Little appears to be known about the experiences of such
      interviewers. This paper explores interviewer experiences of working on a
      longitudinal study in New Zealand (the Prospective Outcomes of injury
      Study--POIS). Interviewers administer highly-structured questionnaires to
      participants, usually by telephone, and enter data into a secure computer
      program. The research team had expectations of interviewers including: consistent
      questionnaire administration, timeliness, proportions of potential participants
      recruited and an empathetic communication style. This paper presents results of a
      focus group to qualitatively explore with the team of interviewers their
      experiences, problems encountered, strategies, support systems used and training.
      METHODS: A focus group with interviewers involved in the POIS interviews was
      held; it was audio-recorded and transcribed. The analytical method was thematic, 
      with output intended to be descriptive and interpretive. RESULTS: Nine
      interviewers participated in the focus group (average time in interviewer role
      was 31 months). Key themes were: 1) the positive aspects of the quantitative
      interviewer role (i.e. relationships and resilience, insights gained, and
      participants' feedback), 2) difficulties interviewers encountered and solutions
      identified (i.e. stories lost or incomplete, forgotten appointments, telling the 
      stories, acknowledging distress, stories reflected and debriefing and support),
      and 3) meeting POIS researcher expectations (i.e. performance standards,
      time-keeping, dealing exclusively with the participant and maintaining privacy). 
      CONCLUSIONS: Interviewers demonstrated great skill in the way they negotiated
      research team expectations whilst managing the relationships with participants.
      Interviewers found it helpful to have a research protocol in place in the event
      of sensitive situations--this appeared to alleviate the pressure on interviewers 
      to carry the burden of responsibility. Interviewers are employed to
      scientifically gather quantitative data, yet their effectiveness relies largely
      on their humanity. We propose that the personal connection generated between the 
      interviewers and participants was important, and enabled successful follow-up
      rates for the study. The enjoyment of these relationships was crucial to
      interviewers and helped balance the negative aspects of their role. Our results
      suggest that experienced quantitative interviewers endeavour, as do many
      qualitative researchers, to carefully and respectfully negotiate the requirements
      of the interview within a relationship they form with participants: being
      sensitive to the needs of participants and respectful of their wishes--and
      establishing an ethical relationship.
FAU - Derrett, Sarah
AU  - Derrett S
AD  - Injury Prevention Research Unit, Department of Preventive and Social Medicine,
      University of Otago, Dunedin, New Zealand. sarah.derrett@otago.ac.nz
FAU - Colhoun, Sarah
AU  - Colhoun S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111213
PL  - England
TA  - BMC Med Res Methodol
JT  - BMC medical research methodology
JID - 100968545
SB  - IM
MH  - Anecdotes as Topic
MH  - Clinical Competence
MH  - Disabled Persons
MH  - Feedback
MH  - Focus Groups
MH  - Humans
MH  - Interpersonal Relations
MH  - *Interviews as Topic
MH  - Longitudinal Studies
MH  - New Zealand
MH  - Outcome Assessment, Health Care/*methods
MH  - Professional Role
MH  - Prospective Studies
MH  - *Qualitative Research
MH  - Research Personnel/*psychology/standards
MH  - Social Support
MH  - Stress, Psychological
MH  - Surveys and Questionnaires
MH  - Time Management
MH  - Wounds and Injuries/classification/psychology/therapy
PMC - PMC3266203
EDAT- 2011/12/15 06:00
MHDA- 2012/05/19 06:00
CRDT- 2011/12/15 06:00
PHST- 2011/09/27 00:00 [received]
PHST- 2011/12/13 00:00 [accepted]
PHST- 2011/12/15 06:00 [entrez]
PHST- 2011/12/15 06:00 [pubmed]
PHST- 2012/05/19 06:00 [medline]
AID - 1471-2288-11-165 [pii]
AID - 10.1186/1471-2288-11-165 [doi]
PST - epublish
SO  - BMC Med Res Methodol. 2011 Dec 13;11:165. doi: 10.1186/1471-2288-11-165.


PMID- 22165531
OWN - NLM
STAT- MEDLINE
DCOM- 20111220
LR  - 20111214
IS  - 0023-7205 (Print)
IS  - 0023-7205 (Linking)
VI  - 108
IP  - 42
DP  - 2011 Oct 19-25
TI  - [Ethical approval should be given for research concerning severely ill elderly].
PG  - 2072-3
FAU - Ekerstad, Niklas
AU  - Ekerstad N
AD  - Kardiologkliniken, NU-sjukhuset, Trollhattan-Uddevalla. niklas.ekerstad@liu.se
LA  - swe
PT  - Journal Article
TT  - Etiskt tillstand bor ges for forskning pa svart sjuka aldre.
PL  - Sweden
TA  - Lakartidningen
JT  - Lakartidningen
JID - 0027707
SB  - IM
MH  - Aged
MH  - Critical Illness
MH  - Ethics Committees, Research
MH  - *Ethics, Research
MH  - Evidence-Based Medicine
MH  - Frail Elderly
MH  - *Geriatrics
MH  - Humans
MH  - Informed Consent/ethics
MH  - Randomized Controlled Trials as Topic/*ethics
EDAT- 2011/12/15 06:00
MHDA- 2011/12/21 06:00
CRDT- 2011/12/15 06:00
PHST- 2011/12/15 06:00 [entrez]
PHST- 2011/12/15 06:00 [pubmed]
PHST- 2011/12/21 06:00 [medline]
PST - ppublish
SO  - Lakartidningen. 2011 Oct 19-25;108(42):2072-3.


PMID- 22165404
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20191112
IS  - 0102-6933 (Print)
IS  - 0102-6933 (Linking)
VI  - 32
IP  - 3
DP  - 2011 Sep
TI  - [People with venous ulcers: a study of the psychosocial aspects of the Roy
      Adaptation Model].
PG  - 561-8
AB  - A transversal descriptive quantitative study, conducted with 50 people with
      Venous Ulcer (VU) at an University Hospital, that aimed to ascertain the level of
      psychosocial adaptation of the Roy Model of people with VU. The study was
      approved by the Ethics Committee. The data were collected with a structured form.
      After organizing the data, composed of changes in the lives of people with VU, we
      classified it according to Roy's psychosocial aspects. We found that in the
      self-concept mode, 36% felt dissatisfied with physical appearance, and 18% had
      negative feelings; in the role-function mode: change in the working role (52.0%),
      housework (34.0%), marital (6.0%), leisure, pain, social, educational and
      transportation restrictions (82.0%); interdependence mode: support in treatment
      (82.0%), discrimination (58.0%). The identification of the psychosocial aspects
      directs nursing actions to consider the whole of the person receiving care in its
      relations with the environment, thus promoting a better level of adaptation.
FAU - Costa, Isabelle Katherinne Fernandes
AU  - Costa IK
AD  - Programa de Pos-Graduacao em Enfermagem da Universidade Federal do Rio Grande do 
      Norte (UFRN), Rio Grande do Norte, Brasil. isabellekfc@yahoo.com.br
FAU - da Nobrega, Walkiria Gomes
AU  - da Nobrega WG
FAU - Costa, Isabel Karolyne Fernandes
AU  - Costa IK
FAU - Torres, Gilson de Vasconcelos
AU  - Torres Gde V
FAU - Lira, Ana Luiza Brandao de Carvalho
AU  - Lira AL
FAU - Tourinho, Francis Solange Vieira
AU  - Tourinho FS
FAU - Enders, Bertha Cruz
AU  - Enders BC
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Pessoas com ulceras venosas: estudo do modo psicossocial do Modelo Adaptativo de 
      Roy.
PL  - Brazil
TA  - Rev Gaucha Enferm
JT  - Revista gaucha de enfermagem
JID - 8504882
MH  - *Adaptation, Psychological
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Models, Nursing
MH  - Varicose Ulcer/*psychology
EDAT- 2011/12/15 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/12/15 06:00
PHST- 2011/12/15 06:00 [entrez]
PHST- 2011/12/15 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - 10.1590/s1983-14472011000300018 [doi]
PST - ppublish
SO  - Rev Gaucha Enferm. 2011 Sep;32(3):561-8. doi: 10.1590/s1983-14472011000300018.


PMID- 22165396
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20191112
IS  - 0102-6933 (Print)
IS  - 0102-6933 (Linking)
VI  - 32
IP  - 3
DP  - 2011 Sep
TI  - [Cervical cancer: integral care to the woman in health services].
PG  - 502-8
AB  - This study aims to understand how the health services of the Brazilian Public
      Health System (BPHS) are organized to give an integral care to the woman with
      cervical cancer. This is a descriptive, qualitative research with 20 women.
      Semistructured interviews were coupled with participant observation in data
      collection. The thematic analysis revealed the theme: "The search for care:
      access to BPHS and use of health services in the search for integral care". In
      the use of health services, women have exposed their views on the received care, 
      and on the potentialities and limits of integrality in this context. The
      conclusion is that the effectivation of health actions that aim at the
      integrality of care for women requires courage and the promotion of a dialogue
      between social actors as a way to build a health awareness that allows an ethical
      commitment pointing towards the necessary changes in care.
FAU - Soares, Marilu Correa
AU  - Soares MC
AD  - Faculdade de Enfermagem da Universidade Federal de Pelotas (UFPel), Pelotas, Rio 
      Grande do Sul, Brasil.
FAU - Mishima, Silvana Martins
AU  - Mishima SM
FAU - da Silva, Renata Cunha
AU  - da Silva RC
FAU - Ribeiro, Caroline Vargas
AU  - Ribeiro CV
FAU - Meincke, Sonia Maria Konzgen
AU  - Meincke SM
FAU - Correa, Ana Candida Lopes
AU  - Correa AC
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Cancer de colo uterino: atencao integral a mulher nos servicos de saude.
PL  - Brazil
TA  - Rev Gaucha Enferm
JT  - Revista gaucha de enfermagem
JID - 8504882
MH  - Female
MH  - Humans
MH  - Uterine Cervical Neoplasms/*therapy
MH  - Women's Health Services/*standards
EDAT- 2011/12/15 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/12/15 06:00
PHST- 2011/12/15 06:00 [entrez]
PHST- 2011/12/15 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - 10.1590/s1983-14472011000300010 [doi]
PST - ppublish
SO  - Rev Gaucha Enferm. 2011 Sep;32(3):502-8. doi: 10.1590/s1983-14472011000300010.


PMID- 22165340
OWN - NLM
STAT- MEDLINE
DCOM- 20120103
LR  - 20190907
IS  - 1438-3276 (Print)
IS  - 1438-3276 (Linking)
VI  - 153
IP  - 47
DP  - 2011 Nov 24
TI  - [Treatment limits at the end of life: what is legally protected, what is
      ethically acceptable?].
PG  - 18
FAU - Stiefelhagen, Peter
AU  - Stiefelhagen P
LA  - ger
PT  - News
TT  - Therapiebegrenzung am Lebensende: Was ist rechtlich abgesichert, was ethisch
      vertretbar?
PL  - Germany
TA  - MMW Fortschr Med
JT  - MMW Fortschritte der Medizin
JID - 100893959
SB  - IM
MH  - Advance Directives/ethics/legislation & jurisprudence
MH  - *Ethics, Medical
MH  - Germany
MH  - Humans
MH  - Life Support Care/*ethics/*legislation & jurisprudence
MH  - Palliative Care/*ethics/*legislation & jurisprudence
MH  - Presumed Consent/ethics/legislation & jurisprudence
MH  - Terminal Care/*ethics/*legislation & jurisprudence
EDAT- 2011/12/15 06:00
MHDA- 2012/01/04 06:00
CRDT- 2011/12/15 06:00
PHST- 2011/12/15 06:00 [entrez]
PHST- 2011/12/15 06:00 [pubmed]
PHST- 2012/01/04 06:00 [medline]
AID - 10.1007/BF03369101 [doi]
PST - ppublish
SO  - MMW Fortschr Med. 2011 Nov 24;153(47):18. doi: 10.1007/BF03369101.


PMID- 22165302
OWN - NLM
STAT- MEDLINE
DCOM- 20120119
LR  - 20111213
IS  - 0883-5381 (Print)
IS  - 0883-5381 (Linking)
VI  - 26
IP  - 6
DP  - 2011 Nov-Dec
TI  - Ethics: a foundation for quality. A strong ethical framework helps determine
      organizational sucess.
PG  - 46, 48-9
FAU - Nelson, William A
AU  - Nelson WA
AD  - Dartmouth Institute for Health Policy and Clinical Practice, Dartmouth Medical
      School. william.a.nelson@dartmouth.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Healthc Exec
JT  - Healthcare executive
JID - 8612808
MH  - Delivery of Health Care/ethics
MH  - Efficiency, Organizational/*ethics
MH  - Health Facilities/*ethics
MH  - United States
EDAT- 2011/12/15 06:00
MHDA- 2012/01/20 06:00
CRDT- 2011/12/15 06:00
PHST- 2011/12/15 06:00 [entrez]
PHST- 2011/12/15 06:00 [pubmed]
PHST- 2012/01/20 06:00 [medline]
PST - ppublish
SO  - Healthc Exec. 2011 Nov-Dec;26(6):46, 48-9.


PMID- 22165266
OWN - NLM
STAT- MEDLINE
DCOM- 20120105
LR  - 20161021
IS  - 1712-624X (Print)
IS  - 1712-624X (Linking)
VI  - 15
IP  - 3
DP  - 2011 Oct
TI  - Global: health federation issues ethics guidelines on forced female
      sterilization.
PG  - 36-7
AB  - The International Federation of Gynaecology and Obstetrics (FIGO) recently
      released new ethics guidelines in response to the continuing forced sterilization
      of women, including those living with HIV, in parts of the developing world.
FAU - Arkin, Eli
AU  - Arkin E
AD  - Canadian HIV/AIDS Legal Network. earkin@aidslaw.ca
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - HIV AIDS Policy Law Rev
JT  - HIV/AIDS policy & law review
JID - 101249725
MH  - Female
MH  - *Guidelines as Topic
MH  - Humans
MH  - Intrauterine Devices
MH  - Pregnancy
MH  - Sterilization, Reproductive/*ethics
EDAT- 2011/12/15 06:00
MHDA- 2012/01/06 06:00
CRDT- 2011/12/15 06:00
PHST- 2011/12/15 06:00 [entrez]
PHST- 2011/12/15 06:00 [pubmed]
PHST- 2012/01/06 06:00 [medline]
PST - ppublish
SO  - HIV AIDS Policy Law Rev. 2011 Oct;15(3):36-7.


PMID- 22164951
OWN - NLM
STAT- MEDLINE
DCOM- 20111222
LR  - 20111212
IS  - 0017-7768 (Print)
IS  - 0017-7768 (Linking)
VI  - 150
IP  - 2
DP  - 2011 Feb
TI  - [Forecasting medical technologies--a global overview].
PG  - 185-9, 202
AB  - Forecasting new medical technologies is a crucial stage in the process of
      decision-making in health care systems on national, organizational, professional 
      and personal levels. Knowing what is on the horizon is essential. It is a tool
      facilitating preparedness and planning for updating health care in the western
      world. The challenge is to identify new promising technologies at an early stage.
      This is due to the uncertainty in estimating developing trends and consequences
      (clinical, financial, political, legal, social and ethical). A balance must be
      found between the desire to adopt new emerging technologies and the necessity for
      accountability n basing decisions on efficient evidence. Scarce resources,
      pervading health systems everywhere, emphasize the need for this mechanism to
      justify and improve health system determinations. Planning for the future has
      expanded into new medical fields, thereby reinforcing the importance of national 
      forecasting bodies. This article presents the basic terminology and principles of
      medical technology forecasting and reviews the agencies involved in early warning
      systems including Israel.
FAU - Tal, Orna
AU  - Tal O
AD  - Ministry of Health, Tel Hashomer. ornat@gertner.health.gov.il
LA  - heb
PT  - English Abstract
PT  - Journal Article
PL  - Israel
TA  - Harefuah
JT  - Harefuah
JID - 0034351
SB  - IM
MH  - Biomedical Technology/*trends
MH  - Decision Making, Organizational
MH  - *Forecasting
MH  - Humans
MH  - Israel
MH  - Technology Assessment, Biomedical/*methods/trends
EDAT- 2011/12/15 06:00
MHDA- 2011/12/23 06:00
CRDT- 2011/12/15 06:00
PHST- 2011/12/15 06:00 [entrez]
PHST- 2011/12/15 06:00 [pubmed]
PHST- 2011/12/23 06:00 [medline]
PST - ppublish
SO  - Harefuah. 2011 Feb;150(2):185-9, 202.


PMID- 22164947
OWN - NLM
STAT- MEDLINE
DCOM- 20111222
LR  - 20111212
IS  - 0017-7768 (Print)
IS  - 0017-7768 (Linking)
VI  - 150
IP  - 2
DP  - 2011 Feb
TI  - [Public financing for off-label use of drugs].
PG  - 163-7, 204
AB  - Off-label use of drugs is common in all areas of medicine, but is specifically
      prevalent in pediatrics, oncology and in treating rare diseases. Such use may
      benefit patients, but on the other hand, there is concern about the safety
      aspects of these treatments. Besides the legal, ethical and safety issues
      associated with off-label use, arises the issue of whether such prescribing
      should be reimbursed by public funds. According to Ministry of Health (MoH)
      guidelines, the committee in charge of updating the National List of Health
      Services (NLHS) did not discuss, from its inception and until its deliberations
      at the end of 2008, off-label indications. This policy was to protect the Israeli
      pharmaceutical registration mechanism, prevent registration bypass mechanisms and
      not grant use of public funds for reimbursing treatments for which there were
      insufficient evidence on safety and efficacy. The patients most affected by this 
      policy were the ones that could not benefit from a drug that was not in the NLHS 
      for their medical condition and had to pay for it out of pocket. Occasionally,
      health plans agreed to subsidize critically needed off-label treatments, although
      they did not receive public funding for off-label indications. In this article we
      review the problems associated with off-label prescribing, the reasons why the
      MoH changed its policy at the beginning of 2009 to permit, in very special
      circumstances, reimbursement of off-label treatment. We also provide a brief
      summary of off-label policies in a few western countries.
FAU - Hammerman, Ariel
AU  - Hammerman A
AD  - Department of Health Systems Management, Ben-Gurion University of the Negev, Beer
      Sheba. arielha@clalit.org.il
FAU - Lipschitz, Yoel
AU  - Lipschitz Y
FAU - Pliskin, Joseph
AU  - Pliskin J
FAU - Greenberg, Dan
AU  - Greenberg D
LA  - heb
PT  - English Abstract
PT  - Journal Article
PL  - Israel
TA  - Harefuah
JT  - Harefuah
JID - 0034351
RN  - 0 (Prescription Drugs)
SB  - IM
MH  - Guidelines as Topic
MH  - Humans
MH  - Insurance, Health, Reimbursement/*economics
MH  - Insurance, Pharmaceutical Services/economics
MH  - Israel
MH  - National Health Programs/economics
MH  - Off-Label Use/*economics
MH  - Prescription Drugs/adverse effects/economics/therapeutic use
MH  - Reimbursement Mechanisms/*economics
EDAT- 2011/12/15 06:00
MHDA- 2011/12/23 06:00
CRDT- 2011/12/15 06:00
PHST- 2011/12/15 06:00 [entrez]
PHST- 2011/12/15 06:00 [pubmed]
PHST- 2011/12/23 06:00 [medline]
PST - ppublish
SO  - Harefuah. 2011 Feb;150(2):163-7, 204.


PMID- 22164936
OWN - NLM
STAT- MEDLINE
DCOM- 20111222
LR  - 20111212
IS  - 0017-7768 (Print)
IS  - 0017-7768 (Linking)
VI  - 150
IP  - 2
DP  - 2011 Feb
TI  - [Second medical opinions].
PG  - 105-10, 207
AB  - Second opinion is a decision-support tool for ratification or modification of a
      suggested treatment, by another physician. Second opinion may have a critical
      influence on the diagnosis, treatment and prognosis. The patient can benefit from
      treatment optimization and avoid unnecessary risks. The physician can benefit
      from less exposure to legal claims, and healthcare organizations can benefit from
      increased treatment, quality assurance and costs saving from unnecessary surgery 
      and treatments. Nevertheless, injudicious use of this tool can provoke
      unnecessary medical costs. In recent years, many patients prefer to seek a second
      opinion on their disease and available treatments. Private and public insurance
      companies are trying to control surgery costs by urging and even demanding a
      second opinion before surgery. Although second opinions are common in medical
      practice, relatively little is known on this subject. Most of the studies
      reviewed in this article evaluated the clinical benefit of second opinions, the
      reasons patients seek a second opinion and the characteristics of these patients,
      as well as technological interventions to promote second opinions, and ethical or
      legal issues related to second opinions. Yet, there are opportunities for further
      studies about physicians attitudes and barriers towards second opinions, their
      effect on patient-physician communication and cost-effectiveness analyses of
      second opinions. Due to the relevance of second opinions for public heath, this
      review aims to summarize the current research on second opinions.
FAU - Vashitz, Geva
AU  - Vashitz G
AD  - Ben-Gurion University of the Negev.
FAU - Davidovitch, Nadav
AU  - Davidovitch N
FAU - Pliskin, Joseph S
AU  - Pliskin JS
LA  - heb
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Israel
TA  - Harefuah
JT  - Harefuah
JID - 0034351
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Cost-Benefit Analysis
MH  - Ethics, Medical
MH  - Humans
MH  - Physician-Patient Relations
MH  - *Quality of Health Care
MH  - *Referral and Consultation/economics/ethics/legislation & jurisprudence
EDAT- 2011/12/15 06:00
MHDA- 2011/12/23 06:00
CRDT- 2011/12/15 06:00
PHST- 2011/12/15 06:00 [entrez]
PHST- 2011/12/15 06:00 [pubmed]
PHST- 2011/12/23 06:00 [medline]
PST - ppublish
SO  - Harefuah. 2011 Feb;150(2):105-10, 207.


PMID- 22164925
OWN - NLM
STAT- MEDLINE
DCOM- 20111222
LR  - 20111212
IS  - 0017-7768 (Print)
IS  - 0017-7768 (Linking)
VI  - 150
IP  - 4
DP  - 2011 Apr
TI  - [Forced medical treatment: existent law and its limitations in a general
      hospital].
PG  - 397-400, 416
AB  - The conditions in which we can provide medical treatment without informed consent
      are detailed in the Israeli Law for Treating the Mentally Ill [1991), and the Law
      of Patient Rights (1996). Our clinicaL experience in a general hospital indicates
      that the law does not provide a satisfactory solution in cases where the patient 
      is actively resisting emergency treatment. This may be the case for patients
      suffering from dementia, personality disorders or substance abuse disorders. Not 
      infrequently, the physician finds himself perplexed in face of a genuine
      ethical/juridical dilemma, without being able to use the law efficiently or, at
      times, even implement it pragmatically. in this article, we review the array of
      laws by which Israeli physicians in general, and psychiatrists in particular,
      operate upon when deciding to treat a patient against his will in a general
      hospital. We describe and discuss a clinicaL case that raises fundamental
      questions concerning the existing law. We also discuss other complex cases, such 
      as anorexia, debating the possibility of coercing medical treatment on someone
      who is not mentally ill--psychotic according to Israeli juridical system.
      Finally, we raise a few ideas as to how the present condition can be improved.
FAU - Nitzan, Uri
AU  - Nitzan U
AD  - Shalvata Mental Health Care Center, Hod Hasharon, Israel. urini@clalit.org.il
FAU - Lev-Ran, Shaul
AU  - Lev-Ran S
FAU - Phenig, Shmuel
AU  - Phenig S
LA  - heb
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
PL  - Israel
TA  - Harefuah
JT  - Harefuah
JID - 0034351
SB  - IM
MH  - Adult
MH  - Female
MH  - Hospitals, General/legislation & jurisprudence/methods
MH  - Humans
MH  - Informed Consent/*legislation & jurisprudence
MH  - Israel
MH  - Mental Disorders/*therapy
MH  - Patient Rights/*legislation & jurisprudence
EDAT- 2011/12/15 06:00
MHDA- 2011/12/23 06:00
CRDT- 2011/12/15 06:00
PHST- 2011/12/15 06:00 [entrez]
PHST- 2011/12/15 06:00 [pubmed]
PHST- 2011/12/23 06:00 [medline]
PST - ppublish
SO  - Harefuah. 2011 Apr;150(4):397-400, 416.


PMID- 22164809
OWN - NLM
STAT- MEDLINE
DCOM- 20120103
LR  - 20131121
IS  - 1078-6791 (Print)
IS  - 1078-6791 (Linking)
VI  - 17
IP  - 3
DP  - 2011 May-Jun
TI  - Is there more to yoga than exercise?
PG  - 22-9
AB  - CONTEXT: Yoga is increasing in popularity, with an estimated 15 million
      practitioners in the United States, yet there is a dearth of empirical data
      addressing the holistic benefits of yoga. OBJECTIVE: To compare the physical and 
      mental benefits of an exercise-based yoga practice to that of a more
      comprehensive yoga practice (one with an ethical/spiritual component). DESIGN:
      Students with mild to moderate depression, anxiety, or stress and who agreed to
      participate were assigned to one of three groups: integrated yoga, yoga as
      exercise, control. PARTICIPANTS: A total of 81 undergraduate students 18 years
      and older at a university in the southeastern United States participated in the
      study. MAIN OUTCOME MEASURES: Depression, anxiety, stress, hope, and salivary
      cortisol. RESULTS: Over time, participants in both the integrated and exercise
      yoga groups experienced decreased depression and stress, an increased sense of
      hopefulness, and increased flexibility compared to the control group. However,
      only the integrated yoga group experienced decreased anxiety-related symptoms and
      decreased salivary cortisol from the beginning to the end of the study.
      CONCLUSIONS: Yoga, practiced in a more integrated form, ie, with an ethical and
      spiritual component, may provide additional benefits over yoga practiced as an
      exercise regimen.
FAU - Smith, J Andy
AU  - Smith JA
AD  - The University of Southern Mississippi, Hattiesburg, USA.
FAU - Greer, Tammy
AU  - Greer T
FAU - Sheets, Timothy
AU  - Sheets T
FAU - Watson, Sheree
AU  - Watson S
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Altern Ther Health Med
JT  - Alternative therapies in health and medicine
JID - 9502013
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adult
MH  - Anxiety/*prevention & control
MH  - Chi-Square Distribution
MH  - Depression/*prevention & control
MH  - Female
MH  - Health Status
MH  - Humans
MH  - Hydrocortisone/analysis
MH  - Male
MH  - *Quality of Life
MH  - Reference Values
MH  - *Self Concept
MH  - Southeastern United States
MH  - Students/*psychology
MH  - Treatment Outcome
MH  - Yoga/*psychology
MH  - Young Adult
EDAT- 2011/12/15 06:00
MHDA- 2012/01/04 06:00
CRDT- 2011/12/15 06:00
PHST- 2011/12/15 06:00 [entrez]
PHST- 2011/12/15 06:00 [pubmed]
PHST- 2012/01/04 06:00 [medline]
PST - ppublish
SO  - Altern Ther Health Med. 2011 May-Jun;17(3):22-9.


PMID- 22164703
OWN - NLM
STAT- MEDLINE
DCOM- 20111223
LR  - 20170214
IS  - 0963-6625 (Print)
IS  - 0963-6625 (Linking)
VI  - 20
IP  - 5
DP  - 2011 Sep
TI  - A case of conflicting norms? Mobilizing and accountability information in
      newspaper coverage of the autism-vaccine controversy.
PG  - 609-26
AB  - When reporting health risks, the news media are often criticized for omitting
      "mobilizing" information that allows readers to act on existing attitudes. Using 
      American and British newspaper coverage of the autism-vaccine controversy as a
      case study, this article takes a "behind the scenes" look at normative pressures 
      that may influence whether such information appears in coverage. In particular,
      can holding health officials accountable for their actions potentially "crowd
      out" mobilizing information? A content analysis suggests that mobilizing
      information (at least one of four examples) was present in only 16% of articles, 
      compared to 38% that mentioned accountability messages (at least one of two
      examples). US newspapers were significantly more likely to mention at least one
      mobilization example. Finally, although only 11% discussed both, articles were
      more likely to discuss certain mobilizing and accountability examples together.
      Implications for journalism ethics and vaccine risk communication are discussed.
FAU - Clarke, Christopher E
AU  - Clarke CE
AD  - Department of Communication at Cornell University, Ithaca, NY 14850, USA.
      cec54@cornell.edu
LA  - eng
PT  - Journal Article
PL  - England
TA  - Public Underst Sci
JT  - Public understanding of science (Bristol, England)
JID - 9306503
RN  - 0 (Vaccines)
MH  - Autistic Disorder/*chemically induced
MH  - Communication
MH  - Decision Making
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Information Dissemination/ethics/*methods
MH  - *Newspapers as Topic
MH  - Public Health
MH  - Risk Assessment
MH  - Social Responsibility
MH  - Vaccines/*adverse effects
EDAT- 2011/12/15 06:00
MHDA- 2011/12/24 06:00
CRDT- 2011/12/15 06:00
PHST- 2011/12/15 06:00 [entrez]
PHST- 2011/12/15 06:00 [pubmed]
PHST- 2011/12/24 06:00 [medline]
AID - 10.1177/0963662509359490 [doi]
PST - ppublish
SO  - Public Underst Sci. 2011 Sep;20(5):609-26. doi: 10.1177/0963662509359490.


PMID- 22164547
OWN - NLM
STAT- MEDLINE
DCOM- 20120110
LR  - 20211021
IS  - 0008-4263 (Print)
IS  - 0008-4263 (Linking)
VI  - 102
IP  - 6
DP  - 2011 Nov-Dec
TI  - Population and public health ethics in Canada: a snapshot of current national
      initiatives and future issues.
PG  - 410-3
AB  - To date, some work has been undertaken to define a code and stewardship framework
      for public health ethics. However, gaps in our understanding and application of
      ethics to the field of population and public health (PPH) remain. This paper
      presents the approach to building capacity for PPH ethics by three national-level
      organizations: the Canadian Institutes of Health Research-Institute of Population
      and Public Health, the National Collaborating Centre for Healthy Public Policy,
      and the Public Health Agency of Canada. By first looking at each of the
      organizations' respective activities and then across organizations, we synthesize
      our common approaches, highlight future directions and pose questions aimed at
      stimulating dialogue about the role of, and challenges confronting, the emerging 
      field of PPH ethics in Canada.
FAU - Viehbeck, Sarah M
AU  - Viehbeck SM
AD  - Canadian Institutes of Health Research - Institute of Population and Public
      Health, Ottawa, ON. Sarah.Viehbeck@uottawa.ca
FAU - Melnychuk, Ryan
AU  - Melnychuk R
FAU - McDougall, Christopher W
AU  - McDougall CW
FAU - Greenwood, Heather
AU  - Greenwood H
FAU - Edwards, Nancy C
AU  - Edwards NC
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Can J Public Health
JT  - Canadian journal of public health = Revue canadienne de sante publique
JID - 0372714
SB  - IM
MH  - Canada
MH  - Capacity Building
MH  - Disaster Planning/standards
MH  - Disease Outbreaks/ethics/prevention & control
MH  - *Health Policy
MH  - Health Promotion/ethics/standards
MH  - *Health Status Disparities
MH  - Humans
MH  - Population Surveillance
MH  - Public Health/*ethics
MH  - *Vulnerable Populations
PMC - PMC6973607
EDAT- 2011/12/15 06:00
MHDA- 2012/01/11 06:00
CRDT- 2011/12/15 06:00
PHST- 2011/12/15 06:00 [entrez]
PHST- 2011/12/15 06:00 [pubmed]
PHST- 2012/01/11 06:00 [medline]
PST - ppublish
SO  - Can J Public Health. 2011 Nov-Dec;102(6):410-3.


PMID- 22163375
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 0277-2248 (Print)
IS  - 0092-9867 (Linking)
VI  - 93
IP  - 5-6
DP  - 2011 May
TI  - The plausibility of a role for mercury in the etiology of autism: a cellular
      perspective.
PG  - 1251-1273
AB  - Autism is defined by a behavioral set of stereotypic and repetitious behavioral
      patterns in combination with social and communication deficits. There is emerging
      evidence supporting the hypothesis that autism may result from a combination of
      genetic susceptibility and exposure to environmental toxins at critical moments
      in development. Mercury (Hg) is recognized as a ubiquitous environmental
      neurotoxin and there is mounting evidence linking it to neurodevelopmental
      disorders, including autism. Of course, the evidence is not derived from
      experimental trials with humans but rather from methods focusing on biomarkers of
      Hg damage, measurements of Hg exposure, epidemiological data, and animal studies.
      For ethical reasons, controlled Hg exposure in humans will never be conducted.
      Therefore, to properly evaluate the Hg-autism etiological hypothesis, it is
      essential to first establish the biological plausibility of the hypothesis. This 
      review examines the plausibility of Hg as the primary etiological agent driving
      the cellular mechanisms by which Hg-induced neurotoxicity may result in the
      physiological attributes of autism. Key areas of focus include: (1) route and
      cellular mechanisms of Hg exposure in autism; (2) current research and examples
      of possible genetic variables that are linked to both Hg sensitivity and autism; 
      (3) the role Hg may play as an environmental toxin fueling the oxidative stress
      found in autism; (4) role of mitochondrial dysfunction; and (5) possible role of 
      Hg in abnormal neuroexcitory and excitotoxity that may play a role in the immune 
      dysregulation found in autism. Future research directions that would assist in
      addressing the gaps in our knowledge are proposed.
FAU - Garrecht, Matthew
AU  - Garrecht M
AD  - Swinburne Autism Bio-Research Initiative, Faculty of Life and Social Sciences,
      Swinburne University of Technology, Hawthorn, Victoria 3122, Australia.
FAU - Austin, David W
AU  - Austin DW
LA  - eng
PT  - Journal Article
DEP - 20110520
PL  - England
TA  - Toxicol Environ Chem
JT  - Toxicological and environmental chemistry
JID - 8109171
PMC - PMC3173748
EDAT- 2011/12/14 06:00
MHDA- 2011/12/14 06:01
CRDT- 2011/12/14 06:00
PHST- 2011/12/08 00:00 [received]
PHST- 2011/04/10 00:00 [accepted]
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2011/12/14 06:01 [medline]
AID - 10.1080/02772248.2011.580588 [doi]
PST - ppublish
SO  - Toxicol Environ Chem. 2011 May;93(5-6):1251-1273. doi:
      10.1080/02772248.2011.580588. Epub 2011 May 20.


PMID- 22162963
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220318
IS  - 1615-6609 (Print)
IS  - 1615-6609 (Linking)
VI  - 8
IP  - 1
DP  - 2011 Nov
TI  - Service robotics: do you know your new companion? Framing an interdisciplinary
      technology assessment.
PG  - 25-44
AB  - Service-Robotic-mainly defined as "non-industrial robotics"-is identified as the 
      next economical success story to be expected after robots have been ubiquitously 
      implemented into industrial production lines. Under the heading of
      service-robotic, we found a widespread area of applications reaching from
      robotics in agriculture and in the public transportation system to service robots
      applied in private homes. We propose for our interdisciplinary perspective of
      technology assessment to take the human user/worker as common focus. In some
      cases, the user/worker is the effective subject acting by means of and in
      cooperation with a service robot; in other cases, the user/worker might become a 
      pure object of the respective robotic system, for example, as a patient in a
      hospital. In this paper, we present a comprehensive interdisciplinary framework, 
      which allows us to scrutinize some of the most relevant applications of service
      robotics; we propose to combine technical, economical, legal,
      philosophical/ethical, and psychological perspectives in order to design a
      thorough and comprehensive expert-based technology assessment. This allows us to 
      understand the potentials as well as the limits and even the threats connected
      with the ongoing and the planned implementation of service robots into human
      lifeworld-particularly of those technical systems displaying increasing grades of
      autonomy.
FAU - Decker, Michael
AU  - Decker M
AD  - Karlsruhe Institute of Technology, Karlsruhe, Germany.
FAU - Dillmann, Rudiger
AU  - Dillmann R
FAU - Dreier, Thomas
AU  - Dreier T
FAU - Fischer, Martin
AU  - Fischer M
FAU - Gutmann, Mathias
AU  - Gutmann M
FAU - Ott, Ingrid
AU  - Ott I
FAU - Spiecker Genannt Dohmann, Indra
AU  - Spiecker Genannt Dohmann I
LA  - eng
PT  - Journal Article
DEP - 20111103
PL  - Germany
TA  - Poiesis Prax
JT  - Poiesis & praxis : international journal of ethics of science and technology
      assessment
JID - 101083157
PMC - PMC3218273
EDAT- 2011/12/14 06:00
MHDA- 2011/12/14 06:01
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2011/12/14 06:01 [medline]
AID - 10.1007/s10202-011-0098-6 [doi]
AID - 98 [pii]
PST - ppublish
SO  - Poiesis Prax. 2011 Nov;8(1):25-44. doi: 10.1007/s10202-011-0098-6. Epub 2011 Nov 
      3.


PMID- 22162962
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1615-6609 (Print)
IS  - 1615-6609 (Linking)
VI  - 8
IP  - 1
DP  - 2011 Nov
TI  - Privacy revisited? Old ideals, new realities, and their impact on biobank
      regimes.
PG  - 9-24
AB  - Biobanks, collecting human specimen, medical records, and lifestyle-related data,
      face the challenge of having contradictory missions: on the one hand serving the 
      collective welfare through easy access for medical research, on the other hand
      adhering to restrictive privacy expectations of people in order to maintain their
      willingness to participate in such research. In this article, ethical frameworks 
      stressing the societal value of low-privacy expectations in order to secure
      biomedical research are discussed. It will turn out that neither utilitarian nor 
      communitarian or classical libertarian ethics frameworks will help to serve both 
      goals. Instead, John Rawls' differentiation of the "right" and the "good" is
      presented in order to illustrate the possibility of "serving two masters":
      individual interests of privacy, and societal interests of scientific progress
      and intergenerational justice. In order to illustrate this counterbalancing
      concept with an example, the five-pillar concept of the German Ethics Council
      will be briefly discussed.
FAU - Bialobrzeski, Arndt
AU  - Bialobrzeski A
AD  - Faculty of Philosophy and Department of Theology, Systematic Theology II
      (Ethics), PRIVATE Gen Project, Friedrich Alexander-University Erlangen-Nuremberg,
      Kochstrasse 6, 91054 Erlangen, Germany.
FAU - Ried, Jens
AU  - Ried J
FAU - Dabrock, Peter
AU  - Dabrock P
LA  - eng
PT  - Journal Article
DEP - 20110628
PL  - Germany
TA  - Poiesis Prax
JT  - Poiesis & praxis : international journal of ethics of science and technology
      assessment
JID - 101083157
PMC - PMC3218287
EDAT- 2011/12/14 06:00
MHDA- 2011/12/14 06:01
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2011/12/14 06:01 [medline]
AID - 10.1007/s10202-011-0094-x [doi]
AID - 94 [pii]
PST - ppublish
SO  - Poiesis Prax. 2011 Nov;8(1):9-24. doi: 10.1007/s10202-011-0094-x. Epub 2011 Jun
      28.


PMID- 22162635
OWN - NLM
STAT- MEDLINE
DCOM- 20120413
LR  - 20211021
IS  - 1110-7251 (Electronic)
IS  - 1110-7243 (Linking)
VI  - 2011
DP  - 2011
TI  - Modeling neurological disorders by human induced pluripotent stem cells.
PG  - 350131
LID - 10.1155/2011/350131 [doi]
AB  - Studies of human brain development are critical as research on neurological
      disorders have been progressively advanced. However, understanding the process of
      neurogenesis through analysis of the early embryo is complicated and limited by a
      number of factors, including the complexity of the embryos, availability, and
      ethical constrains. The emerging of human embryonic stem cells (hESCs) and
      induced pluripotent stem cells (iPSCs) has shed light of a new approach to study 
      both early development and disease pathology. The cells behave as precursors of
      all embryonic lineages; thus, they allow tracing the history from the root to
      individual branches of the cell lineage tree. Systems for neural differentiation 
      of hESCs and iPSCs have provided an experimental model that can be used to
      augment in vitro studies of in vivo brain development. Interestingly, iPSCs
      derived from patients, containing donor genetic background, have offered a
      breakthrough approach to study human genetics of neurodegenerative diseases. This
      paper summarizes the recent reports of the development of iPSCs from patients who
      suffer from neurological diseases and evaluates the feasibility of iPSCs as a
      disease model. The benefits and obstacles of iPSC technology are highlighted in
      order to raising the cautions of misinterpretation prior to further clinical
      translations.
FAU - Kunkanjanawan, Tanut
AU  - Kunkanjanawan T
AD  - Embryo Technology and Stem Cell Research Center, School of Biotechnology,
      Suranaree University of Technology, 111 University Avenue, Nakhon Ratchasima
      30000, Thailand.
FAU - Noisa, Parinya
AU  - Noisa P
FAU - Parnpai, Rangsun
AU  - Parnpai R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20111124
PL  - United States
TA  - J Biomed Biotechnol
JT  - Journal of biomedicine & biotechnology
JID - 101135740
SB  - IM
MH  - Brain/embryology/physiopathology
MH  - Cell Differentiation
MH  - Embryonic Stem Cells/*cytology
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*cytology/*physiology
MH  - *Models, Neurological
MH  - Nervous System Diseases/*pathology/*physiopathology/therapy
PMC - PMC3227533
EDAT- 2011/12/14 06:00
MHDA- 2012/04/14 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/07/11 00:00 [received]
PHST- 2011/10/06 00:00 [accepted]
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/04/14 06:00 [medline]
AID - 10.1155/2011/350131 [doi]
PST - ppublish
SO  - J Biomed Biotechnol. 2011;2011:350131. doi: 10.1155/2011/350131. Epub 2011 Nov
      24.


PMID- 22162014
OWN - NLM
STAT- MEDLINE
DCOM- 20120516
LR  - 20120118
IS  - 1097-0258 (Electronic)
IS  - 0277-6715 (Linking)
VI  - 31
IP  - 3
DP  - 2012 Feb 10
TI  - Optimal dose-finding designs with correlated continuous and discrete responses.
PG  - 217-34
LID - 10.1002/sim.4388 [doi]
AB  - In dose-finding clinical studies, it is common that multiple endpoints are of
      interest. For instance, in phase I/II studies, efficacy and toxicity are often
      the primary endpoints, which are observed simultaneously and which need to be
      evaluated together. Motivated by this, we confine ourselves to bivariate
      responses and focus on the most analytically difficult case: a mixture of
      continuous and categorical responses. We adopt the bivariate probit dose-response
      model and quantify our goal by a utility function. We study locally optimal
      designs, two-stage optimal designs, and fully adaptive designs under different
      ethical and cost constraints in the experiments. We assess the performance of
      two-stage designs and fully adaptive designs via simulations. Our simulations
      suggest that the two-stage designs are as efficient as and may be more efficient 
      than the fully adaptive designs if there is a moderate sample size in the initial
      stage. In addition, two-stage designs are easier to construct and implement and
      thus can be a useful approach in practice.
CI  - Copyright (c) 2011 John Wiley & Sons, Ltd.
FAU - Fedorov, Valerii
AU  - Fedorov V
AD  - Research Statistics Unit, Biomedical Data Sciences, GlaxoSmithKline, PO Box 5089,
      Collegeville, PA 19426, USA.
FAU - Wu, Yuehui
AU  - Wu Y
FAU - Zhang, Rongmei
AU  - Zhang R
LA  - eng
PT  - Journal Article
DEP - 20111212
PL  - England
TA  - Stat Med
JT  - Statistics in medicine
JID - 8215016
SB  - IM
MH  - Biomedical Research/statistics & numerical data
MH  - Clinical Trials, Phase I as Topic/*statistics & numerical data
MH  - Clinical Trials, Phase II as Topic/*statistics & numerical data
MH  - Computer Simulation/statistics & numerical data
MH  - *Dose-Response Relationship, Drug
MH  - Female
MH  - Humans
MH  - Male
MH  - Models, Biological
MH  - Research Design/statistics & numerical data
EDAT- 2011/12/14 06:00
MHDA- 2012/05/17 06:00
CRDT- 2011/12/14 06:00
PHST- 2010/08/29 00:00 [received]
PHST- 2011/08/08 00:00 [accepted]
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/05/17 06:00 [medline]
AID - 10.1002/sim.4388 [doi]
PST - ppublish
SO  - Stat Med. 2012 Feb 10;31(3):217-34. doi: 10.1002/sim.4388. Epub 2011 Dec 12.


PMID- 22161820
OWN - NLM
STAT- MEDLINE
DCOM- 20120829
LR  - 20180802
IS  - 1424-3997 (Electronic)
IS  - 0036-7672 (Linking)
VI  - 141
DP  - 2011
TI  - Financial incentives to improve organ donation: what is the opinion of the Vaud
      French-speaking population?
PG  - w13312
LID - 10.4414/smw.2011.13312 [doi]
LID - 2011;141:w13312 [pii]
AB  - BACKGROUND: With the increase of the organ shortage, several authors assume that 
      financial incentives would improve organ donation rates and fill the unbalance
      between the demand and the organs available for transplant medicine. This line of
      argument has been criticised with people arguing that an exchange of money for
      organs would violate the legal and the ethical principle of gratuity, decrease
      voluntarism and increase the body parts commodification phenomena. PURPOSE:
      Switzerland is often highlighted as having under-average organ donation rates
      compared to other European countries. In this paper we investigate the opinions
      of the Vaud French-speaking population concerning direct, indirect and non
      financial incentives in order to assess their opinions and anticipate the further
      debate. METHODS: As part of a broad survey about the organ donation
      decision-making process, questions about incentives for both living and deceased 
      organ donation were addressed to Vaud inhabitants and physicians. RESULTS: The
      data collected showed that respondents were opposed to rewarding both living and 
      deceased organ donation. The analysis of positive answers showed that indirect
      and non financial incentives were the most likely choice to acknowledge the
      donor's act. People in critical financial situations preferred direct financial
      incentives. CONCLUSIONS: These results showed that altruism and gratuity were
      key-values in the organ donation and transplantation social perceptions of the
      respondents. Thus, we assume that introducing financial incentives could tarnish 
      the image of transplant medicine. Nevertheless, further studies are needed to
      evaluate if their introduction would improve the organ donation rates or decrease
      voluntarism.
FAU - Bosisio, Francesca
AU  - Bosisio F
AD  - Interdisciplinary Ethics Unit (Ethos), Health Psychology Research Centre
      (CerPSa), Quartier UNIL Sorge, Amphipole, Bureau 211, 1015 Lausanne, Switzerland.
      francesca.bosisio@unil.ch
FAU - Santiago, Marie
AU  - Santiago M
FAU - Benaroyo, Lazare
AU  - Benaroyo L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111209
PL  - Switzerland
TA  - Swiss Med Wkly
JT  - Swiss medical weekly
JID - 100970884
SB  - IM
MH  - Adult
MH  - Altruism
MH  - Child
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - *Motivation
MH  - Organ Transplantation/ethnology/*psychology
MH  - *Public Opinion
MH  - Reward
MH  - Social Perception
MH  - Surveys and Questionnaires
MH  - Switzerland
MH  - Tissue and Organ Procurement/*economics/statistics & numerical data
EDAT- 2011/12/14 06:00
MHDA- 2012/08/30 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/08/30 06:00 [medline]
AID - smw-13312 [pii]
AID - 10.4414/smw.2011.13312 [doi]
PST - epublish
SO  - Swiss Med Wkly. 2011 Dec 9;141:w13312. doi: 10.4414/smw.2011.13312. eCollection
      2011.


PMID- 22160812
OWN - NLM
STAT- MEDLINE
DCOM- 20131213
LR  - 20220818
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 2
DP  - 2013 Jun
TI  - Introducing survival ethics into engineering education and practice.
PG  - 599-623
LID - 10.1007/s11948-011-9332-9 [doi]
AB  - Given the possibilities of synthetic biology, weapons of mass destruction and
      global climate change, humans may achieve the capacity globally to alter life.
      This crisis calls for an ethics that furnishes effective motives to take global
      action necessary for survival. We propose a research program for understanding
      why ethical principles change across time and culture. We also propose
      provisional motives and methods for reaching global consensus on engineering
      field ethics. Current interdisciplinary research in ethics, psychology,
      neuroscience and evolutionary theory grounds these proposals. Experimental
      ethics, the application of scientific principles to ethical studies, provides a
      model for developing policies to advance solutions. A growing literature proposes
      evolutionary explanations for moral development. Connecting these approaches
      necessitates an experimental or scientific ethics that deliberately examines
      theories of morality for reliability. To illustrate how such an approach works,
      we cover three areas. The first section analyzes cross-cultural ethical systems
      in light of evolutionary theory. While such research is in its early stages, its 
      assumptions entail consequences for engineering education. The second section
      discusses Howard University and University of Puerto Rico/Mayaguez (UPRM) courses
      that bring ethicists together with scientists and engineers to unite ethical
      theory and practice. We include a syllabus for engineering and STEM (Science,
      Technology, Engineering and Mathematics) ethics courses and a checklist model for
      translating educational theory and practice into community action. The model is
      based on aviation, medicine and engineering practice. The third and concluding
      section illustrates Howard University and UPRM efforts to translate engineering
      educational theory into community action. Multidisciplinary teams of engineering 
      students and instructors take their expertise from the classroom to global
      communities to examine further the ethicality of prospective technologies and the
      decision-making processes that lead to them.
FAU - Verharen, C
AU  - Verharen C
AD  - Howard University, Washington, DC 20059, USA. cverharen@howard.edu
FAU - Tharakan, J
AU  - Tharakan J
FAU - Middendorf, G
AU  - Middendorf G
FAU - Castro-Sitiriche, M
AU  - Castro-Sitiriche M
FAU - Kadoda, G
AU  - Kadoda G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20111209
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Checklist
MH  - *Curriculum
MH  - Decision Making/ethics
MH  - *Engineering/education/ethics
MH  - Ethical Theory
MH  - Ethics, Professional/*education
MH  - Humans
MH  - Models, Educational
MH  - *Morals
MH  - Policy Making
MH  - *Survival
MH  - Universities
EDAT- 2011/12/14 06:00
MHDA- 2013/12/18 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/06/22 00:00 [received]
PHST- 2011/11/24 00:00 [accepted]
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
AID - 10.1007/s11948-011-9332-9 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Jun;19(2):599-623. doi: 10.1007/s11948-011-9332-9. Epub 2011
      Dec 9.


PMID- 22159961
OWN - NLM
STAT- MEDLINE
DCOM- 20130104
LR  - 20120420
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 5
DP  - 2012 May
TI  - Intervening in clinical research to prevent the onset of psychoses: conflicts and
      obligations.
PG  - 319-21
LID - 10.1136/medethics-2011-100008 [doi]
AB  - A prevailing issue in clinical research is the duty clinicians have to treat or
      prevent the progression of disease during a study that they are conducting. While
      all clinical researchers have a duty of care for the patients who participate in 
      clinical research, intervening at the onset or progression of disease may skew
      results and have a negative impact on the scientific validity of a study. Extreme
      examples of failures to intervene can be found in the Tuskegee syphilis study and
      in an attempt to determine if cervical smears were an accurate predictor of
      cancer, which was uncovered by the Cartwright Inquiry. However, the issue arises 
      in all research where delay in intervention can cause harm. A current study in
      Singapore is investigating the significance of an 'ultra-high risk' state that
      may constitute the prodromal phase of psychosis. This project called 'The
      Longitudinal Youth at Risk Study' is potentially contentious because it is
      recruiting young people who are identified as being 'at risk' of developing
      psychosis. In this paper, the decision to offer treatment to all participants as 
      well as a fast track for those who are assessed to have developed serious mental 
      illness into treatment is discussed. It is argued that this approach is ethically
      justified because of the duty of care that is owed to research participants, and 
      suggests that the principle of equipoise may be used to guide intervention
      decisions in other clinical research protocols.
FAU - Lysaght, Tamra
AU  - Lysaght T
AD  - Centre for Biomedical Ethics, National University of Singapore, Singapore 119228.
      tamra.lysaght@nuhs.edu.sg
FAU - Capps, Benjimen James
AU  - Capps BJ
FAU - Campbell, Alastair Vincent
AU  - Campbell AV
FAU - Subramaniam, Mythily
AU  - Subramaniam M
FAU - Chong, Siow-Ann
AU  - Chong SA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111208
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Adolescent
MH  - Biomedical Research
MH  - Clinical Trials as Topic/*ethics
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Mental Disorders/complications/*therapy
MH  - Neuropsychological Tests
MH  - Psychotic Disorders/etiology/*prevention & control
MH  - *Research Subjects
MH  - Risk Assessment
MH  - Risk Factors
MH  - Singapore
MH  - Therapeutic Equipoise
MH  - Young Adult
EDAT- 2011/12/14 06:00
MHDA- 2013/01/05 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2013/01/05 06:00 [medline]
AID - medethics-2011-100008 [pii]
AID - 10.1136/medethics-2011-100008 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 May;38(5):319-21. doi: 10.1136/medethics-2011-100008. Epub
      2011 Dec 8.


PMID- 22158501
OWN - NLM
STAT- MEDLINE
DCOM- 20120405
LR  - 20171213
IS  - 2038-2529 (Electronic)
IS  - 0300-8916 (Linking)
VI  - 97
IP  - 5
DP  - 2011 Sep-Oct
TI  - Pastoral care in hospitals: a literature review.
PG  - 666-71
LID - 10.1700/989.10729 [doi]
AB  - AIMS AND BACKGROUND: This literature review investigates the potential
      contribution of the pastoral care provided in hospitals by hospital chaplains, as
      part of an integrated view of patient care, particularly in institutions dealing 
      with severe disease. METHODS AND STUDY DESIGN: A search was conducted in the
      Medline database covering the last 10 years. RESULTS: Ninety-eight articles were 
      considered concerning the modern hospital chaplains' relationships and the
      principal procedures and practices associated with their roles, i.e., their
      relations with the scientific world, with other religious figures in the
      community, with other faiths and religious confessions, with other public health 
      professionals and operators, with colleagues in professional associations and
      training activities, and with the hospital organization as a whole, as well as
      their patient assessment activities and the spiritual-religious support they
      provide, also for the patients' families. CONCLUSIONS: Improvements are needed on
      several fronts to professionalize the pastoral care provided in hospitals and
      modernize the figure of the hospital chaplain. These improvements include better 
      relations between modern chaplains and the hospital organization and scientific
      world; more focus on a scientific approach to their activities and on evaluating 
      the efficacy of pastoral care activities; greater clarity in the definition of
      the goals, methods and procedures; the design of protocols and a stance on
      important ethical issues; respect for the various faiths, different cultures and 
      both religious and nonreligious or secularized customs; greater involvement in
      the multidisciplinary patient care teams, of which the hospital chaplains are an 
      integral part; stronger integration with public health operators and cooperation 
      with the psychosocial professions; specific training on pastoral care and
      professional certification of chaplains; and the development of shared ethical
      codes for the profession.
FAU - Proserpio, Tullio
AU  - Proserpio T
AD  - Pastoral Care Unit, IRCCS Foundation National Cancer Institute of Milan, Italy.
      tullio.proserpio@istitutotumori.mi.it
FAU - Piccinelli, Claudia
AU  - Piccinelli C
FAU - Clerici, Carlo Alfredo
AU  - Clerici CA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Tumori
JT  - Tumori
JID - 0111356
SB  - IM
MH  - *Chaplaincy Service, Hospital/organization & administration/trends
MH  - Humans
MH  - Neoplasms/psychology/therapy
MH  - *Pastoral Care/methods/trends
MH  - *Patient Care Team/organization & administration/trends
MH  - *Religion and Medicine
MH  - *Spirituality
MH  - United Kingdom
MH  - United States
EDAT- 2011/12/14 06:00
MHDA- 2012/04/06 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/04/06 06:00 [medline]
AID - 10.1700/989.10729 [doi]
PST - ppublish
SO  - Tumori. 2011 Sep-Oct;97(5):666-71. doi: 10.1700/989.10729.


PMID- 22158148
OWN - NLM
STAT- MEDLINE
DCOM- 20120501
LR  - 20111213
IS  - 1476-5373 (Electronic)
IS  - 0007-0610 (Linking)
VI  - 211
IP  - 11
DP  - 2011 Dec 9
TI  - The ethics of cosmetics.
PG  - 501
LID - 10.1038/sj.bdj.2011.1004 [doi]
FAU - Hancocks, Stephen
AU  - Hancocks S
LA  - eng
PT  - Editorial
DEP - 20111209
PL  - England
TA  - Br Dent J
JT  - British dental journal
JID - 7513219
SB  - IM
MH  - Cosmetic Techniques/ethics
MH  - *Esthetics, Dental
MH  - *Ethics, Dental
MH  - Humans
EDAT- 2011/12/14 06:00
MHDA- 2012/05/02 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/05/02 06:00 [medline]
AID - sj.bdj.2011.1004 [pii]
AID - 10.1038/sj.bdj.2011.1004 [doi]
PST - epublish
SO  - Br Dent J. 2011 Dec 9;211(11):501. doi: 10.1038/sj.bdj.2011.1004.


PMID- 22158086
OWN - NLM
STAT- MEDLINE
DCOM- 20120518
LR  - 20190221
IS  - 1460-2350 (Electronic)
IS  - 0268-1161 (Linking)
VI  - 27
IP  - 2
DP  - 2012 Feb
TI  - Combined transanal and laparoscopic approach for the treatment of deep
      endometriosis infiltrating the rectum.
PG  - 418-26
LID - 10.1093/humrep/der422 [doi]
AB  - BACKGROUND: Two surgical approaches are employed in the treatment of deep
      infiltrating endometriosis of the rectum (DIER): colorectal resection and nodule 
      excision. In 2009, we introduced a new technique for transanal full thickness
      disc excision of endometriotic nodules infiltrating the low and middle rectum,
      using the Contour(R) Transtar stapler (Ethicon Endo-Surgery inc., Cincinnati, OH,
      USA). The aim of this retrospective study was to describe the technique and to
      present data on the feasibility of this technique. METHODS: From April 2009 to
      October 2010, all patients presenting with DIER and undergoing full thickness
      excision using the Contour(R) Transtar stapler were enrolled in the study. Pre-, 
      intra- and post-operative data were collected and reported. RESULTS: Six
      nulliparous women were managed using this technique during the study period. The 
      rectal wall discs removed measured from 40 x 45 to 60 x 50 mm. In two cases,
      microscopic foci were noted on one of the margins but in four cases the limits
      were clear. Operating time varied from 180 to 450 min. Four women were completely
      free of post-operative digestive complaints. CONCLUSIONS: Despite the small
      numbers in this series, our data suggest that the new technique of transanal
      rectal disc excision using the contour stapler may be applied in patients with
      infiltrating endometrial nodules of the rectum up to 10 cm from the anal margin
      and up to 5 cm in diameter. This new procedure promises to be a useful addition
      to the surgeon's armamentarium in a multidisciplinary approach to deep pelvic
      endometriosis.
FAU - Bridoux, Valerie
AU  - Bridoux V
AD  - Department of Digestive Surgery, Rouen University Hospital, Rouen, France.
FAU - Roman, Horace
AU  - Roman H
FAU - Kianifard, Babak
AU  - Kianifard B
FAU - Vassilieff, Maud
AU  - Vassilieff M
FAU - Marpeau, Loic
AU  - Marpeau L
FAU - Michot, Francis
AU  - Michot F
FAU - Tuech, Jean-Jacques
AU  - Tuech JJ
LA  - eng
PT  - Journal Article
DEP - 20111208
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
SB  - IM
CIN - Hum Reprod. 2012 Jun;27(6):1878; author reply 1878-9. PMID: 22493026
MH  - Adult
MH  - Anorectal Malformations
MH  - Anus, Imperforate/prevention & control
MH  - Cohort Studies
MH  - Endometriosis/pathology/*surgery
MH  - Feasibility Studies
MH  - Female
MH  - France
MH  - Humans
MH  - Laparoscopy/adverse effects/instrumentation/*methods
MH  - Postoperative Complications/prevention & control
MH  - Proctoscopy/adverse effects/instrumentation/*methods
MH  - Prospective Studies
MH  - Rectal Diseases/pathology/*surgery
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Surgical Staplers
MH  - Surveys and Questionnaires
EDAT- 2011/12/14 06:00
MHDA- 2012/05/19 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/05/19 06:00 [medline]
AID - der422 [pii]
AID - 10.1093/humrep/der422 [doi]
PST - ppublish
SO  - Hum Reprod. 2012 Feb;27(2):418-26. doi: 10.1093/humrep/der422. Epub 2011 Dec 8.


PMID- 22157604
OWN - NLM
STAT- MEDLINE
DCOM- 20120531
LR  - 20111214
IS  - 1550-1841 (Electronic)
IS  - 0741-5206 (Linking)
VI  - 31
IP  - 4
DP  - 2011 Oct-Dec
TI  - A historical, clinical, and ethical overview of the emerging science of facial
      transplantation.
PG  - 151-7
LID - 10.1097/PSN.0b013e31822f6611 [doi]
AB  - In the past 5 years, a total of 16 facial transplantation surgeries have been
      performed in France, China, Spain, and the United States. Facial transplantation 
      has become a surgical option in clinical situations in which soft tissue and bone
      loss is accompanied by severe cosmetic, sensory, and functional deficiencies due 
      to disease, trauma, or congenital malformations. With the introduction of facial 
      tissue transplantation surgery came complex clinical, technological, and ethical 
      patient care issues. These complex issues included determining patient selection 
      criteria, refining donor tissue procurement techniques, predicting expected
      functional outcomes, appreciating the limitations of obtaining a fully informed
      consent for an innovative procedure, and deliberating the immunological response 
      and postoperative immunosuppressant requirements of the recipient. In addition,
      psychological implications for the patient, societal consequences, and ethical
      concerns have been discussed. The short-term results have been positive. Results 
      to date indicate that the clinical, technical, and immunological patient care
      issues in this emerging science appear to mirror those of other reconstructive
      and organ transplantation procedures. The long-term physical, emotional, and
      psychological effects on the recipient patient, as well as long-term consequences
      to the donor's family, are yet to be validated.
FAU - Evans, Linda A
AU  - Evans LA
AD  - Burn and Trauma Program, Brigham and Women's Hospital, Boston, MA, USA.
      lindaevans07@hotmail.com
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Plast Surg Nurs
JT  - Plastic surgical nursing : official journal of the American Society of Plastic
      and Reconstructive Surgical Nurses
JID - 8403490
MH  - *Facial Transplantation/ethics/history/methods
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
EDAT- 2011/12/14 06:00
MHDA- 2012/06/01 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/06/01 06:00 [medline]
AID - 10.1097/PSN.0b013e31822f6611 [doi]
AID - 00006527-201110000-00005 [pii]
PST - ppublish
SO  - Plast Surg Nurs. 2011 Oct-Dec;31(4):151-7. doi: 10.1097/PSN.0b013e31822f6611.


PMID- 22157203
OWN - NLM
STAT- MEDLINE
DCOM- 20120313
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 262
IP  - 2
DP  - 2012 Feb
TI  - Ileal Crohn disease: mural microvascularity quantified with contrast-enhanced US 
      correlates with disease activity.
PG  - 680-8
LID - 10.1148/radiol.11110440 [doi]
AB  - PURPOSE: To quantitatively assess microvascular activation in the thickened ileal
      walls of patients with Crohn disease (CD) by using contrast-enhanced
      ultrasonography (US) and evaluate its correlation with widely used indexes of CD 
      activity. MATERIALS AND METHODS: This prospective study was approved by the
      ethics committee, and written informed consent was obtained from all patients.
      The authors examined 54 consecutively enrolled patients (mean age, 35.29 years;
      age range, 18-69 years; 39 men, 15 women) with endoscopically confirmed CD of the
      terminal ileum. Ileal wall segments thicker than 3 mm were examined with
      low-mechanical-index contrast-enhanced US and a second-generation US contrast
      agent. The authors analyzed software-plotted time-enhancement intensity curves to
      determine the maximum peak intensity (MPI) and wash-in slope coefficient (beta)
      and evaluated their correlation with (a) the composite index of CD activity
      (CICDA), (b) the CD activity index (CDAI), and (c) the simplified endoscopic
      score for CD (SES-CD, evaluated in 37 patients) for the terminal ileum.
      Statistical analysis was performed with the Mann-Whitney test, Spearman rank
      test, and receiver operating characteristic (ROC) analysis. RESULTS: MPI and beta
      coefficients were significantly increased in the 36 patients with a CICDA
      indicative of active disease (P<.0001 for both), the 33 patients with a CDAI of
      at least 150 (P<.032 and P<.0074, respectively), and the 26 patients with an
      SES-CD of at least 1 (P<.0001 and P<.002, respectively). ROC analysis revealed
      accurate identification (compared with CICDA) of active CD with an MPI threshold 
      of 24 video intensity (VI) (sensitivity, 97%; specificity, 83%) and a beta
      coefficient of 4.5 VI/sec (sensitivity, 86%; specificity, 83%). CONCLUSION:
      Contrast-enhanced US of the ileal wall is a promising method for objective,
      reproducible assessment of disease activity in patients with ileal CD.
CI  - (c) RSNA, 2011
FAU - De Franco, Antonio
AU  - De Franco A
AD  - Department of Bioimaging and Radiologic Science, Radiodiagnostics-Echography
      Service, Complesso Integrato Columbus, Universita Cattolica del Sacro Cuore,
      Largo Francesco Vito 8, 00161 Rome, Italy. antonio.defranco3@tin.it
FAU - Di Veronica, Alessandra
AU  - Di Veronica A
FAU - Armuzzi, Alessandro
AU  - Armuzzi A
FAU - Roberto, Italia
AU  - Roberto I
FAU - Marzo, Manuela
AU  - Marzo M
FAU - De Pascalis, Barbara
AU  - De Pascalis B
FAU - De Vitis, Italo
AU  - De Vitis I
FAU - Papa, Alfredo
AU  - Papa A
FAU - Bock, Enrico
AU  - Bock E
FAU - Danza, Francesco M
AU  - Danza FM
FAU - Bonomo, Lorenzo
AU  - Bonomo L
FAU - Guidi, Luisa
AU  - Guidi L
LA  - eng
PT  - Journal Article
DEP - 20111212
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - 0 (Phospholipids)
RN  - 0 (contrast agent BR1)
RN  - WS7LR3I1D6 (Sulfur Hexafluoride)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Contrast Media
MH  - Crohn Disease/*diagnostic imaging
MH  - Female
MH  - Humans
MH  - Ileitis/*diagnostic imaging
MH  - Male
MH  - Microvessels/*diagnostic imaging
MH  - Middle Aged
MH  - *Phospholipids
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Statistics as Topic
MH  - *Sulfur Hexafluoride
MH  - Ultrasonography/*methods
MH  - Young Adult
EDAT- 2011/12/14 06:00
MHDA- 2012/03/14 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/03/14 06:00 [medline]
AID - radiol.11110440 [pii]
AID - 10.1148/radiol.11110440 [doi]
PST - ppublish
SO  - Radiology. 2012 Feb;262(2):680-8. doi: 10.1148/radiol.11110440. Epub 2011 Dec 12.


PMID- 22157201
OWN - NLM
STAT- MEDLINE
DCOM- 20120313
LR  - 20220419
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 262
IP  - 2
DP  - 2012 Feb
TI  - Recurrent hepatocellular carcinoma treated with sequential transcatheter arterial
      chemoembolization and RF ablation versus RF ablation alone: a prospective
      randomized trial.
PG  - 689-700
LID - 10.1148/radiol.11110637 [doi]
AB  - PURPOSE: To compare prospectively the effects of radiofrequency (RF) ablation
      after transcatheter arterial chemoembolization (TACE) with those of RF ablation
      alone in the treatment of recurrent hepatocellular carcinoma (HCC). MATERIALS AND
      METHODS: This study was approved by the institutional ethics committee, and all
      patients gave written informed consent. From January 2002 to December 2006, 139
      patients with recurrent HCC measuring 5 cm in diameter or smaller were randomized
      to receive either sequential TACE and RF ablation (sequential treatment group,
      n=69) or RF ablation alone (RF ablation group, n=70). The survival curves were
      constructed with the Kaplan-Meier method and compared by using the log-rank test.
      Bonferroni correction was applied when multiple comparisons were performed.
      P<.0083 (.05/6) was considered indicative of a statistically significant
      difference. RESULTS: The 1-, 3-, and 5-year overall survival rates were 94%, 69%,
      and 46%, respectively, for the sequential treatment group and 82%, 47%, and 36%
      for the RF ablation group (P=.037). The corresponding recurrence-free survival
      rates were 80%, 45%, and 40% for the sequential treatment group and 64%, 18%, and
      18% for the ablation group (P=.005). At subgroup analyses, the overall survival
      for the sequential treatment group was better than that for the RF ablation group
      for patients with tumor recurrence 1 year or less after initial treatment
      (P=.004) and those with tumors measuring 3.1-5.0 cm (P=.002) but not for those
      with tumor recurrence more than 1 year after initial treatment (P=.421) and those
      with tumors 3.0 cm or smaller (P=.478). The recurrence-free survival in the
      sequential treatment group was better than that in the RF ablation group for
      patients with tumors measuring 3.1-5.0 cm (P<.001) but not for those with tumors 
      3.0 cm or smaller (P=.204). For recurrence-free survival, there was no
      significant difference between the two groups for patients with tumor recurrence 
      1 year or less or more than 1 year after initial treatment (P=.020 and P=.111,
      respectively). Logistic regression analysis showed that treatment allocation and 
      the interval between initial treatment and tumor recurrence were significant
      prognostic factors for overall survival, whereas the interval between initial
      treatment and tumor recurrence, treatment allocation, and tumor size were
      significant prognostic factors for recurrence-free survival. CONCLUSION: The
      efficacy of sequential TACE-RF ablation is better than that of RF ablation alone 
      for recurrent HCC.
CI  - (c) RSNA, 2011
FAU - Peng, Zhen-Wei
AU  - Peng ZW
AD  - Department of Hepatobiliary Surgery, Cancer Centre of Sun Yat-sen University, and
      The Second Affiliated Hospital of Guangzhou Medical College, 651 Dongfeng Rd
      East, Guangzhou 510060, China.
FAU - Zhang, Yao-Jun
AU  - Zhang YJ
FAU - Liang, Hui-Hong
AU  - Liang HH
FAU - Lin, Xiao-Jun
AU  - Lin XJ
FAU - Guo, Rong-Ping
AU  - Guo RP
FAU - Chen, Min-Shan
AU  - Chen MS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20111212
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Carcinoma, Hepatocellular/mortality/*therapy
MH  - Catheter Ablation/*statistics & numerical data
MH  - Chemoembolization, Therapeutic/*statistics & numerical data
MH  - China/epidemiology
MH  - Combined Modality Therapy
MH  - Female
MH  - Humans
MH  - Liver Neoplasms/mortality/*therapy
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/*mortality/*therapy
MH  - Prevalence
MH  - Risk Assessment
MH  - Risk Factors
MH  - Survival Analysis
MH  - Survival Rate
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2011/12/14 06:00
MHDA- 2012/03/14 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/03/14 06:00 [medline]
AID - radiol.11110637 [pii]
AID - 10.1148/radiol.11110637 [doi]
PST - ppublish
SO  - Radiology. 2012 Feb;262(2):689-700. doi: 10.1148/radiol.11110637. Epub 2011 Dec
      12.


PMID- 22156991
OWN - NLM
STAT- MEDLINE
DCOM- 20120313
LR  - 20211021
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 262
IP  - 2
DP  - 2012 Feb
TI  - Dose-dependent artifact in the far wall of the carotid artery at dynamic
      contrast-enhanced US.
PG  - 672-9
LID - 10.1148/radiol.11110968 [doi]
AB  - PURPOSE: To quantify a pseudoenhancement phenomenon observed during dynamic
      contrast material-enhanced ultrasonography (US) of the carotid artery, both in
      vitro and in vivo. MATERIALS AND METHODS: Ethical approval was obtained prior to 
      commencing this prospective case series, and each patient gave written informed
      consent. Thirty-one patients with 50%-99% internal carotid artery stenosis
      underwent dynamic contrast-enhanced US of the carotid bifurcation with use of 2
      mL of microbubbles. In the final 10 patients, an additional 1 mL bolus was
      administered after 15 minutes. Raw linear digital imaging and communications in
      medicine data were analyzed offline. Regions of interest were drawn within the
      common carotid artery lumen and immediately adjacent to the lumen in the near and
      far wall adventitia. Peak intensity was measured. An in vitro experiment with a
      single-channel flow phantom was also performed. This apparatus consisted of an
      8-mm-diameter latex tube placed in a tissue-mimicking fluid. Microbubble
      concentrations of 0.02%, 0.1%, 0.5%, 1%, and 2% were pumped into the tube.
      Regions of interest were drawn in a similar fashion to the in vivo experiments,
      and peak intensity was measured. The Wilcoxon signed rank and paired t tests were
      used to compare the difference between the near and far wall signal intensities
      at each dose; a multiplication factor comparing near and far wall signal
      intensity was derived. RESULTS: The far wall of the common carotid artery was
      significantly more echogenic than the near wall at 2 mL contrast agent doses
      (P<.0001, n=31), and the far wall signal intensity increased synchronously with
      that of the lumen. The difference in signal intensity between near and far wall
      regions was significantly greater at 2 mL than at 1 mL (P=.012, n=10). In vitro, 
      the phantom tubing demonstrated a similar pattern and magnitude of enhancement to
      that seen in vivo. CONCLUSION: A dose-dependent, nonlinear propagation artifact
      known as pseudoenhancement occurs in the far wall adventitia of the carotid
      artery and should not be mistaken as a marker of plaque vulnerability.
CI  - (c) RSNA, 2011
FAU - Thapar, Ankur
AU  - Thapar A
AD  - Academic Section of Vascular Surgery and Department of Experimental Medicine,
      Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0HS,
      England. a.thapar09@imperial.ac.uk
FAU - Shalhoub, Joseph
AU  - Shalhoub J
FAU - Averkiou, Michalakis
AU  - Averkiou M
FAU - Mannaris, Christophoros
AU  - Mannaris C
FAU - Davies, Alun H
AU  - Davies AH
FAU - Leen, Edward L S
AU  - Leen EL
LA  - eng
GR  - RCS/DMT 3RD ROUND (3)/DMT_/The Dunhill Medical Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111209
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - 0 (Phospholipids)
RN  - 0 (contrast agent BR1)
RN  - WS7LR3I1D6 (Sulfur Hexafluoride)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Artifacts
MH  - Carotid Arteries/diagnostic imaging/drug effects
MH  - Carotid Stenosis/*diagnostic imaging
MH  - Contrast Media/*administration & dosage
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Humans
MH  - Male
MH  - Phospholipids/*administration & dosage
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Sulfur Hexafluoride/*administration & dosage
MH  - Ultrasonography/*methods
EDAT- 2011/12/14 06:00
MHDA- 2012/03/14 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/03/14 06:00 [medline]
AID - radiol.11110968 [pii]
AID - 10.1148/radiol.11110968 [doi]
PST - ppublish
SO  - Radiology. 2012 Feb;262(2):672-9. doi: 10.1148/radiol.11110968. Epub 2011 Dec 9.


PMID- 22156941
OWN - NLM
STAT- MEDLINE
DCOM- 20120510
LR  - 20120202
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 19
IP  - 1
DP  - 2012 Jan
TI  - An integrated ethical decision-making model for nurses.
PG  - 139-59
LID - 10.1177/0969733011413491 [doi]
AB  - The study reviewed 20 currently-available structured ethical decision-making
      models and developed an integrated model consisting of six steps with useful
      questions and tools that help better performance each step: (1) the
      identification of an ethical problem; (2) the collection of additional
      information to identify the problem and develop solutions; (3) the development of
      alternatives for analysis and comparison; (4) the selection of the best
      alternatives and justification; (5) the development of diverse, practical ways to
      implement ethical decisions and actions; and (6) the evaluation of effects and
      development of strategies to prevent a similar occurrence. From a pilot-test of
      the model, nursing students reported positive experiences, including being
      satisfied with having access to a comprehensive review process of the ethical
      aspects of decision making and becoming more confident in their decisions. There 
      is a need for the model to be further tested and refined in both the educational 
      and practical environments.
FAU - Park, Eun-Jun
AU  - Park EJ
AD  - Department of Nursing, Kyungwon University, San 65 Bokjeong-Dong, Gyeonggi-Do,
      Korea. eunjunp@gmail.com
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111207
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Attitude of Health Personnel
MH  - *Decision Support Techniques
MH  - *Ethics, Nursing
MH  - Humans
MH  - *Models, Nursing
MH  - Nursing Evaluation Research
MH  - Pilot Projects
MH  - Students, Nursing/psychology
EDAT- 2011/12/14 06:00
MHDA- 2012/05/11 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/05/11 06:00 [medline]
AID - 0969733011413491 [pii]
AID - 10.1177/0969733011413491 [doi]
PST - ppublish
SO  - Nurs Ethics. 2012 Jan;19(1):139-59. doi: 10.1177/0969733011413491. Epub 2011 Dec 
      7.


PMID- 22156300
OWN - NLM
STAT- MEDLINE
DCOM- 20120301
LR  - 20161125
IS  - 0025-8172 (Print)
IS  - 0025-8172 (Linking)
VI  - 79
IP  - Pt 4
DP  - 2011
TI  - An international view of surgically assisted conception and surrogacy tourism.
PG  - 135-45
LID - 10.1258/mlj.2011.011029 [doi]
AB  - Modern medicine, specifically assisted reproductive technology (ART), has
      overtaken the law in many jurisdictions around the world. New technologies and
      practices open a Pandora's Box of ethical, religious, social and legal questions,
      and may present a variety of significant legal problems to the courts and
      legislators. Surrogate motherhood and pregnancy through ART have both attracted
      controversy. Some groups condemn ART and want it banned while its supporters
      acknowledge there is a need for legislative guidelines and regulations. A
      proposed statute, the Assisted Reproductive Technique Services Act, aimed at
      regulating reproductive technologies, including surrogacy arrangements, will be
      introduced in the Malaysian parliament, probably in 2012, and the Assisted
      Reproductive Technology (Regulation) Bill 2010 is already before the Indian
      parliament. This paper will discuss several of the potential socio-legal issues
      surrounding ART in the light of the complex situation, with a comparative
      analysis of the Malaysian, USA, UK and Indian positions.
FAU - Ahmad, Nehaluddin
AU  - Ahmad N
AD  - Sultan Sharif Ali Islamic University Brunei Darussalam, Adjunct Associate
      Professor, Law, Multimedia University, Malaysia.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Med Leg J
JT  - The Medico-legal journal
JID - 0412004
SB  - IM
MH  - Female
MH  - Humans
MH  - India
MH  - Malaysia
MH  - *Medical Tourism
MH  - Pregnancy
MH  - Reproductive Techniques, Assisted/ethics/*legislation & jurisprudence
MH  - Surrogate Mothers/*legislation & jurisprudence
MH  - United Kingdom
MH  - United States
EDAT- 2011/12/14 06:00
MHDA- 2012/03/02 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/03/02 06:00 [medline]
AID - 79/4/135 [pii]
AID - 10.1258/mlj.2011.011029 [doi]
PST - ppublish
SO  - Med Leg J. 2011;79(Pt 4):135-45. doi: 10.1258/mlj.2011.011029.


PMID- 22155873
OWN - NLM
STAT- MEDLINE
DCOM- 20120501
LR  - 20141120
IS  - 1576-8260 (Electronic)
IS  - 0004-0614 (Linking)
VI  - 64
IP  - 9
DP  - 2011 Nov
TI  - Minimally invasive training in urologic oncology.
PG  - 865-8
AB  - Use of minimally invasive surgical (MIS) techniques continues to expand in the
      field of urologic oncology; however, proficiency in these techniques is subject
      to a learning curve. Current training paradigms have incorporated MIS, but in a
      non-standardized fashion. Residency work-hour restrictions and ethical concerns
      may influence efforts to deliver adequate training during a defined residency
      period. Post-residency fellowships or mini-courses may help urologists gain
      proficiency in these skills, but are time-consuming and may not provide adequate 
      exposure. Surgical simulation with dry labs and augmentation with virtual reality
      are important adjuncts to operative training for MIS. The urologic oncologist
      must be familiar with open and MIS techniques to effectively treat cancer in the 
      least morbid way possible and adapt to the ever-changing field of MIS with
      dynamic training paradigms.
FAU - Liu, Jen-Jane
AU  - Liu JJ
AD  - Department of Urology, Stanford University School of Medicine, Stanford, CA
      94305-5118, USA.
FAU - Gonzalgo, Mark L
AU  - Gonzalgo ML
LA  - eng
LA  - spa
PT  - Journal Article
PL  - Spain
TA  - Arch Esp Urol
JT  - Archivos espanoles de urologia
JID - 0064757
SB  - IM
MH  - Humans
MH  - Medical Oncology/*education
MH  - Minimally Invasive Surgical Procedures/*education
MH  - Urology/*education
EDAT- 2011/12/14 06:00
MHDA- 2012/05/02 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/05/02 06:00 [medline]
PST - ppublish
SO  - Arch Esp Urol. 2011 Nov;64(9):865-8.


PMID- 22155809
OWN - NLM
STAT- MEDLINE
DCOM- 20120509
LR  - 20111213
IS  - 1512-0112 (Print)
IS  - 1512-0112 (Linking)
IP  - 199
DP  - 2011 Oct
TI  - [Development of medical tourism in Georgia. Problems and prospectiv (review)].
PG  - 64-74
AB  - Medical tourism is the movement of patients through a global network of health
      services. Medical tourists seek affordable healthcare on a timely basis in a
      variety of destination nations. The expansion of global medical services has
      sparked immense economic growth in developing nations and has created a new
      market for advertising access to care. Beyond offering a unique untapped market
      of services, medical tourism has invited a host of liability, malpractice and
      ethical concerns. The explosion of off-shore "mini-surgical" vacations will
      surely incite global unification and increased access, quality and affordability 
      of care. Medical tourism is a dynamic subset of global health care that
      incorporates a variety of services, procedures and venues of care. Health
      insurance coverage, the impact on domestic and global markets, and the use of
      international standards of care will be examined in combination with quality,
      access and cost parameters. The global nature of medical tourism invites a
      variety of legal and ethical issues and calls for an organizational body to
      monitor this new phenomenon. Finally, the future implications of the
      globalization of health services and systems will be discussed.
FAU - Gerzmava, O
AU  - Gerzmava O
FAU - Lomtadze, L
AU  - Lomtadze L
FAU - Kitovani, D
AU  - Kitovani D
FAU - Kadjrishvili, M
AU  - Kadjrishvili M
LA  - rus
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Georgia (Republic)
TA  - Georgian Med News
JT  - Georgian medical news
JID - 101218222
SB  - IM
MH  - Delivery of Health Care/*economics/legislation & jurisprudence
MH  - Developing Countries/economics
MH  - Georgia (Republic)
MH  - Health Services Accessibility
MH  - Humans
MH  - Insurance, Health/economics/legislation & jurisprudence
MH  - Internationality
MH  - Malpractice/legislation & jurisprudence
MH  - *Medical Tourism/ethics/legislation & jurisprudence
EDAT- 2011/12/14 06:00
MHDA- 2012/05/10 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/05/10 06:00 [medline]
PST - ppublish
SO  - Georgian Med News. 2011 Oct;(199):64-74.


PMID- 22155448
OWN - NLM
STAT- MEDLINE
DCOM- 20120827
LR  - 20220408
IS  - 1873-1570 (Electronic)
IS  - 0300-9572 (Linking)
VI  - 83
IP  - 6
DP  - 2012 Jun
TI  - Comparison of different video laryngoscopes for emergency intubation in a
      standardized airway manikin with immobilized cervical spine by experienced
      anaesthetists. A randomized, controlled crossover trial.
PG  - 740-5
LID - 10.1016/j.resuscitation.2011.11.024 [doi]
AB  - BACKGROUND: The aim of the present study was to evaluate whether different video 
      laryngoscopes (VLs) facilitate endotracheal intubation (ETI) faster or more
      secure than conventional laryngoscopy in a manikin with immobilized cervical
      spine. METHODS: After local ethics board approval, a standard airway manikin with
      cervical spine immobilization by means of a standard stiff collar was placed on a
      trauma stretcher. We compared times until glottic view, ETI, cuff block and first
      ventilation were achieved, and verified the endotracheal tube position, when
      using Macintosh laryngoscope, Glidescope Ranger, Storz C-MAC, Ambu Pentax AWS,
      Airtraq, and McGrath Series5 VLs in randomized order. Wilcoxon signed-rank test
      and McNemar's test were used for statistical analysis; p<0.05 was considered as
      significant. RESULTS: Twenty-three anaesthetists (mean age 32.1+/-4.9 years, mean
      experience in anaesthesia of 6.9+/-4.8 years) routinely involved in the
      management of multitrauma patients participated. The primary study end point,
      time to first effective ventilation, was achieved fastest when using Macintosh
      laryngoscope (21.0+/-7.6s) and was significantly slower with all other devices
      (Airtraq 33.2+/-23.9 s, p=0.002; Pentax AirwayScope 32.4+/-14.9 s, p=0.001; Storz
      C-MAC 34.1+/-23.9 s, p<0.001; McGrath Series5 101.7+/-108.3 s, p<0.001;
      Glidescope Ranger 46.3+/-59.1 s, p=0.001). Overall success rates were highest
      when using Macintosh, Airtraq and Storz C-MAC devices (100%), and were lower in
      Ambu Pentax AWS and Glidescope Ranger (87%, p=0.5) and in McGrath Series5 device 
      (72.2%, p=0.063). CONCLUSION: When used by experienced anaesthesiologists, video 
      laryngoscopes did not facilitate endotracheal intubation in this model with an
      immobilized cervical spine in a faster or more secure way than conventional
      laryngoscopy. However, data was gathered in a standardized model and further
      studies in real trauma patients are desirable to verify our findings.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Wetsch, Wolfgang A
AU  - Wetsch WA
AD  - Department of Anaesthesiology and Intensive Care Medicine, University Hospital of
      Cologne, Kerpener Str. 62, 50937 Cologne, Germany.
FAU - Spelten, Oliver
AU  - Spelten O
FAU - Hellmich, Martin
AU  - Hellmich M
FAU - Carlitscheck, Martin
AU  - Carlitscheck M
FAU - Padosch, Stephan A
AU  - Padosch SA
FAU - Lier, Heiko
AU  - Lier H
FAU - Bottiger, Bernd W
AU  - Bottiger BW
FAU - Hinkelbein, Jochen
AU  - Hinkelbein J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20111207
PL  - Ireland
TA  - Resuscitation
JT  - Resuscitation
JID - 0332173
SB  - IM
CIN - Resuscitation. 2012 Aug;83(8):e169; author reply e170-1. PMID: 22513350
MH  - Adult
MH  - *Anesthesia
MH  - *Cervical Vertebrae
MH  - *Clinical Competence
MH  - Cross-Over Studies
MH  - Emergencies
MH  - Female
MH  - Humans
MH  - *Immobilization
MH  - Intubation, Intratracheal/*instrumentation
MH  - *Laryngoscopes
MH  - Laryngoscopy
MH  - Male
MH  - Manikins
MH  - Video Recording
EDAT- 2011/12/14 06:00
MHDA- 2012/08/28 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/11/01 00:00 [received]
PHST- 2011/11/19 00:00 [revised]
PHST- 2011/11/28 00:00 [accepted]
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/08/28 06:00 [medline]
AID - S0300-9572(11)00678-2 [pii]
AID - 10.1016/j.resuscitation.2011.11.024 [doi]
PST - ppublish
SO  - Resuscitation. 2012 Jun;83(6):740-5. doi: 10.1016/j.resuscitation.2011.11.024.
      Epub 2011 Dec 7.


PMID- 22154952
OWN - NLM
STAT- MEDLINE
DCOM- 20130515
LR  - 20151119
IS  - 1532-2793 (Electronic)
IS  - 0260-6917 (Linking)
VI  - 33
IP  - 2
DP  - 2013 Feb
TI  - Nurse educators and professional ethics--ethical principles and their
      implementation from nurse educators' perspectives.
PG  - 133-7
LID - 10.1016/j.nedt.2011.11.013 [doi]
LID - S0260-6917(11)00314-5 [pii]
AB  - This study describes nurse educators' knowledge of the ethical principles of
      professional codes of ethics and educators' assessment of the implementation of
      principles of fairness and human respect. Data for this study was collected from 
      nurse educators in Finland. The data was analyzed by SPSS (15.0) for Windows. A
      total of 342 nurse educators participated. The response rate was 46%. Nurse
      educators knew well the ethical principles of professional codes governing their 
      work. Older and more experienced educators knew the principles better than
      younger and less experienced. According to the educators the principle of
      fairness was implemented the best whereas fair treatment of nurse educators and
      respect for educators' opinions in the society were implemented the weakest.
      Educators who knew the principles well assessed themselves to act in a fairer way
      and to respect other persons' opinions in a better way than educators who knew
      these principles less well. They also felt themselves to be better treated than
      educators having less knowledge of the principles. These findings can be utilized
      to develop nurse educators' ethics education. Further research should focus on
      students', colleagues' and superiors' assessments of nurse educators' ethical
      knowledge base to gain comparative data on the phenomenon.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Salminen, Leena
AU  - Salminen L
AD  - Department of Nursing Science, University of Turku, Lemminkaisenkatu 1, FI-20014 
      Turun yliopisto, Finland. leena.kaarina.salminen@utu.fi
FAU - Metsamaki, Riikka
AU  - Metsamaki R
FAU - Numminen, Olivia H
AU  - Numminen OH
FAU - Leino-Kilpi, Helena
AU  - Leino-Kilpi H
LA  - eng
PT  - Journal Article
DEP - 20111210
PL  - Scotland
TA  - Nurse Educ Today
JT  - Nurse education today
JID - 8511379
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Community-Institutional Relations
MH  - Education, Nursing/*organization & administration
MH  - *Ethics, Nursing
MH  - *Faculty, Nursing
MH  - Female
MH  - Finland
MH  - Humans
MH  - Interprofessional Relations/ethics
MH  - Male
MH  - Middle Aged
MH  - Nursing Education Research
MH  - Nursing Evaluation Research
MH  - Nursing Methodology Research
MH  - Surveys and Questionnaires
EDAT- 2011/12/14 06:00
MHDA- 2013/05/17 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/06/06 00:00 [received]
PHST- 2011/11/01 00:00 [revised]
PHST- 2011/11/17 00:00 [accepted]
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2013/05/17 06:00 [medline]
AID - S0260-6917(11)00314-5 [pii]
AID - 10.1016/j.nedt.2011.11.013 [doi]
PST - ppublish
SO  - Nurse Educ Today. 2013 Feb;33(2):133-7. doi: 10.1016/j.nedt.2011.11.013. Epub
      2011 Dec 10.


PMID- 22154924
OWN - NLM
STAT- MEDLINE
DCOM- 20120905
LR  - 20161209
IS  - 2213-0276 (Electronic)
IS  - 0755-4982 (Linking)
VI  - 41
IP  - 7-8
DP  - 2012 Jul
TI  - [The surrogate for inpatients].
PG  - 730-5
LID - 10.1016/j.lpm.2011.10.015 [doi]
AB  - The French legal framework of the surrogate has been defined by a law passed in
      2002 concerning the patients' rights, in response to the absence of prior rights 
      of the incompetent patient. The surrogate is designated only by a competent major
      patient. In the case of competent patient, the surrogate may support the patient 
      throughout the course of care, including during the hospitalizations or
      consultations. In the case of incompetent patient, the surrogate must be involved
      in the decision-making process. A poor designation and a lack of the surrogate's 
      involvement emerge from different French studies since 2002, especially in the
      end-of-life decisions, despite a specific law passed in 2005, which reinforced
      the surrogate's role in this context. The evolution of the patients' rights, in
      France as in most of the industrialized countries, should lead to specific
      actions to improve the surrogate's involvement, in the respect of the ethical
      principles of autonomy, beneficence and non-maleficence.
CI  - Copyright (c) 2011 Elsevier Masson SAS. All rights reserved.
FAU - Ferrand, Edouard
AU  - Ferrand E
AD  - Service d'anesthesie, Hopital Foch, 40 rue Worth, Suresnes, France.
      e.ferrand@hopital-foch.org
FAU - Pham, Tai
AU  - Pham T
LA  - fre
PT  - English Abstract
PT  - Historical Article
PT  - Journal Article
PT  - Review
TT  - Personne de confiance pour les patients hospitalises.
DEP - 20111209
PL  - France
TA  - Presse Med
JT  - Presse medicale (Paris, France : 1983)
JID - 8302490
SB  - IM
MH  - Beneficence
MH  - *Decision Making/ethics
MH  - Ethics, Medical
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - *Informed Consent/ethics/history
MH  - *Inpatients/psychology
MH  - Patient Rights/history
MH  - Personal Autonomy
EDAT- 2011/12/14 06:00
MHDA- 2012/09/06 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/08/12 00:00 [received]
PHST- 2011/09/28 00:00 [revised]
PHST- 2011/10/05 00:00 [accepted]
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/09/06 06:00 [medline]
AID - S0755-4982(11)00562-8 [pii]
AID - 10.1016/j.lpm.2011.10.015 [doi]
PST - ppublish
SO  - Presse Med. 2012 Jul;41(7-8):730-5. doi: 10.1016/j.lpm.2011.10.015. Epub 2011 Dec
      9.


PMID- 22154874
OWN - NLM
STAT- MEDLINE
DCOM- 20130523
LR  - 20130304
IS  - 1532-2793 (Electronic)
IS  - 0260-6917 (Linking)
VI  - 33
IP  - 3
DP  - 2013 Mar
TI  - A pilot project in distance education: nurse practitioner students' experience of
      personal video capture technology as an assessment method of clinical skills.
PG  - 253-7
LID - 10.1016/j.nedt.2011.11.014 [doi]
LID - S0260-6917(11)00315-7 [pii]
AB  - This paper reports on a pilot project aimed at exploring postgraduate distance
      students' experiences using personal video capture technology to complete
      competency assessments in physical examination. A pre-intervention survey
      gathered demographic data from nurse practitioner students (n=31) and measured
      their information communication technology fluency. Subsequently, thirteen (13)
      students were allocated a hand held video camera to use in their clinical
      setting. Those participating in the trial completed a post-intervention survey
      and further data were gathered using semi-structured interviews. Data were
      analysed by descriptive statistics and deductive content analysis, and the
      Unified Theory of Acceptance and Use of Technology (Venkatesh et al., 2003) were 
      used to guide the project. Uptake of the intervention was high (93%) as students 
      recognised the potential benefit. Students were video recorded while performing
      physical examinations. They described high level of stress and some anxiety,
      which decreased rapidly while assessment was underway. Barriers experienced were 
      in the areas of facilitating conditions (technical character e.g. upload of
      files) and social influence (e.g. local ethical approval). Students valued the
      opportunity to reflect on their recorded performance with their clinical mentors 
      and by themselves. This project highlights the demands and difficulties of
      introducing technology to support work-based learning.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Strand, Haakan
AU  - Strand H
AD  - The University of Queensland, School of Nursing and Midwifery, Brisbane,
      Australia. h.strand@uq.edu.au
FAU - Fox-Young, Stephanie
AU  - Fox-Young S
FAU - Long, Phil
AU  - Long P
FAU - Bogossian, Fiona
AU  - Bogossian F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111210
PL  - Scotland
TA  - Nurse Educ Today
JT  - Nurse education today
JID - 8511379
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - *Clinical Competence
MH  - Education, Distance/*organization & administration
MH  - Education, Nursing, Graduate
MH  - Educational Measurement/*methods
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nurse Practitioners/*education
MH  - Nursing Education Research
MH  - Nursing Evaluation Research
MH  - Nursing Methodology Research
MH  - Physical Examination/nursing
MH  - Pilot Projects
MH  - Qualitative Research
MH  - Students, Nursing/*psychology
MH  - *Videotape Recording
EDAT- 2011/12/14 06:00
MHDA- 2013/05/25 06:00
CRDT- 2011/12/14 06:00
PHST- 2010/12/21 00:00 [received]
PHST- 2011/11/04 00:00 [revised]
PHST- 2011/11/16 00:00 [accepted]
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2013/05/25 06:00 [medline]
AID - S0260-6917(11)00315-7 [pii]
AID - 10.1016/j.nedt.2011.11.014 [doi]
PST - ppublish
SO  - Nurse Educ Today. 2013 Mar;33(3):253-7. doi: 10.1016/j.nedt.2011.11.014. Epub
      2011 Dec 10.


PMID- 22152917
OWN - NLM
STAT- MEDLINE
DCOM- 20120507
LR  - 20111214
IS  - 1578-1747 (Electronic)
IS  - 0211-139X (Linking)
VI  - 46 Suppl 1
DP  - 2011 Oct
TI  - [Ethical considerations in the presymptomatic diagnosis of Alzheimer's disease].
PG  - 55-9
LID - 10.1016/j.regg.2011.10.011 [doi]
AB  - Research into the human genome has undoubtedly opened up a new perspective in
      medicine. The ability to identify the cause of specific diseases, especially
      neurodegenerative diseases, will definitively change the concepts of disease and 
      treatment, while advances such as antibiotic therapy and anesthesia will be
      relegated to history. However, the arrival of genome medicine poses major
      bioethical challenges, many of which remain to be resolved. We review the
      applicability, results and consequences of predictions based on genetic tests for
      presymptomatic Alzheimer's disease, as well as the dilemmas and contradictions
      that are already arising as a result of the commercialization of predictive tests
      for public use with little or no medical supervision. Given that there is
      currently no effective treatment of Alzheimers disease, the greatest challenge
      and contradiction lies in managing the results of predictive tests. There are no 
      indications for the performance of predictive genetic tests in late or sporadic
      Alzheimer's disease or for counselling of persons requesting these tests. The
      PICOGEN program provides a safe, effective, reliable and satisfactory option for 
      persons requesting these tests who meet the inclusion criteria. Currently,
      caution should be the norm when considering the performance of predictive tests
      in presymptomatic dementia.
CI  - Copyright (c) 2011 SEGG. Published by Elsevier Espana. All rights reserved.
FAU - Kessel Sardinas, Humberto
AU  - Kessel Sardinas H
AD  - Unidad de Valoracion y Cuidados Geriatricos, Hospital Torrecardenas, Almeria,
      Espana. humberto.kessel@gmail.com
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Aspectos eticos del diagnostico presintomatico de la enfermedad de Alzheimer.
PL  - Spain
TA  - Rev Esp Geriatr Gerontol
JT  - Revista espanola de geriatria y gerontologia
JID - 8009022
SB  - IM
MH  - Alzheimer Disease/*diagnosis
MH  - *Bioethical Issues
MH  - Disease Progression
MH  - Early Diagnosis
MH  - Humans
EDAT- 2011/12/14 06:00
MHDA- 2012/05/09 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/05/09 06:00 [medline]
AID - S0211-139X(11)00293-9 [pii]
AID - 10.1016/j.regg.2011.10.011 [doi]
PST - ppublish
SO  - Rev Esp Geriatr Gerontol. 2011 Oct;46 Suppl 1:55-9. doi:
      10.1016/j.regg.2011.10.011.


PMID- 22152541
OWN - NLM
STAT- MEDLINE
DCOM- 20120426
LR  - 20111213
IS  - 1467-1107 (Electronic)
IS  - 1047-9511 (Linking)
VI  - 21 Suppl 2
DP  - 2011 Dec
TI  - Foetal cardiac intervention: an ethical perspective.
PG  - 141-7
LID - 10.1017/S1047951111001727 [doi]
AB  - Although recent advances have helped identify cases where foetal cardiac surgery 
      might reverse the development of certain lesions, the indications and measurement
      of success in these procedures have yet to be established. Thus, both patients
      and physicians have a "burden of knowledge", whereby a diagnosis is made without 
      a clear course of action. The profound issues raised by foetal intervention,
      specifically the question of how concepts such as "patient" and "success" can be 
      used, complicate this burden further and test the limits of language and logic.
      Similar issues raised in postmodern philosophy are discussed and can be
      incorporated into foetal cardiac surgery dialogues to produce a
      multi-disciplinary approach that will elucidate, not obfuscate, these issues in
      the future.
FAU - Mavroudis, Constantine D
AU  - Mavroudis CD
AD  - Loyola University Chicago, Stritch School of Medicine, 1645 W Ogden Ave.,
      Chicago, IL 60612, USA. cdmavroudis@gmail.com
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Cardiol Young
JT  - Cardiology in the young
JID - 9200019
SB  - IM
MH  - *Cardiac Surgical Procedures
MH  - *Ethics, Medical
MH  - Female
MH  - Fetal Therapies/*ethics/methods
MH  - *Heart Defects, Congenital/diagnosis/embryology/surgery
MH  - Humans
MH  - Infant, Newborn
MH  - Pregnancy
MH  - Pregnancy Outcome
MH  - Prenatal Diagnosis
EDAT- 2011/12/14 06:00
MHDA- 2012/04/27 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/04/27 06:00 [medline]
AID - S1047951111001727 [pii]
AID - 10.1017/S1047951111001727 [doi]
PST - ppublish
SO  - Cardiol Young. 2011 Dec;21 Suppl 2:141-7. doi: 10.1017/S1047951111001727.


PMID- 22152540
OWN - NLM
STAT- MEDLINE
DCOM- 20120426
LR  - 20111213
IS  - 1467-1107 (Electronic)
IS  - 1047-9511 (Linking)
VI  - 21 Suppl 2
DP  - 2011 Dec
TI  - Informed consent, bioethical equipoise, and hypoplastic left heart syndrome.
PG  - 133-40
LID - 10.1017/S1047951111001715 [doi]
AB  - In utero diagnosis of complex progressive cardiac disease such as hypoplastic
      left heart syndrome presents a novel opportunity for antepartum, intrapartum, and
      neonatal management. The clinical possibilities and potential for differing
      outcomes challenge the mother-foetus dyad with regard to informed consent.
      Previous studies reveal that rates of termination of pregnancy for foetuses with 
      hypoplastic left heart syndrome vary widely in the United States and Europe,
      leading us to surmise that informed consent may be practised differently. The
      purpose of this paper is to review the ethical considerations and physician
      responsibilities of informed consent as they relate to prenatal and postnatal
      patients with hypoplastic left heart syndrome. Special consideration is paid to
      the informed consent process as practised by the obstetrician, perinatologist,
      paediatric cardiologist, and paediatric cardiac surgeon as it relates to
      termination of pregnancy, comfort care, and surgical palliation. We will argue
      that informed consent as it relates to hypoplastic left heart syndrome is far
      from standardised and that there exists a state of bioethical equipoise
      concerning the extent and limits of its application in the current clinical
      setting.
FAU - Mavroudis, Constantine
AU  - Mavroudis C
AD  - Department of Pediatric and Adult Congenital Heart Surgery, Center for Ethics,
      Humanities and Spiritual Care, Cleveland Clinic Children's Hospital, 9500Euclid
      Avenue/M41-02, Cleveland, Ohio 44195, USA. mavrouc@ccf.org
FAU - Mavroudis, Constantine D
AU  - Mavroudis CD
FAU - Farrell, Ruth M
AU  - Farrell RM
FAU - Jacobs, Marshall L
AU  - Jacobs ML
FAU - Jacobs, Jeffrey P
AU  - Jacobs JP
FAU - Kodish, Eric D
AU  - Kodish ED
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Cardiol Young
JT  - Cardiology in the young
JID - 9200019
SB  - IM
MH  - *Bioethical Issues
MH  - Cardiac Surgical Procedures
MH  - Delivery of Health Care/*ethics
MH  - Female
MH  - Humans
MH  - *Hypoplastic Left Heart Syndrome/diagnosis/psychology/surgery
MH  - Infant, Newborn
MH  - Informed Consent/*ethics
MH  - Pregnancy
MH  - Pregnancy Outcome
MH  - Prenatal Diagnosis/*ethics
EDAT- 2011/12/14 06:00
MHDA- 2012/04/27 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/04/27 06:00 [medline]
AID - S1047951111001715 [pii]
AID - 10.1017/S1047951111001715 [doi]
PST - ppublish
SO  - Cardiol Young. 2011 Dec;21 Suppl 2:133-40. doi: 10.1017/S1047951111001715.


PMID- 22152216
OWN - NLM
STAT- MEDLINE
DCOM- 20120326
LR  - 20211021
IS  - 1475-2891 (Electronic)
IS  - 1475-2891 (Linking)
VI  - 10
DP  - 2011 Dec 12
TI  - Lack of effect of high-protein vs. high-carbohydrate meal intake on
      stress-related mood and eating behavior.
PG  - 136
LID - 10.1186/1475-2891-10-136 [doi]
AB  - BACKGROUND: Consumption of meals with different macronutrients, especially high
      in carbohydrates, may influence stress-related eating behavior. We aimed to
      investigate whether consumption of high-protein vs. high-carbohydrate meals
      influences stress-related mood, food reward, i.e. 'liking' and 'wanting', and
      post-meal energy intake. METHODS: Participants (n = 38, 19m/19f, age = 25 +/- 9
      y, BMI = 25.0 +/- 3.3 kg/m2) came to the university four times, fasted, once for 
      a stress session receiving a high-protein meal, once for a rest session receiving
      a high-protein meal, once for a stress session receiving a high-carbohydrate meal
      and once for a rest session receiving a high-carbohydrate meal (randomized
      cross-over design). The high-protein and high-carbohydrate test meals (energy
      percentage protein/carbohydrate/fat 65/5/30 vs. 6/64/30) matched for energy
      density (4 kJ/g) and daily energy requirements (30%). Stress was induced using an
      ego-threatening test. Pre- and post-meal 'liking' and 'wanting' (for bread,
      filling, drinks, dessert, snacks, stationery (non-food alternative as control))
      was measured by means of a computer test. Following the post-meal 'wanting'
      measurement, participants received and consumed their wanted food items
      (post-meal energy intake). Appetite profile (visual analogue scales), mood state 
      (Profile Of Mood State and State Trait Anxiety Inventory questionnaires), and
      post-meal energy intake were measured. RESULTS: Participants showed increased
      feelings of depression and anxiety during stress (P < 0.01). Consumption of the
      test meal decreased hunger, increased satiety, decreased 'liking' of bread and
      filling, and increased 'liking' of placebo and drinks (P < 0.0001). Food
      'wanting' decreased pre- to post-meal (P < 0.0001). The high-protein vs.
      high-carbohydrate test meal induced lower subsequent 'wanting' and energy intake 
      (1.7 +/- 0.3 MJ vs. 2.5 +/- 0.4 MJ) only in individuals characterized by
      disinhibited eating behavior (factor 2 Three Factor Eating Questionnaire, n =
      16), during rest (P </= 0.01). This reduction in 'wanting' and energy intake
      following the high-protein meal disappeared during stress. CONCLUSIONS:
      Consumption of a high-protein vs. high-carbohydrate meal appears to have limited 
      impact on stress-related eating behavior. Only participants with high
      disinhibition showed decreased subsequent 'wanting' and energy intake during
      rest; this effect disappeared under stress. Acute stress overruled effects of
      consumption of high-protein foods. TRIAL REGISTRATION: The study was registered
      in the Dutch Trial Register (NTR1904). The protocol described here in this study 
      deviates from the trial protocol approved by the Medical Ethical Committee of the
      Maastricht University as it comprises only a part of the approved trial protocol.
FAU - Lemmens, Sofie G
AU  - Lemmens SG
AD  - Top Institute Food and Nutrition, Wageningen, The Netherlands.
      s.lemmens@maastrichtuniversity.nl
FAU - Martens, Eveline A
AU  - Martens EA
FAU - Born, Jurriaan M
AU  - Born JM
FAU - Martens, Mieke J
AU  - Martens MJ
FAU - Westerterp-Plantenga, Margriet S
AU  - Westerterp-Plantenga MS
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20111212
PL  - England
TA  - Nutr J
JT  - Nutrition journal
JID - 101152213
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Proteins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Affect/physiology
MH  - Anxiety
MH  - Appetite
MH  - Body Mass Index
MH  - Choice Behavior
MH  - Cross-Over Studies
MH  - Depression
MH  - Dietary Carbohydrates/*administration & dosage
MH  - Dietary Proteins/*administration & dosage
MH  - *Energy Intake
MH  - *Feeding Behavior
MH  - Female
MH  - Food Preferences
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Postprandial Period
MH  - Satiation
MH  - *Stress, Psychological
MH  - Surveys and Questionnaires
MH  - Young Adult
PMC - PMC3251533
EDAT- 2011/12/14 06:00
MHDA- 2012/03/27 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/05/11 00:00 [received]
PHST- 2011/12/12 00:00 [accepted]
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/03/27 06:00 [medline]
AID - 1475-2891-10-136 [pii]
AID - 10.1186/1475-2891-10-136 [doi]
PST - epublish
SO  - Nutr J. 2011 Dec 12;10:136. doi: 10.1186/1475-2891-10-136.


PMID- 22151887
OWN - NLM
STAT- MEDLINE
DCOM- 20120328
LR  - 20211021
IS  - 1477-7827 (Electronic)
IS  - 1477-7827 (Linking)
VI  - 9
DP  - 2011 Dec 12
TI  - Cryopreservation of human failed-matured oocytes followed by in vitro maturation:
      vitrification is superior to the slow freezing method.
PG  - 156
LID - 10.1186/1477-7827-9-156 [doi]
AB  - BACKGROUND: Oocyte cryopreservation is an important method used in a number of
      human fertility circumstances. Here, we compared the survival, in vitro
      maturation, fertilization, and early embryonic development rates of frozen-thawed
      human immature oocytes using two different cryopreservation methods. METHODS: A
      total of 454 failed-matured oocytes [germinal vesicle (GV) and metaphase I (MI)
      stages] were collected from 135 patients (mean age 33.84 +/- 5.0 y) who underwent
      intracytoplasmic sperm injection (ICSI) cycles between February 2009 and December
      2009 and randomly divided into a slow freezing group [1.5 mol/L-1, 2-propanediol 
      (PROH) + 0.2 mol/l sucrose] and vitrification group [20% PROH + 20% ethylene
      glycol (EG) + 0.5 mol/l sucrose]. RESULTS: The vitrification protocol yielded a
      better survival rate than the slow freezing protocol at each maturation stage
      assessed. Regardless of the maturation stage (GV + MI), the slow freezing
      protocol had a significantly lower survival rate than the vitrification protocol 
      (p < 0.001). In addition, a significant difference was found in the survival
      rates between GV and MI oocytes regardless of the protocol used (90.1 vs. 64.7%, 
      respectively; p < 0.01). We also found that the maturation rates of GV and MI
      oocytes from the slow freezing and vitrification groups were 16.7 vs. 24.4% and
      50.8 vs. 55.4%, respectively. Regardless of the protocol used, the GV oocytes had
      significantly lower viability than MI oocytes after 36 h of in vitro maturation
      (21.2 vs. 54.0%, respectively; p < 0.01). In addition, the GV and MI oocytes from
      the slow freezing group had a markedly lower maturation rate than those from the 
      vitrification group (33.6 vs. 43.1%, respectively), but no statistical difference
      was found between the two groups (P > 0.05). For the GV-matured oocytes, no
      fertilized eggs were obtained in the slow-freezing group, while a 19.0% (4/21)
      fertilization rate was observed in the vitrification group. For the MI-matured
      oocytes, fertilization rates for the slow freezing and vitrified groups were 36% 
      and 61.1%, respectively, but no significant difference was found between the two 
      groups (PIn the Methods section in the MS, all procedures were compliant with
      ethical guidelines, i.e. approved by the Ethical Committee of our university and 
      Informed Consent signed by each patient. > 0.05). In the GV vitrification group, 
      no embryo formed; however, in the MI slow freezing group, 12 oocytes were
      fertilized, but only two achieved cleavage and were subsequently blocked at the
      2-cell stage. In the MI vitrification group, a total of 22 embryos were obtained,
      five of which developed to the blastocyst stage. CONCLUSIONS: Vitrification is
      superior to the slow freezing method in terms of the survival and developmental
      rates for the cryopreservation of human failed-matured oocytes. In addition, GV
      oocytes appeared to be more resistant than MI oocytes to the low temperature and 
      cryoprotectant used during cryopreservation.
FAU - Zhang, ZhiGuo
AU  - Zhang Z
AD  - Reproductive Medicine Centre, Department of Obstetrics and Gynecology, First
      Affiliated Hospital of Anhui Medical University, The People's Republic of China.
FAU - Liu, Yu
AU  - Liu Y
FAU - Xing, Qiong
AU  - Xing Q
FAU - Zhou, Ping
AU  - Zhou P
FAU - Cao, Yunxia
AU  - Cao Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111212
PL  - England
TA  - Reprod Biol Endocrinol
JT  - Reproductive biology and endocrinology : RB&E
JID - 101153627
RN  - 0 (Propylene Glycols)
RN  - 57-50-1 (Sucrose)
RN  - FC72KVT52F (Ethylene Glycol)
SB  - IM
MH  - Adult
MH  - Cell Survival
MH  - Cryopreservation/*methods
MH  - Embryo Culture Techniques
MH  - Embryonic Development
MH  - Ethylene Glycol/pharmacology
MH  - Female
MH  - Fertilization
MH  - *Freezing
MH  - Humans
MH  - Male
MH  - Oocytes/*cytology/drug effects/growth & development
MH  - Pregnancy
MH  - Propylene Glycols/pharmacology
MH  - Reproducibility of Results
MH  - Sperm Injections, Intracytoplasmic/*methods
MH  - Sucrose/pharmacology
MH  - Time Factors
PMC - PMC3253057
EDAT- 2011/12/14 06:00
MHDA- 2012/03/29 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/08/12 00:00 [received]
PHST- 2011/12/12 00:00 [accepted]
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/03/29 06:00 [medline]
AID - 1477-7827-9-156 [pii]
AID - 10.1186/1477-7827-9-156 [doi]
PST - epublish
SO  - Reprod Biol Endocrinol. 2011 Dec 12;9:156. doi: 10.1186/1477-7827-9-156.


PMID- 22151791
OWN - NLM
STAT- MEDLINE
DCOM- 20120517
LR  - 20220409
IS  - 1477-7819 (Electronic)
IS  - 1477-7819 (Linking)
VI  - 9
DP  - 2011 Dec 9
TI  - Risk factors of gallbladder cancer in Karachi-a case-control study.
PG  - 164
LID - 10.1186/1477-7819-9-164 [doi]
AB  - BACKGROUND: Gallbladder carcinoma (GC) is a relatively rare malignancy worldwide 
      but is the second commonest gastrointestinal cancer in Pakistani women.
      Gallstones have a positive association with GC but other factors also influence
      in causation. METHODS: This is a retrospective case control study over a period
      of 19 years. The cases (Group A) were patients with histopathological proven
      carcinoma gallbladder (N = 60) and controls were patients with cholelithiasis but
      no carcinoma gallbladder on histopathology (N = 120). Multivariate regression
      analysis was done to calculate the odds ratio, 95% confidence interval and
      P-Value. A positive relationship was found between size of stone > 1 cm, solitary
      stone, age > 55 years and multi-parity in women. RESULTS: There were 60 patients 
      in Group A and 120 patients in Group B. mean age of diagnosis in Group A patients
      was 57 +/- 2.4 years while mean age of diagnosis in Group B patients was 48 +/-
      1.35 years. Sixty seven percent of cancer group patients were female as compared 
      to 78% females in non-cancer group. In Group A, 69% of female patients were
      multiparous (parity of more than 5) while 43% of group B patients were
      multiparous. For body mass index (BMI), both groups were not very different in
      our study population i.e. around 78% patients in each group has BMI of more than 
      23 Kg/m2. In Group A, 37% (n = 22) have solitary stones as compared to 15% (n =
      18) in group B. similarly Group A patients has larger stone size as compared to
      Group B i.e.59% (n = 36) patients in Group A have stones of more than 1 cm when
      compared to 35% (n = 41) patients in Group B. After using multivariate regression
      analysis, age more than 55 years (OR - 7.27, p value- < 0.001), solitary stone
      (OR - 3.33, p value - 0.002) and stone of more than 1 cm (OR - 2.73, p value -
      0.004) were found to be independent risk factors for development of gallbladder
      cancer. CONCLUSION: Most of the patients (78%) with GC were female, and the
      statistically significant risk factors were older age, solitary stones and stones
      size more than one centimeter. A case can be made for prophylactic
      cholecystectomy in such a high risk group. However a population based study is
      required to calculate the true incidence of GC in Karachi and a prospective multi
      center study is needed to produce strong evidence for screening and prophylactic 
      cholecystectomy. TRIAL REGISTRATION: As this was a retrospective review of
      medical records, as per institution policy, its gives waiver from any
      registration (ethical/trial).
FAU - Alvi, A Rehman
AU  - Alvi AR
AD  - Department of Surgery, Aga Khan University Hospital, Karachi-74800, Pakistan.
      rehman.alvi@aku.edu
FAU - Siddiqui, Nadeem Ahmed
AU  - Siddiqui NA
FAU - Zafar, Hasnain
AU  - Zafar H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20111209
PL  - England
TA  - World J Surg Oncol
JT  - World journal of surgical oncology
JID - 101170544
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Cholecystectomy
MH  - Female
MH  - Follow-Up Studies
MH  - Gallbladder Neoplasms/epidemiology/*etiology
MH  - Gallstones/epidemiology/*etiology
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Pakistan/epidemiology
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Young Adult
PMC - PMC3256117
EDAT- 2011/12/14 06:00
MHDA- 2012/05/18 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/05/24 00:00 [received]
PHST- 2011/12/09 00:00 [accepted]
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/05/18 06:00 [medline]
AID - 1477-7819-9-164 [pii]
AID - 10.1186/1477-7819-9-164 [doi]
PST - epublish
SO  - World J Surg Oncol. 2011 Dec 9;9:164. doi: 10.1186/1477-7819-9-164.


PMID- 22151408
OWN - NLM
STAT- MEDLINE
DCOM- 20120813
LR  - 20220331
IS  - 1601-0825 (Electronic)
IS  - 1354-523X (Linking)
VI  - 18
IP  - 3
DP  - 2012 Apr
TI  - Translation, validation, and construct reliability of a Portuguese version of the
      Xerostomia Inventory.
PG  - 293-8
LID - 10.1111/j.1601-0825.2011.01879.x [doi]
AB  - OBJECTIVES: To generate and validate at pretest level a cross-culturally adapted 
      Portuguese version of Xerostomia Inventory (XI), a 11-item questionnaire designed
      to measure specific xerostomia rating of patients complaints. METHODS: The
      original English version of the XI was translated into Portuguese following the
      guidelines for cross-cultural adaptation of health-related quality of life
      measures. Thirty patients with primary Sjogren syndrome were recruited for this
      study. The questionnaires were administered by trained and calibrated dental
      doctors to each patient. XI properties were examined including reliability,
      internal consistency, and test-retest reliability, using Cronbach's alpha, total 
      and inter-item correlation, and intra-class correlation coefficients (ICC),
      respectively. Construct validity supported by objective measurements of
      xerostomia intra-oral signs and salivary secretion was investigated. Alpha was
      set at 0.05. Informed consents and local ethical committee clearance were
      obtained. RESULTS: Internal consistency and test-retest reliability were
      excellent (Cronbach's alpha=0.9; ICC range=0.79-0.94). Scatterplot interpolation 
      and Pearson correlation coefficient suggested the presence of a strong, negative,
      and significant correlation between salivation and the XI scores indicating
      construct validity. CONCLUSION: The Portuguese version of the XI can be
      considered a reliable and valid instrument to measure patients' xerostomia
      symptoms.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - da Mata, A D S P
AU  - da Mata AD
AD  - Oral Biology and Biochemistry Group, Biomedical and Oral Sciences Research Unit
      (FCT Unit 4062), Faculty of Dentistry, University of Lisbon, Portugal.
      admata2@yahoo.com
FAU - da Silva Marques, D N
AU  - da Silva Marques DN
FAU - Freitas, F M F
AU  - Freitas FM
FAU - de Almeida Rato Amaral, J P
AU  - de Almeida Rato Amaral JP
FAU - Trindade, R T V M R
AU  - Trindade RT
FAU - Barcelos, F A D
AU  - Barcelos FA
FAU - Vaz Patto, J M
AU  - Vaz Patto JM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20111212
PL  - Denmark
TA  - Oral Dis
JT  - Oral diseases
JID - 9508565
MH  - Cross-Cultural Comparison
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - *Language
MH  - Middle Aged
MH  - Portugal
MH  - Saliva/metabolism
MH  - Secretory Rate
MH  - Self Report
MH  - Sjogren's Syndrome/diagnosis
MH  - *Surveys and Questionnaires/standards
MH  - *Translating
MH  - Xerostomia/*diagnosis/physiopathology
EDAT- 2011/12/14 06:00
MHDA- 2012/08/14 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/08/14 06:00 [medline]
AID - 10.1111/j.1601-0825.2011.01879.x [doi]
PST - ppublish
SO  - Oral Dis. 2012 Apr;18(3):293-8. doi: 10.1111/j.1601-0825.2011.01879.x. Epub 2011 
      Dec 12.


PMID- 22150919
OWN - NLM
STAT- MEDLINE
DCOM- 20140127
LR  - 20150213
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 27
IP  - 3
DP  - 2013 Mar
TI  - Brain death in Islamic ethico-legal deliberation: challenges for applied Islamic 
      bioethics.
PG  - 132-9
LID - 10.1111/j.1467-8519.2011.01935.x [doi]
AB  - Since the 1980s, Islamic scholars and medical experts have used the tools of
      Islamic law to formulate ethico-legal opinions on brain death. These assessments 
      have varied in their determinations and remain controversial. Some juridical
      councils such as the Organization of Islamic Conferences' Islamic Fiqh Academy
      (OIC-IFA) equate brain death with cardiopulmonary death, while others such as the
      Islamic Organization of Medical Sciences (IOMS) analogize brain death to an
      intermediate state between life and death. Still other councils have repudiated
      the notion entirely. Similarly, the ethico-legal assessments are not uniform in
      their acceptance of brain-stem or whole-brain criteria for death, and
      consequently their conceptualizations of, brain death. Within the medical
      literature, and in the statements of Muslim medical professional societies, brain
      death has been viewed as sanctioned by Islamic law with experts citing the
      aforementioned rulings. Furthermore, health policies around organ transplantation
      and end-of-life care within the Muslim world have been crafted with consideration
      of these representative religious determinations made by transnational,
      legally-inclusive, and multidisciplinary councils. The determinations of these
      councils also have bearing upon Muslim clinicians and patients who encounter the 
      challenges of brain death at the bedside. For those searching for
      'Islamically-sanctioned' responses that can inform their practice, both the
      OIC-IFA and IOMS verdicts have palpable gaps in their assessments and remain
      clinically ambiguous. In this paper we analyze these verdicts from the
      perspective of applied Islamic bioethics and raise several questions that, if
      answered by future juridical councils, will better meet the needs of clinicians
      and bioethicists.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Padela, Aasim I
AU  - Padela AI
AD  - Section of Emergency Medicine, University of Chicago, IL 60637, USA.
      apadela@uchicago.edu
FAU - Arozullah, Ahsan
AU  - Arozullah A
FAU - Moosa, Ebrahim
AU  - Moosa E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111213
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
EIN - Bioethics. 2015 Jan;29(1):56
MH  - *Brain Death
MH  - *Ethics, Medical
MH  - Human Rights
MH  - Humans
MH  - *Islam
MH  - *Religion and Medicine
MH  - Terminal Care/ethics
MH  - Tissue and Organ Procurement/ethics
EDAT- 2011/12/14 06:00
MHDA- 2014/01/28 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2014/01/28 06:00 [medline]
AID - 10.1111/j.1467-8519.2011.01935.x [doi]
PST - ppublish
SO  - Bioethics. 2013 Mar;27(3):132-9. doi: 10.1111/j.1467-8519.2011.01935.x. Epub 2011
      Dec 13.


PMID- 22150828
OWN - NLM
STAT- MEDLINE
DCOM- 20131107
LR  - 20211021
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 27
IP  - 4
DP  - 2013 May
TI  - What can history do for bioethics?
PG  - 215-23
LID - 10.1111/j.1467-8519.2011.01933.x [doi]
AB  - This article details the relationship between history and bioethics. I argue that
      historians' reluctance to engage with bioethics rests on a misreading of the
      field as solely reducible to applied ethics, and overlooks previous enthusiasm
      for historical perspectives. I claim that seeing bioethics as its practitioners
      see it - as an interdisciplinary meeting ground - should encourage historians to 
      collaborate in greater numbers. I conclude by outlining how bioethics might
      benefit from new histories of the field, and how historians can lend a fresh
      perspective to bioethical debates.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Wilson, Duncan
AU  - Wilson D
AD  - University of Manchester's Centre for the History of Science, Technology and
      Medicine, Manchester, UK. duncan.wilson@manchester.ac.uk
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111213
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Bioethics/*history
MH  - *History
MH  - History, 20th Century
PMC - PMC3654172
EDAT- 2011/12/14 06:00
MHDA- 2013/11/08 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2013/11/08 06:00 [medline]
AID - 10.1111/j.1467-8519.2011.01933.x [doi]
PST - ppublish
SO  - Bioethics. 2013 May;27(4):215-23. doi: 10.1111/j.1467-8519.2011.01933.x. Epub
      2011 Dec 13.


PMID- 22150792
OWN - NLM
STAT- MEDLINE
DCOM- 20131107
LR  - 20141120
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 27
IP  - 4
DP  - 2013 May
TI  - Linking international research to global health equity: the limited contribution 
      of bioethics.
PG  - 208-14
LID - 10.1111/j.1467-8519.2011.01932.x [doi]
AB  - Health research has been identified as a vehicle for advancing global justice in 
      health. However, in bioethics, issues of global justice are mainly discussed
      within an ongoing debate on the conditions under which international clinical
      research is permissible. As a result, current ethical guidance predominantly
      links one type of international research (biomedical) to advancing one aspect of 
      health equity (access to new treatments). International guidelines largely fail
      to connect international research to promoting broader aspects of health equity -
      namely, healthier social environments and stronger health systems. Bioethical
      frameworks such as the human development approach do consider how international
      clinical research is connected to the social determinants of health but, again,
      do so to address the question of when international clinical research is
      permissible. It is suggested that the narrow focus of this debate is shaped by
      high-income countries' economic strategies. The article further argues that the
      debate's focus obscures a stronger imperative to consider how other types of
      international research might advance justice in global health. Bioethics should
      consider the need for non-clinical health research and its contribution to
      advancing global justice.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Pratt, Bridget
AU  - Pratt B
AD  - Michael Kirby Centre for Public Health and Human Rights at Monash University,
      Australia. Bridget.Pratt@monash.edu
FAU - Loff, Bebe
AU  - Loff B
LA  - eng
PT  - Journal Article
DEP - 20111213
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - *Bioethics
MH  - Biomedical Research/economics/*ethics
MH  - Developing Countries
MH  - Economics, Medical
MH  - Global Health
MH  - Health Status Disparities
MH  - Humans
MH  - *International Cooperation
MH  - *Social Justice
EDAT- 2011/12/14 06:00
MHDA- 2013/11/08 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2013/11/08 06:00 [medline]
AID - 10.1111/j.1467-8519.2011.01932.x [doi]
PST - ppublish
SO  - Bioethics. 2013 May;27(4):208-14. doi: 10.1111/j.1467-8519.2011.01932.x. Epub
      2011 Dec 13.


PMID- 22150772
OWN - NLM
STAT- MEDLINE
DCOM- 20131107
LR  - 20220330
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 27
IP  - 4
DP  - 2013 May
TI  - The ethics of sham surgery in Parkinson's disease: back to the future?
PG  - 175-85
LID - 10.1111/j.1467-8519.2011.01931.x [doi]
AB  - Despite intense academic debate in the recent past over the use of 'sham surgery'
      control groups in research, there has been a recent resurgence in their use in
      the field of neurodegenerative disease. Yet the primacy of ethical arguments in
      favour of sham surgery controls is not yet established. Preliminary empirical
      research shows an asymmetry between the views of neurosurgical researchers and
      patients on the subject, while different ethical guidelines and regulations
      support conflicting interpretations. Research ethics committees faced with a
      proposal involving sham surgery should be aware of its ethical complexities. An
      overview of recent and current placebo-controlled surgical trials in the field of
      Parkinson's Disease is provided here, followed by an analysis of the key ethical 
      issues which such trials raise.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Swift, Teresa
AU  - Swift T
AD  - Centre for Ethics in Medicine, University of Bristol, UK.
      teresa.swift@blueyonder.co.uk
FAU - Huxtable, Richard
AU  - Huxtable R
LA  - eng
GR  - 068919/Z/02/A/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111213
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Clinical Trials as Topic/*ethics/methods
MH  - Control Groups
MH  - Ethics Committees, Research
MH  - *Ethics, Clinical
MH  - Humans
MH  - Parkinson Disease/*surgery
MH  - Research Design
PMC - PMC3654166
EDAT- 2011/12/14 06:00
MHDA- 2013/11/08 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2013/11/08 06:00 [medline]
AID - 10.1111/j.1467-8519.2011.01931.x [doi]
PST - ppublish
SO  - Bioethics. 2013 May;27(4):175-85. doi: 10.1111/j.1467-8519.2011.01931.x. Epub
      2011 Dec 13.


PMID- 22150626
OWN - NLM
STAT- MEDLINE
DCOM- 20120702
LR  - 20120228
IS  - 1545-0066 (Electronic)
IS  - 1090-3127 (Linking)
VI  - 16
IP  - 2
DP  - 2012 Apr-Jun
TI  - Management of an extremely premature infant in the out-of-hospital environment.
PG  - 303-7
LID - 10.3109/10903127.2011.616258 [doi]
AB  - The rate of premature infant mortality has decreased over the last several
      decades, with an accompanying decrease in the gestational age of premature
      infants who survive to hospital discharge. Emergency medical services (EMS)
      providers are sometimes called to provide prehospital care for infants born at
      the edge of viability. Such extremely premature infants (EPIs) present medical
      and ethical challenges. In this case report, we describe an infant born at 24
      weeks into a toilet by a mother who thought she had miscarried. The EMS providers
      evaluated the infant as nonviable and placed him in a plastic bag for transport
      to a local emergency department (ED). The ED staff found the infant to have a
      bradycardic rhythm, initiated resuscitation, and admitted him to the neonatal
      intensive care unit. The infant died seven days later. We review the literature
      for recommendations in resuscitation of EPIs and discuss the ethics regarding
      their management in the prehospital setting.
FAU - Sanders, William
AU  - Sanders W
AD  - Department of Emergency Medicine, Oakland University/William Beaumont School of
      Medicine, Royal Oak, Michigan, USA.
FAU - Fringer, Ryan
AU  - Fringer R
FAU - Swor, Robert
AU  - Swor R
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20111212
PL  - England
TA  - Prehosp Emerg Care
JT  - Prehospital emergency care
JID - 9703530
SB  - IM
MH  - Abortion, Incomplete/*surgery
MH  - Adult
MH  - Ambulatory Care/*methods
MH  - Cardiopulmonary Resuscitation/methods
MH  - *Dilatation and Curettage
MH  - Emergency Treatment/methods
MH  - Fatal Outcome
MH  - Female
MH  - Gestational Age
MH  - Humans
MH  - *Infant, Extremely Low Birth Weight
MH  - Infant, Newborn
MH  - *Infant, Premature
MH  - Intensive Care Units, Neonatal
MH  - Male
MH  - Pregnancy
EDAT- 2011/12/14 06:00
MHDA- 2012/07/03 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/07/03 06:00 [medline]
AID - 10.3109/10903127.2011.616258 [doi]
PST - ppublish
SO  - Prehosp Emerg Care. 2012 Apr-Jun;16(2):303-7. doi: 10.3109/10903127.2011.616258. 
      Epub 2011 Dec 12.


PMID- 22150502
OWN - NLM
STAT- MEDLINE
DCOM- 20120529
LR  - 20181201
IS  - 1525-6049 (Electronic)
IS  - 0886-022X (Linking)
VI  - 34
IP  - 2
DP  - 2012
TI  - The effects of sevoflurane anesthesia and cardiopulmonary bypass on renal
      function in cyanotic and acyanotic children undergoing cardiac surgery.
PG  - 135-41
LID - 10.3109/0886022X.2011.641513 [doi]
AB  - BACKGROUND: There are few data on the effects of anesthesia and cardiopulmonary
      bypass (CPB) on perioperative renal function in children with cyanotic congenital
      heart disease undergoing open heart surgery. This study aims to investigate the
      perioperative renal function in cyanotic versus acyanotic children undergoing
      sevoflurane anesthesia for open heart surgery. METHODS: After receiving ethical
      committee approval, 12 acyanotic patients (preoperative oxygen saturation: SaO(2)
      > 85%) and 12 cyanotic children (SaO(2) < 85%) were included. Sevoflurane was
      administered at concentration levels of 2% before CPB and 1-2% during CPB after
      standard anesthesia induction. Inorganic fluoride, electrolytes, creatinine, urea
      nitrogen in serum and urine samples, and N-acetyl-beta-d-glucosaminidase (NAG) in
      urine samples were measured before induction, before CPB, during CPB, after CPB, 
      at the end of surgery, and at 24th h postoperatively. RESULTS: The levels of
      serum uric acid levels were higher in the cyanotic group (p < 0.05). There were
      no differences in the levels of serum creatinine and urine creatinine, urea
      nitrogen, and electrolytes between the two groups. Serum inorganic fluoride
      levels were always higher in the acyanotic group than in the cyanotic group, but 
      these differences between the groups reached statistical significance at two
      measurement times (before CPB and end of surgery) (p < 0.05). Urinary inorganic
      fluoride levels increased with time in both groups. Although urinary NAG
      increased significantly after the CPB in the cyanotic group, the differences
      between the two groups did not reach statistical significance. CONCLUSIONS: We
      have concluded that renal function was not affected during open heart surgery
      with sevoflurane anesthesia, in both cyanotic and acyanotic children.
FAU - Oc, Bahar
AU  - Oc B
AD  - Department of Anesthesiology and Reanimation, Selcuklu Faculty of Medicine,
      Selcuk University, Konya, Turkey. baharoc@selcuk.edu.tr
FAU - Akinci, Seda B
AU  - Akinci SB
FAU - Kanbak, Meral
AU  - Kanbak M
FAU - Satana, Eda
AU  - Satana E
FAU - Celebioglu, Bilge
AU  - Celebioglu B
FAU - Aypar, Ulku
AU  - Aypar U
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111212
PL  - England
TA  - Ren Fail
JT  - Renal failure
JID - 8701128
RN  - 0 (Anesthetics, Inhalation)
RN  - 0 (Methyl Ethers)
RN  - 38LVP0K73A (Sevoflurane)
SB  - IM
MH  - *Anesthesia
MH  - Anesthetics, Inhalation/*pharmacology
MH  - *Cardiac Surgical Procedures
MH  - *Cardiopulmonary Bypass
MH  - Child, Preschool
MH  - Cyanosis/*physiopathology/*surgery
MH  - Female
MH  - Heart Defects, Congenital/*physiopathology/*surgery
MH  - Humans
MH  - Kidney/*drug effects/*physiopathology
MH  - Kidney Function Tests
MH  - Male
MH  - Methyl Ethers/*pharmacology
MH  - Sevoflurane
EDAT- 2011/12/14 06:00
MHDA- 2012/05/30 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/05/30 06:00 [medline]
AID - 10.3109/0886022X.2011.641513 [doi]
PST - ppublish
SO  - Ren Fail. 2012;34(2):135-41. doi: 10.3109/0886022X.2011.641513. Epub 2011 Dec 12.


PMID- 22150179
OWN - NLM
STAT- MEDLINE
DCOM- 20120417
LR  - 20121101
IS  - 1552-4264 (Electronic)
IS  - 1552-4264 (Linking)
VI  - 7
IP  - 4
DP  - 2011
TI  - The assimilation of problematic experiences sequence: an approach to
      evidence-based practice in bereavement counseling.
PG  - 350-62
LID - 10.1080/15524256.2011.623468 [doi]
AB  - Current theories of bereavement are available and complex and suggest that for
      the bereaved there is no single pathway through grief. This challenges ethically 
      motivated bereavement counselors to integrate theory into evidence-based
      practice. The Assimilation of Problematic Experiences Sequence offers a way
      forward for evaluating the effectiveness of bereavement counseling. Parallels are
      drawn between grief as disrupted self-narrative and grief as the dissociated
      voices of unassimilated experience. This assimilation sequence is proposed as a
      means of tracking psychological change in bereaved clients.
FAU - Wilson, John
AU  - Wilson J
AD  - Saint Catherine's Hospice Bereavement Support Service, Scarborough, UK.
      john@moorsidecounselling.co.uk
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Soc Work End Life Palliat Care
JT  - Journal of social work in end-of-life & palliative care
JID - 101235219
SB  - IM
MH  - Adaptation, Psychological
MH  - *Bereavement
MH  - Counseling/*methods
MH  - Evidence-Based Practice
MH  - Humans
MH  - *Models, Psychological
MH  - Social Work/*methods
EDAT- 2011/12/14 06:00
MHDA- 2012/04/18 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/04/18 06:00 [medline]
AID - 10.1080/15524256.2011.623468 [doi]
PST - ppublish
SO  - J Soc Work End Life Palliat Care. 2011;7(4):350-62. doi:
      10.1080/15524256.2011.623468.


PMID- 22150178
OWN - NLM
STAT- MEDLINE
DCOM- 20120417
LR  - 20161125
IS  - 1552-4264 (Electronic)
IS  - 1552-4264 (Linking)
VI  - 7
IP  - 4
DP  - 2011
TI  - Cultural vulnerability and professional narratives.
PG  - 338-49
LID - 10.1080/15524256.2011.623464 [doi]
AB  - In this article the author draws upon research with palliative care professionals
      in the United Kingdom to discuss the value of a stance of cultural vulnerability 
      in intercultural care. Cultural vulnerability recognizes the reality, but also
      the ethical value of uncertainty and not-knowing in care. Attentiveness to
      professional narratives is advocated as vital in the development of greater
      understanding of cultural vulnerability and its effects. The role of cultural
      identifications and the politics of racism in social work narratives is given
      specific attention.
FAU - Gunaratnam, Yasmin
AU  - Gunaratnam Y
AD  - Department of Sociology, Goldsmiths College, University of London, New Cross,
      London, UK. y.gunaratnam@gold.ac.uk
LA  - eng
GR  - Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Soc Work End Life Palliat Care
JT  - Journal of social work in end-of-life & palliative care
JID - 101235219
SB  - IM
MH  - *Communication
MH  - *Cultural Competency
MH  - *Culture
MH  - Female
MH  - Humans
MH  - Male
MH  - Palliative Care/*methods
MH  - Prejudice
MH  - Social Work/*methods
MH  - United Kingdom
EDAT- 2011/12/14 06:00
MHDA- 2012/04/18 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/04/18 06:00 [medline]
AID - 10.1080/15524256.2011.623464 [doi]
PST - ppublish
SO  - J Soc Work End Life Palliat Care. 2011;7(4):338-49. doi:
      10.1080/15524256.2011.623464.


PMID- 22150176
OWN - NLM
STAT- MEDLINE
DCOM- 20120417
LR  - 20181201
IS  - 1552-4264 (Electronic)
IS  - 1552-4264 (Linking)
VI  - 7
IP  - 4
DP  - 2011
TI  - Health care costs in end-of-life and palliative care: the quest for ethical
      reform.
PG  - 300-17
LID - 10.1080/15524256.2011.623458 [doi]
AB  - Health reform in the United States must address both access to medical services
      and universal insurance coverage, as well as health care cost containment.
      Uncontrolled health care costs will undermine improvements in access and coverage
      in the long-run, and will also be detrimental to other important social programs 
      and goals. Accordingly, the authors offer an ethical perspective on health care
      cost control in the context of end-of-life and palliative care, an area
      considered by many to be a principal candidate for cost containment. However, the
      policy and ethical challenges may be more difficult in end-of-life care than in
      other areas of medicine. Here we discuss barriers to developing high quality,
      cost effective, and beneficial end-of-life care, and barriers to maintaining a
      system of decision making that respects the wishes and values of dying patients, 
      their families, and caregivers. The authors also consider improvements in present
      policy and practice-such as increased timely access and referral to hospice and
      palliative care; improved organizational incentives and cultural attitudes to
      reduce the use of ineffective treatments; and improved communication among health
      professionals, patients, and families in the end-of-life care planning and
      decision-making process.
FAU - Jennings, Bruce
AU  - Jennings B
AD  - Center for Humans and Nature, Dobbs Ferry, New York 10522, USA.
      brucejennings@humansandnature.org
FAU - Morrissey, Mary Beth
AU  - Morrissey MB
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Soc Work End Life Palliat Care
JT  - Journal of social work in end-of-life & palliative care
JID - 101235219
SB  - IM
MH  - Communication
MH  - Cost Control
MH  - Cost of Illness
MH  - Cost-Benefit Analysis
MH  - Cultural Competency
MH  - Health Care Costs/*statistics & numerical data
MH  - Health Care Rationing/economics/*organization & administration
MH  - *Health Care Reform
MH  - Health Personnel/organization & administration
MH  - Health Services/economics/statistics & numerical data
MH  - Humans
MH  - Medicare/economics
MH  - Palliative Care/ethics/organization & administration
MH  - Policy
MH  - Professional-Family Relations
MH  - Quality of Health Care/ethics/organization & administration
MH  - Terminal Care/economics/ethics/*organization & administration
MH  - United States
EDAT- 2011/12/14 06:00
MHDA- 2012/04/18 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/04/18 06:00 [medline]
AID - 10.1080/15524256.2011.623458 [doi]
PST - ppublish
SO  - J Soc Work End Life Palliat Care. 2011;7(4):300-17. doi:
      10.1080/15524256.2011.623458.


PMID- 22150063
OWN - NLM
STAT- MEDLINE
DCOM- 20120606
LR  - 20120625
IS  - 1557-7740 (Electronic)
IS  - 1557-7740 (Linking)
VI  - 15
IP  - 1
DP  - 2012 Jan
TI  - Organ donation after cardiac death from withdrawal of life support in patients
      with amyotrophic lateral sclerosis.
PG  - 16-9
LID - 10.1089/jpm.2011.0239 [doi]
AB  - OBJECTIVE: Donation after cardiac death (DCD) or donation of organs after removal
      of life support is an accepted means of organ retrieval that usually occurs in
      the setting of sudden illness but has not been described in people with
      progressive neurologic illness. We report DCD in two people with progressive
      amyotrophic lateral sclerosis (ALS). METHODS: Case series at an academic medical 
      center of two men with progressive ALS who underwent withdrawal of artificial
      life support, rapid cardiac death, and subsequent organ donation. The primary
      outcome was donation of organs in concordance with patient and family wishes.
      RESULTS: Both patients underwent peaceful withdrawal of life support in the
      presence of family, and multiple organs were donated. CONCLUSIONS: Patients may
      legally and ethically refuse life-sustaining care. These patients considered
      their lives to be more burdensome than beneficial near the end of their lives,
      both carefully planned the time and circumstance of their deaths, and both
      fulfilled a long-standing desire to donate their organs. This study describes a
      potential opportunity for patients with progressive neurologic illness.
FAU - Smith, Thomas J
AU  - Smith TJ
AD  - Palliative Care Program of Johns Hopkins Medicine, Baltimore, Maryland 21287,
      USA. tsmit36@jhmi.edu
FAU - Vota, Scott
AU  - Vota S
FAU - Patel, Shejal
AU  - Patel S
FAU - Ford, Timothy
AU  - Ford T
FAU - Lyckholm, Laurel
AU  - Lyckholm L
FAU - Bhushan, Anup
AU  - Bhushan A
FAU - Bobb, Barton
AU  - Bobb B
FAU - Coyne, Patrick
AU  - Coyne P
FAU - Swainey, Craig
AU  - Swainey C
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20111207
PL  - United States
TA  - J Palliat Med
JT  - Journal of palliative medicine
JID - 9808462
SB  - IM
CIN - J Palliat Med. 2012 May;15(5):505-6. PMID: 22577781
MH  - Adult
MH  - *Amyotrophic Lateral Sclerosis
MH  - *Death
MH  - *Euthanasia, Passive
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Tissue and Organ Procurement
EDAT- 2011/12/14 06:00
MHDA- 2012/06/07 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/06/07 06:00 [medline]
AID - 10.1089/jpm.2011.0239 [doi]
PST - ppublish
SO  - J Palliat Med. 2012 Jan;15(1):16-9. doi: 10.1089/jpm.2011.0239. Epub 2011 Dec 7.


PMID- 22149197
OWN - NLM
STAT- MEDLINE
DCOM- 20120611
LR  - 20220317
IS  - 1464-5165 (Electronic)
IS  - 0963-8288 (Linking)
VI  - 34
IP  - 11
DP  - 2012
TI  - Producing boundary-breaking texts on disability issues: the personal politics of 
      collaboration.
PG  - 951-8
LID - 10.3109/09638288.2011.624248 [doi]
AB  - PURPOSE: This article explores the reflection on a process of inter-collaborative
      team work to produce a photographic book on caregivers' experiences of parenting 
      their disabled children. The team of authors consisted of members with diverse
      backgrounds, including media studies, social science and photography. The purpose
      of this article was to explore and gain a deeper understanding of the process of 
      boundary breaking, one which is important if we are to develop new knowledges and
      new ways of thinking about disability. METHOD: In-depth interviews were conducted
      with all contributors to the book. RESULTS: Themes emerging from the interviews
      include the existence of different worlds, crossing boundaries, questions about
      expertise, conflicting hopes and expectations, and the ethics of anonymity.
      CONCLUSION: An account of the anxieties, the frustrations and rewarding aspects
      of the collaboration is provided. We conclude that "us" and "them" categorization
      permeates our thinking. It characterizes some of the most simplistic thinking in 
      the world of disability--able-bodied vs. disabled. In reality, there are no such 
      categories, we all reside along a highly differentiated continuum of changing
      states of impairment and health. If we open ourselves up to this reality, we can 
      meet one another and draw on one another's knowledge and experience.
FAU - Swartz, Leslie
AU  - Swartz L
AD  - Department of Psychology, Stellenbosch University, Stellenbosch, Matieland, South
      Africa. lswartz@sun.ac.za
FAU - van der Merwe, Amelia
AU  - van der Merwe A
FAU - Buckland, Angela
AU  - Buckland A
FAU - McDougall, Kathleen
AU  - McDougall K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111209
PL  - England
TA  - Disabil Rehabil
JT  - Disability and rehabilitation
JID - 9207179
SB  - IM
MH  - *Books
MH  - Caregivers
MH  - Child
MH  - *Cooperative Behavior
MH  - *Disabled Children
MH  - Humans
MH  - Interviews as Topic
MH  - Parenting
MH  - *Politics
EDAT- 2011/12/14 06:00
MHDA- 2012/06/12 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/06/12 06:00 [medline]
AID - 10.3109/09638288.2011.624248 [doi]
PST - ppublish
SO  - Disabil Rehabil. 2012;34(11):951-8. doi: 10.3109/09638288.2011.624248. Epub 2011 
      Dec 9.


PMID- 22149081
OWN - NLM
STAT- MEDLINE
DCOM- 20130204
LR  - 20220318
IS  - 1360-0451 (Electronic)
IS  - 0954-0121 (Linking)
VI  - 24
IP  - 5
DP  - 2012
TI  - Harnessing Online Peer Education (HOPE): integrating C-POL and social media to
      train peer leaders in HIV prevention.
PG  - 593-600
LID - 10.1080/09540121.2011.630355 [doi]
AB  - Novel methods, such as Internet-based interventions, are needed to combat the
      spread of HIV. While past initiatives have used the Internet to promote HIV
      prevention, the growing popularity, decreasing digital divide, and
      multi-functionality of social networking sites, such as Facebook, make this an
      ideal time to develop innovative ways to use online social networking sites to
      scale HIV prevention interventions among high-risk groups. The UCLA Harnessing
      Online Peer Education study is a longitudinal experimental study to evaluate the 
      feasibility, acceptability, and preliminary effectiveness of using social media
      for peer-led HIV prevention, specifically among African American and Latino Men
      who have Sex with Men (MSM). No curriculum currently exists to train peer leaders
      in delivering culturally aware HIV prevention messages using social media.
      Training was created that adapted the Community Popular Opinion Leader (C-POL)
      model, for use on social networking sites. Peer leaders are recruited who
      represent the target population and have experience with both social media and
      community outreach. The curriculum contains the following elements: discussion
      and role playing exercises to integrate basic knowledge of HIV/AIDS, awareness of
      sociocultural HIV/AIDS issues in the age of technology, and communication methods
      for training peer leaders in effective, interactive social media-based HIV
      prevention. Ethical issues related to Facebook and health interventions are
      integrated throughout the sessions. Training outcomes have been developed for
      long-term assessment of retention and efficacy. This is the first C-POL
      curriculum that has been adapted for use on social networking websites. Although 
      this curriculum has been used to target African-American and Latino MSM, it has
      been created to allow generalization to other high-risk groups.
FAU - Jaganath, Devan
AU  - Jaganath D
AD  - David Geffen School of Medicine, Los Angeles, CA, USA.
FAU - Gill, Harkiran K
AU  - Gill HK
FAU - Cohen, Adam Carl
AU  - Cohen AC
FAU - Young, Sean D
AU  - Young SD
LA  - eng
GR  - K01 MH090884/MH/NIMH NIH HHS/United States
GR  - K01 MH090884-01A1/MH/NIMH NIH HHS/United States
GR  - K01 MH090884-02/MH/NIMH NIH HHS/United States
GR  - P30 MH058107/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20111207
PL  - England
TA  - AIDS Care
JT  - AIDS care
JID - 8915313
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/*prevention & control
MH  - African Americans
MH  - Feasibility Studies
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - *Health Promotion
MH  - Hispanic or Latino
MH  - Homosexuality, Male
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Patient Acceptance of Health Care/*statistics & numerical data
MH  - Peer Group
MH  - *Problem-Based Learning
MH  - Sexual Behavior/*statistics & numerical data
MH  - *Social Media
PMC - PMC3342451
MID - NIHMS334595
EDAT- 2011/12/14 06:00
MHDA- 2013/02/05 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2013/02/05 06:00 [medline]
AID - 10.1080/09540121.2011.630355 [doi]
PST - ppublish
SO  - AIDS Care. 2012;24(5):593-600. doi: 10.1080/09540121.2011.630355. Epub 2011 Dec
      7.


PMID- 22148175
OWN - NLM
STAT- MEDLINE
DCOM- 20120517
LR  - 20220210
IS  - 0022-0124 (Print)
IS  - 0022-0124 (Linking)
VI  - 43
IP  - 3
DP  - 2012 Mar
TI  - Asking questions and appreciating inquiry: a winning strategy for the nurse
      educator and professional nurse learner.
PG  - 106-10; quiz 111-2
LID - 10.3928/00220124-20111201-01 [doi]
AB  - This article explores "asking questions" as an effective teaching-learning
      strategy and endorses a culture that facilitates asking questions to promote
      ethical and clinical reasoning to keep patients safe and improve care. Nurse
      educators who appreciate the use of empowering, thoughtful questions in
      provocative ways can encourage learners to become astute thinkers and innovative 
      problem solvers. Asking questions teaches learners to argue their thoughts,
      ideas, and decisions persuasively and ultimately to realize that is it not the
      right answer that counts as much as asking the right question.
CI  - Copyright 2012, SLACK Incorporated.
FAU - Nickitas, Donna M
AU  - Nickitas DM
AD  - Hunter-Bellevue School of Nursing, City University of New York, New York, NY,
      USA. dnickita@hunter.cuny.edu
LA  - eng
PT  - Journal Article
DEP - 20111208
PL  - United States
TA  - J Contin Educ Nurs
JT  - Journal of continuing education in nursing
JID - 0262321
MH  - Education, Nursing/*methods
MH  - Education, Nursing, Continuing
MH  - *Faculty, Nursing
MH  - Humans
MH  - *Learning
MH  - Power, Psychological
MH  - *Problem Solving
MH  - Students, Nursing/*psychology
EDAT- 2011/12/14 06:00
MHDA- 2012/05/18 06:00
CRDT- 2011/12/14 06:00
PHST- 2011/09/15 00:00 [received]
PHST- 2011/11/08 00:00 [accepted]
PHST- 2011/12/14 06:00 [entrez]
PHST- 2011/12/14 06:00 [pubmed]
PHST- 2012/05/18 06:00 [medline]
AID - 10.3928/00220124-20120223-68 [doi]
PST - ppublish
SO  - J Contin Educ Nurs. 2012 Mar;43(3):106-10; quiz 111-2. doi:
      10.3928/00220124-20120223-68. Epub 2011 Dec 8.


PMID- 29062723
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2225-2002 (Print)
IS  - 2225-2002 (Linking)
VI  - 1
IP  - 1
DP  - 2012
TI  - Review and comparison of quality standards, guidelines and regulations for
      laboratories.
PG  - 3
LID - 10.4102/ajlm.v1i1.3 [doi]
AB  - BACKGROUND: The variety and number of laboratory quality standards, guidelines
      and regulations (hereafter: quality documents) makes it difficult to choose the
      most suitable one for establishing and maintaining a laboratory quality
      management system. OBJECTIVES: There is a need to compare the characteristics,
      suitability and applicability of quality documents in view of the increasing
      efforts to introduce quality management in laboratories, especially in clinical
      diagnostic laboratories in low income and middle income countries. This may
      provide valuable insights for policy makers developing national laboratory
      policies, and for laboratory managers and quality officers in choosing the most
      appropriate quality document for upgrading their laboratories. METHOD: We
      reviewed the history of quality document development and then selected a subset
      based on their current use. We analysed these documents following a framework for
      comparison of quality documents that was adapted from the Clinical Laboratory
      Standards Institute guideline GP26 Quality management system model for clinical
      laboratory services. RESULTS: Differences were identified between national and
      international, and non-clinical and clinical quality documents. The most salient 
      findings were the absence of provisions on occurrence management and customer
      service in almost all non-clinical quality documents, a low number of safety
      requirements aimed at protecting laboratory personnel in international quality
      documents and no requirements regarding ethical behaviour in almost all quality
      documents. CONCLUSION: Each laboratory needs to investigate whether national
      regulatory standards are present. These are preferred as they most closely suit
      the needs of laboratories in the country. A laboratory should always use both a
      standard and a guideline: a standard sums up the requirements to a quality
      management system, a guideline describes how quality management can be integrated
      in the laboratory processes.
FAU - Datema, Tjeerd A M
AU  - Datema TAM
AD  - KIT Biomedical Research, Royal Tropical Institute, Amsterdam, The Netherlands.
FAU - Oskam, Linda
AU  - Oskam L
AD  - KIT Biomedical Research, Royal Tropical Institute, Amsterdam, The Netherlands.
FAU - Klatser, Paul R
AU  - Klatser PR
AD  - KIT Biomedical Research, Royal Tropical Institute, Amsterdam, The Netherlands.
AD  - Athena Institute, VU University Amsterdam, Amsterdam, The Netherlands.
AD  - Amsterdam Institute for Global Health and Development, Academic Medical Centre of
      the University of Amsterdam, Amsterdam, The Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20111213
PL  - South Africa
TA  - Afr J Lab Med
JT  - African journal of laboratory medicine
JID - 101603205
PMC - PMC5644525
COIS- The authors declare that they have no financial or personal relationship(s),
      which may have inappropriately influenced them in writing this article.
EDAT- 2011/12/13 00:00
MHDA- 2011/12/13 00:01
CRDT- 2017/10/25 06:00
PHST- 2011/05/26 00:00 [received]
PHST- 2011/11/11 00:00 [accepted]
PHST- 2017/10/25 06:00 [entrez]
PHST- 2011/12/13 00:00 [pubmed]
PHST- 2011/12/13 00:01 [medline]
AID - 10.4102/ajlm.v1i1.3 [doi]
AID - AJLM-1-3 [pii]
PST - epublish
SO  - Afr J Lab Med. 2011 Dec 13;1(1):3. doi: 10.4102/ajlm.v1i1.3. eCollection 2012.


PMID- 22147947
OWN - NLM
STAT- MEDLINE
DCOM- 20120711
LR  - 20161125
IS  - 1527-1927 (Electronic)
IS  - 0361-6878 (Linking)
VI  - 37
IP  - 2
DP  - 2012 Apr
TI  - A consideration of user financial incentives to address health inequalities.
PG  - 201-26
LID - 10.1215/03616878-1538602 [doi]
AB  - Health inequalities and user financial incentives to encourage health-related
      behavior change are two topical issues in the health policy discourse, and this
      article attempts to combine the two; namely, we try to address whether the latter
      can be used to reduce the former in the contexts of the United Kingdom and the
      United States. Payments for some aspects of medical adherence may offer a
      promising way to address, to some extent, inequalities in health and health care 
      in both countries. However, payments for more sustained behavior change, such as 
      that associated with smoking cessation and weight loss, have thus far shown
      little long-term effect, although more research that tests the effectiveness of
      different incentive mechanism designs, informed by the findings of behavioral
      economics, ought to be undertaken. Many practical, political, ethical, and
      ideological objections can be waged against user financial incentives in health, 
      and this article reviews a number of them, but the justifiability of and limits
      to these incentives require more academic and public discourse so as to gain a
      better understanding of the circumstances in which they can legitimately be used.
FAU - Oliver, Adam
AU  - Oliver A
AD  - London School of Economics.
FAU - Brown, Lawrence D
AU  - Brown LD
LA  - eng
PT  - Journal Article
DEP - 20111205
PL  - United States
TA  - J Health Polit Policy Law
JT  - Journal of health politics, policy and law
JID - 7609331
SB  - IM
MH  - *Health Behavior
MH  - Health Policy/*economics
MH  - Healthcare Disparities/*economics
MH  - Humans
MH  - Motivation
MH  - Socioeconomic Factors
MH  - United Kingdom
MH  - United States
EDAT- 2011/12/08 06:00
MHDA- 2012/07/12 06:00
CRDT- 2011/12/08 06:00
PHST- 2011/12/08 06:00 [entrez]
PHST- 2011/12/08 06:00 [pubmed]
PHST- 2012/07/12 06:00 [medline]
AID - 03616878-1538602 [pii]
AID - 10.1215/03616878-1538602 [doi]
PST - ppublish
SO  - J Health Polit Policy Law. 2012 Apr;37(2):201-26. doi: 10.1215/03616878-1538602. 
      Epub 2011 Dec 5.


PMID- 22147821
OWN - NLM
STAT- MEDLINE
DCOM- 20120130
LR  - 20220321
IS  - 1931-3543 (Electronic)
IS  - 0012-3692 (Linking)
VI  - 140
IP  - 6
DP  - 2011 Dec
TI  - The ethics and reality of rationing in medicine.
PG  - 1625-1632
LID - S0012-3692(11)60662-4 [pii]
LID - 10.1378/chest.11-0622 [doi]
AB  - Rationing is the allocation of scarce resources, which in health care necessarily
      entails withholding potentially beneficial treatments from some individuals.
      Rationing is unavoidable because need is limitless and resources are not. How
      rationing occurs is important because it not only affects individual lives but
      also expresses society's most important values. This article discusses the
      following topics: (1) the inevitability of rationing of social goods, including
      medical care; (2) types of rationing; (3) ethical principles and procedures for
      fair allocation; and (4) whether rationing ICU care to those near the end of life
      would result in substantial cost savings.
FAU - Scheunemann, Leslie P
AU  - Scheunemann LP
AD  - Division of Geriatric Medicine and Center for Aging and Health, University of
      North Carolina Hospitals, Chapel Hill, NC; Department of Critical Care Medicine, 
      University of Pittsburgh Medical Center, Pittsburgh, PA.
FAU - White, Douglas B
AU  - White DB
AD  - Division of Geriatric Medicine and Center for Aging and Health, University of
      North Carolina Hospitals, Chapel Hill, NC; Program on Ethics and Decision Making 
      in Critical Illness, University of Pittsburgh Medical Center, Pittsburgh, PA;
      Department of Critical Care Medicine, University of Pittsburgh Medical Center,
      Pittsburgh, PA; Center for Bioethics and Health Law, University of Pittsburgh,
      Pittsburgh, PA. Electronic address: whitedb@upmc.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Chest
JT  - Chest
JID - 0231335
SB  - IM
MH  - Clinical Medicine/economics
MH  - Delivery of Health Care/ethics/standards
MH  - Ethics, Medical
MH  - Health Care Rationing/*ethics
MH  - Humans
MH  - *Quality of Health Care
MH  - Resource Allocation/ethics
MH  - *Social Justice
MH  - United States
PMC - PMC3415127
EDAT- 2011/12/08 06:00
MHDA- 2012/01/31 06:00
CRDT- 2011/12/08 06:00
PHST- 2011/12/08 06:00 [entrez]
PHST- 2011/12/08 06:00 [pubmed]
PHST- 2012/01/31 06:00 [medline]
AID - S0012-3692(11)60662-4 [pii]
AID - 10.1378/chest.11-0622 [doi]
PST - ppublish
SO  - Chest. 2011 Dec;140(6):1625-1632. doi: 10.1378/chest.11-0622.


PMID- 22147744
OWN - NLM
STAT- MEDLINE
DCOM- 20130104
LR  - 20220321
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 5
DP  - 2012 May
TI  - Ethics, human rights and HIV vaccine trials in low-income settings.
PG  - 286-93
LID - 10.1136/medethics-2011-100227 [doi]
AB  - The massive growth in global health research in past decades has posed many
      challenges for its effective ethical oversight, not least of which is how best to
      provide effective protection of research participants. The extent of the HIV
      epidemic in sub-Saharan Africa in particular makes research into prevention
      technologies for HIV, including HIV vaccine research, a global priority. However,
      the need for vaccine research must be considered in conjunction with the
      individual's right to informed consent, which is based on the principle of
      respect for autonomy. One of the primary human rights violations likely to occur 
      in the context of HIV vaccine research is that potential research participants
      may not fully understand what participation in research studies entails. People
      who elect to enrol in HIV vaccine trials are required to understand both the
      potential negative effects of participation (eg, discrimination) as well as
      complex scientific concepts such as randomisation and prophylaxis in order to be 
      ethically enrolled. In this study, two vignettes are presented to illustrate two 
      core issues in conducting phase III HIV vaccine trials in low-income
      countries-namely, (1) from the perspective of participants, the extent to which
      understanding is a prerequisite for consenting to participate in a trial, and (2)
      from the perspective of trial investigators, whether it is appropriate to
      persuade eligible people to enrol in a trial, even though their initial reaction 
      is to decline to participate. These vignettes are used to analyse these issues
      through the prisms of research ethics and human rights in order to identify
      helpful synergies. It is argued that the human rights perspective provides a
      helpful lens on ethical issues.
FAU - London, Leslie
AU  - London L
AD  - University of Cape Town Health Sciences Faculty, Cape Town, South Africa.
FAU - Kagee, Ashraf
AU  - Kagee A
FAU - Moodley, Keymanthri
AU  - Moodley K
FAU - Swartz, Leslie
AU  - Swartz L
LA  - eng
PT  - Journal Article
DEP - 20111206
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
RN  - 0 (AIDS Vaccines)
SB  - IM
MH  - *AIDS Vaccines
MH  - Africa South of the Sahara
MH  - Clinical Trials, Phase III as Topic/*ethics
MH  - Coercion
MH  - *Comprehension
MH  - Ethics, Research
MH  - *Human Rights
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Persuasive Communication
MH  - *Poverty
MH  - *Research Subjects
MH  - Social Justice
MH  - Vulnerable Populations/psychology
EDAT- 2011/12/08 06:00
MHDA- 2013/01/05 06:00
CRDT- 2011/12/08 06:00
PHST- 2011/12/08 06:00 [entrez]
PHST- 2011/12/08 06:00 [pubmed]
PHST- 2013/01/05 06:00 [medline]
AID - medethics-2011-100227 [pii]
AID - 10.1136/medethics-2011-100227 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 May;38(5):286-93. doi: 10.1136/medethics-2011-100227. Epub
      2011 Dec 6.


PMID- 22147674
OWN - NLM
STAT- MEDLINE
DCOM- 20120406
LR  - 20220331
IS  - 1545-5017 (Electronic)
IS  - 1545-5009 (Linking)
VI  - 58
IP  - 4
DP  - 2012 Apr
TI  - Pediatric oncology research in low income countries: ethical concepts and
      challenges.
PG  - 492-7
LID - 10.1002/pbc.23419 [doi]
AB  - Uneven strides in research and care have led to discrepancies in childhood cancer
      outcomes between high and low income countries (LICs). Collaborative research may
      help improve outcomes in LICs by generating knowledge for local scientific
      communities, augmenting knowledge translation, and fostering context-specific
      evaluation of treatment protocols. However, the risks of such research have
      received little attention. This paper investigates the relationship between
      pediatric oncology research in LICs and four core issues in the ethics
      literature: standard of care, trial benefits, ethics review, and informed
      consent. Our aims are to highlight the importance of this field and the need for 
      further inquiry.
CI  - Copyright (c) 2011 Wiley Periodicals, Inc.
FAU - Denburg, Avram E
AU  - Denburg AE
AD  - Division of Haematology/Oncology, Department of Pediatric Oncology, The Hospital 
      for Sick Children, Toronto, Ontario, Canada.
FAU - Joffe, Steven
AU  - Joffe S
FAU - Gupta, Sumit
AU  - Gupta S
FAU - Howard, Scott C
AU  - Howard SC
FAU - Ribeiro, Raul C
AU  - Ribeiro RC
FAU - Antillon, Federico A
AU  - Antillon FA
FAU - Vasquez, Roberto
AU  - Vasquez R
FAU - Sung, Lillian
AU  - Sung L
LA  - eng
GR  - 87719/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20111206
PL  - United States
TA  - Pediatr Blood Cancer
JT  - Pediatric blood & cancer
JID - 101186624
SB  - IM
MH  - *Bioethics
MH  - *Biomedical Research/economics/ethics
MH  - Child
MH  - Child, Preschool
MH  - Developing Countries/*economics
MH  - Female
MH  - Humans
MH  - Male
MH  - *Medical Oncology/economics/ethics
EDAT- 2011/12/08 06:00
MHDA- 2012/04/07 06:00
CRDT- 2011/12/08 06:00
PHST- 2011/06/27 00:00 [received]
PHST- 2011/10/12 00:00 [accepted]
PHST- 2011/12/08 06:00 [entrez]
PHST- 2011/12/08 06:00 [pubmed]
PHST- 2012/04/07 06:00 [medline]
AID - 10.1002/pbc.23419 [doi]
PST - ppublish
SO  - Pediatr Blood Cancer. 2012 Apr;58(4):492-7. doi: 10.1002/pbc.23419. Epub 2011 Dec
      6.


PMID- 22147652
OWN - NLM
STAT- MEDLINE
DCOM- 20120424
LR  - 20120222
IS  - 1531-4995 (Electronic)
IS  - 0023-852X (Linking)
VI  - 122
IP  - 3
DP  - 2012 Mar
TI  - Temporoparietal fascia free flap for pharyngeal coverage after salvage total
      laryngectomy.
PG  - 523-7
LID - 10.1002/lary.22477 [doi]
AB  - OBJECTIVES/HYPOTHESIS: The aim of this study was to assess whether the use of the
      temporoparietal fascia as a free flap for pharyngeal closure reinforcement
      reduced the incidence of pharyngocutaneous fistula (PCF) in the salvage setting. 
      STUDY DESIGN: Consecutive case series. METHODS: After research ethics board
      approval, 12 patients who required salvage laryngectomy, including reinforcement 
      coverage of the primarily closed pharyngeal defect with temporoparietal fascia as
      a free tissue transfer, were analyzed. RESULTS: One (8%) out of 12 patients
      experienced pharyngocutaneous fistula that responded with conservative wound
      packing. CONCLUSIONS: The PCF rate of 8% is significantly better than in similar 
      salvage cases without flap coverage. Moreover, our PCF rate is comparable to the 
      results shown for the pectoralis major muscle flap. The most obvious benefit of
      the temporoparietal fascia free flap for pharyngeal coverage in salvage
      laryngectomy is a reduced PCF rate with diminished donor-site morbidity,
      including cosmetic outcome, shoulder girdle function, and chest deformity.
CI  - Copyright (c) 2011 The American Laryngological, Rhinological, and Otological
      Society, Inc.
FAU - Higgins, Kevin M
AU  - Higgins KM
AD  - the Department of Otolaryngology-Head and Neck Surgery, Sunnybrook Health
      Sciences Centre, Toronto, Ontario, Canada. kevin.higgins@sunnybrook.ca
FAU - Ashford, Bruce
AU  - Ashford B
FAU - Erovic, Boban M
AU  - Erovic BM
FAU - Yoo, John
AU  - Yoo J
FAU - Enepekides, Danny J
AU  - Enepekides DJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20111206
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cutaneous Fistula/epidemiology/etiology/*prevention & control
MH  - Fascia/*transplantation
MH  - Follow-Up Studies
MH  - *Free Tissue Flaps
MH  - Humans
MH  - Incidence
MH  - Laryngectomy/*methods
MH  - Male
MH  - Middle Aged
MH  - Ontario/epidemiology
MH  - Postoperative Period
MH  - Reconstructive Surgical Procedures/*methods
MH  - Respiratory Tract Fistula/epidemiology/etiology/*prevention & control
MH  - Retrospective Studies
MH  - *Salvage Therapy
MH  - Treatment Outcome
EDAT- 2011/12/08 06:00
MHDA- 2012/04/25 06:00
CRDT- 2011/12/08 06:00
PHST- 2011/10/02 00:00 [received]
PHST- 2011/10/24 00:00 [revised]
PHST- 2011/11/01 00:00 [accepted]
PHST- 2011/12/08 06:00 [entrez]
PHST- 2011/12/08 06:00 [pubmed]
PHST- 2012/04/25 06:00 [medline]
AID - 10.1002/lary.22477 [doi]
PST - ppublish
SO  - Laryngoscope. 2012 Mar;122(3):523-7. doi: 10.1002/lary.22477. Epub 2011 Dec 6.


PMID- 22147279
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1868-6001 (Electronic)
IS  - 1868-310X (Linking)
VI  - 3
IP  - 2
DP  - 2012 Apr
TI  - Biobank governance: heterogeneous modes of ordering and democratization.
PG  - 61-72
LID - 10.1007/s12687-011-0070-0 [doi]
AB  - The great interest in biobanks, the related, substantial investments, and the
      expectations connected with them raises the question of how to explain the
      relative successes and failures of contemporary biobank projects. In this article
      we will present and discuss areas that need ongoing attention by many
      stakeholders in order stabilize and utilize biobanks and biobank networks in the 
      future. Our aim is to present and utilize an analytical model for comparing
      structures of biobank governance. The governance model we deduce from empirical
      case studies is not a well-ordered, almost bureaucratic type of government. The
      patchwork character and the interrelatedness of heterogeneous activities that
      constitute biobank governance in its multiple dimensions will be highlighted.
      Biobank governance should therefore be understood as strategy for patterning a
      network of interaction that unfolds within and across a number of different
      fields including a variety of activities that go beyond regulatory activities:
      the scientific/technological field, the medical/health field, the
      industrial-economic field, the legal-ethical, and the sociopolitical field. Our
      account emphasizes that biobanks are not technical visions that operate vis-a-vis
      an external society. The article discusses attempts to develop participatory
      governance structures. It concludes that facilitating and managing the
      integration of a network of more or less interrelated actors, in many
      nonhierarchic ways, should not be equated with democratization per se, but can
      nevertheless be regarded as an important step towards a more pluralistic and
      inclusive style of policy making.
FAU - Gottweis, Herbert
AU  - Gottweis H
AD  - Life Science Governance Research Platform/Department of Political Science,
      University of Vienna, Universitatsstr. 7 (NIG 2.Stock), 1010, Vienna, Austria,
      herbert.gottweis@univie.ac.at.
FAU - Lauss, Georg
AU  - Lauss G
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
DEP - 20111207
PL  - Germany
TA  - J Community Genet
JT  - Journal of community genetics
JID - 101551501
PMC - PMC3312942
EDAT- 2011/12/08 06:00
MHDA- 2011/12/08 06:01
CRDT- 2011/12/08 06:00
PHST- 2011/07/05 00:00 [received]
PHST- 2011/10/17 00:00 [accepted]
PHST- 2011/12/08 06:00 [entrez]
PHST- 2011/12/08 06:00 [pubmed]
PHST- 2011/12/08 06:01 [medline]
AID - 10.1007/s12687-011-0070-0 [doi]
PST - ppublish
SO  - J Community Genet. 2012 Apr;3(2):61-72. doi: 10.1007/s12687-011-0070-0. Epub 2011
      Dec 7.


PMID- 22147060
OWN - NLM
STAT- MEDLINE
DCOM- 20130402
LR  - 20121002
IS  - 1461-7277 (Electronic)
IS  - 1359-1053 (Linking)
VI  - 17
IP  - 7
DP  - 2012 Oct
TI  - The association between ethnic identity and sexual coercion among young men in
      the Eastern Cape Province, South Africa.
PG  - 1089-94
LID - 10.1177/1359105311431174 [doi]
AB  - Sexual coercion by males poses important ethical, legal and public health
      challenges. Individual face-to-face structured interviews were conducted among
      1656 men who had undergone male initiation and circumcision in rural areas of the
      Eastern Cape Province. Overall, 8.4 per cent of the participants reported ever
      having forced someone to have sex. Logistic regression adjusting for age, working
      status, education level and nation of origin showed that participants that
      expressed high cultural affiliation were significantly less likely to sexually
      coerce someone. The findings suggest that emphasizing cultural commitment may
      reduce sexual coercion, though findings need to be replicated.
FAU - Nyembezi, Anam
AU  - Nyembezi A
AD  - Medical Research Council, South Africa. anam.nyembezi@mrc.ac.za
FAU - Resnicow, Ken
AU  - Resnicow K
FAU - James, Shegs
AU  - James S
FAU - Funani, Itumeleng
AU  - Funani I
FAU - Sifunda, Sibusiso
AU  - Sifunda S
FAU - Ruiter, Robert A C
AU  - Ruiter RA
FAU - van den Borne, Bart
AU  - van den Borne B
FAU - Sanders-Phillips, Kathy
AU  - Sanders-Phillips K
FAU - Reddy, Priscilla
AU  - Reddy P
LA  - eng
PT  - Journal Article
DEP - 20111206
PL  - England
TA  - J Health Psychol
JT  - Journal of health psychology
JID - 9703616
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Coercion
MH  - Cross-Sectional Studies
MH  - Cultural Characteristics
MH  - Dominance-Subordination
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Rural Population
MH  - Sexual Behavior/*ethnology
MH  - *Social Identification
MH  - South Africa/ethnology
MH  - Young Adult
EDAT- 2011/12/08 06:00
MHDA- 2013/04/03 06:00
CRDT- 2011/12/08 06:00
PHST- 2011/12/08 06:00 [entrez]
PHST- 2011/12/08 06:00 [pubmed]
PHST- 2013/04/03 06:00 [medline]
AID - 1359105311431174 [pii]
AID - 10.1177/1359105311431174 [doi]
PST - ppublish
SO  - J Health Psychol. 2012 Oct;17(7):1089-94. doi: 10.1177/1359105311431174. Epub
      2011 Dec 6.


PMID- 22146882
OWN - NLM
STAT- MEDLINE
DCOM- 20120612
LR  - 20220331
IS  - 1534-4681 (Electronic)
IS  - 1068-9265 (Linking)
VI  - 19
IP  - 3
DP  - 2012 Mar
TI  - Oncology health information quality on the Internet: a multilingual evaluation.
PG  - 706-13
LID - 10.1245/s10434-011-2137-x [doi]
AB  - BACKGROUND: Oncologic Internet information quality is considered variable, but no
      comprehensive analysis exists to support this. We compared the quality of common 
      malignancy Web sites to assess them for language or disease differences and to
      perform a quality comparison between medical and layperson terminology. METHODS: 
      World Health Organization Health on the Net (HON) principles may be applied to
      Web sites by using an automated toolbar function. We used the Google search
      engine ( http://www.google.com ) to assess 10,200 Web sites using the keywords
      "Breast," "Colorectal," "Stomach," "Liver," "Pancreas," "Bile Duct," "Melanoma," 
      and "Thyroid," plus "cancer," in English, French, German, and Spanish. The
      searches were then repeated with alternative terms, such as "Bowel" and "Skin
      cancer." RESULTS: Less than a quarter of Web sites are HON accredited, with
      significant differences by malignancy type (P < 0.0001), language (P < 0.0001),
      and tertiles of the first 150 Web sites returned (P < 0.0001). French-language
      queries resulted in the most accredited Web sites returned. The use of
      alternative terms resulted in marked differences in accredited Web sites for
      hepatobiliary cancers. CONCLUSIONS: A lack of validation of most oncologic sites 
      is present, with discrepancies in the quality and number of Web sites across
      diseases and languages, as well as medical and alternative terms. Physicians
      should encourage and participate in the development of informative, ethical, and 
      reliable health Web sites on the Internet and direct patients to them.
FAU - Lawrentschuk, Nathan
AU  - Lawrentschuk N
AD  - Ludwig Institute for Cancer Research, Austin Hospital, Melbourne, Australia.
      lawrentschuk@gmail.com
FAU - Sasges, Deborah
AU  - Sasges D
FAU - Tasevski, Robert
AU  - Tasevski R
FAU - Abouassaly, Robert
AU  - Abouassaly R
FAU - Scott, Andrew M
AU  - Scott AM
FAU - Davis, Ian D
AU  - Davis ID
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20111207
PL  - United States
TA  - Ann Surg Oncol
JT  - Annals of surgical oncology
JID - 9420840
SB  - IM
CIN - Ann Surg Oncol. 2012 Mar;19(3):701-2. PMID: 22109732
MH  - Humans
MH  - Information Services/*standards
MH  - Internet/*standards
MH  - Multilingualism
MH  - *Neoplasms
MH  - Patient Education as Topic/*standards
MH  - Quality Control
MH  - Search Engine
MH  - World Health Organization
EDAT- 2011/12/08 06:00
MHDA- 2012/06/13 06:00
CRDT- 2011/12/08 06:00
PHST- 2011/03/17 00:00 [received]
PHST- 2011/12/08 06:00 [entrez]
PHST- 2011/12/08 06:00 [pubmed]
PHST- 2012/06/13 06:00 [medline]
AID - 10.1245/s10434-011-2137-x [doi]
PST - ppublish
SO  - Ann Surg Oncol. 2012 Mar;19(3):706-13. doi: 10.1245/s10434-011-2137-x. Epub 2011 
      Dec 7.


PMID- 22146737
OWN - NLM
STAT- MEDLINE
DCOM- 20120417
LR  - 20211021
IS  - 1438-8871 (Electronic)
IS  - 1438-8871 (Linking)
VI  - 13
IP  - 4
DP  - 2011 Dec 6
TI  - Ethical principles for physician rating sites.
PG  - e113
LID - 10.2196/jmir.1899 [doi]
AB  - During the last 5 years, an ethical debate has emerged, often in public media,
      about the potential positive and negative effects of physician rating sites and
      whether physician rating sites created by insurance companies or government
      agencies are ethical in their current states. Due to the lack of direct evidence 
      of physician rating sites' effects on physicians' performance, patient outcomes, 
      or the public's trust in health care, most contributions refer to normative
      arguments, hypothetical effects, or indirect evidence. This paper aims, first, to
      structure the ethical debate about the basic concept of physician rating sites:
      allowing patients to rate, comment, and discuss physicians' performance, online
      and visible to everyone. Thus, it provides a more thorough and transparent
      starting point for further discussion and decision making on physician rating
      sites: what should physicians and health policy decision makers take into account
      when discussing the basic concept of physician rating sites and its possible
      implications on the physician-patient relationship? Second, it discusses where
      and how the preexisting evidence from the partly related field of public
      reporting of physician performance can serve as an indicator for specific needs
      of evaluative research in the field of physician rating sites. This paper defines
      the ethical principles of patient welfare, patient autonomy, physician welfare,
      and social justice in the context of physician rating sites. It also outlines
      basic conditions for a fair decision-making process concerning the implementation
      and regulation of physician rating sites, namely, transparency, justification,
      participation, minimization of conflicts of interest, and openness for revision. 
      Besides other issues described in this paper, one trade-off presents a special
      challenge and will play an important role when deciding about more- or
      less-restrictive physician rating sites regulations: the potential psychological 
      and financial harms for physicians that can result from physician rating sites
      need to be contained without limiting the potential benefits for patients with
      respect to health, health literacy, and equity.
FAU - Strech, Daniel
AU  - Strech D
AD  - Institute for History, Ethics and Philosophy of Medicine, CELLS - Centre for
      Ethics and Law in the Life Sciences, Hannover Medical School, Hannover, Germany. 
      strech.daniel@mh-hannover.de
LA  - eng
PT  - Journal Article
DEP - 20111206
PL  - Canada
TA  - J Med Internet Res
JT  - Journal of medical Internet research
JID - 100959882
SB  - IM
CIN - Indian J Med Ethics. 2012 Apr-Jun;9(2):130-1. PMID: 22591879
MH  - Decision Making
MH  - Health Literacy/ethics
MH  - Humans
MH  - Internet/*ethics/legislation & jurisprudence
MH  - *Patient Satisfaction
MH  - Physician-Patient Relations/*ethics
MH  - Social Justice/ethics
PMC - PMC3278099
EDAT- 2011/12/08 06:00
MHDA- 2012/04/18 06:00
CRDT- 2011/12/08 06:00
PHST- 2011/07/29 00:00 [received]
PHST- 2011/10/25 00:00 [accepted]
PHST- 2011/10/21 00:00 [revised]
PHST- 2011/12/08 06:00 [entrez]
PHST- 2011/12/08 06:00 [pubmed]
PHST- 2012/04/18 06:00 [medline]
AID - v13i4e113 [pii]
AID - 10.2196/jmir.1899 [doi]
PST - epublish
SO  - J Med Internet Res. 2011 Dec 6;13(4):e113. doi: 10.2196/jmir.1899.


PMID- 22146537
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2045-9912 (Electronic)
IS  - 2045-9912 (Linking)
VI  - 1
IP  - 1
DP  - 2011 May 18
TI  - Early cognitive function, recovery and well-being after sevoflurane and xenon
      anaesthesia in the elderly: a double-blinded randomized controlled trial.
PG  - 9
LID - 10.1186/2045-9912-1-9 [doi]
AB  - BACKGROUND: The postoperative cognitive function is impaired in elderly patients 
      after general anaesthesia. The fast recovery after xenon anaesthesia was
      hypothesized to be advantageous in this scenario. We compared early postoperative
      cognitive function after xenon and sevoflurane anaesthesia in this study.
      METHODS: The study was approved by the local ethics committee and written
      informed consent was obtained from each patient. Patients aged 65-75 years (ASA
      I-III) scheduled for elective surgery (duration 60-180 min) were enrolled.
      Investigators performing cognitive testing and patients were blinded towards
      allocation to either xenon or sevoflurane anaesthesia. Baseline assessment of
      cognitive function was carried out 12-24 h before the operation. The results were
      compared to follow-up tests 6-12 and 66-72 h after surgery. Primary outcome
      parameter was the subtest "Alertness" of the computerized Test of Attentional
      Performance (TAP). Secondary outcome parameters included further subtests of the 
      TAP, several Paper-Pencil-Tests, emergence times from anaesthesia, modified
      Aldrete scores and patients' well-being. RESULTS: 40 patients were randomized and
      equally allocated to both groups. No significant differences were found in the
      TAP or the Paper-Pencil-Tests at 6-12 and 66-72 h after the operation. All
      emergence times were faster after xenon anaesthesia. The modified Aldrete scores 
      were significantly higher during the first hour in the xenon group. No difference
      in well-being could be detected between both groups. CONCLUSIONS: The results
      show no difference in the incidence of postoperative cognitive dysfunction (POCD)
      after xenon or sevoflurane anaesthesia. Emergence from general anaesthesia was
      faster in the xenon group.
FAU - Cremer, Jan
AU  - Cremer J
AD  - Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen,
      Pauwelsstrasse 30, D-52074 Aachen, Germany. mcoburn@ukaachen.de.
FAU - Stoppe, Christian
AU  - Stoppe C
FAU - Fahlenkamp, Astrid V
AU  - Fahlenkamp AV
FAU - Schalte, Gereon
AU  - Schalte G
FAU - Rex, Steffen
AU  - Rex S
FAU - Rossaint, Rolf
AU  - Rossaint R
FAU - Coburn, Mark
AU  - Coburn M
LA  - eng
PT  - Journal Article
DEP - 20110518
PL  - Australia
TA  - Med Gas Res
JT  - Medical gas research
JID - 101564536
PMC - PMC3231879
EDAT- 2011/12/08 06:00
MHDA- 2011/12/08 06:01
CRDT- 2011/12/08 06:00
PHST- 2011/03/25 00:00 [received]
PHST- 2011/05/18 00:00 [accepted]
PHST- 2011/12/08 06:00 [entrez]
PHST- 2011/12/08 06:00 [pubmed]
PHST- 2011/12/08 06:01 [medline]
AID - 2045-9912-1-9 [pii]
AID - 10.1186/2045-9912-1-9 [doi]
PST - epublish
SO  - Med Gas Res. 2011 May 18;1(1):9. doi: 10.1186/2045-9912-1-9.


PMID- 22146336
OWN - NLM
STAT- MEDLINE
DCOM- 20120419
LR  - 20151119
IS  - 0300-8495 (Print)
IS  - 0300-8495 (Linking)
VI  - 40
IP  - 12
DP  - 2011 Dec
TI  - HoMER - an opportunity or threat to general practice research?
PG  - 1016-7
AB  - The National Health and Medical Research Council (NHMRC) Harmonisation of
      Multicentre Ethical Review (HoMER) project aims to implement a 'single ethical
      review', where the outcome of an ethical and scientific review by a single
      recognised Human Research Ethics Committee (HREC) will enable multiple
      institutions to decide whether or not to participate in a given study. The
      desired process will include agreement on time frames, authority of the reviewing
      HREC, respect among the jurisdictions, verification by independent organisations,
      and compliance with the national statement and relevant statutory and
      administrative frameworks. However, there appears to be little discourse on the
      implications for general practice research in the research community.
FAU - Liaw, Siaw-Teng
AU  - Liaw ST
AD  - University of New South Wales, New South Wales, Australia. siaw@unsw.edu.au
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Aust Fam Physician
JT  - Australian family physician
JID - 0326701
SB  - IM
MH  - Academies and Institutes/organization & administration
MH  - Attitude of Health Personnel
MH  - Australia
MH  - Ethical Review/*standards
MH  - Ethics Committees, Research/*standards
MH  - Ethics, Research
MH  - General Practice/ethics/*organization & administration
MH  - Humans
MH  - National Health Programs/organization & administration
MH  - Practice Patterns, Physicians'/ethics/*organization & administration
MH  - Primary Health Care/organization & administration
EDAT- 2011/12/08 06:00
MHDA- 2012/04/20 06:00
CRDT- 2011/12/08 06:00
PHST- 2011/12/08 06:00 [entrez]
PHST- 2011/12/08 06:00 [pubmed]
PHST- 2012/04/20 06:00 [medline]
PST - ppublish
SO  - Aust Fam Physician. 2011 Dec;40(12):1016-7.


PMID- 22146329
OWN - NLM
STAT- MEDLINE
DCOM- 20120419
LR  - 20111207
IS  - 0300-8495 (Print)
IS  - 0300-8495 (Linking)
VI  - 40
IP  - 12
DP  - 2011 Dec
TI  - Teaching medical students - ethical challenges.
PG  - 992-5
AB  - AIM: To explore ethical challenges for general practitioners teaching medical
      students in urban general practice. Methods Semistructured face-to-face
      interviews with 60 urban general practice teachers with diverse teaching loads
      and practice demographics. Interview data were analysed following member checking
      of interview records. RESULTS: Participants identified concerns in relation to a 
      number of areas including: student assessment and professionalism; teaching
      support from colleagues; patient consent and confidentiality; and the effects of 
      teaching on consultation dynamics, patient satisfaction and patient care.
      Participants with smaller teaching loads and with full fee-paying patients were
      more likely to express concerns about involving students actively in
      consultations. DISCUSSION: General practice teachers should consider modelling
      seeking informed patient consent in difficult circumstances, while being mindful 
      that patients may be reluctant to refuse or withdraw consent. Arguably students
      themselves should seek consent. General practitioners should consider maintaining
      the confidentiality of previously divulged patient information. Concerns about
      active student involvement in teaching consultations should be discussed with
      teaching colleagues from similar practice demographics, with reference to
      pertinent literature about patient attitudes to teaching.
FAU - Sturman, Nancy
AU  - Sturman N
AD  - Discipline of General Practice, The University of Queensland, Brisbane,
      Queensland, Australia. n.sturman1@uq.edu.au
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Aust Fam Physician
JT  - Australian family physician
JID - 0326701
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Education, Medical, Undergraduate/*ethics/methods
MH  - Family Practice/*education
MH  - Female
MH  - General Practitioners/*ethics/organization & administration
MH  - Humans
MH  - Interprofessional Relations/*ethics
MH  - Male
MH  - Middle Aged
MH  - Morals
MH  - Professional Competence
MH  - Queensland
MH  - Students, Medical
EDAT- 2011/12/08 06:00
MHDA- 2012/04/20 06:00
CRDT- 2011/12/08 06:00
PHST- 2011/12/08 06:00 [entrez]
PHST- 2011/12/08 06:00 [pubmed]
PHST- 2012/04/20 06:00 [medline]
PST - ppublish
SO  - Aust Fam Physician. 2011 Dec;40(12):992-5.


PMID- 22146039
OWN - NLM
STAT- MEDLINE
DCOM- 20120216
LR  - 20181201
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 11
IP  - 12
DP  - 2011 Dec
TI  - Polemics and pregnancy: a response to arguments about ethical obstetrical care.
PG  - 64-5
LID - 10.1080/15265161.2011.613523 [doi]
FAU - Bradbury-Jones, Caroline
AU  - Bradbury-Jones C
AD  - University of Dundee, UK. c.bradburyjones@dundee.ac.uk
FAU - Lee, Elaine
AU  - Lee E
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2011 Dec;11(12):51-6. PMID: 22146035
MH  - *Alcohol Drinking
MH  - Cesarean Section/*legislation & jurisprudence
MH  - *Coercion
MH  - Female
MH  - Humans
MH  - *Judicial Role
MH  - Male
MH  - Obstetrics/*standards
MH  - *Personal Autonomy
MH  - *Physician's Role
MH  - Pregnancy
MH  - *Prejudice
MH  - *Violence
MH  - *Women
EDAT- 2011/12/08 06:00
MHDA- 2012/02/18 06:00
CRDT- 2011/12/08 06:00
PHST- 2011/12/08 06:00 [entrez]
PHST- 2011/12/08 06:00 [pubmed]
PHST- 2012/02/18 06:00 [medline]
AID - 10.1080/15265161.2011.613523 [doi]
PST - ppublish
SO  - Am J Bioeth. 2011 Dec;11(12):64-5. doi: 10.1080/15265161.2011.613523.


PMID- 22146029
OWN - NLM
STAT- MEDLINE
DCOM- 20120216
LR  - 20111207
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 11
IP  - 12
DP  - 2011 Dec
TI  - Problems with prioritization: exploring ethical solutions to inequalities in HIV 
      care.
PG  - 32-40
LID - 10.1080/15265161.2011.627287 [doi]
AB  - Enormous gaps between HIV burden and health care availability in low-income
      countries raise severe ethical problems. This article analyzes four HIV-priority 
      dilemmas with interest across contexts and health systems. We explore principled 
      distributive conflicts and use the Atkinson index to make explicit trade-offs
      between health maximization and equality in health. We find that societies need a
      relatively low aversion to inequality to favor treatment for children, even with 
      large weights assigned to extending the lives of adults: higher inequality
      aversion is needed to share resources equally between high-cost and low-cost
      treatment; higher inequality aversion is needed to favor treatment rather than
      prevention, and the highest inequality aversion is needed to favor sharing
      treatment between urban and rural regions rather than urban provision of
      treatment. This type of ethical sensitivity analysis may clarify the ethics of
      health policy choice.
FAU - Johansson, Kjell Arne
AU  - Johansson KA
AD  - University of Bergen, Norway. kjell.johansson@isf.uib.no
FAU - Norheim, Ole Frithjof
AU  - Norheim OF
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
RN  - 0 (Anti-HIV Agents)
SB  - IM
CIN - Am J Bioeth. 2011 Dec;11(12):41-2. PMID: 22146030
CIN - Am J Bioeth. 2011 Dec;11(12):42-4. PMID: 22146031
CIN - Am J Bioeth. 2011 Dec;11(12):44-6. PMID: 22146032
CIN - Am J Bioeth. 2011 Dec;11(12):46-7. PMID: 22146033
CIN - Am J Bioeth. 2011 Dec;11(12):48-50. PMID: 22146034
MH  - Adult
MH  - Anti-HIV Agents/therapeutic use
MH  - *Antiretroviral Therapy, Highly Active/economics/ethics
MH  - Child
MH  - Choice Behavior/ethics
MH  - Decision Making/*ethics
MH  - *Developing Countries/economics
MH  - Ethical Analysis
MH  - *HIV Infections/drug therapy/prevention & control
MH  - Health Care Costs/ethics
MH  - Health Care Rationing/economics/*ethics
MH  - *Health Policy/trends
MH  - Health Priorities/economics/*ethics
MH  - Health Services Accessibility/*ethics/standards/trends
MH  - Humans
MH  - Mathematical Computing
MH  - Primary Prevention/economics/ethics
MH  - Rural Population
MH  - Tanzania
MH  - Urban Population
EDAT- 2011/12/08 06:00
MHDA- 2012/02/18 06:00
CRDT- 2011/12/08 06:00
PHST- 2011/12/08 06:00 [entrez]
PHST- 2011/12/08 06:00 [pubmed]
PHST- 2012/02/18 06:00 [medline]
AID - 10.1080/15265161.2011.627287 [doi]
PST - ppublish
SO  - Am J Bioeth. 2011 Dec;11(12):32-40. doi: 10.1080/15265161.2011.627287.


PMID- 22146026
OWN - NLM
STAT- MEDLINE
DCOM- 20120216
LR  - 20181201
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 11
IP  - 12
DP  - 2011 Dec
TI  - Good ethics begins with sound medicine: prostate cancer screening and
      chemoprevention.
PG  - 26-7
LID - 10.1080/15265161.2011.568583 [doi]
FAU - Ennis, Ronald
AU  - Ennis R
AD  - St. Luke's-Roosevelt Hospital Center, USA.
FAU - Jotkowitz, Alan
AU  - Jotkowitz A
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Biomarkers, Tumor)
RN  - EC 3.4.21.77 (Prostate-Specific Antigen)
SB  - IM
CON - Am J Bioeth. 2011 Dec;11(12):21-5. PMID: 22146025
MH  - Antineoplastic Agents/*therapeutic use
MH  - Biomarkers, Tumor/*blood
MH  - *Early Detection of Cancer
MH  - Humans
MH  - Male
MH  - Prostate-Specific Antigen/*blood
MH  - Prostatic Neoplasms/*prevention & control
EDAT- 2011/12/08 06:00
MHDA- 2012/02/18 06:00
CRDT- 2011/12/08 06:00
PHST- 2011/12/08 06:00 [entrez]
PHST- 2011/12/08 06:00 [pubmed]
PHST- 2012/02/18 06:00 [medline]
AID - 10.1080/15265161.2011.568583 [doi]
PST - ppublish
SO  - Am J Bioeth. 2011 Dec;11(12):26-7. doi: 10.1080/15265161.2011.568583.


PMID- 22145759
OWN - NLM
STAT- MEDLINE
DCOM- 20120406
LR  - 20151119
IS  - 1526-4637 (Electronic)
IS  - 1526-2375 (Linking)
VI  - 12
IP  - 12
DP  - 2011 Dec
TI  - The medical-industrial complex, professional medical associations, and continuing
      medical education.
PG  - 1713-9
LID - 10.1111/j.1526-4637.2011.01282.x [doi]
AB  - Financial relationships among the biomedical industries, physicians, and
      professional medical associations (PMAs) can be professional, ethical, mutually
      beneficial, and, most importantly, can lead to improved medical care. However,
      such relationships, by their very nature, present conflicts of interest (COIs).
      One of the greatest concerns regarding COI is continuing medical education (CME),
      especially because currently industry funds 40-60% of CME. COIs have the
      potential to bias physicians in practice, educators, and those in leadership
      positions of PMAs and well as the staff of a PMA. These conflicts lead to the
      potential to bias the content and type of CME presentations and thereby influence
      physicians' practice patterns and patient care. Physicians are generally aware of
      the potential for bias when industry contributes funding for CME, but they are
      most often unable to detect the bias. This may because it is very subtle and/or
      the educators themselves may not realize that they have been influenced by their 
      relationships with industry. Following Accreditation Council for Continuing
      Medical Education guidelines and mandating disclosure that is transparent and
      complete have become the fallback positions to manage COIs, but such disclosure
      does not really mitigate the conflict. The eventual and best solutions to ensure 
      evidence-based education are complete divestment by educators and leaders of
      PMAs, minimal and highly controlled industry funding of PMAs, blind pooling of
      any industry contributions to PMAs and CME, strict verification of disclosures,
      clear separation of marketing from education at CME events, and strict oversight 
      of presentations for the presence of bias.
CI  - Wiley Periodicals, Inc.
FAU - Schofferman, Jerome
AU  - Schofferman J
AD  - SpineCare Medical Group, San Francisco Spine Institute, Daly City and San
      Francisco, California, USA.
LA  - eng
PT  - Journal Article
DEP - 20111206
PL  - England
TA  - Pain Med
JT  - Pain medicine (Malden, Mass.)
JID - 100894201
SB  - IM
CIN - Pain Med. 2011 Dec;12(12):1710-2. PMID: 22168303
MH  - *Association
MH  - Conflict of Interest
MH  - Drug Industry/economics/*ethics
MH  - Education, Medical, Continuing/*economics/*ethics
MH  - Humans
MH  - Industry/economics/*ethics
MH  - Physicians/*ethics
MH  - Practice Patterns, Physicians'/ethics
EDAT- 2011/12/08 06:00
MHDA- 2012/04/07 06:00
CRDT- 2011/12/08 06:00
PHST- 2011/12/08 06:00 [entrez]
PHST- 2011/12/08 06:00 [pubmed]
PHST- 2012/04/07 06:00 [medline]
AID - 10.1111/j.1526-4637.2011.01282.x [doi]
PST - ppublish
SO  - Pain Med. 2011 Dec;12(12):1713-9. doi: 10.1111/j.1526-4637.2011.01282.x. Epub
      2011 Dec 6.


PMID- 22145723
OWN - NLM
STAT- MEDLINE
DCOM- 20120403
LR  - 20191210
IS  - 1545-5300 (Electronic)
IS  - 0014-7370 (Linking)
VI  - 50
IP  - 4
DP  - 2011 Dec
TI  - A socio-emotional relational framework for infidelity: the relational justice
      approach.
PG  - 516-28
LID - 10.1111/j.1545-5300.2011.01374.x [doi]
AB  - Current clinical models for addressing infidelity tend not to make social context
      issues a central focus; yet, societal gender and power structures, such as female
      responsibility for relationships and limited male vulnerability, affect the
      etiology of affairs and create power imbalances in intimate relationships. How
      therapists respond to these societal influences may either limit or enhance the
      mutual healing of both persons in the relationship. Thus attention to these
      societal processes is an ethical issue. This paper presents one perspective, the 
      Relational Justice Approach, for working with infidelity. It places gender,
      power, and culture at the center of intervention in couple therapy, and includes 
      three stages: (1) creating an equitable foundation for healing, (2) placing the
      infidelity in a societal context, and (3) practicing mutuality. Each stage is
      illustrated with case examples and contrasted with current practice regarding
      infidelity.
FAU - Williams, Kirstee
AU  - Williams K
AD  - Loma Linda University, USA. khurt@llu.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Fam Process
JT  - Family process
JID - 0400666
SB  - IM
MH  - *Couples Therapy
MH  - Culture
MH  - Female
MH  - Humans
MH  - Internal-External Control
MH  - Interpersonal Relations
MH  - Male
MH  - Power, Psychological
MH  - *Sexual Behavior
MH  - *Social Justice
EDAT- 2011/12/08 06:00
MHDA- 2012/04/04 06:00
CRDT- 2011/12/08 06:00
PHST- 2011/12/08 06:00 [entrez]
PHST- 2011/12/08 06:00 [pubmed]
PHST- 2012/04/04 06:00 [medline]
AID - 10.1111/j.1545-5300.2011.01374.x [doi]
PST - ppublish
SO  - Fam Process. 2011 Dec;50(4):516-28. doi: 10.1111/j.1545-5300.2011.01374.x.


PMID- 22145607
OWN - NLM
STAT- MEDLINE
DCOM- 20120529
LR  - 20141120
IS  - 1557-9034 (Electronic)
IS  - 1092-6429 (Linking)
VI  - 22
IP  - 1
DP  - 2012 Jan-Feb
TI  - Mapping the maze of minimally invasive surgery simulators.
PG  - 51-60
LID - 10.1089/lap.2010.0467 [doi]
AB  - BACKGROUND: Conforming to, among other considerations, legal and ethical concerns
      for patient safety, there is an increasing demand to assess a surgeon's skills
      prior to performance in the operating room in pursuit of higher-quality
      treatment. Training in minimally invasive surgery (MIS) must therefore be
      intensified, including team training. New methods to train and assess minimally
      invasive surgical skills are gaining interest. The goal of this review is to
      provide instructors with an overview of available MIS training tools. In this
      review, we discuss currently available simulators for MIS training.
      Applicability, validity, and construction of simulators are reviewed. Also, some 
      of the leading training programs and assessment methods in MIS are reviewed.
      METHODS: A literature search was performed on studies evaluating surgical task
      performance on a simulator, reviewing satisfaction with laparoscopic training
      programs, or validating simulators or assessment methods. RESULTS: Simulators may
      be divided into simple box trainers and computer-based systems, such as virtual
      and augmented simulators. All have advantages and disadvantages. An overview is
      provided of currently available training systems, validity, trainee assessment,
      and the importance of training programs in MIS. CONCLUSIONS: No simulator yet
      provides the ability to train the entire set of required psychomotor skills or
      procedures for MIS. A multiyear training program combining various simulators for
      multiple-level training, including team training, should be constructed.
FAU - van Empel, Pieter J
AU  - van Empel PJ
AD  - Department of Surgery, VU University Medical Centre, Amsterdam, The Netherlands. 
      p.vanempel@vumc.nl
FAU - van der Veer, Willem M
AU  - van der Veer WM
FAU - van Rijssen, Lennart B
AU  - van Rijssen LB
FAU - Cuesta, Miguel A
AU  - Cuesta MA
FAU - Scheele, Fedde
AU  - Scheele F
FAU - Bonjer, H Jaap
AU  - Bonjer HJ
FAU - Meijerink, Wilhelmus J
AU  - Meijerink WJ
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111206
PL  - United States
TA  - J Laparoendosc Adv Surg Tech A
JT  - Journal of laparoendoscopic & advanced surgical techniques. Part A
JID - 9706293
SB  - IM
MH  - Clinical Competence
MH  - *Computer Simulation
MH  - Humans
MH  - Learning Curve
MH  - Minimally Invasive Surgical Procedures/*education
MH  - Psychoneuroimmunology
MH  - Task Performance and Analysis
MH  - User-Computer Interface
EDAT- 2011/12/08 06:00
MHDA- 2012/05/30 06:00
CRDT- 2011/12/08 06:00
PHST- 2011/12/08 06:00 [entrez]
PHST- 2011/12/08 06:00 [pubmed]
PHST- 2012/05/30 06:00 [medline]
AID - 10.1089/lap.2010.0467 [doi]
PST - ppublish
SO  - J Laparoendosc Adv Surg Tech A. 2012 Jan-Feb;22(1):51-60. doi:
      10.1089/lap.2010.0467. Epub 2011 Dec 6.


PMID- 22145430
OWN - NLM
STAT- MEDLINE
DCOM- 20120207
LR  - 20191210
IS  - 0038-0814 (Print)
IS  - 0038-0814 (Linking)
IP  - 759
DP  - 2011 Oct
TI  - [The place of ethics in patient empowerment].
PG  - 21-3
AB  - Therapeutic education teaches patients how to understand, grasp and take personal
      charge of their pathology. This freedom of choice and action can cause patients
      to feel guilty, especially if their condition worsens. How should this form of
      empowerment be managed, by the caregiver as well as the patient? Questioning of
      an ethical nature is therefore necessary.
FAU - Hobik, Laurence
AU  - Hobik L
AD  - Centre hospitalier de Macon. laurence.hobik@orange.fr
LA  - fre
PT  - Case Reports
PT  - Journal Article
TT  - La place de l'ethique dans la responsabilisation du patient.
PL  - France
TA  - Soins
JT  - Soins; la revue de reference infirmiere
JID - 20910580R
MH  - Adult
MH  - Disease Progression
MH  - *Ethics, Nursing
MH  - Female
MH  - France
MH  - Guilt
MH  - Health Behavior
MH  - Heart Failure/nursing
MH  - Hospitalization
MH  - Humans
MH  - Life Style
MH  - Nurse-Patient Relations/*ethics
MH  - Patient Education as Topic/*ethics
MH  - Patient Participation
MH  - Personal Autonomy
MH  - *Power, Psychological
EDAT- 2011/12/08 06:00
MHDA- 2012/02/09 06:00
CRDT- 2011/12/08 06:00
PHST- 2011/12/08 06:00 [entrez]
PHST- 2011/12/08 06:00 [pubmed]
PHST- 2012/02/09 06:00 [medline]
PST - ppublish
SO  - Soins. 2011 Oct;(759):21-3.


PMID- 22145376
OWN - NLM
STAT- MEDLINE
DCOM- 20120125
LR  - 20161020
IS  - 0869-6047 (Print)
IS  - 0869-6047 (Linking)
IP  - 9
DP  - 2011
TI  - [Ethical problems of mutagenesis and genetic testing at the workplace].
PG  - 68-72
AB  - Selected ethical problems arising in the studies of mutagenic effects and genetic
      testing at the workplace (genetic monitoring and genetic screening) are
      discussed.
FAU - Izhevskaia, V L
AU  - Izhevskaia VL
LA  - rus
PT  - English Abstract
PT  - Journal Article
PL  - Russia (Federation)
TA  - Vestn Ross Akad Med Nauk
JT  - Vestnik Rossiiskoi akademii meditsinskikh nauk
JID - 9215641
SB  - IM
MH  - Environmental Monitoring/methods
MH  - Genetic Privacy/*ethics
MH  - *Genetic Testing/ethics/standards
MH  - Humans
MH  - Mass Screening/ethics/organization & administration
MH  - *Mutagenesis
MH  - Mutagenicity Tests
MH  - *Occupational Diseases/diagnosis/genetics/prevention & control
MH  - Occupational Exposure/adverse effects/*prevention & control
MH  - Occupational Health Services/ethics/*organization & administration
MH  - Risk Management
MH  - Risk Reduction Behavior
MH  - Workplace/psychology/standards
EDAT- 2011/12/08 06:00
MHDA- 2012/01/26 06:00
CRDT- 2011/12/08 06:00
PHST- 2011/12/08 06:00 [entrez]
PHST- 2011/12/08 06:00 [pubmed]
PHST- 2012/01/26 06:00 [medline]
PST - ppublish
SO  - Vestn Ross Akad Med Nauk. 2011;(9):68-72.


PMID- 22145369
OWN - NLM
STAT- MEDLINE
DCOM- 20120125
LR  - 20161020
IS  - 0869-6047 (Print)
IS  - 0869-6047 (Linking)
IP  - 9
DP  - 2011
TI  - [Personalized medicine: expectations, disappointments and hopes].
PG  - 27-35
AB  - Impressive advances in the studies of human genome, identification of mutant
      genes of hereditary diseases and candidate genes of many chronic multifactorial
      diseases (MFD) laid the foundation of molecular medicine. Its characteristic
      features, such as the focus on individual prophylactic care, give reason to
      consider it as personalized predictive medicine (PPM). The fundamental concept
      behind PPM comprises the notion of genetic passport and its methodological basis 
      is genetic testing (GT). Recent progress in PPM has been achieved due to the
      introduction of comprehensive genomic screening of associations. At the same
      time, the contribution of known individual genes to the development of MFD
      appears to be relatively insignificant which does not allow to identify the main 
      causes of MFD. It gave rise to some scepsis as regards the value of genome as a
      source of information for practical medicine. Possibilities for the improvement
      of GT and conditions for the introduction of the available data into clinical
      practice are discussed. The necessity to attract clinicians to the work on PPM is
      emphasized. The development of unified MFD gene panels for clinical application
      and software for the evaluation and interpretation of GT results for doctors and 
      patients is an indispensable condition for the use of PPM knowledge in the
      healthcare practice. The importance of solution of relevant ethical, juridical,
      and social issues is underscored.
FAU - Baranov, V S
AU  - Baranov VS
LA  - rus
PT  - English Abstract
PT  - Journal Article
PL  - Russia (Federation)
TA  - Vestn Ross Akad Med Nauk
JT  - Vestnik Rossiiskoi akademii meditsinskikh nauk
JID - 9215641
SB  - IM
MH  - *Genetic Predisposition to Disease
MH  - Genetic Privacy/ethics
MH  - Genetic Services/ethics/*standards/trends
MH  - Genetic Testing/ethics/*standards/trends
MH  - Genome, Human
MH  - Humans
MH  - Multifactorial Inheritance/*genetics
MH  - Pedigree
MH  - *Precision Medicine/ethics/standards/trends
MH  - Quality Improvement
EDAT- 2011/12/08 06:00
MHDA- 2012/01/26 06:00
CRDT- 2011/12/08 06:00
PHST- 2011/12/08 06:00 [entrez]
PHST- 2011/12/08 06:00 [pubmed]
PHST- 2012/01/26 06:00 [medline]
PST - ppublish
SO  - Vestn Ross Akad Med Nauk. 2011;(9):27-35.


PMID- 22145253
OWN - NLM
STAT- MEDLINE
DCOM- 20111222
LR  - 20181201
IS  - 0001-5164 (Print)
IS  - 0001-5164 (Linking)
VI  - 62
IP  - 3
DP  - 2011
TI  - Ethics in clinical studies, with special reference to obstetric practice.
PG  - 131-2
FAU - Vercauteren, M
AU  - Vercauteren M
LA  - eng
PT  - Editorial
PT  - Comment
PL  - Belgium
TA  - Acta Anaesthesiol Belg
JT  - Acta anaesthesiologica Belgica
JID - 0421022
RN  - 7S5I7G3JQL (Dexamethasone)
SB  - IM
CON - Acta Anaesthesiol Belg. 2011;62(3):143-6. PMID: 22145255
MH  - Anesthesia, Spinal/*adverse effects
MH  - Dexamethasone/*therapeutic use
MH  - Female
MH  - Humans
MH  - Male
MH  - Post-Dural Puncture Headache/*prevention & control
EDAT- 2011/12/08 06:00
MHDA- 2011/12/23 06:00
CRDT- 2011/12/08 06:00
PHST- 2011/12/08 06:00 [entrez]
PHST- 2011/12/08 06:00 [pubmed]
PHST- 2011/12/23 06:00 [medline]
PST - ppublish
SO  - Acta Anaesthesiol Belg. 2011;62(3):131-2.


PMID- 22145155
OWN - HMD
STAT- MEDLINE
DCOM- 20121002
LR  - 20191112
IS  - 0002-7294 (Print)
IS  - 0002-7294 (Linking)
VI  - 113
IP  - 3
DP  - 2011
TI  - Who has time for Cejf? Postsocialist migration and slow coffee in neoliberal
      Chicago.
PG  - 463-77
AB  - The official end to communism in Eastern Europe marked the onset of major
      migratory movements. Perhaps the most abrupt of these population shifts was the
      displacement of more than two million people in Yugoslavia's violent dissolution.
      Much of the existing literature on refugee migration has focused on victimization
      and citizenship claims. Alternatively, I draw on ethnographic research among
      Bosnian refugee-immigrants in Chicago to examine how a group of adult women
      migrants used one commodity - coffee - to manage and evaluate their
      displacements. The kind of slow-coffee drinking described here is informed by an 
      ethics of consumption developed under Yugoslav socialism, nostalgias for
      pre-Yugoslav Islam and pre-Ottoman Bosnia, and exposure to U.S. neoliberalism.
      Placing consumption at the center of analysis reveals the structural constraints 
      of the postconflict period and brings to light refugees' active navigations of
      everyday life and society in their postsocialist present, lived out as refugees
      in the United States.
FAU - Croegaert, Ana
AU  - Croegaert A
AD  - Loyola University, Chicago.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - Am Anthropol
JT  - American anthropologist
JID - 1275273
MH  - *Acculturation/history
MH  - *Activities of Daily Living/psychology
MH  - Chicago/ethnology
MH  - *Emigrants and Immigrants/education/history/legislation &
      jurisprudence/psychology
MH  - Europe, Eastern/ethnology
MH  - History, 20th Century
MH  - History, 21st Century
MH  - *Population Dynamics/history
MH  - Refugees/education/history/legislation & jurisprudence/psychology
MH  - *Social Behavior/history
MH  - Socialization
MH  - Transients and Migrants/education/history/legislation & jurisprudence/psychology
EDAT- 2011/12/07 06:00
MHDA- 2012/10/04 06:00
CRDT- 2011/12/07 06:00
PHST- 2011/12/07 06:00 [entrez]
PHST- 2011/12/07 06:00 [pubmed]
PHST- 2012/10/04 06:00 [medline]
AID - 10.1111/j.1548-1433.2011.01354.x [doi]
PST - ppublish
SO  - Am Anthropol. 2011;113(3):463-77. doi: 10.1111/j.1548-1433.2011.01354.x.


PMID- 22144705
OWN - NLM
STAT- MEDLINE
DCOM- 20120214
LR  - 20211203
IS  - 1098-4275 (Electronic)
IS  - 0031-4005 (Linking)
VI  - 129
IP  - 1
DP  - 2012 Jan
TI  - Translational research in pediatrics: tissue sampling and biobanking.
PG  - 153-62
LID - 10.1542/peds.2011-0134 [doi]
AB  - Translational research is expanding and has become a focus of National Research
      funding agencies, touted as the primary avenue to improve health care practice.
      The use of human tissues for research on disease etiology is a pillar of
      translational research, particularly with innovations in research technologies to
      investigate the building blocks of disease. In pediatrics, translational research
      using human tissues has been hindered by the many practical and ethical
      considerations associated with tissue procurement from children and also by a
      limited population base for study, by the increasing complexities in conducting
      clinical research, and by a lack of dedicated child-health research funding.
      Given these obstacles, pediatric translational research can be enhanced by
      developing strategic and efficient biobanks that will provide scientists with
      quality tissue specimens to render accurate and reproducible research results.
      Indeed, tissue sampling and biobanking within pediatric academic settings has
      potential to impact child health by promoting bidirectional interaction between
      clinicians and scientists, helping to maximize research productivity, and
      providing a competitive edge for attracting and maintaining high-quality
      personnel. The authors of this review outline key issues and practical solutions 
      to optimize pediatric tissue sampling and biobanking for translational research, 
      activities that will ultimately reduce the burden of childhood disease.
FAU - Brisson, Alayne R
AU  - Brisson AR
AD  - Translational Research Centre, London, Ontario, Canada.
FAU - Matsui, Doreen
AU  - Matsui D
FAU - Rieder, Michael J
AU  - Rieder MJ
FAU - Fraser, Douglas D
AU  - Fraser DD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20111205
PL  - United States
TA  - Pediatrics
JT  - Pediatrics
JID - 0376422
SB  - IM
MH  - *Biological Specimen Banks/economics/organization & administration/standards
MH  - Child
MH  - Humans
MH  - *Pediatrics
MH  - *Specimen Handling/standards
MH  - *Translational Research, Biomedical
EDAT- 2011/12/07 06:00
MHDA- 2012/02/15 06:00
CRDT- 2011/12/07 06:00
PHST- 2011/12/07 06:00 [entrez]
PHST- 2011/12/07 06:00 [pubmed]
PHST- 2012/02/15 06:00 [medline]
AID - peds.2011-0134 [pii]
AID - 10.1542/peds.2011-0134 [doi]
PST - ppublish
SO  - Pediatrics. 2012 Jan;129(1):153-62. doi: 10.1542/peds.2011-0134. Epub 2011 Dec 5.


PMID- 22144085
OWN - NLM
STAT- MEDLINE
DCOM- 20120807
LR  - 20111206
IS  - 1098-9056 (Electronic)
IS  - 0734-0478 (Linking)
VI  - 32
IP  - 4
DP  - 2011 Nov
TI  - Ethical issues in a pediatric private practice.
PG  - 347-56
LID - 10.1055/s-0031-1292760 [doi]
AB  - Building a successful pediatric private practice requires clinical expertise and 
      an understanding of the business process, as well as familiarity with the
      American Speech-Language-Hearing Association Code of Ethics. This article
      provides an overview of the ethical issues that may be encountered when building 
      a practice, including a look at marketing and advertising, financial management, 
      privacy, and documentation. Ethically sound decision making is a key to a
      successful business.
CI  - (c) Thieme Medical Publishers.
FAU - Jakubowitz, Melissa
AU  - Jakubowitz M
AD  - Presence Learning, San Francisco, California, USA. lthpfxr@gmail.com
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111205
PL  - United States
TA  - Semin Speech Lang
JT  - Seminars in speech and language
JID - 8405117
SB  - IM
MH  - American Speech-Language-Hearing Association
MH  - Child
MH  - Decision Making/ethics
MH  - *Ethics, Medical
MH  - Humans
MH  - Pediatrics/*ethics
MH  - Private Practice/ethics
MH  - United States
EDAT- 2011/12/07 06:00
MHDA- 2012/08/08 06:00
CRDT- 2011/12/07 06:00
PHST- 2011/12/07 06:00 [entrez]
PHST- 2011/12/07 06:00 [pubmed]
PHST- 2012/08/08 06:00 [medline]
AID - 10.1055/s-0031-1292760 [doi]
PST - ppublish
SO  - Semin Speech Lang. 2011 Nov;32(4):347-56. doi: 10.1055/s-0031-1292760. Epub 2011 
      Dec 5.


PMID- 22144084
OWN - NLM
STAT- MEDLINE
DCOM- 20120807
LR  - 20111206
IS  - 1098-9056 (Electronic)
IS  - 0734-0478 (Linking)
VI  - 32
IP  - 4
DP  - 2011 Nov
TI  - Ethical issues in the conduct of research at a multidisciplinary clinic.
PG  - 338-46
LID - 10.1055/s-0031-1292759 [doi]
AB  - We describe the process our interdisciplinary clinic used to create an
      institutional policy regarding research participant recruitment from among our
      client base. We demonstrate how certain elements of the client-clinician
      relationship can lead to inadvertent ethical quandaries in research recruitment, 
      including implicit coercion and fostering of "therapeutic misconception." Our
      internal policy deliberations focused on five central dilemmas, each requiring a 
      careful evaluation of ethical principles. Interpersonal and cross-disciplinary
      differences of opinion required a delicate balance among competing priorities.
      The final policy represents our attempt to resolve these ethical paradoxes in a
      way that allows us to support and pursue valuable clinician-researcher
      partnerships while prioritizing both our clients' clinical care and their rights 
      to autonomy and fully informed consent.
CI  - (c) Thieme Medical Publishers.
FAU - Larsen, Jennifer
AU  - Larsen J
AD  - Speech-Language Pathology Services, Artz Center for Developmental Health and
      Audiology, Portland, Oregon, USA. jennyl@artzcenter.org
FAU - McMillin, Andy
AU  - McMillin A
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111205
PL  - United States
TA  - Semin Speech Lang
JT  - Seminars in speech and language
JID - 8405117
SB  - IM
MH  - Ethics, Clinical
MH  - *Ethics, Research
MH  - Humans
MH  - Patient Selection/*ethics
MH  - Physician-Patient Relations/*ethics
MH  - Therapeutic Misconception/ethics
EDAT- 2011/12/07 06:00
MHDA- 2012/08/08 06:00
CRDT- 2011/12/07 06:00
PHST- 2011/12/07 06:00 [entrez]
PHST- 2011/12/07 06:00 [pubmed]
PHST- 2012/08/08 06:00 [medline]
AID - 10.1055/s-0031-1292759 [doi]
PST - ppublish
SO  - Semin Speech Lang. 2011 Nov;32(4):338-46. doi: 10.1055/s-0031-1292759. Epub 2011 
      Dec 5.


PMID- 22144083
OWN - NLM
STAT- MEDLINE
DCOM- 20120807
LR  - 20111206
IS  - 1098-9056 (Electronic)
IS  - 0734-0478 (Linking)
VI  - 32
IP  - 4
DP  - 2011 Nov
TI  - Ethics in the practice of speech-language pathology in health care settings.
PG  - 330-7
LID - 10.1055/s-0031-1292758 [doi]
AB  - ETHICS refers to a moral philosophy or a set of moral principles that determine
      appropriate behavior in a society. Medical ethics includes a set of specific
      values that are considered in determining appropriate conduct in the practice of 
      medicine or health care. Because the practice of medicine and medical
      speech-language pathology affects the health, well-being, and quality of life of 
      individuals served, adherence to a code of ethical conduct is critically
      important in the health care environment. When ethical dilemmas arise,
      consultation with a bioethics committee can be helpful in determining the best
      course of action. This article will help to define medical ethics and to discuss 
      the six basic values that are commonly considered in discussions of medical
      ethics. Common ethical mistakes in the practice of speech-language pathology will
      be described. Finally, the value of a bioethics consultation for help in
      resolving complex ethical issues will be discussed.
CI  - (c) Thieme Medical Publishers.
FAU - Kummer, Ann W
AU  - Kummer AW
AD  - Division of Speech Pathology, Cincinnati Children's Hospital Medical Center,
      Cincinnati, Ohio 45229-3039, USA. ann.kummer@cchmc.org
FAU - Turner, Jan
AU  - Turner J
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111205
PL  - United States
TA  - Semin Speech Lang
JT  - Seminars in speech and language
JID - 8405117
SB  - IM
MH  - Bioethics
MH  - *Ethics, Clinical
MH  - Humans
MH  - Personal Autonomy
MH  - Speech-Language Pathology/*ethics
EDAT- 2011/12/07 06:00
MHDA- 2012/08/08 06:00
CRDT- 2011/12/07 06:00
PHST- 2011/12/07 06:00 [entrez]
PHST- 2011/12/07 06:00 [pubmed]
PHST- 2012/08/08 06:00 [medline]
AID - 10.1055/s-0031-1292758 [doi]
PST - ppublish
SO  - Semin Speech Lang. 2011 Nov;32(4):330-7. doi: 10.1055/s-0031-1292758. Epub 2011
      Dec 5.


PMID- 22144082
OWN - NLM
STAT- MEDLINE
DCOM- 20120807
LR  - 20111206
IS  - 1098-9056 (Electronic)
IS  - 0734-0478 (Linking)
VI  - 32
IP  - 4
DP  - 2011 Nov
TI  - Ethics in stuttering treatment in the schools: issues and intersections.
PG  - 319-29
LID - 10.1055/s-0031-1292757 [doi]
AB  - When the challenges of providing speech-language pathology services in school
      settings intersect with the complexities of meeting the unique needs of students 
      who stutter, clinicians may encounter a variety of ethical issues. This article
      explores some of the ethical challenges of treating stuttering in school settings
      by discussing three clinical scenarios. Seedhouse's Ethics Grid is provided as a 
      scaffold to support the critical analysis of school-based stuttering treatment
      issues. Factors examined include creating and respecting autonomy, serving
      student needs, doing good and minimizing risks, and telling the truth and keeping
      promises. In addition, clinical outcomes are considered in terms of their impact 
      on students and family members, clinicians, students with communication disorders
      other than stuttering, and school personnel. Finally, some of the practical
      concerns when treating stuttering in school settings are discussed, including the
      law, codes of practice, wishes of others, as well as the effectiveness and
      efficiency of actions.
CI  - (c) Thieme Medical Publishers.
FAU - Watson, Jennifer B
AU  - Watson JB
AD  - Miller Speech and Hearing Clinic, Texas Christian University, Fort Worth, Texas
      76129-0001, USA. j.watson@tcu.edu
FAU - Byrd, Courtney T
AU  - Byrd CT
FAU - Moore, Barbara J
AU  - Moore BJ
LA  - eng
PT  - Journal Article
DEP - 20111205
PL  - United States
TA  - Semin Speech Lang
JT  - Seminars in speech and language
JID - 8405117
SB  - IM
MH  - Humans
MH  - School Health Services/*ethics
MH  - Schools
MH  - Speech-Language Pathology/*ethics
MH  - Stuttering/*therapy
EDAT- 2011/12/07 06:00
MHDA- 2012/08/08 06:00
CRDT- 2011/12/07 06:00
PHST- 2011/12/07 06:00 [entrez]
PHST- 2011/12/07 06:00 [pubmed]
PHST- 2012/08/08 06:00 [medline]
AID - 10.1055/s-0031-1292757 [doi]
PST - ppublish
SO  - Semin Speech Lang. 2011 Nov;32(4):319-29. doi: 10.1055/s-0031-1292757. Epub 2011 
      Dec 5.


PMID- 22144081
OWN - NLM
STAT- MEDLINE
DCOM- 20120807
LR  - 20111206
IS  - 1098-9056 (Electronic)
IS  - 0734-0478 (Linking)
VI  - 32
IP  - 4
DP  - 2011 Nov
TI  - Good ethical tone in the work setting.
PG  - 309-18
LID - 10.1055/s-0031-1292756 [doi]
AB  - Speech-language pathologists report a broad range of situations that they believe
      represent professional dilemmas. Some arise in their employment settings because 
      of mandates and employment-related policies established by their employers,
      supervisors, and administrators. Their reports do not as often reflect the many
      instances where ethical problems associated with the workplace may occur because 
      of the conduct and actions of speech-language pathologists themselves. The
      purpose of this article is to identify and discuss some common quandaries
      speech-language pathologists and their employers may experience that are
      associated with workplace-related matters.
CI  - (c) Thieme Medical Publishers.
FAU - Denton, David R
AU  - Denton DR
AD  - American Speech and Language Association, Rockville, Maryland, USA.
      davrdenton@aol.com
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111205
PL  - United States
TA  - Semin Speech Lang
JT  - Seminars in speech and language
JID - 8405117
SB  - IM
MH  - *Ethics, Professional
MH  - Humans
MH  - Malpractice
MH  - Speech-Language Pathology/*ethics
MH  - Work/*ethics
EDAT- 2011/12/07 06:00
MHDA- 2012/08/08 06:00
CRDT- 2011/12/07 06:00
PHST- 2011/12/07 06:00 [entrez]
PHST- 2011/12/07 06:00 [pubmed]
PHST- 2012/08/08 06:00 [medline]
AID - 10.1055/s-0031-1292756 [doi]
PST - ppublish
SO  - Semin Speech Lang. 2011 Nov;32(4):309-18. doi: 10.1055/s-0031-1292756. Epub 2011 
      Dec 5.


PMID- 22144080
OWN - NLM
STAT- MEDLINE
DCOM- 20120807
LR  - 20111206
IS  - 1098-9056 (Electronic)
IS  - 0734-0478 (Linking)
VI  - 32
IP  - 4
DP  - 2011 Nov
TI  - Ethical deliberation: a foundation for evidence-based practice.
PG  - 298-308
LID - 10.1055/s-0031-1292755 [doi]
AB  - Infusing evidence-based practice (EBP) into the clinical setting implies that
      professionals use evidence that is relevant and credible, maintain their pursuit 
      of best current knowledge, respect their clients' preferences and values, and
      keep these clients and their families appropriately informed about their
      treatment options. Thus, rational and judicious EBP must be guided by
      speech-language pathologists' or audiologists' ethical principles of beneficence,
      non-maleficence, justice, and autonomy. In this article, we will affirm the
      centrality of ethical reasoning in EBP by describing what it means to be a
      professional as reflected in our Code of Ethics, reviewing the principles of
      ethics that underlie clinical decision making, and demonstrating how an ethical
      framework can and should provide the context in which EBP is conducted.
CI  - (c) Thieme Medical Publishers.
FAU - Chabon, Shelly
AU  - Chabon S
AD  - Department of Speech & Hearing Sciences, Portland State University, Portland,
      Oregon 97207, USA. chabonr@pdx.edu
FAU - Morris, John
AU  - Morris J
FAU - Lemoncello, Rik
AU  - Lemoncello R
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111205
PL  - United States
TA  - Semin Speech Lang
JT  - Seminars in speech and language
JID - 8405117
SB  - IM
MH  - *Codes of Ethics
MH  - Decision Making/*ethics
MH  - *Ethics, Professional
MH  - Ethics, Research
MH  - Evidence-Based Practice/*ethics
MH  - Humans
MH  - Personal Autonomy
MH  - Speech-Language Pathology/*ethics
MH  - United States
EDAT- 2011/12/07 06:00
MHDA- 2012/08/08 06:00
CRDT- 2011/12/07 06:00
PHST- 2011/12/07 06:00 [entrez]
PHST- 2011/12/07 06:00 [pubmed]
PHST- 2012/08/08 06:00 [medline]
AID - 10.1055/s-0031-1292755 [doi]
PST - ppublish
SO  - Semin Speech Lang. 2011 Nov;32(4):298-308. doi: 10.1055/s-0031-1292755. Epub 2011
      Dec 5.


PMID- 22144079
OWN - NLM
STAT- MEDLINE
DCOM- 20120807
LR  - 20111206
IS  - 1098-9056 (Electronic)
IS  - 0734-0478 (Linking)
VI  - 32
IP  - 4
DP  - 2011 Nov
TI  - Promoting ethical research practices: perspectives from pediatric populations.
PG  - 289-97
LID - 10.1055/s-0031-1292754 [doi]
AB  - Engaging in research activities can be an enriching aspect of one's professional 
      career. Research serves to advance the knowledge base from which clinical
      decisions are founded and is the responsibility of all who provide clinical
      services. That is, developing and advancing this knowledge base is everyone's
      responsibility, whether as consumers of research or as direct contributors of
      research. Understanding the ethical issues that embrace the research enterprise
      is a complementary responsibility of professionals. Conducting research within an
      ethical framework is essential to maintaining integrity and credibility in
      science. Opportunities to promote scientific integrity are particularly relevant 
      when conducting or examining research involving children. Therefore, the purpose 
      of this article is to provide an overview of the role of research in clinical
      practice, particularly in an environment with pediatric populations. The article 
      will unfold with three major themes: (1) understanding the value of research in
      the clinical environment, (2) describing factors that contribute to sound ethical
      practices, and (3) promoting integrity in research conducted with pediatric
      populations.
CI  - (c) Thieme Medical Publishers.
FAU - Moss, Sharon E
AU  - Moss SE
AD  - Office of Research Oversight, Department of Veteran Affairs, Washington, DC
      20420, USA. Sharon.moss2@va.gov
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111205
PL  - United States
TA  - Semin Speech Lang
JT  - Seminars in speech and language
JID - 8405117
SB  - IM
MH  - Child
MH  - *Codes of Ethics
MH  - *Ethics, Research
MH  - Humans
MH  - Pediatrics/*ethics
EDAT- 2011/12/07 06:00
MHDA- 2012/08/08 06:00
CRDT- 2011/12/07 06:00
PHST- 2011/12/07 06:00 [entrez]
PHST- 2011/12/07 06:00 [pubmed]
PHST- 2012/08/08 06:00 [medline]
AID - 10.1055/s-0031-1292754 [doi]
PST - ppublish
SO  - Semin Speech Lang. 2011 Nov;32(4):289-97. doi: 10.1055/s-0031-1292754. Epub 2011 
      Dec 5.


PMID- 22144078
OWN - NLM
STAT- MEDLINE
DCOM- 20120807
LR  - 20111206
IS  - 1098-9056 (Electronic)
IS  - 0734-0478 (Linking)
VI  - 32
IP  - 4
DP  - 2011 Nov
TI  - Ethics of disability: foundation of the profession of speech-language pathology.
PG  - 279-88
LID - 10.1055/s-0031-1292753 [doi]
AB  - Ethics is a continuous and dynamic decision process that ultimately seeks to
      render a judgment about the morality of human conduct. A genre of applied ethics,
      social ethics is concerned with promoting societal morality, specifically
      ensuring the rights of disenfranchised groups such as people with disabilities.
      This article will examine concepts of ethical theory and practice and also trace 
      the historical development and evolution of social ethics for disability. In its 
      conclusion, this article will highlight the advocacy role of speech and language 
      professionals to ensure an ethical response to disability.
CI  - (c) Thieme Medical Publishers.
FAU - Payne, Kay T
AU  - Payne KT
AD  - Department of Communication Sciences & Disorders, Howard University, Washington, 
      DC 20059, USA. kpayne@howard.edu
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111205
PL  - United States
TA  - Semin Speech Lang
JT  - Seminars in speech and language
JID - 8405117
SB  - IM
MH  - Decision Making/*ethics
MH  - *Disabled Persons
MH  - Humans
MH  - *Social Justice
MH  - Speech-Language Pathology/*ethics
EDAT- 2011/12/07 06:00
MHDA- 2012/08/08 06:00
CRDT- 2011/12/07 06:00
PHST- 2011/12/07 06:00 [entrez]
PHST- 2011/12/07 06:00 [pubmed]
PHST- 2012/08/08 06:00 [medline]
AID - 10.1055/s-0031-1292753 [doi]
PST - ppublish
SO  - Semin Speech Lang. 2011 Nov;32(4):279-88. doi: 10.1055/s-0031-1292753. Epub 2011 
      Dec 5.


PMID- 22144077
OWN - NLM
STAT- MEDLINE
DCOM- 20120807
LR  - 20111206
IS  - 1098-9056 (Electronic)
IS  - 0734-0478 (Linking)
VI  - 32
IP  - 4
DP  - 2011 Nov
TI  - Ethics at work: issues and insights across employment settings.
PG  - 277-8
LID - 10.1055/s-0031-1292752 [doi]
FAU - Chabon, Shelly
AU  - Chabon S
AD  - Department of Speech & Hearing Sciences, Portland State University, Portland,
      Oregon 97207, USA. chabonr@pdx.edu
LA  - eng
PT  - Introductory Journal Article
DEP - 20111205
PL  - United States
TA  - Semin Speech Lang
JT  - Seminars in speech and language
JID - 8405117
SB  - IM
MH  - *Ethics, Professional
MH  - Humans
MH  - Work/*ethics
EDAT- 2011/12/07 06:00
MHDA- 2012/08/08 06:00
CRDT- 2011/12/07 06:00
PHST- 2011/12/07 06:00 [entrez]
PHST- 2011/12/07 06:00 [pubmed]
PHST- 2012/08/08 06:00 [medline]
AID - 10.1055/s-0031-1292752 [doi]
PST - ppublish
SO  - Semin Speech Lang. 2011 Nov;32(4):277-8. doi: 10.1055/s-0031-1292752. Epub 2011
      Dec 5.


PMID- 22144076
OWN - NLM
STAT- MEDLINE
DCOM- 20120807
LR  - 20111206
IS  - 1098-9056 (Electronic)
IS  - 0734-0478 (Linking)
VI  - 32
IP  - 4
DP  - 2011 Nov
TI  - Setting the stage: the role of ethics at work.
PG  - 273-6
LID - 10.1055/s-0031-1292751 [doi]
FAU - Chabon, Shelly
AU  - Chabon S
AD  - Department of Speech & Hearing Sciences, Portland State University, Portland,
      Oregon 97207, USA. chabonr@pdx.edu
FAU - Donaldson, Amy
AU  - Donaldson A
LA  - eng
PT  - Introductory Journal Article
DEP - 20111205
PL  - United States
TA  - Semin Speech Lang
JT  - Seminars in speech and language
JID - 8405117
SB  - IM
MH  - Decision Making
MH  - Ethics, Professional
MH  - Humans
MH  - *Personal Autonomy
MH  - Speech-Language Pathology/*ethics
EDAT- 2011/12/07 06:00
MHDA- 2012/08/08 06:00
CRDT- 2011/12/07 06:00
PHST- 2011/12/07 06:00 [entrez]
PHST- 2011/12/07 06:00 [pubmed]
PHST- 2012/08/08 06:00 [medline]
AID - 10.1055/s-0031-1292751 [doi]
PST - ppublish
SO  - Semin Speech Lang. 2011 Nov;32(4):273-6. doi: 10.1055/s-0031-1292751. Epub 2011
      Dec 5.


PMID- 22142960
OWN - NLM
STAT- MEDLINE
DCOM- 20120110
LR  - 20220408
IS  - 1420-2433 (Print)
IS  - 0301-536X (Linking)
VI  - 15
DP  - 2012
TI  - Animal models to study host-bacteria interactions involved in periodontitis.
PG  - 117-32
LID - 10.1159/000329675 [doi]
AB  - Animal models have distinct advantages because they can mimic cellular
      complexities that occur in humans in vivo and are often more accurate than in
      vitro studies that take place on plastic surfaces with limited numbers of cell
      types present. Furthermore, cause and effect relationships can be established by 
      applying inhibitors or activators or through the use of genetically modified
      animals. Such gain or loss of function studies are often difficult to achieve in 
      human clinical studies, particularly in obtaining target tissue due to important 
      ethical considerations. Animal models in periodontal disease are particularly
      important at this point in the development of the scientific basis for
      understanding the predominant pathological processes. Periodontal disease can be 
      broken down into discrete steps, each of which may be studied separately
      depending upon the animal model. These steps involve the development of a
      pathogenic biofilm, invasion of connective tissue by bacteria or their products, 
      induction of a destructive host response in connective tissue and limitation of
      are pair process that follows tissue breakdown. Animal studies can test
      hypotheses related to each of these steps, and should be evaluated by their
      capacity to test a specific hypothesis rather than recapitulating all aspects of 
      periodontal disease. Thus, each of the models described below can be adapted to
      test discrete components of the pathological process of periodontal disease, but 
      not necessarily all of them.
CI  - Copyright (c) 2012 S. Karger AG, Basel.
FAU - Graves, Dana T
AU  - Graves DT
AD  - Department of Periodontics, University of Pennsylvania, Philadelphia, PA, USA.
      dtgraves@dental.upenn.edu
FAU - Kang, Jun
AU  - Kang J
FAU - Andriankaja, Oelisoa
AU  - Andriankaja O
FAU - Wada, Keisuke
AU  - Wada K
FAU - Rossa, Carlos Jr
AU  - Rossa C Jr
LA  - eng
GR  - R01 DE017732/DE/NIDCR NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20111111
PL  - Switzerland
TA  - Front Oral Biol
JT  - Frontiers of oral biology
JID - 9812095
RN  - 0 (Lipopolysaccharides)
SB  - IM
MH  - Administration, Oral
MH  - Aggregatibacter actinomycetemcomitans
MH  - Alveolar Bone Loss
MH  - Animals
MH  - Bacteroides
MH  - *Host-Pathogen Interactions
MH  - Humans
MH  - Immunization
MH  - Injections
MH  - Ligation
MH  - Lipopolysaccharides/administration & dosage
MH  - Mandible
MH  - Mice
MH  - *Models, Animal
MH  - Periodontitis/*immunology/*microbiology
MH  - Porphyromonas gingivalis
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Skull
MH  - Treponema denticola
PMC - PMC3766715
MID - NIHMS393743
EDAT- 2011/12/07 06:00
MHDA- 2012/01/11 06:00
CRDT- 2011/12/07 06:00
PHST- 2011/12/07 06:00 [entrez]
PHST- 2011/12/07 06:00 [pubmed]
PHST- 2012/01/11 06:00 [medline]
AID - 000329675 [pii]
AID - 10.1159/000329675 [doi]
PST - ppublish
SO  - Front Oral Biol. 2012;15:117-32. doi: 10.1159/000329675. Epub 2011 Nov 11.


PMID- 22142787
OWN - NLM
STAT- MEDLINE
DCOM- 20120514
LR  - 20120116
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 74
IP  - 2
DP  - 2012 Jan
TI  - Disability and dignity-enabling home environments.
PG  - 211-9
LID - 10.1016/j.socscimed.2011.10.006 [doi]
AB  - In Canada where long-term care is primarily oriented to elderly persons and
      affordable accessible housing is limited, younger disabled adults may be living
      in circumstances that do not meet their health needs and contribute to their
      social exclusion. The purpose of this study was to undertake an ethical analysis 
      of what constitute an 'adequate' home environment for adults with significant
      mobility disabilities. An integrated design was used that combined qualitative
      interviews with normative ethical analysis in an iterative process. Twenty
      interviews with 19 participants were conducted in Ontario, Canada with two
      groups: younger adults (ages 18-55) with mobility disabilities and
      'decision-makers' who consisted of policy makers, program administrators and
      discharge planners. Data were analyzed using a critical disability ethics
      approach and processes of reflective equilibrium. Drawing on Nora Jacobson's
      (Jacobson, 2009) taxonomy of dignity and pluralistic approaches to social
      justice, the concept of 'social dignity' provides a lens for exploring the
      adequacy of home environments for disabled people. Analyses suggested seven
      threshold conditions necessary for a dignity-enabling home: the ability to form
      and sustain meaningful relationships; access to community and civic life; access 
      to control and flexibility of daily activities; access to opportunities for
      self-expression and identity affirmation; access to respectful relationships with
      attendants; access to opportunities to participate in school, work or leisure;
      access to physical, psychological and ontological security. The results have
      implications for housing, health and social care policies, and political reform. 
      Social dignity provides a normative ethical grounding for assessing the adequacy 
      of home environments. The threshold elements outline specific dignity-enabling
      conditions that are open to further specification or elaboration in different
      contexts.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Gibson, Barbara E
AU  - Gibson BE
AD  - Department of Physical Therapy, Faculty of Medicine, University of Toronto,
      Canada. barbara.gibson@utoronto.ca
FAU - Secker, Barbara
AU  - Secker B
FAU - Rolfe, Debbie
AU  - Rolfe D
FAU - Wagner, Frank
AU  - Wagner F
FAU - Parke, Bob
AU  - Parke B
FAU - Mistry, Bhavnita
AU  - Mistry B
LA  - eng
GR  - 87367/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111118
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Architectural Accessibility
MH  - *Disabled Persons
MH  - Ethical Analysis
MH  - Female
MH  - Humans
MH  - Interpersonal Relations
MH  - Interviews as Topic
MH  - Male
MH  - Middle Aged
MH  - *Mobility Limitation
MH  - Ontario
MH  - *Personhood
MH  - *Residence Characteristics
MH  - Safety Management
MH  - *Social Environment
MH  - Social Support
MH  - Young Adult
EDAT- 2011/12/07 06:00
MHDA- 2012/05/15 06:00
CRDT- 2011/12/07 06:00
PHST- 2010/10/06 00:00 [received]
PHST- 2011/07/08 00:00 [revised]
PHST- 2011/10/04 00:00 [accepted]
PHST- 2011/12/07 06:00 [entrez]
PHST- 2011/12/07 06:00 [pubmed]
PHST- 2012/05/15 06:00 [medline]
AID - S0277-9536(11)00647-2 [pii]
AID - 10.1016/j.socscimed.2011.10.006 [doi]
PST - ppublish
SO  - Soc Sci Med. 2012 Jan;74(2):211-9. doi: 10.1016/j.socscimed.2011.10.006. Epub
      2011 Nov 18.


PMID- 22142290
OWN - NLM
STAT- MEDLINE
DCOM- 20120427
LR  - 20151119
IS  - 1708-8240 (Electronic)
IS  - 1496-4155 (Linking)
VI  - 23
IP  - 6
DP  - 2011 Dec
TI  - "Branding" your practice: ethics and excellence.
PG  - 353
LID - 10.1111/j.1708-8240.2011.00489.x [doi]
FAU - Heymann, Harald O
AU  - Heymann HO
AD  - Department of Operative Dentistry, UNC School of Dentistry, University of North
      Carolina at Chapel Hill, NC 27599-7450, USA. harald_heymann@dentistry.unc.edu
LA  - eng
PT  - Journal Article
DEP - 20111117
PL  - England
TA  - J Esthet Restor Dent
JT  - Journal of esthetic and restorative dentistry : official publication of the
      American Academy of Esthetic Dentistry ... [et al.]
JID - 101096515
MH  - Clinical Competence
MH  - *Ethics, Dental
MH  - Humans
MH  - Practice Patterns, Dentists'/ethics/*standards
MH  - *Social Media
EDAT- 2011/12/07 06:00
MHDA- 2012/04/28 06:00
CRDT- 2011/12/07 06:00
PHST- 2011/12/07 06:00 [entrez]
PHST- 2011/12/07 06:00 [pubmed]
PHST- 2012/04/28 06:00 [medline]
AID - 10.1111/j.1708-8240.2011.00489.x [doi]
PST - ppublish
SO  - J Esthet Restor Dent. 2011 Dec;23(6):353. doi: 10.1111/j.1708-8240.2011.00489.x. 
      Epub 2011 Nov 17.


PMID- 22141750
OWN - NLM
STAT- MEDLINE
DCOM- 20120612
LR  - 20220316
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 12
DP  - 2011 Dec 5
TI  - The impact of a cancer Survivorship Care Plan on gynecological cancer patient and
      health care provider reported outcomes (ROGY Care): study protocol for a
      pragmatic cluster randomized controlled trial.
PG  - 256
LID - 10.1186/1745-6215-12-256 [doi]
AB  - BACKGROUND: There is a need for improvement of information provision and
      post-treatment care for cancer survivors. A Survivorship Care Plan (SCP) is
      recommended by the American Institute of Medicine and the Dutch Health Council,
      which is a summary of patients' course of treatment as a formal document, and
      includes recommendations for subsequent cancer surveillance, management of late
      effects, and strategies for health promotion. Until now, evidence on the effects 
      of implementing the SCP in clinical practice is lacking. The rationale and study 
      design of a pragmatic cluster randomized trial, aiming to assess the impact of
      SCP care in routine clinical practice, is presented. METHODS/DESIGN: A web-based 
      patient registration system 'Registrationsystem Oncological GYnecology' (ROGY) is
      used by gynecologists in the South of the Netherlands since 2006. A personalized 
      SCP can automatically be generated out of ROGY. In this pragmatic cluster
      randomized controlled trial, 12 hospitals are randomized to either 'usual care'
      or 'SCP care'. In patients with 'usual care', the gynecologist provides care as
      usual. In patients with 'SCP care', information about the tumor stage and
      treatment is personally discussed with the patient and a document is handed to
      the patient. Prospectively, all patients diagnosed with endometrial or ovarian
      cancer in the participating hospitals will be approached for study participation.
      Patients will complete questionnaires after surgery, and before additional
      treatment, and after 6, 12, 18 and 24 months. In addition, health care providers 
      will be asked their opinion about implementation of SCP care. Primary outcome is 
      defined as patient satisfaction with information provision and care. Secondary
      outcomes are illness perception, health-related quality of life, health care use,
      prevalence, course and referral rate of survivors with psychosocial distress, and
      health care providers' evaluation of SCP care. DISCUSSION: The ROGY Care trial
      will help to gain insight into the impact of SCP care on patient reported
      outcomes, and on the evaluation of cancer survivors and health care providers of 
      the different elements of the SCP. Therefore, results will contribute to efforts 
      to improve quality of care for cancer survivors. TRIAL REGISTRATION: Trial
      Registration: http://www.ClinicalTrials.gov. Identifier: NCT01185626 Medical
      Research Ethics Committee Reference Number: NL33429.008.10 Grant Reference
      Number: UVT2010-4743.
FAU - van de Poll-Franse, Lonneke V
AU  - van de Poll-Franse LV
AD  - CoRPS - Center of Research on Psychology in Somatic Diseases, Department of
      Medical Psychology, Tilburg University, Tilburg, The Netherlands.
      l.vd.poll@uvt.nl
FAU - Nicolaije, Kim A H
AU  - Nicolaije KA
FAU - Vos, Maria C
AU  - Vos MC
FAU - Pijnenborg, Johanna M A
AU  - Pijnenborg JM
FAU - Boll, Dorry
AU  - Boll D
FAU - Husson, Olga
AU  - Husson O
FAU - Ezendam, Nicole P M
AU  - Ezendam NP
FAU - Boss, Erik A
AU  - Boss EA
FAU - Hermans, Ralph H M
AU  - Hermans RH
FAU - Engelhart, Karin C M
AU  - Engelhart KC
FAU - Haartsen, Joke E
AU  - Haartsen JE
FAU - Pijlman, Brenda M
AU  - Pijlman BM
FAU - Feijen, Harrie W H
AU  - Feijen HW
FAU - Mertens, Helena J M M
AU  - Mertens HJ
FAU - Nolting, Willem E
AU  - Nolting WE
FAU - van Beek, Johannes J
AU  - van Beek JJ
FAU - Roukema, Jan A
AU  - Roukema JA
FAU - Kruitwagen, Roy F P M
AU  - Kruitwagen RF
LA  - eng
SI  - ClinicalTrials.gov/NCT01185626
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20111205
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
SB  - IM
MH  - *Clinical Protocols
MH  - Female
MH  - Genital Neoplasms, Female/*mortality/psychology
MH  - Health Personnel
MH  - Humans
MH  - *Outcome Assessment, Health Care
MH  - Patient Satisfaction
MH  - Quality of Life
MH  - Sample Size
MH  - Survival Rate
PMC - PMC3286432
EDAT- 2011/12/07 06:00
MHDA- 2012/06/13 06:00
CRDT- 2011/12/07 06:00
PHST- 2011/09/12 00:00 [received]
PHST- 2011/12/05 00:00 [accepted]
PHST- 2011/12/07 06:00 [entrez]
PHST- 2011/12/07 06:00 [pubmed]
PHST- 2012/06/13 06:00 [medline]
AID - 1745-6215-12-256 [pii]
AID - 10.1186/1745-6215-12-256 [doi]
PST - epublish
SO  - Trials. 2011 Dec 5;12:256. doi: 10.1186/1745-6215-12-256.


PMID- 22141415
OWN - NLM
STAT- MEDLINE
DCOM- 20120425
LR  - 20111206
IS  - 1939-1536 (Electronic)
IS  - 0033-3204 (Linking)
VI  - 48
IP  - 4
DP  - 2011 Dec
TI  - Psychotherapist self-disclosure: ethical and clinical considerations.
PG  - 315-21
LID - 10.1037/a0026056 [doi]
AB  - Self-disclosure is an ever present and unavoidable aspect of psychotherapy. But, 
      why, how, and when it is done requires careful forethought. The use of
      self-disclosure is discussed in the context of boundaries, highlighting its
      ethical and appropriate use in psychotherapy. Rather than avoiding
      self-disclosure out of a fear of violating ethical and professional standards, a 
      thoughtful approach to addressing self-disclosure is presented. Recommendations
      for the ethical and effective use of self-disclosure are provided to include the 
      use of ethical decision-making models and thoughtful consideration of contextual 
      factors that include the psychotherapist's motivations, the client's treatment
      needs and personal history, the psychotherapist's theoretical orientation, and
      individual differences to include each aspect of the client's and
      psychotherapist's diversity. Recommendations for psychotherapists considering the
      use of self-disclosure with clients are made along with specific recommendations 
      for the profession of psychology to provide greater guidance on the ethical,
      effective, and clinically appropriate use of self-disclosure.
FAU - Barnett, Jeffrey E
AU  - Barnett JE
AD  - Department of Psychology, Loyola University Maryland. 4501 N.Charles Street,
      Baltimore, MD 21201, USA. jbarnett@loyola.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Psychotherapy (Chic)
JT  - Psychotherapy (Chicago, Ill.)
JID - 2984829R
SB  - IM
MH  - Health Personnel/*ethics/*psychology
MH  - Humans
MH  - *Professional-Patient Relations
MH  - Psychotherapy/*ethics
MH  - *Self Disclosure
EDAT- 2011/12/07 06:00
MHDA- 2012/04/26 06:00
CRDT- 2011/12/07 06:00
PHST- 2011/12/07 06:00 [entrez]
PHST- 2011/12/07 06:00 [pubmed]
PHST- 2012/04/26 06:00 [medline]
AID - 2011-28195-001 [pii]
AID - 10.1037/a0026056 [doi]
PST - ppublish
SO  - Psychotherapy (Chic). 2011 Dec;48(4):315-21. doi: 10.1037/a0026056.


PMID- 22141379
OWN - NLM
STAT- MEDLINE
DCOM- 20121212
LR  - 20191210
IS  - 1365-2648 (Electronic)
IS  - 0309-2402 (Linking)
VI  - 68
IP  - 7
DP  - 2012 Jul
TI  - Surgical nurses' perceptions of ethical dilemmas, moral distress and quality of
      care.
PG  - 1516-25
LID - 10.1111/j.1365-2648.2011.05897.x [doi]
AB  - AIM: To describe surgical nurses' perceived levels of ethical dilemmas, moral
      distress and perceived quality of care and the associations among them.
      BACKGROUND: Nurses are committed to providing quality care. They can experience
      ethical dilemmas and moral distress while providing patient care. Little research
      has focused on the effect of moral distress or ethical dilemmas on perceived
      quality of care. DESIGN: Descriptive, cross-sectional study. METHOD: After
      administration and institutional Research Ethics Committee approval, a researcher
      requested 119 surgical nurses working in two Israeli hospitals to fill out three 
      questionnaires (personal background characteristics; Ethical Dilemmas in Nursing 
      and Quality of Nursing Care). Data collection took place from August 2007 to
      January 2008. RESULTS: Participant mean age was 39.7 years. The sample consisted 
      mostly of women, Jewish and married staff nurses. The majority of nurses reported
      low to moderate levels of ethical dilemma frequency but intermediate levels of
      ethical dilemma intensity. Frequency of ethical dilemmas was negatively
      correlated with level of nursing skill, meeting patient's needs and total quality
      of care. No important correlations were found between intensity of ethical
      dilemmas and quality of care. CONCLUSIONS: Levels of ethical dilemma frequency
      were higher than intensity. Nurses tended to be satisfied with their level of
      quality of care. Increased frequency of ethical dilemmas was associated with some
      aspects of perceived quality of care. RELEVANCE TO CLINICAL PRACTICE: Quality of 
      care is related to ethical dilemmas and moral distress among surgical nurses.
      Therefore, efforts should be made to decrease the frequency of these feelings to 
      improve the quality of patient care.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - DeKeyser Ganz, Freda
AU  - DeKeyser Ganz F
AD  - Head Masters Program, School of Nursing, Hadassah Hebrew University, Jerusalem,
      Israel. freda@hadassah.org.il
FAU - Berkovitz, Keren
AU  - Berkovitz K
LA  - eng
PT  - Journal Article
DEP - 20111206
PL  - England
TA  - J Adv Nurs
JT  - Journal of advanced nursing
JID - 7609811
SB  - IM
MH  - Adult
MH  - Attitude of Health Personnel
MH  - Choice Behavior/*ethics
MH  - *Conflict, Psychological
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Israel
MH  - Male
MH  - Middle Aged
MH  - Morals
MH  - Nursing Staff, Hospital/*psychology
MH  - Perioperative Nursing/*ethics/standards
MH  - Quality of Health Care/*ethics/standards
MH  - Stress, Psychological/psychology
MH  - *Surveys and Questionnaires
MH  - Young Adult
EDAT- 2011/12/07 06:00
MHDA- 2012/12/13 06:00
CRDT- 2011/12/07 06:00
PHST- 2011/12/07 06:00 [entrez]
PHST- 2011/12/07 06:00 [pubmed]
PHST- 2012/12/13 06:00 [medline]
AID - 10.1111/j.1365-2648.2011.05897.x [doi]
PST - ppublish
SO  - J Adv Nurs. 2012 Jul;68(7):1516-25. doi: 10.1111/j.1365-2648.2011.05897.x. Epub
      2011 Dec 6.


PMID- 22102302
OWN - NLM
STAT- MEDLINE
DCOM- 20120222
LR  - 20211203
IS  - 1548-6869 (Electronic)
IS  - 1049-2089 (Linking)
VI  - 22
IP  - 4 Suppl
DP  - 2011
TI  - Partnering to harmonize IRBs for community-engaged research to reduce health
      disparities.
PG  - 8-15
LID - 10.1353/hpu.2011.0157 [doi]
AB  - Emerging advances in health disparities research include controlled trials and
      comparative effectiveness studies that are frequently conducted at multiple
      community and academic sites. Review by different institutional review boards
      (IRBs) presents a major impediment to the timely and effective conduct of such
      research. When research involves minority and underserved communities as well as 
      multiple geographic regions, institutional requirements and interpretation of
      ethical standards may vary substantially. Such variations can complicate the
      informed consent process and research protocol, and may undermine participant
      respect and trial quality. In addition, multiple IRB review can lead to
      unnecessary delays, jeopardizing funding and capacity to perform collaborative
      projects. In response to these issues, the Research Centers in Minority
      Institutions (RCMI) Translational Research Network (RTRN) is developing a
      community-partnered approach to streamlining IRB review across its consortium of 
      18 RCMI grantee institutions that will ensure compliance while enhancing the
      quality of health disparities research.
FAU - Hammatt, Zoe H
AU  - Hammatt ZH
AD  - William S. Richardson School of Law, University of Hawaii, 2515 Dole Street,
      Honolulu, HI 96822, USA. hammatt@hawaii.edu
FAU - Nishitani, Junko
AU  - Nishitani J
FAU - Heslin, Kevin C
AU  - Heslin KC
FAU - Perry, M Theresa
AU  - Perry MT
FAU - Szetela, Carolyn
AU  - Szetela C
FAU - Jones, Loretta
AU  - Jones L
FAU - Williams, Pluscedia
AU  - Williams P
FAU - Antoine-LaVigne, Donna
AU  - Antoine-LaVigne D
FAU - Forge, Nell G
AU  - Forge NG
FAU - Norris, Keith C
AU  - Norris KC
LA  - eng
GR  - UL1 RR033176/RR/NCRR NIH HHS/United States
GR  - U54 RR026136/RR/NCRR NIH HHS/United States
GR  - U54 RR022762/RR/NCRR NIH HHS/United States
GR  - U54 MD007598/MD/NIMHD NIH HHS/United States
GR  - UL1 TR000124/TR/NCATS NIH HHS/United States
GR  - P20 MD000182/MD/NIMHD NIH HHS/United States
GR  - U54RR022762-03S2/RR/NCRR NIH HHS/United States
GR  - U54 MD007584/MD/NIMHD NIH HHS/United States
GR  - S21 MD000103/MD/NIMHD NIH HHS/United States
GR  - U54 RR026138/RR/NCRR NIH HHS/United States
GR  - MD000103/MD/NIMHD NIH HHS/United States
GR  - U54RR026136-01A1/RR/NCRR NIH HHS/United States
GR  - RR026138/RR/NCRR NIH HHS/United States
GR  - RR022762/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Health Care Poor Underserved
JT  - Journal of health care for the poor and underserved
JID - 9103800
SB  - IM
MH  - Community-Institutional Relations
MH  - *Cooperative Behavior
MH  - *Ethics Committees, Research
MH  - Health Services Research/*organization & administration
MH  - *Healthcare Disparities
MH  - Humans
MH  - *Translational Research, Biomedical
MH  - United States
PMC - PMC3579219
MID - NIHMS394842
EDAT- 2011/12/07 06:00
MHDA- 2012/02/23 06:00
CRDT- 2011/11/22 06:00
PHST- 2011/11/22 06:00 [entrez]
PHST- 2011/12/07 06:00 [pubmed]
PHST- 2012/02/23 06:00 [medline]
AID - S1548686911400036 [pii]
AID - 10.1353/hpu.2011.0157 [doi]
PST - ppublish
SO  - J Health Care Poor Underserved. 2011;22(4 Suppl):8-15. doi:
      10.1353/hpu.2011.0157.


PMID- 22085416
OWN - NLM
STAT- MEDLINE
DCOM- 20120319
LR  - 20211021
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 25 Suppl 1
DP  - 2011 Nov
TI  - End-of-life decision-making in Canada: the report by the Royal Society of Canada 
      expert panel on end-of-life decision-making.
PG  - 1-73
LID - 10.1111/j.1467-8519.2011.01939.x [doi]
AB  - This report on end-of-life decision-making in Canada was produced by an
      international expert panel and commissioned by the Royal Society of Canada. It
      consists of five chapters. Chapter 1 reviews what is known about end-of-life care
      and opinions about assisted dying in Canada. Chapter 2 reviews the legal status
      quo in Canada with regard to various forms of assisted death. Chapter 3 reviews
      ethical issues pertaining to assisted death. The analysis is grounded in core
      values central to Canada's constitutional order. Chapter 4 reviews the
      experiences had in a number of jurisdictions that have decriminalized or recently
      reviewed assisted dying in some shape or form. Chapter 5 provides recommendations
      with regard to the provision of palliative care in Canada, as well as
      recommendations for reform with respect to the various forms of assisted death
      covered in this document.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Schuklenk, Udo
AU  - Schuklenk U
AD  - Department of Philosophy, Queen's University, Canada. udo.schuklenk@gmail.com
FAU - van Delden, Johannes J M
AU  - van Delden JJ
FAU - Downie, Jocelyn
AU  - Downie J
FAU - McLean, Sheila A M
AU  - McLean SA
FAU - Upshur, Ross
AU  - Upshur R
FAU - Weinstock, Daniel
AU  - Weinstock D
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Adult
MH  - Advance Directives
MH  - Aged
MH  - Bioethical Issues
MH  - Canada
MH  - Child
MH  - Decision Making
MH  - Deep Sedation
MH  - Europe
MH  - Euthanasia, Active, Voluntary
MH  - Humans
MH  - Palliative Care
MH  - Public Opinion
MH  - Suicide, Assisted/legislation & jurisprudence
MH  - *Terminal Care
MH  - United States
MH  - Withholding Treatment
PMC - PMC3265521
EDAT- 2011/12/07 06:00
MHDA- 2012/03/20 06:00
CRDT- 2011/11/17 06:00
PHST- 2011/11/17 06:00 [entrez]
PHST- 2011/12/07 06:00 [pubmed]
PHST- 2012/03/20 06:00 [medline]
AID - 10.1111/j.1467-8519.2011.01939.x [doi]
PST - ppublish
SO  - Bioethics. 2011 Nov;25 Suppl 1:1-73. doi: 10.1111/j.1467-8519.2011.01939.x.


PMID- 22085131
OWN - NLM
STAT- MEDLINE
DCOM- 20111230
LR  - 20111117
IS  - 1464-410X (Electronic)
IS  - 1464-4096 (Linking)
VI  - 108 Suppl 2
DP  - 2011 Nov
TI  - Patients' perceptions of surgical registrars' training in the private hospital
      setting.
PG  - 58-61
LID - 10.1111/j.1464-410X.2011.10697.x [doi]
AB  - UNLABELLED: What's known on the subject? and What does the study add? The
      Australian private health sector is increasingly being recognised as an
      opportunity for advanced surgical training. Little is known about what the
      patients think of urology training in the private sector. Patients perceptions on
      the place of urology registrars in the Australian private sector are assessed for
      the first time. We can confirm that there appears to be acceptance of urology
      training in the private sector. OBJECTIVE: * To determine the acceptance of
      surgical trainees in a private hospital setting. METHOD: * This was an ethics
      approved prospective study using a written survey. * A total of 177 consecutive
      patients presenting for private consultation were recruited. A self-administered 
      written survey was completed by each patient in the waiting room prior to
      consultation. RESULTS: * Only 36.8% of subjects (confidence interval 29.6-44.1)
      initially understood the term registrar which significantly increased to 75%
      (confidence interval 68.4-81.6, P < 0.05) after reading explanatory notes. *
      Perceived differences between private and public hospitals were choice of surgeon
      (28%), waiting times for an operation (28%), standard of care (17%), cost (16%)
      and waiting times for an appointment (11%). * Patients' acceptance of registrar
      involvement with either a small part of an operation, a large part of an
      operation, the whole operation and assistance only were 34%, 16%, 13% and 37%.
      CONCLUSIONS: * Patients have a poor understanding of the term registrar. *
      Acceptance of registrars in private hospitals is increased if consultant
      involvement is emphasized. * Surgical assistance and performance of minor parts
      of surgery by trainees is well accepted.
CI  - (c) 2011 THE AUTHORS. BJU INTERNATIONAL (c) 2011 BJU INTERNATIONAL.
FAU - Huynh, Chi C
AU  - Huynh CC
AD  - Westmead Hospital - Urology, Sydney, Australia.
FAU - Brooks, Andrew J
AU  - Brooks AJ
FAU - Nicol, David
AU  - Nicol D
FAU - Woo, Henry H
AU  - Woo HH
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - England
TA  - BJU Int
JT  - BJU international
JID - 100886721
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Communication
MH  - *Education, Medical, Graduate
MH  - Female
MH  - Hospitals, Private/*statistics & numerical data
MH  - Humans
MH  - Male
MH  - Medical Staff, Hospital/*education
MH  - Middle Aged
MH  - Motivation
MH  - New South Wales
MH  - *Patient Satisfaction
MH  - Perception
MH  - Physician-Patient Relations
MH  - Prospective Studies
MH  - Urology/*education
MH  - Young Adult
EDAT- 2011/12/07 06:00
MHDA- 2011/12/31 06:00
CRDT- 2011/11/17 06:00
PHST- 2011/11/17 06:00 [entrez]
PHST- 2011/12/07 06:00 [pubmed]
PHST- 2011/12/31 06:00 [medline]
AID - 10.1111/j.1464-410X.2011.10697.x [doi]
PST - ppublish
SO  - BJU Int. 2011 Nov;108 Suppl 2:58-61. doi: 10.1111/j.1464-410X.2011.10697.x.


PMID- 22079933
OWN - NLM
STAT- MEDLINE
DCOM- 20120321
LR  - 20220311
IS  - 1460-2245 (Electronic)
IS  - 0957-4824 (Linking)
VI  - 26 Suppl 1
DP  - 2011 Dec
TI  - Supporting decision-making processes for evidence-based mental health promotion.
PG  - i140-6
LID - 10.1093/heapro/dar076 [doi]
AB  - The use of evidence is critical in guiding decision-making, but evidence from
      effect studies will be only one of a number of factors that will need to be taken
      into account in the decision-making processes. Equally important for policymakers
      will be the use of different types of evidence including implementation
      essentials and other decision-making principles such as social justice,
      political, ethical, equity issues, reflecting public attitudes and the level of
      resources available, rather than be based on health outcomes alone. This paper,
      aimed to support decision-makers, highlights the importance of commissioning
      high-quality evaluations, the key aspects to assess levels of evidence, the
      importance of supporting evidence-based implementation and what to look out for
      before, during and after implementation of mental health promotion and mental
      disorder prevention programmes.
FAU - Jane-Llopis, Eva
AU  - Jane-Llopis E
AD  - World Economic Forum, Geneva, Switzerland. ejl@weforum.org
FAU - Katschnig, Heinz
AU  - Katschnig H
FAU - McDaid, David
AU  - McDaid D
FAU - Wahlbeck, Kristian
AU  - Wahlbeck K
LA  - eng
PT  - Journal Article
PL  - England
TA  - Health Promot Int
JT  - Health promotion international
JID - 9008939
SB  - IM
MH  - *Decision Making
MH  - *Evidence-Based Medicine
MH  - Health Promotion/*methods
MH  - Humans
MH  - Mental Disorders/prevention & control
MH  - *Mental Health
EDAT- 2011/12/07 06:00
MHDA- 2012/03/22 06:00
CRDT- 2011/11/15 06:00
PHST- 2011/11/15 06:00 [entrez]
PHST- 2011/12/07 06:00 [pubmed]
PHST- 2012/03/22 06:00 [medline]
AID - dar076 [pii]
AID - 10.1093/heapro/dar076 [doi]
PST - ppublish
SO  - Health Promot Int. 2011 Dec;26 Suppl 1:i140-6. doi: 10.1093/heapro/dar076.


PMID- 27646042
OWN - NLM
STAT- Publisher
LR  - 20191120
IS  - 1354-5752 (Print)
IS  - 1354-5752 (Linking)
VI  - 19
IP  - 8
DP  - 2011 Dec 7
TI  - Ethics of triage.
PG  - 13-27
AB  - As this article makes clear, triage can have adverse consequences for patients
      receiving emergency care, who can therefore challenge the ethical basis of such
      practice.
FAU - Lumsden, Karen
AU  - Lumsden K
AD  - Canterbury Christ Church University, and emergency department sister at East Kent
      Hospitals University NHS Foundation Trust, Ashford.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Emerg Nurse
JT  - Emergency nurse : the journal of the RCN Accident and Emergency Nursing
      Association
JID - 9208913
EDAT- 2011/12/07 00:00
MHDA- 2011/12/07 00:00
CRDT- 2016/09/21 06:00
PHST- 2016/09/21 06:00 [entrez]
PHST- 2011/12/07 00:00 [pubmed]
PHST- 2011/12/07 00:00 [medline]
AID - 10.7748/en.19.8.13.s13 [doi]
PST - ppublish
SO  - Emerg Nurse. 2011 Dec 7;19(8):13-27. doi: 10.7748/en.19.8.13.s13.


PMID- 22140353
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1477-7509 (Print)
IS  - 1477-7509 (Linking)
VI  - 6
IP  - 1
DP  - 2011 Mar
TI  - Disability: a welfarist approach.
PG  - 45-51
AB  - In this paper, we offer a new account of disability. According to our account,
      some state of a person's biology or psychology is a disability if that state
      makes it more likely that a person's life will get worse, in terms of his or her 
      own wellbeing, in a given set of social and environmental circumstances. Unlike
      the medical model of disability, our welfarist approach does not tie disability
      to deviation from normal species' functioning, nor does it understand disability 
      in essentialist terms. Like the social model of disability, the welfarist
      approach sees disability as a harmful state that results from the interaction
      between a person's biology and psychology and his or her surrounding environment.
      However, unlike the social model, it denies that the harm associated with
      disability is entirely due to social prejudice or injustice. In this paper, we
      outline and clarify the welfarist approach, answer common objections and
      illustrate its usefulness in addressing a range of difficult ethical questions
      involving disability.
FAU - Savulescu, Julian
AU  - Savulescu J
AD  - Oxford Uehiro Centre for Practical Ethics, University of Oxford , Littlegate
      House, St Ebbes Street, Oxford OX1 1PT , UK.
FAU - Kahane, Guy
AU  - Kahane G
LA  - eng
GR  - 086041/WT_/Wellcome Trust/United Kingdom
GR  - 087208/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PL  - England
TA  - Clin Ethics
JT  - Clinical ethics
JID - 101294546
PMC - PMC3227811
EDAT- 2011/12/06 06:00
MHDA- 2011/12/06 06:01
CRDT- 2011/12/06 06:00
PHST- 2011/12/06 06:00 [entrez]
PHST- 2011/12/06 06:00 [pubmed]
PHST- 2011/12/06 06:01 [medline]
AID - 10.1258/ce.2011.011010 [doi]
AID - CE-11-010 [pii]
PST - ppublish
SO  - Clin Ethics. 2011 Mar;6(1):45-51. doi: 10.1258/ce.2011.011010.


PMID- 22140189
OWN - NLM
STAT- MEDLINE
DCOM- 20120510
LR  - 20120202
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 19
IP  - 1
DP  - 2012 Jan
TI  - The experience of lying in dementia care: a qualitative study.
PG  - 7-20
LID - 10.1177/0969733011412104 [doi]
AB  - This analysis examines the practice of care providers in residential aged care
      lying to residents with dementia. Qualitative data were collected through
      multiple methods. Data here represents perceptions from registered and enrolled
      nurses, personal care assistants, and allied health professionals from five
      residential aged care facilities located in Queensland, Australia. Care providers
      in residential aged care facilities (RACFs) lie to residents with dementia. Lying
      is conceptualized as therapeutic whereby the care provider's intent is to
      eliminate harm and also control behaviour. Care providers of residents with
      dementia in RACFs need guidance around lying. An ethical framework cognisant of
      an ethical theory of good and ethical theory of right supplemented by a theory of
      virtue is proposed. A complimentary four stage communication strategy that
      promotes truth telling as a first option while also recommending the lie as a
      suitable strategy is also promoted.
FAU - Tuckett, Anthony G
AU  - Tuckett AG
AD  - The University of Queensland, School of Nursing & Midwifery, Brisbane,
      Queensland, Australia. a.tuckett@uq.edu.au
LA  - eng
PT  - Journal Article
DEP - 20111202
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Adult
MH  - Aged
MH  - *Attitude of Health Personnel
MH  - Communication
MH  - *Deception
MH  - Dementia/*nursing/therapy
MH  - Ethics, Nursing
MH  - Female
MH  - *Homes for the Aged
MH  - Humans
MH  - Middle Aged
MH  - Nursing Methodology Research
MH  - Nursing Staff/*psychology
MH  - Qualitative Research
MH  - Queensland
EDAT- 2011/12/06 06:00
MHDA- 2012/05/11 06:00
CRDT- 2011/12/06 06:00
PHST- 2011/12/06 06:00 [entrez]
PHST- 2011/12/06 06:00 [pubmed]
PHST- 2012/05/11 06:00 [medline]
AID - 0969733011412104 [pii]
AID - 10.1177/0969733011412104 [doi]
PST - ppublish
SO  - Nurs Ethics. 2012 Jan;19(1):7-20. doi: 10.1177/0969733011412104. Epub 2011 Dec 2.


PMID- 22140188
OWN - NLM
STAT- MEDLINE
DCOM- 20120510
LR  - 20120202
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 19
IP  - 1
DP  - 2012 Jan
TI  - An explorative study of experiences of healthcare providers posing as simulated
      care receivers in a 'care-ethical' lab.
PG  - 68-79
LID - 10.1177/0969733011412103 [doi]
AB  - In recent approaches to ethics, the personal involvement of health care providers
      and their empathy are perceived as important elements of an overall ethical
      ability. Experiential working methods are used in ethics education to foster,
      inter alia, empathy. In 2008, the care-ethics lab 'sTimul' was founded in
      Flanders, Belgium, to provide training that focuses on improving care providers' 
      ethical abilities through experiential working simulations. The curriculum of
      sTimul focuses on empathy sessions, aimed at care providers' empathic skills. The
      present study provides better insight into how experiential learning specifically
      targets the empathic abilities of care providers. Providing contrasting
      experiences that affect the care providers' self-reflection seems a crucial
      element in this study. Further research is needed to provide more insight into
      how empathy leads to long-term changes in behaviour.
FAU - Vanlaere, Linus
AU  - Vanlaere L
AD  - sTimul: care-ethics lab, Sint-Maartensplein 13, Moorsele, Belgium.
      Linus.Vanlaere@med.kuleuven.be
FAU - Timmermann, Madeleine
AU  - Timmermann M
FAU - Stevens, Marleen
AU  - Stevens M
FAU - Gastmans, Chris
AU  - Gastmans C
LA  - eng
PT  - Journal Article
DEP - 20111202
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Adult
MH  - Aged
MH  - *Attitude of Health Personnel
MH  - *Empathy
MH  - Ethics, Medical/*education
MH  - Female
MH  - Health Services for the Aged/ethics
MH  - Humans
MH  - Male
MH  - Medical Staff/education/*psychology
MH  - Nursing Education Research
MH  - Nursing Methodology Research
MH  - Nursing Staff/education/*psychology
MH  - Patient Simulation
MH  - Problem-Based Learning
MH  - Role Playing
EDAT- 2011/12/06 06:00
MHDA- 2012/05/11 06:00
CRDT- 2011/12/06 06:00
PHST- 2011/12/06 06:00 [entrez]
PHST- 2011/12/06 06:00 [pubmed]
PHST- 2012/05/11 06:00 [medline]
AID - 0969733011412103 [pii]
AID - 10.1177/0969733011412103 [doi]
PST - ppublish
SO  - Nurs Ethics. 2012 Jan;19(1):68-79. doi: 10.1177/0969733011412103. Epub 2011 Dec
      2.


PMID- 22140187
OWN - NLM
STAT- MEDLINE
DCOM- 20120510
LR  - 20120202
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 19
IP  - 1
DP  - 2012 Jan
TI  - The challenge of integrating justice and care in neonatal nursing.
PG  - 80-90
LID - 10.1177/0969733011412101 [doi]
AB  - The aim of this study was to explore neonatal nurses' and mothers of preterm
      infants' experiences of daily challenges. Interviews took place asking for good, 
      bad and challenging experiences. Data were analysed using qualitative content
      analysis and findings were clustered in two categories: good and challenging
      experiences, each containing three themes. The good experiences were: managing
      with success as a nurse, small things matter for mothers, and a good day anyhow
      for mothers and nurses. The challenging experiences were: mothering in public,
      being pulled between responsibilities, and adverse things stick under the nurses'
      skin. The study shows that small daily clinical matters become big issues and
      could lead to moral distress, and that nurses integrate ethics of justice and
      ethics of care while mothers are concerned about health and well-being of their
      specific infant only. The challenge for nursing to integrate fairness and
      sensitive care in family-oriented neonatal care is discussed.
FAU - Hall, Elisabeth O C
AU  - Hall EO
AD  - Faculty of Health Sciences, Department of Public Health, Aarhus University,
      HoeghGuldbergs Gade 6A, Aarhus C, Denmark. eh@nursingscience.au.dk
FAU - Brinchmann, Berit S
AU  - Brinchmann BS
FAU - Aagaard, Hanne
AU  - Aagaard H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111202
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - *Attitude to Health
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Middle Aged
MH  - Mothers/*psychology
MH  - Neonatal Nursing/*ethics
MH  - Nursing Methodology Research
MH  - Nursing Staff, Hospital/*psychology
MH  - Qualitative Research
MH  - *Social Justice
MH  - Young Adult
EDAT- 2011/12/06 06:00
MHDA- 2012/05/11 06:00
CRDT- 2011/12/06 06:00
PHST- 2011/12/06 06:00 [entrez]
PHST- 2011/12/06 06:00 [pubmed]
PHST- 2012/05/11 06:00 [medline]
AID - 0969733011412101 [pii]
AID - 10.1177/0969733011412101 [doi]
PST - ppublish
SO  - Nurs Ethics. 2012 Jan;19(1):80-90. doi: 10.1177/0969733011412101. Epub 2011 Dec
      2.


PMID- 22140186
OWN - NLM
STAT- MEDLINE
DCOM- 20120510
LR  - 20220409
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 19
IP  - 1
DP  - 2012 Jan
TI  - Perceived ethical values by Iranian nurses.
PG  - 30-44
LID - 10.1177/0969733011408169 [doi]
AB  - Nursing, a scientific and practical discipline, faces continuing challenges of
      finding new direction in order to decipher its core values and develop current
      ethical codes for nursing practice. In 2009-10, 28 nurses were purposely selected
      and interviewed using a semi-structured format in focus groups and individually. 
      Thematic Content Analysis helped explore the perception of Iranian nurses on
      ethical values in patient care. Seven major themes emerged: respect for dignity, 
      professional integrity, professional commitment, developing human relationships, 
      justice, honesty, and promoting individuals and the nursing profession. Iranian
      nurses revealed a unique and culture-based set of ethical values. This study
      found that Iranian nurses place a greater emphasis on preserving the dignity of
      those accompanying the patient and in showing regard for patients' religious
      beliefs in a gender appropriate environment.
FAU - Shahriari, Mohsen
AU  - Shahriari M
AD  - Isfahan University of Medical Sciences, Isfahan, Iran.
FAU - Mohammadi, Eesa
AU  - Mohammadi E
FAU - Abbaszadeh, Abbas
AU  - Abbaszadeh A
FAU - Bahrami, Masoud
AU  - Bahrami M
FAU - Fooladi, Marjaneh M
AU  - Fooladi MM
LA  - eng
PT  - Journal Article
DEP - 20111202
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - *Ethics, Nursing
MH  - Female
MH  - Humans
MH  - Iran
MH  - Male
MH  - Middle Aged
MH  - Nursing Staff, Hospital/*psychology
MH  - Qualitative Research
EDAT- 2011/12/06 06:00
MHDA- 2012/05/11 06:00
CRDT- 2011/12/06 06:00
PHST- 2011/12/06 06:00 [entrez]
PHST- 2011/12/06 06:00 [pubmed]
PHST- 2012/05/11 06:00 [medline]
AID - 0969733011408169 [pii]
AID - 10.1177/0969733011408169 [doi]
PST - ppublish
SO  - Nurs Ethics. 2012 Jan;19(1):30-44. doi: 10.1177/0969733011408169. Epub 2011 Dec
      2.


PMID- 22140185
OWN - NLM
STAT- MEDLINE
DCOM- 20120719
LR  - 20120329
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 19
IP  - 2
DP  - 2012 Mar
TI  - A proto-code of ethics and conduct for European nurse directors.
PG  - 279-88
LID - 10.1177/0969733011413492 [doi]
AB  - The proto-code of ethics and conduct for European nurse directors was developed
      as a strategic and dynamic document for nurse managers in Europe. It invites
      critical dialogue, reflective thinking about different situations, and the
      development of specific codes of ethics and conduct by nursing associations in
      different countries. The term proto-code is used for this document so that
      specifically country-orientated or organization-based and practical codes can be 
      developed from it to guide professionals in more particular or situation-explicit
      reflection and values. The proto-code of ethics and conduct for European nurse
      directors was designed and developed by the European Nurse Directors
      Association's (ENDA) advisory team. This article gives short explanations of the 
      code' s preamble and two main parts: Nurse directors' ethical basis, and
      Principles of professional practice, which is divided into six specific points:
      competence, care, safety, staff, life-long learning and multi-sectorial working.
FAU - Stievano, Alessandro
AU  - Stievano A
AD  - European Nurse Directors Association advisory team. alessandro.stievano@gmail.com
FAU - De Marinis, Maria Grazia
AU  - De Marinis MG
FAU - Kelly, Denise
AU  - Kelly D
FAU - Filkins, Jacqueline
AU  - Filkins J
FAU - Meyenburg-Altwarg, Iris
AU  - Meyenburg-Altwarg I
FAU - Petrangeli, Mauro
AU  - Petrangeli M
FAU - Tschudin, Verena
AU  - Tschudin V
LA  - eng
PT  - Journal Article
DEP - 20111202
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - *Codes of Ethics
MH  - Europe
MH  - *Guidelines as Topic
MH  - Humans
MH  - Nurse Administrators/*ethics/standards
MH  - *Principle-Based Ethics
MH  - Problem-Based Learning/ethics
EDAT- 2011/12/06 06:00
MHDA- 2012/07/20 06:00
CRDT- 2011/12/06 06:00
PHST- 2011/12/06 06:00 [entrez]
PHST- 2011/12/06 06:00 [pubmed]
PHST- 2012/07/20 06:00 [medline]
AID - 0969733011413492 [pii]
AID - 10.1177/0969733011413492 [doi]
PST - ppublish
SO  - Nurs Ethics. 2012 Mar;19(2):279-88. doi: 10.1177/0969733011413492. Epub 2011 Dec 
      2.


PMID- 22140184
OWN - NLM
STAT- MEDLINE
DCOM- 20120510
LR  - 20220408
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 19
IP  - 1
DP  - 2012 Jan
TI  - Balancing truth-telling in the preservation of hope: a relational ethics
      approach.
PG  - 21-9
LID - 10.1177/0969733011418551 [doi]
AB  - Truth-telling in healthcare practice can be regarded as a universal communicative
      virtue; however, there are different views on what consequence it has for giving 
      or diminishing hope. The aim of this article is to explore the relationship
      between the concepts of truth-telling and hope from a relational ethics approach 
      in the context of healthcare practice. Healthcare staff protect themselves and
      others to preserve hope in the care of seriously sick patients and in end-of-life
      care. This is done by balancing truth-telling guided by different conditions such
      as the cultural norms of patients, family and staff. Our main conclusion is that 
      the balancing of truth-telling needs to be decided in a mutual understanding in
      the caring relationship, but hope must always be inspired. Instead of focusing on
      autonomy as the only guiding principle, we would like to propose that relational 
      ethics can serve as a meaningful perspective in balancing truth-telling.
FAU - Pergert, Pernilla
AU  - Pergert P
AD  - Department of Women's and Children's Health, Karolinska Institutet, Stockholm,
      Sweden. pernilla.pergert@ki.se
FAU - Lutzen, Kim
AU  - Lutzen K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111202
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - *Attitude of Health Personnel
MH  - Cultural Characteristics
MH  - Emotions
MH  - Family/psychology
MH  - Humans
MH  - Medical Staff/*psychology
MH  - Nursing Staff/*psychology
MH  - Professional-Patient Relations/*ethics
MH  - Terminal Care/ethics/psychology
MH  - Truth Disclosure/*ethics
EDAT- 2011/12/06 06:00
MHDA- 2012/05/11 06:00
CRDT- 2011/12/06 06:00
PHST- 2011/12/06 06:00 [entrez]
PHST- 2011/12/06 06:00 [pubmed]
PHST- 2012/05/11 06:00 [medline]
AID - 0969733011418551 [pii]
AID - 10.1177/0969733011418551 [doi]
PST - ppublish
SO  - Nurs Ethics. 2012 Jan;19(1):21-9. doi: 10.1177/0969733011418551. Epub 2011 Dec 2.


PMID- 22140182
OWN - NLM
STAT- MEDLINE
DCOM- 20120510
LR  - 20191210
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 19
IP  - 1
DP  - 2012 Jan
TI  - Ethical problems in practice as experienced by Malawian student nurses.
PG  - 128-38
LID - 10.1177/0969733011412106 [doi]
AB  - Student nurses are confronted by many ethical challenges in clinical practice.
      The aim of the study was to explore Malawian students' experiences of ethical
      problems during their clinical placement. A phenomenological hermeneutic design
      comprising interviews and qualitative content analysis was used. Ten students
      were interviewed. Three main themes emerged: 1) Conflict between patient rights
      and the guardians' presence in the hospital; 2) Conflict between violation of
      professional values and patient rights caused by unethical behaviour; and 3)
      Conflict between moral awareness and the ideal course of action. The students had
      difficulties ensuring patient rights and acting in accordance with western norms 
      and values which are not always appropriate in the Malawian context. The students
      require role models who demonstrate professional attitudes towards patients'
      rights and values. There is a need to create pedagogical strategies in which a
      caring attitude and ethical reflection can be learned and cultivated in clinical 
      practice.
FAU - Solum, Eva Merethe
AU  - Solum EM
AD  - Department of Nursing Science, Faculty of Health Science, Vestfold University
      College, Tonsberg, Norway. eva.m.solum@hive.no
FAU - Maluwa, Veronica Mary
AU  - Maluwa VM
FAU - Severinsson, Elisabeth
AU  - Severinsson E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111202
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Conflict, Psychological
MH  - *Ethics, Nursing
MH  - Female
MH  - Humans
MH  - Malawi
MH  - Male
MH  - Nursing Evaluation Research
MH  - Nursing Methodology Research
MH  - Qualitative Research
MH  - Students, Nursing/*psychology
EDAT- 2011/12/06 06:00
MHDA- 2012/05/11 06:00
CRDT- 2011/12/06 06:00
PHST- 2011/12/06 06:00 [entrez]
PHST- 2011/12/06 06:00 [pubmed]
PHST- 2012/05/11 06:00 [medline]
AID - 0969733011412106 [pii]
AID - 10.1177/0969733011412106 [doi]
PST - ppublish
SO  - Nurs Ethics. 2012 Jan;19(1):128-38. doi: 10.1177/0969733011412106. Epub 2011 Dec 
      2.


PMID- 22140181
OWN - NLM
STAT- MEDLINE
DCOM- 20120510
LR  - 20120202
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 19
IP  - 1
DP  - 2012 Jan
TI  - Duties of the patient: a tentative model based on metasynthesis.
PG  - 58-67
LID - 10.1177/0969733011412105 [doi]
AB  - Patient's duties are a topical but little researched area in nursing ethics.
      However, patient's duties are closely connected to nursing practice in terms of
      autonomy, the best purpose of care and rethinking from the patient's perspective.
      This article is a metasynthesis (N = 11 original articles) of patient's duties,
      aimed to create a tentative model. In this article, a tentative model called
      'right-based duties of a patient' was constructed. With its aid, a coherent
      structure of patient's duties within different roles and objects of a patient can
      be defined. In addition, the ethical basis, prerequisites, outcomes and risks of 
      patient's duties can be named. In conclusion, so-called right-based duties of a
      patient constitute the basic argument. Patient's duties are not unambiguous for
      all patients, and the global perspective to duties has been challenged. However, 
      due to both conceptual and practical reasons, rethinking of patient's duties is
      needed.
FAU - Kangasniemi, Mari
AU  - Kangasniemi M
AD  - Department of Nursing Science, Faculty of Health Sciences, University of Eastern 
      Finland, Kuopio, Finland. mari.kangasniemi@uef.fi
FAU - Halkoaho, Arja
AU  - Halkoaho A
FAU - Lansimies-Antikainen, Helena
AU  - Lansimies-Antikainen H
FAU - Pietila, Anna-Maija
AU  - Pietila AM
LA  - eng
PT  - Journal Article
DEP - 20111202
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Ethics, Nursing
MH  - Humans
MH  - Meta-Analysis as Topic
MH  - *Models, Nursing
MH  - *Patient Participation
MH  - Patient Rights
EDAT- 2011/12/06 06:00
MHDA- 2012/05/11 06:00
CRDT- 2011/12/06 06:00
PHST- 2011/12/06 06:00 [entrez]
PHST- 2011/12/06 06:00 [pubmed]
PHST- 2012/05/11 06:00 [medline]
AID - 0969733011412105 [pii]
AID - 10.1177/0969733011412105 [doi]
PST - ppublish
SO  - Nurs Ethics. 2012 Jan;19(1):58-67. doi: 10.1177/0969733011412105. Epub 2011 Dec
      2.


PMID- 22140180
OWN - NLM
STAT- MEDLINE
DCOM- 20120510
LR  - 20120202
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 19
IP  - 1
DP  - 2012 Jan
TI  - Morality in the mundane: specific needs for ethics support in elderly care.
PG  - 91-103
LID - 10.1177/0969733011412102 [doi]
AB  - Ethics support is called for to improve the quality of care in elderly
      institutions. Various forms of ethics support are presented, but the needs for
      ethics support remain unknown. Using a mixed-methods design, this article
      systematically investigates the specific needs for ethics support in elderly
      care. The findings of two surveys, two focus groups and 17 interviews demonstrate
      that the availability of ethics support is limited. There is a need for ethics
      support, albeit not unconditionally. Advice-based forms of ethics support are
      less appropriate as they are removed from practice. Ethics support should be
      tailored to the often mundane and easily overlooked moral issues that arise in
      long-term care. Attention should also be given to the learning styles of nurses
      who favour experiential learning. Raising awareness and developing a climate of
      openness and dialogue are the most suitable ways to deal with the mundane moral
      issues in elderly care.
FAU - Dauwerse, Linda
AU  - Dauwerse L
AD  - VU Medisch Centrum, Van der Boechorststraat 7, Amsterdam, The Netherlands.
      l.dauwerse@vumc.nl
FAU - van der Dam, Sandra
AU  - van der Dam S
FAU - Abma, Tineke
AU  - Abma T
LA  - eng
PT  - Journal Article
DEP - 20111202
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Aged
MH  - *Ethics Consultation
MH  - Geriatric Nursing/*ethics
MH  - Humans
MH  - *Morals
MH  - *Needs Assessment
MH  - Netherlands
MH  - Nursing Evaluation Research
MH  - Qualitative Research
EDAT- 2011/12/06 06:00
MHDA- 2012/05/11 06:00
CRDT- 2011/12/06 06:00
PHST- 2011/12/06 06:00 [entrez]
PHST- 2011/12/06 06:00 [pubmed]
PHST- 2012/05/11 06:00 [medline]
AID - 0969733011412102 [pii]
AID - 10.1177/0969733011412102 [doi]
PST - ppublish
SO  - Nurs Ethics. 2012 Jan;19(1):91-103. doi: 10.1177/0969733011412102. Epub 2011 Dec 
      2.


PMID- 22140179
OWN - NLM
STAT- MEDLINE
DCOM- 20130107
LR  - 20220408
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 19
IP  - 5
DP  - 2012 Sep
TI  - Ethical problems: In the face of sudden and unexpected death.
PG  - 642-53
AB  - When people die suddenly and unexpectedly ethical issues often come to the fore. 
      The aim of the study was to describe experiences of members of stroke teams in
      stroke units of ethical problems and how the teams manage the situation when
      caring for patients faced with sudden and unexpected death from stroke. Data were
      collected through four focus group interviews with 19 team members in stroke-unit
      teams, and analysed using interpretive content analysis. Three themes emerged
      from the analysis characterized by information, decisions about care and support 
      for the next-of-kin in the changing and uncertain situation, with mutual trust as
      the core. Mutual trust, both within the stroke team and with next-of-kin was seen
      by the stroke-team members as a way of handling ethical problems by administering
      care with the patient's best interest at heart.
FAU - Rejno, Asa
AU  - Rejno A
AD  - Gothenburg University, Sweden; Skaraborg Hospital, Sweden. asa.rejno@vgregion.se
FAU - Berg, Linda
AU  - Berg L
FAU - Danielson, Ella
AU  - Danielson E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111202
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - *Death, Sudden
MH  - Decision Making
MH  - *Ethics, Nursing
MH  - Family Relations
MH  - Focus Groups
MH  - Hospital Units
MH  - Humans
MH  - Interviews as Topic
MH  - Patient Care Team/*ethics
MH  - Social Facilitation
MH  - Stroke/*therapy
MH  - Trust
EDAT- 2011/12/06 06:00
MHDA- 2013/01/08 06:00
CRDT- 2011/12/06 06:00
PHST- 2011/12/06 06:00 [entrez]
PHST- 2011/12/06 06:00 [pubmed]
PHST- 2013/01/08 06:00 [medline]
AID - 0969733011412099 [pii]
AID - 10.1177/0969733011412099 [doi]
PST - ppublish
SO  - Nurs Ethics. 2012 Sep;19(5):642-53. doi: 10.1177/0969733011412099. Epub 2011 Dec 
      2.


PMID- 22139879
OWN - NLM
STAT- MEDLINE
DCOM- 20120418
LR  - 20181201
IS  - 1439-7803 (Electronic)
IS  - 0044-2771 (Linking)
VI  - 49
IP  - 12
DP  - 2011 Jul
TI  - [Lack of data relevant for German transplantation medicine].
PG  - 1549-52
LID - 10.1055/s-0031-1281737 [doi]
AB  - Collection of data in transplantation medicine is required to define ethical
      standards, to assess indications and contra-indications and to determine rules
      for organ allocation. Similarly, assessment of quality of the transplantation
      process and practice of transplantation centres requires relevant data in
      transplantation medicine. Apart from data in quality reports, Eurotransplant and 
      organ procurement, any form of data collection is lacking in Germany. In this
      article the problems caused by this shortcoming are described.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Otto, G
AU  - Otto G
AD  - Abteilung fur Transplantationschirurgie der Universitatsmedizin,
      Johannes-Gutenberg-Universitat Mainz. otto@transplantation.klinik.unimainz.de
FAU - Lohse, A W
AU  - Lohse AW
LA  - ger
PT  - Journal Article
TT  - Defizite bei der Erfassung transplantationsrelevanter Daten in Deutschland.
DEP - 20111202
PL  - Germany
TA  - Z Gastroenterol
JT  - Zeitschrift fur Gastroenterologie
JID - 0033370
SB  - IM
MH  - Databases, Factual/*statistics & numerical data
MH  - Germany/epidemiology
MH  - Humans
MH  - *Mandatory Reporting
MH  - Organ Transplantation/*statistics & numerical data
MH  - Registries/*statistics & numerical data
EDAT- 2011/12/06 06:00
MHDA- 2012/04/19 06:00
CRDT- 2011/12/06 06:00
PHST- 2011/12/06 06:00 [entrez]
PHST- 2011/12/06 06:00 [pubmed]
PHST- 2012/04/19 06:00 [medline]
AID - 10.1055/s-0031-1281737 [doi]
PST - ppublish
SO  - Z Gastroenterol. 2011 Jul;49(12):1549-52. doi: 10.1055/s-0031-1281737. Epub 2011 
      Dec 2.


PMID- 22139783
OWN - NLM
STAT- MEDLINE
DCOM- 20120406
LR  - 20131121
IS  - 1522-1229 (Electronic)
IS  - 1043-4046 (Linking)
VI  - 35
IP  - 4
DP  - 2011 Dec
TI  - A double-blind atropine trial for active learning of autonomic function.
PG  - 438-44
LID - 10.1152/advan.00075.2011 [doi]
AB  - Here, we describe a human physiology laboratory class measuring changes in
      autonomic function over time in response to atropine. Students use themselves as 
      subjects, generating ownership and self-interest in the learning as well as
      directly experiencing the active link between physiology and pharmacology in
      people. The class is designed to concomitantly convey the importance of bias in
      experimentation by adopting a double-blind placebo-controlled approach. We have
      used this class effectively in various forms with approximately 600 students
      receiving atropine over the last 16 yr. This class has received favorable
      feedback from staff and students of medicine, pharmacy, and neuroscience, and we 
      recommend it for such undergraduates. The learning objectives that students are
      expected to achieve are to be able to 1) know the ethical, safety, and hygiene
      requirements for using human volunteers as subjects; 2) implement and explain a
      double-blind placebo-controlled trial; 3) design, agree, and execute a protocol
      for making (and accurately recording) precise reproducible measurements of pulse 
      rate, pupil diameter, and salivary flow; 4) evaluate the importance of predose
      periods and measurement consistency to detect effects (including any
      reversibility) after an intervention; 5) experience direct cause-and-effect
      relationships integrating physiology with pharmacology in people; 6) calculate
      appropriate summary statistics to describe the data and determine the data's
      statistical significance; 7) recognize normal variability both within and between
      subjects in baseline physiological parameters and also recognize normal
      variability in response to pharmacological treatment; 8) infer the distribution
      and role of muscarinic receptors in the autonomic nervous system with respect to 
      the heart, eye, and mouth; 9) identify and explain the clinical significance of
      differences in effect due to the route and formulation of atropine; 10) produce
      and deliver a concise oral presentation of experimental findings; and 11) produce
      a written report in the form of a short scientific research article. The results 
      of a typical study are presented, which demonstrate that the administration of
      atropine by a subcutaneous injection elicited a significant increase in pulse
      rate and pupil diameter and a significant decrease in salivary flow, whereas
      administration of atropine in an oral liquid elicited significant effects on
      pulse rate and salivary flow, and an oral solid format elicited a significant
      alteration in salivary flow alone. More detailed analysis of the salivary flow
      data demonstrated clear differences between the routes of administration and
      formulation in the onset and magnitude of action of atropine.
FAU - Fry, Jeffrey R
AU  - Fry JR
AD  - School of Biomedical Sciences, Faculty of Medicine and Health Sciences,
      University of Nottingham, United Kingdom.
FAU - Burr, Steven A
AU  - Burr SA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Adv Physiol Educ
JT  - Advances in physiology education
JID - 100913944
RN  - 0 (Muscarinic Antagonists)
RN  - 0 (Placebos)
RN  - 7C0697DR9I (Atropine)
SB  - IM
MH  - Atropine/administration & dosage/*pharmacology
MH  - Autonomic Nervous System/*drug effects/physiology
MH  - Biomedical Research/*education
MH  - Comprehension
MH  - Double-Blind Method
MH  - England
MH  - Feedback
MH  - Heart Rate/drug effects
MH  - Humans
MH  - Learning
MH  - Muscarinic Antagonists/administration & dosage/*pharmacology
MH  - Physiology/*education
MH  - Placebos
MH  - *Problem-Based Learning
MH  - Pupil/drug effects
MH  - *Randomized Controlled Trials as Topic
MH  - Salivation/drug effects
MH  - Teaching/*methods
MH  - Time Factors
EDAT- 2011/12/06 06:00
MHDA- 2012/04/07 06:00
CRDT- 2011/12/06 06:00
PHST- 2011/12/06 06:00 [entrez]
PHST- 2011/12/06 06:00 [pubmed]
PHST- 2012/04/07 06:00 [medline]
AID - 35/4/438 [pii]
AID - 10.1152/advan.00075.2011 [doi]
PST - ppublish
SO  - Adv Physiol Educ. 2011 Dec;35(4):438-44. doi: 10.1152/advan.00075.2011.


PMID- 22139737
OWN - NLM
STAT- MEDLINE
DCOM- 20120117
LR  - 20161020
IS  - 0256-2855 (Print)
IS  - 0256-2855 (Linking)
VI  - 121
IP  - 11
DP  - 2011
TI  - The effect of Parodontax(R) on the MMP-8 concentration in gingivitis patients.
PG  - 1041-51
AB  - The aim of the study was to evaluate the efficacy of Parodontax(R)
      (GlaxoSmith-Kline, Buhl, Germany) on the signs gingival inflammation and the
      enzyme activity of matrix metalloproteinase-8 (aMMP-8) in the gingival crevicular
      fluid. After approval by the ethics commission, a total of 50 volunteers
      participated in the study; group 1 (n = 25, age: 43 +/- 12 years) with moderate
      gingivitis (BOP +) and group 2 (n = 25, age: 29 +/- 11 years) with clinically
      healthy gingival conditions (BOP -). After obtaining anamnestic data, the dental 
      examination included assessment of oral hygiene (Quigley & Hein 1962), gingival
      inflammation (Saxer & Muhlemann 1975), probing pocket depth and clinical
      attachment level. Gingival crevicular fluid was collected from both groups. A
      quantitative assessment of aMMP-8 in the gingival crevicular fluid samples was
      performed (DentoAnalyzer, Dentognostics GmbH, Jena, Germany). Study participants 
      were instructed to use only Parodontax(R). After three weeks, all parameters were
      measured again. The aMMP-8 values of group 1 were significantly reduced after the
      use of Parodontax(R) toothpaste and mouthwash (p < 0.001; baseline median 41.25
      +/- 38.16 ng/ml, final post-treatment median 7.73 +/- 7.58 ng/ml aMMP-8 eluate;
      group 2: baseline median 3.75 +/- 3.16 ng/ml, final post-treatment median 3.73
      +/- 1.54 ng/ml aMMP-8 eluate). Gingival inflammation and plaque accumulation were
      reduced. It was shown that Parodontax(R) was effective in reducing the enzymatic 
      activity of inflammation.
FAU - Ehlers, Vicky
AU  - Ehlers V
AD  - Clinic for Restorative Dentistry University Medical School, Johannes Gutenberg
      University, Mainz, Germany. vicky.ehlers@unimedizin-mainz.de
FAU - Helm, Sebastian
AU  - Helm S
FAU - Kasaj, Adrian
AU  - Kasaj A
FAU - Willershausen, Brita
AU  - Willershausen B
LA  - eng
LA  - ger
PT  - Clinical Trial
PT  - Journal Article
PL  - Switzerland
TA  - Schweiz Monatsschr Zahnmed
JT  - Schweizer Monatsschrift fur Zahnmedizin = Revue mensuelle suisse
      d'odonto-stomatologie = Rivista mensile svizzera di odontologia e stomatologia
JID - 8709597
RN  - 0 (Mouthwashes)
RN  - 0 (Parodontax)
RN  - 0 (Plant Extracts)
RN  - 0 (Plant Preparations)
RN  - 8MDF5V39QO (Sodium Bicarbonate)
RN  - EC 3.4.24.34 (Matrix Metalloproteinase 8)
SB  - IM
MH  - Adult
MH  - Dental Plaque/prevention & control
MH  - Female
MH  - Gingival Crevicular Fluid/*enzymology
MH  - Gingivitis/*drug therapy/*enzymology
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 8/analysis/*metabolism
MH  - Middle Aged
MH  - Mouthwashes/*therapeutic use
MH  - *Phytotherapy
MH  - Plant Extracts/therapeutic use
MH  - Plant Preparations/therapeutic use
MH  - Sodium Bicarbonate/*therapeutic use
MH  - Young Adult
EDAT- 2011/12/06 06:00
MHDA- 2012/01/18 06:00
CRDT- 2011/12/06 06:00
PHST- 2011/02/08 00:00 [accepted]
PHST- 2011/12/06 06:00 [entrez]
PHST- 2011/12/06 06:00 [pubmed]
PHST- 2012/01/18 06:00 [medline]
AID - smfz-2011-11-04 [pii]
PST - ppublish
SO  - Schweiz Monatsschr Zahnmed. 2011;121(11):1041-51.


PMID- 22139103
OWN - NLM
STAT- MEDLINE
DCOM- 20121019
LR  - 20181201
IS  - 0807-7096 (Electronic)
IS  - 0029-2001 (Linking)
VI  - 131
IP  - 23
DP  - 2011 Nov 29
TI  - [Ethics and reproductive health].
PG  - 2334-5
LID - 10.4045/tidsskr.11.1109 [doi]
FAU - Roger, Magnus
AU  - Roger M
FAU - Bleken, Hakon
AU  - Bleken H
LA  - nor
PT  - Letter
PT  - Comment
TT  - Etikk og reproduktiv helse.
PL  - Norway
TA  - Tidsskr Nor Laegeforen
JT  - Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny
      raekke
JID - 0413423
SB  - IM
CON - Tidsskr Nor Laegeforen. 2011 Oct 4;131(19):1907-9. PMID: 21984300
CIN - Tidsskr Nor Laegeforen. 2012 Jan 10;132(1):10. PMID: 22240814
MH  - *Global Health
MH  - *Goals
MH  - Humans
MH  - *Reproductive Medicine
EDAT- 2011/12/06 06:00
MHDA- 2012/10/20 06:00
CRDT- 2011/12/06 06:00
PHST- 2011/12/06 06:00 [entrez]
PHST- 2011/12/06 06:00 [pubmed]
PHST- 2012/10/20 06:00 [medline]
AID - 2175538 [pii]
AID - 10.4045/tidsskr.11.1109 [doi]
PST - ppublish
SO  - Tidsskr Nor Laegeforen. 2011 Nov 29;131(23):2334-5. doi: 10.4045/tidsskr.11.1109.


PMID- 22138728
OWN - NLM
STAT- MEDLINE
DCOM- 20120524
LR  - 20120322
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 4
DP  - 2012 Apr
TI  - Threats and offers in community mental healthcare.
PG  - 204-9
LID - 10.1136/medethics-2011-100158 [doi]
AB  - Making threats and offers to patients is a strategy used in community mental
      healthcare to increase treatment adherence. In this paper, an ethical analysis of
      these types of proposal is presented. It is argued (1) that the primary ethical
      consideration is to identify the professional duties of care held by those
      working in community mental health because the nature of these duties will enable
      a threat to be differentiated from an offer, (2) that threatening to act in a way
      that would equate with a failure to uphold the requirements of these duties is
      wrong, irrespective of the benefit accrued through treatment adherence and (3)
      that making offers to patients raises a number of secondary ethical
      considerations that need to be judged on their own merit in the context of
      individual patient care. The paper concludes by considering the implications of
      these arguments, setting out a pathway designed to assist community mental
      healthcare practitioners to determine whether making a specific proposal to a
      patient is right or wrong.
FAU - Dunn, Michael
AU  - Dunn M
AD  - The Ethox Centre, University of Oxford, Old Road Campus, Headington, Oxford OX3
      7LF, UK. michael.dunn@ethox.ox.ac.uk
FAU - Maughan, Daniel
AU  - Maughan D
FAU - Hope, Tony
AU  - Hope T
FAU - Canvin, Krysia
AU  - Canvin K
FAU - Rugkasa, Jorun
AU  - Rugkasa J
FAU - Sinclair, Julia
AU  - Sinclair J
FAU - Burns, Tom
AU  - Burns T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111202
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
CIN - J Med Ethics. 2012 Apr;38(4):194. PMID: 22438578
MH  - Community Mental Health Services/*ethics/*methods
MH  - Decision Making
MH  - Human Rights
MH  - Humans
MH  - Patient Compliance
MH  - Persuasive Communication
MH  - Treatment Refusal/*ethics
EDAT- 2011/12/06 06:00
MHDA- 2012/05/25 06:00
CRDT- 2011/12/06 06:00
PHST- 2011/12/06 06:00 [entrez]
PHST- 2011/12/06 06:00 [pubmed]
PHST- 2012/05/25 06:00 [medline]
AID - medethics-2011-100158 [pii]
AID - 10.1136/medethics-2011-100158 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Apr;38(4):204-9. doi: 10.1136/medethics-2011-100158. Epub 2011
      Dec 2.


PMID- 22138180
OWN - NLM
STAT- MEDLINE
DCOM- 20120612
LR  - 20171114
IS  - 1468-330X (Electronic)
IS  - 0022-3050 (Linking)
VI  - 83
IP  - 5
DP  - 2012 May
TI  - Pain perception in humans: use of intraepidermal electrical stimulation.
PG  - 551-6
LID - 10.1136/jnnp-2011-301484 [doi]
AB  - The choice of a system specific stimulus is difficult when investigating the
      human nociceptive system, in contrast with the tactile, auditory and visual
      systems, because it should be noxious but not actually damage the tissue. The
      discomfort accompanying system specific stimulation must be kept to a minimum for
      ethical reasons. In this review, recent progress made in the study of human pain 
      perception using intraepidermal electrical stimulation (IES) is described. Also, 
      whether IES is a viable alternative to laser stimulation is discussed. IES
      selectively activates Adelta nociceptors, elicits a sharp pricking sensation with
      minimal discomfort and evokes cortical responses almost identical to those
      produced by laser stimulation. As IES does not require expensive equipment, and
      is easy to control, it would seem useful for pain research as well as clinical
      tests.
FAU - Inui, Koji
AU  - Inui K
AD  - Integrative Physiology, National Institute for Physiological Sciences, Okazaki,
      Aichi, Japan. inui@nips.ac.jp
FAU - Kakigi, Ryusuke
AU  - Kakigi R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111203
PL  - England
TA  - J Neurol Neurosurg Psychiatry
JT  - Journal of neurology, neurosurgery, and psychiatry
JID - 2985191R
SB  - IM
MH  - Cerebral Cortex/physiology
MH  - Electric Stimulation/*methods
MH  - Epidermis/*physiology/radiation effects
MH  - Humans
MH  - Lasers
MH  - Nociceptors/physiology
MH  - Pain Measurement/*methods
MH  - Pain Perception/*physiology
EDAT- 2011/12/06 06:00
MHDA- 2012/06/13 06:00
CRDT- 2011/12/06 06:00
PHST- 2011/12/06 06:00 [entrez]
PHST- 2011/12/06 06:00 [pubmed]
PHST- 2012/06/13 06:00 [medline]
AID - jnnp-2011-301484 [pii]
AID - 10.1136/jnnp-2011-301484 [doi]
PST - ppublish
SO  - J Neurol Neurosurg Psychiatry. 2012 May;83(5):551-6. doi:
      10.1136/jnnp-2011-301484. Epub 2011 Dec 3.


PMID- 22137775
OWN - NLM
STAT- MEDLINE
DCOM- 20120615
LR  - 20220321
IS  - 1778-3585 (Electronic)
IS  - 0924-9338 (Linking)
VI  - 27
IP  - 2
DP  - 2012 Feb
TI  - The European Psychiatric Association (EPA) guidance on suicide treatment and
      prevention.
PG  - 129-41
LID - 10.1016/j.eurpsy.2011.06.003 [doi]
AB  - UNLABELLED: Suicide is a major public health problem in the WHO European Region
      accounting for over 150,000 deaths per year. SUICIDAL CRISIS: Acute intervention 
      should start immediately in order to keep the patient alive. DIAGNOSIS: An
      underlying psychiatric disorder is present in up to 90% of people who completed
      suicide. Comorbidity with depression, anxiety, substance abuse and personality
      disorders is high. In order to achieve successful prevention of suicidality,
      adequate diagnostic procedures and appropriate treatment for the underlying
      disorder are essential. TREATMENT: Existing evidence supports the efficacy of
      pharmacological treatment and cognitive behavioural therapy (CBT) in preventing
      suicidal behaviour. Some other psychological treatments are promising, but the
      supporting evidence is currently insufficient. Studies show that antidepressant
      treatment decreases the risk for suicidality among depressed patients. However,
      the risk of suicidal behaviour in depressed patients treated with antidepressants
      exists during the first 10-14 days of treatment, which requires careful
      monitoring. Short-term supplementary medication with anxiolytics and hypnotics in
      the case of anxiety and insomnia is recommended. Treatment with antidepressants
      of children and adolescents should only be given under supervision of a
      specialist. Long-term treatment with lithium has been shown to be effective in
      preventing both suicide and attempted suicide in patients with unipolar and
      bipolar depression. Treatment with clozapine is effective in reducing suicidal
      behaviour in patients with schizophrenia. Other atypical antipsychotics are
      promising but more evidence is required. TREATMENT TEAM: Multidisciplinary
      treatment teams including psychiatrist and other professionals such as
      psychologist, social worker, and occupational therapist are always preferable, as
      integration of pharmacological, psychological and social rehabilitation is
      recommended especially for patients with chronic suicidality. FAMILY: The
      suicidal person independently of age should always be motivated to involve family
      in the treatment. SOCIAL SUPPORT: Psychosocial treatment and support is
      recommended, as the majority of suicidal patients have problems with
      relationships, work, school and lack functioning social networks. SAFETY: A
      secure home, public and hospital environment, without access to suicidal means is
      a necessary strategy in suicide prevention. Each treatment option, prescription
      of medication and discharge of the patient from hospital should be carefully
      evaluated against the involved risks. TRAINING OF PERSONNEL: Training of general 
      practitioners (GPs) is effective in the prevention of suicide. It improves
      treatment of depression and anxiety, quality of the provided care and attitudes
      towards suicide. Continuous training including discussions about ethical and
      legal issues is necessary for psychiatrists and other mental health
      professionals.
CI  - Copyright (c) 2011 Elsevier Masson SAS. All rights reserved.
FAU - Wasserman, D
AU  - Wasserman D
AD  - The National Centre for Suicide Research and Prevention of Mental Ill-Health
      (NASP), Karolinska Institutet, Stockholm, Sweden. danuta.wasserman@ki.se
FAU - Rihmer, Z
AU  - Rihmer Z
FAU - Rujescu, D
AU  - Rujescu D
FAU - Sarchiapone, M
AU  - Sarchiapone M
FAU - Sokolowski, M
AU  - Sokolowski M
FAU - Titelman, D
AU  - Titelman D
FAU - Zalsman, G
AU  - Zalsman G
FAU - Zemishlany, Z
AU  - Zemishlany Z
FAU - Carli, V
AU  - Carli V
CN  - European Psychiatric Association
LA  - eng
PT  - Journal Article
PT  - Practice Guideline
DEP - 20111201
PL  - England
TA  - Eur Psychiatry
JT  - European psychiatry : the journal of the Association of European Psychiatrists
JID - 9111820
RN  - 0 (Antidepressive Agents)
RN  - 0 (Antipsychotic Agents)
SB  - IM
MH  - Antidepressive Agents/therapeutic use
MH  - Antipsychotic Agents/therapeutic use
MH  - Bipolar Disorder/*drug therapy
MH  - Depressive Disorder/*drug therapy
MH  - Humans
MH  - Schizophrenia/*drug therapy
MH  - Suicidal Ideation
MH  - Suicide/*prevention & control/psychology
EDAT- 2011/12/06 06:00
MHDA- 2012/06/16 06:00
CRDT- 2011/12/06 06:00
PHST- 2011/04/11 00:00 [received]
PHST- 2011/06/07 00:00 [revised]
PHST- 2011/06/13 00:00 [accepted]
PHST- 2011/12/06 06:00 [entrez]
PHST- 2011/12/06 06:00 [pubmed]
PHST- 2012/06/16 06:00 [medline]
AID - S0924-9338(11)00108-8 [pii]
AID - 10.1016/j.eurpsy.2011.06.003 [doi]
PST - ppublish
SO  - Eur Psychiatry. 2012 Feb;27(2):129-41. doi: 10.1016/j.eurpsy.2011.06.003. Epub
      2011 Dec 1.


PMID- 22137424
OWN - NLM
STAT- MEDLINE
DCOM- 20120405
LR  - 20111205
IS  - 1873-6513 (Electronic)
IS  - 0885-3924 (Linking)
VI  - 42
IP  - 6
DP  - 2011 Dec
TI  - Denying a patient's final will: public safety vs. medical confidentiality and
      patient autonomy.
PG  - 961-6
LID - 10.1016/j.jpainsymman.2011.08.004 [doi]
AB  - Especially when caring for patients approaching the end of life, physicians and
      nursing staff feel committed to fulfilling as many patient desires as possible.
      However, sometimes a patient's "final will" may threaten public safety. This can 
      lead to severe conflicts, outweighing the physician's obligation and dedication
      to care for the patient and to respect his autonomy. Yet, public safety can be
      threatened if confidentiality is not broken. This article provides a concise
      summary of the medicolegal and ethical fundamentals concerning this difficult
      situation. If the patient's and others' health and safety are at risk, physicians
      may (and in some countries must) break medical confidentiality and disclose
      confidential patient information to the police and other authorities. Physicians 
      should be able to professionally deal with such a conflict in all patients, not
      only in patients with advanced illness.
CI  - Copyright (c) 2011 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. 
      All rights reserved.
FAU - Gaertner, Jan
AU  - Gaertner J
AD  - Department of Palliative Medicine, University Hospital, Cologne, Germany.
      jan.gaertner@uk-koeln.de
FAU - Vent, Julia
AU  - Vent J
FAU - Greinwald, Ralf
AU  - Greinwald R
FAU - Rothschild, Markus A
AU  - Rothschild MA
FAU - Ostgathe, Christoph
AU  - Ostgathe C
FAU - Kessel, Rene
AU  - Kessel R
FAU - Voltz, Raymond
AU  - Voltz R
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Pain Symptom Manage
JT  - Journal of pain and symptom management
JID - 8605836
RN  - 0 (Analgesics, Opioid)
SB  - IM
MH  - Analgesics, Opioid/adverse effects
MH  - Automobile Driving/*legislation & jurisprudence
MH  - Brain Neoplasms/psychology
MH  - Carcinoma, Basal Cell/psychology
MH  - Confidentiality/*ethics/*legislation & jurisprudence
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Palliative Care/ethics/*legislation & jurisprudence
MH  - *Personal Autonomy
MH  - Physician-Patient Relations
MH  - Psychomotor Performance/drug effects
MH  - *Safety
EDAT- 2011/12/06 06:00
MHDA- 2012/04/06 06:00
CRDT- 2011/12/06 06:00
PHST- 2011/04/18 00:00 [received]
PHST- 2011/08/09 00:00 [revised]
PHST- 2011/08/13 00:00 [accepted]
PHST- 2011/12/06 06:00 [entrez]
PHST- 2011/12/06 06:00 [pubmed]
PHST- 2012/04/06 06:00 [medline]
AID - S0885-3924(11)00511-2 [pii]
AID - 10.1016/j.jpainsymman.2011.08.004 [doi]
PST - ppublish
SO  - J Pain Symptom Manage. 2011 Dec;42(6):961-6. doi:
      10.1016/j.jpainsymman.2011.08.004.


PMID- 22137306
OWN - NLM
STAT- MEDLINE
DCOM- 20120403
LR  - 20121003
IS  - 1097-6809 (Electronic)
IS  - 0741-5214 (Linking)
VI  - 54
IP  - 6
DP  - 2011 Dec
TI  - How informed need be informed consent?
PG  - 1830-1
LID - 10.1016/j.jvs.2011.10.020 [doi]
AB  - Dr C. Lever is a pioneer in endovascular infrarenal aneurysmectomy, with some of 
      the best results published in the literature. He attempted an endovascular stent 
      in an octogenarian that required an acute open repair. The procedure was
      touch-and-go and the postoperative course a train wreck, with multiple organ
      dysfunction syndrome. After steadily deteriorating, the patient died. The son has
      filed a lawsuit claiming Dr Lever did not specify that a standard procedure might
      need to be done as an emergency. Dr Lever usually indicates an open procedure
      might be necessary, but the resident did not include whether or not Dr Lever did 
      so in the informed consent note. Regarding technical details in the informed
      consent note: A. Always include operative details that will increase the risk, no
      matter how rare. B. Operative details are not necessary. C. Complications are the
      only necessary important components of informed consent documentation. D. As long
      as you postoperatively document what happened in the OR, you are legally and
      ethically all right. E. Every factor that could influence the patient's decision 
      must be mentioned and then adequately documented.
CI  - Copyright (c) 2011 Society for Vascular Surgery. Published by Mosby, Inc. All
      rights reserved.
FAU - Jones, James W
AU  - Jones JW
AD  - Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston,
      Tex., USA. jwjones@bcm.tmc.edu
FAU - McCullough, Laurence B
AU  - McCullough LB
LA  - eng
PT  - Case Reports
PT  - Editorial
PL  - United States
TA  - J Vasc Surg
JT  - Journal of vascular surgery
JID - 8407742
SB  - IM
MH  - Aged, 80 and over
MH  - Humans
MH  - Informed Consent/*ethics/*legislation & jurisprudence
MH  - Male
MH  - Vascular Surgical Procedures/*adverse effects/ethics/legislation & jurisprudence
EDAT- 2011/12/06 06:00
MHDA- 2012/04/04 06:00
CRDT- 2011/12/06 06:00
PHST- 2011/12/06 06:00 [entrez]
PHST- 2011/12/06 06:00 [pubmed]
PHST- 2012/04/04 06:00 [medline]
AID - S0741-5214(11)02338-X [pii]
AID - 10.1016/j.jvs.2011.10.020 [doi]
PST - ppublish
SO  - J Vasc Surg. 2011 Dec;54(6):1830-1. doi: 10.1016/j.jvs.2011.10.020.


PMID- 22137288
OWN - NLM
STAT- MEDLINE
DCOM- 20130418
LR  - 20161209
IS  - 2213-0276 (Electronic)
IS  - 0755-4982 (Linking)
VI  - 41
IP  - 6 Pt 1
DP  - 2012 Jun
TI  - [Nutritional management in amyotrophic lateral sclerosis: A medical and ethical
      stake].
PG  - 560-74
LID - 10.1016/j.lpm.2011.09.024 [doi]
AB  - Malnutrition and dehydration are common and result from swallowing disorders
      secondary to degeneration of brainstem motor neurons. Recent knowledge argues in 
      favor of the associated primary metabolism abnormalities. Though muscle atrophy, 
      a paradoxical hypermetabolism at rest has often been observed. Hyperlipidemia and
      glucose intolerance are more frequent than in general population. The
      heterogeneity of the nutritional assessment of patients in published series is
      due, partially at least, to the use of disparate criteria and evaluating
      procedures. Weight lost is an independent negative survival prognostic factor.
      Overweight may be beneficial for the survival of ALS patients. A specific
      nutritional management for ALS is an essential point in the multidisciplinary
      support. The criteria leading to artificial nutrition indication are medical,
      mainly based on percentage of weight loss, but also psychological and ethical.
CI  - Copyright (c) 2011 Elsevier Masson SAS. All rights reserved.
FAU - Lehericey, Guillaume
AU  - Lehericey G
AD  - AP-HP, groupe hospitalier Pitie-Salpetriere, service de dietetique, 75651 Paris
      cedex 13, France.
FAU - Le Forestier, Nadine
AU  - Le Forestier N
FAU - Dupuis, Luc
AU  - Dupuis L
FAU - Gonzalez-Bermejo, Jesus
AU  - Gonzalez-Bermejo J
FAU - Meininger, Vincent
AU  - Meininger V
FAU - Pradat, Pierre-Francois
AU  - Pradat PF
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Prise en charge nutritionnelle dans la sclerose laterale amyotrophique : un enjeu
      medical et ethique.
DEP - 20111201
PL  - France
TA  - Presse Med
JT  - Presse medicale (Paris, France : 1983)
JID - 8302490
SB  - IM
MH  - Amyotrophic Lateral Sclerosis/complications/*diet therapy/metabolism
MH  - Deglutition Disorders/complications/*diet therapy
MH  - Humans
MH  - Malnutrition/complications/*diet therapy
MH  - Nutrition Assessment
MH  - Nutritional Status
EDAT- 2011/12/06 06:00
MHDA- 2013/04/20 06:00
CRDT- 2011/12/06 06:00
PHST- 2011/06/01 00:00 [received]
PHST- 2011/08/12 00:00 [revised]
PHST- 2011/09/08 00:00 [accepted]
PHST- 2011/12/06 06:00 [entrez]
PHST- 2011/12/06 06:00 [pubmed]
PHST- 2013/04/20 06:00 [medline]
AID - S0755-4982(11)00553-7 [pii]
AID - 10.1016/j.lpm.2011.09.024 [doi]
PST - ppublish
SO  - Presse Med. 2012 Jun;41(6 Pt 1):560-74. doi: 10.1016/j.lpm.2011.09.024. Epub 2011
      Dec 1.


PMID- 22137201
OWN - NLM
STAT- MEDLINE
DCOM- 20120727
LR  - 20191210
IS  - 1887-1364 (Electronic)
IS  - 1134-282X (Linking)
VI  - 27
IP  - 2
DP  - 2012 Mar-Apr
TI  - [Patients' perspective and economic variables as objectives in clinical trials:
      added value to clinical parameters].
PG  - 92-102
LID - 10.1016/j.cali.2011.09.007 [doi]
AB  - OBJECTIVE: Patient-reported outcome (PRO) measures complement traditional
      biomedical outcome measures. The purpose of this study was to evaluate the use of
      PRO measures including health-related quality of life (HRQoL) questionnaires as a
      measurement of efficacy and the frequency of inclusion of economic variables
      related to direct and indirect costs in the design of clinical trials and phase
      IV observational studies. Moreover, for the trials quality score were measured,
      and if there were any relationship between the quality study design score and the
      PRO inclusion. MATERIAL AND METHODS: Retrospective observational study of the
      clinical trials and phase IV observational studies approved by a Clinical
      Research Ethics Committee (2008-2010). We gathered data concerning general
      aspects including medical specialty, pathology, methodological quality based on
      Jadad scale (0-5), inclusion of PRO and economic variables. For clinical trials
      including HRQoL measurements, we analysed the type of questionnaire in use. Where
      there were no HRQoL measurements, we analysed if their inclusion would have been 
      proper or not. RESULTS: A total of 70 protocols (59 CTs and 11 phase IV
      observational studies) were analysed; 37 (52.8%) included PRO measures, and 3
      protocols (4.3%) used them as a primary endpoint. Data analysis by therapeutic
      area showed that PRO measures were most commonly studied in the fields of
      endocrinology, neurology, digestive diseases, and cardiology. The average quality
      score for the trials was 2.8. The trials with more PRO inclusion in their end
      points had a significantly higher quality score. Only 13 (22%) clinical trials
      and 2 (18.2%) phase IV observational studies included economic variables.
      CONCLUSIONS: The emergence of economic variables in clinical trials and phase IV 
      observational studies evaluated was low, however, more than half of the revised
      protocols have included PRO measures, reflecting the importance of these
      parameters in the assessment of the effectiveness of drug treatments, although
      its use is still not systematic.
CI  - Copyright (c) 2011 SECA. Published by Elsevier Espana. All rights reserved.
FAU - Bovaira-Garcia, M J
AU  - Bovaira-Garcia MJ
AD  - Servicio de Farmacia, Consorcio Hospitalario Provincial de Castellon, Castellon, 
      Espana.
FAU - Soler-Company, E
AU  - Soler-Company E
LA  - spa
PT  - Journal Article
TT  - Perspectiva de los pacientes y variables economicas como objetivo en los ensayos 
      clinicos, valores anadidos a los parametros clinicos.
DEP - 20111201
PL  - Spain
TA  - Rev Calid Asist
JT  - Revista de calidad asistencial : organo de la Sociedad Espanola de Calidad
      Asistencial
JID - 9601664
SB  - IM
MH  - Clinical Trials as Topic/economics/*statistics & numerical data
MH  - Clinical Trials, Phase IV as Topic/economics/statistics & numerical data
MH  - *Cost of Illness
MH  - Drug Therapy/economics/psychology
MH  - Health Expenditures
MH  - Humans
MH  - Medicine
MH  - Multicenter Studies as Topic/economics/statistics & numerical data
MH  - Outcome Assessment, Health Care/*methods
MH  - Patient Satisfaction
MH  - Patients/*psychology
MH  - Quality of Life
MH  - Randomized Controlled Trials as Topic/economics/statistics & numerical data
MH  - Surveys and Questionnaires
EDAT- 2011/12/06 06:00
MHDA- 2012/07/28 06:00
CRDT- 2011/12/06 06:00
PHST- 2011/02/15 00:00 [received]
PHST- 2011/08/31 00:00 [revised]
PHST- 2011/09/03 00:00 [accepted]
PHST- 2011/12/06 06:00 [entrez]
PHST- 2011/12/06 06:00 [pubmed]
PHST- 2012/07/28 06:00 [medline]
AID - S1134-282X(11)00171-0 [pii]
AID - 10.1016/j.cali.2011.09.007 [doi]
PST - ppublish
SO  - Rev Calid Asist. 2012 Mar-Apr;27(2):92-102. doi: 10.1016/j.cali.2011.09.007. Epub
      2011 Dec 1.


PMID- 22137044
OWN - NLM
STAT- MEDLINE
DCOM- 20120409
LR  - 20151119
IS  - 1873-5118 (Electronic)
IS  - 0301-0082 (Linking)
VI  - 95
IP  - 4
DP  - 2011 Dec
TI  - Ethical considerations of biomarker use in neurodegenerative diseases--a case
      study of Alzheimer's disease.
PG  - 517-9
LID - 10.1016/j.pneurobio.2011.11.009 [doi]
AB  - A major issue in current Alzheimer research presents in a growing dysbalance
      between a swiftly advancing biological marker and diagnostic research field
      (including advances in genetic research towards genetic profiling), key aspects
      of which have already found their way into newly proposed diagnostic criteria and
      international clinical dementia guidelines, and still rather limited and
      stagnating therapeutic and preventive options for physicians and patients
      worldwide. While Alzheimer's disease (AD) to date can be diagnosed with high
      accuracy years ahead of the late stage clinical syndromal dementia manifestation 
      supported by biomarker guided detection of AD-characteristic pathophysiological
      features, there are currently no approved preventive or disease-modifying
      therapies available and the existing approved symptomatic therapy options provide
      only modest effect sizes in already demented patients without affecting the
      overall course and progression of the chronically progressive and complex brain
      disease. This unsatisfactory situation brings along a number of important ethical
      issues that need to be addressed. We outline some of the relevant ethical
      implications mainly related to the patient's best interest as well as to the
      patient's autonomy in the specific context of medical, psychological and social
      consequences of predicting AD using multi-modal biological markers. Consent,
      disclosure, or failure to disclose, information from genetic and predictive
      biomarker results raises significant ethical concerns among IRBs, regulators and 
      advocacy groups. With the swift advances in ever earlier detection, diagnosis and
      classification in AD, a worldwide debate on ethical issues and consensus
      processes to reach a common ethical framework is warranted to safely and
      responsibly bring the best possible diagnostic measures as early as possible to
      patients and to the health care system.
CI  - Copyright (c) 2011. Published by Elsevier Ltd.
FAU - Prvulovic, David
AU  - Prvulovic D
AD  - Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University of
      Frankfurt, Heinrich-Hoffmann-Str. 10, 60528 Frankfurt, Germany.
      david.prvulovic@kgu.de
FAU - Hampel, Harald
AU  - Hampel H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111122
PL  - England
TA  - Prog Neurobiol
JT  - Progress in neurobiology
JID - 0370121
RN  - 0 (Biomarkers)
SB  - IM
MH  - Alzheimer Disease/complications/*metabolism
MH  - Biomarkers/*metabolism
MH  - Early Diagnosis
MH  - *Ethicists
MH  - Humans
MH  - Neurodegenerative Diseases/etiology/*metabolism
EDAT- 2011/12/06 06:00
MHDA- 2012/04/10 06:00
CRDT- 2011/12/06 06:00
PHST- 2011/12/06 06:00 [entrez]
PHST- 2011/12/06 06:00 [pubmed]
PHST- 2012/04/10 06:00 [medline]
AID - S0301-0082(11)00215-2 [pii]
AID - 10.1016/j.pneurobio.2011.11.009 [doi]
PST - ppublish
SO  - Prog Neurobiol. 2011 Dec;95(4):517-9. doi: 10.1016/j.pneurobio.2011.11.009. Epub 
      2011 Nov 22.


PMID- 22137002
OWN - NLM
STAT- MEDLINE
DCOM- 20120418
LR  - 20111205
IS  - 1558-349X (Electronic)
IS  - 1546-1440 (Linking)
VI  - 8
IP  - 12
DP  - 2011 Dec
TI  - Incidental findings in brain MRI research: what do we owe our subjects?
PG  - 848-52
LID - 10.1016/j.jacr.2011.08.009 [doi]
AB  - Concern regarding incidental findings on brain MRI studies has been increasing
      with the growing use of MRI as tool for scientific investigation. In this
      article, the authors provide an overview of possible approaches to address
      incidental findings. Incidental findings are surprisingly common (5%-20% of all
      examinations), although the percentage of clinically serious abnormalities is low
      (0.3%-3.4%). At present, there is no consensus concerning the optimal strategy on
      how to deal with incidental findings, in particular how to fulfill ethical
      responsibilities appropriately within the constraints of available resources.
      There are a variety of responses possible, and currently, reasonable guidelines
      exist for formulating a plan tailored to the needs of each institution that will 
      meet the reasonable expectations of subjects participating in brain research
      studies.
CI  - Copyright (c) 2011 American College of Radiology. Published by Elsevier Inc. All 
      rights reserved.
FAU - Borra, Ronald J H
AU  - Borra RJ
AD  - Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General
      Hospital and Harvard Medical School Boston, Massachusetts 02129, USA.
      ronald.borra@tyks.fi
FAU - Sorensen, A Gregory
AU  - Sorensen AG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Am Coll Radiol
JT  - Journal of the American College of Radiology : JACR
JID - 101190326
SB  - IM
MH  - Brain Diseases/*diagnosis
MH  - Humans
MH  - *Incidental Findings
MH  - Magnetic Resonance Imaging
MH  - Patient Rights/*ethics
MH  - Physician's Role
MH  - Physician-Patient Relations/*ethics
MH  - Radiology/*ethics
MH  - Truth Disclosure/*ethics
MH  - United States
EDAT- 2011/12/06 06:00
MHDA- 2012/04/19 06:00
CRDT- 2011/12/06 06:00
PHST- 2011/08/08 00:00 [received]
PHST- 2011/08/11 00:00 [accepted]
PHST- 2011/12/06 06:00 [entrez]
PHST- 2011/12/06 06:00 [pubmed]
PHST- 2012/04/19 06:00 [medline]
AID - S1546-1440(11)00448-0 [pii]
AID - 10.1016/j.jacr.2011.08.009 [doi]
PST - ppublish
SO  - J Am Coll Radiol. 2011 Dec;8(12):848-52. doi: 10.1016/j.jacr.2011.08.009.


PMID- 22137001
OWN - NLM
STAT- MEDLINE
DCOM- 20120418
LR  - 20111205
IS  - 1558-349X (Electronic)
IS  - 1546-1440 (Linking)
VI  - 8
IP  - 12
DP  - 2011 Dec
TI  - How to keep your integrity when performing sponsored (imaging) trials.
PG  - 842-7
LID - 10.1016/j.jacr.2011.08.008 [doi]
AB  - The broadening of imaging capabilities and the increasing capacity of imaging to 
      quantitate biologic processes has increased industry interest in using imaging
      methods in new drug development. Investigators participating in
      industry-sponsored trials should be aware of how such trials differ from
      investigator-initiated, grant-funded research. In particular, investigators
      should be cognizant of possible ethical conflicts in the care of patients, the
      development and analysis of data, and issues related to the dissemination of
      results.
CI  - Copyright (c) 2011 American College of Radiology. Published by Elsevier Inc. All 
      rights reserved.
FAU - Parizel, Paul M
AU  - Parizel PM
AD  - Department of Radiology, Antwerp University Hospital & University of Antwerp,
      Antwerp, Belgium. paul.parizel@ua.ac.be
FAU - van Hecke, Wim
AU  - van Hecke W
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Coll Radiol
JT  - Journal of the American College of Radiology : JACR
JID - 101190326
SB  - IM
MH  - Clinical Trials as Topic/*ethics
MH  - *Conflict of Interest
MH  - Diagnostic Imaging/*statistics & numerical data
MH  - Physicians/*ethics
MH  - Radiology/*ethics
MH  - Research Support as Topic/*ethics
MH  - United States
EDAT- 2011/12/06 06:00
MHDA- 2012/04/19 06:00
CRDT- 2011/12/06 06:00
PHST- 2011/08/08 00:00 [received]
PHST- 2011/08/11 00:00 [accepted]
PHST- 2011/12/06 06:00 [entrez]
PHST- 2011/12/06 06:00 [pubmed]
PHST- 2012/04/19 06:00 [medline]
AID - S1546-1440(11)00447-9 [pii]
AID - 10.1016/j.jacr.2011.08.008 [doi]
PST - ppublish
SO  - J Am Coll Radiol. 2011 Dec;8(12):842-7. doi: 10.1016/j.jacr.2011.08.008.


PMID- 22137000
OWN - NLM
STAT- MEDLINE
DCOM- 20120418
LR  - 20191210
IS  - 1558-349X (Electronic)
IS  - 1546-1440 (Linking)
VI  - 8
IP  - 12
DP  - 2011 Dec
TI  - Ethical considerations in CMS's coverage with evidence development.
PG  - 838-41
LID - 10.1016/j.jacr.2011.08.011 [doi]
AB  - This paper reviews the CMS coverage with evidence development policy, its manner 
      of implementation, and key ethical issues raised by the policy. The author
      describes ethical considerations and issues associated with the process of
      coverage with evidence development for generating evidence for novel or emerging 
      technologies.
CI  - Copyright (c) 2011 American College of Radiology. Published by Elsevier Inc. All 
      rights reserved.
FAU - Relyea-Chew, Annemarie
AU  - Relyea-Chew A
AD  - Department of Radiology, University of Washington, Seattle, Washington 98104,
      USA. archew@u.washington.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Coll Radiol
JT  - Journal of the American College of Radiology : JACR
JID - 101190326
SB  - IM
MH  - Centers for Medicare and Medicaid Services, U.S./*ethics
MH  - Evidence-Based Medicine/*ethics
MH  - Health Care Rationing/*ethics
MH  - Policy Making
MH  - *Public Policy
MH  - Resource Allocation/*ethics
MH  - United States
EDAT- 2011/12/06 06:00
MHDA- 2012/04/19 06:00
CRDT- 2011/12/06 06:00
PHST- 2011/08/08 00:00 [received]
PHST- 2011/08/11 00:00 [accepted]
PHST- 2011/12/06 06:00 [entrez]
PHST- 2011/12/06 06:00 [pubmed]
PHST- 2012/04/19 06:00 [medline]
AID - S1546-1440(11)00450-9 [pii]
AID - 10.1016/j.jacr.2011.08.011 [doi]
PST - ppublish
SO  - J Am Coll Radiol. 2011 Dec;8(12):838-41. doi: 10.1016/j.jacr.2011.08.011.


PMID- 22136997
OWN - NLM
STAT- MEDLINE
DCOM- 20120418
LR  - 20151119
IS  - 1558-349X (Electronic)
IS  - 1546-1440 (Linking)
VI  - 8
IP  - 12
DP  - 2011 Dec
TI  - Introduction: Ain't misbehavin': ethical considerations in the research and
      practice of radiology.
PG  - 827
LID - 10.1016/j.jacr.2011.08.012 [doi]
FAU - Carlos, Ruth C
AU  - Carlos RC
AD  - Department of Radiology, University of Michigan, Ann Arbor, Michigan 48109-0030, 
      USA. rcarlos@umich.edu
FAU - Maly-Sundgren, Pia C
AU  - Maly-Sundgren PC
LA  - eng
PT  - Introductory Journal Article
PL  - United States
TA  - J Am Coll Radiol
JT  - Journal of the American College of Radiology : JACR
JID - 101190326
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Delivery of Health Care/*ethics
MH  - Hippocratic Oath
MH  - Physicians/*ethics
MH  - Practice Patterns, Physicians'/*ethics
MH  - Radiology/*ethics
MH  - United States
EDAT- 2011/12/06 06:00
MHDA- 2012/04/19 06:00
CRDT- 2011/12/06 06:00
PHST- 2011/08/08 00:00 [received]
PHST- 2011/08/11 00:00 [accepted]
PHST- 2011/12/06 06:00 [entrez]
PHST- 2011/12/06 06:00 [pubmed]
PHST- 2012/04/19 06:00 [medline]
AID - S1546-1440(11)00451-0 [pii]
AID - 10.1016/j.jacr.2011.08.012 [doi]
PST - ppublish
SO  - J Am Coll Radiol. 2011 Dec;8(12):827. doi: 10.1016/j.jacr.2011.08.012.


PMID- 22136993
OWN - NLM
STAT- MEDLINE
DCOM- 20120418
LR  - 20151119
IS  - 1558-349X (Electronic)
IS  - 1546-1440 (Linking)
VI  - 8
IP  - 12
DP  - 2011 Dec
TI  - Ethical radiologic practice.
PG  - 818
LID - 10.1016/j.jacr.2011.08.016 [doi]
FAU - Hillman, Bruce J
AU  - Hillman BJ
LA  - eng
PT  - Editorial
PT  - Introductory Journal Article
PL  - United States
TA  - J Am Coll Radiol
JT  - Journal of the American College of Radiology : JACR
JID - 101190326
SB  - IM
MH  - Physicians/*ethics
MH  - Practice Patterns, Physicians'/*ethics
MH  - Radiology/*ethics
MH  - United States
EDAT- 2011/12/06 06:00
MHDA- 2012/04/19 06:00
CRDT- 2011/12/06 06:00
PHST- 2011/08/19 00:00 [received]
PHST- 2011/08/22 00:00 [accepted]
PHST- 2011/12/06 06:00 [entrez]
PHST- 2011/12/06 06:00 [pubmed]
PHST- 2012/04/19 06:00 [medline]
AID - S1546-1440(11)00479-0 [pii]
AID - 10.1016/j.jacr.2011.08.016 [doi]
PST - ppublish
SO  - J Am Coll Radiol. 2011 Dec;8(12):818. doi: 10.1016/j.jacr.2011.08.016.


PMID- 22136945
OWN - NLM
STAT- MEDLINE
DCOM- 20140409
LR  - 20111226
IS  - 1532-2777 (Electronic)
IS  - 0306-9877 (Linking)
VI  - 78
IP  - 2
DP  - 2012 Feb
TI  - Indexation of cerebral cell membrane phospholipid catabolism by the
      non-invasively determined cerebral 31-phosphorus neurospectroscopic
      phosphodiester peak.
PG  - 312-4
LID - 10.1016/j.mehy.2011.11.010 [doi]
AB  - Breakdown of mammalian cerebral cell membrane phospholipids releases
      phosphorylated polar head groups from the sn-3 phospholipid position, including
      phosphorylcholine and phosphorylethanolamine. Glycerophosphorylcholine and
      glycerophosphorylethanolamine are on their catabolic pathways and have been
      assigned to the phosphodiester narrow resonance obtained from 31-phosphorus
      neurospectroscopy, accounting for approximately 38% of the overall signal;
      therefore in human in vivo 31-phosphorus neurospectroscopy neuropsychiatric
      studies this narrow resonance has been used to index the catabolism of cerebral
      cell membrane phospholipids non-invasively. However, for ethical reasons direct
      assessment of this assumption has not hitherto been possible in humans. Recently,
      it has become possible to analyze signal directly from the cell membrane
      motion-restricted phospholipids by analysis of a broad resonance signal. It was
      therefore hypothesized that there should be a negative correlation between the
      phosphodiester narrow resonance and the broad resonance signal if the former does
      indeed index cell membrane phospholipid catabolism. Cerebral 31-phosphorus
      magnetic resonance spectroscopy was carried out in 54 human subjects (mean age 38
      years; 41 male), including normal volunteers and patients with schizophrenia, in 
      order potentially to widen the range of phosphodiester and broad resonance
      values. Spectra were obtained from 70 x 70 x 70 mm(3) voxels using an
      image-selected in vivo spectroscopy pulse sequence. There was a highly
      significant negative correlation between the phosphodiester resonances and the
      broad resonance signals (r=-0.509, P<0.0001). This result is consistent with the 
      hypothesis that the phosphodiester narrow resonance does index cell membrane
      phospholipid catabolism in non-invasive human neuropsychiatric studies.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Puri, B K
AU  - Puri BK
AD  - Department of Surgery and Cancer, Imperial College London, London, UK.
      basant.puri@imperial.ac.uk
LA  - eng
GR  - Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111202
PL  - United States
TA  - Med Hypotheses
JT  - Medical hypotheses
JID - 7505668
RN  - 0 (Esters)
RN  - 0 (Phosphatidylethanolamines)
RN  - 0 (Phospholipids)
RN  - 0 (Phosphorus Isotopes)
RN  - 1190-00-7 (glycerophosphoethanolamine)
RN  - 60M22SGW66 (Glycerylphosphorylcholine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain/*metabolism
MH  - Cell Membrane/*metabolism
MH  - Esters/metabolism
MH  - Female
MH  - Glycerylphosphorylcholine/metabolism
MH  - Humans
MH  - Magnetic Resonance Spectroscopy
MH  - Male
MH  - Metabolism
MH  - Middle Aged
MH  - Models, Theoretical
MH  - Phosphatidylethanolamines/metabolism
MH  - Phospholipids/*metabolism
MH  - Phosphorus Isotopes/*metabolism
MH  - Phosphorylation
MH  - Schizophrenia/metabolism
MH  - Young Adult
EDAT- 2011/12/06 06:00
MHDA- 2014/04/10 06:00
CRDT- 2011/12/06 06:00
PHST- 2011/10/04 00:00 [received]
PHST- 2011/11/10 00:00 [accepted]
PHST- 2011/12/06 06:00 [entrez]
PHST- 2011/12/06 06:00 [pubmed]
PHST- 2014/04/10 06:00 [medline]
AID - S0306-9877(11)00582-2 [pii]
AID - 10.1016/j.mehy.2011.11.010 [doi]
PST - ppublish
SO  - Med Hypotheses. 2012 Feb;78(2):312-4. doi: 10.1016/j.mehy.2011.11.010. Epub 2011 
      Dec 2.


PMID- 22136366
OWN - NLM
STAT- MEDLINE
DCOM- 20120410
LR  - 20141120
IS  - 1477-3848 (Electronic)
IS  - 0743-4618 (Linking)
VI  - 27
IP  - 4
DP  - 2011 Dec
TI  - The storybook method: research feedback with young participants.
PG  - 279-91
LID - 10.3109/07434618.2011.630019 [doi]
AB  - Children are valuable informants for social research; however, their
      participation presents additional ethical and practical challenges. Of these
      challenges, feedback to verify the researchers' interpretations drawn from
      children's data, and the dissemination of project findings to young participants,
      have proven difficult to overcome. In this paper, we outline the Storybook
      method, an approach to feedback in research with young children. In the example
      study, illustrations, interactive pop-ups, and third-person disclosure were used 
      to aid children aged 7-9 years to overcome the power imbalance in interviews with
      adults. The Storybook method facilitated active participation in the validation
      process. Potential modifications of the method for use with older populations,
      including adults with intellectual disabilities, complex communication needs, and
      those requiring alternate access to written texts, are also explored.
FAU - Anderson, Kate
AU  - Anderson K
AD  - The University of Sydney, Australia. kate.anderson@sydney.edu.au
FAU - Balandin, Susan
AU  - Balandin S
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Augment Altern Commun
JT  - Augmentative and alternative communication (Baltimore, Md. : 1985)
JID - 8504574
SB  - IM
MH  - Adolescent
MH  - Books
MH  - Child
MH  - Communication Barriers
MH  - Communication Disorders/*psychology/*rehabilitation
MH  - Disabled Children/*psychology/*rehabilitation
MH  - Feedback, Psychological
MH  - Female
MH  - Humans
MH  - Intellectual Disability/ethnology/psychology
MH  - Interviews as Topic/methods
MH  - Male
MH  - *Narration
MH  - Psychology, Child
MH  - *Qualitative Research
EDAT- 2011/12/06 06:00
MHDA- 2012/04/11 06:00
CRDT- 2011/12/06 06:00
PHST- 2011/12/06 06:00 [entrez]
PHST- 2011/12/06 06:00 [pubmed]
PHST- 2012/04/11 06:00 [medline]
AID - 10.3109/07434618.2011.630019 [doi]
PST - ppublish
SO  - Augment Altern Commun. 2011 Dec;27(4):279-91. doi: 10.3109/07434618.2011.630019.


PMID- 22136331
OWN - NLM
STAT- MEDLINE
DCOM- 20120325
LR  - 20181201
IS  - 1445-6354 (Electronic)
IS  - 1445-6354 (Linking)
VI  - 11
IP  - 4
DP  - 2011
TI  - 'Any body is better than nobody?' Ethical questions around recruiting and/or
      retaining health professionals in rural areas.
PG  - 1867
AB  - INTRODUCTION: The literature on recruiting and/or retaining health professionals 
      in rural areas focuses primarily on the development of recruitment and retention 
      strategies and assessing whether such strategies are effective. The objective of 
      this article is to argue that it is important for all stakeholders involved in
      rural recruitment and/or retention processes to consider their decisions and
      actions from an ethics perspective. Recruitment and/or retention processes are
      not value neutral and it is important to understand their ethical dimensions.
      METHODS: From the literature, elements of the recruitment and/or retention
      strategies that have been employed were identified and organised in respect of
      levels of governance (namely, the levels of health system/government, community, 
      and individual health professionals). The elements identified in these levels
      were subjected to analysis to identify their ethical dimensions and to determine 
      whether a clash or complement of values arose at each level of governance or
      between governance levels. RESULTS: There is very little literature in this area 
      that considers the ethical dimensions of rural recruitment and/or retention
      processes. However, all policies and practices have ethical dimensions that need 
      to be identified and understood as they may have significant implications for
      recruitment and/or retention processes. CONCLUSIONS: This article recommends the 
      application of an ethics perspective when reflecting on rural recruitment and/or 
      retention strategies. The collective decisions of all involved in rural
      recruitment and/or retention processes may fundamentally influence the 'health'
      (broadly understood) of rural communities.
FAU - Simpson, C
AU  - Simpson C
AD  - Department of Bioethics, Dalhousie University, Halifax, Nova Scotia, Canada.
FAU - McDonald, F
AU  - McDonald F
LA  - eng
PT  - Journal Article
DEP - 20111125
PL  - Australia
TA  - Rural Remote Health
JT  - Rural and remote health
JID - 101174860
SB  - IM
MH  - Career Choice
MH  - Developing Countries
MH  - Health Personnel/ethics
MH  - Humans
MH  - Personnel Loyalty
MH  - Personnel Selection/*ethics
MH  - Rural Health Services/*ethics
MH  - Workforce
EDAT- 2011/12/06 06:00
MHDA- 2012/03/27 06:00
CRDT- 2011/12/06 06:00
PHST- 2011/12/06 06:00 [entrez]
PHST- 2011/12/06 06:00 [pubmed]
PHST- 2012/03/27 06:00 [medline]
AID - 1867 [pii]
PST - ppublish
SO  - Rural Remote Health. 2011;11(4):1867. Epub 2011 Nov 25.


PMID- 22135924
OWN - NLM
STAT- MEDLINE
DCOM- 20120103
LR  - 20190608
IS  - 1019-9128 (Print)
IS  - 1019-9128 (Linking)
VI  - 82
IP  - 2
DP  - 2011 Jun
TI  - A survey of the prevalence of blowfly strike and the control measures used in the
      Ruens area of the Western Cape Province of South Africa.
PG  - 107-15
AB  - Blowfly strike and the methods used to combat blowfly strike were recorded on 33 
      properties in the Ruens area of South Africa during 2003/2004. Data were recorded
      on Merino and Dohne Merino hoggets (n = 4951) with at least 3 months' wool
      growth. The following data were captured: presence or absence of strike, site of 
      the strike (body or breech), presence or absence of dermatophilosis as well as
      subjective scores for wool quality and wool colour. Control measures recorded
      include: chemical treatment (preventative and spot treatment), crutching,
      mulesing and the use of the Lucitrap system. Blowfly strike was not significantly
      influenced by gender or breed. Hoggets suffering from dermatophilosis were more
      likely to be struck, compared with contemporaries not suffering from the skin
      disorder (0.057 vs 0.027; P < 0.05). Merino hoggets generally had higher scores
      than their Dohne Merino contemporaries for wool quality (32.6 vs 27.4; P < 0.05) 
      and wool colour (29.0 vs 27.2; P < 0.05). There was an indication that the
      Lucitrap system may have reduced flystrike, but the effect was not statistically 
      significant (P = 0.19 for overall strikes and P = 0.12 for body strike). The
      Mules operation benefited overall flystrike (0.013 vs 0.110; P < 0.05); mainly
      through an effect on breech strike (0.010 vs 0.109; P < 0.05). The proportion of 
      fly strikes increased with wool length, and declined with an increase in farm
      size in wool colour score. None of the ethically acceptable control measures
      assessed could substantially reduce blowfly strike on their own, and an
      integrated pest management programme was proposed.
FAU - Scholtz, A J
AU  - Scholtz AJ
AD  - Institute for Animal Production: Elsenburg, Private Bag X1, Elsenburg 7607, South
      Africa. ansies@elsenburg.com
FAU - Cloete, S W P
AU  - Cloete SW
FAU - du Toit, E
AU  - du Toit E
FAU - van Wyk, J B
AU  - van Wyk JB
FAU - van der Linde, T C de K
AU  - van der Linde TC
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - J S Afr Vet Assoc
JT  - Journal of the South African Veterinary Association
JID - 7503122
SB  - IM
MH  - Animals
MH  - Diptera
MH  - Ectoparasitic Infestations/epidemiology/prevention & control/*veterinary
MH  - Female
MH  - Insect Control/*methods
MH  - Male
MH  - Myiasis/epidemiology/prevention & control/*veterinary
MH  - Sheep
MH  - Sheep Diseases/*epidemiology/prevention & control
MH  - South Africa/epidemiology
MH  - Wool/*standards
EDAT- 2011/12/06 06:00
MHDA- 2012/01/04 06:00
CRDT- 2011/12/06 06:00
PHST- 2011/12/06 06:00 [entrez]
PHST- 2011/12/06 06:00 [pubmed]
PHST- 2012/01/04 06:00 [medline]
AID - 10.4102/jsava.v82i2.43 [doi]
PST - ppublish
SO  - J S Afr Vet Assoc. 2011 Jun;82(2):107-15. doi: 10.4102/jsava.v82i2.43.


PMID- 22134580
OWN - NLM
STAT- MEDLINE
DCOM- 20120808
LR  - 20220318
IS  - 1573-3599 (Electronic)
IS  - 1059-7700 (Linking)
VI  - 21
IP  - 2
DP  - 2012 Apr
TI  - Essential elements of genetic cancer risk assessment, counseling, and testing:
      updated recommendations of the National Society of Genetic Counselors.
PG  - 151-61
LID - 10.1007/s10897-011-9462-x [doi]
AB  - Updated from their original publication in 2004, these cancer genetic counseling 
      recommendations describe the medical, psychosocial, and ethical ramifications of 
      counseling at-risk individuals through genetic cancer risk assessment with or
      without genetic testing. They were developed by members of the Practice Issues
      Subcommittee of the National Society of Genetic Counselors Familial Cancer Risk
      Counseling Special Interest Group. The information contained in this document is 
      derived from extensive review of the current literature on cancer genetic risk
      assessment and counseling as well as the personal expertise of genetic counselors
      specializing in cancer genetics. The recommendations are intended to provide
      information about the process of genetic counseling and risk assessment for
      hereditary cancer disorders rather than specific information about individual
      syndromes. Essential components include the intake, cancer risk assessment,
      genetic testing for an inherited cancer syndrome, informed consent, disclosure of
      genetic test results, and psychosocial assessment. These recommendations should
      not be construed as dictating an exclusive course of management, nor does use of 
      such recommendations guarantee a particular outcome. These recommendations do not
      displace a health care provider's professional judgment based on the clinical
      circumstances of a client.
FAU - Riley, Bronson D
AU  - Riley BD
AD  - Southeast Nebraska Cancer Center, Lincoln, NE, USA.
      bronsonr@leadingcancercare.com
FAU - Culver, Julie O
AU  - Culver JO
FAU - Skrzynia, Cecile
AU  - Skrzynia C
FAU - Senter, Leigha A
AU  - Senter LA
FAU - Peters, June A
AU  - Peters JA
FAU - Costalas, Josephine W
AU  - Costalas JW
FAU - Callif-Daley, Faith
AU  - Callif-Daley F
FAU - Grumet, Sherry C
AU  - Grumet SC
FAU - Hunt, Katherine S
AU  - Hunt KS
FAU - Nagy, Rebecca S
AU  - Nagy RS
FAU - McKinnon, Wendy C
AU  - McKinnon WC
FAU - Petrucelli, Nancie M
AU  - Petrucelli NM
FAU - Bennett, Robin L
AU  - Bennett RL
FAU - Trepanier, Angela M
AU  - Trepanier AM
LA  - eng
PT  - Journal Article
DEP - 20111202
PL  - United States
TA  - J Genet Couns
JT  - Journal of genetic counseling
JID - 9206865
SB  - IM
MH  - *Genetic Counseling
MH  - Genetic Predisposition to Disease
MH  - *Genetic Testing
MH  - Humans
MH  - Neoplasms/*genetics
MH  - *Risk Assessment
MH  - Workforce
EDAT- 2011/12/03 06:00
MHDA- 2012/08/09 06:00
CRDT- 2011/12/03 06:00
PHST- 2011/11/09 00:00 [received]
PHST- 2011/11/16 00:00 [accepted]
PHST- 2011/12/03 06:00 [entrez]
PHST- 2011/12/03 06:00 [pubmed]
PHST- 2012/08/09 06:00 [medline]
AID - 10.1007/s10897-011-9462-x [doi]
PST - ppublish
SO  - J Genet Couns. 2012 Apr;21(2):151-61. doi: 10.1007/s10897-011-9462-x. Epub 2011
      Dec 2.


PMID- 22133938
OWN - NLM
STAT- MEDLINE
DCOM- 20120123
LR  - 20111202
IS  - 1097-6752 (Electronic)
IS  - 0889-5406 (Linking)
VI  - 140
IP  - 6
DP  - 2011 Dec
TI  - Ethics in orthodontics. When patients are used as currency.
PG  - 759
LID - 10.1016/j.ajodo.2011.08.015 [doi]
FAU - Greco, Peter M
AU  - Greco PM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Orthod Dentofacial Orthop
JT  - American journal of orthodontics and dentofacial orthopedics : official
      publication of the American Association of Orthodontists, its constituent
      societies, and the American Board of Orthodontics
JID - 8610224
SB  - IM
MH  - *Ethics, Dental
MH  - Humans
MH  - Orthodontics/*ethics
MH  - Referral and Consultation/*ethics
MH  - Remuneration
EDAT- 2011/12/03 06:00
MHDA- 2012/01/24 06:00
CRDT- 2011/12/03 06:00
PHST- 2011/08/01 00:00 [received]
PHST- 2011/08/01 00:00 [revised]
PHST- 2011/08/01 00:00 [accepted]
PHST- 2011/12/03 06:00 [entrez]
PHST- 2011/12/03 06:00 [pubmed]
PHST- 2012/01/24 06:00 [medline]
AID - S0889-5406(11)00789-X [pii]
AID - 10.1016/j.ajodo.2011.08.015 [doi]
PST - ppublish
SO  - Am J Orthod Dentofacial Orthop. 2011 Dec;140(6):759. doi:
      10.1016/j.ajodo.2011.08.015.


PMID- 22133169
OWN - NLM
STAT- MEDLINE
DCOM- 20120830
LR  - 20181201
IS  - 1092-0684 (Electronic)
IS  - 1092-0684 (Linking)
VI  - 31
IP  - 6
DP  - 2011 Dec
TI  - The management of incidental low-grade gliomas using magnetic resonance imaging: 
      systematic review and optimal treatment paradigm.
PG  - E12
LID - 10.3171/2011.9.FOCUS11219 [doi]
AB  - OBJECT: The discovery of incidental low-grade gliomas (LGGs) on MR imaging is
      rare, and currently there is no existing protocol for management of these
      lesions. Various studies have approached the dilemma of managing patients with
      incidental LGGs. While some advocate surgery and radiotherapy, others reserve
      surgery until there is radiological evidence of growth. For neurosurgeons and
      radiologists, determining the course of action after routine brain imaging poses 
      not only a medical but also an ethical dilemma. The authors conducted a
      systematic review of case reports and case series in hopes of enhancing the
      current understanding of the management options for these rare lesions. METHODS: 
      A PubMed search was performed to include all relevant MR imaging studies in which
      management of suspected incidental LGG was reported. Comparisons were made
      between the surgical treatment arm and the active surveillance arm in terms of
      outcome, mode of discovery, reasons for treatment, and histology. RESULTS: Nine
      studies with 72 patients were included in this study (56 in the surgical arm and 
      16 in the active surveillance arm). Within the surgical arm, 49% remained deficit
      free after treatment, 25% showed evidence of tumor progression, 13% underwent a
      second treatment, and 7% died. The active surveillance group resulted in no
      unanticipated adverse events, with serial imaging revealing no tumor growth in
      all cases. Lesion regression was reported in 31% of this group. The surgical
      arm's mortality rate was 7% compared with 0% in the active surveillance arm.
      CONCLUSIONS: Treatment decisions for incidental LGG should be individualized
      based on presenting symptoms and radiological evidence of growth. The
      asymptomatic patient may be monitored safely with serial MR imaging and
      occasionally PET scanning before treatment is initiated. In patients presenting
      with nonspecific symptoms or concurrent symptomatic lesions, treatment may be
      initiated earlier to reduce potential morbidity. All treatment decisions must be 
      tempered by patient factors and expectations of anticipated benefit.
FAU - Shah, Ashish H
AU  - Shah AH
AD  - Department of Neurological Surgery, University of Miami, Miami, Florida 33136,
      USA.
FAU - Madhavan, Karthik
AU  - Madhavan K
FAU - Heros, Deborah
AU  - Heros D
FAU - Raper, Daniel M S
AU  - Raper DM
FAU - Iorgulescu, J Bryan
AU  - Iorgulescu JB
FAU - Lally, Brian E
AU  - Lally BE
FAU - Komotar, Ricardo J
AU  - Komotar RJ
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
PL  - United States
TA  - Neurosurg Focus
JT  - Neurosurgical focus
JID - 100896471
SB  - IM
MH  - Brain Neoplasms/*diagnosis/*therapy
MH  - Disease Management
MH  - Glioma/*diagnosis/*therapy
MH  - Humans
MH  - *Incidental Findings
MH  - *Magnetic Resonance Imaging
MH  - Prospective Studies
MH  - Retrospective Studies
MH  - Treatment Outcome
EDAT- 2011/12/03 06:00
MHDA- 2012/08/31 06:00
CRDT- 2011/12/03 06:00
PHST- 2011/12/03 06:00 [entrez]
PHST- 2011/12/03 06:00 [pubmed]
PHST- 2012/08/31 06:00 [medline]
AID - 10.3171/2011.9.FOCUS11219 [doi]
PST - ppublish
SO  - Neurosurg Focus. 2011 Dec;31(6):E12. doi: 10.3171/2011.9.FOCUS11219.


PMID- 22132720
OWN - NLM
STAT- MEDLINE
DCOM- 20120313
LR  - 20120113
IS  - 0148-4834 (Print)
IS  - 0148-4834 (Linking)
VI  - 51
IP  - 1
DP  - 2012 Jan
TI  - Conducting multisite research studies in nursing education: brief practice of CPR
      skills as an exemplar.
PG  - 23-8
LID - 10.3928/01484834-20111130-05 [doi]
AB  - Few large, multisite studies have been conducted in nursing education, and
      literature pertaining to conducting those studies is lacking. We recently
      completed a randomized trial to examine the effects of brief practice on nursing 
      students' retention of CPR psychomotor skills. The purpose of this article is to 
      describe strategies for implementing a multisite study in nursing education,
      using our research as an exemplar. Strategies are presented for structuring a
      multisite study; selecting, preparing, and communicating with team members across
      sites; selecting sites; recruiting and retaining participants; managing the
      technical aspects of an intervention; and collecting and managing data. Ethical
      considerations also are explored.
CI  - Copyright 2012, SLACK Incorporated.
FAU - Oermann, Marilyn H
AU  - Oermann MH
AD  - Adult/Geriatric Health, School of Nursing, University of North Carolina at Chapel
      Hill, 433 Carrington Hall, CB # 7460, Chapel Hill, NC 27599-7460, USA.
      moermann@email.unc.edu
FAU - Hallmark, Beth F
AU  - Hallmark BF
FAU - Haus, Carol
AU  - Haus C
FAU - Kardong-Edgren, Suzie E
AU  - Kardong-Edgren SE
FAU - McColgan, Jacqueline Keegan
AU  - McColgan JK
FAU - Rogers, Nancy
AU  - Rogers N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111130
PL  - United States
TA  - J Nurs Educ
JT  - The Journal of nursing education
JID - 7705432
SB  - IM
MH  - Cardiopulmonary Resuscitation/*education
MH  - Data Collection/methods
MH  - Humans
MH  - Information Dissemination
MH  - *Multicenter Studies as Topic
MH  - Nursing Education Research/*organization & administration
MH  - Patient Selection
MH  - *Randomized Controlled Trials as Topic
MH  - Research Design
MH  - Research Personnel/education/organization & administration
MH  - United States
EDAT- 2011/12/03 06:00
MHDA- 2012/03/14 06:00
CRDT- 2011/12/03 06:00
PHST- 2011/07/25 00:00 [received]
PHST- 2011/10/12 00:00 [accepted]
PHST- 2011/12/03 06:00 [entrez]
PHST- 2011/12/03 06:00 [pubmed]
PHST- 2012/03/14 06:00 [medline]
AID - 10.3928/01484834-20111130-05 [doi]
PST - ppublish
SO  - J Nurs Educ. 2012 Jan;51(1):23-8. doi: 10.3928/01484834-20111130-05. Epub 2011
      Nov 30.


PMID- 22132669
OWN - NLM
STAT- MEDLINE
DCOM- 20120103
LR  - 20111202
IS  - 0041-3674 (Print)
IS  - 0041-3674 (Linking)
VI  - 64
IP  - 9
DP  - 2011 Oct
TI  - Integrity in action. Boards' compliance oversight sets the standard for ethical, 
      legal practices.
PG  - 17-9, 1
AB  - The board's compliance oversight responsibility starts with engaged, educated
      trustees. Learn the basics here.
FAU - Ness, H Rebecca
AU  - Ness HR
AD  - becness@myfairpoint.net
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Trustee
JT  - Trustee : the journal for hospital governing boards
JID - 21330020R
MH  - Governing Board/*ethics/*legislation & jurisprudence
MH  - *Guideline Adherence
MH  - Humans
MH  - United States
EDAT- 2011/12/03 06:00
MHDA- 2012/01/04 06:00
CRDT- 2011/12/03 06:00
PHST- 2011/12/03 06:00 [entrez]
PHST- 2011/12/03 06:00 [pubmed]
PHST- 2012/01/04 06:00 [medline]
PST - ppublish
SO  - Trustee. 2011 Oct;64(9):17-9, 1.


PMID- 22132618
OWN - NLM
STAT- MEDLINE
DCOM- 20120105
LR  - 20111202
IS  - 0008-7335 (Print)
IS  - 0008-7335 (Linking)
VI  - 150
IP  - 9
DP  - 2011
TI  - [Human dignity and medical ethics].
PG  - 499-501
AB  - The concept of human dignity and the respect to it have issued from various
      sources--philosophical, religious and cultural. The text deals with the thinking 
      of some philosophers (intrinsic dignity versus attributed dignity), with
      religious thoughts (explaining the dignity of man as being created in God's
      image) and discusses the important declarations, especially the Universal
      Declaration of Human Rights. This declaration (UN, 1948) recognizes, in consent
      with both--the best philosophical tradition and biblical faith, the inherent
      dignity and worth of every human being (person); it is the first principle and
      the inescapable grounding for all human rights. The term human dignity is hotly
      debated in the present bioethics arena; nevertheless it is the source of
      considerable and dangerous confusion as well. Some bioethicists deny implicitly
      or even explicitly the dignity of every human being (they conflate intrinsic and 
      attributed dignity), and others proclaim that dignity is a useless concept. But
      the respect to human dignity is the cornerstone of all medical ethics--this
      discipline will be changed into ethical parody without it. It is therefore
      necessary to see the problems in the broader context and to stand firmly on the
      right side of the dispute: on the side of each and every patient.
FAU - Munzarova, Marta
AU  - Munzarova M
AD  - LF MU, Brno Heinrichova 25, 602 00 Brno. mmunzar@med.muni.cz
LA  - cze
PT  - English Abstract
PT  - Journal Article
TT  - Dustojnost cloveka a lekarska etika.
PL  - Czech Republic
TA  - Cas Lek Cesk
JT  - Casopis lekaru ceskych
JID - 0004743
SB  - IM
MH  - *Ethics, Medical
MH  - *Human Rights
MH  - Humans
MH  - *Personhood
EDAT- 2011/12/03 06:00
MHDA- 2012/01/06 06:00
CRDT- 2011/12/03 06:00
PHST- 2011/12/03 06:00 [entrez]
PHST- 2011/12/03 06:00 [pubmed]
PHST- 2012/01/06 06:00 [medline]
PST - ppublish
SO  - Cas Lek Cesk. 2011;150(9):499-501.


PMID- 22132383
OWN - NLM
STAT- MEDLINE
DCOM- 20120328
LR  - 20151119
IS  - 1172-6156 (Electronic)
IS  - 1172-6156 (Linking)
VI  - 3
IP  - 4
DP  - 2011 Dec 1
TI  - Clinical teachers working in primary care: what would they like changed in the
      medical school?
PG  - 298-306
AB  - INTRODUCTION: General practitioners (GPs) working as clinical teachers are likely
      to influence medical students' level of community-based learning. This paper
      aimed to ascertain clinical teachers' views in relation to The University of
      Auckland about their clinical learning environment. METHOD: A total of 34
      clinical teachers working in primary care contributed to this study. To gauge
      their level of involvement in teaching and learning, the clinical teachers were
      asked about issues such as their confidence, available time, sufficient clinical 
      learning opportunities, clear learning objectives to teach students and what they
      would like changed. FINDINGS: The GPs appeared confident, felt there were
      sufficient learning opportunities for students and that their students were part 
      of the team. Less experienced teachers expressed less confidence than more
      experienced peers. There was some hesitancy in terms of coping with time and
      feedback. Some clinical teachers were unclear about the learning objectives
      presented to students. CONCLUSION: Several issues that emerged--including
      available time and financial rewards--are difficult to resolve. Curriculum and
      selection are evolving issues requiring constant monitoring and alignment with
      increasing numbers of students studying medicine, increased ethical awareness,
      more diverse teaching systems and more advanced technologies. Non-faculty
      clinicians need adequate representation on curriculum committees and involvement 
      in clinical education initiatives. Issues of cultural competency and professional
      development were raised, suggesting the need for more established links between
      university and GPs.
FAU - Hawken, Susan J
AU  - Hawken SJ
AD  - Department of Psychological Medicine, Faculty of Medical and Health Sciences, The
      University of Auckland, Auckland, New Zealand. s.hawken@auckland.ac.nz
FAU - Henning, Marcus A
AU  - Henning MA
FAU - Pinnock, Ralph
AU  - Pinnock R
FAU - Shulruf, Boaz
AU  - Shulruf B
FAU - Bagg, Warwick
AU  - Bagg W
LA  - eng
PT  - Journal Article
DEP - 20111201
PL  - Australia
TA  - J Prim Health Care
JT  - Journal of primary health care
JID - 101524060
SB  - IM
MH  - *Attitude of Health Personnel
MH  - General Practitioners/*psychology
MH  - Humans
MH  - New Zealand
MH  - Primary Health Care/*organization & administration
MH  - Qualitative Research
MH  - Schools, Medical/*organization & administration
MH  - Surveys and Questionnaires
MH  - *Teaching
EDAT- 2011/12/02 06:00
MHDA- 2012/03/29 06:00
CRDT- 2011/12/02 06:00
PHST- 2011/12/02 06:00 [entrez]
PHST- 2011/12/02 06:00 [pubmed]
PHST- 2012/03/29 06:00 [medline]
PST - epublish
SO  - J Prim Health Care. 2011 Dec 1;3(4):298-306.


PMID- 22131590
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 0034-673X (Print)
IS  - 0034-673X (Linking)
VI  - 53
IP  - 2
DP  - 2011 Nov
TI  - Denominational Research Report: Attitudes of Taiwan Catholics Toward Sexual
      Ethics.
PG  - 247-248
FAU - Chen, Chieh-Ju
AU  - Chen CJ
LA  - eng
PT  - Journal Article
DEP - 20110921
PL  - United States
TA  - Rev Relig Res
JT  - Review of religious research
JID - 20130330R
PMC - PMC3208115
EDAT- 2011/12/02 06:00
MHDA- 2011/12/02 06:01
CRDT- 2011/12/02 06:00
PHST- 2011/12/02 06:00 [entrez]
PHST- 2011/12/02 06:00 [pubmed]
PHST- 2011/12/02 06:01 [medline]
AID - 10.1007/s13644-011-0022-5 [doi]
AID - 22 [pii]
PST - ppublish
SO  - Rev Relig Res. 2011 Nov;53(2):247-248. doi: 10.1007/s13644-011-0022-5. Epub 2011 
      Sep 21.


PMID- 22131575
OWN - NLM
STAT- MEDLINE
DCOM- 20120124
LR  - 20211021
IS  - 0008-5286 (Print)
IS  - 0008-5286 (Linking)
VI  - 52
IP  - 6
DP  - 2011 Jun
TI  - An ethicist's commentary on the credibility of animal care and use committees.
PG  - 584-6
FAU - Rollin, Bernard E
AU  - Rollin BE
LA  - eng
PT  - Editorial
PL  - Canada
TA  - Can Vet J
JT  - The Canadian veterinary journal = La revue veterinaire canadienne
JID - 0004653
SB  - IM
MH  - *Animal Care Committees
MH  - Animal Experimentation/*ethics
MH  - *Animal Welfare
MH  - Animals
MH  - Animals, Laboratory
MH  - Humans
MH  - Veterinary Medicine/*ethics
PMC - PMC3095155
EDAT- 2011/12/02 06:00
MHDA- 2012/01/25 06:00
CRDT- 2011/12/02 06:00
PHST- 2011/12/02 06:00 [entrez]
PHST- 2011/12/02 06:00 [pubmed]
PHST- 2012/01/25 06:00 [medline]
PST - ppublish
SO  - Can Vet J. 2011 Jun;52(6):584-6.


PMID- 22131543
OWN - NLM
STAT- MEDLINE
DCOM- 20120209
LR  - 20211021
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Linking)
VI  - 77
IP  - 24
DP  - 2011 Dec 13
TI  - A practical approach to incidental findings in neuroimaging research.
PG  - 2123-7
LID - 10.1212/WNL.0b013e31823d7687 [doi]
AB  - OBJECTIVE: We describe the systematic approach to incidental findings (IFs) used 
      at the Mind Research Network (MRN) where all MRI scans receive neuroradiologist
      interpretation and participants are provided results. METHODS: From 2004 to 2011,
      8,545 MRI scans were acquired by 45 researchers. As mandated by MRN's external
      institutional review board, all structural sequences were evaluated by a clinical
      neuroradiologist who generated a report that included recommendations for
      referral if indicated. Investigators received a copy of their participants'
      reports, which were also mailed to participants unless they specifically
      declined. To better understand the impact of the radiology review process, a
      financial analysis was completed in addition to a follow-up phone survey to
      characterize participant perceptions regarding receiving their MRI scan results. 
      RESULTS: The radiologist identified IFs in 34% of the 4,447 participants. Of
      those with IFs (n = 1,518), the radiologist recommended urgent or immediate
      referral for 2.5% and routine referral for 17%. For 80.5%, no referral was
      recommended. Estimated annual cost for this approach including support for the
      neuroradiologist, medical director, and ancillary staff is approximately $60,000 
      or $24/scan. The results of the retrospective phone survey showed that 92% of
      participants appreciated receiving their MRI report, and the majority stated it
      increased their likelihood of volunteering for future studies. CONCLUSIONS:
      Addressing IFs in a cost-effective and consistent manner is possible by adopting 
      a policy that provides neuroradiology interpretation and offers participant
      assistance with clinical follow-up when necessary. Our experience suggests that
      an ethical, institution-wide approach to IFs can be implemented with minimal
      investigator burden.
FAU - Shoemaker, J M
AU  - Shoemaker JM
AD  - Mind Research Network, Albuquerque, NM, USA. jroberts@mrn.org
FAU - Holdsworth, M T
AU  - Holdsworth MT
FAU - Aine, C
AU  - Aine C
FAU - Calhoun, V D
AU  - Calhoun VD
FAU - de La Garza, R
AU  - de La Garza R
FAU - Feldstein Ewing, S W
AU  - Feldstein Ewing SW
FAU - Hayek, R
AU  - Hayek R
FAU - Mayer, A R
AU  - Mayer AR
FAU - Kiehl, K A
AU  - Kiehl KA
FAU - Petree, L E
AU  - Petree LE
FAU - Sanjuan, P
AU  - Sanjuan P
FAU - Scott, A
AU  - Scott A
FAU - Stephen, J
AU  - Stephen J
FAU - Phillips, J P
AU  - Phillips JP
LA  - eng
GR  - 1-R01-HD059856-01A2/HD/NICHD NIH HHS/United States
GR  - R24-HD050836/HD/NICHD NIH HHS/United States
GR  - 5-R01-AA014886/AA/NIAAA NIH HHS/United States
GR  - 1-R41-NS062474-01/NS/NINDS NIH HHS/United States
GR  - 1-R01-DA026505-01A1/DA/NIDA NIH HHS/United States
GR  - 5-U24-AA014811-06/AA/NIAAA NIH HHS/United States
GR  - 1-R01-DA025074/DA/NIDA NIH HHS/United States
GR  - 1-R01-DA14178-01/DA/NIDA NIH HHS/United States
GR  - R01-MH071896/MH/NIMH NIH HHS/United States
GR  - 1-R21-DA029464/DA/NIDA NIH HHS/United States
GR  - 5-P20-RR021938/RR/NCRR NIH HHS/United States
GR  - 1-R21-DA025135/DA/NIDA NIH HHS/United States
GR  - 5-M01-RR000997-35/RR/NCRR NIH HHS/United States
GR  - P20-AA017068/AA/NIAAA NIH HHS/United States
GR  - R01-MH072681/MH/NIMH NIH HHS/United States
GR  - 1-R01-EB002618-01/EB/NIBIB NIH HHS/United States
GR  - 5-R21-HD041237-02/HD/NICHD NIH HHS/United States
GR  - 1-R21-DA027149-A1/DA/NIDA NIH HHS/United States
GR  - 1-R01-AG029495-03/AG/NIA NIH HHS/United States
GR  - 1-R03-DA022435-01A1/DA/NIDA NIH HHS/United States
GR  - 1-KL2-RR31976-1,/RR/NCRR NIH HHS/United States
GR  - R01 MH085010/MH/NIMH NIH HHS/United States
GR  - 1-R21-DA027149-01/DA/NIDA NIH HHS/United States
GR  - 5-P20-AA017068/AA/NIAAA NIH HHS/United States
GR  - R01 DA026505/DA/NIDA NIH HHS/United States
GR  - 1-R03-DA027892-01/DA/NIDA NIH HHS/United States
GR  - R21-NS064464-01A1/NS/NINDS NIH HHS/United States
GR  - 3-R01-NS052305/NS/NINDS NIH HHS/United States
GR  - 1-R21-MH080141-02/MH/NIMH NIH HHS/United States
GR  - 5-M01-RR00997/RR/NCRR NIH HHS/United States
GR  - 1-UL1-RR031977/RR/NCRR NIH HHS/United States
GR  - R01-HL04722-A5/HL/NHLBI NIH HHS/United States
GR  - 1-R01-MH085010-01A1/MH/NIMH NIH HHS/United States
GR  - DA025074/DA/NIDA NIH HHS/United States
GR  - R01-AA017390/AA/NIAAA NIH HHS/United States
GR  - R01-DA020870/DA/NIDA NIH HHS/United States
GR  - 1-R01-AG020302-05/AG/NIA NIH HHS/United States
GR  - 5-R01-AA012238/AA/NIAAA NIH HHS/United States
GR  - R01-MH070539/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20111130
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
SB  - IM
MH  - Brain/*pathology
MH  - Ethics Committees, Research
MH  - Humans
MH  - *Incidental Findings
MH  - Magnetic Resonance Imaging
MH  - Neuroimaging/*methods
MH  - Research Design
MH  - Retrospective Studies
PMC - PMC3235350
EDAT- 2011/12/02 06:00
MHDA- 2012/02/10 06:00
CRDT- 2011/12/02 06:00
PHST- 2011/12/02 06:00 [entrez]
PHST- 2011/12/02 06:00 [pubmed]
PHST- 2012/02/10 06:00 [medline]
AID - WNL.0b013e31823d7687 [pii]
AID - 10.1212/WNL.0b013e31823d7687 [doi]
PST - ppublish
SO  - Neurology. 2011 Dec 13;77(24):2123-7. doi: 10.1212/WNL.0b013e31823d7687. Epub
      2011 Nov 30.


PMID- 22131038
OWN - NLM
STAT- MEDLINE
DCOM- 20120925
LR  - 20211021
IS  - 1590-3478 (Electronic)
IS  - 1590-1874 (Linking)
VI  - 33
IP  - 3
DP  - 2012 Jun
TI  - Persistent vegetative state: an ethical reappraisal.
PG  - 695-700
LID - 10.1007/s10072-011-0867-y [doi]
AB  - New knowledge from scientific research on vegetative state (VS) and its
      consequences in clinical practice are reviewed. The ambiguity of the concept of
      consciousness and the difficult issue of its moral significance are then
      examined. The Authors stress the need for longitudinal prognostic studies, the
      promotion of an expert widespread use of standardized behavioural scales, and
      recommend that the ethical debate about VS rely upon the widest consensus of the 
      scientific community.
FAU - Tarquini, Daniela
AU  - Tarquini D
AD  - Neurologa, UOC Neurologia, PTP Nuovo Regina Margherita, Rome, Italy.
      dantarquini@gmail.com
FAU - Congedo, Maria
AU  - Congedo M
FAU - Formaglio, Fabio
AU  - Formaglio F
FAU - Gasparini, Maddalena
AU  - Gasparini M
FAU - Marcello, Norina
AU  - Marcello N
FAU - Porteri, Corinna
AU  - Porteri C
FAU - Pucci, Eugenio
AU  - Pucci E
FAU - Zullo, Silvia
AU  - Zullo S
FAU - Defanti, Carlo A
AU  - Defanti CA
LA  - eng
PT  - Journal Article
DEP - 20111201
PL  - Italy
TA  - Neurol Sci
JT  - Neurological sciences : official journal of the Italian Neurological Society and 
      of the Italian Society of Clinical Neurophysiology
JID - 100959175
SB  - IM
MH  - Consciousness/*ethics/physiology
MH  - *Ethical Analysis
MH  - Humans
MH  - Longitudinal Studies
MH  - Morals
MH  - Persistent Vegetative State/*diagnosis/physiopathology
EDAT- 2011/12/02 06:00
MHDA- 2012/09/26 06:00
CRDT- 2011/12/02 06:00
PHST- 2011/09/10 00:00 [received]
PHST- 2011/11/18 00:00 [accepted]
PHST- 2011/12/02 06:00 [entrez]
PHST- 2011/12/02 06:00 [pubmed]
PHST- 2012/09/26 06:00 [medline]
AID - 10.1007/s10072-011-0867-y [doi]
PST - ppublish
SO  - Neurol Sci. 2012 Jun;33(3):695-700. doi: 10.1007/s10072-011-0867-y. Epub 2011 Dec
      1.


PMID- 22130484
OWN - NLM
STAT- MEDLINE
DCOM- 20120405
LR  - 20191112
IS  - 1868-8551 (Electronic)
IS  - 1868-596X (Linking)
VI  - 28
IP  - 4
DP  - 2011
TI  - A framework program for the teaching of alternative methods (replacement,
      reduction, refinement) to animal experimentation.
PG  - 341-52
AB  - Development of improved communication and education strategies is important to
      make alternatives to the use of animals, and the broad range of applications of
      the 3Rs concept better known and understood by different audiences. For this
      purpose, the Center for Alternatives to Animal Testing in Europe (CAAT-Europe)
      together with the Transatlantic Think Tank for Toxicology (t(4)) hosted a
      three-day workshop on "Teaching Alternative Methods to Animal Experimentation". A
      compilation of the recommendations by a group of international specialists in the
      field is summarized in this report. Initially, the workshop participants
      identified the different audience groups to be addressed and also the
      communication media that may be used. The main outcome of the workshop was a
      framework for a comprehensive educational program. The modular structure of the
      teaching program presented here allows adaptation to different audiences with
      their specific needs; different time schedules can be easily accommodated on this
      basis. The topics cover the 3Rs principle, basic research, toxicological
      applications, method development and validation, regulatory aspects, case studies
      and ethical aspects of 3Rs approaches. This expert consortium agreed to
      generating teaching materials covering all modules and providing them in an open 
      access online repository.
FAU - Daneshian, Mardas
AU  - Daneshian M
AD  - Center for Alternatives to Animal Testing - Europe, University of Konstanz,
      Germany. mardas.daneshian@uni-konstanz.de
FAU - Akbarsha, Mohammad A
AU  - Akbarsha MA
FAU - Blaauboer, Bas
AU  - Blaauboer B
FAU - Caloni, Francesca
AU  - Caloni F
FAU - Cosson, Pierre
AU  - Cosson P
FAU - Curren, Rodger
AU  - Curren R
FAU - Goldberg, Alan
AU  - Goldberg A
FAU - Gruber, Franz
AU  - Gruber F
FAU - Ohl, Frauke
AU  - Ohl F
FAU - Pfaller, Walter
AU  - Pfaller W
FAU - van der Valk, Jan
AU  - van der Valk J
FAU - Vinardell, Pilar
AU  - Vinardell P
FAU - Zurlo, Joanne
AU  - Zurlo J
FAU - Hartung, Thomas
AU  - Hartung T
FAU - Leist, Marcel
AU  - Leist M
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - ALTEX
JT  - ALTEX
JID - 100953980
RN  - 0 (Hazardous Substances)
SB  - IM
MH  - Animal Testing Alternatives/*methods
MH  - Animals
MH  - Curriculum
MH  - Drug and Narcotic Control/legislation & jurisprudence
MH  - Education
MH  - Ethics, Research
MH  - Hazardous Substances/*toxicity
MH  - Public Opinion
MH  - Reproducibility of Results
MH  - *Research Design
EDAT- 2011/12/02 06:00
MHDA- 2012/04/06 06:00
CRDT- 2011/12/02 06:00
PHST- 2011/12/02 06:00 [entrez]
PHST- 2011/12/02 06:00 [pubmed]
PHST- 2012/04/06 06:00 [medline]
AID - 10.14573/altex.2011.4.341 [doi]
PST - ppublish
SO  - ALTEX. 2011;28(4):341-52. doi: 10.14573/altex.2011.4.341.


PMID- 22130483
OWN - NLM
STAT- MEDLINE
DCOM- 20120405
LR  - 20191112
IS  - 1868-8551 (Electronic)
IS  - 1868-596X (Linking)
VI  - 28
IP  - 4
DP  - 2011
TI  - Critical evaluation of the use of dogs in biomedical research and testing in
      Europe.
PG  - 326-40
AB  - Dogs are sometimes referred to as "man's best friend" and with the increase in
      urbanization and lifestyle changes, dogs are seen by their owners as family
      members. Society expresses specific concerns about the experimental use of dogs, 
      as they are sometimes perceived to have a special status for humans. This may
      appear somewhat conflicting with the idea that the intrinsic value of all animals
      is the same, and that also several other animal species are used in biomedical
      research and toxicology. This aspect and many others are discussed in an
      introductory chapter dealing with ethical considerations on the use of dogs as
      laboratory animals. The report gives an overview on the use of dogs in biomedical
      research, safety assessment and the drug developmental process and reflects the
      discussion on the use of dogs as second (non-rodent)species in toxicity testing. 
      Approximately 20,000 dogs are used in scientific procedures in Europe every year,
      and their distinct genetic, physiological and behavioral characteristics may
      support their use as models for e.g. behavioral analysis and genetic research.
      Advances in the 3Rs (Replacement, Reduction and Refinement of experiments using
      dogs) are described, potential opportunities are discussed and recommendations
      for further progress in this area are made.
FAU - Hasiwa, Nina
AU  - Hasiwa N
AD  - Centre for Alternatives to Animal Testing, Europe, University of Konstanz,
      Germany.
FAU - Bailey, Jarrod
AU  - Bailey J
FAU - Clausing, Peter
AU  - Clausing P
FAU - Daneshian, Mardas
AU  - Daneshian M
FAU - Eileraas, Marianne
AU  - Eileraas M
FAU - Farkas, Sandor
AU  - Farkas S
FAU - Gyertyan, Istvan
AU  - Gyertyan I
FAU - Hubrecht, Robert
AU  - Hubrecht R
FAU - Kobel, Werner
AU  - Kobel W
FAU - Krummenacher, Goran
AU  - Krummenacher G
FAU - Leist, Marcel
AU  - Leist M
FAU - Lohi, Hannes
AU  - Lohi H
FAU - Miklosi, Adam
AU  - Miklosi A
FAU - Ohl, Frauke
AU  - Ohl F
FAU - Olejniczak, Klaus
AU  - Olejniczak K
FAU - Schmitt, Georg
AU  - Schmitt G
FAU - Sinnett-Smith, Patrick
AU  - Sinnett-Smith P
FAU - Smith, David
AU  - Smith D
FAU - Wagner, Kristina
AU  - Wagner K
FAU - Yager, James D
AU  - Yager JD
FAU - Zurlo, Joanne
AU  - Zurlo J
FAU - Hartung, Thomas
AU  - Hartung T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - ALTEX
JT  - ALTEX
JID - 100953980
RN  - 0 (Pesticides)
SB  - IM
MH  - Animal Rights
MH  - Animal Use Alternatives/*methods
MH  - Animals
MH  - Animals, Laboratory
MH  - Biomedical Research/ethics/*methods
MH  - Disease Models, Animal
MH  - Dog Diseases/chemically induced/therapy
MH  - Dogs/*physiology
MH  - Drug-Related Side Effects and Adverse Reactions
MH  - Europe
MH  - Pesticides/adverse effects
MH  - Pets
MH  - Veterinary Medicine/methods
EDAT- 2011/12/02 06:00
MHDA- 2012/04/06 06:00
CRDT- 2011/12/02 06:00
PHST- 2011/12/02 06:00 [entrez]
PHST- 2011/12/02 06:00 [pubmed]
PHST- 2012/04/06 06:00 [medline]
AID - 10.14573/altex.2011.4.326 [doi]
PST - ppublish
SO  - ALTEX. 2011;28(4):326-40. doi: 10.14573/altex.2011.4.326.


PMID- 22130444
OWN - NLM
STAT- MEDLINE
DCOM- 20120427
LR  - 20190709
IS  - 1943-4723 (Electronic)
IS  - 0002-8177 (Linking)
VI  - 142
IP  - 12
DP  - 2011 Dec
TI  - What are the ethical ramifications and suggested guidelines when a dental office 
      is confirmed as having an active bedbug infestation?
PG  - 1398-9
FAU - Henner, Kevin A
AU  - Henner KA
AD  - American Dental Association Council on Ethics, Bylaws and Judicial Affairs,
      Chicago, IL 60611, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Am Dent Assoc
JT  - Journal of the American Dental Association (1939)
JID - 7503060
SB  - IM
MH  - Animals
MH  - *Bedbugs
MH  - Beneficence
MH  - Communication
MH  - Dental Offices/*ethics
MH  - Dentist-Patient Relations/ethics
MH  - Ectoparasitic Infestations/*diagnosis
MH  - *Ethics, Dental
MH  - Humans
MH  - *Practice Guidelines as Topic
MH  - Social Justice
MH  - Truth Disclosure
EDAT- 2011/12/02 06:00
MHDA- 2012/04/28 06:00
CRDT- 2011/12/02 06:00
PHST- 2011/12/02 06:00 [entrez]
PHST- 2011/12/02 06:00 [pubmed]
PHST- 2012/04/28 06:00 [medline]
AID - S0002-8177(14)62771-9 [pii]
AID - 10.14219/jada.archive.2011.0144 [doi]
PST - ppublish
SO  - J Am Dent Assoc. 2011 Dec;142(12):1398-9. doi: 10.14219/jada.archive.2011.0144.


PMID- 22130115
OWN - NLM
STAT- MEDLINE
DCOM- 20120210
LR  - 20211021
IS  - 1532-6535 (Electronic)
IS  - 0009-9236 (Linking)
VI  - 91
IP  - 1
DP  - 2012 Jan
TI  - Vaccines against drug abuse.
PG  - 60-70
LID - 10.1038/clpt.2011.281 [doi]
AB  - The currently available medications for the treatment of drug abuse have had only
      limited success. Anti-addiction vaccines, aimed at eliciting antibodies that
      block the pharmacological effects of drugs, have great potential for treating
      drug abuse. We review the status of two vaccines that are undergoing clinical
      trials (for cocaine and nicotine addiction) and two that are still in preclinical
      development (for methamphetamine and heroin addiction). We also outline the
      challenges and ethical concerns associated with the development of anti-addiction
      vaccines and their use as future therapeutics.
FAU - Shen, X Y
AU  - Shen XY
AD  - Immunology Allergy & Rheumatology, Department of Medicine, Baylor College of
      Medicine, Houston, Texas, USA.
FAU - Orson, F M
AU  - Orson FM
FAU - Kosten, T R
AU  - Kosten TR
LA  - eng
GR  - 1X02DA032939/DA/NIDA NIH HHS/United States
GR  - 5R01DA030338/DA/NIDA NIH HHS/United States
GR  - U01 DA023898/DA/NIDA NIH HHS/United States
GR  - P50-DA18197/DA/NIDA NIH HHS/United States
GR  - R01 DA026859/DA/NIDA NIH HHS/United States
GR  - K05 DA 0454/DA/NIDA NIH HHS/United States
GR  - P50 DA018197/DA/NIDA NIH HHS/United States
GR  - R01 DA030338/DA/NIDA NIH HHS/United States
GR  - K05 DA000454/DA/NIDA NIH HHS/United States
GR  - R01DA026859/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20111130
PL  - United States
TA  - Clin Pharmacol Ther
JT  - Clinical pharmacology and therapeutics
JID - 0372741
RN  - 0 (Vaccines)
SB  - IM
MH  - Animals
MH  - Behavior, Addictive/immunology/metabolism/*prevention & control
MH  - Clinical Trials as Topic/methods
MH  - Cocaine-Related Disorders/immunology/metabolism/prevention & control
MH  - Humans
MH  - Substance-Related Disorders/immunology/metabolism/*prevention & control
MH  - Vaccines/administration & dosage/immunology/*therapeutic use
PMC - PMC3345810
MID - NIHMS373901
EDAT- 2011/12/02 06:00
MHDA- 2012/02/11 06:00
CRDT- 2011/12/02 06:00
PHST- 2011/12/02 06:00 [entrez]
PHST- 2011/12/02 06:00 [pubmed]
PHST- 2012/02/11 06:00 [medline]
AID - clpt2011281 [pii]
AID - 10.1038/clpt.2011.281 [doi]
PST - ppublish
SO  - Clin Pharmacol Ther. 2012 Jan;91(1):60-70. doi: 10.1038/clpt.2011.281. Epub 2011 
      Nov 30.


PMID- 22129912
OWN - NLM
STAT- MEDLINE
DCOM- 20120325
LR  - 20211021
IS  - 1643-3750 (Electronic)
IS  - 1234-1010 (Linking)
VI  - 17
IP  - 12
DP  - 2011 Dec
TI  - Medical marijuana: medical necessity versus political agenda.
PG  - RA249-61
AB  - Marijuana is classified by the Drug Enforcement Agency (DEA) as an illegal
      Schedule I drug which has no accepted medical use. However, recent studies have
      shown that medical marijuana is effective in controlling chronic non-cancer pain,
      alleviating nausea and vomiting associated with chemotherapy, treating wasting
      syndrome associated with AIDS, and controlling muscle spasms due to multiple
      sclerosis. These studies state that the alleviating benefits of marijuana
      outweigh the negative effects of the drug, and recommend that marijuana be
      administered to patients who have failed to respond to other therapies. Despite
      supporting evidence, the DEA refuses to reclassify marijuana as a Schedule II
      drug, which would allow physicians to prescribe marijuana to suffering patients. 
      The use of medical marijuana has continued to gain support among states, and is
      currently legal in 16 states and the District of Columbia. This is in stark
      contrast to the federal government's stance of zero-tolerance, which has led to a
      heated legal debate in the United States. After reviewing relevant scientific
      data and grounding the issue in ethical principles like beneficence and
      nonmaleficence, there is a strong argument for allowing physicians to prescribe
      marijuana. Patients have a right to all beneficial treatments and to deny them
      this right violates their basic human rights.
FAU - Clark, Peter A
AU  - Clark PA
AD  - Jesuit Community, St Joseph's University, Philadelphia, PA 19131, USA.
      pclark@sju.edu
FAU - Capuzzi, Kevin
AU  - Capuzzi K
FAU - Fick, Cameron
AU  - Fick C
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and
      clinical research
JID - 9609063
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Cannabis/*chemistry
MH  - Ethics, Medical
MH  - Humans
MH  - Jurisprudence
MH  - Plant Extracts/*therapeutic use
MH  - *Politics
PMC - PMC3628147
EDAT- 2011/12/02 06:00
MHDA- 2012/03/27 06:00
CRDT- 2011/12/02 06:00
PHST- 2011/12/02 06:00 [entrez]
PHST- 2011/12/02 06:00 [pubmed]
PHST- 2012/03/27 06:00 [medline]
AID - 882116 [pii]
AID - 10.12659/msm.882116 [doi]
PST - ppublish
SO  - Med Sci Monit. 2011 Dec;17(12):RA249-61. doi: 10.12659/msm.882116.


PMID- 22129802
OWN - NLM
STAT- MEDLINE
DCOM- 20130820
LR  - 20131121
IS  - 1873-4898 (Electronic)
IS  - 1477-5131 (Linking)
VI  - 9
IP  - 1
DP  - 2013 Feb
TI  - Renal and urological abnormalities occurring with Mullerian anomalies.
PG  - 27-32
LID - 10.1016/j.jpurol.2011.11.003 [doi]
LID - S1477-5131(11)00279-8 [pii]
AB  - OBJECTIVE: To describe the spectrum and frequency of renal and urological
      abnormalities in a cohort of patients with uterine anomalies. MATERIAL AND
      METHODS: We conducted an ethics committee approved review of 164 women referred
      to the imaging department from a specialist gynaecological anomaly clinic.
      Imaging acquired over 8 years was assessed and this was sufficient for assessment
      of the morphology of the gynaecological and renal tracts in 113 patients.
      RESULTS: Absent unilateral kidney was the most common abnormality (31.8%), most
      frequent in Type 3 uterine anomalies. Absent kidneys occurred in other anomaly
      types at lower frequency. Pelvic ureteric remnants were found in 9 of 36 patients
      with absent kidneys; these inserted ectopically, most commonly into the vagina.
      Urological abnormalities were found in 11 patients with two kidneys, including
      ectopic ureters, scarred kidneys and dysplastic kidney. Obstructed hemivaginas
      were associated commonly but not invariably with an absent kidney. CONCLUSION:
      Previously unreported renal and urological abnormalities have been described in
      patients with congenital uterine anomalies. These have significant clinical
      impact. Ectopic ureters can cause incontinence, and potentially cause pain and
      become infected. Knowledge of the ureteric course, including ureteric remnants,
      is essential before complex laparoscopic and vaginal surgery.
CI  - Copyright (c) 2011 Journal of Pediatric Urology Company. Published by Elsevier
      Ltd. All rights reserved.
FAU - Hall-Craggs, Margaret A
AU  - Hall-Craggs MA
AD  - Department of Imaging, University College Hospital London NHS Trust, 235 Euston
      Road, London NW1 2BU, United Kingdom. margaret.hall-craggs@uclh.nhs.uk
FAU - Kirkham, Alex
AU  - Kirkham A
FAU - Creighton, Sarah M
AU  - Creighton SM
LA  - eng
GR  - Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111129
PL  - England
TA  - J Pediatr Urol
JT  - Journal of pediatric urology
JID - 101233150
RN  - Mullerian aplasia
SB  - IM
MH  - 46, XX Disorders of Sex Development
MH  - Abnormalities, Multiple/epidemiology/*pathology/*surgery
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Congenital Abnormalities
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Kidney/abnormalities/pathology/surgery
MH  - Magnetic Resonance Imaging
MH  - Menstruation Disturbances/epidemiology/*pathology/*surgery
MH  - Middle Aged
MH  - Mullerian Ducts/abnormalities/pathology/surgery
MH  - Pelvic Pain/epidemiology/pathology/surgery
MH  - Postoperative Complications/prevention & control
MH  - *Reconstructive Surgical Procedures
MH  - Somites/abnormalities/pathology/surgery
MH  - Spine/abnormalities/pathology/surgery
MH  - Uterus/abnormalities/pathology/surgery
MH  - Vagina/abnormalities/pathology/surgery
MH  - Young Adult
EDAT- 2011/12/02 06:00
MHDA- 2013/08/21 06:00
CRDT- 2011/12/02 06:00
PHST- 2011/05/04 00:00 [received]
PHST- 2011/11/05 00:00 [accepted]
PHST- 2011/12/02 06:00 [entrez]
PHST- 2011/12/02 06:00 [pubmed]
PHST- 2013/08/21 06:00 [medline]
AID - S1477-5131(11)00279-8 [pii]
AID - 10.1016/j.jpurol.2011.11.003 [doi]
PST - ppublish
SO  - J Pediatr Urol. 2013 Feb;9(1):27-32. doi: 10.1016/j.jpurol.2011.11.003. Epub 2011
      Nov 29.


PMID- 22129463
OWN - NLM
STAT- MEDLINE
DCOM- 20120813
LR  - 20220408
IS  - 1601-0825 (Electronic)
IS  - 1354-523X (Linking)
VI  - 18
IP  - 3
DP  - 2012 Apr
TI  - Genome technologies and personalized dental medicine.
PG  - 223-35
LID - 10.1111/j.1601-0825.2011.01876.x [doi]
AB  - The addition of genomic information to our understanding of oral disease is
      driving important changes in oral health care. It is anticipated that
      genome-derived information will promote a deeper understanding of disease
      etiology and permit earlier diagnosis, allowing for preventative measures prior
      to disease onset rather than treatment that attempts to repair the diseased
      state. Advances in genome technologies have fueled expectations for this
      proactive healthcare approach. Application of genomic testing is expanding and
      has already begun to find its way into the practice of clinical dentistry. To
      take full advantage of the information and technologies currently available, it
      is vital that dental care providers, consumers, and policymakers be aware of
      genomic approaches to understanding of oral diseases and the application of
      genomic testing to disease diagnosis and treatment. Ethical, legal, clinical, and
      educational initiatives are also required to responsibly incorporate genomic
      information into the practice of dentistry. This article provides an overview of 
      the application of genomic technologies to oral health care and introduces issues
      that require consideration if we are to realize the full potential of genomics to
      enable the practice of personalized dental medicine.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Eng, G
AU  - Eng G
AD  - Institute for Genome Sciences & Policy, Duke University, Durham, NC 27708, USA.
FAU - Chen, A
AU  - Chen A
FAU - Vess, T
AU  - Vess T
FAU - Ginsburg, G S
AU  - Ginsburg GS
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111201
PL  - Denmark
TA  - Oral Dis
JT  - Oral diseases
JID - 9508565
MH  - Computational Biology
MH  - *Dental Care
MH  - Genetic Techniques
MH  - Genetic Testing
MH  - Genome, Human/*genetics
MH  - Humans
MH  - Mouth Diseases/genetics/prevention & control
MH  - *Personal Health Services
MH  - *Precision Medicine
MH  - Tooth Diseases/genetics/prevention & control
EDAT- 2011/12/02 06:00
MHDA- 2012/08/14 06:00
CRDT- 2011/12/02 06:00
PHST- 2011/12/02 06:00 [entrez]
PHST- 2011/12/02 06:00 [pubmed]
PHST- 2012/08/14 06:00 [medline]
AID - 10.1111/j.1601-0825.2011.01876.x [doi]
PST - ppublish
SO  - Oral Dis. 2012 Apr;18(3):223-35. doi: 10.1111/j.1601-0825.2011.01876.x. Epub 2011
      Dec 1.


PMID- 22128585
OWN - NLM
STAT- MEDLINE
DCOM- 20120104
LR  - 20111201
IS  - 1351-5578 (Print)
IS  - 1351-5578 (Linking)
VI  - 19
IP  - 1
DP  - 2011
TI  - Reflexivity in a study of family carers in home palliative care: a personal
      account.
PG  - 30-6
AB  - AIM: To discuss a personal account of the role of reflexivity in a qualitative,
      grounded theory study with family carers in home palliative care. BACKGROUND: The
      study explored the experience of carers of family members dying at home using
      semi-structured interviews before and after the death. It focused on carers'
      expectations and preparedness for the dying process. The findings suggested that 
      carers play a leading role in a drama but there are no rehearsals because they
      have not been in this role before. They also have no script because they find it 
      hard to read about the dying process. Consequently they feel anxious, uncertain
      and unprepared. They have direction from professionals and support from paid
      carers, but have mixed experiences of these services. Hence the research setting 
      was charged with emotion and presented particular ethical challenges. DISCUSSION:
      Reflexivity is an important component of qualitative inquiry. It involves
      constant attention to the researcher's perspective, background and influence on
      the research process and the effects this has on the researcher, which may affect
      the research. Reflexivity was a prominent thread throughout my study, involving
      epistemological and personal aspects. It focused on my performance as researcher 
      and the role of empathy and reciprocity in the researcher-participant
      relationship. The potential for therapeutic change for research participants was 
      seen as beneficial, but it could cause conflict between my roles as nurse and
      researcher and risk of exploiting participants. Reflexivity also involved
      exploration of the emotional impact of doing the research and implications of the
      research setting. CONCLUSION: Reflexivity was an essential and dynamic component 
      of this study, which involved constant interplay between the author and the
      research.
FAU - Newbury, Jenny
AU  - Newbury J
AD  - Dorothy House Hospice, Winsley, Wiltshire, UK. jenny.newbury@btinternet.com
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurse Res
JT  - Nurse researcher
JID - 9435953
MH  - *Attitude to Death
MH  - Caregivers/*psychology
MH  - Empathy
MH  - Humans
MH  - Nursing Methodology Research/*ethics
MH  - Palliative Care/*methods
MH  - Researcher-Subject Relations/*ethics
EDAT- 2011/12/02 06:00
MHDA- 2012/01/05 06:00
CRDT- 2011/12/02 06:00
PHST- 2011/12/02 06:00 [entrez]
PHST- 2011/12/02 06:00 [pubmed]
PHST- 2012/01/05 06:00 [medline]
AID - 10.7748/nr2011.10.19.1.30.c8769 [doi]
PST - ppublish
SO  - Nurse Res. 2011;19(1):30-6. doi: 10.7748/nr2011.10.19.1.30.c8769.


PMID- 22128583
OWN - NLM
STAT- MEDLINE
DCOM- 20120104
LR  - 20131106
IS  - 1351-5578 (Print)
IS  - 1351-5578 (Linking)
VI  - 19
IP  - 1
DP  - 2011
TI  - Employing an ethnographic approach: key characteristics.
PG  - 17-24
AB  - AIM: Nurses are increasingly embracing ethnography as a useful research
      methodology. This paper presents an overview of some of the main characteristics 
      we considered and the challenges encountered when using ethnography to explore
      the nature of communication between children and health professionals in a
      children's hospital. BACKGROUND: There is no consensual definition or single
      procedure to follow when using ethnography. This is largely attributable to the
      re-contextualisation of ethnography over time through diversification in and
      across many disciplines. Thus, it is imperative to consider some of ethnography's
      trademark features. DATA SOURCES: To identify core trademark features of
      ethnography, we collated data following a scoping review of pertinent
      ethnographic textbooks, journal articles, attendance at ethnographic workshops
      and discussions with principle ethnographers. REVIEW METHODS: This is a
      methodological paper. DISCUSSION: Essentially, ethnography is a field-orientated 
      activity that has cultural interpretations at its core, although the levels of
      those interpretations vary. We identified six trademark features to be considered
      when embracing an ethnographic approach: naturalism; context; multiple data
      sources; small case numbers; 'emic' and 'etic' perspectives, and ethical
      considerations. CONCLUSION: Ethnography has an assortment of meanings, so it is
      not often used in a wholly orthodox way and does not fall under the auspices of
      one epistemological belief. Yet, there are core criteria and trademark features
      that researchers should take into account alongside their particular
      epistemological beliefs when embracing an ethnographic inquiry. IMPLICATIONS FOR 
      PRACTICE/RESEARCH: We hope this paper promotes a clearer vision of the
      methodological processes to consider when embarking on ethnography and creates an
      avenue for others to disseminate their experiences of and challenges encountered 
      when applying ethnography's trademark features in different healthcare contexts.
FAU - Lambert, Veronica
AU  - Lambert V
AD  - School of Nursing, Dublin City University, Dublin, Ireland.
      Veronica.Lambert@dcu.ie
FAU - Glacken, Michele
AU  - Glacken M
FAU - McCarron, Mary
AU  - McCarron M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurse Res
JT  - Nurse researcher
JID - 9435953
CIN - Nurse Res. 2011;19(1):4-5. PMID: 22128580
MH  - Anthropology, Cultural/*methods
MH  - *Cultural Characteristics
MH  - Humans
MH  - Nursing Methodology Research/*methods
EDAT- 2011/12/02 06:00
MHDA- 2012/01/05 06:00
CRDT- 2011/12/02 06:00
PHST- 2011/12/02 06:00 [entrez]
PHST- 2011/12/02 06:00 [pubmed]
PHST- 2012/01/05 06:00 [medline]
AID - 10.7748/nr2011.10.19.1.17.c8767 [doi]
PST - ppublish
SO  - Nurse Res. 2011;19(1):17-24. doi: 10.7748/nr2011.10.19.1.17.c8767.


PMID- 22128100
OWN - NLM
STAT- MEDLINE
DCOM- 20120319
LR  - 20181201
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 6
DP  - 2011 Nov
TI  - Ethical concerns of reviewers: more issues.
PG  - 862
LID - 10.1177/0969733011401124 [doi]
FAU - Wiwanitkit, Viroj
AU  - Wiwanitkit V
LA  - eng
PT  - Letter
PT  - Comment
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
CON - Nurs Ethics. 2010 Nov;17(6):741-8. PMID: 21097972
MH  - *Attitude of Health Personnel
MH  - Female
MH  - Humans
MH  - Male
MH  - Nursing Research/*ethics
MH  - Peer Review, Research/*ethics
MH  - Periodicals as Topic/*ethics
EDAT- 2011/12/01 06:00
MHDA- 2012/03/20 06:00
CRDT- 2011/12/01 06:00
PHST- 2011/12/01 06:00 [entrez]
PHST- 2011/12/01 06:00 [pubmed]
PHST- 2012/03/20 06:00 [medline]
AID - 18/6/862 [pii]
AID - 10.1177/0969733011401124 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Nov;18(6):862. doi: 10.1177/0969733011401124.


PMID- 22128098
OWN - NLM
STAT- MEDLINE
DCOM- 20120319
LR  - 20111130
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 6
DP  - 2011 Nov
TI  - Keeping research ethics under review.
PG  - 751-2
LID - 10.1177/0969733011425298 [doi]
FAU - Gallagher, Ann
AU  - Gallagher A
LA  - eng
PT  - Editorial
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - *Ethical Review
MH  - Humans
MH  - Nursing Research/*ethics
EDAT- 2011/12/01 06:00
MHDA- 2012/03/20 06:00
CRDT- 2011/12/01 06:00
PHST- 2011/12/01 06:00 [entrez]
PHST- 2011/12/01 06:00 [pubmed]
PHST- 2012/03/20 06:00 [medline]
AID - 18/6/751 [pii]
AID - 10.1177/0969733011425298 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Nov;18(6):751-2. doi: 10.1177/0969733011425298.


PMID- 22127003
OWN - NLM
STAT- MEDLINE
DCOM- 20120418
LR  - 20111130
IS  - 1031-3613 (Print)
IS  - 1031-3613 (Linking)
VI  - 23
IP  - 8
DP  - 2011
TI  - Computational modelling of maternal interactions with spermatozoa: potentials and
      prospects.
PG  - 976-89
LID - 10.1071/RD11032 [doi]
AB  - Understanding the complex interactions between gametes, embryos and the maternal 
      tract is required knowledge for combating infertility and developing new methods 
      of contraception. Here we present some main aspects of spermatozoa interactions
      with the mammalian oviduct before fertilisation and discuss how computational
      modelling can be used as an invaluable aid to experimental investigation in this 
      field. A complete predictive computational model of gamete and embryo
      interactions with the female reproductive tract is a long way off. However, the
      enormity of this task should not discourage us from working towards it.
      Computational modelling allows us to investigate aspects of maternal
      communication with gametes and embryos, which are financially, ethically or
      practically difficult to look at experimentally. In silico models of maternal
      communication with gametes and embryos can be used as tools to complement in vivo
      experiments, in the same way as in vitro and in situ models.
FAU - Burkitt, Mark
AU  - Burkitt M
AD  - The Department of Computer Science, University of Sheffield, Sheffield, Regent
      Court, 211 Portobello, Sheffield S1 4DP, UK.
FAU - Walker, Dawn
AU  - Walker D
FAU - Romano, Daniela M
AU  - Romano DM
FAU - Fazeli, Alireza
AU  - Fazeli A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Australia
TA  - Reprod Fertil Dev
JT  - Reproduction, fertility, and development
JID - 8907465
SB  - IM
MH  - Animals
MH  - *Computer Simulation
MH  - Embryo, Mammalian/physiology
MH  - Female
MH  - Fertilization/physiology
MH  - Humans
MH  - Male
MH  - *Models, Biological
MH  - Oocytes/physiology
MH  - Oviducts/*physiology
MH  - Pregnancy
MH  - Spermatozoa/*physiology
EDAT- 2011/12/01 06:00
MHDA- 2012/04/19 06:00
CRDT- 2011/12/01 06:00
PHST- 2011/02/04 00:00 [received]
PHST- 2011/07/12 00:00 [accepted]
PHST- 2011/12/01 06:00 [entrez]
PHST- 2011/12/01 06:00 [pubmed]
PHST- 2012/04/19 06:00 [medline]
AID - RD11032 [pii]
AID - 10.1071/RD11032 [doi]
PST - ppublish
SO  - Reprod Fertil Dev. 2011;23(8):976-89. doi: 10.1071/RD11032.


PMID- 22126892
OWN - NLM
STAT- MEDLINE
DCOM- 20130903
LR  - 20191210
IS  - 1872-7565 (Electronic)
IS  - 0169-2607 (Linking)
VI  - 109
IP  - 2
DP  - 2013 Feb
TI  - Validation of subject-specific cardiovascular system models from porcine
      measurements.
PG  - 197-210
LID - 10.1016/j.cmpb.2011.10.013 [doi]
LID - S0169-2607(11)00301-4 [pii]
AB  - A previously validated mathematical model of the cardiovascular system (CVS) is
      made subject-specific using an iterative, proportional gain-based identification 
      method. Prior works utilised a complete set of experimentally measured data that 
      is not clinically typical or applicable. In this paper, parameters are identified
      using proportional gain-based control and a minimal, clinically available set of 
      measurements. The new method makes use of several intermediary steps through
      identification of smaller compartmental models of CVS to reduce the number of
      parameters identified simultaneously and increase the convergence stability of
      the method. This new, clinically relevant, minimal measurement approach is
      validated using a porcine model of acute pulmonary embolism (APE). Trials were
      performed on five pigs, each inserted with three autologous blood clots of
      decreasing size over a period of four to five hours. All experiments were
      reviewed and approved by the Ethics Committee of the Medical Faculty at the
      University of Liege, Belgium. Continuous aortic and pulmonary artery pressures
      (P(ao), P(pa)) were measured along with left and right ventricle pressure and
      volume waveforms. Subject-specific CVS models were identified from global end
      diastolic volume (GEDV), stroke volume (SV), P(ao), and P(pa) measurements, with 
      the mean volumes and maximum pressures of the left and right ventricles used to
      verify the accuracy of the fitted models. The inputs (GEDV, SV, P(ao), P(pa))
      used in the identification process were matched by the CVS model to errors <0.5%.
      Prediction of the mean ventricular volumes and maximum ventricular pressures not 
      used to fit the model compared experimental measurements to median absolute
      errors of 4.3% and 4.4%, which are equivalent to the measurement errors of
      currently used monitoring devices in the ICU ( approximately 5-10%). These
      results validate the potential for implementing this approach in the intensive
      care unit.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Revie, James A
AU  - Revie JA
AD  - Department of Mechanical Engineering, Centre of Bioengineering, University of
      Canterbury, Christchurch, New Zealand. james.revie@pg.canterbury.ac.nz
FAU - Stevenson, David J
AU  - Stevenson DJ
FAU - Chase, J Geoffrey
AU  - Chase JG
FAU - Hann, Christopher E
AU  - Hann CE
FAU - Lambermont, Bernard C
AU  - Lambermont BC
FAU - Ghuysen, Alexandre
AU  - Ghuysen A
FAU - Kolh, Philippe
AU  - Kolh P
FAU - Shaw, Geoffrey M
AU  - Shaw GM
FAU - Heldmann, Stefan
AU  - Heldmann S
FAU - Desaive, Thomas
AU  - Desaive T
LA  - eng
PT  - Journal Article
PT  - Validation Study
DEP - 20111127
PL  - Ireland
TA  - Comput Methods Programs Biomed
JT  - Computer methods and programs in biomedicine
JID - 8506513
SB  - IM
MH  - Algorithms
MH  - Animal Experimentation
MH  - Animals
MH  - *Cardiovascular Physiological Phenomena
MH  - *Cardiovascular System
MH  - *Models, Anatomic
MH  - *Models, Cardiovascular
MH  - New Zealand
MH  - Sus scrofa
EDAT- 2011/12/01 06:00
MHDA- 2013/09/04 06:00
CRDT- 2011/12/01 06:00
PHST- 2011/03/17 00:00 [received]
PHST- 2011/09/26 00:00 [revised]
PHST- 2011/10/25 00:00 [accepted]
PHST- 2011/12/01 06:00 [entrez]
PHST- 2011/12/01 06:00 [pubmed]
PHST- 2013/09/04 06:00 [medline]
AID - S0169-2607(11)00301-4 [pii]
AID - 10.1016/j.cmpb.2011.10.013 [doi]
PST - ppublish
SO  - Comput Methods Programs Biomed. 2013 Feb;109(2):197-210. doi:
      10.1016/j.cmpb.2011.10.013. Epub 2011 Nov 27.


PMID- 22126577
OWN - NLM
STAT- MEDLINE
DCOM- 20120730
LR  - 20170308
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Linking)
VI  - 12
IP  - 7
DP  - 2011
TI  - Diagnostic and prognostic significance of prostate specific antigen and serum
      interleukin 18 and 10 in patients with locally advanced prostate cancer: a
      prospective study.
PG  - 1843-8
AB  - BACKGROUND: Prostate cancer is one of the most common cancers afflicting men
      today. Prostate biopsy, an invasive procedure is generally used for diagnoses but
      attempts are being made to find accurate and precise non-invasive biomarkers.
      Diagnostic accuracy of prostate specific antigen (PSA) has been well documented. 
      Serum interleukin-18 (IL-18) and interleukin-10 (IL-10) have shown their
      diagnostic ability in other cancers but not investigated well in prostate cancer.
      This study, thus determines the diagnostic and prognostic significance of PSA,
      IL-18 and IL-10 prospectively in patients with carcinoma prostate. METHODS: A
      total of 149 patients, aged 40-84 yrs were investigated during April 2007 to July
      2010 and recruited for this study after Institutional ethical approval. Of the
      total of 149 patients, 71 had biopsy proven prostate cancers (TNM stage: T2=17,
      T3=26 and T4=28) and 78 clinical benign prostate hyperplasia (BPH). Peripheral
      blood samples of all patients and 71 age matched control subjects were obtained
      at baseline and estimation of PSA, IL-18 and IL-10 was done by enzyme linked
      immunosorbent assay (ELISA). Carcinoma prostate patients were followed for three 
      years. Data were analyzed with ANOVA, ROC curve analysis and survival analysis.
      RESULTS: The baseline levels of PSA, IL-18 and IL-10 in all groups of carcinoma
      prostate were found to be significantly (p<0.01) higher than both Control and
      BPH. The levels of IL-18 and IL-10 also found to be elevated significantly in
      stage T3 (p<0.05) and T4 (p<0.01) as compared to stage T2. The levels especially 
      of IL-18 is found to be well associated with progression of the disease of
      various groups (r=0.84, p<0.01). In contrast, IL-10 showed significant direct
      association with progression of carcinoma (r=0.84, p<0.01) while inverse relation
      with survival duration (r=-0.48, p<0.01) and survival rate (chi2=8.98, p=0.0027; 
      Hazard ratio=0.37, 95% CI=0.18-0.69). CONCLUSIONS: Study concluded that serum
      IL-18 has potential to be a better diagnostic marker with higher specificity and 
      sensitivity and IL-10 may be valuable as a prognostic marker than PSA in
      carcinoma prostate.
FAU - Dwivedi, Shailendra
AU  - Dwivedi S
AD  - Department of Pharmacology and Therapeutics, Chhatrapati Sahuji Maharaj Medical
      University (Erstwhile KGMU), Lucknow, India.
FAU - Goel, Apul
AU  - Goel A
FAU - Natu, Shanker M
AU  - Natu SM
FAU - Mandhani, Anil
AU  - Mandhani A
FAU - Khattri, Sanjay
AU  - Khattri S
FAU - Pant, Kamlesh K
AU  - Pant KK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Interleukin-18)
RN  - 130068-27-8 (Interleukin-10)
RN  - EC 3.4.21.77 (Prostate-Specific Antigen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/blood
MH  - Disease Progression
MH  - Humans
MH  - Interleukin-10/*blood
MH  - Interleukin-18/*blood
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Prospective Studies
MH  - Prostate/pathology
MH  - Prostate-Specific Antigen/*blood
MH  - Prostatic Hyperplasia/blood/*diagnosis/pathology
MH  - Prostatic Neoplasms/blood/*diagnosis/pathology
MH  - Sensitivity and Specificity
EDAT- 2011/12/01 06:00
MHDA- 2012/07/31 06:00
CRDT- 2011/12/01 06:00
PHST- 2011/12/01 06:00 [entrez]
PHST- 2011/12/01 06:00 [pubmed]
PHST- 2012/07/31 06:00 [medline]
PST - ppublish
SO  - Asian Pac J Cancer Prev. 2011;12(7):1843-8.


PMID- 22126350
OWN - NLM
STAT- MEDLINE
DCOM- 20120411
LR  - 20121115
IS  - 1834-7819 (Electronic)
IS  - 0045-0421 (Linking)
VI  - 56
IP  - 4
DP  - 2011 Dec
TI  - Clinical evaluation of non-carious cervical lesion restorations using a HEMA-free
      adhesive: three-year results.
PG  - 401-5
LID - 10.1111/j.1834-7819.2011.01370.x [doi]
AB  - BACKGROUND: The use of all-in-one resin-based adhesives in clinical practice has 
      continued to increase. The aim of this study was to evaluate retention and
      marginal staining of a HEMA-free all-in-one adhesive Go! (SDI, Australia) and Ice
      resin composite in non-carious cervical lesions (NCCLs). METHODS: Forty-one
      restorations were placed in 13 patients (age range 44-72 years). Human Ethics
      Committee approval from the University of Melbourne and Dental Health Services
      Victoria was obtained. Restorations were bonded and placed according to the
      manufacturer's instructions. Enamel etching was performed on NCCL margins after
      cleaning with pumice and water. Patients were recalled at six months and one, two
      and three years. Restorations were evaluated for retention and marginal staining,
      and photographic records of restorations were obtained. RESULTS: At three years, 
      six patients were available for recall with 23 restoration sites reviewed. At the
      six-month recall, three restorations had been lost, with a further two lost at
      two years. At three years, an overall cumulative retention rate of 85% was
      calculated using survival analysis. Fifteen of the 23 restorations showed slight 
      marginal staining. CONCLUSIONS: At three years, the overall retention rate of 85%
      indicates a satisfactory result for this new adhesive. Marginal staining was
      regarded as minimal.
CI  - (c) 2011 Australian Dental Association.
FAU - Burrow, M F
AU  - Burrow MF
AD  - Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital,
      Sai Ying Pun, Hong Kong. mfburr58@hku.hk
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Aust Dent J
JT  - Australian dental journal
JID - 0370612
RN  - 0 (Composite Resins)
RN  - 0 (Dentin-Bonding Agents)
RN  - 0 (Go self-etching primer)
RN  - 0 (Methacrylates)
RN  - 0 (Resin Cements)
RN  - 6E1I4IV47V (hydroxyethyl methacrylate)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Composite Resins
MH  - Dental Restoration, Permanent/*methods
MH  - Dentin-Bonding Agents
MH  - Humans
MH  - Methacrylates
MH  - Middle Aged
MH  - *Resin Cements/chemistry
MH  - Survival Analysis
MH  - Tooth Abrasion/therapy
MH  - *Tooth Cervix
EDAT- 2011/12/01 06:00
MHDA- 2012/04/12 06:00
CRDT- 2011/12/01 06:00
PHST- 2011/12/01 06:00 [entrez]
PHST- 2011/12/01 06:00 [pubmed]
PHST- 2012/04/12 06:00 [medline]
AID - 10.1111/j.1834-7819.2011.01370.x [doi]
PST - ppublish
SO  - Aust Dent J. 2011 Dec;56(4):401-5. doi: 10.1111/j.1834-7819.2011.01370.x.


PMID- 29443311
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2163-0402 (Print)
IS  - 2163-0402 (Linking)
VI  - 1
IP  - 1
DP  - 2011 Dec
TI  - Amyotrophic lateral sclerosis: Ethical challenges.
PG  - 2-3
LID - 10.1212/CPJ.0b013e31823fdda2 [doi]
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Neurol Clin Pract
JT  - Neurology. Clinical practice
JID - 101577149
PMC - PMC5766172
EDAT- 2011/12/01 00:00
MHDA- 2011/12/01 00:01
CRDT- 2018/02/15 06:00
PHST- 2018/02/15 06:00 [entrez]
PHST- 2011/12/01 00:00 [pubmed]
PHST- 2011/12/01 00:01 [medline]
AID - 10.1212/CPJ.0b013e31823fdda2 [doi]
AID - 1586158-201112000-00002 [pii]
PST - ppublish
SO  - Neurol Clin Pract. 2011 Dec;1(1):2-3. doi: 10.1212/CPJ.0b013e31823fdda2.


PMID- 27840660
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1765-4629 (Print)
IS  - 1765-4629 (Linking)
VI  - 8
IP  - 4
DP  - 2011 Dec 1
TI  - [PMTCT in Benin: Is the pregnant women's consent free and informed?]
PG  - 173-179
AB  - INTRODUCTION: In international and national HIV/AIDS policies, free and informed 
      consent is recognized as one of the major components of testing programs. For
      pregnant women, free and informed consent means that they should get information 
      on prevention of mother-to-child transmission (PMTCT), understand them and make
      an independent choice after weighing the risks and advantages. However, no PMTCT 
      program looked into the issue of consent. The objective of this paper is to
      explore the free and informed nature of pregnant women's consent with regard to
      testing and their rationale for accepting to be tested. METHODS: We used data
      collected within the framework of the analysis of the creation of the PMTCT
      program in Benin. This analysis is based on multiple case studies that covered
      six maternity homes selected from 56 operational sites. For the specific analysis
      of consent, we used both survey data and qualitative research data. FINDINGS:
      Apart from three cases of secret testing, the free nature of the consent to the
      test is respected on the PMTCT sites. Twenty-nine cases of refusal were recorded.
      The reasons put forth by most pregnant women include the fear of a positive test 
      and its consequences on family life in 55.2% of cases and the expectation of
      their husbands' agreement or disagreement in 27.6% of cases. On the whole, the
      consent was free on all the sites but its informed nature is less respected.
FAU - Kedote, N M
AU  - Kedote NM
AD  - Institut des sciences biomedicales appliquees, 03 BP 3975, Cotonou, Benin.
FAU - Brousselle, A
AU  - Brousselle A
AD  - Universite de Sherbrooke, centre de recherche HCLM, campus Longueuil, 150, place 
      Charles-LeMoyne, bureau 200, CP 11, Longueuil (Qc) J4K-0A8, Canada.
FAU - Champagne, F
AU  - Champagne F
AD  - Universite de Montreal, institut de recherche en sante publique (IRSPUM), 1420
      Mont-Royal boulevard, room 2392, Outremont (QC) H2V 4P3, Canada.
FAU - Laudy, D
AU  - Laudy D
AD  - Universite de Montreal, departement de chirurgie, pavillon Roger-Gaudry, room S
      316, C.P. 6128, succursale Centre-ville, Montreal (QC) H3C 3J7, Canada.
LA  - fre
GR  - 30284-1/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - English Abstract
TT  - Prevention de la transmission mere-enfant du VIH/sida au Benin: le consentement
      des femmes au depistage est-il libre et eclaire ?
PL  - France
TA  - Ethique Sante
JT  - Ethique & sante
JID - 9885754
PMC - PMC5104565
MID - CAMS2538
OTO - NOTNLM
OT  - Benin
OT  - Consent
OT  - Ethics
OT  - HIV/AIDS
OT  - Human right
OT  - Sub-Saharan Africa
EDAT- 2011/12/01 00:00
MHDA- 2011/12/01 00:01
CRDT- 2016/11/15 06:00
PHST- 2016/11/15 06:00 [entrez]
PHST- 2011/12/01 00:00 [pubmed]
PHST- 2011/12/01 00:01 [medline]
AID - 10.1016/j.etiqe.2011.07.003 [doi]
PST - ppublish
SO  - Ethique Sante. 2011 Dec 1;8(4):173-179. doi: 10.1016/j.etiqe.2011.07.003.


PMID- 25865377
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150929
LR  - 20150413
IS  - 1608-5906 (Print)
IS  - 1608-5906 (Linking)
VI  - 10
IP  - 4
DP  - 2011 Dec
TI  - The ethical and legal regulation of HIV-vaccine research in Africa: lessons from 
      Cameroon, Malawi, Nigeria, Rwanda and Zambia.
PG  - 451-63
LID - 10.2989/16085906.2011.646660 [doi]
AB  - Ethical and legal frameworks are important for ensuring that the goals of
      scientific research are realised while at the same time the rights and welfare of
      human participants are adequately protected. A balance in attaining these two
      goals can be achieved if such frameworks provide for legally binding structures
      and processes to oversee, regulate, and monitor research on human participants
      according to accepted norms and standards. From 2007 to 2009, an ethical/legal
      audit, sponsored by the WHO/UNAIDS Ethics, Law and Human Rights Working Group of 
      the African AIDS Vaccine Programme (AAVP ELH), was conducted in regard to five
      African countries (Cameroon, Malawi, Nigeria, Rwanda and Zambia) to determine
      whether these countries have adequate laws, ethical guidelines and policies in
      place to regulate HIV-vaccine research. This article discusses the findings of
      the audit with a view to highlighting key lessons that can be learnt from these
      countries. The article provides the context of the audit by highlighting its
      rationale, aims and methods. We discuss the general findings of the audit and the
      complex issues arising from HIV-vaccine research, specifically. Lastly, we
      propose specific ways in which the ethical/legal frameworks guiding research with
      human participants in these countries can be improved.
FAU - Andanda, Pamela
AU  - Andanda P
AD  - a University of the Witwatersrand , Private Bag 3, Wits 2050 , Johannesburg ,
      South Africa.
FAU - Awah, Paschal
AU  - Awah P
FAU - Ndebele, Paul
AU  - Ndebele P
FAU - Onigbogi, Olanrewaju
AU  - Onigbogi O
FAU - Udatinya, Daniel
AU  - Udatinya D
FAU - Mwondela, Malala
AU  - Mwondela M
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - Afr J AIDS Res
JT  - African journal of AIDS research : AJAR
JID - 101146510
OTO - NOTNLM
OT  - Africa
OT  - HIV/AIDS
OT  - clinical trials
OT  - country profiles
OT  - ethics
OT  - guidelines
OT  - health research
OT  - legislation
OT  - policy
EDAT- 2011/12/01 00:00
MHDA- 2011/12/01 00:01
CRDT- 2015/04/14 06:00
PHST- 2015/04/14 06:00 [entrez]
PHST- 2011/12/01 00:00 [pubmed]
PHST- 2011/12/01 00:01 [medline]
AID - 10.2989/16085906.2011.646660 [doi]
PST - ppublish
SO  - Afr J AIDS Res. 2011 Dec;10(4):451-63. doi: 10.2989/16085906.2011.646660.


PMID- 24836626
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140520
LR  - 20220408
IS  - 1947-5535 (Print)
IS  - 1947-5543 (Linking)
VI  - 9
IP  - 4
DP  - 2011 Dec
TI  - What are the most oppressing legal and ethical issues facing biorepositories and 
      what are some strategies to address them?
PG  - 317-9
LID - 10.1089/bio.2011.9403 [doi]
FAU - Grizzle, William E
AU  - Grizzle WE
FAU - Knoppers, Bartha M
AU  - Knoppers BM
FAU - Zeps, Nikolajs
AU  - Zeps N
FAU - Hewitt, Stephen M
AU  - Hewitt SM
FAU - Sullivan, Karen
AU  - Sullivan K
LA  - eng
GR  - P30 CA013148/CA/NCI NIH HHS/United States
GR  - P50 CA089019/CA/NCI NIH HHS/United States
GR  - P50 CA101955/CA/NCI NIH HHS/United States
GR  - U01 CA044968/CA/NCI NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Biopreserv Biobank
JT  - Biopreservation and biobanking
JID - 101507284
PMC - PMC4275773
EDAT- 2011/12/01 00:00
MHDA- 2011/12/01 00:01
CRDT- 2014/05/20 06:00
PHST- 2014/05/20 06:00 [entrez]
PHST- 2011/12/01 00:00 [pubmed]
PHST- 2011/12/01 00:01 [medline]
AID - 10.1089/bio.2011.9403 [doi]
PST - ppublish
SO  - Biopreserv Biobank. 2011 Dec;9(4):317-9. doi: 10.1089/bio.2011.9403.


PMID- 24826027
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140514
LR  - 20211021
IS  - 0976-0105 (Print)
IS  - 0976-0113 (Linking)
VI  - 3
IP  - 1
DP  - 2011 Dec
TI  - "Does organizational culture influence the ethical behavior in the pharmaceutical
      industry?".
PG  - 219-23
AB  - Study of ethical behavior among medical representatives in the profession is an
      under-portrayed component that deserves further perusal in the pharmaceutical
      industry. The purpose of this study is to find out the influence of
      organizational culture on ethical behavior of medical representatives. Medical
      representatives working for both domestic and multinational companies constitutes
      the sample (n=300). Data is collected using a simple random and cluster sampling 
      through a structured questionnaire. The research design is hypothesis testing. It
      is a cross-sectional and correlational study, conducted under non-contrived
      settings. Chi-square tests were shows that there is an association between the
      organizational culture and ethical behavior of medical representatives. In
      addition, the strength of the association is measured which report to Cramer's V 
      of 63.1% and Phi Value of 2.749. Results indicate that multinational company
      medical reps are more ethical compared to domestic company medical
      representatives vast difference in both variance and in t test results. Through
      better organizational culture, pharmaceutical companies can create the most
      desirable behavior among their employees. Authors conclude that apart from
      organizational culture, the study of additional organizational, individual and
      external factors are imperative for better understanding of ethical behavior of
      medical representatives in the pharmaceutical industry in India.
FAU - Nagashekhara, Molugulu
AU  - Nagashekhara M
AD  - Masterskill College of Nursing and Health, KK Metro Branch, Kota Kinabalu, Sabah,
      Malaysia.
FAU - Agil, Syed Omar Syed
AU  - Agil SO
AD  - Professor and Deputy Dean, Razak School of Government, Universiti Tun Abdul
      Razak, Capital Square, Block C & D No. 8, Jalan Munshi Abdullah, 50100 Kuala
      Lumpur, Malaysia.
LA  - eng
PT  - Journal Article
DEP - 20120215
PL  - India
TA  - J Basic Clin Pharm
JT  - Journal of basic and clinical pharmacy
JID - 101599515
PMC - PMC3979241
OTO - NOTNLM
OT  - Medical representatives
OT  - ethical behavior
OT  - organizational culture
EDAT- 2011/12/01 00:00
MHDA- 2011/12/01 00:01
CRDT- 2014/05/15 06:00
PHST- 2011/11/26 00:00 [received]
PHST- 2012/01/27 00:00 [accepted]
PHST- 2014/05/15 06:00 [entrez]
PHST- 2011/12/01 00:00 [pubmed]
PHST- 2011/12/01 00:01 [medline]
AID - 10.4103/0976-0105.103828 [doi]
PST - ppublish
SO  - J Basic Clin Pharm. 2011 Dec;3(1):219-23. doi: 10.4103/0976-0105.103828. Epub
      2012 Feb 15.


PMID- 23634354
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 2163-0402 (Print)
IS  - 2163-0402 (Linking)
VI  - 1
IP  - 1
DP  - 2011 Dec
TI  - Advising patients about obtaining genomic profiles.
PG  - 5-13
AB  - Neurologists, as all physicians, should begin to familiarize themselves with
      elements of genomic medicine to help their patients navigate the promises and
      pitfalls of obtaining genomic profiles. The neurologist should encourage a
      realistic assessment of the patient's expectations regarding the genetic
      information to be provided and apprise the patient of the challenges involved in 
      obtaining interpretable, clinically useful information. A review of risks of
      obtaining genomic information is equally important. Discrimination, loss of
      privacy, receiving inaccurate or unwanted information, and learning information
      that may create obligations to disclose to others are all possibilities. As
      genomic research and direct-to-consumer opportunities to obtain genomic
      information expand, reliance on personal physicians for ethical advice based on
      current advancements in genomic profiling should be anticipated.
FAU - Chen, Donna T
AU  - Chen DT
AD  - Center for Biomedical Ethics and Humanities (DTC, LLS), Department of Public
      Health Sciences (DTC, LLS), Department of Psychiatry and Neurobehavioral Sciences
      (DTC), and School of Law (LLS), Center for Biomedical Ethics and Humanities,
      University of Virginia Health System, Charlottesville.
FAU - Shepherd, Lois L
AU  - Shepherd LL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Neurol Clin Pract
JT  - Neurology. Clinical practice
JID - 101577149
PMC - PMC3613189
EDAT- 2011/12/01 00:00
MHDA- 2011/12/01 00:01
CRDT- 2013/05/02 06:00
PHST- 2013/05/02 06:00 [entrez]
PHST- 2011/12/01 00:00 [pubmed]
PHST- 2011/12/01 00:01 [medline]
AID - 10.1212/CPJ.0b013e31823cd13c [doi]
AID - CPJ200012 [pii]
PST - ppublish
SO  - Neurol Clin Pract. 2011 Dec;1(1):5-13. doi: 10.1212/CPJ.0b013e31823cd13c.


PMID- 23610515
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130424
LR  - 20211021
IS  - 0899-8299 (Print)
IS  - 0899-8299 (Linking)
VI  - 43
IP  - 3
DP  - 2011 Dec
TI  - IMANA-Hofstra Ethics Symposium: Closing Remarks.
PG  - 223-4
LID - 10.5915/43-3-9580 [doi]
FAU - Khan, Faroque Ahmed
AU  - Khan FA
AD  - Master, American College of Physicians, SUNY, Stony Brook, Stony Brook, New York.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J IMA
JT  - The Journal of IMA
JID - 8903928
PMC - PMC3516119
EDAT- 2011/12/01 00:00
MHDA- 2011/12/01 00:01
CRDT- 2013/04/24 06:00
PHST- 2013/04/24 06:00 [entrez]
PHST- 2011/12/01 00:00 [pubmed]
PHST- 2011/12/01 00:01 [medline]
AID - 10.5915/43-3-9580 [doi]
AID - jima-43-3-9580 [pii]
PST - ppublish
SO  - J IMA. 2011 Dec;43(3):223-4. doi: 10.5915/43-3-9580.


PMID- 23610514
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130424
LR  - 20211021
IS  - 0899-8299 (Print)
IS  - 0899-8299 (Linking)
VI  - 43
IP  - 3
DP  - 2011 Dec
TI  - The spectrum of neurological recovery.
PG  - 219-22
LID - 10.5915/43-3-8735 [doi]
AB  - The equivalence of brain death with death is largely, although not universally
      accepted. Patients may have suffered insults such as cardiac arrest, vascular
      catastrophe, poisoning, or head trauma. Early identification of patients at
      greatest risk of poor neurologic outcome and management in the appropriate
      critical care setting is the key to maximizing neurological recovery. Recent
      technological advances and neuroimaging have made it possible to predict
      neurological reversibility with great accuracy. Significant improvements in
      therapy such as hypothermia, will improve outcomes in neurological catastrophies,
      particularly in anoxic-ischemic encephalopathy. The clinical spectrum and
      diagnostic criteria of minimally conscious and vegetative states is reviewed. The
      current understanding of the differences in prognosis and prediction of
      meaningful cognitive and functional recovery in each neurological state is
      described. Establishing an understanding of the ethical principles that guide
      medical decisions in clinical practice related to different neurological states
      is evolving into a new field called neuroethics.
FAU - Mir, Tanveer P
AU  - Mir TP
AD  - Chief Palliative and Geriatric Medicine, Department of Palliative and Geriatric
      Medicne, Long Island Jewish Medical Center, North Shore University Hospital,
      Manhasset, New York.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J IMA
JT  - The Journal of IMA
JID - 8903928
PMC - PMC3516123
OTO - NOTNLM
OT  - Brain death
OT  - coma
OT  - functional MRI
OT  - hypothermia protocol
OT  - hypoxic-ischemic brain injury
OT  - minimally conscious state
OT  - neuron-specific enolase
OT  - persistent vegetative state
EDAT- 2011/12/01 00:00
MHDA- 2011/12/01 00:01
CRDT- 2013/04/24 06:00
PHST- 2013/04/24 06:00 [entrez]
PHST- 2011/12/01 00:00 [pubmed]
PHST- 2011/12/01 00:01 [medline]
AID - 10.5915/43-3-8735 [doi]
AID - jima-43-3-8735 [pii]
PST - ppublish
SO  - J IMA. 2011 Dec;43(3):219-22. doi: 10.5915/43-3-8735.


PMID- 23610513
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130424
LR  - 20211021
IS  - 0899-8299 (Print)
IS  - 0899-8299 (Linking)
VI  - 43
IP  - 3
DP  - 2011 Dec
TI  - Informed consent with a focus on islamic views.
PG  - 215-8
LID - 10.5915/43-3-9040 [doi]
AB  - For at least 50 years informed consent in medicine has focused on the principle
      of autonomy. Recently, attention has been given to informed consent being a
      shared decision. A primary mandate to do what is in the best interest of the
      patient still remains. The shared view looks to expand beyond the dyadic image of
      doctor and patient, to acknowledge the essential contribution to be made to
      informed consent from the cultural, religious, and personal values. This paper
      explores some of the cultural aspects of Islam that should influence informed
      consent.
FAU - Packer, Samuel
AU  - Packer S
AD  - Chair, Ethics Committee, North Shore University Hospital, Long Island Jewish
      Medical Center, Professor of Ophthalmology, Hofstra North Shore Long Island
      Jewish School of Medicine, Long Island, New York.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J IMA
JT  - The Journal of IMA
JID - 8903928
PMC - PMC3516121
OTO - NOTNLM
OT  - Informed consent
OT  - Islam
OT  - culture
OT  - ethics
OT  - humanism
OT  - professionalism
EDAT- 2011/12/01 00:00
MHDA- 2011/12/01 00:01
CRDT- 2013/04/24 06:00
PHST- 2013/04/24 06:00 [entrez]
PHST- 2011/12/01 00:00 [pubmed]
PHST- 2011/12/01 00:01 [medline]
AID - 10.5915/43-3-9040 [doi]
AID - jima-43-3-9040 [pii]
PST - ppublish
SO  - J IMA. 2011 Dec;43(3):215-8. doi: 10.5915/43-3-9040.


PMID- 23610509
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130424
LR  - 20211021
IS  - 0899-8299 (Print)
IS  - 0899-8299 (Linking)
VI  - 43
IP  - 3
DP  - 2011 Dec
TI  - Postmortem and perimortem cesarean section: historical, religious and ethical
      considerations.
PG  - 194-200
LID - 10.5915/43-3-7099 [doi]
AB  - Guillimeau was the first to use the term cesarean section (CS) in 1598, but this 
      name became universal only in the 20th century. The many theories of the origin
      of this name will be discussed. This surgery has been reported to be performed in
      all cultures dating to ancient times. In the past, it was mainly done to deliver 
      a live baby from a dead mother, hence the name postmortem CS (PMCS). Many heroes 
      are reported to have been delivered this way. Old Jewish sacred books have made
      references to abdominal delivery. It was especially encouraged and often mandated
      in Catholicism. There is evidence that the operation was done in Muslim countries
      in the middle ages. Islamic rulings support the performance of PMCS. Now that
      most maternal deaths occur in the hospital, perimortem CS (PRMCS) is recommended 
      for the delivery of a fetus after 24 weeks from a pregnant woman with cardiac
      arrest. It is believed that emergent delivery within four minutes of initiation
      of cardiopulmonary resuscitation (CPR) improves the chances of success of
      maternal resuscitation and survival and increases the chance of delivering a
      neurologically intact neonate. It is agreed that physicians are not to be held
      legally liable for the performance of PMCS and PRMCS regardless of the outcome.
      The ethical aspects of these operations are also discussed including a discussion
      about PMCS for the delivery of women who have been declared brain dead.
FAU - Fadel, Hossam E
AU  - Fadel HE
AD  - Maternal Fetal Medicine, University Hospital, Clinical Professor, Department of
      Obstetrics and Gynecology, Medical College of Georgia, Augusta, Georgia.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J IMA
JT  - The Journal of IMA
JID - 8903928
PMC - PMC3516125
OTO - NOTNLM
OT  - Catholicism
OT  - Islam
OT  - Judaism
OT  - Postmortem cesarean section
OT  - brain death
OT  - history of medicine
OT  - medical ethics
OT  - perimortem cesarean section
EDAT- 2011/12/01 00:00
MHDA- 2011/12/01 00:01
CRDT- 2013/04/24 06:00
PHST- 2013/04/24 06:00 [entrez]
PHST- 2011/12/01 00:00 [pubmed]
PHST- 2011/12/01 00:01 [medline]
AID - 10.5915/43-3-7099 [doi]
AID - jima-43-3-7099 [pii]
PST - ppublish
SO  - J IMA. 2011 Dec;43(3):194-200. doi: 10.5915/43-3-7099.


PMID- 23610507
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130424
LR  - 20211021
IS  - 0899-8299 (Print)
IS  - 0899-8299 (Linking)
VI  - 43
IP  - 3
DP  - 2011 Dec
TI  - Ethical dilemmas in decision making at limits of neonatal viability.
PG  - 188-92
LID - 10.5915/43-3-8972 [doi]
AB  - The survival rate for extremely preterm infants has improved over the last two
      decades. Although the incidence of such births is about 2%, the impact of preterm
      birth on these infants, their families, health-care providers, and society is
      profound. The birth of an extremely low birth weight (ELBW) and early gestational
      age infant poses complex medical, social, and ethical challenges to the family
      and health-care professionals. Survivors have an increased risk of chronic
      medical problems and disability. It is difficult to make decisions while trying
      to provide optimal medical care to the infant and supporting the family when
      delivery occurs at the threshold of viability because outcome at that time is
      highly unpredictable. Such decisions may have lifelong consequences for those
      involved. An individualized prognostic strategy appears to be the most
      appropriate approach. While keeping the patient's best interest as the primary
      objective, the goal is to reach, through a process of effective communication
      between the parents and physicians, a consensual decision that respects the
      parents' wishes and promotes physician beneficence.
FAU - Nadroo, Ali M
AU  - Nadroo AM
AD  - Assistant Professor of Clinical Pediatrics, Weill Medical College of Cornell
      University New York, Associate Director of Neonatal Intensive Care Unit,
      Associate Program director Pediatrics, New York Methodist Hospital, New York, New
      York.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J IMA
JT  - The Journal of IMA
JID - 8903928
PMC - PMC3516104
OTO - NOTNLM
OT  - ethics
OT  - live birth
OT  - low-birth weight
OT  - preterm birth
OT  - viability
EDAT- 2011/12/01 00:00
MHDA- 2011/12/01 00:01
CRDT- 2013/04/24 06:00
PHST- 2013/04/24 06:00 [entrez]
PHST- 2011/12/01 00:00 [pubmed]
PHST- 2011/12/01 00:01 [medline]
AID - 10.5915/43-3-8972 [doi]
AID - jima-43-3-8972 [pii]
PST - ppublish
SO  - J IMA. 2011 Dec;43(3):188-92. doi: 10.5915/43-3-8972.


PMID- 23610506
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130424
LR  - 20211021
IS  - 0899-8299 (Print)
IS  - 0899-8299 (Linking)
VI  - 43
IP  - 3
DP  - 2011 Dec
TI  - Ethical aspects of prenatal diagnosis of fetal malformations.
PG  - 182-8
LID - 10.5915/43-9560 [doi]
AB  - Fetal malformations complicate approximately 3% of all pregnancies. Many of these
      are minor or can be corrected after birth, but there are certain malformations
      that are lethal and others that are severe and others, that, even if corrected
      lead to permanent disability. Advances in prenatal diagnosis made possible the
      diagnosis of many fetal malformations. This led to the concept of the fetus a
      patient, independent of the pregnant woman, even though the moral status of the
      fetus is in dispute. Many of the lethal malformations are untreatable. However,
      for some, innovative in utero treatments, both medical and surgical, became
      possible. These interventions should be evaluated for the relative benefit and
      risk for both the fetus and the mother, because any such treatment has to involve
      the integrity of her body. This raises the ethical question of beneficence (to
      the fetus) versus the autonomy of the pregnant woman. The process of resolving
      this issue will be discussed, especially how to obtain a truly informed consent. 
      For the lethal malformations or for those severe or multiple malformations whose 
      treatment is theoretically possible but the results of such treatment are
      unpredictable or may lead to life long disabilities and serious burdens for the
      infant or child and the family, prenatal counseling should include "prenatal
      advance directive" and a plan for palliative care, the components of which will
      be described.
FAU - Fadel, Hossam E
AU  - Fadel HE
AD  - Maternal Fetal Medicine, University Hospital, Clinical Professor, Department of
      Obstetrics and Gynecology, Medical College of Georgia, Augusta, Georgia.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J IMA
JT  - The Journal of IMA
JID - 8903928
PMC - PMC3516115
OTO - NOTNLM
OT  - Fetal malformations
OT  - fetal surgery
OT  - fetal therapy
OT  - medical ethics
OT  - palliative care
OT  - prenatal counseling
OT  - prenatal diagnosis
EDAT- 2011/12/01 00:00
MHDA- 2011/12/01 00:01
CRDT- 2013/04/24 06:00
PHST- 2013/04/24 06:00 [entrez]
PHST- 2011/12/01 00:00 [pubmed]
PHST- 2011/12/01 00:01 [medline]
AID - 10.5915/43-9560 [doi]
AID - jima-43-3-9560 [pii]
PST - ppublish
SO  - J IMA. 2011 Dec;43(3):182-8. doi: 10.5915/43-9560.


PMID- 23610504
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130424
LR  - 20211021
IS  - 0899-8299 (Print)
IS  - 0899-8299 (Linking)
VI  - 43
IP  - 3
DP  - 2011 Dec
TI  - End of Life Care and the Chaplain's Role on the Medical Team.
PG  - 173-8
LID - 10.5915/43-3-8392 [doi]
AB  - This article depicts a chaplain's role in various learning and teaching
      situations, including end-of-life care and cases requiring cultural competency
      and gender preferences. The cases exemplify and underscore the difference between
      the role of a chaplain and the imam, as well as the necessity to have imams and
      both male and female chaplains in the hospital. It also describes the training,
      education, pastoral formation, pastoral identity, and roots of pastoral care in
      the Islamic tradition. The article explores the challenges of this new profession
      and advocates having a Muslim chaplain available in the hospital to serve Muslim 
      patients, families, and the non-Muslim staff.
FAU - Lahaj, Mary
AU  - Lahaj M
AD  - Clinical Pastoral Education (CPE) Certified, Chaplain, Groton School, Groton,
      Massachusetts.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J IMA
JT  - The Journal of IMA
JID - 8903928
PMC - PMC3516106
OTO - NOTNLM
OT  - Islamic ethics
OT  - chaplaincy
OT  - cultural competency
OT  - imam
OT  - pastoral care
EDAT- 2011/12/01 00:00
MHDA- 2011/12/01 00:01
CRDT- 2013/04/24 06:00
PHST- 2013/04/24 06:00 [entrez]
PHST- 2011/12/01 00:00 [pubmed]
PHST- 2011/12/01 00:01 [medline]
AID - 10.5915/43-3-8392 [doi]
AID - jima-43-3-8392 [pii]
PST - ppublish
SO  - J IMA. 2011 Dec;43(3):173-8. doi: 10.5915/43-3-8392.


PMID- 23610503
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130424
LR  - 20211021
IS  - 0899-8299 (Print)
IS  - 0899-8299 (Linking)
VI  - 43
IP  - 3
DP  - 2011 Dec
TI  - Care of the terminally ill from religious perspectives: role of palliative and
      hospice care.
PG  - 168-73
LID - 10.5915/43-3-8734 [doi]
AB  - Health care should make an attempt to understand the different religious
      principles that affect end-of-life decisions in patient care. With advanced
      illness, defining an ethical framework is essential to understanding sensitive
      issues. Compassionate care is crucial in all end-of-life care settings. Physician
      awareness is a key principle in inculcating the religious values of patients.
      Cultural and religious awareness on the part of the health-care team is needed to
      provide patients with effective end-of-life palliative and hospice care.
FAU - Mir, Tanveer
AU  - Mir T
AD  - Associate Chief, Geriatrics and Palliative Medicine, Long Island Jewish Medical
      Center, North Shore Long Island Jewish Health System, New York, New York.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J IMA
JT  - The Journal of IMA
JID - 8903928
PMC - PMC3516118
OTO - NOTNLM
OT  - End-of-life
OT  - Islam
OT  - hospice
OT  - palliative care
OT  - religion
EDAT- 2011/12/01 00:00
MHDA- 2011/12/01 00:01
CRDT- 2013/04/24 06:00
PHST- 2013/04/24 06:00 [entrez]
PHST- 2011/12/01 00:00 [pubmed]
PHST- 2011/12/01 00:01 [medline]
AID - 10.5915/43-3-8734 [doi]
AID - jima-43-3-8734 [pii]
PST - ppublish
SO  - J IMA. 2011 Dec;43(3):168-73. doi: 10.5915/43-3-8734.


PMID- 23610502
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130424
LR  - 20211021
IS  - 0899-8299 (Print)
IS  - 0899-8299 (Linking)
VI  - 43
IP  - 3
DP  - 2011 Dec
TI  - Are physicians ethically obligated to address hospice as an alternative to
      "usual" treatment of advancing end-stage disease?
PG  - 160-8
LID - 10.5915/43-3-9209 [doi]
AB  - Hospice care is ideally suited to meet the psychosocial and spiritual needs of
      dying patients, providing the opportunity to settle financial, property, and
      inheritance issues; to mend lacerations in important lifetime relationships,
      including forgiving and asking forgiveness; and to assure a degree of autonomous 
      control over the environment and the social and spiritual processes that attend
      one's death. Physicians are not only imprecise in prognosticating a patient's
      time to die, they tend to be over-optimistic in their predictions. A "no" answer 
      to the question, "Would I be surprised if this patient died in the next year?" is
      a reasonable starting-point for discussing hospice care as a potential treatment 
      plan, now or in the future. Physicians have a duty to present palliative care in 
      hospice as an alternative to the recurrent hospital interventions that are
      typical in the last six to 12 months of life tor patients who are failing and
      have declining prospects for one-year survival.
FAU - Smith, Frederick A
AU  - Smith FA
AD  - Long Island Jewish Medical Center (LIJMC), Lake Success, New York, North Shore
      University Hospital, Manhasset, New York.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J IMA
JT  - The Journal of IMA
JID - 8903928
PMC - PMC3516110
OTO - NOTNLM
OT  - Palliative care
OT  - end of life
OT  - end-stage disease
OT  - hospice
OT  - informed consent
EDAT- 2011/12/01 00:00
MHDA- 2011/12/01 00:01
CRDT- 2013/04/24 06:00
PHST- 2013/04/24 06:00 [entrez]
PHST- 2011/12/01 00:00 [pubmed]
PHST- 2011/12/01 00:01 [medline]
AID - 10.5915/43-3-9209 [doi]
AID - jima-43-3-9209 [pii]
PST - ppublish
SO  - J IMA. 2011 Dec;43(3):160-8. doi: 10.5915/43-3-9209.


PMID- 23610498
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130424
LR  - 20211021
IS  - 0899-8299 (Print)
IS  - 0899-8299 (Linking)
VI  - 43
IP  - 3
DP  - 2011 Dec
TI  - Principles of biomedical ethics.
PG  - 138-43
LID - 10.5915/43-3-8476 [doi]
AB  - In this presentation, I will discuss the principles of biomedical and Islamic
      medical ethics and an interfaith perspective on end-of-life issues. I will also
      discuss three cases to exemplify some of the conflicts in ethical
      decision-making.
FAU - Athar, Shahid
AU  - Athar S
AD  - Department of Endocrinology and Medicine, St. Vincent Hospital and Indiana
      Unversity School of Medicine, Indianapolis, Indiana.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J IMA
JT  - The Journal of IMA
JID - 8903928
PMC - PMC3516124
OTO - NOTNLM
OT  - Islamic medical ethics
OT  - end of life
OT  - inter-faith
EDAT- 2011/12/01 00:00
MHDA- 2011/12/01 00:01
CRDT- 2013/04/24 06:00
PHST- 2013/04/24 06:00 [entrez]
PHST- 2011/12/01 00:00 [pubmed]
PHST- 2011/12/01 00:01 [medline]
AID - 10.5915/43-3-8476 [doi]
AID - jima-43-3-8476 [pii]
PST - ppublish
SO  - J IMA. 2011 Dec;43(3):138-43. doi: 10.5915/43-3-8476.


PMID- 23610495
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130424
LR  - 20211021
IS  - 0899-8299 (Print)
IS  - 0899-8299 (Linking)
VI  - 43
IP  - 3
DP  - 2011 Dec
TI  - Foreward to IMANA/Hofstra University Ethics Conference, 2010: End-of-Life Issues:
      Ethical and Religious Perspectives.
PG  - 111-2
LID - 10.5915/43-3-9666 [doi]
FAU - Fadel, Hossam E
AU  - Fadel HE
AD  - Maternal Fetal Medicine, University Hospital, Clinical Professor, Department of
      Obstetrics and Gynecology, Medical College of Georgia, Augusta, Georgia.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J IMA
JT  - The Journal of IMA
JID - 8903928
PMC - PMC3516105
EDAT- 2011/12/01 00:00
MHDA- 2011/12/01 00:01
CRDT- 2013/04/24 06:00
PHST- 2013/04/24 06:00 [entrez]
PHST- 2011/12/01 00:00 [pubmed]
PHST- 2011/12/01 00:01 [medline]
AID - 10.5915/43-3-9666 [doi]
AID - jima-43-3-9666 [pii]
PST - ppublish
SO  - J IMA. 2011 Dec;43(3):111-2. doi: 10.5915/43-3-9666.


PMID- 22569675
OWN - NLM
STAT- MEDLINE
DCOM- 20160423
LR  - 20190911
IS  - 0080-6234 (Print)
IS  - 0080-6234 (Linking)
VI  - 45 Spec No 2
DP  - 2011 Dec
TI  - Ethics and values in health care practice: philosophical, educational, and
      political considerations.
PG  - 1797-802
LID - S0080-62342011000800028 [pii]
AB  - UNLABELLED: This paper presents philosophical, pedagogical and political
      considerations on Ethics and Values in Professional Health Care Practice. The
      current changes and crises in the world, intensified by economic turmoil, have
      affected social justice issues affecting health and education. OBJECTIVES: to
      clarify nurses' role in the context of the art to take care of clients both as
      individuals and community; to urge nurses for attention to laws and codes/norms
      as established in the profession; and to suggest the application of basic laws of
      the Philosophy of Art to nursing care. The study presents critical analysis on
      ethics and values involved in nursing actions and may affect the art of
      learning-to-be and becoming an expert professional in nursing care. The author's 
      epistemological position is presented to build competencies in the nursing as a
      health science.
FAU - Carvalho, Vilma de
AU  - Carvalho Vd
AD  - Escola de Enfermagem Anna Nery, Universidade Federal do Rio de Janeiro, Rio de
      Janeiro, RJ, Brasil, decarvalho.vilma@gmail.com.
LA  - eng
LA  - por
PT  - Journal Article
TT  - Etica e valores na pratica profissional em saude: consideracoes filosoficas,
      pedagogicas e politicas.
PL  - Brazil
TA  - Rev Esc Enferm USP
JT  - Revista da Escola de Enfermagem da U S P
JID - 0242726
MH  - *Ethics, Nursing
MH  - Humans
MH  - Nurse's Role
MH  - *Nurses
MH  - Professional Practice
EDAT- 2011/12/01 00:00
MHDA- 2016/04/24 06:00
CRDT- 2012/05/10 06:00
PHST- 2011/10/14 00:00 [received]
PHST- 2011/11/16 00:00 [accepted]
PHST- 2012/05/10 06:00 [entrez]
PHST- 2011/12/01 00:00 [pubmed]
PHST- 2016/04/24 06:00 [medline]
AID - S0080-62342011000800028 [pii]
AID - 10.1590/s0080-62342011000800028 [doi]
PST - ppublish
SO  - Rev Esc Enferm USP. 2011 Dec;45 Spec No 2:1797-802. doi:
      10.1590/s0080-62342011000800028.


PMID- 22125399
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1177-5483 (Electronic)
IS  - 1177-5467 (Linking)
VI  - 5
DP  - 2011
TI  - Intravitreal gas injection for the treatment of diabetic macular edema.
PG  - 1543-8
LID - 10.2147/OPTH.S25348 [doi]
AB  - PURPOSE: This study investigates the efficacy of an intravitreal gas injection in
      inducing a posterior vitreous detachment (PVD) in patients with clinically
      significant diabetic macular edema refractory to laser therapy. METHODS: A local 
      ethics committee-approved technique of an intravitreal injection of pure
      perfluoropropane gas (C(3)F(8)) was performed for all participants. After a
      period of prone positioning, the patients underwent regular and detailed clinical
      review. MAIN OUTCOME MEASURES: The induction of a PVD, change in macular
      thickness, change in visual acuity. RESULTS: A PVD was induced in all five eyes
      with subsequent signs of reduction in macular thickness and resolution of
      exudates. Mean visual improvement was 11 ETDRS (Early Treatment Diabetic
      Retinopathy Study) letters (range 4-21). Apart from a transient vitreous
      hemorrhage in one eye, there were no significant treatment-related complications.
      CONCLUSION: The induction of a PVD by pneumatic retinopexy appears to have a
      significant influence on diabetic macular edema in eyes which have not
      successfully responded to macular laser therapy. A randomized clinical trial is
      justified on the basis of the initial promising data.
FAU - McHugh, Dominic
AU  - McHugh D
AD  - King's College Hospital, Denmark Hill, London, England, UK.
FAU - Gupta, Bhaskar
AU  - Gupta B
FAU - Saeed, Manzar
AU  - Saeed M
LA  - eng
PT  - Case Reports
DEP - 20111026
PL  - New Zealand
TA  - Clin Ophthalmol
JT  - Clinical ophthalmology (Auckland, N.Z.)
JID - 101321512
PMC - PMC3218162
OTO - NOTNLM
OT  - OCT
OT  - optical coherence tomography
OT  - perfluoropropane
OT  - posterior vitreous detachment
EDAT- 2011/11/30 06:00
MHDA- 2011/11/30 06:01
CRDT- 2011/11/30 06:00
PHST- 2011/11/30 06:00 [entrez]
PHST- 2011/11/30 06:00 [pubmed]
PHST- 2011/11/30 06:01 [medline]
AID - 10.2147/OPTH.S25348 [doi]
AID - opth-5-1543 [pii]
PST - ppublish
SO  - Clin Ophthalmol. 2011;5:1543-8. doi: 10.2147/OPTH.S25348. Epub 2011 Oct 26.


PMID- 22124918
OWN - NLM
STAT- MEDLINE
DCOM- 20120403
LR  - 20111129
IS  - 1678-4561 (Electronic)
IS  - 1413-8123 (Linking)
VI  - 16
IP  - 12
DP  - 2011 Dec
TI  - [The reprocessing of medical products: from regulatory polices to operational
      practices].
PG  - 4787-94
LID - S1413-81232011001300027 [pii]
AB  - The number of technological resources used in health care interventions is
      growing and continually expanding with the introduction of new products and
      articles. Problems associated with the reutilization of medical products, both
      reusable and of single use, affect policies and related technical-operational,
      economic, political, ethical, legal, and environmental matters. This study aims
      to contextualize the regulatory systems of medical products, and analyze the
      subsequent operational implications for Brazilian hospital practices. The article
      consists of a bibliographic review, carried out without time and language
      restriction, utilizing the Web of Science, Bireme, Scielo and Lilacs databases,
      with the support of specific descriptors. This study uses the contextualization
      of regulatory plans for medical products across the world and in Brazil and the
      existing condition of standardization of the reprocessing of these products as
      the assessment sources with which to analyze the operational implications for
      these practices in Brazilian hospitals.
FAU - Costa, Eliana Auxiliadora Magalhaes
AU  - Costa EA
AD  - Instituto de Saude Coletiva, Universidade Federal da Bahia, Salvador, BA.
      costaeliana2003@hotmail.com
FAU - Costa, Edina Alves
AU  - Costa EA
LA  - por
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Reprocessamento de produtos medicos: da politica regulatoria a pratica
      operacional.
PL  - Brazil
TA  - Cien Saude Colet
JT  - Ciencia & saude coletiva
JID - 9713483
SB  - IM
MH  - Brazil
MH  - Equipment Reuse/*standards
MH  - Health Policy
MH  - Humans
MH  - Internationality
EDAT- 2011/11/30 06:00
MHDA- 2012/04/04 06:00
CRDT- 2011/11/30 06:00
PHST- 2009/09/22 00:00 [received]
PHST- 2010/01/27 00:00 [accepted]
PHST- 2011/11/30 06:00 [entrez]
PHST- 2011/11/30 06:00 [pubmed]
PHST- 2012/04/04 06:00 [medline]
AID - S1413-81232011001300027 [pii]
PST - ppublish
SO  - Cien Saude Colet. 2011 Dec;16(12):4787-94.


PMID- 22124909
OWN - NLM
STAT- MEDLINE
DCOM- 20120403
LR  - 20190907
IS  - 1678-4561 (Electronic)
IS  - 1413-8123 (Linking)
VI  - 16
IP  - 12
DP  - 2011 Dec
TI  - [Working in mental health services in the context of Brazilian psychiatric
      reform: a technical, political and ethical challenge].
PG  - 4685-94
LID - S1413-81232011001300017 [pii]
AB  - This paper deals with mental health taken within the context of Brazilian
      Psychiatric Reform and profiling the transformations in the organization of work 
      processes. This has occurred as a result of the advances with respect to the
      implementation of the services that replaced the classic psychiatric model and
      the reconfiguration of the scope of intervention and practices. From this
      standpoint, the paper seeks to pinpoint the contradictions and problems related
      to this process and its impact on the organization of work processes on the
      management of services and on worker health. Lastly, strategies are prepared for 
      the purpose of tackling the problem, chief among which are the following: the
      redefinition of spaces, practices, and the relationships among the different
      actors, namely managers, workers, and users; the adoption of co-management
      mechanisms; and clinical-institutional supervision.
FAU - Sampaio, Jose Jackson Coelho
AU  - Sampaio JJ
AD  - Grupo de Pesquisa Vida e Trabalho, Centro de Ciencias da Saude, Universidade
      Estadual do Ceara, Fortaleza, CE. sampaiojackson@gmail.com
FAU - Guimaraes, Jose Maria Ximenes
AU  - Guimaraes JM
FAU - Carneiro, Cleide
AU  - Carneiro C
FAU - Garcia Filho, Carlos
AU  - Garcia Filho C
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - O trabalho em servicos de saude mental no contexto da reforma psiquiatrica: um
      desafio tecnico, politico e etico.
PL  - Brazil
TA  - Cien Saude Colet
JT  - Ciencia & saude coletiva
JID - 9713483
SB  - IM
MH  - Brazil
MH  - *Health Care Reform
MH  - Health Personnel
MH  - Humans
MH  - Mental Health Services/ethics/*organization & administration/standards
MH  - Politics
EDAT- 2011/11/30 06:00
MHDA- 2012/04/04 06:00
CRDT- 2011/11/30 06:00
PHST- 2011/09/08 00:00 [received]
PHST- 2011/09/30 00:00 [accepted]
PHST- 2011/11/30 06:00 [entrez]
PHST- 2011/11/30 06:00 [pubmed]
PHST- 2012/04/04 06:00 [medline]
AID - S1413-81232011001300017 [pii]
AID - 10.1590/s1413-81232011001300017 [doi]
PST - ppublish
SO  - Cien Saude Colet. 2011 Dec;16(12):4685-94. doi: 10.1590/s1413-81232011001300017.


PMID- 22124908
OWN - NLM
STAT- MEDLINE
DCOM- 20120403
LR  - 20190907
IS  - 1678-4561 (Electronic)
IS  - 1413-8123 (Linking)
VI  - 16
IP  - 12
DP  - 2011 Dec
TI  - [The role of psychiatry in the Brazilian psychiatric reform].
PG  - 4675-84
LID - S1413-81232011001300016 [pii]
AB  - Psychiatry emerged just over two hundred years ago as a special branch of
      medicine offering institutional care for the insane, since it encompassed the
      fields of medicine, natural history (biology) and philosophy (humanities). It
      appeared at a time marked by the transition with the exclusion apparatus of the
      marginalized people of the Old Regime and by epistemic pluralism. In this
      article, the contribution that psychiatry can make today - just over two
      centuries and some important conceptual and institutional rearrangements later - 
      is discussed. It is well established in the academic world and socially
      legitimized, albeit at another moment of transition, in which new paradigms of
      care are established placing importance on the contextual and intersubjective
      situation of psychic distress. Redefining Pinelian intuition using contemporary
      vocabulary regarding the epistemological and ethical challenge of an area of
      knowledge and practice of care the scope of which is psychic distress, the thesis
      will be proposed that it is also necessary to articulate the planes of body,
      experience and narrative in an ongoing dialogue.
FAU - Serpa Junior, Octavio Domont de
AU  - Serpa Junior OD
AD  - Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro.
      domserpa@gmail.com
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - O papel da psiquiatria na reforma psiquiatrica.
PL  - Brazil
TA  - Cien Saude Colet
JT  - Ciencia & saude coletiva
JID - 9713483
SB  - IM
MH  - Brazil
MH  - *Health Care Reform
MH  - Humans
MH  - Mental Health Services/*standards
MH  - *Psychiatry
EDAT- 2011/11/30 06:00
MHDA- 2012/04/04 06:00
CRDT- 2011/11/30 06:00
PHST- 2011/09/08 00:00 [received]
PHST- 2011/09/30 00:00 [accepted]
PHST- 2011/11/30 06:00 [entrez]
PHST- 2011/11/30 06:00 [pubmed]
PHST- 2012/04/04 06:00 [medline]
AID - S1413-81232011001300016 [pii]
AID - 10.1590/s1413-81232011001300016 [doi]
PST - ppublish
SO  - Cien Saude Colet. 2011 Dec;16(12):4675-84. doi: 10.1590/s1413-81232011001300016.


PMID- 22124829
OWN - NLM
STAT- MEDLINE
DCOM- 20120403
LR  - 20190907
IS  - 1678-4561 (Electronic)
IS  - 1413-8123 (Linking)
VI  - 16
IP  - 11
DP  - 2011 Nov
TI  - [The ethical dimension of professional training in health: a case study in
      undergraduate dentistry courses].
PG  - 4481-92
LID - S1413-81232011001200021 [pii]
AB  - This case study sought to delineate an overview of ethics training on Brazilian
      undergraduate dentistry courses, in order to gather knowledge related to the
      changes required with regard to training ethically competent health
      professionals. Thus, the scope of this study ethics training of students was
      defined by a conceptual reference, constructed at the interface of inter-related 
      concepts. The reference also contributed to the outlining of this qualitative
      research, which includes a questionnaire with ethical-pedagogical questions, sent
      to the coordinators of 15 courses selected for the sample. The results indicated 
      a timely commitment of the courses to the ethical dimension of professional
      training, as well as advances in training of teaching staff, the profile of the
      graduate and the curricular integration process. On the other hand, they
      highlighted deficiencies regarding the contents concerned with the cultural,
      humanistic and political background in relation to didactic orientation, the
      teaching-learning scenarios, the evaluation process, and also the incipient
      presence of bioethics regarding the subject and the crossover curricular theme,
      together with the lack of specific training of the teaching staff.
FAU - Finkler, Mirelle
AU  - Finkler M
AD  - Universidade Federal de Santa Catarina, Florianopolis, Brazil.
      mirellefinkler@yahoo.com.br
FAU - Caetano, Joao Carlos
AU  - Caetano JC
FAU - Ramos, Flavia Regina Souza
AU  - Ramos FR
LA  - por
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
TT  - A dimensao etica da formacao profissional em saude: estudo de caso com cursos de 
      graduacao em odontologia.
PL  - Brazil
TA  - Cien Saude Colet
JT  - Ciencia & saude coletiva
JID - 9713483
SB  - IM
MH  - Brazil
MH  - *Education, Dental
MH  - *Ethics, Dental
EDAT- 2011/11/30 06:00
MHDA- 2012/04/04 06:00
CRDT- 2011/11/30 06:00
PHST- 2009/08/21 00:00 [received]
PHST- 2009/10/05 00:00 [accepted]
PHST- 2011/11/30 06:00 [entrez]
PHST- 2011/11/30 06:00 [pubmed]
PHST- 2012/04/04 06:00 [medline]
AID - S1413-81232011001200021 [pii]
AID - 10.1590/s1413-81232011001200021 [doi]
PST - ppublish
SO  - Cien Saude Colet. 2011 Nov;16(11):4481-92. doi: 10.1590/s1413-81232011001200021.


PMID- 22124649
OWN - NLM
STAT- MEDLINE
DCOM- 20120403
LR  - 20191112
IS  - 1809-4546 (Electronic)
IS  - 0100-6991 (Linking)
VI  - 38
IP  - 5
DP  - 2011 Sep-Oct
TI  - [Medical ethics under the bioethics' point of view: the moral surgical practice].
PG  - 355-60
LID - S0100-69912011000500013 [pii]
AB  - The professional practice of medicine today has a strong biological approach due 
      to the increasing specialization of medical science. Often, science itself does
      not help to address and resolve a particular situation of a medical professional,
      and this is where human and social sciences, and especially other disciplines
      such as bioethics, can give a more humane and socialist approach, by
      systematically studying human behavior in the field of life and health sciences, 
      considering moral values and principles. As part of this study, the segment that 
      is limited to the analysis of ethical conflicts arising from the practice of
      medicine and patient care is known as medical ethics. Medical ethics, in the
      context of surgery, involves the integration of the surgical patient with the
      nature of the surgeon, influenced by his training and experience, his sensitivity
      to identify what is right. Ethics should not only be in the procedure, the
      surgery itself or in what happens in an operating room or even in the exercise of
      surgery as a specialty. Ethics must be in the life and conduct of the surgeon, so
      that all life and professional acts should be ethically valid.
FAU - Antonio, Eliana Maria Restum
AU  - Antonio EM
AD  - Chefe da 17 Enfermaria do Hospital Geral da Santa Casa da Misericordia do Rio de 
      Janeiro- - RJ-BR. elianarestum@yahoo.com.br
FAU - Fontes, Tereza Maria Pereira
AU  - Fontes TM
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - A etica medica sob o vies da bioetica: o exercicio moral da cirurgia.
PL  - Brazil
TA  - Rev Col Bras Cir
JT  - Revista do Colegio Brasileiro de Cirurgioes
JID - 7809515
SB  - IM
MH  - *Bioethics
MH  - Ethics, Medical
MH  - General Surgery/*ethics
MH  - Humans
EDAT- 2011/11/30 06:00
MHDA- 2012/04/04 06:00
CRDT- 2011/11/30 06:00
PHST- 2011/05/15 00:00 [received]
PHST- 2011/07/28 00:00 [accepted]
PHST- 2011/11/30 06:00 [entrez]
PHST- 2011/11/30 06:00 [pubmed]
PHST- 2012/04/04 06:00 [medline]
AID - S0100-69912011000500013 [pii]
AID - 10.1590/s0100-69912011000500013 [doi]
PST - ppublish
SO  - Rev Col Bras Cir. 2011 Sep-Oct;38(5):355-60. doi:
      10.1590/s0100-69912011000500013.


PMID- 22124472
OWN - NLM
STAT- MEDLINE
DCOM- 20120325
LR  - 20151119
IS  - 1539-073X (Electronic)
IS  - 1520-9229 (Linking)
VI  - 13
IP  - 4
DP  - 2011 Oct-Dec
TI  - Ethical climates in for-profit, nonprofit, and government skilled nursing
      facilities: managerial implications for partnerships.
PG  - 125-31; quiz 132-3
LID - 10.1097/NHL.0b013e31823b6835 [doi]
AB  - This study investigates ethical climates in government, nonprofit, and for-profit
      nursing homes and determines their similarities and differences. Surveys were
      collected from 656 (21.4%) licensed nurses who worked in 100 skilled nursing
      facilities in one Midwestern state. Shared law and code and caring ethical
      climates were identified across the 3 sector nursing homes. Those climates were
      also polarized. Important implications were drawn for consideration of ethical
      perceptions of each sector during negotiations and contract management.
FAU - Filipova, Anna A
AU  - Filipova AA
AD  - Department of Public Administration, University of Wisconsin Oshkosh, USA.
      filipova@uwosh.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - JONAS Healthc Law Ethics Regul
JT  - JONA'S healthcare law, ethics and regulation
JID - 100888423
MH  - Adult
MH  - *Ethics, Institutional
MH  - Female
MH  - Government
MH  - Humans
MH  - Middle Aged
MH  - Nurses/psychology
MH  - Organizational Culture
MH  - Organizations, Nonprofit/ethics/organization & administration
MH  - Ownership/*ethics
MH  - Skilled Nursing Facilities/*ethics/organization & administration
MH  - Surveys and Questionnaires
EDAT- 2011/11/30 06:00
MHDA- 2012/03/27 06:00
CRDT- 2011/11/30 06:00
PHST- 2011/11/30 06:00 [entrez]
PHST- 2011/11/30 06:00 [pubmed]
PHST- 2012/03/27 06:00 [medline]
AID - 10.1097/NHL.0b013e31823b6835 [doi]
AID - 00128488-201110000-00004 [pii]
PST - ppublish
SO  - JONAS Healthc Law Ethics Regul. 2011 Oct-Dec;13(4):125-31; quiz 132-3. doi:
      10.1097/NHL.0b013e31823b6835.


PMID- 22124471
OWN - NLM
STAT- MEDLINE
DCOM- 20120325
LR  - 20121109
IS  - 1539-073X (Electronic)
IS  - 1520-9229 (Linking)
VI  - 13
IP  - 4
DP  - 2011 Oct-Dec
TI  - Is it ethical for a medical practice to dismiss a family based on their decision 
      not to have their child immunized?
PG  - 122-4
LID - 10.1097/NHL.0b013e31823a61e5 [doi]
AB  - The parents' decision not to have their child immunized stirs up much controversy
      in the public sector and in the healthcare arena. Much debate surrounds not just 
      the parents' choice but also the practitioner's decision to refuse care based on 
      their refusal. This article presents a common and increasing scenario faced in
      pediatric practices and explores the ethical implications that it poses for the
      healthcare provider.
FAU - Nulty, Dorothy
AU  - Nulty D
AD  - College of Nursing, University of South Florida, Tampa, USA.
      dnulty@health.usf.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - JONAS Healthc Law Ethics Regul
JT  - JONA'S healthcare law, ethics and regulation
JID - 100888423
RN  - 0 (Vaccines)
MH  - *Bioethical Issues
MH  - Child
MH  - Humans
MH  - Immunization/*ethics
MH  - Infant
MH  - Parents/*psychology
MH  - *Pediatrics
MH  - Personal Autonomy
MH  - Treatment Refusal/*ethics
MH  - Vaccines/adverse effects
EDAT- 2011/11/30 06:00
MHDA- 2012/03/27 06:00
CRDT- 2011/11/30 06:00
PHST- 2011/11/30 06:00 [entrez]
PHST- 2011/11/30 06:00 [pubmed]
PHST- 2012/03/27 06:00 [medline]
AID - 10.1097/NHL.0b013e31823a61e5 [doi]
AID - 00128488-201110000-00003 [pii]
PST - ppublish
SO  - JONAS Healthc Law Ethics Regul. 2011 Oct-Dec;13(4):122-4. doi:
      10.1097/NHL.0b013e31823a61e5.


PMID- 22124304
OWN - NLM
STAT- MEDLINE
DCOM- 20120404
LR  - 20111129
IS  - 1538-8670 (Electronic)
IS  - 0744-6314 (Linking)
VI  - 42
IP  - 12
DP  - 2011 Dec
TI  - The nurse administrator on the ethics committee: a collaborative approach.
PG  - 52-4
LID - 10.1097/01.NUMA.0000406574.81214.9e [doi]
FAU - Bailey, Marcia L
AU  - Bailey ML
AD  - MetroHealth System, Cleveland, Ohio, USA.
FAU - Aulisio, Mark P
AU  - Aulisio MP
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Nurs Manage
JT  - Nursing management
JID - 8219243
MH  - *Cooperative Behavior
MH  - Ethics Committees/*organization & administration
MH  - Ethics, Nursing
MH  - Humans
MH  - *Nurse Administrators
MH  - Nursing Administration Research
EDAT- 2011/11/30 06:00
MHDA- 2012/04/05 06:00
CRDT- 2011/11/30 06:00
PHST- 2011/11/30 06:00 [entrez]
PHST- 2011/11/30 06:00 [pubmed]
PHST- 2012/04/05 06:00 [medline]
AID - 10.1097/01.NUMA.0000406574.81214.9e [doi]
AID - 00006247-201112000-00016 [pii]
PST - ppublish
SO  - Nurs Manage. 2011 Dec;42(12):52-4. doi: 10.1097/01.NUMA.0000406574.81214.9e.


PMID- 22124005
OWN - NLM
STAT- MEDLINE
DCOM- 20120411
LR  - 20191210
IS  - 1550-9613 (Electronic)
IS  - 0278-4297 (Linking)
VI  - 30
IP  - 12
DP  - 2011 Dec
TI  - Color-coded duplex sonography compared to multidetector computed tomography for
      the diagnosis of crohn disease relapse and complications.
PG  - 1691-9
AB  - OBJECTIVES: The purpose of this study was to evaluate the accuracy of color-coded
      duplex sonography for the diagnosis of Crohn disease relapse and complications
      compared to multidetector computed tomography (CT). METHODS: The Institutional
      Ethics Committee approved the protocol research, and written consent forms were
      obtained. Patients with a diagnosis of Crohn disease presenting with symptoms of 
      relapse or complications (54 patients; 27 female; ages 9-80 years; mean, 34.6
      years) were enrolled. Patients underwent color-coded duplex sonography and
      multidetector CT examinations within 2 weeks of each other. Multidetector CT was 
      the reference standard. The location and extent of diseased bowel, wall
      thickness, stenosis, hyperemia, mesenteric fat thickening, lymphadenopathy,
      abscesses, fistulas, peritoneal fluid, and signs of hepatobiliary disease were
      searched for. RESULTS: About of 80% of the patients had terminal ileal
      involvement, and 55% had disease confined to the ileum. A significant correlation
      between the two modalities was found regarding wall thickness, abscesses, and
      fistulas (P < .05). Color-coded duplex sonography had sensitivity and specificity
      of 88% and 53%, respectively, for diagnosis of luminal stenosis. Hyperemia was
      more commonly diagnosed on color-coded duplex sonography. Color-coded duplex
      sonography had sensitivity and specificity of 84% and 83% for diagnosis of
      mesenteric fat thickening and lymphadenopathy and 66% and 86% for peritoneal
      fluid. Fatty liver was found in 18% and gallstone disease in 6%. CONCLUSIONS:
      Color-coded duplex sonography was accurate in diagnosing the disease location,
      wall thickness, and extraintestinal inflammatory findings associated with Crohn
      disease, potentially placing it as the first-line imaging modality for the
      diagnosis of Crohn disease relapse and complications.
FAU - Gaitini, Diana
AU  - Gaitini D
AD  - Department of Medical Imaging, Rambam Health Care Campus and Faculty of Medicine,
      Technion, Israel Institute of Technology, Ha'alya Ha'shnia 8, PO Box 9602, 31096 
      Haifa, Israel. d_gaitini@rambam.health.gov.il
FAU - Kreitenberg, Adam J
AU  - Kreitenberg AJ
FAU - Fischer, Doron
AU  - Fischer D
FAU - Maza, Itay
AU  - Maza I
FAU - Chowers, Yehuda
AU  - Chowers Y
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PL  - England
TA  - J Ultrasound Med
JT  - Journal of ultrasound in medicine : official journal of the American Institute of
      Ultrasound in Medicine
JID - 8211547
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - Crohn Disease/*complications/*diagnostic imaging
MH  - Echocardiography, Doppler, Color/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Recurrence
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Tomography, X-Ray Computed/*methods
MH  - Young Adult
EDAT- 2011/11/30 06:00
MHDA- 2012/04/12 06:00
CRDT- 2011/11/30 06:00
PHST- 2011/11/30 06:00 [entrez]
PHST- 2011/11/30 06:00 [pubmed]
PHST- 2012/04/12 06:00 [medline]
AID - 30/12/1691 [pii]
AID - 10.7863/jum.2011.30.12.1691 [doi]
PST - ppublish
SO  - J Ultrasound Med. 2011 Dec;30(12):1691-9. doi: 10.7863/jum.2011.30.12.1691.


PMID- 22123805
OWN - NLM
STAT- MEDLINE
DCOM- 20120123
LR  - 20181201
IS  - 1538-3679 (Electronic)
IS  - 0003-9926 (Linking)
VI  - 171
IP  - 21
DP  - 2011 Nov 28
TI  - Clinical trials in the critically ill: practical and ethical challenges: comment 
      on "Efficacy of corticosteroid therapy in patients with an acute exacerbation of 
      chronic obstructive pulmonary disease receiving ventilatory support".
PG  - 1946-7
LID - 10.1001/archinternmed.2011.531 [doi]
FAU - Shorr, Andrew F
AU  - Shorr AF
AD  - Pulmonary and Critical Care Medicine, Washington Hospital Center, Washington, DC 
      20010, USA. Andrew.shorr@gmail.com
FAU - Chan, Chee M
AU  - Chan CM
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Arch Intern Med
JT  - Archives of internal medicine
JID - 0372440
RN  - 0 (Anti-Inflammatory Agents)
RN  - X4W7ZR7023 (Methylprednisolone)
SB  - IM
CON - Arch Intern Med. 2011 Nov 28;171(21):1939-46. PMID: 22123804
MH  - Anti-Inflammatory Agents/*adverse effects
MH  - Female
MH  - Humans
MH  - Male
MH  - Methylprednisolone/*adverse effects
MH  - Pulmonary Disease, Chronic Obstructive/*drug therapy
MH  - *Respiration, Artificial
EDAT- 2011/11/30 06:00
MHDA- 2012/01/24 06:00
CRDT- 2011/11/30 06:00
PHST- 2011/11/30 06:00 [entrez]
PHST- 2011/11/30 06:00 [pubmed]
PHST- 2012/01/24 06:00 [medline]
AID - 171/21/1946 [pii]
AID - 10.1001/archinternmed.2011.531 [doi]
PST - ppublish
SO  - Arch Intern Med. 2011 Nov 28;171(21):1946-7. doi: 10.1001/archinternmed.2011.531.


PMID- 22123676
OWN - NLM
STAT- MEDLINE
DCOM- 20120503
LR  - 20181201
IS  - 1744-6309 (Electronic)
IS  - 1744-6295 (Linking)
VI  - 15
IP  - 3
DP  - 2011 Sep
TI  - The role of staff in health promotion in community residences for people with
      intellectual disabilities: variation in views among managers and caregivers.
PG  - 167-76
LID - 10.1177/1744629511424833 [doi]
AB  - Managers and caregivers in community residences for people with intellectual
      disabilities are expected both to promote residents' health and to support their 
      autonomy. The aim of this article was to explore variation in views among
      managers and caregivers on the role of staff in health promotion. A qualitative
      study was conducted using semi-structured interviews with six managers and six
      caregivers. The analysis used a phenomenographic approach to categorize variation
      in views. We identified five qualitatively different main categories of roles
      staff play in health promotion: the parent, the manipulator, the coach, the
      educator and the libertarian. In addition lifestyle-related risk factors for
      ill-health and barriers to a healthy lifestyle were analysed and described using 
      qualitative content analysis. The results highlight the ethical conflict that
      faces staff trying to support a healthy lifestyle as well as the autonomy of the 
      residents.
FAU - Bergstrom, Helena
AU  - Bergstrom H
AD  - Karolinska Institutet, Stockholm, Sweden. helena.bergstrom@ki.se
FAU - Wihlman, Ulla
AU  - Wihlman U
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Intellect Disabil
JT  - Journal of intellectual disabilities : JOID
JID - 101229024
SB  - IM
MH  - Adult
MH  - Caregivers/*psychology
MH  - Female
MH  - Group Homes/*methods
MH  - Health Personnel/*psychology
MH  - *Health Promotion
MH  - Humans
MH  - Intellectual Disability/epidemiology/*nursing
MH  - *Learning
MH  - Male
MH  - Middle Aged
MH  - Qualitative Research
MH  - Risk Factors
MH  - Sweden/epidemiology
MH  - Workforce
EDAT- 2011/11/30 06:00
MHDA- 2012/05/04 06:00
CRDT- 2011/11/30 06:00
PHST- 2011/11/30 06:00 [entrez]
PHST- 2011/11/30 06:00 [pubmed]
PHST- 2012/05/04 06:00 [medline]
AID - 15/3/167 [pii]
AID - 10.1177/1744629511424833 [doi]
PST - ppublish
SO  - J Intellect Disabil. 2011 Sep;15(3):167-76. doi: 10.1177/1744629511424833.


PMID- 22123511
OWN - NLM
STAT- MEDLINE
DCOM- 20120327
LR  - 20120910
IS  - 1423-033X (Electronic)
IS  - 0254-4962 (Linking)
VI  - 45
IP  - 1
DP  - 2012
TI  - Body integrity identity disorder: the persistent desire to acquire a physical
      disability.
PG  - 3-14
LID - 10.1159/000330503 [doi]
AB  - BACKGROUND: Body integrity identity disorder (BIID) is a rare and unusual
      psychiatric condition characterized by a persistent desire to acquire a physical 
      disability (e.g., amputation, paraplegia) since childhood that to date has not
      been formally described in the psychiatric nosology. Most BIID sufferers
      experience a chronic and dysphoric sense of inappropriateness regarding their
      being able-bodied, and many have been driven to actualize their desired
      disability through surreptitious surgical or other more dangerous methods. This
      review aims to characterize the history and phenomenology of this condition, to
      present its differential diagnosis, and to consider possible etiologies,
      treatment options, and ethical considerations. SAMPLING AND METHOD: Review of the
      psychiatric and neurological literature. RESULTS: A growing body of data suggests
      the existence of a discrete entity with onset by early adolescence and a negative
      impact on functioning. Parallel neurological conditions and preliminary
      experimental investigations suggest a possible neurobiological component in at
      least a portion of cases. While attempts at treatment have been described, no
      systematic evidence for efficacy has emerged. DISCUSSION: BIID is a unique
      nosological entity with significant consequences for its sufferers and as such
      may warrant inclusion in some form in the forthcoming DSM-5 and ICD-11.
CI  - Copyright (c) 2011 S. Karger AG, Basel.
FAU - First, Michael B
AU  - First MB
AD  - Department of Psychiatry, New York State Psychiatric Institute, Columbia
      University, New York, NY 10032, USA. mbf2@columbia.edu
FAU - Fisher, Carl E
AU  - Fisher CE
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111128
PL  - Switzerland
TA  - Psychopathology
JT  - Psychopathology
JID - 8401537
SB  - IM
MH  - Amputation/*psychology
MH  - Body Dysmorphic Disorders/*classification/*diagnosis/therapy
MH  - Body Image
MH  - Disabled Persons/*psychology
MH  - Extremities
MH  - Humans
EDAT- 2011/11/30 06:00
MHDA- 2012/03/28 06:00
CRDT- 2011/11/30 06:00
PHST- 2011/03/28 00:00 [received]
PHST- 2011/07/01 00:00 [accepted]
PHST- 2011/11/30 06:00 [entrez]
PHST- 2011/11/30 06:00 [pubmed]
PHST- 2012/03/28 06:00 [medline]
AID - 000330503 [pii]
AID - 10.1159/000330503 [doi]
PST - ppublish
SO  - Psychopathology. 2012;45(1):3-14. doi: 10.1159/000330503. Epub 2011 Nov 28.


PMID- 22123471
OWN - NLM
STAT- MEDLINE
DCOM- 20120501
LR  - 20191210
IS  - 1536-0911 (Electronic)
IS  - 1536-0903 (Linking)
VI  - 11
IP  - 6
DP  - 2011 Dec
TI  - The Perinatal Palliative Care Perceptions and Barriers Scale Instrument(c):
      development and validation.
PG  - 397-403
LID - 10.1097/ANC.0b013e318233809a [doi]
AB  - PURPOSE: To devise and test an instrument measuring clinician perceptions of
      perinatal palliative care (PPC) and barriers to care delivery. THEORY: PPC was
      theorized to involve the care of pregnant women and their families after prenatal
      testing resulted in a life-limiting fetal diagnosis. Both giving birth to a child
      with a life-limiting condition or termination of pregnancy for fetal anomaly can 
      be emotionally traumatic life events. Clinicians were thought to face ethical
      dilemmas that involved approaches to care for this population. The ethical
      dilemmas were measured on a perceptions scale using items about informed consent,
      justice, beneficence, and autonomy. Barriers were theorized as obstacles to
      delivering quality PPC and included insufficient education, personal discomfort, 
      and difficulty garnering team or administrative support for care. SUBJECTS:
      Licensed clinicians practicing in the perinatal field. DESIGN: Stage 1 entailed
      instrument development and validation, which was achieved through a Delphi study 
      involving 11 expert panelists. The devised instrument included 64 six-point
      Likert items. In stage 2, a computer survey gathered data from a
      multidisciplinary, clinician group. METHODS: A total of 264 clinicians completed 
      the survey. Exploratory factor analysis with varimax rotation was used to
      validate the instrument, evaluate the factors, and summarize the explained
      variance achieved by sum scores of the perceptions and barriers scales. MAIN
      OUTCOME MEASURES: The perceptions scale was reduced to 23 items with a 6-factor
      solution explaining 67% of the variance with a good internal consistency
      reliability of 0.77 (Cronbach alpha). The 22-item barriers scale had a 6-factor
      solution explaining 71% of the variance with an alpha reliability of 0.83.
      PRINCIPLE RESULTS: The Perinatal Palliative Care Perceptions and Practice
      Barriers Scale instrument is a valid and reliable measure of PPC perceptions and 
      barriers for measuring the attitudes of physicians and nurses. CONCLUSION: Use of
      this instrument can foster educational programs and hospital planning for PPC
      teams that provide grieving families with the varied support they need. It is
      also a useful instrument for examining trends in the clinician perspectives and
      practice barriers as more genetic testing and subsequent terminal diagnoses
      occur.
FAU - Wool, Charlotte
AU  - Wool C
AD  - University of Texas at Tyler, USA. crwool@ycp.edu
FAU - Northam, Sally
AU  - Northam S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
PL  - United States
TA  - Adv Neonatal Care
JT  - Advances in neonatal care : official journal of the National Association of
      Neonatal Nurses
JID - 101125644
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Delphi Technique
MH  - Factor Analysis, Statistical
MH  - Female
MH  - Health Personnel/*psychology
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - Neonatology/*instrumentation
MH  - Palliative Care/*methods/psychology
MH  - Perinatal Care/*methods
MH  - Physicians/psychology
MH  - Pilot Projects
MH  - Pregnancy
MH  - *Professional-Patient Relations/ethics
MH  - Surveys and Questionnaires/standards
MH  - Terminal Care/psychology
EDAT- 2011/11/30 06:00
MHDA- 2012/05/02 06:00
CRDT- 2011/11/30 06:00
PHST- 2011/11/30 06:00 [entrez]
PHST- 2011/11/30 06:00 [pubmed]
PHST- 2012/05/02 06:00 [medline]
AID - 10.1097/ANC.0b013e318233809a [doi]
AID - 00149525-201112000-00008 [pii]
PST - ppublish
SO  - Adv Neonatal Care. 2011 Dec;11(6):397-403. doi: 10.1097/ANC.0b013e318233809a.


PMID- 22122558
OWN - NLM
STAT- MEDLINE
DCOM- 20121214
LR  - 20120806
IS  - 1471-6712 (Electronic)
IS  - 0283-9318 (Linking)
VI  - 26
IP  - 3
DP  - 2012 Sep
TI  - A qualitative study of depressive symptoms and well-being among first-time
      mothers.
PG  - 458-66
LID - 10.1111/j.1471-6712.2011.00950.x [doi]
AB  - BACKGROUND AND AIM: Ten to 15% of women experience postpartum depression.
      First-time mothers are particularly at risk. The present qualitative study aimed 
      to gain insight in terms of why some women find the transition of becoming a
      mother to be so emotionally taxing that they feel some level of depressed mood,
      while others feel mostly content after having a baby. METHOD: Semi-structured
      interviews were conducted with 12 self-selected first-time mothers. Participants 
      described their pregnancy and birth experience, expectations and experiences with
      regard to the postpartum period, social support and what they considered
      important with regard to well-being and depression in the postpartum period. Data
      were analysed by means of thematic analyses. Ethical approval was granted by the 
      Regional Ethics Committee. RESULTS: Two approaches to motherhood emerged, which
      we refer to as 'relaxed' and 'controlled'. These approaches influenced how the
      mothers had envisioned the postpartum period, their need for mastery and how they
      experienced it emotionally. Social support and managing breastfeeding stood out
      as important with regard to well-being and depressive symptoms. CONCLUSION:
      Frequent consultations with midwifes and public health nurses during the
      pregnancy and the postpartum period gives unique opportunities for preventive
      work. The consultations should to a greater extent focus on the woman's
      expectations and needs, and the partner should be present for an open discussion 
      on how they best support each other in this vulnerable period.
CI  - (c) 2011 The Authors. Scandinavian Journal of Caring Sciences (c) 2011 Nordic
      College of Caring Science.
FAU - Haga, Silje M
AU  - Haga SM
AD  - Department of Psychology, University of Oslo, Oslo, Norway.
      s.m.haga@psykologi.uio.no
FAU - Lynne, Anita
AU  - Lynne A
FAU - Slinning, Kari
AU  - Slinning K
FAU - Kraft, Pal
AU  - Kraft P
LA  - eng
PT  - Journal Article
DEP - 20111128
PL  - Sweden
TA  - Scand J Caring Sci
JT  - Scandinavian journal of caring sciences
JID - 8804206
MH  - Breast Feeding
MH  - Depression/*psychology
MH  - Female
MH  - Humans
MH  - Mothers/*psychology
MH  - Pregnancy
MH  - Qualitative Research
EDAT- 2011/11/30 06:00
MHDA- 2012/12/15 06:00
CRDT- 2011/11/30 06:00
PHST- 2011/11/30 06:00 [entrez]
PHST- 2011/11/30 06:00 [pubmed]
PHST- 2012/12/15 06:00 [medline]
AID - 10.1111/j.1471-6712.2011.00950.x [doi]
PST - ppublish
SO  - Scand J Caring Sci. 2012 Sep;26(3):458-66. doi: 10.1111/j.1471-6712.2011.00950.x.
      Epub 2011 Nov 28.


PMID- 22122336
OWN - NLM
STAT- MEDLINE
DCOM- 20120423
LR  - 20111129
IS  - 1750-192X (Electronic)
IS  - 1750-192X (Linking)
VI  - 3
IP  - 3
DP  - 2011 Jun
TI  - Environmental epigenomics and disease susceptibility. Keystone symposia on
      molecular and cellular biology. The Grove Park Hotel & Spa, Ashville, NC, USA, 27
      March-1 April 2011.
PG  - 261-6
LID - 10.2217/epi.11.25 [doi]
AB  - The main objective of this conference was to provide solid evidence that
      environmental exposures during early development can affect faithful reproduction
      of individual parental epigenomes without changing DNA sequence in the offspring.
      No doubt, this important goal has been successfully achieved owing to the high
      quality of presented epidemiological and experimental studies and engaging
      discussions of many yet to be published results. Compelling data suggested a
      strong causal link between prenatal vulnerability of future parental epigenomes
      to damaging environmental factors aggravated by abnormal socio-cultural
      conditions (including, for instance, malnutrition and chronic stress) and the
      alarming risk of developing heritable complex medical conditions later in life,
      such as asthma, autism, cancer, cardiovascular disease, diabetes, obesity,
      schizophrenia and a whole range of rare neuromuscular pathologies. It was
      concluded that modern epigenetic research promises to markedly improve our
      ability to diagnose, prevent and treat these and other pathological conditions of
      humans. However, the complex heritability pattern of 'epigenetic syndromes' also 
      introduces unique legal and ethical issues that were discussed at the end of this
      outstanding meeting.
FAU - Lobanenkov, Victor
AU  - Lobanenkov V
AD  - Molecular Pathology Section, Laboratory of Immunopathology, National Institutes
      of Allergy & Infectious Disease, Rockville, MD 20852, USA.
      vlobanenkov@niaid.nih.gov
FAU - Loukinov, Dmitry
AU  - Loukinov D
FAU - Pugacheva, Elena
AU  - Pugacheva E
LA  - eng
PT  - Journal Article
PL  - England
TA  - Epigenomics
JT  - Epigenomics
JID - 101519720
SB  - IM
MH  - *Congresses as Topic
MH  - Disease Susceptibility/*physiopathology
MH  - *Environmental Exposure
MH  - Epigenomics/*methods
MH  - *Gene-Environment Interaction
MH  - Humans
EDAT- 2011/11/30 06:00
MHDA- 2012/04/24 06:00
CRDT- 2011/11/30 06:00
PHST- 2011/11/30 06:00 [entrez]
PHST- 2011/11/30 06:00 [pubmed]
PHST- 2012/04/24 06:00 [medline]
AID - 10.2217/epi.11.25 [doi]
PST - ppublish
SO  - Epigenomics. 2011 Jun;3(3):261-6. doi: 10.2217/epi.11.25.


PMID- 22122028
OWN - NLM
STAT- MEDLINE
DCOM- 20120411
LR  - 20161021
IS  - 2044-8309 (Electronic)
IS  - 0144-6665 (Linking)
VI  - 50
IP  - 4
DP  - 2011 Dec
TI  - Are we all in this together?: co-victimization,inclusive social identity and
      collective action in solidarity with the disadvantaged.
PG  - 707-25
LID - 10.1111/j.2044-8309.2011.02073.x [doi]
AB  - Common experience of injustice can be a potent motivator of collective action and
      efforts to achieve social change - and of such efforts becoming more widespread. 
      In this research, we propose that the effects of co-victimization on collective
      action are a function of inclusive social identity. Experiment 1 (N= 61)
      demonstrated that while presence (compared to absence) of co-victimization
      positively predicted consumer (i.e., participants) willingness to act
      collectively in solidarity with sweatshop workers, this effect was mediated by
      inclusive social identity. In Experiment 2 (N= 120), the salience of inclusive
      social identity was experimentally manipulated and interacted with
      co-victimization to predict collective action. When inclusive social identity was
      salient, co-victimization enhanced collective action, including willingness to
      pay extra for products made ethically and in support of fair wages for workers.
      In contrast, collective action was attenuated when co-victimization took place in
      the absence of inclusive social identity. Implications for understanding when
      co-victimization is transformed into common fate and political solidarity with
      the disadvantaged are discussed.
CI  - (c)2011 The British Psychological Society.
FAU - Subasic, Emina
AU  - Subasic E
AD  - Australian National University, Canberra. emina.subasic@anu.edu.au
FAU - Schmitt, Michael T
AU  - Schmitt MT
FAU - Reynolds, Katherine J
AU  - Reynolds KJ
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Soc Psychol
JT  - The British journal of social psychology
JID - 8105534
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Cooperative Behavior
MH  - *Crime Victims
MH  - Female
MH  - *Goals
MH  - Humans
MH  - Male
MH  - *Social Identification
MH  - Social Justice
MH  - Vulnerable Populations
MH  - Young Adult
EDAT- 2011/11/30 06:00
MHDA- 2012/04/12 06:00
CRDT- 2011/11/30 06:00
PHST- 2011/11/30 06:00 [entrez]
PHST- 2011/11/30 06:00 [pubmed]
PHST- 2012/04/12 06:00 [medline]
AID - 10.1111/j.2044-8309.2011.02073.x [doi]
PST - ppublish
SO  - Br J Soc Psychol. 2011 Dec;50(4):707-25. doi: 10.1111/j.2044-8309.2011.02073.x.


PMID- 22055550
OWN - NLM
STAT- MEDLINE
DCOM- 20120312
LR  - 20161020
IS  - 1578-1283 (Electronic)
IS  - 0213-9111 (Linking)
VI  - 25 Suppl 1
DP  - 2011 Jun
TI  - [Health technology assessment in public health interventions: is prevention
      better than cure?].
PG  - 40-8
LID - 10.1016/S0213-9111(11)70007-3 [doi]
AB  - Medical activities are increasingly performed with preventive purposes, as part
      of community programs for secondary prevention but also as part of many clinical 
      activities. However, there are few evaluations of preventive and health promotion
      activities and, in general, these evaluations only assess aspects of
      efficacy/effectiveness with little consideration of cost and cost-effectiveness
      and even less of the ethical, legal, social or organizational consequences. Given
      the growing interest in evaluation of these interventions from different
      perspectives, health technology assessment (HTA) has emerged as a
      multidisciplinary analysis strategy with distinct methodological approaches that 
      may be useful to health administrations and policy-makers for decision making at 
      different levels (micro, meso and macro). This manuscript discusses the
      characteristics and differential aspects related to assessment of preventive and 
      health promotion activities. This type of evaluation poses constraints,
      limitations and challenges that should be considered during the process of HTA.
      In the case of public health there are additional challenges, because the
      evidence must satisfy a diverse audience, including public health professionals, 
      clinicians, politicians, managers, economists and consumers. The challenge is
      even greater when evaluating complex, integrated community interventions in which
      local and contextual aspects are of tremendous importance. In addition,
      assessment of ethical issues is of the utmost importance since these issues
      comprise the origin of health services and the target populations are usually
      healthy.
CI  - Copyright A(c) 2011 Sociedad Espanola de Salud Publica y Administracion
      Sanitaria. Published by Elsevier Espana. All rights reserved.
FAU - Espallargues, Mireia
AU  - Espallargues M
AD  - Agencia d'Informacio, Avaluacio i Qualitat en Salut (AIAQS), Servei Catala de la 
      Salut-CatSalut, Barcelona, Espana. mespallargues@aatrm.catsalut.cat
FAU - Pons, Joan M V
AU  - Pons JM
FAU - Almazan, Caridad
AU  - Almazan C
FAU - de Sola-Morales, Oriol
AU  - de Sola-Morales O
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
TT  - La evaluacion de tecnologias sanitarias en intervenciones de salud publica: mas
      vale prevenir que curar?
PL  - Spain
TA  - Gac Sanit
JT  - Gaceta sanitaria
JID - 8901623
SB  - IM
MH  - *Biomedical Technology/trends
MH  - Community Health Services/ethics/legislation & jurisprudence/organization &
      administration
MH  - Data Collection
MH  - Health Promotion/*organization & administration
MH  - Humans
MH  - Models, Theoretical
MH  - Preventive Health Services/ethics/legislation & jurisprudence/*organization &
      administration
MH  - Program Evaluation/*methods
MH  - *Public Health
MH  - *Research Design
MH  - Safety Management
MH  - Spain
EDAT- 2011/11/30 06:00
MHDA- 2012/03/13 06:00
CRDT- 2011/11/08 06:00
PHST- 2011/11/08 06:00 [entrez]
PHST- 2011/11/30 06:00 [pubmed]
PHST- 2012/03/13 06:00 [medline]
AID - S0213-9111(11)70007-3 [pii]
AID - 10.1016/S0213-9111(11)70007-3 [doi]
PST - ppublish
SO  - Gac Sanit. 2011 Jun;25 Suppl 1:40-8. doi: 10.1016/S0213-9111(11)70007-3.


PMID- 22121239
OWN - NLM
STAT- MEDLINE
DCOM- 20120913
LR  - 20220331
IS  - 1460-2385 (Electronic)
IS  - 0931-0509 (Linking)
VI  - 26
IP  - 12
DP  - 2011 Dec
TI  - The impact of culture and religion on truth telling at the end of life.
PG  - 3838-42
LID - 10.1093/ndt/gfr630 [doi]
AB  - Truth telling, a cardinal rule in Western medicine, is not a globally shared
      moral stance. Honest disclosure of terminal prognosis and diagnosis are regarded 
      as imperative in preparing for the end of life. Yet in many cultures, truth
      concealment is common practice. In collectivist Asian and Muslim cultures,
      illness is a shared family affair. Consequently, decision making is family
      centred and beneficence and non-malfeasance play a dominant role in their ethical
      model, in contrast to patient autonomy in Western cultures. The 'four principles'
      are prevalent throughout Eastern and Western cultures, however, the weight with
      which they are considered and their understanding differ. The belief that a grave
      diagnosis or prognosis will extinguish hope in patients leads families to protect
      ill members from the truth. This denial of the truth, however, is linked with not
      losing faith in a cure. Thus, aggressive futile treatment can be expected. The
      challenge is to provide a health care service that is equable for all individuals
      in a given country. The British National Health Service provides care to all
      cultures but is bound by the legal principles and framework of the UK and aims
      for equity of provision by working within the UK ethical framework with legal and
      ethical norms being explained to all patients and relatives. This requires truth 
      telling about prognosis and efficacy of potential treatments so that unrealistic 
      expectations are not raised.
FAU - de Pentheny O'Kelly, Clarissa
AU  - de Pentheny O'Kelly C
FAU - Urch, Catherine
AU  - Urch C
FAU - Brown, Edwina A
AU  - Brown EA
LA  - eng
PT  - Editorial
PT  - Review
PL  - England
TA  - Nephrol Dial Transplant
JT  - Nephrology, dialysis, transplantation : official publication of the European
      Dialysis and Transplant Association - European Renal Association
JID - 8706402
SB  - IM
MH  - *Attitude to Death
MH  - *Cultural Characteristics
MH  - Humans
MH  - Medical Futility
MH  - *Religion
MH  - *Truth Disclosure
EDAT- 2011/11/29 06:00
MHDA- 2012/09/14 06:00
CRDT- 2011/11/29 06:00
PHST- 2011/11/29 06:00 [entrez]
PHST- 2011/11/29 06:00 [pubmed]
PHST- 2012/09/14 06:00 [medline]
AID - gfr630 [pii]
AID - 10.1093/ndt/gfr630 [doi]
PST - ppublish
SO  - Nephrol Dial Transplant. 2011 Dec;26(12):3838-42. doi: 10.1093/ndt/gfr630.


PMID- 22120790
OWN - NLM
STAT- MEDLINE
DCOM- 20120315
LR  - 20111128
IS  - 1998-3646 (Electronic)
IS  - 0255-0857 (Linking)
VI  - 29
IP  - 4
DP  - 2011 Oct-Dec
TI  - Ethics in biotechnology and biosecurity.
PG  - 331-5
LID - 10.4103/0255-0857.90155 [doi]
AB  - Great advances in technology produce unique challenges. Every technology also has
      a dual use, which needs to be understood and managed to extract maximum benefits 
      for mankind and the development of civilization. The achievements of physicists
      in the mid-20th century resulted in the nuclear technology, which gave us the
      destructive power of the atomic bomb as also a source of energy. Towards the
      later part of the 20th century, information technology empowered us with fast,
      easy and cheap access to information, but also led to intrusions into our
      privacy. Today, biotechnology is yielding life- saving and life-enhancing
      advances at a fast pace. But, the same tools can also give rise to fiercely
      destructive forces. How do we construct a security regime for biology? What have 
      we learnt from the management of earlier technological advances? How much
      information should be in the public domain? Should biology, or more broadly
      science, be regulated? Who should regulate it? These and many other ethical
      questions need to be addressed.
FAU - Jameel, S
AU  - Jameel S
AD  - Senior Scientist and Group Leader, Virology Group, International Centre for
      Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi - 110 067, 
      India. jameelshahid@gmail.com
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Indian J Med Microbiol
JT  - Indian journal of medical microbiology
JID - 8700903
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Biotechnology/*ethics
MH  - Humans
MH  - United States
EDAT- 2011/11/29 06:00
MHDA- 2012/03/16 06:00
CRDT- 2011/11/29 06:00
PHST- 2011/11/29 06:00 [entrez]
PHST- 2011/11/29 06:00 [pubmed]
PHST- 2012/03/16 06:00 [medline]
AID - IndianJMedMicrobiol_2011_29_4_331_90155 [pii]
AID - 10.4103/0255-0857.90155 [doi]
PST - ppublish
SO  - Indian J Med Microbiol. 2011 Oct-Dec;29(4):331-5. doi: 10.4103/0255-0857.90155.


PMID- 22120789
OWN - NLM
STAT- MEDLINE
DCOM- 20120315
LR  - 20120727
IS  - 1998-3646 (Electronic)
IS  - 0255-0857 (Linking)
VI  - 29
IP  - 4
DP  - 2011 Oct-Dec
TI  - Ethical issues in microbiology.
PG  - 327-30
LID - 10.4103/0255-0857.90154 [doi]
AB  - Ethical issues facing microbiologists could be considered in two parts. The first
      relates to the way the ethical issues during their laboratory work. The second
      pertains to ethical issues on the data/reports they generate for the patients or 
      in research. In both segments, there is pressure to perform, which is exerted by 
      both, the community, as well as peers. It has therefore become increasingly
      necessary to recognize the facts that unethical actions might be a frequent
      reality. Since some of these activities generate serious ethical concerns, both
      in practice and research, it is necessary for microbiologists to be aware and
      equipped to meet these issues in a prepared and measured way. In an attempt to
      highlight this requirement, this article outlines the important ethical issues
      and guidelines relevant to the field of Microbiology.
FAU - Desikan, P
AU  - Desikan P
AD  - Department of Microbiology, Bhopal Memorial Hospital and Research Centre, Raisen 
      Bypass Road, Karond, Bhopal 462 038, Madhya Pradesh, India.
      prabhadesikan@yahoo.com
FAU - Chakrabarti, A
AU  - Chakrabarti A
FAU - Muthuswamy, V
AU  - Muthuswamy V
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Indian J Med Microbiol
JT  - Indian journal of medical microbiology
JID - 8700903
SB  - IM
CIN - Indian J Med Microbiol. 2012 Apr-Jun;30(2):249-50; author reply 250. PMID:
      22664452
MH  - Biomedical Research/*ethics/*methods
MH  - Clinical Laboratory Techniques/*ethics/*methods
MH  - Communicable Diseases/*diagnosis
MH  - Ethics, Professional
MH  - Ethics, Research
MH  - Humans
EDAT- 2011/11/29 06:00
MHDA- 2012/03/16 06:00
CRDT- 2011/11/29 06:00
PHST- 2011/11/29 06:00 [entrez]
PHST- 2011/11/29 06:00 [pubmed]
PHST- 2012/03/16 06:00 [medline]
AID - IndianJMedMicrobiol_2011_29_4_327_90154 [pii]
AID - 10.4103/0255-0857.90154 [doi]
PST - ppublish
SO  - Indian J Med Microbiol. 2011 Oct-Dec;29(4):327-30. doi: 10.4103/0255-0857.90154.


PMID- 22120766
OWN - NLM
STAT- MEDLINE
DCOM- 20120420
LR  - 20211021
IS  - 1432-1238 (Electronic)
IS  - 0342-4642 (Linking)
VI  - 38
IP  - 1
DP  - 2012 Jan
TI  - Designing and conducting a randomized trial for pandemic critical illness: the
      2009 H1N1 influenza pandemic.
PG  - 29-39
LID - 10.1007/s00134-011-2409-8 [doi]
AB  - PURPOSE: To analyze the hurdles in implementing a randomized trial of
      corticosteroids for severe 2009 H1N1 influenza infections. METHODS: This was an
      investigator-led, multicenter, randomized, placebo-controlled, double-blind trial
      of corticosteroids in ICU patients with 2009 H1N1 influenza pneumonia requiring
      mechanical ventilation. The feasibility of and hurdles in designing and
      initiating a phase III trial in a short-lived pandemic crisis were analyzed. The 
      regulatory agency and ethics committee approved the study's scientific,
      financial, and ethical aspects within 4 weeks. Hydrocortisone and placebo were
      prepared centrally and shipped to participating hospitals within 6 weeks. The
      inclusion period started on November 9, 2009. RESULTS: From August 1, 2009 to
      March 8, 2010, only 205/224 ICU patients with H1N1 infections required mechanical
      ventilation. The peak of the wave was missed by 2-3 weeks and only 26 patients
      were randomized. The two main reasons for non-inclusion were patients' admission 
      before the beginning of the trial and ICU personnel overwhelmed by clinical
      duties. Parallel rather than sequential regulatory and ethics approval, and
      preparation and masking of study drugs by local pharmacists would have allowed
      the study to start 1 month earlier and before the peak of the "flu" wave. A
      dedicated research team in each participating center would have increased the
      ratio of screened to randomized patients. CONCLUSION: This report highlights the 
      main hurdles in implementing a randomized trial for a pandemic critical illness
      and proposes solutions for future trials.
FAU - Annane, Djillali
AU  - Annane D
AD  - General ICU, Raymond Poincare Hospital, AP-HP, University of Versailles SQ, 104
      boulevard Raymond Poincare, 92380 Garches, France. djillali.annane@rpc.aphp.fr
FAU - Antona, Marion
AU  - Antona M
FAU - Lehmann, Blandine
AU  - Lehmann B
FAU - Kedzia, Cecile
AU  - Kedzia C
FAU - Chevret, Sylvie
AU  - Chevret S
CN  - CORTIFLU Investigators
CN  - CRICs
CN  - AZUREA
CN  - REVA/SRLF networks
LA  - eng
SI  - ClinicalTrials.gov/NCT01014364
PT  - Clinical Trial, Phase III
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20111126
PL  - United States
TA  - Intensive Care Med
JT  - Intensive care medicine
JID - 7704851
RN  - 0 (Adrenal Cortex Hormones)
SB  - IM
MH  - Adrenal Cortex Hormones/therapeutic use
MH  - Critical Illness
MH  - Double-Blind Method
MH  - Ethics, Research
MH  - Female
MH  - Humans
MH  - *Influenza A Virus, H1N1 Subtype
MH  - Influenza, Human/drug therapy/*epidemiology/virology
MH  - Male
MH  - Prospective Studies
MH  - *Research Design
MH  - Severity of Illness Index
IR  - Annane D
FIR - Annane, Djillali
IR  - Chevret S
FIR - Chevret, Sylvie
IR  - Chevret S
FIR - Chevret, Sylvie
IR  - Lejeune J
FIR - Lejeune, Julie
IR  - Annane D
FIR - Annane, Djillali
IR  - Chevret S
FIR - Chevret, Sylvie
IR  - Brun Bussion C
FIR - Brun Bussion, Christian
IR  - Mayaud C
FIR - Mayaud, Charles
IR  - Perronne C
FIR - Perronne, Christian
IR  - Regnier B
FIR - Regnier, Bernard
IR  - Kedzia C
FIR - Kedzia, Cecile
IR  - Beghoul N
FIR - Beghoul, Nabil
IR  - Lehmann B
FIR - Lehmann, Blandine
IR  - Annane D
FIR - Annane, Djillali
IR  - Pozzi D
FIR - Pozzi, Delphine
IR  - Brun Buisson C
FIR - Brun Buisson, Christian
IR  - Verlinde-Carvalho M
FIR - Verlinde-Carvalho, Muriel
IR  - Misset B
FIR - Misset, Benoit
IR  - Tersen I
FIR - Tersen, Isabelle
IR  - Mira JP
FIR - Mira, Jean Paul
IR  - Guerin C
FIR - Guerin, Corine
IR  - Chasttre J
FIR - Chasttre, Jean
IR  - Fievet H
FIR - Fievet, Helene
IR  - Brivet F
FIR - Brivet, Francois
IR  - Foucher S
FIR - Foucher, Severine
IR  - Ricome JL
FIR - Ricome, Jean-Louis
IR  - Merian-Brosse L
FIR - Merian-Brosse, Laurence
IR  - Bohe J
FIR - Bohe, Julien
IR  - Rioufol C
FIR - Rioufol, Catherine
IR  - Jonquet O
FIR - Jonquet, Olivier
IR  - Collard F
FIR - Collard, Florence
IR  - Timsit JF
FIR - Timsit, Jean-Francois
IR  - Chorfa L
FIR - Chorfa, Lilia
IR  - Siami S
FIR - Siami, Shidasp
IR  - Fontagnieres D
FIR - Fontagnieres, Dominique
IR  - Levy B
FIR - Levy, Bruno
IR  - Slama M
FIR - Slama, Michel
IR  - Petit A
FIR - Petit, Abir
IR  - Leroy O
FIR - Leroy, Olivier
IR  - Dubar V
FIR - Dubar, Veronique
IR  - Capellier G
FIR - Capellier, Gilles
IR  - Essert M
FIR - Essert, Michelle
IR  - Wolf M
FIR - Wolf, Michel
IR  - Arnaud P
FIR - Arnaud, Philippe
IR  - Martinet O
FIR - Martinet, Olivier
IR  - Chagnon JL
FIR - Chagnon, Jean-Luc
IR  - Dautel D
FIR - Dautel, Dominique
IR  - Claude M
FIR - Claude, Martin
IR  - Charbit M
FIR - Charbit, Martine
IR  - Loriferne JF
FIR - Loriferne, Jean-Francois
IR  - Passe P
FIR - Passe, Philippe
IR  - Ichai C
FIR - Ichai, Carole
IR  - Karchen I
FIR - Karchen, Isabelle
IR  - Petitpas F
FIR - Petitpas, Franck
IR  - Princet I
FIR - Princet, Isabelle
IR  - Dupont M
FIR - Dupont, Marc
IR  - Provitolo V
FIR - Provitolo, Vincent
IR  - Bollaert PE
FIR - Bollaert, Pierre Edouard
IR  - Medkour-Hassani K
FIR - Medkour-Hassani, Kahina
IR  - Leon A
FIR - Leon, Alain
IR  - Frances C
FIR - Frances, Carole
IR  - Constantin JM
FIR - Constantin, Jean-Michel
IR  - Corny S
FIR - Corny, Sandrine
IR  - Mayaud C
FIR - Mayaud, Charles
IR  - Guessant S
FIR - Guessant, Sabine
IR  - Alvarez A
FIR - Alvarez, Antonio
IR  - Edrief S
FIR - Edrief, Sophia
IR  - Dhonneur G
FIR - Dhonneur, Gilles
IR  - Benabadji Z
FIR - Benabadji, Zahira
IR  - Brends F
FIR - Brends, Francois
IR  - Souweine
FIR - Souweine
IR  - Corny S
FIR - Corny, Sandrine
IR  - Forceville X
FIR - Forceville, Xavier
IR  - Perrot F
FIR - Perrot, Francoise
IR  - Megarbane B
FIR - Megarbane, Bruno
IR  - Rizzopadoin
FIR - Rizzopadoin
IR  - Reignier J
FIR - Reignier, Jean
IR  - Poirier Y
FIR - Poirier, Yannick
IR  - Santoli F
FIR - Santoli, Francesco
IR  - Duperrin V
FIR - Duperrin, Veronique
IR  - Mercat A
FIR - Mercat, Alain
IR  - Daniel V
FIR - Daniel, Valerie
IR  - Allaouchiche B
FIR - Allaouchiche, Bernard
IR  - Guidet B
FIR - Guidet, Bertrand
IR  - Robert R
FIR - Robert, Rene
IR  - Cohen Y
FIR - Cohen, Yves
IR  - Azoulay E
FIR - Azoulay, Elie
IR  - Touratier S
FIR - Touratier, Sophie
IR  - Jabert-Jaber S
FIR - Jabert-Jaber, Samir
IR  - Jung B
FIR - Jung, Boris
IR  - Allaz JL
FIR - Allaz, Jean-Luc
IR  - Lefrant JY
FIR - Lefrant, Jean-Yves
IR  - Richard C
FIR - Richard, Christian
IR  - Taburet AM
FIR - Taburet, Anne Marie
IR  - Diehl JL
FIR - Diehl, Jean Luc
IR  - Sabatier B
FIR - Sabatier, Brigitte
IR  - Thiolliere F
FIR - Thiolliere, Fabrice
IR  - Radideau E
FIR - Radideau, Emmanuelle
IR  - Rabbat A
FIR - Rabbat, Antoine
IR  - Batista
FIR - Batista
IR  - Fourrier F
FIR - Fourrier, Francois
IR  - Thielemans B
FIR - Thielemans, Beatrice
IR  - Zeni F
FIR - Zeni, Fabrice
IR  - Marchand M
FIR - Marchand, Martial
IR  - Argaud L
FIR - Argaud, Laurent
IR  - Pivot C
FIR - Pivot, Christine
IR  - Pallot JL
FIR - Pallot, Jean-Louis
IR  - Tacco F
FIR - Tacco, Frederic
IR  - Duguet A
FIR - Duguet, Alexandre
IR  - Fievet H
FIR - Fievet, Helene
IR  - Descorps-Declere A
FIR - Descorps-Declere, Adrien
IR  - Foucher S
FIR - Foucher, Severine
IR  - Charpentier C
FIR - Charpentier, Claire
IR  - Medkour-Hassani K
FIR - Medkour-Hassani, Kahina
IR  - Bedos JP
FIR - Bedos, Jean-Pierre
IR  - Chaumont M
FIR - Chaumont, Marie
IR  - Letulzo Y
FIR - Letulzo, Yves
IR  - Hamon C
FIR - Hamon, Catherine
EDAT- 2011/11/29 06:00
MHDA- 2012/04/21 06:00
CRDT- 2011/11/29 06:00
PHST- 2011/05/08 00:00 [received]
PHST- 2011/08/02 00:00 [accepted]
PHST- 2011/11/29 06:00 [entrez]
PHST- 2011/11/29 06:00 [pubmed]
PHST- 2012/04/21 06:00 [medline]
AID - 10.1007/s00134-011-2409-8 [doi]
PST - ppublish
SO  - Intensive Care Med. 2012 Jan;38(1):29-39. doi: 10.1007/s00134-011-2409-8. Epub
      2011 Nov 26.


PMID- 22120395
OWN - NLM
STAT- MEDLINE
DCOM- 20120607
LR  - 20211021
IS  - 1878-8769 (Electronic)
IS  - 1878-8750 (Linking)
VI  - 77
IP  - 2
DP  - 2012 Feb
TI  - "Any possible restoration of function could not occur": Harvey Cushing and the
      early description of brain death.
PG  - 394-7
LID - 10.1016/j.wneu.2011.04.016 [doi]
AB  - OBJECTIVES: To describe a case from 1908 of apparent brain death after operative 
      intervention by Harvey Cushing at the Johns Hopkins Hospital. METHODS: After
      institutional review board approval, which waived the requirement of informed
      consent from patients, and through the courtesy of the Alan Mason Chesney
      Archives, we reviewed the Johns Hopkins Hospital surgical files from 1896 to
      1912. RESULTS: We selected a single adult patient operated upon by Cushing, whose
      respirations ceased in the operating room and who was maintained by the use of
      artificial respiration via a tracheostomy during a 36-hour period, whereas
      further surgical interventions were performed in an attempt to improve his
      condition. The patient's condition remained unimproved; artificial respirations
      were discontinued and the "cessation of all cardiac activity" was observed.
      CONCLUSIONS: Brain death is a concept that presents unique challenges to the
      practicing physician. Although recent advances have allowed for better diagnosis 
      of brain death, the topic remains fraught with controversy. The case described
      here documents Harvey Cushing's struggles with the ethics of maintaining vital
      organ function with artificial respiration, despite clear evidence of
      irreversible ischemic brain damage. This case predates the earliest descriptions 
      of brain death by more than 50 years and illustrates the dilemmas facing
      clinicians at the turn of the twentieth century.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Pendleton, Courtney
AU  - Pendleton C
AD  - Department of Neurosurgery, The Johns Hopkins University School of Medicine,
      Baltimore, Maryland, USA.
FAU - Jiang, Bowen
AU  - Jiang B
FAU - Geocadin, Romergryko G
AU  - Geocadin RG
FAU - Quinones-Hinojosa, Alfredo
AU  - Quinones-Hinojosa A
LA  - eng
GR  - P30 CA006973/CA/NCI NIH HHS/United States
PT  - Case Reports
PT  - Historical Article
PT  - Journal Article
DEP - 20111107
PL  - United States
TA  - World Neurosurg
JT  - World neurosurgery
JID - 101528275
SB  - IM
CIN - World Neurosurg. 2012 Feb;77(2):296-7. PMID: 22120369
CIN - World Neurosurg. 2012 Feb;77(2):298-9. PMID: 22120381
MH  - Adult
MH  - Anesthesia
MH  - Brain Death/*diagnosis/physiopathology
MH  - Craniocerebral Trauma/complications
MH  - Craniotomy
MH  - Electric Stimulation
MH  - History, 20th Century
MH  - Humans
MH  - Male
MH  - Neurology/*history
MH  - Neurosurgery/*history
MH  - Respiration, Artificial
MH  - Temporal Lobe/pathology
MH  - Tracheostomy
PMC - PMC4618458
MID - NIHMS729487
EDAT- 2011/11/29 06:00
MHDA- 2012/06/08 06:00
CRDT- 2011/11/29 06:00
PHST- 2010/12/02 00:00 [received]
PHST- 2011/04/07 00:00 [revised]
PHST- 2011/04/19 00:00 [accepted]
PHST- 2011/11/29 06:00 [entrez]
PHST- 2011/11/29 06:00 [pubmed]
PHST- 2012/06/08 06:00 [medline]
AID - S1878-8750(11)00494-3 [pii]
AID - 10.1016/j.wneu.2011.04.016 [doi]
PST - ppublish
SO  - World Neurosurg. 2012 Feb;77(2):394-7. doi: 10.1016/j.wneu.2011.04.016. Epub 2011
      Nov 7.


PMID- 22120151
OWN - NLM
STAT- MEDLINE
DCOM- 20130424
LR  - 20121112
IS  - 1573-6814 (Electronic)
IS  - 1389-9333 (Linking)
VI  - 13
IP  - 4
DP  - 2012 Dec
TI  - A model of a code of ethics for tissue banks operating in developing countries.
PG  - 607-22
LID - 10.1007/s10561-011-9279-8 [doi]
AB  - Ethical practice in the field of tissue banking requires the setting of
      principles, the identification of possible deviations and the establishment of
      mechanisms that will detect and hinder abuses that may occur during the
      procurement, processing and distribution of tissues for transplantation. This
      model of a Code of Ethics has been prepared with the purpose of being used for
      the elaboration of a Code of Ethics for tissue banks operating in the Latin
      American and the Caribbean, Asia and the Pacific and the African regions in order
      to guide the day-to-day operation of these banks. The purpose of this model of
      Code of Ethics is to assist interested tissue banks in the preparation of their
      own Code of Ethics towards ensuring that the tissue bank staff support with their
      actions the mission and values associated with tissue banking.
FAU - Morales Pedraza, Jorge
AU  - Morales Pedraza J
AD  - University Diplomas in Mathematics and Economy, Vienna, Austria.
      jmorales47@hotmail.com
LA  - eng
PT  - Journal Article
DEP - 20111127
PL  - Netherlands
TA  - Cell Tissue Bank
JT  - Cell and tissue banking
JID - 100965121
SB  - IM
MH  - Clinical Coding/ethics
MH  - *Codes of Ethics
MH  - *Developing Countries
MH  - Ethics Committees
MH  - Humans
MH  - International Agencies/ethics
MH  - Tissue Banks/*ethics
MH  - Tissue Donors/ethics
EDAT- 2011/11/29 06:00
MHDA- 2013/04/25 06:00
CRDT- 2011/11/29 06:00
PHST- 2011/06/10 00:00 [received]
PHST- 2011/10/11 00:00 [accepted]
PHST- 2011/11/29 06:00 [entrez]
PHST- 2011/11/29 06:00 [pubmed]
PHST- 2013/04/25 06:00 [medline]
AID - 10.1007/s10561-011-9279-8 [doi]
PST - ppublish
SO  - Cell Tissue Bank. 2012 Dec;13(4):607-22. doi: 10.1007/s10561-011-9279-8. Epub
      2011 Nov 27.


PMID- 22119159
OWN - NLM
STAT- MEDLINE
DCOM- 20120622
LR  - 20120224
IS  - 1879-3096 (Electronic)
IS  - 0167-7799 (Linking)
VI  - 30
IP  - 3
DP  - 2012 Mar
TI  - Synthetic biology confronts publics and policy makers: challenges for
      communication, regulation and commercialization.
PG  - 132-7
LID - 10.1016/j.tibtech.2011.10.003 [doi]
AB  - The novelty of synthetic biology lies in the use of synthesized parts that can be
      arranged to make useful products. Such advanced, high-throughput genetic
      engineering projects redesign and fabricate existing biological systems as well
      as new biological parts, devices and systems that do not occur in nature. This
      Opinion discusses challenges raised by synthetic biology for public acceptance,
      regulation, commercialization and the emerging global issue of access to genetic 
      resources and information. As with all new fields of research, maintaining the
      trust of the public and policy regulators is paramount. Hype and exaggerated
      claims are counterproductive to developing adaptive and ethically sound
      regulatory models responsive to stakeholder concerns.
CI  - Copyright (c) 2011. Published by Elsevier Ltd.
FAU - Bubela, Tania
AU  - Bubela T
AD  - Department of Public Health Sciences, School of Public Health, University of
      Alberta, Edmonton Clinic Health Academy, 11405-87 Avenue, Edmonton, Alberta,
      Canada, T6G 1C9. tbubela@ualberta.ca
FAU - Hagen, Gregory
AU  - Hagen G
FAU - Einsiedel, Edna
AU  - Einsiedel E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111125
PL  - England
TA  - Trends Biotechnol
JT  - Trends in biotechnology
JID - 8310903
SB  - IM
MH  - Genetic Techniques
MH  - Guidelines as Topic
MH  - Humans
MH  - Synthetic Biology/*ethics/*legislation & jurisprudence/trends
EDAT- 2011/11/29 06:00
MHDA- 2012/06/23 06:00
CRDT- 2011/11/29 06:00
PHST- 2011/08/04 00:00 [received]
PHST- 2011/10/17 00:00 [revised]
PHST- 2011/10/21 00:00 [accepted]
PHST- 2011/11/29 06:00 [entrez]
PHST- 2011/11/29 06:00 [pubmed]
PHST- 2012/06/23 06:00 [medline]
AID - S0167-7799(11)00180-6 [pii]
AID - 10.1016/j.tibtech.2011.10.003 [doi]
PST - ppublish
SO  - Trends Biotechnol. 2012 Mar;30(3):132-7. doi: 10.1016/j.tibtech.2011.10.003. Epub
      2011 Nov 25.


PMID- 22118422
OWN - NLM
STAT- MEDLINE
DCOM- 20130426
LR  - 20121107
IS  - 1464-5351 (Electronic)
IS  - 1369-1058 (Linking)
VI  - 14 Suppl 1
DP  - 2012
TI  - 'The vagina does not talk': conception concealed or deliberately disclosed in
      eastern Cameroon.
PG  - S81-94
LID - 10.1080/13691058.2011.634925 [doi]
AB  - In the East Province of Cameroon, respectable womanhood has long been
      intrinsically related to ethics of production and reproduction: women attain
      social standing through productive work in the fields and through the
      reproduction of children - preferably within a marital setting. Yet, in the face 
      of current alternative 'horizons of honour' such as schooling, employment or
      relationships with rich urban men, women's intentions with regard to marriage and
      motherhood acquire different meanings. On their pathways to urban forms of
      honour, formal engagements and childbearing are often postponed, while premarital
      sexual encounters proliferate. This paper explores the meanings of pregnancy
      within the context of these fragile relationships and women's urban aspirations; 
      fertility will be shown to be a 'bet' that may either disrupt or stabilize urban 
      affairs and ambitions. As such, pregnancies can be strategically anticipated and 
      deliberately disclosed or unexpectedly encountered and secretly disrupted. This
      paper sheds light on women's strategies of concealment and disclosure of
      pregnancies and shows that these practices are often inspired by a notion of the 
      'right timing' of particular reproductive conjunctures - a notion that is of
      increasing relevance in current frames of female honour in Cameroon.
FAU - van der Sijpt, Erica
AU  - van der Sijpt E
AD  - Amsterdam Institute for Social Science Research, University of Amsterdam,
      Amsterdam, The Netherlands. E.vanderSijpt@uva.nl
LA  - eng
PT  - Journal Article
DEP - 20111128
PL  - England
TA  - Cult Health Sex
JT  - Culture, health & sexuality
JID - 100883416
SB  - IM
MH  - Adult
MH  - Attitude to Health/*ethnology
MH  - Cameroon
MH  - *Cultural Characteristics
MH  - Female
MH  - Humans
MH  - *Interpersonal Relations
MH  - Male
MH  - Pregnancy/*psychology
MH  - *Self Disclosure
MH  - Social Perception
MH  - Social Stigma
MH  - Socioeconomic Factors
MH  - Vagina
MH  - Women's Health/*ethnology
MH  - Young Adult
EDAT- 2011/11/29 06:00
MHDA- 2013/04/27 06:00
CRDT- 2011/11/29 06:00
PHST- 2011/11/29 06:00 [entrez]
PHST- 2011/11/29 06:00 [pubmed]
PHST- 2013/04/27 06:00 [medline]
AID - 10.1080/13691058.2011.634925 [doi]
PST - ppublish
SO  - Cult Health Sex. 2012;14 Suppl 1:S81-94. doi: 10.1080/13691058.2011.634925. Epub 
      2011 Nov 28.


PMID- 22118160
OWN - NLM
STAT- MEDLINE
DCOM- 20120328
LR  - 20181201
IS  - 1815-7920 (Electronic)
IS  - 1027-3719 (Linking)
VI  - 15
IP  - 12
DP  - 2011 Dec
TI  - The ethics of national tuberculosis programmes in low-income countries not
      rolling out Xpert (R) MTB/RIF.
PG  - 1563
LID - 10.5588/ijtld.11.0728 [doi]
FAU - Singh, Jerome Amir
AU  - Singh JA
FAU - Bhan, Anant
AU  - Bhan A
LA  - eng
PT  - Editorial
PT  - Comment
PL  - France
TA  - Int J Tuberc Lung Dis
JT  - The international journal of tuberculosis and lung disease : the official journal
      of the International Union against Tuberculosis and Lung Disease
JID - 9706389
RN  - 0 (Antitubercular Agents)
RN  - VJT6J7R4TR (Rifampin)
SB  - IM
CON - Int J Tuberc Lung Dis. 2011 Dec;15(12):1567-72. PMID: 22005110
MH  - Antitubercular Agents/*pharmacology
MH  - Humans
MH  - Nucleic Acid Amplification Techniques/*methods
MH  - Rifampin/*pharmacology
MH  - Tuberculosis/*diagnosis
EDAT- 2011/11/29 06:00
MHDA- 2012/03/29 06:00
CRDT- 2011/11/29 06:00
PHST- 2011/11/29 06:00 [entrez]
PHST- 2011/11/29 06:00 [pubmed]
PHST- 2012/03/29 06:00 [medline]
AID - 10.5588/ijtld.11.0728 [doi]
PST - ppublish
SO  - Int J Tuberc Lung Dis. 2011 Dec;15(12):1563. doi: 10.5588/ijtld.11.0728.


PMID- 22117755
OWN - NLM
STAT- MEDLINE
DCOM- 20120410
LR  - 20220330
IS  - 1532-8635 (Electronic)
IS  - 1524-9042 (Linking)
VI  - 12
IP  - 4
DP  - 2011 Dec
TI  - Pain assessment in the patient unable to self-report: position statement with
      clinical practice recommendations.
PG  - 230-50
LID - 10.1016/j.pmn.2011.10.002 [doi]
AB  - Individuals who are unable to communicate their pain are at greater risk for
      under recognition and undertreatment of pain. This position paper describes the
      magnitude of this issue, defines populations at risk and offers clinical practice
      recommendations for appropriate pain assessment using a hierarchical framework
      for assessing pain in those unable to self-report. Nurses have a moral, ethical, 
      and professional obligation to advocate for all individuals in their care,
      particularly those who are vulnerable and unable to speak for themselves. Just
      like all other patients, these special populations require consistent, ongoing
      assessment, appropriate treatment, and evaluation of interventions to insure the 
      best possible pain relief. Because of continued advances and new developments in 
      strategies and tools for assessing pain in these populations, clinicians are
      encouraged to stay current through regular review of new research and practice
      recommendations.
FAU - Herr, Keela
AU  - Herr K
AD  - John A. Hartford Center of Geriatric Nursing Excellence, University of Iowa
      College of Nursing, Iowa City, Iowa 52242, USA. keela-herr@uiowa.edu
FAU - Coyne, Patrick J
AU  - Coyne PJ
FAU - McCaffery, Margo
AU  - McCaffery M
FAU - Manworren, Renee
AU  - Manworren R
FAU - Merkel, Sandra
AU  - Merkel S
LA  - eng
PT  - Consensus Development Conference
PT  - Journal Article
PL  - United States
TA  - Pain Manag Nurs
JT  - Pain management nursing : official journal of the American Society of Pain
      Management Nurses
JID - 100890606
SB  - IM
MH  - Aged
MH  - Child, Preschool
MH  - Communication Barriers
MH  - Dementia/nursing
MH  - Humans
MH  - Infant
MH  - Pain/*nursing
MH  - *Pain Management/ethics/nursing/standards
MH  - *Practice Guidelines as Topic
MH  - Self Report
MH  - Societies, Nursing/*standards
MH  - Specialties, Nursing/ethics/standards
EDAT- 2011/11/29 06:00
MHDA- 2012/04/11 06:00
CRDT- 2011/11/29 06:00
PHST- 2011/08/20 00:00 [received]
PHST- 2011/08/22 00:00 [accepted]
PHST- 2011/11/29 06:00 [entrez]
PHST- 2011/11/29 06:00 [pubmed]
PHST- 2012/04/11 06:00 [medline]
AID - S1524-9042(11)00188-3 [pii]
AID - 10.1016/j.pmn.2011.10.002 [doi]
PST - ppublish
SO  - Pain Manag Nurs. 2011 Dec;12(4):230-50. doi: 10.1016/j.pmn.2011.10.002.


PMID- 22117671
OWN - NLM
STAT- MEDLINE
DCOM- 20120110
LR  - 20191210
IS  - 1878-3570 (Electronic)
IS  - 0002-8223 (Linking)
VI  - 111
IP  - 12
DP  - 2011 Dec
TI  - Nutrition professionals are obligated to follow ethical guidelines when
      conducting industry-funded research.
PG  - 1931-2
LID - 10.1016/j.jada.2011.10.014 [doi]
AB  - Although disclosure of all funding sources, including those from industry, is
      mandatory for publication, it is no longer adequate. Given the skepticism
      surrounding industry-funded research, we need guidelines for communication with
      funding organizations and publication venues, and we need to safeguard and
      preserve research and scientific integrity.
FAU - Nicklas, Theresa A
AU  - Nicklas TA
AD  - Baylor College of Medicine, Department of Pediatrics, Houston, TX, USA.
FAU - Karmally, Wahida
AU  - Karmally W
FAU - O'Neil, Carol E
AU  - O'Neil CE
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Diet Assoc
JT  - Journal of the American Dietetic Association
JID - 7503061
SB  - IM
MH  - *Capital Financing
MH  - Conflict of Interest
MH  - Conflict, Psychological
MH  - Dietetics/*ethics
MH  - *Ethics, Research
MH  - Food Industry/economics/*ethics/standards
MH  - Guidelines as Topic
MH  - Humans
MH  - Nutritional Sciences/*ethics/standards
MH  - *Research/economics/standards
EDAT- 2011/11/29 06:00
MHDA- 2012/01/11 06:00
CRDT- 2011/11/29 06:00
PHST- 2011/10/07 00:00 [received]
PHST- 2011/11/29 06:00 [entrez]
PHST- 2011/11/29 06:00 [pubmed]
PHST- 2012/01/11 06:00 [medline]
AID - S0002-8223(11)01758-5 [pii]
AID - 10.1016/j.jada.2011.10.014 [doi]
PST - ppublish
SO  - J Am Diet Assoc. 2011 Dec;111(12):1931-2. doi: 10.1016/j.jada.2011.10.014.


PMID- 22116568
OWN - NLM
STAT- MEDLINE
DCOM- 20120416
LR  - 20191027
IS  - 1710-2774 (Print)
IS  - 1710-2774 (Linking)
VI  - 14
IP  - 4
DP  - 2011
TI  - Checklist to meet ethical and legal obligations to critically ill patients at the
      end of life.
PG  - 60-6
AB  - Despite improvements in communication, errors in end-of-life care continue to be 
      made. For example, healthcare professionals may take direction from the wrong
      substitute decision-maker, or from family members when the patient is capable;
      permit families to propose treatment plans; conflate values and beliefs with
      prior expressed wishes or fail to inquire about prior expressed wishes. Sometimes
      healthcare professionals know what prior expressed wishes are but do not respect 
      them; others do not believe they have enough time to have an end-of-life
      discussion or lack the confidence, willingness and skills to manage one. As has
      been shown in initiatives to improve in surgical safety, the use of a checklist
      presents opportunities to potentially minimize common mistakes and errors. When
      engaging in end-of-life care, a checklist can help focus on what needs to be
      communicated rather than how it needs to be communicated. We propose a checklist 
      to support healthcare professionals in meeting their ethical and legal
      obligations to patients at the end of life. The checklist should minimize common 
      mistakes, and in situations where irreconcilable conflict is unavoidable, it will
      ensure that both healthcare teams and family members are informed and prepared.
FAU - Sibbald, Robert W
AU  - Sibbald RW
AD  - Department of Family Medicine, Schulich School of Medicine and Dentistry,
      University of Western Ontario, London, Ontario. robert.sibbald@lhsc.on.ca
FAU - Chidwick, Paula
AU  - Chidwick P
FAU - Handelman, Mark
AU  - Handelman M
FAU - Cooper, Andrew B
AU  - Cooper AB
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Canada
TA  - Healthc Q
JT  - Healthcare quarterly (Toronto, Ont.)
JID - 101208192
MH  - Aged, 80 and over
MH  - Checklist/*methods
MH  - Critical Illness/*therapy
MH  - Female
MH  - Humans
MH  - Informed Consent
MH  - Patient Care Planning/ethics/legislation & jurisprudence
MH  - Resuscitation Orders/ethics/legislation & jurisprudence
MH  - Terminal Care/*ethics/legislation & jurisprudence
MH  - Third-Party Consent/ethics/legislation & jurisprudence
EDAT- 2011/11/26 06:00
MHDA- 2012/04/17 06:00
CRDT- 2011/11/26 06:00
PHST- 2011/11/26 06:00 [entrez]
PHST- 2011/11/26 06:00 [pubmed]
PHST- 2012/04/17 06:00 [medline]
AID - 10.12927/hcq.2011.22652 [doi]
PST - ppublish
SO  - Healthc Q. 2011;14(4):60-6. doi: 10.12927/hcq.2011.22652.


PMID- 22116565
OWN - NLM
STAT- MEDLINE
DCOM- 20120416
LR  - 20191027
IS  - 1710-2774 (Print)
IS  - 1710-2774 (Linking)
VI  - 14
IP  - 4
DP  - 2011
TI  - Optimizing healthcare access: through the alignment of economic and ethical
      imperatives.
PG  - 44-6
AB  - The inability to fluidly seam the many "players" in the value chain from bench to
      bedside imparts resource wasting that compromises the universal access of
      Canadians to healthcare provision. In this article, these players, each of whom
      represents an essential access point in our healthcare continuum, are introduced 
      and briefly discussed.
FAU - Slavcev, Roderick A
AU  - Slavcev RA
AD  - University of Waterloo, School of Pharmacy, Kitchener, Ontario.
      slavcev@uwaterloo.ca
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Healthc Q
JT  - Healthcare quarterly (Toronto, Ont.)
JID - 101208192
MH  - Canada
MH  - Delivery of Health Care/legislation & jurisprudence/organization & administration
MH  - Delivery of Health Care, Integrated
MH  - Drug Industry
MH  - *Health Services Accessibility/economics/ethics
MH  - Humans
EDAT- 2011/11/26 06:00
MHDA- 2012/04/17 06:00
CRDT- 2011/11/26 06:00
PHST- 2011/11/26 06:00 [entrez]
PHST- 2011/11/26 06:00 [pubmed]
PHST- 2012/04/17 06:00 [medline]
AID - 10.12927/hcq.2013.22650 [doi]
PST - ppublish
SO  - Healthc Q. 2011;14(4):44-6. doi: 10.12927/hcq.2013.22650.


PMID- 22116564
OWN - NLM
STAT- MEDLINE
DCOM- 20120416
LR  - 20191027
IS  - 1710-2774 (Print)
IS  - 1710-2774 (Linking)
VI  - 14
IP  - 4
DP  - 2011
TI  - Priority setting in Ontario's LHINs: ethics and economics in action.
PG  - 35-43
AB  - Healthcare organizations the world over are faced with having to set priorities
      and allocate resources within the constraint of a fixed envelope of funding.
      Drawing on economic principles of value for money and ethical principles of fair 
      process, a priority setting framework was developed for Ontario's local health
      integration networks (LHINs) in late 2007 and early 2008. Subsequently, over an
      18-month period, the framework was piloted in three LHINs. In this article, the
      framework and pilot implementations are described, results from a formal
      evaluation are outlined and recommendations for future use are highlighted.
FAU - Gibson, Jennifer
AU  - Gibson J
AD  - Joint Centre for Bioethics and the Department of Health Policy, Management, and
      Evaluation, University of Toronto, Toronto, Ontario. jennifer.gibson@utoronto.ca
FAU - Mitton, Craig
AU  - Mitton C
FAU - DuBois-Wing, Gwen
AU  - DuBois-Wing G
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Healthc Q
JT  - Healthcare quarterly (Toronto, Ont.)
JID - 101208192
CIN - Healthc Q. 2011;14(4):14. PMID: 22220329
MH  - *Community Networks/economics/ethics/organization & administration
MH  - *Health Priorities/economics/ethics/organization & administration
MH  - Humans
MH  - Models, Organizational
MH  - Ontario
MH  - Policy Making
MH  - Program Development
MH  - Program Evaluation
EDAT- 2011/11/26 06:00
MHDA- 2012/04/17 06:00
CRDT- 2011/11/26 06:00
PHST- 2011/11/26 06:00 [entrez]
PHST- 2011/11/26 06:00 [pubmed]
PHST- 2012/04/17 06:00 [medline]
AID - 10.12927/hcq.2011.22649 [doi]
PST - ppublish
SO  - Healthc Q. 2011;14(4):35-43. doi: 10.12927/hcq.2011.22649.


PMID- 22116254
OWN - NLM
STAT- MEDLINE
DCOM- 20120427
LR  - 20151119
IS  - 1476-5373 (Electronic)
IS  - 0007-0610 (Linking)
VI  - 211
IP  - 10
DP  - 2011 Nov 25
TI  - Treating patients with dry mouth: general dental practitioners' knowledge,
      attitudes and clinical management.
PG  - E21
LID - 10.1038/sj.bdj.2011.966 [doi]
AB  - AIM: To assess primary care dental practitioners' knowledge, attitudes and
      clinical management of patients presenting with dry mouth. METHOD: A convenience 
      sample of 200 dentists working in primary care in an NHS Health Board in Scotland
      was obtained. A questionnaire to assess knowledge, attitudes and clinical
      management of dry mouth patients was sent to all dentists on the NHS primary care
      service inventory. Ethical approval was obtained. RESULTS: Two hundred
      questionnaires were sent to the participants and 114 were returned, giving a
      valid response rate of 58%. Fifty percent were woman and 80% worked in the
      general dental service. Seventy-nine percent had been taught about xerostomia as 
      undergraduates but only 21% had postgraduate educational experiences of dry
      mouth. The majority correctly stated that patients with Sjogren's syndrome would 
      have an increased risk of dental caries, oral candidosis, frictional oral ulcers 
      and squamous cell carcinoma. Participants had positive attitudes with regard to
      the importance of treating dry mouth; that it was not a trivial complaint; it
      affected patients' quality of life and their general health. The dentists were
      not confident to manage dry mouth patients. Knowledge, attitudes, confidence and 
      intention to treat were affected by gender and type of primary care practice.
      Thirty-two percent of the variance of the intention to provide treatment was
      explained by working in the salaried dental service (SDS), confidence and
      attitudes regarding severity of the condition. CONCLUSIONS: Dentists working in
      the SDS had positive attitudes and increased confidence which were related to
      postgraduate educational experiences. Education at both undergraduate and
      postgraduate levels should be supported by clinical exposure to patients in order
      to improve dentists' confidence and competence to manage xerostomia and its
      complications.
FAU - Abdelghany, A
AU  - Abdelghany A
AD  - Dental Health Services Research Unit, University of Dundee, Mackenzie Building,
      Kirsty Semple Way, Dundee, DD2 4BF.
FAU - Nolan, A
AU  - Nolan A
FAU - Freeman, R
AU  - Freeman R
LA  - eng
PT  - Journal Article
DEP - 20111125
PL  - England
TA  - Br Dent J
JT  - British dental journal
JID - 7513219
SB  - IM
CIN - Br Dent J. 2011 Nov;211(10):474-5. PMID: 22116236
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Candidiasis, Oral/etiology
MH  - Carcinoma, Squamous Cell/etiology
MH  - Clinical Competence
MH  - Dental Caries/etiology
MH  - Dentist-Patient Relations
MH  - Dentists/*psychology
MH  - *Education, Dental
MH  - Female
MH  - General Practice, Dental/classification
MH  - Health Status
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mouth Neoplasms/etiology
MH  - Oral Ulcer/etiology
MH  - *Practice Patterns, Dentists'
MH  - Primary Health Care
MH  - Quality of Life
MH  - Risk Factors
MH  - Scotland
MH  - Self Concept
MH  - Sex Factors
MH  - Sjogren's Syndrome/complications
MH  - State Dentistry
MH  - Xerostomia/psychology/*therapy
MH  - Young Adult
EDAT- 2011/11/26 06:00
MHDA- 2012/04/28 06:00
CRDT- 2011/11/26 06:00
PHST- 2011/10/05 00:00 [accepted]
PHST- 2011/11/26 06:00 [entrez]
PHST- 2011/11/26 06:00 [pubmed]
PHST- 2012/04/28 06:00 [medline]
AID - sj.bdj.2011.966 [pii]
AID - 10.1038/sj.bdj.2011.966 [doi]
PST - epublish
SO  - Br Dent J. 2011 Nov 25;211(10):E21. doi: 10.1038/sj.bdj.2011.966.


PMID- 22115955
OWN - NLM
STAT- MEDLINE
DCOM- 20120726
LR  - 20151119
IS  - 1618-131X (Electronic)
IS  - 1438-4639 (Linking)
VI  - 215
IP  - 2
DP  - 2012 Feb
TI  - Human biomonitoring in the Arctic. Special challenges in a sparsely populated
      area.
PG  - 159-67
LID - 10.1016/j.ijheh.2011.10.002 [doi]
AB  - Human biomonitoring in the Arctic creates certain challenges. Important exposure 
      and health issues are: the various mixtures of contaminants found in the Arctic; 
      long-range transport sources; accumulation in the traditional food chain; unique 
      small populations; toxicant-nutrient interactions; genetic susceptibility
      factors; and multiple non-dietary confounding factors (especially lifestyle
      issues of the indigenous population groups). Through the Arctic Monitoring and
      Assessment Programme (AMAP), systematic biomonitoring studies have been
      implemented since the mid-1990 s. Some concentrations of organic contaminants and
      toxic metals in human body fluids and tissues have raised concern, leading to the
      establishment of several mother-and-child cohorts. The aim of these efforts is to
      clarify possible health effects of the contaminants, especially in relation to
      pregnancy outcome and child development. The studies are ongoing and will lead to
      improved knowledge and public health advisories to reduce the risk of adverse
      health effects for the coming generations. Some of the indigenous population
      groups of Greenland, Canada, Alaska and Russia, as well as occupationally exposed
      populations in the Russian Arctic have had special attention during the last 15
      years. The biomonitoring programs have resulted in public health interventions
      and dietary advice for vulnerable groups, like children and pregnant women. The
      sparsely populated areas where the studies are implemented create special ethical
      challenges to avoid research fatigue in the small population groups under
      surveillance. The research teams have a special responsibility to create
      communication strategies in close cooperation with the local authorities and
      build all research into a cultural context.
CI  - Copyright A(c) 2011 Elsevier GmbH. All rights reserved.
FAU - Odland, Jon Oyvind
AU  - Odland JO
AD  - Department of Community Medicine, Faculty of Health Sciences, University of
      Tromso, Norway. jon.oyvind.odland@uit.no
FAU - Nieboer, Evert
AU  - Nieboer E
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111123
PL  - Germany
TA  - Int J Hyg Environ Health
JT  - International journal of hygiene and environmental health
JID - 100898843
RN  - 0 (Biomarkers)
RN  - 0 (Hazardous Substances)
SB  - IM
MH  - Arctic Regions
MH  - Biomarkers/*analysis
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - *Environmental Exposure/adverse effects/analysis
MH  - Environmental Monitoring/*methods
MH  - Female
MH  - Food Contamination
MH  - Food Supply
MH  - *Hazardous Substances/adverse effects/analysis
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Pregnancy
MH  - Seafood
EDAT- 2011/11/26 06:00
MHDA- 2012/07/27 06:00
CRDT- 2011/11/26 06:00
PHST- 2011/03/31 00:00 [received]
PHST- 2011/09/06 00:00 [revised]
PHST- 2011/10/11 00:00 [accepted]
PHST- 2011/11/26 06:00 [entrez]
PHST- 2011/11/26 06:00 [pubmed]
PHST- 2012/07/27 06:00 [medline]
AID - S1438-4639(11)00162-3 [pii]
AID - 10.1016/j.ijheh.2011.10.002 [doi]
PST - ppublish
SO  - Int J Hyg Environ Health. 2012 Feb;215(2):159-67. doi:
      10.1016/j.ijheh.2011.10.002. Epub 2011 Nov 23.


PMID- 22115543
OWN - NLM
STAT- MEDLINE
DCOM- 20120823
LR  - 20161020
IS  - 1578-1283 (Electronic)
IS  - 0213-9111 (Linking)
VI  - 26
IP  - 2
DP  - 2012 Mar-Apr
TI  - [Ethics, equity and social determinants of health].
PG  - 178-81
LID - 10.1016/j.gaceta.2011.08.007 [doi]
AB  - The evidence shown by studies on the social determinants of health has changed
      the relationship between ethics and medicine. The evidence shown by studies on
      the social determinants of health has changed the relationship between ethics and
      medicine, and between a normative and a descriptive approach. Studies on the
      social determinants of health have also modified the traditional concept of
      equity, necessary health policies and the future of bioethics. More specifically:
      1) the boundary between medicine and ethics has become much fuzzier, especially
      in the field of epidemiology, whose objectives are now inseparable from ethical
      considerations; 2) the concept of health equity traditionally defined as access
      to healthcare should be corrected or expanded to incorporate unfair health
      inequalities that occur before patients reach the healthcare system; and 3) the
      traditional autonomy bias of bioethics should be replaced by a primary concern
      for social justice and its relationship with health.
CI  - Copyright (c) 2011 SESPAS. Published by Elsevier Espana. All rights reserved.
FAU - Puyol, Angel
AU  - Puyol A
AD  - Departamento de Filosofia, Universitat Autonoma de Barcelona, Comite de Etica
      Asistencial, Hospital Universitari Vall d'Hebron, Barcelona, Espana.
      angel.puyol@uab.cat
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
TT  - Etica, equidad y determinantes sociales de la salud.
DEP - 20111123
PL  - Spain
TA  - Gac Sanit
JT  - Gaceta sanitaria
JID - 8901623
SB  - IM
CIN - Gac Sanit. 2012 Mar-Apr;26(2):101-2. PMID: 22357063
MH  - *Bioethics
MH  - *Epidemiologic Factors
MH  - Forecasting
MH  - Health/*ethics
MH  - Health Policy
MH  - Health Priorities
MH  - Health Services Accessibility/ethics
MH  - *Healthcare Disparities
MH  - Humans
MH  - Personal Autonomy
MH  - Public Health/ethics
MH  - *Social Justice
MH  - Social Responsibility
MH  - Spain
EDAT- 2011/11/26 06:00
MHDA- 2012/08/24 06:00
CRDT- 2011/11/26 06:00
PHST- 2011/05/22 00:00 [received]
PHST- 2011/07/22 00:00 [revised]
PHST- 2011/08/25 00:00 [accepted]
PHST- 2011/11/26 06:00 [entrez]
PHST- 2011/11/26 06:00 [pubmed]
PHST- 2012/08/24 06:00 [medline]
AID - S0213-9111(11)00311-6 [pii]
AID - 10.1016/j.gaceta.2011.08.007 [doi]
PST - ppublish
SO  - Gac Sanit. 2012 Mar-Apr;26(2):178-81. doi: 10.1016/j.gaceta.2011.08.007. Epub
      2011 Nov 23.


PMID- 22115203
OWN - NLM
STAT- MEDLINE
DCOM- 20120117
LR  - 20211021
IS  - 1552-6259 (Electronic)
IS  - 0003-4975 (Linking)
VI  - 92
IP  - 6
DP  - 2011 Dec
TI  - The ethics of mechanical support: the need for new guidelines.
PG  - 1939-42
LID - 10.1016/j.athoracsur.2011.07.084 [doi]
FAU - Entwistle, John W C
AU  - Entwistle JW
AD  - Department of Cardiothoracic Surgery, Drexel University College of Medicine,
      Philadelphia, Pennsylvania 19102, USA. john.entwistle@drexelmed.edu
FAU - Sade, Robert M
AU  - Sade RM
FAU - Petrucci, Ralph J
AU  - Petrucci RJ
LA  - eng
GR  - UL1 RR029882/RR/NCRR NIH HHS/United States
GR  - UL1RR029882/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - Netherlands
TA  - Ann Thorac Surg
JT  - The Annals of thoracic surgery
JID - 15030100R
SB  - IM
MH  - Heart Failure/therapy
MH  - Heart Transplantation
MH  - Heart-Assist Devices/*ethics
MH  - Humans
MH  - *Practice Guidelines as Topic
PMC - PMC3372899
MID - NIHMS378308
EDAT- 2011/11/26 06:00
MHDA- 2012/01/18 06:00
CRDT- 2011/11/26 06:00
PHST- 2011/01/10 00:00 [received]
PHST- 2011/07/06 00:00 [revised]
PHST- 2011/07/26 00:00 [accepted]
PHST- 2011/11/26 06:00 [entrez]
PHST- 2011/11/26 06:00 [pubmed]
PHST- 2012/01/18 06:00 [medline]
AID - S0003-4975(11)01912-6 [pii]
AID - 10.1016/j.athoracsur.2011.07.084 [doi]
PST - ppublish
SO  - Ann Thorac Surg. 2011 Dec;92(6):1939-42. doi: 10.1016/j.athoracsur.2011.07.084.


PMID- 22115153
OWN - NLM
STAT- MEDLINE
DCOM- 20120404
LR  - 20111125
IS  - 1527-5418 (Electronic)
IS  - 0890-8567 (Linking)
VI  - 50
IP  - 12
DP  - 2011 Dec
TI  - Practice parameter for child and adolescent forensic evaluations.
PG  - 1299-312
LID - 10.1016/j.jaac.2011.09.020 [doi]
AB  - This Parameter addresses the key concepts that differentiate the forensic
      evaluation of children and adolescents from a clinical assessment. There are
      ethical issues unique to the forensic evaluation, because the forensic
      evaluator's duty is to the person, court, or agency requesting the evaluation,
      rather than to the patient. The forensic evaluator clarifies the legal questions 
      to be answered and structures the evaluation to address those issues. The
      forensic examination may include a review of collateral information, interviews
      and other assessments of the child or adolescent, and interviews with other
      relevant informants. The principles in this Parameter suggest the general
      approach to the forensic evaluation of children and adolescents and are relevant 
      to delinquency, child custody, child maltreatment, personal injury, and other
      court-ordered and noncourt-ordered evaluations.
CI  - Copyright (c) 2011 American Academy of Child and Adolescent Psychiatry. Published
      by Elsevier Inc. All rights reserved.
FAU - Kraus, Louis J
AU  - Kraus LJ
FAU - Thomas, Christopher R
AU  - Thomas CR
FAU - Bukstein, Oscar G
AU  - Bukstein OG
FAU - Walter, Heather J
AU  - Walter HJ
FAU - Benson, R Scott
AU  - Benson RS
FAU - Chrisman, Allan
AU  - Chrisman A
FAU - Farchione, Tiffany R
AU  - Farchione TR
FAU - Hamilton, John
AU  - Hamilton J
FAU - Keable, Helene
AU  - Keable H
FAU - Kinlan, Joan
AU  - Kinlan J
FAU - Schoettle, Ulrich
AU  - Schoettle U
FAU - Siegel, Matthew
AU  - Siegel M
FAU - Stock, Saundra
AU  - Stock S
FAU - Ptakowski, Kristin Kroeger
AU  - Ptakowski KK
FAU - Medicus, Jennifer
AU  - Medicus J
LA  - eng
PT  - Editorial
PL  - United States
TA  - J Am Acad Child Adolesc Psychiatry
JT  - Journal of the American Academy of Child and Adolescent Psychiatry
JID - 8704565
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child Abuse/*ethics/*legislation & jurisprudence/*psychology
MH  - Child Custody/*ethics/*legislation & jurisprudence
MH  - Confidentiality/legislation & jurisprudence
MH  - *Ethics, Medical
MH  - Expert Testimony/*ethics/*legislation & jurisprudence
MH  - Forensic Psychiatry/*ethics/*legislation & jurisprudence
MH  - Humans
MH  - Interview, Psychological/*methods
MH  - Juvenile Delinquency/*ethics/legislation & jurisprudence/psychology
MH  - Malpractice/*legislation & jurisprudence
MH  - Physician's Role
MH  - Psychotherapy/legislation & jurisprudence
MH  - United States
EDAT- 2011/11/26 06:00
MHDA- 2012/04/05 06:00
CRDT- 2011/11/26 06:00
PHST- 2011/08/22 00:00 [received]
PHST- 2011/09/28 00:00 [accepted]
PHST- 2011/11/26 06:00 [entrez]
PHST- 2011/11/26 06:00 [pubmed]
PHST- 2012/04/05 06:00 [medline]
AID - S0890-8567(11)00883-5 [pii]
AID - 10.1016/j.jaac.2011.09.020 [doi]
PST - ppublish
SO  - J Am Acad Child Adolesc Psychiatry. 2011 Dec;50(12):1299-312. doi:
      10.1016/j.jaac.2011.09.020.


PMID- 22115071
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20191210
IS  - 1474-4457 (Electronic)
IS  - 1473-3099 (Linking)
VI  - 11
IP  - 12
DP  - 2011 Dec
TI  - A framework for identification of infections that contribute to human obesity.
PG  - 963-9
LID - 10.1016/S1473-3099(11)70274-2 [doi]
AB  - WHO has declared obesity to be a global epidemic. Obesity management strategies
      mainly target behavioural components of the disorder, but are only marginally
      effective. A comprehensive understanding of the causative factors of obesity
      might provide more effective management approaches. Several microbes are
      causatively and correlatively linked with obesity in animals and human beings. If
      infections contribute to human obesity, then entirely different prevention and
      treatment strategies and public health policies could be needed to address this
      subtype of the disorder. Ethical reasons preclude experimental infection of human
      beings with candidate microbes to unequivocally determine their contribution to
      obesity. As an alternative, the available information about the adipogenic human 
      adenovirus Ad36 has been used to create a template that can be used to examine
      comprehensively the contributions of specific candidate microbes to human
      obesity. Clinicians should be aware of infectobesity (obesity of infectious
      origin), and its potential importance in effective obesity management.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Dhurandhar, Nikhil V
AU  - Dhurandhar NV
AD  - Infection and Obesity Laboratory, Pennington Biomedical Research Center,
      Louisiana State University System, Baton Rouge, LA 70808, USA.
      nikhil.dhurandhar@pbrc.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Lancet Infect Dis
JT  - The Lancet. Infectious diseases
JID - 101130150
SB  - IM
MH  - Adenovirus Infections, Human/complications
MH  - Adenoviruses, Human
MH  - Animals
MH  - Humans
MH  - Infections/*complications
MH  - Longitudinal Studies
MH  - Obesity/epidemiology/*microbiology
MH  - Phenotype
EDAT- 2011/11/26 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/11/26 06:00
PHST- 2011/11/26 06:00 [entrez]
PHST- 2011/11/26 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - S1473-3099(11)70274-2 [pii]
AID - 10.1016/S1473-3099(11)70274-2 [doi]
PST - ppublish
SO  - Lancet Infect Dis. 2011 Dec;11(12):963-9. doi: 10.1016/S1473-3099(11)70274-2.


PMID- 22114870
OWN - NLM
STAT- MEDLINE
DCOM- 20120626
LR  - 20211021
IS  - 1472-6874 (Electronic)
IS  - 1472-6874 (Linking)
VI  - 11
DP  - 2011 Nov 25
TI  - The facilitating factors and barriers encountered in the adoption of a humanized 
      birth care approach in a highly specialized university affiliated hospital.
PG  - 53
LID - 10.1186/1472-6874-11-53 [doi]
AB  - BACKGROUND: Considering the fact that a significant proportion of high-risk
      pregnancies are currently referred to tertiary level hospitals; and that a large 
      proportion of low obstetric risk women still seek care in these hospitals, it is 
      important to explore the factors that influence the childbirth experience in
      these hospitals, particularly, the concept of humanized birth care.The aim of
      this study was to explore the organizational and cultural factors, which act as
      barriers or facilitators in the provision of humanized obstetrical care in a
      highly specialized, university-affiliated hospital in Quebec province, in Canada.
      METHODS: A single case study design was chosen. The study sample included 17
      professionals and administrators from different disciplines, and 157 women who
      gave birth in the hospital during the study. The data was collected through
      semi-structured interviews, field notes, participant observations, a
      self-administered questionnaire, documents, and archives. Both descriptive and
      qualitative deductive content analyses were performed and ethical considerations 
      were respected. RESULTS: Both external and internal dimensions of a highly
      specialized hospital can facilitate or be a barrier to the humanization of birth 
      care practices in such institutions, whether independently, or altogether. The
      greatest facilitating factors found were: caring and family- centered model of
      care, professionals' and administrators' ambient for the provision of humanized
      birth care besides the medical interventional care which is tailored to improve
      safety, assurance, and comfort for women and their children, facilities to
      provide a pain-free birth, companionship and visiting rules, dealing with the
      patients' spiritual and religious beliefs. The most cited barriers were: the
      shortage of health care professionals, the lack of sufficient communication among
      the professionals, the stakeholders' desire for specialization rather than
      humanization, over estimation of medical performance, finally the training
      environment of the hospital leading to the presence of too many health care
      professionals, and consequently, a lack of privacy and continuity of care.
      CONCLUSION: The argument of medical intervention and technology at birth being an
      opposing factor to the humanization of birth was not seen to be an issue in the
      studied highly specialized university affiliated hospital.
FAU - Behruzi, Roxana
AU  - Behruzi R
AD  - McGill University, Faculty of Medicine, Department of Family Medicine, Montreal, 
      Canada. roksana.behruzi@mail.mcgill.ca
FAU - Hatem, Marie
AU  - Hatem M
FAU - Goulet, Lise
AU  - Goulet L
FAU - Fraser, William
AU  - Fraser W
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111125
PL  - England
TA  - BMC Womens Health
JT  - BMC women's health
JID - 101088690
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Analgesia, Obstetrical/statistics & numerical data
MH  - Canada
MH  - Communication Barriers
MH  - Culture
MH  - Family Nursing
MH  - Female
MH  - *Health Services Accessibility
MH  - *Hospitals, University
MH  - Humans
MH  - Middle Aged
MH  - *Parturition
MH  - Patient Participation
MH  - Patient-Centered Care/*standards/statistics & numerical data
MH  - Perinatal Care/organization & administration/*standards
MH  - Pregnancy
MH  - *Pregnancy, High-Risk
MH  - Religion
MH  - Surveys and Questionnaires
MH  - Young Adult
PMC - PMC3297517
EDAT- 2011/11/26 06:00
MHDA- 2012/06/27 06:00
CRDT- 2011/11/26 06:00
PHST- 2011/04/18 00:00 [received]
PHST- 2011/11/25 00:00 [accepted]
PHST- 2011/11/26 06:00 [entrez]
PHST- 2011/11/26 06:00 [pubmed]
PHST- 2012/06/27 06:00 [medline]
AID - 1472-6874-11-53 [pii]
AID - 10.1186/1472-6874-11-53 [doi]
PST - epublish
SO  - BMC Womens Health. 2011 Nov 25;11:53. doi: 10.1186/1472-6874-11-53.


PMID- 22114798
OWN - NLM
STAT- MEDLINE
DCOM- 20120413
LR  - 20111125
IS  - 1532-8228 (Electronic)
IS  - 0883-9417 (Linking)
VI  - 25
IP  - 6
DP  - 2011 Dec
TI  - Enhancing mutual accountability to promote quality, safety, and nurses' recovery 
      from substance use disorders.
PG  - 445-55
LID - 10.1016/j.apnu.2011.02.002 [doi]
AB  - Year after year, the public view nurses at the top of the list of the most honest
      and ethical professionals. However, nurses impaired with substance use disorders 
      are subject to the tremendous stigma associated with addiction. Successful
      treatment programs protect public safety and support nurses' recovery and reentry
      into practice. The purpose of this study was to explore the nurses' experience in
      an alternative-to-discipline treatment program, the Indiana State Nurses
      Assistance Program (ISNAP), administered by the Indiana State Nurses Association.
      For this study, focus groups were used to capture nurses' experience with the
      ISNAP, a nurse-monitoring program for substance use. Three focus groups were
      conducted with 25 participants. The overall theme of the focus groups was
      enhancing mutual accountability. Nurses' views were grouped into four major areas
      of importance, including accountability, clear expectations, addressing
      individual concerns, and educating others about substance use disorders. Nurses
      described how each of these factors supported and impeded their recovery. The
      findings support the need for further education and research on how to best
      promote and sustain recovery.
CI  - 2011 Elsevier Inc. All rights reserved.
FAU - Horton-Deutsch, Sara
AU  - Horton-Deutsch S
AD  - Indiana University School of Nursing, Indianapolis, IN 46202, USA.
      shortond@iupui.edu
FAU - McNelis, Angela
AU  - McNelis A
FAU - O'Haver Day, Pamela
AU  - O'Haver Day P
LA  - eng
PT  - Journal Article
DEP - 20110420
PL  - United States
TA  - Arch Psychiatr Nurs
JT  - Archives of psychiatric nursing
JID - 8708534
SB  - IM
MH  - Alcoholism/psychology/rehabilitation
MH  - Female
MH  - Focus Groups
MH  - Humans
MH  - Indiana
MH  - Male
MH  - Mental Health Services/standards
MH  - Middle Aged
MH  - *Nursing
MH  - Patient Safety
MH  - Professional Impairment/*psychology
MH  - *Social Responsibility
MH  - Substance-Related Disorders/*psychology/rehabilitation
EDAT- 2011/11/26 06:00
MHDA- 2012/04/14 06:00
CRDT- 2011/11/26 06:00
PHST- 2010/11/17 00:00 [received]
PHST- 2011/01/17 00:00 [revised]
PHST- 2011/02/03 00:00 [accepted]
PHST- 2011/11/26 06:00 [entrez]
PHST- 2011/11/26 06:00 [pubmed]
PHST- 2012/04/14 06:00 [medline]
AID - S0883-9417(11)00016-1 [pii]
AID - 10.1016/j.apnu.2011.02.002 [doi]
PST - ppublish
SO  - Arch Psychiatr Nurs. 2011 Dec;25(6):445-55. doi: 10.1016/j.apnu.2011.02.002. Epub
      2011 Apr 20.


PMID- 22114154
OWN - NLM
STAT- MEDLINE
DCOM- 20120904
LR  - 20120504
IS  - 1555-824X (Electronic)
IS  - 1062-8606 (Linking)
VI  - 27
IP  - 3
DP  - 2012 May-Jun
TI  - An ethical framework for the responsible leadership of accountable care
      organizations.
PG  - 189-94
LID - 10.1177/1062860611421226 [doi]
AB  - Using the ethical concepts of co-fiduciary responsibility in patient care and of 
      preventive ethics, this article provides an ethical framework to guide physician 
      and lay leaders of accountable care organizations. The concept of co-fiduciary
      responsibility is based on the ethical concept of medicine as a profession, which
      was introduced into the history of medical ethics in the 18th century.
      Co-fiduciary responsibility applies to everyone who influences the processes of
      patient care: physicians, organizational leaders, patients, and patients'
      surrogates. A preventive ethics approach to co-fiduciary responsibility requires 
      leaders of accountable care organizations to create organizational cultures of
      fiduciary professionalism that implement and support the following: improving
      quality based on candor and accountability, reasserting the physician's
      professional role in the informed consent process, and constraining patients' and
      surrogates' autonomy. Sustainable organizational cultures of fiduciary
      professionalism will require commitment of organizational resources and constant 
      vigilance over the intellectual and moral integrity of organizational culture.
FAU - McCullough, Laurence B
AU  - McCullough LB
AD  - Baylor College of Medicine, Houston, TX 77030-3411, USA. mccullou@bcm.edu
LA  - eng
PT  - Journal Article
DEP - 20111123
PL  - Netherlands
TA  - Am J Med Qual
JT  - American journal of medical quality : the official journal of the American
      College of Medical Quality
JID - 9300756
SB  - IM
MH  - Accountable Care Organizations/*ethics/organization & administration
MH  - *Ethics, Medical
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Leadership
MH  - Morals
MH  - Organizational Culture
MH  - *Physician's Role
MH  - Quality of Health Care/*ethics
MH  - *Social Responsibility
EDAT- 2011/11/25 06:00
MHDA- 2012/09/05 06:00
CRDT- 2011/11/25 06:00
PHST- 2011/11/25 06:00 [entrez]
PHST- 2011/11/25 06:00 [pubmed]
PHST- 2012/09/05 06:00 [medline]
AID - 1062860611421226 [pii]
AID - 10.1177/1062860611421226 [doi]
PST - ppublish
SO  - Am J Med Qual. 2012 May-Jun;27(3):189-94. doi: 10.1177/1062860611421226. Epub
      2011 Nov 23.


PMID- 22114086
OWN - NLM
STAT- MEDLINE
DCOM- 20120119
LR  - 20111124
IS  - 1471-8405 (Electronic)
IS  - 0962-7480 (Linking)
VI  - 61
IP  - 8
DP  - 2011 Dec
TI  - Individual scientific credit in occupational medicine research: ethical and
      technical issues.
PG  - 526-8
LID - 10.1093/occmed/kqr153 [doi]
FAU - Franco, Giuliano
AU  - Franco G
LA  - eng
PT  - Editorial
PL  - England
TA  - Occup Med (Lond)
JT  - Occupational medicine (Oxford, England)
JID - 9205857
SB  - IM
MH  - Authorship/standards
MH  - Biomedical Research/*ethics/*standards
MH  - *Ethics, Medical
MH  - Humans
MH  - Occupational Medicine/*ethics/*standards
EDAT- 2011/11/25 06:00
MHDA- 2012/01/20 06:00
CRDT- 2011/11/25 06:00
PHST- 2011/11/25 06:00 [entrez]
PHST- 2011/11/25 06:00 [pubmed]
PHST- 2012/01/20 06:00 [medline]
AID - kqr153 [pii]
AID - 10.1093/occmed/kqr153 [doi]
PST - ppublish
SO  - Occup Med (Lond). 2011 Dec;61(8):526-8. doi: 10.1093/occmed/kqr153.


PMID- 22113965
OWN - NLM
STAT- MEDLINE
DCOM- 20120330
LR  - 20220321
IS  - 1557-0657 (Electronic)
IS  - 1049-8931 (Linking)
VI  - 20
IP  - 4
DP  - 2011 Dec
TI  - Quality assessment of observational studies in psychiatry: an example from
      perinatal psychiatric research.
PG  - 224-34
LID - 10.1002/mpr.356 [doi]
AB  - In perinatal psychiatry, randomized controlled trials are often not feasible on
      ethical grounds. Many studies are observational in nature, while others employ
      large databases not designed primarily for research purposes. Quality assessment 
      of the resulting research is complicated by a lack of standardized tools
      specifically for this purpose. The aim of this paper is to describe the
      Systematic Assessment of Quality in Observational Research (SAQOR), a quality
      assessment tool our team devised for a series of systematic reviews and
      meta-analyses of evidence-based literature regarding risks and benefits of
      antidepressant medication during pregnancy.
CI  - Copyright (c) 2011 John Wiley & Sons, Ltd.
FAU - Ross, L E
AU  - Ross LE
AD  - Social and Epidemiological Research Department, Centre for Addiction & Mental
      Health, Toronto, ON, Canada. l.ross@utoronto.ca
FAU - Grigoriadis, S
AU  - Grigoriadis S
FAU - Mamisashvili, L
AU  - Mamisashvili L
FAU - Koren, G
AU  - Koren G
FAU - Steiner, M
AU  - Steiner M
FAU - Dennis, C-L
AU  - Dennis CL
FAU - Cheung, A
AU  - Cheung A
FAU - Mousmanis, P
AU  - Mousmanis P
LA  - eng
GR  - KRS-83127/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Methods Psychiatr Res
JT  - International journal of methods in psychiatric research
JID - 9111433
RN  - 0 (Antidepressive Agents)
SB  - IM
MH  - Antidepressive Agents/adverse effects
MH  - *Biomedical Research
MH  - Cohort Studies
MH  - Databases, Factual/statistics & numerical data
MH  - Evidence-Based Medicine
MH  - Female
MH  - Humans
MH  - Male
MH  - Mental Disorders/*diagnosis/*therapy
MH  - Observation/*methods
MH  - Outcome Assessment, Health Care
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*diagnosis
PMC - PMC6878491
EDAT- 2011/11/25 06:00
MHDA- 2012/03/31 06:00
CRDT- 2011/11/25 06:00
PHST- 2011/11/25 06:00 [entrez]
PHST- 2011/11/25 06:00 [pubmed]
PHST- 2012/03/31 06:00 [medline]
AID - 10.1002/mpr.356 [doi]
PST - ppublish
SO  - Int J Methods Psychiatr Res. 2011 Dec;20(4):224-34. doi: 10.1002/mpr.356.


PMID- 22113151
OWN - NLM
STAT- MEDLINE
DCOM- 20120518
LR  - 20220410
IS  - 1872-6054 (Electronic)
IS  - 0168-8510 (Linking)
VI  - 104
IP  - 2
DP  - 2012 Feb
TI  - Nudge: a new and better way to improve health?
PG  - 200-3
LID - 10.1016/j.healthpol.2011.10.013 [doi]
AB  - Nudging, or libertarian paternalism, is presented as a new and ethically
      justified way of improving people's health. It has proved influential and is
      currently taken up by the governments in the US, the UK and France. One may
      question the claim that the approach is new, in any case it has many similarities
      with the idea of "making healthy choices easier". Whether the approach is better 
      from an ethical perspective depends on the ethical principles one holds. From a
      paternalistic perspective there could be no objections, but from a libertarian,
      there are several. Contrary to what the authors state, libertarian paternalism is
      an oxymoron.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Vallgarda, Signild
AU  - Vallgarda S
AD  - Unit of Health Services Research, Department of Public Health, University of
      Copenhagen, Denmark. siva@sund.ku.dk
LA  - eng
PT  - Journal Article
DEP - 20111121
PL  - Ireland
TA  - Health Policy
JT  - Health policy (Amsterdam, Netherlands)
JID - 8409431
MH  - Choice Behavior
MH  - Freedom
MH  - Health Behavior
MH  - *Health Promotion/legislation & jurisprudence/methods
MH  - *Health Status
MH  - Humans
MH  - Paternalism
EDAT- 2011/11/25 06:00
MHDA- 2012/05/19 06:00
CRDT- 2011/11/25 06:00
PHST- 2011/05/31 00:00 [received]
PHST- 2011/10/21 00:00 [revised]
PHST- 2011/10/25 00:00 [accepted]
PHST- 2011/11/25 06:00 [entrez]
PHST- 2011/11/25 06:00 [pubmed]
PHST- 2012/05/19 06:00 [medline]
AID - S0168-8510(11)00240-5 [pii]
AID - 10.1016/j.healthpol.2011.10.013 [doi]
PST - ppublish
SO  - Health Policy. 2012 Feb;104(2):200-3. doi: 10.1016/j.healthpol.2011.10.013. Epub 
      2011 Nov 21.


PMID- 22113102
OWN - NLM
STAT- MEDLINE
DCOM- 20120309
LR  - 20220317
IS  - 1879-1409 (Electronic)
IS  - 0305-4179 (Linking)
VI  - 38
IP  - 1
DP  - 2012 Feb
TI  - Fibrinogen function after severe burn injury.
PG  - 77-82
LID - 10.1016/j.burns.2010.12.004 [doi]
AB  - BACKGROUND: Evidence regarding hypercoagulability in the first week after burn
      trauma is growing. This hypercoagulable state may partly be caused by increased
      fibrinogen levels. Rotational thrombelastometry offers a test which measures
      functional fibrinogen (FIBTEM((R))). To test the hypothesis that in patients with
      severe burn injury fibrinogen function changes over time, we simultaneously
      measured FIBTEM((R)) and fibrinogen concentration early after burn trauma.
      METHODS: After Ethics Committee approval consecutive patients with severe burn
      trauma admitted to the burn intensive care unit of the General Hospital of Vienna
      were included in the study. Blood examinations were done immediately and 12, 24
      and 48 h after admission. At each time point fibrinogen level (Clauss) and 4
      commercially available ROTEM((R)) tests were performed. RESULTS: 20 consecutive
      patients were included in the study. Fibrinogen level and FIBTEM((R)) MCF were
      within the reference range until 24 h after burn trauma but increased
      significantly 48 h after trauma. There was a significant correlation between
      FIBTEM((R)) MCF and fibrinogen level (R=0.714, p<0.001). CONCLUSION: The results 
      of this prospective observational clinical study show that fibrinogen function
      changes early after burn trauma and can be visualized by ROTEM((R)) with the
      fibrinogen-sensitive FIBTEM((R)) test.
CI  - Copyright (c) 2010 Elsevier Ltd and ISBI. All rights reserved.
FAU - Schaden, Eva
AU  - Schaden E
AD  - Dept. of Anesthesiology, General Intensive Care and Pain Control, Medical
      University Of Vienna, Austria. eva.schaden@meduniwien.ac.at
FAU - Hoerburger, David
AU  - Hoerburger D
FAU - Hacker, Stefan
AU  - Hacker S
FAU - Kraincuk, Paul
AU  - Kraincuk P
FAU - Baron, David M
AU  - Baron DM
FAU - Kozek-Langenecker, Sibylle
AU  - Kozek-Langenecker S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111123
PL  - Netherlands
TA  - Burns
JT  - Burns : journal of the International Society for Burn Injuries
JID - 8913178
RN  - 9001-32-5 (Fibrinogen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Coagulation/physiology
MH  - Blood Coagulation Tests
MH  - Burns/*blood
MH  - Female
MH  - Fibrinogen/analysis/*physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Thrombelastography
EDAT- 2011/11/25 06:00
MHDA- 2012/03/10 06:00
CRDT- 2011/11/25 06:00
PHST- 2010/08/03 00:00 [received]
PHST- 2010/11/14 00:00 [revised]
PHST- 2010/12/05 00:00 [accepted]
PHST- 2011/11/25 06:00 [entrez]
PHST- 2011/11/25 06:00 [pubmed]
PHST- 2012/03/10 06:00 [medline]
AID - S0305-4179(10)00323-2 [pii]
AID - 10.1016/j.burns.2010.12.004 [doi]
PST - ppublish
SO  - Burns. 2012 Feb;38(1):77-82. doi: 10.1016/j.burns.2010.12.004. Epub 2011 Nov 23.


PMID- 22112799
OWN - NLM
STAT- MEDLINE
DCOM- 20120418
LR  - 20211021
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 12
DP  - 2011 Nov 23
TI  - Five years of Trials.
PG  - 248
LID - 10.1186/1745-6215-12-248 [doi]
AB  - This editorial marks the launch of a special collection of articles highlighting 
      'Five years of Trials' (http://www.trialsjournal.com/series/5years). The
      journal's achievements on its objectives since 2006 are described and some of the
      challenges still ahead are outlined - in particular further innovating in the
      reporting of trials and the publication of negative results. The other articles
      in this series are examples of where Trials has demonstrated progress on its
      objectives. These include the publication of raw data, extended versions of
      previously published trial-related articles, descriptions of 'lessons learned',
      negative results, and educational articles regarding ethics and reporting bias.
FAU - Altman, Douglas G
AU  - Altman DG
FAU - Hrynaszkiewicz, Iain
AU  - Hrynaszkiewicz I
FAU - Furberg, Curt D
AU  - Furberg CD
FAU - Grimshaw, Jeremy M
AU  - Grimshaw JM
FAU - Rothwell, Peter M
AU  - Rothwell PM
LA  - eng
PT  - Editorial
DEP - 20111123
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
SB  - IM
MH  - Clinical Protocols
MH  - *Clinical Trials as Topic
MH  - Humans
MH  - Publications
PMC - PMC3254076
EDAT- 2011/11/25 06:00
MHDA- 2012/04/19 06:00
CRDT- 2011/11/25 06:00
PHST- 2011/11/21 00:00 [received]
PHST- 2011/11/23 00:00 [accepted]
PHST- 2011/11/25 06:00 [entrez]
PHST- 2011/11/25 06:00 [pubmed]
PHST- 2012/04/19 06:00 [medline]
AID - 1745-6215-12-248 [pii]
AID - 10.1186/1745-6215-12-248 [doi]
PST - epublish
SO  - Trials. 2011 Nov 23;12:248. doi: 10.1186/1745-6215-12-248.


PMID- 22112781
OWN - NLM
STAT- MEDLINE
DCOM- 20120427
LR  - 20181201
IS  - 1879-0887 (Electronic)
IS  - 0167-8140 (Linking)
VI  - 102
IP  - 1
DP  - 2012 Jan
TI  - Concomitant intensity modulated boost during whole breast hypofractionated
      radiotherapy--a feasibility and toxicity study.
PG  - 89-95
LID - 10.1016/j.radonc.2011.10.015 [doi]
AB  - BACKGROUND: Breast cancer sensitivity to large fraction size may be enhanced
      using hypofractionated concomitant boost radiotherapy (CBRT), thereby shortening 
      overall treatment time. This ethics approved, prospective single cohort
      feasibility study was designed to evaluate the dosimetry and toxicity of CBRT
      using an intensity-modulated radiotherapy (IMRT) technique, compared with a
      standard sequential boost technique (SBT). METHODS: Fifteen women (11
      right-sided; 4 left-sided) received 42.4 Gy to the whole breast and an additional
      10.08 Gy to the tumor bed in 16 daily fractions, using IMRT and standard dose
      constraints. Each patient was replanned with the SBT, using mixed
      photon-electrons. Clinical target volume (CTV), dose evaluation volume (DEV), and
      organs at risk (OAR) dose distributions were compared with the SBT. Toxicity and 
      treatment times were prospectively recorded. RESULTS: All 15 CBRT plans achieved 
      the desired CTV (V(49.9Gy) >/= 99%) and DEV (V(49.9Gy) >/= 95%), coverage of the 
      boost, compared with only 10 (66.7%, p=0.03), and 12 (80%, p=0.125) SBT plans,
      respectively. Ipsilateral lung (p<0.0001), and heart (right-sided, p=0.001;
      left-sided, p=0.13) doses were lower. Grade 3 acute toxicity occurred in 1 (6.7%)
      patient. At 1 year, two (13.3%) additional patients had overall grade 2 late
      toxicity, compared with baseline. No grade 3-4 late toxicity was observed.
      CONCLUSIONS: CBRT using IMRT improved boost coverage and lowered OAR doses,
      compared with SBT. Toxicities were acceptable using a daily boost of 3.28 Gy.
      While resource utilization was greater, overall treatment time was reduced.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Teh, Amy Yuen Meei
AU  - Teh AY
AD  - Radiation Medicine Program, Princess Margaret Hospital, University Health
      Network, Toronto, Ontario, Canada.
FAU - Walsh, Lorraine
AU  - Walsh L
FAU - Purdie, Thomas G
AU  - Purdie TG
FAU - Mosseri, Allen
AU  - Mosseri A
FAU - Xu, Wei
AU  - Xu W
FAU - Levin, Wilfred
AU  - Levin W
FAU - Koch, C Anne
AU  - Koch CA
FAU - Fyles, Anthony
AU  - Fyles A
FAU - Liu, Fei-Fei
AU  - Liu FF
FAU - Cho, B C John
AU  - Cho BC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111121
PL  - Ireland
TA  - Radiother Oncol
JT  - Radiotherapy and oncology : journal of the European Society for Therapeutic
      Radiology and Oncology
JID - 8407192
SB  - IM
MH  - Breast Neoplasms/*radiotherapy/surgery
MH  - Dose Fractionation, Radiation
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Prospective Studies
MH  - Radiotherapy Dosage
MH  - Radiotherapy, Intensity-Modulated/adverse effects/*methods
MH  - Statistics, Nonparametric
MH  - Treatment Outcome
EDAT- 2011/11/25 06:00
MHDA- 2012/04/28 06:00
CRDT- 2011/11/25 06:00
PHST- 2011/05/16 00:00 [received]
PHST- 2011/10/18 00:00 [revised]
PHST- 2011/10/20 00:00 [accepted]
PHST- 2011/11/25 06:00 [entrez]
PHST- 2011/11/25 06:00 [pubmed]
PHST- 2012/04/28 06:00 [medline]
AID - S0167-8140(11)00627-X [pii]
AID - 10.1016/j.radonc.2011.10.015 [doi]
PST - ppublish
SO  - Radiother Oncol. 2012 Jan;102(1):89-95. doi: 10.1016/j.radonc.2011.10.015. Epub
      2011 Nov 21.


PMID- 22112694
OWN - NLM
STAT- MEDLINE
DCOM- 20120426
LR  - 20220330
IS  - 1749-8090 (Electronic)
IS  - 1749-8090 (Linking)
VI  - 6
DP  - 2011 Nov 23
TI  - Prolonged ventilation post cardiac surgery--tips and pitfalls of the prediction
      game.
PG  - 158
LID - 10.1186/1749-8090-6-158 [doi]
AB  - BACKGROUND: Few available models aim to identify patients at risk of prolonged
      ventilation after cardiac surgery. We compared prediction models developed in ICU
      in two adjacent periods of time, when significant changes were observed both in
      population characteristics and the perioperative management. METHODS: We
      performed a retrospective review of two cohorts of patients in our department in 
      two subsequent time periods (July 2007 - December 2008, n = 2165; January 2009 - 
      July 2010, n = 2192). The study was approved by the Institutional Ethics
      Committee and the individual patient consent was not required. Patients were
      divided with regard to ventilation time of more or less than 48 hours.
      Preoperative and procedure-related variables for prolonged ventilation were
      identified and multivariate logistic regression analysis was performed separately
      for each cohort. RESULTS: Most recent patients were older, with more
      co-morbidities, more frequently undergoing off-pump surgery. At the beginning of 
      2009 we also changed the technique of postoperative ventilation. Percentage of
      patients with prolonged ventilation decreased from 5.7% to 2.4% (p < 0.0001).
      Preoperative and procedure-related variables for prolonged ventilation were
      identified. Prediction models for prolonged ventilation were different for each
      cohort. Most recent significant predictors were: aortic aneurysm surgery (OR
      12.9), emergency surgery (OR 5.3), combined procedures (OR 5.1), valve procedures
      (OR 3.2), preoperative renal dysfunction (OR 2.9) and preoperative stroke or TIA 
      (OR 2.8). CONCLUSIONS: Prediction models for postoperative ventilation should be 
      regularly updated, particularly when major changes are noted in patients'
      demographics and surgical or anaesthetic technique.
CI  - (c) 2011 Knapik et al; licensee BioMed Central Ltd.
FAU - Knapik, Piotr
AU  - Knapik P
AD  - Department of Cardiac Anaesthesia and Intensive Care, Silesian Centre for Heart
      Diseases, Zabrze, Poland. pknapik@sum.edu.pl
FAU - Ciesla, Daniel
AU  - Ciesla D
FAU - Borowik, Dawid
AU  - Borowik D
FAU - Czempik, Piotr
AU  - Czempik P
FAU - Knapik, Tomasz
AU  - Knapik T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20111123
PL  - England
TA  - J Cardiothorac Surg
JT  - Journal of cardiothoracic surgery
JID - 101265113
SB  - IM
MH  - Aged
MH  - *Cardiac Surgical Procedures
MH  - Follow-Up Studies
MH  - Heart Diseases/surgery
MH  - Humans
MH  - Intensive Care Units
MH  - Male
MH  - Postoperative Care/*methods
MH  - *Practice Guidelines as Topic
MH  - Prognosis
MH  - Respiration, Artificial/methods/*standards
MH  - Retrospective Studies
MH  - Time Factors
PMC - PMC3248367
EDAT- 2011/11/25 06:00
MHDA- 2012/04/27 06:00
CRDT- 2011/11/25 06:00
PHST- 2011/07/11 00:00 [received]
PHST- 2011/11/23 00:00 [accepted]
PHST- 2011/11/25 06:00 [entrez]
PHST- 2011/11/25 06:00 [pubmed]
PHST- 2012/04/27 06:00 [medline]
AID - 1749-8090-6-158 [pii]
AID - 10.1186/1749-8090-6-158 [doi]
PST - epublish
SO  - J Cardiothorac Surg. 2011 Nov 23;6:158. doi: 10.1186/1749-8090-6-158.


PMID- 22112388
OWN - NLM
STAT- MEDLINE
DCOM- 20120502
LR  - 20211021
IS  - 1878-4380 (Electronic)
IS  - 0966-842X (Linking)
VI  - 20
IP  - 1
DP  - 2012 Jan
TI  - The Human Microbiome Project: lessons from human genomics.
PG  - 1-4
LID - 10.1016/j.tim.2011.10.004 [doi]
AB  - The Human Microbiome Project (HMP) is following in the footsteps of the Human
      Genome Project (HGP), which will include exciting discoveries, but also potential
      disappointment and resentment over the lack of medical applications. There is a
      wiser path for the HMP. This path includes a greater attention to rare variation,
      an early commitment to an ethical inclusion of indigenous communities, and a
      recruitment strategy in which medical benefits are de-emphasized.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Lewis, Cecil M Jr
AU  - Lewis CM Jr
AD  - Department of Anthropology, University of Oklahoma, Norman, Oklahoma, USA.
      cmlewis@ou.edu
FAU - Obregon-Tito, Alexandra
AU  - Obregon-Tito A
FAU - Tito, Raul Y
AU  - Tito RY
FAU - Foster, Morris W
AU  - Foster MW
FAU - Spicer, Paul G
AU  - Spicer PG
LA  - eng
GR  - R01 GM089886/GM/NIGMS NIH HHS/United States
GR  - R01 HG005172/HG/NHGRI NIH HHS/United States
GR  - R01 HG005172-01/HG/NHGRI NIH HHS/United States
GR  - R01 GM089886-01A1/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20111121
PL  - England
TA  - Trends Microbiol
JT  - Trends in microbiology
JID - 9310916
SB  - IM
MH  - Genomics/*methods/trends
MH  - Humans
MH  - Medicine/methods/trends
MH  - *Metagenome
PMC - PMC3709440
MID - NIHMS487149
EDAT- 2011/11/25 06:00
MHDA- 2012/05/04 06:00
CRDT- 2011/11/25 06:00
PHST- 2011/08/31 00:00 [received]
PHST- 2011/10/17 00:00 [revised]
PHST- 2011/10/25 00:00 [accepted]
PHST- 2011/11/25 06:00 [entrez]
PHST- 2011/11/25 06:00 [pubmed]
PHST- 2012/05/04 06:00 [medline]
AID - S0966-842X(11)00193-4 [pii]
AID - 10.1016/j.tim.2011.10.004 [doi]
PST - ppublish
SO  - Trends Microbiol. 2012 Jan;20(1):1-4. doi: 10.1016/j.tim.2011.10.004. Epub 2011
      Nov 21.


PMID- 22111658
OWN - NLM
STAT- MEDLINE
DCOM- 20120615
LR  - 20211021
IS  - 1471-230X (Electronic)
IS  - 1471-230X (Linking)
VI  - 11
DP  - 2011 Nov 23
TI  - A randomized double-blind placebo-controlled trial to evaluate the value of a
      single bolus intravenous alfentanil in CT colonography.
PG  - 128
LID - 10.1186/1471-230X-11-128 [doi]
AB  - BACKGROUND: Although CT colonography is a less invasive alternative for
      colonoscopy for the detection of colorectal polyps and cancer, procedural pain is
      common. In several studies, CT colonography pain and burden is higher than in
      colonoscopy. Apart from discomfort, anxiety and its related stress-induced peri- 
      procedural side effects, this may influence the adherence for CT colonography as 
      a possible screening tool for colorectal cancer. We hypothesize that a single
      bolus intravenous alfentanil will give a clinically relevant reduction in maximum
      pain defined as at least 1.3 point reduction on an 11-point numeric rating scale 
      (NRS). METHODS/DESIGN: A randomized double-blind placebo-controlled trial in
      which patients scheduled for elective CT colonography in a single tertiary centre
      are eligible for inclusion. The first 90 consenting patient will be
      block-randomized to either the alfentanil group or the placebo group. Before
      bowel insufflation, the alfentanil group receives a single bolus intravenous
      alfentanil 7.5 mug/kg dissolved in 0.9% NaCl, while the placebo group receives an
      intravenous bolus injection of pure 0.9% NaCl. For both groups an equal amount of
      fluid per kilogram (75 muL/kg) is injected. The primary outcome is the difference
      in maximum pain on an 11-point NRS. Secondary outcomes include: pain and burden
      of different CT colonography aspects, side effects, procedural time and recovery 
      time. For the primary outcome an independent samples t-test is performed and a P 
      value<0.05 is considered statistically significant. DISCUSSION: This study will
      provide evidence whether a single bolus intravenous alfentanil gives a clinically
      relevant reduction in maximum pain during CT colonography. TRIAL REGISTRATION:
      Netherlands Trial Register (NTR): NTR2902. This trial will be conducted in
      accordance with the protocol and in compliance with the moral, ethical, and
      scientific principles governing clinical research as set out in the Declaration
      of Helsinki (1989) and Good Clinical Practice (GCP). The department of radiology 
      of the Academic Medical Center of Amsterdam is responsible for the design and
      conduct of the trial.
FAU - Boellaard, Thierry N
AU  - Boellaard TN
AD  - Department of Radiology, Academic Medical Center, University of Amsterdam, the
      Netherlands. t.n.boellaard@amc.uva.nl
FAU - van der Paardt, Marije P
AU  - van der Paardt MP
FAU - Eberl, Susanne
AU  - Eberl S
FAU - Hollmann, Markus W
AU  - Hollmann MW
FAU - Stoker, Jaap
AU  - Stoker J
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20111123
PL  - England
TA  - BMC Gastroenterol
JT  - BMC gastroenterology
JID - 100968547
RN  - 0 (Analgesics, Opioid)
RN  - 1N74HM2BS7 (Alfentanil)
SB  - IM
MH  - Abdominal Pain/etiology/*prevention & control
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alfentanil/*administration & dosage
MH  - Analgesics, Opioid/*administration & dosage
MH  - Colonic Polyps/diagnostic imaging
MH  - Colonography, Computed Tomographic/*adverse effects
MH  - Colorectal Neoplasms/*diagnostic imaging
MH  - Double-Blind Method
MH  - Humans
MH  - Injections, Intravenous
MH  - Insufflation/adverse effects
MH  - Middle Aged
MH  - Pain Measurement
MH  - Patient Satisfaction
MH  - Surveys and Questionnaires
MH  - Time Factors
MH  - Young Adult
PMC - PMC3339326
EDAT- 2011/11/25 06:00
MHDA- 2012/06/16 06:00
CRDT- 2011/11/25 06:00
PHST- 2011/06/09 00:00 [received]
PHST- 2011/11/23 00:00 [accepted]
PHST- 2011/11/25 06:00 [entrez]
PHST- 2011/11/25 06:00 [pubmed]
PHST- 2012/06/16 06:00 [medline]
AID - 1471-230X-11-128 [pii]
AID - 10.1186/1471-230X-11-128 [doi]
PST - epublish
SO  - BMC Gastroenterol. 2011 Nov 23;11:128. doi: 10.1186/1471-230X-11-128.


PMID- 22111423
OWN - NLM
STAT- MEDLINE
DCOM- 20111220
LR  - 20111124
IS  - 0040-7453 (Print)
IS  - 0040-7453 (Linking)
VI  - 136
IP  - 8
DP  - 2011 Aug
TI  - [Brain teaser for the ethics committee].
PG  - 586-7
FAU - van Herten, Joost
AU  - van Herten J
LA  - dut
PT  - Journal Article
TT  - Hoofdbrekers voor de commissie ethiek.
PL  - Netherlands
TA  - Tijdschr Diergeneeskd
JT  - Tijdschrift voor diergeneeskunde
JID - 0031550
SB  - IM
MH  - Animal Welfare
MH  - Animals
MH  - Breeding/*methods
MH  - Dogs/*physiology
MH  - Female
MH  - Insemination, Artificial/ethics/*veterinary
MH  - Pregnancy
MH  - Veterinary Medicine/*ethics
EDAT- 2011/11/25 06:00
MHDA- 2011/12/21 06:00
CRDT- 2011/11/25 06:00
PHST- 2011/11/25 06:00 [entrez]
PHST- 2011/11/25 06:00 [pubmed]
PHST- 2011/12/21 06:00 [medline]
PST - ppublish
SO  - Tijdschr Diergeneeskd. 2011 Aug;136(8):586-7.


PMID- 22111224
OWN - NLM
STAT- MEDLINE
DCOM- 20111213
LR  - 20111124
IS  - 0023-7205 (Print)
IS  - 0023-7205 (Linking)
VI  - 108
IP  - 39
DP  - 2011 Sep 28-Oct 4
TI  - [Ethics, health and money. Philanthropic big companies scrutinized in USA].
PG  - 1885
FAU - Jeppsson, Anders
AU  - Jeppsson A
AD  - andjep@gmail.com
LA  - swe
PT  - Journal Article
TT  - Etik, halsa och pengar. Filantropiska storforetag granskas i USA.
PL  - Sweden
TA  - Lakartidningen
JT  - Lakartidningen
JID - 0027707
SB  - IM
MH  - *Fund Raising/economics/ethics
MH  - Humans
MH  - *Occupational Health
MH  - Research Support as Topic/economics/ethics
MH  - United States
EDAT- 2011/11/25 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/11/25 06:00
PHST- 2011/11/25 06:00 [entrez]
PHST- 2011/11/25 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
PST - ppublish
SO  - Lakartidningen. 2011 Sep 28-Oct 4;108(39):1885.


PMID- 22111050
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111123
LR  - 20211021
IS  - 2233-7393 (Electronic)
IS  - 2233-7393 (Linking)
VI  - 47
IP  - 1
DP  - 2011 Apr
TI  - Tissue engineering: current strategies and future directions.
PG  - 1-13
LID - 10.4068/cmj.2011.47.1.1 [doi]
AB  - Novel therapies resulting from regenerative medicine and tissue engineering
      technology may offer new hope for patients with injuries, end-stage organ
      failure, or other clinical issues. Currently, patients with diseased and injured 
      organs are often treated with transplanted organs. However, there is a shortage
      of donor organs that is worsening yearly as the population ages and as the number
      of new cases of organ failure increases. Scientists in the field of regenerative 
      medicine and tissue engineering are now applying the principles of cell
      transplantation, material science, and bioengineering to construct biological
      substitutes that can restore and maintain normal function in diseased and injured
      tissues. In addition, the stem cell field is a rapidly advancing part of
      regenerative medicine, and new discoveries in this field create new options for
      this type of therapy. For example, new types of stem cells, such as amniotic
      fluid and placental stem cells that can circumvent the ethical issues associated 
      with embryonic stem cells, have been discovered. The process of therapeutic
      cloning and the creation of induced pluripotent cells provide still other
      potential sources of stem cells for cell-based tissue engineering applications.
      Although stem cells are still in the research phase, some therapies arising from 
      tissue engineering endeavors that make use of autologous, adult cells have
      already entered the clinical setting, indicating that regenerative medicine holds
      much promise for the future.
FAU - Olson, Jennifer L
AU  - Olson JL
AD  - Wake Forest Institute for Regenerative Medicine, Wake Forest University School of
      Medicine, NC, USA.
FAU - Atala, Anthony
AU  - Atala A
FAU - Yoo, James J
AU  - Yoo JJ
LA  - eng
PT  - Journal Article
DEP - 20110426
PL  - Korea (South)
TA  - Chonnam Med J
JT  - Chonnam medical journal
JID - 101564659
PMC - PMC3214857
OTO - NOTNLM
OT  - Biomaterials
OT  - Cell transplantation
OT  - Regenerative medicine
OT  - Stem cell
OT  - Tissue engineering
EDAT- 2011/11/24 06:00
MHDA- 2011/11/24 06:01
CRDT- 2011/11/24 06:00
PHST- 2011/03/31 00:00 [received]
PHST- 2011/04/08 00:00 [accepted]
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/11/24 06:01 [medline]
AID - 10.4068/cmj.2011.47.1.1 [doi]
PST - ppublish
SO  - Chonnam Med J. 2011 Apr;47(1):1-13. doi: 10.4068/cmj.2011.47.1.1. Epub 2011 Apr
      26.


PMID- 22109908
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1868-6001 (Electronic)
IS  - 1868-310X (Linking)
VI  - 3
IP  - 2
DP  - 2012 Apr
TI  - Genetic screening and democracy: lessons from debating genetic screening criteria
      in the Netherlands.
PG  - 79-89
LID - 10.1007/s12687-011-0063-z [doi]
AB  - Recent decades have witnessed increasing possibilities for genetic testing and
      screening. In clinical genetics, the doctor's office defined a secluded space for
      discussion of sensitive reproductive options in cases of elevated risk for
      genetic disorders in individuals or their offspring. When prenatal screening for 
      all pregnant women became conceivable, the potential increase in scale made
      social and ethical concerns relevant for the whole of society. Whereas genetic
      testing in clinical genetic practice was widely accepted, prenatal screening at a
      population level met with unease. Concerns were raised regarding social pressure 
      to screen: the sum of individual choice might result in a 'collective eugenics'. 
      The government's involvement also raised suspicion: actively offering screening
      evoked associations with eugenic population policies from the first half of the
      20th century. By reconstructing elements of policy and public debate on prenatal 
      screening in the Netherlands from the past 30 years, this article discusses how
      the government has gradually changed its role in balancing the interest of the
      individual and the collective on genetic reproductive issues. Against a
      background of increasing knowledge about and demand for prenatal screening among 
      the population, governmental policy changed from focusing on protection by
      banning screening toward facilitating screening in a careful and ethically sound 
      way by providing adequate information, decision aids and quality assessment
      instruments. In the meanwhile, invigorating democracy in public debate may entail
      discussing concepts of 'the good life' in relation to living with or without
      impairments and dealing with genetic information about oneself or one's
      offspring.
FAU - van El, Carla Geertruida
AU  - van El CG
AD  - Section Community Genetics, Department of Clinical Genetics and EMGO Institute
      for Health and Care Research, VU University Medical Center, Van der
      Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands, cg.vanel@vumc.nl.
FAU - Pieters, Toine
AU  - Pieters T
FAU - Cornel, Martina
AU  - Cornel M
LA  - eng
PT  - Journal Article
DEP - 20110830
PL  - Germany
TA  - J Community Genet
JT  - Journal of community genetics
JID - 101551501
PMC - PMC3312946
EDAT- 2011/11/24 06:00
MHDA- 2011/11/24 06:01
CRDT- 2011/11/24 06:00
PHST- 2011/05/20 00:00 [received]
PHST- 2011/08/05 00:00 [accepted]
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/11/24 06:01 [medline]
AID - 10.1007/s12687-011-0063-z [doi]
PST - ppublish
SO  - J Community Genet. 2012 Apr;3(2):79-89. doi: 10.1007/s12687-011-0063-z. Epub 2011
      Aug 30.


PMID- 22109907
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1868-6001 (Electronic)
IS  - 1868-310X (Linking)
VI  - 3
IP  - 2
DP  - 2012 Apr
TI  - Is there a doctor in the house? : The presence of physicians in the
      direct-to-consumer genetic testing context.
PG  - 105-12
LID - 10.1007/s12687-011-0062-0 [doi]
AB  - Over the last couple of years, many commercial companies, the majority of which
      are based in the USA, have been advertising and offering direct-to-consumer (DTC)
      genetic testing services outside of the established health care system, and often
      without any involvement from a health care professional. In the last year,
      however, a number of DTC genetic testing companies have changed their provision
      model such that consumers must now contact a health care professional before
      being able to order the genetic testing service. In discussing the advent of this
      new model of service provision, this article also reviews the ethical and social 
      issues surrounding DTC genetic testing and addresses the potential motivations
      for change, some barriers to achieving truly appropriate medical supervision and 
      the present reality of DTC genetic testing for some psychiatric and neurological 
      disorders. Since the advent of these commercial activities, critics have pointed 
      a finger at the lack of medical supervision surrounding these services. The
      discussion herein, however, reveals how difficult it may be, despite the addition
      of a physician, to actually achieve adequate medical supervision within the
      present context of DTC genetic testing.
FAU - Howard, Heidi Carmen
AU  - Howard HC
AD  - Centre for Biomedical Ethics and Law, Katholieke Universiteit Leuven,
      Kapucijnenvoer 35, Box 7001, 3000, Leuven, Belgium, heidi.howard@med.kuleuven.be.
FAU - Borry, Pascal
AU  - Borry P
LA  - eng
PT  - Journal Article
DEP - 20110906
PL  - Germany
TA  - J Community Genet
JT  - Journal of community genetics
JID - 101551501
PMC - PMC3312941
EDAT- 2011/11/24 06:00
MHDA- 2011/11/24 06:01
CRDT- 2011/11/24 06:00
PHST- 2011/04/29 00:00 [received]
PHST- 2011/08/05 00:00 [accepted]
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/11/24 06:01 [medline]
AID - 10.1007/s12687-011-0062-0 [doi]
PST - ppublish
SO  - J Community Genet. 2012 Apr;3(2):105-12. doi: 10.1007/s12687-011-0062-0. Epub
      2011 Sep 6.


PMID- 22109905
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1868-6001 (Electronic)
IS  - 1868-310X (Linking)
VI  - 3
IP  - 2
DP  - 2012 Apr
TI  - The promises of genomic screening: building a governance infrastructure. Special 
      issue: genetics and democracy.
PG  - 73-7
LID - 10.1007/s12687-011-0056-y [doi]
AB  - New screening possibilities become available at a high rate, both useful and
      unsound possibilities. All screening programmes do harm, and only few have more
      advantages than disadvantages at reasonable cost. Horizon scanning is needed to
      identify those few possibilities with more pros than cons. Attunement is needed
      between actors involved: scientists developing new high-throughput screening
      techniques and treatment, health care workers, patients and consumers and
      governmental agencies. The product of a process of attunement may be a quality
      mark as a norm for professional conduct, rather than legal measures, as the field
      is moving fast. As actors may have varying perspectives, a governance structure
      is needed to develop an agenda that is agreed upon by all or most actors
      involved. A standing committee might oversee the evaluation of benefits and
      disadvantages in an integrated approach, taking evidence, economics and ethics
      into account. A proactive role of governmental agencies is needed to facilitate
      agenda setting and attunement. Policy making has to be transparent and open to
      stakeholder engagement.
FAU - Cornel, Martina C
AU  - Cornel MC
AD  - Section Community Genetics, Department of Clinical Genetics and EMGO Institute
      for Health and Care Research, VU University Medical Center, BS7, D423, PO Box
      7057, 1007 MB, Amsterdam, The Netherlands, mc.cornel@vumc.nl.
FAU - van El, Carla G
AU  - van El CG
FAU - Dondorp, Wybo J
AU  - Dondorp WJ
LA  - eng
PT  - Journal Article
DEP - 20110707
PL  - Germany
TA  - J Community Genet
JT  - Journal of community genetics
JID - 101551501
PMC - PMC3312944
EDAT- 2011/11/24 06:00
MHDA- 2011/11/24 06:01
CRDT- 2011/11/24 06:00
PHST- 2011/03/30 00:00 [received]
PHST- 2011/06/23 00:00 [accepted]
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/11/24 06:01 [medline]
AID - 10.1007/s12687-011-0056-y [doi]
PST - ppublish
SO  - J Community Genet. 2012 Apr;3(2):73-7. doi: 10.1007/s12687-011-0056-y. Epub 2011 
      Jul 7.


PMID- 22109772
OWN - NLM
STAT- MEDLINE
DCOM- 20120517
LR  - 20211021
IS  - 1567-2387 (Electronic)
IS  - 1567-2379 (Linking)
VI  - 43
IP  - 1
DP  - 2012 Feb
TI  - Cytogenetic instability of dental pulp stem cell lines.
PG  - 89-94
LID - 10.1007/s10735-011-9373-z [doi]
AB  - Human adult stem cells (hASCs) offer a potentially renewable source of cell types
      that are easily isolated and rapidly expanded for use in regenerative medicine
      and cell therapies without the complicating ethical problems that are associated 
      with embryonic stem cells. However, the eventual therapeutic use of hASCs
      requires that these cells and their derivatives maintain their genomic stability.
      There is currently a lack of systematic studies that are aimed at characterising 
      aberrant chromosomal changes in cultured ASCs over time. However, the presence of
      mosaicism and accumulation of karyotypic abnormalities within cultured cell
      subpopulations have been reported. To investigate cytogenetic integrity of
      cultured human dental stem cell (hDSC) lines, we analysed four expanded hDSC
      cultures using classical G banding and fluorescent in situ hybridisation (FISH)
      with X chromosome specific probe. Our preliminary results revealed that about 70%
      of the cells exhibited karyotypic abnormalities including polyploidy, aneuploidy 
      and ring chromosomes. The heterogeneous spectrum of abnormalities indicates a
      high frequency of chromosomal mutations that continuously arise upon extended
      culture. These findings emphasise the need for the careful analysis of the
      cytogenetic stability of cultured hDSCs before they can be used in clinical
      therapies.
FAU - Duailibi, Monica Talarico
AU  - Duailibi MT
AD  - Department of Plastic Surgery, Federal University of Sao Paulo, UNIFESP CTCMol,
      Center of Cellular and Molecular Therapy, Sao Paulo, Brazil.
FAU - Kulikowski, Leslie Domenici
AU  - Kulikowski LD
FAU - Duailibi, Silvio Eduardo
AU  - Duailibi SE
FAU - Lipay, Monica Vannucci Nunes
AU  - Lipay MV
FAU - Melaragno, Maria Isabel
AU  - Melaragno MI
FAU - Ferreira, Lydia Masako
AU  - Ferreira LM
FAU - Vacanti, Joseph Phillip
AU  - Vacanti JP
FAU - Yelick, Pamela Crotty
AU  - Yelick PC
LA  - eng
GR  - R01 DE016132/DE/NIDCR NIH HHS/United States
GR  - R03TW007665/TW/FIC NIH HHS/United States
GR  - R01DE016132/DE/NIDCR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20111123
PL  - Netherlands
TA  - J Mol Histol
JT  - Journal of molecular histology
JID - 101193653
SB  - IM
MH  - Adult Stem Cells/*cytology
MH  - Cell Line
MH  - *Chromosome Aberrations
MH  - Chromosome Banding
MH  - Dental Pulp/*ultrastructure
MH  - *Genomic Instability
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
EDAT- 2011/11/24 06:00
MHDA- 2012/05/18 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/08/18 00:00 [received]
PHST- 2011/11/09 00:00 [accepted]
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2012/05/18 06:00 [medline]
AID - 10.1007/s10735-011-9373-z [doi]
PST - ppublish
SO  - J Mol Histol. 2012 Feb;43(1):89-94. doi: 10.1007/s10735-011-9373-z. Epub 2011 Nov
      23.


PMID- 22109699
OWN - NLM
STAT- MEDLINE
DCOM- 20140714
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 4
DP  - 2013 Dec
TI  - Teaching science, technology, and society to engineering students: a sixteen year
      journey.
PG  - 1439-50
LID - 10.1007/s11948-011-9329-4 [doi]
AB  - The course Science, Technology, and Society is taken by about 500 engineering
      students each year at Bilkent University, Ankara. Aiming to complement the highly
      technical engineering programs, it deals with the ethical, social, cultural,
      political, economic, legal, environment and sustainability, health and safety,
      reliability dimensions of science, technology, and engineering in a
      multidisciplinary fashion. The teaching philosophy and experiences of the
      instructor are reviewed. Community research projects have been an important
      feature of the course. Analysis of teaching style based on a multi-dimensional
      model is given. Results of outcome measurements performed for ABET assessment are
      provided. Challenges and solutions related to teaching a large class are
      discussed.
FAU - Ozaktas, Haldun M
AU  - Ozaktas HM
AD  - Department of Electrical Engineering, Bilkent University, 06800, Bilkent, Ankara,
      Turkey, haldun@ee.bilkent.edu.tr.
LA  - eng
PT  - Journal Article
DEP - 20111123
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
CIN - Sci Eng Ethics. 2013 Dec;19(4):1451-4. PMID: 24085355
MH  - *Curriculum
MH  - Engineering/*education/ethics
MH  - Ethics, Professional/*education
MH  - Humans
MH  - Science/*education/ethics
MH  - Students
MH  - *Teaching
MH  - Technology/*education/ethics
MH  - Turkey
MH  - *Universities
EDAT- 2011/11/24 06:00
MHDA- 2014/07/16 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/05/06 00:00 [received]
PHST- 2011/11/04 00:00 [accepted]
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2014/07/16 06:00 [medline]
AID - 10.1007/s11948-011-9329-4 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Dec;19(4):1439-50. doi: 10.1007/s11948-011-9329-4. Epub 2011
      Nov 23.


PMID- 22109088
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140611
LR  - 20161021
IS  - 0035-1776 (Print)
IS  - 0035-1776 (Linking)
VI  - 132
IP  - 4
DP  - 2011
TI  - [The problem of divisions, wagers, and game theory].
PG  - 529-63
LID - 10.1007/s11873-011-0166-z [doi]
AB  - This article looks at the "problem of the divisions" - a dialogue between two
      persons or more - to bring out its structure, in which religious and ethical
      elements are intermingled. It then offers a reevaluation of the argument of the
      wager, which is seen here as a sort of prefiguration of game theory rather than
      as the solution to a problem of probabilities. Although their correspondence
      suggests that Fermat and Pascal believed they were offering a solution to the
      same problem, they were not - as written by Fermat, the problem of divisions is a
      problem of probabilities, but ultimately Fermat did not solve the same problem as
      Pascal.
FAU - Clero, Jean-Pierre
AU  - Clero JP
AD  - Departement de philosophie, Universite de Haute-Normandie, rue Lavoisier,
      F-76821, Mont Saint Aignan cedex, France, jp.clero@orange.fr.
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Partis, Pari et Theorie des Jeux Teilungsprobleme, Wetten und Spieltheorie
      Puntos, Apuestas y Teoria de Juegos.
PL  - France
TA  - Rev Synth
JT  - Revue de synthese
JID - 8711586
EDAT- 2011/11/24 06:00
MHDA- 2011/11/24 06:01
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/11/24 06:01 [medline]
AID - 10.1007/s11873-011-0166-z [doi]
PST - ppublish
SO  - Rev Synth. 2011;132(4):529-63. doi: 10.1007/s11873-011-0166-z.


PMID- 22108790
OWN - NLM
STAT- MEDLINE
DCOM- 20120510
LR  - 20220409
IS  - 2210-7711 (Electronic)
VI  - 34
IP  - 1
DP  - 2012 Feb
TI  - Pharmacists' attitudes towards an evidence-based approach for over-the-counter
      medication.
PG  - 63-71
LID - 10.1007/s11096-011-9586-y [doi]
AB  - BACKGROUND: With increasing deregulation of prescription-only medicines and drive
      for self-care, pharmacists have greater scope to manage more conditions. This
      brings added responsibility to be competent healthcare professionals who deliver 
      high quality evidence-based patient care. OBJECTIVE: This study sought to
      establish pharmacists' attitudes towards an evidence based approach for
      over-the-counter medication. SETTING: Pharmacists working in community pharmacies
      across Northern Ireland. METHOD: Following ethical approval, a pre-piloted,
      self-completed questionnaire was distributed to all community pharmacies in
      Northern Ireland (n = 529) in September 2008. The development of the
      questionnaire was largely informed by the findings of a previous qualitative
      study. It consisted of six sections (mainly closed questions) covering factors
      that influence decisions regarding over-the-counter medication, recently
      deregulated prescription-only medicines, medications that lack evidence of
      effectiveness, knowledge of evidence-based practice, evidence-based practice with
      over-the-counter medication and demographic information. On receipt of
      questionnaires, responses to the closed questions were imported into SPSS((R))
      (version 17.0) for analysis which largely took the form of descriptive
      statistics. Chi-square and the Mann-Whitney U test were used for association
      between responses and demographic information with an a priori level of less than
      0.05 (P < 0.05) set as significant. MAIN OUTCOME MEASURE: Pharmacists' attitudes 
      and opinions in relation to decision making about over-the-counter medication and
      evidence of effectiveness were measured. RESULTS: A 39.5% (209/529) response rate
      was achieved. Most pharmacists [191/208 (91.8%)] 'strongly agreed' or 'agreed'
      that safety was the over-riding concern when dealing with over-the-counter
      medication. While 88.3% (181/205) 'strongly agreed' or 'agreed' that they were
      familiar with the concept of evidence-based practice, only 38.0% (78/205)
      'strongly agreed' or 'agreed' they knew how to critically appraise research
      papers. Furthermore, less than a quarter [49/205 (23.9%)] appeared to be familiar
      with the work of the Cochrane Collaboration. Most [188/207 (90.8%)] 'strongly
      agreed' or 'agreed' that regardless of evidence of effectiveness, cough medicines
      were an important management option. CONCLUSION: Safety was the primary concern
      when making decisions about over-the counter medicines. Pharmacists lacked
      knowledge of evidence-based practice and considered medicines which lacked
      evidence of effectiveness to have an important role in self-care. These factors
      present barriers to the widespread implementation of evidence-based practice.
FAU - Hanna, Lezley-Anne
AU  - Hanna LA
AD  - School of Pharmacy, Queen's University, Belfast, UK. l.hanna@qub.ac.uk
FAU - Hughes, Carmel M
AU  - Hughes CM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111123
PL  - Netherlands
TA  - Int J Clin Pharm
JT  - International journal of clinical pharmacy
JID - 101554912
RN  - 0 (Nonprescription Drugs)
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Community Pharmacy Services/*organization & administration
MH  - Decision Making
MH  - Evidence-Based Medicine/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Nonprescription Drugs/administration & dosage/*therapeutic use
MH  - Northern Ireland
MH  - Patient Care/methods
MH  - Pharmacists/organization & administration/*psychology
MH  - Pilot Projects
MH  - Self Medication
MH  - Statistics, Nonparametric
MH  - Surveys and Questionnaires
EDAT- 2011/11/24 06:00
MHDA- 2012/05/11 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/07/15 00:00 [received]
PHST- 2011/11/07 00:00 [accepted]
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2012/05/11 06:00 [medline]
AID - 10.1007/s11096-011-9586-y [doi]
PST - ppublish
SO  - Int J Clin Pharm. 2012 Feb;34(1):63-71. doi: 10.1007/s11096-011-9586-y. Epub 2011
      Nov 23.


PMID- 22108580
OWN - NLM
STAT- MEDLINE
DCOM- 20120524
LR  - 20120322
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 4
DP  - 2012 Apr
TI  - Sturdy for common things: cultivating moral sensemaking on the front lines of
      practice.
PG  - 233-5
LID - 10.1136/medethics-2011-100084 [doi]
AB  - This essay argues that the field of bioethics should concern itself especially
      with the process of making moral sense that unfolds among clinicians, patients
      and family members during common but high-stakes conversations occurring on the
      front lines of practice. The essay outlines the parameters of a bioethics
      grounded in the moral experience of patients, families and practitioners. It
      challenges ethicists, educators, and clinician leaders to commit themselves to
      advocating and developing creative approaches to learning that will cultivate the
      moral sensibilities of frontline clinicians in this critically important domain
      of practice.
FAU - Browning, David M
AU  - Browning DM
AD  - Institute for Professionalism and Ethical Practice, Children's Hospital Boston at
      Waltham, Waltham, MA 02453, USA. david.browning@childrens.harvard.edu
LA  - eng
PT  - Journal Article
DEP - 20111121
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Bioethics
MH  - Family/*psychology
MH  - Humans
MH  - *Morals
MH  - Physician-Patient Relations/*ethics
MH  - Professional Practice/*standards
EDAT- 2011/11/24 06:00
MHDA- 2012/05/25 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2012/05/25 06:00 [medline]
AID - medethics-2011-100084 [pii]
AID - 10.1136/medethics-2011-100084 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Apr;38(4):233-5. doi: 10.1136/medethics-2011-100084. Epub 2011
      Nov 21.


PMID- 22108502
OWN - NLM
STAT- MEDLINE
DCOM- 20120820
LR  - 20121010
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 153
IP  - 3
DP  - 2011 Dec 15
TI  - Statement on authorship and publishing ethics in the International Journal of
      Cardiology.
PG  - 239-40
LID - 10.1016/j.ijcard.2011.10.119 [doi]
FAU - Coats, Andrew J S
AU  - Coats AJ
FAU - Shewan, Louise G
AU  - Shewan LG
LA  - eng
PT  - Editorial
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
SB  - IM
MH  - *Authorship
MH  - Cardiology/*ethics
MH  - Ethics, Professional
MH  - Humans
MH  - Periodicals as Topic/*ethics
MH  - Publishing/*ethics
EDAT- 2011/11/24 06:00
MHDA- 2012/08/21 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/10/22 00:00 [received]
PHST- 2011/10/22 00:00 [accepted]
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2012/08/21 06:00 [medline]
AID - S0167-5273(11)01994-2 [pii]
AID - 10.1016/j.ijcard.2011.10.119 [doi]
PST - ppublish
SO  - Int J Cardiol. 2011 Dec 15;153(3):239-40. doi: 10.1016/j.ijcard.2011.10.119.


PMID- 22107003
OWN - NLM
STAT- MEDLINE
DCOM- 20120124
LR  - 20190902
IS  - 1326-5377 (Electronic)
IS  - 0025-729X (Linking)
VI  - 195
IP  - 10
DP  - 2011 Nov 21
TI  - A case study of a single ethics committee for multicentre trials.
PG  - 582-3
FAU - Olver, Ian N
AU  - Olver IN
FAU - Falleiro, Sharon J P
AU  - Falleiro SJ
FAU - Marson, Marion L
AU  - Marson ML
FAU - Bishop, James F
AU  - Bishop JF
LA  - eng
PT  - Comparative Study
PT  - Letter
PL  - Australia
TA  - Med J Aust
JT  - The Medical journal of Australia
JID - 0400714
SB  - IM
MH  - Australia
MH  - Clinical Trials as Topic/*ethics
MH  - Ethical Review/*standards
MH  - Ethics Committees, Clinical/ethics/*standards
MH  - Female
MH  - Humans
MH  - Male
MH  - Multicenter Studies as Topic/*ethics
MH  - Neoplasms/diagnosis/therapy
MH  - Quality Control
EDAT- 2011/11/24 06:00
MHDA- 2012/01/25 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/04/16 00:00 [received]
PHST- 2011/10/13 00:00 [accepted]
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2012/01/25 06:00 [medline]
AID - letters_211111_fm-5 [pii]
AID - 10.5694/mja11.10484 [doi]
PST - ppublish
SO  - Med J Aust. 2011 Nov 21;195(10):582-3. doi: 10.5694/mja11.10484.


PMID- 22106746
OWN - NLM
STAT- MEDLINE
DCOM- 20111213
LR  - 20111123
IS  - 1934-4287 (Print)
IS  - 1934-4287 (Linking)
VI  - 22
IP  - 2
DP  - 2011 Aug
TI  - Law, ethics, and clinical discretion: recurring and emerging issues in adolescent
      health care.
PG  - 321-34, xi
AB  - Varied stakeholders are involved in adolescent health care, with many looking to 
      law to provide clear-cut answers on who can control decisions and when. However, 
      law allows for much clinician discretion, carving out space for contextual
      sensitivity and clinical determination of maturity. A triad model of
      decision-making is very often the most appropriate clinical and ethical course.
      Law's aim is ideally not to impede, but rather to support clinical and ethical
      wisdom. Drawing on cases in this volume, it is argued that law should not and
      typically does not, when accurately interpreted and applied, stand in clinicians'
      way.
FAU - Campbell, Amy T
AU  - Campbell AT
AD  - SUNY Upstate Medical University and Syracuse University College of Law
      (courtesy), 618 Irving Avenue, Syracuse, New York 13210, USA.
      campbela@upstate.edu
FAU - English, Abigail
AU  - English A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Adolesc Med State Art Rev
JT  - Adolescent medicine: state of the art reviews
JID - 101314248
SB  - IM
MH  - Adolescent
MH  - Adolescent Health Services/*ethics/*legislation & jurisprudence
MH  - Confidentiality
MH  - Decision Making
MH  - Genetic Testing
MH  - Humans
MH  - Treatment Refusal
EDAT- 2011/11/24 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
PST - ppublish
SO  - Adolesc Med State Art Rev. 2011 Aug;22(2):321-34, xi.


PMID- 22106745
OWN - NLM
STAT- MEDLINE
DCOM- 20111213
LR  - 20161125
IS  - 1934-4287 (Print)
IS  - 1934-4287 (Linking)
VI  - 22
IP  - 2
DP  - 2011 Aug
TI  - Sexual exploitation and trafficking of the young and vulnerable: reflections on a
      legal, ethical, and human rights disgrace.
PG  - 312-20, xi
AB  - Sexual exploitation and trafficking of the young and vulnerable has devastating
      consequences for their physical and emotional development, health, and
      well-being. The horrific treatment they suffer bears the hallmarks of evil made
      manifest. Governments have enacted laws pursuant to international treaties,
      conventions, and protocols. Nonprofit and nongovernmental organizations (NGOs)
      are working to prevent young people from being exploited and trafficked, to
      identify victims, and to provide services to survivors. Progress in addressing
      the problem is haltingly slow in relation to its magnitude. The prevalence and
      persistence of this phenomenon is an ethical, legal, and human rights disgrace.
FAU - English, Abigail
AU  - English A
AD  - Center for Adolescent Health & the Law, P.O. Box 3795, Chapel Hill, North
      Carolina 27515, USA. english@cahl.org
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Adolesc Med State Art Rev
JT  - Adolescent medicine: state of the art reviews
JID - 101314248
SB  - IM
MH  - Adolescent
MH  - Crime/*ethics/*legislation & jurisprudence
MH  - Female
MH  - *Human Rights
MH  - Humans
MH  - *Internationality
MH  - Male
MH  - *Sex Work
MH  - Vulnerable Populations
EDAT- 2011/11/24 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
PST - ppublish
SO  - Adolesc Med State Art Rev. 2011 Aug;22(2):312-20, xi.


PMID- 22106744
OWN - NLM
STAT- MEDLINE
DCOM- 20111213
LR  - 20111123
IS  - 1934-4287 (Print)
IS  - 1934-4287 (Linking)
VI  - 22
IP  - 2
DP  - 2011 Aug
TI  - Health rights, health ethics, and adolescence: addressing current challenges,
      ensuring a just future.
PG  - 301-11, xi
AB  - This article presents a discussion of the human rights declarations that address 
      adolescent health, including reference to specific articles in the declarations
      that address this population; examples of ethical issues related to health that
      are faced by adolescents, their families, and providers who care for them; and
      ethical principles and frameworks that can serve as a basis for consideration of 
      these issues. The article also includes examples of circumstances that pose
      ethical dilemmas for clinicians and adolescent clients and their families.
FAU - Eisenstein, Evelyn
AU  - Eisenstein E
AD  - Medical School of the University of the State of Rio de Janeiro, Brazil.
      evelynbrasil@hotmail.com
FAU - Jillson, Irene Anne
AU  - Jillson IA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Adolesc Med State Art Rev
JT  - Adolescent medicine: state of the art reviews
JID - 101314248
SB  - IM
MH  - Adolescent
MH  - Adolescent Health Services/*ethics
MH  - Child
MH  - *Human Rights
MH  - Humans
MH  - Young Adult
EDAT- 2011/11/24 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
PST - ppublish
SO  - Adolesc Med State Art Rev. 2011 Aug;22(2):301-11, xi.


PMID- 22106743
OWN - NLM
STAT- MEDLINE
DCOM- 20111213
LR  - 20111123
IS  - 1934-4287 (Print)
IS  - 1934-4287 (Linking)
VI  - 22
IP  - 2
DP  - 2011 Aug
TI  - Iatrogenesis: ethical and legal aspects.
PG  - 289-300, x-xi
AB  - This article describes iatrogenic events, giving examples that range from
      individual error to systemic malfunctions. It then goes on to analyze individual 
      and system responsibilities in the disclosure of iatrogenic events. A discussion 
      follows on the physician's responsibility, professional integrity, "duty to
      warn", and transparency as they relate to error disclosure, including an
      examination of the role of apology and repair in the setting of iatrogenesis. It 
      concludes by considering the moral and legal operational implications of
      iatrogenic events and the building of a culture of safety.
FAU - Silber, Tomas J
AU  - Silber TJ
AD  - Pediatric Ethics Program, Division of Adolescent Medicine, Children's National
      Medical Center, USA. tsilber@childrensnational.org
FAU - Hilliard, Mary Anne
AU  - Hilliard MA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Adolesc Med State Art Rev
JT  - Adolescent medicine: state of the art reviews
JID - 101314248
SB  - IM
MH  - *Adolescent Medicine
MH  - Humans
MH  - *Iatrogenic Disease
MH  - Liability, Legal
MH  - Medical Errors/*ethics/*legislation & jurisprudence
MH  - Organizational Culture
MH  - Safety Management
MH  - Truth Disclosure/ethics
EDAT- 2011/11/24 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
PST - ppublish
SO  - Adolesc Med State Art Rev. 2011 Aug;22(2):289-300, x-xi.


PMID- 22106742
OWN - NLM
STAT- MEDLINE
DCOM- 20111213
LR  - 20111123
IS  - 1934-4287 (Print)
IS  - 1934-4287 (Linking)
VI  - 22
IP  - 2
DP  - 2011 Aug
TI  - Treatment of anorexia nervosa against the patient's will: ethical considerations.
PG  - 283-8, x
AB  - By the nature of their illness, many if not most patients with anorexia nervosa
      are treated against their will. This article explores the issue of patient
      autonomy and right to treatment refusal in the light of justified paternalism as 
      well as a more enriched understanding of autonomy in the context of
      relationships. A summary follows on the research on patients' perceptions and
      response to involuntary treatment. The conclusion addresses the importance of
      human values intrinsic to the quality of a clinical relationship as determinant
      for patient recovery and professional satisfaction.
FAU - Silber, Tomas J
AU  - Silber TJ
AD  - Pediatric Ethics Program, Division of Adolescent Medicine, Children's National
      Medical Center, USA. tsilber@childrensnational.org
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Adolesc Med State Art Rev
JT  - Adolescent medicine: state of the art reviews
JID - 101314248
SB  - IM
MH  - Anorexia Nervosa/psychology/*therapy
MH  - Humans
MH  - Paternalism/*ethics
MH  - Treatment Refusal/*ethics/psychology
EDAT- 2011/11/24 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
PST - ppublish
SO  - Adolesc Med State Art Rev. 2011 Aug;22(2):283-8, x.


PMID- 22106740
OWN - NLM
STAT- MEDLINE
DCOM- 20111213
LR  - 20111123
IS  - 1934-4287 (Print)
IS  - 1934-4287 (Linking)
VI  - 22
IP  - 2
DP  - 2011 Aug
TI  - Cancer therapy and the preservation of adolescent fertility.
PG  - 265-76, ix-x
AB  - The increasing survival of adolescents with cancer, achieved through intensive
      therapy, is often associated with sterility. For most teenagers, the ability to
      have biological children is psychologically and socially important. Methods of
      preserving fertility, some standard and other experimental, have proliferated,
      but their use raises ethical issues. This review poses three hypothetical cases, 
      describes the preservation methods, and identifies and analyzes the ethical
      issues. The discussion asks what needs to be told, who decides what to do, when
      can a pediatrician refuse to follow a family's choice, and what is the
      pediatrician's role as advocate for adolescents.
FAU - Forman, Edwin N
AU  - Forman EN
AD  - Pediatric Hematology/Oncology, Mount Sinai School of Medicine, One Gustave L.
      Levy Place, Box 1208, New York, NY 10029-6574, USA. Formae01@mssm.edu
FAU - Ladd, Rosalind Ekman
AU  - Ladd RE
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Adolesc Med State Art Rev
JT  - Adolescent medicine: state of the art reviews
JID - 101314248
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Adolescent
MH  - Adolescent Medicine/ethics/*methods
MH  - Antineoplastic Agents/*adverse effects
MH  - Cryopreservation
MH  - *Decision Making
MH  - Humans
MH  - Infertility/*chemically induced
MH  - Parents
MH  - Sex Factors
EDAT- 2011/11/24 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
PST - ppublish
SO  - Adolesc Med State Art Rev. 2011 Aug;22(2):265-76, ix-x.


PMID- 22106739
OWN - NLM
STAT- MEDLINE
DCOM- 20111213
LR  - 20171116
IS  - 1934-4287 (Print)
IS  - 1934-4287 (Linking)
VI  - 22
IP  - 2
DP  - 2011 Aug
TI  - Ethical and policy issues raised by heterozygote carrier identification and
      predictive genetic testing of adolescents.
PG  - 251-64, ix
AB  - Current professional recommendations discourage health care providers from
      providing heterozygote carrier testing and predictive genetic testing for
      adult-onset conditions to minors. These recommendations are based on theoretical 
      concerns that the harms outweigh the benefits. Although empirical data are scant,
      the emerging evidence suggests that the risks of harms are less than predicted
      and that there may be some significant benefits for testing adolescents,
      particularly when the adolescent and parent(s) agree. To ethically respond to
      requests for genetic testing of adolescents, pediatricians should evaluate the
      goals of testing, the familial implications of the results, and whose consent is 
      needed.
FAU - Ross, Lainie Friedman
AU  - Ross LF
AD  - Department of Pediatrics, MacLean Center for Clinical Medical Ethics, University 
      of Chicago, 5841 South Maryland Avenue, MC 6082, Chicago, IL 60637, USA.
      lross@uchicago.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Adolesc Med State Art Rev
JT  - Adolescent medicine: state of the art reviews
JID - 101314248
SB  - IM
MH  - Adolescent
MH  - *Genetic Carrier Screening
MH  - Genetic Testing/*ethics/*legislation & jurisprudence
MH  - Humans
MH  - Parents
MH  - Paternity
MH  - *Policy
EDAT- 2011/11/24 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
PST - ppublish
SO  - Adolesc Med State Art Rev. 2011 Aug;22(2):251-64, ix.


PMID- 22106737
OWN - NLM
STAT- MEDLINE
DCOM- 20111213
LR  - 20111123
IS  - 1934-4287 (Print)
IS  - 1934-4287 (Linking)
VI  - 22
IP  - 2
DP  - 2011 Aug
TI  - The aftermath of adolescent suicide: clinical, ethical, and spiritual issues.
PG  - 229-39, ix
AB  - The aftermath of an adolescent's suicide can be devastating to family, friends,
      and treating professionals, yet not much has been written on this subject. In
      this article, we briefly develop a conceptualization of suicide and a typology of
      suicide and the physicians' attitudes toward suicide. This is followed with a
      more detailed review of the aftermath of suicide (focusing on the suicide
      grievers) and the impact of suicide on clinicians. The work ends with discussion 
      of research data and the role of spirituality as well as an outline of
      therapeutic interventions.
FAU - Girard, Gustavo A
AU  - Girard GA
AD  - Adolescent Health Program, Hospital Clinicas Jose de San Martin, Buenos Aires,
      Argentina. gagirard@ciudad.com.ar
FAU - Silber, Tomas J
AU  - Silber TJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Adolesc Med State Art Rev
JT  - Adolescent medicine: state of the art reviews
JID - 101314248
SB  - IM
MH  - Adolescent
MH  - Adolescent Behavior/*psychology
MH  - Attitude of Health Personnel
MH  - *Grief
MH  - Humans
MH  - Parents
MH  - Peer Group
MH  - Religion and Psychology
MH  - Siblings
MH  - Suicide/*psychology
EDAT- 2011/11/24 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
PST - ppublish
SO  - Adolesc Med State Art Rev. 2011 Aug;22(2):229-39, ix.


PMID- 22106734
OWN - NLM
STAT- MEDLINE
DCOM- 20111213
LR  - 20141120
IS  - 1934-4287 (Print)
IS  - 1934-4287 (Linking)
VI  - 22
IP  - 2
DP  - 2011 Aug
TI  - Making sense of adolescent decision-making: challenge and reality.
PG  - 195-206, vii-viii
AB  - Few topics in pediatric bioethics are as vexing as decision-making.
      Decision-making in pediatrics presents challenges for children, parents, and
      physicians alike. The related, yet distinct, concepts of assent and consent are
      central to pediatric decision-making. Although informed consent is largely
      regarded as a worthwhile adult principle, assent has been, and continues to be,
      mired in debate. Controversial subjects include a meaningful definition of
      assent; how old children should be to assent; who should be included in the
      assent process; parental permission; how to resolve disputes between children and
      their parents; the relationship between assent and consent; the quantity and
      quality of information to disclose to children and their families; how much and
      what information children desire and need; the necessity and methods for
      assessing both children's understanding of disclosed information and of the
      assent process itself; reconciling ethical and legal attitudes toward assent; and
      finally, an effective, practical, and realistically applicable decision-making
      model.
FAU - Unguru, Yoram
AU  - Unguru Y
AD  - Division of Pediatric Hematology/Oncology, The Herman and Walter Samuelson
      Children's Hospital at Sinai, 2401 West Belvedere Avenue, Baltimore, Maryland
      21215-5271, USA. yunguru@lifebridgehealth.org
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Adolesc Med State Art Rev
JT  - Adolescent medicine: state of the art reviews
JID - 101314248
SB  - IM
MH  - Adolescent
MH  - Adolescent Medicine/ethics/legislation & jurisprudence
MH  - *Decision Making
MH  - Disclosure
MH  - Humans
MH  - Male
MH  - *Parents
MH  - *Physician-Patient Relations
MH  - Psychology, Adolescent/ethics/legislation & jurisprudence
MH  - Public Opinion
MH  - Testicular Neoplasms/*psychology
EDAT- 2011/11/24 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
PST - ppublish
SO  - Adolesc Med State Art Rev. 2011 Aug;22(2):195-206, vii-viii.


PMID- 22106732
OWN - NLM
STAT- MEDLINE
DCOM- 20111213
LR  - 20111123
IS  - 1934-4287 (Print)
IS  - 1934-4287 (Linking)
VI  - 22
IP  - 2
DP  - 2011 Aug
TI  - Conscience, clinical ethics, and emergency contraception.
PG  - 175-82, vii
AB  - Emergency contraception (EC) is a generic term used to describe a group of
      hormonal methods taken within the first few days after unprotected sexual
      intercourse to prevent an unintended pregnancy. EC is safe and effective in
      preventing pregnancy. Plan B or the generic levonorgestrel is available
      over-the-counter for women 17 years and older. A prescription is still required
      for women younger than 17 years of age. Even with its safety, effectiveness, and 
      ease of accessibility for older adolescents and women, EC remains morally
      controversial. This article reviews the development of EC, presents data on the
      prevalence of conscientious objection, discusses how the change in status from
      prescription drug to over-the-counter medication has changed the debate, and
      makes recommendations for dealing with the controversies.
FAU - Plantz, Diane
AU  - Plantz D
AD  - University of Missouri at Kansas City, Section of Emergency Medicine, Children's 
      Mercy Hospitals and Clinics, 2401 Gillham Road, Kansas City, MO 64108, USA.
      dmplantz@cmh.edu
FAU - Lantos, John D
AU  - Lantos JD
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Adolesc Med State Art Rev
JT  - Adolescent medicine: state of the art reviews
JID - 101314248
RN  - 0 (Nonprescription Drugs)
RN  - 0 (Prescription Drugs)
SB  - IM
MH  - Adolescent
MH  - Adolescent Medicine/ethics
MH  - *Conscience
MH  - Contraception, Postcoital/*ethics
MH  - Female
MH  - Humans
MH  - Nonprescription Drugs
MH  - Pharmacists/ethics
MH  - Pregnancy
MH  - Pregnancy in Adolescence/prevention & control
MH  - Prescription Drugs
MH  - United States
EDAT- 2011/11/24 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
PST - ppublish
SO  - Adolesc Med State Art Rev. 2011 Aug;22(2):175-82, vii.


PMID- 22106731
OWN - NLM
STAT- MEDLINE
DCOM- 20111213
LR  - 20111123
IS  - 1934-4287 (Print)
IS  - 1934-4287 (Linking)
VI  - 22
IP  - 2
DP  - 2011 Aug
TI  - Ethical and legal issues in adolescent medicine. Preface.
PG  - xiii-xiv
FAU - Silber, Tomas J
AU  - Silber TJ
FAU - English, Abigail
AU  - English A
LA  - eng
PT  - Introductory Journal Article
PL  - United States
TA  - Adolesc Med State Art Rev
JT  - Adolescent medicine: state of the art reviews
JID - 101314248
SB  - IM
MH  - Adolescent Medicine/*ethics/*legislation & jurisprudence
MH  - Humans
EDAT- 2011/11/24 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
PST - ppublish
SO  - Adolesc Med State Art Rev. 2011 Aug;22(2):xiii-xiv.


PMID- 22106692
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20211203
IS  - 0300-5283 (Print)
IS  - 0300-5283 (Linking)
VI  - 66
IP  - 2
DP  - 2011 Jun
TI  - The association between GJB2 mutation and GJB6 gene in non syndromic hearing loss
      school children.
PG  - 124-8
AB  - Recently, molecular testing for GJB2 mutations has become the standard of care
      for the diagnosis of patients with non syndromic hearing impairment of unknown
      cause. The aims of this study are to determine the association between GJB2
      mutation and GJB6 and to report the variation of mutations in deaf students who
      have heterozygous GJB2. This retrospective study was conducted at Universiti
      Kebangsaan Malaysia Medical Center (UKMMC). Data was collected from previous
      files and records from Tissue Engineering and Human Genetic Research Group
      Laboratory. Approval from Ethical Committee was obtained prior to the study. A
      total of 138 students have been screened in previous studies in UKMMC for the
      presence of GJB2 mutations as a cause for hearing loss. Thirty four of the 138
      subjects have GJB2 mutations; 2 showed homozygous mutations whereas another 32
      were heterozygous for GJB2 gene mutation. Only 31 DNA samples of students
      presented with sensorineural hearing loss with heterozygous mutation in GJB2 gene
      were included in this study. The sequencing results obtained were analyzed. The
      degree of hearing loss of those students with association between GJB2 mutation
      and GJB6 mutation will be discussed. Five out of 31 subjects (16.2%) have
      mutations in their GJB6 gene, suggesting a digenic inheritance of GJB2/GJB6
      mutation. In total, four novel mutations were identified; E137D (n=1), R32Q
      (n=1), E101K (n=1) and Y156H (n=1) and one mutation deletion; 366delT (n=1). All 
      students with association GJB2 mutation and GJB6 showed severe to profound
      hearing loss in both ears. Interestingly this study not detected the large
      deletion of 342 kb in GJB6 gene suggesting that the mutation is very rare in this
      region compared to certain parts of the world.
FAU - Asma, A
AU  - Asma A
AD  - Department of Otorhinolaryngology, Head & Neck Surgery, Universiti Kebangsaan
      Malaysia Medical Center, Kuala Lumpur, Malaysia. asmaent@yahoo.com
FAU - Ashwaq, A
AU  - Ashwaq A
FAU - Norzana, A G
AU  - Norzana AG
FAU - Atmadini, A Maizaton
AU  - Atmadini AM
FAU - Ruszymah, B H I
AU  - Ruszymah BH
FAU - Saim, L
AU  - Saim L
FAU - Wahida, I Farah
AU  - Wahida IF
LA  - eng
PT  - Journal Article
PL  - Malaysia
TA  - Med J Malaysia
JT  - The Medical journal of Malaysia
JID - 0361547
RN  - 0 (Connexin 30)
RN  - 0 (Connexins)
RN  - 0 (GJB2 protein, human)
RN  - 0 (GJB6 protein, human)
RN  - 127120-53-0 (Connexin 26)
SB  - IM
MH  - Adolescent
MH  - Asians/*genetics
MH  - Child
MH  - Connexin 26
MH  - Connexin 30
MH  - Connexins/*genetics
MH  - Female
MH  - Hearing Loss, Sensorineural/ethnology/*genetics
MH  - Humans
MH  - Malaysia
MH  - Male
MH  - Mutation/*genetics
MH  - Retrospective Studies
EDAT- 2011/11/24 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
PST - ppublish
SO  - Med J Malaysia. 2011 Jun;66(2):124-8.


PMID- 22106676
OWN - NLM
STAT- MEDLINE
DCOM- 20111226
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 8
IP  - 4
DP  - 2011 Oct-Dec
TI  - Euthanasia: ethical risks.
PG  - 261-2
FAU - Mishra, Prasanna K
AU  - Mishra PK
LA  - eng
PT  - Letter
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Euthanasia/*ethics
MH  - Humans
MH  - India
MH  - Motion Pictures
MH  - *Professional Misconduct
MH  - *Trust
EDAT- 2011/11/24 06:00
MHDA- 2011/12/27 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/27 06:00 [medline]
AID - 10.20529/IJME.2011.100 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2011 Oct-Dec;8(4):261-2. doi: 10.20529/IJME.2011.100.


PMID- 22106673
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111226
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 8
IP  - 4
DP  - 2011 Oct-Dec
TI  - Ethics in cluster randomised trials: a grey zone.
PG  - 253-4
FAU - Bhan, Anant
AU  - Bhan A
AD  - anantbhan@gmail.com
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
CON - Trials. 2011;12:100. PMID: 21507237
EDAT- 2011/11/24 06:00
MHDA- 2011/11/24 06:01
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/11/24 06:01 [medline]
AID - 10.20529/IJME.2011.097 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2011 Oct-Dec;8(4):253-4. doi: 10.20529/IJME.2011.097.


PMID- 22106670
OWN - NLM
STAT- MEDLINE
DCOM- 20111226
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 8
IP  - 4
DP  - 2011 Oct-Dec
TI  - When the patient's family refuses care: a practical ethical dilemma.
PG  - 248-9
FAU - Gopichandran, Vijay
AU  - Gopichandran V
AD  - Rural Women's Social Education Centre Reproductive Health Clinic, 61,
      Karumarapakkam Village, Veerapuram Post, Kanchipuram District, Tamil Nadu 603
      009, India. vijay.gopichandran@gmail.com
FAU - Gaitonde, Rakhal
AU  - Gaitonde R
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
CIN - Indian J Med Ethics. 2011 Oct-Dec;8(4):249-51. PMID: 22106671
MH  - Abdomen, Acute/*surgery
MH  - Ethics, Medical
MH  - Family Relations/*ethnology
MH  - Humans
MH  - India
MH  - Medicine, Traditional
MH  - Population Groups
MH  - Treatment Refusal/*ethics/ethnology
EDAT- 2011/11/24 06:00
MHDA- 2011/12/27 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/27 06:00 [medline]
AID - 10.20529/IJME.2011.094 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2011 Oct-Dec;8(4):248-9. doi: 10.20529/IJME.2011.094.


PMID- 22106667
OWN - NLM
STAT- MEDLINE
DCOM- 20111226
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 8
IP  - 4
DP  - 2011 Oct-Dec
TI  - The ethics of live surgery: an ongoing debate.
PG  - 244-5
FAU - Morekar, Sunil
AU  - Morekar S
AD  - Cumballa Hill Hospital, August Kranti Marg, Mumbai 400 036, India.
      morekarsunil@gmail.com
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
CIN - Indian J Med Ethics. 2011 Oct-Dec;8(4):245. PMID: 22106668
MH  - Ethics, Medical
MH  - Humans
MH  - India
MH  - Patient Safety
MH  - Surgical Procedures, Operative/*ethics
MH  - Television/*ethics
MH  - United States
EDAT- 2011/11/24 06:00
MHDA- 2011/12/27 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/27 06:00 [medline]
AID - 10.20529/IJME.2011.091 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2011 Oct-Dec;8(4):244-5. doi: 10.20529/IJME.2011.091.


PMID- 22106664
OWN - NLM
STAT- MEDLINE
DCOM- 20111226
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 8
IP  - 4
DP  - 2011 Oct-Dec
TI  - Planning and response to the influenza A (H1N1) pandemic: ethics, equity and
      justice.
PG  - 237-40
AB  - This paper aims to highlight three ethical considerations related to influenza
      pandemic planning and response: ethical allocation of scarce resources;
      obligations and duties of healthcare workers to treat patients, and the balance
      between conflicting individual and community interests. Among these, perhaps the 
      most challenging question facing bioethics is how to allocate scarce, life-saving
      resources given the devastating social and economic ramifications of a pandemic. 
      In such situations, the identification of clear overall goals for pandemic
      planning is essential in making difficult choices. The dilemma between the duty
      to save patients and the right to protect the healthcare personnel's own life and
      health is a key issue. During the course of a pandemic, civil liberties may also 
      be threatened, requiring limits on individual freedom to protect individuals as
      well as entire communities. Yet, individual liberty should be restricted with
      great care, and only when alternative approaches are not effective. Pandemic
      influenza planning and response should be a cooperative and shared responsibility
      that balances community and individual interests.
FAU - Devnani, Mahesh
AU  - Devnani M
AD  - Department of Hospital Administration, Post Graduate Institute of Medical
      Education and Research, Chandigarh, India. devnaniji@gmail.com
FAU - Gupta, Anil Kumar
AU  - Gupta AK
FAU - Devnani, Bharti
AU  - Devnani B
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - *Disaster Planning
MH  - Epidemics/*prevention & control
MH  - *Ethics, Medical
MH  - Health Care Rationing/ethics
MH  - Humans
MH  - India/epidemiology
MH  - *Influenza A Virus, H1N1 Subtype
MH  - Influenza, Human/*prevention & control
MH  - Moral Obligations
MH  - Patient Isolation/ethics
MH  - Quarantine/ethics
EDAT- 2011/11/24 06:00
MHDA- 2011/12/27 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/27 06:00 [medline]
AID - 10.20529/IJME.2011.088 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2011 Oct-Dec;8(4):237-40. doi: 10.20529/IJME.2011.088.


PMID- 22106662
OWN - NLM
STAT- MEDLINE
DCOM- 20111226
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 8
IP  - 4
DP  - 2011 Oct-Dec
TI  - Bringing back Aristotle.
PG  - 230-3
AB  - Ethical analysis in medicine has been dominated by an approach derived from "the 
      four principles" which focus on actions. By contrast, consideration of the
      virtues emphasises the importance of the moral agent. A renewed emphasis on
      virtue ethics, not as a rival, but integrated into deontological ethics is
      proposed.
FAU - Saunders, John
AU  - Saunders J
AD  - School of Health Science, Swansea University, SA99 8PPWales, UK.
      saundersjohn@doctors.org.uk
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Ethical Analysis/*methods
MH  - Ethical Theory
MH  - *Ethics, Medical/education
MH  - Humans
MH  - Philosophy
MH  - *Virtues
EDAT- 2011/11/24 06:00
MHDA- 2011/12/27 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/27 06:00 [medline]
AID - 10.20529/IJME.2011.086 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2011 Oct-Dec;8(4):230-3. doi: 10.20529/IJME.2011.086.


PMID- 22106661
OWN - NLM
STAT- MEDLINE
DCOM- 20111226
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 8
IP  - 4
DP  - 2011 Oct-Dec
TI  - Impact of UNCRPD on the status of persons with disabilities.
PG  - 223-9
AB  - The sanctity of human life is a fundamental human value and the medical
      profession has been ethically charged with respecting and enhancing the value of 
      all human beings' lives. However, disability-selective abortion has been
      perceived as an acceptable health intervention to eliminate disabilities, and is 
      provided for in law as well as in policies and healthcare programmes related to
      disability. Advanced medical technologies are being utilised not to maximise the 
      lives of persons with disabilities but to prevent the birth of disabled people by
      medically terminating foetuses diagnosed with disability. Evidently, disability
      is seen as undesirable per se by society, and life with disability as not worth
      living. The disability rights perspective argues that such laws, policies and
      programmes deny persons with disabilities the right to life and thereby
      discriminate against them. They violate the United Nations Convention on the
      Rights of Persons with Disabilities that recognises the inherent human dignity of
      all human beings and treats persons with disabilities on an equal basis with all 
      other human beings. This paper examines the question of whether
      disability-selective abortion as a prevention strategy diminishes the value of
      persons with disabilities, in the context of the right to life and dignity of
      life accorded by the UNCRPD to persons with disabilities. This is discussed in
      the context of a selected summary of international and Indian policy and law on
      this subject.
FAU - Nizar, Smitha
AU  - Nizar S
AD  - NALSAR University of Law, Hyderabad AP 500 078, India. smithanizar@gmail.com
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
CIN - Indian J Med Ethics. 2013 Jan-Mar;10(1):70-1. PMID: 23439207
MH  - Abortion, Eugenic/*ethics/*legislation & jurisprudence
MH  - Disabled Persons/*legislation & jurisprudence
MH  - Human Rights/*legislation & jurisprudence
MH  - Humans
MH  - India
MH  - Prenatal Diagnosis
MH  - United Nations
MH  - Wrongful Life
EDAT- 2011/11/24 06:00
MHDA- 2011/12/27 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/27 06:00 [medline]
AID - 10.20529/IJME.2011.085 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2011 Oct-Dec;8(4):223-9. doi: 10.20529/IJME.2011.085.


PMID- 22106660
OWN - NLM
STAT- MEDLINE
DCOM- 20111226
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 8
IP  - 4
DP  - 2011 Oct-Dec
TI  - Considering ethics in community eye health planning: perspectives from an
      existing model.
PG  - 216-23
AB  - Despite the widespread acceptance of the principles of the Alma Ata Declaration
      of 1978 and the subsequent amendments, health for all has remained a distant
      dream in many parts of the developing world. Concerns such as the economic
      efficiency of health systems and their reach and coverage have dominated
      discussions of public health, with ethics remaining at best a shadowy set of
      assumptions or at worst completely ignored. Similarly, questions of ethics have
      been taken for granted and rarely addressed directly in the design of public
      health models across sectors and are rarely explicitly addressed. This paper uses
      the experience of the L V Prasad Eye Institute's (LVPEI) pyramidal model of eye
      healthcare delivery to explore ethical issues in the design and implementation of
      public health interventions. The LVPEI model evolved over time from its
      beginnings as a tertiary care centre to a network that spans all levels of eye
      care service delivery from the community through primary and secondary levels. A 
      previously published analytical framework is applied to this model and the
      utility of this framework as well as the ethics of the LVPEI model are
      interrogated. An analytical and prescriptive framework is then evolved that could
      be used to build in and evaluate ethics in other public health delivery models.
FAU - Raman, Usha
AU  - Raman U
AD  - L V Prasad Eye Institute, Hyderabad, India. usha.raman@gmail.com
FAU - Sheeladevi, Sethu
AU  - Sheeladevi S
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Blindness/*prevention & control
MH  - Community Health Planning/*ethics/methods
MH  - Developing Countries
MH  - Ethical Analysis/*methods
MH  - Health Plan Implementation/ethics
MH  - Health Promotion/*ethics/organization & administration
MH  - Humans
MH  - India
MH  - Needs Assessment/ethics
EDAT- 2011/11/24 06:00
MHDA- 2011/12/27 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/27 06:00 [medline]
AID - 10.20529/IJME.2011.084 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2011 Oct-Dec;8(4):216-23. doi: 10.20529/IJME.2011.084.


PMID- 22106659
OWN - NLM
STAT- MEDLINE
DCOM- 20111226
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 8
IP  - 4
DP  - 2011 Oct-Dec
TI  - Survey of ethics committee protocol approval letters: compliance with Schedule
      Y/ICMR guidelines 2006.
PG  - 214-6
AB  - A study was carried out to determine the extent to which ECs comply with format
      requirements given in guidelines and regulations. ECs were sent a written
      communication requesting them to permit investigators to study their approval
      letter for compliance with the ICMR Guidelines and Schedule Y using a
      pre-designed proforma. Of the 60 ECs approached, only 20 agreed to participate.
      Legal experts and social scientists were not present at the approval meetings of 
      most of the ECs. Only 7 ECs had a quorum according to Schedule Y Several ECs did 
      not state whether documents such as the clinical trial agreement and insurance
      policy were reviewed. Delays in sending approval letters could be shortened with 
      efficacious operating of ECs. There is a need to train EC members and create a
      better awareness of regulatory requirements. There is also a need to evolve a
      mechanism to monitor EC functioning.
FAU - Taur, Santosh R
AU  - Taur SR
AD  - Department of Clinical Pharmacology, Seth GS Medical College and KEM Hospital,
      Parel, Mumbai 400 012, India. dr.santoshtaur@gmail.com
FAU - Bavdekar, Sandeep B
AU  - Bavdekar SB
FAU - Thatte, Urmila M
AU  - Thatte UM
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - *Correspondence as Topic
MH  - *Ethics Committees, Research
MH  - *Guideline Adherence
MH  - *Guidelines as Topic
MH  - Humans
MH  - India
MH  - Retrospective Studies
EDAT- 2011/11/24 06:00
MHDA- 2011/12/27 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/27 06:00 [medline]
AID - 10.20529/IJME.2011.083 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2011 Oct-Dec;8(4):214-6. doi: 10.20529/IJME.2011.083.


PMID- 22106656
OWN - NLM
STAT- MEDLINE
DCOM- 20111226
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 8
IP  - 4
DP  - 2011 Oct-Dec
TI  - Institutional ethics committees: critical gaps.
PG  - 200-1
FAU - Thomas, George
AU  - Thomas G
LA  - eng
PT  - Editorial
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Ethics Committees, Research/*standards
MH  - *Guideline Adherence
MH  - *Guidelines as Topic
MH  - Humans
MH  - India
EDAT- 2011/11/24 06:00
MHDA- 2011/12/27 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/27 06:00 [medline]
AID - 10.20529/IJME.2011.080 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2011 Oct-Dec;8(4):200-1. doi: 10.20529/IJME.2011.080.


PMID- 22106646
OWN - NLM
STAT- MEDLINE
DCOM- 20111227
LR  - 20191210
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 8
IP  - 3
DP  - 2011 Jul-Sep
TI  - Supported and unsupported claims in medicinal drug advertisements in Indian
      medical journals.
PG  - 170-4
AB  - The study assessed 292 supported and unsupported claims in 102 medicinal drug
      advertisements across 15 Indian medical journals published in 2009. WHO ethical
      criteria for medicinal drug promotion were applied. None of the advertisements
      satisfied all the WHO criteria. Safe prescribing information on major adverse
      drug reactions, contraindications and warnings was provided in only 19
      advertisements. Of 292 drug claims, only 80 (27%) were supported with
      reference(s), of which only 7 (9%) claims were unambiguous, or well substantiated
      with references. 14 references quoted did not substantiate the claim and 15
      constituted weak scientific evidence. Superlatives like "tested" "trusted"
      "guarantees success" and "matchless safety" were used without evidence to
      substantiate such claims. Stronger enforcement mechanisms are necessary to ensure
      reliable drug information in pharmaceutical advertisements.
FAU - Dhanaraj, Ethiraj
AU  - Dhanaraj E
AD  - Department of Pharmacy Practice, National Institute of Pharmaceutical Education
      and Research, SAS Nagar, Punjab 160 062 India. dhanarajcrp@gmail.com
FAU - Nigam, Aditi
AU  - Nigam A
FAU - Bagani, Sanjay
AU  - Bagani S
FAU - Singh, Himmat
AU  - Singh H
FAU - Tiwari, Pramil
AU  - Tiwari P
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Advertising/*ethics
MH  - *Deception
MH  - Drug Industry/*ethics
MH  - Guideline Adherence/ethics
MH  - Humans
MH  - India
MH  - *Periodicals as Topic
EDAT- 2011/11/24 06:00
MHDA- 2011/12/28 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/28 06:00 [medline]
AID - 10.20529/IJME.2011.067 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2011 Jul-Sep;8(3):170-4. doi: 10.20529/IJME.2011.067.


PMID- 22106645
OWN - NLM
STAT- MEDLINE
DCOM- 20111227
LR  - 20191210
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 8
IP  - 3
DP  - 2011 Jul-Sep
TI  - Content audit of drug advertisements in Pakistan.
PG  - 167-9
AB  - A sample of 120 drug advertisements was drawn by nonprobability convenience
      sampling from among the stalls of 50 pharmaceutical companies participating in an
      exhibition in Karachi, Pakistan. 23 belonging to the NSAID drug group were
      selected and evaluated on whether they met guidelines for ethical advertisements 
      as laid down in the Drugs Act, 1976. Only 5 out of the 23 advertisements met at
      least 14 out of 16 criteria for ethical advertisements as given in the Drugs Act,
      1976.
FAU - Vakani, Farhan
AU  - Vakani F
AD  - Bioethics Unit, Aga Khan University, Stadium Road, PO Box 3500, Karachi,
      Pakistan. farhan.vakani@aku.edu
FAU - Naqv, Kashif
AU  - Naqv K
FAU - Amin, Almas
AU  - Amin A
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Advertising/*ethics
MH  - Drug Industry/*ethics
MH  - Ethical Review
MH  - Guideline Adherence/*ethics
MH  - Humans
MH  - Pakistan
EDAT- 2011/11/24 06:00
MHDA- 2011/12/28 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/28 06:00 [medline]
AID - 10.20529/IJME.2011.066 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2011 Jul-Sep;8(3):167-9. doi: 10.20529/IJME.2011.066.


PMID- 22106642
OWN - NLM
STAT- MEDLINE
DCOM- 20111227
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 8
IP  - 3
DP  - 2011 Jul-Sep
TI  - Bioethics governance in Israel: an expert regime.
PG  - 157-60
AB  - This paper provides an overview of bioethics governance in Israel through an
      analytical description of the legal framework for the interface between
      individuals and biomedical practices. There is no national agency with general
      oversight of bioethics policy and decision making, and the rules that apply to
      individual usage of biomedical technologies are laid down in a multitude of
      different statutes, regulations and administrative directives. Expert committees 
      play a central role in this regulatory system in two capacities: as governmental 
      advisory bodies that recommend policy; and as decision-making bodies that resolve
      conflicts around patients' rights or grant individual access to biomedical
      technologies. This decentralised system of governance through expert committees
      allows for adaptation to dynamic technological developments and flexibility in
      accommodating creative societal usage. At the same time the experts are the
      agents of the state's bio-power at the expense of personal autonomy and open
      public deliberation. The paper is part of a larger study investigating Israel's
      bioethics governance and its regime of experts, which includes an examination of 
      the normative level of regulation, and an analysis of the composition of the
      expert committees. Our findings suggest that Israel has a decentralised system of
      governance with piecemeal regulation that has established a bioethics
      technocracy, governed by the ministry of health and dominated by the medical
      profession. The present paper is confined to a description and discussion of the 
      legal framework of Israel's expert bioethics regime. Here, our major conclusion
      is that Israel has established a technocracy of official expert ethics
      committees, which controls life and death decisions.
FAU - Shalev, Carmel
AU  - Shalev C
AD  - Faculty of Law, Haifa University Israel. cshalev@012.net.il
FAU - Hashiloni-Dolev, Yael
AU  - Hashiloni-Dolev Y
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Biomedical Technology/*ethics
MH  - *Ethical Review/legislation & jurisprudence
MH  - Ethics Committees/legislation & jurisprudence/*organization & administration
MH  - Humans
MH  - Israel
MH  - *Public Policy
EDAT- 2011/11/24 06:00
MHDA- 2011/12/28 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/28 06:00 [medline]
AID - 10.20529/IJME.2011.063 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2011 Jul-Sep;8(3):157-60. doi: 10.20529/IJME.2011.063.


PMID- 22106641
OWN - NLM
STAT- MEDLINE
DCOM- 20111227
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 8
IP  - 3
DP  - 2011 Jul-Sep
TI  - Global summit of national ethics committees: an essential tool for international 
      dialogue and consensus-building.
PG  - 154-7
AB  - July 2010, important decisions were taken to ensure the continuity Held for the
      first time in 1996, the Global Summit of National of activities between the
      Summits. This article intends to briefly Ethics Committees (NECs) is a key
      platform for dialogue and retrace the history and analyse the role and
      functioning of the fostering consensus on ethical issues at a global level. At
      the Global Summit. It also discusses future challenges for international Eighth
      Global Summit meeting, which took place in Singapore in collaboration of NECs.
FAU - Bouesseau, Marie-Charlotte
AU  - Bouesseau MC
AD  - World Health Organization, Geneva Switzerland. bouesseaum@who.int
FAU - Reis, Andreas
AU  - Reis A
FAU - Ho, W Calvin
AU  - Ho WC
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - *Consensus Development Conferences as Topic
MH  - *Ethics Committees, Research
MH  - Humans
MH  - *International Cooperation
MH  - Organizational Objectives
EDAT- 2011/11/24 06:00
MHDA- 2011/12/28 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/28 06:00 [medline]
AID - 10.20529/IJME.2011.062 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2011 Jul-Sep;8(3):154-7. doi: 10.20529/IJME.2011.062.


PMID- 22106640
OWN - NLM
STAT- MEDLINE
DCOM- 20111227
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 8
IP  - 3
DP  - 2011 Jul-Sep
TI  - Competence of ethics committees in patient protection in clinical research.
PG  - 151-4
AB  - Research Ethics Committees (RECs) are responsible for the protection of patients'
      rights and wellbeing. In this paper, we describe the findings of a survey of
      ethics committee members in a south Indian state. 29 members of 11 RECs responded
      to a questionnaire of 56 questions on their knowledge of and attitudes towards
      ethics review and the practices of the RECs to which they belonged.
FAU - Nadig, Pratibha
AU  - Nadig P
AD  - Department of Pharmacology, Vydehi Institute of Medical Sciences and Research
      centre, Bangalore 560 056 India. drpratibhanadig@yahoo.co.in
FAU - Joshi, Medha
AU  - Joshi M
FAU - Uthappa, Aradhana
AU  - Uthappa A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - *Ethics Committees, Research
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - India
MH  - Male
MH  - Patient Rights/*ethics
MH  - *Professional Competence
EDAT- 2011/11/24 06:00
MHDA- 2011/12/28 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/28 06:00 [medline]
AID - 10.20529/IJME.2011.061 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2011 Jul-Sep;8(3):151-4. doi: 10.20529/IJME.2011.061.


PMID- 22106639
OWN - NLM
STAT- MEDLINE
DCOM- 20111227
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 8
IP  - 3
DP  - 2011 Jul-Sep
TI  - Institutionalisation of Bulgarian ethics committees: history and current status.
PG  - 148-51
AB  - This paper provides an overview of the institutionalisation of the ethics review 
      process in Bulgaria in accordance with the worldwide trend in establishment of
      ethics committees. Historical and current politico-legal changes influencing the 
      work of ethics committees are analysed. The paper focuses on ethics committees
      which review biomedical research involving humans, with an emphasis on their
      composition, functions, training of members, and decision-making processes.
      Recent positive changes addressing insufficient training of ethics
      committees'members are highlighted. Recommendations are made for enhancement of
      the ethics review process and improved transparency.
FAU - Krastev, Yordanka
AU  - Krastev Y
AD  - Centre for Primary Health Care and Equity, University of New South Wales, Sydney,
      NSW 2052 Australia. y.krastev@unsw.edu.au
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Bulgaria
MH  - Clinical Trials as Topic/ethics
MH  - Drug Evaluation/ethics
MH  - Education, Professional
MH  - Ethics Committees, Research/history/*organization & administration/trends
MH  - History, 20th Century
MH  - Human Experimentation/ethics
MH  - Humans
MH  - Multicenter Studies as Topic/ethics
EDAT- 2011/11/24 06:00
MHDA- 2011/12/28 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/28 06:00 [medline]
AID - 10.20529/IJME.2011.060 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2011 Jul-Sep;8(3):148-51. doi: 10.20529/IJME.2011.060.


PMID- 22106638
OWN - NLM
STAT- MEDLINE
DCOM- 20111227
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 8
IP  - 3
DP  - 2011 Jul-Sep
TI  - Towards local participation in the creation of ethical research guidelines.
PG  - 145-7
AB  - Research ethics committees are entrusted with implementing guidelines to protect 
      both scientists and human subjects of research from harm. These guidelines are
      often based on western contexts and may not resonate with the local moral
      traditions of the communities that they seek to protect. In this essay, we
      discuss how using principles of deliberative democracy with a "local derivation" 
      approach may help in the drafting and implementation of ethical guidelines for
      research that better serve society.
FAU - Blom, Erica
AU  - Blom E
AD  - University of Michigan, 734 Spring Street, Ann Arbor, MI 48103, USA.
      eblom@umich.edu
FAU - De Vries, Raymond
AU  - De Vries R
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - *Community Participation
MH  - *Cultural Competency
MH  - *Ethics, Research
MH  - *Guidelines as Topic
MH  - Humans
MH  - India
EDAT- 2011/11/24 06:00
MHDA- 2011/12/28 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/28 06:00 [medline]
AID - 10.20529/IJME.2011.059 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2011 Jul-Sep;8(3):145-7. doi: 10.20529/IJME.2011.059.


PMID- 22106637
OWN - NLM
STAT- MEDLINE
DCOM- 20111227
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 8
IP  - 3
DP  - 2011 Jul-Sep
TI  - The ethics of ethical expertise in science, medicine and healthcare policies.
PG  - 142-5
FAU - Schicktanz, Silke
AU  - Schicktanz S
AD  - Department of Medical Ethics and History of Medicine, University Medical Center, 
      Goettingen, Humboldtallee 36, D-37073 Goettingen Germany. gwdg.de' Freelance
      academic, Berlin GERMANY e-mail: mdusche@gmx.de. sschick@gwdg.de
FAU - Dusche, Michael
AU  - Dusche M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - *Ethics Committees
MH  - Ethics, Medical
MH  - Health Policy
MH  - Humans
MH  - India
MH  - *Professional Role
MH  - *Public Policy
MH  - Science/ethics
EDAT- 2011/11/24 06:00
MHDA- 2011/12/28 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/28 06:00 [medline]
AID - 10.20529/IJME.2011.058 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2011 Jul-Sep;8(3):142-5. doi: 10.20529/IJME.2011.058.


PMID- 22106636
OWN - NLM
STAT- MEDLINE
DCOM- 20111227
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 8
IP  - 3
DP  - 2011 Jul-Sep
TI  - Inclusion of ethics matters in the undergraduate medical curriculum.
PG  - 135-8
FAU - Anshu
AU  - Anshu
LA  - eng
PT  - Editorial
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Curriculum
MH  - *Education, Medical, Undergraduate
MH  - Ethics, Medical/*education
MH  - Humans
MH  - India
MH  - Program Development
EDAT- 2011/11/24 06:00
MHDA- 2011/12/28 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/28 06:00 [medline]
AID - 10.20529/IJME.2011.057 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2011 Jul-Sep;8(3):135-8. doi: 10.20529/IJME.2011.057.


PMID- 22106635
OWN - NLM
STAT- MEDLINE
DCOM- 20111227
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 8
IP  - 3
DP  - 2011 Jul-Sep
TI  - Can ethics committees address society's concerns about standards in research?
PG  - 134-5
FAU - Jesani, Amar
AU  - Jesani A
LA  - eng
PT  - Editorial
PT  - Introductory Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Ethics Committees, Research/*ethics/organization & administration
MH  - Humans
MH  - India
MH  - Information Dissemination/*ethics
MH  - *Social Control, Formal
EDAT- 2011/11/24 06:00
MHDA- 2011/12/28 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/28 06:00 [medline]
AID - 10.20529/IJME.2011.056 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2011 Jul-Sep;8(3):134-5. doi: 10.20529/IJME.2011.056.


PMID- 22106624
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111226
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 8
IP  - 2
DP  - 2011 Apr-Jun
TI  - How to teach ethics to those who need to learn.
PG  - 117-9
FAU - Ravi, Malvika
AU  - Ravi M
AD  - Department of Psychiatry, NIMHANS, Hosur Road, Bangalore 560 029 India.
      malvikaravi@gmail.com
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
CON - J Med Ethics. 2010 Dec;36(12):721-6. PMID: 21112935
EDAT- 2011/11/24 06:00
MHDA- 2011/11/24 06:01
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/11/24 06:01 [medline]
AID - 10.20529/IJME.2011.042 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2011 Apr-Jun;8(2):117-9. doi: 10.20529/IJME.2011.042.


PMID- 22106622
OWN - NLM
STAT- MEDLINE
DCOM- 20111226
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 8
IP  - 2
DP  - 2011 Apr-Jun
TI  - Living unrelated kidney donors: ethical aspects of living kidney donation in
      Brazil.
PG  - 112-4
AB  - Brazil has established the largest public kidney transplantation system in the
      world .46.2% of transplants in 2008 came from living donors. The vast majority of
      these involved relatives of the recipient; less than 8% came from unrelated
      donors. In 2008, Brazil's health minister proposed banning unrelated donors in
      kidney transplantation. A large number of the over 35,000 Brazilians on the
      waiting list for a kidney would be denied a transplant without the use of
      unrelated donors. Brazilian culture has a unique feature, the "informal family", 
      that is not legally recognised as a "family entity and is bound by affection
      rather than genetic or legal ties. It is vital that Brazil establishes a
      regulated, standardised, and ethical system of organ procurement; creates
      awareness about transplantation in physicians and the public; upgrades facilities
      and standardises medical care, and enforces legislation for transplantation.
      However, outlawing the use of unrelated donors would result in injustice for many
      patients who seek kidneys.
FAU - Ferreira, Gustavo Fernandes
AU  - Ferreira GF
AD  - Transplant Renal Unit, Medical School University of Sao Paulo, Brazil.
      gustavofferreira@gmail.com
FAU - Guedes, Clarissa Diniz
AU  - Guedes CD
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Brazil
MH  - Health Care Sector/ethics/legislation & jurisprudence
MH  - Humans
MH  - Kidney Transplantation/*ethics
MH  - Living Donors/*ethics/*legislation & jurisprudence
MH  - Tissue and Organ Procurement/*ethics/*legislation & jurisprudence
EDAT- 2011/11/24 06:00
MHDA- 2011/12/27 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/27 06:00 [medline]
AID - 10.20529/IJME.2011.040 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2011 Apr-Jun;8(2):112-4. doi: 10.20529/IJME.2011.040.


PMID- 22106620
OWN - NLM
STAT- MEDLINE
DCOM- 20111226
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 8
IP  - 2
DP  - 2011 Apr-Jun
TI  - Ethical aspects of the Revised National Tuberculosis Control Programme.
PG  - 102-6
AB  - This paper identifies some ethical concerns regarding the Revised National
      Tuberculosis Control Programme (RNTCP). Only 10% of those with chest symptoms
      visiting public health facilities get specific treatment as they are diagnosed
      with TB. The remaining 90% who suffer from non-TB diseases are not given
      scientific treatment. This compartmental approach denies treatment to millions of
      people with chest symptoms. It has also eroded the popularity of public health
      facilities. Second, though 87% of those diagnosed on the basis of x-ray alone are
      unlikely to have TB, such unethical wrong diagnoses continue to be carried out
      under the TB programme. Still worse, the RNTCP's expectation that only half of TB
      cases should be smear positive effectively permits up to 50% of diagnoses to be
      wrong. The actual extent of wrong diagnosis is even higher as the majority of
      people with chest symptoms first visit private health facilities which base their
      diagnosis almost exclusively on radiological examination. Third, though 25% to
      33% of TB cases get cured spontaneously, and at least two-thirds were cured even 
      with incomplete treatment, the RNTCP insists on full treatment for all TB cases. 
      This over-treatment is unethical, wasteful and also tantamount to scientific
      dishonesty. Studies to identify different categories of cases (those needing full
      treatment, short treatment or no treatment) have not been attempted. The
      introduction (under the RNTCP) of the "success rate"in preference to the well
      recognised "cure rate" was unethical and unwarranted. "Crying wolf" over Multiple
      Drug Resistant (MDR) TB to justify DOTS when there is no apparent alarming
      increase in the incidence of initial MDR tuberculosis cases is also questionable.
      Other ethical concerns about the RNTCP include the irrational choice of districts
      leading to exclusion of those that need the services most; exclusion of diagnosed
      patients from the DOTS scheme, and exclusion from treatment on non-medical
      grounds. Such exclusions can be up to 58% of TB cases.
FAU - Nair, S S
AU  - Nair SS
AD  - Ministry of Health and Family Welfare, Government of India, 618,3rd Cross, 3rd
      Block, Koramangala, Bangalore 560 034 India. forte.nair@gmail.com
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
RN  - 0 (Antitubercular Agents)
SB  - IM
MH  - Antitubercular Agents/therapeutic use
MH  - Communicable Disease Control/organization & administration
MH  - Diagnostic Errors/ethics
MH  - Directly Observed Therapy/ethics
MH  - Humans
MH  - Inappropriate Prescribing/ethics
MH  - India
MH  - National Health Programs/*ethics/organization & administration
MH  - *Needs Assessment
MH  - Quality of Health Care/*ethics/organization & administration
MH  - Tuberculosis/diagnosis/drug therapy/*prevention & control
MH  - Tuberculosis, Multidrug-Resistant/drug therapy/prevention & control
EDAT- 2011/11/24 06:00
MHDA- 2011/12/27 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/27 06:00 [medline]
AID - 10.20529/IJME.2011.038 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2011 Apr-Jun;8(2):102-6. doi: 10.20529/IJME.2011.038.


PMID- 22106619
OWN - NLM
STAT- MEDLINE
DCOM- 20111226
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 8
IP  - 2
DP  - 2011 Apr-Jun
TI  - Orthopaedic surgeons and the device industry: skeletons in the closet.
PG  - 97-102
AB  - The relationship between orthopaedic surgeons and the device industry is one that
      is mutually beneficial and productive. However there are skeletons in the closet.
      The financial implications of this relationship have come under intense scrutiny.
      The sponsorships and the financial benefits of this symbiotic relationship have
      been found to cross the boundaries considered acceptable to ethical practice of
      the profession. In India, the ethical transgressions resulting from unhealthy
      associations between the orthopaedic surgeon and the industry have yet to be
      given due importance. Adequate rules and regulations are yet to be enforced and
      self-regulation is practically non-existent. It is essential to deal with the
      problem and potential implications that can arise from this kind of misconduct at
      the organisational level and enforce them for compliance.
FAU - Poduval, Murali
AU  - Poduval M
AD  - Faculty of Medicine, Department of Orthopedics, AIMST University, Kedah Darul
      Alam, Malaysia. muralipoduval@gmail.com
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - *Conflict of Interest
MH  - Health Care Sector/*ethics
MH  - Humans
MH  - India
MH  - Orthopedic Equipment
MH  - Orthopedics/*ethics
MH  - Professional Autonomy
MH  - *Professional Misconduct
MH  - Prostheses and Implants
MH  - United States
EDAT- 2011/11/24 06:00
MHDA- 2011/12/27 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/27 06:00 [medline]
AID - 10.20529/IJME.2011.037 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2011 Apr-Jun;8(2):97-102. doi: 10.20529/IJME.2011.037.


PMID- 22106614
OWN - NLM
STAT- MEDLINE
DCOM- 20111226
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 8
IP  - 2
DP  - 2011 Apr-Jun
TI  - SEARCH's HBNC trial: towards a broader debate on the ethics of social
      intervention research.
PG  - 78-85
AB  - The SEARCH home-based neonatal care (HBNC) trial generated a heated debate
      amongst health activists, researchers and demographers in India upon its
      publication in the Lancet in 1999. More than a decade after the Lancet article, a
      new debate has been sparked, this time on the ethics of the study. Against this
      backdrop, we identify three key questions which require in-depth discussion.
      First, was the choice of the study design (cluster nonrandomised control trial), 
      appropriate given the circumstances relating both to the study site and the
      locale? Second, was it ethical not to offer any intervention to the control units
      given that a known treatment existed? Third, do contemporary research ethics
      guidelines satisfactorily address all the ethical issues related to the study
      design? This paper examines the first question. We draw three main conclusions
      from this critical appraisal of the HBNC trial. First, the study design of the
      trial is motivated by the paradigm of evidence-based programmes and policy
      formulation. Second, generally speaking, the HBNC study design passes the
      internal and external validity tests but raises important ethical questions.
      Third, these questions transcend the HBNC trial to apply to many other social and
      health interventions studies; as such, the HBNC trial should be studied as a
      paradigmatic case.
FAU - Bandewar, Sunita V S
AU  - Bandewar SV
AD  - University of Toronto,Toronto, Canada. sunita.bandewar@utoronto.ca
FAU - John, T A
AU  - John TA
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Clinical Trials as Topic/*ethics
MH  - Health Services Research/*ethics
MH  - *Home Care Services
MH  - Humans
MH  - India/epidemiology
MH  - Infant Mortality
MH  - Infant, Newborn
MH  - *Postnatal Care
MH  - *Research Design
MH  - Rural Health Services
MH  - Vulnerable Populations
EDAT- 2011/11/24 06:00
MHDA- 2011/12/27 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/27 06:00 [medline]
AID - 10.20529/IJME.2011.032 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2011 Apr-Jun;8(2):78-85. doi: 10.20529/IJME.2011.032.


PMID- 22106601
OWN - NLM
STAT- MEDLINE
DCOM- 20111223
LR  - 20181201
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 8
IP  - 1
DP  - 2011 Jan-Mar
TI  - Health systems research and the Gadchiroli debate: a plea for universal and
      equitable ethics.
PG  - 47-8
FAU - Prashanth, N S
AU  - Prashanth NS
AD  - Institute of Public Health, #250, 2C Main, 2C Cross, Girinagar 1st Phase,
      Bangalore 560 085, India. prashanthns@iphindia.org
FAU - Bhojani, Upendra
AU  - Bhojani U
FAU - Soors, Werner
AU  - Soors W
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
CON - Indian J Med Ethics. 2010 Jan-Mar;7(1):12-4. PMID: 20166288
MH  - Humans
MH  - Randomized Controlled Trials as Topic/*ethics
MH  - Sepsis/*therapy
EDAT- 2011/11/24 06:00
MHDA- 2011/12/24 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/24 06:00 [medline]
AID - 10.20529/IJME.2011.016 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2011 Jan-Mar;8(1):47-8. doi: 10.20529/IJME.2011.016.


PMID- 22106599
OWN - NLM
STAT- MEDLINE
DCOM- 20111223
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 8
IP  - 1
DP  - 2011 Jan-Mar
TI  - Bioethics and transnational medical travel: India,"medical tourism," and the
      globalisation of healthcare.
PG  - 42-4
AB  - Health-related travel, also referred to as "medical tourism" is historically
      well-known. Its emerging contemporary form suggests the development of a form of 
      globalised for-profit healthcare. Medical tourism to India, the focus of a recent
      conference in Canada, provides an example of the globalisation of healthcare. By 
      positioning itself as a low-cost, high-tech, fast-access and high-quality
      healthcare destination country, India offers healthcare to medical travellers who
      are frustrated with waiting lists and the limited availability of some procedures
      in Canada. Although patients have the right to travel and seek care at
      international medical facilities, there are a number of dimensions of medical
      tourism that are disturbing. The diversion of public investments in healthcare to
      the private sector, in order to serve medical travellers, perversely transfers
      public resources to international patients at a time when the Indian public
      healthcare system fails to provide primary healthcare to its own citizens.
      Further, little is known about patient safety and quality care in transnational
      medical travel. Countries that are departure points as well as destination
      countries need to carefully explore the ethical, social, cultural, and economic
      consequences of the growing phenomenon of for-profit international medical
      travel.
FAU - Runnels, Vivien
AU  - Runnels V
AD  - Globalisation and Health Equity Research Unit, Institute of Population Health,
      University of Ottawa, 216-1 Stewart Street, Ottawa, Ontario K1N 6N5, Canada.
      vrunnels@uottawa.ca
FAU - Turner, Leigh
AU  - Turner L
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Canada
MH  - Health Care Rationing/ethics
MH  - Healthcare Disparities/*ethics
MH  - Humans
MH  - India
MH  - *Internationality
MH  - Medical Tourism/*ethics
EDAT- 2011/11/24 06:00
MHDA- 2011/12/24 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/24 06:00 [medline]
AID - 10.20529/IJME.2011.014 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2011 Jan-Mar;8(1):42-4. doi: 10.20529/IJME.2011.014.


PMID- 22106597
OWN - NLM
STAT- MEDLINE
DCOM- 20111223
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 8
IP  - 1
DP  - 2011 Jan-Mar
TI  - Survey of "instructions to authors" of Indian medical journals for reporting of
      ethics and authorship criteria.
PG  - 36-8
AB  - This study looked at information on ethics reporting and authorship in the
      "instructions to authors" section of Indian medical journals. Instructions to
      authors in 59 Indian medical journals were examined for guidance on ethics
      reporting and authorship. Guidance regarding ethics was mentioned in 43 (72.8%)
      journals; assent from minors was mentioned in 9 (15.2%) journals; approval from
      an animal ethics committee was mentioned in 10 (16.9%) journals; authorship
      criteria were mentioned in 38 (64.5%) journals. Authorship criteria according to 
      the International Committee of Medical Journal Editors were mentioned in 35
      (59.3%) journals. Guidance regarding contributors' details was mentioned in 30
      (50.8%) journals. These findings suggest that many editors of Indian medical
      journals must upgrade their instructions to authors to include ethical
      requirements.
FAU - Jaykaran
AU  - Jaykaran
AD  - Department of Pharmacology, Government Medical College, Surat 395 001, India.
      drjaykaran@yahoo.co.in
FAU - Yadav, Preeti
AU  - Yadav P
FAU - Chavda, Nilesh
AU  - Chavda N
FAU - Kantharia, N D
AU  - Kantharia ND
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - *Authorship
MH  - *Bibliometrics
MH  - *Editorial Policies
MH  - *Ethics, Research
MH  - Humans
MH  - India
MH  - Periodicals as Topic/*ethics
EDAT- 2011/11/24 06:00
MHDA- 2011/12/24 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/24 06:00 [medline]
AID - 10.20529/IJME.2011.012 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2011 Jan-Mar;8(1):36-8. doi: 10.20529/IJME.2011.012.


PMID- 22106596
OWN - NLM
STAT- MEDLINE
DCOM- 20111223
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 8
IP  - 1
DP  - 2011 Jan-Mar
TI  - Ethics of transparency in research reports.
PG  - 31-6
AB  - Transparency in research methods and results is now widely seen as an imperative 
      if the healthcare and research enterprise is to be truly successful. A
      patient-centred focus in the conduct of clinical care includes its safety,
      effectiveness, efficiency, equity, and timeliness. Innovative ways are being
      developed to understand, disseminate, and rapidly apply the best evidence to care
      delivery. In this article, we demonstrate the use of simple and appropriate
      statistics in research reports that should help healthcare providers apply
      knowledge to practice by making it easier for them to understand clinical
      medicine.
FAU - Selvan, Mano S
AU  - Selvan MS
AD  - Memorial Hermann Healthcare System, Houston, Texas 77074, USA.
      Mano.Selvan@memorialhermann.org
FAU - Subbian, Saravana
AU  - Subbian S
FAU - Cantor, Scott B
AU  - Cantor SB
FAU - Rodriguez, Alma
AU  - Rodriguez A
FAU - Smith, Martin L
AU  - Smith ML
FAU - Walsh, Garrett L
AU  - Walsh GL
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Cost-Benefit Analysis
MH  - Data Interpretation, Statistical
MH  - Drug Evaluation/statistics & numerical data
MH  - Evidence-Based Medicine
MH  - Humans
MH  - Information Dissemination/*ethics
MH  - *Research Report
EDAT- 2011/11/24 06:00
MHDA- 2011/12/24 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/24 06:00 [medline]
AID - 10.20529/IJME.2011.011 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2011 Jan-Mar;8(1):31-6. doi: 10.20529/IJME.2011.011.


PMID- 22106595
OWN - NLM
STAT- MEDLINE
DCOM- 20111223
LR  - 20220408
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 8
IP  - 1
DP  - 2011 Jan-Mar
TI  - Private health insurance and access to healthcare.
PG  - 28-30
AB  - The health insurance business in India has seen a growth of over 25% per annum in
      the last few years with the expansion of the private health insurance sector. The
      premium incomes of health insurance have crossed the Rs 8,000 crore mark with the
      share of private companies increasing to over 41%. This is despite the fact that 
      from the perspective of patients, health insurance is not a good deal, especially
      when they need it most. This raises a number of ethical issues regarding how the 
      health insurance business runs and how medical practice adjusts to it for
      profiteering. This article uses the personal experience of the author to argue
      that health insurance in an unregulated environment can only lead to unethical
      practices, further victimising the patient. Further, publicly financed healthcare
      which operates in an environment regulating both public and private healthcare
      provisioning is the only way to assure access to ethical and equitable healthcare
      to people.
FAU - Duggal, Ravi
AU  - Duggal R
AD  - International Budget Partnership, People's Health Movement, India.
      rduggal57@gmail.com
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
CIN - Indian J Med Ethics. 2011 Oct-Dec;8(4):261. PMID: 22106675
MH  - Fees and Charges
MH  - Health Services Accessibility/*ethics
MH  - Health Services Needs and Demand
MH  - Humans
MH  - India
MH  - Insurance Benefits
MH  - Insurance, Health/*ethics
MH  - Private Sector/*ethics
EDAT- 2011/11/24 06:00
MHDA- 2011/12/24 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/24 06:00 [medline]
AID - 10.20529/IJME.2011.010 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2011 Jan-Mar;8(1):28-30. doi: 10.20529/IJME.2011.010.


PMID- 22106594
OWN - NLM
STAT- MEDLINE
DCOM- 20111223
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 8
IP  - 1
DP  - 2011 Jan-Mar
TI  - Ethical questions regarding health insurance in India.
PG  - 23-7
AB  - Improved health and healthcare are of vital concern to the welfare of Indian
      society. The nascent health insurance system of the country is experiencing an
      explosive expansion and various models of health insurance provision are under
      trial by different agencies. Since the country has been relatively late in
      introducing health insurance, it can study the effects of different systems of
      healthcare and insurance and develop a system of health coverage which addresses 
      the unique social character of our country as well as the ethical questions of
      comprehensiveness and inclusion. This article seeks to explore these issues in
      detail.
FAU - Mathur, Vineesh
AU  - Mathur V
AD  - Orthopaedics, Medanta, The Medicity, Gurgaon 122 001 Haryana, India.
      drvmathur@gmail.com
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
CIN - Indian J Med Ethics. 2011 Oct-Dec;8(4):261. PMID: 22106675
MH  - Government Regulation
MH  - Humans
MH  - India
MH  - Insurance Coverage/*ethics
MH  - Insurance, Health/*ethics/legislation & jurisprudence
MH  - National Health Programs
EDAT- 2011/11/24 06:00
MHDA- 2011/12/24 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/24 06:00 [medline]
AID - 10.20529/IJME.2011.009 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2011 Jan-Mar;8(1):23-7. doi: 10.20529/IJME.2011.009.


PMID- 22106592
OWN - NLM
STAT- MEDLINE
DCOM- 20111223
LR  - 20181201
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 8
IP  - 1
DP  - 2011 Jan-Mar
TI  - Ethics, equity and genocide.
PG  - 12-5
FAU - Sen, Binayak
AU  - Sen B
AD  - Medico Friend Circle, People's Union for Civil Liberties and Christian Medical
      College, Vellore, India.
LA  - eng
PT  - Address
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Biomedical Research/ethics
MH  - Comorbidity
MH  - Food Supply/ethics/legislation & jurisprudence
MH  - *Health Policy
MH  - *Health Status Disparities
MH  - Human Rights Abuses/*ethics/legislation & jurisprudence
MH  - Humans
MH  - India/epidemiology
MH  - Malnutrition/*epidemiology/therapy
MH  - Tuberculosis/*epidemiology/therapy
EDAT- 2011/11/24 06:00
MHDA- 2011/12/24 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/24 06:00 [medline]
AID - 10.20529/IJME.2011.004 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2011 Jan-Mar;8(1):12-5. doi: 10.20529/IJME.2011.004.


PMID- 22106591
OWN - NLM
STAT- MEDLINE
DCOM- 20111223
LR  - 20181201
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 8
IP  - 1
DP  - 2011 Jan-Mar
TI  - Ethics, equity and justice: a view from the belly of the beast.
PG  - 9-12
FAU - Nagral, Sanjay
AU  - Nagral S
AD  - Department of Surgical Gastroenterology, Jaslok Hospital and Research Centre, GD 
      Deshmukh Marg, Mumbai 400 026, India. sanjay.nagral@gmail.com
LA  - eng
PT  - Address
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Delivery of Health Care/*ethics/*trends
MH  - *Ethics, Medical
MH  - Humans
MH  - India
MH  - *Social Change
MH  - *Social Justice
EDAT- 2011/11/24 06:00
MHDA- 2011/12/24 06:00
CRDT- 2011/11/24 06:00
PHST- 2011/11/24 06:00 [entrez]
PHST- 2011/11/24 06:00 [pubmed]
PHST- 2011/12/24 06:00 [medline]
AID - 10.20529/IJME.2011.003 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2011 Jan-Mar;8(1):9-12. doi: 10.20529/IJME.2011.003.


PMID- 22106388
OWN - NLM
STAT- MEDLINE
DCOM- 20120404
LR  - 20111122
IS  - 1943-5657 (Electronic)
IS  - 0033-8397 (Linking)
VI  - 83
IP  - 2
DP  - 2011 Nov-Dec
TI  - Academic dishonesty and unprofessional behavior.
PG  - 133-40
AB  - PURPOSE: To investigate differences in radiologic science student and faculty
      perceptions of academic dishonesty and unprofessional behavior. METHODS:
      Radiologic science faculty and students were questioned about their perceptions
      of academic dishonesty and unprofessional behavior using ethical scenarios in an 
      electronic survey format. RESULTS: Significant differences occurred between
      faculty and student values regarding the seriousness of cheating and
      unprofessional behaviors. Faculty viewed cheating and unprofessional behaviors as
      more serious than students. Faculty and student self-reports of cheating behavior
      demonstrated no significant differences; however, significant differences existed
      in self-reported incidences of unprofessional behavior. CONCLUSION: Faculty and
      students differed in their values and participation related to cheating and
      unprofessional behaviors. Efforts should be directed toward bridging the gap
      between faculty and student perceptions.
CI  - (c)2011 by the American Society of Radiologic Technologists.
FAU - Aaron, Laura
AU  - Aaron L
AD  - Radiologic Sciences Program, Northwestern State University, Shreveport,
      Louisiana, USA.
FAU - Simmons, Pamela
AU  - Simmons P
FAU - Graham-Webb, Diane
AU  - Graham-Webb D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Radiol Technol
JT  - Radiologic technology
JID - 0401256
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Faculty/*statistics & numerical data
MH  - Humans
MH  - Professional Misconduct/*ethics/*statistics & numerical data
MH  - Radiology/*ethics/*statistics & numerical data
MH  - Students/*statistics & numerical data
MH  - United States
MH  - Universities/statistics & numerical data
EDAT- 2011/11/23 06:00
MHDA- 2012/04/05 06:00
CRDT- 2011/11/23 06:00
PHST- 2011/11/23 06:00 [entrez]
PHST- 2011/11/23 06:00 [pubmed]
PHST- 2012/04/05 06:00 [medline]
AID - 83/2/133 [pii]
PST - ppublish
SO  - Radiol Technol. 2011 Nov-Dec;83(2):133-40.


PMID- 22106357
OWN - NLM
STAT- MEDLINE
DCOM- 20120228
LR  - 20220410
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 262
IP  - 1
DP  - 2012 Jan
TI  - No benefit for consensus double reading at baseline screening for lung cancer
      with the use of semiautomated volumetry software.
PG  - 320-6
LID - 10.1148/radiol.11102289 [doi]
AB  - PURPOSE: To retrospectively evaluate the performance of consensus double reading 
      compared with single reading at baseline screening of a lung cancer computed
      tomography (CT) screening trial. MATERIALS AND METHODS: The study was approved by
      the Dutch Minister of Health and ethical committees. Written informed consent was
      obtained from all participants. The benefit of consensus double reading was
      expressed by the percentage change in cancer detection rate, recall rate, number 
      of additional nodules detected, and change in sensitivity and specificity in 7557
      participants. The reference standard was a retrospective analysis of the serial
      CT scans performed in participants diagnosed with lung cancer during a 2-year
      period after baseline. Semiautomated volumetric software was used for nodule
      evaluation. McNemar tests were performed to test statistical significance. In
      addition, sensitivity, specificity, positive predictive value (PPV), and negative
      predictive value (NPV) were calculated and 95% confidence intervals (CIs)
      constructed. RESULTS: Seventy-four cases of lung cancer were qualified as
      detectable at baseline. Compared with single reading, consensus double reading
      did not increase the cancer detection rate (2.7%; 95% CI: -1.0%, 6.4%; P = .50)
      or change the recall rate (20.6% vs 20.8%, P = .28), but led to the detection of 
      19.0% (1635 of 8623; 95% CI: 18.0%, 19.9%, P < .01) more nodules. The
      sensitivity, specificity, PPV, and NPV were 95.9% (71 of 74), 80.2% (6001 of
      7483), 4.6% (71 of 1553) and 99.9% (6001 of 6004) for single reading and 98.6%
      (73 of 74), 80.0% (1497 of 7483), 4.6% (73 of 1570), and 99.9% (5986 of 5987) for
      consensus double reading, respectively. CONCLUSION: There is no statistically
      significant benefit for consensus double reading at baseline screening for lung
      cancer with the use of a nodule management strategy based solely on semiautomated
      volumetry.
CI  - (c) RSNA, 2011.
FAU - Wang, Ying
AU  - Wang Y
AD  - Department of Radiology, University Medical Center Groningen, Hanzeplein 1, 9700 
      RB Groningen, the Netherlands.
FAU - van Klaveren, Rob J
AU  - van Klaveren RJ
FAU - de Bock, Geertruida H
AU  - de Bock GH
FAU - Zhao, Yingru
AU  - Zhao Y
FAU - Vernhout, Rene
AU  - Vernhout R
FAU - Leusveld, Anne
AU  - Leusveld A
FAU - Scholten, Ernst
AU  - Scholten E
FAU - Verschakelen, Johny
AU  - Verschakelen J
FAU - Mali, Willem
AU  - Mali W
FAU - de Koning, Harry
AU  - de Koning H
FAU - Oudkerk, Matthijs
AU  - Oudkerk M
LA  - eng
PT  - Journal Article
DEP - 20111121
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Belgium
MH  - Confidence Intervals
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/*diagnostic imaging
MH  - Male
MH  - Middle Aged
MH  - Netherlands
MH  - *Pattern Recognition, Automated
MH  - Predictive Value of Tests
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - *Software
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2011/11/23 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/11/23 06:00
PHST- 2011/11/23 06:00 [entrez]
PHST- 2011/11/23 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - radiol.11102289 [pii]
AID - 10.1148/radiol.11102289 [doi]
PST - ppublish
SO  - Radiology. 2012 Jan;262(1):320-6. doi: 10.1148/radiol.11102289. Epub 2011 Nov 21.


PMID- 22105731
OWN - NLM
STAT- MEDLINE
DCOM- 20120403
LR  - 20111122
IS  - 1121-421X (Print)
IS  - 1121-421X (Linking)
VI  - 57
IP  - 4
DP  - 2011 Dec
TI  - Should a physician interpret a medical study improperly performed by a nurse or
      technician, such as capsule endoscopy performed on a wrong patient? A reasonable 
      solution to a medicolegal dilemma.
PG  - 427-32
AB  - Improper performance by a nurse of a medical study/procedure (e.g., video capsule
      endoscopy performed on a wrong patient) raises novel, previously unexplored
      questions regarding: 1) whether the study should subsequently be interpreted; 2) 
      which physician should interpret the study; and 3) whether study interpretation
      requires another informed consent due to the extraordinary circumstances. Two
      such cases are reported. First, the Chief of Gastroenterology (GI) contacted the 
      hospital ethics committee regarding procedure interpretation after the wrong
      patient underwent video capsule endoscopy by a nurse. The committee recommended
      to inform and apologize to the patient about the nursing error, to not charge for
      this study, and to interpret the study, likewise without charge, provided that a 
      new informed consent was obtained that included discussion of the small potential
      patient benefit of study interpretation in this circumstance. These
      recommendations were followed. Study interpretation revealed a 3 mm wide
      characteristic angiodysplasia in the distal jejunum. Endoscopic therapy was not
      performed due to the small lesion size, and absence of gastrointestinal bleeding 
      or significant anemia. Second, the Chief of GI was informed of an esophageal
      manometry performed for chronic dysphagia that had not been interpreted for 7
      months due to its being performed by a nurse without any arrangement for a
      gastroenterologist to interpret the study. The referring gastroenterologist
      lacked training or privileges in esophageal manometry. The Chief of GI arranged
      for a motility expert to interpret the study. The study was read as technically
      inadequate because the nurse had been unable to intubate the stomach and the
      referring gastroenterologist had declined to assist in this difficult intubation.
      The motility expert noted that had he been involved earlier in the case he would 
      have himself attempted gastric intubation. In conclusion, a reasonable approach
      to a medical study improperly performed by a nurse includes: 1) inform and
      apologize to the patient about the error; 2) obtain informed consent for study
      interpretation, and 3) interpret the study at no charge. Consultation with an
      institutional Ethics Committee is advisable. An interpreting physician should be 
      identified at the time of scheduling a medical study. Although illustrated for GI
      studies, these recommendations pertain to studies performed by nurses or
      technicians in numerous medical fields, such as echocardiograms or pulmonary
      function tests.
FAU - Cappell, M S
AU  - Cappell MS
AD  - Division of Gastroenterology, William Beaumont Hospital, Royal Oak, MI 48073,
      USA. mscappell@yahoo.com
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Italy
TA  - Minerva Gastroenterol Dietol
JT  - Minerva gastroenterologica e dietologica
JID - 9109791
SB  - IM
MH  - Aged
MH  - Algorithms
MH  - *Capsule Endoscopy
MH  - Female
MH  - Humans
MH  - *Liability, Legal
MH  - Male
MH  - *Medical Errors
MH  - *Nurses
MH  - *Physicians
EDAT- 2011/11/23 06:00
MHDA- 2012/04/04 06:00
CRDT- 2011/11/23 06:00
PHST- 2011/11/23 06:00 [entrez]
PHST- 2011/11/23 06:00 [pubmed]
PHST- 2012/04/04 06:00 [medline]
AID - R08111915 [pii]
PST - ppublish
SO  - Minerva Gastroenterol Dietol. 2011 Dec;57(4):427-32.


PMID- 22105272
OWN - NLM
STAT- MEDLINE
DCOM- 20120913
LR  - 20210107
IS  - 1873-233X (Electronic)
IS  - 0029-7844 (Linking)
VI  - 118
IP  - 6
DP  - 2011 Dec
TI  - Informed consent and the use of transvaginal synthetic mesh.
PG  - 1409-1416
LID - 10.1097/AOG.0b013e318234da51 [doi]
AB  - In 2008 and again in July of this year, the U.S. Food and Drug Administration
      (FDA) issued safety communications regarding the use of transvaginally placed
      surgical mesh. These FDA communications have been the subject of much discussion 
      in the literature. One issue raised by these communications and in the medical
      literature is the matter of informed consent. Informed consent is an established 
      bioethical principle in modern health care, but it is evolving. The legal
      interpretations of informed consent are also in flux. A review of contemporary
      ethical and legal elements of informed consent is presented as it relates to the 
      use of medical innovation, with a focus on transvaginally placed surgical mesh.
FAU - Whiteside, James L
AU  - Whiteside JL
AD  - From the Department of Obstetrics and Gynecology, Dartmouth Medical School,
      Lebanon, New Hampshire.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Obstet Gynecol
JT  - Obstetrics and gynecology
JID - 0401101
SB  - IM
MH  - Bioethical Issues
MH  - Disclosure/standards
MH  - Female
MH  - Gynecologic Surgical Procedures/*ethics/legislation & jurisprudence
MH  - Humans
MH  - *Informed Consent
MH  - Pelvic Organ Prolapse/*surgery
MH  - *Surgical Mesh
EDAT- 2011/11/23 06:00
MHDA- 2012/09/14 06:00
CRDT- 2011/11/23 06:00
PHST- 2011/11/23 06:00 [entrez]
PHST- 2011/11/23 06:00 [pubmed]
PHST- 2012/09/14 06:00 [medline]
AID - 10.1097/AOG.0b013e318234da51 [doi]
AID - 00006250-201112000-00028 [pii]
PST - ppublish
SO  - Obstet Gynecol. 2011 Dec;118(6):1409-1416. doi: 10.1097/AOG.0b013e318234da51.


PMID- 22105162
OWN - NLM
STAT- MEDLINE
DCOM- 20130109
LR  - 20211021
IS  - 1433-7339 (Electronic)
IS  - 0941-4355 (Linking)
VI  - 20
IP  - 9
DP  - 2012 Sep
TI  - Palliative care quality indicators in Italy. What do we evaluate?
PG  - 1983-9
LID - 10.1007/s00520-011-1301-y [doi]
AB  - PURPOSE: In recent years, the number of palliative service providers has
      increased significantly. This expansion necessitates an evaluation in order to
      provide the basis for quality improvement of the care. Policymakers, managers of 
      palliative care programs, and others committed to the improvement of end-of-life 
      care need methods and criteria to measure and evaluate the care delivered. As
      quality measurement is expensive and difficult to undertake, it is fundamental
      that quality measures evaluate the right things. Quality evaluation in Italy is
      supported by health authorities who have developed some indicators of palliative 
      care. The aims of this study were to give an overview of these indicators.
      METHODS: We analyzed all palliative care indicators developed by Italian national
      authorities from 2000 to the present. These indicators have been divided into
      three different levels of analysis (structure, process, and outcome).
      Subsequently, two reviewers have independently compared their degree of
      concordance with domains, and guidelines developed by the NCP for palliative care
      and after careful discussion an expert panel has elaborated a final consensus
      document. RESULTS: Most of the quality indicators analyzed deal with the
      structure and process of palliative care, however they miss outcomes and do not
      cover domains mainly concerned with spiritual, ethical, cultural, or existential 
      aspects of care. CONCLUSIONS: More attention should be paid to the development of
      outcome indicators of palliative care. The attempt to identify a group of
      indicators which cover every domain of palliative care represents a challenge for
      the future in terms of finding new cognitive models more oriented toward
      subjectivity.
FAU - D'Angelo, Daniela
AU  - D'Angelo D
AD  - School of Nursing, University Tor Vergata, Rome, Italy. d.angelo@med.uniroma2.it
FAU - Mastroianni, Chiara
AU  - Mastroianni C
FAU - Vellone, Ercole
AU  - Vellone E
FAU - Alvaro, Rosaria
AU  - Alvaro R
FAU - Casale, Giuseppe
AU  - Casale G
FAU - Latina, Roberto
AU  - Latina R
FAU - De Marinis, Maria Grazia
AU  - De Marinis MG
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20111122
PL  - Germany
TA  - Support Care Cancer
JT  - Supportive care in cancer : official journal of the Multinational Association of 
      Supportive Care in Cancer
JID - 9302957
SB  - IM
MH  - Humans
MH  - Italy
MH  - Palliative Care/*standards
MH  - *Quality Indicators, Health Care
MH  - Terminal Care
EDAT- 2011/11/23 06:00
MHDA- 2013/01/10 06:00
CRDT- 2011/11/23 06:00
PHST- 2011/03/14 00:00 [received]
PHST- 2011/10/25 00:00 [accepted]
PHST- 2011/11/23 06:00 [entrez]
PHST- 2011/11/23 06:00 [pubmed]
PHST- 2013/01/10 06:00 [medline]
AID - 10.1007/s00520-011-1301-y [doi]
PST - ppublish
SO  - Support Care Cancer. 2012 Sep;20(9):1983-9. doi: 10.1007/s00520-011-1301-y. Epub 
      2011 Nov 22.


PMID- 22103939
OWN - NLM
STAT- MEDLINE
DCOM- 20120105
LR  - 20190518
IS  - 0261-1929 (Print)
IS  - 0261-1929 (Linking)
VI  - 39
IP  - 5
DP  - 2011 Oct
TI  - Veterinary science student preferences for the source of dog cadavers used in
      anatomy teaching.
PG  - 461-9
AB  - Live animals and cadavers are integral to veterinary education. In the year of
      this survey (2008), and in at least the five preceding years, cadavers obtained
      by euthanasia of healthy pound dogs and ex-racing greyhounds were dissected by
      students, during their veterinary anatomy classes at the University of Queensland
      School of Veterinary Science. Students may have ethical concerns about this. An
      alternative approach was to use donated dog cadavers. These are owned pet dogs
      that have died of natural causes or have been euthanised for medical reasons, and
      have been donated by their owners for the purposes of veterinary education.
      Veterinary students at the School were surveyed in 2008, in order to determine
      their preferences for cadaver source. Data from 406 questionnaires were analysed.
      Third-year and fifth-year veterinary students were more likely than first-year
      students to prefer pound-dog/greyhound cadavers over donated cadavers for anatomy
      dissection (p </= 0.002). Between 32% and 45% of the students had no preference
      for either source of cadaver. These findings are consistent with the hypothesis
      that veterinary students become more accepting of the euthanasia of unwanted
      healthy animals for education as they progress through the veterinary programme, 
      in contexts such as the current study. This could occur due to increased
      acceptance of the euthanasia of healthy animals generally, a decline in moral
      development, desensitisation, and/or the belief that healthy animal cadavers
      offer a superior learning experience.
CI  - 2011 FRAME.
FAU - Tiplady, Catherine
AU  - Tiplady C
AD  - School of Veterinary Science, University of Queensland, Queensland, Australia.
      catherine.tiplady@uqconnect.edu.au
FAU - Lloyd, Shan
AU  - Lloyd S
FAU - Morton, John
AU  - Morton J
LA  - eng
PT  - Journal Article
PL  - England
TA  - Altern Lab Anim
JT  - Alternatives to laboratory animals : ATLA
JID - 8110074
SB  - IM
MH  - Animals
MH  - *Cadaver
MH  - Data Collection
MH  - *Dissection
MH  - Dogs/*anatomy & histology
MH  - Education, Veterinary/*ethics
MH  - Humans
MH  - *Students
MH  - Surveys and Questionnaires
EDAT- 2011/11/23 06:00
MHDA- 2012/01/06 06:00
CRDT- 2011/11/23 06:00
PHST- 2011/11/23 06:00 [entrez]
PHST- 2011/11/23 06:00 [pubmed]
PHST- 2012/01/06 06:00 [medline]
AID - 10.1177/026119291103900507 [doi]
PST - ppublish
SO  - Altern Lab Anim. 2011 Oct;39(5):461-9. doi: 10.1177/026119291103900507.


PMID- 22103638
OWN - NLM
STAT- MEDLINE
DCOM- 20120221
LR  - 20151119
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 11
IP  - 3
DP  - 2011 Dec
TI  - On euthanasia: exploring psychological meaning and attitudes in a sample of
      Mexican physicians and medical students.
PG  - 146-53
LID - 10.1111/j.1471-8847.2011.00308.x [doi]
AB  - Euthanasia has become the subject of ethical and political debate in many
      countries including Mexico. Since many physicians are deeply concerned about
      euthanasia, due to their crucial participation in its decision and
      implementation, it is important to know the psychological meaning that the term
      'euthanasia' has for them, as well as their attitudes toward this practice. This 
      study explores psychological meaning and attitudes toward euthanasia in 546
      Mexican subjects, either medical students or physicians, who were divided into
      three groups: a) beginning students, b) advanced students, and c) physicians. We 
      used the semantic networks technique, which analyzed the words the participants
      associated with the term 'euthanasia'. Positive psychological meaning, as well as
      positive attitudes, prevailed among advanced students and physicians when
      defining euthanasia, whereas both positive and negative psychological meaning
      together with more ambivalent attitudes toward euthanasia predominated in
      beginning students. The findings are discussed in the context of a current debate
      on a bill proposing active euthanasia in Mexico City.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - del Rio, Asuncion Alvarez
AU  - del Rio AA
AD  - Departamento de Psiquiatria y Salud Mental, Facultad de Medicina, UNAM Instituto 
      de Investigaciones Psicologicas, Universidad Veracruzana, Mexico.
      asun57@gmail.com
FAU - Marvan, Ma Luisa
AU  - Marvan ML
LA  - eng
PT  - Journal Article
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - *Attitude to Death
MH  - Euthanasia/*psychology
MH  - Euthanasia, Active/psychology
MH  - Euthanasia, Passive/psychology
MH  - Female
MH  - Humans
MH  - Male
MH  - Mexico
MH  - Middle Aged
MH  - Physician's Role
MH  - Physicians/*psychology/statistics & numerical data
MH  - Students, Medical/*psychology/statistics & numerical data
MH  - Surveys and Questionnaires
EDAT- 2011/11/23 06:00
MHDA- 2012/02/22 06:00
CRDT- 2011/11/23 06:00
PHST- 2011/11/23 06:00 [entrez]
PHST- 2011/11/23 06:00 [pubmed]
PHST- 2012/02/22 06:00 [medline]
AID - 10.1111/j.1471-8847.2011.00308.x [doi]
PST - ppublish
SO  - Dev World Bioeth. 2011 Dec;11(3):146-53. doi: 10.1111/j.1471-8847.2011.00308.x.


PMID- 22103637
OWN - NLM
STAT- MEDLINE
DCOM- 20120221
LR  - 20140325
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 11
IP  - 3
DP  - 2011 Dec
TI  - Gender context of personalism in bioethics.
PG  - 136-45
LID - 10.1111/j.1471-8847.2011.00310.x [doi]
AB  - Personalism is one of the philosophical perspectives which hold that the reality 
      in person and the human person has the highest intrinsic value. This paper makes 
      reference to Louis Janssens' eight criteria in adequate consideration of the
      human person but further argues that there is need to consider people as situated
      agents especially within gender relational perspectives. The paper identifies
      gender as an important social construction that shapes the consideration of the
      human persons within socio-spatial spheres. The main crux of the paper is that
      there is a gender context of personalism and this has profound implications for
      bioethical agendas. Gender is part of the human condition, especially when we
      philosophically or sociologically engage the notion of equity and equality within
      the social system, because social realities in the relational perspective are not
      impartial, impersonal and equal. Gender does not determine morality but it plays 
      a role in morality and expectations from moral agents. Women have been
      categorised as a sociological group because their integrity, freedom/autonomy and
      dignity (which are basic concerns of bioethics) are capable of being threatened. 
      A gender perspective provides important incentives for moral theory which
      searches for possible conceptual imbalances or blind spots in ethical
      reflections. The paper refers to Sen's faces of gender inequality and expands on 
      the notion that natality inequality is one of the fundamental levels of gender
      inequality, which in turn is the primary starting agenda in bioethics. The paper 
      avers that the recognition of the fundamental importance of gender to the
      organization of social reality and the development of personal identities have
      important practical implications for bioethics.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Amzat, Jimoh
AU  - Amzat J
AD  - Department of Sociology, Usmanu Danfodiyo University, Sokoto, Nigeria.
      greatjoa@yahoo.co.uk
FAU - Grandi, Giovanni
AU  - Grandi G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
SB  - IM
MH  - Bioethics
MH  - Ethics, Medical
MH  - Female
MH  - Freedom
MH  - *Gender Identity
MH  - Humans
MH  - Male
MH  - *Personal Autonomy
MH  - *Personhood
MH  - Socioeconomic Factors
MH  - *Women
EDAT- 2011/11/23 06:00
MHDA- 2012/02/22 06:00
CRDT- 2011/11/23 06:00
PHST- 2011/11/23 06:00 [entrez]
PHST- 2011/11/23 06:00 [pubmed]
PHST- 2012/02/22 06:00 [medline]
AID - 10.1111/j.1471-8847.2011.00310.x [doi]
PST - ppublish
SO  - Dev World Bioeth. 2011 Dec;11(3):136-45. doi: 10.1111/j.1471-8847.2011.00310.x.


PMID- 22103634
OWN - NLM
STAT- MEDLINE
DCOM- 20120223
LR  - 20181201
IS  - 1365-294X (Electronic)
IS  - 0962-1083 (Linking)
VI  - 20
IP  - 23
DP  - 2011 Dec
TI  - Wild mice provide insights into natural killer cell maturation and memory.
PG  - 4827-9
LID - 10.1111/j.1365-294X.2011.05315.x [doi]
AB  - The immune system has evolved, and continues to evolve, in response to the
      selection pressure that infections exert on animals in their natural
      environments, yet much of our understanding about how the immune system functions
      comes from studies of model species maintained in the almost complete absence of 
      such environmental selection. The scientific discipline of immunology has among
      its aims the improvement of human and animal health by the application of
      immunological knowledge. As research on humans and domesticated animals is highly
      constrained-ethically, logistically and financially-experimental animal models
      have become an invaluable tool for dissecting the functioning of the immune
      system. The house mouse (Mus musculus) is by far the most widely used animal
      model in immunological research but laboratory-reared mice provide a very narrow 
      view of the immune system-that of a well-fed and comfortably housed animal with
      minimal exposure to microbial pathogens. Indeed, so much of our immunological
      knowledge comes from studies of a very few highly inbred mouse strains that-to
      all intents and purposes-our immunological knowledge is based on enormously
      detailed studies of very small numbers of individual mice. The limitations of
      studies in inbred strains of laboratory mice are well-recognized (Pedersen &
      Babayan 2011), but serious attempts to address these limitations have been few
      and far between. However, the emerging field of 'ecological immunology' where
      free-living populations are studied in their natural habitat is beginning to
      redress this imbalance (Viney et al. 2005; Martin et al. 2006; Owen et al. 2010; 
      Abolins et al. 2011). As demonstrated in the work by Boysen et al. (2011) in this
      issue of Molecular Ecology, studies in wild animal populations-especially
      free-living M. musculus-represent a valuable bridge between studies in humans and
      livestock and studies of captive animals.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Riley, Eleanor M
AU  - Riley EM
AD  - Department of Immunology and Infection, London School of Hygiene and Tropical
      Medicine, Keppel Street, London WC1E 7HT, UK. eleanor.riley@lshtm.ac.uk
FAU - Viney, Mark E
AU  - Viney ME
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - England
TA  - Mol Ecol
JT  - Molecular ecology
JID - 9214478
SB  - IM
CON - Mol Ecol. 2011 Dec;20(23):5103-10. PMID: 21895821
MH  - Animals
MH  - Female
MH  - Killer Cells, Natural/*physiology
MH  - *Lymphocyte Activation
MH  - Male
MH  - Mice/*immunology
EDAT- 2011/11/23 06:00
MHDA- 2012/02/24 06:00
CRDT- 2011/11/23 06:00
PHST- 2011/11/23 06:00 [entrez]
PHST- 2011/11/23 06:00 [pubmed]
PHST- 2012/02/24 06:00 [medline]
AID - 10.1111/j.1365-294X.2011.05315.x [doi]
PST - ppublish
SO  - Mol Ecol. 2011 Dec;20(23):4827-9. doi: 10.1111/j.1365-294X.2011.05315.x.


PMID- 22103464
OWN - NLM
STAT- MEDLINE
DCOM- 20120620
LR  - 20130520
IS  - 1651-2227 (Electronic)
IS  - 0803-5253 (Linking)
VI  - 101
IP  - 4
DP  - 2012 Apr
TI  - Decisions about life-sustaining measures in children: in whose best interests?
PG  - 333-6
LID - 10.1111/j.1651-2227.2011.02531.x [doi]
AB  - UNLABELLED: As the community of physicians and nurses dedicated to the care of
      critically ill children has gained ever more well-developed skill sets, the
      decision to either continue or forego life-sustaining measures has become less
      time-sensitive. As a result, there is greater opportunity for careful
      consideration and discussion. The core principle in making decisions about
      whether to continue or forego life-sustaining measures is the best interests of
      the child. However, there are many clinical situations wherein factors other than
      the child's best interests may influence treatment decisions. The present report 
      seeks to examine the notion that in the arena of paediatric critical care
      medicine, the decision-making process regarding life-sustaining measures may
      place insufficient priority upon the child's best interests. We examine actual,
      de-identified clinical situations, encountered in the critical care arena in two 
      categories: (i) cases that challenge the imperative to act in the child's best
      interests, and (ii) cases that compromise the ability of parents and caregivers
      to use child-centred, best-interests approaches to decision-making. Clarity
      surrounding the implications of a clinical decision for the patient is essential.
      Decisions that are not focused squarely on the child's best interests may
      compromise the delivery of optimally ethical end-of-life care. CONCLUSION: The
      cases and analysis may benefit parents and caregivers as they struggle with the
      difficult ethical issues that accompany decisions to continue or forego
      life-sustaining measures in children.
CI  - (c) 2011 The Author(s)/Acta Paediatrica (c) 2011 Foundation Acta Paediatrica.
FAU - Cornfield, David N
AU  - Cornfield DN
AD  - Center of Excellence in Pulmonary Biology, Division of Pediatric Pulmonary,
      Allergy and Critical Care Medicine, Department of Pediatrics, Stanford University
      Medical School, Stanford, CA, USA. cornfield@stanford.edu
FAU - Kahn, Jeffrey P
AU  - Kahn JP
LA  - eng
PT  - Journal Article
DEP - 20111213
PL  - Norway
TA  - Acta Paediatr
JT  - Acta paediatrica (Oslo, Norway : 1992)
JID - 9205968
SB  - IM
CIN - Acta Paediatr. 2012 Apr;101(4):337. PMID: 22489314
MH  - Child
MH  - Critical Illness
MH  - Decision Making/*ethics
MH  - *Dissent and Disputes
MH  - Humans
MH  - Life Support Care/ethics/*psychology
MH  - Patient-Centered Care/methods
MH  - Terminal Care/*ethics
MH  - Withholding Treatment/ethics
EDAT- 2011/11/23 06:00
MHDA- 2012/06/21 06:00
CRDT- 2011/11/23 06:00
PHST- 2011/11/23 06:00 [entrez]
PHST- 2011/11/23 06:00 [pubmed]
PHST- 2012/06/21 06:00 [medline]
AID - 10.1111/j.1651-2227.2011.02531.x [doi]
PST - ppublish
SO  - Acta Paediatr. 2012 Apr;101(4):333-6. doi: 10.1111/j.1651-2227.2011.02531.x. Epub
      2011 Dec 13.


PMID- 22102645
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20220409
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 1
IP  - 2
DP  - 2011
TI  - The At Home/Chez Soi trial protocol: a pragmatic, multi-site, randomised
      controlled trial of a Housing First intervention for homeless individuals with
      mental illness in five Canadian cities.
PG  - e000323
LID - 10.1136/bmjopen-2011-000323 [doi]
AB  - Introduction Housing First is a complex housing and support intervention for
      homeless individuals with mental health problems. It has a sufficient knowledge
      base and interest to warrant a test of wide-scale implementation in various
      settings. This protocol describes the quantitative design of a Canadian five
      city, $110 million demonstration project and provides the rationale for key
      scientific decisions. Methods A pragmatic, mixed methods, multi-site field trial 
      of the effectiveness of Housing First in Vancouver, Winnipeg, Toronto, Montreal
      and Moncton, is randomising approximately 2500 participants, stratified by high
      and moderate need levels, into intervention and treatment as usual groups.
      Quantitative outcome measures are being collected over a 2-year period and a
      qualitative process evaluation is being completed. Primary outcomes are housing
      stability, social functioning and, for the economic analyses, quality of life.
      Hierarchical linear modelling is the primary data analytic strategy. Ethics and
      dissemination Research ethics board approval has been obtained from 11
      institutions and a safety and adverse events committee is in place. The results
      of the multi-site analyses of outcomes at 12 months and 2 years will be reported 
      in a series of core scientific journal papers. Extensive knowledge exchange
      activities with non-academic audiences will occur throughout the duration of the 
      project. Trial registration number This study has been registered with the
      International Standard Randomised Control Trial Number Register and assigned
      ISRCTN42520374.
FAU - Goering, Paula N
AU  - Goering PN
AD  - Department of Psychiatry, Centre for Addiction and Mental Health, University of
      Toronto, Toronto, Ontario, Canada.
FAU - Streiner, David L
AU  - Streiner DL
FAU - Adair, Carol
AU  - Adair C
FAU - Aubry, Tim
AU  - Aubry T
FAU - Barker, Jayne
AU  - Barker J
FAU - Distasio, Jino
AU  - Distasio J
FAU - Hwang, Stephen W
AU  - Hwang SW
FAU - Komaroff, Janina
AU  - Komaroff J
FAU - Latimer, Eric
AU  - Latimer E
FAU - Somers, Julian
AU  - Somers J
FAU - Zabkiewicz, Denise M
AU  - Zabkiewicz DM
LA  - eng
PT  - Journal Article
DEP - 20111114
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3221290
EDAT- 2011/11/22 06:00
MHDA- 2011/11/22 06:01
CRDT- 2011/11/22 06:00
PHST- 2011/11/22 06:00 [entrez]
PHST- 2011/11/22 06:00 [pubmed]
PHST- 2011/11/22 06:01 [medline]
AID - bmjopen-2011-000323 [pii]
AID - 10.1136/bmjopen-2011-000323 [doi]
PST - epublish
SO  - BMJ Open. 2011 Nov 14;1(2):e000323. doi: 10.1136/bmjopen-2011-000323. Print 2011.


PMID- 22102583
OWN - NLM
STAT- MEDLINE
DCOM- 20120705
LR  - 20211021
IS  - 1362-4962 (Electronic)
IS  - 0305-1048 (Linking)
VI  - 40
IP  - Database issue
DP  - 2012 Jan
TI  - Mouse Phenome Database (MPD).
PG  - D887-94
LID - 10.1093/nar/gkr1061 [doi]
AB  - The Mouse Phenome Project was launched a decade ago to complement mouse genome
      sequencing efforts by promoting new phenotyping initiatives under standardized
      conditions and collecting the data in a central public database, the Mouse
      Phenome Database (MPD; http://phenome.jax.org). MPD houses a wealth of strain
      characteristics data to facilitate the use of the laboratory mouse in
      translational research for human health and disease, helping alleviate problems
      involving experimentation in humans that cannot be done practically or ethically.
      Data sets are voluntarily contributed by researchers from a variety of
      institutions and settings, or in some cases, retrieved by MPD staff from public
      sources. MPD maintains a growing collection of standardized reference data that
      assists investigators in selecting mouse strains for research applications;
      houses treatment/control data for drug studies and other interventions; offers a 
      standardized platform for discovering genotype-phenotype relationships; and
      provides tools for hypothesis testing. MPD improvements and updates since our
      last NAR report are presented, including the addition of new tools and features
      to facilitate navigation and data mining as well as the acquisition of new data
      (phenotypic, genotypic and gene expression).
FAU - Maddatu, Terry P
AU  - Maddatu TP
AD  - The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
FAU - Grubb, Stephen C
AU  - Grubb SC
FAU - Bult, Carol J
AU  - Bult CJ
FAU - Bogue, Molly A
AU  - Bogue MA
LA  - eng
GR  - P30 AG038070/AG/NIA NIH HHS/United States
GR  - HG003057/HG/NHGRI NIH HHS/United States
GR  - R01 DA028420/DA/NIDA NIH HHS/United States
GR  - DA028420/DA/NIDA NIH HHS/United States
GR  - P30 AG025707/AG/NIA NIH HHS/United States
GR  - MH071984/MH/NIMH NIH HHS/United States
GR  - AG038070/AG/NIA NIH HHS/United States
GR  - HL66611/HL/NHLBI NIH HHS/United States
GR  - AG025707/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20111118
PL  - England
TA  - Nucleic Acids Res
JT  - Nucleic acids research
JID - 0411011
SB  - IM
MH  - Animals
MH  - *Databases, Genetic
MH  - Female
MH  - Gene Expression
MH  - Genetic Association Studies
MH  - Genotype
MH  - Male
MH  - Mice/*genetics
MH  - *Phenotype
PMC - PMC3245053
EDAT- 2011/11/22 06:00
MHDA- 2012/07/06 06:00
CRDT- 2011/11/22 06:00
PHST- 2011/11/22 06:00 [entrez]
PHST- 2011/11/22 06:00 [pubmed]
PHST- 2012/07/06 06:00 [medline]
AID - gkr1061 [pii]
AID - 10.1093/nar/gkr1061 [doi]
PST - ppublish
SO  - Nucleic Acids Res. 2012 Jan;40(Database issue):D887-94. doi: 10.1093/nar/gkr1061.
      Epub 2011 Nov 18.


PMID- 22099922
OWN - NLM
STAT- MEDLINE
DCOM- 20120131
LR  - 20111121
IS  - 1521-6896 (Print)
IS  - 1521-6896 (Linking)
VI  - 25
IP  - 4
DP  - 2011 Dec
TI  - Best practice & research in anaesthesiology issue on new approaches in clinical
      research ethics in clinical research.
PG  - 569-82
LID - 10.1016/j.bpa.2011.08.003 [doi]
AB  - The history of ethics in clinical research parallels the history of abuse of
      human beings. The Nuremberg Code, Declaration of Helsinki, and the Belmont Report
      laid the foundations for modern research ethics. In the United States, the OHRP
      and the FDA provide guidelines for the ethical conduct of research. Investigators
      should be familiar with regulations concerning informed consent, doing research
      in vulnerable populations, and protection of privacy.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Schwenzer, Karen J
AU  - Schwenzer KJ
AD  - Department of Anesthesiology, University of Virginia Health System,
      Charlottesville, VA 22908-0710, USA. kjs2e@virginia.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Best Pract Res Clin Anaesthesiol
JT  - Best practice & research. Clinical anaesthesiology
JID - 101121446
SB  - IM
MH  - Anesthesiology/*ethics/standards
MH  - Biomedical Research/*ethics
MH  - Confidentiality/ethics
MH  - *Ethics, Research
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Informed Consent/ethics
MH  - *Practice Guidelines as Topic
MH  - Scientific Misconduct/ethics
MH  - United States
MH  - Vulnerable Populations
EDAT- 2011/11/22 06:00
MHDA- 2012/02/01 06:00
CRDT- 2011/11/22 06:00
PHST- 2011/07/01 00:00 [received]
PHST- 2011/08/12 00:00 [accepted]
PHST- 2011/11/22 06:00 [entrez]
PHST- 2011/11/22 06:00 [pubmed]
PHST- 2012/02/01 06:00 [medline]
AID - S1521-6896(11)00062-0 [pii]
AID - 10.1016/j.bpa.2011.08.003 [doi]
PST - ppublish
SO  - Best Pract Res Clin Anaesthesiol. 2011 Dec;25(4):569-82. doi:
      10.1016/j.bpa.2011.08.003.


PMID- 22099916
OWN - NLM
STAT- MEDLINE
DCOM- 20120131
LR  - 20220310
IS  - 1521-6896 (Print)
IS  - 1521-6896 (Linking)
VI  - 25
IP  - 4
DP  - 2011 Dec
TI  - In silico modelling of physiologic systems.
PG  - 499-510
LID - 10.1016/j.bpa.2011.08.006 [doi]
AB  - In silico modelling, in which computer models are developed to model a
      pharmacologic or physiologic process, is a logical extension of controlled in
      vitro experimentation. It is the natural result of the explosive increase in
      computing power available to the research scientist at continually decreasing
      cost. In silico modelling combines the advantages of both in vivo and in vitro
      experimentation, without subjecting itself to the ethical considerations and lack
      of control associated with in vivo experiments. Unlike in vitro experiments,
      which exist in isolation, in silico models allow the researcher to include a
      virtually unlimited array of parameters, which render the results more applicable
      to the organism as a whole. In silico modelling is best known for its extensive
      use in pharmacokinetic experimentation, the best-known example of which is the
      development of the three-compartment model. In addition, complex in silico models
      have been applied to pathophysiological problems to provide information which
      cannot be obtained practically or ethically by traditional clinical research
      methods. These experiments have led to the development of significant insights in
      subject matters ranging from pure physiology to congenital heart surgery,
      obstetric anaesthesia airway management, mechanical ventilation and
      cardiopulmonary bypass/ventricular support devices. The utility of these models
      is based on both the validity of the model framework as well as the corresponding
      assumptions. In vivo experimentation has validated some, but not all of the in
      silico strategies employed. We present a review illustrating by example how in
      silico modelling has been applied to a number of cardio-respiratory problems in
      states of health and disease, the purpose of which is to give the reader a sense 
      of the complexity and assumptions which underlie this diverse and
      underappreciated research strategy, as well as an introduction to a research
      strategy that will likely continue to grow in importance.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Colquitt, Richard B
AU  - Colquitt RB
AD  - Department of Anesthesiology, University of Virginia Health System,
      Charlottesville, VA 22908, USA.
FAU - Colquhoun, Douglas A
AU  - Colquhoun DA
FAU - Thiele, Robert H
AU  - Thiele RH
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Best Pract Res Clin Anaesthesiol
JT  - Best practice & research. Clinical anaesthesiology
JID - 101121446
SB  - IM
MH  - Anesthesia
MH  - Biomedical Research/*methods
MH  - Cardiovascular System/drug effects/physiopathology
MH  - Clinical Trials as Topic
MH  - *Computer Simulation
MH  - Humans
MH  - *Models, Biological
MH  - *Research Design
MH  - Respiratory System/drug effects/physiopathology
EDAT- 2011/11/22 06:00
MHDA- 2012/02/01 06:00
CRDT- 2011/11/22 06:00
PHST- 2011/06/17 00:00 [received]
PHST- 2011/08/11 00:00 [accepted]
PHST- 2011/11/22 06:00 [entrez]
PHST- 2011/11/22 06:00 [pubmed]
PHST- 2012/02/01 06:00 [medline]
AID - S1521-6896(11)00065-6 [pii]
AID - 10.1016/j.bpa.2011.08.006 [doi]
PST - ppublish
SO  - Best Pract Res Clin Anaesthesiol. 2011 Dec;25(4):499-510. doi:
      10.1016/j.bpa.2011.08.006.


PMID- 22099831
OWN - NLM
STAT- MEDLINE
DCOM- 20140930
LR  - 20111121
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 43
IP  - 9
DP  - 2011 Nov
TI  - Hand transplantation: is it an ethical decision, a bioethical one, or both?
PG  - 3512-5
LID - 10.1016/j.transproceed.2011.09.046 [doi]
AB  - Essays by Seigler and Emmanuel define some criteria and requirements when doing
      an innovative procedure such as hand transplantation to determine whether it is
      possible to conduct clinical research. These criteria and requirements take into 
      account the patient, the medical team, and society. However, we think that there 
      are still other considerations that have not been given sufficient emphasis to
      justify an innovative procedure and are mainly determined by the patient and his 
      environment, along with other quality-of-life issues, including social acceptance
      (according to cultural norms), appearance (body image), and function. There
      should be a balance between the patient, the medical team, and societal
      considerations in the decision process. Progressive societies are responsible for
      the distribution of the necessary resources to perform innovative procedures
      while controlling the costs of integral treatment and ensuring related
      investigations, thus facilitating the evaluation and advancement of innovative
      surgery. If these factors are taken into account along with the criteria already 
      outlined involving the patient's cultural dimensions and the involved costs a
      decision can be made whether to proceed with hand transplantation. Being a
      difficult complex decision, it is imperative that it be made not only by an
      individual or group, either the patient or the medical team (ethical decision),
      but in conjunction with public discussion (bioethical decision) that not only
      takes into account the risks, benefits, and costs, but by including all criteria 
      must also be at least technical, human, and social.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Bermudez, J
AU  - Bermudez J
AD  - Division of Hand and Microsurgery, Orthopedic and Trauma Surgery Department,
      Fundacion Santa Fe de Bogota University Hospital, Bogota, Colombia.
FAU - Latorre, L F
AU  - Latorre LF
FAU - Moreno, C
AU  - Moreno C
FAU - DeBedout, R
AU  - DeBedout R
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - *Bioethics
MH  - Biomedical Research/ethics
MH  - Decision Making
MH  - *Hand Transplantation
MH  - Humans
MH  - Program Development
MH  - Risk
MH  - Transplantation/*ethics/*methods/trends
EDAT- 2011/11/22 06:00
MHDA- 2014/10/01 06:00
CRDT- 2011/11/22 06:00
PHST- 2011/11/22 06:00 [entrez]
PHST- 2011/11/22 06:00 [pubmed]
PHST- 2014/10/01 06:00 [medline]
AID - S0041-1345(11)01325-X [pii]
AID - 10.1016/j.transproceed.2011.09.046 [doi]
PST - ppublish
SO  - Transplant Proc. 2011 Nov;43(9):3512-5. doi: 10.1016/j.transproceed.2011.09.046.


PMID- 22098925
OWN - NLM
STAT- MEDLINE
DCOM- 20120820
LR  - 20120427
IS  - 1873-491X (Electronic)
IS  - 0020-7489 (Linking)
VI  - 49
IP  - 5
DP  - 2012 May
TI  - Reflections on the ethics of internet newsgroup research.
PG  - 625-30
LID - 10.1016/j.ijnurstu.2011.10.018 [doi]
FAU - Bradley, Stephen K
AU  - Bradley SK
AD  - National University of Ireland Galway, Galway, Co. Galway, Ireland.
      stephen.bradley@nuigalway.ie
FAU - Carter, Bernie
AU  - Carter B
LA  - eng
PT  - Journal Article
DEP - 20111117
PL  - England
TA  - Int J Nurs Stud
JT  - International journal of nursing studies
JID - 0400675
SB  - IM
MH  - *Ethics, Research
MH  - *Internet
MH  - *Publishing
EDAT- 2011/11/22 06:00
MHDA- 2012/08/21 06:00
CRDT- 2011/11/22 06:00
PHST- 2010/08/03 00:00 [received]
PHST- 2011/10/05 00:00 [revised]
PHST- 2011/10/19 00:00 [accepted]
PHST- 2011/11/22 06:00 [entrez]
PHST- 2011/11/22 06:00 [pubmed]
PHST- 2012/08/21 06:00 [medline]
AID - S0020-7489(11)00415-9 [pii]
AID - 10.1016/j.ijnurstu.2011.10.018 [doi]
PST - ppublish
SO  - Int J Nurs Stud. 2012 May;49(5):625-30. doi: 10.1016/j.ijnurstu.2011.10.018. Epub
      2011 Nov 17.


PMID- 22098662
OWN - NLM
STAT- MEDLINE
DCOM- 20120325
LR  - 20111121
IS  - 1548-5609 (Electronic)
IS  - 1548-5595 (Linking)
VI  - 18
IP  - 6
DP  - 2011 Nov
TI  - Transplantation and the primary care physician.
PG  - 433-8
LID - 10.1053/j.ackd.2011.10.004 [doi]
AB  - Increasing appreciation of the survival benefits of kidney transplantation,
      compared with chronic dialysis, has resulted in more patients with kidney disease
      being referred and receiving organs. The evolving disparity between a rapidly
      increasing pool of candidates and a smaller pool of available donors has created 
      new issues for the physicians who care for kidney patients and their potential
      living donors. This article outlines current efforts to address the growing
      number of patients who await transplantation, including relaxation of traditional
      donation criteria, maximization of living donation, and donation schemas that
      permit incompatible donor-recipient pairs to participate through paired donation 
      and transplantation chains. New ethical issues faced by donors and recipients are
      discussed. Surgical advances that reduce the morbidity of donors are also
      described, as is the role of the primary physician in medical issues of both
      donors and recipients.
CI  - Copyright (c) 2011 National Kidney Foundation, Inc. Published by Elsevier Inc.
      All rights reserved.
FAU - McGill, Rita L
AU  - McGill RL
AD  - Division of Nephrology and Hypertension, West Penn Allegheny Health System,
      Allegheny General Hospital, Pittsburgh, PA 15212-4772, USA. rmcgill@wpahs.org
FAU - Ko, Tina Y
AU  - Ko TY
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Adv Chronic Kidney Dis
JT  - Advances in chronic kidney disease
JID - 101209214
SB  - IM
MH  - Cadaver
MH  - Humans
MH  - *Kidney Transplantation
MH  - Medical Tourism/ethics
MH  - *Physicians, Primary Care
MH  - Postoperative Care
MH  - Renal Insufficiency, Chronic/*surgery
MH  - Tissue Donors/supply & distribution
MH  - Tissue and Organ Procurement
MH  - Treatment Outcome
EDAT- 2011/11/22 06:00
MHDA- 2012/03/27 06:00
CRDT- 2011/11/22 06:00
PHST- 2011/06/01 00:00 [received]
PHST- 2011/10/14 00:00 [revised]
PHST- 2011/10/18 00:00 [accepted]
PHST- 2011/11/22 06:00 [entrez]
PHST- 2011/11/22 06:00 [pubmed]
PHST- 2012/03/27 06:00 [medline]
AID - S1548-5595(11)00144-3 [pii]
AID - 10.1053/j.ackd.2011.10.004 [doi]
PST - ppublish
SO  - Adv Chronic Kidney Dis. 2011 Nov;18(6):433-8. doi: 10.1053/j.ackd.2011.10.004.


PMID- 22098393
OWN - NLM
STAT- MEDLINE
DCOM- 20120822
LR  - 20161125
IS  - 1360-046X (Electronic)
IS  - 0268-8697 (Linking)
VI  - 26
IP  - 3
DP  - 2012 Jun
TI  - Comparison of CT perfusion parameters and microvessel density in intracranial
      hemangiopericytomas with peritumoral edema.
PG  - 340-6
LID - 10.3109/02688697.2011.629697 [doi]
AB  - PURPOSE: Intracranial hemangiopericytomas (HPCs) are rare, and they have a
      tendency for local recurrence and metastases. The purpose of this study was to
      evaluate the relationship between CT perfusion (CTP) parameters and microvessel
      density (MVD) of HPCs and compare CTP parameters in parenchyma and peritumoral
      edema of HPCs. MATERIALS AND METHODS: The study was approved by the ethics
      committee, and written informed consent was obtained. Ten patients with HPCs and 
      peritumoral edema, confirmed by pathological results, received 64-slice CT
      perfusion imaging before operation. To evaluate vascular attenuation of tumoral
      parenchyma, we immunostained the specimen sections for CD-34, measured the
      integrated optical density of all the positive stained CD-34 cells in the
      microscopic field, and calculated its ratio to total area of field as MVD.
      Perfusion analysis was calculated using the Patlak method. Using a 1-cm distance 
      from the outer enhancing tumor margin as a boundary, the peritumoral edema was
      divided into an immediate and a distant part. The quantitative CTP parameters,
      including cerebral blood volume (CBV), permeability-surface area product (PS) of 
      parenchyma, and immediate and distant peritumoral edemas, were compared. CBV and 
      PS in parenchyma and immediate and distant peritumoral edemas of HPCs were also
      compared to their respective contralateral normal white matter. The correlations 
      between MVD, CBV, and PS of tumoral parenchyma were analyzed. RESULTS: Positive
      correlations existed between CBV and MVD, PS and MVD (P < 0.05) respectively in
      the 10 patients. Furthermore, the values of CBV and PS in parenchyma of HPCs were
      significantly higher than those of the contralateral normal white matter and
      peritumoral edema (P < 0.05). The value of CBV in peritumoral edema of HPCs were 
      lower than that of contralateral normal white matter (P < 0.05), while the value 
      of PS in immediate and distant peritumoral edemas of HPCs were not significantly 
      difference with that of contralateral normal white matter (P > 0.05). Finally,
      the values of CBV and PS did not show a significant difference between immediate 
      and distant peritumoral edemas. CONCLUSIONS: CT perfusion imaging, especially
      determination of maximal CBV and corresponding PS values in the parenchyma, may
      be a useful and non-invasive technique for the preoperative evaluation of
      hemodynamic features of HPCs with peritumoral edema. CBV of peritumoral edema
      indicate that HPCs have a possibility of infiltration, this need further
      radiological-pathological research.
FAU - Shuang, Chen
AU  - Shuang C
AD  - Department of Radiology,Huashan hospital, Fudan University, Wulumuqizhong Road,
      Shanghai, China. shuang6895@yahoo.com.cn
FAU - Guang, Ren
AU  - Guang R
FAU - Xiaoyuan, Feng
AU  - Xiaoyuan F
FAU - Daoying, Geng
AU  - Daoying G
FAU - Yin, Wang
AU  - Yin W
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20111118
PL  - England
TA  - Br J Neurosurg
JT  - British journal of neurosurgery
JID - 8800054
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brain Edema/*diagnostic imaging
MH  - Brain Neoplasms/*blood supply
MH  - Female
MH  - Hemangiopericytoma/*blood supply/diagnostic imaging
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Microvessels/*diagnostic imaging
MH  - Middle Aged
MH  - *Rare Diseases/diagnostic imaging
MH  - Tomography, X-Ray Computed/methods
EDAT- 2011/11/22 06:00
MHDA- 2012/08/23 06:00
CRDT- 2011/11/22 06:00
PHST- 2011/11/22 06:00 [entrez]
PHST- 2011/11/22 06:00 [pubmed]
PHST- 2012/08/23 06:00 [medline]
AID - 10.3109/02688697.2011.629697 [doi]
PST - ppublish
SO  - Br J Neurosurg. 2012 Jun;26(3):340-6. doi: 10.3109/02688697.2011.629697. Epub
      2011 Nov 18.


PMID- 22097752
OWN - NLM
STAT- MEDLINE
DCOM- 20130103
LR  - 20111121
IS  - 1671-7104 (Print)
IS  - 1671-7104 (Linking)
VI  - 35
IP  - 4
DP  - 2011 Jul
TI  - [Ethic review on clinical experiments of medical devices in medical
      institutions].
PG  - 274-6
AB  - Clinical experiments are always used to evaluate the safety and validity of
      medical devices. The experiments have two types of clinical trying and testing.
      Ethic review must be done by the ethics committee of the medical department with 
      the qualification of clinical research, and the approval must be made before the 
      experiments. In order to ensure the safety and validity of clinical experiments
      of medical devices in medical institutions, the contents, process and approval
      criterions of the ethic review were analyzed and discussed.
FAU - Shuai, Wanjun
AU  - Shuai W
AD  - Department of Medical Engineering, First Affiliated Hospital to General Hospital 
      of PLA, Beijing 100048, China. smallshuai2002@hotmail.com
FAU - Chao, Yong
AU  - Chao Y
FAU - Wang, Ning
AU  - Wang N
FAU - Xu, Shining
AU  - Xu S
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Yi Liao Qi Xie Za Zhi
JT  - Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation
JID - 9426153
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Equipment and Supplies/*ethics
MH  - *Ethical Review
MH  - Humans
EDAT- 2011/11/22 06:00
MHDA- 2013/01/04 06:00
CRDT- 2011/11/22 06:00
PHST- 2011/11/22 06:00 [entrez]
PHST- 2011/11/22 06:00 [pubmed]
PHST- 2013/01/04 06:00 [medline]
PST - ppublish
SO  - Zhongguo Yi Liao Qi Xie Za Zhi. 2011 Jul;35(4):274-6.


PMID- 22097685
OWN - NLM
STAT- MEDLINE
DCOM- 20111213
LR  - 20111121
IS  - 0043-3144 (Print)
IS  - 0043-3144 (Linking)
VI  - 60
IP  - 4
DP  - 2011 Jul
TI  - Ethical issues in healthcare financing.
PG  - 498-501
AB  - The four goals of good healthcare are to relieve symptoms, cure disease, prolong 
      life and improve quality of life. Access to healthcare has been a perpetual
      challenge to healthcare providers who must take into account important factors
      such as equity, efficiency and effectiveness in designing healthcare systems to
      meet the four goals of good healthcare. The underlying philosophy may designate
      health as being a basic human right, an investment, a commodity to be bought and 
      sold, a political demand or an expenditure. The design, policies and operational 
      arrangements will usually reflect which of the above philosophies underpin the
      healthcare system, and consequently, access. Mechanisms for funding include
      fee-for-service, cost sharing (insurance, either private or government sponsored)
      free-of-fee at point of delivery (payments being made through general taxes,
      health levies, etc) or cost-recovery. For each of these methods of financial
      access to healthcare services, there are ethical issues which can compromise the 
      four principles of ethical practices in healthcare, viz beneficence,
      non-maleficence, autonomy and justice. In times of economic recession, providing 
      adequate healthcare will require governments, with support from external
      agencies, to focus on poverty reduction strategies through provision of
      preventive services such as immunization and nutrition, delivered at primary care
      facilities. To maximize the effect of such policies, it will be necessary to
      integrate policies to fashion an intersectoral approach.
FAU - Maharaj, S R
AU  - Maharaj SR
AD  - Department of Community Health and Psychiatry, The University of the West Indies,
      Kingston 7, Jamaica, West Indies. satnarine.maharaj@uwimona.edu.jm
FAU - Paul, T J
AU  - Paul TJ
LA  - eng
PT  - Journal Article
PL  - Jamaica
TA  - West Indian Med J
JT  - The West Indian medical journal
JID - 0417410
SB  - IM
MH  - *Bioethical Issues
MH  - Cost Sharing
MH  - Economic Recession
MH  - Financing, Organized
MH  - Health Services Accessibility/*economics/*ethics
MH  - Human Rights
MH  - Humans
EDAT- 2011/11/22 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/11/22 06:00
PHST- 2011/11/22 06:00 [entrez]
PHST- 2011/11/22 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 1580 [pii]
PST - ppublish
SO  - West Indian Med J. 2011 Jul;60(4):498-501.


PMID- 22097205
OWN - NLM
STAT- MEDLINE
DCOM- 20130801
LR  - 20161018
IS  - 1003-5370 (Print)
IS  - 1003-5370 (Linking)
VI  - 31
IP  - 10
DP  - 2011 Oct
TI  - [A multi-center, randomized control trial on clinical research education to
      diabetes patients].
PG  - 1359-63
AB  - OBJECTIVE: To assess the effect of implementing education about clinical research
      in changing the awareness and attitudes of diabetic patients. METHODS: A
      randomized control trial was implemented in 258 patients with diabetes from 6
      hospitals. The participants were assigned to the intervention group (129 cases,
      who received education about the clinical research) and the control group (129
      cases, who received no intervention). The outcome indicators were the variables
      on knowledge, attitude for the clinical research between before and after
      intervention in the same group and between the two groups. RESULTS: There was no 
      withdrawal or lost in the two groups. Comparing the contents between inter-groups
      and intra-group for 19 assignment questions, it showed statistical significance
      (P<0.05). After the patients received education, their knowledge about and
      attitude towards clinical research, informed consent, placebo, follow-up, random 
      allocation, and ethics, etc. were markedly improved. Their attitudes for the
      participants to join in scientific research, opinion, confidence were obviously
      changed, and it also showed that the method was feasible. The patients' education
      level was positively correlated with the clinical research educated outputs.
      CONCLUSION: This study proved the necessity for patients participating in future 
      clinical trials to receive education, as well as its feasibility and
      effectiveness.
FAU - Li, Zan-hua
AU  - Li ZH
AD  - Mobile Post-doctoral Stations at School of Economics, Shandong University & The
      Health Management Center in Second Hospital of Shandong University, Jinan.
FAU - Yang, Su-qin
AU  - Yang SQ
FAU - Liu, Jian-ping
AU  - Liu JP
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - China
TA  - Zhongguo Zhong Xi Yi Jie He Za Zhi
JT  - Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese
      journal of integrated traditional and Western medicine
JID - 9211576
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomedical Research/*education
MH  - Diabetes Mellitus/*prevention & control
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Patient Education as Topic
EDAT- 2011/11/22 06:00
MHDA- 2013/08/02 06:00
CRDT- 2011/11/22 06:00
PHST- 2011/11/22 06:00 [entrez]
PHST- 2011/11/22 06:00 [pubmed]
PHST- 2013/08/02 06:00 [medline]
PST - ppublish
SO  - Zhongguo Zhong Xi Yi Jie He Za Zhi. 2011 Oct;31(10):1359-63.


PMID- 22097103
OWN - NLM
STAT- MEDLINE
DCOM- 20111213
LR  - 20191210
IS  - 0022-2917 (Print)
IS  - 0022-2917 (Linking)
VI  - 48
IP  - 3
DP  - 2011 Fall
TI  - Descriptive analysis of YouTube music therapy videos.
PG  - 357-69
AB  - The purpose of this study was to conduct a descriptive analysis of music
      therapy-related videos on YouTube. Preliminary searches using the keywords music 
      therapy, music therapy session, and "music therapy session" resulted in listings 
      of 5000, 767, and 59 videos respectively. The narrowed down listing of 59 videos 
      was divided between two investigators and reviewed in order to determine their
      relationship to actual music therapy practice. A total of 32 videos were
      determined to be depictions of music therapy sessions. These videos were analyzed
      using a 16-item investigator-created rubric that examined both video specific
      information and therapy specific information. Results of the analysis indicated
      that audio and visual quality was adequate, while narrative descriptions and
      identification information were ineffective in the majority of the videos. The
      top 5 videos (based on the highest number of viewings in the sample) were
      selected for further analysis in order to investigate demonstration of the
      Professional Level of Practice Competencies set forth in the American Music
      Therapy Association (AMTA) Professional Competencies (AMTA, 2008). Four of the
      five videos met basic competency criteria, with the quality of the fifth video
      precluding evaluation of content. Of particular interest is the fact that none of
      the videos included credentialing information. Results of this study suggest the 
      need to consider ways to ensure accurate dissemination of music therapy-related
      information in the YouTube environment, ethical standards when posting music
      therapy session videos, and the possibility of creating AMTA standards for
      posting music therapy related video.
FAU - Gooding, Lori F
AU  - Gooding LF
AD  - University of Kentucky, USA.
FAU - Gregory, Dianne
AU  - Gregory D
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - England
TA  - J Music Ther
JT  - Journal of music therapy
JID - 0014162
SB  - IM
MH  - Humans
MH  - *Internet
MH  - *Music
MH  - Music Therapy/*methods
MH  - Personal Satisfaction
MH  - Stress, Psychological/prevention & control
MH  - Videodisc Recording/*standards
EDAT- 2011/11/22 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/11/22 06:00
PHST- 2011/11/22 06:00 [entrez]
PHST- 2011/11/22 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 10.1093/jmt/48.3.357 [doi]
PST - ppublish
SO  - J Music Ther. 2011 Fall;48(3):357-69. doi: 10.1093/jmt/48.3.357.


PMID- 22096809
OWN - NLM
STAT- MEDLINE
DCOM- 20120227
LR  - 20120328
IS  - 1868-8551 (Electronic)
IS  - 1868-596X (Linking)
VI  - 28
IP  - 3
DP  - 2011
TI  - SATIS ethics ranking of universities in Germany regarding animal use in
      education.
PG  - 243-4
FAU - Schmidt, Astrid
AU  - Schmidt A
FAU - Hohensee, Christiane
AU  - Hohensee C
FAU - Teichgraber, Ute
AU  - Teichgraber U
FAU - Schmidt, Andre
AU  - Schmidt A
LA  - eng
PT  - Letter
PL  - Germany
TA  - ALTEX
JT  - ALTEX
JID - 100953980
SB  - IM
MH  - Animal Experimentation/*ethics/*standards/statistics & numerical data
MH  - Animal Welfare
MH  - Animals
MH  - Curriculum
MH  - Education
MH  - Germany
MH  - Universities/*ethics/*standards/statistics & numerical data
EDAT- 2011/11/22 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/11/22 06:00
PHST- 2011/11/22 06:00 [entrez]
PHST- 2011/11/22 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
PST - ppublish
SO  - ALTEX. 2011;28(3):243-4.


PMID- 22096660
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 2190-8370 (Print)
IS  - 2151-2604 (Linking)
VI  - 219
IP  - 3
DP  - 2011
TI  - Are the American Psychological Association's Detainee Interrogation Policies
      Ethical and Effective?: Key Claims, Documents, and Results.
PG  - 150-158
AB  - After 9-11, the United States began interrogating detainees at settings such as
      Abu Ghraib, Bagram, and Guantanamo. The American Psychological Association (APA) 
      supported psychologists' involvement in interrogations, adopted formal policies, 
      and made an array of public assurances. This article's purpose is to highlight
      key APA decisions, policies, procedures, documents, and public statements in
      urgent need of rethinking and to suggest questions that may be useful in a
      serious assessment, such as, "However well intended, were APA's interrogation
      policies ethically sound?"; "Were they valid, realistic, and able to achieve
      their purpose?"; "Were other approaches available that would address
      interrogation issues more directly, comprehensively, and actively, that were more
      ethically and scientifically based, and that would have had a greater likelihood 
      of success?"; and "Should APA continue to endorse its post-9-11 detainee
      interrogation policies?"
FAU - Pope, Kenneth S
AU  - Pope KS
AD  - Norwalk, CT, USA.
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Z Psychol
JT  - Zeitschrift fur Psychologie
JID - 101313724
PMC - PMC3200196
EDAT- 2011/11/19 06:00
MHDA- 2011/11/19 06:01
CRDT- 2011/11/19 06:00
PHST- 2011/11/19 06:00 [entrez]
PHST- 2011/11/19 06:00 [pubmed]
PHST- 2011/11/19 06:01 [medline]
AID - 10.1027/2151-2604/a000062 [doi]
AID - zfp_219_3_150 [pii]
PST - ppublish
SO  - Z Psychol. 2011;219(3):150-158. doi: 10.1027/2151-2604/a000062.


PMID- 22096412
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111123
LR  - 20211021
IS  - 1179-1373 (Electronic)
IS  - 1179-1373 (Linking)
VI  - 3
DP  - 2011
TI  - Seroprevalence of Toxoplasma gondii IgG antibody in HIV-infected patients at the 
      Lagos University Teaching Hospital.
PG  - 101-5
LID - 10.2147/HIV.S15532 [doi]
AB  - BACKGROUND: Toxoplasmosis is caused by infection with a ubiquitous intracellular 
      protozoan parasite, Toxoplasma gondii. With the advent of the HIV pandemic in
      Nigeria, toxoplasmic encephalitis has become one of the more frequent
      opportunistic infections and the most commonly implicated cause of focal brain
      lesions complicating the course of AIDS. OBJECTIVES: This study was conducted to 
      compare the pattern of seroprevalence of T. gondii (Toxo-IgG) antibodies among
      HIV-infected persons presenting with neurological complications and those
      without. MATERIALS AND METHODS: Plasma specimens collected from 380 subjects were
      tested for Toxo- IgG antibodies by enzyme immunoassay technique and CD4
      estimation by flow cytometry. Close-ended questionnaires were applied to all
      respondents to collect relevant data, with ethical approval from the hospital
      ethical committee. Plasma was obtained from two study groups comprising 300
      HIV-positive respondents without neurological presentations, and 80 HIV-positive 
      respondents with neurological complications. RESULTS: Seroprevalence of Toxo-IgG 
      antibodies was 58% in the HIV-positive study group without neurological
      complications (of these, 79.2% were males and 38.5% were females) and 40% in the 
      study group with neurological complications (46.2% of these were males and 28.6% 
      were females). The overall seroprevalence of Toxo-IgG antibodies among the
      HIV-positive respondents (with and without neurological complications) was 54.2% 
      (206 of 380). Seroprevalence of Toxo-IgG antibodies was lowest among the educated
      subjects (19% of the respondents with tertiary education) and among females in
      both study groups. A higher proportion of the subjects with neurological
      complications had CD4 cell count <100 cells/muL compared with respondents without
      neurological defects (39% vs 22.7%; P = 0.000), but the seroprevalence of
      Toxo-IgG antibodies was higher in subjects without neurological complications
      (45% vs 31.3%; P = 0.000). CONCLUSION: Toxoplasmosis, though an important
      opportunistic infection in our environment, may not account for the majority of
      neurological complications observed in patients with HIV infection in our center.
FAU - Osunkalu, Vincent O
AU  - Osunkalu VO
AD  - Department of Haematology and Blood Transfusion, College of Medicine Idi-Araba,
      Lagos, Nigeria.
FAU - Akanmu, Sulaimon A
AU  - Akanmu SA
FAU - Ofomah, Nkolika J
AU  - Ofomah NJ
FAU - Onyiaorah, Igwebuike V
AU  - Onyiaorah IV
FAU - Adediran, Adewumi A
AU  - Adediran AA
FAU - Akinde, Ralph O
AU  - Akinde RO
FAU - Onwuezobe, Ifeanyi A
AU  - Onwuezobe IA
LA  - eng
PT  - Journal Article
DEP - 20110905
PL  - New Zealand
TA  - HIV AIDS (Auckl)
JT  - HIV/AIDS (Auckland, N.Z.)
JID - 101515943
PMC - PMC3218715
OTO - NOTNLM
OT  - Toxoplasma gondii antibody (Toxo-IgG)
OT  - neurological complication
OT  - seroprevalence
EDAT- 2011/11/19 06:00
MHDA- 2011/11/19 06:01
CRDT- 2011/11/19 06:00
PHST- 2011/11/19 06:00 [entrez]
PHST- 2011/11/19 06:00 [pubmed]
PHST- 2011/11/19 06:01 [medline]
AID - 10.2147/HIV.S15532 [doi]
AID - hiv-3-101 [pii]
PST - ppublish
SO  - HIV AIDS (Auckl). 2011;3:101-5. doi: 10.2147/HIV.S15532. Epub 2011 Sep 5.


PMID- 22095837
OWN - NLM
STAT- MEDLINE
DCOM- 20120720
LR  - 20120412
IS  - 1520-6394 (Electronic)
IS  - 1091-4269 (Linking)
VI  - 29
IP  - 2
DP  - 2012 Feb
TI  - Enrolling in deep brain stimulation research for depression: influences on
      potential subjects' decision making.
PG  - 139-46
LID - 10.1002/da.20916 [doi]
AB  - BACKGROUND: Ethical concerns regarding early-phase clinical trials of DBS for
      treatment-resistant depression (TRD) include the possibility that participants'
      decisions to enroll might be motivated by unrealistic expectations of personal
      benefit or minimization of risks. METHODS: Thematic analyses were conducted on a 
      sample of 26 adults considering participation in two DBS trials. Influences on
      the decision making of these potential DBS trial participants were derived from
      responses to questions posed in the MacArthur Competence Assessment Tool for
      Clinical Research (MacCAT-CR), a semi-structured interview designed to evaluate
      decisional capacity to consent to research. RESULTS: Participants cited numerous 
      factors as influential in their enrollment decisions, including perceived lack of
      other treatment options, desire to take initiative, beliefs about DBS as a novel 
      treatment, possibility of DBS efficacy, hoped-for improvements, potential risks
      and disadvantages of DBS or clinical trial participation, and altruism. No
      individual expressed a set of motivations or influencing factors that suggested
      compromised decision-making capacity or diminished voluntariness of decision
      making. CONCLUSIONS: These results suggest that individuals make the decision to 
      enroll in early-phase trials of DBS for TRD based on a number of complex and
      sometimes idiosyncratic considerations, and that the trials that were studied
      utilized sufficiently robust informed consent processes. These findings offer
      evidence that the emerging research area of DBS can be advanced in an ethically
      sound manner, provided that safeguards and processes for discussing trials with
      participants are carefully and proactively enacted.
CI  - (c) 2012 Wiley Periodicals, Inc.
FAU - Christopher, Paul P
AU  - Christopher PP
AD  - Department of Psychiatry, University of Massachusetts Medical School, Worcester, 
      Massachusetts, USA.
FAU - Leykin, Yan
AU  - Leykin Y
FAU - Appelbaum, Paul S
AU  - Appelbaum PS
FAU - Holtzheimer, Paul E 3rd
AU  - Holtzheimer PE 3rd
FAU - Mayberg, Helen S
AU  - Mayberg HS
FAU - Dunn, Laura B
AU  - Dunn LB
LA  - eng
SI  - ClinicalTrials.gov/NCT00367003
GR  - MH077869/MH/NIMH NIH HHS/United States
GR  - MH091501/MH/NIMH NIH HHS/United States
GR  - MH66062/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20111117
PL  - United States
TA  - Depress Anxiety
JT  - Depression and anxiety
JID - 9708816
SB  - IM
MH  - Adult
MH  - Clinical Trials as Topic
MH  - *Decision Making
MH  - *Deep Brain Stimulation
MH  - Depression/psychology/*therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Patient Participation
MH  - Treatment Failure
EDAT- 2011/11/19 06:00
MHDA- 2012/07/21 06:00
CRDT- 2011/11/19 06:00
PHST- 2011/09/28 00:00 [received]
PHST- 2011/10/22 00:00 [revised]
PHST- 2011/11/20 00:00 [accepted]
PHST- 2011/11/19 06:00 [entrez]
PHST- 2011/11/19 06:00 [pubmed]
PHST- 2012/07/21 06:00 [medline]
AID - 10.1002/da.20916 [doi]
PST - ppublish
SO  - Depress Anxiety. 2012 Feb;29(2):139-46. doi: 10.1002/da.20916. Epub 2011 Nov 17.


PMID- 22095357
OWN - NLM
STAT- MEDLINE
DCOM- 20120425
LR  - 20211021
IS  - 1541-0048 (Electronic)
IS  - 0090-0036 (Linking)
VI  - 102
IP  - 1
DP  - 2012 Jan
TI  - The future of public health ethics.
PG  - 9
LID - 10.2105/AJPH.2011.300365 [doi]
FAU - Rothstein, Mark A
AU  - Rothstein MA
LA  - eng
PT  - Editorial
DEP - 20111128
PL  - United States
TA  - Am J Public Health
JT  - American journal of public health
JID - 1254074
SB  - IM
MH  - Forecasting
MH  - Health Policy
MH  - Humans
MH  - Public Health/*ethics/legislation & jurisprudence/trends
PMC - PMC3490560
EDAT- 2011/11/19 06:00
MHDA- 2012/04/26 06:00
CRDT- 2011/11/19 06:00
PHST- 2011/11/19 06:00 [entrez]
PHST- 2011/11/19 06:00 [pubmed]
PHST- 2012/04/26 06:00 [medline]
AID - AJPH.2011.300365 [pii]
AID - 10.2105/AJPH.2011.300365 [doi]
PST - ppublish
SO  - Am J Public Health. 2012 Jan;102(1):9. doi: 10.2105/AJPH.2011.300365. Epub 2011
      Nov 28.


PMID- 22095352
OWN - NLM
STAT- MEDLINE
DCOM- 20120425
LR  - 20211203
IS  - 1541-0048 (Electronic)
IS  - 0090-0036 (Linking)
VI  - 102
IP  - 1
DP  - 2012 Jan
TI  - Beyond base pairs to bedside: a population perspective on how genomics can
      improve health.
PG  - 34-7
LID - 10.2105/AJPH.2011.300299 [doi]
AB  - A decade after the sequencing of the human genome, the National Human Genome
      Research Institute announced a strategic plan for genomic medicine. It calls for 
      evaluating the structure and biology of genomes, understanding the biology of
      disease, advancing the science of medicine, and improving the effectiveness of
      health care. Fulfilling the promise of genomics urgently requires a population
      perspective to complement the bench-to-bedside model of translation. A population
      approach should assess the contribution of genomics to health in the context of
      social and environmental determinants of disease; evaluate genomic applications
      that may improve health care; design strategies for integrating genomics into
      practice; address ethical, legal, and social issues; and measure the population
      health impact of new technologies.
FAU - Khoury, Muin J
AU  - Khoury MJ
AD  - Office of Public Health Genomics, Centers for Disease Control and Prevention,
      Atlanta, GA 30333, USA. muk1@cdc.gov
FAU - Gwinn, Marta
AU  - Gwinn M
FAU - Bowen, M Scott
AU  - Bowen MS
FAU - Dotson, W David
AU  - Dotson WD
LA  - eng
PT  - Journal Article
DEP - 20111128
PL  - United States
TA  - Am J Public Health
JT  - American journal of public health
JID - 1254074
SB  - IM
MH  - Delivery of Health Care
MH  - *Genomics/organization & administration
MH  - *Health Status
MH  - Humans
MH  - *Translational Research, Biomedical/organization & administration
PMC - PMC3490552
EDAT- 2011/11/19 06:00
MHDA- 2012/04/26 06:00
CRDT- 2011/11/19 06:00
PHST- 2011/11/19 06:00 [entrez]
PHST- 2011/11/19 06:00 [pubmed]
PHST- 2012/04/26 06:00 [medline]
AID - AJPH.2011.300299 [pii]
AID - 10.2105/AJPH.2011.300299 [doi]
PST - ppublish
SO  - Am J Public Health. 2012 Jan;102(1):34-7. doi: 10.2105/AJPH.2011.300299. Epub
      2011 Nov 28.


PMID- 22095345
OWN - NLM
STAT- MEDLINE
DCOM- 20120425
LR  - 20220311
IS  - 1541-0048 (Electronic)
IS  - 0090-0036 (Linking)
VI  - 102
IP  - 1
DP  - 2012 Jan
TI  - Against the very idea of the politicization of public health policy.
PG  - 44-9
LID - 10.2105/AJPH.2011.300325 [doi]
AB  - I criticize the concern over the politicization of public health policy as a
      justification for preferring a narrow to a broad model of public health. My
      critique proceeds along 2 lines. First, the fact that administrative structures
      and actors are primary sources of public health policy demonstrates its
      inescapably political and politicized nature. Second, historical evidence shows
      that public health in Great Britain and the United States has from its very
      inception been political and politicized. I conclude by noting legitimate ethical
      concerns regarding the political nature of public health policy and argue that
      open deliberation in a democratic social order is best served by acknowledging
      the constraints of the inescapably politicized process of public health
      policymaking.
FAU - Goldberg, Daniel S
AU  - Goldberg DS
AD  - Department of Bioethics and Interdisciplinary Studies, Brody School of Medicine, 
      East Carolina University, Greenville, NC 27834, USA. goldbergd@ecu.edu
LA  - eng
PT  - Historical Article
PT  - Journal Article
DEP - 20111128
PL  - United States
TA  - Am J Public Health
JT  - American journal of public health
JID - 1254074
SB  - IM
CIN - Am J Public Health. 2012 Jul;102(7):e1; author reply el-2. PMID: 22594726
MH  - *Health Policy/history
MH  - History, 19th Century
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Policy Making
MH  - *Politics
MH  - *Public Health/ethics/history
MH  - Public Health Administration
MH  - United States
PMC - PMC3490541
EDAT- 2011/11/19 06:00
MHDA- 2012/04/26 06:00
CRDT- 2011/11/19 06:00
PHST- 2011/11/19 06:00 [entrez]
PHST- 2011/11/19 06:00 [pubmed]
PHST- 2012/04/26 06:00 [medline]
AID - AJPH.2011.300325 [pii]
AID - 10.2105/AJPH.2011.300325 [doi]
PST - ppublish
SO  - Am J Public Health. 2012 Jan;102(1):44-9. doi: 10.2105/AJPH.2011.300325. Epub
      2011 Nov 28.


PMID- 22095338
OWN - NLM
STAT- MEDLINE
DCOM- 20120425
LR  - 20211021
IS  - 1541-0048 (Electronic)
IS  - 0090-0036 (Linking)
VI  - 102
IP  - 1
DP  - 2012 Jan
TI  - Ethical justification for conducting public health surveillance without patient
      consent.
PG  - 38-44
LID - 10.2105/AJPH.2011.300297 [doi]
AB  - Public health surveillance by necessity occurs without explicit patient consent. 
      There is strong legal and scientific support for maintaining name-based reporting
      of infectious diseases and other types of public health surveillance. We present 
      conditions under which surveillance without explicit patient consent is ethically
      justifiable using principles of contemporary clinical and public health ethics.
      Overriding individual autonomy must be justified in terms of the obligation of
      public health to improve population health, reduce inequities, attend to the
      health of vulnerable and systematically disadvantaged persons, and prevent harm. 
      In addition, data elements collected without consent must represent the minimal
      necessary interference, lead to effective public health action, and be maintained
      securely.
FAU - Lee, Lisa M
AU  - Lee LM
AD  - Office of Surveillance, Epidemiology, and Laboratory Services, Centers for
      Disease Control and Prevention, Atlanta, GA 30333, USA. LMLee@cdc.gov
FAU - Heilig, Charles M
AU  - Heilig CM
FAU - White, Angela
AU  - White A
LA  - eng
PT  - Journal Article
DEP - 20111128
PL  - United States
TA  - Am J Public Health
JT  - American journal of public health
JID - 1254074
SB  - IM
MH  - Bioethics
MH  - Humans
MH  - Informed Consent/*ethics
MH  - *Population Surveillance
MH  - Public Health/ethics
MH  - Risk
MH  - Social Responsibility
MH  - United States
PMC - PMC3490562
EDAT- 2011/11/19 06:00
MHDA- 2012/04/26 06:00
CRDT- 2011/11/19 06:00
PHST- 2011/11/19 06:00 [entrez]
PHST- 2011/11/19 06:00 [pubmed]
PHST- 2012/04/26 06:00 [medline]
AID - AJPH.2011.300297 [pii]
AID - 10.2105/AJPH.2011.300297 [doi]
PST - ppublish
SO  - Am J Public Health. 2012 Jan;102(1):38-44. doi: 10.2105/AJPH.2011.300297. Epub
      2011 Nov 28.


PMID- 22095330
OWN - NLM
STAT- MEDLINE
DCOM- 20120425
LR  - 20211021
IS  - 1541-0048 (Electronic)
IS  - 0090-0036 (Linking)
VI  - 102
IP  - 1
DP  - 2012 Jan
TI  - Global alcohol producers, science, and policy: the case of the International
      Center for Alcohol Policies.
PG  - 80-9
LID - 10.2105/AJPH.2011.300269 [doi]
AB  - In this article, I document strategies used by alcohol producers to influence
      national and global science and policy. Their strategies include producing
      scholarly publications with incomplete, distorted views of the science underlying
      alcohol policies; pressuring national and international governmental
      institutions; and encouraging collaboration of public health researchers with
      alcohol industry-funded organizations and researchers. I conclude with a call for
      an enhanced research agenda drawing on sources seldom used by public health
      research, more focused resourcing of global public health bodies such as the
      World Health Organization to counterbalance industry initiatives, development of 
      technical assistance and other materials to assist countries with effective
      alcohol-control strategies, and further development of an ethical stance
      regarding collaboration with industries that profit from unhealthy consumption of
      their products.
FAU - Jernigan, David H
AU  - Jernigan DH
AD  - Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of
      Public Health, Baltimore, MD 21218, USA. djernigan@jhsph.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111128
PL  - United States
TA  - Am J Public Health
JT  - American journal of public health
JID - 1254074
SB  - IM
CIN - Am J Public Health. 2012 Apr;102(4):583; author reply 583. PMID: 22397334
MH  - *Alcoholic Beverages
MH  - Beer
MH  - Biomedical Research/ethics
MH  - Cooperative Behavior
MH  - *Food Industry/economics/ethics/organization & administration
MH  - *Health Policy
MH  - Humans
MH  - Policy Making
MH  - Public Health
MH  - *Public Policy
MH  - Tobacco Industry
MH  - World Health Organization
PMC - PMC3490544
EDAT- 2011/11/19 06:00
MHDA- 2012/04/26 06:00
CRDT- 2011/11/19 06:00
PHST- 2011/11/19 06:00 [entrez]
PHST- 2011/11/19 06:00 [pubmed]
PHST- 2012/04/26 06:00 [medline]
AID - AJPH.2011.300269 [pii]
AID - 10.2105/AJPH.2011.300269 [doi]
PST - ppublish
SO  - Am J Public Health. 2012 Jan;102(1):80-9. doi: 10.2105/AJPH.2011.300269. Epub
      2011 Nov 28.


PMID- 22095059
OWN - NLM
STAT- MEDLINE
DCOM- 20140714
LR  - 20171107
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 4
DP  - 2013 Dec
TI  - A national collaboration process: Finnish engineering education for the benefit
      of people and environment.
PG  - 1557-69
LID - 10.1007/s11948-011-9330-y [doi]
AB  - The key stakeholders of the Finnish engineering education collaborated during
      2006-09 to reform the system of education, to face the challenges of the changing
      business environment and to create a national strategy for the Finnish
      engineering education. The work process was carried out using participatory work 
      methods. Impacts of sustainable development (SD) on engineering education were
      analysed in one of the subprojects. In addition to participatory workshops, the
      core part of the work on SD consisted of a research with more than 60 interviews 
      and an extensive literature survey. This paper discusses the results of the
      research and the work process of the Collaboration Group in the subproject of SD.
      It is suggested that enhancing systematic dialogue among key stakeholders using
      participatory work methods is crucial in increasing motivation and commitment in 
      incorporating SD in engineering education. Development of the context of learning
      is essential for improving skills of engineering graduates in some of the key
      abilities related to SD: systemic- and life-cycle thinking, ethical
      understanding, collaborative learning and critical reflection skills. This
      requires changing of the educational paradigm from teacher-centred to
      learner-centred applying problem- and project-oriented active learning methods.
FAU - Takala, A
AU  - Takala A
AD  - Laboratory of Environmental Engineering and Biotechnology, Tampere University of 
      Technology, P.O. Box 541, 33101, Tampere, Finland, annina.takala@tut.fi.
FAU - Korhonen-Yrjanheikki, K
AU  - Korhonen-Yrjanheikki K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111118
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
CIN - Sci Eng Ethics. 2013 Dec;19(4):1571-6. PMID: 24158522
MH  - Comprehension
MH  - *Conservation of Natural Resources
MH  - *Cooperative Behavior
MH  - Engineering/*education
MH  - Finland
MH  - Humans
MH  - Interviews as Topic
MH  - *Problem-Based Learning
MH  - Teaching/*methods
MH  - Thinking
EDAT- 2011/11/19 06:00
MHDA- 2014/07/16 06:00
CRDT- 2011/11/19 06:00
PHST- 2011/07/17 00:00 [received]
PHST- 2011/11/04 00:00 [accepted]
PHST- 2011/11/19 06:00 [entrez]
PHST- 2011/11/19 06:00 [pubmed]
PHST- 2014/07/16 06:00 [medline]
AID - 10.1007/s11948-011-9330-y [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Dec;19(4):1557-69. doi: 10.1007/s11948-011-9330-y. Epub 2011
      Nov 18.


PMID- 22094262
OWN - NLM
STAT- MEDLINE
DCOM- 20120605
LR  - 20220331
IS  - 1662-8063 (Electronic)
IS  - 1662-4246 (Linking)
VI  - 15
IP  - 2
DP  - 2012
TI  - Non-invasive prenatal genetic testing: a study of public attitudes.
PG  - 73-81
LID - 10.1159/000331254 [doi]
AB  - BACKGROUND/OBJECTIVES: Non-invasive prenatal genetic diagnostic (NIPD) tests are 
      being developed using cell-free fetal DNA in the maternal circulation. NIPD tests
      avoid or reduce the need for invasive diagnostic procedures for conditions like
      Down syndrome. Discussion of ethical and social implications of these techniques 
      is increasing. We report findings from a study of public attitudes relevant to
      the introduction of NIPD. A key aim was to examine the range of attitudes
      relevant to NIPD within a diverse sample. METHODS: Qualitative analysis of
      written free text 'first responses' to a written neutral description of NIPD as
      part of a Q-methodology study conducted with a purposive sample of the UK
      population (n = 71). RESULTS: The majority (63%) of respondents described their
      first response as positive. However, respondents displayed ambivalence,
      expressing positive views of individual/medical rationale for NIPD and unease
      concerning public health rationale and societal implications. Unease related to
      eugenic reasoning underlying existing prenatal testing, 'too much control' in
      reproduction, commercial provision, information and support requirements for
      expanded testing, and limiting the use of testing. CONCLUSIONS: These findings
      suggest that regulating and monitoring commercial provision of NIPD services, and
      monitoring introduction and clinical use, are a public preference.
CI  - Copyright (c) 2011 S. Karger AG, Basel.
FAU - Kelly, S E
AU  - Kelly SE
AD  - ESRC Centre for Genomics in Society, University of Exeter, Exeter, UK.
      s.e.kelly@exeter.ac.uk
FAU - Farrimond, H R
AU  - Farrimond HR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111115
PL  - Switzerland
TA  - Public Health Genomics
JT  - Public health genomics
JID - 101474167
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - DNA/*analysis
MH  - Female
MH  - Fetal Diseases/*diagnosis/genetics
MH  - Genetic Testing/*ethics/*methods
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pregnancy
MH  - Prenatal Diagnosis/*ethics/methods
MH  - Public Health
MH  - *Public Opinion
MH  - Young Adult
EDAT- 2011/11/19 06:00
MHDA- 2012/06/06 06:00
CRDT- 2011/11/19 06:00
PHST- 2010/10/06 00:00 [received]
PHST- 2011/07/11 00:00 [accepted]
PHST- 2011/11/19 06:00 [entrez]
PHST- 2011/11/19 06:00 [pubmed]
PHST- 2012/06/06 06:00 [medline]
AID - 000331254 [pii]
AID - 10.1159/000331254 [doi]
PST - ppublish
SO  - Public Health Genomics. 2012;15(2):73-81. doi: 10.1159/000331254. Epub 2011 Nov
      15.


PMID- 22094142
OWN - NLM
STAT- MEDLINE
DCOM- 20120319
LR  - 20111118
IS  - 1558-299X (Electronic)
IS  - 0095-4543 (Linking)
VI  - 38
IP  - 4
DP  - 2011 Dec
TI  - Vaccination refusal: ethics, individual rights, and the common good.
PG  - 717-28, ix
LID - 10.1016/j.pop.2011.07.009 [doi]
AB  - Among the obstacles to the success of vaccination programs is the apparent recent
      increase in hesitancy and outright resistance to the recommended vaccination
      schedule by some parents and patients. This article reviews the spectrum of
      patient or parental attitudes that may be described as vaccine refusal, explores 
      related ethical considerations in the context of the doctor-patient relationship 
      and public health, and evaluates the possible responses of physicians when
      encountering resistance to vaccination recommendations. Health care providers
      should view individuals hesitant about or opposed to vaccines not as frustrations
      or threats to public health, but as opportunities to educate and inform.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Schwartz, Jason L
AU  - Schwartz JL
AD  - Department of History and Sociology of Science, Center for Bioethics, University 
      of Pennsylvania, 3401 Market Street, Suite 320, Philadelphia, PA 19104, USA.
      jlschwa2@mail.med.upenn.edu
FAU - Caplan, Arthur L
AU  - Caplan AL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110917
PL  - United States
TA  - Prim Care
JT  - Primary care
JID - 0430463
RN  - 0 (Vaccines)
SB  - IM
MH  - Ethics, Medical
MH  - Human Rights
MH  - Humans
MH  - *Immunization Schedule
MH  - *Patient Compliance
MH  - Public Health
MH  - United States
MH  - Vaccines/*administration & dosage
EDAT- 2011/11/19 06:00
MHDA- 2012/03/20 06:00
CRDT- 2011/11/19 06:00
PHST- 2011/11/19 06:00 [entrez]
PHST- 2011/11/19 06:00 [pubmed]
PHST- 2012/03/20 06:00 [medline]
AID - S0095-4543(11)00058-3 [pii]
AID - 10.1016/j.pop.2011.07.009 [doi]
PST - ppublish
SO  - Prim Care. 2011 Dec;38(4):717-28, ix. doi: 10.1016/j.pop.2011.07.009. Epub 2011
      Sep 17.


PMID- 22094100
OWN - NLM
STAT- MEDLINE
DCOM- 20120413
LR  - 20151119
IS  - 1531-4332 (Electronic)
IS  - 1095-6433 (Linking)
VI  - 161
IP  - 2
DP  - 2012 Feb
TI  - Retention of different-sized particles and derived gut fill estimate in tammar
      wallabies (Macropus eugenii): physiological and methodological considerations.
PG  - 243-9
LID - 10.1016/j.cbpa.2011.11.003 [doi]
AB  - The capacity of the digestive tract is an important parameter in understanding
      digestive adaptations, particularly in herbivores. Measures of this capacity
      ('gut fill') are commonly performed in killed animals, which has ethical and
      logistical implications. Alternatively, dry matter gut contents (DMC) can be
      estimated in live animals from food intake, digesta retention and digestibility, 
      based on physical principles (Holleman and White, Can. J. Zool. 67, 488-494,
      1989). Although this method has been used to some extent, it still awaits
      thorough validation. Here we estimated DMC in seven tammar wallabies during 5-day
      feeding trials and compared the results to those gained from dissections
      immediately after the trials. Calculated DMC exceeded that actually measured by
      29 +/- 22%. A closer inspection of the data suggested that this was partly due to
      the fact that DMC as measured by dissection is susceptible to short-term
      influences such as daily variation in food intake, whereas the calculated DMC
      represents an integrative measure over the whole period of the feeding trial.
      Correlations between both the measured digesta retention times, and the
      calculated DMC, with the measured wet contents mass suggest that it is
      particularly the DMC determined via dissection that needs to be measured with
      care. For a comparison of gut capacities, the calculated DMC therefore can be
      considered adequate, but should for a more widespread use be validated in further
      studies including more species and experimental regimes controlling food intake
      variation. Additionally, we tested whether very small (100-500 mum) and small
      (500-1000 mum) particles were retained differently in the tammar wallabies. There
      was no indication of such a difference. Whether the macropod forestomach
      selectively passes a certain particle fraction (that represents microbes) with
      the generally faster-passing fluids remains to be investigated with even smaller 
      markers, e.g. labelled bacteria.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Munn, Adam J
AU  - Munn AJ
AD  - Institute for Conservation Biology and Environmental Management, School of
      Biological Sciences, The University of Wollongong, Wollonong, New South Wales,
      Australia. amunn@uow.edu.au
FAU - Tomlinson, Susie
AU  - Tomlinson S
FAU - Savage, Tom
AU  - Savage T
FAU - Clauss, Marcus
AU  - Clauss M
LA  - eng
PT  - Journal Article
DEP - 20111107
PL  - United States
TA  - Comp Biochem Physiol A Mol Integr Physiol
JT  - Comparative biochemistry and physiology. Part A, Molecular & integrative
      physiology
JID - 9806096
RN  - 0 (Biomarkers)
SB  - IM
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Biomass
MH  - Body Weight/physiology
MH  - Digestion/physiology
MH  - Female
MH  - Gastrointestinal Tract/*physiology
MH  - Macropodidae/*physiology
MH  - *Particle Size
MH  - Physiology/*methods
EDAT- 2011/11/19 06:00
MHDA- 2012/04/14 06:00
CRDT- 2011/11/19 06:00
PHST- 2011/09/28 00:00 [received]
PHST- 2011/10/31 00:00 [revised]
PHST- 2011/11/01 00:00 [accepted]
PHST- 2011/11/19 06:00 [entrez]
PHST- 2011/11/19 06:00 [pubmed]
PHST- 2012/04/14 06:00 [medline]
AID - S1095-6433(11)00304-7 [pii]
AID - 10.1016/j.cbpa.2011.11.003 [doi]
PST - ppublish
SO  - Comp Biochem Physiol A Mol Integr Physiol. 2012 Feb;161(2):243-9. doi:
      10.1016/j.cbpa.2011.11.003. Epub 2011 Nov 7.


PMID- 22093920
OWN - NLM
STAT- MEDLINE
DCOM- 20120127
LR  - 20220321
IS  - 1476-5616 (Electronic)
IS  - 0033-3506 (Linking)
VI  - 125
IP  - 11
DP  - 2011 Nov
TI  - Thinking outside the box: Aboriginal people's suggestions for conducting health
      studies with Aboriginal communities.
PG  - 747-53
LID - 10.1016/j.puhe.2011.08.006 [doi]
AB  - OBJECTIVES: Aboriginal people are under-represented in epidemiological research, 
      largely due to past failures to engage and recruit Aboriginal communities,
      research fatigue and the use of culturally inappropriate methods. A qualitative
      study was undertaken in rural and urban Aboriginal communities in north-eastern
      and south-western Ontario to identify culturally congruent public health research
      methodologies. STUDY DESIGN: A qualitative participatory research study using
      focus group discussions. METHODS: This study employed a participatory research
      framework to elicit methodological suggestions for conducting public health
      research with Aboriginal communities during focus groups with healthcare
      providers from six diverse Aboriginal health organizations in Ontario, Canada.
      RESULTS: Continuing requests for participation in health research studies have
      led to community exhaustion. Discussions explored appropriate methods to obtain
      community approval and support for a study, the need for cultural sensitivity
      training for researchers, the value of conducting studies of interest and benefit
      to the community, advantages and disadvantages of qualitative and quantitative
      studies, the benefit of both Aboriginal and non-Aboriginal ethics reviews, the
      importance of safeguarding trusted information, types of incentives that may
      enhance study participation, suggestions to improve the collection of
      questionnaire information and biological specimens, how to resolve contentious
      issues and dissemination of study results. CONCLUSION: In order to successfully
      engage Aboriginal people in health studies, researchers need to build rapport
      with communities, have a community presence, be respectful and collaborative,
      utilize incentives, and employ flexible and adaptive methodologies of reasonable 
      length. Oral interviews are preferred to self-completed information. The use of
      more mixed methods methodologies was suggested when quantitative data collection 
      is necessary. Communities expect presentations about research findings.
CI  - Copyright (c) 2011 The Royal Society of Public Health. Published by Elsevier Ltd.
      All rights reserved.
FAU - Maar, M A
AU  - Maar MA
AD  - Northern Ontario School of Medicine, Laurentian University, 935 Ramsey Lake Road,
      Sudbury, Ontario, Canada. mmaar@nosm.ca
FAU - Lightfoot, N E
AU  - Lightfoot NE
FAU - Sutherland, M E
AU  - Sutherland ME
FAU - Strasser, R P
AU  - Strasser RP
FAU - Wilson, K J
AU  - Wilson KJ
FAU - Lidstone-Jones, C M
AU  - Lidstone-Jones CM
FAU - Graham, D G
AU  - Graham DG
FAU - Beaudin, R
AU  - Beaudin R
FAU - Daybutch, G A
AU  - Daybutch GA
FAU - Dokis, B R
AU  - Dokis BR
FAU - Lesage, M T
AU  - Lesage MT
FAU - Raymond, M
AU  - Raymond M
FAU - Williamson, P
AU  - Williamson P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Public Health
JT  - Public health
JID - 0376507
SB  - IM
MH  - *Community-Based Participatory Research
MH  - Cultural Competency
MH  - Focus Groups
MH  - Humans
MH  - *Indians, North American
MH  - Ontario
MH  - Public Health/*trends
MH  - Rural Population
MH  - Urban Population
EDAT- 2011/11/19 06:00
MHDA- 2012/01/28 06:00
CRDT- 2011/11/19 06:00
PHST- 2010/07/20 00:00 [received]
PHST- 2011/06/30 00:00 [revised]
PHST- 2011/08/29 00:00 [accepted]
PHST- 2011/11/19 06:00 [entrez]
PHST- 2011/11/19 06:00 [pubmed]
PHST- 2012/01/28 06:00 [medline]
AID - S0033-3506(11)00253-8 [pii]
AID - 10.1016/j.puhe.2011.08.006 [doi]
PST - ppublish
SO  - Public Health. 2011 Nov;125(11):747-53. doi: 10.1016/j.puhe.2011.08.006.


PMID- 22093688
OWN - NLM
STAT- MEDLINE
DCOM- 20120404
LR  - 20111129
IS  - 1442-2018 (Electronic)
IS  - 1441-0745 (Linking)
VI  - 13
IP  - 4
DP  - 2011 Dec
TI  - Confusion and ethical issues surrounding the role of Japanese midwives in
      childbirth and abortion: a qualitative study.
PG  - 502-6
LID - 10.1111/j.1442-2018.2011.00647.x [doi]
AB  - This qualitative study describes midwives' experiences in providing care in both 
      pregnancy termination and childbirth in Japan. Midwives working in the general
      hospital maternity unit assist in both, which is an ethical issue warranting
      further exploration. Eleven midwives working in a general hospital were
      interviewed using a semistructured interview, and responses were coded using
      thematic analysis. Two major themes emerged: the experience of midwives involved 
      in childbirth and pregnancy termination (three subthemes: confusion about care of
      the baby and aborted fetus, inability to cater to different mothers' needs, and
      establishing emotional control) and professional awareness and attitude as a
      midwife (three subthemes: consistency with professional principles, suppression
      of feelings in relation to aborted fetus, and previous and current professional
      identities). We found that midwives are isolated in this important social moral
      issue and its accompanying professional confusion. Suppressing their feelings
      remains the most common way of dealing with the ambivalence of the roles they
      fulfill. Improved working conditions and enhanced training on aspects of
      professional ethics would assist in reducing professional confusion.
CI  - (c) 2011 Blackwell Publishing Asia Pty Ltd.
FAU - Mizuno, Maki
AU  - Mizuno M
AD  - Division of Health Science, Kanazawa University, 5-11-80 Kodatuno, Kanazawa city,
      Ishikawa, Japan. maki@mhs.mp.kanazawa-u.ac.jp
LA  - eng
PT  - Journal Article
DEP - 20111117
PL  - Australia
TA  - Nurs Health Sci
JT  - Nursing & health sciences
JID - 100891857
SB  - IM
MH  - Abortion, Induced/*ethics/psychology
MH  - Adaptation, Psychological
MH  - Adult
MH  - Confusion/*psychology
MH  - *Ethics, Professional
MH  - Female
MH  - Humans
MH  - Interview, Psychological
MH  - Japan
MH  - Middle Aged
MH  - Midwifery/*ethics
MH  - Parturition/*psychology
MH  - Pregnancy
MH  - *Professional Role
MH  - Qualitative Research
MH  - Social Identification
MH  - Stress, Psychological
MH  - Young Adult
EDAT- 2011/11/19 06:00
MHDA- 2012/04/05 06:00
CRDT- 2011/11/19 06:00
PHST- 2011/11/19 06:00 [entrez]
PHST- 2011/11/19 06:00 [pubmed]
PHST- 2012/04/05 06:00 [medline]
AID - 10.1111/j.1442-2018.2011.00647.x [doi]
PST - ppublish
SO  - Nurs Health Sci. 2011 Dec;13(4):502-6. doi: 10.1111/j.1442-2018.2011.00647.x.
      Epub 2011 Nov 17.


PMID- 22093391
OWN - NLM
STAT- MEDLINE
DCOM- 20120326
LR  - 20111118
IS  - 1744-1609 (Electronic)
IS  - 1744-1595 (Linking)
VI  - 9
IP  - 4
DP  - 2011 Dec
TI  - Skin tear prevention and management among patients in the acute aged care and
      rehabilitation units in the Australian Capital Territory: a best practice
      implementation project.
PG  - 429-34
LID - 10.1111/j.1744-1609.2011.00234.x [doi]
AB  - BACKGROUND: A skin tear is a traumatic wound that results from the separation of 
      the skin layers due to shearing forces, friction or blunt trauma that affects all
      people. Numerous preventative measures aim to reduce the skin tears and minimise 
      conditions that predispose the epidermis to injury. With the increasing elderly
      population in acute aged care, implementation of an evidence-based guideline is
      critical as changes to ageing skin integrity make this population more
      susceptible to skin tear. AIMS/OBJECTIVES: The aim of this project was to ensure 
      the practice of skin tear assessment, prevention and management among acute aged 
      care causes and rehabilitation patients was performed according to best available
      evidence. METHODS: This project utilised a pre- and post-implementation audit
      design using the Joanna Briggs Institute Practical Application of Clinical
      Evidence System and Getting Research into Practice programs. The project was
      conducted from June to November 2010 with the audits conducted in the acute aged 
      care and rehabilitation units of two public hospitals in the Australian Capital
      Territory involving a sample size of 96 patients at pre-audit and 95 patient at
      post-audit admitted during the audit period. A convenience sample of 20 nurses
      also consented to be observed. The audits were conducted after obtaining ethics
      approval and consent from patients and nurses. RESULTS: The results showed a
      significant change in compliance to the skin tear guidelines at
      post-implementation audit. Staff education in particular had a dramatic increase 
      from 20% to 98% and the point prevalence rate of hospital-acquired skin tear
      decreased from 10% to 0.15%. DISCUSSION/CONCLUSION: This project emphasised the
      importance of education of all personnel involved in patient care and that a
      simple assessment of skin integrity is critical in preventing and managing skin
      tear especially among the susceptible elderly population.
CI  - 2011 The Authors. International Journal of Evidence-Based Healthcare. 2011 The
      Joanna Briggs Institute.
FAU - Lopez, Violeta
AU  - Lopez V
AD  - Australian National University, RCNMP Medical School, Canberra Canberra Hospital,
      Surgical Department, Garran, Australia. violeta.lopez@act.gov.au
FAU - Dunk, Ann Marie
AU  - Dunk AM
FAU - Cubit, Katrina
AU  - Cubit K
FAU - Parke, Jill
AU  - Parke J
FAU - Larkin, David
AU  - Larkin D
FAU - Trudinger, Maria
AU  - Trudinger M
FAU - Stuart, Margaret
AU  - Stuart M
CN  - Joanna Briggs Institute
LA  - eng
PT  - Journal Article
PT  - Practice Guideline
PT  - Review
PL  - Australia
TA  - Int J Evid Based Healthc
JT  - International journal of evidence-based healthcare
JID - 101247063
SB  - IM
MH  - Acute Disease
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Australian Capital Territory/epidemiology
MH  - Benchmarking
MH  - Female
MH  - *Health Services for the Aged
MH  - Health Status Indicators
MH  - Humans
MH  - Male
MH  - Medical Audit
MH  - Prevalence
MH  - Program Development
MH  - *Program Evaluation
MH  - *Quality of Health Care
MH  - Rehabilitation Centers/*statistics & numerical data
MH  - Skin/*injuries
MH  - Skin Diseases/diagnosis/epidemiology/*prevention & control
MH  - Time Factors
MH  - Wound Healing
EDAT- 2011/11/19 06:00
MHDA- 2012/03/27 06:00
CRDT- 2011/11/19 06:00
PHST- 2011/11/19 06:00 [entrez]
PHST- 2011/11/19 06:00 [pubmed]
PHST- 2012/03/27 06:00 [medline]
AID - 10.1111/j.1744-1609.2011.00234.x [doi]
PST - ppublish
SO  - Int J Evid Based Healthc. 2011 Dec;9(4):429-34. doi:
      10.1111/j.1744-1609.2011.00234.x.


PMID- 22093245
OWN - NLM
STAT- MEDLINE
DCOM- 20121119
LR  - 20191210
IS  - 1365-3156 (Electronic)
IS  - 1360-2276 (Linking)
VI  - 17
IP  - 3
DP  - 2012 Mar
TI  - Critical review of the Stepwise Laboratory Improvement Process Towards
      Accreditation (SLIPTA): suggestions for harmonization, implementation and
      improvement.
PG  - 361-7
LID - 10.1111/j.1365-3156.2011.02917.x [doi]
AB  - OBJECTIVE: Clinical laboratories in low- and middle-income countries (LMIC) need 
      fundamental improvement because quality laboratory services are essential for the
      decision-making capacity of clinicians, health workers and public health
      authorities. To this end, a tiered accreditation scheme Stepwise Laboratory
      Improvement Process Towards Accreditation (SLIPTA) was developed by WHO-AFRO, CDC
      and others for clinical laboratories in LMIC. One to five stars are accredited to
      laboratories based on the level of compliance with a checklist. Our aim was to
      evaluate the quality and applicability of this accreditation scheme compared with
      international quality standards. METHODS: We performed a critical review of this 
      scheme to formulate recommendations for implementation, harmonization and
      improvement. Two analyses were performed: one assessing its coverage of the ISO
      15189:2007 standard and one to identify and evaluate priorities of the
      accreditation checklist. RESULTS: Although the content of the checklist covers
      all aspects of total quality management, it strongly prioritizes resource
      management activities. We recommend identifying critical requirements for each
      tier of accreditation to assure a certain level of quality for each tier or
      instead using a pass/fail approach towards accreditation. In addition, the
      checklist should include more questions for assessing proper management, ethics
      and continuous improvement to meet ISO 15189. CONCLUSION: Launching accreditation
      schemes for laboratories in LMIC should be encouraged. After further optimization
      of SLIPTA, clinical laboratories may certainly benefit, leading to more correctly
      diagnosed patients and less waste of resources.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Datema, Tjeerd A M
AU  - Datema TA
AD  - KIT Biomedical Research, Royal Tropical Institute, Amsterdam, The Netherlands.
FAU - Oskam, Linda
AU  - Oskam L
FAU - van Beers, Stella M
AU  - van Beers SM
FAU - Klatser, Paul R
AU  - Klatser PR
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
DEP - 20111118
PL  - England
TA  - Trop Med Int Health
JT  - Tropical medicine & international health : TM & IH
JID - 9610576
SB  - IM
MH  - Accreditation/*standards
MH  - Checklist/*standards
MH  - Decision Making
MH  - Developing Countries
MH  - Health Resources
MH  - Humans
MH  - International Cooperation
MH  - Laboratories/ethics/organization & administration/*standards
MH  - Public Health
MH  - Quality Control
MH  - *Quality Improvement
MH  - Total Quality Management
EDAT- 2011/11/19 06:00
MHDA- 2012/12/10 06:00
CRDT- 2011/11/19 06:00
PHST- 2011/11/19 06:00 [entrez]
PHST- 2011/11/19 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1111/j.1365-3156.2011.02917.x [doi]
PST - ppublish
SO  - Trop Med Int Health. 2012 Mar;17(3):361-7. doi: 10.1111/j.1365-3156.2011.02917.x.
      Epub 2011 Nov 18.


PMID- 22092905
OWN - NLM
STAT- MEDLINE
DCOM- 20120329
LR  - 20111118
IS  - 1553-2712 (Electronic)
IS  - 1069-6563 (Linking)
VI  - 18
IP  - 11
DP  - 2011 Nov
TI  - Ethics seminar: the hospice patient in the ED: an ethical approach to
      understanding barriers and improving care.
PG  - 1201-7
LID - 10.1111/j.1553-2712.2011.01200.x [doi]
AB  - Emergency physicians (EPs) are asked to evaluate and treat a growing population
      of hospice patients who present to the emergency department (ED) for a number of 
      important reasons. Hospice patients pose unique ethical challenges, and "best
      practices" for these patients can differ from the life-preserving interventions
      of usual ED care. Having a solid understanding of professional responsibilities
      and ethical principles is useful for guiding EP management of these patients. In 
      end-of-life care, EPs need to recognize that there are barriers and complexities 
      to the best management of hospice patients, but they need to commit to strategies
      that optimize their care. This article describes the case of a hospice patient
      who presented with sepsis and end-stage cancer to the ED. Patient, system, and
      physician factors made management decisions in the ED difficult. The goal in the 
      ED should be to determine the best way to address terminally ill patient needs
      while respecting wishes to limit interventions that will only increase suffering 
      near the end of life.
CI  - (c) 2011 by the Society for Academic Emergency Medicine.
FAU - Zieske, Michael
AU  - Zieske M
AD  - Department of Emergency Medicine, Denver Health Medical Center, CO, USA.
      mikezieske@msn.com
FAU - Abbott, Jean
AU  - Abbott J
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Acad Emerg Med
JT  - Academic emergency medicine : official journal of the Society for Academic
      Emergency Medicine
JID - 9418450
SB  - IM
MH  - Adult
MH  - Decision Making
MH  - Disease Management
MH  - Emergency Medical Services/*ethics
MH  - Emergency Medicine/*ethics/standards
MH  - Emergency Service, Hospital/*standards
MH  - *Ethics, Medical
MH  - Hospice Care/*ethics/*standards
MH  - Humans
MH  - Lung Neoplasms/therapy
MH  - Male
MH  - Physician-Patient Relations/ethics
MH  - Quality of Life
MH  - Resuscitation Orders
MH  - Shock, Septic/therapy
EDAT- 2011/11/19 06:00
MHDA- 2012/03/30 06:00
CRDT- 2011/11/19 06:00
PHST- 2011/11/19 06:00 [entrez]
PHST- 2011/11/19 06:00 [pubmed]
PHST- 2012/03/30 06:00 [medline]
AID - 10.1111/j.1553-2712.2011.01200.x [doi]
PST - ppublish
SO  - Acad Emerg Med. 2011 Nov;18(11):1201-7. doi: 10.1111/j.1553-2712.2011.01200.x.


PMID- 22092778
OWN - NLM
STAT- MEDLINE
DCOM- 20130919
LR  - 20220408
IS  - 1600-0838 (Electronic)
IS  - 0905-7188 (Linking)
VI  - 23
IP  - 2
DP  - 2013 Mar
TI  - Gateway to doping? Supplement use in the context of preferred competitive
      situations, doping attitude, beliefs, and norms.
PG  - 244-52
LID - 10.1111/j.1600-0838.2011.01374.x [doi]
AB  - Nutritional supplement (NS) use is widespread in sport. This study applied an
      integrated social cognitive approach to examine doping attitudes, beliefs, and
      self-reported doping use behavior across NS users (n = 96) and nonusers (n =
      116). Following ethical approval, 212 competitive athletes (age mean = 21.4, s = 
      4.5; 137 males) completed self-reported measures of doping-related social
      cognitions and behaviors, presented in an online format where completion implied 
      consent. Significantly more NS users (22.9%) reported doping compared with
      nonusers (6.0%; U = 4628.0, P < 0.05). NS users presented significantly more
      positive attitudes toward doping (U = 3152.0, P < 0.05) and expressed a
      significantly greater belief that doping is effective (U = 3152.0, P < 0.05).
      When presented with the scenario that performance-enhancing substances are
      effective and increase the possibility of winning, NS users were significantly
      more in favor of competing in situations that allow doping (U = 3504.5, P <
      0.05). In sum, doping use is three-and-a-half times more prevalent in NS users
      compared with nonusers. This finding is accompanied by significant differences in
      doping attitudes, norms, and beliefs. Thus, this article offers support for the
      gateway hypothesis; athletes who engage in legal performance enhancement
      practices appear to embody an "at-risk" group for transition toward doping.
      Education should be appropriately targeted.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Backhouse, S H
AU  - Backhouse SH
AD  - Carnegie Research Institute, Leeds Metropolitan University, Leeds, United
      Kingdom. s.backhouse@leedsmet.ac.uk
FAU - Whitaker, L
AU  - Whitaker L
FAU - Petroczi, A
AU  - Petroczi A
LA  - eng
PT  - Journal Article
DEP - 20110809
PL  - Denmark
TA  - Scand J Med Sci Sports
JT  - Scandinavian journal of medicine & science in sports
JID - 9111504
SB  - IM
MH  - Athletes/*psychology
MH  - *Attitude
MH  - *Dietary Supplements
MH  - Doping in Sports/*statistics & numerical data
MH  - Female
MH  - Humans
MH  - Male
MH  - Self Report
MH  - Sex Factors
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2011/11/19 06:00
MHDA- 2013/09/21 06:00
CRDT- 2011/11/19 06:00
PHST- 2011/06/20 00:00 [accepted]
PHST- 2011/11/19 06:00 [entrez]
PHST- 2011/11/19 06:00 [pubmed]
PHST- 2013/09/21 06:00 [medline]
AID - 10.1111/j.1600-0838.2011.01374.x [doi]
PST - ppublish
SO  - Scand J Med Sci Sports. 2013 Mar;23(2):244-52. doi:
      10.1111/j.1600-0838.2011.01374.x. Epub 2011 Aug 9.


PMID- 22092539
OWN - NLM
STAT- MEDLINE
DCOM- 20131107
LR  - 20130415
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 27
IP  - 4
DP  - 2013 May
TI  - Stem cell treatments in China: rethinking the patient role in the global
      bio-economy.
PG  - 194-207
LID - 10.1111/j.1467-8519.2011.01929.x [doi]
AB  - The paper looks in detail at patients that were treated at one of the most
      discussed companies operating in the field of untried stem cell treatments, Beike
      Biotech of Shenzhen, China. Our data show that patients who had been treated at
      Beike Biotech view themselves as proactively pursuing treatment choices that are 
      not available in their home countries. These patients typically come from a broad
      variety of countries: China, the United Kingdom, the United States, South Africa 
      and Australia. Among the patients we interviewed there seemed to be both an
      awareness of the general risks involved in such experimental treatments and a
      readiness to accept those risks weighed against the possible benefits. We
      interpret this evidence as possibly reflecting the emergence of risk-taking
      patients as 'consumers' of medical options as well as the drive of patients to
      seek treatment options in the global arena, rather than being hindered by the
      ethical and regulatory constraints of their home countries. Further, we found
      that these patients tend to operate in more or less stable networks and groups in
      which they interact and cooperate closely and develop opinions and assessments of
      available treatment options for their ailments. These patients also perform a
      multiple role as patients, research subjects, and research funders because they
      are required to pay their way into treatment and research activities. This new
      social dynamics of patienthood has important implications for the ethical
      governance of stem cell treatments.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Chen, Haidan
AU  - Chen H
AD  - Center for the Study of Language and Cognition, Zhejiang University, China
      University of Vienna and Kyung Hee University in Seoul, Korea.
FAU - Gottweis, Herbert
AU  - Gottweis H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111117
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - China
MH  - Human Experimentation/ethics
MH  - Humans
MH  - *Medical Tourism/economics/ethics
MH  - Patient Satisfaction
MH  - Research Design
MH  - *Stem Cell Transplantation/ethics/standards
MH  - *Stem Cells
EDAT- 2011/11/19 06:00
MHDA- 2013/11/08 06:00
CRDT- 2011/11/19 06:00
PHST- 2011/11/19 06:00 [entrez]
PHST- 2011/11/19 06:00 [pubmed]
PHST- 2013/11/08 06:00 [medline]
AID - 10.1111/j.1467-8519.2011.01929.x [doi]
PST - ppublish
SO  - Bioethics. 2013 May;27(4):194-207. doi: 10.1111/j.1467-8519.2011.01929.x. Epub
      2011 Nov 17.


PMID- 22092536
OWN - NLM
STAT- MEDLINE
DCOM- 20131210
LR  - 20130513
IS  - 1472-8206 (Electronic)
IS  - 0767-3981 (Linking)
VI  - 27
IP  - 3
DP  - 2013 Jun
TI  - Paracetamol and opioid pathways: a pilot randomized clinical trial.
PG  - 339-45
LID - 10.1111/j.1472-8206.2011.01010.x [doi]
AB  - Previous studies suggest that the antinociceptive action of paracetamol
      (acetaminophen, APAP) might involve descending inhibitory pain pathways and the
      opioidergic system: this study explores this issue in humans with naloxone, the
      opioid antagonist. After ethical approval, 12 healthy male volunteers were
      included in this randomized, controlled, double-blind, crossover, four-arm study.
      They were administered intravenous paracetamol (APAP 1 g) or saline (placebo, pl)
      followed at 100 min with IV naloxone (Nal 8 mg) or saline, every week for 4
      weeks. The amplitude of cerebral potentials evoked by thermal/painful stimuli
      applied on the arm was recorded nine times over 150 min, witnessing of pain
      integration at central level. Amplitude changes as well as areas under the curve 
      (AUCs) over 150 min were compared for the four treatments by repeated measures
      ANOVA (significance 0.05). Amplitude changes were significant for APAP/pl vs.
      pl/pl at t150: -44% (95%CI -58 to -30) vs. -27% (95%CI -37 to -17; P < 0.05) but 
      not vs. APAP/Nal. AUC (0-150) of APAP/pl is significantly different from pl/pl
      (-3452%.min (95%CI -4705 to -2199) vs. -933% min (95%CI -2273 to 407; P = 0.015) 
      but not from APAP/Nal (-1731% min (95%CI -3676 to 214; P = 0.08) and other
      treatments. AUC (90-150) is not significantly different. This pilot study shows
      for the first time in human volunteers that naloxone does not inhibit paracetamol
      antinociception, suggesting no significant implication of the opioid system in
      paracetamol mechanism of action: this needs be confirmed on a larger number of
      subjects.
CI  - (c) 2011 The Authors Fundamental and Clinical Pharmacology (c) 2011 Societe
      Francaise de Pharmacologie et de Therapeutique. Published by John Wiley & Sons
      Ltd.
FAU - Pickering, Gisele
AU  - Pickering G
AD  - CHU Clermont-Ferrand, Centre de Pharmacologie Clinique, F-63003 Clermont-Ferrand,
      France. gisele.pickering@u-clermont1.fr
FAU - Moustafa, Fares
AU  - Moustafa F
FAU - Desbrandes, Stephanie
AU  - Desbrandes S
FAU - Cardot, J Michel
AU  - Cardot JM
FAU - Roux, Delphine
AU  - Roux D
FAU - Dubray, Claude
AU  - Dubray C
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20111117
PL  - England
TA  - Fundam Clin Pharmacol
JT  - Fundamental & clinical pharmacology
JID - 8710411
RN  - 0 (Analgesics, Non-Narcotic)
RN  - 0 (Narcotic Antagonists)
RN  - 362O9ITL9D (Acetaminophen)
RN  - 36B82AMQ7N (Naloxone)
SB  - IM
MH  - Acetaminophen/*pharmacology
MH  - Adult
MH  - Analgesics, Non-Narcotic/*pharmacology
MH  - Analysis of Variance
MH  - Cross-Over Studies
MH  - Double-Blind Method
MH  - Evoked Potentials/drug effects
MH  - Humans
MH  - Injections, Intravenous
MH  - Male
MH  - Naloxone/*pharmacology
MH  - Narcotic Antagonists/*pharmacology
MH  - Pain/drug therapy
MH  - Pilot Projects
MH  - Prospective Studies
MH  - Young Adult
EDAT- 2011/11/19 06:00
MHDA- 2013/12/16 06:00
CRDT- 2011/11/19 06:00
PHST- 2011/11/19 06:00 [entrez]
PHST- 2011/11/19 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1111/j.1472-8206.2011.01010.x [doi]
PST - ppublish
SO  - Fundam Clin Pharmacol. 2013 Jun;27(3):339-45. doi:
      10.1111/j.1472-8206.2011.01010.x. Epub 2011 Nov 17.


PMID- 22092421
OWN - NLM
STAT- MEDLINE
DCOM- 20120325
LR  - 20111118
IS  - 1525-1446 (Electronic)
IS  - 0737-1209 (Linking)
VI  - 28
IP  - 5
DP  - 2011 Sep-Oct
TI  - The ethics of international studies.
PG  - 387-8
LID - 10.1111/j.1525-1446.2011.00980.x [doi]
FAU - Hays, Judith C
AU  - Hays JC
LA  - eng
PT  - Editorial
PL  - United States
TA  - Public Health Nurs
JT  - Public health nursing (Boston, Mass.)
JID - 8501498
SB  - IM
MH  - *Editorial Policies
MH  - Human Experimentation/*ethics/legislation & jurisprudence
MH  - Humans
MH  - Internationality
MH  - Nursing Research/*ethics
MH  - *Periodicals as Topic
MH  - *Public Health Nursing
MH  - United States
MH  - Vulnerable Populations
EDAT- 2011/11/19 06:00
MHDA- 2012/03/27 06:00
CRDT- 2011/11/19 06:00
PHST- 2011/11/19 06:00 [entrez]
PHST- 2011/11/19 06:00 [pubmed]
PHST- 2012/03/27 06:00 [medline]
AID - 10.1111/j.1525-1446.2011.00980.x [doi]
PST - ppublish
SO  - Public Health Nurs. 2011 Sep-Oct;28(5):387-8. doi:
      10.1111/j.1525-1446.2011.00980.x.


PMID- 22092192
OWN - NLM
STAT- MEDLINE
DCOM- 20120213
LR  - 20111222
IS  - 1532-5415 (Electronic)
IS  - 0002-8614 (Linking)
VI  - 59
IP  - 12
DP  - 2011 Dec
TI  - Resident physician interactions with surrogate decision-makers: the resident
      experience.
PG  - 2341-6
LID - 10.1111/j.1532-5415.2011.03728.x [doi]
AB  - This study explored interactions between medical residents and patient surrogates
      in order to clarify resident understanding of roles and relationships, resident
      emotional experience, and resident learning processes. Qualitative analysis of
      in-depth interviews were used involving three family medicine residency programs 
      serving culturally diverse, urban, underserved patient populations. Eighteen
      second- and third-year trainees described a memorable interaction with a
      surrogate and then were prompted to discuss their learning experience and their
      role in the interaction. Interviews were transcribed verbatim and analyzed
      through an iterative process. Residents experienced significant emotional burden 
      during interactions yet continued to value their relationships with surrogates.
      Despite their reservations about giving recommendations, residents adopted a
      variety of roles with surrogates as they gave support, information, and advice.
      Although residents reported little formal education about surrogate
      decision-making, they relied on passive role modeling and their own previous
      experiences to help surrogates make decisions. Residents have complex and
      emotionally significant interactions with surrogates despite minimal formal
      education about surrogate decision-making. Educational efforts should seek to
      help residents understand their own emotions and the ethical beliefs that
      underlie the roles they adopt with surrogates. This will help residents to
      facilitate value-based conversations with surrogates and better support
      surrogates in the decision-making process.
CI  - (c) 2011, Copyright the Authors Journal compilation (c) 2011, The American
      Geriatrics Society.
FAU - Reckrey, Jennifer M
AU  - Reckrey JM
AD  - Brookdale Department of Geriatrics and Palliative Medicine, Mount Sinai School of
      Medicine, New York, New York 10029, USA. Jennifer.reckrey@mssm.edu
FAU - McKee, M Diane
AU  - McKee MD
FAU - Sanders, Justin J
AU  - Sanders JJ
FAU - Lipman, Hannah I
AU  - Lipman HI
LA  - eng
PT  - Journal Article
DEP - 20111031
PL  - United States
TA  - J Am Geriatr Soc
JT  - Journal of the American Geriatrics Society
JID - 7503062
SB  - IM
MH  - *Decision Making
MH  - Humans
MH  - *Internship and Residency
MH  - *Professional-Family Relations
EDAT- 2011/11/19 06:00
MHDA- 2012/02/14 06:00
CRDT- 2011/11/19 06:00
PHST- 2011/11/19 06:00 [entrez]
PHST- 2011/11/19 06:00 [pubmed]
PHST- 2012/02/14 06:00 [medline]
AID - 10.1111/j.1532-5415.2011.03728.x [doi]
PST - ppublish
SO  - J Am Geriatr Soc. 2011 Dec;59(12):2341-6. doi: 10.1111/j.1532-5415.2011.03728.x. 
      Epub 2011 Oct 31.


PMID- 22092150
OWN - NLM
STAT- MEDLINE
DCOM- 20120112
LR  - 20220321
IS  - 1532-5415 (Electronic)
IS  - 0002-8614 (Linking)
VI  - 59
IP  - 11
DP  - 2011 Nov
TI  - Patient participation in medical and social decisions in Alzheimer's disease.
PG  - 2045-52
LID - 10.1111/j.1532-5415.2011.03661.x [doi]
AB  - OBJECTIVES: To analyze the preferences of people with amnestic mild cognitive
      impairment (aMCI) and mild dementia in Alzheimer's disease (AD) regarding
      different aspects of healthcare-related decisions, to correlate these findings
      with different measures of decision-making capacity, and to explore the views of 
      relatives and referring physicians. DESIGN: Cross-sectional survey. SETTING:
      University-based memory clinic in Munich, Germany. PARTICIPANTS: One hundred
      people with aMCI or mild AD, their relatives (N = 99), and their referring
      physicians (N = 93). MEASUREMENTS: Participation preferences and decisional
      capacity and assessment of these measures according to relatives and physicians. 
      RESULTS: Patients had a preference for participation in healthcare-related
      decisions, especially in social ones. Overall, individuals wanted their relatives
      to play a secondary role in decision-making. Relatives and referring physicians
      performed poorly in predicting the individuals' participation preferences, and
      relatives wanted to attribute less decision-making power to patients than the
      patients did themselves. Patients refrained from participation if they had lower 
      Mini-Mental State Examination scores or were unsure about their decisional
      capacity. There were deficits in decision-making capacity, which mostly related
      to understanding of the information presented. There was only weak correlation
      between the different measures (patient's, relative's, and physician's estimate, 
      MacArthur Competence Assessment Tool for Treatment) of the patients' decisional
      capacity. CONCLUSION: The combination of marked participation preferences and
      impairments in the decisional capacity of individuals with aMCI and early AD
      constitute an ethical and practical challenge. A thorough implementation of
      structured probes of the patients' decisional capacity combined with
      interventions that aid patients in their decision-making capability might help to
      overcome some of these challenges.
CI  - (c) 2011, Copyright the Authors Journal compilation (c) 2011, The American
      Geriatrics Society.
FAU - Hamann, Johannes
AU  - Hamann J
AD  - Department of Psychiatry, Technische Universitat Munchen, Munchen, Germany.
      j.hamann@lrz.tum.de
FAU - Bronner, Katharina
AU  - Bronner K
FAU - Margull, Julia
AU  - Margull J
FAU - Mendel, Rosmarie
AU  - Mendel R
FAU - Diehl-Schmid, Janine
AU  - Diehl-Schmid J
FAU - Buhner, Markus
AU  - Buhner M
FAU - Klein, Reinhold
AU  - Klein R
FAU - Schneider, Antonius
AU  - Schneider A
FAU - Kurz, Alexander
AU  - Kurz A
FAU - Perneczky, Robert
AU  - Perneczky R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111022
PL  - United States
TA  - J Am Geriatr Soc
JT  - Journal of the American Geriatrics Society
JID - 7503062
SB  - IM
MH  - *Advance Directive Adherence
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/diagnosis/*epidemiology/psychology
MH  - Cross-Sectional Studies
MH  - Decision Making/*ethics
MH  - *Family
MH  - Female
MH  - Follow-Up Studies
MH  - Germany/epidemiology
MH  - Health Care Surveys
MH  - Humans
MH  - Legal Guardians/*psychology
MH  - Male
MH  - Middle Aged
MH  - Morbidity/trends
MH  - *Patient Compliance
MH  - *Physician-Patient Relations
EDAT- 2011/11/19 06:00
MHDA- 2012/01/13 06:00
CRDT- 2011/11/19 06:00
PHST- 2011/11/19 06:00 [entrez]
PHST- 2011/11/19 06:00 [pubmed]
PHST- 2012/01/13 06:00 [medline]
AID - 10.1111/j.1532-5415.2011.03661.x [doi]
PST - ppublish
SO  - J Am Geriatr Soc. 2011 Nov;59(11):2045-52. doi: 10.1111/j.1532-5415.2011.03661.x.
      Epub 2011 Oct 22.


PMID- 22091827
OWN - NLM
STAT- MEDLINE
DCOM- 20120213
LR  - 20211021
IS  - 1532-5415 (Electronic)
IS  - 0002-8614 (Linking)
VI  - 59
IP  - 12
DP  - 2011 Dec
TI  - When doctors and daughters disagree: twenty-two days and two blinks of an eye.
PG  - 2337-40
LID - 10.1111/j.1532-5415.2011.03700.x [doi]
AB  - A cornerstone of American medical ethics is the right to say, "Keep your hands
      off of me," to decline medical treatment. A central problem is how to decide
      about individuals who have become incapacitated and can no longer request or
      refuse potentially life-sustaining treatment. An advance directive is a formal
      attempt to protect people's right to autonomy when they are no longer autonomous.
      As such, it assumes that previously expressed wishes are precise and immutable,
      but many families make decisions together, and individuals may negotiate,
      compromise, and modify their genuine preferences, especially when novel threats
      arise, and the stakes are high. The current article describes a case in which two
      daughters overruled a patient's explicit preference to refuse life-sustaining
      treatment, leading to burdensome illness before death. In the end, the mother
      seemed to understand her children's needs and seemed willing, at least in
      retrospect, to have met those needs. After the death of this individual, we
      continued to talk with the daughters and videotaped an interview in which they
      shared their perspectives on the case. The daughters consented to be videotaped
      and to share the video with the medical community (available in online version of
      article). Their forceful devotion to their mother and their search in retrospect 
      for what could have been done differently has completely changed our
      understanding of events. We believe that the daughters' behavior is not the
      indefensible breach of respect for person that it seemed to be. Their mother's
      true wishes might well have included a desire to help her children during her own
      dying. Family members' preferences are likely to be important considerations for 
      many people, although the possibility of coercion has to be acknowledged as well.
      Accommodating this level of decision-making complexity is highly problematic for 
      our understanding of advance directives.
CI  - (c) 2011, Copyright the Authors Journal compilation (c) 2011, The American
      Geriatrics Society.
FAU - Abadir, Peter M
AU  - Abadir PM
AD  - Division of Geriatric Medicine and Gerontology, School of Medicine, Johns Hopkins
      University, Baltimore, Maryland, USA.
FAU - Finucane, Thomas E
AU  - Finucane TE
FAU - McNabney, Matthew K
AU  - McNabney MK
LA  - eng
GR  - K23 AG035005/AG/NIA NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
DEP - 20111108
PL  - United States
TA  - J Am Geriatr Soc
JT  - Journal of the American Geriatrics Society
JID - 7503062
SB  - IM
CIN - J Am Geriatr Soc. 2011 Dec;59(12):2366-8. PMID: 22188079
MH  - *Advance Directive Adherence/ethics
MH  - Aged, 80 and over
MH  - *Dissent and Disputes
MH  - Female
MH  - Humans
MH  - Life Support Care/ethics
MH  - Nuclear Family
MH  - Time Factors
PMC - PMC3797145
MID - NIHMS503968
EDAT- 2011/11/19 06:00
MHDA- 2012/02/14 06:00
CRDT- 2011/11/19 06:00
PHST- 2011/11/19 06:00 [entrez]
PHST- 2011/11/19 06:00 [pubmed]
PHST- 2012/02/14 06:00 [medline]
AID - 10.1111/j.1532-5415.2011.03700.x [doi]
PST - ppublish
SO  - J Am Geriatr Soc. 2011 Dec;59(12):2337-40. doi: 10.1111/j.1532-5415.2011.03700.x.
      Epub 2011 Nov 8.


PMID- 22091309
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111123
LR  - 20220408
IS  - 1735-7136 (Electronic)
IS  - 1735-1995 (Linking)
VI  - 16
IP  - 6
DP  - 2011 Jun
TI  - The effect of psychiatric symptoms on the internet addiction disorder in
      Isfahan's University students.
PG  - 793-800
AB  - BACKGROUND: Internet addiction disorder is an interdisciplinary phenomenon and it
      has been studied from different viewpoints in terms of various sciences such as
      medicine, computer, sociology, law, ethics, and psychology. The aim of this study
      was to determine the association of psychiatric symptoms with Internet addiction 
      while controlling for the effects of age, gender, marital status, and educational
      levels. It is hypothesized, that high levels of Internet addiction are associated
      with psychiatric symptoms and are specially correlated with obsessive-compulsive 
      disorder symptoms. METHODS: In a cross-sectional study, a total number of 250
      students from Isfahan's universities were randomly selected. Subjects completed
      the demographic questionnaire, the Young Diagnostic Questionnaire (YDQ) and the
      Symptom Checklist-90-Revision (SCL-90-R). Data was analyzed using the multiple
      logistic regression method. RESULTS: There was an association between psychiatric
      symptoms such as somatization, sensitivity, depression, anxiety, aggression,
      phobias, and psychosis with exception of paranoia; and diagnosis of Internet
      addiction controlling for age, sex, education level, marital status, and type of 
      universities. CONCLUSIONS: A great percentage of youths in the population suffer 
      from the adverse effects of Internet addiction. It is necessary for psychiatrists
      and psychologists to be aware of the mental problems caused by Internet
      addiction.
FAU - Alavi, Seyyed Salman
AU  - Alavi SS
AD  - Management and Medical Informatics Faculty, Isfahan University of Medical
      Sciences, Isfahan, Iran.
FAU - Maracy, Mohammad Reza
AU  - Maracy MR
FAU - Jannatifard, Fereshte
AU  - Jannatifard F
FAU - Eslami, Mehdi
AU  - Eslami M
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Res Med Sci
JT  - Journal of research in medical sciences : the official journal of Isfahan
      University of Medical Sciences
JID - 101235599
PMC - PMC3214398
OTO - NOTNLM
OT  - Internet Addiction
OT  - Internet Users
OT  - Psychiatric Symptoms
EDAT- 2011/11/18 06:00
MHDA- 2011/11/18 06:01
CRDT- 2011/11/18 06:00
PHST- 2011/02/02 00:00 [received]
PHST- 2011/05/31 00:00 [accepted]
PHST- 2011/11/18 06:00 [entrez]
PHST- 2011/11/18 06:00 [pubmed]
PHST- 2011/11/18 06:01 [medline]
PST - ppublish
SO  - J Res Med Sci. 2011 Jun;16(6):793-800.


PMID- 22091250
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111123
LR  - 20220330
IS  - 1735-7136 (Electronic)
IS  - 1735-1995 (Linking)
VI  - 16
IP  - 3
DP  - 2011 Mar
TI  - Situation analysis of local ethical committees in medical sciences in Iran.
PG  - 310-5
AB  - BACKGROUND: Local ethical committees in medical sciences in Iran were established
      in 1999 in order to assess and evaluate the observance of ethical standards
      throughout the universities and research centers. The purpose of this study is to
      analyze the situation of local ethical committees in order to develop research
      ethics guideline. METHODS: For this cross-sectional study which has been
      conducted with the support of WHO, 40 local ethical committees in all
      universities of medical sciences were evaluated by use of determined
      questionnaires. RESULTS: In this study, 40 universities of medical sciences
      participated; all of them have established local ethical committees. Each
      committee has 5 to 11 members and in more than 80% cases, written guidelines for 
      selecting the committee's members are available. The minimum number of members
      for official session is at least 3 and replacement of absent members, did not
      take place in more than 85% of the committees. Informed consent in 95% of these
      local ethical committees is available. In all committees, researches regarding
      the use of human subjects are under ethical consideration. In half of the local
      ethical committees, penalties for non-compliance with the regulations are
      considered. The average number of research project evaluated in last session of
      these committees was 15.2 and the committees in 50% of cases have provided ethics
      training specifically for their members. CONCLUSIONS: Policymakers should develop
      a standard guideline for local ethical committees in medical science universities
      in Iran.
FAU - Fakour, Yousef
AU  - Fakour Y
AD  - Associate Professor, Undersecretary of Research and Technology, Ministry of
      Health and Medical Education, Tehran, Iran.
FAU - Eftekhari, Monir Baradaran
AU  - Eftekhari MB
FAU - Haghighi, Zohre
AU  - Haghighi Z
FAU - Mehr, Najmeh Khosravan
AU  - Mehr NK
FAU - Hejazi, Farzaneh
AU  - Hejazi F
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Res Med Sci
JT  - Journal of research in medical sciences : the official journal of Isfahan
      University of Medical Sciences
JID - 101235599
PMC - PMC3214339
OTO - NOTNLM
OT  - Ethics Committees
OT  - Iran
OT  - Medical Sciences
OT  - Situation Analysis
EDAT- 2011/11/18 06:00
MHDA- 2011/11/18 06:01
CRDT- 2011/11/18 06:00
PHST- 2010/08/08 00:00 [received]
PHST- 2010/10/13 00:00 [accepted]
PHST- 2011/11/18 06:00 [entrez]
PHST- 2011/11/18 06:00 [pubmed]
PHST- 2011/11/18 06:01 [medline]
PST - ppublish
SO  - J Res Med Sci. 2011 Mar;16(3):310-5.


PMID- 22090422
OWN - NLM
STAT- MEDLINE
DCOM- 20120705
LR  - 20211203
IS  - 1460-2083 (Electronic)
IS  - 0964-6906 (Linking)
VI  - 21
IP  - 5
DP  - 2012 Mar 1
TI  - Tuberin and PRAS40 are anti-apoptotic gatekeepers during early human amniotic
      fluid stem-cell differentiation.
PG  - 1049-61
LID - 10.1093/hmg/ddr535 [doi]
AB  - Embryoid bodies (EBs) are three-dimensional multicellular aggregates allowing the
      in vitro investigation of stem-cell differentiation processes mimicking early
      embryogenesis. Human amniotic fluid stem (AFS) cells harbor high proliferation
      potential, do not raise the ethical issues of embryonic stem cells, have a lower 
      risk for tumor development, do not need exogenic induction of pluripotency and
      are chromosomal stable. Starting from a single human AFS cell, EBs can be formed 
      accompanied by the differentiation into cells of all three embryonic germ layers.
      Here, we report that siRNA-mediated knockdown of the endogenous tuberous
      sclerosis complex-2 (TSC2) gene product tuberin or of proline-rich Akt substrate 
      of 40 kDa (PRAS40), the two major negative regulators of mammalian target of
      rapamycin (mTOR), leads to massive apoptotic cell death during EB development of 
      human AFS cells without affecting the endodermal, mesodermal and ectodermal cell 
      differentiation spectrum. Co-knockdown of endogenous mTOR demonstrated these
      effects to be mTOR-dependent. Our findings prove this enzyme cascade to be an
      essential anti-apoptotic gatekeeper of stem-cell differentiation during EB
      formation. These data allow new insights into the regulation of early stem-cell
      maintenance and differentiation and identify a new role of the tumor suppressor
      tuberin and the oncogenic protein PRAS40 with the relevance for a more detailed
      understanding of the pathogenesis of diseases associated with altered activities 
      of these gene products.
FAU - Fuchs, Christiane
AU  - Fuchs C
AD  - Institute of Medical Genetics, Medical University of Vienna, Wahringer Strasse
      10, Vienna 1090, Austria.
FAU - Rosner, Margit
AU  - Rosner M
FAU - Dolznig, Helmut
AU  - Dolznig H
FAU - Mikula, Mario
AU  - Mikula M
FAU - Kramer, Nina
AU  - Kramer N
FAU - Hengstschlager, Markus
AU  - Hengstschlager M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111116
PL  - England
TA  - Hum Mol Genet
JT  - Human molecular genetics
JID - 9208958
RN  - 0 (AKT1S1 protein, human)
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (RNA, Small Interfering)
RN  - 0 (TSC2 protein, human)
RN  - 0 (Tuberous Sclerosis Complex 2 Protein)
RN  - 0 (Tumor Suppressor Proteins)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing/genetics/*metabolism
MH  - Amniotic Fluid/*cytology
MH  - *Apoptosis
MH  - *Cell Differentiation
MH  - Cell Line
MH  - Cell Line, Tumor
MH  - Down-Regulation
MH  - Embryoid Bodies/cytology/physiology
MH  - Germ Layers/cytology
MH  - Humans
MH  - Pluripotent Stem Cells/*cytology/*physiology
MH  - RNA, Small Interfering
MH  - TOR Serine-Threonine Kinases/metabolism
MH  - Tuberous Sclerosis Complex 2 Protein
MH  - Tumor Suppressor Proteins/genetics/*metabolism
EDAT- 2011/11/18 06:00
MHDA- 2012/07/06 06:00
CRDT- 2011/11/18 06:00
PHST- 2011/11/18 06:00 [entrez]
PHST- 2011/11/18 06:00 [pubmed]
PHST- 2012/07/06 06:00 [medline]
AID - ddr535 [pii]
AID - 10.1093/hmg/ddr535 [doi]
PST - ppublish
SO  - Hum Mol Genet. 2012 Mar 1;21(5):1049-61. doi: 10.1093/hmg/ddr535. Epub 2011 Nov
      16.


PMID- 22090342
OWN - NLM
STAT- MEDLINE
DCOM- 20120727
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 17
IP  - 4
DP  - 2011 Dec
TI  - Nanoethics and the breaching of boundaries: a heuristic for going from
      encouragement to a fuller integration of ethical, legal and social issues and
      science : commentary on: "Adding to the mix: integrating ELSI into a National
      Nanoscale Science and Technology Center".
PG  - 761-7
LID - 10.1007/s11948-011-9322-y [doi]
AB  - The intersection of ELSI and science forms a complicated nexus yet their
      integration is an important goal both for society and for the successful
      advancement of science. In what follows, I present a heuristic that makes
      boundary identification and crossing an important tool in the discovery of
      potential areas of ethical, legal, and social concern in science. A dynamic and
      iterative application of the heuristic can lead towards a fuller integration and 
      appreciation of the concerns of ELSI and of science from both sides of the
      divide.
FAU - Tuma, Julio R
AU  - Tuma JR
AD  - Philosophy Department, Division of Humanities, University of Chicago, 1115 East
      58th Street, Chicago, IL 60637, USA. jrtuma@uchicago.edu
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20111117
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
CON - Sci Eng Ethics. 2011 Dec;17(4):743-60. PMID: 22068631
MH  - *Ethics, Research
MH  - Humans
MH  - Nanotechnology/*ethics
MH  - *Public Policy
MH  - *Social Values
EDAT- 2011/11/18 06:00
MHDA- 2012/07/28 06:00
CRDT- 2011/11/18 06:00
PHST- 2009/08/27 00:00 [received]
PHST- 2011/09/29 00:00 [accepted]
PHST- 2011/11/18 06:00 [entrez]
PHST- 2011/11/18 06:00 [pubmed]
PHST- 2012/07/28 06:00 [medline]
AID - 10.1007/s11948-011-9322-y [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2011 Dec;17(4):761-7. doi: 10.1007/s11948-011-9322-y. Epub 2011
      Nov 17.


PMID- 22090016
OWN - NLM
STAT- MEDLINE
DCOM- 20120611
LR  - 20211021
IS  - 1433-0385 (Electronic)
IS  - 0009-4722 (Linking)
VI  - 82
IP  - 12
DP  - 2011 Dec
TI  - [Contribution of the Study Center of the German Surgical Society to evidence
      based surgery].
PG  - 1109-15
LID - 10.1007/s00104-011-2121-9 [doi]
AB  - Since the Study Center of the German Surgical Society (SDGC) was established in
      2003 it has been supporting surgeons to implement their ideas for multicenter
      randomized studies. Assistance is provided for development (sample size
      calculation, protocol, funding application) implementation (submission to ethics 
      committee, data management, monitoring) and analysis (statistical analysis,
      publication) in close collaboration with biometricians and data managers.
      Currently more than 2,500 patients have been included in 11 trials. The most
      complex SDGC study (SYNCHRONOUS) so far with up to 80 participating centers has
      been activated in September 2011. Furthermore, there is an increasing relevance
      for systematic reviews and meta analyses with regard to the development of
      studies and aggregation of results. For this reason a systematic review working
      group was established within the SDGC. To date 13 publications have been
      completed and 8 more are underway.
FAU - Fink, C
AU  - Fink C
AD  - Studienzentrum der Deutschen Gesellschaft fur Chirurgie, Heidelberg, Germany.
FAU - Keck, T
AU  - Keck T
FAU - Rossion, I
AU  - Rossion I
FAU - Weitz, J
AU  - Weitz J
FAU - Diener, M K
AU  - Diener MK
FAU - Buchler, M W
AU  - Buchler MW
FAU - Knebel, P
AU  - Knebel P
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Beitrag des Studienzentrums der Deutschen Gesellschaft fur Chirurgie zur
      evidenzbasierten Chirurgie.
PL  - Germany
TA  - Chirurg
JT  - Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
JID - 16140410R
SB  - IM
MH  - *Evidence-Based Medicine
MH  - Germany
MH  - Humans
MH  - Multicenter Studies as Topic
MH  - Randomized Controlled Trials as Topic
MH  - Research Design
MH  - Research Support as Topic
MH  - *Societies, Medical
EDAT- 2011/11/18 06:00
MHDA- 2012/06/12 06:00
CRDT- 2011/11/18 06:00
PHST- 2011/11/18 06:00 [entrez]
PHST- 2011/11/18 06:00 [pubmed]
PHST- 2012/06/12 06:00 [medline]
AID - 10.1007/s00104-011-2121-9 [doi]
PST - ppublish
SO  - Chirurg. 2011 Dec;82(12):1109-15. doi: 10.1007/s00104-011-2121-9.


PMID- 22089656
OWN - NLM
STAT- MEDLINE
DCOM- 20120313
LR  - 20191210
IS  - 1948-965X (Electronic)
IS  - 1682-3141 (Linking)
VI  - 19
IP  - 4
DP  - 2011 Dec
TI  - A computer literacy scale for newly enrolled nursing college students:
      development and validation.
PG  - 305-17
LID - 10.1097/JNR.0b013e318236d03f [doi]
AB  - BACKGROUND: Increasing application and use of information systems and mobile
      technologies in the healthcare industry require increasing nurse competency in
      computer use. Computer literacy is defined as basic computer skills, whereas
      computer competency is defined as the computer skills necessary to accomplish job
      tasks. Inadequate attention has been paid to computer literacy and computer
      competency scale validity. PURPOSE: This study developed a computer literacy
      scale with good reliability and validity and investigated the current computer
      literacy of newly enrolled students to develop computer courses appropriate to
      students' skill levels and needs. METHODS: This study referenced Hinkin's process
      to develop a computer literacy scale. Participants were newly enrolled first-year
      undergraduate students, with nursing or nursing-related backgrounds, currently
      attending a course entitled Information Literacy and Internet Applications.
      Researchers examined reliability and validity using confirmatory factor analysis.
      RESULTS: The final version of the developed computer literacy scale included six 
      constructs (software, hardware, multimedia, networks, information ethics, and
      information security) and 22 measurement items. Confirmatory factor analysis
      showed that the scale possessed good content validity, reliability, convergent
      validity, and discriminant validity. This study also found that participants
      earned the highest scores for the network domain and the lowest score for the
      hardware domain. CONCLUSIONS/IMPLICATIONS FOR PRACTICE: With increasing use of
      information technology applications, courses related to hardware topic should be 
      increased to improve nurse problem-solving abilities. This study recommends that 
      emphases on word processing and network-related topics may be reduced in favor of
      an increased emphasis on database, statistical software, hospital information
      systems, and information ethics.
FAU - Lin, Tung-Cheng
AU  - Lin TC
AD  - Department of Information Management, National Taipei University of Nursing and
      Health Sciences.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
PL  - China (Republic : 1949- )
TA  - J Nurs Res
JT  - The journal of nursing research : JNR
JID - 101128757
SB  - IM
MH  - *Computer Literacy
MH  - Humans
MH  - *Students, Nursing
EDAT- 2011/11/18 06:00
MHDA- 2012/03/14 06:00
CRDT- 2011/11/18 06:00
PHST- 2011/11/18 06:00 [entrez]
PHST- 2011/11/18 06:00 [pubmed]
PHST- 2012/03/14 06:00 [medline]
AID - 10.1097/JNR.0b013e318236d03f [doi]
AID - 00134372-201112000-00010 [pii]
PST - ppublish
SO  - J Nurs Res. 2011 Dec;19(4):305-17. doi: 10.1097/JNR.0b013e318236d03f.


PMID- 22089619
OWN - NLM
STAT- MEDLINE
DCOM- 20120315
LR  - 20211021
IS  - 0971-5916 (Print)
IS  - 0971-5916 (Linking)
VI  - 134
DP  - 2011 Oct
TI  - Ethical issues in genetic counselling with special reference to
      haemoglobinopathies.
PG  - 547-51
AB  - Genetic counselling is provided in places where genetic tests are carried out.
      The process involves pre-test counselling as well as post-test counselling to
      enable the individuals to face the situation and take appropriate decisions with 
      the right frame of mind. Major ethical principles which govern the attitudes and 
      actions of counsellors include: respect for patient autonomy, non-maleficence,
      beneficence, or taking action to help benefit others and prevent harm, both
      physical and mental, and justice, which requires that services be distributed
      fairly to those in need. Other moral issues include veracity, the duty to
      disclose information or to be truthful, and respect for patient confidentiality. 
      Nondirective counselling, a hallmark of this profession, is in accordance with
      the principle of individual autonomy. High prevalence of haemoglobinopathies with
      availability of good and sensitive carrier detection tests and prenatal
      diagnostic techniques makes these good candidates for population screening of
      carriers along with genetic counselling for primary prevention of the disease.
      Screening of the extended family members of the affected child, high risk
      communities and general population screening including antenatal women are the
      main target groups for planning a Haemoglobinopathy control programme. A critical
      mass of trained genetic counsellors who have understanding of the ethical issues 
      and its appropriate handling with the required sensitivity is needed in India.
FAU - Muthuswamy, Vasantha
AU  - Muthuswamy V
AD  - 5/1 (Old), 8/1 (new), Padmalaya Apartments, Balakrishnan Road, Valmiki Nagar,
      Thiruvanmiyur, Chennai, India. vmuthuswamy@hotmail.com
LA  - eng
PT  - Journal Article
PT  - Review
PL  - India
TA  - Indian J Med Res
JT  - The Indian journal of medical research
JID - 0374701
SB  - IM
MH  - Confidentiality/ethics
MH  - Female
MH  - Genetic Carrier Screening
MH  - Genetic Counseling/*ethics
MH  - Genetic Testing/*ethics
MH  - Hemoglobinopathies/*diagnosis/genetics
MH  - Humans
MH  - India
MH  - Patient Rights/*ethics
MH  - Pregnancy
MH  - Prenatal Diagnosis/*ethics
PMC - PMC3237255
EDAT- 2011/11/18 06:00
MHDA- 2012/03/16 06:00
CRDT- 2011/11/18 06:00
PHST- 2011/11/18 06:00 [entrez]
PHST- 2011/11/18 06:00 [pubmed]
PHST- 2012/03/16 06:00 [medline]
AID - IndianJMedRes_2011_134_4_547_89904 [pii]
PST - ppublish
SO  - Indian J Med Res. 2011 Oct;134:547-51.


PMID- 22089545
OWN - NLM
STAT- MEDLINE
DCOM- 20120413
LR  - 20131121
IS  - 1791-244X (Electronic)
IS  - 1107-3756 (Linking)
VI  - 29
IP  - 2
DP  - 2012 Feb
TI  - Parthenogenetic embryonic stem cells with H19 siRNA-mediated knockdown as a
      potential resource for cell therapy.
PG  - 257-62
LID - 10.3892/ijmm.2011.838 [doi]
AB  - Embryonic stem (ES) cells are used in cell therapy and tissue engineering due to 
      their ability to produce different cells types. However, studies of ES cells that
      are derived from fertilized embryos have raised concerns about the limitations
      imposed by ethical and political considerations. Therefore, many studies of stem 
      cells use the stem cells that are derived from unfertilized oocytes and adult
      tissue. Although parthenogenetic embryonic stem (ESP) cells also avoid ethical
      and political dilemmas and can be used in cell-based therapy, the ESP cells
      exhibit growth retardation problems. Therefore, to investigate the potential for 
      muscle growth from genetically modified ESP cells, we established four ES cell
      types, including normal embryonic stem (ESN) cells, ESP cells, ESP cells that
      overexpress the insulin-like growth factor 2 (Igf2) gene (ESI) and ESP cells with
      down-regulated H19 gene expression (ESH). Using these cells, we examined the
      expression profiles of genes that were related to imprinting and muscle using
      microarrays. The gene expression patterns of ESI and ESH cells were similar and
      were more closely related to the ESN pattern than that of the ESP cells.
      Differentiated ESH cells exhibited increased expression of bone morphologic
      protein 4 (BMP4), which is a mesoderm marker, compared with the differentiated
      ESI cells. We showed that Igf2 expression was induced by H19 silencing in the ESP
      cells via hypermethylation of the H19 imprinting control region 1 (ICR1).
      Moreover, the proportion of ESH-derived chimera was slightly higher than those
      produced from the ESP cells. In addition, we detected increased cell
      proliferation in the MEF cells following H19 knock-down. These results indicate
      that the ESH cells may be a source of cell-based therapy for conditions such as
      muscular atrophy.
FAU - Kwak, Minhye
AU  - Kwak M
AD  - Ilchun Genomic Medicine Institute, MRC, Department of Biochemistry and Molecular 
      Biology, Seoul National University College of Medicine, Seoul 110-799, Republic
      of Korea.
FAU - Hong, Su
AU  - Hong S
FAU - Yu, Seong-Lan
AU  - Yu SL
FAU - Sim, Bo-Woong
AU  - Sim BW
FAU - Seo, Jeong-Sun
AU  - Seo JS
FAU - Kang, Jaeku
AU  - Kang J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111115
PL  - Greece
TA  - Int J Mol Med
JT  - International journal of molecular medicine
JID - 9810955
RN  - 0 (H19 long non-coding RNA)
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (RNA, Small Interfering)
RN  - 0 (RNA, Untranslated)
RN  - 67763-97-7 (Insulin-Like Growth Factor II)
SB  - IM
MH  - Animals
MH  - Chimera
MH  - Cluster Analysis
MH  - DNA Methylation
MH  - Embryonic Stem Cells/*metabolism/transplantation
MH  - Female
MH  - Fibroblasts/enzymology/metabolism
MH  - Gene Expression
MH  - Gene Expression Regulation
MH  - Gene Order
MH  - Genetic Vectors/genetics
MH  - Genomic Imprinting
MH  - Insulin-Like Growth Factor II/genetics/metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred DBA
MH  - Muscular Dystrophies/genetics/metabolism/therapy
MH  - *Parthenogenesis
MH  - *RNA Interference
MH  - RNA, Long Noncoding
MH  - *RNA, Small Interfering/metabolism
MH  - RNA, Untranslated/*genetics/metabolism
EDAT- 2011/11/18 06:00
MHDA- 2012/04/14 06:00
CRDT- 2011/11/18 06:00
PHST- 2011/09/09 00:00 [received]
PHST- 2011/10/31 00:00 [accepted]
PHST- 2011/11/18 06:00 [entrez]
PHST- 2011/11/18 06:00 [pubmed]
PHST- 2012/04/14 06:00 [medline]
AID - 10.3892/ijmm.2011.838 [doi]
PST - ppublish
SO  - Int J Mol Med. 2012 Feb;29(2):257-62. doi: 10.3892/ijmm.2011.838. Epub 2011 Nov
      15.


PMID- 22088813
OWN - NLM
STAT- MEDLINE
DCOM- 20120409
LR  - 20120214
IS  - 1532-7361 (Electronic)
IS  - 0039-6060 (Linking)
VI  - 151
IP  - 3
DP  - 2012 Mar
TI  - Incisional hernia after abdominal closure with slowly absorbable versus fast
      absorbable, antibacterial-coated sutures.
PG  - 398-403
LID - 10.1016/j.surg.2011.08.004 [doi]
AB  - BACKGROUND: Incisional hernia remains among the most common complications after
      midline incision of the abdominal wall. The role of the suture material used for 
      abdominal wall closure remains controversial. To decrease bacterial adherence to 
      surgical sutures, braided suture materials with antibacterial activity (Vicryl
      plus, Ethicon, Inc) were developed. This is the first study to analyze long-term 
      results using an antibacterial-braided suture material for abdominal wall closure
      in a large clinical trial. METHODS: To analyze the effects of Triclosan-coated
      suture material (Vicryl plus) on the development of incisional hernia, we
      performed a 36-month follow-up of 1,018 patients who had a primary midline
      incision for elective abdominal surgery. In the first time period, a PDS II loop 
      suture was used. In the second observation period, we used Vicryl plus. All
      variables were recorded prospectively in a database. The primary outcome was the 
      number of incisional hernias. Risk factors for the development of incisional
      hernias were collected prospectively to compare the 2 groups. RESULTS: The
      overall incisional hernia rate in the 36-month follow-up period was 14.6%.
      Analyzing the influence of the suture material used on the development of
      incisional hernia, we did not find differences between the 2 groups (PDS II, 14%;
      Vicryl plus, 15.2%). In the multivariate analysis of possible factors in the
      study population, only body mass index (BMI) showed a significant influence on
      the development of incisional hernias. Despite the incidence of wound infections 
      being less in the Vicryl plus group (6.1% vs 11.9%; P < .05), there were no
      difference in incidence of incisional hernia between the 2 groups. CONCLUSION:
      Fast absorbable sutures with antibacterial coating (Tricosan) do not increase the
      hernia rate after midline abdominal incision compared with slowly absorbable
      sutures, when wound infection rates are decreased by coating the fast absorbable 
      suture with Triclosan. The development of incisional hernia is significantly
      increasing in patients with a BMI >30 kg/m(2).
CI  - Copyright A(c) 2012 Mosby, Inc. All rights reserved.
FAU - Justinger, Christoph
AU  - Justinger C
AD  - Department of General, Visceral, Vascular and Paediatric Surgery, University of
      the Saarland, Homburg/Saar, Germany.
FAU - Slotta, Jan Erik
AU  - Slotta JE
FAU - Schilling, Martin Karl
AU  - Schilling MK
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20111116
PL  - United States
TA  - Surgery
JT  - Surgery
JID - 0417347
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Coated Materials, Biocompatible)
RN  - 31621-87-1 (Polydioxanone)
RN  - 34346-01-5 (Polyglactin 910)
SB  - IM
MH  - Abdominal Wall/surgery
MH  - Abdominal Wound Closure Techniques/*adverse effects
MH  - Absorption
MH  - Aged
MH  - Anti-Bacterial Agents/administration & dosage
MH  - Coated Materials, Biocompatible
MH  - Female
MH  - Follow-Up Studies
MH  - Hernia, Abdominal/*etiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polydioxanone/adverse effects
MH  - Polyglactin 910/adverse effects
MH  - Prospective Studies
MH  - Risk Factors
MH  - Sutures/*adverse effects
EDAT- 2011/11/18 06:00
MHDA- 2012/04/10 06:00
CRDT- 2011/11/18 06:00
PHST- 2011/03/02 00:00 [received]
PHST- 2011/08/04 00:00 [accepted]
PHST- 2011/11/18 06:00 [entrez]
PHST- 2011/11/18 06:00 [pubmed]
PHST- 2012/04/10 06:00 [medline]
AID - S0039-6060(11)00470-3 [pii]
AID - 10.1016/j.surg.2011.08.004 [doi]
PST - ppublish
SO  - Surgery. 2012 Mar;151(3):398-403. doi: 10.1016/j.surg.2011.08.004. Epub 2011 Nov 
      16.


PMID- 22088540
OWN - NLM
STAT- MEDLINE
DCOM- 20120504
LR  - 20220317
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Linking)
VI  - 124
IP  - 20
DP  - 2011 Oct
TI  - Microwave ablation: results in ex vivo and in vivo porcine livers with 2450-MHz
      cooled-shaft antenna.
PG  - 3386-93
AB  - BACKGROUND: Imaging-guided thermal ablation using different energy sources
      continues to gain favor as a minimally invasive technique for the treatment of
      primary and metastatic hepatic malignant tumors. This study aimed to evaluate the
      performance of microwave ablation with 2450-MHz internally cooled-shaft antenna
      in ex vivo and in vivo porcine livers. METHODS: All studies were animal care and 
      ethics committee approved. Microwave ablation was performed using a noncooled or 
      cooled-shaft antenna in 23 ex vivo (92 ablations) and eight in vivo (36
      ablations) porcine livers. Diameters of the coagulation zone were observed on
      gross specimens. The coagulation diameters achieved in different microwave
      ablation parameter groups were compared. Curve estimation analysis was performed 
      to characterize the relationship between applied power and treatment duration and
      coagulation diameter (including short-axis and long-axis diameter). RESULTS:
      Coagulation zones were elliptical and an arrowed-shaped carbonization zone around
      the shaft was observed in all groups. But the antenna track was also coagulated
      in the noncooled-shaft antenna groups. In ex vivo livers, the short-axis diameter
      correlated with the power output in a quadratic curve fashion (R(2) = 0.95) by
      fixing ablation duration to 10 minutes, and correlated with the ablation duration
      in a logarithmic curve fashion (R(2) = 0.98) by fixing power output to 80 W. The 
      short-axis reached a relative plateau within 25 minutes. In in vivo livers,
      short-axis diameter correlated with the coagulation duration in a sigmoidal curve
      fashion (60 W group R(2) = 0.76, 80 W group R(2) = 0.87), with a relative plateau
      achieved within 10 minutes for power settings of 60 W and 80 W. CONCLUSIONS: The 
      internally cooled microwave antenna may be advantageous to minimize collateral
      damage. The short-axis diameter enlargement has a plateau by fixing power output.
FAU - Zhou, Qi
AU  - Zhou Q
AD  - Department of Hepatobiliary Surgery, First Affiliated Hospital, Sun Yat-sen
      University, Guangzhou, Guangdong 510080, China.
FAU - Jin, Xing
AU  - Jin X
FAU - Jiao, De-Chao
AU  - Jiao DC
FAU - Zhang, Fu-Jun
AU  - Zhang FJ
FAU - Zhang, Liang
AU  - Zhang L
FAU - Han, Xin-Wei
AU  - Han XW
FAU - Duan, Guang-Feng
AU  - Duan GF
FAU - Han, Jian-Jun
AU  - Han JJ
FAU - Li, Chuan-Xing
AU  - Li CX
LA  - eng
PT  - Journal Article
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
SB  - IM
MH  - Animals
MH  - *Catheter Ablation
MH  - Liver/surgery
MH  - *Microwaves
MH  - Swine
EDAT- 2011/11/18 06:00
MHDA- 2012/05/05 06:00
CRDT- 2011/11/18 06:00
PHST- 2011/11/18 06:00 [entrez]
PHST- 2011/11/18 06:00 [pubmed]
PHST- 2012/05/05 06:00 [medline]
PST - ppublish
SO  - Chin Med J (Engl). 2011 Oct;124(20):3386-93.


PMID- 22088234
OWN - NLM
STAT- MEDLINE
DCOM- 20120320
LR  - 20130520
IS  - 1533-9866 (Electronic)
IS  - 0029-7828 (Linking)
VI  - 66
IP  - 9
DP  - 2011 Sep
TI  - Ethical concerns and career satisfaction in obstetrics and gynecology: a review
      of recent findings from the Collaborative Ambulatory Research Network.
PG  - 572-9
LID - 10.1097/OGX.0b013e3182391240 [doi]
AB  - UNLABELLED: Obstetricians-gynecologists (ob-gyns) are frequently confronted with 
      situations that have ethical implications (e.g., whether to accept gifts or
      samples from drug companies or disclosing medical errors to patients).
      Additionally, various factors, including specific job-related tasks, costs, and
      benefits, may impact ob-gyns' career satisfaction. Ethical concerns and career
      satisfaction can play a role in the quality of women's health care. This article 
      summarizes the studies published between 2005 and 2009 by the Research Department
      of the American College of Obstetricians and Gynecologists, which encompass
      ethical concerns regarding interactions with pharmaceutical representatives and
      patient safety/medical error reporting, as well as ob-gyn career satisfaction.
      Additionally, a brief discussion regarding ethical concerns in the ob-gyn field, 
      in general, highlights key topics for the last 30 years. Ethical dilemmas
      continue to be of concern for ob-gyns. Familiarity with guidelines on appropriate
      interactions with industry is associated with lower percentages of potentially
      problematic relationships with pharmaceutical industries. Physicians report that 
      the expense of patient safety initiatives is one of the top barriers for
      improving patient safety, followed by fear of liability. Overall, respondents
      reported being satisfied with their careers. However, half of the respondents
      reported that they were extremely concerned about the impact of professional
      liability costs on the duration of their careers. Increased familiarity with
      guidelines may lead to a decreased ob-gyn reliance on pharmaceutical
      representatives and free samples, whereas specific and practical tools may help
      them implement patient safety techniques. The easing of malpractice insurance and
      threat of litigation may enhance career satisfaction among ob-gyns. This article 
      will discuss related findings in recent years. TARGET AUDIENCE: Obstetricians &
      Gynecologists and Family Physicians. LEARNING OBJECTIVES: After the completing
      the CME activity, physicians should be better able to analyze how interactions
      with pharmaceutical industry may pose ethical dilemmas, examine current barriers 
      to implementing patient safety initiatives, and evaluate the factors that
      influence career satisfaction among obstetrician-gynecologists.
FAU - Farrow, Victoria A
AU  - Farrow VA
AD  - American College of Obstetricians and Gynecologists, Washington, DC 20024, USA.
FAU - Leddy, Meaghan A
AU  - Leddy MA
FAU - Lawrence, Hal
AU  - Lawrence H
FAU - Schulkin, Jay
AU  - Schulkin J
LA  - eng
GR  - R60-MC-05674/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Obstet Gynecol Surv
JT  - Obstetrical & gynecological survey
JID - 0401007
SB  - IM
MH  - Drug Industry
MH  - Guidelines as Topic
MH  - Gynecology/*ethics
MH  - Humans
MH  - Insurance, Liability
MH  - *Job Satisfaction
MH  - Liability, Legal
MH  - Medical Errors/ethics
MH  - Obstetrics/*ethics
MH  - Patient Safety
MH  - United States
EDAT- 2011/11/18 06:00
MHDA- 2012/03/21 06:00
CRDT- 2011/11/18 06:00
PHST- 2011/11/18 06:00 [entrez]
PHST- 2011/11/18 06:00 [pubmed]
PHST- 2012/03/21 06:00 [medline]
AID - 0006254-201100900-00022 [pii]
AID - 10.1097/OGX.0b013e3182391240 [doi]
PST - ppublish
SO  - Obstet Gynecol Surv. 2011 Sep;66(9):572-9. doi: 10.1097/OGX.0b013e3182391240.


PMID- 22088175
OWN - NLM
STAT- MEDLINE
DCOM- 20120419
LR  - 20160607
IS  - 0578-1310 (Print)
IS  - 0578-1310 (Linking)
VI  - 49
IP  - 7
DP  - 2011 Jul
TI  - [Ethic review of clinical researches in children].
PG  - 485-8
FAU - Pan, Yue-song
AU  - Pan YS
FAU - Du, Zhong-dong
AU  - Du ZD
FAU - Shen, Ying
AU  - Shen Y
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Er Ke Za Zhi
JT  - Zhonghua er ke za zhi = Chinese journal of pediatrics
JID - 0417427
RN  - 0 (Drugs, Investigational)
SB  - IM
MH  - Child
MH  - Clinical Trials as Topic/*ethics
MH  - *Drugs, Investigational
MH  - Humans
EDAT- 2011/11/18 06:00
MHDA- 2012/04/20 06:00
CRDT- 2011/11/18 06:00
PHST- 2011/11/18 06:00 [entrez]
PHST- 2011/11/18 06:00 [pubmed]
PHST- 2012/04/20 06:00 [medline]
PST - ppublish
SO  - Zhonghua Er Ke Za Zhi. 2011 Jul;49(7):485-8.


PMID- 22088160
OWN - NLM
STAT- MEDLINE
DCOM- 20120320
LR  - 20130411
IS  - 1091-3734 (Electronic)
IS  - 1091-3734 (Linking)
VI  - 16
IP  - 2
DP  - 2011 May 10
TI  - Ethics: beyond patient care: practicing empathy in the workplace.
PG  - 11
FAU - Dinkins, Christine Sorrell
AU  - Dinkins CS
AD  - Philosophy Department, Wofford College, Spartanburg, SC, USA.
      Dinkinscs@wofford.edu
LA  - eng
PT  - Journal Article
DEP - 20110510
PL  - United States
TA  - Online J Issues Nurs
JT  - Online journal of issues in nursing
JID - 9806525
SB  - IM
MH  - *Empathy
MH  - *Ethics, Nursing
MH  - Humans
MH  - Nursing Staff/*ethics/*psychology
MH  - *Philosophy, Nursing
MH  - Workplace
EDAT- 2011/11/18 06:00
MHDA- 2012/03/21 06:00
CRDT- 2011/11/18 06:00
PHST- 2011/11/18 06:00 [entrez]
PHST- 2011/11/18 06:00 [pubmed]
PHST- 2012/03/21 06:00 [medline]
AID - Vol-16-2011/No2-May-2011/Empathy-in-the-Workplace.html [pii]
PST - epublish
SO  - Online J Issues Nurs. 2011 May 10;16(2):11.


PMID- 22087458
OWN - NLM
STAT- MEDLINE
DCOM- 20160423
LR  - 20181201
IS  - 1790-5427 (Print)
IS  - 1790-5427 (Linking)
VI  - 14
IP  - 3
DP  - 2011 Sep-Dec
TI  - Comparison between one day and two days protocols for sentinel node mapping of
      breast cancer patients.
PG  - 313-5
AB  - Sentinel node biopsy can decrease the morbidity of breast cancer treatment
      significantly by sparing many patients of axillary lymph node dissection and
      resulting arm lymphedema. Despite widespread use of sentinel node mapping for
      breast cancer patients almost all aspects of this procedure are controversial;
      such as: type of the radiotracer, eligibility, time of injection, etc. One of
      these controversial issues is the efficacy of 2 days protocol (injection of the
      tracer on one day and sentinel node mapping and surgery on the following day).
      The main reason to perform 2 days protocol is the ease of operation room
      scheduling the patient does not need to complete injection and imaging in the
      nuclear medicine department. Despite widespread use of 2 days protocol for
      sentinel node mapping, very few studies have specifically evaluated this protocol
      in comparison to 1 day protocol and also the false negative rate which is the
      better index of sentinel node mapping success. Most of the above studies used
      tracers with large particle size such as (99m)Tc-sulfur colloid. Tracers with
      small particle size can theoretically be washed out from the real sentinel nodes 
      and move to the second echelon nodes, so some recommended using large particle
      size radiotracers for the 2 days protocol. In this study, we compared the false
      negative rate of sentinel node mapping between 1 and 2 days protocols using
      intradermal injection of (99m)Tc-antimony sulfide colloid ((99m)Tc-SbSC) which
      has very small particle size. Eighty patients with early stage breast cancer
      (clinical stages of I and II) were evaluated. The diagnosis of the breast cancer 
      was established by either excisional or core needle biopsy. The patients didn't
      take any chemotherapeutic drug before surgery and were divided into two groups: 1
      day (Group I) and 2 days (Group II) protocols (45 in Group I and 35 in Group II).
      For Group I, periareolar intradermal injections of 0.5Bq/0.2mL (99m)Tc-SbSC were 
      applied for patients without previous excisional biopsy. For patients with
      excisional biopsy two intradermal injections of 0.5Bq/0.2mL (99m)Tc-SbSC were
      used on both sides of the incision line. All injections were followed by gentle
      massage for 1min. For Group II, the same injection techniques were used but the
      dose of the tracer was doubled. Anterior, and lateral spot views were acquired
      30min after the injection (5min/image, 128Chi128 matrix) using a dual head gamma 
      camera (E.CAM Siemens) and parallel hole low energy high resolution collimator.
      The operation was performed 4h (for Group I) or 20h (for Group II) post
      radiotracer injection. All patients received 2mL patent blue V dye in a subdermal
      and periareolar fashion, 2min after general anesthesia. A surgical gamma probe
      (EUROPROBE, France) was used for harvesting the sentinel lymph nodes during
      surgery. As sentinel node was defined any blue node or any node with an ex vivo
      radioisotope count of twofold or greater than the axillary background. After
      completion of sentinel node biopsy, all patients underwent standard axillary
      lymph node dissection. The study was approved by our local ethical committee and 
      all patients gave their informed consent before inclusion into the study.
      Quantitative data were expressed as mean+/-SD. For comparison between groups,
      independent sample student's t-test for quantitative variables, and chi-square or
      Fisher's exact tests for categorical variables were used. P-values less than 0.05
      were considered statistically significant. SPSS version 11.5 was used for
      statistical analyses. The patients characteristics are shown in Table I. These
      general characteristics were not significantly different between the study groups
      (P>0.05). Detection rate was 100% for both Groups. The median number of sentinel 
      nodes in both Groups was one sentinel node. The mean number of detected sentinel 
      nodes during surgery was not statistically different between groups (1.28+/-0.7
      and 1.32+/-0.6 for Group I and II respectively). One false negative sentinel node
      case with positive axillary nodes after dissection was found in both groups. This
      amounts to 6.25% and 6.66% false negative rate for Group I and II patients
      respectively. During surgery mean count rate at the injection site was
      243123+/-22134 and 29430+/-2125 for Groups I and II, respectively. Mean count
      rate at the sentinel nodes was 4345+/-457 and 2375+/-356 for Groups I and II,
      respectively. Although the mean count rate at the injection site and the sentinel
      nodes were both higher in Group I of the study compared to Group II (P<0.0001 for
      both), the mean ratio of sentinel to injection site was statistically higher in
      Group II (P<0.0001). The 2 days protocol allows that the required
      lymphoscintigraphy imaging (including delayed views) can be performed before and 
      during operation without any time limits. Most studies have reported similar to
      ours detection or false negative rates for both protocols. Our study showed
      comparable mean number of harvested sentinel nodes by the two protocols which is 
      against the hypothesis of moving the tracer to other sentinel nodes by time.
      Others had similar results. The count rate of the sentinel nodes during surgery
      was statistically acceptable. Similar results have been reported by others too.
      Although we didn't evaluate radiation exposure in our study, this was acceptable 
      in other studies and Buscombe et al showed a maximum effective dose of
      2.6muSv/MBq for these patients and even assuming this highest value the patient
      exposure was very low compared to many other procedures. In conclusion, two days 
      protocol gives the sentinel node biopsy team considerable flexibility and
      lymphoscintigrpahy imaging can be completed before surgery. Finding of the
      axillary sentinel node during surgery is also being easier. False negative rates 
      as well as the detection rate for one day and two days protocols are comparable.
FAU - Ali, Jangijoo
AU  - Ali J
AD  - Surgical Oncology Research Center, Faculty of Medicine, Imam Reza Hospital,
      Mashhad University of Medical Sciences, Ebn Sina Street Mashhad, Iran.
      sadeghir@mums.ac.ir.
FAU - Alireza, Rezapanah
AU  - Alireza R
FAU - Mostafa, Mehrabibahar
AU  - Mostafa M
FAU - Naser, Forghani Mohammad
AU  - Naser FM
FAU - Bahram, Memar
AU  - Bahram M
FAU - Ramin, Sadeghi
AU  - Ramin S
LA  - eng
PT  - Letter
PL  - Greece
TA  - Hell J Nucl Med
JT  - Hellenic journal of nuclear medicine
JID - 101257471
RN  - 0 (Radiopharmaceuticals)
SB  - IM
MH  - Breast Neoplasms/diagnostic imaging
MH  - Humans
MH  - Lymph Nodes/diagnostic imaging
MH  - *Lymphatic Metastasis/diagnostic imaging
MH  - Radionuclide Imaging
MH  - *Radiopharmaceuticals/administration & dosage
MH  - Sentinel Lymph Node Biopsy
EDAT- 2011/11/17 06:00
MHDA- 2016/04/24 06:00
CRDT- 2011/11/17 06:00
PHST- 2011/11/17 06:00 [entrez]
PHST- 2011/11/17 06:00 [pubmed]
PHST- 2016/04/24 06:00 [medline]
PST - ppublish
SO  - Hell J Nucl Med. 2011 Sep-Dec;14(3):313-5.


PMID- 22086664
OWN - NLM
STAT- MEDLINE
DCOM- 20120330
LR  - 20151119
IS  - 1099-0798 (Electronic)
IS  - 0735-3936 (Linking)
VI  - 29
IP  - 6
DP  - 2011 Nov-Dec
TI  - Voluntary consent in correctional settings: do offenders feel coerced to
      participate in research?
PG  - 771-95
LID - 10.1002/bsl.1014 [doi]
AB  - A major ethical concern in research with criminal offenders is the potential for 
      abuse due to coercive influences that may adversely affect offenders' capacity to
      give voluntary consent to participate in research conducted in correctional
      settings. Despite this concern, to date there have been almost no systematic
      scientific investigations of the extent to which offenders themselves perceive
      that coercion occurs in these settings or that it is likely to influence their
      decisions about research participation. In a sample of over 600 ethnically
      diverse men and women recruited from various prisons and community corrections
      facilities in Texas and Florida, we used a vignette-based survey concerning a
      hypothetical research project to measure and compare offenders' global
      perceptions of coercive processes, as well as the differential salience and
      perceived coercive influence of specific factors (e.g., coercion by other
      inmates, inducements from staff). Somewhat surprisingly, across multiple outcome 
      measures our participants on average reported relatively little in the way of
      significant coercive influences on their capacity to make voluntary decisions
      concerning research participation. Implications and directions for future
      research on coercive influences in offender research are discussed.
CI  - 2011 John Wiley & Sons, Ltd.
FAU - Edens, John F
AU  - Edens JF
AD  - Department of Psychology, Texas A&M University, TAMU 4235, College Station, TX
      77843, USA. johnedens@tamu.edu
FAU - Epstein, Monica
AU  - Epstein M
FAU - Stiles, Paul G
AU  - Stiles PG
FAU - Poythress, Norman G Jr
AU  - Poythress NG Jr
LA  - eng
GR  - R01 MH081069/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Behav Sci Law
JT  - Behavioral sciences & the law
JID - 8404861
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Coercion
MH  - Female
MH  - Humans
MH  - *Informed Consent
MH  - Male
MH  - Middle Aged
MH  - Prisoners/*psychology
MH  - *Prisons
MH  - *Research
MH  - Surveys and Questionnaires
MH  - Texas
MH  - Young Adult
EDAT- 2011/11/17 06:00
MHDA- 2012/03/31 06:00
CRDT- 2011/11/17 06:00
PHST- 2011/11/17 06:00 [entrez]
PHST- 2011/11/17 06:00 [pubmed]
PHST- 2012/03/31 06:00 [medline]
AID - 10.1002/bsl.1014 [doi]
PST - ppublish
SO  - Behav Sci Law. 2011 Nov-Dec;29(6):771-95. doi: 10.1002/bsl.1014.


PMID- 22085735
OWN - NLM
STAT- MEDLINE
DCOM- 20120201
LR  - 20211021
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 12
DP  - 2011 Nov 16
TI  - Nurse managers' experience with ethical issues in six government hospitals in
      Malaysia: a cross-sectional study.
PG  - 23
LID - 10.1186/1472-6939-12-23 [doi]
AB  - BACKGROUND: Nurse managers have the burden of experiencing frequent ethical
      issues related to both their managerial and nursing care duties, according to
      previous international studies. However, no such study was published in Malaysia.
      The purpose of this study was to explore nurse managers' experience with ethical 
      issues in six government hospitals in Malaysia including learning about the way
      they dealt with the issues. METHODS: A cross-sectional study was conducted in
      August-September, 2010 involving 417 (69.2%) of total 603 nurse managers in the
      six Malaysian government hospitals. Data were collected using three-part
      self-administered questionnaire. Part I was regarding participants' demographics.
      Part II was about the frequency and areas of management where ethical issues were
      experienced, and scoring of the importance of 11 pre-identified ethical issues.
      Part III asked how they dealt with ethical issues in general; ways to deal with
      the 11 pre-identified ethical issues, and perceived stress level. Data were
      analyzed using descriptive statistics, cross-tabulations and Pearson's
      Chi-square. RESULTS: A total of 397 (95.2%) participants experienced ethical
      issues and 47.2% experienced them on weekly to daily basis. Experiencing ethical 
      issues were not associated with areas of practice. Top area of management where
      ethical issues were encountered was "staff management", but "patient care"
      related ethical issues were rated as most important. Majority would "discuss with
      other nurses" in dealing generally with the issues. For pre-identified ethical
      issues regarding "patient care", "discuss with doctors" was preferred. Only 18.1%
      referred issues to "ethics committees" and 53.0% to the code of ethics.
      CONCLUSIONS: Nurse managers, regardless of their areas of practice, frequently
      experienced ethical issues. For dealing with these, team-approach needs to be
      emphasized. Proper understanding of the code of ethics is needed to provide basis
      for reasoning.
FAU - Musa, Maizura binti
AU  - Musa Mb
AD  - Young Leaders' Program in Healthcare Administration, Nagoya University Graduate
      School of Medicine, Nagoya, Japan. maizuramusa@yahoo.com
FAU - Harun-Or-Rashid, M D
AU  - Harun-Or-Rashid MD
FAU - Sakamoto, Junichi
AU  - Sakamoto J
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20111116
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Adult
MH  - Attitude of Health Personnel
MH  - *Bioethical Issues
MH  - Cross-Sectional Studies
MH  - Female
MH  - *Hospitals, Public/ethics
MH  - Humans
MH  - Malaysia
MH  - Male
MH  - Middle Aged
MH  - Nurse Administrators/ethics/*statistics & numerical data
MH  - *Nurse's Role
MH  - Nursing Staff, Hospital/ethics/organization & administration
MH  - Physician-Nurse Relations
MH  - Surveys and Questionnaires
MH  - Workforce
PMC - PMC3228789
EDAT- 2011/11/17 06:00
MHDA- 2012/02/02 06:00
CRDT- 2011/11/17 06:00
PHST- 2011/06/09 00:00 [received]
PHST- 2011/11/16 00:00 [accepted]
PHST- 2011/11/17 06:00 [entrez]
PHST- 2011/11/17 06:00 [pubmed]
PHST- 2012/02/02 06:00 [medline]
AID - 1472-6939-12-23 [pii]
AID - 10.1186/1472-6939-12-23 [doi]
PST - epublish
SO  - BMC Med Ethics. 2011 Nov 16;12:23. doi: 10.1186/1472-6939-12-23.


PMID- 22085702
OWN - NLM
STAT- MEDLINE
DCOM- 20120201
LR  - 20220311
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 12
DP  - 2011 Nov 15
TI  - Ethics in practice: the state of the debate on promoting the social value of
      global health research in resource poor settings particularly Africa.
PG  - 22
LID - 10.1186/1472-6939-12-22 [doi]
AB  - BACKGROUND: Promoting the social value of global health research undertaken in
      resource poor settings has become a key concern in global research ethics. The
      consideration for benefit sharing, which concerns the elucidation of what if
      anything, is owed to participants, their communities and host nations that take
      part in such research, and the obligations of researchers involved, is one of the
      main strategies used for promoting social value of research. In the last decade
      however, there has been intense debate within academic bioethics literature
      seeking to define the benefits, the beneficiaries, and the scope of obligations
      for providing these benefits. Although this debate may be indicative of
      willingness at the international level to engage with the responsibilities of
      researchers involved in global health research, it remains unclear which forms of
      benefits or beneficiaries should be considered. International and local research 
      ethics guidelines are reviewed here to delineate the guidance they provide.
      METHODS: We reviewed documents selected from the international compilation of
      research ethics guidelines by the Office for Human Research Protections under the
      US Department of Health and Human Services. RESULTS: Access to interventions
      being researched, the provision of unavailable health care, capacity building for
      individuals and institutions, support to health care systems and access to
      medical and public health interventions proven effective, are the commonly
      recommended forms of benefits. The beneficiaries are volunteers, disease or
      illness affected communities and the population in general. Interestingly
      however, there is a divide between "global opinion" and the views of particular
      countries within resource poor settings as made explicit by differences in
      emphasis regarding the potential benefits and the beneficiaries. CONCLUSION:
      Although in theory benefit sharing is widely accepted as one of the means for
      promoting the social value of international collaborative health research, there 
      is less agreement amongst major guidelines on the specific responsibilities of
      researchers over what is ethical in promoting the social value of research. Lack 
      of consensus might have practical implications for efforts aimed at enhancing the
      social value of global health research undertaken in resource poor settings.
      Further developments in global research ethics require more reflection, paying
      attention to the practical realities of implementing the ethical principles in
      real world context.
CI  - (c) 2011 Lairumbi et al; licensee BioMed Central Ltd.
FAU - Lairumbi, Geoffrey M
AU  - Lairumbi GM
AD  - Child and Newborn Health Group, Kemri-Wellcome Trust Research Programme, PO Box
      43640, Nairobi, Kenya. lmbaabu@nairobi.kemri-wellcome.org
FAU - Michael, Parker
AU  - Michael P
FAU - Fitzpatrick, Raymond
AU  - Fitzpatrick R
FAU - English, Michael C
AU  - English MC
LA  - eng
GR  - 076827/Wellcome Trust/United Kingdom
GR  - 097170/Wellcome Trust/United Kingdom
GR  - 080594/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111115
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Africa
MH  - Bioethical Issues
MH  - Community-Based Participatory Research/*ethics/standards/trends
MH  - Ethics, Research
MH  - *Global Health
MH  - Humans
MH  - *Poverty
MH  - Public Health/*ethics
MH  - *Public Opinion
MH  - Research Personnel/ethics
MH  - *Social Values
PMC - PMC3225323
EDAT- 2011/11/17 06:00
MHDA- 2012/02/02 06:00
CRDT- 2011/11/17 06:00
PHST- 2010/12/20 00:00 [received]
PHST- 2011/11/15 00:00 [accepted]
PHST- 2011/11/17 06:00 [entrez]
PHST- 2011/11/17 06:00 [pubmed]
PHST- 2012/02/02 06:00 [medline]
AID - 1472-6939-12-22 [pii]
AID - 10.1186/1472-6939-12-22 [doi]
PST - epublish
SO  - BMC Med Ethics. 2011 Nov 15;12:22. doi: 10.1186/1472-6939-12-22.


PMID- 22084999
OWN - NLM
STAT- MEDLINE
DCOM- 20120319
LR  - 20111117
IS  - 1743-498X (Electronic)
IS  - 1743-4971 (Linking)
VI  - 8
IP  - 4
DP  - 2011 Dec
TI  - Death and dignity through fresh eyes.
PG  - 241-4
LID - 10.1111/j.1743-498X.2011.00491.x [doi]
AB  - BACKGROUND: Trinity College Dublin remains one of the Medical Schools that uses
      traditional dissection to teach anatomy, exposing students from the first week of
      entry to cadavers. This early exposure makes it imperative that issues
      surrounding death and donor remains are explored early on within the main
      structure of the curriculum. CONTEXT: The School of Medicine began a programme of
      Medical Humanities student-selected modules (SSMs) in 2010, and the opportunity
      to offer a module on medical ethics regarding death and dignity was taken.
      INNOVATION: A course was devised that touched only lightly on subjects such as
      palliative care and the concept of a good death. The course focused much more
      strongly on the reality of death as part of cultural and societal identity and
      placement. This was facilitated by field trips to settings where discussions
      regarding death, dying and dignity were commonplace and authentic experiences,
      rather than classroom discussions based on theoretical circumstances that may not
      yet have been experienced by the student. IMPLICATIONS: The module ran very well,
      with students feeling that they had had a chance to think critically about the
      role of death as an event with significance within society and culture, rather
      than purely in a medico-legal framework. Options to extend the module to the
      compulsory element of the course, to be built upon in later years looking at more
      technical aspects surrounding death, are being explored.
CI  - (c) Blackwell Publishing Ltd 2011.
FAU - Phillips, Matthew
AU  - Phillips M
AD  - School of Medicine, Trinity College, Dublin. mphilli@tcd.ie
FAU - Pilkington, Ruth
AU  - Pilkington R
FAU - Patterson, Aileen
AU  - Patterson A
FAU - Hennessy, Martina
AU  - Hennessy M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Teach
JT  - The clinical teacher
JID - 101227511
SB  - IM
MH  - *Death
MH  - Education, Medical/*organization & administration
MH  - Ethics, Medical
MH  - Humans
EDAT- 2011/11/17 06:00
MHDA- 2012/03/20 06:00
CRDT- 2011/11/17 06:00
PHST- 2011/11/17 06:00 [entrez]
PHST- 2011/11/17 06:00 [pubmed]
PHST- 2012/03/20 06:00 [medline]
AID - 10.1111/j.1743-498X.2011.00491.x [doi]
PST - ppublish
SO  - Clin Teach. 2011 Dec;8(4):241-4. doi: 10.1111/j.1743-498X.2011.00491.x.


PMID- 22084994
OWN - NLM
STAT- MEDLINE
DCOM- 20120319
LR  - 20111117
IS  - 1743-498X (Electronic)
IS  - 1743-4971 (Linking)
VI  - 8
IP  - 4
DP  - 2011 Dec
TI  - Hospital simulated patient programme: a guide.
PG  - 217-21
LID - 10.1111/j.1743-498X.2011.00479.x [doi]
AB  - CONTEXT: Many university courses employ simulated patients to work with students 
      in the development of communication skills. Our challenge was to build a
      sustainable programme that could be adapted for medical, nursing and allied
      health staff, and groups of students, on our hospital campus. INNOVATION: In
      recognition of the need to provide practice opportunities for junior medical
      staff to hone their capacity to communicate effectively with parents, we employed
      professional actors who are also qualified teachers. Junior doctors have multiple
      opportunities over their training time to work one-to-one with an actor-tutor in 
      the role of simulated parent. The simulated parents are skilled in helping the
      trainees reflect on the conversation, and the trainees are given a recording of
      their sessions for further reflection and feedback from a colleague. This model
      has been adapted to meet the 'topic' needs and scheduling requirements of other
      staff and hospital-based student groups. DISCUSSION: In adapting the original
      medical staff programme, we came to appreciate not only the logistical but also
      the ethical considerations inherent in a simulated parent/patient programme. Our 
      guide highlights the importance of safeguarding the educational integrity of the 
      design, maintaining the fidelity of the simulations and ensuring the safety of
      all involved.
CI  - (c) Blackwell Publishing Ltd 2011.
FAU - Barrett, Jenny
AU  - Barrett J
AD  - Department of Paediatrics, University of Melbourne, Melbourne, Victoria,
      Australia. jenny.barrett@rch.org.au
FAU - Hodgson, Jan
AU  - Hodgson J
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Teach
JT  - The clinical teacher
JID - 101227511
SB  - IM
MH  - *Communication
MH  - Education, Medical, Graduate/*methods/*organization & administration
MH  - Humans
MH  - *Medical Staff, Hospital
MH  - *Patient Simulation
EDAT- 2011/11/17 06:00
MHDA- 2012/03/20 06:00
CRDT- 2011/11/17 06:00
PHST- 2011/11/17 06:00 [entrez]
PHST- 2011/11/17 06:00 [pubmed]
PHST- 2012/03/20 06:00 [medline]
AID - 10.1111/j.1743-498X.2011.00479.x [doi]
PST - ppublish
SO  - Clin Teach. 2011 Dec;8(4):217-21. doi: 10.1111/j.1743-498X.2011.00479.x.


PMID- 22084861
OWN - NLM
STAT- MEDLINE
DCOM- 20120322
LR  - 20111117
IS  - 1539-6924 (Electronic)
IS  - 0272-4332 (Linking)
VI  - 31
IP  - 11
DP  - 2011 Nov
TI  - Nanotechnology risk perceptions and communication: emerging technologies,
      emerging challenges.
PG  - 1694-700
LID - 10.1111/j.1539-6924.2011.01738.x [doi]
AB  - Nanotechnology involves the fabrication, manipulation, and control of materials
      at the atomic level and may also bring novel uncertainties and risks. Potential
      parallels with other controversial technologies mean there is a need to develop a
      comprehensive understanding of processes of public perception of nanotechnology
      uncertainties, risks, and benefits, alongside related communication issues. Study
      of perceptions, at so early a stage in the development trajectory of a
      technology, is probably unique in the risk perception and communication field. As
      such it also brings new methodological and conceptual challenges. These include: 
      dealing with the inherent diversity of the nanotechnology field itself; the
      unfamiliar and intangible nature of the concept, with few analogies to anchor
      mental models or risk perceptions; and the ethical and value questions underlying
      many nanotechnology debates. Utilizing the lens of social amplification of risk, 
      and drawing upon the various contributions to this special issue of Risk Analysis
      on Nanotechnology Risk Perceptions and Communication, nanotechnology may at
      present be an attenuated hazard. The generic idea of "upstream public engagement"
      for emerging technologies such as nanotechnology is also discussed, alongside its
      importance for future work with emerging technologies in the risk communication
      field.
CI  - (c) 2011 Society for Risk Analysis.
FAU - Pidgeon, Nick
AU  - Pidgeon N
AD  - Understanding Risk Research Group, School of Psychology, Tower Building, Park
      Place, Cardiff CF10 3AT, Wales, UK. PidgeonN@cardiff.ac.uk
FAU - Harthorn, Barbara
AU  - Harthorn B
FAU - Satterfield, Terre
AU  - Satterfield T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Risk Anal
JT  - Risk analysis : an official publication of the Society for Risk Analysis
JID - 8109978
SB  - IM
MH  - Communication
MH  - Humans
MH  - *Nanotechnology
MH  - Perception
MH  - Research
MH  - *Risk Assessment
EDAT- 2011/11/17 06:00
MHDA- 2012/03/23 06:00
CRDT- 2011/11/17 06:00
PHST- 2011/11/17 06:00 [entrez]
PHST- 2011/11/17 06:00 [pubmed]
PHST- 2012/03/23 06:00 [medline]
AID - 10.1111/j.1539-6924.2011.01738.x [doi]
PST - ppublish
SO  - Risk Anal. 2011 Nov;31(11):1694-700. doi: 10.1111/j.1539-6924.2011.01738.x.


PMID- 22084854
OWN - NLM
STAT- MEDLINE
DCOM- 20120319
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 39
IP  - 4
DP  - 2011 Winter
TI  - Communitarianism and the ethics of communicable disease: some preliminary
      thoughts.
PG  - 678-89
LID - 10.1111/j.1748-720X.2011.00635.x [doi]
AB  - Communicable diseases, especially those that are highly contagious, are on the
      rise and each of us, no matter who we are or where we live, is equally at risk of
      transmitting contagious diseases to others as we are of contracting such diseases
      from others. Because contagious diseases are as readily passed state-to-state as 
      person-to-person, we all have a stake in every country's ability to enact
      effective infectious disease control policies, while policies grounded in shared 
      values are more likely to gain widespread acceptance and thereby prove most
      effective. This paper suggests that principlism proved invaluable as an ethical
      framework for resolving hard medical cases and setting health care policy because
      it nicely "fits" dilemmas that arise in the context of the special relationship
      between doctors and patients or within family units. It then argues that
      communitarianism provides the better foundation for crafting infectious diseases 
      control policies because contagious diseases, which often pass between perfect
      strangers, raise questions about the moral obligations we owe to (or are entitled
      to demand of) people with whom we share no "special" relationship. Accordingly, a
      socially embedded framework such as communitarianism may be a better fit for the 
      more socially embedded ethical dilemmas of communicable diseases.
CI  - (c) 2011 American Society of Law, Medicine & Ethics, Inc.
FAU - Cheyette, Cara M
AU  - Cheyette CM
AD  - Boston University Metropolitan College, MA, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - *Bioethical Issues
MH  - *Communicable Disease Control
MH  - Humans
MH  - *Principle-Based Ethics
MH  - *Social Responsibility
EDAT- 2011/11/17 06:00
MHDA- 2012/03/20 06:00
CRDT- 2011/11/17 06:00
PHST- 2011/11/17 06:00 [entrez]
PHST- 2011/11/17 06:00 [pubmed]
PHST- 2012/03/20 06:00 [medline]
AID - 10.1111/j.1748-720X.2011.00635.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2011 Winter;39(4):678-89. doi:
      10.1111/j.1748-720X.2011.00635.x.


PMID- 22084852
OWN - NLM
STAT- MEDLINE
DCOM- 20120319
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 39
IP  - 4
DP  - 2011 Winter
TI  - Reforming pharmaceutical industry-physician financial relationships: lessons from
      the United States, France, and Japan.
PG  - 662-70
LID - 10.1111/j.1748-720X.2011.00633.x [doi]
AB  - This article compares the means that the United States, France, and Japan use to 
      oversee pharmaceutical industry-physician financial relationships. These
      countries rely on professional and/or industry ethical codes, anti-kickback laws,
      and fair trade practice laws. They restrict kickbacks the most strictly, allow
      wide latitude on gifts, and generally permit drug firms to fund professional
      activities and associations. Consequently, to avoid legal liability, drug firms
      often replace kickbacks with gifts and grants. The paper concludes by proposing
      reforms that address problems that persist when firms replace kickbacks with
      gifts and grants based on the experience of the three countries.
CI  - (c) 2011 American Society of Law, Medicine & Ethics, Inc.
FAU - Rodwin, Marc A
AU  - Rodwin MA
AD  - Harvard University, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Codes of Ethics
MH  - *Conflict of Interest
MH  - Drug Industry/*ethics
MH  - Education, Medical, Continuing/economics
MH  - France
MH  - Fraud/ethics/legislation & jurisprudence
MH  - Gift Giving/ethics
MH  - Humans
MH  - Interprofessional Relations/*ethics
MH  - Japan
MH  - Physicians/*ethics
MH  - Practice Patterns, Physicians'
MH  - Training Support/legislation & jurisprudence
MH  - United States
EDAT- 2011/11/17 06:00
MHDA- 2012/03/20 06:00
CRDT- 2011/11/17 06:00
PHST- 2011/11/17 06:00 [entrez]
PHST- 2011/11/17 06:00 [pubmed]
PHST- 2012/03/20 06:00 [medline]
AID - 10.1111/j.1748-720X.2011.00633.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2011 Winter;39(4):662-70. doi:
      10.1111/j.1748-720X.2011.00633.x.


PMID- 22084851
OWN - NLM
STAT- MEDLINE
DCOM- 20120319
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 39
IP  - 4
DP  - 2011 Winter
TI  - An ethics expertise for clinical ethics consultation.
PG  - 649-61
LID - 10.1111/j.1748-720X.2011.00632.x [doi]
AB  - The legitimacy of clinical ethics consultation is often implied to rest on the
      legitimacy of moral expertise. In turn, moral expertise seems subject to many
      serious critiques, the success of which implies that clinical ethics consultation
      is illegitimate. I explore a number of these critiques, and forward "ethics
      expertise," as distinct from "moral expertise," as a way of avoiding these
      critiques. I argue that "ethics expertise" succeeds in avoiding most of the
      critiques, captures what clinical ethics consultants might justifiably do, and
      expresses a subject matter which can be taught and assessed.
CI  - (c) 2011 American Society of Law, Medicine & Ethics, Inc.
FAU - Rasmussen, Lisa M
AU  - Rasmussen LM
AD  - Department of Philosophy, UNC Charlotte, NC, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - *Bioethical Issues
MH  - *Ethicists/standards
MH  - Humans
MH  - United States
EDAT- 2011/11/17 06:00
MHDA- 2012/03/20 06:00
CRDT- 2011/11/17 06:00
PHST- 2011/11/17 06:00 [entrez]
PHST- 2011/11/17 06:00 [pubmed]
PHST- 2012/03/20 06:00 [medline]
AID - 10.1111/j.1748-720X.2011.00632.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2011 Winter;39(4):649-61. doi:
      10.1111/j.1748-720X.2011.00632.x.


PMID- 22084849
OWN - NLM
STAT- MEDLINE
DCOM- 20120319
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 39
IP  - 4
DP  - 2011 Winter
TI  - The needle in the haystack: international consortia and the return of individual 
      research results.
PG  - 631-9
LID - 10.1111/j.1748-720X.2011.00630.x [doi]
AB  - Returning individual results to participants in research studies is gaining
      acceptance and policy guidance is now available for investigators to develop a
      plan for returning results at the local level. However, returning results
      discovered through the work of an international scientific research consortium
      presents additional ethical and procedural difficulties. No general guidance is
      available for international consortia that wish to consider this issue, but there
      are examples of internal policies that are being used by consortia such as the
      International Cancer Genome Consortium (ICGC) and the Type 1 Diabetes Genetics
      Consortium (T1DGC). This paper presents the policy stance these studies have
      adopted regarding returning individual research results and their reasons behind 
      it, and gives specific examples from their policy documents and project consent
      materials. Finally, it suggests an oversight mechanism these and other
      international consortia can use to ensure that this important issue is addressed 
      appropriately.
CI  - (c) 2011 American Society of Law, Medicine & Ethics, Inc.
FAU - Wallace, Susan E
AU  - Wallace SE
AD  - Population and Public Health Sciences, University of Leicester, Leicester, UK.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Consent Forms
MH  - Disclosure/*ethics
MH  - *Genetic Research
MH  - *Genetic Testing
MH  - Humans
MH  - *Internationality
MH  - Policy
MH  - *Research Subjects
EDAT- 2011/11/17 06:00
MHDA- 2012/03/20 06:00
CRDT- 2011/11/17 06:00
PHST- 2011/11/17 06:00 [entrez]
PHST- 2011/11/17 06:00 [pubmed]
PHST- 2012/03/20 06:00 [medline]
AID - 10.1111/j.1748-720X.2011.00630.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2011 Winter;39(4):631-9. doi: 10.1111/j.1748-720X.2011.00630.x.


PMID- 22084848
OWN - NLM
STAT- MEDLINE
DCOM- 20120319
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 39
IP  - 4
DP  - 2011 Winter
TI  - The return of results of deceased research participants.
PG  - 621-30
LID - 10.1111/j.1748-720X.2011.00629.x [doi]
AB  - The death of a research participant raises numerous ethical and legal issues
      regarding the return of research results to related family members. This question
      is particularly acute in the context of genetic research since the research
      results from an individual may be relevant to each of the biological relatives.
      This paper first investigates the ethical and legal frameworks governing the
      return of a deceased participant's individual research results to his or her
      related family members. Then, it weighs the rights and interests of both the
      deceased individual and related family members in an attempt to identify key
      ethical considerations underlying the return of such results. This analysis of
      international guidelines and national laws and regulations reveals that though
      the legal framework regarding privacy and confidentiality of clinical and
      research information is well established (albeit not homogenous), guidelines are 
      generally absent in the post-mortem context. Nevertheless, a brief analysis of
      this issue through two ethical perspectives (principlism and consequentialism)
      allows us to identify six key elements to be taken into consideration when
      returning a deceased participant's research results.
CI  - (c) 2011 American Society of Law, Medicine & Ethics, Inc.
FAU - Tasse, Anne Marie
AU  - Tasse AM
AD  - Centre for Genomics and Policy at McGill University, Canada.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - *Death
MH  - Disclosure/*ethics/legislation & jurisprudence
MH  - *Family
MH  - *Genetic Research
MH  - *Genetic Testing
MH  - Guidelines as Topic
MH  - Humans
MH  - Internationality
MH  - *Research Subjects
EDAT- 2011/11/17 06:00
MHDA- 2012/03/20 06:00
CRDT- 2011/11/17 06:00
PHST- 2011/11/17 06:00 [entrez]
PHST- 2011/11/17 06:00 [pubmed]
PHST- 2012/03/20 06:00 [medline]
AID - 10.1111/j.1748-720X.2011.00629.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2011 Winter;39(4):621-30. doi:
      10.1111/j.1748-720X.2011.00629.x.


PMID- 22084845
OWN - NLM
STAT- MEDLINE
DCOM- 20120319
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 39
IP  - 4
DP  - 2011 Winter
TI  - Pediatric research and the return of individual research results.
PG  - 593-604
LID - 10.1111/j.1748-720X.2011.00626.x [doi]
AB  - The return of individual research results to participants raises many
      socio-ethical issues and is even more challenging when the participant is a
      child. The objective of this article is to present an overview of the few ethical
      guidelines and relevant literature addressing the return of individual results in
      pediatric research. By reviewing policies and the literature, we present some
      overarching considerations and delineate contextual issues in order to propose a 
      framework.
CI  - (c) 2011 American Society of Law, Medicine & Ethics, Inc.
FAU - Avard, Denise
AU  - Avard D
AD  - Centre of Genomics and Policy at McGill University, Canada.
FAU - Senecal, Karine
AU  - Senecal K
FAU - Madadi, Parvaz
AU  - Madadi P
FAU - Sinnett, Daniel
AU  - Sinnett D
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - *Biological Specimen Banks
MH  - Child
MH  - *Child Advocacy
MH  - Disclosure/*ethics
MH  - Genetic Research/*ethics
MH  - Humans
MH  - Informed Consent By Minors
MH  - Personal Autonomy
EDAT- 2011/11/17 06:00
MHDA- 2012/03/20 06:00
CRDT- 2011/11/17 06:00
PHST- 2011/11/17 06:00 [entrez]
PHST- 2011/11/17 06:00 [pubmed]
PHST- 2012/03/20 06:00 [medline]
AID - 10.1111/j.1748-720X.2011.00626.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2011 Winter;39(4):593-604. doi:
      10.1111/j.1748-720X.2011.00626.x.


PMID- 22084844
OWN - NLM
STAT- MEDLINE
DCOM- 20120319
LR  - 20220410
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 39
IP  - 4
DP  - 2011 Winter
TI  - Return of research results: general principles and international perspectives.
PG  - 583-92
LID - 10.1111/j.1748-720X.2011.00625.x [doi]
AB  - Five years ago, an article co-written by two of us (Joly and Simard) presented an
      emerging trend to disclose certain individual genetic results to research
      participants. Since then, both technologies and research practices have evolved
      significantly. Given this rapid evolution, our goal is to provide updated and
      thorough guidance on this issue. Our paper begins by identifying the ethical
      principles that support the return of results: justice, beneficence, and respect 
      for persons. Then, it presents the results of an analysis of international norms 
      on the return of results, covering both general and individual research results. 
      It reveals existing divergence and consensus on these topics within the
      international community. With the goal of promoting greater harmonization, we
      conclude by proposing a flexible framework for the return of individual research 
      results.
CI  - (c) 2011 American Society of Law, Medicine & Ethics, Inc.
FAU - Levesque, Emmanuelle
AU  - Levesque E
AD  - Centre of Genomics and Policy of McGill University, Canada.
FAU - Joly, Yann
AU  - Joly Y
FAU - Simard, Jacques
AU  - Simard J
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - *Bioethical Issues
MH  - *Biological Specimen Banks/ethics
MH  - *Disclosure/ethics
MH  - Genetic Research/*ethics
MH  - Guidelines as Topic
MH  - Humans
MH  - *Information Dissemination/ethics
MH  - *Internationality
MH  - Research Subjects
EDAT- 2011/11/17 06:00
MHDA- 2012/03/20 06:00
CRDT- 2011/11/17 06:00
PHST- 2011/11/17 06:00 [entrez]
PHST- 2011/11/17 06:00 [pubmed]
PHST- 2012/03/20 06:00 [medline]
AID - 10.1111/j.1748-720X.2011.00625.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2011 Winter;39(4):583-92. doi:
      10.1111/j.1748-720X.2011.00625.x.


PMID- 22084843
OWN - NLM
STAT- MEDLINE
DCOM- 20120319
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 39
IP  - 4
DP  - 2011 Winter
TI  - Return of results: towards a lexicon?
PG  - 577-82
LID - 10.1111/j.1748-720X.2011.00624.x [doi]
AB  - Currently, the return of results in the domain of biobanking constitutes an
      ethical and legal quagmire, whether it involves population or specific clinical
      research studies. In light of the fact that population biobanks are often not
      seen as distinct from those biobanks created for disease research, as well as the
      uncertainty as to what "return of results" means concretely, this lexicon
      attempts to demystify the terminology. The terms - results, return, clinical
      significance, and utility - are discussed. Through an analysis of international
      and national normative guidance on this issue, the authors propose a concordance 
      of meaning and a simplified lexicon.
CI  - (c) 2011 American Society of Law, Medicine & Ethics, Inc.
FAU - Knoppers, Bartha Maria
AU  - Knoppers BM
AD  - Department of Human Genetics, Faculty of Medicine at McGill University, Montreal,
      Canada.
FAU - Dam, Amy
AU  - Dam A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - *Biological Specimen Banks
MH  - Disclosure/*ethics
MH  - *Genetic Research
MH  - Guidelines as Topic
MH  - Humans
MH  - Information Dissemination/*ethics
MH  - *Terminology as Topic
EDAT- 2011/11/17 06:00
MHDA- 2012/03/20 06:00
CRDT- 2011/11/17 06:00
PHST- 2011/11/17 06:00 [entrez]
PHST- 2011/11/17 06:00 [pubmed]
PHST- 2012/03/20 06:00 [medline]
AID - 10.1111/j.1748-720X.2011.00624.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2011 Winter;39(4):577-82. doi:
      10.1111/j.1748-720X.2011.00624.x.


PMID- 22084483
OWN - NLM
STAT- MEDLINE
DCOM- 20120403
LR  - 20111115
IS  - 1552-549X (Electronic)
IS  - 1074-8407 (Linking)
VI  - 17
IP  - 4
DP  - 2011 Nov
TI  - Misconceptions about missed conceptions: the meanings of emergency contraceptive 
      pills use among young adult couples.
PG  - 463-84
LID - 10.1177/1074840711424158 [doi]
AB  - Emergency contraceptive pills (ECP) are a safe and efficacious backup method of
      birth control. Despite widespread availability, ECP is underutilized by young
      women. While partner level of involvement has been shown to influence
      contraceptive behavior, there is a dearth of knowledge regarding any possible
      association between partner influence and ECP use. To better understand the
      reasons for the seemingly underuse of ECP, a grounded theory study was conducted 
      to elucidate the relationship of couple dynamics and knowledge of, attitudes
      toward, and decision making regarding the use of ECP in coupled young adults.
      Consistent with contemporary constructivist grounded theory methods, several
      categories were identified including the meanings associated with ECP use. This
      article presents an elaboration of this particular finding. The meanings that
      participants ascribed to ECP use represented a continuum of value attributes
      regarding ethics, safety, efficacy, and responsibility.
FAU - Beaulieu, Richard
AU  - Beaulieu R
AD  - Children's Aid Society, Bronx, NY 10460, USA. rbeaulieu@childrensaidsociety.org
FAU - Kools, Susan
AU  - Kools S
FAU - Kennedy, Holly Powell
AU  - Kennedy HP
FAU - Humphreys, Janice
AU  - Humphreys J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Fam Nurs
JT  - Journal of family nursing
JID - 9503761
RN  - 0 (Contraceptives, Postcoital)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Contraception Behavior
MH  - *Contraceptives, Postcoital
MH  - Decision Making
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Male
MH  - Morals
EDAT- 2011/11/16 06:00
MHDA- 2012/04/04 06:00
CRDT- 2011/11/16 06:00
PHST- 2011/11/16 06:00 [entrez]
PHST- 2011/11/16 06:00 [pubmed]
PHST- 2012/04/04 06:00 [medline]
AID - 17/4/463 [pii]
AID - 10.1177/1074840711424158 [doi]
PST - ppublish
SO  - J Fam Nurs. 2011 Nov;17(4):463-84. doi: 10.1177/1074840711424158.


PMID- 22084324
OWN - NLM
STAT- MEDLINE
DCOM- 20120124
LR  - 20111202
IS  - 1098-4275 (Electronic)
IS  - 0031-4005 (Linking)
VI  - 128
IP  - 6
DP  - 2011 Dec
TI  - Contemporary ethical issues in human milk-banking in the United States.
PG  - 1186-91
LID - 10.1542/peds.2010-2040 [doi]
AB  - Donor human milk has been used in the United States for >90 years, but recent
      advances in human milk science and laboratory techniques have led to increasing
      use of this resource. Pediatricians began using donor human milk in the 1900s in 
      response to anecdotal observation that premature infants had better health
      outcomes when receiving their own mothers' milk. Since then, a formalized human
      milk-banking system developed in the mid-1980s and distributed >1 million ounces 
      of pasteurized donor human milk in 2008. Despite growth in the use of pasteurized
      donor human milk, there is little discussion in the medical literature regarding 
      the ethical considerations of collection and use of this resource. Key ethical
      considerations include issues surrounding medical decision-making and informed
      consent, increasing the limited supply of human milk, how ethically to allocate
      this scarce resource, and concerns linked to the marketing of a human milk.
FAU - Miracle, Donna J
AU  - Miracle DJ
AD  - Rush University College of Nursing, Chicago, IL, USA. donnajomiracle@gmail.com
FAU - Szucs, Kinga A
AU  - Szucs KA
FAU - Torke, Alexia M
AU  - Torke AM
FAU - Helft, Paul R
AU  - Helft PR
LA  - eng
PT  - Journal Article
DEP - 20111114
PL  - United States
TA  - Pediatrics
JT  - Pediatrics
JID - 0376422
SB  - IM
MH  - Bioethical Issues
MH  - Humans
MH  - Informed Consent
MH  - Milk Banks/*ethics/supply & distribution
MH  - Milk, Human
MH  - United States
EDAT- 2011/11/16 06:00
MHDA- 2012/01/25 06:00
CRDT- 2011/11/16 06:00
PHST- 2011/11/16 06:00 [entrez]
PHST- 2011/11/16 06:00 [pubmed]
PHST- 2012/01/25 06:00 [medline]
AID - peds.2010-2040 [pii]
AID - 10.1542/peds.2010-2040 [doi]
PST - ppublish
SO  - Pediatrics. 2011 Dec;128(6):1186-91. doi: 10.1542/peds.2010-2040. Epub 2011 Nov
      14.


PMID- 22084211
OWN - NLM
STAT- MEDLINE
DCOM- 20120228
LR  - 20220409
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 262
IP  - 1
DP  - 2012 Jan
TI  - Acute lower intestinal bleeding: feasibility and diagnostic performance of CT
      angiography.
PG  - 109-16
LID - 10.1148/radiol.11110326 [doi]
AB  - PURPOSE: To assess the diagnostic performance of computed tomographic (CT)
      angiography as the initial diagnostic examination for patients presenting to the 
      emergency room with acute lower intestinal bleeding. MATERIALS AND METHODS: The
      study was reviewed and approved by the ethics committee, and written informed
      consent was obtained from each patient or their closest relative when the
      clinical condition precluded consent by the patient. This prospective study
      comprised 47 patients (27 men, 20 women; mean age, 68 years) with acute lower
      gastrointestinal tract bleeding who were referred to undergo emergency
      colonoscopy for evaluation. CT angiography was performed in all patients shortly 
      after arrival to the emergency room. Findings identified at CT angiography
      included active extravasation (ongoing hemorrhage) or hyperattenuating
      intraluminal contents on noncontrast material-enhanced images (recent
      hemorrhage). Presence and location of bleeding and likely cause of hemorrhage
      were determined and compared with the standard of reference (angiography,
      colonoscopy, or surgical findings). Data collected were analyzed with a
      statistical software package. Sensitivity, specificity, and positive and negative
      predictive values of CT angiography in depicting ongoing or recent hemorrhage
      were calculated and compared with those of standard of reference. RESULTS: CT
      angiography demonstrated active bleeding in 14 patients and intraluminal
      hyperattenuating material in six patients. The sensitivity, specificity, positive
      predictive value, and negative predictive value of CT angiography in depicting
      active or recent bleeding were 100% (19 of 19), 96% (27 of 28), 95% (19 of 20),
      and 100% (27 of 27), respectively. Findings of CT angiography and the standard of
      reference were concordant for determining definite or potential cause of bleeding
      in 44 of 47 patients (93% accuracy). CONCLUSION: CT angiography performed in the 
      emergency setting in patients with acute lower intestinal bleeding is feasible
      and correctly depicts the presence and location of active or recent hemorrhage,
      as well as the potential cause, in the majority of patients.
CI  - (c) RSNA, 2011.
FAU - Marti, Milagros
AU  - Marti M
AD  - Department of Radiology, La Paz University Hospital, Paseo de la Castellana 261, 
      28046 Madrid, Spain. mmarti.hulp@salud.madrid.org
FAU - Artigas, Jose M
AU  - Artigas JM
FAU - Garzon, Gonzalo
AU  - Garzon G
FAU - Alvarez-Sala, Rodolfo
AU  - Alvarez-Sala R
FAU - Soto, Jorge A
AU  - Soto JA
LA  - eng
PT  - Journal Article
DEP - 20111114
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - 0 (Triiodobenzoic Acids)
RN  - N3RIB7X24K (ioversol)
SB  - IM
CIN - Radiologe. 2012 May;52(5):421-2. PMID: 22552448
MH  - Acute Disease
MH  - Aged
MH  - Angiography/*methods
MH  - Colonoscopy
MH  - Contrast Media
MH  - Extravasation of Diagnostic and Therapeutic Materials
MH  - Female
MH  - Gastrointestinal Hemorrhage/*diagnostic imaging
MH  - Humans
MH  - Lower Gastrointestinal Tract/*diagnostic imaging
MH  - Male
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Radiographic Image Interpretation, Computer-Assisted
MH  - Sensitivity and Specificity
MH  - Tomography, X-Ray Computed/*methods
MH  - Triiodobenzoic Acids
EDAT- 2011/11/16 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/11/16 06:00
PHST- 2011/11/16 06:00 [entrez]
PHST- 2011/11/16 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - radiol.11110326 [pii]
AID - 10.1148/radiol.11110326 [doi]
PST - ppublish
SO  - Radiology. 2012 Jan;262(1):109-16. doi: 10.1148/radiol.11110326. Epub 2011 Nov
      14.


PMID- 22084203
OWN - NLM
STAT- MEDLINE
DCOM- 20120228
LR  - 20151119
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 262
IP  - 1
DP  - 2012 Jan
TI  - Prognostic implications of dipyridamole cardiac MR imaging: a prospective
      multicenter registry.
PG  - 91-100
LID - 10.1148/radiol.11110134 [doi]
AB  - PURPOSE: To evaluate dipyridamole cardiac magnetic resonance (MR) imaging in the 
      prediction of major events (MEs) in patients with ischemic chest pain in a large 
      multicenter registry. MATERIALS AND METHODS: Institutional ethics committee
      approval and written informed consent were obtained. A total of 1722 patients who
      were undergoing cardiac MR imaging for chest pain were included. Wall motion
      abnormalities (WMAs) at rest, hyperemia perfusion defect (PD), late gadolinium
      enhancement (LGE), and inducible WMA were analyzed (abnormal if more than one
      abnormal segment was seen) with the 17-segment model. A cardiac MR categorization
      was created: category 1, no PD, LGE, or inducible WMA; category 2, PD without LGE
      and inducible WMA; category 3, LGE without inducible WMA; and category 4,
      inducible WMA. The association with ME was analyzed by using Cox proportional
      hazard regression multivariate models. RESULTS: During a median follow-up period 
      of 308 days, 61 MEs (4%) occurred (36 cardiac deaths, 25 nonfatal myocardial
      infarctions). MEs were associated with a greater extent of WMA, PD, LGE, and
      inducible WMA (P </= .001 for all analyses). In multivariable analyses, PD (P =
      .002) and inducible WMA (P = .0001) were the only cardiac MR predictors. ME rate 
      in categories 1, 2, 3, and 4 was 2% (14 of 901 patients), 3% (six of 219
      patients), 4% (15 of 409 patients), and 14% (26 of 193 patients), respectively
      (category 4 vs category 1, adjusted P < .001). Cardiac MR-directed
      revascularization was performed in 242 patients (14%) and reduced the risk of ME 
      in only category 4 (7% [six of 92 patients] vs 26% [26 of 101 patients], P =
      .0004). CONCLUSION: Dipyridamole cardiac MR imaging can be used to predict MEs in
      patients with ischemic chest pain. Patients with inducible WMA are at the highest
      risk for MEs and benefit the most from revascularization.
CI  - (c) RSNA, 2011.
FAU - Bodi, Vicente
AU  - Bodi V
AD  - Department of Cardiology, Hospital Clinico Universitario, INCLIVA, Universidad de
      Valencia, Blasco Ibanez 17, Valencia 46010, Spain. vicentbodi@hotmail.com
FAU - Husser, Oliver
AU  - Husser O
FAU - Sanchis, Juan
AU  - Sanchis J
FAU - Nunez, Julio
AU  - Nunez J
FAU - Monmeneu, Jose V
AU  - Monmeneu JV
FAU - Lopez-Lereu, Maria P
AU  - Lopez-Lereu MP
FAU - Bosch, Maria J
AU  - Bosch MJ
FAU - Rumiz, Eva
AU  - Rumiz E
FAU - Minana, Gema
AU  - Minana G
FAU - Garcia, Carlos
AU  - Garcia C
FAU - Diago, Jose L
AU  - Diago JL
FAU - Chaustre, Fabian
AU  - Chaustre F
FAU - Moratal, David
AU  - Moratal D
FAU - Gomez, Cristina
AU  - Gomez C
FAU - Aguilar, Jose
AU  - Aguilar J
FAU - Chorro, Francisco J
AU  - Chorro FJ
FAU - Llacer, Angel
AU  - Llacer A
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20111114
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - 0 (Vasodilator Agents)
RN  - 64ALC7F90C (Dipyridamole)
SB  - IM
MH  - Aged
MH  - Artifacts
MH  - Case-Control Studies
MH  - Chest Pain/*diagnosis/mortality/therapy
MH  - Chi-Square Distribution
MH  - Contrast Media
MH  - *Dipyridamole
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/diagnosis/mortality/therapy
MH  - Myocardial Ischemia/*diagnosis/mortality/therapy
MH  - Myocardial Revascularization
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Prospective Studies
MH  - Registries
MH  - Reproducibility of Results
MH  - Statistics, Nonparametric
MH  - *Vasodilator Agents
EDAT- 2011/11/16 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/11/16 06:00
PHST- 2011/11/16 06:00 [entrez]
PHST- 2011/11/16 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - radiol.11110134 [pii]
AID - 10.1148/radiol.11110134 [doi]
PST - ppublish
SO  - Radiology. 2012 Jan;262(1):91-100. doi: 10.1148/radiol.11110134. Epub 2011 Nov
      14.


PMID- 22084032
OWN - NLM
STAT- MEDLINE
DCOM- 20121019
LR  - 20161125
IS  - 2042-7670 (Electronic)
IS  - 0042-4900 (Linking)
VI  - 170
IP  - 1
DP  - 2012 Jan 7
TI  - Survey of the frequency and perceived stressfulness of ethical dilemmas
      encountered in UK veterinary practice.
PG  - 19
LID - 10.1136/vr.100262 [doi]
AB  - The scale of the ethical challenges faced by veterinary surgeons and their
      perceived stressful consequences were investigated via a short questionnaire,
      completed by 58 practising veterinary surgeons. Respondents were asked to report 
      how frequently they faced ethical dilemmas, and to rate on a simple numerical
      scale (zero to 10) how stressful they found three common scenarios. Fifty seven
      per cent of respondents reported that they faced one to two dilemmas per week,
      while 34 per cent stated they typically faced three to five dilemmas per week.
      The three scenarios provided were all rated as highly stressful with 'client
      wishing to continue treatment despite poor animal welfare' rated as the most
      stressful (median 9). The female veterinary surgeons gave two of the scenarios
      significantly higher stress ratings than the male veterinary surgeons. Stress
      ratings were not influenced by number of years in practice (which ranged from one
      to more than 25 years). The results show that veterinary surgeons regularly face 
      ethical dilemmas and that they find these stressful. This has implications for
      the wellbeing of veterinary surgeons and supports the case for increased
      provision of training and support, especially for those who entered the
      profession before undergraduate ethics teaching was widely available.
FAU - Batchelor, C E M
AU  - Batchelor CE
AD  - Institute for Biodiversity, Animal Health and Comparative Medicine, College of
      Medical, Veterinary & Life Sciences, University of Glasgow, Bearsden Road,
      Glasgow G61 1QH, UK.
FAU - McKeegan, D E F
AU  - McKeegan DE
LA  - eng
PT  - Journal Article
DEP - 20111114
PL  - England
TA  - Vet Rec
JT  - The Veterinary record
JID - 0031164
SB  - IM
EIN - Vet Rec. 2012 Jan 7;170(1):19
MH  - Animal Welfare/ethics
MH  - Euthanasia, Animal/ethics
MH  - Female
MH  - Humans
MH  - Male
MH  - Psychometrics
MH  - *Stress, Psychological
MH  - Surveys and Questionnaires
MH  - United Kingdom
MH  - Veterinarians/ethics/*psychology
MH  - Veterinary Medicine/*ethics
EDAT- 2011/11/16 06:00
MHDA- 2012/10/20 06:00
CRDT- 2011/11/16 06:00
PHST- 2011/11/16 06:00 [entrez]
PHST- 2011/11/16 06:00 [pubmed]
PHST- 2012/10/20 06:00 [medline]
AID - vr.100262 [pii]
AID - 10.1136/vr.100262 [doi]
PST - ppublish
SO  - Vet Rec. 2012 Jan 7;170(1):19. doi: 10.1136/vr.100262. Epub 2011 Nov 14.


PMID- 22083572
OWN - NLM
STAT- MEDLINE
DCOM- 20111227
LR  - 20210503
IS  - 1538-3679 (Electronic)
IS  - 0003-9926 (Linking)
VI  - 171
IP  - 20
DP  - 2011 Nov 14
TI  - Growth in dementia-associated hospitalizations among the oldest old in the United
      States: implications for ethical health services planning.
PG  - 1850-1
LID - 10.1001/archinternmed.2011.503 [doi]
FAU - Zilberberg, Marya D
AU  - Zilberberg MD
FAU - Tjia, Jennifer
AU  - Tjia J
LA  - eng
PT  - Letter
PL  - United States
TA  - Arch Intern Med
JT  - Archives of internal medicine
JID - 0372440
SB  - IM
CIN - Arch Intern Med. 2011 Nov 14;171(20):1852-3. PMID: 22083574
MH  - Aged, 80 and over
MH  - *Dementia/economics/epidemiology/therapy
MH  - Ethical Analysis
MH  - Female
MH  - Health Care Costs/*ethics
MH  - Health Services Misuse/*economics
MH  - Health Transition
MH  - Hospitalization/economics
MH  - Humans
MH  - Male
EDAT- 2011/11/16 06:00
MHDA- 2011/12/28 06:00
CRDT- 2011/11/16 06:00
PHST- 2011/11/16 06:00 [entrez]
PHST- 2011/11/16 06:00 [pubmed]
PHST- 2011/12/28 06:00 [medline]
AID - 171/20/1850 [pii]
AID - 10.1001/archinternmed.2011.503 [doi]
PST - ppublish
SO  - Arch Intern Med. 2011 Nov 14;171(20):1850-1. doi: 10.1001/archinternmed.2011.503.


PMID- 22083341
OWN - NLM
STAT- MEDLINE
DCOM- 20131126
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 1
DP  - 2013 Mar
TI  - Measuring sensitivity to conflicts of interest: a preliminary test of method.
PG  - 43-62
LID - 10.1007/s11948-011-9319-6 [doi]
AB  - This study presents and develops test methods for assessing sensitivity to
      conflict of interest (COIsen). We are aware of no study assessing COIsen, but
      note that some popular methods for assessing ethical sensitivity and related
      constructs (which include COIsen) are flawed in that their presentation of
      stimulus material to subjects actually guides subjects to attend to ethical (or
      related) issues. The method tested here was designed to avoid this flaw. Using
      adaptations of two existing cases, a quota sample of 12 students was interviewed.
      Our method used funnel-sequenced, open-ended interviews that were audiotaped and 
      transcribed, then subjected to a form of cognitive mapping. These maps revealed
      the presence of "indicators" of COIsen. We found that COIsen can be measured and 
      that the global COIsen score generated by our method is able to reveal much
      variation across subjects, making it a worthwhile candidate for further
      consideration.
FAU - Lind, Rebecca Ann
AU  - Lind RA
AD  - Department of Communication, University of Illinois, Chicago, IL, USA.
      rebecca@uic.edu
FAU - Swenson-Lepper, Tammy
AU  - Swenson-Lepper T
LA  - eng
PT  - Journal Article
DEP - 20111115
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Awareness
MH  - *Conflict of Interest
MH  - *Ethics, Research
MH  - Humans
MH  - Interviews as Topic
MH  - *Perception
EDAT- 2011/11/16 06:00
MHDA- 2013/12/16 06:00
CRDT- 2011/11/16 06:00
PHST- 2011/06/20 00:00 [received]
PHST- 2011/10/14 00:00 [accepted]
PHST- 2011/11/16 06:00 [entrez]
PHST- 2011/11/16 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1007/s11948-011-9319-6 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Mar;19(1):43-62. doi: 10.1007/s11948-011-9319-6. Epub 2011
      Nov 15.


PMID- 22083266
OWN - NLM
STAT- MEDLINE
DCOM- 20120814
LR  - 20120516
IS  - 1476-5608 (Electronic)
IS  - 1365-7852 (Linking)
VI  - 15
IP  - 2
DP  - 2012 Jun
TI  - Predictive value in the analysis of RNASEL genotypes in relation to prostate
      cancer.
PG  - 144-9
LID - 10.1038/pcan.2011.56 [doi]
AB  - BACKGROUND: We would like to compare the different RNASEL genotypes with the
      stage of the cancer using parameters such as PSA levels, Gleason score and
      T-stage, and to develop a clinical protocol for the monitoring of the disease for
      trying a better evolution of the patient. METHODS: A total of 231 patients with
      sporadic prostate cancer and 100 of controls were genotyped in RNASEL gene by
      sequencing the exons 1 and 3. A survey of clinical information was collected by a
      specialist following the Helsinki protocol. All patients and controls were
      interviewed by a researcher and signed their informed consent to participation in
      the study, which was approved by Ethics Committee of the hospital. The genetic
      information was processed and collected with an ABI PRISM Genetic Analyser 3130
      using SeqScape software v.2.6. All the patients were analysed by comparing the
      genetic and clinical data. chi(2)-tests, Monte Carlo, Fisher tests and contigency
      tables were performed using SPSS v.15.0 and ARLEQUIN v.3.5 software on patient
      population. RESULTS: Significant differences were found only between patients and
      controls in D541E, R461Q and I97L genotypes, the remainder of the variants did
      not seem relevant to our population in contrast to other populations, such as
      north-Caucasians, Afro Americans and Ashkenazi Jews. The genotypes associated
      with the worst prognoses are G/G in D541E, A/A in R462Q and A/G in I97L. The
      controls were included in our study to determine an approximation of the genotype
      in our population compared with the patients, but they did not account for the
      statistical process. CONCLUSIONS: The genetic profile of patients with this
      cancer combined with other parameters could be used as a prognosis factor in
      deciding to give more radical and frequent treatments, depending on personal
      genotype.
FAU - Alvarez-Cubero, M J
AU  - Alvarez-Cubero MJ
AD  - Laboratory of Genetic Identification, Legal Medicine and Toxicology Department,
      Facultad de Medicina, Universidad de Granada, Granada, Spain. mjesusac@ugr.es
FAU - Entrala, C
AU  - Entrala C
FAU - Fernandez-Rosado, F
AU  - Fernandez-Rosado F
FAU - Martinez-Gonzalez, L J
AU  - Martinez-Gonzalez LJ
FAU - Alvarez, J C
AU  - Alvarez JC
FAU - Suarez, A
AU  - Suarez A
FAU - Lorente, J A
AU  - Lorente JA
FAU - Cozar, J M
AU  - Cozar JM
LA  - eng
PT  - Journal Article
DEP - 20111115
PL  - England
TA  - Prostate Cancer Prostatic Dis
JT  - Prostate cancer and prostatic diseases
JID - 9815755
RN  - EC 3.1.- (Endoribonucleases)
RN  - EC 3.1.26.- (2-5A-dependent ribonuclease)
SB  - IM
MH  - Endoribonucleases/*genetics
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Neoplasm Grading
MH  - Polymorphism, Genetic
MH  - Prognosis
MH  - Prostatic Neoplasms/*genetics/*pathology
EDAT- 2011/11/16 06:00
MHDA- 2012/08/15 06:00
CRDT- 2011/11/16 06:00
PHST- 2011/11/16 06:00 [entrez]
PHST- 2011/11/16 06:00 [pubmed]
PHST- 2012/08/15 06:00 [medline]
AID - pcan201156 [pii]
AID - 10.1038/pcan.2011.56 [doi]
PST - ppublish
SO  - Prostate Cancer Prostatic Dis. 2012 Jun;15(2):144-9. doi: 10.1038/pcan.2011.56.
      Epub 2011 Nov 15.


PMID- 22083045
OWN - NLM
STAT- MEDLINE
DCOM- 20120823
LR  - 20220409
IS  - 1528-3968 (Electronic)
IS  - 0029-6554 (Linking)
VI  - 60
IP  - 3
DP  - 2012 May-Jun
TI  - Altruism in clinical research: coordinators' orientation to their professional
      roles.
PG  - 143-8, 148.e1
LID - 10.1016/j.outlook.2011.10.002 [doi]
AB  - OBJECTIVE: Research coordinators have significant responsibilities in clinical
      trials that often require them to find unique ways to manage their jobs, thus
      reshaping their professional identities. The purpose of this study was to
      identify how research coordinators manage role and ethical conflicts within
      clinical research trials. METHODS: A qualitative study combining observation and 
      63 semistructured interviews at 25 research organizations was used. RESULTS:
      Altruism is a recurring theme in how research coordinators define and view their 
      work. CONCLUSION: Altruism is adopted by research coordinators to: (1) Teach
      patient-subjects the appropriate reasons to participate in clinical research, (2)
      minimize the conflict between research and care, and (3) contest the
      undervaluation of coordinating. Altruism is a strategy used to handle the various
      conflicts they experience in a difficult job, and it has become part of the
      professional identity of clinical research coordinators.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Fisher, Jill A
AU  - Fisher JA
AD  - Center for Biomedical Ethics & Society, Vanderbilt University, Nashville, TN
      37203, USA. jill.fisher@vanderbilt.edu
FAU - Kalbaugh, Corey A
AU  - Kalbaugh CA
LA  - eng
GR  - F31 MH070222/MH/NIMH NIH HHS/United States
GR  - F31 MH070222-01/MH/NIMH NIH HHS/United States
GR  - F31 MH070222-02/MH/NIMH NIH HHS/United States
GR  - 5F31MH070222/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20111113
PL  - United States
TA  - Nurs Outlook
JT  - Nursing outlook
JID - 0401075
SB  - IM
CIN - Nurs Outlook. 2013 Mar-Apr;61(2):67-9. PMID: 23402783
MH  - Adult
MH  - Aged
MH  - *Altruism
MH  - Clinical Nursing Research/*organization & administration
MH  - *Clinical Trials as Topic/ethics
MH  - Conflict, Psychological
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nurse's Role/*psychology
MH  - Nurse-Patient Relations/ethics
MH  - Nursing Methodology Research
MH  - Qualitative Research
MH  - Research Personnel/*psychology
PMC - PMC3288508
MID - NIHMS330437
EDAT- 2011/11/16 06:00
MHDA- 2012/08/24 06:00
CRDT- 2011/11/16 06:00
PHST- 2011/07/07 00:00 [received]
PHST- 2011/09/12 00:00 [revised]
PHST- 2011/10/03 00:00 [accepted]
PHST- 2011/11/16 06:00 [entrez]
PHST- 2011/11/16 06:00 [pubmed]
PHST- 2012/08/24 06:00 [medline]
AID - S0029-6554(11)00307-1 [pii]
AID - 10.1016/j.outlook.2011.10.002 [doi]
PST - ppublish
SO  - Nurs Outlook. 2012 May-Jun;60(3):143-8, 148.e1. doi:
      10.1016/j.outlook.2011.10.002. Epub 2011 Nov 13.


PMID- 22082329
OWN - NLM
STAT- MEDLINE
DCOM- 20120409
LR  - 20191112
IS  - 2212-3938 (Electronic)
IS  - 1574-8847 (Linking)
VI  - 6
IP  - 4
DP  - 2011 Nov
TI  - The clinical pharmacology of short acting analgo-sedatives in neonates.
PG  - 222-6
AB  - Effective pain management remains an important indicator of the quality of care
      provided to neonates, not only from an ethical, but also from a clinical outcome 
      perspective. Significant progresses in non-pharmacological therapies have been
      made. However - in the meanwhile - neonatal practice also evolved. These shifts
      in clinical care also induced in a shift in pharmacodynamic end points, and
      consequently, new pharmacological observations are needed with emphasis on short 
      acting procedural analgo-sedatives. Analgo-sedation in neonates remains a
      balanced decision based on systematic assessment (pharmacodynamics, PD), followed
      by titrated administration of the most appropriate analgesic(s) (PK) with
      subsequent re-assessment (PD) to adapt and further titrate exposure and effects. 
      In this review, we will focus on aspects of the clinical pharmacology
      (pharmacokinetics (PK) and -dynamics) of newly emerging, short acting
      analgo-sedatives (midazolam, propofol, remifentanil, inhalational agents,
      ketamine) in neonates. Based on the currently available information on
      predictability of disposition and the limited pharmacodynamic side effects
      (hemodynamics, neuro-apoptosis), it seems that remifentanil is the most promising
      compound for further evaluation.
FAU - Allegaert, Karel
AU  - Allegaert K
AD  - Neonatal Intensive Care Unit, University Hospitals Leuven, Belgium.
      karel.allegaert@uz.kuleuven.ac.be
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Curr Clin Pharmacol
JT  - Current clinical pharmacology
JID - 101273158
RN  - 0 (Analgesics)
RN  - 0 (Anesthetics, Intravenous)
RN  - 0 (Hypnotics and Sedatives)
SB  - IM
MH  - Analgesics/adverse effects/pharmacokinetics/*pharmacology
MH  - Anesthetics, Intravenous/adverse effects/pharmacokinetics/pharmacology
MH  - Animals
MH  - Humans
MH  - Hypnotics and Sedatives/adverse effects/pharmacokinetics/*pharmacology
MH  - Infant, Newborn
MH  - Pain/*drug therapy
MH  - Quality of Health Care
MH  - Time Factors
EDAT- 2011/11/16 06:00
MHDA- 2012/04/10 06:00
CRDT- 2011/11/16 06:00
PHST- 2010/05/24 00:00 [received]
PHST- 2011/09/29 00:00 [revised]
PHST- 2011/10/02 00:00 [accepted]
PHST- 2011/11/16 06:00 [entrez]
PHST- 2011/11/16 06:00 [pubmed]
PHST- 2012/04/10 06:00 [medline]
AID - BSP/CCP/E-Pub/0061 [pii]
AID - 10.2174/157488411798375912 [doi]
PST - ppublish
SO  - Curr Clin Pharmacol. 2011 Nov;6(4):222-6. doi: 10.2174/157488411798375912.


PMID- 22082060
OWN - NLM
STAT- MEDLINE
DCOM- 20120516
LR  - 20151119
IS  - 1939-1315 (Electronic)
IS  - 0022-3514 (Linking)
VI  - 102
IP  - 2
DP  - 2012 Feb
TI  - Fundamental(ist) attribution error: Protestants are dispositionally focused.
PG  - 281-90
LID - 10.1037/a0026294 [doi]
AB  - Attribution theory has long enjoyed a prominent role in social psychological
      research, yet religious influences on attribution have not been well studied. We 
      theorized and tested the hypothesis that Protestants would endorse internal
      attributions to a greater extent than would Catholics, because Protestantism
      focuses on the inward condition of the soul. In Study 1, Protestants made more
      internal, but not external, attributions than did Catholics. This effect survived
      controlling for Protestant work ethic, need for structure, and intrinsic and
      extrinsic religiosity. Study 2 showed that the Protestant-Catholic difference in 
      internal attributions was significantly mediated by Protestants' greater belief
      in a soul. In Study 3, priming religion increased belief in a soul for
      Protestants but not for Catholics. Finally, Study 4 found that experimentally
      strengthening belief in a soul increased dispositional attributions among
      Protestants but did not change situational attributions. These studies expand the
      understanding of cultural differences in attributions by demonstrating a distinct
      effect of religion on dispositional attributions.
FAU - Li, Yexin Jessica
AU  - Li YJ
AD  - Department of Psychology, Arizona State University, P.O. Box 871104, Tempe AZ
      85287-110, USA.
FAU - Johnson, Kathryn A
AU  - Johnson KA
FAU - Cohen, Adam B
AU  - Cohen AB
FAU - Williams, Melissa J
AU  - Williams MJ
FAU - Knowles, Eric D
AU  - Knowles ED
FAU - Chen, Zhansheng
AU  - Chen Z
LA  - eng
PT  - Journal Article
DEP - 20111114
PL  - United States
TA  - J Pers Soc Psychol
JT  - Journal of personality and social psychology
JID - 0014171
SB  - IM
MH  - Catholicism/psychology
MH  - Female
MH  - Humans
MH  - *Internal-External Control
MH  - Male
MH  - Protestantism/*psychology
MH  - Religion
MH  - *Religion and Psychology
MH  - Surveys and Questionnaires
EDAT- 2011/11/16 06:00
MHDA- 2012/05/17 06:00
CRDT- 2011/11/16 06:00
PHST- 2011/11/16 06:00 [entrez]
PHST- 2011/11/16 06:00 [pubmed]
PHST- 2012/05/17 06:00 [medline]
AID - 2011-26285-001 [pii]
AID - 10.1037/a0026294 [doi]
PST - ppublish
SO  - J Pers Soc Psychol. 2012 Feb;102(2):281-90. doi: 10.1037/a0026294. Epub 2011 Nov 
      14.


PMID- 22081968
OWN - NLM
STAT- MEDLINE
DCOM- 20130110
LR  - 20120806
IS  - 1399-3046 (Electronic)
IS  - 1397-3142 (Linking)
VI  - 16
IP  - 6
DP  - 2012 Sep
TI  - Pediatric liver transplantation - ethical dilemmas in a disabled patient.
PG  - E257-60
LID - 10.1111/j.1399-3046.2011.01592.x [doi]
AB  - Allocation of medical resources, especially resources with absolute scarcity such
      as organs for transplant, is a difficult task. Medical, surgical, and ethical
      considerations should be evaluated. In solid organ transplantation, ethics
      committees are the gate keepers that deal with moral philosophy when moral values
      are in conflict. Often, no good solution to a dilemma in these medical ethics
      exists. Our case presents split living liver donation for retransplantation in a 
      mentally disabled girl, with few medical ethics principles at stake.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Toker, A
AU  - Toker A
AD  - Petach Tikva Ben-Gurion University of the Negev, Department of Health Systems
      Management, Beer-Sheva, Israel. asatoker@gmail.com
FAU - Salzer, L
AU  - Salzer L
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20111115
PL  - Denmark
TA  - Pediatr Transplant
JT  - Pediatric transplantation
JID - 9802574
SB  - IM
MH  - Adult
MH  - Child
MH  - Cognition Disorders/*complications/etiology
MH  - Disabled Persons
MH  - Ethics, Medical
MH  - Family
MH  - Fatal Outcome
MH  - Female
MH  - Graft Rejection
MH  - Humans
MH  - Liver Failure/*complications/*therapy
MH  - Liver Transplantation/*ethics
MH  - Living Donors/*ethics
MH  - Male
MH  - Reoperation
EDAT- 2011/11/16 06:00
MHDA- 2013/01/11 06:00
CRDT- 2011/11/16 06:00
PHST- 2011/11/16 06:00 [entrez]
PHST- 2011/11/16 06:00 [pubmed]
PHST- 2013/01/11 06:00 [medline]
AID - 10.1111/j.1399-3046.2011.01592.x [doi]
PST - ppublish
SO  - Pediatr Transplant. 2012 Sep;16(6):E257-60. doi:
      10.1111/j.1399-3046.2011.01592.x. Epub 2011 Nov 15.


PMID- 22080749
OWN - NLM
STAT- MEDLINE
DCOM- 20120308
LR  - 20111114
IS  - 1555-3892 (Electronic)
IS  - 0963-6897 (Linking)
VI  - 20
IP  - 8
DP  - 2011
TI  - Technology and innovation: 2010 a year in review.
PG  - 1315-9
LID - 10.3727/096368911X593127 [doi]
AB  - The following commentary provides a discussion of the articles published in
      Technology and Innovation in 2010 and where possible places them into context
      with those reported in Cell Transplantation. These articles can be divided into
      the following topics: a) models for innovation and technological
      commercialization, b) the ethical and legal consequences of the emergence of new 
      technologies, c) research on novel technologies and methods, and d) the
      difficulties involved in peer review and scientific assessment. The articles shed
      light on the effects of technological innovation and commercialization on
      scientific ethical regulation, the establishment of legal standards for the
      protection of intellectual property, and the development of financial models.
FAU - Sanberg, Paul R
AU  - Sanberg PR
AD  - Office of Research & Innovation, University of South Florida, Tampa, FL
      33612-9444, USA. psanberg@research.usf.edu
FAU - Vindrola-Padros, Cecilia
AU  - Vindrola-Padros C
FAU - Eve, David J
AU  - Eve DJ
FAU - Federoff, Howard J
AU  - Federoff HJ
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Cell Transplant
JT  - Cell transplantation
JID - 9208854
SB  - IM
MH  - Cell Transplantation/*methods
MH  - Organizational Innovation
MH  - Technology/*methods
EDAT- 2011/11/15 06:00
MHDA- 2012/03/09 06:00
CRDT- 2011/11/15 06:00
PHST- 2011/11/15 06:00 [entrez]
PHST- 2011/11/15 06:00 [pubmed]
PHST- 2012/03/09 06:00 [medline]
AID - 10.3727/096368911X593127 [doi]
PST - ppublish
SO  - Cell Transplant. 2011;20(8):1315-9. doi: 10.3727/096368911X593127.


PMID- 22080542
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111123
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 1
IP  - 2
DP  - 2011 Jan 1
TI  - What determines adherence to treatment in cardiovascular disease prevention?
      Protocol for a mixed methods preference study.
PG  - e000372
LID - 10.1136/bmjopen-2011-000372 [doi]
AB  - Background Significant gaps exist between guidelines-recommended therapies for
      cardiovascular disease prevention and current practice. Fixed-dose combination
      pills ('polypills') potentially improve adherence to therapy. This study is a
      preference study undertaken in conjunction with a clinical trial of a polypill
      and seeks to examine the underlying reasons for variations in treatment adherence
      to recommended therapy. Methods/design A preference study comprising: (1)
      Discrete Choice Experiment for patients; and (2) qualitative study of patients
      and providers. Both components will be conducted on participants in the trial. A 
      joint model combining the observed adherence in the clinical trial (revealed
      preference) and the Discrete Choice Experiment data (stated preference) will be
      estimated. Estimates will be made of the marginal effect (importance) of each
      attribute on overall choice, the extent to which respondents are prepared to
      trade-off one attribute for another and predicted values of the level of
      adherence given a fixed set of attributes, and contextual and socio-demographic
      characteristics. For the qualitative study, a thematic analysis will be used as a
      means of exploring in depth the preferences and ultimately provide important
      narratives on the experiences and perspectives of individuals with regard to
      adherence behaviour. Ethics and dissemination Primary ethics approval was
      received from Sydney South West Area Health Service Human Research Ethics
      Committee (Royal Prince Alfred Hospital zone). In addition to usual scientific
      forums, the findings will be reported back to the communities involved in the
      studies through site-specific reports and oral presentations.
FAU - Jan, Stephen
AU  - Jan S
AD  - George Institute for Global Health, Camperdown, Australia.
FAU - Usherwood, Tim
AU  - Usherwood T
FAU - Brien, Jo Anne
AU  - Brien JA
FAU - Peiris, David
AU  - Peiris D
FAU - Rose, John
AU  - Rose J
FAU - Hayman, Noel
AU  - Hayman N
FAU - Howard, Kirsten
AU  - Howard K
FAU - Redfern, Julie
AU  - Redfern J
FAU - Laba, Tracey
AU  - Laba T
FAU - Cass, Alan
AU  - Cass A
FAU - Patel, Anushka
AU  - Patel A
LA  - eng
PT  - Journal Article
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3211054
EDAT- 2011/11/15 06:00
MHDA- 2011/11/15 06:01
CRDT- 2011/11/15 06:00
PHST- 2011/11/15 06:00 [entrez]
PHST- 2011/11/15 06:00 [pubmed]
PHST- 2011/11/15 06:01 [medline]
AID - bmjopen-2011-000372 [pii]
AID - 10.1136/bmjopen-2011-000372 [doi]
PST - ppublish
SO  - BMJ Open. 2011 Jan 1;1(2):e000372. doi: 10.1136/bmjopen-2011-000372.


PMID- 22080465
OWN - NLM
STAT- MEDLINE
DCOM- 20120501
LR  - 20211021
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 2
DP  - 2012 Feb
TI  - How to write a systematic review of reasons.
PG  - 121-6
LID - 10.1136/medethics-2011-100096 [doi]
AB  - Systematic reviews, which were developed to improve policy-making and clinical
      decision-making, answer an empirical question based on a minimally biased
      appraisal of all the relevant empirical studies. A model is presented here for
      writing systematic reviews of argument-based literature: literature that uses
      arguments to address conceptual questions, such as whether abortion is morally
      permissible or whether research participants should be legally entitled to
      compensation for sustaining research-related injury. Such reviews aim to improve 
      ethically relevant decisions in healthcare, research or policy. They are better
      tools than informal reviews or samples of literature with respect to the
      identification of the reasons relevant to a conceptual question, and they enable 
      the setting of agendas for conceptual and empirical research necessary for sound 
      policy-making. This model comprises prescriptions for writing the systematic
      review's review question and eligibility criteria, the identification of the
      relevant literature, the type of data to extract on reasons and publications, and
      the derivation and presentation of results. This paper explains how to adapt the 
      model to the review question, literature reviewed and intended readers, who may
      be decision-makers or academics. Obstacles to the model's application are
      described and addressed, and limitations of the model are identified.
FAU - Strech, Daniel
AU  - Strech D
AD  - Centre for Ethics and Law in the Life Sciences, Institute of History, Ethics and 
      Philosophy, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, Germany.
      strech.daniel@mh-hannover.de
FAU - Sofaer, Neema
AU  - Sofaer N
LA  - eng
GR  - 088360/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111111
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Decision Making
MH  - Humans
MH  - Policy Making
MH  - Research/organization & administration/standards
MH  - *Research Design
MH  - Review Literature as Topic
MH  - Writing
PMC - PMC3262986
EDAT- 2011/11/15 06:00
MHDA- 2012/05/02 06:00
CRDT- 2011/11/15 06:00
PHST- 2011/11/15 06:00 [entrez]
PHST- 2011/11/15 06:00 [pubmed]
PHST- 2012/05/02 06:00 [medline]
AID - medethics-2011-100096 [pii]
AID - 10.1136/medethics-2011-100096 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Feb;38(2):121-6. doi: 10.1136/medethics-2011-100096. Epub 2011
      Nov 11.


PMID- 22079892
OWN - NLM
STAT- MEDLINE
DCOM- 20120517
LR  - 20161125
IS  - 1095-8304 (Electronic)
IS  - 0195-6663 (Linking)
VI  - 58
IP  - 1
DP  - 2012 Feb
TI  - To eat or not to eat red meat. A closer look at the relationship between
      restrained eating and vegetarianism in college females.
PG  - 319-25
LID - 10.1016/j.appet.2011.10.015 [doi]
AB  - Previous research has suggested that vegetarianism may serve as a mask for
      restrained eating. The purpose of this study was to compare the dietary habits
      and lifestyle behaviors of vegetarians (n=55), pesco-vegetarians (n=28),
      semi-vegetarians (n=29), and flexitarians (n=37), to omnivores (n=91), who do not
      restrict animal products from their diets. A convenience sample of college-age
      females completed questionnaires about their eating habits, food choice
      motivations, and personality characteristics. Results indicated that while
      vegetarians and pesco-vegetarians were more open to new experiences and less food
      neophobic, they were not more restrained than omnivores. Rather semi-vegetarians;
      those who restricted only red meat from their diet, and flexitarians; those who
      occasionally eat red meat, were significantly more restrained than omnivores.
      Whereas food choices of semi-vegetarians and flexitarians were motivated by
      weight control, vegetarians and pesco-vegetarians' food choices were motivated by
      ethical concerns. By focusing specifically on semi-vegetarian and flexitarian
      subgroups, more effective approaches can be developed to ensure that their
      concerns about weight loss do not lead to unhealthful or disordered eating
      patterns.
CI  - Published by Elsevier Ltd.
FAU - Forestell, Catherine A
AU  - Forestell CA
AD  - Psychology Department, The College of William & Mary, P.O. Box 8795,
      Williamsburg, VA 23185-8795, USA. caforestell@wm.edu
FAU - Spaeth, Andrea M
AU  - Spaeth AM
FAU - Kane, Stephanie A
AU  - Kane SA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20111102
PL  - England
TA  - Appetite
JT  - Appetite
JID - 8006808
SB  - IM
MH  - Adolescent
MH  - Adolescent Behavior
MH  - Animals
MH  - Cattle
MH  - Choice Behavior
MH  - *Diet
MH  - Diet Surveys
MH  - Diet, Vegetarian/*statistics & numerical data
MH  - Eating
MH  - *Feeding Behavior
MH  - Female
MH  - Food Preferences
MH  - Humans
MH  - Life Style
MH  - *Meat
MH  - Surveys and Questionnaires
MH  - Weight Loss
MH  - Young Adult
EDAT- 2011/11/15 06:00
MHDA- 2012/05/18 06:00
CRDT- 2011/11/15 06:00
PHST- 2011/06/30 00:00 [received]
PHST- 2011/10/26 00:00 [revised]
PHST- 2011/10/28 00:00 [accepted]
PHST- 2011/11/15 06:00 [entrez]
PHST- 2011/11/15 06:00 [pubmed]
PHST- 2012/05/18 06:00 [medline]
AID - S0195-6663(11)00627-1 [pii]
AID - 10.1016/j.appet.2011.10.015 [doi]
PST - ppublish
SO  - Appetite. 2012 Feb;58(1):319-25. doi: 10.1016/j.appet.2011.10.015. Epub 2011 Nov 
      2.


PMID- 22079623
OWN - NLM
STAT- MEDLINE
DCOM- 20120309
LR  - 20191210
IS  - 1879-1409 (Electronic)
IS  - 0305-4179 (Linking)
VI  - 38
IP  - 1
DP  - 2012 Feb
TI  - Developing the first Bi-National clinical quality registry for burns--lessons
      learned so far.
PG  - 52-60
LID - 10.1016/j.burns.2011.03.005 [doi]
AB  - BACKGROUND: Prior to 2004, Australia and New Zealand lacked a systematic method
      to measure burn incidence, aetiology and quality of care or outcomes for burn
      patients. The Australian and New Zealand Burn Association (ANZBA) commenced the
      Bi-National Burns Registry (Bi-NBR) at that time. As a result of the limitations 
      identified with the registry, ANZBA collaborated with Monash University to
      develop the registry as a clinical quality registry [1]. METHOD: A Steering
      Committee was formed to oversee the conduct and development of the registry. A
      Reference Committee revised the minimum dataset and working parties developed
      clinical quality indicators, and an outcome pilot project. RESULTS: Institutional
      ethics approval has been obtained for 16 out of 17 sites and a formalised
      governance process developed. The minimum dataset was improved and includes
      clinical quality indicators. The Bi-NBR clinical quality registry was launched on
      July 1st 2009. A long-term outcome pilot project has been developed with five
      burn units participating (recruitment commenced October 2009). CONCLUSION:
      Through a rigorous development process, a clinical quality registry for burns has
      been established which allows benchmarking of processes and outcomes between
      units. The intention is that all burns units across Australia and New Zealand
      will contribute to the registry.
CI  - Copyright (c) 2011 Elsevier Ltd and ISBI. All rights reserved.
FAU - Watterson, Dina
AU  - Watterson D
AD  - Department of Epidemiology and Preventive Medicine, Monash University, Melbourne,
      Australia. Dina.Watterson@monash.edu
FAU - Gabbe, Belinda J
AU  - Gabbe BJ
FAU - Cleland, Heather
AU  - Cleland H
FAU - Edgar, Dale
AU  - Edgar D
FAU - Cameron, Peter
AU  - Cameron P
CN  - Members of the Bi-NBR Steering Committee
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111110
PL  - Netherlands
TA  - Burns
JT  - Burns : journal of the International Society for Burn Injuries
JID - 8913178
SB  - IM
MH  - Australia
MH  - Burns/*therapy
MH  - Humans
MH  - New Zealand
MH  - Outcome Assessment, Health Care/*methods/organization & administration
MH  - Quality Indicators, Health Care/*organization & administration/standards
MH  - *Registries
IR  - Bates D
FIR - Bates, Debra
IR  - Bicknell K
FIR - Bicknell, Kathy
IR  - Darton A
FIR - Darton, Anne
IR  - Diwell J
FIR - Diwell, Jan
IR  - Hannaford A
FIR - Hannaford, Andrew
IR  - Harvey J
FIR - Harvey, John
IR  - Kavanagh S
FIR - Kavanagh, Sheila
IR  - Khaurana S
FIR - Khaurana, Sanjeev
IR  - Kimble R
FIR - Kimble, Roy
IR  - Lefter M
FIR - Lefter, Michaela
IR  - McWilliams T
FIR - McWilliams, Tania
IR  - Matthews T
FIR - Matthews, Teresa
IR  - Mustapha A
FIR - Mustapha, Alison
IR  - Perrett T
FIR - Perrett, Tracey
IR  - Picton N
FIR - Picton, Natalie
IR  - Rudd M
FIR - Rudd, Michael
IR  - Maitz P
FIR - Maitz, Peter
IR  - Quinn L
FIR - Quinn, Linda
IR  - Schrale R
FIR - Schrale, Rebecca
IR  - Taylor R
FIR - Taylor, Russell
IR  - Singer Y
FIR - Singer, Yvonne
IR  - Vandervord J
FIR - Vandervord, John
IR  - Wallis B
FIR - Wallis, Belinda
IR  - Wong R
FIR - Wong, Richard
IR  - Wood F
FIR - Wood, Fiona
IR  - Banham C
FIR - Banham, Cynthia
IR  - Calvert P
FIR - Calvert, Phil
IR  - Carr A
FIR - Carr, Aislinn
IR  - Conaglen M
FIR - Conaglen, Margaret
IR  - Connolly S
FIR - Connolly, Siobhan
IR  - Mackie I
FIR - Mackie, Ian
IR  - Fong J
FIR - Fong, Joy
IR  - Forster N
FIR - Forster, Natasha
IR  - Healey T
FIR - Healey, Tanja
IR  - James F
FIR - James, Frances
IR  - Lane A
FIR - Lane, Alicia
IR  - Martin L
FIR - Martin, Lisa
IR  - Nesbit D
FIR - Nesbit, Darren
IR  - Pruyn T
FIR - Pruyn, Tim
IR  - McRae SA
FIR - McRae, Sally-Anne
IR  - Tonkin C
FIR - Tonkin, Catherine
IR  - Wasiak J
FIR - Wasiak, Jason
IR  - Wiggins M
FIR - Wiggins, Mark
EDAT- 2011/11/15 06:00
MHDA- 2012/03/10 06:00
CRDT- 2011/11/15 06:00
PHST- 2010/09/07 00:00 [received]
PHST- 2011/03/08 00:00 [revised]
PHST- 2011/03/10 00:00 [accepted]
PHST- 2011/11/15 06:00 [entrez]
PHST- 2011/11/15 06:00 [pubmed]
PHST- 2012/03/10 06:00 [medline]
AID - S0305-4179(11)00087-8 [pii]
AID - 10.1016/j.burns.2011.03.005 [doi]
PST - ppublish
SO  - Burns. 2012 Feb;38(1):52-60. doi: 10.1016/j.burns.2011.03.005. Epub 2011 Nov 10.


PMID- 22079577
OWN - NLM
STAT- MEDLINE
DCOM- 20120507
LR  - 20211203
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 200
DP  - 2012 Jan 3
TI  - The opiate analgesic buprenorphine decreases proliferation of adult hippocampal
      neuroblasts and increases survival of their progeny.
PG  - 211-22
LID - 10.1016/j.neuroscience.2011.10.039 [doi]
AB  - Although opiate drugs of abuse have been shown to decrease adult hippocampal
      neurogenesis, the impact of opiate analgesics has not been tested. North American
      regulatory boards governing the ethical treatment of experimental animals require
      the administration of analgesics, such as buprenorphine, following minor surgical
      interventions. Here, we show that two commonly used post-operative buprenorphine 
      dosing regimes significantly inhibit the proliferation of doublecortin-positive
      neuroblasts but not other hippocampal stem and progenitor cell populations in
      adult mice. Buprenorphine, administered in schedules of three 0.05 mg/kg
      subcutaneous injections over a single day or seven 0.05 mg/kg injections over a
      3-day period decreased the number of actively proliferating
      5-iodo-2'-deoxyuridine-labeled doublecortin-positive cells for up to 6 days after
      opiate withdrawal. The minimal (three injection), but not standard (seven
      injection), analgesic paradigm also reduced basal indices of hippocampal
      progenitor cell apoptosis and enhanced survival of newly born cells for up to 28 
      days. Taken together, these data provide the first evidence that the routine
      administration of opiate analgesics has transient but long-lasting effects on
      neurogenesis and further emphasize that analgesic dosage and schedule should be
      reported and considered when interpreting the magnitude of neural stem and
      progenitor cell activation in response to in vivo intervention.
CI  - Copyright (c) 2011 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Pettit, A S
AU  - Pettit AS
AD  - Neural Regeneration Laboratory and Ottawa Institute of Systems Biology,
      Department of Biochemistry, Microbiology and Immunology, University of Ottawa,
      ON, Canada.
FAU - Desroches, R
AU  - Desroches R
FAU - Bennett, S A L
AU  - Bennett SA
LA  - eng
GR  - MOP-62826/Canadian Institutes of Health Research/Canada
GR  - TGF-96121/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111030
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Analgesics)
RN  - 0 (Antigens)
RN  - 0 (Doublecortin Domain Proteins)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Neuropeptides)
RN  - 0 (Proteoglycans)
RN  - 0 (chondroitin sulfate proteoglycan 4)
RN  - 40D3SCR4GZ (Buprenorphine)
RN  - EC 4.2.1.11 (Phosphopyruvate Hydratase)
RN  - G34N38R2N1 (Bromodeoxyuridine)
RN  - W78I7AY22C (Deoxyuridine)
SB  - IM
MH  - Adult Stem Cells/*drug effects
MH  - Analgesics/*pharmacology
MH  - Analysis of Variance
MH  - Animals
MH  - Antigens/metabolism
MH  - Bromodeoxyuridine/metabolism
MH  - Buprenorphine/*pharmacology
MH  - Cell Proliferation/*drug effects
MH  - Cell Survival/drug effects
MH  - Deoxyuridine/metabolism
MH  - Doublecortin Domain Proteins
MH  - Glial Fibrillary Acidic Protein
MH  - Hippocampus/*cytology/drug effects
MH  - In Situ Nick-End Labeling
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Microtubule-Associated Proteins/metabolism
MH  - Neurogenesis/*drug effects
MH  - Neuroglia/metabolism
MH  - Neuropeptides/metabolism
MH  - Phosphopyruvate Hydratase/metabolism
MH  - Proteoglycans/metabolism
MH  - Time Factors
EDAT- 2011/11/15 06:00
MHDA- 2012/05/09 06:00
CRDT- 2011/11/15 06:00
PHST- 2011/04/07 00:00 [received]
PHST- 2011/10/15 00:00 [revised]
PHST- 2011/10/24 00:00 [accepted]
PHST- 2011/11/15 06:00 [entrez]
PHST- 2011/11/15 06:00 [pubmed]
PHST- 2012/05/09 06:00 [medline]
AID - S0306-4522(11)01232-2 [pii]
AID - 10.1016/j.neuroscience.2011.10.039 [doi]
PST - ppublish
SO  - Neuroscience. 2012 Jan 3;200:211-22. doi: 10.1016/j.neuroscience.2011.10.039.
      Epub 2011 Oct 30.


PMID- 22079282
OWN - NLM
STAT- MEDLINE
DCOM- 20120510
LR  - 20111206
IS  - 1879-176X (Electronic)
IS  - 0300-5712 (Linking)
VI  - 39 Suppl 2
DP  - 2011 Dec
TI  - Dentistry and population approaches for preventing dental diseases.
PG  - S9-19
LID - 10.1016/j.jdent.2011.10.015 [doi]
AB  - Dental professionals are expected to engage in oral disease prevention, but their
      tools limit the approach to chair side activities based on the common notion that
      the major dental diseases, dental caries, gingivitis and periodontitis, are
      behavioural diseases shaped by individual lifestyles. However, lifestyles also
      have causes and individual behaviours reflect cultural norms, expectations and
      opportunities that are socio-economically determined and structurally maintained.
      Importantly, the effects of the societal and socio-economic determinants reach
      way above their influences as individual attributes, and effective approaches to 
      the prevention and control of oral diseases are aligned with this causal chain.
      Unfortunately, the ethos and philosophy of dentistry is focused to a downstream, 
      patient-centred, curative and rehabilitative approach to oral diseases. Whilst
      such services are needed to care for those who have already suffered the
      consequences of oral diseases, they do not influence population oral health. A
      more balanced distribution of efforts and resources along the whole range of
      intervention points from the downstream curative to the upstream structural
      healthy policy approaches is required if appropriate, evidence-based, effective, 
      cost-effective, sustainable, equitable, universal, comprehensive and ethical
      delivery of health care, including oral health care, is the goal. The
      implementation of healthy policies and sound approaches to population oral health
      will require substantial commitment and political will on the part of the public 
      and their elected officials.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Baelum, Vibeke
AU  - Baelum V
AD  - School of Dentistry, Aarhus University Faculty of Health Sciences, Aarhus,
      Denmark. baelum@soci.au.dk
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111104
PL  - England
TA  - J Dent
JT  - Journal of dentistry
JID - 0354422
SB  - IM
MH  - Dental Caries/prevention & control
MH  - Gingivitis/prevention & control
MH  - Health Behavior
MH  - Health Policy
MH  - *Health Promotion
MH  - Humans
MH  - Life Style
MH  - *Oral Health
MH  - Periodontitis/prevention & control
MH  - *Preventive Dentistry
MH  - Primary Prevention
MH  - Socioeconomic Factors
EDAT- 2011/11/15 06:00
MHDA- 2012/05/11 06:00
CRDT- 2011/11/15 06:00
PHST- 2011/07/07 00:00 [received]
PHST- 2011/10/18 00:00 [revised]
PHST- 2011/10/24 00:00 [accepted]
PHST- 2011/11/15 06:00 [entrez]
PHST- 2011/11/15 06:00 [pubmed]
PHST- 2012/05/11 06:00 [medline]
AID - S0300-5712(11)00263-6 [pii]
AID - 10.1016/j.jdent.2011.10.015 [doi]
PST - ppublish
SO  - J Dent. 2011 Dec;39 Suppl 2:S9-19. doi: 10.1016/j.jdent.2011.10.015. Epub 2011
      Nov 4.


PMID- 22079086
OWN - NLM
STAT- MEDLINE
DCOM- 20120403
LR  - 20111129
IS  - 1873-6386 (Electronic)
IS  - 0160-2527 (Linking)
VI  - 34
IP  - 6
DP  - 2011 Nov-Dec
TI  - The right of caregivers to access health information of relatives with mental
      illness.
PG  - 386-92
LID - 10.1016/j.ijlp.2011.10.002 [doi]
AB  - This article reviews the legal, ethical and practical challenges of complying
      with the Ontario Personal Health Information Protection Act (PHIPA) within the
      context of a Canadian mental health system that is overburdened and under
      resourced. The advent of deinstitutionalization has placed significantly
      increased responsibilities on the families of mentally ill individuals. While
      research evidences that involving family members in the care of their mentally
      ill relatives improves treatment outcomes, mental health practitioners constantly
      face the challenge of engaging family caregivers while also complying with
      privacy laws. The authors propose an Ontario Caregiver Recognition Act (OCRA) to 
      formally recognize family caregivers as informal health information custodians
      based on the practice of other jurisdictions which incorporate the rights of
      family members actively engaged in providing care to their mentally ill
      relatives.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Chan, Billy Wing Yum
AU  - Chan BW
AD  - Law and Mental Health Program, Centre for Addiction and Mental Health, Toronto,
      Canada M6J 1H4.
FAU - O'Brien, Ann-Marie
AU  - O'Brien AM
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111112
PL  - Netherlands
TA  - Int J Law Psychiatry
JT  - International journal of law and psychiatry
JID - 7806862
SB  - IM
MH  - Access to Information/ethics/*legislation & jurisprudence
MH  - Canada
MH  - Caregivers/*legislation & jurisprudence
MH  - Confidentiality/*legislation & jurisprudence
MH  - Deinstitutionalization
MH  - Humans
MH  - Mental Disorders/*nursing
MH  - Ontario
EDAT- 2011/11/15 06:00
MHDA- 2012/04/04 06:00
CRDT- 2011/11/15 06:00
PHST- 2011/11/15 06:00 [entrez]
PHST- 2011/11/15 06:00 [pubmed]
PHST- 2012/04/04 06:00 [medline]
AID - S0160-2527(11)00109-9 [pii]
AID - 10.1016/j.ijlp.2011.10.002 [doi]
PST - ppublish
SO  - Int J Law Psychiatry. 2011 Nov-Dec;34(6):386-92. doi: 10.1016/j.ijlp.2011.10.002.
      Epub 2011 Nov 12.


PMID- 22079009
OWN - NLM
STAT- MEDLINE
DCOM- 20140106
LR  - 20121204
IS  - 1532-3099 (Electronic)
IS  - 0266-6138 (Linking)
VI  - 28
IP  - 6
DP  - 2012 Dec
TI  - Parental duties and prenatal screening: does an offer of prenatal screening lead 
      women to believe that they are morally compelled to test?
PG  - e837-43
LID - 10.1016/j.midw.2011.09.006 [doi]
LID - S0266-6138(11)00139-2 [pii]
AB  - BACKGROUND: in debates around prenatal screening, it is frequently argued that
      responsible parenthood implies the acquisition of all available medical
      information about the health of a fetus, and use of this information to benefit
      the future child. OBJECTIVE: to analyse whether an offer of a prenatal test leads
      women to believe that they are morally obliged to control the health of their
      fetus. DESIGN: a substudy within a randomised controlled trial (RCT) aimed to
      assess the decision-making process of women when confronted with an offer of a
      prenatal screening test. PARTICIPANTS: 111 women participating in an RCT were
      retrospectively asked their views on the meaning of testing within their parental
      duties. FINDINGS: testing was described as a personal option that goes beyond the
      normal parental responsibilities. Participants did not believe that they ought to
      control the health of the fetus or to avoid disability. A duty to test was only
      reported when the birth of a disabled child would have a negative impact on
      family life. CONCLUSION: women's accounts suggest that two main factors are
      involved in making testing morally obligatory: (1) the woman's views on her moral
      duties to her family; and (2) the expected burden of a disabled child on the
      well-being of the family. A family-centred approach would be more suitable to
      assess the moral imperative character of testing than women's ethical views about
      their moral duties towards their unborn child. IMPLICATIONS: a test offer should 
      not be limited to communication of the characteristics of screening and the
      meaning of the test results. In helping women to assess the meaning of testing
      within their parental duties, counselling should include the family situation in 
      which women have to decide, the women's expectations about living with a child
      with Down's syndrome or any other disability, and the women's views on their
      commitments towards their family.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Garcia, Elisa
AU  - Garcia E
AD  - Section of Ethics, Philosophy and the History of Medicine, Scientific Institute
      for Quality of Healthcare, Radboud University Nijmegen Medical Centre, PO 9101,
      6500 HB Nijmegen, The Netherlands. e.garciagonzalez@iq.umcn.nl
FAU - Timmermans, Danielle R M
AU  - Timmermans DR
FAU - van Leeuwen, Evert
AU  - van Leeuwen E
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20111110
PL  - Scotland
TA  - Midwifery
JT  - Midwifery
JID - 8510930
MH  - Adult
MH  - Decision Making
MH  - Female
MH  - Health Behavior
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - *Morals
MH  - Patient Acceptance of Health Care/psychology
MH  - Patient Preference/*psychology
MH  - Pregnancy
MH  - Pregnant Women/*psychology
MH  - Prenatal Diagnosis/methods/*psychology
MH  - Young Adult
EDAT- 2011/11/15 06:00
MHDA- 2014/01/07 06:00
CRDT- 2011/11/15 06:00
PHST- 2011/04/05 00:00 [received]
PHST- 2011/07/19 00:00 [revised]
PHST- 2011/09/16 00:00 [accepted]
PHST- 2011/11/15 06:00 [entrez]
PHST- 2011/11/15 06:00 [pubmed]
PHST- 2014/01/07 06:00 [medline]
AID - S0266-6138(11)00139-2 [pii]
AID - 10.1016/j.midw.2011.09.006 [doi]
PST - ppublish
SO  - Midwifery. 2012 Dec;28(6):e837-43. doi: 10.1016/j.midw.2011.09.006. Epub 2011 Nov
      10.


PMID- 22079000
OWN - NLM
STAT- MEDLINE
DCOM- 20120403
LR  - 20111114
IS  - 1532-6586 (Electronic)
IS  - 0161-4754 (Linking)
VI  - 34
IP  - 9
DP  - 2011 Nov
TI  - Human subject research: reporting ethics approval and informed consent in 3
      chiropractic journals.
PG  - 627-33
LID - 10.1016/j.jmpt.2011.02.008 [doi]
AB  - OBJECTIVE: To date, there have been no reports of ethics board approval or
      informed consent within the chiropractic literature or within chiropractic
      research. The purpose of this study was to assess the reporting of ethics
      approval and informed consent in articles published during the 2008 volume year
      of 3 chiropractic research journals included in PubMed. METHODS: A quantitative
      assessment of the articles published in each journal for the 2008 volume year was
      performed. Information collected included if the article involved human subject
      research, if it reported ethics board approval, and if informed consent was given
      to subjects. Data were collected as descriptive statistics (frequency counts and 
      percentages). RESULTS: In aggregate, 50 articles of a total of 143 published
      involved human subject research (35%). 44 reported ethics board approval (88%),
      and 28 reported that informed consent had been obtained (56%). Forty-five percent
      of articles published in the Journal of Manipulative and Physiological
      Therapeutics involved human subject research (39/87), of which 95% reported
      ethics board approval (37/39) and 64% reported informed consent (25/39); 12.5% of
      articles from the Journal of the Canadian Chiropractic Association involved human
      subject research (5/40), of which 80% reported ethics board approval (4/5) and
      40% reported informed consent (2/5); and 37.5% of articles published in
      Chiropractic and Osteopathy involved human subject research (6/16), of which 50% 
      reported ethics board approval (3/6) and 17% reported informed consent (1/6).
      CONCLUSION: Overall, most articles reported ethics approval, and more than half
      reported consent. This was harmonious with research on this topic from other
      disciplines. This situation indicates a need for continued quality improvement
      and for better instruction and dissemination of information on these issues to
      researchers, to manuscript reviewers, to journal editors, and to the readers.
CI  - Copyright (c) 2011 National University of Health Sciences. Published by Mosby,
      Inc. All rights reserved.
FAU - Lawrence, Dana J
AU  - Lawrence DJ
AD  - Center for Teaching and Learning, Palmer College ofChiropractic, Davenport, IA
      52803, USA. dana.lawrence@palmer.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Manipulative Physiol Ther
JT  - Journal of manipulative and physiological therapeutics
JID - 7807107
SB  - IM
MH  - *Chiropractic
MH  - *Ethics Committees, Clinical
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Informed Consent/*ethics
MH  - *Periodicals as Topic
MH  - Publishing/*ethics/*standards
EDAT- 2011/11/15 06:00
MHDA- 2012/04/04 06:00
CRDT- 2011/11/15 06:00
PHST- 2010/05/24 00:00 [received]
PHST- 2011/01/19 00:00 [revised]
PHST- 2011/01/20 00:00 [accepted]
PHST- 2011/11/15 06:00 [entrez]
PHST- 2011/11/15 06:00 [pubmed]
PHST- 2012/04/04 06:00 [medline]
AID - S0161-4754(11)00031-5 [pii]
AID - 10.1016/j.jmpt.2011.02.008 [doi]
PST - ppublish
SO  - J Manipulative Physiol Ther. 2011 Nov;34(9):627-33. doi:
      10.1016/j.jmpt.2011.02.008.


PMID- 22078890
OWN - NLM
STAT- MEDLINE
DCOM- 20120309
LR  - 20181201
IS  - 1097-6760 (Electronic)
IS  - 0196-0644 (Linking)
VI  - 59
IP  - 2
DP  - 2012 Feb
TI  - Coffers brimming, ethically bankrupt.
PG  - 101-2
LID - 10.1016/j.annemergmed.2011.10.011 [doi]
FAU - Solomon, Robert C
AU  - Solomon RC
LA  - eng
PT  - Editorial
PT  - Comment
DEP - 20111110
PL  - United States
TA  - Ann Emerg Med
JT  - Annals of emergency medicine
JID - 8002646
SB  - IM
CON - Ann Emerg Med. 2012 Feb;59(2):89-97. PMID: 21875761
MH  - Drug Industry/*ethics
MH  - Gift Giving/*ethics
MH  - Humans
MH  - Physicians/*ethics
EDAT- 2011/11/15 06:00
MHDA- 2012/03/10 06:00
CRDT- 2011/11/15 06:00
PHST- 2011/10/05 00:00 [received]
PHST- 2011/10/10 00:00 [revised]
PHST- 2011/10/10 00:00 [accepted]
PHST- 2011/11/15 06:00 [entrez]
PHST- 2011/11/15 06:00 [pubmed]
PHST- 2012/03/10 06:00 [medline]
AID - S0196-0644(11)01695-7 [pii]
AID - 10.1016/j.annemergmed.2011.10.011 [doi]
PST - ppublish
SO  - Ann Emerg Med. 2012 Feb;59(2):101-2. doi: 10.1016/j.annemergmed.2011.10.011. Epub
      2011 Nov 10.


PMID- 22078722
OWN - NLM
STAT- MEDLINE
DCOM- 20120312
LR  - 20220408
IS  - 1474-547X (Electronic)
IS  - 0140-6736 (Linking)
VI  - 379
IP  - 9818
DP  - 2012 Mar 3
TI  - A pilot programme of organ donation after cardiac death in China.
PG  - 862-5
LID - 10.1016/S0140-6736(11)61086-6 [doi]
AB  - China's aims are to develop an ethical and sustainable organ transplantation
      system for the Chinese people and to be accepted as a responsible member of the
      international transplantation community. In 2007, China implemented the
      Regulation on Human Organ Transplantation, which was the first step towards the
      establishment of a voluntary organ donation system. Although progress has been
      made, several ethical and legal issues associated with transplantation in China
      remain, including the use of organs from executed prisoners, organ scarcity, the 
      illegal organ trade, and transplantation tourism. In this Health Policy article
      we outline the standards used to define cardiac death in China and a legal and
      procedural framework for an organ donation system based on voluntary donation
      after cardiac death that adheres to both China's social and cultural principles
      and international transplantation standards.
CI  - Copyright A(c) 2012 Elsevier Ltd. All rights reserved.
FAU - Huang, Jiefu
AU  - Huang J
AD  - Department of Liver Surgery, Peking Union Medical College Hospital, Beijing,
      China. jeffrey1301@hotmail.com
FAU - Millis, J Michael
AU  - Millis JM
FAU - Mao, Yilei
AU  - Mao Y
FAU - Millis, M Andrew
AU  - Millis MA
FAU - Sang, Xinting
AU  - Sang X
FAU - Zhong, Shouxian
AU  - Zhong S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111110
PL  - England
TA  - Lancet
JT  - Lancet (London, England)
JID - 2985213R
SB  - IM
MH  - Advisory Committees
MH  - Brain Death
MH  - *Capital Punishment
MH  - China
MH  - Cultural Characteristics
MH  - *Death
MH  - *Health Policy/legislation & jurisprudence/trends
MH  - Humans
MH  - *Informed Consent
MH  - International Cooperation
MH  - *Living Donors
MH  - Medical Tourism/ethics/trends
MH  - *Organ Transplantation/ethics/legislation & jurisprudence/trends
MH  - Pilot Projects
MH  - *Prisoners
MH  - *Tissue and Organ Procurement/ethics/legislation & jurisprudence/trends
EDAT- 2011/11/15 06:00
MHDA- 2012/03/13 06:00
CRDT- 2011/11/15 06:00
PHST- 2011/11/15 06:00 [entrez]
PHST- 2011/11/15 06:00 [pubmed]
PHST- 2012/03/13 06:00 [medline]
AID - S0140-6736(11)61086-6 [pii]
AID - 10.1016/S0140-6736(11)61086-6 [doi]
PST - ppublish
SO  - Lancet. 2012 Mar 3;379(9818):862-5. doi: 10.1016/S0140-6736(11)61086-6. Epub 2011
      Nov 10.


PMID- 22078281
OWN - NLM
STAT- MEDLINE
DCOM- 20120228
LR  - 20151029
IS  - 0030-6657 (Print)
IS  - 0030-6657 (Linking)
VI  - 65
IP  - 5
DP  - 2011 Sep-Oct
TI  - [Managment of head and neck cancers during pregnancy].
PG  - 326-32
LID - 10.1016/S0030-6657(11)70721-1 [doi]
AB  - The coincidence of malignant disease during pregnancy is uncommon. The incidence 
      of cancer in pregnancy has increased, due to the tendency to postpone childbirth 
      to an older age. Cancer complicates approximately 0.1% of all pregnancies.
      Managing head and neck cancers during pregnancy requires additional
      pregnancy-related understanding of the aetiological effect of pregnancy on
      cancer, knowledge of the direct and indirect effects of cancer on pregnancy, and 
      the effect of diagnostic and treatment modalities on pregnancy. The timing of
      treatment is an important determinant on foetal wellbeing. A multidisciplinary
      approach should be adopted to enable parents and clinicians to make the best
      clinical decision. Clinicians must be cognizant with the ethical dilemmas of
      treatment. In head and neck cancers, pregnancy has no effect on maternal
      prognosis when compared to non-pregnant patients matched by age, cancer stage and
      treatment.
CI  - Copyright (c) 2011 Polish Otolaryngology Society. Published by Elsevier Urban &
      Partner (Poland). All rights reserved.
FAU - Kicinski, Krzysztof
AU  - Kicinski K
FAU - Skorek, Andrzej
AU  - Skorek A
FAU - Stankiewicz, Czeslaw
AU  - Stankiewicz C
LA  - pol
PT  - Editorial
PT  - English Abstract
PT  - Review
TT  - Diagnostyka i terapia nowotworow zlosliwych glowy i szyi u ciezarnych.
PL  - Poland
TA  - Otolaryngol Pol
JT  - Otolaryngologia polska = The Polish otolaryngology
JID - 0404453
SB  - IM
MH  - Adult
MH  - Female
MH  - Head and Neck Neoplasms/*diagnosis/epidemiology/*therapy
MH  - Humans
MH  - *Interdisciplinary Communication
MH  - Laryngeal Neoplasms/diagnosis/therapy
MH  - *Maternal Welfare
MH  - Medical Oncology/methods
MH  - Otolaryngology/methods
MH  - Pregnancy
MH  - Pregnancy Complications, Neoplastic/*diagnosis/epidemiology/*therapy
MH  - Prenatal Care/methods
MH  - Young Adult
EDAT- 2011/11/15 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/11/15 06:00
PHST- 2011/05/20 00:00 [received]
PHST- 2011/06/15 00:00 [accepted]
PHST- 2011/11/15 06:00 [entrez]
PHST- 2011/11/15 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - S0030-6657(11)70721-1 [pii]
AID - 10.1016/S0030-6657(11)70721-1 [doi]
PST - ppublish
SO  - Otolaryngol Pol. 2011 Sep-Oct;65(5):326-32. doi: 10.1016/S0030-6657(11)70721-1.


PMID- 22078258
OWN - NLM
STAT- MEDLINE
DCOM- 20120427
LR  - 20220310
IS  - 1878-4046 (Electronic)
IS  - 1076-6332 (Linking)
VI  - 19
IP  - 2
DP  - 2012 Feb
TI  - INbreast: toward a full-field digital mammographic database.
PG  - 236-48
LID - 10.1016/j.acra.2011.09.014 [doi]
AB  - RATIONALE AND OBJECTIVES: Computer-aided detection and diagnosis (CAD) systems
      have been developed in the past two decades to assist radiologists in the
      detection and diagnosis of lesions seen on breast imaging exams, thus providing a
      second opinion. Mammographic databases play an important role in the development 
      of algorithms aiming at the detection and diagnosis of mammary lesions. However, 
      available databases often do not take into consideration all the requirements
      needed for research and study purposes. This article aims to present and detail a
      new mammographic database. MATERIALS AND METHODS: Images were acquired at a
      breast center located in a university hospital (Centro Hospitalar de S. Joao
      [CHSJ], Breast Centre, Porto) with the permission of the Portuguese National
      Committee of Data Protection and Hospital's Ethics Committee. MammoNovation
      Siemens full-field digital mammography, with a solid-state detector of amorphous 
      selenium was used. RESULTS: The new database-INbreast-has a total of 115 cases
      (410 images) from which 90 cases are from women with both breasts affected (four 
      images per case) and 25 cases are from mastectomy patients (two images per case).
      Several types of lesions (masses, calcifications, asymmetries, and distortions)
      were included. Accurate contours made by specialists are also provided in XML
      format. CONCLUSION: The strengths of the actually presented
      database-INbreast-relies on the fact that it was built with full-field digital
      mammograms (in opposition to digitized mammograms), it presents a wide
      variability of cases, and is made publicly available together with precise
      annotations. We believe that this database can be a reference for future works
      centered or related to breast cancer imaging.
CI  - Copyright (c) 2012 AUR. Published by Elsevier Inc. All rights reserved.
FAU - Moreira, Ines C
AU  - Moreira IC
AD  - Faculdade de Medicina, Alameda Prof. Hernani Monteiro, Universidade do Porto,
      Portugal. icm@estsp.ipp.pt
FAU - Amaral, Igor
AU  - Amaral I
FAU - Domingues, Ines
AU  - Domingues I
FAU - Cardoso, Antonio
AU  - Cardoso A
FAU - Cardoso, Maria Joao
AU  - Cardoso MJ
FAU - Cardoso, Jaime S
AU  - Cardoso JS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111110
PL  - United States
TA  - Acad Radiol
JT  - Academic radiology
JID - 9440159
SB  - IM
MH  - Breast Neoplasms/*diagnostic imaging
MH  - *Databases, Factual
MH  - Female
MH  - Humans
MH  - *Mammography
MH  - Portugal
MH  - Radiology Information Systems/*organization & administration
EDAT- 2011/11/15 06:00
MHDA- 2012/04/28 06:00
CRDT- 2011/11/15 06:00
PHST- 2011/05/04 00:00 [received]
PHST- 2011/09/23 00:00 [revised]
PHST- 2011/09/26 00:00 [accepted]
PHST- 2011/11/15 06:00 [entrez]
PHST- 2011/11/15 06:00 [pubmed]
PHST- 2012/04/28 06:00 [medline]
AID - S1076-6332(11)00451-X [pii]
AID - 10.1016/j.acra.2011.09.014 [doi]
PST - ppublish
SO  - Acad Radiol. 2012 Feb;19(2):236-48. doi: 10.1016/j.acra.2011.09.014. Epub 2011
      Nov 10.


PMID- 22078041
OWN - NLM
STAT- MEDLINE
DCOM- 20120330
LR  - 20181201
IS  - 0151-9638 (Print)
IS  - 0151-9638 (Linking)
VI  - 138
IP  - 11
DP  - 2011 Nov
TI  - [Cultural diversity: ethical issues for the dermatologist].
PG  - 770-6
LID - 10.1016/j.annder.2011.08.001 [doi]
FAU - Petit, A
AU  - Petit A
AD  - Service de dermatologie, hopital Saint-Louis, 1, avenue Claude Vellefaux, 75475
      Paris cedex 10, France. antoine.petit@sls.aphp.fr
FAU - Moyal-Barracco, M
AU  - Moyal-Barracco M
FAU - Reyre, A
AU  - Reyre A
FAU - Moro, M-R
AU  - Moro MR
FAU - Penso-Assathiany, D
AU  - Penso-Assathiany D
CN  - groupe ethique de societe francaise de dermatologie
LA  - fre
PT  - Case Reports
PT  - Congress
PT  - Journal Article
TT  - Diversite culturelle : quelles questions ethiques pour le dermatologue ?
DEP - 20111014
PL  - France
TA  - Ann Dermatol Venereol
JT  - Annales de dermatologie et de venereologie
JID - 7702013
RN  - 0 (Drugs, Chinese Herbal)
SB  - IM
CIN - Ann Dermatol Venereol. 2011 Nov;138(11):723-4. PMID: 22078031
MH  - Algeria/ethnology
MH  - China/ethnology
MH  - Communication Barriers
MH  - *Cultural Diversity
MH  - Culture
MH  - Dermatology/*ethics/legislation & jurisprudence
MH  - Drugs, Chinese Herbal/adverse effects
MH  - Ethnopsychology
MH  - Facial Dermatoses/chemically induced/drug therapy
MH  - Female
MH  - Humans
MH  - Impetigo/etiology
MH  - Infant
MH  - Male
MH  - Middle Aged
MH  - Paris
MH  - *Patient Compliance/psychology
MH  - Photosensitivity Disorders/etiology/psychology
MH  - Physician-Patient Relations/*ethics
MH  - Sexual Abstinence
MH  - Sunlight/adverse effects
MH  - Truth Disclosure/*ethics
MH  - Young Adult
EDAT- 2011/11/15 06:00
MHDA- 2012/03/31 06:00
CRDT- 2011/11/15 06:00
PHST- 2011/06/23 00:00 [received]
PHST- 2011/08/11 00:00 [accepted]
PHST- 2011/11/15 06:00 [entrez]
PHST- 2011/11/15 06:00 [pubmed]
PHST- 2012/03/31 06:00 [medline]
AID - S0151-9638(11)00363-2 [pii]
AID - 10.1016/j.annder.2011.08.001 [doi]
PST - ppublish
SO  - Ann Dermatol Venereol. 2011 Nov;138(11):770-6. doi: 10.1016/j.annder.2011.08.001.
      Epub 2011 Oct 14.


PMID- 22078031
OWN - NLM
STAT- MEDLINE
DCOM- 20120330
LR  - 20181201
IS  - 0151-9638 (Print)
IS  - 0151-9638 (Linking)
VI  - 138
IP  - 11
DP  - 2011 Nov
TI  - [Ethics and medical techniques: a transcultural approach].
PG  - 723-4
LID - 10.1016/j.annder.2011.09.002 [doi]
FAU - Revuz, J
AU  - Revuz J
LA  - fre
PT  - Editorial
PT  - Comment
TT  - Ethique, technique et approche transculturelle.
DEP - 20111005
PL  - France
TA  - Ann Dermatol Venereol
JT  - Annales de dermatologie et de venereologie
JID - 7702013
SB  - IM
CON - Ann Dermatol Venereol. 2011 Nov;138(11):770-6. PMID: 22078041
MH  - *Cultural Diversity
MH  - Dermatology/*ethics
MH  - Female
MH  - Humans
MH  - Male
MH  - *Patient Compliance
MH  - Physician-Patient Relations/*ethics
MH  - Truth Disclosure/*ethics
EDAT- 2011/11/15 06:00
MHDA- 2012/03/31 06:00
CRDT- 2011/11/15 06:00
PHST- 2011/11/15 06:00 [entrez]
PHST- 2011/11/15 06:00 [pubmed]
PHST- 2012/03/31 06:00 [medline]
AID - S0151-9638(11)00360-7 [pii]
AID - 10.1016/j.annder.2011.09.002 [doi]
PST - ppublish
SO  - Ann Dermatol Venereol. 2011 Nov;138(11):723-4. doi: 10.1016/j.annder.2011.09.002.
      Epub 2011 Oct 5.


PMID- 22076855
OWN - NLM
STAT- MEDLINE
DCOM- 20120202
LR  - 20111114
IS  - 0303-7339 (Print)
IS  - 0303-7339 (Linking)
VI  - 53
IP  - 11
DP  - 2011
TI  - [Conditional shared confidentiality with regard to the exchange of information
      between members of a team or network; ethical advice needs to be updated].
PG  - 841-9
AB  - BACKGROUND: Care-givers not only work as a team, but increasingly they also
      participate in networks. This development represents an ethical challenge to the 
      exchange of information and to confidentiality. OBJECTIVE: To revise and update
      earlier advice formulated by the Ethics Committee for Mental Health Care of the
      Brothers of Charity in Flanders, in particular concerning the question of whether
      shared confidentiality can be extended from a team to a network. METHOD: The
      Ethics Committee applied an appropriate method which combined ethical discussion 
      and literature research. RESULTS: The earlier advice is no longer adequate
      because of certain practical and theoretical grounds. The Ethics Committee
      chooses to take a positive view of the developing cooperation between care-givers
      and networks. Consequently, the committee proposes shared confidentiality, but
      links this to five conditions: (1) the care-givers should participate in a
      clearly defined and identifiable team or network, (2) they should have a caring
      task in common, (3) they should be pledged to confidentiality, (4) they should
      consult with the patient and obtain his/her informed consent, (5) they should
      apply 'the filter of relevance'. CONCLUSION: Care-givers can exchange information
      with members of a team or network, but this should be done on the basis of
      conditional shared confidentiality.
FAU - Liegeois, A
AU  - Liegeois A
AD  - Faculteit Theologie en Religiewetenschappen, Sint-Michielsstraat, Leuven, Belgie.
      axel.liegeois@theo.kuleuven.be
FAU - Haekens, A
AU  - Haekens A
FAU - Eneman, M
AU  - Eneman M
LA  - dut
PT  - English Abstract
PT  - Journal Article
TT  - Het voorwaardelijk gedeelde beroepsgeheim bij het uitwisselen van informatie in
      een team of netwerk. Revisie van een ethisch advies.
PL  - Netherlands
TA  - Tijdschr Psychiatr
JT  - Tijdschrift voor psychiatrie
JID - 0423731
SB  - IM
MH  - *Confidentiality/ethics/legislation & jurisprudence/psychology
MH  - *Ethics, Clinical
MH  - *Health Policy
MH  - Humans
MH  - Mental Health Services/ethics/legislation & jurisprudence
MH  - Netherlands
MH  - Patient Care Team/*ethics/legislation & jurisprudence
MH  - Professional-Patient Relations/*ethics
EDAT- 2011/11/15 06:00
MHDA- 2012/02/03 06:00
CRDT- 2011/11/15 06:00
PHST- 2011/11/15 06:00 [entrez]
PHST- 2011/11/15 06:00 [pubmed]
PHST- 2012/02/03 06:00 [medline]
AID - TVPart_9235 [pii]
PST - ppublish
SO  - Tijdschr Psychiatr. 2011;53(11):841-9.


PMID- 22076318
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220129
IS  - 2231-0614 (Print)
IS  - 2231-0614 (Linking)
VI  - 1
IP  - 4
DP  - 2011 Oct
TI  - Expression of ERalpha, its ERalphaDelta3 Splice Variant and gamma-SYNUCLEIN in
      Ovarian Cancer: A Pilot Study.
PG  - 430-444
AB  - AIMS: Ovarian cancer has the highest mortality of any gynaecological malignancy; 
      this is due to rapid peritoneal spread of tumour cells and neovascularization.
      Understanding the mechanisms underlying this is critical to developing early
      diagnostic or treatment strategies. We devised a pilot study to examine the role 
      of gamma-SYNUCLEIN (gamma-SYN), oestrogen receptor (ER)alpha, and the splice
      variant ERalphaDelta3. METHODOLOGY: With ethical approval, ovarian tissue was
      collected from patients (n=24) undergoing oopherectomy for non-ovarian pathology 
      or primary surgery for suspected ovarian cancer. Quantitative gene expression
      analysis was employed for gamma-SYN, ERalpha, and ERalphaDelta3. To identify the 
      in situ localization, immunofluorescence for gamma-syn was carried out. RESULTS: 
      Ovarian tumour tissue exhibited an elevated expression of gamma-SYN and
      high-grade tumours had an elevated ERalphaDelta3:ERalpha ratio compared with
      benign tissue. The majority of previous studies point to the gamma-syn protein
      being present in epithelial cells of high-grade disease. Our study supports this,
      but additionally we conclusively identify its presence in the endothelial cells
      of vasculature surrounding low-grade disease; immunofluorescence was strongest in
      the apical cells surrounding the lumen. CONCLUSION: Our results demonstrate for
      the first time that there are readily-expressed levels of gamma-SYN and
      ERalphaDelta3 in normal ovarian tissue and ovarian tumours. In high-grade
      disease, gamma-syn and an elevated ERalphaDelta3:ERalpha ratio might confer
      metastatic potential to the tumourigenic cells and promote neoangiogenesis.
      Future in vitro studies might be necessary to delineate such a mechanism, which
      could potentially be the basis of early intervention.
FAU - Cheung, Karen T
AU  - Cheung KT
AD  - Centre for Biophotonics, Lancaster Environment Centre, Lancaster University,
      Lancaster LA1 4YQ, UK.
FAU - Taylor, Sian E
AU  - Taylor SE
FAU - Patel, Imran I
AU  - Patel II
FAU - Bentley, Adam J
AU  - Bentley AJ
FAU - Stringfellow, Helen F
AU  - Stringfellow HF
FAU - Fullwood, Nigel J
AU  - Fullwood NJ
FAU - Martin-Hirsch, Pierre L
AU  - Martin-Hirsch PL
FAU - Martin, Francis L
AU  - Martin FL
LA  - eng
GR  - BB/D010055/1/BB_/Biotechnology and Biological Sciences Research Council/United
      Kingdom
PT  - Journal Article
PL  - India
TA  - Br J Med Med Res
JT  - British journal of medicine and medical research
JID - 101570965
PMC - PMC3210401
MID - UKMS36766
EDAT- 2011/11/15 06:00
MHDA- 2011/11/15 06:01
CRDT- 2011/11/15 06:00
PHST- 2011/11/15 06:00 [entrez]
PHST- 2011/11/15 06:00 [pubmed]
PHST- 2011/11/15 06:01 [medline]
AID - 10.9734/bjmmr/2011/769 [doi]
PST - ppublish
SO  - Br J Med Med Res. 2011 Oct;1(4):430-444. doi: 10.9734/bjmmr/2011/769.


PMID- 22075818
OWN - NLM
STAT- MEDLINE
DCOM- 20120604
LR  - 20181201
IS  - 1536-3732 (Electronic)
IS  - 1049-2275 (Linking)
VI  - 22
IP  - 6
DP  - 2011 Nov
TI  - Effects of lidocaine infiltration on cost of rhinoplasty made under general
      anesthesia.
PG  - 2176-8
LID - 10.1097/SCS.0b013e318232414c [doi]
AB  - This study aimed to compare the effects of combined and noncombined lidocaine
      with adrenaline infiltration in general anesthesia (GA) procedures, in which the 
      standard anesthesia depth is monitored by Bispectral Index monitoring, on minimum
      alveolar concentration (MAC) levels and the costs. Following approval by the
      local ethics committee, an American Society of Anesthesiologists physical status 
      I-II group of 40 adult patients for whom elective rhinoplasties under GA were
      planned was divided into 2 double-blind randomized groups. In group 1, GA and
      lidocaine + adrenaline were administered, whereas in group 2, only GA and
      adrenaline were administered. All the patients who had been taken to the
      operation room underwent electrocardiography and measurements of the peripheral
      oxygen saturation, end-tidal carbon dioxide, heart rate, mean blood pressure, and
      Bispectral Index monitoring. Using the operation time and the MAC% values, the
      total consumed inhalation agent amounts were calculated, and the cost difference 
      was determined. The mean blood pressure values were lower in group 1 (P < 0.05). 
      In group 1, the MAC% was 20.83% lower than that of group 2; the consumed
      desflurane amount was 20.29%, and the cost was 20.29% lower than that of group 2 
      (P < 0.05). In rhinoplasties under GA, the lidocaine + adrenaline combination
      infiltration not only decreased inhaled anesthetic requirement and cost but also 
      supported the hemodynamic stability. In addition, surgical satisfaction increased
      in the lidocaine + adrenaline group because of small number of agitated patients 
      during the recovery period.
FAU - Goktas, Ugur
AU  - Goktas U
AD  - Departments of Anesthesiology, Medicine School of Yuzuncu Yil University, Van,
      Turkey.
FAU - Isik, Daghan
AU  - Isik D
FAU - Kati, Ismail
AU  - Kati I
FAU - Atik, Bekir
AU  - Atik B
FAU - Soyoral, Lokman
AU  - Soyoral L
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - J Craniofac Surg
JT  - The Journal of craniofacial surgery
JID - 9010410
RN  - 0 (Anesthetics, Inhalation)
RN  - 0 (Anesthetics, Local)
RN  - 0 (Drug Combinations)
RN  - 98PI200987 (Lidocaine)
RN  - CRS35BZ94Q (Desflurane)
RN  - CYS9AKD70P (Isoflurane)
RN  - YKH834O4BH (Epinephrine)
MH  - Adult
MH  - Analysis of Variance
MH  - Anesthesia, General/*economics
MH  - Anesthetics, Inhalation/*administration & dosage/*economics
MH  - Anesthetics, Local/*administration & dosage/*economics
MH  - Desflurane
MH  - Double-Blind Method
MH  - Drug Combinations
MH  - Epinephrine/*administration & dosage/*economics
MH  - Female
MH  - Hemodynamics
MH  - Humans
MH  - Isoflurane/administration & dosage/*analogs & derivatives/economics
MH  - Lidocaine/*administration & dosage/*economics
MH  - Male
MH  - Monitoring, Intraoperative
MH  - Rhinoplasty/*economics/*methods
EDAT- 2011/11/15 06:00
MHDA- 2012/06/05 06:00
CRDT- 2011/11/15 06:00
PHST- 2011/11/15 06:00 [entrez]
PHST- 2011/11/15 06:00 [pubmed]
PHST- 2012/06/05 06:00 [medline]
AID - 10.1097/SCS.0b013e318232414c [doi]
PST - ppublish
SO  - J Craniofac Surg. 2011 Nov;22(6):2176-8. doi: 10.1097/SCS.0b013e318232414c.


PMID- 22075391
OWN - NLM
STAT- MEDLINE
DCOM- 20111230
LR  - 20211021
IS  - 1097-6833 (Electronic)
IS  - 0022-3476 (Linking)
VI  - 159
IP  - 6
DP  - 2011 Dec
TI  - Ethical considerations associated with clinical use of next-generation sequencing
      in children.
PG  - 879-80.e1
LID - 10.1016/j.jpeds.2011.07.035 [doi]
FAU - Lantos, John D
AU  - Lantos JD
AD  - Department of Pediatrics, University of Missouri-Kansas City School of Medicine, 
      Children's Mercy Hospitals and Clinics, Kansas City, MO 64108, USA.
      jlantos@cmh.edu
FAU - Artman, Michael
AU  - Artman M
FAU - Kingsmore, Stephen F
AU  - Kingsmore SF
LA  - eng
GR  - UL1 TR000001/TR/NCATS NIH HHS/United States
GR  - UL1 RR033179/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Pediatr
JT  - The Journal of pediatrics
JID - 0375410
SB  - IM
MH  - Child
MH  - Genetic Testing/*ethics
MH  - Humans
MH  - Molecular Diagnostic Techniques/*ethics
PMC - PMC4078977
MID - NIHMS569030
EDAT- 2011/11/15 06:00
MHDA- 2011/12/31 06:00
CRDT- 2011/11/15 06:00
PHST- 2011/11/15 06:00 [entrez]
PHST- 2011/11/15 06:00 [pubmed]
PHST- 2011/12/31 06:00 [medline]
AID - S0022-3476(11)00731-1 [pii]
AID - 10.1016/j.jpeds.2011.07.035 [doi]
PST - ppublish
SO  - J Pediatr. 2011 Dec;159(6):879-80.e1. doi: 10.1016/j.jpeds.2011.07.035.


PMID- 22075012
OWN - NLM
STAT- MEDLINE
DCOM- 20120515
LR  - 20220408
IS  - 1460-2393 (Electronic)
IS  - 1460-2393 (Linking)
VI  - 105
IP  - 3
DP  - 2012 Mar
TI  - Advance care planning and the older patient.
PG  - 225-30
LID - 10.1093/qjmed/hcr209 [doi]
AB  - Making treatment decisions for older people is difficult, because of the complex 
      interplay of their multiple co-morbidities, but also because of the fine balance 
      of risks vs. benefit in any chosen management plan. This becomes even more
      difficult when they lose the capacity to tell us what they want, and often in
      such situations we have to rely on information from others in order to make
      decisions based on their best interests. Advance care planning should help with
      making these decisions clearer, based on the documented preferences of what the
      patient would have wanted while capacity was still present. However, such
      documents are still very rarely used, and even if they are, health-care
      professionals are often wary of them for the multitude of ethical and legal
      problems that can arise.
FAU - Aw, D
AU  - Aw D
AD  - Norwich Medical School, Chancellors Drive, University of East Anglia, Norwich,
      NR4 7TJ, Norfolk, UK.
FAU - Hayhoe, B
AU  - Hayhoe B
FAU - Smajdor, A
AU  - Smajdor A
FAU - Bowker, L K
AU  - Bowker LK
FAU - Conroy, S P
AU  - Conroy SP
FAU - Myint, P K
AU  - Myint PK
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111110
PL  - England
TA  - QJM
JT  - QJM : monthly journal of the Association of Physicians
JID - 9438285
SB  - IM
MH  - Advance Care Planning/*ethics/*statistics & numerical data
MH  - Advance Directives/*ethics
MH  - Age Factors
MH  - Aged
MH  - Comorbidity
MH  - Decision Making
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Professional-Patient Relations
EDAT- 2011/11/15 06:00
MHDA- 2012/05/16 06:00
CRDT- 2011/11/15 06:00
PHST- 2011/11/15 06:00 [entrez]
PHST- 2011/11/15 06:00 [pubmed]
PHST- 2012/05/16 06:00 [medline]
AID - hcr209 [pii]
AID - 10.1093/qjmed/hcr209 [doi]
PST - ppublish
SO  - QJM. 2012 Mar;105(3):225-30. doi: 10.1093/qjmed/hcr209. Epub 2011 Nov 10.


PMID- 22074983
OWN - NLM
STAT- MEDLINE
DCOM- 20120626
LR  - 20220321
IS  - 1559-2030 (Electronic)
IS  - 1551-7144 (Linking)
VI  - 33
IP  - 2
DP  - 2012 Mar
TI  - Exact two-stage designs for phase II activity trials with rank-based endpoints.
PG  - 332-41
LID - 10.1016/j.cct.2011.10.008 [doi]
AB  - Features common to phase II clinical trials include limited knowledge of the
      experimental treatment being evaluated, design components reflecting ethical
      considerations, and small to moderate sample sizes as a result of resource
      constraints. It is for these reasons that there exist many two-stage designs
      proposed in the literature for use in this context. The majority of these designs
      are for binary endpoints and based on exact probability calculations, or are for 
      continuous endpoints and rooted in asymptotic approximations to the null
      distribution. We present exact two-stage Mann-Whitney designs in the context of
      two-arm randomized clinical trials. In addition to describing the designs, we
      present tables of decision rules under a variety of assumed realities for use in 
      trial planning.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Wilding, Gregory E
AU  - Wilding GE
AD  - Department of Biostatistics, University at Buffalo, 3435 Main Street, Buffalo, NY
      14214, USA. gwilding@buffalo.edu
FAU - Shan, Guogen
AU  - Shan G
FAU - Hutson, Alan D
AU  - Hutson AD
LA  - eng
PT  - Journal Article
DEP - 20111030
PL  - United States
TA  - Contemp Clin Trials
JT  - Contemporary clinical trials
JID - 101242342
SB  - IM
MH  - Clinical Trials, Phase II as Topic/*methods
MH  - Endpoint Determination/*methods
MH  - Humans
MH  - *Models, Theoretical
MH  - *Research Design
MH  - Sample Size
EDAT- 2011/11/15 06:00
MHDA- 2012/06/27 06:00
CRDT- 2011/11/15 06:00
PHST- 2011/02/28 00:00 [received]
PHST- 2011/09/28 00:00 [revised]
PHST- 2011/10/26 00:00 [accepted]
PHST- 2011/11/15 06:00 [entrez]
PHST- 2011/11/15 06:00 [pubmed]
PHST- 2012/06/27 06:00 [medline]
AID - S1551-7144(11)00265-5 [pii]
AID - 10.1016/j.cct.2011.10.008 [doi]
PST - ppublish
SO  - Contemp Clin Trials. 2012 Mar;33(2):332-41. doi: 10.1016/j.cct.2011.10.008. Epub 
      2011 Oct 30.


PMID- 22074813
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1753-2000 (Electronic)
IS  - 1753-2000 (Linking)
VI  - 5
IP  - 1
DP  - 2011 Nov 10
TI  - The treatment of severe child aggression (TOSCA) study: Design challenges.
PG  - 36
LID - 10.1186/1753-2000-5-36 [doi]
AB  - BACKGROUND: Polypharmacy (the concurrent use of more than one psychoactive drug) 
      and other combination interventions are increasingly common for treatment of
      severe psychiatric problems only partly responsive to monotherapy. This practice 
      and research on it raise scientific, clinical, and ethical issues such as
      additive side effects, interactions, threshold for adding second drug,
      appropriate target measures, and (for studies) timing of randomization. One
      challenging area for treatment is severe child aggression. Commonly-used
      medications, often in combination, include psychostimulants, antipsychotics, mood
      stabilizers, and alpha-2 agonists, which vary considerably in terms of perceived 
      safety and efficacy. RESULTS: In designing our NIMH-funded trial of polypharmacy,
      we focused attention on the added benefit of a second drug (risperidone) to the
      effect of the first (stimulant). We selected these two drugs because their
      associated adverse events might neutralize each other (e.g., sleep delay and
      appetite decrease from stimulant versus sedation and appetite increase from
      antipsychotic). Moreover, there was considerable evidence of efficacy for each
      drug individually for the management of ADHD and child aggression. The study
      sample comprised children (ages 6-12 years) with both diagnosed ADHD and
      disruptive behavior disorder (oppositional-defiant or conduct disorder)
      accompanied by severe physical aggression. In a staged sequence, the medication
      with the least problematic adverse effects (stimulant) was openly titrated in 3
      weeks to optimal effect. Participants whose behavioral symptoms were not
      normalized received additional double-blind medication, either risperidone or
      placebo, by random assignment. Thus children whose behavioral symptoms were
      normalized with stimulant medication were not exposed to an antipsychotic. All
      families participated in an empirically-supported parent training program for
      disruptive behavior, so that the actual comparison was stimulant+parent training 
      versus stimulant+antipsychotic+parent training. CONCLUSIONS: We hope that the
      resolutions of the challenges presented here will be useful to other
      investigators and facilitate much-needed research on child psychiatric
      polypharmacy. TRIAL REGISTRATION: ClinicalTrials.gov NCT00796302.
FAU - Farmer, Cristan A
AU  - Farmer CA
AD  - Nisonger Center, Ohio State University, Columbus, USA. L.Arnold@osumc.edu.
FAU - Arnold, L Eugene
AU  - Arnold LE
FAU - Bukstein, Oscar G
AU  - Bukstein OG
FAU - Findling, Robert L
AU  - Findling RL
FAU - Gadow, Kenneth D
AU  - Gadow KD
FAU - Li, Xiaobai
AU  - Li X
FAU - Butter, Eric M
AU  - Butter EM
FAU - Aman, Michael G
AU  - Aman MG
LA  - eng
SI  - ClinicalTrials.gov/NCT00796302
GR  - UL1 RR025755/RR/NCRR NIH HHS/United States
PT  - Journal Article
DEP - 20111110
PL  - England
TA  - Child Adolesc Psychiatry Ment Health
JT  - Child and adolescent psychiatry and mental health
JID - 101297974
PMC - PMC3231878
EDAT- 2011/11/15 06:00
MHDA- 2011/11/15 06:01
CRDT- 2011/11/15 06:00
PHST- 2011/08/11 00:00 [received]
PHST- 2011/11/10 00:00 [accepted]
PHST- 2011/11/15 06:00 [entrez]
PHST- 2011/11/15 06:00 [pubmed]
PHST- 2011/11/15 06:01 [medline]
AID - 1753-2000-5-36 [pii]
AID - 10.1186/1753-2000-5-36 [doi]
PST - epublish
SO  - Child Adolesc Psychiatry Ment Health. 2011 Nov 10;5(1):36. doi:
      10.1186/1753-2000-5-36.


PMID- 22074770
OWN - NLM
STAT- MEDLINE
DCOM- 20120524
LR  - 20120322
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 4
DP  - 2012 Apr
TI  - When four principles are too many: bloodgate, integrity and an action-guiding
      model of ethical decision making in clinical practice.
PG  - 195-6
LID - 10.1136/medethics-2011-100136 [doi]
AB  - Medical ethical analysis remains dominated by the principlist account first
      proposed by Beauchamp and Childress. This paper argues that the principlist model
      is unreflective of how ethical decisions are taken in clinical practice. Two
      kinds of medical ethical decisions are distinguished: biosocial ethics and
      clinical ethics. It is argued that principlism is an inappropriate model for
      clinical ethics as it is neither sufficiently action-guiding nor does it
      emphasise the professional integrity of the clinician. An alternative model is
      proposed for decision making in the realm of clinical ethics.
FAU - Muirhead, William
AU  - Muirhead W
AD  - Foundation Office, Post Graduate Medical Education Centre, Lincoln County
      Hospital, Greetwell Road, Lincoln, Lincolnshire LN2 5QY, UK.
      will.muirhead@nhs.net
LA  - eng
PT  - Journal Article
DEP - 20111110
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
CIN - J Med Ethics. 2012 Apr;38(4):197-8. PMID: 22438579
MH  - Beneficence
MH  - Bioethics
MH  - Decision Making/*ethics
MH  - Ethical Analysis
MH  - *Ethical Theory
MH  - Ethics, Clinical
MH  - Humans
MH  - Morals
MH  - *Principle-Based Ethics
MH  - Professional Autonomy
MH  - Social Justice/ethics
EDAT- 2011/11/15 06:00
MHDA- 2012/05/25 06:00
CRDT- 2011/11/15 06:00
PHST- 2011/11/15 06:00 [entrez]
PHST- 2011/11/15 06:00 [pubmed]
PHST- 2012/05/25 06:00 [medline]
AID - medethics-2011-100136 [pii]
AID - 10.1136/medethics-2011-100136 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Apr;38(4):195-6. doi: 10.1136/medethics-2011-100136. Epub 2011
      Nov 10.


PMID- 22074571
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111123
LR  - 20211021
IS  - 1749-7922 (Electronic)
IS  - 1749-7922 (Linking)
VI  - 6
IP  - 1
DP  - 2011 Nov 10
TI  - Ten-year experiences with Tracheostomy at a University teaching hospital in
      Northwestern Tanzania: A retrospective review of 214 cases.
PG  - 38
LID - 10.1186/1749-7922-6-38 [doi]
AB  - BACKGROUND: Tracheostomy remains a very important life saving surgical procedure 
      worldwide and particularly in our environment where patients present late in
      upper airway obstruction. Little work has been done on this subject in our
      environment and therefore it was necessary to conduct this study to describe our 
      own experiences with tracheostomy, outlining the common indications and outcome
      of tracheostomized patients in our setting and compare our results with those
      from other centers in the world. METHODS: This was a 10-year retrospective study 
      which was conducted at Bugando Medical Centre from January 2001 to December 2010.
      Data were retrieved from patients' files kept in the Medical record department
      and analyzed using SPSS computer software version 15.0. Ethical approval to
      conduct the study was obtained from relevant authority before the commencement of
      the study. RESULTS: A total of 214 patients were studied. The male to female
      ratio was 3.1: 1. The majority of patients were in the 3rd decade of life. The
      most common indication for tracheostomy was upper airway obstruction secondary to
      traumatic causes in 55.1% of patients, followed by upper airway obstruction due
      to neoplastic causes in 39.3% of cases. The majority of tracheostomies (80.4%)
      were performed as an emergency. Transverse skin crease incision was employed in
      all the cases. Post-tracheostomy complication rate was 21.5%. Complication rate
      was significantly higher in emergency tracheostomy than in electives (P < 0.001).
      The duration of temporary tracheostomy ranged from 8 days to 46 months, with a
      median duration of 4 months. Tracheostomy decannulation was successively
      performed in 72.4% of patients who survived. Mortality rate was 13.6%. The
      mortality was due to their underlying illnesses, none had tracheostomy-related
      mortality. CONCLUSION: Upper airway obstruction secondary to trauma and laryngeal
      tumors still remains the most common indication for tracheostomy in our centre
      and tracheostomy is still a life saving procedure in the surgical management of
      airway despite complications which are seen more commonly in paediatric patients.
      Most of tracheostomy related complications can be avoided by meticulous attention
      to the details of the technique and postoperative tracheostomy care by skilled
      and trained staff.
FAU - Gilyoma, Japhet M
AU  - Gilyoma JM
AD  - Department of Surgery, Weill-Bugando University Colleges of Health Sciences,
      Mwanza, Tanzania.
FAU - Balumuka, Darius D
AU  - Balumuka DD
AD  - Department of Surgery, Weill-Bugando University Colleges of Health Sciences,
      Mwanza, Tanzania.
FAU - Chalya, Phillipo L
AU  - Chalya PL
AD  - Department of Surgery, Weill-Bugando University Colleges of Health Sciences,
      Mwanza, Tanzania.
LA  - eng
PT  - Journal Article
DEP - 20111110
PL  - England
TA  - World J Emerg Surg
JT  - World journal of emergency surgery : WJES
JID - 101266603
PMC - PMC3221617
EDAT- 2011/11/15 06:00
MHDA- 2011/11/15 06:01
CRDT- 2011/11/15 06:00
PHST- 2011/09/26 00:00 [received]
PHST- 2011/11/10 00:00 [accepted]
PHST- 2011/11/15 06:00 [entrez]
PHST- 2011/11/15 06:00 [pubmed]
PHST- 2011/11/15 06:01 [medline]
AID - 1749-7922-6-38 [pii]
AID - 10.1186/1749-7922-6-38 [doi]
PST - epublish
SO  - World J Emerg Surg. 2011 Nov 10;6(1):38. doi: 10.1186/1749-7922-6-38.


PMID- 22074230
OWN - NLM
STAT- MEDLINE
DCOM- 20121217
LR  - 20201210
IS  - 1365-2850 (Electronic)
IS  - 1351-0126 (Linking)
VI  - 19
IP  - 7
DP  - 2012 Sep
TI  - Patient dignity in psychiatric nursing practice.
PG  - 569-76
LID - 10.1111/j.1365-2850.2011.01837.x [doi]
AB  - Professional nurses have an ethical responsibility to protect and preserve the
      patients' dignity. The aim of this study was to describe how nurses experienced
      incidents relating to patients' dignity in a psychiatric nursing practice. A
      hermeneutic approach was used and data were collected using the critical incident
      technique. Data included 77 written critical incidents, which were interpreted by
      using a hermeneutic text interpretation. The findings show preserved
      dignity--caregivers have the courage to be present, and offended dignity -
      caregivers create powerlessness taken away by the patient. These findings show
      that patients' dignity in a psychiatric nursing practice can be preserved when
      caregivers act on their ethical responsibility. When patients' dignity is
      offended, the caregiver has become an inner value conflict, something they have
      been a part of against their own will.
CI  - (c) 2011 Blackwell Publishing.
FAU - Lindwall, L
AU  - Lindwall L
AD  - Department of Nursing, Karlstad University, Sweden. lillemor.lindwall@kau.se
FAU - Boussaid, L
AU  - Boussaid L
FAU - Kulzer, S
AU  - Kulzer S
FAU - Wigerblad, A
AU  - Wigerblad A
LA  - eng
PT  - Journal Article
DEP - 20111026
PL  - England
TA  - J Psychiatr Ment Health Nurs
JT  - Journal of psychiatric and mental health nursing
JID - 9439514
MH  - Humans
MH  - Mental Disorders/nursing
MH  - Nurse-Patient Relations
MH  - Patient Rights/ethics
MH  - *Personhood
MH  - Power, Psychological
MH  - *Psychiatric Nursing/ethics
MH  - Punishment/psychology
MH  - Task Performance and Analysis
EDAT- 2011/11/15 06:00
MHDA- 2012/12/18 06:00
CRDT- 2011/11/15 06:00
PHST- 2011/11/15 06:00 [entrez]
PHST- 2011/11/15 06:00 [pubmed]
PHST- 2012/12/18 06:00 [medline]
AID - 10.1111/j.1365-2850.2011.01837.x [doi]
PST - ppublish
SO  - J Psychiatr Ment Health Nurs. 2012 Sep;19(7):569-76. doi:
      10.1111/j.1365-2850.2011.01837.x. Epub 2011 Oct 26.


PMID- 22073817
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20191112
IS  - 1054-6863 (Print)
IS  - 1054-6863 (Linking)
VI  - 21
IP  - 3
DP  - 2011 Sep
TI  - Global ethics and principlism.
PG  - 251-76
AB  - This article examines the special relation between common morality and particular
      moralities in the four-principles approach and its use for global ethics. It is
      argued that the special dialectical relation between common morality and
      particular moralities is the key to bridging the gap between ethical universalism
      and relativism. The four-principles approach is a good model for a global
      bioethics by virtue of its ability to mediate successfully between universal
      demands and cultural diversity. The principle of autonomy (i.e., the idea of
      individual informed consent), however, does need to be revised so as to make it
      compatible with alternatives such as family- or community-informed consent. The
      upshot is that the contribution of the four-principles approach to global ethics 
      lies in the so-called dialectical process and its power to deal with
      cross-cultural issues against the background of universal demands by joining them
      together.
FAU - Gordon, John-Stewart
AU  - Gordon JS
AD  - Hans Jonas Institute, University of Cologne, Germany.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Kennedy Inst Ethics J
JT  - Kennedy Institute of Ethics journal
JID - 9109135
SB  - IM
MH  - Beneficence
MH  - *Bioethics
MH  - *Cultural Diversity
MH  - Ethical Analysis
MH  - Ethical Relativism
MH  - Humans
MH  - Informed Consent/ethics
MH  - *Internationality
MH  - Personal Autonomy
MH  - *Principle-Based Ethics
MH  - Social Justice
MH  - *Social Values
EDAT- 2011/11/12 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/11/12 06:00
PHST- 2011/11/12 06:00 [entrez]
PHST- 2011/11/12 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1353/ken.2011.0011 [doi]
PST - ppublish
SO  - Kennedy Inst Ethics J. 2011 Sep;21(3):251-76. doi: 10.1353/ken.2011.0011.


PMID- 22073816
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20191112
IS  - 1054-6863 (Print)
IS  - 1054-6863 (Linking)
VI  - 21
IP  - 3
DP  - 2011 Sep
TI  - What it takes to defend deceptive placebo use.
PG  - 219-50
AB  - A complete defense of deceptive placebo use must address this ethical objection: 
      deceptive placebo use violates patient autonomy, because deceiving a patient
      about the placebo nature of a proposed treatment prevents her from giving
      informed consent to the treatment. Unfortunately, this objection isn't always
      recognized and clearly disambiguated from other ethical concerns. I consider how 
      well several bioethicists who write about placebo use have responded to, or
      evaded, this objection. I conclude that defenders of deceptive placebo use
      should, following the lead of Onora O'Neill, argue that deceptive placebo use is 
      compatible with informed consent.
FAU - Barnhill, Anne
AU  - Barnhill A
AD  - Johns Hopkins University, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Kennedy Inst Ethics J
JT  - Kennedy Institute of Ethics journal
JID - 9109135
RN  - 0 (Placebos)
SB  - IM
MH  - Controlled Clinical Trials as Topic/*ethics/*methods
MH  - *Deception
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Moral Obligations
MH  - Patient Rights/ethics
MH  - *Personal Autonomy
MH  - *Placebos
MH  - Researcher-Subject Relations/*ethics
MH  - Therapeutic Misconception
EDAT- 2011/11/12 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/11/12 06:00
PHST- 2011/11/12 06:00 [entrez]
PHST- 2011/11/12 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1353/ken.2011.0015 [doi]
PST - ppublish
SO  - Kennedy Inst Ethics J. 2011 Sep;21(3):219-50. doi: 10.1353/ken.2011.0015.


PMID- 22073799
OWN - NLM
STAT- MEDLINE
DCOM- 20111216
LR  - 20181201
IS  - 0379-5721 (Print)
IS  - 0379-5721 (Linking)
VI  - 32
IP  - 3
DP  - 2011 Sep
TI  - Assessing the impact of micronutrient intervention programs implemented under
      special circumstances--meeting report.
PG  - 256-63
AB  - INTRODUCTION AND OBJECTIVE: The World Food Programme and the Office of the United
      Nations High Commissioner for Refugees organized a meeting of experts to discuss 
      evaluation of micronutrient interventions under special circumstances, such as
      emergency and refugee situations. RESULTS: Multimicronutrient interventions for
      groups with higher needs may include home fortification products for young
      children or supplements for pregnant and lactating women. The choice of
      preparation should be guided by target group needs, evidence of efficacy of a
      product or its compounds, acceptability, and cost-effectiveness. Different
      designs can be used to assess whether an intervention has the desired impact.
      First, program implementation and adherence must be ascertained. Then, impact on 
      micronutrient status can be assessed, but design options are often limited by
      logistic challenges, available budget, security issues, and ethical and practical
      issues regarding nonintervention or placebo groups. Under these conditions, a
      plausibility design using pre- and postintervention cross-sectional surveys, a
      prospective cohort study, or a step-wedge design, which enrolls groups as they
      start receiving the intervention, should be considered. Post hoc comparison of
      groups with different adherence levels may also be useful. Hemoglobin is often
      selected as an impact indicator because it is easily measured and tends to
      respond to change in micronutrient status, especially iron. However, it is not a 
      very specific indicator of micronutrient status, because it is also influenced by
      inflammation, parasitic infestation, physiological status (age, pregnancy),
      altitude, and disorders such as thalassemia and sickle cell disease. CONCLUSION: 
      Given the constraints described above, replicability of impact in different
      contexts is key to the validation of micronutrient interventions.
FAU - de Pee, Saskia
AU  - de Pee S
AD  - Nutrition and HIV/AIDS Policy Unit, Policy and Strategy Division, World Food
      Programme, Via Cesare Giulio Viola 68/70,00148 Rome, Italy. Saskia.depee@wfp.org
FAU - Spiegel, Paul
AU  - Spiegel P
FAU - Kraemer, Klaus
AU  - Kraemer K
FAU - Wilkinson, Caroline
AU  - Wilkinson C
FAU - Bilukha, Oleg
AU  - Bilukha O
FAU - Seal, Andrew
AU  - Seal A
FAU - Macias, Kathy
AU  - Macias K
FAU - Oman, Allison
AU  - Oman A
FAU - Fall, Ahmed Baba
AU  - Fall AB
FAU - Yip, Ray
AU  - Yip R
FAU - West, Keith
AU  - West K
FAU - Zlotkin, Stanley
AU  - Zlotkin S
FAU - Bloem, Martin W
AU  - Bloem MW
LA  - eng
PT  - Congress
PL  - United States
TA  - Food Nutr Bull
JT  - Food and nutrition bulletin
JID - 7906418
RN  - 0 (Hemoglobins)
RN  - 0 (Iron, Dietary)
RN  - 0 (Trace Elements)
SB  - IM
MH  - Adolescent
MH  - Anemia, Iron-Deficiency/*epidemiology/prevention & control
MH  - Child
MH  - Child, Preschool
MH  - Dietary Supplements
MH  - Female
MH  - Food Services/*organization & administration
MH  - Food, Fortified
MH  - Health Promotion/*organization & administration
MH  - Hemoglobins/analysis
MH  - Humans
MH  - Infant
MH  - Iron, Dietary/administration & dosage
MH  - Lactation/drug effects
MH  - Male
MH  - Nutritional Requirements
MH  - Nutritional Status
MH  - Patient Compliance
MH  - Pregnancy
MH  - Prevalence
MH  - Trace Elements/*administration & dosage/*deficiency
EDAT- 2011/11/12 06:00
MHDA- 2011/12/17 06:00
CRDT- 2011/11/12 06:00
PHST- 2011/11/12 06:00 [entrez]
PHST- 2011/11/12 06:00 [pubmed]
PHST- 2011/12/17 06:00 [medline]
AID - 10.1177/156482651103200311 [doi]
PST - ppublish
SO  - Food Nutr Bull. 2011 Sep;32(3):256-63. doi: 10.1177/156482651103200311.


PMID- 22073756
OWN - NLM
STAT- MEDLINE
DCOM- 20111229
LR  - 20111111
IS  - 0440-8888 (Print)
IS  - 0440-8888 (Linking)
VI  - 45
IP  - 3
DP  - 2011 Jul-Sep
TI  - [The Ethics and Deontology division of the French National Council of Medical
      Doctors, eight years of activity, 1993-2001].
PG  - 257-64
AB  - The activity of the division of Ethics and deontology of the French National
      council of medical doctors is analysed by its former president (1993-2001). Among
      a lot of topics, a new version of the professionnal Code of deontology and
      patients' information were the main subjects of reflection and action.
FAU - Hoerni, Bernard
AU  - Hoerni B
AD  - b.hoerni@orange.fr
LA  - fre
PT  - English Abstract
PT  - Historical Article
PT  - Journal Article
TT  - La section "Ethique et deontologie" du Conseil national de l'Ordre des medecins
      Huit ans d'activite, 1993-2001.
PL  - France
TA  - Hist Sci Med
JT  - Histoire des sciences medicales
JID - 0225346
MH  - Ethical Theory/*history
MH  - Ethics, Medical/*history
MH  - France
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Societies, Medical/*history
EDAT- 2011/11/12 06:00
MHDA- 2011/12/30 06:00
CRDT- 2011/11/12 06:00
PHST- 2011/11/12 06:00 [entrez]
PHST- 2011/11/12 06:00 [pubmed]
PHST- 2011/12/30 06:00 [medline]
PST - ppublish
SO  - Hist Sci Med. 2011 Jul-Sep;45(3):257-64.


PMID- 22073538
OWN - NLM
STAT- MEDLINE
DCOM- 20111206
LR  - 20111111
IS  - 0012-7183 (Print)
IS  - 0012-7183 (Linking)
VI  - 127
IP  - 19
DP  - 2011
TI  - [Fruit fly--genetically excellent model animal for research].
PG  - 2063-71
AB  - Drosophila melanogaster, i.e., the fruit fly is a familiar nuisance in late
      summer. For those living in a country plagued by myriads of flying insects, it is
      difficult to think any other model animal as an ethically more suitable research 
      tool. Due to its genetic manipulability, the fruit fly is an excellent research
      model, but mainly due to lack of experience, has been utilized only to a small
      extent in medical research in Finland. For instance, the readily available
      transgenic RNAi strains have made functional, genome-wide screening possible in a
      complete organism or in a designated tissue.
FAU - Valanne, Susanna
AU  - Valanne S
AD  - Tampereen yliopisto biolaaketieteellisen teknologian yksikko.
FAU - Ramet, Mika
AU  - Ramet M
LA  - fin
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Banaanikarpanen--geneettisesti verraton mallielain tutkimukseen.
PL  - Finland
TA  - Duodecim
JT  - Duodecim; laaketieteellinen aikakauskirja
JID - 0373207
SB  - IM
MH  - Animals
MH  - Animals, Genetically Modified
MH  - *Biomedical Research
MH  - Drosophila melanogaster/*genetics
MH  - Finland
MH  - Genetic Techniques
MH  - Genome, Insect
MH  - Models, Animal
EDAT- 2011/11/12 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/11/12 06:00
PHST- 2011/11/12 06:00 [entrez]
PHST- 2011/11/12 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PST - ppublish
SO  - Duodecim. 2011;127(19):2063-71.


PMID- 22072176
OWN - NLM
STAT- MEDLINE
DCOM- 20111229
LR  - 20181201
IS  - 1175-8716 (Electronic)
IS  - 0028-8446 (Linking)
VI  - 124
IP  - 1345
DP  - 2011 Nov 4
TI  - Banning pharmaceutical sponsorship: is ethical apartheid the right road ahead?
PG  - 96-7
FAU - Gravatt, Lance
AU  - Gravatt L
LA  - eng
PT  - Letter
PT  - Comment
DEP - 20111104
PL  - New Zealand
TA  - N Z Med J
JT  - The New Zealand medical journal
JID - 0401067
SB  - IM
CON - N Z Med J. 2011 Oct 14;124(1344):115-6. PMID: 22016176
MH  - *Attitude of Health Personnel
MH  - Drug Industry/*ethics
MH  - Female
MH  - Gift Giving/*ethics
MH  - Humans
MH  - Interprofessional Relations/*ethics
MH  - Male
MH  - *Students, Medical
EDAT- 2011/11/11 06:00
MHDA- 2011/12/30 06:00
CRDT- 2011/11/11 06:00
PHST- 2011/11/11 06:00 [entrez]
PHST- 2011/11/11 06:00 [pubmed]
PHST- 2011/12/30 06:00 [medline]
PST - epublish
SO  - N Z Med J. 2011 Nov 4;124(1345):96-7.


PMID- 22072168
OWN - NLM
STAT- MEDLINE
DCOM- 20111229
LR  - 20141120
IS  - 1175-8716 (Electronic)
IS  - 0028-8446 (Linking)
VI  - 124
IP  - 1345
DP  - 2011 Nov 4
TI  - "Punching above its weight": why New Zealand must maintain leadership in global
      health.
PG  - 64-8
AB  - As a small island nation, with a population of only 4.4 million, and
      geographically isolated from the centres of global power, New Zealand could be
      seen as of marginal relevance to the global health agenda. This paper argues that
      New Zealand has been and should remain a player in global health, even if current
      fiscal constraints may suggest otherwise. Involvement fits with our
      responsibilities and commitments in the Pacific region and our wider interests,
      including ethical international trade, security, global alliances and the
      fundamental protection of health.
FAU - McCool, Judith
AU  - McCool J
AD  - Global Health, School of Population Health, University of Auckland, Private Bag
      92019, Auckland 1142, New Zealand. j.mccool@auckland.ac.nz
FAU - Bullen, Chris
AU  - Bullen C
LA  - eng
PT  - Journal Article
DEP - 20111104
PL  - New Zealand
TA  - N Z Med J
JT  - The New Zealand medical journal
JID - 0401067
SB  - IM
MH  - Commerce
MH  - *Global Health
MH  - *Health Policy
MH  - *Health Priorities
MH  - Humans
MH  - Internationality
MH  - *Leadership
MH  - New Zealand
EDAT- 2011/11/11 06:00
MHDA- 2011/12/30 06:00
CRDT- 2011/11/11 06:00
PHST- 2011/11/11 06:00 [entrez]
PHST- 2011/11/11 06:00 [pubmed]
PHST- 2011/12/30 06:00 [medline]
PST - epublish
SO  - N Z Med J. 2011 Nov 4;124(1345):64-8.


PMID- 22072086
OWN - NLM
STAT- MEDLINE
DCOM- 20120427
LR  - 20211021
IS  - 1438-1435 (Electronic)
IS  - 1070-3004 (Linking)
VI  - 19
IP  - 1
DP  - 2012 Jan
TI  - Negative predictive value of intravenous contrast-enhanced CT of the abdomen for 
      patients presenting to the emergency department with undifferentiated upper
      abdominal pain.
PG  - 19-26
LID - 10.1007/s10140-011-0996-x [doi]
AB  - The purpose of this study is to calculate the negative predictive value (NPV) CT 
      of the abdomen in patients presenting to the emergency department (ED) with
      undifferentiated upper abdominal pain. Approved by the hospital research ethics
      board, this retrospective study examined consecutive patients presenting to the
      ED with undifferentiated upper abdominal pain whose intravenous contrast-enhanced
      CT of the abdomen was reported as "normal" from June 2006-August 2010. Exclusion 
      criteria included active malignancy, trauma, and known inflammatory bowel
      disease. True-negative (TN) vs. false-negative (FN) cases were categorized by
      consensus opinion of radiologist and emergency physician using a composite
      reference standard including clinical, laboratory, imaging, surgery, pathology,
      and patient self-reporting via phone questionnaire. The NPV was calculated with
      confidence intervals of 95%. The TN and FN groups were compared based on gender, 
      age, site of pain, oral contrast use, and laboratory values. One hundred
      twenty-seven patients were included for analysis. The NPV was 64% (95% CI 55-72).
      The FN group had a higher proportion of patients with epigastric pain (p = 0.02) 
      and a lower proportion of patients with left upper quadrant pain (p = 0.02). The 
      WBC, lipase, and ALT were all higher in the FN group compared with the TN group. 
      The most commonly missed pathologies were inflammatory conditions of the biliary 
      tract and upper gastrointestinal systems. The NPV of CT for evaluation of
      undifferentiated upper abdominal pain in the ED was low at 64%. Physicians should
      consider this limitation and the commonly missed pathology when discharging
      patients with a "normal" CT report.
FAU - Ham, Hyungjoo
AU  - Ham H
AD  - Department of Medical Imaging, The Ottawa Hospital, University of Ottawa, ON,
      Canada.
FAU - McInnes, Matthew D F
AU  - McInnes MD
FAU - Woo, Michael
AU  - Woo M
FAU - Lemonde, Sylvie
AU  - Lemonde S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111110
PL  - United States
TA  - Emerg Radiol
JT  - Emergency radiology
JID - 9431227
RN  - 0 (Contrast Media)
SB  - IM
MH  - Abdominal Pain/*diagnostic imaging
MH  - Chi-Square Distribution
MH  - *Contrast Media
MH  - Diagnosis, Differential
MH  - Emergency Service, Hospital
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Retrospective Studies
MH  - Statistics, Nonparametric
MH  - Surveys and Questionnaires
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2011/11/11 06:00
MHDA- 2012/04/28 06:00
CRDT- 2011/11/11 06:00
PHST- 2011/09/12 00:00 [received]
PHST- 2011/10/18 00:00 [accepted]
PHST- 2011/11/11 06:00 [entrez]
PHST- 2011/11/11 06:00 [pubmed]
PHST- 2012/04/28 06:00 [medline]
AID - 10.1007/s10140-011-0996-x [doi]
PST - ppublish
SO  - Emerg Radiol. 2012 Jan;19(1):19-26. doi: 10.1007/s10140-011-0996-x. Epub 2011 Nov
      10.


PMID- 22071697
OWN - NLM
STAT- MEDLINE
DCOM- 20120217
LR  - 20211203
IS  - 1473-2262 (Electronic)
IS  - 1473-2262 (Linking)
VI  - 22
DP  - 2011 Nov 9
TI  - NANOG priming before full reprogramming may generate germ cell tumours.
PG  - 258-74; discussio 274
AB  - Reprogramming somatic cells into a pluripotent state brings patient-tailored,
      ethical controversy-free cellular therapy closer to reality. However, stem cells 
      and cancer cells share many common characteristics; therefore, it is crucial to
      be able to discriminate between them. We generated two induced pluripotent stem
      cell (iPSC) lines, with NANOG pre-transduction followed by OCT3/4, SOX2, and
      LIN28 overexpression. One of the cell lines, CHiPS W, showed normal pluripotent
      stem cell characteristics, while the other, CHiPS A, though expressing
      pluripotency markers, failed to differentiate and gave rise to germ cell-like
      tumours in vivo. Comparative genomic hybridisation analysis of the generated iPS 
      lines revealed that they were genetically more stable than human embryonic stem
      cell counterparts. This analysis proved to be predictive for the differentiation 
      potential of analysed cells. Moreover, the CHiPS A line expressed a lower ratio
      of p53/p21 when compared to CHiPS W. NANOG pre-induction followed by OCT3/4,
      SOX2, MYC, and KLF4 induction resulted in the same tumour-inducing phenotype.
      These results underline the importance of a re-examination of the role of NANOG
      during reprogramming. Moreover, this reprogramming method may provide insights
      into primordial cell tumour formation and cancer stem cell transformation.
FAU - Grad, I
AU  - Grad I
AD  - Department of Obstetrics and Gynaecology, Geneva University Hospitals, Geneva,
      Switzerland.
FAU - Hibaoui, Y
AU  - Hibaoui Y
FAU - Jaconi, M
AU  - Jaconi M
FAU - Chicha, L
AU  - Chicha L
FAU - Bergstrom-Tengzelius, R
AU  - Bergstrom-Tengzelius R
FAU - Sailani, M R
AU  - Sailani MR
FAU - Pelte, M F
AU  - Pelte MF
FAU - Dahoun, S
AU  - Dahoun S
FAU - Mitsiadis, T A
AU  - Mitsiadis TA
FAU - Tohonen, V
AU  - Tohonen V
FAU - Bouillaguet, S
AU  - Bouillaguet S
FAU - Antonarakis, S E
AU  - Antonarakis SE
FAU - Kere, J
AU  - Kere J
FAU - Zucchelli, M
AU  - Zucchelli M
FAU - Hovatta, O
AU  - Hovatta O
FAU - Feki, A
AU  - Feki A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111109
PL  - Switzerland
TA  - Eur Cell Mater
JT  - European cells & materials
JID - 100973416
RN  - 0 (Homeodomain Proteins)
RN  - 0 (KLF4 protein, human)
RN  - 0 (Klf4 protein, mouse)
RN  - 0 (Kruppel-Like Factor 4)
RN  - 0 (Lin28A protein, human)
RN  - 0 (NANOG protein, human)
RN  - 0 (Nanog Homeobox Protein)
RN  - 0 (Octamer Transcription Factor-3)
RN  - 0 (POU5F1 protein, human)
RN  - 0 (RNA-Binding Proteins)
RN  - 0 (SOX2 protein, human)
RN  - 0 (SOXB1 Transcription Factors)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Cell Differentiation
MH  - Cell Line
MH  - Cellular Reprogramming
MH  - Homeodomain Proteins/*metabolism
MH  - Humans
MH  - *Induced Pluripotent Stem Cells/cytology/metabolism
MH  - Karyotype
MH  - Kruppel-Like Factor 4
MH  - Mice
MH  - Mice, SCID
MH  - Nanog Homeobox Protein
MH  - Neoplasms, Germ Cell and Embryonal/*etiology/pathology
MH  - Octamer Transcription Factor-3/biosynthesis/metabolism
MH  - RNA-Binding Proteins/biosynthesis
MH  - SOXB1 Transcription Factors/biosynthesis
MH  - Sequence Analysis, RNA
EDAT- 2011/11/11 06:00
MHDA- 2012/02/18 06:00
CRDT- 2011/11/11 06:00
PHST- 2011/11/11 06:00 [entrez]
PHST- 2011/11/11 06:00 [pubmed]
PHST- 2012/02/18 06:00 [medline]
AID - vol022a20 [pii]
AID - 10.22203/ecm.v022a20 [doi]
PST - epublish
SO  - Eur Cell Mater. 2011 Nov 9;22:258-74; discussio 274. doi: 10.22203/ecm.v022a20.


PMID- 22071342
OWN - NLM
STAT- MEDLINE
DCOM- 20120309
LR  - 20120123
IS  - 1878-5921 (Electronic)
IS  - 0895-4356 (Linking)
VI  - 65
IP  - 3
DP  - 2012 Mar
TI  - Medical journal editors lacked familiarity with scientific publication issues
      despite training and regular exposure.
PG  - 247-52
LID - 10.1016/j.jclinepi.2011.08.003 [doi]
AB  - OBJECTIVE: To characterize medical editors by determining their demographics,
      training, potential sources of conflict of interest (COI), and familiarity with
      ethical standards. STUDY DESIGN AND SETTING: We selected editors of clinical
      medical journals with the highest annual citation rates. One hundred eighty-three
      editors were electronically surveyed (response rate, 52%) on demographics and
      experiences with editorial training, publication ethics, industry, and scientific
      publication organizations. RESULTS: Editors reported formal (76%) and informal
      (89%) training in medical editing topics. Most editors saw publication ethics
      issues (e.g., authorship, COIs) at least once a year. When presented with four
      questions about editorial issues discussed in commonly cited authoritative policy
      sources, performance was poor on topics of authorship (30% answered correctly),
      COI (15%), peer review (16%), and plagiarism (17%). Despite this, confidence
      level in editorial skills on a Likert scale from the beginning to the end of the 
      survey dropped only slightly from 4.2 to 3.9 (P<0.0001). CONCLUSION: Our study
      presents a current look at editors of major clinical medical journals. Most
      editors reported training in medical editing topics, saw ethical issues
      regularly, and were aware of scientific publication organizations, but their
      knowledge of four common and well-disseminated publication ethics topics appears 
      poor.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Wong, Victoria S S
AU  - Wong VS
AD  - Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA.
      vwongmd@gmail.com
FAU - Callaham, Michael L
AU  - Callaham ML
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111108
PL  - United States
TA  - J Clin Epidemiol
JT  - Journal of clinical epidemiology
JID - 8801383
SB  - IM
MH  - Authorship
MH  - Conflict of Interest
MH  - Education, Continuing/standards
MH  - Humans
MH  - Periodicals as Topic/*standards
MH  - Professional Competence/*standards
MH  - Professional Role
MH  - Publishing/*ethics/*standards
EDAT- 2011/11/11 06:00
MHDA- 2012/03/10 06:00
CRDT- 2011/11/11 06:00
PHST- 2010/11/16 00:00 [received]
PHST- 2011/07/10 00:00 [revised]
PHST- 2011/08/08 00:00 [accepted]
PHST- 2011/11/11 06:00 [entrez]
PHST- 2011/11/11 06:00 [pubmed]
PHST- 2012/03/10 06:00 [medline]
AID - S0895-4356(11)00249-6 [pii]
AID - 10.1016/j.jclinepi.2011.08.003 [doi]
PST - ppublish
SO  - J Clin Epidemiol. 2012 Mar;65(3):247-52. doi: 10.1016/j.jclinepi.2011.08.003.
      Epub 2011 Nov 8.


PMID- 22071234
OWN - NLM
STAT- MEDLINE
DCOM- 20121031
LR  - 20220129
IS  - 1461-7196 (Electronic)
IS  - 1363-4593 (Linking)
VI  - 16
IP  - 4
DP  - 2012 Jul
TI  - The use of routinely collected patient data for research: a critical review.
PG  - 448-63
LID - 10.1177/1363459311425513 [doi]
AB  - Over recent years in the UK there has been growing interest in the potential for 
      routinely collected NHS (National Health Service) patient data to be used for
      secondary purposes, facilitated by the potential of increasingly sophisticated
      electronic databases. This article is based on a critically reflective literature
      review which analyses the key debates pertaining to this issue. The work arose in
      the context of a programme of research concerning routine patient data use in
      neonatal care. The article includes analysis of commentary (opinion and ethical
      inquiry) as well as empirically derived claims. It aims to deconstruct the
      knowledge assumptions on which relevant research studies have been based or are
      proposed and it also incorporates ontological position and moral argument.
      Results are presented according to three predominant debates: the prevailing
      claim that all health research benefits civic society; the varieties of informed 
      consent and choices open to patients regarding secondary uses of their data; and 
      the 'rights and responsibilities' of patients when it comes to their data being
      used for research purposes. It examines the relevance of these themes
      specifically to the neonatal context and the implications for our own research,
      concluding that employing an alternative ethical model to the traditional
      professional one might be useful in order to provide a further perspective on the
      issue.
FAU - Foster, Victoria
AU  - Foster V
AD  - School of Nursing, Midwifery and Social Work, University of Manchester,
      Manchester Academic Health Science Centre, Jean McFarlane Building, University
      Place, Oxford Road, Manchester, UK. Victoria.Foster@manchester.ac.uk
FAU - Young, Alys
AU  - Young A
CN  - Medicines for Neonates Investigator Group
FAU - Modi, Neena
AU  - Modi N
FAU - Brocklehurst, Peter
AU  - Brocklehurst P
FAU - Abbott, Jane
AU  - Abbott J
FAU - Costeloe, Kate
AU  - Costeloe K
FAU - Field, David
AU  - Field D
FAU - Majeed, Azeem
AU  - Majeed A
FAU - Kemp, Jacquie
AU  - Kemp J
FAU - Ashby, Deborah
AU  - Ashby D
FAU - Young, Alys
AU  - Young A
FAU - Petrou, Stavros
AU  - Petrou S
LA  - eng
GR  - RP-PG-0707-10010/DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20111109
PL  - England
TA  - Health (London)
JT  - Health (London, England : 1997)
JID - 9800465
SB  - IM
MH  - Choice Behavior
MH  - Confidentiality
MH  - Databases, Factual/*ethics
MH  - Electronic Health Records/ethics
MH  - Humans
MH  - Informed Consent
MH  - *Patients
MH  - Public Opinion
MH  - *Research
MH  - State Medicine
MH  - United Kingdom
EDAT- 2011/11/11 06:00
MHDA- 2012/11/01 06:00
CRDT- 2011/11/11 06:00
PHST- 2011/11/11 06:00 [entrez]
PHST- 2011/11/11 06:00 [pubmed]
PHST- 2012/11/01 06:00 [medline]
AID - 1363459311425513 [pii]
AID - 10.1177/1363459311425513 [doi]
PST - ppublish
SO  - Health (London). 2012 Jul;16(4):448-63. doi: 10.1177/1363459311425513. Epub 2011 
      Nov 9.


PMID- 22071117
OWN - NLM
STAT- MEDLINE
DCOM- 20120913
LR  - 20120521
IS  - 1879-0046 (Electronic)
IS  - 0376-8716 (Linking)
VI  - 123
IP  - 1-3
DP  - 2012 Jun 1
TI  - Motivators and barriers influencing willingness to participate in candidate HCV
      vaccine trials: perspectives of people who inject drugs.
PG  - 35-40
LID - 10.1016/j.drugalcdep.2011.10.009 [doi]
AB  - BACKGROUND: A safe and efficacious vaccine may be the most efficient and
      cost-effective strategy for controlling the hepatitis C virus (HCV) epidemic
      among people who inject drugs (PWID) and several candidates are in development.
      However, little is known about the factors that influence willingness to
      participate (WTP) in candidate HCV vaccine trials among this group. METHODS: HCV 
      seronegative PWID recruited between 2008 and 2010 as part of a prospective
      observational cohort study in Sydney, Australia were asked whether they would be 
      willing to participate in a future candidate hepatitis C vaccine trial and to
      provide reasons to explain their decision. RESULTS: Of 113 participants, 74%
      indicated WTP, 15% were unwilling to participate and 11% reported WTP that was
      contingent on vaccine characteristics and trial design issues. The most commonly 
      reported motivator for hypothetical trial participation was altruism, followed by
      potential health benefits, financial remuneration, and knowledge gain. Barriers
      to hypothetical participation included fears about possible harms to health, such
      as concerns about vaccine safety, side effects, and acquiring HCV from the
      vaccine; other barriers included mistrust of biomedical research and time
      constraints. CONCLUSIONS: These results may be useful in designing strategies to 
      enhance HCV vaccine trial recruitment and retention and have ethical implications
      for developing informed consent processes and standards of care.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Park, Ju Nyeong
AU  - Park JN
AD  - The Kirby Institute, University of New South Wales, Centre for Immunology, Cnr
      Boundary and West Streets, Darlinghurst, NSW 2010, Australia.
FAU - White, Bethany
AU  - White B
FAU - Bates, Anna
AU  - Bates A
FAU - Enriquez, Jarliene
AU  - Enriquez J
FAU - Liao, Len
AU  - Liao L
FAU - Maher, Lisa
AU  - Maher L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111108
PL  - Ireland
TA  - Drug Alcohol Depend
JT  - Drug and alcohol dependence
JID - 7513587
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Adult
MH  - Altruism
MH  - Cohort Studies
MH  - Fear
MH  - Female
MH  - Health
MH  - Health Knowledge, Attitudes, Practice
MH  - Hepacivirus/*immunology
MH  - Hepatitis C/immunology/*prevention & control
MH  - Humans
MH  - Male
MH  - Motivation
MH  - New South Wales
MH  - Patient Education as Topic
MH  - Research Subjects/economics/*psychology
MH  - Risk
MH  - Safety
MH  - Substance Abuse, Intravenous
MH  - Viral Vaccines/*therapeutic use
MH  - Young Adult
EDAT- 2011/11/11 06:00
MHDA- 2012/09/14 06:00
CRDT- 2011/11/11 06:00
PHST- 2011/08/26 00:00 [received]
PHST- 2011/10/13 00:00 [revised]
PHST- 2011/10/13 00:00 [accepted]
PHST- 2011/11/11 06:00 [entrez]
PHST- 2011/11/11 06:00 [pubmed]
PHST- 2012/09/14 06:00 [medline]
AID - S0376-8716(11)00445-5 [pii]
AID - 10.1016/j.drugalcdep.2011.10.009 [doi]
PST - ppublish
SO  - Drug Alcohol Depend. 2012 Jun 1;123(1-3):35-40. doi:
      10.1016/j.drugalcdep.2011.10.009. Epub 2011 Nov 8.


PMID- 22071003
OWN - NLM
STAT- MEDLINE
DCOM- 20121017
LR  - 20120514
IS  - 1095-8320 (Electronic)
IS  - 1045-1056 (Linking)
VI  - 40
IP  - 3
DP  - 2012 May
TI  - The ethics of blood donation: does altruism suffice?
PG  - 170-2
LID - 10.1016/j.biologicals.2011.10.005 [doi]
AB  - Is the recommendation of the WHO, endorsed by all member states, that all blood
      donations should be voluntary and non-compensated ethically coherent and
      realizable in practice? In a recent paper, Farrugia et al have argued for a
      plurality of both compensated and non-compensated systems, claiming that, from
      both an ethical and practical perspective, the classical concept of the 'the gift
      relationship', advocated over 40 years ago by Richard Titmuss, is unnecessary and
      inadequate. This paper focuses on the ethical aspects of this debate, considering
      the concepts of altruism, reciprocity and social solidarity as they apply to the 
      procurement of blood and blood products, as well as evidence regarding safety of 
      different sources of blood and the motivations of regular donors. It concludes
      with a discussion of the view summarized in a recent publication by Campbell
      (2009), that, although the body may be monetized, doing so would result in a loss
      of human value.
CI  - Copyright (c) 2011 The International Alliance for Biological Standardization.
      Published by Elsevier Ltd. All rights reserved.
FAU - Campbell, Alastair V
AU  - Campbell AV
AD  - National University of Singapore, Centre for Biomedical Ethics, Yong Loo Lin
      School of Medicine, Singapore, Singapore. medavc@nus.edu.sg
FAU - Tan, Cecilia
AU  - Tan C
FAU - Boujaoude, F Elias
AU  - Boujaoude FE
LA  - eng
PT  - Journal Article
DEP - 20111108
PL  - England
TA  - Biologicals
JT  - Biologicals : journal of the International Association of Biological
      Standardization
JID - 9004494
SB  - IM
MH  - *Altruism
MH  - Blood Donors/*ethics/*psychology
MH  - Humans
MH  - Motivation
EDAT- 2011/11/11 06:00
MHDA- 2012/10/18 06:00
CRDT- 2011/11/11 06:00
PHST- 2011/10/05 00:00 [received]
PHST- 2011/10/18 00:00 [accepted]
PHST- 2011/11/11 06:00 [entrez]
PHST- 2011/11/11 06:00 [pubmed]
PHST- 2012/10/18 06:00 [medline]
AID - S1045-1056(11)00180-1 [pii]
AID - 10.1016/j.biologicals.2011.10.005 [doi]
PST - ppublish
SO  - Biologicals. 2012 May;40(3):170-2. doi: 10.1016/j.biologicals.2011.10.005. Epub
      2011 Nov 8.


PMID- 22070468
OWN - NLM
STAT- MEDLINE
DCOM- 20141006
LR  - 20220408
IS  - 1369-7625 (Electronic)
IS  - 1369-6513 (Linking)
VI  - 17
IP  - 1
DP  - 2014 Feb
TI  - Patient involvement in mental health care: one size does not fit all.
PG  - 138-50
LID - 10.1111/j.1369-7625.2011.00743.x [doi]
AB  - BACKGROUND: Involvement of mental health-care patients in the decision-making
      processes is considered to be an ethical requirement. Health-care systems
      worldwide are increasingly emphasizing the value of participatory approaches.
      There is, however, no consensus on the definition of patient involvement. The
      literature is particularly inconsistent and lacks clarity. OBJECTIVE: The purpose
      of this article is to clarify the concept of patient involvement in mental health
      care (MHC), taking into account its multidimensional nature. SEARCH STRATEGY: We 
      searched the literature in online databases from January 1998 until August 2010
      using synonyms of 'patient involvement', combined with the terms 'mental
      health(care)'. DATA SYNTHESIS: Based on 45 different descriptions found in the
      literature, we constructed a definition of patient involvement and we drew up a
      model identifying its determinants and outcomes. RESULTS: We propose a
      comprehensive model of patient involvement to be used in MHC. This model can
      serve as a guide for policy makers and field workers to shape policies to
      stimulate involvement. DISCUSSION AND CONCLUSIONS: There are three main problems 
      in the literature concerning patient involvement. First, there is a proliferation
      of conceptualizations of the topic, leading to conceptual vagueness. Furthermore,
      there is a lack of quantitative data, and some aspects of involvement remain
      underexposed, such as the involvement of specific target groups and practical
      ways to shape the involvement processes. Involvement processes should be tailored
      to the specific target group and context.
CI  - (c) 2011 John Wiley & Sons Ltd.
FAU - Tambuyzer, Else
AU  - Tambuyzer E
AD  - PhD student, LUCAS - Katholieke Universiteit Leuven, LeuvenSenior Lecturer,
      University Psychiatric Centre at Kortenberg, Katholieke Universiteit Leuven,
      LeuvenProfessor, Dr in Psychology, Director, LUCAS - Katholieke Universiteit
      Leuven, Centre for Care Research and Consultancy, Leuven, Belgium.
FAU - Pieters, Guido
AU  - Pieters G
FAU - Van Audenhove, Chantal
AU  - Van Audenhove C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111110
PL  - England
TA  - Health Expect
JT  - Health expectations : an international journal of public participation in health 
      care and health policy
JID - 9815926
SB  - IM
MH  - Attitude of Health Personnel
MH  - Communication
MH  - Cooperative Behavior
MH  - *Decision Making
MH  - Humans
MH  - Mental Health Services/*organization & administration
MH  - Patient Education as Topic
MH  - Patient Participation/*methods
MH  - Power, Psychological
MH  - Quality of Life
PMC - PMC5060706
OTO - NOTNLM
OT  - empowerment
OT  - mental health care
OT  - patient involvement
OT  - patient participation
EDAT- 2011/11/11 06:00
MHDA- 2014/10/07 06:00
CRDT- 2011/11/11 06:00
PHST- 2011/11/11 06:00 [entrez]
PHST- 2011/11/11 06:00 [pubmed]
PHST- 2014/10/07 06:00 [medline]
AID - 10.1111/j.1369-7625.2011.00743.x [doi]
PST - ppublish
SO  - Health Expect. 2014 Feb;17(1):138-50. doi: 10.1111/j.1369-7625.2011.00743.x. Epub
      2011 Nov 10.


PMID- 22070455
OWN - NLM
STAT- MEDLINE
DCOM- 20121214
LR  - 20120806
IS  - 1471-6712 (Electronic)
IS  - 0283-9318 (Linking)
VI  - 26
IP  - 3
DP  - 2012 Sep
TI  - Care as a matter of courage: vulnerability, suffering and ethical formation in
      nursing care.
PG  - 427-35
LID - 10.1111/j.1471-6712.2011.00944.x [doi]
AB  - The aim of the study was to explore nurses' experience of how their own
      vulnerability and suffering influence their ethical formation and their capacity 
      to provide professional care when they are confronted with the patient's
      vulnerability and suffering. Care is shaped in the meeting between human beings. 
      Professional care is informed by the patient's appeal for help as it is expressed
      in the meeting. Ethical formation is understood as a personal ethical and
      existential process, resulting in the capacity to provide professional care. A
      nurse must have the sense of being a complete human being with own personal
      attributes and sensitivity in order to be able to relate to other people. The
      study is based on qualitative interviews with 23 experienced nurses from Sweden, 
      Finland and Denmark. The analyses and interpretation were carried out in line
      with Steinar Kvale's three levels of interpretation. The study clarifies that
      ethical formation is a union of the nurse's personal attributes and professional 
      qualifications and that ethical formation is developed over time. Moreover, it
      also demonstrates that the nurse's personal and professional life experiences of 
      vulnerability and suffering influence ethical formation. Vulnerability and
      suffering have proven to be sensitive issues for nurses, like a sore point that
      either serve as an eye-opener or cause the development of blind spots.
      Furthermore, vulnerability, suffering and the sore points are seen to shape the
      nurse's courage in relation to care. Courage appears to be a significant unifying
      phenomenon that manifests itself as the courage to help patients face their own
      vulnerability and suffering, to bear witness to patients' vulnerability and
      suffering and to have faith in oneself in arguing for and providing professional 
      care. Courage thus seems to play a significant role in nurses' ability to engage 
      in care. Nurses' own vulnerability, suffering and sore points seem to shape their
      courage.
CI  - (c) 2011 The Authors. Scandinavian Journal of Caring Sciences (c) 2011 Nordic
      College of Caring Science.
FAU - Thorup, Charlotte B
AU  - Thorup CB
AD  - Aalborg Hospital, Aarhus University Hospital, Aarhus, Denmark.
FAU - Rundqvist, Ewa
AU  - Rundqvist E
FAU - Roberts, Christel
AU  - Roberts C
FAU - Delmar, Charlotte
AU  - Delmar C
LA  - eng
PT  - Journal Article
DEP - 20111110
PL  - Sweden
TA  - Scand J Caring Sci
JT  - Scandinavian journal of caring sciences
JID - 8804206
MH  - *Ethics, Nursing
MH  - Humans
MH  - *Nursing Care
MH  - Vulnerable Populations
EDAT- 2011/11/11 06:00
MHDA- 2012/12/15 06:00
CRDT- 2011/11/11 06:00
PHST- 2011/11/11 06:00 [entrez]
PHST- 2011/11/11 06:00 [pubmed]
PHST- 2012/12/15 06:00 [medline]
AID - 10.1111/j.1471-6712.2011.00944.x [doi]
PST - ppublish
SO  - Scand J Caring Sci. 2012 Sep;26(3):427-35. doi: 10.1111/j.1471-6712.2011.00944.x.
      Epub 2011 Nov 10.


PMID- 22070443
OWN - NLM
STAT- MEDLINE
DCOM- 20120419
LR  - 20151119
IS  - 1557-7708 (Electronic)
IS  - 1075-5535 (Linking)
VI  - 17
IP  - 11
DP  - 2011 Nov
TI  - Attitude of conventional and CAM physicians toward CAM in India.
PG  - 1069-73
LID - 10.1089/acm.2010.0407 [doi]
AB  - OBJECTIVES: The aim of the present study was to compare the attitude toward
      complementary and alternative medicine (CAM) of primary care physicians trained
      in conventional medicine with CAM physicians whose training was for a comparable 
      duration. The CAM physicians included practitioners of Ayurveda, homeopathy, and 
      naturopathy. PARTICIPANTS: Two hundred and ninety five (295) physicians with aged
      20-60 (group mean+/-standard deviation, 48.2-12.3 years, 87 females)
      participated. Eighty-six (86) of them were trained in Ayurveda, 90 in homeopathy,
      82 in conventional medicine, and 37 in naturopathy. They were attending a 4-day
      residential program on Indian culture. All of them gave their signed consent to
      take part in the study, and the institution's ethics committee approved the
      study. STUDY DESIGN: The study was a cross-sectional survey. Since the
      participants had self-selected to join for the program on Indian culture, the
      sampling could be considered as convenience sampling. RESULTS: The number of
      conventionally trained and CAM physicians were similar in number and in their
      reasons for selecting CAM treatments. CONCLUSIONS: Conventionally trained and CAM
      physicians were comparably likely to prescribe CAM treatments for their patients.
      Their reasons for prescribing CAM treatments appeared to be (1) the idea that CAM
      treatments deal with the cause, and (2) a belief in the treatments. A limiting
      factor of the survey is that it did not determine whether the belief was based on
      evidence or on faith alone.
CI  - (c) Mary Ann Liebert, Inc.
FAU - Telles, Shirley
AU  - Telles S
AD  - Patanjali Yogpeeth, Haridwar, Uttarakhand, India. pyp.research@gmail.com
FAU - Gaur, Vaishali
AU  - Gaur V
FAU - Sharma, Sachin
AU  - Sharma S
FAU - Balkrishna, Acharya
AU  - Balkrishna A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111109
PL  - United States
TA  - J Altern Complement Med
JT  - Journal of alternative and complementary medicine (New York, N.Y.)
JID - 9508124
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - *Complementary Therapies
MH  - Cross-Sectional Studies
MH  - Culture
MH  - Female
MH  - Homeopathy
MH  - Humans
MH  - India
MH  - Male
MH  - Medicine, Ayurvedic
MH  - Middle Aged
MH  - Motivation
MH  - Naturopathy
MH  - *Physicians/psychology
MH  - *Practice Patterns, Physicians'
MH  - Primary Health Care
MH  - Young Adult
EDAT- 2011/11/11 06:00
MHDA- 2012/04/20 06:00
CRDT- 2011/11/11 06:00
PHST- 2011/11/11 06:00 [entrez]
PHST- 2011/11/11 06:00 [pubmed]
PHST- 2012/04/20 06:00 [medline]
AID - 10.1089/acm.2010.0407 [doi]
PST - ppublish
SO  - J Altern Complement Med. 2011 Nov;17(11):1069-73. doi: 10.1089/acm.2010.0407.
      Epub 2011 Nov 9.


PMID- 22069934
OWN - NLM
STAT- MEDLINE
DCOM- 20111209
LR  - 20111110
IS  - 1077-3525 (Print)
IS  - 1077-3525 (Linking)
VI  - 17
IP  - 4
DP  - 2011 Oct-Dec
TI  - Employability and HIV infection: can the military claim to be an exception?
PG  - 352-60
AB  - To determine whether policies that exclude HIV-positive recruits from military
      service are scientifically and ethically justified, we reviewed the literature
      for evidence regarding their capacity to undertake rigorous exercise, the risks
      and benefits of exercise regimes, their risks from opportunistic infections and
      the extra burden of care, within military contexts. The literature suggests that 
      HIV-infected persons with CD4 counts within the normal range have the exercise
      capacity and training benefits similar to uninfected persons. Subjects with
      modest CD4 depression are capable of moderate to strenuous exercise, without
      adverse consequences. Risks from opportunistic infections are mitigated with
      normal CD4 counts. Neurobehavioral impairment in asymptomatic HNV-positive
      patients is unlikely to reduce work capacity for most military occupations and
      can be easily identified by appropriate neurobehavioral testing. HIV testing
      alone is poorly predictive of competencies required for military employment.
      Testing should be used to promote access to care. Use for exclusionary purposes
      is discriminatory.
FAU - London, Leslie
AU  - London L
AD  - Centre for Occupational and Environmental Health Research, School of Public
      Health and Family Medicine, University of Cape Town, South Africa.
      leslie.london@uct.ac.za
FAU - Manjra, Shuaib
AU  - Manjra S
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Int J Occup Environ Health
JT  - International journal of occupational and environmental health
JID - 9505217
SB  - IM
MH  - *Attitude to Health
MH  - Cognition Disorders/complications
MH  - Communicable Diseases/complications
MH  - *Employment
MH  - HIV Infections/complications/*psychology/transmission
MH  - Humans
MH  - Military Personnel/*psychology
MH  - Physical Fitness
MH  - Prejudice
MH  - Risk Factors
EDAT- 2011/11/11 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/11/11 06:00
PHST- 2011/11/11 06:00 [entrez]
PHST- 2011/11/11 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 10.1179/107735211799041805 [doi]
PST - ppublish
SO  - Int J Occup Environ Health. 2011 Oct-Dec;17(4):352-60. doi:
      10.1179/107735211799041805.


PMID- 24466499
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 2157-7633 (Print)
VI  - 2
IP  - 2
DP  - 2011 Nov 11
TI  - Long-term Culture of Human SSEA-4 Positive Spermatogonial Stem Cells (SSCs).
LID - 2488 [pii]
AB  - Recently we and two other groups have shown that human spermatogonial stem cells 
      (SSCs) have the potential to become pluripotent in vitro in defined culture
      conditions and to differentiate into cells of the three embryonic germ layers.
      This discovery could open new avenues for autologous cell-based therapy in
      degenerative diseases, bypassing the ethical and immunological problems related
      to the human embryonic stem cells. In addition, human SSCs could be used to treat
      infertility in cancer survival children. However, in order to reprogram SSCs into
      pluripotency, or to preserve them for repopulation of infertile testes, the first
      and limiting step is to have access to a highly purified human SSC population
      that could be multiplied and efficiently cultured in vitro maintaining their
      molecular and cellular characteristics. Although various studies have attempted
      to identify molecular markers of human SSCs, to date there is still limited
      information related to the specific markers that could be used for their
      isolation and optimized purification that allows long-term in vitro culture of
      isolated human SSCs. Here using SSEA-4 as an optimal marker for isolation of a
      subpopulation of SSCs, we show that SSEA-4 positive cells express the highest
      level of SSC genes compared to other subpopulations isolated with different
      markers, and can be maintained in culture for over 14 passages which we were
      unable to obtain with other SSCs markers including GPR125 and ITGA6. In addition,
      we have established a new technology for cell sorting and long-term culture of
      human SSC-SSEA-4 positive cells that maximizes the purity and viability of the
      sorted cells. Our findings are crucial and could be used for the most efficient
      isolation, purification and long-term culture of SSCs for clinical applications
      in regenerative medicine, or for preparation of human SSCs for autologous
      treatment of infertility in cancer survival children.
FAU - Kokkinaki, Maria
AU  - Kokkinaki M
AD  - Georgetown University School of Medicine, Department of Biochemistry and
      Molecular & Cellular Biology ; Lombardi Comprehensive Cancer Center, Georgetown
      University School of Medicine.
FAU - Djourabtchi, Ardalan
AU  - Djourabtchi A
AD  - Georgetown University School of Medicine, Department of Biochemistry and
      Molecular & Cellular Biology.
FAU - Golestaneh, Nady
AU  - Golestaneh N
AD  - Georgetown University School of Medicine, Department of Biochemistry and
      Molecular & Cellular Biology ; Lombardi Comprehensive Cancer Center, Georgetown
      University School of Medicine.
LA  - eng
GR  - R21 EY019383/EY/NEI NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - J Stem Cell Res Ther
JT  - Journal of stem cell research & therapy
JID - 101586297
PMC - PMC3898576
MID - NIHMS482401
OTO - NOTNLM
OT  - Cell-based therapy
OT  - Human spermatogonial stem cells
OT  - Infertility
OT  - Long-term culture
OT  - Stem cell isolation
EDAT- 2011/11/11 00:00
MHDA- 2011/11/11 00:01
CRDT- 2014/01/28 06:00
PHST- 2014/01/28 06:00 [entrez]
PHST- 2011/11/11 00:00 [pubmed]
PHST- 2011/11/11 00:01 [medline]
AID - 10.4172/2157-7633.S2-003 [doi]
PST - ppublish
SO  - J Stem Cell Res Ther. 2011 Nov 11;2(2). doi: 10.4172/2157-7633.S2-003.


PMID- 22068631
OWN - NLM
STAT- MEDLINE
DCOM- 20120727
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 17
IP  - 4
DP  - 2011 Dec
TI  - Adding to the mix: integrating ELSI into a National Nanoscale Science and
      Technology Center.
PG  - 743-60
LID - 10.1007/s11948-011-9311-1 [doi]
AB  - This paper describes issues associated with integrating the study of Ethical,
      Legal and Social Issues (ELSI) into ongoing scientific and technical research and
      describes an approach adopted by the authors for their own work with the center
      for nanophase materials sciences (CNMS) at the Oak Ridge national laboratory
      (ORNL). Four key questions are considered: (a) What is ELSI and how should it
      identify and address topics of interest for the CNMS? (b) What advantages accrue 
      to incorporating ELSI into the CNMS? (c) How should the integration of ELSI into 
      the CNMS take place? (d) How should one judge the effectiveness of the activity? 
      We conclude that ELSI research is not a monolithic body of knowledge, but should 
      be adapted to the question at hand. Our approach focuses on junctures in the R&D 
      continuum at which key decisions occur, avoids topics of a purely ethical nature 
      or advocacy, and seeks to gather data in ways that permit testing the validity of
      generalization. Integrating ELSI into the CNMS allows dealing with topics firmly 
      grounded in science, offers concrete examples of potential downstream
      applications and provides access to the scientists using the CNMS and their
      insights and observations. As well, integration provides the opportunity for R&D 
      managers to benefit from ELSI insights and the potential to modify R&D agendas.
      Successful integration is dependent on the particular ELSI question set that
      drives the project. In this case questions sought to identify key choices,
      information of value to scientists, institutional attributes, key attributes of
      the CNMS culture, and alternatives for communicating results. The opportunity to 
      consult with scientists on ELSI implications is offered, but not promoted.
      Finally, ELSI effectiveness is judged by observing the use to which research
      products are put within the CNMS, ORNL, and the community of external scholars.
FAU - Bjornstad, David J
AU  - Bjornstad DJ
AD  - Society-Technology Interactions Group Leader, Environmental Sciences Division,
      Oak Ridge National Laboratory, P.O. Box 2008 MS 6038, Oak Ridge, TN 37831-6036,
      USA. bjornstaddj@ornl.gov
FAU - Wolfe, Amy K
AU  - Wolfe AK
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20111109
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
CIN - Sci Eng Ethics. 2011 Dec;17(4):761-7. PMID: 22090342
MH  - Communication
MH  - Decision Making
MH  - *Ethics, Research
MH  - Humans
MH  - Information Dissemination
MH  - Laboratories
MH  - Nanotechnology/*ethics/legislation & jurisprudence
MH  - *Public Policy
MH  - Science
MH  - *Social Values
MH  - Tennessee
EDAT- 2011/11/10 06:00
MHDA- 2012/07/28 06:00
CRDT- 2011/11/10 06:00
PHST- 2008/02/08 00:00 [received]
PHST- 2011/08/17 00:00 [accepted]
PHST- 2011/11/10 06:00 [entrez]
PHST- 2011/11/10 06:00 [pubmed]
PHST- 2012/07/28 06:00 [medline]
AID - 10.1007/s11948-011-9311-1 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2011 Dec;17(4):743-60. doi: 10.1007/s11948-011-9311-1. Epub 2011 
      Nov 9.


PMID- 22067934
OWN - NLM
STAT- MEDLINE
DCOM- 20120125
LR  - 20161125
IS  - 0966-0461 (Print)
IS  - 0966-0461 (Linking)
VI  - 20
IP  - 20
DP  - 2011 Nov 10-23
TI  - Clinical evaluation of Allevyn Gentle Border Lite within one health trust.
PG  - S36, S38-42
AB  - This article outlines the financial cost of wound care and the importance of
      appropriate dressings to achieve both clinical and economic outcomes. A clinical 
      evaluation of Allevyn Gentle Border Lite including 50 patients within one health 
      trust was undertaken to assess ease of application, wear time, ease of removal,
      durability and patient comfort. An observation is made that wound care is complex
      and health professionals require a knowledge and understanding of the wound
      healing process, pain, dressing products, asepsis, microbiology, pharmacology,
      psychosocial factors, and ethics, and should possess good communication skills. A
      conclusion is made that the 50 patient evaluation demonstrates the flexibility of
      the Allevyn Gentle Border Lite, which allows for a secure fit, provides active
      fluid management in its control of exudates, may be applied to patients with
      fragile skin, thereby avoiding the need for secondary retention, and may be used 
      on difficult-to-dress areas.
FAU - Stephen-Haynes, Jackie
AU  - Stephen-Haynes J
AD  - Birmingham City University.
FAU - Greenwood, Michelle
AU  - Greenwood M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Nurs
JT  - British journal of nursing (Mark Allen Publishing)
JID - 9212059
MH  - Adult
MH  - Bandages/economics/*standards
MH  - Hospital Costs
MH  - Hospitals, Public/*standards
MH  - Humans
MH  - Nursing Audit
MH  - Patient Satisfaction
MH  - Skin Ulcer/economics/*therapy
MH  - *State Medicine
MH  - United Kingdom
MH  - Wounds and Injuries/economics/*therapy
EDAT- 2011/11/10 06:00
MHDA- 2012/01/26 06:00
CRDT- 2011/11/10 06:00
PHST- 2011/11/10 06:00 [entrez]
PHST- 2011/11/10 06:00 [pubmed]
PHST- 2012/01/26 06:00 [medline]
AID - 10.12968/bjon.2011.20.Sup12.S36 [doi]
PST - ppublish
SO  - Br J Nurs. 2011 Nov 10-23;20(20):S36, S38-42. doi:
      10.12968/bjon.2011.20.Sup12.S36.


PMID- 22067810
OWN - NLM
STAT- MEDLINE
DCOM- 20120507
LR  - 20181201
IS  - 1879-0518 (Electronic)
IS  - 0010-7824 (Linking)
VI  - 85
IP  - 2
DP  - 2012 Feb
TI  - Feticidal digoxin injection before dilation and evacuation abortion: evidence and
      ethics.
PG  - 140-3
LID - 10.1016/j.contraception.2011.04.001 [doi]
FAU - Grimes, David A
AU  - Grimes DA
AD  - Department of Obstetrics and Gynecology, UNC School of Medicine, Chapel Hill, NC 
      27599-7570, USA. dgrimes@fhi.org
FAU - Stuart, Gretchen S
AU  - Stuart GS
FAU - Raymond, Elizabeth G
AU  - Raymond EG
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20110526
PL  - United States
TA  - Contraception
JT  - Contraception
JID - 0234361
RN  - 0 (Anti-Arrhythmia Agents)
RN  - 73K4184T59 (Digoxin)
SB  - IM
CON - Contraception. 2012 Feb;85(2):144-9. PMID: 22067788
CON - Contraception. 2012 Feb;85(2):150-4. PMID: 22067811
MH  - Abortion, Induced/*adverse effects/*methods
MH  - Anti-Arrhythmia Agents/*pharmacology
MH  - Digoxin/*pharmacology
MH  - Female
MH  - Humans
MH  - Pregnancy
EDAT- 2011/11/10 06:00
MHDA- 2012/05/09 06:00
CRDT- 2011/11/10 06:00
PHST- 2011/03/22 00:00 [received]
PHST- 2011/04/07 00:00 [accepted]
PHST- 2011/11/10 06:00 [entrez]
PHST- 2011/11/10 06:00 [pubmed]
PHST- 2012/05/09 06:00 [medline]
AID - S0010-7824(11)00160-0 [pii]
AID - 10.1016/j.contraception.2011.04.001 [doi]
PST - ppublish
SO  - Contraception. 2012 Feb;85(2):140-3. doi: 10.1016/j.contraception.2011.04.001.
      Epub 2011 May 26.


PMID- 22067742
OWN - NLM
STAT- MEDLINE
DCOM- 20120412
LR  - 20191210
IS  - 1879-0089 (Electronic)
IS  - 0145-305X (Linking)
VI  - 36
IP  - 4
DP  - 2012 Apr
TI  - Health status, infection and disease in California sea lions (Zalophus
      californianus) studied using a canine microarray platform and machine-learning
      approaches.
PG  - 629-37
LID - 10.1016/j.dci.2011.10.011 [doi]
AB  - Conservation biologists face many challenges in assessing health, immune status
      and infectious diseases in protected species. These challenges include
      unpredictable sample populations, diverse genetic and environmental backgrounds
      of the animals, as well as the practical, legal and ethical issues involved in
      experimentation. The use of whole genome scale transcriptomics with animal
      samples obtained in a minimally invasive manner is an approach that shows promise
      for health assessment. In this study we assessed the utility of a microarray to
      identify changes in gene expression predictive of health status by interrogating 
      blood samples from California sea lions (Zalophus californianus) in
      rehabilitation. A custom microarray was developed from the commercially available
      dog microarray (Canis familiaris) by selecting probes that demonstrated reliable 
      cross-hybridization with RNA in sea lion blood. This custom microarray was used
      for the analysis of RNA from 73 sea lion blood samples, from animals with a broad
      spectrum of health changes. Both traditional classifying techniques and newer
      artificial neural network approaches correctly classified sea lions with respect 
      to health status, primarily distinguishing between leptospirosis infection and
      domoic acid exposure. Real time PCR validation for a small set of genes, followed
      by sequencing, showed good correlation with array results and high identity
      (96-98%) between the dog and sea lion sequences. This approach to health status
      classification shows promise for disease identification in a clinical setting,
      and assessment of health status of wildlife.
CI  - Published by Elsevier Ltd.
FAU - Mancia, Annalaura
AU  - Mancia A
AD  - Medical University of South Carolina, Marine Biomedicine and Environmental
      Sciences Center, Hollings Marine Laboratory, 331 Ft Johnson Rd., Charleston, SC
      29412, USA. annalaura.mancia@unife.i
FAU - Ryan, James C
AU  - Ryan JC
FAU - Chapman, Robert W
AU  - Chapman RW
FAU - Wu, Qingzhong
AU  - Wu Q
FAU - Warr, Gregory W
AU  - Warr GW
FAU - Gulland, Frances M D
AU  - Gulland FM
FAU - Van Dolah, Frances M
AU  - Van Dolah FM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20111031
PL  - United States
TA  - Dev Comp Immunol
JT  - Developmental and comparative immunology
JID - 7708205
SB  - IM
MH  - Animal Migration
MH  - Animals
MH  - Dogs/*genetics
MH  - Female
MH  - Gene Expression Profiling/*methods
MH  - Leptospirosis/blood/*veterinary
MH  - Leukocytes/metabolism
MH  - Male
MH  - Neural Networks, Computer
MH  - Oligonucleotide Array Sequence Analysis/*methods
MH  - Sea Lions/genetics/*physiology
EDAT- 2011/11/10 06:00
MHDA- 2012/04/13 06:00
CRDT- 2011/11/10 06:00
PHST- 2011/05/19 00:00 [received]
PHST- 2011/10/21 00:00 [revised]
PHST- 2011/10/22 00:00 [accepted]
PHST- 2011/11/10 06:00 [entrez]
PHST- 2011/11/10 06:00 [pubmed]
PHST- 2012/04/13 06:00 [medline]
AID - S0145-305X(11)00295-3 [pii]
AID - 10.1016/j.dci.2011.10.011 [doi]
PST - ppublish
SO  - Dev Comp Immunol. 2012 Apr;36(4):629-37. doi: 10.1016/j.dci.2011.10.011. Epub
      2011 Oct 31.


PMID- 22067676
OWN - NLM
STAT- MEDLINE
DCOM- 20160423
LR  - 20181201
IS  - 1357-6321 (Print)
IS  - 1357-6321 (Linking)
VI  - 17
IP  - 8
DP  - 2011 Aug
TI  - Advance directives: Portuguese palliative care professionals' views.
PG  - 373-80
AB  - Advance directives are a controversial subject in Portugal at present,
      particularly among health professionals. Although some health professionals
      consider them to be important tools that are helpful in making proper decisions
      and promoting patient autonomy, others think that they may interfere with the
      human and relational dimension of care. It is therefore timely to investigate
      health professionals' views of advance directives in more detail. This study
      aimed to identify and reflect on Portuguese palliative care professionals'
      perspectives of advanced directives and their relevance to end-of-life decision
      making. A qualitative exploratory methodology was adopted in which interviews
      were conducted with two physicians, six nurses, two psychologists, and one social
      worker from four palliative care teams based across Portugal. The findings
      emphasize the relevance of advance directives to ethical decision-making
      processes in palliative care. However, debates are needed regarding whether
      advance directives should be legally binding.
FAU - Pereira, Sandra M
AU  - Pereira SM
FAU - Fradique, Emilia
AU  - Fradique E
FAU - Fialho, Renata
AU  - Fialho R
FAU - Cerqueira, Manuela
AU  - Cerqueira M
FAU - Pereira, Aurora
AU  - Pereira A
FAU - Sampaio, Florbela
AU  - Sampaio F
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Palliat Nurs
JT  - International journal of palliative nursing
JID - 9506762
MH  - Advance Directives
MH  - *Attitude of Health Personnel
MH  - Decision Making
MH  - Health Personnel
MH  - Humans
MH  - *Palliative Care
EDAT- 2011/11/10 06:00
MHDA- 2016/04/24 06:00
CRDT- 2011/11/10 06:00
PHST- 2011/11/10 06:00 [entrez]
PHST- 2011/11/10 06:00 [pubmed]
PHST- 2016/04/24 06:00 [medline]
AID - 10.12968/ijpn.2011.17.8.373 [doi]
PST - ppublish
SO  - Int J Palliat Nurs. 2011 Aug;17(8):373-80. doi: 10.12968/ijpn.2011.17.8.373.


PMID- 22067643
OWN - NLM
STAT- MEDLINE
DCOM- 20120105
LR  - 20111109
IS  - 0966-0461 (Print)
IS  - 0966-0461 (Linking)
VI  - 20
IP  - 18
DP  - 2011 Oct 13-27
TI  - To pray or not to pray: a question of ethics.
PG  - 1198-200, 1202-4
AB  - There is a widespread belief that nurses have a duty to provide spiritual care.
      However, many feel there is still a need for debate surrounding the ethical use
      of prayer in both nursing research and practice. By using critical reflections
      and evidence-based literature, this paper develops a discourse on the ethics of
      prayer as a spiritual intervention in nursing and health care practice. Several
      key ethical issues are highlighted. In regards to research, lack of informed
      consent is a major concern in both research and nursing practice. Key ethical
      issues in practice include questions around intention and authority, e.g. despite
      the religious beliefs of the nurse, intentions to proselytize must be avoided to 
      protect patient autonomy and avoid abuse of the nurse's authority. Furthermore,
      prayer has unknown side effects and implications. This paper concludes that, in
      practice, nurses must reconcile their personal, spiritual beliefs with their
      professional duties, and while this may be a delicate balance, it is not yet
      appropriate to encourage or dissuade a patient from their beliefs until
      appropriate research evidence is produced.
FAU - French, Charlotte
AU  - French C
AD  - Rotherham General Hospital, UK.
FAU - Narayanasamy, Aru
AU  - Narayanasamy A
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Nurs
JT  - British journal of nursing (Mark Allen Publishing)
JID - 9212059
MH  - *Ethics, Nursing
MH  - Health Services Research/ethics
MH  - Humans
MH  - Informed Consent/ethics
MH  - Nurse-Patient Relations/ethics
MH  - Nursing Care/*ethics
MH  - Nursing Research
MH  - *Religion
MH  - Spirituality
EDAT- 2011/11/10 06:00
MHDA- 2012/01/06 06:00
CRDT- 2011/11/10 06:00
PHST- 2011/11/10 06:00 [entrez]
PHST- 2011/11/10 06:00 [pubmed]
PHST- 2012/01/06 06:00 [medline]
AID - 10.12968/bjon.2011.20.18.1198 [doi]
PST - ppublish
SO  - Br J Nurs. 2011 Oct 13-27;20(18):1198-200, 1202-4. doi:
      10.12968/bjon.2011.20.18.1198.


PMID- 22065887
OWN - NLM
STAT- MEDLINE
DCOM- 20120224
LR  - 20220310
IS  - 1527-330X (Electronic)
IS  - 1090-820X (Linking)
VI  - 31
IP  - 8
DP  - 2011 Nov
TI  - Plastic surgery marketing in a generation of "tweeting".
PG  - 972-6
LID - 10.1177/1090820X11423764 [doi]
AB  - BACKGROUND: "Social media" describes interactive communication through Web-based 
      technologies. It has become an everyday part of modern life, yet there is a lack 
      of research regarding its impact on plastic surgery practice. OBJECTIVES: The
      authors evaluate and compare the prevalence of classic marketing methods and
      social media in plastic surgery. METHODS: The Web sites of aesthetic surgeons
      from seven US cities were compared and evaluated for the existence of Facebook,
      Twitter, or MySpace links and promotions. To find the sites, the authors
      conducted a Google search for the phrase "plastic surgery" with the name of each 
      city to be studied: Beverly Hills, California; Dallas, Texas; Houston, Texas; Las
      Vegas, Nevada; Miami, Florida; New York City, New York; and San Francisco,
      California. The trends of social networking memberships were also studied in each
      of these cities. RESULTS: In comparison to aesthetic surgeons practicing in other
      cities, those in Miami, Florida, favored social media the most, with 50%
      promoting a Facebook page and 46% promoting Twitter. Fifty-six percent of New
      York City aesthetic surgeons promoted their featured articles in magazines and
      newspapers, whereas 54% of Beverly Hills aesthetic surgeons promoted their
      television appearances. An increase in the number of new Facebook memberships
      among cosmetic providers in the seven cities began in October 2008 and reached a 
      peak in October, November, and December 2009, with subsequent stabilization. The 
      increase in the number of new Twitter memberships began in July 2008 and remained
      at a steady rate of approximately 15 new memberships every three months.
      CONCLUSIONS: Social media may seem like a new and unique communication tool, but 
      it is important to preserve professionalism and apply traditional Web
      site-building ethics and principles to these sites. We can expect continued
      growth in plastic surgeons' utilization of these networks to enhance their
      practices and possibly to launch direct marketing campaigns.
FAU - Wong, Wendy W
AU  - Wong WW
AD  - Department of Plastic and Reconstructive Surgery, Loma Linda University, Loma
      Linda, California 92350, USA.
FAU - Gupta, Subhas C
AU  - Gupta SC
LA  - eng
PT  - Journal Article
PL  - England
TA  - Aesthet Surg J
JT  - Aesthetic surgery journal
JID - 9707469
SB  - IM
MH  - Blogging/ethics/*organization & administration/trends
MH  - Humans
MH  - Internet
MH  - Marketing of Health Services/ethics/organization & administration/trends
MH  - Physicians/ethics/organization & administration/trends
MH  - *Social Marketing
MH  - Social Media/ethics/organization & administration/trends
MH  - Surgery, Plastic/ethics/*organization & administration/trends
MH  - United States
EDAT- 2011/11/09 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/11/09 06:00
PHST- 2011/11/09 06:00 [entrez]
PHST- 2011/11/09 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - 31/8/972 [pii]
AID - 10.1177/1090820X11423764 [doi]
PST - ppublish
SO  - Aesthet Surg J. 2011 Nov;31(8):972-6. doi: 10.1177/1090820X11423764.


PMID- 22065686
OWN - NLM
STAT- MEDLINE
DCOM- 20120405
LR  - 20111108
IS  - 1527-1927 (Electronic)
IS  - 0361-6878 (Linking)
VI  - 36
IP  - 5
DP  - 2011 Oct
TI  - The ethics of the affordability of health insurance.
PG  - 815-27
LID - 10.1215/03616878-1407631 [doi]
AB  - In this essay we argue that the concept of affordable health insurance is rooted 
      in a social obligation to protect fair equality of opportunity. Specifically,
      health insurance plays a limited but significant role in protecting opportunity
      in two ways: it helps keep people functioning normally and it protects their
      financial security. Together these benefits enable household members to exercise 
      reasonable choices about their plans of life. To achieve truly affordable
      coverage, society must be able to contain the overall cost of health care, and
      health insurance must be progressively financed, meaning that those who are best 
      able to pay for coverage should pay the largest share. While the recently passed 
      Patient Protection and Affordable Care Act (ACA) falls short on both of these
      counts, we argue that it makes important contributions toward household
      affordability through the use of subsidies and regulations. The main shortcoming 
      of the ACA is an insufficient protection against burdensome cost sharing, which
      we illustrate using several hypothetical scenarios. We conclude with
      recommendations about how to make opportunity-enhancing expansions to the current
      coverage subsidies.
FAU - Saloner, Brendan
AU  - Saloner B
AD  - Harvard University, USA.
FAU - Daniels, Norman
AU  - Daniels N
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Health Polit Policy Law
JT  - Journal of health politics, policy and law
JID - 7609331
SB  - IM
MH  - Health Services Needs and Demand
MH  - Humans
MH  - Insurance Coverage/*economics
MH  - Insurance, Health/*economics
MH  - Patient Protection and Affordable Care Act/economics
MH  - Public Policy
MH  - Social Responsibility
MH  - Taxes
MH  - United States
EDAT- 2011/11/09 06:00
MHDA- 2012/04/06 06:00
CRDT- 2011/11/09 06:00
PHST- 2011/11/09 06:00 [entrez]
PHST- 2011/11/09 06:00 [pubmed]
PHST- 2012/04/06 06:00 [medline]
AID - 36/5/815 [pii]
AID - 10.1215/03616878-1407631 [doi]
PST - ppublish
SO  - J Health Polit Policy Law. 2011 Oct;36(5):815-27. doi: 10.1215/03616878-1407631.


PMID- 22065385
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20111108
IS  - 1722-6899 (Print)
IS  - 1722-6899 (Linking)
VI  - 9
IP  - 2
DP  - 2011 May-Aug
TI  - Trends in biomedical engineering: focus on Regenerative Medicine.
PG  - 73-86
LID - 10.5301/JABB.2011.8562 [doi]
AB  - Regenerative medicine is a critical frontier in biomedical and clinical research.
      The major progresses in the last few years were driven by a strong clinical need 
      which could benefit from regenerative medicine outcomes for the treatment of a
      large number of conditions including birth defects, degenerative and neoplastic
      diseases, and traumatic injuries. Regenerative medicine applies the principles of
      engineering and life sciences to enhance the comprehension of the fundamental
      biological mechanisms underlying the structure-function relationships in
      physiologic and pathologic tissues and to accomplish alternative strategies for
      developing in vitro biological substitutes which are able to restore, maintain,
      or improve tissue, and organ function. This paper reviews selected approaches
      currently being investigated at Politecnico di Milano in the field of
      regenerative medicine. Specific tissue-oriented topics are divided in three
      sections according to each developmental stage: in vitro study, pre-clinical
      study, and clinical application. In vitro studies investigate the basic phenomena
      related to gene delivery, stem cell behavior, tissue regeneration, and to explore
      dynamic culture potentiality in different applications: cardiac and skeletal
      muscle, cartilage, hematopoietic system, peripheral nerve, and gene delivery.
      Specific fields of regenerative medicine, i.e., bone, blood vessels, and
      ligaments engineering have already reached the preclinical stage providing
      promising insights for further research towards clinical applications. The
      translation of the results obtained during in vitro and preclinical steps into
      clinical organ replacement is a very challenging issue, which can offer a valid
      alternative to fight morbidity, organ shortage, and ethical-social problems
      associated with allotransplantation as shown in the clinical case reported in
      this review.
FAU - Asnaghi, M Adelaide
AU  - Asnaghi MA
AD  - Department of Bioengineering, Politecnico di Milano, Milano, Italy.
FAU - Candiani, Gabriele
AU  - Candiani G
FAU - Fare, Silvia
AU  - Fare S
FAU - Fiore, Gianfranco B
AU  - Fiore GB
FAU - Petrini, Paola
AU  - Petrini P
FAU - Raimondi, Manuela T
AU  - Raimondi MT
FAU - Soncini, Monica
AU  - Soncini M
FAU - Mantero, Sara
AU  - Mantero S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Italy
TA  - J Appl Biomater Biomech
JT  - Journal of applied biomaterials & biomechanics : JABB
JID - 101180437
SB  - IM
MH  - Biomedical Engineering/*methods/*trends
MH  - Gene Transfer Techniques/instrumentation/trends
MH  - Regeneration
MH  - *Regenerative Medicine/instrumentation/methods/trends
MH  - Stem Cells
EDAT- 2011/11/09 06:00
MHDA- 2013/03/13 06:00
CRDT- 2011/11/09 06:00
PHST- 2011/04/21 00:00 [accepted]
PHST- 2011/11/09 06:00 [entrez]
PHST- 2011/11/09 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
AID - 4CC2646A-00C1-45AB-9047-105FD2126E7D [pii]
AID - 10.5301/JABB.2011.8562 [doi]
PST - ppublish
SO  - J Appl Biomater Biomech. 2011 May-Aug;9(2):73-86. doi: 10.5301/JABB.2011.8562.


PMID- 22065312
OWN - NLM
STAT- MEDLINE
DCOM- 20120224
LR  - 20111108
IS  - 1439-3964 (Electronic)
IS  - 0172-4622 (Linking)
VI  - 32
IP  - 11
DP  - 2011 Nov
TI  - Update--Ethical standards in sport and exercise science research.
PG  - 819-21
LID - 10.1055/s-0031-1287829 [doi]
FAU - Harriss, D J
AU  - Harriss DJ
FAU - Atkinson, G
AU  - Atkinson G
LA  - eng
PT  - Editorial
DEP - 20111107
PL  - Germany
TA  - Int J Sports Med
JT  - International journal of sports medicine
JID - 8008349
SB  - IM
MH  - Animal Welfare/ethics
MH  - Animals
MH  - Biomedical Research/*ethics
MH  - Editorial Policies
MH  - *Exercise
MH  - Human Experimentation/ethics
MH  - Humans
MH  - Periodicals as Topic/standards
MH  - Research Design
MH  - *Sports Medicine
EDAT- 2011/11/09 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/11/09 06:00
PHST- 2011/11/09 06:00 [entrez]
PHST- 2011/11/09 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - 10.1055/s-0031-1287829 [doi]
PST - ppublish
SO  - Int J Sports Med. 2011 Nov;32(11):819-21. doi: 10.1055/s-0031-1287829. Epub 2011 
      Nov 7.


PMID- 22065003
OWN - NLM
STAT- MEDLINE
DCOM- 20120313
LR  - 20211203
IS  - 0304-4602 (Print)
IS  - 0304-4602 (Linking)
VI  - 40
IP  - 8
DP  - 2011 Aug
TI  - Challenges and pitfalls in the introduction of pharmacogenetics for cancer.
PG  - 369-74
AB  - There have been several success stories in the field of pharmacogenetics in
      recent years, including the analysis of HER2 amplification for trastuzumab
      selection in breast cancer and VKORC1 genotyping for warfarin dosing in
      thrombosis. Encouraging results from these studies suggest that genetic factors
      may indeed be important determinants of drug response and toxicity for at least
      some drugs. However, to apply pharmacogenetics appropriately, a thorough
      understanding of the scope and limitations of this field is required. The
      challenges include an appreciation of biological variability, logistical issues
      pertaining to the proper management of information, the need for robust methods
      and adequate sample quality with well-designed workflows. At the same time, the
      economics of pharmacogenetic testing from the perspective of clinicians,
      patients, governments, insurance companies and pharmaceutical companies will play
      an important role in determining its future use. Ethical considerations such as
      informed consent and patient privacy, as well as the role of regulatory bodies in
      addressing these issues, must be fully understood. Only once these issues are
      properly dealt with can the full benefits of pharmacogenetics begin to be
      realised.
FAU - Loh, Marie
AU  - Loh M
AD  - Cancer Science Institute of Singapore, National University of Singapore,
      Singapore.
FAU - Soong, Richie
AU  - Soong R
LA  - eng
PT  - Lecture
PL  - Singapore
TA  - Ann Acad Med Singap
JT  - Annals of the Academy of Medicine, Singapore
JID - 7503289
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Antineoplastic Agents/*pharmacology
MH  - Genetic Privacy/*ethics
MH  - Humans
MH  - *Informed Consent
MH  - Neoplasms/*drug therapy
MH  - Pharmacogenetics/*ethics/methods
MH  - Translational Research, Biomedical/*methods
EDAT- 2011/11/09 06:00
MHDA- 2012/03/14 06:00
CRDT- 2011/11/09 06:00
PHST- 2011/11/09 06:00 [entrez]
PHST- 2011/11/09 06:00 [pubmed]
PHST- 2012/03/14 06:00 [medline]
PST - ppublish
SO  - Ann Acad Med Singap. 2011 Aug;40(8):369-74.


PMID- 22064988
OWN - NLM
STAT- MEDLINE
DCOM- 20120222
LR  - 20220330
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 52
IP  - 13
DP  - 2011 Dec 20
TI  - Molecular characterization of explant cultured human oral mucosal epithelial
      cells.
PG  - 9548-54
LID - 10.1167/iovs.11-7946 [doi]
AB  - PURPOSE: To culture and characterize oral mucosal epithelial cells (OMEC) grown
      on de-epithelialized human amniotic membrane (HAM) to explore their suitability
      as autografts in patients with bilateral ocular surface disease (OSD) and limbal 
      stem cell deficiency. METHODS: Oral biopsy samples were obtained from 20 patients
      undergoing oral reconstructive surgery, with informed consent and Institutional
      Ethics Committee approval. Morphologic studies, transmission electron microscopy 
      (TEM), reverse transcriptase (RT) PCR and immunocytochemistry were used to
      characterize the OMEC. RESULTS: Morphologic studies and TEM revealed a confluent 
      sheet of proliferating, stratified oral epithelial cells connected to each other 
      by desmosomes, containing intracellular cytokeratins and abundant mucin granules.
      These characteristics were further corroborated and elucidated by RT-PCR and
      immunocytochemistry. The presence of markers of differentiated, stratified
      epithelial cells (cytokeratin K3, K4, K13, and connexin 43), progenitor stem cell
      cell markers (p63, p75, beta1-integrin/CD29, and ABCG2), and a variety of
      predominantly membrane-bound and a few gel-forming mucins (MUC 1, 5B, 6, 13, 15, 
      and 16) was established. CONCLUSIONS: Cultured OMEC have the potential to act as 
      autografts for ocular surface reconstruction in patients with bilateral ocular
      surface disease and can prove to be particularly beneficial to ameliorate the
      mucin deficiency state in dry eye associated with OSD.
FAU - Sen, Sudip
AU  - Sen S
AD  - Department of Ophthalmology, All India Institute of Medical Sciences, New Delhi, 
      India.
FAU - Sharma, Shweta
AU  - Sharma S
FAU - Gupta, Anand
AU  - Gupta A
FAU - Gupta, Noopur
AU  - Gupta N
FAU - Singh, Himi
AU  - Singh H
FAU - Roychoudhury, Ajoy
AU  - Roychoudhury A
FAU - Mohanty, Sujata
AU  - Mohanty S
FAU - Sen, Seema
AU  - Sen S
FAU - Nag, Tapas C
AU  - Nag TC
FAU - Tandon, Radhika
AU  - Tandon R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111220
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
RN  - 0 (Biomarkers)
SB  - IM
MH  - Amnion
MH  - Biomarkers/metabolism
MH  - Cell Differentiation
MH  - Cell Proliferation
MH  - Cells, Cultured
MH  - Coculture Techniques
MH  - Corneal Diseases/pathology/surgery
MH  - Epithelial Cells/*cytology/metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Limbus Corneae/pathology
MH  - Microscopy, Electron, Transmission
MH  - Mouth Mucosa/*cytology/metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Stem Cells/pathology
MH  - Transplantation, Autologous
EDAT- 2011/11/09 06:00
MHDA- 2012/02/23 06:00
CRDT- 2011/11/09 06:00
PHST- 2011/11/09 06:00 [entrez]
PHST- 2011/11/09 06:00 [pubmed]
PHST- 2012/02/23 06:00 [medline]
AID - iovs.11-7946 [pii]
AID - 10.1167/iovs.11-7946 [doi]
PST - epublish
SO  - Invest Ophthalmol Vis Sci. 2011 Dec 20;52(13):9548-54. doi: 10.1167/iovs.11-7946.


PMID- 22060053
OWN - NLM
STAT- MEDLINE
DCOM- 20120927
LR  - 20120514
IS  - 1365-2362 (Electronic)
IS  - 0014-2972 (Linking)
VI  - 42
IP  - 6
DP  - 2012 Jun
TI  - Renal differentiation of amniotic fluid stem cells: perspectives for clinical
      application and for studies on specific human genetic diseases.
PG  - 677-84
LID - 10.1111/j.1365-2362.2011.02622.x [doi]
AB  - BACKGROUND: Owing to growing rates of diabetes, hypertension and the ageing
      population, the prevalence of end-stage renal disease, developed from earlier
      stages of chronic kidney disease, and of acute renal failure is dramatically
      increasing. Dialysis and preferable renal transplantation are widely applied
      therapies for this incurable condition. However these options are limited because
      of morbidity, shortage of compatible organs and costs. Therefore, stem cell-based
      approaches are becoming increasingly accepted as an alternative therapeutic
      strategy. DESIGN: This review summarizes the current findings on the nephrogenic 
      potential of amniotic fluid stem (AFS) cells and their putative implications for 
      clinical applications and for studies on specific human genetic diseases.
      RESULTS: Since their discovery in 2003, AFS cells have been shown to be
      pluripotent with the potential to form embryoid bodies. Compared to adult stem
      cells, induced pluripotent stem cells or embryonic stem cells, AFS cells harbour 
      a variety of advantages, such as their high differentiation and proliferative
      potential, no need for ectopic induction of pluripotency and no somatic mutations
      and epigenetic memory of source cells, and no tumourigenic potential and
      associated ethical controversies, respectively. CONCLUSIONS: Recently, the
      results of different independent studies provided evidence that AFS cells could
      indeed be a powerful tool for renal regenerative medicine.
CI  - (c) 2011 The Authors. European Journal of Clinical Investigation (c) 2011
      Stichting European Society for Clinical Investigation Journal Foundation.
FAU - Rosner, Margit
AU  - Rosner M
AD  - Medical Genetics, Medical University of Vienna, Vienna, Austria.
FAU - Schipany, Katharina
AU  - Schipany K
FAU - Gundacker, Claudia
AU  - Gundacker C
FAU - Shanmugasundaram, Bharanidharan
AU  - Shanmugasundaram B
FAU - Li, Kongzhao
AU  - Li K
FAU - Fuchs, Christiane
AU  - Fuchs C
FAU - Lubec, Gert
AU  - Lubec G
FAU - Hengstschlager, Markus
AU  - Hengstschlager M
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111108
PL  - England
TA  - Eur J Clin Invest
JT  - European journal of clinical investigation
JID - 0245331
SB  - IM
MH  - Adult Stem Cells/*cytology/metabolism
MH  - Amniotic Fluid/*cytology/metabolism
MH  - Cell Differentiation/*physiology
MH  - Cell Transplantation/methods
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Kidney/metabolism/physiology
MH  - Kidney Failure, Chronic/*metabolism
MH  - Pluripotent Stem Cells/*cytology/metabolism
MH  - Regenerative Medicine/*methods
EDAT- 2011/11/09 06:00
MHDA- 2012/09/28 06:00
CRDT- 2011/11/09 06:00
PHST- 2011/11/09 06:00 [entrez]
PHST- 2011/11/09 06:00 [pubmed]
PHST- 2012/09/28 06:00 [medline]
AID - 10.1111/j.1365-2362.2011.02622.x [doi]
PST - ppublish
SO  - Eur J Clin Invest. 2012 Jun;42(6):677-84. doi: 10.1111/j.1365-2362.2011.02622.x. 
      Epub 2011 Nov 8.


PMID- 22060010
OWN - NLM
STAT- MEDLINE
DCOM- 20121101
LR  - 20120720
IS  - 1945-1474 (Electronic)
IS  - 1062-2551 (Linking)
VI  - 34
IP  - 4
DP  - 2012 Jul-Aug
TI  - Variation in local institutional review board evaluations of a multicenter
      patient safety study.
PG  - 33-9
LID - 10.1111/j.1945-1474.2011.00150.x [doi]
AB  - Several highly visible quality improvement (QI) projects led to controversy over 
      their ethical oversight, attracting attention from institutional review boards
      (IRBs) and the Office for Human Research Protection. While QI research has
      increased dramatically, there is limited empirical evidence regarding how
      multiple IRBs review the same study. This paper describes the variations in local
      IRB reviews for the same a multicenter QI study. The study, entitled "Locating
      Errors through Networked Surveillance", used multiple data collection methods to 
      identify patient safety risks in cardiovascular operating room services. This
      study involved 2-day site visits to 5 hospitals by the research team to observe
      cardiac surgery procedures and interview staff regarding clinical practice and
      hazards. Surveys were self-administered. The IRB process varied widely across the
      5 hospitals. Reviews ranged from full committee review and approval with verbal
      consent required from patients and operating room staff, to an IRB determining
      the study exempt from review and participant consent. The time to IRB approval
      ranged from 6 weeks to 6 months. This variation suggests there is wide
      interpretation of the Federal regulations put in place to guide IRBs. The
      adoption of uniformity would not only reduce inefficiencies but also attenuate
      the perceived arbitrary nature of current IRB review processes that often
      inappropriately influence hypothesis-generation and study design.
CI  - (c) 2011 National Association for Healthcare Quality.
FAU - Thompson, David A
AU  - Thompson DA
AD  - Departments of Anesthesiology and Critical Care Medicine, Johns Hopkins
      University School of Medicine, School of Nursing Division of Acute and Chronic
      Care, Baltimore, MD, USA. dthomps1@jhmi.edu
FAU - Kass, Nancy
AU  - Kass N
FAU - Holzmueller, Christine
AU  - Holzmueller C
FAU - Marsteller, Jill A
AU  - Marsteller JA
FAU - Martinez, Elizabeth A
AU  - Martinez EA
FAU - Gurses, Ayse P
AU  - Gurses AP
FAU - Kanchuger, Marc
AU  - Kanchuger M
FAU - Schwann, Nanette
AU  - Schwann N
FAU - Gibson, Charles S
AU  - Gibson CS
FAU - Bauer, Laura
AU  - Bauer L
FAU - Pronovost, Peter J
AU  - Pronovost PJ
LA  - eng
GR  - K01HS018762/HS/AHRQ HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20110525
PL  - United States
TA  - J Healthc Qual
JT  - Journal for healthcare quality : official publication of the National Association
      for Healthcare Quality
JID - 9202994
MH  - Cardiac Surgical Procedures
MH  - Ethics Committees, Research/*standards
MH  - *Facility Regulation and Control
MH  - Humans
MH  - Multicenter Studies as Topic
MH  - Operating Rooms
MH  - *Patient Safety
MH  - Prospective Studies
MH  - United States
EDAT- 2011/11/09 06:00
MHDA- 2012/11/02 06:00
CRDT- 2011/11/09 06:00
PHST- 2011/11/09 06:00 [entrez]
PHST- 2011/11/09 06:00 [pubmed]
PHST- 2012/11/02 06:00 [medline]
AID - 10.1111/j.1945-1474.2011.00150.x [doi]
PST - ppublish
SO  - J Healthc Qual. 2012 Jul-Aug;34(4):33-9. doi: 10.1111/j.1945-1474.2011.00150.x.
      Epub 2011 May 25.


PMID- 22059369
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20111108
IS  - 0019-1442 (Print)
IS  - 0019-1442 (Linking)
VI  - 64
IP  - 9-10
DP  - 2011 Sep 30
TI  - [Critical analysis of types and objectives of phamacological trials].
PG  - 325-7
AB  - Antiepileptic drug randomized controlled trial (RCT) design has been criticized
      in the near past. Designs emphasize conventions and regulations more than
      clinical aspects. In the new study that scrutinized RCT patient recruitment has
      also raised important ethical issues. The time has come when changes in RCT
      design seem imperative.
FAU - Juhos, Vera
AU  - Juhos V
AD  - EpiHope Kft., Budapest. vera.juhos@gmail.com
LA  - hun
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - A gyogyszervizsgalatok tipusainak es celjainak kritikai elemzese.
PL  - Hungary
TA  - Ideggyogy Sz
JT  - Ideggyogyaszati szemle
JID - 17510500R
RN  - 0 (Anticonvulsants)
SB  - IM
MH  - Anticonvulsants/*therapeutic use
MH  - Double-Blind Method
MH  - Evidence-Based Medicine
MH  - Humans
MH  - Patient Selection/*ethics
MH  - Randomized Controlled Trials as Topic/*ethics/*standards/trends
MH  - Research Design
EDAT- 2011/11/09 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/11/09 06:00
PHST- 2011/11/09 06:00 [entrez]
PHST- 2011/11/09 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PST - ppublish
SO  - Ideggyogy Sz. 2011 Sep 30;64(9-10):325-7.


PMID- 22045865
OWN - NLM
STAT- MEDLINE
DCOM- 20120105
LR  - 20111102
IS  - 1098-4275 (Electronic)
IS  - 0031-4005 (Linking)
VI  - 128 Suppl 4
DP  - 2011 Nov
TI  - Concluding comments: maximizing good patient care and minimizing potential
      liability when considering complementary and alternative medicine.
PG  - S206-12
LID - 10.1542/peds.2010-2720K [doi]
AB  - Our goal for this supplemental issue of Pediatrics was to consider what
      practitioners, parents, patients, institutions, and policy-makers need to take
      into account to make good decisions about using complementary and alternative
      medicine (CAM) to treat children and to develop guidelines for appropriate use.
      We began by explaining underlying concepts and principles in ethical, legal, and 
      clinical reasoning and then used case scenarios to explore how they apply and
      identify gaps that remain in practice and policy. In this concluding article, we 
      review our major findings, summarize our recommendations, and suggest further
      research. We focus on several key areas: practitioner and patient/parent
      relationships; decision-making; dispute resolution; standards of practice;
      hospital/health facility policies; patient safety; education; and research.
      Ethical principles, standards, and rules applicable when making decisions about
      conventional care for children apply to decision-making about CAM as well. The
      same is true of legal reasoning. Although CAM use has seldom led to litigation,
      general legal principles relied on in cases involving conventional medical care
      provide the starting point for analysis. Similarly, with respect to clinical
      decision-making, clinicians are guided by clinical judgment and the best
      interests of their patient. Whether a therapy is CAM or conventional, clinicians 
      must weigh the relative risks and benefits of therapeutic options and take into
      account their patient's values, beliefs, and preferences. Consequently, many of
      our observations apply to conventional and CAM care and to both adult and
      pediatric patients.
FAU - Gilmour, Joan
AU  - Gilmour J
AD  - Osgoode Hall Law School, York University, Toronto, Ontario, Canada.
FAU - Harrison, Christine
AU  - Harrison C
FAU - Vohra, Sunita
AU  - Vohra S
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pediatrics
JT  - Pediatrics
JID - 0376422
SB  - IM
MH  - Adolescent
MH  - Canada
MH  - Child
MH  - Communication
MH  - *Complementary Therapies/education/ethics/legislation & jurisprudence/standards
MH  - Decision Making/ethics
MH  - Dissent and Disputes
MH  - Health Policy
MH  - Hospitals/ethics/standards
MH  - Humans
MH  - Informed Consent/ethics/legislation & jurisprudence
MH  - Interpersonal Relations
MH  - *Liability, Legal
MH  - Parents
MH  - Patient Safety
MH  - *Pediatrics/ethics/legislation & jurisprudence/standards
MH  - *Quality of Health Care
MH  - Referral and Consultation/ethics/legislation & jurisprudence
MH  - Standard of Care
MH  - United States
EDAT- 2011/11/09 06:00
MHDA- 2012/01/06 06:00
CRDT- 2011/11/03 06:00
PHST- 2011/11/03 06:00 [entrez]
PHST- 2011/11/09 06:00 [pubmed]
PHST- 2012/01/06 06:00 [medline]
AID - 128/Supplement_4/S206 [pii]
AID - 10.1542/peds.2010-2720K [doi]
PST - ppublish
SO  - Pediatrics. 2011 Nov;128 Suppl 4:S206-12. doi: 10.1542/peds.2010-2720K.


PMID- 22045862
OWN - NLM
STAT- MEDLINE
DCOM- 20120105
LR  - 20111102
IS  - 1098-4275 (Electronic)
IS  - 0031-4005 (Linking)
VI  - 128 Suppl 4
DP  - 2011 Nov
TI  - Informed consent: advising patients and parents about complementary and
      alternative medicine therapies.
PG  - S187-92
LID - 10.1542/peds.2010-2720H [doi]
AB  - Although research on complementary and alternative medicine (CAM) therapies is
      still limited, systematic reviews have revealed sufficient evidence to conclude
      that CAM can be effective for certain conditions. In this article we discuss
      clinicians' responsibilities to inform parents/patients about CAM alternatives
      and use the example of acupuncture for chemotherapy-induced nausea and vomiting. 
      Chemotherapy-induced nausea and vomiting remain significant adverse effects of
      cancer therapy, and some patients cannot find relief with standard therapies.
      When making decisions for a child with a life-threatening illness, parents must
      consider all reasonable options and decide what is in the child's best interests.
      A physician's failure to provide parents with relevant information regarding
      therapies with the prospect of therapeutic benefit impedes their ability to make 
      an informed decision. Physicians have the ethical duty of beneficence; they must 
      be aware of current research in pain and symptom management and other aspects of 
      care. A physician's duty of care does not necessarily include the obligation to
      provide information about therapies outside the range of conventional treatment
      or those not yet supported in the medical literature. However, as CAM therapies
      such as acupuncture become better studied and their safety and efficacy are
      established, the scope of disclosure required may expand to include them. The
      legal and ethical obligation to obtain informed consent to treatment requires
      disclosure and discussion of therapies when there is reliable evidence of
      potential therapeutic benefit. At the same time, the more limited state of
      knowledge regarding effects of a particular therapy in the pediatric population
      must be factored into decision-making when treating a child.
FAU - Gilmour, Joan
AU  - Gilmour J
AD  - Osgoode Hall Law School, York University, Toronto, Ontario, Canada.
FAU - Harrison, Christine
AU  - Harrison C
FAU - Asadi, Leyla
AU  - Asadi L
FAU - Cohen, Michael H
AU  - Cohen MH
FAU - Vohra, Sunita
AU  - Vohra S
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pediatrics
JT  - Pediatrics
JID - 0376422
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Acupuncture Therapy/ethics
MH  - Antineoplastic Agents/adverse effects
MH  - Canada
MH  - Child
MH  - *Complementary Therapies/ethics/legislation & jurisprudence
MH  - *Disclosure/ethics/legislation & jurisprudence
MH  - Ethics, Medical
MH  - Humans
MH  - *Informed Consent/ethics/legislation & jurisprudence
MH  - Liability, Legal
MH  - Male
MH  - Nausea/etiology/therapy
MH  - Parents
MH  - Physician-Patient Relations
MH  - Professional-Family Relations
MH  - United States
MH  - Vomiting/etiology/therapy
EDAT- 2011/11/09 06:00
MHDA- 2012/01/06 06:00
CRDT- 2011/11/03 06:00
PHST- 2011/11/03 06:00 [entrez]
PHST- 2011/11/09 06:00 [pubmed]
PHST- 2012/01/06 06:00 [medline]
AID - 128/Supplement_4/S187 [pii]
AID - 10.1542/peds.2010-2720H [doi]
PST - ppublish
SO  - Pediatrics. 2011 Nov;128 Suppl 4:S187-92. doi: 10.1542/peds.2010-2720H.


PMID- 22045859
OWN - NLM
STAT- MEDLINE
DCOM- 20120105
LR  - 20111102
IS  - 1098-4275 (Electronic)
IS  - 0031-4005 (Linking)
VI  - 128 Suppl 4
DP  - 2011 Nov
TI  - Childhood immunization: when physicians and parents disagree.
PG  - S167-74
LID - 10.1542/peds.2010-2720E [doi]
AB  - Persistent fears about the safety and efficacy of vaccines, and whether
      immunization programs are still needed, have led a significant minority of
      parents to refuse vaccination. Are parents within their rights when refusing to
      consent to vaccination? How ought physicians respond? Focusing on routine
      childhood immunization, we consider the ethical, legal, and clinical issues
      raised by 3 aspects of parental vaccine refusal: (1) physician counseling; (2)
      parental decision-making; and (3) continuing the physician-patient relationship
      despite disagreement. We also suggest initiatives that could increase confidence 
      in immunization programs.
FAU - Gilmour, Joan
AU  - Gilmour J
AD  - Osgoode Hall Law School, York University, Toronto, Ontario, Canada.
FAU - Harrison, Christine
AU  - Harrison C
FAU - Asadi, Leyla
AU  - Asadi L
FAU - Cohen, Michael H
AU  - Cohen MH
FAU - Vohra, Sunita
AU  - Vohra S
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pediatrics
JT  - Pediatrics
JID - 0376422
RN  - 0 (Measles-Mumps-Rubella Vaccine)
SB  - IM
MH  - Canada
MH  - Child
MH  - Child, Preschool
MH  - Communication
MH  - Complementary Therapies
MH  - Decision Making
MH  - Directive Counseling/ethics
MH  - *Dissent and Disputes
MH  - Ethics, Medical
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - *Immunization/ethics/legislation & jurisprudence
MH  - Infant
MH  - Informed Consent/ethics
MH  - Liability, Legal
MH  - Male
MH  - Measles-Mumps-Rubella Vaccine
MH  - *Parents
MH  - Professional-Family Relations/ethics
MH  - *Treatment Refusal/ethics
MH  - United States
EDAT- 2011/11/09 06:00
MHDA- 2012/01/06 06:00
CRDT- 2011/11/03 06:00
PHST- 2011/11/03 06:00 [entrez]
PHST- 2011/11/09 06:00 [pubmed]
PHST- 2012/01/06 06:00 [medline]
AID - 128/Supplement_4/S167 [pii]
AID - 10.1542/peds.2010-2720E [doi]
PST - ppublish
SO  - Pediatrics. 2011 Nov;128 Suppl 4:S167-74. doi: 10.1542/peds.2010-2720E.


PMID- 22045856
OWN - NLM
STAT- MEDLINE
DCOM- 20120105
LR  - 20111102
IS  - 1098-4275 (Electronic)
IS  - 0031-4005 (Linking)
VI  - 128 Suppl 4
DP  - 2011 Nov
TI  - Pediatric use of complementary and alternative medicine: legal, ethical, and
      clinical issues in decision-making.
PG  - S149-54
LID - 10.1542/peds.2010-2720B [doi]
AB  - In this article we introduce a series of 8 case scenarios and commentaries and
      explore the complex legal, ethical, and clinical concerns that arise when
      pediatric patients and their parents or health care providers use or are
      interested in using complementary and alternative medicine (CAM). People around
      the world rely on CAM, so similar issues face clinicians in many countries. In
      law, few cases have dealt with CAM use. The few that have apply the same general 
      legal principles used in cases that involved conventional care while taking into 
      account considerations unique to CAM. In ethics, as with conventional care, the
      issues surrounding pediatric CAM use usually involve questions about who the
      appropriate decision-makers are, on what ethical principles should clinical
      decision-making rely, and what obligations arise on the part of physicians and
      other health care providers. Clinical decision-making is made more complex by the
      relatively limited research on the efficacy and safety of CAM compared with
      conventional medicine, especially in children, which requires clinicians to make 
      decisions under conditions of uncertainty. The clinical scenarios presented focus
      on patients who represent a range of ages, clinical conditions, and settings.
      They act as anchors to explore particular CAM policy issues and illustrate the
      application of and shortcomings in existing guidance and intervention principles.
      Although the focus on a pediatric population adds another layer of complexity to 
      the analysis, many of the concepts, issues, principles, and recommendations also 
      apply to adults.
FAU - Gilmour, Joan
AU  - Gilmour J
AD  - Osgoode Hall Law School, York University, Toronto, Ontario, Canada.
FAU - Harrison, Christine
AU  - Harrison C
FAU - Cohen, Michael H
AU  - Cohen MH
FAU - Vohra, Sunita
AU  - Vohra S
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pediatrics
JT  - Pediatrics
JID - 0376422
SB  - IM
MH  - Canada
MH  - Child
MH  - *Complementary Therapies/ethics/legislation & jurisprudence
MH  - Decision Making
MH  - Ethics, Medical
MH  - Health Policy
MH  - Humans
MH  - Liability, Legal
MH  - *Pediatrics/ethics/legislation & jurisprudence
MH  - United States
EDAT- 2011/11/09 06:00
MHDA- 2012/01/06 06:00
CRDT- 2011/11/03 06:00
PHST- 2011/11/03 06:00 [entrez]
PHST- 2011/11/09 06:00 [pubmed]
PHST- 2012/01/06 06:00 [medline]
AID - 128/Supplement_4/S149 [pii]
AID - 10.1542/peds.2010-2720B [doi]
PST - ppublish
SO  - Pediatrics. 2011 Nov;128 Suppl 4:S149-54. doi: 10.1542/peds.2010-2720B.


PMID- 22059200
OWN - NLM
STAT- MEDLINE
DCOM- 20111216
LR  - 20220409
IS  - 1203-6765 (Print)
IS  - 1203-6765 (Linking)
VI  - 16
IP  - 5
DP  - 2011 Sep-Oct
TI  - Persistent pain in a community-based sample of children and adolescents.
PG  - 303-9
AB  - BACKGROUND: Very few studies have investigated the psychological factors
      associated with the pain experiences of children and adolescents in community
      samples. OBJECTIVES: To examine the lifetime prevalence of, and psychological
      variables associated with, persistent pain in a community sample of children and 
      adolescents, and to explore differences according to sex, age and pain history.
      METHODS: Participants completed the Childhood Anxiety Sensitivity Index (CASI),
      the Child Pain Anxiety Symptoms Scale (CPASS), the Multidimensional Anxiety Scale
      for Children-10 (MASC-10), the Pain Catastrophizing Scale for Children (PCS-C)
      and a pain history questionnaire that assessed chronicity and pain frequency.
      After research ethics board approval, informed consentassent was obtained from
      1022 individuals recruited to participate in a study conducted at the Ontario
      Science Centre (Toronto, Ontario). RESULTS: Of the 1006 participants (54% female,
      mean [+/- SD] age 11.6+/-2.7 years) who provided complete data, 27% reported
      having experienced pain that lasted for three months or longer. A 2x2x2 (pain
      history, age and sex) multivariate ANOVA was conducted, with the total scores on 
      the CASI, the CPASS, the MASC-10 and the PCS-C as dependent variables. Girls with
      a history of persistent pain expressed higher levels of anxiety sensitivity
      (P<0.001) and pain catastrophizing (P<0.001) than both girls without a pain
      history and boys regardless of pain history. This same pattern of results was
      found for anxiety and pain anxiety in the older, but not the younger, age group. 
      CONCLUSIONS: Boys and girls appear to differ in terms of how age and pain history
      relate to the expression of pain-related psychological variables. Given the
      prevalence of persistent pain found in the study, more research is needed
      regarding the developmental implications of persistent pain in childhood and
      adolescence.
FAU - Fuss, Samantha
AU  - Fuss S
AD  - Department of PSychology, York University, Toronto, Ontario, Canada.
FAU - Page, Gabrielle
AU  - Page G
FAU - Katz, Joel
AU  - Katz J
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pain Res Manag
JT  - Pain research & management
JID - 9612504
SB  - IM
MH  - Adolescent
MH  - Analysis of Variance
MH  - Anxiety/*etiology/psychology
MH  - Chi-Square Distribution
MH  - Child
MH  - Chronic Disease
MH  - Female
MH  - Humans
MH  - Male
MH  - Pain/*complications/epidemiology/*psychology
MH  - Pain Measurement
MH  - Psychiatric Status Rating Scales
MH  - Residence Characteristics
MH  - Sensitivity and Specificity
MH  - Sex Factors
MH  - Surveys and Questionnaires
PMC - PMC3206778
EDAT- 2011/11/08 06:00
MHDA- 2011/12/17 06:00
CRDT- 2011/11/08 06:00
PHST- 2011/11/08 06:00 [entrez]
PHST- 2011/11/08 06:00 [pubmed]
PHST- 2011/12/17 06:00 [medline]
AID - 10.1155/2011/534652 [doi]
PST - ppublish
SO  - Pain Res Manag. 2011 Sep-Oct;16(5):303-9. doi: 10.1155/2011/534652.


PMID- 22058400
OWN - NLM
STAT- MEDLINE
DCOM- 20111229
LR  - 20111107
IS  - 1930-7837 (Electronic)
IS  - 0022-0337 (Linking)
VI  - 75
IP  - 11
DP  - 2011 Nov
TI  - Creating an effective PBL case in oral and maxillofacial surgery at a Chinese
      dental school: a dental education primer.
PG  - 1496-501
AB  - Problem-based learning (PBL) is a widely accepted educational method centered on 
      the discussion and learning that emerge from a clinically based problem; however,
      little has been reported on the details of PBL case-writing in the dental
      education literature. This article outlines some principles of writing a PBL case
      as it is practiced at a Chinese dental school and presents, as an example, an
      actual case based on a clinical problem (ameloblastoma of the jaw) intended to
      provide a learning focus for predoctoral dental students. A good PBL case should 
      allow for progressive, interdependent actions to be taken in the evaluation and
      overall management of the patient in context and should trigger inquiry and
      discussion among students in both the basic sciences (anatomy, physiology,
      biochemistry, pharmacology, pathophysiology, etc.) and related clinical sciences.
      The epidemiological, sociological, and ethical considerations related to each
      problem should also be emphasized as an essential component of effective health
      care provision.
FAU - Zheng, Jia Wei
AU  - Zheng JW
AD  - Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, College of
      Stomatology, Shanghai Jiao Tong University School of Medicine, No. 639 Zhi Zao Ju
      Road, Shanghai, People's Republic of China.
FAU - Zhang, Shan Yong
AU  - Zhang SY
FAU - Yang, Chi
AU  - Yang C
FAU - Zhang, Zhi Yuan
AU  - Zhang ZY
FAU - Shen, Guo Fang
AU  - Shen GF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Dent Educ
JT  - Journal of dental education
JID - 8000150
SB  - IM
MH  - Ameloblastoma/diagnosis
MH  - China
MH  - *Curriculum
MH  - Dental Records
MH  - Diagnostic Tests, Routine
MH  - *Education, Dental
MH  - Goals
MH  - Humans
MH  - Logic
MH  - Mandibular Neoplasms/diagnosis
MH  - Medical History Taking
MH  - Patient Care Planning
MH  - Physical Examination
MH  - Problem-Based Learning/*methods
MH  - Program Development/*methods
MH  - Schools, Dental
MH  - Surgery, Oral/*education
MH  - Teaching/methods
MH  - Teaching Materials
MH  - Writing
EDAT- 2011/11/08 06:00
MHDA- 2011/12/30 06:00
CRDT- 2011/11/08 06:00
PHST- 2011/11/08 06:00 [entrez]
PHST- 2011/11/08 06:00 [pubmed]
PHST- 2011/12/30 06:00 [medline]
AID - 75/11/1496 [pii]
PST - ppublish
SO  - J Dent Educ. 2011 Nov;75(11):1496-501.


PMID- 22058238
OWN - NLM
STAT- MEDLINE
DCOM- 20120106
LR  - 20120510
IS  - 2042-7670 (Electronic)
IS  - 0042-4900 (Linking)
VI  - 169
IP  - 19
DP  - 2011 Nov 5
TI  - Veterinary ethics and the humane treatment of animals.
PG  - 483-4
LID - 10.1136/vr.d6873 [doi]
LA  - eng
PT  - News
PL  - England
TA  - Vet Rec
JT  - The Veterinary record
JID - 0031164
SB  - IM
MH  - Animal Welfare/*ethics
MH  - Animals
MH  - Congresses as Topic
MH  - Humans
MH  - Veterinary Medicine/*ethics
EDAT- 2011/11/08 06:00
MHDA- 2012/01/10 06:00
CRDT- 2011/11/08 06:00
PHST- 2011/11/08 06:00 [entrez]
PHST- 2011/11/08 06:00 [pubmed]
PHST- 2012/01/10 06:00 [medline]
AID - vr.d6873 [pii]
AID - 10.1136/vr.d6873 [doi]
PST - ppublish
SO  - Vet Rec. 2011 Nov 5;169(19):483-4. doi: 10.1136/vr.d6873.


PMID- 22057782
OWN - NLM
STAT- MEDLINE
DCOM- 20120727
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 17
IP  - 4
DP  - 2011 Dec
TI  - What happens in the lab does not stay in the lab [corrected]: Applying midstream 
      modulation to enhance critical reflection in the laboratory.
PG  - 769-88
LID - 10.1007/s11948-011-9317-8 [doi]
AB  - In response to widespread policy prescriptions for responsible innovation, social
      scientists and engineering ethicists, among others, have sought to engage natural
      scientists and engineers at the 'midstream': building interdisciplinary
      collaborations to integrate social and ethical considerations with research and
      development processes. Two 'laboratory engagement studies' have explored how
      applying the framework of midstream modulation could enhance the reflections of
      natural scientists on the socio-ethical context of their work. The results of
      these interdisciplinary collaborations confirm the utility of midstream
      modulation in encouraging both first- and second-order reflective learning. The
      potential for second-order reflective learning, in which underlying value systems
      become the object of reflection, is particularly significant with respect to
      addressing social responsibility in research practices. Midstream modulation
      served to render the socio-ethical context of research visible in the laboratory 
      and helped enable research participants to more critically reflect on this
      broader context. While lab-based collaborations would benefit from being carried 
      out in concert with activities at institutional and policy levels, midstream
      modulation could prove a valuable asset in the toolbox of interdisciplinary
      methods aimed at responsible innovation.
FAU - Schuurbiers, Daan
AU  - Schuurbiers D
AD  - Centre for Society and Genomics, Radboud University Nijmegen, Nijmegen,The
      Netherlands. schuurbiers@society-genomics.nl
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20111106
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
CIN - Sci Eng Ethics. 2011 Dec;17(4):791-800. PMID: 22015948
EIN - Sci Eng Ethics. 2011 Dec;17(4):789
MH  - *Cooperative Behavior
MH  - Engineering/*ethics
MH  - *Ethics, Research
MH  - Humans
MH  - Interdisciplinary Communication
MH  - Laboratories/*ethics
MH  - Learning
MH  - Public Policy
MH  - Science/*ethics
MH  - *Social Responsibility
MH  - Social Sciences/ethics
MH  - *Social Values
PMC - PMC3242941
EDAT- 2011/11/08 06:00
MHDA- 2012/07/28 06:00
CRDT- 2011/11/08 06:00
PHST- 2010/08/14 00:00 [received]
PHST- 2011/09/22 00:00 [accepted]
PHST- 2011/11/08 06:00 [entrez]
PHST- 2011/11/08 06:00 [pubmed]
PHST- 2012/07/28 06:00 [medline]
AID - 10.1007/s11948-011-9317-8 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2011 Dec;17(4):769-88. doi: 10.1007/s11948-011-9317-8. Epub 2011 
      Nov 6.


PMID- 22057648
OWN - NLM
STAT- MEDLINE
DCOM- 20120221
LR  - 20180802
IS  - 1424-3997 (Electronic)
IS  - 0036-7672 (Linking)
VI  - 141
DP  - 2011
TI  - Prison medicine, public health policy and ethics: the Geneva experience.
PG  - w13273
LID - 10.4414/smw.2011.13273 [doi]
LID - 2011;141:w13273 [pii]
AB  - The health care of prisoners represents a public health priority. However, in
      many countries, the pursuit of public health goals in prison is not granted.
      Introducing condom distribution and syringe exchange in prisons remains the
      exception. This article describes the example of a Swiss canton in which the
      legal framework enables health-care personnel to put into practice health care
      that is equivalent to the care available to non imprisoned persons including harm
      reduction measures for prisoners. The article describes the medical institutions 
      in charge of health care for prisoners and the legal and ethical framework, its
      repercussions on the clinical and public health context, as well as persisting
      difficulties. The Geneva experience shows that in spite of the legal context,
      preventive measures, free informed consent and confidentiality have to be
      constantly defended by physicians and public health authorities. Both need to be 
      regularly educated on their obligations towards prisoner patients. A complaint
      mechanism granted to detainees as part of the legal framework is important to
      adapt existing practice to new challenges.
FAU - Elger, B S
AU  - Elger BS
AD  - Institute for Biomedical Ethics, University of Basel, CH. Bernice.Elger@unige.ch
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111107
PL  - Switzerland
TA  - Swiss Med Wkly
JT  - Swiss medical weekly
JID - 100970884
SB  - IM
MH  - Biomedical Research
MH  - Clinical Competence
MH  - Confidentiality
MH  - Delivery of Health Care/*ethics/*legislation & jurisprudence
MH  - Humans
MH  - Informed Consent
MH  - Juvenile Delinquency
MH  - Mass Screening
MH  - Primary Prevention
MH  - *Prisons
MH  - Psychiatry
MH  - *Public Health
MH  - *Public Policy
MH  - Switzerland
MH  - Treatment Refusal
MH  - Violence
EDAT- 2011/11/08 06:00
MHDA- 2012/02/22 06:00
CRDT- 2011/11/08 06:00
PHST- 2011/11/08 06:00 [entrez]
PHST- 2011/11/08 06:00 [pubmed]
PHST- 2012/02/22 06:00 [medline]
AID - smw-13273 [pii]
AID - 10.4414/smw.2011.13273 [doi]
PST - epublish
SO  - Swiss Med Wkly. 2011 Nov 7;141:w13273. doi: 10.4414/smw.2011.13273. eCollection
      2011.


PMID- 22057599
OWN - NLM
STAT- MEDLINE
DCOM- 20120221
LR  - 20111107
IS  - 0379-5284 (Print)
IS  - 0379-5284 (Linking)
VI  - 32
IP  - 11
DP  - 2011 Nov
TI  - Use of laryngeal mask airway in anesthesia for treatment of retinopathy of
      prematurity.
PG  - 1127-32
AB  - OBJECTIVE: To review clinical experience of anesthesia management using laryngeal
      mask airway (LMA) during retinopathy of prematurity (ROP) photocoagulation.
      METHODS: After obtaining the ethical approval from the Ethics Committee, we
      retrospectively reviewed the anesthesia records of 85 infants who underwent laser
      photocoagulation for ROP between June 2004 and June 2010 at the Department of
      Anesthesiology and Intensive Care, School of Medicine, Dokuz Eylul University,
      Izmir, Turkey. Anesthesia records were reviewed for airway management and
      respiratory complications in addition to medical and demographic data. RESULTS:
      The mean gestational age was 28.61+/-2.62 weeks, birth weight was
      1205.24+/-384.51 g, post-conceptional age was 38.21+/-7.01 weeks, and weight at
      the time of operation was 2323.9+/-588.6 g. Laryngeal mask airway was used with
      minimal complications in all patients, even in patients with chronic lung disease
      including bronchopulmonary dysplasia. After the ROP treatment, the LMA was
      successfully removed in all infants under deep anesthesia and none of the
      patients needed endotracheal intubation or ventilatory support. CONCLUSION:
      Laryngeal mask airway is a safe and easy to use alternative for airway management
      during laser photocoagulation procedure in infants with ROP.
FAU - Gunenc, Ferim
AU  - Gunenc F
AD  - Department of Anesthesiology and Intensive Care, School of Medicine, Dokuz Eylul 
      University, Inciralti, Izmir, Turkey. ferim.gunenc@deu.edu.tr
FAU - Kuvaki, Bahar
AU  - Kuvaki B
FAU - Iyilikci, Leyla
AU  - Iyilikci L
FAU - Gokmen, Necati
AU  - Gokmen N
FAU - Yaman, Aylin
AU  - Yaman A
FAU - Gokel, Erol
AU  - Gokel E
LA  - eng
PT  - Journal Article
PL  - Saudi Arabia
TA  - Saudi Med J
JT  - Saudi medical journal
JID - 7909441
SB  - IM
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - *Laryngeal Masks
MH  - Male
MH  - Retinopathy of Prematurity/*therapy
EDAT- 2011/11/08 06:00
MHDA- 2012/02/22 06:00
CRDT- 2011/11/08 06:00
PHST- 2011/11/08 06:00 [entrez]
PHST- 2011/11/08 06:00 [pubmed]
PHST- 2012/02/22 06:00 [medline]
AID - 20114910' [pii]
PST - ppublish
SO  - Saudi Med J. 2011 Nov;32(11):1127-32.


PMID- 22057416
OWN - NLM
STAT- MEDLINE
DCOM- 20120320
LR  - 20211021
IS  - 1672-0415 (Print)
IS  - 1672-0415 (Linking)
VI  - 17
IP  - 11
DP  - 2011 Nov
TI  - Chinese ethics review system and Chinese medicine ethical review: past, present, 
      and future.
PG  - 867-72
LID - 10.1007/s11655-011-0898-5 [doi]
AB  - The Chinese medical ethics committee and the ethical review system have made the 
      following achievements: (1) enabled the institutionalization of medical ethics,
      (2) carried out the ethics review of Chinese medicine (CM) and integrative
      medicine extensively, (3) trained a large number of ethical professionals, (4)
      supported and protected the interests of patients and subjects, and (5) ensured
      the correct direction of biological research and provided ethical defense for the
      publication of its results. However, at the same time, they are also faced with
      some new problems and difficulties that need to be resolved in the following
      ways: (1) to refine the relevant rules of ethical review, (2) to develop the
      relevant standards of the CM and integrative medicine ethical review, (3) to
      enhance the independence and authority of ethics committee, (4) to emphasize
      innovation and to discover and solve new problems, and (5) to increase
      international exchanges and improve relevant research.
FAU - Li, En-Chang
AU  - Li EC
AD  - Editorial Department of Chinese Medical Ethics, Medical School of Xi'an Jiaotong 
      University, Xi'an 710061, China.
FAU - Du, Ping
AU  - Du P
FAU - Ji, Ke-Zhou
AU  - Ji KZ
FAU - Wang, Zhen
AU  - Wang Z
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111106
PL  - China
TA  - Chin J Integr Med
JT  - Chinese journal of integrative medicine
JID - 101181180
SB  - IM
MH  - *Ethical Review
MH  - *Ethics, Medical
MH  - Humans
MH  - Integrative Medicine
MH  - Medicine, Chinese Traditional/*trends
MH  - Patient Rights
EDAT- 2011/11/08 06:00
MHDA- 2012/03/21 06:00
CRDT- 2011/11/08 06:00
PHST- 2011/04/24 00:00 [received]
PHST- 2011/11/08 06:00 [entrez]
PHST- 2011/11/08 06:00 [pubmed]
PHST- 2012/03/21 06:00 [medline]
AID - 10.1007/s11655-011-0898-5 [doi]
PST - ppublish
SO  - Chin J Integr Med. 2011 Nov;17(11):867-72. doi: 10.1007/s11655-011-0898-5. Epub
      2011 Nov 6.


PMID- 22057248
OWN - NLM
STAT- MEDLINE
DCOM- 20120716
LR  - 20220311
IS  - 1432-1084 (Electronic)
IS  - 0938-7994 (Linking)
VI  - 22
IP  - 4
DP  - 2012 Apr
TI  - Hypervascular hepatocellular carcinomas: detection with gadoxetate
      disodium-enhanced MR imaging and multiphasic multidetector CT.
PG  - 845-54
LID - 10.1007/s00330-011-2316-y [doi]
AB  - OBJECTIVES: To retrospectively compare the accuracy of detection of hypervascular
      hepatocellular carcinoma (HCC) by multiphasic multidetector CT and by gadoxetate 
      disodium-enhanced MR imaging. METHODS: After ethical approval, we analysed a
      total of 73 hypervascular HCC lesions from 31 patients suspected of having HCC,
      who underwent both gadoxetate disodium-enhanced MR imaging and multiphasic
      multidetector CT. Five blinded observers independently reviewed CT images, as
      well as dynamic MR images alone and combined with hepatobiliary phase MR images. 
      Diagnostic accuracy (Az values), sensitivities and positive predictive values
      were compared by using the Scheffe post hoc test. RESULTS: The mean Az value for 
      dynamic and hepatobiliary phase MR combined (0.81) or dynamic MR images alone
      (0.78) was significantly higher than that for CT images (0.67, P < 0.001, 0.005, 
      respectively). The mean sensitivity of the combined MR images (0.67) was
      significantly higher than that of dynamic MR alone (0.52, P < 0.05) or CT images 
      (0.44, P < 0.05). The mean positive predictive values were 0.96, 0.95 and 0.94,
      for CT, dynamic MR alone and combined MR images, respectively. CONCLUSIONS:
      Compared with multiphasic multidetector CT, gadoxetate disodium-enhanced MR
      imaging combining dynamic and hepatobiliary phase images results in significantly
      improved sensitivity and diagnostic accuracy for detection of hypervascular HCC. 
      KEY POINTS: Gadoxetate disodium is a new liver-specific MR imaging contrast
      agent. Gadoxetate disodium-enhanced MRI helps the assessment of patients with
      liver disease. It showed high diagnostic accuracy for the detection of
      hepatocellular carcinoma.
FAU - Onishi, Hiromitsu
AU  - Onishi H
AD  - Department of Radiology, Osaka University Graduate School of Medicine, 2-2,
      Yamadaoka, Suita, Osaka, 565-0871, Japan. h-onishi@iris.dti.ne.jp
FAU - Kim, Tonsok
AU  - Kim T
FAU - Imai, Yasuharu
AU  - Imai Y
FAU - Hori, Masatoshi
AU  - Hori M
FAU - Nagano, Hiroaki
AU  - Nagano H
FAU - Nakaya, Yasuhiro
AU  - Nakaya Y
FAU - Tsuboyama, Takahiro
AU  - Tsuboyama T
FAU - Nakamoto, Atsushi
AU  - Nakamoto A
FAU - Tatsumi, Mitsuaki
AU  - Tatsumi M
FAU - Kumano, Seishi
AU  - Kumano S
FAU - Okada, Masahiro
AU  - Okada M
FAU - Takamura, Manabu
AU  - Takamura M
FAU - Wakasa, Kenichi
AU  - Wakasa K
FAU - Tomiyama, Noriyuki
AU  - Tomiyama N
FAU - Murakami, Takamichi
AU  - Murakami T
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111107
PL  - Germany
TA  - Eur Radiol
JT  - European radiology
JID - 9114774
RN  - 0 (Contrast Media)
RN  - 0 (gadolinium ethoxybenzyl DTPA)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Hepatocellular/*diagnosis
MH  - Contrast Media
MH  - Female
MH  - *Gadolinium DTPA
MH  - Humans
MH  - Liver Neoplasms/*diagnosis
MH  - Magnetic Resonance Imaging/*methods
MH  - Middle Aged
MH  - Neovascularization, Pathologic/*diagnosis
MH  - Observer Variation
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2011/11/08 06:00
MHDA- 2012/07/17 06:00
CRDT- 2011/11/08 06:00
PHST- 2011/07/04 00:00 [received]
PHST- 2011/10/15 00:00 [accepted]
PHST- 2011/09/29 00:00 [revised]
PHST- 2011/11/08 06:00 [entrez]
PHST- 2011/11/08 06:00 [pubmed]
PHST- 2012/07/17 06:00 [medline]
AID - 10.1007/s00330-011-2316-y [doi]
PST - ppublish
SO  - Eur Radiol. 2012 Apr;22(4):845-54. doi: 10.1007/s00330-011-2316-y. Epub 2011 Nov 
      7.


PMID- 22056907
OWN - NLM
STAT- MEDLINE
DCOM- 20120119
LR  - 20190521
IS  - 0065-3268 (Print)
IS  - 0065-3268 (Linking)
VI  - 32
DP  - 2012
TI  - Relational ethics and psychosomatic assessment.
PG  - 223-239
LID - 10.1159/000330039 [doi]
AB  - The main ethical perspective in the clinical relationship takes into
      consideration the vulnerability of the clinical condition before threats and
      risks that can undermine the integrity and dignity of the person. Psychosomatic
      medicine faces complex cases whose ethical problems cannot only be solved by
      applying top-down deontological or utilitarian approaches, principlism, which is 
      limited mainly to easing ethical tensions, or a bottom-up approach, the casuistic
      model, case-based reasoning. In introducing vulnerability as the core of ethical 
      questioning as a principle ontological priority over other principles, relational
      ethics refers to the appreciation of the responsibility of health professionals
      through which a health care professional and the patient 'together' can construct
      more reasonable and prudential courses of action with, for, and by the patient.
      The model of relational ethics is based on three main aspects, clinically
      integrated approach, science/philosophy partnership, and deliberative process,
      that when taken together, form an intermediate model that ensures prudent and
      reasonable decision-making. The three structural elements and characteristics of 
      relational ethics create and maintain a responsible relationship between the
      professional and the patient being aware that the mutual vulnerability of health 
      professional and the patient has a moral value and recognizing that their
      relationship will allow for personal development of each. I conceptualized the
      model of relational ethics as one that embraces the meta-ethical principles of
      vulnerability, dignity, responsibility, and respect for autonomy as they are
      considered by many international declarations or conventions. This model
      integrates three key polarities: ensure conditions of authenticity, facilitate a 
      process of cooperative mutuality, and promote opportunities for growth and
      development. Relational ethics can be used to solve major ethical problems in
      psychosomatic medicine, capacity , informed consent, and confidentiality.
CI  - Copyright (c) 2012 S. Karger AG, Basel.
FAU - Barbosa, Antonio
AU  - Barbosa A
AD  - Center for Bioethics, Faculty of Medicine, University of Lisbon, and Psychiatry
      Department, Hospital de Santa Maria, Lisbon, Portugal.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111019
PL  - Switzerland
TA  - Adv Psychosom Med
JT  - Advances in psychosomatic medicine
JID - 0101303
SB  - IM
MH  - Adaptation, Psychological
MH  - Communication
MH  - Comorbidity
MH  - Confidentiality
MH  - Cooperative Behavior
MH  - *Ethics, Medical
MH  - Humans
MH  - Informed Consent
MH  - Interdisciplinary Communication
MH  - Mental Competency
MH  - Mental Disorders/diagnosis/psychology
MH  - Negotiating
MH  - Personality Assessment
MH  - Physician-Patient Relations/*ethics
MH  - Psychophysiologic Disorders/*diagnosis/*psychology
MH  - Referral and Consultation
MH  - Sick Role
EDAT- 2011/11/08 06:00
MHDA- 2012/01/20 06:00
CRDT- 2011/11/08 06:00
PHST- 2011/11/08 06:00 [entrez]
PHST- 2011/11/08 06:00 [pubmed]
PHST- 2012/01/20 06:00 [medline]
AID - 000330039 [pii]
AID - 10.1159/000330039 [doi]
PST - ppublish
SO  - Adv Psychosom Med. 2012;32:223-239. doi: 10.1159/000330039. Epub 2011 Oct 19.


PMID- 22056687
OWN - NLM
STAT- MEDLINE
DCOM- 20120228
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 262
IP  - 1
DP  - 2012 Jan
TI  - Correlation of contrast-detail analysis and clinical image quality assessment in 
      chest radiography with a human cadaver study.
PG  - 298-304
LID - 10.1148/radiol.11110447 [doi]
AB  - PURPOSE: To determine the correlation between the clinical and physical image
      quality of chest images by using cadavers embalmed with the Thiel technique and a
      contrast-detail phantom. MATERIALS AND METHODS: The use of human cadavers
      fulfilled the requirements of the institutional ethics committee. Clinical image 
      quality was assessed by using three human cadavers embalmed with the Thiel
      technique, which results in excellent preservation of the flexibility and
      plasticity of organs and tissues. As a result, lungs can be inflated during image
      acquisition to simulate the pulmonary anatomy seen on a chest radiograph. Both
      contrast-detail phantom images and chest images of the Thiel-embalmed bodies were
      acquired with an amorphous silicon flat-panel detector. Tube voltage (70, 81, 90,
      100, 113, 125 kVp), copper filtration (0.1, 0.2, 0.3 mm Cu), and exposure
      settings (200, 280, 400, 560, 800 speed class) were altered to simulate different
      quality levels. Four experienced radiologists assessed the image quality by using
      a visual grading analysis (VGA) technique based on European Quality Criteria for 
      Chest Radiology. The phantom images were scored manually and automatically with
      use of dedicated software, both resulting in an inverse image quality figure
      (IQF). Spearman rank correlations between inverse IQFs and VGA scores were
      calculated. RESULTS: A statistically significant correlation (r = 0.80, P < .01) 
      was observed between the VGA scores and the manually obtained inverse IQFs.
      Comparison of the VGA scores and the automated evaluated phantom images showed an
      even better correlation (r = 0.92, P < .001). CONCLUSION: The results support the
      value of contrast-detail phantom analysis for evaluating clinical image quality
      in chest radiography.
CI  - (c) RSNA, 2011.
FAU - De Crop, An
AU  - De Crop A
AD  - Department of Basic Medical Sciences, Ghent University, Proeftuinstraat 86,
      B-9000 Ghent, Belgium. An.decrop@ugent.be
FAU - Bacher, Klaus
AU  - Bacher K
FAU - Van Hoof, Tom
AU  - Van Hoof T
FAU - Smeets, Peter V
AU  - Smeets PV
FAU - Smet, Barbara S
AU  - Smet BS
FAU - Vergauwen, Merel
AU  - Vergauwen M
FAU - Kiendys, Urszula
AU  - Kiendys U
FAU - Duyck, Philippe
AU  - Duyck P
FAU - Verstraete, Koenraad
AU  - Verstraete K
FAU - D'Herde, Katharina
AU  - D'Herde K
FAU - Thierens, Hubert
AU  - Thierens H
LA  - eng
PT  - Journal Article
DEP - 20111104
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Cadaver
MH  - Confidence Intervals
MH  - Embalming/methods
MH  - Female
MH  - Humans
MH  - Least-Squares Analysis
MH  - Linear Models
MH  - Lung/*diagnostic imaging
MH  - Male
MH  - Phantoms, Imaging
MH  - Radiographic Image Interpretation, Computer-Assisted
MH  - Radiography, Thoracic/instrumentation/*methods
EDAT- 2011/11/08 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/11/08 06:00
PHST- 2011/11/08 06:00 [entrez]
PHST- 2011/11/08 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - radiol.11110447 [pii]
AID - 10.1148/radiol.11110447 [doi]
PST - ppublish
SO  - Radiology. 2012 Jan;262(1):298-304. doi: 10.1148/radiol.11110447. Epub 2011 Nov
      4.


PMID- 22056670
OWN - NLM
STAT- MEDLINE
DCOM- 20111214
LR  - 20220408
IS  - 1549-5477 (Electronic)
IS  - 0890-9369 (Linking)
VI  - 25
IP  - 21
DP  - 2011 Nov 1
TI  - Rejuvenating senescent and centenarian human cells by reprogramming through the
      pluripotent state.
PG  - 2248-53
LID - 10.1101/gad.173922.111 [doi]
AB  - Direct reprogramming of somatic cells into induced pluripotent stem cells (iPSCs)
      provides a unique opportunity to derive patient-specific stem cells with
      potential applications in tissue replacement therapies and without the ethical
      concerns of human embryonic stem cells (hESCs). However, cellular senescence,
      which contributes to aging and restricted longevity, has been described as a
      barrier to the derivation of iPSCs. Here we demonstrate, using an optimized
      protocol, that cellular senescence is not a limit to reprogramming and that
      age-related cellular physiology is reversible. Thus, we show that our iPSCs
      generated from senescent and centenarian cells have reset telomere size, gene
      expression profiles, oxidative stress, and mitochondrial metabolism, and are
      indistinguishable from hESCs. Finally, we show that senescent and
      centenarian-derived pluripotent stem cells are able to redifferentiate into fully
      rejuvenated cells. These results provide new insights into iPSC technology and
      pave the way for regenerative medicine for aged patients.
FAU - Lapasset, Laure
AU  - Lapasset L
AD  - Laboratory of Plasticity of the Genome and Aging, Institute of Functional
      Genomics, Montpellier Cedex, France.
FAU - Milhavet, Ollivier
AU  - Milhavet O
FAU - Prieur, Alexandre
AU  - Prieur A
FAU - Besnard, Emilie
AU  - Besnard E
FAU - Babled, Amelie
AU  - Babled A
FAU - Ait-Hamou, Nafissa
AU  - Ait-Hamou N
FAU - Leschik, Julia
AU  - Leschik J
FAU - Pellestor, Franck
AU  - Pellestor F
FAU - Ramirez, Jean-Marie
AU  - Ramirez JM
FAU - De Vos, John
AU  - De Vos J
FAU - Lehmann, Sylvain
AU  - Lehmann S
FAU - Lemaitre, Jean-Marc
AU  - Lemaitre JM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genes Dev
JT  - Genes & development
JID - 8711660
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Animals
MH  - *Cell Differentiation
MH  - Cell Line
MH  - Cells, Cultured
MH  - *Cellular Reprogramming
MH  - Cellular Senescence/drug effects/*genetics
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*cytology
MH  - Mice
MH  - Mice, Inbred NOD
MH  - Mice, SCID
MH  - Mitochondria/metabolism
MH  - *Rejuvenation
MH  - Telomere/genetics/metabolism
MH  - Transcription Factors/pharmacology
PMC - PMC3219229
EDAT- 2011/11/08 06:00
MHDA- 2011/12/15 06:00
CRDT- 2011/11/08 06:00
PHST- 2011/11/08 06:00 [entrez]
PHST- 2011/11/08 06:00 [pubmed]
PHST- 2011/12/15 06:00 [medline]
AID - 25/21/2248 [pii]
AID - 10.1101/gad.173922.111 [doi]
PST - ppublish
SO  - Genes Dev. 2011 Nov 1;25(21):2248-53. doi: 10.1101/gad.173922.111.


PMID- 22055981
OWN - NLM
STAT- MEDLINE
DCOM- 20120306
LR  - 20151119
IS  - 1877-5764 (Electronic)
IS  - 1877-5756 (Linking)
VI  - 2
IP  - 4
DP  - 2011 Nov
TI  - Midwives at youth clinics attitude to HPV vaccination and their role in cervical 
      cancer prevention.
PG  - 137-42
LID - 10.1016/j.srhc.2011.09.001 [doi]
AB  - OBJECTIVE: To explore youth clinic midwives role in cervical cancer prevention
      and their attitude to HPV vaccination. STUDY DESIGN: Individual interviews with
      13 midwives working at youth clinics in Sweden. The interviews were recorded,
      transcribed, and analysed by qualitative content analysis. RESULTS: Three themes 
      were identified in the qualitative content analysis: "Cervical cancer prevention 
      not a prioritised area", "Ambivalence to the HPV vaccine", and "Gender and
      socioeconomic controversies". Few midwives talked spontaneously about cervical
      cancer prevention. The responsibility for providing information about HPV
      vaccination was considered as primarily that of school health nurses and parents.
      Midwives were positive about the HPV vaccination, but recognised certain risks,
      such as its potential negative impact on cervical cancer screening and increased 
      sexual risk taking. The midwives expressed concerns with medical risks, such as
      side effects and unknown long-term effects of the HPV vaccine. The midwives in
      the study had ethical concerns that boys were not included in the program and not
      all families had the financial resources to vaccinate their children. Thus, weak 
      socioeconomic groups might be excluded. CONCLUSION: The midwives considered
      cervical cancer prevention as important, but did not integrate information on the
      HPV vaccine into their routine work, mainly because young people visiting youth
      clinics had had their sexual debut and they were concerned about the medical
      risks and that the vaccine was too expensive.
CI  - Copyright A(c) 2011 Elsevier B.V. All rights reserved.
FAU - Oscarsson, Marie G
AU  - Oscarsson MG
AD  - School of Health and Caring Sciences, Linnaeus University, Sweden.
      marie.oscarsson@lnu.se
FAU - Dahlberg, Annica
AU  - Dahlberg A
FAU - Tyden, Tanja
AU  - Tyden T
LA  - eng
PT  - Journal Article
DEP - 20111008
PL  - Netherlands
TA  - Sex Reprod Healthc
JT  - Sexual & reproductive healthcare : official journal of the Swedish Association of
      Midwives
JID - 101530546
RN  - 0 (Papillomavirus Vaccines)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Ambulatory Care Facilities
MH  - *Attitude of Health Personnel
MH  - Child
MH  - Dissent and Disputes
MH  - Ethics
MH  - Female
MH  - Humans
MH  - Information Dissemination
MH  - Interviews as Topic
MH  - Male
MH  - Middle Aged
MH  - *Midwifery
MH  - Papillomavirus Infections/*prevention & control
MH  - *Papillomavirus Vaccines/adverse effects
MH  - Practice Patterns, Nurses'
MH  - *Professional Role
MH  - Qualitative Research
MH  - Socioeconomic Factors
MH  - Sweden
MH  - Uterine Cervical Neoplasms/*prevention & control
MH  - Young Adult
EDAT- 2011/11/08 06:00
MHDA- 2012/03/07 06:00
CRDT- 2011/11/08 06:00
PHST- 2011/05/24 00:00 [received]
PHST- 2011/08/11 00:00 [revised]
PHST- 2011/09/23 00:00 [accepted]
PHST- 2011/11/08 06:00 [entrez]
PHST- 2011/11/08 06:00 [pubmed]
PHST- 2012/03/07 06:00 [medline]
AID - S1877-5756(11)00032-2 [pii]
AID - 10.1016/j.srhc.2011.09.001 [doi]
PST - ppublish
SO  - Sex Reprod Healthc. 2011 Nov;2(4):137-42. doi: 10.1016/j.srhc.2011.09.001. Epub
      2011 Oct 8.


PMID- 22055800
OWN - NLM
STAT- MEDLINE
DCOM- 20120305
LR  - 20111107
IS  - 1878-4046 (Electronic)
IS  - 1076-6332 (Linking)
VI  - 18
IP  - 12
DP  - 2011 Dec
TI  - A report on the current status of grand rounds in radiology residency programs in
      the United States.
PG  - 1593-7
LID - 10.1016/j.acra.2011.08.015 [doi]
AB  - RATIONALE AND OBJECTIVES: A national needs assessment of radiology program
      directors was performed to characterize grand rounds (GR) programs, assess the
      perceived educational value of GR programs, and determine the impact of the
      recent economic downturn on GR. MATERIALS AND METHODS: A 28-question survey was
      developed querying the organizational logistics of GR programs, types of
      speakers, content of talks, honoraria, types of speakers invited, response to the
      economic downturn, types of speaker interaction with residents, and perceived
      educational value of GR. Questions were in multiple-choice, yes-or-no, and
      five-point Likert-type formats. The survey was distributed to the program
      directors of all radiology residencies within the United States. RESULTS:
      Fifty-seven of 163 programs responded, resulting in a response rate of 36%.
      Thirty-eight programs (67%) were university residencies and 10 (18%) were
      university affiliated. Eighty-two percent of university and 60% of
      university-affiliated residencies had their own GR programs, while only 14% of
      community and no military residencies held GR. GR were held weekly in 18% of
      programs, biweekly in 8%, monthly in 42%, bimonthly in 16%, and less frequently
      than every 2 months in 16%. All 38 programs hosting GR reported a broad spectrum 
      of presentations, including talks on medical education (66%), clinical and
      evidence-based medicine (55%), professionalism (45%), ethics (45%), quality
      assurance (34%), global health (26%), and resident presentations (26%). All
      programs invited speakers from outside the institution, but there was variability
      with regard to the frequency of visits and whether invited speakers were from out
      of town. As a result of recent economic events, one radiology residency (3%)
      completely canceled its GR program. Others decreased the number of speakers from 
      outside their cities (40%) or decreased the number of speakers from within their 
      own cities (16%). Honoraria were paid to speakers by 95% of responding programs. 
      Most program directors (79%) who had their own GR programs either strongly agreed
      or agreed that GR are an essential component of any academic radiology
      department, and this opinion was shared by a majority of all respondents (68%).
      Almost all respondents (97%) either strongly agreed or agreed that general
      radiologic education of imaging subspecialists is valuable in an academic
      radiology department. A majority (65%) either strongly agreed or agreed that
      attendance at GR should be expected of all attending radiologists. CONCLUSIONS:
      GR programs among radiology residencies tend to have similar formats involving
      invited speakers, although the frequency, types of talks, and honoraria may vary 
      slightly. Most programs value GR, and all programs integrate GR within resident
      education to some degree. The recent economic downturn has led to a decrease in
      the number of invited visiting speakers but not to a decrease in the amounts of
      honoraria.
CI  - Copyright A(c) 2011 AUR. Published by Elsevier Inc. All rights reserved.
FAU - Yablon, Corrie M
AU  - Yablon CM
AD  - Department of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline
      Avenue, Boston, MA 02215, USA. cyablon@bidmc.harvard.edu
FAU - Wu, Jim S
AU  - Wu JS
FAU - Slanetz, Priscilla J
AU  - Slanetz PJ
FAU - Eisenberg, Ronald L
AU  - Eisenberg RL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Acad Radiol
JT  - Academic radiology
JID - 9440159
SB  - IM
MH  - Data Collection
MH  - Internship and Residency/*methods
MH  - Radiology/*education
MH  - United States
EDAT- 2011/11/08 06:00
MHDA- 2012/03/06 06:00
CRDT- 2011/11/08 06:00
PHST- 2011/07/09 00:00 [received]
PHST- 2011/08/11 00:00 [revised]
PHST- 2011/08/22 00:00 [accepted]
PHST- 2011/11/08 06:00 [entrez]
PHST- 2011/11/08 06:00 [pubmed]
PHST- 2012/03/06 06:00 [medline]
AID - S1076-6332(11)00429-6 [pii]
AID - 10.1016/j.acra.2011.08.015 [doi]
PST - ppublish
SO  - Acad Radiol. 2011 Dec;18(12):1593-7. doi: 10.1016/j.acra.2011.08.015.


PMID- 22054806
OWN - NLM
STAT- MEDLINE
DCOM- 20120418
LR  - 20161125
IS  - 1878-4046 (Electronic)
IS  - 1076-6332 (Linking)
VI  - 19
IP  - 1
DP  - 2012 Jan
TI  - Effect of scan time on perfusion and flow extraction product (K-trans)
      measurements in lung cancer using low-dose volume perfusion CT (VPCT).
PG  - 78-83
LID - 10.1016/j.acra.2011.09.010 [doi]
AB  - RATIONALE AND OBJECTIVES: To assess the effect of measurement time on blood flow 
      (BF), blood volume (BV), and k-trans-values (flow extraction product) in patients
      undergoing volume perfusion computed tomography (VPCT) for lung cancer. MATERIALS
      AND METHODS: This prospective study was approved by our local Research Ethics
      Committee and informed consent was obtained in all patients. Between December
      2009 and December 2010, 75 VPCT scans were obtained in 54 consecutive patients
      (15 women, 39 men) with histologically confirmed lung cancer. A 64-second VPCT of
      the tumor (80 kV, 60 mAs) using 128 x 0.6-mm collimation, 6.9-cm z-axis coverage 
      and a total of 26 volume measurements, was performed. BF, BV, and K(trans) were
      determined. Data evaluation was performed for different measurement times (64
      seconds, 45 seconds, 39 seconds, and 36 seconds) by removing the last two, four, 
      and five scans and repeating the analysis. A one-way repeated-measures analysis
      of variance was used to test for effects of measurement time on BF, BV, and
      k-trans and unpaired/paired Student t-tests were applied for comparisons
      within/between groups, respectively. RESULTS: No effect of measurement time on BF
      values was noted (P > .05), whereas a significant decrease of BV values (at 39
      seconds: 71% +/- 2% of 64-second values) and a significant increase of
      k-trans-values (at 39 seconds: 146% +/- 8% of 64-second values) were observed
      with progressively shortened measurement time (P < .05, respectively).
      Additionally, with reduced measurement time, the increase in k-trans-values was
      significantly more pronounced in those patient groups with higher BV (at 39
      seconds: 171% +/- 15% versus 120% +/- 3% of 64-second measurements), and those
      with lower k-trans (at 39 seconds: 167% +/- 16% versus 126% +/- 4% of 64-second
      measurements) (P < .05, respectively). CONCLUSION: Whereas estimation of BF in
      lung cancer was independent from VPCT measurement time within the chosen ranges, 
      approximation of both BV and k-trans was affected by measurement duration. A
      fixed measurement time of 40 seconds is recommended.
CI  - Copyright (c) 2012 AUR. Published by Elsevier Inc. All rights reserved.
FAU - Spira, Daniel
AU  - Spira D
AD  - Department of Diagnostic Radiology, Eberhard-Karls-University, Hoppe-Seyler-Str. 
      3, 72076 Tubingen, Germany. daniel.spira@med.uni-tuebingen.de
FAU - Gerlach, Jennifer Denise
AU  - Gerlach JD
FAU - Spira, Sven Michael
AU  - Spira SM
FAU - Schulze, Maximilian
AU  - Schulze M
FAU - Sauter, Alexander
AU  - Sauter A
FAU - Horger, Marius
AU  - Horger M
LA  - eng
PT  - Journal Article
DEP - 20111103
PL  - United States
TA  - Acad Radiol
JT  - Academic radiology
JID - 9440159
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Algorithms
MH  - Blood Flow Velocity
MH  - Blood Volume
MH  - Blood Volume Determination/methods
MH  - Female
MH  - Humans
MH  - Imaging, Three-Dimensional/*methods
MH  - Lung Neoplasms/*diagnostic imaging/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Perfusion Imaging/*methods
MH  - Radiation Dosage
MH  - Radiographic Image Interpretation, Computer-Assisted/*methods
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Time Factors
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2011/11/08 06:00
MHDA- 2012/04/19 06:00
CRDT- 2011/11/08 06:00
PHST- 2011/08/08 00:00 [received]
PHST- 2011/09/13 00:00 [revised]
PHST- 2011/09/13 00:00 [accepted]
PHST- 2011/11/08 06:00 [entrez]
PHST- 2011/11/08 06:00 [pubmed]
PHST- 2012/04/19 06:00 [medline]
AID - S1076-6332(11)00440-5 [pii]
AID - 10.1016/j.acra.2011.09.010 [doi]
PST - ppublish
SO  - Acad Radiol. 2012 Jan;19(1):78-83. doi: 10.1016/j.acra.2011.09.010. Epub 2011 Nov
      3.


PMID- 22054565
OWN - NLM
STAT- MEDLINE
DCOM- 20120613
LR  - 20151119
IS  - 1095-8630 (Electronic)
IS  - 0301-4797 (Linking)
VI  - 93
IP  - 1
DP  - 2012 Jan
TI  - Exploring the relationship between public environmental ethics and river flood
      policies in western Europe.
PG  - 1-9
LID - 10.1016/j.jenvman.2011.08.020 [doi]
AB  - Two styles of river flood management can be distinguished: dike reinforcement and
      the more sustainable 'Room for River' option. This paper investigates public
      adherences to these two management styles and whether their adherence correlates 
      with their Visions of Nature. The focus is especially on people's image of the
      appropriate human/nature relationship, i.e. Mastery over nature, Stewardship of
      nature, Partnership of nature or Participation in nature. Other variables that
      are part of the analysis are the respondents' sense of place, safety perception
      and background variables. The results of a written survey among riverside
      residents in France, Germany and the Netherlands (N = 1811) show high adherences 
      to the Room for River style and a rejection of dike reinforcement. A regression
      analysis shows that adherence to the Room for River style correlates with
      adherence to the image of Stewardship, while adherence to dike reinforcement is
      predicted by Mastery over nature. Thus, according to the public a policy shift
      from dike reinforcement to a more sustainable style is seen as a fundamental one,
      connected to a change in environmental ethics.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - de Groot, Mirjam
AU  - de Groot M
AD  - Centre for Sustainable Management of Resources, Radboud University Nijmegen, P.O.
      Box 9010, 6500 GL Nijmegen, The Netherlands. mirjam.degroot@wur.nl
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110915
PL  - England
TA  - J Environ Manage
JT  - Journal of environmental management
JID - 0401664
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Conservation of Natural Resources
MH  - *Environmental Policy
MH  - *Floods
MH  - France
MH  - Germany
MH  - Humans
MH  - Middle Aged
MH  - Netherlands
MH  - *Public Opinion
MH  - Regression Analysis
MH  - Residence Characteristics
MH  - *Rivers
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2011/11/08 06:00
MHDA- 2012/06/14 06:00
CRDT- 2011/11/08 06:00
PHST- 2010/02/23 00:00 [received]
PHST- 2011/08/05 00:00 [revised]
PHST- 2011/08/23 00:00 [accepted]
PHST- 2011/11/08 06:00 [entrez]
PHST- 2011/11/08 06:00 [pubmed]
PHST- 2012/06/14 06:00 [medline]
AID - S0301-4797(11)00319-7 [pii]
AID - 10.1016/j.jenvman.2011.08.020 [doi]
PST - ppublish
SO  - J Environ Manage. 2012 Jan;93(1):1-9. doi: 10.1016/j.jenvman.2011.08.020. Epub
      2011 Sep 15.


PMID- 22054494
OWN - NLM
STAT- MEDLINE
DCOM- 20120517
LR  - 20120116
IS  - 1600-6143 (Electronic)
IS  - 1600-6135 (Linking)
VI  - 12
IP  - 1
DP  - 2012 Jan
TI  - The use of kidneys with small renal tumors for transplantation: who is taking the
      risk?
PG  - 48-54
LID - 10.1111/j.1600-6143.2011.03794.x [doi]
AB  - The ever-increasing disparity between the number of organs available for
      transplant and the need for organs drives further exploration into the use of
      compromised or marginal donors. There is now an emerging advocacy for the use of 
      kidneys with existing tumors, which may be rendered tumor free after surgical
      excision and reconstruction. This practice is based on reliable data that renal
      cancers <3 cm in diameter behave with minimal malignant potential and likelihood 
      of transmission to the immunosuppressed recipient. However, in the case of live
      donors this creates a potential ethical conflict between those treating patients 
      with renal masses and those with an interest in renal donation. The best
      available treatment for patients with a small renal tumor is a form of
      nephron-sparing tumor excision or ablation, as this approach provides for the
      maximum amount of residual kidney function and enhances survival. Thus, patients 
      newly diagnosed with small renal tumors should be referred to centers with
      expertise in nephron sparing techniques, not transplant centers. In the case of
      an individual undergoing a live donor evaluation in which a small renal tumor is 
      detected, a careful analysis of risk and benefit for the potential donor and the 
      recipient is indicated.
CI  - (c)Copyright 2011 The American Society of Transplantation and the American
      Society of Transplant Surgeons.
FAU - Flechner, S M
AU  - Flechner SM
AD  - The Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH,
      USA. flechns@ccf.org
FAU - Campbell, S C
AU  - Campbell SC
LA  - eng
PT  - Journal Article
DEP - 20111104
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
SB  - IM
MH  - Humans
MH  - *Kidney Neoplasms/epidemiology/pathology
MH  - *Kidney Transplantation
MH  - Likelihood Functions
MH  - Neoplasm Metastasis
MH  - Risk Assessment
EDAT- 2011/11/08 06:00
MHDA- 2012/05/18 06:00
CRDT- 2011/11/08 06:00
PHST- 2011/11/08 06:00 [entrez]
PHST- 2011/11/08 06:00 [pubmed]
PHST- 2012/05/18 06:00 [medline]
AID - 10.1111/j.1600-6143.2011.03794.x [doi]
PST - ppublish
SO  - Am J Transplant. 2012 Jan;12(1):48-54. doi: 10.1111/j.1600-6143.2011.03794.x.
      Epub 2011 Nov 4.


PMID- 22054157
OWN - NLM
STAT- MEDLINE
DCOM- 20120103
LR  - 20111107
IS  - 1558-3171 (Electronic)
IS  - 0039-6109 (Linking)
VI  - 91
IP  - 6
DP  - 2011 Dec
TI  - Adolescent bariatric surgery.
PG  - 1339-51, x
LID - 10.1016/j.suc.2011.08.005 [doi]
AB  - Obesity has become an increasingly serious problem in pediatric and adolescent
      populations in the United States. Although bariatric surgery has been offered to 
      morbidly obese adolescents for the past several decades, it remains
      controversial. However, the benefits of weight loss surgery in this population
      have been realized, particularly its long-term physical and emotional effects on 
      adolescents. This article reviews the demographics and health implications of
      adolescent obesity, describes the most common adolescent bariatric surgical
      procedures and their outcomes, discusses the ethical issues involved in elective 
      surgery in this population, and outlines the key components of an adolescent
      bariatric surgical program.
CI  - Copyright A(c) 2011 Elsevier Inc. All rights reserved.
FAU - Ibele, Anna R
AU  - Ibele AR
AD  - Minimally Invasive and Bariatric Surgery, Department of Surgery, Indiana
      University School of Medicine, 545 Barnhill Drive, Emerson Hall 203,
      Indianapolis, IN 46202, USA.
FAU - Mattar, Samer G
AU  - Mattar SG
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Surg Clin North Am
JT  - The Surgical clinics of North America
JID - 0074243
SB  - IM
MH  - Adolescent
MH  - *Bariatric Surgery
MH  - Behavior Therapy
MH  - Body Mass Index
MH  - Comorbidity
MH  - Diabetes Mellitus/epidemiology
MH  - Humans
MH  - Obesity, Morbid/epidemiology/psychology/surgery
MH  - Patient Selection
MH  - Practice Guidelines as Topic
MH  - Treatment Outcome
EDAT- 2011/11/08 06:00
MHDA- 2012/01/04 06:00
CRDT- 2011/11/08 06:00
PHST- 2011/11/08 06:00 [entrez]
PHST- 2011/11/08 06:00 [pubmed]
PHST- 2012/01/04 06:00 [medline]
AID - S0039-6109(11)00099-5 [pii]
AID - 10.1016/j.suc.2011.08.005 [doi]
PST - ppublish
SO  - Surg Clin North Am. 2011 Dec;91(6):1339-51, x. doi: 10.1016/j.suc.2011.08.005.


PMID- 22054039
OWN - NLM
STAT- MEDLINE
DCOM- 20120329
LR  - 20220408
IS  - 1600-6143 (Electronic)
IS  - 1600-6135 (Linking)
VI  - 11
IP  - 12
DP  - 2011 Dec
TI  - Living kidney donor follow-up: state-of-the-art and future directions, conference
      summary and recommendations.
PG  - 2561-8
LID - 10.1111/j.1600-6143.2011.03816.x [doi]
AB  - In light of continued uncertainty regarding postkidney donation medical,
      psychosocial and socioeconomic outcomes for traditional living donors and
      especially for donors meeting more relaxed acceptance criteria, a meeting was
      held in September 2010 to (1) review limitations of existing data on outcomes of 
      living kidney donors; (2) assess and define the need for long-term follow-up of
      living kidney donors; (3) identify the potential system requirements,
      infrastructure and costs of long-term follow-up for living kidney donor outcomes 
      in the United States and (4) explore practical options for future development and
      funding of United States living kidney donor data collection, metrics and
      endpoints. Conference participants included prior kidney donors, physicians,
      surgeons, medical ethicists, social scientists, donor coordinators, social
      workers, independent donor advocates and representatives of payer organizations
      and the federal government. The findings and recommendations generated at this
      meeting are presented.
CI  - (c)Copyright 2011 The American Society of Transplantation and the American
      Society of Transplant Surgeons.
CN  - Living Kidney Donor Follow-Up Conference Writing Group
FAU - Leichtman, Alan
AU  - Leichtman A
FAU - Abecassis, Michael
AU  - Abecassis M
FAU - Barr, Mark
AU  - Barr M
FAU - Charlton, Marian
AU  - Charlton M
FAU - Cohen, David
AU  - Cohen D
FAU - Confer, Dennis
AU  - Confer D
FAU - Cooper, Mathew
AU  - Cooper M
FAU - Danovitch, Gabriel
AU  - Danovitch G
FAU - Davis, Connie
AU  - Davis C
FAU - Delmonico, Francis
AU  - Delmonico F
FAU - Dew, Mary Amanda
AU  - Dew MA
FAU - Garvey, Cathy
AU  - Garvey C
FAU - Gaston, Robert
AU  - Gaston R
FAU - Gill, John
AU  - Gill J
FAU - Gillespie, Brenda
AU  - Gillespie B
FAU - Ibrahim, Hassan
AU  - Ibrahim H
FAU - Jacobs, Cheryl
AU  - Jacobs C
FAU - Kahn, Jeffery
AU  - Kahn J
FAU - Kasiske, Bert
AU  - Kasiske B
FAU - Kim, Joseph
AU  - Kim J
FAU - Lentine, Krista
AU  - Lentine K
FAU - Manyalich, Marti
AU  - Manyalich M
FAU - Medina-Pestana, Jose
AU  - Medina-Pestana J
FAU - Merion, Robert
AU  - Merion R
FAU - Moxey-Mims, Marva
AU  - Moxey-Mims M
FAU - Odim, Jonah
AU  - Odim J
FAU - Opelz, Gerhard
AU  - Opelz G
FAU - Orlowski, Janice
AU  - Orlowski J
FAU - Rizvi, Abid
AU  - Rizvi A
FAU - Roberts, John
AU  - Roberts J
FAU - Segev, Dorry L
AU  - Segev DL
FAU - Sledge, Tina
AU  - Sledge T
FAU - Steiner, Robert
AU  - Steiner R
FAU - Taler, Sandra
AU  - Taler S
FAU - Textor, Steven
AU  - Textor S
FAU - Thiel, Gil
AU  - Thiel G
FAU - Waterman, Amy
AU  - Waterman A
FAU - Williams, Errol
AU  - Williams E
FAU - Wolfe, Robert
AU  - Wolfe R
FAU - Wynn, James
AU  - Wynn J
FAU - Matas, Arthur J
AU  - Matas AJ
LA  - eng
PT  - Journal Article
DEP - 20111104
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
SB  - IM
MH  - Congresses as Topic
MH  - Follow-Up Studies
MH  - Humans
MH  - Kidney Transplantation/*standards
MH  - Living Donors/*psychology/*statistics & numerical data
EDAT- 2011/11/08 06:00
MHDA- 2012/03/30 06:00
CRDT- 2011/11/08 06:00
PHST- 2011/11/08 06:00 [entrez]
PHST- 2011/11/08 06:00 [pubmed]
PHST- 2012/03/30 06:00 [medline]
AID - 10.1111/j.1600-6143.2011.03816.x [doi]
PST - ppublish
SO  - Am J Transplant. 2011 Dec;11(12):2561-8. doi: 10.1111/j.1600-6143.2011.03816.x.
      Epub 2011 Nov 4.


PMID- 22052994
OWN - NLM
STAT- MEDLINE
DCOM- 20120524
LR  - 20220410
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 4
DP  - 2012 Apr
TI  - Development of a research ethics knowledge and analytical skills assessment tool.
PG  - 236-42
LID - 10.1136/medethics-2011-100025 [doi]
AB  - INTRODUCTION: The goal of this project was to develop and validate a new tool to 
      evaluate learners' knowledge and skills related to research ethics. METHODS: A
      core set of 50 questions from existing computer-based online teaching modules
      were identified, refined and supplemented to create a set of 74 multiple-choice, 
      true/false and short answer questions. The questions were pilot-tested and item
      discrimination was calculated for each question. Poorly performing items were
      eliminated or refined. Two comparable assessment tools were created. These
      assessment tools were administered as a pre-test and post-test to a cohort of 58 
      Indian junior health research investigators before and after exposure to a new
      course on research ethics. Half of the investigators were exposed to the course
      online, the other half in person. Item discrimination was calculated for each
      question and Cronbach's alpha for each assessment tool. A final version of the
      assessment tool that incorporated the best questions from the pre-/post-test
      phase was used to assess retention of research ethics knowledge and skills 3
      months after course delivery. RESULTS: The final version of the REKASA includes
      41 items and had a Cronbach's alpha of 0.837. CONCLUSION: The results illustrate,
      in one sample of learners, the successful, systematic development and use of a
      knowledge and skills assessment tool in research ethics capable of not only
      measuring basic knowledge in research ethics and oversight but also assessing
      learners' ability to apply ethics knowledge to the analytical task of reasoning
      through research ethics cases, without reliance on essay or discussion-based
      examination. These promising preliminary findings should be confirmed with
      additional groups of learners.
FAU - Taylor, Holly A
AU  - Taylor HA
AD  - Department of Health Policy and Management, Johns Hopkins Bloomberg School of
      Public Health, Baltimore, MD 21202, USA. htaylor@jhsph.edu
FAU - Kass, Nancy E
AU  - Kass NE
FAU - Ali, Joseph
AU  - Ali J
FAU - Sisson, Stephen
AU  - Sisson S
FAU - Bertram, Amanda
AU  - Bertram A
FAU - Bhan, Anant
AU  - Bhan A
LA  - eng
GR  - U01 AI069497/AI/NIAID NIH HHS/United States
GR  - AIU01069497/PHS HHS/United States
GR  - D43TW000010/TW/FIC NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20111103
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Clinical Competence
MH  - Cohort Studies
MH  - Educational Measurement/*methods
MH  - Ethics, Research/*education
MH  - Humans
MH  - Knowledge
MH  - Program Development/*methods
MH  - Reproducibility of Results
MH  - Research Design
PMC - PMC3801183
MID - NIHMS503147
EDAT- 2011/11/05 06:00
MHDA- 2012/05/25 06:00
CRDT- 2011/11/05 06:00
PHST- 2011/11/05 06:00 [entrez]
PHST- 2011/11/05 06:00 [pubmed]
PHST- 2012/05/25 06:00 [medline]
AID - medethics-2011-100025 [pii]
AID - 10.1136/medethics-2011-100025 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Apr;38(4):236-42. doi: 10.1136/medethics-2011-100025. Epub
      2011 Nov 3.


PMID- 22052659
OWN - NLM
STAT- MEDLINE
DCOM- 20120514
LR  - 20120113
IS  - 1098-1004 (Electronic)
IS  - 1059-7794 (Linking)
VI  - 33
IP  - 2
DP  - 2012 Feb
TI  - Guidelines for establishing locus specific databases.
PG  - 298-305
LID - 10.1002/humu.21646 [doi]
AB  - Information about genetic variation has been collected for some 20 years into
      registries, known as locus specific databases (LSDBs), which nowadays often
      contain information in addition to the actual genetic variation. Several issues
      have to be taken into account when considering establishing and maintaining LSDBs
      and these have been discussed previously in a number of articles describing
      guidelines and recommendations. This information is widely scattered and, for a
      newcomer, it would be difficult to obtain the latest information and guidance.
      Here, a sequence of steps essential for establishing an LSDB is discussed
      together with guidelines for each step. Curators need to collect information from
      various sources, code it in systematic way, and distribute to the research and
      clinical communities. In doing this, ethical issues have to be taken into
      account. To facilitate integration of information to, for example, analyze
      genotype-phenotype correlations, systematic data representation using established
      nomenclatures, data models, and ontologies is essential. LSDB curation and
      maintenance comprises a number of tasks that can be managed by following logical 
      steps. These resources are becoming ever more important and new curators are
      essential to ensure that we will have expertly curated databases for all
      disease-related genes in the near future.
CI  - (c) 2011 Wiley Periodicals, Inc.
FAU - Vihinen, Mauno
AU  - Vihinen M
AD  - Institute of Biomedical Technology, University of Tampere, Finland.
      mauno.vihinen@uta.fi
FAU - den Dunnen, Johan T
AU  - den Dunnen JT
FAU - Dalgleish, Raymond
AU  - Dalgleish R
FAU - Cotton, Richard G H
AU  - Cotton RG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111209
PL  - United States
TA  - Hum Mutat
JT  - Human mutation
JID - 9215429
SB  - IM
MH  - Computational Biology/methods/standards
MH  - Database Management Systems
MH  - Databases, Genetic/ethics/*standards
MH  - Documentation
MH  - Genes
MH  - Genetic Association Studies
MH  - *Genetic Loci
MH  - Guidelines as Topic
MH  - Humans
MH  - Information Dissemination
EDAT- 2011/11/05 06:00
MHDA- 2012/05/15 06:00
CRDT- 2011/11/05 06:00
PHST- 2011/07/25 00:00 [received]
PHST- 2011/10/25 00:00 [accepted]
PHST- 2011/11/05 06:00 [entrez]
PHST- 2011/11/05 06:00 [pubmed]
PHST- 2012/05/15 06:00 [medline]
AID - 10.1002/humu.21646 [doi]
PST - ppublish
SO  - Hum Mutat. 2012 Feb;33(2):298-305. doi: 10.1002/humu.21646. Epub 2011 Dec 9.


PMID- 22052211
OWN - NLM
STAT- MEDLINE
DCOM- 20130123
LR  - 20181201
IS  - 1573-1677 (Electronic)
IS  - 1382-4996 (Linking)
VI  - 17
IP  - 4
DP  - 2012 Oct
TI  - Creating stories to live by: caring and professional identity formation in a
      longitudinal integrated clerkship.
PG  - 585-96
LID - 10.1007/s10459-011-9335-y [doi]
AB  - Building on other models of longitudinal integrated clerkships (LIC), the
      University of Alberta developed its Integrated Community Clerkship with guiding
      principles of continuity of care, preceptor and learning environment.
      Professionalism is an important theme in medical education. Caring is important
      in professional identity formation and an ethic of caring is a moral framework
      for caring. This study explored the development of an ethic of caring in an LIC
      using empathy, compassion and taking responsibility as descriptors of caring.
      Through a hermeneutic phenomenological study, the authors focused on students'
      accounts of being with patients. Following an iterative process of successive
      analyses and explorations of the relevant literature, sensitizing concepts
      related to physician identity, and an ethic of caring were used to make sense of 
      these accounts following the principles of constructivist grounded theory
      methodology. Continuity afforded by the LIC results in a safe environment in
      which students can meaningfully engage with patients and take responsibility for 
      their care under the supervision of a physician teacher. Together these
      attributes foster an emerging physician identity born at the site of
      patient-student interaction and grounded in an ethic of caring. A medical
      student's evolving professional identity in the clerkship includes the emergence 
      of an ethic of caring. Student accounts of being with patients demonstrate that
      the LIC at the University of Alberta affords opportunities for students be
      receptive to and responsible for their patients. This ethic of caring is part of 
      an emerging physician identity for the study participants.
FAU - Konkin, Jill
AU  - Konkin J
AD  - Division of Community Engagement, Department of Family Medicine, Faculty of
      Medicine and Dentistry, University of Alberta, 2-115 Edmonton Clinic Health
      Academy, Edmonton, AB T6G 2C9, Canada. jill.konkin@ualberta.ca
FAU - Suddards, Carol
AU  - Suddards C
LA  - eng
PT  - Journal Article
DEP - 20111104
PL  - Netherlands
TA  - Adv Health Sci Educ Theory Pract
JT  - Advances in health sciences education : theory and practice
JID - 9612021
SB  - IM
CIN - Adv Health Sci Educ Theory Pract. 2013 Mar;18(1):135-8. PMID: 23114458
CIN - Adv Health Sci Educ Theory Pract. 2013 Mar;18(1):139-40. PMID: 23114459
MH  - Alberta
MH  - Clinical Clerkship/*organization & administration/standards
MH  - *Continuity of Patient Care
MH  - Education, Medical, Undergraduate/organization & administration/standards
MH  - Empathy
MH  - Family Practice/*education
MH  - Humans
MH  - Physician-Patient Relations
MH  - Preceptorship/*organization & administration/standards
MH  - Rural Health Services/organization & administration/standards
MH  - Social Responsibility
MH  - Students, Medical/*psychology
MH  - Time Factors
MH  - Workforce
EDAT- 2011/11/05 06:00
MHDA- 2013/01/24 06:00
CRDT- 2011/11/05 06:00
PHST- 2011/05/02 00:00 [received]
PHST- 2011/10/24 00:00 [accepted]
PHST- 2011/11/05 06:00 [entrez]
PHST- 2011/11/05 06:00 [pubmed]
PHST- 2013/01/24 06:00 [medline]
AID - 10.1007/s10459-011-9335-y [doi]
PST - ppublish
SO  - Adv Health Sci Educ Theory Pract. 2012 Oct;17(4):585-96. doi:
      10.1007/s10459-011-9335-y. Epub 2011 Nov 4.


PMID- 22051717
OWN - NLM
STAT- MEDLINE
DCOM- 20120305
LR  - 20111104
IS  - 0717-6163 (Electronic)
IS  - 0034-9887 (Linking)
VI  - 139
IP  - 5
DP  - 2011 May
TI  - [Euthanasia and medical act].
PG  - 642-54
LID - /S0034-98872011000500013 [doi]
AB  - Right to life -as the prohibition of intentionally and arbitrarily taking life,
      even with authorization of the concerned one- is an internationally recognized
      right. In many countries, debate regarding euthanasia is more centered in its
      convenience, social acceptability and how it is regulated, than in its
      substantial legitimacy. Some argue that euthanasia should be included as part of 
      clinical practice of health professionals, grounded on individual's autonomy
      claims-everyone having the liberty to choose how to live and how to die. Against 
      this, others sustain that life has a higher value than autonomy, exercising
      autonomy without respecting the right to life would become a serious moral and
      social problem. Likewise, euthanasia supporters some-times claim a 'right to live
      with dignity', which must be understood as a personal obligation, referred more
      to the ethical than to the strictly legal sphere. In countries where it is
      already legalized, euthanasia practice has extended to cases where it is not the 
      patient who requests this but the family or some healthcare professional, or even
      the legal system-when they think that the patient is living in a condition which 
      is not worthy to live. Generalization of euthanasia possibly will end in
      affecting those who need more care, such as elder, chronically ill or dying
      people, damaging severely personal basic rights. Nature, purpose and tradition of
      medicine rule out the practice of euthanasia, which ought not be considered a
      medical act or legitimately compulsory for physicians. Today's medicine counts
      with effective treatments for pain and suffering, such as palliative care,
      including sedative therapy, which best preserves persons dignity and keeps safe
      the ethos of the medical profession.
CN  - Grupo de Estudios de Etica Clinica de la Sociedad Medica de Santiago
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Eutanasia y acto medico.
DEP - 20110916
PL  - Chile
TA  - Rev Med Chil
JT  - Revista medica de Chile
JID - 0404312
SB  - IM
MH  - Bioethical Issues
MH  - *Ethics, Medical
MH  - *Euthanasia/ethics/legislation & jurisprudence
MH  - Humans
MH  - Palliative Care
MH  - *Personal Autonomy
MH  - *Right to Die/ethics
MH  - Terminology as Topic
MH  - Value of Life
IR  - B CE
FIR - B, Carlos Echeverria
IR  - G AG
FIR - G, Alejandro Goic
IR  - C CH
FIR - C, Carolina Herrera
IR  - V CQ
FIR - V, Carlos Quintana
IR  - O AR
FIR - O, Alberto Rojas
IR  - R RS
FIR - R, Rodrigo Salinas
IR  - M AS
FIR - M, Alejandro Serani
IR  - R PT
FIR - R, Paulina Taboada
IR  - Y RV
FIR - Y, Ricardo Vacarezza
EDAT- 2011/11/05 06:00
MHDA- 2012/03/06 06:00
CRDT- 2011/11/05 06:00
PHST- 2011/11/05 06:00 [entrez]
PHST- 2011/11/05 06:00 [pubmed]
PHST- 2012/03/06 06:00 [medline]
AID - S0034-98872011000500013 [pii]
AID - /S0034-98872011000500013 [doi]
PST - ppublish
SO  - Rev Med Chil. 2011 May;139(5):642-54. doi: /S0034-98872011000500013. Epub 2011
      Sep 16.


PMID- 22051396
OWN - NLM
STAT- MEDLINE
DCOM- 20120221
LR  - 20131121
IS  - 1558-1969 (Electronic)
IS  - 0749-0712 (Linking)
VI  - 27
IP  - 4
DP  - 2011 Nov
TI  - Ethical, financial, and policy considerations in hand transplantation.
PG  - 553-60, xi
LID - 10.1016/j.hcl.2011.07.006 [doi]
AB  - Currently, more than 65 hand transplants have been performed with studies
      demonstrating favorable cosmetic and functional outcomes and cortical
      reintegration of the transplanted hand. Due to such favorable outcomes, many view
      hand transplant as a potential gold standard for treatment of a double amputee.
      However, ethical debate continues regarding risks and benefits of this
      nonlifesaving procedure. Clinicians, patients, and society must agree on whether 
      hand transplantation is ethical and affordable. If a decision is made to
      transplant a hand, this must be performed in a dedicated center that facilitates 
      integration of multiple specialists, ethicists, pharmacists, and
      rehabilitationists.
CI  - Copyright A(c) 2011 Elsevier Inc. All rights reserved.
FAU - Chang, Jeff
AU  - Chang J
AD  - Division of Plastic and Reconstructive Surgery, Department of Surgery, University
      of Washington, Seattle, WA, USA.
FAU - Mathes, David W
AU  - Mathes DW
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110921
PL  - United States
TA  - Hand Clin
JT  - Hand clinics
JID - 8510415
SB  - IM
MH  - Beneficence
MH  - Ethics, Medical
MH  - *Hand Transplantation
MH  - Humans
MH  - Informed Consent
MH  - Organ Transplantation/economics/ethics
MH  - Paternalism
MH  - Personal Autonomy
MH  - Quality of Life
MH  - Risk Assessment
EDAT- 2011/11/05 06:00
MHDA- 2012/02/22 06:00
CRDT- 2011/11/05 06:00
PHST- 2011/11/05 06:00 [entrez]
PHST- 2011/11/05 06:00 [pubmed]
PHST- 2012/02/22 06:00 [medline]
AID - S0749-0712(11)00065-5 [pii]
AID - 10.1016/j.hcl.2011.07.006 [doi]
PST - ppublish
SO  - Hand Clin. 2011 Nov;27(4):553-60, xi. doi: 10.1016/j.hcl.2011.07.006. Epub 2011
      Sep 21.


PMID- 22051226
OWN - NLM
STAT- MEDLINE
DCOM- 20120329
LR  - 20111129
IS  - 1600-6143 (Electronic)
IS  - 1600-6135 (Linking)
VI  - 11
IP  - 12
DP  - 2011 Dec
TI  - The challenge of informed consent for increased risk living donation and
      transplantation.
PG  - 2569-74
LID - 10.1111/j.1600-6143.2011.03814.x [doi]
AB  - The Organ Procurement and Transplantation Network (OPTN) mandates that organ
      recipients provide "specific informed consent" before accepting organs that the
      OPTN defines as "increased risk". However, the OPTN does not provide specific
      guidelines for what information should be disclosed to potential recipients. Such
      vagueness opens the door to inadequate informed consent. This paper examines the 
      ethical dimensions of informed consent when the prospective living donor has
      self-reported behaviors associated with increased risk for infection
      transmission. Donor privacy is a primary ethical concern that conflicts with
      recipients' informed consent for use of increased risk organs. We propose that
      both the increased risk status and the specific behavior be disclosed to the
      recipient. Because the actual risk posed is linked to the type of risk behavior, 
      disclosure is therefore needed to make an informed decision. The donor's risk
      behavior is material to recipients' decision making because it may impact the
      donor-recipient relationship. This relationship is the foundation of the donation
      and acceptance transaction, and thus comprises a critical feature of the
      recipient's informed consent. Optimizing a recipient's informed consent is
      essential to protecting patient safety and autonomy.
CI  - (c)Copyright 2011 The American Society of Transplantation and the American
      Society of Transplant Surgeons.
FAU - Gordon, E J
AU  - Gordon EJ
AD  - Institute for Healthcare Studies, Comprehensive Transplant Center, Feinberg
      School of Medicine, Northwestern University, Chicago, IL, USA.
      e-gordon@northwestern.edu
FAU - Beauvais, N
AU  - Beauvais N
FAU - Theodoropoulos, N
AU  - Theodoropoulos N
FAU - Hanneman, J
AU  - Hanneman J
FAU - McNatt, G
AU  - McNatt G
FAU - Penrod, D
AU  - Penrod D
FAU - Jensen, S
AU  - Jensen S
FAU - Franklin, J
AU  - Franklin J
FAU - Sherman, L
AU  - Sherman L
FAU - Ison, M G
AU  - Ison MG
LA  - eng
PT  - Journal Article
DEP - 20111102
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
SB  - IM
MH  - Decision Making
MH  - Humans
MH  - Informed Consent/*ethics/*psychology
MH  - Living Donors/*ethics/*psychology
MH  - *Organ Transplantation
MH  - Risk Factors
MH  - Tissue and Organ Procurement/*ethics
EDAT- 2011/11/05 06:00
MHDA- 2012/03/30 06:00
CRDT- 2011/11/05 06:00
PHST- 2011/11/05 06:00 [entrez]
PHST- 2011/11/05 06:00 [pubmed]
PHST- 2012/03/30 06:00 [medline]
AID - 10.1111/j.1600-6143.2011.03814.x [doi]
PST - ppublish
SO  - Am J Transplant. 2011 Dec;11(12):2569-74. doi: 10.1111/j.1600-6143.2011.03814.x. 
      Epub 2011 Nov 2.


PMID- 22050646
OWN - NLM
STAT- MEDLINE
DCOM- 20121018
LR  - 20220409
IS  - 1440-1800 (Electronic)
IS  - 1320-7881 (Linking)
VI  - 19
IP  - 3
DP  - 2012 Sep
TI  - Trust and trustworthiness in nursing: an argument-based literature review.
PG  - 223-37
LID - 10.1111/j.1440-1800.2011.00582.x [doi]
AB  - Caring requires nurses to establish trusting relationships with patients and to
      be trustworthy professionals. This article provides insight into the conceptual
      understanding of trust and trustworthiness in nursing through an argument-based
      literature review of 17 articles published between 1980 and 2010. Trust is
      characterized as an attitude relying with confidence on someone. The importance
      of trust relationships is considered by addressing the imbalances of power in
      nurse-patient relationships as they increase the vulnerability and dependency of 
      the truster. Trust is considered as a process, and time, reliance on others, risk
      and fragility are identified as basic attributes of trust. However,
      trustworthiness is inadequately explored in the nursing ethics literature. Nurse 
      educators have a responsibility to ensure that nurses are equipped with the
      attitudes and knowledge that are needed to establish trusting nurse-patient
      relationships.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Dinc, Leyla
AU  - Dinc L
AD  - Hacettepe University, Ankara, Turkey. leylad@hacettepe.edu.tr
FAU - Gastmans, Chris
AU  - Gastmans C
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111103
PL  - Australia
TA  - Nurs Inq
JT  - Nursing inquiry
JID - 9505881
MH  - Humans
MH  - *Nurse-Patient Relations
MH  - *Trust
EDAT- 2011/11/05 06:00
MHDA- 2012/10/19 06:00
CRDT- 2011/11/05 06:00
PHST- 2011/11/05 06:00 [entrez]
PHST- 2011/11/05 06:00 [pubmed]
PHST- 2012/10/19 06:00 [medline]
AID - 10.1111/j.1440-1800.2011.00582.x [doi]
PST - ppublish
SO  - Nurs Inq. 2012 Sep;19(3):223-37. doi: 10.1111/j.1440-1800.2011.00582.x. Epub 2011
      Nov 3.


PMID- 22050620
OWN - NLM
STAT- MEDLINE
DCOM- 20120222
LR  - 20191210
IS  - 1440-1800 (Electronic)
IS  - 1320-7881 (Linking)
VI  - 18
IP  - 4
DP  - 2011 Dec
TI  - Morbidly obese patients and lifestyle change: constructing ethical selves.
PG  - 348-58
LID - 10.1111/j.1440-1800.2011.00538.x [doi]
AB  - Morbidly obese patients and lifestyle change: constructing ethical selves In
      contemporary societies, bodily size is an important part of individuals'
      self-representation. As the number of persons clinically diagnosed as morbidly
      obese increases, programmes are developed to make people reduce weight by
      changing their lifestyle, and for some, by bariatric surgery. This article
      presents findings from interviews with 12 participants undergoing a prerequisite 
      course prior to bariatric surgery that is intended both as a preparation for
      further (surgical) treatment and as a tool to empower individuals regarding
      lifestyle changes. In this study, we investigate how power operates by looking at
      how the participants position themselves throughout the course. Findings reveal
      how participants construct their ability to act in line with norms of lifestyle
      change. They do this by positioning themselves as both included group members and
      as 'morally' acceptable individuals. Despite some resistance, the participants
      tend to glide into the role of 'good patients' acting in compliance with the aims
      of the course in their hope and striving for new positions as 'normal-sized'. The
      intention in the course is to empower individuals towards lifestyle changes. The 
      findings provide a basis to question whether these kinds of courses create new
      forms of compliance and dependency.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Knutsen, Ingrid Ruud
AU  - Knutsen IR
AD  - Akershus University College, Lillestrom, Norway University of Oslo.
      Ingrid.ruudknutsen@hiak.no
FAU - Terragni, Laura
AU  - Terragni L
FAU - Foss, Christina
AU  - Foss C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110710
PL  - Australia
TA  - Nurs Inq
JT  - Nursing inquiry
JID - 9505881
MH  - Adult
MH  - Bariatric Surgery
MH  - *Bioethical Issues
MH  - Female
MH  - *Health Behavior
MH  - Humans
MH  - *Life Style
MH  - Male
MH  - Mandatory Programs
MH  - Middle Aged
MH  - Norway
MH  - Obesity, Morbid/*psychology/surgery
MH  - *Patient Education as Topic
MH  - *Power, Psychological
MH  - Qualitative Research
EDAT- 2011/11/05 06:00
MHDA- 2012/02/23 06:00
CRDT- 2011/11/05 06:00
PHST- 2011/11/05 06:00 [entrez]
PHST- 2011/11/05 06:00 [pubmed]
PHST- 2012/02/23 06:00 [medline]
AID - 10.1111/j.1440-1800.2011.00538.x [doi]
PST - ppublish
SO  - Nurs Inq. 2011 Dec;18(4):348-58. doi: 10.1111/j.1440-1800.2011.00538.x. Epub 2011
      Jul 10.


PMID- 22050617
OWN - NLM
STAT- MEDLINE
DCOM- 20120222
LR  - 20111104
IS  - 1440-1800 (Electronic)
IS  - 1320-7881 (Linking)
VI  - 18
IP  - 4
DP  - 2011 Dec
TI  - Gender, sexuality and the participatory dimensions of a comparative life history 
      policy study.
PG  - 313-24
LID - 10.1111/j.1440-1800.2011.00524.x [doi]
AB  - Gender, sexuality and the participatory dimensions of a comparative life history 
      policy study In this paper, I explore how a critical feminist lens was a crucial 
      element in creating a participatory policy study which used a qualitative design 
      and comparative life history methodology. This study focused on Canadian nurses' 
      political practice related to advocacy for lesbian health. Findings show that the
      combination of the gender lens and life history approach offers potential to
      create knowledge in ways aligned with health-promoting and emancipatory outcomes.
      However, the nature of participation and interaction by researcher and
      participants is contexualized and contested given complex dynamics of power that 
      shape all aspects of this doctoral study process. The critical feminist lens with
      its focus on reflexivity informed the content and process of knowledge production
      in this study and shaped key turning points: the ways in which this policy study 
      was conceptualized, the choice of comparative life history methodology, ethical
      considerations, data collection and analysis and representation of findings. Life
      history is unlikely to be the methodology that first comes to mind when
      undertaking a policy study. Its historical roots are associated with
      biographical, oral history and narrative approaches, which typically aim to
      elicit understanding of lived experience. Yet, it was this very aspect, this
      focus on lived experience, which rendered life history methodology fitting as I
      contemplated how to examine the relationship between nurses and policy. I was
      interested in understanding nurses' political practice, how policy influenced
      nurses' capacity to advocate in their everyday lives, as well as nurses' impacts 
      on policy processes and their larger social worlds.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Macdonnell, Judith A
AU  - Macdonnell JA
AD  - York University, Toronto, ON, Canada.
LA  - eng
PT  - Journal Article
DEP - 20110710
PL  - Australia
TA  - Nurs Inq
JT  - Nursing inquiry
JID - 9505881
MH  - Canada
MH  - Community-Based Participatory Research
MH  - Female
MH  - *Feminism
MH  - *Health Policy
MH  - *Homosexuality, Female
MH  - Humans
MH  - Life Change Events
MH  - Nurses/*psychology
MH  - Nursing Methodology Research
MH  - *Patient Advocacy
MH  - Qualitative Research
EDAT- 2011/11/05 06:00
MHDA- 2012/02/23 06:00
CRDT- 2011/11/05 06:00
PHST- 2011/11/05 06:00 [entrez]
PHST- 2011/11/05 06:00 [pubmed]
PHST- 2012/02/23 06:00 [medline]
AID - 10.1111/j.1440-1800.2011.00524.x [doi]
PST - ppublish
SO  - Nurs Inq. 2011 Dec;18(4):313-24. doi: 10.1111/j.1440-1800.2011.00524.x. Epub 2011
      Jul 10.


PMID- 22050609
OWN - NLM
STAT- MEDLINE
DCOM- 20130515
LR  - 20211021
IS  - 1365-2648 (Electronic)
IS  - 0309-2402 (Linking)
VI  - 68
IP  - 8
DP  - 2012 Aug
TI  - The attitudes of neonatal nurses towards extremely preterm infants.
PG  - 1768-79
LID - 10.1111/j.1365-2648.2011.05865.x [doi]
AB  - AIM: The paper is a report of a study of the attitudes of neonatal nurses towards
      extremely preterm infants. BACKGROUND: Alongside advancing survival at extremely 
      preterm gestational ages, ethical debates concerning the provision of invasive
      care have proliferated in light of the high morbidity. Despite nurses being the
      healthcare professionals who work closest with the infant and their family, their
      potential influence is usually ignored when determining how parents come to
      decisions about future care for their extremely premature infant. METHODS: A Q
      methodology was employed to explore the attitudes of neonatal nurses towards
      caring for extremely preterm infants. Data were collected between 2007 and 2008
      and analysed using PQMethod and Card Content Analysis. RESULTS: Thirty-six nurses
      from six neonatal units in the United Kingdom participated. Although there was
      consensus around the professional role of the nurse, when faced with the
      complexities of neonatal nursing three distinguishing factors emerged: the
      importance of parental choice in decision-making, the belief that technology
      should be used to assess response to treatment, and the belief that healthcare
      professionals should undertake difficult decisions. CONCLUSION: Neonatal nurses
      report unexpected difficulties in upholding their professionally defined role
      through highly complex and ever varied decision-making processes. Recognition of 
      individual attitudes to the care of extremely preterm infants and the role of the
      family in the face of difficult decisions should facilitate more open
      communication between the nurse and the parents and improve the experience of
      both the nurse and the family during these emotional situations.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Gallagher, Katie
AU  - Gallagher K
AD  - Florence Nightingale School of Nursing and Midwifery, King's College London, UK. 
      katie.gallagher@kcl.ac.uk
FAU - Marlow, Neil
AU  - Marlow N
FAU - Edgley, Alison
AU  - Edgley A
FAU - Porock, Davina
AU  - Porock D
LA  - eng
GR  - G0401525/MRC_/Medical Research Council/United Kingdom
GR  - MR/J01107X/1/MRC_/Medical Research Council/United Kingdom
GR  - RP-DG-0611-10006/DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111103
PL  - England
TA  - J Adv Nurs
JT  - Journal of advanced nursing
JID - 7609811
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - *Decision Making
MH  - Female
MH  - Gestational Age
MH  - Humans
MH  - Infant, Extremely Premature/*psychology
MH  - Infant, Newborn
MH  - Intensive Care, Neonatal/ethics/psychology
MH  - Life Support Care/ethics/psychology
MH  - Male
MH  - Middle Aged
MH  - Neonatal Nursing/*ethics
MH  - Nurse's Role/*psychology
MH  - Nurses/*psychology
MH  - Nursing Research
MH  - Parents/psychology
MH  - Principal Component Analysis
MH  - Professional-Family Relations
MH  - Q-Sort
MH  - United Kingdom
MH  - Young Adult
EDAT- 2011/11/05 06:00
MHDA- 2013/05/17 06:00
CRDT- 2011/11/05 06:00
PHST- 2011/11/05 06:00 [entrez]
PHST- 2011/11/05 06:00 [pubmed]
PHST- 2013/05/17 06:00 [medline]
AID - 10.1111/j.1365-2648.2011.05865.x [doi]
PST - ppublish
SO  - J Adv Nurs. 2012 Aug;68(8):1768-79. doi: 10.1111/j.1365-2648.2011.05865.x. Epub
      2011 Nov 3.


PMID- 22049818
OWN - NLM
STAT- MEDLINE
DCOM- 20111206
LR  - 20190923
IS  - 0035-8665 (Print)
IS  - 0035-8665 (Linking)
VI  - 157
IP  - 3 Suppl 1
DP  - 2011 Sep
TI  - The deployed medical director: managing the challenges of a complex trauma
      system.
PG  - S350-6
AB  - Contemporary combat casualty care has never been more sophisticated or effective,
      which is matched by an unprecedented level of clinical complexity. The management
      of this complexity has demanded the evolution of a more direct clinical
      leadership model in the field hospital: the Deployed Medical Director (DMD). The 
      DMD has a central co-ordinating role in reducing the friction generated by
      individuals' unfamiliarity in a rapidly developing clinical environment that has 
      diverged from the NHS; in cementing interoperability within a multinational
      medical treatment facility working at high intensity; and in maintaining and
      developing the highest clinical standards within the deployed trauma system. This
      article describes the evolution of the DMD role and illustrates the challenges
      through a series of vignettes. Particular emphasis is given to the organisational
      risk that the role carries through necessary ethical choices, the requirement to 
      integrate multi-national cultural differences and the challenge of dealing with
      interpersonal frictions amongst senior staff.
FAU - Mahoney, P F
AU  - Mahoney PF
AD  - University of Birmingham. PROF.DMACC@rcdm.bham.ac.uk
FAU - Hodgetts, T J
AU  - Hodgetts TJ
FAU - Hicks, I
AU  - Hicks I
LA  - eng
PT  - Journal Article
PL  - England
TA  - J R Army Med Corps
JT  - Journal of the Royal Army Medical Corps
JID - 7505627
SB  - IM
CIN - J R Army Med Corps. 2012 Mar;158(1):66. PMID: 22545379
MH  - England
MH  - Ethics, Medical
MH  - Humans
MH  - Interpersonal Relations
MH  - *Physician Executives
MH  - Role
MH  - United States
MH  - Warfare
MH  - Wounds and Injuries/*therapy
EDAT- 2011/11/05 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/11/05 06:00
PHST- 2011/11/05 06:00 [entrez]
PHST- 2011/11/05 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1136/jramc-157-03s-15 [doi]
PST - ppublish
SO  - J R Army Med Corps. 2011 Sep;157(3 Suppl 1):S350-6. doi:
      10.1136/jramc-157-03s-15.


PMID- 22049167
OWN - NLM
STAT- MEDLINE
DCOM- 20120213
LR  - 20161125
IS  - 1938-3207 (Electronic)
IS  - 0002-9165 (Linking)
VI  - 94
IP  - 6 Suppl
DP  - 2011 Dec
TI  - Coevolution of nutrigenomics and society: ethical considerations.
PG  - 2025S-2029S
LID - 10.3945/ajcn.110.001289 [doi]
AB  - To optimize the coevolution of nutrigenomics and society (ie, the reciprocal
      stimulation of both developments), I analyzed chances for a fruitful match
      between normative concepts and strategies of both developments. Nutrigenomics
      embodies >/= 3 normative concepts. First, food is exclusively interpreted in
      terms of disease prevention. Second, striving for health is interpreted as the
      quantification of risks and prevention of diseases through positive food-gene
      interactions. The third normative idea is that disease prevention by the
      minimization of risks is an individual's task. My thesis was that these concepts 
      of nutrigenomics would not easily match with concepts of food and health of
      various food styles in Western societies, which, for instance, parents in the
      case of metabolic programming endorse and with a philosophical view of the
      relation between food, health, and the meaning of life. Next, I reflected on the 
      nonsynchronized coevolution of nutrigenomics and society because of this mismatch
      and introduced the concept of the fair representation of food styles in
      nutrigenomic developments. To synchronize and optimize the coevolution of
      nutrigenomics and society, I propose that the research policy of nutrigenomics
      should change to a research partnership with society on the basis of fair
      representation.
FAU - Korthals, Michiel
AU  - Korthals M
AD  - Social Sciences Group, Wageningen University, Wageningen, Netherlands.
      michiel.korthals@wur.nl
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111102
PL  - United States
TA  - Am J Clin Nutr
JT  - The American journal of clinical nutrition
JID - 0376027
SB  - IM
MH  - Diet
MH  - *Feeding Behavior
MH  - Food
MH  - Food Preferences
MH  - Food, Organic
MH  - *Health Status
MH  - Humans
MH  - Life Style
MH  - Nutrigenomics/*ethics/*standards
MH  - Nutrition Policy
MH  - Nutritional Physiological Phenomena
EDAT- 2011/11/04 06:00
MHDA- 2012/02/14 06:00
CRDT- 2011/11/04 06:00
PHST- 2011/11/04 06:00 [entrez]
PHST- 2011/11/04 06:00 [pubmed]
PHST- 2012/02/14 06:00 [medline]
AID - ajcn.110.001289 [pii]
AID - 10.3945/ajcn.110.001289 [doi]
PST - ppublish
SO  - Am J Clin Nutr. 2011 Dec;94(6 Suppl):2025S-2029S. doi: 10.3945/ajcn.110.001289.
      Epub 2011 Nov 2.


PMID- 22049088
OWN - NLM
STAT- MEDLINE
DCOM- 20120724
LR  - 20120215
IS  - 1740-7753 (Electronic)
IS  - 1740-7745 (Linking)
VI  - 9
IP  - 1
DP  - 2012 Feb
TI  - Transparency in the presentation of trial results may not increase patients'
      trust in medical researchers.
PG  - 90-3
LID - 10.1177/1740774511427063 [doi]
AB  - BACKGROUND: One of the expected benefits of sharing trial results with
      participants is that it may enhance trust in medical researchers (TMRs). PURPOSE:
      In a prospective study on a sample of clinical trial participants, we
      investigated the effect on the participants' TMRs of providing final trial
      results to participants via the Internet. METHODS: Participants in the
      FNCLCC-PACS04 trial (ClinicalTrials.gov Identifier: NCT00054587) were surveyed on
      average 6 years after enrollment, when the trial results were available. In the
      current study, they were randomized to receive (experimental group) or not to
      receive (control group) a letter informing them that the results of the trial
      could be consulted on a specific website. TMRs was measured before randomization 
      and 6 months later using mailed self-administered questionnaires. RESULTS: The
      response rate was 93% (N = 107). TMRs remained unchanged in the control group
      (mean effect size = -0.06, 95% confidence interval (CI): -0.28 to 0.17, p =
      0.617) but decreased in the experimental group (-0.30, 95% CI: -0.53 to -0.06, p 
      = 0.015). However, the difference between the two effect sizes was not
      statistically significant (p = 0.144). LIMITATIONS: The results obtained here on 
      the disclosure of final trial results to breast cancer patients via the Internet 
      cannot be generalized to all situations involving the disclosure of phase III
      randomized controlled trial results. CONCLUSIONS: Transparency is an ethical
      research requirement, but it may not enhance participants' TMRs.
FAU - Mancini, Julien
AU  - Mancini J
AD  - Aix-Marseille Univ, Marseille, F-13385 France. julien.mancini@univmed.fr
FAU - Genre, Dominique
AU  - Genre D
FAU - Dalenc, Florence
AU  - Dalenc F
FAU - Maylevin, Francoise
AU  - Maylevin F
FAU - Martin, Anne-Laure
AU  - Martin AL
FAU - Viens, Patrice
AU  - Viens P
FAU - Julian-Reynier, Claire
AU  - Julian-Reynier C
LA  - eng
SI  - ClinicalTrials.gov/NCT00054587
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20111102
PL  - England
TA  - Clin Trials
JT  - Clinical trials (London, England)
JID - 101197451
SB  - IM
MH  - Disclosure/*ethics
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Patients/*psychology
MH  - Prospective Studies
MH  - Randomized Controlled Trials as Topic/*ethics
MH  - Research Personnel/*ethics
MH  - *Trust
EDAT- 2011/11/04 06:00
MHDA- 2012/07/25 06:00
CRDT- 2011/11/04 06:00
PHST- 2011/11/04 06:00 [entrez]
PHST- 2011/11/04 06:00 [pubmed]
PHST- 2012/07/25 06:00 [medline]
AID - 1740774511427063 [pii]
AID - 10.1177/1740774511427063 [doi]
PST - ppublish
SO  - Clin Trials. 2012 Feb;9(1):90-3. doi: 10.1177/1740774511427063. Epub 2011 Nov 2.


PMID- 22048853
OWN - NLM
STAT- MEDLINE
DCOM- 20120524
LR  - 20211021
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 4
DP  - 2012 Apr
TI  - In the lion's den? Experiences of interaction with research ethics committees.
PG  - 224-7
LID - 10.1136/medethics-2011-100124 [doi]
AB  - Research ethics review is an important process, designed to protect participants 
      in medical research. However, it is increasingly criticised for failing to meet
      its aims. Here, two researchers reflect on their experiences of applying for
      ethical approval of observational research in clinical settings. They highlight
      some problems faced by reviewers and researchers and propose a two-stage ethical 
      review process that would alert researchers to the committee's concerns and allow
      them to give a more considered response.
FAU - Fistein, Elizabeth
AU  - Fistein E
AD  - General Practice Education Group, Institute of Public Health, University of
      Cambridge, Cambridge, UK. ecf22@medschl.cam.ac.uk
FAU - Quilligan, Sally
AU  - Quilligan S
LA  - eng
PT  - Journal Article
DEP - 20111102
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Biomedical Research/ethics/standards
MH  - Ethics Committees, Research/legislation & jurisprudence/*organization &
      administration/*standards
MH  - Humans
MH  - Research Personnel/education/*psychology
PMC - PMC3311868
EDAT- 2011/11/04 06:00
MHDA- 2012/05/25 06:00
CRDT- 2011/11/04 06:00
PHST- 2011/11/04 06:00 [entrez]
PHST- 2011/11/04 06:00 [pubmed]
PHST- 2012/05/25 06:00 [medline]
AID - medethics-2011-100124 [pii]
AID - 10.1136/medethics-2011-100124 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Apr;38(4):224-7. doi: 10.1136/medethics-2011-100124. Epub 2011
      Nov 2.


PMID- 22048851
OWN - NLM
STAT- MEDLINE
DCOM- 20120524
LR  - 20191210
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 4
DP  - 2012 Apr
TI  - The principle of parity: the 'placebo effect' and physician communication.
PG  - 199-203
LID - 10.1136/medethics-2011-100177 [doi]
AB  - The use of 'placebos' in clinical practice is a source of continued controversy
      for physicians and medical ethicists. There is rarely any extensive discussion on
      what 'placebos' are and how they work. In this paper, drawing on Louhiala and
      Puustinen's work, the author proposes that the term 'placebo effect' be replaced 
      in clinical contexts with the term 'positive care effect'. Medical treatment
      always takes place in a 'context of care' that encompasses all the phenomena
      associated with medical intervention it includes the particular method of
      treatment, the interpersonal relationships between medical staff and the patient 
      and other factors, including physicians' and patients' beliefs in the power of
      the treatment. Together, these phenomena can result in a full spectrum of
      therapeutic effects to the patient--from no effects, to small effects, to large
      effects. In cases where there are significant therapeutic benefits to the
      patient, 'positive care effects' may be spoken of. Since the ethical codes of the
      General Medical Council and the American Medical Association demand transparency 
      with respect to patient treatment and insist on complete openness in 'placebo'
      usage, the author argues that, as a matter of conceptual rigour and consistency, 
      if the term 'placebo effect' is replaced by 'positive care effect', these ethical
      codes appear to insist on transparency about all such beneficial components of
      treatment. Given that this appears to be a counterintuitive obligation, the
      author concludes the paper with some comments on the clinical consequences of
      this conceptual revision, including a brief discussion of how this important
      debate might develop.
FAU - Blease, Charlotte
AU  - Blease C
AD  - School of Politics, International Studies and Philosophy, Queen's University, 21 
      University Square, BT9 6TQ Belfast, UK. cblease02@qub.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20111102
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Attitude of Health Personnel
MH  - Communication
MH  - Female
MH  - Humans
MH  - Linguistics
MH  - Mind-Body Relations, Metaphysical
MH  - Outcome Assessment, Health Care
MH  - *Physician-Patient Relations
MH  - *Placebo Effect
EDAT- 2011/11/04 06:00
MHDA- 2012/05/25 06:00
CRDT- 2011/11/04 06:00
PHST- 2011/11/04 06:00 [entrez]
PHST- 2011/11/04 06:00 [pubmed]
PHST- 2012/05/25 06:00 [medline]
AID - medethics-2011-100177 [pii]
AID - 10.1136/medethics-2011-100177 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Apr;38(4):199-203. doi: 10.1136/medethics-2011-100177. Epub
      2011 Nov 2.


PMID- 22048850
OWN - NLM
STAT- MEDLINE
DCOM- 20120524
LR  - 20131121
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 4
DP  - 2012 Apr
TI  - Psychotropic drugs and paediatrics: a critical need for more clinical trials.
PG  - 250-2
LID - 10.1136/medethics-2011-100003 [doi]
AB  - Many children in the USA are prescribed psychotropic drugs that have not been
      fully investigated in paediatric clinical trials. The common practice of
      prescribing psychotropic drugs off-label poses unknown and potentially serious
      short- and long-term consequences for these children. This paper briefly reviews 
      the factors associated with the lack of paediatric clinical trials. We advocate a
      shift toward increasing paediatric trials with psychotropic drugs through a
      combination of adequate safety controls, additional reimbursement/compensation, a
      more organised and large-scale effort to collate results and outcomes across
      researchers and studies and additional public education about the importance of
      this research. In addition, we encourage the re-examination of the ethical
      standards for children's participation in phase 1 clinical trials as well as
      argue for longitudinal developmental studies on children who are prescribed
      off-label psychotropic drugs.
FAU - Tishler, Carl L
AU  - Tishler CL
AD  - Department Psychology, The Ohio State University, Columbus, OH 43203, USA.
      tishler.1@osu.edu
FAU - Reiss, Natalie S
AU  - Reiss NS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20111102
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
RN  - 0 (Psychotropic Drugs)
SB  - IM
MH  - Child
MH  - Clinical Trials as Topic/methods/statistics & numerical data
MH  - Drug Labeling
MH  - Drug-Related Side Effects and Adverse Reactions
MH  - Humans
MH  - Mental Disorders/*drug therapy
MH  - Pediatrics/*ethics/*methods
MH  - Psychotropic Drugs/*adverse effects/*therapeutic use
MH  - Treatment Outcome
EDAT- 2011/11/04 06:00
MHDA- 2012/05/25 06:00
CRDT- 2011/11/04 06:00
PHST- 2011/11/04 06:00 [entrez]
PHST- 2011/11/04 06:00 [pubmed]
PHST- 2012/05/25 06:00 [medline]
AID - medethics-2011-100003 [pii]
AID - 10.1136/medethics-2011-100003 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Apr;38(4):250-2. doi: 10.1136/medethics-2011-100003. Epub 2011
      Nov 2.


PMID- 22048504
OWN - NLM
STAT- MEDLINE
DCOM- 20131209
LR  - 20211020
IS  - 0975-4466 (Electronic)
IS  - 0256-4947 (Linking)
VI  - 31
IP  - 6
DP  - 2011 Nov-Dec
TI  - Home caregivers' satisfaction with the services provided by Riyadh Military
      Hospital's home support program.
PG  - 591-7
LID - 10.4103/0256-4947.87095 [doi]
AB  - BACKGROUND AND OBJECTIVES: The satisfaction of the family is essential to the
      success of home care support services. This study aimed to assess home
      caregivers' satisfaction with support services and to identify potential factors 
      affecting their satisfaction. DESIGN AND SETTINGS: The study was conducted in the
      Family and Community Medicine Department at Riyadh Military Hospital using
      cross-sectional design over a period of six months. PATIENTS AND METHODS: Two
      hundred forty participants were recruited by systematic random sampling from the 
      division registry. Data were collected through telephone calls using a designed
      structured interview form. All research ethics principles were followed. RESULTS:
      The response rate was 76.25%. Most caregivers were patients' sons or daughters.
      The duration of patients' disabling illnesses varied from less than 1 year to up 
      to 40 years. The majority of caregivers agreed that a home care services team
      provided the proper healthcare-related support to the patients and improved
      caregivers' self-confidence in caring for their patients. Overall, on a scale of 
      100%, the median level of satisfaction was 90%, and 73.2% of caregivers had a
      satisfaction score of 75% or higher. Increased age, female gender, and more
      frequent home visits were positive independent factors associated with
      caregivers' satisfaction scores. CONCLUSION: Although most caregivers are
      satisfied with the services provided by a home care support program, there are
      still areas of deficiency, particularly in physiotherapy, vocational therapy, and
      social services. The implications are that caregivers need to be educated and
      trained in caring for their patients and need to gain self-confidence in their
      skills. The program's administration should improve physiotherapy, vocational
      therapy, social services, and procedures for hospital referral.
FAU - Al-Khashan, Hesham
AU  - Al-Khashan H
AD  - Department of Family and Community Medicine, Riyadh Military Hospital, Riyadh,
      Saudi Arabia.
FAU - Mishriky, Adel
AU  - Mishriky A
FAU - Selim, Mohei
AU  - Selim M
FAU - El Sheikh, Abdalla
AU  - El Sheikh A
FAU - BinSaeed, Abdulaziz A
AU  - BinSaeed AA
LA  - eng
PT  - Journal Article
PL  - Saudi Arabia
TA  - Ann Saudi Med
JT  - Annals of Saudi medicine
JID - 8507355
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Caregivers/classification/psychology
MH  - Consumer Behavior/*statistics & numerical data
MH  - Disabled Persons/*rehabilitation
MH  - Female
MH  - Home Care Services, Hospital-Based/*standards
MH  - Hospitals, Military
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Program Evaluation
MH  - Quality Improvement
MH  - Saudi Arabia
MH  - Self Efficacy
MH  - Social Support
MH  - Surveys and Questionnaires
PMC - PMC3221130
EDAT- 2011/11/04 06:00
MHDA- 2013/12/16 06:00
CRDT- 2011/11/04 06:00
PHST- 2011/11/04 06:00 [entrez]
PHST- 2011/11/04 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - AnnSaudiMed_2011_31_6_591_87095 [pii]
AID - 10.4103/0256-4947.87095 [doi]
PST - ppublish
SO  - Ann Saudi Med. 2011 Nov-Dec;31(6):591-7. doi: 10.4103/0256-4947.87095.


PMID- 22048444
OWN - NLM
STAT- MEDLINE
DCOM- 20111215
LR  - 20111103
IS  - 1827-6806 (Print)
IS  - 1827-6806 (Linking)
VI  - 12
IP  - 11
DP  - 2011 Nov
TI  - [Preparticipation electrocardiographic screening for the prevention of sudden
      death in sports medicine].
PG  - 697-706
LID - 10.1714/966.10541 [doi]
AB  - Both the American Heart Association and the European Society of Cardiology
      consensus panel recommendations agree that cardiovascular screening for young
      competitive athletes is justifiable and compelling on ethical, legal, and medical
      grounds. However, there is a considerable discordance in the consensus guidelines
      on the pre-participation screening protocols used among European and US
      cardiologists/sports medicine physicians, with and without 12-lead
      electrocardiogram (ECG). In 1982 a nationwide program of pre-participation
      screening including ECG was launched in Italy. The aim of this article is to
      examine whether this long-running screening program should be considered a valid 
      and advisable public health strategy. The analysis of data coming from the
      Italian experience indicates that ECG screening has provided adequate sensitivity
      and specificity for detection of potentially lethal cardiomyopathy or arrhythmias
      and has led to substantial reduction of mortality of young competitive athletes
      by approximately 90%. Screening has been feasible thanks to the Italian Health
      System, which is developed in terms of healthcare and prevention services, and
      because of the limited costs of cardiovascular evaluation in the setting of a
      mass program. The available scientific evidence suggests to adopt a screening
      protocol including ECG, which is the only screening tool proved to be effective. 
      This article will also address the available data and criticisms concerning the
      screening program to prevent sudden cardiac death of middle-aged/senior athletes 
      engaged in leisure-time sports activity.
FAU - Corrado, Domenico
AU  - Corrado D
AD  - Dipartimento di Scienze Cardiologiche, Toraciche e Vasoclari, Universita degli
      Studi, Paova. domenico.corrado@unipd.it
FAU - Migliore, Federico
AU  - Migliore F
FAU - Zorzi, Alessandro
AU  - Zorzi A
FAU - Siciliano, Mariachiara
AU  - Siciliano M
FAU - Basso, Cristina
AU  - Basso C
FAU - Schiavon, Maurizio
AU  - Schiavon M
FAU - Thiene, Gaetano
AU  - Thiene G
LA  - ita
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
TT  - L'importanza dell'elettrocardiogramma nella visita medico-sportiva per ridurre il
      rischio di morte improvvisa.
PL  - Italy
TA  - G Ital Cardiol (Rome)
JT  - Giornale italiano di cardiologia (2006)
JID - 101263411
SB  - IM
MH  - Death, Sudden, Cardiac/*prevention & control
MH  - Decision Trees
MH  - *Electrocardiography
MH  - Humans
MH  - Sensitivity and Specificity
MH  - *Sports
EDAT- 2011/11/04 06:00
MHDA- 2011/12/16 06:00
CRDT- 2011/11/04 06:00
PHST- 2011/11/04 06:00 [entrez]
PHST- 2011/11/04 06:00 [pubmed]
PHST- 2011/12/16 06:00 [medline]
AID - 10.1714/966.10541 [doi]
PST - ppublish
SO  - G Ital Cardiol (Rome). 2011 Nov;12(11):697-706. doi: 10.1714/966.10541.


PMID- 22048283
OWN - NLM
STAT- MEDLINE
DCOM- 20120614
LR  - 20220408
IS  - 1438-8359 (Electronic)
IS  - 0913-8668 (Linking)
VI  - 26
IP  - 1
DP  - 2012 Feb
TI  - Passiflora incarnata Linneaus as an anxiolytic before spinal anesthesia.
PG  - 39-44
LID - 10.1007/s00540-011-1265-6 [doi]
AB  - PURPOSE: Patients who undergo regional anesthesia experience anxiety in the
      preoperative period. Passiflora incarnata Linneaus is a plant that has
      traditionally been used as an anxiolytic and sedative. We aimed to investigate
      the effect of preoperative oral administration of Passiflora incarnata Linneaus
      on anxiety, psychomotor functions, sedation, and hemodynamics in patients
      undergoing spinal anesthesia. METHODS: Under local ethics committee approval, 60 
      patients who were aged 25-55 years and ASAI-II and who were scheduled for spinal 
      anesthesia were enrolled in this prospective, randomized, double-blind and
      placebo-controlled study. Thirty minutes before spinal anesthesia, baseline
      hemodynamic parameters, State-Trait Anxiety Inventory (STAI) score, sedation
      score, and psychomotor function test results were measured, then patients were
      randomly assigned to two groups: oral Passiflora incarnata Linneaus extract or
      placebo was given to the patients. Tests were repeated just before spinal
      anesthesia. Hemodynamics, sedation score, sensory-motor block and side effects
      were assessed during the operation. Psychomotor function tests were repeated at
      the end of the operation and 60 min after the operation. RESULTS: There was a
      statistically significant difference between the two groups for the increase in
      State Anxiety Inventory (STAI-S) score obtained just before spinal anesthesia
      when compared to the baseline. There was no statistically significant difference 
      in psychomotor function from the baseline for either group. A significant
      difference was not found between the two groups in demographics, psychomotor
      function, sedation score, hemodynamics, and side effects. CONCLUSION: Oral
      preoperative administration of Passiflora incarnata Linneaus suppresses the
      increase in anxiety before spinal anesthesia without changing psychomotor
      function test results, sedation level, or hemodynamics.
FAU - Aslanargun, Pinar
AU  - Aslanargun P
AD  - Department of Anesthesiology and Intensive Care Medicine, Ankara Training and
      Research Hospital, Ankara, Turkey.
FAU - Cuvas, Ozgun
AU  - Cuvas O
FAU - Dikmen, Bayazit
AU  - Dikmen B
FAU - Aslan, Eymen
AU  - Aslan E
FAU - Yuksel, Mustafa Ugur
AU  - Yuksel MU
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20111103
PL  - Japan
TA  - J Anesth
JT  - Journal of anesthesia
JID - 8905667
RN  - 0 (Anti-Anxiety Agents)
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Adult
MH  - *Anesthesia, Spinal
MH  - Anti-Anxiety Agents/*therapeutic use
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Passiflora
MH  - *Phytotherapy
MH  - Plant Extracts/*therapeutic use
MH  - *Preanesthetic Medication
MH  - Prospective Studies
EDAT- 2011/11/04 06:00
MHDA- 2012/06/15 06:00
CRDT- 2011/11/04 06:00
PHST- 2011/02/26 00:00 [received]
PHST- 2011/10/12 00:00 [accepted]
PHST- 2011/11/04 06:00 [entrez]
PHST- 2011/11/04 06:00 [pubmed]
PHST- 2012/06/15 06:00 [medline]
AID - 10.1007/s00540-011-1265-6 [doi]
PST - ppublish
SO  - J Anesth. 2012 Feb;26(1):39-44. doi: 10.1007/s00540-011-1265-6. Epub 2011 Nov 3.


PMID- 22047471
OWN - NLM
STAT- MEDLINE
DCOM- 20120924
LR  - 20120525
IS  - 1532-5040 (Electronic)
IS  - 0959-3985 (Linking)
VI  - 28
IP  - 4
DP  - 2012 May
TI  - From idealistic helper to enterprising learner: critical reflections on personal 
      development through experiences from Afghanistan.
PG  - 283-91
LID - 10.3109/09593985.2011.608114 [doi]
AB  - There is little written about the cultural, social, and ethical challenges
      encountered by physiotherapists engaging in development work. This article takes 
      a critical perspective on what it means to engage in development work as an
      expatriate physiotherapist, through a self-critical reflection on experiences
      from Afghanistan. The field notes from an ethnographic study of a development
      project conducted in Afghanistan were analysed to explore the transformative
      process of personal and professional development of the development worker. The
      critical reflective process entailed a change in meaning perspective, described
      as a shift from the position of an Idealistic Helper to an Enterprising Learner. 
      Of importance in this process were "disorienting dilemmas" that challenged
      personal perceptions. Critical reflection over such dilemmas led to deeper
      understanding facilitating the process of change. The essential lesson learned is
      that the baseline for understanding others is an understanding of one's own
      meaning perspectives and manner of participation in relation to others and their 
      context. The insights gained have implications for physiotherapists working in
      development contexts, for other development workers, and for physiotherapists
      working with patients in clinical practice in a nondevelopment context. Exploring
      how to collaborate in development contexts could be done using reflective groups 
      with expatriate and local physiotherapists and/or patients. This could lead to
      greater understanding of oneself, each other, and the local context.
FAU - Wickford, Jenny
AU  - Wickford J
AD  - Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University
      of Gothenburg, S-40530 Gothenburg, Sweden. jenny.wickford@neuro.gu.se
FAU - Rosberg, Susanne
AU  - Rosberg S
LA  - eng
PT  - Journal Article
DEP - 20111102
PL  - England
TA  - Physiother Theory Pract
JT  - Physiotherapy theory and practice
JID - 9015520
SB  - IM
MH  - Afghanistan
MH  - Anthropology, Cultural
MH  - Attitude of Health Personnel
MH  - Clinical Competence
MH  - Communication Barriers
MH  - Comprehension
MH  - Cooperative Behavior
MH  - Cultural Characteristics
MH  - Delivery of Health Care
MH  - Developing Countries
MH  - Disabled Persons/rehabilitation
MH  - Education, Professional/*methods
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - International Cooperation
MH  - Language
MH  - *Learning
MH  - Organizations
MH  - Physical Therapists/*education/psychology
MH  - Physical Therapy Specialty/*education
MH  - *Professional Practice
MH  - Professional Role
MH  - Professional-Patient Relations
MH  - Social Behavior
MH  - *Staff Development
MH  - Sweden
EDAT- 2011/11/04 06:00
MHDA- 2012/09/25 06:00
CRDT- 2011/11/04 06:00
PHST- 2011/11/04 06:00 [entrez]
PHST- 2011/11/04 06:00 [pubmed]
PHST- 2012/09/25 06:00 [medline]
AID - 10.3109/09593985.2011.608114 [doi]
PST - ppublish
SO  - Physiother Theory Pract. 2012 May;28(4):283-91. doi:
      10.3109/09593985.2011.608114. Epub 2011 Nov 2.


PMID- 22047193
OWN - NLM
STAT- MEDLINE
DCOM- 20120208
LR  - 20211021
IS  - 1475-2875 (Electronic)
IS  - 1475-2875 (Linking)
VI  - 10
DP  - 2011 Nov 3
TI  - Malaria with neurological involvement in Ugandan children: effect on cognitive
      ability, academic achievement and behaviour.
PG  - 334
LID - 10.1186/1475-2875-10-334 [doi]
AB  - BACKGROUND: Malaria is a leading cause of ill health and neuro-disability in
      children in sub-Saharan Africa. Impaired cognition is a common outcome of malaria
      with neurological involvement. There is also a possibility that academic
      achievement may be affected by malaria with neurological involvement given the
      association between cognitive ability and academic achievement. This study
      investigated the effect of malaria with neurological involvement on cognitive
      ability, behaviour and academic achievement. METHODS: This prospective
      case-control study was carried out in Kampala City, Uganda between February 2008 
      and October 2010. Sixty-two children with a history of malaria with neurological 
      involvement were followed up and given assessments for cognitive ability (working
      memory, reasoning, learning, visual spatial skills and attention), behaviour
      (internalizing and externalizing problems) and academic achievement (arithmetic, 
      spelling and reading) three months after the illness. Sixty-one community
      controls recruited from the homes or neighbouring families of the cases were also
      given the same assessments. Tests scores of the two groups were compared using
      analysis of covariance with age, sex, level of education, nutritional status and 
      quality of the home environment as covariates. This study was approved by the
      relevant ethical bodies and informed consent sought from the caregivers. RESULTS:
      Children in the malaria group had more behavioural problems than the community
      controls for internalizing problems (estimated mean difference = -3.71, 95%
      confidence interval (CI), = -6.34 to -1.08, p = 0.007). There was marginal
      evidence of lower attention scores (0.40, CI = -0.05 to 0.86, p = 0.09). However,
      excluding one child from the analyses who was unable to perform the tests
      affected the attention scores to borderline significance (0.32, CI, = 0.01 to
      0.62, p = 0.05). No significant differences were observed in other cognitive
      abilities or in academic achievement scores. CONCLUSION: Malaria with
      neurological involvement affects behaviour, with a minimal effect on attention
      but no detectable effect on academic achievement at three months post discharge. 
      This study provides evidence that development of cognitive deficits after malaria
      with neurological involvement could be gradual with less effect observed in the
      short term compared to the long term.
CI  - (c) 2011 Bangirana et al; licensee BioMed Central Ltd.
FAU - Bangirana, Paul
AU  - Bangirana P
AD  - Department of Psychiatry, Makerere University College of Health Sciences,
      Kampala, Uganda. pbangirana@yahoo.com
FAU - Musisi, Seggane
AU  - Musisi S
FAU - Boivin, Michael J
AU  - Boivin MJ
FAU - Ehnvall, Anna
AU  - Ehnvall A
FAU - John, Chandy C
AU  - John CC
FAU - Bergemann, Tracy L
AU  - Bergemann TL
FAU - Allebeck, Peter
AU  - Allebeck P
LA  - eng
GR  - D43 NS078280/NS/NINDS NIH HHS/United States
GR  - 5R01NS055349/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20111103
PL  - England
TA  - Malar J
JT  - Malaria journal
JID - 101139802
SB  - IM
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Cognition Disorders/*epidemiology
MH  - Female
MH  - Humans
MH  - Learning Disabilities/*epidemiology
MH  - Malaria, Cerebral/*complications/*epidemiology
MH  - Male
MH  - Mental Disorders/*epidemiology
MH  - Prospective Studies
MH  - Uganda/epidemiology
PMC - PMC3225331
EDAT- 2011/11/04 06:00
MHDA- 2012/02/09 06:00
CRDT- 2011/11/04 06:00
PHST- 2011/08/11 00:00 [received]
PHST- 2011/11/03 00:00 [accepted]
PHST- 2011/11/04 06:00 [entrez]
PHST- 2011/11/04 06:00 [pubmed]
PHST- 2012/02/09 06:00 [medline]
AID - 1475-2875-10-334 [pii]
AID - 10.1186/1475-2875-10-334 [doi]
PST - epublish
SO  - Malar J. 2011 Nov 3;10:334. doi: 10.1186/1475-2875-10-334.


PMID- 22047126
OWN - NLM
STAT- MEDLINE
DCOM- 20120116
LR  - 20211021
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 11
IP  - 11
DP  - 2011 Nov
TI  - Legitimate and ethical: distinguishing when and how regulations apply in
      patient-oriented research.
PG  - 42-3
LID - 10.1080/15265161.2011.603810 [doi]
FAU - Lee, Simon J Craddock
AU  - Lee SJ
AD  - UT Southwestern Medical Center, Clinical Sciences, 5323 Harry Hines Blvd,
      Dallas,TX 75390-9070, USA. simoncraddock.lee@utsouthwestern.edu
FAU - Tiro, Jasmin A
AU  - Tiro JA
FAU - Bishop, Wendy Pechero
AU  - Bishop WP
FAU - Sheppard, P Diane
AU  - Sheppard PD
FAU - Skinner, Celette Sugg
AU  - Skinner CS
LA  - eng
GR  - P30 CA142543/CA/NCI NIH HHS/United States
GR  - UL1 RR024982/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2011 Nov;11(11):31-8. PMID: 22047124
MH  - *Beneficence
MH  - Confidentiality/*ethics/*legislation & jurisprudence
MH  - *Health Insurance Portability and Accountability Act
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Patient Selection/*ethics
MH  - *Personal Autonomy
MH  - Research/*organization & administration
MH  - *Research Personnel
PMC - PMC5314433
MID - NIHMS848412
EDAT- 2011/11/04 06:00
MHDA- 2012/01/17 06:00
CRDT- 2011/11/04 06:00
PHST- 2011/11/04 06:00 [entrez]
PHST- 2011/11/04 06:00 [pubmed]
PHST- 2012/01/17 06:00 [medline]
AID - 10.1080/15265161.2011.603810 [doi]
PST - ppublish
SO  - Am J Bioeth. 2011 Nov;11(11):42-3. doi: 10.1080/15265161.2011.603810.


PMID- 22047113
OWN - NLM
STAT- MEDLINE
DCOM- 20120116
LR  - 20111103
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 11
IP  - 11
DP  - 2011 Nov
TI  - Should the "slow code" be resuscitated?
PG  - 8-12
LID - 10.1080/15265161.2011.603793 [doi]
AB  - Most bioethicists and professional medical societies condemn the practice of
      "slow codes." The American College of Physicians ethics manual states, "Because
      it is deceptive, physicians or nurses should not perform half-hearted
      resuscitation efforts ('slow codes')." A leading textbook calls slow codes
      "dishonest, crass dissimulation, and unethical." A medical sociologist describes 
      them as "deplorable, dishonest and inconsistent with established ethical
      principles." Nevertheless, we believe that slow codes may be appropriate and
      ethically defensible in situations in which cardiopulmonary resuscitation (CPR)
      is likely to be ineffective, the family decision makers understand and accept
      that death is inevitable, and those family members cannot bring themselves to
      consent or even assent to a do-not-resuscitate (DNR) order. In such cases, we
      argue, physicians may best serve both the patient and the family by having a
      carefully ambiguous discussion about end-of-life options and then providing
      resuscitation efforts that are less vigorous or prolonged than usual.
FAU - Lantos, John D
AU  - Lantos JD
AD  - Children's Mercy Bioethics Center, 2401 Gillham Road, Kansas City, MO 64108, USA.
      jlantos@cmh.edu
FAU - Meadow, William L
AU  - Meadow WL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CIN - Am J Bioeth. 2011 Nov;11(11):13-4. PMID: 22047114
CIN - Am J Bioeth. 2011 Nov;11(11):15-6. PMID: 22047115
CIN - Am J Bioeth. 2011 Nov;11(11):17-8. PMID: 22047116
CIN - Am J Bioeth. 2011 Nov;11(11):18-20. PMID: 22047117
CIN - Am J Bioeth. 2011 Nov;11(11):20-1. PMID: 22047118
CIN - Am J Bioeth. 2011 Nov;11(11):22-3. PMID: 22047119
CIN - Am J Bioeth. 2011 Nov;11(11):24-5. PMID: 22047120
CIN - Am J Bioeth. 2011 Nov;11(11):26-7. PMID: 22047121
CIN - Am J Bioeth. 2011 Nov;11(11):27-9. PMID: 22047122
CIN - Am J Bioeth. 2011 Nov;11(11):29-30. PMID: 22047123
MH  - Advance Directives/ethics
MH  - Cardiopulmonary Resuscitation/*ethics
MH  - *Deception
MH  - Decision Making/*ethics
MH  - Empathy
MH  - *Family/psychology
MH  - Humans
MH  - *Informed Consent/ethics
MH  - *Medical Futility/ethics
MH  - Physician's Role
MH  - Resuscitation Orders/*ethics
MH  - United States
MH  - Withholding Treatment
EDAT- 2011/11/04 06:00
MHDA- 2012/01/17 06:00
CRDT- 2011/11/04 06:00
PHST- 2011/11/04 06:00 [entrez]
PHST- 2011/11/04 06:00 [pubmed]
PHST- 2012/01/17 06:00 [medline]
AID - 10.1080/15265161.2011.603793 [doi]
PST - ppublish
SO  - Am J Bioeth. 2011 Nov;11(11):8-12. doi: 10.1080/15265161.2011.603793.


PMID- 22046815
OWN - NLM
STAT- MEDLINE
DCOM- 20120112
LR  - 20111103
IS  - 0048-7848 (Print)
IS  - 0048-7848 (Linking)
VI  - 115
IP  - 3
DP  - 2011 Jul-Sep
TI  - [Interactions between oral anticoagulants and other medication in emergency
      department--a pharmacoepidemiologic approach].
PG  - 954-60
AB  - UNLABELLED: Oral anticoagulants (OAC) are commonly used as a life-long therapy in
      the prevention of systemic embolism in patients with atrial fibrillation,
      valvular heart disease, prosthetic heart valves, and in the primary and secondary
      prevention of venous thromboembolism, in patients with acute myocardial
      infarction and angina pectoris. Drugs, herbs, and multivitamin supplements can
      alter the absorption, pharmacokinetics or pharmacodynamics of OAC. AIM: To
      investigate the possible interactions between oral anticoagulants and different
      drugs administered in patients in emergency department. METHODS: This 1-year
      exploratory investigation on 93 patients on OAC (aged 30 - 85 years), admitted at
      two emergency departments of the Iasi "Sf. Spiridon" Hospital and Piatra Neamt
      Hospital, consisted in their medical records analysis: diagnosis, recommended
      treatement. Data were scored and statistically analyzed by t-test (Windows
      Excel). The experimental protocol was in agreement with the recommendations of
      the Gr.T. Popa University Committee for Research and Ethical Issues. RESULTS AND 
      CONCLUSIONS: Analysis and statistical processing of data shows that during the
      study period 56 patients which received oral anticoagulant therapy associated
      with different other medication belonged to the 60 and 80 years age group. This
      finding suggests that the pathology is represented especially by atrial
      fibrillation and myocardial infarction. The correlation between the therapy
      consisting in OAC and sartan or nonsteroidal anti-inflammatory drugs and
      International Normalized Ratio (INR), revealed a high level of anticoagulation
      and an increase in hemorragic complications.
FAU - Apostoae, F
AU  - Apostoae F
AD  - Universitatii de Medicina si Farmacie "Gr. T. Popa" Iasi, Romania.
FAU - Tartau, Liliana
AU  - Tartau L
FAU - Lupusoru, Catalina-Elena
AU  - Lupusoru CE
LA  - rum
PT  - English Abstract
PT  - Journal Article
PT  - Multicenter Study
TT  - Interactiuni intre anticoagulantele orale si alte medicamente in unitatile de
      primire urgente--o abordare farmacoepidemiologica.
PL  - Romania
TA  - Rev Med Chir Soc Med Nat Iasi
JT  - Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi
JID - 0413735
RN  - 0 (Angiotensin II Type 1 Receptor Blockers)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Anticoagulants)
SB  - IM
MH  - Administration, Oral
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Angiotensin II Type 1 Receptor Blockers/administration & dosage/adverse effects
MH  - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/adverse effects
MH  - Anticoagulants/*administration & dosage/adverse effects
MH  - Atrial Fibrillation/drug therapy
MH  - Dose-Response Relationship, Drug
MH  - Drug Interactions
MH  - Emergency Service, Hospital
MH  - Female
MH  - Heart Valve Diseases/drug therapy
MH  - Heart Valve Prosthesis/adverse effects
MH  - Hemorrhage/chemically induced/prevention & control
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Romania
MH  - Stroke/drug therapy/prevention & control
MH  - Venous Thromboembolism/etiology/*prevention & control
EDAT- 2011/11/04 06:00
MHDA- 2012/01/13 06:00
CRDT- 2011/11/04 06:00
PHST- 2011/11/04 06:00 [entrez]
PHST- 2011/11/04 06:00 [pubmed]
PHST- 2012/01/13 06:00 [medline]
PST - ppublish
SO  - Rev Med Chir Soc Med Nat Iasi. 2011 Jul-Sep;115(3):954-60.


PMID- 22046495
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20220410
IS  - 2042-5333 (Electronic)
IS  - 2042-5333 (Linking)
VI  - 2
IP  - 10
DP  - 2011 Oct
TI  - Patient and provider delays in breast cancer patients attending a tertiary care
      centre: a prospective study.
PG  - 76
LID - 10.1258/shorts.2011.011006 [doi]
AB  - OBJECTIVES: To find out factors that are responsible for the patient or provider 
      delays in the diagnosis of breast cancer in India. DESIGN: This prospective study
      was designed to be conducted over a period of two years including a cohort of 100
      patients with locally advanced breast cancer. The delays were assessed using
      questionnaires prepared according to the Indian scenario. SETTING: A prospective 
      study in an Indian setting. PARTICIPANTS: One hundred patients with locally
      advanced breast cancer receiving neoadjuvant chemotherapy were included after
      providing informed consent and receiving ethical committee clearance. MAIN
      OUTCOME MEASURES: The most common factor responsible for delays in diagnosis was 
      observed to be the health providers, although illiteracy and lack of adequate
      healthcare services also contributed significantly. Unregistered medical
      practitioners or quacks contributed significantly to the delays in reporting and 
      diagnosis of the disease. RESULTS: One hundred patients of locally advanced
      breast cancer were evaluated using standardized questionnaires to assess the
      delays in diagnosis. Provider delays were found to be significant (the
      unregistered doctors or quacks being a significant cause of delays).The average
      time lapse before diagnosis for rural patients was higher (67.5 days) compared to
      urban patients (53.7 days). The literacy levels of the patients also had a
      significant impact on the delays at diagnosis. The delay in illiterates was 60.6 
      days compared to 49.5 days for literates. CONCLUSIONS: The most common factor
      responsible for delays in reporting and diagnosis was observed to be at the end
      of the health providers, although illiteracy and lack of adequate healthcare
      services also contributed significantly. Unregistered medical practitioners or
      quacks contributed significantly to the delays in reporting and diagnosis of the 
      disease.
FAU - Chintamani
AU  - Chintamani
AD  - Department of Surgery and Vardhman Mahavir Medical College, Safdarjang Hospital ,
      New Delhi , India.
FAU - Tuteja, Amita
AU  - Tuteja A
FAU - Khandelwal, Rohan
AU  - Khandelwal R
FAU - Tandon, Megha
AU  - Tandon M
FAU - Bamal, Rahul
AU  - Bamal R
FAU - Jain, Sidharth
AU  - Jain S
FAU - Narayan, Nikhil
AU  - Narayan N
FAU - Srinivas, S
AU  - Srinivas S
FAU - Kumar, Yashwant
AU  - Kumar Y
LA  - eng
PT  - Journal Article
DEP - 20111010
PL  - England
TA  - JRSM Short Rep
JT  - JRSM short reports
JID - 101536254
PMC - PMC3205556
EDAT- 2011/11/03 06:00
MHDA- 2011/11/03 06:01
CRDT- 2011/11/03 06:00
PHST- 2011/11/03 06:00 [entrez]
PHST- 2011/11/03 06:00 [pubmed]
PHST- 2011/11/03 06:01 [medline]
AID - 10.1258/shorts.2011.011006 [doi]
AID - SHORTS-11-006 [pii]
PST - ppublish
SO  - JRSM Short Rep. 2011 Oct;2(10):76. doi: 10.1258/shorts.2011.011006. Epub 2011 Oct
      10.


PMID- 22046230
OWN - NLM
STAT- MEDLINE
DCOM- 20120326
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 6
IP  - 10
DP  - 2011
TI  - Repeated assessments of informed consent comprehension among HIV-infected
      participants of a three-year clinical trial in Botswana.
PG  - e22696
LID - 10.1371/journal.pone.0022696 [doi]
AB  - BACKGROUND: Informed consent (IC) has been an international standard for decades 
      for the ethical conduct of clinical trials. Yet frequently study participants
      have incomplete understanding of key issues, a problem exacerbated by language
      barriers or lack of familiarity with research concepts. Few investigators measure
      participant comprehension of IC, while even fewer conduct interim assessments
      once a trial is underway. METHODS AND FINDINGS: We assessed comprehension of IC
      using a 20-question true/false quiz administered in 6-month intervals in the
      context of a placebo-controlled, randomized trial for the prevention of
      tuberculosis among HIV-infected adults in Botswana (2004-2009). Quizzes were
      offered in both Setswana and English. To enroll in the TB trial, participants
      were required to have >/= 16/20 correct responses. We examined concepts
      understood and the degree to which understanding changed over three-years. We
      analyzed 5,555 quizzes from 1,835 participants. The participants' highest
      education levels were: 28% primary, 59% secondary, 9% tertiary and 7% no formal
      education. Eighty percent of participants passed the enrollment quiz (Quiz1) on
      their first attempt and the remainder passed on their second attempt. Those
      having higher than primary education and those who took the quiz in English were 
      more likely to receive a passing score on their first attempt (adjusted odds
      ratios and 95% confidence intervals, 3.1 (2.4-4.0) and 1.5 (1.2, 1.9),
      respectively). The trial's purpose or procedures were understood by 90-100% of
      participants, while 44-77% understood randomization, placebos, or risks.
      Participants who failed Quiz1 on their initial attempt were more likely to fail
      quizzes later in the trial. Pass rates improved with quiz re-administration in
      subsequent years. CONCLUSIONS: Administration of a comprehension quiz at
      enrollment and during follow-up was feasible in a large, international
      collaboration and efficiently determined IC comprehension by trial participants. 
      Strategies to improve understanding of concepts like placebos and randomization
      are needed. Comprehension assessments throughout a study may reinforce key
      concepts.
FAU - Chaisson, Lelia H
AU  - Chaisson LH
AD  - Berman Institute of Bioethics, Johns Hopkins University, Baltimore, Maryland,
      United States of America.
FAU - Kass, Nancy E
AU  - Kass NE
FAU - Chengeta, Bafanana
AU  - Chengeta B
FAU - Mathebula, Unami
AU  - Mathebula U
FAU - Samandari, Taraz
AU  - Samandari T
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20111027
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adult
MH  - Aged
MH  - Botswana
MH  - Comprehension/*ethics
MH  - Educational Status
MH  - Female
MH  - *HIV Infections
MH  - Humans
MH  - Informed Consent/*psychology/standards
MH  - International Cooperation
MH  - Male
MH  - Middle Aged
MH  - Patient Education as Topic/*ethics
MH  - Patient Selection/*ethics
MH  - Surveys and Questionnaires
MH  - Young Adult
PMC - PMC3203064
EDAT- 2011/11/03 06:00
MHDA- 2012/03/27 06:00
CRDT- 2011/11/03 06:00
PHST- 2011/01/20 00:00 [received]
PHST- 2011/07/05 00:00 [accepted]
PHST- 2011/11/03 06:00 [entrez]
PHST- 2011/11/03 06:00 [pubmed]
PHST- 2012/03/27 06:00 [medline]
AID - 10.1371/journal.pone.0022696 [doi]
AID - PONE-D-11-01662 [pii]
PST - ppublish
SO  - PLoS One. 2011;6(10):e22696. doi: 10.1371/journal.pone.0022696. Epub 2011 Oct 27.


PMID- 22045897
OWN - NLM
STAT- MEDLINE
DCOM- 20120228
LR  - 20220317
IS  - 1526-3347 (Electronic)
IS  - 0191-9601 (Linking)
VI  - 32
IP  - 11
DP  - 2011 Nov
TI  - Ethics for the pediatrician: genetic testing and newborn screening.
PG  - 490-3
LID - 10.1542/pir.32-11-490 [doi]
FAU - Gonzales, Janis L
AU  - Gonzales JL
AD  - Children's Medical Services, New Mexico Department of Health, Santa Fe, NM, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Pediatr Rev
JT  - Pediatrics in review
JID - 8103046
SB  - IM
MH  - Genetic Carrier Screening
MH  - Genetic Testing/*ethics
MH  - Healthcare Disparities/ethics
MH  - Humans
MH  - Infant, Newborn
MH  - Minority Groups
MH  - Neonatal Screening/*ethics
MH  - Pediatrics/*ethics
EDAT- 2011/11/03 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/11/03 06:00
PHST- 2011/11/03 06:00 [entrez]
PHST- 2011/11/03 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - 32/11/490 [pii]
AID - 10.1542/pir.32-11-490 [doi]
PST - ppublish
SO  - Pediatr Rev. 2011 Nov;32(11):490-3. doi: 10.1542/pir.32-11-490.


PMID- 22045726
OWN - NLM
STAT- MEDLINE
DCOM- 20130103
LR  - 20191210
IS  - 1477-030X (Electronic)
IS  - 0269-2163 (Linking)
VI  - 26
IP  - 7
DP  - 2012 Oct
TI  - Assessing quality of care for the dying: the development and initial validation
      of a postal self-completion questionnaire for bereaved relatives.
PG  - 897-907
AB  - BACKGROUND: Evaluating 'quality of care for the dying' from the patients'
      perspective has practical and ethical difficulties: an alternative is to use
      bereaved relatives' views as 'proxy' measures. Currently, within the United
      Kingdom, there is no validated instrument which specifically examines quality of 
      care in the last days of life or the impact of the Liverpool Care Pathway (LCP)
      for the Dying Patient. AIM: To develop and validate a questionnaire for use with 
      bereaved relatives assessing the quality of care for patients and families in the
      last days of life and the immediate period after the bereavement. DESIGN: The
      instrument, 'Evaluating Care and Health Outcomes - for the Dying' (ECHO-D), was
      developed in four distinct phases: 1. Question formulation, 2. Expert panel
      review (n = 6), 3. Wider audience review (n = 25), 4. Pilot, including cognitive 
      pre-testing interviews and preliminary test-retest reliability assessment with
      bereaved relatives (n = 80) SETTING: The study was conducted within a hospice and
      an acute hospital involving healthcare professionals, lay members and bereaved
      relatives. RESULTS: The systematic and robust process of questionnaire
      development generated evidence for ECHO-D's face and content validity. Response
      rate for the pilot stage with bereaved relatives, however, was comparatively low 
      (23.4%). Test-retest analysis from the pilot showed moderate or good stability
      for 13 out of 17 key questions, although small sample numbers limited the
      interpretation. CONCLUSIONS: ECHO-D is the first instrument specifically to
      assess 'quality of care for the dying', focussing on the last days of life, and
      has direct links with the use of the LCP Programme.
FAU - Mayland, Catriona R
AU  - Mayland CR
AD  - Marie Curie Palliative Care Institute, University of Liverpool, Liverpool, UK.
      catriona.mayland@aintree.nhs.uk
FAU - Williams, Evelyn M I
AU  - Williams EM
FAU - Ellershaw, John E
AU  - Ellershaw JE
LA  - eng
PT  - Journal Article
PT  - Validation Study
DEP - 20111101
PL  - England
TA  - Palliat Med
JT  - Palliative medicine
JID - 8704926
SB  - IM
MH  - Aged
MH  - *Bereavement
MH  - Family/*psychology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - Quality of Health Care/*standards
MH  - Reproducibility of Results
MH  - Surveys and Questionnaires/*standards
MH  - Terminal Care/psychology/*standards
MH  - Terminally Ill
MH  - United Kingdom
EDAT- 2011/11/03 06:00
MHDA- 2013/01/04 06:00
CRDT- 2011/11/03 06:00
PHST- 2011/11/03 06:00 [entrez]
PHST- 2011/11/03 06:00 [pubmed]
PHST- 2013/01/04 06:00 [medline]
AID - 0269216311424953 [pii]
AID - 10.1177/0269216311424953 [doi]
PST - ppublish
SO  - Palliat Med. 2012 Oct;26(7):897-907. doi: 10.1177/0269216311424953. Epub 2011 Nov
      1.


PMID- 22045433
OWN - NLM
STAT- MEDLINE
DCOM- 20120425
LR  - 20131121
IS  - 1496-8975 (Electronic)
IS  - 0832-610X (Linking)
VI  - 59
IP  - 1
DP  - 2012 Jan
TI  - Use of a novel technique, solid phase microextraction, to measure tranexamic acid
      in patients undergoing cardiac surgery.
PG  - 14-20
LID - 10.1007/s12630-011-9614-3 [doi]
AB  - PURPOSE: Solid phase microextraction (SPME) is a technique widely used and
      accepted in the field of food technology and in environmental and biological
      analyses. Despite its numerous advantages over older analytical methods, it has
      not been studied extensively in the medical sciences. Tranexamic acid (TXA) is
      currently the sole antifibrinolytic agent used during cardiac surgery involving
      the use of cardiopulmonary bypass (CPB). The current standard method of measuring
      TXA in plasma is based on plasma protein precipitation (PPP), but this analytical
      approach is time-consuming and not practical for routine use. The aim of the
      current study was to compare plasma TXA levels measured with the PPP method vs
      those acquired with the novel, highly efficient SPME technique. We also
      investigated the use of automated SPME with the aim of improving the technique so
      it could be used efficiently for measuring plasma TXA levels. METHODS: With
      Research Ethics Board approval, we undertook a prospective, investigator-blinded 
      study in ten patients undergoing cardiac surgery with CPB. An initial TXA bolus
      of 30 mg.kg(-1) was infused over 15 min followed by a 16 mg.kg(-1).hr(-1)
      infusion until chest closure with a 2 mg.kg(-1) load in the pump prime. Each
      blood sample was divided into two portions and assigned a random number to blind 
      the analyzing laboratory. The blood TXA concentration was measured using both PPP
      and SPME. Agreement between the two tests was analyzed using the Bland-Altman
      plot. RESULTS: Comparisons of plasma TXA concentrations measured with the two
      methods (PPP and SPME) showed good agreement. Absolute recovery of TXA for PPP
      was 64.9-78.2%; its precision, as a percentage of the relative standard deviation
      (RSD) was < 10% [with the exception of the lower limit of quantification (LLOQ), 
      where the RSD was 18%]; and its accuracy, as the bias against the nominal
      concentration, was < 7% (for LLOQ it was 15%). Thus, extraction with SPME
      compared favourably with the PPP technique. CONCLUSIONS: Solid phase
      microextraction is a relatively simple, rapid extraction technique that can
      facilitate future pharmacokinetic studies analyzing TXA drug concentrations and
      drug dosing in various clinical settings.
FAU - Wasowicz, Marcin
AU  - Wasowicz M
AD  - Department of Anesthesia and Pain Management, Toronto General Hospital, 200
      Elizabeth Street, Toronto, ON M5G 2C4, Canada. marcin.wasowicz@uhn.on.ca
FAU - Jerath, Angela
AU  - Jerath A
FAU - Bojko, Barbara
AU  - Bojko B
FAU - Sharma, Vivek
AU  - Sharma V
FAU - Pawliszyn, Janusz
AU  - Pawliszyn J
FAU - McCluskey, Stuart
AU  - McCluskey S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20111102
PL  - United States
TA  - Can J Anaesth
JT  - Canadian journal of anaesthesia = Journal canadien d'anesthesie
JID - 8701709
RN  - 0 (Antifibrinolytic Agents)
RN  - 0 (Proteins)
RN  - 6T84R30KC1 (Tranexamic Acid)
SB  - IM
MH  - Aged
MH  - Antifibrinolytic Agents/*blood/therapeutic use
MH  - Cardiac Surgical Procedures/methods
MH  - Cardiopulmonary Bypass/*methods
MH  - Chemical Precipitation
MH  - Female
MH  - Humans
MH  - Infusions, Intravenous
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Proteins/chemistry
MH  - Single-Blind Method
MH  - Solid Phase Microextraction/*methods
MH  - Tranexamic Acid/*blood/therapeutic use
EDAT- 2011/11/03 06:00
MHDA- 2012/04/26 06:00
CRDT- 2011/11/03 06:00
PHST- 2011/06/29 00:00 [received]
PHST- 2011/10/18 00:00 [accepted]
PHST- 2011/11/03 06:00 [entrez]
PHST- 2011/11/03 06:00 [pubmed]
PHST- 2012/04/26 06:00 [medline]
AID - 10.1007/s12630-011-9614-3 [doi]
PST - ppublish
SO  - Can J Anaesth. 2012 Jan;59(1):14-20. doi: 10.1007/s12630-011-9614-3. Epub 2011
      Nov 2.


PMID- 22045374
OWN - NLM
STAT- MEDLINE
DCOM- 20120229
LR  - 20151119
IS  - 1873-6513 (Electronic)
IS  - 0885-3924 (Linking)
VI  - 42
IP  - 5
DP  - 2011 Nov
TI  - Responding to surrogate requests that seem inconsistent with a patient's living
      will.
PG  - 777-82
LID - 10.1016/j.jpainsymman.2011.08.003 [doi]
AB  - Clinicians may feel conflicted when a patient's legal decision maker is making
      decisions that seem inconsistent with a patient's living will. We provide
      evidence-based information to help clinicians consider whether a surrogate's
      inconsistent decisions are ethically appropriate. Surrogates are not flawless
      translators of their loved one's preferences; they are influenced by their own
      hopes and the current clinical context. Patients may be aware of this, are often 
      concerned about burdening their loved ones, and often grant their surrogates
      leeway in interpreting their wishes. When appropriate, clinicians should respect 
      surrogates' interpretations of patient values and take steps to decrease
      surrogate stress during the decision-making process. Finally, if clinicians are
      cognizant of their own values and preferences, they may recognize how these may
      affect their responses to certain clinical cases.
CI  - Copyright A(c) 2011 U.S. Cancer Pain Relief Committee. All rights reserved.
FAU - Vig, Elizabeth K
AU  - Vig EK
AD  - VA Puget Sound Health Care System and University of Washington, Seattle,
      Washington, USA. vigster@u.washington.edu
FAU - Sudore, Rebecca L
AU  - Sudore RL
FAU - Berg, Karina M
AU  - Berg KM
FAU - Fromme, Erik K
AU  - Fromme EK
FAU - Arnold, Robert M
AU  - Arnold RM
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Pain Symptom Manage
JT  - Journal of pain and symptom management
JID - 8605836
SB  - IM
MH  - Advance Directive Adherence
MH  - Advance Directives
MH  - Aged, 80 and over
MH  - Critical Care
MH  - Female
MH  - Guidelines as Topic
MH  - Humans
MH  - *Living Wills/ethics
MH  - *Third-Party Consent/ethics
EDAT- 2011/11/03 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/11/03 06:00
PHST- 2011/05/10 00:00 [received]
PHST- 2011/08/25 00:00 [revised]
PHST- 2011/09/01 00:00 [accepted]
PHST- 2011/11/03 06:00 [entrez]
PHST- 2011/11/03 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - S0885-3924(11)00427-1 [pii]
AID - 10.1016/j.jpainsymman.2011.08.003 [doi]
PST - ppublish
SO  - J Pain Symptom Manage. 2011 Nov;42(5):777-82. doi:
      10.1016/j.jpainsymman.2011.08.003.


PMID- 22044906
OWN - NLM
STAT- MEDLINE
DCOM- 20120301
LR  - 20111102
IS  - 1473-5695 (Electronic)
IS  - 0969-9546 (Linking)
VI  - 18
IP  - 6
DP  - 2011 Dec
TI  - Ethics in emergency medicine conferences.
PG  - 313
LID - 10.1097/MEJ.0b013e32834e60ab [doi]
FAU - Graham, Colin A
AU  - Graham CA
LA  - eng
PT  - Editorial
PL  - England
TA  - Eur J Emerg Med
JT  - European journal of emergency medicine : official journal of the European Society
      for Emergency Medicine
JID - 9442482
SB  - IM
MH  - *Congresses as Topic
MH  - *Emergency Medicine
MH  - *Ethics, Medical
MH  - Europe
MH  - Humans
MH  - Societies, Medical
EDAT- 2011/11/03 06:00
MHDA- 2012/03/02 06:00
CRDT- 2011/11/03 06:00
PHST- 2011/11/03 06:00 [entrez]
PHST- 2011/11/03 06:00 [pubmed]
PHST- 2012/03/02 06:00 [medline]
AID - 10.1097/MEJ.0b013e32834e60ab [doi]
AID - 00063110-201112000-00001 [pii]
PST - ppublish
SO  - Eur J Emerg Med. 2011 Dec;18(6):313. doi: 10.1097/MEJ.0b013e32834e60ab.


PMID- 22044767
OWN - NLM
STAT- MEDLINE
DCOM- 20120514
LR  - 20120131
IS  - 1532-2793 (Electronic)
IS  - 0260-6917 (Linking)
VI  - 32
IP  - 2
DP  - 2012 Feb
TI  - The development of service users in the provision of verbal feedback to student
      nurses in a clinical simulation environment.
PG  - 133-8
LID - 10.1016/j.nedt.2011.10.003 [doi]
AB  - The School of Nursing and Midwifery at Robert Gordon University, Aberdeen, has a 
      sustained history of working in partnership with service users in their role as
      patient volunteers. The patient volunteers make a pivotal contribution towards
      the delivery of clinical skills as "real" patients. They work within a scenario
      context, overseen and facilitated by academic staff. Evaluations have identified 
      that the patient volunteers find this experience rewarding, worthwhile and a way 
      of contributing to the education of student nurses. Whilst this is already a
      successful element of the student's learning, staff were cognisant of the need to
      develop this aspect further. A case study approach was adopted to review the
      experience of the patient volunteers in their provision of feedback to students. 
      In accordance with the evidence base, it was proposed to enhance the volunteer
      patient's role in providing verbal face to face feedback to students. An
      educational package for the patient volunteers was developed and a current
      simulation event within the curriculum was identified that would allow the
      volunteers to practice giving feedback. This was then evaluated and following
      ethical approval, a series of focus groups were undertaken with the patient
      volunteers. The data collected identified the strengths and limitations of this
      experience and as a result of this an implementation plan was identified aimed at
      enhancing the patient volunteer's and the student's experience.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Webster, Brian J
AU  - Webster BJ
AD  - Robert Gordon University, Garthdee Road, Aberdeen, AB10 7QG, UK.
      b.webster1@rgu.ac.uk
FAU - Goodhand, Kate
AU  - Goodhand K
FAU - Haith, Mark
AU  - Haith M
FAU - Unwin, Rachel
AU  - Unwin R
LA  - eng
PT  - Journal Article
DEP - 20111101
PL  - Scotland
TA  - Nurse Educ Today
JT  - Nurse education today
JID - 8511379
MH  - *Communication
MH  - Education, Nursing/*methods
MH  - Humans
MH  - *Nurse-Patient Relations
MH  - Nursing Education Research
MH  - Nursing Evaluation Research
MH  - *Patient Participation
MH  - Patient Simulation
MH  - Students, Nursing
EDAT- 2011/11/03 06:00
MHDA- 2012/05/15 06:00
CRDT- 2011/11/03 06:00
PHST- 2011/03/25 00:00 [received]
PHST- 2011/09/15 00:00 [revised]
PHST- 2011/10/03 00:00 [accepted]
PHST- 2011/11/03 06:00 [entrez]
PHST- 2011/11/03 06:00 [pubmed]
PHST- 2012/05/15 06:00 [medline]
AID - S0260-6917(11)00252-8 [pii]
AID - 10.1016/j.nedt.2011.10.003 [doi]
PST - ppublish
SO  - Nurse Educ Today. 2012 Feb;32(2):133-8. doi: 10.1016/j.nedt.2011.10.003. Epub
      2011 Nov 1.


PMID- 22044507
OWN - NLM
STAT- MEDLINE
DCOM- 20130625
LR  - 20161125
IS  - 1365-2788 (Electronic)
IS  - 0964-2633 (Linking)
VI  - 57
IP  - 2
DP  - 2013 Feb
TI  - A neuroimaging proof of principle study of Down's syndrome and dementia: ethical 
      and methodological challenges in intrusive research.
PG  - 105-18
LID - 10.1111/j.1365-2788.2011.01495.x [doi]
AB  - BACKGROUND: Research into specific illnesses and the development of new
      treatments may only become possible as new technologies become available. When
      used for research, such technologies may best be described as 'intrusive', in
      that they require a considerable willingness and commitment on the part of the
      participants. This has increasingly been the case for brain disorders and
      illnesses where novel neuroimaging techniques, often combined with clinical and
      psychological assessments, have the potential to result in new understanding.
      People with intellectual disabilities (ID) have a history of under-representation
      as participants in research using such technologies and are therefore at risk of 
      not receiving equal access to state-of-the-art treatments. We propose that
      'intrusive' biomedical research is both possible and ethical in ID, and explore
      some of the methodological challenges by reference to a recent proof of principle
      study that used a relatively new ligand-based brain scanning technique in a group
      of volunteers with Down's syndrome. METHODS: Five overlapping stages of the study
      methodology were identified and evaluated for their acceptability to volunteers
      with mild to moderate ID through discussion, reflection, and analysis of
      structured feedback in the context of key policy documents, ethical guidelines
      and relevant legislation. RESULTS: Identification of key ethical and
      methodological challenges from reflective practice and participant feedback
      facilitated the emergence of strategies that permitted continual refinement of
      the study design. Important areas considered included (1) being clear about the
      purpose and scientific justification for the study; (2) reconciling the potential
      risks and benefits with relevant ethical guidelines and legislation; (3)
      identifying and implementing effective recruitment strategies; (4) optimising and
      assessing capacity to consent; and (5) making the 'intrusive' procedures as
      acceptable as possible to people with ID. CONCLUSION: We were able to demonstrate
      that a proof of principle study incorporating a novel brain scanning technique in
      a group of volunteers with ID was feasible, safe and well tolerated, despite the 
      vulnerabilities of the study cohort and the intrusive nature of the research. We 
      consider the study within an ethical and historical discourse about the
      principles that define current 'best practice' in ID research and propose a
      number of key recommendations for making intrusive research acceptable in people 
      with ID.
CI  - (c) 2011 The Authors. Journal of Intellectual Disability Research (c) 2011
      Blackwell Publishing Ltd.
FAU - d'Abrera, J C
AU  - d'Abrera JC
AD  - Department of Psychiatry, University of Cambridge, Cambridge, UK.
FAU - Holland, A J
AU  - Holland AJ
FAU - Landt, J
AU  - Landt J
FAU - Stocks-Gee, G
AU  - Stocks-Gee G
FAU - Zaman, S H
AU  - Zaman SH
LA  - eng
PT  - Journal Article
DEP - 20111102
PL  - England
TA  - J Intellect Disabil Res
JT  - Journal of intellectual disability research : JIDR
JID - 9206090
SB  - IM
MH  - Biomedical Research/*ethics/*methods
MH  - Brain/diagnostic imaging/pathology
MH  - Cohort Studies
MH  - Dementia/*psychology
MH  - Down Syndrome/*psychology
MH  - Feasibility Studies
MH  - Humans
MH  - Informed Consent/ethics
MH  - Magnetic Resonance Imaging/ethics/methods/psychology
MH  - Neuroimaging/*ethics/*methods/psychology
MH  - Patient Satisfaction/statistics & numerical data
MH  - Patient Selection/ethics
MH  - Positron-Emission Tomography/methods/psychology
MH  - Research Design
EDAT- 2011/11/03 06:00
MHDA- 2013/06/26 06:00
CRDT- 2011/11/03 06:00
PHST- 2011/11/03 06:00 [entrez]
PHST- 2011/11/03 06:00 [pubmed]
PHST- 2013/06/26 06:00 [medline]
AID - 10.1111/j.1365-2788.2011.01495.x [doi]
PST - ppublish
SO  - J Intellect Disabil Res. 2013 Feb;57(2):105-18. doi:
      10.1111/j.1365-2788.2011.01495.x. Epub 2011 Nov 2.


PMID- 22044488
OWN - NLM
STAT- MEDLINE
DCOM- 20120329
LR  - 20220310
IS  - 1553-2712 (Electronic)
IS  - 1069-6563 (Linking)
VI  - 18
IP  - 11
DP  - 2011 Nov
TI  - How Facebook saved our day!
PG  - 1217-9
LID - 10.1111/j.1553-2712.2011.01199.x [doi]
AB  - Facebook and social media networking applications use is ubiquitous across all
      ages and cultures. Facebook has finally begun to appear in the medical-scientific
      press. Today's medical literature is focused on concerns of professionalism in
      young health care practitioners vis-a-vis the lay public as they continuously
      expose themselves through this online social medium. With over 500 million users,
      Facebook hosts many of our patients, who are also exposed to the Internet and
      social media. Nobody so far has considered the opposite issue: that of physician 
      invasion of privacy by "looking-up" a patient on Facebook during clinical
      practice for purposes of history-taking or diagnostic clues in situations where
      patients are too ill to provide needed information. We need to consider the
      ethical implications of privacy invasion in the current era of information
      technology. We need to acquire and maintain a certain level of "social media
      competency" to better debate the issues around Facebook and how we integrate
      on-line content with our patients' histories of present illness (HPI) or past
      medical histories (if at all).
CI  - (c) 2011 by the Society for Academic Emergency Medicine.
FAU - Ben-Yakov, Maxim
AU  - Ben-Yakov M
AD  - maxim.benyakov@utoronto.ca
FAU - Snider, Carolyn
AU  - Snider C
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20111101
PL  - United States
TA  - Acad Emerg Med
JT  - Academic emergency medicine : official journal of the Society for Academic
      Emergency Medicine
JID - 9418450
SB  - IM
CIN - Acad Emerg Med. 2011 Nov;18(11):1221-2. PMID: 22092907
MH  - Adult
MH  - Amnesia/diagnosis
MH  - Confidentiality/*ethics
MH  - Emergency Medical Services/ethics
MH  - Female
MH  - Humans
MH  - *Physician-Patient Relations
MH  - *Privacy
MH  - Social Media/*ethics
EDAT- 2011/11/03 06:00
MHDA- 2012/03/30 06:00
CRDT- 2011/11/03 06:00
PHST- 2011/11/03 06:00 [entrez]
PHST- 2011/11/03 06:00 [pubmed]
PHST- 2012/03/30 06:00 [medline]
AID - 10.1111/j.1553-2712.2011.01199.x [doi]
PST - ppublish
SO  - Acad Emerg Med. 2011 Nov;18(11):1217-9. doi: 10.1111/j.1553-2712.2011.01199.x.
      Epub 2011 Nov 1.


PMID- 22044296
OWN - NLM
STAT- MEDLINE
DCOM- 20120228
LR  - 20120507
IS  - 1532-7604 (Electronic)
IS  - 1088-8705 (Linking)
VI  - 14
IP  - 3
DP  - 2011
TI  - Welfare assessments based on lifetime health and production data in Danish dairy 
      cows.
PG  - 255-64
LID - 10.1080/10888705.2011.576984 [doi]
AB  - The objective of this study was to describe how information about the whole
      lifetime of the cow can be used when defining nonhuman animal-based criteria of
      the welfare of animals on the farm. Often measured over a short period, disease
      occurrence provides information relevant for assessing the current welfare state 
      of the herd. Arguably, however, if disease records are to be used as ethically
      relevant welfare indicators, it is also important to record disease occurrence
      over the individual animal's entire life span. Thus, it matters ethically whether
      the burden of an outbreak of disease or other condition affecting animal welfare 
      is carried by a few individuals or is distributed more evenly. To illustrate this
      principle, the study obtained data on disease treatment records and production
      from 392,287 cows from the Danish Cattle Database. The average cow had lived for 
      5 years and produced more than 22,000 L of milk. The medium number of treatments 
      a cow had received for any disease was 2, but 10% of the cows had received more
      than 8 treatments for a disease. The study concluded that lifetime description
      provides a measure of disease occurrence that gives added value of ethical
      relevance to single-point prevalence or short-term incidence.
FAU - Houe, Hans
AU  - Houe H
AD  - Department of Large Animal Sciences, Faculty of Life Sciences, University of
      Copenhagen, Frederiksberg C, Denmark. houe@life.ku.dk
FAU - Sand E, Peter
AU  - Sand E P
FAU - Thomsen, Peter T
AU  - Thomsen PT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Appl Anim Welf Sci
JT  - Journal of applied animal welfare science : JAAWS
JID - 9804404
SB  - IM
MH  - *Animal Husbandry
MH  - *Animal Welfare
MH  - Animals
MH  - Cattle
MH  - Cattle Diseases/*epidemiology/etiology/prevention & control
MH  - Dairying
MH  - Denmark/epidemiology
MH  - Female
MH  - *Milk
EDAT- 2011/11/03 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/11/03 06:00
PHST- 2011/11/03 06:00 [entrez]
PHST- 2011/11/03 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - 10.1080/10888705.2011.576984 [doi]
PST - ppublish
SO  - J Appl Anim Welf Sci. 2011;14(3):255-64. doi: 10.1080/10888705.2011.576984.


PMID- 22043474
OWN - NLM
STAT- MEDLINE
DCOM- 20111206
LR  - 20210227
IS  - 1461-5185 (Print)
IS  - 1461-5185 (Linking)
VI  - 13
IP  - 5
DP  - 2011 Oct
TI  - Ethics of a clinical trial.
PG  - 403
LID - 10.3290/j.jad.a22303 [doi]
FAU - Ferrari, Marco
AU  - Ferrari M
LA  - eng
PT  - Editorial
PL  - Germany
TA  - J Adhes Dent
JT  - The journal of adhesive dentistry
JID - 100888552
RN  - 0 (Dental Materials)
MH  - Clinical Trials as Topic/*ethics
MH  - *Dental Materials
MH  - Ethics Committees, Research
MH  - *Ethics, Dental
MH  - *Ethics, Research
MH  - Helsinki Declaration
MH  - Human Experimentation/ethics
MH  - Humans
EDAT- 2011/11/02 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/11/02 06:00
PHST- 2011/11/02 06:00 [entrez]
PHST- 2011/11/02 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 842925 [pii]
AID - 10.3290/j.jad.a22303 [doi]
PST - ppublish
SO  - J Adhes Dent. 2011 Oct;13(5):403. doi: 10.3290/j.jad.a22303.


PMID- 22043376
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 2070-5204 (Electronic)
IS  - 1999-768X (Linking)
VI  - 26
IP  - 1
DP  - 2011 Jan
TI  - Attitudes towards informed consent: a comparison between surgeons working in
      saudi arabia and the United kingdom.
PG  - 29-33
LID - 10.5001/omj.2011.08 [doi]
AB  - OBJECTIVES: Changes in legal standing and new guidelines for consent have
      generated changes in medical culture that doctors must adhere to. This study aims
      to highlight the differences in the way the surgeons in the two cultures view the
      informed consent for surgery processes. METHODS: The attitudes towards informed
      consent of a group of surgeons working in Saudi Arabia (KSA) were compared with
      those of a similar group working in the United Kingdom (UK), a country with a
      longer medical history and a more established medico-legal system. RESULTS: The
      study shows that KSA surgeons tend to view informed consent not only as an
      ethical and legal obligation but also as a benefit to patients. In addition, KSA 
      surgeons are more likely to adopt a paternalistic attitude during informed
      consent. They believe that information about harmful risks may dissuade their
      patients from undergoing the operation and they admit that the amount of
      information they provide to their patients is significantly influenced by a
      number of patient and non-patient related factors. CONCLUSION: It is concluded
      that surgeons in KSA should be more aware of the informed consent guidelines and 
      they should adhere to them. In addition, there is room for the introduction of
      formal training on informed consent in both countries and for making written
      information more widely available particularly in KSA.
FAU - Jamjoom, Bakur A
AU  - Jamjoom BA
FAU - Jamjoom, Aimun A B
AU  - Jamjoom AA
FAU - Sharab, Momen
AU  - Sharab M
FAU - Jamjoom, Abdulhakim B
AU  - Jamjoom AB
LA  - eng
PT  - Journal Article
PL  - Oman
TA  - Oman Med J
JT  - Oman medical journal
JID - 101526350
PMC - PMC3191608
OTO - NOTNLM
OT  - Informed consent
OT  - Saudi Arabia
OT  - United Kingdom.
OT  - medical ethics
OT  - surgical risk
EDAT- 2011/11/02 06:00
MHDA- 2011/11/02 06:01
CRDT- 2011/11/02 06:00
PHST- 2010/05/31 00:00 [received]
PHST- 2010/07/26 00:00 [accepted]
PHST- 2011/11/02 06:00 [entrez]
PHST- 2011/11/02 06:00 [pubmed]
PHST- 2011/11/02 06:01 [medline]
AID - 10.5001/omj.2011.08 [doi]
AID - OMJ-D-10-00090 [pii]
PST - ppublish
SO  - Oman Med J. 2011 Jan;26(1):29-33. doi: 10.5001/omj.2011.08.


PMID- 22043189
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130704
LR  - 20211020
IS  - 1935-469X (Electronic)
IS  - 1554-7477 (Linking)
VI  - 7
IP  - 4
DP  - 2011 Jul
TI  - Possibly impossible patients: management of difficult behavior in oncology
      outpatients.
PG  - 242-6
LID - 10.1200/JOP.2010.000122 [doi]
AB  - Angry, threatening, or otherwise disruptive behavior by patients can interfere
      with necessary oncologic treatment, sometimes to the point of rendering continued
      care impossible. We offer oncology clinicians guidance in dealing with difficult 
      outpatients by discussing the differential diagnosis and multidisciplinary
      management of treatment-disrupting behavior in the ambulatory oncology setting.We
      review the existing literature on dealing with difficult patients and present
      clinical experience at a comprehensive cancer center where a formalized,
      institutional process for responding to disruptive outpatients has been
      developed.A structured, multidisciplinary approach to deal with difficult
      behavior in oncology outpatients can improve care and staff morale. Staff using
      this approach can identify causes of treatment-disrupting behavior, develop and
      implement appropriate behavior plans, facilitate communication, address mental
      health issues, and ensure that decisions to terminate a relationship with a
      patient are ethical, clinically justified, and supported by due process.In the
      future, clinical recommendations and institutional guidelines for dealing with
      difficult patients should be evaluated with more structured, quantitative
      research.
FAU - Peteet, John R
AU  - Peteet JR
AD  - Dana-Farber Cancer Institute, Boston; Cambridge Health Alliance, Cambridge, MA.
FAU - Meyer, Fremonta L
AU  - Meyer FL
FAU - Miovic, Michael K
AU  - Miovic MK
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Oncol Pract
JT  - Journal of oncology practice
JID - 101261852
PMC - PMC3140447
EDAT- 2011/11/02 06:00
MHDA- 2011/11/02 06:01
CRDT- 2011/11/02 06:00
PHST- 2011/01/19 00:00 [accepted]
PHST- 2011/11/02 06:00 [entrez]
PHST- 2011/11/02 06:00 [pubmed]
PHST- 2011/11/02 06:01 [medline]
AID - 10.1200/JOP.2010.000122 [doi]
AID - 3706637 [pii]
PST - ppublish
SO  - J Oncol Pract. 2011 Jul;7(4):242-6. doi: 10.1200/JOP.2010.000122.


PMID- 22043080
OWN - NLM
STAT- MEDLINE
DCOM- 20120109
LR  - 20211020
IS  - 0008-5286 (Print)
IS  - 0008-5286 (Linking)
VI  - 52
IP  - 5
DP  - 2011 May
TI  - Genetic engineering of animals: ethical issues, including welfare concerns.
PG  - 544-50
FAU - Ormandy, Elisabeth H
AU  - Ormandy EH
AD  - Canadian Council on Animal Care, 1510-130 Albert Street, Ottawa, Ontario K1P 5G4.
FAU - Dale, Julie
AU  - Dale J
FAU - Griffin, Gilly
AU  - Griffin G
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Vet J
JT  - The Canadian veterinary journal = La revue veterinaire canadienne
JID - 0004653
SB  - IM
MH  - *Animal Welfare
MH  - Animals
MH  - *Animals, Genetically Modified
MH  - Genetic Engineering/ethics/*veterinary
MH  - Veterinary Medicine/*ethics
PMC - PMC3078015
EDAT- 2011/11/02 06:00
MHDA- 2012/01/10 06:00
CRDT- 2011/11/02 06:00
PHST- 2011/11/02 06:00 [entrez]
PHST- 2011/11/02 06:00 [pubmed]
PHST- 2012/01/10 06:00 [medline]
PST - ppublish
SO  - Can Vet J. 2011 May;52(5):544-50.


PMID- 22043066
OWN - NLM
STAT- MEDLINE
DCOM- 20120109
LR  - 20211020
IS  - 0008-5286 (Print)
IS  - 0008-5286 (Linking)
VI  - 52
IP  - 5
DP  - 2011 May
TI  - Veterinary medical ethics. An ethicist's commentary on buying free-range eggs.
PG  - 464
FAU - Rollin, Bernard E
AU  - Rollin BE
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Vet J
JT  - The Canadian veterinary journal = La revue veterinaire canadienne
JID - 0004653
SB  - IM
MH  - Animal Husbandry/*ethics/methods
MH  - *Animal Welfare
MH  - Animals
MH  - *Breeding
MH  - Chickens/injuries/*physiology
MH  - Eggs
MH  - Humans
MH  - Osteoporotic Fractures/epidemiology/genetics/*veterinary
MH  - Poultry Diseases/*genetics
PMC - PMC3077996
EDAT- 2011/11/02 06:00
MHDA- 2012/01/10 06:00
CRDT- 2011/11/02 06:00
PHST- 2011/11/02 06:00 [entrez]
PHST- 2011/11/02 06:00 [pubmed]
PHST- 2012/01/10 06:00 [medline]
PST - ppublish
SO  - Can Vet J. 2011 May;52(5):464.


PMID- 22043050
OWN - NLM
STAT- MEDLINE
DCOM- 20120319
LR  - 20191210
IS  - 1745-6614 (Electronic)
IS  - 1052-6773 (Linking)
VI  - 2011
IP  - 43
DP  - 2011
TI  - Surrogate markers for targeted therapy-based treatment activity and efficacy.
PG  - 91-4
LID - 10.1093/jncimonographs/lgr024 [doi]
AB  - Predictive biomarkers capable of discriminating individuals who will benefit from
      a given therapy from those who will not are key to personalized medicine. New
      drugs are developed in patients with advanced disease, when ethical and practical
      shortcomings limit the collection of tumor specimens. The neoadjuvant setting
      offers a unique opportunity for overcoming these limitations. Tumor samples are
      collected at diagnosis and posttreatment surgery as part of a routine therapeutic
      approach. Pathological complete response has been consistently associated with
      long-term survival and may be useful as an intermediate endpoint in developing
      and evaluating predictive, as well as surrogate, biomarkers. In
      window-of-opportunity studies, new drugs are administered shortly before planned 
      surgery, and the effect of the intervention can be assessed by comparing
      diagnostic biopsy with the surgical specimen. Until now, clinically useful and
      validated predictive markers for targeted therapy are rare, but appropriate
      investigations in neoadjuvant studies will likely change this.
FAU - Bianchini, Giampaolo
AU  - Bianchini G
AD  - Department of Medical Oncology, hSR-San Raffaele, via Olgettina 60, Milano 20132,
      Italy.
FAU - Gianni, Luca
AU  - Gianni L
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Natl Cancer Inst Monogr
JT  - Journal of the National Cancer Institute. Monographs
JID - 9011255
RN  - 0 (Antibodies, Monoclonal, Humanized)
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Ki-67 Antigen)
RN  - 0 (Phosphoinositide-3 Kinase Inhibitors)
RN  - 0 (Poly(ADP-ribose) Polymerase Inhibitors)
RN  - 0 (Quinazolines)
RN  - 0VUA21238F (Lapatinib)
RN  - P188ANX8CK (Trastuzumab)
SB  - IM
MH  - Antibodies, Monoclonal, Humanized/therapeutic use
MH  - Antineoplastic Agents/*therapeutic use
MH  - Biomarkers, Tumor/*metabolism
MH  - Breast Neoplasms/*drug therapy/*metabolism
MH  - Enzyme Inhibitors/therapeutic use
MH  - Female
MH  - Humans
MH  - Ki-67 Antigen/metabolism
MH  - Lapatinib
MH  - *Molecular Targeted Therapy/methods
MH  - *Neoadjuvant Therapy/methods
MH  - Phosphoinositide-3 Kinase Inhibitors
MH  - Poly(ADP-ribose) Polymerase Inhibitors
MH  - Precision Medicine/methods/trends
MH  - Predictive Value of Tests
MH  - Quinazolines/therapeutic use
MH  - Randomized Controlled Trials as Topic
MH  - Trastuzumab
MH  - Treatment Outcome
MH  - Validation Studies as Topic
EDAT- 2011/11/02 06:00
MHDA- 2012/03/20 06:00
CRDT- 2011/11/02 06:00
PHST- 2011/11/02 06:00 [entrez]
PHST- 2011/11/02 06:00 [pubmed]
PHST- 2012/03/20 06:00 [medline]
AID - lgr024 [pii]
AID - 10.1093/jncimonographs/lgr024 [doi]
PST - ppublish
SO  - J Natl Cancer Inst Monogr. 2011;2011(43):91-4. doi:
      10.1093/jncimonographs/lgr024.


PMID- 22042899
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120105
LR  - 20130424
IS  - 1364-503X (Print)
IS  - 1364-503X (Linking)
VI  - 369
IP  - 1956
DP  - 2011 Dec 13
TI  - Uncertainty in science and its role in climate policy.
PG  - 4818-41
LID - 10.1098/rsta.2011.0149 [doi]
AB  - Policy-making is usually about risk management. Thus, the handling of uncertainty
      in science is central to its support of sound policy-making. There is value in
      scientists engaging in a deep conversation with policy-makers and others, not
      merely 'delivering' results or analyses and then playing no further role.
      Communicating the policy relevance of different varieties of uncertainty,
      including imprecision, ambiguity, intractability and indeterminism, is an
      important part of this conversation. Uncertainty is handled better when
      scientists engage with policy-makers. Climate policy aims both to alter future
      risks (particularly via mitigation) and to take account of and respond to
      relevant remaining risks (via adaptation) in the complex causal chain that begins
      and ends with individuals. Policy-making profits from learning how to shift the
      distribution of risks towards less dangerous impacts, even if the probability of 
      events remains uncertain. Immediate value lies not only in communicating how
      risks may change with time and how those risks may be changed by action, but also
      in projecting how our understanding of those risks may improve with time (via
      science) and how our ability to influence them may advance (via technology and
      policy design). Guidance on the most urgent places to gather information and
      realistic estimates of when to expect more informative answers is of immediate
      value, as are plausible estimates of the risk of delaying action. Risk assessment
      requires grappling with probability and ambiguity (uncertainty in the Knightian
      sense) and assessing the ethical, logical, philosophical and economic
      underpinnings of whether a target of '50 per cent chance of remaining under +2(
      degrees )C' is either 'right' or 'safe'. How do we better stimulate advances in
      the difficult analytical and philosophical questions while maintaining
      foundational scientific work advancing our understanding of the phenomena? And
      provide immediate help with decisions that must be made now?
FAU - Smith, Leonard A
AU  - Smith LA
AD  - Centre for the Analysis of Time Series, London School of Economics, Houghton
      Street, London WC2A 2AE, UK. l.smith@lse.ac.uk
FAU - Stern, Nicholas
AU  - Stern N
LA  - eng
PT  - Journal Article
PL  - England
TA  - Philos Trans A Math Phys Eng Sci
JT  - Philosophical transactions. Series A, Mathematical, physical, and engineering
      sciences
JID - 101133385
EDAT- 2011/11/02 06:00
MHDA- 2011/11/02 06:01
CRDT- 2011/11/02 06:00
PHST- 2011/11/02 06:00 [entrez]
PHST- 2011/11/02 06:00 [pubmed]
PHST- 2011/11/02 06:01 [medline]
AID - 369/1956/4818 [pii]
AID - 10.1098/rsta.2011.0149 [doi]
PST - ppublish
SO  - Philos Trans A Math Phys Eng Sci. 2011 Dec 13;369(1956):4818-41. doi:
      10.1098/rsta.2011.0149.


PMID- 22042708
OWN - NLM
STAT- MEDLINE
DCOM- 20131126
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 1
DP  - 2013 Mar
TI  - Academic integrity in a mandatory physics lab: the influence of post-graduate
      aspirations and grade point averages.
PG  - 219-35
LID - 10.1007/s11948-011-9325-8 [doi]
AB  - Research on academic cheating by high school students and undergraduates suggests
      that many students will do whatever it takes, including violating ethical
      classroom standards, to not be left behind or to race to the top. This behavior
      may be exacerbated among pre-med and pre-health professional school students
      enrolled in laboratory classes because of the typical disconnect between these
      students, their instructors and the perceived legitimacy of the laboratory work. 
      There is little research, however, that has investigated the relationship between
      high aspirations and academic conduct. This study fills this research gap by
      investigating the beliefs, perceptions and self-reported academic conduct of
      highly aspirational students and their peers in mandatory physics labs. The
      findings suggest that physics laboratory classes may face particular challenges
      with highly aspirational students and cheating, but the paper offers practical
      solutions for addressing them.
FAU - Bertram Gallant, Tricia
AU  - Bertram Gallant T
AD  - Academic Integrity Office, University of California, San Diego, La Jolla, CA
      92093-0069, USA. tbg@ucsd.edu
FAU - Anderson, Michael G
AU  - Anderson MG
FAU - Killoran, Christine
AU  - Killoran C
LA  - eng
PT  - Journal Article
DEP - 20111101
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Aspirations, Psychological
MH  - Culture
MH  - *Deception
MH  - Education, Premedical/ethics
MH  - *Educational Measurement
MH  - Educational Status
MH  - Health Occupations/education
MH  - Humans
MH  - *Laboratories
MH  - *Morals
MH  - Perception
MH  - Physics/*education
MH  - Self Report
MH  - *Students/psychology
MH  - Universities
EDAT- 2011/11/02 06:00
MHDA- 2013/12/16 06:00
CRDT- 2011/11/02 06:00
PHST- 2011/08/04 00:00 [received]
PHST- 2011/10/18 00:00 [accepted]
PHST- 2011/11/02 06:00 [entrez]
PHST- 2011/11/02 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1007/s11948-011-9325-8 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Mar;19(1):219-35. doi: 10.1007/s11948-011-9325-8. Epub 2011 
      Nov 1.


PMID- 22041952
OWN - NLM
STAT- MEDLINE
DCOM- 20111221
LR  - 20181201
IS  - 1539-3704 (Electronic)
IS  - 0003-4819 (Linking)
VI  - 155
IP  - 9
DP  - 2011 Nov 1
TI  - Retainer medicine: an ethically legitimate form of practice that can improve
      primary care.
PG  - 633-5
LID - 10.7326/0003-4819-155-9-201111010-00013 [doi]
AB  - Retainer medicine has become an important yet controversial form of primary care 
      practice in the United States, coming under attack for its purported failure to
      measure up to professional ethics. Critics opine that retainer medicine obstructs
      professional commitments to health care access and social justice. Some ethicists
      urge that society should restrict or ban retainer medicine; professional
      organizations have yet to take a stand. The authors believe that retainer
      medicine is compatible with professional ethics and will more likely aid in
      solving the difficulties facing primary care rather than add to them. Although
      professional ethics should evolve to address new conditions, a condemnation of
      retainer medicine is warranted neither by traditional ethical precepts nor by
      contemporary developments in medical ethics. Any move to sanction retainer
      medicine under the banner of professionalism or professional ethics will be
      counterproductive. The primary care shortage will only get worse if physicians in
      retainer practice leave primary care altogether, a likely outcome of legal or
      professional condemnation of retainer practice.
FAU - Huddle, Thomas S
AU  - Huddle TS
AD  - University of Alabama at Birmingham, 35294, USA. thuddle@uab.edu
FAU - Centor, Robert M
AU  - Centor RM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Intern Med
JT  - Annals of internal medicine
JID - 0372351
SB  - IM
CIN - Ann Intern Med. 2011 Nov 1;155(9):641-2. PMID: 22041955
CIN - Ann Intern Med. 2012 Mar 6;156(5):399; author reply 401. PMID: 22393139
CIN - Ann Intern Med. 2012 Mar 6;156(5):399; author reply 401. PMID: 22393140
CIN - Ann Intern Med. 2012 Mar 6;156(5):399-400; author reply 401. PMID: 22393141
CIN - Ann Intern Med. 2012 Mar 6;156(5):400; author reply 401. PMID: 22393142
CIN - Ann Intern Med. 2012 Mar 6;156(5):400-1; author reply 401. PMID: 22393143
MH  - *Ethics, Professional
MH  - *Fees, Medical
MH  - Health Services Accessibility
MH  - Practice Management, Medical/*economics/*ethics
MH  - Primary Health Care/*economics/*ethics
MH  - Social Justice
MH  - United States
MH  - Workforce
EDAT- 2011/11/02 06:00
MHDA- 2011/12/22 06:00
CRDT- 2011/11/02 06:00
PHST- 2011/11/02 06:00 [entrez]
PHST- 2011/11/02 06:00 [pubmed]
PHST- 2011/12/22 06:00 [medline]
AID - 155/9/633 [pii]
AID - 10.7326/0003-4819-155-9-201111010-00013 [doi]
PST - ppublish
SO  - Ann Intern Med. 2011 Nov 1;155(9):633-5. doi:
      10.7326/0003-4819-155-9-201111010-00013.


PMID- 22041704
OWN - NLM
STAT- MEDLINE
DCOM- 20120224
LR  - 20190724
IS  - 1347-5231 (Electronic)
IS  - 0031-6903 (Linking)
VI  - 131
IP  - 11
DP  - 2011
TI  - [Comparison in dissolution behavior of ethical and over-the counter scopolamine
      butylbromide].
PG  - 1645-51
AB  - Marketing authorization holders do not disclose any information on the
      pharmaceutical properties of over-the-counter drugs (OTC). When a drug is
      switched from a prescription drug to OTC, pharmacists can acquire that
      information from the corresponding ethical drug (ED) through the package insert, 
      interview form, and so on. However, the pharmaceutical equivalence between ED and
      OTC is unclear. In this study, we examined the drug dissolution behavior of both 
      ED and OTCs containing scopolamine butylbromide. Dissolution tests were performed
      by the paddle method using Japanese Pharmacopeia (JP) XV test fluids at pH 1.2,
      4.0 and 6.8 and water based on the guidelines for bioequivalence studies of
      generic products. The dissolution profiles of OTCs differed significantly from ED
      showing a similarity factor (f2) value ranging from 8.9 to 42.9. Time until 85%
      dissolution ranged from 23 to 95 min and from 17 to 174 min at pH 1.2 and pH 6.8,
      respectively. Then JP XV disintegration tests were conducted to investigate
      differences in the disintegration process. The disintegration time of
      preparations showing delayed dissolution was prolonged compared to that of
      others, suggesting that the disintegration of the tablet or capsule is one of the
      important factors affecting the drug dissolution. These differences in the
      disintegration and drug dissolution might cause differences in the
      bioavailability of the drug. For patient safety, more detailed product
      information of OTCs should be supplied by the manufacturer, and not be assumed
      from that of corresponding ED.
FAU - Suzuki, Ichie
AU  - Suzuki I
AD  - Department of Clinical Pharmaceutics, School of Pharmaceutical Sciences,
      University of Shizuoka, Shizuoka, Japan.
FAU - Miyazaki, Yasunori
AU  - Miyazaki Y
FAU - Uchino, Tomonobu
AU  - Uchino T
FAU - Kagawa, Yoshiyuki
AU  - Kagawa Y
LA  - jpn
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Yakugaku Zasshi
JT  - Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
JID - 0413613
RN  - 0 (Nonprescription Drugs)
RN  - 0 (Prescription Drugs)
RN  - 059QF0KO0R (Water)
RN  - 2Z3E1OF81V (Butylscopolammonium Bromide)
SB  - IM
MH  - Biological Availability
MH  - *Butylscopolammonium Bromide
MH  - Drug Substitution
MH  - *Nonprescription Drugs
MH  - Patient Safety
MH  - *Prescription Drugs
MH  - Solubility
MH  - Therapeutic Equivalency
MH  - Water
EDAT- 2011/11/02 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/11/02 06:00
PHST- 2011/11/02 06:00 [entrez]
PHST- 2011/11/02 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - JST.JSTAGE/yakushi/131.1645 [pii]
AID - 10.1248/yakushi.131.1645 [doi]
PST - ppublish
SO  - Yakugaku Zasshi. 2011;131(11):1645-51. doi: 10.1248/yakushi.131.1645.


PMID- 22041406
OWN - NLM
STAT- MEDLINE
DCOM- 20120404
LR  - 20190709
IS  - 1943-4723 (Electronic)
IS  - 0002-8177 (Linking)
VI  - 142
IP  - 11
DP  - 2011 Nov
TI  - Ethical referrals.
PG  - 1234; author reply 1234-5
FAU - Knudson, Robert
AU  - Knudson R
AD  - Bellingham, Wash.
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - England
TA  - J Am Dent Assoc
JT  - Journal of the American Dental Association (1939)
JID - 7503060
SB  - IM
CON - J Am Dent Assoc. 2011 Aug;142(8):966-7. PMID: 21804066
MH  - Dentists/*ethics
MH  - *Ethics, Dental
MH  - Humans
MH  - Marketing of Health Services/*ethics
MH  - Practice Management, Dental/*ethics
EDAT- 2011/11/02 06:00
MHDA- 2012/04/05 06:00
CRDT- 2011/11/02 06:00
PHST- 2011/11/02 06:00 [entrez]
PHST- 2011/11/02 06:00 [pubmed]
PHST- 2012/04/05 06:00 [medline]
AID - S0002-8177(14)62802-6 [pii]
AID - 10.14219/jada.archive.2011.0096 [doi]
PST - ppublish
SO  - J Am Dent Assoc. 2011 Nov;142(11):1234; author reply 1234-5. doi:
      10.14219/jada.archive.2011.0096.


PMID- 22040861
OWN - NLM
STAT- MEDLINE
DCOM- 20120330
LR  - 20211020
IS  - 1522-9653 (Electronic)
IS  - 1063-4584 (Linking)
VI  - 20
IP  - 1
DP  - 2012 Jan
TI  - Reproducibility of sodium MRI measures of articular cartilage of the knee in
      osteoarthritis.
PG  - 29-35
LID - 10.1016/j.joca.2011.10.007 [doi]
AB  - OBJECTIVE: To determine the stability and reproducibility of the sodium magnetic 
      resonance imaging (MRI) signal measured in the articular cartilage of the knee in
      both healthy volunteers and osteoarthritis (OA) patients. DESIGN: This was a
      prospective Research Ethics Committee approved study that acquired sodium and
      proton MRI data from 15 subjects with OA (three males, age 64 +/- 10) and five
      healthy controls age and sex matched over the group. Each subject underwent
      standing planar radiographs of their knees for radiological scoring as well as
      symptomatological assessment questionnaires. In two MRI sessions on the same day,
      high resolution double-echo steady state (DESS) and 3D short echo time sodium MRI
      images of the most diseased knee were acquired and co-registered in each session.
      A blinded reader (LT) manually delineated the articular cartilage into four
      discrete regions, and two combined regions, on the DESS images. These regions
      were applied to the sodium images, and a median sodium signal from each reported.
      Within-subject and between-subject coefficients of variation were estimated and
      intraclass correlation coefficients for the healthy control group, OA subject
      group, and all pooled subjects group were calculated. RESULTS: Within-subject
      variability of sodium MRI at 3T was 3.2% overall, and 2.0% in healthy age-matched
      volunteers compared to a reproducibility of 3.6% on OA subjects. CONCLUSIONS: The
      reproducibility of sodium MRI was similar in both healthy controls and OA
      subjects. Researchers piloting techniques in healthy controls thus may expect a
      similar reproducibility in a controlled trial involving subjects with American
      College of Rheumatology (ACR)-defined OA of the knee.
CI  - Copyright (c) 2011 Osteoarthritis Research Society International. Published by
      Elsevier Ltd. All rights reserved.
FAU - Newbould, R D
AU  - Newbould RD
AD  - GSK Clinical Imaging Centre, Hammersmith Hospital, Imperial College London,
      London, UK. rexford.newbould@gmail.com
FAU - Miller, S R
AU  - Miller SR
FAU - Tielbeek, J A W
AU  - Tielbeek JA
FAU - Toms, L D
AU  - Toms LD
FAU - Rao, A W
AU  - Rao AW
FAU - Gold, G E
AU  - Gold GE
FAU - Strachan, R K
AU  - Strachan RK
FAU - Taylor, P C
AU  - Taylor PC
FAU - Matthews, P M
AU  - Matthews PM
FAU - Brown, A P
AU  - Brown AP
LA  - eng
GR  - R01 EB002524/EB/NIBIB NIH HHS/United States
GR  - R01 EB002524-08/EB/NIBIB NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20111019
PL  - England
TA  - Osteoarthritis Cartilage
JT  - Osteoarthritis and cartilage
JID - 9305697
RN  - 0 (Biomarkers)
RN  - 9NEZ333N27 (Sodium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anthropometry/methods
MH  - Biomarkers/metabolism
MH  - Cartilage, Articular/metabolism/*pathology
MH  - Disease Progression
MH  - Epidemiologic Methods
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Osteoarthritis, Knee/*diagnosis
MH  - Reproducibility of Results
MH  - Sodium/*metabolism
PMC - PMC3270258
MID - NIHMS352094
EDAT- 2011/11/02 06:00
MHDA- 2012/03/31 06:00
CRDT- 2011/11/02 06:00
PHST- 2011/07/05 00:00 [received]
PHST- 2011/10/05 00:00 [revised]
PHST- 2011/10/11 00:00 [accepted]
PHST- 2011/11/02 06:00 [entrez]
PHST- 2011/11/02 06:00 [pubmed]
PHST- 2012/03/31 06:00 [medline]
AID - S1063-4584(11)00295-0 [pii]
AID - 10.1016/j.joca.2011.10.007 [doi]
PST - ppublish
SO  - Osteoarthritis Cartilage. 2012 Jan;20(1):29-35. doi: 10.1016/j.joca.2011.10.007. 
      Epub 2011 Oct 19.


PMID- 22040417
OWN - NLM
STAT- MEDLINE
DCOM- 20120501
LR  - 20161125
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Linking)
VI  - 124
IP  - 17
DP  - 2011 Sep
TI  - Intracerebroventricular transplantation of human amniotic epithelial cells
      ameliorates spatial memory deficit in the doubly transgenic mice coexpressing
      APPswe and PS1DeltaE9-deleted genes.
PG  - 2642-8
AB  - BACKGROUND: Human amniotic epithelial cells (HAECs), which have characteristics
      of both embryonic and pluripotent stem cells, are therefore a candidate in cell
      therapy without creating legal or ethical problems. In the present study, we
      aimed to investigate the effects of intracerebroventricular transplantation of
      HAECs on doubly transgenic mice of Alzheimer's disease (AD) coexpressing
      presenilin-1 (PS1) and mutant Sweden amyloid precursor protein (APPswe) genes.
      METHODS: The offspring mice genotypes were detected using PCR identification of
      APPswe and PS1 gene. The doubly transgenic (TG) mice (n = 20) and wild-type (WT) 
      mice (n = 20) were randomly divided into two groups respectively: the
      transplantation group treated with HAECs and the control group with phosphate
      buffered saline. Six radial arm water maze test was used to assess the spatial
      memory in the TG and WT mice. Amyloid plaques and neurofibrillary tangles were
      analyzed using congo red and acid-silver methenamine staining respectively.
      Immunofluorescence cytochemistry was used to track the survival of HAECs.
      Immunohistochemistry was used to determine the expression of octamer-binding
      protein 4 (Oct-4) and Nanog in the HAECs. High performance liquid chromatography 
      was used to measure acetylcholine in hippocampus. The density of cholinergic
      neurons in basal forebrain and nerve fibers in hippocampus was measured using
      acetylcholinesterase staining. RESULTS: Amyloid deposition occurred in
      hippocampus and frontal cortex in the double TG mice aged 8 months, but not in WT
      mice. The results also showed that transplanted HAECs can survive for at least 8 
      weeks and migrate to the third ventricle without immune rejection. The graft
      HAECs can also express the specific marker Oct-4 and Nanog of stem cell. Compared
      with the control group, transplantation of HAECs can not only significantly
      improve the spatial memory of the TG mice, but also increase acetylcholine
      concentration and the number of hippocampal cholinergic neurites. CONCLUSIONS:
      These results demonstrate that intracerebroventricular transplantation of HAECs
      can improve the spatial memory of the double TG mice. The higher content of
      acetylcholine in hippocampus released by more survived cholinergic neurites is
      one of the causes of this improvement.
FAU - Xue, Shou-ru
AU  - Xue SR
AD  - Department of Neurology, First Affiliated Hospital of Soochow University, Suzhou,
      Jiangsu 215006, China.
FAU - Chen, Chong-fang
AU  - Chen CF
FAU - Dong, Wan-li
AU  - Dong WL
FAU - Hui, Guo-zhen
AU  - Hui GZ
FAU - Liu, Tian-jun
AU  - Liu TJ
FAU - Guo, Li-he
AU  - Guo LH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 0 (Amyloid beta-Protein Precursor)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Nanog Homeobox Protein)
RN  - 0 (Nanog protein, mouse)
RN  - 0 (Octamer Transcription Factor-3)
RN  - 0 (Presenilin-1)
RN  - N9YNS0M02X (Acetylcholine)
SB  - IM
MH  - Acetylcholine/metabolism
MH  - Alzheimer Disease/genetics/metabolism/therapy
MH  - Amnion/*cytology
MH  - Amyloid beta-Protein Precursor/genetics/metabolism
MH  - Animals
MH  - Chromatography, High Pressure Liquid
MH  - Epithelial Cells/cytology/*transplantation
MH  - Genotype
MH  - Hippocampus/metabolism
MH  - Homeodomain Proteins/genetics/metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Memory Disorders/genetics/*metabolism/*therapy
MH  - Mice
MH  - Mice, Transgenic
MH  - Nanog Homeobox Protein
MH  - Octamer Transcription Factor-3/genetics/metabolism
MH  - Polymerase Chain Reaction
MH  - Presenilin-1/genetics/metabolism
EDAT- 2011/11/02 06:00
MHDA- 2012/05/02 06:00
CRDT- 2011/11/02 06:00
PHST- 2011/11/02 06:00 [entrez]
PHST- 2011/11/02 06:00 [pubmed]
PHST- 2012/05/02 06:00 [medline]
PST - ppublish
SO  - Chin Med J (Engl). 2011 Sep;124(17):2642-8.


PMID- 22040348
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211020
IS  - 2041-2223 (Electronic)
IS  - 2041-2223 (Linking)
VI  - 2
DP  - 2011 Nov 1
TI  - Policy implications for familial searching.
PG  - 22
LID - 10.1186/2041-2223-2-22 [doi]
AB  - In the United States, several states have made policy decisions regarding whether
      and how to use familial searching of the Combined DNA Index System (CODIS)
      database in criminal investigations. Familial searching pushes DNA typing beyond 
      merely identifying individuals to detecting genetic relatedness, an application
      previously reserved for missing persons identifications and custody battles. The 
      intentional search of CODIS for partial matches to an item of evidence offers law
      enforcement agencies a powerful tool for developing investigative leads,
      apprehending criminals, revitalizing cold cases and exonerating wrongfully
      convicted individuals. As familial searching involves a range of logistical,
      social, ethical and legal considerations, states are now grappling with policy
      options for implementing familial searching to balance crime fighting with its
      potential impact on society. When developing policies for familial searching,
      legislators should take into account the impact of familial searching on select
      populations and the need to minimize personal intrusion on relatives of
      individuals in the DNA database. This review describes the approaches used to
      narrow a suspect pool from a partial match search of CODIS and summarizes the
      economic, ethical, logistical and political challenges of implementing familial
      searching. We examine particular US state policies and the policy options adopted
      to address these issues. The aim of this review is to provide objective
      background information on the controversial approach of familial searching to
      inform policy decisions in this area. Herein we highlight key policy options and 
      recommendations regarding effective utilization of familial searching that
      minimize harm to and afford maximum protection of US citizens.
FAU - Kim, Joyce
AU  - Kim J
AD  - Center for Genome Ethics, Law & Policy, Duke Institute for Genome Sciences &
      Policy, Duke University, Box 90141, Durham, NC 27708, USA.
      sara.katsanis@duke.edu.
FAU - Mammo, Danny
AU  - Mammo D
FAU - Siegel, Marni B
AU  - Siegel MB
FAU - Katsanis, Sara H
AU  - Katsanis SH
LA  - eng
PT  - Journal Article
DEP - 20111101
PL  - England
TA  - Investig Genet
JT  - Investigative genetics
JID - 101546908
PMC - PMC3253037
EDAT- 2011/11/02 06:00
MHDA- 2011/11/02 06:01
CRDT- 2011/11/02 06:00
PHST- 2011/08/26 00:00 [received]
PHST- 2011/11/01 00:00 [accepted]
PHST- 2011/11/02 06:00 [entrez]
PHST- 2011/11/02 06:00 [pubmed]
PHST- 2011/11/02 06:01 [medline]
AID - 2041-2223-2-22 [pii]
AID - 10.1186/2041-2223-2-22 [doi]
PST - epublish
SO  - Investig Genet. 2011 Nov 1;2:22. doi: 10.1186/2041-2223-2-22.


PMID- 22040269
OWN - NLM
STAT- MEDLINE
DCOM- 20120508
LR  - 20131121
IS  - 1365-3164 (Electronic)
IS  - 0959-4493 (Linking)
VI  - 23
IP  - 1
DP  - 2012 Feb
TI  - Protective effects of phlorotannins against ultraviolet B radiation in zebrafish 
      (Danio rerio).
PG  - 51-6, e12
LID - 10.1111/j.1365-3164.2011.01009.x [doi]
AB  - Exposure to ultraviolet B (UV-B) radiation has been associated with a variety of 
      adverse effects in all forms of life, including micro-organisms, plants, animals 
      and humans. Ultraviolet B induces cell damage at the molecular level and
      consequently organisms must employ strategies to protect themselves from sunlight
      and to repair UV-B-induced cellular damage. In this study, the UV-B protective
      effects of four different phlorotannins isolated from a brown alga (Ecklonia
      cava) were determined using zebrafish (Danio rerio) as an in vivo model.
      Zebrafish embryos were pretreated with phlorotannins and exposed to UV-B (50
      mJ/cm(2)). The heart rate, generation of reactive oxygen species and nitric
      oxide, cell death and hyperpigmentation were assessed in order to evaluate
      UV-B-induced photo-damage. Treatment of the embryos with the algal phorotannins
      reduced UV-B-induced reactive oxygen species and nitric oxide levels, protected
      against UV-B-induced cell death and significantly reduced hyperpigmentation. We
      therefore suggest that phlorotannins isolated from E. cava can protect against
      UV-B radiation. Editor Note. Readers of the journal may be unfamiliar with the
      use of zebrafish embryos in research studies. There is no indication in this
      article of an ethical review of the study. This is because the use of fish
      embryos in research, at least in the UK, is not subject to a licensing procedure 
      if they are less than 5 days post fertilization (dpf). In this study the embryos 
      were 2 dpf.
CI  - (c) 2011 The Authors. Veterinary Dermatology (c) 2011 ESVD and ACVD.
FAU - Cha, Seon-Heui
AU  - Cha SH
AD  - School of Biology, Georgia Institute of Technology, Atlanta, GA 30318, USA.
FAU - Ko, Chang-Ik
AU  - Ko CI
FAU - Kim, Daekyung
AU  - Kim D
FAU - Jeon, You-Jin
AU  - Jeon YJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111101
PL  - England
TA  - Vet Dermatol
JT  - Veterinary dermatology
JID - 9426187
RN  - 0 (Antioxidants)
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Tannins)
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - IM
MH  - Animals
MH  - Antioxidants/*pharmacology
MH  - Cell Death/drug effects
MH  - Embryo, Nonmammalian/drug effects/*radiation effects
MH  - Hyperpigmentation/prevention & control
MH  - Nitric Oxide/metabolism
MH  - Phaeophyta/*chemistry
MH  - Radiation Injuries, Experimental/prevention & control
MH  - Reactive Oxygen Species/metabolism
MH  - Tannins/*pharmacology
MH  - Ultraviolet Rays/*adverse effects
MH  - *Zebrafish
EDAT- 2011/11/02 06:00
MHDA- 2012/05/09 06:00
CRDT- 2011/11/02 06:00
PHST- 2011/11/02 06:00 [entrez]
PHST- 2011/11/02 06:00 [pubmed]
PHST- 2012/05/09 06:00 [medline]
AID - 10.1111/j.1365-3164.2011.01009.x [doi]
PST - ppublish
SO  - Vet Dermatol. 2012 Feb;23(1):51-6, e12. doi: 10.1111/j.1365-3164.2011.01009.x.
      Epub 2011 Nov 1.


PMID- 22040240
OWN - NLM
STAT- MEDLINE
DCOM- 20120227
LR  - 20120307
IS  - 1540-9597 (Electronic)
IS  - 0276-3869 (Linking)
VI  - 30
IP  - 4
DP  - 2011
TI  - The plagiarism project.
PG  - 337-48
LID - 10.1080/02763869.2011.609030 [doi]
AB  - Plagiarism has been a problem plaguing academia for centuries. The Internet has
      made it easier than ever to copy material from one electronic document and paste 
      it into another. Many cases are unintentional, as writers are unaware of the
      rules regarding plagiarism. This paper provides an overview of plagiarism and
      describes a project in which librarians partnered with the assistant dean of a
      graduate science program to educate students about the perils of plagiarism and
      encourage ethical writing practices.
FAU - Glassman, Nancy R
AU  - Glassman NR
AD  - D. Samuel Gottesman Library, Albert Einstein College of Medicine of Yeshiva
      University, Bronx, New York, USA. nancy.glassman@einstein.yu.edu
FAU - Sorensen, Karen
AU  - Sorensen K
FAU - Habousha, Racheline G
AU  - Habousha RG
FAU - Minuti, Aurelia
AU  - Minuti A
FAU - Schwartz, Rachel
AU  - Schwartz R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Ref Serv Q
JT  - Medical reference services quarterly
JID - 8219208
MH  - Cooperative Behavior
MH  - *Curriculum
MH  - Ethics
MH  - Librarians
MH  - New York City
MH  - *Plagiarism
MH  - Students, Medical
EDAT- 2011/11/02 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/11/02 06:00
PHST- 2011/11/02 06:00 [entrez]
PHST- 2011/11/02 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - 10.1080/02763869.2011.609030 [doi]
PST - ppublish
SO  - Med Ref Serv Q. 2011;30(4):337-48. doi: 10.1080/02763869.2011.609030.


PMID- 22040137
OWN - NLM
STAT- MEDLINE
DCOM- 20120403
LR  - 20120612
IS  - 1132-1989 (Print)
IS  - 1132-1989 (Linking)
VI  - 22
IP  - 75
DP  - 2011 May-Aug
TI  - [Select embryos: preimplantation genetic diagnosis].
PG  - 243-58
AB  - The ability to detect chromosomal or genetic defects in embryos in vitro,
      associated with assisted human reproduction techniques before his possible
      transfer to the uterus to complete its development was presented as an
      alternative to eugenic abortion. And an option for older women to procreate, to
      avoid pregnancy of embryos with chromosomal defects. Genetic diagnosis before
      implantation (PGD) and screening of embryos in vitro (by the acronym, PSC),
      offers the image of the disabled person as an individual excluded from society.
      It assumes a direct human experimentation without therapeutic purposes or to
      manipulate the embryo that is chosen or discarded according to diagnosis or for
      advancement in perinatal medicine. Because these techniques can have multiple
      embryos, eugenics has also generated a ''positive eugenics'' that seeks to select
      embryos according to a third party, having certain characteristics, sex, or lack 
      of predisposition to disease. Several issues demand unavoidable ethical duty to
      report on this form of eugenics, in addition to be directly and intentionally
      directed to destroy human life in its early stages, and does not meet the minimum
      requirements of rigorous scientific research or biotechnology. There have been no
      previous animal tests to validate the techniques so that there are serious errors
      in diagnosis with false positives and false negatives. Recently it has been shown
      that some discarded embryos can eliminate their detected defects two days after
      the biopsy. Moreover, the study about what may or may not be diagnosed is
      retrospective and unrecoverable damage. And, of particular importance is the fact
      that it is not known with certainty the effects that an embryo biopsy may cause
      to those diagnosed.
FAU - Lopez Moratalla, Natalia
AU  - Lopez Moratalla N
AD  - Dpto. de Bioquimica y Biologia Molecular. Universidad de Navarra.
      natalialm@unav.es
FAU - Lago Fernandez Puron, Marta
AU  - Lago Fernandez Puron M
FAU - Santiago, Esteban
AU  - Santiago E
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Seleccion de Embriones Humanos. Diagnostico Genetico Preimplantacion.
PL  - Spain
TA  - Cuad Bioet
JT  - Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y
      Etica Medica
JID - 101312976
SB  - IM
MH  - Biopsy/adverse effects
MH  - Female
MH  - Fertilization in Vitro
MH  - Humans
MH  - Pregnancy
MH  - *Preimplantation Diagnosis/methods/standards
MH  - Sex Preselection
EDAT- 2011/11/02 06:00
MHDA- 2012/04/04 06:00
CRDT- 2011/11/02 06:00
PHST- 2011/05/05 00:00 [received]
PHST- 2011/06/09 00:00 [accepted]
PHST- 2011/11/02 06:00 [entrez]
PHST- 2011/11/02 06:00 [pubmed]
PHST- 2012/04/04 06:00 [medline]
PST - ppublish
SO  - Cuad Bioet. 2011 May-Aug;22(75):243-58.


PMID- 22040136
OWN - NLM
STAT- MEDLINE
DCOM- 20120403
LR  - 20191210
IS  - 1132-1989 (Print)
IS  - 1132-1989 (Linking)
VI  - 22
IP  - 75
DP  - 2011 May-Aug
TI  - [Proposals for social policies to improve the quality of life in attention
      deficit/hyperactivity disorder [ADHD]].
PG  - 215-42
AB  - This article describes the effects of pre and postnatal stress on the cerebral
      morphological findings described as attention deficit/hyperactivity disorder.
      [ADHD]. The consequences of ADHD cause social problems because these children
      have difficulties with family, school and social integration. Previous treatments
      are reviewed up to the present day. The drug that has been used most frequently
      is Metilphenidate, a psychostimulant, and recently, a new drug, Atomoxetine, a
      non psychostimulant was introduced. The therapy is combined with physiological
      training. These drugs give relief to the symptoms but their long term
      side-effects are unknown. Recent investigations have shown that children with
      ADHD who are receiving either cognitive or control training have increased
      cerebral activity without previous medication. With these facts in mind the
      European ADHD Guidelines group suggests a new focus of attention on the children 
      and adults with this problem with the aim of modifying the treatment followed
      until now. The ethical motives for this review are: a) to make society more aware
      of the problems of ADHD with the aim of taking measures to avoid the possible
      causes of the illness; b) to take into account that the effects of long term
      psychostimulant drugs on the developing mind are unknown; c) to gather
      information that supports the view that diagnosis of ADHD has increased.
FAU - Cid Foix, Ana
AU  - Cid Foix A
AD  - Pediatra de Atencion Primaria, Osakidetza-Servicio Vasco de Salud., Bilbao.
      ana.cidfoix@osakidetza.net
LA  - spa
PT  - Journal Article
PT  - Review
TT  - Propuestas de Politicas Sociales con el Objetivo de Mejorar la Calidad de Vida en
      el Trastorno por Deficit de Atencion e Hiperactividad.
PL  - Spain
TA  - Cuad Bioet
JT  - Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y
      Etica Medica
JID - 101312976
SB  - IM
MH  - *Attention Deficit Disorder with Hyperactivity/complications/psychology/therapy
MH  - Humans
MH  - Learning Disabilities/etiology
MH  - *Public Policy
MH  - *Quality of Life
MH  - Stress, Physiological
MH  - Stress, Psychological/etiology
EDAT- 2011/11/02 06:00
MHDA- 2012/04/04 06:00
CRDT- 2011/11/02 06:00
PHST- 2011/02/25 00:00 [received]
PHST- 2011/04/05 00:00 [accepted]
PHST- 2011/11/02 06:00 [entrez]
PHST- 2011/11/02 06:00 [pubmed]
PHST- 2012/04/04 06:00 [medline]
PST - ppublish
SO  - Cuad Bioet. 2011 May-Aug;22(75):215-42.


PMID- 22040134
OWN - NLM
STAT- MEDLINE
DCOM- 20120403
LR  - 20120612
IS  - 1132-1989 (Print)
IS  - 1132-1989 (Linking)
VI  - 22
IP  - 75
DP  - 2011 May-Aug
TI  - [Estrogens and feminine brain maturation during adolescence: emergency
      contraceptive pill].
PG  - 185-200
AB  - In the period between puberty and maturity takes place the process of brain
      maturation. Hormone levels induce changes in neurons and direct the architecture 
      and structural functionality thus affecting patterns of development of different 
      brain areas. The onset of puberty brings with it the invasion of the female brain
      by high levels of hormones, cyclic surges of estrogen and progesterone in
      addition to steroids produced in situ. Control centers of emotions (amygdala),
      memory and learning (hippocampus) and sexual activity (hypothalamus) are modified
      according to the cyclical concentrations of both hormones. Sex hormones stimulate
      multimodal actions, both short and longer terms, because neurons in various brain
      areas have different types of receptors, membrane, cytoplasmic and nuclear. The
      composition of emergency contraceptive pill (postcoital pill) with high hormonal 
      content raises the urgency of a thorough knowledge about the possible effect that
      the lack of control of the menstrual cycle in a time of consolidation of brain
      maturation, can bring in structuring and development of brain circuitry. Changes 
      in the availability of sex steroids during puberty and adolescence underlie
      psychiatric disorders whose prevalence is typically feminine, such as depression,
      anxiety disorders. It is a fundamental ethical duty to present scientific data
      about the influence of estrogen in young female brain maturation, both for full
      information to potential users, and also to induce the appropriate public health 
      measures.
FAU - Lopez Moratalla, Natalia
AU  - Lopez Moratalla N
AD  - Dpto. de Bioquimica y Biologia Molecular. Universidad de Navarra.
      natalialm@unav.es
FAU - Errasti Alcala, Tania
AU  - Errasti Alcala T
FAU - Santiago, Esteban
AU  - Santiago E
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Estrogenos y Desarrollo del Cerebro Femenino en la Adolescencia: Anticoncepcion
      de Emergencia.
PL  - Spain
TA  - Cuad Bioet
JT  - Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y
      Etica Medica
JID - 101312976
RN  - 0 (Contraceptives, Postcoital)
RN  - 0 (Estrogens)
RN  - EC 1.14.14.1 (Aromatase)
SB  - IM
MH  - Adolescent
MH  - Amygdala/physiology
MH  - Aromatase/physiology
MH  - Brain/*drug effects/*growth & development
MH  - Contraceptives, Postcoital/*pharmacology
MH  - Emotions
MH  - Estrogens/*physiology
MH  - Female
MH  - Hippocampus/physiology
MH  - Humans
MH  - Hypothalamus/physiology
MH  - Puberty/physiology
MH  - Synapses/physiology
EDAT- 2011/11/02 06:00
MHDA- 2012/04/04 06:00
CRDT- 2011/11/02 06:00
PHST- 2011/04/27 00:00 [received]
PHST- 2011/06/02 00:00 [accepted]
PHST- 2011/11/02 06:00 [entrez]
PHST- 2011/11/02 06:00 [pubmed]
PHST- 2012/04/04 06:00 [medline]
PST - ppublish
SO  - Cuad Bioet. 2011 May-Aug;22(75):185-200.


PMID- 22040132
OWN - NLM
STAT- MEDLINE
DCOM- 20120403
LR  - 20191210
IS  - 1132-1989 (Print)
IS  - 1132-1989 (Linking)
VI  - 22
IP  - 75
DP  - 2011 May-Aug
TI  - [Retraction of papers in bioethics: proposal for a paradigmatic case].
PG  - 151-67
AB  - The phenomenon of ethically deficient publication in the field of bioethics is
      practically unknown. In contrast to the numerous articles and regulations on the 
      ethics of biomedical publications, there is a practical absence of articles
      devoted to consider the nature, types and prevalence of ethically defective
      publications in the bioethical literature. No regulatory framework for
      misbehavior in this field has been proposed until now. Certainly, this is a
      difficult subject. On one side, it is not easy to draw the ethical limits of the 
      freedoms of thought and expression in bioethics, a discipline that flourishes in 
      the open debate of principles, norms, cases, and imaginary scenarios, where the
      boundaries between rhetoric and misrepresentation are frequently blurred. After
      showing some examples of minor violations taken from the literature, the author
      deals with the moral duty to retract fraudulent bioethical articles, especially
      when they include deliberate distortions of the data or conclusions from
      published biomedical research. A detailed analysis of a fraudulent article is
      made (Haring B. ''New Dimensions of Responsible Parenthood. '' Theological
      Studies 37, (1976), 120-132), in which an almost systematic distortion of data
      and opinions of the cited literature has been made. The article, published in a
      time of intense and critical protest against the encyclical Humanae vitae,
      pretends to condemn the methods of natural family planning, the only acceptable
      means to the Pope, on the allegation that those methods were harmful for the
      embryo and fetus. According to the author, the retraction of Haring's article is 
      necessary.
FAU - Herranz Rodriguez, Gonzalo
AU  - Herranz Rodriguez G
AD  - Departamento de Humanidades Biomedicas. Universidad de Navarra. Pamplona.
      gherranz@unav.es
LA  - spa
PT  - Journal Article
TT  - Retractacion de Articulos en Bioetica: Propuesta de un Caso Paradigmatico.
PL  - Spain
TA  - Cuad Bioet
JT  - Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y
      Etica Medica
JID - 101312976
SB  - IM
MH  - Abortion, Spontaneous
MH  - Bibliographies as Topic
MH  - *Bioethics
MH  - Chromosome Aberrations
MH  - Female
MH  - Humans
MH  - Natural Family Planning Methods/ethics
MH  - Publishing/*ethics
MH  - *Retraction of Publication as Topic
MH  - Scientific Misconduct
MH  - Zygote
EDAT- 2011/11/02 06:00
MHDA- 2012/04/04 06:00
CRDT- 2011/11/02 06:00
PHST- 2011/06/14 00:00 [received]
PHST- 2011/07/28 00:00 [accepted]
PHST- 2011/11/02 06:00 [entrez]
PHST- 2011/11/02 06:00 [pubmed]
PHST- 2012/04/04 06:00 [medline]
PST - ppublish
SO  - Cuad Bioet. 2011 May-Aug;22(75):151-67.


PMID- 22040131
OWN - NLM
STAT- MEDLINE
DCOM- 20120403
LR  - 20120612
IS  - 1132-1989 (Print)
IS  - 1132-1989 (Linking)
VI  - 22
IP  - 75
DP  - 2011 May-Aug
TI  - [Biomedical update in bioethics: a primordial ethical imperative].
PG  - 141-50
AB  - In this brief article we continue our reflection about the relations that should 
      exist between the knowledge of biomedical sciences and the development of
      bioethics. After stating the principle of not absolute concordance between
      empirical and philosophical data as well as the former data are partial truths
      and highly contextualized by the experiment, we propose a certain criteria that
      should govern the use of biomedical sciences in bioethics. These criteria are
      based on ability to distinguish the two areas of knowledge and, without confusing
      each other, achieve their integration in a new unit of knowledge. Approximating
      the two disciplines in this way each will be more able to accommodate the other. 
      From contiguity to integration into a higher order unit, without that both losing
      their own nature. We conclude that not only this posture avoid the mistake of
      deducting the bioethics from experimental scientific date but also not to
      manipulate biomedical data based on previous philosophical positions. Furthermore
      we also reached a more comprehensive and real understanding of bioethics. This
      implies that both scientists and humanists that work in bioethics must live an
      ethical imperative in their research that we have described as essential. This
      consist in a continuously update in biomedicine for research and development the 
      bioethics.
FAU - Pastor, Luis Miguel
AU  - Pastor LM
AD  - Departamento de Biologia Celular e Histologia. Universidad de Murcia. Campus de
      Espinardo, Espana. bioetica@um.es
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Actualizacion Biomedica en Bioetica: un Imperativo Etico Primordial.
PL  - Spain
TA  - Cuad Bioet
JT  - Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y
      Etica Medica
JID - 101312976
SB  - IM
MH  - *Bioethics
MH  - Philosophy
MH  - Science/ethics
EDAT- 2011/11/02 06:00
MHDA- 2012/04/04 06:00
CRDT- 2011/11/02 06:00
PHST- 2011/07/02 00:00 [received]
PHST- 2011/08/10 00:00 [accepted]
PHST- 2011/11/02 06:00 [entrez]
PHST- 2011/11/02 06:00 [pubmed]
PHST- 2012/04/04 06:00 [medline]
PST - ppublish
SO  - Cuad Bioet. 2011 May-Aug;22(75):141-50.


PMID- 22040110
OWN - NLM
STAT- MEDLINE
DCOM- 20120423
LR  - 20181201
IS  - 1477-2566 (Electronic)
IS  - 1465-3249 (Linking)
VI  - 14
IP  - 1
DP  - 2012 Jan
TI  - Placental mesenchymal stromal cells induced into neurotrophic factor-producing
      cells protect neuronal cells from hypoxia and oxidative stress.
PG  - 45-55
LID - 10.3109/14653249.2011.613928 [doi]
AB  - BACKGROUND AIMS: Mesenchymal stromal cells (MSC) may be useful in a range of
      clinical applications. The placenta has been suggested as an abundant, ethically 
      acceptable, less immunogenic and easily accessible source of MSC. The aim of this
      study was to evaluate the capacity of induced placental MSC to differentiate into
      neurotrophic factor-producing cells (NTF) and their protective effect on neuronal
      cells. METHODS: MSC were isolated from placentas and characterized by
      fluorescence-activated cell sorting (FACS). The cells underwent an induction
      protocol to differentiate them into NTF. Analysis of the cellular differentiation
      was done using polymerase chain reactions (PCR), immunocytochemical staining and 
      enzyme-linked immunosorbent assays (ELISA). Conditioned media from placental MSC 
      (PL-MSC) and differentiated MSC (PL-DIFF) were collected and examined for their
      ability to protect neural cells. RESULTS: The immunocytochemical studies showed
      that the cells displayed typical MSC membrane markers. The cells differentiated
      into osteoblasts and adipocytes. PCR and immunohistology staining demonstrated
      that the induced cells expressed typical astrocytes markers and neurotrophic
      factors. Vascular endothelial growth factor (VEGF) levels were higher in the
      conditioned media from PL-DIFF compared with PL-MSC, as indicated by ELISA. Both 
      PL-DIFF and PL-MSC conditioned media markedly protected neural cells from
      oxidative stress induced by H(2)O(2) and 6-hydroxydopamine. PL-DIFF conditioned
      medium had a superior effect on neuronal cell survival. Anti-VEGF antibodies
      (Bevacizumab) reduced the protective effect of the conditioned media from
      differentiated and undifferentiated MSC. CONCLUSIONS: This study has demonstrated
      a neuroprotective effect of MSC of placental origin subjected to an induction
      differentiation protocol. These data offer the prospect of using placenta as a
      source for stem cell-based therapies.
FAU - Yust-Katz, Shlomit
AU  - Yust-Katz S
AD  - Department of Neurology, Hospital for Women, Rabin Medical Center, Petah Tiqwa
      49100, Israel. liorshlomit@yahoo.com
FAU - Fisher-Shoval, Yonit
AU  - Fisher-Shoval Y
FAU - Barhum, Yael
AU  - Barhum Y
FAU - Ben-Zur, Tali
AU  - Ben-Zur T
FAU - Barzilay, Ran
AU  - Barzilay R
FAU - Lev, Nirit
AU  - Lev N
FAU - Hod, Moshe
AU  - Hod M
FAU - Melamed, Eldad
AU  - Melamed E
FAU - Offen, Daniel
AU  - Offen D
LA  - eng
PT  - Journal Article
DEP - 20111031
PL  - England
TA  - Cytotherapy
JT  - Cytotherapy
JID - 100895309
RN  - 0 (Culture Media, Conditioned)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - BBX060AN9V (Hydrogen Peroxide)
SB  - IM
MH  - Cell Differentiation/drug effects
MH  - Cell Hypoxia
MH  - Cell Separation
MH  - Cells, Cultured
MH  - Culture Media, Conditioned/pharmacology
MH  - Female
MH  - Humans
MH  - Hydrogen Peroxide/metabolism
MH  - Immunohistochemistry
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Mesenchymal Stem Cells/drug effects/*metabolism
MH  - Nerve Growth Factors/*biosynthesis
MH  - Neurons/drug effects/*metabolism
MH  - *Oxidative Stress
MH  - Placenta/*cytology
MH  - Pregnancy
MH  - Vascular Endothelial Growth Factor A/immunology/metabolism
EDAT- 2011/11/02 06:00
MHDA- 2012/04/24 06:00
CRDT- 2011/11/02 06:00
PHST- 2011/11/02 06:00 [entrez]
PHST- 2011/11/02 06:00 [pubmed]
PHST- 2012/04/24 06:00 [medline]
AID - 10.3109/14653249.2011.613928 [doi]
AID - S1465-3249(12)70613-8 [pii]
PST - ppublish
SO  - Cytotherapy. 2012 Jan;14(1):45-55. doi: 10.3109/14653249.2011.613928. Epub 2011
      Oct 31.


PMID- 22040017
OWN - NLM
STAT- MEDLINE
DCOM- 20120217
LR  - 20220317
IS  - 1471-227X (Electronic)
IS  - 1471-227X (Linking)
VI  - 11
DP  - 2011 Oct 31
TI  - Be careful with triage in emergency departments: interobserver agreement on 1,578
      patients in France.
PG  - 19
LID - 10.1186/1471-227X-11-19 [doi]
AB  - BACKGROUND: For several decades, emergency departments (EDs) utilization has
      increased, inducing ED overcrowding in many countries. This phenomenon is related
      partly to an excessive number of nonurgent patients. To resolve ED overcrowding
      and to decrease nonurgent visits, the most common solution has been to triage the
      ED patients to identify potentially nonurgent patients, i.e. which could have
      been dealt with by general practitioner. The objective of this study was to
      measure agreement among ED health professionals on the urgency of an ED visit,
      and to determine if the level of agreement is consistent among different
      sub-groups based on following explicit criteria: age, medical status, type of
      referral to the ED, investigations performed in the ED, and the discharge from
      the ED. METHODS: We conducted a multicentric cross-sectional study to compare
      agreement between nurses and physicians on categorization of ED visits into
      urgent or nonurgent. Subgroups stratified by criteria characterizing the ED visit
      were analyzed in relation to the outcome of the visit. RESULTS: Of 1,928 ED
      patients, 350 were excluded because data were lacking. The overall
      nurse-physician agreement on categorization was moderate (kappa = 0.43). The
      levels of agreement within all subgroups were variable and low. The highest
      agreement concerned three subgroups of complaints: cranial injury (kappa = 0.61),
      gynaecological (kappa = 0.66) and toxicology complaints (kappa = 1.00). The
      lowest agreement concerned two subgroups: urinary-nephrology (kappa = 0.09) and
      hospitalization (kappa = 0.20). When categorization of ED visits into urgent or
      nonurgent cases was compared to hospitalization, ED physicians had higher
      sensitivity and specificity than nurses (respectively 94.9% versus 89.5%, and
      43.1% versus 30.9%). CONCLUSIONS: The lack of physician-nurse agreement and the
      inability to predict hospitalization have important implications for patient
      safety. When urgency screening is used to determine treatment priority,
      disagreement might not matter because all patients in the ED are seen and
      treated. But using assessments as the basis for refusal of care to potential
      nonurgent patients raises legal, ethical, and safety issues. Managed care
      organizations should be cautious when applying such criteria to restrict access
      to EDs.
FAU - Durand, Anne-Claire
AU  - Durand AC
AD  - Laboratoire de Sante Publique, Faculte de Medecine, Equipe de recherche EA 3279
      Evaluation hospitaliere-Mesure de la sante percue, Marseille, France.
      anne-claire.durand@ap-hm.fr
FAU - Gentile, Stephanie
AU  - Gentile S
FAU - Gerbeaux, Patrick
AU  - Gerbeaux P
FAU - Alazia, Marc
AU  - Alazia M
FAU - Kiegel, Pierre
AU  - Kiegel P
FAU - Luigi, Stephane
AU  - Luigi S
FAU - Lindenmeyer, Eric
AU  - Lindenmeyer E
FAU - Olivier, Philippe
AU  - Olivier P
FAU - Hidoux, Marie-Annick
AU  - Hidoux MA
FAU - Sambuc, Roland
AU  - Sambuc R
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20111031
PL  - England
TA  - BMC Emerg Med
JT  - BMC emergency medicine
JID - 100968543
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Emergencies/*classification
MH  - Emergency Nursing/*statistics & numerical data
MH  - *Emergency Service, Hospital
MH  - Female
MH  - France
MH  - Hospitalization
MH  - Hospitals, Rural
MH  - Hospitals, Teaching
MH  - Hospitals, Urban
MH  - Humans
MH  - Male
MH  - Medical Staff, Hospital/*statistics & numerical data
MH  - Middle Aged
MH  - Observer Variation
MH  - ROC Curve
MH  - Triage/*statistics & numerical data
MH  - Young Adult
PMC - PMC3215166
EDAT- 2011/11/02 06:00
MHDA- 2012/02/18 06:00
CRDT- 2011/11/02 06:00
PHST- 2011/01/26 00:00 [received]
PHST- 2011/10/31 00:00 [accepted]
PHST- 2011/11/02 06:00 [entrez]
PHST- 2011/11/02 06:00 [pubmed]
PHST- 2012/02/18 06:00 [medline]
AID - 1471-227X-11-19 [pii]
AID - 10.1186/1471-227X-11-19 [doi]
PST - epublish
SO  - BMC Emerg Med. 2011 Oct 31;11:19. doi: 10.1186/1471-227X-11-19.


PMID- 22039729
OWN - NLM
STAT- MEDLINE
DCOM- 20111229
LR  - 20111101
IS  - 0035-2640 (Print)
IS  - 0035-2640 (Linking)
VI  - 61
IP  - 7
DP  - 2011 Sep
TI  - [Specific care plan in different stages of Alzheimer's disease].
PG  - 931-6
AB  - The management and follow-up of patients with Alzheimers disease have
      stage-specific characteristics. In the mild stage, the key challenges are above
      all to improve the early diagnosis and the communication of the diagnosis. With
      the patient's agreement, a follow-up should be scheduled to assess, at each stage
      of the disease, cognitive and functional decline, and detect psycho-behavioral,
      nutritional or mobility complications. In the moderate or severe stages,
      prevention and treatment of caregiver burnout should be included in the
      follow-up. Finally, in the very severe stage, end of life and ethical issues
      should be considered. The followup and the intervention plan should be adapted to
      each patient, and require coordination between health care professionals and
      social workers. However, the practical aspects of the follow-up and the ways in
      which those can be improved are yet to be defined.
FAU - Hein, Christophe
AU  - Hein C
AD  - Gerontopole, service de medecine interne geriatrique, CHU de Toulouse, hopital
      Casselardit, 31300 Toulouse.
FAU - Villars, Helene
AU  - Villars H
FAU - Nourhashemi, Fati
AU  - Nourhashemi F
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Specificites du plan d'aide et de soins aux differents stades des maladies
      d'Alzheimer.
PL  - France
TA  - Rev Prat
JT  - La Revue du praticien
JID - 0404334
SB  - IM
MH  - Alzheimer Disease/*therapy
MH  - Humans
MH  - *Patient Care Planning
MH  - *Severity of Illness Index
EDAT- 2011/11/02 06:00
MHDA- 2011/12/30 06:00
CRDT- 2011/11/02 06:00
PHST- 2011/11/02 06:00 [entrez]
PHST- 2011/11/02 06:00 [pubmed]
PHST- 2011/12/30 06:00 [medline]
PST - ppublish
SO  - Rev Prat. 2011 Sep;61(7):931-6.


PMID- 22027921
OWN - NLM
STAT- MEDLINE
DCOM- 20120214
LR  - 20111026
IS  - 1460-2237 (Electronic)
IS  - 0268-1080 (Linking)
VI  - 26 Suppl 2
DP  - 2011 Nov
TI  - The sudden removal of user fees: the perspective of a frontline manager in
      Burundi.
PG  - ii63-71
LID - 10.1093/heapol/czr061 [doi]
AB  - In May 2006, the President of Burundi announced the removal of user fees in all
      health centres and hospitals for children under 5 and women giving birth. As
      other studies also point out, the policy was adopted extremely suddenly, without 
      much reflection on its ultimate aims and on the operational dimension of its
      implementation. From the perspective of a frontline manager, this paper provides 
      a descriptive case study of the abolition of user fees in the Muramvya District
      and a first-hand account of the effects of the sudden reform in the management of
      a district and a district hospital. The analysis highlights the challenges that
      the district and hospital teams faced. The main issues were: the reduction of
      financial flows, which prevented the possibility of investments and caused
      frequent drugs stock-outs; the reduced quality of the services and the disruption
      of the referral system; the motivation of the health staff who saw the
      administrative workload increase (not necessarily because of increased
      utilization) and faced 'ethical dilemmas' caused by the imprecise targeting of
      the reform. Undoubtedly, the removal of user fees for certain groups was an
      equitable and necessary measure in an extremely poor country such as Burundi.
      However, the suddenness of the decision and the lack of preparation had critical 
      and long-lasting consequences for the entire health system. This analysis,
      performed from the frontline perspective, clarifies the importance of a rigorous 
      planning of any reform, as well as of involving peripheral actors and
      understanding the complex challenges that they face.
FAU - Nimpagaritse, Manasse
AU  - Nimpagaritse M
AD  - Ministry of Public Health, Bujumbura, Burundi. mnimpagaritse@yahoo.fr
FAU - Bertone, Maria Paola
AU  - Bertone MP
LA  - eng
PT  - Journal Article
PL  - England
TA  - Health Policy Plan
JT  - Health policy and planning
JID - 8610614
MH  - Burundi
MH  - *Fees and Charges
MH  - Health Services Accessibility/*economics
MH  - Humans
MH  - Organizational Case Studies
MH  - *Public Policy
EDAT- 2011/11/02 06:00
MHDA- 2012/02/15 06:00
CRDT- 2011/10/27 06:00
PHST- 2011/10/27 06:00 [entrez]
PHST- 2011/11/02 06:00 [pubmed]
PHST- 2012/02/15 06:00 [medline]
AID - czr061 [pii]
AID - 10.1093/heapol/czr061 [doi]
PST - ppublish
SO  - Health Policy Plan. 2011 Nov;26 Suppl 2:ii63-71. doi: 10.1093/heapol/czr061.


PMID- 22039585
OWN - NLM
STAT- MEDLINE
DCOM- 20120308
LR  - 20111122
IS  - 1468-6244 (Electronic)
IS  - 0022-2593 (Linking)
VI  - 48
IP  - 12
DP  - 2011 Dec
TI  - Pathogenic aberrations revealed exclusively by single nucleotide polymorphism
      (SNP) genotyping data in 5000 samples tested by molecular karyotyping.
PG  - 831-9
LID - 10.1136/jmedgenet-2011-100372 [doi]
AB  - BACKGROUND: Several recent studies have demonstrated the use of single nucleotide
      polymorphism (SNP) arrays for the investigation of intellectual disability,
      developmental delay, autism or congenital abnormalities. In addition to LogR
      'copy number' data, these arrays provide SNP genotyping data for gene level
      autozygosity mapping, estimating low levels of mosaicism, assessing long
      continuous stretches of homozygosity (LCSH), detection of uniparental disomy, and
      'autozygous' regions. However, there remains little specific information on the
      clinical utility of this genotyping data. METHODS: Molecular karyotyping, using
      SNP array, was performed on 5000 clinical samples. RESULTS: Clinically
      significant 'LogR neutral' genotyping abnormalities were detected in 0.5% of
      cases. Among these were a single case of chimerism, 12 cases with low level
      chromosome mosaicism, and 11 cases with an LCSH associated with uniparental
      disomy. In addition, the genotyping data revealed several LCSH associated with
      clinically relevant 'recessive type' genetic defects. CONCLUSIONS: These results 
      demonstrate the utility of SNP genotyping data for detection of clinically
      significant abnormalities, including chimerism/mosaicism and recessive Mendelian 
      disorders associated with autozygosity. The incidence of clinically significant
      low level mosaicism inferred from these cases suggests that this has hitherto
      been underestimated and chromosome mosaicism frequently occurs in the absence of 
      indicative clinical features. The growing appreciation among clinicians and
      demand for SNP genotyping data poses significant challenges for the
      interpretation of LCSH, especially where there is no detailed phenotypic
      description to direct laboratory analysis. Finally, reporting of unexpected or
      hidden consanguinity revealed by SNP array analysis raises potential ethical and 
      legal issues.
FAU - Bruno, D L
AU  - Bruno DL
AD  - Victorian Clinical Genetics Services, Murdoch Childrens Research Institute,
      Melbourne, Australia. damien.bruno@mcri.edu.au
FAU - White, S M
AU  - White SM
FAU - Ganesamoorthy, D
AU  - Ganesamoorthy D
FAU - Burgess, T
AU  - Burgess T
FAU - Butler, K
AU  - Butler K
FAU - Corrie, S
AU  - Corrie S
FAU - Francis, D
AU  - Francis D
FAU - Hills, L
AU  - Hills L
FAU - Prabhakara, K
AU  - Prabhakara K
FAU - Ngo, C
AU  - Ngo C
FAU - Norris, F
AU  - Norris F
FAU - Oertel, R
AU  - Oertel R
FAU - Pertile, M D
AU  - Pertile MD
FAU - Stark, Z
AU  - Stark Z
FAU - Amor, D J
AU  - Amor DJ
FAU - Slater, H R
AU  - Slater HR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111029
PL  - England
TA  - J Med Genet
JT  - Journal of medical genetics
JID - 2985087R
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Child
MH  - Child, Preschool
MH  - Chromosome Aberrations/*statistics & numerical data
MH  - Chromosome Mapping
MH  - Chromosomes, Human/genetics
MH  - DNA Copy Number Variations
MH  - Developmental Disabilities/genetics/pathology
MH  - Genetic Testing/methods
MH  - *Genotype
MH  - Humans
MH  - Infant
MH  - Intellectual Disability/genetics/pathology
MH  - Karyotyping/*methods
MH  - Loss of Heterozygosity
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Young Adult
EDAT- 2011/11/01 06:00
MHDA- 2012/03/09 06:00
CRDT- 2011/11/01 06:00
PHST- 2011/11/01 06:00 [entrez]
PHST- 2011/11/01 06:00 [pubmed]
PHST- 2012/03/09 06:00 [medline]
AID - jmedgenet-2011-100372 [pii]
AID - 10.1136/jmedgenet-2011-100372 [doi]
PST - ppublish
SO  - J Med Genet. 2011 Dec;48(12):831-9. doi: 10.1136/jmedgenet-2011-100372. Epub 2011
      Oct 29.


PMID- 22038764
OWN - NLM
STAT- MEDLINE
DCOM- 20120430
LR  - 20211020
IS  - 1552-4833 (Electronic)
IS  - 1552-4825 (Linking)
VI  - 155A
IP  - 12
DP  - 2011 Dec
TI  - Genomics really gets personal: how exome and whole genome sequencing challenge
      the ethical framework of human genetics research.
PG  - 2916-24
LID - 10.1002/ajmg.a.34357 [doi]
AB  - Exome sequencing (ES) and whole genome sequencing (WGS) putatively identify all
      adverse functional alleles of protein-coding genes. Accordingly, while ES/WGS are
      transformative new tools for gene discovery in human and medical genetics
      research, they also generate new manifestations of ethical issues related to the 
      consent process, data sharing, and return of results. These manifestations have
      yet to be comprehensively framed, due in part to the rapidity with which new
      technologies for ES/WGS are being applied and because of a lack of empirical data
      to provide guidance. Accordingly, researchers, funding agencies, and policy
      makers have largely dealt with these issues intuitively. We explain how use of
      ES/WGS challenges: (i) models under which informed consent is typically obtained;
      (ii) how harms associated with data sharing are considered; and (iii) the nature 
      of obligations surrounding unanticipated findings. We provide broad guidance
      about interim ways to contend with these issues and make broad recommendations
      for areas for novel resource and policy development.
CI  - Copyright (c) 2011 Wiley Periodicals, Inc.
FAU - Tabor, Holly K
AU  - Tabor HK
AD  - Department of Pediatrics, University of Washington, Seattle, Washington, USA.
      holly.tabor@seattlechildrens.org
FAU - Berkman, Benjamin E
AU  - Berkman BE
FAU - Hull, Sara Chandros
AU  - Hull SC
FAU - Bamshad, Michael J
AU  - Bamshad MJ
LA  - eng
GR  - R00 HG004316/HG/NHGRI NIH HHS/United States
GR  - 1UL1 RR025014/RR/NCRR NIH HHS/United States
GR  - 5R00HG004316-04/HG/NHGRI NIH HHS/United States
GR  - Z99 HG999999/Intramural NIH HHS/United States
GR  - R01 HG006618/HG/NHGRI NIH HHS/United States
GR  - UL1 RR025014/RR/NCRR NIH HHS/United States
GR  - 5P50HG003374-07/HG/NHGRI NIH HHS/United States
GR  - 1R01HG006618-01/HG/NHGRI NIH HHS/United States
GR  - P50 HG003374/HG/NHGRI NIH HHS/United States
PT  - Editorial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
DEP - 20111028
PL  - United States
TA  - Am J Med Genet A
JT  - American journal of medical genetics. Part A
JID - 101235741
SB  - IM
CIN - Am J Med Genet A. 2012 Oct;158A(10):2641-2; author reply 2643-4. PMID: 22903581
MH  - *Exome
MH  - Genetic Research/*ethics
MH  - *Genome, Human
MH  - Genomics/*ethics
MH  - Humans
MH  - Information Dissemination/ethics
MH  - Informed Consent
MH  - Sequence Analysis, DNA/*ethics
PMC - PMC4819320
MID - NIHMS771500
EDAT- 2011/11/01 06:00
MHDA- 2012/05/01 06:00
CRDT- 2011/11/01 06:00
PHST- 2011/05/03 00:00 [received]
PHST- 2011/09/25 00:00 [accepted]
PHST- 2011/11/01 06:00 [entrez]
PHST- 2011/11/01 06:00 [pubmed]
PHST- 2012/05/01 06:00 [medline]
AID - 10.1002/ajmg.a.34357 [doi]
PST - ppublish
SO  - Am J Med Genet A. 2011 Dec;155A(12):2916-24. doi: 10.1002/ajmg.a.34357. Epub 2011
      Oct 28.


PMID- 22038639
OWN - NLM
STAT- MEDLINE
DCOM- 20120706
LR  - 20211020
IS  - 2193-6226 (Electronic)
IS  - 2193-6218 (Linking)
VI  - 106
IP  - 2
DP  - 2011 Oct
TI  - [Ethical aspects in end-of-life care].
PG  - 137-48
LID - 10.1007/s00063-011-0057-y [doi]
AB  - Therapy decisions in the care of critically ill and dying patients in intensive
      care and emergency medicine must reflect probably conflicting issues of medical
      indications, ethics and law. This is of particular relevance when treatment
      preferences of patients are not known or are in contrast to those of the carers. 
      Difficulties regarding prognostication or with determining the beginning of an
      irreversible dying process may also lead to treatment situations that need
      ethical reflection. It is recommended to tackle medico-ethical issues by
      discussion of the meaning of relevant terms and medico-ethical principles,
      analyzing the professional self-image in intensive care and emergency medicine,
      consideration of options of palliative medicine and by use of an ethics case
      consultation.
FAU - Nauck, F
AU  - Nauck F
AD  - Abt. Palliativmedizin, Zentrum Anaesthesiologie, Rettungs- und Intensivmedizin,
      Georg-August-Universitat Gottingen, Deutschland.
      Friedemann.Nauck@med.uni-goettingen.de
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Ethische Aspekte in der Therapie am Lebensende.
DEP - 20111029
PL  - Germany
TA  - Med Klin Intensivmed Notfmed
JT  - Medizinische Klinik, Intensivmedizin und Notfallmedizin
JID - 101575086
SB  - IM
MH  - Critical Care/*ethics/legislation & jurisprudence
MH  - *Ethics, Medical
MH  - Euthanasia/ethics/legislation & jurisprudence
MH  - Germany
MH  - Humans
MH  - Legal Guardians/legislation & jurisprudence
MH  - Life Support Care/*ethics/legislation & jurisprudence
MH  - Medical Futility/ethics/legislation & jurisprudence
MH  - Palliative Care/*ethics/legislation & jurisprudence
MH  - Prognosis
EDAT- 2011/11/01 06:00
MHDA- 2012/07/07 06:00
CRDT- 2011/11/01 06:00
PHST- 2011/08/16 00:00 [received]
PHST- 2011/08/16 00:00 [accepted]
PHST- 2011/11/01 06:00 [entrez]
PHST- 2011/11/01 06:00 [pubmed]
PHST- 2012/07/07 06:00 [medline]
AID - 10.1007/s00063-011-0057-y [doi]
PST - ppublish
SO  - Med Klin Intensivmed Notfmed. 2011 Oct;106(2):137-48. doi:
      10.1007/s00063-011-0057-y. Epub 2011 Oct 29.


PMID- 22038559
OWN - NLM
STAT- MEDLINE
DCOM- 20130128
LR  - 20120723
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 8
DP  - 2012 Aug
TI  - Distress from voluntary refusal of food and fluids to hasten death: what is the
      role of continuous deep sedation?
PG  - 510-2
LID - 10.1136/medethics-2011-100278 [doi]
AB  - In assisted dying, the end-of-life trajectory is shortened to relieve unbearable 
      suffering. Unbearable suffering is defined broadly enough to include cognitive
      (early dementia), psychosocial or existential distress. It can include old-age
      afflictions that are neither life-threatening nor fatal in the "vulnerable
      elderly". The voluntary refusal of food and fluids (VRFF) combined with
      continuous deep sedation (CDS) for assisted dying is legal. Scientific
      understanding of awareness of internal and external nociceptive stimuli under CDS
      is rudimentary. CDS may blunt the wakefulness component of human consciousness
      without eradicating internal affective awareness of thirst and hunger. Patients
      may suffer because of the slow dying process following dehydration and
      starvation. The difficulty to adequately control distress, without bringing the
      dying process to a rapid conclusion by lethal pharmacological interventions, can 
      cause feelings of guilt among hospice and medical staff. Furthermore, the
      double-effect principle is not applicable in these situations because the primary
      objective of VRFF is to hasten death. Legal and societal debate should focus on
      sharpening the boundaries between assisted dying and palliative care. This
      separation is necessary to: 1) uphold trust in the patient-phyician relationship,
      and 2) preserve integrity and ethics of the medical profession.
FAU - Rady, Mohamed Y
AU  - Rady MY
FAU - Verheijde, Joseph L
AU  - Verheijde JL
LA  - eng
PT  - Journal Article
DEP - 20111029
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
RN  - 0 (Hypnotics and Sedatives)
SB  - IM
MH  - Aged
MH  - Aging
MH  - Arizona
MH  - Deep Sedation/*ethics/methods
MH  - Fluid Therapy
MH  - Food
MH  - Humans
MH  - Hypnotics and Sedatives/*administration & dosage
MH  - Patient Care Team
MH  - Physician-Patient Relations/ethics
MH  - Suicide, Assisted/*ethics
MH  - Terminal Care/*ethics
MH  - *Terminally Ill
MH  - Treatment Refusal/*ethics
EDAT- 2011/11/01 06:00
MHDA- 2013/01/29 06:00
CRDT- 2011/11/01 06:00
PHST- 2011/11/01 06:00 [entrez]
PHST- 2011/11/01 06:00 [pubmed]
PHST- 2013/01/29 06:00 [medline]
AID - medethics-2011-100278 [pii]
AID - 10.1136/medethics-2011-100278 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Aug;38(8):510-2. doi: 10.1136/medethics-2011-100278. Epub 2011
      Oct 29.


PMID- 22038063
OWN - NLM
STAT- MEDLINE
DCOM- 20131126
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 1
DP  - 2013 Mar
TI  - The ethical dilemma of embryonic stem cell research.
PG  - 97-106
LID - 10.1007/s11948-011-9326-7 [doi]
AB  - To determine the knowledge, attitude, and ethical concerns of medical students
      and graduates with regard to Embryonic Stem Cell (ESC) research. This
      questionnaire based descriptive study was conducted at the Civil Hospital Karachi
      (CHK), Pakistan from February to July 2008. A well structured questionnaire was
      administered to medical students and graduate doctors, which included their
      demographic profile as well as questions in line with the study objective.
      Informed consent was taken and full confidentiality was assured to the
      participants. Data were entered in a Statistical Package for Social Sciences
      (SPSS version.12) and analyzed. A total of 204 male and 216 female medical
      students and doctors were administered questionnaires out of which 105 males
      (51.4%) and 108 females (50%) were aware of the embryonic stem cell research and 
      its ethical implications. Forty percent males and 47% of females were of the
      opinion that life begins at conception. Forty-six percent males and 39% females
      were in favor of stem cell research while only 31% males and 28% females
      supported the ESC research. Less than 1/3 of students supported using frozen
      embryos for research purposes while more than 2/3 indicated that they were
      unlikely to support abortion for stem cell research purposes. The majority of the
      students were in favor of stem cell research with some reservations regarding ESC
      research. A sizeable number of students withheld their views, reflecting their
      poor understanding of medical ethics. The result of the study indicates a need
      for incorporating bioethics into the medical curriculum.
FAU - Manzar, Nabeel
AU  - Manzar N
AD  - Dow University of Health Sciences, Karachi, Pakistan. nmanzar2003@hotmail.com
FAU - Manzar, Bushra
AU  - Manzar B
FAU - Hussain, Nuzhat
AU  - Hussain N
FAU - Hussain, M Fawwad Ahmed
AU  - Hussain MF
FAU - Raza, Sajjad
AU  - Raza S
LA  - eng
PT  - Journal Article
DEP - 20111029
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Abortion, Induced/ethics
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - *Bioethical Issues
MH  - Biomedical Research/*ethics
MH  - Cryopreservation/ethics
MH  - Education, Medical, Graduate
MH  - Education, Medical, Undergraduate
MH  - *Embryonic Stem Cells
MH  - *Ethics, Research
MH  - Female
MH  - Health Services Needs and Demand
MH  - Hospitals
MH  - Humans
MH  - Male
MH  - Pakistan
MH  - Sex Factors
MH  - *Students, Medical
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2011/11/01 06:00
MHDA- 2013/12/16 06:00
CRDT- 2011/11/01 06:00
PHST- 2009/10/13 00:00 [received]
PHST- 2011/10/18 00:00 [accepted]
PHST- 2011/11/01 06:00 [entrez]
PHST- 2011/11/01 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1007/s11948-011-9326-7 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Mar;19(1):97-106. doi: 10.1007/s11948-011-9326-7. Epub 2011 
      Oct 29.


PMID- 22038062
OWN - NLM
STAT- MEDLINE
DCOM- 20131126
LR  - 20220330
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 1
DP  - 2013 Mar
TI  - Case-based knowledge and ethics education: improving learning and transfer
      through emotionally rich cases.
PG  - 265-86
LID - 10.1007/s11948-011-9318-7 [doi]
AB  - Case-based instruction is a stable feature of ethics education, however, little
      is known about the attributes of the cases that make them effective. Emotions are
      an inherent part of ethical decision-making and one source of information
      actively stored in case-based knowledge, making them an attribute of cases that
      likely facilitates case-based learning. Emotions also make cases more realistic, 
      an essential component for effective case-based instruction. The purpose of this 
      study was to investigate the influence of emotional case content, and
      complementary socio-relational case content, on case-based knowledge acquisition 
      and transfer on future ethical decision-making tasks. Study findings suggest that
      emotional case content stimulates retention of cases and facilitates transfer of 
      ethical decision-making principles demonstrated in cases.
FAU - Thiel, Chase E
AU  - Thiel CE
AD  - Psychology Department, University of Oklahoma, Norman, OK 73019-2007, USA.
      cthiel@ou.edu
FAU - Connelly, Shane
AU  - Connelly S
FAU - Harkrider, Lauren
AU  - Harkrider L
FAU - Devenport, Lynn D
AU  - Devenport LD
FAU - Bagdasarov, Zhanna
AU  - Bagdasarov Z
FAU - Johnson, James F
AU  - Johnson JF
FAU - Mumford, Michael D
AU  - Mumford MD
LA  - eng
PT  - Journal Article
DEP - 20111027
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Adult
MH  - Decision Making/*ethics
MH  - *Emotions
MH  - Female
MH  - Humans
MH  - Knowledge Bases
MH  - *Learning
MH  - Male
MH  - *Moral Development
MH  - Social Environment
MH  - Teaching/*methods
EDAT- 2011/11/01 06:00
MHDA- 2013/12/16 06:00
CRDT- 2011/11/01 06:00
PHST- 2011/04/29 00:00 [received]
PHST- 2011/10/14 00:00 [accepted]
PHST- 2011/11/01 06:00 [entrez]
PHST- 2011/11/01 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1007/s11948-011-9318-7 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Mar;19(1):265-86. doi: 10.1007/s11948-011-9318-7. Epub 2011 
      Oct 27.


PMID- 22037984
OWN - NLM
STAT- MEDLINE
DCOM- 20120612
LR  - 20111118
IS  - 1496-8975 (Electronic)
IS  - 0832-610X (Linking)
VI  - 58
IP  - 12
DP  - 2011 Dec
TI  - Guidelines on the ethics of clinical research in anesthesia.
PG  - 1115-24
LID - 10.1007/s12630-011-9596-1 [doi]
FAU - Hall, Richard
AU  - Hall R
AD  - Dalhousie University, Halifax, NS, Canada. rihall@dal.ca
FAU - McKnight, David
AU  - McKnight D
FAU - Cox, Robin
AU  - Cox R
FAU - Coonan, Tom
AU  - Coonan T
CN  - Canadian Anesthesiologists' Society
LA  - eng
LA  - fre
PT  - Guideline
PT  - Journal Article
DEP - 20111029
PL  - United States
TA  - Can J Anaesth
JT  - Canadian journal of anaesthesia = Journal canadien d'anesthesie
JID - 8701709
SB  - IM
MH  - Anesthesia/*methods
MH  - Anesthesiology/ethics
MH  - Biomedical Research/*ethics
MH  - Canada
MH  - *Ethics, Research
MH  - Humans
EDAT- 2011/11/01 06:00
MHDA- 2012/06/13 06:00
CRDT- 2011/11/01 06:00
PHST- 2011/08/23 00:00 [received]
PHST- 2011/09/14 00:00 [accepted]
PHST- 2011/11/01 06:00 [entrez]
PHST- 2011/11/01 06:00 [pubmed]
PHST- 2012/06/13 06:00 [medline]
AID - 10.1007/s12630-011-9596-1 [doi]
PST - ppublish
SO  - Can J Anaesth. 2011 Dec;58(12):1115-24. doi: 10.1007/s12630-011-9596-1. Epub 2011
      Oct 29.


PMID- 22037899
OWN - NLM
STAT- MEDLINE
DCOM- 20121030
LR  - 20211020
IS  - 1573-3599 (Electronic)
IS  - 1059-7700 (Linking)
VI  - 21
IP  - 4
DP  - 2012 Aug
TI  - Information related to prenatal genetic counseling: interpretation by
      adolescents, effects on risk perception and ethical implications.
PG  - 536-46
LID - 10.1007/s10897-011-9418-1 [doi]
AB  - Being raised in the genomic era may not only increase knowledge of available
      genetic testing but may also have an impact on how genetic information is
      perceived. However, little is known about how current adolescents react to the
      language commonly used by health care professionals providing prenatal
      counseling. In addition, as risk communication is related to numbers and figures,
      having different educational backgrounds may be associated with variability in
      risk perceptions. In order to investigate these issues, a previously developed
      questionnaire studying different ways of being told about hypothetical anomalies 
      in a baby and corresponding risks (Abramsky and Fletcher Prenatal Diagnosis
      22(13):1188-1194, 2002) was administered to high-school students in Sweden. A
      total of 344 questionnaires were completed by students belonging to a natural
      science or a social science program. The data show that teenage participants
      found technical jargon and words such as rare and abnormal more worrying than the
      presented comparison terms. Negative framing effects and perception differences
      related to numeric risk formats were also present. Additionally, participants'
      gender and educational program did not seem to have an effect on risk assessment.
      In addition to reporting the questionnaire results, we discuss the ethical
      implications of the data based on the norm of non-directiveness and make some
      recommendations for practice. In general, genetic counselors should be aware that
      the language used within clinical services can be influential on this group of
      upcoming counselees.
FAU - Melas, Philippe A
AU  - Melas PA
AD  - Department of Molecular Medicine and Surgery, Neurogenetics Unit, Karolinska
      Institutet, Stockholm, Sweden. philippe.melas@ki.se
FAU - Georgsson Ohman, Susanne
AU  - Georgsson Ohman S
FAU - Juth, Niklas
AU  - Juth N
FAU - Bui, The-Hung
AU  - Bui TH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111025
PL  - United States
TA  - J Genet Couns
JT  - Journal of genetic counseling
JID - 9206865
SB  - IM
MH  - Adolescent
MH  - *Ethics
MH  - Female
MH  - *Genetic Counseling
MH  - Humans
MH  - Male
MH  - *Risk
MH  - Surveys and Questionnaires
EDAT- 2011/11/01 06:00
MHDA- 2012/10/31 06:00
CRDT- 2011/11/01 06:00
PHST- 2011/03/01 00:00 [received]
PHST- 2011/10/06 00:00 [accepted]
PHST- 2011/11/01 06:00 [entrez]
PHST- 2011/11/01 06:00 [pubmed]
PHST- 2012/10/31 06:00 [medline]
AID - 10.1007/s10897-011-9418-1 [doi]
PST - ppublish
SO  - J Genet Couns. 2012 Aug;21(4):536-46. doi: 10.1007/s10897-011-9418-1. Epub 2011
      Oct 25.


PMID- 22037898
OWN - NLM
STAT- MEDLINE
DCOM- 20120613
LR  - 20211020
IS  - 1573-3599 (Electronic)
IS  - 1059-7700 (Linking)
VI  - 21
IP  - 1
DP  - 2012 Feb
TI  - Commentary: how individual and profession-level factors influence discussion of
      disability in prenatal genetic counseling.
PG  - 24-6
LID - 10.1007/s10897-011-9416-3 [doi]
AB  - Hodgson and Weil (Journal of Genetic Counseling, 2011) reports on two interactive
      workshops in which genetic counselors identified a broad set of counseling issues
      that may be impediments to promoting an adequate discussion of disability in
      prenatal genetic counseling. The present commentary discusses two factors that we
      infer underlie these counseling issues. First, countertransference concerning
      disability, which is normal and expected, may influence genetic counselors'
      decisions about raising and exploring the complex topic of disability in prenatal
      genetic counseling. Second, the limited involvement of the profession of genetic 
      counseling in the complex social and ethical issues of disability provide little 
      guidance to the individual genetic counselor with respect to discussing
      disability in prenatal diagnosis counseling. We suggest both factors must be
      acknowledged and addressed in order to adequately implement the recommendations
      presented in Hodgson and Weil (Journal of Genetic Counseling, 2011) as well as
      other efforts to increase discussion of disability in prenatal diagnosis
      counseling in the service of informed decision making.
FAU - Hodgson, Jan
AU  - Hodgson J
FAU - Weil, Jon
AU  - Weil J
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20111025
PL  - United States
TA  - J Genet Couns
JT  - Journal of genetic counseling
JID - 9206865
SB  - IM
CON - J Genet Couns. 1992 Sep;1(3):227-43. PMID: 11654110
CON - J Genet Couns. 2008 Jun;17(3):220-33. PMID: 17701451
MH  - *Eugenics
MH  - Female
MH  - *Genetic Counseling
MH  - Humans
MH  - Male
MH  - *Peer Group
EDAT- 2011/11/01 06:00
MHDA- 2012/06/14 06:00
CRDT- 2011/11/01 06:00
PHST- 2011/09/21 00:00 [received]
PHST- 2011/09/21 00:00 [accepted]
PHST- 2011/11/01 06:00 [entrez]
PHST- 2011/11/01 06:00 [pubmed]
PHST- 2012/06/14 06:00 [medline]
AID - 10.1007/s10897-011-9416-3 [doi]
PST - ppublish
SO  - J Genet Couns. 2012 Feb;21(1):24-6. doi: 10.1007/s10897-011-9416-3. Epub 2011 Oct
      25.


PMID- 22037887
OWN - NLM
STAT- MEDLINE
DCOM- 20120820
LR  - 20211020
IS  - 1527-974X (Electronic)
IS  - 1067-5027 (Linking)
VI  - 19
IP  - 3
DP  - 2012 May-Jun
TI  - The future of health IT innovation and informatics: a report from AMIA's 2010
      policy meeting.
PG  - 460-7
LID - 10.1136/amiajnl-2011-000522 [doi]
AB  - While much attention has been paid to the short-term impact that widespread
      adoption of health information technology (health IT) will have on the healthcare
      system, there is a corresponding need to look at the long-term effects that
      extant policies may have on health IT system resilience, innovation, and related 
      ethical, social/legal issues. The American Medical Informatics Association's 2010
      Health Policy Conference was convened to further the national discourse on the
      issues surrounding these longer-term considerations. Conference participants
      self-selected into three broad categories: resilience in healthcare and health
      IT; ethical, legal, and social challenges; and innovation, adoption, and
      sustainability. The discussions about problem areas lead to findings focusing on 
      the lack of encouragement for long-term IT innovation that may result from
      current health IT policies; the potential impact of uneven adoption of health IT 
      based on the exclusions of the current financial incentives; the weaknesses of
      contingency and risk mitigation planning that threaten system resilience; and
      evolving standards developed in response to challenges relating to the security, 
      integrity, and availability of electronic health information. This paper
      discusses these findings and also offers recommendations that address the
      interwoven topics of innovation, resilience, and adoption. The goal of this paper
      is to encourage public and private sector organizations that have a role in
      shaping health information policy to increase attention to developing a national 
      strategy that assures that health IT innovation and resilience are not impeded by
      shorter-term efforts to implement current approaches emphasizing adoption and
      meaningful use of electronic health records.
FAU - McGowan, Julie J
AU  - McGowan JJ
AD  - Knowledge Informatics and Translation, Indiana University School of Medicine,
      Indianapolis, Indiana, USA.
FAU - Cusack, Caitlin M
AU  - Cusack CM
FAU - Bloomrosen, Meryl
AU  - Bloomrosen M
LA  - eng
PT  - Congress
PT  - Research Support, Non-U.S. Gov't
DEP - 20111028
PL  - England
TA  - J Am Med Inform Assoc
JT  - Journal of the American Medical Informatics Association : JAMIA
JID - 9430800
SB  - IM
MH  - *Diffusion of Innovation
MH  - Health Plan Implementation/*organization & administration
MH  - *Health Policy
MH  - Humans
MH  - Medical Informatics/*organization & administration
MH  - Organizational Innovation
MH  - Societies, Scientific
MH  - United States
PMC - PMC3341794
EDAT- 2011/11/01 06:00
MHDA- 2012/08/21 06:00
CRDT- 2011/11/01 06:00
PHST- 2011/11/01 06:00 [entrez]
PHST- 2011/11/01 06:00 [pubmed]
PHST- 2012/08/21 06:00 [medline]
AID - amiajnl-2011-000522 [pii]
AID - 10.1136/amiajnl-2011-000522 [doi]
PST - ppublish
SO  - J Am Med Inform Assoc. 2012 May-Jun;19(3):460-7. doi:
      10.1136/amiajnl-2011-000522. Epub 2011 Oct 28.


PMID- 22037796
OWN - NLM
STAT- MEDLINE
DCOM- 20120118
LR  - 20211020
IS  - 1573-7284 (Electronic)
IS  - 0393-2990 (Linking)
VI  - 26
IP  - 10
DP  - 2011 Oct
TI  - STrengthening the reporting of OBservational studies in Epidemiology-Molecular
      Epidemiology (STROBE-ME): an extension of the STROBE statement.
PG  - 797-810
LID - 10.1007/s10654-011-9622-1 [doi]
AB  - Advances in laboratory techniques have led to a rapidly increasing use of
      biomarkers in epidemiological studies. Biomarkers of internal dose, early
      biological change, susceptibility, and clinical outcomes are used as proxies for 
      investigating the interactions between external and/or endogenous agents and the 
      body components or processes. The need for improved reporting of scientific
      research led to influential statements of recommendations such as STrengthening
      Reporting of Observational studies in Epidemiology (STROBE) statement. The STROBE
      initiative established in 2004 aimed to provide guidance on how to report
      observational research. Its guidelines provide a user-friendly checklist of 22
      items to be reported in epidemiological studies, with items specific to the three
      main study designs: cohort studies, case-control studies and cross-sectional
      studies. The present STrengthening the Reporting of OBservational studies in
      Epidemiology-Molecular Epidemiology (STROBE-ME) initiative builds on the STROBE
      Statement implementing 9 existing items of STROBE and providing 17 additional
      items to the 22 items of STROBE checklist. The additions relate to the use of
      biomarkers in epidemiological studies, concerning collection, handling and
      storage of biological samples; laboratory methods, validity and reliability of
      biomarkers; specificities of study design; and ethical considerations. The
      STROBE-ME recommendations are intended to complement the STROBE recommendations.
FAU - Gallo, Valentina
AU  - Gallo V
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Imperial
      College London, St Mary's Campus Norfolk Place, W2 1PG London, UK.
      v.gallo@imperial.ac.uk
FAU - Egger, Matthias
AU  - Egger M
FAU - McCormack, Valerie
AU  - McCormack V
FAU - Farmer, Peter B
AU  - Farmer PB
FAU - Ioannidis, John P A
AU  - Ioannidis JP
FAU - Kirsch-Volders, Micheline
AU  - Kirsch-Volders M
FAU - Matullo, Giuseppe
AU  - Matullo G
FAU - Phillips, David H
AU  - Phillips DH
FAU - Schoket, Bernadette
AU  - Schoket B
FAU - Stromberg, Ulf
AU  - Stromberg U
FAU - Vermeulen, Roel
AU  - Vermeulen R
FAU - Wild, Christopher
AU  - Wild C
FAU - Porta, Miquel
AU  - Porta M
FAU - Vineis, Paolo
AU  - Vineis P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111029
PL  - Netherlands
TA  - Eur J Epidemiol
JT  - European journal of epidemiology
JID - 8508062
RN  - 0 (Biomarkers)
SB  - IM
CIN - Eur J Epidemiol. 2011 Oct;26(10):761-2. PMID: 22076058
EIN - Eur J Epidemiol. 2012 Feb;27(2):151
MH  - *Biomarkers
MH  - Case-Control Studies
MH  - Checklist
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - *Epidemiologic Research Design
MH  - *Epidemiologic Studies
MH  - *Guidelines as Topic
MH  - Humans
MH  - *Molecular Epidemiology
MH  - Observation/methods
MH  - Reference Standards
MH  - Reproducibility of Results
EDAT- 2011/11/01 06:00
MHDA- 2012/01/19 06:00
CRDT- 2011/11/01 06:00
PHST- 2010/11/02 00:00 [received]
PHST- 2011/09/30 00:00 [accepted]
PHST- 2011/11/01 06:00 [entrez]
PHST- 2011/11/01 06:00 [pubmed]
PHST- 2012/01/19 06:00 [medline]
AID - 10.1007/s10654-011-9622-1 [doi]
PST - ppublish
SO  - Eur J Epidemiol. 2011 Oct;26(10):797-810. doi: 10.1007/s10654-011-9622-1. Epub
      2011 Oct 29.


PMID- 22037229
OWN - NLM
STAT- MEDLINE
DCOM- 20120424
LR  - 20131121
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 506
IP  - 1
DP  - 2012 Jan 6
TI  - Permanent expression of midbrain dopaminergic neurons traits in differentiated
      amniotic epithelial cells.
PG  - 22-7
LID - 10.1016/j.neulet.2011.10.038 [doi]
AB  - Amniotic epithelial cells (AECs) have been the subject of interest due to their
      stem cells characteristics. Pluripotency, lack of teratoma formation, low
      immunogenicity and no ethical issues make them an alternative source of stem
      cells for generation of dopaminergic neurons in vitro. AECs may differentiate
      into midbrain dopaminergic neurons in the presence of induction factors which
      trigger pathway naturally occurring in the mesencephalon during embryogenesis. In
      this study, we examined whether FGF8 and Sonic hedgehog (Shh) can induce AECs to 
      express permanently midbrain dopaminergic neurons traits. We found that fresh
      isolated AECs temporarily expressed some neural markers which decreased 7 days
      after culture. Co-treatment of cells with FGF8 and Shh had synergistic effect on 
      expression of TH, DAT, Pax2, Lmx1b and En1. Shh ceased differentiation in
      dopaminergic state and decreased DbetaH. HPLC analysis revealed that dopamine was
      released into the medium upon depolarization, indicating that functional
      dopaminergic neurons were present in the culture. These results demonstrate that 
      AECs have capability to differentiate into dopaminergic neurons and can be a
      candidate for cell replacement therapy of Parkinson's disease.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Niknejad, Hassan
AU  - Niknejad H
AD  - Nanomedicine and Tissue Engineering Research Center, Shahid Beheshti University
      of Medical Sciences, Tehran, Iran. niknejad@sbmu.ac.ir
FAU - Deihim, Tina
AU  - Deihim T
FAU - Ahmadiani, Abolhassan
AU  - Ahmadiani A
FAU - Jorjani, Masoumeh
AU  - Jorjani M
FAU - Peirovi, Habibollah
AU  - Peirovi H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111021
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Dopamine Plasma Membrane Transport Proteins)
RN  - 0 (FGF8 protein, human)
RN  - 0 (Hedgehog Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Transcription Factors)
RN  - 148997-75-5 (Fibroblast Growth Factor 8)
RN  - EC 1.14.16.2 (Tyrosine 3-Monooxygenase)
RN  - EC 1.14.17.1 (Dopamine beta-Hydroxylase)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Analysis of Variance
MH  - Cell Differentiation/drug effects/*physiology
MH  - Cells, Cultured
MH  - Chromatography, High Pressure Liquid
MH  - Dopamine/*metabolism
MH  - Dopamine Plasma Membrane Transport Proteins/metabolism
MH  - Dopamine beta-Hydroxylase/metabolism
MH  - Dopaminergic Neurons/*metabolism
MH  - Epithelial Cells/drug effects/*physiology
MH  - Female
MH  - Fibroblast Growth Factor 8/pharmacology
MH  - Hedgehog Proteins/pharmacology
MH  - Humans
MH  - Nerve Tissue Proteins/metabolism
MH  - Placenta/*cytology
MH  - Pregnancy
MH  - Transcription Factors/metabolism
MH  - Tyrosine 3-Monooxygenase/metabolism
EDAT- 2011/11/01 06:00
MHDA- 2012/04/25 06:00
CRDT- 2011/11/01 06:00
PHST- 2011/08/04 00:00 [received]
PHST- 2011/09/27 00:00 [revised]
PHST- 2011/10/14 00:00 [accepted]
PHST- 2011/11/01 06:00 [entrez]
PHST- 2011/11/01 06:00 [pubmed]
PHST- 2012/04/25 06:00 [medline]
AID - S0304-3940(11)01436-4 [pii]
AID - 10.1016/j.neulet.2011.10.038 [doi]
PST - ppublish
SO  - Neurosci Lett. 2012 Jan 6;506(1):22-7. doi: 10.1016/j.neulet.2011.10.038. Epub
      2011 Oct 21.


PMID- 22037126
OWN - NLM
STAT- MEDLINE
DCOM- 20121218
LR  - 20220409
IS  - 1876-4754 (Electronic)
IS  - 1876-4754 (Linking)
VI  - 5
IP  - 3
DP  - 2012 Jul
TI  - Clinical research with transcranial direct current stimulation (tDCS): challenges
      and future directions.
PG  - 175-195
LID - S1935-861X(11)00026-X [pii]
LID - 10.1016/j.brs.2011.03.002 [doi]
AB  - BACKGROUND: Transcranial direct current stimulation (tDCS) is a neuromodulatory
      technique that delivers low-intensity, direct current to cortical areas
      facilitating or inhibiting spontaneous neuronal activity. In the past 10 years,
      tDCS physiologic mechanisms of action have been intensively investigated giving
      support for the investigation of its applications in clinical neuropsychiatry and
      rehabilitation. However, new methodologic, ethical, and regulatory issues emerge 
      when translating the findings of preclinical and phase I studies into phase II
      and III clinical studies. The aim of this comprehensive review is to discuss the 
      key challenges of this process and possible methods to address them. METHODS: We 
      convened a workgroup of researchers in the field to review, discuss, and provide 
      updates and key challenges of tDCS use in clinical research. MAIN
      FINDINGS/DISCUSSION: We reviewed several basic and clinical studies in the field 
      and identified potential limitations, taking into account the particularities of 
      the technique. We review and discuss the findings into four topics: (1)
      mechanisms of action of tDCS, parameters of use and computer-based human brain
      modeling investigating electric current fields and magnitude induced by tDCS; (2)
      methodologic aspects related to the clinical research of tDCS as divided
      according to study phase (ie, preclinical, phase I, phase II, and phase III
      studies); (3) ethical and regulatory concerns; and (4) future directions
      regarding novel approaches, novel devices, and future studies involving tDCS.
      Finally, we propose some alternative methods to facilitate clinical research on
      tDCS.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Brunoni, Andre Russowsky
AU  - Brunoni AR
AD  - Department of Neurosciences and Behavior, Institute of Psychology, University of 
      Sao Paulo, Sao Paulo, Brazil.
FAU - Nitsche, Michael A
AU  - Nitsche MA
AD  - Department of Clinical Neurophysiology, Georg-August University, Goettingen,
      Germany.
FAU - Bolognini, Nadia
AU  - Bolognini N
AD  - Department of Psychology, University of Milano-Bicocca, Milan, Italy;
      Neuropsychological Laboratory, IRCCS Instituto Auxologico Italiano, Milan, Italy.
FAU - Bikson, Marom
AU  - Bikson M
AD  - The City College of City University of New York, New York, New York.
FAU - Wagner, Tim
AU  - Wagner T
AD  - Massachusetts Institute of Technology, Boston, Massachusetts.
FAU - Merabet, Lotfi
AU  - Merabet L
AD  - Massachusets Eye and Ear Infirmary, Harvard University, Boston, Massachusetts.
FAU - Edwards, Dylan J
AU  - Edwards DJ
AD  - Burke Medical Research Institute, White Plains, New York.
FAU - Valero-Cabre, Antoni
AU  - Valero-Cabre A
AD  - Boston University School of Medicine, Boston, Massachusetts.
FAU - Rotenberg, Alexander
AU  - Rotenberg A
AD  - Department of Neurology, Children's Hospital, Harvard Medical School, Boston,
      Massachusetts.
FAU - Pascual-Leone, Alvaro
AU  - Pascual-Leone A
AD  - Berenson-Allen Center for Non-invasive Brain Stimulation, Beth Israel Deaconess
      Medical Center, Harvard Medical School, Boston, Massachusetts.
FAU - Ferrucci, Roberta
AU  - Ferrucci R
AD  - Centro Clinico per la Neurostimolazione, le Neurotecnologie ed i Disordini del
      Movimento, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Universita 
      degli Studi di Milano Dipartimento di Scienze Neurologiche, Milan, Italy.
FAU - Priori, Alberto
AU  - Priori A
AD  - Centro Clinico per la Neurostimolazione, le Neurotecnologie ed i Disordini del
      Movimento, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Universita 
      degli Studi di Milano Dipartimento di Scienze Neurologiche, Milan, Italy.
FAU - Boggio, Paulo Sergio
AU  - Boggio PS
AD  - Social and Cognitive Neuroscience Laboratory and Developmental Disorders Program,
      Center for Health and Biological Sciences, Mackenzie Prebyterian University, Sao 
      Paulo, Brazil.
FAU - Fregni, Felipe
AU  - Fregni F
AD  - Laboratory of Neuromodulation, Department of Physical Medicine and
      Rehabilitation, Spaulding Rehabilitation Hospital and Massachusetts General
      Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:
      fregni.felipe@mgh.harvard.edu.
LA  - eng
GR  - R21 HD060999-01/HD/NICHD NIH HHS/United States
GR  - 5R21DK081773-03/DK/NIDDK NIH HHS/United States
GR  - R21 DK081773/DK/NIDDK NIH HHS/United States
GR  - R01 HD069776/HD/NICHD NIH HHS/United States
GR  - R21 DK081773-03/DK/NIDDK NIH HHS/United States
GR  - R21HD060999/HD/NICHD NIH HHS/United States
GR  - R21 HD060999/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20110401
PL  - United States
TA  - Brain Stimul
JT  - Brain stimulation
JID - 101465726
SB  - IM
MH  - Animals
MH  - Biomedical Research/*trends
MH  - Brain/*physiopathology
MH  - Brain Diseases/*physiopathology/*therapy
MH  - *Forecasting
MH  - Humans
MH  - Transcranial Magnetic Stimulation/*trends
PMC - PMC3270156
MID - NIHMS283820
EDAT- 2011/11/01 06:00
MHDA- 2012/12/19 06:00
CRDT- 2011/11/01 06:00
PHST- 2010/11/07 00:00 [received]
PHST- 2011/01/25 00:00 [revised]
PHST- 2011/03/03 00:00 [accepted]
PHST- 2011/11/01 06:00 [entrez]
PHST- 2011/11/01 06:00 [pubmed]
PHST- 2012/12/19 06:00 [medline]
AID - S1935-861X(11)00026-X [pii]
AID - 10.1016/j.brs.2011.03.002 [doi]
PST - ppublish
SO  - Brain Stimul. 2012 Jul;5(3):175-195. doi: 10.1016/j.brs.2011.03.002. Epub 2011
      Apr 1.


PMID- 22037085
OWN - NLM
STAT- MEDLINE
DCOM- 20120228
LR  - 20220409
IS  - 1119-3077 (Print)
VI  - 14
IP  - 3
DP  - 2011 Jul-Sep
TI  - Prognosis and outcome of acute stroke in the University College Hospital Ibadan, 
      Nigeria.
PG  - 359-62
LID - 10.4103/1119-3077.86784 [doi]
AB  - BACKGROUND: Many factors influence the outcome of acute stroke, the third leading
      cause of morbidity and mortality globally. OBJECTIVE: To identify the
      determinants of outcome of acute stroke. MATERIALS AND METHODS: A prospectively
      study of 66 adult patients who presented to the medical emergency unit of
      University College Hospital (U.C.H), Ibadan, in coma from acute stroke, from
      August 2004 to March 2005, was undertaken after obtaining ethical clearance and
      written consent of the patients' relations. RESULT: Acute stroke constituted 33% 
      of medical coma, 3.2% of hospital emergencies, 1.0% of total hospital admissions,
      and 7.3% of medical deaths during the study period. The stroke subtypes were
      intracerebral hemorrhage (78.8%) and large cerebral infarction (21.2%) with
      respective case fatalities of 69.7% and 13.6% at 4 weeks. Males constituted 75.8%
      of the patient population with sex-specific mortality of 68.2%. The highest age
      specific mortality of 65.2% was in the 40-59 years group. The common risk factors
      were systemic hypertension, obesity, alcohol/substance abuse, and diabetes
      mellitus. Co-morbidities included aspiration pneumonia, recurrent seizures,
      hyperglycemia, and sepsis. CONCLUSION: Age above 39 years, male gender, systemic 
      hypertension, early onset of coma after stroke, and presence of co-morbidities
      were associated with poor stroke outcome.
FAU - Obiako, O R
AU  - Obiako OR
AD  - Department of Medicine, Ahmadu Bello University Teaching Hospital, Zaria,
      Nigeria.
FAU - Oparah, S K
AU  - Oparah SK
FAU - Ogunniyi, A
AU  - Ogunniyi A
LA  - eng
PT  - Journal Article
PL  - India
TA  - Niger J Clin Pract
JT  - Nigerian journal of clinical practice
JID - 101150032
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Age Distribution
MH  - Aged
MH  - Cerebral Hemorrhage/complications/*mortality
MH  - Cerebral Infarction/complications/*mortality
MH  - Coma/*etiology/mortality
MH  - Female
MH  - Hospitalization/statistics & numerical data
MH  - Hospitals, University
MH  - Humans
MH  - Hypertension/complications/*mortality
MH  - Male
MH  - Middle Aged
MH  - Nigeria/epidemiology
MH  - Prognosis
MH  - Prospective Studies
MH  - Risk Factors
MH  - Socioeconomic Factors
MH  - Stroke/complications/*mortality
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2011/11/01 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/11/01 06:00
PHST- 2011/11/01 06:00 [entrez]
PHST- 2011/11/01 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - NigerJClinPract_2011_14_3_359_86784 [pii]
AID - 10.4103/1119-3077.86784 [doi]
PST - ppublish
SO  - Niger J Clin Pract. 2011 Jul-Sep;14(3):359-62. doi: 10.4103/1119-3077.86784.


PMID- 22037056
OWN - NLM
STAT- MEDLINE
DCOM- 20120523
LR  - 20220317
IS  - 1758-1117 (Electronic)
IS  - 0023-6772 (Linking)
VI  - 46
IP  - 1
DP  - 2012 Jan
TI  - A step-by-step guide to systematically identify all relevant animal studies.
PG  - 24-31
LID - 10.1258/la.2011.011087 [doi]
AB  - Before starting a new animal experiment, thorough analysis of previously
      performed experiments is essential from a scientific as well as from an ethical
      point of view. The method that is most suitable to carry out such a thorough
      analysis of the literature is a systematic review (SR). An essential first step
      in an SR is to search and find all potentially relevant studies. It is important 
      to include all available evidence in an SR to minimize bias and reduce hampered
      interpretation of experimental outcomes. Despite the recent development of search
      filters to find animal studies in PubMed and EMBASE, searching for all available 
      animal studies remains a challenge. Available guidelines from the clinical field 
      cannot be copied directly to the situation within animal research, and although
      there are plenty of books and courses on searching the literature, there is no
      compact guide available to search and find relevant animal studies. Therefore, in
      order to facilitate a structured, thorough and transparent search for animal
      studies (in both preclinical and fundamental science), an easy-to-use,
      step-by-step guide was prepared and optimized using feedback from scientists in
      the field of animal experimentation. The step-by-step guide will assist
      scientists in performing a comprehensive literature search and, consequently,
      improve the scientific quality of the resulting review and prevent unnecessary
      animal use in the future.
FAU - Leenaars, Marlies
AU  - Leenaars M
AD  - 3R Research Centre, Central Animal Laboratory, Radboud University Nijmegen
      Medical Centre, 6500 HB Nijmegen, The Netherlands. M.Leenaars@cdl.umcn.nl
FAU - Hooijmans, Carlijn R
AU  - Hooijmans CR
FAU - van Veggel, Nieky
AU  - van Veggel N
FAU - ter Riet, Gerben
AU  - ter Riet G
FAU - Leeflang, Mariska
AU  - Leeflang M
FAU - Hooft, Lotty
AU  - Hooft L
FAU - van der Wilt, Gert Jan
AU  - van der Wilt GJ
FAU - Tillema, Alice
AU  - Tillema A
FAU - Ritskes-Hoitinga, Merel
AU  - Ritskes-Hoitinga M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20111028
PL  - England
TA  - Lab Anim
JT  - Laboratory animals
JID - 0112725
SB  - IM
MH  - *Animal Experimentation
MH  - Animals
MH  - Animals, Laboratory
MH  - Biomedical Research/*methods
MH  - *Databases, Bibliographic
MH  - Information Storage and Retrieval
MH  - Research Design/standards
MH  - Review Literature as Topic
MH  - Search Engine
PMC - PMC3265183
EDAT- 2011/11/01 06:00
MHDA- 2012/05/24 06:00
CRDT- 2011/11/01 06:00
PHST- 2011/11/01 06:00 [entrez]
PHST- 2011/11/01 06:00 [pubmed]
PHST- 2012/05/24 06:00 [medline]
AID - la.2011.011087 [pii]
AID - 10.1258/la.2011.011087 [doi]
PST - ppublish
SO  - Lab Anim. 2012 Jan;46(1):24-31. doi: 10.1258/la.2011.011087. Epub 2011 Oct 28.


PMID- 22036484
OWN - NLM
STAT- MEDLINE
DCOM- 20120315
LR  - 20111031
IS  - 1558-0776 (Electronic)
IS  - 1071-9091 (Linking)
VI  - 18
IP  - 2
DP  - 2011 Jun
TI  - A brief synopsis of the "why, what, and how" of teaching ethics to pediatric
      neurology trainees.
PG  - 79-80
LID - 10.1016/j.spen.2011.05.009 [doi]
FAU - Shevell, Michael I
AU  - Shevell MI
AD  - Department of Neurology/Neurosurgery and Pediatrics, McGill University and
      Division of Pediatric Neurology, Montreal Children's Hospital-McGill, University 
      Health Center, Montreal, Quebec, Canada. michael.shevell@muhc.mcgill.ca
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Semin Pediatr Neurol
JT  - Seminars in pediatric neurology
JID - 9441351
SB  - IM
MH  - Child
MH  - Education, Medical, Graduate/*methods
MH  - Ethics, Medical/*education
MH  - Humans
MH  - Neurology/*education
EDAT- 2011/11/01 06:00
MHDA- 2012/03/16 06:00
CRDT- 2011/11/01 06:00
PHST- 2011/11/01 06:00 [entrez]
PHST- 2011/11/01 06:00 [pubmed]
PHST- 2012/03/16 06:00 [medline]
AID - S1071-9091(11)00039-8 [pii]
AID - 10.1016/j.spen.2011.05.009 [doi]
PST - ppublish
SO  - Semin Pediatr Neurol. 2011 Jun;18(2):79-80. doi: 10.1016/j.spen.2011.05.009.


PMID- 22036270
OWN - NLM
STAT- MEDLINE
DCOM- 20120514
LR  - 20191210
IS  - 1532-2793 (Electronic)
IS  - 0260-6917 (Linking)
VI  - 32
IP  - 2
DP  - 2012 Feb
TI  - Involving people with learning disabilities in nurse education: towards an
      inclusive approach.
PG  - 173-7
LID - 10.1016/j.nedt.2011.10.002 [doi]
AB  - There is limited evidence that explores how to effectively include people with
      learning disabilities in nurse education in the U.K. The majority of reported
      work relates to mental health nursing and social work training (Morgan and Jones,
      2009). This paper specifically reports on the processes and activities undertaken
      by the authors with people with learning disabilities in the development of a new
      BSc learning disability nursing programme, a specific branch of nursing in the
      U.K. In doing so, findings and discussion from two separate projects involving
      students and people with learning disabilities will be integrated into the paper.
      EPICURE (Engagement, Processing, Interpretation, Critique, Usefulness, Relevance 
      and Ethics (Stige et al. 2009) is adopted as a qualitative framework throughout
      the paper to evaluate the reported work that took place between September 2006
      and October 2010. Suggestions are therefore made regarding the benefits and
      challenges of striving towards an inclusive approach to user involvement in nurse
      education, with particular reference to learning disability. The work presented
      in the paper demonstrates how through careful involvement of this population,
      deeper learning opportunities for all nursing students can be created.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Bollard, Martin
AU  - Bollard M
AD  - Faculty of Health and Life Sciences, Richard Crossman Building, Coventry
      University, Priory Street, CV1 5FB, UK. Martin.bollard@coventry.ac.k
FAU - Lahiff, John
AU  - Lahiff J
FAU - Parkes, Neville
AU  - Parkes N
LA  - eng
PT  - Journal Article
DEP - 20111027
PL  - Scotland
TA  - Nurse Educ Today
JT  - Nurse education today
JID - 8511379
MH  - Education, Nursing/*methods
MH  - Humans
MH  - Learning Disabilities/*nursing
MH  - Nursing Education Research
MH  - Nursing Evaluation Research
MH  - Nursing Methodology Research
MH  - *Patient Participation
EDAT- 2011/11/01 06:00
MHDA- 2012/05/15 06:00
CRDT- 2011/11/01 06:00
PHST- 2011/02/17 00:00 [received]
PHST- 2011/08/30 00:00 [revised]
PHST- 2011/10/03 00:00 [accepted]
PHST- 2011/11/01 06:00 [entrez]
PHST- 2011/11/01 06:00 [pubmed]
PHST- 2012/05/15 06:00 [medline]
AID - S0260-6917(11)00251-6 [pii]
AID - 10.1016/j.nedt.2011.10.002 [doi]
PST - ppublish
SO  - Nurse Educ Today. 2012 Feb;32(2):173-7. doi: 10.1016/j.nedt.2011.10.002. Epub
      2011 Oct 27.


PMID- 22035536
OWN - NLM
STAT- MEDLINE
DCOM- 20120224
LR  - 20131101
IS  - 1540-7586 (Electronic)
IS  - 0734-7332 (Linking)
VI  - 29
IP  - 6
DP  - 2011
TI  - Death ideation in cancer patients: contributing factors.
PG  - 636-42
LID - 10.1080/07347332.2011.615381 [doi]
AB  - Advances in cancer research and therapy have improved prognosis and the quality
      of life of many patients. However, previous epidemiological studies in oncologic 
      patients have shown an increased risk of suicide. Suicidal thoughts, relatively
      well known in those terminally ill, may be just as important for cancer patients 
      who are survivors or are living with the disease. Nonetheless, there is a
      relative paucity of data about suicidality in this setting. The authors conducted
      a prospective observational study to identify death thoughts and to explore the
      factors associated with suicidal ideation in cancer patients. A sample of 130
      patients referred for psychiatric consultation was obtained following informed
      consent and authorization from the local ethics committee. A semistructured
      interview assessed sociodemographic data, psychosocial support, and information
      regarding the cancer process and its treatment. Psychometric instruments were
      used to evaluate psychopathology, namely the Hospital Anxiety and Depression
      Scale, the Beck Hopelessness Scale, and the Beck Scale for Suicide Ideation.
      Psychiatric diagnoses were obtained through the application of the Mini
      International Neuropsychiatric Interview. Death ideation was identified in 34.6% 
      of patients, yet only 10% had active suicidal thoughts. Risk of suicide was
      associated with female gender, a psychiatric diagnosis (major depressive
      disorder, panic disorder, or dysthymia), difficult interpersonal relationships,
      associated pain, high hopelessness, and depressive and anxiety symptoms. Although
      suicidal thoughts are frequent in cancer patients at different stages of disease,
      most are transitory. Risk factors for suicidal ideation have been identified,
      such as depression, hopelessness, uncontrolled pain, and difficult interpersonal 
      relationships. Further assessment is necessary to identify those at higher risk
      of attempting suicide, and underlying psychiatric disorders should be vigorously 
      treated.
FAU - Madeira, Nuno
AU  - Madeira N
AD  - Servico de Psiquiatria-Hospitais da Universidade de Coimbra, Portugal.
      nunomadeira@huc.min-saude.pt
FAU - Albuquerque, Emilia
AU  - Albuquerque E
FAU - Santos, Tiago
AU  - Santos T
FAU - Mendes, Alexandre
AU  - Mendes A
FAU - Roque, Marta
AU  - Roque M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Psychosoc Oncol
JT  - Journal of psychosocial oncology
JID - 8309337
SB  - IM
MH  - Adult
MH  - *Attitude to Death
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/*psychology
MH  - Observation
MH  - Prospective Studies
MH  - Psychiatric Status Rating Scales
MH  - Risk Factors
MH  - *Suicidal Ideation
EDAT- 2011/11/01 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/11/01 06:00
PHST- 2011/11/01 06:00 [entrez]
PHST- 2011/11/01 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - 10.1080/07347332.2011.615381 [doi]
PST - ppublish
SO  - J Psychosoc Oncol. 2011;29(6):636-42. doi: 10.1080/07347332.2011.615381.


PMID- 22035427
OWN - NLM
STAT- MEDLINE
DCOM- 20120301
LR  - 20211020
IS  - 1471-2393 (Electronic)
IS  - 1471-2393 (Linking)
VI  - 11
DP  - 2011 Oct 29
TI  - Comparison of midwife-led and consultant-led care of healthy women at low risk of
      childbirth complications in the Republic of Ireland: a randomised trial.
PG  - 85
LID - 10.1186/1471-2393-11-85 [doi]
AB  - BACKGROUND: No midwifery-led units existed in Ireland before 2004. The aim of
      this study was to compare midwife-led (MLU) versus consultant-led (CLU) care for 
      healthy, pregnant women without risk factors for labour and delivery. METHODS: An
      unblinded, pragmatic randomised trial was designed, funded by the Health Service 
      Executive (Dublin North-East). Following ethical approval, all women booking
      prior to 24 weeks of pregnancy at two maternity hospitals with 1,300-3,200 births
      annually in Ireland were assessed for trial eligibility.1,653 consenting women
      were centrally randomised on a 2:1 ratio to MLU or CLU care, (1101:552).
      'Intention-to-treat' analysis was used to compare 9 key neonatal and maternal
      outcomes. RESULTS: No statistically significant difference was found between MLU 
      and CLU in the seven key outcomes: caesarean birth (163 [14.8%] vs 84 [15.2%];
      relative risk (RR) 0.97 [95% CI 0.76 to 1.24]), induction (248 [22.5%] vs 138
      [25.0%]; RR 0.90 [0.75 to 1.08]), episiotomy (126 [11.4%] vs 68 [12.3%]; RR 0.93 
      [0.70 to 1.23]), instrumental birth (139 [12.6%] vs 79 [14.3%]; RR 0.88 [0.68 to 
      1.14]), Apgar scores < 8 (10 [0.9%] vs 9 [1.6%]; RR 0.56 [0.23 to 1.36]),
      postpartum haemorrhage (144 [13.1%] vs 75 [13.6%]; RR 0.96 [0.74 to 1.25]);
      breastfeeding initiation (616 [55.9%] vs 317 [57.4%]; RR 0.97 [0.89 to 1.06]).
      MLU women were significantly less likely to have continuous electronic fetal
      monitoring (397 [36.1%] vs 313 [56.7%]; RR 0.64 [0.57 to 0.71]), or augmentation 
      of labour (436 [39.6%] vs 314 [56.9%]; RR 0.50 [0.40 to 0.61]). CONCLUSIONS:
      Midwife-led care, as practised in this study, is as safe as consultant-led care
      and is associated with less intervention during labour and delivery.
FAU - Begley, Cecily
AU  - Begley C
AD  - School of Nursing and Midwifery, Trinity College Dublin, Ireland. cbegley@tcd.ie
FAU - Devane, Declan
AU  - Devane D
FAU - Clarke, Mike
AU  - Clarke M
FAU - McCann, Colette
AU  - McCann C
FAU - Hughes, Patricia
AU  - Hughes P
FAU - Reilly, Mary
AU  - Reilly M
FAU - Maguire, Roisin
AU  - Maguire R
FAU - Higgins, Shane
AU  - Higgins S
FAU - Finan, Alan
AU  - Finan A
FAU - Gormally, Siobhan
AU  - Gormally S
FAU - Doyle, Miriam
AU  - Doyle M
LA  - eng
SI  - ISRCTN/ISRCTN14973283
GR  - G0901530/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20111029
PL  - England
TA  - BMC Pregnancy Childbirth
JT  - BMC pregnancy and childbirth
JID - 100967799
SB  - IM
CIN - Midwives. 2012;15(1):21. PMID: 24868667
MH  - Adult
MH  - Apgar Score
MH  - *Delivery of Health Care
MH  - Female
MH  - Hospitals, Maternity
MH  - Humans
MH  - Infant, Newborn
MH  - Ireland/epidemiology
MH  - *Maternal Health Services
MH  - *Midwifery
MH  - *Obstetrics
MH  - Pregnancy
MH  - Pregnancy Complications/*epidemiology/etiology/*prevention & control
MH  - Pregnancy Outcome
MH  - Risk Factors
PMC - PMC3226589
EDAT- 2011/11/01 06:00
MHDA- 2012/03/02 06:00
CRDT- 2011/11/01 06:00
PHST- 2011/07/25 00:00 [received]
PHST- 2011/10/29 00:00 [accepted]
PHST- 2011/11/01 06:00 [entrez]
PHST- 2011/11/01 06:00 [pubmed]
PHST- 2012/03/02 06:00 [medline]
AID - 1471-2393-11-85 [pii]
AID - 10.1186/1471-2393-11-85 [doi]
PST - epublish
SO  - BMC Pregnancy Childbirth. 2011 Oct 29;11:85. doi: 10.1186/1471-2393-11-85.


PMID- 22035342
OWN - NLM
STAT- MEDLINE
DCOM- 20120424
LR  - 20220129
IS  - 1464-410X (Electronic)
IS  - 1464-4096 (Linking)
VI  - 109
IP  - 7
DP  - 2012 Apr
TI  - Detailed analysis of operating time learning curves in robotic prostatectomy by a
      novice surgeon.
PG  - 1074-80
LID - 10.1111/j.1464-410X.2011.10665.x [doi]
AB  - OBJECTIVES: Structured mentor-led training programmes permit the safe
      introduction of novice trainees to robotic-assisted laparoscopic prostatectomy
      (RALP). We outline the first description of parallel learning curves for
      individual surgical steps and quantify the relative difficulty of each step to
      propose an order of training in our structured mentoring programme. PATIENTS AND 
      METHODS: A prospective ethically approved database was used to evaluate the
      operating times of each individual surgical step, in the first 150 RALP cases
      performed independently by a robotic-naive laparoscopic surgeon. Linear
      regression analysis was used to quantify the effect of surgeon experience on the 
      operating time for each individual surgical step. RESULTS: Univariate linear
      regression analysis revealed significant reductions in operating time over the
      first 150 cases for all of the RALP steps, with the exception of the Rocco
      stitch. Multivariate linear regression analysis compensated for confounding
      variables and led to the identification of five surgical steps in which the
      operating time of each was significantly influenced by experience of the
      procedure. The most substantial improvement in operating time was seen in the
      bladder take down step. After taking into account the multivariate regression
      model, standardized univariate coefficients allowed an order of training to be
      identified for future RALP novices, of increasing complexity rather than order of
      surgery, beginning with the bladder take down step and ending with the
      vesico-urethral anastomosis. CONCLUSIONS: We can begin the training of new
      robotic-naive surgeons at simpler surgical steps, in which the greatest gains in 
      expediency are made. We anticipate that identifying the more challenging surgical
      steps from this study and targeting training towards them may expedite our future
      trainees' proficiency at RALP.
CI  - (c) 2011 THE AUTHORS. BJU INTERNATIONAL (c) 2011 BJU INTERNATIONAL.
FAU - Dev, Harveer
AU  - Dev H
AD  - St John's College, University of Cambridge, Cambridge, UK.
FAU - Sharma, Naomi L
AU  - Sharma NL
FAU - Dawson, Sarah N
AU  - Dawson SN
FAU - Neal, David E
AU  - Neal DE
FAU - Shah, Nimish
AU  - Shah N
LA  - eng
GR  - G0900871/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
DEP - 20111028
PL  - England
TA  - BJU Int
JT  - BJU international
JID - 100886721
SB  - IM
MH  - General Surgery/education
MH  - Humans
MH  - Laparoscopy/*education
MH  - *Learning Curve
MH  - Male
MH  - Middle Aged
MH  - Prostatectomy/*education
MH  - Robotics/*education
MH  - Time Factors
EDAT- 2011/11/01 06:00
MHDA- 2012/04/25 06:00
CRDT- 2011/11/01 06:00
PHST- 2011/11/01 06:00 [entrez]
PHST- 2011/11/01 06:00 [pubmed]
PHST- 2012/04/25 06:00 [medline]
AID - 10.1111/j.1464-410X.2011.10665.x [doi]
PST - ppublish
SO  - BJU Int. 2012 Apr;109(7):1074-80. doi: 10.1111/j.1464-410X.2011.10665.x. Epub
      2011 Oct 28.


PMID- 22035225
OWN - NLM
STAT- MEDLINE
DCOM- 20120913
LR  - 20220321
IS  - 1471-6712 (Electronic)
IS  - 0283-9318 (Linking)
VI  - 26
IP  - 2
DP  - 2012 Jun
TI  - Finally, it became too much - experiences and reflections in the aftermath of
      attempted suicide.
PG  - 304-12
LID - 10.1111/j.1471-6712.2011.00934.x [doi]
AB  - The purpose of the study was to explore the experiences of persons after suicidal
      crises or recently completed suicide attempts. The research question was 'What
      thoughts do suicidal patients have about the crises they have experienced?'
      Hermeneutic approach, inspired by Gadamer, has characterized the process of
      collection, analysis and interpretation of data. Data were collected using
      qualitative research interviews. Ten participants, six men, 25-52 years old, and 
      four women, 21-45 years old, were informed and requested by specialists in
      psychology at emergency or subemergency psychiatric wards or by crisis resolution
      teams. Nine of the participants had experienced one or more suicide attempts. One
      person had been prevented in the attempt, by hospitalization in an emergency
      ward. This type of research requires sensitivity in the interview situation,
      where ethical responsibilities take precedence over research interests. Results
      obtained through a thematic analysis of six phases revealed five themes to be
      central: (i) Losing touch with the world, (ii) Relationship between the suicidal 
      accident and life history, (iii) Struggling for death and life (iv) An open door 
      as consolation and (v) Feeling shame and guilt. Being suicidal seems like a
      struggle in solitude, between longing to escape from suffering through death and 
      longing for love, safety and dignity in life. Suicidal accidents happen when
      suffering becomes intolerable. Suicide rarely occurs without a struggle and
      consideration of moral conflicts. The thought of suicide can provide consolation 
      and comfort to go on living. Shame seems to appear when a person cannot cope with
      her/his own life, and because of failed attempts, while guilt seems related to
      hurting other people.
CI  - (c) 2011 The Authors. Scandinavian Journal of Caring Sciences (c) 2011 Nordic
      College of Caring Science.
FAU - Vatne, May
AU  - Vatne M
AD  - Oslo and Akershus University College, Institute of Nursing, Oslo, Norway.
      may.vatne@hioa.no
FAU - Naden, Dagfinn
AU  - Naden D
LA  - eng
PT  - Journal Article
DEP - 20111028
PL  - Sweden
TA  - Scand J Caring Sci
JT  - Scandinavian journal of caring sciences
JID - 8804206
MH  - Adult
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Suicide, Attempted/*psychology
EDAT- 2011/11/01 06:00
MHDA- 2012/09/14 06:00
CRDT- 2011/11/01 06:00
PHST- 2011/11/01 06:00 [entrez]
PHST- 2011/11/01 06:00 [pubmed]
PHST- 2012/09/14 06:00 [medline]
AID - 10.1111/j.1471-6712.2011.00934.x [doi]
PST - ppublish
SO  - Scand J Caring Sci. 2012 Jun;26(2):304-12. doi: 10.1111/j.1471-6712.2011.00934.x.
      Epub 2011 Oct 28.


PMID- 31508094
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1749-3676 (Print)
IS  - 1749-3676 (Linking)
VI  - 8
IP  - 4
DP  - 2011 Nov
TI  - Subthreshold psychiatry.
PG  - 79-81
AB  - Are we in need of including in our diagnostic systems a new category of
      subthreshold psychiatry? Studies have shown that we are faced in our daily
      clinical practice with many patients who do not fulfil the criteria of either
      ICD-10 or DSM-IV (at best they may be included under 'atypical', 'unspecified' or
      'not elsewhere classified'). Subthreshold cases or prodromal psychotic or
      non-psychotic clinical cases are encountered frequently in clinical practice,
      especially primary care (Knappe et al, 2008), but because of some ethical and
      nosological issues their needs are unmet. Pharmacological interventions for such 
      conditions are denied in some countries, especially with managed care, where
      maximisation of profit and minimisation of cost are often the main objectives. It
      has been reported that the early treatment of many disorders ensures a better
      outcome and better assimilation in society and reduces residual manifestations of
      disease. Recent data suggest that the impairment and disability caused by
      subsyndromal disorders are almost equal to those caused by syndromal ones. We
      need more scientific data and research studies to evaluate the course, outcome
      and value of treating such disorders.
FAU - Okasha, Ahmed
AU  - Okasha A
AD  - Director, WHO Collaborating Center for Research and Training in Mental Health,
      Okasha Institute of Psychiatry, Ain Shams University, Egypt, email
      aokasha@internetegypt.com.
LA  - eng
PT  - Editorial
DEP - 20111101
PL  - England
TA  - Int Psychiatry
JT  - International psychiatry : bulletin of the Board of International Affairs of the 
      Royal College of Psychiatrists
JID - 101189664
PMC - PMC6735034
EDAT- 2011/11/01 00:00
MHDA- 2011/11/01 00:01
CRDT- 2019/09/12 06:00
PHST- 2019/09/12 06:00 [entrez]
PHST- 2011/11/01 00:00 [pubmed]
PHST- 2011/11/01 00:01 [medline]
PST - epublish
SO  - Int Psychiatry. 2011 Nov 1;8(4):79-81. eCollection 2011 Nov.


PMID- 30013266
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 0024-3639 (Print)
IS  - 0024-3639 (Linking)
VI  - 78
IP  - 4
DP  - 2011 Nov
TI  - The Catholic Church in America, the Discipline of Bioethics, and the Culture of
      Life: Looking to the Encyclical Evangelium Vitae for Guidance.
PG  - 415-436
LID - 10.1080/002436311803888221 [doi]
AB  - In this paper, I will first briefly discuss why the Catholic Church has always
      had and continues to have such a great concern for bioethics or health-care
      ethics, while I also highlight the biblical roots of this concern. Secondly, I
      will describe some of the ways in which the Catholic Church in America has
      exercised a positive influence in the field of bioethics, or what was in the
      mid-twentieth century often called medical ethics. Thirdly, I will sketch how and
      why the Church has to a large extent lost this influence, tracing how
      secularization both inside and outside the Church contributed to the destruction 
      of the so-called "Catholic ghetto" and to the assimilation of ideas from the
      culture that were often alien to the Gospel and sound moral reasoning. Finally, I
      will offer some general reflections on how the Church can regain her influence in
      this area-especially with the goal in mind of building a culture of life in
      American society-and how Catholic scholars in particular can contribute to this
      effort by following the lead of the late Pope John Paul II's 1995 encyclical on
      bioethics, Evangelium vitae, whose twentieth anniversary is fast approaching.
FAU - Latkovic, Mark S
AU  - Latkovic MS
AD  - Sacred Heart Major Seminary in Detroit, Michigan.
LA  - eng
PT  - Journal Article
DEP - 20111101
PL  - United States
TA  - Linacre Q
JT  - The Linacre quarterly
JID - 2985221R
PMC - PMC6044515
EDAT- 2011/11/01 00:00
MHDA- 2011/11/01 00:01
CRDT- 2018/07/18 06:00
PHST- 2018/07/18 06:00 [entrez]
PHST- 2011/11/01 00:00 [pubmed]
PHST- 2011/11/01 00:01 [medline]
AID - 10.1080/002436311803888221 [doi]
AID - 10.1080_002436311803888221 [pii]
PST - ppublish
SO  - Linacre Q. 2011 Nov;78(4):415-436. doi: 10.1080/002436311803888221. Epub 2011 Nov
      1.


PMID- 30013264
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 0024-3639 (Print)
IS  - 0024-3639 (Linking)
VI  - 78
IP  - 4
DP  - 2011 Nov
TI  - The Moral Obligation of Nutrition and Hydration in the Tradition and Magisterium 
      of the Catholic Church: A Look at the Debate in the United States of America.
PG  - 381-400
LID - 10.1080/002436311803888186 [doi]
AB  - The recent publication of the fifth edition of the Ethical and Religious
      Directives for Catholic Health Care Services on November 17, 2009, by mandate of 
      the United States bishops, witnessed the eruption of a controversy in the U.S.
      with regard to nutrition and hydration for the seriously ill and dying. Among the
      major philosophical and moral thinkers in the field, there are some on the one
      hand who-out of respect for the wishes of the patient as expressed in normal
      situations-see no need for nutrition and hydration if such are the patient's
      wishes, even though they may have been expressed before the patient became ill.
      On the other hand, there are those who-out of respect for human dignity and with 
      the understanding that any act of euthanasia is morally unacceptable-do not see
      how the interruption of life support can be acceptable unless it comes to be a
      burden and no longer a benefit under end-of-life conditions. In light of all
      this, the present article aims to provide reflections on the nature of assisted
      nutrition and hydration (ANH) and the obligation to use it in cases where
      clinical evidence requires it, with a particular focus on the ongoing bioethical 
      debate in the U.S.
FAU - Giovanelli, Giorgio
AU  - Giovanelli G
LA  - eng
PT  - Journal Article
DEP - 20111101
PL  - United States
TA  - Linacre Q
JT  - The Linacre quarterly
JID - 2985221R
PMC - PMC6044516
EDAT- 2011/11/01 00:00
MHDA- 2011/11/01 00:01
CRDT- 2018/07/18 06:00
PHST- 2018/07/18 06:00 [entrez]
PHST- 2011/11/01 00:00 [pubmed]
PHST- 2011/11/01 00:01 [medline]
AID - 10.1080/002436311803888186 [doi]
AID - 10.1080_002436311803888186 [pii]
PST - ppublish
SO  - Linacre Q. 2011 Nov;78(4):381-400. doi: 10.1080/002436311803888186. Epub 2011 Nov
      1.


PMID- 24298338
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20211021
IS  - 2005-3606 (Print)
IS  - 2005-3606 (Linking)
VI  - 4
IP  - 2
DP  - 2011 Nov
TI  - Science and ethics: bridge to the future for regenerative medicine.
PG  - 79-84
AB  - The objective of this article is to reflect on the relationship between
      regenerative medicine and ethics, using as references the Aristotelian concept of
      what is ethical and that of Raessler Van Potter about bioethics. To do this, I
      will briefly describe the advances in regenerative medicine with stem cells, the 
      strategies for producing pluripotential cells without destroying human embryos,
      and the great potential of stem cells to improve life for Humanity, noting that
      for this to be possible, it is necessary to locate the role of regenerative
      medicine in the context of human values and well being. In this way, this article
      has a real perspective of the role that regenerative medicine can play in
      benefitting human beings and engendering respect for human and natural
      environments.
FAU - Patricio, Ventura-Junca
AU  - Patricio VJ
AD  - Centro de Bioetica, Pontificia Universidad Catolica School of Medicine, Santiago,
      Chile.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Korea (South)
TA  - Int J Stem Cells
JT  - International journal of stem cells
JID - 101497587
PMC - PMC3840959
OTO - NOTNLM
OT  - Bioethics
OT  - Regenerative medicine
OT  - Science and human values
OT  - Stem cells
EDAT- 2011/11/01 00:00
MHDA- 2011/11/01 00:01
CRDT- 2013/12/04 06:00
PHST- 2011/09/10 00:00 [accepted]
PHST- 2013/12/04 06:00 [entrez]
PHST- 2011/11/01 00:00 [pubmed]
PHST- 2011/11/01 00:01 [medline]
AID - 10.15283/ijsc.2011.4.2.79 [doi]
PST - ppublish
SO  - Int J Stem Cells. 2011 Nov;4(2):79-84. doi: 10.15283/ijsc.2011.4.2.79.


PMID- 23672751
OWN - NLM
STAT- MEDLINE
DCOM- 20131031
LR  - 20130515
IS  - 1756-5391 (Electronic)
IS  - 1756-5391 (Linking)
VI  - 4
IP  - 4
DP  - 2011 Nov
TI  - Joint statement on promoting development of publication ethics among medical
      journals in China.
PG  - 214-6
LID - 10.1111/j.1756-5391.2011.01159.x [doi]
FAU - Wu, Taixiang
AU  - Wu T
AD  - Chinese Clinical Trial Registry, Chinese Ethics Committee of Registering Clinical
      Trials, Chinese Evidence-Based Medicine Centre, West China Hospital, Sichuan
      University, China.
FAU - Li, Youping
AU  - Li Y
FAU - Zhen, Shangwei
AU  - Zhen S
FAU - Deng, Shaolin
AU  - Deng S
FAU - Zhang, Linzhi
AU  - Zhang L
FAU - Fan, Chenfang
AU  - Fan C
FAU - Jia, Wannan
AU  - Jia W
FAU - Zhong, Zihong
AU  - Zhong Z
FAU - Du, Liang
AU  - Du L
FAU - Liu, Xuemei
AU  - Liu X
FAU - Zhou, Qinghui
AU  - Zhou Q
FAU - Xu, Yanli
AU  - Xu Y
FAU - Chen, Keji
AU  - Chen K
FAU - Bian, Zhaoxiang
AU  - Bian Z
FAU - Wong, Vivian
AU  - Wong V
CN  - Working Group for Development of Publication Ethics
LA  - eng
PT  - Guideline
PT  - Journal Article
PL  - England
TA  - J Evid Based Med
JT  - Journal of evidence-based medicine
JID - 101497477
SB  - IM
MH  - China
MH  - *Periodicals as Topic
MH  - Publishing/*ethics
EDAT- 2011/11/01 00:00
MHDA- 2013/11/01 06:00
CRDT- 2013/05/16 06:00
PHST- 2013/05/16 06:00 [entrez]
PHST- 2011/11/01 00:00 [pubmed]
PHST- 2013/11/01 06:00 [medline]
AID - 10.1111/j.1756-5391.2011.01159.x [doi]
PST - ppublish
SO  - J Evid Based Med. 2011 Nov;4(4):214-6. doi: 10.1111/j.1756-5391.2011.01159.x.


PMID- 23672750
OWN - NLM
STAT- MEDLINE
DCOM- 20131031
LR  - 20130515
IS  - 1756-5391 (Electronic)
IS  - 1756-5391 (Linking)
VI  - 4
IP  - 4
DP  - 2011 Nov
TI  - Improving health research governance and management in the Western Pacific: a WHO
      expert consultation.
PG  - 204-13
LID - 10.1111/j.1756-5391.2011.01161.x [doi]
AB  - Repeated calls have been made in recent decades to increase investments in health
      research, especially in low- and middle-income countries (LMIC). However, the
      perceived low relevance and quality of health research, poor visibility of
      outputs, and difficulties in tracking current levels of and returns on
      investments have undermined efforts to advocate for additional investments in
      these countries. Some of these issues emanate from inadequate governance and
      management systems for health research at the national level, which are
      ineffective in tracking and steering the research portfolio and investments,
      ensuring quality, and facilitating access to research outputs. In spite of this, 
      the value, necessity, and cost of performing health research management and
      governance functions are not well appreciated, especially in LMIC. To address
      this, the World Health Organization (WHO) Regional Office for the Western Pacific
      organized an expert consultation in August 2011, involving experts from 14 of its
      developed and developing member states and from leading research organizations
      such as the Wellcome Trust. The consultation identified essential health research
      governance and management functions that must be performed by appropriate
      organizational entities to maximize returns on health research investments. In
      addition, three specific areas for intervention were considered: (1) prospective 
      research registration in publicly accessible national health research registries;
      (2) systematic health research data archiving and wider access; and (3) national 
      research ethics systems. A consensus was reached on the need to invest more in
      essential health research and management functions, including establishing
      publicly accessible web-based national health research registries for prospective
      registration of health research, setting up systems to archive and share health
      research data, and improving the governance of research ethics committees. The
      consultation also concluded that the costs of performing these functions are
      legitimate and necessary research costs that must be shouldered by research
      funding organizations.
CI  - (c) 2011 Blackwell Publishing Asia Pty Ltd and Chinese Cochrane Center, West
      China Hospital of Sichuan University.
FAU - Rani, Manju
AU  - Rani M
AD  - Western Pacific Regional Office World Health Organization Corner Taft and UN
      Avenue, Manila-1000, Philippines. ranim@wpro.who.int
FAU - Bekedam, Hendrik
AU  - Bekedam H
FAU - Buckley, Brian S
AU  - Buckley BS
CN  - World Health Organization Regional Office for the Western Pacific
LA  - eng
PT  - Guideline
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Evid Based Med
JT  - Journal of evidence-based medicine
JID - 101497477
SB  - IM
MH  - Databases, Factual
MH  - Ethics, Research
MH  - Investments
MH  - Referral and Consultation
MH  - Registries
MH  - Research/*organization & administration
MH  - World Health Organization
EDAT- 2011/11/01 00:00
MHDA- 2013/11/01 06:00
CRDT- 2013/05/16 06:00
PHST- 2013/05/16 06:00 [entrez]
PHST- 2011/11/01 00:00 [pubmed]
PHST- 2013/11/01 06:00 [medline]
AID - 10.1111/j.1756-5391.2011.01161.x [doi]
PST - ppublish
SO  - J Evid Based Med. 2011 Nov;4(4):204-13. doi: 10.1111/j.1756-5391.2011.01161.x.


PMID- 23650670
OWN - NLM
STAT- MEDLINE
DCOM- 20130618
LR  - 20130508
IS  - 0034-8376 (Print)
IS  - 0034-8376 (Linking)
VI  - 63
IP  - 6
DP  - 2011 Nov-Dec
TI  - [Physician-patient with AIDS-relationship, as a model of clinical relation within
      the framework of the social security institutions in Mexico].
PG  - 574-89
AB  - OBJECTIVE: To examine the nature and level of physician involvement during a
      clinical encounter with a patient with a chronic condition, such as AIDS, and to 
      explore how it is understood and constructed by them. MATERIAL AND METHODS:
      Qualitative design with participant observation and semi-structured interviews,
      with physicians and patients, conducted in hospitals of Social Security
      Institutions in Mexico City Data were analyzed using the constant comparative
      method developed in the grounded theory tradition. The emergent themes studied
      were the dynamics of the encounters, levels of participation of the physician,
      and attitudes of both participants. RESULTS: Irrespective of whether patients
      were seen for the first time, or subsequently, in outpatient consultation or in
      hospital, the physician focused on the solution of the biological problem and on 
      the performance of a work commitment with the Institution. CONCLUSION: This study
      highlights the need to strengthen the incorporation of the ethics into daily
      clinical practice in order to transform a physician-patient relationship which is
      merely bureaucratic, focused on the solution of a biological problem and on the
      fulfillment of an institutional commitment, into a relationship which is truly
      professional and at the service of the patient.
FAU - Valdez-Martinez, Edith
AU  - Valdez-Martinez E
AD  - Coordinacion de Investigaci6n en Salud, Institute Mexicano del Seguro Social.
      edithvaldez@prodigy.net.mx
FAU - Bedolla, Miguel
AU  - Bedolla M
FAU - Rico, Rosalia
AU  - Rico R
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
TT  - Analisis de la naturaleza de la relacion medico-enfermo con SIDA en instituciones
      de seguridad social en Mexico.
PL  - Mexico
TA  - Rev Invest Clin
JT  - Revista de investigacion clinica; organo del Hospital de Enfermedades de la
      Nutricion
JID - 9421552
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/*psychology
MH  - *Attitude
MH  - Attitude of Health Personnel
MH  - Authoritarianism
MH  - Emotions
MH  - Empathy
MH  - Female
MH  - Hospitals, Public
MH  - Hospitals, Urban
MH  - Humans
MH  - Inpatients/psychology
MH  - Interview, Psychological
MH  - Male
MH  - Mexico
MH  - Models, Psychological
MH  - Outpatients/psychology
MH  - *Physician-Patient Relations/ethics
MH  - Physicians/psychology
MH  - Social Dominance
MH  - Social Security
MH  - Verbal Behavior
EDAT- 2011/11/01 00:00
MHDA- 2013/06/19 06:00
CRDT- 2013/05/09 06:00
PHST- 2013/05/09 06:00 [entrez]
PHST- 2011/11/01 00:00 [pubmed]
PHST- 2013/06/19 06:00 [medline]
PST - ppublish
SO  - Rev Invest Clin. 2011 Nov-Dec;63(6):574-89.


PMID- 22033855
OWN - NLM
STAT- MEDLINE
DCOM- 20131126
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 1
DP  - 2013 Mar
TI  - Hidden in plain view: feminists doing engineering ethics, engineers doing
      feminist ethics.
PG  - 189-206
LID - 10.1007/s11948-011-9320-0 [doi]
AB  - How has engineering ethics addressed gender concerns to date? How have the ideas 
      of feminist philosophers and feminist ethicists made their way into engineering
      ethics? What might an explicitly feminist engineering ethics look like? This
      paper reviews some major themes in feminist ethics and then considers three areas
      in which these themes have been taken up in engineering ethics to date. First,
      Caroline Whitbeck's work in engineering ethics integrates considerations from her
      own earlier writings and those of other feminist philosophers, but does not use
      the feminist label. Second, efforts to incorporate the Ethic of Care and
      principles of Social Justice into engineering have drawn on feminist scholarship 
      and principles, but these commitments can be lost in translation to the broader
      engineering community. Third, the film Henry's Daughters brings gender
      considerations into the mainstream of engineering ethics, but does not draw on
      feminist ethics per se; despite the best intentions in broaching a difficult
      subject, the film unfortunately does more harm than good when it comes to sexual 
      harassment education. I seek not only to make the case that engineers should pay 
      attention to feminist ethics and engineering ethicists make more use of feminist 
      ethics traditions in the field, but also to provide some avenues for how to
      approach integrating feminist ethics in engineering. The literature review and
      analysis of the three examples point to future work for further developing what
      might be called feminist engineering ethics.
FAU - Riley, Donna
AU  - Riley D
AD  - Picker Engineering Program, Smith College, Northampton, MA 01063, USA.
      driley@smith.edu
LA  - eng
PT  - Journal Article
DEP - 20111028
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Engineering/*ethics
MH  - *Ethics, Professional
MH  - Female
MH  - *Feminism
MH  - Humans
MH  - Male
MH  - *Morals
MH  - Motion Pictures
MH  - *Philosophy
MH  - Sexual Harassment
MH  - *Social Justice
EDAT- 2011/10/29 06:00
MHDA- 2013/12/16 06:00
CRDT- 2011/10/29 06:00
PHST- 2011/05/26 00:00 [received]
PHST- 2011/10/14 00:00 [accepted]
PHST- 2011/10/29 06:00 [entrez]
PHST- 2011/10/29 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1007/s11948-011-9320-0 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Mar;19(1):189-206. doi: 10.1007/s11948-011-9320-0. Epub 2011
      Oct 28.


PMID- 22033398
OWN - NLM
STAT- MEDLINE
DCOM- 20120928
LR  - 20181201
IS  - 1472-6491 (Electronic)
IS  - 1472-6483 (Linking)
VI  - 23
IP  - 7
DP  - 2011 Dec
TI  - Cross-border reproductive care: a clinician's perspective.
PG  - 808-10
LID - 10.1016/j.rbmo.2011.10.002 [doi]
AB  - Cross-border reproductive care (CBRC) is a means to an end. Nearly all patients' 
      reproductive journeys are designed to deliver them a child, which, for the
      multitude of reasons discussed in the last issue of this journal, has not been
      proven possible for them in their home country. Their journey pathways look like 
      the route maps in airline in-flight magazines, but at the end of their flight a
      medical procedure awaits, often involving a third-party donor or surrogate.
      Clinicians therefore are tightly involved in the delivery of CBRC, whether as
      service providers or service facilitators, and have a unique ethical
      responsibility to ensure that appropriate standards of care are provided to all
      those receiving treatment, be they patients or third-party providers. Several
      authors in the symposium issue are rightly critical of exploitation of third
      parties, particularly in the global south, although some are critical of the use 
      of third-party fertility treatment in principle. However, CBRC and the subsequent
      fragmentation of fertility treatment is likely to increase and doctors must be
      drivers for improvement of standards of reproductive medical care in the
      developing world, and elsewhere, as more countries and clinics seek to benefit
      economically from the expanding market in medical consumerism.
CI  - Copyright (c) 2011. Published by Elsevier Ltd.
FAU - Forman, Robert
AU  - Forman R
AD  - CRM London, 111 Park Road, London, United Kingdom. RobertForman@crmlondon.co.uk
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20111008
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
SB  - IM
CON - Reprod Biomed Online. 2011 Jun;22(7):673-85. PMID: 21498121
MH  - Humans
MH  - *Medical Tourism
MH  - *Reproductive Techniques, Assisted
EDAT- 2011/10/29 06:00
MHDA- 2012/09/29 06:00
CRDT- 2011/10/29 06:00
PHST- 2011/10/04 00:00 [received]
PHST- 2011/10/04 00:00 [accepted]
PHST- 2011/10/29 06:00 [entrez]
PHST- 2011/10/29 06:00 [pubmed]
PHST- 2012/09/29 06:00 [medline]
AID - S1472-6483(11)00532-3 [pii]
AID - 10.1016/j.rbmo.2011.10.002 [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2011 Dec;23(7):808-10. doi: 10.1016/j.rbmo.2011.10.002.
      Epub 2011 Oct 8.


PMID- 22033377
OWN - NLM
STAT- MEDLINE
DCOM- 20120405
LR  - 20181201
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 73
IP  - 12
DP  - 2011 Dec
TI  - "The Most Important Test You'll Ever Take"?: attitudes toward confidential
      carrier matching and open individual testing among modern-religious Jews in
      Israel.
PG  - 1741-7
LID - 10.1016/j.socscimed.2011.09.031 [doi]
AB  - This article reports on attitudes of modern-religious Ashkenazi Jewish adults in 
      Israel toward anonymous carrier matching for severe monogenic diseases by Dor
      Yesharim (the ultra-orthodox organization) and open individual carrier testing
      (through a medical center), examining how this important choice is being
      informed, communicated, made, and reflected on. Qualitative analysis of
      semi-structured interviews conducted with 23 modern-religious Ashkenazi Jews in
      2009-2011 revealed social pressure to utilize Dor Yesharim; however, respondents 
      considered its policy of advising against a marriage between partners who are
      carriers of the same genetic condition inappropriate for 'love marriages' where a
      couple's commitment may already be made. Confidential carrier testing was a
      stepping stone to open carrier testing for those advised not to marry.
      Respondents varied in their views on when open carrier tests should be conducted.
      Pre-implantation genetic diagnosis was considered religiously preferable to
      abortion; however most carrier couples opted for pre-natal testing and selective 
      abortion, challenging stereotypes about the attitudes of religious Jews. It is
      discussed how carrier screening is contextualized and interpreted not just in
      terms of religious teachings, but in interaction with lay agency, personal
      experiences and knowledge of reproductive choices. We conclude by discussing the 
      implications for the social analysis of the ethics of carrier screening in
      religious communities at risk.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Frumkin, Ayala
AU  - Frumkin A
AD  - Monique and Jacques Roboh Department of Genetic Research, The Department of
      Genetic and Metabolic Diseases, Hadassah, Hebrew University Medical Center,
      Jerusalem 91120, Israel.
FAU - Raz, Aviad E
AU  - Raz AE
FAU - Plesser-Duvdevani, Morasha
AU  - Plesser-Duvdevani M
FAU - Lieberman, Sari
AU  - Lieberman S
LA  - eng
PT  - Journal Article
DEP - 20111019
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Adult
MH  - Family Planning Services
MH  - Female
MH  - *Genetic Carrier Screening
MH  - Genetic Predisposition to Disease/*ethnology
MH  - *Genetic Testing/methods/statistics & numerical data
MH  - Humans
MH  - Interviews as Topic
MH  - Israel
MH  - Jews/genetics/*psychology
MH  - Male
MH  - Patient Acceptance of Health Care/*ethnology
MH  - Young Adult
EDAT- 2011/10/29 06:00
MHDA- 2012/04/06 06:00
CRDT- 2011/10/29 06:00
PHST- 2011/06/07 00:00 [received]
PHST- 2011/09/27 00:00 [revised]
PHST- 2011/09/27 00:00 [accepted]
PHST- 2011/10/29 06:00 [entrez]
PHST- 2011/10/29 06:00 [pubmed]
PHST- 2012/04/06 06:00 [medline]
AID - S0277-9536(11)00603-4 [pii]
AID - 10.1016/j.socscimed.2011.09.031 [doi]
PST - ppublish
SO  - Soc Sci Med. 2011 Dec;73(12):1741-7. doi: 10.1016/j.socscimed.2011.09.031. Epub
      2011 Oct 19.


PMID- 22033045
OWN - NLM
STAT- MEDLINE
DCOM- 20120605
LR  - 20211020
IS  - 1558-1527 (Electronic)
IS  - 1558-1527 (Linking)
VI  - 83
IP  - 1
DP  - 2012 Jan
TI  - A survey of optometry leadership: participation in disaster response.
PG  - 27-32
LID - 10.1016/j.optm.2011.06.012 [doi]
AB  - BACKGROUND: A study was completed to assess the academic and state-level
      professional optometry leadership views regarding optometry professionals as
      surge responders in the event of a catastrophic event. METHODS: A cross-sectional
      survey was conducted using a 21-question, self-administered, structured
      questionnaire. All U.S. optometry school deans and state optometric association
      presidents were mailed a questionnaire and instructions to return it by mail on
      completion; 2 repeated mailings were made. Descriptive statistics were produced
      and differences between deans and association presidents were tested by Fisher
      exact test. RESULTS: The questionnaire response rate was 50% (25 returned/50
      sent) for the state association presidents and 65% (11/17) for the deans. There
      were no statistically significant differences between the leadership groups for
      any survey questions. All agreed that optometrists have the skills, are ethically
      obligated to help, and that optometrists should receive additional training for
      participation in disaster response. There was general agreement that optometrists
      should provide first-aid, obtain medical histories, triage, maintain infection
      control, manage a point of distribution, prescribe medications, and counsel the
      "worried well." Starting intravenous lines, interpreting radiographs, and
      suturing were less favorably supported. There was some response variability
      between the 2 leadership groups regarding potential sources for training.
      CONCLUSIONS: The overall opinion of optometry professional leadership is that
      with additional training, optometrists can and should provide an important
      reserve pool of catastrophic event responders.
CI  - Copyright (c) 2011 American Optometric Association. Published by Elsevier Inc.
      All rights reserved.
FAU - Psoter, Walter J
AU  - Psoter WJ
AD  - New York University College of Dentistry, Department of Epidemiology & Health
      Promotion, New York, New York 10003, USA. wp9@nyu.edu
FAU - Glotzer, David L
AU  - Glotzer DL
FAU - Weiserbs, Kera Fay
AU  - Weiserbs KF
FAU - Baek, Linda S
AU  - Baek LS
FAU - Karloopia, Rajiv
AU  - Karloopia R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20111026
PL  - United States
TA  - Optometry
JT  - Optometry (St. Louis, Mo.)
JID - 100912421
SB  - IM
MH  - Cross-Sectional Studies
MH  - Disaster Planning/*organization & administration
MH  - *Disasters
MH  - Humans
MH  - *Leadership
MH  - Optometry/*education
MH  - *Surveys and Questionnaires
MH  - United States
PMC - PMC7106212
EDAT- 2011/10/29 06:00
MHDA- 2012/06/06 06:00
CRDT- 2011/10/29 06:00
PHST- 2011/04/10 00:00 [received]
PHST- 2011/06/14 00:00 [accepted]
PHST- 2011/10/29 06:00 [entrez]
PHST- 2011/10/29 06:00 [pubmed]
PHST- 2012/06/06 06:00 [medline]
AID - S1529-1839(11)00453-2 [pii]
AID - 10.1016/j.optm.2011.06.012 [doi]
PST - ppublish
SO  - Optometry. 2012 Jan;83(1):27-32. doi: 10.1016/j.optm.2011.06.012. Epub 2011 Oct
      26.


PMID- 22032673
OWN - NLM
STAT- MEDLINE
DCOM- 20120227
LR  - 20111028
IS  - 1557-9875 (Electronic)
IS  - 0733-8619 (Linking)
VI  - 29
IP  - 4
DP  - 2011 Nov
TI  - Ethical aspects of disordered states of consciousness.
PG  - 1055-71
LID - 10.1016/j.ncl.2011.07.007 [doi]
AB  - The medical care of patients in disordered states of consciousness, including
      vegetative and minimally conscious states, raises some of the most intricate
      ethical questions in medicine. There is inherent ambiguity and uncertainty
      involved in diagnosing such patients and evaluating their level of awareness and 
      prognosis for recovery. The care of these patients requires the weighing of
      competing ethical values, including respect for personal autonomy, protection of 
      vulnerable patients, nonmaleficence, and the just use of limited medical
      resources. We highlight some of the major ethical issues in caring for patients
      with severe brain injury.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Rubin, Emily B
AU  - Rubin EB
AD  - Internal Medicine and Pediatrics, Massachusetts General Hospital, 55 Fruit
      Street, Boston, MA 02114, USA. erubin3@partners.org
FAU - Bernat, James L
AU  - Bernat JL
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Neurol Clin
JT  - Neurologic clinics
JID - 8219232
SB  - IM
MH  - *Consciousness
MH  - Consciousness Disorders/*diagnosis/physiopathology
MH  - *Ethics, Medical
MH  - Humans
EDAT- 2011/10/29 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/10/29 06:00
PHST- 2011/10/29 06:00 [entrez]
PHST- 2011/10/29 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - S0733-8619(11)00053-3 [pii]
AID - 10.1016/j.ncl.2011.07.007 [doi]
PST - ppublish
SO  - Neurol Clin. 2011 Nov;29(4):1055-71. doi: 10.1016/j.ncl.2011.07.007.


PMID- 22032551
OWN - NLM
STAT- MEDLINE
DCOM- 20120130
LR  - 20220321
IS  - 1751-7893 (Electronic)
IS  - 1751-7885 (Linking)
VI  - 5
IP  - 4
DP  - 2011 Nov
TI  - Prevalence of suicide risk factors in people at ultra-high risk of developing
      psychosis: a service audit.
PG  - 375-80
LID - 10.1111/j.1751-7893.2011.00302.x [doi]
AB  - BACKGROUND: Little data is available on the prevalence of suicide risk factors in
      people at ultra-high risk (UHR) of developing psychosis. AIM: The aim of this
      study was to provide an estimate of the cross-sectional prevalence of possible
      suicide risk factors in those attending a routine clinical service for people at 
      UHR of developing psychosis. METHODS: For all patients in treatment (n=34) over a
      4-week period, levels of suicidal ideation and depression upon entry to the
      service were assessed by auditing intake scores on the Beck Depression Inventory,
      second edition. Level of engagement with services, social isolation, substance
      and alcohol misuse, ready access to means, current suicidal ideation, previous
      suicide attempts, current or previous self-harm, expressions of concern from
      others, depression, agitation, hopelessness, worthlessness, suspiciousness and
      fears of mental disintegration were all assessed by case note review and
      interview with the treating clinician. RESULTS: There was a high prevalence of at
      least mild suicidal ideation (58.8%, n=20) and severe depressed mood (47%, n=16) 
      in this client group at point of entry to the service. Seven people (20.6%) had
      engaged in serious self-harm (including attempted suicide) during the time they
      were in contact with the service. Forty-seven per cent (n=16) reported at least
      27 suicide attempts between them; the mean number of attempts being 1.69
      (standard deviation=1.08). CONCLUSION: Suicide risk was high in this small sample
      of people at UHR of developing psychosis. Controlled research with larger samples
      and better methodology is urgently required to inform legal, ethical and
      scientific debates surrounding this group.
CI  - (c) 2011 Blackwell Publishing Asia Pty Ltd.
FAU - Hutton, Paul
AU  - Hutton P
AD  - Psychosis Research Unit (PRU) Early Detection and Intervention Team (EDIT),
      Greater Manchester West Mental Health Foundation NHS Trust, Bury New Road,
      Prestwich, Manchester, UK. paulhutton@nhs.net
FAU - Bowe, Samantha
AU  - Bowe S
FAU - Parker, Sophie
AU  - Parker S
FAU - Ford, Sarah
AU  - Ford S
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Early Interv Psychiatry
JT  - Early intervention in psychiatry
JID - 101320027
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cognitive Behavioral Therapy
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Medical Audit
MH  - Personality Inventory
MH  - Prevalence
MH  - Preventive Health Services
MH  - Psychiatric Status Rating Scales
MH  - Psychotic Disorders/*epidemiology/psychology/therapy
MH  - Risk Assessment
MH  - Risk Factors
MH  - Suicide/prevention & control/psychology/*statistics & numerical data
MH  - Young Adult
EDAT- 2011/10/29 06:00
MHDA- 2012/01/31 06:00
CRDT- 2011/10/29 06:00
PHST- 2011/10/29 06:00 [entrez]
PHST- 2011/10/29 06:00 [pubmed]
PHST- 2012/01/31 06:00 [medline]
AID - 10.1111/j.1751-7893.2011.00302.x [doi]
PST - ppublish
SO  - Early Interv Psychiatry. 2011 Nov;5(4):375-80. doi:
      10.1111/j.1751-7893.2011.00302.x.


PMID- 22032025
OWN - NLM
STAT- MEDLINE
DCOM- 20111123
LR  - 20211020
IS  - 1321-2753 (Print)
IS  - 1321-2753 (Linking)
VI  - 29
IP  - 3
DP  - 2011 Mar
TI  - Ethical tensions in genetic counselling research.
PG  - 07.1-12
AB  - Ethical tensions are recognised as part of the everyday practice of conducting
      research and practising genetic counselling. What are the conceptual frameworks
      that can assist researchers and genetic counsellors to deal with ethical tensions
      when conducting research? How might the overlap that arises from being a
      researcher and clinical genetic counsellor be dealt with? This article uses a
      case study to consider the ethical tensions between conducting research in
      genetic counselling and maintaining a clinical practice as a genetic counsellor. 
      It examines the reconciliation of the dual roles of researcher and genetic
      counsellor. It explores conceptual frameworks that can combine the needs of
      ethical research practice, while maintaining ethical clinical practice.
FAU - Young, Mary-Anne
AU  - Young MA
AD  - Centre for Health and Society, University of Melbourne, Australia.
      mary-anne.young@petermac.org
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Monash Bioeth Rev
JT  - Monash bioethics review
JID - 100973394
SB  - IM
MH  - Breast Neoplasms/prevention & control
MH  - Confidentiality/ethics
MH  - *Ethics, Research
MH  - Female
MH  - Genetic Counseling/*ethics
MH  - Humans
MH  - Interprofessional Relations/ethics
MH  - Interviews as Topic
MH  - Mastectomy/psychology
MH  - *Professional Role
EDAT- 2011/10/29 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/10/29 06:00
PHST- 2011/10/29 06:00 [entrez]
PHST- 2011/10/29 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/BF03351326 [doi]
PST - ppublish
SO  - Monash Bioeth Rev. 2011 Mar;29(3):07.1-12. doi: 10.1007/BF03351326.


PMID- 22032024
OWN - NLM
STAT- MEDLINE
DCOM- 20111123
LR  - 20181201
IS  - 1321-2753 (Print)
IS  - 1321-2753 (Linking)
VI  - 29
IP  - 3
DP  - 2011 Mar
TI  - Balancing the act: The international migration of medical graduates.
PG  - 05.1-12
AB  - In this article I examine the phenomenon of international migration of medical
      graduates. The debate involving the ethical aspects of medical migration as well 
      as the obstacles faced by doctors to practice unreservedly in their host
      countries are addressed. The situation of Australia in this context is also
      scrutinised. Finally, I propose a series of strategies aimed at minimising the
      unfavourable consequences of the international migration of doctors. This
      commentary favours a reform in the way institutions and society respond to the
      process of medical migration and to the needs of migrant doctors. Continued
      research on this health care topic is required in order to identify the major
      factors that play a role in this process.
FAU - Zubaran, Carlos
AU  - Zubaran C
AD  - School of Medicine, University of Western Sydney, Australia.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Monash Bioeth Rev
JT  - Monash bioethics review
JID - 100973394
SB  - IM
MH  - Australia
MH  - Civil Rights
MH  - Emigration and Immigration/*trends
MH  - Foreign Medical Graduates/*ethics/trends
MH  - Health Workforce
MH  - Humans
MH  - Internationality
MH  - Prejudice
MH  - Social Welfare
EDAT- 2011/10/29 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/10/29 06:00
PHST- 2011/10/29 06:00 [entrez]
PHST- 2011/10/29 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PST - ppublish
SO  - Monash Bioeth Rev. 2011 Mar;29(3):05.1-12.


PMID- 22031811
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1861-8863 (Electronic)
IS  - 1861-8863 (Linking)
VI  - 7
DP  - 2011
TI  - The effectiveness of interventions in workplace health promotion as to maintain
      the working capacity of health care personal.
PG  - Doc06
LID - 10.3205/hta000097 [doi]
AB  - BACKGROUND: The increasing proportion of elderly people with respective care
      requirements and within the total population stands against aging personnel and
      staff reduction in the field of health care where employees are exposed to high
      load factors. Health promotion interventions may be a possibility to improve work
      situations and behavior. METHODS: A systematic literature search is conducted in 
      32 databases limited to English and German publications since 1990. Moreover,
      internet-searches are performed and the reference lists of identified articles
      are scanned. The selection of literature was done by two reviewers independently 
      according to inclusion and exclusion criteria. Data extraction and tables of
      evidence are verified by a second expert just like the assessment of risk of bias
      by means of the Cochrane Collaboration's tool. RESULTS: We identified eleven
      intervention studies and two systematic reviews. There were three randomized
      controlled trials (RCT) and one controlled trial without randomization (CCT) on
      the improvement of physical health, four RCT and two CCT on the improvement of
      psychological health and one RCT on both. Study duration ranged from four weeks
      to two years and the number of participants included from 20 to 345, with a
      median of 56. Interventions and populations were predominantly heterogeneous. In 
      three studies intervention for the improvement of physical health resulted in
      less complaints and increased strength and flexibility with statistically
      significant differences between groups. Regarding psychological health
      interventions lead to significantly decreased intake of analgesics, better stress
      management, coping with workload, communication skills and advanced training.
      DISCUSSION: Taking into consideration the small to very small sample sizes, other
      methodological flaws like a high potential of bias and poor quality of reporting 
      the validity of the results has to be considered as limited. Due to the
      heterogeneity of health interventions, study populations with differing job
      specializations and different lengths of study durations and follow-up periods,
      the comparison of results would not make sense. CONCLUSIONS: Further research is 
      necessary with larger sample sizes, with a sufficient study duration and
      follow-up, with a lower risk of bias, by considering of relevant quality criteria
      and with better reporting in publications.
FAU - Buchberger, Barbara
AU  - Buchberger B
AD  - University of Duisburg-Essen, Institute for Health Care Management and Research, 
      Essen, Germany.
FAU - Heymann, Romy
AU  - Heymann R
FAU - Huppertz, Hendrik
AU  - Huppertz H
FAU - Frieportner, Katharina
AU  - Frieportner K
FAU - Pomorin, Natalie
AU  - Pomorin N
FAU - Wasem, Jurgen
AU  - Wasem J
LA  - eng
PT  - Journal Article
DEP - 20110928
PL  - Germany
TA  - GMS Health Technol Assess
JT  - GMS health technology assessment
JID - 101276045
PMC - PMC3198117
OTO - NOTNLM
OT  - CCT
OT  - CT
OT  - EBM
OT  - Germany
OT  - HTA
OT  - HTA report
OT  - HTA-report
OT  - Health Technology Assessment
OT  - RCT
OT  - Work Schedule Tolerance
OT  - ability to work
OT  - absenteeism
OT  - academic review
OT  - accident
OT  - aged
OT  - behaviour-oriented
OT  - biomedical technology assessment
OT  - blinded
OT  - blinding
OT  - care
OT  - clinical trial
OT  - condition-oriented
OT  - controlled clinical trials as topic
OT  - cost analysis
OT  - cost control
OT  - cost reduction
OT  - cost-benefit analysis
OT  - cost-cutting
OT  - cost-effectiveness
OT  - costs
OT  - costs and cost analysis
OT  - decision making
OT  - demographic development
OT  - demography
OT  - diagnosis
OT  - economic aspect
OT  - economics
OT  - economics, medical
OT  - effectiveness
OT  - efficacy
OT  - efficiency
OT  - ethics
OT  - evidence-based medicine
OT  - fitness for employment
OT  - fitness for work
OT  - health economic studies
OT  - health economics
OT  - health education
OT  - health policy
OT  - health promotion/*
OT  - humans
OT  - judgment
OT  - juricical
OT  - medical assessment
OT  - medical costs
OT  - medical evaluation
OT  - mental health
OT  - meta analysis
OT  - meta analysis as topic
OT  - meta-analysis
OT  - methods
OT  - models, economic
OT  - nursing
OT  - nursing staff/*
OT  - nursing staff/psychology
OT  - nursing staff/standards
OT  - occupational health services
OT  - occupational health/*
OT  - orderlies
OT  - pathogenesis
OT  - peer review
OT  - pharmaeconomics
OT  - physical health
OT  - placebo
OT  - placebo effect
OT  - placebos
OT  - population development
OT  - prevention
OT  - primary prevention
OT  - random
OT  - random allocation
OT  - randomisation
OT  - randomised clinical study
OT  - randomised clinical trial
OT  - randomised controlled study
OT  - randomised controlled trial
OT  - randomised study
OT  - randomised trial
OT  - randomization
OT  - randomized clinical study
OT  - randomized clinical trial
OT  - randomized controlled study
OT  - randomized controlled trials as topic
OT  - randomized study
OT  - randomized trial
OT  - rehabilitation
OT  - report
OT  - research article
OT  - review
OT  - review literature
OT  - review literature as topic
OT  - rigths
OT  - risk assessment
OT  - risk of bias tool
OT  - salutogenesis
OT  - sensitivity
OT  - sickness costs
OT  - social economic factors
OT  - socioeconomic factors
OT  - socioeconomics
OT  - specifity
OT  - systematic review
OT  - technical report
OT  - technology
OT  - technology assessment
OT  - technology assessment, biomedical
OT  - technology evaluation
OT  - technology, medical
OT  - terms and condition of employment
OT  - therapy
OT  - treatment
OT  - workableness
OT  - working conditions
OT  - workload
OT  - workplace health promotion
EDAT- 2011/10/28 06:00
MHDA- 2011/10/28 06:01
CRDT- 2011/10/28 06:00
PHST- 2011/10/28 06:00 [entrez]
PHST- 2011/10/28 06:00 [pubmed]
PHST- 2011/10/28 06:01 [medline]
AID - 10.3205/hta000097 [doi]
AID - hta000097 [pii]
PST - ppublish
SO  - GMS Health Technol Assess. 2011;7:Doc06. doi: 10.3205/hta000097. Epub 2011 Sep
      28.


PMID- 22031710
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20220309
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 261
IP  - 3
DP  - 2011 Dec
TI  - Clinical implications of MR imaging findings in the white matter in very preterm 
      infants: a 2-year follow-up study.
PG  - 899-906
LID - 10.1148/radiol.11110797 [doi]
AB  - PURPOSE: To explore the association between diffuse excessive high signal
      intensity (DEHSI), punctate white matter (WM) lesions, and ventricular dilatation
      around term-equivalent age (TEA) and at clinical follow-up at 2 years in very
      preterm infants and the effect on neurodevelopment. MATERIALS AND METHODS:
      Ethical approval for this prospective study was given by the institutional review
      board, and informed parental consent was obtained. An unselected cohort of 110
      preterm infants (gestational age, < 32 weeks) was imaged around or after TEA.
      Clinical follow-up was performed at a corrected age of 2 years and consisted of a
      neurologic examination and a mental and developmental assessment (Bayley Scales
      of Infant Development). Univariate analyses and logistic and linear regression
      were performed to examine the relationships between variables. RESULTS: DEHSI was
      found in 58 of 65 (89%) infants imaged around TEA. DEHSI was never detected in
      infants imaged after postmenstrual age of 50 weeks and showed no association with
      neurodevelopmental outcome. Punctate WM lesions and ventricular dilatation were
      significantly associated with mental (P = .02 for punctate WM lesions) and
      psychomotor developmental delay (P < .001 and P = .03, respectively), motor delay
      (P = .002 and P = .02, respectively), and cerebral palsy (P = .01 and P = .03,
      respectively). CONCLUSION: Because of its high incidence in preterm infants
      around TEA, its absence after a postmenstrual age of 50 weeks, and its
      association with normal neurologic outcome at a corrected age of 2 years, DEHSI
      should not be considered part of the spectrum of WM injury, but rather a
      prematurity-related developmental phenomenon.
CI  - (c) RSNA, 2011.
FAU - de Bruine, Francisca T
AU  - de Bruine FT
AD  - Department of Radiology and Pediatrics, Subdivision of Neonatology, Leiden
      University Medical Center, Albinusdreef 2, PO Box 9600, 2300 RC, Leiden, the
      Netherlands.
FAU - van den Berg-Huysmans, Annette A
AU  - van den Berg-Huysmans AA
FAU - Leijser, Lara M
AU  - Leijser LM
FAU - Rijken, Monique
AU  - Rijken M
FAU - Steggerda, Sylke J
AU  - Steggerda SJ
FAU - van der Grond, Jeroen
AU  - van der Grond J
FAU - van Wezel-Meijler, Gerda
AU  - van Wezel-Meijler G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111026
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Cerebral Ventricles/growth & development/pathology
MH  - Chi-Square Distribution
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - *Infant, Premature
MH  - Leukomalacia, Periventricular/*pathology
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Nerve Fibers, Myelinated/pathology
MH  - Prospective Studies
MH  - Regression Analysis
EDAT- 2011/10/28 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/10/28 06:00
PHST- 2011/10/28 06:00 [entrez]
PHST- 2011/10/28 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - radiol.11110797 [pii]
AID - 10.1148/radiol.11110797 [doi]
PST - ppublish
SO  - Radiology. 2011 Dec;261(3):899-906. doi: 10.1148/radiol.11110797. Epub 2011 Oct
      26.


PMID- 22031708
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20220321
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 261
IP  - 3
DP  - 2011 Dec
TI  - Cortical diffusion-tensor imaging abnormalities in multiple sclerosis: a 3-year
      longitudinal study.
PG  - 891-8
LID - 10.1148/radiol.11110195 [doi]
AB  - PURPOSE: To evaluate whether diffusion-tensor imaging can be combined with double
      inversion recovery to improve the detection of structural changes occurring in
      the cortex of patients with multiple sclerosis (MS). MATERIALS AND METHODS: Once 
      local ethics committee approval and informed consent were obtained, 168 patients 
      with relapsing-remitting MS and 45 sex- and age-matched control subjects were
      included in a 3-year longitudinal study. Expanded Disability Status Scale (EDSS) 
      and magnetic resonance (MR) imaging examinations were performed at study entry
      and after 3 years. Number and volume of cortical lesions, T2 white matter lesion 
      volume (WMLV), and fractional anisotropy (FA) and mean diffusivity (MD) of
      normal-appearing gray matter (NAGM) and cortical lesions were analyzed.
      Between-group differences in terms of NAGM-FA and NAGM-MD were assessed with
      analysis of variance followed by Tukey test correction. RESULTS: At baseline,
      NAGM-FA was higher in patients (mean +/- standard deviation, 0.149 +/- 0.011)
      than in control subjects (0.125 +/- 0.008; P < .001) and higher in patients with 
      cortical lesions (0.154 +/- 0.011) than in those without (0.138 +/- 0.010; P <
      .001). Moreover, FA was higher in cortical lesions than in NAGM (P < .001). After
      3 years, NAGM-FA was unchanged in control subjects and increased in patients
      (0.154 +/- 0.012; P < .001), especially in patients with worsened EDSS score
      (0.170 +/- 0.011; P < .001). The same behavior was observed for NAGM-MD. At
      baseline, NAGM-FA significantly correlated with EDSS score (r = 0.75; P < .001)
      and cortical lesion volume (r = 0.850; P < .001). Multivariate analysis
      identified NAGM-FA (B = 0.654; P < .001) and T2 WMLV (B = 0.310; P < .001) as
      independent predictors of EDSS score, while NAGM-FA change (B = 0.523; P < .001) 
      and disease duration (B = 0.342; P < .001) were independent predictors of EDSS
      change. CONCLUSION: Compared with control subjects, patients with RRMS had an
      increase in FA of NAGM that strongly correlated with cortical lesion volume and
      clinical disability.
CI  - (c) RSNA, 2011.
FAU - Calabrese, Massimiliano
AU  - Calabrese M
AD  - Department of Neurosciences, Multiple Sclerosis Centre of Veneto Region-First
      Neurology Clinic, University Hospital of Padova, Via Giustiniani 5, 35128 Padua, 
      Italy. calabresem@hotmail.it
FAU - Rinaldi, Francesca
AU  - Rinaldi F
FAU - Seppi, Dario
AU  - Seppi D
FAU - Favaretto, Alice
AU  - Favaretto A
FAU - Squarcina, Letizia
AU  - Squarcina L
FAU - Mattisi, Irene
AU  - Mattisi I
FAU - Perini, Paola
AU  - Perini P
FAU - Bertoldo, Alessandra
AU  - Bertoldo A
FAU - Gallo, Paolo
AU  - Gallo P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111026
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Algorithms
MH  - Analysis of Variance
MH  - Anisotropy
MH  - Brain Mapping/methods
MH  - Case-Control Studies
MH  - Cerebral Cortex/*pathology
MH  - Diffusion Magnetic Resonance Imaging/*methods
MH  - Disability Evaluation
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Linear Models
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis, Relapsing-Remitting/*pathology
MH  - Prospective Studies
EDAT- 2011/10/28 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/10/28 06:00
PHST- 2011/10/28 06:00 [entrez]
PHST- 2011/10/28 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - radiol.11110195 [pii]
AID - 10.1148/radiol.11110195 [doi]
PST - ppublish
SO  - Radiology. 2011 Dec;261(3):891-8. doi: 10.1148/radiol.11110195. Epub 2011 Oct 26.


PMID- 22031539
OWN - NLM
STAT- MEDLINE
DCOM- 20120608
LR  - 20181201
IS  - 1552-681X (Electronic)
IS  - 0272-989X (Linking)
VI  - 32
IP  - 1
DP  - 2012 Jan-Feb
TI  - Health technology assessment implementation: the politics of ethics.
PG  - E13-9
LID - 10.1177/0272989X11418672 [doi]
AB  - Using a 2009 American debate on a federal public health recommendation on
      mammography screening for women under the age of 50 as a case study, it is argued
      that public acceptance of health technology assessment (HTA) depends on the
      ethical acceptability of its recommendations. At the same time, that
      acceptability cannot be separated from the politics and values of the health care
      system of which it is part. In the United States, those values display a sharp
      ideological split between a conservative individual-based ethic and a liberal
      community-oriented ethic. A clash of this kind cannot be solved by invocation of 
      ethical principles when it is those principles themselves that are in conflict.
      Inevitably HTA acceptance is threatened by this conflict as is the fate of health
      care reform.
FAU - Callahan, Daniel
AU  - Callahan D
AD  - The Hastings Center, Garrison, NY 10524, USA. callahand@thehastingscenter.org
LA  - eng
PT  - Journal Article
DEP - 20111026
PL  - United States
TA  - Med Decis Making
JT  - Medical decision making : an international journal of the Society for Medical
      Decision Making
JID - 8109073
SB  - IM
MH  - Breast Neoplasms/diagnostic imaging
MH  - Female
MH  - Humans
MH  - Mammography/statistics & numerical data
MH  - Middle Aged
MH  - *Politics
MH  - Technology Assessment, Biomedical/*ethics
MH  - United States
EDAT- 2011/10/28 06:00
MHDA- 2012/06/09 06:00
CRDT- 2011/10/28 06:00
PHST- 2011/10/28 06:00 [entrez]
PHST- 2011/10/28 06:00 [pubmed]
PHST- 2012/06/09 06:00 [medline]
AID - 0272989X11418672 [pii]
AID - 10.1177/0272989X11418672 [doi]
PST - ppublish
SO  - Med Decis Making. 2012 Jan-Feb;32(1):E13-9. doi: 10.1177/0272989X11418672. Epub
      2011 Oct 26.


PMID- 22031448
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 2157-3999 (Electronic)
IS  - 2157-3999 (Linking)
VI  - 3
DP  - 2011 Sep 21
TI  - Valuing lives: Allocating scarce medical resources during a public health
      emergency and the Americans with Disabilities Act (perspective).
PG  - RRN1271
LID - 10.1371/currents.RRN1271 [doi]
AB  - Public health emergencies from natural disasters, infection, and man-made threats
      can present ethically or legally challenging questions about who will receive
      scarce resources. Federal and state governments have offered little guidance on
      how to prioritize distribution of limited resources. Several allocation proposals
      have appeared in the medical literature, but components of the proposed
      approaches violate federal antidiscrimination laws and ethical principles about
      fair treatment. Further planning efforts are needed to develop practical
      allocation guidelines that comport with antidiscrimination laws and the moral
      commitment to equal access reflected in those laws.
FAU - Wolf, Leslie
AU  - Wolf L
AD  - Professor of Law, Georgia State University College of Law, Atlanta, GA.
FAU - Hensel, Wendy
AU  - Hensel W
LA  - eng
PT  - Journal Article
DEP - 20110921
PL  - United States
TA  - PLoS Curr
JT  - PLoS currents
JID - 101515638
PMC - PMC3199960
EDAT- 2011/10/28 06:00
MHDA- 2011/10/28 06:01
CRDT- 2011/10/28 06:00
PHST- 2011/09/21 00:00 [accepted]
PHST- 2011/10/28 06:00 [entrez]
PHST- 2011/10/28 06:00 [pubmed]
PHST- 2011/10/28 06:01 [medline]
AID - 10.1371/currents.RRN1271 [doi]
AID - k/-/-/2c8q7lnatgpgj/2 [pii]
PST - epublish
SO  - PLoS Curr. 2011 Sep 21;3:RRN1271. doi: 10.1371/currents.RRN1271.


PMID- 22031371
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20190911
IS  - 0080-6234 (Print)
IS  - 0080-6234 (Linking)
VI  - 45
IP  - 5
DP  - 2011 Oct
TI  - [The use of aromatherapy to improve self-esteem].
PG  - 1113-20
LID - S0080-62342011000500012 [pii]
AB  - The objectives of this study were to verify if inhaling rose and ylang-ylang
      essential oils has any effect on one's perception of self-esteem, and compare
      their efficiency. The study was approved by the University of Sao Paulo Hospital 
      Research Ethics Committee. Participants were 43 workers from the Sanitation
      Department and from the Materials and Sterilization Center, and the study took
      place from May to July 2009. Subjects were randomly assigned to one of three
      groups: two that received the essential oils and a third that received placebo
      (rose essence). The self-esteem evaluation was performed using a scale validated 
      in Brazil, which was applied before using the aromas, as well as 30 and 60 days
      after the use. Results showed that the sample consisted of 88.6% individuals with
      medium and high self-esteem, and that the essential oils did not make any
      significant changes to their perception of self-esteem.
FAU - Gnatta, Juliana Rizzo
AU  - Gnatta JR
AD  - Escola de Enfermagem, Universidade de Sao Paulo, Sao Paulo, SP, Brasil.
      juliana.gnatta@usp.br
FAU - Zotelli, Maria Filomena Mourao
AU  - Zotelli MF
FAU - Carmo, Dulce Regina Batista
AU  - Carmo DR
FAU - Lopes, Cristiane de Lion Botero Couto
AU  - Lopes Cde L
FAU - Rogenski, Noemi Marisa Brunet
AU  - Rogenski NM
FAU - da Silva, Maria Julia Paes
AU  - da Silva MJ
LA  - por
PT  - English Abstract
PT  - Journal Article
PT  - Randomized Controlled Trial
TT  - O uso da aromaterapia na melhora da autoestima.
PL  - Brazil
TA  - Rev Esc Enferm USP
JT  - Revista da Escola de Enfermagem da U S P
JID - 0242726
MH  - *Aromatherapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Self Concept
EDAT- 2011/10/28 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/10/28 06:00
PHST- 2010/05/02 00:00 [received]
PHST- 2010/12/20 00:00 [accepted]
PHST- 2011/10/28 06:00 [entrez]
PHST- 2011/10/28 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - S0080-62342011000500012 [pii]
AID - 10.1590/s0080-62342011000500012 [doi]
PST - ppublish
SO  - Rev Esc Enferm USP. 2011 Oct;45(5):1113-20. doi: 10.1590/s0080-62342011000500012.


PMID- 22031048
OWN - NLM
STAT- MEDLINE
DCOM- 20120130
LR  - 20191112
IS  - 1807-3107 (Electronic)
IS  - 1806-8324 (Linking)
VI  - 25
IP  - 5
DP  - 2011 Sep-Oct
TI  - Development of dental clinical research in Brazil: a few (new) ethical
      challenges.
PG  - 381-2
LID - S1806-83242011000500001 [pii]
FAU - Ramos, Dalton Luiz de Paula
AU  - Ramos DL
LA  - eng
PT  - Editorial
PL  - Brazil
TA  - Braz Oral Res
JT  - Brazilian oral research
JID - 101307187
SB  - IM
MH  - Brazil
MH  - Dental Research/*ethics/trends
MH  - Humans
EDAT- 2011/10/28 06:00
MHDA- 2012/01/31 06:00
CRDT- 2011/10/28 06:00
PHST- 2011/10/28 06:00 [entrez]
PHST- 2011/10/28 06:00 [pubmed]
PHST- 2012/01/31 06:00 [medline]
AID - S1806-83242011000500001 [pii]
AID - 10.1590/s1806-83242011000500001 [doi]
PST - ppublish
SO  - Braz Oral Res. 2011 Sep-Oct;25(5):381-2. doi: 10.1590/s1806-83242011000500001.


PMID- 22030885
OWN - NLM
STAT- MEDLINE
DCOM- 20120224
LR  - 20111027
IS  - 0124-0064 (Print)
IS  - 0124-0064 (Linking)
VI  - 13
IP  - 2
DP  - 2011 Apr
TI  - [Community pharmacies' professional image: causes and improvement strategies by
      applying qualitative research techniques].
PG  - 274-87
LID - S0124-00642011000200009 [pii]
AB  - OBJECTIVE: Ascertaining pharmacists' views related to factors explaining the lack
      of visibility of community pharmacies as being health facilities and proposing
      strategies for improving community pharmacy professional service accessibility
      using qualitative research techniques. METHODS: The nominal group technique (NGT)
      was used in two successive rounds using separate guidelines for factors and
      strategies. Framework analysis was then carried out. RESULTS: Thirty-four ideas
      related to "factors" and 32 related to "strategies" were obtained. Strategies
      were grouped into 14 topics, emphasising those prioritising patient-orientated
      professional services, ethical aspects and pharmacists' ongoing education.
      DISCUSSION: The techniques used led to identifying situations perceived by
      pharmacists which are not formally described in the literature. Raising awareness
      of professional services in community pharmacies implies agreeing on and
      developing strategies which should be based on joint participation by the
      pharmacists themselves, professional associations and universities.
FAU - Armando, Pedro D
AU  - Armando PD
AD  - Departamento de Farmacologia, Facultad de Ciencias Quimicas, Universidad Nacional
      de Cordoba, Argentina. parman@fc.unc.edu.ar
FAU - Vega, Elena M
AU  - Vega EM
FAU - Uema, Sonia A
AU  - Uema SA
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Imagen profesional de farmacias comunitarias: causas y estrategias de mejora
      aplicando tecnicas de investigacion cualitativa.
PL  - Colombia
TA  - Rev Salud Publica (Bogota)
JT  - Revista de salud publica (Bogota, Colombia)
JID - 100936348
SB  - IM
MH  - Argentina
MH  - *Community-Institutional Relations
MH  - Education, Pharmacy, Continuing
MH  - Focus Groups
MH  - Humans
MH  - *Pharmacies/economics/organization & administration
MH  - Public Opinion
MH  - Qualitative Research
MH  - Quality Improvement
MH  - Social Perception
EDAT- 2011/10/28 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/10/28 06:00
PHST- 2010/11/19 00:00 [received]
PHST- 2011/04/09 00:00 [accepted]
PHST- 2011/10/28 06:00 [entrez]
PHST- 2011/10/28 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - S0124-00642011000200009 [pii]
PST - ppublish
SO  - Rev Salud Publica (Bogota). 2011 Apr;13(2):274-87.


PMID- 22030758
OWN - NLM
STAT- MEDLINE
DCOM- 20120124
LR  - 20211203
IS  - 1938-808X (Electronic)
IS  - 1040-2446 (Linking)
VI  - 86
IP  - 12
DP  - 2011 Dec
TI  - Do extratherapeutic factors affect residents' decisions to prescribe medication
      for erectile dysfunction in ethically challenging scenarios?
PG  - 1525-31
LID - 10.1097/ACM.0b013e318235ac0d [doi]
AB  - PURPOSE: To examine residents' attitudes about prescribing medication for
      erectile dysfunction in ethically challenging scenarios. METHOD: In 2009, the
      authors surveyed internal medicine and family medicine residents at the
      University of California, San Diego, School of Medicine, asking them to indicate 
      how likely they would be to prescribe sildenafil citrate to patients in 10
      hypothetical scenarios. Eight scenarios had three nested variables: sexual
      identity, HIV status, and risk level. Two involved adulterous behavior; these
      were compared with two with monogamous behavior. The survey included four
      attitudinal questions about medical care and societal values. RESULTS: Of 128
      eligible residents, 81 (63%) responded. Respondents were more likely to prescribe
      sildenafil to hypothetical patients with low-risk behavior than to those with
      high-risk behavior (P < .001), more likely to prescribe sildenafil to patients
      who were HIV negative than to those who were HIV positive (P < .001), and more
      likely to prescribe sildenafil to monogamous patients than to patients in
      adulterous relationships (P < .001). Respondents who agreed that physicians are
      obliged to protect patients from their own risky behavior were likely to
      prescribe sildenafil in fewer scenarios than those who disagreed (P = .005).
      CONCLUSIONS: Extratherapeutic factors influenced residents' decisions about
      prescribing medication for erectile dysfunction. Paternalistic attitude was the
      only attitudinal factor that affected likelihood of prescribing sildenafil.
      Residency programs should help trainees understand the balance between respecting
      patients' rights and protecting society, and between personal values and
      professional obligations, as well as how biases may affect patient care.
FAU - Farber, Neil J
AU  - Farber NJ
AD  - University of California, San Diego, School of Medicine, La Jolla, California
      92037, USA. nfarber@ucsd.edu
FAU - Cederquist, Lynette
AU  - Cederquist L
FAU - Devereaux, Mary
AU  - Devereaux M
FAU - Brown, Ed
AU  - Brown E
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Acad Med
JT  - Academic medicine : journal of the Association of American Medical Colleges
JID - 8904605
RN  - 0 (Piperazines)
RN  - 0 (Purines)
RN  - 0 (Sulfones)
RN  - BW9B0ZE037 (Sildenafil Citrate)
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - California
MH  - Cross-Sectional Studies
MH  - Drug Utilization/statistics & numerical data
MH  - Erectile Dysfunction/diagnosis/*drug therapy
MH  - Ethnicity
MH  - Family Practice/education
MH  - Female
MH  - HIV Infections/diagnosis
MH  - Humans
MH  - Internal Medicine/education
MH  - *Internship and Residency
MH  - Male
MH  - Piperazines/*administration & dosage
MH  - Purines/administration & dosage
MH  - Risk Assessment
MH  - Sildenafil Citrate
MH  - Sulfones/*administration & dosage
MH  - Surveys and Questionnaires
EDAT- 2011/10/28 06:00
MHDA- 2012/01/25 06:00
CRDT- 2011/10/28 06:00
PHST- 2011/10/28 06:00 [entrez]
PHST- 2011/10/28 06:00 [pubmed]
PHST- 2012/01/25 06:00 [medline]
AID - 10.1097/ACM.0b013e318235ac0d [doi]
PST - ppublish
SO  - Acad Med. 2011 Dec;86(12):1525-31. doi: 10.1097/ACM.0b013e318235ac0d.


PMID- 22030533
OWN - NLM
STAT- MEDLINE
DCOM- 20111216
LR  - 20210106
IS  - 1529-4242 (Electronic)
IS  - 0032-1052 (Linking)
VI  - 128
IP  - 5
DP  - 2011 Nov
TI  - "Informed consent" does not inform the readers: complying with the journal's
      ethical standards and the declaration of Helsinki.
PG  - 577e-578e
LID - 10.1097/PRS.0b013e31822b6477 [doi]
FAU - Freshwater, M Felix
AU  - Freshwater MF
AD  - University of Miami School of Medicine, 9100 South Dadeland Boulevard, Suite 502,
      Miami, Fla. 33156-7815, mfelix.freshwater@gmail.com.
LA  - eng
PT  - Letter
PT  - Comment
PL  - United States
TA  - Plast Reconstr Surg
JT  - Plastic and reconstructive surgery
JID - 1306050
RN  - 0 (Biocompatible Materials)
SB  - IM
CON - Plast Reconstr Surg. 2011 Mar;127(3):1191-8. PMID: 21088646
MH  - *Biocompatible Materials
MH  - Erythema/*diagnosis
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted/*methods
MH  - Male
MH  - Skin/*pathology
MH  - Suture Techniques/*instrumentation
MH  - *Sutures
MH  - *Wound Healing
EDAT- 2011/10/28 06:00
MHDA- 2011/12/17 06:00
CRDT- 2011/10/28 06:00
PHST- 2011/10/28 06:00 [entrez]
PHST- 2011/10/28 06:00 [pubmed]
PHST- 2011/12/17 06:00 [medline]
AID - 10.1097/PRS.0b013e31822b6477 [doi]
AID - 00006534-201111000-00058 [pii]
PST - ppublish
SO  - Plast Reconstr Surg. 2011 Nov;128(5):577e-578e. doi:
      10.1097/PRS.0b013e31822b6477.


PMID- 22030511
OWN - NLM
STAT- MEDLINE
DCOM- 20111216
LR  - 20210106
IS  - 1529-4242 (Electronic)
IS  - 0032-1052 (Linking)
VI  - 128
IP  - 5
DP  - 2011 Nov
TI  - A position paper in support of hand transplantation in the blind.
PG  - 510e-515e
LID - 10.1097/PRS.0b013e31822b62e7 [doi]
AB  - Blind upper extremity amputees have historically been excluded from consideration
      for hand allotransplantation. Although no formal position statement regarding
      their exclusion has been published to date, functional, rehabilitative, and
      ethical concerns related to blind amputee candidacy for hand transplantation may 
      be inferred. The authors provide a summary of these reservations and a
      counterargument to their assumptions, drawing on outcomes measures reported for
      hand transplantations completed to date. The authors therefore provide a
      rationale for the inclusion of blind amputees in hand transplantation protocols
      in the future.
FAU - Carty, Matthew J
AU  - Carty MJ
AD  - Boston, Mass. From the Division of Plastic Surgery, Brigham and Women's
      Hospital/Faulkner Hospital, and the Department of Medicine, Brigham and Women's
      Hospital.
FAU - Bueno, Ericka
AU  - Bueno E
FAU - Lehmann, Lisa S
AU  - Lehmann LS
FAU - Pomahac, Bohdan
AU  - Pomahac B
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
PL  - United States
TA  - Plast Reconstr Surg
JT  - Plastic and reconstructive surgery
JID - 1306050
SB  - IM
CIN - Plast Reconstr Surg. 2011 Nov;128(5):516e-517e. PMID: 22030512
MH  - Amputation, Traumatic/*surgery
MH  - Amputees/statistics & numerical data
MH  - Attitude of Health Personnel
MH  - Blindness/*epidemiology
MH  - Comorbidity
MH  - Female
MH  - *Hand Transplantation
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Needs Assessment
MH  - Patient Selection
MH  - Practice Patterns, Physicians'/standards/trends
MH  - Risk Factors
MH  - Societies, Medical
MH  - Transplantation/ethics/methods/*statistics & numerical data
MH  - Transplantation, Homologous
MH  - United States/epidemiology
EDAT- 2011/10/28 06:00
MHDA- 2011/12/17 06:00
CRDT- 2011/10/28 06:00
PHST- 2011/10/28 06:00 [entrez]
PHST- 2011/10/28 06:00 [pubmed]
PHST- 2011/12/17 06:00 [medline]
AID - 10.1097/PRS.0b013e31822b62e7 [doi]
AID - 00006534-201111000-00028 [pii]
PST - ppublish
SO  - Plast Reconstr Surg. 2011 Nov;128(5):510e-515e. doi:
      10.1097/PRS.0b013e31822b62e7.


PMID- 22030419
OWN - NLM
STAT- MEDLINE
DCOM- 20120119
LR  - 20190902
IS  - 0317-1671 (Print)
IS  - 0317-1671 (Linking)
VI  - 38
IP  - 6
DP  - 2011 Nov
TI  - Neuroscience in Nazi Europe part II: resistance against the third reich.
PG  - 826-38
AB  - Previously, I mentioned that not all neuroscientists collaborated with the Nazis,
      who from 1933 to 1945 tried to eliminate neurologic and psychiatric disease from 
      the gene pool. Oskar and Cecile Vogt openly resisted and courageously protested
      against the Nazi regime and its policies, and have been discussed previously in
      the neurology literature. Here I discuss Alexander Mitscherlich, Haakon Saethre, 
      Walther Spielmeyer, Jules Tinel, and Johannes Pompe. Other neuroscientists had
      ambivalent roles, including Hans Creutzfeldt, who has been discussed previously. 
      Here, I discuss Max Nonne, Karl Bonhoeffer, and Oswald Bumke. The neuroscientists
      who resisted had different backgrounds and motivations that likely influenced
      their behavior, but this group undoubtedly saved lives of colleagues, friends,
      and patients, or at least prevented forced sterilizations. By recognizing and
      understanding the actions of these heroes of neuroscience, we pay homage and
      realize how ethics and morals do not need to be compromised even in dark times.
FAU - Zeidman, Lawrence A
AU  - Zeidman LA
AD  - Department of Neurology and Rehabilitation, Neuropsychiatric Institute,
      University of Illinois at Chicago, Illinois 60612-7330, USA.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Portrait
PT  - Review
PL  - England
TA  - Can J Neurol Sci
JT  - The Canadian journal of neurological sciences. Le journal canadien des sciences
      neurologiques
JID - 0415227
SB  - IM
CIN - Can J Neurol Sci. 2011 Nov;38(6):808-9. PMID: 22030416
MH  - Europe
MH  - History, 19th Century
MH  - History, 20th Century
MH  - Humans
MH  - National Socialism/*history
MH  - Neurology/*history
MH  - Neurosciences/*history
EDAT- 2011/10/28 06:00
MHDA- 2012/01/20 06:00
CRDT- 2011/10/28 06:00
PHST- 2011/10/28 06:00 [entrez]
PHST- 2011/10/28 06:00 [pubmed]
PHST- 2012/01/20 06:00 [medline]
AID - V0064388303K8754 [pii]
AID - 10.1017/s0317167100012397 [doi]
PST - ppublish
SO  - Can J Neurol Sci. 2011 Nov;38(6):826-38. doi: 10.1017/s0317167100012397.


PMID- 22030319
OWN - NLM
STAT- MEDLINE
DCOM- 20120208
LR  - 20180821
IS  - 1476-5616 (Electronic)
IS  - 0033-3506 (Linking)
VI  - 125
IP  - 12
DP  - 2011 Dec
TI  - Improving cancer treatment by addressing legislative and regulatory issues.
PG  - 876-881
LID - S0033-3506(11)00111-9 [pii]
LID - 10.1016/j.puhe.2011.03.016 [doi]
AB  - OBJECTIVES: To explore legislative and legal barriers to improving cancer
      treatment. METHODS: The advocacy agenda of Cancer Council Australia was examined 
      for key issues, and examples drawn from Australian law were presented at a
      conference entitled 'Legislate, regulate and litigate: legal perspectives on
      cancer prevention and treatment' at the University of Sydney. RESULTS: The
      introduction of electronic medical records and linkage of data sets from
      registries can produce very useful public health information, but could be a
      threat to individual privacy. The balance between these must underpin legislation
      and regulation. The new drug approval process must keep pace with developments
      such as targeted therapies, where tests to identify the presence of the target
      must also be approved simultaneously. The regulation of complementary and
      alternative medicines in cancer is challenging given their widespread use. In
      cancer research, it is vital that the important ethics and governance review
      process does not become a barrier to the ability to complete research in a
      reasonable time frame. A specific issue for future treatments and diagnostic
      tests that are to be targeted at genes and their products is to clarify gene
      patenting laws so that invention is rewarded, not mere discovery. The nature of
      the workforce will need to change to meet the treatment needs of an increasing
      incidence of cancer in an aging population, but regulation will need to ensure
      the maintenance of safety and quality standards. CONCLUSION: The flexibility of
      legislation and regulation to meet a rapidly changing environment is key to
      ensuring the timely adoption of new cancer treatments to improve cancer outcomes.
CI  - Copyright (c) 2011. Published by Elsevier Ltd.. All rights reserved.
FAU - Olver, I
AU  - Olver I
AD  - Cancer Council Australia, GPO Box 4708, Sydney, New South Wales 2001, Australia. 
      Electronic address: ian.olver@cancer.org.au.
LA  - eng
PT  - Journal Article
DEP - 20111024
PL  - Netherlands
TA  - Public Health
JT  - Public health
JID - 0376507
SB  - IM
MH  - Australia
MH  - Biomedical Research/legislation & jurisprudence
MH  - Diagnostic Tests, Routine
MH  - Drug Approval
MH  - Drug Therapy
MH  - Electronic Health Records
MH  - Humans
MH  - Legislation as Topic
MH  - Neoplasms/*therapy
MH  - *Policy Making
MH  - Public Policy/*legislation & jurisprudence
MH  - *Quality of Health Care
MH  - Registries
EDAT- 2011/10/28 06:00
MHDA- 2012/02/09 06:00
CRDT- 2011/10/28 06:00
PHST- 2010/10/25 00:00 [received]
PHST- 2011/02/19 00:00 [revised]
PHST- 2011/03/30 00:00 [accepted]
PHST- 2011/10/28 06:00 [entrez]
PHST- 2011/10/28 06:00 [pubmed]
PHST- 2012/02/09 06:00 [medline]
AID - S0033-3506(11)00111-9 [pii]
AID - 10.1016/j.puhe.2011.03.016 [doi]
PST - ppublish
SO  - Public Health. 2011 Dec;125(12):876-881. doi: 10.1016/j.puhe.2011.03.016. Epub
      2011 Oct 24.


PMID- 22030070
OWN - NLM
STAT- MEDLINE
DCOM- 20111227
LR  - 20151119
IS  - 1878-5921 (Electronic)
IS  - 0895-4356 (Linking)
VI  - 64
IP  - 12
DP  - 2011 Dec
TI  - STrengthening the Reporting of OBservational studies in Epidemiology--Molecular
      Epidemiology STROBE-ME: an extension of the STROBE statement.
PG  - 1350-63
LID - 10.1016/j.jclinepi.2011.07.010 [doi]
AB  - Advances in laboratory techniques have led to a rapidly increasing use of
      biomarkers in epidemiological studies. Biomarkers of internal dose, early
      biological change susceptibility and clinical outcomes are used as proxies for
      investigating the interactions between external and/or endogenous agents and body
      components or processes. The need for improved reporting of scientific research
      led to influential statements of recommendations such as the STrengthening
      Reporting of OBservational studies in Epidemiology (STROBE) statement. The STROBE
      initiative established in 2004 aimed to provide guidance on how to report
      observational research. Its guidelines provide a user-friendly checklist of 22
      items to be reported in epidemiological studies, with items specific to the three
      main study designs: cohort studies, case-control studies and cross-sectional
      studies. The present STrengthening the Reporting of OBservational studies in
      Epidemiology -Molecular Epidemiology (STROBE-ME) initiative builds on the STROBE 
      statement implementing 9 existing items of STROBE and providing 17 additional
      items to the 22 items of STROBE checklist. The additions relate to the use of
      biomarkers in epidemiological studies, concerning collection, handling and
      storage of biological samples; laboratory methods, validity and reliability of
      biomarkers; specificities of study design; and ethical considerations. The
      STROBE-ME recommendations are intended to complement the STROBE recommendations.
CI  - Copyright (c) 2011 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Gallo, Valentina
AU  - Gallo V
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Imperial
      College London, London, UK. v.gallo@imperial.ac.uk
FAU - Egger, Matthias
AU  - Egger M
FAU - McCormack, Valerie
AU  - McCormack V
FAU - Farmer, Peter B
AU  - Farmer PB
FAU - Ioannidis, John P A
AU  - Ioannidis JP
FAU - Kirsch-Volders, Micheline
AU  - Kirsch-Volders M
FAU - Matullo, Giuseppe
AU  - Matullo G
FAU - Phillips, David H
AU  - Phillips DH
FAU - Schoket, Bernadette
AU  - Schoket B
FAU - Stromberg, Ulf
AU  - Stromberg U
FAU - Vermeulen, Roel
AU  - Vermeulen R
FAU - Wild, Christopher
AU  - Wild C
FAU - Porta, Miquel
AU  - Porta M
FAU - Vineis, Paolo
AU  - Vineis P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Epidemiol
JT  - Journal of clinical epidemiology
JID - 8801383
RN  - 0 (Biomarkers)
SB  - IM
CIN - J Clin Epidemiol. 2013 Jan;66(1):113. PMID: 22742917
CIN - J Clin Epidemiol. 2013 Jan;66(1):1-2. PMID: 23177888
EIN - J Clin Epidemiol. 2012 Jul;65(7):813
MH  - *Biomarkers
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - *Epidemiologic Studies
MH  - *Evidence-Based Medicine
MH  - Humans
MH  - *Molecular Epidemiology
MH  - Observation
MH  - *Practice Guidelines as Topic
MH  - Publishing/standards
MH  - Reproducibility of Results
MH  - Research Design
EDAT- 2011/10/28 06:00
MHDA- 2011/12/28 06:00
CRDT- 2011/10/28 06:00
PHST- 2010/10/25 00:00 [received]
PHST- 2011/05/17 00:00 [revised]
PHST- 2011/05/24 00:00 [accepted]
PHST- 2011/10/28 06:00 [entrez]
PHST- 2011/10/28 06:00 [pubmed]
PHST- 2011/12/28 06:00 [medline]
AID - S0895-4356(11)00246-0 [pii]
AID - 10.1016/j.jclinepi.2011.07.010 [doi]
PST - ppublish
SO  - J Clin Epidemiol. 2011 Dec;64(12):1350-63. doi: 10.1016/j.jclinepi.2011.07.010.


PMID- 22029945
OWN - NLM
STAT- MEDLINE
DCOM- 20120418
LR  - 20151119
IS  - 1096-0260 (Electronic)
IS  - 0091-7435 (Linking)
VI  - 53
IP  - 6
DP  - 2011 Dec
TI  - STrengthening the Reporting of OBservational studies in Epidemiology - Molecular 
      Epidemiology (STROBE-ME): an extension of the STROBE statement.
PG  - 377-87
LID - 10.1016/j.ypmed.2011.08.007 [doi]
AB  - Advances in laboratory techniques have led to a rapidly increasing use of
      biomarkers in epidemiological studies. Biomarkers of internal dose, early
      biological change, susceptibility and clinical outcomes are used as proxies for
      investigating the interactions between external and/or endogenous agents and the 
      body components or processes. The need for improved reporting of scientific
      research led to influential statements of recommendations such as the
      STrenghtening Reporting of Observational studies in Epidemiology (STROBE)
      statement. The STROBE initiative established in 2004 aimed to provide guidance on
      how to report observational research. Its guidelines provide a user-friendly
      checklist of 22 items to be reported in epidemiological studies, with items
      specific to the three main study designs: cohort studies, case-control studies
      and cross-sectional studies. The present STrengthening the Reporting of
      OBservational studies in Epidemiology - Molecular Epidemiology (STROBE-ME)
      initiative builds on the STROBE Statement implementing 9 existing items of STROBE
      and providing 17 additional items to the 22 items of STROBE checklist. The
      additions relate to the use of biomarkers in epidemiological studies, concerning 
      collection, handling and storage of biological samples; laboratory methods,
      validity and reliability of biomarkers; specificities of study design; and
      ethical considerations. The STROBE-ME recommendations are intended to complement 
      the STROBE recommendations.
CI  - Copyright (c) 2011 The American Health Foundation. Published by Elsevier Inc. All
      rights reserved.
FAU - Gallo, Valentina
AU  - Gallo V
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Imperial
      College London, London, UK. v.gallo@imperial.ac.uk
FAU - Egger, Matthias
AU  - Egger M
FAU - McCormack, Valerie
AU  - McCormack V
FAU - Farmer, Peter B
AU  - Farmer PB
FAU - Ioannidis, John P A
AU  - Ioannidis JP
FAU - Kirsch-Volders, Micheline
AU  - Kirsch-Volders M
FAU - Matullo, Giuseppe
AU  - Matullo G
FAU - Phillips, David H
AU  - Phillips DH
FAU - Schoket, Bernadette
AU  - Schoket B
FAU - Stromberg, Ulf
AU  - Stromberg U
FAU - Vermeulen, Roel
AU  - Vermeulen R
FAU - Wild, Christopher
AU  - Wild C
FAU - Porta, Miquel
AU  - Porta M
FAU - Vineis, Paolo
AU  - Vineis P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111024
PL  - United States
TA  - Prev Med
JT  - Preventive medicine
JID - 0322116
RN  - 0 (Biomarkers)
SB  - IM
EIN - Prev Med. 2012 May;54(5):367
MH  - *Biomarkers
MH  - Checklist
MH  - *Epidemiologic Studies
MH  - Humans
MH  - *Molecular Epidemiology
MH  - Observation/methods
EDAT- 2011/10/28 06:00
MHDA- 2012/04/19 06:00
CRDT- 2011/10/28 06:00
PHST- 2011/05/20 00:00 [received]
PHST- 2011/07/14 00:00 [revised]
PHST- 2011/08/07 00:00 [accepted]
PHST- 2011/10/28 06:00 [entrez]
PHST- 2011/10/28 06:00 [pubmed]
PHST- 2012/04/19 06:00 [medline]
AID - S0091-7435(11)00296-9 [pii]
AID - 10.1016/j.ypmed.2011.08.007 [doi]
PST - ppublish
SO  - Prev Med. 2011 Dec;53(6):377-87. doi: 10.1016/j.ypmed.2011.08.007. Epub 2011 Oct 
      24.


PMID- 22029813
OWN - NLM
STAT- MEDLINE
DCOM- 20120214
LR  - 20211203
IS  - 1752-8062 (Electronic)
IS  - 1752-8054 (Linking)
VI  - 4
IP  - 5
DP  - 2011 Oct
TI  - Moving from the laboratory bench to patients' bedside: considerations for
      effective therapy with stem cells.
PG  - 380-6
LID - 10.1111/j.1752-8062.2011.00283.x [doi]
AB  - Although stem cell therapy is not a new field, the field was limited to
      transplantation of hematopoietic stem cells. Such transplantation has provided
      invaluable information for the emerging field with new stem cells. Mesenchymal
      stem cells (MSCs) are an attractive source for therapy; reduced ethical concern, 
      ease in expansion, as off-the-shelf stem cells. MSCs exert immune suppressive
      properties, providing them with the potential for immune suppressive therapy such
      as autoimmunity, asthma, allergic rhinitis and graft versus host disease. In
      addition, MSCs, as well as other stem cells, can be applied for bone and
      cartilage repair, cardiovascular disease, and neural repair/protection. The data 
      thus far with MSCs are mixed. This review discusses the immune-enhancing
      properties of MSCs to explain the possible confounds of inflammatory
      microenvironment in the MSCs therapy. Although this review focuses on MSCs, the
      information can be extrapolated to other stem cells. The review summarizes the
      biology of MSCs, including multilineage differentiation potential,
      transdifferentiation capability, and immunological effects. We emphasize the key 
      concepts that may predict the use of these cells in medicine, namely, the
      application of these cells from the bench to the bedside. Prospects on
      immunotherapy, neuroregeneration, and cardiovascular repair are used as examples 
      of tissue repair.
CI  - (c) 2011 Wiley Periodicals, Inc.
FAU - Sherman, Lauren S
AU  - Sherman LS
AD  - University of Medicine and Dentistry of New Jersey-New Jersey Medical School,
      Newark, New Jersey, USA.
FAU - Munoz, Jessian
AU  - Munoz J
FAU - Patel, Shyam A
AU  - Patel SA
FAU - Dave, Meneka A
AU  - Dave MA
FAU - Paige, Ilani
AU  - Paige I
FAU - Rameshwar, Pranela
AU  - Rameshwar P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Clin Transl Sci
JT  - Clinical and translational science
JID - 101474067
RN  - 0 (Inflammation Mediators)
SB  - IM
MH  - Cellular Microenvironment
MH  - Humans
MH  - Inflammation Mediators/metabolism
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Mesenchymal Stem Cells/*cytology/immunology
MH  - Translational Research, Biomedical/*methods
MH  - Wound Healing
PMC - PMC5439898
EDAT- 2011/10/28 06:00
MHDA- 2012/02/15 06:00
CRDT- 2011/10/28 06:00
PHST- 2011/10/28 06:00 [entrez]
PHST- 2011/10/28 06:00 [pubmed]
PHST- 2012/02/15 06:00 [medline]
AID - 10.1111/j.1752-8062.2011.00283.x [doi]
PST - ppublish
SO  - Clin Transl Sci. 2011 Oct;4(5):380-6. doi: 10.1111/j.1752-8062.2011.00283.x.


PMID- 22028679
OWN - NLM
STAT- MEDLINE
DCOM- 20120217
LR  - 20211020
IS  - 1654-9880 (Electronic)
IS  - 1654-9880 (Linking)
VI  - 4
DP  - 2011
TI  - Screening of women for intimate partner violence: a pilot intervention at an
      outpatient department in Tanzania.
PG  - 7288
LID - 10.3402/gha.v4i0.7288 [doi]
AB  - UNLABELLED: Intimate partner violence (IPV) is a public health problem in
      Tanzania with limited health care interventions. OBJECTIVES: To study the
      feasibility of using an abuse screening tool for women attending an outpatient
      department, and describe how health care workers perceived its benefits and
      challenges. METHODS: Prior to screening, 39 health care workers attended training
      on gender-based violence and the suggested screening procedures. Seven health
      care workers were arranged to implement screening in 3 weeks, during March-April 
      2010. For screening evaluation, health care workers were observed for their
      interaction with clients. Thereafter, focus group discussions (FGDs) were
      conducted with 21 health care workers among those who had participated in the
      training and screening. Five health care workers wrote narratives. Women's
      responses to screening questions were analyzed with descriptive statistics,
      whereas qualitative content analysis guided analysis of qualitative data.
      RESULTS: Of the 102 women screened, 78% had experienced emotional, physical, or
      sexual violence. Among them, 62% had experienced IPV, while 22% were subjected to
      violence by a relative, and 9.2% by a work mate. Two-thirds (64%) had been abused
      more than once; 14% several times. Almost one-quarter (23%) had experienced
      sexual violence. Six of the health care workers interacted well with clients but 
      three had difficulties to follow counseling guidelines. FGDs and narratives
      generated three categories Just asking feels good implied a blessing of the tool;
      what next? indicated ethical dilemmas; and fear of becoming a 'women hospital'
      only indicated a concern that abused men would be neglected. CONCLUSIONS:
      Screening for IPV is feasible. Overall, the health care workers perceived the
      tool to be advantageous. Training on gender-based violence and adjustment of the 
      tool to suit local structures are important. Further studies are needed to
      explore the implications of including abuse against men and children in future
      screening.
CI  - (c) 2011 Rose M. Laisser et al.
FAU - Laisser, Rose M
AU  - Laisser RM
AD  - Institute of Allied Health Sciences Midwifery School, Muhimbili University of
      Health and Allied Sciences (MUHAS), Dar es Salaam, Tanzania. rlaisser@hotmail.com
FAU - Nystrom, Lennarth
AU  - Nystrom L
FAU - Lindmark, Gunilla
AU  - Lindmark G
FAU - Lugina, Helen I
AU  - Lugina HI
FAU - Emmelin, Maria
AU  - Emmelin M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111021
PL  - United States
TA  - Glob Health Action
JT  - Global health action
JID - 101496665
SB  - IM
MH  - *Ambulatory Care Facilities
MH  - *Domestic Violence/psychology/statistics & numerical data
MH  - Feasibility Studies
MH  - Female
MH  - Focus Groups
MH  - Health Personnel
MH  - Humans
MH  - Male
MH  - *Mass Screening
MH  - Pilot Projects
MH  - *Professional-Patient Relations
MH  - *Sexual Partners
PMC - PMC3200434
OTO - NOTNLM
OT  - Tanzania
OT  - abuse screening
OT  - health care workers
OT  - intimate partner violence
EDAT- 2011/10/27 06:00
MHDA- 2012/02/18 06:00
CRDT- 2011/10/27 06:00
PHST- 2011/05/15 00:00 [received]
PHST- 2011/09/30 00:00 [revised]
PHST- 2011/09/30 00:00 [accepted]
PHST- 2011/10/27 06:00 [entrez]
PHST- 2011/10/27 06:00 [pubmed]
PHST- 2012/02/18 06:00 [medline]
AID - 10.3402/gha.v4i0.7288 [doi]
AID - GHA-4-7288 [pii]
PST - ppublish
SO  - Glob Health Action. 2011;4:7288. doi: 10.3402/gha.v4i0.7288. Epub 2011 Oct 21.


PMID- 22028504
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 0975-1580 (Electronic)
IS  - 0972-124X (Linking)
VI  - 15
IP  - 3
DP  - 2011 Jul
TI  - Where will the stem cells lead us? Prospects for dentistry in the 21 century.
PG  - 199-204
LID - 10.4103/0972-124X.85660 [doi]
AB  - It is dentists' dream to achieve bone repair with predictability, but without
      donor site morbidity as well as reconstruction of injured or pathologically
      damaged complex dental structures, however, this will no longer be a dream as
      these are being made into a reality using stem cell science. Stem cell science is
      clearly an intriguing and promising area of science. Stem cells have been
      isolated from a variety of embryonic and adult tissues. Dental stem cells are
      multipotent mesenchymal stem cells (MSCs) brought new enthusiasm among the
      researchers because of their easy accessibility, high quality and they don't pose
      the same ethical concerns and controversy in comparison with embryonic stem
      cells. This review article provides brief insights about stem cell basics, the
      state of art in human dental stem cell research and its possible impact on future
      dentistry. Even though most of these modalities are still in infancy, it is
      evident that the 21(st) century dentist is going to play a critical role in the
      field of medicine. The aim of this article is to bring awareness among the
      dentists about the huge potential associated with the use of stem cells in a
      clinical setting, as well as proper understanding of related problems.
FAU - Sreenivas, S Durga
AU  - Sreenivas SD
AD  - Department of Oral and Maxillofacial Surgery, MNR Dental College and Hospital,
      Sangareddy, Andhra Pradesh, India.
FAU - Rao, Akula Sreenivasa
AU  - Rao AS
FAU - Satyavani, S Sri
AU  - Satyavani SS
FAU - Reddy, Bavigadda Harish
AU  - Reddy BH
FAU - Vasudevan, Sanjay
AU  - Vasudevan S
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Indian Soc Periodontol
JT  - Journal of Indian Society of Periodontology
JID - 101499342
PMC - PMC3200012
OTO - NOTNLM
OT  - Mesenchymal stem cells
OT  - stem cells
OT  - tooth engineering
EDAT- 2011/10/27 06:00
MHDA- 2011/10/27 06:01
CRDT- 2011/10/27 06:00
PHST- 2011/04/15 00:00 [received]
PHST- 2011/09/03 00:00 [accepted]
PHST- 2011/10/27 06:00 [entrez]
PHST- 2011/10/27 06:00 [pubmed]
PHST- 2011/10/27 06:01 [medline]
AID - 10.4103/0972-124X.85660 [doi]
AID - JISP-15-199 [pii]
PST - ppublish
SO  - J Indian Soc Periodontol. 2011 Jul;15(3):199-204. doi: 10.4103/0972-124X.85660.


PMID- 22027842
OWN - NLM
STAT- MEDLINE
DCOM- 20120417
LR  - 20151119
IS  - 1464-3804 (Electronic)
IS  - 0267-8357 (Linking)
VI  - 27
IP  - 1
DP  - 2012 Jan
TI  - STrengthening the Reporting of OBservational studies in Epidemiology--Molecular
      Epidemiology (STROBE-ME): an extension of the STROBE statement.
PG  - 17-29
LID - 10.1093/mutage/ger039 [doi]
AB  - Advances in laboratory techniques have led to a rapidly increasing use of
      biomarkers in epidemiological studies. Biomarkers of internal dose, early
      biological change, susceptibility and clinical outcomes are used as proxies for
      investigating interactions between external and / or endogenous agents and body
      components or processes. The need for improved reporting of scientific research
      led to influential statements of recommendations such as the STrengthening
      Reporting of OBservational studies in Epidemiology (STROBE) statement. The STROBE
      initiative established in 2004 aimed to provide guidance on how to report
      observational research. Its guidelines provide a user-friendly checklist of 22
      items to be reported in epidemiological studies, with items specific to the three
      main study designs: cohort studies, case-control studies and cross-sectional
      studies. The present STrengthening the Reporting of OBservational studies in
      Epidemiology - Molecular Epidemiology (STROBE-ME) initiative builds on the STROBE
      statement implementing nine existing items of STROBE and providing 17 additional 
      items to the 22 items of STROBE checklist. The additions relate to the use of
      biomarkers in epidemiological studies, concerning collection, handling and
      storage of biological samples; laboratory methods, validity and reliability of
      biomarkers; specificities of study design; and ethical considerations. The
      STROBE-ME recommendations are intended to complement the STROBE recommendations.
FAU - Gallo, Valentina
AU  - Gallo V
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Imperial
      College London, London, UK. v.gallo@imperial.ac.uk
FAU - Egger, Matthias
AU  - Egger M
FAU - McCormack, Valerie
AU  - McCormack V
FAU - Farmer, Peter B
AU  - Farmer PB
FAU - Ioannidis, John P A
AU  - Ioannidis JP
FAU - Kirsch-Volders, Micheline
AU  - Kirsch-Volders M
FAU - Matullo, Giuseppe
AU  - Matullo G
FAU - Phillips, David H
AU  - Phillips DH
FAU - Schoket, Bernadette
AU  - Schoket B
FAU - Stromberg, Ulf
AU  - Stromberg U
FAU - Vermeulen, Roel
AU  - Vermeulen R
FAU - Wild, Christopher
AU  - Wild C
FAU - Porta, Miquel
AU  - Porta M
FAU - Vineis, Paolo
AU  - Vineis P
LA  - eng
PT  - Journal Article
DEP - 20111025
PL  - England
TA  - Mutagenesis
JT  - Mutagenesis
JID - 8707812
RN  - 0 (Biomarkers)
SB  - IM
EIN - Mutagenesis. 2012 May;27(3):383
MH  - Biomarkers/*blood
MH  - Case-Control Studies
MH  - Checklist
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - *Epidemiologic Research Design
MH  - Evidence-Based Medicine
MH  - *Guidelines as Topic
MH  - Humans
MH  - Molecular Epidemiology/*methods
MH  - Observation/methods
MH  - Reference Standards
MH  - Reproducibility of Results
MH  - Research Design
EDAT- 2011/10/27 06:00
MHDA- 2012/04/18 06:00
CRDT- 2011/10/27 06:00
PHST- 2011/10/27 06:00 [entrez]
PHST- 2011/10/27 06:00 [pubmed]
PHST- 2012/04/18 06:00 [medline]
AID - ger039 [pii]
AID - 10.1093/mutage/ger039 [doi]
PST - ppublish
SO  - Mutagenesis. 2012 Jan;27(1):17-29. doi: 10.1093/mutage/ger039. Epub 2011 Oct 25.


PMID- 22027814
OWN - NLM
STAT- MEDLINE
DCOM- 20120229
LR  - 20111110
IS  - 1473-5725 (Electronic)
IS  - 1359-5237 (Linking)
VI  - 16
IP  - 6
DP  - 2011 Dec
TI  - Accuracy assessment of a novel blood pressure measurement device in a South
      African adult population: Tensoval duo control.
PG  - 304-6
LID - 10.1097/MBP.0b013e32834db648 [doi]
AB  - OBJECTIVE: The Tensoval duo control device uses a novel combination of
      auscultatory and oscillometric technology to measure blood pressure. We assessed 
      the accuracy of this device in a South African adult population according to the 
      International Protocol of the European Society of Hypertension. METHODS: Ethical 
      approval was obtained and 33 participants were recruited from Kimberley Hospital 
      Complex (South Africa). Trained observers took sequential same arm blood pressure
      measurements from each participant, alternating between mercury sphygmomanometery
      and the device. RESULTS: The Tensoval duo control passed all the phases of the
      protocol and achieved a mean difference +/- SD of -3.2 +/- 7.2 and 2.0 +/- 6.0
      mmHg for systolic and diastolic pressures, respectively. CONCLUSION: This study
      confirms the accuracy and recommendation for clinical use of the Tensoval duo
      control device in adults. Accuracy in special patient groups is yet to be
      assessed, but this novel technology could be particularly valuable in those with 
      vascular disease.
FAU - de Greeff, Annemarie
AU  - de Greeff A
AD  - Women's Academic Health Centre, King's Health Partners, King's College London, St
      Thomas' Hospital, London SE1 7EH, UK. annemarie.de_greeff@kcl.ac.uk
FAU - Hezelgrave, Natasha
AU  - Hezelgrave N
FAU - Shennan, Andrew H
AU  - Shennan AH
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Blood Press Monit
JT  - Blood pressure monitoring
JID - 9606438
SB  - IM
MH  - Adult
MH  - Blood Pressure Determination/instrumentation/methods
MH  - *Blood Pressure Monitors
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oscillometry/*instrumentation/*methods
MH  - Sensitivity and Specificity
MH  - South Africa
EDAT- 2011/10/27 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/10/27 06:00
PHST- 2011/10/27 06:00 [entrez]
PHST- 2011/10/27 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - 10.1097/MBP.0b013e32834db648 [doi]
PST - ppublish
SO  - Blood Press Monit. 2011 Dec;16(6):304-6. doi: 10.1097/MBP.0b013e32834db648.


PMID- 22027646
OWN - NLM
STAT- MEDLINE
DCOM- 20120427
LR  - 20211020
IS  - 0949-2321 (Print)
IS  - 0949-2321 (Linking)
VI  - 16
IP  - 11
DP  - 2011 Nov 10
TI  - The influence of micronutrients on oral and general health.
PG  - 514-8
AB  - OBJECTIVE: The aim of the present clinical pilot study was to examine the
      influence of a combination of micronutrients on individuals with high stress
      experience. METHODS: 40 healthy students (28 female, 12 male) with a mean age of 
      27.1 +/- 3.0 years, experiencing high examination stress, were chosen. After
      approval of the ethics commission, one group of students (n = 19) took a
      combination of micronutrients (Orthomol vital m/f) for three months, whereas
      other students (n = 21) served as control group. All participants underwent at
      the beginning and at the end of the trial a dental examination, a determination
      of 10 periodontal pathogens, a salivary and a blood analysis. In addition, the
      participants filled in a questionnaire on nutrition, quality of life and degree
      of stress experienced during their final examinations. RESULTS: The evaluation of
      the results, obtained at the end of the trial period, showed that for all
      students a slight worsening of oral hygiene and an increased consumption of
      unhealthy food could be observed. The intake of the micronutrients led to a
      slight improvement of the degree of gingival inflammation in comparison to the
      control group. The blood analysis showed an increase in vitamin (vitamin C,
      vitamin E) and zinc concentrations, and a lower increase in CRP. In the male
      subjects, a decrease in the serum concentrations of triglycerides (p = 0.073) and
      LDL (p = 0.048) was observed. CONCLUSIONS: This pilot study shows that
      micronutrients, taken during periods of high stress experience, had a beneficial 
      effect on inflammatory processes and helped reduce the level of some of the
      plasma lipids in males, and thus can be recommended for supplementing the diet.
      However, additional studies with a higher number of subjects, also suffering from
      periodontal disease, are necessary to show the effect of a micronutrient
      supplementation more clearly.
FAU - Willershausen, Brita
AU  - Willershausen B
AD  - Department of Operative Dentistry, Johannes Gutenberg-University Mainz, Mainz,
      Germany. willersh@uni-mainz.de
FAU - Ross, A
AU  - Ross A
FAU - Forsch, M
AU  - Forsch M
FAU - Willershausen, I
AU  - Willershausen I
FAU - Mohaupt, Ph
AU  - Mohaupt P
FAU - Callaway, A
AU  - Callaway A
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - Eur J Med Res
JT  - European journal of medical research
JID - 9517857
RN  - 0 (Micronutrients)
SB  - IM
MH  - Adult
MH  - Blood Chemical Analysis
MH  - Female
MH  - Gingiva/drug effects/pathology
MH  - Humans
MH  - Inflammation/pathology
MH  - Male
MH  - Micronutrients/administration & dosage/*pharmacology
MH  - *Oral Health
MH  - Young Adult
PMC - PMC3351810
EDAT- 2011/10/27 06:00
MHDA- 2012/04/28 06:00
CRDT- 2011/10/27 06:00
PHST- 2011/10/27 06:00 [entrez]
PHST- 2011/10/27 06:00 [pubmed]
PHST- 2012/04/28 06:00 [medline]
AID - 10.1186/2047-783x-16-11-514 [doi]
PST - ppublish
SO  - Eur J Med Res. 2011 Nov 10;16(11):514-8. doi: 10.1186/2047-783x-16-11-514.


PMID- 22027164
OWN - NLM
STAT- MEDLINE
DCOM- 20111213
LR  - 20111026
IS  - 1603-6824 (Electronic)
IS  - 0041-5782 (Linking)
VI  - 173
IP  - 42
DP  - 2011 Oct 17
TI  - [Palliative care of patients with terminal obstructive pulmonary disease].
PG  - 2641-4
AB  - Terminal chronic obstructive pulmonary disease (COPD) and advanced cancer have
      similar prognosis and symptom burden. However, palliative care of patients with
      terminal COPD has been neglected in Denmark. We describe the symptoms of terminal
      COPD and suggest criteria for defining the palliative phase of the disease.
      Furthermore we discuss the prognostic and ethical challenges for patients, their 
      families and their caregivers. Finally, we summarize the current evidence for
      palliative treatment of dyspnoea and ways to evaluate response to treatment.
FAU - von Plessen, Christian
AU  - von Plessen C
AD  - Lunge- og infektionsmedicinsk Afdeling, Hillerod Hospital, Dyrehavevej 29, 3400
      Hillerod, Denmark. cple@hih.regionh.dk
FAU - Nielsen, Thyge L
AU  - Nielsen TL
FAU - Steffensen, Ida E
AU  - Steffensen IE
FAU - Larsen, Shuruk Al-Halwai
AU  - Larsen SA
FAU - Taudorf, Ebbe
AU  - Taudorf E
LA  - dan
PT  - English Abstract
PT  - Journal Article
TT  - Palliativ behandling af patienter med terminal kronisk obstruktiv lungesygdom.
PL  - Denmark
TA  - Ugeskr Laeger
JT  - Ugeskrift for laeger
JID - 0141730
SB  - IM
MH  - Caregivers/psychology
MH  - Denmark
MH  - Dyspnea/drug therapy/nursing/therapy
MH  - Humans
MH  - *Palliative Care/methods/organization & administration
MH  - Professional-Family Relations
MH  - Professional-Patient Relations
MH  - Prognosis
MH  - Pulmonary Disease, Chronic Obstructive/diagnosis/nursing/*therapy
MH  - *Terminal Care/methods/organization & administration
EDAT- 2011/10/27 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/10/27 06:00
PHST- 2011/10/27 06:00 [entrez]
PHST- 2011/10/27 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - VP60503 [pii]
PST - ppublish
SO  - Ugeskr Laeger. 2011 Oct 17;173(42):2641-4.


PMID- 22027059
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20111026
IS  - 1878-3570 (Electronic)
IS  - 0002-8223 (Linking)
VI  - 111
IP  - 11
DP  - 2011 Nov
TI  - Obtaining and using copyrighted research journal content--convenience vs ethics.
PG  - 1746-8
LID - 10.1016/j.jada.2011.09.029 [doi]
FAU - Ritter-Gooder, Paula K
AU  - Ritter-Gooder PK
AD  - Department of Nutrition and Health Sciences, University of Nebraska-Lincoln,
      Lincoln, NE, USA.
FAU - Lewis, Nancy M
AU  - Lewis NM
FAU - Delserone, Leslie M
AU  - Delserone LM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Diet Assoc
JT  - Journal of the American Dietetic Association
JID - 7503061
SB  - IM
MH  - Copyright/*ethics/*legislation & jurisprudence
MH  - Data Collection/methods
MH  - Dietetics/*ethics
MH  - Humans
MH  - *Periodicals as Topic
MH  - United States
EDAT- 2011/10/27 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/10/27 06:00
PHST- 2011/09/08 00:00 [received]
PHST- 2011/10/27 06:00 [entrez]
PHST- 2011/10/27 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0002-8223(11)01571-9 [pii]
AID - 10.1016/j.jada.2011.09.029 [doi]
PST - ppublish
SO  - J Am Diet Assoc. 2011 Nov;111(11):1746-8. doi: 10.1016/j.jada.2011.09.029.


PMID- 22026259
OWN - NLM
STAT- MEDLINE
DCOM- 20111220
LR  - 20111026
IS  - 0008-7335 (Print)
IS  - 0008-7335 (Linking)
VI  - 150
IP  - 7
DP  - 2011
TI  - [National Database of Genotypes--ethical and legal issues].
PG  - 372-5; discussion 376-7
AB  - National Database of Genotypes--ethical and legal issues The aim of the project
      National Database of Genotypes is to outline structure and rules for the database
      operation collecting information about genotypes of individual persons. The
      database should be used entirely for health care. Its purpose is to enable
      physicians to gain quick and easy access to the information about persons
      requiring specialized care due to their genetic constitution. In the future,
      another introduction of new genetic tests into the clinical practice can be
      expected thus the database of genotypes facilitates substantial financial savings
      by exclusion of duplicates of the expensive genetic testing. Ethical questions
      connected with the creating and functioning of such database concern mainly
      privacy protection, confidentiality of personal sensitive data, protection of
      database from misuse, consent with participation and public interests. Due to
      necessity of correct interpretation by qualified professional (= clinical
      geneticist), particular categorization of genetic data within the database is
      discussed. The function of proposed database has to be governed in concordance
      with the Czech legislation together with solving ethical problems.
FAU - Frankova, Vera
AU  - Frankova V
AD  - Univerzita Karlova v Praze, 1. lekarska fakulta, Ustav pro humanitni studia v
      lekarstvi a Ustav dadicnych metabolickych poruch. vera.frankova@gmail.com
FAU - Tesinova, Jolana
AU  - Tesinova J
FAU - Brdicka, Radim
AU  - Brdicka R
LA  - cze
PT  - English Abstract
PT  - Journal Article
TT  - Narodni databaze genotypu--eticke a pravni aspekty.
PL  - Czech Republic
TA  - Cas Lek Cesk
JT  - Casopis lekaru ceskych
JID - 0004743
SB  - IM
MH  - *Bioethical Issues
MH  - Czech Republic
MH  - Databases, Genetic/*ethics/*legislation & jurisprudence
MH  - Genetic Privacy/ethics/legislation & jurisprudence
MH  - *Genotype
MH  - Humans
EDAT- 2011/10/27 06:00
MHDA- 2011/12/21 06:00
CRDT- 2011/10/27 06:00
PHST- 2011/10/27 06:00 [entrez]
PHST- 2011/10/27 06:00 [pubmed]
PHST- 2011/12/21 06:00 [medline]
PST - ppublish
SO  - Cas Lek Cesk. 2011;150(7):372-5; discussion 376-7.


PMID- 22025875
OWN - NLM
STAT- MEDLINE
DCOM- 20120118
LR  - 20211020
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Linking)
VI  - 17
IP  - 34
DP  - 2011 Sep 14
TI  - Therapeutic application of stem cells in gastroenterology: an up-date.
PG  - 3870-80
LID - 10.3748/wjg.v17.i34.3870 [doi]
AB  - Adult stem cells represent the self-renewing progenitors of numerous body
      tissues, and they are currently classified according to their origin and
      differentiation ability. In recent years, the research on stem cells has expanded
      enormously and holds therapeutic promises for many patients suffering from
      currently disabling diseases. This paper focuses on the possible use of stem
      cells in the two main clinical settings in gastroenterology, i.e., hepatic and
      intestinal diseases, which have a strong impact on public health worldwide.
      Despite encouraging results obtained in both regenerative medicine and
      immune-mediated conditions, further studies are needed to fully understand the
      biology of stem cells and carefully assess their putative oncogenic properties.
      Moreover, the research on stem cells arouses fervent ethical, social and
      political debate. The Italian Society of Gastroenterology sponsored a workshop on
      stem cells held in Verona during the XVI Congress of the Federation of Italian
      Societies of Digestive Diseases (March 6-9, 2010). Here, we report on the issues 
      discussed, including liver and intestinal diseases that may benefit from stem
      cell therapy, the biology of hepatic and intestinal tissue repair, and stem cell 
      usage in clinical trials.
FAU - Burra, Patrizia
AU  - Burra P
AD  - Department of Surgical and Gastroenterological Sciences, Gastroenterology
      Section, University of Padua, 35128 Padova, Italy. burra@unipd.it
FAU - Bizzaro, Debora
AU  - Bizzaro D
FAU - Ciccocioppo, Rachele
AU  - Ciccocioppo R
FAU - Marra, Fabio
AU  - Marra F
FAU - Piscaglia, Anna Chiara
AU  - Piscaglia AC
FAU - Porretti, Laura
AU  - Porretti L
FAU - Gasbarrini, Antonio
AU  - Gasbarrini A
FAU - Russo, Francesco Paolo
AU  - Russo FP
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
SB  - IM
MH  - Adult Stem Cells/*transplantation
MH  - Animals
MH  - Clinical Trials as Topic
MH  - Congresses as Topic
MH  - Digestive System Diseases/pathology/physiopathology/*surgery
MH  - Fibrosis
MH  - Gastroenterology/*methods
MH  - Humans
MH  - Italy
MH  - Neoplastic Stem Cells
MH  - Regenerative Medicine/methods
MH  - *Stem Cell Transplantation
MH  - Transplantation, Autologous
PMC - PMC3198016
OTO - NOTNLM
OT  - Cell therapy
OT  - Inflammatory bowel disease
OT  - Liver disease
OT  - Regenerative me-dicine
OT  - Stem cells
EDAT- 2011/10/26 06:00
MHDA- 2012/01/19 06:00
CRDT- 2011/10/26 06:00
PHST- 2010/12/29 00:00 [received]
PHST- 2011/03/07 00:00 [revised]
PHST- 2011/03/14 00:00 [accepted]
PHST- 2011/10/26 06:00 [entrez]
PHST- 2011/10/26 06:00 [pubmed]
PHST- 2012/01/19 06:00 [medline]
AID - 10.3748/wjg.v17.i34.3870 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2011 Sep 14;17(34):3870-80. doi: 10.3748/wjg.v17.i34.3870.


PMID- 22025818
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 0974-5203 (Electronic)
IS  - 0972-0707 (Linking)
VI  - 14
IP  - 3
DP  - 2011 Jul
TI  - Ethical issues in biomedical research and publication.
PG  - 205-7
LID - 10.4103/0972-0707.85787 [doi]
FAU - Shah, Naseem
AU  - Shah N
AD  - Department of Conservative Dentistry and Endodontics, Centre for Dental Education
      and Research, All India Institute of Medical Sciences, New Delhi - 110 029,
      India. E-mail: naseemys@gmail.com.
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Conserv Dent
JT  - Journal of conservative dentistry : JCD
JID - 101147009
PMC - PMC3198544
EDAT- 2011/10/26 06:00
MHDA- 2011/10/26 06:01
CRDT- 2011/10/26 06:00
PHST- 2011/10/26 06:00 [entrez]
PHST- 2011/10/26 06:00 [pubmed]
PHST- 2011/10/26 06:01 [medline]
AID - 10.4103/0972-0707.85787 [doi]
AID - JCD-14-205 [pii]
PST - ppublish
SO  - J Conserv Dent. 2011 Jul;14(3):205-7. doi: 10.4103/0972-0707.85787.


PMID- 22025732
OWN - NLM
STAT- MEDLINE
DCOM- 20120228
LR  - 20151119
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 262
IP  - 1
DP  - 2012 Jan
TI  - Advanced hemodynamic monitoring before and after transjugular intrahepatic
      portosystemic shunt: implications for selection of patients--a prospective study.
PG  - 343-52
LID - 10.1148/radiol.11110043 [doi]
AB  - PURPOSE: To investigate immediate and short-term effects of transjugular
      intrahepatic portosystemic shunt (TIPS) on cardiocirculatory, hepatic, and renal 
      function and characterize predictors for TIPS outcome in terms of organ function 
      after TIPS. MATERIALS AND METHODS: This prospective study was approved by the
      ethics committee at a university hospital and was conducted in a medical
      intensive care unit. Informed consent was obtained. Twenty patients with
      indication for TIPS were enrolled. Monitoring of hemodynamic and hepatic function
      (transpulmonary thermodilution, indocyanine green plasma disappearance rate
      [ICG-PDR]) was performed. Biochemical markers of organ function were obtained.
      Statistical analysis (Wilcoxon test, Spearman correlation, multivariate linear
      regression analysis, receiver operating characteristic [ROC] analysis) was
      performed. RESULTS: After TIPS, central venous pressure (median, 11 vs 15 cm
      H(2)O; P < .001), cardiac index (3.4 vs 3.8 L/min/m(2); P = .001), and global
      end-diastolic volume index (GEDVI) (726 vs 775 mL/m(2); P = .003) increased
      significantly. Portosystemic pressure gradient (28 vs 11 cm H(2)O; P < .001) and 
      systemic vascular resistance index (1610 vs 1384 dyn . sec . cm(-5) . m(2); P =
      .015) decreased significantly. Creatinine (1.1 vs 1.1 mg/dL; P = .008) and blood 
      urea nitrogen (BUN) (27 vs 21 mg/dL; P = .006) decreased significantly. Bilirubin
      (1.8 vs 2.2 mg/dL; P = .032) and international normalized ratio (1.4 vs 1.5; P = 
      .022) increased significantly. ICG-PDR significantly deteriorated after TIPS (P =
      .006). Higher baseline creatinine was independently associated with a decrease in
      creatinine after TIPS (R = 0.816, P < .001). ROC analysis identified baseline BUN
      (P = .026, area under ROC curve [AUC] = 0.818), cystatin C (P = .033, AUC =
      0.805), and creatinine (P = .052, AUC = 0.779) as predictors of a decrease in
      creatinine of 0.5 mg/dL or greater and/or 25% or greater. An increase in
      bilirubin of 1 mg/dL or greater 1 week after TIPS was significantly associated
      with high baseline BUN (P = .007, AUC = 0.893) and high central venous pressure
      (P = .040, AUC = 0.800). Lower baseline alanine aminotransferase (P = .002, AUC =
      1.000) and cardiac power index . GEDVI (P = .005, AUC = 0.960) predicted
      favorable TIPS outcome (creatinine decrease of >/= 0.2 mg/dL without model for
      end-stage liver disease score increase of more than one point). CONCLUSION:
      Patients with renal insufficiency, compensated hepatocellular function, decreased
      cardiac preload, and decreased cardiac performance benefit most from TIPS.
CI  - (c) RSNA, 2011
FAU - Saugel, Bernd
AU  - Saugel B
AD  - 2nd Medical Department, Klinikum rechts der Isar der Technischen Universitat
      Munchen, Ismaninger Strasse 22, D-81675 Munich, Germany. bcs.muc@gmx.de
FAU - Phillip, Veit
AU  - Phillip V
FAU - Gaa, Jochen
AU  - Gaa J
FAU - Berger, Hermann
AU  - Berger H
FAU - Lersch, Christian
AU  - Lersch C
FAU - Schultheiss, Caroline
AU  - Schultheiss C
FAU - Thies, Philipp
AU  - Thies P
FAU - Schneider, Heike
AU  - Schneider H
FAU - Hollthaler, Josef
AU  - Hollthaler J
FAU - Herrmann, Andrea
AU  - Herrmann A
FAU - Schmid, Roland M
AU  - Schmid RM
FAU - Huber, Wolfgang
AU  - Huber W
LA  - eng
PT  - Journal Article
DEP - 20111024
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Biomarkers)
SB  - IM
MH  - Aged
MH  - Biomarkers/analysis
MH  - Female
MH  - Hemodynamics
MH  - Hospitals, University
MH  - Humans
MH  - Intensive Care Units
MH  - Linear Models
MH  - Liver Function Tests
MH  - Male
MH  - Middle Aged
MH  - Patient Selection
MH  - *Portasystemic Shunt, Transjugular Intrahepatic
MH  - Prospective Studies
MH  - ROC Curve
MH  - Statistics, Nonparametric
MH  - Stents
MH  - Thermodilution
MH  - Treatment Outcome
EDAT- 2011/10/26 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/10/26 06:00
PHST- 2011/10/26 06:00 [entrez]
PHST- 2011/10/26 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - radiol.11110043 [pii]
AID - 10.1148/radiol.11110043 [doi]
PST - ppublish
SO  - Radiology. 2012 Jan;262(1):343-52. doi: 10.1148/radiol.11110043. Epub 2011 Oct
      24.


PMID- 22025263
OWN - NLM
STAT- MEDLINE
DCOM- 20120221
LR  - 20180802
IS  - 1424-3997 (Electronic)
IS  - 0036-7672 (Linking)
VI  - 141
DP  - 2011
TI  - Ethics and non biomedical research with human subjects.
PG  - w13285
LID - 10.4414/smw.2011.13285 [doi]
LID - 2011;141:w13285 [pii]
FAU - Hurst, Samia A
AU  - Hurst SA
LA  - eng
PT  - Editorial
PT  - Research Support, Non-U.S. Gov't
DEP - 20111024
PL  - Switzerland
TA  - Swiss Med Wkly
JT  - Swiss medical weekly
JID - 100970884
SB  - IM
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Switzerland
EDAT- 2011/10/26 06:00
MHDA- 2012/02/22 06:00
CRDT- 2011/10/26 06:00
PHST- 2011/10/26 06:00 [entrez]
PHST- 2011/10/26 06:00 [pubmed]
PHST- 2012/02/22 06:00 [medline]
AID - smw-13285 [pii]
AID - 10.4414/smw.2011.13285 [doi]
PST - epublish
SO  - Swiss Med Wkly. 2011 Oct 24;141:w13285. doi: 10.4414/smw.2011.13285. eCollection 
      2011.


PMID- 22025194
OWN - NLM
STAT- MEDLINE
DCOM- 20121205
LR  - 20151119
IS  - 1470-2738 (Electronic)
IS  - 0143-005X (Linking)
VI  - 66
IP  - 9
DP  - 2012 Sep
TI  - STrengthening the Reporting of OBservational studies in Epidemiology: Molecular
      Epidemiology STROBE-ME. An extension of the STROBE statement.
PG  - 844-54
LID - 10.1136/jech-2011-200318 [doi]
AB  - Advances in laboratory techniques have led to a rapidly increasing use of
      biomarkers in epidemiological studies. Biomarkers of internal dose, early
      biological change, susceptibility, and clinical outcomes are used as proxies for 
      investigating the interactions between external and/or endogenous agents and the 
      body components or processes. The need for improved reporting of scientific
      research led to influential statements of recommendations such as STrengthening
      Reporting of Observational studies in Epidemiology (STROBE) statement. The STROBE
      initiative established in 2004 aimed to provide guidance on how to report
      observational research. Its guidelines provide a user-friendly checklist of 22
      items to be reported in epidemiological studies, with items specific to the three
      main study designs: cohort studies, case-control studies and cross-sectional
      studies. The present STrengthening the Reporting of OBservational studies in
      Epidemiology - Molecular Epidemiology (STROBE-ME) initiative builds on the STROBE
      Statement implementing 9 existing items of STROBE and providing 17 additional
      items to the 22 items of STROBE checklist. The additions relate to the use of
      biomarkers in epidemiological studies, concerning collection, handling and
      storage of biological samples; laboratory methods, validity and reliability of
      biomarkers; specificities of study design; and ethical considerations. The
      STROBE-ME recommendations are intended to complement the STROBE recommendations.
FAU - Gallo, Valentina
AU  - Gallo V
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Imperial
      College London, London, UK.
FAU - Egger, Matthias
AU  - Egger M
FAU - McCormack, Valerie
AU  - McCormack V
FAU - Farmer, Peter B
AU  - Farmer PB
FAU - Ioannidis, John P A
AU  - Ioannidis JP
FAU - Kirsch-Volders, Micheline
AU  - Kirsch-Volders M
FAU - Matullo, Giuseppe
AU  - Matullo G
FAU - Phillips, David H
AU  - Phillips DH
FAU - Schoket, Bernadette
AU  - Schoket B
FAU - Stromberg, Ulf
AU  - Stromberg U
FAU - Vermeulen, Roel
AU  - Vermeulen R
FAU - Wild, Christopher
AU  - Wild C
FAU - Porta, Miquel
AU  - Porta M
FAU - Vineis, Paolo
AU  - Vineis P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111024
PL  - England
TA  - J Epidemiol Community Health
JT  - Journal of epidemiology and community health
JID - 7909766
RN  - 0 (Biomarkers)
SB  - IM
MH  - *Biomarkers
MH  - *Checklist
MH  - *Epidemiologic Research Design
MH  - Female
MH  - Guidelines as Topic
MH  - Health Promotion
MH  - Humans
MH  - Indonesia
MH  - Male
MH  - *Molecular Epidemiology/ethics/standards
MH  - Observation/methods
MH  - Organizational Objectives
MH  - Reproducibility of Results
MH  - Specimen Handling
EDAT- 2011/10/26 06:00
MHDA- 2012/12/10 06:00
CRDT- 2011/10/26 06:00
PHST- 2011/10/26 06:00 [entrez]
PHST- 2011/10/26 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - jech-2011-200318 [pii]
AID - 10.1136/jech-2011-200318 [doi]
PST - ppublish
SO  - J Epidemiol Community Health. 2012 Sep;66(9):844-54. doi:
      10.1136/jech-2011-200318. Epub 2011 Oct 24.


PMID- 22025091
OWN - NLM
STAT- MEDLINE
DCOM- 20120305
LR  - 20111102
IS  - 1751-4266 (Electronic)
IS  - 1751-4258 (Linking)
VI  - 5
IP  - 4
DP  - 2011 Dec
TI  - Do implantable cardioverter defibrillators complicate end-of-life care for those 
      with heart failure?
PG  - 307-11
LID - 10.1097/SPC.0b013e32834d2cce [doi]
AB  - PURPOSE OF REVIEW: We know deactivating implantable cardioverter defibrillators
      (ICDs) is permissible and should not complicate end-of-life care. However,
      patients and healthcare professionals still struggle with this concept. This
      review looks at the recent literature to find possible reasons behind this.
      RECENT FINDINGS: ICD use is on the increase and is not always in accordance with 
      best practice guidelines. The number of clinicians having conversations about
      deactivation is variable, but most of them agree that it is ethical and legal.
      Difficulty in initiating conversations is mainly due to lack of training, viewing
      ICDs as being different to conventional treatments and lack of clarity about
      legality. Patients' knowledge around deactivation and its ethical and legal
      standing is low. This can be improved by giving information about end-of-life
      options at the time of implantation and incorporating these within care plans.
      Use of ICDs should be reviewed in context of disease status and patients' goals. 
      SUMMARY: Deactivation of ICDs at end of life throws up challenges for clinicians 
      and patients. This review points toward a need for communication training for
      clinicians and early initiation of discussion around the time of ICD insertion,
      as well improving clinicians' and patients' knowledge of the ethics and legality 
      of deactivation.
FAU - Waterhouse, Esther
AU  - Waterhouse E
AD  - LOROS Hospice, University Hospitals of Leicester, Leicester University,
      Leicester, UK. estherwaterhouse@loros.co.uk
FAU - Ahmad, Fawad
AU  - Ahmad F
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Support Palliat Care
JT  - Current opinion in supportive and palliative care
JID - 101297402
SB  - IM
MH  - Attitude of Health Personnel
MH  - *Communication
MH  - Decision Support Techniques
MH  - Defibrillators, Implantable/*psychology
MH  - Euthanasia, Passive/*psychology
MH  - Health Knowledge, Attitudes, Practice
MH  - Heart Failure/*psychology/therapy
MH  - Humans
MH  - *Physician-Patient Relations
MH  - Terminal Care/*methods/psychology
EDAT- 2011/10/26 06:00
MHDA- 2012/03/06 06:00
CRDT- 2011/10/26 06:00
PHST- 2011/10/26 06:00 [entrez]
PHST- 2011/10/26 06:00 [pubmed]
PHST- 2012/03/06 06:00 [medline]
AID - 10.1097/SPC.0b013e32834d2cce [doi]
PST - ppublish
SO  - Curr Opin Support Palliat Care. 2011 Dec;5(4):307-11. doi:
      10.1097/SPC.0b013e32834d2cce.


PMID- 22025003
OWN - NLM
STAT- MEDLINE
DCOM- 20120112
LR  - 20111118
IS  - 1471-0064 (Electronic)
IS  - 1471-0056 (Linking)
VI  - 12
IP  - 12
DP  - 2011 Oct 25
TI  - Ethics watch: DNA theft: your genetic information at risk.
PG  - 808
LID - 10.1038/nrg3113 [doi]
FAU - Joh, Elizabeth E
AU  - Joh EE
AD  - UC Davis School of Law, Davis, California 95616, USA. eejoh@ucdavis.edu
LA  - eng
PT  - Journal Article
DEP - 20111025
PL  - England
TA  - Nat Rev Genet
JT  - Nature reviews. Genetics
JID - 100962779
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - *DNA
MH  - Genetic Privacy/economics/*ethics/legislation & jurisprudence
MH  - Humans
MH  - Theft/*ethics/legislation & jurisprudence
MH  - United States
EDAT- 2011/10/26 06:00
MHDA- 2012/01/13 06:00
CRDT- 2011/10/26 06:00
PHST- 2011/10/26 06:00 [entrez]
PHST- 2011/10/26 06:00 [pubmed]
PHST- 2012/01/13 06:00 [medline]
AID - nrg3113 [pii]
AID - 10.1038/nrg3113 [doi]
PST - epublish
SO  - Nat Rev Genet. 2011 Oct 25;12(12):808. doi: 10.1038/nrg3113.


PMID- 22024809
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20111025
IS  - 0047-262X (Print)
VI  - 58
IP  - 5
DP  - 2011 Oct
TI  - [Ethics and laws related to human subject research].
PG  - 89-94
AB  - Advances in medical technology rely on human subject research to test the effects
      on real patients of unproven new drugs, equipment and techniques. Illegal human
      subject research happens occasionally and has led to subject injury and medical
      disputes. Familiarity with the laws and established ethics related to human
      subject research can minimize both injury and disputes. History is a mirror that 
      permits reflection today on past experience. Discussing the Nuremberg Code, the
      Declaration of Helsinki and Belmont Report, this article describes the laws,
      ethics, history and news related to human subject research as well as the current
      definition and characteristics of human subject research. Increasing numbers of
      nurses serve as research nurses and participate in human subject research. The
      authors hope this article can increase research nurse knowledge regarding laws
      and ethics in order to protect human research subjects adequately.
FAU - Chiu, Hui-Ju
AU  - Chiu HJ
AD  - Department of Nursing, National Taipei University of Nursing and Health Sciences,
      Taipei City, Taiwan, ROC. joychiu@ntunhs.edu.tw
FAU - Lee, Ya-Ling
AU  - Lee YL
FAU - Chang, Su-Fen
AU  - Chang SF
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China (Republic : 1949- )
TA  - Hu Li Za Zhi
JT  - Hu li za zhi The journal of nursing
JID - 0073267
SB  - IM
MH  - Helsinki Declaration
MH  - Human Experimentation/*ethics/*legislation & jurisprudence
MH  - Humans
EDAT- 2011/10/26 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/10/26 06:00
PHST- 2011/10/26 06:00 [entrez]
PHST- 2011/10/26 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PST - ppublish
SO  - Hu Li Za Zhi. 2011 Oct;58(5):89-94.


PMID- 22024801
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20111025
IS  - 0047-262X (Print)
VI  - 58
IP  - 5
DP  - 2011 Oct
TI  - [Promoting aesthetics to enhance nursing services].
PG  - 23-8
AB  - Nursing is a client-oriented profession dedicated to helping people. Nurses are
      responsible to both help relieve client physical and psychological symptoms and
      assist clients as necessary to die with dignity. As such, nursing schools should 
      strengthen not only science and professional skills, but also student aesthetics.
      Today, fast changing medical technology is improving the treatment of diseases
      and extending average life spans. The National Health Insurance System in Taiwan,
      however, is increasingly restricting nursing manpower and raising staff
      workloads. Nurses are increasingly required to sacrifice ethical principles and
      conduct technical operations in medical settings defined by stringent cost
      controls. Nursing aesthetics cannot provide appropriate levels of care dignity
      and quality to clients under severe time and emotional distress constraints.
      Burnout, dissatisfaction, strained doctor-nurse relationships and lower quality
      care are all-too-frequent results. Under the circumstances, nursing functions are
      negatively influenced and fine nursing service is difficult to achieve. This
      article reviewed the literature to discuss the definition and meaning of
      aesthetics and relative factors that are difficult to define in clinical
      settings. This article may assist nurses to present aesthetics, upgrade care
      quality and further enhance nursing services.
FAU - Lee, Sheuan
AU  - Lee S
AD  - College of Nursing, Chung-Shan Medical University, Taichung City, Taiwan, ROC.
FAU - Chang, Ting
AU  - Chang T
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China (Republic : 1949- )
TA  - Hu Li Za Zhi
JT  - Hu li za zhi The journal of nursing
JID - 0073267
SB  - IM
MH  - *Esthetics
MH  - Humans
MH  - Nursing Services/*standards
EDAT- 2011/10/26 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/10/26 06:00
PHST- 2011/10/26 06:00 [entrez]
PHST- 2011/10/26 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PST - ppublish
SO  - Hu Li Za Zhi. 2011 Oct;58(5):23-8.


PMID- 22024726
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111219
LR  - 20220129
IS  - 1569-8041 (Electronic)
IS  - 0923-7534 (Linking)
VI  - 22
IP  - 11
DP  - 2011 Nov
TI  - Retraction.
PG  - 2536
LID - S0923-7534(19)37728-2 [pii]
LID - 10.1093/annonc/mdr479 [doi]
AB  - The editors of Journal of Clinical Oncology identified a published paper in
      Annals of Oncology that appeared to represent a case of redundant publication
      involving the following articles: Long-term survival results of a randomized
      trial comparing gemcitabine plus cisplatin, with methotrexate,
      vinblastine,doxorubicin, plus cisplatin in patients with bladder cancer. Hans von
      der Maase, Lisa Sengelov, James T. Roberts, Sergio Ricci, Luigi Dogliotti, T.
      Oliver, Malcolm J. Moore, Annamaria Zimmermann, and Michael Arning. J Clin Oncol 
      2005; 23: 4602-4608. DOI:10.1200/JCO.2005.07.757. Long-term survival results of a
      randomized trial comparing gemcitabine/cisplatin and
      methotrexate/vinblastine/doxorubicin/cisplatin in patients with locally advanced 
      and metastatic bladder cancer. J. T. Roberts, H. von der Maase, L. Sengelov, P.
      F. Conte, L. Dogliotti, T. Oliver, M. J. Moore, A. Zimmermann and M. Arning. Ann 
      Oncol 2006; 17 (Supplement 5): v 118-v 122. DOI:10.1093/annonc/mdj965. Following 
      the Committee on Publication Ethics guidelines, the editors of Annals of Oncology
      have analyzed these two articles and after communication with several of the
      authors have confirmed that this in indeed the case and we, the editors, hereby
      retract the redundant Annals article to correct the published record. Annals of
      Oncology apologizes on behalf of all concerned.
LA  - eng
GR  - 11700/CRUK_/Cancer Research UK/United Kingdom
PT  - Retraction of Publication
PL  - England
TA  - Ann Oncol
JT  - Annals of oncology : official journal of the European Society for Medical
      Oncology
JID - 9007735
ROF - Roberts JT, von der Maase H, Sengelov L, Conte PF, Dogliotti L, Oliver T, Moore
      MJ, Zimmermann A, Arning M. Ann Oncol. 2006 May;17 Suppl 5:v118-22. PMID:
      16807438
EDAT- 2011/10/26 06:00
MHDA- 2011/12/20 06:00
CRDT- 2011/10/26 06:00
PHST- 2011/10/26 06:00 [entrez]
PHST- 2011/10/26 06:00 [pubmed]
PHST- 2011/12/20 06:00 [medline]
AID - S0923-7534(19)37728-2 [pii]
AID - 10.1093/annonc/mdr479 [doi]
PST - ppublish
SO  - Ann Oncol. 2011 Nov;22(11):2536. doi: 10.1093/annonc/mdr479.


PMID- 22024685
OWN - NLM
STAT- MEDLINE
DCOM- 20120221
LR  - 20111025
IS  - 1538-9855 (Electronic)
IS  - 0363-3624 (Linking)
VI  - 36
IP  - 6
DP  - 2011 Nov-Dec
TI  - Student-generated behavioral guidelines to inform ethical practice: a quality
      improvement project.
PG  - 271-5
LID - 10.1097/NNE.0b013e3182333fbb [doi]
AB  - Nursing faculty members have become increasingly concerned with student
      incidences of cheating and the associated lack of commitment to ethical conduct. 
      Our faculty believed that actively engaging students in the development of
      specific behavioral guidelines would result in improved ethical conduct and
      provide a bridge to future professional ethical practice. The authors discuss the
      use of focus groups to establish clear behavioral guidelines that align with the 
      American Nurses Association Code of Ethics.
FAU - Wilk, Nancy
AU  - Wilk N
AD  - Wegmans School of Nursing, St John Fisher College, Rochester, New York 14618,
      USA. nwilk@sjfc.edu
FAU - Bowllan, Nancy
AU  - Bowllan N
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Nurse Educ
JT  - Nurse educator
JID - 7701902
MH  - Adult
MH  - American Nurses' Association
MH  - *Attitude of Health Personnel
MH  - *Codes of Ethics
MH  - Deception
MH  - Education, Nursing/methods/*standards
MH  - *Ethics, Nursing
MH  - Focus Groups
MH  - Guidelines as Topic
MH  - Humans
MH  - Middle Aged
MH  - Nursing Education Research
MH  - *Quality Improvement
MH  - Students, Nursing/*psychology
MH  - United States
MH  - Young Adult
EDAT- 2011/10/26 06:00
MHDA- 2012/02/22 06:00
CRDT- 2011/10/26 06:00
PHST- 2011/10/26 06:00 [entrez]
PHST- 2011/10/26 06:00 [pubmed]
PHST- 2012/02/22 06:00 [medline]
AID - 10.1097/NNE.0b013e3182333fbb [doi]
AID - 00006223-201111000-00017 [pii]
PST - ppublish
SO  - Nurse Educ. 2011 Nov-Dec;36(6):271-5. doi: 10.1097/NNE.0b013e3182333fbb.


PMID- 22023950
OWN - NLM
STAT- MEDLINE
DCOM- 20120217
LR  - 20161125
IS  - 1615-5947 (Electronic)
IS  - 0890-5096 (Linking)
VI  - 25
IP  - 8
DP  - 2011 Nov
TI  - OMNEX surgical sealant in the extracorporeal repair of renal artery aneurysms.
PG  - 1141.e5-8
LID - 10.1016/j.avsg.2011.07.009 [doi]
AB  - OMNEX (Ethicon, Inc.; Somerville, NJ) is a cyanoacrylate-based synthetic surgical
      sealant. To date, the use of OMNEX has only been described in a limited number of
      vascular surgery procedures. We present the cases of two patients who underwent
      successful extracorporeal renal artery aneurysm repair with the aid of OMNEX
      sealant. This report is the first evidence to suggest the utility of OMNEX in
      renovascular surgery.
CI  - Copyright (c) 2011 Annals of Vascular Surgery Inc. Published by Elsevier Inc. All
      rights reserved.
FAU - Garcia-Roig, Michael
AU  - Garcia-Roig M
AD  - Department of Urology, University of Miami Miller School of Medicine, Miami, FL
      33101, USA.
FAU - Gorin, Michael A
AU  - Gorin MA
FAU - Castellan, Miguel
AU  - Castellan M
FAU - Ciancio, Gaetano
AU  - Ciancio G
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Netherlands
TA  - Ann Vasc Surg
JT  - Annals of vascular surgery
JID - 8703941
RN  - 0 (Cyanoacrylates)
RN  - 0 (Tissue Adhesives)
SB  - IM
MH  - Aneurysm/diagnostic imaging/*surgery
MH  - Cyanoacrylates/*therapeutic use
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Renal Artery/diagnostic imaging/*surgery
MH  - Tissue Adhesives/*therapeutic use
MH  - Tomography, X-Ray Computed
MH  - Treatment Outcome
MH  - *Vascular Surgical Procedures
EDAT- 2011/10/26 06:00
MHDA- 2012/02/18 06:00
CRDT- 2011/10/26 06:00
PHST- 2011/04/15 00:00 [received]
PHST- 2011/07/03 00:00 [revised]
PHST- 2011/07/27 00:00 [accepted]
PHST- 2011/10/26 06:00 [entrez]
PHST- 2011/10/26 06:00 [pubmed]
PHST- 2012/02/18 06:00 [medline]
AID - S0890-5096(11)00362-1 [pii]
AID - 10.1016/j.avsg.2011.07.009 [doi]
PST - ppublish
SO  - Ann Vasc Surg. 2011 Nov;25(8):1141.e5-8. doi: 10.1016/j.avsg.2011.07.009.


PMID- 22023344
OWN - NLM
STAT- MEDLINE
DCOM- 20120405
LR  - 20220316
IS  - 1365-2362 (Electronic)
IS  - 0014-2972 (Linking)
VI  - 42
IP  - 1
DP  - 2012 Jan
TI  - STrengthening the Reporting of OBservational studies in Epidemiology - Molecular 
      Epidemiology (STROBE-ME): an extension of the STROBE statement.
PG  - 1-16
LID - 10.1111/j.1365-2362.2011.02561.x [doi]
AB  - Advances in laboratory techniques have led to a rapidly increasing use of
      biomarkers in epidemiological studies. Biomarkers of internal dose, early
      biological change, susceptibility and clinical outcomes are used as proxies for
      investigating interactions between external and/or endogenous agents and body
      components or processes. The need for improved reporting of scientific research
      led to influential statements of recommendations such as the STrengthening
      Reporting of OBservational studies in Epidemiology (STROBE) statement. The STROBE
      initiative established in 2004 aimed to provide guidance on how to report
      observational research. Its guidelines provide a user-friendly checklist of 22
      items to be reported in epidemiological studies, with items specific to the three
      main study designs: cohort studies, case-control studies and cross-sectional
      studies. The present STrengthening the Reporting of OBservational studies in
      Epidemiology -Molecular Epidemiology (STROBE-ME) initiative builds on the STROBE 
      statement implementing nine existing items of STROBE and providing 17 additional 
      items to the 22 items of STROBE checklist. The additions relate to the use of
      biomarkers in epidemiological studies, concerning collection, handling and
      storage of biological samples; laboratory methods, validity and reliability of
      biomarkers; specificities of study design; and ethical considerations. The
      STROBE-ME recommendations are intended to complement the STROBE recommendations.
CI  - (c) 2011 The Authors. European Journal of Clinical Investigation (c) 2011
      Stichting European Society for Clinical Investigation Journal Foundation.
FAU - Gallo, Valentina
AU  - Gallo V
AD  - Department of Epidemiology and Biostatistics, Imperial College London, London,
      UK. v.gallo@imperial.ac.uk
FAU - Egger, Matthias
AU  - Egger M
FAU - McCormack, Valerie
AU  - McCormack V
FAU - Farmer, Peter B
AU  - Farmer PB
FAU - Ioannidis, John P A
AU  - Ioannidis JP
FAU - Kirsch-Volders, Micheline
AU  - Kirsch-Volders M
FAU - Matullo, Giuseppe
AU  - Matullo G
FAU - Phillips, David H
AU  - Phillips DH
FAU - Schoket, Bernadette
AU  - Schoket B
FAU - Stromberg, Ulf
AU  - Stromberg U
FAU - Vermeulen, Roel
AU  - Vermeulen R
FAU - Wild, Christopher
AU  - Wild C
FAU - Porta, Miquel
AU  - Porta M
FAU - Vineis, Paolo
AU  - Vineis P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111025
PL  - England
TA  - Eur J Clin Invest
JT  - European journal of clinical investigation
JID - 0245331
RN  - 0 (Biomarkers)
SB  - IM
EIN - Eur J Clin Invest. 2012 Apr;42(4):462
MH  - *Biomarkers
MH  - Checklist
MH  - *Epidemiologic Research Design
MH  - *Epidemiologic Studies
MH  - Evidence-Based Medicine/*methods/standards
MH  - Humans
MH  - Molecular Epidemiology/*methods/standards
MH  - Observation/*methods
MH  - Practice Guidelines as Topic
MH  - Publishing/standards
MH  - Reference Standards
MH  - Reproducibility of Results
EDAT- 2011/10/26 06:00
MHDA- 2012/04/06 06:00
CRDT- 2011/10/26 06:00
PHST- 2011/10/26 06:00 [entrez]
PHST- 2011/10/26 06:00 [pubmed]
PHST- 2012/04/06 06:00 [medline]
AID - 10.1111/j.1365-2362.2011.02561.x [doi]
PST - ppublish
SO  - Eur J Clin Invest. 2012 Jan;42(1):1-16. doi: 10.1111/j.1365-2362.2011.02561.x.
      Epub 2011 Oct 25.


PMID- 22022152
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 0976-2809 (Electronic)
IS  - 0975-9476 (Linking)
VI  - 2
IP  - 3
DP  - 2011 Jul
TI  - A critique of statistical hypothesis testing in clinical research.
PG  - 105-14
LID - 10.4103/0975-9476.85548 [doi]
AB  - Many have documented the difficulty of using the current paradigm of Randomized
      Controlled Trials (RCTs) to test and validate the effectiveness of alternative
      medical systems such as Ayurveda. This paper critiques the applicability of RCTs 
      for all clinical knowledge-seeking endeavors, of which Ayurveda research is a
      part. This is done by examining statistical hypothesis testing, the underlying
      foundation of RCTs, from a practical and philosophical perspective. In the
      philosophical critique, the two main worldviews of probability are that of the
      Bayesian and the frequentist. The frequentist worldview is a special case of the 
      Bayesian worldview requiring the unrealistic assumptions of knowing nothing about
      the universe and believing that all observations are unrelated to each other.
      Many have claimed that the first belief is necessary for science, and this claim 
      is debunked by comparing variations in learning with different prior beliefs.
      Moving beyond the Bayesian and frequentist worldviews, the notion of hypothesis
      testing itself is challenged on the grounds that a hypothesis is an unclear
      distinction, and assigning a probability on an unclear distinction is an exercise
      that does not lead to clarity of action. This critique is of the theory itself
      and not any particular application of statistical hypothesis testing. A
      decision-making frame is proposed as a way of both addressing this critique and
      transcending ideological debates on probability. An example of a Bayesian
      decision-making approach is shown as an alternative to statistical hypothesis
      testing, utilizing data from a past clinical trial that studied the effect of
      Aspirin on heart attacks in a sample population of doctors. As a big reason for
      the prevalence of RCTs in academia is legislation requiring it, the ethics of
      legislating the use of statistical methods for clinical research is also
      examined.
FAU - Raha, Somik
AU  - Raha S
AD  - Independent Researcher, California, USA .
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Ayurveda Integr Med
JT  - Journal of Ayurveda and integrative medicine
JID - 101551404
PMC - PMC3193681
OTO - NOTNLM
OT  - Bayesian
OT  - decision analysis
OT  - statistical hypothesis testing
EDAT- 2011/10/25 06:00
MHDA- 2011/10/25 06:01
CRDT- 2011/10/25 06:00
PHST- 2011/07/01 00:00 [received]
PHST- 2011/08/15 00:00 [revised]
PHST- 2011/08/22 00:00 [accepted]
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/10/25 06:00 [pubmed]
PHST- 2011/10/25 06:01 [medline]
AID - 10.4103/0975-9476.85548 [doi]
AID - JAIM-2-105 [pii]
PST - ppublish
SO  - J Ayurveda Integr Med. 2011 Jul;2(3):105-14. doi: 10.4103/0975-9476.85548.


PMID- 22022059
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1998-3824 (Electronic)
IS  - 0970-1591 (Linking)
VI  - 27
IP  - 3
DP  - 2011 Jul
TI  - Herbo-mineral supplementation in men with idiopathic oligoasthenoteratospermia : 
      A double blind randomized placebo-controlled trial.
PG  - 357-62
LID - 10.4103/0970-1591.85440 [doi]
AB  - INTRODUCTION: There is insufficient scientific data on the medical management
      options for idiopathic oligoasthenoteratospermia (iOATs). We conducted a double
      blind, randomized, placebo-controlled trial to assess the efficacy and safety of 
      the herbo-mineral supplement, Addyzoa((R)), in infertile men with iOATs. We also 
      evaluated its effect on semen reactive oxygen species (ROS) levels, total
      antioxidant capacity (TAC) and DNA fragmentation index. MATERIALS AND METHODS:
      Fifty infertile men with iOATS were recruited into an institutional ethics
      committee approved protocol from April to August 2009. Randomization was done
      using numbered, identical containers. Baseline semen samples were evaluated for
      routine parameters, ROS level, DNA fragmentation index and TAC. Drug/placebo was 
      administered at a dose of two capsules twice a day for 3 months. All parameters
      were reassessed at 3 months and clinical side-effects were recorded. The study
      was registered with the Clinical Trials Registry of India and is available at
      www.ctri.in as study protocol number CTRI/2009/091/000551. RESULTS: Forty-four
      subjects completed the study, 21 in the drug arm and 23 in the placebo arm. There
      was no difference in baseline parameters between the two groups. Men in the drug 
      group had significant improvement in mean total motility from 23.2 +/- 17.3% to
      33.4 +/- 23.2% (P-value: 0.008) and mean progressive (Type A+B) motility from
      15.7 +/- 12.6% to 22.6 +/- 18.0% (P-value: 0.024). ROS, TAC and DFI did not
      change significantly in either group and did not show any correlation with other 
      semen parameters. CONCLUSIONS: Treatment with Addyzoa resulted in a significant
      improvement in total and progressive motility in the semen of men with iOATs
      after 3 months of therapy. There was no change in the sperm concentration, ROS,
      DFI or TAC levels.
FAU - Kumar, Rajeev
AU  - Kumar R
AD  - Department of Urology, All India Institute of Medical Sciences, New Delhi, India.
FAU - Saxena, Vaibhav
AU  - Saxena V
FAU - Shamsi, Monis Bilal
AU  - Shamsi MB
FAU - Venkatesh, S
AU  - Venkatesh S
FAU - Dada, Rima
AU  - Dada R
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Urol
JT  - Indian journal of urology : IJU : journal of the Urological Society of India
JID - 8510441
PMC - PMC3193736
OTO - NOTNLM
OT  - Antioxidant
OT  - drug therapy
OT  - idiopathic
OT  - infertility
OT  - oxidative stress
EDAT- 2011/10/25 06:00
MHDA- 2011/10/25 06:01
CRDT- 2011/10/25 06:00
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/10/25 06:00 [pubmed]
PHST- 2011/10/25 06:01 [medline]
AID - 10.4103/0970-1591.85440 [doi]
AID - IJU-27-357 [pii]
PST - ppublish
SO  - Indian J Urol. 2011 Jul;27(3):357-62. doi: 10.4103/0970-1591.85440.


PMID- 22022023
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 0964-1998 (Print)
IS  - 0964-1998 (Linking)
VI  - 174
IP  - 4
DP  - 2011 Oct
TI  - A Stochastic Model for Assessing Chlamydia trachomatis Transmission Risk Using
      Longitudinal Observational Data.
PG  - 975-989
AB  - Bacterium Chlamydia trachomatis causes genital chlamydia infection. Yet little is
      known about the transmission efficiency of this organism. Ethical constraint
      against exposing healthy subjects to infected partners precludes the possibility 
      of quantifying transmission risk through controlled experiments. This research
      proposes an alternative strategy that relies on observational data. Specifically,
      we present a stochastic model that treats longitudinally observed infection
      states in a group of young women as a Markov process. The proposed model
      explicitly accommodates the parameters of C. trachomatis transmission, including 
      per-encounter sexually transmitted infection (STI) acquisition risks, with and
      without condom protection, and the probability of antibiotic treatment failure.
      The male-to-female transmission probability of C. trachomatis is then estimated
      by combining the per-encounter disease acquisition risk and the organism's
      prevalence in the male partner population. The proposed model is fitted in a
      Bayesian computational framework.
FAU - Tu, Wanzhu
AU  - Tu W
FAU - Ghosh, Pulak
AU  - Ghosh P
FAU - Katz, Barry P
AU  - Katz BP
LA  - eng
GR  - R01 HD042404/HD/NICHD NIH HHS/United States
GR  - R01 HD042404-03/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J R Stat Soc Ser A Stat Soc
JT  - Journal of the Royal Statistical Society. Series A, (Statistics in Society)
JID - 9001406
PMC - PMC3197250
MID - NIHMS321274
EDAT- 2011/10/25 06:00
MHDA- 2011/10/25 06:01
CRDT- 2011/10/25 06:00
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/10/25 06:00 [pubmed]
PHST- 2011/10/25 06:01 [medline]
AID - 10.1111/j.1467-985X.2011.00691.x [doi]
PST - ppublish
SO  - J R Stat Soc Ser A Stat Soc. 2011 Oct;174(4):975-989. doi:
      10.1111/j.1467-985X.2011.00691.x.


PMID- 22021978
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 2589-0565 (Electronic)
IS  - 2589-0557 (Linking)
VI  - 32
IP  - 2
DP  - 2011 Jul
TI  - Ethical considerations in scientific writing.
PG  - 124-8
LID - 10.4103/0253-7184.85425 [doi]
FAU - Carver, Jane D
AU  - Carver JD
AD  - Department of Pediatrics, University of South Florida, and Clinical and
      Translational Science Institute (USF-CTSI), Tampa, Florida, USA.
FAU - Dellva, Ben
AU  - Dellva B
FAU - Emmanuel, Patricia J
AU  - Emmanuel PJ
FAU - Parchure, Ritu
AU  - Parchure R
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Sex Transm Dis AIDS
JT  - Indian journal of sexually transmitted diseases and AIDS
JID - 101730896
PMC - PMC3195176
EDAT- 2011/10/25 06:00
MHDA- 2011/10/25 06:01
CRDT- 2011/10/25 06:00
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/10/25 06:00 [pubmed]
PHST- 2011/10/25 06:01 [medline]
AID - 10.4103/0253-7184.85425 [doi]
AID - IJSTD-32-124 [pii]
PST - ppublish
SO  - Indian J Sex Transm Dis AIDS. 2011 Jul;32(2):124-8. doi: 10.4103/0253-7184.85425.


PMID- 22021885
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 1
IP  - 2
DP  - 2011 Jan 1
TI  - Protocol for a randomised controlled trial to improve cognitive functioning in
      older adults: the Iowa Healthy and Active Minds Study.
PG  - e000218
LID - 10.1136/bmjopen-2011-000218 [doi]
AB  - OBJECTIVES: Gradual age-related cognitive deteriorations are common and are
      hypothesised to be partially attributable to declines in information-processing
      speed. The Iowa Healthy and Active Minds Study will evaluate the efficacy and
      effectiveness of a computerised visual processing speed training programme (Road 
      Tour, Posit Science Corporation, San Francisco, California). METHODS AND
      ANALYSIS: Using a 3:3:4:4 ratio within two age strata (50-64 vs >/= 65 years
      old), 681 men and women attending family care clinics were randomised to four
      treatment groups: 10 h of on-site Road Tour training, 10 h of on-site Road Tour
      training with 4 h of booster training at 11 months postrandomisation, 10 h of
      on-site attention control using computerised crossword puzzles (Boatload of
      Crosswords, Boatload Puzzles, LLC, Yorktown Heights, New York) and 10 h of
      at-home Road Tour training using the participant's personal computer. The primary
      outcome, visual processing speed, was assessed at randomisation and post-training
      (6-8 weeks postrandomisation), and is being reassessed at 1-year
      postrandomisation using the Useful Field of View test. Five secondary outcomes
      (Symbol Digit Modalities Test, Trail Making Tests A and B, Controlled Oral Word
      Association Test, Digit Vigilance Test, and the Stroop Colour and Word Test) were
      assessed at randomisation and will be reassessed at 1-year postrandomisation.
      Seven hypotheses will be tested using intent-to-treat analyses involving multiple
      linear, logistic, Poisson and negative binomial regression. ETHICS AND
      DISSEMINATION: Ethics approval was provided by the University of Iowa
      Institutional Review Board (IRB-03 protocol 200908789). All participants
      completed signed informed consent prior to enrollment. Road Tour is commercially 
      available from Posit Science Corporation, which provided it to Iowa Healthy and
      Active Minds Study at no cost. All participants will receive a free copy of Road 
      Tour for unlimited perpetual use at study completion. Clinical Trial Registration
      Number NCT01165463.
FAU - Wolinsky, Fredric D
AU  - Wolinsky FD
AD  - Department of Health Management and Policy, University of Iowa, Iowa City, Iowa, 
      USA. fredric-wolinsky@uiowa.edu
FAU - Vander Weg, Mark W
AU  - Vander Weg MW
FAU - Howren, M Bryant
AU  - Howren MB
FAU - Jones, Michael P
AU  - Jones MP
FAU - Martin, Rene
AU  - Martin R
FAU - Luger, Tana M
AU  - Luger TM
FAU - Duff, Kevin
AU  - Duff K
FAU - Goerdt, Christopher
AU  - Goerdt C
FAU - Wolfe, Steven
AU  - Wolfe S
FAU - Dotson, Megan M
AU  - Dotson MM
LA  - eng
SI  - ClinicalTrials.gov/NCT01165463
GR  - RC1 AG035546/AG/NIA NIH HHS/United States
GR  - RC1 AG-035546/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3191599
EDAT- 2011/10/25 06:00
MHDA- 2011/10/25 06:01
CRDT- 2011/10/25 06:00
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/10/25 06:00 [pubmed]
PHST- 2011/10/25 06:01 [medline]
AID - bmjopen-2011-000218 [pii]
AID - 10.1136/bmjopen-2011-000218 [doi]
PST - ppublish
SO  - BMJ Open. 2011 Jan 1;1(2):e000218. doi: 10.1136/bmjopen-2011-000218.


PMID- 22021876
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 1
IP  - 2
DP  - 2011 Jan 1
TI  - Meeting the demand for more sophisticated study designs. A proposal for a new
      type of clinical trial: the hybrid design.
PG  - e000156
LID - 10.1136/bmjopen-2011-000156 [doi]
AB  - Background Treatment effect is traditionally assessed through either superiority 
      or non-inferiority clinical trials. Investigators may find that because of safety
      concerns and/or wide variability across strata of the superiority margin of
      active controls over placebo, neither a superiority nor a non-inferiority trial
      design is ethical or practical in some disease populations. Prior knowledge may
      allow and drive study designers to consider more sophisticated designs for a
      clinical trial. Design In this paper, the authors propose hybrid designs which
      may combine a superiority design in one subgroup with a non-inferiority design in
      another subgroup or combine designs with different control regimens in different 
      subgroups in one trial when a uniform design is unethical or impractical. The
      authors show how the hybrid design can be planned and how inferences can be made.
      Through two examples, the authors illustrate the scenarios where hybrid designs
      are useful while the conventional designs are not preferable. Conclusion The
      hybrid design is a useful alternative to current superiority and non-inferiority 
      designs.
FAU - Soon, Guoxing G
AU  - Soon GG
AD  - Division of Biometrics IV, Office of Biostatistics/OTS/CDER/FDA, Silver Spring,
      Maryland, USA.
FAU - Nie, Lei
AU  - Nie L
FAU - Hammerstrom, Thomas
AU  - Hammerstrom T
FAU - Zeng, Wen
AU  - Zeng W
FAU - Chu, Haitao
AU  - Chu H
LA  - eng
PT  - Journal Article
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3191591
EDAT- 2011/10/25 06:00
MHDA- 2011/10/25 06:01
CRDT- 2011/10/25 06:00
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/10/25 06:00 [pubmed]
PHST- 2011/10/25 06:01 [medline]
AID - bmjopen-2011-000156 [pii]
AID - 10.1136/bmjopen-2011-000156 [doi]
PST - ppublish
SO  - BMJ Open. 2011 Jan 1;1(2):e000156. doi: 10.1136/bmjopen-2011-000156.


PMID- 22021870
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20220409
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 1
IP  - 2
DP  - 2011 Jan 1
TI  - A manual physical therapy approach versus subacromial corticosteroid injection
      for treatment of shoulder impingement syndrome: a protocol for a randomised
      clinical trial.
PG  - e000137
LID - 10.1136/bmjopen-2011-000137 [doi]
AB  - INTRODUCTION: Corticosteroid injections (CSI) are a recommended and often-used
      first-line intervention for shoulder impingement syndrome (SIS) in primary care
      and orthopaedic settings. Manual physical therapy (MPT) offers a non-invasive
      approach with negligible risk for managing SIS. There is limited evidence to
      suggest significant long-term improvements in pain, strength and disability with 
      the use of MPT, and there are conflicting reports from systematic reviews that
      question the long-term efficacy of CSI. Specifically, the primary objective is to
      compare the effect of CSI and MPT on pain and disability in subjects with SIS at 
      12 months. DESIGN: This pragmatic randomised clinical trial will be a mixed-model
      2x5 factorial design. The independent variables are treatment (MPT and CSI) and
      time with five levels from baseline to 1 year. The primary dependent variable is 
      the Shoulder Pain and Disability Index, and the secondary outcome measures are
      the Global Rating of Change and the Numeric Pain Rating Scale. For each ANOVA,
      the hypothesis of interest will be the two-way group-by-time interaction. METHODS
      AND ANALYSIS: The authors plan to recruit 104 participants meeting established
      impingement criteria. Following examination and enrollment, eligible participants
      will be randomly allocated to receive a pragmatic approach of either CSI or MPT. 
      The MPT intervention will consist of six sessions, and the CSI intervention will 
      consist of one to three sessions. All subjects will continue to receive usual
      care. Subjects will be followed for 12 months. DISSEMINATION AND ETHICS: The
      protocol was approved by the Madigan Army Medical Center Institutional Review
      Board. The results may have an impact on clinical practice guidelines. This study
      was funded in part by the Orthopaedic Physical Therapy Products Grant through the
      American Academy of Orthopaedic Manual Physical Therapists. Trial Registration
      http://clinicaltrials.gov/ NCT01190891.
FAU - Rhon, Daniel I
AU  - Rhon DI
AD  - Department of Physical Medicine, Madigan Army Medical Center, Tacoma, Washington,
      USA. dirhon@gmail.com
FAU - Boyles, Robert E
AU  - Boyles RE
FAU - Cleland, Joshua A
AU  - Cleland JA
FAU - Brown, David L
AU  - Brown DL
LA  - eng
SI  - ClinicalTrials.gov/NCT01190891
PT  - Journal Article
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3191586
EDAT- 2011/10/25 06:00
MHDA- 2011/10/25 06:01
CRDT- 2011/10/25 06:00
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/10/25 06:00 [pubmed]
PHST- 2011/10/25 06:01 [medline]
AID - bmjopen-2011-000137 [pii]
AID - 10.1136/bmjopen-2011-000137 [doi]
PST - ppublish
SO  - BMJ Open. 2011 Jan 1;1(2):e000137. doi: 10.1136/bmjopen-2011-000137.


PMID- 22021867
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 1
IP  - 2
DP  - 2011 Jan 1
TI  - A cluster randomised controlled trial of a comprehensive accreditation
      intervention to reduce alcohol consumption at community sports clubs: study
      protocol.
PG  - bmjopen2011000328
LID - 10.1136/bmjopen-2011-000328 [doi]
AB  - Introduction Excessive alcohol consumption is responsible for considerable harm
      from chronic disease and injury. Within most developed countries, members of
      sporting clubs consume alcohol at levels above that of communities generally.
      Despite the potential benefits of interventions to address alcohol consumption in
      sporting clubs, there have been no randomised controlled trials to test the
      effectiveness of these interventions. The aim of this study is to examine the
      effectiveness of a comprehensive accreditation intervention with community
      football clubs (Rugby League, Rugby Union, soccer/association football and
      Australian Rules football) in reducing excessive alcohol consumption by club
      members. Methods and analysis The study will be conducted in New South Wales,
      Australia, and employ a cluster randomised controlled trial design. Half of the
      football clubs recruited to the trial will be randomised to receive an
      intervention implemented over two and a half winter sporting seasons. The
      intervention is based on social ecology theory and is comprehensive in nature,
      containing multiple elements designed to decrease the supply of alcohol to
      intoxicated members, cease the provision of cheap and free alcohol, increase the 
      availability and cost-attractiveness of non-alcoholic and low-alcoholic
      beverages, remove high alcohol drinks and cease drinking games. The intervention 
      utilises a three-tiered accreditation framework designed to motivate intervention
      implementation. Football clubs in the control group will receive printed
      materials on topics unrelated to alcohol. Outcome data will be collected pre- and
      postintervention through cross-sectional telephone surveys of club members. The
      primary outcome measure will be alcohol consumption by club members at the club, 
      assessed using a graduated frequency index and a seven day diary. Ethics and
      dissemination The study was approved by The University of Newcastle Human
      Research Ethics Committee (reference: H-2008-0432). Study findings will be
      disseminated widely through peer-reviewed publications and conference
      presentations. Trial registration number Australian New Zealand Clinical Trials
      Registry: ACTRN12609000224224.
FAU - Kingsland, Melanie
AU  - Kingsland M
AD  - School of Medicine and Public Health, The University of Newcastle, Callaghan, New
      South Wales, Australia.
FAU - Wolfenden, Luke
AU  - Wolfenden L
FAU - Rowland, Bosco C
AU  - Rowland BC
FAU - Tindall, Jennifer
AU  - Tindall J
FAU - Gillham, Karen E
AU  - Gillham KE
FAU - McElduff, Patrick
AU  - McElduff P
FAU - Rogerson, John C
AU  - Rogerson JC
FAU - Wiggers, John H
AU  - Wiggers JH
LA  - eng
PT  - Journal Article
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3191607
EDAT- 2011/10/25 06:00
MHDA- 2011/10/25 06:01
CRDT- 2011/10/25 06:00
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/10/25 06:00 [pubmed]
PHST- 2011/10/25 06:01 [medline]
AID - bmjopen-2011-000328 [pii]
AID - 10.1136/bmjopen-2011-000328 [doi]
PST - ppublish
SO  - BMJ Open. 2011 Jan 1;1(2):bmjopen2011000328. doi: 10.1136/bmjopen-2011-000328.


PMID- 22021785
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 1
IP  - 1
DP  - 2011 Jun 30
TI  - The clinical diagnostic accuracy of rapid detection of healthcare-associated
      bloodstream infection in intensive care using multipathogen real-time PCR
      technology.
PG  - e000181
LID - 10.1136/bmjopen-2011-000181 [doi]
AB  - Background There is growing interest in the potential utility of real-time PCR in
      diagnosing bloodstream infection by detecting pathogen DNA in blood samples
      within a few hours. SeptiFast is a multipathogen probe-based real-time PCR system
      targeting ribosomal DNA sequences of bacteria and fungi. It detects and
      identifies the commonest pathogens causing bloodstream infection and has European
      regulatory approval. The SeptiFast pathogen panel is suited to identifying
      healthcare-associated bloodstream infection acquired during complex healthcare,
      and the authors report here the protocol for the first detailed health-technology
      assessment of multiplex real-time PCR in this setting. Methods/design A Phase III
      multicentre double-blinded diagnostic study will determine the clinical validity 
      of SeptiFast for the rapid detection of healthcare-associated bloodstream
      infection, against the current service standard of microbiological culture, in an
      adequately sized population of critically ill adult patients. Results from
      SeptiFast and standard microbiological culture procedures in each patient will be
      compared at study conclusion and the metrics of clinical diagnostic accuracy of
      SeptiFast determined in this population setting. In addition, this study aims to 
      assess further the preliminary evidence that the detection of pathogen DNA in the
      bloodstream using SeptiFast may have value in identifying the presence of
      infection elsewhere in the body. Furthermore, differences in circulating
      immune-inflammatory markers in patient groups differentiated by the
      presence/absence of culturable pathogens and pathogen DNA will help elucidate
      further the patho-physiology of infection developing in the critically ill.
      Ethics and dissemination Ethical approval has been granted by the North West 6
      Research Ethics Committee (09/H1003/109). Based on the results of this first
      non-commercial study, independent recommendations will be made to The Department 
      of Health (open-access health technology assessment report) as to whether
      SeptiFast has sufficient clinical diagnostic accuracy to move forward to efficacy
      testing during the provision of routine clinical care.
FAU - Dark, Paul
AU  - Dark P
AD  - Infection, Injury and Inflammation Research Group, Biomedical Facility, Clinical 
      Sciences, Manchester Academic Health Sciences Centre, Salford Royal NHS
      Foundation Trust, Salford, UK.
FAU - Dunn, Graham
AU  - Dunn G
FAU - Chadwick, Paul
AU  - Chadwick P
FAU - Young, Duncan
AU  - Young D
FAU - Bentley, Andrew
AU  - Bentley A
FAU - Carlson, Gordon
AU  - Carlson G
FAU - Warhurst, Geoffrey
AU  - Warhurst G
LA  - eng
GR  - 08/13/16/DH_/Department of Health/United Kingdom
PT  - Journal Article
DEP - 20110630
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3191580
EDAT- 2011/10/25 06:00
MHDA- 2011/10/25 06:01
CRDT- 2011/10/25 06:00
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/10/25 06:00 [pubmed]
PHST- 2011/10/25 06:01 [medline]
AID - bmjopen-2011-000181 [pii]
AID - 10.1136/bmjopen-2011-000181 [doi]
PST - epublish
SO  - BMJ Open. 2011 Jun 30;1(1):e000181. doi: 10.1136/bmjopen-2011-000181.


PMID- 22021774
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 1
IP  - 1
DP  - 2011 Jun 17
TI  - Economic evaluation within a factorial-design randomised controlled trial of
      exercise, manual therapy, or both interventions for osteoarthritis of the hip or 
      knee: study protocol.
PG  - e000136
LID - 10.1136/bmjopen-2011-000136 [doi]
AB  - INTRODUCTION: Clinical guidelines for the treatment of hip and knee
      osteoarthritis recommend non-pharmacological and non-surgical treatments.
      Exercise treatments are recommended as primary strategies, but specific exercise 
      programme components have not been specified. Early evidence indicates that
      manual physiotherapy is effective for hip and knee osteoarthritis. The Management
      of Osteoarthritis (MOA) Trial was designed to evaluate the effectiveness and
      cost-effectiveness of physiotherapist-led, individualised exercise, manual
      physiotherapy and a combination of these two interventions in the treatment of
      adults with hip or knee osteoarthrits. This paper describes the methods that will
      be used to conduct the economic evaluation of these interventions within the MOA 
      Trial. METHODS AND ANALYSIS: This comprehensive economic evaluation will assess
      the incremental cost-effectiveness of physiotherapy plus usual care versus usual 
      care alone from a societal perspective. The authors will conduct a
      cost-consequences analysis using end-points such as Outcomes Measures in
      Rheumatology Clinical Trials-Osteoarthritis Research Society International
      responder criteria and quality-adjusted life years. The evaluation will have a
      time horizon of 1 year (and so discounting will not be necessary). All costs will
      be reported in 2009 New Zealand dollars. The authors will address uncertainty via
      bootstrapping to calculate CIs for the mean incremental cost-effectiveness ratios
      and by performing sensitivity analyses. ETHICS AND DISSEMINATION: Ethical
      approval was granted by the Lower South Regional Ethics Committee of the New
      Zealand Ministry of Health (ethics reference: LRS/07/11/044). All participants of
      the MOA Trial provided written informed consent for the capture of their
      healthcare costs. We will submit the results of the study for publication
      irrespective of outcome. Clinical trials registration number ACTRN12608000130369.
FAU - Pinto, Daniel
AU  - Pinto D
AD  - Centre for Physiotherapy Research, School of Physiotherapy, University of Otago, 
      Dunedin, New Zealand. daniel-pinto@northwestern.edu
FAU - Robertson, M Clare
AU  - Robertson MC
FAU - Hansen, Paul
AU  - Hansen P
FAU - Abbott, J Haxby
AU  - Abbott JH
CN  - MOA Trial Team
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110617
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3191427
EDAT- 2011/10/25 06:00
MHDA- 2011/10/25 06:01
CRDT- 2011/10/25 06:00
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/10/25 06:00 [pubmed]
PHST- 2011/10/25 06:01 [medline]
AID - bmjopen-2011-000136 [pii]
AID - 10.1136/bmjopen-2011-000136 [doi]
PST - epublish
SO  - BMJ Open. 2011 Jun 17;1(1):e000136. doi: 10.1136/bmjopen-2011-000136.


PMID- 22021769
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 1
IP  - 1
DP  - 2011 May 26
TI  - Detection and follow-up of cardiovascular disease and risk factors in the
      Southern Cone of Latin America: the CESCAS I study.
PG  - e000126
LID - 10.1136/bmjopen-2011-000126 [doi]
AB  - INTRODUCTION: Cardiovascular diseases (CVD) are increasing throughout the world
      and cause 16.7 million deaths each year, 80% of which occur in low and middle
      income countries. In Argentina, Chile and Uruguay, the available data on
      cardiovascular risk factors come predominantly from cross-sectional studies that 
      are principally based on self-report or studies conducted with small convenience 
      samples. The CESCAS I study will generate reliable estimates of the prevalence
      and distribution of and secular trends in CVD and its risk factors in this
      region. METHODS AND ANALYSIS: CESCAS I is an observational prospective cohort
      study with a multistage probabilistic sample of 8000 participants aged 35-74
      years from four mid-sized cities representing the Southern Cone of Latin America:
      Bariloche and Marcos Paz in Argentina, Temuco in Chile and Pando-Barros Blancos
      in Uruguay. In the first phase, baseline data regarding exposure to risk factors 
      and prevalence of CVD will be collected in two stages: (1) in homes and (2) in
      health centres. Information will be gathered on medical history, risk factors,
      lifestyles and health utilisation through specific questionnaires, physical
      measurements, an ECG and an overnight, fasting blood sample to measure levels of 
      serum lipids, glucose and creatinine. In the second phase, annual follow-up data 
      will be obtained on the incidence rate of CVD events and the association between 
      exposure and events. ETHICS AND DISSEMINATION: The protocol has obtained formal
      ethics approval from institutional review boards in Argentina, Chile, Uruguay and
      the USA. The lack of follow-up studies has prevented Argentina, Chile and Uruguay
      from implementing risk factor stratification and management strategies at a
      population level. However, the CESCAS I study data will help the development of
      public health strategies based on primary care intervention, thus helping to
      improve cardiovascular health in this region.
FAU - Rubinstein, Adolfo Luis
AU  - Rubinstein AL
AD  - Southern Cone American Center for Cardiovascular Health (CESCAS/SACECH),
      Institute for Clinical Effectiveness and Health Policy (IECS), Buenos Aires,
      Argentina. arubinstein@iecs.org.ar
FAU - Irazola, Vilma Edith
AU  - Irazola VE
FAU - Poggio, Rosana
AU  - Poggio R
FAU - Bazzano, Lydia
AU  - Bazzano L
FAU - Calandrelli, Matias
AU  - Calandrelli M
FAU - Lanas Zanetti, Fernando Tomas
AU  - Lanas Zanetti FT
FAU - Manfredi, Jose Anibal
AU  - Manfredi JA
FAU - Olivera, Hector
AU  - Olivera H
FAU - Seron, Pamela
AU  - Seron P
FAU - Ponzo, Jacqueline
AU  - Ponzo J
FAU - He, Jiang
AU  - He J
LA  - eng
GR  - HHSN268200900029C/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110526
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3191438
EDAT- 2011/10/25 06:00
MHDA- 2011/10/25 06:01
CRDT- 2011/10/25 06:00
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/10/25 06:00 [pubmed]
PHST- 2011/10/25 06:01 [medline]
AID - bmjopen-2011-000126 [pii]
AID - 10.1136/bmjopen-2011-000126 [doi]
PST - epublish
SO  - BMJ Open. 2011 May 26;1(1):e000126. doi: 10.1136/bmjopen-2011-000126.


PMID- 22021767
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 1
IP  - 1
DP  - 2011 Jul 22
TI  - Electrical modulation of the sympathetic nervous system in order to augment
      cerebral blood flow: a protocol for an experimental study.
PG  - e000120
LID - 10.1136/bmjopen-2011-000120 [doi]
AB  - Introduction Cerebral blood flow (CBF) is regulated by several mechanisms.
      Neurogenic control has been a matter of debate, even though several publications 
      reported the effects of changes in sympathetic tone on CBF. Transcutaneous
      electrical nerve stimulation and spinal-cord stimulation have been shown to
      influence peripheral and cerebral blood flow through a sympathetic pathway. The
      authors hypothesise that certain pathological conditions result in a relative
      increase in the neurogenic regulation of CBF and that this regulation can be
      modulated electrically. Methods and analysis Patients with cerebral vasospasm
      after subarachnoid haemorrhage will be included. The experimental set-up measures
      several parameters that are involved in cerebral blood flow regulation in
      patients with cerebral vasospasm after subarachnoid haemorrhage. Measurements are
      taken at baseline and with stimulation in several frequencies. An ad hoc
      statistical analysis is used to evaluate different settings of the electrical
      stimulation. Autoregulation is evaluated with transfer function analysis and
      autoregulatory index calculations. Ethics and dissemination Ethical registration 
      was granted by Medical Review Ethics Committee Groningen (ID METc 2010.123). All 
      participants provide written informed consent on participation. Upon finishing a 
      pilot study to investigate feasibility and effect, either future prospective
      (randomised) studies will be designed, or other modalities of electrical
      stimulation will be explored using the same set-up. Trial Registration Dutch
      Trial Registry: NTR2358.
FAU - Ter Laan, Mark
AU  - Ter Laan M
AD  - Department of Neurosurgery, University Medical Center Groningen, Groningen, The
      Netherlands.
FAU - van Dijk, J Marc C
AU  - van Dijk JM
FAU - Staal, Michiel J
AU  - Staal MJ
FAU - Elting, Jan-Willem J
AU  - Elting JW
LA  - eng
PT  - Journal Article
DEP - 20110722
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3191412
EDAT- 2011/10/25 06:00
MHDA- 2011/10/25 06:01
CRDT- 2011/10/25 06:00
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/10/25 06:00 [pubmed]
PHST- 2011/10/25 06:01 [medline]
AID - bmjopen-2011-000120 [pii]
AID - 10.1136/bmjopen-2011-000120 [doi]
PST - epublish
SO  - BMJ Open. 2011 Jul 22;1(1):e000120. doi: 10.1136/bmjopen-2011-000120.


PMID- 22021763
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 1
IP  - 1
DP  - 2011 Apr 7
TI  - Projecting prevalence by stage of care for prostate cancer and estimating future 
      health service needs: protocol for a modelling study.
PG  - e000104
LID - 10.1136/bmjopen-2011-000104 [doi]
AB  - Introduction Current strategies for the management of prostate cancer are
      inadequate in Australia. We will, in this study, estimate current service needs
      and project the future needs for prostate cancer patients in Australia. Methods
      and analysis First, we will project the future prevalence of prostate cancer for 
      2010-2018 using data for 1972-2008 from the New South Wales (NSW) Central Cancer 
      Registry. These projections, based on modelled incidence and survival estimates, 
      will be estimated using PIAMOD (Prevalence, Incidence, Analysis MODel) software. 
      Then the total prevalence will be decomposed into five stages of care: initial
      care, continued monitoring, recurrence, last year of life and long-term survivor.
      Finally, data from the NSW Prostate Cancer Care and Outcomes Study, including
      data on patterns of treatment and associated quality of life, will be used to
      estimate the type and amount of services that will be needed by prostate cancer
      patients in each stage of care. In addition, Central Cancer Registry episode data
      will be used to estimate transition rates from localised or locally advanced
      prostate cancer to metastatic disease. Medicare and Pharmaceutical Benefits data,
      linked with Prostate Cancer Care and Outcomes Study data, will be used to
      complement the Cancer Registry episode data. The methods developed will be
      applied Australia-wide to obtain national estimates of the future prevalence of
      prostate cancer for different stages of clinical care. Ethics and dissemination
      This study was approved by the NSW Population and Health Services Research Ethics
      Committee. Results of the study will be disseminated widely to different interest
      groups and organisations through a report, conference presentations and
      peer-reviewed articles.
FAU - Yu, Xue Q
AU  - Yu XQ
AD  - Cancer Epidemiology Research Unit, Cancer Council New South Wales, Sydney,
      Australia.
FAU - Smith, David P
AU  - Smith DP
FAU - Clements, Mark S
AU  - Clements MS
FAU - Patel, Manish I
AU  - Patel MI
FAU - McHugh, Bill
AU  - McHugh B
FAU - O'Connell, Dianne L
AU  - O'Connell DL
LA  - eng
PT  - Journal Article
DEP - 20110407
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3191396
EDAT- 2011/10/25 06:00
MHDA- 2011/10/25 06:01
CRDT- 2011/10/25 06:00
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/10/25 06:00 [pubmed]
PHST- 2011/10/25 06:01 [medline]
AID - bmjopen-2011-000104 [pii]
AID - 10.1136/bmjopen-2011-000104 [doi]
PST - epublish
SO  - BMJ Open. 2011 Apr 7;1(1):e000104. doi: 10.1136/bmjopen-2011-000104.


PMID- 22021738
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 1
IP  - 1
DP  - 2011 Feb 23
TI  - A randomised controlled trial of cognitive-behavioural therapy for women with
      problematic menopausal hot flushes: MENOS 2 trial protocol.
PG  - e000047
LID - 10.1136/bmjopen-2010-000047 [doi]
AB  - OBJECTIVES: Hot flushes and night sweats (HF/NS) are experienced by 60-70% of
      menopausal women and are problematic for approximately 20-25%. Potential health
      risks associated with hormone-replacement therapy (HT) have led to a significant 
      decline in HT use. There is therefore a need for safe, effective and
      evidence-based alternative treatments for menopausal symptoms. Previous
      exploratory work suggests that cognitive-behavioural therapy (CBT) is acceptable 
      and effective for women with HF/NS during natural menopause and following
      breast-cancer treatment. This randomised controlled trial compares the
      effectiveness of Group CBT and Guided Self-Help CBT with no treatment control in 
      reducing HF/NS Problem Rating and Frequency at post-treatment (main outcome) and 
      at 6 months postrandomisation. METHODS AND ANALYSIS: 120 women, with 10 or more
      HF/NS a week for a month, are recruited from GP surgeries and the local community
      of South London. They are randomised to either 4 weeks of Group CBT, 4 weeks
      guided Self-Help CBT or no treatment control. Participants attend a clinical
      interview, and complete baseline questionnaire measures of HF/NS Problem Rating
      and Frequency (primary outcomes), mood, quality of life, self-esteem, hot-flush
      beliefs and behaviours, optimism and somatic amplification, and undergo 24 h
      sternal skin conductance monitoring (SCC-physiological measure of HF/NS)
      (secondary outcomes). Post-treatment measures (SSC, questionnaires and use of
      medical services) are collected 6-8 weeks later and follow-up measures
      (questionnaires and a use of medical services measure) at 6 months
      postrandomisation. ETHICS AND DISSEMINATION: Ethical registration was granted by 
      King's College London Research Ethics Committee (ref: PNM/08/09-42). All
      participants provide written informed consent. If treatment is successful, a
      Group CBT training manual and training sessions for health professionals, and a
      Self-Help CBT book will be published. Other CBT delivery options will also be
      examined (including Computerised Self-Help CBT and Group CBT workshops). Clinical
      Trial Registration Number ISRCTN57302613.
FAU - Ayers, Beverley
AU  - Ayers B
AD  - Department of Psychology (at Guy's), Institute of Psychiatry, King's College
      London, London, UK.
FAU - Mann, Eleanor
AU  - Mann E
FAU - Hunter, Myra S
AU  - Hunter MS
LA  - eng
SI  - ISRCTN/ISRCTN57302613
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110223
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3191497
EDAT- 2011/10/25 06:00
MHDA- 2011/10/25 06:01
CRDT- 2011/10/25 06:00
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/10/25 06:00 [pubmed]
PHST- 2011/10/25 06:01 [medline]
AID - bmjopen-2010-000047 [pii]
AID - 10.1136/bmjopen-2010-000047 [doi]
PST - epublish
SO  - BMJ Open. 2011 Feb 23;1(1):e000047. doi: 10.1136/bmjopen-2010-000047.


PMID- 22021722
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 1
IP  - 1
DP  - 2011 Feb 23
TI  - The NOTA study: non-operative treatment for acute appendicitis: prospective study
      on the efficacy and safety of antibiotic treatment (amoxicillin and clavulanic
      acid) in patients with right sided lower abdominal pain.
PG  - e000006
LID - 10.1136/bmjopen-2010-000006 [doi]
AB  - BACKGROUND: Case control studies that randomly assign patients with diagnosis of 
      acute appendicitis to either surgical or non-surgical treatment yield a relapse
      rate of approximately 14% at one year. It would be useful to know the relapse
      rate of patients who have, instead, been selected for a given treatment based on 
      a thorough clinical evaluation, including physical examination and laboratory
      results (Alvarado Score) as well as radiological exams if needed or deemed
      helpful. If this clinical evaluation is useful, the investigators would expect
      patient selection to be better than chance, and relapse rate to be lower than
      14%. Once the investigators have established the utility of this evaluation, the 
      investigators can begin to identify those components that have predictive value
      (such as blood analysis, or US/CT findings). This is the first step toward
      developing an accurate diagnostic-therapeutic algorithm which will avoid risks
      and costs of needless surgery. METHODS/DESIGN: This will be a single-cohort
      prospective observational study. It will not interfere with the usual pathway,
      consisting of clinical examination in the Emergency Department (ED) and execution
      of the following exams at the physician's discretion: full blood count with
      differential, C reactive protein, abdominal ultrasound, abdominal CT. Patients
      admitted to an ED with lower abdominal pain and suspicion of acute appendicitis
      and not needing immediate surgery, are requested by informed consent to undergo
      observation and non operative treatment with antibiotic therapy (Amoxicillin and 
      Clavulanic Acid). The patients by protocol should not have received any previous 
      antibiotic treatment during the same clinical episode. Patients not undergoing
      surgery will be physically examined 5 days later. Further follow-up will be
      conducted at 7, 15 days, 6 months and 12 months. The study will conform to
      clinical practice guidelines and will follow the recommendations of the
      Declaration of Helsinki. The protocol was approved on November 2009 by Maggiore
      Hospital Ethical Review Board (ID CE09079). Trial Registration ClinicalTrials.gov
      identifier: NCT01096927.
FAU - Tugnoli, Gregorio
AU  - Tugnoli G
AD  - Department of Emergency, Emergency Surgery and Trauma Surgery Unit, Trauma
      Center, Maggiore Hospital - Bologna Local Health District, Bologna, Italy.
FAU - Giorgini, Eleonora
AU  - Giorgini E
FAU - Biscardi, Andrea
AU  - Biscardi A
FAU - Villani, Silvia
AU  - Villani S
FAU - Clemente, Nicola
AU  - Clemente N
FAU - Senatore, Gianluca
AU  - Senatore G
FAU - Filicori, Filippo
AU  - Filicori F
FAU - Antonacci, Nicola
AU  - Antonacci N
FAU - Baldoni, Franco
AU  - Baldoni F
FAU - De Werra, Carlo
AU  - De Werra C
FAU - Di Saverio, Salomone
AU  - Di Saverio S
LA  - eng
SI  - ClinicalTrials.gov/NCT01096927
PT  - Journal Article
DEP - 20110223
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3191386
EDAT- 2011/10/25 06:00
MHDA- 2011/10/25 06:01
CRDT- 2011/10/25 06:00
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/10/25 06:00 [pubmed]
PHST- 2011/10/25 06:01 [medline]
AID - bmjopen-2010-000006 [pii]
AID - 10.1136/bmjopen-2010-000006 [doi]
PST - epublish
SO  - BMJ Open. 2011 Feb 23;1(1):e000006. doi: 10.1136/bmjopen-2010-000006.


PMID- 22021687
OWN - NLM
STAT- MEDLINE
DCOM- 20120301
LR  - 20111024
IS  - 1791-7549 (Electronic)
IS  - 0258-851X (Linking)
VI  - 25
IP  - 6
DP  - 2011 Nov-Dec
TI  - Offspring after embryo-preserving biopsy of the embryoblast with standard ICSI
      equipment in mouse blastocysts.
PG  - 935-9
AB  - BACKGROUND/AIM: Obtaining human embryonic stem cell lines has so far involved
      destroying the embryos. This has given rise to ethical concerns and is not
      permitted in most countries. This investigation tested whether removing multiple 
      cells from blastocysts might allow continued embryonic development. MATERIALS AND
      METHODS: A total of 40 blastocysts from a black mouse strain were biopsied. The
      mouse blastocysts were fixed with a holding pipette. The zona pellucida and
      trophectoderm layer were penetrated with an injection pipette, and cells from the
      inner cell mass (ICM) were aspirated. The pipette was removed and the ICM cells
      were transferred into a medium. RESULTS: The blastocysts collapsed after pipette 
      removal and were allowed to regenerate for 6 h. Twenty-four blastocysts
      recovered, expanded and were implanted into four white surrogate mothers. One
      surrogate mother gave birth to two black pups. CONCLUSION: This experiment
      demonstrates that nondestructive blastocyst biopsy from the ICM is possible in
      mice.
FAU - Dittrich, Ralf
AU  - Dittrich R
AD  - Department of Obstetrics and Gynecology, Erlangen University Hospital, University
      of Erlangen-Nuremberg, Universitaetsstrasse 21-23, D-91054 Erlangen, Germany.
      ralf.dittrich@uk-erlangen.de
FAU - Lotz, Laura
AU  - Lotz L
FAU - Wurfel, Wolfgang
AU  - Wurfel W
FAU - Engelkamp, Dieter
AU  - Engelkamp D
FAU - Dohler, Martina
AU  - Dohler M
FAU - Maltaris, Theodoros
AU  - Maltaris T
FAU - Hoffmann, Inge
AU  - Hoffmann I
FAU - Mueller, Andreas
AU  - Mueller A
FAU - Beckmann, Matthias W
AU  - Beckmann MW
FAU - Oppelt, Patricia G
AU  - Oppelt PG
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - In Vivo
JT  - In vivo (Athens, Greece)
JID - 8806809
RN  - 0 (Culture Media)
SB  - IM
MH  - Animals
MH  - Biopsy
MH  - Blastocyst/*cytology
MH  - Culture Media
MH  - *Embryo, Mammalian
MH  - Female
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - *Sperm Injections, Intracytoplasmic/instrumentation
EDAT- 2011/10/25 06:00
MHDA- 2012/03/02 06:00
CRDT- 2011/10/25 06:00
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/10/25 06:00 [pubmed]
PHST- 2012/03/02 06:00 [medline]
AID - 25/6/935 [pii]
PST - ppublish
SO  - In Vivo. 2011 Nov-Dec;25(6):935-9.


PMID- 22021290
OWN - NLM
STAT- MEDLINE
DCOM- 20111229
LR  - 20211020
IS  - 1541-0048 (Electronic)
IS  - 0090-0036 (Linking)
VI  - 101
IP  - 12
DP  - 2011 Dec
TI  - An innovative method to involve community health workers as partners in
      evaluation research.
PG  - 2275-80
LID - 10.2105/AJPH.2011.300263 [doi]
AB  - OBJECTIVES: We developed a process through which community outreach workers,
      whose role is not typically that of a trained researcher, could actively
      participate in collection of qualitative evaluation data. METHODS: Outreach
      workers for a community-based intervention project received training in
      qualitative research methodology and certification in research ethics. They used 
      a Voice over Internet Protocol phone-in system to provide narrative reports about
      challenges faced by women they encountered in their outreach activities as well
      as their own experiences as outreach workers. RESULTS: Qualitative data
      contributed by outreach workers provided insights not otherwise available to the 
      evaluation team, including details about the complex lives of underserved women
      at risk for poor pregnancy outcomes and the challenges and rewards of the
      outreach worker role. CONCLUSIONS: Lay health workers can be a valuable asset as 
      part of a research team. Training in research ethics and methods can be tailored 
      to their educational level and preferences, and their insights provide important 
      information and perspectives that may not be accessible via other data collection
      methods. Challenges encountered in the dual roles of researcher and lay health
      worker can be addressed in training.
FAU - Peacock, Nadine
AU  - Peacock N
AD  - School of Public Health, University of Illinois at Chicago, 60612, USA.
      npeacock@uic.edu
FAU - Issel, L Michele
AU  - Issel LM
FAU - Townsell, Stephanie J
AU  - Townsell SJ
FAU - Chapple-McGruder, Theresa
AU  - Chapple-McGruder T
FAU - Handler, Arden
AU  - Handler A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111020
PL  - United States
TA  - Am J Public Health
JT  - American journal of public health
JID - 1254074
SB  - IM
MH  - African Americans
MH  - Community Health Workers/*education/psychology
MH  - *Community-Based Participatory Research
MH  - *Data Collection
MH  - Ethics, Research/education
MH  - Female
MH  - Humans
MH  - Poverty
MH  - Pregnancy
MH  - Prenatal Care
MH  - *Qualitative Research
PMC - PMC3222420
EDAT- 2011/10/25 06:00
MHDA- 2011/12/30 06:00
CRDT- 2011/10/25 06:00
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/10/25 06:00 [pubmed]
PHST- 2011/12/30 06:00 [medline]
AID - AJPH.2011.300263 [pii]
AID - 10.2105/AJPH.2011.300263 [doi]
PST - ppublish
SO  - Am J Public Health. 2011 Dec;101(12):2275-80. doi: 10.2105/AJPH.2011.300263. Epub
      2011 Oct 20.


PMID- 22021275
OWN - NLM
STAT- MEDLINE
DCOM- 20121016
LR  - 20211020
IS  - 1461-7277 (Electronic)
IS  - 1359-1053 (Linking)
VI  - 17
IP  - 5
DP  - 2012 Jul
TI  - Conceptualizing the role of research literacy in advancing societal health.
PG  - 724-30
LID - 10.1177/1359105311425273 [doi]
AB  - 'Research literacy' is proposed as a key concept for advancing societal health.
      To examine whether improvements in research literacy would affect knowledge of
      and ethical participation in research, parents of young children received a brief
      educational intervention designed to enhance their understanding of child
      research. Results demonstrated that the intervention improved research-related
      knowledge and increased parents' comfort with their research participation
      decisions. Moreover, enhanced understanding of child volition increased parents' 
      willingness to enrol their children in research. The proposed research literacy
      model identifies methods to enhance population knowledge and appreciation of
      research, strengthening links between scientific advancement and health.
FAU - Brody, Janet L
AU  - Brody JL
AD  - Oregon Research Institute, Center for Family and Adolescent Research, USA.
      jbrody@ori.org
FAU - Dalen, Jeanne
AU  - Dalen J
FAU - Annett, Robert D
AU  - Annett RD
FAU - Scherer, David G
AU  - Scherer DG
FAU - Turner, Charles W
AU  - Turner CW
LA  - eng
GR  - R01 HL064677/HL/NHLBI NIH HHS/United States
GR  - R01 HL64677/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20111021
PL  - England
TA  - J Health Psychol
JT  - Journal of health psychology
JID - 9703616
SB  - IM
MH  - Adult
MH  - *Biomedical Research
MH  - Child
MH  - *Concept Formation
MH  - Decision Making
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - *Health Literacy
MH  - Humans
MH  - Male
MH  - Parents/*education
MH  - *Patient Participation
MH  - Pediatrics
MH  - Surveys and Questionnaires
MH  - United States
PMC - PMC3643813
MID - NIHMS460001
EDAT- 2011/10/25 06:00
MHDA- 2012/10/17 06:00
CRDT- 2011/10/25 06:00
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/10/25 06:00 [pubmed]
PHST- 2012/10/17 06:00 [medline]
AID - 1359105311425273 [pii]
AID - 10.1177/1359105311425273 [doi]
PST - ppublish
SO  - J Health Psychol. 2012 Jul;17(5):724-30. doi: 10.1177/1359105311425273. Epub 2011
      Oct 21.


PMID- 22020691
OWN - NLM
STAT- MEDLINE
DCOM- 20120412
LR  - 20111024
IS  - 1439-359X (Electronic)
IS  - 0939-7248 (Linking)
VI  - 21
IP  - 5
DP  - 2011 Oct
TI  - Flexible-tip laparo-endoscopic surgery: a bridge to single port appendicectomy in
      children.
PG  - 322-4
LID - 10.1055/s-0031-1283163 [doi]
AB  - INTRODUCTION: Single port surgery (SPS) has been demonstrated to have some
      advantages over conventional laparoscopy. However, currently available port sizes
      may limit the application in younger children or those with a small umbilicus.
      Moreover, the consultant learning curve required to master single port surgery
      may have a negative impact on surgical training. We report the first series of
      children who were treated with a reduced incision technique for appendicectomy
      using flexible-tip laparo-endoscopic surgery (FLES). PATIENTS AND METHODS: FLES
      was set up using one 11-mm and 2 x 5-mm bladeless ports (Ethicon XCEL) via
      umbilical and low left iliac fossa incisions. A 10-mm flexible-tip
      laparo-endoscope was utilized. Tip angulation ensured visibility while minimising
      instrument clashing. A database of children undergoing FLES was kept
      prospectively. Demographic and peri-operative information and complications were 
      recorded. Data are presented as medians with ranges. RESULTS: Between March and
      June 2010, 5 children (4 females) aged 9 (4-13) years underwent FLES for right
      iliac fossa pain. 2 procedures were performed by the admitting consultant, 3 by a
      supervised inexperienced laparoscopic trainee. 4 children had acute appendicitis 
      including 1 with an inflammatory mass. Another had a haemorrhagic ovarian cyst.
      Appendicectomy was performed in all. The duration of surgery was 104 (93-130)
      min, and postoperative hospital stay was 2 (1-6) days. At 7 (5-8) months'
      follow-up no complications have been recorded. At follow-up, the cosmetic results
      were judged to be excellent in all by the children, their parents and the
      reviewing surgeon. CONCLUSIONS: FLES is an alternative to standard laparoscopy
      and SPS in children, and be performed effectively and safely by junior trainees. 
      Cosmetic results are excellent. It may represent a bridge technology,
      particularly for younger children, until single port products and techniques more
      suitable for appendicectomy in this age group are available. Finally,
      flexible-tip technology may play a useful role as SPS evolves.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Zani, A
AU  - Zani A
AD  - Department of Paediatric Surgery, K ing's College Hospital, London, U nited
      Kingdom.
FAU - Ade-Ajayi, N
AU  - Ade-Ajayi N
LA  - eng
PT  - Journal Article
DEP - 20111021
PL  - United States
TA  - Eur J Pediatr Surg
JT  - European journal of pediatric surgery : official journal of Austrian Association 
      of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie
JID - 9105263
SB  - IM
MH  - Adolescent
MH  - Appendectomy/instrumentation/*methods
MH  - Appendicitis/*surgery
MH  - Child
MH  - Female
MH  - Humans
MH  - Laparoscopes
MH  - Laparoscopy/instrumentation/*methods
MH  - Male
MH  - Ovarian Cysts/*surgery
EDAT- 2011/10/25 06:00
MHDA- 2012/04/13 06:00
CRDT- 2011/10/25 06:00
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/10/25 06:00 [pubmed]
PHST- 2012/04/13 06:00 [medline]
AID - 10.1055/s-0031-1283163 [doi]
PST - ppublish
SO  - Eur J Pediatr Surg. 2011 Oct;21(5):322-4. doi: 10.1055/s-0031-1283163. Epub 2011 
      Oct 21.


PMID- 22020345
OWN - NLM
STAT- MEDLINE
DCOM- 20120410
LR  - 20211020
IS  - 1573-2622 (Electronic)
IS  - 0012-4486 (Linking)
VI  - 123
IP  - 3
DP  - 2011 Dec
TI  - Investigation of the temporal properties of the retina using the m-sequence.
PG  - 179-85
LID - 10.1007/s10633-011-9295-9 [doi]
AB  - The mfERG provides a topographic map of function of the retina and has been used 
      in numerous studies to identify macular, paramacular and peripheral retinal
      dysfunction. This study investigates the changes in response due to the
      presentation rate of the stimulus. Twenty subjects gave informed consent to take 
      part in the study, which had local regional ethical committee approval. Only a
      single hexagon of 8 degrees diameter was presented to reduce ambiguity when
      identifying the higher-order kernels (HOK). Six rates were tested using a 60-Hz
      CRT monitor by introducing blank (black ~0 cd/m2) filler frames (FF). The rates
      tested were 0FF; 1FF; 2FF; 4FF; 7FF; and 14FF. The first-order kernel had largest
      responses to the slower stimuli (4FF and above). HOK had largest amplitudes at
      faster rates with the second-order kernel peaking at 1FF. At rates with 4FF and
      slower, the higher-order kernels were indiscernible above the noise.
FAU - Hagan, Richard P
AU  - Hagan RP
AD  - Department of Medical Physics and Clinical Engineering, Royal Liverpool
      University Hospital, Prescot Street, Liverpool, L7 8XP, UK. r.p.hagan@liv.ac.uk
FAU - Fisher, Anthony C
AU  - Fisher AC
FAU - Brown, Malcolm C
AU  - Brown MC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20111022
PL  - Netherlands
TA  - Doc Ophthalmol
JT  - Documenta ophthalmologica. Advances in ophthalmology
JID - 0370667
SB  - IM
MH  - Adult
MH  - Electroretinography/*methods
MH  - Humans
MH  - Male
MH  - Photic Stimulation
MH  - Reference Values
MH  - Retina/*physiology
MH  - Young Adult
EDAT- 2011/10/25 06:00
MHDA- 2012/04/11 06:00
CRDT- 2011/10/25 06:00
PHST- 2011/02/09 00:00 [received]
PHST- 2011/10/10 00:00 [accepted]
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/10/25 06:00 [pubmed]
PHST- 2012/04/11 06:00 [medline]
AID - 10.1007/s10633-011-9295-9 [doi]
PST - ppublish
SO  - Doc Ophthalmol. 2011 Dec;123(3):179-85. doi: 10.1007/s10633-011-9295-9. Epub 2011
      Oct 22.


PMID- 22019616
OWN - NLM
STAT- MEDLINE
DCOM- 20120928
LR  - 20220408
IS  - 1472-6491 (Electronic)
IS  - 1472-6483 (Linking)
VI  - 23
IP  - 7
DP  - 2011 Dec
TI  - Social egg freezing: for better, not for worse.
PG  - 824-9
LID - 10.1016/j.rbmo.2011.09.010 [doi]
AB  - The possibility for healthy women to cryopreserve their oocytes in order to
      counter future infertility has gained momentum in recent years. However, women
      tend to cryopreserve oocytes at an age that is suboptimal from a clinical point
      of view--in their late thirties--when both oocyte quantity and quality have
      already considerably diminished and success rates for eventually establishing a
      pregnancy are thus limited. This also gives rise to ethical concerns, as the
      procedure is seen as giving false hope to (reproductively speaking) older women. 
      This study evaluates which measures can be taken to turn social freezing into a
      procedure that is both clinically and ethically better than the current practice.
      The main objective of these measures is to convince those women who are most
      likely to (want to) reproduce at an above-average age to cryopreserve their
      oocytes at a time when this intervention is still likely to lead to a live birth 
      and to discourage fertility clinics from specifically targeting women who have
      already surpassed the age at which good results can be expected. The possibility 
      for healthy women to cryopreserve their oocytes in order to counter future
      infertility has gained momentum in recent years. However, women tend to
      cryopreserve oocytes at a time that is suboptimal from a clinical point of view -
      in their late thirties - when both oocyte quantity and quality have already
      considerably diminished and success rates for eventually establishing a pregnancy
      are thus limited. This also gives rise to ethical concerns, as the procedure is
      seen as giving false hope to (reproductively speaking) older women. We evaluate
      which measures can be taken to turn social freezing into a procedure that is both
      clinically and ethically better than the current practice and discern three
      different steps: creating public awareness; offering individualized, age-specific
      information and counselling; and offering predictive tests such as anti-Mullerian
      hormone measurements or antral follicle count. The main objective of these
      measures is to convince those women who are most likely to benefit from social
      freezing to present themselves before age 35 and to discourage fertility clinics 
      from specifically targeting women who have already surpassed the age at which
      good results can be expected.
CI  - Copyright (c) 2011 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All
      rights reserved.
FAU - Mertes, Heidi
AU  - Mertes H
AD  - Bioethics Institute Ghent, Blandijnberg 2, Gent, Belgium. Heidi.Mertes@UGent.be
FAU - Pennings, Guido
AU  - Pennings G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110929
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Cryopreservation/*ethics
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - *Oocytes
MH  - Reproductive Techniques, Assisted/*ethics/psychology
EDAT- 2011/10/25 06:00
MHDA- 2012/09/29 06:00
CRDT- 2011/10/25 06:00
PHST- 2011/05/23 00:00 [received]
PHST- 2011/08/08 00:00 [revised]
PHST- 2011/09/19 00:00 [accepted]
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/10/25 06:00 [pubmed]
PHST- 2012/09/29 06:00 [medline]
AID - S1472-6483(11)00517-7 [pii]
AID - 10.1016/j.rbmo.2011.09.010 [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2011 Dec;23(7):824-9. doi: 10.1016/j.rbmo.2011.09.010. Epub
      2011 Sep 29.


PMID- 22019535
OWN - NLM
STAT- MEDLINE
DCOM- 20120228
LR  - 20111024
IS  - 1529-8795 (Electronic)
IS  - 0031-5982 (Linking)
VI  - 54
IP  - 4
DP  - 2011 Autumn
TI  - Reflections on the history and ethics of the proper attribution and
      misappropriation of merit.
PG  - 470-8
LID - 10.1353/pbm.2011.0038 [doi]
AB  - One would expect that the first to arrive at a new observation, discovery, or
      concept would be properly acknowledged as such. Unfortunately, it is not unusual 
      that someone else receives the credit. This is not just unfair and unethical, but
      it also distorts the history of science. In addition, the victims of
      misattribution are deeply affected by losing not only the recognition of being
      first, but also the credit, kudos, and other benefits that derive from their
      contribution. This issue deserves far more attention than it currently receives. 
      It continues to cause much mischief in the most unexpected places and under
      circumstances that should not be tolerated. This article looks at the
      consequences of some instances of misattribution in the history of science and
      argues that researchers should make a stronger effort to expose and rectify such 
      cases. In most instances, all that is required is to double-check the data.
FAU - Gans, Henry
AU  - Gans H
AD  - University of Illinois College of Clinical Medicine, Urbana/Champaign, IL, USA.
      gans4550@comcast.net
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - Perspect Biol Med
JT  - Perspectives in biology and medicine
JID - 0401132
SB  - IM
MH  - Awards and Prizes
MH  - *Ethics, Research
MH  - History, 18th Century
MH  - History, 19th Century
MH  - History, 20th Century
MH  - Humans
MH  - Science/*history
EDAT- 2011/10/25 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/10/25 06:00
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/10/25 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - S1529879511400077 [pii]
AID - 10.1353/pbm.2011.0038 [doi]
PST - ppublish
SO  - Perspect Biol Med. 2011 Autumn;54(4):470-8. doi: 10.1353/pbm.2011.0038.


PMID- 22019534
OWN - NLM
STAT- MEDLINE
DCOM- 20120228
LR  - 20111024
IS  - 1529-8795 (Electronic)
IS  - 0031-5982 (Linking)
VI  - 54
IP  - 4
DP  - 2011 Autumn
TI  - Medical professionalism and the social contract.
PG  - 455-69
LID - 10.1353/pbm.2011.0048 [doi]
AB  - Conceptions of professionalism in medicine draw on social contract theory; its
      strengths and weaknesses play out in how we reason about professionalism. The
      social contract metaphor may be a heuristic device prompting reflection on social
      responsibility, and as such is appealing: it encourages reasoning about privilege
      and responsibility, the broader context and consequences of action, and diverse
      perspectives on medical practice. However, when this metaphor is elevated to the 
      status of a theory, it has well-known limits: the assumed subject position of
      contractors engenders blind spots about privilege, not critical reflection; its
      tendency to dress up the status quo in the trappings of a theoretical agreement
      may limit social negotiation; its attempted reconciliation of social obligation
      and self-interest fosters the view that ethics and self-interest should coincide;
      it sets up false expectations by identifying appearance and reality in morality; 
      and its construal of prima facie duties as conditional misdirects ethical
      attention in particular situations from current needs to supposed past agreements
      or reciprocities. Using philosophical ideas as heuristic devices in medical
      ethics is inevitable, but we should be conscious of their limitations. When they 
      limit the ethical scope of debate, we should seek new metaphors.
FAU - Reid, Lynette
AU  - Reid L
AD  - Department of Bioethics, Faculty of Medicine, Dalhousie University, P.O. Box
      15000, 5849 University Avenue, Halifax, NS B3H 4R2, Canada. Lynette.Reid@dal.ca
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Perspect Biol Med
JT  - Perspectives in biology and medicine
JID - 0401132
SB  - IM
MH  - *Clinical Competence
MH  - Humans
MH  - Metaphor
MH  - Morals
MH  - *Physician's Role
MH  - *Social Responsibility
EDAT- 2011/10/25 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/10/25 06:00
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/10/25 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - S1529879511400065 [pii]
AID - 10.1353/pbm.2011.0048 [doi]
PST - ppublish
SO  - Perspect Biol Med. 2011 Autumn;54(4):455-69. doi: 10.1353/pbm.2011.0048.


PMID- 22019125
OWN - NLM
STAT- MEDLINE
DCOM- 20120123
LR  - 20111201
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 96
IP  - 6
DP  - 2011 Dec
TI  - Disclosure of medical errors involving gametes and embryos.
PG  - 1312-4
LID - 10.1016/j.fertnstert.2011.09.019 [doi]
AB  - Medical providers have an ethical duty to immediately disclose clinical errors
      involving gametes or embryos; clinics should have written policies in place for
      reducing and disclosing errors. This document was reviewed and affirmed in 2011
      and replaces the earlier document of the same name.
CI  - Copyright (c) 2011 American Society for Reproductive Medicine. Published by
      Elsevier Inc. All rights reserved.
CN  - Ethics Committee of the American Society for Reproductive Medicine
AD  - American Society for Reproductive Medicine, Birmingham, Alabama, USA.
LA  - eng
PT  - Journal Article
PT  - Practice Guideline
DEP - 20111022
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
SB  - IM
MH  - Directed Tissue Donation/ethics/legislation & jurisprudence
MH  - *Disclosure/ethics/legislation & jurisprudence
MH  - Embryo Transfer/ethics
MH  - *Embryo, Mammalian/cytology
MH  - Female
MH  - *Germ Cells/cytology
MH  - Humans
MH  - Infertility/*therapy
MH  - Male
MH  - Medical Errors/*ethics/legislation & jurisprudence
MH  - Reproductive Techniques, Assisted/*ethics/legislation & jurisprudence
MH  - Truth Disclosure/ethics
IR  - Brzyski R
FIR - Brzyski, Robert
IR  - Braverman A
FIR - Braverman, Andrea
IR  - Stein A
FIR - Stein, Andrea
IR  - Steinbock B
FIR - Steinbock, Bonnie
IR  - Wilder B
FIR - Wilder, Bruce
IR  - Lamb D
FIR - Lamb, Dolores
IR  - Robertson J
FIR - Robertson, John
IR  - Daar J
FIR - Daar, Judith
IR  - Francis L
FIR - Francis, Leslie
IR  - Gibson M
FIR - Gibson, Mark
IR  - Rebar R
FIR - Rebar, Robert
IR  - Rhodes R
FIR - Rhodes, Rosamond
IR  - Tipton S
FIR - Tipton, Sean
IR  - Fisseha S
FIR - Fisseha, Senait
IR  - Ralston S
FIR - Ralston, Steven
EDAT- 2011/10/25 06:00
MHDA- 2012/01/24 06:00
CRDT- 2011/10/25 06:00
PHST- 2011/09/06 00:00 [received]
PHST- 2011/09/08 00:00 [accepted]
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/10/25 06:00 [pubmed]
PHST- 2012/01/24 06:00 [medline]
AID - S0015-0282(11)02547-7 [pii]
AID - 10.1016/j.fertnstert.2011.09.019 [doi]
PST - ppublish
SO  - Fertil Steril. 2011 Dec;96(6):1312-4. doi: 10.1016/j.fertnstert.2011.09.019. Epub
      2011 Oct 22.


PMID- 22019061
OWN - NLM
STAT- MEDLINE
DCOM- 20120813
LR  - 20211020
IS  - 1578-1275 (Electronic)
IS  - 0212-6567 (Linking)
VI  - 44
IP  - 4
DP  - 2012 Apr
TI  - [Signing the death certificate: legality and ethics].
PG  - e20-2
LID - 10.1016/j.aprim.2011.07.012 [doi]
FAU - Monso i Fernandez, Carles
AU  - Monso i Fernandez C
LA  - spa
PT  - Letter
TT  - inverted question markFirmo el certificado de defuncion? Legalidad y etica.
DEP - 20111021
PL  - Spain
TA  - Aten Primaria
JT  - Atencion primaria
JID - 9111075
SB  - IM
MH  - Algorithms
MH  - *Bioethical Issues
MH  - Cause of Death
MH  - Death Certificates/*legislation & jurisprudence
MH  - *Ethics, Medical
MH  - Humans
PMC - PMC7025232
EDAT- 2011/10/25 06:00
MHDA- 2012/08/14 06:00
CRDT- 2011/10/25 06:00
PHST- 2011/06/23 00:00 [received]
PHST- 2011/07/17 00:00 [accepted]
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/10/25 06:00 [pubmed]
PHST- 2012/08/14 06:00 [medline]
AID - S0212-6567(11)00427-6 [pii]
AID - 10.1016/j.aprim.2011.07.012 [doi]
PST - ppublish
SO  - Aten Primaria. 2012 Apr;44(4):e20-2. doi: 10.1016/j.aprim.2011.07.012. Epub 2011 
      Oct 21.


PMID- 22018844
OWN - NLM
STAT- MEDLINE
DCOM- 20131212
LR  - 20120416
IS  - 1872-9177 (Electronic)
IS  - 1769-7255 (Linking)
VI  - 8
IP  - 2
DP  - 2012 Apr
TI  - [Bioethics and nephrology].
PG  - 113-5
LID - 10.1016/j.nephro.2011.08.001 [doi]
AB  - Bioethics concept is contemporary with the birth of nephrology. Fifty years ago, 
      renal biopsy, peritoneal dialysis, hemodialysis, renal transplantation created
      new situations, facing medical doctor with ethical choices, i.e. dilemmas between
      two or more unsatisfactory answers.
CI  - Copyright (c) 2011. Published by Elsevier SAS.
FAU - Huriet, Claude
AU  - Huriet C
AD  - 26, rue d'Ulm, 75005 Paris, France. claude.huriet@curie.net
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Ethique et nephrologie.
DEP - 20111021
PL  - France
TA  - Nephrol Ther
JT  - Nephrologie & therapeutique
JID - 101248950
SB  - IM
MH  - *Bioethics
MH  - Humans
MH  - Kidney Failure, Chronic/*therapy
MH  - Kidney Transplantation/*methods
MH  - Nephrology/*ethics
MH  - Renal Dialysis/*methods
EDAT- 2011/10/25 06:00
MHDA- 2013/12/18 06:00
CRDT- 2011/10/25 06:00
PHST- 2011/08/06 00:00 [received]
PHST- 2011/08/06 00:00 [revised]
PHST- 2011/08/06 00:00 [accepted]
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/10/25 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
AID - S1769-7255(11)00564-5 [pii]
AID - 10.1016/j.nephro.2011.08.001 [doi]
PST - ppublish
SO  - Nephrol Ther. 2012 Apr;8(2):113-5. doi: 10.1016/j.nephro.2011.08.001. Epub 2011
      Oct 21.


PMID- 22018758
OWN - NLM
STAT- MEDLINE
DCOM- 20121129
LR  - 20131121
IS  - 1097-6787 (Electronic)
IS  - 0190-9622 (Linking)
VI  - 67
IP  - 3
DP  - 2012 Sep
TI  - Review of treatment options for psoriasis in pregnant or lactating women: from
      the Medical Board of the National Psoriasis Foundation.
PG  - 459-77
LID - 10.1016/j.jaad.2011.07.039 [doi]
AB  - BACKGROUND: Treating psoriasis in pregnant and lactating women presents a special
      challenge. For ethical reasons, prospective randomized control trials have not
      been conducted in this patient population although these patients do encounter
      new-onset psoriasis in addition to flares and may require treatment throughout
      their pregnancies. OBJECTIVE: Our aim was to arrive at consensus recommendations 
      on treatment options for psoriasis in pregnant and lactating women. METHODS: The 
      literature was reviewed regarding all psoriasis therapies in pregnant and
      lactating women. RESULTS: Topical therapies including emollients and low- to
      moderate-potency topical steroids are first-line therapy for patients with
      limited psoriasis who are pregnant or breast-feeding. The consensus was that
      second-line treatment for pregnant women is narrowband ultraviolet B phototherapy
      or broadband ultraviolet B, if narrowband ultraviolet B is not available. Lastly,
      tumor necrosis factor-alpha inhibitors including adalimumab, etanercept, and
      infliximab may be used with caution as may cyclosporine and systemic steroids (in
      second and third trimesters). Some specific strategies may be used to minimize
      risk and exposure. LIMITATIONS: There are few evidence-based studies on treating 
      psoriasis in pregnant and lactating women. CONCLUSIONS: Because there will always
      be a question of ethical concerns placing pregnant and lactating women in
      prospective clinical trials, investigation of both conventional and biologic
      agents are unlikely to ever be performed. Some of these medications used to treat
      psoriasis are known abortifacients, mutagens, or teratogens and must be clearly
      avoided but others can be used with relative confidence in select patients with
      appropriate counseling of risks and benefits.
CI  - Copyright (c) 2011 American Academy of Dermatology, Inc. Published by Mosby, Inc.
      All rights reserved.
FAU - Bae, Yoon-Soo Cindy
AU  - Bae YS
AD  - Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts,
      USA.
FAU - Van Voorhees, Abby S
AU  - Van Voorhees AS
FAU - Hsu, Sylvia
AU  - Hsu S
FAU - Korman, Neil J
AU  - Korman NJ
FAU - Lebwohl, Mark G
AU  - Lebwohl MG
FAU - Young, Melody
AU  - Young M
FAU - Bebo, Bruce Jr
AU  - Bebo B Jr
FAU - Kimball, Alexa Boer
AU  - Kimball AB
CN  - National Psoriasis Foundation
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111022
PL  - United States
TA  - J Am Acad Dermatol
JT  - Journal of the American Academy of Dermatology
JID - 7907132
RN  - 0 (Glucocorticoids)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - WM0HAQ4WNM (Tacrolimus)
SB  - IM
MH  - Administration, Topical
MH  - Female
MH  - Glucocorticoids/administration & dosage
MH  - Humans
MH  - Immunosuppressive Agents/therapeutic use
MH  - Pregnancy
MH  - Pregnancy Complications/*therapy
MH  - Psoriasis/drug therapy/*therapy
MH  - Tacrolimus/therapeutic use
MH  - Tumor Necrosis Factor-alpha/antagonists & inhibitors
MH  - Ultraviolet Therapy
EDAT- 2011/10/25 06:00
MHDA- 2012/12/10 06:00
CRDT- 2011/10/25 06:00
PHST- 2010/11/24 00:00 [received]
PHST- 2011/07/27 00:00 [revised]
PHST- 2011/07/29 00:00 [accepted]
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/10/25 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - S0190-9622(11)00861-9 [pii]
AID - 10.1016/j.jaad.2011.07.039 [doi]
PST - ppublish
SO  - J Am Acad Dermatol. 2012 Sep;67(3):459-77. doi: 10.1016/j.jaad.2011.07.039. Epub 
      2011 Oct 22.


PMID- 22018733
OWN - NLM
STAT- MEDLINE
DCOM- 20120919
LR  - 20181201
IS  - 1873-5134 (Electronic)
IS  - 0738-3991 (Linking)
VI  - 87
IP  - 3
DP  - 2012 Jun
TI  - Participation in medical research; a systematic review of the understanding and
      experience of children and adolescents.
PG  - 268-76
LID - 10.1016/j.pec.2011.09.006 [doi]
AB  - OBJECTIVE: To systematically review the state of knowledge regarding the
      understanding and experience of psychological burden and risk of children and
      adolescents who participate in medical research. Further to provide
      recommendations to maximize understanding and minimize the burden and risk.
      METHODS: Studies were selected that focus on children and adolescents as source
      of information via PubMed and PsycINFO; search terms were medical research or
      trial or experiment, child or adolescent, non-therapeutic, therapeutic,
      psychology, consent or understanding, risk, burden or stress. RESULTS: Of 413
      abstracts identified, ten studies on understanding and eight on the experience of
      burden and risk met our selection criteria. Overall, understanding of the study
      purpose was reasonable, but low for the procedure. Understanding increased with
      age and appeared to be overestimated by the young participants. Research on
      experience of burden was scarce, but identified invasive procedures and
      procedures related to sexual development as the most burdensome. Only one study
      assessed psychological risks. CONCLUSION: Systematic evidence should be collected
      on the various aspects of medical procedures related to the experienced burden
      and risk. This will be useful in informing children and adolescents, parents and 
      medical ethical committees.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Hunfeld, Joke Aurelia Maria
AU  - Hunfeld JA
AD  - Department of Medical Psychology and Psychotherapy, Erasmus MC Rotterdam, The
      Netherlands. j.hunfeld@erasmusmc.nl
FAU - Passchier, Jan
AU  - Passchier J
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20111022
PL  - Ireland
TA  - Patient Educ Couns
JT  - Patient education and counseling
JID - 8406280
MH  - Adolescent
MH  - Biomedical Research
MH  - Child
MH  - *Clinical Trials as Topic
MH  - *Comprehension
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - Human Experimentation
MH  - Humans
MH  - Infant
MH  - Male
MH  - *Patient Selection
MH  - Psychology, Adolescent
MH  - Psychology, Child
MH  - Risk
EDAT- 2011/10/25 06:00
MHDA- 2012/09/20 06:00
CRDT- 2011/10/25 06:00
PHST- 2011/04/03 00:00 [received]
PHST- 2011/09/16 00:00 [revised]
PHST- 2011/09/18 00:00 [accepted]
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/10/25 06:00 [pubmed]
PHST- 2012/09/20 06:00 [medline]
AID - S0738-3991(11)00514-3 [pii]
AID - 10.1016/j.pec.2011.09.006 [doi]
PST - ppublish
SO  - Patient Educ Couns. 2012 Jun;87(3):268-76. doi: 10.1016/j.pec.2011.09.006. Epub
      2011 Oct 22.


PMID- 22017817
OWN - NLM
STAT- MEDLINE
DCOM- 20120117
LR  - 20211020
IS  - 1479-5876 (Electronic)
IS  - 1479-5876 (Linking)
VI  - 9
DP  - 2011 Oct 21
TI  - Stem cell therapy for idiopathic pulmonary fibrosis: a protocol proposal.
PG  - 182
LID - 10.1186/1479-5876-9-182 [doi]
AB  - BACKGROUND: Idiopathic pulmonary fibrosis represents a lethal form of progressive
      fibrotic lung disorder with gradually increasing incidence worldwide. Despite
      intense research efforts its pathogenesis is still elusive and controversial
      reflecting in the current disappointing status regarding its treatment. PATIENTS 
      AND METHODS: We report the first protocol proposal of a prospective, unicentric, 
      non-randomized, phase Ib clinical trial to study the safety and tolerability of
      the adipose-derived stem cells (ADSCs) stromal vascular fraction (SVF) as a
      therapeutic agent in IPF. After careful patient selection based on functional
      criteria (forced vital capacity-FVC > 50%, diffuse lung capacity for carbon
      monoxide-DLCO > 35% of the predicted values) all eligible subjects will be
      subjected to lipoaspiration resulting in the isolation of approximately 100- 500 
      gr of adipose tissue. After preparation, isolation and labelling ADSCs-SVF will
      be endobronchially infused to both lower lobes of the fibrotic lungs. Procedure
      will be repeated thrice at monthly intervals. Primary end-point represent safety 
      and tolerability data, while exploratory secondary end-points include assessment 
      of clinical functional and radiological status. RESULTS: Preliminary results
      recently presented in the form of an abstract seem promising and tantalizing
      since there were no cases of clinically significant allergic reactions,
      infections, disease acute exacerbations or ectopic tissue formation. In addition 
      6 months follow-up data revealed a marginal improvement at 6-minute walking
      distance and forced vital capacity. CONCLUSIONS: Adipose tissue represents an
      abundant, safe, ethically uncontested and potentially beneficial source of stem
      cells for patients with IPF. Larger multicenter phase II and III
      placebo-controlled clinical trials are sorely needed in order to prove efficacy. 
      However, pilot safety studies are of major importance and represent the first
      hamper that should be overcome to establish a rigid basis for larger clinical
      trials.
FAU - Tzouvelekis, Argyris
AU  - Tzouvelekis A
AD  - Department of Pneumonology, Medical School, Democritus University of Thrace,
      Alexandroupolis, Greece.
FAU - Koliakos, George
AU  - Koliakos G
FAU - Ntolios, Paschalis
AU  - Ntolios P
FAU - Baira, Irene
AU  - Baira I
FAU - Bouros, Evangelos
AU  - Bouros E
FAU - Oikonomou, Anastasia
AU  - Oikonomou A
FAU - Zissimopoulos, Athanassios
AU  - Zissimopoulos A
FAU - Kolios, George
AU  - Kolios G
FAU - Kakagia, Despoina
AU  - Kakagia D
FAU - Paspaliaris, Vassilis
AU  - Paspaliaris V
FAU - Kotsianidis, Ioannis
AU  - Kotsianidis I
FAU - Froudarakis, Marios
AU  - Froudarakis M
FAU - Bouros, Demosthenes
AU  - Bouros D
LA  - eng
PT  - Journal Article
DEP - 20111021
PL  - England
TA  - J Transl Med
JT  - Journal of translational medicine
JID - 101190741
RN  - 0 (Organotechnetium Compounds)
SB  - IM
MH  - Adipose Tissue/cytology
MH  - *Clinical Protocols
MH  - Clinical Trials, Phase I as Topic/*methods
MH  - Endpoint Determination
MH  - Humans
MH  - Idiopathic Pulmonary Fibrosis/diagnostic imaging/pathology/*therapy
MH  - Organotechnetium Compounds
MH  - Patient Discharge
MH  - Radionuclide Imaging
MH  - *Stem Cell Transplantation/adverse effects
MH  - Time Factors
PMC - PMC3213183
EDAT- 2011/10/25 06:00
MHDA- 2012/01/18 06:00
CRDT- 2011/10/25 06:00
PHST- 2011/08/15 00:00 [received]
PHST- 2011/10/21 00:00 [accepted]
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/10/25 06:00 [pubmed]
PHST- 2012/01/18 06:00 [medline]
AID - 1479-5876-9-182 [pii]
AID - 10.1186/1479-5876-9-182 [doi]
PST - epublish
SO  - J Transl Med. 2011 Oct 21;9:182. doi: 10.1186/1479-5876-9-182.


PMID- 22017505
OWN - NLM
STAT- MEDLINE
DCOM- 20120426
LR  - 20111215
IS  - 1753-8165 (Electronic)
IS  - 1753-8157 (Linking)
VI  - 37
IP  - 1
DP  - 2012 Jan
TI  - Information technology and hospice palliative care: social, cultural, ethical and
      technical implications in a rural setting.
PG  - 37-50
LID - 10.3109/17538157.2011.613553 [doi]
AB  - OBJECTIVE: There is a need to better understand the specific settings in which
      health information technology (HIT) is used and implemented. Factors that will
      determine the successful implementation of HIT are context-specific and often
      reside not at the technical level but rather at the process and people level.
      This paper provides the results of a needs assessment for HIT to support hospice 
      palliative care (HPC) delivery in rural settings. METHODS: Roundtable discussions
      using the nominal group technique were done to identify priority issues regarding
      HIT usage to support rural HPC delivery. Qualitative content analysis was then
      used to identify sociotechnical themes from the roundtable data. RESULTS: Twenty 
      priority issues were identified at the roundtable session. Content analysis
      grouped the priority issues into one central theme and five supporting themes to 
      form a sociotechnical framework for patient-centered care in rural settings.
      CONCLUSION: There are several sociotechnical themes and associated issues that
      need to be considered prior to implementing HIT in rural HPC settings. Proactive 
      evaluation of these issues can enhance HIT implementation and also help to make
      ethical aspects of HIT design more explicit.
FAU - Kuziemsky, Craig
AU  - Kuziemsky C
AD  - Telfer School of Management, University of Ottawa, Ottawa, ON, Canada.
      kuziemsky@telfer.uottawa.ca
FAU - Jewers, Heather
AU  - Jewers H
FAU - Appleby, Brenda
AU  - Appleby B
FAU - Foshay, Neil
AU  - Foshay N
FAU - Maccaull, Wendy
AU  - Maccaull W
FAU - Miller, Keith
AU  - Miller K
FAU - Macdonald, Madonna
AU  - Macdonald M
LA  - eng
PT  - Journal Article
DEP - 20111021
PL  - England
TA  - Inform Health Soc Care
JT  - Informatics for health & social care
JID - 101475011
SB  - IM
MH  - *Attitude of Health Personnel
MH  - *Culture
MH  - Health Personnel
MH  - Health Policy
MH  - Hospice Care/ethics/*organization & administration
MH  - Humans
MH  - Information Services
MH  - Interprofessional Relations
MH  - Medical Informatics/ethics/*organization & administration
MH  - Palliative Care/ethics/*organization & administration
MH  - Patient-Centered Care/ethics/organization & administration
MH  - Politics
MH  - Qualitative Research
MH  - Quality of Health Care/ethics/organization & administration
MH  - Rural Health Services/ethics/*organization & administration
MH  - Software Design
MH  - User-Computer Interface
EDAT- 2011/10/25 06:00
MHDA- 2012/04/27 06:00
CRDT- 2011/10/25 06:00
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/10/25 06:00 [pubmed]
PHST- 2012/04/27 06:00 [medline]
AID - 10.3109/17538157.2011.613553 [doi]
PST - ppublish
SO  - Inform Health Soc Care. 2012 Jan;37(1):37-50. doi: 10.3109/17538157.2011.613553. 
      Epub 2011 Oct 21.


PMID- 22016935
OWN - NLM
STAT- MEDLINE
DCOM- 20111209
LR  - 20111024
IS  - 1660-9379 (Print)
IS  - 1660-9379 (Linking)
VI  - 7
IP  - 309
DP  - 2011 Sep 21
TI  - [Ethical issues in psychiatry under coercion].
PG  - 1806, 1808-11
AB  - Psychiatry is now subject to two apparently contradictory movements. On the one
      hand, the need to respect the autonomy and rights of patients is reinforced and
      coercive measures are strictly defined and limited. On the other hand, security
      concerns in our society leads to prosecution of psychiatric disorders, especially
      when accompanied by behavioral problems or criminal acts. In these situations of 
      compulsory treatment or care provided in prisons, a number of dilemmas emerge.
      The place of the healthcare professional in treatments ordered by the Judge and
      problems related to administrative detention are discussed in more detail.
FAU - Gravier, Bruno
AU  - Gravier B
AD  - Service de Medecine et Psychiatrie Penitentarie, Departement de Psychiatrie,
      CHUV, 1011 Lausanne. Bruno.Gravier@chuv.ch
FAU - Eytan, Ariel
AU  - Eytan A
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Enjeux ethiques de la psychiatrie sous contrainte.
PL  - Switzerland
TA  - Rev Med Suisse
JT  - Revue medicale suisse
JID - 101219148
RN  - 0 (Hypnotics and Sedatives)
SB  - IM
MH  - Caregivers/ethics
MH  - *Coercion
MH  - Humans
MH  - Hypnotics and Sedatives/therapeutic use
MH  - Mental Disorders/*therapy
MH  - Patient Rights/ethics
MH  - Personal Autonomy
MH  - Physician-Patient Relations/ethics
MH  - *Prisons
MH  - Psychiatry/*ethics
MH  - Restraint, Physical/ethics
MH  - Security Measures/*ethics
MH  - *Violence
EDAT- 2011/10/25 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/10/25 06:00
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/10/25 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
PST - ppublish
SO  - Rev Med Suisse. 2011 Sep 21;7(309):1806, 1808-11.


PMID- 22016900
OWN - NLM
STAT- MEDLINE
DCOM- 20111102
LR  - 20110923
IS  - 1026-9428 (Print)
IS  - 1026-9428 (Linking)
IP  - 7
DP  - 2011
TI  - [Bioethical aspects of epidemiologic research concerning occupational risk].
PG  - 1-4
AB  - The author analysed peculiarities of ethic examination for occupational risk
      research in industrial medicine. Findings are that occupational risk research
      involving humans as examinees have significant social and individual value,
      therefore ethically justified. The article covers the most important points of
      the study design, possible sources of preference conflicts in industrial
      medicine. The study results are important for ethic committees, when considering 
      the studies connected with examination of occupational populations.
FAU - Trubetskov, A D
AU  - Trubetskov AD
LA  - rus
PT  - English Abstract
PT  - Journal Article
PL  - Russia (Federation)
TA  - Med Tr Prom Ekol
JT  - Meditsina truda i promyshlennaia ekologiia
JID - 9434213
SB  - IM
MH  - *Bioethical Issues
MH  - *Epidemiologic Research Design
MH  - Humans
MH  - Occupational Diseases/*epidemiology/etiology
MH  - *Occupational Health
MH  - Occupational Medicine/*ethics
MH  - Risk
EDAT- 2011/10/25 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/10/25 06:00
PHST- 2011/10/25 06:00 [entrez]
PHST- 2011/10/25 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
PST - ppublish
SO  - Med Tr Prom Ekol. 2011;(7):1-4.


PMID- 22015907
OWN - NLM
STAT- MEDLINE
DCOM- 20111212
LR  - 20210107
IS  - 1873-233X (Electronic)
IS  - 0029-7844 (Linking)
VI  - 118
IP  - 5
DP  - 2011 Nov
TI  - ACOG Committee Opinion No. 510: Ethical ways for physicians to market a practice.
PG  - 1195-1197
LID - 10.1097/AOG.0b013e31823b17d0 [doi]
AB  - It is ethical for physicians to market their practices provided that the
      communication is truthful and not misleading, deceptive, or discriminatory. All
      paid advertising must be clearly identified as such. Producing fair and accurate 
      advertising of medical practices and services can be challenging. It often is
      difficult to include detailed information because of cost and size restrictions
      or the limitations of the media form that has been selected. If the specific
      advertising form does not lend itself to clear and accurate description, an
      alternative media format should be selected. Advertising that seeks to denigrate 
      the competence of other individual professionals or group practices is always
      unethical.
LA  - eng
PT  - Guideline
PT  - Journal Article
PL  - United States
TA  - Obstet Gynecol
JT  - Obstetrics and gynecology
JID - 0401101
SB  - IM
MH  - Advertising/*ethics
MH  - Gynecology/ethics
MH  - Obstetrics/ethics
MH  - Practice Management, Medical/*ethics
MH  - Prejudice
MH  - Vulnerable Populations
EDAT- 2011/10/22 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/10/22 06:00
PHST- 2011/10/22 06:00 [entrez]
PHST- 2011/10/22 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 10.1097/AOG.0b013e31823b17d0 [doi]
AID - 00006250-201111000-00049 [pii]
PST - ppublish
SO  - Obstet Gynecol. 2011 Nov;118(5):1195-1197. doi: 10.1097/AOG.0b013e31823b17d0.


PMID- 22015887
OWN - NLM
STAT- MEDLINE
DCOM- 20111212
LR  - 20210107
IS  - 1873-233X (Electronic)
IS  - 0029-7844 (Linking)
VI  - 118
IP  - 5
DP  - 2011 Nov
TI  - Three is a crowd: the new doctor-patient-policymaker relationship.
PG  - 1164-1168
LID - 10.1097/AOG.0b013e31823188d6 [doi]
AB  - A recent increase in legislative initiatives involving specific aspects of the
      practice of medicine is challenging traditional doctor-patient relationships. A
      Florida state law prohibiting physicians from asking patients about the presence 
      of guns in the home could potentially result in real harm because of the risk of 
      childhood injuries, domestic violence, suicide, and homicide. A number of states 
      have specific language physicians are supposed to use when obtaining consent for 
      pregnancy terminations. Some of these items required by law to be contained in
      the informed consent are not based on science, but instead on political beliefs. 
      Other legislative initiatives involve issues as varied as hysterectomy consents, 
      glomerular filtration rates, family planning, and palliative care. Laws that
      prohibit physicians from asking patients certain questions may be violating
      doctors' First Amendment rights. Laws mandating what information is contained in 
      procedural consent forms and requiring certain scripts to be utilized may
      interfere with patients' ability to have accurate, unbiased, objective
      information to assist in their decision making. Physicians may be caught in the
      untenable position of balancing their professional and ethical obligations to
      their patients with their duty to obey the law as citizens. Physicians should be 
      involved in legislative advocacy to try to prevent policy makers from legislating
      the practice of medicine. The American Congress of Obstetricians and
      Gynecologists' Committee on Ethics should consider review of this evolving issue.
FAU - Tracy, Erin E
AU  - Tracy EE
AD  - From the Department of Obstetrics and Gynecology, Massachusetts General Hospital,
      Boston, Massachusetts.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Obstet Gynecol
JT  - Obstetrics and gynecology
JID - 0401101
SB  - IM
MH  - Abortion, Induced/legislation & jurisprudence
MH  - Firearms
MH  - Hysterectomy
MH  - Informed Consent
MH  - *Legislation, Medical
MH  - Palliative Care/legislation & jurisprudence
MH  - *Physician-Patient Relations
EDAT- 2011/10/22 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/10/22 06:00
PHST- 2011/10/22 06:00 [entrez]
PHST- 2011/10/22 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 10.1097/AOG.0b013e31823188d6 [doi]
AID - 00006250-201111000-00028 [pii]
PST - ppublish
SO  - Obstet Gynecol. 2011 Nov;118(5):1164-1168. doi: 10.1097/AOG.0b013e31823188d6.


PMID- 22015217
OWN - NLM
STAT- MEDLINE
DCOM- 20140106
LR  - 20121204
IS  - 1532-3099 (Electronic)
IS  - 0266-6138 (Linking)
VI  - 28
IP  - 6
DP  - 2012 Dec
TI  - Irish and New Zealand midwives' expertise in expectant management of the third
      stage of labour: the 'MEET' study.
PG  - 733-9
LID - 10.1016/j.midw.2011.08.008 [doi]
LID - S0266-6138(11)00124-0 [pii]
AB  - OBJECTIVE: to explore the views of expert midwives in Ireland and New Zealand of 
      the skills they employ in expectant management of the third stage of labour
      (EMTSL). DESIGN: university ethical approval was granted for a qualitative
      descriptive study in 2010. Recorded, semi-structured interviews were undertaken. 
      Constant comparative analysis was used. SETTING: community birth settings in
      Ireland and New Zealand. PARTICIPANTS: 27 consenting midwives who used EMTSL in
      at least 30% of births, with PPH rates less than 4%. FINDINGS: the majority of
      respondents believed the third stage was a special time of parent-baby discovery 
      and 'watchful waiting', with no intervention necessary. Great importance was
      placed on women's feelings, behaviour and a calm environment. Skin-to-skin
      contact, breast feeding, not clamping the cord, upright positions and maternal
      effort, sometimes assisted by gentle cord-traction were also used. KEY
      CONCLUSIONS: some components of EMTSL identified by these expert midwives are not
      recorded in text-books, but are based on experience and expertise. These elements
      of EMTSL add to midwifery knowledge and provide a basis for further discussion on
      how normal physiology can be supported during the third stage. IMPLICATIONS FOR
      PRACTICE: use of these elements is recommended for women who request EMTSL, and
      for those in countries without ready access to uterotonics.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Begley, Cecily M
AU  - Begley CM
AD  - School of Nursing and Midwifery, Trinity College Dublin, 24, D'Olier St, Dublin
      2, Ireland. cbegley@tcd.ie
FAU - Guilliland, Karen
AU  - Guilliland K
FAU - Dixon, Lesley
AU  - Dixon L
FAU - Reilly, Mary
AU  - Reilly M
FAU - Keegan, Caroline
AU  - Keegan C
LA  - eng
PT  - Journal Article
DEP - 20111019
PL  - Scotland
TA  - Midwifery
JT  - Midwifery
JID - 8510930
MH  - Adult
MH  - *Clinical Competence
MH  - Female
MH  - Humans
MH  - Ireland
MH  - *Labor Stage, Third
MH  - Midwifery/*methods
MH  - New Zealand
MH  - *Nurse's Role
MH  - *Nurse-Patient Relations
MH  - Nursing Methodology Research
MH  - Patient Safety
MH  - Postnatal Care/*methods
MH  - Postpartum Period/psychology
MH  - Pregnancy
MH  - Young Adult
EDAT- 2011/10/22 06:00
MHDA- 2014/01/07 06:00
CRDT- 2011/10/22 06:00
PHST- 2011/06/07 00:00 [received]
PHST- 2011/08/19 00:00 [revised]
PHST- 2011/08/25 00:00 [accepted]
PHST- 2011/10/22 06:00 [entrez]
PHST- 2011/10/22 06:00 [pubmed]
PHST- 2014/01/07 06:00 [medline]
AID - S0266-6138(11)00124-0 [pii]
AID - 10.1016/j.midw.2011.08.008 [doi]
PST - ppublish
SO  - Midwifery. 2012 Dec;28(6):733-9. doi: 10.1016/j.midw.2011.08.008. Epub 2011 Oct
      19.


PMID- 22015184
OWN - NLM
STAT- MEDLINE
DCOM- 20120315
LR  - 20191210
IS  - 1672-1977 (Print)
IS  - 1672-1977 (Linking)
VI  - 9
IP  - 10
DP  - 2011 Oct
TI  - Duplicate publication cases in the field of Kampo (Japanese herbal medicine) in
      Japan.
PG  - 1055-60
AB  - OBJECTIVE: Duplicate publication has a negative influence on science and
      publishing communities. We found duplicate publication cases in the field of
      Kampo (traditional Japanese herbal medicine) while compiling the Evidence Reports
      of Kampo Treatment (EKAT) 2009 published by the Special Committee for
      Evidence-based Medicine (EBM), the Japan Society for Oriental Medicine (JSOM).
      Therefore, we checked the articles that appeared in the EKAT 2009 and analyzed
      how duplicate publication occurred. METHODS: The EKAT 2009 contains structured
      abstracts of 320 randomized controlled trial studies. We checked 384 articles
      referred to by the structured abstracts to identify duplicate publications
      according to the following criteria: hypothesis and results are the same; the
      authors are in common; no description as to a secondary publication is offered;
      no cross-references to related papers. RESULTS: Eleven articles that appeared in 
      the EKAT 2009 were identified as duplicate publications. These articles showed
      four duplicate patterns: reproducing an already published article with the same
      sample data and results (n=3); adding new sample data with the same results
      (n=1); reporting part of the preliminary sample with the same results (n=1);
      translating an original article into another language (n=6). CONCLUSION: Among
      the 11 duplicate publications in the EKAT 2009, we discovered 4 duplicate
      patterns. These patterns reflect Japanese researchers' behavior that leads to the
      production of duplicate publications: the authors complete a previous article and
      submit it to a more prestigious journal; translate an original English article
      for Japanese physicians without referring to the original paper. To raise the
      awareness of duplicate publication among researchers, the understanding of
      publication ethics is essential.
FAU - Kitagawa, Masamichi
AU  - Kitagawa M
AD  - The Jikei University School of Medicine, Tokyo, Japan. kitagawa@jikei.ac.jp
FAU - Tsutani, Kiichiro
AU  - Tsutani K
LA  - eng
PT  - Journal Article
PL  - China
TA  - Zhong Xi Yi Jie He Xue Bao
JT  - Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
JID - 101199657
SB  - IM
MH  - Bibliometrics
MH  - *Duplicate Publications as Topic
MH  - Japan
MH  - *Medicine, Kampo
MH  - Periodicals as Topic
EDAT- 2011/10/22 06:00
MHDA- 2012/03/16 06:00
CRDT- 2011/10/22 06:00
PHST- 2011/10/22 06:00 [entrez]
PHST- 2011/10/22 06:00 [pubmed]
PHST- 2012/03/16 06:00 [medline]
AID - jcim20111003 [pii]
AID - 10.3736/jcim20111003 [doi]
PST - ppublish
SO  - Zhong Xi Yi Jie He Xue Bao. 2011 Oct;9(10):1055-60. doi: 10.3736/jcim20111003.


PMID- 22014992
OWN - NLM
STAT- MEDLINE
DCOM- 20120217
LR  - 20111021
IS  - 1879-1131 (Electronic)
IS  - 0738-081X (Linking)
VI  - 29
IP  - 6
DP  - 2011 Nov-Dec
TI  - In it but not of it: relationships of medicine with government and politics.
PG  - 704-7
LID - 10.1016/j.clindermatol.2011.08.031 [doi]
AB  - Medicine evolved in parallel with religion. Its practitioners developed their
      skills by selection, training, and culling. Codes of loyalties, behavior, and
      ethics emerged. This made them distinct. In common with government and politics, 
      medicine has to do with the common weal. Still, the relationship of patients with
      physicians is based on a different kind of agreement than that with government or
      politics. Although physicians must participate in specific functions of
      government and politics related to their tasks, they act as a body that has
      specific limitations and rights (fuero). This is the backbone of medicine as a
      profession. Current tendencies favor the strengthening of governments and
      economic realities tend to favor the submission of physicians to those that
      control means of payment. A further enhancement of these trends might mark the
      end of medicine as a liberal profession. Individual decision by physicians to
      maintain a proud and necessary heritage and the creation of an effective World
      Medical College are 2 strategies that might thwart the danger of medicine's
      demise.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Goihman-Yahr, Mauricio
AU  - Goihman-Yahr M
AD  - Department of Dermatology and Immunology, Vargas School of Medicine, Central
      University of Venezuela, 1050-Ciudad Universitaria, 1051 Caracas, Venezuela.
      mgoihmanyahr@yahoo.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Dermatol
JT  - Clinics in dermatology
JID - 8406412
SB  - IM
MH  - *Government
MH  - Humans
MH  - *Medicine
MH  - *Politics
EDAT- 2011/10/22 06:00
MHDA- 2012/02/18 06:00
CRDT- 2011/10/22 06:00
PHST- 2011/10/22 06:00 [entrez]
PHST- 2011/10/22 06:00 [pubmed]
PHST- 2012/02/18 06:00 [medline]
AID - S0738-081X(11)00235-5 [pii]
AID - 10.1016/j.clindermatol.2011.08.031 [doi]
PST - ppublish
SO  - Clin Dermatol. 2011 Nov-Dec;29(6):704-7. doi: 10.1016/j.clindermatol.2011.08.031.


PMID- 22014965
OWN - NLM
STAT- MEDLINE
DCOM- 20120208
LR  - 20111205
IS  - 1527-9995 (Electronic)
IS  - 0090-4295 (Linking)
VI  - 78
IP  - 6
DP  - 2011 Dec
TI  - Defining patient selection for prostate-sparing cystectomy in squamous cell
      carcinoma of the urinary bladder associated with bilharziasis: an overview of 236
      patients.
PG  - 1351-4
LID - 10.1016/j.urology.2011.06.054 [doi]
AB  - OBJECTIVE: To determine possible risk factors associated with prostate invasion
      in patients with squamous cell carcinoma (SCC) of the urinary bladder associated 
      with bilharziasis. METHODS: After obtaining approval from the medical ethics
      committee, we reviewed the clinical and pathologic data from 236 male patients in
      our department between January 2006 and October 2010 who were treated with
      radical cystoprostatectomy and proved to have SCC associated with bilharziasis.
      We reviewed the clinical and histopathologic data regarding prostate infiltration
      from SCC of the urinary bladder associated with bilharziasis. RESULTS:
      Two-hundred thirty-six patients were included in this study. Prostate
      infiltration was present in 14 patients (5.9%). Tumor located in the bladder neck
      (P = .000001), tumors >5 cm (P = .009), and advanced clinical tumor stage (P =
      .000001) were associated with highly statistically significant increased risk of 
      prostate invasion from SCC of the urinary bladder. Different patients' ages, high
      tumor grade, and regional lymph nodes' metastasis were not associated with
      increased risk of prostate invasion from SCC of the urinary bladder. CONCLUSION: 
      Prostate infiltration from SCC of the urinary bladder (which is associated with
      bilharziasis) is not uncommon. Tumor >5 cm, bladder neck tumor, and high clinical
      tumor stages should be considered at least relative contraindications for
      prostate-sparing cystectomy.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Abdelsalam, Yaser M
AU  - Abdelsalam YM
AD  - Department of Urology, Faculty of Medicine, Assiut University, Assiut, Egypt.
FAU - Mokhtar, Ahmad A
AU  - Mokhtar AA
FAU - Kurkar, Adel A
AU  - Kurkar AA
FAU - Saleh, Medhat A
AU  - Saleh MA
FAU - el-Ganainy, Ehab O
AU  - el-Ganainy EO
LA  - eng
PT  - Journal Article
DEP - 20111019
PL  - United States
TA  - Urology
JT  - Urology
JID - 0366151
SB  - IM
CIN - Urology. 2011 Dec;78(6):1354-5; author reply 1355. PMID: 22137702
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/complications/*pathology/*surgery
MH  - Cystectomy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Invasiveness
MH  - Organ Sparing Treatments
MH  - *Patient Selection
MH  - Prostatectomy
MH  - Prostatic Neoplasms/*pathology/*surgery
MH  - Retrospective Studies
MH  - Schistosomiasis/complications
MH  - Urinary Bladder Neoplasms/complications/*pathology/*surgery
MH  - Young Adult
EDAT- 2011/10/22 06:00
MHDA- 2012/02/09 06:00
CRDT- 2011/10/22 06:00
PHST- 2011/03/31 00:00 [received]
PHST- 2011/05/10 00:00 [revised]
PHST- 2011/06/04 00:00 [accepted]
PHST- 2011/10/22 06:00 [entrez]
PHST- 2011/10/22 06:00 [pubmed]
PHST- 2012/02/09 06:00 [medline]
AID - S0090-4295(11)02201-1 [pii]
AID - 10.1016/j.urology.2011.06.054 [doi]
PST - ppublish
SO  - Urology. 2011 Dec;78(6):1351-4. doi: 10.1016/j.urology.2011.06.054. Epub 2011 Oct
      19.


PMID- 22014954
OWN - NLM
STAT- MEDLINE
DCOM- 20120315
LR  - 20220310
IS  - 1879-355X (Electronic)
IS  - 0360-3016 (Linking)
VI  - 82
IP  - 3
DP  - 2012 Mar 1
TI  - Dynamic contrast-enhanced MRI of cervical cancers: temporal percentile screening 
      of contrast enhancement identifies parameters for prediction of
      chemoradioresistance.
PG  - e485-92
LID - 10.1016/j.ijrobp.2011.05.050 [doi]
AB  - PURPOSE: To systematically screen the tumor contrast enhancement of locally
      advanced cervical cancers to assess the prognostic value of two descriptive
      parameters derived from dynamic contrast-enhanced magnetic resonance imaging
      (DCE-MRI). METHODS AND MATERIALS: This study included a prospectively collected
      cohort of 81 patients who underwent DCE-MRI with gadopentetate dimeglumine before
      chemoradiotherapy. The following descriptive DCE-MRI parameters were extracted
      voxel by voxel and presented as histograms for each time point in the dynamic
      series: normalized relative signal increase (nRSI) and normalized area under the 
      curve (nAUC). The first to 100th percentiles of the histograms were included in a
      log-rank survival test, resulting in p value and relative risk maps of all
      percentile-time intervals for each DCE-MRI parameter. The maps were used to
      evaluate the robustness of the individual percentile-time pairs and to construct 
      prognostic parameters. Clinical endpoints were locoregional control and
      progression-free survival. The study was approved by the institutional ethics
      committee. RESULTS: The p value maps of nRSI and nAUC showed a large continuous
      region of percentile-time pairs that were significantly associated with
      locoregional control (p < 0.05). These parameters had prognostic impact
      independent of tumor stage, volume, and lymph node status on multivariate
      analysis. Only a small percentile-time interval of nRSI was associated with
      progression-free survival. CONCLUSIONS: The percentile-time screening identified 
      DCE-MRI parameters that predict long-term locoregional control after
      chemoradiotherapy of cervical cancer.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Andersen, Erlend K F
AU  - Andersen EK
AD  - Department of Medical Physics, Oslo University Hospital, Oslo, Norway.
FAU - Hole, Knut Hakon
AU  - Hole KH
FAU - Lund, Kjersti V
AU  - Lund KV
FAU - Sundfor, Kolbein
AU  - Sundfor K
FAU - Kristensen, Gunnar B
AU  - Kristensen GB
FAU - Lyng, Heidi
AU  - Lyng H
FAU - Malinen, Eirik
AU  - Malinen E
LA  - eng
PT  - Journal Article
DEP - 20111017
PL  - United States
TA  - Int J Radiat Oncol Biol Phys
JT  - International journal of radiation oncology, biology, physics
JID - 7603616
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adenocarcinoma/mortality/pathology/therapy
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Area Under Curve
MH  - Carcinoma, Adenosquamous/mortality/pathology/therapy
MH  - Carcinoma, Squamous Cell/mortality/pathology/therapy
MH  - *Chemoradiotherapy
MH  - Contrast Media
MH  - Disease-Free Survival
MH  - *Drug Resistance, Neoplasm
MH  - Female
MH  - Gadolinium DTPA
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Middle Aged
MH  - Prognosis
MH  - Prospective Studies
MH  - *Radiation Tolerance
MH  - Tumor Burden
MH  - Uterine Cervical Neoplasms/mortality/pathology/*therapy
EDAT- 2011/10/22 06:00
MHDA- 2012/03/16 06:00
CRDT- 2011/10/22 06:00
PHST- 2011/02/21 00:00 [received]
PHST- 2011/05/18 00:00 [revised]
PHST- 2011/05/20 00:00 [accepted]
PHST- 2011/10/22 06:00 [entrez]
PHST- 2011/10/22 06:00 [pubmed]
PHST- 2012/03/16 06:00 [medline]
AID - S0360-3016(11)02791-X [pii]
AID - 10.1016/j.ijrobp.2011.05.050 [doi]
PST - ppublish
SO  - Int J Radiat Oncol Biol Phys. 2012 Mar 1;82(3):e485-92. doi:
      10.1016/j.ijrobp.2011.05.050. Epub 2011 Oct 17.


PMID- 22014915
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1556-3715 (Electronic)
IS  - 1556-3707 (Linking)
VI  - 10
IP  - 3
DP  - 2011 Sep
TI  - The 4 basic ethical principles that apply to forensic activities are respect for 
      autonomy, beneficence, nonmaleficence, and justice.
PG  - 225-6
LID - 10.1016/j.jcm.2011.08.004 [doi]
FAU - Jahn, Warren T
AU  - Jahn WT
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Chiropr Med
JT  - Journal of chiropractic medicine
JID - 101163637
PMC - PMC4863255
EDAT- 2011/10/22 06:00
MHDA- 2011/10/22 06:01
CRDT- 2011/10/22 06:00
PHST- 2011/10/22 06:00 [entrez]
PHST- 2011/10/22 06:00 [pubmed]
PHST- 2011/10/22 06:01 [medline]
AID - S1556-3707(11)00105-2 [pii]
AID - 10.1016/j.jcm.2011.08.004 [doi]
PST - ppublish
SO  - J Chiropr Med. 2011 Sep;10(3):225-6. doi: 10.1016/j.jcm.2011.08.004.


PMID- 22014887
OWN - NLM
STAT- MEDLINE
DCOM- 20120309
LR  - 20120123
IS  - 1878-5921 (Electronic)
IS  - 0895-4356 (Linking)
VI  - 65
IP  - 3
DP  - 2012 Mar
TI  - Normative arguments and new solutions for the unbiased registration and
      publication of clinical trials.
PG  - 276-81
LID - 10.1016/j.jclinepi.2011.07.002 [doi]
AB  - OBJECTIVE: To present a structured account of ethical problems and possible
      solutions related to selective publication and incomplete trial registration.
      STUDY DESIGN AND SETTING: The presentation of ethical problems and possible
      solutions is structured using the tools of conceptual normative analysis.
      RESULTS: Selective publication runs contrary to (1) principles of ethical
      research, such as social value and respect for participants, (2) sound medical
      decision making and clinical guideline development, (3) appropriate patient
      information, (4) public trust in clinical research, and (5) just allocation of
      public resources for clinical research. Reasons against the obligation of
      complete registration and publication of trials can be divided into (1)
      protection of private data and (2) commercial interests. Empirical findings
      indicate that selective publication and incomplete trial registration (1) are
      frequent, (2) extensively distort patient-relevant outcomes, and (3) affect a
      large number of patients. CONCLUSION: Empirical data and normative arguments
      outweigh their counterarguments and present a clear case in favor of an even more
      restrictive obligation to register trials. Institutional review boards and
      better-educated stakeholders might play a crucial role in facilitating unbiased
      registration and publication of clinical research. For evaluation purposes, the
      field needs better standards for study protocols.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Strech, Daniel
AU  - Strech D
AD  - CELLS-Centre for Ethics and Law in the Life Science, Institute for History,
      Ethics and Philosophy of Medicine, Hannover Medical School, Carl-Neuberg Strasse 
      Street 1, Hannover, Germany. strech.daniel@mh-hannover.de
LA  - eng
PT  - Journal Article
DEP - 20111019
PL  - United States
TA  - J Clin Epidemiol
JT  - Journal of clinical epidemiology
JID - 8801383
SB  - IM
MH  - Clinical Trials as Topic/*standards
MH  - *Empirical Research
MH  - Ethics Committees, Research
MH  - *Ethics, Research
MH  - Humans
MH  - *Publication Bias
MH  - Publishing/*ethics/standards
MH  - Registries/*standards
EDAT- 2011/10/22 06:00
MHDA- 2012/03/10 06:00
CRDT- 2011/10/22 06:00
PHST- 2010/09/10 00:00 [received]
PHST- 2011/06/06 00:00 [revised]
PHST- 2011/07/11 00:00 [accepted]
PHST- 2011/10/22 06:00 [entrez]
PHST- 2011/10/22 06:00 [pubmed]
PHST- 2012/03/10 06:00 [medline]
AID - S0895-4356(11)00220-4 [pii]
AID - 10.1016/j.jclinepi.2011.07.002 [doi]
PST - ppublish
SO  - J Clin Epidemiol. 2012 Mar;65(3):276-81. doi: 10.1016/j.jclinepi.2011.07.002.
      Epub 2011 Oct 19.


PMID- 22014862
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1556-3715 (Electronic)
IS  - 1556-3707 (Linking)
VI  - 10
IP  - 2
DP  - 2011 Jun
TI  - A randomized controlled trial of chiropractic management of the lower limb
      kinetic chain for the treatment of hip osteoarthritis: a study protocol.
PG  - 86-92
LID - 10.1016/j.jcm.2010.12.002 [doi]
AB  - OBJECTIVE: Our objective is to document the methodology of a randomized
      controlled clinical trial that demonstrates sound research methodology. The
      chiropractic treatment performed may be useful to allow practitioners to adopt a 
      similar approach when treating hip osteoarthritis. METHODS: This study is a
      registered, ethics-approved, single-blinded, randomized controlled clinical
      trial. Recruitment included a controlled media release, phone screening, and
      physical assessment to rule out nonosteoarthritic hip pain. Primary outcome
      measures were the McMaster Overall Therapy Effectiveness Tool and the Western
      Ontario and McMaster Universities Osteoarthritis Index, which were assessed at
      baseline and after 1, 3, 6, and 9 months. Participants were randomly allocated to
      1 of 2 intervention groups: protocol A or B. Protocol A received preadjustive
      stretches of hip musculature, followed by hip manipulation. Protocol B received
      the above intervention, followed by an additional assessment and chiropractic
      treatment of the lower limb kinetic chain. Participants received 9 treatments and
      then after 3 months were offered an additional 6 treatments. Statistics will be
      performed by an independent biostatistician. RESULTS: This article provides a
      valid and reliable protocol for a randomized controlled trial for the treatment
      of hip osteoarthritis with chiropractic care. Data should be analyzed for
      statistical significance to provide evidence for the efficacy of the
      interventions. CONCLUSIONS: This study is an example of sound research
      methodology, which was scored as excellent on the Physiotherapy Evidence Database
      scale. Findings may be important in the scope of treatment, providing evidence
      for conservative management options for hip osteoarthritis.
CI  - Copyright (c) 2011 National University of Health Sciences. Published by Elsevier 
      Inc. All rights reserved.
FAU - de Luca, Katie
AU  - de Luca K
AD  - Private Practice, Australia; Adjunct Research Faculty, Department of Research,
      Cleveland Chiropractic College, Los Angeles, CA 90004.
FAU - Pollard, Henry
AU  - Pollard H
FAU - Brantingham, James
AU  - Brantingham J
FAU - Globe, Gary
AU  - Globe G
FAU - Cassa, Tammy
AU  - Cassa T
LA  - eng
PT  - Journal Article
DEP - 20110405
PL  - United States
TA  - J Chiropr Med
JT  - Journal of chiropractic medicine
JID - 101163637
PMC - PMC3110413
EDAT- 2011/10/22 06:00
MHDA- 2011/10/22 06:01
CRDT- 2011/10/22 06:00
PHST- 2010/02/15 00:00 [received]
PHST- 2010/12/15 00:00 [revised]
PHST- 2010/12/28 00:00 [accepted]
PHST- 2011/10/22 06:00 [entrez]
PHST- 2011/10/22 06:00 [pubmed]
PHST- 2011/10/22 06:01 [medline]
AID - S1556-3707(11)00035-6 [pii]
AID - 10.1016/j.jcm.2010.12.002 [doi]
PST - ppublish
SO  - J Chiropr Med. 2011 Jun;10(2):86-92. doi: 10.1016/j.jcm.2010.12.002. Epub 2011
      Apr 5.


PMID- 22014555
OWN - NLM
STAT- MEDLINE
DCOM- 20120320
LR  - 20161125
IS  - 1365-229X (Electronic)
IS  - 0009-9260 (Linking)
VI  - 67
IP  - 3
DP  - 2012 Mar
TI  - Magnetic resonance elastography: feasibility of liver stiffness measurements in
      healthy volunteers at 3T.
PG  - 258-62
LID - 10.1016/j.crad.2011.08.022 [doi]
AB  - AIM: To demonstrate the feasibility of obtaining liver stiffness measurements
      with magnetic resonance elastography (MRE) at 3T in normal healthy volunteers
      using the same technique that has been successfully applied at 1.5 T. METHODS AND
      MATERIALS: The study was approved by the local ethics committee and written
      informed consent was obtained from all volunteers. Eleven volunteers (mean age 35
      +/- 9 years) with no history of gastrointestinal, hepatobiliary, or
      cardiovascular disease were recruited. The magnetic resonance imaging (MRI)
      protocol included a gradient echo-based MRE sequence using a 60 Hz pneumatic
      excitation. The MRE images were processed using a local frequency estimation
      inversion algorithm to provide quantitative stiffness maps. Adequate image
      quality was assessed subjectively by demonstrating the presence of visible
      propagating waves within the liver parenchyma underlying the driver location.
      Liver stiffness values were obtained using manually placed regions of interest
      (ROI) outlining the liver margins on the gradient echo wave images, which were
      then mapped onto the corresponding stiffness image. The mean stiffness values
      from two adjacent sections were recorded. RESULTS: Eleven volunteers underwent
      MRE. The quality of the MRE images was adequate in all the volunteers. The mean
      liver stiffness for the group was 2.3 +/- 0.38 kPa (ranging from 1.7-2.8 kPa).
      CONCLUSIONS: This preliminary work using MRE at 3T in healthy volunteers
      demonstrates the feasibility of liver stiffness evaluation at 3T without
      modification of the approach used at 1.5 T. Adequate image quality and normal MRE
      values were obtained in all volunteers. The obtained stiffness values were in the
      range of those reported for healthy volunteers in previous studies at 1.5 T.
      There was good interobserver reproducibility in the stiffness measurements.
CI  - Copyright (c) 2011 The Royal College of Radiologists. Published by Elsevier Ltd. 
      All rights reserved.
FAU - Mannelli, L
AU  - Mannelli L
AD  - Department of Radiology, Addenbrooke's Hospital and University of Cambridge,
      Cambridge, UK. mannellilorenzo@yahoo.it
FAU - Godfrey, E
AU  - Godfrey E
FAU - Graves, M J
AU  - Graves MJ
FAU - Patterson, A J
AU  - Patterson AJ
FAU - Beddy, P
AU  - Beddy P
FAU - Bowden, D
AU  - Bowden D
FAU - Joubert, I
AU  - Joubert I
FAU - Priest, A N
AU  - Priest AN
FAU - Lomas, D J
AU  - Lomas DJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111019
PL  - England
TA  - Clin Radiol
JT  - Clinical radiology
JID - 1306016
SB  - IM
MH  - Adult
MH  - Algorithms
MH  - Elasticity Imaging Techniques/*methods
MH  - Female
MH  - Humans
MH  - Image Enhancement/methods
MH  - Image Interpretation, Computer-Assisted
MH  - Liver/*anatomy & histology/diagnostic imaging
MH  - Male
MH  - Middle Aged
MH  - Reproducibility of Results
EDAT- 2011/10/22 06:00
MHDA- 2012/03/21 06:00
CRDT- 2011/10/22 06:00
PHST- 2011/06/29 00:00 [received]
PHST- 2011/08/18 00:00 [revised]
PHST- 2011/08/22 00:00 [accepted]
PHST- 2011/10/22 06:00 [entrez]
PHST- 2011/10/22 06:00 [pubmed]
PHST- 2012/03/21 06:00 [medline]
AID - S0009-9260(11)00402-8 [pii]
AID - 10.1016/j.crad.2011.08.022 [doi]
PST - ppublish
SO  - Clin Radiol. 2012 Mar;67(3):258-62. doi: 10.1016/j.crad.2011.08.022. Epub 2011
      Oct 19.


PMID- 22014284
OWN - NLM
STAT- MEDLINE
DCOM- 20120523
LR  - 20161020
IS  - 1741-203X (Electronic)
IS  - 1041-6102 (Linking)
VI  - 24
IP  - 3
DP  - 2012 Mar
TI  - Ethical aspects of using GPS for tracking people with dementia: recommendations
      for practice.
PG  - 358-66
LID - 10.1017/S1041610211001888 [doi]
AB  - BACKGROUND: Problems with out-of-home mobility are among the more common
      behavioral disturbances in dementia. Today people with dementia can be aided by
      easily accessible assistive technologies, such as tracking devices using Global
      Positioning Systems (GPS). Attitudes toward these technologies are still
      inconclusive and their use with people with dementia raises ethical concerns. The
      lack of ethical consensus on the use of GPS for people with dementia underlines
      the need for clearer policies and practical guidelines. METHODS: Here we
      summarize qualitative and quantitative findings from a larger research project on
      the ethical aspects of using GPS for tracking people with dementia. RESULTS: The 
      findings are formulated in a list of recommendations for policy-makers as well as
      for professional and family caregivers. Among other points, the recommendations
      indicate that the preferences and best interests of the people with dementia
      should be central to the difficult decisions required in dementia care. Further, 
      no-one should be coerced into using tracking technology and, where possible,
      people with dementia must be involved in the decision-making and their consent
      sought. CONCLUSIONS: The decision whether, when and how to use GPS for tracking
      people with dementia should be made at the time of diagnosis jointly by the
      person with dementia, his/her family and professional caregivers. This decision
      should be made in formal structured meetings facilitated by a professional team.
FAU - Landau, Ruth
AU  - Landau R
AD  - Paul Baerwald School of Social Work and Social Welfare, The Hebrew University of 
      Jerusalem, Jerusalem, Israel. mslanda@mscc.huji.ac.il
FAU - Werner, Shirli
AU  - Werner S
LA  - eng
PT  - Guideline
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20111003
PL  - England
TA  - Int Psychogeriatr
JT  - International psychogeriatrics
JID - 9007918
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alzheimer Disease/diagnosis/*nursing/psychology
MH  - Attitude
MH  - Cooperative Behavior
MH  - Equipment Design
MH  - *Ethics, Medical
MH  - Female
MH  - Focus Groups
MH  - Geographic Information Systems/*ethics/instrumentation
MH  - Health Policy
MH  - Home Nursing/ethics
MH  - Humans
MH  - Interdisciplinary Communication
MH  - Male
MH  - Middle Aged
MH  - Patient Acceptance of Health Care
MH  - Patient Care Team
MH  - Patient Participation
MH  - Personal Autonomy
MH  - Privacy
MH  - Surveys and Questionnaires
MH  - Wandering Behavior
EDAT- 2011/10/22 06:00
MHDA- 2012/05/24 06:00
CRDT- 2011/10/22 06:00
PHST- 2011/10/22 06:00 [entrez]
PHST- 2011/10/22 06:00 [pubmed]
PHST- 2012/05/24 06:00 [medline]
AID - S1041610211001888 [pii]
AID - 10.1017/S1041610211001888 [doi]
PST - ppublish
SO  - Int Psychogeriatr. 2012 Mar;24(3):358-66. doi: 10.1017/S1041610211001888. Epub
      2011 Oct 3.


PMID- 22014282
OWN - NLM
STAT- MEDLINE
DCOM- 20120625
LR  - 20220409
IS  - 1475-2727 (Electronic)
IS  - 1368-9800 (Linking)
VI  - 15
IP  - 3
DP  - 2012 Mar
TI  - Balancing the benefits and risks of public-private partnerships to address the
      global double burden of malnutrition.
PG  - 503-17
LID - 10.1017/S1368980011002060 [doi]
AB  - OBJECTIVE: Transnational food, beverage and restaurant companies, and their
      corporate foundations, may be potential collaborators to help address complex
      public health nutrition challenges. While UN system guidelines are available for 
      private-sector engagement, non-governmental organizations (NGO) have limited
      guidelines to navigate diverse opportunities and challenges presented by
      partnering with these companies through public-private partnerships (PPP) to
      address the global double burden of malnutrition. DESIGN: We conducted a search
      of electronic databases, UN system websites and grey literature to identify
      resources about partnerships used to address the global double burden of
      malnutrition. A narrative summary provides a synthesis of the interdisciplinary
      literature identified. RESULTS: We describe partnership opportunities, benefits
      and challenges; and tools and approaches to help NGO engage with the private
      sector to address global public health nutrition challenges. PPP benefits
      include: raising the visibility of nutrition and health on policy agendas;
      mobilizing funds and advocating for research; strengthening food-system processes
      and delivery systems; facilitating technology transfer; and expanding access to
      medications, vaccines, healthy food and beverage products, and nutrition
      assistance during humanitarian crises. PPP challenges include: balancing private 
      commercial interests with public health interests; managing conflicts of
      interest; ensuring that co-branded activities support healthy products and
      healthy eating environments; complying with ethical codes of conduct; assessing
      partnership compatibility; and evaluating partnership outcomes. CONCLUSIONS: NGO 
      should adopt a systematic and transparent approach using available tools and
      processes to maximize benefits and minimize risks of partnering with
      transnational food, beverage and restaurant companies to effectively target the
      global double burden of malnutrition.
FAU - Kraak, Vivica I
AU  - Kraak VI
AD  - WHO Collaborating Centre for Obesity Prevention, School of Health and Social
      Development, Deakin University, 221 Burwood Highway, Burwood, Victoria 3125,
      Australia. vivica.kraak@deakin.edu.au
FAU - Harrigan, Paige B
AU  - Harrigan PB
FAU - Lawrence, Mark
AU  - Lawrence M
FAU - Harrison, Paul J
AU  - Harrison PJ
FAU - Jackson, Michaela A
AU  - Jackson MA
FAU - Swinburn, Boyd
AU  - Swinburn B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111013
PL  - England
TA  - Public Health Nutr
JT  - Public health nutrition
JID - 9808463
SB  - IM
MH  - Delivery of Health Care
MH  - Diet
MH  - Food Industry
MH  - Food Supply
MH  - Global Health
MH  - Government
MH  - Guidelines as Topic
MH  - *Health Promotion
MH  - Humans
MH  - Malnutrition/*prevention & control
MH  - *Organizations
MH  - *Private Sector
MH  - *Public Health
MH  - *Public Sector
MH  - *Public-Private Sector Partnerships
MH  - Restaurants
MH  - Risk
EDAT- 2011/10/22 06:00
MHDA- 2012/06/26 06:00
CRDT- 2011/10/22 06:00
PHST- 2011/10/22 06:00 [entrez]
PHST- 2011/10/22 06:00 [pubmed]
PHST- 2012/06/26 06:00 [medline]
AID - S1368980011002060 [pii]
AID - 10.1017/S1368980011002060 [doi]
PST - ppublish
SO  - Public Health Nutr. 2012 Mar;15(3):503-17. doi: 10.1017/S1368980011002060. Epub
      2011 Oct 13.


PMID- 22014197
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20120314
IS  - 2154-4700 (Electronic)
IS  - 1933-8244 (Linking)
VI  - 66
IP  - 4
DP  - 2011
TI  - Occupational health practice and exposure to nanoparticles: reconciling
      scientific evidence, ethical aspects, and legal requirements.
PG  - 236-40
LID - 10.1080/19338244.2010.539642 [doi]
AB  - The paper aims at focusing the relationship between scientific evidence and
      ethical values' issues of occupational health practice according to the new
      Italian law 81/2008 stating that the occupational health physician (OHP) is
      required to act according to the Code of Ethics of the International Commission
      on Occupational Health. The code itself emphasizes that (i) the practice should
      be relevant, knowledge-based, sound, and appropriate to the occupational risks
      and (ii) the objectives and methods of health surveillance must be clearly
      defined. Because exposure to nanoparticles involves several uncertainties about
      health effects and may limit the effectiveness of workers' health surveillance,
      OHPs face a several ethical dilemmas, involving different stakeholders. The
      dilemmas arising from the practice should be dealt with according to the ethical 
      principles of beneficence, autonomy, and justice in order to take a decision.
FAU - Franco, Giuliano
AU  - Franco G
AD  - Department of Medicine and Medical Specialties, University of Modena and Reggio
      Emilia, School of Medicine of Modena, Modena, Italy.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Arch Environ Occup Health
JT  - Archives of environmental & occupational health
JID - 101282564
SB  - IM
MH  - Decision Making/ethics
MH  - Humans
MH  - Italy
MH  - Nanoparticles/*adverse effects
MH  - Occupational Exposure/ethics/*legislation & jurisprudence
MH  - Occupational Health/ethics/legislation & jurisprudence
MH  - Occupational Medicine/ethics/*legislation & jurisprudence
MH  - Safety Management/ethics/legislation & jurisprudence
EDAT- 2011/10/22 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/10/22 06:00
PHST- 2011/10/22 06:00 [entrez]
PHST- 2011/10/22 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - 10.1080/19338244.2010.539642 [doi]
PST - ppublish
SO  - Arch Environ Occup Health. 2011;66(4):236-40. doi: 10.1080/19338244.2010.539642.


PMID- 22013494
OWN - NLM
STAT- MEDLINE
DCOM- 20120618
LR  - 20220408
IS  - 1866-0452 (Electronic)
IS  - 1866-0452 (Linking)
VI  - 108
IP  - 39
DP  - 2011 Sep
TI  - Randomized controlled trials: part 17 of a series on evaluation of scientific
      publications.
PG  - 663-8
LID - 10.3238/arztebl.2011.0663 [doi]
AB  - BACKGROUND: In clinical research, randomized controlled trials (RCTs) are the
      best way to study the safety and efficacy of new treatments. RCTs are used to
      answer patient-related questions and are required by governmental regulatory
      bodies as the basis for approval decisions. METHODS: To help readers understand
      and evaluate RCTs, we discuss the methods and qualitative requirements of RCTs
      with reference to the literature and an illustrative case study. The discussion
      here corresponds to expositions of the subject that can be found in many
      textbooks but also reflects the authors' personal experience in planning,
      conducting and analyzing RCTs. RESULTS: The quality of an RCT depends on an
      appropriate study question and study design, the prevention of systematic errors,
      and the use of proper analytical techniques. All of these aspects must be
      attended to in the planning, conductance, analysis, and reporting of RCTs. RCTs
      must also meet ethical and legal requirements. CONCLUSION: RCTs cannot yield
      reliable data unless they are planned, conducted, analyzed, and reported in ways 
      that are methodologically sound and appropriate to the question being asked. The 
      quality of any RCT must be critically evaluated before its relevance to patient
      care can be considered.
FAU - Kabisch, Maria
AU  - Kabisch M
AD  - Interdisziplinares Zentrum Klinische Studien-IZKS, Universitatsmedizin der
      Johannes-Gutenberg-Universitat Mainz.
FAU - Ruckes, Christian
AU  - Ruckes C
FAU - Seibert-Grafe, Monika
AU  - Seibert-Grafe M
FAU - Blettner, Maria
AU  - Blettner M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110930
PL  - Germany
TA  - Dtsch Arztebl Int
JT  - Deutsches Arzteblatt international
JID - 101475967
RN  - 0 (Biomarkers)
RN  - 0 (Fibrinolytic Agents)
RN  - 9005-49-6 (Heparin)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
CIN - Dtsch Arztebl Int. 2011 Sep;108(39):661-2. PMID: 22013493
MH  - Abortion, Spontaneous
MH  - Aspirin/administration & dosage
MH  - Biomarkers
MH  - Drug Approval/*legislation & jurisprudence
MH  - Drug Therapy, Combination
MH  - Female
MH  - Fibrinolytic Agents/administration & dosage
MH  - Heparin/administration & dosage
MH  - Humans
MH  - Infant, Newborn
MH  - Live Birth
MH  - Pregnancy
MH  - Quality Control
MH  - Randomized Controlled Trials as Topic/*standards
PMC - PMC3196997
EDAT- 2011/10/21 06:00
MHDA- 2012/06/19 06:00
CRDT- 2011/10/21 06:00
PHST- 2011/02/23 00:00 [received]
PHST- 2011/06/28 00:00 [accepted]
PHST- 2011/10/21 06:00 [entrez]
PHST- 2011/10/21 06:00 [pubmed]
PHST- 2012/06/19 06:00 [medline]
AID - 10.3238/arztebl.2011.0663 [doi]
PST - ppublish
SO  - Dtsch Arztebl Int. 2011 Sep;108(39):663-8. doi: 10.3238/arztebl.2011.0663. Epub
      2011 Sep 30.


PMID- 22013421
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1663-9812 (Electronic)
IS  - 1663-9812 (Linking)
VI  - 2
DP  - 2011
TI  - Valorising and creating access to innovative medicines in the European union.
PG  - 57
LID - 10.3389/fphar.2011.00057 [doi]
AB  - This Perspective describes (a) the current situation, (b) challenges and
      initiatives, (c) and formulates recommendations to valorize and create access to 
      innovative medicines in the EU. We are currently still far away from optimal
      assessment of value for money in the EU. On the one hand, valorizing innovative
      medicines involves a local appraisal by health technology assessment (HTA) bodies
      and competent authorities about the value for money, the budget impact, and the
      local medical need that can be filled with new medicines. Therefore, local
      priorities and national health care policy environments should be reflected in
      the processes and criteria used for assessing value for money and ultimately for 
      reimbursement decisions. On the other hand, a pan-European assessment of both
      relative effectiveness and medical need (including general ethical and social
      considerations) should be envisaged in order to feed part of the data needed for 
      the local decisions in an efficient way. This could be the task of the European
      Medicines Agency, HTA bodies, and competent authorities together.
FAU - Annemans, Lieven
AU  - Annemans L
AD  - Center for Health Economics, Department of Public Health, Ghent University Ghent,
      Belgium.
FAU - Cleemput, Irina
AU  - Cleemput I
FAU - Hulstaert, Frank
AU  - Hulstaert F
FAU - Simoens, Steven
AU  - Simoens S
LA  - eng
PT  - Journal Article
DEP - 20111011
PL  - Switzerland
TA  - Front Pharmacol
JT  - Frontiers in pharmacology
JID - 101548923
PMC - PMC3190181
OTO - NOTNLM
OT  - access
OT  - budget impact
OT  - cost-effectiveness
OT  - health technology assessment
OT  - medical need
OT  - pharmaceutical innovation
OT  - relative effectiveness
EDAT- 2011/10/21 06:00
MHDA- 2011/10/21 06:01
CRDT- 2011/10/21 06:00
PHST- 2011/06/28 00:00 [received]
PHST- 2011/09/18 00:00 [accepted]
PHST- 2011/10/21 06:00 [entrez]
PHST- 2011/10/21 06:00 [pubmed]
PHST- 2011/10/21 06:01 [medline]
AID - 10.3389/fphar.2011.00057 [doi]
PST - epublish
SO  - Front Pharmacol. 2011 Oct 11;2:57. doi: 10.3389/fphar.2011.00057. eCollection
      2011.


PMID- 22013171
OWN - NLM
STAT- MEDLINE
DCOM- 20120227
LR  - 20211020
IS  - 1740-7753 (Electronic)
IS  - 1740-7745 (Linking)
VI  - 8
IP  - 5
DP  - 2011 Oct
TI  - Design of a randomized trial of diabetes genetic risk testing to motivate
      behavior change: the Genetic Counseling/lifestyle Change (GC/LC) Study for
      Diabetes Prevention.
PG  - 609-15
LID - 10.1177/1740774511414159 [doi]
AB  - BACKGROUND: The efficacy of diabetes genetic risk testing to motivate behavior
      change for diabetes prevention is currently unknown. PURPOSE: This paper presents
      key issues in the design and implementation of one of the first randomized trials
      (The Genetic Counseling/Lifestyle Change (GC/LC) Study for Diabetes Prevention)
      to test whether knowledge of diabetes genetic risk can motivate patients to adopt
      healthier behaviors. METHODS: Because individuals may react differently to
      receiving 'higher' vs 'lower' genetic risk results, we designed a 3-arm parallel 
      group study to separately test the hypotheses that: (1) patients receiving
      'higher' diabetes genetic risk results will increase healthy behaviors compared
      to untested controls, and (2) patients receiving 'lower' diabetes genetic risk
      results will decrease healthy behaviors compared to untested controls. In this
      paper we describe several challenges to implementing this study, including: (1)
      the application of a novel diabetes risk score derived from genetic epidemiology 
      studies to a clinical population, (2) the use of the principle of Mendelian
      randomization to efficiently exclude 'average' diabetes genetic risk patients
      from the intervention, and (3) the development of a diabetes genetic risk
      counseling intervention that maintained the ethical need to motivate behavior
      change in both 'higher' and 'lower' diabetes genetic risk result recipients.
      RESULTS: Diabetes genetic risk scores were developed by aggregating the results
      of 36 diabetes-associated single nucleotide polymorphisms. Relative risk for type
      2 diabetes was calculated using Framingham Offspring Study outcomes, grouped by
      quartiles into 'higher', 'average' (middle two quartiles) and 'lower' genetic
      risk. From these relative risks, revised absolute risks were estimated using the 
      overall absolute risk for the study group. For study efficiency, we excluded all 
      patients receiving 'average' diabetes risk results from the subsequent
      intervention. This post-randomization allocation strategy was justified because
      genotype represents a random allocation of parental alleles ('Mendelian
      randomization'). Finally, because it would be unethical to discourage
      participants to participate in diabetes prevention behaviors, we designed our two
      diabetes genetic risk counseling interventions (for 'higher' and 'lower' result
      recipients) so that both groups would be motivated despite receiving opposing
      results. LIMITATIONS: For this initial assessment of the clinical implementation 
      of genetic risk testing we assessed intermediate outcomes of attendance at a
      12-week diabetes prevention course and changes in self-reported motivation. If
      effective, longer term studies with larger sample sizes will be needed to assess 
      whether knowledge of diabetes genetic risk can help patients prevent diabetes.
      CONCLUSIONS: We designed a randomized clinical trial designed to explore the
      motivational impact of disclosing both higher than average and lower than average
      genetic risk for type 2 diabetes. This design allowed exploration of both
      increased risk and false reassurance, and has implications for future studies in 
      translational genomics.
FAU - Grant, Richard W
AU  - Grant RW
AD  - Division of General Medicine, Massachusetts General Hospital, Boston, MA, USA.
      Rgrant@partners.org
FAU - Meigs, James B
AU  - Meigs JB
FAU - Florez, Jose C
AU  - Florez JC
FAU - Park, Elyse R
AU  - Park ER
FAU - Green, Robert C
AU  - Green RC
FAU - Waxler, Jessica L
AU  - Waxler JL
FAU - Delahanty, Linda M
AU  - Delahanty LM
FAU - O'Brien, Kelsey E
AU  - O'Brien KE
LA  - eng
GR  - R21 DK084527/DK/NIDDK NIH HHS/United States
GR  - R21 DK84527-01/DK/NIDDK NIH HHS/United States
GR  - K24 AG027841/AG/NIA NIH HHS/United States
GR  - K24 DK080140/DK/NIDDK NIH HHS/United States
GR  - R01 HG002213/HG/NHGRI NIH HHS/United States
GR  - NCT01034319/PHS HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - Clin Trials
JT  - Clinical trials (London, England)
JID - 101197451
SB  - IM
MH  - Diabetes Mellitus, Type 2/*genetics/*prevention & control
MH  - Directive Counseling
MH  - Female
MH  - Genetic Counseling
MH  - Genetic Testing
MH  - *Health Behavior
MH  - Health Care Surveys
MH  - Health Knowledge, Attitudes, Practice
MH  - Health Promotion/methods
MH  - Humans
MH  - Interview, Psychological/methods
MH  - Life Style
MH  - Male
MH  - *Motivation
MH  - Polymorphism, Single Nucleotide
MH  - *Research Design
MH  - Risk Assessment/methods
MH  - Sample Size
MH  - Social Marketing
PMC - PMC3763721
MID - NIHMS498086
EDAT- 2011/10/21 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/10/21 06:00
PHST- 2011/10/21 06:00 [entrez]
PHST- 2011/10/21 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - 8/5/609 [pii]
AID - 10.1177/1740774511414159 [doi]
PST - ppublish
SO  - Clin Trials. 2011 Oct;8(5):609-15. doi: 10.1177/1740774511414159.


PMID- 22013138
OWN - NLM
STAT- MEDLINE
DCOM- 20120213
LR  - 20111020
IS  - 1092-874X (Electronic)
IS  - 1091-5818 (Linking)
VI  - 30
IP  - 5
DP  - 2011 Oct
TI  - Considerations regarding nonhuman primate use in safety assessment of
      biopharmaceuticals.
PG  - 583-90
LID - 10.1177/1091581811415875 [doi]
AB  - Selection of a pharmacologically responsive species can represent a major
      challenge in designing nonclinical safety assessment programs for many
      biopharmaceuticals (eg, monoclonal antibodies (mAbs)). Frequently, the only
      relevant species for nonclinical testing of mAbs is the non-human primate (NHP). 
      This situation, coupled with a rapidly increasing number of mAb drugs in
      development, has resulted in a significant increase in the number of NHPs used in
      nonclinical safety assessment. Apart from ethical considerations related to
      responsible animal use, there is a clear need for more efficient and innovative
      approaches to drug discovery and development; these factors drive the need to
      investigate alternative approaches and strategies for the safety assessment. This
      review summarizes important scientific and regulatory perspectives derived from
      presentations and audience discussions in an educational forum at the 2010 annual
      American College of Toxicology meeting regarding opportunities for employing
      alternative approaches to minimize NHP use in mAb drug development.
FAU - Buckley, Lorrene A
AU  - Buckley LA
AD  - Eli Lilly and Co., Indianapolis, IN 46225, USA. buckleyla@lilly.com
FAU - Chapman, Kathryn
AU  - Chapman K
FAU - Burns-Naas, Leigh Ann
AU  - Burns-Naas LA
FAU - Todd, Marque D
AU  - Todd MD
FAU - Martin, Pauline L
AU  - Martin PL
FAU - Lansita, Janice A
AU  - Lansita JA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Int J Toxicol
JT  - International journal of toxicology
JID - 9708436
RN  - 0 (Antibodies, Monoclonal)
SB  - IM
MH  - *Animal Experimentation/ethics
MH  - *Animal Use Alternatives
MH  - Animals
MH  - Antibodies, Monoclonal/administration & dosage/adverse effects
MH  - Biotechnology/methods
MH  - Drug Discovery/*methods
MH  - Drug Evaluation, Preclinical/*methods
MH  - Drug Industry
MH  - Guidelines as Topic
MH  - Humans
MH  - Primates
MH  - Program Development
MH  - Risk Assessment
MH  - Toxicity Tests/*methods
EDAT- 2011/10/21 06:00
MHDA- 2012/02/14 06:00
CRDT- 2011/10/21 06:00
PHST- 2011/10/21 06:00 [entrez]
PHST- 2011/10/21 06:00 [pubmed]
PHST- 2012/02/14 06:00 [medline]
AID - 30/5/583 [pii]
AID - 10.1177/1091581811415875 [doi]
PST - ppublish
SO  - Int J Toxicol. 2011 Oct;30(5):583-90. doi: 10.1177/1091581811415875.


PMID- 22012905
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20111020
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 261
IP  - 2
DP  - 2011 Nov
TI  - Percutaneous transluminal angioplasty versus turbostatic carbon-coated stents in 
      infrapopliteal arteries: InPeria II trial.
PG  - 634-42
LID - 10.1148/radiol.11101357 [doi]
AB  - PURPOSE: To determine the clinical outcome and the success of stent application
      for high-grade lesions of the infrapopliteal arteries compared with treatment
      with percutaneous transluminal angioplasty (PTA) in critical limb ischemia (CLI).
      MATERIALS AND METHODS: In this ethics board-approved randomized prospective
      study, PTA or stent application was performed on 131 lesions in 88 patients with 
      CLI. The primary end points were clinical improvement after endovascular
      treatment and limb salvage rate. Secondary end points were defined by the minimal
      lumen diameter (MLD) before and after the revascularization procedure, percentage
      of residual diameter stenosis (DS), binary restenosis rate (>50% DS and >70% DS),
      and incidence of target lesion revascularization at 9-month follow-up. RESULTS:
      At 3 months, the clinical status in the PTA group was less improved than that in 
      the stent group (P = .008). At 9 months, there had been five minor and two major 
      amputations in the PTA group and five major and five minor amputations in the
      stent group. MLD was significantly larger and the percentage of DS was
      significantly less in the stent group at completion angiography. At 9 months, the
      angiographic control showed better trends for the stent group in comparison to
      the PTA group despite that no significant differences were detected (MLD, 1.19 mm
      +/- 0.92 vs 1.02 mm +/- 1.02; DS, 38.68% +/- 25.47 vs 43.31% +/- 28.37).
      CONCLUSION: Infrapopliteal stent application is an effective treatment modality
      in CLI. The PTA and stent groups were essentially equal at 3 and 9 months except 
      for the difference in clinical improvement in the stent group at 3 months.
CI  - RSNA, 2011
FAU - Rand, Thomas
AU  - Rand T
AD  - Department of Radiology, General Hospital Hietzing, Wolkersbergenstr. 1, 1130
      Vienna, Austria. Thomas.Rand@wienkav.at
FAU - Lammer, Johannes
AU  - Lammer J
FAU - Rabbia, Claudio
AU  - Rabbia C
FAU - Maynar, Manuel
AU  - Maynar M
FAU - Zander, Tobias
AU  - Zander T
FAU - Jahnke, Thomas
AU  - Jahnke T
FAU - Muller-Hulsbeck, Stefan
AU  - Muller-Hulsbeck S
FAU - Scheinert, Dierk
AU  - Scheinert D
FAU - Manninen, Hannu I
AU  - Manninen HI
LA  - eng
PT  - Clinical Trial, Phase II
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Coated Materials, Biocompatible)
RN  - 7440-44-0 (Carbon)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Angioplasty/*methods
MH  - Carbon
MH  - Chi-Square Distribution
MH  - Coated Materials, Biocompatible
MH  - Europe
MH  - Female
MH  - Humans
MH  - Ischemia/*therapy
MH  - Leg/*blood supply
MH  - Limb Salvage
MH  - Male
MH  - Middle Aged
MH  - *Popliteal Artery
MH  - Prospective Studies
MH  - *Stents
MH  - Treatment Outcome
EDAT- 2011/10/21 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/10/21 06:00
PHST- 2011/10/21 06:00 [entrez]
PHST- 2011/10/21 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 261/2/634 [pii]
AID - 10.1148/radiol.11101357 [doi]
PST - ppublish
SO  - Radiology. 2011 Nov;261(2):634-42. doi: 10.1148/radiol.11101357.


PMID- 22012772
OWN - NLM
STAT- MEDLINE
DCOM- 20111206
LR  - 20151119
IS  - 1930-7837 (Electronic)
IS  - 0022-0337 (Linking)
VI  - 75
IP  - 10
DP  - 2011 Oct
TI  - The status of ethics teaching and learning in U.S. dental schools.
PG  - 1295-309
AB  - The purpose of this study was to gather and analyze information about the status 
      of ethics teaching and learning in U.S. dental schools and to recommend a
      curriculum development and research agenda for professional ethics in dental
      education. A survey to collect this information was developed by the authors and 
      administered by the American Society for Dental Ethics. The results suggest that 
      dental schools have adopted many of the recommendations for curricular content
      and learning strategies proposed in the 1989 American Association of Dental
      Schools (now American Dental Education Association) Curriculum Guidelines on
      Ethics and Professionalism in Dentistry. The survey was sent to the individual
      who directs the ethics curriculum at the fifty-six U.S. dental schools that had a
      full complement of enrolled predoctoral classes as of January 2008. All fifty-six
      schools responded to the survey. The data suggest that, in general, little time
      is devoted to ethics instruction in the formal curriculum. The mean number of
      contact hours of ethics instruction is 26.5 hours, which represents about 0.5
      percent of the mean clock hours of instruction for dental education programs
      reported in the most recent American Dental Association survey of dental
      education. While the amount of time devoted to ethics instruction appears not to 
      have changed much over the past thirty years, what has changed are what qualifies
      as ethics instruction, the pedagogies used, and the development and availability 
      of norm-referenced learning outcomes assessments, which are currently used by a
      number of schools. We found that dental schools address a substantial list of
      topics in their ethics instruction and that there is general agreement as to the 
      appropriateness of the topics and the ethics competencies that need to be
      developed and assessed. This study also identified the respondents' perceptions
      of unmet needs in ethics education. Four general themes emerged: the need for
      ethics to be more fully integrated across the curriculum, including carryover
      into the clinical years; the need to assess and ensure competence; the need for
      faculty development; and the need for more attention to method of instruction.
      Recommendations based on the study findings are offered for a curriculum
      development and research agenda for professional ethics in dental education.
FAU - Lantz, Marilyn S
AU  - Lantz MS
AD  - School of Dentistry, University of Michigan, Ann Arbor, MI 48109-1078, USA.
      mslantz@umich.edu
FAU - Bebeau, Muriel J
AU  - Bebeau MJ
FAU - Zarkowski, Pamela
AU  - Zarkowski P
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Dent Educ
JT  - Journal of dental education
JID - 8000150
SB  - IM
MH  - *Curriculum
MH  - Dental Research/education
MH  - Educational Measurement/methods
MH  - Ethics, Dental/*education
MH  - Humans
MH  - Learning
MH  - Needs Assessment
MH  - *Schools, Dental
MH  - Staff Development
MH  - Surveys and Questionnaires
MH  - Teaching/methods
MH  - United States
EDAT- 2011/10/21 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/10/21 06:00
PHST- 2011/10/21 06:00 [entrez]
PHST- 2011/10/21 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 75/10/1295 [pii]
PST - ppublish
SO  - J Dent Educ. 2011 Oct;75(10):1295-309.


PMID- 22012372
OWN - NLM
STAT- MEDLINE
DCOM- 20111027
LR  - 20211020
IS  - 1476-4687 (Electronic)
IS  - 0028-0836 (Linking)
VI  - 478
IP  - 7369
DP  - 2011 Oct 19
TI  - Research ethics: Treat donors as partners in biobank research.
PG  - 312-3
LID - 10.1038/478312a [doi]
FAU - Saha, Krishanu
AU  - Saha K
AD  - Technology and Society, Harvard Kennedy School, Cambridge, Massachusetts 02138,
      USA. saha@wi.mit.edu
FAU - Hurlbut, J Benjamin
AU  - Hurlbut JB
LA  - eng
PT  - Journal Article
DEP - 20111019
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
SB  - IM
CIN - Nature. 2012 Jan 26;481(7382):443. PMID: 22281584
MH  - Biological Specimen Banks/legislation & jurisprudence
MH  - *Ethics, Research
MH  - Humans
MH  - Organizational Policy
MH  - Public-Private Sector Partnerships
MH  - *Research Subjects/legislation & jurisprudence
EDAT- 2011/10/21 06:00
MHDA- 2011/10/28 06:00
CRDT- 2011/10/21 06:00
PHST- 2011/10/21 06:00 [entrez]
PHST- 2011/10/21 06:00 [pubmed]
PHST- 2011/10/28 06:00 [medline]
AID - 478312a [pii]
AID - 10.1038/478312a [doi]
PST - epublish
SO  - Nature. 2011 Oct 19;478(7369):312-3. doi: 10.1038/478312a.


PMID- 22012290
OWN - NLM
STAT- MEDLINE
DCOM- 20120307
LR  - 20160815
IS  - 1806-9282 (Electronic)
IS  - 0104-4230 (Linking)
VI  - 57
IP  - 5
DP  - 2011 Sep-Oct
TI  - Anemia-associated factors in infants born at term with normal weight.
PG  - 550-8
LID - S0104-42302011000500014 [pii]
AB  - OBJECTIVE: To investigate the factors involved in the genesis of infant iron
      deficiency anemia. METHODS: This is a cross-sectional study, which evaluated 104 
      children in their second year of life who were born at term with adequate weight 
      in Vicosa, Minas Gerais, Brazil. An interview, a 24-hour recall to parents, and
      anthropometric assessment were used. Laboratory exams included blood count,
      ferritin, and serum retinol. This study was approved by the Ethics Committee of
      UFMG and UFV. Statistical analyses were conducted using the Epi Info and SPSS
      softwares. Poisson generalized linear regression model was used to determine the 
      association of anemia with the study variables, with results expressed as
      prevalence ratio. RESULTS: Vitamin A deficiency and anemia were identified in
      9.6% e 26% of the children, respectively. Infant anemia was associated with the
      date of onset of prenatal care, maternal use of iron after childbirth, paternal
      working status, prior use of iron by the child, and duration of breastfeeding.
      Thus, in the second year of life, lactating children of women who began prenatal 
      care late and did not use iron compounds after birth, with unemployed parents,
      who never received iron compounds, and who were predominantly breastfed for more 
      than four months had significantly higher prevalence of anemia. CONCLUSION: The
      results have demonstrated the importance of nutrition during pregnancy and
      infancy in the prevention of anemia in children.
FAU - Netto, Michele Pereira
AU  - Netto MP
AD  - Universidade Federal de Juiz de Fora, Juiz de Fora, MG, Brazil.
FAU - Rocha, Daniela da Silva
AU  - Rocha Dda S
FAU - Franceschini, Sylvia do Carmo Castro
AU  - Franceschini Sdo C
FAU - Lamounier, Joel Alves
AU  - Lamounier JA
LA  - eng
LA  - por
PT  - Journal Article
PL  - Brazil
TA  - Rev Assoc Med Bras (1992)
JT  - Revista da Associacao Medica Brasileira (1992)
JID - 9308586
SB  - IM
MH  - Anemia, Iron-Deficiency/epidemiology/*etiology
MH  - Brazil/epidemiology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Postnatal Care
MH  - Prenatal Care
MH  - Prevalence
MH  - Risk Factors
MH  - Socioeconomic Factors
MH  - *Term Birth
EDAT- 2011/10/21 06:00
MHDA- 2012/03/08 06:00
CRDT- 2011/10/21 06:00
PHST- 2011/03/25 00:00 [received]
PHST- 2011/06/27 00:00 [accepted]
PHST- 2011/10/21 06:00 [entrez]
PHST- 2011/10/21 06:00 [pubmed]
PHST- 2012/03/08 06:00 [medline]
AID - S0104-42302011000500014 [pii]
PST - ppublish
SO  - Rev Assoc Med Bras (1992). 2011 Sep-Oct;57(5):550-8.


PMID- 22012278
OWN - NLM
STAT- MEDLINE
DCOM- 20120307
LR  - 20190918
IS  - 1806-9282 (Electronic)
IS  - 0104-4230 (Linking)
VI  - 57
IP  - 5
DP  - 2011 Sep-Oct
TI  - Ethical issues on experiments in anima nobile on hepatitis.
PG  - 488-94
LID - S0104-42302011000500002 [pii]
FAU - Gaze, Rosangela
AU  - Gaze R
AD  - Instituto de Estudos de Saude Coletiva, History, Health and Society Laboratory,
      Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
      rosangelagaze@gmail.com
FAU - Carvalho, Diana Maul de
AU  - Carvalho DM
FAU - Tura, Luiz Fernando Rangel
AU  - Tura LF
FAU - Silva, Carolina Carvalho Serres da
AU  - Silva CC
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - Brazil
TA  - Rev Assoc Med Bras (1992)
JT  - Revista da Associacao Medica Brasileira (1992)
JID - 9308586
SB  - IM
MH  - Ethics, Research/*history
MH  - Hepatitis, Viral, Human/*history
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Human Experimentation/ethics/history
MH  - Humans
MH  - Informed Consent/ethics/*history
EDAT- 2011/10/21 06:00
MHDA- 2012/03/08 06:00
CRDT- 2011/10/21 06:00
PHST- 2011/10/21 06:00 [entrez]
PHST- 2011/10/21 06:00 [pubmed]
PHST- 2012/03/08 06:00 [medline]
AID - S0104-42302011000500002 [pii]
AID - 10.1590/s0104-42302011000500002 [doi]
PST - ppublish
SO  - Rev Assoc Med Bras (1992). 2011 Sep-Oct;57(5):488-94. doi:
      10.1590/s0104-42302011000500002.


PMID- 22012097
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140610
LR  - 20191112
IS  - 1678-4758 (Electronic)
IS  - 0104-5970 (Linking)
VI  - 18
IP  - 3
DP  - 2011
TI  - [Nature and culture in the eyes of a nineteenth-century naturalist: Wallace and
      the Amazon].
PG  - 775-88
LID - S0104-59702011000300010 [pii]
AB  - Alfred Russel Wallace traveled through the Amazon from 1848 to 1852. His
      perceptions of the region were informed by his systematized knowledge but also
      influenced by judgments of an ethical and aesthetic nature, as was common among
      naturalists. He saw the region's 'natives' as peaceful and friendly but likewise 
      susceptible to the vices of civilization. Nature afforded a privileged setting
      both for the activities of natural history and for aesthetic pleasures. These
      features helped keep the naturalist in the region, where he could thus engage in 
      his scientific activities.
FAU - Alves, Jose Jeronimo de Alencar
AU  - Alves JJ
AD  - Instituto de Educacao Matematica e Cientifica, Universidade Federal do Para,
      Belem, PA, Brasil, 66053-040. jeronimoalves@hotmail.com
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - A natureza e a cultura no compasso de um naturalista do seculo XIX: Wallace e a
      Amazonia.
PL  - Brazil
TA  - Hist Cienc Saude Manguinhos
JT  - Historia, ciencias, saude--Manguinhos
JID - 9513999
EDAT- 2011/10/21 06:00
MHDA- 2011/10/21 06:01
CRDT- 2011/10/21 06:00
PHST- 2010/09/01 00:00 [received]
PHST- 2011/06/01 00:00 [accepted]
PHST- 2011/10/21 06:00 [entrez]
PHST- 2011/10/21 06:00 [pubmed]
PHST- 2011/10/21 06:01 [medline]
AID - S0104-59702011000300010 [pii]
AID - 10.1590/s0104-59702011000300010 [doi]
PST - ppublish
SO  - Hist Cienc Saude Manguinhos. 2011;18(3):775-88. doi:
      10.1590/s0104-59702011000300010.


PMID- 22011972
OWN - NLM
STAT- MEDLINE
DCOM- 20130517
LR  - 20151119
IS  - 1472-0213 (Electronic)
IS  - 1472-0205 (Linking)
VI  - 29
IP  - 9
DP  - 2012 Sep
TI  - Emergency clinicians' attitudes and decisions in patient scenarios involving
      advance directives.
PG  - 720-4
LID - 10.1136/emermed-2011-200287 [doi]
AB  - INTRODUCTION: To identify the decisions and attitudes of emergency clinicians in 
      hypothetical scenarios involving advance directives (ADs). METHODS: An online
      survey distributed to members of the Australasian College for Emergency Medicine 
      elicited decisions on commencing full treatment (CFT), limiting treatment or
      palliation in hypothetical clinical scenarios. Quantitative data were summarised 
      using number and percentage. RESULTS: 388 surveys yielded a 13.0% response rate, 
      including 190 fellows (51.9%) and 176 trainees (48.1%). For a 75-year-old patient
      with major trauma and unknown comorbidities requiring laparotomy, most
      participants (355/365, 97.3%) chose CFT. When an AD limiting treatment was made
      available, CFT decreased substantially (63/364, 17.3%), and the modal response
      was palliation (175/364, 48.1%). The most frequently reported influential factor 
      in this decision was ethical obligation (82/383, 21.4%). For an elderly
      nursing-home resident with dementia, metastatic cancer and possible septic shock,
      10.7% (39/366) chose CFT, changing little (21/365, 5.8%) with a directive
      requesting full treatment. The patient's presentation and history (189/375,
      50.4%) overrode legal obligations (14/375, 3.7%) in influencing the decision. For
      a 55-year-old man with prostate cancer, hypoxia and acute respiratory distress
      (potentially requiring ventilatory support) saying, 'I just want to end it all,' 
      most (233/366, 63.7%) chose CFT. A directive requesting limitation resulted in
      fewer decisions on CFT (43/368, 11.7%). Clear documentation was most important
      (100/362, 27.6%) in influencing this decision. CONCLUSION: Hypothetical treatment
      decisions involving ADs made by emergency clinicians appear to be more influenced
      by ethical and clinical factors than by legal obligations.
FAU - Wong, Rebecca E
AU  - Wong RE
AD  - Emergency Practice Innovation Centre, St Vincent's Hospital, 41 Victoria Pde,
      Fitzroy 3065, Melbourne, Victoria, Australia.
FAU - Weiland, Tracey J
AU  - Weiland TJ
FAU - Jelinek, George A
AU  - Jelinek GA
LA  - eng
PT  - Journal Article
DEP - 20111019
PL  - England
TA  - Emerg Med J
JT  - Emergency medicine journal : EMJ
JID - 100963089
SB  - IM
MH  - Adult
MH  - Advance Directives/*psychology
MH  - Aged
MH  - *Attitude of Health Personnel
MH  - Australasia
MH  - Clinical Competence
MH  - Decision Making
MH  - *Emergency Medicine
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Physicians/*psychology
MH  - Referral and Consultation
MH  - Resuscitation Orders/*psychology
MH  - Surveys and Questionnaires
EDAT- 2011/10/21 06:00
MHDA- 2013/05/18 06:00
CRDT- 2011/10/21 06:00
PHST- 2011/10/21 06:00 [entrez]
PHST- 2011/10/21 06:00 [pubmed]
PHST- 2013/05/18 06:00 [medline]
AID - emermed-2011-200287 [pii]
AID - 10.1136/emermed-2011-200287 [doi]
PST - ppublish
SO  - Emerg Med J. 2012 Sep;29(9):720-4. doi: 10.1136/emermed-2011-200287. Epub 2011
      Oct 19.


PMID- 22011926
OWN - NLM
STAT- MEDLINE
DCOM- 20120118
LR  - 20151119
IS  - 0209-1712 (Print)
IS  - 0209-1712 (Linking)
VI  - 43
IP  - 3
DP  - 2011 Jul-Sep
TI  - [The ethics of resuscitation].
PG  - 190-6
AB  - Resuscitation should always be attempted in a patient who has at least a
      theoretical chance of survival. This assumes that there are patent cerebral,
      coronary and pulmonary vessels, a reasonable time from cardiac arrest has not
      been exceeded, and cardiac arrest did not occur as a result of a terminal
      condition caused by an untreatable disease. During resuscitation, medical
      personnel may face two dilemmas: when to start CPR, and when (and how) to stop
      it. Apart from various medical conditions, possible outcome and will of a victim 
      has to be taken into consideration. CPR is frequently started without an adequate
      knowledge of the patient's medical status. As soon as the latter is obtained, a
      decision about continuing CPR should be reconsidered. CPR and/or life-prolonging 
      treatment can be stopped in several situations, i.e. lack of cardiovascular
      response or recognition of a life-limiting condition. The decision should be made
      by a team leader, acting in accordance with national or house guidelines. In
      terminal patients, a DNR order should be issued well in advance, usually by an
      attending physician. After that, the patient should be provided with palliative
      care, consisting of pain therapy, and treatment of dyspnoea, congestive cardiac
      failure, etc. In their review, the authors discuss various medical and ethical
      aspects of resuscitation, concluding that hospital ethics committees could be of 
      great value in solving complicated questions relating to limitation of
      resuscitation and life-prolonging treatment.
FAU - Rudnicka-Drozak, Ewa
AU  - Rudnicka-Drozak E
AD  - Emergency Medicine Unit, Medical University of Lublin.
FAU - Aftyka, Anna
AU  - Aftyka A
LA  - pol
PT  - English Abstract
PT  - Journal Article
TT  - Eytka resuscytacji.
PL  - Poland
TA  - Anestezjol Intens Ter
JT  - Anestezjologia intensywna terapia
JID - 9424972
SB  - IM
CIN - Anaesthesiol Intensive Ther. 2012 Jan-Mar;44(1):51. PMID: 23801515
CIN - Anaesthesiol Intensive Ther. 2012 Jan-Mar;44(1):52-3. PMID: 23801516
MH  - Cardiopulmonary Resuscitation/*ethics/standards
MH  - Critical Care/*ethics
MH  - Emergency Medical Services/*ethics/standards
MH  - Ethics, Medical
MH  - First Aid/ethics
MH  - Heart Arrest/*therapy
MH  - Humans
MH  - Resuscitation Orders/ethics
EDAT- 2011/10/21 06:00
MHDA- 2012/01/19 06:00
CRDT- 2011/10/21 06:00
PHST- 2011/10/21 06:00 [entrez]
PHST- 2011/10/21 06:00 [pubmed]
PHST- 2012/01/19 06:00 [medline]
PST - ppublish
SO  - Anestezjol Intens Ter. 2011 Jul-Sep;43(3):190-6.


PMID- 22011326
OWN - NLM
STAT- MEDLINE
DCOM- 20120320
LR  - 20130520
IS  - 1440-1665 (Electronic)
IS  - 1039-8562 (Linking)
VI  - 19
IP  - 6
DP  - 2011 Dec
TI  - The conflict between accountability and confidentiality in Medicare's access to
      psychiatrists? notes.
PG  - 489-92
LID - 10.3109/10398562.2011.610460 [doi]
AB  - OBJECTIVE: The aims of this paper were to identify a conflict between
      psychiatrists? obligations regarding patient confidentiality and Medicare's
      auditing procedures, and to examine potential resolutions to the conflict.
      CONCLUSION: While it is reasonable for Medicare, as a taxpayer-funded
      instrumentality, to require documentary evidence to substantiate and justify
      claims, such a requirement constitutes a significant breach of patient
      confidentiality. Obtaining patient consent appears to be the only ethical
      resolution of the issue.
FAU - Jewell, Paul
AU  - Jewell P
AD  - Disability and Community Inclusion, School of Medicine, Flinders University,
      Adelaide, South Australia, Australia. Paul.Jewell@fl inders.edu.au
LA  - eng
PT  - Journal Article
DEP - 20111020
PL  - England
TA  - Australas Psychiatry
JT  - Australasian psychiatry : bulletin of Royal Australian and New Zealand College of
      Psychiatrists
JID - 9613603
SB  - IM
CIN - Australas Psychiatry. 2012 Jun;20(3):252. PMID: 22767943
MH  - Australia
MH  - Confidentiality/*ethics
MH  - Ethics, Medical
MH  - Humans
MH  - Informed Consent/ethics
MH  - National Health Programs/*ethics/legislation & jurisprudence
MH  - *Social Responsibility
EDAT- 2011/10/21 06:00
MHDA- 2012/03/21 06:00
CRDT- 2011/10/21 06:00
PHST- 2011/10/21 06:00 [entrez]
PHST- 2011/10/21 06:00 [pubmed]
PHST- 2012/03/21 06:00 [medline]
AID - 10.3109/10398562.2011.610460 [doi]
PST - ppublish
SO  - Australas Psychiatry. 2011 Dec;19(6):489-92. doi: 10.3109/10398562.2011.610460.
      Epub 2011 Oct 20.


PMID- 22011278
OWN - NLM
STAT- MEDLINE
DCOM- 20120625
LR  - 20111201
IS  - 1557-9034 (Electronic)
IS  - 1092-6429 (Linking)
VI  - 21
IP  - 10
DP  - 2011 Dec
TI  - Laparoscopic animal surgery for training without sacrificing animals; introducing
      the rabbit as a model for infantile laparoscopy.
PG  - 929-33
LID - 10.1089/lap.2011.0308 [doi]
AB  - INTRODUCTION: Improvement in laparoscopic skills requires practicing, and it is
      mostly beneficial when live animal models are considered for use. Apart from
      pelvic trainer, dogs and rabbits are used as the animal models for training
      laparoscopic surgeries at our center. Every effort is made to keep the animals
      alive after surgery. MATERIALS AND METHODS: From January 2007 to January 2010,
      German shepherd dogs and Angora rabbits were selected as the animal models for
      laparoscopic skill training. Under general anesthesia, trainees performed several
      laparoscopic surgeries under the supervision of experienced surgeons. RESULTS: A 
      total number of 72 animals including 54 dogs and 18 rabbits were used for
      training laparoscopy. In total, some 107 different laparoscopic procedures were
      performed by trainees including nephrectomy, nephropexy, vesicotomy and
      vesicorrhaphy, vasectomies, spermatic cord ligation, and unilateral oophrectomy. 
      There were one vascular and two visceral injuries in the rabbit model that were
      laparoscopically controlled, and conversion to open surgery happened in one case 
      due to the failure in extracting the specimen from the abdominal cavity. Three
      visceral and six vascular injuries occurred in the canine model. Total mortality 
      was five including three rabbits and two dogs. CONCLUSIONS: The sacrifice of the 
      animal is important to be avoided from both ethical and technical stand points.
      Dogs and rabbits are good models for laparoscopic training in urology, and it is 
      possible to keep the animals alive after surgery by close monitoring. We also
      found the rabbit to be a good model for practicing infantile laparoscopic
      surgery, as it simulates the real surgery in this difficult age group.
FAU - Simforoosh, Nasser
AU  - Simforoosh N
AD  - Shahid Labbafinejad Medical Center, Urology and Nephrology Research Center,
      Shahid Beheshti University, M.C., Tehran, Islamic Republic of Iran.
      simforoosh@iurtc.org.ir
FAU - Khazaeli, Mahziar
AU  - Khazaeli M
FAU - Nouralizadeh, Akbar
AU  - Nouralizadeh A
FAU - Soltani, Mohammad Hossein
AU  - Soltani MH
FAU - Samzadeh, Mohammad
AU  - Samzadeh M
FAU - Saffarian, Omid
AU  - Saffarian O
FAU - Rahmani, Jalaleddin
AU  - Rahmani J
LA  - eng
PT  - Journal Article
DEP - 20111019
PL  - United States
TA  - J Laparoendosc Adv Surg Tech A
JT  - Journal of laparoendoscopic & advanced surgical techniques. Part A
JID - 9706293
SB  - IM
MH  - Animals
MH  - Dogs
MH  - Female
MH  - Laparoscopy/*education
MH  - Male
MH  - *Models, Animal
MH  - Rabbits
EDAT- 2011/10/21 06:00
MHDA- 2012/06/26 06:00
CRDT- 2011/10/21 06:00
PHST- 2011/10/21 06:00 [entrez]
PHST- 2011/10/21 06:00 [pubmed]
PHST- 2012/06/26 06:00 [medline]
AID - 10.1089/lap.2011.0308 [doi]
PST - ppublish
SO  - J Laparoendosc Adv Surg Tech A. 2011 Dec;21(10):929-33. doi:
      10.1089/lap.2011.0308. Epub 2011 Oct 19.


PMID- 22011068
OWN - NLM
STAT- MEDLINE
DCOM- 20120223
LR  - 20211020
IS  - 1545-5815 (Electronic)
IS  - 0898-9621 (Linking)
VI  - 18
IP  - 6
DP  - 2011 Nov
TI  - Disclosure of individualized research results: a precautionary approach.
PG  - 382-97
LID - 10.1080/08989621.2011.622172 [doi]
AB  - Assessing and managing risks to participants is a central point of contention in 
      the debate about disclosing individualized research results. Those who favor
      disclosure of only clinically significant results think that disclosing
      clinically insignificant results is risky and costly, and that harm prevention
      should take precedence over other ethical considerations. Those who favor giving 
      participants the option of full disclosure regard these risks as insubstantial,
      and think that obligations to benefit participants and promote their autonomy and
      right to know outweigh the obligation to prevent harm or financial
      considerations. The risks of disclosing clinically insignificant research results
      are currently not quantifiable, due to lack of empirical data. The precautionary 
      principle provides some insight into this debate because it applies to
      decision-making concerning risks that are plausible but not quantifiable. A
      precautionary approach would favor full disclosure of individualized results with
      appropriate safeguards to prevent, minimize, or mitigate risks to participants,
      such as: validating testing methods; informing participants about their options
      for receiving tests results and the potential benefits and risks related to
      receiving results; assessing participants' comfort with handling uncertainty;
      providing counseling and advice to participants; following-up with individuals
      who receive tests results; and forming community advisory boards to help
      investigators deal with issues related to disclosure.
FAU - Resnik, David B
AU  - Resnik DB
AD  - National Institute for Environmental Health Sciences, National Institutes of
      Health, Research Triangle Park, North Carolina, USA. resnikd@niehs.nih.gov
LA  - eng
GR  - ZIA ES102646-03/Intramural NIH HHS/United States
GR  - ZIA ES102646-04/Intramural NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Account Res
JT  - Accountability in research
JID - 9100813
SB  - IM
MH  - Beneficence
MH  - Confidentiality/ethics
MH  - Decision Making/*ethics
MH  - *Ethics, Research
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Judgment/*ethics
MH  - *Patient Participation
MH  - Risk
MH  - Truth Disclosure/*ethics
PMC - PMC3953618
MID - NIHMS561126
EDAT- 2011/10/21 06:00
MHDA- 2012/02/24 06:00
CRDT- 2011/10/21 06:00
PHST- 2011/10/21 06:00 [entrez]
PHST- 2011/10/21 06:00 [pubmed]
PHST- 2012/02/24 06:00 [medline]
AID - 10.1080/08989621.2011.622172 [doi]
PST - ppublish
SO  - Account Res. 2011 Nov;18(6):382-97. doi: 10.1080/08989621.2011.622172.


PMID- 22011067
OWN - NLM
STAT- MEDLINE
DCOM- 20120223
LR  - 20111020
IS  - 1545-5815 (Electronic)
IS  - 0898-9621 (Linking)
VI  - 18
IP  - 6
DP  - 2011 Nov
TI  - The limits of sharing: an ethical analysis of the arguments for and against the
      sharing of databases and material banks.
PG  - 357-81
LID - 10.1080/08989621.2011.609443 [doi]
AB  - In this article, I study the challenges that make database and material bank
      sharing difficult for many researchers. I assert that if sharing is prima facie
      ethical (a view that I will defend), then any practices that limit sharing
      require justification. I argue that: 1) data and material sharing is ethical for 
      many stakeholders; 2) there are, however, certain reasonable limits to sharing;
      and 3) the rationale and validity of arguments for any limitations to sharing
      must be made transparent. I conclude by providing general recommendations for how
      to ethically share databases and material banks.
FAU - Smith, Elise
AU  - Smith E
AD  - Bioethics Programs, Department of Social and Preventive Medicine, School of
      Public Health, Universite de Montreal, Montreal, Canada. elise.smith@umontreal.ca
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Account Res
JT  - Accountability in research
JID - 9100813
SB  - IM
MH  - Biomedical Research/ethics
MH  - Cooperative Behavior
MH  - *Diffusion of Innovation
MH  - *Ethics, Research
MH  - Humans
MH  - Information Dissemination/*ethics/methods
MH  - Informed Consent
MH  - International Cooperation
MH  - Interprofessional Relations/*ethics
EDAT- 2011/10/21 06:00
MHDA- 2012/02/24 06:00
CRDT- 2011/10/21 06:00
PHST- 2011/10/21 06:00 [entrez]
PHST- 2011/10/21 06:00 [pubmed]
PHST- 2012/02/24 06:00 [medline]
AID - 10.1080/08989621.2011.609443 [doi]
PST - ppublish
SO  - Account Res. 2011 Nov;18(6):357-81. doi: 10.1080/08989621.2011.609443.


PMID- 22010601
OWN - NLM
STAT- MEDLINE
DCOM- 20111229
LR  - 20191112
IS  - 1932-149X (Print)
IS  - 1932-149X (Linking)
VI  - 6
IP  - 4
DP  - 2011 Jul-Aug
TI  - Planning for the next influenza pandemic: using the science and art of logistics.
PG  - 243-54
AB  - The complexities and challenges for healthcare providers and their efforts to
      provide fundamental basic items to meet the logistical demands of an influenza
      pandemic are discussed in this article. The supply chain, planning, and
      alternatives for inevitable shortages are some of the considerations associated
      with this emergency mass critical care situation. The planning process and
      support for such events are discussed in detail with several recommendations
      obtained from the literature and the experience from recent mass casualty
      incidents (MCIs). The first step in this planning process is the development of
      specific triage requirements during an influenza pandemic. The second step is
      identification of logistical resources required during such a pandemic, which are
      then analyzed within the proposed logistics science and art model for planning
      purposes. Resources highlighted within the model include allocation and use of
      work force, bed space, intensive care unit assets, ventilators, personal
      protective equipment, and oxygen. The third step is using the model to discuss in
      detail possible workarounds, suitable substitutes, and resource allocation. An
      examination is also made of the ethics surrounding palliative care within the
      construction of an MCI and the factors that will inevitably determine rationing
      and prioritizing of these critical assets to palliative care patients.
FAU - Cupp, O Shawn
AU  - Cupp OS
AD  - Department of Logistics and Resource Operations, US Army Command and General at
      Staff College, Fort Leavenworth, Kansas, USA.
FAU - Predmore, Brad G
AU  - Predmore BG
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Disaster Med
JT  - American journal of disaster medicine
JID - 101291100
SB  - IM
MH  - Critical Care/organization & administration
MH  - Disaster Planning/*organization & administration
MH  - Health Planning/*organization & administration
MH  - Humans
MH  - Influenza, Human/epidemiology/*prevention & control
MH  - Mass Casualty Incidents/*prevention & control
MH  - *Pandemics
MH  - Triage/organization & administration
EDAT- 2011/10/21 06:00
MHDA- 2011/12/30 06:00
CRDT- 2011/10/21 06:00
PHST- 2011/10/21 06:00 [entrez]
PHST- 2011/10/21 06:00 [pubmed]
PHST- 2011/12/30 06:00 [medline]
AID - 10.5055/ajdm.2011.0063 [doi]
PST - ppublish
SO  - Am J Disaster Med. 2011 Jul-Aug;6(4):243-54. doi: 10.5055/ajdm.2011.0063.


PMID- 22010570
OWN - NLM
STAT- MEDLINE
DCOM- 20111229
LR  - 20190923
IS  - 1547-1896 (Print)
IS  - 0893-7400 (Linking)
VI  - 24
IP  - 10
DP  - 2011 Oct
TI  - The ethics of coding: are we committing fraud?
PG  - 67-8
FAU - Hill, Helene
AU  - Hill H
AD  - Spring Arbor University.
FAU - Hill, Matthew
AU  - Hill M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - JAAPA
JT  - JAAPA : official journal of the American Academy of Physician Assistants
JID - 9513102
MH  - Clinical Coding/economics/*ethics/legislation & jurisprudence
MH  - Fees and Charges/*ethics
MH  - *Fraud
MH  - Humans
MH  - *Physician Assistants
MH  - United States
EDAT- 2011/10/21 06:00
MHDA- 2011/12/30 06:00
CRDT- 2011/10/21 06:00
PHST- 2011/10/21 06:00 [entrez]
PHST- 2011/10/21 06:00 [pubmed]
PHST- 2011/12/30 06:00 [medline]
AID - 10.1097/01720610-201110000-00013 [doi]
PST - ppublish
SO  - JAAPA. 2011 Oct;24(10):67-8. doi: 10.1097/01720610-201110000-00013.


PMID- 22010552
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20161125
IS  - 0954-7762 (Print)
IS  - 0954-7762 (Linking)
VI  - 107
IP  - 37
DP  - 2011 Sep 20-26
TI  - The NMC code: conduct, performance and ethics.
PG  - 12-4
AB  - The Code: Standards of Conduct, Performance and Ethics for Nurses and Midwives is
      a set of key principles that should underpin the practice of all nurses and
      midwives, and remind them of their professional responsibilities. It is not just 
      a tool used in fitness-to-practise cases--it should be used to guide daily
      practice for all nurses and midwives. Alongside other standards, guidance and
      advice from the NMC, the code should be used to support professional development.
FAU - Goldsmith, Jan
AU  - Goldsmith J
AD  - Nursing and Midwifery Council.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Times
JT  - Nursing times
JID - 0423236
MH  - *Codes of Ethics
MH  - *Ethics, Nursing
MH  - Humans
MH  - Midwifery/*ethics
MH  - Nursing Staff/*ethics
MH  - United Kingdom
EDAT- 2011/10/21 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/10/21 06:00
PHST- 2011/10/21 06:00 [entrez]
PHST- 2011/10/21 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
PST - ppublish
SO  - Nurs Times. 2011 Sep 20-26;107(37):12-4.


PMID- 22010425
OWN - NLM
STAT- MEDLINE
DCOM- 20120325
LR  - 20111020
IS  - 0033-2240 (Print)
IS  - 0033-2240 (Linking)
VI  - 68
IP  - 8
DP  - 2011
TI  - [The challenges of the ethics of personalism to clinical toxicology].
PG  - 405-9
AB  - The fields of philosophical anthropology and the ethics of personalism overlap in
      the area of many difficult personal situations involving clinical toxicology.
      These therapeutic situations need an integral, multidimensional, and personal
      approach for both the patient and the toxicologist. This means that man is
      treated not only as a physical (biological) being but also there is an
      appreciation for the mental sphere, which includes rational, emotional, and
      spiritual elements while not forgetting that the human person is also part of the
      human community. Studying such an individual's personal decision as suicide, we
      must realize that it's not just physiological or biochemical poisons but also
      includes the poisoning of the psyche, as well as poisoning relationships with
      loved ones (family), poisoning social relations (in school or the workplace) and 
      poisoning the spirit, in other words, there is no meaning in life itself, nor the
      meaning of God's existence, nor the meaning of faith, hope and love. Not only is 
      there a greater "variety of poisons" than before, they are much more extensive
      and deep. For example, we can name environmental pollution, industrial poisons,
      chemical waste, genetic modification, powerful medications, or even the toxic
      social environment of evil ideas, malicious manipulation of the human mind
      (destructive religious sects). In approaching the challenges of clinical
      toxicology, the doctor must not only be a specialist in chemistry, biochemistry
      and pharmacology. What then is of future of toxicology because of this human
      dimension (anthropological, ethical and spiritual) of this teaching? As today
      marks the occasion of the 45th anniversary of the Clinic of Toxicology CM UJ,
      should we shape the ethos of young doctors who want to deal with toxicology
      seriously?
FAU - Brusilo, Jerzy
AU  - Brusilo J
LA  - pol
PT  - Editorial
PT  - English Abstract
TT  - Etyka personalistyczna wobec wyzwan toksykologii klinicznej.
PL  - Poland
TA  - Przegl Lek
JT  - Przeglad lekarski
JID - 19840720R
SB  - IM
MH  - Humans
MH  - Personal Health Services/*ethics
MH  - Poisoning/ethnology
MH  - Suicide/ethnology
MH  - Toxicology/*ethics/*trends
EDAT- 2011/10/21 06:00
MHDA- 2012/03/27 06:00
CRDT- 2011/10/21 06:00
PHST- 2011/10/21 06:00 [entrez]
PHST- 2011/10/21 06:00 [pubmed]
PHST- 2012/03/27 06:00 [medline]
PST - ppublish
SO  - Przegl Lek. 2011;68(8):405-9.


PMID- 22009720
OWN - NLM
STAT- MEDLINE
DCOM- 20120221
LR  - 20180802
IS  - 1424-3997 (Electronic)
IS  - 0036-7672 (Linking)
VI  - 141
DP  - 2011
TI  - Perinatal care at the limit of viability between 22 and 26 completed weeks of
      gestation in Switzerland. 2011 revision of the Swiss recommendations.
PG  - w13280
LID - 10.4414/smw.2011.13280 [doi]
LID - 2011;141:w13280 [pii]
AB  - Perinatal care of pregnant women at high risk for preterm delivery and of preterm
      infants born at the limit of viability (22-26 completed weeks of gestation)
      requires a multidisciplinary approach by an experienced perinatal team. Limited
      precision in the determination of both gestational age and foetal weight, as well
      as biological variability may significantly affect the course of action chosen in
      individual cases. The decisions that must be taken with the pregnant women and on
      behalf of the preterm infant in this context are complex and have far-reaching
      consequences. When counselling pregnant women and their partners, neonatologists 
      and obstetricians should provide them with comprehensive information in a
      sensitive and supportive way to build a basis of trust. The decisions are
      developed in a continuing dialogue between all parties involved (physicians,
      midwives, nursing staff and parents) with the principal aim to find solutions
      that are in the infant's and pregnant woman's best interest. Knowledge of current
      gestational age-specific mortality and morbidity rates and how they are modified 
      by prenatally known prognostic factors (estimated foetal weight, sex, exposure or
      nonexposure to antenatal corticosteroids, single or multiple births) as well as
      the application of accepted ethical principles form the basis for responsible
      decision-making. Communication between all parties involved plays a central role.
      The members of the interdisciplinary working group suggest that the care of
      preterm infants with a gestational age between 22 0/7 and 23 6/7 weeks should
      generally be limited to palliative care. Obstetric interventions for foetal
      indications such as Caesarean section delivery are usually not indicated. In
      selected cases, for example, after 23 weeks of pregnancy have been completed and 
      several of the above mentioned prenatally known prognostic factors are favourable
      or well informed parents insist on the initiation of life-sustaining therapies,
      active obstetric interventions for foetal indications and provisional intensive
      care of the neonate may be reasonable. In preterm infants with a gestational age 
      between 24 0/7 and 24 6/7 weeks, it can be difficult to determine whether the
      burden of obstetric interventions and neonatal intensive care is justified given 
      the limited chances of success of such a therapy. In such cases, the individual
      constellation of prenatally known factors which impact on prognosis can be
      helpful in the decision making process with the parents. In preterm infants with 
      a gestational age between 25 0/7 and 25 6/7 weeks, foetal surveillance, obstetric
      interventions for foetal indications and neonatal intensive care measures are
      generally indicated. However, if several prenatally known prognostic factors are 
      unfavourable and the parents agree, primary non-intervention and neonatal
      palliative care can be considered. All pregnant women with threatening preterm
      delivery or premature rupture of membranes at the limit of viability must be
      transferred to a perinatal centre with a level III neonatal intensive care unit
      no later than 23 0/7 weeks of gestation, unless emergency delivery is indicated. 
      An experienced neonatology team should be involved in all deliveries that take
      place after 23 0/7 weeks of gestation to help to decide together with the parents
      if the initiation of intensive care measures appears to be appropriate or if
      preference should be given to palliative care (i.e., primary non-intervention).
      In doubtful situations, it can be reasonable to initiate intensive care and to
      admit the preterm infant to a neonatal intensive care unit (i.e., provisional
      intensive care). The infant's clinical evolution and additional discussions with 
      the parents will help to clarify whether the life-sustaining therapies should be 
      continued or withdrawn. Life support is continued as long as there is reasonable 
      hope for survival and the infant's burden of intensive care is acceptable. If, on
      the other hand, the health care team and the parents have to recognise that in
      the light of a very poor prognosis the burden of the currently used therapies has
      become disproportionate, intensive care measures are no longer justified and
      other aspects of care (e.g., relief of pain and suffering) are the new priorities
      (i.e., redirection of care). If a decision is made to withhold or withdraw
      life-sustaining therapies, the health care team should focus on comfort care for 
      the dying infant and support for the parents.
FAU - Berger, Thomas M
AU  - Berger TM
AD  - Neonatal and Paediatric Intensive Care Unit, Children's Hospital of Lucerne,
      Switzerland. thomas.berger@luks.ch
FAU - Bernet, Vera
AU  - Bernet V
FAU - El Alama, Susanna
AU  - El Alama S
FAU - Fauchere, Jean-Claude
AU  - Fauchere JC
FAU - Hosli, Irene
AU  - Hosli I
FAU - Irion, Olivier
AU  - Irion O
FAU - Kind, Christian
AU  - Kind C
FAU - Latal, Bea
AU  - Latal B
FAU - Nelle, Mathias
AU  - Nelle M
FAU - Pfister, Riccardo E
AU  - Pfister RE
FAU - Surbek, Daniel
AU  - Surbek D
FAU - Truttmann, Anita C
AU  - Truttmann AC
FAU - Wisser, Joseph
AU  - Wisser J
FAU - Zimmermann, Roland
AU  - Zimmermann R
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111018
PL  - Switzerland
TA  - Swiss Med Wkly
JT  - Swiss medical weekly
JID - 100970884
RN  - 0 (Adrenal Cortex Hormones)
SB  - IM
MH  - Adrenal Cortex Hormones
MH  - Delivery, Obstetric
MH  - Female
MH  - Fetal Development/drug effects
MH  - *Gestational Age
MH  - *Guidelines as Topic
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Male
MH  - Palliative Care
MH  - *Perinatal Care/ethics
MH  - Pregnancy
MH  - *Premature Birth
MH  - Quality Assurance, Health Care
MH  - Resuscitation Orders
MH  - Switzerland
EDAT- 2011/10/20 06:00
MHDA- 2012/02/22 06:00
CRDT- 2011/10/20 06:00
PHST- 2011/10/20 06:00 [entrez]
PHST- 2011/10/20 06:00 [pubmed]
PHST- 2012/02/22 06:00 [medline]
AID - smw-13280 [pii]
AID - 10.4414/smw.2011.13280 [doi]
PST - epublish
SO  - Swiss Med Wkly. 2011 Oct 18;141:w13280. doi: 10.4414/smw.2011.13280. eCollection 
      2011.


PMID- 22009266
OWN - NLM
STAT- MEDLINE
DCOM- 20130604
LR  - 20211020
IS  - 1573-2789 (Electronic)
IS  - 0010-3853 (Linking)
VI  - 49
IP  - 1
DP  - 2013 Feb
TI  - Consumer and practitioner perceptions of the harm reduction approach in a
      community mental health setting.
PG  - 14-24
LID - 10.1007/s10597-011-9451-4 [doi]
AB  - Harm reduction in community mental health settings can be effective in engaging
      persons with co-occurring disorders in services. In this qualitative study,
      personal interviews and grounded theory methods were used to explore the
      experiences of 21 mental health practitioners and 15 consumers with co-occurring 
      disorders at a community mental health housing program that uses harm reduction. 
      Results indicate that while harm reduction enhanced therapeutic alliances,
      ethical and emotional tensions between practitioners and consumers regarding
      their views on self-determination and tolerance of drug-related behaviors were
      also evident. These tensions are explored and implications for practice and
      education are provided.
FAU - Mancini, Michael A
AU  - Mancini MA
AD  - School of Social Work, Saint Louis University, Saint Louis, MO 63103, USA.
      mancinim@slu.edu
FAU - Wyrick-Waugh, Wynter
AU  - Wyrick-Waugh W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111019
PL  - United States
TA  - Community Ment Health J
JT  - Community mental health journal
JID - 0005735
SB  - IM
MH  - Adult
MH  - Community Mental Health Services/*organization & administration
MH  - Community Participation
MH  - Comorbidity
MH  - Diagnosis, Dual (Psychiatry)
MH  - Female
MH  - *Harm Reduction
MH  - Homeless Persons
MH  - *Housing
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Mental Disorders/epidemiology/psychology/*rehabilitation
MH  - Middle Aged
MH  - *Perception
MH  - Process Assessment, Health Care
MH  - Professional-Patient Relations
MH  - Qualitative Research
MH  - Substance-Related Disorders/epidemiology/psychology/*rehabilitation
EDAT- 2011/10/20 06:00
MHDA- 2013/06/05 06:00
CRDT- 2011/10/20 06:00
PHST- 2011/01/31 00:00 [received]
PHST- 2011/10/06 00:00 [accepted]
PHST- 2011/10/20 06:00 [entrez]
PHST- 2011/10/20 06:00 [pubmed]
PHST- 2013/06/05 06:00 [medline]
AID - 10.1007/s10597-011-9451-4 [doi]
PST - ppublish
SO  - Community Ment Health J. 2013 Feb;49(1):14-24. doi: 10.1007/s10597-011-9451-4.
      Epub 2011 Oct 19.


PMID- 22009258
OWN - NLM
STAT- MEDLINE
DCOM- 20120424
LR  - 20211020
IS  - 1433-0563 (Electronic)
IS  - 0340-2592 (Linking)
VI  - 50
IP  - 12
DP  - 2011 Dec
TI  - [Cancer screening: curative or harmful? An ethical dilemma facing the physician].
PG  - 1595-9
LID - 10.1007/s00120-011-2727-z [doi]
AB  - Early detection based on prostate-specific antigen (PSA) presumably can reduce
      prostate cancer mortality. At the same time it is associated with a comparatively
      high rate of overdiagnosis involving tumors that would not have become apparent
      without screening since they would have remained asymptomatic during the
      patient's entire life. Current studies show that the probability of such an
      overdiagnosis is 12-48 times higher than one which would save a man's life. Thus,
      overdiagnosis poses an ethical dilemma for physicians: their actions (screening
      examination) can turn a healthy individual into a chronically ill person. This
      profoundly contradicts the principle of medical ethics to"do no harm." An open
      debate on whether early detection can be reconciled with doctors' ethical duties 
      is hampered by the implications of liability law, faulty economic incentives, and
      the pressures of competition as well as the empirical practice of many physicians
      to overestimate the benefits of cancer screening.
FAU - Schaefer, C
AU  - Schaefer C
AD  - Stiftung Mannergesundheit, Reinhardtstrasse 2, 10117 Berlin, Deutschland.
FAU - Weissbach, L
AU  - Weissbach L
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Fruherkennung: heilen oder krank machen? : Der Arzt im ethischen Zwiespalt.
PL  - Germany
TA  - Urologe A
JT  - Der Urologe. Ausg. A
JID - 1304110
RN  - EC 3.4.21.77 (Prostate-Specific Antigen)
SB  - IM
MH  - Germany/epidemiology
MH  - Health Services Misuse/*trends
MH  - Humans
MH  - Male
MH  - Mass Screening/*ethics
MH  - Medical Oncology/*ethics
MH  - Physicians/*ethics
MH  - Prostate-Specific Antigen/*blood
MH  - Prostatic Neoplasms/*blood/*diagnosis
EDAT- 2011/10/20 06:00
MHDA- 2012/04/25 06:00
CRDT- 2011/10/20 06:00
PHST- 2011/10/20 06:00 [entrez]
PHST- 2011/10/20 06:00 [pubmed]
PHST- 2012/04/25 06:00 [medline]
AID - 10.1007/s00120-011-2727-z [doi]
PST - ppublish
SO  - Urologe A. 2011 Dec;50(12):1595-9. doi: 10.1007/s00120-011-2727-z.


PMID- 22008952
OWN - NLM
STAT- MEDLINE
DCOM- 20120216
LR  - 20111031
IS  - 1432-0738 (Electronic)
IS  - 0340-5761 (Linking)
VI  - 85
IP  - 11
DP  - 2011 Nov
TI  - Developmental toxicity testing in the 21st century: the sword of Damocles
      shattered by embryonic stem cell assays?
PG  - 1361-72
LID - 10.1007/s00204-011-0767-1 [doi]
AB  - Modern society faces an inherent dilemma. In our globalized society, we are
      spoilt for choice by an ever-increasing number of products, many of which are
      made of new materials and compound mixtures. At the same time, as consumers we
      got accustomed to the idea of a life minimized for risk, including our own
      exposure to chemicals from the environment or to compounds present in and
      released from everyday products. Chemical safety testing bridges these obviously 
      diverging interests, and the corresponding legislation has hence been
      tremendously extended (e.g., introduction of the European legislation REACH in
      2007). However, the underlying regulatory toxicology still relies mainly on
      animal testing, which is relatively slow, expensive, and ethically arguable.
      Meanwhile, recent years have seen a surge in efforts to develop alternative
      testing systems and strategies. Expectations are particularly high for the
      applicability of stem cells as test systems especially for developmental toxicity
      testing in vitro. For the first time in history, test systems can be based on
      differentiating cells and tissue progenitors in culture, thus bringing the
      'vision of toxicity testing in the 21st century' a step closer.
FAU - Seiler, Andrea
AU  - Seiler A
AD  - Department of Experimental Toxicology and Center for Alternatives to Animal
      Testing, German Federal Institute for Risk Assessment (BfR), Thielallee 88-92,
      Berlin, Germany.
FAU - Oelgeschlager, Michael
AU  - Oelgeschlager M
FAU - Liebsch, Manfred
AU  - Liebsch M
FAU - Pirow, Ralph
AU  - Pirow R
FAU - Riebeling, Christian
AU  - Riebeling C
FAU - Tralau, Tewes
AU  - Tralau T
FAU - Luch, Andreas
AU  - Luch A
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111019
PL  - Germany
TA  - Arch Toxicol
JT  - Archives of toxicology
JID - 0417615
SB  - IM
MH  - Animal Testing Alternatives/*methods
MH  - Animals
MH  - Embryonic Stem Cells/drug effects
MH  - Humans
MH  - Myocytes, Cardiac/cytology/metabolism
MH  - Risk Assessment
MH  - Toxicity Tests/*methods/*trends
MH  - Toxicology/*trends
EDAT- 2011/10/20 06:00
MHDA- 2012/02/18 06:00
CRDT- 2011/10/20 06:00
PHST- 2011/09/29 00:00 [received]
PHST- 2011/10/06 00:00 [accepted]
PHST- 2011/10/20 06:00 [entrez]
PHST- 2011/10/20 06:00 [pubmed]
PHST- 2012/02/18 06:00 [medline]
AID - 10.1007/s00204-011-0767-1 [doi]
PST - ppublish
SO  - Arch Toxicol. 2011 Nov;85(11):1361-72. doi: 10.1007/s00204-011-0767-1. Epub 2011 
      Oct 19.


PMID- 22008649
OWN - NLM
STAT- MEDLINE
DCOM- 20120326
LR  - 20211020
IS  - 1471-2458 (Electronic)
IS  - 1471-2458 (Linking)
VI  - 11
DP  - 2011 Oct 18
TI  - The case for conducting first-in-human (phase 0 and phase 1) clinical trials in
      low and middle income countries.
PG  - 811
LID - 10.1186/1471-2458-11-811 [doi]
AB  - BACKGROUND: Despite the increase in the number of clinical trials in low and
      middle income countries (LMICs), there has been little serious discussion of
      whether First in Human (FIH; phase 0 and phase 1) clinical trials should be
      conducted in LMICs, and if so, under what conditions. Based on our own
      experience, studies and consultations, this paper aims to stimulate debate on our
      contention that for products meant primarily for conditions most prevalent in
      LMICs, FIH trials should preferably be done first in those countries. DISCUSSION:
      There are scientific and pragmatic arguments that support conducting FIH trials
      in LMIC. Furthermore, the changing product-development and regulatory landscape, 
      and the likelihood of secondary benefits such as capacity building for innovation
      and for research ethics support our argument. These arguments take into account
      the critical importance of protecting human subjects of research while developing
      capacity to undertake FIH trials. SUMMARY: While FIH trials have historically not
      been conducted in LMICs, the situation in some of these countries has changed.
      Hence, we have argued that FIH should be conducted in LMICs for products meant
      primarily for conditions that are most prevalent in those contexts; provided the 
      necessary protections for human subjects are sufficient.
FAU - Kapiriri, Lydia
AU  - Kapiriri L
AD  - Department of Health Aging and Society, McMaster University, Hamilton, Ontario,
      L8S 4M4, Canada.
FAU - Lavery, James V
AU  - Lavery JV
FAU - Singer, Peter A
AU  - Singer PA
FAU - Mshinda, Hassan
AU  - Mshinda H
FAU - Babiuk, Lorne
AU  - Babiuk L
FAU - Daar, Abdallah S
AU  - Daar AS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111018
PL  - England
TA  - BMC Public Health
JT  - BMC public health
JID - 100968562
SB  - IM
MH  - Clinical Trials, Phase I as Topic/*statistics & numerical data
MH  - *Developing Countries
MH  - Humans
PMC - PMC3339411
EDAT- 2011/10/20 06:00
MHDA- 2012/03/27 06:00
CRDT- 2011/10/20 06:00
PHST- 2011/02/17 00:00 [received]
PHST- 2011/10/18 00:00 [accepted]
PHST- 2011/10/20 06:00 [entrez]
PHST- 2011/10/20 06:00 [pubmed]
PHST- 2012/03/27 06:00 [medline]
AID - 1471-2458-11-811 [pii]
AID - 10.1186/1471-2458-11-811 [doi]
PST - epublish
SO  - BMC Public Health. 2011 Oct 18;11:811. doi: 10.1186/1471-2458-11-811.


PMID- 22008552
OWN - NLM
STAT- MEDLINE
DCOM- 20120626
LR  - 20220311
IS  - 1600-6143 (Electronic)
IS  - 1600-6135 (Linking)
VI  - 12
IP  - 2
DP  - 2012 Feb
TI  - Micro RNA expression profiles as adjunctive data to assess the risk of
      hepatocellular carcinoma recurrence after liver transplantation.
PG  - 428-37
LID - 10.1111/j.1600-6143.2011.03788.x [doi]
AB  - Donor livers are precious resources and it is, therefore, ethically imperative
      that we employ optimally sensitive and specific transplant selection criteria.
      Current selection criteria, the Milan criteria, for liver transplant candidates
      with hepatocellular carcinoma (HCC) are primarily based on radiographic
      characteristics of the tumor. Although the Milan criteria result in reasonably
      high survival and low-recurrence rates, they do not assess an individual
      patient's tumor biology and recurrence risk. Consequently, it is difficult to
      predict on an individual basis the risk for recurrent disease. To address this,
      we employed microarray profiling of microRNA (miRNA) expression from formalin
      fixed paraffin embedded tissues to define a biomarker that distinguishes between 
      patients with and without HCC recurrence after liver transplant. In our cohort of
      64 patients, this biomarker outperforms the Milan criteria in that it identifies 
      patients outside of Milan who did not have recurrent disease and patients within 
      Milan who had recurrence. We also describe a method to account for multifocal
      tumors in biomarker signature discovery.
CI  - (c) 2011 The American Society of Transplantation and the American Society of
      Transplant Surgeons.
FAU - Barry, C T
AU  - Barry CT
AD  - Department of Surgery, University of Rochester Medical Center, Rochester, NY,
      USA. chris_barry@urmc.rochester.edu
FAU - D'Souza, M
AU  - D'Souza M
FAU - McCall, M
AU  - McCall M
FAU - Safadjou, S
AU  - Safadjou S
FAU - Ryan, C
AU  - Ryan C
FAU - Kashyap, R
AU  - Kashyap R
FAU - Marroquin, C
AU  - Marroquin C
FAU - Orloff, M
AU  - Orloff M
FAU - Almudevar, A
AU  - Almudevar A
FAU - Godfrey, T E
AU  - Godfrey TE
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20111018
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Neoplasm)
SB  - IM
MH  - Biomarkers, Tumor/biosynthesis/genetics
MH  - Biopsy
MH  - Carcinoma, Hepatocellular/*genetics/pathology/surgery
MH  - Female
MH  - Follow-Up Studies
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Liver Neoplasms/*genetics/pathology/surgery
MH  - *Liver Transplantation
MH  - Male
MH  - MicroRNAs/biosynthesis/*genetics
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/*genetics/pathology
MH  - Prognosis
MH  - RNA, Neoplasm/*genetics
MH  - Retrospective Studies
EDAT- 2011/10/20 06:00
MHDA- 2012/06/27 06:00
CRDT- 2011/10/20 06:00
PHST- 2011/10/20 06:00 [entrez]
PHST- 2011/10/20 06:00 [pubmed]
PHST- 2012/06/27 06:00 [medline]
AID - 10.1111/j.1600-6143.2011.03788.x [doi]
PST - ppublish
SO  - Am J Transplant. 2012 Feb;12(2):428-37. doi: 10.1111/j.1600-6143.2011.03788.x.
      Epub 2011 Oct 18.


PMID- 22008502
OWN - NLM
STAT- MEDLINE
DCOM- 20120216
LR  - 20211020
IS  - 1542-474X (Electronic)
IS  - 1082-720X (Linking)
VI  - 16
IP  - 4
DP  - 2011 Oct
TI  - A statement on ethics from the HEART group.
PG  - 418-20
LID - 10.1111/j.1542-474X.2011.00472.x [doi]
CN  - HEART Group
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Noninvasive Electrocardiol
JT  - Annals of noninvasive electrocardiology : the official journal of the
      International Society for Holter and Noninvasive Electrocardiology, Inc
JID - 9607443
SB  - IM
MH  - Authorship/standards
MH  - Cardiology/standards
MH  - Conflict of Interest
MH  - *Editorial Policies
MH  - *Ethics, Research
MH  - Guidelines as Topic
MH  - Humans
MH  - Publishing/ethics
PMC - PMC6932575
IR  - Ector H
FIR - Ector, Hugo
IR  - Lancelloti P
FIR - Lancelloti, Patrizio
IR  - Roberts WC
FIR - Roberts, William C
IR  - Wenger NK
FIR - Wenger, Nanette K
IR  - Moss AJ
FIR - Moss, Arthur J
IR  - Smith ER
FIR - Smith, Eldon R
IR  - Borer JS
FIR - Borer, Jeffrey S
IR  - Eagle KA
FIR - Eagle, Kim A
IR  - Freedman J
FIR - Freedman, Jane
IR  - Krum H
FIR - Krum, Henry
IR  - Lang C
FIR - Lang, Chim
IR  - Remme WJ
FIR - Remme, Willem J
IR  - Piper HM
FIR - Piper, Hans Michael
IR  - White CJ
FIR - White, Christopher J
IR  - Loscalzo J
FIR - Loscalzo, Joseph
IR  - Marban E
FIR - Marban, Eduardo
IR  - Sobel BE
FIR - Sobel, Burton E
IR  - Roberts R
FIR - Roberts, Robert
IR  - Rahimtoola SH
FIR - Rahimtoola, Shahbudin H
IR  - Camm AJ
FIR - Camm, A John
IR  - Van de Werf F
FIR - Van de Werf, Frans
IR  - Swedberg K
FIR - Swedberg, Karl
IR  - Timmis AD
FIR - Timmis, Adam D
IR  - Stone KS
FIR - Stone, Kathleen S
IR  - Zipes DP
FIR - Zipes, Douglas P
IR  - Iosseliani DG
FIR - Iosseliani, David G
IR  - Taylor AJ
FIR - Taylor, Allen J
IR  - Rosen MR
FIR - Rosen, Michael R
IR  - Grines CL
FIR - Grines, Cindy L
IR  - DeMaria AN
FIR - DeMaria, Anthony N
IR  - Narula J
FIR - Narula, Jagat
IR  - King SB 3rd
FIR - King, Spencer B 3rd
IR  - Wagner GS
FIR - Wagner, Galen S
IR  - Saksena S
FIR - Saksena, Sanjeev
IR  - Pearlman AS
FIR - Pearlman, Alan S
IR  - Bodnar E
FIR - Bodnar, Endre
IR  - Emery RW
FIR - Emery, Robert W
IR  - Cohn LH
FIR - Cohn, Lawrence H
IR  - van der Wall EE
FIR - van der Wall, Ernst E
IR  - Abdulla RI
FIR - Abdulla, Ra-id
IR  - Lesch M
FIR - Lesch, Michael
IR  - Alfonso F
FIR - Alfonso, Fernando
IR  - Ekroth R
FIR - Ekroth, Rolf
EDAT- 2011/10/20 06:00
MHDA- 2012/02/18 06:00
CRDT- 2011/10/20 06:00
PHST- 2011/10/20 06:00 [entrez]
PHST- 2011/10/20 06:00 [pubmed]
PHST- 2012/02/18 06:00 [medline]
AID - 10.1111/j.1542-474X.2011.00472.x [doi]
PST - ppublish
SO  - Ann Noninvasive Electrocardiol. 2011 Oct;16(4):418-20. doi:
      10.1111/j.1542-474X.2011.00472.x.


PMID- 22008453
OWN - NLM
STAT- MEDLINE
DCOM- 20160422
LR  - 20181201
IS  - 1945-1938 (Electronic)
IS  - 1049-023X (Linking)
VI  - 26
IP  - 4
DP  - 2011 Aug
TI  - Hospital disaster planning in the Western cape, South Africa.
PG  - 283-8
LID - 10.1017/S1049023X11006571 [doi]
AB  - INTRODUCTION: The aim of this study was to describe the current state of disaster
      preparedness in hospitals in the public sector in the Western Cape, South Africa 
      with the advent of the FIFA 2010 Soccer World Cup. The objectives included the
      completion of a self-reported assessment of readiness at all Western Cape public 
      sector hospitals, to identify best practice and shortfalls in these facilities,
      as well as putting forward recommendations for improving disaster preparedness at
      these hospitals. METHODS: The National Department of Health, as part of the
      planning for the FIFA 2010 World Cup, appointed an expert committee to coordinate
      improvements in disaster medicine throughout the country. This workgroup
      developed a Self Reported Hospital Assessment Questionnaire, which was sent to
      all hospitals across the country. Data only were collected from public hospitals 
      in the Western Cape and entered onto a purpose-built database. Basic descriptive 
      statistics were calculated. Ethical approval was obtained from the Health
      Sciences Faculty Research Committee of the University of Cape Town. RESULTS:
      Twenty-seven of the 41 (68%) public hospitals provided completed data on disaster
      planning. The study was able to ascertain what infrastructure is available and
      what planning already has been implemented at these institutions.
      RECOMMENDATIONS: Most hospitals in the Western Cape have a disaster plan for
      their facility. Certain areas need more focus and attention; these include: (1)
      increasing collaborative partnerships; (2) improving HAZMAT response resources;
      (3) specific plans for vulnerable populations; (4) contingency plans for
      communication failure; (5) visitor, media and VIP dedicated areas and personnel; 
      (6) evacuation and surge capacity plans; and (7) increased attention to training 
      and disaster plan exercises.
FAU - Stander, Melanie
AU  - Stander M
AD  - Division of Emergency Medicine, Stellenbosch University, Cape Town, South Africa.
FAU - Wallis, Lee Alan
AU  - Wallis LA
FAU - Smith, Wayne Patrick
AU  - Smith WP
LA  - eng
PT  - Journal Article
DEP - 20111007
PL  - United States
TA  - Prehosp Disaster Med
JT  - Prehospital and disaster medicine
JID - 8918173
MH  - *Disaster Planning
MH  - Disasters
MH  - Hospital Planning
MH  - Humans
MH  - South Africa
MH  - *Surge Capacity
EDAT- 2011/10/20 06:00
MHDA- 2016/04/23 06:00
CRDT- 2011/10/20 06:00
PHST- 2011/10/20 06:00 [entrez]
PHST- 2011/10/20 06:00 [pubmed]
PHST- 2016/04/23 06:00 [medline]
AID - S1049023X11006571 [pii]
AID - 10.1017/S1049023X11006571 [doi]
PST - ppublish
SO  - Prehosp Disaster Med. 2011 Aug;26(4):283-8. doi: 10.1017/S1049023X11006571. Epub 
      2011 Oct 7.


PMID- 22008451
OWN - NLM
STAT- MEDLINE
DCOM- 20120430
LR  - 20181201
IS  - 1755-3768 (Electronic)
IS  - 1755-375X (Linking)
VI  - 90
IP  - 1
DP  - 2012 Feb
TI  - Unjustified invasive clinical research raises ethical concerns.
PG  - e77-8; author reply e78-9
LID - 10.1111/j.1755-3768.2011.02279.x [doi]
FAU - Grzybowski, Andrzej
AU  - Grzybowski A
LA  - eng
PT  - Letter
PT  - Comment
DEP - 20111019
PL  - England
TA  - Acta Ophthalmol
JT  - Acta ophthalmologica
JID - 101468102
SB  - IM
CON - Acta Ophthalmol. 2011 Mar;89(2):e142-8. PMID: 21348961
MH  - Cerebrospinal Fluid Pressure/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Ocular Hypertension/*physiopathology
EDAT- 2011/10/20 06:00
MHDA- 2012/05/01 06:00
CRDT- 2011/10/20 06:00
PHST- 2011/10/20 06:00 [entrez]
PHST- 2011/10/20 06:00 [pubmed]
PHST- 2012/05/01 06:00 [medline]
AID - 10.1111/j.1755-3768.2011.02279.x [doi]
PST - ppublish
SO  - Acta Ophthalmol. 2012 Feb;90(1):e77-8; author reply e78-9. doi:
      10.1111/j.1755-3768.2011.02279.x. Epub 2011 Oct 19.


PMID- 22008247
OWN - NLM
STAT- MEDLINE
DCOM- 20120529
LR  - 20211020
IS  - 1559-2030 (Electronic)
IS  - 1551-7144 (Linking)
VI  - 33
IP  - 1
DP  - 2012 Jan
TI  - Anticholinergic versus botulinum toxin A comparison trial for the treatment of
      bothersome urge urinary incontinence: ABC trial.
PG  - 184-96
LID - 10.1016/j.cct.2011.09.019 [doi]
AB  - This trial compares the change in urgency urinary incontinence episodes over 6
      months, tolerability and cost effectiveness between women receiving daily
      anticholinergic therapy plus a single intra-detrusor injection of saline versus a
      single intra-detrusor injection of 100 U of botulinum toxin A plus daily oral
      placebo tablets. We present the rationale and design of a randomized-controlled
      trial, Anticholinergic versus Botulinum Toxin, Comparison Trial for the Treatment
      of Bothersome Urge Urinary Incontinence: ABC trial, conducted by the NICHD-funded
      Pelvic Floor Disorders Network. We discuss the innovative nature of this trial
      and the challenges related to choice of patient population, maintaining masking, 
      cost effectiveness, ethical considerations, measuring adherence, and placebo
      development and testing. Enrollment began in April, 2010. 242 participants will
      be randomized and primary outcome data analysis is anticipated to begin in mid
      2012. Several challenges in the trial design are discussed. Randomization to
      placebo intra-detrusor injections may limit recruitment, potentially impacting
      generalizability. Other challenges included the heavy marketing of drugs for
      overactive bladder which could impact recruitment of drug-naive women. In
      addition, anticholinergic medications often cause dry mouth, making masking
      difficult. Finally, adverse reporting of transient urinary retention is
      challenging as there is no standardized definition; yet this is the most common
      adverse event following intra-detrusor botulinum toxin injection. The ABC trial
      will help women with urgency urinary incontinence balance efficacy, side effects 
      and cost of anticholinergic medication versus botulinum toxin intra-detrusor
      injection. The results have the potential to fundamentally change the therapeutic
      approach to this condition.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Visco, Anthony G
AU  - Visco AG
AD  - Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, 
      North Carolina 27710, USA.
FAU - Brubaker, Linda
AU  - Brubaker L
FAU - Richter, Holly E
AU  - Richter HE
FAU - Nygaard, Ingrid
AU  - Nygaard I
FAU - Paraiso, Marie Fidela
AU  - Paraiso MF
FAU - Menefee, Shawn A
AU  - Menefee SA
FAU - Schaffer, Joseph
AU  - Schaffer J
FAU - Wei, John
AU  - Wei J
FAU - Chai, Toby
AU  - Chai T
FAU - Janz, Nancy
AU  - Janz N
FAU - Spino, Cathie
AU  - Spino C
FAU - Meikle, Susan
AU  - Meikle S
CN  - Pelvic Floor Disorders Network
LA  - eng
SI  - ClinicalTrials.gov/NCT01166438
GR  - U10 HD041261/HD/NICHD NIH HHS/United States
GR  - U01 HD041249/HD/NICHD NIH HHS/United States
GR  - U10 HD054215/HD/NICHD NIH HHS/United States
GR  - 1U10 HD54215/HD/NICHD NIH HHS/United States
GR  - U10 HD041267/HD/NICHD NIH HHS/United States
GR  - 2U10 HD41250/HD/NICHD NIH HHS/United States
GR  - U10 HD041248/HD/NICHD NIH HHS/United States
GR  - 1U10 HD54136/HD/NICHD NIH HHS/United States
GR  - 2U10 HD41267/HD/NICHD NIH HHS/United States
GR  - U10 HD054241/HD/NICHD NIH HHS/United States
GR  - U10 HD041250/HD/NICHD NIH HHS/United States
GR  - U10 HD041267-12/HD/NICHD NIH HHS/United States
GR  - 1U10 HD54241/HD/NICHD NIH HHS/United States
GR  - 2U10 HD41261/HD/NICHD NIH HHS/United States
GR  - 2U01 HD41249/HD/NICHD NIH HHS/United States
GR  - U10 HD054214/HD/NICHD NIH HHS/United States
GR  - 1U10 HD54214/HD/NICHD NIH HHS/United States
GR  - UG1 HD041267/HD/NICHD NIH HHS/United States
GR  - U10 HD054136/HD/NICHD NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
DEP - 20111008
PL  - United States
TA  - Contemp Clin Trials
JT  - Contemporary clinical trials
JID - 101242342
RN  - 0 (Cholinergic Antagonists)
RN  - 0 (Neuromuscular Agents)
RN  - EC 3.4.24.69 (Botulinum Toxins, Type A)
SB  - IM
MH  - Administration, Oral
MH  - Adult
MH  - Botulinum Toxins, Type A/*administration & dosage
MH  - Cholinergic Antagonists/*administration & dosage
MH  - Dose-Response Relationship, Drug
MH  - Double-Blind Method
MH  - Drug Therapy, Combination
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Injections, Intramuscular
MH  - Neuromuscular Agents/administration & dosage
MH  - Retrospective Studies
MH  - Time Factors
MH  - Treatment Outcome
MH  - Urinary Bladder
MH  - Urinary Incontinence, Urge/*drug therapy/physiopathology
MH  - Urodynamics/drug effects
MH  - Young Adult
PMC - PMC3263350
MID - NIHMS337208
IR  - Barber MD
FIR - Barber, Mathew D
IR  - Paraiso MF
FIR - Paraiso, Marie Fidela R
IR  - Walters MD
FIR - Walters, Mark D
IR  - Jelovsek J
FIR - Jelovsek, J Eric
IR  - McElrath L
FIR - McElrath, Linda
IR  - Murphy D
FIR - Murphy, Donel
IR  - Williams C
FIR - Williams, Cheryl
IR  - Visco AG
FIR - Visco, Anthony G
IR  - Amundsen CL
FIR - Amundsen, Cindy L
IR  - Weidner AC
FIR - Weidner, Alison C
IR  - Wu JM
FIR - Wu, Jennifer M
IR  - Raynor MJ
FIR - Raynor, Mary J
IR  - McGuire M
FIR - McGuire, Mary
IR  - Maynor J
FIR - Maynor, Jean
IR  - Brubaker L
FIR - Brubaker, Linda
IR  - Visco AG
FIR - Visco, A G
IR  - Kenton K
FIR - Kenton, Kimberly
IR  - FitzGerald M
FIR - FitzGerald, MaryPat
IR  - Mueller E
FIR - Mueller, Elizabeth
IR  - Tulke M
FIR - Tulke, Mary
IR  - Richter HE
FIR - Richter, Holly E
IR  - Burgio KL
FIR - Burgio, Kathryn L
IR  - Varner R
FIR - Varner, R Edward
IR  - Holley RL
FIR - Holley, Robert L
IR  - Goode PS
FIR - Goode, Patricia S
IR  - Lloyd L
FIR - Lloyd, L Keith
IR  - Wilson T
FIR - Wilson, Tracey
IR  - Markland AD
FIR - Markland, Alayne D
IR  - Willis V
FIR - Willis, Velria
IR  - Saxon N
FIR - Saxon, Nancy
IR  - Ward L
FIR - Ward, LaChele
IR  - Pair LS
FIR - Pair, Lisa S
IR  - Nager CW
FIR - Nager, Charles W
IR  - Menefee SA
FIR - Menefee, Shawn A
IR  - Lukacz E
FIR - Lukacz, Emily
IR  - Luber KM
FIR - Luber, Karl M
IR  - Albo ME
FIR - Albo, Michael E
IR  - Dyer K
FIR - Dyer, Keisha
IR  - Diwadkar G
FIR - Diwadkar, Gouri
IR  - Merrin L
FIR - Merrin, Leah
IR  - Zazueta-Damian G
FIR - Zazueta-Damian, Giselle
IR  - Schaffer J
FIR - Schaffer, Joseph
IR  - Wai C
FIR - Wai, Clifford
IR  - Corton M
FIR - Corton, Marlene
IR  - Rahn D
FIR - Rahn, David
IR  - Lemack G
FIR - Lemack, Gary
IR  - Moore K
FIR - Moore, Kelly
IR  - Atnip S
FIR - Atnip, Shanna
IR  - Hull M
FIR - Hull, Margaret
IR  - Martinez P
FIR - Martinez, Pam
IR  - Lawson D
FIR - Lawson, Deborah
IR  - Nygaard I
FIR - Nygaard, Ingrid
IR  - Norton P
FIR - Norton, Peggy
IR  - Hsu Y
FIR - Hsu, Yvonne
IR  - Freeman L
FIR - Freeman, Linda
IR  - Ranke S
FIR - Ranke, Shirley
IR  - Burr L
FIR - Burr, Laura
IR  - Griffen L
FIR - Griffen, Linda
IR  - Spino C
FIR - Spino, Cathie
IR  - Wei JT
FIR - Wei, John T
IR  - Marchant B
FIR - Marchant, Beverly
IR  - DiFranco D
FIR - DiFranco, Donna
IR  - DeLancey JO
FIR - DeLancey, John O L
IR  - Fenner D
FIR - Fenner, Dee
IR  - Janz NK
FIR - Janz, Nancy K
IR  - Ye W
FIR - Ye, Wen
IR  - Chen Z
FIR - Chen, Zhen
IR  - Casher YW
FIR - Casher, Yang Wang
IR  - Meikle S
FIR - Meikle, Susan
IR  - Hartmann K
FIR - Hartmann, Kathie
EDAT- 2011/10/20 06:00
MHDA- 2012/05/30 06:00
CRDT- 2011/10/20 06:00
PHST- 2011/02/11 00:00 [received]
PHST- 2011/09/24 00:00 [revised]
PHST- 2011/09/27 00:00 [accepted]
PHST- 2011/10/20 06:00 [entrez]
PHST- 2011/10/20 06:00 [pubmed]
PHST- 2012/05/30 06:00 [medline]
AID - S1551-7144(11)00255-2 [pii]
AID - 10.1016/j.cct.2011.09.019 [doi]
PST - ppublish
SO  - Contemp Clin Trials. 2012 Jan;33(1):184-96. doi: 10.1016/j.cct.2011.09.019. Epub 
      2011 Oct 8.


PMID- 22008197
OWN - NLM
STAT- MEDLINE
DCOM- 20160422
LR  - 20181201
IS  - 1945-1938 (Electronic)
IS  - 1049-023X (Linking)
VI  - 26
IP  - 4
DP  - 2011 Aug
TI  - Ethical issues in disasters.
PG  - 289-92
LID - 10.1017/S1049023X1100642X [doi]
AB  - A disaster is a situation that overwhelms the local population's capacity to
      respond, thus necessitating a request for assistance from outside the impacted
      area. In these circumstances, needs usually outweigh resources. The objective of 
      response is to do the greatest good for the greatest number of people (the
      utilitarian principle). As such, some unique ethical considerations will arise
      that are not seen in day-to-day practice.The adoption of medical ethics
      principles is important in such situations, but certain provisions must be
      accepted. In large-scale, complex disasters, it may be impossible to provide
      optimal care to each patient. This paper will discuss some of the challenges for 
      healthcare personnel at "ground zero", how training in preventive ethics may
      help, and what principles can be applied when working in disaster-affected areas 
      or when responding to disasters.
FAU - Lateef, Fatimah
AU  - Lateef F
AD  - Senior Consultant, Emergency Medicine and Trauma, Director of Undergraduate
      Training and Education, Department of Emergency Medicine, Singapore General
      Hospital; Senior Clinical Lecturer, Yong Loo Lin School of Medicine, National
      University of Singapore, Senior Part-Time Lecturer, School of Health Sciences,
      Nanyang Polytechnic, Singapore.
LA  - eng
PT  - Journal Article
DEP - 20111007
PL  - United States
TA  - Prehosp Disaster Med
JT  - Prehospital and disaster medicine
JID - 8918173
MH  - Disaster Planning
MH  - *Disasters
MH  - Ethics, Medical
MH  - *Health Resources
MH  - Humans
EDAT- 2011/10/20 06:00
MHDA- 2016/04/23 06:00
CRDT- 2011/10/20 06:00
PHST- 2011/10/20 06:00 [entrez]
PHST- 2011/10/20 06:00 [pubmed]
PHST- 2016/04/23 06:00 [medline]
AID - S1049023X1100642X [pii]
AID - 10.1017/S1049023X1100642X [doi]
PST - ppublish
SO  - Prehosp Disaster Med. 2011 Aug;26(4):289-92. doi: 10.1017/S1049023X1100642X. Epub
      2011 Oct 7.


PMID- 22008185
OWN - NLM
STAT- MEDLINE
DCOM- 20120402
LR  - 20161021
IS  - 1547-5069 (Electronic)
IS  - 1527-6546 (Linking)
VI  - 43
IP  - 4
DP  - 2011 Dec
TI  - Nursing priorities, actions, and regrets for ethical situations in clinical
      practice.
PG  - 385-95
LID - 10.1111/j.1547-5069.2011.01422.x [doi]
AB  - PURPOSE: Nurses in all clinical settings encounter ethical issues that frequently
      lead to moral distress. This critical incident study explored nurses'
      descriptions of ethically difficult situations to identify priorities, action
      responses, and regrets. METHODS: Employing the critical incident technique,
      researchers developed a questionnaire that collected information on ethically
      difficult situations, nurse actions, and situational outcomes. Data on nursing
      priorities and actions were analyzed and categorized using a constant comparison 
      technique. FINDINGS: Addressing patient autonomy and quality of life were ethical
      priorities in the majority of cases. In many cases, nurses analyzed ethics from a
      diffuse perspective and only considered one dimension of the ethics conflict.
      However, some nurses were specific in their ethical analysis and proactive in
      their action choices. Nurses also identified 12 ethics-specific nurse activities,
      five ways of being, three ways of knowing, and two ways of deliberating. In 21
      cases, nurses chose not to pursue their concerns beyond providing standard care. 
      Several nurses expressed significant regret in their narration; most regretted
      unnecessary pain and suffering, and some claimed they did not do enough for the
      patient. CONCLUSIONS: Not enough specific, evidence-based ethics actions have
      been developed. Stronger and more proactive nursing voices with early ethics
      interventions would make valuable contributions to quality of care for patients, 
      especially at the end of life. CLINICAL RELEVANCE: Ever-expanding treatment
      options raise ethical issues and challenge nurses to be effective patient
      advocates. Evidence-based nursing interventions that promptly identify and
      address moral conflict will benefit patients, their families, and the entire
      healthcare team by mitigating potential moral distress and disengagement.
CI  - (c) 2011 Sigma Theta Tau International.
FAU - Pavlish, Carol
AU  - Pavlish C
AD  - UCLA School of Nursing, Los Angeles, CA 90095-6918, USA. cpavlish@sonnet.ucla.edu
FAU - Brown-Saltzman, Katherine
AU  - Brown-Saltzman K
FAU - Hersh, Mary
AU  - Hersh M
FAU - Shirk, Marilyn
AU  - Shirk M
FAU - Rounkle, Ann-Marie
AU  - Rounkle AM
LA  - eng
PT  - Journal Article
DEP - 20111018
PL  - United States
TA  - J Nurs Scholarsh
JT  - Journal of nursing scholarship : an official publication of Sigma Theta Tau
      International Honor Society of Nursing
JID - 100911591
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Bioethical Issues
MH  - *Emotions
MH  - *Ethics, Nursing
MH  - Female
MH  - Humans
MH  - Male
MH  - Nursing Methodology Research
MH  - Nursing Staff, Hospital/*psychology
MH  - Practice Patterns, Nurses'/*ethics
MH  - Stress, Psychological
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2011/10/20 06:00
MHDA- 2012/04/03 06:00
CRDT- 2011/10/20 06:00
PHST- 2011/10/20 06:00 [entrez]
PHST- 2011/10/20 06:00 [pubmed]
PHST- 2012/04/03 06:00 [medline]
AID - 10.1111/j.1547-5069.2011.01422.x [doi]
PST - ppublish
SO  - J Nurs Scholarsh. 2011 Dec;43(4):385-95. doi: 10.1111/j.1547-5069.2011.01422.x.
      Epub 2011 Oct 18.


PMID- 22008164
OWN - NLM
STAT- MEDLINE
DCOM- 20120319
LR  - 20111019
IS  - 1754-9485 (Electronic)
IS  - 1754-9477 (Linking)
VI  - 55
IP  - 5
DP  - 2011 Oct
TI  - Impact of breast MR in non-screening Australian clinical practice: audit data
      from a single-reader single-centre site.
PG  - 461-73
LID - 10.1111/j.1754-9485.2011.02302.x [doi]
AB  - AIM: The aim of this study was to evaluate the accuracy and clinical impact of
      single-reader breast MR (BMR) used as a clinical 'problem solving' tool. METHODS:
      Observational, retrospective, ethics approved data collection for all BMR were
      from May 2006 to February 2009 (n=143). Cases were stratified into groups
      according to indication for referral. MR data included single-reader MR diagnosis
      and breast imaging reporting and data system category (per-patient basis), MR
      descriptors of lesions (breast imaging reporting and data system lexicon), lesion
      number and location. Composite reference standard was established from surgical
      histology, core histology, cytology, MR imaging follow-up, conventional imaging
      follow-up and clinical follow-up in that order of priority. Impact was
      qualitatively captured by estimating change in management as the result of BMR.
      RESULTS: Eighty-two cases were included and 61 were excluded (41 insufficient
      follow-up times, three known benign mass for clarification, two worried well
      screening and 15 other reasons). There was no statistically significant
      difference in included and excluded patient profiles. Our largest group of
      referrals was of patients with suspicious or unhelpful conventional imaging. BMR 
      identified five malignancies in that group but missed four. In our smaller group 
      of patients with metastatic axillary lymph nodes, BMR identified the occult
      primary cancer in all five cases. CONCLUSION: In this 'problem solving' patient
      population, breast MR shows greatest impact in patients with carcinoma metastases
      to axillary nodes, but primary not visible. In symptomatic women with unhelpful
      imaging or with suspicious imaging but no pre-MR diagnosis, MR identified 5/41
      carcinomas, but missed 4/41.
CI  - (c) 2011 The Authors. Journal of Medical Imaging and Radiation Oncology (c) 2011 
      The Royal Australian and New Zealand College of Radiologists.
FAU - El-Barhoun, Esber N
AU  - El-Barhoun EN
AD  - Flinders Medical Centre, Department of Radiology, Adelaide, South Australia,
      Australia. esberelbarhoun@yahoo.com.au
FAU - Pitman, Alexander G
AU  - Pitman AG
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Med Imaging Radiat Oncol
JT  - Journal of medical imaging and radiation oncology
JID - 101469340
SB  - IM
MH  - Adult
MH  - Aged
MH  - Australia
MH  - Breast/pathology
MH  - Breast Diseases/*pathology
MH  - Breast Neoplasms/pathology
MH  - Diagnosis, Differential
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
EDAT- 2011/10/20 06:00
MHDA- 2012/03/20 06:00
CRDT- 2011/10/20 06:00
PHST- 2011/10/20 06:00 [entrez]
PHST- 2011/10/20 06:00 [pubmed]
PHST- 2012/03/20 06:00 [medline]
AID - 10.1111/j.1754-9485.2011.02302.x [doi]
PST - ppublish
SO  - J Med Imaging Radiat Oncol. 2011 Oct;55(5):461-73. doi:
      10.1111/j.1754-9485.2011.02302.x.


PMID- 22007979
OWN - NLM
STAT- MEDLINE
DCOM- 20120326
LR  - 20220408
IS  - 1365-2214 (Electronic)
IS  - 0305-1862 (Linking)
VI  - 37
IP  - 6
DP  - 2011 Nov
TI  - Sustainable transition process for young people with chronic conditions: a
      narrative summary on achieved cooperation between paediatric and adult medical
      teams.
PG  - 800-5
LID - 10.1111/j.1365-2214.2011.01330.x [doi]
AB  - BACKGROUND: Transfer of young people (YP) with chronic conditions to
      adult-centred multi-professional care (AdCC) has been discussed for decades.
      Generic principles for transition have been proposed, but resulting outcomes have
      not, on the whole, been documented and the burden of ensuring suitable transition
      continues to lie in the field of paediatrics. The emerging knowledge of the brain
      maturing into the twenties together with the enforced transfer of patients at
      18.0 years of age has made paediatric clinics in Sweden reconsider their
      transition protocols. METHODS: Paediatrics-centred multi-professional care
      (PedCC) teams and AdCC teams in one administrative area participated in joint
      small group discussions on principles for transition during 2 days. The suggested
      principles were then given to next group in another administrative area for
      evaluation and elaboration. Thirteen such seminars with small group discussions
      took place consecutively. RESULTS: After this process, six core principles
      emerged as acceptable and essential. 1 The age of 18.0 was accepted as a
      reasonable age for the transfer of all patients from PedCC to AdCC. 2 A draft was
      developed of the knowledge and skills that PedCC should teach patients and
      parents before age 18, to make transfer viable. 3 A draft was made of the
      psychosocial needs of YP for the latter part of transition, which would be the
      responsibility of AdCC. 4 A self-referral note was developed, where patients
      present their own needs. 5 YP dropping out of needed care after transfer was
      considered a violation of ethical codes that required finite action. 6 Joint
      small group discussions between PedCC and AdCC were found to be instrumental for 
      cooperation. Follow-up seminars demonstrated sustainability and spontaneous
      spreading of the principles. CONCLUSION: Small group discussions between PedCC
      and AdCC were pivotal in creating a sustainable process for transition. It was
      possible to agree on six core principles and share the responsibility between
      PedCC and AdCC.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Berg Kelly, K
AU  - Berg Kelly K
AD  - Goteborg University, and Department for the Health of Women and Children, The
      Queen Silvia Children's Hospital, Goteborg, Sweden. kristina@bob-kelly.se
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Child Care Health Dev
JT  - Child: care, health and development
JID - 7602632
SB  - IM
MH  - Adolescent
MH  - Adolescent Behavior
MH  - Adolescent Development
MH  - Adolescent Medicine
MH  - Age Factors
MH  - Child
MH  - Child Development
MH  - *Chronic Disease
MH  - *Cooperative Behavior
MH  - Delivery of Health Care/organization & administration
MH  - Education
MH  - Ethics, Medical
MH  - Female
MH  - Humans
MH  - Male
MH  - *Narration
MH  - Patient Care Team/*organization & administration
MH  - *Pediatrics
MH  - Sweden
MH  - Time Factors
MH  - Young Adult
EDAT- 2011/10/20 06:00
MHDA- 2012/03/27 06:00
CRDT- 2011/10/20 06:00
PHST- 2011/10/20 06:00 [entrez]
PHST- 2011/10/20 06:00 [pubmed]
PHST- 2012/03/27 06:00 [medline]
AID - 10.1111/j.1365-2214.2011.01330.x [doi]
PST - ppublish
SO  - Child Care Health Dev. 2011 Nov;37(6):800-5. doi:
      10.1111/j.1365-2214.2011.01330.x.


PMID- 22007842
OWN - NLM
STAT- MEDLINE
DCOM- 20120827
LR  - 20120426
IS  - 1465-3656 (Electronic)
IS  - 1355-4794 (Linking)
VI  - 18
IP  - 3
DP  - 2012 Jun
TI  - Better evidence for safety and efficacy is needed before neurologists prescribe
      drugs for neuroenhancement to healthy people.
PG  - 181-4
LID - 10.1080/13554794.2011.588174 [doi]
AB  - In this paper we question the guidance offered to neurologists by the Ethics, Law
      and Humanities Committee of the American Academy of Neurology (Larriviere,
      Williams, Rizzo & Bonnie, 2009) on how to respond to requests for
      "neuroenhancement": the use of pharmaceuticals to enhance cognitive function in
      cognitively normal people. The guidance assumes that the benefits of using
      neuroenhancers will prove to outweigh the risks in the absence of any evidence
      that this is the case. However, the principle of nonmaleficence dictates that the
      use of these drugs by healthy people should not be condoned before reliable
      evidence for their short and long term safety and efficacy is at hand. The
      proposed ethical framework for neuroenhancement prescribing also neglects the
      broader social implications of condoning such practices. The adoption of these
      guidelines by neurologists could have adverse social and medical effects that
      need to be more carefully considered.
FAU - Boot, Brendon P
AU  - Boot BP
AD  - Department of Neurology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.
      bboot@med.usyd.edu.au
FAU - Partridge, Brad
AU  - Partridge B
FAU - Hall, Wayne
AU  - Hall W
LA  - eng
PT  - Journal Article
DEP - 20111018
PL  - England
TA  - Neurocase
JT  - Neurocase
JID - 9511374
RN  - 0 (Nootropic Agents)
SB  - IM
MH  - *Biomedical Enhancement/ethics/methods/standards
MH  - Cognition/*drug effects
MH  - *Drug Prescriptions/standards
MH  - Humans
MH  - Neurology/*ethics
MH  - Nootropic Agents/*pharmacology
EDAT- 2011/10/20 06:00
MHDA- 2012/08/28 06:00
CRDT- 2011/10/20 06:00
PHST- 2011/10/20 06:00 [entrez]
PHST- 2011/10/20 06:00 [pubmed]
PHST- 2012/08/28 06:00 [medline]
AID - 10.1080/13554794.2011.588174 [doi]
PST - ppublish
SO  - Neurocase. 2012 Jun;18(3):181-4. doi: 10.1080/13554794.2011.588174. Epub 2011 Oct
      18.


PMID- 22007560
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20191112
IS  - 0745-5194 (Print)
IS  - 0745-5194 (Linking)
VI  - 25
IP  - 3
DP  - 2011 Sep
TI  - Do "illegal" im/migrants have a right to health? Engaging ethical theory as
      social practice at a Tel Aviv open clinic.
PG  - 303-30
AB  - As the notion of a "right to health" gains influence, it is increasingly deployed
      in ways that are diverse, contextually variable, and at times logically
      inconsistent. Drawing on extended fieldwork at an Israeli human rights
      organization that advocates for "illegal" migrants and other vulnerable groups,
      this article contends that medical anthropologists cannot simply rally behind
      this right. Instead, we must take it as an object of ethnographic analysis and
      explore bow it is invoked, debated, and resisted in specific contexts. Critical
      ethnographies of right to health discourse and practice can enlighten us, and
      help us enlighten scholars in other fields, to the complexity, messiness, and
      "mushiness" (Sen 2009) of this right, especially in the context of advocacy on
      unauthorized im/migrants' behalf. It can also deepen understanding of the
      complicated and sometimes tense relationships among human rights,
      humanitarianism, and other contemporary idioms of social justice mobilization,
      especially in the health domain.
FAU - Willen, Sarah S
AU  - Willen SS
AD  - Department of Anthropology, University of Connecticut, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Med Anthropol Q
JT  - Medical anthropology quarterly
JID - 8405037
SB  - IM
MH  - Ambulatory Care Facilities
MH  - *Ethical Theory
MH  - *Human Rights
MH  - Humans
MH  - Israel
MH  - Patient Rights/*ethics
MH  - Social Problems
MH  - *Transients and Migrants
EDAT- 2011/10/20 06:00
MHDA- 2011/11/09 06:00
CRDT- 2011/10/20 06:00
PHST- 2011/10/20 06:00 [entrez]
PHST- 2011/10/20 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - 10.1111/j.1548-1387.2011.01163.x [doi]
PST - ppublish
SO  - Med Anthropol Q. 2011 Sep;25(3):303-30. doi: 10.1111/j.1548-1387.2011.01163.x.


PMID- 22007240
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1687-9678 (Electronic)
VI  - 2011
DP  - 2011
TI  - Generation of Induced Pluripotent Stem (iPS) Cells by Nuclear Reprogramming.
PG  - 619583
LID - 10.4061/2011/619583 [doi]
AB  - During embryonic development pluripotency is progressively lost irreversibly by
      cell division, differentiation, migration and organ formation. Terminally
      differentiated cells do not generate other kinds of cells. Pluripotent stem cells
      are a great source of varying cell types that are used for tissue regeneration or
      repair of damaged tissue. The pluripotent stem cells can be derived from inner
      cell mass of blastocyte but its application is limited due to ethical concerns.
      The recent discovery of iPS with defined reprogramming factors has initiated a
      flurry of works on stem cell in various laboratories. The pluripotent cells can
      be derived from various differentiated adult cells as well as from adult stem
      cells by nuclear reprogramming, somatic cell nuclear transfer etc. In this review
      article, different aspects of nuclear reprogramming are discussed.
FAU - Dey, Dilip
AU  - Dey D
AD  - Aesthetic and Plastic Surgery Institute, University of California, Irvine,
      Orange, CA 92868, USA.
FAU - Evans, Gregory R D
AU  - Evans GR
LA  - eng
PT  - Journal Article
DEP - 20111005
PL  - United States
TA  - Stem Cells Int
JT  - Stem cells international
JID - 101535822
PMC - PMC3189620
EDAT- 2011/10/19 06:00
MHDA- 2011/10/19 06:01
CRDT- 2011/10/19 06:00
PHST- 2011/03/16 00:00 [received]
PHST- 2011/06/18 00:00 [revised]
PHST- 2011/06/22 00:00 [accepted]
PHST- 2011/10/19 06:00 [entrez]
PHST- 2011/10/19 06:00 [pubmed]
PHST- 2011/10/19 06:01 [medline]
AID - 10.4061/2011/619583 [doi]
PST - ppublish
SO  - Stem Cells Int. 2011;2011:619583. doi: 10.4061/2011/619583. Epub 2011 Oct 5.


PMID- 22006081
OWN - NLM
STAT- MEDLINE
DCOM- 20120601
LR  - 20161125
IS  - 1476-5624 (Electronic)
IS  - 1362-4393 (Linking)
VI  - 50
IP  - 2
DP  - 2012 Feb
TI  - How do spinal cord injury centres manage malnutrition? A cross-sectional survey
      of 12 regional centres in the United Kingdom and Ireland.
PG  - 132-5
LID - 10.1038/sc.2011.118 [doi]
AB  - STUDY DESIGN: A multi-centre, cross-sectional survey. OBJECTIVES: To establish
      and compare the resources allocated against existing national standards, and to
      document current nutritional screening practices. SETTING: Spinal cord injury
      centres (SCICs) in the United Kingdom and the Republic of Ireland. METHODS: After
      obtaining research ethics committee approval, 12 SCICs in the United Kingdom and 
      the Republic of Ireland were surveyed by a postal questionnaire. Data collected
      included the number of whole time equivalent (WTE) staff available, whether a
      nutrition team was present and the use of nutritional screening tools in the
      SCIC. RESULTS: Eleven (92%) SCICs responded. In total there were 482 allocated
      beds, and the average numbers of patients per WTE staff (s.d.), including
      consultants, nurses, dietitians, physiotherapists, occupational therapists and
      psychologists, were recorded. Eight centres used a nutritional screening tool,
      and only two centres had a clinical nutrition team. CONCLUSION: The resources
      allocated to nutritional care in SCICs appear to be very limited. This suggests
      that malnutrition will continue to be under-recognised and under-treated. There
      is a clear need for additional resources to address the nutritional needs of this
      special population group. Each SCIC should ensure regular access to nutritional
      advice, and the establishment of local nutrition support teams should be a
      priority.
FAU - Wong, S
AU  - Wong S
AD  - Department of Nutrition and Dietetics, Stoke Mandeville Hospital, London, UK.
      Samford.Wong@ucl.ac.uk
FAU - Derry, F
AU  - Derry F
FAU - Grimble, G
AU  - Grimble G
FAU - Forbes, A
AU  - Forbes A
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20111018
PL  - England
TA  - Spinal Cord
JT  - Spinal cord
JID - 9609749
SB  - IM
MH  - Cross-Sectional Studies
MH  - Humans
MH  - Ireland
MH  - Malnutrition/*diagnosis/etiology
MH  - Nutritional Status
MH  - Nutritional Support/standards
MH  - Physical Therapists
MH  - Spinal Cord Injuries/*complications/rehabilitation
MH  - Surveys and Questionnaires
MH  - United Kingdom
EDAT- 2011/10/19 06:00
MHDA- 2012/06/02 06:00
CRDT- 2011/10/19 06:00
PHST- 2011/10/19 06:00 [entrez]
PHST- 2011/10/19 06:00 [pubmed]
PHST- 2012/06/02 06:00 [medline]
AID - sc2011118 [pii]
AID - 10.1038/sc.2011.118 [doi]
PST - ppublish
SO  - Spinal Cord. 2012 Feb;50(2):132-5. doi: 10.1038/sc.2011.118. Epub 2011 Oct 18.


PMID- 22005110
OWN - NLM
STAT- MEDLINE
DCOM- 20120328
LR  - 20131121
IS  - 1815-7920 (Electronic)
IS  - 1027-3719 (Linking)
VI  - 15
IP  - 12
DP  - 2011 Dec
TI  - Xpert(R) MTB/RIF for national tuberculosis programmes in low-income countries:
      when, where and how?
PG  - 1567-72
LID - 10.5588/ijtld.11.0392 [doi]
AB  - Xpert (R) MTB/RIF offers new and important possibilities for the diagnosis of
      sputum smear-negative tuberculosis (TB) and/or rifampicin (RMP) resistance, and
      many are encouraging rapid and widespread implementation. This simple test can be
      implemented almost everywhere, and it provides results within a few hours. In
      low-income countries (LICs), however, its cost, environmental limitations (stable
      and regular electricity, adequate room temperature) and difficulties involved in 
      supply and maintenance are major obstacles. While it may be suitable for major
      reference hospitals, operational research is needed to evaluate the test and its 
      additional yield above high-quality smear microscopy and clinical algorithms
      before its use at the peripheral level. In the meantime, direct microscopy should
      remain the initial diagnostic test for TB suspects. In most LICs, the prevalence 
      of RMP resistance among new TB patients is very low; an Xpert MTB/RIF result
      indicating RMP resistance will thus always need confirmation by another test. In 
      a population at high risk of RMP resistance (> 15%), however, the positive
      predictive value for RMP resistance by Xpert MTB/RIF is high, and identification 
      of RMP resistance is an excellent proxy for multidrug-resistant TB (MDR-TB). The 
      assay should be widely used for this purpose if, and only if, excellent MDR-TB
      management is available, both for ethical reasons and to reduce the risk of
      extensively drug-resistant TB.
FAU - Trebucq, A
AU  - Trebucq A
AD  - Institute of International Union Against Tuberculosis and Lung Disease, Paris,
      France. atrebucq@theunion.org
FAU - Enarson, D A
AU  - Enarson DA
FAU - Chiang, C Y
AU  - Chiang CY
FAU - Van Deun, A
AU  - Van Deun A
FAU - Harries, A D
AU  - Harries AD
FAU - Boillot, F
AU  - Boillot F
FAU - Detjen, A
AU  - Detjen A
FAU - Fujiwara, P I
AU  - Fujiwara PI
FAU - Graham, S M
AU  - Graham SM
FAU - Monedero, I
AU  - Monedero I
FAU - Rusen, I D
AU  - Rusen ID
FAU - Rieder, H L
AU  - Rieder HL
LA  - eng
PT  - Journal Article
DEP - 20111013
PL  - France
TA  - Int J Tuberc Lung Dis
JT  - The international journal of tuberculosis and lung disease : the official journal
      of the International Union against Tuberculosis and Lung Disease
JID - 9706389
RN  - 0 (Antitubercular Agents)
RN  - VJT6J7R4TR (Rifampin)
SB  - IM
CIN - Int J Tuberc Lung Dis. 2011 Dec;15(12):1563. PMID: 22118160
CIN - Int J Tuberc Lung Dis. 2012 May;16(5):701; author reply 702. PMID: 22507934
CIN - Int J Tuberc Lung Dis. 2012 May;16(5):702-3; author reply 703-4. PMID: 22507936
MH  - Algorithms
MH  - Antitubercular Agents/*pharmacology
MH  - Developing Countries
MH  - Drug Resistance, Bacterial
MH  - Humans
MH  - Microbial Sensitivity Tests
MH  - Mycobacterium tuberculosis/drug effects
MH  - National Health Programs
MH  - Nucleic Acid Amplification Techniques/economics/*methods
MH  - Rifampin/*pharmacology
MH  - Sputum/microbiology
MH  - Tuberculosis/*diagnosis/drug therapy/microbiology
EDAT- 2011/10/19 06:00
MHDA- 2012/03/29 06:00
CRDT- 2011/10/19 06:00
PHST- 2011/10/19 06:00 [entrez]
PHST- 2011/10/19 06:00 [pubmed]
PHST- 2012/03/29 06:00 [medline]
AID - 0392 [pii]
AID - 10.5588/ijtld.11.0392 [doi]
PST - ppublish
SO  - Int J Tuberc Lung Dis. 2011 Dec;15(12):1567-72. doi: 10.5588/ijtld.11.0392. Epub 
      2011 Oct 13.


PMID- 22004770
OWN - NLM
STAT- MEDLINE
DCOM- 20120827
LR  - 20111018
IS  - 1471-6348 (Electronic)
IS  - 0266-4623 (Linking)
VI  - 27
IP  - 4
DP  - 2011 Oct
TI  - Different methods for ethical analysis in health technology assessment: an
      empirical study.
PG  - 305-12
LID - 10.1017/S0266462311000444 [doi]
AB  - OBJECTIVES: Ethical analysis can highlight important ethical issues related to
      implementing a technology, values inherent in the technology itself, and
      value-decisions underlying the health technology assessment (HTA) process.
      Ethical analysis is a well-acknowledged part of HTA, yet seldom included in
      practice. One reason for this is lack of knowledge about the properties and
      differences between the methods available. This study compares different methods 
      for ethical analysis within HTA. METHODS: Ethical issues related to bariatric
      (obesity) surgery were independently evaluated using axiological, casuist,
      principlist, and EUnetHTA models for ethical analysis within HTA. The methods and
      results are presented and compared. RESULTS: Despite varying theoretical
      underpinnings and practical approaches, the four methods identified similar
      themes: personal responsibility, self-infliction, discrimination, justice, public
      funding, and stakeholder involvement. The axiological and EUnetHTA models
      identified a wider range of arguments, whereas casuistry and principlism
      concentrated more on analyzing a narrower set of arguments deemed more important.
      CONCLUSIONS: Different methods can be successfully used for conducting ethical
      analysis within HTA. Although our study does not show that different methods in
      ethics always produce similar results, it supports the view that different
      methods of ethics can yield relevantly similar results. This suggests that the
      key conclusions of ethical analyses within HTA can be transferable between
      methods and countries. The systematic and transparent use of some method of
      ethics appears more important than the choice of the exact method.
FAU - Saarni, Samuli I
AU  - Saarni SI
AD  - National Institute for Health and Welfare, Department of Mental Health and
      Finnish Office for Health Technology Assessment, PO Box 30, 00271 Helsinki,
      Finland. Samuli.saarni@helsinki.fi
FAU - Braunack-Mayer, Annette
AU  - Braunack-Mayer A
FAU - Hofmann, Bjorn
AU  - Hofmann B
FAU - van der Wilt, Gert Jan
AU  - van der Wilt GJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Technol Assess Health Care
JT  - International journal of technology assessment in health care
JID - 8508113
SB  - IM
CIN - Int J Technol Assess Health Care. 2012 Apr;28(2):195-6; author reply 196-7. PMID:
      22559764
MH  - Bariatric Surgery/*economics/*ethics
MH  - Casuistry
MH  - *Ethical Analysis
MH  - *Financing, Government
MH  - Humans
MH  - Morals
MH  - Technology Assessment, Biomedical/*organization & administration
EDAT- 2011/10/19 06:00
MHDA- 2012/08/28 06:00
CRDT- 2011/10/19 06:00
PHST- 2011/10/19 06:00 [entrez]
PHST- 2011/10/19 06:00 [pubmed]
PHST- 2012/08/28 06:00 [medline]
AID - S0266462311000444 [pii]
AID - 10.1017/S0266462311000444 [doi]
PST - ppublish
SO  - Int J Technol Assess Health Care. 2011 Oct;27(4):305-12. doi:
      10.1017/S0266462311000444.


PMID- 22004391
OWN - NLM
STAT- MEDLINE
DCOM- 20111214
LR  - 20190902
IS  - 1326-5377 (Electronic)
IS  - 0025-729X (Linking)
VI  - 195
IP  - 8
DP  - 2011 Oct 17
TI  - Is it ethical for medical practitioners to prescribe alternative and
      complementary treatments that may lack an evidence base?
PG  - 450-2
FAU - Gerber, Paul
AU  - Gerber P
LA  - eng
PT  - Letter
PT  - Comment
PL  - Australia
TA  - Med J Aust
JT  - The Medical journal of Australia
JID - 0400714
SB  - IM
CON - Med J Aust. 2011 Jul 18;195(2):78. PMID: 21770875
MH  - Complementary Therapies/*ethics
MH  - Evidence-Based Medicine/*ethics
MH  - Humans
EDAT- 2011/10/19 06:00
MHDA- 2011/12/15 06:00
CRDT- 2011/10/19 06:00
PHST- 2011/07/25 00:00 [received]
PHST- 2011/08/03 00:00 [accepted]
PHST- 2011/10/19 06:00 [entrez]
PHST- 2011/10/19 06:00 [pubmed]
PHST- 2011/12/15 06:00 [medline]
AID - letters_171011_fm-5 [pii]
AID - 10.5694/mja11.10923 [doi]
PST - ppublish
SO  - Med J Aust. 2011 Oct 17;195(8):450-2. doi: 10.5694/mja11.10923.


PMID- 22004344
OWN - NLM
STAT- MEDLINE
DCOM- 20120710
LR  - 20211020
IS  - 1471-2474 (Electronic)
IS  - 1471-2474 (Linking)
VI  - 12
DP  - 2011 Oct 17
TI  - Amsterdam wrist rules: a clinical decision aid.
PG  - 238
LID - 10.1186/1471-2474-12-238 [doi]
AB  - BACKGROUND: Acute trauma of the wrist is one of the most frequent reasons for
      visiting the Emergency Department. These patients are routinely referred for
      radiological examination. Most X-rays however, do not reveal any fractures. A
      clinical decision rule determining the need for X-rays in patients with acute
      wrist trauma may help to percolate and select patients with fractures.
      METHODS/DESIGN: This study will be a multi-center observational diagnostic study 
      in which the data will be collected cross-sectionally. The study population will 
      consist of all consecutive adult patients (>/=18 years) presenting with acute
      wrist trauma at the Emergency Department in the participating hospitals. This
      research comprises two components: one study will be conducted to determine which
      clinical parameters are predictive for the presence of a distal radius fracture
      in adult patients presenting to the Emergency Department following acute wrist
      trauma. These clinical parameters are defined by trauma-mechanism, physical
      examination, and functional testing. This data will be collected in two of the
      three participating hospitals and will be assessed by using logistic regression
      modelling to estimate the regression coefficients after which a reduced model
      will be created by means of a log likelihood ratio test. The accuracy of the
      model will be estimated by a goodness of fit test and an ROC curve. The final
      model will be validated internally through bootstrapping and by shrinking it, an 
      adjusted model will be generated. In the second component of this study, the
      developed prediction model will be validated in a new dataset consisting of a
      population of patients from the third hospital. If necessary, the model will be
      calibrated using the data from the validation study. DISCUSSION: Wrist trauma is 
      frequently encountered at the Emergency Department. However, to this date, no
      decision rule regarding this type of trauma has been created. Ideally,
      radiographs are obtained of all patients entering one of the participating
      hospitals with trauma to the wrist. However, this is ethically and logistically
      not feasible and one could argue that patients, for whom no radiography is
      required according to their physician, are not suspected of having a distal
      radius fracture and thus are not part of the domain. TRIAL REGISTRATION: This
      study is registered at the Netherlands Trial Register (NTR 2544) and was granted 
      permission by the Medical Ethical Committee of the Academic Medical Center
      Amsterdam on 06-01-2011.
FAU - Bentohami, Abdelali
AU  - Bentohami A
AD  - Trauma Unit, Department of Surgery, Academic Medical Center, University of
      Amsterdam, P.O. Box 22660, 1100 DD Amsterdam, The Netherlands.
FAU - Walenkamp, Monique M J
AU  - Walenkamp MM
FAU - Slaar, Annelie
AU  - Slaar A
FAU - Beerekamp, M Suzan H
AU  - Beerekamp MS
FAU - de Groot, Joris A H
AU  - de Groot JA
FAU - Verhoog, Eva M
AU  - Verhoog EM
FAU - Jager, L Cara
AU  - Jager LC
FAU - Maas, Mario
AU  - Maas M
FAU - Bijlsma, Taco S
AU  - Bijlsma TS
FAU - van Dijkman, Bart A
AU  - van Dijkman BA
FAU - Schep, Niels W L
AU  - Schep NW
FAU - Goslings, J Carel
AU  - Goslings JC
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Validation Study
DEP - 20111017
PL  - England
TA  - BMC Musculoskelet Disord
JT  - BMC musculoskeletal disorders
JID - 100968565
SB  - IM
EIN - BMC Musculoskelet Disord. 2013;14:95. Goslings, Carel J [corrected to Goslings, J
      Carel]
MH  - Acute Disease
MH  - Adult
MH  - Arthrography/*standards
MH  - Diagnosis, Differential
MH  - Emergency Medical Services/*standards
MH  - Humans
MH  - Netherlands
MH  - Patient Selection
MH  - Radius Fractures/*diagnostic imaging
MH  - Research Design/*standards
MH  - Wrist Injuries/*diagnosis/*diagnostic imaging/physiopathology
PMC - PMC3229467
EDAT- 2011/10/19 06:00
MHDA- 2012/07/11 06:00
CRDT- 2011/10/19 06:00
PHST- 2011/03/16 00:00 [received]
PHST- 2011/10/17 00:00 [accepted]
PHST- 2011/10/19 06:00 [entrez]
PHST- 2011/10/19 06:00 [pubmed]
PHST- 2012/07/11 06:00 [medline]
AID - 1471-2474-12-238 [pii]
AID - 10.1186/1471-2474-12-238 [doi]
PST - epublish
SO  - BMC Musculoskelet Disord. 2011 Oct 17;12:238. doi: 10.1186/1471-2474-12-238.


PMID- 22004337
OWN - NLM
STAT- MEDLINE
DCOM- 20120629
LR  - 20211020
IS  - 1939-0599 (Electronic)
IS  - 0012-1649 (Linking)
VI  - 48
IP  - 2
DP  - 2012 Mar
TI  - The BlackBerry project: capturing the content of adolescents' text messaging.
PG  - 295-302
LID - 10.1037/a0025914 [doi]
AB  - This article presents an innovative method for capturing the content of
      adolescents' electronic communication on handheld devices: text messaging,
      e-mail, and instant messaging. In an ongoing longitudinal study, adolescents were
      provided with BlackBerry devices with service plans paid for by the
      investigators, and use of text messaging was examined when participants were 15
      years old and in the 10th grade (N = 175; 81 girls). BlackBerries were configured
      so that the content of all text messages, e-mail messages, and instant messages
      was saved to a secure server and organized in a highly secure, searchable, online
      archive. This article describes the technology used to devise this method and
      ethical considerations. Evidence for validity is presented, including both
      information on use of text messaging to show that participants used these devices
      heavily and frequencies of profane and sexual language in a 2-day sample of text 
      messaging to demonstrate that they were communicating openly.
CI  - PsycINFO Database Record (c) 2012 APA, all rights reserved.
FAU - Underwood, Marion K
AU  - Underwood MK
AD  - School of Behavioral and Brain Sciences, The University of Texas at Dallas,
      Richardson, TX 75080, USA. undrwd@utdallas.edu
FAU - Rosen, Lisa H
AU  - Rosen LH
FAU - More, David
AU  - More D
FAU - Ehrenreich, Samuel E
AU  - Ehrenreich SE
FAU - Gentsch, Joanna K
AU  - Gentsch JK
LA  - eng
GR  - R56 MH063076/MH/NIMH NIH HHS/United States
GR  - R01 MH063076-05/MH/NIMH NIH HHS/United States
GR  - R01 MH063076/MH/NIMH NIH HHS/United States
GR  - R01 HD060995-09/HD/NICHD NIH HHS/United States
GR  - R01 MH063076-04/MH/NIMH NIH HHS/United States
GR  - K02 MH073616/MH/NIMH NIH HHS/United States
GR  - R01 MH063076-01A2/MH/NIMH NIH HHS/United States
GR  - K02 MH073616-05/MH/NIMH NIH HHS/United States
GR  - R01 MH063076-02/MH/NIMH NIH HHS/United States
GR  - R56 MH063076-06A1/MH/NIMH NIH HHS/United States
GR  - R01 HD060995-06A2/HD/NICHD NIH HHS/United States
GR  - R01 HD060995/HD/NICHD NIH HHS/United States
GR  - R01 MH063076-03/MH/NIMH NIH HHS/United States
GR  - R01 HD060995-07/HD/NICHD NIH HHS/United States
GR  - R01 HD060995-08/HD/NICHD NIH HHS/United States
GR  - R01 MH63076/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20111017
PL  - United States
TA  - Dev Psychol
JT  - Developmental psychology
JID - 0260564
SB  - IM
MH  - Adolescent
MH  - Adolescent Behavior/*psychology
MH  - Electronic Mail
MH  - Female
MH  - Humans
MH  - Language
MH  - Longitudinal Studies
MH  - Male
MH  - Parent-Child Relations
MH  - *Psychology, Adolescent
MH  - Retrospective Studies
MH  - Sex Factors
MH  - Surveys and Questionnaires
MH  - *Text Messaging/economics/statistics & numerical data
PMC - PMC3289770
MID - NIHMS342526
EDAT- 2011/10/19 06:00
MHDA- 2012/06/30 06:00
CRDT- 2011/10/19 06:00
PHST- 2011/10/19 06:00 [entrez]
PHST- 2011/10/19 06:00 [pubmed]
PHST- 2012/06/30 06:00 [medline]
AID - 2011-23766-001 [pii]
AID - 10.1037/a0025914 [doi]
PST - ppublish
SO  - Dev Psychol. 2012 Mar;48(2):295-302. doi: 10.1037/a0025914. Epub 2011 Oct 17.


PMID- 22004169
OWN - NLM
STAT- MEDLINE
DCOM- 20130114
LR  - 20120731
IS  - 1939-2222 (Electronic)
IS  - 0022-1015 (Linking)
VI  - 141
IP  - 3
DP  - 2012 Aug
TI  - The end justifies the means, but only in the middle.
PG  - 570-83
LID - 10.1037/a0025928 [doi]
AB  - Achieving goals often requires the completion of sequential actions, such as
      finishing a series of assignments to pass a class. In the course of pursuing such
      goals, people can decide how closely to follow their personal standards for each 
      action. We propose that actions at the beginning and end of a sequence appear
      more diagnostic of the pursuer's personal standards than do actions in the
      middle. Therefore, people are more likely to adhere to their standards at the
      beginning and end of goal pursuit-and slack in the middle. We demonstrate this
      pattern of judgment and behavior in adherence to ethical standards (e.g.,
      cheating), religious traditions (e.g., skipping religious rituals), and
      performance standards (e.g., "cutting corners" on a task). We also show that the 
      motivation to adhere to standards by using proper means is independent and
      follows a different pattern from the motivation to reach the end state of goal
      pursuit.
CI  - (PsycINFO Database Record (c) 2012 APA, all rights reserved).
FAU - Toure-Tillery, Maferima
AU  - Toure-Tillery M
AD  - Booth School of Business, University of Chicago, 5807 South Woodlawn Avenue,
      Chicago, IL 60637, USA. mtt@chicagobooth.edu
FAU - Fishbach, Ayelet
AU  - Fishbach A
LA  - eng
PT  - Journal Article
DEP - 20111017
PL  - United States
TA  - J Exp Psychol Gen
JT  - Journal of experimental psychology. General
JID - 7502587
SB  - IM
MH  - Achievement
MH  - Female
MH  - Humans
MH  - Judgment/*ethics
MH  - Male
MH  - *Morals
MH  - Motivation/*ethics
EDAT- 2011/10/19 06:00
MHDA- 2013/01/15 06:00
CRDT- 2011/10/19 06:00
PHST- 2011/10/19 06:00 [entrez]
PHST- 2011/10/19 06:00 [pubmed]
PHST- 2013/01/15 06:00 [medline]
AID - 2011-23886-001 [pii]
AID - 10.1037/a0025928 [doi]
PST - ppublish
SO  - J Exp Psychol Gen. 2012 Aug;141(3):570-83. doi: 10.1037/a0025928. Epub 2011 Oct
      17.


PMID- 22003420
OWN - NLM
STAT- MEDLINE
DCOM- 20120209
LR  - 20211020
IS  - 1940-0640 (Electronic)
IS  - 1940-0632 (Linking)
VI  - 6
IP  - 1
DP  - 2011 Jul
TI  - Ethical concerns related to developing pharmacogenomic treatment strategies for
      addiction.
PG  - 32-43
AB  - Pharmacogenomics (PGx) research is poised to enable physicians to identify
      optimally effective treatments for individual substance abusers based on their
      genetic profiles. This paper addresses ethical issues related to PGx treatment
      strategies for addiction, focusing especially on the use of race variables in
      genomics research and ensuring equitable access to novel PGx treatments. Unless
      the field addresses the ethical challenges posed by these issues, PGx treatment
      innovations for addiction threaten to exacerbate already dramatic disparities in 
      the burden of drug dependence for minority and other underserved populations.
FAU - Shields, Alexandra E
AU  - Shields AE
AD  - Harvard/MGH Center for Genomics, Vulnerable Populations, and Health Disparities, 
      Mongan Institute for Health Policy Massachusetts General Hospital, Boston,
      Massachusetts, USA. ashields@partners.org
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Addict Sci Clin Pract
JT  - Addiction science & clinical practice
JID - 101316917
SB  - IM
MH  - African Americans
MH  - Databases, Genetic
MH  - Genetic Heterogeneity
MH  - Genetic Privacy
MH  - Genetic Testing
MH  - Humans
MH  - Pharmacogenetics/*ethics
MH  - Prejudice
MH  - Substance-Related Disorders/*ethnology/*genetics
MH  - United States/epidemiology
PMC - PMC3188829
EDAT- 2011/10/18 06:00
MHDA- 2012/02/10 06:00
CRDT- 2011/10/18 06:00
PHST- 2011/10/18 06:00 [entrez]
PHST- 2011/10/18 06:00 [pubmed]
PHST- 2012/02/10 06:00 [medline]
PST - ppublish
SO  - Addict Sci Clin Pract. 2011 Jul;6(1):32-43.


PMID- 22003367
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1757-5931 (Electronic)
IS  - 1757-5931 (Linking)
VI  - 3
DP  - 2011
TI  - Anti-addiction vaccines.
PG  - 20
LID - 10.3410/M3-20 [doi]
AB  - Despite intensive efforts to eradicate it, addiction to both legal and illicit
      drugs continues to be a major worldwide medical and social problem.
      Anti-addiction vaccines can produce the antibodies to block the effects of these 
      drugs on the brain, and have great potential to ameliorate the morbidity and
      mortality associated with illicit drug intoxications. This review provides a
      current overview of anti-addiction vaccines that are under clinical trial and
      pre-clinical research evaluation. It also outlines the development challenges,
      ethical concerns, and likely future intervention for anti-addiction vaccines.
FAU - Shen, Xiaoyun
AU  - Shen X
FAU - Orson, Frank M
AU  - Orson FM
FAU - Kosten, Thomas R
AU  - Kosten TR
LA  - eng
GR  - K05 DA000454/DA/NIDA NIH HHS/United States
GR  - P50 DA018197/DA/NIDA NIH HHS/United States
GR  - R01 DA026859/DA/NIDA NIH HHS/United States
GR  - R01 DA030338/DA/NIDA NIH HHS/United States
PT  - Journal Article
DEP - 20111003
PL  - England
TA  - F1000 Med Rep
JT  - F1000 medicine reports
JID - 101506841
PMC - PMC3186043
EDAT- 2011/10/18 06:00
MHDA- 2011/10/18 06:01
CRDT- 2011/10/18 06:00
PHST- 2011/10/18 06:00 [entrez]
PHST- 2011/10/18 06:00 [pubmed]
PHST- 2011/10/18 06:01 [medline]
AID - 10.3410/M3-20 [doi]
AID - 20 [pii]
PST - ppublish
SO  - F1000 Med Rep. 2011;3:20. doi: 10.3410/M3-20. Epub 2011 Oct 3.


PMID- 22002087
OWN - NLM
STAT- MEDLINE
DCOM- 20120312
LR  - 20220330
IS  - 1878-7479 (Electronic)
IS  - 1878-7479 (Linking)
VI  - 8
IP  - 4
DP  - 2011 Oct
TI  - Cellular treatments for spinal cord injury: the time is right for clinical
      trials.
PG  - 704-20
LID - 10.1007/s13311-011-0076-7 [doi]
AB  - More than 1 million people in the United States live with a spinal cord injury
      (SCI). Despite medical advances, many patients with SCIs still experience
      substantial neurological disability, with loss of motor, sensory, and autonomic
      function. Cell therapy is ideally suited to address the multifactorial nature of 
      the secondary events following SCI. Remarkable advances in our understanding of
      the pathophysiology of SCI, structural and functional magnetic resonance imaging,
      image-guided micro-neurosurgical techniques, and transplantable cell biology have
      enabled the use of cell-based regenerative techniques in the clinic. It is
      important to note that there are more than a dozen recently completed, ongoing,
      or recruiting cell therapy clinical trials for SCI that reflect the views of many
      key stakeholders. The field of regenerative neuroscience has reached a stage in
      which the clinical trials are scientifically and ethically justified. Although
      experimental models and analysis methods and techniques continue to evolve, no
      model will completely replicate the human condition. It is recognized that more
      work with cervical models of contusive/compressive SCI are required in parallel
      with clinical trials. It is also important that the clinical translation of
      advances made through well-established and validated experimental approaches in
      animal models move forward to meet the compelling needs of individuals with SCI
      and to advance the field of regenerative neuroscience. However, it is imperative 
      that such efforts at translation be done in the most rigorous and informed
      fashion to determine safety and possible efficacy, and to provide key information
      to clinicians and basic scientists, which will allow improvements in regenerative
      techniques and the validation and refinement of existing preclinical animal
      models and research approaches. The field of regenerative neuroscience should not
      be stalled at the animal model stage, but instead the clinical trials need to be 
      focused, safe, and ethical, backed up by a robust, translationally relevant
      preclinical research strategy.
FAU - Fehlings, Michael G
AU  - Fehlings MG
AD  - University Health Network, Toronto Western Hospital, Toronto, ON M5T2S8, Canada. 
      Michael.Fehlings@uhn.on.ca
FAU - Vawda, Reaz
AU  - Vawda R
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Neurotherapeutics
JT  - Neurotherapeutics : the journal of the American Society for Experimental
      NeuroTherapeutics
JID - 101290381
SB  - IM
MH  - Cell Transplantation/*methods
MH  - Clinical Trials as Topic/*methods/*trends
MH  - Humans
MH  - Spinal Cord Injuries/epidemiology/*surgery
PMC - PMC3210356
EDAT- 2011/10/18 06:00
MHDA- 2012/03/13 06:00
CRDT- 2011/10/18 06:00
PHST- 2011/10/18 06:00 [entrez]
PHST- 2011/10/18 06:00 [pubmed]
PHST- 2012/03/13 06:00 [medline]
AID - 10.1007/s13311-011-0076-7 [doi]
PST - ppublish
SO  - Neurotherapeutics. 2011 Oct;8(4):704-20. doi: 10.1007/s13311-011-0076-7.


PMID- 22000263
OWN - NLM
STAT- MEDLINE
DCOM- 20120628
LR  - 20120228
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 74
IP  - 6
DP  - 2012 Mar
TI  - Intangible obstacles: health implications of stigmatization, structural violence,
      and fear among undocumented immigrants in France.
PG  - 858-63
LID - 10.1016/j.socscimed.2011.08.016 [doi]
AB  - This study identifies undocumented immigrants' obstacles to realizing their
      health care rights in France. The ethnographic fieldwork informing this study was
      carried out in Paris from March 2007 to July 2008. Research findings are based on
      (1) participant observation carried out in two grassroots health associations
      catering to undocumented immigrants in Paris (one providing legal and medical aid
      to undocumented immigrants from sub-Saharan Africa, and another focused
      specifically on assisting undocumented individuals seeking a visa for medical
      reasons, as well as women victims of domestic violence); (2) a review of
      legislative debates on the issue of healthcare access for undocumented immigrants
      in France, and (3) recently published reports on healthcare access for the
      undocumented in Europe. The paper analyzes how interaction among intangible
      factors - namely social stigmatization, precarious living conditions, and the
      climate of fear and suspicion generated by increasingly restrictive immigration
      policies - hinders undocumented immigrants' access to health care rights and,
      furthermore, minimizes immigrants' sense of entitlement to such rights in this
      European context. Intangible factors such as fear and suspicion have powerful
      "subjectivation" effects, which influence how both undocumented immigrants and
      their interlocutors (i.e., healthcare providers) think about "deservingness."
      Medical anthropology is in a unique position to demonstrate and theorize these
      factors and effects, which inform contemporary debates about migration and
      "health ethics."
CI  - Copyright A(c) 2011 Elsevier Ltd. All rights reserved.
FAU - Larchanche, Stephanie
AU  - Larchanche S
AD  - IRIS-EHESS and Centre Francoise Minkowska, 12 rue Jacquemont, 75017 Paris,
      France. slarchan@go.wustl.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110921
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Anthropology, Cultural
MH  - France
MH  - Health Services Accessibility/economics/legislation & jurisprudence/*organization
      & administration
MH  - Health Status Disparities
MH  - Humans
MH  - *Policy
MH  - *Prejudice
MH  - Residence Characteristics
MH  - Sociology, Medical
MH  - Transients and Migrants/*legislation & jurisprudence/psychology/statistics &
      numerical data
MH  - *Violence
MH  - Women's Health
EDAT- 2011/10/18 06:00
MHDA- 2012/06/29 06:00
CRDT- 2011/10/18 06:00
PHST- 2010/11/16 00:00 [received]
PHST- 2011/08/09 00:00 [revised]
PHST- 2011/08/17 00:00 [accepted]
PHST- 2011/10/18 06:00 [entrez]
PHST- 2011/10/18 06:00 [pubmed]
PHST- 2012/06/29 06:00 [medline]
AID - S0277-9536(11)00523-5 [pii]
AID - 10.1016/j.socscimed.2011.08.016 [doi]
PST - ppublish
SO  - Soc Sci Med. 2012 Mar;74(6):858-63. doi: 10.1016/j.socscimed.2011.08.016. Epub
      2011 Sep 21.


PMID- 22000154
OWN - NLM
STAT- MEDLINE
DCOM- 20120327
LR  - 20181201
IS  - 1474-547X (Electronic)
IS  - 0140-6736 (Linking)
VI  - 379
IP  - 9820
DP  - 2012 Mar 17
TI  - Ethical disputes still beset Italian medicine 150 years after Count Cavour's
      death.
PG  - 1068-73
LID - 10.1016/S0140-6736(11)61382-2 [doi]
FAU - Remuzzi, Giuseppe
AU  - Remuzzi G
AD  - Negri Bergamo Laboratories, Mario Negri Institute for Pharmacological Research,
      Bergamo, Italy. giuseppe.remuzzi@marionegri.it
LA  - eng
PT  - Biography
PT  - Historical Article
PT  - Journal Article
PT  - Portrait
DEP - 20111013
PL  - England
TA  - Lancet
JT  - Lancet (London, England)
JID - 2985213R
SB  - IM
CIN - Lancet. 2012 Jul 14;380(9837):108; author reply 108-9. PMID: 22794240
CIN - Lancet. 2012 Jul 14;380(9837):108; author reply 108-9. PMID: 22794241
MH  - Bioethical Issues
MH  - Bloodletting/*history
MH  - *Famous Persons
MH  - History, 19th Century
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Italy
MH  - Reproductive Techniques, Assisted/legislation & jurisprudence
MH  - Research Support as Topic
MH  - Right to Die/legislation & jurisprudence
MH  - Stem Cell Research/legislation & jurisprudence
MH  - Terminal Care/legislation & jurisprudence
PS  - Count Cavour
FPS - Count Cavour
EDAT- 2011/10/18 06:00
MHDA- 2012/03/28 06:00
CRDT- 2011/10/18 06:00
PHST- 2011/10/18 06:00 [entrez]
PHST- 2011/10/18 06:00 [pubmed]
PHST- 2012/03/28 06:00 [medline]
AID - S0140-6736(11)61382-2 [pii]
AID - 10.1016/S0140-6736(11)61382-2 [doi]
PST - ppublish
SO  - Lancet. 2012 Mar 17;379(9820):1068-73. doi: 10.1016/S0140-6736(11)61382-2. Epub
      2011 Oct 13.


PMID- 22000137
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20220318
IS  - 1474-547X (Electronic)
IS  - 0140-6736 (Linking)
VI  - 378
IP  - 9800
DP  - 2011 Oct 15
TI  - A call for government accountability to achieve national self-sufficiency in
      organ donation and transplantation.
PG  - 1414-8
LID - 10.1016/S0140-6736(11)61486-4 [doi]
AB  - Roughly 100,000 patients worldwide undergo organ transplantation annually, but
      many other patients remain on waiting lists. Transplantation rates vary
      substantially across countries. Affluent patients in nations with long waiting
      lists do not always wait for donations from within their own countries.
      Commercially driven transplantation, however, does not always ensure proper
      medical care of recipients or donors, and might lengthen waiting times for
      resident patients or increase the illegal and unethical purchase of organs from
      living donors. Governments should systematically address the needs of their
      countries according to a legal framework. Medical strategies to prevent end-stage
      organ failure must also be implemented. In view of the Madrid Resolution, the
      Declaration of Istanbul, and the 63rd World Health Assembly Resolution, a new
      paradigm of national self-sufficiency is needed. Each country or region should
      strive to provide a sufficient number of organs from within its own population,
      guided by WHO ethics principles.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Delmonico, Francis L
AU  - Delmonico FL
AD  - New England Organ Bank, Waltham, MA 02451, USA. francis_delmonico@neob.org
FAU - Dominguez-Gil, Beatriz
AU  - Dominguez-Gil B
FAU - Matesanz, Rafael
AU  - Matesanz R
FAU - Noel, Luc
AU  - Noel L
LA  - eng
PT  - Journal Article
PL  - England
TA  - Lancet
JT  - Lancet (London, England)
JID - 2985213R
SB  - IM
MH  - *Government Agencies
MH  - Humans
MH  - International Cooperation
MH  - Living Donors/ethics/legislation & jurisprudence
MH  - Organ Transplantation/*legislation & jurisprudence
MH  - *Social Responsibility
MH  - Tissue and Organ Procurement/*legislation & jurisprudence
EDAT- 2011/10/18 06:00
MHDA- 2011/11/09 06:00
CRDT- 2011/10/18 06:00
PHST- 2011/10/18 06:00 [entrez]
PHST- 2011/10/18 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - S0140-6736(11)61486-4 [pii]
AID - 10.1016/S0140-6736(11)61486-4 [doi]
PST - ppublish
SO  - Lancet. 2011 Oct 15;378(9800):1414-8. doi: 10.1016/S0140-6736(11)61486-4.


PMID- 22000121
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20150616
IS  - 1474-547X (Electronic)
IS  - 0140-6736 (Linking)
VI  - 378
IP  - 9800
DP  - 2011 Oct 15
TI  - Ethics and organ transplantation.
PG  - 1356
LID - 10.1016/S0140-6736(11)61595-X [doi]
LA  - eng
PT  - Editorial
PL  - England
TA  - Lancet
JT  - Lancet (London, England)
JID - 2985213R
SB  - IM
MH  - Humans
MH  - Medical Tourism
MH  - Tissue and Organ Procurement/*ethics/legislation & jurisprudence
MH  - Transplants/*ethics
EDAT- 2011/10/18 06:00
MHDA- 2011/11/09 06:00
CRDT- 2011/10/18 06:00
PHST- 2011/10/18 06:00 [entrez]
PHST- 2011/10/18 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - S0140-6736(11)61595-X [pii]
AID - 10.1016/S0140-6736(11)61595-X [doi]
PST - ppublish
SO  - Lancet. 2011 Oct 15;378(9800):1356. doi: 10.1016/S0140-6736(11)61595-X.


PMID- 21999786
OWN - NLM
STAT- MEDLINE
DCOM- 20120228
LR  - 20111017
IS  - 1943-569X (Electronic)
IS  - 0003-1488 (Linking)
VI  - 239
IP  - 9
DP  - 2011 Nov 1
TI  - Learning under the influence: vet schools developing ethics policies to avoid
      conflicts of interest.
PG  - 1150-4
LID - 10.2460/javma.239.9.1150 [doi]
FAU - Larkin, Malinda
AU  - Larkin M
LA  - eng
PT  - News
PL  - United States
TA  - J Am Vet Med Assoc
JT  - Journal of the American Veterinary Medical Association
JID - 7503067
SB  - IM
CIN - J Am Vet Med Assoc. 2011 Dec 15;239(12):1544. PMID: 22129115
MH  - Codes of Ethics/*trends
MH  - *Conflict of Interest
MH  - Faculty
MH  - *Organizational Policy
MH  - Research Support as Topic
MH  - Schools, Veterinary/*ethics
MH  - Students
MH  - Veterinary Medicine/ethics/organization & administration
EDAT- 2011/10/18 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/10/18 06:00
PHST- 2011/10/18 06:00 [entrez]
PHST- 2011/10/18 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - 10.2460/javma.239.9.1150 [doi]
PST - ppublish
SO  - J Am Vet Med Assoc. 2011 Nov 1;239(9):1150-4. doi: 10.2460/javma.239.9.1150.


PMID- 21999623
OWN - NLM
STAT- MEDLINE
DCOM- 20120123
LR  - 20220317
IS  - 1745-3682 (Electronic)
IS  - 1745-3674 (Linking)
VI  - 82
IP  - 6
DP  - 2011 Dec
TI  - Reduction of blood loss in primary hip arthroplasty with tranexamic acid or
      fibrin spray.
PG  - 660-3
LID - 10.3109/17453674.2011.623568 [doi]
AB  - BACKGROUND AND PURPOSE: Previous studies have shown that either fibrin spray or
      tranexamic acid can reduce blood loss at total hip replacement, but the 2
      treatments have not been directly compared. We therefore conducted a randomized, 
      controlled trial. PATIENTS AND METHODS: In this randomized controlled trial we
      compared the effect of tranexamic acid and fibrin spray on blood loss in cemented
      total hip arthroplasty. 66 patients were randomized to 1 of 3 parallel groups
      receiving (1) a 10 mg/kg bolus of tranexamic acid prior to surgery, (2) 10 mL of 
      fibrin spray during surgery, or (3) neither. All participants except the surgeon 
      were blinded as to treatment group until data analysis was complete. Blood loss
      was calculated from preoperative and postoperative hematocrit. RESULTS: Neither
      active treatment was found to be superior to the other in terms of overall blood 
      loss. Losses were lower than those in the control group, when using either
      tranexamic acid (22% lower, p = 0.02) or fibrin spray (32% lower, p = 0.02).
      INTERPRETATION: We found that the use of tranexamic acid at induction, or topical
      fibrin spray intraoperatively, reduced blood loss compared to the control group. 
      Blood loss was similar in the fibrin spray group and in the tranexamic acid
      group. ClinicalTrials.gov identifier: NCT00378872. EudraCT identifier:
      2006-001299-19. Regional Ethics Committee approval: 06/S0703/55, granted June 6, 
      2006.
FAU - McConnell, Jamie S
AU  - McConnell JS
AD  - Royal National Orthopaedic Hospital, Stanmore, Middlesex, UK. jsm@doctors.net.uk
FAU - Shewale, Sandeep
AU  - Shewale S
FAU - Munro, Niall A
AU  - Munro NA
FAU - Shah, Kalpesh
AU  - Shah K
FAU - Deakin, Angela H
AU  - Deakin AH
FAU - Kinninmonth, Andrew W G
AU  - Kinninmonth AW
LA  - eng
SI  - ClinicalTrials.gov/NCT00378872
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20111017
PL  - Sweden
TA  - Acta Orthop
JT  - Acta orthopaedica
JID - 101231512
RN  - 0 (Antifibrinolytic Agents)
RN  - 0 (Fibrin Tissue Adhesive)
RN  - 0 (Hemostatics)
RN  - 6T84R30KC1 (Tranexamic Acid)
SB  - IM
MH  - Administration, Topical
MH  - Adult
MH  - Antifibrinolytic Agents/*administration & dosage
MH  - *Arthroplasty, Replacement, Hip/adverse effects/methods
MH  - *Blood Loss, Surgical/prevention & control
MH  - Female
MH  - Fibrin Tissue Adhesive/*administration & dosage
MH  - Hematocrit
MH  - Hemostatics/*administration & dosage
MH  - Humans
MH  - Male
MH  - Prospective Studies
MH  - Single-Blind Method
MH  - Tranexamic Acid/*administration & dosage
MH  - Treatment Outcome
PMC - PMC3247881
EDAT- 2011/10/18 06:00
MHDA- 2012/01/24 06:00
CRDT- 2011/10/18 06:00
PHST- 2011/10/18 06:00 [entrez]
PHST- 2011/10/18 06:00 [pubmed]
PHST- 2012/01/24 06:00 [medline]
AID - 10.3109/17453674.2011.623568 [doi]
PST - ppublish
SO  - Acta Orthop. 2011 Dec;82(6):660-3. doi: 10.3109/17453674.2011.623568. Epub 2011
      Oct 17.


PMID- 21999082
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20190923
IS  - 0743-2550 (Print)
IS  - 0743-2550 (Linking)
VI  - 28
IP  - 4
DP  - 2011 Oct-Dec
TI  - Spiritual care: evangelism at the bedside.
PG  - 194-202; quiz 203-4
AB  - News media stories about Christian nurses sharing religious beliefs with patients
      raise questions about ethical spiritual care and the appropriateness of sharing
      one's faith at the bedside. The purpose of this article is to explore the ethics 
      of faith sharing in the context of Christian nursing and offer guidance for
      ethical spiritual care.
FAU - Taylor, Elizabeth Johnston
AU  - Taylor EJ
AD  - Loma Linda University School of Nursing, Loma Linda, CA, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Christ Nurs
JT  - Journal of Christian nursing : a quarterly publication of Nurses Christian
      Fellowship
JID - 8411743
MH  - *Christianity
MH  - Education, Nursing, Continuing
MH  - Faith Healing/*ethics/standards
MH  - Holistic Nursing/*ethics/standards
MH  - Humans
MH  - Nursing Staff/*ethics/standards
MH  - Practice Guidelines as Topic
EDAT- 2011/10/18 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/10/18 06:00
PHST- 2011/10/18 06:00 [entrez]
PHST- 2011/10/18 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - 10.1097/cnj.0b013e31822b494d [doi]
PST - ppublish
SO  - J Christ Nurs. 2011 Oct-Dec;28(4):194-202; quiz 203-4. doi:
      10.1097/cnj.0b013e31822b494d.


PMID- 21999017
OWN - NLM
STAT- MEDLINE
DCOM- 20111220
LR  - 20131105
IS  - 0949-2739 (Print)
IS  - 0949-2739 (Linking)
VI  - 27
DP  - 2011
TI  - [Indirect euthanasia from the ethical viewpoint].
PG  - 117-68
LA  - ger
PT  - Journal Article
TT  - Die indirekte Sterbehilfe aus ethischer Sicht.
PL  - Germany
TA  - Neuere Med Wiss Quellen Stud
JT  - Neuere Medizin- und Wissenschaftsgeschichte
JID - 9605423
RN  - 0 (Analgesics, Opioid)
MH  - Analgesics, Opioid/administration & dosage/*toxicity
MH  - Attitude of Health Personnel
MH  - Double Effect Principle
MH  - *Ethics, Medical
MH  - Euthanasia/*ethics/legislation & jurisprudence
MH  - Euthanasia, Active/ethics/legislation & jurisprudence
MH  - Euthanasia, Passive/ethics/legislation & jurisprudence
MH  - Germany
MH  - Humans
MH  - Intention
MH  - Morals
MH  - Pain, Intractable/*drug therapy
MH  - Physician's Role
MH  - Terminal Care/*ethics/legislation & jurisprudence
EDAT- 2011/10/18 06:00
MHDA- 2011/12/21 06:00
CRDT- 2011/10/18 06:00
PHST- 2011/10/18 06:00 [entrez]
PHST- 2011/10/18 06:00 [pubmed]
PHST- 2011/12/21 06:00 [medline]
PST - ppublish
SO  - Neuere Med Wiss Quellen Stud. 2011;27:117-68.


PMID- 21998237
OWN - NLM
STAT- MEDLINE
DCOM- 20120214
LR  - 20211020
IS  - 1715-5258 (Electronic)
IS  - 0008-350X (Linking)
VI  - 57
IP  - 10
DP  - 2011 Oct
TI  - Ethics and privacy issues of a practice-based surveillance system: need for a
      national-level institutional research ethics board and consent standards.
PG  - 1165-73
AB  - OBJECTIVE: To describe the challenges the Canadian Primary Care Sentinel
      Surveillance Network (CPCSSN) experienced with institutional research ethics
      boards (IREBs) when seeking approvals across jurisdictions and to provide
      recommendations for overcoming challenges of ethical review for multisite and
      multijurisdictional surveillance and research. BACKGROUND: The CPCSSN project
      collects and validates longitudinal primary care health information (relating to 
      hypertension, diabetes, depression, chronic obstructive lung disease, and
      osteoarthritis) from electronic medical records across Canada. Privacy and data
      storage security policies and processes have been developed to protect
      participants' privacy and confidentiality, and IREB approval is obtained in each 
      participating jurisdiction. Inconsistent interpretation and application of
      privacy and ethical issues by IREBs delays and impedes research programs that
      could better inform us about chronic disease. RESULTS: The CPCSSN project's
      experience with gaining approval from IREBs highlights the difficulty of
      conducting pan-Canadian health surveillance and multicentre research.
      Inconsistent IREB approvals to waive explicit individual informed consent
      produced particular challenges for researchers. CONCLUSION: The CPCSSN experience
      highlights the need to develop a better process for researchers to obtain timely 
      and consistent IREB approvals for multicentre surveillance and research. We
      suggest developing a specialized, national, centralized IREB responsible for
      approving multisite studies related to population health research.
FAU - Kotecha, Jyoti A
AU  - Kotecha JA
AD  - Department of Family Medicine, Queen's University, Kingston, ON, Canada.
      jyoti.kotecha@queensu.ca
FAU - Manca, Donna
AU  - Manca D
FAU - Lambert-Lanning, Anita
AU  - Lambert-Lanning A
FAU - Keshavjee, Karim
AU  - Keshavjee K
FAU - Drummond, Neil
AU  - Drummond N
FAU - Godwin, Marshall
AU  - Godwin M
FAU - Greiver, Michelle
AU  - Greiver M
FAU - Putnam, Wayne
AU  - Putnam W
FAU - Lussier, Marie-Therese
AU  - Lussier MT
FAU - Birtwhistle, Richard
AU  - Birtwhistle R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - Canada
TA  - Can Fam Physician
JT  - Canadian family physician Medecin de famille canadien
JID - 0120300
SB  - IM
CIN - Can Fam Physician. 2011 Oct;57(10):1113-4. PMID: 21998218
CIN - Can Fam Physician. 2012 Feb;58(2):153-5; author reply 155-6. PMID: 22337737
MH  - Biomedical Research/*ethics
MH  - Canada
MH  - Family Practice/*ethics
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Primary Health Care/*ethics
MH  - Program Development/*methods
MH  - *Surveys and Questionnaires
PMC - PMC3192088
EDAT- 2011/10/15 06:00
MHDA- 2012/02/15 06:00
CRDT- 2011/10/15 06:00
PHST- 2011/10/15 06:00 [entrez]
PHST- 2011/10/15 06:00 [pubmed]
PHST- 2012/02/15 06:00 [medline]
AID - 57/10/1165 [pii]
PST - ppublish
SO  - Can Fam Physician. 2011 Oct;57(10):1165-73.


PMID- 21998047
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20220408
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 261
IP  - 3
DP  - 2011 Dec
TI  - Imaging study of early hepatocellular carcinoma: usefulness of gadoxetic
      acid-enhanced MR imaging.
PG  - 834-44
LID - 10.1148/radiol.11101840 [doi]
AB  - PURPOSE: To describe imaging findings of early hepatocellular carcinoma (HCC) at 
      gadoxetic acid-enhanced magnetic resonance (MR) imaging, dynamic contrast
      material-enhanced computed tomography (CT), CT during arterial portography
      (CTAP), and CT during hepatic arteriography (CTHA) and to compare the diagnostic 
      performance of each modality for small (</= 2 cm) HCC. MATERIALS AND METHODS: The
      institute ethics committee deemed study approval unnecessary. One hundred eight
      resected small lesions in 64 patients were diagnosed as a dysplastic nodule (DN) 
      (n = 12), progressed HCC (n = 66), or early HCC (n = 30). All but two patients
      underwent all imaging examinations. The imaging characteristics of the lesions
      with each modality were determined. To evaluate the diagnostic performance of the
      modalities, two radiologists graded the presence of HCC with use of a five-point 
      confidence scale. The area under the receiver operating characteristic curve
      (A(z)), sensitivity, and specificity of each modality were compared. RESULTS: The
      imaging features that are statistically significant for differentiating an early 
      HCC from a DN include fat-containing lesions at dual-echo T1-weighted MR imaging 
      (seen in 16 of the 30 early HCCs and none of the DNs), low attenuation at
      unenhanced CT (seen in 13 of the 30 early HCCs and none of the DNs), low
      attenuation at CTAP (seen in 11 of the 30 early HCCs and none of the DNs), and
      low signal intensity at hepatocyte phase gadoxetic acid-enhanced MR imaging (seen
      in 29 of the 30 early HCCs and none of the DNs). The diagnostic performance of
      gadoxetic acid-enhanced MR imaging (A(z), 0.98 and 0.99) was significantly
      greater than that of contrast-enhanced CT (A(z), 0.87) and CTHA-CTAP (A(z), 0.85 
      and 0.86) owing to its significantly higher sensitivity (P < .001). CONCLUSION:
      Gadoxetic acid-enhanced MR imaging is the most useful imaging technique for
      evaluating small HCC, including early HCC.
CI  - (c) RSNA, 2011.
FAU - Sano, Katsuhiro
AU  - Sano K
AD  - Department of Radiology, University of Yamanashi, 1110 Shimokato, Chuo-shi,
      Yamanashi 409-3898, Japan.
FAU - Ichikawa, Tomoaki
AU  - Ichikawa T
FAU - Motosugi, Utaroh
AU  - Motosugi U
FAU - Sou, Hironobu
AU  - Sou H
FAU - Muhi, Ali M
AU  - Muhi AM
FAU - Matsuda, Masanori
AU  - Matsuda M
FAU - Nakano, Masayuki
AU  - Nakano M
FAU - Sakamoto, Michiie
AU  - Sakamoto M
FAU - Nakazawa, Tadao
AU  - Nakazawa T
FAU - Asakawa, Masami
AU  - Asakawa M
FAU - Fujii, Hideki
AU  - Fujii H
FAU - Kitamura, Takatoshi
AU  - Kitamura T
FAU - Enomoto, Nobuyuki
AU  - Enomoto N
FAU - Araki, Tsutomu
AU  - Araki T
LA  - eng
PT  - Journal Article
DEP - 20111013
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - 0 (gadolinium ethoxybenzyl DTPA)
RN  - 4419T9MX03 (Iohexol)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Aged
MH  - Carcinoma, Hepatocellular/*diagnosis/diagnostic imaging/pathology
MH  - Chi-Square Distribution
MH  - *Contrast Media
MH  - Early Diagnosis
MH  - Female
MH  - *Gadolinium DTPA
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Iohexol
MH  - Liver Neoplasms/*diagnosis/diagnostic imaging/pathology
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - ROC Curve
MH  - Sensitivity and Specificity
MH  - Tomography, X-Ray Computed/methods
EDAT- 2011/10/15 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/10/15 06:00
PHST- 2011/10/15 06:00 [entrez]
PHST- 2011/10/15 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - radiol.11101840 [pii]
AID - 10.1148/radiol.11101840 [doi]
PST - ppublish
SO  - Radiology. 2011 Dec;261(3):834-44. doi: 10.1148/radiol.11101840. Epub 2011 Oct
      13.


PMID- 21997743
OWN - NLM
STAT- MEDLINE
DCOM- 20150326
LR  - 20111014
IS  - 0095-4829 (Print)
IS  - 0095-4829 (Linking)
IP  - 37
DP  - 2011
TI  - Myelomeningocele (open spina bifida) - surgical management.
PG  - 113-41
LID - 10.1007/978-3-7091-0673-0_5 [doi]
AB  - Myelomeningocele has been recognized since ancient times although written
      descriptions began not before the 17th century. Among all serious congenital
      malformations, myelomeningocele is unique that is has a steady and considerable
      prevalence while being compatible with life. It has a dismal prognosis when left 
      untreated where virtually all die within the first year while aggressive
      treatment have a profound effect on survival and quality of life. Effective
      surgical treatment became possible parallel to the treatment of hydrocephalus in 
      the late 1950s. Advent of the shunt systems undoubtedly changed the morbidity and
      mortality rates due to associated hydrocephalus. Aggressive and effective
      treatment improved survival rates but also those suffering physical and mental
      disabilities have increased as well. Ethical and socioeconomic concerns have led 
      to proposal for selective treatment criteria which have raised arguments on
      medical and ethico-legal rounds. After the swing of the pendulum between early
      treatment in all affected children and selective treatment of those who fulfilled
      the criteria for good prognosis, early myelomeningocele repair is practiced
      widely unless the infant is critically ill.Incidence of myelomeningocele has been
      decreasing especially in the Western world, partly due to prenatal diagnosis and 
      elective terminations, dietary folate supplementation. Still, it is the most
      common central nervous system malformation and one of the leading causes of
      paraplegia, worldwide. Unfortunately, gains in the management of myelomeningocele
      have been mainly on antenatal diagnosis and prevention while efforts on
      understanding its cause, mechanisms involved are still tentative. Concerning the 
      surgical management, no revolutionary modification improving outcome has been
      introduced unlike other fields of neurosurgery.Medical management of a child with
      myelomeningocele requires a lifelong effort of several disciplines including
      urology, orthopedics physical and social therapy besides neurosurgery. The
      initial and probably the most crucial step begin with proper repair of the
      lesion. The aim of surgery, with its simplest definition should be towards
      maintaining the medical condition of the newborn. In other words, consequences of
      an open spinal cord segment with associated malformations have to be avoided with
      appropriate measures. Comparable to the surgical treatment of any congenital
      malformation, myelomeningocele repair consist of reversing the failed steps of
      normal neural tube closure. This requires a thorough understanding of the normal 
      and abnormal embryological sequence of events in formation of the spinal cord.
      Although the purpose of this chapter is to describe the basic concepts and
      technique of myelomeningocele repair, contemporary information and progress on
      epidemiology, and etiology and embryology is presented with discussion of
      controversial issues regarding the selection process, optimal time for surgery
      and technical modifications.
FAU - Akalan, N
AU  - Akalan N
AD  - Department of Neurosurgery, Hacettepe University School of Medicine, Ankara,
      Turkey.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Adv Tech Stand Neurosurg
JT  - Advances and technical standards in neurosurgery
JID - 7501064
SB  - IM
MH  - Fetal Diseases/diagnosis/epidemiology/*surgery
MH  - Humans
MH  - Infant, Newborn
MH  - Meningomyelocele/diagnosis/epidemiology/*surgery
MH  - Neurosurgical Procedures/*methods
MH  - Prenatal Diagnosis
MH  - Spina Bifida Cystica/diagnosis/epidemiology/*surgery
EDAT- 2011/10/15 06:00
MHDA- 2015/03/27 06:00
CRDT- 2011/10/15 06:00
PHST- 2011/10/15 06:00 [entrez]
PHST- 2011/10/15 06:00 [pubmed]
PHST- 2015/03/27 06:00 [medline]
AID - 10.1007/978-3-7091-0673-0_5 [doi]
PST - ppublish
SO  - Adv Tech Stand Neurosurg. 2011;(37):113-41. doi: 10.1007/978-3-7091-0673-0_5.


PMID- 21997673
OWN - NLM
STAT- MEDLINE
DCOM- 20120119
LR  - 20220311
IS  - 1468-201X (Electronic)
IS  - 1355-6037 (Linking)
VI  - 97
IP  - 24
DP  - 2011 Dec
TI  - The ethics of pacemaker reuse: might the best be the enemy of the good?
PG  - 2005-6
LID - 10.1136/heartjnl-2011-301031 [doi]
FAU - Aragam, Krishna G
AU  - Aragam KG
AD  - Division of Cardiovascular Medicine, University of Pennsylvania, Philadelphia,
      Pennsylvania, USA.
FAU - Baman, Timir S
AU  - Baman TS
FAU - Kirkpatrick, James N
AU  - Kirkpatrick JN
FAU - Goldman, Edward B
AU  - Goldman EB
FAU - Brown, Archie C
AU  - Brown AC
FAU - Crawford, Thomas
AU  - Crawford T
FAU - Oral, Hakan
AU  - Oral H
FAU - Eagle, Kim A
AU  - Eagle KA
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111013
PL  - England
TA  - Heart
JT  - Heart (British Cardiac Society)
JID - 9602087
SB  - IM
MH  - Bradycardia/*therapy
MH  - Equipment Contamination/*prevention & control/statistics & numerical data
MH  - Equipment Reuse
MH  - *Ethics, Medical
MH  - Humans
MH  - Pacemaker, Artificial/ethics/*statistics & numerical data
MH  - Sterilization
EDAT- 2011/10/15 06:00
MHDA- 2012/01/20 06:00
CRDT- 2011/10/15 06:00
PHST- 2011/10/15 06:00 [entrez]
PHST- 2011/10/15 06:00 [pubmed]
PHST- 2012/01/20 06:00 [medline]
AID - heartjnl-2011-301031 [pii]
AID - 10.1136/heartjnl-2011-301031 [doi]
PST - ppublish
SO  - Heart. 2011 Dec;97(24):2005-6. doi: 10.1136/heartjnl-2011-301031. Epub 2011 Oct
      13.


PMID- 21997582
OWN - NLM
STAT- MEDLINE
DCOM- 20111202
LR  - 20111014
IS  - 0030-6002 (Print)
IS  - 0030-6002 (Linking)
VI  - 152
IP  - 44
DP  - 2011 Oct 30
TI  - [Lung transplantation in Hungary (1996-2011)].
PG  - 1772-4
LID - 10.1556/OH.2011.29229 [doi]
AB  - The 15 years history of lung transplantation in Hungary shows the medical,
      political and social characteristics of this period. The barely determined,
      open-ended legal, financial and ethical framework of transplantation has stayed
      nowadays in the same position. The Hungarian State Audit Office has also noted
      these problems. Joining of Hungary to Eurotransplant will beneficially influence 
      the whole procedure.
FAU - Strausz, Janos
AU  - Strausz J
AD  - Orszagos Koranyi Tbc es Pulmonologiai Intezet Budapest. strausz@koranyi.hu
LA  - hun
PT  - English Abstract
PT  - Journal Article
TT  - Tudotranszplantacio Magyarorszagon (1996-2011).
PL  - Hungary
TA  - Orv Hetil
JT  - Orvosi hetilap
JID - 0376412
SB  - IM
MH  - Austria
MH  - European Union
MH  - Humans
MH  - Hungary
MH  - *Lung Transplantation/economics/legislation & jurisprudence/statistics &
      numerical data
MH  - Medical Audit
MH  - Medical Tourism
MH  - Politics
MH  - Tissue and Organ Procurement/ethics/legislation & jurisprudence/statistics &
      numerical data/trends
MH  - *Waiting Lists
EDAT- 2011/10/15 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/10/15 06:00
PHST- 2011/10/15 06:00 [entrez]
PHST- 2011/10/15 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - N844844W37711256 [pii]
AID - 10.1556/OH.2011.29229 [doi]
PST - ppublish
SO  - Orv Hetil. 2011 Oct 30;152(44):1772-4. doi: 10.1556/OH.2011.29229.


PMID- 21997549
OWN - NLM
STAT- MEDLINE
DCOM- 20120727
LR  - 20130214
IS  - 1468-3288 (Electronic)
IS  - 0017-5749 (Linking)
VI  - 61
IP  - 5
DP  - 2012 May
TI  - Role of biological therapy for inflammatory bowel disease in developing
      countries.
PG  - 706-12
LID - 10.1136/gutjnl-2011-300613 [doi]
AB  - Inflammatory bowel disease (IBD) has become a global disease. Its incidence in
      developing countries is rising. In Asia, this has been attributed to the rapid
      modernisation and westernisation of the population. As IBD emerges in developing 
      nations, there is a need to reconcile the most appropriate treatment for these
      patient populations from the perspectives of both disease presentation and cost. 
      In the West, biological agents are the fastest-growing segment of the
      prescription drug market. They typically cost several thousand to several tens of
      thousands of dollars per patient per year. The healthcare systems in developing
      countries will struggle to afford such expensive treatments. Developing countries
      cover two-thirds of the earth's surface and are home to 3-5 billion inhabitants, 
      constituting three-quarters of all humanity. If IBD emerges to the same extent in
      those countries as it has in the West, the need for biological therapy will
      increase dramatically, and the pharmaceutical industry, healthcare providers,
      patient advocate groups, governments and non-governmental organisations will have
      to discuss how to handle this. The authors propose that this dialogue should
      begin now with regard to (1) the major needs of patients with complicated IBD in 
      developing countries, (2) the potential need for biological therapy in developing
      countries to treat IBD, (3) the necessary infrastructure for selecting patients
      with IBD who need biological therapy, and (4) medical/ethical issues limiting the
      use of biological therapy.
FAU - Rogler, Gerhard
AU  - Rogler G
AD  - Division of Gastroenterology and Hepatology, Department of Internal Medicine,
      University-Hospital of Zurich, Zurich, Switzerland. gerhard.rogler@usz.ch
FAU - Bernstein, Charles N
AU  - Bernstein CN
FAU - Sood, Ajit
AU  - Sood A
FAU - Goh, Khean Lee
AU  - Goh KL
FAU - Yamamoto-Furusho, Jesus K
AU  - Yamamoto-Furusho JK
FAU - Abbas, Zaigham
AU  - Abbas Z
FAU - Fried, Michael
AU  - Fried M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111013
PL  - England
TA  - Gut
JT  - Gut
JID - 2985108R
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antibodies, Monoclonal)
SB  - IM
CIN - Gut. 2013 Feb;62(2):334. PMID: 22942240
MH  - Anti-Inflammatory Agents/economics/*therapeutic use
MH  - Antibodies, Monoclonal/economics/*therapeutic use
MH  - *Biological Therapy/economics/ethics
MH  - *Developing Countries
MH  - Drug Costs
MH  - *Health Services Accessibility/ethics
MH  - Humans
MH  - Inflammatory Bowel Diseases/*drug therapy/economics/epidemiology
MH  - Practice Guidelines as Topic
EDAT- 2011/10/15 06:00
MHDA- 2012/07/28 06:00
CRDT- 2011/10/15 06:00
PHST- 2011/10/15 06:00 [entrez]
PHST- 2011/10/15 06:00 [pubmed]
PHST- 2012/07/28 06:00 [medline]
AID - gutjnl-2011-300613 [pii]
AID - 10.1136/gutjnl-2011-300613 [doi]
PST - ppublish
SO  - Gut. 2012 May;61(5):706-12. doi: 10.1136/gutjnl-2011-300613. Epub 2011 Oct 13.


PMID- 21997514
OWN - NLM
STAT- MEDLINE
DCOM- 20120619
LR  - 20211020
IS  - 1432-1998 (Electronic)
IS  - 0301-0449 (Linking)
VI  - 42
IP  - 2
DP  - 2012 Feb
TI  - Ethics and teamwork for pediatric medical imaging procedures: insights from
      educational play therapy.
PG  - 139-46
LID - 10.1007/s00247-011-2271-4 [doi]
FAU - Delany, Clare
AU  - Delany C
AD  - The Children's Bioethics Centre, The Royal Children's Hospital Melbourne, 50
      Flemington Road, Melbourne, Australia. c.delany@unimelb.edu.au
FAU - Conwell, Melati
AU  - Conwell M
LA  - eng
PT  - Journal Article
DEP - 20111014
PL  - Germany
TA  - Pediatr Radiol
JT  - Pediatric radiology
JID - 0365332
SB  - IM
MH  - Australia
MH  - Decision Making
MH  - Diagnostic Imaging/*ethics
MH  - Documentation
MH  - Evidence-Based Medicine
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Interviews as Topic
MH  - *Patient Care Team
MH  - Pediatrics/*ethics
MH  - *Play Therapy
EDAT- 2011/10/15 06:00
MHDA- 2012/06/20 06:00
CRDT- 2011/10/15 06:00
PHST- 2011/05/30 00:00 [received]
PHST- 2011/09/01 00:00 [accepted]
PHST- 2011/09/01 00:00 [revised]
PHST- 2011/10/15 06:00 [entrez]
PHST- 2011/10/15 06:00 [pubmed]
PHST- 2012/06/20 06:00 [medline]
AID - 10.1007/s00247-011-2271-4 [doi]
PST - ppublish
SO  - Pediatr Radiol. 2012 Feb;42(2):139-46. doi: 10.1007/s00247-011-2271-4. Epub 2011 
      Oct 14.


PMID- 21997164
OWN - NLM
STAT- MEDLINE
DCOM- 20120402
LR  - 20220129
IS  - 1439-1104 (Electronic)
IS  - 1354-2516 (Linking)
VI  - 11
IP  - 2
DP  - 2011 Dec
TI  - Teaching report: the use of Drosophila melanogaster larval thermosensitive escape
      behaviour as a model system to demonstrate sensory function.
PG  - 109-12
LID - 10.1007/s10158-011-0123-4 [doi]
AB  - We describe how a novel thermosensitive escape behaviour in Drosophila larvae can
      be used to teach neurobiology principles to both undergraduates and school
      children. The assays are inexpensive, robust and reliably accurate employing
      apparatus readily available in most science classrooms. The use of Drosophila
      avoids the employment of vertebrate models and the ethical and expense issues
      that this entails. We use this practical to effectively teach the principals of
      calibration and neural sensory responses to post-16-year-old students and
      undergraduate students.
FAU - Harrison, Adrian B
AU  - Harrison AB
AD  - Department of Biology (Area 1), University of York, P.O. Box 373, York YO10 5YW, 
      UK. adrian.harrison@york.ac.uk
FAU - Oswald, Matthew
AU  - Oswald M
FAU - Sweeney, Sean T
AU  - Sweeney ST
LA  - eng
GR  - G0400580/MRC_/Medical Research Council/United Kingdom
GR  - BB_/Biotechnology and Biological Sciences Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111014
PL  - Germany
TA  - Invert Neurosci
JT  - Invertebrate neuroscience : IN
JID - 9602489
SB  - IM
MH  - Adolescent
MH  - Animals
MH  - Bioethical Issues
MH  - Calibration
MH  - Drosophila melanogaster/physiology
MH  - Humans
MH  - Laboratories
MH  - Larva/physiology
MH  - Models, Animal
MH  - Nociception/*physiology
MH  - Peripheral Nervous System/*physiology
MH  - Research/*education
MH  - Sensation/*physiology
MH  - Students
MH  - Teaching/*methods
MH  - Young Adult
EDAT- 2011/10/15 06:00
MHDA- 2012/04/03 06:00
CRDT- 2011/10/15 06:00
PHST- 2011/09/20 00:00 [received]
PHST- 2011/09/29 00:00 [accepted]
PHST- 2011/10/15 06:00 [entrez]
PHST- 2011/10/15 06:00 [pubmed]
PHST- 2012/04/03 06:00 [medline]
AID - 10.1007/s10158-011-0123-4 [doi]
PST - ppublish
SO  - Invert Neurosci. 2011 Dec;11(2):109-12. doi: 10.1007/s10158-011-0123-4. Epub 2011
      Oct 14.


PMID- 21996704
OWN - NLM
STAT- MEDLINE
DCOM- 20120116
LR  - 20111014
IS  - 1423-0356 (Electronic)
IS  - 0025-7931 (Linking)
VI  - 82
IP  - 5
DP  - 2011
TI  - Can help for patients be too expensive? Ethical considerations and end-stage lung
      disease.
PG  - 395-9
LID - 10.1159/000332232 [doi]
AB  - The treatment of patients with end-stage lung disease is very expensive. In an
      era of cost containment, the physician could be forced to restrict his therapy in
      order to spend less. But does the physician really have the right to restrict a
      reasonable therapy for economic reasons? It is argued that the mission of
      medicine is to help people in need and that any confidence is shaken if the
      physician is forced to be both physician and gatekeeper at the same time. It is
      argued that medicine as a central form of care will only be able to survive if it
      has the chance to remain a free profession, a profession which has the liberty to
      help each individual patient even if this help is expensive. However, it remains 
      a duty of the physician to accept limits and to learn that for a good death it is
      necessary to be honest and to talk early enough about the possibilities of
      palliative care.
CI  - Copyright (c) 2011 S. Karger AG, Basel.
FAU - Maio, Giovanni
AU  - Maio G
AD  - Institute for Medical Ethics and History of Medicine, University of Freiburg,
      Freiburg i.Br., Germany. maio@ethik.uni-freiburg.de
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111013
PL  - Switzerland
TA  - Respiration
JT  - Respiration; international review of thoracic diseases
JID - 0137356
SB  - IM
MH  - Cost-Benefit Analysis
MH  - Decision Making/*ethics
MH  - Ethics, Medical
MH  - Female
MH  - Humans
MH  - Lung Diseases/economics/mortality/*therapy
MH  - Male
MH  - Palliative Care/economics/*ethics
MH  - *Physician's Role
MH  - *Physician-Patient Relations
EDAT- 2011/10/15 06:00
MHDA- 2012/01/17 06:00
CRDT- 2011/10/15 06:00
PHST- 2011/10/15 06:00 [entrez]
PHST- 2011/10/15 06:00 [pubmed]
PHST- 2012/01/17 06:00 [medline]
AID - 000332232 [pii]
AID - 10.1159/000332232 [doi]
PST - ppublish
SO  - Respiration. 2011;82(5):395-9. doi: 10.1159/000332232. Epub 2011 Oct 13.


PMID- 21996637
OWN - NLM
STAT- MEDLINE
DCOM- 20120229
LR  - 20190902
IS  - 0300-9173 (Print)
IS  - 0300-9173 (Linking)
VI  - 48
IP  - 4
DP  - 2011
TI  - [Electroencephalographic examination of the cerebral activity of elderly people
      living in a nursing home after postural change from supine to sitting positions].
PG  - 378-90
AB  - AIM: We investigated the cerebral activity of elderly persons living in a nursing
      home in the sitting position by analyzing the electroencephalography findings of 
      postural changes in the supine and sitting positions. METHODS: This study was
      approved by the Health Ethics Committee of Osaka University. The subjects were 17
      elderly people (4 men and 13 women, average age 85.35 +/- 8.26 years) living in a
      nursing home. Electroencephalograms were obtained in 8 cerebral regions (the left
      front-polar (Fp(1)); right front-polar (Fp(2)); left frontal (F(3)); right
      frontal (F(4)); left central (C(3)); right central (C(4)); left occipital (O(1)) 
      and right occipital (O(2))) while subjects sat in a head-up position in bed, or
      in a chair or wheelchair. Measurement was obtained over 5-minute supine,
      15-minute sitting, and 5-minute conversation periods. We performed the fast
      Fourier transform on measured electroencephalograms to calculate the average
      power values of alpha band components (8-13 Hz) and beta band components (13-30
      Hz) for each cerebral section. RESULTS: Compared with the supine position, the
      sitting position in bed did not show a significant increase in power values,
      whereas the sitting position in a chair showed significant increases in power
      values in all regions. Most of the time, the findings of patients sitting
      position in a chair showed significantly higher power values than those of
      patients sitting in bed in all regions. CONCLUSIONS: During the 20 minutes after 
      postural change from the supine to sitting positions, the cerebral activity of
      subjects sitting in a chair was higher than that of subjects sitting in bed.
FAU - Tokushige, Atsuko
AU  - Tokushige A
AD  - School of Nursing Science, Meiji University of Integrative Medicine.
FAU - Aso, Yoko
AU  - Aso Y
FAU - Ibe, Aki
AU  - Ibe A
FAU - Katayama, Megumi
AU  - Katayama M
FAU - Kimura, Shizuka
AU  - Kimura S
LA  - jpn
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Nihon Ronen Igakkai Zasshi
JT  - Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics
JID - 7507332
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Electroencephalography
MH  - Female
MH  - Humans
MH  - Male
MH  - Nursing Homes
MH  - *Posture
MH  - Supine Position
EDAT- 2011/10/15 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/10/15 06:00
PHST- 2011/10/15 06:00 [entrez]
PHST- 2011/10/15 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - JST.JSTAGE/geriatrics/48.378 [pii]
AID - 10.3143/geriatrics.48.378 [doi]
PST - ppublish
SO  - Nihon Ronen Igakkai Zasshi. 2011;48(4):378-90. doi: 10.3143/geriatrics.48.378.


PMID- 21995480
OWN - NLM
STAT- MEDLINE
DCOM- 20120518
LR  - 20111014
IS  - 1742-6723 (Electronic)
IS  - 1742-6723 (Linking)
VI  - 23
IP  - 5
DP  - 2011 Oct
TI  - Emergency medicine and futile care: Taking the road less travelled.
PG  - 640-3
LID - 10.1111/j.1742-6723.2011.01435.x [doi]
AB  - Debate around medical futility has produced a vast literature that continues to
      grow. Largely absent from the broader literature is the role of emergency
      medicine in either starting measures that prove to be futile, withholding
      treatment or starting the end of life communication process with patients and
      families. In this discussion we review the status of the futility debate in
      general, identify some of the perceived barriers in managing futile care in the
      ED including the ethical and legal issues, and establish the contribution of
      emergency medicine in this important debate. We conclude that emergency
      physicians have the clinical ability and the legal and moral standing to resist
      providing futile treatment. In these situations they can take a different path
      that focuses on comfort care thereby initiating the process of the much sought
      after 'good death'.
CI  - (c) 2011 The Authors. EMA (c) 2011 Australasian College for Emergency Medicine
      and Australasian Society for Emergency Medicine.
FAU - O'Connor, Alan E
AU  - O'Connor AE
AD  - Department of Emergency Medicine, The Royal Brisbane and Women's Hospital,
      Queensland, Australia.
FAU - Winch, Sarah
AU  - Winch S
FAU - Lukin, William
AU  - Lukin W
FAU - Parker, Malcolm
AU  - Parker M
LA  - eng
PT  - Journal Article
DEP - 20110612
PL  - Australia
TA  - Emerg Med Australas
JT  - Emergency medicine Australasia : EMA
JID - 101199824
SB  - IM
MH  - *Emergency Medicine/ethics/legislation & jurisprudence
MH  - Ethics, Medical
MH  - Humans
MH  - *Medical Futility/ethics
MH  - Terminal Care/ethics
EDAT- 2011/10/15 06:00
MHDA- 2012/05/19 06:00
CRDT- 2011/10/15 06:00
PHST- 2011/10/15 06:00 [entrez]
PHST- 2011/10/15 06:00 [pubmed]
PHST- 2012/05/19 06:00 [medline]
AID - 10.1111/j.1742-6723.2011.01435.x [doi]
PST - ppublish
SO  - Emerg Med Australas. 2011 Oct;23(5):640-3. doi: 10.1111/j.1742-6723.2011.01435.x.
      Epub 2011 Jun 12.


PMID- 21995377
OWN - NLM
STAT- MEDLINE
DCOM- 20111220
LR  - 20220815
IS  - 0020-6539 (Print)
IS  - 0020-6539 (Linking)
VI  - 61
IP  - 5
DP  - 2011 Oct
TI  - The Commonwealth as a custodian of dental migratory ethics: views of senior oral 
      health leaders from India and Australia.
PG  - 281-6
LID - 10.1111/j.1875-595X.2011.00074.x [doi]
AB  - OBJECTIVE: The Commonwealth of Nations is a unique congregation of 53 countries
      providing a platform for realistic collaboration on several social and health
      care issues. Ethical migration of health professionals from developing to
      developed countries is a key priority of the Commonwealth and several ethical
      codes have been put into practice. However, these codes have been mainly
      developed in regard to the medical workforce (physicians and nurses), and can
      have some limitations when applied to the dental profession. The aim of this
      study was to understand the role of the Commonwealth in influencing ethical
      migration of dentists from developing to developed countries, by examining the
      case of Indian-trained dentists migrating to Australia. METHODS: The research
      design involved interviewing key health care or oral health leaders in India and 
      Australia. A semi-structured interview process was designed. Grounded theory
      techniques were used in data collection and analysis. FINDINGS: Both the Indian
      and Australian participants expressed serious doubts on the Commonwealth or any
      of its Associations in influencing ethical migration of Indian trained dentists
      to Australia. Three reasons emerged: indifferent priorities, lack of funds and
      the rise of other international organisations. Bilateral cooperation between
      concerned countries was considered as a feasible alternative. CONCLUSION: The
      role of the Commonwealth as a custodian of dental migratory ethics is limited.
      Further research is required as to how bilateral cooperation between India and
      Australia could be improved. There is also an urgent need for targeted funding
      allocations in oral health, especially in the form of international aid for
      research and development both in India and Australia.
CI  - (c) 2011 FDI World Dental Federation.
FAU - Balasubramanian, Madhan
AU  - Balasubramanian M
AD  - Australian Research Centre for Population Oral Health, The University of
      Adelaide, Sydney, Australia. madhan.balasubramanian@adelaide.edu.au
FAU - Short, Stephanie
AU  - Short S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int Dent J
JT  - International dental journal
JID - 0374714
SB  - IM
MH  - Australia
MH  - Dentists/*ethics
MH  - *Developed Countries
MH  - *Developing Countries
MH  - *Emigration and Immigration
MH  - Health Priorities
MH  - India
MH  - International Agencies/*ethics
MH  - International Cooperation
MH  - Interviews as Topic
MH  - Qualitative Research
PMC - PMC9374802
EDAT- 2011/10/15 06:00
MHDA- 2011/12/21 06:00
CRDT- 2011/10/15 06:00
PHST- 2011/10/15 06:00 [entrez]
PHST- 2011/10/15 06:00 [pubmed]
PHST- 2011/12/21 06:00 [medline]
AID - 10.1111/j.1875-595X.2011.00074.x [doi]
PST - ppublish
SO  - Int Dent J. 2011 Oct;61(5):281-6. doi: 10.1111/j.1875-595X.2011.00074.x.


PMID- 21995220
OWN - NLM
STAT- MEDLINE
DCOM- 20111101
LR  - 20191112
IS  - 0269-8897 (Print)
IS  - 0269-8897 (Linking)
VI  - 24
IP  - 3
DP  - 2011 Sep
TI  - Desired machines: cinema and the world in its own image.
PG  - 329-59
AB  - In 1895 when the Lumiere brothers unveiled their cinematographic camera, many
      scientists were elated. Scientists hoped that the machine would fulfill a desire 
      that had driven research for nearly half a century: that of capturing the world
      in its own image. But their elation was surprisingly short-lived, and many
      researchers quickly distanced themselves from the new medium. The cinematographic
      camera was soon split into two machines, one for recording and one for
      projecting, enabling it to further escape from the laboratory. The philosopher
      Henri Bergson joined scientists, such as Etienne-Jules Marey, who found problems 
      with the new cinematographic order. Those who had worked to make the dream come
      true found that their efforts had been subverted. This essay focuses on the
      desire to build a cinematographic camera, with the purpose of elucidating how
      dreams and reality mix in the development of science and technology. It is about 
      desired machines and their often unexpected results. The interplay between what
      "is" (the technical), what "ought" (the ethical), and what "could" be (the
      fantastical) drives scientific research.
FAU - Canales, Jimena
AU  - Canales J
AD  - Harvard University, USA.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - England
TA  - Sci Context
JT  - Science in context
JID - 8904113
MH  - Biomedical Research/history
MH  - History, 19th Century
MH  - History, 20th Century
MH  - Motion Pictures/*history
MH  - Science/*history
EDAT- 2011/10/15 06:00
MHDA- 2011/11/02 06:00
CRDT- 2011/10/15 06:00
PHST- 2011/10/15 06:00 [entrez]
PHST- 2011/10/15 06:00 [pubmed]
PHST- 2011/11/02 06:00 [medline]
AID - 10.1017/s0269889711000147 [doi]
PST - ppublish
SO  - Sci Context. 2011 Sep;24(3):329-59. doi: 10.1017/s0269889711000147.


PMID- 21994465
OWN - NLM
STAT- MEDLINE
DCOM- 20120501
LR  - 20131121
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 2
DP  - 2012 Feb
TI  - A randomised controlled trial of ribavirin in Crimean Congo haemorrhagic fever:
      ethical considerations.
PG  - 117-20
LID - 10.1136/medethics-2011-100107 [doi]
AB  - The randomised controlled trial (RCT) constitutes a quantitative, comparative,
      controlled study of a particular treatment, and provides invaluable evidence
      regarding its pharmacotherapeutic efficacy. These studies are generally
      predicated upon the ethical principle of clinical equipoise. However, this may be
      insufficient to justify withholding treatment from a control group while
      assessing drug therapy in a potentially fatal disease. Thus, the criteria for
      randomisation, informed consent methodology and timing, and consideration of
      treatment options in such a scenario remain the province of medical ethics. This 
      paper addresses the need for an RCT of ribavirin in the treatment of Crimean
      Congo haemorrhagic fever, and highlights underlying ethical concerns in light of 
      the current medical, virological and ethical literature.
FAU - Arda, B
AU  - Arda B
AD  - Department of Medical Ethics, Faculty of Medicine, Ankara University, Ankara,
      Turkey. arda@medicine.ankara.edu.tr
FAU - Aciduman, A
AU  - Aciduman A
FAU - Johnston, J C
AU  - Johnston JC
LA  - eng
PT  - Journal Article
DEP - 20111012
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
RN  - 0 (Antiviral Agents)
RN  - 49717AWG6K (Ribavirin)
SB  - IM
MH  - Antiviral Agents/administration & dosage/*therapeutic use
MH  - Ethics, Medical
MH  - Hemorrhagic Fever Virus, Crimean-Congo
MH  - Hemorrhagic Fever, Crimean/*drug therapy/mortality
MH  - Humans
MH  - Informed Consent/ethics
MH  - Morals
MH  - Randomized Controlled Trials as Topic/*ethics
MH  - Ribavirin/administration & dosage/*therapeutic use
MH  - Treatment Outcome
EDAT- 2011/10/14 06:00
MHDA- 2012/05/02 06:00
CRDT- 2011/10/14 06:00
PHST- 2011/10/14 06:00 [entrez]
PHST- 2011/10/14 06:00 [pubmed]
PHST- 2012/05/02 06:00 [medline]
AID - medethics-2011-100107 [pii]
AID - 10.1136/medethics-2011-100107 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Feb;38(2):117-20. doi: 10.1136/medethics-2011-100107. Epub
      2011 Oct 12.


PMID- 21994358
OWN - NLM
STAT- MEDLINE
DCOM- 20120425
LR  - 20181201
IS  - 2044-5423 (Electronic)
IS  - 2044-5415 (Linking)
VI  - 21
IP  - 1
DP  - 2012 Jan
TI  - Determination of the psychometric properties of a behavioural marking system for 
      obstetrical team training using high-fidelity simulation.
PG  - 78-82
LID - 10.1136/bmjqs-2011-000296 [doi]
AB  - BACKGROUND: To determine the effectiveness of high-fidelity simulation for team
      training, a valid and reliable tool is required. This study investigated the
      internal consistency, inter-rater reliability and test-retest reliability of two 
      newly developed tools to assess obstetrical team performance. METHODS: After
      research ethics board approval, multidisciplinary obstetrical teams participated 
      in three sessions separated by 5-9 months and managed four high-fidelity
      simulation scenarios. Two tools, an 18-item Assessment of Obstetric Team
      Performance (AOTP) and a six-item Global Assessment of Obstetric Team Performance
      (GAOTP) were used.(5) Eight reviewers rated the DVDs of all teams' performances. 
      RESULTS: Two AOTP items were consistently incomplete and omitted from the
      analyses. Cronbach's alpha for the 16-item AOTP was 0.96, and 0.91 for the
      six-item GAOTP. The eight-rater alpha for the GAOTP was 0.81 (single-rater
      intra-class correlation coefficient, 0.34) indicating acceptable inter-rater
      reliability. The 'four-scenario' alpha for the 12 teams was 0.79 for session 1,
      0.88 for session 2, and 0.86 for session 3, suggesting that performance is not
      being strongly affected by the context specificity of the cases. Pearson's
      correlation of team performance scores for the four scenarios were 0.59, 0.35,
      0.40 and 0.33, and for the total score across scenarios it was 0.47, indicating
      moderate test-retest reliability. CONCLUSIONS: The results from this study
      indicate that the GAOTP would be a sufficient assessment tool for obstetrical
      team performance using simulation provided that it is used to assess teams with
      at least eight raters to ensure a sufficiently stable score. This could allow the
      quantitative evaluation of an educational intervention.
FAU - Morgan, Pamela J
AU  - Morgan PJ
AD  - Department of Anesthesia, Women's College Hospital, 76 Grenville Street, Toronto,
      ON M5S 1B2, Canada. pam.morgan@utoronto.ca
FAU - Tregunno, Deborah
AU  - Tregunno D
FAU - Pittini, Richard
AU  - Pittini R
FAU - Tarshis, Jordan
AU  - Tarshis J
FAU - Regehr, Glenn
AU  - Regehr G
FAU - Desousa, Susan
AU  - Desousa S
FAU - Kurrek, Matt
AU  - Kurrek M
FAU - Milne, Ken
AU  - Milne K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111012
PL  - England
TA  - BMJ Qual Saf
JT  - BMJ quality & safety
JID - 101546984
MH  - Clinical Competence/standards
MH  - Educational Measurement/methods
MH  - Humans
MH  - Interdisciplinary Communication
MH  - Obstetrics/*education/organization & administration/standards
MH  - *Patient Care Team/standards
MH  - Workforce
EDAT- 2011/10/14 06:00
MHDA- 2012/04/26 06:00
CRDT- 2011/10/14 06:00
PHST- 2011/10/14 06:00 [entrez]
PHST- 2011/10/14 06:00 [pubmed]
PHST- 2012/04/26 06:00 [medline]
AID - bmjqs-2011-000296 [pii]
AID - 10.1136/bmjqs-2011-000296 [doi]
PST - ppublish
SO  - BMJ Qual Saf. 2012 Jan;21(1):78-82. doi: 10.1136/bmjqs-2011-000296. Epub 2011 Oct
      12.


PMID- 21994307
OWN - NLM
STAT- MEDLINE
DCOM- 20111212
LR  - 20181201
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 343
DP  - 2011 Oct 12
TI  - Delia Smith and the ethics committee.
PG  - d6511
LID - 10.1136/bmj.d6511 [doi]
LID - bmj.d6511 [pii]
FAU - Sheehan, Mark
AU  - Sheehan M
FAU - Parker, Michael
AU  - Parker M
FAU - Dunn, Michael
AU  - Dunn M
LA  - eng
PT  - Letter
PT  - Comment
DEP - 20111012
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
SB  - IM
CON - BMJ. 2011;343:d6002. PMID: 21937564
MH  - Ethics Committees, Research/*ethics
MH  - Humans
EDAT- 2011/10/14 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/10/14 06:00
PHST- 2011/10/14 06:00 [entrez]
PHST- 2011/10/14 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 10.1136/bmj.d6511 [doi]
PST - epublish
SO  - BMJ. 2011 Oct 12;343:d6511. doi: 10.1136/bmj.d6511.


PMID- 21993903
OWN - NLM
STAT- MEDLINE
DCOM- 20120727
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 17
IP  - 4
DP  - 2011 Dec
TI  - Engaged, embedded, enjoined: science and technology studies in the National
      Science Foundation.
PG  - 823-38
LID - 10.1007/s11948-011-9307-x [doi]
AB  - Engaged scholarship is an intellectual movement sweeping across higher education,
      not only in the social and behavioral sciences but also in fields of natural
      science and engineering. It is predicated on the idea that major advances in
      knowledge will transpire when scholars, while pursuing their research interests, 
      also consider addressing the core problems confronting society. For a workable
      engaged agenda in science and technology studies, one that informs scholarship as
      well as shapes practice and policy, the traditional terms of engagement must be
      renegotiated to be more open and mutual than has historically characterized the
      nature of inquiry in this field. At the same time, it is essential to protect
      individual privacy and preserve government confidentiality. Yet there is a
      scientific possibility for and benefit to introducing more collaborative and
      deliberative research approaches between scholar and subject in ways that will
      not violate these first-order ethics. To make the case, this article discusses
      the possibilities and perils of engaged science and technology scholarship by
      drawing on our own recent experiences to conduct and apply STS research while
      embedded in the National Science Foundation. Brief accounts of these experiences 
      reveal the opportunities as well as the challenges of engaged scholarship. They
      also provide lessons for those fellow travelers who might follow the authors to
      this or other like host organizations with ambitions of increasing fundamental
      knowledge about and applying research to the policies, programs, and decisions of
      the scientific enterprise.
FAU - Hackett, Edward J
AU  - Hackett EJ
AD  - School of Human Evolution and Social Change, Arizona State University, P.O. Box
      872402, Tempe, AZ 85287-2402, USA. ehackett@asu.edu
FAU - Rhoten, Diana R
AU  - Rhoten DR
LA  - eng
PT  - Journal Article
DEP - 20111013
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
CIN - Sci Eng Ethics. 2011 Dec;17(4):839-49. PMID: 21948262
MH  - Behavioral Sciences
MH  - *Community Participation
MH  - Confidentiality
MH  - *Cooperative Behavior
MH  - Engineering
MH  - *Ethics, Research
MH  - *Financing, Government
MH  - Foundations
MH  - Humans
MH  - Knowledge
MH  - Natural Science Disciplines
MH  - Privacy
MH  - *Science
MH  - *Social Sciences
MH  - *Technology
MH  - United States
EDAT- 2011/10/14 06:00
MHDA- 2012/07/28 06:00
CRDT- 2011/10/14 06:00
PHST- 2008/03/06 00:00 [received]
PHST- 2011/08/11 00:00 [accepted]
PHST- 2011/10/14 06:00 [entrez]
PHST- 2011/10/14 06:00 [pubmed]
PHST- 2012/07/28 06:00 [medline]
AID - 10.1007/s11948-011-9307-x [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2011 Dec;17(4):823-38. doi: 10.1007/s11948-011-9307-x. Epub 2011 
      Oct 13.


PMID- 21993839
OWN - NLM
STAT- MEDLINE
DCOM- 20120207
LR  - 20111013
IS  - 1439-3522 (Electronic)
IS  - 0720-4299 (Linking)
VI  - 79
IP  - 10
DP  - 2011 Oct
TI  - [End-of-life decisions in cases of vegetative state from the legal point of
      view].
PG  - 582-7
LID - 10.1055/s-0031-1281741 [doi]
AB  - The perspective of having to "vegetate" in a so-called persistent vegetative
      state over an indefinite period of time is regarded as unacceptable by many
      people. How to operationalise and enforce the patients "right of
      self-determination" in such cases is a subject of current medical and ethical
      debate. In addition, there is great uncertainty about how far and how long
      further treatment or supply is still indicated in such cases. The article
      discusses the legal framework and illustrates existing uncertainties and points
      out those aspects that demand clarification.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Duttge, G
AU  - Duttge G
AD  - Juristische Fakultat, Zentrum fur Medizinrecht, Georg-August-Universitat
      Gottingen, Gosslerstrasse 19, 37073 Gottingen. gduttge@gwdg.de
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Therapiebegrenzende Entscheidungen in "Wachkoma"-Fallen aus rechtlicher Sicht.
DEP - 20111012
PL  - Germany
TA  - Fortschr Neurol Psychiatr
JT  - Fortschritte der Neurologie-Psychiatrie
JID - 8103137
SB  - IM
MH  - Humans
MH  - Persistent Vegetative State/*diagnosis
MH  - Personal Autonomy
MH  - Terminal Care/ethics/*legislation & jurisprudence
MH  - Withholding Treatment/ethics/legislation & jurisprudence
EDAT- 2011/10/14 06:00
MHDA- 2012/02/09 06:00
CRDT- 2011/10/14 06:00
PHST- 2011/10/14 06:00 [entrez]
PHST- 2011/10/14 06:00 [pubmed]
PHST- 2012/02/09 06:00 [medline]
AID - 10.1055/s-0031-1281741 [doi]
PST - ppublish
SO  - Fortschr Neurol Psychiatr. 2011 Oct;79(10):582-7. doi: 10.1055/s-0031-1281741.
      Epub 2011 Oct 12.


PMID- 21993806
OWN - NLM
STAT- MEDLINE
DCOM- 20120312
LR  - 20181201
IS  - 1477-030X (Electronic)
IS  - 0269-2163 (Linking)
VI  - 25
IP  - 8
DP  - 2011 Dec
TI  - The randomized fast-track trial in palliative care: role, utility and ethics in
      the evaluation of interventions in palliative care?
PG  - 741-7
LID - 10.1177/0269216311421835 [doi]
AB  - BACKGROUND: Randomized trials are the gold standard method for evaluating
      treatments and services in health care. However, they are often difficult to
      complete in palliative care, and suffer from poor recruitment. AIM: To introduce 
      the randomized fast-track trial and its potential use in palliative care. METHOD:
      The randomized fast-track trial is a form of randomized trial with two periods.
      In the first, the trial runs as a normal randomized trial. In the second period, 
      the standard (control) group also are offered the intervention. The design is
      adapted from a 'wait list' design (sometimes called a deferred entry or delayed
      intervention trial) but is both less confusing for patients, who are not on
      waiting lists, and more appropriate to the nature of services offered. The
      methodology has the advantage of being more acceptable to many patients,
      clinicians and ethics committees than standard randomized trials, because all
      patients will eventually be offered the intervention. Yet it has the rigour of a 
      traditional randomized trial. However, care is needed to ensure the correct
      timing for the first period, before the standard group receive the intervention. 
      The analysis of data in the second period is complex. CONCLUSION: The fast-track 
      trial has been used successfully in palliative care among patients severely
      affected by multiple sclerosis, chronic obstructive pulmonary disease and cancer.
      It is best suited to evaluations of palliative care services among patients who
      have longer prognoses, for example of several months or more although it has been
      used in people with prognoses of weeks.
FAU - Higginson, Irene J
AU  - Higginson IJ
AD  - Cicely Saunders Institute, King's College London, Department of Palliative Care, 
      Policy and Rehabilitation, London, UK. irene.higginson@kcl.ac.uk
FAU - Booth, Sara
AU  - Booth S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111012
PL  - England
TA  - Palliat Med
JT  - Palliative medicine
JID - 8704926
SB  - IM
MH  - Data Collection/methods
MH  - *Evaluation Studies as Topic
MH  - Humans
MH  - Multiple Sclerosis/therapy
MH  - Palliative Care/*ethics/*methods/organization & administration
MH  - *Randomized Controlled Trials as Topic
MH  - Research Design
MH  - Waiting Lists
MH  - Workforce
EDAT- 2011/10/14 06:00
MHDA- 2012/03/13 06:00
CRDT- 2011/10/14 06:00
PHST- 2011/10/14 06:00 [entrez]
PHST- 2011/10/14 06:00 [pubmed]
PHST- 2012/03/13 06:00 [medline]
AID - 0269216311421835 [pii]
AID - 10.1177/0269216311421835 [doi]
PST - ppublish
SO  - Palliat Med. 2011 Dec;25(8):741-7. doi: 10.1177/0269216311421835. Epub 2011 Oct
      12.


PMID- 21993804
OWN - NLM
STAT- MEDLINE
DCOM- 20130530
LR  - 20161125
IS  - 1477-030X (Electronic)
IS  - 0269-2163 (Linking)
VI  - 27
IP  - 1
DP  - 2013 Jan
TI  - Perceived risks around choice and decision making at end-of-life: a literature
      review.
PG  - 38-53
LID - 10.1177/0269216311424632 [doi]
AB  - BACKGROUND: the World Health Organization identifies meeting patient choice for
      care as central to effective palliative care delivery. Little is known about how 
      choice, which implies an objective balancing of options and risks, is understood 
      and enacted through decision making at end-of-life. AIM: to explore how
      perceptions of 'risk' may inform decision-making processes at end-of-life.
      DESIGN: an integrative literature review was conducted between January and
      February 2010. Papers were reviewed using Hawker et al.'s criteria and evaluated 
      according to clarity of methods, analysis and evidence of ethical consideration. 
      All literature was retained as background data, but given the significant
      international heterogeneity the final analysis specifically focused on the UK
      context. DATA SOURCE: the databases Medline, PsycINFO, Assia, British Nursing
      Index, High Wire Press and CINAHL were explored using the search terms decision*,
      risk, anxiety, hospice and palliative care, end-of-life care and publication date
      of 1998-2010. RESULTS: thematic analysis of 25 papers suggests that decision
      making at end-of-life is multifactorial, involving a balancing of risks related
      to caregiver support; service provider resources; health inequalities and access;
      challenges to information giving; and perceptions of self-identity. Overall there
      is a dissonance in understandings of choice and decision making between service
      providers and service users. CONCLUSION: the concept of risk acknowledges the
      factors that shape and constrain end-of-life choices. Recognition of perceived
      risks as a central factor in decision making would be of value in acknowledging
      and supporting meaningful decision making processes for patients with palliative 
      care needs and their families.
FAU - Wilson, F
AU  - Wilson F
AD  - Faculty of Health & Wellbeing, Sheffield Hallam University, Sheffield, UK.
      f.wilson@shu.ac.uk
FAU - Gott, M
AU  - Gott M
FAU - Ingleton, C
AU  - Ingleton C
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111012
PL  - England
TA  - Palliat Med
JT  - Palliative medicine
JID - 8704926
SB  - IM
MH  - Choice Behavior
MH  - *Decision Making
MH  - Health Services Needs and Demand
MH  - Humans
MH  - Palliative Care/*methods
MH  - Risk Factors
MH  - Terminal Care/*psychology
MH  - United Kingdom
EDAT- 2011/10/14 06:00
MHDA- 2013/06/01 06:00
CRDT- 2011/10/14 06:00
PHST- 2011/10/14 06:00 [entrez]
PHST- 2011/10/14 06:00 [pubmed]
PHST- 2013/06/01 06:00 [medline]
AID - 0269216311424632 [pii]
AID - 10.1177/0269216311424632 [doi]
PST - ppublish
SO  - Palliat Med. 2013 Jan;27(1):38-53. doi: 10.1177/0269216311424632. Epub 2011 Oct
      12.


PMID- 21992970
OWN - NLM
STAT- MEDLINE
DCOM- 20121221
LR  - 20191210
IS  - 1873-4030 (Electronic)
IS  - 1350-4533 (Linking)
VI  - 34
IP  - 7
DP  - 2012 Sep
TI  - Biomechanical and histological evaluation of abdominal wall compliance with
      intraperitoneal onlay mesh implants in rabbits: a comparison of six different
      state-of-the-art meshes.
PG  - 806-16
LID - 10.1016/j.medengphy.2011.09.022 [doi]
AB  - BACKGROUND: An ideal prosthetic mesh for incisional hernia repair should mimic
      the anisotropic compliance of the abdominal wall, and at lower loads should
      exhibit higher distensibility without impairment of safety at higher loads. This 
      study evaluated the biomechanical properties of six meshes in a rabbit model.
      METHODS: New Zealand white rabbits were used for this study. Two meshes of the
      same brand (Ethicon Physiomesh, Bard Composix((R)) L/P, Gore Dualmesh((R)), Bard 
      Sepramesh((R)), Ethicon Proceed((R)) or Parietex Composite) were implanted into
      each animal for assessment of intra-abdominal hernia repair, with a total of ten 
      meshes per group. Twelve weeks after implantation, the abdominal walls with
      ingrown meshes were harvested and examined biomechanically with a plunger test.
      The mesh-tissue compliance was evaluated by the forces exerted at given
      displacements and also described through a simple mathematical approximation.
      Abdominal wall samples were collected for histopathology, cell turnover and
      morphometry. RESULTS: No mesh-related complications were seen. The adhesion score
      was significantly higher in Bard Composix((R)) L/P and Ethicon Proceed((R))
      meshes. Significant shrinkage was seen in Gore Dualmesh((R)) and Parietex
      Composite meshes. Physiomesh exhibited the highest compliance during plunger
      testing, characterized by lower, more physiological reaction forces against
      tissue displacement than the competitor meshes. In contrast, the safety modulus
      was comparable in all groups. Histology showed less collagen and less foreign
      body reaction in the Physiomesh samples contributing to patient's comfort.
      CONCLUSION: In terms of safety, this study showed no superiority of any single
      mesh. The comfort modulus however differed, being lowest in the newly developed
      Physiomesh.
CI  - Copyright (c) 2011 IPEM. Published by Elsevier Ltd. All rights reserved.
FAU - Konerding, M A
AU  - Konerding MA
AD  - Institute of Functional and Clinical Anatomy, University Medical Center of the
      Johannes Gutenberg University Mainz, D-55099 Mainz, Germany.
      konerdin@uni-mainz.de
FAU - Chantereau, P
AU  - Chantereau P
FAU - Delventhal, V
AU  - Delventhal V
FAU - Holste, J-L
AU  - Holste JL
FAU - Ackermann, M
AU  - Ackermann M
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111010
PL  - England
TA  - Med Eng Phys
JT  - Medical engineering & physics
JID - 9422753
RN  - 0 (Adhesives)
RN  - 0 (Dioxanes)
RN  - 0 (Polyesters)
RN  - 0 (Polypropylenes)
RN  - 31621-87-1 (Polydioxanone)
RN  - 41706-81-4 (glycolide E-caprolactone copolymer)
SB  - IM
MH  - Abdominal Wall/*pathology/physiopathology
MH  - Adhesives/chemistry
MH  - Animals
MH  - Biomechanical Phenomena
MH  - Dioxanes/chemistry
MH  - Female
MH  - Herniorrhaphy/*instrumentation
MH  - Materials Testing
MH  - *Mechanical Phenomena
MH  - *Peritoneal Cavity/surgery
MH  - Polydioxanone/chemistry
MH  - Polyesters/chemistry
MH  - Polypropylenes/chemistry
MH  - Porosity
MH  - *Prostheses and Implants
MH  - Rabbits
MH  - Wound Healing
EDAT- 2011/10/14 06:00
MHDA- 2012/12/22 06:00
CRDT- 2011/10/14 06:00
PHST- 2011/04/18 00:00 [received]
PHST- 2011/09/18 00:00 [revised]
PHST- 2011/09/22 00:00 [accepted]
PHST- 2011/10/14 06:00 [entrez]
PHST- 2011/10/14 06:00 [pubmed]
PHST- 2012/12/22 06:00 [medline]
AID - S1350-4533(11)00248-7 [pii]
AID - 10.1016/j.medengphy.2011.09.022 [doi]
PST - ppublish
SO  - Med Eng Phys. 2012 Sep;34(7):806-16. doi: 10.1016/j.medengphy.2011.09.022. Epub
      2011 Oct 10.


PMID- 21992754
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20200219
IS  - 2561-8741 (Electronic)
IS  - 2561-8741 (Linking)
VI  - 18
IP  - 3
DP  - 2011
TI  - Legal and ethical considerations in meconium testing for fetal exposure to
      alcohol.
PG  - e471-4
AB  - UNLABELLED: In Canadian law, pregnant women are held to owe no enforceable duties
      of care to their children before birth, but healthcare providers may be held
      accountable once children are born alive for causing injuries prenatally. When
      children are born in hospitals, recovered meconium may be tested without consent,
      but there may be an ethical duty to inform mothers. Meconium belongs to the
      newborns, and mothers may be required to make decisions about its use in their
      children's best interests. Proposals to test meconium from particular populations
      raise concern about stigmatization. KEYWORDS: Meconium, alcohol, fatty acid ethyl
      esters, ethics, legal duties, pregnancy, fetal alcohol spectrum disorder.
FAU - Dickens, Bernard M
AU  - Dickens BM
AD  - Faculty of Law and Joint Centre for Bioethics, University of Toronto, Toronto.
      bernard.dickens@utoronto.ca
LA  - eng
PT  - Journal Article
DEP - 20111001
PL  - Australia
TA  - J Popul Ther Clin Pharmacol
JT  - Journal of population therapeutics and clinical pharmacology = Journal de la
      therapeutique des populations et de la pharmacologie clinique
JID - 101530023
SB  - IM
MH  - Canada
MH  - Decision Making
MH  - *Ethics, Medical
MH  - Female
MH  - Fetal Alcohol Spectrum Disorders/*diagnosis
MH  - Humans
MH  - Infant, Newborn
MH  - Informed Consent/*ethics/legislation & jurisprudence
MH  - Meconium/*chemistry
MH  - Pregnancy
MH  - Stereotyping
EDAT- 2011/10/14 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/10/14 06:00
PHST- 2011/10/14 06:00 [entrez]
PHST- 2011/10/14 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
PST - ppublish
SO  - J Popul Ther Clin Pharmacol. 2011;18(3):e471-4. Epub 2011 Oct 1.


PMID- 21992651
OWN - NLM
STAT- MEDLINE
DCOM- 20120322
LR  - 20111117
IS  - 1539-6924 (Electronic)
IS  - 0272-4332 (Linking)
VI  - 31
IP  - 11
DP  - 2011 Nov
TI  - Envisioning emerging nanotechnologies: a three-year panel study of South Carolina
      citizens.
PG  - 1718-33
LID - 10.1111/j.1539-6924.2011.01705.x [doi]
AB  - This article reports results from a three-year panel study of a nonrandom sample 
      of 76 South Carolina citizens, recruited from a variety of walks of life, and
      their impressions of emerging nanotechnology. This discussion focuses on material
      from depth interviews conducted alongside a baseline opinion and awareness
      inventory at the beginning of the study, the most intensive data-gathering phase.
      These results are placed in the context of data from three additional surveys
      conducted at about equal intervals over the three years, plus exit interviews
      from 21 of the 34 individuals who completed the entire study. The results give
      insight into popular thinking about technology but little indication of strong
      emerging concerns, a trajectory of amplification of those concerns, or opinion
      polarization over time, despite some awareness of risks and potential ethical
      dimensions. Nanotechnology may stand out more as an example of risk attenuation
      than of risk amplification, consistent with most results from national surveys.
CI  - (c) 2011 Society for Risk Analysis.
FAU - Priest, Susanna
AU  - Priest S
AD  - School of Environmental and Public Affairs, University of Nevada, Las Vegas, Las 
      Vegas, NV, USA. susannapriest@yahoo.com
FAU - Lane, Thomas
AU  - Lane T
FAU - Greenhalgh, Ted
AU  - Greenhalgh T
FAU - Hand, Lindsey Jo
AU  - Hand LJ
FAU - Kramer, Victoria
AU  - Kramer V
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20111012
PL  - United States
TA  - Risk Anal
JT  - Risk analysis : an official publication of the Society for Risk Analysis
JID - 8109978
SB  - IM
MH  - Data Collection
MH  - Humans
MH  - Interviews as Topic
MH  - *Nanotechnology/ethics/legislation & jurisprudence/trends
MH  - Public Opinion
MH  - *Risk Assessment
MH  - South Carolina
EDAT- 2011/10/14 06:00
MHDA- 2012/03/23 06:00
CRDT- 2011/10/14 06:00
PHST- 2011/10/14 06:00 [entrez]
PHST- 2011/10/14 06:00 [pubmed]
PHST- 2012/03/23 06:00 [medline]
AID - 10.1111/j.1539-6924.2011.01705.x [doi]
PST - ppublish
SO  - Risk Anal. 2011 Nov;31(11):1718-33. doi: 10.1111/j.1539-6924.2011.01705.x. Epub
      2011 Oct 12.


PMID- 21992627
OWN - NLM
STAT- MEDLINE
DCOM- 20111221
LR  - 20220310
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 12
DP  - 2011 Oct 12
TI  - The perceptions of Danish physiotherapists on the ethical issues related to the
      physiotherapist-patient relationship during the first session: a phenomenological
      approach.
PG  - 21
LID - 10.1186/1472-6939-12-21 [doi]
AB  - BACKGROUND: In the course of the last four decades, the profession of
      physiotherapy has progressively expanded its scope of responsibility and its
      focus on professional autonomy and evidence-based clinical practice. To preserve 
      professional autonomy, it is crucial for the physiotherapy profession to meet
      society's expectations and demands of professional competence as well as ethical 
      competence. Since it is becoming increasingly popular to choose a carrier in
      private practice in Denmark this context constitutes the frame of this study.
      Physiotherapy in private practice involves mainly a meeting between two partners:
      the physiotherapist and the patient. In the meeting, power asymmetry between the 
      two partners is a condition that the physiotherapist has to handle. The aim of
      this study was to explore whether ethical issues rise during the first
      physiotherapy session discussed from the perspective of the physiotherapists in
      private practice. METHODS: A qualitative approach was chosen and semi-structured 
      interviews with 21 physiotherapists were carried out twice and analysed by using 
      a phenomenological framework. RESULTS: Four descriptive themes emerged: general
      reflections on ethics in physiotherapy; the importance of the first physiotherapy
      session; the influence of the clinical environment on the first session and;
      reflections and actions upon beneficence towards the patient within the first
      session. The results show that the first session and the clinical context in
      private practice are essential from an ethical perspective. CONCLUSIONS: Ethical 
      issues do occur within the first session, the consciousness about ethical issues 
      differs in Danish physiotherapy private practice, and reflections and acts are to
      a lesser extent based on awareness of ethical theories, principles and ethical
      guidelines. Beneficence towards the patient is a fundamental aspect of the
      physiotherapists' understanding of the first session. However, if the
      physiotherapist lacks a deeper ethical awareness, the physiotherapist may reason 
      and/or act ethically to a varying extent: only an ethically conscious
      physiotherapist will know when he or she reflects and acts ethically. Further
      exploration of ethical issues in private practice is recommendable, and as
      management policy is deeply embedded within the Danish public sector there are
      reasons to explore public contexts of physiotherapy as well.
FAU - Praestegaard, Jeanette
AU  - Praestegaard J
AD  - Department of Physiotherapy Health Sciences, Health Sciences Center, Lund
      University, Box 157, 221 00 Lund, Sweden. j.praestegaard@oncable.dk
FAU - Gard, Gunvor
AU  - Gard G
LA  - eng
PT  - Journal Article
DEP - 20111012
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - *Beneficence
MH  - Communication
MH  - Denmark
MH  - Ethical Theory
MH  - Female
MH  - Humans
MH  - Information Dissemination
MH  - Informed Consent/ethics
MH  - Male
MH  - Middle Aged
MH  - Moral Obligations
MH  - Narration
MH  - Physical Therapists/*ethics
MH  - Power, Psychological
MH  - Private Practice/*ethics/standards/trends
MH  - *Professional Autonomy
MH  - Professional Competence
MH  - Professional-Patient Relations/*ethics
MH  - Qualitative Research
MH  - Sampling Studies
MH  - Social Perception
MH  - Surveys and Questionnaires
PMC - PMC3205020
EDAT- 2011/10/14 06:00
MHDA- 2011/12/22 06:00
CRDT- 2011/10/14 06:00
PHST- 2011/04/04 00:00 [received]
PHST- 2011/10/12 00:00 [accepted]
PHST- 2011/10/14 06:00 [entrez]
PHST- 2011/10/14 06:00 [pubmed]
PHST- 2011/12/22 06:00 [medline]
AID - 1472-6939-12-21 [pii]
AID - 10.1186/1472-6939-12-21 [doi]
PST - epublish
SO  - BMC Med Ethics. 2011 Oct 12;12:21. doi: 10.1186/1472-6939-12-21.


PMID- 21992545
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 2041-1480 (Electronic)
VI  - 2 Suppl 3
DP  - 2011
TI  - Louhi 2010: Special issue on Text and Data Mining of Health Documents.
PG  - I1
LID - 10.1186/2041-1480-2-S3-I1 [doi]
AB  - The papers presented in this supplement focus and reflect on computer use in
      every-day clinical work in hospitals and clinics such as electronic health record
      systems, pre-processing for computer aided summaries, clinical coding, computer
      decision systems, as well as related ethical concerns and security. Much of this 
      work concerns itself by necessity with incorporation and development of language 
      processing tools and methods, and as such this supplement aims at providing an
      arena for reporting on development in a diversity of languages. In the supplement
      we can read about some of the challenges identified above.
FAU - Dalianis, Hercules
AU  - Dalianis H
AD  - Department of Computer and System Sciences, (DSV) Stockholm University Forum 100,
      164 40 Kista, Sweden. hercules@dsv.su.se.
FAU - Hassel, Martin
AU  - Hassel M
FAU - Velupillai, Sumithra
AU  - Velupillai S
LA  - eng
PT  - Journal Article
DEP - 20110714
PL  - England
TA  - J Biomed Semantics
JT  - Journal of biomedical semantics
JID - 101531992
PMC - PMC3194172
EDAT- 2011/10/14 06:00
MHDA- 2011/10/14 06:01
CRDT- 2011/10/14 06:00
PHST- 2011/10/14 06:00 [entrez]
PHST- 2011/10/14 06:00 [pubmed]
PHST- 2011/10/14 06:01 [medline]
AID - 2041-1480-2-S3-I1 [pii]
AID - 10.1186/2041-1480-2-S3-I1 [doi]
PST - ppublish
SO  - J Biomed Semantics. 2011;2 Suppl 3:I1. doi: 10.1186/2041-1480-2-S3-I1. Epub 2011 
      Jul 14.


PMID- 21992269
OWN - NLM
STAT- MEDLINE
DCOM- 20120612
LR  - 20120116
IS  - 1557-8593 (Electronic)
IS  - 1520-9156 (Linking)
VI  - 14
IP  - 2
DP  - 2012 Feb
TI  - Comparison of venous plasma glucose and capillary whole blood glucose in the
      diagnosis of gestational diabetes mellitus: a community-based study.
PG  - 131-4
LID - 10.1089/dia.2011.0060 [doi]
AB  - BACKGROUND: Universal screening for gestational diabetes mellitus (GDM) is
      advocated in Indian women as they have the highest frequency of GDM among the
      South Asian population. For this the diagnostic procedure has to be simple,
      economical, and evidence based. Hence, this study was undertaken to compare
      point-of-care measured capillary whole blood glucose (CBG) with a glucometer and 
      laboratory-estimated venous plasma glucose (VPG) and to suggest which is feasible
      as a diagnostic tool. METHODS: Consecutive pregnant women in the third trimester 
      were included in this study with the approval of the institutional ethical
      committee. They were given 75 g of oral glucose in the fasting state. After 2 h, 
      CBG was measured by finger prick using an Accu-Chek((R)) glucometer (Roche
      Diagnostics India Pvt. Ltd., Mumbai, India), and venous blood was drawn to
      estimate VPG in the laboratory by the glucose oxidase-peroxidase method. The
      diagnosis of GDM was based on a 2-h plasma glucose level of >/=7.8 mmol/L (World 
      Health Organization criteria). RESULTS: Among 819 pregnant women, 86 (10.5%) were
      diagnosed as having GDM. The CBG value at a 2-h plasma glucose level of >/=7.8
      mmol/L had a sensitivity of 80.2% and specificity of 98.5% with false-positive
      and false-negative rates of 1.5% and 19.8%, respectively. The area under the
      receiver operator characteristic curve of CBG was 0.991. CONCLUSION: The CBG
      value at a 2-h plasma glucose level of >/=7.8 mmol/L may be recommended for the
      diagnosis of GDM in healthcare centers where laboratory technology is not
      available.
FAU - Balaji, Vijayam
AU  - Balaji V
AD  - Dr. V. Seshiah Diabetes Research Institute and Dr. Balaji Diabetes Care Centre,
      Chennai, India.
FAU - Madhuri, Balaji S
AU  - Madhuri BS
FAU - Paneerselvam, Arunachalam
AU  - Paneerselvam A
FAU - Arthi, Thiyagarajah
AU  - Arthi T
FAU - Seshiah, Veerasamy
AU  - Seshiah V
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111012
PL  - United States
TA  - Diabetes Technol Ther
JT  - Diabetes technology & therapeutics
JID - 100889084
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adult
MH  - Blood Glucose/*metabolism
MH  - Capillaries
MH  - Community Health Services
MH  - Diabetes, Gestational/blood/*diagnosis/epidemiology
MH  - Female
MH  - Glucose Tolerance Test
MH  - Humans
MH  - India/epidemiology
MH  - Predictive Value of Tests
MH  - Pregnancy
MH  - Pregnancy Trimester, Third
MH  - Prenatal Care/*methods
MH  - Prevalence
MH  - Prospective Studies
MH  - Risk Factors
MH  - Veins
EDAT- 2011/10/14 06:00
MHDA- 2012/06/13 06:00
CRDT- 2011/10/14 06:00
PHST- 2011/10/14 06:00 [entrez]
PHST- 2011/10/14 06:00 [pubmed]
PHST- 2012/06/13 06:00 [medline]
AID - 10.1089/dia.2011.0060 [doi]
PST - ppublish
SO  - Diabetes Technol Ther. 2012 Feb;14(2):131-4. doi: 10.1089/dia.2011.0060. Epub
      2011 Oct 12.


PMID- 21992218
OWN - NLM
STAT- MEDLINE
DCOM- 20120309
LR  - 20181201
IS  - 1941-837X (Electronic)
IS  - 1369-6998 (Linking)
VI  - 14
IP  - 6
DP  - 2011
TI  - Healthcare utilization of back pain patients: results of a claims data analysis.
PG  - 816-23
LID - 10.3111/13696998.2011.625067 [doi]
AB  - OBJECTIVES: The high life-time prevalence of chronic back pain (25-30% according 
      to surveys in small samples) suggests that it may be a major source of healthcare
      cost and that prevention of chronic back pain may be both ethically and
      economically recommendable. To obtain valid economic data on the cost of back
      pain in Germany, a retrospective claims data analysis was performed. METHODS:
      Using data from 2006 of 5.2 million beneficiaries of a German statutory health
      insurance fund (DAK Unternehmen Leben) covering ~7% of the German population,
      mean value analyses report on key healthcare utilization figures from a sickness 
      funds? perspective. In contrast to other studies, cost data are primary data and 
      not extrapolated, but clinical characteristics include surrogate markers as no
      clinical case descriptions were available. RESULTS: Based on previously
      investigated diagnosis patterns three types of back pain could be identified:
      (other) specific back pain (n=211,216), pain due to spinal disk disease
      (n=195,712), and non-specific back pain (n=534,272). Of all back pain patients,
      25.8% were identified as at risk to develop chronic pain, where only 2.6% were
      detected as patients with chronic back pain. Mean resource utilization and
      related healthcare costs were significantly higher for beneficiaries with
      indicators for chronic back pain than for beneficiaries with only risk factors
      for developing chronic back pain. This especially holds for outpatient analgesic 
      prescriptions (p<0.05), for in-hospital multimodal pain therapy (p<0.05), for
      in-hospital care in general (p<0.05), as well as for direct cost of care
      (p<0.05). CONCLUSION: The results show the potential that could be made
      accessible by an early detection of back pain patients who bear a risk of pain
      becoming chronic, both in terms of quality-of-life as well as in financial terms.
FAU - Muller-Schwefe, G
AU  - Muller-Schwefe G
AD  - German Society for Pain Therapy e.V. (DGS), Oberursel, Germany.
FAU - Freytag, A
AU  - Freytag A
FAU - Hoer, A
AU  - Hoer A
FAU - Schiffhorst, G
AU  - Schiffhorst G
FAU - Becker, A
AU  - Becker A
FAU - Casser, H-R
AU  - Casser HR
FAU - Glaeske, G
AU  - Glaeske G
FAU - Thoma, R
AU  - Thoma R
FAU - Treede, R-D
AU  - Treede RD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111012
PL  - England
TA  - J Med Econ
JT  - Journal of medical economics
JID - 9892255
SB  - IM
MH  - Absenteeism
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Back Pain/*economics/therapy
MH  - Child
MH  - Child, Preschool
MH  - Chronic Disease
MH  - Cost of Illness
MH  - Female
MH  - Germany
MH  - Health Services/*economics/*statistics & numerical data
MH  - Humans
MH  - Insurance Claim Review/statistics & numerical data
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Spinal Diseases/economics/therapy
MH  - Young Adult
EDAT- 2011/10/14 06:00
MHDA- 2012/03/10 06:00
CRDT- 2011/10/14 06:00
PHST- 2011/10/14 06:00 [entrez]
PHST- 2011/10/14 06:00 [pubmed]
PHST- 2012/03/10 06:00 [medline]
AID - 10.3111/13696998.2011.625067 [doi]
PST - ppublish
SO  - J Med Econ. 2011;14(6):816-23. doi: 10.3111/13696998.2011.625067. Epub 2011 Oct
      12.


PMID- 21992147
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1750-9378 (Electronic)
IS  - 1750-9378 (Linking)
VI  - 6 Suppl 2
DP  - 2011 Sep 23
TI  - Research collaboration with low resource countries: overcoming the challenges.
PG  - S3
LID - 10.1186/1750-9378-6-S2-S3 [doi]
AB  - The gap in research capacity between low and high resource countries and the
      effect on the global trend of health research cannot be ignored any more.
      Therefore the need for research collaboration between the two groups cannot be
      overemphasized. The discrepancy of economies makes for differences in research
      capacity, psychosocial needs, ethical considerations, focus and challenges. For
      such collaboration to work out, every collaborator needs to be aware of these
      challenges and work with them. Collaborations with low resource countries will
      require transparency, mutual respect and respect for social norms. Collaborations
      should no longer be that of taker or master, but of cooperation. The dearth of
      adequate research manpower and well equipped laboratories in low resource
      countries calls for a deliberate effort by strong research centers to go a step
      further in collaboration and adopt a centre or laboratory.
FAU - Akinremi, Titilola O
AU  - Akinremi TO
AD  - Dept of Pathology, Federal Medical Center, Abeokuta, Nigeria. bakinremi2@aol.com.
LA  - eng
PT  - Journal Article
DEP - 20110923
PL  - England
TA  - Infect Agent Cancer
JT  - Infectious agents and cancer
JID - 101276559
PMC - PMC3194182
EDAT- 2011/10/14 06:00
MHDA- 2011/10/14 06:01
CRDT- 2011/10/14 06:00
PHST- 2011/10/14 06:00 [entrez]
PHST- 2011/10/14 06:00 [pubmed]
PHST- 2011/10/14 06:01 [medline]
AID - 1750-9378-6-S2-S3 [pii]
AID - 10.1186/1750-9378-6-S2-S3 [doi]
PST - ppublish
SO  - Infect Agent Cancer. 2011 Sep 23;6 Suppl 2:S3. doi: 10.1186/1750-9378-6-S2-S3.
      Epub 2011 Sep 23.


PMID- 21992076
OWN - NLM
STAT- MEDLINE
DCOM- 20120321
LR  - 20131121
IS  - 1473-4877 (Electronic)
IS  - 0300-7995 (Linking)
VI  - 27
IP  - 12
DP  - 2011 Dec
TI  - A randomized comparison of to-aqueous penetration of ketorolac 0.45%, bromfenac
      0.09% and nepafenac 0.1% in cataract patients undergoing phacoemulsification.
PG  - 2235-9
LID - 10.1185/03007995.2011.626018 [doi]
AB  - OBJECTIVE: To compare the peak to-aqueous penetration of three nonsteroidal
      anti-inflammatory drugs: ketorolac tromethamine 0.45%, bromfenac 0.09%, nepafenac
      0.1%, and amfenac (the active metabolite of nepafenac) in patients undergoing
      phacoemulsification. METHODS: A single center, double-masked study randomized 122
      patients to receive one of three treatment arms. On-label dosing of ketorolac
      (BID), bromfenac (BID), and nepafenac (TID) was instructed for 1 day prior to
      surgery. Patients were instructed to instill one drop the morning of surgery. The
      patients received four additional doses 1 hour prior to phacoemulsification.
      After completion of the paracentesis site with a superblade, aqueous humor (0.15 
      cc) was collected through the peripheral clear cornea with a 30-gauge needle
      attached to a TB syringe. Following collection, aqueous samples were stored at
      -40 degrees C prior to analysis. Drug concentrations were analyzed by liquid
      chromatography tandem mass spectrometry using positive turbo-ion spray ionization
      and multiple reaction monitoring mode for quantification. An independent sample
      Student's t-test was used to detect between-group differences. RESULTS: The peak 
      aqueous concentration of ketorolac 0.45% was 10 times the concentration of
      bromfenac 0.09%, and five times the concentration of and 54% greater than the
      metabolically inactive nepafenac 0.1%. The mean peak aqueous concentration of
      ketorolac 0.45% was 688.87 +/- 749.6 ng/ml. Bromfenac achieved a mean peak
      aqueous concentration of 67.64 +/- 62.4 ng/ml. The mean peak aqueous
      concentrations of nepafenac and amfenac were 447.10 +/- 225.7 ng/ml and 140.37
      +/- 56.6 ng/ml, respectively. The peak concentration of ketorolac was
      statistically significantly greater than bromfenac (P </= 0.0005), nepafenac (P
      </= 0.05), and amfenac (P </= 0.005). A limitation of this study is that aqueous 
      samples were collected just prior to surgery and not during the postoperative
      period due to ethical considerations. CONCLUSIONS: Ketorolac 0.45% achieved
      significantly greater aqueous concentrations when compared to bromfenac 0.09% and
      the active metabolite of nepafenac 0.1% (amfenac) in patients undergoing
      phacoemulsification.
FAU - Bucci, Frank A Jr
AU  - Bucci FA Jr
AD  - Bucci Laser Vision Institute, Wilkes-Barre, PA 18702, USA. buccivision@aol.com
FAU - Waterbury, L David
AU  - Waterbury LD
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20111012
PL  - England
TA  - Curr Med Res Opin
JT  - Current medical research and opinion
JID - 0351014
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Benzeneacetamides)
RN  - 0 (Benzophenones)
RN  - 0 (Bromobenzenes)
RN  - 0 (Phenylacetates)
RN  - 0J9L7J6V8C (nepafenac)
RN  - 864P0921DW (bromfenac)
RN  - YZI5105V0L (Ketorolac)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/*pharmacokinetics
MH  - Benzeneacetamides/administration & dosage/*pharmacokinetics
MH  - Benzophenones/administration & dosage/*pharmacokinetics
MH  - Bromobenzenes/administration & dosage/*pharmacokinetics
MH  - Cataract/*drug therapy/metabolism
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Ketorolac/administration & dosage/*pharmacokinetics
MH  - Male
MH  - Middle Aged
MH  - Phenylacetates/administration & dosage/*pharmacokinetics
EDAT- 2011/10/14 06:00
MHDA- 2012/03/22 06:00
CRDT- 2011/10/14 06:00
PHST- 2011/10/14 06:00 [entrez]
PHST- 2011/10/14 06:00 [pubmed]
PHST- 2012/03/22 06:00 [medline]
AID - 10.1185/03007995.2011.626018 [doi]
PST - ppublish
SO  - Curr Med Res Opin. 2011 Dec;27(12):2235-9. doi: 10.1185/03007995.2011.626018.
      Epub 2011 Oct 12.


PMID- 21992000
OWN - NLM
STAT- MEDLINE
DCOM- 20120426
LR  - 20111206
IS  - 1442-2042 (Electronic)
IS  - 0919-8172 (Linking)
VI  - 18
IP  - 12
DP  - 2011 Dec
TI  - Laparoscopic transvesical removal of erosive mesh after transobturator tape
      procedure.
PG  - 861-3
LID - 10.1111/j.1442-2042.2011.02869.x [doi]
AB  - We have experienced two cases of intravesical transobturator tape (TOT) tape
      successfully removed by laparoscopic transvesical procedure. Patient 1 was a
      67-year-old woman complaining of irritative symptoms of the urinary bladder. In
      another hospital she had undergone anterior corporrhaphy and a TOT procedure to
      treat a cystocele and stress urinary incontinence (SUI) 17 months before the
      initial consultation. A cystoscopy revealed tape extrusion and adherent calculi
      at the 4 to 5 O'clock position of the bladder neck. After filling the bladder
      with carbon dioxide, three 5-mm ports were placed in lower abdomen directly into 
      the bladder. The tape extruding from the bladder muscle layer was completely
      excised, and extirpated with the adherent calculi. The bladder mucosa and muscle 
      layer were continuously sutured using 4-0 Vicryl (Ethicon Inc., Somerville, NJ,
      USA). The port entry sites were closed under direct vision using 4-0 Vicryl. SUI 
      recurred 15 months later and a second TOT surgery was performed. Neither SUI nor 
      mesh extrusion have been observed during the 18 months following the second TOT. 
      Patient 2 was a 74-year-old woman. She consulted our hospital for the removal of 
      an intravesically extruded tape and adherent calculi. She had undergone a vaginal
      hysterectomy and TOT surgery for uterine prolapse and SUI at another hospital 3
      years before her visit. A cystoscopy revealed tape extrusion and adherent calculi
      on the right bladder wall. We performed an endoscopic transvesical extirpation of
      the intravesical foreign bodies in a same manner described below. There has been 
      no recurrent SUI or mesh erosion during the 18-month follow up.
CI  - (c) 2011 The Japanese Urological Association.
FAU - Yoshizawa, Tsuyoshi
AU  - Yoshizawa T
AD  - Department of Urology, Nihon University School of Medicine, Tokyo, Japan.
FAU - Yamaguchi, Kenya
AU  - Yamaguchi K
FAU - Obinata, Daisuke
AU  - Obinata D
FAU - Sato, Katsuhiko
AU  - Sato K
FAU - Mochida, Junichi
AU  - Mochida J
FAU - Takahashi, Satoru
AU  - Takahashi S
LA  - eng
PT  - Journal Article
DEP - 20111012
PL  - Australia
TA  - Int J Urol
JT  - International journal of urology : official journal of the Japanese Urological
      Association
JID - 9440237
SB  - IM
MH  - Aged
MH  - Device Removal/*methods
MH  - Female
MH  - Humans
MH  - Laparoscopy/*methods
MH  - Prosthesis Failure/*adverse effects
MH  - Recurrence
MH  - Suburethral Slings/*adverse effects
MH  - Urinary Bladder Calculi/etiology/surgery
MH  - Urinary Incontinence, Stress/surgery
EDAT- 2011/10/14 06:00
MHDA- 2012/04/27 06:00
CRDT- 2011/10/14 06:00
PHST- 2011/10/14 06:00 [entrez]
PHST- 2011/10/14 06:00 [pubmed]
PHST- 2012/04/27 06:00 [medline]
AID - 10.1111/j.1442-2042.2011.02869.x [doi]
PST - ppublish
SO  - Int J Urol. 2011 Dec;18(12):861-3. doi: 10.1111/j.1442-2042.2011.02869.x. Epub
      2011 Oct 12.


PMID- 21968079
OWN - NLM
STAT- MEDLINE
DCOM- 20120207
LR  - 20211020
IS  - 1758-2652 (Electronic)
IS  - 1758-2652 (Linking)
VI  - 14 Suppl 2
DP  - 2011 Sep 27
TI  - Framing the social in biomedical HIV prevention trials: a 20-year retrospective.
PG  - S3
LID - 10.1186/1758-2652-14-S2-S3 [doi]
AB  - Biomedical research is critical to identifying effective and safe interventions, 
      such as vaccines, microbicides, male circumcision and antiretrovirals, for
      prevention. Funding for clinical prevention trials is highly competitive and the 
      benchmarks of success ultimately reduce to quickly enrolling a select group of
      people at risk, keeping them enrolled, and inducing them to be compliant with
      trial requirements - all at the lowest cost possible. Juxtaposed with this
      reality is the fact that HIV is situated with poverty, exploitation, assaults on 
      human dignity, and human rights abuses. The result is a complex web of ethical
      challenges that are socially constructed along lines of wealth and power. While
      social science research methods are commonly employed to examine such topics,
      they have played a marginal role in biomedical HIV prevention research. Why? To
      answer this question, a core set of persistent interlocking social, behavioural
      and ethical challenges to biomedical HIV prevention research are described. A
      critique is offered on how the social has been framed relative to the
      behavioural, ethical and biomedical components. Examples of how this framing has 
      devalued social knowledge are provided, including the conflation of qualitative
      research with anecdotal reporting, a bias toward brevity and accuracy over
      external validity, and difficulties in distinguishing between a moral
      understanding of social norms and achieving a moral outcome when confronted with 
      ethical challenges in research. Lastly, opportunities are identified for
      enhancing the success of biomedical HIV prevention research through development
      of a coherent programme of social science research. Recommendations are offered
      for reframing the social as a valid domain of scientific inquiry in this highly
      applied and interdisciplinary context.
FAU - MacQueen, Kathleen M
AU  - MacQueen KM
AD  - Behavioral and Social Sciences, FHI360, 2224 ENC Hwy 54, Durham, NC 27713, USA.
      kmacqueen@fhi360.org
LA  - eng
PT  - Editorial
PT  - Review
DEP - 20110927
PL  - Switzerland
TA  - J Int AIDS Soc
JT  - Journal of the International AIDS Society
JID - 101478566
SB  - IM
MH  - *Biomedical Research/ethics
MH  - *Clinical Trials as Topic
MH  - Female
MH  - HIV Infections/drug therapy/*prevention & control/psychology
MH  - Humans
MH  - Male
MH  - Retrospective Studies
MH  - *Social Sciences/ethics
PMC - PMC3194162
EDAT- 2011/10/14 06:00
MHDA- 2012/02/09 06:00
CRDT- 2011/10/05 06:00
PHST- 2011/10/05 06:00 [entrez]
PHST- 2011/10/14 06:00 [pubmed]
PHST- 2012/02/09 06:00 [medline]
AID - 1758-2652-14-S2-S3 [pii]
AID - 10.1186/1758-2652-14-S2-S3 [doi]
PST - epublish
SO  - J Int AIDS Soc. 2011 Sep 27;14 Suppl 2:S3. doi: 10.1186/1758-2652-14-S2-S3.


PMID- 21961667
OWN - NLM
STAT- MEDLINE
DCOM- 20120123
LR  - 20220408
IS  - 1873-2607 (Electronic)
IS  - 0749-3797 (Linking)
VI  - 41
IP  - 4 Suppl 3
DP  - 2011 Oct
TI  - Reuniting public health and medicine: the University of New Mexico School of
      Medicine Public Health Certificate.
PG  - S214-9
LID - 10.1016/j.amepre.2011.06.001 [doi]
AB  - The University of New Mexico School of Medicine (UNMSOM) sought to train medical 
      students in public health concepts, knowledge, and skills as a means of improving
      the health of communities statewide. Faculty members from every UNMSOM department
      collaborated to create and integrate a public health focus into all years of the 
      medical school curriculum. They identified key competencies and developed new
      courses that would synchronize students' learning public health subjects with the
      mainstream medical school content. New courses include: Health Equity: Principles
      of Public Health; Epidemiology and Biostatistics; Evidence-Based Practice;
      Community-Based Service Learning; and Ethics in Public Health. Students
      experiencing the new courses, first in pilot and then final forms, gave high
      quantitative ratings to all courses. Some students' qualitative comments suggest 
      that the Public Health Certificate has had a profound transformative effect.
      Instituting the integrated Public Health Certificate at UNMSOM places it among
      the first medical schools to require all its medical students to complete medical
      school with public health training. The new UNMSOM Public Health Certificate
      courses reunite medicine and public health in a unified curriculum.
CI  - Copyright (c) 2011 American Journal of Preventive Medicine. Published by Elsevier
      Inc. All rights reserved.
FAU - Geppert, Cynthia M A
AU  - Geppert CM
AD  - Department of Psychiatry, Veterans Administration Medical Center, University of
      New Mexico, Albuquerque, New Mexico 87131, USA.
FAU - Arndell, Cynthia L
AU  - Arndell CL
FAU - Clithero, Amy
AU  - Clithero A
FAU - Dow-Velarde, Lily A
AU  - Dow-Velarde LA
FAU - Eldredge, Jonathan D
AU  - Eldredge JD
FAU - Kalishman, Summers
AU  - Kalishman S
FAU - Kaufman, Arthur
AU  - Kaufman A
FAU - McGrew, Martha C
AU  - McGrew MC
FAU - Snyder, Tiffany M
AU  - Snyder TM
FAU - Solan, Brian G
AU  - Solan BG
FAU - Timm, Craig T
AU  - Timm CT
FAU - Tollestrup, Kristine
AU  - Tollestrup K
FAU - Wagner, Lana K
AU  - Wagner LK
FAU - Wiese, William H
AU  - Wiese WH
FAU - Wiggins, Charles L
AU  - Wiggins CL
FAU - Cosgrove, Ellen M
AU  - Cosgrove EM
LA  - eng
GR  - 5U36CD319276/CD/ODCDC CDC HHS/United States
GR  - D56HP08339-02-00/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Am J Prev Med
JT  - American journal of preventive medicine
JID - 8704773
SB  - IM
EIN - Am J Prev Med. 2012 Jul;43(1):123. Eldredge, Jonathan P [corrected to Eldredge,
      Jonathan D]
MH  - *Certification
MH  - Clinical Competence
MH  - Cooperative Behavior
MH  - Curriculum
MH  - Education, Medical/*organization & administration
MH  - Faculty, Medical/organization & administration
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - New Mexico
MH  - Public Health/*education
MH  - Schools, Medical
MH  - Students, Medical
EDAT- 2011/10/14 06:00
MHDA- 2012/01/24 06:00
CRDT- 2011/10/04 06:00
PHST- 2011/01/04 00:00 [received]
PHST- 2011/05/11 00:00 [revised]
PHST- 2011/06/01 00:00 [accepted]
PHST- 2011/10/04 06:00 [entrez]
PHST- 2011/10/14 06:00 [pubmed]
PHST- 2012/01/24 06:00 [medline]
AID - S0749-3797(11)00356-4 [pii]
AID - 10.1016/j.amepre.2011.06.001 [doi]
PST - ppublish
SO  - Am J Prev Med. 2011 Oct;41(4 Suppl 3):S214-9. doi: 10.1016/j.amepre.2011.06.001.


PMID- 21961661
OWN - NLM
STAT- MEDLINE
DCOM- 20120123
LR  - 20211020
IS  - 1873-2607 (Electronic)
IS  - 0749-3797 (Linking)
VI  - 41
IP  - 4 Suppl 3
DP  - 2011 Oct
TI  - Integration of community health teaching in the undergraduate medicine curriculum
      at the University of Toronto.
PG  - S176-80
LID - 10.1016/j.amepre.2011.06.003 [doi]
AB  - BACKGROUND: In 1999, Determinants of Community Health was introduced at the
      Faculty of Medicine, University of Toronto. The course spanned all 4 years of the
      undergraduate curriculum and focused on addressing individual patient and
      community needs, prevention and population health, and diverse learning contexts.
      PURPOSE: To demonstrate the value of an integrated, longitudinal approach to the 
      efficiency of delivering a public health curriculum. DESIGN: Time-series
      comparing the curricular change over two periods of time. SETTING/PARTICIPANTS:
      Undergraduate medical students from 1993 to 2009. INTERVENTION: Using a spiral
      curriculum, the educational materials are integrated across all 4 years, based on
      the concept of medical decision making in a community context. MAIN OUTCOME
      MEASURES: This study compares measures of student satisfaction and national
      rankings of the University of Toronto with the other 16 Canadian medical schools 
      for the "Population Health, Ethical, Legal, and Organizational aspects of the
      practice of medicine" component of the Medical Council of Canada Qualifying
      Examination Part 1. RESULTS: The University of Toronto has been ranked either
      first or second place nationally, in comparison to lower rankings in previous
      years (p<0.02 on the Kruskal-Wallis test). Student ratings indicated the course
      was comparable to others in the curriculum. CONCLUSIONS: For the same amount of
      curricular time, an integrated spiral curriculum for teaching public health
      appears to be more effective than traditional approaches.
CI  - Copyright (c) 2011 American Journal of Preventive Medicine. Published by Elsevier
      Inc. All rights reserved.
FAU - Johnson, Ian L
AU  - Johnson IL
AD  - Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario,
      Canada. ian.johnson@oahpp.ca
FAU - Scott, Fran E
AU  - Scott FE
FAU - Byrne, Niall P
AU  - Byrne NP
FAU - MacRury, Katherine A
AU  - MacRury KA
FAU - Rosenfield, Jay
AU  - Rosenfield J
LA  - eng
GR  - U36 CD319276/CD/ODCDC CDC HHS/United States
GR  - 5U36CD319276/CD/ODCDC CDC HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Am J Prev Med
JT  - American journal of preventive medicine
JID - 8704773
SB  - IM
MH  - Canada
MH  - Community Health Services/*organization & administration
MH  - Curriculum/trends
MH  - Decision Making
MH  - Education, Medical, Undergraduate/*organization & administration/trends
MH  - Humans
MH  - Ontario
MH  - Public Health/*education
MH  - Students, Medical/psychology/statistics & numerical data
MH  - Time Factors
PMC - PMC7126546
EDAT- 2011/10/14 06:00
MHDA- 2012/01/24 06:00
CRDT- 2011/10/04 06:00
PHST- 2011/01/06 00:00 [received]
PHST- 2011/05/17 00:00 [revised]
PHST- 2011/06/02 00:00 [accepted]
PHST- 2011/10/04 06:00 [entrez]
PHST- 2011/10/14 06:00 [pubmed]
PHST- 2012/01/24 06:00 [medline]
AID - S0749-3797(11)00364-3 [pii]
AID - 10.1016/j.amepre.2011.06.003 [doi]
PST - ppublish
SO  - Am J Prev Med. 2011 Oct;41(4 Suppl 3):S176-80. doi: 10.1016/j.amepre.2011.06.003.


PMID- 21989752
OWN - NLM
STAT- MEDLINE
DCOM- 20111215
LR  - 20111012
IS  - 0303-7339 (Print)
IS  - 0303-7339 (Linking)
VI  - 53
IP  - 10
DP  - 2011
TI  - [Biology and psychiatry: ethical aspects of the prevention of antisocial
      behaviour in children].
PG  - 739-49
AB  - BACKGROUND: Genetic and neurobiological research into the causes of antisocial
      behaviour is playing an increasingly important role in forensic psychiatry. AIM: 
      To contribute some ethical and societal reflections on the possible consequences 
      of this kind of research for the prevention of antisocial behaviour. METHOD: In
      this ethical analysis, which gives attention to the concepts of 'informed
      consent' and 'best interests', we investigate which persons and which interests
      need to be taken into account when new preventive measures are implemented.
      RESULTS: It is important to differentiate between distinct target groups. From an
      ethical point of view it makes a difference whether measures are related to the
      early identification of a-symptomatic high-risk children and appropriate
      preventive interventions, or whether they are directed towards the (sub)typing
      and preventive treatment of children who already have behavioural problems or
      whether they are concerned with the treatment of children with conduct disorders 
      whose parents have asked the child psychiatrist for assistance. CONCLUSION: From 
      an ethical point of view it is not really important whether prevention measures
      are based on genetic and neurobiological research or on societal and
      psychological research. What is more important is that these measures target
      particular groups of children and that prevention is implemented in an
      appropriate manner.
FAU - Horstkotter, D
AU  - Horstkotter D
AD  - School for Public Health and Primary care, Nijmegen.
      d.horstkoetter@maastrichtuniversity.nl
FAU - Berghmans, R L P
AU  - Berghmans RL
FAU - Slatman, J
AU  - Slatman J
FAU - de Wert, G
AU  - de Wert G
LA  - dut
PT  - English Abstract
PT  - Journal Article
TT  - Biologie en psychiatrie: ethische aspecten van de preventie van antisociaal
      gedrag bij kinderen.
PL  - Netherlands
TA  - Tijdschr Psychiatr
JT  - Tijdschrift voor psychiatrie
JID - 0423731
SB  - IM
MH  - Antisocial Personality Disorder/genetics/*prevention & control/psychology
MH  - Child
MH  - *Child Behavior
MH  - Child Psychiatry/*ethics/*methods
MH  - Humans
EDAT- 2011/10/13 06:00
MHDA- 2011/12/16 06:00
CRDT- 2011/10/13 06:00
PHST- 2011/10/13 06:00 [entrez]
PHST- 2011/10/13 06:00 [pubmed]
PHST- 2011/12/16 06:00 [medline]
AID - TVPart_9215 [pii]
PST - ppublish
SO  - Tijdschr Psychiatr. 2011;53(10):739-49.


PMID- 21989549
OWN - NLM
STAT- MEDLINE
DCOM- 20120612
LR  - 20211020
IS  - 1496-8975 (Electronic)
IS  - 0832-610X (Linking)
VI  - 58
IP  - 12
DP  - 2011 Dec
TI  - Risk factors for urinary retention after hip or knee replacement: a cohort study.
PG  - 1097-104
LID - 10.1007/s12630-011-9595-2 [doi]
AB  - INTRODUCTION: In 2006, our provincial government initiated a program to reduce
      wait times for total hip or knee replacements by referring patients to a single
      tertiary-care centre. This program provided an opportunity to identify risk
      factors for perioperative complications as part of a continuing quality
      improvement project. We report the risk of postoperative urinary retention after 
      hip and knee replacements and the risk factors associated with this complication.
      METHODS: After local Research Ethics Board approval, data were abstracted from
      charts of patients who underwent elective primary unilateral total hip or knee
      replacement surgery. The outcome was urinary retention in the first 24 hr after
      surgery. Risk factors were identified using multivariable logistic regression,
      and they were expressed as odds ratios (OR) or 95% confidence intervals (CI).
      RESULTS: From April 1, 2006 to May 31, 2007, 1,440 patients underwent 1,515
      elective total hip replacement or total knee replacement. We abstracted data from
      1,031 (71.3%) patients: mean age, 62 yr (interquartile range [IQR] 55-70); 53.7% 
      female; 605 total hip replacements; and 426 total knee replacements. The
      procedures were performed under spinal (81.8%), general (10.2%), or combined
      spinal and general (8.0%) anesthesia. Patients spent 100 [IQR 90-114] min in the 
      operating room and 3 [IQR 3-4] days in hospital. The 24-hr incidence of urinary
      retention was 43.3% (446/1031). Male sex (odds ratio [OR] 3.9; 95% CI 3.0 to
      5.2), total hip replacement (OR 1.4; 95% CI 1.1 to 1.9), and intrathecal morphine
      were risk factors. DISCUSSION: Postoperative urinary retention is a common
      complication after total hip or total knee replacement, especially amongst men
      and patients receiving intrathecal morphine.
FAU - Griesdale, Donald E G
AU  - Griesdale DE
AD  - Department of Anesthesiology, Pharmacology and Therapeutics, University of
      British Columbia, 3300 - 910 Tenth Avenue West, Vancouver, BC V5Z 4E3, Canada.
FAU - Neufeld, Jeremy
AU  - Neufeld J
FAU - Dhillon, Dale
AU  - Dhillon D
FAU - Joo, Jennifer
AU  - Joo J
FAU - Sandhu, Supna
AU  - Sandhu S
FAU - Swinton, Frank
AU  - Swinton F
FAU - Choi, Peter T
AU  - Choi PT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111012
PL  - United States
TA  - Can J Anaesth
JT  - Canadian journal of anaesthesia = Journal canadien d'anesthesie
JID - 8701709
RN  - 0 (Analgesics, Opioid)
RN  - 76I7G6D29C (Morphine)
SB  - IM
MH  - Aged
MH  - Analgesics, Opioid/administration & dosage/adverse effects
MH  - Anesthesia, General/methods
MH  - Anesthesia, Spinal/methods
MH  - Arthroplasty, Replacement, Hip/*methods
MH  - Arthroplasty, Replacement, Knee/*methods
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Injections, Spinal
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Morphine/administration & dosage/adverse effects
MH  - Multivariate Analysis
MH  - Postoperative Complications/*epidemiology
MH  - Quality Assurance, Health Care
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Sex Factors
MH  - Urinary Retention/epidemiology/*etiology
PMC - PMC3219865
EDAT- 2011/10/13 06:00
MHDA- 2012/06/13 06:00
CRDT- 2011/10/13 06:00
PHST- 2011/04/06 00:00 [received]
PHST- 2011/09/14 00:00 [accepted]
PHST- 2011/10/13 06:00 [entrez]
PHST- 2011/10/13 06:00 [pubmed]
PHST- 2012/06/13 06:00 [medline]
AID - 10.1007/s12630-011-9595-2 [doi]
PST - ppublish
SO  - Can J Anaesth. 2011 Dec;58(12):1097-104. doi: 10.1007/s12630-011-9595-2. Epub
      2011 Oct 12.


PMID- 21989510
OWN - NLM
STAT- MEDLINE
DCOM- 20120207
LR  - 20111012
IS  - 1439-3522 (Electronic)
IS  - 0720-4299 (Linking)
VI  - 79
IP  - 10
DP  - 2011 Oct
TI  - [Best interests in the 'vegetative state'].
PG  - 576-81
LID - 10.1055/s-0031-1281736 [doi]
AB  - Treatment decisions for patients in the vegetative state often have to be based
      on the patient's best interests, if the patient's will is not known. Physicians
      are, however, highly uncertain what kind of treatment is in such a difficult
      situation the patient's best interests. This article presents new insights from
      neuroscience and shows how treatment decision making should proceed to reach an
      ethically justified decision. Pivotal elements are a careful diagnosis using
      validated behavioural scales, an informed judgment about the existence of
      awareness and sentience, and an early prognostic assessment. As new imaging
      techniques and treatment options are not yet clinical standard due to low
      evidence, the best interests have to be judged in the context of uncertainty. The
      leading question should be whether the preferred treatment goal can be achieved
      with a realistic probability and a justifiable benefit-harm-ratio. This has to be
      judged for the individual patient, considering his personality and communicating 
      with the family members. There cannot be a general answer to the question of best
      interests in the vegetative state, but only an individual answer in shared
      responsibility and based on the particular features of a special case.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Jox, R J
AU  - Jox RJ
AD  - Institut fur Ethik, Geschichte und Theorie der Medizin,
      Ludwig-Maximilians-Universitat Munchen, Lessingstrasse 2, 80336 Munchen.
      ralf.jox@med.lmu.de
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Arztliche Indikation beim "Wachkoma".
DEP - 20111011
PL  - Germany
TA  - Fortschr Neurol Psychiatr
JT  - Fortschritte der Neurologie-Psychiatrie
JID - 8103137
SB  - IM
MH  - Advance Directives
MH  - Humans
MH  - Neurosciences/*ethics
MH  - Persistent Vegetative State/diagnosis/*therapy
MH  - Prognosis
MH  - Terminal Care/*ethics
EDAT- 2011/10/13 06:00
MHDA- 2012/02/09 06:00
CRDT- 2011/10/13 06:00
PHST- 2011/10/13 06:00 [entrez]
PHST- 2011/10/13 06:00 [pubmed]
PHST- 2012/02/09 06:00 [medline]
AID - 10.1055/s-0031-1281736 [doi]
PST - ppublish
SO  - Fortschr Neurol Psychiatr. 2011 Oct;79(10):576-81. doi: 10.1055/s-0031-1281736.
      Epub 2011 Oct 11.


PMID- 21989508
OWN - NLM
STAT- MEDLINE
DCOM- 20120207
LR  - 20111012
IS  - 1439-3522 (Electronic)
IS  - 0720-4299 (Linking)
VI  - 79
IP  - 10
DP  - 2011 Oct
TI  - [Ethics and neuroscience: article series neuroethics].
PG  - 559-60
LID - 10.1055/s-0031-1281735 [doi]
FAU - Woopen, C
AU  - Woopen C
FAU - Vogeley, K
AU  - Vogeley K
LA  - ger
PT  - Editorial
TT  - Ethik und die Neurowissenschaften: Beitragsreihe Neuroethik.
DEP - 20111011
PL  - Germany
TA  - Fortschr Neurol Psychiatr
JT  - Fortschritte der Neurologie-Psychiatrie
JID - 8103137
SB  - IM
MH  - Bioethical Issues
MH  - Ethics, Research
MH  - Neurosciences/*ethics
EDAT- 2011/10/13 06:00
MHDA- 2012/02/09 06:00
CRDT- 2011/10/13 06:00
PHST- 2011/10/13 06:00 [entrez]
PHST- 2011/10/13 06:00 [pubmed]
PHST- 2012/02/09 06:00 [medline]
AID - 10.1055/s-0031-1281735 [doi]
PST - ppublish
SO  - Fortschr Neurol Psychiatr. 2011 Oct;79(10):559-60. doi: 10.1055/s-0031-1281735.
      Epub 2011 Oct 11.


PMID- 21988953
OWN - NLM
STAT- MEDLINE
DCOM- 20120214
LR  - 20111012
IS  - 1535-2811 (Electronic)
IS  - 1535-2811 (Linking)
VI  - 10
IP  - 2
DP  - 2011 Jun
TI  - Integrating voices of survivors into the system of care post-cardiac arrest.
PG  - 113-4
LID - 10.1097/HPC.0b013e318223c3bc [doi]
AB  - The management of patients after cardiac arrest is a prominent example of
      complexity on many levels of decisions. We designed a pathway for the management 
      of survivors of cardiac arrest, guiding such decisions as cardiac
      catheterization, induction of therapeutic hypothermia, placement of
      defibrillator, and ethical decision making for life support. Our pathway outlines
      the comprehensive management of patients from the field through the emergency
      room, the cardiac catheterization laboratory, the cardiac care unit, step down
      unit, and the rehabilitation center. Involving patients and their families is a
      novel addition to a clinical pathway. We used the power of survivors' stories to 
      inspire and educate clinicians in the utility of our multidisciplinary pathway
      approach. This approach may serve as a model for patient-centered care in
      medicine.
FAU - Herzog, Eyal
AU  - Herzog E
AD  - Divisions of Cardiology, Department of Medicine, St. Luke's and Roosevelt
      Hospital Center, New York 10025, USA. eherzog@chpnet
FAU - Aziz, Emad F
AU  - Aziz EF
FAU - Shapiro, Janet M
AU  - Shapiro JM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Crit Pathw Cardiol
JT  - Critical pathways in cardiology
JID - 101165286
SB  - IM
MH  - Advanced Cardiac Life Support/*methods/psychology
MH  - Critical Pathways/*trends
MH  - Disease Management
MH  - Emergency Medical Services/organization & administration
MH  - Heart Arrest/*psychology/therapy
MH  - Humans
MH  - Life Change Events
MH  - Patient Participation/*methods
MH  - *Patient-Centered Care/methods/trends
MH  - Professional-Patient Relations
MH  - Staff Development/methods/trends
MH  - Survivors/psychology
EDAT- 2011/10/13 06:00
MHDA- 2012/02/15 06:00
CRDT- 2011/10/13 06:00
PHST- 2011/10/13 06:00 [entrez]
PHST- 2011/10/13 06:00 [pubmed]
PHST- 2012/02/15 06:00 [medline]
AID - 10.1097/HPC.0b013e318223c3bc [doi]
AID - 00132577-201106000-00011 [pii]
PST - ppublish
SO  - Crit Pathw Cardiol. 2011 Jun;10(2):113-4. doi: 10.1097/HPC.0b013e318223c3bc.


PMID- 21988579
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20111012
IS  - 1099-9809 (Print)
IS  - 1077-341X (Linking)
VI  - 17
IP  - 4
DP  - 2011 Oct
TI  - Understanding what students bring to the classroom: moderators of the effects of 
      diversity courses on student attitudes.
PG  - 397-405
LID - 10.1037/a0025433 [doi]
AB  - We investigated the impact of required diversity courses on students'
      understanding of racial inequality and their social development with regard to
      racial outgroups, with a specific focus on the effects of student race and
      empathy as moderators of diversity course effectiveness. First-semester students 
      (N = 173), enrolled in either diversity courses or introduction to psychology,
      completed surveys at the beginning and end of the semester. Diversity courses
      increased understanding of White privilege, acknowledgment of blatant racism, and
      intersectional consciousness overall, but had a greater impact on intersectional 
      consciousness for White students compared with students of color. White students 
      taking diversity courses experienced a reduction in Protestant work ethic
      ideology that was absent for White students in psychology courses and for all
      students of color. Notably, empathy moderated the effect of diversity courses on 
      both outgroup comfort and willingness to act to promote diversity.
FAU - Cole, Elizabeth R
AU  - Cole ER
AD  - University of Michigan, Women's Studies Department, Ann Harbor, MI 48109-1290,
      USA. ecole@umich.edu
FAU - Case, Kim A
AU  - Case KA
FAU - Rios, Desdamona
AU  - Rios D
FAU - Curtin, Nicola
AU  - Curtin N
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cultur Divers Ethnic Minor Psychol
JT  - Cultural diversity & ethnic minority psychology
JID - 100956435
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Comprehension
MH  - *Cultural Diversity
MH  - Curriculum
MH  - Empathy
MH  - Female
MH  - Humans
MH  - Male
MH  - Michigan
MH  - Minority Groups/*psychology
MH  - *Prejudice
MH  - Race Relations
MH  - Students/*psychology
MH  - Teaching/methods
MH  - Universities
MH  - Young Adult
EDAT- 2011/10/13 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/10/13 06:00
PHST- 2011/10/13 06:00 [entrez]
PHST- 2011/10/13 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 2011-23166-005 [pii]
AID - 10.1037/a0025433 [doi]
PST - ppublish
SO  - Cultur Divers Ethnic Minor Psychol. 2011 Oct;17(4):397-405. doi:
      10.1037/a0025433.


PMID- 21988445
OWN - NLM
STAT- MEDLINE
DCOM- 20120213
LR  - 20111012
IS  - 1365-2834 (Electronic)
IS  - 0966-0429 (Linking)
VI  - 19
IP  - 7
DP  - 2011 Oct
TI  - Implications for nurse managers arising from immigrant women's experience of
      midwifery care in a hospital.
PG  - 967-75
LID - 10.1111/j.1365-2834.2011.01310.x [doi]
AB  - AIM: This paper focuses on implications for nurse managers to support midwives in
      delivering nursing care to immigrant mothers in some government hospitals in
      Gauteng, South Africa. BACKGROUND: Immigration and poverty in Africa has led to
      midwives providing nursing care to immigrant mothers in a culturally sensitive
      environment. This necessitates an environment in which nurse managers should
      support midwives in caring for these mothers as unique individuals. METHOD: An
      exploratory, descriptive phenomenological design was followed. The target
      population included nine immigrant mothers living in the inner centre of
      Johannesburg who, for the first time, attended, had antenatal clinics, laboured
      and gave birth at a Government Hospital in the Gauteng province of South Africa. 
      After purposive sampling, phenomenological interviews were conducted until data
      saturation occurred. RESULTS: The findings indicate that nurse managers should
      ensure that midwifery care of immigrant mothers comply with the ethical-legal
      context of the South African constitution. Actions should be taken in combating
      issues related to impaired maternal-midwife relationship, lack of cultural
      sensitivity and psychological distress. CONCLUSION: The delivery of maternity
      care to immigrant mothers is below the standard expected in the South African
      context. IMPLICATIONS FOR NURSING MANAGEMENT: The nurse manager should support
      midwives to ensure an environment to care for immigrant mothers in maternity
      wards.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Tebid, Roseline
AU  - Tebid R
AD  - Department of Nursing, Faculty of Health Sciences, University of Johannesburg,
      Johannesburg, South Africa.
FAU - Du Plessis, Diana
AU  - Du Plessis D
FAU - Beukes, Sonya
AU  - Beukes S
FAU - van Niekerk, Vasti
AU  - van Niekerk V
FAU - Jooste, Karien
AU  - Jooste K
LA  - eng
PT  - Journal Article
DEP - 20110930
PL  - England
TA  - J Nurs Manag
JT  - Journal of nursing management
JID - 9306050
MH  - Attitude to Health
MH  - Cultural Competency
MH  - Emigrants and Immigrants/*psychology
MH  - Female
MH  - Hospitals, Public/organization & administration/standards
MH  - Humans
MH  - Maternal Health Services/*organization & administration/standards
MH  - Midwifery/*organization & administration/standards
MH  - *Nurse Administrators
MH  - *Nurse-Patient Relations
MH  - Nursing Evaluation Research
MH  - Pregnancy
MH  - Prenatal Care/organization & administration/standards
MH  - Qualitative Research
MH  - South Africa
MH  - Stress, Psychological
EDAT- 2011/10/13 06:00
MHDA- 2012/02/14 06:00
CRDT- 2011/10/13 06:00
PHST- 2011/10/13 06:00 [entrez]
PHST- 2011/10/13 06:00 [pubmed]
PHST- 2012/02/14 06:00 [medline]
AID - 10.1111/j.1365-2834.2011.01310.x [doi]
PST - ppublish
SO  - J Nurs Manag. 2011 Oct;19(7):967-75. doi: 10.1111/j.1365-2834.2011.01310.x. Epub 
      2011 Sep 30.


PMID- 21988436
OWN - NLM
STAT- MEDLINE
DCOM- 20120213
LR  - 20151119
IS  - 1365-2834 (Electronic)
IS  - 0966-0429 (Linking)
VI  - 19
IP  - 7
DP  - 2011 Oct
TI  - Individuality in older people's care - challenges for the development of nursing 
      and nursing management.
PG  - 883-96
LID - 10.1111/j.1365-2834.2011.01243.x [doi]
AB  - AIM: To explore nurses' perceptions about individuality in older people's care.
      BACKGROUND: Individualized care is enshrined in health-care policies and ethical 
      and quality guidelines concerning older peoples' care but assessments of
      individualized care delivery are limited. METHODS: Using a descriptive survey
      design, Individualized Care Scale questionnaires (n = 147) were used to collect
      data from 96 registered or licensed practical nurses (response 65%) working in
      the inpatient wards of four randomly selected long-term care hospitals in 2008.
      The questionnaires were analysed statistically. RESULTS: Nurses perceived that
      they supported older patients' individuality well in the clinical situation and
      maintained patients' decisional control over their care. Nurses also perceived
      that although they moderately supported their patients' personal life situation
      they did not actively encourage patients' families to take part in care.
      CONCLUSIONS: This study revealed some shortcomings in the maintenance of
      individuality in older peoples' care and the need to change the focus of care
      from reactive management to a proactive prevention orientation to improve the
      well-being of older people. IMPLICATIONS FOR NURSING MANAGEMENT: There is a need 
      to examine the care structures and processes and the role of nurse professionals 
      in older peoples' care under the guidance of nurse leaders and managers.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Suhonen, Riitta
AU  - Suhonen R
AD  - Department of Nursing Science, University of Turku, Turku, Finland. riisuh@utu.fi
FAU - Stolt, Minna
AU  - Stolt M
FAU - Puro, Markku
AU  - Puro M
FAU - Leino-Kilpi, Helena
AU  - Leino-Kilpi H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110706
PL  - England
TA  - J Nurs Manag
JT  - Journal of nursing management
JID - 9306050
MH  - Adult
MH  - Aged
MH  - *Attitude of Health Personnel
MH  - Female
MH  - Finland
MH  - Geriatric Nursing/*organization & administration
MH  - Humans
MH  - Long-Term Care/organization & administration
MH  - Male
MH  - Middle Aged
MH  - *Nurse-Patient Relations
MH  - Nursing Methodology Research
MH  - Nursing Staff, Hospital/*psychology
MH  - Patient Participation
MH  - Precision Medicine/*nursing
MH  - Young Adult
EDAT- 2011/10/13 06:00
MHDA- 2012/02/14 06:00
CRDT- 2011/10/13 06:00
PHST- 2011/10/13 06:00 [entrez]
PHST- 2011/10/13 06:00 [pubmed]
PHST- 2012/02/14 06:00 [medline]
AID - 10.1111/j.1365-2834.2011.01243.x [doi]
PST - ppublish
SO  - J Nurs Manag. 2011 Oct;19(7):883-96. doi: 10.1111/j.1365-2834.2011.01243.x. Epub 
      2011 Jul 6.


PMID- 21988262
OWN - NLM
STAT- MEDLINE
DCOM- 20111215
LR  - 20111221
IS  - 1749-6632 (Electronic)
IS  - 0077-8923 (Linking)
VI  - 1234
DP  - 2011 Oct
TI  - Self-knowledge and the practice of ethics: Ostad Elahi's concept of the
      "imperious self".
PG  - 149-57
LID - 10.1111/j.1749-6632.2011.06203.x [doi]
AB  - When approaching the perplexing issue of self-knowledge, two questions should be 
      kept in mind: What type of knowledge do we expect? and, more importantly, Why
      does this knowledge matter for us? Among the motivations behind such an endeavor,
      the ethical project of self-transformation is of particular interest, for it
      sheds light on the inherently constructive nature of self-knowledge.
      Psychologists dealing with the issue of self-realization and identity formation, 
      however, generally tend to overlook the resources offered by ethics considered as
      a genuine self-transformative practice (in contrast to morality as a set of rules
      or principles to be applied in specific contexts). The tradition of "spiritual
      exercises" is considered from this self-transformative perspective, as well as
      Plato's conception of self-knowledge ("know thyself"). Finally, Ostad Elahi's
      concept of the "imperious self" is examined in detail: beyond the particular
      context to which it belongs (spiritual ethics), the "imperious self" appears as a
      valuable tool for understanding the active part played by self-modeling in the
      process of self-transformation.
CI  - (c) 2011 New York Academy of Sciences.
FAU - During, Elie
AU  - During E
AD  - Department of Philosophy, University of Paris Ouest-Nanterre La Defense, Paris,
      France. during@ens.fr
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
SB  - IM
MH  - Humans
MH  - Knowledge
MH  - Psychology/*ethics
MH  - *Self Concept
MH  - Self Disclosure
EDAT- 2011/10/13 06:00
MHDA- 2011/12/16 06:00
CRDT- 2011/10/13 06:00
PHST- 2011/10/13 06:00 [entrez]
PHST- 2011/10/13 06:00 [pubmed]
PHST- 2011/12/16 06:00 [medline]
AID - 10.1111/j.1749-6632.2011.06203.x [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2011 Oct;1234:149-57. doi: 10.1111/j.1749-6632.2011.06203.x.


PMID- 21988261
OWN - NLM
STAT- MEDLINE
DCOM- 20111215
LR  - 20111221
IS  - 1749-6632 (Electronic)
IS  - 0077-8923 (Linking)
VI  - 1234
DP  - 2011 Oct
TI  - Who am I? Beyond "I think, therefore I am".
PG  - 134-48
LID - 10.1111/j.1749-6632.2011.06186.x [doi]
AB  - Can we ever truly answer the question, "Who am I?" Moderated by Alex Voorhoeve
      (London School of Economics), neuro-philosopher Elie During (University of Paris,
      Ouest Nanterre), cognitive scientist David Jopling (York University, Canada),
      social psychologist Timothy Wilson (University of Virginia), and ethicist Frances
      Kamm (Harvard University) examine the difficulty of achieving genuine
      self-knowledge and how the pursuit of self-knowledge plays a role in shaping the 
      self.
CI  - (c) 2011 New York Academy of Sciences.
FAU - Voorhoeve, Alex
AU  - Voorhoeve A
FAU - During, Elie
AU  - During E
FAU - Jopling, David
AU  - Jopling D
FAU - Wilson, Timothy
AU  - Wilson T
FAU - Kamm, Frances
AU  - Kamm F
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
SB  - IM
MH  - Humans
MH  - Knowledge
MH  - Philosophy
MH  - Psychology, Social
MH  - *Self Concept
EDAT- 2011/10/13 06:00
MHDA- 2011/12/16 06:00
CRDT- 2011/10/13 06:00
PHST- 2011/10/13 06:00 [entrez]
PHST- 2011/10/13 06:00 [pubmed]
PHST- 2011/12/16 06:00 [medline]
AID - 10.1111/j.1749-6632.2011.06186.x [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2011 Oct;1234:134-48. doi: 10.1111/j.1749-6632.2011.06186.x.


PMID- 21988018
OWN - NLM
STAT- MEDLINE
DCOM- 20111103
LR  - 20181201
IS  - 1320-159X (Print)
IS  - 1320-159X (Linking)
VI  - 19
IP  - 1
DP  - 2011 Sep
TI  - Young children as regenerative tissue donors: considering the need for legal
      reform in light of divergent ethical approaches.
PG  - 172-95
AB  - In Australia, young children who lack decision-making capacity can have
      regenerative tissue removed to treat another person suffering from a severe or
      life-threatening disease. While great good can potentially result from this as
      the recipient's life may be saved, ethical unease remains over the "use" of young
      children in this way. This article examines the ethical approaches that have
      featured in the debate over the acceptability and limits of this practice, and
      how these are reflected in Australia's legal regime governing removal of tissue
      from young children. This analysis demonstrates a troubling dichotomy within
      Australia's laws that requires decision-makers to adopt inconsistent ethical
      approaches depending on where a donor child is situated. It is argued that this
      inconsistency in approach warrants legal reform of this ethically sensitive
      issue.
FAU - Then, Shih-Ning
AU  - Then SN
AD  - Law Faculty, Queensland University of Technology. Shih-Ning.Then@qut.edu.au
LA  - eng
PT  - Journal Article
PT  - Legal Case
PL  - Australia
TA  - J Law Med
JT  - Journal of law and medicine
JID - 9431853
SB  - IM
MH  - Australia
MH  - Child
MH  - Child Welfare/legislation & jurisprudence
MH  - Humans
MH  - Informed Consent/*legislation & jurisprudence
MH  - Living Donors/ethics/*legislation & jurisprudence
MH  - Personal Autonomy
MH  - Tissue Donors/ethics/*legislation & jurisprudence
EDAT- 2011/10/13 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/10/13 06:00
PHST- 2011/10/13 06:00 [entrez]
PHST- 2011/10/13 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
PST - ppublish
SO  - J Law Med. 2011 Sep;19(1):172-95.


PMID- 21988017
OWN - NLM
STAT- MEDLINE
DCOM- 20111103
LR  - 20111012
IS  - 1320-159X (Print)
IS  - 1320-159X (Linking)
VI  - 19
IP  - 1
DP  - 2011 Sep
TI  - The ethical obligations of the military medical practitioner.
PG  - 155-71
AB  - International humanitarian law requires medical practitioners to be given
      "respect and protection" when serving as medical practitioners in the military. A
      component of this legal assurance is that when military medical personnel base
      their decisions on their medical code of ethics, that decision will be respected 
      and protected. Although the "respect" that has been afforded by international
      humanitarian law has been part of the law for a considerable period of time, it
      is not always clear that military command or the courts are sufficiently aware of
      the ambit of this prescription.
FAU - Niemann, Grant
AU  - Niemann G
AD  - School of Law, Flinders University South Australia. grant.niemann@flinders.edu.au
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Law Med
JT  - Journal of law and medicine
JID - 9431853
SB  - IM
MH  - Codes of Ethics
MH  - Humans
MH  - Internationality/legislation & jurisprudence
MH  - *Military Personnel
MH  - Physicians/*ethics
EDAT- 2011/10/13 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/10/13 06:00
PHST- 2011/10/13 06:00 [entrez]
PHST- 2011/10/13 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
PST - ppublish
SO  - J Law Med. 2011 Sep;19(1):155-71.


PMID- 21987976
OWN - NLM
STAT- MEDLINE
DCOM- 20111123
LR  - 20161125
IS  - 2046-2336 (Print)
IS  - 2046-2336 (Linking)
VI  - 23
IP  - 7
DP  - 2011 Sep
TI  - Confidentiality: the legal issues.
PG  - 18-9
AB  - In children's nursing confidentiality is a principle that combines legal
      obligations and ethical standards. This article outlines how this principle
      applies to nurses in the course of their professional duties with children, young
      people and their parents and carers. There is also a discussion about 'Gillick
      competence' and exceptions where a nurse is obligated to breach confidentiality, 
      such as in cases of suspected child abuse.
FAU - Cornock, Marc
AU  - Cornock M
AD  - School of Law, The Open University, Milton Keynes.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Child Young People
JT  - Nursing children and young people
JID - 101554473
MH  - Adolescent
MH  - Child
MH  - Confidentiality/ethics/*legislation & jurisprudence
MH  - Humans
MH  - Minors/*legislation & jurisprudence
MH  - United Kingdom
EDAT- 2011/10/13 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/10/13 06:00
PHST- 2011/10/13 06:00 [entrez]
PHST- 2011/10/13 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.7748/ncyp2011.09.23.7.18.c8682 [doi]
PST - ppublish
SO  - Nurs Child Young People. 2011 Sep;23(7):18-9. doi:
      10.7748/ncyp2011.09.23.7.18.c8682.


PMID- 21986999
OWN - NLM
STAT- MEDLINE
DCOM- 20120815
LR  - 20211020
IS  - 1938-744X (Electronic)
IS  - 1935-7893 (Linking)
VI  - 5
IP  - 3
DP  - 2011 Oct
TI  - Literature review and global consensus on management of acute radiation syndrome 
      affecting nonhematopoietic organ systems.
PG  - 183-201
LID - 10.1001/dmp.2011.73 [doi]
AB  - OBJECTIVES: The World Health Organization convened a panel of experts to rank the
      evidence for medical countermeasures for management of acute radiation syndrome
      (ARS) in a hypothetical scenario involving the hospitalization of 100 to 200
      victims. The goal of this panel was to achieve consensus on optimal management of
      ARS affecting nonhematopoietic organ systems based upon evidence in the published
      literature. METHODS: English-language articles were identified in MEDLINE and
      PubMed. Reference lists of retrieved articles were distributed to conferees in
      advance of and updated during the meeting. Published case series and case reports
      of ARS, publications of randomized controlled trials of relevant interventions
      used to treat nonirradiated individuals, reports of studies in irradiated
      animals, and prior recommendations of subject matter experts were selected.
      Studies were extracted using the Grading of Recommendations Assessment
      Development and Evaluation system. In cases in which data were limited or
      incomplete, a narrative review of the observations was made. RESULTS: No
      randomized controlled trials of medical countermeasures have been completed for
      individuals with ARS. Reports of countermeasures were often incompletely
      described, making it necessary to rely on data generated in nonirradiated humans 
      and in experimental animals. A strong recommendation is made for the
      administration of a serotonin-receptor antagonist prophylactically when the
      suspected exposure is >2 Gy and topical steroids, antibiotics, and antihistamines
      for radiation burns, ulcers, or blisters; excision and grafting of radiation
      ulcers or necrosis with intractable pain; provision of supportive care to
      individuals with neurovascular syndrome; and administration of electrolyte
      replacement therapy and sedatives to individuals with significant burns,
      hypovolemia, and/or shock. A strong recommendation is made against the use of
      systemic steroids in the absence of a specific indication. A weak recommendation 
      is made for the use of fluoroquinolones, bowel decontamination, loperamide, and
      enteral nutrition, and for selective oropharyngeal/digestive decontamination,
      blood glucose maintenance, and stress ulcer prophylaxis in critically ill
      patients. CONCLUSIONS: High-quality studies of therapeutic interventions in
      humans exposed to nontherapeutic radiation are not available, and because of
      ethical concerns regarding the conduct of controlled studies in humans, such
      studies are unlikely to emerge in the near future.
FAU - Dainiak, Nicholas
AU  - Dainiak N
AD  - Yale University School of Medicine and Yale-New Haven Health-Bridgeport Hospital,
      USA.
FAU - Gent, Robert Nicolas
AU  - Gent RN
FAU - Carr, Zhanat
AU  - Carr Z
FAU - Schneider, Rita
AU  - Schneider R
FAU - Bader, Judith
AU  - Bader J
FAU - Buglova, Elena
AU  - Buglova E
FAU - Chao, Nelson
AU  - Chao N
FAU - Coleman, C Norman
AU  - Coleman CN
FAU - Ganser, Arnold
AU  - Ganser A
FAU - Gorin, Claude
AU  - Gorin C
FAU - Hauer-Jensen, Martin
AU  - Hauer-Jensen M
FAU - Huff, L Andrew
AU  - Huff LA
FAU - Lillis-Hearne, Patricia
AU  - Lillis-Hearne P
FAU - Maekawa, Kazuhiko
AU  - Maekawa K
FAU - Nemhauser, Jeffrey
AU  - Nemhauser J
FAU - Powles, Ray
AU  - Powles R
FAU - Schunemann, Holger
AU  - Schunemann H
FAU - Shapiro, Alla
AU  - Shapiro A
FAU - Stenke, Leif
AU  - Stenke L
FAU - Valverde, Nelson
AU  - Valverde N
FAU - Weinstock, David
AU  - Weinstock D
FAU - White, Douglas
AU  - White D
FAU - Albanese, Joseph
AU  - Albanese J
FAU - Meineke, Viktor
AU  - Meineke V
LA  - eng
GR  - U19 AI067798/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20111010
PL  - United States
TA  - Disaster Med Public Health Prep
JT  - Disaster medicine and public health preparedness
JID - 101297401
SB  - IM
CIN - Disaster Med Public Health Prep. 2011 Oct;5(3):180-2. PMID: 22003138
MH  - Acute Radiation Syndrome/*therapy
MH  - Consensus Development Conferences as Topic
MH  - Critical Illness/*therapy
MH  - Expert Testimony
MH  - Humans
MH  - Skin/*radiation effects
MH  - Skin Diseases/*etiology
MH  - United States
MH  - World Health Organization
PMC - PMC3638239
MID - NIHMS458608
EDAT- 2011/10/12 06:00
MHDA- 2012/08/16 06:00
CRDT- 2011/10/12 06:00
PHST- 2011/10/12 06:00 [entrez]
PHST- 2011/10/12 06:00 [pubmed]
PHST- 2012/08/16 06:00 [medline]
AID - 10.1001/dmp.2011.73 [doi]
PST - ppublish
SO  - Disaster Med Public Health Prep. 2011 Oct;5(3):183-201. doi: 10.1001/dmp.2011.73.
      Epub 2011 Oct 10.


PMID- 21986969
OWN - NLM
STAT- MEDLINE
DCOM- 20120208
LR  - 20151119
IS  - 1932-8095 (Electronic)
IS  - 1932-8087 (Linking)
VI  - 16
IP  - 6
DP  - 2011 Nov-Dec
TI  - The 6 dimensions of promising practice for case managed supports to end
      homelessness, part 1: contextualizing case management for ending homelessness.
PG  - 281-7; quiz 288-9
LID - 10.1097/NCM.0b013e31821ee840 [doi]
AB  - PURPOSE/OBJECTIVES: Homelessness is a social condition increasing in frequency
      and severity across Canada. Interventions to end and prevent homelessness include
      effective case management in addition to an affordable housing provision. Little 
      standardization exists for service providers to guide their decision making in
      developing and maintaining effective case management programs. The purpose of
      this 2-part article is to articulate dimensions of promising practice for case
      managers working in a "Housing First" context. Part 1 discusses research
      processes and findings and part-2 articulates the 6 Dimensions of Quality.
      PRIMARY PRACTICE SETTING: Practice settings include community-based organizations
      that employ and support case managers whose primary role is moving people from
      homelessness into permanent housing. FINDINGS/CONCLUSIONS: Six dimensions of
      promising practice are critically important to reducing barriers, improving
      sector collaboration, and ensuring case managers have appropriate and effective
      training and support. Dimensions of promising practice are: (1) collaboration and
      cooperation-a true team approach; (2) right matching of services-person-centered;
      (3) contextual case management-culture and flexibility; (4) the right kind of
      engagement-relationships and advocacy; (5) coordinated and well managed
      system-ethics and communication; and (6) evaluation for success-support and
      training. IMPLICATIONS FOR CASE MANAGEMENT PRACTICE: Effective, coordinated case 
      management, in addition to permanent affordable housing has the potential to
      reduce a person or family's homelessness permanently. Organizations and
      professionals working in this context have the opportunity to improve processes, 
      reduce burnout, collaborate and standardize, and most importantly, efficiently
      and permanently end someone's homelessness with the help of dimensions of quality
      for case management.
FAU - Milaney, Katrina
AU  - Milaney K
AD  - Calgary Homeless Foundation, AB, Canada. kmilaney@calgaryhomeless.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Prof Case Manag
JT  - Professional case management
JID - 101291585
MH  - Canada
MH  - *Case Management
MH  - *Community Health Services
MH  - Concept Formation
MH  - *Continuity of Patient Care
MH  - Cooperative Behavior
MH  - Decision Making
MH  - *Homeless Persons
MH  - Housing/statistics & numerical data
MH  - Humans
MH  - Models, Organizational
MH  - Practice Patterns, Physicians'/*statistics & numerical data
MH  - Program Development/*methods
MH  - Program Evaluation
EDAT- 2011/10/12 06:00
MHDA- 2012/02/09 06:00
CRDT- 2011/10/12 06:00
PHST- 2011/10/12 06:00 [entrez]
PHST- 2011/10/12 06:00 [pubmed]
PHST- 2012/02/09 06:00 [medline]
AID - 10.1097/NCM.0b013e31821ee840 [doi]
AID - 01269241-201111000-00004 [pii]
PST - ppublish
SO  - Prof Case Manag. 2011 Nov-Dec;16(6):281-7; quiz 288-9. doi:
      10.1097/NCM.0b013e31821ee840.


PMID- 21986461
OWN - NLM
STAT- MEDLINE
DCOM- 20120320
LR  - 20211020
IS  - 1531-7072 (Electronic)
IS  - 1070-5295 (Linking)
VI  - 17
IP  - 6
DP  - 2011 Dec
TI  - ICU capacity strain and the quality and allocation of critical care.
PG  - 648-57
LID - 10.1097/MCC.0b013e32834c7a53 [doi]
AB  - PURPOSE OF REVIEW: Increasing demand for critical care, with limited potential
      for comparable expansion of supply, may strain the abilities of ICUs to provide
      high-quality care in an equitable fashion. Efforts to counter the untoward
      consequences for the quality and ethics of critical care delivery are limited by 
      the absence of a specific and validated metric of ICU capacity strain. RECENT
      FINDINGS: This manuscript presents a conceptual framework for ICU capacity
      strain, considers what data elements may contribute to it, and suggests methods
      for determining the optimal metric. Next, it outlines the range of potential
      consequences of increased capacity strain, in terms of both the quality and
      ethics of care delivered. Finally, consideration is given to how untoward
      consequences of ICU capacity strain might be mitigated through better
      understanding of what makes some ICUs better able than others to withstand
      temporal fluctuations in the demand for their services. SUMMARY: Development of
      an appropriately accurate and parsimonious measure of ICU capacity strain may
      augment the precision of future critical care outcomes research by reducing
      unexplained variance attributable to temporal fluctuations in ICU-level factors; 
      elucidate organizational characteristics that make some ICUs better able to
      withstand high-capacity strain without substantive degradations in quality; and
      enhance the transparency of critical care rationing while helping to improve its 
      equity and efficiency, thereby promoting the ethics of this inevitable practice.
FAU - Halpern, Scott D
AU  - Halpern SD
AD  - Division of Pulmonary, Allergy, and Critical Care Medicine, Perelman School of
      Medicine, University of Pennsylvania, Pennsylvania, Philadelphia, USA.
      shalpern@exchange.upenn.edu
LA  - eng
GR  - K08 HS018406/HS/AHRQ HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Curr Opin Crit Care
JT  - Current opinion in critical care
JID - 9504454
SB  - IM
MH  - Concept Formation
MH  - Delivery of Health Care/methods/organization & administration
MH  - *Ethics, Medical
MH  - *Health Services Accessibility
MH  - *Health Services Needs and Demand
MH  - *Hospital Bed Capacity
MH  - Humans
MH  - Intensive Care Units/ethics/*organization & administration
MH  - Length of Stay
MH  - Models, Organizational
MH  - Quality Improvement
MH  - *Quality of Health Care
MH  - United States
EDAT- 2011/10/12 06:00
MHDA- 2012/03/21 06:00
CRDT- 2011/10/12 06:00
PHST- 2011/10/12 06:00 [entrez]
PHST- 2011/10/12 06:00 [pubmed]
PHST- 2012/03/21 06:00 [medline]
AID - 10.1097/MCC.0b013e32834c7a53 [doi]
PST - ppublish
SO  - Curr Opin Crit Care. 2011 Dec;17(6):648-57. doi: 10.1097/MCC.0b013e32834c7a53.


PMID- 21986412
OWN - NLM
STAT- MEDLINE
DCOM- 20111121
LR  - 20160519
IS  - 1878-8769 (Electronic)
IS  - 1878-8750 (Linking)
VI  - 76
IP  - 3-4
DP  - 2011 Sep-Oct
TI  - Statement of Ethics in Neurosurgery of the World Federation of Neurosurgical
      Societies.
PG  - 239-47
LID - 10.1016/j.wneu.2011.06.001 [doi]
AB  - This Statement of Ethics in Neurosurgery was developed by the Committee for
      Ethics and Medico-Legal Affairs of the World Federation of Neurosurgical
      Societies to help neurosurgeons resolve problems in the treatment of individual
      patients and meet obligations to the larger society. This document is intended as
      a framework rather than a set of rules. It cannot cover every situation and
      should be used with flexibility. However, it is our intent that the fundamental
      principles enunciated here should serve as a guide in the day-to-day practice of 
      neurosurgery.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Umansky, Felix
AU  - Umansky F
AD  - Department of Neurosurgery, Hadassah-Hebrew University Medical Center, Jerusalem,
      Israel. umansky@hadassah.org.il
FAU - Black, Peter L
AU  - Black PL
FAU - DiRocco, Concenzio
AU  - DiRocco C
FAU - Ferrer, Enrique
AU  - Ferrer E
FAU - Goel, Atul
AU  - Goel A
FAU - Malik, Ghaus M
AU  - Malik GM
FAU - Mathiesen, Tiit
AU  - Mathiesen T
FAU - Mendez, Ivar
AU  - Mendez I
FAU - Palmer, James D
AU  - Palmer JD
FAU - Juanotena, Jorge Rodriguez
AU  - Juanotena JR
FAU - Fraifeld, Shifra
AU  - Fraifeld S
FAU - Rosenfeld, Jeffrey V
AU  - Rosenfeld JV
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - World Neurosurg
JT  - World neurosurgery
JID - 101528275
SB  - IM
MH  - Advance Directives/ethics
MH  - Clinical Trials as Topic/ethics
MH  - Communication
MH  - Confidentiality/ethics
MH  - Conflict of Interest
MH  - Ethics, Research
MH  - Evidence-Based Medicine/ethics
MH  - Expert Testimony/ethics
MH  - Humans
MH  - Life Style
MH  - Neurosurgery/*ethics/legislation & jurisprudence/standards
MH  - Neurosurgical Procedures/*ethics/legislation & jurisprudence/standards
MH  - Organ Transplantation/ethics
MH  - Societies, Medical
MH  - Teaching/ethics
MH  - Terminal Care/ethics
MH  - Withholding Treatment/ethics
EDAT- 2011/10/12 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/10/12 06:00
PHST- 2011/05/15 00:00 [received]
PHST- 2011/06/01 00:00 [accepted]
PHST- 2011/10/12 06:00 [entrez]
PHST- 2011/10/12 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S1878-8750(11)00735-2 [pii]
AID - 10.1016/j.wneu.2011.06.001 [doi]
PST - ppublish
SO  - World Neurosurg. 2011 Sep-Oct;76(3-4):239-47. doi: 10.1016/j.wneu.2011.06.001.


PMID- 21986187
OWN - NLM
STAT- MEDLINE
DCOM- 20120517
LR  - 20220321
IS  - 1095-8304 (Electronic)
IS  - 0195-6663 (Linking)
VI  - 58
IP  - 1
DP  - 2012 Feb
TI  - Understanding the motives for food choice in Western Balkan Countries.
PG  - 205-14
LID - 10.1016/j.appet.2011.09.012 [doi]
AB  - Substantial empirical evidence exists regarding the importance of different
      factors underlying food choice in Western Europe. However, research results on
      eating habits and food choice in the Western Balkan Countries (WBCs) remain
      scarce. A Food Choice Questionnaire (FCQ), an instrument that measures the
      reported importance of nine factors underlying food choice, was administered to a
      representative sample of 3085 adult respondents in six WBCs. The most important
      factors reported are sensory appeal, purchase convenience, and health and natural
      content; the least important are ethical concern and familiarity. The ranking of 
      food choice motives across WBCs was strikingly similar. Factor analysis revealed 
      eight factors compared to nine in the original FCQ model: health and natural
      content scales loaded onto one factor as did familiarity and ethical concern; the
      convenience scale items generated two factors, one related to purchase
      convenience and the other to preparation convenience. Groups of consumers with
      similar motivational profiles were identified using cluster analysis. Each
      cluster has distinct food purchasing behavior and socio-economic characteristics,
      for which appropriate public health communication messages can be drawn.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Milosevic, Jasna
AU  - Milosevic J
AD  - IPSOS Strategic Marketing, Gavrila Principa 8, 11000 Belgrade, Serbia.
FAU - Zezelj, Iris
AU  - Zezelj I
FAU - Gorton, Matthew
AU  - Gorton M
FAU - Barjolle, Dominique
AU  - Barjolle D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111001
PL  - England
TA  - Appetite
JT  - Appetite
JID - 8006808
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Choice Behavior
MH  - Cluster Analysis
MH  - Europe
MH  - Factor Analysis, Statistical
MH  - *Feeding Behavior
MH  - Female
MH  - Food/economics
MH  - *Food Preferences
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Middle Aged
MH  - Surveys and Questionnaires
MH  - Taste
MH  - Young Adult
EDAT- 2011/10/12 06:00
MHDA- 2012/05/18 06:00
CRDT- 2011/10/12 06:00
PHST- 2011/06/10 00:00 [received]
PHST- 2011/09/05 00:00 [revised]
PHST- 2011/09/08 00:00 [accepted]
PHST- 2011/10/12 06:00 [entrez]
PHST- 2011/10/12 06:00 [pubmed]
PHST- 2012/05/18 06:00 [medline]
AID - S0195-6663(11)00580-0 [pii]
AID - 10.1016/j.appet.2011.09.012 [doi]
PST - ppublish
SO  - Appetite. 2012 Feb;58(1):205-14. doi: 10.1016/j.appet.2011.09.012. Epub 2011 Oct 
      1.


PMID- 21985808
OWN - NLM
STAT- MEDLINE
DCOM- 20120207
LR  - 20220408
IS  - 0971-5916 (Print)
IS  - 0971-5916 (Linking)
VI  - 134
DP  - 2011 Sep
TI  - Umbilical cord blood: current status & promise for the future.
PG  - 261-9
AB  - Umbilical cord blood (UCB) has been shown to be a suitable source of
      haematopoietic stem cells (HSCs) for haematopoietic reconstitution. An increase
      in the number of UCB transplants indicates an expansion of utility in a broad
      spectrum of disease conditions. Along with the advantages, UCB also has
      limitations, and hence several investigators are working to further optimize UCB 
      for this use. Beyond haematopoietic transplantation, additional potential
      applications of UCB include immunotherapy, tissue engineering and regenerative
      medicine. UCB banking has improved with time largely due to involvement of
      professional organizations and their published standards. However, accreditation 
      of these organizations remains voluntary, and in India three of ten banks are
      public with the remaining being private. Only one public and one private bank are
      American Association of Blood Banks (AABB) accredited in India. Government
      agencies need to provide regulatory and safety oversight, which is lacking in
      serveral countries. Public policy regarding UCB is in its infancy throughout most
      of the world. Ethical issues, including access to UCB banking and use as therapy 
      for diseases other than haematological and metabolic disorders are in the early
      phase of trials and remain speculative.
FAU - McKenna, David
AU  - McKenna D
AD  - Foundation for Research in Genetics & Endocrinology, Ahmedabad, India.
FAU - Sheth, Jayesh
AU  - Sheth J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - India
TA  - Indian J Med Res
JT  - The Indian journal of medical research
JID - 0374701
SB  - IM
MH  - Blood Banks/legislation & jurisprudence/*methods/standards/statistics & numerical
      data
MH  - Cord Blood Stem Cell Transplantation/statistics & numerical data/*trends
MH  - Fetal Blood/*cytology
MH  - *Hematopoietic Stem Cells
MH  - Humans
MH  - India
PMC - PMC3193706
EDAT- 2011/10/12 06:00
MHDA- 2012/02/09 06:00
CRDT- 2011/10/12 06:00
PHST- 2011/10/12 06:00 [entrez]
PHST- 2011/10/12 06:00 [pubmed]
PHST- 2012/02/09 06:00 [medline]
AID - IndianJMedRes_2011_134_3_261_85546 [pii]
PST - ppublish
SO  - Indian J Med Res. 2011 Sep;134:261-9.


PMID- 21985759
OWN - NLM
STAT- MEDLINE
DCOM- 20120403
LR  - 20131121
IS  - 1532-2777 (Electronic)
IS  - 0306-9877 (Linking)
VI  - 78
IP  - 1
DP  - 2012 Jan
TI  - Does light alcohol consumption during pregnancy improve offspring's cognitive
      development?
PG  - 69-70
LID - 10.1016/j.mehy.2011.09.043 [doi]
AB  - We posit that: (i) light alcohol consumption during pregnancy does not improve
      the cognitive development of human offspring and (ii) observational study
      outcomes indicating apparent protective effects arise from residual confounding
      due to socioeconomic status. Our hypotheses counter emerging hypotheses apparent 
      in the epidemiological literature that light alcohol consumption during pregnancy
      improves offspring's cognitive development. Determining the plausibility of this 
      proposition is important given its potential to influence women's alcohol
      consumption behavior during pregnancy. However, given ethical concerns, it is
      unlikely that a randomized control trial will be conducted to test this
      hypothesis. The veracity of alcohol's purported positive effect on cognitive
      development is therefore explored here by comparing research evidence on light
      alcohol consumption to the evidence for folate and DHA supplementation intake
      during pregnancy. An alternative approach for further testing this hypothesis in 
      observational studies is also suggested.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Liang, Wenbin
AU  - Liang W
AD  - National Drug Research Institute, Curtin University, Perth, Western Australia,
      Australia. w.liang@curtin.edu.au
FAU - Chikritzhs, Tanya
AU  - Chikritzhs T
LA  - eng
PT  - Journal Article
DEP - 20111008
PL  - United States
TA  - Med Hypotheses
JT  - Medical hypotheses
JID - 7505668
RN  - 25167-62-8 (Docosahexaenoic Acids)
RN  - 3K9958V90M (Ethanol)
RN  - 935E97BOY8 (Folic Acid)
SB  - IM
MH  - *Alcohol Drinking
MH  - Cognition/*drug effects
MH  - Docosahexaenoic Acids/pharmacology
MH  - Ethanol/*pharmacology
MH  - Female
MH  - Fetal Development/*drug effects
MH  - Folic Acid/pharmacology
MH  - Humans
MH  - *Models, Biological
MH  - Pregnancy
MH  - Socioeconomic Factors
EDAT- 2011/10/12 06:00
MHDA- 2012/04/04 06:00
CRDT- 2011/10/12 06:00
PHST- 2011/02/23 00:00 [received]
PHST- 2011/09/19 00:00 [revised]
PHST- 2011/09/20 00:00 [accepted]
PHST- 2011/10/12 06:00 [entrez]
PHST- 2011/10/12 06:00 [pubmed]
PHST- 2012/04/04 06:00 [medline]
AID - S0306-9877(11)00496-8 [pii]
AID - 10.1016/j.mehy.2011.09.043 [doi]
PST - ppublish
SO  - Med Hypotheses. 2012 Jan;78(1):69-70. doi: 10.1016/j.mehy.2011.09.043. Epub 2011 
      Oct 8.


PMID- 21985746
OWN - NLM
STAT- MEDLINE
DCOM- 20120224
LR  - 20220129
IS  - 1472-6831 (Electronic)
IS  - 1472-6831 (Linking)
VI  - 11
DP  - 2011 Oct 10
TI  - Protocol for Northern Ireland Caries Prevention in Practice Trial (NIC-PIP)
      trial: a randomised controlled trial to measure the effects and costs of a dental
      caries prevention regime for young children attending primary care dental
      services.
PG  - 27
LID - 10.1186/1472-6831-11-27 [doi]
AB  - BACKGROUND: Dental caries is a persistent public health problem with little
      change in the prevalence in young children over the last 20 years. Once a child
      contracts the disease it has a significant impact on their quality of life. There
      is good evidence from Cochrane reviews including trials that fluoride varnish and
      regular use of fluoride toothpaste can prevent caries. The Northern Ireland
      Caries Prevention in Practice Trial (NIC-PIP) trial will compare the costs and
      effects of a caries preventive package (fluoride varnish, toothpaste, toothbrush 
      and standardised dental health education) with dental health education alone in
      young children. METHODS/DESIGN: A randomised controlled trial on children
      initially aged 2 and 3 years old who are regular attenders at the primary dental 
      care services in Northern Ireland. Children will be recruited and randomised in
      dental practices. Children will be randomised to the prevention package of both
      fluoride varnish (twice per year for three years), fluoride toothpaste (1,450 ppm
      F) (supplied twice per year), a toothbrush (supplied twice a year) or not; both
      test and control groups receive standardised dental health education delivered by
      the dentist twice per year. Randomisation will be conducted by the Belfast Trust 
      Clinical Research Support Centre ([CRSC] a Clinical Trials Unit). 1200
      participants will be recruited from approximately 40 dental practices. Children
      will be examined for caries by independent dental examiners at baseline and will 
      be excluded if they have caries. The independent dental examiners will examine
      the children again at 3 years blinded to study group.The primary end-point is
      whether the child develops caries (cavitation into dentine) or not over the three
      years. One secondary outcome is the number of carious surfaces in the primary
      dentition in children who experience caries. Other secondary outcomes are
      episodes of pain, extraction of primary teeth, other adverse events and costs
      which will be obtained from parental questionnaires. DISCUSSION: This is a
      pragmatic trial conducted in general dental practice. It tests a composite caries
      prevention intervention, which represents an evidence based approach advocated by
      current guidance from the English Department of Health which is feasible to
      deliver to all low risk (caries free) children in general dental practice. The
      trial will provide valuable information to policy makers and clinicians on the
      costs and effects of caries prevention delivered to young children in general
      dental practice. TRIAL REGISTRATION: EudraCT No: 2009 - 010725 - 39 ISRCTN:
      ISRCTN36180119 Ethics Reference No: 09/H1008/93:
FAU - Tickle, Martin
AU  - Tickle M
AD  - School of Dentistry, the University of Manchester, Oxford Road, Manchester, M13
      9PL, UK.
FAU - Milsom, Keith M
AU  - Milsom KM
FAU - Donaldson, Michael
AU  - Donaldson M
FAU - Killough, Seamus
AU  - Killough S
FAU - O'Neill, Ciaran
AU  - O'Neill C
FAU - Crealey, Grainne
AU  - Crealey G
FAU - Sutton, Matthew
AU  - Sutton M
FAU - Noble, Solveig
AU  - Noble S
FAU - Greer, Margaret
AU  - Greer M
FAU - Worthington, Helen V
AU  - Worthington HV
LA  - eng
SI  - ISRCTN/ISRCTN36180119
GR  - 08/14/19/DH_/Department of Health/United Kingdom
GR  - HTA/08/14/19/DH_/Department of Health/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20111010
PL  - England
TA  - BMC Oral Health
JT  - BMC oral health
JID - 101088684
RN  - 0 (Cariostatic Agents)
RN  - 0 (Fluorides, Topical)
RN  - 0 (Toothpastes)
SB  - IM
MH  - Cariostatic Agents/economics/therapeutic use
MH  - Child, Preschool
MH  - Dental Care for Children/*economics
MH  - Dental Caries/economics/*prevention & control
MH  - Fluorides, Topical/economics/therapeutic use
MH  - Follow-Up Studies
MH  - Health Education, Dental/economics
MH  - Humans
MH  - Northern Ireland
MH  - Preventive Dentistry/economics
MH  - Primary Health Care/*economics
MH  - Toothbrushing/economics/instrumentation
MH  - Toothpastes/economics/therapeutic use
MH  - Treatment Outcome
PMC - PMC3196725
EDAT- 2011/10/12 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/10/12 06:00
PHST- 2011/07/22 00:00 [received]
PHST- 2011/10/10 00:00 [accepted]
PHST- 2011/10/12 06:00 [entrez]
PHST- 2011/10/12 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - 1472-6831-11-27 [pii]
AID - 10.1186/1472-6831-11-27 [doi]
PST - epublish
SO  - BMC Oral Health. 2011 Oct 10;11:27. doi: 10.1186/1472-6831-11-27.


PMID- 21985493
OWN - NLM
STAT- MEDLINE
DCOM- 20120223
LR  - 20220321
IS  - 1471-2458 (Electronic)
IS  - 1471-2458 (Linking)
VI  - 11
DP  - 2011 Oct 10
TI  - Determinants of fertility in rural Ethiopia: the case of Butajira Demographic
      Surveillance System (DSS).
PG  - 782
LID - 10.1186/1471-2458-11-782 [doi]
AB  - BACKGROUND: Fertility is high in rural Ethiopia. Women in the reproductive age
      group differed in various characteristics including access to food and encounter 
      to drought which requisite the assessment of determinants of fertility. METHODS: 
      Reproductive age women were recruited from a DSS, the Butajira DSS database. A
      DHS maternity history questionnaire was administered on 9996 participants. Data
      quality was assured besides ethical clearance. Poisson regression crude and
      adjusted Incidence Rate Ratio with 95 Confidence Interval were used to identify
      determinants of fertility. RESULTS: Delayed marriage, higher education, smaller
      family, absence of child death experience and living in food-secured households
      were associated with small number of children. Fertility was significantly higher
      among women with no child sex preference. However, migration status of women was 
      not statistically significant. CONCLUSIONS: Policy makers should focus on
      hoisting women secondary school enrollment and age at first marriage. The
      community should also be made aware on the negative impact of fertility on
      household economy, environmental degradation and the country's socio-economic
      development at large.
FAU - Mekonnen, Wubegzier
AU  - Mekonnen W
AD  - School of Public Health, College of Health Sciences, Addis Ababa University,
      Addis Ababa, Ethiopia. wubegzierm@gmail.com
FAU - Worku, Alemayehu
AU  - Worku A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111010
PL  - England
TA  - BMC Public Health
JT  - BMC public health
JID - 100968562
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Birth Rate/*trends
MH  - Educational Status
MH  - Ethiopia/epidemiology
MH  - Female
MH  - Fertility/*physiology
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Population Surveillance
MH  - Pregnancy
MH  - Rural Population/*statistics & numerical data
MH  - Sexual Behavior/statistics & numerical data
MH  - Socioeconomic Factors
MH  - Surveys and Questionnaires
MH  - Young Adult
PMC - PMC3201928
EDAT- 2011/10/12 06:00
MHDA- 2012/02/24 06:00
CRDT- 2011/10/12 06:00
PHST- 2011/07/08 00:00 [received]
PHST- 2011/10/10 00:00 [accepted]
PHST- 2011/10/12 06:00 [entrez]
PHST- 2011/10/12 06:00 [pubmed]
PHST- 2012/02/24 06:00 [medline]
AID - 1471-2458-11-782 [pii]
AID - 10.1186/1471-2458-11-782 [doi]
PST - epublish
SO  - BMC Public Health. 2011 Oct 10;11:782. doi: 10.1186/1471-2458-11-782.


PMID- 21985203
OWN - NLM
STAT- MEDLINE
DCOM- 20120224
LR  - 20151119
IS  - 1600-0579 (Electronic)
IS  - 1396-5883 (Linking)
VI  - 15
IP  - 4
DP  - 2011 Nov
TI  - Professional ethics and cynicism amongst Dutch dental students.
PG  - 205-9
LID - 10.1111/j.1600-0579.2010.00657.x [doi]
AB  - BACKGROUND: Some 40 years ago, Morris and Sherlock concluded that dental students
      are very cynical about their future profession, and indeed become more cynical as
      they progress through dental school. Later studies continued to report cynicism
      among dental students, but some studies did not confirm the reported increase.
      However, any degree of cynicism among matriculating students and even more so
      among graduating students should be of grave concern to dental educators. METHOD:
      This study used a survey modeled after the instrument used by Morris and
      Sherlock. First and fifth year students at one of the dental schools in The
      Netherlands were presented with 10 vignettes and asked to indicate how they
      themselves would respond, how practising dentists would respond and how any
      dentist should respond. RESULTS: We did not find a rise in cynicism. However, we 
      did find that both freshmen and graduating dental students in The Netherlands are
      rather cynical, as a group, about the ethics of their future profession. Even
      students who believe that the professional norms themselves are sound (as
      evidenced by their own willingness to abide by those norms) tend to believe that 
      many practising dentists regularly violate those norms. CONCLUSIONS: As was
      already reported some 40 years ago, dental students appear to harbour a
      widespread and persistent cynicism about the ethics of their future profession.
      The professionalism courses that are emerging in many dental schools around the
      world should take note of this challenging statistic.
CI  - 2011 John Wiley & Sons A/S.
FAU - Brands, W G
AU  - Brands WG
AD  - Department of Dentistry, Radboud University Nijmegen Medical Centre, Nijmegen,
      The Netherlands. w.brands@dent.umcn.nl
FAU - Bronkhorst, E M
AU  - Bronkhorst EM
FAU - Welie, J V M
AU  - Welie JV
LA  - eng
PT  - Journal Article
DEP - 20110317
PL  - England
TA  - Eur J Dent Educ
JT  - European journal of dental education : official journal of the Association for
      Dental Education in Europe
JID - 9712132
MH  - Attitude of Health Personnel
MH  - Dentist-Patient Relations/ethics
MH  - Education, Dental
MH  - Ethics, Dental/*education
MH  - Female
MH  - Humans
MH  - Male
MH  - *Negativism
MH  - Netherlands
MH  - Students, Dental/*psychology
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2011/10/12 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/10/12 06:00
PHST- 2011/10/12 06:00 [entrez]
PHST- 2011/10/12 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - 10.1111/j.1600-0579.2010.00657.x [doi]
PST - ppublish
SO  - Eur J Dent Educ. 2011 Nov;15(4):205-9. doi: 10.1111/j.1600-0579.2010.00657.x.
      Epub 2011 Mar 17.


PMID- 21984657
OWN - NLM
STAT- MEDLINE
DCOM- 20111222
LR  - 20220409
IS  - 1476-6256 (Electronic)
IS  - 0002-9262 (Linking)
VI  - 174
IP  - 10
DP  - 2011 Nov 15
TI  - Sojourn time of preclinical colorectal cancer by sex and age: estimates from the 
      German national screening colonoscopy database.
PG  - 1140-6
LID - 10.1093/aje/kwr188 [doi]
AB  - The sojourn time of preclinical colorectal cancer is a critical parameter in
      modeling effectiveness and cost-effectiveness of colorectal cancer screening. For
      ethical reasons, it cannot be observed directly, and available estimates are
      based mostly on relatively small historic data sets that do not include
      differentiation by age and sex. The authors derived sex- and age-specific
      estimates (age groups: 55-59, 60-64, 65-69, 70-74, 75-79, and >/=80 years) of
      mean sojourn time, combining data from the German national screening colonoscopy 
      registry (based on 1.88 million records) and data from population-based cancer
      registries (population base: 37.9 million people) for the years 2003-2006.
      Estimates of mean sojourn time were similar for both sexes and all age groups and
      ranged from 4.5 years (95% confidence interval: 4.1, 4.8) to 5.8 years (95%
      confidence interval: 5.3, 6.3) for the subgroups assessed. Sensitivity analyses
      indicated that mean sojourn time might be approximately 1.5 years longer if
      colorectal cancer prevalence in nonparticipants of screening colonoscopy is 20%
      lower than prevalence in participants or 1 year shorter if it exceeds the
      prevalence in participants by 20%. This study provides, for the first time,
      precise estimates of sojourn time by age and sex, and it suggests that sojourn
      times are remarkably consistent across age groups and in both sexes.
FAU - Brenner, Hermann
AU  - Brenner H
AD  - Division of Clinical Epidemiology and Aging Research, German Cancer
      ResearchCenter, Im Neuenheimer Feld 581, Heidelberg, Germany. h.brenner@dkfz.de
FAU - Altenhofen, Lutz
AU  - Altenhofen L
FAU - Katalinic, Alexander
AU  - Katalinic A
FAU - Lansdorp-Vogelaar, Iris
AU  - Lansdorp-Vogelaar I
FAU - Hoffmeister, Michael
AU  - Hoffmeister M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111007
PL  - United States
TA  - Am J Epidemiol
JT  - American journal of epidemiology
JID - 7910653
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Colonoscopy/*statistics & numerical data
MH  - Colorectal Neoplasms/*diagnosis/*epidemiology
MH  - Early Detection of Cancer/*statistics & numerical data
MH  - Germany/epidemiology
MH  - Humans
MH  - Middle Aged
MH  - Prevalence
MH  - Sensitivity and Specificity
MH  - Sex Factors
MH  - Time Factors
EDAT- 2011/10/11 06:00
MHDA- 2011/12/23 06:00
CRDT- 2011/10/11 06:00
PHST- 2011/10/11 06:00 [entrez]
PHST- 2011/10/11 06:00 [pubmed]
PHST- 2011/12/23 06:00 [medline]
AID - kwr188 [pii]
AID - 10.1093/aje/kwr188 [doi]
PST - ppublish
SO  - Am J Epidemiol. 2011 Nov 15;174(10):1140-6. doi: 10.1093/aje/kwr188. Epub 2011
      Oct 7.


PMID- 21984333
OWN - NLM
STAT- MEDLINE
DCOM- 20120727
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 17
IP  - 4
DP  - 2011 Dec
TI  - Negotiating plausibility: intervening in the future of nanotechnology.
PG  - 723-37
LID - 10.1007/s11948-011-9315-x [doi]
AB  - The national-level scenarios project NanoFutures focuses on the social,
      political, economic, and ethical implications of nanotechnology, and is initiated
      by the Center for Nanotechnology in Society at Arizona State University
      (CNS-ASU). The project involves novel methods for the development of plausible
      visions of nanotechnology-enabled futures, elucidates public preferences for
      various alternatives, and, using such preferences, helps refine future visions
      for research and outreach. In doing so, the NanoFutures project aims to address a
      central question: how to deliberate the social implications of an emergent
      technology whose outcomes are not known. The solution pursued by the NanoFutures 
      project is twofold. First, NanoFutures limits speculation about the technology to
      plausible visions. This ambition introduces a host of concerns about the limits
      of prediction, the nature of plausibility, and how to establish plausibility.
      Second, it subjects these visions to democratic assessment by a range of
      stakeholders, thus raising methodological questions as to who are relevant
      stakeholders and how to activate different communities so as to engage the far
      future. This article makes the dilemmas posed by decisions about such
      methodological issues transparent and therefore articulates the role of
      plausibility in anticipatory governance.
FAU - Selin, Cynthia
AU  - Selin C
AD  - Arizona State University, Tempe, AZ, USA. cynthia.selin@asu.edu
LA  - eng
PT  - Journal Article
DEP - 20111008
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
CIN - Sci Eng Ethics. 2011 Dec;17(4):739-42. PMID: 21877249
MH  - Arizona
MH  - *Community Participation
MH  - *Consumer Behavior
MH  - *Democracy
MH  - Goals
MH  - Humans
MH  - *Nanotechnology
MH  - *Research
MH  - Residence Characteristics
MH  - *Social Values
MH  - Universities
EDAT- 2011/10/11 06:00
MHDA- 2012/07/28 06:00
CRDT- 2011/10/11 06:00
PHST- 2007/12/03 00:00 [received]
PHST- 2011/09/16 00:00 [accepted]
PHST- 2011/10/11 06:00 [entrez]
PHST- 2011/10/11 06:00 [pubmed]
PHST- 2012/07/28 06:00 [medline]
AID - 10.1007/s11948-011-9315-x [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2011 Dec;17(4):723-37. doi: 10.1007/s11948-011-9315-x. Epub 2011 
      Oct 8.


PMID- 21983911
OWN - NLM
STAT- MEDLINE
DCOM- 20111206
LR  - 20191112
IS  - 0383-6320 (Print)
IS  - 0383-6320 (Linking)
VI  - 36
IP  - 1
DP  - 2011 Spring
TI  - [Methods of psychotherapy case studies: current perspectives].
PG  - 201-16
AB  - There is a renewal of interest among psychotherapy researchers and
      psychotherapists towards psychotherapy case studies. This article presents two
      paradigms that have greatly influenced this increasing interest in psychotherapy 
      case studies : the pragmatic case study and the theory-building case study
      paradigm. The origins, developments and key-concepts of both paradigms are
      presented, as well as their methodological and ethical specificities. Examples of
      case studies, along with models developed, are cited. The differential influence 
      of the post-modern schools on both paradigms are presented, as well as their
      contribution to the field of methods of psychotherapy case studies discussed and 
      assessed in terms of relevance for the researcher and the psychotherapist.
FAU - Kramer, Ueli
AU  - Kramer U
AD  - Institut Universitaire de Psychotherapie et Section Karl Jaspers-DP-CHUV,
      Cedres-Site de Cery, Lausanne, Suisse.
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Les methodes d'etudes de cas en psychotherapie: perspectives actuelles.
PL  - Canada
TA  - Sante Ment Que
JT  - Sante mentale au Quebec
JID - 9424773
SB  - IM
MH  - Evidence-Based Practice
MH  - Humans
MH  - Psychotherapy/*methods
EDAT- 2011/10/11 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/10/11 06:00
PHST- 2011/10/11 06:00 [entrez]
PHST- 2011/10/11 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 1005821ar [pii]
AID - 10.7202/1005821ar [doi]
PST - ppublish
SO  - Sante Ment Que. 2011 Spring;36(1):201-16. doi: 10.7202/1005821ar.


PMID- 21983623
OWN - NLM
STAT- MEDLINE
DCOM- 20120529
LR  - 20211020
IS  - 1559-2030 (Electronic)
IS  - 1551-7144 (Linking)
VI  - 33
IP  - 1
DP  - 2012 Jan
TI  - Nurse Practitioners' attitudes about cancer clinical trials and willingness to
      recommend research participation.
PG  - 76-84
LID - 10.1016/j.cct.2011.09.005 [doi]
AB  - BACKGROUND: Recruitment and retention of human participants in cancer clinical
      trials remains challenging for all investigators. Nurse Practitioners (NPs) are
      in a prime position to discuss, educate and refer patients to clinical trials as 
      many NPs work in ethnically and geographically diverse primary care settings in
      the U.S., yet they remain an untapped resource. We examined NPs' general
      attitudes toward cancer clinical trial recommendations and assessed their
      willingness to recommend such trials METHODS: We randomly surveyed 455 primary
      care NPs in the state of Pennsylvania during 2008 with an adjusted response rate 
      of 55.3%. Descriptive statistics were used to characterize NPs' demographic and
      practice characteristics, and logistic regression was used to assess the relative
      influence of the various attitudes and beliefs on the likelihood that the NP
      would bring up clinical trials as a treatment option. RESULTS: NPs were more
      likely to bring up the topic of clinical trials with at least some patients if
      they were comfortable discussing treatment options with their cancer patients
      (OR=4.29, p=0.001), were comfortable discussing options of entering a clinical
      trial for treatment (OR=3.54, p=0.003), had adequate time during patients' visit 
      to explain clinical trials (OR=3.40, p=0.008), and if they believed that patients
      in clinical trials were receiving the best medical treatment (OR=3.34, p=0.019). 
      NPs who were comfortable discussing cancer clinical trials were almost 5 times
      more likely to think clinical trials were useful (OR=4.70; 95% CI=1.81-12.19;
      p=0.001). Nearly three-quarters (72.6%) of the entire responder sample reported
      three or more ethical concerns associated with clinical trials, including issues 
      of randomization, informed consent, and patient burden. CONCLUSIONS: NPs are
      willing to recommend clinical trials but need more education about the benefits
      and burdens of clinical trials, the associated ethical concerns, and evidence
      regarding the translatability of research to clinical practice to increase their 
      knowledge and comfort level with discussing clinical trials.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Ulrich, Connie M
AU  - Ulrich CM
AD  - School of Nursing, and Center for Bioethics and NewCourtlandCenter for
      Transitions and Health, University of Pennsylvania, Philadelphia, Pennsylvania
      19106, United States. culrich@nursing.upenn.edu
FAU - Zhou, Quiping
AU  - Zhou Q
FAU - Ratcliffe, Sarah J
AU  - Ratcliffe SJ
FAU - Ye, Lichuan
AU  - Ye L
FAU - Grady, Christine
AU  - Grady C
FAU - Watkins-Bruner, Deborah
AU  - Watkins-Bruner D
LA  - eng
GR  - Z99 CL999999/ImNIH/Intramural NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110929
PL  - United States
TA  - Contemp Clin Trials
JT  - Contemporary clinical trials
JID - 101242342
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Attitude of Health Personnel
MH  - Clinical Competence/*standards
MH  - *Clinical Trials as Topic
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/*therapy
MH  - Nurse Practitioners/*psychology
MH  - Nurse's Role/*psychology
MH  - Nursing Evaluation Research/*methods
MH  - Pennsylvania
MH  - Surveys and Questionnaires
PMC - PMC4819416
MID - NIHMS771801
EDAT- 2011/10/11 06:00
MHDA- 2012/05/30 06:00
CRDT- 2011/10/11 06:00
PHST- 2011/05/30 00:00 [received]
PHST- 2011/09/15 00:00 [revised]
PHST- 2011/09/20 00:00 [accepted]
PHST- 2011/10/11 06:00 [entrez]
PHST- 2011/10/11 06:00 [pubmed]
PHST- 2012/05/30 06:00 [medline]
AID - S1551-7144(11)00238-2 [pii]
AID - 10.1016/j.cct.2011.09.005 [doi]
PST - ppublish
SO  - Contemp Clin Trials. 2012 Jan;33(1):76-84. doi: 10.1016/j.cct.2011.09.005. Epub
      2011 Sep 29.


PMID- 21983595
OWN - NLM
STAT- Publisher
LR  - 20191120
IS  - 1530-0366 (Electronic)
IS  - 1098-3600 (Linking)
DP  - 2011 Oct 7
TI  - Revisiting the Wilson-Jungner criteria: How can supplemental criteria guide
      public health in the era of genetic screening?
AB  - PURPOSE:: Advances in technology have made newborn screening for more than 50
      inborn errors of metabolism possible using a dried blood sample. A framework is
      proposed that public health practitioners may use when considering candidate
      disorders for newborn screening panels. METHODS:: The framework expands on the 10
      Wilson-Jungner criteria with the addition of 11 criteria specific to newborn
      screening. A calculation, the "pNBS Decision Score," is used to quantify results 
      and rank candidate disorders. RESULTS:: The pNBS Decision Scores that were
      calculated for phenylketonuria (OMIM# 261600), cystic fibrosis (OMIM# 219700),
      Pompe disease (OMIM# 232300), and severe combined immunodeficiency (OMIM# 102700)
      support their inclusion as newborn screening disorders. The pNBS Decision Score
      suggests that Krabbe disease (OMIM# 245200) is not a candidate disorder for
      inclusion at this time. CONCLUSION:: The proposed framework adds to the ability
      of policy makers to quantify an essential portion of the process for adding
      disorders to newborn screening panels. Other factors such as ethical, legal, and 
      social issues, clinical utility, and advocacy are also part of the policy
      process. The framework is not intended to replace existing nomination processes
      but rather to enhance those processes by encouraging iterative review of newborn 
      screening-specific criteria. The use of the framework will provide consistency
      across a portion of the decision process. The public health community should take
      the opportunity to revisit the screening determinants of the Wilson-Jungner
      criteria from a 21st century perspective. The results suggest that this framework
      provides the public health practitioner with a consistent process for making an
      evidence-based decision.
FAU - Petros, Michael
AU  - Petros M
AD  - From the University of Illinois, School of Public Health, Chicago, Illinois.
LA  - eng
PT  - Journal Article
DEP - 20111007
PL  - United States
TA  - Genet Med
JT  - Genetics in medicine : official journal of the American College of Medical
      Genetics
JID - 9815831
EDAT- 2011/10/11 06:00
MHDA- 2011/10/11 06:00
CRDT- 2011/10/11 06:00
PHST- 2011/10/11 06:00 [entrez]
PHST- 2011/10/11 06:00 [pubmed]
PHST- 2011/10/11 06:00 [medline]
AID - 10.1097/GIM.0b013e31823331d0 [doi]
PST - aheadofprint
SO  - Genet Med. 2011 Oct 7. doi: 10.1097/GIM.0b013e31823331d0.


PMID- 21983000
OWN - NLM
STAT- MEDLINE
DCOM- 20120223
LR  - 20220330
IS  - 1879-1883 (Electronic)
IS  - 0002-9610 (Linking)
VI  - 203
IP  - 1
DP  - 2012 Jan
TI  - The professionalism curriculum as a cultural change agent in surgical residency
      education.
PG  - 14-20
LID - 10.1016/j.amjsurg.2011.05.007 [doi]
AB  - BACKGROUND: Teaching professionalism effectively to fully engaged residents is a 
      significant challenge. A key question is whether the integration of
      professionalism into residency education leads to a change in resident culture.
      METHODS: The goal of this study was to assess whether professionalism has taken
      root in the surgical resident culture 3 years after implementing our
      professionalism curriculum. Evidence was derived from 3 studies: (1) annual
      self-assessments of the residents' perceived professionalism abilities to perform
      20 defined tasks representing core Accrediting Council on Graduate Medical
      Education professionalism domains, (2) objective metrics of their demonstrated
      professionalism skills as rated by standardized patients annually using the
      objective structure clinical examination tool, and (3) a national survey of the
      Surgical Professionalism and Interpersonal Communications Education Study Group. 
      RESULTS: Study 1: aggregate perceived professionalism among surgical residents
      shows a statistically significant positive trend over time (P = .016).
      Improvements were seen in all 6 domains: accountability, ethics, altruism,
      excellence, patient sensitivity, and respect. Study 2: the cohort of residents
      followed up over 3 years showed a marked improvement in their professionalism
      skills as rated by standardized patients using the objective structure clinical
      examination tool. Study 3: 41 members of the national Surgical Professionalism
      and Interpersonal Communications Education Study Group rated their residents'
      skills in admitting mistakes, delivering bad news, communication,
      interdisciplinary respect, cultural competence, and handling stress. Twenty-nine 
      of the 41 responses rated their residents as "slightly better" or "much better"
      compared with 5 years ago (P = .001). Thirty-four of the 41 programs
      characterized their department's leadership view toward professionalism as "much 
      better" compared with 5 years ago. CONCLUSIONS: All 3 assessment methods suggest 
      that residents feel increasingly prepared to effectively deal with the
      professionalism challenges they face. Although professionalism seminars may have 
      seemed like an oddity several years ago, residents today recognize their
      importance and value their professionalism skills. As importantly, department
      chairpersons report that formal professionalism education for residents is viewed
      more favorably compared with 5 years ago.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Hochberg, Mark S
AU  - Hochberg MS
AD  - Department of Surgery, New York University Medical Center, 550 First Ave., NBV 15
      N1, New York, NY 10016, USA. mark.hochberg@nyumc.org
FAU - Berman, Russell S
AU  - Berman RS
FAU - Kalet, Adina L
AU  - Kalet AL
FAU - Zabar, Sondra R
AU  - Zabar SR
FAU - Gillespie, Colleen
AU  - Gillespie C
FAU - Pachter, H Leon
AU  - Pachter HL
CN  - Surgical Professionalism and Interpersonal Communications Education Study Group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111008
PL  - United States
TA  - Am J Surg
JT  - American journal of surgery
JID - 0370473
SB  - IM
MH  - Adult
MH  - Altruism
MH  - Attitude of Health Personnel
MH  - Communication
MH  - Conflict of Interest
MH  - *Curriculum
MH  - Education, Medical, Graduate/*methods
MH  - Ethics, Medical
MH  - Female
MH  - General Surgery/*education
MH  - Humans
MH  - *Internship and Residency
MH  - Interprofessional Relations
MH  - Male
MH  - New York City
MH  - Patient Simulation
MH  - Physician-Patient Relations
MH  - Privacy
MH  - *Professional Competence
MH  - Self-Assessment
MH  - Surveys and Questionnaires
MH  - Truth Disclosure
EDAT- 2011/10/11 06:00
MHDA- 2012/02/24 06:00
CRDT- 2011/10/11 06:00
PHST- 2011/03/30 00:00 [received]
PHST- 2011/05/23 00:00 [revised]
PHST- 2011/05/23 00:00 [accepted]
PHST- 2011/10/11 06:00 [entrez]
PHST- 2011/10/11 06:00 [pubmed]
PHST- 2012/02/24 06:00 [medline]
AID - S0002-9610(11)00426-0 [pii]
AID - 10.1016/j.amjsurg.2011.05.007 [doi]
PST - ppublish
SO  - Am J Surg. 2012 Jan;203(1):14-20. doi: 10.1016/j.amjsurg.2011.05.007. Epub 2011
      Oct 8.


PMID- 21982589
OWN - NLM
STAT- MEDLINE
DCOM- 20120111
LR  - 20211020
IS  - 1755-8794 (Electronic)
IS  - 1755-8794 (Linking)
VI  - 4
DP  - 2011 Oct 7
TI  - "Who owns your poop?": insights regarding the intersection of human microbiome
      research and the ELSI aspects of biobanking and related studies.
PG  - 72
LID - 10.1186/1755-8794-4-72 [doi]
AB  - BACKGROUND: While the social, ethical, and legal implications of biobanking and
      large scale data sharing are already complicated enough, they may be further
      compounded by research on the human microbiome. DISCUSSION: The human microbiome 
      is the entire complement of microorganisms that exists in and on every human
      body. Currently most biobanks focus primarily on human tissues and/or associated 
      data (e.g. health records). Accordingly, most discussions in the social sciences 
      and humanities on these issues are focused (appropriately so) on the implications
      of biobanks and sharing data derived from human tissues. However, rapid advances 
      in human microbiome research involve collecting large amounts of data on
      microorganisms that exist in symbiotic relationships with the human body.
      Currently it is not clear whether these microorganisms should be considered part 
      of or separate from the human body. Arguments can be made for both, but
      ultimately it seems that the dichotomy of human versus non-human and self versus 
      non-self inevitably breaks down in this context. This situation has the potential
      to add further complications to debates on biobanking. SUMMARY: In this paper, we
      revisit some of the core problem areas of privacy, consent, ownership, return of 
      results, governance, and benefit sharing, and consider how they might be impacted
      upon by human microbiome research. Some of the issues discussed also have
      relevance to other forms of microbial research. Discussion of these themes is
      guided by conceptual analysis of microbiome research and interviews with leading 
      Canadian scientists in the field.
FAU - Hawkins, Alice K
AU  - Hawkins AK
AD  - Department of Psychology, University of Guelph, Guelph, ON, N1G 2W1, Canada.
FAU - O'Doherty, Kieran C
AU  - O'Doherty KC
LA  - eng
GR  - 94314/CAPMC/ CIHR/Canada
GR  - 193095/CAPMC/ CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111007
PL  - England
TA  - BMC Med Genomics
JT  - BMC medical genomics
JID - 101319628
SB  - IM
MH  - *Biological Specimen Banks/economics/ethics/legislation & jurisprudence
MH  - Consent Forms/economics/ethics/legislation & jurisprudence
MH  - Ethics, Research
MH  - Humans
MH  - Interviews as Topic
MH  - *Metagenome
MH  - Ownership/economics/ethics/legislation & jurisprudence
MH  - Privacy/legislation & jurisprudence
MH  - Research/economics/legislation & jurisprudence
PMC - PMC3199231
EDAT- 2011/10/11 06:00
MHDA- 2012/01/12 06:00
CRDT- 2011/10/11 06:00
PHST- 2011/02/18 00:00 [received]
PHST- 2011/10/07 00:00 [accepted]
PHST- 2011/10/11 06:00 [entrez]
PHST- 2011/10/11 06:00 [pubmed]
PHST- 2012/01/12 06:00 [medline]
AID - 1755-8794-4-72 [pii]
AID - 10.1186/1755-8794-4-72 [doi]
PST - epublish
SO  - BMC Med Genomics. 2011 Oct 7;4:72. doi: 10.1186/1755-8794-4-72.


PMID- 21982393
OWN - NLM
STAT- MEDLINE
DCOM- 20130830
LR  - 20141120
IS  - 1879-1700 (Electronic)
IS  - 0265-931X (Linking)
VI  - 119
DP  - 2013 May
TI  - Social and ethical issues in environmental remediation projects.
PG  - 21-5
LID - 10.1016/j.jenvrad.2011.08.019 [doi]
LID - S0265-931X(11)00210-4 [pii]
AB  - The contamination of environments with radionuclides can give rise to
      consequences that encompass far more than health risks from exposure to
      radiation. As experience from Chernobyl demonstrated, both the accident and
      remediation measures can have serious social and economic consequences. This
      paper presents a review of some of these issues, including their ethical
      relevance, and presents a check-list of socio-ethical aspects of remediation
      measures. The paper concludes with an overview of social remediation measures,
      encompassing actions that are directed towards benefits other than dose reduction
      (e.g., local food monitoring stations or medical check-up), or measures that
      require social rather than technical implementation (e.g. information centres,
      stakeholder dialogue).
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Oughton, D H
AU  - Oughton DH
AD  - Department of Plant and Environmental Sciences, Norwegian University of Life
      Sciences, Box 5003, 1432 Aas, Norway. deborah.oughton@umb.no
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111007
PL  - England
TA  - J Environ Radioact
JT  - Journal of environmental radioactivity
JID - 8508119
RN  - 0 (Radioactive Pollutants)
SB  - IM
MH  - *Chernobyl Nuclear Accident
MH  - Compensation and Redress
MH  - Environmental Restoration and Remediation/economics/*ethics
MH  - Radiation Monitoring
MH  - *Radioactive Pollutants
MH  - Social Responsibility
EDAT- 2011/10/11 06:00
MHDA- 2013/08/31 06:00
CRDT- 2011/10/11 06:00
PHST- 2010/04/11 00:00 [received]
PHST- 2011/08/23 00:00 [revised]
PHST- 2011/08/31 00:00 [accepted]
PHST- 2011/10/11 06:00 [entrez]
PHST- 2011/10/11 06:00 [pubmed]
PHST- 2013/08/31 06:00 [medline]
AID - S0265-931X(11)00210-4 [pii]
AID - 10.1016/j.jenvrad.2011.08.019 [doi]
PST - ppublish
SO  - J Environ Radioact. 2013 May;119:21-5. doi: 10.1016/j.jenvrad.2011.08.019. Epub
      2011 Oct 7.


PMID- 21982229
OWN - NLM
STAT- MEDLINE
DCOM- 20120416
LR  - 20160518
IS  - 1875-9777 (Electronic)
IS  - 1875-9777 (Linking)
VI  - 9
IP  - 4
DP  - 2011 Oct 4
TI  - Moving human SCNT research forward ethically.
PG  - 295-7
LID - 10.1016/j.stem.2011.08.001 [doi]
AB  - A recent study of human somatic cells reprogrammed to a pluripotent state via
      somatic cell nuclear transfer (SCNT) will undoubtedly renew interest in human egg
      procurement. Thus it is imperative that human SCNT research move forward under
      stringent ethical standards in locales permitting directed egg donation for stem 
      cell research.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Hyun, Insoo
AU  - Hyun I
AD  - Department of Bioethics, Case Western Reserve University School of Medicine,
      Cleveland, OH 44106-4976, USA. insoo.hyun@case.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Cell Stem Cell
JT  - Cell stem cell
JID - 101311472
SB  - IM
MH  - Guidelines as Topic
MH  - Humans
MH  - Nuclear Transfer Techniques/economics/*ethics
MH  - Oocyte Donation/economics
MH  - Stem Cell Research/economics/*ethics
EDAT- 2011/10/11 06:00
MHDA- 2012/04/17 06:00
CRDT- 2011/10/11 06:00
PHST- 2011/10/11 06:00 [entrez]
PHST- 2011/10/11 06:00 [pubmed]
PHST- 2012/04/17 06:00 [medline]
AID - S1934-5909(11)00382-1 [pii]
AID - 10.1016/j.stem.2011.08.001 [doi]
PST - ppublish
SO  - Cell Stem Cell. 2011 Oct 4;9(4):295-7. doi: 10.1016/j.stem.2011.08.001.


PMID- 21982119
OWN - NLM
STAT- MEDLINE
DCOM- 20120217
LR  - 20220408
IS  - 1471-227X (Electronic)
IS  - 1471-227X (Linking)
VI  - 11
DP  - 2011 Oct 7
TI  - Emergency department triage: an ethical analysis.
PG  - 16
LID - 10.1186/1471-227X-11-16 [doi]
AB  - BACKGROUND: Emergency departments across the globe follow a triage system in
      order to cope with overcrowding. The intention behind triage is to improve the
      emergency care and to prioritize cases in terms of clinical urgency. DISCUSSION: 
      In emergency department triage, medical care might lead to adverse consequences
      like delay in providing care, compromise in privacy and confidentiality, poor
      physician-patient communication, failing to provide the necessary care
      altogether, or even having to decide whose life to save when not everyone can be 
      saved. These consequences challenge the ethical quality of emergency care. This
      article provides an ethical analysis of "routine" emergency department triage.
      The four principles of biomedical ethics - viz. respect for autonomy,
      beneficence, nonmaleficence and justice provide the starting point and help us to
      identify the ethical challenges of emergency department triage. However, they do 
      not offer a comprehensive ethical view. To address the ethical issues of
      emergency department triage from a more comprehensive ethical view, the care
      ethics perspective offers additional insights. SUMMARY: We integrate the results 
      from the analysis using four principles of biomedical ethics into care ethics
      perspective on triage and propose an integrated clinically and ethically based
      framework of emergency department triage planning, as seen from a comprehensive
      ethics perspective that incorporates both the principles-based and care-oriented 
      approach.
FAU - Aacharya, Ramesh P
AU  - Aacharya RP
AD  - Department of General Practice & Emergency Medicine, Tribhuvan University
      Teaching Hospital, Maharajgunj, Kathmandu, Nepal. raacharya@healthnet.org.np
FAU - Gastmans, Chris
AU  - Gastmans C
FAU - Denier, Yvonne
AU  - Denier Y
LA  - eng
PT  - Journal Article
DEP - 20111007
PL  - England
TA  - BMC Emerg Med
JT  - BMC emergency medicine
JID - 100968543
SB  - IM
MH  - Beneficence
MH  - Confidentiality
MH  - Emergency Service, Hospital/*ethics
MH  - *Ethical Analysis
MH  - Humans
MH  - Patient Care/ethics
MH  - Personal Autonomy
MH  - Physician-Patient Relations
MH  - Practice Guidelines as Topic
MH  - Social Justice
MH  - Triage/*ethics
PMC - PMC3199257
EDAT- 2011/10/11 06:00
MHDA- 2012/02/18 06:00
CRDT- 2011/10/11 06:00
PHST- 2010/11/23 00:00 [received]
PHST- 2011/10/07 00:00 [accepted]
PHST- 2011/10/11 06:00 [entrez]
PHST- 2011/10/11 06:00 [pubmed]
PHST- 2012/02/18 06:00 [medline]
AID - 1471-227X-11-16 [pii]
AID - 10.1186/1471-227X-11-16 [doi]
PST - epublish
SO  - BMC Emerg Med. 2011 Oct 7;11:16. doi: 10.1186/1471-227X-11-16.


PMID- 21981747
OWN - NLM
STAT- MEDLINE
DCOM- 20120305
LR  - 20181201
IS  - 1432-2277 (Electronic)
IS  - 0934-0874 (Linking)
VI  - 24
IP  - 12
DP  - 2011 Dec
TI  - Making an offer you can't refuse? A challenge of altruistic donation.
PG  - 1159-61
LID - 10.1111/j.1432-2277.2011.01367.x [doi]
AB  - Living donation is becoming increasingly used to help fill the gap between the
      needs of potential organ recipients and the availability of organs from deceased 
      donors. The last few years has seen a small, but increasing contribution from
      altruistic (or good Samaritan or nondirected) donors. However, use of organs from
      such donors is associated with ethical as well as practical issues. The rights of
      the well-informed and consented donor to donate must be balanced against the
      rights of the surgeons to decline to offer such a service.
CI  - (c) 2011 The Author. Transplant International (c) 2011 European Society for Organ
      Transplantation.
FAU - Neuberger, James
AU  - Neuberger J
AD  - Organ Donation and Transplantation, NHS Blood and Transplant, Bristol, UK.
      james.neuberger@nhsbt.nhs.uk
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20111008
PL  - Switzerland
TA  - Transpl Int
JT  - Transplant international : official journal of the European Society for Organ
      Transplantation
JID - 8908516
SB  - IM
CON - Transpl Int. 2011 Dec;24(12):1164-9. PMID: 21910764
MH  - *Altruism
MH  - Humans
MH  - Living Donors/*ethics
MH  - Tissue and Organ Procurement/*ethics
EDAT- 2011/10/11 06:00
MHDA- 2012/03/06 06:00
CRDT- 2011/10/11 06:00
PHST- 2011/10/11 06:00 [entrez]
PHST- 2011/10/11 06:00 [pubmed]
PHST- 2012/03/06 06:00 [medline]
AID - 10.1111/j.1432-2277.2011.01367.x [doi]
PST - ppublish
SO  - Transpl Int. 2011 Dec;24(12):1159-61. doi: 10.1111/j.1432-2277.2011.01367.x. Epub
      2011 Oct 8.


PMID- 21981134
OWN - NLM
STAT- MEDLINE
DCOM- 20120228
LR  - 20161125
IS  - 1349-7006 (Electronic)
IS  - 1347-9032 (Linking)
VI  - 103
IP  - 1
DP  - 2012 Jan
TI  - Multidetector row helical computed tomography for invasive ductal carcinoma of
      the breast: correlation between radiological findings and the corresponding
      biological characteristics of patients.
PG  - 67-72
LID - 10.1111/j.1349-7006.2011.02116.x [doi]
AB  - The aim of this study is to evaluate the correlation between multidetector row
      helical computed tomography (MDCT) findings and the histopathological
      characteristics of patients with invasive ductal carcinoma. We retrospectively
      reviewed MDCT findings and the corresponding histopathological features of 442
      women with invasive ductal carcinoma. We received informed consent from the
      patients and the protocol was approved by the Ethics Committee at Tohoku
      University. The median age was 53 years (26-89 years). We examined the MDCT
      findings based on mass shape classified into well, moderate, poorly and scattered
      demarcated shapes, the enhancement pattern classified into homogenous,
      heterogeneous, rim and poor, and mass density classified into high, intermediate 
      or low. We subsequently compared these radiological findings with the
      histological characteristics and clinical outcome. Poorly demarcated types were
      higher in ER+/HER2- (P = 0.008), while the well-demarcated type was higher in
      ER-/HER2- and ER-/HER2+ (P < 0.001 and P = 0.010). Rim pattern was higher in
      ER-/HER2- (P < 0.001). Intermediate or low density was higher in ER-/HER2- (P <
      0.001, respectively). Further analysis based on histological grade, mitotic
      counts and lymphovascular invasion demonstrated that the well-demarcated shape
      was higher in grade 2 and 3 (P = 0.006 and P < 0.001, respectively), and rim
      pattern was observed in grade 3 (P < 0.001). Regarding mitotic counts, poorly and
      scattered demarcated shapes were observed in score 1 (P = 0.008 and P = 0.014),
      while well-demarcated shape and rim enhancement were observed in score 3 (P <
      0.001, respectively). Lymphovascular invasion correlated with a moderate
      demarcated shape (P = 0.029). Regarding recurrence rates, there were
      statistically significant differences between well and moderate, poorly or
      scattered demarcated shapes (P = 0.007, 0.028 and 0.035, respectively). These
      proposed MDCT diagnostic criteria based on biological characteristics contribute 
      to more accurately predicting the biological behavior of breast cancer patients.
CI  - (c) 2011 Japanese Cancer Association.
FAU - Tamaki, Kentaro
AU  - Tamaki K
AD  - Department of Surgical Oncology, Tohoku University Graduate School of Medicine,
      Miyagi, Japan. nahanisikenta@yahoo.co.jp
FAU - Ishida, Takanori
AU  - Ishida T
FAU - Miyashita, Minoru
AU  - Miyashita M
FAU - Amari, Masakazu
AU  - Amari M
FAU - Mori, Naoko
AU  - Mori N
FAU - Ohuchi, Noriaki
AU  - Ohuchi N
FAU - Tamaki, Nobumitsu
AU  - Tamaki N
FAU - Sasano, Hironobu
AU  - Sasano H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111103
PL  - England
TA  - Cancer Sci
JT  - Cancer science
JID - 101168776
RN  - 0 (Receptors, Estrogen)
RN  - EC 2.7.10.1 (Receptor, ErbB-2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Breast Neoplasms/*diagnostic imaging/mortality/*pathology
MH  - Carcinoma, Ductal, Breast/*diagnostic imaging/mortality/*pathology
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - *Multidetector Computed Tomography
MH  - Prognosis
MH  - Receptor, ErbB-2/metabolism
MH  - Receptors, Estrogen/metabolism
MH  - Retrospective Studies
MH  - Survival Rate
EDAT- 2011/10/11 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/10/11 06:00
PHST- 2011/10/11 06:00 [entrez]
PHST- 2011/10/11 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - 10.1111/j.1349-7006.2011.02116.x [doi]
PST - ppublish
SO  - Cancer Sci. 2012 Jan;103(1):67-72. doi: 10.1111/j.1349-7006.2011.02116.x. Epub
      2011 Nov 3.


PMID- 21980895
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20191112
IS  - 0093-0334 (Print)
IS  - 0093-0334 (Linking)
VI  - 41
IP  - 5
DP  - 2011 Sep-Oct
TI  - Questioning the universality of medical ethics: dilemmas raised performing
      surgery around the globe.
PG  - 18-22
FAU - Rose, Aron D
AU  - Rose AD
AD  - Yale School of Medicine, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Hastings Cent Rep
JT  - The Hastings Center report
JID - 0410447
SB  - IM
CIN - Hastings Cent Rep. 2012 May-Jun;42(3):8-9. PMID: 22670291
MH  - *Cross-Cultural Comparison
MH  - Decision Making/ethics
MH  - Developed Countries
MH  - Developing Countries
MH  - *Ethics, Medical
MH  - General Surgery/*ethics/methods
MH  - Health Status Disparities
MH  - Healthcare Disparities
MH  - Humans
MH  - International Cooperation
MH  - Medically Underserved Area
MH  - Ophthalmologic Surgical Procedures/ethics/methods
MH  - Patient Selection/*ethics
MH  - Risk Assessment
MH  - Standard of Care/ethics
MH  - Triage/*ethics/methods
MH  - Volunteers
EDAT- 2011/10/11 06:00
MHDA- 2011/11/09 06:00
CRDT- 2011/10/11 06:00
PHST- 2011/10/11 06:00 [entrez]
PHST- 2011/10/11 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - 10.1002/j.1552-146x.2011.tb00136.x [doi]
PST - ppublish
SO  - Hastings Cent Rep. 2011 Sep-Oct;41(5):18-22. doi:
      10.1002/j.1552-146x.2011.tb00136.x.


PMID- 21980257
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1718-7729 (Electronic)
IS  - 1198-0052 (Linking)
VI  - 18
IP  - 5
DP  - 2011 Oct
TI  - Canadian College of Medical Geneticists guidelines for the indications, analysis,
      and reporting of cancer specimens.
PG  - e250-5
AB  - The Canadian College of Medical Geneticists (ccmg) is a national organization of 
      medical and laboratory geneticists. The mission of the ccmg is to establish and
      maintain high-quality professional and ethical standards for medical genetics
      services in Canada and to help to ensure that service of the highest quality is
      delivered to the Canadian public.Cancer cytogenetics is one of the sections of
      practice of the ccmg. The ccmg Cytogenetic Committee has, therefore, put forward 
      guidelines to provide oncologists and ccmg cytogeneticists with a comprehensive
      review of the cytogenetic diagnostic tests that are recommended as a minimum
      standard of care for tumours of hematopoietic and lymphoid tissues and for
      tumours of soft tissue and bone. The guidelines were approved by the ccmg board
      of directors in June 2010.
FAU - Dawson, A J
AU  - Dawson AJ
AD  - Cytogenetics Laboratory, Diagnostic Services Manitoba, Winnipeg, MB. (Chair, ccmg
      Cytogenetic Committee 2009-2010).
FAU - McGowan-Jordan, J
AU  - McGowan-Jordan J
FAU - Chernos, J
AU  - Chernos J
FAU - Xu, J
AU  - Xu J
FAU - Lavoie, J
AU  - Lavoie J
FAU - Wang, J C
AU  - Wang JC
FAU - Steinraths, M
AU  - Steinraths M
FAU - Shetty, S
AU  - Shetty S
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Curr Oncol
JT  - Current oncology (Toronto, Ont.)
JID - 9502503
PMC - PMC3185907
OTO - NOTNLM
OT  - Cytogenetics
OT  - cancer
OT  - hematopoietic
OT  - lymphoid
OT  - tumours
EDAT- 2011/10/08 06:00
MHDA- 2011/10/08 06:01
CRDT- 2011/10/08 06:00
PHST- 2011/10/08 06:00 [entrez]
PHST- 2011/10/08 06:00 [pubmed]
PHST- 2011/10/08 06:01 [medline]
AID - 10.3747/co.v18i5.775 [doi]
PST - ppublish
SO  - Curr Oncol. 2011 Oct;18(5):e250-5. doi: 10.3747/co.v18i5.775.


PMID- 21980065
OWN - NLM
STAT- MEDLINE
DCOM- 20120329
LR  - 20120517
IS  - 1460-2091 (Electronic)
IS  - 0305-7453 (Linking)
VI  - 67
IP  - 1
DP  - 2012 Jan
TI  - Ethical dilemmas in antibiotic treatment.
PG  - 12-6
LID - 10.1093/jac/dkr425 [doi]
AB  - Patients with moderate to severe infections are given less than maximum empirical
      antibiotic treatment in order to reduce the rise in resistance. This practice
      involves two ethical dilemmas: whether the danger to a present patient should be 
      increased (even if by a small degree) to benefit future, unidentified patients;
      and whether this should be done without the consent of the patient, disregarding 
      the patient's autonomy. We argue that future patients have a right to come to no 
      harm. Future patients being unidentified, practitioners of medicine have a duty
      to protect their rights and weigh them against the rights of the present patient.
      A decision on the collective (guidelines, decision support systems) is a
      convenient way to do that. Using a temporal discount rate to show that the life
      of present patients has pre-eminence, to some degree, over future patients does
      not solve the immediacy of the plight facing a present, identified patient with a
      very severe infection. We think there are good grounds to take into less account 
      considerations of future resistance for such a patient, or in a formal analysis, 
      to make the ratio of benefits to the present versus future patients dependent on 
      the severity of disease of the present patient. None of these solve the problem
      of patients' autonomy. We see no other way but to argue that the right of future 
      patients to come to less harm outweighs the right of the present patient to share
      in decisions on antibiotic treatment.
FAU - Leibovici, Leonard
AU  - Leibovici L
AD  - Department of Medicine E, Beilinson Hospital, Rabin Medical Center, Petah-Tiqva, 
      Israel. leibovic@post.tau.ac.il
FAU - Paul, Mical
AU  - Paul M
FAU - Ezra, Ovadia
AU  - Ezra O
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111006
PL  - England
TA  - J Antimicrob Chemother
JT  - The Journal of antimicrobial chemotherapy
JID - 7513617
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
CIN - J Antimicrob Chemother. 2012 May;67(5):1302-3. PMID: 22316570
MH  - Anti-Bacterial Agents/*administration & dosage
MH  - Bacteria/*drug effects
MH  - Bacterial Infections/*drug therapy
MH  - *Drug Resistance, Bacterial
MH  - Drug Therapy/*ethics/*methods
MH  - Humans
EDAT- 2011/10/08 06:00
MHDA- 2012/03/30 06:00
CRDT- 2011/10/08 06:00
PHST- 2011/10/08 06:00 [entrez]
PHST- 2011/10/08 06:00 [pubmed]
PHST- 2012/03/30 06:00 [medline]
AID - dkr425 [pii]
AID - 10.1093/jac/dkr425 [doi]
PST - ppublish
SO  - J Antimicrob Chemother. 2012 Jan;67(1):12-6. doi: 10.1093/jac/dkr425. Epub 2011
      Oct 6.


PMID- 21978776
OWN - NLM
STAT- MEDLINE
DCOM- 20111114
LR  - 20111007
IS  - 1214-6994 (Print)
IS  - 1214-6994 (Linking)
VI  - 112
IP  - 3
DP  - 2011
TI  - Yesterday's ethics in contemporary medicine - is it still of concern?
PG  - 159-67
AB  - Discussions on questions and problems of medical ethics are on everyone's lips.
      The debates center for instance around the just allocation of public resources,
      demographical changes in our society or the guarantee of patient autonomy, thus
      posing questions on the technical progress in modern medicine. These contemporary
      conflicts in medicine are numerous, but not all of them are new; rather, the
      discussion in medical ethics on these dilemmas is bound to contexts and has
      historical roots. Some of these conflicts reach back to the medicine of the
      Renaissance and Antiquity, thus assigning actuality to the historical viewpoint. 
      Taking history into account, one can benefit from a timeless content and not
      least get a feeling for historicity and contingency. Considering the creation of 
      identity, the old authorities also represent central normative reference points
      for the ethical competence of physicians understood as an attitude within an
      interpersonal medicine. For this reason, the heritage of Hippocrates, which
      encompasses values and norms of the Hippocratic Oath, needs to be respected.
      Apart from other dimensions of knowledge and skills, the development of an
      individual ethical competence also requires awareness of the past, leading to an 
      understanding for the historical, social and cultural relativity of medical
      action.
FAU - Steger, F
AU  - Steger F
AD  - Institute for Medical History and Ethics, Martin-Luther-Universitat
      Halle-Wittenberg, Halle, Germany. florian.steger@medizin.uni-halle.de
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - Czech Republic
TA  - Prague Med Rep
JT  - Prague medical report
JID - 101227436
SB  - IM
MH  - *Bioethical Issues/history
MH  - *Ethics, Medical/history
MH  - Germany
MH  - History, 15th Century
MH  - History, Ancient
MH  - Humans
MH  - Philosophy, Medical
EDAT- 2011/10/08 06:00
MHDA- 2011/11/15 06:00
CRDT- 2011/10/08 06:00
PHST- 2011/10/08 06:00 [entrez]
PHST- 2011/10/08 06:00 [pubmed]
PHST- 2011/11/15 06:00 [medline]
AID - PMR2011A0017 [pii]
PST - ppublish
SO  - Prague Med Rep. 2011;112(3):159-67.


PMID- 21978348
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20190902
IS  - 1326-5377 (Electronic)
IS  - 0025-729X (Linking)
VI  - 195
IP  - 7
DP  - 2011 Oct 3
TI  - Portrayal of psychiatric genetics in Australian print news media, 1996-2009.
PG  - 401-4
AB  - OBJECTIVE: To investigate how Australian print news media portray psychiatric
      genetics. DESIGN AND SETTING: Content and framing analysis of a structured sample
      of print news items about psychiatric genetics published in Australian newspapers
      between 1996 and 2009. MAIN OUTCOME MEASURES: Identify dominant discourses about 
      aetiology of mental illness, and perceived clinical outcomes and implications of 
      psychiatric genetics research. RESULTS: We analysed 406 eligible items about the 
      genetics of psychiatric disorders. News coverage of psychiatric genetics has
      steadily increased since 1996. Items attributing the aetiology of psychiatric
      disorders to gene-environment interactions (51%) outnumbered items attributing
      only genetic (30%) or only environmental factors (20%). Of items that referred to
      heritability of mental illness, frames of genetic determinism (78%) occurred more
      frequently than probabilistic frames (22%). Of frames related to genetic
      prophesy, genetic optimism frames (78%) were used more frequently than frames of 
      genetic pessimism (22%). Psychosocial and ethical implications of psychiatric
      genetics received comparatively relatively little coverage (23%). The analysis
      identified 22 predictions about psychiatric genetic discoveries and the
      availability of molecular-based interventions in psychiatry, most of which
      (20/22, 91%) failed to manifest by the predicted year. CONCLUSIONS: Excessive
      optimism about the power of genetic technology in psychiatric health care,
      perceived clinical benefits, and largely unfulfilled predictions about
      availability of these benefits could encourage unrealistic expectations about
      future molecular-based treatment options for mental health.
FAU - Wilde, Alex
AU  - Wilde A
AD  - School of Psychiatry, University of New South Wales, Sydney, NSW.
      alex.wilde@unsw.edu.au
FAU - Bonfiglioli, Catriona
AU  - Bonfiglioli C
FAU - Meiser, Bettina
AU  - Meiser B
FAU - Mitchell, Philip B
AU  - Mitchell PB
FAU - Schofield, Peter R
AU  - Schofield PR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Med J Aust
JT  - The Medical journal of Australia
JID - 0400714
SB  - IM
MH  - Australia
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - *Mass Media
MH  - Mental Disorders/*genetics/*therapy
MH  - *Newspapers as Topic
MH  - Public Opinion
MH  - Public Policy
EDAT- 2011/10/08 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/10/08 06:00
PHST- 2011/10/08 06:00 [entrez]
PHST- 2011/10/08 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - wil10167_fm [pii]
AID - 10.5694/mja10.10167 [doi]
PST - ppublish
SO  - Med J Aust. 2011 Oct 3;195(7):401-4. doi: 10.5694/mja10.10167.


PMID- 21977882
OWN - NLM
STAT- MEDLINE
DCOM- 20111123
LR  - 20191112
IS  - 1526-9248 (Print)
IS  - 1526-9248 (Linking)
VI  - 21
IP  - 3
DP  - 2011 Sep
TI  - Kidney paired donation 2011.
PG  - 215-8
AB  - Patients with incompatible live donors have had to resort to the long wait on the
      deceased donor list. Now, through kidney paired donation, these incompatible
      pairs can enter a kidney exchange program where kidneys are "swapped" between
      incompatible pairs. This review highlights the evolution of kidney paired
      exchange and reviews the challenges and ethical considerations within a paired
      exchange system.
FAU - Serur, David
AU  - Serur D
AD  - New York Presbyterian-Weill Cornell Kidney and Pancreas Transplant Program ,The
      Rogosin Institute, New York, NY 10021, USA. dserur@nyp.org
FAU - Charlton, Marian
AU  - Charlton M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Prog Transplant
JT  - Progress in transplantation (Aliso Viejo, Calif.)
JID - 100909380
MH  - Decision Making, Computer-Assisted
MH  - Donor Selection/ethics/*methods
MH  - Histocompatibility
MH  - Humans
MH  - *Kidney Transplantation
MH  - Living Donors/*supply & distribution
MH  - United States
EDAT- 2011/10/08 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/10/08 06:00
PHST- 2011/10/08 06:00 [entrez]
PHST- 2011/10/08 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.7182/prtr.21.3.l040606w00738076 [doi]
PST - ppublish
SO  - Prog Transplant. 2011 Sep;21(3):215-8. doi: 10.7182/prtr.21.3.l040606w00738076.


PMID- 21977066
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120824
LR  - 20220408
IS  - 1998-3557 (Electronic)
IS  - 1998-3557 (Linking)
VI  - 6
IP  - 4
DP  - 2011 Oct
TI  - Development of Arabic version of Berlin questionnaire to identify obstructive
      sleep apnea at risk patients.
PG  - 212-6
LID - 10.4103/1817-1737.84775 [doi]
AB  - BACKGROUND: Obstructive sleep apnea (OSA) is a common, under-recognized, under
      diagnosed, under treated, and serious medical condition in adults.
      Polysomnography (PSG) is the gold standard for diagnosis of OSA; however,
      prohibitive cost of the test and rarity of sleep laboratory in the Arabic nations
      limit its access. So, searching for another simple, economical, reliable, and
      valid tool for identification of OSA at risk patients is of special public
      concern. OBJECTIVE: This study was conducted to evaluate the reliability and
      validity of Arabic version of Berlin questionnaire (ABQ) in detection of OSA at
      risk patients. METHODS: After hospital ethics approval and formal patients
      consent, 100 patients were subjected to full night PSG study after their response
      to the developed ABQ. The patients were classified into both low (30) and high
      risk (70) for OSA using ABQ and validated against apnea hypopnea index (AHI).
      Reliability was assessed by internal consistency using Cronbach's alpha test and 
      consistency over time using test retest correlation. RESULTS: The study
      demonstrated a high degree of internal consistency and stability over time for
      the developed ABQ. The Cronbach's alpha coefficient for the 10-item tool was
      0.92. Validation of ABQ against AHI at cutoff >5 revealed a sensitivity of 97%,
      specificity of 90%, positive and negative predictive values of 96% and 93%,
      respectively. CONCLUSION: The ABQ is reliable and valid scale in screening
      patients for the risk of OSA among Arabic-speaking nations, especially in
      resource-limited settings.
FAU - Saleh, Abdel Baset M
AU  - Saleh AB
AD  - Department of Chest Medicine, Sleep Disordered Breathing Unit and Public Health, 
      Mansoura University, Mansoura, Egypt.
FAU - Ahmad, Magda A
AU  - Ahmad MA
FAU - Awadalla, N J
AU  - Awadalla NJ
LA  - eng
PT  - Journal Article
PL  - India
TA  - Ann Thorac Med
JT  - Annals of thoracic medicine
JID - 101280721
PMC - PMC3183638
OTO - NOTNLM
OT  - Apnea hypopnea index
OT  - Arabic version of Berlin questionnaire
OT  - Berlin questionnaire
OT  - obstructive sleep apnea
OT  - reliability and validity
EDAT- 2011/10/07 06:00
MHDA- 2011/10/07 06:01
CRDT- 2011/10/07 06:00
PHST- 2010/11/22 00:00 [received]
PHST- 2011/04/15 00:00 [accepted]
PHST- 2011/10/07 06:00 [entrez]
PHST- 2011/10/07 06:00 [pubmed]
PHST- 2011/10/07 06:01 [medline]
AID - 10.4103/1817-1737.84775 [doi]
AID - ATM-6-212 [pii]
PST - ppublish
SO  - Ann Thorac Med. 2011 Oct;6(4):212-6. doi: 10.4103/1817-1737.84775.


PMID- 21977041
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1687-9678 (Electronic)
VI  - 2011
DP  - 2011
TI  - Induced pluripotent stem cells in cardiovascular medicine.
PG  - 348960
LID - 10.4061/2011/348960 [doi]
AB  - Induced pluripotent stem (iPS) cells are generated by reprogramming human somatic
      cells through the forced expression of several embryonic stem (ES) cell-specific 
      transcription factors. The potential of iPS cells is having a significant impact 
      on regenerative medicine, with the promise of infinite self-renewal,
      differentiation into multiple cell types, and no problems concerning ethics or
      immunological rejection. Human iPS cells are currently generated by transgene
      introduction principally through viral vectors, which integrate into host
      genomes, although the associated risk of tumorigenesis is driving research into
      nonintegration methods. Techniques for pluripotent stem cell differentiation and 
      purification to yield cardiomyocytes are also advancing constantly. Although
      there remain some unsolved problems, cardiomyocyte transplantation may be a
      reality in the future. After those problems will be solved, applications of human
      iPS cells in human cardiovascular regenerative medicine will be envisaged for the
      future. Furthermore, iPS cell technology has generated new human disease models
      using disease-specific cells. This paper summarizes the progress of iPS cell
      technology in cardiovascular research.
FAU - Egashira, Toru
AU  - Egashira T
AD  - Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi,
      Shinjuku, Tokyo 160-8582, Japan.
FAU - Yuasa, Shinsuke
AU  - Yuasa S
FAU - Fukuda, Keiichi
AU  - Fukuda K
LA  - eng
PT  - Journal Article
DEP - 20111002
PL  - United States
TA  - Stem Cells Int
JT  - Stem cells international
JID - 101535822
PMC - PMC3184500
EDAT- 2011/10/07 06:00
MHDA- 2011/10/07 06:01
CRDT- 2011/10/07 06:00
PHST- 2010/12/22 00:00 [received]
PHST- 2011/05/25 00:00 [revised]
PHST- 2011/07/18 00:00 [accepted]
PHST- 2011/10/07 06:00 [entrez]
PHST- 2011/10/07 06:00 [pubmed]
PHST- 2011/10/07 06:01 [medline]
AID - 10.4061/2011/348960 [doi]
PST - ppublish
SO  - Stem Cells Int. 2011;2011:348960. doi: 10.4061/2011/348960. Epub 2011 Oct 2.


PMID- 21975838
OWN - NLM
STAT- MEDLINE
DCOM- 20120628
LR  - 20211020
IS  - 2193-6226 (Electronic)
IS  - 2193-6218 (Linking)
VI  - 106
IP  - 1
DP  - 2011 Sep
TI  - [Geriatric patients in intensive care medicine. Ethical aspects].
PG  - 24-8
LID - 10.1007/s00063-011-0022-9 [doi]
AB  - Due to demographic change and progress in medicine, the percentage of geriatric
      patients treated in intensive care is continuously increasing. In addition to the
      acute disease, many of these patients may also have chronic illnesses,
      multimorbidity, and cognitive limitations. In view of these conditions, it might 
      become questionable whether intensive care treatment is medically and
      economically justifiable and really in the interest of the patient. From an
      ethical perspective, age might indeed be a factor to consider when making a
      decision about initiating or continuing intensive care treatment in an individual
      case. The denial of access to intensive care, however, cannot be justified by the
      advanced age of the patient alone. This would display an ethically problematic
      form of discrimination (ageism).
FAU - Simon, A
AU  - Simon A
AD  - Akademie fur Ethik in der Medizin e.V., Gottingen, Deutschland.
      simon@aem-online.de
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Alte Patienten in der Intensivmedizin. Ethische Aspekte.
DEP - 20111007
PL  - Germany
TA  - Med Klin Intensivmed Notfmed
JT  - Medizinische Klinik, Intensivmedizin und Notfallmedizin
JID - 101575086
SB  - IM
MH  - Advance Directives/ethics
MH  - Aged
MH  - Aged, 80 and over
MH  - Critical Care/*ethics
MH  - *Ethics, Medical
MH  - Germany
MH  - Health Care Rationing/*ethics
MH  - Health Services Accessibility/ethics
MH  - Humans
MH  - Medical Futility/ethics
MH  - *Population Dynamics
MH  - Prejudice
EDAT- 2011/10/07 06:00
MHDA- 2012/06/29 06:00
CRDT- 2011/10/07 06:00
PHST- 2011/06/10 00:00 [received]
PHST- 2011/07/22 00:00 [accepted]
PHST- 2011/10/07 06:00 [entrez]
PHST- 2011/10/07 06:00 [pubmed]
PHST- 2012/06/29 06:00 [medline]
AID - 10.1007/s00063-011-0022-9 [doi]
PST - ppublish
SO  - Med Klin Intensivmed Notfmed. 2011 Sep;106(1):24-8. doi:
      10.1007/s00063-011-0022-9. Epub 2011 Oct 7.


PMID- 21975476
OWN - NLM
STAT- MEDLINE
DCOM- 20120217
LR  - 20111006
IS  - 1552-7409 (Electronic)
IS  - 0894-3184 (Linking)
VI  - 24
IP  - 4
DP  - 2011 Oct
TI  - Conceptual development of an instrument to measure the internalized stigma of
      AIDS based on the Roy adaptation model.
PG  - 306-10
LID - 10.1177/0894318411419222 [doi]
AB  - In this column the author describes the development of an instrument to measure
      internalized stigma of HIV/AIDS based on the self-concept adaptive mode of the
      Roy adaptation model. The Internalized Stigma of AIDS Tool is a 10-item
      instrument that is derived from the physical self (body sensation and image) and 
      personal self (self-consistency, self-ideal and moral-ethical-spiritual self) as 
      set forth by Roy. An overview of the Roy adaptation model and the theory of the
      person as an adaptive system illustrates how this instrument was derived.
FAU - Phillips, Kenneth D
AU  - Phillips KD
AD  - The University of Tennessee-Knoxville, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Nurs Sci Q
JT  - Nursing science quarterly
JID - 8805022
MH  - Adaptation, Psychological
MH  - HIV Infections/nursing/*psychology
MH  - Humans
MH  - *Internal-External Control
MH  - *Models, Nursing
MH  - Models, Psychological
MH  - Nursing Theory
MH  - Psychometrics
MH  - *Self Concept
MH  - *Stereotyping
EDAT- 2011/10/07 06:00
MHDA- 2012/02/18 06:00
CRDT- 2011/10/07 06:00
PHST- 2011/10/07 06:00 [entrez]
PHST- 2011/10/07 06:00 [pubmed]
PHST- 2012/02/18 06:00 [medline]
AID - 24/4/306 [pii]
AID - 10.1177/0894318411419222 [doi]
PST - ppublish
SO  - Nurs Sci Q. 2011 Oct;24(4):306-10. doi: 10.1177/0894318411419222.


PMID- 21975285
OWN - NLM
STAT- MEDLINE
DCOM- 20120816
LR  - 20211020
IS  - 1873-2054 (Electronic)
IS  - 1353-8292 (Linking)
VI  - 18
IP  - 2
DP  - 2012 Mar
TI  - Building adherence-competent communities: factors promoting children's adherence 
      to anti-retroviral HIV/AIDS treatment in rural Zimbabwe.
PG  - 123-31
LID - 10.1016/j.healthplace.2011.07.008 [doi]
AB  - Given relatively high levels of adherence to HIV treatment in Africa, we explore 
      factors facilitating children's adherence, despite poverty, social disruption and
      limited health infrastructure. Using interviews with 25 nurses and 40 guardians
      in Zimbabwe, we develop our conceptualisation of an 'adherence competent
      community', showing how members of five networks (children, guardians, community 
      members, health workers and NGOs) have taken advantage of the gradual public
      normalisation of HIV/AIDS and improved drug and service availability to construct
      new norms of solidarity with HIV and AIDS sufferers, recognition of HIV-infected 
      children's social worth, an ethic of care/assistance and a supporting atmosphere 
      of enablement/empowerment.
CI  - Copyright (c) 2011. Published by Elsevier Ltd.
FAU - Campbell, Catherine
AU  - Campbell C
AD  - Institute of Social Psychology, London School of Economics and Political Science,
      London, UK. c.campbell@lse.ac.uk
FAU - Skovdal, Morten
AU  - Skovdal M
FAU - Mupambireyi, Zivai
AU  - Mupambireyi Z
FAU - Madanhire, Claudius
AU  - Madanhire C
FAU - Nyamukapa, Constance
AU  - Nyamukapa C
FAU - Gregson, Simon
AU  - Gregson S
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110914
PL  - England
TA  - Health Place
JT  - Health & place
JID - 9510067
RN  - 0 (Anti-Retroviral Agents)
MH  - Adolescent
MH  - Anti-Retroviral Agents/*therapeutic use
MH  - Child
MH  - Child, Preschool
MH  - HIV Infections/*drug therapy
MH  - Health Promotion
MH  - Humans
MH  - Infant
MH  - Interviews as Topic
MH  - *Patient Compliance
MH  - *Rural Population
MH  - Social Support
MH  - Young Adult
MH  - Zimbabwe
PMC - PMC3512054
EDAT- 2011/10/07 06:00
MHDA- 2012/08/17 06:00
CRDT- 2011/10/07 06:00
PHST- 2010/12/07 00:00 [received]
PHST- 2011/07/06 00:00 [revised]
PHST- 2011/07/18 00:00 [accepted]
PHST- 2011/10/07 06:00 [entrez]
PHST- 2011/10/07 06:00 [pubmed]
PHST- 2012/08/17 06:00 [medline]
AID - S1353-8292(11)00124-9 [pii]
AID - 10.1016/j.healthplace.2011.07.008 [doi]
PST - ppublish
SO  - Health Place. 2012 Mar;18(2):123-31. doi: 10.1016/j.healthplace.2011.07.008. Epub
      2011 Sep 14.


PMID- 21975224
OWN - NLM
STAT- MEDLINE
DCOM- 20120306
LR  - 20111107
IS  - 1472-6491 (Electronic)
IS  - 1472-6483 (Linking)
VI  - 23
IP  - 5
DP  - 2011 Nov
TI  - Reproduction opportunists in the new global sex trade: PGD and non-medical sex
      selection.
PG  - 609-17
LID - 10.1016/j.rbmo.2011.06.017 [doi]
AB  - Regulatory differences between countries are an important driver of the
      cross-border trade in assisted reproduction as people move to seek services
      unavailable in their home countries. The development of a lucrative global trade 
      in non-medical sex selection needs to be considered in ethical debates over its
      availability. I suggest that depictions of non-medical sex selection as a means
      of 'family balancing' or supportive of reproductive autonomy serve to distance
      the technologies rhetorically from the gender stereotyping inherent in their use 
      and the commodification upon which they depend. They construct new social
      categories such as the 'unbalanced' family, the pathologization of 'gender
      disappointment' and a limited and highly individualized definition of
      reproductive freedom that permits medical interventions on healthy bodies.
      Orientalism pervades ethical debate depicting non-medical sex selection in the
      West as more acceptable to practices in 'Asia'. A case study of the
      interconnections between Australia and Thailand highlights the global economy
      sustaining the practice.
CI  - Copyright (c) 2011 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All
      rights reserved.
FAU - Whittaker, Andrea M
AU  - Whittaker AM
AD  - School of Population Health, University of Queensland, Public Health Building,
      Herston, Queensland. 4006, Australia. a.whittaker2@uq.edu.au
LA  - eng
PT  - Journal Article
DEP - 20110707
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
SB  - IM
MH  - Australia
MH  - *Commodification
MH  - Female
MH  - Humans
MH  - Medical Tourism/*trends
MH  - Pregnancy
MH  - Preimplantation Diagnosis/methods/*trends
MH  - Prejudice
MH  - Reproductive Rights/ethics/*legislation & jurisprudence
MH  - Sex Preselection/*ethics/*legislation & jurisprudence/methods
MH  - Thailand
EDAT- 2011/10/07 06:00
MHDA- 2012/03/07 06:00
CRDT- 2011/10/07 06:00
PHST- 2011/03/07 00:00 [received]
PHST- 2011/05/06 00:00 [revised]
PHST- 2011/06/27 00:00 [accepted]
PHST- 2011/10/07 06:00 [entrez]
PHST- 2011/10/07 06:00 [pubmed]
PHST- 2012/03/07 06:00 [medline]
AID - S1472-6483(11)00361-0 [pii]
AID - 10.1016/j.rbmo.2011.06.017 [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2011 Nov;23(5):609-17. doi: 10.1016/j.rbmo.2011.06.017.
      Epub 2011 Jul 7.


PMID- 21975207
OWN - NLM
STAT- MEDLINE
DCOM- 20120209
LR  - 20211020
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Linking)
VI  - 77
IP  - 24
DP  - 2011 Dec 13
TI  - Effect of public deliberation on attitudes toward surrogate consent for dementia 
      research.
PG  - 2097-104
LID - 10.1212/WNL.0b013e31823648cb [doi]
AB  - OBJECTIVE: To assess the informed, deliberative views of the older general public
      toward a policy of allowing surrogate consent for Alzheimer disease (AD)
      research. METHODS: A total of 503 persons aged 50+ recruited by random digit
      dialing were randomly assigned to 1 of 3 groups: deliberation, education, or
      control. The deliberation group attended an all-day education/peer deliberation
      session; the education group received written information only. Participants were
      surveyed at baseline, after deliberation session (or equivalent time), and 1
      month after the session, regarding their attitudes toward a policy of allowing
      surrogate consent for research studies of varying risks and potential benefits (a
      lumbar puncture study, a drug randomized controlled trial, a vaccine randomized
      controlled trial, and an early phase gene transfer trial). RESULTS: At baseline, 
      a policy of surrogate consent for AD research was supported by 55%-91%, depending
      on the scenario. The education group had a transient increase in support for one 
      research scenario after receiving the information materials. In the deliberation 
      group, support for surrogate consent was higher after deliberation for all
      scenarios (67% to 97%), with much of the increase sustained 1 month after the
      deliberation session. No changes occurred in the control group. The study's
      limitations include self-selection of participants due to the demanding nature of
      attendance at the deliberation sessions. CONCLUSIONS: This sample of the older
      general public generally supported a policy of surrogate consent for AD research 
      at baseline. Their support increased with democratic deliberation involving
      informed, in-depth exploration of the relevant scientific and ethical issues.
FAU - Kim, S Y H
AU  - Kim SY
AD  - Center for Bioethics and Social Sciences in Medicine, University of Michigan, Ann
      Arbor 48109, USA.
FAU - Kim, H M
AU  - Kim HM
FAU - Knopman, D S
AU  - Knopman DS
FAU - De Vries, R
AU  - De Vries R
FAU - Damschroder, L
AU  - Damschroder L
FAU - Appelbaum, P S
AU  - Appelbaum PS
LA  - eng
GR  - R01AG029550/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20111005
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/*therapy
MH  - *Attitude
MH  - *Ethics, Research
MH  - Female
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Male
MH  - *Mental Competency
MH  - Middle Aged
MH  - Randomized Controlled Trials as Topic/*ethics
PMC - PMC3235352
EDAT- 2011/10/07 06:00
MHDA- 2012/02/10 06:00
CRDT- 2011/10/07 06:00
PHST- 2011/10/07 06:00 [entrez]
PHST- 2011/10/07 06:00 [pubmed]
PHST- 2012/02/10 06:00 [medline]
AID - WNL.0b013e31823648cb [pii]
AID - 10.1212/WNL.0b013e31823648cb [doi]
PST - ppublish
SO  - Neurology. 2011 Dec 13;77(24):2097-104. doi: 10.1212/WNL.0b013e31823648cb. Epub
      2011 Oct 5.


PMID- 21975135
OWN - NLM
STAT- MEDLINE
DCOM- 20120426
LR  - 20181201
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 136
IP  - 1-2
DP  - 2012 Jan
TI  - Impact on prisoners of participating in research interviews related to
      near-lethal suicide attempts.
PG  - 54-62
LID - S0165-0327(11)00535-0 [pii]
LID - 10.1016/j.jad.2011.09.009 [doi]
AB  - BACKGROUND: Prisoners have a high risk of suicide. Research studies have
      investigated factors contributing to this, some through interviews with survivors
      of suicide attempts, others with informants such as family and friends of suicide
      victims. However, there is little information regarding the effects of
      participating in such interviews. AIMS: To investigate the effects on
      participants of taking part in detailed interviews about suicidal behaviour and
      contributory factors. METHOD: Case-control studies of 120 prisoners who made
      near-lethal suicide attempts (cases) and 120 prisoners who had never carried out 
      near-lethal suicide attempts in prison (controls) were conducted. Information
      regarding effects on prisoners of participating in the interviews was collected
      using quantitative and qualitative methods. RESULTS: For both male cases and
      controls, and female controls, self-reported mood levels improved significantly
      by the end of the interviews. For female cases, the interviews had no negative
      effect on their self-reported mood. Whilst some prisoners found the interviews
      upsetting, nearly all said they were pleased to have participated. LIMITATIONS:
      The same researchers carried out the interviews and collected data on the effects
      of participation. Also, several potential participants were excluded from the
      study and the likely effect of the interview on them is unknown. CONCLUSIONS: We 
      found little evidence that participation of prisoners in interview-based research
      on suicidal behaviour has negative effects on them; indeed, it can be beneficial.
      Inclusion of similar instruments to measure the effects of research participation
      in future investigations could provide valuable feedback to researchers and
      ethics committees.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Rivlin, Adrienne
AU  - Rivlin A
AD  - Centre for Suicide Research, Department of Psychiatry, University of Oxford,
      United Kingdom.
FAU - Marzano, Lisa
AU  - Marzano L
AD  - Centre for Suicide Research, Department of Psychiatry, University of Oxford,
      United Kingdom.
FAU - Hawton, Keith
AU  - Hawton K
AD  - Centre for Suicide Research, Department of Psychiatry, University of Oxford,
      United Kingdom. Electronic address: keith.hawton@psych.ox.ac.uk.
FAU - Fazel, Seena
AU  - Fazel S
AD  - Centre for Suicide Research, Department of Psychiatry, University of Oxford,
      United Kingdom.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111004
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - *Interview, Psychological
MH  - Male
MH  - Prisoners/*psychology
MH  - Stress, Psychological
MH  - Suicide, Attempted/*psychology
MH  - Young Adult
EDAT- 2011/10/07 06:00
MHDA- 2012/04/27 06:00
CRDT- 2011/10/07 06:00
PHST- 2010/12/08 00:00 [received]
PHST- 2011/07/13 00:00 [revised]
PHST- 2011/09/07 00:00 [accepted]
PHST- 2011/10/07 06:00 [entrez]
PHST- 2011/10/07 06:00 [pubmed]
PHST- 2012/04/27 06:00 [medline]
AID - S0165-0327(11)00535-0 [pii]
AID - 10.1016/j.jad.2011.09.009 [doi]
PST - ppublish
SO  - J Affect Disord. 2012 Jan;136(1-2):54-62. doi: 10.1016/j.jad.2011.09.009. Epub
      2011 Oct 4.


PMID- 21974944
OWN - NLM
STAT- MEDLINE
DCOM- 20120319
LR  - 20111130
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 6
DP  - 2011 Nov
TI  - Orthodox Jewish perspectives on withholding and withdrawing life-sustaining
      treatment.
PG  - 835-46
LID - 10.1177/0969733011408051 [doi]
AB  - The Jewish religious tradition summons its adherents to save life. For religious 
      Jews preservation of life is the ultimate religious commandment. At the same time
      Jewish law recognizes that the agony of a moribund person may not be stretched.
      When the time to die has come this has to be respected. The process of dying
      should not needlessly be prolonged. We discuss the position of two prominent
      Orthodox Jewish authorities - the late Rabbi Moshe Feinstein and Rabbi J David
      Bleich - towards the role of life-sustaining treatment in end-of-life care. From 
      the review, the characteristic halachic and heterogeneous character of Jewish
      ethical reasoning appears. The specificity of Jewish dealing with ethical
      dilemmas in health care indicates the importance for contemporary healthcare
      professionals of providing care which is sensitive to a patient's culture and
      worldview.
FAU - Baeke, Goedele
AU  - Baeke G
AD  - Faculty of Theology (Interdisciplinary Centre for the Study of Religion and World
      View), Katholieke Universiteit Leuven, Leuven, Belgium.
      Goedele.Baeke@theo.kuleuven.be
FAU - Wils, Jean-Pierre
AU  - Wils JP
FAU - Broeckaert, Bert
AU  - Broeckaert B
LA  - eng
PT  - Journal Article
DEP - 20111005
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Cultural Characteristics
MH  - Humans
MH  - *Judaism
MH  - Life Support Care/*ethics
MH  - *Religion and Medicine
MH  - Withholding Treatment/*ethics
EDAT- 2011/10/07 06:00
MHDA- 2012/03/20 06:00
CRDT- 2011/10/07 06:00
PHST- 2011/10/07 06:00 [entrez]
PHST- 2011/10/07 06:00 [pubmed]
PHST- 2012/03/20 06:00 [medline]
AID - 0969733011408051 [pii]
AID - 10.1177/0969733011408051 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Nov;18(6):835-46. doi: 10.1177/0969733011408051. Epub 2011 Oct 
      5.


PMID- 21974943
OWN - NLM
STAT- MEDLINE
DCOM- 20120319
LR  - 20191210
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 6
DP  - 2011 Nov
TI  - Frequency and burden with ethical conflicts and burnout in nurses.
PG  - 847-61
LID - 10.1177/0969733011408053 [doi]
AB  - Many studies examine a stressors-professional burnout (PB) relation, but only few
      consider the role of ethical conflicts (ECs) in this context. The aim of this
      study was to characterize ECs' frequency and level of burden with them among
      nurses and to establish the relations between ECs' frequency, burden and PB. One 
      hundred nurses participated in this study. ECs' frequency and burden were tested 
      with an originally developed questionnaire. PB was examined with Maslach Burnout 
      Inventory. Most frequent ECs concerned a nurse-patient relationship. PB was
      positively related to ECs' frequency (r = .54; p = .001) and burden (r = .22; p =
      .03). Frequency of specific conflict did not imply burden with it and vice versa.
      ECs' frequency seems more important for PB than a level of burden with them. The 
      most frequent and the most burdening conflicts may lead to development of PB but 
      the less frequent and less burdening ones are also dangerous.
FAU - Wlodarczyk, Dorota
AU  - Wlodarczyk D
AD  - Department of Medical Psychology, Medical University of Warsaw, Warsaw, Poland.
      dorota@wde.com.pl
FAU - Lazarewicz, Magdalena
AU  - Lazarewicz M
LA  - eng
PT  - Journal Article
DEP - 20111005
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Adult
MH  - Burnout, Professional/*etiology
MH  - *Conflict, Psychological
MH  - *Ethics, Nursing
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nursing Methodology Research
MH  - Nursing Staff, Hospital/*psychology
MH  - Young Adult
EDAT- 2011/10/07 06:00
MHDA- 2012/03/20 06:00
CRDT- 2011/10/07 06:00
PHST- 2011/10/07 06:00 [entrez]
PHST- 2011/10/07 06:00 [pubmed]
PHST- 2012/03/20 06:00 [medline]
AID - 0969733011408053 [pii]
AID - 10.1177/0969733011408053 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Nov;18(6):847-61. doi: 10.1177/0969733011408053. Epub 2011 Oct 
      5.


PMID- 21974942
OWN - NLM
STAT- MEDLINE
DCOM- 20120319
LR  - 20220318
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 6
DP  - 2011 Nov
TI  - Changes in how ICU nurses perceive the DNR decision and their nursing activity
      after implementing it.
PG  - 802-13
LID - 10.1177/0969733011410093 [doi]
AB  - This study investigated the perceptions and attitudes of ICU nurses towards the
      'do not resuscitate' (DNR) decision and changes in their nursing activities after
      implementation of the DNR decision in South Korea. A data survey was conducted in
      South Korea between August and October 2008, with a convenience sample of 252 ICU
      nurses who had more than one year of clinical experience. The data were collected
      via a self-administered questionnaire. Most of the nurses perceived the necessity
      of the DNR decision in cases where there would be no chance of patient recovery
      despite massive efforts. Very few of the nurses' activities changed, either
      passively or actively, after implementation of the DNR decision. Moreover, the
      findings of this research provide suggestions for the future direction of the DNR
      decision and ethical nursing guidelines in South Korea. Further investigations
      are needed for the development of decision-making skills and intervention
      guidelines for end-of-life nursing.
FAU - Park, Young-Rye
AU  - Park YR
AD  - Kunsan National University, Republic of Korea.
FAU - Kim, Jin-A
AU  - Kim JA
FAU - Kim, Kisook
AU  - Kim K
LA  - eng
PT  - Journal Article
DEP - 20111005
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Critical Care/*psychology
MH  - Decision Making
MH  - Humans
MH  - Intensive Care Units
MH  - Nursing Methodology Research
MH  - Nursing Staff, Hospital/*psychology/statistics & numerical data
MH  - Practice Guidelines as Topic
MH  - *Practice Patterns, Nurses'
MH  - Republic of Korea
MH  - Resuscitation Orders/ethics/*psychology
MH  - Young Adult
EDAT- 2011/10/07 06:00
MHDA- 2012/03/20 06:00
CRDT- 2011/10/07 06:00
PHST- 2011/10/07 06:00 [entrez]
PHST- 2011/10/07 06:00 [pubmed]
PHST- 2012/03/20 06:00 [medline]
AID - 0969733011410093 [pii]
AID - 10.1177/0969733011410093 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Nov;18(6):802-13. doi: 10.1177/0969733011410093. Epub 2011 Oct 
      5.


PMID- 21974941
OWN - NLM
STAT- MEDLINE
DCOM- 20120319
LR  - 20191210
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 6
DP  - 2011 Nov
TI  - Operational conditions: legal capacity of a patient soldier refusing medical
      treatment.
PG  - 825-34
LID - 10.1177/0969733011408044 [doi]
AB  - Using a three-dimensional ethical role-specific model, this article considers the
      dual loyalty conflict between following military orders and professional codes of
      practice in an operational military environment when a patient soldier refuses
      life-saving medical treatment and where their legal capacity is questionable. The
      article suggests that although every competent patient has the right to refuse
      medical treatment even though they may die as a consequence. Ordinarily, it is
      unethical to exert any undue influence on a patient to accept medical treatment, 
      in a military operational environment where attack from the enemy is likely, it
      may be reasonable and understandable to exert undue influence over a patient when
      they lack legal capacity.
FAU - Kelly, Janet C
AU  - Kelly JC
AD  - Department of Professional Health Studies,University of Hull, UK.
      j.kelly@hull.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20111005
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Codes of Ethics
MH  - *Conflict, Psychological
MH  - Decision Making
MH  - Hierarchy, Social
MH  - Humans
MH  - Mental Competency/*legislation & jurisprudence
MH  - Military Medicine/*ethics
MH  - Military Personnel/*psychology
MH  - Models, Psychological
MH  - Treatment Refusal/*psychology
EDAT- 2011/10/07 06:00
MHDA- 2012/03/20 06:00
CRDT- 2011/10/07 06:00
PHST- 2011/10/07 06:00 [entrez]
PHST- 2011/10/07 06:00 [pubmed]
PHST- 2012/03/20 06:00 [medline]
AID - 0969733011408044 [pii]
AID - 10.1177/0969733011408044 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Nov;18(6):825-34. doi: 10.1177/0969733011408044. Epub 2011 Oct 
      5.


PMID- 21974940
OWN - NLM
STAT- MEDLINE
DCOM- 20120319
LR  - 20191210
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 6
DP  - 2011 Nov
TI  - Ethical conflicts with hospitals: the perspective of nurses and physicians.
PG  - 756-66
LID - 10.1177/0969733011401121 [doi]
AB  - Nurses and physicians may experience ethical conflict when there is a difference 
      between their own values, their professional values or the values of their
      organization. The distribution of limited health care resources can be a major
      source of ethical conflict. Relatively few studies have examined nurses' and
      physicians' ethical conflict with organizations. This study examined the research
      question 'What are the organizational ethical conflicts that hospital nurses and 
      physicians experience in their practice?' We interviewed 34 registered nurses, 10
      nurse managers, and 31 physicians as part of a larger study, and asked them to
      describe their ethical conflicts with organizations. Through content analysis, we
      identified themes of nurses' and physicians' ethical conflict with organizations 
      and compared the themes for nurses with those for physicians.
FAU - Gaudine, Alice
AU  - Gaudine A
AD  - School of Nursing,Memorial University of Newfoundland, St. John's, Newfoundland, 
      Canada. agaudine@mun.ca
FAU - LeFort, Sandra M
AU  - LeFort SM
FAU - Lamb, Marianne
AU  - Lamb M
FAU - Thorne, Linda
AU  - Thorne L
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111005
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - *Attitude of Health Personnel
MH  - Canada
MH  - *Conflict, Psychological
MH  - Ethics, Medical
MH  - Ethics, Nursing
MH  - Hospital Administration/*ethics
MH  - Hospital-Physician Relations
MH  - Humans
MH  - Medical Staff, Hospital/*ethics/psychology
MH  - Nursing Methodology Research
MH  - Nursing Staff, Hospital/*ethics/psychology
MH  - Qualitative Research
MH  - Social Values
EDAT- 2011/10/07 06:00
MHDA- 2012/03/20 06:00
CRDT- 2011/10/07 06:00
PHST- 2011/10/07 06:00 [entrez]
PHST- 2011/10/07 06:00 [pubmed]
PHST- 2012/03/20 06:00 [medline]
AID - 0969733011401121 [pii]
AID - 10.1177/0969733011401121 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Nov;18(6):756-66. doi: 10.1177/0969733011401121. Epub 2011 Oct 
      5.


PMID- 21973256
OWN - NLM
STAT- MEDLINE
DCOM- 20111123
LR  - 20191210
IS  - 1753-6405 (Electronic)
IS  - 1326-0200 (Linking)
VI  - 35
IP  - 5
DP  - 2011 Oct
TI  - Development and validation of reporting guidelines for studies involving data
      linkage.
PG  - 486-9
LID - 10.1111/j.1753-6405.2011.00741.x [doi]
AB  - OBJECTIVE: Data or record linkage is commonly used to combine existing data sets 
      for the purpose of creating more comprehensive information to conduct research.
      Linked data may create additional concerns about error if cases are not linked
      accurately. It is important that factors compromising the quality of studies
      using linked data be reported in a clear and consistent way that allows readers
      and researchers to accurately appraise the results. The aim of this study was to 
      develop and test reporting guidelines for evaluating the methodological quality
      of studies using linked data. METHOD: The development process included a
      literature review, a Delphi process and a validation process. Participants in the
      process were all Australian and included biostatisticians, epidemiologists,
      registry administrators, academic clinicians and a peer-reviewed journal editor. 
      RESULTS: The final guidelines included four domains and 14 reporting items. These
      included: data sources (six items), research selected variables (four items),
      linkage technology and data analysis (three items), and ethics, privacy and data 
      security (one item). CONCLUSION: This study is the first to develop guidelines
      for appraising the quality of reported data linkage studies. IMPLICATIONS: These 
      guidelines will assist authors to report their results in a consistent,
      high-quality manner. They will also assist readers to interpret the quality of
      results derived from data linkage studies.
CI  - (c) 2011 The Authors. ANZJPH (c) 2011 Public Health Association of Australia.
FAU - Bohensky, Megan A
AU  - Bohensky MA
AD  - Centre for Research Excellence in Patient Safety, Department of Epidemiology &
      Preventive Medicine, Monash University, 99 Commercial Road, Prahran, Victoria
      3181. megan.bohensky@monash.edu
FAU - Jolley, Damien
AU  - Jolley D
FAU - Sundararajan, Vijaya
AU  - Sundararajan V
FAU - Evans, Sue
AU  - Evans S
FAU - Ibrahim, Joseph
AU  - Ibrahim J
FAU - Brand, Caroline
AU  - Brand C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20110912
PL  - Australia
TA  - Aust N Z J Public Health
JT  - Australian and New Zealand journal of public health
JID - 9611095
SB  - IM
MH  - Australia
MH  - *Biomedical Research
MH  - Guidelines as Topic
MH  - Humans
MH  - Medical Record Linkage/*standards
MH  - Peer Review, Research
MH  - Research Design/*standards
MH  - Research Report/*standards
EDAT- 2011/10/07 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/10/07 06:00
PHST- 2011/10/07 06:00 [entrez]
PHST- 2011/10/07 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1111/j.1753-6405.2011.00741.x [doi]
PST - ppublish
SO  - Aust N Z J Public Health. 2011 Oct;35(5):486-9. doi:
      10.1111/j.1753-6405.2011.00741.x. Epub 2011 Sep 12.


PMID- 21973253
OWN - NLM
STAT- MEDLINE
DCOM- 20111123
LR  - 20120731
IS  - 1753-6405 (Electronic)
IS  - 1326-0200 (Linking)
VI  - 35
IP  - 5
DP  - 2011 Oct
TI  - Not a surgical vaccine: there is no case for boosting infant male circumcision to
      combat heterosexual transmission of HIV in Australia.
PG  - 459-65
LID - 10.1111/j.1753-6405.2011.00761.x [doi]
AB  - OBJECTIVE: To conduct a critical review of recent proposals that widespread
      circumcision of male infants be introduced in Australia as a means of combating
      heterosexually transmitted HIV infection. APPROACH: These arguments are evaluated
      in terms of their logic, coherence and fidelity to the principles of
      evidence-based medicine; the extent to which they take account of the evidence
      for circumcision having a protective effect against HIV and the practicality of
      circumcision as an HIV control strategy; the extent of its applicability to the
      specifics of Australia's HIV epidemic; the benefits, harms and risks of
      circumcision; and the associated human rights, bioethical and legal issues.
      CONCLUSION: Our conclusion is that such proposals ignore doubts about the
      robustness of the evidence from the African random-controlled trials as to the
      protective effect of circumcision and the practical value of circumcision as a
      means of HIV control; misrepresent the nature of Australia's HIV epidemic and
      exaggerate the relevance of the African random-controlled trials findings to it; 
      underestimate the risks and harm of circumcision; and ignore questions of medical
      ethics and human rights. The notion of circumcision as a 'surgical vaccine' is
      criticised as polemical and unscientific. IMPLICATIONS: Circumcision of infants
      or other minors has no place among HIV control measures in the Australian and New
      Zealand context; proposals such as these should be rejected.
CI  - (c) 2011 The Authors. ANZJPH (c) 2011 Public Health Association of Australia.
FAU - Darby, Robert
AU  - Darby R
AD  - Australian Capital Territory.
FAU - Van Howe, Robert
AU  - Van Howe R
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Australia
TA  - Aust N Z J Public Health
JT  - Australian and New Zealand journal of public health
JID - 9611095
SB  - IM
CIN - Aust N Z J Public Health. 2012 Jun;36(3):293-4; author reply 294-5. PMID:
      22672040
MH  - Australia
MH  - *Circumcision, Male
MH  - Evidence-Based Medicine
MH  - HIV Infections/*prevention & control/transmission
MH  - *Heterosexuality
MH  - Humans
MH  - Male
MH  - Randomized Controlled Trials as Topic
MH  - Sexually Transmitted Diseases/prevention & control/transmission
EDAT- 2011/10/07 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/10/07 06:00
PHST- 2011/10/07 06:00 [entrez]
PHST- 2011/10/07 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1111/j.1753-6405.2011.00761.x [doi]
PST - ppublish
SO  - Aust N Z J Public Health. 2011 Oct;35(5):459-65. doi:
      10.1111/j.1753-6405.2011.00761.x.


PMID- 21972488
OWN - NLM
STAT- MEDLINE
DCOM- 20111102
LR  - 20191210
IS  - 1020-3397 (Print)
IS  - 1020-3397 (Linking)
VI  - 17
IP  - 7
DP  - 2011 Jul
TI  - Ethics of medical care for body packers (drug smugglers): untangling a web of
      fears and conflicts of interest.
PG  - 624-9
AB  - Body packing by drug smugglers--the transport of illicit drugs in packets
      swallowed or inserted into body cavities--is a global phenomenon and is becoming 
      more prevalent. The medical care of these patients raises difficult medical and
      ethical problems. While the medical aspects of treating body packers have been
      systematically analysed, the ethical issues have received little attention in the
      literature. The patient may be under police custody or being sought by their
      criminal patron which may result in imposed interrogations and risky medical
      procedures. Obtaining informed valid consent for procedures from the
      patient-detainee may thus be compromised. In addition, physicians may be
      intimidated by the patient's criminal contacts. This article analyses the
      conflicts of interest that doctors may face when treating body packers, and
      proposes some principles to promote institutional guidelines for the treatment of
      these patients.
FAU - Baljevic, M
AU  - Baljevic M
AD  - Department of Public Health, Division of Medical Ethics, Weill Cornell Medical
      College, Doha, Qatar. mub2004@qatar-med.cornell.edu
FAU - Rodriguez del Pozo, P
AU  - Rodriguez del Pozo P
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Egypt
TA  - East Mediterr Health J
JT  - Eastern Mediterranean health journal = La revue de sante de la Mediterranee
      orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit
JID - 9608387
RN  - 0 (Illicit Drugs)
SB  - IM
MH  - *Conflict of Interest
MH  - *Ethics, Medical
MH  - Foreign Bodies/complications/*therapy
MH  - Gastrointestinal Diseases/etiology/*therapy
MH  - Humans
MH  - *Illicit Drugs
EDAT- 2011/10/07 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/10/07 06:00
PHST- 2011/10/07 06:00 [entrez]
PHST- 2011/10/07 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
PST - ppublish
SO  - East Mediterr Health J. 2011 Jul;17(7):624-9.


PMID- 21972250
OWN - NLM
STAT- MEDLINE
DCOM- 20120524
LR  - 20171116
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 3
DP  - 2012 Mar
TI  - Testing relationships: ethical arguments for screening for type 2 diabetes
      mellitus with HbA1C.
PG  - 180-3
LID - 10.1136/medethics-2011-100086 [doi]
AB  - Since the 1990s, glycated haemoglobin (HbA1C) has been the gold standard for
      monitoring glycaemic control in people diagnosed as having either type 1 diabetes
      mellitus (T1DM) or type 2 diabetes mellitus (T2DM). Discussions are underway
      about diagnosing diabetes mellitus on the basis of HbA1C titres and using HbA1C
      tests to screen for T2DM. These discussions have focused on the relative benefits
      for individual patients, with some attention directed towards reduced costs to
      healthcare systems and benefits to society. We argue that there are strong
      ethical reasons for adopting HbA1C-based diagnosis and T2DM screening that have
      not yet been articulated. The rationale includes the differential impact of
      HbA1C-based diabetic testing on disadvantaged groups, and what we are beginning
      to learn about HbA1C vis-a-vis population health. Although it is arguable that
      screening must primarily benefit the individual, using HbA1C to diagnose and
      screen for T2DM may promote a more just distribution of health resources and lead
      to advances in investigating, monitoring and tackling the social determinants of 
      health.
FAU - Degeling, Chris
AU  - Degeling C
AD  - Population Health Intervention Research Centre, Calgary Institute of Population
      and Public Health, University of Calgary, 3280 Hospital Drive, Calgary, Alberta, 
      Canada. cjdegeli@ucalgary.ca
FAU - Rock, Melanie
AU  - Rock M
FAU - Rogers, Wendy A
AU  - Rogers WA
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111004
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
RN  - 0 (Glycated Hemoglobin A)
SB  - IM
MH  - Diabetes Mellitus, Type 1/*diagnosis/metabolism
MH  - Diabetes Mellitus, Type 2/*diagnosis/metabolism
MH  - Glycated Hemoglobin A/*analysis
MH  - Humans
MH  - Mass Screening/*ethics
MH  - Socioeconomic Factors
MH  - Vulnerable Populations
EDAT- 2011/10/06 06:00
MHDA- 2012/05/25 06:00
CRDT- 2011/10/06 06:00
PHST- 2011/10/06 06:00 [entrez]
PHST- 2011/10/06 06:00 [pubmed]
PHST- 2012/05/25 06:00 [medline]
AID - medethics-2011-100086 [pii]
AID - 10.1136/medethics-2011-100086 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Mar;38(3):180-3. doi: 10.1136/medethics-2011-100086. Epub 2011
      Oct 4.


PMID- 21971950
OWN - NLM
STAT- MEDLINE
DCOM- 20120330
LR  - 20120614
IS  - 1099-0798 (Electronic)
IS  - 0735-3936 (Linking)
VI  - 29
IP  - 6
DP  - 2011 Nov-Dec
TI  - Methodological, ethical, and legal considerations in drug court research.
PG  - 806-20
LID - 10.1002/bsl.1011 [doi]
AB  - Since their inception in the late 1980s, drug courts have become the most
      prevalent specialty court in the United States. A large body of outcome research 
      conducted over the past two decades has demonstrated that drug courts effectively
      reduce drug use and criminal recidivism, which has led to the rapid proliferation
      of these courts. Importantly, drug court research has flourished despite the many
      challenges faced by researchers when working with a vulnerable population of
      justice-involved substance users. In this article, we highlight the most common
      methodological, ethical, and legal challenges encountered in drug court research,
      and discuss ways in which researchers can overcome these challenges to conduct
      high-quality research. Drug court research exemplifies how rigorous empirical
      investigation can be accomplished in the criminal justice system, and it can
      serve as a useful model for researchers working in other parts of the judicial
      system.
CI  - 2011 John Wiley & Sons, Ltd.
FAU - DeMatteo, David
AU  - DeMatteo D
AD  - Drexel University, Department of Psychology, MS 626, 245 N. 15th St,
      Philadelphia, PA, USA. david.dematteo@drexel.edu
FAU - Filone, Sarah
AU  - Filone S
FAU - Laduke, Casey
AU  - Laduke C
LA  - eng
PT  - Journal Article
DEP - 20111004
PL  - United States
TA  - Behav Sci Law
JT  - Behavioral sciences & the law
JID - 8404861
SB  - IM
MH  - *Criminal Law
MH  - *Ethics, Research
MH  - Female
MH  - Humans
MH  - *Judicial Role
MH  - Male
MH  - Prisoners/*legislation & jurisprudence
MH  - *Research Design
MH  - Substance-Related Disorders/*rehabilitation
MH  - United States
EDAT- 2011/10/06 06:00
MHDA- 2012/03/31 06:00
CRDT- 2011/10/06 06:00
PHST- 2011/05/02 00:00 [received]
PHST- 2011/06/10 00:00 [revised]
PHST- 2011/06/14 00:00 [accepted]
PHST- 2011/10/06 06:00 [entrez]
PHST- 2011/10/06 06:00 [pubmed]
PHST- 2012/03/31 06:00 [medline]
AID - 10.1002/bsl.1011 [doi]
PST - ppublish
SO  - Behav Sci Law. 2011 Nov-Dec;29(6):806-20. doi: 10.1002/bsl.1011. Epub 2011 Oct 4.


PMID- 21971602
OWN - NLM
STAT- MEDLINE
DCOM- 20121016
LR  - 20211020
IS  - 1525-1497 (Electronic)
IS  - 0884-8734 (Linking)
VI  - 27
IP  - 2
DP  - 2012 Feb
TI  - Evidence, values, guidelines and rational decision-making.
PG  - 238-40
LID - 10.1007/s11606-011-1903-6 [doi]
AB  - Medical decision-making involves choices, which can lead to benefits or to harms.
      Most benefits and harms may or may not occur, and can be minor or major when they
      do. Medical research, especially randomized controlled trials, provides estimates
      of chance of occurrence and magnitude of event. Because there is no universally
      accepted method for weighing harms against benefits, and because the ethical
      principle of autonomy mandates informed choice by patient, medical
      decision-making is inherently an individualized process. It follows that the
      practice of aiming for universal implementation of standardized guidelines is
      irrational and unethical. Irrational because the possibility of benefits is
      implicitly valued more than the possibility of comparable harms, and unethical
      because guidelines remove decision making from the patient and give it instead to
      a physician, committee or health care system. This essay considers the cases of
      cancer screening and diabetes management, where guidelines often advocate
      universal implementation, without regard to informed choice and individual
      decision-making.
FAU - Barrett, Bruce
AU  - Barrett B
AD  - Department of Family Medicine, University of Wisconsin, 1100 Delaplaine Ct.,
      Madison, WI, USA. bruce.barrett@fammed.wisc.edu
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20111005
PL  - United States
TA  - J Gen Intern Med
JT  - Journal of general internal medicine
JID - 8605834
SB  - IM
MH  - *Decision Making
MH  - Evidence-Based Medicine/methods/*standards
MH  - Humans
MH  - Practice Guidelines as Topic/*standards
MH  - Randomized Controlled Trials as Topic/methods/standards
MH  - Reference Values
PMC - PMC3270230
EDAT- 2011/10/06 06:00
MHDA- 2012/10/17 06:00
CRDT- 2011/10/06 06:00
PHST- 2011/06/03 00:00 [received]
PHST- 2011/09/16 00:00 [accepted]
PHST- 2011/09/15 00:00 [revised]
PHST- 2011/10/06 06:00 [entrez]
PHST- 2011/10/06 06:00 [pubmed]
PHST- 2012/10/17 06:00 [medline]
AID - 10.1007/s11606-011-1903-6 [doi]
PST - ppublish
SO  - J Gen Intern Med. 2012 Feb;27(2):238-40. doi: 10.1007/s11606-011-1903-6. Epub
      2011 Oct 5.


PMID- 21971249
OWN - NLM
STAT- MEDLINE
DCOM- 20111216
LR  - 20111005
IS  - 0485-1439 (Print)
IS  - 0485-1439 (Linking)
VI  - 52
IP  - 10
DP  - 2011 Oct
TI  - [Science and ethics in clinical research].
PG  - 1702-4
FAU - Fukuda, Haruhiko
AU  - Fukuda H
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Rinsho Ketsueki
JT  - [Rinsho ketsueki] The Japanese journal of clinical hematology
JID - 2984782R
SB  - IM
MH  - Clinical Trials as Topic/*standards
MH  - *Ethics, Research
MH  - Reproducibility of Results
MH  - Research Design
EDAT- 2011/10/06 06:00
MHDA- 2011/12/17 06:00
CRDT- 2011/10/06 06:00
PHST- 2011/10/06 06:00 [entrez]
PHST- 2011/10/06 06:00 [pubmed]
PHST- 2011/12/17 06:00 [medline]
AID - JST.JSTAGE/rinketsu/52.1702 [pii]
PST - ppublish
SO  - Rinsho Ketsueki. 2011 Oct;52(10):1702-4.


PMID- 21970509
OWN - NLM
STAT- MEDLINE
DCOM- 20120111
LR  - 20211020
IS  - 1755-8794 (Electronic)
IS  - 1755-8794 (Linking)
VI  - 4
DP  - 2011 Oct 4
TI  - Bridging consent: from toll bridges to lift bridges?
PG  - 69
LID - 10.1186/1755-8794-4-69 [doi]
AB  - BACKGROUND: The ability to share human biological samples, associated data and
      results across disease-specific and population-based human research biobanks is
      becoming increasingly important for research into disease development and
      translation. Although informed consent often does not anticipate such
      cross-domain sharing, it is important to examine its plausibility. The purpose of
      this study was to explore the feasibility of bridging consent between
      disease-specific and population-based research. Comparative analyses of 1)
      current ethical and legal frameworks governing consent and 2) informed consent
      models found in disease-specific and population-based research were conducted.
      DISCUSSION: Ethical and legal frameworks governing consent dissuade cross-domain 
      data sharing. Paradoxically, analysis of consent models for disease-specific and 
      population-based research reveals such a high degree of similarity that bridging 
      consent could be possible if additional information regarding bridging was
      incorporated into consent forms. We submit that bridging of consent could be
      supported if current trends endorsing a new interpretation of consent are
      adopted. To illustrate this we sketch potential bridging consent scenarios.
      SUMMARY: A bridging consent, respectful of the spirit of initial consent, is
      feasible and would require only small changes to the content of consents
      currently being used. Under a bridging consent approach, the initial data and
      samples collection can serve an identified research project as well as contribute
      to the creation of a resource for a range of other projects.
FAU - Budin-Ljosne, Isabelle
AU  - Budin-Ljosne I
AD  - Norwegian Institute of Public Health, Division of Epidemiology, Department of
      Genes and Environment, PO Box 4404 Nydalen, NO-0403 Oslo, Norway.
      isabelle.budin.ljosne@fhi.no
FAU - Tasse, Anne Marie
AU  - Tasse AM
FAU - Knoppers, Bartha Maria
AU  - Knoppers BM
FAU - Harris, Jennifer R
AU  - Harris JR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111004
PL  - England
TA  - BMC Med Genomics
JT  - BMC medical genomics
JID - 101319628
SB  - IM
MH  - *Biological Specimen Banks/ethics/legislation & jurisprudence
MH  - Confidentiality/ethics/legislation & jurisprudence
MH  - Consent Forms/economics/ethics/legislation & jurisprudence
MH  - *Ethics, Research
MH  - Humans
MH  - Informed Consent/ethics/legislation & jurisprudence
MH  - *Research/legislation & jurisprudence
PMC - PMC3206837
EDAT- 2011/10/06 06:00
MHDA- 2012/01/12 06:00
CRDT- 2011/10/06 06:00
PHST- 2011/05/24 00:00 [received]
PHST- 2011/10/04 00:00 [accepted]
PHST- 2011/10/06 06:00 [entrez]
PHST- 2011/10/06 06:00 [pubmed]
PHST- 2012/01/12 06:00 [medline]
AID - 1755-8794-4-69 [pii]
AID - 10.1186/1755-8794-4-69 [doi]
PST - epublish
SO  - BMC Med Genomics. 2011 Oct 4;4:69. doi: 10.1186/1755-8794-4-69.


PMID- 21970478
OWN - NLM
STAT- MEDLINE
DCOM- 20111121
LR  - 20130116
IS  - 1543-2165 (Electronic)
IS  - 0003-9985 (Linking)
VI  - 135
IP  - 10
DP  - 2011 Oct
TI  - "No pay, no play": the end of professional ethics in pathology?
PG  - 1246
LID - 10.5858/arpa.2011-0288-ED [doi]
FAU - Hernandez, James S
AU  - Hernandez JS
LA  - eng
PT  - Editorial
PL  - United States
TA  - Arch Pathol Lab Med
JT  - Archives of pathology & laboratory medicine
JID - 7607091
SB  - IM
CIN - Eur Urol. 2012 Feb;61(2):424-5. PMID: 22186346
CIN - Arch Pathol Lab Med. 2012 Apr;136(4):354-5. PMID: 22458896
CIN - Arch Pathol Lab Med. 2012 Dec;136(12):1474-5; author reply 1475. PMID: 23194036
MH  - Humans
MH  - Pathology, Clinical/education/*ethics
MH  - Patient Satisfaction
MH  - Physician-Patient Relations/ethics
MH  - Societies, Medical
MH  - United States
EDAT- 2011/10/06 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/10/06 06:00
PHST- 2011/10/06 06:00 [entrez]
PHST- 2011/10/06 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.5858/arpa.2011-0288-ED [doi]
PST - ppublish
SO  - Arch Pathol Lab Med. 2011 Oct;135(10):1246. doi: 10.5858/arpa.2011-0288-ED.


PMID- 21970399
OWN - NLM
STAT- MEDLINE
DCOM- 20120301
LR  - 20211020
IS  - 1532-429X (Electronic)
IS  - 1097-6647 (Linking)
VI  - 13
DP  - 2011 Oct 4
TI  - Quantification and visualization of cardiovascular 4D velocity mapping
      accelerated with parallel imaging or k-t BLAST: head to head comparison and
      validation at 1.5 T and 3 T.
PG  - 55
LID - 10.1186/1532-429X-13-55 [doi]
AB  - BACKGROUND: Three-dimensional time-resolved (4D) phase-contrast (PC) CMR can
      visualize and quantify cardiovascular flow but is hampered by long acquisition
      times. Acceleration with SENSE or k-t BLAST are two possibilities but results on 
      validation are lacking, especially at 3 T. The aim of this study was therefore to
      validate quantitative in vivo cardiac 4D-acquisitions accelerated with parallel
      imaging and k-t BLAST at 1.5 T and 3 T with 2D-flow as the reference and to
      investigate if field strengths and type of acceleration have major effects on
      intracardiac flow visualization. METHODS: The local ethical committee approved
      the study. 13 healthy volunteers were scanned at both 1.5 T and 3 T in random
      order with 2D-flow of the aorta and main pulmonary artery and two 4D-flow
      sequences of the heart accelerated with SENSE and k-t BLAST respectively.
      2D-image planes were reconstructed at the aortic and pulmonary outflow. Flow
      curves were calculated and peak flows and stroke volumes (SV) compared to the
      results from 2D-flow acquisitions. Intra-cardiac flow was visualized using
      particle tracing and image quality based on the flow patterns of the particles
      was graded using a four-point scale. RESULTS: Good accuracy of SV quantification 
      was found using 3 T 4D-SENSE (r2 = 0.86, -0.7 +/- 7.6%) and although a larger
      bias was found on 1.5 T (r2 = 0.71, -3.6 +/- 14.8%), the difference was not
      significant (p = 0.46). Accuracy of 4D k-t BLAST for SV was lower (p < 0.01) on
      1.5 T (r2 = 0.65, -15.6 +/- 13.7%) compared to 3 T (r2 = 0.64, -4.6 +/- 10.0%).
      Peak flow was lower with 4D-SENSE at both 3 T and 1.5 T compared to 2D-flow (p < 
      0.01) and even lower with 4D k-t BLAST at both scanners (p < 0.01). Intracardiac 
      flow visualization did not differ between 1.5 T and 3 T (p = 0.09) or between
      4D-SENSE or 4D k-t BLAST (p = 0.85). CONCLUSIONS: The present study showed that
      quantitative 4D flow accelerated with SENSE has good accuracy at 3 T and compares
      favourably to 1.5 T. 4D flow accelerated with k-t BLAST underestimate flow
      velocities and thereby yield too high bias for intra-cardiac quantitative in vivo
      use at the present time. For intra-cardiac 4D-flow visualization, however, 1.5 T 
      and 3 T as well as SENSE or k-t BLAST can be used with similar quality.
FAU - Carlsson, Marcus
AU  - Carlsson M
AD  - Dept of Clinical Physiology, Lund University, Lund, Sweden.
      marcus.carlsson@med.lu.se
FAU - Toger, Johannes
AU  - Toger J
FAU - Kanski, Mikael
AU  - Kanski M
FAU - Bloch, Karin Markenroth
AU  - Bloch KM
FAU - Stahlberg, Freddy
AU  - Stahlberg F
FAU - Heiberg, Einar
AU  - Heiberg E
FAU - Arheden, Hakan
AU  - Arheden H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20111004
PL  - England
TA  - J Cardiovasc Magn Reson
JT  - Journal of cardiovascular magnetic resonance : official journal of the Society
      for Cardiovascular Magnetic Resonance
JID - 9815616
SB  - IM
MH  - Adult
MH  - Aorta/physiology
MH  - Blood Flow Velocity
MH  - *Coronary Circulation
MH  - Female
MH  - Humans
MH  - *Imaging, Three-Dimensional
MH  - Linear Models
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Myocardial Perfusion Imaging/*methods
MH  - Predictive Value of Tests
MH  - Pulmonary Circulation
MH  - Reference Values
MH  - Regional Blood Flow
MH  - Reproducibility of Results
MH  - Stroke Volume
MH  - Sweden
MH  - Time Factors
MH  - Young Adult
PMC - PMC3213199
EDAT- 2011/10/06 06:00
MHDA- 2012/03/02 06:00
CRDT- 2011/10/06 06:00
PHST- 2011/04/07 00:00 [received]
PHST- 2011/10/04 00:00 [accepted]
PHST- 2011/10/06 06:00 [entrez]
PHST- 2011/10/06 06:00 [pubmed]
PHST- 2012/03/02 06:00 [medline]
AID - 1532-429X-13-55 [pii]
AID - 10.1186/1532-429X-13-55 [doi]
PST - epublish
SO  - J Cardiovasc Magn Reson. 2011 Oct 4;13:55. doi: 10.1186/1532-429X-13-55.


PMID- 21970217
OWN - NLM
STAT- MEDLINE
DCOM- 20111118
LR  - 20211020
IS  - 1115-2613 (Print)
IS  - 1115-2613 (Linking)
VI  - 20
IP  - 3
DP  - 2011 Jul-Sep
TI  - Factors associated with decreased survival from neonatal malaria infection in
      Jos, North Central Nigeria.
PG  - 349-54
AB  - BACKGROUND: Malaria is a serious cause of morbidity and mortality in the neonatal
      period and account for a significant number of fetal wastage. Its diagnosis is
      difficult because of the overlap in clinical presentation with other infectious
      disease in the neonatal period. This study set out to examine the factors that
      are associated with an increased risk of mortality in neonates admitted with
      malaria. METHOD: Forty one neonates presenting between January and June 2009 were
      enrolled after obtaining ethical approval and informed consent from the mothers. 
      Information collected include gestational age, age at presentation, birth weight,
      clinical symptoms, associated medical conditions and pertinent pregnancy history.
      RESULTS: Of the 41 neonates studied, 24 (58.5%) were females, 29 (70.5%) were
      term neonates and 12 (29.3%) had low birth weight. Overall mortality was 24.4%,
      more male neonates (70%) had malaria compared to females (50.0%) and neonatal
      malaria was associated with a longer hospital stay (p < 0.001). Female neonates
      (RR = 0.81, CI = 0.69 0.95), neonatal malaria (RR = 0.63, CI = 0.54 0.73) and
      maternal negative HIV status (RR = 0.22, CI = 0.15 0.32) was associated with
      lower risk of mortality. Whereas, multiple symptoms at presentation (RR = 1.67,
      CI = 1.42 1.96), multiple medical conditions (RR = 1.59, CI = 1.37 1.84) and
      maternal malaria in pregnancy (RR = 1.54, CI = 1.23 1.29) were associated with
      increased risk of mortality. Maternal IPT use, gestational age and birth weight
      did not have any statistically significant relationship with mortality.
      CONCLUSION: Neonatal malaria is a significant cause of neonatal mortality; the
      risk of which is higher with the presence of other co-morbid factors. We suggest 
      a review of the IPT program and the introduction of maternal malaria screening at
      time of delivery.
FAU - Yilgwan, Christopher S
AU  - Yilgwan CS
AD  - Department of Paediatrics University of Jos/Jos University Teaching Hospital, Jos
      Nigeria. yilgwan@yahoo.com
FAU - Hyacinth, Hyacinth I
AU  - Hyacinth HI
FAU - Oguche, Stephen
AU  - Oguche S
LA  - eng
GR  - R01 HL138423/HL/NHLBI NIH HHS/United States
GR  - R21 HL092358/HL/NHLBI NIH HHS/United States
GR  - R21HL092358/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - Nigeria
TA  - Niger J Med
JT  - Nigerian journal of medicine : journal of the National Association of Resident
      Doctors of Nigeria
JID - 100888321
SB  - IM
MH  - Adult
MH  - Birth Weight
MH  - Comorbidity
MH  - Female
MH  - Fever/etiology
MH  - Hospitals, University/statistics & numerical data
MH  - Humans
MH  - Incidence
MH  - *Infant Mortality
MH  - Infant, Newborn
MH  - Length of Stay
MH  - Malaria/blood/diagnosis/*mortality
MH  - Male
MH  - Nigeria/epidemiology
MH  - Parasitemia/diagnosis/*mortality
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/epidemiology/parasitology
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Survival Rate
PMC - PMC5592110
MID - NIHMS903112
EDAT- 2011/10/06 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/10/06 06:00
PHST- 2011/10/06 06:00 [entrez]
PHST- 2011/10/06 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PST - ppublish
SO  - Niger J Med. 2011 Jul-Sep;20(3):349-54.


PMID- 21970211
OWN - NLM
STAT- MEDLINE
DCOM- 20111118
LR  - 20131121
IS  - 1115-2613 (Print)
IS  - 1115-2613 (Linking)
VI  - 20
IP  - 3
DP  - 2011 Jul-Sep
TI  - Study of serological and clinical factors among juvenile rheumatoid arthritis
      cases admitted to Mofid Children's Hospital and Imam Hossein Hospital, Tehran,
      Iran.
PG  - 322-6
AB  - INTRODUCTION AND AIM: Juvenile Rheumatoid Arthritis is the most common
      rheumatologic disease of childhood period. The aim of study was to compare ANA
      positive and ANA negative cases. PATIENTS AND METHODS: This observation study was
      performed as correlation research. All cases with diagnosis ofJRA who visited
      Mofid Children's Hospital and Imam Hossein Hospital were included in this study. 
      Duration of this study was from 2006, 1 October till 2008, 31 October. All
      patients were examined carefully by an experienced pediatric rheumatologist. Age,
      sex, disease onset, age at diagnosis, RF, ANA, HLA-B27, ESR, type of disease,
      disease activity, and duration of inactivity were included in this study. ANA
      titer was measured by immunoflurocence technique. Patients were categorized
      according to sex, ANA, and type of disease and then group was compared with each 
      other. Data was analyzed by SPSS Ver. 16 (Chicago, IL, USA). This study was
      approved by Ethical Committee of university. RESULTS: In this study, 61 cases
      were enrolled. Twenty five cases (41%) were males and 36 cases were females. Mean
      of age at disease onset was 6.1 +/- 3.1 (Range 6 months to 12.5 years). Mean of
      age at disease diagnosis was 6.7 +/- 3.2. Mean of age at time of study was 7.6
      +/- 3.5 (1.4 to 14 years). From all cases, 38 cases were oligoarticular, 18 cases
      were polyarticular and 5 cases were systemic onset. From 61 cases, 22 (36.1%)
      cases, had ANA positive JRA. Of these cases, 14 cases were oligoarticular and 8
      cases were polyarticular. CONCLUSION: Except for sex and morning stiffness, there
      is significant correlation between type of disease and ANA,RF,HLA-B27, response
      to treatment, early onset erosion, subcutaneous nodule, and uveitis (P < 0.05).
      There is significant correlation between sex and ANA, RF, HLA-B27, early erosion,
      response to treatment, subcutaneous treatment, and uveitis (P < 0.05). There is
      significant correlation between ANA seropositivity and HLA-B27, early erosion,
      response to treatment, uveitis and subcutaneous nodule. Our results showed that
      there is significant correlation among ANA and other factors except morning
      stiffness. Another prospective study is recommended.
FAU - Shiari, Reza
AU  - Shiari R
AD  - Mofid Children's Hospital, Shahid Beheshti University, M.C., Tehran, Iran.
FAU - Torabizadeh, Mehdi
AU  - Torabizadeh M
FAU - Javaherizadeh, Hazhir
AU  - Javaherizadeh H
LA  - eng
PT  - Journal Article
PL  - Nigeria
TA  - Niger J Med
JT  - Nigerian journal of medicine : journal of the National Association of Resident
      Doctors of Nigeria
JID - 100888321
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (HLA-B27 Antigen)
SB  - IM
MH  - Age Distribution
MH  - Antibodies, Antinuclear/blood/*immunology
MH  - Arthritis, Juvenile/classification/*diagnosis/immunology
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Fluorescent Antibody Technique
MH  - HLA-B27 Antigen/blood/*immunology
MH  - Hospitals, Pediatric
MH  - Humans
MH  - Infant
MH  - Iran
MH  - Male
MH  - Sex Distribution
EDAT- 2011/10/06 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/10/06 06:00
PHST- 2011/10/06 06:00 [entrez]
PHST- 2011/10/06 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PST - ppublish
SO  - Niger J Med. 2011 Jul-Sep;20(3):322-6.


PMID- 21970210
OWN - NLM
STAT- MEDLINE
DCOM- 20111118
LR  - 20111005
IS  - 1115-2613 (Print)
IS  - 1115-2613 (Linking)
VI  - 20
IP  - 3
DP  - 2011 Jul-Sep
TI  - The burden and management of infants with life-long and irreversible hearing
      impairment in Nigeria.
PG  - 310-21
AB  - If left untreated or treated late and inappropriately, sensorineural hearing
      impairment has several adverse, irreversible and life-long health, psycho-social 
      and economic consequences for the affected infants and their families. This
      seminar paper sets out to describe the burden, current practices and management
      options for sensorineural or permanent hearing impairment in early infancy for
      primary care physicians in Nigeria against the backdrop of their role as primary 
      or first contact for all health consultations. Available studies suggest that up 
      to 2.7% or 162,000 of the 6 million infants born annually may have permanent
      hearing impairment. The underlying aetiological factors may not be determined in 
      the majority of the infants thus limiting the effectiveness of any primary
      prevention initiatives. However, the affected infants can be detected accurately 
      with objective screening technologies such as otoacoustic emissions and auditory 
      brainstem response in hospital or community settings. The ethical and scientific 
      rationale for this intervention has been well established. Barring the challenge 
      of parental follow-up default which is not insurmountable, affected infants and
      their families can be supported to establish appropriate auditory-based
      communication, avoid potentially harmful traditional therapies and child neglect 
      commonly associated with childhood hearing impairment. Primary care providers in 
      private and public practice have a crucial role in guiding parents to seek timely
      and appropriate services from ear care providers and child development
      specialists to ensure optimal child growth and developmental outcomes. On-going
      parental commitment to and active participation in the selected intervention
      programmes are essential to satisfactory long-term outcomes.
FAU - Olusanya, Bolajoko O
AU  - Olusanya BO
AD  - Department of Community Health and Primary Care College of Medicine, University
      of Lagos, Lagos, Nigeria. boolusanya@aol.com
FAU - Bamigboye, Babatunde A
AU  - Bamigboye BA
FAU - Somefun, Abayomi O
AU  - Somefun AO
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Nigeria
TA  - Niger J Med
JT  - Nigerian journal of medicine : journal of the National Association of Resident
      Doctors of Nigeria
JID - 100888321
SB  - IM
MH  - Cost of Illness
MH  - Early Diagnosis
MH  - Hearing Loss/classification/*diagnosis/economics/rehabilitation
MH  - Hearing Tests/*methods
MH  - Humans
MH  - Infant, Newborn
MH  - Neonatal Screening/*methods
MH  - Nigeria
MH  - Parents
MH  - Risk Factors
EDAT- 2011/10/06 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/10/06 06:00
PHST- 2011/10/06 06:00 [entrez]
PHST- 2011/10/06 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PST - ppublish
SO  - Niger J Med. 2011 Jul-Sep;20(3):310-21.


PMID- 21968439
OWN - NLM
STAT- MEDLINE
DCOM- 20111222
LR  - 20220330
IS  - 1940-087X (Electronic)
IS  - 1940-087X (Linking)
IP  - 55
DP  - 2011 Sep 26
TI  - A simple guide screw method for intracranial xenograft studies in mice.
LID - 10.3791/3157 [doi]
LID - 3157 [pii]
AB  - The grafting of human tumor cells into the brain of immunosuppressed mice is an
      established method for the study of brain cancers including glioblastoma (glioma)
      and medulloblastoma. The widely used stereotactic approach only allows for the
      injection of a single animal at a time, is labor intensive and requires highly
      specialized equipment. The guide screw method, initially developed by Lal et
      al.,(1) was developed to eliminate cumbersome stereotactic procedures. We now
      describe a modified guide screw approach that is rapid and exceptionally safe;
      both of which are critical ethical considerations. Notably, our procedure now
      incorporates an infusion pump that allows up to 10 animals to be simultaneously
      injected with tumor cells. To demonstrate the utility of this procedure, we
      established human U87MG glioma cells as intracranial xenografts in mice, which
      were then treated with AMG102; a fully human antibody directed to HGF/scatter
      factor currently undergoing clinical evaluation(2-5). Systemic injection of
      AMG102 significantly prolonged the survival of all mice with intracranial U87MG
      xenografts and resulted in a number of complete cures. This study demonstrates
      that the guide screw method is an inexpensive, highly reproducible approach for
      establishing intracranial xenografts. Furthermore, it provides a relevant
      physiological model for validating novel therapeutic strategies for the treatment
      of brain cancers.
FAU - Donoghue, Jacqueline F
AU  - Donoghue JF
AD  - Monash Institute of Medical Research.
FAU - Bogler, Oliver
AU  - Bogler O
FAU - Johns, Terrance G
AU  - Johns TG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Video-Audio Media
DEP - 20110926
PL  - United States
TA  - J Vis Exp
JT  - Journal of visualized experiments : JoVE
JID - 101313252
SB  - IM
MH  - Animals
MH  - Brain Neoplasms/*pathology
MH  - Cell Line, Tumor
MH  - Glioma/*pathology
MH  - Humans
MH  - Mice
MH  - Neoplasm Transplantation/*methods
MH  - Neurosurgical Procedures/*instrumentation/methods
MH  - Skull/*surgery
MH  - Transplantation, Heterologous/*methods
MH  - Xenograft Model Antitumor Assays/methods
PMC - PMC3230180
EDAT- 2011/10/05 06:00
MHDA- 2011/12/23 06:00
CRDT- 2011/10/05 06:00
PHST- 2011/10/05 06:00 [entrez]
PHST- 2011/10/05 06:00 [pubmed]
PHST- 2011/12/23 06:00 [medline]
AID - 3157 [pii]
AID - 10.3791/3157 [doi]
PST - epublish
SO  - J Vis Exp. 2011 Sep 26;(55). pii: 3157. doi: 10.3791/3157.


PMID- 21968218
OWN - NLM
STAT- MEDLINE
DCOM- 20120925
LR  - 20120618
IS  - 1532-8449 (Electronic)
IS  - 0882-5963 (Linking)
VI  - 27
IP  - 4
DP  - 2012 Aug
TI  - Child with idiopathic pulmonary hemosiderosis: a case report from Pakistan with
      multiple ethical and moral issues.
PG  - e22-8
LID - 10.1016/j.pedn.2011.08.006 [doi]
AB  - This report discusses the case of a young Pakistani child diagnosed with
      idiopathic pulmonary hemosiderosis (IPH). The key features of IPH were iron
      deficiency anemia and pulmonary symptoms due to recurrent pulmonary hemorrhages. 
      The child showed complications of the disease process because of late diagnosis. 
      Because various ethical and moral issues were associated with the diagnosis and
      management of IPH, this case provides insights about the care burden of health
      care professionals and a child's parents in a Pakistani pediatric setting. During
      the course of the child's treatment at one of the private tertiary care settings 
      of Karachi, Pakistan, the key challenges were as follows: declaring the diagnosis
      to the parents, dealing with the request of the child's parents for withdrawal of
      ventilatory support and withholding treatment, deciding the code status of the
      child, and ensuring the quality of the child's life after discharge from the
      hospital. It was learned from this case report that shared decision making and
      open communication with the child's family enabled the pediatric health care
      professionals to determine what was in the best interest of the child, resulting 
      in provision of effective palliative care to the child. Moreover, it was realized
      that early detection of the disease and availability of hospice care can
      facilitate palliative care of children diagnosed with IPH.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Hirani, Shela Akbar Ali
AU  - Hirani SA
AD  - Aga Khan University School of Nursing, Karachi, Pakistan. shela.hirani@aku.edu
FAU - Rahman, Arshalooz
AU  - Rahman A
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20111007
PL  - United States
TA  - J Pediatr Nurs
JT  - Journal of pediatric nursing
JID - 8607529
RN  - Idiopathic pulmonary hemosiderosis
SB  - IM
MH  - Child
MH  - Delayed Diagnosis/ethics
MH  - Health Services Accessibility/economics/ethics
MH  - Hemosiderosis/*diagnosis/*therapy
MH  - Hospitals, Private/economics
MH  - Humans
MH  - Lung Diseases/*diagnosis/*therapy
MH  - Male
MH  - Pakistan
MH  - Palliative Care/*ethics
MH  - Professional-Family Relations
EDAT- 2011/10/05 06:00
MHDA- 2012/09/26 06:00
CRDT- 2011/10/05 06:00
PHST- 2010/12/19 00:00 [received]
PHST- 2011/08/12 00:00 [revised]
PHST- 2011/08/30 00:00 [accepted]
PHST- 2011/10/05 06:00 [entrez]
PHST- 2011/10/05 06:00 [pubmed]
PHST- 2012/09/26 06:00 [medline]
AID - S0882-5963(11)00587-2 [pii]
AID - 10.1016/j.pedn.2011.08.006 [doi]
PST - ppublish
SO  - J Pediatr Nurs. 2012 Aug;27(4):e22-8. doi: 10.1016/j.pedn.2011.08.006. Epub 2011 
      Oct 7.


PMID- 21967981
OWN - NLM
STAT- MEDLINE
DCOM- 20120207
LR  - 20211020
IS  - 1477-7819 (Electronic)
IS  - 1477-7819 (Linking)
VI  - 9
DP  - 2011 Oct 3
TI  - Case report: The management of advanced oral cancer in a Jehovah's Witness using 
      the Ultracision Harmonic Scalpel.
PG  - 115
LID - 10.1186/1477-7819-9-115 [doi]
AB  - We present the first case of a head and neck oncological procedure accomplished
      in a Jehovah's Witness using the Ultracision Harmonic Scalpel (Ethicon,
      Cincinnati, OH). Jehovah's Witnesses present a serious challenge to the head and 
      neck cancer surgeon due to their refusal to accept transfusion of any blood
      products. However, our experience reinforces the view that surgical management of
      head and neck cancer is possible in these patients. We show the Harmonic Scalpel,
      an ultrasonic tissue dissector, to be a useful surgical tool in obviating the
      need for blood transfusion. Preoperative optimisation, intra-operative surgical
      and anaesthetic techniques are also fully discussed.
FAU - Kullar, Peter J
AU  - Kullar PJ
AD  - Department of Maxillofacial Surgery Royal Victoria Hospital Newcastle-Upon-Tyne
      UK. peterkullar@hotmail.com
FAU - Sorenson, Kristian
AU  - Sorenson K
FAU - Weerakkody, Ruwan
AU  - Weerakkody R
FAU - Adams, James
AU  - Adams J
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20111003
PL  - England
TA  - World J Surg Oncol
JT  - World journal of surgical oncology
JID - 101170544
SB  - IM
MH  - Blood Loss, Surgical/*prevention & control
MH  - Blood Transfusion
MH  - Carcinoma, Squamous Cell/pathology/*surgery
MH  - Female
MH  - Humans
MH  - *Jehovah's Witnesses
MH  - Middle Aged
MH  - Mouth Neoplasms/pathology/*surgery
MH  - Preoperative Care
MH  - Surgical Flaps
MH  - *Surgical Instruments
MH  - Treatment Outcome
PMC - PMC3204256
EDAT- 2011/10/05 06:00
MHDA- 2012/02/09 06:00
CRDT- 2011/10/05 06:00
PHST- 2011/01/31 00:00 [received]
PHST- 2011/10/03 00:00 [accepted]
PHST- 2011/10/05 06:00 [entrez]
PHST- 2011/10/05 06:00 [pubmed]
PHST- 2012/02/09 06:00 [medline]
AID - 1477-7819-9-115 [pii]
AID - 10.1186/1477-7819-9-115 [doi]
PST - epublish
SO  - World J Surg Oncol. 2011 Oct 3;9:115. doi: 10.1186/1477-7819-9-115.


PMID- 21967951
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20220409
IS  - 1097-6752 (Electronic)
IS  - 0889-5406 (Linking)
VI  - 140
IP  - 4
DP  - 2011 Oct
TI  - Sample size estimation: an overview with applications to orthodontic clinical
      trial designs.
PG  - e141-6
LID - 10.1016/j.ajodo.2011.04.021 [doi]
AB  - Proper sample size estimation is an important part of clinical trial methodology 
      and closely related to the precision and power of the trial's results. Trials
      with sufficient sample sizes are scientifically and ethically justified and more 
      credible compared with trials with insufficient sizes. Planning clinical trials
      with inadequate sample sizes might be considered as a waste of time and
      resources, as well as unethical, since patients might be enrolled in a study in
      which the expected results will not be trusted and are unlikely to have an impact
      on clinical practice. Because of the low emphasis of sample size calculation in
      clinical trials in orthodontics, it is the objective of this article to introduce
      the orthodontic clinician to the importance and the general principles of sample 
      size calculations for randomized controlled trials to serve as guidance for study
      designs and as a tool for quality assessment when reviewing published clinical
      trials in our specialty. Examples of calculations are shown for 2-arm parallel
      trials applicable to orthodontics. The working examples are analyzed, and the
      implications of design or inherent complexities in each category are discussed.
CI  - Copyright (c) 2011 American Association of Orthodontists. Published by Mosby,
      Inc. All rights reserved.
FAU - Pandis, Nikolaos
AU  - Pandis N
AD  - Department of Orthodontics and Dentofacial Orthopedics, Dental School/Medical
      Faculty, University of Bern, Bern, Switzerland. npandis@yahoo.com
FAU - Polychronopoulou, Argy
AU  - Polychronopoulou A
FAU - Eliades, Theodore
AU  - Eliades T
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Am J Orthod Dentofacial Orthop
JT  - American journal of orthodontics and dentofacial orthopedics : official
      publication of the American Association of Orthodontists, its constituent
      societies, and the American Board of Orthodontics
JID - 8610224
SB  - IM
MH  - Clinical Trials as Topic/*statistics & numerical data
MH  - Humans
MH  - Nomograms
MH  - Orthodontics/statistics & numerical data
MH  - Randomized Controlled Trials as Topic/statistics & numerical data
MH  - Reproducibility of Results
MH  - Research Design/*statistics & numerical data
MH  - *Sample Size
MH  - Treatment Outcome
EDAT- 2011/10/05 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/10/05 06:00
PHST- 2010/09/01 00:00 [received]
PHST- 2011/04/01 00:00 [revised]
PHST- 2011/04/01 00:00 [accepted]
PHST- 2011/10/05 06:00 [entrez]
PHST- 2011/10/05 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0889-5406(11)00618-4 [pii]
AID - 10.1016/j.ajodo.2011.04.021 [doi]
PST - ppublish
SO  - Am J Orthod Dentofacial Orthop. 2011 Oct;140(4):e141-6. doi:
      10.1016/j.ajodo.2011.04.021.


PMID- 21967949
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20131121
IS  - 1097-6752 (Electronic)
IS  - 0889-5406 (Linking)
VI  - 140
IP  - 4
DP  - 2011 Oct
TI  - Litigation, legislation & ethics. Can you hear me now?
PG  - 592-4
LID - 10.1016/j.ajodo.2011.06.015 [doi]
FAU - Jerrold, Laurance
AU  - Jerrold L
AD  - Orthodontic Consulting Group, LLC, Jacksonville, Fla., USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Orthod Dentofacial Orthop
JT  - American journal of orthodontics and dentofacial orthopedics : official
      publication of the American Association of Orthodontists, its constituent
      societies, and the American Board of Orthodontics
JID - 8610224
SB  - IM
MH  - Communication
MH  - Communication Aids for Disabled
MH  - *Deafness
MH  - Dental Care for Disabled/economics/*ethics/legislation & jurisprudence
MH  - Dentist-Patient Relations/*ethics
MH  - Health Services Accessibility/legislation & jurisprudence
MH  - Humans
MH  - Persons With Hearing Impairments
MH  - Practice Management, Dental/economics
MH  - *Sign Language
MH  - Taxes/economics
EDAT- 2011/10/05 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/10/05 06:00
PHST- 2011/06/01 00:00 [received]
PHST- 2011/06/01 00:00 [revised]
PHST- 2011/06/01 00:00 [accepted]
PHST- 2011/10/05 06:00 [entrez]
PHST- 2011/10/05 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0889-5406(11)00609-3 [pii]
AID - 10.1016/j.ajodo.2011.06.015 [doi]
PST - ppublish
SO  - Am J Orthod Dentofacial Orthop. 2011 Oct;140(4):592-4. doi:
      10.1016/j.ajodo.2011.06.015.


PMID- 21967800
OWN - NLM
STAT- MEDLINE
DCOM- 20120202
LR  - 20211020
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 12
DP  - 2011 Oct 4
TI  - Effectiveness evaluation of an integrated automatic thermomechanic massage system
      (SMATH(R) system) in non-specific sub-acute and chronic low back pain - a
      randomized double-blinded controlled trial, comparing SMATH therapy versus sham
      therapy: study protocol for a randomized controlled trial.
PG  - 216
LID - 10.1186/1745-6215-12-216 [doi]
AB  - BACKGROUND: Low back pain (LBP) is a major health problem in modern society, with
      70-85% of the population experiencing LBP at some time in their lives. Each year,
      5-10% of the workforce misses work due to LBP, most for less than 7 days. Almost 
      10% of all patients are at risk of developing chronic pain and disability. Little
      clinical evidence is available for the majority of treatments used in LBP
      therapy. However, moderate evidence exists for interdisciplinary rehabilitation, 
      exercise, acupuncture, spinal manipulation, and cognitive behavioral therapy for 
      subacute and chronic LBP. The SMATH(R) system (system for automatic
      thermomechanic massage in health) is a new medical device (MD) that combines
      basic principles of mechanical massage, thermotherapy, acupressure, infrared
      therapy, and moxibustion. SMATH(R) is suitable for automatic multidisciplinary
      treatment on patients with non-specific sub-acute and chronic LBP.
      METHODS/DESIGN: This paper describes the protocol for a double-blinded,
      sham-controlled, randomized, single-center short term clinical trial in patients 
      with non-specific sub-acute and chronic LBP aged 18 to 70 years. The primary
      outcome will be the effectiveness of SMATH(R) versus sham therapy (medical device
      without active principles) determined by evaluating self perceived physical
      function with Roland Morris Disability Questionnaire (RMDQ) scores after 4 weeks 
      of treatment (end of treatment). Major secondary outcome will be effectiveness of
      SMATH(R) determined by evaluating self perceived physical function comparing RMDQ
      scores between end of treatment and baseline. The trial part of the study will
      take 7 months while observational follow-up will take 11 months. The sample size 
      will be 72 participants (36 for each arm). The project has been approved by the
      Ethical Committee of Cremona Hospital, Italy on 29 November 2010. DISCUSSION:
      Compared to other medical specialties, physical and rehabilitation medicine (PRM)
      has not yet received the deserved recognition from clinicians and researchers in 
      the scientific community, especially for medical devices. The best way to change 
      this disadvantage is through well-conducted clinical research in sham-controlled 
      randomized trials. Sham treatment groups are essential for improving the level of
      evidence-based practice in PRM. The present trial will counter the general lack
      of evidence concerning medical devices used in LBP therapy. TRIAL REGISTRATION:
      ISRCTN: ISRCTN08714168.
FAU - Buselli, Paolo
AU  - Buselli P
AD  - Hospital Istituti Ospitalieri di Cremona, Physical and Rehabilitation Medicine
      Department, Cremona, Italy. buselli.paolo@gmail.com
FAU - Bosoni, Roberto
AU  - Bosoni R
FAU - Buse, Gabriella
AU  - Buse G
FAU - Fasoli, Paola
AU  - Fasoli P
FAU - La Scala, Elide
AU  - La Scala E
FAU - Mazzolari, Rita
AU  - Mazzolari R
FAU - Zanetti, Federica
AU  - Zanetti F
FAU - Messina, Sara
AU  - Messina S
LA  - eng
SI  - ISRCTN/ISRCTN08714168
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20111004
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
SB  - IM
MH  - Acupressure
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Chronic Disease
MH  - *Clinical Protocols
MH  - Double-Blind Method
MH  - Humans
MH  - Hyperthermia, Induced
MH  - Infrared Rays/therapeutic use
MH  - Low Back Pain/*therapy
MH  - Massage/*instrumentation/methods
MH  - Middle Aged
MH  - Moxibustion
MH  - Outcome Assessment, Health Care
MH  - Research Design
MH  - Sample Size
PMC - PMC3214170
EDAT- 2011/10/05 06:00
MHDA- 2012/02/03 06:00
CRDT- 2011/10/05 06:00
PHST- 2011/03/18 00:00 [received]
PHST- 2011/10/04 00:00 [accepted]
PHST- 2011/10/05 06:00 [entrez]
PHST- 2011/10/05 06:00 [pubmed]
PHST- 2012/02/03 06:00 [medline]
AID - 1745-6215-12-216 [pii]
AID - 10.1186/1745-6215-12-216 [doi]
PST - epublish
SO  - Trials. 2011 Oct 4;12:216. doi: 10.1186/1745-6215-12-216.


PMID- 21967753
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 2045-709X (Electronic)
IS  - 2045-709X (Linking)
VI  - 19
DP  - 2011 Oct 3
TI  - Retraction: a descriptive study of a manual therapy intervention within a
      randomised controlled trial for hamstring and lower limb injury prevention.
PG  - 24
LID - 10.1186/2045-709X-19-24 [doi]
AB  - The journal has been informed by its publisher BioMed Central that contrary to
      the statement in this article [Wayne Hoskins, Henry Pollard, Chiropractic &
      Osteopathy 2010, 18:23], they have been advised by the authors' institution
      Macquarie University, that its Human Research Ethics Committee did not approve
      this study. Because the study was conducted without institutional ethics
      committee approval it has been retracted.
FAU - Hoskins, Wayne
AU  - Hoskins W
AD  - Department of Chiropractic, Faculty of Science, Macquarie University, NSW 2109,
      Australia. waynehoskins@iinet.net.au.
FAU - Pollard, Henry
AU  - Pollard H
LA  - eng
PT  - Journal Article
PT  - Retraction of Publication
DEP - 20111003
PL  - England
TA  - Chiropr Man Therap
JT  - Chiropractic & manual therapies
JID - 101551481
ROF - Chiropr Osteopat. 2010 Aug 09;18:23. PMID: 20696040
PMC - PMC3204266
EDAT- 2011/10/05 06:00
MHDA- 2011/10/05 06:01
CRDT- 2011/10/05 06:00
PHST- 2011/09/05 00:00 [received]
PHST- 2011/10/03 00:00 [accepted]
PHST- 2011/10/05 06:00 [entrez]
PHST- 2011/10/05 06:00 [pubmed]
PHST- 2011/10/05 06:01 [medline]
AID - 2045-709X-19-24 [pii]
AID - 10.1186/2045-709X-19-24 [doi]
PST - epublish
SO  - Chiropr Man Therap. 2011 Oct 3;19:24. doi: 10.1186/2045-709X-19-24.


PMID- 21967468
OWN - NLM
STAT- MEDLINE
DCOM- 20120601
LR  - 20160511
IS  - 1945-0257 (Electronic)
IS  - 1945-0257 (Linking)
VI  - 16
IP  - 1
DP  - 2012 Jan
TI  - Determination of hepatitis C virus genotypes in pruritus patients in saudi
      arabia.
PG  - 46-9
LID - 10.1089/gtmb.2011.0064 [doi]
AB  - The main objective of this study was to estimate the prevalence of Hepatitis C
      virus (HCV) genotypes in 56 pruritus patients and 50 healthy blood donors on the 
      basis of clinical and laboratory investigations. Both demographic and clinical
      data were collected from each subject after obtaining informed consent and
      approval from an ethics committee. Ten milliliters of venous blood was collected 
      from fasting patients (8-10 h) and serum was used for aspartate transaminase and 
      alanine transaminase tests, anti-HCV antibody testing, HCV-RNA polymerase chain
      reaction screening, and genotyping analysis. HCV was found to be significantly
      predominant over HBV infection among the pruritus patients (p<0.001). Twelve
      pruritus patients (21.42%) were positive for anti-HCV antibodies and nine of them
      were confirmed positive for HCV RNA presence. Of the two major genotypes
      revealed, genotype 4 was found to be significantly predominant over the mixed
      genotype, that is, 4a/c+3a (p<0.001). Subtyping results showed that a significant
      majority of the type 4 were of the HCV subtype 4a (five patients), followed by 4c
      (two patients) and 4b genotypes (one patient) and mixed genotype 4a/c+3a (one
      patient). Results of this prospective study indicated the significant association
      between pruritus and HCV infection. HCV genotype 4 is the most predominant
      genotype among the pruritus patients and warrants larger studies in different
      ethnicities to find the molecular association between HCV genetic variants and
      pruritus.
FAU - Halawani, Mona
AU  - Halawani M
AD  - Department of Dermatology, College of Medicine and King Khalid University
      Hospital, King Saud University , Riyadh, Kingdom of Saudi Arabia.
FAU - Bakir, Talal M
AU  - Bakir TM
LA  - eng
PT  - Journal Article
DEP - 20111003
PL  - United States
TA  - Genet Test Mol Biomarkers
JT  - Genetic testing and molecular biomarkers
JID - 101494210
RN  - 0 (Hepatitis C Antibodies)
RN  - 0 (RNA, Viral)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Female
MH  - Genotype
MH  - Hepacivirus/*genetics/isolation & purification
MH  - Hepatitis C/complications/diagnosis/epidemiology/virology
MH  - Hepatitis C Antibodies/analysis/blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Molecular Typing/*methods
MH  - Pruritus/blood/complications/epidemiology/*virology
MH  - RNA, Viral/analysis/genetics
MH  - Saudi Arabia/epidemiology
MH  - Seroepidemiologic Studies
MH  - Young Adult
EDAT- 2011/10/05 06:00
MHDA- 2012/06/02 06:00
CRDT- 2011/10/05 06:00
PHST- 2011/10/05 06:00 [entrez]
PHST- 2011/10/05 06:00 [pubmed]
PHST- 2012/06/02 06:00 [medline]
AID - 10.1089/gtmb.2011.0064 [doi]
PST - ppublish
SO  - Genet Test Mol Biomarkers. 2012 Jan;16(1):46-9. doi: 10.1089/gtmb.2011.0064. Epub
      2011 Oct 3.


PMID- 21967209
OWN - NLM
STAT- MEDLINE
DCOM- 20120127
LR  - 20181201
IS  - 1935-990X (Electronic)
IS  - 0003-066X (Linking)
VI  - 66
IP  - 7
DP  - 2011 Oct
TI  - The dark side of comprehensive soldier fitness.
PG  - 643-4; discussion 646-7
LID - 10.1037/a0025272 [doi]
AB  - Comprehensive Soldier Fitness (CSF), the focus of the January 2011 special issue 
      of the American Psychologist, is a $125 million resilience training initiative
      designed to reduce and prevent the adverse psychological consequences of combat
      for soldiers and veterans. These are worthy goals. Soldiers and veterans deserve 
      the best care possible, and military psychologists have critically important
      roles to play. But the special issue is troubling in several important respects. 
      Elsewhere, we have offered a detailed review (Eidelson, Pilisuk, & Soldz, 2011). 
      Here we offer only a summary of our concerns. The CSF program is a massive
      research project launched without pilot testing to determine, first, the
      effectiveness of the training in a military environment. This is highly irregular
      and obviously worrisome considering the stakes. No evidence was provided
      indicating that CSF received preliminary review by an independent ethics review
      board. There are other ethically fraught possibilities.This special issue reveals
      much about current moral challenges facing the profession of psychology.
FAU - Eidelson, Roy
AU  - Eidelson R
AD  - Eidelson Consulting and Bryn Mawr College, USA. reidelson@eidelsonconsulting.com
FAU - Pilisuk, Marc
AU  - Pilisuk M
FAU - Soldz, Stephen
AU  - Soldz S
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am Psychol
JT  - The American psychologist
JID - 0370521
SB  - IM
CON - Am Psychol. 2011 Jan;66(1):82-6. PMID: 21219053
MH  - Humans
MH  - Military Personnel/*psychology
MH  - Psychology/*trends
EDAT- 2011/10/05 06:00
MHDA- 2012/01/28 06:00
CRDT- 2011/10/05 06:00
PHST- 2011/10/05 06:00 [entrez]
PHST- 2011/10/05 06:00 [pubmed]
PHST- 2012/01/28 06:00 [medline]
AID - 2011-22112-010 [pii]
AID - 10.1037/a0025272 [doi]
PST - ppublish
SO  - Am Psychol. 2011 Oct;66(7):643-4; discussion 646-7. doi: 10.1037/a0025272.


PMID- 21966989
OWN - NLM
STAT- MEDLINE
DCOM- 20120305
LR  - 20111104
IS  - 1557-7740 (Electronic)
IS  - 1557-7740 (Linking)
VI  - 14
IP  - 11
DP  - 2011 Nov
TI  - End-of-life decisions: a comparative survey on (teaching) experiences, views, and
      ethico-legal knowledge of final-year medical students in Germany and France.
PG  - 1206-10
LID - 10.1089/jpm.2011.0184 [doi]
AB  - BACKGROUND: Research on the teaching experiences and knowledge of medical
      students on end-of-life decisions in medicine is important because it provides
      information on the competency of future doctors with respect to an important
      field of clinical practice and can support the development of a curriculum.
      METHOD: A multiple-choice and free-text survey on the teaching experiences and
      knowledge of final-year medical students at the universities of Bochum (Germany; 
      n=212) and Tours (France; n=108) regarding end-of-life decisions in medicine was 
      conducted during the last months of their studies. RESULTS: Our results indicate 
      that even though students had training in ethico-legal aspects of end-of-life
      care and participated in clinical practice there is considerable lack of
      knowledge among students with respect to the ethico-legal framework for the
      limitation of treatment at the end of life. CONCLUSION: The study indicates that 
      even with the recent changes in both medical schools there seems to be a further 
      need to prepare students better for end-of-life issues.
FAU - Moehring, Berit
AU  - Moehring B
AD  - Institute for Medical Ethics and History of Medicine, Ruhr-University Bochum,
      Germany.
FAU - Schildmann, Jan
AU  - Schildmann J
FAU - Vollmann, Jochen
AU  - Vollmann J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111003
PL  - United States
TA  - J Palliat Med
JT  - Journal of palliative medicine
JID - 9808462
SB  - IM
MH  - Adult
MH  - Cross-Cultural Comparison
MH  - Education, Medical, Undergraduate/methods/*standards
MH  - Female
MH  - France
MH  - Germany
MH  - Humans
MH  - Male
MH  - Students, Medical/*psychology/statistics & numerical data
MH  - Terminal Care/ethics/methods/*standards
MH  - Young Adult
EDAT- 2011/10/05 06:00
MHDA- 2012/03/06 06:00
CRDT- 2011/10/05 06:00
PHST- 2011/10/05 06:00 [entrez]
PHST- 2011/10/05 06:00 [pubmed]
PHST- 2012/03/06 06:00 [medline]
AID - 10.1089/jpm.2011.0184 [doi]
PST - ppublish
SO  - J Palliat Med. 2011 Nov;14(11):1206-10. doi: 10.1089/jpm.2011.0184. Epub 2011 Oct
      3.


PMID- 21806948
OWN - NLM
STAT- MEDLINE
DCOM- 20120507
LR  - 20220317
IS  - 1523-6536 (Electronic)
IS  - 1083-8791 (Linking)
VI  - 18
IP  - 2
DP  - 2012 Feb
TI  - Easy-to-read informed consent forms for hematopoietic cell transplantation
      clinical trials.
PG  - 183-9
LID - 10.1016/j.bbmt.2011.07.022 [doi]
AB  - Informed consent is essential to ethical research and is requisite to
      participation in clinical research. Yet most hematopoietic cell transplantation
      (HCT) informed consent forms (ICFs) are written at reading levels that are above 
      the ability of the average person in the United States (U.S.). The recent
      development of ICF templates by the National Cancer Institute, National
      Institutes of Health, and the National Heart Blood and Lung Institute have not
      resulted in increased patient comprehension of information. Barriers to creating 
      Easy-to-Read ICFs that meet U.S. federal requirements and pass institutional
      review board (IRB) review are the result of multiple interconnected factors. The 
      Blood and Marrow Transplant Clinical Trials Network (BMT CTN) formed an ad hoc
      review team to address concerns regarding the overall readability and length of
      ICFs used for BMT CTN trials. This paper summarizes recommendations of the review
      team for the development and formatting of Easy-to-Read ICFs for HCT multicenter 
      clinical trials, the most novel of which is the use of a 2-column format. These
      recommendations intend to guide the ICF writing process, simplify local IRB
      review of the ICF, enhance patient comprehension, and improve patient
      satisfaction. The BMT CTN plans to evaluate the impact of the Easy-to-Read format
      compared with the traditional format on the informed consent process.
CI  - Copyright (c) 2012 American Society for Blood and Marrow Transplantation.
      Published by Elsevier Inc. All rights reserved.
FAU - Denzen, Ellen M
AU  - Denzen EM
AD  - National Marrow Donor Program, Patient Services, 3001 Broadway Street NE,
      Minneapolis, MN 55413, USA. edenzen@nmdp.org
FAU - Santibanez, Martha E Burton
AU  - Santibanez ME
FAU - Moore, Heather
AU  - Moore H
FAU - Foley, Amy
AU  - Foley A
FAU - Gersten, Iris D
AU  - Gersten ID
FAU - Gurgol, Cathy
AU  - Gurgol C
FAU - Majhail, Navneet S
AU  - Majhail NS
FAU - Spellecy, Ryan
AU  - Spellecy R
FAU - Horowitz, Mary M
AU  - Horowitz MM
FAU - Murphy, Elizabeth A
AU  - Murphy EA
LA  - eng
GR  - U10 HL069294/HL/NHLBI NIH HHS/United States
GR  - U10 HL069290/HL/NHLBI NIH HHS/United States
GR  - U10 HL069294-11/HL/NHLBI NIH HHS/United States
GR  - U10 HL069330/HL/NHLBI NIH HHS/United States
GR  - U01 HL069294/HL/NHLBI NIH HHS/United States
GR  - U10 HL069348/HL/NHLBI NIH HHS/United States
GR  - U24 CA076518/CA/NCI NIH HHS/United States
GR  - U01HL069294/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20110730
PL  - United States
TA  - Biol Blood Marrow Transplant
JT  - Biology of blood and marrow transplantation : journal of the American Society for
      Blood and Marrow Transplantation
JID - 9600628
SB  - IM
MH  - Clinical Trials as Topic/methods/*standards
MH  - Humans
MH  - Medical Records/*standards
MH  - National Cancer Institute (U.S.)
MH  - National Heart, Lung, and Blood Institute (U.S.)
MH  - United States
PMC - PMC3242929
MID - NIHMS316574
EDAT- 2011/10/05 06:00
MHDA- 2012/05/09 06:00
CRDT- 2011/10/05 06:00
PHST- 2011/05/09 00:00 [received]
PHST- 2011/07/25 00:00 [accepted]
PHST- 2011/10/05 06:00 [entrez]
PHST- 2011/10/05 06:00 [pubmed]
PHST- 2012/05/09 06:00 [medline]
AID - S1083-8791(11)00322-3 [pii]
AID - 10.1016/j.bbmt.2011.07.022 [doi]
PST - ppublish
SO  - Biol Blood Marrow Transplant. 2012 Feb;18(2):183-9. doi:
      10.1016/j.bbmt.2011.07.022. Epub 2011 Jul 30.


PMID- 21966301
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1861-8863 (Electronic)
IS  - 1861-8863 (Linking)
VI  - 7
DP  - 2011
TI  - Individual health services.
PG  - Doc05
LID - 10.3205/hta000096 [doi]
AB  - BACKGROUND: The German statutory health insurance (GKV) reimburses all health
      care services that are deemed sufficient, appropriate, and efficient. According
      to the German Medical Association (BAK), individual health services (IGeL) are
      services that are not under liability of the GKV, medically necessary or
      recommendable or at least justifiable. They have to be explicitly requested by
      the patient and have to be paid out of pocket. RESEARCH QUESTIONS: The following 
      questions regarding IGeL in the outpatient health care of GKV insurants are
      addressed in the present report: What is the empirical evidence regarding offers,
      utilization, practice, acceptance, and the relation between physician and
      patient, as well as the economic relevance of IGeL?What ethical, social, and
      legal aspects are related to IGeL? FOR TWO OF THE MOST COMMON IGEL, THE SCREENING
      FOR GLAUCOMA AND THE SCREENING FOR OVARIAN AND ENDOMETRIAL CANCER BY VAGINAL
      ULTRASOUND (VUS), THE FOLLOWING QUESTIONS ARE ADDRESSED: What is the evidence for
      the clinical effectiveness?Are there sub-populations for whom screening might be 
      beneficial? METHODS: The evaluation is divided into two parts. For the first part
      a systematic literature review of primary studies and publications concerning
      ethical, social and legal aspects is performed. In the second part, rapid
      assessments of the clinical effectiveness for the two examples, glaucoma and VUS 
      screening, are prepared. Therefore, in a first step, HTA-reports and systematic
      reviews are searched, followed by a search for original studies published after
      the end of the research period of the most recent HTA-report included. RESULTS:
      29 studies were included for the first question. Between 19 and 53% of GKV
      members receive IGeL offers, of which three-quarters are realised. 16 to 19% of
      the insurants ask actively for IGeL. Intraocular tension measurement is the most 
      common single IGeL service, accounting for up to 40% of the offers. It is
      followed by ultrasound assessments with up to 25% of the offers. Cancer screening
      and blood or laboratory services are also frequent and represent a major
      proportion of the demand. The ethical, social, and legal aspects discussed in the
      context of IGeL concern eight subject areas: autonomous patient decisions versus 
      obtrusion,commercialization of medicine, duty of patient information, benefit,
      evidence, and (quality) control, role and relation of physicians and
      patients,relation to the GKV, social inequality,formally correct performance. For
      glaucoma screening, no randomized controlled trial (RCT) is identified that shows
      a patient relevant benefit. For VUS three RCT are included. However, they do not 
      yet present mortality data concerning screened and non-screened persons. VUS
      screening shows a high degree of over-diagnosis in turn leading to invasive
      interventions. To diagnose one invasive carcinoma, 30 to 35 surgical procedures
      are necessary. CONCLUSION: IGeL are a relevant factor in the German statutory
      health care system. To provide more transparency, the requests for evidence-based
      and independent patient information should be considered. Whether official
      positive and negative-lists could be an appropriate instrument to give guidance
      to patients and physicians, should be examined. Generally, IGeL must be seen in
      the broader context of the discussions about the future design and development of
      the German health care system.
FAU - Schnell-Inderst, Petra
AU  - Schnell-Inderst P
AD  - Institute of Public Health, Medical Decision Making and Health Technology
      Assessment, Dept. of Public Health and Health Technology Assessment, UMIT -
      University for Health Sciences Medical Informatics and Technology, Hall i.T.,
      Austria.
FAU - Hunger, Theresa
AU  - Hunger T
FAU - Hintringer, Katharina
AU  - Hintringer K
FAU - Schwarzer, Ruth
AU  - Schwarzer R
FAU - Seifert-Klauss, Vanadin Regina
AU  - Seifert-Klauss VR
FAU - Gothe, Holger
AU  - Gothe H
FAU - Wasem, Jurgen
AU  - Wasem J
FAU - Siebert, Uwe
AU  - Siebert U
LA  - eng
PT  - Journal Article
DEP - 20110915
PL  - Germany
TA  - GMS Health Technol Assess
JT  - GMS health technology assessment
JID - 101276045
PMC - PMC3182028
OTO - NOTNLM
OT  - Doctor's duty to give patients information
OT  - EBM
OT  - Federal Joint Commitee
OT  - HTA
OT  - HTA report
OT  - HTA-report
OT  - Peer review
OT  - VUS
OT  - accident
OT  - add-on benefit
OT  - additional benefit
OT  - appropriateness
OT  - benefit package
OT  - biomedical technology assessment
OT  - care
OT  - catalogue of benefits
OT  - catalogue of services
OT  - clinical freedom
OT  - clinical trials as topic
OT  - co-payment
OT  - commercialisation
OT  - commercialization
OT  - controlled clinical trials as topic
OT  - cost analysis
OT  - cost control
OT  - cost effectiveness
OT  - cost reduction
OT  - cost repayment
OT  - cost-benefit analyses
OT  - cost-cutting
OT  - cost-effectiveness
OT  - costs
OT  - costs and cost analysis
OT  - decision making
OT  - demand
OT  - diagnosis
OT  - economic aspect
OT  - economics
OT  - economics, medical
OT  - effectiveness
OT  - efficacy
OT  - efficiency
OT  - endometrial neoplasms
OT  - endometrial neoplasms/economics
OT  - ethics
OT  - evaluation studies as topic
OT  - evidence based medicine
OT  - fee schedule
OT  - freedom of therapy
OT  - glaucoma
OT  - glaucoma/economics
OT  - health care costs/*
OT  - health care costs/*ethics
OT  - health care costs/*standards
OT  - health economic studies
OT  - health economics
OT  - health insurance fund
OT  - health technology assessment
OT  - humans
OT  - individual health services
OT  - insurance benefits
OT  - insurance, health, reimbursement/*
OT  - interview
OT  - interviews as topic
OT  - juricical
OT  - mass screening
OT  - medical assessment
OT  - medical costs
OT  - medical evaluation
OT  - meta analysis as topic
OT  - methods
OT  - obligation to pay
OT  - obligation to render services
OT  - obligation to supply services
OT  - offer
OT  - physician-patient relations/*ethics
OT  - poll
OT  - prevention
OT  - preventive benefits
OT  - preventive services
OT  - private health insurance
OT  - private service
OT  - random
OT  - random allocation
OT  - randomisation
OT  - randomization
OT  - randomized controlled trials as topic
OT  - range of benefits
OT  - reimbursement of costs
OT  - report
OT  - return of costs
OT  - review
OT  - review literature
OT  - review literature as topic
OT  - risk assessment
OT  - screening
OT  - screening for glaucoma
OT  - self retention
OT  - sensitivity
OT  - social economic factors
OT  - socioeconomic factors
OT  - socioeconomics
OT  - specifity
OT  - statutory health insurance
OT  - supplementary benefit
OT  - survey
OT  - systematic review
OT  - technical report
OT  - technology
OT  - technology assessment
OT  - technology assessment, biomedical
OT  - technology evaluation
OT  - technology, medical
OT  - therapy
OT  - treatment
OT  - vaginal ultrasound
EDAT- 2011/10/04 06:00
MHDA- 2011/10/04 06:01
CRDT- 2011/10/04 06:00
PHST- 2011/10/04 06:00 [entrez]
PHST- 2011/10/04 06:00 [pubmed]
PHST- 2011/10/04 06:01 [medline]
AID - 10.3205/hta000096 [doi]
AID - hta000096 [pii]
PST - ppublish
SO  - GMS Health Technol Assess. 2011;7:Doc05. doi: 10.3205/hta000096. Epub 2011 Sep
      15.


PMID- 21966161
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 0975-7406 (Electronic)
IS  - 0975-7406 (Linking)
VI  - 3
IP  - 3
DP  - 2011 Jul
TI  - Drug advertisements published in Indian Medical Journals: Are they ethical?
PG  - 403-6
LID - 10.4103/0975-7406.84449 [doi]
AB  - CONTEXT: It is observed in studies done for western medical journals that
      insufficient information related to drug is usually provided in the drug
      advertisements published in them. AIMS: As data for advertisements published in
      Indian Medical Journals were lacking, this study was designed with the aim of
      evaluating drug advertisements published in Indian Medical Journals for adequacy 
      of information on drug and references given to support the claim made in the
      advertisements. SETTINGS AND DESIGN: Cross-sectional survey. METHODS AND
      MATERIALS: All medical journals related to clinical practice subscribed by the
      Central Library of Government Medical College, Surat, (Indian Journal of
      Pediatrics [IJP], Indian Pediatrics [IP], Journal of the Association of
      Physicians of India [JAPI], Journal of Indian Medical Association [JIMA], Indian 
      Journal of Critical Care Medicine [IJCCM], Indian Journal of Medical and
      Pediatric Oncology [IJMPO], Indian Journal of Gastroenterology [IJG], Indian
      Journal of Ophthalmology [IJO], and Journal of Obstetrics and Gynecology of India
      [JOGI] were evaluated for adequacy of reporting of various parameters in drug
      advertisements published in these journals on the basis of "World Heath
      Organization (WHO)" criteria. References mentioned to support claims were also
      evaluated. STATISTICAL ANALYSIS USED: Descriptive statistics was used to describe
      data as frequencies, percentages, and 95% confidence interval around the
      percentage. RESULTS: Generic name was mentioned in 90% advertisements.
      Indications were mentioned in 84% advertisements. Dose, precautions, and
      contraindications were mentioned in 24%, 17%, and 16% advertisements,
      respectively. Adverse effects and postal address of pharmaceutical company was
      mentioned in 19% and 74% advertisements, respectively. Price was mentioned in
      only 5% advertisements. Only 28% claims were supported by references. Most common
      references were Journal articles (75%). CONCLUSION: Drug advertisements published
      in Indian Medical Journals are poor in reporting various parameters according to 
      WHO criteria.
FAU - Charan, Jaykaran
AU  - Charan J
AD  - Department of Pharmacology, Government Medical College, Surat, Gujarat, India.
FAU - Yadav, Preeti
AU  - Yadav P
FAU - Saxena, Deepak
AU  - Saxena D
FAU - Kantharia, N D
AU  - Kantharia ND
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Pharm Bioallied Sci
JT  - Journal of pharmacy & bioallied sciences
JID - 101537209
PMC - PMC3178947
OTO - NOTNLM
OT  - Drug advertisements
OT  - Indian Medical Journals
OT  - WHO criteria
OT  - ethics
EDAT- 2011/10/04 06:00
MHDA- 2011/10/04 06:01
CRDT- 2011/10/04 06:00
PHST- 2011/01/15 00:00 [received]
PHST- 2011/03/01 00:00 [revised]
PHST- 2011/04/18 00:00 [accepted]
PHST- 2011/10/04 06:00 [entrez]
PHST- 2011/10/04 06:00 [pubmed]
PHST- 2011/10/04 06:01 [medline]
AID - 10.4103/0975-7406.84449 [doi]
AID - JPBS-3-403 [pii]
PST - ppublish
SO  - J Pharm Bioallied Sci. 2011 Jul;3(3):403-6. doi: 10.4103/0975-7406.84449.


PMID- 21966154
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20220321
IS  - 0975-7406 (Electronic)
IS  - 0975-7406 (Linking)
VI  - 3
IP  - 3
DP  - 2011 Jul
TI  - The prevalence of alcohol consumption among the students newly enrolled at a
      public university.
PG  - 345-9
LID - 10.4103/0975-7406.84434 [doi]
AB  - BACKGROUND: Alcohol is the number one toxic substance consumed by people of all
      age groups, which makes its use a public health problem. The overall trend shows 
      that university students are those who suffer the most pressure. OBJECTIVE: To
      assess the prevalence of alcohol use among students newly enrolled at a public
      university in Alagoas, Brazil. MATERIALS AND METHODS: We conducted an analytical 
      sectional study at the Federal University of Alagoas, with 1435 (44% of total)
      newly enrolled students of all courses in 2006. They answered a questionnaire
      based on the CAGE. Some points such as sex, age, marital status, course, housing,
      family characteristics and how drugs fit into in the student life were studied
      with the resources of EpiInfo version 3.3.2. The survey was approved by the
      Research Ethics Committee of the Federal University of Alagoas (number
      000878/2005-17). RESULTS: Of the group studied, 95.9% lived with family and 87.6%
      reported ever drinking alcohol at some time in their life. Of all the
      respondents, 55.4% of men reported having the habit of drinking with friends or
      colleagues (Odds = 0.71; CI = 0.58-0.88; P-value = 0.00088). Among all
      respondents, 17.7% of male students and 9.8% females skipped class after using
      alcohol (Odds = 0.52; CI = 0.38-0.72; P-value = 0.000023). The transition from
      adolescence to youth and study time at university is marked by greater
      vulnerability to alcohol abuse. The family is decisive for the initiation of
      alcohol use, and the university is a factor that increases the possibility of
      maintaining the practice. The fact that not all students were present in the
      classroom at the time of the application questionnaire may have limited the
      search because this was a sectional study. CONCLUSION: Alcohol consumption in
      this university is similar to that in other higher education institutions in the 
      world, which is a cause for concern, since the external lesions are accentuated
      with the practice of using alcohol, characterizing the risk of violence.
FAU - Brandao, Yuri Silva Toledo
AU  - Brandao YS
AD  - Department of Public Health, Faculty of Medicine, Federal University of Alagoas, 
      Campus of Maceio, Maceio-AL, Brazil.
FAU - Correia, Divanise Suruagy
AU  - Correia DS
FAU - de Farias, Maria Stella Jakeline Alves
AU  - de Farias MS
FAU - Antunes, Thallyta Maria Tavares
AU  - Antunes TM
FAU - da Silva, Lais Alves
AU  - da Silva LA
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Pharm Bioallied Sci
JT  - Journal of pharmacy & bioallied sciences
JID - 101537209
PMC - PMC3178940
OTO - NOTNLM
OT  - Alcohol consumption
OT  - drug
OT  - family
OT  - public health
OT  - students
OT  - university
EDAT- 2011/10/04 06:00
MHDA- 2011/10/04 06:01
CRDT- 2011/10/04 06:00
PHST- 2011/05/11 00:00 [received]
PHST- 2011/05/11 00:00 [revised]
PHST- 2011/05/11 00:00 [accepted]
PHST- 2011/10/04 06:00 [entrez]
PHST- 2011/10/04 06:00 [pubmed]
PHST- 2011/10/04 06:01 [medline]
AID - 10.4103/0975-7406.84434 [doi]
AID - JPBS-3-345 [pii]
PST - ppublish
SO  - J Pharm Bioallied Sci. 2011 Jul;3(3):345-9. doi: 10.4103/0975-7406.84434.


PMID- 21965496
OWN - NLM
STAT- MEDLINE
DCOM- 20120227
LR  - 20191210
IS  - 1943-4723 (Electronic)
IS  - 0002-8177 (Linking)
VI  - 142
IP  - 10
DP  - 2011 Oct
TI  - Are advertisements that offer 'free second opinions' ethical?
PG  - 1199-200
FAU - Wentworth, Rod B
AU  - Wentworth RB
AD  - American Dental Association Council on Ethics, Bylaws and Judicial Affairs.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Am Dent Assoc
JT  - Journal of the American Dental Association (1939)
JID - 7503060
SB  - IM
MH  - Advertising/*ethics
MH  - Dental Care/ethics
MH  - Dentists/*ethics
MH  - *Ethics, Dental
MH  - Humans
MH  - Interprofessional Relations/ethics
MH  - Patient Rights
MH  - Personal Autonomy
MH  - Referral and Consultation/*ethics
MH  - Unnecessary Procedures/ethics
EDAT- 2011/10/04 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/10/04 06:00
PHST- 2011/10/04 06:00 [entrez]
PHST- 2011/10/04 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - S0002-8177(14)62798-7 [pii]
AID - 10.14219/jada.archive.2011.0092 [doi]
PST - ppublish
SO  - J Am Dent Assoc. 2011 Oct;142(10):1199-200. doi: 10.14219/jada.archive.2011.0092.


PMID- 21965479
OWN - NLM
STAT- MEDLINE
DCOM- 20120123
LR  - 20151119
IS  - 1651-1905 (Electronic)
IS  - 1403-4948 (Linking)
VI  - 39
IP  - 8
DP  - 2011 Dec
TI  - Why are general practitioners reluctant to enrol patients into a RCT on sick
      leave? A qualitative study.
PG  - 888-93
LID - 10.1177/1403494811424613 [doi]
AB  - AIMS: To explore the reluctance of, and examine the arguments given by Norwegian 
      general practioners (GPs), regarding their unwillingness to recruit their
      patients for a study where sick leave would be based on randomization. METHODS: A
      qualitative study presenting individual arguments from 50 Norwegian GPs, as
      written responses to a web-based, open-ended questionnaire. The responses,
      ranging from 3-145 words, were analysed with systematic text condensation.
      RESULTS: The GPs did not want to participate in a study where sick leave was
      decided by randomization. First, the complexity of clinical judgment was
      addressed. Would it be ethically acceptable to set the professional and medical
      assessment aside, and if so, was there any better judge than the regular GP in
      making this important decision? Second, the arguments dealing with sick leave as 
      a human and legal right were addressed. Will patients feel they have a legitimate
      right to sick leave and will they be open for discussion with their GP? Third,
      the risk of jeopardizing the relationship between patient and doctor was
      emphasized. Would the patients be able to trust their GP if he or she offered the
      patient entry into a trial where sick leave would be decided by randomization?
      CONCLUSIONS: Randomization of sick leave in general practice in Norway was not
      viewed as feasible by the GPs themselves because of the importance of clinical
      judgment, ethical obligations, and the belief that the patients would refuse
      participation, and thereby, that the doctor-patient relationship would be
      disturbed.
FAU - Maeland, Silje
AU  - Maeland S
AD  - Uni Health, Uni Research, Bergen, Norway. Silje.Maeland@uni.no
FAU - Magnussen, Liv H
AU  - Magnussen LH
FAU - Eriksen, Hege R
AU  - Eriksen HR
FAU - Malterud, Kirsti
AU  - Malterud K
LA  - eng
PT  - Journal Article
DEP - 20110929
PL  - Sweden
TA  - Scand J Public Health
JT  - Scandinavian journal of public health
JID - 100883503
SB  - IM
MH  - Adult
MH  - Aged
MH  - Attitude of Health Personnel
MH  - Female
MH  - General Practitioners/ethics/*psychology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Norway
MH  - *Patient Selection/ethics
MH  - Physician-Patient Relations
MH  - Physicians, Family/ethics/psychology
MH  - Qualitative Research
MH  - *Randomized Controlled Trials as Topic/ethics
MH  - *Sick Leave
MH  - Surveys and Questionnaires
EDAT- 2011/10/04 06:00
MHDA- 2012/01/24 06:00
CRDT- 2011/10/04 06:00
PHST- 2011/10/04 06:00 [entrez]
PHST- 2011/10/04 06:00 [pubmed]
PHST- 2012/01/24 06:00 [medline]
AID - 1403494811424613 [pii]
AID - 10.1177/1403494811424613 [doi]
PST - ppublish
SO  - Scand J Public Health. 2011 Dec;39(8):888-93. doi: 10.1177/1403494811424613. Epub
      2011 Sep 29.


PMID- 21964746
OWN - NLM
STAT- MEDLINE
DCOM- 20120809
LR  - 20161125
IS  - 1432-5241 (Electronic)
IS  - 0364-216X (Linking)
VI  - 36
IP  - 2
DP  - 2012 Apr
TI  - Effective wound closure with a new two-component wound closure device (Prineo) in
      excisional body-contouring surgery: experience in over 200 procedures.
PG  - 382-6
LID - 10.1007/s00266-011-9819-4 [doi]
AB  - BACKGROUND: In excisional body-contouring surgery the surgeon is often confronted
      with time-consuming closure of long wounds. Recently, a new combination of a
      self-adhering mesh together with a liquid 2-octyl cyanoacrylate adhesive (Prineo;
      Ethicon, Inc., Somerville, NJ, USA) has been introduced to replace intracutaneous
      running suture. METHODS: An observational study was undertaken to evaluate the
      efficacy of the new wound closure device in excisional body-contouring procedures
      between January 2008 and November 2010. Wound characteristics were recorded in a 
      prospectively maintained database. RESULTS: During the study period, 224
      procedures in 180 patients were undertaken. Twenty-seven patients had two
      subsequent operations and four patients had three subsequent operations.
      Application of the new device was easy and safe and patient satisfaction with the
      results was generally high. However, intense local allergic reactions were seen
      in 4 patients (1.8%), which necessitated early removal and topical corticosteroid
      treatment. CONCLUSIONS: Prineo enables the surgeon to perform a quick and smooth 
      skin closure, especially in long incisions frequently encountered in excisional
      body-contouring surgery. The application is fast and easy if basic guidelines are
      respected. Operating time is saved by eliminating the need for time-consuming
      intracutaneous running sutures. Removal is easy and painless for the patient.
      However, there is a potential for local allergic adverse effects of which the
      surgeon must be aware.
FAU - Huemer, Georg M
AU  - Huemer GM
AD  - Plastic, Aesthetic & Reconstructive Surgery, General Hospital Linz,
      Krankenhausstrasse 9, 4020, Linz, Austria. georg.huemer@maz.at
FAU - Schmidt, Manfred
AU  - Schmidt M
FAU - Helml, Gudrun H
AU  - Helml GH
FAU - Shafighi, Maziar
AU  - Shafighi M
FAU - Dunst-Huemer, Karin M
AU  - Dunst-Huemer KM
LA  - eng
PT  - Journal Article
DEP - 20111001
PL  - United States
TA  - Aesthetic Plast Surg
JT  - Aesthetic plastic surgery
JID - 7701756
RN  - 0 (Cyanoacrylates)
RN  - 0 (Tissue Adhesives)
RN  - 6C655P1XVG (octyl 2-cyanoacrylate)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cyanoacrylates/*administration & dosage
MH  - Humans
MH  - *Lipectomy
MH  - Middle Aged
MH  - Patient Satisfaction
MH  - Surgical Mesh
MH  - Tissue Adhesives/*administration & dosage
MH  - Wound Closure Techniques/*instrumentation
MH  - Wound Healing/physiology
EDAT- 2011/10/04 06:00
MHDA- 2012/08/10 06:00
CRDT- 2011/10/04 06:00
PHST- 2011/05/28 00:00 [received]
PHST- 2011/09/03 00:00 [accepted]
PHST- 2011/10/04 06:00 [entrez]
PHST- 2011/10/04 06:00 [pubmed]
PHST- 2012/08/10 06:00 [medline]
AID - 10.1007/s00266-011-9819-4 [doi]
PST - ppublish
SO  - Aesthetic Plast Surg. 2012 Apr;36(2):382-6. doi: 10.1007/s00266-011-9819-4. Epub 
      2011 Oct 1.


PMID- 21964479
OWN - NLM
STAT- MEDLINE
DCOM- 20120524
LR  - 20120220
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 3
DP  - 2012 Mar
TI  - Egg freezing for non-medical uses: the lack of a relational approach to autonomy 
      in the new Israeli policy and in academic discussion.
PG  - 154-7
LID - 10.1136/medethics-2011-100088 [doi]
AB  - Recently, the Israel National Bioethics Council (INBC) issued recommendations
      permitting egg freezing to prevent both disease- and age-related fertility
      decline. The INBC report forms the basis of Israel's new policy, being one of the
      first countries to regulate and authorise egg freezing for what it considers to
      be non-medical (ie, social) uses. The ethical discussion in the INBC report is
      reviewed and compared with the scant ethical discourse in the academic literature
      on egg freezing as a means of preventing age-related loss of fertility. We argue 
      that both the INBC recommendations and the bioethical academic discourse on egg
      freezing are grounded in liberal ideology, which views technology as primarily
      enabling. Accordingly, they promote 'individual autonomy' as exercised through
      informed consent. Our study suggests that a relational approach to autonomy may
      be a more suitable model for considering women's choices about egg freezing.
FAU - Shkedi-Rafid, Shiri
AU  - Shkedi-Rafid S
AD  - The Institute for Medical Research, Faculty of Medicine, The Hebrew University of
      Jerusalem, Ein Kerem, Jerusalem, Israel. shiri.shkedi@mail.huji.ac.il
FAU - Hashiloni-Dolev, Yael
AU  - Hashiloni-Dolev Y
LA  - eng
PT  - Journal Article
DEP - 20111001
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Age Factors
MH  - Bioethics
MH  - Choice Behavior
MH  - Cryopreservation/*ethics
MH  - Female
MH  - Fertility Preservation/*methods
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Infertility/physiopathology/*therapy
MH  - Israel
MH  - Morals
MH  - Oocytes
MH  - *Personal Autonomy
MH  - Reproductive Behavior/*psychology
EDAT- 2011/10/04 06:00
MHDA- 2012/05/25 06:00
CRDT- 2011/10/04 06:00
PHST- 2011/10/04 06:00 [entrez]
PHST- 2011/10/04 06:00 [pubmed]
PHST- 2012/05/25 06:00 [medline]
AID - medethics-2011-100088 [pii]
AID - 10.1136/medethics-2011-100088 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Mar;38(3):154-7. doi: 10.1136/medethics-2011-100088. Epub 2011
      Oct 1.


PMID- 21964176
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20211020
IS  - 1942-5546 (Electronic)
IS  - 0025-6196 (Linking)
VI  - 86
IP  - 10
DP  - 2011 Oct
TI  - Gastric banding: ethical dilemmas in reviewing body mass index thresholds.
PG  - 999-1001
LID - 10.4065/mcp.2011.0262 [doi]
FAU - Voigt, Kristin
AU  - Voigt K
FAU - Schmidt, Harald
AU  - Schmidt H
LA  - eng
PT  - Letter
PT  - Comment
PL  - England
TA  - Mayo Clin Proc
JT  - Mayo Clinic proceedings
JID - 0405543
SB  - IM
CON - Mayo Clin Proc. 2010 Feb;85(2):112-4. PMID: 20118385
CON - Mayo Clin Proc. 2010 Jul;85(7):605-8. PMID: 20592168
MH  - *Absorptiometry, Photon
MH  - *Body Composition
MH  - *Body Mass Index
MH  - *Cross-Sectional Studies
MH  - *Epidemiologic Studies
MH  - *Heart Failure
MH  - Humans
MH  - Obesity/*complications/*diagnosis
MH  - *Physical Fitness
PMC - PMC3184028
EDAT- 2011/10/04 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/10/04 06:00
PHST- 2011/10/04 06:00 [entrez]
PHST- 2011/10/04 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0025-6196(11)65240-3 [pii]
AID - 10.4065/mcp.2011.0262 [doi]
PST - ppublish
SO  - Mayo Clin Proc. 2011 Oct;86(10):999-1001. doi: 10.4065/mcp.2011.0262.


PMID- 21963670
OWN - NLM
STAT- MEDLINE
DCOM- 20120405
LR  - 20220318
IS  - 1873-7811 (Electronic)
IS  - 0272-7358 (Linking)
VI  - 31
IP  - 8
DP  - 2011 Dec
TI  - Controversy clarified: an updated review of clinical psychology and tele-health.
PG  - 1247-58
LID - 10.1016/j.cpr.2011.08.003 [doi]
AB  - One of the most controversial topics in the field of clinical psychology, online 
      tele-health, or the integration of computers and the internet with therapeutic
      techniques, remains at the forefront of many debates. Despite potential interest,
      there are numerous factors that a psychologist must consider before integrating
      an online tele-health intervention into their own practice. This article outlines
      literature pertinent to the debate. The article begins with a brief history of
      the use of non-face-to-face interventions as well as the earliest recorded use of
      "tele-health" before discussing the modern benefits and risks associated with
      usage. Considerations for the psychologist as well as the client are detailed;
      incorporating ethical implications. The authors conclude that the utilization of 
      tele-health interventions is an exponentially expanding field that should
      continue to be explored. Despite many well-conceived studies, a psychologist
      should educate themselves in all aspects of the new modes of intervention (e.g., 
      ethical, legal, evidence-based treatments) before attempting to implement them
      into everyday practice. The article ends with a discussion on the acceptance
      among psychologists, as well as the outlook for the future.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Perle, Jonathan G
AU  - Perle JG
AD  - Center for Psychological Studies, Nova Southeastern University, 3301 College
      Avenue, Fort Lauderdale, FL 33314, USA. perle@nova.edu
FAU - Langsam, Leah C
AU  - Langsam LC
FAU - Nierenberg, Barry
AU  - Nierenberg B
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110831
PL  - United States
TA  - Clin Psychol Rev
JT  - Clinical psychology review
JID - 8111117
SB  - IM
MH  - Humans
MH  - Internet/*statistics & numerical data
MH  - *Psychology, Clinical/ethics/methods/standards
MH  - *Telemedicine/economics/ethics/methods
EDAT- 2011/10/04 06:00
MHDA- 2012/04/06 06:00
CRDT- 2011/10/04 06:00
PHST- 2011/06/06 00:00 [received]
PHST- 2011/07/26 00:00 [revised]
PHST- 2011/08/24 00:00 [accepted]
PHST- 2011/10/04 06:00 [entrez]
PHST- 2011/10/04 06:00 [pubmed]
PHST- 2012/04/06 06:00 [medline]
AID - S0272-7358(11)00138-3 [pii]
AID - 10.1016/j.cpr.2011.08.003 [doi]
PST - ppublish
SO  - Clin Psychol Rev. 2011 Dec;31(8):1247-58. doi: 10.1016/j.cpr.2011.08.003. Epub
      2011 Aug 31.


PMID- 21962868
OWN - NLM
STAT- MEDLINE
DCOM- 20120410
LR  - 20111206
IS  - 1768-319X (Electronic)
IS  - 0294-1260 (Linking)
VI  - 56
IP  - 6
DP  - 2011 Dec
TI  - [The "double clock" or how to learn microsurgery without animal].
PG  - 555-7
LID - 10.1016/j.anplas.2011.08.014 [doi]
AB  - Animal experimentation is the most common way to learn microsurgery. However,
      this practice should be performed according to ethical rules and financial cost. 
      This study has a triple aim: improving students' skills in microsurgery,
      respecting ethics and reducing costs by using fewer animals. We propose an
      ethical, practical and inexpensive training method that uses sewing needles. This
      training consists in microsurgery wire's passages in the eye of sewing needles
      arranged into circle. Specifically, 24 needles were arranged into two circles on 
      a polystyrene block representing a "double clock". A specific scorecard for this 
      exercise was made to evaluate the students. In total, between November 2010 and
      June 2011, fifteen residents followed the university degree in microsurgery
      provided by the faculty of medicine Henri Warembourg (Lille, France). The "double
      clock" was added to the eight already existing microsurgical manipulations. All
      of the participants were tested and this exercise was found to be effective as a 
      teaching procedure. Also, each student used an average of 20 rats per year. This 
      year we have reduced our animal control by 10% or about 30 rats. Our goals were
      achieved as we have improved student's microsurgical skills and also limiting
      cost by using fewer animals.
CI  - Copyright (c) 2011 Elsevier Masson SAS. All rights reserved.
FAU - Dumont, L-A
AU  - Dumont LA
AD  - Service de chirurgie plastique, hopital Roger-Salengro, CHU de Lille, 2 avenue
      Oscar-Lambret, Lille, France. antoinedumont@live.fr
FAU - Martinot-duquennoy, V
AU  - Martinot-duquennoy V
FAU - Hubert, T
AU  - Hubert T
FAU - Guerreschi, P
AU  - Guerreschi P
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - La "double horloge" ou comment apprendre la microchirurgie sans animal.
DEP - 20110929
PL  - France
TA  - Ann Chir Plast Esthet
JT  - Annales de chirurgie plastique et esthetique
JID - 8305839
SB  - IM
MH  - Animals
MH  - Education, Medical/methods
MH  - General Surgery/*education
MH  - Microsurgery/*education
MH  - Models, Animal
EDAT- 2011/10/04 06:00
MHDA- 2012/04/11 06:00
CRDT- 2011/10/04 06:00
PHST- 2011/08/06 00:00 [received]
PHST- 2011/08/28 00:00 [accepted]
PHST- 2011/10/04 06:00 [entrez]
PHST- 2011/10/04 06:00 [pubmed]
PHST- 2012/04/11 06:00 [medline]
AID - S0294-1260(11)00126-9 [pii]
AID - 10.1016/j.anplas.2011.08.014 [doi]
PST - ppublish
SO  - Ann Chir Plast Esthet. 2011 Dec;56(6):555-7. doi: 10.1016/j.anplas.2011.08.014.
      Epub 2011 Sep 29.


PMID- 21962772
OWN - NLM
STAT- MEDLINE
DCOM- 20120306
LR  - 20111107
IS  - 1472-6491 (Electronic)
IS  - 1472-6483 (Linking)
VI  - 23
IP  - 5
DP  - 2011 Nov
TI  - CBRC and psychosocial counselling: assessing needs and developing an ethical
      framework for practice.
PG  - 642-51
LID - 10.1016/j.rbmo.2011.07.009 [doi]
AB  - Encountering infertility and involuntary childlessness and undergoing infertility
      treatment are acknowledged as stressful experiences that impact on individuals'
      psychological and emotional health - and for which access to psychosocial
      counselling by a skilled mental health professional may be beneficial. Evidence
      of patients', gamete donors' and surrogates' experiences indicates that
      utilization of infertility treatment in another country may not only exacerbate
      these psychosocial adversities, but may also pose additional risks to the
      psychological or physical health of participants, thus further emphasizing the
      need for competent psychosocial counselling services in cross-border reproductive
      care. However, this is a largely neglected topic in recent discussions of both
      CBRC itself and of infertility counselling practice. This paper extends the
      previous work undertaken by two of the authors to begin to map out practice
      issues within an ethical framework for counsellors when working with clients,
      donors, surrogates, individuals conceived following infertility treatment and
      existing children in clients', donor's and surrogates' families where
      cross-border reproductive treatment is considered or undertaken.
CI  - Copyright (c) 2011 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All
      rights reserved.
FAU - Blyth, Eric
AU  - Blyth E
AD  - University of Huddersfield, School of Human and Health Sciences, Queensgate,
      Huddersfield HD1 3DH, United Kingdom. e.d.blyth@hud.ac.uk
FAU - Thorn, Petra
AU  - Thorn P
FAU - Wischmann, Tewes
AU  - Wischmann T
LA  - eng
PT  - Journal Article
DEP - 20110723
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
SB  - IM
MH  - Counseling/*ethics/*methods
MH  - Female
MH  - Humans
MH  - Infertility/*psychology/*therapy
MH  - Male
MH  - Medical Tourism/*ethics
MH  - Patients/psychology
MH  - Psychology
MH  - Reproductive Techniques, Assisted/*ethics
MH  - Surrogate Mothers/psychology
MH  - Tissue Donors/psychology
EDAT- 2011/10/04 06:00
MHDA- 2012/03/07 06:00
CRDT- 2011/10/04 06:00
PHST- 2011/04/14 00:00 [received]
PHST- 2011/05/27 00:00 [revised]
PHST- 2011/07/04 00:00 [accepted]
PHST- 2011/10/04 06:00 [entrez]
PHST- 2011/10/04 06:00 [pubmed]
PHST- 2012/03/07 06:00 [medline]
AID - S1472-6483(11)00413-5 [pii]
AID - 10.1016/j.rbmo.2011.07.009 [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2011 Nov;23(5):642-51. doi: 10.1016/j.rbmo.2011.07.009.
      Epub 2011 Jul 23.


PMID- 21962527
OWN - NLM
STAT- MEDLINE
DCOM- 20120306
LR  - 20120928
IS  - 1472-6491 (Electronic)
IS  - 1472-6483 (Linking)
VI  - 23
IP  - 5
DP  - 2011 Nov
TI  - Banning reproductive travel: Turkey's ART legislation and third-party assisted
      reproduction.
PG  - 555-64
LID - 10.1016/j.rbmo.2011.08.004 [doi]
AB  - In March 2010, Turkey became the first country to legislate against the
      cross-border travel of its citizens seeking third-party reproductive assistance. 
      Although the use of donor eggs, donor spermatozoa and surrogacy had been illegal 
      in Turkey since the introduction of a regulatory framework for assisted
      reproductive treatment in 1987, men and women were free to access these
      treatments in other jurisdictions. In some cases, such travel for cross-border
      reproductive care (CBRC) was even facilitated by sophisticated arrangements
      between IVF clinics in Turkey and in other countries, particularly in Cyprus.
      However, new amendments to Turkey's assisted reproduction legislation
      specifically forbid travel for the purposes of third-party assisted reproduction.
      This article outlines the cultural context of assisted reproductive treatment in 
      Turkey; details the Turkish assisted reproduction legislation, particularly as it
      pertains to third-party reproductive assistance; explores Turkish attitudes
      towards donor gametes and surrogacy; assesses the existence and extent of CBRC
      prior to March 2010; and discusses some of the legal, ethical and practical
      implications of the new legislation. As CBRC becomes an increasingly pertinent
      issue, eliciting debate and discussion at both national and international levels,
      it is important to carefully consider the particular circumstances and potential 
      consequences of this unique example.
CI  - Copyright (c) 2011 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All
      rights reserved.
FAU - Gurtin, Zeynep B
AU  - Gurtin ZB
AD  - Centre for Family Research, Convener, Cambridge Interdisciplinary Reproduction
      Forum, CRASSH, University of Cambridge, Cambridge CB2 3RF, United Kingdom.
      zbg20@cam.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20110827
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
SB  - IM
CIN - Reprod Biomed Online. 2011 Dec;23(7):811-3. PMID: 22056635
CIN - Reprod Biomed Online. 2011 Dec;23(7):814-6. PMID: 22177262
MH  - *Crime
MH  - Female
MH  - *Government Regulation
MH  - Health Care Surveys/methods
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Male
MH  - Marriage/legislation & jurisprudence
MH  - Medical Tourism/*legislation & jurisprudence
MH  - Pregnancy
MH  - Reproductive Techniques, Assisted/*legislation & jurisprudence
MH  - Surrogate Mothers/*legislation & jurisprudence
MH  - Turkey
EDAT- 2011/10/04 06:00
MHDA- 2012/03/07 06:00
CRDT- 2011/10/04 06:00
PHST- 2011/07/18 00:00 [received]
PHST- 2011/08/08 00:00 [revised]
PHST- 2011/08/09 00:00 [accepted]
PHST- 2011/10/04 06:00 [entrez]
PHST- 2011/10/04 06:00 [pubmed]
PHST- 2012/03/07 06:00 [medline]
AID - S1472-6483(11)00470-6 [pii]
AID - 10.1016/j.rbmo.2011.08.004 [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2011 Nov;23(5):555-64. doi: 10.1016/j.rbmo.2011.08.004.
      Epub 2011 Aug 27.


PMID- 21961798
OWN - NLM
STAT- MEDLINE
DCOM- 20111221
LR  - 20211020
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 12
DP  - 2011 Oct 3
TI  - Stakeholders understanding of the concept of benefit sharing in health research
      in Kenya: a qualitative study.
PG  - 20
LID - 10.1186/1472-6939-12-20 [doi]
AB  - BACKGROUND: The concept of benefit sharing to enhance the social value of global 
      health research in resource poor settings is now a key strategy for addressing
      moral issues of relevance to individuals, communities and host countries in
      resource poor settings when they participate in international collaborative
      health research.The influence of benefit sharing framework on the conduct of
      collaborative health research is for instance evidenced by the number of
      publications and research ethics guidelines that require prior engagement between
      stakeholders to determine the social value of research to the host communities.
      While such efforts as the production of international guidance on how to promote 
      the social value of research through such strategies as benefit sharing have been
      made, the extent to which these ideas and guidelines have been absorbed by those 
      engaged in global health research especially in resource poor settings remains
      unclear. We examine this awareness among stakeholders involved in health related 
      research in Kenya. METHODS: We conducted in-depth interviews with key informants 
      drawn from within the broader health research system in Kenya including
      researchers from the mainstream health research institutions, networks and
      universities, teaching hospitals, policy makers, institutional review boards,
      civil society organisations and community representative groups. RESULTS: Our
      study suggests that although people have a sense of justice and the moral aspects
      of research, this was not articulated in terms used in the literature and the
      guidelines on the ethics of global health research. CONCLUSION: This study
      demonstrates that while in theory several efforts can be made to address the
      moral issues of concern to research participants and their communities in
      resource poor settings, quick fixes such as benefit sharing are not going to be
      straightforward. We suggest a need to pay closer attention to the processes
      through which ethical principles are enacted in practice and distil lessons on
      how best to involve individuals and communities in promoting ethical conduct of
      global health research in resource poor settings.
FAU - Lairumbi, Geoffrey M
AU  - Lairumbi GM
AD  - Kemri-Wellcome Trust Research Programme, Centre for Geographic Medicine, Nairobi 
      Unit, P,O Box 43640, 00100, Nairobi, Kenya. lmbaabu@nairobi.kemri-wellcome.org
FAU - Parker, Michael
AU  - Parker M
FAU - Fitzpatrick, Raymond
AU  - Fitzpatrick R
FAU - Mike, English C
AU  - Mike EC
LA  - eng
GR  - 076827/Wellcome Trust/United Kingdom
GR  - 097170/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111003
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Academies and Institutes
MH  - Awareness
MH  - *Biomedical Research
MH  - *Community Participation/trends
MH  - Comprehension
MH  - *Cooperative Behavior
MH  - *Developing Countries/economics
MH  - Ethics Committees, Research
MH  - *Ethics, Research
MH  - Health Policy/trends
MH  - Health Resources
MH  - Health Services Needs and Demand/trends
MH  - Hospitals, Teaching
MH  - Humans
MH  - Kenya
MH  - Narration
MH  - Organizations
MH  - Qualitative Research
MH  - Researcher-Subject Relations/ethics
MH  - *Social Justice
MH  - Social Values
MH  - Surveys and Questionnaires
MH  - Universities
PMC - PMC3200159
EDAT- 2011/10/04 06:00
MHDA- 2011/12/22 06:00
CRDT- 2011/10/04 06:00
PHST- 2010/12/03 00:00 [received]
PHST- 2011/10/03 00:00 [accepted]
PHST- 2011/10/04 06:00 [entrez]
PHST- 2011/10/04 06:00 [pubmed]
PHST- 2011/12/22 06:00 [medline]
AID - 1472-6939-12-20 [pii]
AID - 10.1186/1472-6939-12-20 [doi]
PST - epublish
SO  - BMC Med Ethics. 2011 Oct 3;12:20. doi: 10.1186/1472-6939-12-20.


PMID- 21960416
OWN - NLM
STAT- MEDLINE
DCOM- 20120426
LR  - 20211020
IS  - 1861-0692 (Electronic)
IS  - 1861-0684 (Linking)
VI  - 101
IP  - 1
DP  - 2012 Jan
TI  - Renal sympathetic denervation for treatment of electrical storm: first-in-man
      experience.
PG  - 63-7
LID - 10.1007/s00392-011-0365-5 [doi]
AB  - INTRODUCTION: Sympathetic activity plays an important role in the pathogenesis of
      ventricular tachyarrhythmia. Catheter-based renal sympathetic denervation (RDN)
      is a novel treatment option for patients with resistant hypertension, proved to
      reduce local and whole-body sympathetic activity. METHODS: Two patients with
      chronic heart failure (CHF) (non-obstructive hypertrophic and dilated
      cardiomyopathy, NYHA III) suffering from therapy resistant electrical storm
      underwent therapeutic renal denervation. In both patients, RDN was conducted with
      agreement of the local ethics committee and after obtaining informed consent.
      RESULTS: The patient with hypertrophic cardiomyopathy had recurrent monomorphic
      ventricular tachycardia despite extensive antiarrhythmic therapy, following
      repeated endocardial and epicardial electrophysiological ablation attempts to
      destroy an arrhythmogenic intramural focus in the left ventricle. The second
      patient, with dilated nonischemic cardiomyopathy, suffered from recurrent
      episodes of polymorphic ventricular tachycardia and ventricular fibrillation. The
      patient declined catheter ablation of these tachycardias. In both patients, RDN
      was performed without procedure-related complications. Following RDN, ventricular
      tachyarrhythmias were significantly reduced in both patients. Blood pressure and 
      clinical status remained stable during the procedure and follow-up in these
      patients with CHF. CONCLUSION: Our findings suggest that RDN is feasible even in 
      cardiac unstable patients. Randomized controlled trials are urgently needed to
      study the effects of RD in patients with electrical storm and CHF.
FAU - Ukena, Christian
AU  - Ukena C
AD  - Klinik fur Innere Medizin III (Kardiologie, Angiologie und Internistische
      Intensivmedizin), Universitatsklinikum des Saarlandes, Kirrberger Str. 1, 66421
      Homburg/Saar, Germany. Christian.Ukena@uks.eu
FAU - Bauer, Axel
AU  - Bauer A
FAU - Mahfoud, Felix
AU  - Mahfoud F
FAU - Schreieck, Jurgen
AU  - Schreieck J
FAU - Neuberger, Hans-Ruprecht
AU  - Neuberger HR
FAU - Eick, Christian
AU  - Eick C
FAU - Sobotka, Paul A
AU  - Sobotka PA
FAU - Gawaz, Meinrad
AU  - Gawaz M
FAU - Bohm, Michael
AU  - Bohm M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110929
PL  - Germany
TA  - Clin Res Cardiol
JT  - Clinical research in cardiology : official journal of the German Cardiac Society
JID - 101264123
SB  - IM
MH  - Aged
MH  - Cardiomyopathy, Dilated/physiopathology/*surgery
MH  - Catheter Ablation
MH  - Chronic Disease
MH  - Follow-Up Studies
MH  - Heart Failure/*physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Sympathectomy/*methods
MH  - Tachycardia, Ventricular/physiopathology/*surgery
MH  - Treatment Outcome
EDAT- 2011/10/01 06:00
MHDA- 2012/04/27 06:00
CRDT- 2011/10/01 06:00
PHST- 2011/09/06 00:00 [received]
PHST- 2011/09/15 00:00 [accepted]
PHST- 2011/10/01 06:00 [entrez]
PHST- 2011/10/01 06:00 [pubmed]
PHST- 2012/04/27 06:00 [medline]
AID - 10.1007/s00392-011-0365-5 [doi]
PST - ppublish
SO  - Clin Res Cardiol. 2012 Jan;101(1):63-7. doi: 10.1007/s00392-011-0365-5. Epub 2011
      Sep 29.


PMID- 21960152
OWN - NLM
STAT- MEDLINE
DCOM- 20120524
LR  - 20211020
IS  - 2210-7711 (Electronic)
VI  - 33
IP  - 6
DP  - 2011 Dec
TI  - A comparative pilot study of the professional ethical thinking of Quebec pharmacy
      residents and French pharmacy interns.
PG  - 974-84
LID - 10.1007/s11096-011-9570-6 [doi]
AB  - OBJECTIVE: The main objective of this pilot study is to compare the professional 
      ethical thinking of Quebec pharmacy residents and French pharmacy interns. The
      secondary objective is to compare the professional ethical thinking of Quebec
      pharmacy residents and first year French pharmacy interns. SETTING: Hospital
      pharmacy residents from Quebec, Canada and pharmacy interns from France. METHODS:
      This is a cross-sectional, descriptive, web-based survey. MAIN OUTCOME MEASURE:
      For this study, professional ethical thinking was defined as the level of
      agreement/disagreement with statements about pharmacy ethics/dilemmas. RESULTS: A
      total of 208 usable questionnaires were completed (response rate 91% in Quebec
      and 11% in France). There were no significant differences between Quebec
      residents and French interns for 29/43 items (67%). However, there were
      significant differences in their level of agreement with 14/43 items (33%)
      surveyed by our questionnaire. The differences related to the following themes:
      economic aspects (four statements), pharmaceutical care, code of ethics,
      evaluation, clinical research (two statements each) and training and education,
      dispensing medications (one statement each). There were statistically significant
      differences between the two groups in terms of exposure to ethics during academic
      training and experiential practice. There were significant statistical
      differences between the two groups of first year pharmacy respondents for 11
      statements (26%), with only two out of 11 statements being different from those
      reported in the overall comparison. CONCLUSION: Published data on the
      professional ethical thinking of pharmacy residents and interns remain limited.
      We believe the higher exposure of Quebec residents to ethics during academic
      courses and experiential/practical training may have contributed to a higher
      level of agreement with some ethical statements.
FAU - Scharr, Karin
AU  - Scharr K
AD  - Unite de recherche en pratique pharmaceutique, CHU Sainte-Justine, Montreal, QC, 
      Canada.
FAU - Bussieres, Jean-Francois
AU  - Bussieres JF
FAU - Prot-Labarthe, Sonia
AU  - Prot-Labarthe S
FAU - Bourdon, Olivier
AU  - Bourdon O
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110930
PL  - Netherlands
TA  - Int J Clin Pharm
JT  - International journal of clinical pharmacy
JID - 101554912
SB  - IM
MH  - Adult
MH  - Cross-Sectional Studies
MH  - *Ethics, Pharmacy/education
MH  - Female
MH  - France
MH  - Humans
MH  - Internship, Nonmedical/organization & administration/*statistics & numerical data
MH  - Male
MH  - Pharmacy Service, Hospital/organization & administration
MH  - Pilot Projects
MH  - Quebec
MH  - Students, Pharmacy/*psychology
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2011/10/01 06:00
MHDA- 2012/05/25 06:00
CRDT- 2011/10/01 06:00
PHST- 2010/06/01 00:00 [received]
PHST- 2011/09/17 00:00 [accepted]
PHST- 2011/10/01 06:00 [entrez]
PHST- 2011/10/01 06:00 [pubmed]
PHST- 2012/05/25 06:00 [medline]
AID - 10.1007/s11096-011-9570-6 [doi]
PST - ppublish
SO  - Int J Clin Pharm. 2011 Dec;33(6):974-84. doi: 10.1007/s11096-011-9570-6. Epub
      2011 Sep 30.


PMID- 21959368
OWN - NLM
STAT- MEDLINE
DCOM- 20120216
LR  - 20120829
IS  - 1549-4713 (Electronic)
IS  - 0161-6420 (Linking)
VI  - 119
IP  - 1
DP  - 2012 Jan
TI  - Clinical characteristics in 53 patients with cat scratch optic neuropathy.
PG  - 183-7
LID - 10.1016/j.ophtha.2011.06.042 [doi]
AB  - OBJECTIVE: To describe the clinical manifestations and to identify risk factors
      associated with visual outcome in a large cohort of patients with cat scratch
      optic neuropathy (CSON). DESIGN: Multicenter, retrospective chart review.
      PARTICIPANTS: Fifty-three patients (62 eyes) with serologically positive CSON
      from 5 academic neuro-ophthalmology services evaluated over an 11-year period.
      METHODS: Institutional review board/ethics committee approval was obtained. Data 
      from medical record charts were collected to detail the clinical manifestations
      and to analyze visual outcome metrics. Generalized estimating equations and
      logistic regression analysis were used in the statistical analysis. Six patients 
      (9 eyes) were excluded from visual outcome statistical analysis because of a lack
      of follow-up. MAIN OUTCOME MEASURES: Demographic information, symptoms at
      presentation, clinical characteristics, length of follow-up, treatment used, and 
      visual acuity (at presentation and final follow-up). RESULTS: Mean patient age
      was 27.8 years (range, 8-65 years). Mean follow-up time was 170.8 days (range,
      1-1482 days). Simultaneous bilateral involvement occurred in 9 (17%) of 53
      patients. Visual acuity on presentation ranged from 20/20 to counting fingers
      (mean, 20/160). Sixty-eight percent of eyes retained a visual acuity of 20/40 or 
      better at final follow-up (defined as favorable visual outcome). Sixty-seven
      percent of patients endorsed a history of cat or kitten scratch. Neuroretinitis
      (macular star) developed in 28 eyes (45%). Only 5 patients had significant visual
      complications (branch retinal artery occlusion, macular hole, and corneal
      decompensation). Neither patient age nor any other factor except good initial
      visual acuity and absence of systemic symptoms was associated with a favorable
      visual outcome. There was no association between visual acuity at final follow-up
      and systemic antibiotic or steroid use. CONCLUSIONS: Patients with CSON have a
      good overall visual prognosis. Good visual acuity at presentation was associated 
      with a favorable visual outcome. The absence of a macular star does not exclude
      the possibility of CSON. FINANCIAL DISCLOSURE(S): The author(s) have no
      proprietary or commercial interest in any materials discussed in this article.
CI  - Copyright (c) 2012 American Academy of Ophthalmology. Published by Elsevier Inc. 
      All rights reserved.
FAU - Chi, Sulene L
AU  - Chi SL
AD  - Department of Ophthalmology, Duke Eye Center and Duke University Medical Center, 
      Durham, North Carolina 27710-3802, USA.
FAU - Stinnett, Sandra
AU  - Stinnett S
FAU - Eggenberger, Eric
AU  - Eggenberger E
FAU - Foroozan, Rod
AU  - Foroozan R
FAU - Golnik, Karl
AU  - Golnik K
FAU - Lee, Michael S
AU  - Lee MS
FAU - Bhatti, M Tariq
AU  - Bhatti MT
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20110928
PL  - United States
TA  - Ophthalmology
JT  - Ophthalmology
JID - 7802443
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Antibodies, Bacterial)
RN  - 0 (Glucocorticoids)
SB  - IM
CIN - Ophthalmology. 2012 Jul;119(7):1502-3; author reply1503. PMID: 22749099
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Anti-Bacterial Agents/therapeutic use
MH  - Antibodies, Bacterial/blood
MH  - Bartonella henselae/immunology/isolation & purification
MH  - Cat-Scratch Disease/*diagnosis/drug therapy/microbiology
MH  - Child
MH  - Eye Infections, Bacterial/*diagnosis/drug therapy/microbiology
MH  - Female
MH  - Fluorescent Antibody Technique, Indirect
MH  - Glucocorticoids/therapeutic use
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Optic Nerve Diseases/*diagnosis/drug therapy/microbiology
MH  - Prognosis
MH  - Retinitis/diagnosis/drug therapy/microbiology
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Vision Disorders/diagnosis/drug therapy/microbiology
MH  - Visual Acuity/physiology
EDAT- 2011/10/01 06:00
MHDA- 2012/02/18 06:00
CRDT- 2011/10/01 06:00
PHST- 2011/02/18 00:00 [received]
PHST- 2011/06/29 00:00 [revised]
PHST- 2011/06/29 00:00 [accepted]
PHST- 2011/10/01 06:00 [entrez]
PHST- 2011/10/01 06:00 [pubmed]
PHST- 2012/02/18 06:00 [medline]
AID - S0161-6420(11)00621-X [pii]
AID - 10.1016/j.ophtha.2011.06.042 [doi]
PST - ppublish
SO  - Ophthalmology. 2012 Jan;119(1):183-7. doi: 10.1016/j.ophtha.2011.06.042. Epub
      2011 Sep 28.


PMID- 21959337
OWN - NLM
STAT- MEDLINE
DCOM- 20120302
LR  - 20161125
IS  - 1873-2380 (Electronic)
IS  - 0021-9290 (Linking)
VI  - 44
IP  - 16
DP  - 2011 Nov 10
TI  - The effect of decreasing computed tomography dosage on radiostereometric analysis
      (RSA) accuracy at the glenohumeral joint.
PG  - 2847-50
LID - 10.1016/j.jbiomech.2011.08.009 [doi]
AB  - Standard, beaded radiostereometric analysis (RSA) and markerless RSA often use
      computed tomography (CT) scans to create three-dimensional (3D) bone models.
      However, ethical concerns exist due to risks associated with CT radiation
      exposure. Therefore, the aim of this study was to investigate the effect of
      decreasing CT dosage on RSA accuracy. Four cadaveric shoulder specimens were
      scanned using a normal-dose CT protocol and two low-dose protocols, where the
      dosage was decreased by 89% and 98%. 3D computer models of the humerus and
      scapula were created using each CT protocol. Bi-planar fluoroscopy was used to
      image five different static glenohumeral positions and two dynamic glenohumeral
      movements, of which a total of five static and four dynamic poses were selected
      for analysis. For standard RSA, negligible differences were found in bead
      (0.21+/-0.31mm) and bony landmark (2.31+/-1.90mm) locations when the CT dosage
      was decreased by 98% (p-values>0.167). For markerless RSA kinematic results,
      excellent agreement was found between the normal-dose and lowest-dose protocol,
      with all Spearman rank correlation coefficients greater than 0.95. Average root
      mean squared errors of 1.04+/-0.68mm and 2.42+/-0.81 degrees were also found at
      this reduced dosage for static positions. In summary, CT dosage can be markedly
      reduced when performing shoulder RSA to minimize the risks of radiation exposure.
      Standard RSA accuracy was negligibly affected by the 98% CT dose reduction and
      for markerless RSA, the benefits of decreasing CT dosage to the subject outweigh 
      the introduced errors.
CI  - Copyright A(c) 2011 Elsevier Ltd. All rights reserved.
FAU - Fox, Anne-Marie V
AU  - Fox AM
AD  - Wolf Orthopaedic Biomechanics Lab, Fowler Kennedy Sport Medicine Clinic, The
      University of Western Ontario, London, Ontario, Canada.
FAU - Kedgley, Angela E
AU  - Kedgley AE
FAU - Lalone, Emily A
AU  - Lalone EA
FAU - Johnson, James A
AU  - Johnson JA
FAU - Athwal, George S
AU  - Athwal GS
FAU - Jenkyn, Thomas R
AU  - Jenkyn TR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110929
PL  - United States
TA  - J Biomech
JT  - Journal of biomechanics
JID - 0157375
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - Humerus/*diagnostic imaging
MH  - Male
MH  - *Radiation Dosage
MH  - Scapula/*diagnostic imaging
MH  - Shoulder Joint/*diagnostic imaging
MH  - Tomography, X-Ray Computed/adverse effects/*methods
EDAT- 2011/10/01 06:00
MHDA- 2012/03/03 06:00
CRDT- 2011/10/01 06:00
PHST- 2011/05/23 00:00 [received]
PHST- 2011/08/10 00:00 [revised]
PHST- 2011/08/11 00:00 [accepted]
PHST- 2011/10/01 06:00 [entrez]
PHST- 2011/10/01 06:00 [pubmed]
PHST- 2012/03/03 06:00 [medline]
AID - S0021-9290(11)00557-4 [pii]
AID - 10.1016/j.jbiomech.2011.08.009 [doi]
PST - ppublish
SO  - J Biomech. 2011 Nov 10;44(16):2847-50. doi: 10.1016/j.jbiomech.2011.08.009. Epub 
      2011 Sep 29.


PMID- 21958467
OWN - NLM
STAT- MEDLINE
DCOM- 20121217
LR  - 20181201
IS  - 1934-8150 (Electronic)
IS  - 1551-7411 (Linking)
VI  - 8
IP  - 4
DP  - 2012 Jul-Aug
TI  - Organizational factors influencing pharmacy practice change.
PG  - 274-84
LID - 10.1016/j.sapharm.2011.07.002 [doi]
AB  - BACKGROUND: Some pharmacists have changed the focus of their practice from solely
      dispensing. Emerging services they have added include medication therapy
      management and other pharmacy services. OBJECTIVE: To assess the effect of
      entrepreneurial orientation, resource adequacy, and pharmacy staffing on pharmacy
      practice change. METHODS: A total of 1847 licensed U.S. pharmacists received 2
      mail surveys as part of a larger national pharmacist survey. The core survey
      collected information about practice setting, prescription volume, and staffing. 
      The supplemental survey assessed how the pharmacy had changed over the past 2
      years to enable the delivery of pharmacy services. The amount of change was
      assessed by 12 items, which were summed to provide an aggregate change index.
      Five variables from organizational change literature were assessed as influences 
      on practice change: proactiveness, risk taking, autonomy, work ethic, and
      adequacy of resources. In addition, the associations of pharmacist and technician
      staffing with practice change were assessed. A multiple linear regression
      analysis was performed with the aggregate change index as the dependent variable 
      and the 7 potential influences on change as the independent variables. RESULTS:
      Four hundred usable surveys were analyzed. At least some level of practice change
      was reported in 60% of pharmacies surveyed. The linear regression analysis of the
      model was significant (P<.001) with an R-square value of 0.276. Significant
      influences on change were 2 dimensions of entrepreneurial
      orientation-proactiveness and autonomy-as well as adequacy of resources and
      pharmacy technician staffing. CONCLUSIONS: Many pharmacies reported that some
      aspects of their practice have changed, such as collecting patient information
      and documenting care. Few reported changes in asking patients to pay for pharmacy
      services. These findings support previous results, which show that the capacity
      for organizational change can be augmented by increasing proactiveness, autonomy 
      among employees, and the availability of adequate and appropriate resources.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Doucette, William R
AU  - Doucette WR
AD  - Division of Clinical and Administrative Pharmacy, College of Pharmacy, University
      of Iowa, Iowa City, IA 52242, USA. william-doucette@uiowa.edu
FAU - Nevins, Justin C
AU  - Nevins JC
FAU - Gaither, Caroline
AU  - Gaither C
FAU - Kreling, David H
AU  - Kreling DH
FAU - Mott, David A
AU  - Mott DA
FAU - Pedersen, Craig A
AU  - Pedersen CA
FAU - Schommer, Jon C
AU  - Schommer JC
LA  - eng
PT  - Journal Article
DEP - 20110929
PL  - United States
TA  - Res Social Adm Pharm
JT  - Research in social & administrative pharmacy : RSAP
JID - 101231974
SB  - IM
CIN - Res Social Adm Pharm. 2012 Jul-Aug;8(4):269-71. PMID: 22840188
MH  - Attitude of Health Personnel
MH  - Delivery of Health Care/economics/*organization & administration
MH  - Drug Prescriptions
MH  - Health Care Surveys
MH  - Health Knowledge, Attitudes, Practice
MH  - Health Services Research
MH  - Humans
MH  - Least-Squares Analysis
MH  - Linear Models
MH  - Medication Therapy Management/organization & administration
MH  - Organizational Innovation
MH  - Organizational Objectives
MH  - Personnel Staffing and Scheduling/organization & administration
MH  - Pharmaceutical Services/economics/*organization & administration
MH  - Pharmacists/economics/*organization & administration/psychology
MH  - Pharmacy Technicians/organization & administration
MH  - Practice Management/economics/*organization & administration
MH  - Professional Autonomy
MH  - Risk-Taking
MH  - Surveys and Questionnaires
MH  - Time Factors
MH  - United States
MH  - Workforce
EDAT- 2011/10/01 06:00
MHDA- 2012/12/18 06:00
CRDT- 2011/10/01 06:00
PHST- 2010/12/30 00:00 [received]
PHST- 2011/07/07 00:00 [revised]
PHST- 2011/07/07 00:00 [accepted]
PHST- 2011/10/01 06:00 [entrez]
PHST- 2011/10/01 06:00 [pubmed]
PHST- 2012/12/18 06:00 [medline]
AID - S1551-7411(11)00079-9 [pii]
AID - 10.1016/j.sapharm.2011.07.002 [doi]
PST - ppublish
SO  - Res Social Adm Pharm. 2012 Jul-Aug;8(4):274-84. doi:
      10.1016/j.sapharm.2011.07.002. Epub 2011 Sep 29.


PMID- 21958221
OWN - NLM
STAT- MEDLINE
DCOM- 20120112
LR  - 20211203
IS  - 1471-2474 (Electronic)
IS  - 1471-2474 (Linking)
VI  - 12
DP  - 2011 Sep 29
TI  - Double-plating of ovine critical sized defects of the tibia: a low morbidity
      model enabling continuous in vivo monitoring of bone healing.
PG  - 214
LID - 10.1186/1471-2474-12-214 [doi]
AB  - BACKGROUND: Recent studies using sheep critical sized defect models to test
      tissue engineered products report high morbidity and complications rates. This
      study evaluates a large bone defect model in the sheep tibia, stabilized with
      two, a novel Carbon fibre Poly-ether-ether-ketone (CF-PEEK) and a locking
      compression plate (LCP) which could sustain duration for up to 6 month with an
      acceptable low complication rate. METHODS: A large bone defect of 3 cm was
      performed in the mid diaphysis of the right tibia in 33 sheep. The defect was
      stabilised with the CF - PEEK plate and an LCP. All sheep were supported with
      slings for 8 weeks after surgery. The study was carried out for 3 months in 6 and
      for 6 months in 27 animals. RESULTS: The surgical procedure could easily be
      performed in all sheep and continuous in vivo radiographic evaluation of the
      defect was possible. This long bone critical sized defect model shows with 6.1% a
      low rate of complications compared with numbers mentioned in the literature.
      CONCLUSIONS: This experimental animal model could serve as a standard model in
      comparative research. A well defined standard model would reduce the number of
      experimental animals needed in future studies and would therefore add to ethical 
      considerations.
FAU - Hahn, Joachim A
AU  - Hahn JA
AD  - AO Research Institute, Davos, Switzerland. ja.hahn@web.de
FAU - Witte, Tanja S
AU  - Witte TS
FAU - Arens, Daniel
AU  - Arens D
FAU - Pearce, Alexandra
AU  - Pearce A
FAU - Pearce, Simon
AU  - Pearce S
LA  - eng
PT  - Journal Article
DEP - 20110929
PL  - England
TA  - BMC Musculoskelet Disord
JT  - BMC musculoskeletal disorders
JID - 100968565
RN  - 0 (Benzophenones)
RN  - 0 (Biocompatible Materials)
RN  - 0 (Ketones)
RN  - 0 (Polymers)
RN  - 31694-16-3 (polyetheretherketone)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 7440-44-0 (Carbon)
SB  - IM
MH  - Animal Use Alternatives
MH  - Animals
MH  - Benzophenones
MH  - Biocompatible Materials/adverse effects
MH  - *Bone Plates
MH  - Carbon
MH  - Diaphyses/diagnostic imaging/injuries/surgery
MH  - Disease Models, Animal
MH  - Fracture Fixation, Internal/*instrumentation/*methods
MH  - Fracture Healing/drug effects/physiology
MH  - Ketones/adverse effects
MH  - Longevity/drug effects
MH  - Osteogenesis/drug effects/physiology
MH  - Polyethylene Glycols/adverse effects
MH  - Polymers
MH  - Postoperative Complications
MH  - Prosthesis Design
MH  - Radiography
MH  - Sheep
MH  - Tibia/diagnostic imaging/injuries/*surgery
PMC - PMC3195802
EDAT- 2011/10/01 06:00
MHDA- 2012/01/13 06:00
CRDT- 2011/10/01 06:00
PHST- 2011/06/02 00:00 [received]
PHST- 2011/09/29 00:00 [accepted]
PHST- 2011/10/01 06:00 [entrez]
PHST- 2011/10/01 06:00 [pubmed]
PHST- 2012/01/13 06:00 [medline]
AID - 1471-2474-12-214 [pii]
AID - 10.1186/1471-2474-12-214 [doi]
PST - epublish
SO  - BMC Musculoskelet Disord. 2011 Sep 29;12:214. doi: 10.1186/1471-2474-12-214.


PMID- 21958096
OWN - NLM
STAT- MEDLINE
DCOM- 20120203
LR  - 20220317
IS  - 1744-8379 (Electronic)
IS  - 1473-7167 (Linking)
VI  - 11
IP  - 5
DP  - 2011 Oct
TI  - Using health technology assessment to support evidence-based decision-making in
      Canada: an academic perspective.
PG  - 513-21
LID - 10.1586/erp.11.60 [doi]
AB  - Health technology assessment (HTA) adopts a multidisciplinary approach to
      comprehensively assess safety, efficacy, effectiveness, economic and
      organizational impact, and any potential social and ethical implications
      associated with adoption and diffusion of a technology in a healthcare system.
      Canada was one of the first pioneers in using HTA as a research tool to support
      evidence-based decision-making. This article describes the current application of
      HTA in Canada, with a focus on some federal and Ontario initiatives in which the 
      authors have extensive knowledge and experience to illustrate how academic
      researchers conduct HTA in collaboration with decision makers. Some issues and
      challenges are also highlighted that will hopefully stimulate a broader
      discussion among HTA stakeholders to move HTA forward.
FAU - Xie, Feng
AU  - Xie F
AD  - Department of Clinical Epidemiology and Biostatistics, Faculty of Health
      Sciences, McMaster University, Hamilton, ON, Canada. fengxie@mcmaster.ca
FAU - Bowen, James M
AU  - Bowen JM
FAU - Sutherland, Simone C
AU  - Sutherland SC
FAU - Burke, Natasha
AU  - Burke N
FAU - Blackhouse, Gord
AU  - Blackhouse G
FAU - Tarride, Jean-Eric
AU  - Tarride JE
FAU - O'Reilly, Daria
AU  - O'Reilly D
FAU - Goeree, Ron
AU  - Goeree R
LA  - eng
PT  - Journal Article
PL  - England
TA  - Expert Rev Pharmacoecon Outcomes Res
JT  - Expert review of pharmacoeconomics & outcomes research
JID - 101132257
SB  - IM
MH  - *Biomedical Technology
MH  - Canada
MH  - *Decision Making
MH  - Delivery of Health Care
MH  - *Evidence-Based Medicine
MH  - Humans
MH  - *Technology Assessment, Biomedical
EDAT- 2011/10/01 06:00
MHDA- 2012/02/04 06:00
CRDT- 2011/10/01 06:00
PHST- 2011/10/01 06:00 [entrez]
PHST- 2011/10/01 06:00 [pubmed]
PHST- 2012/02/04 06:00 [medline]
AID - 10.1586/erp.11.60 [doi]
PST - ppublish
SO  - Expert Rev Pharmacoecon Outcomes Res. 2011 Oct;11(5):513-21. doi:
      10.1586/erp.11.60.


PMID- 21957785
OWN - NLM
STAT- MEDLINE
DCOM- 20111103
LR  - 20110930
IS  - 0040-4284 (Print)
IS  - 0040-4284 (Linking)
VI  - 128
IP  - 8
DP  - 2011 Aug
TI  - The judicial process: an overview from the TDA Council on Ethics and Judicial
      Affairs.
PG  - 734-9
AB  - From time to time, the Council on Ethics and Judicial Affairs must investigate
      and act on the alleged unethical behavior of Texas Dental Association members.
      Because the alleged behavior is directed at a colleague and TDA member, the work 
      of the council is neither comfortable nor inviting. Nonetheless, council
      decisions are made taking into account its mission to investigate the allegation 
      between the parties and to improve dental ethics in the state.
FAU - Burk, Roy N
AU  - Burk RN
AD  - University of Texas Dental Branch at Houston, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Tex Dent J
JT  - Texas dental journal
JID - 2984821R
MH  - Codes of Ethics/legislation & jurisprudence
MH  - Dental Care/ethics
MH  - Dentist-Patient Relations/ethics
MH  - Dentists/*ethics/legislation & jurisprudence
MH  - Ethical Review
MH  - Ethics Committees/*legislation & jurisprudence
MH  - *Ethics, Dental
MH  - Humans
MH  - Interprofessional Relations/ethics
MH  - Peer Review/ethics
MH  - Quality of Health Care/ethics
MH  - Social Responsibility
MH  - Societies, Dental/*ethics/legislation & jurisprudence
MH  - Texas
EDAT- 2011/10/01 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/10/01 06:00
PHST- 2011/10/01 06:00 [entrez]
PHST- 2011/10/01 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
PST - ppublish
SO  - Tex Dent J. 2011 Aug;128(8):734-9.


PMID- 21957784
OWN - NLM
STAT- MEDLINE
DCOM- 20111103
LR  - 20110930
IS  - 0040-4284 (Print)
IS  - 0040-4284 (Linking)
VI  - 128
IP  - 8
DP  - 2011 Aug
TI  - ADA Principles of Ethics and Code of Professional Conduct.
PG  - 728-32
FAU - McCarley, David H
AU  - McCarley DH
AD  - Baylor College of Dentistry, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Tex Dent J
JT  - Texas dental journal
JID - 2984821R
MH  - *American Dental Association
MH  - Beneficence
MH  - *Codes of Ethics/legislation & jurisprudence
MH  - Ethics Committees
MH  - Humans
MH  - Interprofessional Relations
MH  - Morals
MH  - Personal Autonomy
MH  - Professional Competence
MH  - Social Justice
MH  - Social Responsibility
MH  - Truth Disclosure
MH  - United States
EDAT- 2011/10/01 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/10/01 06:00
PHST- 2011/10/01 06:00 [entrez]
PHST- 2011/10/01 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
PST - ppublish
SO  - Tex Dent J. 2011 Aug;128(8):728-32.


PMID- 21957783
OWN - NLM
STAT- MEDLINE
DCOM- 20111103
LR  - 20110930
IS  - 0040-4284 (Print)
IS  - 0040-4284 (Linking)
VI  - 128
IP  - 8
DP  - 2011 Aug
TI  - The journey beyond silos. Teaching and learning interprofessional ethics at
      UTHealth.
PG  - 716-26
AB  - Interprofessional education and ethics education are two educational programs
      that blend together well, and, moreover, they are a natural fit for teaching in
      an academic health science center. The purpose of this paper is to describe our
      recent journey of developing and implementing an interprofessional ethics
      curriculum across the six schools of UTHealth. We provide an overview of the
      goals of the Campus-wide Ethics Program, which is housed in the McGovern Center
      for Humanities and Ethics, and we highlight certain innovative developments that 
      are the result of the collaborative work of faculty and administrators from all
      six schools of UTHealth. In addition, a brief synopsis of the specific didactic
      and clinical courses in which ethics is a significant component is outlined for
      both the dental and the dental hygiene curricula. Lastly, we describe some of the
      recent scholarly activities that are a product of this new program. We are
      excited about our evolving efforts and the potential benefits of weaving
      interprofessional ethics within our school and across our campus. This article
      tells the story of our journey beyond "the silos" that are common among academic 
      health science centers.
FAU - Flaitz, Catherine M
AU  - Flaitz CM
AD  - Department of Diagnostic Sciences, University of Texas Health Science Center at
      Houston (UTHealth) School of Dentistry, Houston, Texas, USA.
FAU - Carlin, Nathan
AU  - Carlin N
FAU - Shepherd, Boyd W
AU  - Shepherd BW
FAU - McWherter, Jayne A
AU  - McWherter JA
FAU - Bebermeyer, Richard D
AU  - Bebermeyer RD
FAU - Walji, Muhammad F
AU  - Walji MF
FAU - Spike, Jeffrey
AU  - Spike J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Tex Dent J
JT  - Texas dental journal
JID - 2984821R
MH  - *Academic Medical Centers/organization & administration
MH  - Administrative Personnel
MH  - Cooperative Behavior
MH  - Curriculum
MH  - Dental Hygienists/education/ethics
MH  - Ethics, Dental/education
MH  - Ethics, Professional/*education
MH  - Faculty
MH  - Humans
MH  - *Learning
MH  - Moral Development
MH  - Organizational Innovation
MH  - Organizational Objectives
MH  - Problem-Based Learning
MH  - Professional Competence
MH  - Program Development
MH  - Schools, Dental/organization & administration
MH  - Schools, Health Occupations/organization & administration
MH  - Staff Development
MH  - Teaching/*methods
MH  - Texas
EDAT- 2011/10/01 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/10/01 06:00
PHST- 2011/10/01 06:00 [entrez]
PHST- 2011/10/01 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
PST - ppublish
SO  - Tex Dent J. 2011 Aug;128(8):716-26.


PMID- 21957782
OWN - NLM
STAT- MEDLINE
DCOM- 20111103
LR  - 20110930
IS  - 0040-4284 (Print)
IS  - 0040-4284 (Linking)
VI  - 128
IP  - 8
DP  - 2011 Aug
TI  - Teaching ethics and change.
PG  - 708-13
FAU - Cobb, Stanton W
AU  - Cobb SW
AD  - Baylor College of Dentistry-Texas A&M Health Science Center, Dallas, Texas, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Tex Dent J
JT  - Texas dental journal
JID - 2984821R
MH  - Attitude of Health Personnel
MH  - Character
MH  - Cognition/physiology
MH  - Conscience
MH  - Dentists/ethics
MH  - *Education, Dental
MH  - Emotions
MH  - Ethics, Dental/*education
MH  - Humans
MH  - Moral Development
MH  - Social Environment
MH  - Social Responsibility
MH  - Students, Dental
MH  - United States
MH  - Virtues
EDAT- 2011/10/01 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/10/01 06:00
PHST- 2011/10/01 06:00 [entrez]
PHST- 2011/10/01 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
PST - ppublish
SO  - Tex Dent J. 2011 Aug;128(8):708-13.


PMID- 21957781
OWN - NLM
STAT- MEDLINE
DCOM- 20111103
LR  - 20131121
IS  - 0040-4284 (Print)
IS  - 0040-4284 (Linking)
VI  - 128
IP  - 8
DP  - 2011 Aug
TI  - Ethics education in undergraduate pre-health programs. The contribution of
      undergraduate colleges and universities to the ethical and moral development of
      future doctors in the medical and dental professions.
PG  - 698-706
AB  - There are many barriers to ethics education of students attending medical and
      dental schools. The question is asked, "Should more attention be given to
      addressing students' ethics education during their undergraduate years of
      preparation for professional healthcare programs?" This qualitative study
      utilizes digitally recorded personal interviews with two undergraduate
      pre-healthcare students, one medical student, one recently matriculated dental
      student, one undergraduate pre-healthcare faculty member, three dental school
      faculty members, and three medical school faculty members. Interview participants
      discuss areas of personal knowledge and experience concerning: the admissions
      process and screening of potential medical/dental students for ethical traits and
      behaviors, influences on student ethical development, undergraduate
      pre-healthcare ethics training, and preferred college major for pre-healthcare
      students. The study concludes that undergraduate pre-healthcare programs should
      take the initiative to be proactive and deliberate in strengthening the positive 
      influences on students. Strategies include: 1) humanities curricula to broaden
      perspectives and increase non-prejudice; 2) mentoring and modeling by older
      students, faculty, and community and professional volunteers; 3) ethical case
      study discussions in class or extracurricular activities; and 4)
      volunteer/service learning activities. Additionally, curriculum learning is
      enhanced by the use of reflection and writing, discussions, and media.
FAU - Erratt, Tamie D
AU  - Erratt TD
AD  - Abilene Christian University, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Tex Dent J
JT  - Texas dental journal
JID - 2984821R
MH  - Curriculum
MH  - *Education, Predental
MH  - *Education, Premedical
MH  - *Ethics, Dental
MH  - *Ethics, Medical
MH  - Ethics, Professional/*education
MH  - Faculty
MH  - Faculty, Dental
MH  - Faculty, Medical
MH  - Humanities/education
MH  - Humans
MH  - Mentors
MH  - *Moral Development
MH  - Morals
MH  - School Admission Criteria
MH  - Social Welfare/ethics
MH  - Students, Dental
MH  - Students, Medical
MH  - Teaching/methods
MH  - United States
MH  - Universities
MH  - Volunteers
EDAT- 2011/10/01 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/10/01 06:00
PHST- 2011/10/01 06:00 [entrez]
PHST- 2011/10/01 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
PST - ppublish
SO  - Tex Dent J. 2011 Aug;128(8):698-706.


PMID- 21957779
OWN - NLM
STAT- MEDLINE
DCOM- 20111103
LR  - 20110930
IS  - 0040-4284 (Print)
IS  - 0040-4284 (Linking)
VI  - 128
IP  - 8
DP  - 2011 Aug
TI  - Dental ethics "the strength of our profession".
PG  - 692
FAU - Matteson, Stephen R
AU  - Matteson SR
LA  - eng
PT  - Editorial
PT  - Introductory Journal Article
PL  - United States
TA  - Tex Dent J
JT  - Texas dental journal
JID - 2984821R
MH  - Dentists/ethics
MH  - *Ethics, Dental
MH  - Humans
MH  - Professional Competence/standards
MH  - United States
EDAT- 2011/10/01 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/10/01 06:00
PHST- 2011/10/01 06:00 [entrez]
PHST- 2011/10/01 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
PST - ppublish
SO  - Tex Dent J. 2011 Aug;128(8):692.


PMID- 21957545
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20110930
IS  - 1173-2032 (Print)
IS  - 1173-2032 (Linking)
VI  - 17
IP  - 7
DP  - 2011 Aug
TI  - Nurses have an ethical imperative to minimise procedural pain.
PG  - 12-4
FAU - Shaw, Susan
AU  - Shaw S
AD  - Faculty of Health and Environmental Sciences, AUT University.
FAU - Lamdin, Rain
AU  - Lamdin R
LA  - eng
PT  - Journal Article
PL  - New Zealand
TA  - Nurs N Z
JT  - Nursing New Zealand (Wellington, N.Z. : 1995)
JID - 9507374
MH  - Adult
MH  - Analgesia/*nursing
MH  - Child
MH  - Clinical Competence
MH  - *Ethics, Nursing
MH  - Humans
MH  - New Zealand
MH  - Nursing Staff/*ethics/standards
MH  - Pain/*nursing/*prevention & control
EDAT- 2011/10/01 06:00
MHDA- 2011/10/25 06:00
CRDT- 2011/10/01 06:00
PHST- 2011/10/01 06:00 [entrez]
PHST- 2011/10/01 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
PST - ppublish
SO  - Nurs N Z. 2011 Aug;17(7):12-4.


PMID- 21957523
OWN - NLM
STAT- MEDLINE
DCOM- 20111013
LR  - 20161125
IS  - 0954-7762 (Print)
IS  - 0954-7762 (Linking)
VI  - 107
IP  - 30-31
DP  - 2011 Aug 2-15
TI  - Why do I have to apply for ethical approval before I can begin my research?
PG  - 23
FAU - Gelling, Leslie
AU  - Gelling L
AD  - Anglia Ruskin University Cambridge.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Times
JT  - Nursing times
JID - 0423236
MH  - *Clinical Trials as Topic
MH  - *Ethics, Nursing
MH  - *Nursing Research
MH  - United Kingdom
EDAT- 2011/10/01 06:00
MHDA- 2011/10/14 06:00
CRDT- 2011/10/01 06:00
PHST- 2011/10/01 06:00 [entrez]
PHST- 2011/10/01 06:00 [pubmed]
PHST- 2011/10/14 06:00 [medline]
PST - ppublish
SO  - Nurs Times. 2011 Aug 2-15;107(30-31):23.


PMID- 21957435
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 1871-4757 (Print)
IS  - 1871-4757 (Linking)
VI  - 5
IP  - 2
DP  - 2011 Aug
TI  - Assessing Expectations: Towards a Toolbox for an Ethics of Emerging Technologies.
PG  - 129-141
AB  - In recent years, several authors have argued that the desirability of novel
      technologies should be assessed early, when they are still emerging. Such an
      ethical assessment of emerging technologies is by definition focused on an
      elusive object. Usually promises, expectations, and visions of the technology are
      taken as a starting point. As Nordmann and Rip have pointed out in a recent
      article, however, ethicists should not take for granted the plausibility of such 
      expectations and visions. In this paper, we explore how the quality of
      expectations on emerging technologies might be assessed when engaging in a
      reflection on the desirability of emerging technologies. We propose that an
      assessment of expectations' plausibility should focus on statements on
      technological feasibility, societal usability, and desirability of the expected
      technology. Whereas the feasibility statement and, to a lesser extent, the
      usability statements are frequently quite futuristic, the claims on desirability,
      by contrast, often display a conservative stance towards the future. Assessing
      the quality of expectations and visions on behalf of emerging technologies
      requires, then, a careful and well-directed use of both skepticism and
      imagination. We conclude with a brief overview of the tools and methods ethicists
      could use to assess claims made on behalf of emerging technologies and improve
      the ethical reflection on them.
FAU - Lucivero, Federica
AU  - Lucivero F
FAU - Swierstra, Tsjalling
AU  - Swierstra T
FAU - Boenink, Marianne
AU  - Boenink M
LA  - eng
PT  - Journal Article
DEP - 20110709
PL  - Netherlands
TA  - Nanoethics
JT  - Nanoethics
JID - 101311055
PMC - PMC3166601
EDAT- 2011/10/01 06:00
MHDA- 2011/10/01 06:01
CRDT- 2011/09/30 06:00
PHST- 2011/01/18 00:00 [received]
PHST- 2011/06/01 00:00 [accepted]
PHST- 2011/09/30 06:00 [entrez]
PHST- 2011/10/01 06:00 [pubmed]
PHST- 2011/10/01 06:01 [medline]
AID - 10.1007/s11569-011-0119-x [doi]
AID - 119 [pii]
PST - ppublish
SO  - Nanoethics. 2011 Aug;5(2):129-141. doi: 10.1007/s11569-011-0119-x. Epub 2011 Jul 
      9.


PMID- 21957381
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 0976-2361 (Electronic)
IS  - 0976-2361 (Linking)
VI  - 2
IP  - 2
DP  - 2011 Apr
TI  - Editorial policy in reporting ethical processes: A survey of 'instructions for
      authors' in International Indexed Dental Journals.
PG  - 84-7
LID - 10.4103/0976-237X.83066 [doi]
AB  - BACKGROUND: The International Committee of Medical Journal Editors expects
      authors to report if their studies were carried out in accordance with the
      International Ethical Guidelines and Declaration of Helsinki; and inform readers 
      regarding the same. AIMS: To determine the proportion of International Indexed
      Dental Journals reporting on ethical clearance for human and animal research,
      obtaining of informed consent and / or assent, and the conduction of research in 
      accordance with the Declaration of Helsinki and International Medical Research,
      2006. SETTINGS AND DESIGN: A cross-sectional survey of 'instructions for
      authors,' for analysis of editorial policy on ethical processes, was done.
      MATERIALS AND METHODS: One hundred and twenty-six dental journals (which included
      50 general and 76 specialties) were reviewed for reporting, with regard to the
      Ethical Committee Approval for human and animal researches, obtaining of informed
      consent / assent from the research participants, and research in accordance with 
      the Declaration of Helsinki as well as International Medical Research 2006 were
      analyzed. STATISTICAL ANALYSIS USED: Descriptive statistics was used and results 
      were expressed in percentages. RESULTS: Of the 126 dental journals, 57 (45.23%)
      reported having obtained approval from the Ethics Committee, 33 (26.19%) were
      instructed about the Animal Ethics Committee approval, and 38 (30.15%) insisted
      on obtaining and reporting informed consent / assent. 41 (32.53%) journals
      expected authors to mention the research being conducted according to Declaration
      of Helsinki and and 3 (2.38%) journals required researches to be conducted in
      accordance with International Medical Research, 2006. CONCLUSIONS: A significant 
      proportion of international indexed dental journals did not provide instructions 
      to authors to report on the ethical approval, informed consent and / assent, and 
      research conduction according to the Declaration of Helsinki as well as the
      International Medical Research, 2006.
FAU - Navaneetha, Cugati
AU  - Navaneetha C
AD  - Department of Pedodontics and Preventive Dentistry, Sri Venkateshwara Dental
      College and Hospital, Anekal Road, Banerghatta, Bangalore, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Contemp Clin Dent
JT  - Contemporary clinical dentistry
JID - 101552967
PMC - PMC3180841
OTO - NOTNLM
OT  - Authors
OT  - ethics
OT  - publication
OT  - research
EDAT- 2011/10/01 06:00
MHDA- 2011/10/01 06:01
CRDT- 2011/09/30 06:00
PHST- 2011/09/30 06:00 [entrez]
PHST- 2011/10/01 06:00 [pubmed]
PHST- 2011/10/01 06:01 [medline]
AID - 10.4103/0976-237X.83066 [doi]
AID - CCD-2-84 [pii]
PST - ppublish
SO  - Contemp Clin Dent. 2011 Apr;2(2):84-7. doi: 10.4103/0976-237X.83066.


PMID- 21957167
OWN - NLM
STAT- MEDLINE
DCOM- 20120426
LR  - 20110929
IS  - 1946-6242 (Electronic)
IS  - 1946-6234 (Linking)
VI  - 3
IP  - 102
DP  - 2011 Sep 28
TI  - Disclosure of clinical trial results when product development is abandoned.
PG  - 102cm29
LID - 10.1126/scitranslmed.3002939 [doi]
AB  - Currently, sponsors are not required to report the outcomes of clinical research 
      on drugs or devices that do not lead to an approved product. Consequently, the
      public cannot benefit from scientific information derived from all failed or
      abandoned drugs and devices. Provisions in the U.S. Food and Drug Administration 
      Amendments Act of 2007 provide an opportunity for the Department of Health and
      Human Services to rectify this situation. By reporting the results of clinical
      trials of abandoned products in a publicly accessible database and in the
      peer-reviewed journal literature, sponsors would satisfy a core ethical
      obligation of clinical research and enhance translational science.
FAU - Rogawski, Michael A
AU  - Rogawski MA
AD  - Department of Neurology, School of Medicine, University of California, Davis,
      Sacramento, CA 95817, USA. rogawski@ucdavis.edu
FAU - Federoff, Howard J
AU  - Federoff HJ
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
PL  - United States
TA  - Sci Transl Med
JT  - Science translational medicine
JID - 101505086
SB  - IM
MH  - *Clinical Trials as Topic
MH  - *Disclosure
MH  - *Drug Approval
MH  - Humans
MH  - Periodicals as Topic
MH  - Publication Bias
MH  - *Treatment Failure
EDAT- 2011/10/01 06:00
MHDA- 2012/04/27 06:00
CRDT- 2011/09/30 06:00
PHST- 2011/09/30 06:00 [entrez]
PHST- 2011/10/01 06:00 [pubmed]
PHST- 2012/04/27 06:00 [medline]
AID - 3/102/102cm29 [pii]
AID - 10.1126/scitranslmed.3002939 [doi]
PST - ppublish
SO  - Sci Transl Med. 2011 Sep 28;3(102):102cm29. doi: 10.1126/scitranslmed.3002939.


PMID- 21956976
OWN - NLM
STAT- MEDLINE
DCOM- 20130522
LR  - 20220414
IS  - 1099-1611 (Electronic)
IS  - 1057-9249 (Linking)
VI  - 22
IP  - 1
DP  - 2013 Jan
TI  - Work stress and well-being in oncology settings: a multidisciplinary study of
      health care professionals.
PG  - 46-53
LID - 10.1002/pon.2055 [doi]
AB  - OBJECTIVES: Staff working in oncology report high levels of work-related stress. 
      This arises partly from the nature of clinical work, including practitioner
      perceptions of high demand and low control or high effort and low reward. This
      comparative study investigated the correlates of work stress in a
      multidisciplinary group of staff and the associations between staff perceptions
      of the work environment, emotional distress, job satisfaction and work-based
      social support. METHODS: This questionnaire study combined quantitative and
      qualitative assessment in a cohort sample of multidisciplinary staff (N = 85)
      working in a cancer centre in North East Scotland. Ethical approval was granted
      by the local Research Ethics Committee. This paper reports on the quantitative
      element of the study, RESULTS: Response rate was 50.6% (N = 85). Older, female
      and nursing and support staff were more likely to participate. Support staff
      reported the lowest perceptions of control, job satisfaction and managerial
      support. Radiographers reported the highest levels of job satisfaction, co-worker
      and managerial support. Nurses perceived lower decision control and job
      satisfaction than allied health professionals or doctors. In general, perceptions
      of decisional control and reward were protective of job satisfaction,
      particularly when work demands were high. Co-worker support was associated with
      perceptions of reduced effort, greater reward and increased satisfaction.
      Managerial support was also associated with greater control beliefs. Overall,
      sickness absence exceeded the 5% rates seen in other National Health Service
      surveys, whereas turnover intention rates were similar. CONCLUSION: The
      development and introduction of multilevel strategies to reduce demand, improve
      control and support perceptions are warranted, particularly for support staff.
CI  - Copyright (c) 2011 John Wiley & Sons, Ltd.
FAU - Jones, Martyn C
AU  - Jones MC
AD  - School of Nursing and Midwifery, Alliance for Self Care Research, University of
      Dundee, Dundee, UK. m.c.jones@dundee.ac.uk
FAU - Wells, Mary
AU  - Wells M
FAU - Gao, Chuan
AU  - Gao C
FAU - Cassidy, Bernadette
AU  - Cassidy B
FAU - Davie, Jackie
AU  - Davie J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110928
PL  - England
TA  - Psychooncology
JT  - Psycho-oncology
JID - 9214524
SB  - IM
MH  - Adult
MH  - Attitude of Health Personnel
MH  - Burnout, Professional/psychology
MH  - Female
MH  - Health Facility Environment
MH  - Health Personnel/*psychology
MH  - Humans
MH  - Job Satisfaction
MH  - Male
MH  - Occupational Health
MH  - Oncology Service, Hospital/*organization & administration
MH  - Patient Care Team
MH  - Perception
MH  - Personal Satisfaction
MH  - Personnel Turnover
MH  - Scotland
MH  - Socioeconomic Factors
MH  - *Stress, Psychological
MH  - Surveys and Questionnaires
MH  - Work Schedule Tolerance/psychology
MH  - Workplace/*psychology
EDAT- 2011/10/01 06:00
MHDA- 2013/05/23 06:00
CRDT- 2011/09/30 06:00
PHST- 2011/02/22 00:00 [received]
PHST- 2011/07/07 00:00 [revised]
PHST- 2011/07/21 00:00 [accepted]
PHST- 2011/09/30 06:00 [entrez]
PHST- 2011/10/01 06:00 [pubmed]
PHST- 2013/05/23 06:00 [medline]
AID - 10.1002/pon.2055 [doi]
PST - ppublish
SO  - Psychooncology. 2013 Jan;22(1):46-53. doi: 10.1002/pon.2055. Epub 2011 Sep 28.


PMID- 21956700
OWN - NLM
STAT- MEDLINE
DCOM- 20120208
LR  - 20111011
IS  - 1572-8633 (Electronic)
IS  - 1386-7423 (Linking)
VI  - 14
IP  - 4
DP  - 2011 Nov
TI  - Human enhancement: revisiting the ethical framework.
PG  - 425-7
LID - 10.1007/s11019-011-9350-z [doi]
FAU - Essmann, Boris
AU  - Essmann B
AD  - Department of Medical Ethics and the History of Medicine, University of Freiburg,
      Freiburg im Breisgau, Germany. essmann@egm.uni-freiburg.de
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Med Health Care Philos
JT  - Medicine, health care, and philosophy
JID - 9815900
SB  - IM
MH  - *Bioethics
MH  - Biomedical Enhancement/*ethics
MH  - Humans
EDAT- 2011/10/01 06:00
MHDA- 2012/02/09 06:00
CRDT- 2011/09/30 06:00
PHST- 2011/09/30 06:00 [entrez]
PHST- 2011/10/01 06:00 [pubmed]
PHST- 2012/02/09 06:00 [medline]
AID - 10.1007/s11019-011-9350-z [doi]
PST - ppublish
SO  - Med Health Care Philos. 2011 Nov;14(4):425-7. doi: 10.1007/s11019-011-9350-z.


PMID- 21956582
OWN - NLM
STAT- MEDLINE
DCOM- 20120601
LR  - 20211020
IS  - 1970-9366 (Electronic)
IS  - 1828-0447 (Linking)
VI  - 7
IP  - 1
DP  - 2012 Feb
TI  - Herbal remedies: science or tradition? The ethical dilemma.
PG  - 91-2; author reply 93-4
LID - 10.1007/s11739-011-0695-3 [doi]
FAU - Beton, Osman
AU  - Beton O
FAU - Yilmaz, Mehmet Birhan
AU  - Yilmaz MB
FAU - Tandogan, Izzet
AU  - Tandogan I
LA  - eng
PT  - Letter
PT  - Comment
DEP - 20110929
PL  - Italy
TA  - Intern Emerg Med
JT  - Internal and emergency medicine
JID - 101263418
SB  - IM
CON - Intern Emerg Med. 2011 Dec;6(6):575-6. PMID: 21638059
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - *Herbal Medicine
MH  - *Hospitals
MH  - Humans
MH  - *Inpatients
MH  - Male
MH  - *Practice Patterns, Physicians'
EDAT- 2011/10/01 06:00
MHDA- 2012/06/02 06:00
CRDT- 2011/09/30 06:00
PHST- 2011/07/10 00:00 [received]
PHST- 2011/09/13 00:00 [accepted]
PHST- 2011/09/30 06:00 [entrez]
PHST- 2011/10/01 06:00 [pubmed]
PHST- 2012/06/02 06:00 [medline]
AID - 10.1007/s11739-011-0695-3 [doi]
PST - ppublish
SO  - Intern Emerg Med. 2012 Feb;7(1):91-2; author reply 93-4. doi:
      10.1007/s11739-011-0695-3. Epub 2011 Sep 29.


PMID- 21956411
OWN - NLM
STAT- MEDLINE
DCOM- 20120209
LR  - 20131106
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 96
IP  - 12
DP  - 2011 Dec
TI  - Clinical review: Ethical and medical considerations of androgen deprivation
      treatment of sex offenders.
PG  - 3628-37
LID - 10.1210/jc.2011-1540 [doi]
AB  - CONTEXT: Blood testosterone codetermines the threshold for erotosexual imagery
      and sexual activity. Androgen deprivation may therefore have a place in the
      treatment of unacceptable sexual behavior. Although androgen deprivation can be
      effective for sex offenders, their basic human rights must be respected;
      otherwise such treatment constitutes a violation of their physical integrity and 
      is ethically unacceptable. As experience in treating prostate cancers
      demonstrates, androgen deprivation may have serious side effects.
      Endocrinologists are qualified to advise on and monitor androgen deprivation, but
      they are placed in an atypical position because the indication for such treatment
      is not dictated by endocrine disease. OBJECTIVE: The aim of this study was to
      provide an ethical framework for advising on androgen deprivation treatment of
      sex offenders and dealing with side effects. EVIDENCE ACQUISITION AND SYNTHESIS: 
      A literature search was conducted in PubMed, Psychinfo, and references from the
      multiple systematic reviews and meta-analyses published on this topic. An attempt
      has been made to provide an appreciation of the ethical aspects of androgen
      deprivation in sex offenders, the efficacy of treatment, the potential risks of
      treatment, therapeutic options, and recommendations for monitoring treatment.
      CONCLUSIONS: Provided that the human rights of sex offenders are respected and
      informed consent is given, androgen deprivation within a comprehensive framework 
      of psychotherapeutic treatment can make a meaningful contribution to the
      prevention of recidivism by enabling better control of sexual impulses. Knowledge
      of side effects and their treatment has been mostly gleaned from experience with 
      prostate cancer patients, and this should be made available to sex offenders
      undergoing androgen deprivation.
FAU - Gooren, Louis J
AU  - Gooren LJ
AD  - VU University Medical Center, 1081 HV Amsterdam, The Netherlands.
      louisjgooren@gmail.com
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110928
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Androgen Antagonists)
SB  - IM
MH  - Androgen Antagonists/adverse effects/*therapeutic use
MH  - *Criminals
MH  - Fractures, Bone/chemically induced
MH  - *Human Rights
MH  - Humans
MH  - Male
MH  - Morals
MH  - Sex Offenses/*prevention & control
EDAT- 2011/10/01 06:00
MHDA- 2012/02/10 06:00
CRDT- 2011/09/30 06:00
PHST- 2011/09/30 06:00 [entrez]
PHST- 2011/10/01 06:00 [pubmed]
PHST- 2012/02/10 06:00 [medline]
AID - jc.2011-1540 [pii]
AID - 10.1210/jc.2011-1540 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2011 Dec;96(12):3628-37. doi: 10.1210/jc.2011-1540. Epub
      2011 Sep 28.


PMID- 21956309
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20211203
IS  - 1476-4687 (Electronic)
IS  - 0028-0836 (Linking)
VI  - 477
IP  - 7366
DP  - 2011 Sep 28
TI  - Aboriginal genome analysis comes to grips with ethics.
PG  - 522-3
LID - 10.1038/477522a [doi]
FAU - Callaway, Ewen
AU  - Callaway E
LA  - eng
PT  - News
DEP - 20110928
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
SB  - IM
CIN - Nature. 2011 Oct 27;478(7370):458-9. PMID: 22031428
MH  - Australia/ethnology
MH  - Emigration and Immigration
MH  - Genetic Privacy/ethics
MH  - Genetic Variation/genetics
MH  - Genome, Human/*genetics
MH  - Genomics/*ethics/standards
MH  - Geography
MH  - Guidelines as Topic
MH  - Hair/metabolism
MH  - Humans
MH  - Informed Consent/ethics
MH  - Museums
MH  - Native Hawaiian or Other Pacific Islander/ethnology/*genetics
MH  - Sequence Analysis, DNA
EDAT- 2011/10/01 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/09/30 06:00
PHST- 2011/09/30 06:00 [entrez]
PHST- 2011/10/01 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - 477522a [pii]
AID - 10.1038/477522a [doi]
PST - epublish
SO  - Nature. 2011 Sep 28;477(7366):522-3. doi: 10.1038/477522a.


PMID- 21955955
OWN - NLM
STAT- MEDLINE
DCOM- 20120524
LR  - 20211020
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 3
DP  - 2012 Mar
TI  - Challenges of genetic testing in adolescents with cardiac arrhythmia syndromes.
PG  - 163-7
LID - 10.1136/medethics-2011-100087 [doi]
AB  - The ability to sequence individual genomes is leading to the identification of an
      increasing number of genetic risk factors for serious diseases. Knowledge of
      these risk factors can often provide significant medical and psychological
      benefit, but also raises complex ethical and social issues. This paper focuses on
      one area of rapid progress: the identification of mutations causing long QT
      syndrome and other cardiac channel disorders, which can explain some previously
      unexplained deaths in infants (SIDS) and children and adults (SUDS) and prevent
      others from occurring. This genetic knowledge, discovered posthumously in many
      cases, has implications for clinical care for surviving family members who might 
      carry the same mutations. The information obtained from genetic testing, in the
      context of personal and family history, can guide individually tailored
      interventions that reduce risk and save lives. At the same time, obtaining and
      disclosing genetic information raises difficult issues about confidentiality and 
      decision making within families. We draw on the experience of the
      Montefiore-Einstein Center for Cardiogenetics, which has played a leading role in
      the genetic diagnosis and clinical management of cardiac channel diseases, to
      explore some of the challenging ethical questions arising in affected families
      with adolescent children. We focus on the related issues of (1) family
      confidentiality, privacy and disclosure and (2) adolescent decision making about 
      genetic risk, and argue for the value of interdisciplinary dialogue with affected
      families in resolving these issues.
FAU - Cohen, Lilian Liou
AU  - Cohen LL
AD  - Department of Pediatrics, Division of Medical Genetics, Weill Cornell Medical
      College/New York Presbyterian Hospital, NY 10021, USA. lilianlioucohen@yahoo.com
FAU - Stolerman, Marina
AU  - Stolerman M
FAU - Walsh, Christine
AU  - Walsh C
FAU - Wasserman, David
AU  - Wasserman D
FAU - Dolan, Siobhan M
AU  - Dolan SM
LA  - eng
GR  - RC1 HL100756/HL/NHLBI NIH HHS/United States
GR  - RC1 HL100756-02/HL/NHLBI NIH HHS/United States
GR  - R01HL100756/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110927
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Arrhythmias, Cardiac/diagnosis/*genetics
MH  - Confidentiality
MH  - Conflict, Psychological
MH  - Decision Making
MH  - Disclosure
MH  - Family/*psychology
MH  - Genetic Counseling
MH  - Genetic Testing/*ethics
MH  - Humans
MH  - Infant
MH  - Mutation
MH  - Privacy
MH  - Psychology, Adolescent
MH  - Risk Reduction Behavior
MH  - Sudden Infant Death/diagnosis/genetics
PMC - PMC3258368
MID - NIHMS329081
EDAT- 2011/10/01 06:00
MHDA- 2012/05/25 06:00
CRDT- 2011/09/30 06:00
PHST- 2011/09/30 06:00 [entrez]
PHST- 2011/10/01 06:00 [pubmed]
PHST- 2012/05/25 06:00 [medline]
AID - medethics-2011-100087 [pii]
AID - 10.1136/medethics-2011-100087 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Mar;38(3):163-7. doi: 10.1136/medethics-2011-100087. Epub 2011
      Sep 27.


PMID- 21955738
OWN - NLM
STAT- MEDLINE
DCOM- 20120124
LR  - 20151119
IS  - 1878-3503 (Electronic)
IS  - 0035-9203 (Linking)
VI  - 105
IP  - 12
DP  - 2011 Dec
TI  - Scientists and public involvement: a consultation on the relation between
      malaria, vector control and transgenic mosquitoes.
PG  - 704-10
LID - 10.1016/j.trstmh.2011.08.006 [doi]
AB  - Among the hopes for vector-based malaria control, the use of transgenic
      mosquitoes able to kill malaria parasites is seen as a potential way to interrupt
      malaria transmission. While this potential solution is gaining some support, the 
      ethical and social aspects related to this high-tech method remain largely
      unexplored and underestimated. Related to those latter points, the aim of the
      present survey is to determine how scientists working on malaria and its vector
      mosquitoes perceive public opinion and how they evaluate public consultations on 
      their research. This study has been performed through a questionnaire addressing 
      questions related to the type of research, the location, the nationality and the 
      perception of the public involvement by scientists. The results suggest that even
      if malaria researchers agree to interact with a non-scientific audience, they
      (especially the ones from the global North) remain quite reluctant to have their 
      research project submitted in a jargon-free version to the evaluation and the
      prior-agreement by a group of non-specialists. The study, by interrogating the
      links between the scientific community and the public from the perspective of the
      scientists, reveals the importance of fostering structures and processes that
      could lead to a better involvement of a non specialist public in the actual
      debates linking scientific, technological and public health issues in Africa.
CI  - Copyright (c) 2011 Royal Society of Tropical Medicine and Hygiene. Published by
      Elsevier Ltd. All rights reserved.
FAU - Boete, Christophe
AU  - Boete C
AD  - American University of Paris, Department of Computer Science, Mathematics and
      Science, Paris, France. cboete@gmail.com
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110928
PL  - England
TA  - Trans R Soc Trop Med Hyg
JT  - Transactions of the Royal Society of Tropical Medicine and Hygiene
JID - 7506129
SB  - IM
MH  - Africa/epidemiology
MH  - Animals
MH  - Animals, Genetically Modified/parasitology
MH  - *Culicidae/genetics/parasitology
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Malaria/epidemiology/*prevention & control
MH  - Mosquito Control/ethics/*methods
MH  - *Public Opinion
MH  - Qualitative Research
MH  - *Research Personnel
MH  - Surveys and Questionnaires
EDAT- 2011/10/01 06:00
MHDA- 2012/01/25 06:00
CRDT- 2011/09/30 06:00
PHST- 2011/04/21 00:00 [received]
PHST- 2011/08/12 00:00 [revised]
PHST- 2011/08/12 00:00 [accepted]
PHST- 2011/09/30 06:00 [entrez]
PHST- 2011/10/01 06:00 [pubmed]
PHST- 2012/01/25 06:00 [medline]
AID - S0035-9203(11)00167-2 [pii]
AID - 10.1016/j.trstmh.2011.08.006 [doi]
PST - ppublish
SO  - Trans R Soc Trop Med Hyg. 2011 Dec;105(12):704-10. doi:
      10.1016/j.trstmh.2011.08.006. Epub 2011 Sep 28.


PMID- 21955451
OWN - NLM
STAT- MEDLINE
DCOM- 20111214
LR  - 20211020
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 12
DP  - 2011 Sep 28
TI  - Be known, be available, be mutual: a qualitative ethical analysis of social
      values in rural palliative care.
PG  - 19
LID - 10.1186/1472-6939-12-19 [doi]
AB  - BACKGROUND: Although attention to healthcare ethics in rural areas has increased,
      specific focus on rural palliative care is still largely under-studied and
      under-theorized. The purpose of this study was to gain a deeper understanding of 
      the values informing good palliative care from rural individuals' perspectives.
      METHODS: We conducted a qualitative ethnographic study in four rural communities 
      in Western Canada. Each community had a population of 10, 000 or less and was
      located at least a three hour travelling distance by car from a specialist
      palliative care treatment centre. Data were collected over a 2-year period and
      included 95 interviews, 51 days of field work and 74 hours of direct participant 
      observation where the researchers accompanied rural healthcare providers. Data
      were analyzed inductively to identify the most prevalent thematic values, and
      then coded using NVivo. RESULTS: This study illuminated the core values of
      knowing and being known, being present and available, and community and mutuality
      that provide the foundation for ethically good rural palliative care. These
      values were congruent across the study communities and across the stakeholders
      involved in rural palliative care. Although these were highly prized values, each
      came with a corresponding ethical tension. Being known often resulted in a loss
      of privacy. Being available and present created a high degree of expectation and 
      potential caregiver strain. The values of community and mutuality created
      entitlement issues, presenting daunting challenges for coordinated change.
      CONCLUSIONS: The values identified in this study offer the opportunity to better 
      understand common ethical tensions that arise in rural healthcare and key
      differences between rural and urban palliative care. In particular, these values 
      shed light on problematic health system and health policy changes. When
      initiatives violate deeply held values and hard won rural capacity to address the
      needs of their dying members is undermined, there are long lasting negative
      consequences. The social fabric of rural life is frayed. These findings offer one
      way to re-conceptualize healthcare decision making through consideration of
      critical values to support ethically good palliative care in rural settings.
FAU - Pesut, Barbara
AU  - Pesut B
AD  - School of Nursing, University of British Columbia Okanagan, Kelowna, BC, Canada. 
      barb.pesut@ubc.ca
FAU - Bottorff, Joan L
AU  - Bottorff JL
FAU - Robinson, Carole A
AU  - Robinson CA
LA  - eng
GR  - EOG 90308/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110928
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Canada
MH  - Ethical Analysis
MH  - Health Policy/trends
MH  - Health Services Accessibility/*ethics/standards/trends
MH  - *Health Services Needs and Demand
MH  - Humans
MH  - Palliative Care/*ethics/trends
MH  - Qualitative Research
MH  - *Rural Population
MH  - Social Values/*ethnology
PMC - PMC3195725
EDAT- 2011/10/01 06:00
MHDA- 2011/12/15 06:00
CRDT- 2011/09/30 06:00
PHST- 2011/03/28 00:00 [received]
PHST- 2011/09/28 00:00 [accepted]
PHST- 2011/09/30 06:00 [entrez]
PHST- 2011/10/01 06:00 [pubmed]
PHST- 2011/12/15 06:00 [medline]
AID - 1472-6939-12-19 [pii]
AID - 10.1186/1472-6939-12-19 [doi]
PST - epublish
SO  - BMC Med Ethics. 2011 Sep 28;12:19. doi: 10.1186/1472-6939-12-19.


PMID- 21955348
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20220316
IS  - 1756-994X (Electronic)
IS  - 1756-994X (Linking)
VI  - 3
IP  - 9
DP  - 2011 Sep 28
TI  - Developing and implementing an institute-wide data sharing policy.
PG  - 60
LID - 10.1186/gm276 [doi]
AB  - The Wellcome Trust Sanger Institute has a strong reputation for prepublication
      data sharing as a result of its policy of rapid release of genome sequence data
      and particularly through its contribution to the Human Genome Project. The
      practicalities of broad data sharing remain largely uncharted, especially to
      cover the wide range of data types currently produced by genomic studies and to
      adequately address ethical issues. This paper describes the processes and
      challenges involved in implementing a data sharing policy on an institute-wide
      scale. This includes questions of governance, practical aspects of applying
      principles to diverse experimental contexts, building enabling systems and
      infrastructure, incentives and collaborative issues.
FAU - Dyke, Stephanie Om
AU  - Dyke SO
AD  - Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge
      CB10 1SA, UK. th@sanger.ac.uk.
FAU - Hubbard, Tim Jp
AU  - Hubbard TJ
LA  - eng
PT  - Journal Article
DEP - 20110928
PL  - England
TA  - Genome Med
JT  - Genome medicine
JID - 101475844
PMC - PMC3239235
EDAT- 2011/10/01 06:00
MHDA- 2011/10/01 06:01
CRDT- 2011/09/30 06:00
PHST- 2011/09/30 06:00 [entrez]
PHST- 2011/10/01 06:00 [pubmed]
PHST- 2011/10/01 06:01 [medline]
AID - gm276 [pii]
AID - 10.1186/gm276 [doi]
PST - epublish
SO  - Genome Med. 2011 Sep 28;3(9):60. doi: 10.1186/gm276.


PMID- 21955332
OWN - NLM
STAT- MEDLINE
DCOM- 20120626
LR  - 20120305
IS  - 1465-3362 (Electronic)
IS  - 0959-5236 (Linking)
VI  - 31
IP  - 2
DP  - 2012 Mar
TI  - Guidelines for pregnancy: what's an acceptable risk, and how is the evidence
      (finally) shaping up?
PG  - 170-83
LID - 10.1111/j.1465-3362.2011.00331.x [doi]
AB  - ISSUES: The lack of consensus about whether low to moderate levels of prenatal
      alcohol exposure are a risk factor for fetal development has generated
      considerable debate about what advice policies and guidelines should provide.
      APPROACH: This paper reviews the evidence from systematic reviews and
      meta-analyses examining the risk from low and moderate levels of prenatal alcohol
      exposure, along with the results of articles published 2009-2010, after the
      reviews. KEY FINDINGS: The reported significant effects from low levels of
      prenatal alcohol exposure are likely due to methodological issues such as
      confounding and/or misclassification of exposure or outcome and there is no
      strong research evidence of fetal effects from low levels of alcohol exposure.
      However, harm is well-documented with heavy exposure and moderate levels of
      exposure, 30-40 g per occasion and no more than 70 g per week, have been
      demonstrated to increase the risk of child behaviour problems. IMPLICATIONS: With
      such a small margin before there is increased risk to the fetus, it would be
      morally and ethically unacceptable for policies and guidelines to condone
      consumption of alcohol during pregnancy. Not all women will follow this advice
      and some women will inadvertently consume alcohol prior to pregnancy awareness
      requiring non-judgmental counselling and the provision of rational advice about
      the likelihood of risk to the fetus. CONCLUSIONS: The policy advice that 'the
      safest choice for pregnant women is to abstain from alcohol during pregnancy'
      should be maintained. However, the abstinence message needs to be presented in a 
      balanced and rational manner to prevent unintended negative consequences.
CI  - (c) 2011 Australasian Professional Society on Alcohol and other Drugs.
FAU - O'Leary, Colleen M
AU  - O'Leary CM
AD  - National Drug Research Institute, Curtin University, Perth, WA 6845, Australia.
      colleen.oleary@curtin.edu.au
FAU - Bower, Carol
AU  - Bower C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110929
PL  - Australia
TA  - Drug Alcohol Rev
JT  - Drug and alcohol review
JID - 9015440
SB  - IM
MH  - Alcohol Drinking/*adverse effects/prevention & control
MH  - Child
MH  - Epidemiologic Research Design
MH  - Female
MH  - Fetus/drug effects
MH  - *Guidelines as Topic
MH  - Health Policy
MH  - Humans
MH  - Meta-Analysis as Topic
MH  - Pregnancy
MH  - Pregnancy Complications/*prevention & control
MH  - Prenatal Exposure Delayed Effects/prevention & control
MH  - Risk Factors
EDAT- 2011/10/01 06:00
MHDA- 2012/06/27 06:00
CRDT- 2011/09/30 06:00
PHST- 2011/09/30 06:00 [entrez]
PHST- 2011/10/01 06:00 [pubmed]
PHST- 2012/06/27 06:00 [medline]
AID - 10.1111/j.1465-3362.2011.00331.x [doi]
PST - ppublish
SO  - Drug Alcohol Rev. 2012 Mar;31(2):170-83. doi: 10.1111/j.1465-3362.2011.00331.x.
      Epub 2011 Sep 29.


PMID- 21954521
OWN - NLM
STAT- MEDLINE
DCOM- 20111025
LR  - 20110929
IS  - 1167-7422 (Print)
IS  - 1167-7422 (Linking)
VI  - 20
IP  - 119
DP  - 2011 Sep
TI  - Medical ethics and social justice.
PG  - 220
LA  - eng
PT  - Journal Article
PL  - France
TA  - Prescrire Int
JT  - Prescrire international
JID - 9439295
MH  - *Ethics, Medical
MH  - Humans
MH  - *Social Justice
EDAT- 2011/10/01 06:00
MHDA- 2011/10/26 06:00
CRDT- 2011/09/30 06:00
PHST- 2011/09/30 06:00 [entrez]
PHST- 2011/10/01 06:00 [pubmed]
PHST- 2011/10/26 06:00 [medline]
PST - ppublish
SO  - Prescrire Int. 2011 Sep;20(119):220.


PMID- 21894131
OWN - NLM
STAT- MEDLINE
DCOM- 20111028
LR  - 20191210
IS  - 0353-5053 (Print)
IS  - 0353-5053 (Linking)
VI  - 23 Suppl 1
DP  - 2011 Sep
TI  - What's in a name? - The Psychiatric Identity Conundrum.
PG  - S178-81
AB  - BACKGROUND: The proper label to describe people receiving care has evoked
      considerable debate and controversy among providers and bio-ethicists.
      Fashionable terms in current use include "patient, client, consumer, customer and
      service user." There is little evidence to show that changes in nomenclature
      actually take patients preferences as to how they would like to be addressed into
      account AIMS: This aim of this study is to survey the views of the people with
      learning disability in inpatient settings to establish the term they prefer. This
      is the first study of its kind looking at the views of people with learning
      disability about how they would like to be addressed and to identify factors
      associated with various preferences. METHOD: Approval was obtained from the local
      clinical governance board. The target population covered a tertiary level
      inpatient service including acute assessment and respite services, forensic
      (male/female and low/medium secure services) and CAMHS LD covering the Coventry, 
      Warwickshire and Birmingham areas (rural and inner city population). Participants
      were provided with an information sheet on the research project. The
      questionnaire was administered by means of a joint interview carried out by the
      authors of the study. Dictionary definitions were analyzed as to the derivation
      and connotations of various terminologies. A questionnaire was developed which
      was tailored for use in PWLD after consultation with Speech & Language Therapists
      and local peer review. Responses were than analyzed to identify factors
      associated with various preferences. RESULTS: Evidence indicates lack of
      universality in preferences for terms and suggests the need for dialogue about
      preferred terms between service providers and recipients. This study shows a
      preference for the term "patient" in all categories that were measured within an 
      LD inpatient setting and very interesting demographic preferences were
      identified. A more differentiated approach may be suggested by taking
      professional background and some demographic characteristics into consideration. 
      A positive therapeutic relationship is a fundamental component of psychiatry and 
      should take into account patients' preferences regarding how they are addressed
      by professionals.
FAU - Thalitaya, Madhusudan Deepak
AU  - Thalitaya MD
AD  - South Essex Partnership University NHS Foundation Trust, Twinwoods Medical
      Centre, Clapham, Bedfordshire, UK. Deepak.thalitaya@sept.ns.uk
FAU - Prasher, Verinder P
AU  - Prasher VP
FAU - Khan, Faheem
AU  - Khan F
FAU - Boer, Harm
AU  - Boer H
LA  - eng
PT  - Journal Article
PL  - Croatia
TA  - Psychiatr Danub
JT  - Psychiatria Danubina
JID - 9424753
SB  - IM
MH  - Adult
MH  - Attitude to Health
MH  - Female
MH  - Humans
MH  - Inpatients/psychology/statistics & numerical data
MH  - Learning Disabilities/*psychology
MH  - Male
MH  - Patient Satisfaction/*statistics & numerical data
MH  - Professional-Patient Relations
MH  - *Self Concept
MH  - *Social Identification
MH  - Surveys and Questionnaires
MH  - *Terminology as Topic
EDAT- 2011/10/01 06:00
MHDA- 2011/10/29 06:00
CRDT- 2011/09/07 06:00
PHST- 2011/09/07 06:00 [entrez]
PHST- 2011/10/01 06:00 [pubmed]
PHST- 2011/10/29 06:00 [medline]
PST - ppublish
SO  - Psychiatr Danub. 2011 Sep;23 Suppl 1:S178-81.


PMID- 23908825
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130805
LR  - 20211021
IS  - 2076-9172 (Print)
IS  - 2076-9172 (Linking)
VI  - 2
IP  - 4
DP  - 2011 Oct
TI  - At the edge of viability: moral and ethical guideline proposals.
PG  - e0067
LID - 10.5041/RMMJ.10067 [doi]
AB  - The paper proposes moral and ethical guidelines for medical treatment at the edge
      of viability. The proposed principles are defended on the grounds of a general
      conceptual framework presented by elucidating the notions of viability, the edge 
      of viability, person, sanctity of human life, dignity, and the slope of dignity
      protection, as well as the distinction between ethics and morality.
FAU - Kasher, Asa
AU  - Kasher A
AD  - Department of Philosophy, Tel Aviv University, Tel Aviv, Israel.
LA  - eng
PT  - Journal Article
DEP - 20111031
PL  - Israel
TA  - Rambam Maimonides Med J
JT  - Rambam Maimonides medical journal
JID - 101538065
PMC - PMC3678804
OTO - NOTNLM
OT  - Edge of viability
OT  - human dignity
OT  - moral and ethical guidelines
OT  - negative compelling reasons
OT  - positive compelling reasons
OT  - principle of moral gradation
EDAT- 2011/10/01 00:00
MHDA- 2011/10/01 00:01
CRDT- 2013/08/03 06:00
PHST- 2013/08/03 06:00 [entrez]
PHST- 2011/10/01 00:00 [pubmed]
PHST- 2011/10/01 00:01 [medline]
AID - 10.5041/RMMJ.10067 [doi]
AID - rmmj-2-4-e0067 [pii]
PST - epublish
SO  - Rambam Maimonides Med J. 2011 Oct 31;2(4):e0067. doi: 10.5041/RMMJ.10067. Print
      2011 Oct.


PMID- 23908824
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130805
LR  - 20211021
IS  - 2076-9172 (Print)
IS  - 2076-9172 (Linking)
VI  - 2
IP  - 4
DP  - 2011 Oct
TI  - Dilemmas in the treatment of premature infants at the borderline of viability.
PG  - e0066
LID - 10.5041/RMMJ.10066 [doi]
AB  - As more reports emerge of improved mortality and morbidity rates in infants born 
      at the edge of viability, there may be need to reassess protocols and
      recommendations that encourage only comfort care for infants who are born at less
      than 24 weeks' gestation. Analysis of those studies that report extremely poor
      survival of these infants reveals that, all too often, the results are measures
      of a self-fulfilling prophesy that reflects a predetermined non-aggressive global
      policy of no resuscitation and minimal investment in intensive care. Furthermore,
      little distinction is made between high- and low-risk infants of the same
      gestational age despite repeated studies that indicate that one can identify
      subpopulations that have as much as a 20-50% increased chance of surviving with
      little if any long-term neurodevelopmental impairment. Thus, the need to reassess
      current policies is discussed.
FAU - Eidelman, Arthur I
AU  - Eidelman AI
AD  - Department of Pediatrics, Shaare Zedek Medical Center, Hebrew University School
      of Medicine, Faculty of Health Sciences, Jerusalem, Israel; Ben Gurion University
      of the Negev, Beer Sheva, Israel.
LA  - eng
PT  - Journal Article
DEP - 20111031
PL  - Israel
TA  - Rambam Maimonides Med J
JT  - Rambam Maimonides medical journal
JID - 101538065
PMC - PMC3678801
OTO - NOTNLM
OT  - Extreme prematurity
OT  - medical ethics
OT  - morbidity
OT  - mortality
OT  - neonatal mortality
OT  - viability
EDAT- 2011/10/01 00:00
MHDA- 2011/10/01 00:01
CRDT- 2013/08/03 06:00
PHST- 2013/08/03 06:00 [entrez]
PHST- 2011/10/01 00:00 [pubmed]
PHST- 2011/10/01 00:01 [medline]
AID - 10.5041/RMMJ.10066 [doi]
AID - rmmj-2-4-e0066 [pii]
PST - epublish
SO  - Rambam Maimonides Med J. 2011 Oct 31;2(4):e0066. doi: 10.5041/RMMJ.10066. Print
      2011 Oct.


PMID- 23472421
OWN - NLM
STAT- MEDLINE
DCOM- 20130409
LR  - 20151119
IS  - 1025-9589 (Print)
IS  - 1025-9589 (Linking)
VI  - 23
IP  - 4
DP  - 2011 Oct-Dec
TI  - Effects of nicotine on an in vitro reconstituted model oral mucosa in terms of
      cytokine production.
PG  - 80-4
AB  - BACKGROUND: The extensive use of tobacco and its associated problematic health
      issues have been a concern to mankind. The World Health Organization (WHO)
      estimates that approximately one-third of the global population aged 15 years or 
      older are smokers and each smoker consumes an average of 15 cigarettes daily. The
      objective of this study was to establish the effect of nicotine on an in vitro
      reconstituted oral mucosa model, the effect of treatment with this compound was
      measured in terms of cytokine production. METHOD: Observational laboratory based 
      study design was used to carry out the experiment. The reconstituted human
      epithelium model used in the study was prepared and supplied by Skin Ethic
      Laboratories, Nice, France. The effect of nicotine on epithelial cytokine
      production was assessed using commercially available assay kits (R&D systems).
      This was done using the enzyme linked immuno-sorbent assay. RESULT: In this study
      there was evidence that after 5 minutes treatment on un-inflamed mucosa with
      nicotine at 10 mm concentration GM-CSF release decreased, and also after 24 hours
      treatment with nicotine at 10mM concentration GM-CSF release increased. TNF-alpha
      increased release of pro-inflammatory cytokines, IL-6, IL-8, and also GM-CSF from
      the model mucosa after 24 hours, but had no effect on the release of IL-1alpha,
      IL-6, IL-8, and GM-CSF after 5 minutes and 24 hours respectively. CONCLUSION: In 
      conclusion at all the concentrations used in this experiment, nicotine had no
      effect on the TNF-alpha stimulated tissue and un-inflamed mucosa and had no
      significant effect on cytokine release including IL-1alpha, IL-6, IL-8, and
      GM-CSF after 5 minutes and 24 hours respectively.
FAU - Sheikh, Muhammad Nauman
AU  - Sheikh MN
AD  - Department of Oral Pathology, Baqai Dental College, Karachi, Pakistan.
      Sheikh_692000@yahoo.com
FAU - Hanif, Sajid
AU  - Hanif S
FAU - Zia, Majid
AU  - Zia M
FAU - Qayyum, Zahur
AU  - Qayyum Z
LA  - eng
PT  - Journal Article
PL  - Pakistan
TA  - J Ayub Med Coll Abbottabad
JT  - Journal of Ayub Medical College, Abbottabad : JAMC
JID - 8910750
RN  - 0 (Cytokines)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 6M3C89ZY6R (Nicotine)
SB  - IM
MH  - Cytokines/*metabolism
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Humans
MH  - In Vitro Techniques
MH  - Mouth Mucosa/*drug effects
MH  - Nicotine/*pharmacology
MH  - Time Factors
MH  - Tumor Necrosis Factor-alpha/pharmacology
EDAT- 2011/10/01 00:00
MHDA- 2013/04/10 06:00
CRDT- 2013/03/12 06:00
PHST- 2013/03/12 06:00 [entrez]
PHST- 2011/10/01 00:00 [pubmed]
PHST- 2013/04/10 06:00 [medline]
PST - ppublish
SO  - J Ayub Med Coll Abbottabad. 2011 Oct-Dec;23(4):80-4.


PMID- 21954410
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1948-5182 (Electronic)
VI  - 3
IP  - 8
DP  - 2011 Aug 27
TI  - Liver transplantation in acute alcoholic hepatitis: Current status and future
      development.
PG  - 215-8
LID - 10.4254/wjh.v3.i8.215 [doi]
AB  - Acute alcoholic hepatitis (AH) is a distinct clinical entity amongst patients
      with chronic alcohol abuse. Patients with severe AH are at risk of dying in about
      20%-25% cases despite specific treatment with corticosteroids and/or
      pentoxifylline. Clearly, a need for an additional more effective treatment option
      is unmet currently. Liver transplantation (LT), a definitive treatment option for
      alcoholic cirrhosis requires 6 mo abstinence. However, this rule cannot be
      applied to patients with AH as these patients are actively drinking prior to
      their presentation. Shortage of donors, ethical issues, and fear of recidivism
      after transplantation with less than 6 mo pre-transplant abstinence are some of
      the reasons behind this rule of 6 mo of abstinence and hesitancy of transplanting
      patients with AH. These issues are debated at length in this manuscript. Further,
      retrospective studies have shown that patients undergoing transplantation for
      alcoholic cirrhosis and having histological changes of AH have been shown to fare
      as well when compared to patients without these histological changes. Recently,
      French workers have reported a case matched prospective study showing encouraging
      data on the usefulness of LT for patients who are non-responders to
      corticosteroid and/or pentoxifylline therapy. Future studies are needed to
      identify patients with severe AH who are going to benefit most with LT. In the
      light of emerging data on the efficacy of LT in improving survival of patients
      with severe acute AH who do not respond to corticosteroids, the time is ripe to
      re-evaluate our policy of LT in patients with AH.
FAU - Singal, Ashwani K
AU  - Singal AK
AD  - Ashwani K Singal, Andrea Duchini, Division of Gastroenterology and Hepatology,
      Mayo Clinic, Rochester, MN 55905-0001, United States.
FAU - Duchini, Andrea
AU  - Duchini A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Hepatol
JT  - World journal of hepatology
JID - 101532469
PMC - PMC3180607
OTO - NOTNLM
OT  - Alcohol abstinence
OT  - Alcoholic hepatitis
OT  - Liver transplantation
OT  - Recidivism
EDAT- 2011/09/29 06:00
MHDA- 2011/09/29 06:01
CRDT- 2011/09/29 06:00
PHST- 2011/11/26 00:00 [received]
PHST- 2011/06/13 00:00 [revised]
PHST- 2011/07/15 00:00 [accepted]
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2011/09/29 06:01 [medline]
AID - 10.4254/wjh.v3.i8.215 [doi]
PST - ppublish
SO  - World J Hepatol. 2011 Aug 27;3(8):215-8. doi: 10.4254/wjh.v3.i8.215.


PMID- 21953382
OWN - NLM
STAT- MEDLINE
DCOM- 20120120
LR  - 20220409
IS  - 1573-2614 (Electronic)
IS  - 1387-1307 (Linking)
VI  - 25
IP  - 4
DP  - 2011 Aug
TI  - Investigation of photoplethysmographic signals and blood oxygen saturation values
      obtained from human splanchnic organs using a fiber optic sensor.
PG  - 245-55
LID - 10.1007/s10877-011-9302-4 [doi]
AB  - OBJECTIVE: A reliable, continuous method of monitoring splanchnic organ oxygen
      saturation could allow for the early detection of malperfusion, and may prevent
      the onset of multiple organ failure. Current monitoring techniques have not been 
      widely accepted in critical care monitoring. As a preliminary to developing a
      continuous indwelling device, this study evaluates a new handheld fiber optic
      photoplethysmographic (PPG) sensor for estimating the blood oxygen saturation
      (SpO(2)) of splanchnic organs during surgery. METHODS: A fiber optic splanchnic
      PPG sensor, instrumentation system and virtual instrument were developed to
      facilitate PPG and SpO(2) measurement from splanchnic organs. Following Local
      Research Ethics Committee approval, the sensor was evaluated on seventeen ASA 1
      and 2 patients undergoing open laparotomy. PPG signals were obtained from the
      large bowel, small bowel, liver and stomach. Simultaneous PPG signals from the
      finger were also obtained using an identical fiber optic sensor. RESULTS: Good
      quality PPG signals with high signal-to-noise (SNR) ratios were obtained from all
      splanchnic sites under investigation. Analysis of the ac and dc amplitudes of the
      red and infrared PPG signals showed there to be a statistically significant
      difference between PPG signals obtained from splanchnic organs with those
      obtained from the finger (using fiber optic sensors). Estimated SpO(2) values
      from the splanchnic organs show good agreement with those obtained from the
      finger using both a fiber optic sensor and a commercial device. Furthermore, the 
      results of a Bland and Altman analysis indicate that fiber optic splanchnic pulse
      oximetry, particularly of the bowel, may provide a suitable method for monitoring
      splanchnic organ perfusion. CONCLUSION: The evaluation of a new fiber optic
      sensor on anaesthetized patients undergoing laparotomy demonstrated that good
      quality PPG signals and SpO(2) estimates can be obtained from splanchnic organs. 
      Such a sensor may provide a useful tool for the intraoperative assessment of
      splanchnic perfusion.
FAU - Hickey, Michelle
AU  - Hickey M
AD  - School of Engineering and Mathematical Sciences, City University London,
      Northampton Square, London, EC1V 0HB, UK. m.hickey@city.ac.uk
FAU - Samuels, Neal
AU  - Samuels N
FAU - Randive, Nilesh
AU  - Randive N
FAU - Langford, R M
AU  - Langford RM
FAU - Kyriacou, P A
AU  - Kyriacou PA
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110928
PL  - Netherlands
TA  - J Clin Monit Comput
JT  - Journal of clinical monitoring and computing
JID - 9806357
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adult
MH  - Blood Gas Monitoring, Transcutaneous/instrumentation/methods
MH  - Female
MH  - Fingers
MH  - Humans
MH  - Infrared Rays
MH  - Laparotomy
MH  - Male
MH  - Middle Aged
MH  - Monitoring, Intraoperative/instrumentation/methods
MH  - Optical Fibers
MH  - Oximetry/*instrumentation/methods
MH  - Oxygen/*blood
MH  - Photoplethysmography/*instrumentation/methods
MH  - *Splanchnic Circulation
EDAT- 2011/09/29 06:00
MHDA- 2012/01/21 06:00
CRDT- 2011/09/29 06:00
PHST- 2010/12/16 00:00 [received]
PHST- 2011/09/08 00:00 [accepted]
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/01/21 06:00 [medline]
AID - 10.1007/s10877-011-9302-4 [doi]
PST - ppublish
SO  - J Clin Monit Comput. 2011 Aug;25(4):245-55. doi: 10.1007/s10877-011-9302-4. Epub 
      2011 Sep 28.


PMID- 21952594
OWN - NLM
STAT- MEDLINE
DCOM- 20120116
LR  - 20170721
IS  - 1827-1596 (Electronic)
IS  - 0375-9393 (Linking)
VI  - 77
IP  - 10
DP  - 2011 Oct
TI  - Relationship between mixed venous oxygen saturation and regional cerebral
      oxygenation in awake, spontaneously breathing cardiac surgery patients.
PG  - 952-8
AB  - BACKGROUND: In search of a non-invasive method for estimation of the oxygen
      balance this prospective study evaluates the relationship between regional
      cerebral oxygenation (rScO2) and mixed venous oxygen saturation in awake,
      spontaneously breathing patients after cardiac surgery. METHODS: After approval
      by the local ethical committee and written informed consent, 26 consecutive
      patients after cardiac surgery with cardiopulmonary bypass were enrolled. On
      intensive care unit (ICU), several hours after extubation, patients were
      connected to the INVOS 5100 cerebral monitor. Blood samples for determination of 
      mixed venous oxygen saturation (SvO2) and central venous oxygen saturation
      (ScvO2) were drawn successively and rScO2 was documented. Patients were studied
      twice, breathing room air for the first measurement cycle, and breathing 4L/min
      supplemental oxygen by face mask, achieving a transcutaneous oxygen saturation
      above 98%, for a second measurement. RESULTS: Hemodynamic variables, hemoglobin
      and arterial carbon dioxide tension (PaCO2) remained stable between the two
      measurement cycles. Without oxygen, SvO2 and rScO2 showed a bias of -2.0%, limits
      of agreement (LOA) of -15.0 to 10.9% and a percentage error (PE) of 20.3%. SvO2
      and ScvO2 showed a bias of -3.9%, LOA of -13.9 to 6.2% and PE 15.7%. With oxygen,
      the bias between SvO2 and rScO2 was -2.5%, LOA -14.2 to 9.2%, PE 17.2%. Between
      SvO2 and ScvO2 the bias was -4.1%, LOA -10.2 to 2.1%, PE 9.0%. CONCLUSION: The
      rScO2 measured by near infrared spectroscopy was sufficiently representing mixed 
      venous oxygen saturation in awake, hemodynamically stable, spontaneously
      breathing patients after cardiac surgery. The agreement was comparable to the
      agreement between SvO2 and ScvO2 with smaller differences in the lower ranges of 
      SvO2.
FAU - Schon, J
AU  - Schon J
AD  - Department of Anesthesiology, University of Luebeck, Germany.
FAU - Heringlake, M
AU  - Heringlake M
FAU - Berger, K-U
AU  - Berger KU
FAU - Volker Groesdonk, H
AU  - Volker Groesdonk H
FAU - Sedemund-Adib, B
AU  - Sedemund-Adib B
FAU - Paarmann, H
AU  - Paarmann H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Italy
TA  - Minerva Anestesiol
JT  - Minerva anestesiologica
JID - 0375272
RN  - 0 (Hemoglobins)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Blood Gas Analysis
MH  - Brain Chemistry/physiology
MH  - *Cardiac Surgical Procedures
MH  - Cardiopulmonary Bypass
MH  - Female
MH  - Hemodynamics/physiology
MH  - Hemoglobins/metabolism
MH  - Humans
MH  - Hypoxia/therapy
MH  - Male
MH  - Monitoring, Intraoperative
MH  - Oxygen/*blood
MH  - Oxygen Consumption/*physiology
MH  - Perioperative Care
MH  - Respiratory Mechanics/physiology
EDAT- 2011/09/29 06:00
MHDA- 2012/01/17 06:00
CRDT- 2011/09/29 06:00
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/01/17 06:00 [medline]
AID - R02116099 [pii]
PST - ppublish
SO  - Minerva Anestesiol. 2011 Oct;77(10):952-8.


PMID- 21952502
OWN - NLM
STAT- MEDLINE
DCOM- 20120829
LR  - 20161125
IS  - 1423-0003 (Electronic)
IS  - 0304-324X (Linking)
VI  - 58
IP  - 3
DP  - 2012
TI  - The eldercare factory.
PG  - 282-8
LID - 10.1159/000329483 [doi]
AB  - Rapid advances in service robotics together with dramatic shifts in population
      demographics have led to the notion that technology may be the answer to our
      eldercare problems. Robots are being developed for feeding, washing, lifting,
      carrying and mobilising the elderly as well as monitoring their health. They are 
      also being proposed as a substitute for companionship. While these technologies
      could accrue major benefits for society and empower the elderly, we must balance 
      their use with the ethical costs. These include a potential reduction in human
      contact, increased feeling of objectification and loss of control, loss of
      privacy and personal freedom as well as deception and infantilisation. With
      appropriate guidelines in place before the introduction of robots en masse into
      the care system, robots could improve the lives of the elderly, reducing their
      dependence and creating more opportunities for social interaction. Without
      forethought, the elderly may find themselves in a barren world of machines, a
      world of automated care: a factory for the elderly.
CI  - Copyright (c) 2011 S. Karger AG, Basel.
FAU - Sharkey, Noel
AU  - Sharkey N
AD  - Department of Computer Science, University of Sheffield, Sheffield, UK.
      N.Sharkey@dcs.shef.ac.uk
FAU - Sharkey, Amanda
AU  - Sharkey A
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110924
PL  - Switzerland
TA  - Gerontology
JT  - Gerontology
JID - 7601655
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/ethics/physiology
MH  - Dementia/diagnosis/epidemiology/therapy
MH  - Female
MH  - Forecasting
MH  - Frail Elderly
MH  - Geriatric Assessment/methods
MH  - Geriatrics/ethics/*methods
MH  - Health Services for the Aged/ethics/*organization & administration/trends
MH  - Humans
MH  - Life Expectancy
MH  - Male
MH  - Needs Assessment
MH  - Nursing Homes/ethics/*organization & administration/trends
MH  - *Quality of Life
MH  - Robotics/ethics/*methods
MH  - United Kingdom
EDAT- 2011/09/29 06:00
MHDA- 2012/08/30 06:00
CRDT- 2011/09/29 06:00
PHST- 2011/01/27 00:00 [received]
PHST- 2011/05/18 00:00 [accepted]
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/08/30 06:00 [medline]
AID - 000329483 [pii]
AID - 10.1159/000329483 [doi]
PST - ppublish
SO  - Gerontology. 2012;58(3):282-8. doi: 10.1159/000329483. Epub 2011 Sep 24.


PMID- 21952392
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20151119
IS  - 1175-8716 (Electronic)
IS  - 0028-8446 (Linking)
VI  - 124
IP  - 1340
DP  - 2011 Aug 12
TI  - Chiropractor code of ethics: the importance of setting a good example.
PG  - 94-5
FAU - Gilbey, Andrew
AU  - Gilbey A
FAU - Perezgonzalez, Jose
AU  - Perezgonzalez J
LA  - eng
PT  - Letter
DEP - 20110812
PL  - New Zealand
TA  - N Z Med J
JT  - The New Zealand medical journal
JID - 0401067
SB  - IM
CIN - N Z Med J. 2011 Aug 26;124(1341):75. PMID: 21959642
MH  - Chiropractic/*ethics/standards
MH  - *Codes of Ethics
MH  - *Ethics, Professional
MH  - Female
MH  - Humans
MH  - Male
MH  - New Zealand
MH  - Practice Patterns, Physicians'/ethics/standards
MH  - Quality Improvement
EDAT- 2011/09/29 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/09/29 06:00
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PST - epublish
SO  - N Z Med J. 2011 Aug 12;124(1340):94-5.


PMID- 21952173
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20211203
IS  - 1538-2990 (Electronic)
IS  - 0002-9629 (Linking)
VI  - 342
IP  - 4
DP  - 2011 Oct
TI  - From laboratory to bedside: ethical, legal and social issues in translational
      research.
PG  - 265-6
LID - 10.1097/MAJ.0b013e318227deb1 [doi]
FAU - Sade, Robert M
AU  - Sade RM
AD  - Department of Surgery and the Institute of Human Values in Health Care, Medical
      University of South Carolina, Charleston, South Carolina 29425-2950, USA.
      sader@musc.edu
LA  - eng
GR  - UL1 RR029882/RR/NCRR NIH HHS/United States
GR  - UL1RR029882/RR/NCRR NIH HHS/United States
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United States
TA  - Am J Med Sci
JT  - The American journal of the medical sciences
JID - 0370506
SB  - IM
MH  - Animal Experimentation/ethics/history/legislation & jurisprudence
MH  - Bioethical Issues
MH  - History, 18th Century
MH  - History, 19th Century
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Informed Consent/ethics/legislation & jurisprudence
MH  - Social Environment
MH  - Translational Research, Biomedical/*ethics/history/*legislation & jurisprudence
PMC - PMC4517669
MID - NIHMS710031
EDAT- 2011/09/29 06:00
MHDA- 2011/11/09 06:00
CRDT- 2011/09/29 06:00
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - 10.1097/MAJ.0b013e318227deb1 [doi]
AID - S0002-9629(15)31152-6 [pii]
PST - ppublish
SO  - Am J Med Sci. 2011 Oct;342(4):265-6. doi: 10.1097/MAJ.0b013e318227deb1.


PMID- 21952159
OWN - NLM
STAT- MEDLINE
DCOM- 20120123
LR  - 20170123
IS  - 2384-8553 (Electronic)
IS  - 0021-2571 (Linking)
VI  - 47
IP  - 3
DP  - 2011
TI  - Proposal for a new detection method of substance abuse risk in Croatian
      adolescents.
PG  - 316-20
LID - 10.4415/ANN_11_03_13 [doi]
AB  - One of the most important factors of successful substance abuse treatment is the 
      early start of the same treatment. Recent selection method for identification of 
      Croatian adolescents in the substance abuse risk that has been using drug tests
      from urine samples, has been simple and exact on the one hand, but on the other, 
      has been very rare and usually guided by the pressure of parents or the court.
      Besides, such method presented the source of legal and ethical questions. So, the
      proposal of application of standardized psychological tests during systematic
      medical exams of Croatian adolescents at the age range of 15-22 years could help 
      with the early detection of those adolescents who were in the substance abuse
      risk or already had the developed addiction problem.
FAU - Tatalovic Vorkapic, Sanja
AU  - Tatalovic Vorkapic S
AD  - University of Rijeka, Croatia. sanjatv@ufri.hr
FAU - Dadic-Hero, Elizabeta
AU  - Dadic-Hero E
FAU - Ruzic, Klementina
AU  - Ruzic K
FAU - Roncevic, Dobrica
AU  - Roncevic D
FAU - Knez, Rajna
AU  - Knez R
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Ann Ist Super Sanita
JT  - Annali dell'Istituto superiore di sanita
JID - 7502520
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Croatia/epidemiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Parents
MH  - Psychological Tests
MH  - Risk Assessment/*methods
MH  - Risk Factors
MH  - Substance-Related Disorders/diagnosis/*epidemiology
MH  - Young Adult
EDAT- 2011/09/29 06:00
MHDA- 2012/01/24 06:00
CRDT- 2011/09/29 06:00
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/01/24 06:00 [medline]
AID - 10.4415/ANN_11_03_13 [doi]
PST - ppublish
SO  - Ann Ist Super Sanita. 2011;47(3):316-20. doi: 10.4415/ANN_11_03_13.


PMID- 21952152
OWN - NLM
STAT- MEDLINE
DCOM- 20120123
LR  - 20170123
IS  - 2384-8553 (Electronic)
IS  - 0021-2571 (Linking)
VI  - 47
IP  - 3
DP  - 2011
TI  - Ethical issues in neonatal intensive care.
PG  - 273-7
LID - 10.4415/ANN_11_03_06 [doi]
AB  - Recent progress in neonatal care have significantly improved the prognosis and
      chances of survival of critically ill or extremely preterm neonates and have
      modified the limits of viability. However, in some circumstances, when the
      child's death can only be briefly postponed at the price of severe suffering, or 
      when survival is associated with severe disabilities and an intolerable life for 
      the child and his/her parents, the application of the full armamentarium of
      modern neonatal intensive care may not be appropriate. In such circumstances the 
      limitation of intensive treatments (withholding or withdrawing) and shift towards
      palliative care, can represent a more humane and reasonable alternative. This
      article examines and discusses the ethical principles underlying such difficult
      decisions, the most frequent situations in which these decisions may be
      considered, the role of parents in the decisional process, and the opinions and
      behaviours of neonatologists of several European neonatal intensive units as
      reported by the EURONIC study.
FAU - Orzalesi, Marcello M
AU  - Orzalesi MM
AD  - Fondazione Maruzza Lefebvre D'Ovidio Onlus, Rome, Italy. m.orzalesi@maruzza.org
FAU - Cuttini, Marina
AU  - Cuttini M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - Ann Ist Super Sanita
JT  - Annali dell'Istituto superiore di sanita
JID - 7502520
SB  - IM
MH  - Adult
MH  - Attitude of Health Personnel
MH  - Child
MH  - Europe
MH  - Euthanasia, Passive/ethics
MH  - Humans
MH  - Infant, Newborn
MH  - Intensive Care, Neonatal/*ethics
MH  - Italy
MH  - Morals
MH  - Parents
MH  - Withholding Treatment/ethics
EDAT- 2011/09/29 06:00
MHDA- 2012/01/24 06:00
CRDT- 2011/09/29 06:00
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/01/24 06:00 [medline]
AID - 10.4415/ANN_11_03_06 [doi]
PST - ppublish
SO  - Ann Ist Super Sanita. 2011;47(3):273-7. doi: 10.4415/ANN_11_03_06.


PMID- 21952151
OWN - NLM
STAT- MEDLINE
DCOM- 20120123
LR  - 20170123
IS  - 2384-8553 (Electronic)
IS  - 0021-2571 (Linking)
VI  - 47
IP  - 3
DP  - 2011
TI  - Prevention, communication and equity in environmental epidemiology: ethical
      issues.
PG  - 266-72
LID - 10.4415/ANN_11_03_05 [doi]
AB  - In environmental epidemiology research, decisions about when and how to intervene
      requires adequate ethical reflection. In fact, different kinds of issues may
      arise about: research methods and knowledge production; management of the results
      in terms of their overall assessments or for the implementation of preventive
      actions; reclamation intervention. In this contribution we propose to consider
      three topics we regard as crucial to this ethical debate: the reporting of
      conclusive research data; the correct application of the precautionary principle;
      and the environmental equity issues.
FAU - Pagliarani, Giovanna
AU  - Pagliarani G
AD  - Dipartimento di Filosofia, Sapienza Universita di Roma, Italy.
      giordana_pagliarani@hotmail.it
FAU - Botti, Caterina
AU  - Botti C
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - Ann Ist Super Sanita
JT  - Annali dell'Istituto superiore di sanita
JID - 7502520
SB  - IM
MH  - *Communication
MH  - Environment
MH  - Environmental Health/*ethics/legislation & jurisprudence
MH  - Epidemiology/*ethics/legislation & jurisprudence
MH  - Humans
MH  - Italy
MH  - Preventive Medicine/*ethics/legislation & jurisprudence
MH  - Risk
MH  - Risk Assessment
EDAT- 2011/09/29 06:00
MHDA- 2012/01/24 06:00
CRDT- 2011/09/29 06:00
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/01/24 06:00 [medline]
AID - 10.4415/ANN_11_03_05 [doi]
PST - ppublish
SO  - Ann Ist Super Sanita. 2011;47(3):266-72. doi: 10.4415/ANN_11_03_05.


PMID- 21952148
OWN - NLM
STAT- MEDLINE
DCOM- 20120123
LR  - 20110928
IS  - 2384-8553 (Electronic)
IS  - 0021-2571 (Linking)
VI  - 47
IP  - 3
DP  - 2011
TI  - Ethical issues in videorecording patients lacking capacity to consent.
PG  - 247-52
LID - 10.4415/ANN_11_03_02 [doi]
AB  - Videorecording of patients requires the utmost respect for the privacy and
      confidentiality of the patients. Consent should be requested from patients for
      all videorecording. When a mental disability or mental or physical illness
      prevents patients from giving their permission, agreement to recording from a
      legal representative or from a close relative or carer are necessary. Three
      documents on this subject issued in the United Kingdom, the United State of
      America and Italy are briefly summarized and discussed. The problem of consent
      for videorecording is addressed particularly in reference to persons incapable of
      making decisions on their own, such as persons in vegetative state. The general
      ethical framework is outlined and a few practical proposals are given.
FAU - Petrini, Carlo
AU  - Petrini C
AD  - Unita di Bioetica, Presidenza, Istituto Superiore di Sanita, Rome, Italy.
      carlo.petrini@iss.it
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - Ann Ist Super Sanita
JT  - Annali dell'Istituto superiore di sanita
JID - 7502520
SB  - IM
MH  - American Medical Association
MH  - Computer Security/legislation & jurisprudence
MH  - Confidentiality
MH  - Guidelines as Topic
MH  - Humans
MH  - Information Dissemination
MH  - Informed Consent/*ethics
MH  - Italy
MH  - United States
MH  - Video Recording/*ethics
EDAT- 2011/09/29 06:00
MHDA- 2012/01/24 06:00
CRDT- 2011/09/29 06:00
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/01/24 06:00 [medline]
AID - 10.4415/ANN_11_03_02 [doi]
PST - ppublish
SO  - Ann Ist Super Sanita. 2011;47(3):247-52. doi: 10.4415/ANN_11_03_02.


PMID- 21952054
OWN - NLM
STAT- MEDLINE
DCOM- 20111229
LR  - 20111027
IS  - 1938-808X (Electronic)
IS  - 1040-2446 (Linking)
VI  - 86
IP  - 11
DP  - 2011 Nov
TI  - Going beyond Kirkpatrick in evaluating a clinician scientist program: it's not
      "if it works" but "how it works".
PG  - 1389-96
LID - 10.1097/ACM.0b013e31823053f3 [doi]
AB  - PURPOSE: To explore how the Canadian Child Health Clinician Scientist Program
      (CCHCSP) works to achieve prearticulated and emergent outcomes. METHOD: In 2009, 
      after gaining ethical approval from the Hospital for Sick Children, the authors
      examined quantitative data (e.g., participation in curriculum elements) to ensure
      sufficient exposure by trainees to the program and quantitative outputs (e.g.,
      publications) to measure achievement of CCHCSP goals. They identified emergent
      outcomes through grouping and analyzing qualitative data generated through
      interviews with program graduates. Then, to explore possible theoretical
      explanations for the emergent findings, the authors conducted a literature
      review. RESULTS: Graduates participated in high rates in each component of the
      CCHCSP and produced publications, presented research, and received funding.
      Interview data revealed an unexpected outcome: that the CCHCSP helped graduates
      to form new professional identities. These data, along with theoretical
      assumptions from Ibarra's theory on professional identity change, informed a new 
      theory or model for the CCHCSP. CONCLUSIONS: Early investment in building a
      program's logic model is invaluable for understanding program goals and for
      guiding program planning and development. Both employing a strategy that captures
      emergent program outcomes and investigating (e.g., through a literature search)
      why and how the program actually works to arrive at these outcomes informs the
      development and evaluation of future program offerings and may, as in the case of
      the CCHCSP, offer a new program model or theory.
FAU - Parker, Kathryn
AU  - Parker K
AD  - Holland Bloorview Kids Rehabilitation Hospital, and Department of Paediatrics,
      Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
      kparker@hollandbloorview.ca
FAU - Burrows, Gwen
AU  - Burrows G
FAU - Nash, Heather
AU  - Nash H
FAU - Rosenblum, Norman D
AU  - Rosenblum ND
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Acad Med
JT  - Academic medicine : journal of the Association of American Medical Colleges
JID - 8904605
SB  - IM
MH  - Biomedical Research/education/*organization & administration
MH  - Canada
MH  - Child
MH  - *Child Welfare
MH  - Clinical Competence
MH  - *Curriculum
MH  - Education, Medical, Graduate/organization & administration
MH  - Hospitals, Pediatric/organization & administration
MH  - Humans
MH  - Interprofessional Relations
MH  - Pediatrics/education/*organization & administration
MH  - Program Development
MH  - Program Evaluation
EDAT- 2011/09/29 06:00
MHDA- 2011/12/30 06:00
CRDT- 2011/09/29 06:00
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2011/12/30 06:00 [medline]
AID - 10.1097/ACM.0b013e31823053f3 [doi]
PST - ppublish
SO  - Acad Med. 2011 Nov;86(11):1389-96. doi: 10.1097/ACM.0b013e31823053f3.


PMID- 21951935
OWN - NLM
STAT- MEDLINE
DCOM- 20120131
LR  - 20181201
IS  - 1365-2753 (Electronic)
IS  - 1356-1294 (Linking)
VI  - 17
IP  - 5
DP  - 2011 Oct
TI  - Epistemology and ethics of evidence-based medicine: a response to comments.
PG  - 1002-3; discussion 1004-5
LID - 10.1111/j.1365-2753.2011.01736.x [doi]
FAU - Sestini, Piersante
AU  - Sestini P
AD  - Department of Clinical Medicine and Immunological Sciences, Section of
      Respiratory Diseases, University of Siena, Siena, Italy. sestini@unisi.it
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - England
TA  - J Eval Clin Pract
JT  - Journal of evaluation in clinical practice
JID - 9609066
SB  - IM
CON - J Eval Clin Pract. 2010 Apr;16(2):306-9. PMID: 20367853
MH  - Evidence-Based Medicine/*ethics
MH  - Humans
MH  - *Knowledge
MH  - *Philosophy, Medical
EDAT- 2011/09/29 06:00
MHDA- 2012/02/01 06:00
CRDT- 2011/09/29 06:00
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/02/01 06:00 [medline]
AID - 10.1111/j.1365-2753.2011.01736.x [doi]
PST - ppublish
SO  - J Eval Clin Pract. 2011 Oct;17(5):1002-3; discussion 1004-5. doi:
      10.1111/j.1365-2753.2011.01736.x.


PMID- 21951929
OWN - NLM
STAT- MEDLINE
DCOM- 20120131
LR  - 20130708
IS  - 1365-2753 (Electronic)
IS  - 1356-1294 (Linking)
VI  - 17
IP  - 5
DP  - 2011 Oct
TI  - Criticizing the data: some concerns about empirical approaches to ethics.
PG  - 970-5
LID - 10.1111/j.1365-2753.2011.01750.x [doi]
AB  - There are strong arguments in favour of the need for more 'empirically informed
      philosophy'. Using papers in the current issue of JECP as case studies, I raise
      fundamental and unresolved methodological questions about the proper relationship
      between philosophy and empirical research, in particular concerning the
      relationship between 'data' in empirical research and the 'responses' people give
      in to questions in the process of philosophical dialogue. There are tensions
      between the role of data in empirical research and the critical stance required
      for philosophy that need to be addressed, if empirically informed philosophy is
      to make a serious and substantial contribution to our thinking about the matters 
      of great import it addresses.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Loughlin, Michael
AU  - Loughlin M
AD  - Department of Interdisciplinary Studies, MMU Cheshire, Crewe, UK.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Eval Clin Pract
JT  - Journal of evaluation in clinical practice
JID - 9609066
SB  - IM
CIN - J Eval Clin Pract. 2013 Jun;19(3):553-8. PMID: 23692244
MH  - *Empirical Research
MH  - *Ethics, Clinical
MH  - Humans
MH  - Philosophy, Medical
EDAT- 2011/09/29 06:00
MHDA- 2012/02/01 06:00
CRDT- 2011/09/29 06:00
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/02/01 06:00 [medline]
AID - 10.1111/j.1365-2753.2011.01750.x [doi]
PST - ppublish
SO  - J Eval Clin Pract. 2011 Oct;17(5):970-5. doi: 10.1111/j.1365-2753.2011.01750.x.


PMID- 21951928
OWN - NLM
STAT- MEDLINE
DCOM- 20120131
LR  - 20181201
IS  - 1365-2753 (Electronic)
IS  - 1356-1294 (Linking)
VI  - 17
IP  - 5
DP  - 2011 Oct
TI  - Opportunities and risks in gauging practitioners' ethical commitments--commentary
      on Little et al.
PG  - 954-6
LID - 10.1111/j.1365-2753.2011.01742.x [doi]
FAU - Calder, Gideon
AU  - Calder G
AD  - University of Wales, Newport, UK.
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - England
TA  - J Eval Clin Pract
JT  - Journal of evaluation in clinical practice
JID - 9609066
SB  - IM
CON - J Eval Clin Pract. 2011 Oct;17(5):948-53. PMID: 21815972
MH  - *Ethics, Clinical
MH  - Humans
MH  - *Virtues
EDAT- 2011/09/29 06:00
MHDA- 2012/02/01 06:00
CRDT- 2011/09/29 06:00
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/02/01 06:00 [medline]
AID - 10.1111/j.1365-2753.2011.01742.x [doi]
PST - ppublish
SO  - J Eval Clin Pract. 2011 Oct;17(5):954-6. doi: 10.1111/j.1365-2753.2011.01742.x.


PMID- 21951635
OWN - NLM
STAT- MEDLINE
DCOM- 20120517
LR  - 20120116
IS  - 1600-6143 (Electronic)
IS  - 1600-6135 (Linking)
VI  - 12
IP  - 1
DP  - 2012 Jan
TI  - The ethical complexities of online organ solicitation via donor-patient websites:
      avoiding the "beauty contest".
PG  - 43-7
LID - 10.1111/j.1600-6143.2011.03765.x [doi]
AB  - The proliferation of the Internet has spurred the creation of websites dedicated 
      to facilitating living directed organ donations. We argue that such sites
      potentially devolve into "beauty contests" where patients in need are evaluated
      on the basis of their personal appearance and biography-variables which should
      have no relevance to organ allocation. Altruism should be the guiding motivation 
      for all donations, and when it does, there is no place for a beauty contest. The 
      power of the Internet is optimally used when it facilitates Good Samaritan
      donations-donations to any stranger, rather than handpicked ones. Social
      networking sites which aim to match potential donors and patients should mask
      personal identifying information, allowing the ethical principles of altruism and
      justice to guide organ allocation.
CI  - (c)Copyright 2011 The American Society of Transplantation and the American
      Society of Transplant Surgeons.
FAU - Neidich, E M
AU  - Neidich EM
AD  - University of California, San Francisco School of Medicine, San Francisco, CA,
      USA.
FAU - Neidich, A B
AU  - Neidich AB
FAU - Cooper, J T
AU  - Cooper JT
FAU - Bramstedt, K A
AU  - Bramstedt KA
LA  - eng
GR  - 234-2005-37011C/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20110922
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
SB  - IM
MH  - Altruism
MH  - Humans
MH  - *Internet
MH  - *Social Networking
MH  - Tissue and Organ Procurement/*ethics
EDAT- 2011/09/29 06:00
MHDA- 2012/05/18 06:00
CRDT- 2011/09/29 06:00
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/05/18 06:00 [medline]
AID - 10.1111/j.1600-6143.2011.03765.x [doi]
PST - ppublish
SO  - Am J Transplant. 2012 Jan;12(1):43-7. doi: 10.1111/j.1600-6143.2011.03765.x. Epub
      2011 Sep 22.


PMID- 21951456
OWN - NLM
STAT- MEDLINE
DCOM- 20120201
LR  - 20110928
IS  - 1440-1754 (Electronic)
IS  - 1034-4810 (Linking)
VI  - 47
IP  - 9
DP  - 2011 Sep
TI  - Ethical issues in genetics.
PG  - 668-71
LID - 10.1111/j.1440-1754.2011.02168.x [doi]
AB  - Genetic disorders are caused by abnormalities in genes and chromosomes and for
      the most part have implications for family members, affecting such matters as
      confidentiality and disclosure to third parties. Genetic testing can be not only 
      diagnostic but also predictive, raising issues of the need for pre-test
      counselling, protection of children from unwanted testing, and most importantly, 
      the imprecision of interpretation of future risk. The rise in availability of
      direct-to-consumer testing is a fresh cause for concern, as are the new
      possibilities in reproductive medicine. New technologies and the falling cost of 
      whole genome sequencing ensure that ethics will be a prominent concern for
      clinical genetics.
CI  - (c) 2011 The Author. Journal of Paediatrics and Child Health (c) 2011 Paediatrics
      and Child Health Division (Royal Australasian College of Physicians).
FAU - Wilcken, Bridget
AU  - Wilcken B
AD  - Biochemical Genetics and Newborn Screening Departments, The Children's Hospital
      at Westmead, Sydney, New South Wales, Australia. bridgetw@chw.edu.au
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Paediatr Child Health
JT  - Journal of paediatrics and child health
JID - 9005421
SB  - IM
MH  - Confidentiality/ethics
MH  - Female
MH  - Genetic Services/*ethics
MH  - Genetic Techniques/*ethics
MH  - Genetics, Medical/*ethics
MH  - Health Services Accessibility/ethics
MH  - Humans
MH  - Infant, Newborn
MH  - Neonatal Screening/ethics
MH  - Pregnancy
MH  - Prenatal Diagnosis/ethics
EDAT- 2011/09/29 06:00
MHDA- 2012/02/02 06:00
CRDT- 2011/09/29 06:00
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/02/02 06:00 [medline]
AID - 10.1111/j.1440-1754.2011.02168.x [doi]
PST - ppublish
SO  - J Paediatr Child Health. 2011 Sep;47(9):668-71. doi:
      10.1111/j.1440-1754.2011.02168.x.


PMID- 21951455
OWN - NLM
STAT- MEDLINE
DCOM- 20120201
LR  - 20110928
IS  - 1440-1754 (Electronic)
IS  - 1034-4810 (Linking)
VI  - 47
IP  - 9
DP  - 2011 Sep
TI  - The ethics of paediatric research.
PG  - 664-7
LID - 10.1111/j.1440-1754.2011.02166.x [doi]
AB  - Paediatric research is essential for improving health outcomes of children.
      Waiting for adult studies before conducting paediatric studies will prolong the
      denial of effective treatment for children. If we rely on information from adult 
      studies rather than conducting studies with children, we risk causing harm to
      children. In this paper, we identify and examine ethical issues unique to
      conducting research with children. These include the function and the value of a 
      child's assent and the criteria that should guide a proxy in making decisions
      about a child's involvement in research, offering payment to children for
      research participation and acceptable levels of risk for paediatric research.
      Justice demands that children not be denied the benefits of research, and it is
      the role of the paediatric medical community to advocate not only for more
      research for children but also to ensure that the research conducted is of the
      highest quality.
CI  - (c) 2011 The Authors. Journal of Paediatrics and Child Health (c) 2011
      Paediatrics and Child Health Division (Royal Australasian College of Physicians).
FAU - Spriggs, Merle
AU  - Spriggs M
AD  - Children's Bioethics Centre, Murdoch Children's Research Institute, Centre for
      Health and Society, University of Melbourne, Parkville, New South Wales,
      Australia.
FAU - Caldwell, Patrina H Y
AU  - Caldwell PH
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Paediatr Child Health
JT  - Journal of paediatrics and child health
JID - 9005421
SB  - IM
MH  - Child
MH  - Child Welfare/*ethics
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Informed Consent/ethics
MH  - Minors
MH  - Pediatrics/*ethics
MH  - Remuneration
MH  - Risk Assessment
EDAT- 2011/09/29 06:00
MHDA- 2012/02/02 06:00
CRDT- 2011/09/29 06:00
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/02/02 06:00 [medline]
AID - 10.1111/j.1440-1754.2011.02166.x [doi]
PST - ppublish
SO  - J Paediatr Child Health. 2011 Sep;47(9):664-7. doi:
      10.1111/j.1440-1754.2011.02166.x.


PMID- 21951454
OWN - NLM
STAT- MEDLINE
DCOM- 20120201
LR  - 20110928
IS  - 1440-1754 (Electronic)
IS  - 1034-4810 (Linking)
VI  - 47
IP  - 9
DP  - 2011 Sep
TI  - Ethical and legal aspects of management for disorders of sex development.
PG  - 661-3
LID - 10.1111/j.1440-1754.2011.02164.x [doi]
AB  - Intense controversy surrounds the management of disorders of sex development,
      particularly in relation to the validity of parental consent for genital surgery 
      and the removal of gonadal tissue carried out during infancy or childhood. Past
      practices have been heavily criticised on ethical grounds by patient advocacy
      organisations, who have demanded a moratorium on these kinds of operations unless
      authorised by a court. Some doctors and hospital administrators have been
      influenced by the controversy and have referred cases to the Family Court of
      Australia, where a series of judgements have now established legal precedents
      that apply across Australia, restricting the circumstances in which parents can
      give consent for surgery. An alternative approach is to use a hospital-based
      Clinical Ethics Response Group and, if necessary, Clinical Ethics Committee,
      which has lay and legal representatives as well as health professionals, as a
      semi-independent committee of review. Finding a solution that protects the human 
      rights and best interests of children is an ongoing challenge.
CI  - (c) 2011 The Authors. Journal of Paediatrics and Child Health (c) 2011
      Paediatrics and Child Health Division (Royal Australasian College of Physicians).
FAU - Warne, Garry L
AU  - Warne GL
AD  - Department of Endocrinology and Diabetes, Royal Children's Hospital Melbourne,
      Melbourne, Victoria, Australia. garry.warne@rch.org.au
FAU - Mann, Annabelle
AU  - Mann A
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Paediatr Child Health
JT  - Journal of paediatrics and child health
JID - 9005421
SB  - IM
MH  - Age Factors
MH  - Australia
MH  - Disorders of Sex Development/*surgery
MH  - Gender Identity
MH  - Human Rights/*legislation & jurisprudence
MH  - Humans
MH  - Infant
MH  - Parental Consent/*ethics/*legislation & jurisprudence
MH  - Patient Advocacy/ethics/legislation & jurisprudence
MH  - Urogenital Surgical Procedures/*ethics
EDAT- 2011/09/29 06:00
MHDA- 2012/02/02 06:00
CRDT- 2011/09/29 06:00
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/02/02 06:00 [medline]
AID - 10.1111/j.1440-1754.2011.02164.x [doi]
PST - ppublish
SO  - J Paediatr Child Health. 2011 Sep;47(9):661-3. doi:
      10.1111/j.1440-1754.2011.02164.x.


PMID- 21951452
OWN - NLM
STAT- MEDLINE
DCOM- 20120201
LR  - 20110928
IS  - 1440-1754 (Electronic)
IS  - 1034-4810 (Linking)
VI  - 47
IP  - 9
DP  - 2011 Sep
TI  - Going against the grain: Liam's story.
PG  - 656-8
LID - 10.1111/j.1440-1754.2011.02162.x [doi]
AB  - You might well say, 'Why would you want to write about your son's death?' And in 
      response I may ask, 'Why do you want to read it?' Perhaps there are no correct
      answers to our questions, except to say that the only way we learn it, ethically,
      through the experiences of others as we witness their suffering. Although, for
      the most part, this journey would leave me feeling professionally abandoned,
      there were still times of joy, hope and love. I invite you to take this journey
      with me.
CI  - (c) 2011 The Author. Journal of Paediatrics and Child Health (c) 2011 Paediatrics
      and Child Health Division (Royal Australasian College of Physicians).
FAU - Thiele, Pauline
AU  - Thiele P
AD  - Red Hill South, Victoria, Australia. Liam194@gmail.com
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Paediatr Child Health
JT  - Journal of paediatrics and child health
JID - 9005421
SB  - IM
CIN - J Paediatr Child Health. 2011 Sep;47(9):659-60. PMID: 21951453
MH  - Australia
MH  - Beneficence
MH  - *Chromosomes, Human, Pair 18
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - Obstetrics/ethics
MH  - Patient Advocacy/*ethics
MH  - Pediatrics/ethics
MH  - Perinatal Care/*ethics
MH  - Pregnancy
MH  - Professional-Patient Relations/*ethics
MH  - Stillbirth/psychology
MH  - *Trisomy
EDAT- 2011/09/29 06:00
MHDA- 2012/02/02 06:00
CRDT- 2011/09/29 06:00
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/02/02 06:00 [medline]
AID - 10.1111/j.1440-1754.2011.02162.x [doi]
PST - ppublish
SO  - J Paediatr Child Health. 2011 Sep;47(9):656-8. doi:
      10.1111/j.1440-1754.2011.02162.x.


PMID- 21951451
OWN - NLM
STAT- MEDLINE
DCOM- 20120201
LR  - 20131121
IS  - 1440-1754 (Electronic)
IS  - 1034-4810 (Linking)
VI  - 47
IP  - 9
DP  - 2011 Sep
TI  - Science and ethics of human immunodeficiency virus/acquired immunodeficiency
      syndrome controversies in Africa.
PG  - 646-55
LID - 10.1111/j.1440-1754.2011.02179.x [doi]
AB  - The human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS)
      epidemic in Africa has raised important ethical issues for both researchers and
      clinicians. The most notorious controversy has been related to the zidovudine
      (AZT) trials in Africa in the late 1990s, in which the control groups were given 
      a placebo rather than an effective drug to prevent vertical transmission. This
      raised concerns in the sponsoring country about exploitation of subjects,
      injustice and an ethical double standard between donor countries and
      resource-poor settings. However, the real double standard is between clinical
      practice standards in Western versus African countries, which must be addressed
      as part of the increasing global inequity of wealth both between countries and
      also within countries. There are important limitations to ethical declarations,
      principles and guidelines on their own without contextual ethical reasoning. The 
      focus on research ethics with the HIV epidemic has led to a relative neglect of
      ethical issues in clinical practice. Although the scientific advances in HIV/AIDS
      have changed the ethical issues since the 1990s, there has also been progress in 
      the bioethics of HIV/AIDS in terms of ethical review capability by local
      committees as well as in exposure to ethical issues by clinicians and researchers
      in Africa. However, serious concerns remain about the overregulation of research 
      by bureaucratic agencies which could discourage African research on specifically 
      African health issues. There is also a need for African academic institutions and
      researchers to progressively improve their research capacity with the assistance 
      of research funders and donor agencies.
CI  - (c) 2011 The Author. Journal of Paediatrics and Child Health (c) 2011 Paediatrics
      and Child Health Division (Royal Australasian College of Physicians).
FAU - Brewster, David
AU  - Brewster D
AD  - School of Medicine, University of Botswana, Gaborone, Botswana.
      david.brewster48@gmail.com
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Paediatr Child Health
JT  - Journal of paediatrics and child health
JID - 9005421
RN  - 0 (Anti-HIV Agents)
RN  - 4B9XT59T7S (Zidovudine)
SB  - IM
MH  - Africa
MH  - Anti-HIV Agents/administration & dosage
MH  - Antiretroviral Therapy, Highly Active/ethics
MH  - Breast Feeding/ethics
MH  - Circumcision, Male/ethics
MH  - Confidentiality/ethics
MH  - Female
MH  - Guidelines as Topic
MH  - HIV Infections/diagnosis/*therapy
MH  - Health Care Rationing/ethics
MH  - *Healthcare Disparities
MH  - Helsinki Declaration
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Infant, Newborn
MH  - Intensive Care Units/supply & distribution
MH  - Male
MH  - Pregnancy
MH  - Randomized Controlled Trials as Topic/ethics
MH  - Standard of Care/*ethics
MH  - Zidovudine/administration & dosage
EDAT- 2011/09/29 06:00
MHDA- 2012/02/02 06:00
CRDT- 2011/09/29 06:00
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/02/02 06:00 [medline]
AID - 10.1111/j.1440-1754.2011.02179.x [doi]
PST - ppublish
SO  - J Paediatr Child Health. 2011 Sep;47(9):646-55. doi:
      10.1111/j.1440-1754.2011.02179.x.


PMID- 21951450
OWN - NLM
STAT- MEDLINE
DCOM- 20120201
LR  - 20110928
IS  - 1440-1754 (Electronic)
IS  - 1034-4810 (Linking)
VI  - 47
IP  - 9
DP  - 2011 Sep
TI  - Ethical advocacy based on caring: a model for neonatal and paediatric nurses.
PG  - 642-5
LID - 10.1111/j.1440-1754.2011.02178.x [doi]
AB  - Advocacy has been identified as an ideal in nursing practice. National codes
      (Australian Nursing and Midwifery Council) and professional standards (Australian
      College of Neonatal Nurses) state that nurses are to respect their patients'
      autonomous choices and act as their advocates. This responsibility includes
      acting as advocates for the needs and welfare of patients, for the profession of 
      nursing and for the interests of colleagues in nursing. However, ambiguous
      interpretations of the concept of patient advocacy continue to pose a number of
      problems for nurses in practice and in particular neonatal practice. Neonatal
      nurses often perceive themselves primarily as advocates for the rights of
      helpless and vulnerable infants in their care. Advocacy is underpinned by caring,
      which is a significant feature in the delivery of quality care for each baby and 
      child. This advocacy may be expressed at the bedside, in committee meetings, in
      agency discussions or in the public arena.
CI  - (c) 2011 The Author. Journal of Paediatrics and Child Health (c) 2011 Paediatrics
      and Child Health Division (Royal Australasian College of Physicians).
FAU - Spence, Kaye
AU  - Spence K
AD  - Grace Centre for Newborn Care, The Sydney Children's Hospitals Network
      (Westmead), New South Wales, Australia. kaye@chw.edu.au
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Paediatr Child Health
JT  - Journal of paediatrics and child health
JID - 9005421
SB  - IM
MH  - Australia
MH  - Decision Making/ethics
MH  - Humans
MH  - Infant, Newborn
MH  - Neonatal Nursing/*ethics
MH  - Nurse-Patient Relations/ethics
MH  - Patient Advocacy/*ethics
MH  - Pediatric Nursing/*ethics
MH  - Professional-Family Relations/ethics
EDAT- 2011/09/29 06:00
MHDA- 2012/02/02 06:00
CRDT- 2011/09/29 06:00
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/02/02 06:00 [medline]
AID - 10.1111/j.1440-1754.2011.02178.x [doi]
PST - ppublish
SO  - J Paediatr Child Health. 2011 Sep;47(9):642-5. doi:
      10.1111/j.1440-1754.2011.02178.x.


PMID- 21951449
OWN - NLM
STAT- MEDLINE
DCOM- 20120201
LR  - 20110928
IS  - 1440-1754 (Electronic)
IS  - 1034-4810 (Linking)
VI  - 47
IP  - 9
DP  - 2011 Sep
TI  - Organ donation in Australia.
PG  - 637-41
LID - 10.1111/j.1440-1754.2011.02176.x [doi]
AB  - Organ donation in Australia has undergone a series of important changes in the
      past 3 years. An ethically complex and emotionally profound subject, important
      questions are being raised about the approach to organ donation by the
      government, by health-care professionals and also by the public. This paper
      highlights some of the changes within the Australian organ donation community and
      explores several controversies that accompany the widespread implementation of
      measures aimed at significantly improving organ donation throughout the country.
CI  - (c) 2011 The Author. Journal of Paediatrics and Child Health (c) 2011 Paediatrics
      and Child Health Division (Royal Australasian College of Physicians).
FAU - Oberender, Felix
AU  - Oberender F
AD  - Monash Medical Centre, Intensive Care Unit, Clayton Campus, Victoria, Australia. 
      felix.oberender@southernhealth.org.au
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Paediatr Child Health
JT  - Journal of paediatrics and child health
JID - 9005421
SB  - IM
MH  - Australia
MH  - Humans
MH  - Informed Consent/ethics
MH  - Remuneration
MH  - Tissue Donors/*supply & distribution
MH  - Tissue and Organ Procurement/*ethics/legislation & jurisprudence/*trends
MH  - Waiting Lists
EDAT- 2011/09/29 06:00
MHDA- 2012/02/02 06:00
CRDT- 2011/09/29 06:00
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/02/02 06:00 [medline]
AID - 10.1111/j.1440-1754.2011.02176.x [doi]
PST - ppublish
SO  - J Paediatr Child Health. 2011 Sep;47(9):637-41. doi:
      10.1111/j.1440-1754.2011.02176.x.


PMID- 21951448
OWN - NLM
STAT- MEDLINE
DCOM- 20120201
LR  - 20220317
IS  - 1440-1754 (Electronic)
IS  - 1034-4810 (Linking)
VI  - 47
IP  - 9
DP  - 2011 Sep
TI  - Role and function of a paediatric clinical ethics service: experiences at the
      Royal Children's Hospital, Melbourne.
PG  - 632-6
LID - 10.1111/j.1440-1754.2011.02171.x [doi]
AB  - This article explores and analyses the role and functions of a clinical ethics
      service in paediatrics. It is based on the experiences of developing ethics
      capacity at the Royal Children's Hospital, Melbourne, which has evolved since
      2002 from a multidisciplinary advisory panel into Australia's first dedicated
      paediatric Children's Bioethics Centre, which opened in 2008. The ultimate goal
      is building ethics capacity and literacy across the hospital and continuing to
      support clinical staff managing patients and their families in ethically
      problematic cases. This is achieved through current case consultation, education 
      and training, research and institutional policy, and guideline development. The
      experience of building a clinical ethics service has led to many changes to its
      structure over the years, with issues like timeliness of meeting, constitution of
      the group and referral and reporting structures arising as key elements of
      evolution. Challenges include resourcing and structure, institutional support,
      and family involvement in ethics consultations.
CI  - (c) 2011 The Authors. Journal of Paediatrics and Child Health (c) 2011
      Paediatrics and Child Health Division (Royal Australasian College of Physicians).
FAU - Gold, Hugo
AU  - Gold H
AD  - Children's Bioethics Centre, The Royal Children's Hospital, Melbourne, Victoria, 
      Australia.
FAU - Hall, Georgina
AU  - Hall G
FAU - Gillam, Lynn
AU  - Gillam L
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Paediatr Child Health
JT  - Journal of paediatrics and child health
JID - 9005421
SB  - IM
MH  - Child
MH  - *Ethics Committees, Clinical/organization & administration
MH  - Hospitals, Pediatric/ethics
MH  - Humans
MH  - Organizational Objectives
MH  - Pediatrics/*ethics
MH  - Program Development
MH  - Referral and Consultation
MH  - Victoria
EDAT- 2011/09/29 06:00
MHDA- 2012/02/02 06:00
CRDT- 2011/09/29 06:00
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/02/02 06:00 [medline]
AID - 10.1111/j.1440-1754.2011.02171.x [doi]
PST - ppublish
SO  - J Paediatr Child Health. 2011 Sep;47(9):632-6. doi:
      10.1111/j.1440-1754.2011.02171.x.


PMID- 21951447
OWN - NLM
STAT- MEDLINE
DCOM- 20120201
LR  - 20110928
IS  - 1440-1754 (Electronic)
IS  - 1034-4810 (Linking)
VI  - 47
IP  - 9
DP  - 2011 Sep
TI  - Parents know best: or do they? Treatment refusals in paediatric oncology.
PG  - 628-31
LID - 10.1111/j.1440-1754.2011.02170.x [doi]
AB  - Although treatment refusal is an infrequent occurrence in paediatric oncology, it
      is an important issue that threatens the ongoing therapeutic relationship between
      the health-care team and families. While there are good reasons to support the
      decision-making authority of parents in the medical setting, parents' rights in
      this respect are not absolute. Fortunately, most disagreements between clinicians
      and parents regarding treatment decisions for children are resolved within the
      health-care team/family dyad or with the objective advice of other clinicians or 
      clinical ethics services. The increasing appeal of 'natural therapies' and
      unsubstantiated confidence with which they are prescribed may lead to more
      frequent refusal of conventional, evidence-based oncology treatment in the
      future. The harm principle may assist paediatric oncologists in the difficult
      task of determining when it is justifiable to refer a case for judicial
      intervention.
CI  - (c) 2011 The Author. Journal of Paediatrics and Child Health (c) 2011 Paediatrics
      and Child Health Division (Royal Australasian College of Physicians).
FAU - Alessandri, Angela J
AU  - Alessandri AJ
AD  - Department of Haematology/Oncology, Princess Margaret Hospital for Children and
      the School of Paediatrics and Child Health, University of Western Australia,
      Perth, Western Australia, Australia. angela.alessandri@health.wa.gov.au
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Australia
TA  - J Paediatr Child Health
JT  - Journal of paediatrics and child health
JID - 9005421
SB  - IM
MH  - Australia
MH  - Child
MH  - Child Welfare/ethics/legislation & jurisprudence
MH  - Decision Making/ethics
MH  - Fatal Outcome
MH  - Female
MH  - Hepatoblastoma/secondary/therapy
MH  - Humans
MH  - Liver Neoplasms/pathology/therapy
MH  - Male
MH  - Neoplasms/*therapy
MH  - Parental Consent/*ethics/*legislation & jurisprudence
MH  - Professional-Family Relations/ethics
MH  - Treatment Refusal/*ethics/*legislation & jurisprudence
EDAT- 2011/09/29 06:00
MHDA- 2012/02/02 06:00
CRDT- 2011/09/29 06:00
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/02/02 06:00 [medline]
AID - 10.1111/j.1440-1754.2011.02170.x [doi]
PST - ppublish
SO  - J Paediatr Child Health. 2011 Sep;47(9):628-31. doi:
      10.1111/j.1440-1754.2011.02170.x.


PMID- 21951445
OWN - NLM
STAT- MEDLINE
DCOM- 20120201
LR  - 20110928
IS  - 1440-1754 (Electronic)
IS  - 1034-4810 (Linking)
VI  - 47
IP  - 9
DP  - 2011 Sep
TI  - Ethics, law and paediatric medicine.
PG  - 620-3
LID - 10.1111/j.1440-1754.2011.02167.x [doi]
AB  - Medicine is practised within an ethical and a legal framework. Doctors must
      obtain the broad consent of their patients before treatment begins, and tell them
      of their choices and the material risks inherent in treatment. Where children are
      the patients, it is their parents or guardians who must give their consent,
      unless the situation is an emergency or the children have been removed from
      parental custody and care. Today, mature teenagers may consent to their own
      medical treatment. Doctors must protect their patients' confidential information,
      however acquired. There are very limited exceptions where confidential
      information may be revealed, and a few where revelation is mandatory. Effective
      communication between doctors and their patients, or their parents, is of signal 
      importance.
CI  - (c) 2011 The Author. Journal of Paediatrics and Child Health (c) 2011 Paediatrics
      and Child Health Division (Royal Australasian College of Physicians).
FAU - Waller, Louis
AU  - Waller L
AD  - Faculty of Law, Monash University, Melbourne, Victoria, Australia.
      louis.waller@law.monash.edu.au
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Paediatr Child Health
JT  - Journal of paediatrics and child health
JID - 9005421
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Confidentiality/ethics
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - Minors/legislation & jurisprudence
MH  - Parental Consent/ethics/legislation & jurisprudence
MH  - Pediatrics/*ethics/*legislation & jurisprudence
MH  - Physician-Patient Relations/ethics
EDAT- 2011/09/29 06:00
MHDA- 2012/02/02 06:00
CRDT- 2011/09/29 06:00
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/02/02 06:00 [medline]
AID - 10.1111/j.1440-1754.2011.02167.x [doi]
PST - ppublish
SO  - J Paediatr Child Health. 2011 Sep;47(9):620-3. doi:
      10.1111/j.1440-1754.2011.02167.x.


PMID- 21951444
OWN - NLM
STAT- MEDLINE
DCOM- 20120201
LR  - 20110928
IS  - 1440-1754 (Electronic)
IS  - 1034-4810 (Linking)
VI  - 47
IP  - 9
DP  - 2011 Sep
TI  - Ethical issues in bone marrow transplantation in children.
PG  - 614-9
LID - 10.1111/j.1440-1754.2011.02165.x [doi]
AB  - In the 50 years since the first successful human bone marrow transplant (BMT) was
      performed in 1959, BMT has become the optimal therapy for a wide variety of
      life-threatening paediatric haematological, immunological and genetic disorders. 
      Unfortunately, while BMT generally provides the only possibility of cure for such
      afflicted children, few (25%) have a matched sibling available, and suitably
      matched unrelated donors are often not identified for many children in need of
      BMT. And even where BMT is possible, treatment is complex and arduous and
      associated with significant mortality and morbidity. The issues raised when
      either or both the donor and recipient are children and lack the capacity to make
      informed and rational decisions relating to BMT pose great challenges for all
      involved. This paper examines some of the ethical dilemmas that confront
      patients, families and medical practitioners when considering bone marrow
      transplantation in a child.
CI  - (c) 2011 The Authors. Journal of Paediatrics and Child Health (c) 2011
      Paediatrics and Child Health Division (Royal Australasian College of Physicians).
FAU - Bendorf, Aric
AU  - Bendorf A
AD  - The Centre for Values, Ethics and the Law in Medicine, Sydney Medical School,
      University of Sydney, Sydney, New South Wales, Australia.
      aric.bendorf@sydney.edu.au
FAU - Kerridge, Ian H
AU  - Kerridge IH
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Paediatr Child Health
JT  - Journal of paediatrics and child health
JID - 9005421
SB  - IM
MH  - Bone Marrow Transplantation/adverse effects/*ethics/mortality
MH  - Child
MH  - Directed Tissue Donation/*ethics
MH  - Humans
MH  - Postoperative Complications/epidemiology
MH  - Risk Assessment
MH  - *Siblings
MH  - Stem Cell Transplantation/adverse effects/*ethics/mortality
MH  - Survival Rate
MH  - Tissue and Organ Harvesting/adverse effects
MH  - Transplantation, Autologous
MH  - Transplantation, Homologous
EDAT- 2011/09/29 06:00
MHDA- 2012/02/02 06:00
CRDT- 2011/09/29 06:00
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/02/02 06:00 [medline]
AID - 10.1111/j.1440-1754.2011.02165.x [doi]
PST - ppublish
SO  - J Paediatr Child Health. 2011 Sep;47(9):614-9. doi:
      10.1111/j.1440-1754.2011.02165.x.


PMID- 21951442
OWN - NLM
STAT- MEDLINE
DCOM- 20120201
LR  - 20110928
IS  - 1440-1754 (Electronic)
IS  - 1034-4810 (Linking)
VI  - 47
IP  - 9
DP  - 2011 Sep
TI  - Too big to swallow.
PG  - 608-9
LID - 10.1111/j.1440-1754.2011.02161.x [doi]
AB  - The failure of current treatment approaches to severe obesity has resulted in
      significant investment by the scientific community to develop new treatments for 
      this challenging health problem. Any new treatment must be scientifically tested 
      to determine its potential role and any innovation in healthcare can be
      associated with moral and ethical challenges. This reflective piece is based on
      the experience of running the first randomised controlled trial to compare
      laparoscopic adjustable gastric banding to an intensive behaviourally-based
      intervention in adolescents with severe obesity during which many moral and
      ethical concerns were articulated by other health professionals. Five different
      types of responses are described (preventers, druggies, deferrers, slippery
      slopers and simplifiers). While raising important concerns, these responses also 
      deflect attention from the urgent need to develop and test new treatments for the
      most severely obese adolescents. The stigma of obesity is posed as an underlying 
      yet unaddressed issue.
CI  - (c) 2011 The Author. Journal of Paediatrics and Child Health (c) 2011 Paediatrics
      and Child Health Division (Royal Australasian College of Physicians).
FAU - Sawyer, Susan M
AU  - Sawyer SM
AD  - Centre for Adolescent Health, Royal Children's Hospital, Victoria, Australia.
      Susan.sawyer@rch.org.au
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Paediatr Child Health
JT  - Journal of paediatrics and child health
JID - 9005421
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Attitude of Health Personnel
MH  - Australia
MH  - Behavior Therapy
MH  - Combined Modality Therapy
MH  - Gastroplasty/*ethics
MH  - Humans
MH  - Obesity, Morbid/*surgery
MH  - Randomized Controlled Trials as Topic
EDAT- 2011/09/29 06:00
MHDA- 2012/02/02 06:00
CRDT- 2011/09/29 06:00
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/02/02 06:00 [medline]
AID - 10.1111/j.1440-1754.2011.02161.x [doi]
PST - ppublish
SO  - J Paediatr Child Health. 2011 Sep;47(9):608-9. doi:
      10.1111/j.1440-1754.2011.02161.x.


PMID- 21951440
OWN - NLM
STAT- MEDLINE
DCOM- 20120201
LR  - 20110928
IS  - 1440-1754 (Electronic)
IS  - 1034-4810 (Linking)
VI  - 47
IP  - 9
DP  - 2011 Sep
TI  - Ethical considerations in paediatric neurology: neuromuscular disease and
      epilepsy.
PG  - 599-602
LID - 10.1111/j.1440-1754.2011.02159.x [doi]
AB  - The pace of developing technology with respect to many diagnostic tests, as well 
      as available treatments including artificial ventilation, may have progressed at 
      a faster rate than our ethical, humane ability to decide on the optimal choices
      for our patients. In fact, who should make these choices; physicians or patients 
      and families? Certain ethical aspects of neuromuscular disorders and epilepsy are
      reviewed. For neuromuscular disease, the example of Duchenne muscular dystrophy
      (DMD) with regards to genetic testing, relatively early wheelchair placement and 
      individualised invasive ventilation is discussed. In epilepsy, performing
      neurosurgery in severely impaired children is probably appropriate in some cases 
      if desired by the family. Financial and human costs restrict therapies and
      testing for epilepsy as well as other neurological and medical diseases. Whether 
      it is ethical to consider costs in medical treatment or not, it is certainly a
      reality.
CI  - (c) 2011 The Authors. Journal of Paediatrics and Child Health (c) 2011
      Paediatrics and Child Health Division (Royal Australasian College of Physicians).
FAU - Bodensteiner, John B
AU  - Bodensteiner JB
AD  - Division of Pediatric Neurology, Barrow Neurological Institute/St. Joseph's
      Children's Health Center, Phoenix, Arizona, United States.
FAU - Ng, Yu-Tze
AU  - Ng YT
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Paediatr Child Health
JT  - Journal of paediatrics and child health
JID - 9005421
RN  - 0 (Anticonvulsants)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
SB  - IM
MH  - Adrenocorticotropic Hormone/therapeutic use
MH  - Anticonvulsants/therapeutic use
MH  - Carrier State/diagnosis
MH  - Cerebral Palsy/complications
MH  - Child
MH  - Decision Making/*ethics
MH  - Epilepsy/drug therapy/etiology/*surgery
MH  - Female
MH  - Health Care Costs
MH  - Humans
MH  - Intellectual Disability/complications
MH  - Life Support Care/ethics
MH  - Male
MH  - Muscular Dystrophy, Duchenne/diagnosis/*therapy
MH  - Neurology/ethics
MH  - Quality of Life
MH  - Truth Disclosure/ethics
MH  - Vagus Nerve Stimulation
MH  - Wheelchairs
EDAT- 2011/09/29 06:00
MHDA- 2012/02/02 06:00
CRDT- 2011/09/29 06:00
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/02/02 06:00 [medline]
AID - 10.1111/j.1440-1754.2011.02159.x [doi]
PST - ppublish
SO  - J Paediatr Child Health. 2011 Sep;47(9):599-602. doi:
      10.1111/j.1440-1754.2011.02159.x.


PMID- 21951439
OWN - NLM
STAT- MEDLINE
DCOM- 20120201
LR  - 20110928
IS  - 1440-1754 (Electronic)
IS  - 1034-4810 (Linking)
VI  - 47
IP  - 9
DP  - 2011 Sep
TI  - Ethics at the end of life: who should make decisions about treatment limitation
      for young children with life-threatening or life-limiting conditions?
PG  - 594-8
LID - 10.1111/j.1440-1754.2011.02177.x [doi]
AB  - It is now ethical orthodoxy that parents should be involved in the
      decision-making about their children's health care. This extends to decisions
      about whether to continue or to limit life-sustaining medical treatment for a
      child with a life-limiting or life-threatening condition. What remains contested 
      and uncertain is the extent and nature of parental involvement, especially in
      this emotionally charged situation. In particular, should it be the parents, who 
      are the ultimate decision-makers, taking final responsibility, should it be a
      shared decision, or should it be a medical decision that parents are simply asked
      to consent to? One approach to this issue is to consider the in-principle ethical
      arguments and weigh their merits. The two key principles here are parental rights
      and authority, and the best interests of child, and the contested issue is what
      to do if these appear to clash. Another approach is to consider the principles in
      the practical clinical context. What would be the implications and consequences
      of adopting the model of parents as final decision-makers? Are parents able to
      carry out this role, and do they really want it? What is the effect on parents of
      taking this role? Answers to these questions could modify the in-principle
      ethical position. In this paper, we review the empirical evidence currently
      available on these questions, in relation to parents of infants and young
      children. Overall, the literature suggests that parents do want to be involved
      and do not suffer adverse psychological consequences from their involvement.
      However, the crucial ethical implication of the evidence is that the level and
      nature of parental involvement in decision-making should be negotiated with the
      parents in each case, because parents have a range of different views about
      taking final responsibility for decisions.
CI  - (c) 2011 The Authors. Journal of Paediatrics and Child Health (c) 2011
      Paediatrics and Child Health Division (Royal Australasian College of Physicians).
FAU - Gillam, Lynn
AU  - Gillam L
AD  - Children's Bioethics Centre, Royal Children's Hospital Melbourne, Victoria,
      Australia. l.gillam@unimelb.edu.au
FAU - Sullivan, Jane
AU  - Sullivan J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - J Paediatr Child Health
JT  - Journal of paediatrics and child health
JID - 9005421
SB  - IM
MH  - Decision Making/ethics
MH  - Humans
MH  - Infant, Newborn
MH  - Intensive Care Units, Neonatal/ethics
MH  - Intensive Care, Neonatal/*ethics
MH  - Neonatology/ethics
MH  - Parental Consent/ethics
MH  - *Parents
MH  - Professional-Family Relations/*ethics
MH  - Terminal Care/*ethics
MH  - Withholding Treatment/*ethics
EDAT- 2011/09/29 06:00
MHDA- 2012/02/02 06:00
CRDT- 2011/09/29 06:00
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/02/02 06:00 [medline]
AID - 10.1111/j.1440-1754.2011.02177.x [doi]
PST - ppublish
SO  - J Paediatr Child Health. 2011 Sep;47(9):594-8. doi:
      10.1111/j.1440-1754.2011.02177.x.


PMID- 21951438
OWN - NLM
STAT- MEDLINE
DCOM- 20120201
LR  - 20110928
IS  - 1440-1754 (Electronic)
IS  - 1034-4810 (Linking)
VI  - 47
IP  - 9
DP  - 2011 Sep
TI  - Expressing ethical principles of treatment and care in a charter: what value?
PG  - 590-3
LID - 10.1111/j.1440-1754.2011.02158.x [doi]
AB  - More than ever before, public institutions are expected to have accessible
      guidelines on what they do, both for their staff and for those served by them.
      With this in mind, some principles of treatment and care of sick children were
      drafted for the Children's Hospital at Westmead. These were centred on ethics,
      primarily of what was best for the child. They were neither all-inclusive nor
      specific. They were labelled as a charter. They were rejected by a parent
      committee and met with unenthusiastic responses at meetings of hospital and
      ethics professionals. Reasons for this are unclear, but it is speculated that
      fear of the unknown and distrust of institutions may be factors. To date, the
      charter has not proved useful, except in provoking further discussion on how
      general guidelines are written, used and valued and on end-of-life
      decision-making more generally.
CI  - (c) 2011 The Author. Journal of Paediatrics and Child Health (c) 2011 Paediatrics
      and Child Health Division (Royal Australasian College of Physicians).
FAU - Kilham, Henry A
AU  - Kilham HA
AD  - General Medicine and Clinical Ethics, The Children's Hospital at Westmead, New
      South Wales, Australia. henryk@chw.edu.au
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Paediatr Child Health
JT  - Journal of paediatrics and child health
JID - 9005421
SB  - IM
MH  - *Attitude to Health
MH  - Child
MH  - Decision Making/ethics
MH  - *Ethics, Institutional
MH  - Hospitals, Pediatric/*ethics
MH  - Humans
MH  - Life Support Care/ethics
MH  - New South Wales
MH  - Parents
MH  - *Practice Guidelines as Topic
MH  - Terminal Care/*ethics
EDAT- 2011/09/29 06:00
MHDA- 2012/02/02 06:00
CRDT- 2011/09/29 06:00
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/02/02 06:00 [medline]
AID - 10.1111/j.1440-1754.2011.02158.x [doi]
PST - ppublish
SO  - J Paediatr Child Health. 2011 Sep;47(9):590-3. doi:
      10.1111/j.1440-1754.2011.02158.x.


PMID- 21951437
OWN - NLM
STAT- MEDLINE
DCOM- 20120201
LR  - 20110928
IS  - 1440-1754 (Electronic)
IS  - 1034-4810 (Linking)
VI  - 47
IP  - 9
DP  - 2011 Sep
TI  - Improved neonatal survival and outcomes at borderline viability brings increasing
      ethical dilemmas.
PG  - 585-9
LID - 10.1111/j.1440-1754.2011.02157.x [doi]
AB  - With improvements in neonatal intensive care over the past five decades, the
      limits of viability have reduced to around 24 weeks' gestation. While increasing 
      survival has been the predominant driver leading to lowering the gestation at
      which care can be provided, these infants remain at significant risk of adverse
      long-term outcomes including neuro-developmental disability. Decisions about
      commencing and continuing intensive care are determined in partnership with
      parents, considering the best interests of the baby and the family. Occasionally,
      clinicians and parents come to an impasse regarding institution or continuation
      of intensive care. Inevitably, these ethical dilemmas need to consider the
      uncertainty of the long-term prognosis and challenges surrounding providing or
      withdrawing active treatment. Further reduction in the gestational age considered
      for institution of intensive care will need to be guided by short- and long-term 
      outcomes, community expectations and the availability of sufficient resources to 
      care for these infants in the neonatal intensive care unit and beyond.
CI  - (c) 2011 The Authors. Journal of Paediatrics and Child Health (c) 2011
      Paediatrics and Child Health Division (Royal Australasian College of Physicians).
FAU - Kuschel, Carl A
AU  - Kuschel CA
AD  - Neonatal Services, the Royal Women's Hospital, Parkville, Australia.
      carl.kuschel@thewomens.org.au
FAU - Kent, Alison
AU  - Kent A
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Paediatr Child Health
JT  - Journal of paediatrics and child health
JID - 9005421
SB  - IM
MH  - Humans
MH  - *Infant, Extremely Low Birth Weight
MH  - Infant, Newborn
MH  - *Infant, Premature
MH  - Intensive Care, Neonatal/*ethics
MH  - Neonatology/ethics
MH  - Prognosis
MH  - Quality of Life
EDAT- 2011/09/29 06:00
MHDA- 2012/02/02 06:00
CRDT- 2011/09/29 06:00
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/02/02 06:00 [medline]
AID - 10.1111/j.1440-1754.2011.02157.x [doi]
PST - ppublish
SO  - J Paediatr Child Health. 2011 Sep;47(9):585-9. doi:
      10.1111/j.1440-1754.2011.02157.x.


PMID- 21951436
OWN - NLM
STAT- MEDLINE
DCOM- 20120201
LR  - 20220330
IS  - 1440-1754 (Electronic)
IS  - 1034-4810 (Linking)
VI  - 47
IP  - 9
DP  - 2011 Sep
TI  - Managing ethically questionable parental requests: growth suppression and
      manipulation of puberty.
PG  - 581-4
LID - 10.1111/j.1440-1754.2011.02156.x [doi]
AB  - Doctors sometimes struggle with ethically challenging requests for treatment from
      children's parents. For instance, we have recently had two requests by parents of
      children, a girl and a boy, each with a severe developmental disability, for
      hormonal therapy to suppress growth and puberty: the girl's parents requested, in
      addition, hysterectomy and mastectomy. We propose a reliable approach to
      assessing the ethical and legal aspects of these and other requests for
      'non-therapeutic' treatment of a minor who lacks the capacity to give informed
      consent. We argue that a doctor should first assess whether the request is one
      that he or she can, in conscience, accede to, and then, if it is, seek the
      authorisation of a court. We outline considerations relevant to the doctor's
      assessment of both the ethical issues and to the need for court authorisation.
CI  - (c) 2011 The Authors. Journal of Paediatrics and Child Health (c) 2011
      Paediatrics and Child Health Division (Royal Australasian College of Physicians).
FAU - Isaacs, David
AU  - Isaacs D
AD  - Clinical Ethics Advisory Committee, Children's Hospital at Westmead, Westmead,
      University of Sydney, Australia. davidi@chw.edu.au
FAU - Tobin, Bernadette
AU  - Tobin B
FAU - Hamblin, Julie
AU  - Hamblin J
FAU - Slaytor, Emma
AU  - Slaytor E
FAU - Donaghue, Kim C
AU  - Donaghue KC
FAU - Munns, Craig
AU  - Munns C
FAU - Kilham, Henry A
AU  - Kilham HA
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Paediatr Child Health
JT  - Journal of paediatrics and child health
JID - 9005421
RN  - 0 (Hormones)
SB  - IM
MH  - Australia
MH  - Child
MH  - Child Welfare/*ethics/*legislation & jurisprudence
MH  - Disabled Children/*legislation & jurisprudence
MH  - Female
MH  - *Growth
MH  - Hormones/*administration & dosage
MH  - Humans
MH  - *Intellectual Disability
MH  - Male
MH  - Parental Consent/ethics/legislation & jurisprudence
MH  - Pediatrics/ethics/legislation & jurisprudence
MH  - *Puberty
EDAT- 2011/09/29 06:00
MHDA- 2012/02/02 06:00
CRDT- 2011/09/29 06:00
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/02/02 06:00 [medline]
AID - 10.1111/j.1440-1754.2011.02156.x [doi]
PST - ppublish
SO  - J Paediatr Child Health. 2011 Sep;47(9):581-4. doi:
      10.1111/j.1440-1754.2011.02156.x.


PMID- 21951075
OWN - NLM
STAT- MEDLINE
DCOM- 20120228
LR  - 20111028
IS  - 1744-4144 (Electronic)
IS  - 1385-4046 (Linking)
VI  - 25
IP  - 7
DP  - 2011 Oct
TI  - Initial practice recommendations for teleneuropsychology.
PG  - 1119-33
LID - 10.1080/13854046.2011.609840 [doi]
AB  - Telemedicine refers to the use of electronic communications to deliver
      health-related services from a distance, and is particularly useful in bringing
      specialty services to remote and/or underserved areas. Despite the increasing use
      of videoconference technology in psychology, there are very few guidelines to
      direct practitioners as to the ethical practice and utilization of telemedicine, 
      and even fewer resources for practitioners of telecognitive assessment or
      teleneuropsychology. This paper seeks to outline several practical and ethical
      considerations that are relevant to the practice of telecognitive assessment and 
      to assist practitioners in providing safe, ethical, and competent care to their
      patients by proposing some initial practice recommendations.
FAU - Grosch, Maria C
AU  - Grosch MC
AD  - Department of Psychiatry, University of Texas Southwestern Medical Center,
      Dallas, TX 75390-9044, USA. maria.grosch@utsouthwestern.edu
FAU - Gottlieb, Michael C
AU  - Gottlieb MC
FAU - Cullum, C Munro
AU  - Cullum CM
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110927
PL  - England
TA  - Clin Neuropsychol
JT  - The Clinical neuropsychologist
JID - 8806548
SB  - IM
MH  - Humans
MH  - Neuropsychology/ethics/*methods
MH  - *Remote Consultation
MH  - *Rural Health Services
MH  - *Telemedicine
MH  - Videoconferencing
EDAT- 2011/09/29 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/09/29 06:00
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - 10.1080/13854046.2011.609840 [doi]
PST - ppublish
SO  - Clin Neuropsychol. 2011 Oct;25(7):1119-33. doi: 10.1080/13854046.2011.609840.
      Epub 2011 Sep 27.


PMID- 21950617
OWN - NLM
STAT- MEDLINE
DCOM- 20120302
LR  - 20130520
IS  - 1651-2227 (Electronic)
IS  - 0803-5253 (Linking)
VI  - 101
IP  - 1
DP  - 2012 Jan
TI  - Age assessment of young asylum seekers.
PG  - 4-7
LID - 10.1111/j.1651-2227.2011.02476.x [doi]
AB  - UNLABELLED: During 2009, 15,100 unaccompanied children sought asylum in Europe.
      Many of them came from 'failed states' like Somalia and Afghanistan where
      official documents with exact birth dates are rarely issued. This has led to
      requests to health care professionals in many countries to assist migration
      authorities in determining whether a young asylum seeker is a child or an adult. 
      Many different methods are currently employed in Europe for this purpose by
      dentists, paediatricians, radiographers and social workers, but no currently
      available method has been demonstrated to have the accuracy needed to be of real 
      use in this decision. Unclear guidelines and arbitrary practices may lead to
      alarming shortcomings in the protection of this high-risk group of children and
      adolescents in Europe. Medical participation, as well as non-participation, in
      these dubious decisions raises a number of ethical questions. CONCLUSION: To
      improve care for young asylum seekers with undetermined age, we suggest better
      legal procedures for the determination of age and a more flexible approach to
      chronological age.
CI  - (c) 2011 The Author(s)/Acta Paediatrica (c) 2011 Foundation Acta Paediatrica.
FAU - Hjern, Anders
AU  - Hjern A
AD  - Centre for Health Equity Studies, Karolinska Institutet/Stockholm University,
      Sweden. anders.hjern@chess.su.se
FAU - Brendler-Lindqvist, Maria
AU  - Brendler-Lindqvist M
FAU - Norredam, Marie
AU  - Norredam M
LA  - eng
PT  - Journal Article
DEP - 20111020
PL  - Norway
TA  - Acta Paediatr
JT  - Acta paediatrica (Oslo, Norway : 1992)
JID - 9205968
SB  - IM
MH  - Adolescent
MH  - Age Determination by Skeleton/methods
MH  - Age Determination by Teeth/methods
MH  - Age Factors
MH  - Bioethical Issues
MH  - Child
MH  - Europe
MH  - Female
MH  - Humans
MH  - Male
MH  - *Minors
MH  - Needs Assessment
MH  - Public Policy/*legislation & jurisprudence
MH  - *Refugees/psychology
EDAT- 2011/09/29 06:00
MHDA- 2012/03/03 06:00
CRDT- 2011/09/29 06:00
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/03/03 06:00 [medline]
AID - 10.1111/j.1651-2227.2011.02476.x [doi]
PST - ppublish
SO  - Acta Paediatr. 2012 Jan;101(1):4-7. doi: 10.1111/j.1651-2227.2011.02476.x. Epub
      2011 Oct 20.


PMID- 21950563
OWN - NLM
STAT- MEDLINE
DCOM- 20120913
LR  - 20220309
IS  - 1471-6712 (Electronic)
IS  - 0283-9318 (Linking)
VI  - 26
IP  - 2
DP  - 2012 Jun
TI  - How children handle life when their mother or father is seriously ill and dying.
PG  - 228-35
LID - 10.1111/j.1471-6712.2011.00922.x [doi]
AB  - AIMS AND OBJECTIVES: The aim of this study was to describe and understand how
      children handle their life when a mother or father is dying. METHODOLOGICAL
      DESIGN AND JUSTIFICATION: The research design was phenomenological hermeneutic.
      The phenomenological approach enabled us to capture the concrete everyday life of
      the children as it is understood and experienced by the children themselves. The 
      hermeneutical approach offered the possibility of reaching an understanding of
      the children's experiences. RESEARCH METHODS: Seven children aged 11-17 years
      participated in the study. Data were collected using qualitative interviews and
      video diaries. ETHICAL CONSIDERATIONS: The researcher complied with ethical
      guidelines that apply to all researchers and followed ethical guidelines for
      nursing research in the Nordic Countries (Northern Nurses Federation). The
      children's names were changed, and the data were treated confidentially.
      FINDINGS: Analysis produced an overarching theme of death's waiting room, with
      following sub-themes: Relating to death, when death becomes even more clearly
      manifest and handling life in death's waiting room. STUDY LIMITATIONS: This study
      focuses on a limited explored area; children's lived life with a dying parent.
      The study limits itself to focusing on children's life world; by choosing this
      focus, we have not included the relational aspects that are essential aspects of 
      children's lives. One might focus on these aspects in a second study to shed
      further light on the children's lives. CONCLUSION: When children live in a family
      with a dying mother or father, they find that their home is transformed from a
      safe base into death's waiting room. The children use a variety of ways to handle
      the confrontation with death. Avoiding talking to the children will not protect
      them from their thoughts about death.
CI  - (c) 2011 The Authors. Scandinavian Journal of Caring Sciences (c) 2011 Nordic
      College of Caring Science.
FAU - Buchwald, Dorte
AU  - Buchwald D
AD  - Vendsyssel Hospital, Denmark Aalborg Hospital, Aarhus University Hospital,
      Denmark. dobu@rn.dk
FAU - Delmar, Charlotte
AU  - Delmar C
FAU - Schantz-Laursen, Birgitte
AU  - Schantz-Laursen B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110923
PL  - Sweden
TA  - Scand J Caring Sci
JT  - Scandinavian journal of caring sciences
JID - 8804206
MH  - *Adaptation, Psychological
MH  - Adolescent
MH  - Adult
MH  - *Attitude to Death
MH  - Child
MH  - *Fathers
MH  - Female
MH  - Humans
MH  - Male
MH  - *Mothers
MH  - *Parent-Child Relations
EDAT- 2011/09/29 06:00
MHDA- 2012/09/14 06:00
CRDT- 2011/09/29 06:00
PHST- 2011/09/29 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/09/14 06:00 [medline]
AID - 10.1111/j.1471-6712.2011.00922.x [doi]
PST - ppublish
SO  - Scand J Caring Sci. 2012 Jun;26(2):228-35. doi: 10.1111/j.1471-6712.2011.00922.x.
      Epub 2011 Sep 23.


PMID- 21949447
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 0029-4624 (Print)
IS  - 0029-4624 (Linking)
VI  - 45
IP  - 1
DP  - 2011 Mar
TI  - Evolutionary Debunking Arguments.
PG  - 103-125
AB  - Evolutionary debunking arguments (EDAs) are arguments that appeal to the
      evolutionary origins of evaluative beliefs to undermine their justification. This
      paper aims to clarify the premises and presuppositions of EDAs-a form of argument
      that is increasingly put to use in normative ethics. I argue that such arguments 
      face serious obstacles. It is often overlooked, for example, that they presuppose
      the truth of metaethical objectivism. More importantly, even if objectivism is
      assumed, the use of EDAs in normative ethics is incompatible with a parallel and 
      more sweeping global evolutionary debunking argument that has been discussed in
      recent metaethics. After examining several ways of responding to this global
      debunking argument, I end by arguing that even if we could resist it, this would 
      still not rehabilitate the current targeted use of EDAs in normative ethics given
      that, if EDAs work at all, they will in any case lead to a truly radical revision
      of our evaluative outlook.
FAU - Kahane, Guy
AU  - Kahane G
AD  - University of Oxford.
LA  - eng
GR  - 086041/WT_/Wellcome Trust/United Kingdom
GR  - 087208/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PL  - United States
TA  - Nous
JT  - Nous (Detroit, Mich.)
JID - 100972833
PMC - PMC3175808
EDAT- 2011/09/29 06:00
MHDA- 2011/09/29 06:01
CRDT- 2011/09/28 06:00
PHST- 2011/09/28 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2011/09/29 06:01 [medline]
AID - 10.1111/j.1468-0068.2010.00770.x [doi]
PST - ppublish
SO  - Nous. 2011 Mar;45(1):103-125. doi: 10.1111/j.1468-0068.2010.00770.x.


PMID- 21949375
OWN - NLM
STAT- MEDLINE
DCOM- 20111213
LR  - 20220311
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 108
IP  - 40
DP  - 2011 Oct 4
TI  - Grafted human-induced pluripotent stem-cell-derived neurospheres promote motor
      functional recovery after spinal cord injury in mice.
PG  - 16825-30
LID - 10.1073/pnas.1108077108 [doi]
AB  - Once their safety is confirmed, human-induced pluripotent stem cells (hiPSCs),
      which do not entail ethical concerns, may become a preferred cell source for
      regenerative medicine. Here, we investigated the therapeutic potential of
      transplanting hiPSC-derived neurospheres (hiPSC-NSs) into nonobese diabetic
      (NOD)-severe combined immunodeficient (SCID) mice to treat spinal cord injury
      (SCI). For this, we used a hiPSC clone (201B7), established by transducing four
      reprogramming factors (Oct3/4, Sox2, Klf4, and c-Myc) into adult human
      fibroblasts. Grafted hiPSC-NSs survived, migrated, and differentiated into the
      three major neural lineages (neurons, astrocytes, and oligodendrocytes) within
      the injured spinal cord. They showed both cell-autonomous and noncell-autonomous 
      (trophic) effects, including synapse formation between hiPSC-NS-derived neurons
      and host mouse neurons, expression of neurotrophic factors, angiogenesis, axonal 
      regrowth, and increased amounts of myelin in the injured area. These positive
      effects resulted in significantly better functional recovery compared with
      vehicle-treated control animals, and the recovery persisted through the end of
      the observation period, 112 d post-SCI. No tumor formation was observed in the
      hiPSC-NS-grafted mice. These findings suggest that hiPSCs give rise to neural
      stem/progenitor cells that support improved function post-SCI and are a promising
      cell source for its treatment.
FAU - Nori, Satoshi
AU  - Nori S
AD  - Department of Physiology, School of Medicine, Keio University, Shinjuku, Tokyo
      160-8582, Japan.
FAU - Okada, Yohei
AU  - Okada Y
FAU - Yasuda, Akimasa
AU  - Yasuda A
FAU - Tsuji, Osahiko
AU  - Tsuji O
FAU - Takahashi, Yuichiro
AU  - Takahashi Y
FAU - Kobayashi, Yoshiomi
AU  - Kobayashi Y
FAU - Fujiyoshi, Kanehiro
AU  - Fujiyoshi K
FAU - Koike, Masato
AU  - Koike M
FAU - Uchiyama, Yasuo
AU  - Uchiyama Y
FAU - Ikeda, Eiji
AU  - Ikeda E
FAU - Toyama, Yoshiaki
AU  - Toyama Y
FAU - Yamanaka, Shinya
AU  - Yamanaka S
FAU - Nakamura, Masaya
AU  - Nakamura M
FAU - Okano, Hideyuki
AU  - Okano H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110926
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Cell Differentiation/physiology
MH  - Cell Movement/physiology
MH  - Electrophysiology
MH  - Female
MH  - Gene Expression Profiling
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*transplantation
MH  - Kruppel-Like Factor 4
MH  - Lentivirus
MH  - Mice
MH  - Mice, Inbred NOD
MH  - Mice, SCID
MH  - Nerve Regeneration/genetics/*physiology
MH  - Regenerative Medicine/*methods
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Rotarod Performance Test
MH  - Spinal Cord Injuries/*surgery
MH  - Synapses/physiology
MH  - Transduction, Genetic
PMC - PMC3189018
EDAT- 2011/09/29 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/09/28 06:00
PHST- 2011/09/28 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 1108077108 [pii]
AID - 10.1073/pnas.1108077108 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16825-30. doi:
      10.1073/pnas.1108077108. Epub 2011 Sep 26.


PMID- 21949081
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20191210
IS  - 1460-2105 (Electronic)
IS  - 0027-8874 (Linking)
VI  - 103
IP  - 20
DP  - 2011 Oct 19
TI  - Company stock prices before and after public announcements related to oncology
      drugs.
PG  - 1507-12
LID - 10.1093/jnci/djr338 [doi]
AB  - BACKGROUND: Phase III clinical trials and Food and Drug Administration (FDA)
      regulatory decisions are critical for success of new drugs and can influence a
      company's market valuation. Knowledge of trial results before they are made
      public (ie, "inside information") can affect the price of a drug company's stock.
      We examined the stock prices of companies before and after public announcements
      regarding experimental anticancer drugs owned by the companies. METHODS: We
      identified drugs that were undergoing evaluation in phase III trials or for
      regulatory approval by the US FDA from January 2000 to January 2009. Stock prices
      of companies that owned such drugs were analyzed for 120 trading days before and 
      after the first public announcement of 1) results of clinical trials with
      positive and negative outcomes and 2) positive and negative regulatory decisions.
      All statistical tests were two-sided. RESULTS: We identified public announcements
      from 23 positive trials and 36 negative trials and from 41 positive and nine
      negative FDA regulatory decisions. The mean stock price for the 120 trading days 
      before a phase III clinical trial announcement increased by 13.7% (95% confidence
      interval = -2.2% to 29.6%) for companies that reported positive trials and
      decreased by 0.7% (95% confidence interval = -13.8% to 12.3%) for companies that 
      reported negative trials (P = .09). In a post hoc analysis comparing the stock
      price averaged over 60 trading days before and after day -60 relative to the
      clinical trial announcement, the mean stock price increased by 9.4% for companies
      that reported positive trials and decreased by 4.5% for companies that reported
      negative trials (P = .03). Changes in company stock prices before FDA regulatory 
      decisions did not differ statistically between companies with positive decision
      and companies with negative decisions. CONCLUSIONS: Trends in company stock
      prices before the first public announcement differ for companies that report
      positive vs negative trials. This finding has important legal and ethical
      implications for investigators, drug companies, and the investment industry.
FAU - Rothenstein, Jeffrey M
AU  - Rothenstein JM
AD  - Department of Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, ON,
      Canada.
FAU - Tomlinson, George
AU  - Tomlinson G
FAU - Tannock, Ian F
AU  - Tannock IF
FAU - Detsky, Allan S
AU  - Detsky AS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110926
PL  - United States
TA  - J Natl Cancer Inst
JT  - Journal of the National Cancer Institute
JID - 7503089
RN  - 0 (Antineoplastic Agents)
SB  - IM
CIN - J Natl Cancer Inst. 2011 Oct 19;103(20):1488-9. PMID: 21949082
MH  - *Antineoplastic Agents/economics/therapeutic use
MH  - Clinical Trials, Phase III as Topic
MH  - *Commerce
MH  - Confounding Factors, Epidemiologic
MH  - Crime/economics/prevention & control
MH  - *Drug Approval
MH  - Drug Industry/*economics
MH  - Humans
MH  - *Investments
MH  - *Mass Media
MH  - *Private Sector/economics/ethics/legislation & jurisprudence
MH  - Retrospective Studies
MH  - Time Factors
MH  - Treatment Outcome
MH  - United States
MH  - United States Food and Drug Administration
EDAT- 2011/09/29 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/09/28 06:00
PHST- 2011/09/28 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - djr338 [pii]
AID - 10.1093/jnci/djr338 [doi]
PST - ppublish
SO  - J Natl Cancer Inst. 2011 Oct 19;103(20):1507-12. doi: 10.1093/jnci/djr338. Epub
      2011 Sep 26.


PMID- 21949053
OWN - NLM
STAT- MEDLINE
DCOM- 20120208
LR  - 20111006
IS  - 1744-5019 (Electronic)
IS  - 0360-5310 (Linking)
VI  - 36
IP  - 4
DP  - 2011 Aug
TI  - How should political philosophers think of health?
PG  - 424-35
LID - 10.1093/jmp/jhr026 [doi]
AB  - The political philosophy of health care has been characterized by considerable
      conceptual inflation in recent years. First, the concept of health that lies at
      its core has come to encompass ever-increasing aspects of individuals'
      existences. And second, the emergence of the public health perspective has
      increased the range of resources relevant to health equity. This expansion has
      not been without cost. The decision to include more rather than less within the
      ambit of "health" is ultimately a moral/political rather than an ontological or
      metaphysical one, and there are several ethical reasons to define the scope of
      theories of distributive justice in health narrowly.
FAU - Weinstock, Daniel M
AU  - Weinstock DM
AD  - University of Montreal, Montreal, Quebec, Canada.
      daniel.marc.weinstock@umontreal.ca
LA  - eng
PT  - Journal Article
DEP - 20110923
PL  - United States
TA  - J Med Philos
JT  - The Journal of medicine and philosophy
JID - 7610512
SB  - IM
MH  - Delivery of Health Care/*organization & administration
MH  - *Health
MH  - Humans
MH  - Morals
MH  - Philosophy, Medical
MH  - *Politics
MH  - *Public Health
EDAT- 2011/09/29 06:00
MHDA- 2012/02/09 06:00
CRDT- 2011/09/28 06:00
PHST- 2011/09/28 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/02/09 06:00 [medline]
AID - jhr026 [pii]
AID - 10.1093/jmp/jhr026 [doi]
PST - ppublish
SO  - J Med Philos. 2011 Aug;36(4):424-35. doi: 10.1093/jmp/jhr026. Epub 2011 Sep 23.


PMID- 21948806
OWN - NLM
STAT- MEDLINE
DCOM- 20120321
LR  - 20220310
IS  - 1468-3318 (Electronic)
IS  - 0964-4563 (Linking)
VI  - 21
IP  - 1
DP  - 2012 Jan
TI  - Businesses' voluntary pro-health tobacco policies: a review and research agenda.
PG  - 66-72
LID - 10.1136/tobaccocontrol-2011-050201 [doi]
AB  - Research on the role of businesses in tobacco control has focused primarily on
      retailers, advertising firms and the hospitality industry, all of which have
      tended to support tobacco industry interests and resist effective tobacco control
      policies. However, in several countries, businesses have a history of voluntarily
      adopting tobacco-related policies that may advance tobacco control objectives.
      These phenomena have received little research attention. Existing literature on
      businesses ending tobacco sales, instituting voluntary workplace smoking
      restrictions and establishing non-smoker only hiring policies was reviewed. A
      research agenda on voluntary business initiatives would enhance and complement
      research on mandatory tobacco control policies by identifying new advocacy
      opportunities; suggesting avenues for strengthening or reinforcing existing
      policy initiatives; laying the groundwork for new mandatory policies; helping to 
      inform ethical debates about contentious voluntary policies; and contributing to 
      a better understanding of how alliances between the tobacco industry and other
      businesses might be weakened.
FAU - McDaniel, Patricia A
AU  - McDaniel PA
AD  - Department of Social and Behavioral Sciences, University of California, San
      Francisco, California 94118, USA. patricia.mcdaniel@ucsf.edu
FAU - Malone, Ruth E
AU  - Malone RE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110926
PL  - England
TA  - Tob Control
JT  - Tobacco control
JID - 9209612
RN  - 0 (Tobacco Smoke Pollution)
SB  - IM
MH  - Commerce/*organization & administration
MH  - Health Policy
MH  - Humans
MH  - *Occupational Health
MH  - Personnel Selection/methods
MH  - *Smoking Prevention
MH  - Social Control, Informal
MH  - Tobacco Smoke Pollution/*prevention & control
MH  - Workplace/organization & administration
EDAT- 2011/09/29 06:00
MHDA- 2012/03/22 06:00
CRDT- 2011/09/28 06:00
PHST- 2011/09/28 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/03/22 06:00 [medline]
AID - tobaccocontrol-2011-050201 [pii]
AID - 10.1136/tobaccocontrol-2011-050201 [doi]
PST - ppublish
SO  - Tob Control. 2012 Jan;21(1):66-72. doi: 10.1136/tobaccocontrol-2011-050201. Epub 
      2011 Sep 26.


PMID- 21948651
OWN - NLM
STAT- MEDLINE
DCOM- 20120426
LR  - 20211020
IS  - 1549-490X (Electronic)
IS  - 1083-7159 (Linking)
VI  - 16
IP  - 10
DP  - 2011
TI  - Discontinuing bevacizumab in patients with glioblastoma: an ethical analysis.
PG  - 1435-9
LID - 10.1634/theoncologist.2011-0047 [doi]
AB  - Glioblastoma (GBM) is a highly lethal malignant brain tumor that expresses
      proangiogenic factors, including vascular endothelial growth factor (VEGF).
      Bevacizumab (Avastin(R); Genentech, Inc., South San Francisco, CA), a monoclonal 
      antibody against VEGF, is routinely used in the U.S. to treat GBM patients whose 
      tumors have progressed following initial therapy. The Ethics Advisory Committee
      at the Dana-Farber Cancer Institute was asked to provide consultation on two
      cases involving patients with recurrent GBM who were receiving bevacizumab.
      Despite evidence of disease progression, family members advocated for the
      continued use of bevacizumab because of its mild toxicity profile and concern
      that discontinuation would impair quality of life. However, continuing
      bevacizumab in this setting posed physical and financial risks to the patients
      and raised ethical concerns about resource allocation and justice. We analyze the
      ethical questions regarding bevacizumab discontinuation in the setting of
      progressive GBM. We articulate the potential benefits and harms of continuing the
      drug and identify guiding principles for drug discontinuation that should be made
      transparent to patients and families. With the increasing availability of new,
      modestly toxic, expensive drugs for patients with advanced cancer, questions of
      when to stop these drugs will become increasingly relevant.
FAU - Kesselheim, Jennifer C
AU  - Kesselheim JC
AD  - Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston,
      Massachusetts 02215, USA. Jennifer_kesselheim@dfci.harvard.edu
FAU - Norden, Andrew D
AU  - Norden AD
FAU - Wen, Patrick Y
AU  - Wen PY
FAU - Joffe, Steven
AU  - Joffe S
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110923
PL  - England
TA  - Oncologist
JT  - The oncologist
JID - 9607837
RN  - 0 (Antibodies, Monoclonal, Humanized)
RN  - 2S9ZZM9Q9V (Bevacizumab)
SB  - IM
MH  - Adult
MH  - Aged, 80 and over
MH  - Antibodies, Monoclonal, Humanized/administration & dosage/*adverse effects
MH  - Antineoplastic Combined Chemotherapy Protocols/*adverse effects/therapeutic use
MH  - Bevacizumab
MH  - Brain Neoplasms/*drug therapy
MH  - *Ethical Analysis
MH  - *Ethics, Medical
MH  - Female
MH  - Glioblastoma/*drug therapy
MH  - Humans
MH  - Male
PMC - PMC3228073
EDAT- 2011/09/29 06:00
MHDA- 2012/04/27 06:00
CRDT- 2011/09/28 06:00
PHST- 2011/09/28 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/04/27 06:00 [medline]
AID - theoncologist.2011-0047 [pii]
AID - 10.1634/theoncologist.2011-0047 [doi]
PST - ppublish
SO  - Oncologist. 2011;16(10):1435-9. doi: 10.1634/theoncologist.2011-0047. Epub 2011
      Sep 23.


PMID- 21948241
OWN - NLM
STAT- MEDLINE
DCOM- 20131126
LR  - 20130304
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 1
DP  - 2013 Mar
TI  - Sustaining engineering codes of ethics for the twenty-first century.
PG  - 237-58
LID - 10.1007/s11948-011-9310-2 [doi]
AB  - How much responsibility ought a professional engineer to have with regard to
      supporting basic principles of sustainable development? While within the United
      States, professional engineering societies, as reflected in their codes of
      ethics, differ in their responses to this question, none of these professional
      societies has yet to put the engineer's responsibility toward sustainability on a
      par with commitments to public safety, health, and welfare. In this paper, we aim
      to suggest that sustainability should be included in the paramountcy clause
      because it is a necessary condition to ensure the safety, health, and welfare of 
      the public. Part of our justification rests on the fact that to engineer
      sustainably means among many things to consider social justice, understood as the
      fair and equitable distribution of social goods, as a design constraint similar
      to technical, economic, and environmental constraints. This element of social
      justice is not explicit in the current paramountcy clause. Our argument rests on 
      demonstrating that social justice in terms of both inter- and intra-generational 
      equity is an important dimension of sustainability (and engineering). We also
      propose that embracing sustainability in the codes while recognizing the role
      that social justice plays may elevate the status of the engineer as public
      intellectual and agent of social good. This shift will then need to be
      incorporated in how we teach undergraduate engineering students about engineering
      ethics.
FAU - Michelfelder, Diane
AU  - Michelfelder D
AD  - Department of Philosophy, Macalester College, St. Paul, MN 55105, USA.
      michelfelder@macalester.edu
FAU - Jones, Sharon A
AU  - Jones SA
LA  - eng
PT  - Journal Article
DEP - 20110923
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Codes of Ethics
MH  - *Conservation of Natural Resources
MH  - Engineering/*ethics
MH  - *Ethics, Professional
MH  - Health
MH  - Humans
MH  - Safety
MH  - *Social Justice
MH  - *Social Responsibility
MH  - Social Welfare
EDAT- 2011/09/29 06:00
MHDA- 2013/12/16 06:00
CRDT- 2011/09/28 06:00
PHST- 2011/04/07 00:00 [received]
PHST- 2011/09/06 00:00 [accepted]
PHST- 2011/09/28 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1007/s11948-011-9310-2 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Mar;19(1):237-58. doi: 10.1007/s11948-011-9310-2. Epub 2011 
      Sep 23.


PMID- 21948226
OWN - NLM
STAT- MEDLINE
DCOM- 20120522
LR  - 20211020
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 23
IP  - 4
DP  - 2011 Dec
TI  - Ethics consultation and empathy : finding the balance in clinical settings.
PG  - 247-55
LID - 10.1007/s10730-011-9164-7 [doi]
AB  - There is no doubt that emotions have an important effect on practices of moral
      reasoning such as clinical ethics consultation. Empathy is not only a basic human
      emotion but also an important and learnable skill for health care professionals. 
      A basic amount of empathy is essential both in patient care and in clinical
      ethics consultation. This article debates the "adequate dose" of empathy in
      ethics consultations in clinical settings and tries to identify possible
      situations within the process of consultation in which this crucial feeling is at
      risk.
FAU - Bruns, Florian
AU  - Bruns F
AD  - Institute for History of Medicine and Medical Ethics,
      Friedrich-Alexander-University Erlangen-Nuremberg, Germany.
FAU - Frewer, Andreas
AU  - Frewer A
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - *Empathy
MH  - *Ethics Committees, Clinical
MH  - *Ethics Consultation
MH  - Humans
EDAT- 2011/09/29 06:00
MHDA- 2012/05/23 06:00
CRDT- 2011/09/28 06:00
PHST- 2011/09/28 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/05/23 06:00 [medline]
AID - 10.1007/s10730-011-9164-7 [doi]
PST - ppublish
SO  - HEC Forum. 2011 Dec;23(4):247-55. doi: 10.1007/s10730-011-9164-7.


PMID- 21947811
OWN - NLM
STAT- MEDLINE
DCOM- 20120501
LR  - 20120123
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 2
DP  - 2012 Feb
TI  - Through students' eyes: ethical and professional issues identified by third-year 
      medical students during clerkships.
PG  - 130-2
LID - 10.1136/medethics-2011-100033 [doi]
AB  - BACKGROUND: Education in ethics and professionalism should reflect the realities 
      medical students encounter in the hospital and clinic. METHOD: We performed
      content analyses on Case Observation and Assessments (COAs) written by third-year
      medical students about ethical and professional issues encountered during their
      internal medicine and paediatrics clinical clerkships. RESULTS: A cohort of 141
      third-year medical students wrote 272 COAs. Content analyses identified 35
      subcategories of ethical and professional issues within 7 major domains:
      decisions regarding treatment (31.4%), communication (21.4%), professional duties
      (18.4%), justice (9.8%), student-specific issues (5.4%), quality of care (3.8%), 
      and miscellaneous (9.8%). CONCLUSIONS: Students encountered a wide variety of
      ethical and professional issues that can be used to guide pre-clinical and
      clinical education. Comparison of our findings with results from similar studies 
      suggests that the wording of an assignment (specifying "ethical" issues,
      "professional" issues, or both) may influence the kinds of issues students
      identify in their experience-based clinical narratives.
FAU - Kaldjian, Lauris C
AU  - Kaldjian LC
AD  - Department of Internal Medicine, University of Iowa Carver College of Medicine,
      500 Newton Road, Iowa City, IA 52242, USA. lauris-kaldjian@uiowa.edu
FAU - Rosenbaum, Marcy E
AU  - Rosenbaum ME
FAU - Shinkunas, Laura A
AU  - Shinkunas LA
FAU - Woodhead, Jerold C
AU  - Woodhead JC
FAU - Antes, Lisa M
AU  - Antes LM
FAU - Rowat, Jane A
AU  - Rowat JA
FAU - Forman-Hoffman, Valerie L
AU  - Forman-Hoffman VL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110924
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Clinical Clerkship/ethics
MH  - Cohort Studies
MH  - Curriculum
MH  - Education, Medical, Undergraduate/standards
MH  - Ethics, Medical/*education
MH  - Humans
MH  - Internal Medicine/education
MH  - Professional Competence/*standards
MH  - Students, Medical
EDAT- 2011/09/29 06:00
MHDA- 2012/05/02 06:00
CRDT- 2011/09/28 06:00
PHST- 2011/09/28 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/05/02 06:00 [medline]
AID - medethics-2011-100033 [pii]
AID - 10.1136/medethics-2011-100033 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Feb;38(2):130-2. doi: 10.1136/medethics-2011-100033. Epub 2011
      Sep 24.


PMID- 21947810
OWN - NLM
STAT- MEDLINE
DCOM- 20121031
LR  - 20120523
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 6
DP  - 2012 Jun
TI  - The case of biobank with the law: between a legal and scientific fiction.
PG  - 347-50
LID - 10.1136/jme.2010.041632 [doi]
AB  - According to estimates more than 400 biobanks currently operate across Europe.
      The term 'biobank' indicates a specific field of genetic study that has quietly
      developed without any significant critical reflection across European societies. 
      Although scientists now routinely use this phrase, the wider public is still
      confused when the word 'bank' is being connected with the collection of their
      biological samples. There is a striking lack of knowledge of this field. In the
      recent Eurobarometer survey it was demonstrated that even in 2010 two-thirds of
      the respondents had never even heard about biobanks. The term gives the
      impression that a systematic collection of biological samples can constitute a
      'bank' of considerable financial worth, where the biological samples, which are
      insignificant in isolation but are valuable as a collection, can be preserved,
      analysed and put to 'profitable use'. By studying the practices of the numerous
      already existing biobanks, the authors address the following questions: to what
      extent does the term 'biobank' reflect the normative concept of using biological 
      samples for the purposes of biomedical research? Furthermore, is it in harmony
      with the so far agreed legal-ethical consensus in Europe or does it deliberately 
      pull science to the territory of a new, ambiguous commercial field? In other
      words, do biobanks constitute a medico-legal fiction or are they substantively
      different from other biomedical research protocols on human tissues?
FAU - Sandor, Judit
AU  - Sandor J
AD  - Center for Ethics and Law in Biomedicine, Central European University Budapest,
      Budapest, Hungary. sandorj@ceu.hu
FAU - Bard, Petra
AU  - Bard P
FAU - Tamburrini, Claudio
AU  - Tamburrini C
FAU - Tannsjo, Torbjorn
AU  - Tannsjo T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110924
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Biological Specimen Banks/ethics/*legislation & jurisprudence/organization &
      administration
MH  - Biomedical Research/ethics/*legislation & jurisprudence
MH  - Europe
MH  - Humans
MH  - Specimen Handling/methods
MH  - Tissue Donors/ethics/*legislation & jurisprudence
EDAT- 2011/09/29 06:00
MHDA- 2012/11/01 06:00
CRDT- 2011/09/28 06:00
PHST- 2011/09/28 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/11/01 06:00 [medline]
AID - jme.2010.041632 [pii]
AID - 10.1136/jme.2010.041632 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Jun;38(6):347-50. doi: 10.1136/jme.2010.041632. Epub 2011 Sep 
      24.


PMID- 21947805
OWN - NLM
STAT- MEDLINE
DCOM- 20120524
LR  - 20120220
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 3
DP  - 2012 Mar
TI  - A fair share for the orphans: ethical guidelines for a fair distribution of
      resources within the bounds of the 10-year-old European Orphan Drug Regulation.
PG  - 148-53
LID - 10.1136/medethics-2011-100094 [doi]
AB  - For a significant number of patients, there exists no, or only little, interest
      in developing a treatment for their disease or condition. Especially with regard 
      to rare diseases, the lack of commercial interest in drug development is a
      burning issue. Several interventions have been made in the regulatory field in
      order to address the commercial disinterest in these conditions. However,
      existing regulations mainly focus on the provision of incentives to the sponsors 
      of clinical trials of orphan drugs, and leave unanswered the overarching question
      about the rightful place of orphan drugs in resource allocation systems. In this 
      article, we analyse the ethical aspects of funding research and development in
      the field of rare diseases. We then propose an ethical framework that can help
      health policy makers move forward in the difficult matter of fairly allocating
      resources for the prevention, diagnosis and treatment of rare diseases.
FAU - Pinxten, Wim
AU  - Pinxten W
AD  - Centre for Biomedical Ethics and Law, Faculty of Medicine, KU Leuven,
      Kapucijnenvoer 35, Leuven, Belgium.
FAU - Denier, Yvonne
AU  - Denier Y
FAU - Dooms, Marc
AU  - Dooms M
FAU - Cassiman, Jean-Jacques
AU  - Cassiman JJ
FAU - Dierickx, Kris
AU  - Dierickx K
LA  - eng
PT  - Journal Article
DEP - 20110924
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Bioethics
MH  - *Ethics, Medical
MH  - Europe/epidemiology
MH  - Guidelines as Topic
MH  - Health Policy/economics/legislation & jurisprudence
MH  - Health Services Accessibility/organization & administration
MH  - Humans
MH  - Morals
MH  - Orphan Drug Production/*economics/*legislation & jurisprudence
MH  - Rare Diseases/drug therapy/economics
MH  - Research/economics
MH  - Research Support as Topic
MH  - Resource Allocation/*organization & administration
EDAT- 2011/09/29 06:00
MHDA- 2012/05/25 06:00
CRDT- 2011/09/28 06:00
PHST- 2011/09/28 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/05/25 06:00 [medline]
AID - medethics-2011-100094 [pii]
AID - 10.1136/medethics-2011-100094 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Mar;38(3):148-53. doi: 10.1136/medethics-2011-100094. Epub
      2011 Sep 24.


PMID- 21947804
OWN - NLM
STAT- MEDLINE
DCOM- 20120524
LR  - 20140325
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 3
DP  - 2012 Mar
TI  - Is medical students' moral orientation changeable after preclinical medical
      education?
PG  - 168-73
LID - 10.1136/medethics-2011-100092 [doi]
AB  - PURPOSE: Moral orientation can affect ethical decision-making. Very few studies
      have focused on whether medical education can change the moral orientation of the
      students. The purpose of the present study was to document the types of moral
      orientation exhibited by medical students, and to study if their moral
      orientation was changed after preclinical education. METHODS: From 2007 to 2009, 
      the Mojac scale was used to measure the moral orientation of Taiwan medical
      students. The students included 271 first-year and 109 third-year students. They 
      were rated as a communitarian, dual, or libertarian group and followed for 2
      years to monitor the changes in their Mojac scores. RESULTS: In both first and
      third-year students, the dual group after 2 years of preclinical medical
      education did not show any significant change. In the libertarian group, first
      and third-year students showed a statistically significant increase from a score 
      of 99.4 and 101.3 to 103.0 and 105.7, respectively. In the communitarian group,
      first and third-year students showed a significant decline from 122.8 and 126.1
      to 116.0 and 121.5, respectively. CONCLUSION: During the preclinical medical
      education years, students with communitarian orientation and libertarian
      orientation had changed in their moral orientation to become closer to dual
      orientation. These findings provide valuable hints to medical educators regarding
      bioethics education and the selection criteria of medical students for admission.
FAU - Lin, Chaou-Shune
AU  - Lin CS
AD  - College of Medicine, Fu-Jen Catholic University, No. 510 Chung-Cheng Road,
      Hsin-Chuang District, New Taipei City, Taiwan, ROC. 049687@mail.fju.edu.tw
FAU - Tsou, Kuo-Inn
AU  - Tsou KI
FAU - Cho, Shu-Ling
AU  - Cho SL
FAU - Hsieh, Ming-Shium
AU  - Hsieh MS
FAU - Wu, Hsi-Chin
AU  - Wu HC
FAU - Lin, Chyi-Her
AU  - Lin CH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110924
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cohort Studies
MH  - Education, Medical, Undergraduate/methods
MH  - Ethics, Medical/*education
MH  - Female
MH  - Freedom
MH  - Humans
MH  - Male
MH  - *Moral Development
MH  - Psychological Theory
MH  - Social Responsibility
MH  - Students, Medical/*psychology
MH  - Taiwan
MH  - Young Adult
EDAT- 2011/09/29 06:00
MHDA- 2012/05/25 06:00
CRDT- 2011/09/28 06:00
PHST- 2011/09/28 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/05/25 06:00 [medline]
AID - medethics-2011-100092 [pii]
AID - 10.1136/medethics-2011-100092 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Mar;38(3):168-73. doi: 10.1136/medethics-2011-100092. Epub
      2011 Sep 24.


PMID- 21947803
OWN - NLM
STAT- MEDLINE
DCOM- 20120312
LR  - 20111122
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 12
DP  - 2011 Dec
TI  - Neurotrauma and the rule of rescue.
PG  - 707-10
LID - 10.1136/medethics-2011-100081 [doi]
AB  - The rule of rescue describes the powerful human proclivity to rescue identified
      endangered lives, regardless of cost or risk. Deciding whether or not to perform 
      a decompressive craniectomy as a life-saving or 'rescue' procedure for a young
      person with a severe traumatic brain injury provides a good example of the
      ethical tensions that occur in these situations. Unfortunately, there comes a
      point when the primary brain injury is so severe that if the patient survives
      they are likely to remain severely disabled and fully dependent. The health
      resource implications of this outcome are significant. By using a web-based
      outcome prediction model this study compares the long-term outcome and
      designation of two groups of patients. One group had a very severe injury as
      adjudged by the model and the other group a less severe injury. At 18 month
      follow-up there were significant differences in outcome and healthcare
      requirements. This raises important ethical issues when considering life-saving
      but non-restorative surgical intervention. The discussion about realistic outcome
      cannot be dichotomised into simply life or death so that the outcome for the
      patient must enter the equation. As in other 'rescue situations', the utility of 
      the procedure cannot be rationalised on a mere cost-benefit analysis. A
      compromise has to be reached to determine at what point either the likely outcome
      would be unacceptable to the person on whom the procedure is being performed or
      the social utility gained from the rule of rescue intervention fails to justify
      the utilitarian value and justice of equitable resource allocation.
FAU - Honeybul, S
AU  - Honeybul S
AD  - Department of Neurosurgery, Sir Charles Gairdner Hospital, Perth, WA, Australia. 
      stephen.honeybul@health.wa.gov.au
FAU - Gillett, G R
AU  - Gillett GR
FAU - Ho, K M
AU  - Ho KM
FAU - Lind, C R P
AU  - Lind CR
LA  - eng
PT  - Journal Article
DEP - 20110924
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Brain Injuries/*surgery
MH  - Cohort Studies
MH  - Cost-Benefit Analysis
MH  - Decision Making/ethics
MH  - Decompressive Craniectomy/adverse effects/economics/*ethics
MH  - Ethical Theory
MH  - *Ethics, Clinical
MH  - Follow-Up Studies
MH  - Humans
MH  - Prognosis
MH  - Rescue Work/*economics/*ethics
MH  - Resource Allocation/economics/ethics
MH  - Treatment Outcome
EDAT- 2011/09/29 06:00
MHDA- 2012/03/13 06:00
CRDT- 2011/09/28 06:00
PHST- 2011/09/28 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/03/13 06:00 [medline]
AID - medethics-2011-100081 [pii]
AID - 10.1136/medethics-2011-100081 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Dec;37(12):707-10. doi: 10.1136/medethics-2011-100081. Epub
      2011 Sep 24.


PMID- 21947802
OWN - NLM
STAT- MEDLINE
DCOM- 20120312
LR  - 20220129
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 12
DP  - 2011 Dec
TI  - Ethical practice in internet research involving vulnerable people: lessons from a
      self-harm discussion forum study (SharpTalk).
PG  - 752-8
LID - 10.1136/medethics-2011-100080 [doi]
AB  - The internet is widely used for health information and support, often by
      vulnerable people. Internet-based research raises both familiar and new ethical
      problems for researchers and ethics committees. While guidelines for
      internet-based research are available, it is unclear to what extent ethics
      committees use these. Experience of gaining research ethics approval for a UK
      study (SharpTalk), involving internet-based discussion groups with young people
      who self-harm and health professionals is described. During ethical review,
      unsurprisingly, concerns were raised about the vulnerability of potential
      participants. These were dominated by the issue of anonymity, which also affected
      participant safety and consent. These ethical problems are discussed, and our
      solutions, which included: participant usernames specific to the study, a closed 
      website, private messaging facilities, a direct contact email to researchers,
      information about forum rules displayed on the website, a 'report' button for
      participants, links to online support, and a discussion room for forum
      moderators. This experience with SharpTalk suggests that an approach to ethics,
      which recognises the relational aspects of research with vulnerable people, is
      particularly useful for internet-based health research. The solutions presented
      here can act as guidance for researchers developing proposals and for ethics
      committees reviewing them.
FAU - Sharkey, Siobhan
AU  - Sharkey S
AD  - Peninsula Medical School, University of Exeter, Exeter, UK.
      siobhan.sharkey@pms.ac.uk
FAU - Jones, Ray
AU  - Jones R
FAU - Smithson, Janet
AU  - Smithson J
FAU - Hewis, Elaine
AU  - Hewis E
FAU - Emmens, Tobit
AU  - Emmens T
FAU - Ford, Tamsin
AU  - Ford T
FAU - Owens, Christabel
AU  - Owens C
LA  - eng
GR  - G108/625/MRC_/Medical Research Council/United Kingdom
GR  - RC-PG-0407-10098/DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110924
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Confidentiality
MH  - Ethics Committees, Research/ethics
MH  - *Ethics, Research
MH  - Humans
MH  - Informed Consent/ethics
MH  - Internet/*ethics
MH  - Morals
MH  - Patient Safety
MH  - Self-Injurious Behavior/*prevention & control
MH  - Vulnerable Populations/legislation & jurisprudence
EDAT- 2011/09/29 06:00
MHDA- 2012/03/13 06:00
CRDT- 2011/09/28 06:00
PHST- 2011/09/28 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/03/13 06:00 [medline]
AID - medethics-2011-100080 [pii]
AID - 10.1136/medethics-2011-100080 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Dec;37(12):752-8. doi: 10.1136/medethics-2011-100080. Epub
      2011 Sep 24.


PMID- 21947800
OWN - NLM
STAT- MEDLINE
DCOM- 20120524
LR  - 20120220
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 3
DP  - 2012 Mar
TI  - The role of the principle of double effect in ethics education at US medical
      schools and its potential impact on pain management at the end of life.
PG  - 174-8
LID - 10.1136/medethics-2011-100105 [doi]
AB  - BACKGROUND: Because opioids can suppress respiratory drive, the principle of
      double effect (PDE) has been used to justify their use for terminally ill
      patients. Recent studies, however, suggest that the risk of respiratory
      depression in typical end-of-life (EOL) situations may be overstated and that
      heightened concern for this rare occurrence can lead to inadequate treatment of
      pain. The purpose of this study is to examine the role of the PDE in medical
      school ethics education, with specific reference to its potential impact on pain 
      management at EOL. METHOD: After obtaining institutional review board approval,
      an electronic survey was sent to ethics educators at every allopathic medical
      school in the USA. RESULTS: One-third of ethics educators felt that opioids were 
      'likely' to cause significant respiratory depression that could hasten death.
      Educators' opinions of opioid effects did not influence their view of the
      relevance of the PDE, with approximately 70% deeming it relevant to EOL care.
      Only 15% of ethics educators believed that associating the PDE with opioid use
      might discourage clinicians from optimally treating pain, out of concern for
      respiratory depression. CONCLUSION: This study demonstrates that a significant
      minority of ethics educators believe, contrary to current evidence, that opioids 
      are 'likely' to cause significant respiratory depression that could hasten death 
      in terminally ill patients. Yet, many of those who do not feel this is likely
      still rely on the PDE to justify this possibility, potentially (and unknowingly) 
      contributing to clinical misperceptions and underutilisation of opioids at EOL.
FAU - Macauley, Robert
AU  - Macauley R
AD  - Department of Clinical Ethics, Fletcher Allen Health Care, 111 Colchester Avenue,
      Burlington, Vermont 05401, USA. robert.macauley@uvm.edu
LA  - eng
PT  - Journal Article
DEP - 20110924
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
RN  - 0 (Analgesics, Opioid)
SB  - IM
MH  - Analgesics, Opioid/*adverse effects/*therapeutic use
MH  - Double Effect Principle
MH  - Education, Medical
MH  - *Ethics, Medical
MH  - Humans
MH  - Pain Management/*ethics/methods
MH  - Respiratory Insufficiency/*chemically induced
MH  - Schools, Medical
MH  - Terminal Care/*ethics
MH  - United States
EDAT- 2011/09/29 06:00
MHDA- 2012/05/25 06:00
CRDT- 2011/09/28 06:00
PHST- 2011/09/28 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/05/25 06:00 [medline]
AID - medethics-2011-100105 [pii]
AID - 10.1136/medethics-2011-100105 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Mar;38(3):174-8. doi: 10.1136/medethics-2011-100105. Epub 2011
      Sep 24.


PMID- 21947407
OWN - NLM
STAT- MEDLINE
DCOM- 20121205
LR  - 20211020
IS  - 1439-6327 (Electronic)
IS  - 1439-6319 (Linking)
VI  - 112
IP  - 6
DP  - 2012 Jun
TI  - The role of aerobic fitness and exercise intensity on endurance performance in
      uncompensable heat stress conditions.
PG  - 1989-99
LID - 10.1007/s00421-011-2165-z [doi]
AB  - The aim of this study was to examine the influence of aerobic fitness and
      exercise intensity on the development of thermal and cardiovascular strain in
      uncompensable heat stress conditions. In three separate trials, eight aerobically
      trained and eight untrained subjects cycled to exhaustion at 60% (H60%) and 75%
      (H75%) of maximal oxygen uptake [Formula: see text] in 40 degrees C conditions,
      and for 60 min at 60% [Formula: see text] in 18 degrees C conditions (CON).
      Training status had no influence on time to exhaustion between trained (61 +/- 10
      and 31 +/- 9 min) and untrained (58 +/- 12 and 26 +/- 10 min) subjects (H60% and 
      H75%, respectively). Rectal temperature at exhaustion was also not significantly 
      different between trained (39.8 +/- 0.3, 39.3 +/- 0.6 and 38.2 +/- 0.3 degrees C)
      and untrained (39.4 +/- 0.5, 38.8 +/- 0.5 and 38.2 +/- 0.4 degrees C) subjects,
      but was different between trials (H60%, H75% and CON, respectively; P < 0.01).
      However, because exercise was terminated on reaching the ethics approved rectal
      temperature limit in four trained subjects in the H60% trial and two in the H75% 
      trial, it is speculated that increased rectal temperature may have further
      occurred in this cohort. Nonetheless, exhaustion occurred >96% of maximum heart
      rate in both cohorts and was accompanied by significant declines in stroke volume
      (15-26%), cardiac output (5-10%) and mean arterial pressure (9-13%) (P < 0.05).
      The increase in cardiovascular strain appears to represent the foremost factor
      precipitating fatigue during moderate and high intensity aerobic exercise in the 
      heat in both trained and untrained subjects.
FAU - Periard, Julien D
AU  - Periard JD
AD  - Aspetar, Research and Education Centre, Qatar Orthopaedic and Sports Medicine
      Hospital, PO Box 29222, Doha, Qatar. julien.periard@aspetar.com
FAU - Caillaud, Corinne
AU  - Caillaud C
FAU - Thompson, Martin W
AU  - Thompson MW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110923
PL  - Germany
TA  - Eur J Appl Physiol
JT  - European journal of applied physiology
JID - 100954790
SB  - IM
MH  - Adult
MH  - Blood Pressure/physiology
MH  - Body Temperature/physiology
MH  - Body Temperature Regulation/*physiology
MH  - Cardiac Output/physiology
MH  - Cohort Studies
MH  - Exercise/*physiology
MH  - Fatigue/physiopathology
MH  - Heart Rate/physiology
MH  - Heat-Shock Response/genetics/*physiology
MH  - Hot Temperature
MH  - Humans
MH  - Male
MH  - Oxygen Consumption/physiology
MH  - Physical Endurance/*physiology
MH  - Physical Fitness/*physiology
MH  - Stroke Volume/physiology
EDAT- 2011/09/29 06:00
MHDA- 2012/12/10 06:00
CRDT- 2011/09/28 06:00
PHST- 2011/05/10 00:00 [received]
PHST- 2011/09/02 00:00 [accepted]
PHST- 2011/09/28 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1007/s00421-011-2165-z [doi]
PST - ppublish
SO  - Eur J Appl Physiol. 2012 Jun;112(6):1989-99. doi: 10.1007/s00421-011-2165-z. Epub
      2011 Sep 23.


PMID- 21946640
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20110929
IS  - 1175-8716 (Electronic)
IS  - 0028-8446 (Linking)
VI  - 124
IP  - 1334
DP  - 2011 May 13
TI  - Mind the Gap: ethical issues of private treatment in the public health system.
PG  - 89-96
AB  - The funding of expensive new cancer treatments is a difficult health policy issue
      in New Zealand and around the world. Since the public health system cannot afford
      to fund every new treatment, complex decisions must be made about which
      treatments to fund publicly, and whether and how to make unfunded treatments
      available to people who may wish to fund them themselves. One recent proposal is 
      that unfunded treatments be made available to patients privately through the
      local public hospital. Although ultimately declined by the health minister, this 
      proposal merits serious debate, since it is likely to continue to attract
      attention as a policy option. While the integration of public and private
      delivery systems has clear benefits for patients with the means to purchase
      additional treatments, its overall effect may be to exacerbate existing
      inequities in the New Zealand health sector. This paper briefly explores the
      wider ramifications of such schemes as part of the ongoing public discussion that
      should inform the development of health policy on this issue.
CI  - (c)NZMA
FAU - Fenton, Elizabeth
AU  - Fenton E
AD  - Institute for Practical Ethics and Public Life, University of Virginia, PO Box
      400800, Charlottesville VA 22904, USA. emf7u@virginia.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110513
PL  - New Zealand
TA  - N Z Med J
JT  - The New Zealand medical journal
JID - 0401067
SB  - IM
CIN - N Z Med J. 2011 May 13;124(1334):8-10. PMID: 21946629
MH  - Health Care Costs
MH  - Health Policy
MH  - Health Services Accessibility/ethics
MH  - Healthcare Disparities
MH  - Humans
MH  - Neoplasms/economics/*therapy
MH  - New Zealand
MH  - *Private Sector
MH  - *Public Sector
EDAT- 2011/09/29 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/09/28 06:00
PHST- 2011/09/28 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PST - epublish
SO  - N Z Med J. 2011 May 13;124(1334):89-96.


PMID- 21946594
OWN - NLM
STAT- MEDLINE
DCOM- 20111102
LR  - 20151119
IS  - 0807-7096 (Electronic)
IS  - 0029-2001 (Linking)
VI  - 131
IP  - 18
DP  - 2011 Sep 20
TI  - [Attitudes of medical students towards abortion].
PG  - 1768-71
LID - 10.4045/tidsskr.10.1161 [doi]
AB  - BACKGROUND: It is not known whether the attitudes of Norwegian medical students
      towards abortion change in the course of their studies, or whether the attitudes 
      differ among the four Norwegian medical schools. We have investigated attitudes
      towards abortion and the right to conscientious objection among medical students 
      early and late in their studies at the four medical schools. Student satisfaction
      with the teaching on abortion was also surveyed. MATERIAL AND METHODS: A
      questionnaire survey was carried out among medical students at the four Norwegian
      medical schools, first year and fourth/fifth year students respectively. RESULTS:
      514 students (58.3 % of the students in the chosen classes) responded. 87.5 %
      approved of abortion on demand. The students at NTNU were the most liberal (93.5 
      %). Fourth/fifth year students were more liberal than first year students (91.3 %
      vs. 84.7 %, p = 0.027). 27.3 % would want to exercise their right to
      conscientious objection. 41.5 % had been present at a surgical abortion. Of those
      who had not been present at a surgical abortion, 84.1 % would want to see an
      abortion being carried out if given the opportunity. 29 % agreed that the
      teaching did not adequately cover the ethical aspects of abortion.
      INTERPRETATION: Abortion on demand has wide approval among Norwegian medical
      students. However, many students would consider exercising their right to
      conscientious objection. More fourth/fifth year students than first year students
      approved of abortion.
FAU - Hagen, Gunn Helen
AU  - Hagen GH
AD  - Senter for medisinsk etikk, Universitetet i Oslo, Norway.
      g.h.hagen@studmed.uio.no
FAU - Hage, Christine Odegaard
AU  - Hage CO
FAU - Magelssen, Morten
AU  - Magelssen M
FAU - Nortvedt, Per
AU  - Nortvedt P
LA  - nor
PT  - English Abstract
PT  - Journal Article
TT  - Medisinstudenters holdninger til selvbestemt abort.
PL  - Norway
TA  - Tidsskr Nor Laegeforen
JT  - Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny
      raekke
JID - 0413423
SB  - IM
MH  - Abortion, Induced/education/*psychology
MH  - Attitude of Health Personnel
MH  - Female
MH  - Humans
MH  - Male
MH  - Norway
MH  - Pregnancy
MH  - Students, Medical/*psychology
MH  - Surveys and Questionnaires
EDAT- 2011/09/29 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/09/28 06:00
PHST- 2011/09/28 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
AID - 2140083 [pii]
AID - 10.4045/tidsskr.10.1161 [doi]
PST - ppublish
SO  - Tidsskr Nor Laegeforen. 2011 Sep 20;131(18):1768-71. doi:
      10.4045/tidsskr.10.1161.


PMID- 21945675
OWN - NLM
STAT- MEDLINE
DCOM- 20120607
LR  - 20220317
IS  - 1526-3231 (Electronic)
IS  - 0749-8063 (Linking)
VI  - 27
IP  - 12
DP  - 2011 Dec
TI  - Influence of testing conditions on primary stability of arthroscopic knot tying
      for rotator cuff repair: slippery when wet?
PG  - 1628-36
LID - 10.1016/j.arthro.2011.06.031 [doi]
AB  - PURPOSE: The purpose was to evaluate whether the knot security of sliding and
      nonsliding knots with different sutures is influenced by dry or wet conditions.
      METHODS: We tested 5 suture materials, all of them US Pharmacopeia No. 2: PDS
      (polydioxanone) II (Ethicon, Somerville, NJ), Ethibond (Ethicon), and 3
      ultrahigh-molecular weight polyethylene (UHMWPE) sutures-FiberWire (Arthrex,
      Naples, FL), Orthocord (DePuy Mitek, Raynham, MA), and Herculine (Linvatec,
      Largo, FL). Testing was performed under dry and wet conditions with sutures
      soaked in a saline solution. Cyclic loading was performed to simulate physiologic
      conditions. We started with a tensile load of 25 N. After 100 cycles, the load
      was increased to 50 N for another 100 cycles. The tensile load was gradually
      increased by 25 N per 100 cycles until suture rupture or knot slippage, defined
      as lengthening over 3 mm. RESULTS: Under dry conditions, 170 suture ruptures and 
      30 knot slippages were reported; and under wet testing conditions, 186 suture
      ruptures and 14 knot slippages were reported, with P < .044 and P < .027,
      respectively. Failure by knot slippage (n = 44) was seen under dry and saline
      solution conditions mainly with UHMWPE sutures, in particular with the Herculine 
      suture using a Roeder knot showing comparable maximum failure loads in dry (274.5
      +/- 58.2 N) and saline solution (312.5 +/- 14.2 N) conditions (P > .056). Knot
      slippage occurred only with sliding knots. With the Ethibond suture, no knot
      slippage was found regardless of the testing conditions and knot type. Across all
      knot types, the UHMWPE sutures were significantly stronger with respect to
      clinical and maximum failure loads in ultimate load to failure than Ethibond and 
      PDS II under dry and wet testing conditions (P < .001 for both). CONCLUSIONS: We 
      conclude that testing of different suture materials and knot types is different
      in wet versus dry conditions and believe that biomechanical testing might be more
      realistic in a wet environment. CLINICAL RELEVANCE: Suture knots behave
      differently in a wet versus dry environment, and testing of knot mechanics might 
      better be carried out in wet environments.
CI  - Copyright (c) 2011 Arthroscopy Association of North America. Published by
      Elsevier Inc. All rights reserved.
FAU - Pietschmann, Matthias F
AU  - Pietschmann MF
AD  - Department of Orthopaedic Surgery, Ludwig-Maximilians-University Munich, Campus
      Grosshadern, Germany.
FAU - Sadoghi, Patrick
AU  - Sadoghi P
FAU - Hauser, Eva
AU  - Hauser E
FAU - Scharpf, Andreas
AU  - Scharpf A
FAU - Gulecyuz, Mehmet F
AU  - Gulecyuz MF
FAU - Schroder, Christian
AU  - Schroder C
FAU - Jansson, Volkmar
AU  - Jansson V
FAU - Muller, Peter E
AU  - Muller PE
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110925
PL  - United States
TA  - Arthroscopy
JT  - Arthroscopy : the journal of arthroscopic & related surgery : official
      publication of the Arthroscopy Association of North America and the International
      Arthroscopy Association
JID - 8506498
SB  - IM
MH  - Arm Injuries/*surgery
MH  - Arthroscopy/*methods
MH  - Equipment Failure
MH  - Humans
MH  - Materials Testing/*methods
MH  - Rotator Cuff/*surgery
MH  - Rotator Cuff Injuries
MH  - Rupture
MH  - Suture Techniques/*instrumentation
MH  - *Sutures
MH  - Tensile Strength
EDAT- 2011/09/29 06:00
MHDA- 2012/06/08 06:00
CRDT- 2011/09/28 06:00
PHST- 2010/12/01 00:00 [received]
PHST- 2011/06/23 00:00 [revised]
PHST- 2011/06/23 00:00 [accepted]
PHST- 2011/09/28 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/06/08 06:00 [medline]
AID - S0749-8063(11)00620-7 [pii]
AID - 10.1016/j.arthro.2011.06.031 [doi]
PST - ppublish
SO  - Arthroscopy. 2011 Dec;27(12):1628-36. doi: 10.1016/j.arthro.2011.06.031. Epub
      2011 Sep 25.


PMID- 21945358
OWN - NLM
STAT- MEDLINE
DCOM- 20120223
LR  - 20220311
IS  - 1872-6232 (Electronic)
IS  - 0378-3782 (Linking)
VI  - 87
IP  - 11
DP  - 2011 Nov
TI  - Armed conflict women and girls who are pregnant, infants and children; a
      neglected public health challenge. What can health professionals do?
PG  - 735-42
LID - 10.1016/j.earlhumdev.2011.08.020 [doi]
AB  - Without security, adequate healthcare is not possible. Armed conflicts continue
      to be waged with pregnant women and girls, babies and children affected most.
      Most countries in conflict are poorly resourced and their mortality and morbidity
      statistics so much higher than rich countries that nothing short of a global
      revolution to create equity is going to solve the problem. When the arms trade is
      added in and analysed the maternal and child mortality rates for those countries 
      exporting most of these killing machines is so much lower than the countries in
      which they are used that we have an ethical issue that must be addressed by
      health professionals. Armed conflict is probably the most serious global public
      health challenge and two solutions are proposed. Health professionals have a
      major voice and must support the currently progressing Arms Trade Treaty and call
      for more effective protection for healthcare in areas of conflict.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Southall, David
AU  - Southall D
AD  - Maternal and Childhealth Advocacy International-MCAI, 83 Derby Road, Nottingham, 
      United Kingdom. davids@doctors.org.uk
LA  - eng
PT  - Journal Article
DEP - 20110923
PL  - Ireland
TA  - Early Hum Dev
JT  - Early human development
JID - 7708381
SB  - IM
MH  - Child
MH  - Child Mortality
MH  - Delivery of Health Care/*ethics
MH  - Female
MH  - Geography
MH  - Health Personnel/*ethics
MH  - Health Priorities/ethics/legislation & jurisprudence
MH  - Humans
MH  - Infant
MH  - Maternal Mortality
MH  - Poverty
MH  - Pregnancy
MH  - Public Health/ethics
MH  - Rape
MH  - Social Welfare/ethics
MH  - *Warfare
MH  - *Weapons
EDAT- 2011/09/29 06:00
MHDA- 2012/02/24 06:00
CRDT- 2011/09/28 06:00
PHST- 2011/09/28 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/02/24 06:00 [medline]
AID - S0378-3782(11)00280-5 [pii]
AID - 10.1016/j.earlhumdev.2011.08.020 [doi]
PST - ppublish
SO  - Early Hum Dev. 2011 Nov;87(11):735-42. doi: 10.1016/j.earlhumdev.2011.08.020.
      Epub 2011 Sep 23.


PMID- 21945118
OWN - NLM
STAT- MEDLINE
DCOM- 20120515
LR  - 20131121
IS  - 1095-6840 (Electronic)
IS  - 0016-6480 (Linking)
VI  - 174
IP  - 2
DP  - 2011 Nov 1
TI  - Urinary corticosterone responses to capture and toe-clipping in the cane toad
      (Rhinella marina) indicate that toe-clipping is a stressor for amphibians.
PG  - 238-45
LID - 10.1016/j.ygcen.2011.09.004 [doi]
AB  - Toe-clipping, the removal of one or more toes, is a common method used to
      individually mark free-living animals. Whilst this method is widely used in
      studies of amphibians, the appropriateness of the method, and its potential
      detrimental effects have been the subject of debate. Here, we provide for the
      first time, evidence that toe-clipping is a stressor in a wild amphibian. We
      measured urinary corticosterone responses of male cane toads (Rhinella marina) to
      capture and handling only, and to toe-clipping under field conditions. Urinary
      testosterone concentrations and white blood cell proportions were also measured. 
      Urinary corticosterone metabolite concentrations increased 6h after capture and
      handling only and remained high for 24h; corticosterone returned to baseline
      levels after 48 h and remained low at 72 h post capture and handling.
      Corticosterone concentrations in toads subjected to toe-clipping increased at 6h 
      to significantly higher concentrations than after capture and handling only, then
      decreased more slowly than after capture and handling, and were still elevated
      (approximately double basal level) 72 h after toe-clipping. Testosterone did not 
      change significantly after capture and handling only, whereas after toe-clipping 
      testosterone decreased at 6h and remained low at 72 h. There were weak short-term
      effects of toe-clipping compared with capture and handling only on white blood
      cell proportions. We have clearly shown that toe-clipping is a distinctly
      stronger stressor than capture and handling alone. This indicates that there is
      an ethical cost of toe-clipping, and this should be considered when planning
      studies of amphibians.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Narayan, Edward J
AU  - Narayan EJ
AD  - Environmental Futures Centre, School of Environment, Griffith University, Gold
      Coast Campus, QLD 4222, Australia. e.narayan@griffith.edu.au
FAU - Molinia, Frank C
AU  - Molinia FC
FAU - Kindermann, Christina
AU  - Kindermann C
FAU - Cockrem, John F
AU  - Cockrem JF
FAU - Hero, Jean-Marc
AU  - Hero JM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110916
PL  - United States
TA  - Gen Comp Endocrinol
JT  - General and comparative endocrinology
JID - 0370735
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Amphibians
MH  - Animals
MH  - Anura
MH  - Corticosterone/*urine
MH  - Male
MH  - Restraint, Physical
MH  - Stress, Physiological/*physiology
EDAT- 2011/09/29 06:00
MHDA- 2012/05/16 06:00
CRDT- 2011/09/28 06:00
PHST- 2011/04/28 00:00 [received]
PHST- 2011/09/01 00:00 [revised]
PHST- 2011/09/06 00:00 [accepted]
PHST- 2011/09/28 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/05/16 06:00 [medline]
AID - S0016-6480(11)00360-1 [pii]
AID - 10.1016/j.ygcen.2011.09.004 [doi]
PST - ppublish
SO  - Gen Comp Endocrinol. 2011 Nov 1;174(2):238-45. doi: 10.1016/j.ygcen.2011.09.004. 
      Epub 2011 Sep 16.


PMID- 21944570
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20220330
IS  - 1532-3099 (Electronic)
IS  - 0266-6138 (Linking)
VI  - 28
IP  - 4
DP  - 2012 Aug
TI  - Deciding to join a perinatal randomised controlled trial: experiences and views
      of pregnant women enroled in the Magpie Trial.
PG  - E478-85
LID - 10.1016/j.midw.2011.08.006 [doi]
AB  - OBJECTIVE: to provide insight into pregnant women's experiences of participating 
      in a large multi-centre randomised trial. DESIGN: qualitative semi-structured
      interviews. SETTING: six UK maternity units. PARTICIPANTS: women recruited to the
      Magpie Trial. The Magpie Trial was a trial of prophylactic anticonvulsants for
      women with severe pre-eclampsia. MEASUREMENTS FINDINGS: a number of major but
      related themes emerged regarding influences on the women's decision-making:
      unpredictability of pre-eclampsia; quality of information received; role of
      others in the decision-making process; perceived personal benefit from trial
      participation; and perception of voluntariness of joining. KEY CONCLUSIONS: the
      data presented give valuable insights into the women's views and experiences of
      decision-making. Research into many of the other elements of care given during
      pregnancy and childbirth is still needed, and with this need comes the ethical
      responsibility of researchers to ensure trials are performed in the most
      scientifically robust ways, which are also acceptable to women. To examine the
      experiences of those involved in trial participation and their views about doing 
      so is a crucial way of advancing this. The QUOTE Study increases understanding of
      the experiences of women participating in a randomised controlled trial.
      IMPLICATIONS FOR PRACTICE: the general implication for practice is that
      procedures are needed that can improve the design and conduct of randomised
      trials and therefore ultimately enhance the experience for future women.
      Recommendations include informed consent should be tailored, recognising
      individual differences in the desire for information. For instance the time
      individuals need to make consent decisions varies, as do their desires to consult
      with family before agreeing.
CI  - Crown Copyright (c) 2011. Published by Elsevier Ltd. All rights reserved.
FAU - Smyth, Rebecca M D
AU  - Smyth RM
AD  - School of Nursing, Midwifery and Social Work, Jean McFarlane Building, University
      of Manchester, Oxford Road, Manchester, M13 9PL,UK. rsmyth@liv.ac.uk
FAU - Jacoby, Ann
AU  - Jacoby A
FAU - Elbourne, Diana
AU  - Elbourne D
LA  - eng
PT  - Journal Article
DEP - 20110922
PL  - Scotland
TA  - Midwifery
JT  - Midwifery
JID - 8510930
RN  - 0 (Anticonvulsants)
MH  - Adult
MH  - Altruism
MH  - Anticonvulsants/adverse effects/therapeutic use
MH  - Chi-Square Distribution
MH  - Choice Behavior
MH  - Female
MH  - Humans
MH  - Multicenter Studies as Topic/psychology
MH  - Nursing Methodology Research
MH  - Patient Acceptance of Health Care/*psychology
MH  - Patient Selection
MH  - Pre-Eclampsia/drug therapy/prevention & control/*psychology
MH  - Pregnancy
MH  - Pregnant Women/*psychology
MH  - Randomized Controlled Trials as Topic/*psychology
MH  - Research Subjects/*psychology
MH  - Statistics, Nonparametric
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2011/09/29 06:00
MHDA- 2012/12/10 06:00
CRDT- 2011/09/28 06:00
PHST- 2011/02/11 00:00 [received]
PHST- 2011/08/07 00:00 [revised]
PHST- 2011/08/10 00:00 [accepted]
PHST- 2011/09/28 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - S0266-6138(11)00120-3 [pii]
AID - 10.1016/j.midw.2011.08.006 [doi]
PST - ppublish
SO  - Midwifery. 2012 Aug;28(4):E478-85. doi: 10.1016/j.midw.2011.08.006. Epub 2011 Sep
      22.


PMID- 21944155
OWN - NLM
STAT- MEDLINE
DCOM- 20120131
LR  - 20140730
IS  - 1533-9866 (Electronic)
IS  - 0029-7828 (Linking)
VI  - 66
IP  - 7
DP  - 2011 Jul
TI  - Cell-free fetal nucleic acid testing: a review of the technology and its
      applications.
PG  - 431-42
LID - 10.1097/OGX.0b013e31822dfbe2 [doi]
AB  - UNLABELLED: Cell-free fetal nucleic acids circulating in the blood of pregnant
      women afford the opportunity for early, noninvasive prenatal genetic testing. The
      predominance of admixed maternal genetic material in circulation demands
      innovative means for identification and analysis of cell-free fetal DNA and RNA. 
      Techniques using polymerase chain reaction, mass spectrometry, and sequencing
      have been developed for the purposes of detecting fetal-specific sequences, such 
      as paternally inherited or de novo mutations, or determining allelic balance or
      chromosome dosage. Clinical applications of these methods include fetal sex
      determination and blood group typing, which are currently available commercially 
      although not offered routinely in the United States. Other uses of cell-free
      fetal DNA and RNA being explored are the detection of single-gene disorders,
      chromosomal abnormalities, and inheritance of parental polymorphisms across the
      whole fetal genome. The concentration of cell-free fetal DNA may also provide
      predictive capabilities for pregnancy-associated complications. The roles that
      cell-free fetal nucleic acid testing assume in the existing framework of prenatal
      screening and invasive diagnostic testing will depend on factors such as costs,
      clinical validity and utility, and perceived benefit-risk ratios for different
      applications. As cell-free fetal DNA and RNA testing continues to be developed
      and translated, significant ethical, legal, and social questions will arise that 
      will need to be addressed by those with a stake in the use of this technology.
      TARGET AUDIENCE: Obstetricians & Gynecologists and Family Physicians Learning
      Objectives: After participating in this activity, physicians should be better
      able to evaluate techniques and tools for analyzing cell-free fetal nucleic
      acids, assess clinical applications of prenatal testing, using cell-free fetal
      nucleic acids and barriers to implementation, and distinguish between relevant
      clinical features of cell-free fetal nucleic acid testing and existing prenatal
      genetic screening and diagnostic procedures.
FAU - Sayres, Lauren C
AU  - Sayres LC
AD  - Stanford Center for Biomedical Ethics, Department of Pediatrics, Division of
      Genetics, Stanford University, Stanford, CA, USA.
FAU - Cho, Mildred K
AU  - Cho MK
LA  - eng
GR  - P50 HG003389/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United States
TA  - Obstet Gynecol Surv
JT  - Obstetrical & gynecological survey
JID - 0401007
RN  - 63231-63-0 (RNA)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Blood Chemical Analysis/methods
MH  - Cell-Free System
MH  - DNA/blood
MH  - Female
MH  - Fetal Diseases/blood/*diagnosis/genetics
MH  - Genetic Testing/*methods
MH  - Humans
MH  - Pregnancy
MH  - Prenatal Diagnosis/*methods
MH  - RNA/blood
MH  - United States
EDAT- 2011/09/29 06:00
MHDA- 2012/02/01 06:00
CRDT- 2011/09/28 06:00
PHST- 2011/09/28 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/02/01 06:00 [medline]
AID - 0006254-201100700-00021 [pii]
AID - 10.1097/OGX.0b013e31822dfbe2 [doi]
PST - ppublish
SO  - Obstet Gynecol Surv. 2011 Jul;66(7):431-42. doi: 10.1097/OGX.0b013e31822dfbe2.


PMID- 21943406
OWN - NLM
STAT- MEDLINE
DCOM- 20120201
LR  - 20220409
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 12
DP  - 2011 Sep 27
TI  - Ethical issues at the interface of clinical care and research practice in
      pediatric oncology: a narrative review of parents' and physicians' experiences.
PG  - 18
LID - 10.1186/1472-6939-12-18 [doi]
AB  - BACKGROUND: Pediatric oncology has a strong research culture. Most pediatric
      oncologists are investigators, involved in clinical care as well as research. As 
      a result, a remarkable proportion of children with cancer enrolls in a trial
      during treatment. This paper discusses the ethical consequences of the
      unprecedented integration of research and care in pediatric oncology from the
      perspective of parents and physicians. METHODOLOGY: An empirical ethical
      approach, combining (1) a narrative review of (primarily) qualitative studies on 
      parents' and physicians' experiences of the pediatric oncology research practice,
      and (2) comparison of these experiences with existing theoretical ethical
      concepts about (pediatric) research. The use of empirical evidence enriches these
      concepts by taking into account the peculiarities that ethical challenges pose in
      practice. RESULTS: Analysis of the 22 studies reviewed revealed that the
      integration of research and care has consequences for the informed consent
      process, the promotion of the child's best interests, and the role of the
      physician (doctor vs. scientist). True consent to research is difficult to
      achieve due to the complexity of research protocols, emotional stress and
      parents' dependency on their child's physician. Parents' role is to promote their
      child's best interests, also when they are asked to consider enrolling their
      child in a trial. Parents are almost never in equipoise on trial participation,
      which leaves them with the agonizing situation of wanting to do what is best for 
      their child, while being fearful of making the wrong decision. Furthermore, a
      therapeutic misconception endangers correct assessment of participation, making
      parents inaccurately attribute therapeutic intent to research procedures.
      Physicians prefer the perspective of a therapist over a researcher. Consequently 
      they may truly believe that in the research setting they promote the child's best
      interests, which maintains the existence of a therapeutic misconception between
      them and parents. CONCLUSION: Due to the integration of research and care, their 
      different ethical perspectives become intertwined in the daily practice of
      pediatric oncology. Increasing awareness of what this means for the communication
      between parents and physicians is essential. Future research should focus on
      efforts that overcome the problems that the synchronicity of research and care
      evokes.
FAU - de Vries, Martine C
AU  - de Vries MC
AD  - Department of Pediatrics, Leiden University Medical Center, J6-S, PO Box 9600,
      2300 RC Leiden, The Netherlands. m.c.de_vries@lumc.nl
FAU - Houtlosser, Mirjam
AU  - Houtlosser M
FAU - Wit, Jan M
AU  - Wit JM
FAU - Engberts, Dirk P
AU  - Engberts DP
FAU - Bresters, Dorine
AU  - Bresters D
FAU - Kaspers, Gertjan J L
AU  - Kaspers GJ
FAU - van Leeuwen, Evert
AU  - van Leeuwen E
LA  - eng
PT  - Journal Article
DEP - 20110927
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Bioethical Issues
MH  - Child
MH  - Clinical Trials as Topic/*ethics
MH  - Decision Making/*ethics
MH  - Empirical Research
MH  - Ethics, Research
MH  - Humans
MH  - Medical Oncology/*ethics
MH  - Narration
MH  - Parental Consent/ethics
MH  - *Parents/psychology
MH  - Patient Care/*ethics
MH  - Pediatrics/*ethics
MH  - *Physician's Role
MH  - *Physicians
MH  - Professional-Family Relations/ethics
MH  - Qualitative Research
MH  - Research Personnel/*ethics
MH  - Therapeutic Equipoise
MH  - Therapeutic Misconception
PMC - PMC3229434
EDAT- 2011/09/29 06:00
MHDA- 2012/02/02 06:00
CRDT- 2011/09/28 06:00
PHST- 2011/02/08 00:00 [received]
PHST- 2011/09/27 00:00 [accepted]
PHST- 2011/09/28 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/02/02 06:00 [medline]
AID - 1472-6939-12-18 [pii]
AID - 10.1186/1472-6939-12-18 [doi]
PST - epublish
SO  - BMC Med Ethics. 2011 Sep 27;12:18. doi: 10.1186/1472-6939-12-18.


PMID- 21943392
OWN - NLM
STAT- MEDLINE
DCOM- 20111214
LR  - 20220321
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 12
DP  - 2011 Sep 26
TI  - Risk communication and informed consent in the medical tourism industry: a
      thematic content analysis of Canadian broker websites.
PG  - 17
LID - 10.1186/1472-6939-12-17 [doi]
AB  - BACKGROUND: Medical tourism, thought of as patients seeking non-emergency medical
      care outside of their home countries, is a growing industry worldwide. Canadians 
      are amongst those engaging in medical tourism, and many are helped in the process
      of accessing care abroad by medical tourism brokers - agents who specialize in
      making international medical care arrangements for patients. As a key source of
      information for these patients, brokers are likely to play an important role in
      communicating the risks and benefits of undergoing surgery or other procedures
      abroad to their clientele. This raises important ethical concerns regarding
      processes such as informed consent and the liability of brokers in the event that
      complications arise from procedures. The purpose of this article is to examine
      the language, information, and online marketing of Canadian medical tourism
      brokers' websites in light of such ethical concerns. METHODS: An exhaustive
      online search using multiple search engines and keywords was performed to compile
      a comprehensive directory of English-language Canadian medical tourism brokerage 
      websites. These websites were examined using thematic content analysis, which
      included identifying informational themes, generating frequency counts of these
      themes, and comparing trends in these counts to the established literature.
      RESULTS: Seventeen websites were identified for inclusion in this study. It was
      found that Canadian medical tourism broker websites varied widely in scope,
      content, professionalism and depth of information. Three themes emerged from the 
      thematic content analysis: training and accreditation, risk communication, and
      business dimensions. Third party accreditation bodies of debatable regulatory
      value were regularly mentioned on the reviewed websites, and discussion of
      surgical risk was absent on 47% of the websites reviewed, with limited discussion
      of risk on the remaining ones. Terminology describing brokers' roles was somewhat
      inconsistent across the websites. Finally, brokers' roles in follow up care,
      their prices, and the speed of surgery were the most commonly included business
      dimensions on the reviewed websites. CONCLUSION: Canadian medical tourism brokers
      currently lack a common standard of care and accreditation, and are widely
      lacking in providing adequate risk communication for potential medical tourists. 
      This has implications for the informed consent and consequent safety of Canadian 
      medical tourists.
FAU - Penney, Kali
AU  - Penney K
AD  - Faculty of Medicine, University of Calgary, 2500 University Drive, NW, Calgary,
      Alberta, Canada.
FAU - Snyder, Jeremy
AU  - Snyder J
FAU - Crooks, Valorie A
AU  - Crooks VA
FAU - Johnston, Rory
AU  - Johnston R
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110926
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Canada
MH  - Choice Behavior
MH  - Confounding Factors, Epidemiologic
MH  - *Decision Making
MH  - Health Care Sector/*ethics
MH  - Humans
MH  - Information Dissemination/*ethics
MH  - Informed Consent/*ethics
MH  - Internet
MH  - Language
MH  - Marketing of Health Services/*ethics/standards
MH  - Medical Tourism/*ethics
MH  - Risk
MH  - Terminology as Topic
PMC - PMC3189886
EDAT- 2011/09/29 06:00
MHDA- 2011/12/15 06:00
CRDT- 2011/09/28 06:00
PHST- 2011/03/22 00:00 [received]
PHST- 2011/09/26 00:00 [accepted]
PHST- 2011/09/28 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2011/12/15 06:00 [medline]
AID - 1472-6939-12-17 [pii]
AID - 10.1186/1472-6939-12-17 [doi]
PST - epublish
SO  - BMC Med Ethics. 2011 Sep 26;12:17. doi: 10.1186/1472-6939-12-17.


PMID- 21943353
OWN - NLM
STAT- MEDLINE
DCOM- 20120208
LR  - 20211020
IS  - 1472-6920 (Electronic)
IS  - 1472-6920 (Linking)
VI  - 11
DP  - 2011 Sep 26
TI  - A survey of current and past Pediatric Infectious Diseases fellows regarding
      training.
PG  - 72
LID - 10.1186/1472-6920-11-72 [doi]
AB  - BACKGROUND: The objectives of this study were to characterize the satisfaction of
      Pediatric Infectious Diseases fellows with their training and to understand how
      opinions about training have changed over time. METHODS: Anonymous survey studies
      were conducted with questions designed to include areas related to the 6 ACGME
      core competencies. Surveys for current fellows were distributed by fellowship
      directors, while surveys for graduates were mailed to all individuals with
      Pediatric Infectious Diseases certification. RESULTS: Response rates for current 
      fellows and graduates were 50% and 52%, respectively. Most fellows (98%) and
      graduates (92%) perceived their overall training favorably. Training in most
      clinical care areas was rated favorably, however both groups perceived relative
      deficiencies in several areas. Current fellows rated their training in other
      competency areas (e.g., systems-based practice, research, and ethics) more
      favorably when compared to past graduates. Recent graduates perceived their
      training more favorably in many of these areas compared to past graduates.
      CONCLUSIONS: Pediatric Infectious Diseases fellowship training is well regarded
      by the majority of current and past trainees. Views of current fellows reflect
      improved satisfaction with training in a variety of competency areas. Persistent 
      deficiencies in clinical training likely reflect active barriers to education.
      Additional study is warranted to validate perceived deficiencies and to establish
      consensus on the importance of these areas to infectious diseases training.
FAU - Douvoyiannis, Miltiadis
AU  - Douvoyiannis M
AD  - Department of Pediatrics, Division of Infectious Diseases, Children's Hospital at
      Montefiore, 3415 Bainbridge Ave, Bronx, NY 10467, USA.
FAU - Litman, Nathan
AU  - Litman N
FAU - Belamarich, Peter F
AU  - Belamarich PF
FAU - Goldman, David L
AU  - Goldman DL
LA  - eng
PT  - Journal Article
DEP - 20110926
PL  - England
TA  - BMC Med Educ
JT  - BMC medical education
JID - 101088679
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Consumer Behavior
MH  - Data Collection
MH  - Education, Medical, Graduate/*standards
MH  - Fellowships and Scholarships
MH  - Humans
MH  - Infectious Disease Medicine/*education
MH  - Pediatrics/*education
MH  - United States
PMC - PMC3188472
EDAT- 2011/09/29 06:00
MHDA- 2012/02/09 06:00
CRDT- 2011/09/28 06:00
PHST- 2011/01/14 00:00 [received]
PHST- 2011/09/26 00:00 [accepted]
PHST- 2011/09/28 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/02/09 06:00 [medline]
AID - 1472-6920-11-72 [pii]
AID - 10.1186/1472-6920-11-72 [doi]
PST - epublish
SO  - BMC Med Educ. 2011 Sep 26;11:72. doi: 10.1186/1472-6920-11-72.


PMID- 21943270
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20181201
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 11
IP  - 10
DP  - 2011 Oct
TI  - Is multiple authorship in conceptual bioethics ethically sustainable?
PG  - 30-2
LID - 10.1080/15265161.2011.603809 [doi]
FAU - Jones, D Gareth
AU  - Jones DG
AD  - University of Otago, Dunedin, New Zealand. gareth.jones@otago.ac.nz
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2011 Oct;11(10):17-21. PMID: 21943265
MH  - *Authorship
MH  - *Bioethics
MH  - Humans
EDAT- 2011/09/29 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/09/28 06:00
PHST- 2011/09/28 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1080/15265161.2011.603809 [doi]
PST - ppublish
SO  - Am J Bioeth. 2011 Oct;11(10):30-2. doi: 10.1080/15265161.2011.603809.


PMID- 21943261
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20181201
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 11
IP  - 10
DP  - 2011 Oct
TI  - The ethically dubious practice of thwarting the redemption of the condemned.
PG  - 9-10
LID - 10.1080/15265161.2011.603800 [doi]
FAU - Johnson, L Syd M
AU  - Johnson LS
AD  - Dalhousie University, Novel Tech Ethics, Halifax, Nova Scotia, Canada.
      syd.johnson@dal.ca
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2011 Oct;11(10):1-5. PMID: 21943258
MH  - *Capital Punishment
MH  - Humans
MH  - Organ Transplantation/*ethics
MH  - *Prisoners
MH  - Tissue Donors/*supply & distribution
MH  - Tissue and Organ Harvesting/*ethics
MH  - Tissue and Organ Procurement/*standards
EDAT- 2011/09/29 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/09/28 06:00
PHST- 2011/09/28 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1080/15265161.2011.603800 [doi]
PST - ppublish
SO  - Am J Bioeth. 2011 Oct;11(10):9-10. doi: 10.1080/15265161.2011.603800.


PMID- 21943258
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20110928
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 11
IP  - 10
DP  - 2011 Oct
TI  - The use of prisoners as sources of organs--an ethically dubious practice.
PG  - 1-5
LID - 10.1080/15265161.2011.607397 [doi]
AB  - The movement to try to close the ever-widening gap between demand and supply of
      organs has recently arrived at the prison gate. While there is enthusiasm for
      using executed prisoners as sources of organs, there are both practical barriers 
      and moral concerns that make it unlikely that proposals to use prisoners will or 
      should gain traction. Prisoners are generally not healthy enough to be a safe
      source of organs, execution makes the procurement of viable organs difficult, and
      organ donation post-execution ties the medical profession too closely to the act 
      of execution.
FAU - Caplan, Arthur
AU  - Caplan A
AD  - Department of Medical Ethics, University of Pennsylvania, Philadelphia,
      19104-3308, USA. caplan@mail.med.upenn.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CIN - Am J Bioeth. 2011 Oct;11(10):6-7. PMID: 21943259
CIN - Am J Bioeth. 2011 Oct;11(10):7-9. PMID: 21943260
CIN - Am J Bioeth. 2011 Oct;11(10):9-10. PMID: 21943261
CIN - Am J Bioeth. 2011 Oct;11(10):11-3. PMID: 21943262
CIN - Am J Bioeth. 2011 Oct;11(10):13-4. PMID: 21943263
CIN - Am J Bioeth. 2011 Oct;11(10):15-6. PMID: 21943264
MH  - Cadaver
MH  - *Capital Punishment
MH  - Ethics, Medical
MH  - Humans
MH  - Living Donors/supply & distribution
MH  - Organ Transplantation/*ethics/standards
MH  - *Prisoners
MH  - Tissue Donors/*supply & distribution
MH  - Tissue and Organ Harvesting/*ethics
MH  - Tissue and Organ Procurement/ethics/*standards
MH  - United States
EDAT- 2011/09/29 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/09/28 06:00
PHST- 2011/09/28 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1080/15265161.2011.607397 [doi]
PST - ppublish
SO  - Am J Bioeth. 2011 Oct;11(10):1-5. doi: 10.1080/15265161.2011.607397.


PMID- 21943172
OWN - NLM
STAT- MEDLINE
DCOM- 20120406
LR  - 20211020
IS  - 1545-2085 (Electronic)
IS  - 0066-4308 (Linking)
VI  - 63
DP  - 2012
TI  - Decoding patterns of human brain activity.
PG  - 483-509
LID - 10.1146/annurev-psych-120710-100412 [doi]
AB  - Considerable information about mental states can be decoded from noninvasive
      measures of human brain activity. Analyses of brain activity patterns can reveal 
      what a person is seeing, perceiving, attending to, or remembering. Moreover,
      multidimensional models can be used to investigate how the brain encodes complex 
      visual scenes or abstract semantic information. Such feats of "brain reading" or 
      "mind reading," though impressive, raise important conceptual, methodological,
      and ethical issues. What does successful decoding reveal about the cognitive
      functions performed by a brain region? How should brain signals be spatially
      selected and mathematically combined to ensure that decoding reflects inherent
      computations of the brain rather than those performed by the decoder? We
      highlight recent advances and describe how multivoxel pattern analysis can
      provide a window into mind-brain relationships with unprecedented specificity,
      when carefully applied. However, as brain-reading technology advances, issues of 
      neuroethics and mental privacy will be important to consider.
FAU - Tong, Frank
AU  - Tong F
AD  - Psychology Department and Vanderbilt Vision Research Center, Vanderbilt
      University, Nashville, Tennessee 37240, USA. frank.tong@vanderbilt.edu
FAU - Pratte, Michael S
AU  - Pratte MS
LA  - eng
GR  - R01 EY017082/EY/NEI NIH HHS/United States
GR  - R01EY017082/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20110919
PL  - United States
TA  - Annu Rev Psychol
JT  - Annual review of psychology
JID - 0372374
SB  - IM
MH  - Brain/*physiology
MH  - Brain Mapping/*methods
MH  - Functional Neuroimaging/*methods
MH  - Humans
MH  - Image Processing, Computer-Assisted/*methods
MH  - Magnetic Resonance Imaging/methods
MH  - Memory/physiology
MH  - Visual Perception/physiology
PMC - PMC7869795
MID - NIHMS1662796
EDAT- 2011/09/29 06:00
MHDA- 2012/04/07 06:00
CRDT- 2011/09/28 06:00
PHST- 2011/09/28 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/04/07 06:00 [medline]
AID - 10.1146/annurev-psych-120710-100412 [doi]
PST - ppublish
SO  - Annu Rev Psychol. 2012;63:483-509. doi: 10.1146/annurev-psych-120710-100412. Epub
      2011 Sep 19.


PMID- 21943170
OWN - NLM
STAT- MEDLINE
DCOM- 20120406
LR  - 20130212
IS  - 1545-2085 (Electronic)
IS  - 0066-4308 (Linking)
VI  - 63
DP  - 2012
TI  - Human intracranial recordings and cognitive neuroscience.
PG  - 511-37
LID - 10.1146/annurev-psych-120709-145401 [doi]
AB  - The ultimate goal of neuroscience research is to understand the operating
      mechanism of the human brain and to exploit this understanding to devise methods 
      for repair when it malfunctions. A key feature of this operating mechanism is
      electrical activity of single brain cells and cell assemblies. For obvious
      ethical reasons, scientists rely mostly on animal research in the study of such
      signals. Research in humans is often limited to electrical signals that can be
      recorded at the scalp or to surrogates of electrical activity, namely magnetic
      source imaging and measures of regional blood flow and metabolism. Invasive brain
      recordings performed in patients during various clinical procedures provide a
      unique opportunity to record high-resolution signals in vivo from the human
      brain-data that are otherwise unavailable. Of special value are the rare
      opportunities to record in awake humans the activity of single brain cells and
      small cellular assemblies. These recordings provide a unique view on aspects of
      human cognition that are impossible to study in animals, including language,
      imagery, episodic memory, volition, and even consciousness. In the current review
      we discuss the unique contribution of invasive recordings from patients to the
      field of cognitive neuroscience.
FAU - Mukamel, Roy
AU  - Mukamel R
AD  - Department of Neurosurgery, David Geffen School of Medicine and Semel Institute
      for Neuroscience and Human Behavior, University of California, Los Angeles,
      90095, USA. rmukamel@post.tau.ac.il
FAU - Fried, Itzhak
AU  - Fried I
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110919
PL  - United States
TA  - Annu Rev Psychol
JT  - Annual review of psychology
JID - 0372374
SB  - IM
MH  - Brain/*physiology
MH  - Cognition/*physiology
MH  - *Deep Brain Stimulation
MH  - *Electroencephalography
MH  - Emotions/physiology
MH  - Humans
MH  - Language
MH  - Memory/physiology
MH  - Perception/physiology
EDAT- 2011/09/29 06:00
MHDA- 2012/04/07 06:00
CRDT- 2011/09/28 06:00
PHST- 2011/09/28 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/04/07 06:00 [medline]
AID - 10.1146/annurev-psych-120709-145401 [doi]
PST - ppublish
SO  - Annu Rev Psychol. 2012;63:511-37. doi: 10.1146/annurev-psych-120709-145401. Epub 
      2011 Sep 19.


PMID- 21943067
OWN - NLM
STAT- MEDLINE
DCOM- 20120202
LR  - 20211020
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 12
DP  - 2011 Sep 26
TI  - DIABRISK-SL prevention of cardio-metabolic disease with life style modification
      in young urban Sri Lankan's--study protocol for a randomized controlled trial.
PG  - 209
LID - 10.1186/1745-6215-12-209 [doi]
AB  - BACKGROUND: Urban South-Asian's are predisposed to early onset of type 2 diabetes
      mellitus (T2DM) and cardiovascular disease (CVD). There is an urgent need for
      country specific primary prevention strategies to address the growing burden of
      cardio-metabolic disease in this population. The aim of this clinical trial is to
      evaluate whether intensive (3-monthly) lifestyle modification advice is superior 
      to a less-intensive (12 monthly; control group) lifestyle modification advice on 
      a primary composite cardio-metabolic end point in 'at risk' urban subjects aged
      between 5-40 years. METHODS/DESIGN: This is an open randomised controlled
      parallel group clinical trial performed at a single centre in Colombo, Sri-Lanka.
      A cluster sampling strategy was used to select a large representative sample of
      subjects aged between 5-40 years at high risk of T2DM and CVD for the
      intervention study. We have screened 23,298 (males 47% females 53%) healthy
      subjects for four risk factors: obesity, elevated waist circumference, family
      history of diabetes and physical inactivity, using a questionnaire and
      anthropometry. Those with two or more risk-factors were recruited to the
      intervention trial. We aim to recruit 4600 subjects for the intervention trial.
      The primary composite cardio-metabolic end point is; new onset T2DM, impaired
      glucose tolerance, impaired fasting glycaemia, new onset hypertension and
      albuminuria, following 5 years of intervention. The effect of the intervention on
      pre-specified secondary endpoints will also be evaluated. The study will be
      conducted according to good clinical and ethical practice, data analysis and
      reporting guidelines. DISCUSSION: DIABRISK-SL is a large population based trial
      to evaluate the prevalence of diabetes, pre-diabetes and cardio-metabolic risk
      factors among young urban Sri-Lankans and the effect of a primary prevention
      strategy on cardio-metabolic disease end points. This work will enable country
      specific and regional cardio-metabolic risk scores to be derived. Further if the 
      proposed intervention is successful the results of this study can be translated
      and implemented as a low-cost primary prevention tool in Sri-Lanka and other
      low/middle income developing countries. TRIAL REGISTRATION: The trial is
      registered with the World Health Organisation and Sri-Lanka clinical trial
      registry number SLCTR/2008/003.
FAU - Wijesuriya, Mahen
AU  - Wijesuriya M
AD  - Diabetes Association of Sri Lanka, National Diabetes Centre, Colombo, Sri Lanka.
FAU - Gulliford, Martin
AU  - Gulliford M
FAU - Vasantharajah, Laksha
AU  - Vasantharajah L
FAU - Viberti, Giancarlo
AU  - Viberti G
FAU - Gnudi, Luigi
AU  - Gnudi L
FAU - Karalliedde, Janaka
AU  - Karalliedde J
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110926
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cardiovascular Diseases/*prevention & control
MH  - Child
MH  - Child, Preschool
MH  - *Clinical Protocols
MH  - Diabetes Mellitus, Type 2/*prevention & control
MH  - Female
MH  - Humans
MH  - *Life Style
MH  - Male
MH  - Research Design
MH  - Sri Lanka
PMC - PMC3197497
EDAT- 2011/09/29 06:00
MHDA- 2012/02/03 06:00
CRDT- 2011/09/28 06:00
PHST- 2011/05/12 00:00 [received]
PHST- 2011/09/26 00:00 [accepted]
PHST- 2011/09/28 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/02/03 06:00 [medline]
AID - 1745-6215-12-209 [pii]
AID - 10.1186/1745-6215-12-209 [doi]
PST - epublish
SO  - Trials. 2011 Sep 26;12:209. doi: 10.1186/1745-6215-12-209.


PMID- 21942589
OWN - NLM
STAT- MEDLINE
DCOM- 20120202
LR  - 20121115
IS  - 1476-4954 (Electronic)
IS  - 1476-4954 (Linking)
VI  - 24 Suppl 1
DP  - 2011 Oct
TI  - Pharmacological research in neonatology.
PG  - 44-6
LID - 10.3109/14767058.2011.607580 [doi]
AB  - In neonatology unit 40 to 80% of the drugs are used as off-label or unlicensed,
      particularly in Neonatal Intensive Care Unit (NICU), where it has been described 
      that in a single patient up to 60 parenteral drugs can be administered. The
      course of a drug inside the organism can be defined in 4 different phases:
      absorption, distribution, metabolism, elimination; for each of these phases the
      newborn infant has different characteristics than child and adult. In the last
      years much more attention has been put in pharmacological research specific for
      the neonatal age and a good trial design should take into account the following
      points: (1) to define the pediatric disease in terms of natural history,
      prevalence, severity, treatment and impact of the new drug; (2) to avoid the "try
      and error" method based on the adult dose corrected for weight or age; (3) to use
      adapted methodologies (pharmacokinetics); (4) to avoid small clinical trials
      (limited number of patients), the use of Randomized Controlled Trials rather than
      observational studies; (5) to consider ethics providing clear information and
      reducing pain and stress to the baby and its family.
FAU - Dotta, Andrea
AU  - Dotta A
AD  - Neonatal Intensive and Subintensive Care Unit and Department of Medical and
      Surgical Neonatology, Bambino Gesu Children's Hospital, Rome, Italy.
      ndrea.dotta@opbg.net
FAU - Braguglia, Annabella
AU  - Braguglia A
FAU - Salvatori, Guglielmo
AU  - Salvatori G
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Matern Fetal Neonatal Med
JT  - The journal of maternal-fetal & neonatal medicine : the official journal of the
      European Association of Perinatal Medicine, the Federation of Asia and Oceania
      Perinatal Societies, the International Society of Perinatal Obstetricians
JID - 101136916
SB  - IM
MH  - *Drug Discovery/methods
MH  - Humans
MH  - Infant, Newborn
MH  - Intensive Care Units, Neonatal/statistics & numerical data
MH  - Models, Biological
MH  - Neonatology/*methods/statistics & numerical data
MH  - Pharmacokinetics
MH  - Pharmacology, Clinical/methods/statistics & numerical data/trends
MH  - Prospective Studies
MH  - Research/statistics & numerical data/trends
MH  - *Research Design
EDAT- 2011/09/29 06:00
MHDA- 2012/02/03 06:00
CRDT- 2011/09/28 06:00
PHST- 2011/09/28 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/02/03 06:00 [medline]
AID - 10.3109/14767058.2011.607580 [doi]
PST - ppublish
SO  - J Matern Fetal Neonatal Med. 2011 Oct;24 Suppl 1:44-6. doi:
      10.3109/14767058.2011.607580.


PMID- 21942316
OWN - NLM
STAT- MEDLINE
DCOM- 20120127
LR  - 20220317
IS  - 1939-2192 (Electronic)
IS  - 1076-898X (Linking)
VI  - 17
IP  - 3
DP  - 2011 Sep
TI  - Effective communication of risks to young adults: using message framing and
      visual aids to increase condom use and STD screening.
PG  - 270-87
LID - 10.1037/a0023677 [doi]
AB  - Sexually Transmitted Diseases (STDs)-including HIV/AIDS-are among the most common
      infectious diseases in young adults. How can we effectively promote prevention
      and detection of STDs in this high risk population? In a two-phase longitudinal
      experiment we examined the effects of a brief risk awareness intervention (i.e., 
      a sexual health information brochure) in a large sample of sexually active young 
      adults (n = 744). We assessed the influence of gain- and loss-framed messages,
      and visual aids, on affective reactions, risk perceptions, attitudes, behavioral 
      intentions, and reported behaviors relating to the prevention and detection of
      STDs. Results indicate that gain-framed messages induced greater adherence for
      prevention behaviors (e.g., condom use), whereas loss-framed messages were more
      effective in promoting illness-detecting behaviors (e.g., making an appointment
      with a doctor to discuss about STD screening). The influence of the framed
      messages on prevention and detection of STDs was mediated by changes in
      participants' attitudes toward the health behaviors along with changes in their
      behavioral intentions. Moreover, when visual aids were added to the health
      information, both the gain- and loss-framed messages became equally and highly
      effective in promoting health behaviors. These results converge with other data
      indicating that well-constructed visual aids are often among the most highly
      effective, transparent, fast, memorable, and ethically desirable means of risk
      communication. Theoretical, economic, and public policy implications of these
      results are discussed.
CI  - (c) 2011 APA, all rights reserved.
FAU - Garcia-Retamero, Rocio
AU  - Garcia-Retamero R
AD  - Department of Psychology, University ofGranada, Granada, Spain. rretamer@ugr.es
FAU - Cokely, Edward T
AU  - Cokely ET
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Exp Psychol Appl
JT  - Journal of experimental psychology. Applied
JID - 9507618
SB  - IM
MH  - Adolescent
MH  - *Audiovisual Aids
MH  - Condoms/*statistics & numerical data
MH  - Contraception Behavior/*psychology
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Male
MH  - Pamphlets
MH  - Risk
MH  - *Safe Sex
MH  - Sex Education/*methods
MH  - Sexually Transmitted Diseases/*diagnosis/prevention & control
EDAT- 2011/09/29 06:00
MHDA- 2012/01/28 06:00
CRDT- 2011/09/28 06:00
PHST- 2011/09/28 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2012/01/28 06:00 [medline]
AID - 2011-21481-007 [pii]
AID - 10.1037/a0023677 [doi]
PST - ppublish
SO  - J Exp Psychol Appl. 2011 Sep;17(3):270-87. doi: 10.1037/a0023677.


PMID- 21941926
OWN - NLM
STAT- MEDLINE
DCOM- 20111102
LR  - 20110926
IS  - 1092-0811 (Print)
IS  - 1092-0811 (Linking)
VI  - 20
IP  - 4
DP  - 2011 Jul-Aug
TI  - What about ethics?
PG  - 162
FAU - Roberts, Dottie
AU  - Roberts D
LA  - eng
PT  - Editorial
PL  - United States
TA  - Medsurg Nurs
JT  - Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses
JID - 9300545
MH  - Decision Making/*ethics
MH  - *Ethics, Nursing
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Nurse-Patient Relations/*ethics
MH  - United States
EDAT- 2011/09/29 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/09/28 06:00
PHST- 2011/09/28 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
PST - ppublish
SO  - Medsurg Nurs. 2011 Jul-Aug;20(4):162.


PMID- 21941879
OWN - NLM
STAT- MEDLINE
DCOM- 20111013
LR  - 20190918
IS  - 0002-726X (Print)
IS  - 0002-726X (Linking)
VI  - 156
IP  - 3
DP  - 2011 Summer
TI  - Deaf parents and pediatric cochlear implantation: an exploration of the
      decision-making process.
PG  - 290-304
AB  - The study examined factors in deaf parents' decision between cochlear
      implantation (CI) and traditional hearing aids for their child. The subjects were
      6 Flemish children ages 5-9 years with severe/profound congenital hearing loss,
      with at least 1 deaf parent. The researchers, who conducted thematic content
      analysis of qualitative data collected through parent interviews, found that with
      the exception of a family with 1 hearing parent, parents gave priority to Deaf
      identity, sign language, and ethical issues in deciding between CI and hearing
      aids. Medical risks were also mentioned. The researchers conclude that the
      decision-making processes of the parents involved factors that have also been
      found among hearing parents, as well as aspects that have not been reported to
      play a role in hearing parents' decision making. A further conclusion is that
      deaf parents' perspective merits attention in professional practice and empirical
      research.
FAU - Hardonk, Stefan
AU  - Hardonk S
AD  - Department of Medical Sociology, Vrije Universiteit Brussel, Brussels, Belgium. ,
      stefan.hardonk@vub.ac.be
FAU - Daniels, Sarah
AU  - Daniels S
FAU - Desnerck, Greetje
AU  - Desnerck G
FAU - Loots, Gerrit
AU  - Loots G
FAU - Van Hove, Geert
AU  - Van Hove G
FAU - Van Kerschaver, Erwin
AU  - Van Kerschaver E
FAU - Sigurjonsdottir, Hanna Bjorg
AU  - Sigurjonsdottir HB
FAU - Vanroelen, Christophe
AU  - Vanroelen C
FAU - Louckx, Fred
AU  - Louckx F
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am Ann Deaf
JT  - American annals of the deaf
JID - 0414670
SB  - IM
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Cochlear Implantation/ethics/*psychology
MH  - Deafness/*psychology/*surgery/therapy
MH  - *Decision Making
MH  - Female
MH  - Hearing Aids/ethics/psychology
MH  - Humans
MH  - Male
MH  - Parents/*psychology
MH  - Patient Acceptance of Health Care/*psychology
MH  - Sign Language
EDAT- 2011/09/29 06:00
MHDA- 2011/10/14 06:00
CRDT- 2011/09/28 06:00
PHST- 2011/09/28 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2011/10/14 06:00 [medline]
AID - 10.1353/aad.2011.0027 [doi]
PST - ppublish
SO  - Am Ann Deaf. 2011 Summer;156(3):290-304. doi: 10.1353/aad.2011.0027.


PMID- 21941805
OWN - NLM
STAT- MEDLINE
DCOM- 20111013
LR  - 20161125
IS  - 0029-6570 (Print)
IS  - 0029-6570 (Linking)
VI  - 25
IP  - 52
DP  - 2011 Aug 31-Sep 6
TI  - Understanding the NMC code of conduct: a student perspective.
PG  - 35-9
AB  - The Code, published by the Nursing and Midwifery Council (NMC) (2008), provides
      standards of performance and ethics for nurses and midwives, and is a means of
      safeguarding the health and wellbeing of the public. Guidance from the NMC may
      appear relatively straightforward, however it can be difficult to implement in
      practice. This article identifies specific challenges that nurses may be
      presented with when adhering to The Code, as well as more general issues in
      interpreting the standards.
FAU - Sutcliffe, Hannah
AU  - Sutcliffe H
AD  - King's College London.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Stand
JT  - Nursing standard (Royal College of Nursing (Great Britain) : 1987)
JID - 9012906
MH  - *Ethics, Nursing
MH  - Nurse-Patient Relations
MH  - Professional Competence
MH  - Students, Nursing/*psychology
MH  - United Kingdom
EDAT- 2011/09/29 06:00
MHDA- 2011/10/14 06:00
CRDT- 2011/09/28 06:00
PHST- 2011/09/28 06:00 [entrez]
PHST- 2011/09/29 06:00 [pubmed]
PHST- 2011/10/14 06:00 [medline]
AID - 10.7748/ns2011.08.25.52.35.c8676 [doi]
PST - ppublish
SO  - Nurs Stand. 2011 Aug 31-Sep 6;25(52):35-9. doi: 10.7748/ns2011.08.25.52.35.c8676.


PMID- 21941458
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1178-7090 (Electronic)
IS  - 1178-7090 (Linking)
VI  - 4
DP  - 2011
TI  - Measuring children's distress during burns dressing changes: literature search
      for measures appropriate for indigenous children in South Africa.
PG  - 263-77
LID - 10.2147/JPR.S21821 [doi]
AB  - BACKGROUND: Virtual reality is consistently reported as effective in reducing
      pain and anxiety in children during burns dressing changes in recent Western
      studies. Pain scales are a commonly reported outcome measure. Virtual reality is 
      persuasive for all children in distress during medical procedures, because it is 
      a nonaddictive, novel, and inexpensive form of distraction which can be applied
      repeatedly with good effect. We intend to use virtual reality in South Africa for
      the many children hospitalized with severe burns from mechanisms rarely seen in
      the Western world (paraffin/kerosene stoves exploding, electrical fires,
      shack/township fires, boiling liquid spills). Many severely burnt children are
      indigenous South Africans who did not speak English, and whose illiteracy levels,
      cultures, family dynamics, and experiences of pain potentially invalidate the use
      of conventional pain scales as outcome measures. The purpose of this study was to
      identify objective measures with sound psychometric properties and strong
      clinical utility, to assess distress during burns dressing changes in
      hospitalized indigenous South African children. Choice of measures was
      constrained by the burns dressing change environment, the ethics of doing no harm
      whilst measuring distress in vulnerable children, and of capturing valid measures
      of distress over the entire burns dressing change procedure. METHODS: We
      conducted two targeted systematic reviews of the literature. All major library
      databases were searched, and measures with strong psychometric properties and
      sound clinical utility were sought. RESULTS: Seven potentially useful measures
      were identified, ie, child's and caregivers' heart rate, which was measured
      continuously throughout the procedure, observed physical manifestations of
      distress using different scales (FLACCs [Face, Legs, Activity, Cry, Consolability
      Scale] and/ or Pain Behavior Checklist), time taken, and number of staff required
      to complete the procedure, and staff perspectives on the ease of use of the
      procedure. CONCLUSION: These psychometrically sound, clinically useful measures
      are alternatives to conventional pain scales, and should support valid research
      into the effectiveness of virtual reality for illiterate children with
      non-Western cultures and languages.
FAU - Louw, Quinette
AU  - Louw Q
AD  - Department of Physiotherapy, Stellenbosch University, Cape Town, South Africa.
FAU - Grimmer-Somers, Karen
AU  - Grimmer-Somers K
FAU - Schrikk, Angie
AU  - Schrikk A
LA  - eng
PT  - Journal Article
DEP - 20110906
PL  - New Zealand
TA  - J Pain Res
JT  - Journal of pain research
JID - 101540514
PMC - PMC3176143
OTO - NOTNLM
OT  - anxiety
OT  - burns
OT  - children
OT  - distress
OT  - measurement
OT  - pain
OT  - validity
EDAT- 2011/09/24 06:00
MHDA- 2011/09/24 06:01
CRDT- 2011/09/24 06:00
PHST- 2011/09/24 06:00 [entrez]
PHST- 2011/09/24 06:00 [pubmed]
PHST- 2011/09/24 06:01 [medline]
AID - 10.2147/JPR.S21821 [doi]
AID - jpr-4-263 [pii]
PST - ppublish
SO  - J Pain Res. 2011;4:263-77. doi: 10.2147/JPR.S21821. Epub 2011 Sep 6.


PMID- 21941154
OWN - NLM
STAT- MEDLINE
DCOM- 20111118
LR  - 20161125
IS  - 1541-8243 (Electronic)
IS  - 0038-4348 (Linking)
VI  - 104
IP  - 10
DP  - 2011 Oct
TI  - "Murder or mercy?" An innovative module helping UK medical students to articulate
      their own ethical viewpoints regarding end-of-life decisions.
PG  - 676-81
LID - 10.1097/SMJ.0b013e31822ceff8 [doi]
AB  - This module was designed to equip UK medical students to respond ethically and
      sensitively to requests encountered as qualified doctors regarding euthanasia and
      assisted dying. The aim was to expose students to relevant opinions and
      experiences and provide opportunities to explore and justify their own views and 
      rehearse ethical decision making in a safe learning environment.The module is
      delivered by a multidisciplinary team, providing students with the working
      knowledge to actively discuss cases, articulate their own views and practice
      ethical reasoning. Visits to intensive care units, palliative care wards and
      hospices are integrated with theory. Student assessment comprises a dissertation,
      debate and reflection. Module impact was evaluated by analysis of student
      coursework and a questionnaire.Students greatly appreciated the clinical context 
      provided by the visits and opportunities to apply ethical reasoning to cases and 
      debate issues with peers. They reported increased discernment of the ethical and 
      legal position and practical considerations and greater awareness of the range of
      professional and lay viewpoints held. Many participants were less strongly in
      favor of euthanasia and assisted dying on module completion than at the outset,
      but all of them believed they were better equipped to justify their own viewpoint
      and respond to patient requests. The multi-disciplinary nature of this course
      helps to prepare students to deal effectively and sensitively with ethical
      dilemmas they will encounter in their medical career. Use of an integrated,
      learner-centred approach equips students to actively engage with their peers in
      discussion of such issues and to formulate and defend their own position.
FAU - Bell, David
AU  - Bell D
AD  - Centre for Medical Education, The Queen's University of Belfast, UK.
      d.bell@qub.ac.uk
FAU - Crawford, Vivienne
AU  - Crawford V
LA  - eng
PT  - Journal Article
PL  - United States
TA  - South Med J
JT  - Southern medical journal
JID - 0404522
SB  - IM
CIN - South Med J. 2011 Oct;104(10):682-3. PMID: 21941155
MH  - Adult
MH  - Decision Making/*ethics
MH  - Education, Medical, Undergraduate/*methods
MH  - Educational Measurement
MH  - Euthanasia/*ethics
MH  - Female
MH  - *Homicide/ethics
MH  - Humans
MH  - Interdisciplinary Communication
MH  - Male
MH  - Models, Educational
MH  - *Students, Medical
MH  - Surveys and Questionnaires
MH  - *Terminally Ill
MH  - United Kingdom
EDAT- 2011/09/24 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/09/24 06:00
PHST- 2011/09/24 06:00 [entrez]
PHST- 2011/09/24 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1097/SMJ.0b013e31822ceff8 [doi]
AID - 00007611-201110000-00002 [pii]
PST - ppublish
SO  - South Med J. 2011 Oct;104(10):676-81. doi: 10.1097/SMJ.0b013e31822ceff8.


PMID- 21941058
OWN - NLM
STAT- MEDLINE
DCOM- 20120131
LR  - 20151221
IS  - 0972-2823 (Electronic)
IS  - 0022-3859 (Linking)
VI  - 57
IP  - 3
DP  - 2011 Jul-Sep
TI  - A study of drug-drug interactions in cancer patients of a south Indian tertiary
      care teaching hospital.
PG  - 206-10
LID - 10.4103/0022-3859.85207 [doi]
AB  - BACKGROUND: Drug interactions in oncology are of particular importance owing to
      the narrow therapeutic index and the inherent toxicity of anticancer agents.
      Interactions with other medications can cause small change in pharmacokinetics or
      pharmacodynamics of chemotherapeutic agents that could significantly alter their 
      safety and efficacy. AIM: To identify and document the potential drug-drug
      interactions in prescriptions of patients receiving cancer chemotherapy. Settings
      and Design : A tertiary care teaching hospital based prospective study. MATERIALS
      AND METHODS: Patients admitted in the medical oncology wards with different types
      of malignancies and receiving cancer chemotherapy during the period of June 2009 
      to November 2009 were included in the study. A detailed data collection was done 
      in a specially designed proforma with ethical approval and consent of patients
      and their prescriptions were subjected to drug-drug interaction screening using
      Drug Interaction Fact Software Version-4 and standard references. Incidence of
      drug-drug interactions, their types, correlation between age, cancer type, number
      of drugs prescribed and incidence of drug interactions were analyzed. STATISTICAL
      ANALYSIS: Logistic regression analysis and Odds ratio were performed to identify 
      the incidence of drug-drug interactions and their correlation with the factors
      above mentioned. RESULTS: A total of 75 patients (32 males and 43 females; median
      age 56 years, age range 23-74) were enrolled in the study and their prescriptions
      were screened. 213 interactions were identified of which, 21 were major, 121 were
      moderate and 71 were minor. There were 13 (6.1%) clinically significant
      interactions between anticancer drugs and 14 (6.5%) drug-drug interactions
      between anticancer drugs and other drugs prescribed for co-morbidities. There was
      a positive correlation between number of drugs prescribed and drug interactions
      (P=0.011; OR 0.903). CONCLUSION: Though there was not any life threatening
      interactions, the potential interactions were brought to the oncologist purview
      for ensuring patients safety and to avoid undesirable effects.
FAU - Kannan, G
AU  - Kannan G
AD  - Department of Pharmacy Practice, Sri Ramachandra University, Porur, Chennai,
      Tamil Nadu, India. kannagg2@yahoo.ca
FAU - Anitha, R
AU  - Anitha R
FAU - Rani, Vanitha N
AU  - Rani VN
FAU - Thennarasu, P
AU  - Thennarasu P
FAU - Alosh, J
AU  - Alosh J
FAU - Vasantha, J
AU  - Vasantha J
FAU - Martin, J R
AU  - Martin JR
FAU - Uma, M R C
AU  - Uma MR
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - India
TA  - J Postgrad Med
JT  - Journal of postgraduate medicine
JID - 2985196R
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antineoplastic Agents/*therapeutic use
MH  - Drug Interactions
MH  - Drug-Related Side Effects and Adverse Reactions/*epidemiology
MH  - Female
MH  - Hospitals, Teaching/*statistics & numerical data
MH  - Humans
MH  - Incidence
MH  - India/epidemiology
MH  - Male
MH  - Medication Errors
MH  - Middle Aged
MH  - Neoplasms/*drug therapy/epidemiology
MH  - Prospective Studies
MH  - Young Adult
EDAT- 2011/09/24 06:00
MHDA- 2012/02/01 06:00
CRDT- 2011/09/24 06:00
PHST- 2011/09/24 06:00 [entrez]
PHST- 2011/09/24 06:00 [pubmed]
PHST- 2012/02/01 06:00 [medline]
AID - jpgm_2011_57_3_206_85207 [pii]
AID - 10.4103/0022-3859.85207 [doi]
PST - ppublish
SO  - J Postgrad Med. 2011 Jul-Sep;57(3):206-10. doi: 10.4103/0022-3859.85207.


PMID- 21940928
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20211020
IS  - 1541-0048 (Electronic)
IS  - 0090-0036 (Linking)
VI  - 101
IP  - 11
DP  - 2011 Nov
TI  - Studies with staggered starts: multiple baseline designs and group-randomized
      trials.
PG  - 2164-9
LID - 10.2105/AJPH.2011.300264 [doi]
AB  - OBJECTIVES: Multiple baseline designs (MBDs) have been suggested as alternatives 
      to group-randomized trials (GRT). We reviewed structural features of MBDs and
      considered their potential effectiveness in public health research. We also
      reviewed the effect of staggered starts on statistical power. METHODS: We
      reviewed the MBD literature to identify key structural features, recent
      suggestions that MBDs be adopted in public health research, and the literature on
      power in GRTs with staggered starts. We also computed power for MBDs and GRTs.
      RESULTS: The features that have contributed to the success of small MBDs in some 
      fields are not likely to translate well to public health research. MBDs can be
      more powerful than GRTs under some conditions, but those conditions involve
      assumptions that require careful evaluation in practice. CONCLUSIONS: MBDs will
      often serve better as a complement of rather than as an alternative to GRTs. GRTs
      may employ staggered starts for logistical or ethical reasons, but this will
      always increase their duration and will often increase their cost.
FAU - Rhoda, Dale A
AU  - Rhoda DA
AD  - Centers for Public Health Research and Evaluation, Battelle Memorial Institute,
      Columbus, OH 43201, USA. RhodaD@battelle.org
FAU - Murray, David M
AU  - Murray DM
FAU - Andridge, Rebecca R
AU  - Andridge RR
FAU - Pennell, Michael L
AU  - Pennell ML
FAU - Hade, Erinn M
AU  - Hade EM
LA  - eng
GR  - P50 CA105632/CA/NCI NIH HHS/United States
GR  - P50CA105632/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20110922
PL  - United States
TA  - Am J Public Health
JT  - American journal of public health
JID - 1254074
SB  - IM
EIN - Am J Public Health. 2014 Mar;104(3):e12
MH  - Clinical Trials as Topic/*methods
MH  - Humans
MH  - *Public Health
MH  - Randomized Controlled Trials as Topic
MH  - *Research Design
PMC - PMC3222403
EDAT- 2011/09/24 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/09/24 06:00
PHST- 2011/09/24 06:00 [entrez]
PHST- 2011/09/24 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - AJPH.2011.300264 [pii]
AID - 10.2105/AJPH.2011.300264 [doi]
PST - ppublish
SO  - Am J Public Health. 2011 Nov;101(11):2164-9. doi: 10.2105/AJPH.2011.300264. Epub 
      2011 Sep 22.


PMID- 21940921
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20211020
IS  - 1541-0048 (Electronic)
IS  - 0090-0036 (Linking)
VI  - 101
IP  - 11
DP  - 2011 Nov
TI  - Wake me up when there's a crisis: progress on state pandemic influenza ethics
      preparedness.
PG  - 2080-2
LID - 10.2105/AJPH.2011.300293 [doi]
AB  - We assessed the progress since 2005 of state plans for pandemic influenza and
      found that 7 states had recommended steps to further clarify ethical processes or
      decisions; 6 states had made some progress but almost exclusively in hospital
      preparedness. Having a high-level public health leader, such as a health
      department director, committed to ethics was the key determinant of progress.
      Some state health departments may be destined to gain an appreciation for ethics 
      through ethical mishaps.
FAU - Thomas, James C
AU  - Thomas JC
AD  - MEASURE Evaluation, Chapel Hill, NC 27517, USA. jim.thomas@unc.edu
FAU - Young, Siobhan
AU  - Young S
LA  - eng
GR  - P01 TP000296/TP/OPHPR CDC HHS/United States
GR  - R24 HD050924/HD/NICHD NIH HHS/United States
GR  - P01TP000296/TP/OPHPR CDC HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20110922
PL  - United States
TA  - Am J Public Health
JT  - American journal of public health
JID - 1254074
SB  - IM
CIN - Am J Public Health. 2012 Aug;102(8):e8; author reply e8-9. PMID: 22698030
MH  - Disaster Planning/*organization & administration
MH  - *Ethics, Clinical
MH  - Humans
MH  - Influenza, Human/*epidemiology
MH  - Pandemics
MH  - *Public Health Administration
MH  - *State Government
MH  - United States
MH  - World Health Organization
PMC - PMC3222399
EDAT- 2011/09/24 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/09/24 06:00
PHST- 2011/09/24 06:00 [entrez]
PHST- 2011/09/24 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - AJPH.2011.300293 [pii]
AID - 10.2105/AJPH.2011.300293 [doi]
PST - ppublish
SO  - Am J Public Health. 2011 Nov;101(11):2080-2. doi: 10.2105/AJPH.2011.300293. Epub 
      2011 Sep 22.


PMID- 21940424
OWN - NLM
STAT- MEDLINE
DCOM- 20120117
LR  - 20110923
IS  - 1527-1927 (Electronic)
IS  - 0361-6878 (Linking)
VI  - 36
IP  - 4
DP  - 2011 Aug
TI  - Addressing the shortage of kidneys for transplantation: purchase and allocation
      through chain auctions.
PG  - 717-55
LID - 10.1215/03616878-1334695 [doi]
AB  - Transplantation is generally the treatment of choice for those suffering from
      kidney failure. Not only does transplantation offer improved quality of life and 
      increased longevity relative to dialysis, it also reduces end-stage renal disease
      program expenditures, providing savings to Medicare. Unfortunately, the waiting
      list for kidney transplants is long, growing, and unlikely to be substantially
      reduced by increases in the recovery of cadaveric kidneys. Another approach is to
      obtain more kidneys through payment to living "donors," or vendors. Such direct
      commodification, in which a price is placed on kidneys, has generally been
      opposed by medical ethicists. Much of the ethical debate, however, has been in
      terms of commodification through market exchange. Recognizing that there are
      different ethical concerns associated with the purchase of kidneys and their
      allocation, it is possible to design a variety of institutional arrangements for 
      the commodification of kidneys that pose different sets of ethical concerns. We
      specify three such alternatives in detail sufficient to allow an assessment of
      their likely consequences and we compare these alternatives to current policy in 
      terms of the desirable goals of promoting human dignity, equity, efficiency, and 
      fiscal advantage. This policy analysis leads us to recommend that kidneys be
      purchased at administered prices by a nonprofit organization and allocated to the
      transplant centers that can organize the longest chains of transplants involving 
      willing-but-incompatible donor-patient dyads.
FAU - Rosen, Lara
AU  - Rosen L
AD  - University of Wisconsin, USA.
FAU - Vining, Aidan R
AU  - Vining AR
FAU - Weimer, David L
AU  - Weimer DL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Health Polit Policy Law
JT  - Journal of health politics, policy and law
JID - 7609331
SB  - IM
CIN - J Health Polit Policy Law. 2011 Aug;36(4):757-61. PMID: 21940425
CIN - J Health Polit Policy Law. 2011 Aug;36(4):763-70. PMID: 21940426
MH  - Health Policy
MH  - Humans
MH  - *Kidney Transplantation
MH  - Living Donors/*supply & distribution
MH  - Policy Making
MH  - Tissue and Organ Procurement/*economics/ethics
MH  - United States
EDAT- 2011/09/24 06:00
MHDA- 2012/01/18 06:00
CRDT- 2011/09/24 06:00
PHST- 2011/09/24 06:00 [entrez]
PHST- 2011/09/24 06:00 [pubmed]
PHST- 2012/01/18 06:00 [medline]
AID - 36/4/717 [pii]
AID - 10.1215/03616878-1334695 [doi]
PST - ppublish
SO  - J Health Polit Policy Law. 2011 Aug;36(4):717-55. doi: 10.1215/03616878-1334695.


PMID- 21940423
OWN - NLM
STAT- MEDLINE
DCOM- 20120117
LR  - 20110923
IS  - 1527-1927 (Electronic)
IS  - 0361-6878 (Linking)
VI  - 36
IP  - 4
DP  - 2011 Aug
TI  - Laypeople's ethical concerns about a New Israeli organ transplantation
      prioritization policy aimed to encourage organ donor registration among the
      public.
PG  - 691-716
LID - 10.1215/03616878-1334686 [doi]
AB  - A new policy recently enacted in Israel promises preferred status in receiving
      organs for transplantation to individuals who register to be organ donors and to 
      their close family members. Proponents believe it will increase the supply of
      organs for transplantation from the deceased. Ethical issues were raised in
      government committees appointed to discuss the policy before its approval, but
      discussions among laypeople were not solicited. This study aimed to elicit
      laypeople's views about the policy by conducting thirteen group interviews and
      thirty-six individual interviews. Participants included religious and
      nonreligious people, immigrants, and Arabs. Some participants thought the law
      would contribute to fairness by prioritizing those willing to give, but others
      articulated ethical concerns that were not emphasized by scholars, in particular 
      that the policy would add to the erosion of social solidarity, increase
      divisiveness, and enable people to abuse the system. Mistrust in the health care 
      system emerged as a prominent reason for not registering as an organ donor.
      Implications about the importance of transparency in the organ transplantation
      system as a basis for an information campaign, social norms regarding organ
      donation, and the public's involvement in policy issues on organ donation are
      discussed.
FAU - Guttman, Nurit
AU  - Guttman N
AD  - Tel Aviv University.
FAU - Ashkenazi, Tamar
AU  - Ashkenazi T
FAU - Gesser-Edelsburg, Anat
AU  - Gesser-Edelsburg A
FAU - Seidmann, Vered
AU  - Seidmann V
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Health Polit Policy Law
JT  - Journal of health politics, policy and law
JID - 7609331
SB  - IM
MH  - *Attitude to Health
MH  - *Health Policy
MH  - Health Priorities
MH  - Humans
MH  - Israel
MH  - Organ Transplantation
MH  - *Public Opinion
MH  - Tissue Donors
MH  - Tissue and Organ Procurement/*ethics
EDAT- 2011/09/24 06:00
MHDA- 2012/01/18 06:00
CRDT- 2011/09/24 06:00
PHST- 2011/09/24 06:00 [entrez]
PHST- 2011/09/24 06:00 [pubmed]
PHST- 2012/01/18 06:00 [medline]
AID - 36/4/691 [pii]
AID - 10.1215/03616878-1334686 [doi]
PST - ppublish
SO  - J Health Polit Policy Law. 2011 Aug;36(4):691-716. doi: 10.1215/03616878-1334686.


PMID- 21940195
OWN - NLM
STAT- MEDLINE
DCOM- 20120816
LR  - 20120207
IS  - 1873-2054 (Electronic)
IS  - 1353-8292 (Linking)
VI  - 18
IP  - 2
DP  - 2012 Mar
TI  - Place-focused physical activity research, human agency, and social justice in
      public health: taking agency seriously in studies of the built environment.
PG  - 172-9
LID - 10.1016/j.healthplace.2011.08.019 [doi]
AB  - Built environment characteristics have been linked to health outcomes and health 
      disparities. However, the effects of an environment on behavior may depend on
      human perception, interpretation, motivation, and other forms of human agency. We
      draw on epidemiological and ethical concepts to articulate a critique of research
      on the built environment and physical activity. We identify problematic
      assumptions and enumerate both scientific and ethical reasons to incorporate
      subjective perspectives and public engagement strategies into built environment
      research and interventions. We maintain that taking agency seriously is essential
      to the pursuit of health equity and the broader demands of social justice in
      public health, an important consideration as studies of the built environment and
      physical activity increasingly focus on socially disadvantaged communities.
      Attention to how people understand their environment and navigate competing
      demands can improve the scientific value of ongoing efforts to promote active
      living and health, while also better fulfilling our ethical obligations to the
      individuals and communities whose health we strive to protect.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Blacksher, Erika
AU  - Blacksher E
AD  - University of Washington School of Medicine, Department of Bioethics and
      Humanities, USA. EB2010@u.washington.edu
FAU - Lovasi, Gina S
AU  - Lovasi GS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110910
PL  - England
TA  - Health Place
JT  - Health & place
JID - 9510067
MH  - *Environment Design
MH  - Female
MH  - *Human Characteristics
MH  - Humans
MH  - Male
MH  - *Motor Activity
MH  - *Public Health
MH  - Research
MH  - *Residence Characteristics
MH  - *Social Justice
EDAT- 2011/09/24 06:00
MHDA- 2012/08/17 06:00
CRDT- 2011/09/24 06:00
PHST- 2011/04/06 00:00 [received]
PHST- 2011/08/26 00:00 [revised]
PHST- 2011/08/30 00:00 [accepted]
PHST- 2011/09/24 06:00 [entrez]
PHST- 2011/09/24 06:00 [pubmed]
PHST- 2012/08/17 06:00 [medline]
AID - S1353-8292(11)00159-6 [pii]
AID - 10.1016/j.healthplace.2011.08.019 [doi]
PST - ppublish
SO  - Health Place. 2012 Mar;18(2):172-9. doi: 10.1016/j.healthplace.2011.08.019. Epub 
      2011 Sep 10.


PMID- 21939626
OWN - NLM
STAT- MEDLINE
DCOM- 20120619
LR  - 20220311
IS  - 1873-1570 (Electronic)
IS  - 0300-9572 (Linking)
VI  - 83
IP  - 3
DP  - 2012 Mar
TI  - Randomised study of hypertonic saline infusion during resuscitation from
      out-of-hospital cardiac arrest.
PG  - 347-52
LID - 10.1016/j.resuscitation.2011.09.005 [doi]
AB  - AIM OF THE STUDY: Animal models of hypertonic saline infusion during
      cardiopulmonary resuscitation (CPR) improve survival, as well as myocardial and
      cerebral perfusion during CPR. We studied the effect of hypertonic saline
      infusion during CPR (Guidelines 2000) on survival to hospital admission and
      hospital discharge, and neurological outcome on hospital discharge. METHODS: The 
      study was performed by the EMS of Bonn, Germany, with ethical committee approval.
      Study inclusion criteria were non-traumatic out-of-hospital cardiac arrest, aged 
      18-80 years, and given of adrenaline (epinephrine) during CPR. Patients were
      randomly infused 2 mlkg(-1) HHS (7.2% NaCl with 6% hydroxyethyl starch
      200,000/0.5 [HES]) or HES over 10 min. RESULTS: 203 patients were randomised
      between May 2001 and June 2004. After HHS infusion, plasma sodium concentration
      increased significantly to 162+/-36 mmoll(-1) at 10 min after infusion and
      decreased to near normal (144+/-6 mmoll(-1)) at hospital admission. Survival to
      hospital admission and hospital discharge was similar in both groups (50/100 HHS 
      vs. 49/103 HES for hospital admission, 23/100 HHS vs. 22/103 HES for hospital
      discharge). There was a small improvement in neurological outcome in survivors on
      discharge (cerebral performance category 1 or 2) in the HHS group compared to the
      HES group (13/100 HHS vs. 5/100 HES, p<0.05, odds-ratio 2.9, 95% confidence
      interval 1.004-8.5). CONCLUSION: Hypertonic saline infusion during CPR using
      Guidelines 2000 did not improve survival to hospital admission or hospital
      discharge. There was a small improvement with hypertonic saline in the secondary 
      endpoint of neurological outcome on discharge in survivors. Further adequately
      powered studies using current guidelines are needed.
CI  - Copyright A(c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Breil, Martin
AU  - Breil M
AD  - Department of Anaesthesiology and Intensive Care Medicine, University Hospital of
      Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany. martin.breil@ukb.uni-bonn.de
FAU - Krep, Henning
AU  - Krep H
FAU - Heister, Ulli
AU  - Heister U
FAU - Bartsch, Andreas
AU  - Bartsch A
FAU - Bender, Raphael
AU  - Bender R
FAU - Schaefers, Bernadette
AU  - Schaefers B
FAU - Hoeft, Andreas
AU  - Hoeft A
FAU - Fischer, Matthias
AU  - Fischer M
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20110919
PL  - Ireland
TA  - Resuscitation
JT  - Resuscitation
JID - 0332173
RN  - 0 (Saline Solution, Hypertonic)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cardiopulmonary Resuscitation/*methods
MH  - Chi-Square Distribution
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Out-of-Hospital Cardiac Arrest/*therapy
MH  - Saline Solution, Hypertonic/*administration & dosage
MH  - Survival Rate
MH  - Treatment Outcome
EDAT- 2011/09/24 06:00
MHDA- 2012/06/20 06:00
CRDT- 2011/09/24 06:00
PHST- 2011/05/18 00:00 [received]
PHST- 2011/08/29 00:00 [revised]
PHST- 2011/09/02 00:00 [accepted]
PHST- 2011/09/24 06:00 [entrez]
PHST- 2011/09/24 06:00 [pubmed]
PHST- 2012/06/20 06:00 [medline]
AID - S0300-9572(11)00530-2 [pii]
AID - 10.1016/j.resuscitation.2011.09.005 [doi]
PST - ppublish
SO  - Resuscitation. 2012 Mar;83(3):347-52. doi: 10.1016/j.resuscitation.2011.09.005.
      Epub 2011 Sep 19.


PMID- 21939486
OWN - NLM
STAT- MEDLINE
DCOM- 20120110
LR  - 20110923
IS  - 1440-172X (Electronic)
IS  - 1322-7114 (Linking)
VI  - 17
IP  - 5
DP  - 2011 Oct
TI  - Tobacco and media exposure in poor neighbourhoods: implications for the incidence
      of smoking among community residents.
PG  - 534-8
LID - 10.1111/j.1440-172X.2011.01960.x [doi]
AB  - It is an accepted truth that tobacco, as well as second-hand smoke, causes lung
      and other cancers. This health policy fact sheet examines the need and
      implications for tobacco control legislation in the United States. Major
      stakeholders and special interest groups influence whether or not further tobacco
      control legislation can be passed and who it affects. This paper will review not 
      only the ethical implications, such as the ethical theory, ethical principles and
      ethical rules of conduct that support tobacco control legislation, but also its
      legal and economic implications as well as media influences. This paper concludes
      with the authors' assessment that the United States is in fact in need of more
      tobacco control legislation.
CI  - (c) 2011 Blackwell Publishing Asia Pty Ltd.
FAU - Weeks, Maureen O
AU  - Weeks MO
AD  - Department of Nursing, University of Massachusetts Boston, Boston, Massachusetts 
      02124, USA. mauzie@aol.com
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Int J Nurs Pract
JT  - International journal of nursing practice
JID - 9613615
MH  - Humans
MH  - Incidence
MH  - *Mass Media
MH  - *Poverty
MH  - Smoking/*epidemiology
MH  - *Tobacco
MH  - United States/epidemiology
EDAT- 2011/09/24 06:00
MHDA- 2012/01/11 06:00
CRDT- 2011/09/24 06:00
PHST- 2011/09/24 06:00 [entrez]
PHST- 2011/09/24 06:00 [pubmed]
PHST- 2012/01/11 06:00 [medline]
AID - 10.1111/j.1440-172X.2011.01960.x [doi]
PST - ppublish
SO  - Int J Nurs Pract. 2011 Oct;17(5):534-8. doi: 10.1111/j.1440-172X.2011.01960.x.


PMID- 21939406
OWN - NLM
STAT- MEDLINE
DCOM- 20111202
LR  - 20110923
IS  - 1360-0451 (Electronic)
IS  - 0954-0121 (Linking)
VI  - 23
IP  - 10
DP  - 2011 Oct
TI  - Implementing routine provider-initiated HIV testing in public health care
      facilities in Kenya: a qualitative descriptive study of nurses' experiences.
PG  - 1291-7
LID - 10.1080/09540121.2011.555751 [doi]
AB  - Routine "provider-initiated testing and counselling" (PITC) for HIV has been
      implemented amidst concern over how consent, confidentiality and counselling (the
      3Cs) can be maintained in under-resourced health care settings. In Kenya, PITC
      has been rolled out since 2005, HIV prevalence is 7.1% and more than 86% of
      adults have not been tested. Kenyan nurses are the main cadre implementing PITC, 
      but little is known about their experiences of incorporating HIV testing into
      everyday practice and the challenges faced in maintaining the 3Cs within their
      work environments. This study aimed to explore these issues and adopted a
      qualitative multi-method design using a convenience sampling approach. Two focus 
      group discussions (total n=12) and 13 in-depth individual interviews were
      undertaken with nurses from 11 different public health care facilities in Nairobi
      and its surrounding areas (including in-patient and outpatient settings). Data
      were analysed thematically. Nurses identified a range of personal, client and
      health system challenges in the everyday application of PITC. These included (i) 
      the contradictions of normalising a highly stigmatised disease and the difficulty
      in providing client-centred care within a routinised and target-oriented work
      culture; (ii) the challenge of dealing with ethically complex client situations
      in which the principles of the 3Cs could be difficult to uphold; and (iii) lack
      of time, resources, space and recognition within workplace environments
      (especially in-patient settings) that, likewise, led to problems with maintaining
      the 3Cs. In-patient nurses in particular identified problems associated with
      testing in a multi-disciplinary context, suggesting that other health
      professionals appeared to routinely flout the PITC guidelines. In conclusion,
      this study shows that the process of translating policy into practice is
      invariably complex and that more research is needed to explore PITC practices,
      particularly in in-patient settings. Nurses require supervision and support to
      negotiate the challenges and to fulfil their roles effectively.
FAU - Evans, Catrin
AU  - Evans C
AD  - School of Nursing, Midwifery and Physiotherapy, University of Nottingham, Queens 
      Medical Centre, UK. catrin.evans@nottingham.ac.uk
FAU - Ndirangu, Eunice
AU  - Ndirangu E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110621
PL  - England
TA  - AIDS Care
JT  - AIDS care
JID - 8915313
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Confidentiality
MH  - Counseling
MH  - Female
MH  - Focus Groups
MH  - HIV Infections/*diagnosis
MH  - Humans
MH  - Informed Consent
MH  - Kenya
MH  - Male
MH  - Mass Screening/*methods
MH  - Middle Aged
MH  - Nurses/*psychology
MH  - Qualitative Research
EDAT- 2011/09/24 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/09/24 06:00
PHST- 2011/09/24 06:00 [entrez]
PHST- 2011/09/24 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1080/09540121.2011.555751 [doi]
PST - ppublish
SO  - AIDS Care. 2011 Oct;23(10):1291-7. doi: 10.1080/09540121.2011.555751. Epub 2011
      Jun 21.


PMID- 21939123
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20110923
IS  - 0017-7768 (Print)
IS  - 0017-7768 (Linking)
VI  - 150
IP  - 8
DP  - 2011 Aug
TI  - [Complementary medicine--Jewish medical ethics].
PG  - 672-5, 686
AB  - In Israel, as in the Western world, the use of different methods of complementary
      and alternative medicine ICAM) is spreading. CAM raises ethical questions of
      concern to healthcare providers and to the public: Can physicians recommend a
      treatment that has no scientific evidence? Should the government include such
      therapies in the health budget? Can complementary therapists receive protection
      against lawsuits if their treatment is recognized? The purpose of this article is
      to present a Jewish perspective on these issues. The fundamental sources that
      deal with the subject are based on the approach of rabbinic authorities toward
      unproven medicine, as expressed in the "Mishnah" and "Talmud" (200-500 C.E). The 
      great Jewish scholar who discusses the subject in detail is Maimonides
      (1135-1204), who defines what "medicine" is and claims that medicine has to rely 
      on reason or experience. Contemporary Jewish commentators present their position 
      based on the interpretation of Maimonides' texts. In this article we claim that
      treatments can be divided into four groups, each group having a different
      halachic status: (1) Treatment that might be dangerous--should not be used. (2)
      Treatment that is safe--can be used, but has no other special status. (3)
      Treatment recognized by alternative therapists--has consequences for the
      observant Jew, such as laws of Kashrut and Shabbat. (4) Treatment that was tested
      and proven using modern medical methods has public significance--the therapist is
      entitled to legal defense if he made a reasonable mistake; the government can
      consider funding such treatment using public money. This article presents the
      Jewish halachic sources upon which we propose an ethical-practical approach to
      CAM.
FAU - Katz, Yisrae
AU  - Katz Y
AD  - Clalit Health Services, Jerusalem District, Israel. Yshkatz@gmail.com
FAU - Schiff, Elad
AU  - Schiff E
LA  - heb
PT  - English Abstract
PT  - Journal Article
PL  - Israel
TA  - Harefuah
JT  - Harefuah
JID - 0034351
SB  - IM
MH  - Complementary Therapies/adverse effects/*ethics/legislation & jurisprudence
MH  - *Ethics, Medical
MH  - Humans
MH  - Israel
MH  - *Judaism
MH  - Religion and Medicine
EDAT- 2011/09/24 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/09/24 06:00
PHST- 2011/09/24 06:00 [entrez]
PHST- 2011/09/24 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
PST - ppublish
SO  - Harefuah. 2011 Aug;150(8):672-5, 686.


PMID- 21939117
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20121115
IS  - 0017-7768 (Print)
IS  - 0017-7768 (Linking)
VI  - 150
IP  - 8
DP  - 2011 Aug
TI  - [Complementary and alternative medicine--time for research and regulation].
PG  - 655-6, 688
AB  - The usage of complementary and alternative medicine [CAM] is increasing in
      popularity in the modern world. In this issue of Harefuah, seven articles relate 
      to various aspects of CAM: the use of various modalities of CAM in four community
      clinics in Northern Israel, an assessment of the needs and expectations of
      patients on chemotherapy from the integration of CAM in palliative oncological
      care, a description of a series of quality research studies relating to CAM in
      hemato-oncological disorders and autoimmune diseases and a discussion of ethical 
      dilemmas and issues relating to Jewish law. Other authors review the history of
      clinical studies with an emphasis on mind-body connection and the placebo effect.
      The conclusion that may be derived about CAM from this compilation of articles is
      that, despite the ltack of scientific evidence to support the paradigm underlying
      most CAM modalities and the scarcity of evidence to support its efficacy, the
      increasing popularity of CAM should lead us to expand research into CAM and to
      teach our medical students about CAM. We should do so for the sake of proper
      doctor-patient relationships and to prevent improper use of CAM by the general
      public. The diversity of CAM modalities and the heterogeneity of training
      patterns among those who practice CAM call for the prompt regulation of training 
      and licensing of all CAM practitioners.
FAU - Halevy, Jonathan
AU  - Halevy J
LA  - heb
PT  - Editorial
PT  - English Abstract
PL  - Israel
TA  - Harefuah
JT  - Harefuah
JID - 0034351
SB  - IM
MH  - Complementary Therapies/education/methods/*trends
MH  - Delivery of Health Care, Integrated/organization & administration
MH  - Evidence-Based Medicine
MH  - Humans
MH  - Israel
MH  - *Physician-Patient Relations
MH  - *Research Design
EDAT- 2011/09/24 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/09/24 06:00
PHST- 2011/09/24 06:00 [entrez]
PHST- 2011/09/24 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
PST - ppublish
SO  - Harefuah. 2011 Aug;150(8):655-6, 688.


PMID- 21938998
OWN - NLM
STAT- MEDLINE
DCOM- 20111027
LR  - 20110923
IS  - 0945-1129 (Print)
IS  - 0945-1129 (Linking)
VI  - 64
IP  - 9
DP  - 2011 Sep
TI  - [Ethical uncertainty about the end of life. The is no obligation to live].
PG  - 524-7
FAU - Kress, Hartmut
AU  - Kress H
AD  - Evange-lish-Theologischen Fakultat der Universitat Bonn, Bonn. hkress@uni-bonn.de
LA  - ger
PT  - Journal Article
TT  - Ethischer Zweifel angesichts des Lebensendes. Es gibt keine Lebenspflicht.
PL  - Germany
TA  - Pflege Z
JT  - Pflege Zeitschrift
JID - 9430463
CIN - Pflege Z. 2011 Sep;64(9):513. PMID: 21938995
MH  - Conscious Sedation/ethics/nursing
MH  - *Ethics, Medical
MH  - *Ethics, Nursing
MH  - Germany
MH  - Humans
MH  - Living Wills/*ethics/*legislation & jurisprudence
MH  - Palliative Care/*ethics/*legislation & jurisprudence
MH  - *Personal Autonomy
MH  - Suicide, Assisted/*ethics/*legislation & jurisprudence
MH  - Terminal Care/*ethics/*legislation & jurisprudence
MH  - *Uncertainty
EDAT- 2011/09/24 06:00
MHDA- 2011/10/28 06:00
CRDT- 2011/09/24 06:00
PHST- 2011/09/24 06:00 [entrez]
PHST- 2011/09/24 06:00 [pubmed]
PHST- 2011/10/28 06:00 [medline]
PST - ppublish
SO  - Pflege Z. 2011 Sep;64(9):524-7.


PMID- 21938898
OWN - NLM
STAT- MEDLINE
DCOM- 20111011
LR  - 20151119
IS  - 0026-9050 (Print)
IS  - 0026-9050 (Linking)
VI  - 332
IP  - 7
DP  - 2011 Jul
TI  - [Features of the organization and algorithms of actions of forensic experts in
      emergencies and military conflicts].
PG  - 25-9
AB  - The article deals with the problem of identification of unidentified dead bodies 
      in emergency situations with mass casualties. The basic principles of forensic
      identification are regulatory and legal regulation, the types, methods and
      algorithm implementation. Solving of the problem of identification because of its
      great social, moral, ethical and political morality is an important public policy
      issue. It is emphasized the importance of an adequate regulatory framework in
      relation to objects and subjects of the identification and regulation of
      algorithms of actions forensic experts.
FAU - Stepanov, A A
AU  - Stepanov AA
FAU - Pinchuk, P V
AU  - Pinchuk PV
LA  - rus
PT  - English Abstract
PT  - Journal Article
PL  - Russia (Federation)
TA  - Voen Med Zh
JT  - Voenno-meditsinskii zhurnal
JID - 2984871R
SB  - IM
MH  - *Algorithms
MH  - Forensic Medicine/*organization & administration/*standards
MH  - Humans
MH  - *Warfare
EDAT- 2011/09/24 06:00
MHDA- 2011/10/12 06:00
CRDT- 2011/09/24 06:00
PHST- 2011/09/24 06:00 [entrez]
PHST- 2011/09/24 06:00 [pubmed]
PHST- 2011/10/12 06:00 [medline]
PST - ppublish
SO  - Voen Med Zh. 2011 Jul;332(7):25-9.


PMID- 21938893
OWN - NLM
STAT- MEDLINE
DCOM- 20111011
LR  - 20191112
IS  - 0022-2917 (Print)
IS  - 0022-2917 (Linking)
VI  - 48
IP  - 2
DP  - 2011 Summer
TI  - Personal therapy for undergraduate music therapy students: a survey of AMTA
      program coordinators.
PG  - 226-55
AB  - The primary purpose of this study was to gather information in order to
      understand if and how various modalities of personal therapy are employed with
      undergraduate music therapy students in the United States. AMTA degree program
      coordinators were asked about 3 therapy modalities, in particular: verbal
      therapy, music therapy, and expressive arts therapy (excluding music therapy). It
      was predicted that less than a quarter of the respondents would indicate that
      personal therapy of any modality was required in their undergraduate curricula,
      but that a larger percentage would indicate that it was encouraged. Both
      hypotheses were supported, with just over 14% of the respondents indicating that 
      they require some form of personal therapy and 32% indicating that they encourage
      it, with 73% of this latter subgroup encouraging verbal therapy and 46%
      encouraging music therapy. It was further predicted that, when therapy was
      required or encouraged, it was most often provided by an individual who was
      associated with the college/university and that therapy was usually provided in a
      group format. Respondent comments related to these 2 questions revealed
      considerable confusion between experiential exercises and personal therapy,
      leading to dubious validity of some of the numerical data. Qualitative treatment 
      of narrative responses illuminated 4 salient issues regarding personal therapy
      for undergraduate music therapy students, as follows: (a) the legal and ethical
      feasibility of making personal therapy a requirement; (b) the cost and
      availability of qualified professionals; (c) the benefits of personal therapy as 
      an integral facet of undergraduate music therapy training and education; and (d) 
      the appropriateness of personal therapy at the undergraduate level of training.
FAU - Gardstrom, Susan C
AU  - Gardstrom SC
AD  - University of Dayton, USA.
FAU - Jackson, Nancy A
AU  - Jackson NA
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Music Ther
JT  - Journal of music therapy
JID - 0014162
SB  - IM
MH  - Faculty/*statistics & numerical data
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - *Interprofessional Relations
MH  - Mentors/*statistics & numerical data
MH  - Music Therapy/*education/*methods
MH  - Population Surveillance
MH  - Students, Health Occupations/*statistics & numerical data
MH  - Surveys and Questionnaires
MH  - United States
EDAT- 2011/09/24 06:00
MHDA- 2011/10/12 06:00
CRDT- 2011/09/24 06:00
PHST- 2011/09/24 06:00 [entrez]
PHST- 2011/09/24 06:00 [pubmed]
PHST- 2011/10/12 06:00 [medline]
AID - 10.1093/jmt/48.2.226 [doi]
PST - ppublish
SO  - J Music Ther. 2011 Summer;48(2):226-55. doi: 10.1093/jmt/48.2.226.


PMID- 21938513
OWN - NLM
STAT- MEDLINE
DCOM- 20111202
LR  - 20211020
IS  - 1573-3394 (Electronic)
IS  - 1065-3058 (Linking)
VI  - 19
IP  - 3
DP  - 2011 Sep
TI  - Accountability, governance and biobanks: the ethics and governance committee as
      guardian or as toothless tiger?
PG  - 231-46
LID - 10.1007/s10728-011-0195-7 [doi]
AB  - The huge potential of biobanks/genetic databases for the research community has
      been recognised across jurisdictions in both publicly funded and commercial
      sectors. But although there is tremendous potential there are likewise potential 
      difficulties. The long-term storage of personal health information and samples
      poses major challenges. This is an area is fraught with ethical and legal
      uncertainties. Biobanks raise many questions of the control of rights, of
      consent, of privacy and confidentiality and of property in human material. It is 
      thus unsurprising then that there has been a lively debate as to how biobanks
      should operate, the boundaries of participation and what governance structure, if
      any they should adopt, a debate which has been engaged in across the academic
      community and by funders and researchers alike. This paper asks despite the good 
      intentions can ad hoc ethics and ethics and governance committees long term
      provide an effective solution to the legal and regulatory challenges arising from
      biobanks.
FAU - McHale, Jean V
AU  - McHale JV
AD  - Birmingham Law School, University of Birmingham, UK. j.v.mchale@bham.ac.uk
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Health Care Anal
JT  - Health care analysis : HCA : journal of health philosophy and policy
JID - 9432537
MH  - Biological Specimen Banks/*ethics/legislation & jurisprudence
MH  - Confidentiality/ethics/legislation & jurisprudence
MH  - *Ethics Committees, Research
MH  - Genetic Research/*ethics/legislation & jurisprudence
MH  - Humans
MH  - Informed Consent/ethics/legislation & jurisprudence
MH  - Social Responsibility
MH  - United Kingdom
EDAT- 2011/09/23 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/09/23 06:00
PHST- 2011/09/23 06:00 [entrez]
PHST- 2011/09/23 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/s10728-011-0195-7 [doi]
PST - ppublish
SO  - Health Care Anal. 2011 Sep;19(3):231-46. doi: 10.1007/s10728-011-0195-7.


PMID- 21938503
OWN - NLM
STAT- MEDLINE
DCOM- 20120517
LR  - 20211020
IS  - 1437-1596 (Electronic)
IS  - 0937-9827 (Linking)
VI  - 126
IP  - 1
DP  - 2012 Jan
TI  - Journals publishing bio-medicolegal research in Europe.
PG  - 129-37
LID - 10.1007/s00414-011-0620-3 [doi]
AB  - Fragmentation of bio-medicolegal knowledge has led to a proliferation of
      ultra-specialised sub-disciplines and branches, often published in
      'field-oriented' scientific journals.The aim of this work is to provide an
      in-depth analytical picture of bio-medicolegal sources of publication, within and
      outside the traditional conception of legal medicine. An extensive search of
      bio-medicolegal articles published in the last five and a half years was
      performed on the MEDLINE database according to MeSH terms combined with free-text
      protocols. We performed a systematic analysis of targeted journals after merging,
      selecting and categorising all retrieved records, taking into account data from
      the 2009 JCR Science Edition (released on June 2010); 1,037 different journals
      were identified, of which only 48 (4.6%) focus specifically on bio-medicolegal
      matters, and of which only seven (14.6%) have an impact factor (IF). Despite this
      apparent dispersion, 47% of articles were published in bio-medicolegal journals
      (BML), of which 70.2% were in journals with IF (BML-IF). Articles published in
      BML-IF journals (33% of total papers) reach almost 50%, mainly in "Forensic
      Science International", "International Journal of Legal Medicine" and "Journal of
      Forensic Sciences". Instead, publications in not specifically bio-medicolegal
      journals (Not BML-IF) are greatly scattered and even fragmented in about 650
      journals.The sub-disciplines that appear most frequently in Not BML-IF rather
      than BML-IF journals are Forensic Psychiatry (48.2% vs. 5.1%), Criminology (37.1%
      vs. 8.3%), Malpractice (50.7% vs. 4.0%), Medical Law and Ethics (46.4% vs. 6.9%) 
      and Clinical Forensic Medicine (39.5% vs. 21.3%). The proposed bibliometric
      analysis revealed the preference of Forensic Pathology, Criminalistics
      (Biological), Forensic Genetics, Forensic Anthropology and Forensic Entomology
      for journals traditionally considered pertinent to the medico-legal discipline,
      with a considerable dispersion involving Toxicology, Psychiatry, Criminology and 
      Malpractice, which were published in less well-known journals. This dispersion
      could be reduced adapting specialised forensic sections and increasing the IF of 
      forensic journals, in order to respond suitably to the present demand for
      visibility by bio-medicolegal scientists, clearly oriented towards enhancing the 
      objective impact of their curricula and attempting to attract funding to their
      research projects.
FAU - Boscolo-Berto, Rafael
AU  - Boscolo-Berto R
AD  - Department of Environmental Medicine and Public Health, Institute of Legal
      Medicine, University Hospital of Padova, Padova, Italy.
FAU - Viel, Guido
AU  - Viel G
FAU - Cecchi, Rossana
AU  - Cecchi R
FAU - Terranova, Claudio
AU  - Terranova C
FAU - Vogliardi, Susanna
AU  - Vogliardi S
FAU - Bajanowski, Thomas
AU  - Bajanowski T
FAU - Ferrara, Santo Davide
AU  - Ferrara SD
LA  - eng
PT  - Journal Article
DEP - 20110922
PL  - Germany
TA  - Int J Legal Med
JT  - International journal of legal medicine
JID - 9101456
SB  - IM
MH  - *Bibliometrics
MH  - Europe
MH  - *Forensic Sciences
MH  - Humans
MH  - *Periodicals as Topic
EDAT- 2011/09/23 06:00
MHDA- 2012/05/18 06:00
CRDT- 2011/09/23 06:00
PHST- 2011/06/29 00:00 [received]
PHST- 2011/09/05 00:00 [accepted]
PHST- 2011/09/23 06:00 [entrez]
PHST- 2011/09/23 06:00 [pubmed]
PHST- 2012/05/18 06:00 [medline]
AID - 10.1007/s00414-011-0620-3 [doi]
PST - ppublish
SO  - Int J Legal Med. 2012 Jan;126(1):129-37. doi: 10.1007/s00414-011-0620-3. Epub
      2011 Sep 22.


PMID- 21938334
OWN - NLM
STAT- MEDLINE
DCOM- 20140113
LR  - 20150722
IS  - 2364-0502 (Electronic)
IS  - 0943-4747 (Linking)
VI  - 6
DP  - 2011
TI  - Health Informatics 3.0 and other increasingly dispersed technologies require even
      greater trust: promoting safe evidence-based health informatics. Contribution of 
      the IMIA Working Group on Technology Assessment & Quality Development in Health
      Informatics.
PG  - 105-11
AB  - BACKGROUND: Health informatics is generally less committed to a scientific
      evidence-based approach than any other area of health science, which is an
      unsound position. Introducing the new Web 3.0 paradigms into health IT
      applications can unleash a further great potential, able to integrate and
      distribute data from multiple sources. The counter side is that it makes the user
      and the patient evermore dependent on the 'black box' of the system, and the
      re-use of the data remote from the author and initial context. Thus anticipatory 
      consideration of uses, and proactive analysis of evidence of effects, are
      imperative, as only when a clinical technology can be proven to be trustworthy
      and safe should it be implemented widely - as is the case with other health
      technologies. OBJECTIVES: To argue for promoting evidence-based health
      informatics as systems become more powerful and pro-active yet more dispersed and
      remote; and evaluation as the means of generating the necessary scientific
      evidence base. To present ongoing IMIA and EFMI initiatives in this field.
      METHODS: Critical overview of recent developments in health informatics
      evaluation, alongside the precedents of other health technologies, summarising
      current initiatives and the new challenges presented by Health Informatics 3.0.
      RESULTS: Web 3.0 should be taken as an opportunity to move health informatics
      from being largely unaccountable to one of being an ethical and responsible
      science-based domain. Recent and planned activities of the EFMI and IMIA working 
      groups have significantly progressed key initiatives. CONCLUSIONS: Concurrent
      with the emergence of Web 3.0 as a means of new-generation diffuse health
      information systems comes an increasing need for an evidence-based culture in
      health informatics.
FAU - Rigby, M
AU  - Rigby M
AD  - Keele University, School of Public Policy and Professional Practice, Keele,
      United Kingdom.
FAU - Ammenwerth, E
AU  - Ammenwerth E
FAU - Talmon, J
AU  - Talmon J
FAU - Nykanen, P
AU  - Nykanen P
FAU - Brender, J
AU  - Brender J
FAU - de Keizer, N
AU  - de Keizer N
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Yearb Med Inform
JT  - Yearbook of medical informatics
JID - 9312666
SB  - IM
MH  - *Evidence-Based Practice
MH  - *Internet
MH  - Medical Informatics/*standards
EDAT- 2011/09/23 06:00
MHDA- 2014/01/15 06:00
CRDT- 2011/09/23 06:00
PHST- 2011/09/23 06:00 [entrez]
PHST- 2011/09/23 06:00 [pubmed]
PHST- 2014/01/15 06:00 [medline]
AID - me11010105 [pii]
PST - ppublish
SO  - Yearb Med Inform. 2011;6:105-11.


PMID- 21938049
OWN - NLM
STAT- MEDLINE
DCOM- 20111103
LR  - 20181201
IS  - 1476-4687 (Electronic)
IS  - 0028-0836 (Linking)
VI  - 477
IP  - 7365
DP  - 2011 Sep 21
TI  - Military robotics and ethics: a world of killer apps.
PG  - 399-401
LID - 10.1038/477399a [doi]
FAU - Singer, P W
AU  - Singer PW
AD  - Brookings Institution, Washington, DC 20036, USA.
LA  - eng
PT  - Journal Article
DEP - 20110921
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
SB  - IM
CIN - Nature. 2011 Sep 22;477(7365):369. PMID: 21938028
MH  - Codes of Ethics
MH  - Military Science/*ethics
MH  - Public Policy/legislation & jurisprudence
MH  - Robotics/*ethics/legislation & jurisprudence/*statistics & numerical data
MH  - Time Factors
MH  - Warfare/ethics
MH  - Weapons/*ethics/legislation & jurisprudence
EDAT- 2011/09/23 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/09/23 06:00
PHST- 2011/09/23 06:00 [entrez]
PHST- 2011/09/23 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
AID - 477399a [pii]
AID - 10.1038/477399a [doi]
PST - epublish
SO  - Nature. 2011 Sep 21;477(7365):399-401. doi: 10.1038/477399a.


PMID- 21937616
OWN - NLM
STAT- MEDLINE
DCOM- 20120221
LR  - 20211020
IS  - 1748-880X (Electronic)
IS  - 0007-1285 (Linking)
VI  - 85
IP  - 1009
DP  - 2012 Jan
TI  - Management of incidental findings during imaging research in "healthy"
      volunteers: current UK practice.
PG  - 11-21
LID - 10.1259/bjr/73283917 [doi]
AB  - OBJECTIVES: Incidental findings (IF) are becoming increasingly common due to the 
      proliferation of imaging research. IFs can be life-changing for "healthy"
      volunteers. This study examined variation in IF management in UK research studies
      of healthy volunteers, including comparison with ethical and legal guidelines,
      thus providing baseline data and informing future practice. METHODS:
      Questionnaire of participant background [medical/non-medical;
      radiologist/non-radiologist; years as principal investigator (PI)], type of
      research (involving children or not), institutional policy, volunteer
      information, radiologist involvement in reporting scans and IF disclosure
      mechanisms. Investigator's current and perceived "ideal" practice was examined.
      Participants were PIs performing imaging research of healthy volunteers approved 
      by UK ethics committees (2006-2009). RESULTS: 63/146 (43%) surveys completed.
      54/61 (88.5%) had site-specific guidelines. Information commonly provided to
      volunteers should IF be found: personal data (51/62; 82%), contingency plans
      (54/62; 87%) and disclosure to general practitioner (GP)/treating physician
      (47/62; 76%). PIs used different strategies for image review. Commonest:
      radiologist reports research scans only when researcher suspicious of IF [15/57
      (26%) compared with 5/28 (16%) in ideal practice]. Commonest ideal reporting
      strategy: routine reporting by specialist radiologists [9/28 (29%) compared with 
      8/57 (14%) in current practice]. 49/56 (87.5%) have a standardised disclosure
      contingency plan, usually involving GP. PIs most commonly disclosed IFs to
      volunteers when judged relevant (27/58; 47%), most commonly face to face (22/54; 
      41%), by volunteer's GP (26/60; 43%). Background of PI influenced consent,
      reporting and disclosure practice. CONCLUSION: There is wide variation in
      handling IFs in UK imaging research. Much of the current practice contravenes the
      vague existing legal and ethical guidelines, and is unlikely to be in the best
      interests of volunteers or researchers.
FAU - Booth, T C
AU  - Booth TC
AD  - Department of Biochemistry, University of Cambridge, Cambridge, UK.
FAU - Waldman, A D
AU  - Waldman AD
FAU - Wardlaw, J M
AU  - Wardlaw JM
FAU - Taylor, S A
AU  - Taylor SA
FAU - Jackson, A
AU  - Jackson A
LA  - eng
PT  - Journal Article
DEP - 20110921
PL  - England
TA  - Br J Radiol
JT  - The British journal of radiology
JID - 0373125
SB  - IM
MH  - *Healthy Volunteers
MH  - Human Experimentation
MH  - Humans
MH  - *Incidental Findings
MH  - Practice Patterns, Physicians'
MH  - *Radiography
MH  - Surveys and Questionnaires
MH  - United Kingdom
PMC - PMC3473920
EDAT- 2011/09/23 06:00
MHDA- 2012/02/22 06:00
CRDT- 2011/09/23 06:00
PHST- 2011/09/23 06:00 [entrez]
PHST- 2011/09/23 06:00 [pubmed]
PHST- 2012/02/22 06:00 [medline]
AID - 73283917 [pii]
AID - 10.1259/bjr/73283917 [doi]
PST - ppublish
SO  - Br J Radiol. 2012 Jan;85(1009):11-21. doi: 10.1259/bjr/73283917. Epub 2011 Sep
      21.


PMID- 21937564
OWN - NLM
STAT- MEDLINE
DCOM- 20120227
LR  - 20181023
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 343
DP  - 2011 Sep 21
TI  - Ethics committees: an ethical dilemma.
PG  - d6002
LID - 10.1136/bmj.d6002 [doi]
LID - bmj.d6002 [pii]
FAU - Spence, Des
AU  - Spence D
AD  - destwo@yahoo.co.uk
LA  - eng
PT  - Journal Article
DEP - 20110921
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
SB  - IM
CIN - BMJ. 2011;343:d6511. PMID: 21994307
MH  - Conflict of Interest
MH  - Ethics Committees, Research/*ethics
MH  - Humans
MH  - United Kingdom
EDAT- 2011/09/23 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/09/23 06:00
PHST- 2011/09/23 06:00 [entrez]
PHST- 2011/09/23 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - 10.1136/bmj.d6002 [doi]
PST - epublish
SO  - BMJ. 2011 Sep 21;343:d6002. doi: 10.1136/bmj.d6002.


PMID- 21937469
OWN - NLM
STAT- MEDLINE
DCOM- 20120103
LR  - 20110922
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 10
DP  - 2011 Oct
TI  - Specification and other methods for determining morally relevant facts.
PG  - 592-6
LID - 10.1136/jme.2010.039214 [doi]
AB  - Specification is an integral part of Tom L Beauchamp and James F Childress'
      principlist approach to biomedical ethics. At the same time, the authors give
      much space conceding to critics that the method has significant limits. Although 
      their pointing to limitations is not unreasonable as such, the emphasis Beauchamp
      and Childress put on them does not serve countering the critics' view that
      specification is insufficient for its intended purpose in applied ethics. This
      paper defends specification against Carson Strong's critique, showing that his
      casuistic approach shares strong structural and functional similarities with
      specification. It concludes with the more general point that specification or
      some closely related method for determining morally relevant facts of concrete
      cases and issues is indispensable for any account of applied ethics. Beauchamp
      and Childress should endorse and defend specification more vigorously than they
      appear to do.
FAU - Rauprich, Oliver
AU  - Rauprich O
AD  - Institute for Medical Ethics and History of Medicine, Ruhr-University Bochum,
      Markstrasse 258a, Bochum, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Bioethics
MH  - Cultural Characteristics
MH  - *Ethical Theory
MH  - Humans
MH  - *Morals
MH  - Personal Autonomy
MH  - *Principle-Based Ethics
MH  - Professional Autonomy
EDAT- 2011/09/23 06:00
MHDA- 2012/01/04 06:00
CRDT- 2011/09/23 06:00
PHST- 2011/09/23 06:00 [entrez]
PHST- 2011/09/23 06:00 [pubmed]
PHST- 2012/01/04 06:00 [medline]
AID - jme.2010.039214 [pii]
AID - 10.1136/jme.2010.039214 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Oct;37(10):592-6. doi: 10.1136/jme.2010.039214.


PMID- 21937468
OWN - NLM
STAT- MEDLINE
DCOM- 20120103
LR  - 20110922
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 10
DP  - 2011 Oct
TI  - A waste of time: the problem of common morality in Principles of Biomedical
      Ethics.
PG  - 588-91
LID - 10.1136/medethics-2011-100106 [doi]
AB  - From the 5th edition of Beauchamp and Childress' Principles of Biomedical Ethics,
      the problem of common morality has been given a more prominent role and emphasis.
      With the publication of the 6th and latest edition, the authors not only attempt 
      to ground their theory in common morality, but there is also an increased
      tendency to identify the former with the latter. While this stratagem may give
      the impression of a more robust, and hence stable, foundation for their
      theoretical construct, we fear that it comes with a cost, namely the need to keep
      any theory in medical ethics open to, and thereby aware of, the challenges
      arising from biomedical research and clinical practice, as well as healthcare
      systems. By too readily identifying the moral life of common morality with
      rule-following behaviour, Beauchamp and Childress may even be wrong about the
      nature of common morality as such, thereby founding their, by now, classic theory
      on quicksand instead of solid rock.
FAU - Karlsen, Jan Reinert
AU  - Karlsen JR
AD  - Centre for Medical Ethics, Institute of Health and Society, Blindern, Oslo,
      Norway.
FAU - Solbakk, Jan Helge
AU  - Solbakk JH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Bioethics
MH  - Cultural Characteristics
MH  - *Ethical Theory
MH  - Humans
MH  - *Morals
MH  - *Principle-Based Ethics
EDAT- 2011/09/23 06:00
MHDA- 2012/01/04 06:00
CRDT- 2011/09/23 06:00
PHST- 2011/09/23 06:00 [entrez]
PHST- 2011/09/23 06:00 [pubmed]
PHST- 2012/01/04 06:00 [medline]
AID - medethics-2011-100106 [pii]
AID - 10.1136/medethics-2011-100106 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Oct;37(10):588-91. doi: 10.1136/medethics-2011-100106.


PMID- 21937467
OWN - NLM
STAT- MEDLINE
DCOM- 20120103
LR  - 20110922
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 10
DP  - 2011 Oct
TI  - Determining the common morality's norms in the sixth edition of Principles of
      Biomedical Ethics.
PG  - 584-7
LID - 10.1136/jme.2009.030114 [doi]
AB  - Tom Beauchamp and James Childress have always maintained that their four
      principles approach (otherwise known as principlism) is a globally applicable
      framework for biomedical ethics. This claim is grounded in their belief that the 
      principles of respect for autonomy, non-maleficence, beneficence and justice form
      part of a 'common morality', or collection of very general norms to which
      everyone who is committed to morality subscribes. The difficulty, however, has
      always been how to demonstrate, at least in the absence of a full-blooded
      analysis of the concept of morality, whether the four principles are
      foundational, and so globally applicable, in this way. In the recently published 
      sixth edition of Principles of Biomedical Ethics, an imaginative and
      non-question-begging empirical method of determining the common morality's norms 
      is suggested. In this paper, I outline this method, before arguing that it is
      difficult to see how it might be thought to achieve its purpose.
FAU - Herissone-Kelly, Peter
AU  - Herissone-Kelly P
AD  - Philosophy Section, International School for Communities, Rights and Inclusion,
      University of Central Lancashire, Preston, UK. pnherissone-kelly@uclan.ac.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Bioethics
MH  - *Ethical Theory
MH  - Humans
MH  - *Morals
MH  - *Principle-Based Ethics
EDAT- 2011/09/23 06:00
MHDA- 2012/01/04 06:00
CRDT- 2011/09/23 06:00
PHST- 2011/09/23 06:00 [entrez]
PHST- 2011/09/23 06:00 [pubmed]
PHST- 2012/01/04 06:00 [medline]
AID - jme.2009.030114 [pii]
AID - 10.1136/jme.2009.030114 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Oct;37(10):584-7. doi: 10.1136/jme.2009.030114.


PMID- 21937466
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120103
LR  - 20110922
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 10
DP  - 2011 Oct
TI  - 30 Years Principles of biomedical ethics: introduction to a symposium on the 6th 
      edition of Tom L Beauchamp and James F Childress' seminal work.
PG  - 582-3
LID - 10.1136/jme.2010.039222rep [doi]
FAU - Rauprich, Oliver
AU  - Rauprich O
FAU - Vollmann, Jochen
AU  - Vollmann J
LA  - eng
PT  - Editorial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
RPF - J Med Ethics. 2011 Aug;37(8):454-5. PMID: 21772037
EDAT- 2011/09/23 06:00
MHDA- 2011/09/23 06:01
CRDT- 2011/09/23 06:00
PHST- 2011/09/23 06:00 [entrez]
PHST- 2011/09/23 06:00 [pubmed]
PHST- 2011/09/23 06:01 [medline]
AID - jme.2010.039222rep [pii]
AID - 10.1136/jme.2010.039222rep [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Oct;37(10):582-3. doi: 10.1136/jme.2010.039222rep.


PMID- 21937460
OWN - NLM
STAT- MEDLINE
DCOM- 20120213
LR  - 20110922
IS  - 1741-2811 (Electronic)
IS  - 1460-4582 (Linking)
VI  - 17
IP  - 3
DP  - 2011 Sep
TI  - Smarter elder care? A cost-effectiveness analysis of implementing technology in
      elder care.
PG  - 161-72
LID - 10.1177/1460458211409716 [doi]
AB  - Whereas in most sectors, technology has taken over trivial and labour consuming
      tasks, this transformation has been delayed in the healthcare sector. Although
      appropriate technology is available, there is general resistance to substituting 
      'warm' hands with 'cold' technology. In the future, this may change as the number
      of elderly people increases relative to the people in the work force. In
      combination with an increasing demand for healthcare services, there are calls
      for efforts to increase productivity in the sector. Based on experience data from
      previous studies on information and communication technology efforts in the
      healthcare sector, we quantitatively assess the use of smart house technology and
      video visits in home care. Having identified healthcare providers, hospitals and 
      relatives as the main affected groups, we show that smart house technology is
      cost-effective, even if only relatives gain from it. Video visits, which have
      higher implementation costs, demand effects on both relatives and health care
      providers in order to be a cost-effective tool in home care. As the analysis is
      purely quantitative, these results need to be complemented with qualitative
      effects and with more thorough discussions of the ethical, medical and legal
      aspects of the use of technology in home care.
FAU - Aanesen, Margrethe
AU  - Aanesen M
AD  - University of Tromso, Tromso Norway. margrethe.aanesen@uit.no
FAU - Lotherington, Ann Therese
AU  - Lotherington AT
FAU - Olsen, Frank
AU  - Olsen F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Health Informatics J
JT  - Health informatics journal
JID - 100883604
SB  - IM
MH  - Aged
MH  - Caregivers/economics
MH  - Chronic Disease/economics/therapy
MH  - Cost-Benefit Analysis
MH  - Disabled Persons
MH  - Geographic Information Systems/economics
MH  - Home Care Services/*economics
MH  - Humans
MH  - Microcomputers
MH  - Norway
MH  - Remote Consultation/*economics/*methods
EDAT- 2011/09/23 06:00
MHDA- 2012/02/14 06:00
CRDT- 2011/09/23 06:00
PHST- 2011/09/23 06:00 [entrez]
PHST- 2011/09/23 06:00 [pubmed]
PHST- 2012/02/14 06:00 [medline]
AID - 17/3/161 [pii]
AID - 10.1177/1460458211409716 [doi]
PST - ppublish
SO  - Health Informatics J. 2011 Sep;17(3):161-72. doi: 10.1177/1460458211409716.


PMID- 21937459
OWN - NLM
STAT- MEDLINE
DCOM- 20120524
LR  - 20120220
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 3
DP  - 2012 Mar
TI  - A syllabus for research ethics committees: training needs and resources in
      different European countries.
PG  - 184-6
LID - 10.1136/medethics-2011-100064 [doi]
AB  - This paper reports a European Forum for Good Clinical Practice workshop held in
      2011 to consider a research ethics committee training syllabus, subsequent
      training needs and resources. The syllabus that was developed was divided into
      four competencies: committee working; scientific method; ethical analysis and the
      regulatory framework. Appropriate training needs for each, with possible
      resources, were discussed. Lack of funding for training was reported as a major
      problem but affordable alternatives were debated. Strengths and weaknesses of
      this approach were discussed and the resultant proposal will be disseminated
      through the European Forum for Good Clinical Practice and the research ethics
      committees of member states.
FAU - Cairoli, Ester
AU  - Cairoli E
AD  - National Research Ethics Service, 4-8 Maple Street, London, UK.
      ester.cairoli@nres.npsa.nhs.uk
FAU - Davies, Hugh T
AU  - Davies HT
FAU - Helm, Jurgen
AU  - Helm J
FAU - Hook, Georg
AU  - Hook G
FAU - Knupfer, Petra
AU  - Knupfer P
FAU - Wells, Frank
AU  - Wells F
LA  - eng
PT  - Journal Article
DEP - 20110920
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Capital Financing
MH  - Education/organization & administration
MH  - Education, Continuing
MH  - Ethics Committees, Research/*standards
MH  - Ethics, Research/*education
MH  - Europe
MH  - Health Resources
MH  - Humans
MH  - Needs Assessment
EDAT- 2011/09/23 06:00
MHDA- 2012/05/25 06:00
CRDT- 2011/09/23 06:00
PHST- 2011/09/23 06:00 [entrez]
PHST- 2011/09/23 06:00 [pubmed]
PHST- 2012/05/25 06:00 [medline]
AID - medethics-2011-100064 [pii]
AID - 10.1136/medethics-2011-100064 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Mar;38(3):184-6. doi: 10.1136/medethics-2011-100064. Epub 2011
      Sep 20.


PMID- 21937176
OWN - NLM
STAT- MEDLINE
DCOM- 20120216
LR  - 20111024
IS  - 0398-7620 (Print)
IS  - 0398-7620 (Linking)
VI  - 59
IP  - 5
DP  - 2011 Oct
TI  - [Knowledge, attitudes and practices related to STD and HIV/AIDS: men having sex
      with men in Senegal].
PG  - 305-11
LID - 10.1016/j.respe.2011.03.060 [doi]
AB  - BACKGROUND: This study aimed to review knowledge, attitudes and practices related
      to sexual transmitted diseases (STD) and HIV/AIDS among men who have sex with men
      (MSM) in Senegal. METHOD: The study was undertaken from February 1st to June 30th
      2007, in three capitals cities in Senegal (one national, and two regional). It
      concerned the MSM that benefited from at least one of services of an MSM
      association. Studied variables included socio demographic characteristics, sexual
      practices, as well as knowledge and attitudes related to STDs and VIH/AIDS.
      Interviews took place during appointments obtained by direct phone call or by two
      MSM leaders intermediary. Data were seized and analyzed with Epi2000 Software.
      RESULTS: Among 245 registered MSM, 63 had a precise contact (address and/or phone
      number), and 49 aged in average of 25 years were investigated. Among them, one
      was illiterate, five studied Koran, seven Arab and 36 French. The
      socio-professional categories differentiated two officials, two merchants, one
      mechanic, one fighter, five artists, five restorers, seven tailors, 11 students, 
      and 15 unemployed. The associations, to which 35 HSH belonged, were related to
      sexuality (66%), religion (20%), social matters (8%) and economy (6%). Sexual
      habits, according to anal intercourse, differentiated the "Ubbi" or
      receptive/passive (57%), the "Yoos" or incertif/active (25%), the "Ubbi/Yoos" who
      play the two roles (14%) and the "neitherUbbi/norYoos" who had other practices
      than anal (4%). Practices between men, concerned mutual strokes (100%), fellatio 
      (61%) and anal intercourse (49%), counted 45% for remuneration, 35% of
      multi-unprotected partnership, and 12% of breaking condom. Practices with women
      were reported by 15 MSM (31%). Concerning STDs, at least one sign was reported by
      43 MSM, one transmission way by 42, one mean of protection by 47; and the first
      recourse was a health system for 36 MSM. The test of HIV/AIDS screening was done 
      by 38 HSH among which 30 withdrew the results. The "Ubby" adhered much more to
      associations, and practiced less unprotected vaginal intercourses and multi
      partnerships. CONCLUSION: Sexual relations between men, in Senegal, constitute a 
      factor of propagation for STDs and HIV/AIDS. Beliefs, values, and popular
      reactions still limit the big principles (liberty, equality, solidarity, and
      participation) of preventive and curative care. Therefore, ethics and
      effectiveness must be conciliated to face more MSM needs, for a better health of 
      the populations.
CI  - Copyright (c) 2011 Elsevier Masson SAS. All rights reserved.
FAU - Ndiaye, P
AU  - Ndiaye P
AD  - Service de medecine preventive et sante publique (MP/SP), faculte de medecine,
      pharmacie et odontologie (FMPO), universite Cheikh Anta DIOP (UCAD), Dakar Fann, 
      Senegal. pndiayempsp@yahoo.fr
FAU - Fall, A
AU  - Fall A
FAU - Tal-Dia, A
AU  - Tal-Dia A
FAU - Faye, A
AU  - Faye A
FAU - Diongue, M
AU  - Diongue M
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Connaissances, attitudes et pratiques relatives aux IST/VIH/sida: cas des hommes 
      ayant des rapports sexuels avec d'autres hommes au Senegal.
DEP - 20110919
PL  - France
TA  - Rev Epidemiol Sante Publique
JT  - Revue d'epidemiologie et de sante publique
JID - 7608039
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/epidemiology/*prevention &
      control/transmission
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - Gender Identity
MH  - HIV Infections/epidemiology/*prevention & control/transmission
MH  - *Health Knowledge, Attitudes, Practice
MH  - *Homosexuality, Male/psychology/statistics & numerical data
MH  - Humans
MH  - Male
MH  - Senegal/epidemiology
MH  - Sex Characteristics
MH  - Sexual Behavior/physiology/psychology/*statistics & numerical data
MH  - Sexually Transmitted Diseases/epidemiology/*prevention & control/transmission
MH  - Young Adult
EDAT- 2011/09/23 06:00
MHDA- 2012/02/18 06:00
CRDT- 2011/09/23 06:00
PHST- 2008/12/30 00:00 [received]
PHST- 2010/01/16 00:00 [revised]
PHST- 2011/03/29 00:00 [accepted]
PHST- 2011/09/23 06:00 [entrez]
PHST- 2011/09/23 06:00 [pubmed]
PHST- 2012/02/18 06:00 [medline]
AID - S0398-7620(11)00310-5 [pii]
AID - 10.1016/j.respe.2011.03.060 [doi]
PST - ppublish
SO  - Rev Epidemiol Sante Publique. 2011 Oct;59(5):305-11. doi:
      10.1016/j.respe.2011.03.060. Epub 2011 Sep 19.


PMID- 21936909
OWN - NLM
STAT- MEDLINE
DCOM- 20120301
LR  - 20220321
IS  - 1749-799X (Electronic)
IS  - 1749-799X (Linking)
VI  - 6
DP  - 2011 Sep 21
TI  - A genetic association study between growth differentiation factor 5 (GDF 5)
      polymorphism and knee osteoarthritis in Thai population.
PG  - 47
LID - 10.1186/1749-799X-6-47 [doi]
AB  - OBJECTIVE: Osteoarthritis (OA) is a multi-factorial disease and genetic factor is
      one of the important etiologic risk factors. Various genetic polymorphisms have
      been elucidated that they might be associated with OA. Recently, several studies 
      have shown an association between Growth Differentiation Factor 5(GDF5)
      polymorphism and knee OA. However, the role of genetic predisposing factor in
      each ethnic group cannot be replicated to all, with conflicting data in the
      literatures. Therefore, the aim of this study was to investigate the association 
      between GDF5 polymorphism and knee OA in Thai population. MATERIALS AND METHODS: 
      One hundred and ninety three patients aged 54-88 years who attended Ramathibodi
      Hospital were enrolled. Ninety cases with knee OA according to American College
      of Rheumatology criteria and one hundred and three cases in control group gave
      informed consent. Blood sample (5 ml) were collected for identification of GDF5
      (rs143383) single nucleotide polymorphism by PCR/RFLP according to a standard
      protocol. This study protocol was approved by the Ethics Committee on human
      experimentation of Ramathibodi Hospital Faculty of Medicine, Mahidol University. 
      Odds ratios (OR) and 95% confidence intervals were calculated for the risk of
      knee OA by genotype (TT, TC and CC) and allele (T/C) analyses. RESULTS: The
      baseline characteristics between two groups including job, smoking and activity
      were not different, except age and BMI. The entire cases and controls were in
      Hardy-Weinberg equilibrium (p > 0.05). The OA knee group (n = 90) had genotypic
      figure which has shown by TT 42.2% (n = 38), TC 45.6% (n = 41) and CC 12% (n =
      11), whereas the control group (n = 103) revealed TT 32% (n = 33), TC 45.6% (n = 
      47), and CC 22.3% (n = 23), respectively. Genotypic TT increased risk of knee OA 
      as compared to CC [OR = 2.41 (P = 0.04, 95%CI = 1.02-5.67)]. In the allele
      analysis, the T allele was found to be significantly associated with knee OA [OR 
      = 1.53 (P = 0.043, 95%CI = 1.01-2.30)]. CONCLUSION: These data suggested that
      GDF5 polymorphism has an association with knee OA in Thai ethnic. This finding
      also supports the hypothesis that OA has an important genetic component in its
      etiology, and GDF5 protein might play important role in the pathophysiology of
      the disease.
FAU - Tawonsawatruk, Tulyapruek
AU  - Tawonsawatruk T
AD  - Department of Orthopedics, Faculty of Medicine, Ramathibodi Hospital, Mahidol
      University, Bangkok 10400, Thailand. tulyapruek@gmail.com
FAU - Changthong, Theeraroj
AU  - Changthong T
FAU - Pingsuthiwong, Sarinee
AU  - Pingsuthiwong S
FAU - Trachoo, Objoon
AU  - Trachoo O
FAU - Sura, Thanyachai
AU  - Sura T
FAU - Wajanavisit, Wiwat
AU  - Wajanavisit W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110921
PL  - England
TA  - J Orthop Surg Res
JT  - Journal of orthopaedic surgery and research
JID - 101265112
RN  - 0 (GDF5 protein, human)
RN  - 0 (Growth Differentiation Factor 5)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Asians/ethnology/genetics
MH  - Case-Control Studies
MH  - Female
MH  - Genetic Predisposition to Disease/ethnology/genetics
MH  - Genotype
MH  - Growth Differentiation Factor 5/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Osteoarthritis, Knee/*ethnology/*genetics
MH  - Polymorphism, Genetic/*genetics
MH  - Thailand
PMC - PMC3189142
EDAT- 2011/09/23 06:00
MHDA- 2012/03/02 06:00
CRDT- 2011/09/23 06:00
PHST- 2011/03/27 00:00 [received]
PHST- 2011/09/21 00:00 [accepted]
PHST- 2011/09/23 06:00 [entrez]
PHST- 2011/09/23 06:00 [pubmed]
PHST- 2012/03/02 06:00 [medline]
AID - 1749-799X-6-47 [pii]
AID - 10.1186/1749-799X-6-47 [doi]
PST - epublish
SO  - J Orthop Surg Res. 2011 Sep 21;6:47. doi: 10.1186/1749-799X-6-47.


PMID- 21936879
OWN - NLM
STAT- MEDLINE
DCOM- 20120416
LR  - 20111118
IS  - 1365-2982 (Electronic)
IS  - 1350-1925 (Linking)
VI  - 23
IP  - 12
DP  - 2011 Dec
TI  - Postprandial proximal gastric acid pocket in patients after distal gastrectomy.
PG  - 1081-3
LID - 10.1111/j.1365-2982.2011.01790.x [doi]
AB  - BACKGROUND: An unbuffered postprandial proximal gastric acid pocket (PPGAP) has
      been noticed in the majority of normal individuals and patients with
      gastroesophageal reflux disease. The role of gastric anatomy, specifically the
      antrum, in the physiology of the PPGAP is not yet fully elucidated. This study
      aims to analyze the presence of PPGAP in patients submitted to distal
      gastrectomy. METHODS: A total of 15 patients who had a distal gastrectomy plus
      DII lymphadenectomy and Roux-en-Y reconstruction for gastric adenocarcinoma (mean
      age 64.3+/-8.4 years, 12 females) were studied. All patients were free of foregut
      symptoms after the operation. Patients underwent a high-resolution manometry. A
      station pull-through pH monitoring was performed from 5cm below the lower border 
      of the lower esophageal sphincter (LBLES) to the LBLES in increments of 1cm in a 
      fasting state and 10min after a standardized fatty meal. Postprandial proximal
      gastric acid pocket was defined by the presence of acid reading (pH<4) in a
      segment of the proximal stomach between non-acid segments distally (food) and
      proximally (LBLES). The PPGAP extent was recorded. The protocol was approved by
      local ethics committee. Key Results Acidity was not detected in the stomach of
      nine patients before meal. After meal, PPGAP was not found in three patients. In 
      three patients (20%), a PPGAP was noted with an extension of 1, 1 and 3cm.
      CONCLUSIONS & INFERENCES: In conclusion, PPGAP is present in a minority of
      patients after distal gastrectomy; this finding may suggest that the gastric
      antrum may play a role in the genesis of the PPGAP.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Herbella, F A M
AU  - Herbella FA
AD  - Department of Surgery, Escola Paulista de Medicina, Federal University of Sao
      Paulo, Sao Paulo, Brazil. herbella.dcir@epm.br
FAU - Vicentine, F P P
AU  - Vicentine FP
FAU - Silva, L C
AU  - Silva LC
FAU - Patti, M G
AU  - Patti MG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110921
PL  - England
TA  - Neurogastroenterol Motil
JT  - Neurogastroenterology and motility : the official journal of the European
      Gastrointestinal Motility Society
JID - 9432572
SB  - IM
MH  - Aged
MH  - Female
MH  - Gastrectomy/*adverse effects
MH  - Gastric Acid/*metabolism
MH  - Humans
MH  - Manometry/methods
MH  - Middle Aged
MH  - Postprandial Period/*physiology
MH  - Pyloric Antrum/*anatomy & histology/*surgery
MH  - Stomach Neoplasms/surgery
EDAT- 2011/09/23 06:00
MHDA- 2012/04/17 06:00
CRDT- 2011/09/23 06:00
PHST- 2011/09/23 06:00 [entrez]
PHST- 2011/09/23 06:00 [pubmed]
PHST- 2012/04/17 06:00 [medline]
AID - 10.1111/j.1365-2982.2011.01790.x [doi]
PST - ppublish
SO  - Neurogastroenterol Motil. 2011 Dec;23(12):1081-3. doi:
      10.1111/j.1365-2982.2011.01790.x. Epub 2011 Sep 21.


PMID- 21936605
OWN - NLM
STAT- MEDLINE
DCOM- 20120105
LR  - 20120413
IS  - 1445-6354 (Electronic)
IS  - 1445-6354 (Linking)
VI  - 11
IP  - 3
DP  - 2011
TI  - Managing environmental risks: the benefits of a place-based approach.
PG  - 1800
AB  - CONTEXT: Effective management of environmental risks such as food and water
      contamination requires both high quality scientific information and effective,
      informed social policy. Not only must health practitioners and policy-makers
      recognize the complexities of human health as a social phenomenon, they must also
      negotiate the vagaries of uncertainty, precaution, and ethics in their
      implementation of public health guidelines and advisories. For example, some
      health practitioners in Alaska have argued against implementation of US
      Environmental Protection Agency and World Health Organization's standardized
      consumption advisories for methylmercury (MeHg) in fish, in favor of place-based 
      approaches to evaluating and communicating risk. They stress the importance of
      traditional subsistence foods and lifestyles, along with other local
      environmental, economic, and cultural drivers and determinants of environmental
      health. Such place-based approaches have been successful in improving health
      outcomes in Alaska and elsewhere. ISSUE: Nevertheless, debate continues regarding
      the validity and ethics of place-based approaches to developing and communicating
      standards and advice for managing environmental risks. Recent critiques suggest
      that place-based approaches to environmental health represent an undesirable kind
      of regional 'exceptionalism': the implication of which is that precaution, in
      respect to acting on the best available objective science, is undermined by
      attention to subjective local values. In this article we comment on this debate, 
      a debate rooted in concerns regarding the delineation between science-based and
      policy-based decision-making. LESSONS LEARNED: Our experience with the social and
      ecological dimensions of MeHg contamination of fish and game in Alaska and
      elsewhere offers three considerations regarding the potential benefits available 
      through place-based approaches: (1) they can contribute to the accuracy and
      systematic characterization of risks and their relationship to multiple direct
      and indirect health outcomes; (2) they are more likely to inform actual changes
      in behavior; and (3) they afford greater transparency to the risk management
      process and therefore facilitate environmental justice. We stress that
      standardized risk assessments and advisories remain important for providing a
      precautionary baseline that can inform the management and enforcement of
      industrial and other polluting activities at the state level. However, the
      management of environmental health at the regional and local level requires an
      approach that is cognizant of local circumstances and needs, and addresses health
      in a systemic and integrative fashion capable of incorporating qualitative
      social, cultural, and economic drivers and determinants. Thus, we recommend a
      two-tiered approach that blends state-based and place-based environmental risk
      management.
FAU - Loring, Philip A
AU  - Loring PA
AD  - Alaska Center for Climate Assessment and Policy, University of Alaska Fairbanks, 
      Fairbanks, Alaska, USA. ploring@alaska.edu
FAU - Duffy, Lawrence K
AU  - Duffy LK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110919
PL  - Australia
TA  - Rural Remote Health
JT  - Rural and remote health
JID - 101174860
RN  - 0 (Methylmercury Compounds)
SB  - IM
MH  - Alaska
MH  - Animals
MH  - Decision Making/*ethics
MH  - Environmental Exposure/*prevention & control
MH  - Fishes/growth & development
MH  - Food Safety
MH  - Humans
MH  - Methylmercury Compounds/adverse effects
MH  - Policy Making
MH  - Public Health/legislation & jurisprudence
MH  - Regional Health Planning/legislation & jurisprudence
MH  - Risk Management/*ethics
MH  - United States
EDAT- 2011/09/23 06:00
MHDA- 2012/01/06 06:00
CRDT- 2011/09/23 06:00
PHST- 2011/09/23 06:00 [entrez]
PHST- 2011/09/23 06:00 [pubmed]
PHST- 2012/01/06 06:00 [medline]
AID - 1800 [pii]
PST - ppublish
SO  - Rural Remote Health. 2011;11(3):1800. Epub 2011 Sep 19.


PMID- 21936283
OWN - NLM
STAT- MEDLINE
DCOM- 20111021
LR  - 20110922
IS  - 0882-1577 (Print)
IS  - 0882-1577 (Linking)
VI  - 92
IP  - 5
DP  - 2011 Sep-Oct
TI  - Ramping up ethics' role: it is at the heart of health care mission.
PG  - 80-1
FAU - Hamel, Ron
AU  - Hamel R
AD  - Catholic Health Association, St. Louis, USA. rhamel@chausa.org
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Health Prog
JT  - Health progress (Saint Louis, Mo.)
JID - 8500263
MH  - Catholicism
MH  - Delivery of Health Care/*ethics
MH  - Hospitals, Religious
MH  - Humans
MH  - Organizational Objectives
MH  - Patient Protection and Affordable Care Act
MH  - United States
EDAT- 2011/09/23 06:00
MHDA- 2011/10/22 06:00
CRDT- 2011/09/23 06:00
PHST- 2011/09/23 06:00 [entrez]
PHST- 2011/09/23 06:00 [pubmed]
PHST- 2011/10/22 06:00 [medline]
PST - ppublish
SO  - Health Prog. 2011 Sep-Oct;92(5):80-1.


PMID- 21916720
OWN - NLM
STAT- MEDLINE
DCOM- 20120118
LR  - 20171116
IS  - 1087-0415 (Electronic)
IS  - 1081-0730 (Linking)
VI  - 16 Suppl 2
DP  - 2011 Aug
TI  - Communicating health through health footprints.
PG  - 158-74
LID - 10.1080/10810730.2011.596608 [doi]
AB  - The depth and scale of challenges posed by noncommunicable diseases such as
      diabetes mellitus and cardiovascular disease are now well known and clearly
      documented. Reducing the 4 key risk factors has been shown to reduce premature
      mortality and morbidity by 70% globally. The authors consider how affirmative
      action can be driven to reduce these risk factors through Health Footprints,
      targeted interventions within specific domains of consumption, on the basis of an
      assessment of the negative health effect of specific choices, with the goal of
      driving healthy choices and improving health. In this article, the authors
      propose a methodology that ties together insight from public health, behavioral
      economics, marketing, and health communication. They offer 3 specific examples
      for affirmative action: a Pigovian tax on unhealthy foods, group-level
      interventions on the basis of sharing key health data, and personalized
      prevention tailored to specific individuals. In addition, they discuss the
      approach to implementation, including the role of an apex coordinating
      organization in setting standards for data and ethics, and evaluation of the
      effect of interventions to drive continuous improvement.
FAU - Harrison, Oliver
AU  - Harrison O
AD  - Health Authority, Abu Dhabi, United Arab Emirates. oharrison@haad.ae
FAU - Hajat, Cother
AU  - Hajat C
FAU - Cooper, Cary
AU  - Cooper C
FAU - Averbuj, Gustavo
AU  - Averbuj G
FAU - Anderson, Peter
AU  - Anderson P
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Health Commun
JT  - Journal of health communication
JID - 9604100
MH  - Choice Behavior
MH  - Health Behavior
MH  - Health Communication/*methods
MH  - Health Promotion/*methods
MH  - Humans
MH  - Models, Psychological
MH  - Obesity/*prevention & control
MH  - Risk Factors
MH  - *Smoking Prevention
EDAT- 2011/09/23 06:00
MHDA- 2012/01/19 06:00
CRDT- 2011/09/16 06:00
PHST- 2011/09/16 06:00 [entrez]
PHST- 2011/09/23 06:00 [pubmed]
PHST- 2012/01/19 06:00 [medline]
AID - 10.1080/10810730.2011.596608 [doi]
PST - ppublish
SO  - J Health Commun. 2011 Aug;16 Suppl 2:158-74. doi: 10.1080/10810730.2011.596608.


PMID- 21934620
OWN - NLM
STAT- MEDLINE
DCOM- 20120104
LR  - 20110928
IS  - 1473-6578 (Electronic)
IS  - 0951-7367 (Linking)
VI  - 24
IP  - 6
DP  - 2011 Nov
TI  - Conceptual and ethical issues with brain-hardware interfaces.
PG  - 495-501
LID - 10.1097/YCO.0b013e32834bb8ca [doi]
AB  - PURPOSE OF REVIEW: Progress in neurosciences, increasing computational power, and
      ongoing miniaturization of micro-technological components enable both a better
      understanding of human brain functions and development of new diagnostic and
      therapeutic tools. Research and development as well as clinical application of
      devices designed for recording neural signals from the brain or stimulating brain
      areas respectively raise conceptual and ethical questions. RECENT FINDINGS:
      Ethical issues of stimulating devices are mainly discussed in the field of deep
      brain stimulation. The debate with respect to its use for Parkinson's disease
      focuses on patients' benefit and unintended consequences - sometimes framed as
      questions of identity and change of personality. As deep brain stimulation is
      currently tested for a broad variety of different diseases, including psychiatric
      disorders, minimal conscious state and Alzheimer's disease, recently increasing
      ethical attention is paid to issues of clinical research and clinical innovation.
      However, with respect to recording devices, specific implications for patients'
      autonomy and responsibility are at the core of the discussion. SUMMARY:
      Brain-hardware interfaces need continuing ethical discussion to realize their
      full beneficial potential and avoid the pitfalls of hasty application.
FAU - Clausen, Jens
AU  - Clausen J
AD  - Institute for Ethics and History of Medicine, University of Tubingen, Tubingen,
      Germany. jens.clausen@uni-tuebingen.de
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Curr Opin Psychiatry
JT  - Current opinion in psychiatry
JID - 8809880
SB  - IM
MH  - Biomedical Research/ethics/methods
MH  - Brain Mapping/*methods
MH  - Deep Brain Stimulation/ethics/*methods
MH  - Ethics, Medical
MH  - Humans
MH  - Personal Autonomy
MH  - *User-Computer Interface
EDAT- 2011/09/22 06:00
MHDA- 2012/01/05 06:00
CRDT- 2011/09/22 06:00
PHST- 2011/09/22 06:00 [entrez]
PHST- 2011/09/22 06:00 [pubmed]
PHST- 2012/01/05 06:00 [medline]
AID - 10.1097/YCO.0b013e32834bb8ca [doi]
PST - ppublish
SO  - Curr Opin Psychiatry. 2011 Nov;24(6):495-501. doi: 10.1097/YCO.0b013e32834bb8ca.


PMID- 21933810
OWN - NLM
STAT- MEDLINE
DCOM- 20120326
LR  - 20141120
IS  - 1465-735X (Electronic)
IS  - 0146-8693 (Linking)
VI  - 36
IP  - 10
DP  - 2011 Nov-Dec
TI  - Contemporary directions in research ethics in pediatric psychology: introduction 
      to the special section.
PG  - 1063-70
LID - 10.1093/jpepsy/jsr077 [doi]
FAU - Drotar, Dennis
AU  - Drotar D
LA  - eng
PT  - Introductory Journal Article
DEP - 20110920
PL  - United States
TA  - J Pediatr Psychol
JT  - Journal of pediatric psychology
JID - 7801773
SB  - IM
EIN - J Pediatr Psychol. 2012 Jan-Feb;37(1):119
MH  - Child
MH  - *Ethics, Research
MH  - Humans
MH  - Psychology, Child/*ethics
EDAT- 2011/09/22 06:00
MHDA- 2012/03/27 06:00
CRDT- 2011/09/22 06:00
PHST- 2011/09/22 06:00 [entrez]
PHST- 2011/09/22 06:00 [pubmed]
PHST- 2012/03/27 06:00 [medline]
AID - jsr077 [pii]
AID - 10.1093/jpepsy/jsr077 [doi]
PST - ppublish
SO  - J Pediatr Psychol. 2011 Nov-Dec;36(10):1063-70. doi: 10.1093/jpepsy/jsr077. Epub 
      2011 Sep 20.


PMID- 21933111
OWN - NLM
STAT- MEDLINE
DCOM- 20120822
LR  - 20220321
IS  - 2212-3873 (Electronic)
IS  - 1871-5303 (Linking)
VI  - 11
IP  - 4
DP  - 2011 Dec
TI  - Ovulation, implantation and placentation in females with obesity and metabolic
      disorders: life in the balance.
PG  - 285-301
AB  - Obesity due to endocrine and metabolic disorders causing dysfunctions of
      appetite-regulating pathways and energy balance is an increasingly concerning
      issue. Such form of obesity is mainly caused by the failure of elevated levels of
      the hormone leptin (LEP) to suppress feeding and mediate weight loss; the
      syndrome, caused by disruptions of signal transduction processes at the level of 
      leptin receptors (LEPR), has been named as leptin resistance. Alterations in
      genes coding for LEPR and other hypothalamic factors in obese individuals have
      been related to low rates of pregnancies and deliveries. Fertility depends mainly
      on the success of processes involving ovulation, fertilization, implantation,
      placentation and embryo development; processes that seem to be affected in obese 
      females. However, mechanistical research in human beings is very difficult to
      undertake, especially in reproductive issues, for both technical and ethical
      reasons. Thus, investigation is usually taken on animal models. Most of the
      studies have been carried out in mice, in which mutations in LEP and LEPR genes
      cause severe obese phenotypes (Leprob/ob and Leprdb/db mouse); in addition, such 
      genotypes are infertile. However, total loss of LEPR function by monogenic
      disorders in humans, unlike mice, are really scarce. Functional alterations by
      LEPR gene polymorphisms are more common; the same has been found in the swine, an
      animal model very close to human. This review outlines, from results of
      translational animal research and clinical studies, the factors, mechanisms and
      pathways involved in the reproductive failures of individuals with metabolic
      disorders during the critical period from ovulation to completion of placentation
      and early-embryo development.
FAU - Gonzalez-Bulnes, Antonio
AU  - Gonzalez-Bulnes A
AD  - Dpto. de Reproduccion Animal, INIA, Avda. Puerta de Hierro s/n. 28040-Madrid,
      Spain. bulnes@inia.es
FAU - Pallares, Pilar
AU  - Pallares P
FAU - Ovilo, Cristina
AU  - Ovilo C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Endocr Metab Immune Disord Drug Targets
JT  - Endocrine, metabolic & immune disorders drug targets
JID - 101269157
RN  - 0 (Leptin)
RN  - 0 (Receptors, Leptin)
SB  - IM
MH  - Animals
MH  - Embryo Implantation/*physiology
MH  - Female
MH  - Humans
MH  - Leptin/metabolism/physiology
MH  - Metabolic Diseases/complications/*metabolism/physiopathology
MH  - Obesity/complications/*metabolism/physiopathology
MH  - Ovulation/metabolism/*physiology
MH  - Placentation/*physiology
MH  - Pregnancy
MH  - Pregnancy Complications/metabolism/physiopathology
MH  - Receptors, Leptin/metabolism/physiology
EDAT- 2011/09/22 06:00
MHDA- 2012/08/23 06:00
CRDT- 2011/09/22 06:00
PHST- 2011/01/01 00:00 [received]
PHST- 2011/05/17 00:00 [accepted]
PHST- 2011/09/22 06:00 [entrez]
PHST- 2011/09/22 06:00 [pubmed]
PHST- 2012/08/23 06:00 [medline]
AID - EMID-DT-ABS-91 [pii]
AID - 10.2174/187153011797881193 [doi]
PST - ppublish
SO  - Endocr Metab Immune Disord Drug Targets. 2011 Dec;11(4):285-301. doi:
      10.2174/187153011797881193.


PMID- 21932740
OWN - NLM
STAT- MEDLINE
DCOM- 20111004
LR  - 20110921
IS  - 0002-7979 (Print)
IS  - 0002-7979 (Linking)
VI  - 78
IP  - 2
DP  - 2011 Summer
TI  - Swarm intelligence.
PG  - 34-43
AB  - The standard view of how things work is that an outside force impacts a group of 
      individuals and causes outcomes they are interested in. The outside force may not
      affect all individuals to the same extent, but we can summarize the effect by
      taking the average. Effective influence is thought to come from the top, not from
      the group that is being led. The alternative considered here is that a
      substantial degree of intelligence resided in the individuals or elements that
      someone wants to study or change. And these elements of the system interact with 
      each other. This phenomenon goes by many names, but will be called swarm
      intelligence here. There are many cases where simple rules followed at the local 
      level trump or outperform understanding or control from above. Five examples will
      be given: (a) ethics; (b) the progression of periodontal diseases; (b) dental
      continuing education; (c) leadership from within; and (d) the wisdom of group
      decision making.
FAU - Chambers, David W
AU  - Chambers DW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Coll Dent
JT  - The Journal of the American College of Dentists
JID - 7503057
SB  - IM
MH  - Decision Making
MH  - Diffusion of Innovation
MH  - Disease Progression
MH  - Ethics
MH  - *Group Processes
MH  - Humans
MH  - *Leadership
MH  - Periodontal Diseases/pathology
MH  - *Systems Theory
EDAT- 2011/09/22 06:00
MHDA- 2011/10/05 06:00
CRDT- 2011/09/22 06:00
PHST- 2011/09/22 06:00 [entrez]
PHST- 2011/09/22 06:00 [pubmed]
PHST- 2011/10/05 06:00 [medline]
PST - ppublish
SO  - J Am Coll Dent. 2011 Summer;78(2):34-43.


PMID- 21932739
OWN - NLM
STAT- MEDLINE
DCOM- 20111004
LR  - 20120123
IS  - 0002-7979 (Print)
IS  - 0002-7979 (Linking)
VI  - 78
IP  - 2
DP  - 2011 Summer
TI  - Writing off the copayment.
PG  - 26-33
AB  - Three dentists who have been involved in teaching ethics comment on a case where 
      an associate discovers that the 40% of collections she was expecting as
      compensation is being reduced because of the practice in the office of routinely 
      writing off patient copays. The commentators note legal requirements and
      professional codes, but generally seek alternatives that do not require that
      patients pay the amount agreed by insurance contracts.
FAU - Schwartz, Barry
AU  - Schwartz B
AD  - Schulich School of Medicine and Dentistry, Western Ontario University,
      bschwar@uwo.ca
FAU - Jenson, Larry E
AU  - Jenson LE
FAU - Roucka, Toni M
AU  - Roucka TM
FAU - Patthoff, Donald E
AU  - Patthoff DE
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Coll Dent
JT  - The Journal of the American College of Dentists
JID - 7503057
SB  - IM
CIN - J Am Coll Dent. 2011 Fall;78(3):4-5; author reply 5-6. PMID: 22263362
MH  - Codes of Ethics
MH  - Deception
MH  - Deductibles and Coinsurance/*ethics/legislation & jurisprudence
MH  - Dentist-Patient Relations/ethics
MH  - *Ethics, Dental
MH  - Fraud
MH  - Humans
MH  - Insurance, Dental/*ethics
MH  - Partnership Practice, Dental/ethics
EDAT- 2011/09/22 06:00
MHDA- 2011/10/05 06:00
CRDT- 2011/09/22 06:00
PHST- 2011/09/22 06:00 [entrez]
PHST- 2011/09/22 06:00 [pubmed]
PHST- 2011/10/05 06:00 [medline]
PST - ppublish
SO  - J Am Coll Dent. 2011 Summer;78(2):26-33.


PMID- 21932054
OWN - NLM
STAT- MEDLINE
DCOM- 20120710
LR  - 20220331
IS  - 1432-2161 (Electronic)
IS  - 0364-2348 (Linking)
VI  - 41
IP  - 5
DP  - 2012 May
TI  - The Hounsfield value for cortical bone geometry in the proximal humerus--an in
      vitro study.
PG  - 557-68
LID - 10.1007/s00256-011-1255-7 [doi]
AB  - INTRODUCTION: Fractures of the proximal humerus represent a major osteoporotic
      burden. Recent developments in CT imaging have emphasized the importance of
      cortical bone thickness distribution in the prevention and management of
      fragility fractures. We aimed to experimentally define the CT density of cortical
      bone in the proximal humerus for building cortical geometry maps. METHODS: With
      ethical approval, we used ten fresh-frozen human proximal humeri. These were
      stripped of all soft tissue and high-resolution CT images were then taken. The
      humeral heads were then subsequently resected to allow access to the metaphyseal 
      area. Using curettes, cancellous bone was removed down to hard cortical bone.
      Another set of CT images of the reamed specimen was then taken. Using CT imaging 
      software and a CAD interface, we then compared cortical contours at different CT 
      density thresholds to the reference inner cortical contour of our reamed
      specimens. Working with 3D model representations of these cortical maps, we were 
      able to accurately make distance comparison analyses based on different CT
      thresholds. RESULTS: We could compute a single closest value at 700 HU. No
      difference was found in the HU-based contours generated along the 500-900 HU
      pixels (p = 1.000). The contours were significantly different from those
      generated at 300, 400, 1,000, and 1,100 HU. CONCLUSIONS: A Hounsfield range of
      500-900 HU can accurately depict cortical bone geometry in the proximal humerus. 
      Thresholding outside this range leads to statistically significant inaccuracies. 
      Our results concur with a similar range reported in the literature for the
      proximal femur. Knowledge of regional variations in cortical bone thickness has
      direct implications for basic science studies on osteoporosis and its treatment, 
      but is also important for the orthopedic surgeon since our decision for treatment
      options is often guided by local bone quality.
FAU - Lim Fat, Daren
AU  - Lim Fat D
AD  - Investigations Carried Out at Anatomy Lab, Royal College of Surgeons in Ireland, 
      123 St. Stephen's Green, Dublin and Sports Surgery Clinic, Santry, Dublin,
      Ireland. darenlimfat@yahoo.com
FAU - Kennedy, Jim
AU  - Kennedy J
FAU - Galvin, Rose
AU  - Galvin R
FAU - O'Brien, Fergal
AU  - O'Brien F
FAU - Mc Grath, Frank
AU  - Mc Grath F
FAU - Mullett, Hannan
AU  - Mullett H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110920
PL  - Germany
TA  - Skeletal Radiol
JT  - Skeletal radiology
JID - 7701953
SB  - IM
MH  - Absorptiometry, Photon/methods
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Algorithms
MH  - Bone Density
MH  - Cadaver
MH  - Female
MH  - Femur/anatomy & histology/diagnostic imaging
MH  - Humans
MH  - Humerus/*anatomy & histology/*diagnostic imaging
MH  - *Imaging, Three-Dimensional
MH  - In Vitro Techniques
MH  - Middle Aged
MH  - Radiographic Image Enhancement/*methods
MH  - Software
MH  - Tomography, X-Ray Computed
MH  - User-Computer Interface
EDAT- 2011/09/21 06:00
MHDA- 2012/07/11 06:00
CRDT- 2011/09/21 06:00
PHST- 2011/03/15 00:00 [received]
PHST- 2011/08/08 00:00 [accepted]
PHST- 2011/05/23 00:00 [revised]
PHST- 2011/09/21 06:00 [entrez]
PHST- 2011/09/21 06:00 [pubmed]
PHST- 2012/07/11 06:00 [medline]
AID - 10.1007/s00256-011-1255-7 [doi]
PST - ppublish
SO  - Skeletal Radiol. 2012 May;41(5):557-68. doi: 10.1007/s00256-011-1255-7. Epub 2011
      Sep 20.


PMID- 21931634
OWN - NLM
STAT- MEDLINE
DCOM- 20120203
LR  - 20220409
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 6
IP  - 9
DP  - 2011
TI  - Type 2 diabetes is associated with altered NF-kappaB DNA binding activity, JNK
      phosphorylation, and AMPK phosphorylation in skeletal muscle after LPS.
PG  - e23999
LID - 10.1371/journal.pone.0023999 [doi]
AB  - UNLABELLED: Systemic inflammation is often associated with impaired glucose
      metabolism. We therefore studied the activation of inflammatory pathway
      intermediates that interfere with glucose uptake during systemic inflammation by 
      applying a standardised inflammatory stimulus in vivo. After ethical approval,
      informed consent and a thorough physical examination, 10 patients with type 2
      diabetes and 10 participants with normal glucose tolerance (NGT) were given an
      intravenous bolus of E. coli lipopolysaccharide (LPS) of 0.3 ng/kg. Skeletal
      muscle biopsies and plasma were obtained at baseline and two, four and six hours 
      after LPS. Nuclear factor (NF)-kappaB p65 DNA binding activity measured by ELISA,
      tumor necrosis factor-alpha and interleukin-6 mRNA expression analysed by real
      time reverse transcription polymerase chain reaction, and abundance of inhibitor 
      of NF-kappaB (IkappaB)alpha, phosphorylated c-Jun-N-terminal kinase (JNK),
      AMP-activated protein kinase (AMPK), and acetyl-CoA carboxylase measured by
      Western blotting were detected in muscle biopsy samples. Relative to subjects
      with NGT, patients with type 2 diabetes exhibited a more pronounced increase in
      NF-kappaB binding activity and JNK phosphorylation after LPS, whereas skeletal
      muscle cytokine mRNA expression did not differ significantly between groups. AMPK
      phosphorylation increased in volunteers with NGT, but not in those with diabetes.
      The present findings indicate that pathways regulating glucose uptake in skeletal
      muscle may be involved in the development of inflammation-associated
      hyperglycemia. Patients with type 2 diabetes exhibit changes in these pathways,
      which may ultimately render such patients more prone to develop dysregulated
      glucose disposal in the context of systemic inflammation. TRIAL REGISTRATION:
      ClinicalTrials.gov NCT00412906.
FAU - Andreasen, Anne Sofie
AU  - Andreasen AS
AD  - Centre of Inflammation and Metabolism, Department of Infectious Diseases and
      CMRC, University Hospital Rigshospitalet, Copenhagen, Denmark.
      sofie_andreasen@msn.com
FAU - Kelly, Meghan
AU  - Kelly M
FAU - Berg, Ronan Martin Griffin
AU  - Berg RM
FAU - Moller, Kirsten
AU  - Moller K
FAU - Pedersen, Bente Klarlund
AU  - Pedersen BK
LA  - eng
SI  - ClinicalTrials.gov/NCT00412906
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110913
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Lipopolysaccharides)
RN  - 0 (RNA, Messenger)
RN  - 0 (Transcription Factor RelA)
RN  - 9007-49-2 (DNA)
RN  - EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.31 (AMP-Activated Protein Kinases)
RN  - EC 6.4.1.2 (Acetyl-CoA Carboxylase)
SB  - IM
MH  - AMP-Activated Protein Kinases/*metabolism
MH  - Acetyl-CoA Carboxylase/metabolism
MH  - Adult
MH  - Aged
MH  - DNA/*metabolism
MH  - Diabetes Mellitus, Type 2/genetics/*metabolism/pathology/physiopathology
MH  - Gene Expression Regulation/drug effects
MH  - Humans
MH  - Insulin Resistance
MH  - JNK Mitogen-Activated Protein Kinases/*metabolism
MH  - Lipopolysaccharides/*pharmacology
MH  - Male
MH  - Middle Aged
MH  - Muscle, Skeletal/*drug effects/enzymology/metabolism/pathology
MH  - Phosphorylation/drug effects
MH  - Protein Binding/drug effects
MH  - RNA, Messenger/genetics/metabolism
MH  - Transcription Factor RelA/genetics/*metabolism
PMC - PMC3172218
EDAT- 2011/09/21 06:00
MHDA- 2012/02/04 06:00
CRDT- 2011/09/21 06:00
PHST- 2011/02/10 00:00 [received]
PHST- 2011/07/27 00:00 [accepted]
PHST- 2011/09/21 06:00 [entrez]
PHST- 2011/09/21 06:00 [pubmed]
PHST- 2012/02/04 06:00 [medline]
AID - 10.1371/journal.pone.0023999 [doi]
AID - PONE-D-11-03335 [pii]
PST - ppublish
SO  - PLoS One. 2011;6(9):e23999. doi: 10.1371/journal.pone.0023999. Epub 2011 Sep 13.


PMID- 21931600
OWN - NLM
STAT- MEDLINE
DCOM- 20120203
LR  - 20220330
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 6
IP  - 9
DP  - 2011
TI  - A systematic review of research on the meaning, ethics and practices of
      authorship across scholarly disciplines.
PG  - e23477
LID - 10.1371/journal.pone.0023477 [doi]
AB  - BACKGROUND: The purpose of this systematic review was to evaluate evidence about 
      authorship issues and provide synthesis of research on authorship across all
      research fields. METHODS: We searched bibliographical databases to identify
      articles describing empirical quantitive or qualitative research from all
      scholarly fields on different aspects of authorship. Search was limited to
      original articles and reviews. RESULTS: The final sample consisted of 123
      articles reporting results from 118 studies. Most studies came for biomedical and
      health research fields and social sciences. Study design was usually a survey
      (53%) or descriptive study (27%); only 2 studies used randomized design. We
      identified four 4 general themes common to all research disciplines: authorship
      perceptions, definitions and practices, defining order of authors on the byline, 
      ethical and unethical authorship practices, and authorship issues related to
      student/non-research personnel-supervisor collaboration. For 14 survey studies, a
      meta-analysis showed a pooled weighted average of 29% (95% CI 24% to 35%)
      researchers reporting their own or others' experience with misuse of authorship. 
      Authorship misuse was reported more often by researcher outside of the USA and
      UK: 55% (95% CI 45% to 64%) for 4 studies in France, South Africa, India and
      Bangladesh vs. 23% (95% CI 18% to 28%) in USA/UK or international journal
      settings. INTERPRETATION: High prevalence of authorship problems may have severe 
      impact on the integrity of the research process, just as more serious forms of
      research misconduct. There is a need for more methodologically rigorous studies
      to understand the allocation of publication credit across research disciplines.
FAU - Marusic, Ana
AU  - Marusic A
AD  - Department of Research in Biomedicine and Health, University of Split School of
      Medicine, Split, Croatia. ana.marusic@mefst.hr
FAU - Bosnjak, Lana
AU  - Bosnjak L
FAU - Jeroncic, Ana
AU  - Jeroncic A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20110908
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - *Authorship
MH  - Cooperative Behavior
MH  - *Ethics, Research
MH  - Scientific Misconduct
MH  - *Terminology as Topic
PMC - PMC3169533
EDAT- 2011/09/21 06:00
MHDA- 2012/02/04 06:00
CRDT- 2011/09/21 06:00
PHST- 2011/06/29 00:00 [received]
PHST- 2011/07/19 00:00 [accepted]
PHST- 2011/09/21 06:00 [entrez]
PHST- 2011/09/21 06:00 [pubmed]
PHST- 2012/02/04 06:00 [medline]
AID - 10.1371/journal.pone.0023477 [doi]
AID - PONE-D-11-11869 [pii]
PST - ppublish
SO  - PLoS One. 2011;6(9):e23477. doi: 10.1371/journal.pone.0023477. Epub 2011 Sep 8.


PMID- 21931577
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1748-2631 (Electronic)
IS  - 1748-2623 (Linking)
VI  - 6
IP  - 3
DP  - 2011
TI  - Corroborating indicates nurses' ethical values in a geriatric ward.
LID - 10.3402/qhw.v6i3.7291 [doi]
AB  - The aim of the study was to identify nurses' ethical values, which become
      apparent through their behaviour in the interactions with older patients in
      caring encounters at a geriatric clinic.Descriptions of ethics in a caring
      practice are a problem since they are vague compared with the four principles of 
      autonomy, beneficence, non-maleficence, and justice.A Grounded Theory methodology
      was used. In total, 65 observations and follow-up interviews with 20 nurses were 
      conducted, and data were analysed by constant comparative analysis.THREE
      CATEGORIES WERE IDENTIFIED: showing consideration, connecting, and caring for.
      These categories formed the basis of the core category: "Corroborating." In
      corroborating, the focus is on the person in need of integrity and
      self-determination; that is, the autonomy principle. A similar concept was
      earlier described in regard to confirming. Corroborating deals more with support 
      and interaction. It is not enough to be kind and show consideration (i.e., to
      benefit someone); nurses must also connect and care for the older person (i.e.,
      demonstrate non-maleficence) in order to corroborate that person.The findings of 
      this study can improve the ethics of nursing care. There is a need for research
      on development of a high standard of nursing care to corroborate the older
      patients in order to maintain their autonomy, beneficence, and non-maleficence.
      The principal of justice was not specifically identified as a visible nursing
      action. However, all older patients received treatment, care, and reception in an
      equivalent manner.
FAU - Jonasson, Lise-Lotte
AU  - Jonasson LL
AD  - Department of Nursing Science, School of Health Sciences, University of
      Jonkoping, Sweden.
FAU - Liss, Per-Erik
AU  - Liss PE
FAU - Westerlind, Bjorn
AU  - Westerlind B
FAU - Bertero, Carina
AU  - Bertero C
LA  - eng
PT  - Journal Article
DEP - 20110914
PL  - United States
TA  - Int J Qual Stud Health Well-being
JT  - International journal of qualitative studies on health and well-being
JID - 101256506
PMC - PMC3174776
OTO - NOTNLM
OT  - Ethical values
OT  - geriatric wards
OT  - grounded theory
OT  - nurses' behaviour
OT  - nursing ethics
EDAT- 2011/09/21 06:00
MHDA- 2011/09/21 06:01
CRDT- 2011/09/21 06:00
PHST- 2011/08/08 00:00 [accepted]
PHST- 2011/09/21 06:00 [entrez]
PHST- 2011/09/21 06:00 [pubmed]
PHST- 2011/09/21 06:01 [medline]
AID - 10.3402/qhw.v6i3.7291 [doi]
AID - QHW-6-7291 [pii]
PST - ppublish
SO  - Int J Qual Stud Health Well-being. 2011;6(3). pii: QHW-6-7291. doi:
      10.3402/qhw.v6i3.7291. Epub 2011 Sep 14.


PMID- 21931455
OWN - NLM
STAT- MEDLINE
DCOM- 20120327
LR  - 20211020
IS  - 1553-6467 (Electronic)
IS  - 0002-9459 (Linking)
VI  - 75
IP  - 6
DP  - 2011 Aug 10
TI  - Lethal injection as a component of a therapeutics toxicology module.
PG  - 117
LID - 10.5688/ajpe756117 [doi]
AB  - OBJECTIVE: To create and implement a required module that addresses both the
      clinical and ethical issues surrounding the use of lethal injection as a means of
      capital punishment. DESIGN: As a component of a pharmacotherapeutics module in
      toxicology, pharmacy students were introduced to ethical and clinical
      considerations and controversies with the use of drugs as a means of capital
      punishment. Basic information was provided on the history of capital punishment
      and the origins of lethal injection. Pharmacotherapeutic limitations and
      challenges were presented in the context of clinical and ethical dilemmas.
      ASSESSMENT: Instructed material was assessed using block course examinations that
      had both objective and subjective components. Students were asked to synthesize
      information by both purposing a lethal injection reversal protocol and by acting 
      as consults in the fictional design of more effective lethal injection protocols.
      Students provided formative and summative evaluations of the instruction through 
      regular student liaison meetings and summative course evaluations. CONCLUSION:
      Lethal injection as a means of capital punishment in the United States is a
      controversial and ethically challenging topic on which pharmacists may be
      consulted and therefore should be knowledgeable about. Students positively
      evaluated this lethal injection module, which covered multiple clinical and
      ethical issues.
FAU - Romanelli, Frank
AU  - Romanelli F
AD  - University of Kentucky College of Pharmacy, Lexington, 40536, USA. froma2@uky.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Pharm Educ
JT  - American journal of pharmaceutical education
JID - 0372650
SB  - IM
MH  - *Capital Punishment
MH  - *Curriculum
MH  - Drug Therapy/methods
MH  - Education, Pharmacy/*methods
MH  - Educational Measurement/methods
MH  - Humans
MH  - Pharmacists
MH  - *Students, Pharmacy
MH  - Toxicology/*education
MH  - United States
PMC - PMC3175686
EDAT- 2011/09/21 06:00
MHDA- 2012/03/28 06:00
CRDT- 2011/09/21 06:00
PHST- 2010/12/03 00:00 [received]
PHST- 2011/12/26 00:00 [accepted]
PHST- 2011/09/21 06:00 [entrez]
PHST- 2011/09/21 06:00 [pubmed]
PHST- 2012/03/28 06:00 [medline]
AID - 10.5688/ajpe756117 [doi]
AID - ajpe117 [pii]
PST - ppublish
SO  - Am J Pharm Educ. 2011 Aug 10;75(6):117. doi: 10.5688/ajpe756117.


PMID- 21931335
OWN - NLM
STAT- MEDLINE
DCOM- 20111109
LR  - 20211020
IS  - 1471-0048 (Electronic)
IS  - 1471-003X (Linking)
VI  - 12
IP  - 10
DP  - 2011 Sep 20
TI  - In search of biomarkers for autism: scientific, social and ethical challenges.
PG  - 603-12
LID - 10.1038/nrn3113 [doi]
AB  - There is widespread hope that the discovery of valid biomarkers for autism will
      both reveal the causes of autism and enable earlier and more targeted methods for
      diagnosis and intervention. However, growing enthusiasm about recent advances in 
      this area of autism research needs to be tempered by an awareness of the major
      scientific challenges and the important social and ethical concerns arising from 
      the development of biomarkers and their clinical application. Collaborative
      approaches involving scientists and other stakeholders must combine the search
      for valid, clinically useful autism biomarkers with efforts to ensure that
      individuals with autism and their families are treated with respect and
      understanding.
FAU - Walsh, Pat
AU  - Walsh P
AD  - Centre of Medical Law and Ethics, School of Law, King's College, London WC2R 2LS,
      UK. patricia.walsh@kcl.ac.uk
FAU - Elsabbagh, Mayada
AU  - Elsabbagh M
FAU - Bolton, Patrick
AU  - Bolton P
FAU - Singh, Ilina
AU  - Singh I
LA  - eng
GR  - G0500870/MRC_/Medical Research Council/United Kingdom
GR  - G0701484/MRC_/Medical Research Council/United Kingdom
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110920
PL  - England
TA  - Nat Rev Neurosci
JT  - Nature reviews. Neuroscience
JID - 100962781
RN  - 0 (Biomarkers)
SB  - IM
CIN - Nat Rev Neurosci. 2011 Dec;12(12):769; author reply 769. PMID: 22095067
MH  - Autistic Disorder/*diagnosis/etiology
MH  - *Biomarkers
MH  - Humans
MH  - Predictive Value of Tests
EDAT- 2011/09/21 06:00
MHDA- 2011/11/10 06:00
CRDT- 2011/09/21 06:00
PHST- 2011/09/21 06:00 [entrez]
PHST- 2011/09/21 06:00 [pubmed]
PHST- 2011/11/10 06:00 [medline]
AID - nrn3113 [pii]
AID - 10.1038/nrn3113 [doi]
PST - epublish
SO  - Nat Rev Neurosci. 2011 Sep 20;12(10):603-12. doi: 10.1038/nrn3113.


PMID- 21931318
OWN - NLM
STAT- MEDLINE
DCOM- 20121107
LR  - 20211203
IS  - 1476-5578 (Electronic)
IS  - 1359-4184 (Linking)
VI  - 17
IP  - 6
DP  - 2012 Jun
TI  - Deep brain stimulation in addiction: a review of potential brain targets.
PG  - 572-83
LID - 10.1038/mp.2011.114 [doi]
AB  - Deep brain stimulation (DBS) is an adjustable, reversible, non-destructive
      neurosurgical intervention using implanted electrodes to deliver electrical
      pulses to areas in the brain. DBS is currently investigated in psychiatry for the
      treatment of refractory obsessive-compulsive disorder, Tourette syndrome and
      depressive disorder. Although recent research in both animals and humans has
      indicated that DBS may be an effective intervention for patients with
      treatment-refractory addiction, it is not yet entirely clear which brain areas
      should be targeted. The objective of this review is to provide a systematic
      overview of the published literature on DBS and addiction and outline the most
      promising target areas using efficacy and adverse event data from both
      preclinical and clinical studies. We found 7 animal studies targeting six
      different brain areas: nucleus accumbens (NAc), subthalamic nucleus (STN), dorsal
      striatum, lateral habenula, medial prefrontal cortex (mPFC) and hypothalamus, and
      11 human studies targeting two different target areas: NAc and STN. Our analysis 
      of the literature suggests that the NAc is currently the most promising DBS
      target area for patients with treatment-refractory addiction. The mPFC is another
      promising target, but needs further exploration to establish its suitability for 
      clinical purposes. We conclude the review with a discussion on translational
      issues in DBS research, medical ethical considerations and recommendations for
      clinical trials with DBS in patients with addiction.
FAU - Luigjes, J
AU  - Luigjes J
AD  - Department of Psychiatry, Academic Medical Center, University of Amsterdam,
      Amsterdam, The Netherlands. judyluigjes@gmail.com
FAU - van den Brink, W
AU  - van den Brink W
FAU - Feenstra, M
AU  - Feenstra M
FAU - van den Munckhof, P
AU  - van den Munckhof P
FAU - Schuurman, P R
AU  - Schuurman PR
FAU - Schippers, R
AU  - Schippers R
FAU - Mazaheri, A
AU  - Mazaheri A
FAU - De Vries, T J
AU  - De Vries TJ
FAU - Denys, D
AU  - Denys D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110920
PL  - England
TA  - Mol Psychiatry
JT  - Molecular psychiatry
JID - 9607835
SB  - IM
MH  - Animals
MH  - Brain/*physiology
MH  - Deep Brain Stimulation/adverse effects/ethics/methods/*psychology
MH  - Humans
MH  - Substance-Related Disorders/*therapy
MH  - Translational Research, Biomedical/methods
MH  - Treatment Failure
EDAT- 2011/09/21 06:00
MHDA- 2012/11/08 06:00
CRDT- 2011/09/21 06:00
PHST- 2011/09/21 06:00 [entrez]
PHST- 2011/09/21 06:00 [pubmed]
PHST- 2012/11/08 06:00 [medline]
AID - mp2011114 [pii]
AID - 10.1038/mp.2011.114 [doi]
PST - ppublish
SO  - Mol Psychiatry. 2012 Jun;17(6):572-83. doi: 10.1038/mp.2011.114. Epub 2011 Sep
      20.


PMID- 21931242
OWN - NLM
STAT- MEDLINE
DCOM- 20120222
LR  - 20110920
IS  - 1556-2654 (Electronic)
IS  - 1556-2646 (Linking)
VI  - 6
IP  - 3
DP  - 2011 Sep
TI  - How often are ethics approval and informed consent reported in publications on
      health research in Cameroon? A five-year review.
PG  - 93-7
LID - 10.1525/jer.2011.6.3.93 [doi]
AB  - We assessed the extent of research ethics approval and informed consent reporting
      in publications emanating from Cameroon and indexed in PubMed from 2005-2009. In 
      our review of 219 full-length articles, we found that 57.53% reported ethics
      approval, 70.78% informed consent, and 50.68% both ethics approval and informed
      consent. Reporting these procedures was more common in randomized clinical trials
      than in other study designs. Also, 59.52% of the articles on vulnerable
      populations documented ethics approval and 76.19% documented informed consent.
      This study also identified some structures for ethics review and recommends some 
      next steps for research on the quality of ethics review in Cameroon.
FAU - Munung, Nchangwi Syntia
AU  - Munung NS
AD  - Department of Biochemistry and Microbiology, University of Buea, Cameroon.
      nchangwisyntia@yahoo.com
FAU - Che, Chi Primus
AU  - Che CP
FAU - Ouwe-Missi-Oukem-Boyer, Odile
AU  - Ouwe-Missi-Oukem-Boyer O
FAU - Tangwa, Godfrey B
AU  - Tangwa GB
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Cameroon
MH  - Clinical Trials as Topic/*ethics/statistics & numerical data
MH  - Documentation/*ethics/statistics & numerical data
MH  - *Editorial Policies
MH  - Ethics Committees, Research
MH  - *Ethics, Research
MH  - Humans
MH  - Informed Consent/*statistics & numerical data
MH  - Periodicals as Topic/*ethics/standards/statistics & numerical data
MH  - Vulnerable Populations/*statistics & numerical data
EDAT- 2011/09/21 06:00
MHDA- 2012/02/23 06:00
CRDT- 2011/09/21 06:00
PHST- 2011/09/21 06:00 [entrez]
PHST- 2011/09/21 06:00 [pubmed]
PHST- 2012/02/23 06:00 [medline]
AID - 10.1525/jer.2011.6.3.93 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2011 Sep;6(3):93-7. doi: 10.1525/jer.2011.6.3.93.


PMID- 21931241
OWN - NLM
STAT- MEDLINE
DCOM- 20120222
LR  - 20211020
IS  - 1556-2654 (Electronic)
IS  - 1556-2646 (Linking)
VI  - 6
IP  - 3
DP  - 2011 Sep
TI  - HIV/AIDS research conducted in the developing world and sponsored by the
      developed world: reporting of research ethics committee review in two countries.
PG  - 83-91
LID - 10.1525/jer.2011.6.3.83 [doi]
AB  - We explored how often journal articles reporting HIV research sponsored by a
      developed country, but conducted in a developing country, mention research ethics
      committee (REC) approval from both countries, and what factors are involved. Of
      all such 2007 articles on Medline conducted in one of four developing countries
      (N = 154), only 52% mentioned such dual approval. Mention of dual vs. single
      approval was more likely among articles with >/= 50% sponsor country authors, and
      the United States as the sponsor country. Also, dual approval was more likely
      among articles that mentioned informed consent and funding, had >/= 50% sponsor
      country authors, were biomedical (vs. psychosocial), and appeared in journals
      adopting International Committee Medical Journal Editors (ICMJE) guidelines. Dual
      approval was thus obtained in only half of the articles and was associated with
      ethical and logistic issues, indicating the need for clearer and more universally
      accepted guidelines.
FAU - Chin, Lisa Judy
AU  - Chin LJ
AD  - Columbia University College of Physicians & Surgeons & Mailman School of Public
      Health, 1051 Riverside Drive, New York, NY 10032, USA.
FAU - Rifai-Bashjawish, Hoda
AU  - Rifai-Bashjawish H
FAU - Kleinert, Kelly
AU  - Kleinert K
FAU - Saltman, Alexandra
AU  - Saltman A
FAU - Leu, Cheng-Shiun
AU  - Leu CS
FAU - Klitzman, Robert
AU  - Klitzman R
LA  - eng
GR  - 5R01HG04214/HG/NHGRI NIH HHS/United States
GR  - P30 MH043520/MH/NIMH NIH HHS/United States
GR  - T35 HL007616/HL/NHLBI NIH HHS/United States
GR  - R01 HG004214/HG/NHGRI NIH HHS/United States
GR  - R01 HG004214-01/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Acquired Immunodeficiency Syndrome
MH  - Authorship
MH  - Bibliometrics
MH  - Biomedical Research/*ethics
MH  - Developed Countries
MH  - Developing Countries
MH  - *Editorial Policies
MH  - *Ethics Committees, Research
MH  - *Ethics, Research
MH  - Guidelines as Topic
MH  - HIV
MH  - *HIV Infections
MH  - Humans
MH  - Informed Consent/ethics
MH  - *International Cooperation
MH  - Periodicals as Topic/*ethics/statistics & numerical data
MH  - Publishing/*ethics/statistics & numerical data
MH  - United States
PMC - PMC3459235
MID - NIHMS369356
EDAT- 2011/09/21 06:00
MHDA- 2012/02/23 06:00
CRDT- 2011/09/21 06:00
PHST- 2011/09/21 06:00 [entrez]
PHST- 2011/09/21 06:00 [pubmed]
PHST- 2012/02/23 06:00 [medline]
AID - 10.1525/jer.2011.6.3.83 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2011 Sep;6(3):83-91. doi: 10.1525/jer.2011.6.3.83.


PMID- 21931240
OWN - NLM
STAT- MEDLINE
DCOM- 20120222
LR  - 20110920
IS  - 1556-2654 (Electronic)
IS  - 1556-2646 (Linking)
VI  - 6
IP  - 3
DP  - 2011 Sep
TI  - Ancillary care in public health intervention research in low-resource settings:
      researchers' practices and decision-making.
PG  - 73-81
LID - 10.1525/jer.2011.6.3.73 [doi]
AB  - Little is known about researchers' practices regarding the provision of ancillary
      care (AC) in public health intervention studies they have conducted and the
      factors that influence their decisions about whether to provide ancillary care in
      low-resource settings. We conducted 52 in-person in-depth interviews with public 
      health researchers. Data analysis was iterative and led to the identification of 
      themes and patterns among themes. We found that researchers who conduct their
      research in the community setting are more likely to identify and plan for the AC
      needs of potential research subjects before a study begins, whereas those
      affiliated with a permanent facility are more likely to deliver AC to research
      subjects on an ad hoc basis. Our findings suggest that on the whole, at least for
      public health intervention research in low-resource settings, researchers
      conducting research in the community setting confront more complex ethical and
      operational challenges in their decision-making about AC than do researchers
      conducting facility-based studies.
FAU - Taylor, Holly A
AU  - Taylor HA
AD  - Department of Health Policy and Management, Johns Hopkins Bloomberg School of
      Public Health, 1809 Ashland Avenue, Baltimore, MD 21205, USA. htaylor@jhsph.edu
FAU - Merritt, Maria W
AU  - Merritt MW
FAU - Mullany, Luke C
AU  - Mullany LC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Ancillary Services, Hospital/*ethics
MH  - Asia, Western
MH  - *Decision Making
MH  - Ethics, Research
MH  - Female
MH  - Health Planning
MH  - Health Resources
MH  - Health Services Research/*ethics
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - *Poverty
MH  - Public Health/*ethics
MH  - Research Personnel
MH  - Residence Characteristics
EDAT- 2011/09/21 06:00
MHDA- 2012/02/23 06:00
CRDT- 2011/09/21 06:00
PHST- 2011/09/21 06:00 [entrez]
PHST- 2011/09/21 06:00 [pubmed]
PHST- 2012/02/23 06:00 [medline]
AID - 10.1525/jer.2011.6.3.73 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2011 Sep;6(3):73-81. doi: 10.1525/jer.2011.6.3.73.


PMID- 21931239
OWN - NLM
STAT- MEDLINE
DCOM- 20120222
LR  - 20211020
IS  - 1556-2654 (Electronic)
IS  - 1556-2646 (Linking)
VI  - 6
IP  - 3
DP  - 2011 Sep
TI  - Screening for understanding of research in the inpatient psychiatry setting.
PG  - 65-72
LID - 10.1525/jer.2011.6.3.65 [doi]
AB  - People with mental illness constitute a substantial proportion of smokers and an 
      important population for smoking cessation research. Obtaining informed consent
      in this population is a critical ethical endeavor. We examined performance on a
      three-item instrument (3Q) designed to screen for understanding of several key
      elements of research: study purpose, risks, and benefits. Patients were
      clinically diagnosed with primary unipolar depression (n = 40), a primary
      psychotic disorder (n = 32), both mood and psychotic disorders (n = 17), and
      primary bipolar disorder (n = 14). Among an ethnically diverse sample of 124
      psychiatric inpatients approached for a smoking cessation trial, 107 (86%)
      performed adequately on the 3Q (i.e., obtained a score of at least 3 out of a
      possible 6). Patients were better able to identify the study risks and benefits
      than to describe the study purpose. The 3Q appears to be a useful tool for
      researchers working with vulnerable psychiatric patients.
FAU - Hickman, Norval J
AU  - Hickman NJ
AD  - Treatment Research Center in the Department of Psychiatry, University of
      California-San Francisco, 401 Parnassus Avenue, San Francisco, CA 94143, USA.
      Norval.Hickman@ucsf.edu
FAU - Prochaska, Judith J
AU  - Prochaska JJ
FAU - Dunn, Laura B
AU  - Dunn LB
LA  - eng
GR  - T32 DA007250-16A2/DA/NIDA NIH HHS/United States
GR  - R01 AG027986/AG/NIA NIH HHS/United States
GR  - T32DA007250/DA/NIDA NIH HHS/United States
GR  - P50 DA009253/DA/NIDA NIH HHS/United States
GR  - K23DA018691/DA/NIDA NIH HHS/United States
GR  - R01AG027986/AG/NIA NIH HHS/United States
GR  - P50DA09253/DA/NIDA NIH HHS/United States
GR  - T32 DA007250/DA/NIDA NIH HHS/United States
GR  - K23 DA018691/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Adult
MH  - Clinical Trials as Topic/*ethics
MH  - *Comprehension
MH  - *Ethics, Research
MH  - Female
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Inpatients
MH  - Male
MH  - *Mental Disorders
MH  - Middle Aged
MH  - Patient Satisfaction
MH  - Risk
MH  - Smoking
MH  - *Smoking Cessation
MH  - Surveys and Questionnaires
MH  - Vulnerable Populations
PMC - PMC3357117
MID - NIHMS369349
EDAT- 2011/09/21 06:00
MHDA- 2012/02/23 06:00
CRDT- 2011/09/21 06:00
PHST- 2011/09/21 06:00 [entrez]
PHST- 2011/09/21 06:00 [pubmed]
PHST- 2012/02/23 06:00 [medline]
AID - 10.1525/jer.2011.6.3.65 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2011 Sep;6(3):65-72. doi: 10.1525/jer.2011.6.3.65.


PMID- 21931238
OWN - NLM
STAT- MEDLINE
DCOM- 20120222
LR  - 20191210
IS  - 1556-2654 (Electronic)
IS  - 1556-2646 (Linking)
VI  - 6
IP  - 3
DP  - 2011 Sep
TI  - Ethical issues in research on sensitive topics: participants' experiences of
      distress and benefit.
PG  - 55-64
LID - 10.1525/jer.2011.6.3.55 [doi]
AB  - While many studies ask participants to disclose sensitive information or to
      participate in emotionally arousing tasks, little is known about participants'
      subjective experiences of discomfort and benefit. Ethics review committees,
      therefore, have little information about participant experiences to guide their
      informed decision-making. We asked undergraduate females about their experiences 
      in a study that included an experimental session, interviews, and self-report
      measures on sensitive topics. We examined results overall, and compared the
      responses of individuals with and without childhood abuse experiences.
      Participants who had experienced child abuse were more likely to report distress 
      due to remembering the past, but also more likely to report that participation
      was helpful. Implications for future research, and recommendations for review
      boards, are discussed.
FAU - Decker, Suzanne E
AU  - Decker SE
AD  - Department of Psychology, Western Michigan University, 1903 W. Michigan Avenue,
      Kalamazoo, MI 49008-5439, USA. amy.naugle@wmich.edu
FAU - Naugle, Amy E
AU  - Naugle AE
FAU - Carter-Visscher, Robin
AU  - Carter-Visscher R
FAU - Bell, Kathryn
AU  - Bell K
FAU - Seifert, Abby
AU  - Seifert A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biomedical Research/*ethics
MH  - Child
MH  - Child Abuse/ethics/*psychology
MH  - Decision Making
MH  - Emotions/*ethics
MH  - Ethics Committees, Research
MH  - Ethics, Research
MH  - Female
MH  - Guidelines as Topic
MH  - Humans
MH  - Interviews as Topic
MH  - Memory
MH  - Outcome Assessment, Health Care
MH  - *Patient Satisfaction
MH  - Research Subjects/*psychology
MH  - Self Disclosure
MH  - Self Report
MH  - *Stress, Psychological
MH  - Young Adult
EDAT- 2011/09/21 06:00
MHDA- 2012/02/23 06:00
CRDT- 2011/09/21 06:00
PHST- 2011/09/21 06:00 [entrez]
PHST- 2011/09/21 06:00 [pubmed]
PHST- 2012/02/23 06:00 [medline]
AID - 10.1525/jer.2011.6.3.55 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2011 Sep;6(3):55-64. doi: 10.1525/jer.2011.6.3.55.


PMID- 21931237
OWN - NLM
STAT- MEDLINE
DCOM- 20120222
LR  - 20110920
IS  - 1556-2654 (Electronic)
IS  - 1556-2646 (Linking)
VI  - 6
IP  - 3
DP  - 2011 Sep
TI  - When they hear what we say: ethical challenges in presenting research findings to
      the Huntington disease community.
PG  - 47-54
LID - 10.1525/jer.2011.6.3.47 [doi]
AB  - Sharing findings with the Huntington disease (HD) community and other genetic
      disease communities is challenging because of the sensitivity involved in
      effectively communicating findings to participants. We describe our experiences
      of presenting multi-disciplinary research findings to the HD community, and
      discuss the need to: (1) balance potential benefits and harms for participants,
      researchers, and others; (2) demonstrate respect for participants' needs,
      expectations, and priorities; and (3) ensure transparency and respect for
      autonomy.
FAU - Bombard, Yvonne
AU  - Bombard Y
AD  - Department of Health Policy Management and Evaluation, University of Toronto,
      Ontario, Canada.
FAU - Cox, Susan M
AU  - Cox SM
FAU - Semaka, Alicia
AU  - Semaka A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Biomedical Research/*ethics
MH  - *Communication
MH  - Ethics, Research
MH  - Humans
MH  - *Huntington Disease
MH  - *Personal Autonomy
MH  - *Professional-Patient Relations
MH  - Research Personnel
MH  - *Research Subjects
EDAT- 2011/09/21 06:00
MHDA- 2012/02/23 06:00
CRDT- 2011/09/21 06:00
PHST- 2011/09/21 06:00 [entrez]
PHST- 2011/09/21 06:00 [pubmed]
PHST- 2012/02/23 06:00 [medline]
AID - 10.1525/jer.2011.6.3.47 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2011 Sep;6(3):47-54. doi: 10.1525/jer.2011.6.3.47.


PMID- 21931233
OWN - NLM
STAT- MEDLINE
DCOM- 20120222
LR  - 20211020
IS  - 1556-2654 (Electronic)
IS  - 1556-2646 (Linking)
VI  - 6
IP  - 3
DP  - 2011 Sep
TI  - A framework for assessing the quality of democratic deliberation: enhancing
      deliberation as a tool for bioethics.
PG  - 3-17
LID - 10.1525/jer.2011.6.3.3 [doi]
AB  - The goal of democratic deliberation (DD) bioethics research is to elicit informed
      and considered opinions on ethically controversial issues. But the
      trustworthiness of DD outcomes depends on the quality of deliberations. We
      provide a framework to evaluate the quality of deliberations and apply that
      framework to a DD project on surrogate consent for dementia research involving
      randomly selected samples of the older general public. Using a mixed method
      approach, we found that participants were very satisfied with the sessions,
      learned and used new information, were respectful and collaborative, and were
      able to "reason together" to arrive at societal policy recommendations.
      Implications and limitations of the paper are also discussed.
FAU - De Vries, Raymond
AU  - De Vries R
AD  - Center for Bioethics and Social Sciences in Medicine, University of Michigan, 300
      North Ingalls Street, Ann Arbor, MI 48109, USA.
FAU - Stanczyk, Aimee E
AU  - Stanczyk AE
FAU - Ryan, Kerry A
AU  - Ryan KA
FAU - Kim, Scott Y H
AU  - Kim SY
LA  - eng
GR  - R01 AG029550/AG/NIA NIH HHS/United States
GR  - R01 AG029550-01A1/AG/NIA NIH HHS/United States
GR  - R01AG029550/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Aged
MH  - Attitude
MH  - *Bioethical Issues
MH  - Biomedical Research/ethics
MH  - *Community Participation
MH  - *Dementia
MH  - Democracy
MH  - *Ethics, Research
MH  - Humans
MH  - *Informed Consent
MH  - Middle Aged
MH  - Policy Making
MH  - *Public Opinion
MH  - *Public Policy
PMC - PMC3336203
MID - NIHMS369343
EDAT- 2011/09/21 06:00
MHDA- 2012/02/23 06:00
CRDT- 2011/09/21 06:00
PHST- 2011/09/21 06:00 [entrez]
PHST- 2011/09/21 06:00 [pubmed]
PHST- 2012/02/23 06:00 [medline]
AID - 10.1525/jer.2011.6.3.3 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2011 Sep;6(3):3-17. doi: 10.1525/jer.2011.6.3.3.


PMID- 21931092
OWN - NLM
STAT- MEDLINE
DCOM- 20120118
LR  - 20120924
IS  - 1538-3660 (Electronic)
IS  - 1521-2491 (Linking)
VI  - 13
IP  - 5
DP  - 2011 Sep-Oct
TI  - Health care reform: ethical considerations for physicians.
PG  - 359-61
LID - 10.1001/archfacial.2011.50 [doi]
FAU - Holt, G Richard
AU  - Holt GR
AD  - The Center for Medical Humanities and Ethics, The University of Texas Health
      Science Center, San Antonio, TX 78229, USA. holtg@uthscsa.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Arch Facial Plast Surg
JT  - Archives of facial plastic surgery
JID - 100883500
SB  - IM
MH  - *Ethics, Medical
MH  - Humans
MH  - *Patient Protection and Affordable Care Act/ethics
MH  - Patient-Centered Care
MH  - Physician-Patient Relations
MH  - Social Justice
MH  - United States
EDAT- 2011/09/21 06:00
MHDA- 2012/01/19 06:00
CRDT- 2011/09/21 06:00
PHST- 2011/09/21 06:00 [entrez]
PHST- 2011/09/21 06:00 [pubmed]
PHST- 2012/01/19 06:00 [medline]
AID - 13/5/359 [pii]
AID - 10.1001/archfacial.2011.50 [doi]
PST - ppublish
SO  - Arch Facial Plast Surg. 2011 Sep-Oct;13(5):359-61. doi:
      10.1001/archfacial.2011.50.


PMID- 21930539
OWN - NLM
STAT- MEDLINE
DCOM- 20111130
LR  - 20220410
IS  - 1098-4275 (Electronic)
IS  - 0031-4005 (Linking)
VI  - 128
IP  - 4
DP  - 2011 Oct
TI  - Challenges in setting up pediatric and neonatal intensive care units in a
      resource-limited country.
PG  - e986-92
LID - 10.1542/peds.2010-3657 [doi]
AB  - In collaboration with a host country and international medical volunteers, a PICU
      and an NICU were conceptualized and realized in the developing country of Nepal. 
      We present here the challenges that were encountered during and after the
      establishment of these units. The decision to develop an ICU with reasonable
      goals in a developing country has to be made with careful assessments of need of 
      that patient population and ethical principles guiding appropriate use of limited
      resources. Considerations during unit design include space allocation, limited
      supply of electricity, oxygen source, and clean-water availability. Budgetary
      challenges might place overall sustainability at stake, which can also lead to
      attrition of trained manpower and affect the quality of care. Those working in
      the PICU in resource-poor nations perpetually face the challenges of lack of
      expert support (subspecialists), diagnostic facilities (laboratory and
      radiology), and appropriate medications and equipment. Increasing transfer of
      severely ill patients from other health facilities can lead to space constraints,
      and lack of appropriate transportation for these critically ill patients
      increases the severity of illness, which leads to increased mortality rates. The 
      staff in these units must make difficult decisions on effective triage of
      admissions to the units on the basis of individual cases, futility of care,
      availability of resources, and financial ability of the family.
FAU - Basnet, Sangita
AU  - Basnet S
AD  - Division of Pediatric Critical Care, Department of Pediatrics, Southern Illinois 
      University School of Medicine, Springfield, Illinois 62794-9676, USA.
      sbasnet@siumed.edu
FAU - Adhikari, Neelam
AU  - Adhikari N
FAU - Koirala, Janak
AU  - Koirala J
LA  - eng
PT  - Journal Article
DEP - 20110919
PL  - United States
TA  - Pediatrics
JT  - Pediatrics
JID - 0376422
SB  - IM
MH  - Child
MH  - *Developing Countries
MH  - Education, Nursing, Continuing
MH  - Electricity
MH  - Equipment and Supplies, Hospital/economics/supply & distribution
MH  - Health Care Rationing
MH  - *Health Planning
MH  - Hospital Volunteers
MH  - Humans
MH  - Infant, Newborn
MH  - Intensive Care Units, Neonatal/organization & administration
MH  - Intensive Care Units, Pediatric/economics/*organization & administration
MH  - Nepal
MH  - Outcome Assessment, Health Care
MH  - Personnel Selection
MH  - Transportation of Patients
MH  - Water Supply
MH  - Workforce
EDAT- 2011/09/21 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/09/21 06:00
PHST- 2011/09/21 06:00 [entrez]
PHST- 2011/09/21 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - peds.2010-3657 [pii]
AID - 10.1542/peds.2010-3657 [doi]
PST - ppublish
SO  - Pediatrics. 2011 Oct;128(4):e986-92. doi: 10.1542/peds.2010-3657. Epub 2011 Sep
      19.


PMID- 21929821
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 2110-5820 (Electronic)
IS  - 2110-5820 (Linking)
VI  - 1
DP  - 2011 Sep 19
TI  - Pilot proof of concept clinical trials of Stochastic Targeted (STAR) glycemic
      control.
PG  - 38
LID - 10.1186/2110-5820-1-38 [doi]
AB  - INTRODUCTION: Tight glycemic control (TGC) has shown benefits but has been
      difficult to achieve consistently. STAR (Stochastic TARgeted) is a flexible,
      model-based TGC approach directly accounting for intra- and inter- patient
      variability with a stochastically derived maximum 5% risk of blood glucose (BG) <
      4.0 mmol/L. This research assesses the safety, efficacy, and clinical burden of a
      STAR TGC controller modulating both insulin and nutrition inputs in pilot trials.
      METHODS: Seven patients covering 660 hours. Insulin and nutrition interventions
      are given 1-3 hourly as chosen by the nurse to allow them to manage workload.
      Interventions are calculated by using clinically validated computer models of
      human metabolism and its variability in critical illness to maximize the overlap 
      of the model-predicted (5-95th percentile) range of BG outcomes with the 4.0-6.5 
      mmol/L band while ensuring a maximum 5% risk of BG < 4.0 mmol/L. Carbohydrate
      intake (all sources) was selected to maximize intake up to 100% of SCCM/ACCP goal
      (25 kg/kcal/h). Maximum insulin doses and dose changes were limited for safety.
      Measurements were made with glucometers. Results are compared to those for the
      SPRINT study, which reduced mortality 25-40% for length of stay >/=3 days.
      Written informed consent was obtained for all patients, and approval was granted 
      by the NZ Upper South A Regional Ethics Committee. RESULTS: A total of 402
      measurements were taken over 660 hours (~14/day), because nurses showed a
      preference for 2-hourly measurements. Median [interquartile range, (IQR)] cohort 
      BG was 5.9 mmol/L [5.2-6.8]. Overall, 63.2%, 75.9%, and 89.8% of measurements
      were in the 4.0-6.5, 4.0-7.0, and 4.0-8.0 mmol/L bands. There were no
      hypoglycemic events (BG < 2.2 mmol/L), and the minimum BG was 3.5 mmol/L with
      4.5% < 4.4 mmol/L. Per patient, the median [IQR] hours of TGC was 92 h [29-113]
      using 53 [19-62] measurements (median, ~13/day). Median [IQR] results: BG, 5.9
      mmol/L [5.8-6.3]; carbohydrate nutrition, 6.8 g/h [5.5-8.7] (~70% goal feed
      median); insulin, 2.5 U/h [0.1-5.1]. All patients achieved BG < 6.1 mmol/L. These
      results match or exceed SPRINT and clinical workload is reduced more than 20%.
      CONCLUSIONS: STAR TGC modulating insulin and nutrition inputs provided very tight
      control with minimal variability by managing intra- and inter- patient
      variability. Performance and safety exceed that of SPRINT, which reduced
      mortality and cost in the Christchurch ICU. The use of glucometers did not appear
      to impact the quality of TGC. Finally, clinical workload was self-managed and
      reduced 20% compared with SPRINT.
FAU - Evans, Alicia
AU  - Evans A
AD  - Department of Mechanical Engineering, Centre for Bio-Engineering, University of
      Canterbury, Christchurch, New Zealand. geoff.chase@canterbury.ac.nz.
FAU - Shaw, Geoffrey M
AU  - Shaw GM
FAU - Le Compte, Aaron
AU  - Le Compte A
FAU - Tan, Chia-Siong
AU  - Tan CS
FAU - Ward, Logan
AU  - Ward L
FAU - Steel, James
AU  - Steel J
FAU - Pretty, Christopher G
AU  - Pretty CG
FAU - Pfeifer, Leesa
AU  - Pfeifer L
FAU - Penning, Sophie
AU  - Penning S
FAU - Suhaimi, Fatanah
AU  - Suhaimi F
FAU - Signal, Matthew
AU  - Signal M
FAU - Desaive, Thomas
AU  - Desaive T
FAU - Chase, J Geoffrey
AU  - Chase JG
LA  - eng
PT  - Journal Article
DEP - 20110919
PL  - Germany
TA  - Ann Intensive Care
JT  - Annals of intensive care
JID - 101562873
PMC - PMC3224394
EDAT- 2011/09/21 06:00
MHDA- 2011/09/21 06:01
CRDT- 2011/09/21 06:00
PHST- 2011/05/18 00:00 [received]
PHST- 2011/09/19 00:00 [accepted]
PHST- 2011/09/21 06:00 [entrez]
PHST- 2011/09/21 06:00 [pubmed]
PHST- 2011/09/21 06:01 [medline]
AID - 2110-5820-1-38 [pii]
AID - 10.1186/2110-5820-1-38 [doi]
PST - epublish
SO  - Ann Intensive Care. 2011 Sep 19;1:38. doi: 10.1186/2110-5820-1-38.


PMID- 21929765
OWN - NLM
STAT- MEDLINE
DCOM- 20120822
LR  - 20211020
IS  - 1466-609X (Electronic)
IS  - 1364-8535 (Linking)
VI  - 15
IP  - 5
DP  - 2011
TI  - Preoperative regional cerebral oxygen saturation is a predictor of postoperative 
      delirium in on-pump cardiac surgery patients: a prospective observational trial.
PG  - R218
LID - 10.1186/cc10454 [doi]
AB  - INTRODUCTION: Postoperative delirium is an important problem in patients
      undergoing major surgery. Cerebral oximetry is a non-invasive method to detect
      imbalances in the cerebral oxygen supply/demand-ratio. Low preoperative cerebral 
      oxygen saturation (ScO(2)) levels have been associated with postoperative
      delirium in non-cardiac surgery patients. The present prospective observational
      study determines the relationship between pre- and intra-operative ScO(2) levels 
      and postoperative delirium in patients undergoing on-pump cardiac surgery.
      METHODS: After approval of the local ethical committee and written informed
      consent, N = 231 patients scheduled for elective/urgent cardiac surgery were
      enrolled. Delirium was assessed by the confusion-assessment-method for the
      intensive care unit (CAM-ICU) on the first three days after surgery. ScO(2) was
      obtained on the day before surgery, immediately before surgery and throughout the
      surgical procedure. Preoperative cognitive function, demographic, surgery
      related, and intra- and post-operative physiological data were registered.
      RESULTS: Patients with delirium had lower pre- and intra-operative ScO(2)
      readings, were older, had lower mini-mental-status-examination(MMSE) scores,
      higher additive EuroScore and lower preoperative haemoglobin-levels. The binary
      logistic regression identified older age, lower MMSE, neurological or psychiatric
      disease and lower preoperative ScO(2) as independent predictors of postoperative 
      delirium. CONCLUSIONS: The presented study shows that a low preoperative ScO(2)
      is associated with postoperative delirium after on-pump cardiac surgery.
FAU - Schoen, Julika
AU  - Schoen J
AD  - Department of Anaesthesiology, University of Luebeck, Ratzeburger Allee 160,
      Luebeck, 23538, Germany.
FAU - Meyerrose, Joscha
AU  - Meyerrose J
FAU - Paarmann, Hauke
AU  - Paarmann H
FAU - Heringlake, Matthias
AU  - Heringlake M
FAU - Hueppe, Michael
AU  - Hueppe M
FAU - Berger, Klaus-Ulrich
AU  - Berger KU
LA  - eng
PT  - Journal Article
DEP - 20110919
PL  - England
TA  - Crit Care
JT  - Critical care (London, England)
JID - 9801902
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Aged
MH  - Cardiac Surgical Procedures/*adverse effects
MH  - Cerebrum/*metabolism
MH  - Delirium/*etiology
MH  - Female
MH  - Heart-Assist Devices
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oximetry
MH  - Oxygen/*metabolism
MH  - Predictive Value of Tests
MH  - Prospective Studies
PMC - PMC3334763
EDAT- 2011/09/21 06:00
MHDA- 2012/08/23 06:00
CRDT- 2011/09/21 06:00
PHST- 2011/05/25 00:00 [received]
PHST- 2011/07/22 00:00 [revised]
PHST- 2011/09/19 00:00 [accepted]
PHST- 2011/09/21 06:00 [entrez]
PHST- 2011/09/21 06:00 [pubmed]
PHST- 2012/08/23 06:00 [medline]
AID - cc10454 [pii]
AID - 10.1186/cc10454 [doi]
PST - ppublish
SO  - Crit Care. 2011;15(5):R218. doi: 10.1186/cc10454. Epub 2011 Sep 19.


PMID- 21929707
OWN - NLM
STAT- MEDLINE
DCOM- 20120131
LR  - 20110920
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 25
IP  - 8
DP  - 2011 Oct
TI  - Human and animal research guidelines: aligning ethical constructs with new
      scientific developments.
PG  - 472-8
LID - 10.1111/j.1467-8519.2011.01923.x [doi]
AB  - Both human research and animal research operate within established standards and 
      procedures. Although the human research environment has been criticized for its
      sometimes inefficient and imperfect process, reported abuses of human subjects in
      research served as the impetus for the establishment of the Nuremberg Code,
      Declaration of Helsinki, and the National Commission for the Protection of Human 
      Subjects of Biomedical and Behavioral Research and the resulting Belmont Report. 
      No similar, comprehensive and principled effort has addressed the use of animals 
      in research. Although published policies regarding animal research provide
      relevant regulatory guidance, these policies have not emerged from the process of
      specifying consistent and reasoned ethical principles. The lack of a fundamental 
      effort to explore the ethical issues and principles regarding the use of animals 
      in research has led to unclear and disparate policies. Recent studies have
      increased our understanding of animal cognition and emotion, suggesting that
      animals' potential for experiencing a wide variety of harms, such as pain and
      fear, is greater than has been previously appreciated. Furthermore, relationships
      between methods of captivity and certain laboratory procedures and the resulting 
      adverse physical, social and psychological effects have been established. In
      light of this information, current protections may need to be reconsidered and
      modified. This paper explores the historical convergence and divergence in the
      creation of human and animal research guidelines, as well as opportunities to
      align ethical frameworks with new scientific discoveries.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Ferdowsian, Hope
AU  - Ferdowsian H
AD  - Washington, DC 20016, USA. hopeferdowsian@sprintmail.com
LA  - eng
PT  - Journal Article
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Animal Experimentation/*ethics/legislation & jurisprudence
MH  - Animals
MH  - *Codes of Ethics
MH  - *Guidelines as Topic
MH  - Human Experimentation/*ethics/legislation & jurisprudence
MH  - Humans
MH  - *Public Policy
EDAT- 2011/09/21 06:00
MHDA- 2012/02/01 06:00
CRDT- 2011/09/21 06:00
PHST- 2011/09/21 06:00 [entrez]
PHST- 2011/09/21 06:00 [pubmed]
PHST- 2012/02/01 06:00 [medline]
AID - 10.1111/j.1467-8519.2011.01923.x [doi]
PST - ppublish
SO  - Bioethics. 2011 Oct;25(8):472-8. doi: 10.1111/j.1467-8519.2011.01923.x.


PMID- 21929703
OWN - NLM
STAT- MEDLINE
DCOM- 20120131
LR  - 20110920
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 25
IP  - 8
DP  - 2011 Oct
TI  - Ethical reasoning in pandemic preparedness plans: Southeast Asia and the Western 
      Pacific.
PG  - 445-50
LID - 10.1111/j.1467-8519.2011.01922.x [doi]
AB  - The emergence of H1N1 in 2009 shows that it is a mistake to regard the scenario
      of having to implement pandemic plans as merely hypothetical. This recent
      experience provides an opportunity to inquire into the current state of pandemic 
      preparedness plans with regard to their ethical adequacy. One aspect that
      deserves consideration in this context is the disclosure of ethical reasoning.
      Accordingly, the following is an analysis of examples of pandemic plans and
      drafts of plans from Southeast Asia and the Western Pacific. It is an analysis of
      the occurrence of explicit ethical reflection in these documents as well an
      inquiry into the related question of how ethical reflection can be understood as 
      a constitutive element of ethical pandemic preparedness. In the analysis,
      different fields of ethical consideration concerning equity, personal rights and 
      accountability are distinguished. There are both pragmatic and genuinely ethical 
      reasons to explicitly address issues of these types in pandemic plans. The extent
      to which ethical language appears in the national plans in South East Asia and
      the Western Pacific suggests that there is limited awareness of ethical
      considerations, or at least insufficient ethical substantiation of pandemic
      action. The aim of the analysis is to show that further inclusion of ethical
      considerations into pandemic plans is ethically demanded. It is of particular
      significance that these considerations are formulated and remain discernible as
      instances of ethical deliberation.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Derpmann, Simon
AU  - Derpmann S
AD  - Westfalische Wilhelms-Universitat Munster, Philosophisches Seminar Domplatz,
      Germany. simon.derpmann@uni-muenster.de
LA  - eng
PT  - Journal Article
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Asia
MH  - Asia, Southeastern
MH  - Australasia
MH  - *Disaster Planning
MH  - Ethical Analysis
MH  - Health Planning/*ethics
MH  - *Human Rights
MH  - Humans
MH  - *Influenza A Virus, H1N1 Subtype
MH  - Influenza, Human/epidemiology/*prevention & control
MH  - Pandemics/*prevention & control
MH  - Social Responsibility
MH  - Terminology as Topic
EDAT- 2011/09/21 06:00
MHDA- 2012/02/01 06:00
CRDT- 2011/09/21 06:00
PHST- 2011/09/21 06:00 [entrez]
PHST- 2011/09/21 06:00 [pubmed]
PHST- 2012/02/01 06:00 [medline]
AID - 10.1111/j.1467-8519.2011.01922.x [doi]
PST - ppublish
SO  - Bioethics. 2011 Oct;25(8):445-50. doi: 10.1111/j.1467-8519.2011.01922.x.


PMID- 21929702
OWN - NLM
STAT- MEDLINE
DCOM- 20120131
LR  - 20110920
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 25
IP  - 8
DP  - 2011 Oct
TI  - The harm principle as a mid-level principle?: three problems from the context of 
      infectious disease control.
PG  - 437-44
LID - 10.1111/j.1467-8519.2011.01926.x [doi]
AB  - Effective infectious disease control may require states to restrict the liberty
      of individuals. Since preventing harm to others is almost universally accepted as
      a legitimate (prima facie) reason for restricting the liberty of individuals, it 
      seems plausible to employ a mid-level harm principle in infectious disease
      control. Moral practices like infectious disease control support - or even
      require - a certain level of theory-modesty. However, employing a mid-level harm 
      principle in infectious disease control faces at least three problems. First, it 
      is unclear what we gain by attaining convergence on a specific formulation of the
      harm principle. Likely candidates for convergence, a harm principle aimed at
      preventing harmful conduct, supplemented by considerations of effectiveness and
      always choosing the least intrusive means still leave ample room for normative
      disagreement. Second, while mid-level principles are sometimes put forward in
      response to the problem of normative theories attaching different weight to moral
      principles, employing a mid-level harm principle completely leaves open how to
      determine what weight to attach to it in application. Third, there appears to be 
      a trade-off between attaining convergence and finding a formulation of the harm
      principle that can justify liberty-restrictions in all situations of contagion,
      including interventions that are commonly allowed. These are not reasons to
      abandon mid-level theorizing altogether. But there is no reason to be too
      theory-modest in applied ethics. Morally justifying e.g. if a liberty-restriction
      in infectious disease control is proportional to the aim of harm-prevention,
      promptly requires moving beyond the mid-level harm principle.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Krom, Andre
AU  - Krom A
AD  - Utrecht University, Department of Philosophy, Ethics Institute, The Netherlands. 
      a.krom@uu.nl
LA  - eng
PT  - Journal Article
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Coercion
MH  - *Communicable Disease Control
MH  - Humans
MH  - Mandatory Programs/*ethics
MH  - Mass Vaccination/ethics
MH  - *Principle-Based Ethics
EDAT- 2011/09/21 06:00
MHDA- 2012/02/01 06:00
CRDT- 2011/09/21 06:00
PHST- 2011/09/21 06:00 [entrez]
PHST- 2011/09/21 06:00 [pubmed]
PHST- 2012/02/01 06:00 [medline]
AID - 10.1111/j.1467-8519.2011.01926.x [doi]
PST - ppublish
SO  - Bioethics. 2011 Oct;25(8):437-44. doi: 10.1111/j.1467-8519.2011.01926.x.


PMID- 21929701
OWN - NLM
STAT- MEDLINE
DCOM- 20120131
LR  - 20181201
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 25
IP  - 8
DP  - 2011 Oct
TI  - IAB presidential address: bioethics in a globalized world: creating space for
      flourishing human relationships.
PG  - 430-6
LID - 10.1111/j.1467-8519.2011.01927.x [doi]
AB  - Bioethics in a globalized world is meeting a number of challenges -
      fundamentalism in its different forms, and a focus on economic growth neglecting 
      issues such as equity and sustainability, being prominent among them. How well
      are we as bioethicists equipped to make meaningful contributions in these times? 
      The paper identifies a number of restraints and proceeds to probe potential
      resources such as the capability approach, care ethics, cosmopolitanism, and
      pragmatism. These elements serve to outline a perspective that focuses on the
      preconditions for flourishing human relationships as a way to address bioethical 
      challenges in a globalized world.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Biller-Andorno, Nikola
AU  - Biller-Andorno N
AD  - University of Zurich, Institute of Biomedical Ethics, Switzerland.
      biller-andorno@ethik.uzh.ch
LA  - eng
PT  - Address
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Bioethics/*trends
MH  - Cultural Diversity
MH  - Economic Recession
MH  - *Human Rights
MH  - Humans
MH  - *Internationality
MH  - *Interpersonal Relations
MH  - *Professional Role
MH  - Social Justice
EDAT- 2011/09/21 06:00
MHDA- 2012/02/01 06:00
CRDT- 2011/09/21 06:00
PHST- 2011/09/21 06:00 [entrez]
PHST- 2011/09/21 06:00 [pubmed]
PHST- 2012/02/01 06:00 [medline]
AID - 10.1111/j.1467-8519.2011.01927.x [doi]
PST - ppublish
SO  - Bioethics. 2011 Oct;25(8):430-6. doi: 10.1111/j.1467-8519.2011.01927.x.


PMID- 21929542
OWN - NLM
STAT- MEDLINE
DCOM- 20120418
LR  - 20111205
IS  - 1479-828X (Electronic)
IS  - 0004-8666 (Linking)
VI  - 51
IP  - 6
DP  - 2011 Dec
TI  - The ethics of obtaining consent in labour for research.
PG  - 485-92
LID - 10.1111/j.1479-828X.2011.01341.x [doi]
AB  - BACKGROUND: It is widely acknowledged that the pregnant population is a
      vulnerable and potentially disadvantaged one with regard to research. We sought
      to evaluate compliance with this concept by examining current Australian
      practices of obtaining consent for research during labour through the published
      literature and from Australian Human Research Ethics Committees (HRECs) as well
      as reviewing the relevant literature. METHODS: We surveyed Australian HRECs
      requesting information about their opinions and/or practices surrounding the
      ethics of research consent during labour or birth. In addition, a literature
      search was performed to find randomised controlled trials (RCTs) involving
      interventions during labour in Australia in the last five years. RESULTS: Of the 
      HREC respondents, 75% believed it to be ethical to obtain consent for research in
      labour, 87% would require additional expert assistance to approve, 57% felt the
      partner should be involved and all proposed research scenarios were thought to
      require protocol changes. Recent local RCTs reflected a variety of consent
      strategies, each having their limitations. CONCLUSIONS: An under-used but
      potentially useful strategy may be staged recruitment and consent. Despite the
      evidence supporting labour as a time requiring increased acuity for informed
      consent, there is little to suggest that this knowledge is being applied to
      current Australian HREC and RCT practices. We suggest that further practical
      guidelines be devised to aid researchers and human ethics committees.
CI  - (c) 2011 The Authors. Australian and New Zealand Journal of Obstetrics and
      Gynaecology (c) 2011 The Royal Australian and New Zealand College of
      Obstetricians and Gynaecologists.
FAU - Reid, Rachel
AU  - Reid R
AD  - Department of Midwifery, Royal Hospital for Women, Randwick Faculty of Medicine, 
      University of New South Wales, Randwick, New South Wales, Australia.
FAU - Susic, Daniella
AU  - Susic D
FAU - Pathirana, Shanthi
AU  - Pathirana S
FAU - Tracy, Sally
AU  - Tracy S
FAU - Welsh, Alec W
AU  - Welsh AW
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110920
PL  - Australia
TA  - Aust N Z J Obstet Gynaecol
JT  - The Australian & New Zealand journal of obstetrics & gynaecology
JID - 0001027
SB  - IM
MH  - Australia
MH  - Biomedical Research/*ethics
MH  - Data Collection
MH  - Ethical Review
MH  - Ethics Committees, Research
MH  - Female
MH  - Humans
MH  - Informed Consent/*ethics
MH  - *Labor, Obstetric
MH  - Pregnancy
MH  - Randomized Controlled Trials as Topic/ethics
MH  - Third-Party Consent/ethics
EDAT- 2011/09/21 06:00
MHDA- 2012/04/19 06:00
CRDT- 2011/09/21 06:00
PHST- 2011/09/21 06:00 [entrez]
PHST- 2011/09/21 06:00 [pubmed]
PHST- 2012/04/19 06:00 [medline]
AID - 10.1111/j.1479-828X.2011.01341.x [doi]
PST - ppublish
SO  - Aust N Z J Obstet Gynaecol. 2011 Dec;51(6):485-92. doi:
      10.1111/j.1479-828X.2011.01341.x. Epub 2011 Sep 20.


PMID- 21929355
OWN - NLM
STAT- MEDLINE
DCOM- 20120424
LR  - 20161125
IS  - 1471-180X (Electronic)
IS  - 1471-180X (Linking)
VI  - 13
IP  - 1
DP  - 2012 Jan
TI  - Fast course ALS presenting with vocal cord paralysis: clinical features,
      bioinformatic and modelling analysis of the novel SOD1 Gly147Ser mutation.
PG  - 144-8
LID - 10.3109/17482968.2011.614254 [doi]
AB  - In this report we describe a novel SOD1 mutation (Gly147Ser) in an Italian
      sporadic ALS patient. The patient presented with hoarseness due to bilateral
      vocal cord paralysis and a rapid clinical course. Mutational analysis of the SOD1
      gene was carried out by direct sequencing. In silico bioinformatics analysis and 
      molecular modelling was used to analyse the SOD1 function modifications produced 
      by the mutated residue. A heterozygous c.442 G > A transition, which leads to a
      change at codon 147 resulting in a serine rather than glycine, was found in the
      patient. Bioinformatics analysis and molecular modelling strongly suggest a
      dramatic effect of Gly147Ser mutation on SOD1 function. In conclusion, Gly147Ser 
      represent a new missense mutation whose effect may correlate with the peculiar
      clinical bulbar phenotype onset with bilateral vocal cord paresis and rapid
      clinical course of the disease. Ethical and psychological dilemmas about genetic 
      testing in apparently sporadic subjects are still matter of debate.
FAU - Origone, Paola
AU  - Origone P
AD  - Department of Biology and Genetics, University of Genoa and U.O.C. Medical
      Genetics of Azienda Ospedaliera Universitaria S. Martino di Genova, Genoa, Italy.
FAU - Caponnetto, Claudia
AU  - Caponnetto C
FAU - Mantero, Vittorio
AU  - Mantero V
FAU - Cichero, Elena
AU  - Cichero E
FAU - Fossa, Paola
AU  - Fossa P
FAU - Geroldi, Alessandro
AU  - Geroldi A
FAU - Verdiani, Simonetta
AU  - Verdiani S
FAU - Bellone, Emilia
AU  - Bellone E
FAU - Mancardi, Gianluigi
AU  - Mancardi G
FAU - Mandich, Paola
AU  - Mandich P
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110919
PL  - England
TA  - Amyotroph Lateral Scler
JT  - Amyotrophic lateral sclerosis : official publication of the World Federation of
      Neurology Research Group on Motor Neuron Diseases
JID - 101283386
RN  - 0 (SOD1 protein, human)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 1.15.1.1 (Superoxide Dismutase-1)
SB  - IM
MH  - Amyotrophic Lateral
      Sclerosis/*complications/*enzymology/*genetics/physiopathology
MH  - Animals
MH  - *Computational Biology
MH  - DNA Mutational Analysis
MH  - Fatal Outcome
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Models, Molecular
MH  - Molecular Sequence Data
MH  - *Point Mutation
MH  - Protein Conformation
MH  - Sequence Alignment
MH  - Superoxide Dismutase/chemistry/*genetics/metabolism
MH  - Superoxide Dismutase-1
MH  - Vocal Cord Paralysis/*etiology
EDAT- 2011/09/21 06:00
MHDA- 2012/04/25 06:00
CRDT- 2011/09/21 06:00
PHST- 2011/09/21 06:00 [entrez]
PHST- 2011/09/21 06:00 [pubmed]
PHST- 2012/04/25 06:00 [medline]
AID - 10.3109/17482968.2011.614254 [doi]
PST - ppublish
SO  - Amyotroph Lateral Scler. 2012 Jan;13(1):144-8. doi: 10.3109/17482968.2011.614254.
      Epub 2011 Sep 19.


PMID- 21928920
OWN - NLM
STAT- MEDLINE
DCOM- 20120425
LR  - 20111129
IS  - 1939-1544 (Electronic)
IS  - 0090-5550 (Linking)
VI  - 56
IP  - 4
DP  - 2011 Nov
TI  - When is differential treatment discriminatory? Legal, ethical, and professional
      considerations for psychology trainees with disabilities.
PG  - 329-39
LID - 10.1037/a0025449 [doi]
AB  - PURPOSE: A supervisor may tell graduate trainees with obvious disabilities to
      disclose the disability to potential clients. Legal and ethical guidelines only
      partially address whether this requirement is permissible. Here we examine such
      disclosures from several vantage points. BACKGROUND: Professional judgments guide
      supervisors in deciding whether to request that a trainee disclose a disability. 
      The law provides little guidance to supervisors in making this decision. Instead,
      professional ethics and beliefs about disability drive decisions, and these
      beliefs may be prejudicial. METHOD: In this article, we examine whether it is
      good practice for a supervisor in a practicum or internship to require a trainee 
      with an obvious disability to disclose the disability to potential clients before
      the first meeting so that the client has freedom to request a different
      therapist. We use this situation to examine the pertinent legal standards;
      ethical guidelines; and clinical, professional, and social justice issues.
      CONCLUSION: The requirement of disclosure may not be in the best interests of the
      client and has deleterious repercussions for trainees with disabilities, their
      peers, and the profession. Unless addressed without prejudice, differential
      treatment becomes discriminatory and is an obstacle to successful completion of
      professional education by trainees with obvious disabilities.
FAU - Taube, Daniel O
AU  - Taube DO
AD  - California School of Professional Psychology, Alliant International University,
      San Francisco 94133, USA. dtaube@alliant.edu
FAU - Olkin, Rhoda
AU  - Olkin R
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110919
PL  - United States
TA  - Rehabil Psychol
JT  - Rehabilitation psychology
JID - 0365337
SB  - IM
MH  - Disabled Persons/education/*legislation & jurisprudence
MH  - *Ethics, Professional
MH  - Humans
MH  - Internship and Residency/ethics/legislation & jurisprudence
MH  - Judgment/ethics
MH  - *Prejudice
MH  - Psychology/education/*ethics/*legislation & jurisprudence
MH  - Self Disclosure
MH  - Students, Health Occupations/*legislation & jurisprudence
MH  - Truth Disclosure/*ethics
EDAT- 2011/09/21 06:00
MHDA- 2012/04/26 06:00
CRDT- 2011/09/21 06:00
PHST- 2011/09/21 06:00 [entrez]
PHST- 2011/09/21 06:00 [pubmed]
PHST- 2012/04/26 06:00 [medline]
AID - 2011-21073-001 [pii]
AID - 10.1037/a0025449 [doi]
PST - ppublish
SO  - Rehabil Psychol. 2011 Nov;56(4):329-39. doi: 10.1037/a0025449. Epub 2011 Sep 19.


PMID- 21928551
OWN - NLM
STAT- MEDLINE
DCOM- 20111101
LR  - 20110920
IS  - 0031-4617 (Print)
IS  - 0031-4617 (Linking)
VI  - 66
IP  - 2
DP  - 2011 Jun
TI  - Two heads are better than one: the future of patient safety and quality care.
PG  - 12-4
AB  - IPE summits can be used as a mechanism to have students from multiple disciplines
      explore ethical issues, define professional roles and responsibilities, and
      encourage interdisciplinary discussion. Students can be facilitated in this
      process through questions related to each member's role and scope of practice.
      The goals for students participating in these types of activities are to expand
      the students' knowledge of other health professions and to promote
      interprofessional understanding of other health professionals' roles and
      responsibilities to patient care. It is hopeful that students will reflect upon
      the identification of healthcare professional roles and responsibilities and use 
      such opportunities to collaborate in ways to improve patient outcomes.
FAU - Mailloux, Cynthia
AU  - Mailloux C
AD  - Nursing Department, Misericordia University, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pa Nurse
JT  - The Pennsylvania nurse
JID - 19540010R
MH  - *Education, Nursing
MH  - Humans
MH  - *Interdisciplinary Studies
MH  - *Patient Care Team
MH  - *Patient-Centered Care
MH  - Pennsylvania
MH  - *Safety Management
EDAT- 2011/09/21 06:00
MHDA- 2011/11/02 06:00
CRDT- 2011/09/21 06:00
PHST- 2011/09/21 06:00 [entrez]
PHST- 2011/09/21 06:00 [pubmed]
PHST- 2011/11/02 06:00 [medline]
PST - ppublish
SO  - Pa Nurse. 2011 Jun;66(2):12-4.


PMID- 21928323
OWN - NLM
STAT- MEDLINE
DCOM- 20120625
LR  - 20110929
IS  - 1539-1612 (Electronic)
IS  - 1539-1604 (Linking)
VI  - 10
IP  - 5
DP  - 2011 Sep-Oct
TI  - Designing a non-inferiority study in kidney transplantation: a case study.
PG  - 427-32
LID - 10.1002/pst.511 [doi]
AB  - In organ transplantation, placebo-controlled clinical trials are not possible for
      ethical reasons, and hence non-inferiority trials are used to evaluate new drugs.
      Patients with a transplanted kidney typically receive three to four
      immunosuppressant drugs to prevent organ rejection. In the described case of a
      non-inferiority trial for one of these immunosuppressants, the dose is changed,
      and another is replaced by an investigational drug. This test regimen is compared
      with the active control regimen. Justification for the non-inferiority margin is 
      challenging as the putative placebo has never been studied in a clinical trial.
      We propose the use of a random-effect meta-regression, where each
      immunosuppressant component of the regimen enters as a covariate. This allows us 
      to make inference on the difference between the putative placebo and the active
      control. From this, various methods can then be used to derive the
      non-inferiority margin. A hybrid of the 95/95 and synthesis approach is
      suggested. Data from 51 trials with a total of 17,002 patients were used in the
      meta-regression. Our approach was motivated by a recent large confirmatory trial 
      in kidney transplantation. The results and the methodological documents of this
      evaluation were submitted to the Food and Drug Administration. The Food and Drug 
      Administration accepted our proposed non-inferiority margin and our rationale.
CI  - Copyright (c) 2011 John Wiley & Sons, Ltd.
FAU - Witte, Steffen
AU  - Witte S
AD  - Novartis Pharma AG, Basel, Switzerland. steffen.witte@novartis.com
FAU - Schmidli, Heinz
AU  - Schmidli H
FAU - O'Hagan, Anthony
AU  - O'Hagan A
FAU - Racine, Amy
AU  - Racine A
LA  - eng
PT  - Journal Article
DEP - 20110916
PL  - England
TA  - Pharm Stat
JT  - Pharmaceutical statistics
JID - 101201192
RN  - 0 (Drugs, Investigational)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Placebos)
SB  - IM
MH  - Bayes Theorem
MH  - Confidence Intervals
MH  - Control Groups
MH  - Drugs, Investigational/adverse effects/metabolism/pharmacology
MH  - Humans
MH  - Immunosuppressive Agents/adverse effects/metabolism/pharmacology
MH  - Kidney Transplantation/*statistics & numerical data
MH  - Likelihood Functions
MH  - Meta-Analysis as Topic
MH  - *Models, Statistical
MH  - Placebos
MH  - Randomized Controlled Trials as Topic/*methods/statistics & numerical data
MH  - Research Design/*statistics & numerical data
MH  - Treatment Outcome
MH  - United States
MH  - United States Food and Drug Administration/statistics & numerical data
EDAT- 2011/09/20 06:00
MHDA- 2012/06/26 06:00
CRDT- 2011/09/20 06:00
PHST- 2011/03/29 00:00 [received]
PHST- 2011/07/19 00:00 [revised]
PHST- 2011/07/19 00:00 [accepted]
PHST- 2011/09/20 06:00 [entrez]
PHST- 2011/09/20 06:00 [pubmed]
PHST- 2012/06/26 06:00 [medline]
AID - 10.1002/pst.511 [doi]
PST - ppublish
SO  - Pharm Stat. 2011 Sep-Oct;10(5):427-32. doi: 10.1002/pst.511. Epub 2011 Sep 16.


PMID- 21927783
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20110919
IS  - 1945-404X (Electronic)
IS  - 0090-7421 (Linking)
VI  - 40
IP  - 3
DP  - 2011 Fall
TI  - Research in the allied health professions: why fund it? A report of the ASAHP
      Research Committee.
PG  - 161-6
AB  - Many professionals work closely with physicians and nurses to provide healthcare 
      that is safe, patient-centered, efficient, equitable, timely, and effective.
      These professionals represent many and varied allied health disciplines. Each
      allied health professional is ethically accountable for bringing a
      theoretically-sound and evidence-based approach to problem-solving in healthcare 
      delivery. Although allied health research is in its infancy, the breadth and
      depth of its potential contributions to effective healthcare research and its
      interprofessional application may be under-recognized, particularly by funding
      agencies. The purpose of this paper is to define allied health, clarify its
      theoretical and scientific foundation, emphasize the breadth of its application
      to evidence-based practice, and document its relevance to, and suitability for,
      funding through national organizations.
FAU - Arena, Ross A
AU  - Arena RA
AD  - University of New Mexico, Albuquerque, New Mexico, USA.
FAU - Goldberg, Lynette R
AU  - Goldberg LR
FAU - Ingersoll, Christopher D
AU  - Ingersoll CD
FAU - Larsen, Deborah S
AU  - Larsen DS
FAU - Shelledy, David
AU  - Shelledy D
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Allied Health
JT  - Journal of allied health
JID - 0361603
SB  - IM
MH  - *Allied Health Occupations
MH  - Evidence-Based Practice
MH  - Humans
MH  - *Research Support as Topic
MH  - United States
EDAT- 2011/09/20 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/09/20 06:00
PHST- 2011/08/10 00:00 [accepted]
PHST- 2011/09/20 06:00 [entrez]
PHST- 2011/09/20 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
PST - ppublish
SO  - J Allied Health. 2011 Fall;40(3):161-6.


PMID- 21926531
OWN - NLM
STAT- MEDLINE
DCOM- 20120131
LR  - 20110919
IS  - 1538-1145 (Electronic)
IS  - 1527-4160 (Linking)
VI  - 17
IP  - 5
DP  - 2011 Sep
TI  - Writing reports for lawyers and courts.
PG  - 355-9
LID - 10.1097/01.pra.0000405366.74796.f1 [doi]
AB  - Psychiatrists and other mental health professionals are asked from time to time
      to provide reports that will be used in legal or administrative actions
      ("forensic" reports, expressing "opinions" beyond personal observations). This
      article provides general guidance and recommendations for forensic report
      writing, particularly when the writer has limited forensic experience. Forensic
      reports are quite different from ordinary clinical reports. Their appearance,
      purpose, context, format, vocabulary, and legal or administrative "rules" should 
      be carefully considered by professionals who choose to write them. Conflict of
      interest dictates that most such reports not be written about one's own patients.
      Requests from complainants or litigants themselves, rather than from lawyers,
      judges, or agency/company officials, should usually be declined. Although most
      attorneys and others who ask for reports do so in good faith, some requests,
      especially last-minute or "rush" demands and those from complainants or litigants
      themselves, can encourage misguided or even unethical behavior. Clinicians who
      write forensic reports should adhere to a careful routine of completeness,
      honesty, and objectivity. They should decline cases in which they sense
      inappropriate pressure or ethical problems, and treat every report as a lasting
      and public example of their work, expertise, and professionalism.
FAU - Reid, William H
AU  - Reid WH
LA  - eng
PT  - Editorial
PL  - United States
TA  - J Psychiatr Pract
JT  - Journal of psychiatric practice
JID - 100901141
SB  - IM
MH  - *Forensic Psychiatry
MH  - Humans
MH  - *Research Report
MH  - *Writing
EDAT- 2011/09/20 06:00
MHDA- 2012/02/01 06:00
CRDT- 2011/09/20 06:00
PHST- 2011/09/20 06:00 [entrez]
PHST- 2011/09/20 06:00 [pubmed]
PHST- 2012/02/01 06:00 [medline]
AID - 10.1097/01.pra.0000405366.74796.f1 [doi]
AID - 00131746-201109000-00007 [pii]
PST - ppublish
SO  - J Psychiatr Pract. 2011 Sep;17(5):355-9. doi: 10.1097/01.pra.0000405366.74796.f1.


PMID- 21926447
OWN - NLM
STAT- MEDLINE
DCOM- 20120501
LR  - 20211020
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 2
IP  - 9
DP  - 2011 Sep
TI  - Human amniotic fluid stem cells as a model for functional studies of genes
      involved in human genetic diseases or oncogenesis.
PG  - 705-12
AB  - Besides their putative usage for therapies, stem cells are a promising tool for
      functional studies of genes involved in human genetic diseases or oncogenesis.
      For this purpose induced pluripotent stem (iPS) cells can be derived from
      patients harbouring specific mutations. In contrast to adult stem cells, iPS
      cells are pluripotent and can efficiently be grown in culture. However, iPS cells
      are modulated due to the ectopic induction of pluripotency, harbour other somatic
      mutations accumulated during the life span of the source cells, exhibit only
      imperfectly cleared epigenetic memory of the source cell, and are often
      genomically instable. In addition, iPS cells from patients only allow the
      investigation of mutations, which are not prenatally lethal. Embryonic stem (ES) 
      cells have a high proliferation and differentiation potential, but raise ethical 
      issues. Human embryos, which are not transferred in the course of in vitro
      fertilization, because of preimplantation genetic diagnosis of a genetic defect, 
      are still rarely donated for the establishment of ES cell lines. In addition,
      their usage for studies on gene functions for oncogenesis is hampered by the fact
      the ES cells are already tumorigenic per se. In 2003 amniotic fluid stem (AFS)
      cells have been discovered, which meanwhile have been demonstrated to harbour the
      potential to differentiate into cells of all three germ layers. Monoclonal human 
      AFS cell lines derived from amniocenteses have a high proliferative potential,
      are genomically stable and are not associated with ethical controversies.
      Worldwide amniocenteses are performed for routine human genetic diagnosis. We
      here discuss how generation and banking of monoclonal human AFS cell lines with
      specific chromosomal aberrations or monogenic disease mutations would allow to
      study the functional consequences of disease causing mutations. In addition,
      recently a protocol for efficient and highly reproducible siRNA-mediated
      long-term knockdown of endogenous gene functions in AFS cells was established.
      Since AFS cells are not tumorigenic, gene modulations not only allow to
      investigate the role of endogenous genes involved in human genetic diseases but
      also may help to reveal putative oncogenic gene functions in different biological
      models, both in vitro and in vivo. This concept is discussed and a "proof of
      principle", already obtained via modulating genes involved in the mammalian
      target of rapamycin (mTOR) pathway in AFS cells, is presented.
FAU - Rosner, Margit
AU  - Rosner M
AD  - Medical Genetics, Medical University of Vienna, Austria.
FAU - Dolznig, Helmut
AU  - Dolznig H
FAU - Schipany, Katharina
AU  - Schipany K
FAU - Mikula, Mario
AU  - Mikula M
FAU - Brandau, Oliver
AU  - Brandau O
FAU - Hengstschlager, Markus
AU  - Hengstschlager M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
SB  - IM
MH  - Amniotic Fluid/*cytology/metabolism
MH  - Animals
MH  - Cell Line, Tumor
MH  - Cell Transformation, Neoplastic/*genetics/metabolism
MH  - Disease Models, Animal
MH  - Humans
MH  - Mice
MH  - Neoplastic Stem Cells/*cytology/metabolism
MH  - Stem Cells/*cytology/metabolism
PMC - PMC3248217
EDAT- 2011/09/20 06:00
MHDA- 2012/05/02 06:00
CRDT- 2011/09/20 06:00
PHST- 2011/09/20 06:00 [entrez]
PHST- 2011/09/20 06:00 [pubmed]
PHST- 2012/05/02 06:00 [medline]
AID - 328 [pii]
AID - 10.18632/oncotarget.328 [doi]
PST - ppublish
SO  - Oncotarget. 2011 Sep;2(9):705-12. doi: 10.18632/oncotarget.328.


PMID- 21925409
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20110919
IS  - 1521-6896 (Print)
IS  - 1521-6896 (Linking)
VI  - 25
IP  - 3
DP  - 2011 Sep
TI  - Advance directives, perioperative care and end-of-life planning.
PG  - 451-60
LID - 10.1016/j.bpa.2011.07.005 [doi]
AB  - It is ethically and legally important, when providing care to our patients, to
      respect their autonomy and dignity, to act in their best interests and avoid
      doing harm. Advance care planning is essential to achieving this by giving
      patients the opportunity to tell us what they would want us to do if they became 
      seriously unwell and could no longer communicate their wishes. Whereas earlier
      attempts at advance care planning focussed on the completion of forms, the more
      recent, successful focus has been on the patient-centred discussion, involving
      family, appointment of substitute decision makers and identification of what the 
      patient would see as an acceptable outcome from any proposed treatment. Advance
      care planning is successful in caring for the elderly, including in the
      perioperative setting. There is an increasing focus on improving end-of-life
      care, including the prevention of suffering, making earlier and wiser end-of-life
      decisions about the appropriateness of treatment and improving communication with
      patients and families. New awareness of the poor outcomes from cardiopulmonary
      resuscitation (CPR) is catalysing reassessment of the appropriateness of this
      intervention.
CI  - 2011 Elsevier Ltd. All rights reserved.
FAU - Silvester, William
AU  - Silvester W
AD  - Austin Hospital, Burgundy St., Heidelberg 3084, Melbourne, Australia.
      William.Silvester@austin.org.au
FAU - Detering, Karen
AU  - Detering K
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Best Pract Res Clin Anaesthesiol
JT  - Best practice & research. Clinical anaesthesiology
JID - 101121446
SB  - IM
MH  - Advance Care Planning
MH  - *Advance Directives
MH  - Cardiopulmonary Resuscitation
MH  - Decision Making
MH  - Ethics, Medical
MH  - Humans
MH  - *Perioperative Care
MH  - *Terminal Care
EDAT- 2011/09/20 06:00
MHDA- 2011/11/09 06:00
CRDT- 2011/09/20 06:00
PHST- 2011/06/24 00:00 [received]
PHST- 2011/07/12 00:00 [accepted]
PHST- 2011/09/20 06:00 [entrez]
PHST- 2011/09/20 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - S1521-6896(11)00058-9 [pii]
AID - 10.1016/j.bpa.2011.07.005 [doi]
PST - ppublish
SO  - Best Pract Res Clin Anaesthesiol. 2011 Sep;25(3):451-60. doi:
      10.1016/j.bpa.2011.07.005.


PMID- 21925144
OWN - NLM
STAT- MEDLINE
DCOM- 20111206
LR  - 20220330
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 413
IP  - 4
DP  - 2011 Oct 7
TI  - Differentiation of human umbilical cord mesenchymal stem cells into dermal
      fibroblasts in vitro.
PG  - 561-5
LID - 10.1016/j.bbrc.2011.09.001 [doi]
AB  - Tissue-derived umbilical cord mesenchymal stem cells (UCMSCs) can be readily
      obtained, avoid ethical or moral constraints, and show excellent pluripotency and
      proliferation potential. UCMSCs are considered to be a promising source of stem
      cells in regenerative medicine. In this study, we collected newborn umbilical
      cord tissue under sterile conditions and isolated UCMSCs through a tissue
      attachment method. UCMSC cell surface markers were examined using flow cytometry.
      On the third passage, UCMSCs were induced to differentiate into dermal
      fibroblasts in conditioned induction media. The induction results were detected
      using immunofluorescence with a fibroblast-specific monoclonal antibody and real 
      time PCR for type I and type III collagen. UCMSCs exhibited a fibroblast-like
      morphology and reached 90% confluency 14 to 18 days after primary culture.
      Cultured UCMSCs showed strong positive staining for CD73, CD29, CD44, CD105, and 
      HLA-I, but not CD34, CD45, CD31, or HLA-DR. After differentiation, immunostaining
      for collagen type I, type III, fibroblast-specific protein, vimentin, and desmin 
      were all strongly positive in induced cells, and staining was weak or negative in
      non-induced cells; total transcript production of collagen type I and collagen
      type III mRNA was higher in induced cells than in non-induced cells. These
      results demonstrate that UCMSCs can be induced to differentiate into fibroblasts 
      with conditioned induction media and, in turn, could be used as seed cells for
      tissue-engineered dermis.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Han, Yanfu
AU  - Han Y
AD  - Department of Burn and Plastic Surgery, Burns Institute, First Hospital
      Affiliated to General Hospital of PLA, Beijing, China.
FAU - Chai, Jiake
AU  - Chai J
FAU - Sun, Tianjun
AU  - Sun T
FAU - Li, Dongjie
AU  - Li D
FAU - Tao, Ran
AU  - Tao R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110908
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Antigens, CD)
RN  - 0 (Culture Media, Conditioned)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Antigens, CD/analysis
MH  - *Cell Differentiation
MH  - Cell Separation
MH  - Culture Media, Conditioned/pharmacology
MH  - Dermis/chemistry/*cytology
MH  - Fibroblasts/chemistry/*cytology
MH  - HLA-DR Antigens/analysis
MH  - Humans
MH  - Mesenchymal Stem Cells/chemistry/*cytology/drug effects
MH  - Tissue Engineering/*methods
MH  - Umbilical Cord/chemistry/*cytology/drug effects
EDAT- 2011/09/20 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/09/20 06:00
PHST- 2011/08/21 00:00 [received]
PHST- 2011/09/01 00:00 [accepted]
PHST- 2011/09/20 06:00 [entrez]
PHST- 2011/09/20 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0006-291X(11)01572-5 [pii]
AID - 10.1016/j.bbrc.2011.09.001 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2011 Oct 7;413(4):561-5. doi:
      10.1016/j.bbrc.2011.09.001. Epub 2011 Sep 8.


PMID- 21924121
OWN - NLM
STAT- MEDLINE
DCOM- 20121211
LR  - 20131121
IS  - 0040-5957 (Print)
IS  - 0040-5957 (Linking)
VI  - 66
IP  - 3
DP  - 2011 May-Jun
TI  - [Disulfiram and addiction: reminders and new perspectives of use].
PG  - 273-80
AB  - Disulfiram is a relatively old molecule, which today remains marginal in the
      treatment of alcoholics diseases. Using this type of treatment is the subject of 
      ethical debate. The prescription of this therapeutic requires clinical and
      biological rigorous evaluations before treatment. Its main action in treatment of
      alcoholism is related to the restraint of acetaldehyde dehydrogenase action
      causing the antabuse reaction. Prescription of disulfiram, supported by
      specialized programs of compartmental integrated care, brings significant benefit
      for alcoholic patients. Recently, following the discovery of its action on
      dopamine metabolism, disulfiram has been a renewed interest in the treatment of
      addictions to cocaine and pathological gambling. Although current data are
      insufficient to generalize its use in routine practice, they constitute a line of
      research interest for the future.
CI  - (c) 2011 Societe Francaise de Pharmacologie et de Therapeutique.
FAU - Charpeaud, Thomas
AU  - Charpeaud T
AD  - Service de Psychiatrie de l'Adulte B, CHU de Clermont-Ferrand, Clermont-Ferrand, 
      France. tcharpeaud@chu-clermonferrand.fr
FAU - Geneste, Julie
AU  - Geneste J
FAU - Schmidt, Jeannot
AU  - Schmidt J
FAU - Llorca, Pierre-Michel
AU  - Llorca PM
FAU - Brousse, Georges
AU  - Brousse G
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Le disulfirame (Esperal((R))) dans le traitement des addictions : rappels et
      nouvelles perspectives d'utilisation.
DEP - 20110809
PL  - France
TA  - Therapie
JT  - Therapie
JID - 0420544
RN  - 0 (Alcohol Deterrents)
RN  - 0 (Central Nervous System Depressants)
RN  - 0 (Drug Implants)
RN  - 3K9958V90M (Ethanol)
RN  - TR3MLJ1UAI (Disulfiram)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Alcohol Deterrents/administration &
      dosage/chemistry/pharmacokinetics/pharmacology/*therapeutic use
MH  - Alcoholism/*drug therapy
MH  - Central Nervous System Depressants/pharmacokinetics
MH  - Disulfiram/administration &
      dosage/chemistry/pharmacokinetics/pharmacology/*therapeutic use
MH  - Dopamine/metabolism
MH  - Drug Implants
MH  - Ethanol/pharmacokinetics
MH  - Gambling
MH  - Humans
MH  - Substance-Related Disorders/drug therapy
EDAT- 2011/09/20 06:00
MHDA- 2012/12/12 06:00
CRDT- 2011/09/20 06:00
PHST- 2010/12/22 00:00 [received]
PHST- 2011/03/02 00:00 [accepted]
PHST- 2011/09/20 06:00 [entrez]
PHST- 2011/09/20 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - 10.2515/therapie/2011025 [doi]
AID - th111962 [pii]
PST - ppublish
SO  - Therapie. 2011 May-Jun;66(3):273-80. doi: 10.2515/therapie/2011025. Epub 2011 Aug
      9.


PMID- 21924058
OWN - NLM
STAT- MEDLINE
DCOM- 20120329
LR  - 20160607
IS  - 0578-1310 (Print)
IS  - 0578-1310 (Linking)
VI  - 49
IP  - 6
DP  - 2011 Jun
TI  - [Treatment of newborns with severe injured brain with transplantation of human
      neural precursor cells].
PG  - 445-9
AB  - OBJECTIVE: To analyze the therapeutic effect of human neural precursor cells
      transplantation in treatment of neonates with severe brain injury. METHOD: The
      transplantation was performed on 6 newborns, one of them was diagnosed as
      extremely severe carbon monoxide poisoning at 5(th) day after birth; one of them 
      was diagnosed as severe hypoglycemia; the others had asphyxia at birth with Apgar
      scores from 1 to 3 and were diagnosed as severe neonatal asphyxia, severe hypoxic
      ischemic encephalopathy according to images, electroencephalogram, biochemical
      examination and clinical manifestation. With the approval of hospital ethics
      committee and informed consent of the family members, the newborns received human
      neural precursor cells transplantation at the 4(th) to 20(th) day after birth.
      With the agreement of a pregnant woman, forebrain cells were obtained from the
      forebrain of her 12-week old fetus after spontaneous abortion. The cells from the
      fetal brain were amplified into human neural precursor cells in vitro and were
      injected into the cerebral ventricle of the patients. RESULT: On the 2(nd) day
      after transplantation, sucking and swallowing reflexes gradually appeared in all 
      the patients, muscular tension was also improved, and convulsion stopped. NBNA
      scoring in 3 of the patients reached normal level on the 28(th) day after birth. 
      The 6 patients were followed up for 12 months. Four patients were normal in
      psychomotor development and scores of each scale reached normal level. Two
      patients have cerebral palsy. CONCLUSION: hNPCs transplantation is safe and
      effective in treatment of severe neonatal brain injury. More clinical trials and 
      further observation are needed.
FAU - Luan, Zuo
AU  - Luan Z
AD  - Department of Pediatrics, Navy General Hospital, Beijing 100048, China.
FAU - Liu, Wei-peng
AU  - Liu WP
FAU - Qu, Su-qing
AU  - Qu SQ
FAU - Qu, Su-qing
AU  - Qu SQ
FAU - Hu, Xiao-hong
AU  - Hu XH
FAU - Wang, Zhao-yan
AU  - Wang ZY
FAU - He, Sheng
AU  - He S
FAU - Liu, Cui-qing
AU  - Liu CQ
FAU - Xiao, Min
AU  - Xiao M
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Er Ke Za Zhi
JT  - Zhonghua er ke za zhi = Chinese journal of pediatrics
JID - 0417427
SB  - IM
MH  - Brain Injuries/*surgery
MH  - Female
MH  - Humans
MH  - Hypoxia-Ischemia, Brain/surgery
MH  - Infant, Newborn
MH  - Male
MH  - Neural Stem Cells/cytology/*transplantation
EDAT- 2011/09/20 06:00
MHDA- 2012/03/30 06:00
CRDT- 2011/09/20 06:00
PHST- 2011/09/20 06:00 [entrez]
PHST- 2011/09/20 06:00 [pubmed]
PHST- 2012/03/30 06:00 [medline]
PST - ppublish
SO  - Zhonghua Er Ke Za Zhi. 2011 Jun;49(6):445-9.


PMID- 21923917
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 2043-9113 (Electronic)
IS  - 2043-9113 (Linking)
VI  - 1
IP  - 1
DP  - 2011 Sep 16
TI  - Biobank resources for future patient care: developments, principles and concepts.
PG  - 24
LID - 10.1186/2043-9113-1-24 [doi]
AB  - The aim of the overview is to give a perspective of global biobank development is
      given in a view of positioning biobanking as a key resource for healthcare to
      identify new potential markers that can be used in patient diagnosis and
      complement the targeted personalized drug treatment. The fast progression of
      biobanks around the world is becoming an important resource for society where the
      patient benefit is in the focus, with a high degree of personal integrity and
      ethical standard. Biobanks are providing patient benefits by large scale
      screening studies, generating large database repositories. It is envisioned by
      all participating stakeholders that the biobank initiatives will become the
      future gateway to discover new frontiers within life science and patient care.
      There is a great importance of biobank establishment globally, as biobanks has
      been identified as a key area for development in order to speed up the discovery 
      and development of new drugs and protein biomarker diagnostics. One of the major 
      objectives in Europe is to establish concerted actions, where biobank networks
      are being developed in order to combine and have the opportunity to share and
      build new science and understanding from complex disease biology. These networks 
      are currently building bridges to facilitate the establishments of best practice 
      and standardizations.
FAU - Vegvari, Akos
AU  - Vegvari A
AD  - Clinical Protein Science & Imaging, Biomedical Center, Dept, of Measurement
      Technology and Industrial Electrical Engineering, Lund University, BMC C13,
      SE-221 84 Lund, Sweden. Gyorgy.Marko-Varga@elmat.lth.se.
FAU - Welinder, Charlotte
AU  - Welinder C
FAU - Lindberg, Henrik
AU  - Lindberg H
FAU - Fehniger, Thomas E
AU  - Fehniger TE
FAU - Marko-Varga, Gyorgy
AU  - Marko-Varga G
LA  - eng
PT  - Journal Article
DEP - 20110916
PL  - England
TA  - J Clin Bioinforma
JT  - Journal of clinical bioinformatics
JID - 101554637
PMC - PMC3197484
EDAT- 2011/09/20 06:00
MHDA- 2011/09/20 06:01
CRDT- 2011/09/20 06:00
PHST- 2011/05/18 00:00 [received]
PHST- 2011/09/16 00:00 [accepted]
PHST- 2011/09/20 06:00 [entrez]
PHST- 2011/09/20 06:00 [pubmed]
PHST- 2011/09/20 06:01 [medline]
AID - 2043-9113-1-24 [pii]
AID - 10.1186/2043-9113-1-24 [doi]
PST - epublish
SO  - J Clin Bioinforma. 2011 Sep 16;1(1):24. doi: 10.1186/2043-9113-1-24.


PMID- 21923885
OWN - NLM
STAT- MEDLINE
DCOM- 20120325
LR  - 20111124
IS  - 1399-3046 (Electronic)
IS  - 1397-3142 (Linking)
VI  - 15
IP  - 8
DP  - 2011 Dec
TI  - Pediatric liver retransplantation from living donors can be considered as a
      therapeutic option for patients with irreversible living donor graft failure.
PG  - 798-803
LID - 10.1111/j.1399-3046.2011.01572.x [doi]
AB  - Liver retransplantation (re-LT) is required in patients with irreversible graft
      failure, but it is a significant issue that remains medically, ethically, and
      economically controversial, especially in living donor liver transplantation
      (LDLT). The aim of this study was to evaluate the outcome, morbidity, mortality, 
      safety and prognostic factors to improve the outcome of pediatric living donor
      liver retransplantation (re-LDLT). Six of 172 children that underwent LDLT
      between January 2001 and March 2010 received a re-LDLT and one received a second 
      re-LDLT. The overall re-LDLT rate was 3.5%. All candidates had re-LDLT after the 
      initial LDLT. The overall actuarial survival of these patients was 83.3% and
      83.3% at one and five yr, respectively. These rates are significantly worse than 
      the rates of pediatric first LDLT. Vascular complications occurred in four
      patients and were successfully treated by interventional radiologic therapy.
      There were no post-operative biliary complications. One case expired because of
      hemophagocytic syndrome after re-LDLT. Although pediatric re-LDLT is medically,
      ethically, and economically controversial, it is a feasible option and should be 
      offered to children with irreversible graft failure. Further investigations,
      including multicenter studies, are therefore essential to identify any prognostic
      factors that may improve the present poor outcome after re-LDLT.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Urahashi, T
AU  - Urahashi T
AD  - Department of Transplant Surgery, Jichi Medical University, Shimotsuke-shi,
      Tochigi, Japan. turahashi@jichi.ac.jp
FAU - Mizuta, K
AU  - Mizuta K
FAU - Sanada, Y
AU  - Sanada Y
FAU - Wakiya, T
AU  - Wakiya T
FAU - Umehara, M
AU  - Umehara M
FAU - Hishikawa, S
AU  - Hishikawa S
FAU - Hyodo, M
AU  - Hyodo M
FAU - Sakuma, Y
AU  - Sakuma Y
FAU - Fujiwara, T
AU  - Fujiwara T
FAU - Yasuda, Y
AU  - Yasuda Y
FAU - Kawarasaki, H
AU  - Kawarasaki H
LA  - eng
PT  - Journal Article
DEP - 20110916
PL  - Denmark
TA  - Pediatr Transplant
JT  - Pediatric transplantation
JID - 9802574
SB  - IM
MH  - Child, Preschool
MH  - Female
MH  - Graft Survival
MH  - Humans
MH  - Infant
MH  - *Liver Transplantation/methods
MH  - *Living Donors
MH  - Male
MH  - Postoperative Complications/surgery
MH  - Primary Graft Dysfunction/*surgery
MH  - Reoperation/methods
EDAT- 2011/09/20 06:00
MHDA- 2012/03/27 06:00
CRDT- 2011/09/20 06:00
PHST- 2011/09/20 06:00 [entrez]
PHST- 2011/09/20 06:00 [pubmed]
PHST- 2012/03/27 06:00 [medline]
AID - 10.1111/j.1399-3046.2011.01572.x [doi]
PST - ppublish
SO  - Pediatr Transplant. 2011 Dec;15(8):798-803. doi:
      10.1111/j.1399-3046.2011.01572.x. Epub 2011 Sep 16.


PMID- 21817860
OWN - NLM
STAT- MEDLINE
DCOM- 20111209
LR  - 20220316
IS  - 1559-713X (Electronic)
IS  - 1559-2332 (Linking)
VI  - 6 Suppl
DP  - 2011 Aug
TI  - The study of factors affecting human and systems performance in healthcare using 
      simulation.
PG  - S24-9
LID - 10.1097/SIH.0b013e318229f5c8 [doi]
AB  - A large body of research using simulation in healthcare has focused on simulation
      itself as an object of research. However, simulation can also be used in research
      on human or system performance. It can be used to investigate the effects of
      performance shaping factors that would otherwise be difficult to study in the
      actual clinical setting due to practical constraints or ethical concerns. In this
      monograph, we illustrate various ways in which simulation has been used to study 
      performance shaping factors. We also discuss possible directions for future
      research as well as methodological considerations for researchers engaging in
      this approach to study performance shaping factors.
FAU - LeBlanc, Vicki R
AU  - LeBlanc VR
AD  - Wilson Centre, University of Toronto, 200 Elizabeth Street, Toronto, ON, Canada. 
      vicki.leblanc@utoronto.ca
FAU - Manser, Tanja
AU  - Manser T
FAU - Weinger, Matthew B
AU  - Weinger MB
FAU - Musson, David
AU  - Musson D
FAU - Kutzin, Jared
AU  - Kutzin J
FAU - Howard, Steven K
AU  - Howard SK
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Simul Healthc
JT  - Simulation in healthcare : journal of the Society for Simulation in Healthcare
JID - 101264408
SB  - IM
MH  - *Clinical Competence
MH  - *Computer Simulation
MH  - Health Personnel
MH  - Humans
MH  - *Quality Indicators, Health Care
MH  - Systems Integration
EDAT- 2011/09/20 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/08/06 06:00
PHST- 2011/08/06 06:00 [entrez]
PHST- 2011/09/20 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 10.1097/SIH.0b013e318229f5c8 [doi]
AID - 01266021-201108001-00005 [pii]
PST - ppublish
SO  - Simul Healthc. 2011 Aug;6 Suppl:S24-9. doi: 10.1097/SIH.0b013e318229f5c8.


PMID- 21922218
OWN - NLM
STAT- MEDLINE
DCOM- 20120206
LR  - 20211020
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 23
IP  - 3
DP  - 2011 Sep
TI  - The Core Competencies: a Roman Catholic critique.
PG  - 147-69
LID - 10.1007/s10730-011-9169-2 [doi]
AB  - This article critically examines, from the perspective of a Roman Catholic
      Healthcare ethicist, the second edition of the Core Competencies for Healthcare
      Ethics Consultation report recently published by the American Society for
      Humanities and Bioethics. The question is posed: can the competencies identified 
      in the report serve as the core competencies for Roman Catholic ethical
      consultants and consultation services? I answer in the negative. This
      incongruence stems from divergent concepts of what it means to do ethics
      consultation, a divergence that is rooted in each perspective's very different
      visions of autonomy. Furthermore, because of the constitutive elements of
      Catholic ethics consultation, such as the Ethical and Religious Directives for
      Health Care Services, the tradition needed to apply those directives, and the
      Catholic facility's membership in the institutional Church, the competencies
      needed for its practice differ in kind from those identified by the report. While
      there are many practical points of convergence, the competencies identified by
      the report should not be adopted uncritically by Catholic healthcare institutions
      as core competencies for ethical consultation services.
FAU - Bedford, Elliott Louis
AU  - Bedford EL
AD  - Albert Gnaegi Center for Health Care Ethics, Saint Louis University, Mo, USA.
      ebedford@slu.edu
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - *Catholicism
MH  - *Credentialing
MH  - Ethicists/*standards
MH  - *Ethics, Clinical
MH  - *Guidelines as Topic
MH  - Hospitals, Religious/ethics
MH  - Humans
MH  - Personal Autonomy
MH  - *Professional Competence
MH  - *Religion and Medicine
MH  - United States
EDAT- 2011/09/17 06:00
MHDA- 2012/02/07 06:00
CRDT- 2011/09/17 06:00
PHST- 2011/09/17 06:00 [entrez]
PHST- 2011/09/17 06:00 [pubmed]
PHST- 2012/02/07 06:00 [medline]
AID - 10.1007/s10730-011-9169-2 [doi]
PST - ppublish
SO  - HEC Forum. 2011 Sep;23(3):147-69. doi: 10.1007/s10730-011-9169-2.


PMID- 21921746
OWN - NLM
STAT- MEDLINE
DCOM- 20111109
LR  - 20210106
IS  - 1529-4242 (Electronic)
IS  - 0032-1052 (Linking)
VI  - 128
IP  - 4
DP  - 2011 Oct
TI  - The bioethics of separating conjoined twins in plastic surgery.
PG  - 328e-334e
LID - 10.1097/PRS.0b013e3182268c54 [doi]
AB  - The incidence of craniopagus twins approximates four to six per 10 million
      births. Although rare, surgical separation of conjoined twins poses significant
      technical and ethical challenges. The present report uses the case of craniopagus
      twins AD and TD to examine the bioethical issues faced by a multidisciplinary
      medical team in planning the separation of craniopagus twins. AD and TD are
      craniopagus twins conjoined at the head. TD's head is conjoined to the back of
      AD's head. Neurologically, AD has the dominant cerebral circulation. TD has two
      normal kidneys, whereas AD has none. AD depends on TD's renal function and, on
      separation, will require either a kidney transplant or lifelong dialysis. This
      case report reviews one approach to analyzing and solving complex ethical
      dilemmas in pediatric plastic surgery. The principles reviewed are (1) autonomy
      and informed consent, focusing especially on the role of children in the informed
      consent process; (2) beneficence and nonmaleficence, two intricately intertwined 
      principles because separation could potentially cause irreversible harm to one
      twin while improving the quality of life for the other (as separation is not a
      life-saving procedure, is it ethical to perform a procedure with unknown surgical
      risk to improve children's quality of life?); and (3) justice (is it fair to
      allocate excessive medical resources for the twins' separation?). The present
      report explores the ethics behind such decisions with respect to the separation
      of conjoined twins.
FAU - Lee, Michelle
AU  - Lee M
AD  - Cleveland, Ohio From the Department of Plastic and Reconstructive Surgery,
      Rainbow Babies and Children's Hospital, University Hospitals Case Medical Center,
      Case Western Reserve University.
FAU - Gosain, Arun K
AU  - Gosain AK
FAU - Becker, Devra
AU  - Becker D
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Plast Reconstr Surg
JT  - Plastic and reconstructive surgery
JID - 1306050
SB  - IM
MH  - *Bioethical Issues
MH  - Child, Preschool
MH  - Decision Making
MH  - Elective Surgical Procedures/adverse effects/methods
MH  - Female
MH  - Head/*surgery
MH  - Humans
MH  - Parental Consent
MH  - Prognosis
MH  - Reconstructive Surgical Procedures/methods
MH  - Risk Assessment
MH  - Surgery, Plastic/methods
MH  - Treatment Outcome
MH  - Twins, Conjoined/*surgery
EDAT- 2011/09/17 06:00
MHDA- 2011/11/10 06:00
CRDT- 2011/09/17 06:00
PHST- 2011/09/17 06:00 [entrez]
PHST- 2011/09/17 06:00 [pubmed]
PHST- 2011/11/10 06:00 [medline]
AID - 10.1097/PRS.0b013e3182268c54 [doi]
AID - 00006534-201110000-00031 [pii]
PST - ppublish
SO  - Plast Reconstr Surg. 2011 Oct;128(4):328e-334e. doi:
      10.1097/PRS.0b013e3182268c54.


PMID- 21921735
OWN - NLM
STAT- MEDLINE
DCOM- 20111109
LR  - 20220318
IS  - 1529-4242 (Electronic)
IS  - 0032-1052 (Linking)
VI  - 128
IP  - 4
DP  - 2011 Oct
TI  - Harmonic scalpel versus electrocautery in breast reduction surgery: a randomized 
      controlled trial.
PG  - 243e-249e
LID - 10.1097/PRS.0b013e318221da3e [doi]
AB  - BACKGROUND: The authors hypothesized that the Harmonic Scalpel (Ethicon
      Endo-Surgery, Cincinnati, Ohio) might outperform electrocautery in bilateral
      breast reduction surgery, possibly resulting in (1) shorter operative times, (2) 
      lower postoperative fluid drainage rates, and (3) reduced postoperative pain
      scores. METHODS: Thirty-one patients were evaluated in a matched-pair design,
      with random (blinded) assignment of one side to the Harmonic Scalpel, with the
      other side defaulting to electrocautery. Main outcome measures were: (1)
      resection/hemostasis time, (2) drainage volume, and (3) postoperative pain. The
      authors also compared the learning curves, operative time versus specimen
      weights, complications, and costs for the devices. RESULTS: There was a
      statistically significant (but not clinically significant) difference between the
      median times for the Harmonic Scalpel (33 minutes) and electrocautery (31
      minutes) (p=0.02). There was no statistical difference in drainage scores, and
      pain scores were equivalent. The analysis of specimen weight versus
      resection/hemostasis time showed no correlation. There were more complications on
      the breasts reduced with the Harmonic device, but due to the small sample size,
      the complication results were not statistically significant. Start-up costs for
      the devices were comparable, but the per-procedure cost for the Harmonic device
      was considerably higher. CONCLUSIONS: The Harmonic Scalpel is roughly equivalent 
      to electrocautery in breast reduction surgery in terms of resection/hemostasis
      time, serous drainage, and postoperative pain. Though the Harmonic device may be 
      excellent for other surgical procedures, its high cost suggests that surgeons and
      institutions can confidently forgo its use in breast reduction surgery. CLINICAL 
      QUESTION/LEVEL OF EVIDENCE: Therapeutic, II.
FAU - Burdette, Todd E
AU  - Burdette TE
AD  - Lebanon, N.H. From the Division of Plastic and Reconstructive Surgery and the
      Leadership Preventive Medicine Residency Program, Dartmouth-Hitchcock Medical
      Center.
FAU - Kerrigan, Carolyn L
AU  - Kerrigan CL
FAU - Homa, Karen A
AU  - Homa KA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Plast Reconstr Surg
JT  - Plastic and reconstructive surgery
JID - 1306050
SB  - IM
CIN - Plast Reconstr Surg. 2011 Oct;128(4):250e-251e. PMID: 21921736
EIN - Plast Reconstr Surg. 2011 Dec;128(6):1317. Homa, Karen A [corrected to Homa,
      Karen]
MH  - Adult
MH  - Electrocoagulation/adverse effects/*methods
MH  - Esthetics
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Mammaplasty/instrumentation/*methods
MH  - Middle Aged
MH  - Postoperative Complications/physiopathology
MH  - Risk Assessment
MH  - Single-Blind Method
MH  - Surgical Instruments
MH  - Time Factors
MH  - Treatment Outcome
MH  - Ultrasonic Therapy/adverse effects/*instrumentation
MH  - Young Adult
EDAT- 2011/09/17 06:00
MHDA- 2011/11/10 06:00
CRDT- 2011/09/17 06:00
PHST- 2011/09/17 06:00 [entrez]
PHST- 2011/09/17 06:00 [pubmed]
PHST- 2011/11/10 06:00 [medline]
AID - 10.1097/PRS.0b013e318221da3e [doi]
AID - 00006534-201110000-00004 [pii]
PST - ppublish
SO  - Plast Reconstr Surg. 2011 Oct;128(4):243e-249e. doi:
      10.1097/PRS.0b013e318221da3e.


PMID- 21921090
OWN - NLM
STAT- MEDLINE
DCOM- 20120227
LR  - 20111026
IS  - 2044-5423 (Electronic)
IS  - 2044-5415 (Linking)
VI  - 20
IP  - 11
DP  - 2011 Nov
TI  - An ethicist's journey as a patient: are we sliding down the slippery slope to
      sloppy healthcare?
PG  - 983-5
LID - 10.1136/bmjqs-2011-000235 [doi]
AB  - People who are sick are often the most vulnerable in society. They frequently
      rely on caring and competent healthcare professionals and should and do have
      expectations of a safe and caring environment. In a recent unexpected adventure
      through the healthcare system, the organisation, professionalism, caring and
      compassion associated with healthcare provision were in very short supply. A lack
      of basic dignity and humanity were among the most concerning deficits. Any form
      of dehumanisation of the national health service that leads to unsafe,
      undignified and degrading treatment not only infringes patients' and clients'
      human rights but should not be acceptable or excused as a by-product of economic 
      pressures.
FAU - McCullough, Melissa
AU  - McCullough M
AD  - Centre for Medical Education, Queen's University Belfast, 97 Lisburn Road,
      Belfast, Northern Ireland. m.mccullough@qub.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20110915
PL  - England
TA  - BMJ Qual Saf
JT  - BMJ quality & safety
JID - 101546984
CIN - BMJ Qual Saf. 2011 Nov;20(11):911-3. PMID: 21964611
MH  - *Dehumanization
MH  - Delivery of Health Care/ethics/trends
MH  - Humans
MH  - Patients/*psychology
MH  - *Quality of Health Care
EDAT- 2011/09/17 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/09/17 06:00
PHST- 2011/09/17 06:00 [entrez]
PHST- 2011/09/17 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - bmjqs-2011-000235 [pii]
AID - 10.1136/bmjqs-2011-000235 [doi]
PST - ppublish
SO  - BMJ Qual Saf. 2011 Nov;20(11):983-5. doi: 10.1136/bmjqs-2011-000235. Epub 2011
      Sep 15.


PMID- 21920987
OWN - NLM
STAT- MEDLINE
DCOM- 20121004
LR  - 20220408
IS  - 1477-030X (Electronic)
IS  - 0269-2163 (Linking)
VI  - 26
IP  - 5
DP  - 2012 Jul
TI  - Development of a nationwide consensus syllabus of palliative medicine for
      undergraduate medical education in Japan: a modified Delphi method.
PG  - 744-52
LID - 10.1177/0269216311410346 [doi]
AB  - BACKGROUND: There is currently no consensus syllabus of palliative medicine for
      undergraduate medical education in Japan, although the Cancer Control Act
      proposed in 2007 covers the dissemination of palliative care. AIM: To develop a
      nationwide consensus syllabus of palliative medicine for undergraduate medical
      education in Japan using a modified Delphi method. DESIGN: We adopted the
      following three-step method: (1) a workshop to produce the draft syllabus; (2) a 
      survey-based provisional syllabus; (3) Delphi rounds and a panel meeting
      (modified Delphi method) to produce the working syllabus. Educators in charge of 
      palliative medicine from 63% of the medical schools in Japan collaborated to
      develop a survey-based provisional syllabus before the Delphi rounds. A panel of 
      32 people was then formed for the modified Delphi rounds comprising 28 educators 
      and experts in palliative medicine, one cancer survivor, one bereaved family
      member, and two medical students. RESULTS: The final consensus syllabus consists 
      of 115 learning objectives across seven sections as follows: basic principles;
      disease process and comprehensive assessment; symptom management; psychosocial
      care; cultural, religious, and spiritual issues; ethical issues; and legal
      frameworks. Learning objectives were categorized as essential or desirable
      (essential: 66; desirable: 49). CONCLUSIONS: A consensus syllabus of palliative
      medicine for undergraduate medical education was developed using a clear and
      innovative methodology. The final consensus syllabus will be made available for
      further dissemination of palliative care education throughout the country.
FAU - Kizawa, Yoshiyuki
AU  - Kizawa Y
AD  - Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan.
      ykizawa@md.tsukuba.ac.jp
FAU - Tsuneto, Satoru
AU  - Tsuneto S
FAU - Tamba, Kaichiro
AU  - Tamba K
FAU - Takamiya, Yusuke
AU  - Takamiya Y
FAU - Morita, Tatsuya
AU  - Morita T
FAU - Bito, Seiji
AU  - Bito S
FAU - Otaki, Junji
AU  - Otaki J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110915
PL  - England
TA  - Palliat Med
JT  - Palliative medicine
JID - 8704926
SB  - IM
MH  - Curriculum/*standards
MH  - *Delphi Technique
MH  - Education, Medical, Undergraduate/methods/*standards
MH  - Humans
MH  - Japan
MH  - Palliative Care/*standards
EDAT- 2011/09/17 06:00
MHDA- 2012/10/05 06:00
CRDT- 2011/09/17 06:00
PHST- 2011/09/17 06:00 [entrez]
PHST- 2011/09/17 06:00 [pubmed]
PHST- 2012/10/05 06:00 [medline]
AID - 0269216311410346 [pii]
AID - 10.1177/0269216311410346 [doi]
PST - ppublish
SO  - Palliat Med. 2012 Jul;26(5):744-52. doi: 10.1177/0269216311410346. Epub 2011 Sep 
      15.


PMID- 21920485
OWN - NLM
STAT- MEDLINE
DCOM- 20120320
LR  - 20220331
IS  - 1873-2763 (Electronic)
IS  - 1873-2763 (Linking)
VI  - 49
IP  - 6
DP  - 2011 Dec
TI  - Lathyrism-induced alterations in collagen cross-links influence the mechanical
      properties of bone material without affecting the mineral.
PG  - 1232-41
LID - 10.1016/j.bone.2011.08.027 [doi]
AB  - In the present study a rat animal model of lathyrism was employed to decipher
      whether anatomically confined alterations in collagen cross-links are sufficient 
      to influence the mechanical properties of whole bone. Animal experiments were
      performed under an ethics committee approved protocol. Sixty-four female (47 day 
      old) rats of equivalent weights were divided into four groups (16 per group):
      Controls were fed a semi-synthetic diet containing 0.6% calcium and 0.6%
      phosphorus for 2 or 4 weeks and beta-APN treated animals were fed additionally
      with beta-aminopropionitrile (0.1% dry weight). At the end of this period the
      rats in the four groups were sacrificed, and L2-L6 vertebra were collected.
      Collagen cross-links were determined by both biochemical and spectroscopic
      (Fourier transform infrared imaging (FTIRI)) analyses. Mineral content and
      distribution (BMDD) were determined by quantitative backscattered electron
      imaging (qBEI), and mineral maturity/crystallinity by FTIRI techniques. Micro-CT 
      was used to describe the architectural properties. Mechanical performance of
      whole bone as well as of bone matrix material was tested by vertebral compression
      tests and by nano-indentation, respectively. The data of the present study
      indicate that beta-APN treatment changed whole vertebra properties compared to
      non-treated rats, including collagen cross-links pattern, trabecular bone volume 
      to tissue ratio and trabecular thickness, which were all decreased (p<0.05).
      Further, compression tests revealed a significant negative impact of beta-APN
      treatment on maximal force to failure and energy to failure, while stiffness was 
      not influenced. Bone mineral density distribution (BMDD) was not altered either. 
      At the material level, beta-APN treated rats exhibited increased Pyd/Divalent
      cross-link ratios in areas confined to a newly formed bone. Moreover,
      nano-indentation experiments showed that the E-modulus and hardness were reduced 
      only in newly formed bone areas under the influence of beta-APN, despite a
      similar mineral content. In conclusion the results emphasize the pivotal role of 
      collagen cross-links in the determination of bone quality and mechanical
      integrity. However, in this rat animal model of lathyrism, the coupled
      alterations of tissue structural properties make it difficult to weigh the
      contribution of the anatomically confined material changes to the overall
      mechanical performance of whole bone. Interestingly, the collagen cross-link
      ratio in bone forming areas had the same profile as seen in actively bone forming
      trabecular surfaces in human iliac crest biopsies of osteoporotic patients.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Paschalis, E P
AU  - Paschalis EP
AD  - Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA 
      Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Vienna,
      Austria. eleftherios.paschalis@osteologie.at
FAU - Tatakis, D N
AU  - Tatakis DN
FAU - Robins, S
AU  - Robins S
FAU - Fratzl, P
AU  - Fratzl P
FAU - Manjubala, I
AU  - Manjubala I
FAU - Zoehrer, R
AU  - Zoehrer R
FAU - Gamsjaeger, S
AU  - Gamsjaeger S
FAU - Buchinger, B
AU  - Buchinger B
FAU - Roschger, A
AU  - Roschger A
FAU - Phipps, R
AU  - Phipps R
FAU - Boskey, A L
AU  - Boskey AL
FAU - Dall'Ara, E
AU  - Dall'Ara E
FAU - Varga, P
AU  - Varga P
FAU - Zysset, P
AU  - Zysset P
FAU - Klaushofer, K
AU  - Klaushofer K
FAU - Roschger, P
AU  - Roschger P
LA  - eng
GR  - R01 AR041325/AR/NIAMS NIH HHS/United States
GR  - R01 AR046505/AR/NIAMS NIH HHS/United States
GR  - AR046505/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110902
PL  - United States
TA  - Bone
JT  - Bone
JID - 8504048
RN  - 0 (Cross-Linking Reagents)
RN  - 151-18-8 (Aminopropionitrile)
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Aminopropionitrile
MH  - Analysis of Variance
MH  - Animals
MH  - Biomechanical Phenomena/physiology
MH  - Bone Density/*physiology
MH  - Collagen/*metabolism
MH  - Cross-Linking Reagents/*metabolism
MH  - Female
MH  - Humans
MH  - Lathyrism/*metabolism/*physiopathology
MH  - Rats
MH  - Spine/diagnostic imaging/*physiopathology
MH  - X-Ray Microtomography
PMC - PMC3229977
EDAT- 2011/09/17 06:00
MHDA- 2012/03/21 06:00
CRDT- 2011/09/17 06:00
PHST- 2011/05/27 00:00 [received]
PHST- 2011/08/24 00:00 [revised]
PHST- 2011/08/26 00:00 [accepted]
PHST- 2011/09/17 06:00 [entrez]
PHST- 2011/09/17 06:00 [pubmed]
PHST- 2012/03/21 06:00 [medline]
AID - S8756-3282(11)01195-1 [pii]
AID - 10.1016/j.bone.2011.08.027 [doi]
PST - ppublish
SO  - Bone. 2011 Dec;49(6):1232-41. doi: 10.1016/j.bone.2011.08.027. Epub 2011 Sep 2.


PMID- 21920243
OWN - NLM
STAT- MEDLINE
DCOM- 20111123
LR  - 20180717
IS  - 1097-6787 (Electronic)
IS  - 0190-9622 (Linking)
VI  - 65
IP  - 4
DP  - 2011 Oct
TI  - The impaired physician reporting dilemma: legal, moral, and ethical
      considerations for the practicing dermatologist.
PG  - 833-835
LID - S0190-9622(11)00696-7 [pii]
LID - 10.1016/j.jaad.2011.06.018 [doi]
FAU - Grant-Kels, Jane M
AU  - Grant-Kels JM
AD  - Department of Dermatology, Professor and Chair, Director of Dermatopathology,
      Cutaneous Oncology Center and Dermatology Residency, University of Connecticut
      Health Center, Farmington, Connecticut. Electronic address: grant@uchc.edu.
FAU - Kels, Barry D
AU  - Kels BD
AD  - Executive Director of Risk Management and Associate Professor of Surgery,
      University of Connecticut Health Center, Farmington, Connecticut.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Acad Dermatol
JT  - Journal of the American Academy of Dermatology
JID - 7907132
SB  - IM
MH  - Dermatology/*standards
MH  - Duty to Warn/*ethics
MH  - Humans
MH  - Morals
MH  - Physician Impairment/*legislation & jurisprudence
EDAT- 2011/09/17 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/09/17 06:00
PHST- 2011/04/22 00:00 [received]
PHST- 2011/06/09 00:00 [revised]
PHST- 2011/06/10 00:00 [accepted]
PHST- 2011/09/17 06:00 [entrez]
PHST- 2011/09/17 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0190-9622(11)00696-7 [pii]
AID - 10.1016/j.jaad.2011.06.018 [doi]
PST - ppublish
SO  - J Am Acad Dermatol. 2011 Oct;65(4):833-835. doi: 10.1016/j.jaad.2011.06.018.


PMID- 21920211
OWN - NLM
STAT- MEDLINE
DCOM- 20120125
LR  - 20140205
IS  - 1806-907X (Electronic)
IS  - 0034-7094 (Linking)
VI  - 61
IP  - 5
DP  - 2011 Sep-Oct
TI  - Use of a minimally invasive uncalibrated cardiac output monitor in patients
      undergoing cesarean section under spinal anesthesia: report of four cases.
PG  - 610-8, 334-8
LID - 10.1016/S0034-7094(11)70072-1 [doi]
AB  - BACKGROUND AND OBJECTIVES: Hemodynamic changes are observed during cesarean
      section under spinal anesthesia. Non-invasive blood pressure (BP) and heart rate 
      (HR) measurements are performed to diagnose these changes, but they are delayed
      and inaccurate. Other monitors such as filling pressure and cardiac output (CO)
      catheters with external calibration are very invasive or inaccurate. The
      objective of the present study was to report the cardiac output measurements
      obtained with a minimally invasive uncalibrated monitor (LiDCO rapid) in patients
      undergoing cesarean section under spinal anesthesia. CASE REPORT: After approval 
      by the Ethics Commission, four patients agreed to participate in this study. They
      underwent cesarean section under spinal anesthesia while at the same time being
      connected to the LiDCO rapid by a radial artery line. Cardiac output, HR, and BP 
      were recorded at baseline, after spinal anesthesia, after fetal and placental
      extraction, and after the infusion of oxytocin and metaraminol. We observed a
      fall in BP with an increase of HR and CO after spinal anesthesia and oxytocin
      infusion; and an increase in BP with a fall in HR and CO after bolus of the
      vasopressor. CONCLUSIONS: Although this monitor had not been calibrated, it
      showed a tendency for consistent hemodynamic data in obstetric patients and it
      may be used as a therapeutic guide or experimental tool.
CI  - Copyright (c) 2011 Elsevier Editora Ltda. All rights reserved.
FAU - Bliacheriene, Fernando
AU  - Bliacheriene F
AD  - Divisao de Anestesia, Hospital das Clinicas da Faculdade de Medicina da USP, Sao 
      Paulo, Brazil. fernandobli@uol.com.br
FAU - Carmona, Maria Jose Carvalho
AU  - Carmona MJ
FAU - Barretti, Cristina de Freitas Madeira
AU  - Barretti Cde F
FAU - Haddad, Cristiane Maria Federicci
AU  - Haddad CM
FAU - Mouchalwat, Elaine Soubhi
AU  - Mouchalwat ES
FAU - Bortolotto, Maria Rita de Figueiredo Lemos
AU  - Bortolotto MR
FAU - Francisco, Rossana Pulcineli Vieira
AU  - Francisco RP
FAU - Zugaib, Marcelo
AU  - Zugaib M
LA  - eng
LA  - por
LA  - spa
PT  - Case Reports
PT  - Journal Article
PL  - Brazil
TA  - Rev Bras Anestesiol
JT  - Revista brasileira de anestesiologia
JID - 0401316
SB  - IM
MH  - Adult
MH  - *Anesthesia, Obstetrical
MH  - *Anesthesia, Spinal
MH  - *Cardiac Output
MH  - *Cesarean Section
MH  - Female
MH  - Humans
MH  - Monitoring, Intraoperative/*methods
MH  - Pregnancy
EDAT- 2011/09/17 06:00
MHDA- 2012/01/26 06:00
CRDT- 2011/09/17 06:00
PHST- 2010/10/27 00:00 [received]
PHST- 2011/01/31 00:00 [accepted]
PHST- 2011/09/17 06:00 [entrez]
PHST- 2011/09/17 06:00 [pubmed]
PHST- 2012/01/26 06:00 [medline]
AID - S0034-7094(11)70072-1 [pii]
AID - 10.1016/S0034-7094(11)70072-1 [doi]
PST - ppublish
SO  - Rev Bras Anestesiol. 2011 Sep-Oct;61(5):610-8, 334-8. doi:
      10.1016/S0034-7094(11)70072-1.


PMID- 21920155
OWN - NLM
STAT- MEDLINE
DCOM- 20111123
LR  - 20181201
IS  - 0256-9574 (Print)
VI  - 101
IP  - 9
DP  - 2011 Sep 5
TI  - Patient retention gifts in clinical trials - undue inducement or justified
      motivational tools?
PG  - 640-1
AB  - The use of retention gifts in clinical trials has been controversial, with some
      ethicists maintaining that such gifts represent undue inducement to the trial
      participants. A study was conducted at TREAD Research, a site-managed
      organisation based at Tygerberg Hospital, in which 302 participants completed a
      questionnaire that focused on their opinion with regard to such gifts. The
      results suggest that these gifts do not influence patients to participate in a
      clinical trial or influence them to remain on a trial should they wish to
      withdraw. However, they do act as a useful motivational tool and trial
      participants appreciate them.
FAU - Burgess, L J
AU  - Burgess LJ
FAU - Sulzer, N
AU  - Sulzer N
LA  - eng
PT  - Letter
PT  - Comment
DEP - 20110905
PL  - South Africa
TA  - S Afr Med J
JT  - South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
JID - 0404520
SB  - IM
CON - S Afr Med J. 2003 Sep;93(9):677-8. PMID: 14635555
CON - S Afr Med J. 2008 Feb;98(2):93-4. PMID: 18350199
MH  - *Clinical Trials as Topic
MH  - Female
MH  - Humans
MH  - Male
MH  - *Motivation
MH  - Research Subjects/*economics
EDAT- 2011/09/17 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/09/17 06:00
PHST- 2011/05/03 00:00 [received]
PHST- 2011/05/09 00:00 [accepted]
PHST- 2011/09/17 06:00 [entrez]
PHST- 2011/09/17 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PST - epublish
SO  - S Afr Med J. 2011 Sep 5;101(9):640-1.


PMID- 21920071
OWN - NLM
STAT- MEDLINE
DCOM- 20111006
LR  - 20140912
IS  - 0256-9574 (Print)
VI  - 101
IP  - 6
DP  - 2011 May 25
TI  - Breaking bad news - ethical dilemmas for doctors attending to Jewish patients.
PG  - 382-3
FAU - Silbert, Maurice
AU  - Silbert M
AD  - msilbert@mweb.co.za
LA  - eng
PT  - Journal Article
DEP - 20110525
PL  - South Africa
TA  - S Afr Med J
JT  - South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
JID - 0404520
SB  - IM
MH  - Ethics, Medical
MH  - *Judaism
MH  - *Physician-Patient Relations
MH  - South Africa
MH  - *Truth Disclosure
EDAT- 2011/09/17 06:00
MHDA- 2011/10/07 06:00
CRDT- 2011/09/17 06:00
PHST- 2010/08/24 00:00 [received]
PHST- 2010/09/14 00:00 [accepted]
PHST- 2011/09/17 06:00 [entrez]
PHST- 2011/09/17 06:00 [pubmed]
PHST- 2011/10/07 06:00 [medline]
PST - epublish
SO  - S Afr Med J. 2011 May 25;101(6):382-3.


PMID- 21919876
OWN - NLM
STAT- MEDLINE
DCOM- 20120514
LR  - 20190728
IS  - 1873-4286 (Electronic)
IS  - 1381-6128 (Linking)
VI  - 17
IP  - 30
DP  - 2011 Oct
TI  - The future of induced pluripotent stem cells for cardiac therapy and drug
      development.
PG  - 3258-70
AB  - The field of stem cell research was revolutionized with the advent of induced
      pluripotent stem cells. By reprogramming somatic cells to pluripotent stem cells,
      most ethical concerns associated with the use of embryonic stem cells are
      overcome, such that many hopes from the stem cell field now seem a step closer to
      reality. Several methods and cell sources have been described to create induced
      pluripotent stem cells and we discuss their characteristics in terms of
      feasibility and efficiency. From these cells, cardiac progenitors and
      cardiomyocytes can be derived by several protocols and most recent advances as
      well as remaining limitations are being discussed. However, in the short time
      period this technology has been around, evidence emerges that induced pluripotent
      stem cells may be more prone to genetic defects and maintain an epigenetic memory
      and thus may not be entirely the same as embryonic stem cells. Despite the lack
      of a complete fundamental understanding of stem cell biology, and even more of
      ways how to coax them into defined cell types, the technology is quickly adopted 
      by industry. This paper gives an overview of the current applications of induced 
      pluripotent stem cells in cardiovascular drug development and highlights active
      areas of research towards functional repair of the damaged heart. Adult stem
      cells have already been taken to clinical trials and we discuss these results in 
      light of potential and hurdles to be taken to move induced pluripotent stem cells
      to the clinic.
FAU - Thorrez, Lieven
AU  - Thorrez L
AD  - Translational Cardiomyology, Stem Cell Institute Leuven, Katholieke Universiteit 
      Leuven, Herestraat 49, PB814, 3000 Leuven, Belgium.
      lieven.thorrez@med.kuleuven.be
FAU - Sampaolesi, Maurilio
AU  - Sampaolesi M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Curr Pharm Des
JT  - Current pharmaceutical design
JID - 9602487
RN  - 0 (Cardiovascular Agents)
SB  - IM
MH  - Animals
MH  - Cardiovascular Agents/pharmacology
MH  - Cardiovascular Diseases/*therapy
MH  - Cell Differentiation/drug effects/genetics
MH  - *Drug Discovery/methods/trends
MH  - Epigenesis, Genetic
MH  - Heart/physiology
MH  - Humans
MH  - *Induced Pluripotent Stem Cells/cytology/drug effects/transplantation
MH  - Models, Biological
MH  - *Myocytes, Cardiac/cytology/drug effects
MH  - Regeneration
MH  - *Stem Cell Transplantation/methods/trends
EDAT- 2011/09/17 06:00
MHDA- 2012/05/15 06:00
CRDT- 2011/09/17 06:00
PHST- 2011/06/02 00:00 [received]
PHST- 2011/08/11 00:00 [accepted]
PHST- 2011/09/17 06:00 [entrez]
PHST- 2011/09/17 06:00 [pubmed]
PHST- 2012/05/15 06:00 [medline]
AID - BSP/CPD/E-Pub/000611 [pii]
AID - 10.2174/138161211797904154 [doi]
PST - ppublish
SO  - Curr Pharm Des. 2011 Oct;17(30):3258-70. doi: 10.2174/138161211797904154.


PMID- 21919424
OWN - NLM
STAT- MEDLINE
DCOM- 20120105
LR  - 20220210
IS  - 0098-9134 (Print)
IS  - 0098-9134 (Linking)
VI  - 37
IP  - 11
DP  - 2011 Nov
TI  - The role of health care providers in recognizing and reporting elder abuse.
PG  - 28-34; quiz 36-7
LID - 10.3928/00989134-20110831-02 [doi]
AB  - The incidence of abuse cases in older adults is on the rise. Health care
      providers play an important role in recognizing and reporting abuse, the first
      step of which is to prepare themselves with knowledge regarding abuse. This
      consists of knowing the risk factors and signs and symptoms of abuse and how to
      report it. Of equal importance is knowledge of ethical implications, legalities, 
      and ways to prevent elder abuse. Health care providers must take advantage of
      their unique roles to assess for mistreatment as well as to spread knowledge on
      recognizing, reporting, and preventing elder abuse.
CI  - Copyright 2011, SLACK Incorporated.
FAU - Hess, Sheena
AU  - Hess S
AD  - Washburn University School of Nursing, Topeka, KS, USA. Amazing1313@hotmail.com
LA  - eng
PT  - Journal Article
DEP - 20110916
PL  - United States
TA  - J Gerontol Nurs
JT  - Journal of gerontological nursing
JID - 7510258
MH  - Aged
MH  - Education, Continuing
MH  - *Elder Abuse
MH  - *Health Personnel
MH  - Humans
EDAT- 2011/09/17 06:00
MHDA- 2012/01/06 06:00
CRDT- 2011/09/17 06:00
PHST- 2009/12/14 00:00 [received]
PHST- 2011/04/27 00:00 [accepted]
PHST- 2011/09/17 06:00 [entrez]
PHST- 2011/09/17 06:00 [pubmed]
PHST- 2012/01/06 06:00 [medline]
AID - 10.3928/00989134-20111012-50 [doi]
PST - ppublish
SO  - J Gerontol Nurs. 2011 Nov;37(11):28-34; quiz 36-7. doi:
      10.3928/00989134-20111012-50. Epub 2011 Sep 16.


PMID- 21919315
OWN - NLM
STAT- MEDLINE
DCOM- 20111102
LR  - 20110916
IS  - 8756-8160 (Print)
IS  - 8756-8160 (Linking)
VI  - 27
IP  - 1
DP  - 2011 Summer
TI  - Other people's lives: reflections on medicine, ethics, and euthanasia. Part two: 
      medicine versus euthanasia.
PG  - 51-70
FAU - Fenigsen, Richard
AU  - Fenigsen R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Issues Law Med
JT  - Issues in law & medicine
JID - 8511295
SB  - IM
MH  - Euthanasia/*ethics/legislation & jurisprudence
MH  - Hippocratic Oath
MH  - Humans
MH  - Personal Autonomy
MH  - Physician's Role
EDAT- 2011/09/17 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/09/17 06:00
PHST- 2011/09/17 06:00 [entrez]
PHST- 2011/09/17 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
PST - ppublish
SO  - Issues Law Med. 2011 Summer;27(1):51-70.


PMID- 21918944
OWN - NLM
STAT- MEDLINE
DCOM- 20120109
LR  - 20181201
IS  - 1938-3800 (Electronic)
IS  - 0742-3225 (Linking)
VI  - 43
IP  - 8
DP  - 2011 Sep
TI  - Ethical considerations in International Health Electives.
PG  - 592; author reply 592
FAU - Sinha, Rakhi
AU  - Sinha R
LA  - eng
PT  - Letter
PT  - Comment
PL  - United States
TA  - Fam Med
JT  - Family medicine
JID - 8306464
SB  - IM
CON - Fam Med. 2011 Jan;43(1):21-8. PMID: 21213133
MH  - *Career Choice
MH  - *Education, Medical
MH  - *Global Health
MH  - Humans
MH  - *Learning
MH  - Students, Medical/*psychology
EDAT- 2011/09/16 06:00
MHDA- 2012/01/10 06:00
CRDT- 2011/09/16 06:00
PHST- 2011/09/16 06:00 [entrez]
PHST- 2011/09/16 06:00 [pubmed]
PHST- 2012/01/10 06:00 [medline]
PST - ppublish
SO  - Fam Med. 2011 Sep;43(8):592; author reply 592.


PMID- 21918922
OWN - NLM
STAT- MEDLINE
DCOM- 20131126
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 1
DP  - 2013 Mar
TI  - The intervention of robot caregivers and the cultivation of children's capability
      to play.
PG  - 123-37
LID - 10.1007/s11948-011-9309-8 [doi]
AB  - In this article, the authors examine whether and how robot caregivers can
      contribute to the welfare of children with various cognitive and physical
      impairments by expanding recreational opportunities for these children. The
      capabilities approach is used as a basis for informing the relevant discussion.
      Though important in its own right, having the opportunity to play is essential to
      the development of other capabilities central to human flourishing. Drawing from 
      empirical studies, the authors show that the use of various types of robots has
      already helped some children with impairments. Recognizing the potential ethical 
      pitfalls of robot caregiver intervention, however, the authors examine these
      concerns and conclude that an appropriately designed robot caregiver has the
      potential to contribute positively to the development of the capability to play
      while also enhancing the ability of human caregivers to understand and interact
      with care recipients.
FAU - Pearson, Yvette
AU  - Pearson Y
AD  - Department of Philosophy and Religious Studies, Old Dominion University, Norfolk,
      VA 23529, USA. ypearson@odu.edu
FAU - Borenstein, Jason
AU  - Borenstein J
LA  - eng
PT  - Journal Article
DEP - 20110915
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Adolescent
MH  - Caregivers/*ethics
MH  - Child
MH  - Child Development
MH  - Cognition Disorders/*therapy
MH  - *Disabled Persons
MH  - Humans
MH  - *Play and Playthings
MH  - Robotics/*ethics
EDAT- 2011/09/16 06:00
MHDA- 2013/12/16 06:00
CRDT- 2011/09/16 06:00
PHST- 2011/05/20 00:00 [received]
PHST- 2011/09/06 00:00 [accepted]
PHST- 2011/09/16 06:00 [entrez]
PHST- 2011/09/16 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1007/s11948-011-9309-8 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Mar;19(1):123-37. doi: 10.1007/s11948-011-9309-8. Epub 2011 
      Sep 15.


PMID- 21918887
OWN - NLM
STAT- MEDLINE
DCOM- 20111202
LR  - 20211020
IS  - 1573-3394 (Electronic)
IS  - 1065-3058 (Linking)
VI  - 19
IP  - 3
DP  - 2011 Sep
TI  - Withdrawing from research: a rethink in the context of research biobanks.
PG  - 269-81
LID - 10.1007/s10728-011-0194-8 [doi]
AB  - It is generally assumed in research ethics that research participants have an
      unconditional right to withdraw from research without any detriment or reprisal. 
      This paper analyses this right in the context of biobank research and argues that
      the traditional shape of the right in clinical research can be modified in
      biobank research without incurring significant ethical cost. The paper falls in
      three parts. The first part is a brief explication of the philosophical
      justification of the right to withdraw. The second part presents a number of
      extant criticisms of the right. And the third and final part argues that although
      a right to withdraw is crucial in relation to biobank research, such a right has 
      to be specified in a different way to the similar right in relation to clinical
      research.
FAU - Holm, Soren
AU  - Holm S
AD  - Centre for Social Ethics and Policy, School of Law, University of Manchester, UK.
      soren.holm@manchester.ac.uk
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Health Care Anal
JT  - Health care analysis : HCA : journal of health philosophy and policy
JID - 9432537
MH  - Biological Specimen Banks/*ethics
MH  - *Ethics, Research
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Personal Autonomy
MH  - Refusal to Participate/*ethics
MH  - Research Subjects
EDAT- 2011/09/16 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/09/16 06:00
PHST- 2011/09/16 06:00 [entrez]
PHST- 2011/09/16 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/s10728-011-0194-8 [doi]
PST - ppublish
SO  - Health Care Anal. 2011 Sep;19(3):269-81. doi: 10.1007/s10728-011-0194-8.


PMID- 21918811
OWN - NLM
STAT- MEDLINE
DCOM- 20120522
LR  - 20211020
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 23
IP  - 4
DP  - 2011 Dec
TI  - Emotions and clinical ethics support. A moral inquiry into emotions in moral case
      deliberation.
PG  - 257-68
LID - 10.1007/s10730-011-9162-9 [doi]
AB  - Emotions play an important part in moral life. Within clinical ethics support
      (CES), one should take into account the crucial role of emotions in moral cases
      in clinical practice. In this paper, we present an Aristotelian approach to
      emotions. We argue that CES can help participants deal with emotions by fostering
      a joint process of investigation of the role of emotions in a case. This
      investigation goes beyond empathy with and moral judgment of the emotions of the 
      case presenter. In a moral case deliberation, the participants are invited to
      place themselves in the position of the case presenter and to investigate their
      own emotions in the situation. It is about critically assessing the facts in the 
      case that cause the emotion and the related (moral) thoughts that accompany the
      emotion. It is also about finding the right emotion in a given situation and
      finding the right balance in dealing with that emotion. These steps in the moral 
      inquiry give rise to group learning. It is a process of becoming open towards the
      perspectives of others, leading to new insights into what is an appropriate
      emotion in the specific situation. We show how this approach works in moral case 
      deliberation. A physician presents a situation in which he is faced with a
      pregnant woman who is about to deliver multiple extremely premature infants at
      the threshold of viability. The moral deliberation of the case and the emotions
      therein leads to the participants' conclusion that "compassion" is a more
      adequate emotion than "sadness". The emotion "sadness" is pointed towards the
      tragedy that is happening to the woman. The emotion "compassion" is pointed
      towards the woman; it combines consideration and professional responsibility.
      Through the shift towards compassion, participants experienced more creativity
      and freedom to deal with the sad situation and to support the woman. The paper
      ends with an analysis and reflection on the deliberation process. In the
      conclusion we argue for more attention to emotions in clinical ethics support and
      offer some directions for doing this in the right way.
FAU - Molewijk, Bert
AU  - Molewijk B
AD  - Department of Medical Humanities, EMGO Institute for Health and Care Research, VU
      University Medical Centre, Amsterdam, The Netherlands. b.molewijk@vumc.nl
FAU - Kleinlugtenbelt, Dick
AU  - Kleinlugtenbelt D
FAU - Pugh, Scott M
AU  - Pugh SM
FAU - Widdershoven, Guy
AU  - Widdershoven G
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - Decision Making/*ethics
MH  - Delivery of Health Care
MH  - *Emotions
MH  - *Ethics Committees, Clinical
MH  - Humans
MH  - *Morals
MH  - Philosophy
EDAT- 2011/09/16 06:00
MHDA- 2012/05/23 06:00
CRDT- 2011/09/16 06:00
PHST- 2011/09/16 06:00 [entrez]
PHST- 2011/09/16 06:00 [pubmed]
PHST- 2012/05/23 06:00 [medline]
AID - 10.1007/s10730-011-9162-9 [doi]
PST - ppublish
SO  - HEC Forum. 2011 Dec;23(4):257-68. doi: 10.1007/s10730-011-9162-9.


PMID- 21918487
OWN - NLM
STAT- MEDLINE
DCOM- 20120302
LR  - 20111024
IS  - 1539-0683 (Electronic)
IS  - 0361-929X (Linking)
VI  - 36
IP  - 6
DP  - 2011 Nov-Dec
TI  - Cord blood banking: what nurses and healthcare providers should know.
PG  - 344-50; quiz 351-2
LID - 10.1097/NMC.0b013e31822db253 [doi]
AB  - Although the use of embryonic stem cells to treat disease has caused much
      controversy, one type of stem cell treatment has slowly and steadily shown
      promise but has not engendered negative ethical media attention: the use of
      umbilical stem cells. Umbilical cord blood (UCB) contains stem cells that have
      already successfully treated a variety of diseases, including leukemias,
      lymphomas, hemoglobinopathies, immunodeficiencies, and disorders of metabolism;
      ongoing research continues to explore additional diseases for potential
      treatment. Cord blood can be stored in private banks or public banks. Private
      cord blood banks save cord blood for use by the family only, at a cost. Public
      cord blood banks accept donations and the cord blood is then used for the general
      public and/or research. A review of the literature finds that public banking is
      the preferred recommendation over private unless there is a known family member
      with a disease that can currently be treated with cord blood. This article
      discusses cord blood banking options as well as the ethical issues and barriers
      facing both healthcare providers and patients when dealing with cord blood
      banking.
FAU - Abdullah, Yasmin
AU  - Abdullah Y
AD  - Yasmin Abdullah is a Family Nurse Practitioner, La Rabida Children's Hospital,
      Chicago, IL, USA. yabdullah@larabida.org.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - MCN Am J Matern Child Nurs
JT  - MCN. The American journal of maternal child nursing
JID - 7605941
SB  - IM
MH  - *Blood Banks/ethics/organization & administration
MH  - Cord Blood Stem Cell Transplantation
MH  - Cordocentesis
MH  - *Fetal Blood
MH  - Humans
MH  - Private Sector
MH  - Public Sector
MH  - United States
EDAT- 2011/09/16 06:00
MHDA- 2012/03/03 06:00
CRDT- 2011/09/16 06:00
PHST- 2011/09/16 06:00 [entrez]
PHST- 2011/09/16 06:00 [pubmed]
PHST- 2012/03/03 06:00 [medline]
AID - 10.1097/NMC.0b013e31822db253 [doi]
PST - ppublish
SO  - MCN Am J Matern Child Nurs. 2011 Nov-Dec;36(6):344-50; quiz 351-2. doi:
      10.1097/NMC.0b013e31822db253.


PMID- 21918387
OWN - NLM
STAT- MEDLINE
DCOM- 20120118
LR  - 20151119
IS  - 1539-2031 (Electronic)
IS  - 0192-0790 (Linking)
VI  - 45
IP  - 9
DP  - 2011 Oct
TI  - A very high rate of inappropriate use of gastroprotection for nonsteroidal
      anti-inflammatory drug therapy in primary care: a cross-sectional study.
PG  - 780-4
LID - 10.1097/MCG.0b013e3182151be7 [doi]
AB  - AIM: To assess the appropriateness of gastroprotection in nonsteroidal
      anti-inflammatory drug (NSAID) users by primary care physicians. BACKGROUND: A
      gastroprotective therapy is advised in NSAID users who are at a high risk for
      developing gastrointestinal side effects. However, an inappropriate
      (overuse/underuse) prescription of gastroprotection has been reported. STUDY:
      This was a cross-sectional study in which a questionnaire was administered to
      consecutive NSAID users who visited routine primary care during a 1-week period. 
      The presence of risk factors for NSAID-related gastrointestinal side effects and 
      the eventual gastroprotective strategy used were registered. Gastroprotective
      therapy was considered appropriate/inappropriate according to the current
      guidelines. RESULTS: Overall, 869 (25.3%) of 3,433 patients were on chronic NSAID
      therapy. Gastroprotection was performed in 593 (68.2%) NSAID users, and it was
      appropriate in only 299 (34.4%) cases. Specifically, an underuse of
      gastroprotective therapy was observed in 30.6% of >/=65-year-old, whereas an
      overuse occurred in 57.5% of <65-year-old patients without any risk factor.
      Concomitant therapy with either steroids [odds ratio (OR): 4.3] or anticoagulants
      (OR: 3.9), and >72 years of age (OR: 1.67) were significant predictive factors of
      inappropriate gastroprotection. CONCLUSIONS: Appropriate use of gastroprotective 
      therapy for NSAID users by primary care physicians needs to be promptly
      implemented, as its inappropriate use is noticeably increasing ethical and
      economic concerns.
FAU - Morini, Sergio
AU  - Morini S
AD  - Gastroenterology and Digestive Endoscopy, Nuovo Regina Margherita Hospital, Rome,
      Italy. sergio.morini@gmail.com
FAU - Zullo, Angelo
AU  - Zullo A
FAU - Oliveti, Diodato
AU  - Oliveti D
FAU - Chiriatti, Alberto
AU  - Chiriatti A
FAU - Marmo, Riccardo
AU  - Marmo R
FAU - Chiuri, Diana A E
AU  - Chiuri DA
FAU - Marotti, Gemma
AU  - Marotti G
FAU - Morelli, Lara
AU  - Morelli L
FAU - Hassan, Cesare
AU  - Hassan C
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Gastroenterol
JT  - Journal of clinical gastroenterology
JID - 7910017
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Anti-Ulcer Agents)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anti-Inflammatory Agents, Non-Steroidal/*adverse effects
MH  - Anti-Ulcer Agents/administration & dosage/*therapeutic use
MH  - Cross-Sectional Studies
MH  - Female
MH  - Gastrointestinal Diseases/chemically induced/*prevention & control
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Practice Patterns, Physicians'/standards
MH  - Primary Health Care/standards
MH  - Risk Factors
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2011/09/16 06:00
MHDA- 2012/01/19 06:00
CRDT- 2011/09/16 06:00
PHST- 2011/09/16 06:00 [entrez]
PHST- 2011/09/16 06:00 [pubmed]
PHST- 2012/01/19 06:00 [medline]
AID - 10.1097/MCG.0b013e3182151be7 [doi]
AID - 00004836-201110000-00011 [pii]
PST - ppublish
SO  - J Clin Gastroenterol. 2011 Oct;45(9):780-4. doi: 10.1097/MCG.0b013e3182151be7.


PMID- 21917767
OWN - NLM
STAT- MEDLINE
DCOM- 20120111
LR  - 20220318
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Linking)
VI  - 77
IP  - 15
DP  - 2011 Oct 11
TI  - Addressing the ethical, policy, and social challenges of preclinical Alzheimer
      disease.
PG  - 1487-93
LID - 10.1212/WNL.0b013e318232ac1a [doi]
AB  - Research suggests that Alzheimer disease (AD) pathophysiology begins prior to the
      clinical expression of the disease and that biomarker measures may provide direct
      evidence of this process. As a result, it may be possible to uncouple the
      diagnosis of AD from the clinical expression of the disease. The shifting
      boundaries between normal brain aging and disease present 3 challenges: 1)
      establishing guidelines for researchers and clinicians to safely and effectively 
      communicate the diagnosis of preclinical AD, 2) setting up a process that
      effectively translates this diagnosis into practice and policy, and 3) adapting
      laws, regulations, and professional practices to the diagnosis of preclinical AD.
      The field of genetic testing for AD suggests how to balance a patient's desire to
      know his or her risk of developing dementia with a clinician's desire to mitigate
      the potential harms of that information. The development of diagnostic and
      treatment guidelines for other diseases of aging, such as cardiovascular disease,
      suggests the need for a National Alzheimer's Education Program to develop
      policies and procedures to translate preclinical AD into both clinical practice
      and policy. Revisions are needed to laws, regulations, and professional practices
      governing driving, financial management and planning, and privacy and
      confidentiality.
FAU - Karlawish, Jason
AU  - Karlawish J
AD  - Center for Neuroscience and Society, Alzheimer's Disease Center, Center for
      Bioethics, Departments of Medicine and Medical Ethics, University of
      Pennsylvania, Philadelphia, PA 19104, USA. Jason.Karlawish@uphs.upenn.edu
LA  - eng
GR  - P30 AG010124/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110914
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
SB  - IM
MH  - Alzheimer Disease/*diagnosis/*therapy
MH  - *Biomedical Research/ethics/methods/standards
MH  - Female
MH  - *Health Occupations/ethics/legislation & jurisprudence/standards
MH  - *Health Policy
MH  - Humans
MH  - Male
MH  - Risk Assessment
PMC - PMC4561233
EDAT- 2011/09/16 06:00
MHDA- 2012/01/12 06:00
CRDT- 2011/09/16 06:00
PHST- 2011/09/16 06:00 [entrez]
PHST- 2011/09/16 06:00 [pubmed]
PHST- 2012/01/12 06:00 [medline]
AID - WNL.0b013e318232ac1a [pii]
AID - 10.1212/WNL.0b013e318232ac1a [doi]
PST - ppublish
SO  - Neurology. 2011 Oct 11;77(15):1487-93. doi: 10.1212/WNL.0b013e318232ac1a. Epub
      2011 Sep 14.


PMID- 21917556
OWN - NLM
STAT- MEDLINE
DCOM- 20120215
LR  - 20111004
IS  - 1542-6270 (Electronic)
IS  - 1060-0280 (Linking)
VI  - 45
IP  - 10
DP  - 2011 Oct
TI  - The vaccine-autism connection: a public health crisis caused by unethical medical
      practices and fraudulent science.
PG  - 1302-4
LID - 10.1345/aph.1Q318 [doi]
AB  - In 1998, Dr. Andrew Wakefield, a British gastroenterologist, described a new
      autism phenotype called the regressive autism-enterocolitis syndrome triggered by
      environmental factors such as measles, mumps, and rubella (MMR) vaccination. The 
      speculative vaccination-autism connection decreased parental confidence in public
      health vaccination programs and created a public health crisis in England and
      questions about vaccine safety in North America. After 10 years of controversy
      and investigation, Dr. Wakefield was found guilty of ethical, medical, and
      scientific misconduct in the publication of the autism paper. Additional studies 
      showed that the data presented were fraudulent. The alleged autism-vaccine
      connection is, perhaps, the most damaging medical hoax of the last 100 years.
FAU - Flaherty, Dennis K
AU  - Flaherty DK
AD  - Department of Pharmaceutical and Administrative Sciences, University of
      Charleston School of Pharmacy, Charleston, WV, USA. dennisflaherty@ucwv.edu
LA  - eng
PT  - Journal Article
DEP - 20110913
PL  - United States
TA  - Ann Pharmacother
JT  - The Annals of pharmacotherapy
JID - 9203131
RN  - 0 (Vaccines)
SB  - IM
MH  - Attitude to Health
MH  - Autistic Disorder/*etiology
MH  - Child
MH  - Evidence-Based Medicine
MH  - Health Promotion
MH  - Humans
MH  - Parents/psychology
MH  - Patient Education as Topic
MH  - Professional Misconduct
MH  - *Scientific Misconduct
MH  - Treatment Refusal/psychology
MH  - Vaccines/*adverse effects
EDAT- 2011/09/16 06:00
MHDA- 2012/02/16 06:00
CRDT- 2011/09/16 06:00
PHST- 2011/09/16 06:00 [entrez]
PHST- 2011/09/16 06:00 [pubmed]
PHST- 2012/02/16 06:00 [medline]
AID - aph.1Q318 [pii]
AID - 10.1345/aph.1Q318 [doi]
PST - ppublish
SO  - Ann Pharmacother. 2011 Oct;45(10):1302-4. doi: 10.1345/aph.1Q318. Epub 2011 Sep
      13.


PMID- 21916779
OWN - NLM
STAT- MEDLINE
DCOM- 20120110
LR  - 20181201
IS  - 1477-2566 (Electronic)
IS  - 1465-3249 (Linking)
VI  - 13
IP  - 9
DP  - 2011 Oct
TI  - Isolation and basic characterization of human term amnion and chorion mesenchymal
      stromal cells.
PG  - 1047-56
LID - 10.3109/14653249.2011.592522 [doi]
AB  - BACKGROUND AIMS: Emerging evidence suggests human placental membrane is a
      valuable source of mesenchymal stromal cells (MSC). Amnion and chorion are
      tissues of early embryologic origin that may entail progenitor potential. These
      tissues are abundantly available and ethically unobjectionable and, because they 
      are discarded post-partum, they can be widely used for extensive research and
      eventually for therapeutic studies. METHODS: We looked at the cells isolated from
      the six amnions and chorions of term placentas of gestational weeks 39 +/- 1.
      Isolated cells were characterized by morphologic and immunophenotypic analysis.
      RESULTS: With flow cytometry immunophenotype analysis, amnion- and
      chorion-derived cells were positive for MSC markers, and negative for
      hematopoietic markers. Immunocytochemical staining was positive for the embryonic
      cell markers Oct-3/4 and Rex-1. Oct-3/4 is a POU transcription factor that is
      expressed in embryonic stem (ES) cells and germ cells, and its expression is
      required to sustain cell self-renewal and pluripotency. Oct-3/4 is the most
      recognized marker for totipotent ES cells. Rex-1 is a zinc finger family
      transcription factor that is highly expressed in embryonic stem cells. It is one 
      of several gene markers used to identify undifferentiated stem cells, and its
      expression is downregulated upon stem cell differentiation. Amnion- and
      chorion-derived cells were capable, under differentiation conditions, to
      differentiate into to mesoderm lineages. CONCLUSIONS: Phenotypic studies indicate
      MSC-like profiles in both amnion- and chorion-derived cells. Cells in vitro had
      fibroblastoid morphology. The in vitro growth behavior of such placenta-derived
      progenitor cells was similar to that of bone marrow MSC. Our results indicate
      that MSC can be easily isolated from the human term placenta. The human amniotic 
      and chorion MSC maintained a marker profile similar to the mesenchymal
      progenitors and could be used for studies as an alternative source of MSC for
      further application in cellular therapy.
FAU - Bacenkova, Darina
AU  - Bacenkova D
AD  - Tissue Bank, PJ Safarik University, Trieda SNP 1, Kosice, Slovakia.
FAU - Rosocha, Jan
AU  - Rosocha J
FAU - Tothova, Timea
AU  - Tothova T
FAU - Rosocha, Ladislav
AU  - Rosocha L
FAU - Sarissky, Marek
AU  - Sarissky M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Cytotherapy
JT  - Cytotherapy
JID - 100895309
RN  - 0 (Kruppel-Like Transcription Factors)
RN  - 0 (Octamer Transcription Factor-3)
RN  - 0 (POU Domain Factors)
RN  - 0 (POU5F1 protein, human)
RN  - 0 (ZFP42 protein, human)
SB  - IM
MH  - Amnion/*cytology
MH  - Cell Differentiation
MH  - Cell Separation
MH  - Cells, Cultured
MH  - Chorion/*cytology
MH  - Feasibility Studies
MH  - Female
MH  - Flow Cytometry
MH  - Humans
MH  - Immunohistochemistry
MH  - Immunophenotyping
MH  - Kruppel-Like Transcription Factors/metabolism
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Mesenchymal Stem Cells/cytology/*metabolism
MH  - Octamer Transcription Factor-3/metabolism
MH  - POU Domain Factors/metabolism
MH  - Pregnancy
MH  - Term Birth/*physiology
EDAT- 2011/09/16 06:00
MHDA- 2012/01/11 06:00
CRDT- 2011/09/16 06:00
PHST- 2011/09/16 06:00 [entrez]
PHST- 2011/09/16 06:00 [pubmed]
PHST- 2012/01/11 06:00 [medline]
AID - 10.3109/14653249.2011.592522 [doi]
AID - S1465-3249(11)70586-2 [pii]
PST - ppublish
SO  - Cytotherapy. 2011 Oct;13(9):1047-56. doi: 10.3109/14653249.2011.592522.


PMID- 21916741
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20191210
IS  - 1545-5815 (Electronic)
IS  - 0898-9621 (Linking)
VI  - 18
IP  - 5
DP  - 2011 Sep-Oct
TI  - Impact on parents of receiving individualized feedback of psychological testing
      conducted with children as part of a research study.
PG  - 342-56
LID - 10.1080/08989621.2011.606737 [doi]
AB  - While many researchers accept the principle that participants have a right to
      receive information learned from their participation in research, there are few
      studies examining the impact of receiving results on participants. This study was
      developed to examine the impact on parents of the receipt of individual results
      of research-based psychological testing of their children. A summary of the
      child's individual results of standardized measures of language and development
      was sent by mail with the questionnaire designed to assess the impact of
      receiving results. Response rate from the mailed questionnaire was 55.6%
      (n=74/133). Most parents reported the results as helpful and positive. The
      majority would receive results again. Overall, the sharing of individualized
      feedback from psychological testing conducted as part of a research study was
      well accepted by parents. This practice appears ethically permissible with
      appropriate support options for addressing participant concerns upon receiving
      the results as well options for clinical follow-up for the child.
FAU - Cox, Kelly
AU  - Cox K
AD  - Department of Pediatrics, Dalhousie University, IWK Health Centre, Halifax, Nova 
      Scotia, Canada.
FAU - Fernandez, Conrad V
AU  - Fernandez CV
FAU - Chambers, Christine T
AU  - Chambers CT
FAU - Bandstra, Nancy F
AU  - Bandstra NF
FAU - Parker, Jennifer A
AU  - Parker JA
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
PL  - United States
TA  - Account Res
JT  - Accountability in research
JID - 9100813
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biomedical Research/*ethics
MH  - Child
MH  - Child, Preschool
MH  - Emotions
MH  - Ethics, Research
MH  - *Feedback, Psychological
MH  - Female
MH  - Health Care Surveys
MH  - Helping Behavior
MH  - Humans
MH  - Infant
MH  - Male
MH  - *Parent-Child Relations
MH  - Parents/*psychology
MH  - Professional-Family Relations
MH  - *Psychological Tests
MH  - Psychology, Child/*methods
MH  - Psychometrics
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2011/09/16 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/09/16 06:00
PHST- 2011/09/16 06:00 [entrez]
PHST- 2011/09/16 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - 10.1080/08989621.2011.606737 [doi]
PST - ppublish
SO  - Account Res. 2011 Sep-Oct;18(5):342-56. doi: 10.1080/08989621.2011.606737.


PMID- 21916739
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20151119
IS  - 1545-5815 (Electronic)
IS  - 0898-9621 (Linking)
VI  - 18
IP  - 5
DP  - 2011 Sep-Oct
TI  - Investigating the effects of trauma-related research on well-being.
PG  - 297-322
LID - 10.1080/08989621.2011.584772 [doi]
AB  - Using an experimental design, we investigated the impact of participation in
      trauma-related research on well-being in a sample of 219 higher education
      students. We created five conditions that exposed participants to questions about
      life events. A sixth condition represented a control condition. Exposure
      conditions varied according to whether they contained yes/no questions about
      events that entailed stress, stigma, trauma, or sexual violation. We
      operationalized well-being by measuring positive and negative affect, state
      anxiety, and positive reactions to research. Across exposure conditions,
      participants reported low levels of negative affect and generally positive
      reactions immediately after participation. The most negative and least positive
      responses followed exposure conditions that contained questions about stressful
      events and sexual violation. We discuss implications of our findings for ethics
      review board practices.
FAU - Cook, Sarah L
AU  - Cook SL
AD  - Department of Psychology, Georgia State University, Atlanta, Georgia 30302-5010, 
      USA. scook@gsu.edu
FAU - Darnell, Doyanne
AU  - Darnell D
FAU - Anthony, Elizabeth R
AU  - Anthony ER
FAU - Tusher, Chantal Poister
AU  - Tusher CP
FAU - Zimmerman, Lindsey
AU  - Zimmerman L
FAU - Enkhtor, Dulamdary
AU  - Enkhtor D
FAU - Hipp, Tracy N
AU  - Hipp TN
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Account Res
JT  - Accountability in research
JID - 9100813
SB  - IM
MH  - *Adaptation, Psychological
MH  - Adolescent
MH  - Adult
MH  - Anxiety/psychology
MH  - Confidence Intervals
MH  - Cost-Benefit Analysis
MH  - Emotions
MH  - *Ethics, Research
MH  - Female
MH  - *Happiness
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Psychometrics
MH  - Risk Assessment
MH  - Stress, Psychological/complications/*psychology
MH  - Students/psychology
MH  - Surveys and Questionnaires
MH  - Wounds and Injuries/*psychology
MH  - Young Adult
EDAT- 2011/09/16 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/09/16 06:00
PHST- 2011/09/16 06:00 [entrez]
PHST- 2011/09/16 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - 10.1080/08989621.2011.584772 [doi]
PST - ppublish
SO  - Account Res. 2011 Sep-Oct;18(5):297-322. doi: 10.1080/08989621.2011.584772.


PMID- 21916682
OWN - NLM
STAT- MEDLINE
DCOM- 20111123
LR  - 20110915
IS  - 1545-5882 (Electronic)
IS  - 0145-9740 (Linking)
VI  - 30
IP  - 5
DP  - 2011 Sep-Oct
TI  - Canada's non-status immigrants: negotiating access to health care and
      citizenship.
PG  - 496-517
LID - 10.1080/01459740.2011.579586 [doi]
AB  - Illegal immigration in Canada is characterized mainly by non-status immigrants
      who legally enter Canada and stay after their legal status expires and by failed 
      refugee claimants. For these persons, immigration status or its absence plays an 
      important role in determining the degree of access to Canadian health care. This 
      article situates the clinical setting as a site of contention and negotiation of 
      citizenship and care in social networks as well as pragmatic and discursive
      strategies. Drawing on the case of a patient who faced imminent deportation and
      became suicidal, in this article I depict how psychiatrists and other health
      practitioners embrace "bearing witness" as an ethical practice, which intersects 
      the medical and legal spheres.
FAU - Miklavcic, Alessandra
AU  - Miklavcic A
AD  - Division of Social and Transcultural Psychiatry, McGill University, and Douglas
      Hospital Research Centre, Montreal, Quebec, Canada.
      alessandra.miklavcic@mail.mcgill.ca
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Med Anthropol
JT  - Medical anthropology
JID - 7707343
SB  - IM
MH  - *Anthropology, Medical
MH  - Canada
MH  - Emigrants and Immigrants
MH  - *Health Services Accessibility
MH  - *Human Rights
MH  - Humans
MH  - Mental Health
MH  - Socioeconomic Factors
MH  - *Transients and Migrants
EDAT- 2011/09/16 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/09/16 06:00
PHST- 2011/09/16 06:00 [entrez]
PHST- 2011/09/16 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1080/01459740.2011.579586 [doi]
PST - ppublish
SO  - Med Anthropol. 2011 Sep-Oct;30(5):496-517. doi: 10.1080/01459740.2011.579586.


PMID- 21916349
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20110915
IS  - 0097-9805 (Print)
IS  - 0097-9805 (Linking)
VI  - 37
IP  - 4
DP  - 2011 Jul-Aug
TI  - Great summer reads and family-centered care, all in one!
PG  - 207-9
AB  - Award-winning author Jodi Picoult has written several novels that dramatically
      portray families caught in personal, financial, medical, legal, and ethical
      dilemmas related to their children having medical or developmental challenges. At
      times drawing on personal experience but always conducting extensive background
      research, Picoult's work is very realistic in its depiction of varied child and
      family scenarios. These gripping stories, while fiction, point clearly to real
      issues and highlight the need for and importance of a family-centered approach in
      pediatric care. Pediatric nurses can confidently pick up a Picoult novel for an
      entertaining and thought-provoking summer read.
FAU - Ahmann, Elizabeth
AU  - Ahmann E
FAU - Dokken, Deborah
AU  - Dokken D
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pediatr Nurs
JT  - Pediatric nursing
JID - 7505804
MH  - *Family
MH  - Humans
MH  - *Patient-Centered Care
MH  - *Reading
EDAT- 2011/09/16 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/09/16 06:00
PHST- 2011/09/16 06:00 [entrez]
PHST- 2011/09/16 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
PST - ppublish
SO  - Pediatr Nurs. 2011 Jul-Aug;37(4):207-9.


PMID- 21916322
OWN - NLM
STAT- MEDLINE
DCOM- 20111028
LR  - 20190513
IS  - 0026-4075 (Print)
IS  - 0026-4075 (Linking)
VI  - 176
IP  - 7 Suppl
DP  - 2011 Jul
TI  - Protecting those who serve.
PG  - 1-4
AB  - The May 19 to 21, 2010 symposium "Assessing Potentially Hazardous Environmental
      Exposures Among Military Populations" brought military and civilian preventive
      medicine practitioners and scientists together to review the current state of
      exposure and outcome measurement, prevention, and compensation. Placed in recent 
      historical context, the strides presented are remarkable, yet important
      challenges remain. Operational as well as ethical imperatives within the military
      and the growing complexity of civilian disasters demonstrate the need for
      continued and enhanced collaboration across military and civilian sectors.
FAU - Sokas, Rosemary K
AU  - Sokas RK
LA  - eng
PT  - Congress
PT  - Editorial
PL  - England
TA  - Mil Med
JT  - Military medicine
JID - 2984771R
RN  - 0 (Hazardous Substances)
SB  - IM
MH  - Environmental Exposure/*prevention & control
MH  - Hazardous Substances/adverse effects
MH  - Humans
MH  - Maryland
MH  - Military Medicine
MH  - *Military Personnel
MH  - Occupational Diseases/prevention & control
MH  - *Public Health Practice
MH  - United States
EDAT- 2011/09/16 06:00
MHDA- 2011/10/29 06:00
CRDT- 2011/09/16 06:00
PHST- 2011/09/16 06:00 [entrez]
PHST- 2011/09/16 06:00 [pubmed]
PHST- 2011/10/29 06:00 [medline]
AID - 10.7205/milmed-d-11-00093 [doi]
PST - ppublish
SO  - Mil Med. 2011 Jul;176(7 Suppl):1-4. doi: 10.7205/milmed-d-11-00093.


PMID- 21908702
OWN - NLM
STAT- MEDLINE
DCOM- 20120814
LR  - 20110912
IS  - 1938-744X (Electronic)
IS  - 1935-7893 (Linking)
VI  - 5 Suppl 2
DP  - 2011 Sep
TI  - Building evidence for legal decision making in real time: legal triage in public 
      health emergencies.
PG  - S242-51
LID - 10.1001/dmp.2011.57 [doi]
AB  - Similar to the triaging of patients by health care workers, legal and public
      health professionals must prioritize and respond to issues of law and ethics in
      declared public health emergencies. As revealed by the 2009-2010 H1N1 influenza
      outbreak and other events, there are considerable inconsistencies among
      professionals regarding how to best approach these issues during a public health 
      emergency. Our project explores these inconsistencies by attempting to assess how
      practitioners make legal and ethical decisions in real-time emergencies to
      further critical public health objectives. Using a fictitious scenario and
      interactive visualization environment, we observed real-time decision-making
      processes among knowledgeable participants. Although participants' decisions and 
      perspectives varied, the exercise demonstrated an increase in the perception of
      the relevance of legal preparedness in multiple aspects of the decision-making
      process and some key lessons learned for consideration in future repetitions of
      the exercise and actual, real-time emergency events.
FAU - Hodge, James G Jr
AU  - Hodge JG Jr
AD  - ASU Sandra Day O'Connor College of Law, Ross-Blakley Library, Room 318, PO Box
      877906, Tempe, AZ 85287-79906, USA. james.hodge.1@asu.edu
FAU - Lant, Timothy
AU  - Lant T
FAU - Arias, Jalayne
AU  - Arias J
FAU - Jehn, Megan
AU  - Jehn M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Disaster Med Public Health Prep
JT  - Disaster medicine and public health preparedness
JID - 101297401
SB  - IM
MH  - *Decision Making/ethics
MH  - Decision Support Techniques
MH  - *Emergencies
MH  - Health Personnel/legislation & jurisprudence
MH  - Humans
MH  - Jurisprudence
MH  - Liability, Legal
MH  - Public Health/ethics/*legislation & jurisprudence
MH  - Triage
EDAT- 2011/09/16 06:00
MHDA- 2012/08/15 06:00
CRDT- 2011/09/13 06:00
PHST- 2011/09/13 06:00 [entrez]
PHST- 2011/09/16 06:00 [pubmed]
PHST- 2012/08/15 06:00 [medline]
AID - 5/Supplement_2/S242 [pii]
AID - 10.1001/dmp.2011.57 [doi]
PST - ppublish
SO  - Disaster Med Public Health Prep. 2011 Sep;5 Suppl 2:S242-51. doi:
      10.1001/dmp.2011.57.


PMID- 21905989
OWN - NLM
STAT- MEDLINE
DCOM- 20120306
LR  - 20211020
IS  - 1814-1412 (Electronic)
IS  - 1562-2975 (Linking)
VI  - 12 Suppl 1
DP  - 2011 Sep
TI  - Gene therapy for psychiatric disorders.
PG  - 16-8
LID - 10.3109/15622975.2011.601927 [doi]
AB  - There is no indication that gene therapy can be applied in psychiatric patients
      any time soon. However, there are several promising developments on the level of 
      experimental neuroscience indicating that gene therapy approaches have an effect 
      in animal models of several psychiatric disorders including drug addiction,
      affective disorders, psychoses and dementia, modifying behavioural parameters via
      interventions on the molecular and cellular level. However, before gene therapy
      in psychiatric disorders can be considered on the human level, not only
      neurobiological and technical problems need to be overcome, but also important
      ethical questions answered.
FAU - Thome, Johannes
AU  - Thome J
AD  - Clinic and Policlinic for Psychiatry and Psychotherapy, University of Rostock,
      Rostock, Germany. johannes.thome@med.uni-rostock.de
FAU - Hassler, Frank
AU  - Hassler F
FAU - Zachariou, Vanna
AU  - Zachariou V
LA  - eng
GR  - P01 DA008227/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - England
TA  - World J Biol Psychiatry
JT  - The world journal of biological psychiatry : the official journal of the World
      Federation of Societies of Biological Psychiatry
JID - 101120023
SB  - IM
MH  - Affective Disorders, Psychotic/genetics/physiopathology/rehabilitation
MH  - Alzheimer Disease/genetics/physiopathology/rehabilitation
MH  - Animals
MH  - Brain/physiopathology
MH  - Depressive Disorder, Major/genetics/physiopathology/rehabilitation
MH  - Disease Models, Animal
MH  - Gene Expression Regulation/genetics/physiology
MH  - Gene Transfer Techniques
MH  - Genetic Therapy/*methods
MH  - Humans
MH  - Mental Disorders/*genetics/physiopathology/*rehabilitation
MH  - Nerve Regeneration/genetics/physiology
MH  - Neuronal Plasticity/genetics/physiology
MH  - Psychotic Disorders/genetics/physiopathology/rehabilitation
MH  - Substance-Related Disorders/genetics/physiopathology/rehabilitation
PMC - PMC3394098
MID - NIHMS385941
EDAT- 2011/09/16 06:00
MHDA- 2012/03/07 06:00
CRDT- 2011/09/13 06:00
PHST- 2011/09/13 06:00 [entrez]
PHST- 2011/09/16 06:00 [pubmed]
PHST- 2012/03/07 06:00 [medline]
AID - 10.3109/15622975.2011.601927 [doi]
PST - ppublish
SO  - World J Biol Psychiatry. 2011 Sep;12 Suppl 1:16-8. doi:
      10.3109/15622975.2011.601927.


PMID- 21916022
OWN - NLM
STAT- MEDLINE
DCOM- 20120215
LR  - 20160511
IS  - 1942-7611 (Electronic)
IS  - 1942-7603 (Linking)
VI  - 3
IP  - 10
DP  - 2011 Oct
TI  - In vitro metabolism of tiletamine, zolazepam and nonbenzodiazepine sedatives:
      Identification of target metabolites for equine doping control.
PG  - 705-16
LID - 10.1002/dta.300 [doi]
AB  - Within horseracing, the detection of prohibited substance doping often requires
      urine analysis; hence, it is necessary to understand the metabolism of the drugs 
      in question. Here, the previously unknown equine metabolism of eight sedatives is
      reported in order to provide information on target metabolites for use in doping 
      control. Phase I metabolite information was provided by incubation with equine
      liver S9 fraction. In vitro techniques were chosen in order to reduce the ethical
      and financial issues surrounding the study of so many compounds, none of which
      are licensed for use in horses in the UK. Several metabolites of each drug were
      identified using liquid chromatography-high resolution mass spectrometric
      (LC-HRMS) analysis on an LTQ-Orbitrap. Further structural information was
      obtained by tandem mass spectrometry (MS/MS) analysis; allowing postulation of
      the structure of some of the most abundant in vitro metabolites. The most
      abundant metabolites of alpidem, etifoxine, indiplon, tiletamine, zaleplon,
      zolazepam, zolpidem, and zopiclone related to hydroxylation/N-oxidation,
      deethylation, demethylation, deethylation, hydroxylation/N-oxidation,
      demethylation, hydroxylation/N-oxidation and hydroxylation/N-oxidation,
      respectively. In many cases, further work would be required to fully elucidate
      the precise positioning of the functional groups involved. The results of this
      study provide metabolite information that can be used to enhance equine
      anti-doping screening methods. However, the in vitro metabolites identified are
      at present only a prediction of those that may occur in vivo. In the future, any 
      positive findings of these drugs and/or their metabolites in horse urine samples 
      could help validate these findings and/or refine the choice of target
      metabolites.
CI  - Copyright (c) 2011 John Wiley & Sons, Ltd.
FAU - Fenwick, Susanna J
AU  - Fenwick SJ
AD  - HFL Sport Science Ltd, Newmarket Road, Fordham, Cambridgeshire, CB7 5WW, UK.
      sfenwick@hfl.co.uk
FAU - Scarth, James P
AU  - Scarth JP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110914
PL  - England
TA  - Drug Test Anal
JT  - Drug testing and analysis
JID - 101483449
RN  - 0 (Central Nervous System Depressants)
RN  - 2YFC543249 (Tiletamine)
RN  - G1R474U58U (Zolazepam)
SB  - IM
MH  - Animals
MH  - Central Nervous System Depressants/*metabolism
MH  - Chromatography, Liquid/methods
MH  - *Doping in Sports
MH  - Horses/*metabolism
MH  - Liver/drug effects/metabolism
MH  - *Substance Abuse Detection/methods
MH  - Tandem Mass Spectrometry/methods
MH  - Tiletamine/*metabolism
MH  - Zolazepam/*metabolism
EDAT- 2011/09/15 06:00
MHDA- 2012/02/16 06:00
CRDT- 2011/09/15 06:00
PHST- 2010/12/02 00:00 [received]
PHST- 2011/03/16 00:00 [revised]
PHST- 2011/04/29 00:00 [accepted]
PHST- 2011/09/15 06:00 [entrez]
PHST- 2011/09/15 06:00 [pubmed]
PHST- 2012/02/16 06:00 [medline]
AID - 10.1002/dta.300 [doi]
PST - ppublish
SO  - Drug Test Anal. 2011 Oct;3(10):705-16. doi: 10.1002/dta.300. Epub 2011 Sep 14.


PMID- 21915286
OWN - NLM
STAT- MEDLINE
DCOM- 20120214
LR  - 20211020
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 6
IP  - 9
DP  - 2011
TI  - Towards a new paradigm of non-captive research on cetacean cognition.
PG  - e24121
LID - 10.1371/journal.pone.0024121 [doi]
AB  - Contemporary knowledge of impressive neurophysiology and behavior in cetaceans,
      combined with increasing opportunities for studying free-ranging cetaceans who
      initiate sociable interaction with humans, are converging to highlight serious
      ethical considerations and emerging opportunities for a new era of progressive
      and less-invasive cetacean research. Most research on cetacean cognition has
      taken place in controlled captive settings, e.g., research labs, marine parks.
      While these environments afford a certain amount of experimental rigor and
      logistical control they are fraught with limitations in external validity, impose
      tremendous stress on the part of the captive animals, and place burdens on
      populations from which they are often captured. Alternatively, over the past
      three decades, some researchers have sought to focus their attention on the
      presence of free-ranging cetacean individuals and groups who have initiated, or
      chosen to participate in, sociable interactions with humans in the wild. This new
      approach, defined as Interspecies Collaborative Research between cetacean and
      human, involves developing novel ways to address research questions under natural
      conditions and respecting the individual cetacean's autonomy. It also offers a
      range of potential direct benefits to the cetaceans studied, as well as allowing 
      for unprecedented cognitive and psychological research on sociable mysticetes.
      Yet stringent precautions are warranted so as to not increase their vulnerability
      to human activities or pathogens. When conducted in its best and most responsible
      form, collaborative research with free-ranging cetaceans can deliver
      methodological innovation and invaluable new insights while not necessitating the
      ethical and scientific compromises that characterize research in captivity.
      Further, it is representative of a new epoch in science in which research is
      designed so that the participating cetaceans are the direct recipients of the
      benefits.
FAU - Marino, Lori
AU  - Marino L
AD  - Department of Psychology, Emory University, Atlanta, Georgia, United States of
      America. lmarino@emory.edu
FAU - Frohoff, Toni
AU  - Frohoff T
LA  - eng
PT  - Journal Article
DEP - 20110907
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Animals
MH  - Cetacea/*physiology
MH  - Cognition/*physiology
MH  - Humans
PMC - PMC3168481
EDAT- 2011/09/15 06:00
MHDA- 2012/02/15 06:00
CRDT- 2011/09/15 06:00
PHST- 2011/09/15 06:00 [entrez]
PHST- 2011/09/15 06:00 [pubmed]
PHST- 2012/02/15 06:00 [medline]
AID - 10.1371/journal.pone.0024121 [doi]
AID - PONE-D-11-01800 [pii]
PST - ppublish
SO  - PLoS One. 2011;6(9):e24121. doi: 10.1371/journal.pone.0024121. Epub 2011 Sep 7.


PMID- 21915280
OWN - NLM
STAT- MEDLINE
DCOM- 20120214
LR  - 20220113
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 6
IP  - 9
DP  - 2011
TI  - Ethical and scientific considerations regarding animal testing and research.
PG  - e24059
LID - 10.1371/journal.pone.0024059 [doi]
FAU - Ferdowsian, Hope R
AU  - Ferdowsian HR
AD  - Physicians Committee for Responsible Medicine, Washington, DC, United States of
      America. hferdowsian@pcrm.org
FAU - Beck, Nancy
AU  - Beck N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20110907
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Animal Welfare/ethics
MH  - Animals
MH  - *Animals, Laboratory
MH  - Biomedical Research/*ethics/*standards
MH  - Humans
PMC - PMC3168484
EDAT- 2011/09/15 06:00
MHDA- 2012/02/15 06:00
CRDT- 2011/09/15 06:00
PHST- 2011/09/15 06:00 [entrez]
PHST- 2011/09/15 06:00 [pubmed]
PHST- 2012/02/15 06:00 [medline]
AID - 10.1371/journal.pone.0024059 [doi]
AID - PONE-D-11-07954 [pii]
PST - ppublish
SO  - PLoS One. 2011;6(9):e24059. doi: 10.1371/journal.pone.0024059. Epub 2011 Sep 7.


PMID- 21915253
OWN - NLM
STAT- MEDLINE
DCOM- 20120214
LR  - 20220309
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 6
IP  - 9
DP  - 2011
TI  - Pain in laboratory animals: the ethical and regulatory imperatives.
PG  - e21578
LID - 10.1371/journal.pone.0021578 [doi]
FAU - Carbone, Larry
AU  - Carbone L
AD  - Laboratory Animal Resource Center, University of California San Francisco, San
      Francisco, California, United States of America. larry.carbone@ucsf.edu
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110907
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Animal Welfare/ethics/legislation & jurisprudence
MH  - Animals
MH  - *Animals, Laboratory
MH  - Biomedical Research/ethics/legislation & jurisprudence
PMC - PMC3168441
EDAT- 2011/09/15 06:00
MHDA- 2012/02/15 06:00
CRDT- 2011/09/15 06:00
PHST- 2011/09/15 06:00 [entrez]
PHST- 2011/09/15 06:00 [pubmed]
PHST- 2012/02/15 06:00 [medline]
AID - 10.1371/journal.pone.0021578 [doi]
AID - PONE-D-11-00738 [pii]
PST - ppublish
SO  - PLoS One. 2011;6(9):e21578. doi: 10.1371/journal.pone.0021578. Epub 2011 Sep 7.


PMID- 21914914
OWN - NLM
STAT- MEDLINE
DCOM- 20120123
LR  - 20151119
IS  - 1120-9763 (Print)
IS  - 1120-9763 (Linking)
VI  - 35
IP  - 3-4
DP  - 2011 May-Aug
TI  - [End-of-life care and end-of-life medical decisions: the ITAELD study].
PG  - 178-87
AB  - OBJECTIVE: To describe the attitudes towards end of life care and the practice of
      end-of-life medical decisions with possible life-shortening effect among Italian 
      physicians. DESIGN: Cross sectional study (last death among the assisted patients
      in the last 12 months was considered). SETTING AND PARTICIPANTS: In the year
      2007, 5,710 GPs and 8,950 hospital physicians were invited all over Italy to
      participate in the ITAELDstudy through anonymous mail questionnaire. MAIN OUTCOME
      MEASURES: Proportion of agreement with statements on end-of-life care issues.
      Proportion of deaths with an end-of-life medical decision. RESULTS: The response 
      rate was 19.2%. The 65% of respondents agreed with the duty to respect any
      non-treatment request of the competent patient, the 55% agreed with the same duty
      in case of advanced directives, the 39% in case of proxy's request. The 53% of
      respondents agreed with the ethical acceptability of active euthanasia in
      selected cases. Among 1,850 deaths the 57.7% did not receive any end-of-life
      medical decision. For a further 21.0% no decision was possible, being sudden and 
      unexpected deaths. In the remaining 21.3% at least one end-of-life medical
      decision was reported: 0.8% was classified as physician assisted death, 20.5% as 
      non-treatment decision. Among all deceased the 19.6% were reported to have been
      deeply sedated. Being favourable to the use of opioids in terminal patients was
      associated to non-treatment decisions with possible but non-intentional life
      shortening effect; agreeing with the duty to fully respect any actual
      non-treatment request of the competent patient was associated to end-of life
      medical decisions with intentional life-shortening effect (adjusted OR>10 in both
      cases). CONCLUSIONS: The life stance and ethical beliefs of physicians determine 
      their behaviour at the end of life wherever specific statements of law are
      lacking. Therefore education and debate are needed on these issues.
FAU - Miccinesi, Guido
AU  - Miccinesi G
AD  - UO Epidemiologia Clinica e Descrittiva, Istituto per lo Studio e la Prevenzione
      Oncologica, ISPO, Firenze. g.miccinesi@ispo.toscana.it
FAU - Puliti, Donella
AU  - Puliti D
FAU - Paci, Eugenio
AU  - Paci E
LA  - ita
PT  - English Abstract
PT  - Journal Article
TT  - Cure di fine vita e decisioni mediche: lo studio ITAELD.
PL  - Italy
TA  - Epidemiol Prev
JT  - Epidemiologia e prevenzione
JID - 8902507
RN  - 0 (Narcotics)
SB  - IM
CIN - Epidemiol Prev. 2011 May-Aug;35(3-4):169-70. PMID: 21914909
MH  - Adult
MH  - Advance Directives
MH  - *Attitude of Health Personnel
MH  - Cross-Sectional Studies
MH  - Decision Making
MH  - Euthanasia/ethics/legislation & jurisprudence/psychology
MH  - Euthanasia, Passive/ethics/legislation & jurisprudence/*psychology
MH  - Female
MH  - General Practitioners/*psychology
MH  - Humans
MH  - Italy
MH  - Male
MH  - Middle Aged
MH  - Narcotics/adverse effects/therapeutic use
MH  - Palliative Care/ethics/psychology
MH  - Surveys and Questionnaires
MH  - Terminal Care/ethics/legislation & jurisprudence/*psychology
MH  - Third-Party Consent
EDAT- 2011/09/15 06:00
MHDA- 2012/01/24 06:00
CRDT- 2011/09/15 06:00
PHST- 2011/09/15 06:00 [entrez]
PHST- 2011/09/15 06:00 [pubmed]
PHST- 2012/01/24 06:00 [medline]
AID - 1002 [pii]
PST - ppublish
SO  - Epidemiol Prev. 2011 May-Aug;35(3-4):178-87.


PMID- 21914736
OWN - NLM
STAT- MEDLINE
DCOM- 20120227
LR  - 20181023
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 343
DP  - 2011 Sep 13
TI  - Ethical dilemmas in the acute setting: a framework for clinicians.
PG  - d5528
LID - 10.1136/bmj.d5528 [doi]
LID - bmj.d5528 [pii]
FAU - Sokol, Daniel K
AU  - Sokol DK
AD  - Department of Primary Care and Public Health, Charing Cross Campus, Imperial
      College London, London W6 8RF, UK. daniel.sokol@talk21.com
FAU - McFadzean, William A
AU  - McFadzean WA
FAU - Dickson, William A
AU  - Dickson WA
FAU - Whitaker, Iain S
AU  - Whitaker IS
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20110913
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
SB  - IM
MH  - Advance Directives/*ethics
MH  - Burns/etiology/psychology/therapy
MH  - Emergency Service, Hospital/*ethics
MH  - Female
MH  - Humans
MH  - Patient Preference
MH  - Quality of Life
MH  - Suicide, Attempted/*ethics
MH  - Tattooing
MH  - Young Adult
EDAT- 2011/09/15 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/09/15 06:00
PHST- 2011/09/15 06:00 [entrez]
PHST- 2011/09/15 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - 10.1136/bmj.d5528 [doi]
PST - epublish
SO  - BMJ. 2011 Sep 13;343:d5528. doi: 10.1136/bmj.d5528.


PMID- 21914674
OWN - NLM
STAT- MEDLINE
DCOM- 20120111
LR  - 20110928
IS  - 1758-1133 (Electronic)
IS  - 0049-4755 (Linking)
VI  - 41
IP  - 4
DP  - 2011 Oct
TI  - CD4+ T lymphocyte reference values of immunocompetent subjects in an African
      university.
PG  - 218-21
LID - 10.1258/td.2011.110219 [doi]
AB  - CD4(+) T cells play critical roles in the immune system and, being primary
      targets of HIV infection, they are used to measure disease progression and
      response to combination antiretroviral therapy (cART), alongside other
      parameters, in HIV/AIDS patients. The aim of this study was to determine the
      reference values of CD4(+) T cells in a student population that was HIV,
      hepatitis B virus (HBV) and hepatitis C virus (HCV) negative. After ethical
      clearance and informed consent, 500 subjects (mean age = 26 years) were
      recruited, of whom 56 (11.2%) had HIV, HBV or HCV and were excluded. Blood
      samples were collected from the remaining 444 subjects into vacutainer tubes and 
      analysed using the BD FACScount cytometer according to the manufacturer's
      instructions. Of the 444 subjects, 266 (59.9%) were male and 178 (40.1%) were
      female. The mean (+/- standard deviation) CD4(+) T cell count was 987
      cells/microL (+/- 336). The mean counts among males and females were 957
      cells/microL (+/- 306) and 991 cells/microL (+/- 340), respectively. Values of
      CD4(+) T cells ranged from 651 cells/microL to 1705 cells/microL. Subjects with
      higher CD4(+) T Cells were more likely to be female than male. There was no
      direct correlation between CD4(+) T cell values and age of the participants. Our 
      findings offer the first insight into the CD4(+) T cell reference values of a
      Nigerian student population and provide useful data that will guide future cART
      decisions and other immune-based therapies.
FAU - Pennap, Grace R
AU  - Pennap GR
AD  - Nasarawa State University, Keffi, Nasarawa State, Nigeria.
FAU - Adoga, Moses P
AU  - Adoga MP
FAU - Forbi, Joseph C
AU  - Forbi JC
FAU - Ojobo, Friday
AU  - Ojobo F
FAU - Agwale, Simon M
AU  - Agwale SM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110913
PL  - England
TA  - Trop Doct
JT  - Tropical doctor
JID - 1301706
SB  - IM
MH  - Adult
MH  - CD4 Lymphocyte Count/*standards
MH  - CD4-Positive T-Lymphocytes/*cytology/immunology
MH  - Female
MH  - Humans
MH  - Immunocompetence/*immunology
MH  - Male
MH  - Nigeria
MH  - Reference Values
MH  - Students/*statistics & numerical data
MH  - Universities
EDAT- 2011/09/15 06:00
MHDA- 2012/01/12 06:00
CRDT- 2011/09/15 06:00
PHST- 2011/09/15 06:00 [entrez]
PHST- 2011/09/15 06:00 [pubmed]
PHST- 2012/01/12 06:00 [medline]
AID - td.2011.110219 [pii]
AID - 10.1258/td.2011.110219 [doi]
PST - ppublish
SO  - Trop Doct. 2011 Oct;41(4):218-21. doi: 10.1258/td.2011.110219. Epub 2011 Sep 13.


PMID- 21914600
OWN - NLM
STAT- MEDLINE
DCOM- 20111028
LR  - 20110914
IS  - 1074-9357 (Print)
IS  - 1074-9357 (Linking)
VI  - 18
IP  - 4
DP  - 2011 Jul-Aug
TI  - Integrating design and communication in engineering education: a collaboration
      between Northwestern University and the Rehabilitation Institute of Chicago.
PG  - 361-6
LID - 10.1310/tsr1804-361 [doi]
AB  - The required course for freshmen in Northwestern University's engineering school 
      - a 2-quarter sequence called Engineering Design and Communication (EDC) - is
      noteworthy not only for its project-based focus on user-centered design, but also
      for its innovative integrated approach to teaching communication, teamwork, and
      ethics. Thanks to the collaboration between EDC faculty and staff at the
      Rehabilitation Institute of Chicago, EDC students, at the beginning of their
      education, experience the excitement of solving problems for real clients and
      users. At the same time, these authentic design projects offer an ideal setting
      for teaching students how to communicate effectively to different audiences and
      perform productively as team members and future leaders in engineering.
FAU - Hirsch, Penny L
AU  - Hirsch PL
AD  - The Writing Program, Northwestern University, Evanston, IL, USA.
FAU - Yarnoff, Charles
AU  - Yarnoff C
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - Top Stroke Rehabil
JT  - Topics in stroke rehabilitation
JID - 9439750
SB  - IM
MH  - *Cooperative Behavior
MH  - Engineering/*education
MH  - Equipment Design
MH  - Humans
MH  - Interdisciplinary Communication
MH  - Rehabilitation/*education
MH  - *Rehabilitation Centers/supply & distribution
MH  - Universities
EDAT- 2011/09/15 06:00
MHDA- 2011/10/29 06:00
CRDT- 2011/09/15 06:00
PHST- 2011/09/15 06:00 [entrez]
PHST- 2011/09/15 06:00 [pubmed]
PHST- 2011/10/29 06:00 [medline]
AID - T141J212844KR3NV [pii]
AID - 10.1310/tsr1804-361 [doi]
PST - ppublish
SO  - Top Stroke Rehabil. 2011 Jul-Aug;18(4):361-6. doi: 10.1310/tsr1804-361.


PMID- 21914313
OWN - NLM
STAT- MEDLINE
DCOM- 20120430
LR  - 20131121
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 91
IP  - 24
DP  - 2011 Jun 28
TI  - [A randomized controlled trial of rapid artificial cardiac pacing in thoracic
      endovascular aortic repair].
PG  - 1668-72
AB  - OBJECTIVE: To compare the safety, efficacy and their impact on stent graft
      positioning between rapid artificial cardiac pacing induced hypotension and
      sodium nitroprusside induced hypotension during thoracic endovascular aortic
      repair (TEVAR). METHODS: From September 2007 to February 2009, a randomized
      controlled trial as approved by the Ethics Committee of our hospital was
      conducted in 197 patients undergoing elective thoracic endovascular aortic repair
      of thoracic aortic dissection (n = 175) or aneurysm (n = 22). The patients were
      randomized into sodium nitroprusside group (n = 98) and rapid artificial cardiac 
      pacing group (n = 99). During the localization and deployment of stent graft,
      hypotension was induced by intravenous sodium nitroprusside or rapid artificial
      cardiac pacing. Hemodynamics, landing precision (deviation from planned placement
      site), duration of procedure, renal function, neurocognitive function, incidence 
      of endoleaks and paraplegia/hemiplegia were compared. RESULTS: Rapid artificial
      cardiac pacing was conducted without technical difficulty in all 99 patients. The
      level of hypotension (mm Hg, 1 mm Hg = 0.133 kPa) was most pronounced in the
      rapid artificial cardiac pacing group (47 +/- 5 vs 82 +/- 7, P = 0.003. Once
      rapid pacing ceased, blood pressure recovered more quickly to the preparing
      levels in the rapid artificial cardiac pacing group [(9 +/- 2) s vs (481 +/- 107)
      s, P < 0.01]. And the duration of procedure was also shorter in the rapid
      artificial cardiac pacing group [(94 +/- 16) min vs (103 +/- 24) min, P < 0.01]. 
      Moreover, precise positioning and deployment was observed in rapid artificial
      cardiac pacing group versus to the sodium nitroprusside group (P < 0.01). There
      was no difference in renal function and neurocognitive function before and after 
      the procedure in both groups. There was no difference in the incidences of
      endoleaks and paraplegia/hemiplegia between different groups (P > 0.05).
      CONCLUSION: As compared with sodium nitroprusside, rapid artificial cardiac
      pacing is safer in thoracic endovascular aortic repair. It shortens the
      endovascular procedure and enables more precise positioning and deployment of
      stent graft.
FAU - Huang, Wen-hui
AU  - Huang WH
AD  - Department of Cardiology, Guangdong Academy of Medical Sciences, Guangdong
      Cardiovascular Institute, Guangzhou, China.
FAU - He, Peng-cheng
AU  - He PC
FAU - Luo, Jian-fang
AU  - Luo JF
FAU - Liu, Yuan
AU  - Liu Y
FAU - Chen, Ji-yan
AU  - Chen JY
FAU - Tan, Ning
AU  - Tan N
FAU - Zhou, Ying-ling
AU  - Zhou YL
LA  - chi
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 169D1260KM (Nitroprusside)
SB  - IM
MH  - Aged
MH  - Aneurysm, Dissecting/surgery
MH  - *Aorta, Thoracic
MH  - Aortic Aneurysm, Thoracic/*surgery
MH  - Cardiac Pacing, Artificial/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nitroprusside/therapeutic use
MH  - *Stents
MH  - Treatment Outcome
EDAT- 2011/09/15 06:00
MHDA- 2012/05/01 06:00
CRDT- 2011/09/15 06:00
PHST- 2011/09/15 06:00 [entrez]
PHST- 2011/09/15 06:00 [pubmed]
PHST- 2012/05/01 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2011 Jun 28;91(24):1668-72.


PMID- 21914121
OWN - NLM
STAT- MEDLINE
DCOM- 20120621
LR  - 20151119
IS  - 1526-4637 (Electronic)
IS  - 1526-2375 (Linking)
VI  - 12
IP  - 9
DP  - 2011 Sep
TI  - A physician-driven solution--the Association for Medical Ethics, the Physician
      Payment Sunshine Act, and ethical challenges in pain medicine.
PG  - 1361-75
LID - 10.1111/j.1526-4637.2011.01217.x [doi]
AB  - The practice of contemporary pain medicine is laced with a number of significant 
      ethical challenges. Considerable difficulties include the overutilization of
      interventional procedures, the application of under-evidenced treatment
      modalities, and potentially superfluous opioid prescribing. As with many other
      fields in medicine, including orthopedic surgery, relationships with industry are
      both common and pervasive, and influence our medical practice through education, 
      publications, and research. This article highlights these ethical challenges and 
      broaches several physician-driven solutions: The Association for Medical Ethics, 
      the Physicians Payment Sunshine inspired by it, and other non-legislative reforms
      are discussed.
CI  - Wiley Periodicals, Inc.
FAU - Perret, Danielle
AU  - Perret D
AD  - Department of Anesthesiology & Perioperative Care, University of California,
      Irvine, School of Medicine, Orange, California, USA.
FAU - Rosen, Charles
AU  - Rosen C
LA  - eng
PT  - Editorial
PL  - England
TA  - Pain Med
JT  - Pain medicine (Malden, Mass.)
JID - 100894201
SB  - IM
MH  - Analgesia/*ethics/standards
MH  - California/epidemiology
MH  - Humans
MH  - Pain, Intractable/epidemiology/*therapy
MH  - Practice Patterns, Physicians'/*ethics/legislation & jurisprudence/trends
MH  - Reimbursement Mechanisms/*ethics/legislation & jurisprudence/trends
MH  - Societies, Medical/*ethics/legislation & jurisprudence/standards
EDAT- 2011/09/15 06:00
MHDA- 2012/06/22 06:00
CRDT- 2011/09/15 06:00
PHST- 2011/09/15 06:00 [entrez]
PHST- 2011/09/15 06:00 [pubmed]
PHST- 2012/06/22 06:00 [medline]
AID - 10.1111/j.1526-4637.2011.01217.x [doi]
PST - ppublish
SO  - Pain Med. 2011 Sep;12(9):1361-75. doi: 10.1111/j.1526-4637.2011.01217.x.


PMID- 21914114
OWN - NLM
STAT- MEDLINE
DCOM- 20120621
LR  - 20181201
IS  - 1526-4637 (Electronic)
IS  - 1526-2375 (Linking)
VI  - 12
IP  - 9
DP  - 2011 Sep
TI  - Pain, ethics, and public policy.
PG  - 1295-6
LID - 10.1111/j.1526-4637.2011.01219.x [doi]
FAU - Rich, Ben A
AU  - Rich BA
FAU - Dubois, Michel
AU  - Dubois M
LA  - eng
PT  - Editorial
PT  - Comment
PL  - England
TA  - Pain Med
JT  - Pain medicine (Malden, Mass.)
JID - 100894201
SB  - IM
CON - Pain Med. 2011 Sep;12(9):1376-84. PMID: 21810168
MH  - Chronic Pain/*therapy
MH  - Evidence-Based Medicine/*ethics
MH  - Health Services Accessibility/*ethics
MH  - Humans
MH  - Quality Assurance, Health Care/*ethics
EDAT- 2011/09/15 06:00
MHDA- 2012/06/22 06:00
CRDT- 2011/09/15 06:00
PHST- 2011/09/15 06:00 [entrez]
PHST- 2011/09/15 06:00 [pubmed]
PHST- 2012/06/22 06:00 [medline]
AID - 10.1111/j.1526-4637.2011.01219.x [doi]
PST - ppublish
SO  - Pain Med. 2011 Sep;12(9):1295-6. doi: 10.1111/j.1526-4637.2011.01219.x.


PMID- 21913614
OWN - NLM
STAT- MEDLINE
DCOM- 20111018
LR  - 20110914
IS  - 1086-5462 (Print)
IS  - 1086-5462 (Linking)
VI  - 94
IP  - 8
DP  - 2011 Aug
TI  - Prison ethics.
PG  - 222
FAU - Friedman, Joseph H
AU  - Friedman JH
AD  - joseph_friedman@brown.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Health R I
JT  - Medicine and health, Rhode Island
JID - 9603446
SB  - IM
MH  - Bioethical Issues
MH  - Donor Selection
MH  - *Ethics, Medical
MH  - Human Rights
MH  - Humans
MH  - Informed Consent/*ethics/legislation & jurisprudence
MH  - Mississippi
MH  - Prisoners
MH  - Prisons/*ethics
MH  - Social Responsibility
EDAT- 2011/09/15 06:00
MHDA- 2011/10/19 06:00
CRDT- 2011/09/15 06:00
PHST- 2011/09/15 06:00 [entrez]
PHST- 2011/09/15 06:00 [pubmed]
PHST- 2011/10/19 06:00 [medline]
PST - ppublish
SO  - Med Health R I. 2011 Aug;94(8):222.


PMID- 21913598
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111102
LR  - 20110914
IS  - 1053-816X (Print)
IS  - 1053-816X (Linking)
VI  - 31
IP  - 4
DP  - 2011 Jul-Aug
TI  - Care of the child with the desire to change genders--Part III: Male-to-female
      transition.
PG  - 236-41
AB  - This is Part II of a three-part series on children and young adults who desire to
      live as a gender different from which they were born. The series depicts the
      psychosocial, medical, and surgical components of transitioning from one gender
      to another. The medical and psychosocial issues of transgender change are
      complex, and ethical questions may be raised by those who would challenge these
      choices. Nurses will be best able to care for these patients with awareness of
      the multiple dimensions of these procedures and the ramifications of caring for
      them and their families.
FAU - Gibson, Bethany
AU  - Gibson B
AD  - Sonoma State University Rohnert Park, CA, USA.
FAU - Catlin, Anita J
AU  - Catlin AJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Urol Nurs
JT  - Urologic nursing
JID - 8812256
RPF - Pediatr Nurs. 2010 Sep-Oct;36(5):268-72. PMID: 21067080
EDAT- 2011/09/15 06:00
MHDA- 2011/09/15 06:01
CRDT- 2011/09/15 06:00
PHST- 2011/09/15 06:00 [entrez]
PHST- 2011/09/15 06:00 [pubmed]
PHST- 2011/09/15 06:01 [medline]
PST - ppublish
SO  - Urol Nurs. 2011 Jul-Aug;31(4):236-41.


PMID- 21913597
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111102
LR  - 20110914
IS  - 1053-816X (Print)
IS  - 1053-816X (Linking)
VI  - 31
IP  - 4
DP  - 2011 Jul-Aug
TI  - Care of the child with the desire to change genders--Part II: Female-to-male
      transition.
PG  - 230-5
AB  - This is Part II of a 3-part series on children and young adults who desire to
      live as a gender different from which they were born. The series depicts the
      psychosocial, medical, and surgical components of transitioning from one gender
      to another. The medical and psychosocial issues of transgender change are
      complex, and ethical questions may be raised by those who would challenge these
      choices. Nurses will be best able to care for these patients with awareness of
      the multiple dimensions of these procedures and the ramifications of caring for
      them and their families.
FAU - Gibson, Bethany
AU  - Gibson B
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Urol Nurs
JT  - Urologic nursing
JID - 8812256
RPF - Pediatr Nurs. 2010 Mar-Apr;36(2):112-7. PMID: 20476513
EDAT- 2011/09/15 06:00
MHDA- 2011/09/15 06:01
CRDT- 2011/09/15 06:00
PHST- 2011/09/15 06:00 [entrez]
PHST- 2011/09/15 06:00 [pubmed]
PHST- 2011/09/15 06:01 [medline]
PST - ppublish
SO  - Urol Nurs. 2011 Jul-Aug;31(4):230-5.


PMID- 21913596
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111102
LR  - 20110914
IS  - 1053-816X (Print)
IS  - 1053-816X (Linking)
VI  - 31
IP  - 4
DP  - 2011 Jul-Aug
TI  - Care of the child with the desire to change gender--Part I.
PG  - 222-9
AB  - This is Part I of a three-part series on children and young adults who desire to 
      live as a gender different from which they were born. The series depicts the
      psychosocial, medical, and surgical components of transitioning from one gender
      to another. The medical and psychosocial issues of transgender change are
      complex, and ethical questions may be raised by those who would challenge these
      choices. Nurses will be best able to care for these patients with awareness of
      the multiple dimensions of these procedures and the ramifications of caring for
      these children and their families.
FAU - Gibson, Bethany
AU  - Gibson B
AD  - Sonoma State University Rohnert Park, CA, USA.
FAU - Catlin, Anita J
AU  - Catlin AJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Urol Nurs
JT  - Urologic nursing
JID - 8812256
RPF - Pediatr Nurs. 2010 Jan-Feb;36(1):53-9. PMID: 20361446
EDAT- 2011/09/15 06:00
MHDA- 2011/09/15 06:01
CRDT- 2011/09/15 06:00
PHST- 2011/09/15 06:00 [entrez]
PHST- 2011/09/15 06:00 [pubmed]
PHST- 2011/09/15 06:01 [medline]
PST - ppublish
SO  - Urol Nurs. 2011 Jul-Aug;31(4):222-9.


PMID- 21913163
OWN - NLM
STAT- MEDLINE
DCOM- 20121019
LR  - 20120404
IS  - 1439-3824 (Electronic)
IS  - 0300-8630 (Linking)
VI  - 224
IP  - 2
DP  - 2012 Mar
TI  - Long term peritoneal dialysis in an anuric preterm infant - a futile treatment?
PG  - 76-9
LID - 10.1055/s-0031-1283142 [doi]
AB  - The primarily anuric very low birth weight infant (VLBWI) is an ethical challenge
      for the attending doctor as well as for the parents. Long term peritoneal
      dialysis (PD) might provide an acceptable way in treating a primarily anuric
      VLBWI prior to kidney transplantation without endangering the child's neurologic 
      development. We report a case of a VLBWI born at 30 weeks gestational age after
      anhydramnion for 5 weeks. Postnatally the neonate had persisting anuria and was
      successfully treated with peritonealdialysis for 31 months followed by
      hemodialysis for 12 months and eventually received a renal transplantion at the
      age of 43 months.
CI  - Georg Thieme Verlag KG Stuttgart . New York.
FAU - Faas, D
AU  - Faas D
AD  - General Pediatrics and Neonatology, Justus Liebig University Giessen,
      Feulgenstrasse 12, 35390 Giessen, Germany. dirk.faas@paediat.med.uni-giessen.de
FAU - Klauwer, D
AU  - Klauwer D
FAU - Klaus, G
AU  - Klaus G
FAU - Zerres, K
AU  - Zerres K
FAU - Neuhauser, C
AU  - Neuhauser C
FAU - Heckmann, M
AU  - Heckmann M
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20110912
PL  - Germany
TA  - Klin Padiatr
JT  - Klinische Padiatrie
JID - 0326144
SB  - IM
MH  - Anuria/*therapy
MH  - Child, Preschool
MH  - Combined Modality Therapy
MH  - Developmental Disabilities/diagnosis
MH  - Enteral Nutrition
MH  - Female
MH  - Follow-Up Studies
MH  - Graft Rejection/therapy
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Premature, Diseases/*therapy
MH  - *Infant, Very Low Birth Weight
MH  - Kidney Function Tests
MH  - Kidney Transplantation
MH  - Long-Term Care
MH  - *Medical Futility
MH  - Peritoneal Dialysis/*methods
MH  - Pregnancy
MH  - Renal Dialysis
MH  - Resuscitation
EDAT- 2011/09/14 06:00
MHDA- 2012/10/20 06:00
CRDT- 2011/09/14 06:00
PHST- 2011/09/14 06:00 [entrez]
PHST- 2011/09/14 06:00 [pubmed]
PHST- 2012/10/20 06:00 [medline]
AID - 10.1055/s-0031-1283142 [doi]
PST - ppublish
SO  - Klin Padiatr. 2012 Mar;224(2):76-9. doi: 10.1055/s-0031-1283142. Epub 2011 Sep
      12.


PMID- 21912979
OWN - NLM
STAT- MEDLINE
DCOM- 20120316
LR  - 20211020
IS  - 1573-7330 (Electronic)
IS  - 1058-0468 (Linking)
VI  - 28
IP  - 11
DP  - 2011 Nov
TI  - A legal-ethical analysis of reproductive endocrinologists' right to refuse
      ovulation induction to patients with diminished ovarian reserve.
PG  - 1105-9
LID - 10.1007/s10815-011-9636-3 [doi]
AB  - PURPOSE: Review of the legal and ethical basis for reproductive endocrinologists 
      to refuse ovulation induction to patients with diminished ovarian reserve.
      METHODS: The Lexis-Nexis search engine was used to perform a legal review
      pertaining to refusal of treatment. Ethical opinions of medical organizations
      were also reviewed. RESULTS: Federal antidiscrimination laws provide legal
      recourse for patients with diminished ovarian reserve who are denied ovulation
      induction. However, the same laws also permit refusal of care when there is bona 
      fide medical justification to decline services. In addition, the codes of ethics 
      for relevant professional organizations support physicians' decisions to refuse
      treatment when treatment is futile. CONCLUSION: Although it is ethically and
      legally permissible to deny ovulation induction to patients with diminished
      ovarian reserve when medically justified, refusal may invite retaliatory
      litigation. Counseling remains a cornerstone in directing these patients to
      options with more potential for success, such as donor eggs and adoption.
FAU - Karipcin, Fethiye Sinem
AU  - Karipcin FS
AD  - Department of Obstetrics & Gynecology, The University of Texas Medical Branch,
      Galveston, TX 77555-0587, USA. fskaripc@utmb.edu
FAU - Hossain, Amjad
AU  - Hossain A
FAU - Phelps, John Y
AU  - Phelps JY
LA  - eng
PT  - Journal Article
DEP - 20110913
PL  - Netherlands
TA  - J Assist Reprod Genet
JT  - Journal of assisted reproduction and genetics
JID - 9206495
SB  - IM
MH  - Adoption/legislation & jurisprudence
MH  - *Endocrinology/ethics/legislation & jurisprudence
MH  - Ethical Analysis
MH  - Female
MH  - Humans
MH  - Ovulation Induction/*ethics
MH  - Reproductive Rights/*ethics/*legislation & jurisprudence
MH  - Tissue Donors/legislation & jurisprudence
MH  - Workforce
PMC - PMC3224169
EDAT- 2011/09/14 06:00
MHDA- 2012/03/17 06:00
CRDT- 2011/09/14 06:00
PHST- 2011/06/16 00:00 [received]
PHST- 2011/08/31 00:00 [accepted]
PHST- 2011/09/14 06:00 [entrez]
PHST- 2011/09/14 06:00 [pubmed]
PHST- 2012/03/17 06:00 [medline]
AID - 10.1007/s10815-011-9636-3 [doi]
PST - ppublish
SO  - J Assist Reprod Genet. 2011 Nov;28(11):1105-9. doi: 10.1007/s10815-011-9636-3.
      Epub 2011 Sep 13.


PMID- 21911672
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111027
LR  - 20150417
IS  - 1538-3601 (Electronic)
IS  - 0003-9950 (Linking)
VI  - 129
IP  - 9
DP  - 2011 Sep
TI  - How medical school oaths and professional codes of ethics affect physicians'
      practice.
PG  - 1221-2
LID - 10.1001/archophthalmol.2011.258 [doi]
FAU - Bartley, George B
AU  - Bartley GB
AD  - Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA.
      gbartley@mayo.edu
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Arch Ophthalmol
JT  - Archives of ophthalmology (Chicago, Ill. : 1960)
JID - 7706534
CON - Arch Intern Med. 2011 Mar 14;171(5):469-71. PMID: 21403046
EDAT- 2011/09/14 06:00
MHDA- 2011/09/14 06:01
CRDT- 2011/09/14 06:00
PHST- 2011/09/14 06:00 [entrez]
PHST- 2011/09/14 06:00 [pubmed]
PHST- 2011/09/14 06:01 [medline]
AID - 129/9/1221 [pii]
AID - 10.1001/archophthalmol.2011.258 [doi]
PST - ppublish
SO  - Arch Ophthalmol. 2011 Sep;129(9):1221-2. doi: 10.1001/archophthalmol.2011.258.


PMID- 21911322
OWN - NLM
STAT- MEDLINE
DCOM- 20120402
LR  - 20220331
IS  - 1308-5735 (Electronic)
VI  - 3
IP  - 3
DP  - 2011
TI  - Current concepts in disorders of sexual development.
PG  - 105-14
LID - 10.4274/jcrpe.v3i3.22 [doi]
AB  - Disorders of sex development (DSD) with or without ambiguous genitalia require
      medical attention to reach a definite diagnosis. Advances in identification of
      molecular causes of abnormal sex, heightened awareness of ethical issues and this
      necessitated a re-evaluation of nomenclature. The term DSD was proposed for
      congenital conditions in which chromosomal, gonadal or anatomical sex is
      atypical. In general, factors influencing sex determination are transcriptional
      regulators, whereas factors important for sex differentiation are secreted
      hormones and their receptors. The current intense debate on the management of
      patients with intersexuality and related conditions focus on four major issues:
      1) aetiological diagnosis, 2) assignment of gender, 3) indication for and timing 
      of genital surgery, 4) the disclosure of medical information to the patient and
      his/her parents. The psychological and social implications of gender assignment
      require a multidisciplinary approach and a team which includes ageneticist,
      neonatologist, endocrinologist, gynaecologist, psychiatrist, surgeon and a social
      worker. Each patient should be evaluated individually by multidisciplinary
      approach.
FAU - Ocal, Gonul
AU  - Ocal G
AD  - Ankara University School of Medicine, Department of Pediatric Endocrinology,
      Ankara, Turkey. gonulocal@gmail.com
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Turkey
TA  - J Clin Res Pediatr Endocrinol
JT  - Journal of clinical research in pediatric endocrinology
JID - 101519456
SB  - IM
MH  - Animals
MH  - Disorders of Sex Development/diagnosis/genetics/*physiopathology/therapy
MH  - Female
MH  - Genitalia/*abnormalities
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - Sex Determination Analysis/methods
PMC - PMC3184510
EDAT- 2011/09/14 06:00
MHDA- 2012/04/03 06:00
CRDT- 2011/09/14 06:00
PHST- 2011/09/14 06:00 [entrez]
PHST- 2011/09/14 06:00 [pubmed]
PHST- 2012/04/03 06:00 [medline]
AID - 10.4274/jcrpe.v3i3.22 [doi]
PST - ppublish
SO  - J Clin Res Pediatr Endocrinol. 2011;3(3):105-14. doi: 10.4274/jcrpe.v3i3.22.


PMID- 21911141
OWN - NLM
STAT- MEDLINE
DCOM- 20120110
LR  - 20110913
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 43
IP  - 7
DP  - 2011 Sep
TI  - Ethical selection on liver transplantation and abandoning treatment for
      hepatocellular carcinoma in China.
PG  - 2656-9
LID - 10.1016/j.transproceed.2011.06.062 [doi]
AB  - Orthotopic liver transplantation (OLT) has evolved in China over three decades,
      emerging as the mainstay treatment for hepatocellular carcinoma (HCC). Some
      Chinese transplantation centers have begun offering OLT for selected patients
      with HCC exceeding Milan criteria. However, this still remains a controversial
      subject. In this article, we have weighed arguments for and against OLT for
      advanced HCC. Meanwhile, the development of OLT for HCC in China has raised
      problems, mainly focused on ethical and moral concerns. Postmodern philosophy and
      ethics, particularly the life value theory, shall be the theoretical support to
      the concept of abandoning treatment. In China, ethical selection for OLT and
      abandoning treatment for HCC must be made justly and prudently.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Xia, D
AU  - Xia D
AD  - Department of General Surgery, Affiliated Hospital of Luzhou Medical College,
      Luzhou, China.
FAU - Zuo, H-Q
AU  - Zuo HQ
FAU - Quan, Y
AU  - Quan Y
FAU - Dong, H-L
AU  - Dong HL
FAU - Xu, L
AU  - Xu L
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - Carcinoma, Hepatocellular/*surgery
MH  - China
MH  - *Ethics, Medical
MH  - Humans
MH  - Liver Neoplasms/*surgery
MH  - *Liver Transplantation
MH  - Patient Selection/*ethics
EDAT- 2011/09/14 06:00
MHDA- 2012/01/11 06:00
CRDT- 2011/09/14 06:00
PHST- 2011/05/09 00:00 [received]
PHST- 2011/06/16 00:00 [accepted]
PHST- 2011/09/14 06:00 [entrez]
PHST- 2011/09/14 06:00 [pubmed]
PHST- 2012/01/11 06:00 [medline]
AID - S0041-1345(11)00915-8 [pii]
AID - 10.1016/j.transproceed.2011.06.062 [doi]
PST - ppublish
SO  - Transplant Proc. 2011 Sep;43(7):2656-9. doi: 10.1016/j.transproceed.2011.06.062.


PMID- 21910958
OWN - NLM
STAT- MEDLINE
DCOM- 20120221
LR  - 20190516
IS  - 2242-3982 (Electronic)
IS  - 1239-9736 (Linking)
VI  - 70
IP  - 4
DP  - 2011 Sep
TI  - Review of procedures for approval of health studies in northern Canada.
PG  - 354-62
LID - 1116 [pii]
AB  - OBJECTIVES: This article describes the review processes required for research
      being conducted in Canada's 3 northern territories. When conducting research
      involving human subjects in northern Canada, researchers must go through a 2-step
      process by submitting protocols to both their university or hospital ethics
      review boards as well as to northern research institutions. Canada's northern
      territorial governments have requirements for attaining licensure before any
      research can be conducted. METHODS: A document review was the method used to
      gather data, and an Internet search of the literature and documents was conducted
      to gather information. RESULTS: Generally, university and hospital-based ethics
      review boards have been concerned with the rights of individuals in research.
      Northern Canadian research protocols require review by territorial government
      institutions and communities with respect to community rights. CONCLUSIONS: The 3
      territorial governments of northern Canada take the concept of community and
      individual participation in research seriously and have enacted processes so that
      opportunities for such approaches to research are ensured.
FAU - George, M Anne
AU  - George MA
AD  - Faculty of Medicine, University of British Columbia, Prince George, British
      Columbia, V2N 4Z9, Canada. anne.george@phsa.ca
LA  - eng
PT  - Journal Article
DEP - 20110913
PL  - United States
TA  - Int J Circumpolar Health
JT  - International journal of circumpolar health
JID - 9713056
SB  - IM
MH  - *Community Participation
MH  - Ethics Committees, Research/*standards
MH  - Health Services Research/legislation & jurisprudence/*methods
MH  - Humans
MH  - Indians, North American
MH  - Inuits
MH  - Northwest Territories
MH  - *Research Subjects
EDAT- 2011/09/14 06:00
MHDA- 2012/02/22 06:00
CRDT- 2011/09/14 06:00
PHST- 2011/09/14 06:00 [entrez]
PHST- 2011/09/14 06:00 [pubmed]
PHST- 2012/02/22 06:00 [medline]
AID - 1116 [pii]
AID - 10.3402/ijch.v70i4.17838 [doi]
PST - ppublish
SO  - Int J Circumpolar Health. 2011 Sep;70(4):354-62. doi: 10.3402/ijch.v70i4.17838.
      Epub 2011 Sep 13.


PMID- 21909861
OWN - NLM
STAT- MEDLINE
DCOM- 20120325
LR  - 20211020
IS  - 1432-2218 (Electronic)
IS  - 0930-2794 (Linking)
VI  - 26
IP  - 2
DP  - 2012 Feb
TI  - Does hypocapnia before and during carbon dioxide insufflation attenuate the
      hemodynamic changes during laparoscopic cholecystectomy?
PG  - 391-7
LID - 10.1007/s00464-011-1884-x [doi]
AB  - BACKGROUND: Hypocapnia before and during carbon dioxide (CO(2)) insufflation for 
      laparoscopic cholecystectomy may reduce the adverse hemodynamic responses.
      METHODS: After ethical approval, 100 patients scheduled for laparoscopic
      cholecystectomy were ventilated using a tidal volume of 8 ml/kg, an
      inspiration:expiration ratio of 1:2.5, and a positive end-expiratory pressure
      (PEEP) of 5 cm H(2)O. At 15 min before CO(2) insufflation, the patients were
      randomly allocated into two groups of 50 patients each. For the normocapnia
      group, the respiratory rate (RR) was adjusted to maintain arterial CO(2) tension 
      (PaCO(2)) at 35 to 45 mmHg. For the hypocapnia group, the RR was adjusted to
      maintain PaCO(2) at 30 to 35 mmHg. Anesthesia was maintained with sevoflurane 2% 
      to 2.5% in 40% air oxygen and rocuronium. Hemodynamic variables, PaCO(2),
      end-tidal CO(2) tension (EtCO(2)), arterial-to-end-tidal CO(2) (Pa-ETCO(2))
      gradient, and RR were recorded. RESULTS: Compared with the control group, the use
      of hypocapnia before and during pneumoperitoneum was associated with
      significantly lower arterial blood pressures, lower PaCO(2) and EtCO(2) values, a
      higher Pa-ETCO(2), a higher RR (p < 0.001), and less need for supplemental doses 
      of fentanyl and labetalol. CONCLUSION: The authors conclude that the use of
      hypocapnia before and during CO(2) insufflation is effective in attenuating
      increases in blood pressure after CO(2) pneumoperitoneum during anesthesia for
      laparoscopic cholecystectomy.
FAU - El-Tahan, Mohamed R
AU  - El-Tahan MR
AD  - Department of Anaesthesia and Surgical ICU, College of Medicine, University of
      Dammam, The Coastal Area of Al-Rakah, Dammam, P.O. 40289, Al Khubar, 31952, Saudi
      Arabia. mohamedrefaateltahan@yahoo.com
FAU - Al Dossary, Noha D
AU  - Al Dossary ND
FAU - El Emam, Hatem
AU  - El Emam H
FAU - Diab, Douaa G
AU  - Diab DG
FAU - Al'Saflan, Abdulhadi
AU  - Al'Saflan A
FAU - Zien, Haitham
AU  - Zien H
FAU - Al Ahmadey, Mona
AU  - Al Ahmadey M
FAU - Deria, Afrah
AU  - Deria A
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20110910
PL  - Germany
TA  - Surg Endosc
JT  - Surgical endoscopy
JID - 8806653
RN  - 142M471B3J (Carbon Dioxide)
SB  - IM
MH  - Adult
MH  - Anesthesia, General/methods
MH  - Blood Pressure/physiology
MH  - Carbon Dioxide/*blood
MH  - Cholecystectomy, Laparoscopic/*methods
MH  - Double-Blind Method
MH  - Female
MH  - Heart Rate/physiology
MH  - Hemodynamics/*physiology
MH  - Humans
MH  - Insufflation/*methods
MH  - Male
MH  - Partial Pressure
MH  - Pneumoperitoneum, Artificial/methods
MH  - Prospective Studies
MH  - Respiration, Artificial/methods
MH  - Respiratory Rate/physiology
EDAT- 2011/09/13 06:00
MHDA- 2012/03/27 06:00
CRDT- 2011/09/13 06:00
PHST- 2011/03/17 00:00 [received]
PHST- 2011/08/04 00:00 [accepted]
PHST- 2011/09/13 06:00 [entrez]
PHST- 2011/09/13 06:00 [pubmed]
PHST- 2012/03/27 06:00 [medline]
AID - 10.1007/s00464-011-1884-x [doi]
PST - ppublish
SO  - Surg Endosc. 2012 Feb;26(2):391-7. doi: 10.1007/s00464-011-1884-x. Epub 2011 Sep 
      10.


PMID- 21909829
OWN - NLM
STAT- MEDLINE
DCOM- 20120312
LR  - 20211020
IS  - 1878-7479 (Electronic)
IS  - 1878-7479 (Linking)
VI  - 8
IP  - 4
DP  - 2011 Oct
TI  - Cell therapy for spinal cord injury by neural stem/progenitor cells derived from 
      iPS/ES cells.
PG  - 668-76
LID - 10.1007/s13311-011-0063-z [doi]
AB  - Reports of functional recovery from spinal cord injury after the transplantation 
      of rat fetus-derived neural stem cells and embryonic stem cells has raised great 
      expectations for the successful clinical use of stem cell transplantation
      therapy. However, the ethical issues involved in destroying human embryos or
      fertilized oocytes to obtain stem cells have been a major obstacle to developing 
      clinically useful stem cell sources, and the transplantation of stem cells
      isolated from other human embryonic tissues has not yet been developed for use in
      clinical applications. Recently, induced pluripotent stem cells, which can serve 
      as a source of cells for autologous transplantation, have been attracting a great
      deal of attention as a clinically viable alternative to stem cells obtained
      directly from tissues. In this review, we outline the neural induction of mouse
      embryonic stem cells and induced pluripotent stem cells, their therapeutic
      efficacy in spinal cord injury, and their safety in vivo.
FAU - Tsuji, Osahiko
AU  - Tsuji O
AD  - Department of Orthopaedic Surgery, School of Medicine, Keio University, 35
      Shinanomachi, Shinjuku, Tokyo 160-8582, Japan.
FAU - Miura, Kyoko
AU  - Miura K
FAU - Fujiyoshi, Kanehiro
AU  - Fujiyoshi K
FAU - Momoshima, Suketaka
AU  - Momoshima S
FAU - Nakamura, Masaya
AU  - Nakamura M
FAU - Okano, Hideyuki
AU  - Okano H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Neurotherapeutics
JT  - Neurotherapeutics : the journal of the American Society for Experimental
      NeuroTherapeutics
JID - 101290381
SB  - IM
MH  - Animals
MH  - Cell Differentiation
MH  - Embryonic Stem Cells/physiology
MH  - Humans
MH  - Mice
MH  - Neural Stem Cells/*physiology
MH  - Rats
MH  - Spinal Cord Injuries/*surgery
MH  - Stem Cell Transplantation/*methods
PMC - PMC3250290
EDAT- 2011/09/13 06:00
MHDA- 2012/03/13 06:00
CRDT- 2011/09/13 06:00
PHST- 2011/09/13 06:00 [entrez]
PHST- 2011/09/13 06:00 [pubmed]
PHST- 2012/03/13 06:00 [medline]
AID - 10.1007/s13311-011-0063-z [doi]
PST - ppublish
SO  - Neurotherapeutics. 2011 Oct;8(4):668-76. doi: 10.1007/s13311-011-0063-z.


PMID- 21909698
OWN - NLM
STAT- MEDLINE
DCOM- 20120516
LR  - 20211020
IS  - 1432-1262 (Electronic)
IS  - 0179-1958 (Linking)
VI  - 27
IP  - 2
DP  - 2012 Feb
TI  - Randomised multicentre trial of circular stapling devices.
PG  - 227-32
LID - 10.1007/s00384-011-1307-4 [doi]
AB  - PURPOSE: In a register study, the risk of anastomotic leakage correlated to the
      choice of circular stapling device with a 4% difference between the two brands
      used. Based on those data, a randomised multicentre study was started to explore 
      the risk of an anastomotic leakage based upon the surgical device. METHODS:
      Patients above 18 years with a rectal cancer, able to give informed consent, and 
      scheduled for an anterior resection were eligible for the study. Perioperative
      randomisation was to Ethicon PROXIMATE ILS or Autosuture Premium Plus CEEA.
      Anastomotic leakage was defined as a clinically manifest leak. RESULTS: Five
      hundred twenty-nine patients were randomised (58% male). A leak occurred in 8.3%.
      The anastomoses created by PROXIMATE ILS leaked in 25/265 (9.4%) anastomoses, and
      the Premium Plus CEEA leaked in 19/260 (7.3%), p = .419. CONCLUSION: No
      difference in the leak rate could be revealed. Several centres replaced one of
      the staplers by a new product, and the study was ended before the stipulated
      number of patients was reached. In the future, surgical devices may have to prove
      superiority in randomised trials or be monitored in quality registers before they
      can be introduced into day to day surgical practice. The study was registered at 
      ClinicalTrials.gov: NCT00399009.
FAU - Folkesson, Joakim
AU  - Folkesson J
AD  - Department of Surgery, Uppsala University Hospital, 751 85, Uppsala, Sweden.
      joakim.folkesson@surgsci.uu.se
FAU - Brown, Steven S R
AU  - Brown SS
FAU - Gunnarsson, Ulf
AU  - Gunnarsson U
FAU - Pahlman, Lars
AU  - Pahlman L
LA  - eng
SI  - ClinicalTrials.gov/NCT00399009
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
DEP - 20110910
PL  - Germany
TA  - Int J Colorectal Dis
JT  - International journal of colorectal disease
JID - 8607899
SB  - IM
MH  - Aged
MH  - Anastomotic Leak/etiology
MH  - Body Mass Index
MH  - Female
MH  - Humans
MH  - Male
MH  - Multivariate Analysis
MH  - Risk Factors
MH  - *Surgical Staplers/adverse effects
EDAT- 2011/09/13 06:00
MHDA- 2012/05/17 06:00
CRDT- 2011/09/13 06:00
PHST- 2011/08/30 00:00 [accepted]
PHST- 2011/09/13 06:00 [entrez]
PHST- 2011/09/13 06:00 [pubmed]
PHST- 2012/05/17 06:00 [medline]
AID - 10.1007/s00384-011-1307-4 [doi]
PST - ppublish
SO  - Int J Colorectal Dis. 2012 Feb;27(2):227-32. doi: 10.1007/s00384-011-1307-4. Epub
      2011 Sep 10.


PMID- 21909690
OWN - NLM
STAT- MEDLINE
DCOM- 20120522
LR  - 20211020
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 23
IP  - 4
DP  - 2011 Dec
TI  - Defense mechanisms in ethics consultation.
PG  - 269-79
LID - 10.1007/s10730-011-9165-6 [doi]
AB  - While there is no denying the relevance of ethical knowledge and analytical and
      cognitive skills in ethics consultation, such knowledge and skills can be
      overemphasized. They can be effectively put into practice only by an ethics
      consultant, who has a broad range of other skills, including interpretive and
      communicative capacities as well as the capacity effectively to address the
      psychosocial needs of patients, family members, and healthcare professionals in
      the context of an ethics consultation case. In this paper, I discuss how emotion 
      can play an important interpretive role in clinical ethics consultation and why
      attention to the role of defense mechanisms can be helpful. I concentrate on
      defense mechanisms, arguing first, that the presence of these mechanisms is
      understandable given the emotional stresses and communicative occlusions that
      occur between the families of patients and critical care professionals in the
      circumstances of critical care; second, that identifying these mechanisms is
      essential for interpreting and managing how these factors influence the way that 
      the "facts" of the case are understood by family members; and, third, that
      effectively addressing these mechanisms is an important component for effectively
      doing ethics consultation. Recognizing defense mechanisms, understanding how and 
      why they operate, and knowing how to deal with these defense mechanisms when they
      pose problems for communication or decision making are thus essential
      prerequisites for effective ethics consultation, especially in critical care.
FAU - Agich, George J
AU  - Agich GJ
AD  - Department of Social Medicine, National Taiwan University, Taipei, Taiwan.
      agichg@bgsu.edu
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - Communication
MH  - Critical Care
MH  - *Defense Mechanisms
MH  - *Ethics Consultation
MH  - Humans
MH  - Taiwan
EDAT- 2011/09/13 06:00
MHDA- 2012/05/23 06:00
CRDT- 2011/09/13 06:00
PHST- 2011/09/13 06:00 [entrez]
PHST- 2011/09/13 06:00 [pubmed]
PHST- 2012/05/23 06:00 [medline]
AID - 10.1007/s10730-011-9165-6 [doi]
PST - ppublish
SO  - HEC Forum. 2011 Dec;23(4):269-79. doi: 10.1007/s10730-011-9165-6.


PMID- 21909689
OWN - NLM
STAT- MEDLINE
DCOM- 20120206
LR  - 20211020
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 23
IP  - 3
DP  - 2011 Sep
TI  - Core competencies for health care ethics consultants: in search of professional
      status in a post-modern world.
PG  - 129-45
LID - 10.1007/s10730-011-9167-4 [doi]
AB  - The American Society for Bioethics and the Humanities (ASBH) issued its Core
      Competencies for Health Care Ethics Consultation just as it is becoming ever
      clearer that secular ethics is intractably plural and without foundations in any 
      reality that is not a social-historical construction (ASBH Core Competencies for 
      Health Care Ethics Consultation, 2nd edn. American Society for Bioethics and
      Humanities, Glenview, IL, 2011). Core Competencies fails to recognize that the
      ethics of health care ethics consultants is not ethics in the usual sense of a
      morally canonical ethics. Its ethics is the ethics established at law and in
      enforceable health care public policy in a particular jurisdiction. Its
      normativity is a legal normativity, so that the wrongness of violating this
      ethics is simply the legal penalties involved and the likelihood of their being
      imposed. That the ethics of ethics consultation is that ethics legally
      established accounts for the circumstance that the major role of hospital ethics 
      consultants is as quasi-lawyers giving legal advice, aiding in risk management,
      and engaging in mediation. It also indicates why this collage of roles has
      succeeded so well. This article shows how moral philosophy as it was reborn in
      the 13th century West led to the ethics of modernity and then finally to the
      ethics of hospital ethics consultation. It provides a brief history of the
      emergence of an ethics that is after morality. Against this background, the
      significance of Core Competencies must be critically reconsidered.
FAU - Engelhardt, H Tristram Jr
AU  - Engelhardt HT Jr
AD  - Department of Philosophy, Rice University, Houston, TX, 77251-1892, USA.
      htengelh@rice.edu
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - Bioethics/history/trends
MH  - Ethicists/*standards
MH  - *Ethics, Clinical/history
MH  - Europe
MH  - *Guidelines as Topic
MH  - History, 18th Century
MH  - History, 19th Century
MH  - History, 20th Century
MH  - History, Medieval
MH  - Hospitals/ethics
MH  - Humans
MH  - *Morals
MH  - *Professional Competence
MH  - Professional Role
MH  - Risk Management/ethics
MH  - *Social Change
MH  - United States
EDAT- 2011/09/13 06:00
MHDA- 2012/02/07 06:00
CRDT- 2011/09/13 06:00
PHST- 2011/09/13 06:00 [entrez]
PHST- 2011/09/13 06:00 [pubmed]
PHST- 2012/02/07 06:00 [medline]
AID - 10.1007/s10730-011-9167-4 [doi]
PST - ppublish
SO  - HEC Forum. 2011 Sep;23(3):129-45. doi: 10.1007/s10730-011-9167-4.


PMID- 21909330
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1664-1078 (Electronic)
IS  - 1664-1078 (Linking)
VI  - 2
DP  - 2011
TI  - Best practices for allocating appropriate credit and responsibility to authors of
      multi-authored articles.
PG  - 196
LID - 10.3389/fpsyg.2011.00196 [doi]
AB  - Working in multidisciplinary teams has become a common feature of modern research
      processes. This situation inevitably leads to the question of how to decide on
      who to acknowledge as authors of a multi-authored publication. The question is
      gaining pertinence, since individual scientists' publication records are playing 
      an increasingly important role in their professional success. At worst,
      discussions about authorship allocation might lead to a serious conflict among
      coworkers that could even endanger the successful completion of a whole research 
      project. Surprisingly, there does not seem to be any discussion on the issue of
      ethical standards for authorship is the field of Cognitive Science at the moment.
      In this short review I address the problem by characterizing modern challenges to
      a fair system for allocating authorship. I also offer a list of best practice
      principles and recommendations for determining authors in multi-authored
      publications on the basis of a review of existing standards.
FAU - Eggert, Lucas D
AU  - Eggert LD
AD  - Institute of Cognitive Science, University of Osnabruck Germany.
LA  - eng
PT  - Journal Article
DEP - 20110901
PL  - Switzerland
TA  - Front Psychol
JT  - Frontiers in psychology
JID - 101550902
PMC - PMC3164109
OTO - NOTNLM
OT  - authorship
OT  - contributorship
OT  - responsible conduct of research
OT  - scientific publishing
EDAT- 2011/09/13 06:00
MHDA- 2011/09/13 06:01
CRDT- 2011/09/13 06:00
PHST- 2011/05/17 00:00 [received]
PHST- 2011/08/04 00:00 [accepted]
PHST- 2011/09/13 06:00 [entrez]
PHST- 2011/09/13 06:00 [pubmed]
PHST- 2011/09/13 06:01 [medline]
AID - 10.3389/fpsyg.2011.00196 [doi]
PST - epublish
SO  - Front Psychol. 2011 Sep 1;2:196. doi: 10.3389/fpsyg.2011.00196. eCollection 2011.


PMID- 21909149
OWN - NLM
STAT- MEDLINE
DCOM- 20111025
LR  - 20151119
IS  - 1117-1936 (Print)
VI  - 18
IP  - 3
DP  - 2011 Sep
TI  - Examination malpractice in our medical schools: prevalence and import on
      tomorrow's doctors.
PG  - 191-6
AB  - UNLABELLED: AIMS AND OBJECTIVES. The objective of this paper is to estimate the
      prevalence of examination malpractice among medical students; its import on
      medical education and future doctors. MATERIALS AND METHODS: Structured
      questionnaires were administered to consenting medical students of participating 
      four medical colleges in Nigeria. Data was collated and analysed using SPSS
      version 11. RESULTS: Three hundred and eighty two students responded. There were 
      210 males and 172 females (M: F-1.2:1); age range 19-45 years, mean 24.86 +/- SD.
      Majority 304(79.6%) were in the 5th and final years. At secondary and tertiary
      levels, 67(18.1%) and 79(22.2%) were respectively involved in cheating. Mode of
      cheating included seeking examination materials, 10(2.6%); copying answers
      between examination rooms, 18(4.8%); copying assignments, 290(77.7%) and copying 
      laboratory results 206(56.6%). Clinical examinations not performed were described
      as "normal" by 206(56.6%). Motivation for cheating included previous failures and
      escape punishment in 6(3.3%) and 31(10.4%) respectively. While 46(12.8%) tried to
      induce lecturers to change grades, 97(25.8%) would not inform the authority if
      they suspected that examination leaked. CONCLUSION: Examination malpractice in
      High schools and Tertiary institutions also includes the medical students.
      Educating pupils from the elementary schools on effects of cheating, inclusion of
      this practice in the medical curriculum as part of Medical Ethics and
      Institutional culture of Integrity among doctors are recommended. Stiffer
      punishment for offenders would reduce the practice among the students.
FAU - Aderounmu, A O A
AU  - Aderounmu AO
AD  - Dept. of Surgery, Ladoke Akintola University of Technology, College of Health
      Sciences, PMB 4000, Ogbomoso, Oyo State. Nigeria. atilola27@yahoo.com
FAU - Olaitan, P B
AU  - Olaitan PB
FAU - Kolawole, I K
AU  - Kolawole IK
FAU - Dairo, M D
AU  - Dairo MD
FAU - Oluwadiya, K S
AU  - Oluwadiya KS
FAU - Okeke, L I
AU  - Okeke LI
FAU - Salako, A A
AU  - Salako AA
LA  - eng
PT  - Journal Article
PL  - Nigeria
TA  - Niger Postgrad Med J
JT  - The Nigerian postgraduate medical journal
JID - 9613595
SB  - IM
MH  - Adult
MH  - Clinical Competence
MH  - *Deception
MH  - *Education, Medical, Undergraduate/methods/trends
MH  - Educational Measurement/*standards
MH  - Female
MH  - Humans
MH  - Male
MH  - *Malpractice
MH  - Middle Aged
MH  - Nigeria
MH  - Prevalence
MH  - Students, Medical/psychology/*statistics & numerical data
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2011/09/13 06:00
MHDA- 2011/10/26 06:00
CRDT- 2011/09/13 06:00
PHST- 2011/09/13 06:00 [entrez]
PHST- 2011/09/13 06:00 [pubmed]
PHST- 2011/10/26 06:00 [medline]
PST - ppublish
SO  - Niger Postgrad Med J. 2011 Sep;18(3):191-6.


PMID- 21908835
OWN - NLM
STAT- MEDLINE
DCOM- 20120103
LR  - 20110912
IS  - 1522-1229 (Electronic)
IS  - 1043-4046 (Linking)
VI  - 35
IP  - 3
DP  - 2011 Sep
TI  - Video laboratories for the teaching and learning of professional ethics in
      exercise physiology curricula.
PG  - 264-9
LID - 10.1152/advan.00122.2010 [doi]
AB  - Student researchers in physiology courses often interact with human subjects in
      classroom research but may be unfamiliar with the professional ethics of
      experimenter-subject interactions. This communication describes experiences
      related to an interactive video used in exercise science and general biology
      courses to help students become aware of, sensitive to, and comfortable with
      implementing professional ethics into their own thinking and behavior as
      researchers before entering the laboratory. The activity consisted of a filmed
      exercise physiology experiment complemented with interactive question sheets
      followed by small- and large-group discussion and culminating with individual
      student reflections. Student written responses from multiple courses indicated
      that students were able to 1) identify and consider the ethics of
      experimenter-subject interactions from the movie, 2) generalize broader ideas of 
      professional ethics from those observations, and 3) consider their observations
      in terms of future experiments they would be conducting personally and how they
      should interact with human subjects. A majority of students indicated a positive 
      reaction to the video and identified specific aspects they appreciated. It is
      hoped that this report will encourage other instructors to consider the use of
      interactive videos in the teaching and learning of professional ethics related to
      their courses.
FAU - Senchina, David S
AU  - Senchina DS
AD  - Biology Department, Drake University, Des Moines, Iowa, USA. dssenchina@drake.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Adv Physiol Educ
JT  - Advances in physiology education
JID - 100913944
SB  - IM
MH  - *Curriculum
MH  - *Ethics, Professional
MH  - *Exercise
MH  - Humans
MH  - *Learning
MH  - Physiology/*education
MH  - *Teaching
MH  - *Videotape Recording
EDAT- 2011/09/13 06:00
MHDA- 2012/01/04 06:00
CRDT- 2011/09/13 06:00
PHST- 2011/09/13 06:00 [entrez]
PHST- 2011/09/13 06:00 [pubmed]
PHST- 2012/01/04 06:00 [medline]
AID - 35/3/264 [pii]
AID - 10.1152/advan.00122.2010 [doi]
PST - ppublish
SO  - Adv Physiol Educ. 2011 Sep;35(3):264-9. doi: 10.1152/advan.00122.2010.


PMID- 21908759
OWN - NLM
STAT- MEDLINE
DCOM- 20120123
LR  - 20110912
IS  - 1943-3662 (Electronic)
IS  - 1093-6793 (Linking)
VI  - 39
IP  - 3
DP  - 2011
TI  - www.mydrugdealer.com: Ethics and legal implications of Internet-based access to
      substances of abuse.
PG  - 407-11
AB  - The Internet has increasingly become an intrinsic part of everyday life, offering
      countless possibilities for education, services, recreation, and more. In fact,
      an entire virtual life within the digitalized World Wide Web is possible and
      common among many Internet users. Today's psychiatrists must therefore
      incorporate this dimension of human life into clinical practice, to achieve an
      adequate assessment of the tools and risks available to the patient. We focus on 
      the Internet as a portal for the trade of and access to substances of abuse. We
      review the legal regulations that may inform care and standards of practice and
      analyze the difficulties that arise in assessment and monitoring of the current
      situation. We consider the potential impact of Internet-based narcotics trade on 
      addiction morbidities and the practice of clinical psychiatry, as well as on the 
      potential legal implications that the forensic expert may face.
FAU - Klein, Carolina A
AU  - Klein CA
AD  - Saint Elizabeths Hospital, Department of Mental Health, Washington, DC, USA.
      carolina.klein@gmail.com
FAU - Kandel, Surendra
AU  - Kandel S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Acad Psychiatry Law
JT  - The journal of the American Academy of Psychiatry and the Law
JID - 9708963
RN  - 0 (Psychotropic Drugs)
SB  - IM
MH  - Commerce/*ethics/*legislation & jurisprudence
MH  - Forensic Psychiatry/legislation & jurisprudence
MH  - Humans
MH  - Internet/*ethics/*legislation & jurisprudence
MH  - Psychotropic Drugs/*supply & distribution
MH  - Substance-Related Disorders
EDAT- 2011/09/13 06:00
MHDA- 2012/01/24 06:00
CRDT- 2011/09/13 06:00
PHST- 2011/09/13 06:00 [entrez]
PHST- 2011/09/13 06:00 [pubmed]
PHST- 2012/01/24 06:00 [medline]
AID - 39/3/407 [pii]
PST - ppublish
SO  - J Am Acad Psychiatry Law. 2011;39(3):407-11.


PMID- 21908755
OWN - NLM
STAT- MEDLINE
DCOM- 20120123
LR  - 20181201
IS  - 1943-3662 (Electronic)
IS  - 1093-6793 (Linking)
VI  - 39
IP  - 3
DP  - 2011
TI  - Clinicians imagine a patient's view: Rating disclosures of confidential
      information.
PG  - 379-86
AB  - Consent to disclosure of confidential information is a cornerstone of the
      clinician-patient relationship; however, changes in the legal, regulatory, and
      technological landscape affecting patient confidentiality have brought increasing
      conflict between ethics-based commitments and the realities of practice. In this 
      pilot study, 119 mental-health clinicians completed a questionnaire that measured
      levels of disapproval of disclosures of confidential information to various third
      parties. Clinicians were asked to respond as though they were patients whose
      information was to be disclosed. Clinicians, taking a patient's perspective, most
      disapproved of disclosures to anyone who wanted the information and to entities
      that marketed pharmaceutical, medical, or other products. They were progressively
      less uncomfortable with disclosures to family members, for educational use
      without consent but with de-identification, to insurance companies, to
      pharmacists, to journals, for educational purposes in training other clinicians, 
      and for research. They were least disapproving of disclosures to other
      clinicians. Based on this initial study of clinicians taking a patient's
      perspective, clinicians will do well to inform patients about disclosure
      practices at least as fully as they themselves would want to be informed.
FAU - Spruiell, Graham Lindley
AU  - Spruiell GL
AD  - Beth Israel Deaconess Medical Center, Department of Psychiatry, 330 Brookline
      Avenue, Boston, MA 02215, USA. gls@analysis.com
FAU - Hauser, Mark J
AU  - Hauser MJ
FAU - Commons, Michael Lamport
AU  - Commons ML
FAU - Drogin, Eric Y
AU  - Drogin EY
LA  - eng
PT  - Journal Article
PT  - Legal Case
PL  - United States
TA  - J Am Acad Psychiatry Law
JT  - The journal of the American Academy of Psychiatry and the Law
JID - 9708963
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - *Confidentiality
MH  - *Disclosure
MH  - Female
MH  - Humans
MH  - Male
MH  - Mental Health Services
MH  - Middle Aged
MH  - Pilot Projects
MH  - Surveys and Questionnaires
EDAT- 2011/09/13 06:00
MHDA- 2012/01/24 06:00
CRDT- 2011/09/13 06:00
PHST- 2011/09/13 06:00 [entrez]
PHST- 2011/09/13 06:00 [pubmed]
PHST- 2012/01/24 06:00 [medline]
AID - 39/3/379 [pii]
PST - ppublish
SO  - J Am Acad Psychiatry Law. 2011;39(3):379-86.


PMID- 21908752
OWN - NLM
STAT- MEDLINE
DCOM- 20120123
LR  - 20110912
IS  - 1943-3662 (Electronic)
IS  - 1093-6793 (Linking)
VI  - 39
IP  - 3
DP  - 2011
TI  - Oral performance, identity, and representation in forensic psychiatry.
PG  - 352-63
AB  - The specialty of forensic psychiatry is advancing in practice and in its
      scholarship. One task for an evolving discipline is to define and master the
      nature of its work. In this article we assert that the work of testifying in
      court is more than the sharing of specialized knowledge. It is performance.
      Anthropology, religious studies, political science, and psychology (among other
      disciplines) have investigated elements of face-to-face human interaction set
      within ritual and credentialed it as worthy of attention and belief. Such is the 
      nature of expert testimony within forensic psychiatry. This is our position, but 
      we also consider well-founded concerns about the ethics of highlighting oral
      performance. These topics emphasize the need for the discipline to recognize the 
      unique nature of testimony, to master the work and control standards that assure 
      excellence and ethics-based practice.
FAU - Griffith, Ezra E H
AU  - Griffith EE
AD  - Department of Psychiatry, Yale University School of Medicine, 300 George Street, 
      Suite 901, New Haven, CT 06511, USA. ezra.griffith@yale.edu
FAU - Baranoski, Madelon
AU  - Baranoski M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Acad Psychiatry Law
JT  - The journal of the American Academy of Psychiatry and the Law
JID - 9708963
SB  - IM
CIN - J Am Acad Psychiatry Law. 2011;39(3):364-9. PMID: 21908753
MH  - Communication
MH  - *Expert Testimony/standards
MH  - *Forensic Psychiatry
MH  - Humans
MH  - Interpersonal Relations
EDAT- 2011/09/13 06:00
MHDA- 2012/01/24 06:00
CRDT- 2011/09/13 06:00
PHST- 2011/09/13 06:00 [entrez]
PHST- 2011/09/13 06:00 [pubmed]
PHST- 2012/01/24 06:00 [medline]
AID - 39/3/352 [pii]
PST - ppublish
SO  - J Am Acad Psychiatry Law. 2011;39(3):352-63.


PMID- 21908751
OWN - NLM
STAT- MEDLINE
DCOM- 20120123
LR  - 20181201
IS  - 1943-3662 (Electronic)
IS  - 1093-6793 (Linking)
VI  - 39
IP  - 3
DP  - 2011
TI  - Commentary: Moving The Journal forward.
PG  - 345-51
AB  - Breaches of ethics are prevalent in biomedical publishing. Kapoor and colleagues 
      identify several of the practical and ethics dilemmas that they have encountered 
      in editing The Journal of the American Academy of Psychiatry and the Law.
      Biomedical publishing ethics is continually evolving, with discrepant practice
      among different publications. Publication ethics apply to authors, editors, peer 
      reviewers, journal publishers or owners, and their respective institutions. The
      Journal and the American Academy of Psychiatry and the Law (AAPL) would be
      enhanced by better formulating and elucidating its authorship requirements and
      relevant disclosures, both in print and online. The Journal could then serve as a
      leader in this arena.
FAU - Wettstein, Robert M
AU  - Wettstein RM
AD  - University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
      wettsteins@aol.com
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - J Am Acad Psychiatry Law
JT  - The journal of the American Academy of Psychiatry and the Law
JID - 9708963
SB  - IM
CON - J Am Acad Psychiatry Law. 2011;39(3):332-41. PMID: 21908749
MH  - *Forensic Psychiatry
MH  - Humans
MH  - Publishing/*ethics
EDAT- 2011/09/13 06:00
MHDA- 2012/01/24 06:00
CRDT- 2011/09/13 06:00
PHST- 2011/09/13 06:00 [entrez]
PHST- 2011/09/13 06:00 [pubmed]
PHST- 2012/01/24 06:00 [medline]
AID - 39/3/345 [pii]
PST - ppublish
SO  - J Am Acad Psychiatry Law. 2011;39(3):345-51.


PMID- 21908750
OWN - NLM
STAT- MEDLINE
DCOM- 20120123
LR  - 20181201
IS  - 1943-3662 (Electronic)
IS  - 1093-6793 (Linking)
VI  - 39
IP  - 3
DP  - 2011
TI  - Commentary: A new chapter for forensic ethics.
PG  - 342-4
AB  - In response to a new ethics framework for forensic publishing, this commentary
      invites speculation on how the framework will develop to incorporate the theories
      of its authors. Although medical ethics may now be an established cornerstone for
      forensic practice, it is in the more novel theories of cultural narrative,
      compassion, and robust professionalism that this new ethic will find its full
      expression. The commentary argues that it is only through approaches that
      integrate such multiple perspectives that publishing will join professionalism in
      protecting the ethics values that remain vulnerable in forensic practice.
FAU - Candilis, Philip J
AU  - Candilis PJ
AD  - Department of Psychiatry, University of Massachusetts Medical School, 55 Lake
      Avenue North, Worcester, MA 01655, USA. philip.candilis@umassmed.edu
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - J Am Acad Psychiatry Law
JT  - The journal of the American Academy of Psychiatry and the Law
JID - 9708963
SB  - IM
CON - J Am Acad Psychiatry Law. 2011;39(3):332-41. PMID: 21908749
MH  - *Forensic Psychiatry
MH  - Humans
MH  - Publishing/*ethics
EDAT- 2011/09/13 06:00
MHDA- 2012/01/24 06:00
CRDT- 2011/09/13 06:00
PHST- 2011/09/13 06:00 [entrez]
PHST- 2011/09/13 06:00 [pubmed]
PHST- 2012/01/24 06:00 [medline]
AID - 39/3/342 [pii]
PST - ppublish
SO  - J Am Acad Psychiatry Law. 2011;39(3):342-4.


PMID- 21908749
OWN - NLM
STAT- MEDLINE
DCOM- 20120123
LR  - 20110912
IS  - 1943-3662 (Electronic)
IS  - 1093-6793 (Linking)
VI  - 39
IP  - 3
DP  - 2011
TI  - Ethics in forensic psychiatry publishing.
PG  - 332-41
AB  - Several organizations have developed guidelines to help authors and editors of
      medical journals negotiate ethics dilemmas in publishing, but very little is
      known about how these guidelines translate to the context of forensic psychiatry.
      In this article, we explore the important topic of ethics in forensic psychiatry 
      publishing. First, we review the historical development of ethics principles in
      medical and psychiatric publishing. We then analyze eight ethics dilemmas that
      have arisen in the publication of The Journal of the American Academy of
      Psychiatry and the Law (The Journal) from 2000 to 2009, including disputes about 
      authorship, conflict of interest, redundant publication, bias in peer reviewers, 
      confidentiality in case reports, and others. We identify ethics principles that
      were relevant to the dilemmas and discuss how they were resolved by the editors
      of The Journal. We conclude by using the principles identified in the practical
      resolution of ethics dilemmas to derive a conceptual foundation for ethics in
      forensic psychiatry publishing.
FAU - Kapoor, Reena
AU  - Kapoor R
AD  - Department of Psychiatry, Yale University School of Medicine, New Haven, CT
      06519, USA. reena.kapoor@yale.edu
FAU - Young, John L
AU  - Young JL
FAU - Coleman, Jacquelyn T
AU  - Coleman JT
FAU - Norko, Michael A
AU  - Norko MA
FAU - Griffith, Ezra E H
AU  - Griffith EE
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Acad Psychiatry Law
JT  - The journal of the American Academy of Psychiatry and the Law
JID - 9708963
SB  - IM
CIN - J Am Acad Psychiatry Law. 2011;39(3):342-4. PMID: 21908750
CIN - J Am Acad Psychiatry Law. 2011;39(3):345-51. PMID: 21908751
MH  - Authorship
MH  - Editorial Policies
MH  - Ethics Committees, Research
MH  - *Forensic Psychiatry
MH  - Humans
MH  - Plagiarism
MH  - Prejudice
MH  - Publishing/*ethics
MH  - Scientific Misconduct/ethics
EDAT- 2011/09/13 06:00
MHDA- 2012/01/24 06:00
CRDT- 2011/09/13 06:00
PHST- 2011/09/13 06:00 [entrez]
PHST- 2011/09/13 06:00 [pubmed]
PHST- 2012/01/24 06:00 [medline]
AID - 39/3/332 [pii]
PST - ppublish
SO  - J Am Acad Psychiatry Law. 2011;39(3):332-41.


PMID- 21907844
OWN - NLM
STAT- MEDLINE
DCOM- 20110921
LR  - 20150616
IS  - 1474-547X (Electronic)
IS  - 0140-6736 (Linking)
VI  - 378
IP  - 9795
DP  - 2011 Sep 10
TI  - Ethical behaviour in clinical research--a lesson from the past.
PG  - 962
LID - 10.1016/S0140-6736(11)61433-5 [doi]
FAU - The Lancet
AU  - The Lancet
LA  - eng
PT  - Editorial
PT  - Historical Article
PL  - England
TA  - Lancet
JT  - Lancet (London, England)
JID - 2985213R
SB  - IM
MH  - Clinical Trials as Topic/ethics/*history
MH  - Ethics, Research/*history
MH  - Guatemala
MH  - History, 20th Century
MH  - Humans
MH  - Indiana
MH  - Sexually Transmitted Diseases, Bacterial/history
EDAT- 2011/09/13 06:00
MHDA- 2011/09/22 06:00
CRDT- 2011/09/13 06:00
PHST- 2011/09/13 06:00 [entrez]
PHST- 2011/09/13 06:00 [pubmed]
PHST- 2011/09/22 06:00 [medline]
AID - S0140-6736(11)61433-5 [pii]
AID - 10.1016/S0140-6736(11)61433-5 [doi]
PST - ppublish
SO  - Lancet. 2011 Sep 10;378(9795):962. doi: 10.1016/S0140-6736(11)61433-5.


PMID- 21907452
OWN - NLM
STAT- MEDLINE
DCOM- 20120413
LR  - 20121218
IS  - 1097-6760 (Electronic)
IS  - 0196-0644 (Linking)
VI  - 59
IP  - 3
DP  - 2012 Mar
TI  - Altering the standard of care in disasters--unnecessary and dangerous.
PG  - 191-5
LID - 10.1016/j.annemergmed.2011.07.037 [doi]
AB  - After September 11, 2001, the United States began examining approaches to the
      delivery of medical care during disasters when demand exceeds available
      resources. One seemingly popular option is the creation of "crisis" or "altered" 
      care standards meant to reduce the legal standard or duty of care for medical
      responders. However, evidence supporting the need for reduced care standards is
      lacking. Concern for liability exists but it is not evidence based. The actual
      risk for litigation is minimal, according to experience with multiple disasters
      during the last 15 years. Even if a lower legal standard or duty of care were to 
      be adopted, it is unlikely this would reduce the risk of liability because
      violation of this lower standard could still result in an allegation of
      malpractice. Creating algorithms to equitably and rationally allocate scarce
      resources is necessary and appropriate, but altering the legal standard of care
      will not contribute to this process. Rather than inhibiting the creation of these
      protocols, the current legal standard of care helps guarantee that disaster
      policies are created in an ethical and transparent manner. Adoption of a lower
      legal care standard would encourage implementation of less effective approaches
      and could undermine the impetus to constantly improve the care of disaster
      victims. Once lowering the legal standard of care becomes accepted practice, it
      becomes unclear what will prevent this process from moving downward indefinitely.
      The most rational approach buttressed by evidence to date supports maintaining
      the current legal standard of care defined by the actions of reasonably prudent
      physicians under the same or similar circumstances.
CI  - Copyright (c) 2011 American College of Emergency Physicians. Published by Mosby, 
      Inc. All rights reserved.
FAU - Schultz, Carl H
AU  - Schultz CH
AD  - Center for Disaster Medical Sciences, Department of Emergency Medicine,
      University of California Irvine School of Medicine, Orange, CA, USA.
      schultzc@uci.edu
FAU - Annas, George J
AU  - Annas GJ
LA  - eng
PT  - Journal Article
DEP - 20110909
PL  - United States
TA  - Ann Emerg Med
JT  - Annals of emergency medicine
JID - 8002646
SB  - IM
CIN - Ann Emerg Med. 2012 Mar;59(3):237-8. PMID: 22340807
CIN - Ann Emerg Med. 2012 May;59(5):443-4; author reply 444-5. PMID: 22525537
CIN - Ann Emerg Med. 2012 Nov;60(5):669-70; author reply 670-1. PMID: 23089095
MH  - Disaster Medicine/*standards
MH  - *Disasters
MH  - Humans
MH  - *Quality of Health Care/standards
MH  - Resource Allocation/methods/standards
MH  - United States
EDAT- 2011/09/13 06:00
MHDA- 2012/04/14 06:00
CRDT- 2011/09/13 06:00
PHST- 2011/03/08 00:00 [received]
PHST- 2011/07/02 00:00 [revised]
PHST- 2011/07/29 00:00 [accepted]
PHST- 2011/09/13 06:00 [entrez]
PHST- 2011/09/13 06:00 [pubmed]
PHST- 2012/04/14 06:00 [medline]
AID - S0196-0644(11)01409-0 [pii]
AID - 10.1016/j.annemergmed.2011.07.037 [doi]
PST - ppublish
SO  - Ann Emerg Med. 2012 Mar;59(3):191-5. doi: 10.1016/j.annemergmed.2011.07.037. Epub
      2011 Sep 9.


PMID- 21907080
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20181201
IS  - 1545-7206 (Electronic)
IS  - 0033-3182 (Linking)
VI  - 52
IP  - 5
DP  - 2011 Sep-Oct
TI  - Response to: "Do-not-resuscitate orders in suicidal patients: clinical, ethical, 
      and legal dilemmas".
PG  - 498
LID - 10.1016/j.psym.2011.01.020 [doi]
FAU - Alfandre, David
AU  - Alfandre D
LA  - eng
PT  - Letter
PT  - Comment
PL  - England
TA  - Psychosomatics
JT  - Psychosomatics
JID - 0376506
SB  - IM
CON - Psychosomatics. 2010 Jul-Aug;51(4):277-82. PMID: 20587754
MH  - Humans
MH  - *Mental Disorders
MH  - Resuscitation Orders/*ethics/*legislation & jurisprudence
MH  - Suicide/*ethics/*legislation & jurisprudence
EDAT- 2011/09/13 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/09/13 06:00
PHST- 2011/09/13 06:00 [entrez]
PHST- 2011/09/13 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - S0033-3182(11)00066-1 [pii]
AID - 10.1016/j.psym.2011.01.020 [doi]
PST - ppublish
SO  - Psychosomatics. 2011 Sep-Oct;52(5):498. doi: 10.1016/j.psym.2011.01.020.


PMID- 21907060
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20220129
IS  - 1545-7206 (Electronic)
IS  - 0033-3182 (Linking)
VI  - 52
IP  - 5
DP  - 2011 Sep-Oct
TI  - Thoughts of death and suicide reported by cancer patients who endorsed the
      "suicidal thoughts" item of the PHQ-9 during routine screening for depression.
PG  - 424-7
LID - 10.1016/j.psym.2011.02.003 [doi]
AB  - BACKGROUND: Patients with serious medical illnesses, such as cancer, are at
      increased risk of suicide but are also often facing death. The Patient Health
      Questionnaire-9 (PHQ-9) is widely used to screen patients for depression. It
      includes an item that asks about thoughts of death and hurting yourself (Item-9).
      OBJECTIVE: To describe the nature of thoughts of death and suicide reported in
      clinical interviews carried out to further assess suicidal ideation of cancer
      outpatients who had endorsed the "suicidal thoughts item" (Item-9) of the PHQ-9
      during routine depression screening. METHOD: Secondary analysis of anonymized
      service data (with ethical approval) derived from the routine clinical
      administration of self-report questionnaires and telephone interviews to
      outpatients attending a Cancer Centre in the UK. RESULTS: Complete data were
      available on 330/463 (71%) of patients who had endorsed Item-9. In a subsequent
      structured telephone interview, approximately one-third of these patients denied 
      any thoughts that they would be better off dead, another third acknowledged
      having thoughts that they would be better off dead, but not of suicide, and the
      remaining third reported clear thoughts of committing suicide. CONCLUSION: Only
      one-third of cancer outpatients who endorse the "suicidal thoughts item" of the
      PHQ-9 report suicidal thoughts at a subsequent interview. Services planning to
      set up depression screening with the PHQ-9 need to carefully consider the
      relative benefits and burden to their service and patients of including Item-9
      and interviewing all those who endorse it.
CI  - Copyright (c) 2011 The Academy of Psychosomatic Medicine. Published by Elsevier
      Inc. All rights reserved.
FAU - Walker, Jane
AU  - Walker J
AD  - Psychological Medicine Research, Edinburgh Cancer Research Centre, School of
      Molecular and Clinical Medicine, University of Edinburgh, Scotland, UK.
      jane.walker@ed.ac.uk
FAU - Hansen, Christian Holm
AU  - Hansen CH
FAU - Butcher, Isabella
AU  - Butcher I
FAU - Sharma, Neelom
AU  - Sharma N
FAU - Wall, Lucy
AU  - Wall L
FAU - Murray, Gordon
AU  - Murray G
FAU - Sharpe, Michael
AU  - Sharpe M
LA  - eng
GR  - G0800803/MRC_/Medical Research Council/United Kingdom
GR  - CRUK_/Cancer Research UK/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Psychosomatics
JT  - Psychosomatics
JID - 0376506
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Attitude to Death
MH  - Depression/*diagnosis/psychology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/*psychology
MH  - *Psychiatric Status Rating Scales
MH  - *Suicidal Ideation
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2011/09/13 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/09/13 06:00
PHST- 2010/11/29 00:00 [received]
PHST- 2011/02/01 00:00 [revised]
PHST- 2011/02/01 00:00 [accepted]
PHST- 2011/09/13 06:00 [entrez]
PHST- 2011/09/13 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - S0033-3182(11)00128-9 [pii]
AID - 10.1016/j.psym.2011.02.003 [doi]
PST - ppublish
SO  - Psychosomatics. 2011 Sep-Oct;52(5):424-7. doi: 10.1016/j.psym.2011.02.003.


PMID- 21906895
OWN - NLM
STAT- MEDLINE
DCOM- 20130322
LR  - 20121003
IS  - 1872-7727 (Electronic)
IS  - 0720-048X (Linking)
VI  - 81
IP  - 11
DP  - 2012 Nov
TI  - Diffusion tensor imaging (DTI) of desmoid tumours in familial adenomatous
      polyposis: initial experience.
PG  - 3646-51
LID - 10.1016/j.ejrad.2011.08.003 [doi]
LID - S0720-048X(11)00647-4 [pii]
AB  - PURPOSE: To assess the feasibility of diffusion tensor imaging (DTI) of desmoid
      tumours in familial adenomatous polyposis (FAP). MATERIALS AND METHODS: Following
      ethical approval and informed consent, FAP patients with desmoids underwent DTI. 
      Fractional anisotropy (FA), relative anisotropy (RA) and apparent diffusion
      coefficient (ADC) were compared to control muscle using Mann-Whitney test; and to
      tumour site and signal intensity using one way analysis of variance (ANOVA).
      Imaging was repeated after 1 year. RESULTS: 15 desmoids (6 intra-abdominal; 6
      abdominal wall, 3 extra-abdominal; size range: 1.6-22.9 cm) were evaluated in 9
      patients. DTI was successful in 12/15 desmoid tumours. Median (range) of RA, FA
      and ADC were 0.23x10(-3) mm2/s (0.17-0.26); 0.27x10(-3) mm2/s (0.21-0.31); and
      1.65x10(-3) mm2/s (1.39-1.91) for desmoids, significantly different from muscle: 
      0.27x10(-3) mm2/s (0.23-0.40), 0.32x10(-3) mm2/s (0.28-0.46), and 1.45x10(-3)
      mm2/s (0.92-1.63) (p=0.0001, p=0.0001, p=0.0016, respectively). There was no
      difference in RA, FA or ADC between tumour sites, or signal intensity (p>0.05).
      One year later, 2 patients had died. Tumour increased in size in 1 patient
      (+61%). DTI quantification was possible in only 8/13 tumours. FA, RA and ADC were
      not significantly different from baseline (p=0.77, 0.71 and 0.34, respectively). 
      CONCLUSIONS: Assessment of water diffusion has the potential to provide insight
      into tumour microstructure and is feasible in desmoids. Desmoid tumours
      demonstrate anisotropy but diffusion is less restricted and less directional than
      in muscle.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Bhandari, Santosh
AU  - Bhandari S
AD  - Polyposis Registry, St. Mark's Hospital, Watford Road, Harrow, Middlesex HA1 3UJ,
      UK. s.bhandari10@imperial.ac.uk
FAU - Sinha, Ashish
AU  - Sinha A
FAU - Tam, Emily
AU  - Tam E
FAU - Stirling, J James
AU  - Stirling JJ
FAU - Simcock, Ian
AU  - Simcock I
FAU - Clark, Sue
AU  - Clark S
FAU - Goh, Vicky
AU  - Goh V
LA  - eng
PT  - Journal Article
DEP - 20110908
PL  - Ireland
TA  - Eur J Radiol
JT  - European journal of radiology
JID - 8106411
RN  - Desmoid disease, hereditary
SB  - IM
MH  - Abdominal Neoplasms/*complications/*pathology
MH  - Adenomatous Polyposis Coli/*complications/*pathology
MH  - Adult
MH  - Diffusion Magnetic Resonance Imaging/*methods
MH  - Female
MH  - Fibromatosis, Aggressive/*complications/*pathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Young Adult
EDAT- 2011/09/13 06:00
MHDA- 2013/03/23 06:00
CRDT- 2011/09/13 06:00
PHST- 2011/06/27 00:00 [received]
PHST- 2011/08/04 00:00 [revised]
PHST- 2011/08/14 00:00 [accepted]
PHST- 2011/09/13 06:00 [entrez]
PHST- 2011/09/13 06:00 [pubmed]
PHST- 2013/03/23 06:00 [medline]
AID - S0720-048X(11)00647-4 [pii]
AID - 10.1016/j.ejrad.2011.08.003 [doi]
PST - ppublish
SO  - Eur J Radiol. 2012 Nov;81(11):3646-51. doi: 10.1016/j.ejrad.2011.08.003. Epub
      2011 Sep 8.


PMID- 21906890
OWN - NLM
STAT- MEDLINE
DCOM- 20120307
LR  - 20140812
IS  - 1773-0430 (Electronic)
IS  - 0150-9918 (Linking)
VI  - 40
IP  - 7
DP  - 2011 Nov
TI  - [Induction of labour and breech presentation: experience of a French maternity
      ward].
PG  - 668-74
LID - 10.1016/j.jgyn.2011.03.008 [doi]
AB  - INTRODUCTION: For a few years, we can notice a progressive increase in the
      practice of systematic caesarean delivery as far as breech delivery is concerned.
      This is true notably since the publication of Hannah's "Term Breech Trial" in
      2000 which recommends systematic caesarean delivery in the case of breech
      presentation. But the conclusions of this North-American study are questionable, 
      knowing that French practice is often quite different from Hannah's study.
      OBJECTIVE: In the maternity ward of the French hospital Robert-Debre, Paris,
      vaginal delivery may be authorized as far as breech presentation is concerned if 
      defined obstetrical criteria are met. Labour can be induced when a maternal or
      fetal indication exists. In the following study, we tried to assess our practice.
      STUDY DESIGN: Our retrospective study included 624 patients with a breech
      presentation, of which 501 within the group of spontaneous labour (group 1) and
      123 within the group of cervical preparation and induced labour (group 2), for
      the period going from 1 January 2000 to 31 December 2008. RESULTS: The results do
      comfort our attitude since they show equivalent results in terms of delivery mode
      and neonatal issues between breech presentations with spontaneous labour on one
      hand, and with labour induced by cervical maturation on the other hand.
      CONCLUSION: The primary objective of this study was to evaluate an unusual
      operating practice in a well-trained level 3 obstetrical team. The results do
      comfort our attitude since they show equivalent results in terms of delivery mode
      and neonatal issues between breech presentations with spontaneous labour on one
      hand, and with labour induced by cervical maturation on the other hand. It seems 
      however difficult to extrapolate our results and apply them to usual practice due
      to the lack of power of a retrospective and non-randomized study. Setting up a
      randomized and prospective study seems however difficult because of the medical
      and ethical problems it would raise.
CI  - Copyright (c) 2011 Elsevier Masson SAS. All rights reserved.
FAU - Marzouk, P
AU  - Marzouk P
AD  - Service de gynecologie obstetrique, departement de perinatalogie, hopital
      Robert-Debre, 48, boulevard Serurier, 75019 Paris, France.
FAU - Arnaud, E
AU  - Arnaud E
FAU - Oury, J-F
AU  - Oury JF
FAU - Sibony, O
AU  - Sibony O
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Induction du travail et presentation du siege : experience de la maternite de
      l'hopital Robert-Debre, Paris.
DEP - 20110908
PL  - France
TA  - J Gynecol Obstet Biol Reprod (Paris)
JT  - Journal de gynecologie, obstetrique et biologie de la reproduction
JID - 0322206
SB  - IM
MH  - Adult
MH  - Breech Presentation/*epidemiology
MH  - Female
MH  - France
MH  - *Hospitals, Maternity
MH  - Humans
MH  - Labor, Induced/*statistics & numerical data
MH  - Pregnancy
MH  - Pregnancy Outcome
MH  - Retrospective Studies
MH  - Young Adult
EDAT- 2011/09/13 06:00
MHDA- 2012/03/08 06:00
CRDT- 2011/09/13 06:00
PHST- 2011/01/12 00:00 [received]
PHST- 2011/03/18 00:00 [revised]
PHST- 2011/03/21 00:00 [accepted]
PHST- 2011/09/13 06:00 [entrez]
PHST- 2011/09/13 06:00 [pubmed]
PHST- 2012/03/08 06:00 [medline]
AID - S0368-2315(11)00178-5 [pii]
AID - 10.1016/j.jgyn.2011.03.008 [doi]
PST - ppublish
SO  - J Gynecol Obstet Biol Reprod (Paris). 2011 Nov;40(7):668-74. doi:
      10.1016/j.jgyn.2011.03.008. Epub 2011 Sep 8.


PMID- 21906458
OWN - NLM
STAT- MEDLINE
DCOM- 20131029
LR  - 20110912
IS  - 1000-503X (Print)
IS  - 1000-503X (Linking)
VI  - 33
IP  - 4
DP  - 2011 Aug
TI  - [Research advances in induced pluripotent stem cells].
PG  - 456-61
LID - 10.3881/j.issn.1000-503X.2011.04.022 [doi]
AB  - Differentiated somatic cells can be directly reprogrammed into induced
      pluripotent stem (iPS) cells in vitro. Similarly to embryonic stem (ES) cells,
      iPS cells have pluripotency to differentiate into all cell types and capability
      to self-renew themselves indefinitely. Without immune rejection and ethical
      issues, patient-specific iPS cells promise to be an ideal tool for regenerative
      medicine, drug screening, and toxicity testing.
FAU - Jiang, Xing-ran
AU  - Jiang XR
AD  - State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, CAMS and
      PUMC, Beijing, China.
FAU - Lu, Shi-xin
AU  - Lu SX
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - China
TA  - Zhongguo Yi Xue Ke Xue Yuan Xue Bao
JT  - Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
JID - 8006230
SB  - IM
MH  - Humans
MH  - *Induced Pluripotent Stem Cells
EDAT- 2011/09/13 06:00
MHDA- 2013/10/30 06:00
CRDT- 2011/09/13 06:00
PHST- 2011/09/13 06:00 [entrez]
PHST- 2011/09/13 06:00 [pubmed]
PHST- 2013/10/30 06:00 [medline]
AID - 10.3881/j.issn.1000-503X.2011.04.022 [doi]
PST - ppublish
SO  - Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2011 Aug;33(4):456-61. doi:
      10.3881/j.issn.1000-503X.2011.04.022.


PMID- 21906335
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 2110-5820 (Electronic)
IS  - 2110-5820 (Linking)
VI  - 1
IP  - 1
DP  - 2011 Apr 13
TI  - Protecting vulnerable research subjects in critical care trials: enhancing the
      informed consent process and recommendations for safeguards.
PG  - 8
LID - 10.1186/2110-5820-1-8 [doi]
AB  - Although critically ill patients represent a vulnerable group of individuals,
      guidelines in research ethics assert that ethically acceptable research may
      proceed with such vulnerable subjects if additional safeguards are in place to
      minimize the risk of harm and exploitation. Such safeguards include the proper
      obtainment of informed consent that avoids the presence of the therapeutic
      misconception and the assessment of decisional capacity in critically ill
      patients recruited for research. Also discussed in this review are additional
      safeguards for such vulnerable subjects, as well as the issues involved with
      proxy consent. Heightened awareness to principles of ethics and provision of
      additional safeguards to enhance protections of vulnerable subjects would help to
      maintain the public trust in the research endeavor.
FAU - Silverman, Henry
AU  - Silverman H
AD  - University of Maryland School of Medicine, 110 South Paca Street; 2nd floor,
      Baltimore, Maryland, USA 21201, USA. hsilverm@medicine.umaryland.edu.
LA  - eng
PT  - Journal Article
DEP - 20110413
PL  - Germany
TA  - Ann Intensive Care
JT  - Annals of intensive care
JID - 101562873
PMC - PMC3224458
EDAT- 2011/09/13 06:00
MHDA- 2011/09/13 06:01
CRDT- 2011/09/13 06:00
PHST- 2011/02/14 00:00 [received]
PHST- 2011/04/13 00:00 [accepted]
PHST- 2011/09/13 06:00 [entrez]
PHST- 2011/09/13 06:00 [pubmed]
PHST- 2011/09/13 06:01 [medline]
AID - 2110-5820-1-8 [pii]
AID - 10.1186/2110-5820-1-8 [doi]
PST - epublish
SO  - Ann Intensive Care. 2011 Apr 13;1(1):8. doi: 10.1186/2110-5820-1-8.


PMID- 21906277
OWN - NLM
STAT- MEDLINE
DCOM- 20120202
LR  - 20211020
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 12
DP  - 2011 Sep 9
TI  - When is informed consent required in cluster randomized trials in health
      research?
PG  - 202
LID - 10.1186/1745-6215-12-202 [doi]
AB  - This article is part of a series of papers examining ethical issues in cluster
      randomized trials (CRTs) in health research. In the introductory paper in this
      series, we set out six areas of inquiry that must be addressed if the cluster
      trial is to be set on a firm ethical foundation. This paper addresses the second 
      of the questions posed, namely, from whom, when, and how must informed consent be
      obtained in CRTs in health research? The ethical principle of respect for persons
      implies that researchers are generally obligated to obtain the informed consent
      of research subjects. Aspects of CRT design, including cluster randomization,
      cluster level interventions, and cluster size, present challenges to obtaining
      informed consent. Here we address five questions related to consent and CRTs: How
      can a study proceed if informed consent is not possible? Is consent to
      randomization always required? What information must be disclosed to potential
      subjects if their cluster has already been randomized? Is passive consent a valid
      substitute for informed consent? Do health professionals have a moral obligation 
      to participate as subjects in CRTs designed to improve professional practice?We
      set out a framework based on the moral foundations of informed consent and
      international regulatory provisions to address each of these questions. First,
      when informed consent is not possible, a study may proceed if a research ethics
      committee is satisfied that conditions for a waiver of consent are satisfied.
      Second, informed consent to randomization may not be required if it is not
      possible to approach subjects at the time of randomization. Third, when potential
      subjects are approached after cluster randomization, they must be provided with a
      detailed description of the interventions in the trial arm to which their cluster
      has been randomized; detailed information on interventions in other trial arms
      need not be provided. Fourth, while passive consent may serve a variety of
      practical ends, it is not a substitute for valid informed consent. Fifth, while
      health professionals may have a moral obligation to participate as subjects in
      research, this does not diminish the necessity of informed consent to study
      participation.
FAU - McRae, Andrew D
AU  - McRae AD
AD  - Department of Epidemiology and Biostatistics, University of Western Ontario,
      London, ON N6A5C1, Canada. andrew.mcrae@albertahealthservices.ca
FAU - Weijer, Charles
AU  - Weijer C
FAU - Binik, Ariella
AU  - Binik A
FAU - Grimshaw, Jeremy M
AU  - Grimshaw JM
FAU - Boruch, Robert
AU  - Boruch R
FAU - Brehaut, Jamie C
AU  - Brehaut JC
FAU - Donner, Allan
AU  - Donner A
FAU - Eccles, Martin P
AU  - Eccles MP
FAU - Saginur, Raphael
AU  - Saginur R
FAU - White, Angela
AU  - White A
FAU - Taljaard, Monica
AU  - Taljaard M
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110909
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
SB  - IM
MH  - Humans
MH  - *Informed Consent
MH  - Randomized Controlled Trials as Topic/*ethics
MH  - Research Design
PMC - PMC3184061
EDAT- 2011/09/13 06:00
MHDA- 2012/02/03 06:00
CRDT- 2011/09/13 06:00
PHST- 2011/06/12 00:00 [received]
PHST- 2011/09/09 00:00 [accepted]
PHST- 2011/09/13 06:00 [entrez]
PHST- 2011/09/13 06:00 [pubmed]
PHST- 2012/02/03 06:00 [medline]
AID - 1745-6215-12-202 [pii]
AID - 10.1186/1745-6215-12-202 [doi]
PST - epublish
SO  - Trials. 2011 Sep 9;12:202. doi: 10.1186/1745-6215-12-202.


PMID- 21906248
OWN - NLM
STAT- MEDLINE
DCOM- 20120221
LR  - 20110912
IS  - 1751-7133 (Electronic)
IS  - 1527-5299 (Linking)
VI  - 17
IP  - 5
DP  - 2011 Sep-Oct
TI  - Ethics in the treatment of advanced heart failure: palliative care and
      end-of-life issues.
PG  - 235-40
LID - 10.1111/j.1751-7133.2011.00245.x [doi]
AB  - Advanced heart failure (HF) is a life-shortening condition, yet there are
      increasing treatments and implantable devices available to clinicians to manage
      patients with advanced HF. Planning for adverse events and the end of life,
      formulated as "preparedness planning," can be integrated into HF care early in
      illness. Discussions that acknowledge the uncertainty of HF course and length of 
      life and incorporate patient and family goals and values facilitates this
      planning. Clear processes for weighing potential benefits and burdens of
      interventions and therapies should accompany decision-making. Device implantation
      decision-making can acknowledge alternative avenues of care to the device and
      identify situations in which the device might be deactivated in the future.
      Symptom assessment and management potentially improve quality of life in patients
      with advanced HF. Management of symptoms should integrate HF therapies as well as
      other treatments. Collaboration between HF providers, palliative care clinicians,
      and, if appropriate, hospice clinicians will improve care for HF patients and
      their families.
CI  - (c) 2011 Wiley Periodicals, Inc.
FAU - Tanner, Craig E
AU  - Tanner CE
AD  - Division of General Internal Medicine and Geriatrics, Portland VAMC and Oregon
      Health and Science University, Portland, OR, USA.
FAU - Fromme, Erik K
AU  - Fromme EK
FAU - Goodlin, Sarah J
AU  - Goodlin SJ
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110801
PL  - United States
TA  - Congest Heart Fail
JT  - Congestive heart failure (Greenwich, Conn.)
JID - 9714174
SB  - IM
MH  - Heart Failure/*therapy
MH  - Humans
MH  - Palliative Care/*ethics
MH  - Terminal Care/*ethics
EDAT- 2011/09/13 06:00
MHDA- 2012/02/22 06:00
CRDT- 2011/09/13 06:00
PHST- 2011/09/13 06:00 [entrez]
PHST- 2011/09/13 06:00 [pubmed]
PHST- 2012/02/22 06:00 [medline]
AID - 10.1111/j.1751-7133.2011.00245.x [doi]
PST - ppublish
SO  - Congest Heart Fail. 2011 Sep-Oct;17(5):235-40. doi:
      10.1111/j.1751-7133.2011.00245.x. Epub 2011 Aug 1.


PMID- 21905845
OWN - NLM
STAT- MEDLINE
DCOM- 20120821
LR  - 20161018
IS  - 1557-900X (Electronic)
IS  - 0892-7790 (Linking)
VI  - 26
IP  - 5
DP  - 2012 May
TI  - Biomechanical proof of barbed sutures for the efficacy of laparoscopic
      pyeloplasty.
PG  - 540-4
LID - 10.1089/end.2011.0037 [doi]
AB  - BACKGROUND AND PURPOSE: The gold standard for management of adult ureteropelvic
      junction obstruction is laparoscopic dismembered pyeloplasty (LPP), described by 
      Anderson-Hynes, with reduced postoperative complications, early patient release, 
      and favorable results. LPP, however, necessitates a high level of surgical
      expertise, especially with regard to reanastomosis. Knotless self-anchoring
      barbed sutures have also been introduced into aesthetic surgery and wound
      closure. We compared a self-retaining suture (SRS) Quill((R)) (Angiotech, Canada)
      with a standard monofilament suture to further investigate their biomechanical
      and urodynamic aspects. MATERIALS AND METHODS: We analyzed breaking strength and 
      stiffness between SRS 4.0, 3.0, and polydioxanone suture (PDS((R))) 4.0 (Ethicon,
      Germany) using a biomechanical testing unit. Urodynamic evaluations were
      performed in the porcine upper urinary tract, closing a longitudinal incision
      either with SRS 4.0 (without knots) or with PDS 4.0 (five knots each end). Suture
      line shortening, suture time, tightness, and intrapelvic pressure were measured. 
      RESULTS: SRS 4.0 breaks at a mean of 11.57 N (standard deviation [SD]=1.25,
      stiffness 172.8 N/mm(2), SD=10.84), SRS 3.0 at 16.01 N (1.81), and PDS 4.0 at
      18.41 N (0.75, 128.9 N/mm(2), 7.45). SRS 4.0 results in a suture line shortening 
      from mean 3.08 to 2.26 mm (-26.6%) while PDS 4.0 shortens from 3.05 to 1.81 mm
      (-40.7%). The maximum intrapelvic pressure demonstrated no difference, and
      leakage was seen in 50% of the cases. Suture time was significantly decreased
      with SRS use (SRS 4.0 277 s and PDS 4.0 364 s). CONCLUSION: SRS offers immediate 
      tissue adaption with reduced suture line shortening and equal tightness compared 
      with nonbarbed material in vitro. Knotless suturing using SRS is time efficient
      and appears to be an excellent material for LPP.
FAU - Amend, Bastian
AU  - Amend B
AD  - Department of Urology, Eberhard Karl University of Tuebingen, Tuebingen, Germany.
FAU - Muller, Otto
AU  - Muller O
FAU - Bedke, Jens
AU  - Bedke J
FAU - Leichtle, Ulf
AU  - Leichtle U
FAU - Nagele, Udo
AU  - Nagele U
FAU - Kruck, Stephan
AU  - Kruck S
FAU - Stenzl, Arnulf
AU  - Stenzl A
FAU - Sievert, Karl-Dietrich
AU  - Sievert KD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110909
PL  - United States
TA  - J Endourol
JT  - Journal of endourology
JID - 8807503
SB  - IM
MH  - Adult
MH  - Animals
MH  - Biomechanical Phenomena
MH  - Humans
MH  - *Laparoscopy
MH  - Sus scrofa
MH  - *Sutures
MH  - Time Factors
MH  - Treatment Outcome
MH  - Urodynamics
MH  - Urologic Surgical Procedures/*methods
EDAT- 2011/09/13 06:00
MHDA- 2012/08/22 06:00
CRDT- 2011/09/13 06:00
PHST- 2011/09/13 06:00 [entrez]
PHST- 2011/09/13 06:00 [pubmed]
PHST- 2012/08/22 06:00 [medline]
AID - 10.1089/end.2011.0037 [doi]
PST - ppublish
SO  - J Endourol. 2012 May;26(5):540-4. doi: 10.1089/end.2011.0037. Epub 2011 Sep 9.


PMID- 21905568
OWN - NLM
STAT- MEDLINE
DCOM- 20111102
LR  - 20181201
IS  - 0025-8024 (Print)
IS  - 0025-8024 (Linking)
VI  - 51
IP  - 3
DP  - 2011 Jul
TI  - Psychiatric evidence in criminal courts: the need for better understanding.
PG  - 141-5
AB  - The rules of admissibility of expert evidence from mental health professionals
      are not clear. The task of a psychiatrist providing expert opinion to criminal
      courts is far from clear. Psychiatric experts are trained in a particular set of 
      ethical and philosophical frameworks. They have expertise in the diagnosis and
      management of behaviours arising from mental disorders. The concept of mental
      disorder itself is a dimensional one. Such a dimensional view of human behaviour 
      and mental disorders is hard to fit into the categorical view of human behaviour 
      that the law follows. The task of the psychiatric expert is to marry these two
      philosophically different branches. Such a task would be facilitated by clear
      rules of admissibility of expert psychiatric evidence, clear definition of the
      roles and limitations of psychiatric evidence in criminal cases, a better
      understanding and training of mental health professionals in legal principles and
      a better understanding by the legal professionals of the mental health concepts. 
      This article aims to analyse the legal basis of the admissibility of expert
      mental health evidence, the differences in the philosophies of the two
      disciplines and the challenges in addressing legal criteria while staying
      faithful to the ethos of psychiatry and psychology.
FAU - Muzaffar, Sajid
AU  - Muzaffar S
AD  - Norvic Clinic--Forensic Psychiatry, St Andrews Business Park, Thorpe St Andrews
      Norwich, Norfolk NR7 OHT, UK. sajidmuzaffar@yahoo.co.in
LA  - eng
PT  - Journal Article
PT  - Legal Case
PL  - England
TA  - Med Sci Law
JT  - Medicine, science, and the law
JID - 0400721
SB  - IM
MH  - Expert Testimony/*legislation & jurisprudence
MH  - Forensic Psychiatry/*legislation & jurisprudence
MH  - Humans
MH  - United Kingdom
EDAT- 2011/09/13 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/09/13 06:00
PHST- 2011/09/13 06:00 [entrez]
PHST- 2011/09/13 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
AID - 10.1258/msl.2011.010144 [doi]
PST - ppublish
SO  - Med Sci Law. 2011 Jul;51(3):141-5. doi: 10.1258/msl.2011.010144.


PMID- 21905567
OWN - NLM
STAT- MEDLINE
DCOM- 20111102
LR  - 20170214
IS  - 0025-8024 (Print)
IS  - 0025-8024 (Linking)
VI  - 51
IP  - 3
DP  - 2011 Jul
TI  - Ethical and legal issues in organ transplantation: Indian scenario.
PG  - 134-40
AB  - In 1994, the Government of India enacted the Transplantation of Human Organs Act 
      (THOA) to prevent commercial dealings in human organs. However, a greater number 
      of scandals involving medical practitioners and others in the kidney trade has
      surfaced periodically in every state in India. The present regulatory system has 
      failed mainly due to the misuse of Section 9(3) of the THOA, which approves the
      consent given by a live unrelated donor for the removal of organs for the reason 
      of affection or attachment towards the recipient or for any other special reason.
      Currently in India, approximately 3500-4000 kidney transplants and 150-200 liver 
      transplants are performed annually. However, the availability of organs from
      brain-dead persons is very low. As a result, live related or unrelated donors
      form the main source of organ transplantation. Therefore, physicians and
      policy-makers should re-examine the value of introducing regulated
      incentive-based organ donation to increase the supply of organs for
      transplantation and to end unlawful financial transaction.
FAU - Mathiharan, Karunakaran
AU  - Mathiharan K
AD  - Forensic Unit, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur,
      Malaysia. legalmedicine@gmail.com
LA  - eng
PT  - Journal Article
PL  - England
TA  - Med Sci Law
JT  - Medicine, science, and the law
JID - 0400721
SB  - IM
MH  - Commerce/*legislation & jurisprudence
MH  - Humans
MH  - India
MH  - Organ Transplantation/*ethics/*legislation & jurisprudence/statistics & numerical
      data
MH  - Religion and Medicine
MH  - Tissue Donors/supply & distribution
MH  - Tissue and Organ Procurement/ethics/*legislation & jurisprudence
EDAT- 2011/09/13 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/09/13 06:00
PHST- 2011/09/13 06:00 [entrez]
PHST- 2011/09/13 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
AID - 10.1258/msl.2011.010134 [doi]
PST - ppublish
SO  - Med Sci Law. 2011 Jul;51(3):134-40. doi: 10.1258/msl.2011.010134.


PMID- 21905552
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20110912
IS  - 1071-2984 (Print)
IS  - 1071-2984 (Linking)
VI  - 31
IP  - 2
DP  - 2011 Spring
TI  - Nurse Jackie and nurse ethics: How TV and the media influence our public image.
PG  - 8-10
FAU - Nemeth, Lynne
AU  - Nemeth L
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Beginnings
JT  - Beginnings (American Holistic Nurses' Association)
JID - 9303087
MH  - *Ethics, Nursing
MH  - *Holistic Health
MH  - Holistic Nursing/*ethics
MH  - Humans
MH  - *Nurse's Role
MH  - Public Opinion
MH  - *Social Perception
MH  - *Television
MH  - United States
EDAT- 2011/09/13 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/09/13 06:00
PHST- 2011/09/13 06:00 [entrez]
PHST- 2011/09/13 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
PST - ppublish
SO  - Beginnings. 2011 Spring;31(2):8-10.


PMID- 21904557
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1687-9678 (Electronic)
VI  - 2011
DP  - 2011
TI  - From banking to international governance: fostering innovation in stem cell
      research.
PG  - 498132
LID - 10.4061/2011/498132 [doi]
AB  - Stem cell banks are increasingly recognized as an essential resource of
      biological materials for both basic and translational stem cell research. By
      providing transnational access to quality controlled and ethically sourced stem
      cell lines, stem cell banks seek to foster international collaboration and
      innovation. However, given that national stem cell banks operate under different 
      policy, regulatory and commercial frameworks, the transnational sharing of stem
      cell materials and data can be complicating. This paper will provide an overview 
      of the most pressing challenges regarding the governance of stem cell banks, and 
      the difficulties in designing regulatory and commercial frameworks that foster
      stem cell research. Moreover, the paper will shed light on the numerous
      international initiatives that have arisen to help harmonize and standardize stem
      cell banking and research processes to overcome such challenges.
FAU - Isasi, Rosario
AU  - Isasi R
AD  - Centre of Genomics and Policy, McGill University, Montreal, QC, Canada H3A 1A1.
FAU - Knoppers, Bartha M
AU  - Knoppers BM
LA  - eng
PT  - Journal Article
DEP - 20110905
PL  - United States
TA  - Stem Cells Int
JT  - Stem cells international
JID - 101535822
PMC - PMC3167189
EDAT- 2011/09/10 06:00
MHDA- 2011/09/10 06:01
CRDT- 2011/09/10 06:00
PHST- 2011/03/24 00:00 [received]
PHST- 2011/06/07 00:00 [accepted]
PHST- 2011/09/10 06:00 [entrez]
PHST- 2011/09/10 06:00 [pubmed]
PHST- 2011/09/10 06:01 [medline]
AID - 10.4061/2011/498132 [doi]
PST - ppublish
SO  - Stem Cells Int. 2011;2011:498132. doi: 10.4061/2011/498132. Epub 2011 Sep 5.


PMID- 21904102
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20220317
IS  - 1941-9260 (Electronic)
IS  - 0032-5481 (Linking)
VI  - 123
IP  - 5
DP  - 2011 Sep
TI  - Key concepts of clinical trials: a narrative review.
PG  - 194-204
LID - 10.3810/pgm.2011.09.2475 [doi]
AB  - The recent focus of federal funding on comparative effectiveness research
      underscores the importance of clinical trials in the practice of evidence-based
      medicine and health care reform. The impact of clinical trials not only extends
      to the individual patient by establishing a broader selection of effective
      therapies, but also to society as a whole by enhancing the value of health care
      provided. However, clinical trials also have the potential to pose unknown risks 
      to their participants, and biased knowledge extracted from flawed clinical trials
      may lead to the inadvertent harm of patients. Although conducting a well-designed
      clinical trial may appear straightforward, it is founded on rigorous methodology 
      and oversight governed by key ethical principles. In this review, we provide an
      overview of the ethical foundations of trial design, trial oversight, and the
      process of obtaining approval of a therapeutic, from its pre-clinical phase to
      post-marketing surveillance. This narrative review is based on a course in
      clinical trials developed by one of the authors (DJM), and is supplemented by a
      PubMed search predating January 2011 using the keywords "randomized controlled
      trial," "patient/clinical research," "ethics," "phase IV," "data and safety
      monitoring board," and "surrogate endpoint." With an understanding of the key
      principles in designing and implementing clinical trials, health care providers
      can partner with the pharmaceutical industry and regulatory bodies to effectively
      compare medical therapies and thereby meet one of the essential goals of health
      care reform.
FAU - Umscheid, Craig A
AU  - Umscheid CA
AD  - Center for Evidence-Based Practice, University of Pennsylvania, Philadelphia, PA,
      USA.
FAU - Margolis, David J
AU  - Margolis DJ
FAU - Grossman, Craig E
AU  - Grossman CE
LA  - eng
GR  - T32 CA009677/CA/NCI NIH HHS/United States
GR  - T32 CA009677-07/CA/NCI NIH HHS/United States
GR  - T32-CA-009677/CA/NCI NIH HHS/United States
GR  - T32-HP-010026/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - England
TA  - Postgrad Med
JT  - Postgraduate medicine
JID - 0401147
SB  - IM
MH  - Clinical Trials, Phase I as Topic
MH  - Clinical Trials, Phase II as Topic
MH  - Clinical Trials, Phase III as Topic
MH  - Clinical Trials, Phase IV as Topic
MH  - Drug Evaluation/methods
MH  - Humans
MH  - *Randomized Controlled Trials as Topic/ethics/methods/standards
MH  - United States
PMC - PMC3272827
MID - NIHMS350738
EDAT- 2011/09/10 06:00
MHDA- 2011/11/09 06:00
CRDT- 2011/09/10 06:00
PHST- 2011/09/10 06:00 [entrez]
PHST- 2011/09/10 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - 10.3810/pgm.2011.09.2475 [doi]
PST - ppublish
SO  - Postgrad Med. 2011 Sep;123(5):194-204. doi: 10.3810/pgm.2011.09.2475.


PMID- 21903906
OWN - NLM
STAT- MEDLINE
DCOM- 20120208
LR  - 20111006
IS  - 1744-5019 (Electronic)
IS  - 0360-5310 (Linking)
VI  - 36
IP  - 4
DP  - 2011 Aug
TI  - Enhancement technologies and the modern self.
PG  - 364-74
LID - 10.1093/jmp/jhr031 [doi]
AB  - Many people feel uneasy about enhancement technologies, yet have a hard time
      explaining why. This unease is often less with the technologies themselves than
      about the desires and aspirations that they express. I suggest here that we can
      diagnose the source of that unease by looking at three themes that emerge in
      Taylor's writings about the making of the modern self: the importance of social
      recognition, the ethics of authenticity, and the rise of instrumental reason.
FAU - Elliott, Carl
AU  - Elliott C
AD  - Center for Bioethics, University of Minnesota, 410 Church Street SE, Minneapolis,
      MN 55455, USA. ellio023@umn.edu
LA  - eng
PT  - Journal Article
DEP - 20110908
PL  - United States
TA  - J Med Philos
JT  - The Journal of medicine and philosophy
JID - 7610512
SB  - IM
MH  - Biomedical Enhancement/*ethics
MH  - *Ego
MH  - Humans
MH  - Morals
MH  - *Philosophy, Medical
MH  - Social Identification
EDAT- 2011/09/10 06:00
MHDA- 2012/02/09 06:00
CRDT- 2011/09/10 06:00
PHST- 2011/09/10 06:00 [entrez]
PHST- 2011/09/10 06:00 [pubmed]
PHST- 2012/02/09 06:00 [medline]
AID - jhr031 [pii]
AID - 10.1093/jmp/jhr031 [doi]
PST - ppublish
SO  - J Med Philos. 2011 Aug;36(4):364-74. doi: 10.1093/jmp/jhr031. Epub 2011 Sep 8.


PMID- 21903726
OWN - NLM
STAT- MEDLINE
DCOM- 20120427
LR  - 20120220
IS  - 1460-2156 (Electronic)
IS  - 0006-8950 (Linking)
VI  - 135
IP  - Pt 2
DP  - 2012 Feb
TI  - Significant clinical, neuropathological and behavioural recovery from acute
      spinal cord trauma by transplantation of a well-defined somatic stem cell from
      human umbilical cord blood.
PG  - 431-46
LID - 10.1093/brain/awr222 [doi]
AB  - Stem cell therapy is a potential treatment for spinal cord injury and different
      stem cell types have been grafted into animal models and humans suffering from
      spinal trauma. Due to inconsistent results, it is still an important and
      clinically relevant question which stem cell type will prove to be
      therapeutically effective. Thus far, stem cells of human sources grafted into
      spinal cord mostly included barely defined heterogeneous mesenchymal stem cell
      populations derived from bone marrow or umbilical cord blood. Here, we have
      transplanted a well-defined unrestricted somatic stem cell isolated from human
      umbilical cord blood into an acute traumatic spinal cord injury of adult immune
      suppressed rat. Grafting of unrestricted somatic stem cells into the vicinity of 
      a dorsal hemisection injury at thoracic level eight resulted in hepatocyte growth
      factor-directed migration and accumulation within the lesion area, reduction in
      lesion size and augmented tissue sparing, enhanced axon regrowth and significant 
      functional locomotor improvement as revealed by three behavioural tasks (open
      field Basso-Beattie-Bresnahan locomotor score, horizontal ladder walking test and
      CatWalk gait analysis). To accomplish the beneficial effects, neither neural
      differentiation nor long-lasting persistence of the grafted human stem cells
      appears to be required. The secretion of neurite outgrowth-promoting factors in
      vitro further suggests a paracrine function of unrestricted somatic stem cells in
      spinal cord injury. Given the highly supportive functional characteristics in
      spinal cord injury, production in virtually unlimited quantities at GMP grade and
      lack of ethical concerns, unrestricted somatic stem cells appear to be a highly
      suitable human stem cell source for clinical application in central nervous
      system injuries.
FAU - Schira, Jessica
AU  - Schira J
AD  - Molecular Neurobiology Laboratory, Department of Neurology,
      Heinrich-Heine-University Medical Centre Dusseldorf, Moorenstr. 5, 40223
      Dusseldorf, Germany.
FAU - Gasis, Marcia
AU  - Gasis M
FAU - Estrada, Veronica
AU  - Estrada V
FAU - Hendricks, Marion
AU  - Hendricks M
FAU - Schmitz, Christine
AU  - Schmitz C
FAU - Trapp, Thorsten
AU  - Trapp T
FAU - Kruse, Fabian
AU  - Kruse F
FAU - Kogler, Gesine
AU  - Kogler G
FAU - Wernet, Peter
AU  - Wernet P
FAU - Hartung, Hans-Peter
AU  - Hartung HP
FAU - Muller, Hans Werner
AU  - Muller HW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110908
PL  - England
TA  - Brain
JT  - Brain : a journal of neurology
JID - 0372537
SB  - IM
MH  - Animals
MH  - Axons/physiology
MH  - Cells, Cultured
MH  - *Cord Blood Stem Cell Transplantation
MH  - Female
MH  - Humans
MH  - Motor Activity/physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Recovery of Function/*physiology
MH  - Spinal Cord Injuries/physiopathology/*therapy
EDAT- 2011/09/10 06:00
MHDA- 2012/04/28 06:00
CRDT- 2011/09/10 06:00
PHST- 2011/09/10 06:00 [entrez]
PHST- 2011/09/10 06:00 [pubmed]
PHST- 2012/04/28 06:00 [medline]
AID - awr222 [pii]
AID - 10.1093/brain/awr222 [doi]
PST - ppublish
SO  - Brain. 2012 Feb;135(Pt 2):431-46. doi: 10.1093/brain/awr222. Epub 2011 Sep 8.


PMID- 21903496
OWN - NLM
STAT- MEDLINE
DCOM- 20121026
LR  - 20151119
IS  - 1878-1799 (Electronic)
IS  - 1871-5192 (Linking)
VI  - 25
IP  - 3
DP  - 2012 Sep
TI  - Women's perceptions of their healthcare experience when they choose not to
      breastfeed.
PG  - 135-41
LID - 10.1016/j.wombi.2011.08.005 [doi]
AB  - RESEARCH QUESTION: How do women who choose not to breastfeed perceive their
      healthcare experience? METHOD: This qualitative research study used a
      phenomenographic approach to explore the healthcare experience of women who do
      not breastfeed. Seven women were interviewed about their healthcare experience
      relating to their choice of feeding, approximately 4 weeks after giving birth.
      Six conceptions were identified and an outcome space was developed to demonstrate
      the relationships and meaning of the conceptions in a visual format. FINDINGS:
      There were five unmet needs identified by the participants during this study.
      These needs included equity, self sufficiency, support, education and the need
      not to feel pressured. CONCLUSION: Women in this study who chose not to
      breastfeed identified important areas where they felt that their needs were not
      met. In keeping with the Code of Ethics for Nurses and Midwives, the identified
      needs of women who do not breastfeed must be addressed in a caring, compassionate
      and just manner. The care and education of women who formula feed should be of
      the highest standard possible, even if the choice not to breastfeed is not the
      preferred choice of healthcare professionals.
CI  - Copyright (c) 2011 Australian College of Midwives. Published by Elsevier Ltd. All
      rights reserved.
FAU - Wirihana, Lisa A
AU  - Wirihana LA
AD  - School of Nursing and, Midwifery at Queensland University of Technology, Victoria
      Park Road, Kelvin Grove, QLD 4059, Australia. l.wirihana@qut.edu.au
FAU - Barnard, Alan
AU  - Barnard A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110907
PL  - Netherlands
TA  - Women Birth
JT  - Women and birth : journal of the Australian College of Midwives
JID - 101266131
MH  - Adult
MH  - Attitude of Health Personnel
MH  - Australia
MH  - Bottle Feeding/*psychology
MH  - *Breast Feeding
MH  - Choice Behavior
MH  - Decision Making
MH  - Delivery of Health Care
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Health Services Needs and Demand
MH  - Humans
MH  - Infant, Newborn
MH  - Interviews as Topic
MH  - Mothers/*psychology
MH  - Perception
MH  - Postpartum Period
MH  - Pregnancy
MH  - Qualitative Research
MH  - Social Support
MH  - Surveys and Questionnaires
EDAT- 2011/09/10 06:00
MHDA- 2012/10/27 06:00
CRDT- 2011/09/10 06:00
PHST- 2011/03/31 00:00 [received]
PHST- 2011/08/10 00:00 [revised]
PHST- 2011/08/10 00:00 [accepted]
PHST- 2011/09/10 06:00 [entrez]
PHST- 2011/09/10 06:00 [pubmed]
PHST- 2012/10/27 06:00 [medline]
AID - S1871-5192(11)00208-3 [pii]
AID - 10.1016/j.wombi.2011.08.005 [doi]
PST - ppublish
SO  - Women Birth. 2012 Sep;25(3):135-41. doi: 10.1016/j.wombi.2011.08.005. Epub 2011
      Sep 7.


PMID- 21903491
OWN - NLM
STAT- MEDLINE
DCOM- 20120403
LR  - 20111128
IS  - 1695-9531 (Electronic)
IS  - 1695-4033 (Linking)
VI  - 75
IP  - 6
DP  - 2011 Dec
TI  - [The Spanish Paediatric Association ethical framework: a commitment to the ethics
      of organizations].
PG  - 355-7
LID - 10.1016/j.anpedi.2011.07.014 [doi]
FAU - Jacob, M Sanchez
AU  - Jacob MS
LA  - spa
PT  - Editorial
TT  - El marco etico de la Asociacion Espanola de Pediatria: un compromiso con la etica
      de las organizaciones.
DEP - 20110907
PL  - Spain
TA  - An Pediatr (Barc)
JT  - Anales de pediatria (Barcelona, Spain : 2003)
JID - 101162596
SB  - IM
MH  - Bioethical Issues
MH  - *Ethics, Institutional
MH  - Pediatrics/*ethics
MH  - Societies, Medical/*ethics
MH  - Spain
EDAT- 2011/09/10 06:00
MHDA- 2012/04/04 06:00
CRDT- 2011/09/10 06:00
PHST- 2011/07/15 00:00 [received]
PHST- 2011/07/15 00:00 [accepted]
PHST- 2011/09/10 06:00 [entrez]
PHST- 2011/09/10 06:00 [pubmed]
PHST- 2012/04/04 06:00 [medline]
AID - S1695-4033(11)00383-3 [pii]
AID - 10.1016/j.anpedi.2011.07.014 [doi]
PST - ppublish
SO  - An Pediatr (Barc). 2011 Dec;75(6):355-7. doi: 10.1016/j.anpedi.2011.07.014. Epub 
      2011 Sep 7.


PMID- 21902466
OWN - NLM
STAT- MEDLINE
DCOM- 20120516
LR  - 20161125
IS  - 1937-335X (Electronic)
IS  - 1937-3341 (Linking)
VI  - 18
IP  - 3-4
DP  - 2012 Feb
TI  - Insulin-like growth factor 2 promotes osteogenic cell differentiation in the
      parthenogenetic murine embryonic stem cells.
PG  - 331-41
LID - 10.1089/ten.TEA.2011.0074 [doi]
AB  - Embryonic stem cells (ESCs) are pluripotent and can differentiate into all
      somatic cell types. ESCs are an alternative solution to hard tissue regeneration 
      and skeletal tissue repair to treat bone diseases and defects using regenerative 
      strategies. Parthenogenetic ESCs (PESCs) may be a useful alternative stem cell
      source for tissue repair and regeneration. The defects in full-term development
      of this cell type enable researchers to avoid the ethical concerns related to ESC
      research. Moreover, in female patients, if the PESCs are derived from oocytes,
      then they will have that patient's genetic information. Here, we present data
      demonstrating that osteogenic differentiation of PESCs can be promoted by
      insulin-like growth factor 2 (IGF2). PESCs were plated onto Petri dishes with ESC
      culture medium supplemented with or without IGF2, followed by culturing of the
      cells for 1 week. PESCs formed floating aggregates called embryoid bodies (EBs). 
      An osteogenic lineage was induced from the EBs by incubating them in medium
      containing serum, ascorbic acid, beta-glycerophosphate, and retionic acid, with
      or without IGF2, for 20 days. Gene expression of specific osteoblastic markers
      such as osteocalcin, osteopontin, osteonectin, bone sialoprotein, collagen
      type-I, alkaline phosphatase, and Runx2 (Cbfa-I) was analyzed by real-time
      polymerase chain reaction. The expression level of osteocalcin, osteopontin,
      osteonectin, and alkaline phosphatase was twofold higher in IGF2-treated PESC
      derivatives than IGF2-naive PESC derivatives. In vivo experiments were also
      performed using a critical-sized calvarial defect mouse model. Ten weeks after
      cell transplantation, more bone tissue regeneration was observed in the
      IGF2-treated PESC transplantation group than in IGF2-naive PESC transplantation
      group. Both our in vitro and in vivo data indicate that IGF2 induces osteogenic
      differentiation of PESCs. Addition of IGF2 may reactivate imprinting genes in
      PESCs that are only expressed in the paternal genome and are normally silent in
      PESCs. Our findings provide insights into the mechanisms of skeletal tissue
      repair and the imprinting mechanisms active in stem cells.
FAU - Kang, Hoin
AU  - Kang H
AD  - Cellular Reprogramming and Embryo Biotechnology Laboratory, Dental Research
      Institute and CLS21, Seoul National University School of Dentistry, Seoul,
      Republic of Korea.
FAU - Sung, Jihye
AU  - Sung J
FAU - Jung, Hong-Moon
AU  - Jung HM
FAU - Woo, Kyung Mi
AU  - Woo KM
FAU - Hong, Seong-Doo
AU  - Hong SD
FAU - Roh, Sangho
AU  - Roh S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111018
PL  - United States
TA  - Tissue Eng Part A
JT  - Tissue engineering. Part A
JID - 101466659
RN  - 67763-97-7 (Insulin-Like Growth Factor II)
SB  - IM
MH  - Animals
MH  - Bone Regeneration/drug effects/genetics
MH  - Bone and Bones/cytology/drug effects/metabolism
MH  - Cell Differentiation/*drug effects/genetics
MH  - Embryoid Bodies/cytology/drug effects/metabolism
MH  - Embryonic Stem Cells/*cytology/drug effects/metabolism
MH  - Female
MH  - Gene Expression Regulation/drug effects
MH  - Humans
MH  - Insulin-Like Growth Factor II/*pharmacology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Microscopy, Electron, Scanning
MH  - Osteogenesis/*drug effects/genetics
MH  - Parthenogenesis/*drug effects/genetics
MH  - Prosthesis Implantation
MH  - Skull/diagnostic imaging/drug effects/pathology
MH  - Tissue Scaffolds/chemistry
MH  - X-Ray Microtomography
EDAT- 2011/09/10 06:00
MHDA- 2012/05/17 06:00
CRDT- 2011/09/10 06:00
PHST- 2011/09/10 06:00 [entrez]
PHST- 2011/09/10 06:00 [pubmed]
PHST- 2012/05/17 06:00 [medline]
AID - 10.1089/ten.TEA.2011.0074 [doi]
PST - ppublish
SO  - Tissue Eng Part A. 2012 Feb;18(3-4):331-41. doi: 10.1089/ten.TEA.2011.0074. Epub 
      2011 Oct 18.


PMID- 21894616
OWN - NLM
STAT- MEDLINE
DCOM- 20131112
LR  - 20130516
IS  - 1756-5391 (Electronic)
IS  - 1756-5391 (Linking)
VI  - 4
IP  - 3
DP  - 2011
TI  - The Sri Lanka Clinical Trials Registry--moving forward.
PG  - 179-81
LID - 10.1111/j.1756-5391.2011.01141.x [doi]
AB  - The Sri Lanka Clinical Trials Registry (SLCTR) is a Primary Registry in the
      Registry Network of the World Health Organization's International Clinical Trials
      Registry Platform (WHO-ICTRP), and regularly feeds data to its Clinical Trials
      Search Portal. Over the last few years, the SLCTR has been able to achieve its
      original objective of providing a national trial register for Sri Lankan
      researchers, but its role has always been more than that of a mere storehouse of 
      trial data. The research landscape is rapidly changing in Sri Lanka, and the
      SLCTR has been a key stimulus to a resurgent interest in clinical research among 
      the Sri Lankan research community. The SLCTR is working together with its partner
      stakeholders to facilitate research in the country, and to ensure that clinical
      trials conducted in Sri Lanka meet the highest ethical and scientific standards.
CI  - (c) 2011 Blackwell Publishing Asia Pty Ltd and Chinese Cochrane Center, West
      China Hospital of Sichuan University.
FAU - Ranawaka, Udaya K
AU  - Ranawaka UK
AD  - Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
      udayaran@yahoo.com
FAU - Goonaratna, Colvin
AU  - Goonaratna C
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Evid Based Med
JT  - Journal of evidence-based medicine
JID - 101497477
SB  - IM
MH  - Clinical Trials as Topic/standards/*trends
MH  - Humans
MH  - *Registries/standards
MH  - Sri Lanka
EDAT- 2011/09/10 06:00
MHDA- 2013/11/13 06:00
CRDT- 2011/09/07 06:00
PHST- 2011/09/07 06:00 [entrez]
PHST- 2011/09/10 06:00 [pubmed]
PHST- 2013/11/13 06:00 [medline]
AID - 10.1111/j.1756-5391.2011.01141.x [doi]
PST - ppublish
SO  - J Evid Based Med. 2011;4(3):179-81. doi: 10.1111/j.1756-5391.2011.01141.x.


PMID- 21894615
OWN - NLM
STAT- MEDLINE
DCOM- 20131112
LR  - 20130516
IS  - 1756-5391 (Electronic)
IS  - 1756-5391 (Linking)
VI  - 4
IP  - 3
DP  - 2011
TI  - The Cuban Public Registry of Clinical Trials: primary registry of World Health
      Organization.
PG  - 161-4
LID - 10.1111/j.1756-5391.2011.01140.x [doi]
AB  - Despite the importance of randomized trials for well-informed decisions in health
      care, a large proportion of the results of these trials are not published,
      especially when they are negative. Publication bias has a negative impact in the 
      treatment of patients, due to the distorted impression it leads to for new
      therapies. Clinical Trial Registries help to overcome this by providing
      transparency in the process of conducting research. The World Health Organization
      takes the position that the registration of interventional trials is a
      scientific, ethical and moral responsibility. Taking account of this global
      movement, the National Coordinating Centre of Clinical Trials and the Cuban
      Health Network, designed and implemented the Cuban Public Registry of Clinical
      Trials. The Registry was established in June 2007 and is intended for public
      service in Cuban territory, although it is open to registrants and patients
      outside Cuba. The Registry staff developed a strategy to become a Primary
      Registry of the World Health Organization, and this was achieved in February
      2011.
CI  - (c) 2011 Blackwell Publishing Asia Pty Ltd and Chinese Cochrane Center, West
      China Hospital of Sichuan University.
FAU - Jimenez, Gladys
AU  - Jimenez G
AD  - National Coordinating Centre of Clinical Trials, La Habana, Cuba.
      gladys@cencec.sld.cu
FAU - Pascual, Maria Amparo
AU  - Pascual MA
FAU - Fors, Martha
AU  - Fors M
FAU - Cobas, Jose
AU  - Cobas J
FAU - Torres, Ania
AU  - Torres A
FAU - Cachimaille, Yamile
AU  - Cachimaille Y
FAU - Rodriguez, Julian
AU  - Rodriguez J
FAU - Lopez, Isabel
AU  - Lopez I
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Evid Based Med
JT  - Journal of evidence-based medicine
JID - 101497477
SB  - IM
MH  - Biomedical Research
MH  - *Clinical Trials as Topic
MH  - Cuba
MH  - Humans
MH  - *Registries
MH  - *World Health Organization
EDAT- 2011/09/10 06:00
MHDA- 2013/11/13 06:00
CRDT- 2011/09/07 06:00
PHST- 2011/09/07 06:00 [entrez]
PHST- 2011/09/10 06:00 [pubmed]
PHST- 2013/11/13 06:00 [medline]
AID - 10.1111/j.1756-5391.2011.01140.x [doi]
PST - ppublish
SO  - J Evid Based Med. 2011;4(3):161-4. doi: 10.1111/j.1756-5391.2011.01140.x.


PMID- 21894612
OWN - NLM
STAT- MEDLINE
DCOM- 20131112
LR  - 20211008
IS  - 1756-5391 (Electronic)
IS  - 1756-5391 (Linking)
VI  - 4
IP  - 3
DP  - 2011
TI  - Chinese Clinical Trial Registry: mission, responsibility and operation.
PG  - 165-7
LID - 10.1111/j.1756-5391.2011.01137.x [doi]
AB  - As a national public clinical trial registry and a recognized Primary Registry of
      the WHO ICTRP, the Chinese Clinical Trial Registry (ChiCTR) has responsibility to
      disseminate knowledge about clinical trial transparency, which is an important
      ethical issue for healthcare studies involving humans, and to promote the quality
      of healthcare studies in China. This article describes the mission, policy and
      operation of the ChiCTR. We discuss the need to improve the quality of clinical
      trials and our ideas for new developments. The registration of clinical trials is
      an ethical responsibility and obligation for researchers. A clinical study is a
      public event itself, which needs the participation of the public, and its results
      should also be seen as a service to the public. Therefore, the public have the
      right to know how a study is progressing.
CI  - (c) 2011 Blackwell Publishing Asia Pty Ltd and Chinese Cochrane Center, West
      China Hospital of Sichuan University.
FAU - Wu, Taixiang
AU  - Wu T
AD  - Chinese Clinical Registry, Chinese Cochrane Centre, Chinese Evidence-Based
      Medicine Centre, INCLEN CERTC, West China Hospital, Sichuan University, Chengdu
      610041, China.
FAU - Li, Youping
AU  - Li Y
FAU - Liu, Guanjian
AU  - Liu G
FAU - Li, Jing
AU  - Li J
FAU - Wang, Li
AU  - Wang L
FAU - Du, Liang
AU  - Du L
CN  - Chinese Clinical Registry
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Evid Based Med
JT  - Journal of evidence-based medicine
JID - 101497477
SB  - IM
MH  - China
MH  - *Clinical Trials as Topic
MH  - Humans
MH  - *Registries/standards
EDAT- 2011/09/10 06:00
MHDA- 2013/11/13 06:00
CRDT- 2011/09/07 06:00
PHST- 2011/09/07 06:00 [entrez]
PHST- 2011/09/10 06:00 [pubmed]
PHST- 2013/11/13 06:00 [medline]
AID - 10.1111/j.1756-5391.2011.01137.x [doi]
PST - ppublish
SO  - J Evid Based Med. 2011;4(3):165-7. doi: 10.1111/j.1756-5391.2011.01137.x.


PMID- 21901047
OWN - NLM
STAT- MEDLINE
DCOM- 20111102
LR  - 20110908
IS  - 0807-7096 (Electronic)
IS  - 0029-2001 (Linking)
VI  - 131
IP  - 17
DP  - 2011 Sep 6
TI  - [Ethical aspects of physician-patient relations in the new media].
PG  - 1677-9
LID - 10.4045/tidsskr.11.0789 [doi]
FAU - Becker, Frank
AU  - Becker F
AD  - Klinikk for hjerneskader, Sunnaas sykehus, Norway. frank.becker@sunnaas.no
LA  - nor
PT  - Journal Article
TT  - Etiske aspekter ved lege-pasient-relasjoner i nye medier.
PL  - Norway
TA  - Tidsskr Nor Laegeforen
JT  - Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny
      raekke
JID - 0413423
SB  - IM
MH  - Communication
MH  - Confidentiality/*ethics
MH  - Ethics Committees
MH  - Guidelines as Topic
MH  - Humans
MH  - *Internet
MH  - Norway
MH  - Physician-Patient Relations/*ethics
EDAT- 2011/09/09 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/09/09 06:00
PHST- 2011/09/09 06:00 [entrez]
PHST- 2011/09/09 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
AID - 2132429 [pii]
AID - 10.4045/tidsskr.11.0789 [doi]
PST - ppublish
SO  - Tidsskr Nor Laegeforen. 2011 Sep 6;131(17):1677-9. doi: 10.4045/tidsskr.11.0789.


PMID- 21900619
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20220318
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 261
IP  - 2
DP  - 2011 Nov
TI  - Color and power Doppler US for diagnosing carpal tunnel syndrome and determining 
      its severity: a quantitative image processing method.
PG  - 499-506
LID - 10.1148/radiol.11110150 [doi]
AB  - PURPOSE: To determine whether intraneural vascularity seen at color Doppler
      ultrasonography (US) can be used to diagnose carpal tunnel syndrome (CTS) and to 
      evaluate an image processing method for quantifying the severity of CTS on the
      basis of this vascularity. MATERIALS AND METHODS: This study was approved by the 
      university ethics review committee. One hundred one patients with clinical
      evidence of CTS and 55 healthy control subjects were enrolled. Electrodiagnostic 
      testing (EDT) was performed in all participants, and the presence of intraneural 
      vascularity was evaluated with color Doppler US. An image processing program was 
      designed by using software to determine the sum of pixels in the intraneural
      vascular area on power Doppler US scans of the median nerve. The relationship
      between the number of pixels and the severity of the abnormality at EDT was
      determined. RESULTS: The sensitivity (83%) and specificity (89%) of intraneural
      vascularity in the diagnosis of CTS were similar to those of EDT (81% and 84%,
      respectively). Intraneural vascularity was seen in 91.4% of patients with mild
      CTS and 100% of patients with moderate or severe CTS. In participants with
      positive intraneural vascularity, the sum of pixels in the intraneural vascular
      area was significantly higher in patients than in control subjects and paralleled
      the severity of the abnormality at EDT (P < .01). CONCLUSION: Color Doppler US
      can be used to accurately diagnose CTS. By processing the recorded power Doppler 
      images and determining the number of pixels in the intraneural vascular area, the
      severity of CTS can be assessed. 2011 SUPPLEMENTAL MATERIAL:
      http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.11110150/-/DC1.
CI  - RSNA, 2011
FAU - Ghasemi-Esfe, Ahmad Reza
AU  - Ghasemi-Esfe AR
AD  - Advanced Diagnostic and Interventional Radiology Research Center, Imam Hospital, 
      Tehran University of Medical Sciences, Keshavarz Blvd, Tehran 13145-784, Iran.
FAU - Khalilzadeh, Omid
AU  - Khalilzadeh O
FAU - Vaziri-Bozorg, Seyed Mehran
AU  - Vaziri-Bozorg SM
FAU - Jajroudi, Mahdie
AU  - Jajroudi M
FAU - Shakiba, Madjid
AU  - Shakiba M
FAU - Mazloumi, Mehdi
AU  - Mazloumi M
FAU - Rahmani, Maryam
AU  - Rahmani M
LA  - eng
PT  - Journal Article
DEP - 20110907
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
CIN - Radiology. 2012 Mar;262(3):1043-4; author reply 1044. PMID: 22357906
MH  - Adult
MH  - Aged
MH  - Carpal Tunnel Syndrome/*diagnostic imaging
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Electrodiagnosis
MH  - Female
MH  - Humans
MH  - *Image Interpretation, Computer-Assisted
MH  - Male
MH  - Median Nerve/*blood supply/*diagnostic imaging
MH  - Middle Aged
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
MH  - Ultrasonography, Doppler/*methods
MH  - Ultrasonography, Doppler, Color
EDAT- 2011/09/09 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/09/09 06:00
PHST- 2011/09/09 06:00 [entrez]
PHST- 2011/09/09 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - radiol.11110150 [pii]
AID - 10.1148/radiol.11110150 [doi]
PST - ppublish
SO  - Radiology. 2011 Nov;261(2):499-506. doi: 10.1148/radiol.11110150. Epub 2011 Sep
      7.


PMID- 21900540
OWN - NLM
STAT- MEDLINE
DCOM- 20120208
LR  - 20220311
IS  - 1744-5019 (Electronic)
IS  - 0360-5310 (Linking)
VI  - 36
IP  - 4
DP  - 2011 Aug
TI  - CharlesTaylor, phronesis, and medicine: ethics and interpretation in illness
      narrative.
PG  - 394-409
LID - 10.1093/jmp/jhr032 [doi]
AB  - This paper provides a brief overview and critique of the dominant objectivist
      understanding and use of illness narrative in Enlightenment (scientific) medicine
      and ethics, as well as several revisionist accounts, which reflect the evolution 
      of this approach. In light of certain limitations and difficulties endemic in the
      objectivist understanding of illness narrative, an alternative phronesis approach
      to medical ethics influenced by Charles Taylor's account of the interpretive
      nature of human agency and language is examined. To this end, the account of
      interpretive medical responsibility previously described by Schultz and Carnevale
      as "clinical phronesis" (based upon Taylor's notion of "strong" or "radical
      evaluation") is reviewed and expanded. The thesis of this paper is that illness
      narrative has the ability to benefit patients as well as the potential to cause
      harm or iatrogenic effects. This benefit or harm is contingent upon how the story
      is told and understood. Consequently, these tales are not simply "nice stories," 
      cathartic gestures, or mere supplements to scientific procedures and decision
      making, as suggested by the objectivist approach. Rather, they open the agent to 
      meanings that provide a context for explanation and evaluation of illness
      episodes and therapeutic activities. This understanding provides indicators
      (guides) for right action. Hence, medical responsibility as clinical phronesis
      involves, first, the patient and provider's coformulation and cointerpretation of
      what is going on in the patient's illness narrative, and second, the patient and 
      provider's response to interpretation of the facts of illness and what they
      signify-not simply a response to the brute facts of illness, alone. The appeal to
      medical responsibility as clinical phronesis thus underscores the importance of
      getting the patient's story of illness right. It is anticipated that further
      elaboration concerning the idea of clinical phronesis as interpretive illness
      narrative will provide a new foundation for medical ethics and decision making.
FAU - Schultz, Dawson Stafford
AU  - Schultz DS
AD  - University of California, Santa Cruz, California, USA. schultzphd@msn.com
FAU - Flasher, Lydia Victoria
AU  - Flasher LV
LA  - eng
PT  - Journal Article
DEP - 20110907
PL  - United States
TA  - J Med Philos
JT  - The Journal of medicine and philosophy
JID - 7610512
SB  - IM
MH  - *Communication
MH  - *Ethics, Medical
MH  - Humans
MH  - *Medicine
MH  - *Narration
MH  - Philosophy, Medical
MH  - Professional Role
MH  - Social Sciences
EDAT- 2011/09/09 06:00
MHDA- 2012/02/09 06:00
CRDT- 2011/09/09 06:00
PHST- 2011/09/09 06:00 [entrez]
PHST- 2011/09/09 06:00 [pubmed]
PHST- 2012/02/09 06:00 [medline]
AID - jhr032 [pii]
AID - 10.1093/jmp/jhr032 [doi]
PST - ppublish
SO  - J Med Philos. 2011 Aug;36(4):394-409. doi: 10.1093/jmp/jhr032. Epub 2011 Sep 7.


PMID- 21900342
OWN - NLM
STAT- MEDLINE
DCOM- 20120711
LR  - 20120517
IS  - 1940-1574 (Electronic)
IS  - 0003-3197 (Linking)
VI  - 63
IP  - 5
DP  - 2012 Jul
TI  - The utility of collaborative biobanks for cardiovascular research.
PG  - 367-77
LID - 10.1177/0003319711418958 [doi]
AB  - Differences between animal and human atherosclerosis have led to the requirement 
      for clinical data, imaging information and biological material from large numbers
      of patients and healthy persons. Where such "biobanks" exist, they have been
      fruitful sources for genomewide association, diagnostic accuracy, ethnicity, and 
      risk stratification cohort studies. In addition once established, they attract
      funding for future projects. Biobanks require a network of medical contributors, 
      secure storage facilities, bioinformatics expertise, database managers, and
      ethical working practices to function optimally. There is the opportunity for
      collaboration between individual biobanks to further amplify the advantages
      afforded.
FAU - Shalhoub, Joseph
AU  - Shalhoub J
AD  - Academic Section of Vascular Surgery, Department of Surgery & Cancer, Imperial
      College, London, UK. j.shalhoub@imperial.ac.uk
FAU - Davies, Kerry J
AU  - Davies KJ
FAU - Hasan, Nazeeha
AU  - Hasan N
FAU - Thapar, Ankur
AU  - Thapar A
FAU - Sharma, Pankaj
AU  - Sharma P
FAU - Davies, Alun H
AU  - Davies AH
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110907
PL  - United States
TA  - Angiology
JT  - Angiology
JID - 0203706
SB  - IM
MH  - *Atherosclerosis/diagnosis/ethnology/etiology/genetics
MH  - Biomedical Research/ethics/*organization & administration
MH  - *Cooperative Behavior
MH  - Genome-Wide Association Study
MH  - Humans
MH  - *Interdisciplinary Communication
MH  - Organizational Objectives
MH  - Risk Assessment
MH  - Risk Factors
MH  - Systems Biology
MH  - Tissue Banks/ethics/*organization & administration
EDAT- 2011/09/09 06:00
MHDA- 2012/07/12 06:00
CRDT- 2011/09/09 06:00
PHST- 2011/09/09 06:00 [entrez]
PHST- 2011/09/09 06:00 [pubmed]
PHST- 2012/07/12 06:00 [medline]
AID - 0003319711418958 [pii]
AID - 10.1177/0003319711418958 [doi]
PST - ppublish
SO  - Angiology. 2012 Jul;63(5):367-77. doi: 10.1177/0003319711418958. Epub 2011 Sep 7.


PMID- 21900333
OWN - NLM
STAT- MEDLINE
DCOM- 20120914
LR  - 20211203
IS  - 1460-2407 (Electronic)
IS  - 1360-9947 (Linking)
VI  - 18
IP  - 2
DP  - 2012 Feb
TI  - Uterine transplantation research: laboratory protocols for clinical application.
PG  - 68-78
LID - 10.1093/molehr/gar055 [doi]
AB  - The aim of this review is to summarize the state-of the-art methods that are used
      in clinical organ transplantation today, as well as the major findings of recent 
      experimental uterus transplantation (UTx) research regarding organ
      donation/retrieval, ischemic preservation, surgical techniques for anastomosis,
      immunosuppression and pregnancy. Absolute uterine factor infertility lacks
      treatment despite the major developments in infertility treatment and assisted
      reproduction. Concerning uterine factor infertile patients, genetic motherhood is
      only possible through gestational surrogacy. The latter can pose medical, ethical
      and legal concerns such as lack of control of life habits during surrogate
      pregnancy, economic motives for women to become surrogate mothers,
      medical/psychological pregnancy-related risks of the surrogate mother and
      uncertainties regarding the mother definition. Thus, surrogacy is non-approved in
      large parts of the world. Recent advances in the field of solid organ
      transplantation and experimental UTx provide a favourable and safe background in 
      a scenario in which a human clinical UTx trial can take place. Protocols based on
      animal research over the last decade are described with a view to providing a
      scientifically guided approach to human UTx as an experimental procedure in the
      future.
FAU - Diaz-Garcia, C
AU  - Diaz-Garcia C
AD  - Department of Obstetrics and Gynecology, Sahlgrenska Academy, University of
      Gothenburg, Gothenburg SE-41345, Sweden.
FAU - Johannesson, L
AU  - Johannesson L
FAU - Enskog, A
AU  - Enskog A
FAU - Tzakis, A
AU  - Tzakis A
FAU - Olausson, M
AU  - Olausson M
FAU - Brannstrom, M
AU  - Brannstrom M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110907
PL  - England
TA  - Mol Hum Reprod
JT  - Molecular human reproduction
JID - 9513710
RN  - 0 (Organ Preservation Solutions)
SB  - IM
MH  - Female
MH  - Humans
MH  - Immunosuppression Therapy
MH  - Infertility, Female/surgery/*therapy
MH  - Lymphocyte Depletion
MH  - Organ Preservation Solutions
MH  - Pregnancy
MH  - Reperfusion Injury/prevention & control
MH  - Surrogate Mothers/legislation & jurisprudence
MH  - Tissue and Organ Harvesting/*methods
MH  - Transplantation, Homologous
MH  - Uterine Diseases/surgery/*therapy
MH  - Uterus/immunology/*transplantation
EDAT- 2011/09/09 06:00
MHDA- 2012/09/15 06:00
CRDT- 2011/09/09 06:00
PHST- 2011/09/09 06:00 [entrez]
PHST- 2011/09/09 06:00 [pubmed]
PHST- 2012/09/15 06:00 [medline]
AID - gar055 [pii]
AID - 10.1093/molehr/gar055 [doi]
PST - ppublish
SO  - Mol Hum Reprod. 2012 Feb;18(2):68-78. doi: 10.1093/molehr/gar055. Epub 2011 Sep
      7.


PMID- 21899938
OWN - NLM
STAT- MEDLINE
DCOM- 20120125
LR  - 20111003
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 73
IP  - 8
DP  - 2011 Oct
TI  - "But then i learned...": weight loss surgery patients negotiate surgery
      discourses.
PG  - 1230-7
LID - 10.1016/j.socscimed.2011.07.023 [doi]
AB  - This research explores commonplace discursive depictions of obesity surgery and
      individual patients' reactions to these depictions. Data come from a content
      analysis of weight loss surgery representations in periodical articles (n = 32)
      and open-ended surveys (n = 55) and interviews (n = 44) with surgery patients
      from 34 US states. This study reveals that mainstream periodicals frequently
      stigmatized patients as obesity surgery is cast as (1) medically risky, (2)
      extravagant and (3) an overly easy escape from obesity. Surgery is only portrayed
      as (4) acceptable when multiple other weight loss techniques had been tried
      unsuccessfully. In contrast, interview and survey data show individual patients
      are aware of, yet frequently refute, these surgical stigmas. Findings demonstrate
      the importance of weight loss surgery patients' personal experiences,
      interactions and education in shaping their responses to stigma. Patients view
      themselves as expert insiders who negotiate dominant discourses and,
      consequently, assert that surgery and surgery patients are ethical. Research
      results reveal the importance of perceived expert insider status and interpretive
      practice in managing obesity surgery stigma.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Drew, Patricia
AU  - Drew P
AD  - California State University, Department of Human Development and Women's Studies,
      25800 Carlos Bee Bvld., Hayward, CA 94542-3051, United States.
      patricia.drew@csueastbay.edu
LA  - eng
PT  - Journal Article
DEP - 20110826
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Adult
MH  - Bariatric Surgery/*psychology
MH  - Female
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - *Negotiating
MH  - Obesity/psychology/surgery
MH  - *Physician-Patient Relations
MH  - Self Concept
MH  - *Stereotyping
MH  - United States
MH  - Weight Loss
EDAT- 2011/09/09 06:00
MHDA- 2012/01/26 06:00
CRDT- 2011/09/09 06:00
PHST- 2010/09/16 00:00 [received]
PHST- 2011/07/25 00:00 [revised]
PHST- 2011/07/26 00:00 [accepted]
PHST- 2011/09/09 06:00 [entrez]
PHST- 2011/09/09 06:00 [pubmed]
PHST- 2012/01/26 06:00 [medline]
AID - S0277-9536(11)00489-8 [pii]
AID - 10.1016/j.socscimed.2011.07.023 [doi]
PST - ppublish
SO  - Soc Sci Med. 2011 Oct;73(8):1230-7. doi: 10.1016/j.socscimed.2011.07.023. Epub
      2011 Aug 26.


PMID- 21899895
OWN - NLM
STAT- MEDLINE
DCOM- 20120207
LR  - 20151119
IS  - 0165-1781 (Print)
IS  - 0165-1781 (Linking)
VI  - 190
IP  - 2-3
DP  - 2011 Dec 30
TI  - Preliminary study of Internet addiction and cognitive function in adolescents
      based on IQ tests.
PG  - 275-81
LID - 10.1016/j.psychres.2011.08.006 [doi]
AB  - The potential relationship between Internet addiction and certain cognitive
      function problems has been suggested by several studies. However, few or no
      studies have examined the differences in cognitive functioning between persons
      addicted to the Internet and persons not addicted using a standard
      neuropsychological test. This study screened 253 middle school students and 389
      high school students for Internet addiction and compared 59 Internet-addicted
      students with 43 non-addicted students using an IQ test. The Internet-addicted
      group had comprehension sub-item scores that were significantly lower than those 
      of the non-addicted group. As the comprehension item reflects ethical judgement
      and reality testing, there may be a relationship between Internet addiction and
      weak social intelligence. Earlier onset of Internet addiction and longer
      addiction duration were associated with lower participant performance in areas
      related to attention. As this study is a cross-sectional study, it is not clear
      whether the persons who display weak cognitive functioning are susceptible to
      Internet addiction or if Internet addiction causes cognitive problems. However,
      as brain development remains active during adolescence, the possibility that
      Internet addiction adversely affects the cognitive functioning of adolescents
      cannot be ruled out.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Park, Min-Hyeon
AU  - Park MH
AD  - Department of Psychiatry, The Catholic University of Korea College of Medicine,
      Seoul, South Korea.
FAU - Park, E-Jin
AU  - Park EJ
FAU - Choi, Jeewook
AU  - Choi J
FAU - Chai, Sukhi
AU  - Chai S
FAU - Lee, Ji-Han
AU  - Lee JH
FAU - Lee, Chul
AU  - Lee C
FAU - Kim, Dai-Jin
AU  - Kim DJ
LA  - eng
PT  - Journal Article
DEP - 20110906
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
SB  - IM
MH  - Adolescent
MH  - Analysis of Variance
MH  - Behavior, Addictive/*epidemiology/*psychology
MH  - Cognition/*physiology
MH  - Cross-Sectional Studies
MH  - Depression/diagnosis/epidemiology
MH  - Female
MH  - Humans
MH  - *Intelligence Tests
MH  - *Internet
MH  - Male
MH  - Neuropsychological Tests
MH  - Psychiatric Status Rating Scales
MH  - Surveys and Questionnaires
EDAT- 2011/09/09 06:00
MHDA- 2012/02/09 06:00
CRDT- 2011/09/09 06:00
PHST- 2010/10/26 00:00 [received]
PHST- 2011/08/01 00:00 [revised]
PHST- 2011/08/10 00:00 [accepted]
PHST- 2011/09/09 06:00 [entrez]
PHST- 2011/09/09 06:00 [pubmed]
PHST- 2012/02/09 06:00 [medline]
AID - S0165-1781(11)00578-6 [pii]
AID - 10.1016/j.psychres.2011.08.006 [doi]
PST - ppublish
SO  - Psychiatry Res. 2011 Dec 30;190(2-3):275-81. doi: 10.1016/j.psychres.2011.08.006.
      Epub 2011 Sep 6.


PMID- 21899889
OWN - NLM
STAT- MEDLINE
DCOM- 20120207
LR  - 20111010
IS  - 1873-6386 (Electronic)
IS  - 0160-2527 (Linking)
VI  - 34
IP  - 5
DP  - 2011 Sep-Oct
TI  - How research ethics' protections can contribute to public policy: the case of
      community treatment orders.
PG  - 349-53
LID - 10.1016/j.ijlp.2011.08.007 [doi]
AB  - Though community treatment orders (CTOs) were first used in 1986 in Australia,
      debate about their clinical and ethical merits continues even today. For some,
      the benefits of reduced frequency and duration of involuntary hospitalizations
      are believed to adequately outweigh the harms of restricted liberties in
      community living. For others, however, such benefits are believed to be
      achievable by simply arranging integrated, devoted community resources sans any
      threat of forced re-hospitalization. In response to this enduring controversy,
      this article examines the ethical merits of community orders using a novel
      approach. "Novel" because the examination is based on research ethics and its
      foundational principles. When hospital and community clinicians, family members, 
      consumer/survivors, and advocacy groups discussed the idea of amending Ontario's 
      mental health legislation to permit CTOs in the late 1990s, evidence of their
      effects and efficacy was very limited. Moreover, an order was characterized much 
      like standard pharmacological or medical therapies because the person or an
      appropriate substitute decision maker's consent was necessary to authorize the
      order or make it valid. These two factors prompted this retrospective analysis:
      if CTOs--as a public policy initiative--had been treated like most other
      promising therapies, would any different ethics-related concerns have been raised
      that, in turn, would have benefited the public debate and the legislature's
      decisions? In other words, if respected safeguards that apply to new drugs and
      medical devices had applied to CTOs, would anything have changed?
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Russell, Barbara J
AU  - Russell BJ
AD  - Centre for Addiction and Mental Health, Toronto, Canada, 33 Russell Street,
      Toronto, Ontario, Canada M5S 2S1. barbara_russell@camh.net
LA  - eng
PT  - Journal Article
DEP - 20110906
PL  - Netherlands
TA  - Int J Law Psychiatry
JT  - International journal of law and psychiatry
JID - 7806862
SB  - IM
MH  - Clinical Trials as Topic
MH  - Commitment of Mentally Ill/*legislation & jurisprudence
MH  - Community Mental Health Services
MH  - *Ethics, Research
MH  - Humans
MH  - Informed Consent/legislation & jurisprudence
MH  - Ontario
MH  - *Public Policy
EDAT- 2011/09/09 06:00
MHDA- 2012/02/09 06:00
CRDT- 2011/09/09 06:00
PHST- 2011/09/09 06:00 [entrez]
PHST- 2011/09/09 06:00 [pubmed]
PHST- 2012/02/09 06:00 [medline]
AID - S0160-2527(11)00078-1 [pii]
AID - 10.1016/j.ijlp.2011.08.007 [doi]
PST - ppublish
SO  - Int J Law Psychiatry. 2011 Sep-Oct;34(5):349-53. doi: 10.1016/j.ijlp.2011.08.007.
      Epub 2011 Sep 6.


PMID- 21899230
OWN - NLM
STAT- MEDLINE
DCOM- 20110929
LR  - 20170214
IS  - 0840-4704 (Print)
IS  - 0840-4704 (Linking)
VI  - 24
IP  - 2
DP  - 2011 Summer
TI  - Ethical leadership in action.
PG  - 110-3
FAU - Racette, Ray J
AU  - Racette RJ
AD  - rracette@cchl-ccls.ca
LA  - eng
LA  - fre
PT  - Journal Article
PL  - United States
TA  - Healthc Manage Forum
JT  - Healthcare management forum
JID - 8805307
MH  - Canada
MH  - *Codes of Ethics
MH  - Delivery of Health Care/ethics
MH  - Ethics Committees
MH  - *Leadership
EDAT- 2011/09/09 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/09/09 06:00
PHST- 2011/09/09 06:00 [entrez]
PHST- 2011/09/09 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - 10.1016/j.hcmf.2011.03.004 [doi]
PST - ppublish
SO  - Healthc Manage Forum. 2011 Summer;24(2):110-3. doi: 10.1016/j.hcmf.2011.03.004.


PMID- 21899179
OWN - NLM
STAT- MEDLINE
DCOM- 20111004
LR  - 20190918
IS  - 0042-8450 (Print)
IS  - 0042-8450 (Linking)
VI  - 68
IP  - 7
DP  - 2011 Jul
TI  - [Transvaginal mesh in repair of pelvic organs prolapse as a minimally invasive
      surgical procedure].
PG  - 583-8
AB  - BACKGROUND/AIM: Prolapse of genital organs with or without urinary stress
      incontinention is the most often health problem in the elderly female population 
      tending to increase with ageing. The aim of this study was to assess the
      perioperative complications and short-term outcomes of prolaps repair using
      transvaginal polypropylene mesh (Prolift system, Gynecare, Ethicon, USA).
      METHODS: A retrospective study was conducted evaluating 96 women from September
      2006 to January 2010 who underwent vaginal repair with implatation of a soft mesh
      manufactured by Gynecare, Ethicon, USA. RESULTS: All the patients had a stage 3
      or stage 4 prolapse according to the POP-Q system of ICS. Total mesh was used in 
      12 (13%) patients isolated anterior mesh in 52 (54%) patients and isolated
      posterior mesh in 32 (33%) patients. We reported one intra-operative bladder
      injury and no other serious complications. At 3 months, all 96 patients were
      available for follow-up. Vaginal erosion occured in 9 (9.3%) patients, shrinkage 
      of mesh in 6 (6.2%) patients and de novo urinary incontinence in 5 (5.2%)
      patients. Failure rate was 6.25% (recurrent prolapse stage 3 or 4 even
      asymptomatic). CONCLUSION: Our study suggests that transvaginal polypropylene
      mesh applied with a tension-free technique is a safe and effective method with
      low intraoperative complications and low morbidity rates. However, some
      complications are serious and require highly specialised management.
FAU - Argirovic, Rajka
AU  - Argirovic R
AD  - Klinicki centar Srbije, Institut za ginekologiju i akuserstvo, Beograd, Srbija.
      cvijiceva@yubc.net
FAU - Berisavac, Milica
AU  - Berisavac M
FAU - Likic-Ladevic, Ivana
AU  - Likic-Ladevic I
FAU - Kadija, Sasa
AU  - Kadija S
FAU - Boskovic, Vladimir
AU  - Boskovic V
FAU - Zizic, Vojislav
AU  - Zizic V
LA  - srp
PT  - English Abstract
PT  - Journal Article
PL  - Serbia
TA  - Vojnosanit Pregl
JT  - Vojnosanitetski pregled
JID - 21530700R
RN  - 0 (Polypropylenes)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Gynecologic Surgical Procedures/methods
MH  - Humans
MH  - Intraoperative Complications
MH  - Middle Aged
MH  - Minimally Invasive Surgical Procedures
MH  - Pelvic Organ Prolapse/*surgery
MH  - Polypropylenes
MH  - Postoperative Complications
MH  - *Surgical Mesh
EDAT- 2011/09/09 06:00
MHDA- 2011/10/05 06:00
CRDT- 2011/09/09 06:00
PHST- 2011/09/09 06:00 [entrez]
PHST- 2011/09/09 06:00 [pubmed]
PHST- 2011/10/05 06:00 [medline]
AID - 10.2298/vsp1107583a [doi]
PST - ppublish
SO  - Vojnosanit Pregl. 2011 Jul;68(7):583-8. doi: 10.2298/vsp1107583a.


PMID- 21878012
OWN - NLM
STAT- MEDLINE
DCOM- 20120105
LR  - 20211203
IS  - 1440-1665 (Electronic)
IS  - 1039-8562 (Linking)
VI  - 19 Suppl 1
DP  - 2011 Jul
TI  - Becoming empowered: a grounded theory study of Aboriginal women's agency.
PG  - S26-9
LID - 10.3109/10398562.2011.583040 [doi]
AB  - OBJECTIVE: The study aim was to identify the process underlying the performance
      of agency for urban-dwelling Aboriginal women in contemporary Australian society 
      with a view to promoting social change for Aboriginal people. METHOD: Grounded
      theory methods were used in the conduct of 20 life history narrative interviews
      with Aboriginal women from across fourteen different language groups. RESULTS:
      Analysis identified a specific ecological model of Aboriginal women's
      empowerment, defined as "becoming empowered". "Performing Aboriginality" was
      identified as the core category and encompassed the women's concern for carving
      out a fulfilling life and carrying out their perceived responsibilities as
      Aboriginal women. CONCLUSIONS: While confirming much of the extant literature on 
      empowerment, the analysis also offered unique contributions--a spiritual
      sensibility, cultural competence and an ethics of care and morality. This sheds
      new light on the creative ways in which Aboriginal women "disrupt" discourses and
      create alternate modes of existence. The findings have implications for improving
      quality of life for Aboriginal people by informing the practical development and 
      delivery of social and health policies and programs.
FAU - Bainbridge, Roxanne
AU  - Bainbridge R
AD  - Empowerment Research Program, Cairns, QLD, Australia.
      roxanne.bainbridge@jcu.edu.au
LA  - eng
PT  - Journal Article
PL  - England
TA  - Australas Psychiatry
JT  - Australasian psychiatry : bulletin of Royal Australian and New Zealand College of
      Psychiatrists
JID - 9613603
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Australia
MH  - Cultural Competency/*psychology
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Native Hawaiian or Other Pacific Islander/*psychology
MH  - *Power, Psychological
MH  - *Psychological Theory
MH  - Self Report
MH  - *Urban Population
MH  - Women's Health
EDAT- 2011/09/09 06:00
MHDA- 2012/01/06 06:00
CRDT- 2011/09/01 06:00
PHST- 2011/09/01 06:00 [entrez]
PHST- 2011/09/09 06:00 [pubmed]
PHST- 2012/01/06 06:00 [medline]
AID - 10.3109/10398562.2011.583040 [doi]
PST - ppublish
SO  - Australas Psychiatry. 2011 Jul;19 Suppl 1:S26-9. doi:
      10.3109/10398562.2011.583040.


PMID- 21872117
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20151119
IS  - 1097-6809 (Electronic)
IS  - 0741-5214 (Linking)
VI  - 54
IP  - 3 Suppl
DP  - 2011 Sep
TI  - Conflict of interest issues pertinent to Veterans Affairs Medical Centers.
PG  - 50S-4S
LID - 10.1016/j.jvs.2011.05.110 [doi]
AB  - Conflicts of interest exist when an arrangement potentially exerts inappropriate 
      influence on decision making or professional judgment, or is perceived to do so, 
      and can thus damage the public trust and undermine the integrity of those
      decisions. Concerns regarding financial conflicts of interest in the medical
      arena have reached their height as of late, given that physicians now function in
      a milieu of complex and delicate relationships with pharmaceutical,
      biotechnology, and medical device industries. Even when such relationships do not
      correlate with actual compromise of judgment or patient care, it threatens the
      credibility of both the health care professional and the institution because of
      the social perception of the effect of these relationships. Although most
      institutions in the Western world set forth a code of ethics and
      conflict-of-interest policies to be followed under threat of termination, the
      Veterans Health Administration (VHA) presents itself as a unique environment in
      which conflicts of interest are subject to governmental laws, violation of which 
      may not only result in employment-related discipline, but may be sanctioned by
      civil and criminal penalties. Moreover, these provisions are developed by a
      national authoritative organization rather than being institution-specific
      guidelines. Given that many academic physicians working within the VHA may also
      have a component of their practice in a University setting, it becomes important 
      to understand the differences in policy between these contexts so as not to
      threaten the public trust in the veracity of decisions made and, therefore,
      maintain the integrity of the relationship between physician and patient. This
      article will review aspects of conflict-of-interest policies in the realm of
      research, financial relationships, foreign travel, and vendor contracting that
      are particular to the VHA and make it a unique environment to function in as a
      physician and scientist.
CI  - Copyright (c) 2011 Society for Vascular Surgery. Published by Mosby, Inc. All
      rights reserved.
FAU - Hanna, Jennifer
AU  - Hanna J
AD  - Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.
      jmh3@duke.edu
FAU - Simiele, Ernest
AU  - Simiele E
FAU - Lawson, D Curtis
AU  - Lawson DC
FAU - Tyler, Douglas
AU  - Tyler D
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Vasc Surg
JT  - Journal of vascular surgery
JID - 8407742
SB  - IM
MH  - Codes of Ethics
MH  - *Conflict of Interest/economics/legislation & jurisprudence
MH  - Cooperative Behavior
MH  - Diffusion of Innovation
MH  - Fees and Charges
MH  - Gift Giving
MH  - Government Regulation
MH  - Guidelines as Topic
MH  - *Health Care Sector/economics/ethics/legislation & jurisprudence/standards
MH  - Health Policy
MH  - Humans
MH  - *Interinstitutional Relations
MH  - *Interprofessional Relations/ethics
MH  - Practice Patterns, Physicians'
MH  - *Quality of Health Care/economics/ethics/legislation & jurisprudence/standards
MH  - Scientific Misconduct
MH  - United States
MH  - *United States Department of Veterans Affairs/economics/ethics/legislation &
      jurisprudence/standards
EDAT- 2011/09/09 06:00
MHDA- 2011/10/25 06:00
CRDT- 2011/08/30 06:00
PHST- 2011/03/01 00:00 [received]
PHST- 2011/04/01 00:00 [revised]
PHST- 2011/05/19 00:00 [accepted]
PHST- 2011/08/30 06:00 [entrez]
PHST- 2011/09/09 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
AID - S0741-5214(11)01373-5 [pii]
AID - 10.1016/j.jvs.2011.05.110 [doi]
PST - ppublish
SO  - J Vasc Surg. 2011 Sep;54(3 Suppl):50S-4S. doi: 10.1016/j.jvs.2011.05.110.


PMID- 21872116
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20151119
IS  - 1097-6809 (Electronic)
IS  - 0741-5214 (Linking)
VI  - 54
IP  - 3 Suppl
DP  - 2011 Sep
TI  - Industry and the profession of medicine: balancing appropriate relationships with
      the need for innovation.
PG  - 47S-9S
LID - 10.1016/j.jvs.2011.04.069 [doi]
AB  - Much has been made over the last few years about conflicts of interest in the
      health care community's relationships with industry members, including individual
      physicians, academic medical centers, and professional organizations. Not only
      has the Department of Justice (DOJ) been investigating questionable
      relationships, but House and Senate Oversight Committees have also weighed in on 
      real and perceived conflicts. Most recently, the Physician Payments Sunshine Act 
      of 2010 requires companies to begin recording any physician payments, including
      stock options, research grants, knickknacks, consulting fees, and travel to
      medical conferences that are worth more than ten dollars in 2012 and report them 
      on March 31, 2013. To date, the American College of Cardiology (ACC) has
      developed and instituted one of the most stringent policies in the medical
      community to ensure that support from industry has no influence on any of its
      clinical documents. Furthermore, the need for the ACC's "Principles for
      Relationships with Industry," the organization's guide in nine key operational
      areas, are critical given that, when it comes to industry, properly managed
      partnerships are absolutely essential to maintaining scientific progress in
      cardiology and other specialties. The ACC relies on industry funding to advance
      cardiovascular research, as well as cardiovascular workforce training,
      practitioner diversity, medical education, and life-long learning. Without this
      funding, the ACC's ability to provide meaningful, unbiased education and to
      improve quality of care would be far more limited than that which is currently
      offered to its members and, ultimately, patients. Rather than restricting
      industry funding for such activities, the focus should instead be on transparency
      and actively and appropriately managing industry relationships. Ethical and
      appropriate partnerships with industry can prove beneficial in funding of
      education, research, and quality improvement activities. In addition, they are
      critical in the advancement of the quality of care for patients. The challenge is
      for medical societies to help the media, the public, and policymakers better
      understand the role of industry in promoting research, education, and innovation 
      in medicine.
CI  - Copyright (c) 2011 Society for Vascular Surgery. Published by Mosby, Inc. All
      rights reserved.
FAU - Lewin, Jack
AU  - Lewin J
AD  - American College of Cardiology, Washington, DC 20037, USA. sfairban@acc.org
FAU - Arend, Thomas E Jr
AU  - Arend TE Jr
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Vasc Surg
JT  - Journal of vascular surgery
JID - 8407742
SB  - IM
MH  - Codes of Ethics
MH  - Conflict of Interest
MH  - *Cooperative Behavior
MH  - *Diffusion of Innovation
MH  - Fees and Charges
MH  - Gift Giving
MH  - Government Regulation
MH  - Guidelines as Topic
MH  - *Health Care Sector/economics/ethics/legislation & jurisprudence/standards
MH  - Health Policy
MH  - Humans
MH  - *Interinstitutional Relations
MH  - *Interprofessional Relations/ethics
MH  - Practice Patterns, Physicians'
MH  - *Quality of Health Care/economics/ethics/legislation & jurisprudence/standards
MH  - Scientific Misconduct
EDAT- 2011/09/09 06:00
MHDA- 2011/10/25 06:00
CRDT- 2011/08/30 06:00
PHST- 2011/02/28 00:00 [received]
PHST- 2011/03/23 00:00 [revised]
PHST- 2011/04/30 00:00 [accepted]
PHST- 2011/08/30 06:00 [entrez]
PHST- 2011/09/09 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
AID - S0741-5214(11)01372-3 [pii]
AID - 10.1016/j.jvs.2011.04.069 [doi]
PST - ppublish
SO  - J Vasc Surg. 2011 Sep;54(3 Suppl):47S-9S. doi: 10.1016/j.jvs.2011.04.069.


PMID- 21872115
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20151119
IS  - 1097-6809 (Electronic)
IS  - 0741-5214 (Linking)
VI  - 54
IP  - 3 Suppl
DP  - 2011 Sep
TI  - Industry working with physicians through professional medical associations.
PG  - 41S-6S
LID - 10.1016/j.jvs.2011.04.068 [doi]
AB  - The physician/surgeon's interactions with industry have come under scrutiny in
      recent years for several reasons. Although some think that the professional
      medical association or society may provide an avenue to allow such interactions
      with less risk, there are concerns and challenges for such organizations as it
      relates to ethical and professional norms of their members. This is one surgeon's
      review of some pertinent information regarding what the professional medical
      society provides to its members and what role industry plays in the society's
      ability to provide these benefits. There is an exploration of the risks involved 
      and practical methods to control inherent conflicts of interest involved in this 
      interaction.
CI  - Copyright (c) 2011 Society for Vascular Surgery. Published by Mosby, Inc. All
      rights reserved.
FAU - Dalsing, Michael C
AU  - Dalsing MC
AD  - Indiana University School of Medicine, Indianapolis, IN 46202, USA.
      mdalsing@iupui.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Vasc Surg
JT  - Journal of vascular surgery
JID - 8407742
SB  - IM
CIN - J Vasc Surg. 2012 Feb;55(2):626. PMID: 22264810
MH  - Codes of Ethics
MH  - Conflict of Interest
MH  - *Cooperative Behavior
MH  - Diffusion of Innovation
MH  - Fees and Charges
MH  - Gift Giving
MH  - Government Regulation
MH  - *Health Care Sector/economics/ethics/legislation & jurisprudence/standards
MH  - Health Policy
MH  - Humans
MH  - *Interinstitutional Relations
MH  - *Interprofessional Relations/ethics
MH  - Practice Guidelines as Topic
MH  - Practice Patterns, Physicians'
MH  - *Quality of Health Care/economics/ethics/legislation & jurisprudence/standards
MH  - Scientific Misconduct
MH  - *Societies, Medical/economics/ethics/legislation & jurisprudence/standards
EDAT- 2011/09/09 06:00
MHDA- 2011/10/25 06:00
CRDT- 2011/08/30 06:00
PHST- 2011/01/30 00:00 [received]
PHST- 2011/01/31 00:00 [revised]
PHST- 2011/04/14 00:00 [accepted]
PHST- 2011/08/30 06:00 [entrez]
PHST- 2011/09/09 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
AID - S0741-5214(11)01371-1 [pii]
AID - 10.1016/j.jvs.2011.04.068 [doi]
PST - ppublish
SO  - J Vasc Surg. 2011 Sep;54(3 Suppl):41S-6S. doi: 10.1016/j.jvs.2011.04.068.


PMID- 21872114
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20151119
IS  - 1097-6809 (Electronic)
IS  - 0741-5214 (Linking)
VI  - 54
IP  - 3 Suppl
DP  - 2011 Sep
TI  - The new CMSS code for interactions with companies managing relationships to
      minimize conflicts.
PG  - 34S-40S
LID - 10.1016/j.jvs.2011.05.109 [doi]
AB  - Conflicts of interest in medicine have received significant attention in recent
      years, through the public and professional media, federal and state governments, 
      and through a 2009 report of the Institute of Medicine on Conflict of Interest in
      Medical Research, Education and Practice. The Council of Medical Specialty
      Societies (CMSS) Code for Interactions with Companies was adopted by the CMSS in 
      April 2010. The Code guides specialty societies in the profession of medicine in 
      ethical relationships between societies and the pharmaceutical and medical device
      industries. The Code serves to protect and promote the independence of specialty 
      societies and their leaders in corporate sponsorships, licensing, advertising,
      society meetings, exhibits, educational programs, journals, clinical practice
      guidelines, and research.
CI  - Copyright (c) 2011 Society for Vascular Surgery. Published by Mosby, Inc. All
      rights reserved.
FAU - Kahn, Norman B Jr
AU  - Kahn NB Jr
AD  - Council of Medical Specialty Societies, Chicago, IL 60611, USA. nkahn@cmss.org
FAU - Lichter, Allen S
AU  - Lichter AS
CN  - Council of Medical Specialty Societies
LA  - eng
PT  - Guideline
PT  - Journal Article
PL  - United States
TA  - J Vasc Surg
JT  - Journal of vascular surgery
JID - 8407742
SB  - IM
MH  - Codes of Ethics
MH  - *Conflict of Interest/economics/legislation & jurisprudence
MH  - Cooperative Behavior
MH  - *Diffusion of Innovation
MH  - Fees and Charges
MH  - Gift Giving
MH  - Government Regulation
MH  - Health Care Sector/economics/ethics/legislation & jurisprudence/*standards
MH  - Health Policy
MH  - Humans
MH  - *Interinstitutional Relations
MH  - *Interprofessional Relations/ethics
MH  - Practice Patterns, Physicians'/standards
MH  - Quality of Health Care/economics/ethics/legislation & jurisprudence/*standards
MH  - Scientific Misconduct
MH  - Societies, Medical/economics/ethics/legislation & jurisprudence/*standards
EDAT- 2011/09/09 06:00
MHDA- 2011/10/25 06:00
CRDT- 2011/08/30 06:00
PHST- 2011/02/28 00:00 [received]
PHST- 2011/03/23 00:00 [revised]
PHST- 2011/05/07 00:00 [accepted]
PHST- 2011/08/30 06:00 [entrez]
PHST- 2011/09/09 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
AID - S0741-5214(11)01370-X [pii]
AID - 10.1016/j.jvs.2011.05.109 [doi]
PST - ppublish
SO  - J Vasc Surg. 2011 Sep;54(3 Suppl):34S-40S. doi: 10.1016/j.jvs.2011.05.109.


PMID- 21872113
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20151119
IS  - 1097-6809 (Electronic)
IS  - 0741-5214 (Linking)
VI  - 54
IP  - 3 Suppl
DP  - 2011 Sep
TI  - Managing perceived conflicts of interest while ensuring the continued innovation 
      of medical technology.
PG  - 31S-3S
LID - 10.1016/j.jvs.2011.05.108 [doi]
AB  - If it were not for the ongoing collaboration between vascular surgeons and the
      medical technology industry, many of these advanced treatments used every day in 
      vascular interventional surgery would not exist. The flip side of this coin is
      that these vital relationships create multiple roles for surgeons and must be
      appropriately managed. The dynamic process of innovation, along with factors such
      as product delivery technique refinement, education, testing and clinical trials,
      and product support, all make it necessary for ongoing and close collaboration
      between surgeons and the device industry. This unique relationship sometimes
      leads to the perception of conflicts of interest for physicians, in part because 
      the competing pressures from the multiple, overlapping roles as
      clinician/caregiver/investigator/innovator/customer are significant. To address
      this issue, the Advanced Medical Technology Association (AdvaMed), the nation's
      largest medical technology association representing medical device and
      diagnostics companies, developed a Code of Ethics to guide medical technology
      companies in their interactions with health care professionals. First introduced 
      in 1993, the AdvaMed Code strongly encourages both industry and physicians to
      commit to openness and high ethical standards in the conduct of their business
      interactions. The AdvaMed Code addresses many of the types of interactions that
      can occur between companies and health care professionals, including training,
      consulting agreements, the provision of demonstration and evaluation units, and
      charitable donations. By following the Code, companies send a strong message that
      treatment decisions must always be based on the best interest of the patient.
CI  - Copyright (c) 2011. Published by Mosby, Inc.
FAU - Van Haute, Andrew
AU  - Van Haute A
AD  - AdvaMed, Washington, DC 20004, USA. avanhaute@advamed.org
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Vasc Surg
JT  - Journal of vascular surgery
JID - 8407742
SB  - IM
MH  - Codes of Ethics
MH  - *Conflict of Interest/economics/legislation & jurisprudence
MH  - Cooperative Behavior
MH  - *Diffusion of Innovation
MH  - Fees and Charges
MH  - Gift Giving
MH  - Government Regulation
MH  - Guidelines as Topic
MH  - *Health Care Sector/economics/ethics/legislation & jurisprudence/standards
MH  - Health Policy
MH  - Humans
MH  - *Interinstitutional Relations
MH  - *Interprofessional Relations/ethics
MH  - Perception
MH  - Practice Patterns, Physicians'
MH  - *Quality of Health Care/economics/ethics/legislation & jurisprudence/standards
MH  - Scientific Misconduct
MH  - *Vascular Surgical Procedures/economics/ethics/legislation &
      jurisprudence/standards
EDAT- 2011/09/09 06:00
MHDA- 2011/10/25 06:00
CRDT- 2011/08/30 06:00
PHST- 2011/03/01 00:00 [received]
PHST- 2011/04/05 00:00 [revised]
PHST- 2011/05/07 00:00 [accepted]
PHST- 2011/08/30 06:00 [entrez]
PHST- 2011/09/09 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
AID - S0741-5214(11)01369-3 [pii]
AID - 10.1016/j.jvs.2011.05.108 [doi]
PST - ppublish
SO  - J Vasc Surg. 2011 Sep;54(3 Suppl):31S-3S. doi: 10.1016/j.jvs.2011.05.108.


PMID- 21872112
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20151119
IS  - 1097-6809 (Electronic)
IS  - 0741-5214 (Linking)
VI  - 54
IP  - 3 Suppl
DP  - 2011 Sep
TI  - New paradigms for physician-industry relations: overview and application for SVS 
      members.
PG  - 26S-30S
LID - 10.1016/j.jvs.2011.06.016 [doi]
AB  - Relationships between physicians and their industry partners have ranged from
      spectacular collaborations that produce extraordinary advances in patient care,
      such as endovascular aneurysm repair, to humiliating scandals such as extravagant
      trips and bogus "consulting" agreements resulting in legal actions. It is the
      latter which have led many to call for the end of all physician-industry
      relationships, and the former which mandate their preservation. While these two
      examples are representative of extremes at each end of the spectrum of this
      issue, in reality the majority of physician-industry relationships are far more
      complex, and the line between appropriate and inappropriate, and ethical and
      unethical, is hard to draw. The benefits of our relationships with industry are
      many: partnering to develop new therapies and technologies, educating and
      training physicians around new therapies and technologies, support of continuing 
      medical education (CME), fellowship training, and patient education. The pitfall 
      and danger of this relationship is that support from industry, be it a meal, a
      pen, an educational grant, or flattery, may unduly and inappropriately influence 
      physician decision making around a specific company's product. While it is clear 
      that free trips are not within the realm of proper interaction, what about
      unrestricted educational grants to institutions, or support of CME activities,
      professional society meetings, and new device training? As a result of the
      intense scrutiny of relationships between physicians and industry recently,
      multiple diverse entities (Association of American Medical Colleges, American
      Medical Association, Accreditation Council for Continuing Medical Education,
      professional medical associations, academic medical centers, industry, and
      government) have generated guidelines and policies with very different
      perspectives, reflective of their different missions. These policies range from
      vague and lenient, with only basic limitation of the physician-industry
      relationship, to extremely rigid and strict, with only minimal interaction and
      mission support permitted. Given the many changes in oversight and expectations
      for the relationship between physicians and industry, it is important for
      vascular surgeons to be aware of the background behind these modifications, the
      evidence that they are needed, and the positions of the diverse organizations and
      institutions that have already defined their policies on this issue.
CI  - Copyright (c) 2011 Society for Vascular Surgery. Published by Mosby, Inc. All
      rights reserved.
FAU - Singh, Niten
AU  - Singh N
AD  - Department of Vascular Surgery, Madigan Army Medical Center, Tacoma, Wash., USA.
FAU - Bush, Ruth
AU  - Bush R
FAU - Dalsing, Michael
AU  - Dalsing M
FAU - Shortell, Cynthia K
AU  - Shortell CK
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Vasc Surg
JT  - Journal of vascular surgery
JID - 8407742
SB  - IM
MH  - Codes of Ethics
MH  - Conflict of Interest
MH  - Cooperative Behavior
MH  - Diffusion of Innovation
MH  - Fees and Charges
MH  - Gift Giving
MH  - Government Regulation
MH  - Guidelines as Topic
MH  - *Health Care Sector/economics/ethics/legislation & jurisprudence/standards
MH  - Health Policy
MH  - Humans
MH  - *Interinstitutional Relations
MH  - *Interprofessional Relations/ethics
MH  - Practice Patterns, Physicians'
MH  - *Quality of Health Care/economics/ethics/legislation & jurisprudence/standards
MH  - Scientific Misconduct
MH  - *Societies, Medical/economics/ethics/legislation & jurisprudence/standards
MH  - *Vascular Surgical Procedures/economics/ethics/legislation &
      jurisprudence/standards
EDAT- 2011/09/09 06:00
MHDA- 2011/10/25 06:00
CRDT- 2011/08/30 06:00
PHST- 2011/03/09 00:00 [received]
PHST- 2011/04/14 00:00 [revised]
PHST- 2011/06/06 00:00 [accepted]
PHST- 2011/08/30 06:00 [entrez]
PHST- 2011/09/09 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
AID - S0741-5214(11)01376-0 [pii]
AID - 10.1016/j.jvs.2011.06.016 [doi]
PST - ppublish
SO  - J Vasc Surg. 2011 Sep;54(3 Suppl):26S-30S. doi: 10.1016/j.jvs.2011.06.016.


PMID- 21898188
OWN - NLM
STAT- MEDLINE
DCOM- 20120731
LR  - 20211020
IS  - 0942-0940 (Electronic)
IS  - 0001-6268 (Linking)
VI  - 153
IP  - 11
DP  - 2011 Nov
TI  - Surgical clipping as the preferred treatment for aneurysms of the middle cerebral
      artery.
PG  - 2111-7
LID - 10.1007/s00701-011-1139-6 [doi]
AB  - OBJECTIVE: In recent years the endovascular treatment of intracranial aneurysms
      (coiling) has progressively gained recognition, particularly after the
      publication of the International Subarachnoid Aneurysm Trial (ISAT) in 2002.
      Despite the fact that in ISAT middle cerebral artery (MCA) aneurysms were clearly
      underrepresented, the study is often used as an argument to favor coiling above
      surgery in MCA aneurysms. Taken into account that MCA aneurysms are very well
      accessible for surgery, a contemporary assessment of the benefits of a preferred 
      surgical strategy for MCA aneurysms was performed in a tertiary neurovascular
      referral center. METHODS: A prospectively kept single-center database of 151
      consecutive patients with an MCA aneurysm was reviewed over a 6-year period
      (2001-2006). Long-term follow-up after surgical treatment of a ruptured MCA
      aneurysm was obtained in 74 out of 77 (96%) patients. The outcome was compared
      with relevant series in the literature. RESULTS: After a mean follow-up of 4.7
      years, 59 out of 74 surgically treated patients (80%) with a ruptured MCA
      aneurysm had a good outcome (mRankin 0-2). All patients with an unruptured MCA
      aneurysm also had a good outcome after clipping. This is well-matched with the
      findings of the literature search, and competitive with the endovascular results.
      CONCLUSION: Surgical clipping is recommended as the principal treatment strategy 
      for MCA aneurysms. This is not only ethically defendable in view of the surgical 
      results but also in line with a strategy to maintain surgical experience within
      centralized neurovascular centers.
FAU - van Dijk, J Marc C
AU  - van Dijk JM
AD  - Department of Neurosurgery, University Medical Center Groningen, University of
      Groningen, The Netherlands. jmcvandijk@gmail.com
FAU - Groen, Rob J M
AU  - Groen RJ
FAU - Ter Laan, Mark
AU  - Ter Laan M
FAU - Jeltema, Johanna Rinck
AU  - Jeltema JR
FAU - Mooij, Jan Jacob A
AU  - Mooij JJ
FAU - Metzemaekers, Jan D M
AU  - Metzemaekers JD
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110907
PL  - Austria
TA  - Acta Neurochir (Wien)
JT  - Acta neurochirurgica
JID - 0151000
SB  - IM
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Intracranial Aneurysm/mortality/*surgery
MH  - Male
MH  - Middle Aged
MH  - Middle Cerebral Artery/*surgery
MH  - Prospective Studies
MH  - Retrospective Studies
MH  - Surgical Instruments/*standards
MH  - Time
MH  - Vascular Surgical Procedures/*instrumentation/*methods/mortality
PMC - PMC3197920
EDAT- 2011/09/08 06:00
MHDA- 2012/08/01 06:00
CRDT- 2011/09/08 06:00
PHST- 2010/02/16 00:00 [received]
PHST- 2011/08/19 00:00 [accepted]
PHST- 2011/09/08 06:00 [entrez]
PHST- 2011/09/08 06:00 [pubmed]
PHST- 2012/08/01 06:00 [medline]
AID - 10.1007/s00701-011-1139-6 [doi]
PST - ppublish
SO  - Acta Neurochir (Wien). 2011 Nov;153(11):2111-7. doi: 10.1007/s00701-011-1139-6.
      Epub 2011 Sep 7.


PMID- 21898022
OWN - NLM
STAT- MEDLINE
DCOM- 20120325
LR  - 20211020
IS  - 1432-2218 (Electronic)
IS  - 0930-2794 (Linking)
VI  - 26
IP  - 2
DP  - 2012 Feb
TI  - A single-blind controlled study of electrocautery and ultrasonic scalpel smoke
      plumes in laparoscopic surgery.
PG  - 337-42
LID - 10.1007/s00464-011-1872-1 [doi]
AB  - BACKGROUND: Surgical smoke containing potentially carcinogenic and irritant
      chemicals is an inevitable consequence of intraoperative energized dissection.
      Different energized dissection methods have not been compared directly in human
      laparoscopic surgery or against commonly encountered pollutants. This study
      undertook an analysis of carcinogenic and irritant volatile hydrocarbon
      concentrations in electrocautery and ultrasonic scalpel plumes compared with
      cigarette smoke and urban city air control samples. METHODS: Once ethical
      approval was obtained, gas samples were aspirated from the peritoneal cavity
      after human laparoscopic intraabdominal surgery solely using either
      electrocautery or ultrasonic scalpels. All were adsorbed in Tenax tubes and
      concentrations of carcinogenic or irritant volatile hydrocarbons measured by gas 
      chromatography. The results were compared with cigarette smoke and urban city air
      control samples. The analyzing laboratory was blinded to sample origin. RESULTS: 
      A total of 10 patients consented to intraoperative gas sampling in which only one
      method of energized dissection was used. Six carcinogenic or irritant
      hydrocarbons (benzene, ethylbenzene, styrene, toluene, heptene, and
      methylpropene) were identified in one or more samples. With the exception of
      styrene (P = 0.016), a nonsignificant trend toward lower hydrocarbon
      concentrations was observed with ultrasonic scalpel use. Ultrasonic scalpel
      plumes had significantly lower hydrocarbon concentrations than cigarette smoke,
      with the exception of methylpropene (P = 0.332). No significant difference was
      observed with city air. Electrocautery samples contained significantly lower
      hydrocarbon concentrations than cigarette smoke, with the exception of toluene (P
      = 0.117) and methyl propene (P = 0.914). Except for toluene (P = 0.028), city air
      showed no significant difference. CONCLUSIONS: Both electrocautery and ultrasonic
      dissection are associated with significantly lower concentrations of the most
      commonly detected carcinogenic and irritant hydrocarbons than cigarette smoke. A 
      nonsignificant trend toward lower hydrocarbon concentrations was seen with
      ultrasonic scalpel dissection compared with diathermy. The contamination levels
      in city air were largely comparable with those seen after ultrasonic scalpel use.
      Although hydrocarbon concentrations are low, cumulative exposures may increase
      health risks. Where concerns arise, ultrasonic scalpel dissection may be
      preferable.
FAU - Fitzgerald, J Edward F
AU  - Fitzgerald JE
AD  - Colorectal Surgery Unit, The Royal Marsden Hospital, London, SW3 6JJ, UK.
      edwardfitzgerald@doctors.org.uk
FAU - Malik, Momin
AU  - Malik M
FAU - Ahmed, Irfan
AU  - Ahmed I
LA  - eng
PT  - Comparative Study
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110905
PL  - Germany
TA  - Surg Endosc
JT  - Surgical endoscopy
JID - 8806653
RN  - 0 (Air Pollutants)
RN  - 0 (Gases)
RN  - 0 (Hazardous Substances)
RN  - 0 (Hydrocarbons)
RN  - 0 (Smoke)
RN  - 0 (Tobacco Smoke Pollution)
SB  - IM
MH  - Air Pollutants/analysis
MH  - Electrocoagulation/*adverse effects/instrumentation
MH  - Gases/analysis
MH  - Hazardous Substances/*analysis
MH  - Humans
MH  - Hydrocarbons/*analysis
MH  - Laparoscopy/*adverse effects
MH  - Single-Blind Method
MH  - Smoke/*analysis
MH  - Surgical Instruments
MH  - Tobacco Smoke Pollution/analysis
MH  - Ultrasonic Surgical Procedures/*adverse effects/instrumentation
EDAT- 2011/09/08 06:00
MHDA- 2012/03/27 06:00
CRDT- 2011/09/08 06:00
PHST- 2011/05/06 00:00 [received]
PHST- 2011/08/01 00:00 [accepted]
PHST- 2011/09/08 06:00 [entrez]
PHST- 2011/09/08 06:00 [pubmed]
PHST- 2012/03/27 06:00 [medline]
AID - 10.1007/s00464-011-1872-1 [doi]
PST - ppublish
SO  - Surg Endosc. 2012 Feb;26(2):337-42. doi: 10.1007/s00464-011-1872-1. Epub 2011 Sep
      5.


PMID- 21897882
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 2229-5488 (Electronic)
IS  - 2229-3485 (Linking)
VI  - 2
IP  - 3
DP  - 2011 Jul
TI  - Perception of various stakeholders regarding clinical drug trial industry in
      India.
PG  - 86-9
LID - 10.4103/2229-3485.83225 [doi]
AB  - CONTEXT: Though India has been thought to be an ideal destination for conduct of 
      clinical drug trials, other smaller countries seem to be doing better. The pace
      of growth observed during 2005-2009 seems to be plateaued in 2010. AIMS: There is
      an urgent need for introspection and corrective actions. MATERIALS AND METHODS:
      An online survey was conducted among various stakeholders from clinical drug
      trial industry in India regarding their perception about clinical drug trial
      industry in India. Respondents were requested to rate training of investigator
      sites, industry, performance of regulatory, etc. RESULTS: Majority of respondent 
      felt that the clinical drug trial industry in India is growing, though India is
      not utilizing its full potential. Lack of trained investigators and delay in
      regulatory approvals came out as biggest hurdles. CONCLUSIONS: Urgent steps need 
      to be taken in terms of proper training of all stakeholders. Regulatory bodies
      ought to bring about some radical changes in the system so as to match the other 
      competing nations.
FAU - Parikh, Rakesh M
AU  - Parikh RM
AD  - Principal Investigator, Unnati Tower, Vidhyadhar Nagar, Jaipur, India.
FAU - Pandia, Kirti
AU  - Pandia K
FAU - Goyal, Mahesh
AU  - Goyal M
FAU - Sharma, Meenakshi
AU  - Sharma M
FAU - Dolima, M S
AU  - Dolima MS
LA  - eng
PT  - Journal Article
PL  - India
TA  - Perspect Clin Res
JT  - Perspectives in clinical research
JID - 101551517
PMC - PMC3159214
OTO - NOTNLM
OT  - Clinical drug trials in India
OT  - ethical issues
OT  - hurdles in clinical drug trials
OT  - investigator training
OT  - regulatory delay
EDAT- 2011/09/08 06:00
MHDA- 2011/09/08 06:01
CRDT- 2011/09/08 06:00
PHST- 2011/09/08 06:00 [entrez]
PHST- 2011/09/08 06:00 [pubmed]
PHST- 2011/09/08 06:01 [medline]
AID - 10.4103/2229-3485.83225 [doi]
AID - PCR-2-86 [pii]
PST - ppublish
SO  - Perspect Clin Res. 2011 Jul;2(3):86-9. doi: 10.4103/2229-3485.83225.


PMID- 21897640
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130704
LR  - 20220331
IS  - 0974-925X (Electronic)
IS  - 0974-7788 (Linking)
VI  - 2
IP  - 1
DP  - 2011 Jan
TI  - The effect of Triphala and Chlorhexidine mouthwash on dental plaque, gingival
      inflammation, and microbial growth.
PG  - 29-36
LID - 10.4103/0974-7788.83188 [doi]
AB  - The objective of this study was to ascertain the effects of a mouthwash prepared 
      with Triphala on dental plaque, gingival inflammation, and microbial growth and
      compare it with commercially available Chlorhexidine mouthwash. This study was
      conducted after ethics committee approval and written consent from guardians (and
      assent from the children) were obtained. A total of 1431 students in the age
      group 8-12 years, belonging to classes fourth to seventh, were the subjects for
      this study. The Knowledge, Attitude and Practice (KAP) of the subjects was
      determined using a questionnaire. The students were divided into three groups
      namely, Group I (n = 457) using Triphala mouthwash (0.6%), Group II (n = 440)
      using Chlorhexidine mouthwash (0.1%) (positive control), and Group III (n = 412) 
      using distilled water (negative control). The assessment was carried out on the
      basis of plaque scores, gingival scores, and the microbiological analysis
      (Streptococcus and lactobacilli counts). Statistical analysis for plaque and
      gingival scores was conducted using the paired sample t-test (for intragroup) and
      the Tukey's test (for intergroup conducted along with analysis of variance test).
      For the Streptococcus mutans and Lactobacillus counts, Wilcoxon and Mann-Whitney 
      test were applied for intragroup and intergroup comparison, respectively. All the
      tests were carried out using the SPSS software. Both the Group I and Group II
      showed progressive decrease in plaque scores from baseline to the end of 9
      months; however, for Group III increase in plaque scores from the baseline to the
      end of 9 months was noted. Both Group I and Group II showed similar effect on
      gingival health. There was inhibitory effect on microbial counts except
      Lactobacillus where Triphala had shown better results than Chlorhexidine. It was 
      concluded that there was no significant difference between the Triphala and the
      Chlorhexidine mouthwash.
FAU - Bajaj, Neeti
AU  - Bajaj N
AD  - Department of Pedodontics and Preventive Dentistry, PDM Dental College and
      Research Institute, Bahadurgarh, Haryana, India.
FAU - Tandon, Shobha
AU  - Tandon S
LA  - eng
PT  - Journal Article
PL  - India
TA  - Int J Ayurveda Res
JT  - International journal of Ayurveda research
JID - 101527491
PMC - PMC3157106
OTO - NOTNLM
OT  - Chlorhexidine
OT  - Triphala
OT  - dental plaque
OT  - gingival inflammation
OT  - microbial growth
EDAT- 2011/09/08 06:00
MHDA- 2011/09/08 06:01
CRDT- 2011/09/08 06:00
PHST- 2011/06/07 00:00 [received]
PHST- 2011/01/25 00:00 [accepted]
PHST- 2011/09/08 06:00 [entrez]
PHST- 2011/09/08 06:00 [pubmed]
PHST- 2011/09/08 06:01 [medline]
AID - 10.4103/0974-7788.83188 [doi]
AID - IJAR-2-29 [pii]
PST - ppublish
SO  - Int J Ayurveda Res. 2011 Jan;2(1):29-36. doi: 10.4103/0974-7788.83188.


PMID- 21897599
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1998-3565 (Electronic)
IS  - 0973-6247 (Linking)
VI  - 5
IP  - 2
DP  - 2011 Jul
TI  - The quest for an Indian blood law as of blood transfusion services regulatory
      framework.
PG  - 171-4
LID - 10.4103/0973-6247.83246 [doi]
AB  - BACKGROUND: Blood transfusion services are a vital part of the national health
      delivery system. The responsibility for ensuring a continuous supply of blood
      rests with health administrators, who need to galvanize entire communities
      towards regular and non-remunerated blood donation. OBJECTIVE: The present study 
      aimed to examine the prevailing global regulations and practices related to blood
      transfusion and press the case for a dedicated blood law in India. MATERIALS AND 
      METHODS: We attempted a comprehensive, annotated assembly of published studies on
      blood transfusion services in India. DATA ABSTRACTION AND SYNTHESIS: Laws related
      to blood transfusion services exist in India as a part of the Drugs and Cosmetics
      Law. In the developed world, most blood donors are unpaid volunteers who give
      blood for a community supply. In order to augment safe blood transfusion services
      in India, we have to develop operational legal guidelines on recruitment and
      retention of voluntary blood donors to direct related organizations for this
      imperative activity. CONCLUSION: Several factors, such as political will and a
      professional and ethical approach can help in formulating a common vision,
      building trust, by providing optimum information towards a social movement for
      the rational blood transfusion services. We have to come together for a dedicated
      blood law in order to improve the quality of blood transfusion services in India.
FAU - Pal, Ranabir
AU  - Pal R
AD  - Department of Community Medicine, Sikkim Manipal Institute of Medical Sciences
      (SMIMS) and Central Referral Hospital (CRH), 5 Mile, Tadong, Gangtok, Sikkim,
      India.
FAU - Kar, Sumit
AU  - Kar S
FAU - Zaman, Forhad Akhtar
AU  - Zaman FA
FAU - Pal, Shrayan
AU  - Pal S
LA  - eng
PT  - Journal Article
PL  - India
TA  - Asian J Transfus Sci
JT  - Asian journal of transfusion science
JID - 101306858
PMC - PMC3159250
OTO - NOTNLM
OT  - Blood law
OT  - Drugs and Cosmetics Act India
OT  - India
EDAT- 2011/09/08 06:00
MHDA- 2011/09/08 06:01
CRDT- 2011/09/08 06:00
PHST- 2011/09/08 06:00 [entrez]
PHST- 2011/09/08 06:00 [pubmed]
PHST- 2011/09/08 06:01 [medline]
AID - 10.4103/0973-6247.83246 [doi]
AID - AJTS-5-171 [pii]
PST - ppublish
SO  - Asian J Transfus Sci. 2011 Jul;5(2):171-4. doi: 10.4103/0973-6247.83246.


PMID- 21896833
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20110907
IS  - 1555-905X (Electronic)
IS  - 1555-9041 (Linking)
VI  - 6
IP  - 9
DP  - 2011 Sep
TI  - Ethical principles and processes guiding dialysis decision-making.
PG  - 2313-7
LID - 10.2215/CJN.03960411 [doi]
AB  - When the US Congress created the End-Stage Renal Disease (ESRD) Program in 1972, 
      it gave physicians the responsibility of determining which patients were
      "appropriate" for dialysis. Congress provided no guidance on who should be
      selected or how. Only five years later, Dr. Belding Scribner, the father of
      chronic dialysis, noted that there was a need for a "deselection committee"
      because virtually all criteria for dialysis patient selection had been slackened,
      if not abandoned. In 1991, the Institute of Medicine Committee to Study the
      Medicare ESRD Program recommended the development of a clinical practice
      guideline because they noted there were "an increasing number of [dialysis]
      patients with limited survival possibilities and relatively poor quality of
      life." In 2000, the Renal Physicians Association and the American Society of
      Nephrology heeded the Institute of Medicine committee's recommendation and
      published Shared Decision-Making in the Appropriate Initiation of and Withdrawal 
      from Dialysis. In 2010, prompted by a substantial body of new research evidence, 
      the Renal Physicians Association published a second edition of this clinical
      practice guideline. This article describes the application of the ethical
      principles of respect for patient autonomy, beneficence, nonmaleficence, justice,
      and professional integrity, and the ethical process of shared decision-making in 
      making decisions about starting, withholding, continuing, and stopping dialysis
      with patients and families. It urges examination of medical indications and
      identifies appropriate limits to shared decision-making when the burdens of
      dialysis can be predicted to substantially outweigh the benefits.
FAU - Moss, Alvin H
AU  - Moss AH
AD  - Section of Nephrology,West Virginia University School of Medicine, and Center for
      Health Ethics and Law, Robert C. Byrd Health Sciences Center,West Virginia
      University, Morgantown, WV, USA. amoss@hsc.wvu.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin J Am Soc Nephrol
JT  - Clinical journal of the American Society of Nephrology : CJASN
JID - 101271570
SB  - IM
MH  - Decision Making/*ethics
MH  - Family
MH  - Humans
MH  - *Practice Guidelines as Topic
MH  - Quality of Life
MH  - Renal Dialysis/*ethics/psychology
EDAT- 2011/09/08 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/09/08 06:00
PHST- 2011/09/08 06:00 [entrez]
PHST- 2011/09/08 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - 6/9/2313 [pii]
AID - 10.2215/CJN.03960411 [doi]
PST - ppublish
SO  - Clin J Am Soc Nephrol. 2011 Sep;6(9):2313-7. doi: 10.2215/CJN.03960411.


PMID- 21896832
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20110907
IS  - 1555-905X (Electronic)
IS  - 1555-9041 (Linking)
VI  - 6
IP  - 9
DP  - 2011 Sep
TI  - Better off living--the ethics of the new UNOS proposal for allocating kidneys for
      transplantation.
PG  - 2310-2
LID - 10.2215/CJN.03310411 [doi]
FAU - Reese, Peter P
AU  - Reese PP
AD  - Renal Division, Department of Medicine, University of Pennsylvania, Philadelphia,
      Pennsylvania 19104, USA. peter.reese@uphs.upenn.edu
FAU - Caplan, Arthur L
AU  - Caplan AL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin J Am Soc Nephrol
JT  - Clinical journal of the American Society of Nephrology : CJASN
JID - 101271570
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Humans
MH  - Kidney Transplantation/*ethics/mortality
MH  - Living Donors
MH  - Middle Aged
MH  - Resource Allocation/*ethics
MH  - Tissue and Organ Procurement/*ethics
MH  - Waiting Lists
EDAT- 2011/09/08 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/09/08 06:00
PHST- 2011/09/08 06:00 [entrez]
PHST- 2011/09/08 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - 6/9/2310 [pii]
AID - 10.2215/CJN.03310411 [doi]
PST - ppublish
SO  - Clin J Am Soc Nephrol. 2011 Sep;6(9):2310-2. doi: 10.2215/CJN.03310411.


PMID- 21896521
OWN - NLM
STAT- MEDLINE
DCOM- 20111214
LR  - 20170521
IS  - 1931-3543 (Electronic)
IS  - 0012-3692 (Linking)
VI  - 140
IP  - 3
DP  - 2011 Sep
TI  - The law and its interaction with medical ethics in end-of-life decision making.
PG  - 775-780
LID - S0012-3692(11)60486-8 [pii]
LID - 10.1378/chest.10-1612 [doi]
AB  - The previous two articles in this series explored the historical and theoretical 
      development of medical decision making from initial reliance on medical
      beneficence to a more recent emphasis on patient autonomy. The law of withholding
      and withdrawal of treatment has much in common with medical ethics. It is based
      on concerns about patient autonomy expressed by courts, legislatures, and the
      executive branch of the government. Legally, the patient's right of
      self-determination has been based on a variety of sources ranging from state and 
      federal constitutions to the common law of torts and from cases to statutes and
      regulations. Understanding the various sources of the law, the distinctions among
      those sources, and the interaction of the branches of government in this context 
      assists in understanding the law itself. In our federalist system of government, 
      significant legal variations can exist among the states, but although technically
      valid, excessive concern about compliance with the precise contours of each
      state's statute when surrogate decision makers are engaging in bedside
      deliberations is unnecessary. Regardless of source or precise legal contours, the
      overall goal, which neither the physician nor the patient's surrogate or proxy
      decision makers should forget, is to honor what the patient would want to have
      done. Physicians and attorneys will agree on that as a matter of both ethics and 
      the law.
FAU - Cerminara, Kathy L
AU  - Cerminara KL
AD  - Shepard Broad Law Center, Nova Southeastern University, Ft Lauderdale, FL.
      Electronic address: cerminarak@nsu.law.nova.edu.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Chest
JT  - Chest
JID - 0231335
SB  - IM
MH  - Beneficence
MH  - Decision Making/*ethics
MH  - *Ethics, Medical
MH  - Humans
MH  - *Legislation, Medical
MH  - Mental Competency/legislation & jurisprudence
MH  - Personal Autonomy
MH  - Terminal Care/*ethics/*legislation & jurisprudence
MH  - Treatment Refusal/ethics
MH  - United States
EDAT- 2011/09/08 06:00
MHDA- 2011/12/15 06:00
CRDT- 2011/09/08 06:00
PHST- 2011/09/08 06:00 [entrez]
PHST- 2011/09/08 06:00 [pubmed]
PHST- 2011/12/15 06:00 [medline]
AID - S0012-3692(11)60486-8 [pii]
AID - 10.1378/chest.10-1612 [doi]
PST - ppublish
SO  - Chest. 2011 Sep;140(3):775-780. doi: 10.1378/chest.10-1612.


PMID- 21896294
OWN - NLM
STAT- MEDLINE
DCOM- 20120307
LR  - 20161125
IS  - 1095-8304 (Electronic)
IS  - 0195-6663 (Linking)
VI  - 57
IP  - 3
DP  - 2011 Dec
TI  - Eating green. Consumers' willingness to adopt ecological food consumption
      behaviors.
PG  - 674-82
LID - 10.1016/j.appet.2011.08.010 [doi]
AB  - Food consumption is associated with various environmental impacts, and consumers'
      food choices therefore represent important environmental decisions. In a
      large-scale survey, we examined consumers' beliefs about ecological food
      consumption and their willingness to adopt such behaviors. Additionally, we
      investigated in more detail how different motives and food-related attitudes
      influenced consumers' willingness to reduce meat consumption and to buy seasonal 
      fruits and vegetables. We found consumers believed avoiding excessive packaging
      had the strongest impact on the environment, whereas they rated purchasing
      organic food and reducing meat consumption as least environmentally beneficial.
      Similarly, respondents appeared to be most unwilling to reduce meat consumption
      and purchase organic food. Taste and environmental motives influenced consumers' 
      willingness to eat seasonal fruits and vegetables, whereas preparedness to reduce
      meat consumption was influenced by health and ethical motives. Women and
      respondents who preferred natural foods were more willing to adopt ecological
      food consumption patterns.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Tobler, Christina
AU  - Tobler C
AD  - ETH Zurich, Institute of Environmental Decisions, Consumer Behavior,
      Universitaetstrasse 16, CHN J 75.2, 8092 Zurich, Switzerland.
FAU - Visschers, Vivianne H M
AU  - Visschers VH
FAU - Siegrist, Michael
AU  - Siegrist M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110827
PL  - England
TA  - Appetite
JT  - Appetite
JID - 8006808
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Choice Behavior
MH  - *Conservation of Natural Resources
MH  - *Feeding Behavior
MH  - Female
MH  - *Food Preferences
MH  - Food, Organic
MH  - Fruit
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Meat
MH  - Middle Aged
MH  - Odds Ratio
MH  - Regression Analysis
MH  - Socioeconomic Factors
MH  - Surveys and Questionnaires
MH  - Switzerland
MH  - Taste
MH  - Vegetables
MH  - Young Adult
EDAT- 2011/09/08 06:00
MHDA- 2012/03/08 06:00
CRDT- 2011/09/08 06:00
PHST- 2011/07/21 00:00 [received]
PHST- 2011/08/18 00:00 [revised]
PHST- 2011/08/21 00:00 [accepted]
PHST- 2011/09/08 06:00 [entrez]
PHST- 2011/09/08 06:00 [pubmed]
PHST- 2012/03/08 06:00 [medline]
AID - S0195-6663(11)00554-X [pii]
AID - 10.1016/j.appet.2011.08.010 [doi]
PST - ppublish
SO  - Appetite. 2011 Dec;57(3):674-82. doi: 10.1016/j.appet.2011.08.010. Epub 2011 Aug 
      27.


PMID- 21895495
OWN - NLM
STAT- MEDLINE
DCOM- 20120716
LR  - 20161125
IS  - 1937-3392 (Electronic)
IS  - 1937-3384 (Linking)
VI  - 17
IP  - 12
DP  - 2011 Dec
TI  - Bone tissue engineering in oral surgery: a new method of bone development in
      periodontal surgery.
PG  - 1179-87
LID - 10.1089/ten.tec.2011.0213 [doi]
AB  - This article describes the development of a new surgical approach to periodontal 
      treatment. Twenty patients who suffered from bone defects without existing bony
      walls due to adult periodontitis were treated in three different groups using
      methods of bone tissue engineering. At that time no surgical technique existed
      that could be applied to those patients to generate new bone. The periodontal
      surgeries were performed between 2004 and 2008. All patients received follow-up
      examinations at 6, 12, and 24 months after surgical procedure. Measured
      parameters were compared to baseline. The surgical approach and the augmentation 
      material have been improved based on the results of the previous group. This
      strategy was applied because of the ethical fact that a medical treatment of
      patients has to be carried out with the knowledge and experience of previous
      settings. All groups received recombinant human bone morphogenetic protein 2 and 
      platelet-rich plasma. The above-mentioned procedure had been approved in other
      indications in the field of oral and maxillofacial surgery. The first group
      underwent conventional muco-periosteal flap technique and obtained an
      augmentation with absorbable collagen sponge (ACS). The second and third groups
      were treated using endoscopically assisted microsurgery due to wound healing
      disturbances that appeared in the first group. The augmentation was carried out
      with demineralized bone matrix (DBM) instead of ACS (group 2) or
      tricalciumphosphate as a further development instead of DBM (group 3). The
      radiological control 12 months (group 1), 18 months (group 2), and 2 years (group
      3) after surgery proved the following results-first group: 1.7 mm (average)
      vertical bone development (VBD); second group: 2.5 mm (average) VBD; third group:
      3.2 mm (average) VBD. These results of single patient treatment open new ways
      into periodontal surgery. They have to be confirmed by prospective case series
      and multicenter studies.
FAU - Schuckert, Karl-Heinz
AU  - Schuckert KH
AD  - Institute Indente-Institute of Innovative Oral Surgery and Medicine, Centre for
      Tissue Engineering, Hannover, Germany. k-h.schuckert@indente.de
FAU - Osadnik, Magdalena
AU  - Osadnik M
LA  - eng
PT  - Journal Article
DEP - 20110906
PL  - United States
TA  - Tissue Eng Part C Methods
JT  - Tissue engineering. Part C, Methods
JID - 101466663
SB  - IM
MH  - Adult
MH  - Aged
MH  - Bone Development/*physiology
MH  - Bone and Bones/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oral Surgical Procedures/*methods
MH  - Periodontium/diagnostic imaging/*surgery
MH  - Preoperative Care
MH  - Radiography
MH  - Tissue Engineering/*methods
EDAT- 2011/09/08 06:00
MHDA- 2012/07/17 06:00
CRDT- 2011/09/08 06:00
PHST- 2011/09/08 06:00 [entrez]
PHST- 2011/09/08 06:00 [pubmed]
PHST- 2012/07/17 06:00 [medline]
AID - 10.1089/ten.tec.2011.0213 [doi]
PST - ppublish
SO  - Tissue Eng Part C Methods. 2011 Dec;17(12):1179-87. doi:
      10.1089/ten.tec.2011.0213. Epub 2011 Sep 6.


PMID- 21894872
OWN - NLM
STAT- MEDLINE
DCOM- 20110920
LR  - 20151119
IS  - 1548-8578 (Print)
IS  - 1548-8578 (Linking)
VI  - 32
IP  - 6
DP  - 2011 Jul-Aug
TI  - The rise in prescription drug abuse: raising awareness in the dental community.
PG  - 14-6, 18-22; quiz 24, 36
AB  - Prescription drugs classified as controlled dangerous substances are essential
      therapeutic modalities in treating a variety of healthcare conditions; however,
      their pleasurable side effects can appeal to patients for uses other than their
      intent. As a result, unfortunate consequences of prescription drug use can arise.
      Misuse or abuse of prescription drugs can contribute to addictive behaviors,
      serious health risks, and potentially, death. It is imperative that the dental
      community remains educated and informed of nationwide healthcare trends, and
      prescription drug abuse is no exception. Ethically, dentists should be able to
      respond in a manner that addresses the best interests of their patients. To
      respond appropriately, dentists need to understand the terminology of
      prescription drug abuse; be able to identify and describe the drugs most often
      misused or abused; be able to identify individuals who may be at risk for
      prescription drug abuse; and be prepared to manage patients at risk in the dental
      setting.
FAU - Oakley, Marnie
AU  - Oakley M
AD  - University of Pittsburgh, School of Dental Medicine, Pittsburgh, Pennsylvania,
      USA.
FAU - O'Donnell, Jean
AU  - O'Donnell J
FAU - Moore, Paul A
AU  - Moore PA
FAU - Martin, James
AU  - Martin J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Compend Contin Educ Dent
JT  - Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995)
JID - 9600713
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Central Nervous System Depressants)
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Prescription Drugs)
MH  - Analgesics, Opioid
MH  - Central Nervous System Depressants
MH  - Central Nervous System Stimulants
MH  - Drug and Narcotic Control
MH  - Humans
MH  - Practice Patterns, Dentists'
MH  - *Prescription Drugs/classification
MH  - *Substance-Related Disorders
MH  - Terminology as Topic
EDAT- 2011/09/08 06:00
MHDA- 2011/09/21 06:00
CRDT- 2011/09/08 06:00
PHST- 2011/09/08 06:00 [entrez]
PHST- 2011/09/08 06:00 [pubmed]
PHST- 2011/09/21 06:00 [medline]
PST - ppublish
SO  - Compend Contin Educ Dent. 2011 Jul-Aug;32(6):14-6, 18-22; quiz 24, 36.


PMID- 21894642
OWN - NLM
STAT- MEDLINE
DCOM- 20111121
LR  - 20141120
IS  - 1132-1989 (Print)
IS  - 1132-1989 (Linking)
VI  - 22
IP  - 74
DP  - 2011 Jan-Apr
TI  - [Ethical dilemmas in the medical practice in 2010: reflexions around the results 
      of a survey to 10,000 physicians].
PG  - 113-8
FAU - Bosch-Barrera, Joaquim
AU  - Bosch-Barrera J
AD  - Departamento de Oncologia, Hospital Universitario Doctor Josep Trueta, Instituto 
      Catalan de Oncologia de Girona, Avenida de Francia s/n - Girona.
      jbosch@iconcologia.net
LA  - spa
PT  - Journal Article
TT  - Dilemas eticos en la practica medica en 2010: reflexiones en torno a los
      resultados de una encuesta a mas de 10.000 facultativos.
PL  - Spain
TA  - Cuad Bioet
JT  - Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y
      Etica Medica
JID - 101312976
SB  - IM
MH  - Attitude of Health Personnel
MH  - *Bioethical Issues
MH  - *Data Collection/statistics & numerical data
MH  - *Ethics, Medical
MH  - Global Health
MH  - Humans
MH  - Internet
MH  - Medicine
MH  - Physician-Patient Relations/ethics
MH  - Physicians/*statistics & numerical data
MH  - Professional Practice/ethics
MH  - United States
EDAT- 2011/09/08 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/09/08 06:00
PHST- 2011/09/08 06:00 [entrez]
PHST- 2011/09/08 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PST - ppublish
SO  - Cuad Bioet. 2011 Jan-Apr;22(74):113-8.


PMID- 21894410
OWN - NLM
STAT- MEDLINE
DCOM- 20120419
LR  - 20220330
VI  - 26
IP  - 2
DP  - 2011 Apr-Jun
TI  - Brazilian perfusionists and arterial roller pump adjustment: comparison between
      static and dynamic calibration method.
PG  - 205-12
LID - S0102-76382011000200010 [pii]
AB  - INTRODUCTION: Roller pumps play an important role in extracorporeal circulation. 
      However, occlusion of the rollers should be adequately performed and this can be 
      adjusted mainly by two methods: static and dynamic. OBJECTIVE: To investigate how
      the Brazilian perfusionists adjust arterial roller pumps in their services and
      evaluate the application of a Device to Assist Calibration (DAC) that facilitates
      roller adjustment by the dynamic calibration method. METHODS: We installed a
      roller pump with accessories to perform adjustment by drop rate (static
      calibration) and dynamic calibration methods during the XXVIII Brazilian Congress
      of Extracorporeal Circulation. Perfusionists were asked to adjust the roller pump
      according to the procedure they usually do in their service. After each
      adjustment pressure was measured by dynamic calibration method with DAC. The
      research was approved by the Research Ethics Committee of UNICAMP, N masculine
      1144/2010. RESULTS: There were 56 perfusionists in this study. Pressure average
      of 56 measurements of dynamic calibration was 434 +/- 214 mmHg; 76% of
      measurements were within the recommended range for the use of the dynamic
      calibration method (between 150 and 500 mmHg). CONCLUSION: Brazilian
      perfusionists tend to adjust roller pumps with less occlusive settings. The
      amplitudes of the dynamic calibration pressure tend to be smaller for more
      experienced perfusionists because their skills increase with time. The device can
      be used by the perfusionist to adjust roller pumps with greater accuracy and
      mainly repeatability in few minutes.
FAU - Vieira Junior, Francisco Ubaldo
AU  - Vieira Junior FU
AD  - Center for Biomedical Engineering (CEB / UNICAMP), Department of Biomedical
      Engineering (DEB/FEEC/UNICAMP) SP, Brasil. ubaldo@ceb.unicamp.br
FAU - Antunes, Nilson
AU  - Antunes N
FAU - Medeiros Junior, Johannes Dantas de
AU  - Medeiros Junior JD
FAU - Vieira, Reinaldo Wilson
AU  - Vieira RW
FAU - Carvalho Filho, Elio Barreto de
AU  - Carvalho Filho EB
FAU - Reis Junior, Jose Evaldo Cavalcante
AU  - Reis Junior JE
FAU - Costa, Eduardo Tavares
AU  - Costa ET
LA  - eng
LA  - por
PT  - Comparative Study
PT  - Journal Article
PL  - Brazil
TA  - Rev Bras Cir Cardiovasc
JT  - Revista brasileira de cirurgia cardiovascular : orgao oficial da Sociedade
      Brasileira de Cirurgia Cardiovascular
JID - 9104279
SB  - IM
MH  - Adult
MH  - Allied Health Occupations
MH  - Calibration
MH  - Extracorporeal Circulation/*instrumentation
MH  - Female
MH  - Humans
MH  - Infusion Pumps/*standards
MH  - Male
MH  - Middle Aged
MH  - Young Adult
EDAT- 2011/09/07 06:00
MHDA- 2012/04/20 06:00
CRDT- 2011/09/07 06:00
PHST- 2011/01/26 00:00 [received]
PHST- 2011/04/07 00:00 [accepted]
PHST- 2011/09/07 06:00 [entrez]
PHST- 2011/09/07 06:00 [pubmed]
PHST- 2012/04/20 06:00 [medline]
AID - S0102-76382011000200010 [pii]
AID - 10.1590/s0102-76382011000200010 [doi]
PST - ppublish
SO  - Rev Bras Cir Cardiovasc. 2011 Apr-Jun;26(2):205-12. doi:
      10.1590/s0102-76382011000200010.


PMID- 21893869
OWN - NLM
STAT- MEDLINE
DCOM- 20111213
LR  - 20110906
IS  - 0926-9630 (Print)
IS  - 0926-9630 (Linking)
VI  - 169
DP  - 2011
TI  - De-identifying an EHR database - anonymity, correctness and readability of the
      medical record.
PG  - 862-6
AB  - Electronic health records (EHR) contain a large amount of structured data and
      free text. Exploring and sharing clinical data can improve healthcare and
      facilitate the development of medical software. However, revealing confidential
      information is against ethical principles and laws. We de-identified a Danish EHR
      database with 437,164 patients. The goal was to generate a version with real
      medical records, but related to artificial persons. We developed a
      de-identification algorithm that uses lists of named entities, simple language
      analysis, and special rules. Our algorithm consists of 3 steps: collect lists of 
      identifiers from the database and external resources, define a replacement for
      each identifier, and replace identifiers in structured data and free text. Some
      patient records could not be safely de-identified, so the de-identified database 
      has 323,122 patient records with an acceptable degree of anonymity, readability
      and correctness (F-measure of 95%). The algorithm has to be adjusted for each
      culture, language and database.
FAU - Pantazos, Kostas
AU  - Pantazos K
AD  - Software Development Group, IT-University of Copenhagen, Denmark. kopa@itu.dk
FAU - Lauesen, Soren
AU  - Lauesen S
FAU - Lippert, Soren
AU  - Lippert S
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Stud Health Technol Inform
JT  - Studies in health technology and informatics
JID - 9214582
MH  - Algorithms
MH  - Computer Security
MH  - Confidentiality
MH  - Denmark
MH  - Electronic Health Records
MH  - Humans
MH  - Medical Record Linkage/methods/*standards
MH  - Patient Identification Systems
MH  - Pattern Recognition, Automated
MH  - Primary Health Care/*organization & administration
MH  - Privacy
MH  - Reproducibility of Results
MH  - Security Measures
MH  - Software
EDAT- 2011/09/07 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/09/07 06:00
PHST- 2011/09/07 06:00 [entrez]
PHST- 2011/09/07 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
PST - ppublish
SO  - Stud Health Technol Inform. 2011;169:862-6.


PMID- 21893868
OWN - NLM
STAT- MEDLINE
DCOM- 20111213
LR  - 20110906
IS  - 0926-9630 (Print)
IS  - 0926-9630 (Linking)
VI  - 169
DP  - 2011
TI  - A metadata-based patient register for cooperative clinical research: a case study
      in acute myeloid leukemia.
PG  - 857-61
AB  - In many medical indications clinical research is organized within study groups
      which provide and maintain the clinical infrastructure for their randomized
      clinical trials. Each group also manages a data center where high quality
      databases store the study specific individual patient data. Sharing this data
      between study groups is not straightforward. Therefore, a concept is needed which
      allows to represent a detailed overview on the information available across the
      cooperating groups. We propose a metadata based patient register and describe a
      first prototype. It provides information about available patient data sets to
      interested research partners while the typical register approach only collects a 
      predefined limited core data set. This register implementation enables
      cooperative groups to allocate clinical data for future research projects in
      distributed data sources beyond the restrictions of core data sets. Additionally,
      it supports the research network in communication and data standardization and
      complies with a governance structure which is compatible with ethical aspects,
      privacy protection, and patient rights.
FAU - Fischer, Anja S
AU  - Fischer AS
AD  - Institute for Medical Informatics, Biometry and Epidemiology (IBE),
      Ludwig-Maximilians-University Munich, Germany.
      anja.fischer@ibe.med.uni-muenchen.de
FAU - Mansmann, Ulrich
AU  - Mansmann U
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Stud Health Technol Inform
JT  - Studies in health technology and informatics
JID - 9214582
MH  - Access to Information
MH  - Biomedical Research/trends
MH  - Cooperative Behavior
MH  - Data Collection
MH  - Humans
MH  - Information Dissemination/*methods
MH  - Information Storage and Retrieval/*methods
MH  - Leukemia, Myeloid, Acute/*diagnosis/*epidemiology
MH  - Medical Informatics/*methods
MH  - Randomized Controlled Trials as Topic
MH  - Registries
MH  - Systems Integration
EDAT- 2011/09/07 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/09/07 06:00
PHST- 2011/09/07 06:00 [entrez]
PHST- 2011/09/07 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
PST - ppublish
SO  - Stud Health Technol Inform. 2011;169:857-61.


PMID- 21893829
OWN - NLM
STAT- MEDLINE
DCOM- 20111213
LR  - 20110906
IS  - 0926-9630 (Print)
IS  - 0926-9630 (Linking)
VI  - 169
DP  - 2011
TI  - Improving the transparency of health information found on the internet through
      the honcode: a comparative study.
PG  - 654-8
AB  - This study aims to show that health websites not asking for HONcode certification
      (Control sample websites A) do not respect elementary ethical standards such as
      the HONcode. The HONcode quality and ethical standards and the certification
      process have been developed by the Health on the Net Foundation to improve the
      transparency of the health and medical information found on the Internet. We
      compared the compliance with the 8 HONcode principles, and respectively the
      respect of principles 1 (authority), 4 (assignment), 5 (justification) and 8
      (honesty in advertising and editorial policy) by certified websites (A) and by
      health websites which have not requested the certification (B). The assessment of
      the HONcode compliance was performed by HON evaluators by the same standards for 
      all type of sites. Results shows that 0.6% of health websites not asking for
      HONcode certification does respect the eight HONcode ethical standards vs. 89% of
      certified websites. Regarding the principles 1, 4, 5 and 8, 1.2% of B respect
      these principles vs. 92% for A. The certification process led health websites to 
      respect the ethical and quality standards such as the HONcode, and disclosing the
      production process of the health website.
FAU - Laversin, Sabine
AU  - Laversin S
AD  - Haute Autorite de Sante, France.
FAU - Baujard, Vincent
AU  - Baujard V
FAU - Gaudinat, Arnaud
AU  - Gaudinat A
FAU - Simonet, Maria-Ana
AU  - Simonet MA
FAU - Boyer, Celia
AU  - Boyer C
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Stud Health Technol Inform
JT  - Studies in health technology and informatics
JID - 9214582
MH  - Credentialing
MH  - Ethics, Medical
MH  - Ethics, Professional
MH  - France
MH  - Guidelines as Topic
MH  - Humans
MH  - Internet/*standards
MH  - Medical Informatics/*methods/standards
MH  - Models, Statistical
MH  - Publishing/standards
MH  - Quality Control
MH  - Telemedicine/standards
EDAT- 2011/09/07 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/09/07 06:00
PHST- 2011/09/07 06:00 [entrez]
PHST- 2011/09/07 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
PST - ppublish
SO  - Stud Health Technol Inform. 2011;169:654-8.


PMID- 21893822
OWN - NLM
STAT- MEDLINE
DCOM- 20111213
LR  - 20110906
IS  - 0926-9630 (Print)
IS  - 0926-9630 (Linking)
VI  - 169
DP  - 2011
TI  - Sharing sensitive personal health information through Facebook: the unintended
      consequences.
PG  - 616-20
AB  - The purpose of this paper was to explore the types of sensitive health
      information posted by individuals through social network media sites such as
      Facebook. The researcher found several instances in which individuals, who could 
      be identified by their user profiles, posted personal and sensitive health
      information related to mental and genetic disorders and sexually transmitted
      diseases. The data suggest that Facebook users should be made aware of the
      potential harm that may occur when sharing sensitive health information publicly 
      through Facebook. Ethical considerations in undertaking such research are also
      examined.
FAU - Househ, Mowafa
AU  - Househ M
AD  - College of Public Health and Health Informatics, King Saud Bin Abdulaziz
      University for Health Sciences, National Guard Health Affairs, Riyadh, Saudi
      Arabia. househmo@ngha.med.sa
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Stud Health Technol Inform
JT  - Studies in health technology and informatics
JID - 9214582
MH  - Access to Information
MH  - Anxiety/*diagnosis/physiopathology
MH  - Communication
MH  - Communications Media
MH  - Ethics
MH  - Female
MH  - Health
MH  - Humans
MH  - Male
MH  - *Privacy
MH  - *Self Disclosure
MH  - Social Media
MH  - Social Support
EDAT- 2011/09/07 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/09/07 06:00
PHST- 2011/09/07 06:00 [entrez]
PHST- 2011/09/07 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
PST - ppublish
SO  - Stud Health Technol Inform. 2011;169:616-20.


PMID- 21893799
OWN - NLM
STAT- MEDLINE
DCOM- 20111213
LR  - 20110906
IS  - 0926-9630 (Print)
IS  - 0926-9630 (Linking)
VI  - 169
DP  - 2011
TI  - Framework model and principles for trusted information sharing in pervasive
      health.
PG  - 497-501
AB  - Trustfulness (i.e. health and wellness information is processed ethically, and
      privacy is guaranteed) is one of the cornerstones for future Personal Health
      Systems, ubiquitous healthcare and pervasive health. Trust in today's healthcare 
      is organizational, static and predefined. Pervasive health takes place in an open
      and untrusted information space where person's lifelong health and wellness
      information together with contextual data are dynamically collected and used by
      many stakeholders. This generates new threats that do not exist in today's
      eHealth systems. Our analysis shows that the way security and trust are
      implemented in today's healthcare cannot guarantee information autonomy and
      trustfulness in pervasive health. Based on a framework model of pervasive health 
      and risks analysis of ubiquitous information space, we have formulated principles
      which enable trusted information sharing in pervasive health. Principles imply
      that the data subject should have the right to dynamically verify trust and to
      control the use of her health information, as well as the right to set situation 
      based context-aware personal policies. Data collectors and processors have
      responsibilities including transparency of information processing, and openness
      of interests, policies and environmental features. Our principles create a base
      for successful management of privacy and information autonomy in pervasive
      health. They also imply that it is necessary to create new data models for
      personal health information and new architectures which support situation
      depending trust and privacy management.
FAU - Ruotsalainen, Pekka
AU  - Ruotsalainen P
AD  - National Institute for Health and Welfare, Finland. pekka.ruotsalainen@thl.fi
FAU - Blobel, Bernd
AU  - Blobel B
FAU - Nykanen, Pirkko
AU  - Nykanen P
FAU - Seppala, Antto
AU  - Seppala A
FAU - Sorvari, Hannu
AU  - Sorvari H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Stud Health Technol Inform
JT  - Studies in health technology and informatics
JID - 9214582
MH  - Access to Information
MH  - Computer Communication Networks/*standards
MH  - Computer Security
MH  - Computer Systems
MH  - Confidentiality
MH  - *Health Records, Personal
MH  - Humans
MH  - Information Services/*standards
MH  - Information Systems/standards
MH  - Medical Informatics/*methods
MH  - Medical Records Systems, Computerized/*standards
MH  - Models, Organizational
MH  - Privacy
MH  - Reproducibility of Results
EDAT- 2011/09/07 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/09/07 06:00
PHST- 2011/09/07 06:00 [entrez]
PHST- 2011/09/07 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
PST - ppublish
SO  - Stud Health Technol Inform. 2011;169:497-501.


PMID- 21893758
OWN - NLM
STAT- MEDLINE
DCOM- 20111213
LR  - 20181201
IS  - 0926-9630 (Print)
IS  - 0926-9630 (Linking)
VI  - 169
DP  - 2011
TI  - Everyday ethical dilemmas arising with electronic record use in primary care.
PG  - 285-9
AB  - The introduction of electronic medical record systems (EMRs) into primary care
      settings alters work practices, introduces new challenges, and new roles. In the 
      process of integrating an EMR into a primary care setting, clinic staff faced
      ethical challenges in their everyday work practices resulting from workarounds
      undertaken to compensate for a poor fit between system design and work practices,
      issues related to system access, and governance gaps. Examples of these issues
      are presented, and implications for system design are discussed.
FAU - Balka, Ellen
AU  - Balka E
AD  - Simon Fraser University, Burnaby BC, Canada. ellenb@sfu.ca
FAU - Tolar, Marianne
AU  - Tolar M
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Stud Health Technol Inform
JT  - Studies in health technology and informatics
JID - 9214582
MH  - *Access to Information
MH  - Community Health Services/organization & administration
MH  - Data Collection
MH  - Electronic Health Records/*ethics
MH  - *Ethics, Medical
MH  - Humans
MH  - Medical Informatics/methods
MH  - Medical Records Systems, Computerized/*ethics/statistics & numerical data
MH  - Primary Health Care/statistics & numerical data
EDAT- 2011/09/07 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/09/07 06:00
PHST- 2011/09/07 06:00 [entrez]
PHST- 2011/09/07 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
PST - ppublish
SO  - Stud Health Technol Inform. 2011;169:285-9.


PMID- 21893717
OWN - NLM
STAT- MEDLINE
DCOM- 20111213
LR  - 20110906
IS  - 0926-9630 (Print)
IS  - 0926-9630 (Linking)
VI  - 169
DP  - 2011
TI  - Results of the 10 HON survey on health and medical internet use.
PG  - 73-7
AB  - The Internet is increasingly being used as a means to search and communicate
      health information. As the mission of Health on the Net Foundation (HON) is to
      guide healthcare consumers and professionals to trustworthy online information,
      we have been interested in seeing the trend of the attitudes towards Internet use
      for health purposes since 1996. This article presents the results of the
      10<sup>th</sup> HON survey conducted in July-August 2010 (in English and French).
      It was hosted on the HON site with links from Facebook and Twitter and from
      HONcode certified web sites. There were 524 participants coming mainly from
      France (28%), the UK (18%) and the USA (18%). 65% of participants represented the
      "general public", while the remaining 35% were professionals. Information quality
      remains the main barrier users encounter while looking for health information
      online; at the same time, 79% believe they critically assess online content. Both
      patients and physicians consider the Internet to be helpful in facilitating their
      communication during consultations, although professionals are more sceptic than 
      the general public. These results justify the continuing efforts of HON to raise 
      public awareness regarding online health information and the ethical, quality and
      transparency issues, and to educate and guide users towards trustworthy health
      information.
FAU - Pletneva, Natalia
AU  - Pletneva N
AD  - Health on the Net Foundation, Geneva, Switzerland.
FAU - Cruchet, Sarah
AU  - Cruchet S
FAU - Simonet, Maria-Ana
AU  - Simonet MA
FAU - Kajiwara, Maki
AU  - Kajiwara M
FAU - Boyer, Celia
AU  - Boyer C
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Stud Health Technol Inform
JT  - Studies in health technology and informatics
JID - 9214582
MH  - Access to Information
MH  - Certification
MH  - Health
MH  - Health Education/*methods
MH  - Humans
MH  - Internet
MH  - Language
MH  - Medical Informatics/*instrumentation/methods
MH  - Medical Informatics Applications
MH  - Patient Education as Topic
MH  - Reproducibility of Results
MH  - Switzerland
MH  - United States
EDAT- 2011/09/07 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/09/07 06:00
PHST- 2011/09/07 06:00 [entrez]
PHST- 2011/09/07 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
PST - ppublish
SO  - Stud Health Technol Inform. 2011;169:73-7.


PMID- 21893579
OWN - NLM
STAT- MEDLINE
DCOM- 20111212
LR  - 20110906
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 5
DP  - 2011 Sep
TI  - Comparison of nurse educators' and nursing students' descriptions of teaching
      codes of ethics.
PG  - 710-24
LID - 10.1177/0969733011408054 [doi]
AB  - This study analysed teaching of nurses' codes of ethics in basic nursing
      education in Finland. A total of 183 educators and 214 students responded to a
      structured questionnaire. The data was analysed by SPSS. Teaching of nurses'
      codes was rather extensive. The nurse-patient relationship was highlighted.
      Educators assessed their teaching statistically significantly more extensive than
      what students' perceptions were. The use of teaching and evaluation methods was
      conventional, but differences between the groups concerning the use of these
      methods were statistically significant. Students' knowledge of and their ability 
      to apply the codes was mediocre. Most educators and students assessed educators' 
      knowledge of the codes as adequate for teaching. These educators also taught the 
      codes more extensively and these students perceived the teaching as more
      extensive. Otherwise educators' and students' socio-demographic variables had
      little association with the teaching. Research should focus on the organization
      and effectiveness of ethics education, and on educators' competence.
FAU - Numminen, Olivia
AU  - Numminen O
AD  - Department of Nursing Science, University of Turku, Luotsikatu 9 D 11, 00160
      Helsinki, Finland. j.o.numminen@welho.com
FAU - Leino-Kilpi, Helena
AU  - Leino-Kilpi H
FAU - van der Arend, Arie
AU  - van der Arend A
FAU - Katajisto, Jouko
AU  - Katajisto J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - *Codes of Ethics
MH  - Cross-Sectional Studies
MH  - Ethics, Nursing/*education
MH  - *Faculty, Nursing/statistics & numerical data
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nursing Education Research
MH  - Students, Nursing/*psychology/statistics & numerical data
MH  - Young Adult
EDAT- 2011/09/07 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/09/07 06:00
PHST- 2011/09/07 06:00 [entrez]
PHST- 2011/09/07 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 18/5/710 [pii]
AID - 10.1177/0969733011408054 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Sep;18(5):710-24. doi: 10.1177/0969733011408054.


PMID- 21893576
OWN - NLM
STAT- MEDLINE
DCOM- 20111212
LR  - 20110906
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 5
DP  - 2011 Sep
TI  - Ethical aspects of researching subjective experiences in early-stage dementia.
PG  - 651-61
LID - 10.1177/0969733011408046 [doi]
AB  - This article is based on a qualitative longitudinal study that followed the
      subjective experiences of both people living with dementia and their family
      members during the early stages of the illness. The purpose of this article is to
      describe and reflect on the ethical and methodological issues that occurred
      during data collection. The article focuses on the situation of the person with
      dementia and the family member and the role of the researcher when conducting the
      research interviews. Based on the results of this study, conducting research
      interviews with people with dementia and their family members poses several
      ethical and methodological challenges that must be addressed. In doing so,
      ethically sound dementia-specific research methods will be actively developed
      enhancing our understanding of living with dementia and providing new insights
      into the care of people with dementia and their family members.
FAU - Pesonen, Hanna-Mari
AU  - Pesonen HM
AD  - University of Oulu, Finland. hanna-mari.pesonen@oulu.fi
FAU - Remes, Anne M
AU  - Remes AM
FAU - Isola, Arja
AU  - Isola A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Aged
MH  - Data Collection/*ethics/methods
MH  - Dementia/*psychology
MH  - Family
MH  - Female
MH  - Humans
MH  - *Interview, Psychological/methods
MH  - *Life Change Events
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - *Qualitative Research
MH  - Researcher-Subject Relations
EDAT- 2011/09/07 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/09/07 06:00
PHST- 2011/09/07 06:00 [entrez]
PHST- 2011/09/07 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 18/5/651 [pii]
AID - 10.1177/0969733011408046 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Sep;18(5):651-61. doi: 10.1177/0969733011408046.


PMID- 21893574
OWN - NLM
STAT- MEDLINE
DCOM- 20111212
LR  - 20110906
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 5
DP  - 2011 Sep
TI  - Tools and techniques to solve ethical problems.
PG  - 626-8
LID - 10.1177/0969733011414847 [doi]
FAU - Olsen, Douglas P
AU  - Olsen DP
LA  - eng
PT  - Editorial
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - *Ethics, Nursing
MH  - Humans
MH  - Informed Consent/ethics
MH  - Nurse-Patient Relations/ethics
MH  - Nursing Care/*methods
MH  - *Problem Solving
EDAT- 2011/09/07 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/09/07 06:00
PHST- 2011/09/07 06:00 [entrez]
PHST- 2011/09/07 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 18/5/626 [pii]
AID - 10.1177/0969733011414847 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Sep;18(5):626-8. doi: 10.1177/0969733011414847.


PMID- 21892562
OWN - NLM
STAT- MEDLINE
DCOM- 20120106
LR  - 20191210
IS  - 1699-5198 (Electronic)
IS  - 0212-1611 (Linking)
VI  - 26
IP  - 3
DP  - 2011 May-Jun
TI  - Comparison of NCHS, CDC and WHO growth charts in the nutritional assessment of
      hospitalized children up to five years old.
PG  - 465-71
LID - 10.1590/S0212-16112011000300006 [doi]
LID - S0212-16112011000300006 [pii]
AB  - AIMS: This study evaluated the agreement of growth charts proposed by the
      National Center for Health Statistics (NCHS/1977), Centers for Disease Control
      and Prevention (CDC/2000) and World Health Organization (WHO/2006). METHODS: Were
      assessed children between 0 and 5 years old, hospitalized in the pediatric wards 
      of a Brazilian school hospital. Z-score indexes: stature/age (S/A), weight/age
      (W/A) and weight/stature (W/S) was evaluated, in each of the three references
      (NCHS, CDC and WHO). ANOVA and test Bland & Altman and Lin plots were used in the
      comparison of the 3 charts. The agreement of the nutritional state categories was
      also evaluated, through kappa coefficient. The study was approved by the
      Institution's Research Ethics Committee. RESULTS: The study analyzed 337
      children, whose median age was 0.52 (IQR: 0.21-1.65) years, 65.3% of them were
      below 1 year old, 60.2% were male and 50% hospitalized due to acute respiratory
      disease. Lower Z-scores of W/A and S/A were obtained with the WHO charts and
      lower W/S with the CDC chart. High correlation and agreement were observed among 
      the criteria, but more patients were classified as presenting shortness through
      the WHO criteria. CDC and WHO criteria were more rigorous than the NCHS criteria 
      for the diagnosis of underweight (W/A) and malnutrition (W/S). CONCLUSION:
      Despite the strong agreement of the 3 charts, the adoption of the WHO charts
      seems to be more helpful for the children's nutritional screening for admission, 
      as it enables to detect a higher number of malnourished children or at
      nutritional risk, who will benefit from an early intervention.
FAU - Silveira, C R M
AU  - Silveira CR
AD  - Hospital de Clinicas de Porto Alegre, Rio Grande do Sul, Brasil.
FAU - Beghetto, M G
AU  - Beghetto MG
FAU - Carvalho, P R A
AU  - Carvalho PR
FAU - Mello, E D
AU  - Mello ED
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Spain
TA  - Nutr Hosp
JT  - Nutricion hospitalaria
JID - 9100365
SB  - IM
MH  - Analysis of Variance
MH  - Body Height/physiology
MH  - Body Weight/physiology
MH  - Brazil
MH  - Centers for Disease Control and Prevention, U.S.
MH  - Child, Preschool
MH  - Female
MH  - *Growth Charts
MH  - Hospitalization
MH  - Humans
MH  - Infant
MH  - Male
MH  - National Center for Health Statistics, U.S.
MH  - Nutritional Status
MH  - Reference Standards
MH  - United States
MH  - World Health Organization
EDAT- 2011/09/06 06:00
MHDA- 2012/01/10 06:00
CRDT- 2011/09/06 06:00
PHST- 2009/10/22 00:00 [received]
PHST- 2010/03/15 00:00 [accepted]
PHST- 2011/09/06 06:00 [entrez]
PHST- 2011/09/06 06:00 [pubmed]
PHST- 2012/01/10 06:00 [medline]
AID - S0212-16112011000300006 [pii]
AID - 10.1590/S0212-16112011000300006 [doi]
PST - ppublish
SO  - Nutr Hosp. 2011 May-Jun;26(3):465-71. doi: 10.1590/S0212-16112011000300006.


PMID- 21892358
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 1741-0541 (Print)
IS  - 1741-0541 (Linking)
VI  - 8
IP  - 4
DP  - 2011 Jul
TI  - Comparing different scientific approaches to personalized medicine: research
      ethics and privacy protection.
PG  - 437-444
AB  - In this article, two different scientific approaches to personalized medicine are
      compared. Biorepository at Vanderbilt University (BioVU) is a genomic
      biorepository at Vanderbilt University Medical Center in Nashville, TN, USA.
      Genetic biosamples are collected from leftover clinical blood samples; medical
      information is derived from an electronic medical records. Greifswald Approach to
      Individualized Medicine is a research resource at the University of Greifswald,
      Germany, comprised of clinical records combined with biosamples collected for
      research. We demonstrate that although both approaches are based on the
      collection of clinical data and biosamples, different legal milieus present in
      the USA and Germany as well as slight differences in scientific goals have led to
      different 'ethical designs'. While BioVU can successfully operate with an
      'opt-out' mechanism, an informed consent-based 'opt-in' model is indispensable to
      allow GANI_MED to reach its scientific goals.
FAU - Langanke, Martin
AU  - Langanke M
AD  - Faculty of Theology, University of Greifswald, Greifswald, Germany.
FAU - Brothers, Kyle B
AU  - Brothers KB
FAU - Erdmann, Pia
AU  - Erdmann P
FAU - Weinert, Jakob
AU  - Weinert J
FAU - Krafczyk-Korth, Janina
AU  - Krafczyk-Korth J
FAU - Dorr, Marcus
AU  - Dorr M
FAU - Hoffmann, Wolfgang
AU  - Hoffmann W
FAU - Kroemer, Heyo K
AU  - Kroemer HK
FAU - Assel, Heinrich
AU  - Assel H
LA  - eng
GR  - UL1 RR024975-01/RR/NCRR NIH HHS/United States
GR  - KL2 RR024977/RR/NCRR NIH HHS/United States
GR  - UL1 RR024975/RR/NCRR NIH HHS/United States
GR  - U01 HG004603/HG/NHGRI NIH HHS/United States
GR  - TL1 RR024978/RR/NCRR NIH HHS/United States
GR  - U01 HG004603-03/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PL  - England
TA  - Per Med
JT  - Personalized medicine
JID - 101238549
PMC - PMC3164515
MID - NIHMS316971
EDAT- 2011/09/06 06:00
MHDA- 2011/09/06 06:01
CRDT- 2011/09/06 06:00
PHST- 2011/09/06 06:00 [entrez]
PHST- 2011/09/06 06:00 [pubmed]
PHST- 2011/09/06 06:01 [medline]
AID - 10.2217/pme.11.34 [doi]
PST - ppublish
SO  - Per Med. 2011 Jul;8(4):437-444. doi: 10.2217/pme.11.34.


PMID- 21892337
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1179-1411 (Electronic)
IS  - 1179-1411 (Linking)
VI  - 3
DP  - 2011
TI  - A review of management of infertility in Nigeria: framing the ethics of a
      national health policy.
PG  - 265-75
LID - 10.2147/IJWH.S20501 [doi]
AB  - Infertility has recently been construed to be a serious problem in sub-Saharan
      Africa. This problem seems to be viewed as of low priority with reference to the 
      effective and efficient allocation of available health resources by national
      governments as well as by international donors sponsoring either research or
      service delivery in the public health sector. In this paper the problem of
      infertility in Nigeria is surveyed with a view to assessing the ethical dimension
      of proposals to manage infertility as a public sector priority in health care
      delivery. The population/individual and public/private distinction in the
      formulation of health policy has ethical implications that cannot simply be
      ignored and are therefore engaged in critically assessing the problem of
      infertility. Cost-utility analysis (such as Quality Adjusted Life-Year composite 
      index) in the management of infertility in Nigeria entails the need for caution
      relevant to the country's efforts to achieve Millennium Development Goals. This
      should remain the case whether the ethical evaluation appeals to utilitarian or
      contractarian (Rawlsian) principles. The "worst off " category of Nigerians
      includes (1) underweight children less than 5 years of age, with special concern 
      for infants (0-1 years of age) and (2) the proportion of the population below a
      minimum level of dietary consumption. The Rawlsian ethic implies that any Federal
      Ministry of Health policy aimed at establishing public programs for infertility
      management can be considered a "fair" allocation and expenditure if, and only if,
      the situation for these two cohorts is not thereby made worse. Nigerian health
      policy cannot assume this type of increased allocation of its resources to
      infertility care without it being hard pressed to warrant defensible moral or
      rational argument.
FAU - Akinloye, Oluyemi
AU  - Akinloye O
AD  - Department of Chemical Pathology, Reproductive and Molecular Endocrinology Unit, 
      College of Health Sciences, Ladoke Akintola University of Technology, Osogbo,
      Osun State, Nigeria;
FAU - Truter, Ernest J
AU  - Truter EJ
LA  - eng
PT  - Journal Article
DEP - 20110811
PL  - New Zealand
TA  - Int J Womens Health
JT  - International journal of women's health
JID - 101531698
PMC - PMC3163656
OTO - NOTNLM
OT  - Nigeria
OT  - bioethics
OT  - health policy
OT  - infertility
EDAT- 2011/09/06 06:00
MHDA- 2011/09/06 06:01
CRDT- 2011/09/06 06:00
PHST- 2011/08/10 00:00 [received]
PHST- 2011/09/06 06:00 [entrez]
PHST- 2011/09/06 06:00 [pubmed]
PHST- 2011/09/06 06:01 [medline]
AID - 10.2147/IJWH.S20501 [doi]
AID - ijwh-3-265 [pii]
PST - ppublish
SO  - Int J Womens Health. 2011;3:265-75. doi: 10.2147/IJWH.S20501. Epub 2011 Aug 11.


PMID- 21892220
OWN - NLM
STAT- MEDLINE
DCOM- 20110928
LR  - 20151119
IS  - 1827-6806 (Print)
IS  - 1827-6806 (Linking)
VI  - 12
IP  - 9
DP  - 2011 Sep
TI  - [Praise for a conscious ethical choice].
PG  - 596-8
LID - 10.1714/926.10173 [doi]
FAU - Bovenzi, Francesco Maria
AU  - Bovenzi FM
AD  - U.O. di Cardiologia, Dipartimento Cardio-Respiratorio, Ospedale campo di Marte,
      Lucca. f.bovenzi@tin.it
LA  - ita
PT  - Journal Article
TT  - Elogio di una scelta etica responsabile.
PL  - Italy
TA  - G Ital Cardiol (Rome)
JT  - Giornale italiano di cardiologia (2006)
JID - 101263411
SB  - IM
MH  - Bioethical Issues
MH  - Choice Behavior/*ethics
MH  - Decision Making/ethics
MH  - *Ethics, Medical
MH  - *Ethics, Research
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Italy
MH  - *Personhood
MH  - Precision Medicine/*ethics/trends
MH  - Quality of Life
MH  - *Research/trends
EDAT- 2011/09/06 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/09/06 06:00
PHST- 2011/09/06 06:00 [entrez]
PHST- 2011/09/06 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 10.1714/926.10173 [doi]
PST - ppublish
SO  - G Ital Cardiol (Rome). 2011 Sep;12(9):596-8. doi: 10.1714/926.10173.


PMID- 21891933
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20131121
IS  - 0028-3886 (Print)
IS  - 0028-3886 (Linking)
VI  - 59
IP  - 4
DP  - 2011 Jul-Aug
TI  - Induced pluripotent stem cells and promises of neuroregenerative medicine.
PG  - 555-7
LID - 10.4103/0028-3886.84337 [doi]
AB  - First created in 2006 from adult somatic cells by a simple molecular genetic
      trick, induced pluripotent stem cells (iPS) system is the latest platform in stem
      cell research. Induced pluripotent stem cells are produced by nuclear
      reprogramming technology and they resemble embryonic stem cells (ES) in key
      elements; they possess the potentiality to differentiate into any type of cell in
      the body. More importantly, the iPS platform has distinct advantage over ES
      system in the sense that iPS-derived cells are autologous and therefore the
      iPS-derived transplantation does not require immunosuppressive therapy. In
      addition, iPS research obviates the political and ethical quandary associated
      with embryo destruction and ES research. This remarkable discovery of cellular
      plasticity has important medical implications. This brief review summarizes
      currently available stem cell platforms, with emphasis on cellular reprogramming 
      and iPS technology and its application in disease modeling and cell replacement
      therapy in neurodegenerative diseases.
FAU - Verma, Ashok
AU  - Verma A
AD  - University of Miami Miller School of Medicine, Miami, FL, USA.
      averma@med.miami.edu
FAU - Verma, Nipun
AU  - Verma N
LA  - eng
PT  - Journal Article
PT  - Review
PL  - India
TA  - Neurol India
JT  - Neurology India
JID - 0042005
SB  - IM
MH  - Bioengineering
MH  - Cell- and Tissue-Based Therapy/*methods
MH  - Humans
MH  - Neurodegenerative Diseases/*surgery
MH  - Pluripotent Stem Cells/*physiology/*transplantation
EDAT- 2011/09/06 06:00
MHDA- 2011/11/09 06:00
CRDT- 2011/09/06 06:00
PHST- 2011/09/06 06:00 [entrez]
PHST- 2011/09/06 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - ni_2011_59_4_555_84337 [pii]
AID - 10.4103/0028-3886.84337 [doi]
PST - ppublish
SO  - Neurol India. 2011 Jul-Aug;59(4):555-7. doi: 10.4103/0028-3886.84337.


PMID- 21890860
OWN - NLM
STAT- MEDLINE
DCOM- 20120322
LR  - 20111216
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 1
DP  - 2012 Jan
TI  - Towards a specific approach to education in dental ethics: a proposal for
      organising the topics of biomedical ethics for dental education.
PG  - 60-3
LID - 10.1136/medethics-2011-100067 [doi]
AB  - Understanding dental ethics as a field separate from its much better known
      counterpart, medical ethics, is a relatively new, but necessary approach in
      bioethics. This need is particularly felt in dental education and establishing a 
      curriculum specifically for dental ethics is a challenging task. Although certain
      topics such as informed consent and patient rights can be considered to be of
      equal importance in both fields, a number of ethical issues in dental practice
      are only remotely-if at all-relevant for medical practice. Therefore, any sound
      approach to education in dental ethics has to recognise the unique aspects of
      dental practice in order to meet the needs of dental students and prepare them
      for the ethical challenges they may face during their professional practice. With
      this goal in mind, this paper examines the approach of the authors to dental
      ethics education and proposes a system to organise the topics of biomedical
      ethics for dental education. While the authors' perspective is based on their
      experience in Turkey, the proposed system of classification is not a rigid one;
      it is open to interpretation in other contexts with different social, cultural
      and professional expectations. Therefore, the paper also aims to inspire
      discussion on the development of an ideal dental ethics curriculum at an
      international level.
FAU - Gorkey, Sefik
AU  - Gorkey S
AD  - Marmara Universitesi Tip Fakultesi, Haydarpasa Kampusu Deontoloji AD, Tibbiye
      cad. No. 49, Uskudar, Istanbul, Turkey.
FAU - Guven, Tolga
AU  - Guven T
FAU - Sert, Gurkan
AU  - Sert G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110902
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Bioethics/*education
MH  - Curriculum
MH  - Education, Dental/*methods
MH  - Ethics, Dental/*education
MH  - Ethics, Medical
MH  - Humans
MH  - Informed Consent
MH  - Learning/ethics
MH  - Patient Rights
MH  - Students, Dental
MH  - Turkey
EDAT- 2011/09/06 06:00
MHDA- 2012/03/23 06:00
CRDT- 2011/09/06 06:00
PHST- 2011/09/06 06:00 [entrez]
PHST- 2011/09/06 06:00 [pubmed]
PHST- 2012/03/23 06:00 [medline]
AID - medethics-2011-100067 [pii]
AID - 10.1136/medethics-2011-100067 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Jan;38(1):60-3. doi: 10.1136/medethics-2011-100067. Epub 2011 
      Sep 2.


PMID- 21890857
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20220330
IS  - 1930-7837 (Electronic)
IS  - 0022-0337 (Linking)
VI  - 75
IP  - 9
DP  - 2011 Sep
TI  - Teaching local anesthesia in dental schools: opinions about the
      student-to-student administration model.
PG  - 1263-9
AB  - The student-to-student local anesthesia administration model has been an accepted
      part of the formal curriculum in dental schools for teaching this clinical skill.
      However, there is very little published literature that explores the validity of 
      this model or examines students' attitudes toward it. The ethics of this
      educational model and the value of consent also need to be explored. In this
      study, an online survey regarding the student-to-student administration model was
      used to obtain the opinions of students and faculty members at three dental
      schools in one state of the United States. The survey was distributed by the
      Office of Academic Affairs at each school. A total of 152 individuals responded
      to this survey: 123 (80.9 percent) dental students and twenty-nine (19.1 percent)
      faculty members. The respondents consistently identified the perceived strengths 
      of this model, while a number also identified the need for consent and raised
      ethical concerns. These findings highlight the complex nature of the respondents'
      opinions and raise the question of whether modification of this mode of
      instruction may be needed.
FAU - Hossaini, Mehran
AU  - Hossaini M
AD  - Department of Oral and Maxillofacial Surgery, University of California, San
      Francisco, San Francisco, CA 94143-0440, USA. Mehran.hossaini@ucsf.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Dent Educ
JT  - Journal of dental education
JID - 8000150
RN  - 0 (Anesthetics, Local)
SB  - IM
MH  - *Anesthesia, Local
MH  - Anesthesiology/*education
MH  - Anesthetics, Local/administration & dosage
MH  - *Attitude of Health Personnel
MH  - California
MH  - Education, Dental/*methods
MH  - Humans
MH  - Informed Consent
MH  - Injections/methods
MH  - *Models, Educational
MH  - Students, Dental/*psychology
MH  - Surveys and Questionnaires
MH  - Teaching/*methods
EDAT- 2011/09/06 06:00
MHDA- 2011/10/25 06:00
CRDT- 2011/09/06 06:00
PHST- 2011/09/06 06:00 [entrez]
PHST- 2011/09/06 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
AID - 75/9/1263 [pii]
PST - ppublish
SO  - J Dent Educ. 2011 Sep;75(9):1263-9.


PMID- 21890715
OWN - NLM
STAT- MEDLINE
DCOM- 20120622
LR  - 20120206
IS  - 1049-7323 (Print)
IS  - 1049-7323 (Linking)
VI  - 22
IP  - 3
DP  - 2012 Mar
TI  - A working relationship model that reduces homelessness among people with mental
      illness.
PG  - 373-83
LID - 10.1177/1049732311421180 [doi]
AB  - We applied grounded theory methodology to generate a working relationship model
      that influences motivation for stable housing among homeless people with serious 
      mental illness, to understand the role of a working relationship in critical
      service transitions. We focused on practitioners' perspectives and practices in
      Critical Time Intervention (CTI), a community intervention aimed to reduce
      homelessness through providing support during the transition from institutional
      to community living. We found a working relationship that highlighted
      "nonauthoritative" and "humanistic" features. Workers respected client autonomy
      and maintained flexibility in the format of client contact and service
      activities. They used practice strategies including following client leads and
      informal relating approaches to facilitate the development of client trust. The
      trusting relationship enhanced client interest in obtaining housing and the
      commitment to the transformation crucial for retaining housing. We discuss the
      significance of the relationship and ethical considerations of
      relationship-building activities in community mental health practices.
FAU - Chen, Fang-Pei
AU  - Chen FP
AD  - Columbia University, New York, New York 10027, USA. fc2208@columbia.edu
FAU - Ogden, Lydia
AU  - Ogden L
LA  - eng
GR  - P30 MH071430/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110902
PL  - United States
TA  - Qual Health Res
JT  - Qualitative health research
JID - 9202144
MH  - Adaptation, Psychological
MH  - Adult
MH  - Female
MH  - Homeless Persons/*psychology
MH  - Humans
MH  - *Interpersonal Relations
MH  - Interview, Psychological
MH  - Male
MH  - Mental Disorders/*psychology
MH  - Mental Health
MH  - Middle Aged
MH  - Models, Psychological
MH  - Motivation
MH  - Personal Autonomy
MH  - Qualitative Research
MH  - *Social Support
MH  - Stress, Psychological
EDAT- 2011/09/06 06:00
MHDA- 2012/06/23 06:00
CRDT- 2011/09/06 06:00
PHST- 2011/09/06 06:00 [entrez]
PHST- 2011/09/06 06:00 [pubmed]
PHST- 2012/06/23 06:00 [medline]
AID - 1049732311421180 [pii]
AID - 10.1177/1049732311421180 [doi]
PST - ppublish
SO  - Qual Health Res. 2012 Mar;22(3):373-83. doi: 10.1177/1049732311421180. Epub 2011 
      Sep 2.


PMID- 21890450
OWN - NLM
STAT- MEDLINE
DCOM- 20120611
LR  - 20211020
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Linking)
VI  - 120
IP  - 1
DP  - 2012 Jan
TI  - Conducting research with tribal communities: sovereignty, ethics, and
      data-sharing issues.
PG  - 6-10
LID - 10.1289/ehp.1103904 [doi]
AB  - BACKGROUND: When conducting research with American Indian tribes, informed
      consent beyond conventional institutional review board (IRB) review is needed
      because of the potential for adverse consequences at a community or governmental 
      level that are unrecognized by academic researchers. OBJECTIVES: In this article,
      we review sovereignty, research ethics, and data-sharing considerations when
      doing community-based participatory health-related or natural-resource-related
      research with American Indian nations and present a model material and
      data-sharing agreement that meets tribal and university requirements. DISCUSSION:
      Only tribal nations themselves can identify potential adverse outcomes, and they 
      can do this only if they understand the assumptions and methods of the proposed
      research. Tribes must be truly equal partners in study design, data collection,
      interpretation, and publication. Advances in protection of intellectual property 
      rights (IPR) are also applicable to IRB reviews, as are principles of sovereignty
      and indigenous rights, all of which affect data ownership and control.
      CONCLUSIONS: Academic researchers engaged in tribal projects should become
      familiar with all three areas: sovereignty, ethics and informed consent, and IPR.
      We recommend developing an agreement with tribal partners that reflects both
      health-related IRB and natural-resource-related IPR considerations.
FAU - Harding, Anna
AU  - Harding A
AD  - School of Biological and Population Health Sciences, College of Public Health and
      Human Sciences, Oregon State University, Corvallis, OR 97331, USA.
      anna.harding@oregonstate.edu
FAU - Harper, Barbara
AU  - Harper B
FAU - Stone, Dave
AU  - Stone D
FAU - O'Neill, Catherine
AU  - O'Neill C
FAU - Berger, Patricia
AU  - Berger P
FAU - Harris, Stuart
AU  - Harris S
FAU - Donatuto, Jamie
AU  - Donatuto J
LA  - eng
GR  - P42 ES016465/ES/NIEHS NIH HHS/United States
GR  - P42ES016465/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110902
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
SB  - IM
MH  - Ethics Committees, Research
MH  - *Ethics, Research
MH  - Human Rights
MH  - Humans
MH  - *Indians, North American
MH  - Information Dissemination/*ethics
MH  - Intellectual Property
MH  - *Research Design
PMC - PMC3261947
EDAT- 2011/09/06 06:00
MHDA- 2012/06/12 06:00
CRDT- 2011/09/06 06:00
PHST- 2011/05/06 00:00 [received]
PHST- 2011/09/02 00:00 [accepted]
PHST- 2011/09/06 06:00 [entrez]
PHST- 2011/09/06 06:00 [pubmed]
PHST- 2012/06/12 06:00 [medline]
AID - 10.1289/ehp.1103904 [doi]
PST - ppublish
SO  - Environ Health Perspect. 2012 Jan;120(1):6-10. doi: 10.1289/ehp.1103904. Epub
      2011 Sep 2.


PMID- 21890056
OWN - NLM
STAT- MEDLINE
DCOM- 20110921
LR  - 20151119
IS  - 1474-547X (Electronic)
IS  - 0140-6736 (Linking)
VI  - 378
IP  - 9794
DP  - 2011 Sep 3
TI  - Effectiveness of battlefield-ethics training during combat deployment: a
      programme assessment.
PG  - 915-24
LID - 10.1016/S0140-6736(11)61039-8 [doi]
AB  - BACKGROUND: Breakdowns in the ethical conduct of soldiers towards non-combatants 
      on the battlefield are of grave concern in war. Evidence-based training
      approaches to prevent unethical conduct are scarce. We assessed the effectiveness
      of battlefield-ethics training and factors associated with unethical battlefield 
      conduct. METHODS: The training package, based on movie vignettes and leader-led
      discussions, was administered 7 to 8 months into a 15-month high-intensity combat
      deployment in Iraq, between Dec 11, 2007, and Jan 30, 2008. Soldiers from an
      infantry brigade combat team (total population about 3500) were randomly
      selected, on the basis of company and the last four digits of each soldier's
      social security number, and invited to complete an anonymous survey 3 months
      after completion of the training. Reports of unethical behaviour and attitudes in
      this sample were compared with a randomly selected pre-training sample from the
      same brigade. The response patterns for ethical behaviour and reporting of
      ethical violations were analysed with chi-square analyses. We developed two
      logistic regression models using self-reported unethical behaviours as dependent 
      variables. Factors associated with unethical conduct, including combat
      experiences and post-traumatic stress disorder (PTSD), were assessed with
      validated scales. FINDINGS: Of 500 randomly selected soldiers 421 agreed to
      participate in the anonymous post-training survey. A total of 397 soldiers of the
      same brigade completed the pre-training survey. Training was associated with
      significantly lower rates of unethical conduct of soldiers and greater
      willingness to report and address misconduct than in those before training. For
      example, reports of unnecessary damage or destruction of private property
      decreased from 13.6% (54 of 397; 95% CI 10.2-17.0) before training to 5.0% (21 of
      421; 2.9-7.1) after training (percent difference -63.2%; p<0.0001), and
      willingness to report a unit member for mistreatment of a non-combatant increased
      from 36.0% (143 of 397; 31.3-40.7) to 58.9% (248 of 421; 54.2-63.6; percent
      difference 63.6; p<0.0001). Nearly all participants (410 [97%]) reported that
      training made it clear how to respond towards non-combatants. Combat frequency
      and intensity was the strongest predictor of unethical behaviour; PTSD was not a 
      significant predictor of unethical behaviour after controlling for combat
      experiences. INTERPRETATION: Leader-led battlefield ethics training positively
      influenced soldiers' understanding of how to interact with and treat
      non-combatants, and reduced reports of ethical misconduct. Unethical battlefield 
      conduct was associated with high-intensity combat but not with PTSD. FUNDING:
      None.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Warner, Christopher H
AU  - Warner CH
AD  - Command and General Staff College, Fort Leavenworth, KS, USA.
      christopher.h.warner@us.army.mil
FAU - Appenzeller, George N
AU  - Appenzeller GN
FAU - Mobbs, Angela
AU  - Mobbs A
FAU - Parker, Jessica R
AU  - Parker JR
FAU - Warner, Carolynn M
AU  - Warner CM
FAU - Grieger, Thomas
AU  - Grieger T
FAU - Hoge, Charles W
AU  - Hoge CW
LA  - eng
PT  - Journal Article
PL  - England
TA  - Lancet
JT  - Lancet (London, England)
JID - 2985213R
SB  - IM
CIN - Lancet. 2011 Sep 3;378(9794):857-9. PMID: 21890034
MH  - Attitude
MH  - Behavior
MH  - *Codes of Ethics
MH  - Data Collection
MH  - Humans
MH  - *Iraq War, 2003-2011
MH  - Military Personnel/*education
MH  - Military Science/*ethics
MH  - United States
MH  - Warfare/*ethics
EDAT- 2011/09/06 06:00
MHDA- 2011/09/22 06:00
CRDT- 2011/09/06 06:00
PHST- 2011/09/06 06:00 [entrez]
PHST- 2011/09/06 06:00 [pubmed]
PHST- 2011/09/22 06:00 [medline]
AID - S0140-6736(11)61039-8 [pii]
AID - 10.1016/S0140-6736(11)61039-8 [doi]
PST - ppublish
SO  - Lancet. 2011 Sep 3;378(9794):915-24. doi: 10.1016/S0140-6736(11)61039-8.


PMID- 21890020
OWN - NLM
STAT- MEDLINE
DCOM- 20120119
LR  - 20110905
IS  - 1557-9840 (Electronic)
IS  - 0095-5108 (Linking)
VI  - 38
IP  - 3
DP  - 2011 Sep
TI  - Care at the edge of viability: medical and ethical issues.
PG  - 471-92
LID - 10.1016/j.clp.2011.06.004 [doi]
AB  - Decision-making for extremely immature preterm infants at the margins of
      viability is ethically, professionally, and emotionally complicated. A standard
      for prenatal consultation should be developed incorporating assessment of
      parental decision-making preferences and styles, a communication process
      involving a reciprocal exchange of information, and effective strategies for
      decisional deliberation, guided by and consistent with parental moral framework. 
      Professional caregivers providing perinatal consultations or end-of-life
      counseling for extremely preterm infants should be sensitive to these issues and 
      be taught flexibility in counseling techniques adhering to consistent guidelines.
      Emphasis must shift away from physician beliefs and behaviors about the
      boundaries of viability.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Haward, Marlyse F
AU  - Haward MF
AD  - Division of Neonatology, Albert Einstein College of Medicine, Children's Hospital
      at Montefiore, Bronx, NY 10461, USA. mhaward@montefiore.org
FAU - Kirshenbaum, Nancy W
AU  - Kirshenbaum NW
FAU - Campbell, Deborah E
AU  - Campbell DE
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Clin Perinatol
JT  - Clinics in perinatology
JID - 7501306
SB  - IM
MH  - Counseling/*ethics
MH  - Decision Making/*ethics
MH  - Female
MH  - *Fetal Viability
MH  - Humans
MH  - Infant, Newborn
MH  - *Infant, Premature
MH  - Infant, Very Low Birth Weight
MH  - Pregnancy
MH  - Prenatal Care/ethics/*psychology
EDAT- 2011/09/06 06:00
MHDA- 2012/01/20 06:00
CRDT- 2011/09/06 06:00
PHST- 2011/09/06 06:00 [entrez]
PHST- 2011/09/06 06:00 [pubmed]
PHST- 2012/01/20 06:00 [medline]
AID - S0095-5108(11)00055-8 [pii]
AID - 10.1016/j.clp.2011.06.004 [doi]
PST - ppublish
SO  - Clin Perinatol. 2011 Sep;38(3):471-92. doi: 10.1016/j.clp.2011.06.004.


PMID- 21889865
OWN - NLM
STAT- MEDLINE
DCOM- 20120806
LR  - 20211020
IS  - 1873-5134 (Electronic)
IS  - 0738-3991 (Linking)
VI  - 87
IP  - 1
DP  - 2012 Apr
TI  - A conceptual model of the role of communication in surrogate decision making for 
      hospitalized adults.
PG  - 54-61
LID - 10.1016/j.pec.2011.07.027 [doi]
AB  - OBJECTIVE: To build a conceptual model of the role of communication in decision
      making, based on literature from medicine, communication studies and medical
      ethics. METHODS: We proposed a model and described each construct in detail. We
      review what is known about interpersonal and patient-physician communication,
      described literature about surrogate-clinician communication, and discussed
      implications for our developing model. RESULTS: The communication literature
      proposes two major elements of interpersonal communication: information
      processing and relationship building. These elements are composed of constructs
      such as information disclosure and emotional support that are likely to be
      relevant to decision making. We propose these elements of communication impact
      decision making, which in turn affects outcomes for both patients and surrogates.
      Decision making quality may also mediate the relationship between communication
      and outcomes. CONCLUSION: Although many elements of the model have been studied
      in relation to patient-clinician communication, there is limited data about
      surrogate decision making. There is evidence of high surrogate distress
      associated with decision making that may be alleviated by communication-focused
      interventions. More research is needed to test the relationships proposed in the 
      model. PRACTICE IMPLICATIONS: Good communication with surrogates may improve both
      the quality of medical decisions and outcomes for the patient and surrogate.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Torke, Alexia M
AU  - Torke AM
AD  - Indiana University Center for Aging Research, Regenstrief Institute,
      Indianapolis, IN 46202, USA. atorke@iupui.edu
FAU - Petronio, Sandra
AU  - Petronio S
FAU - Sachs, Greg A
AU  - Sachs GA
FAU - Helft, Paul R
AU  - Helft PR
FAU - Purnell, Christianna
AU  - Purnell C
LA  - eng
GR  - K23 AG031323/AG/NIA NIH HHS/United States
GR  - K23 AG031323-01A2/AG/NIA NIH HHS/United States
GR  - K23AG031323/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110901
PL  - Ireland
TA  - Patient Educ Couns
JT  - Patient education and counseling
JID - 8406280
MH  - Adult
MH  - *Communication
MH  - *Decision Making
MH  - Decision Support Techniques
MH  - Female
MH  - *Hospitalization
MH  - Humans
MH  - Interpersonal Relations
MH  - Male
MH  - *Physician-Patient Relations
MH  - *Proxy
MH  - *Third-Party Consent
PMC - PMC3246097
MID - NIHMS322438
EDAT- 2011/09/06 06:00
MHDA- 2012/08/07 06:00
CRDT- 2011/09/06 06:00
PHST- 2011/03/21 00:00 [received]
PHST- 2011/07/13 00:00 [revised]
PHST- 2011/07/31 00:00 [accepted]
PHST- 2011/09/06 06:00 [entrez]
PHST- 2011/09/06 06:00 [pubmed]
PHST- 2012/08/07 06:00 [medline]
AID - S0738-3991(11)00420-4 [pii]
AID - 10.1016/j.pec.2011.07.027 [doi]
PST - ppublish
SO  - Patient Educ Couns. 2012 Apr;87(1):54-61. doi: 10.1016/j.pec.2011.07.027. Epub
      2011 Sep 1.


PMID- 21889706
OWN - NLM
STAT- MEDLINE
DCOM- 20111110
LR  - 20121003
IS  - 1097-6809 (Electronic)
IS  - 0741-5214 (Linking)
VI  - 54
IP  - 3
DP  - 2011 Sep
TI  - Ethics of re-hearsing procedures on a corpse.
PG  - 879-80
LID - 10.1016/j.jvs.2011.07.033 [doi]
AB  - You are the attending surgeon of a homeless pedestrian who sustained multiple
      injuries when struck by a car. He died soon after being brought to the emergency 
      department. It is late in the evening. A first-year resident and a medical
      student have been helping with the failed attempt at resuscitation. The emergency
      department is empty, except for your case. A central line kit lies on the bed,
      opened but not used. The junior resident asks your permission for herself and the
      student to practice the technique of subclavian cauterization and tracheal
      intubation on the fresh cadaver to get a "feel" for the procedures. There is no
      medical simulation for these procedures at your medical center. The best ethical 
      response is: A. Tell them to go ahead and practice. B. They can only practice
      intubation because it leaves no external wounds. C. You should supervise them
      yourself to assure educational benefit. D. They should wait until you get
      permission from the medical examiner. E. The present case is not appropriate for 
      educational purposes.
CI  - Copyright (c) 2011 Society for Vascular Surgery. Published by Mosby, Inc. All
      rights reserved.
FAU - Jones, James W
AU  - Jones JW
AD  - Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston,
      Tex., USA. jwjones@bcm.tmc.edu
FAU - McCullough, Laurence B
AU  - McCullough LB
LA  - eng
PT  - Editorial
PL  - United States
TA  - J Vasc Surg
JT  - Journal of vascular surgery
JID - 8407742
SB  - IM
MH  - Accidents, Traffic/mortality
MH  - Attitude of Health Personnel
MH  - Cadaver
MH  - Cautery/*ethics
MH  - Clinical Competence
MH  - Education, Medical, Graduate/*ethics
MH  - Emergency Medicine/*education/*ethics
MH  - Health Knowledge, Attitudes, Practice
MH  - Homeless Persons
MH  - Humans
MH  - Informed Consent
MH  - Internship and Residency/*ethics
MH  - Intubation, Intratracheal/*ethics
MH  - Subclavian Artery/*surgery
EDAT- 2011/09/06 06:00
MHDA- 2011/11/11 06:00
CRDT- 2011/09/06 06:00
PHST- 2011/09/06 06:00 [entrez]
PHST- 2011/09/06 06:00 [pubmed]
PHST- 2011/11/11 06:00 [medline]
AID - S0741-5214(11)01638-7 [pii]
AID - 10.1016/j.jvs.2011.07.033 [doi]
PST - ppublish
SO  - J Vasc Surg. 2011 Sep;54(3):879-80. doi: 10.1016/j.jvs.2011.07.033.


PMID- 21889294
OWN - NLM
STAT- MEDLINE
DCOM- 20120209
LR  - 20111003
IS  - 1873-6513 (Electronic)
IS  - 0885-3924 (Linking)
VI  - 42
IP  - 4
DP  - 2011 Oct
TI  - No place like the hospital.
PG  - 643-8
LID - 10.1016/j.jpainsymman.2011.07.001 [doi]
AB  - The gold standard for end-of-life care is home hospice. A case is presented in
      which a patient dying of irreversible small bowel obstruction from metastatic
      cancer insisted on remaining in the acute care hospital for care when alternative
      sites of care, including a skilled nursing facility and residential hospice, were
      available to her and covered by her health insurance plan. The ethical issues
      raised by this case are discussed from the perspective of the patient, the
      clinical team, the hospital, and the insurance company. Over the past decade,
      hospital-based palliative care consultation and general inpatient hospice care
      have sought to improve the quality of dying in the hospital. To the extent that
      such efforts have been successful, they may result in increasing demand for the
      hospital as the site for terminal care in the future.
CI  - Copyright (c) 2011 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. 
      All rights reserved.
FAU - Gillick, Muriel R
AU  - Gillick MR
AD  - Harvard Pilgrim Health Care Institute, Boston, Massachusetts 02215, USA.
      mgillick@partners.org
FAU - Sabin, James E
AU  - Sabin JE
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20110901
PL  - United States
TA  - J Pain Symptom Manage
JT  - Journal of pain and symptom management
JID - 8605836
SB  - IM
MH  - Female
MH  - Hospice Care/*ethics
MH  - Hospitalization
MH  - Humans
MH  - Middle Aged
MH  - Ovarian Neoplasms/*therapy
MH  - Terminal Care/*ethics
EDAT- 2011/09/06 06:00
MHDA- 2012/02/10 06:00
CRDT- 2011/09/06 06:00
PHST- 2011/03/22 00:00 [received]
PHST- 2011/07/06 00:00 [revised]
PHST- 2011/07/12 00:00 [accepted]
PHST- 2011/09/06 06:00 [entrez]
PHST- 2011/09/06 06:00 [pubmed]
PHST- 2012/02/10 06:00 [medline]
AID - S0885-3924(11)00380-0 [pii]
AID - 10.1016/j.jpainsymman.2011.07.001 [doi]
PST - ppublish
SO  - J Pain Symptom Manage. 2011 Oct;42(4):643-8. doi:
      10.1016/j.jpainsymman.2011.07.001. Epub 2011 Sep 1.


PMID- 21889278
OWN - NLM
STAT- MEDLINE
DCOM- 20120912
LR  - 20120430
IS  - 1879-1476 (Electronic)
IS  - 0385-8146 (Linking)
VI  - 39
IP  - 4
DP  - 2012 Aug
TI  - Surgical management of tongue cancer during pregnancy.
PG  - 428-30
LID - 10.1016/j.anl.2011.08.003 [doi]
AB  - There are ethical dilemmas in managing head and neck cancers during pregnancy.
      Diagnostic and treatment modalities need to be carefully determined. We herein
      describe 3 cases of tongue cancer during pregnancy. The details of the management
      would contribute to the daily practices for head and neck cancers. All three
      patients were Japanese female patients, two of them were 29 years old and one was
      26 years old. All patients were admitted to the Nippon Medical School Hospital
      during pregnancy, complaining of oral pain and/or discomfort. Case 1 was
      diagnosed as tongue cancer stage T3N0M0, however, the tumor was superficial and
      controllable by partial glossectomy. Case 2 was stage T2N0M0 with deep invasion
      with ulcer, and the hemi-glossectomy with neck dissection and the reconstruction 
      was thought to be the standard modality. However, she underwent partial
      glossectomy in order to reduce the stress of the fetus. Case 3 could not be
      diagnosed on admission by biopsy and she underwent partial glossectomy after
      delivery. In case 3, the pathological diagnosis was pT1 tongue cancer. In case 1 
      and case 3, the patient and baby were healthy. In case 2, however, the patient
      died of recurrence at the primary site. In decision making of the strategy, the
      most important factors are not only oncological evaluation but also ethical and
      emotional factors.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Yokoshima, Kazuhiko
AU  - Yokoshima K
AD  - Department of Otolaryngology, Head and Neck Surgery, Nippon Medical School,
      1-1-5, Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan. kyok@nms.ac.jp
FAU - Nakamizo, Munenaga
AU  - Nakamizo M
FAU - Sakanushi, Atsuko
AU  - Sakanushi A
FAU - Ozu, Ryu-ichiro
AU  - Ozu R
FAU - Yamaguchi, Satoshi
AU  - Yamaguchi S
FAU - Tone, Yuko
AU  - Tone Y
FAU - Inai, Shunta
AU  - Inai S
FAU - Murakami, Ryousuke
AU  - Murakami R
FAU - Okubo, Kimihiro
AU  - Okubo K
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20110901
PL  - Netherlands
TA  - Auris Nasus Larynx
JT  - Auris, nasus, larynx
JID - 7708170
SB  - IM
MH  - Adult
MH  - Carcinoma, Squamous Cell/*surgery
MH  - *Ethics, Medical
MH  - Female
MH  - Glossectomy
MH  - Humans
MH  - Lymphatic Metastasis
MH  - Neck Dissection
MH  - Pregnancy
MH  - Pregnancy Complications, Neoplastic/*psychology/*surgery
MH  - Tongue Neoplasms/*surgery
EDAT- 2011/09/06 06:00
MHDA- 2012/09/13 06:00
CRDT- 2011/09/06 06:00
PHST- 2011/04/11 00:00 [received]
PHST- 2011/07/30 00:00 [revised]
PHST- 2011/08/01 00:00 [accepted]
PHST- 2011/09/06 06:00 [entrez]
PHST- 2011/09/06 06:00 [pubmed]
PHST- 2012/09/13 06:00 [medline]
AID - S0385-8146(11)00212-4 [pii]
AID - 10.1016/j.anl.2011.08.003 [doi]
PST - ppublish
SO  - Auris Nasus Larynx. 2012 Aug;39(4):428-30. doi: 10.1016/j.anl.2011.08.003. Epub
      2011 Sep 1.


PMID- 21888695
OWN - NLM
STAT- MEDLINE
DCOM- 20120127
LR  - 20220317
IS  - 1677-6119 (Electronic)
IS  - 1677-5538 (Linking)
VI  - 37
IP  - 4
DP  - 2011 Jul-Aug
TI  - Cell phones and male infertility: a review of recent innovations in technology
      and consequences.
PG  - 432-54
AB  - Cell phones have become a vital part of everyday life. However, the health risks 
      associated with their usage are often overlooked. Recently, evidence from several
      studies supports a growing claim that cell phone usage may have a detrimental
      effect on sperm parameters leading to decreased male fertility. Nonetheless,
      other studies showed no conclusive link between male infertility and cell phone
      usage. The ambiguity of such results is attributed to the lack of a centralized
      assay for measuring inflicted damage caused by cell phones. Study design, ethics,
      and reproducibility are all aspects which must be standardized before any
      conclusions can be made.
FAU - Agarwal, Ashok
AU  - Agarwal A
AD  - Center for Reproductive Medicine, Cleveland Clinic, Cleveland, Ohio, USA.
FAU - Singh, Aspinder
AU  - Singh A
FAU - Hamada, Alaa
AU  - Hamada A
FAU - Kesari, Kavindra
AU  - Kesari K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Brazil
TA  - Int Braz J Urol
JT  - International braz j urol : official journal of the Brazilian Society of Urology
JID - 101158091
SB  - IM
MH  - Cell Phone/*instrumentation
MH  - Humans
MH  - Infertility, Male/*etiology
MH  - Male
MH  - Semen/*radiation effects
MH  - Testis/*radiation effects
EDAT- 2011/09/06 06:00
MHDA- 2012/01/28 06:00
CRDT- 2011/09/06 06:00
PHST- 2011/03/25 00:00 [accepted]
PHST- 2011/09/06 06:00 [entrez]
PHST- 2011/09/06 06:00 [pubmed]
PHST- 2012/01/28 06:00 [medline]
AID - IBJUv37n4a1 [pii]
AID - 10.1590/s1677-55382011000400002 [doi]
PST - ppublish
SO  - Int Braz J Urol. 2011 Jul-Aug;37(4):432-54. doi: 10.1590/s1677-55382011000400002.


PMID- 21888511
OWN - NLM
STAT- MEDLINE
DCOM- 20120515
LR  - 20120117
IS  - 1545-326X (Electronic)
IS  - 0066-4219 (Linking)
VI  - 63
DP  - 2012
TI  - Direct-to-consumer genetic testing: perceptions, problems, and policy responses.
PG  - 23-33
LID - 10.1146/annurev-med-062110-123753 [doi]
AB  - Direct-to-consumer (DTC) genetic testing has attracted a great amount of
      attention from policy makers, the scientific community, professional groups, and 
      the media. Although it is unclear what the public demand is for these services,
      there does appear to be public interest in personal genetic risk information. As 
      a result, many commentators have raised a variety of social, ethical, and
      regulatory issues associated with this emerging industry, including privacy
      issues, ensuring that DTC companies provide accurate information about the risks 
      and limitations of their services, the possible adverse impact of DTC genetic
      testing on healthcare systems, and concern about how individuals may interpret
      and react to genetic risk information.
FAU - Caulfield, Timothy
AU  - Caulfield T
AD  - Faculty of Law and School of Public Health, Health Law and Science Policy Group, 
      University of Alberta, Edmonton AB T6G 2H5, Alberta, Canada.
      tcaulfld@law.ualberta.ca
FAU - McGuire, Amy L
AU  - McGuire AL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110901
PL  - United States
TA  - Annu Rev Med
JT  - Annual review of medicine
JID - 2985151R
SB  - IM
MH  - *Genetic Diseases, Inborn/diagnosis/epidemiology/genetics
MH  - Genetic Predisposition to Disease/epidemiology/genetics
MH  - Genetic Privacy/*trends
MH  - Genetic Testing/economics/*trends
MH  - Health Policy/*trends
MH  - Humans
MH  - Marketing of Health Services/economics/*trends
MH  - Risk Factors
EDAT- 2011/09/06 06:00
MHDA- 2012/05/16 06:00
CRDT- 2011/09/06 06:00
PHST- 2011/09/06 06:00 [entrez]
PHST- 2011/09/06 06:00 [pubmed]
PHST- 2012/05/16 06:00 [medline]
AID - 10.1146/annurev-med-062110-123753 [doi]
PST - ppublish
SO  - Annu Rev Med. 2012;63:23-33. doi: 10.1146/annurev-med-062110-123753. Epub 2011
      Sep 1.


PMID- 21888497
OWN - NLM
STAT- MEDLINE
DCOM- 20120202
LR  - 20110928
IS  - 1476-4954 (Electronic)
IS  - 1476-4954 (Linking)
VI  - 24 Suppl 1
DP  - 2011 Oct
TI  - Reconciling ethical and legal aspects in neonatal intensive care.
PG  - 126-8
LID - 10.3109/14767058.2011.607672 [doi]
AB  - During the last two decades there has been an enormous development in treatment
      possibilities for the extremely premature infants and the Neonatologists have to 
      face in their daily practice many decisional problems and ethical, moral and
      legal dilemmas. These concern decisions to initiate or withhold treatment
      directly at birth, decision to withdrawn treatment with the possible consequence 
      that the child will die. The debate between "sanctity" and "quality" of life,
      aggressive treatment in relation to discrimination toward the disabled, the
      principle of "beneficence" and the question of "proportionality" of treatment,
      the concept of the newborn's "best interest" are the ethical issues discussed.
      According to our opinion, ethical questions should not be regulated by law and
      the legal system should not interfere in the relationship patient - physician.
      Today more than ever, every neonatologist needs to become familiar with basic
      ethical concepts and the legal aspects in neonatal intensive care.
FAU - Messner, Hubert
AU  - Messner H
AD  - NICU, Hospital of Bolzano, Italy. hubert.messner@asbz.it
FAU - Gentili, Lino
AU  - Gentili L
LA  - eng
PT  - Journal Article
DEP - 20110902
PL  - England
TA  - J Matern Fetal Neonatal Med
JT  - The journal of maternal-fetal & neonatal medicine : the official journal of the
      European Association of Perinatal Medicine, the Federation of Asia and Oceania
      Perinatal Societies, the International Society of Perinatal Obstetricians
JID - 101136916
SB  - IM
MH  - Decision Making/physiology
MH  - Humans
MH  - Infant, Extremely Low Birth Weight/physiology
MH  - Infant, Newborn
MH  - Infant, Premature/physiology
MH  - Intensive Care Units, Neonatal/ethics/legislation & jurisprudence
MH  - Intensive Care, Neonatal/*ethics/*legislation & jurisprudence
MH  - Moral Obligations
MH  - Neonatology/ethics/legislation & jurisprudence/methods
MH  - Physician-Patient Relations
MH  - Withholding Treatment
EDAT- 2011/09/06 06:00
MHDA- 2012/02/03 06:00
CRDT- 2011/09/06 06:00
PHST- 2011/09/06 06:00 [entrez]
PHST- 2011/09/06 06:00 [pubmed]
PHST- 2012/02/03 06:00 [medline]
AID - 10.3109/14767058.2011.607672 [doi]
PST - ppublish
SO  - J Matern Fetal Neonatal Med. 2011 Oct;24 Suppl 1:126-8. doi:
      10.3109/14767058.2011.607672. Epub 2011 Sep 2.


PMID- 21888215
OWN - NLM
STAT- MEDLINE
DCOM- 20111027
LR  - 20191112
IS  - 0102-6933 (Print)
IS  - 0102-6933 (Linking)
VI  - 32
IP  - 1
DP  - 2011 Mar
TI  - [Pressure ulcers in the elderly: analysis of prevalence and risk factors].
PG  - 143-50
AB  - Studies on the prevalence of pressure ulcer and e.rperiences of living with
      elderly people with injuries during practice in long-stay institutions for the
      elderly have given rise to many concerns. This work aims to examine the
      prevalence and risk factors of pressure ulcer in the institutionalized elderly.
      This retrospective, quantitative study was held in a public long-stay institution
      for the elderly in Fortaleza, Ceara, Brazil. The sample consisted of 300 medical 
      records of elderly from 2006 to 9009. It was used for data collection form. All
      ethical guidelines were followed. The most prevalent risk factors were: stroke
      (60%) and hypertension (74.3%). The average prevalence of pressure ulcers in the 
      period was 18.8%, rangingfrom 11.1% to 23.2%. The recommendations for the
      prevention of pressure ulcers include the development of a prevention program to 
      promote active aging
FAU - de Freitas, Maria Celia
AU  - de Freitas MC
AD  - Universidade Estadual do Ceara, Fortaleza, Ceara, Brasil.
      maria.celia30@terra.com.br
FAU - Medeiros, Adriana Bessa Fernandes
AU  - Medeiros AB
FAU - Guedes, Maria Vilani Cavalcante
AU  - Guedes MV
FAU - de Almeida, Paulo Cesar
AU  - de Almeida PC
FAU - de Galiza, Francisca Tereza
AU  - de Galiza FT
FAU - Nogueira, Jessica de Menezes
AU  - Nogueira Jde M
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Ulcera por pressao em idosos institucionalizados: analise da prevalencia e
      fatores de risco.
PL  - Brazil
TA  - Rev Gaucha Enferm
JT  - Revista gaucha de enfermagem
JID - 8504882
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pressure Ulcer/*epidemiology
MH  - Prevalence
MH  - Retrospective Studies
MH  - Risk Factors
EDAT- 2011/09/06 06:00
MHDA- 2011/10/28 06:00
CRDT- 2011/09/06 06:00
PHST- 2011/09/06 06:00 [entrez]
PHST- 2011/09/06 06:00 [pubmed]
PHST- 2011/10/28 06:00 [medline]
AID - 10.1590/s1983-14472011000100019 [doi]
PST - ppublish
SO  - Rev Gaucha Enferm. 2011 Mar;32(1):143-50. doi: 10.1590/s1983-14472011000100019.


PMID- 21888210
OWN - NLM
STAT- MEDLINE
DCOM- 20111027
LR  - 20191112
IS  - 0102-6933 (Print)
IS  - 0102-6933 (Linking)
VI  - 32
IP  - 1
DP  - 2011 Mar
TI  - [Sexual orientation in the school environment: fact or eagerness?].
PG  - 107-13
AB  - This qualitative research aims to analyze how sexual orientation has been
      incorporated into pedagogic practices through the point of view of educators from
      public schools of fundamental teaching. Twenty three educators from Cajazeiras,
      Paralba, Brazil participated in the study. The focus group was elected as
      technique of investigation, and the empirical data obtained were organized
      according to the technique of analysis of content. It was realized that there is 
      an effort of the actors to privilege contents related to sexual orientation in
      the school environment though they demand that a level of informative and
      subjective character about the "sexuality" be encouraged providing the educators 
      with a space for re-significations of its internality of values. The information 
      directed to self-care must transcend the limits of prevention and hygienisation, 
      incorporating extensive, inclusive and reflective methodologies, which recognize 
      human and social rights and promote the ethical construction of citizenship.
FAU - de Almeida, Sandra Aparecida
AU  - de Almeida SA
AD  - Universidade Federal da Paraiba, Brasil. sandra_almeida09@yahoo.com.br
FAU - Nogueira, Jordana de Almeida
AU  - Nogueira Jde A
FAU - Silva, Antonia Oliveira
AU  - Silva AO
FAU - Torres, Gilson Vasconcelos
AU  - Torres GV
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Orientacaao sexual nas escolas: fato ou anseio?
PL  - Brazil
TA  - Rev Gaucha Enferm
JT  - Revista gaucha de enfermagem
JID - 8504882
MH  - *Attitude
MH  - *Faculty
MH  - Humans
MH  - *Sex Education
MH  - *Sexual Behavior
EDAT- 2011/09/06 06:00
MHDA- 2011/10/28 06:00
CRDT- 2011/09/06 06:00
PHST- 2011/09/06 06:00 [entrez]
PHST- 2011/09/06 06:00 [pubmed]
PHST- 2011/10/28 06:00 [medline]
AID - 10.1590/s1983-14472011000100014 [doi]
PST - ppublish
SO  - Rev Gaucha Enferm. 2011 Mar;32(1):107-13. doi: 10.1590/s1983-14472011000100014.


PMID- 21888005
OWN - NLM
STAT- MEDLINE
DCOM- 20110915
LR  - 20110905
IS  - 0844-5621 (Print)
IS  - 0844-5621 (Linking)
VI  - 43
IP  - 2
DP  - 2011 Jun
TI  - Remote nursing certified practice: viewing nursing and nurse practitioner
      practice through a social justice lens.
PG  - 38-61
AB  - Remote Nursing Certified Practice (RNCP) was introduced in 2010 to regulate
      nursing practice in remote, largely First Nations communities in British
      Columbia, Canada. These are communities that often experience profound health and
      health-care inequities. Typically nurses are the main health-care providers.
      Using a critical social justice lens, the authors explore the clinical and
      ethical implications of RNCP in terms of access to equitable, high-quality
      primary health care.They examine the fit between the level and scope of health
      services provided by registered nurses working under RNCP and the health needs of
      remote First Nations communities. In doing so, they draw comparisons between
      nurse practitioners (NPs) and outpost nurses working in NP roles who historically
      were employed to provide health care in these communities.The authors conclude by
      calling for nursing regulations that support equitable, high-quality primary care
      for all British Columbians.
FAU - Tarlier, Denise S
AU  - Tarlier DS
AD  - School of Nursing, Thompson Rivers University, Kamloops, British Columbia,
      Canada.
FAU - Browne, Annette J
AU  - Browne AJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Can J Nurs Res
JT  - The Canadian journal of nursing research = Revue canadienne de recherche en
      sciences infirmieres
JID - 8910581
MH  - British Columbia
MH  - Health Services Accessibility
MH  - *Nurse Practitioners
MH  - *Nursing
MH  - *Rural Health Services
MH  - *Social Justice
EDAT- 2011/09/06 06:00
MHDA- 2011/09/16 06:00
CRDT- 2011/09/06 06:00
PHST- 2011/09/06 06:00 [entrez]
PHST- 2011/09/06 06:00 [pubmed]
PHST- 2011/09/16 06:00 [medline]
PST - ppublish
SO  - Can J Nurs Res. 2011 Jun;43(2):38-61.


PMID- 21888004
OWN - NLM
STAT- MEDLINE
DCOM- 20110915
LR  - 20140325
IS  - 0844-5621 (Print)
IS  - 0844-5621 (Linking)
VI  - 43
IP  - 2
DP  - 2011 Jun
TI  - Advance care planning: re-visioning our ethical approach.
PG  - 18-37
AB  - This qualitative study explored the applicability and usefulness of a promising
      advance care planning (ACP) intervention and examined the ACP process. Nine dyads
      (patients newly diagnosed with advanced lung cancer and a family member)
      participated in the ACP intervention, with evaluative interviews at 3 and 6
      months after the intervention. All interviews were recorded, transcribed
      verbatim, and analyzed using constant comparison. The process was found not to be
      one of preparing a substitute decision-maker to speak for oneself and direct
      health care at a time when one is incapacitated; rather, the families engaged in 
      a deeply relational process where meaning, values, and preferences were
      negotiated in conversation. ACP is theoretically rooted in a traditional notion
      of patient autonomy that is not aligned with the relational process that unfolded
      in this study. An approach that embraces relational autonomy is more congruent
      and provides a stronger foundation for meeting the needs of families.
FAU - Robinson, Carole A
AU  - Robinson CA
AD  - School of Nursing, Faculty of Health and Social Development, University of
      British Columbia, Kelowna, Canada.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Can J Nurs Res
JT  - The Canadian journal of nursing research = Revue canadienne de recherche en
      sciences infirmieres
JID - 8910581
MH  - *Advance Care Planning
MH  - Canada
MH  - *Ethics, Nursing
MH  - Freedom
MH  - Humans
MH  - Lung Neoplasms/nursing
EDAT- 2011/09/06 06:00
MHDA- 2011/09/16 06:00
CRDT- 2011/09/06 06:00
PHST- 2011/09/06 06:00 [entrez]
PHST- 2011/09/06 06:00 [pubmed]
PHST- 2011/09/16 06:00 [medline]
PST - ppublish
SO  - Can J Nurs Res. 2011 Jun;43(2):18-37.


PMID- 21888002
OWN - NLM
STAT- MEDLINE
DCOM- 20110915
LR  - 20110905
IS  - 0844-5621 (Print)
IS  - 0844-5621 (Linking)
VI  - 43
IP  - 2
DP  - 2011 Jun
TI  - Nursing inquiry to address pressing empirical and ethical questions.
PG  - 7-10
FAU - Rodney, Patricia
AU  - Rodney P
LA  - eng
PT  - Editorial
PT  - Introductory Journal Article
PL  - United States
TA  - Can J Nurs Res
JT  - The Canadian journal of nursing research = Revue canadienne de recherche en
      sciences infirmieres
JID - 8910581
MH  - Canada
MH  - Empirical Research
MH  - *Ethics, Nursing
MH  - *Nursing Research
EDAT- 2011/09/06 06:00
MHDA- 2011/09/16 06:00
CRDT- 2011/09/06 06:00
PHST- 2011/09/06 06:00 [entrez]
PHST- 2011/09/06 06:00 [pubmed]
PHST- 2011/09/16 06:00 [medline]
PST - ppublish
SO  - Can J Nurs Res. 2011 Jun;43(2):7-10.


PMID- 21887135
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1662-5145 (Electronic)
IS  - 1662-5145 (Linking)
VI  - 5
DP  - 2011
TI  - Origin and evolution of deep brain stimulation.
PG  - 42
LID - 10.3389/fnint.2011.00042 [doi]
AB  - This paper briefly describes how the electrical stimulation, used since antiquity
      to modulate the nervous system, has been a fundamental tool of neurophysiologic
      investigation in the second half of the eighteenth century and was subsequently
      used by the early twentieth century, even for therapeutic purposes. In
      mid-twentieth century the advent of stereotactic procedures has allowed the drift
      from lesional to stimulating technique of deep nuclei of the brain for
      therapeutic purposes. In this way, deep brain stimulation (DBS) was born, that,
      over the last two decades, has led to positive results for the treatment of
      medically refractory Parkinson's disease, essential tremor, and dystonia. In
      recent years, the indications for therapeutic use of DBS have been extended to
      epilepsy, Tourette's syndrome, psychiatric diseases (depression,
      obsessive-compulsive disorder), some kinds of headache, eating disorders, and the
      minimally conscious state. The potentials of the DBS for therapeutic use are
      fascinating, but there are still many unresolved technical and ethical problems, 
      concerning the identification of the targets for each disease, the selection of
      the patients and the evaluation of the results.
FAU - Sironi, Vittorio A
AU  - Sironi VA
AD  - Research Institute on the History of Biomedical Thought, University of Milano
      Bicocca Milan, Italy.
LA  - eng
PT  - Journal Article
DEP - 20110818
PL  - Switzerland
TA  - Front Integr Neurosci
JT  - Frontiers in integrative neuroscience
JID - 101477950
PMC - PMC3157831
OTO - NOTNLM
OT  - bioethics
OT  - cerebral localization
OT  - deep brain stimulation
OT  - history
OT  - neuronal devices
OT  - stereotactic neurosurgery
EDAT- 2011/09/03 06:00
MHDA- 2011/09/03 06:01
CRDT- 2011/09/03 06:00
PHST- 2011/01/26 00:00 [received]
PHST- 2011/08/02 00:00 [accepted]
PHST- 2011/09/03 06:00 [entrez]
PHST- 2011/09/03 06:00 [pubmed]
PHST- 2011/09/03 06:01 [medline]
AID - 10.3389/fnint.2011.00042 [doi]
PST - epublish
SO  - Front Integr Neurosci. 2011 Aug 18;5:42. doi: 10.3389/fnint.2011.00042.
      eCollection 2011.


PMID- 21886583
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1875-6190 (Electronic)
IS  - 1570-159X (Linking)
VI  - 9
IP  - 1
DP  - 2011 Mar
TI  - No Association Between GRM3 and Japanese Methamphetamine-Induced Psychosis.
PG  - 160-2
LID - 10.2174/157015911795017001 [doi]
AB  - UNLABELLED: Several investigations have suggested that abnormalities in glutamate
      neural transmission play a role in the pathophysiology of psychiatric disorders, 
      including schizophrenia. The metabotropic glutamate 3 receptor (mGluR3) gene was 
      reported to be associated with schizophrenia, and paranoid type schizophrenia has
      symptoms that are similar to those of methamphetamine-induced psychosis. This
      suggests that mGluR3 gene (GRM3) is a good candidate gene for the pathogenesis of
      methamphetamine-induced psychosis. To evaluate the association between GRM3 and
      methamphetamine-induced psychosis, we conducted a case-control study of Japanese 
      samples (181 methamphetamine-induced psychosis and 232 controls). METHODS: We
      selected one functional SNP (rs6465084), reported to be associated with
      prefrontal brain functioning, for an association analysis. Written informed
      consent was obtained from each subject. This study was approved by the ethics
      committees at Fujita Health University, Nagoya University Graduate School of
      Medicine and each participating member of the Institute of the Japanese Genetics 
      Initiative for Drug Abuse (JGIDA). RESULTS: We did not detect an association
      between rs6465084 in GRM3 and Japanese methamphetamine-induced psychosis.
      CONCLUSION: Our findings suggest that rs6465084 in GRM3 does not play a major
      role in the pathophysiology of methamphetamine-induced psychosis in the Japanese 
      population. However, because we did not perform an association analysis based on 
      linkage disequilibrium (LD) or a mutation scan of GRM3, a replication study using
      a larger sample and based on LD may be required for conclusive results.
FAU - Tsunoka, Tomoko
AU  - Tsunoka T
AD  - Department of Psychiatry, Fujita Health University School of Medicine, Toyoake,
      Aichi 470-1192, Japan.
FAU - Kishi, Taro
AU  - Kishi T
FAU - Ikeda, Masashi
AU  - Ikeda M
FAU - Kitajima, Tsuyoshi
AU  - Kitajima T
FAU - Yamanouchi, Yoshio
AU  - Yamanouchi Y
FAU - Kinoshita, Yoko
AU  - Kinoshita Y
FAU - Kawashima, Kunihiro
AU  - Kawashima K
FAU - Okochi, Tomo
AU  - Okochi T
FAU - Okumura, Takenori
AU  - Okumura T
FAU - Inada, Toshiya
AU  - Inada T
FAU - Ujike, Hiroshi
AU  - Ujike H
FAU - Yamada, Mitsuhiko
AU  - Yamada M
FAU - Uchimura, Naohisa
AU  - Uchimura N
FAU - Sora, Ichiro
AU  - Sora I
FAU - Iyo, Masaomi
AU  - Iyo M
FAU - Ozaki, Norio
AU  - Ozaki N
FAU - Iwata, Nakao
AU  - Iwata N
LA  - eng
PT  - Journal Article
PL  - United Arab Emirates
TA  - Curr Neuropharmacol
JT  - Current neuropharmacology
JID - 101157239
PMC - PMC3137173
OTO - NOTNLM
OT  - GRM3
OT  - Methamphetamine-Induced Psychosis
OT  - case-control study.
EDAT- 2011/09/03 06:00
MHDA- 2011/09/03 06:01
CRDT- 2011/09/03 06:00
PHST- 2009/10/01 00:00 [received]
PHST- 2010/04/17 00:00 [revised]
PHST- 2010/05/26 00:00 [accepted]
PHST- 2011/09/03 06:00 [entrez]
PHST- 2011/09/03 06:00 [pubmed]
PHST- 2011/09/03 06:01 [medline]
AID - 10.2174/157015911795017001 [doi]
AID - CN-9-160 [pii]
PST - ppublish
SO  - Curr Neuropharmacol. 2011 Mar;9(1):160-2. doi: 10.2174/157015911795017001.


PMID- 21886582
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1875-6190 (Electronic)
IS  - 1570-159X (Linking)
VI  - 9
IP  - 1
DP  - 2011 Mar
TI  - Genetic Association Analysis of NOS1 and Methamphetamine-Induced Psychosis Among 
      Japanese.
PG  - 155-9
LID - 10.2174/157015911795017308 [doi]
AB  - The neuronal nitric oxide synthase gene (NOS1) is located at 12q24, a
      susceptibility region for schizophrenia, and produces nitric oxide (NO). NO has
      been reported to play important roles as a gaseous neurotransmitter in brain. NO 
      is a second messenger for the N-methyl-D aspartate (NMDA) receptor and is related
      to the dopaminergic system. Because the symptomatology of methamphetamine (METH) 
      use disorder patients with psychosis is similar to that of patients with
      schizophrenia, NOS1 is a good candidate gene for METH-induced psychosis.
      Therefore, we conducted a case-control association study between NOS1 and
      METH-induced psychosis with Japanese subjects (183 with METH-induced psychosis
      patients and 519 controls). We selected seven SNPs (rs41279104, rs3782221,
      rs3782219, rs561712, rs3782206, rs6490121, rs2682826) in NOS1 from previous
      reports. Written informed consent was obtained from each subject. This study was 
      approved by the Ethics Committee at Fujita Health University School of Medicine
      and each participating institute of the Japanese Genetics Initiative for Drug
      Abuse (JGIDA). No significant association was found between NOS1 and METH-induced
      psychosis in the allele/genotype-wise or haplotype-wise analyses. In conclusion, 
      we suggest that NOS1 might not contribute to the risk of METH-induced psychosis
      in the Japanese population.
FAU - Okumura, Takenori
AU  - Okumura T
AD  - Department of Psychiatry, Fujita Health University School of Medicine, Toyoake,
      Japan.
FAU - Okochi, Tomo
AU  - Okochi T
FAU - Kishi, Taro
AU  - Kishi T
FAU - Ikeda, Masashi
AU  - Ikeda M
FAU - Kitajima, Tsuyoshi
AU  - Kitajima T
FAU - Kinoshita, Yoko
AU  - Kinoshita Y
FAU - Kawashima, Kunihiro
AU  - Kawashima K
FAU - Tsunoka, Tomoko
AU  - Tsunoka T
FAU - Fukuo, Yasuhisa
AU  - Fukuo Y
FAU - Inada, Toshiya
AU  - Inada T
FAU - Yamada, Mitsuhiko
AU  - Yamada M
FAU - Uchimura, Naohisa
AU  - Uchimura N
FAU - Iyo, Masaomi
AU  - Iyo M
FAU - Sora, Ichiro
AU  - Sora I
FAU - Ozaki, Norio
AU  - Ozaki N
FAU - Ujike, Hiroshi
AU  - Ujike H
FAU - Iwata, Nakao
AU  - Iwata N
LA  - eng
PT  - Journal Article
PL  - United Arab Emirates
TA  - Curr Neuropharmacol
JT  - Current neuropharmacology
JID - 101157239
PMC - PMC3137172
OTO - NOTNLM
OT  - Methamphetamine-induced psychosis
OT  - case-control association study.
OT  - neuronal nitric oxide synthase 1 gene (NOS1)
EDAT- 2011/09/03 06:00
MHDA- 2011/09/03 06:01
CRDT- 2011/09/03 06:00
PHST- 2009/10/01 00:00 [received]
PHST- 2010/04/17 00:00 [revised]
PHST- 2010/05/26 00:00 [accepted]
PHST- 2011/09/03 06:00 [entrez]
PHST- 2011/09/03 06:00 [pubmed]
PHST- 2011/09/03 06:01 [medline]
AID - 10.2174/157015911795017308 [doi]
AID - CN-9-155 [pii]
PST - ppublish
SO  - Curr Neuropharmacol. 2011 Mar;9(1):155-9. doi: 10.2174/157015911795017308.


PMID- 21886578
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1875-6190 (Electronic)
IS  - 1570-159X (Linking)
VI  - 9
IP  - 1
DP  - 2011 Mar
TI  - Lack of association between prokineticin 2 gene and Japanese methamphetamine
      dependence.
PG  - 133-6
LID - 10.2174/157015911795016994 [doi]
AB  - Disruption of circadian rhythms may be involved in the pathophysiology of
      psychiatric disorders, including drug addiction. Recently, we detected the
      significant association between prokineticin 2 receptor gene (PROKR2) and
      Japanese methamphetamine dependence patients. Also, prokineticin 2 (PK2) gene
      deficient mice showed reduced physiological and behavioral parameters, including 
      circadian locomotor activity, circulating glucocorticoid, glucose levels and the 
      expression of peripheral clock genes compared with WT mice. These evidences
      indicate that PK2 gene (PROK2) is a good candidate gene for the pathogenesis of
      methamphetamine dependence. To evaluate the association between PROK2 and
      methamphetamine dependence, we conducted a case-control study of Japanese samples
      (215 methamphetamine dependence and 232 controls) with four tagging SNPs selected
      by HapMap database. The age and sex of the control subjects did not differ from
      those of the methamphetamine dependence patients. Written informed consent was
      obtained from each subject. This study was approved by the ethics committees at
      Fujita Health University, Nagoya University Graduate School of Medicine and each 
      participating member of the Institute of the Japanese Genetics Initiative for
      Drug Abuse (JGIDA). We did not detect an association between PROK2 and Japanese
      methamphetamine dependence patients in allele/genotype-wise analysis, or the
      haplotype analysis. Our findings suggest that PROK2 does not play a major role in
      the pathophysiology of methamphetamine dependence in the Japanese population.
FAU - Kishi, Taro
AU  - Kishi T
AD  - Department of Psychiatry, Fujita Health University School of Medicine, Toyoake,
      Aichi 470-1192, Japan.
FAU - Kitajima, Tsuyoshi
AU  - Kitajima T
FAU - Tsunoka, Tomoko
AU  - Tsunoka T
FAU - Okumura, Takenori
AU  - Okumura T
FAU - Kawashima, Kunihiro
AU  - Kawashima K
FAU - Okochi, Tomo
AU  - Okochi T
FAU - Yamanouchi, Yoshio
AU  - Yamanouchi Y
FAU - Kinoshita, Yoko
AU  - Kinoshita Y
FAU - Ujike, Hiroshi
AU  - Ujike H
FAU - Inada, Toshiya
AU  - Inada T
FAU - Yamada, Mitsuhiko
AU  - Yamada M
FAU - Uchimura, Naohisa
AU  - Uchimura N
FAU - Sora, Ichiro
AU  - Sora I
FAU - Iyo, Masaomi
AU  - Iyo M
FAU - Ozaki, Norio
AU  - Ozaki N
FAU - Iwata, Nakao
AU  - Iwata N
LA  - eng
PT  - Journal Article
PL  - United Arab Emirates
TA  - Curr Neuropharmacol
JT  - Current neuropharmacology
JID - 101157239
PMC - PMC3137168
OTO - NOTNLM
OT  - Prokineticin 2 gene (PROK2)
OT  - linkage disequilibrium.
OT  - methamphetamine dependence
OT  - tagging SNPs
EDAT- 2011/09/03 06:00
MHDA- 2011/09/03 06:01
CRDT- 2011/09/03 06:00
PHST- 2009/10/01 00:00 [received]
PHST- 2010/04/17 00:00 [revised]
PHST- 2010/05/26 00:00 [accepted]
PHST- 2011/09/03 06:00 [entrez]
PHST- 2011/09/03 06:00 [pubmed]
PHST- 2011/09/03 06:01 [medline]
AID - 10.2174/157015911795016994 [doi]
AID - CN-9-133 [pii]
PST - ppublish
SO  - Curr Neuropharmacol. 2011 Mar;9(1):133-6. doi: 10.2174/157015911795016994.


PMID- 21886577
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1875-6190 (Electronic)
IS  - 1570-159X (Linking)
VI  - 9
IP  - 1
DP  - 2011 Mar
TI  - Association Analysis of Nuclear Receptor Rev-erb Alpha Gene (NR1D1) and Japanese 
      Methamphetamine Dependence.
PG  - 129-32
LID - 10.2174/157015911795017065 [doi]
AB  - Several investigations suggested abnormalities in circadian rhythms are related
      to the pathophysiology of psychiatric disorders, including drug addiction.
      Recently, orphan nuclear receptor rev-erb alpha and glycogen synthase kinase-3
      beta (GSK-3beta) were shown to be important circadian components. In addition,
      the orphan nuclear receptor rev-erb alpha is a key negative feedback regulator of
      the circadian clock. These evidences indicate that rev-erb alpha gene (NR1D1) is 
      a good candidate gene for the pathogenesis of methamphetamine dependence. To
      evaluate the association between NR1D1 and methamphetamine dependence, we
      conducted a case-control study of Japanese samples (215 methamphetamine
      dependence and 232 controls) with three tagging SNPs selected by HapMap database.
      Written informed consent was obtained from each subject. This study was approved 
      by the ethics committees at Fujita Health University, Nagoya University Graduate 
      School of Medicine and each participating member of the Institute of the Japanese
      Genetics Initiative for Drug Abuse (JGIDA). We did not detect an association
      between NR1D1 and Japanese methamphetamine dependence patients in
      allele/genotype-wise analysis, or the haplotype analysis. Our findings suggest
      that NR1D1 does not play a major role in the pathophysiology of methamphetamine
      dependence in the Japanese population.
FAU - Kishi, Taro
AU  - Kishi T
AD  - Department of Psychiatry, Fujita Health University School of Medicine, Toyoake,
      Aichi 470-1192, Japan.
FAU - Kitajima, Tsuyoshi
AU  - Kitajima T
FAU - Kawashima, Kunihiro
AU  - Kawashima K
FAU - Okochi, Tomo
AU  - Okochi T
FAU - Yamanouchi, Yoshio
AU  - Yamanouchi Y
FAU - Kinoshita, Yoko
AU  - Kinoshita Y
FAU - Ujike, Hiroshi
AU  - Ujike H
FAU - Inada, Toshiya
AU  - Inada T
FAU - Yamada, Mitsuhiko
AU  - Yamada M
FAU - Uchimura, Naohisa
AU  - Uchimura N
FAU - Sora, Ichiro
AU  - Sora I
FAU - Iyo, Masaomi
AU  - Iyo M
FAU - Ozaki, Norio
AU  - Ozaki N
FAU - Iwata, Nakao
AU  - Iwata N
LA  - eng
PT  - Journal Article
PL  - United Arab Emirates
TA  - Curr Neuropharmacol
JT  - Current neuropharmacology
JID - 101157239
PMC - PMC3137167
OTO - NOTNLM
OT  - Orphan nuclear receptor Rev-erb alpha gene (NR1D1)
OT  - linkage disequilibrium.
OT  - methamphetamine dependence
OT  - tagging SNPs
EDAT- 2011/09/03 06:00
MHDA- 2011/09/03 06:01
CRDT- 2011/09/03 06:00
PHST- 2009/10/01 00:00 [received]
PHST- 2010/04/17 00:00 [revised]
PHST- 2010/05/26 00:00 [accepted]
PHST- 2011/09/03 06:00 [entrez]
PHST- 2011/09/03 06:00 [pubmed]
PHST- 2011/09/03 06:01 [medline]
AID - 10.2174/157015911795017065 [doi]
AID - CN-9-129 [pii]
PST - ppublish
SO  - Curr Neuropharmacol. 2011 Mar;9(1):129-32. doi: 10.2174/157015911795017065.


PMID- 21886138
OWN - NLM
STAT- MEDLINE
DCOM- 20110908
LR  - 20211020
IS  - 1476-4687 (Electronic)
IS  - 0028-0836 (Linking)
VI  - 477
IP  - 7362
DP  - 2011 Aug 31
TI  - Work ethic: The 24/7 lab.
PG  - 20-2
LID - 10.1038/477020a [doi]
FAU - Ledford, Heidi
AU  - Ledford H
LA  - eng
PT  - News
DEP - 20110831
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
SB  - IM
MH  - Education, Graduate/standards/trends
MH  - *Ethics, Research
MH  - Research/*standards/trends
EDAT- 2011/09/03 06:00
MHDA- 2011/09/09 06:00
CRDT- 2011/09/03 06:00
PHST- 2011/09/03 06:00 [entrez]
PHST- 2011/09/03 06:00 [pubmed]
PHST- 2011/09/09 06:00 [medline]
AID - 477020a [pii]
AID - 10.1038/477020a [doi]
PST - epublish
SO  - Nature. 2011 Aug 31;477(7362):20-2. doi: 10.1038/477020a.


PMID- 21885749
OWN - NLM
STAT- MEDLINE
DCOM- 20110914
LR  - 20110902
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Linking)
VI  - 333
IP  - 6047
DP  - 2011 Sep 2
TI  - Human subjects research. Panel blasts ethics, science of 1940s Guatemala studies.
PG  - 1211
LID - 10.1126/science.333.6047.1211 [doi]
FAU - Kaiser, Jocelyn
AU  - Kaiser J
LA  - eng
PT  - Historical Article
PT  - News
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Penicillins)
SB  - IM
MH  - Anti-Bacterial Agents/therapeutic use
MH  - *Ethics, Research
MH  - Guatemala
MH  - History, 20th Century
MH  - Humans
MH  - *Informed Consent
MH  - Military Personnel
MH  - Nontherapeutic Human Experimentation/ethics/*history
MH  - Penicillins/therapeutic use
MH  - Sexually Transmitted Diseases/*history/prevention & control
MH  - United States
MH  - United States Public Health Service/history
EDAT- 2011/09/03 06:00
MHDA- 2011/09/15 06:00
CRDT- 2011/09/03 06:00
PHST- 2011/09/03 06:00 [entrez]
PHST- 2011/09/03 06:00 [pubmed]
PHST- 2011/09/15 06:00 [medline]
AID - 333/6047/1211 [pii]
AID - 10.1126/science.333.6047.1211 [doi]
PST - ppublish
SO  - Science. 2011 Sep 2;333(6047):1211. doi: 10.1126/science.333.6047.1211.


PMID- 21885658
OWN - NLM
STAT- MEDLINE
DCOM- 20120326
LR  - 20161020
IS  - 1526-3347 (Electronic)
IS  - 0191-9601 (Linking)
VI  - 32
IP  - 9
DP  - 2011 Sep
TI  - Ethics for the pediatrician: religion and spirituality in pediatrics.
PG  - e91-4
LID - 10.1542/pir.32-9-e91 [doi]
FAU - Yates, Ferdinand D Jr
AU  - Yates FD Jr
AD  - Department of Pediatrics, School of Medicine and Biomedical Sciences, State
      University of New York at Buffalo, Buffalo, NY, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Pediatr Rev
JT  - Pediatrics in review
JID - 8103046
SB  - IM
MH  - Humans
MH  - Patient Care/ethics
MH  - Pediatrics/*ethics
MH  - Physician-Patient Relations/ethics
MH  - *Religion and Medicine
MH  - *Spirituality
EDAT- 2011/09/03 06:00
MHDA- 2012/03/27 06:00
CRDT- 2011/09/03 06:00
PHST- 2011/09/03 06:00 [entrez]
PHST- 2011/09/03 06:00 [pubmed]
PHST- 2012/03/27 06:00 [medline]
AID - 32/9/e91 [pii]
AID - 10.1542/pir.32-9-e91 [doi]
PST - ppublish
SO  - Pediatr Rev. 2011 Sep;32(9):e91-4. doi: 10.1542/pir.32-9-e91.


PMID- 21885448
OWN - NLM
STAT- MEDLINE
DCOM- 20111229
LR  - 20111102
IS  - 1538-6724 (Electronic)
IS  - 0031-9023 (Linking)
VI  - 91
IP  - 11
DP  - 2011 Nov
TI  - Moral agency as enacted justice: a clinical and ethical decision-making framework
      for responding to health inequities and social injustice.
PG  - 1653-63
LID - 10.2522/ptj.20100351.20 [doi]
AB  - This is the second of 2 companion articles in this issue. The first article
      explored the clinical and ethical implications of new emphases in physical
      therapy codes of conduct reflecting the growing evidence regarding the importance
      of social determinants of health, epidemiological trends for health service
      delivery, and the enhanced participation of physical therapists in shaping health
      care reform in a number of international contexts. The first article was
      theoretically oriented and proposed that a re-thinking of ethical frameworks
      expressed in codes of ethics could both inform and underpin practical strategies 
      for working in primary health care. A review of the ethical principle of
      "justice," which, arguably, remains the least consensually understood and
      developed principle in the ethics literature of physical therapy, was provided,
      and a more recent perspective-the capability approach to justice-was discussed.
      The current article proposes a clinical and ethical decision-making framework,
      the ethical reasoning bridge (ER bridge), which can be used to assist physical
      therapy practitioners to: (1) understand and implement the capability approach to
      justice at a clinical level; (2) reflect on and evaluate both the fairness and
      influence of beliefs, perspectives, and context affecting health and disability
      through a process of "wide reflective equilibrium" and assist patients to do this
      as well; and (3) nurture the development of moral agency, in partnership with
      patients, through a transformative learning process manifest in a mutual
      "crossing" and "re-crossing" of the ER bridge. It is proposed that the
      development and exercise of moral agency represent an enacted justice that is the
      result of a shared reasoning and learning experience on the part of both
      therapists and patients.
FAU - Edwards, Ian
AU  - Edwards I
AD  - School of Health Sciences, Internal Post Code CEA-14, University of South
      Australia, GPO Box 2741, Adelaide, South Australia, Australia 5001.
      ian.edwards@unisa.edu.au
FAU - Delany, Clare M
AU  - Delany CM
FAU - Townsend, Anne F
AU  - Townsend AF
FAU - Swisher, Laura Lee
AU  - Swisher LL
LA  - eng
PT  - Journal Article
DEP - 20110901
PL  - United States
TA  - Phys Ther
JT  - Physical therapy
JID - 0022623
SB  - IM
MH  - *Decision Making
MH  - *Ethics, Clinical
MH  - Humans
MH  - Models, Theoretical
MH  - *Morals
MH  - *Physical Therapy Specialty
MH  - *Social Justice
EDAT- 2011/09/03 06:00
MHDA- 2011/12/30 06:00
CRDT- 2011/09/03 06:00
PHST- 2011/09/03 06:00 [entrez]
PHST- 2011/09/03 06:00 [pubmed]
PHST- 2011/12/30 06:00 [medline]
AID - ptj.20100351.20 [pii]
AID - 10.2522/ptj.20100351.20 [doi]
PST - ppublish
SO  - Phys Ther. 2011 Nov;91(11):1653-63. doi: 10.2522/ptj.20100351.20. Epub 2011 Sep
      1.


PMID- 21885447
OWN - NLM
STAT- MEDLINE
DCOM- 20111229
LR  - 20111102
IS  - 1538-6724 (Electronic)
IS  - 0031-9023 (Linking)
VI  - 91
IP  - 11
DP  - 2011 Nov
TI  - New perspectives on the theory of justice: implications for physical therapy
      ethics and clinical practice.
PG  - 1642-52
LID - 10.2522/ptj.20100351.10 [doi]
AB  - Recent revisions of physical therapy codes of ethics have included a new emphasis
      concerning health inequities and social injustice. This emphasis reflects the
      growing evidence regarding the importance of social determinants of health,
      epidemiological trends for health service delivery, and the enhanced
      participation of physical therapists in shaping health care reform in a number of
      international contexts. This perspective article suggests that there is a
      "disconnect" between the societal obligations and aspirations expressed in the
      revised codes and the individualist ethical frameworks that predominantly
      underpin them. Primary health care is an approach to health care arising from an 
      understanding of the nexus between health and social disadvantage that considers 
      the health needs of patients as expressive of the health needs of the communities
      of which they are members. It is proposed that re-thinking ethical frameworks
      expressed in codes of ethics can both inform and underpin practical strategies
      for working in primary health care. This perspective article provides a new focus
      on the ethical principle of justice: the ethical principle that arguably remains 
      the least consensually understood and developed in the ethics literature of
      physical therapy. A relatively recent theory of justice known as the "capability 
      approach to justice" is discussed, along with its potential to assist physical
      therapy practitioners to further develop moral agency in order to address
      situations of health inequity and social injustice in clinical practice.
FAU - Edwards, Ian
AU  - Edwards I
AD  - School of Health Sciences, Internal Post Code CEA-14, University of South
      Australia, GPO Box 2741, Adelaide, South Australia, Australia 5001.
      ian.edwards@unisa.edu.au
FAU - Delany, Clare M
AU  - Delany CM
FAU - Townsend, Anne F
AU  - Townsend AF
FAU - Swisher, Laura Lee
AU  - Swisher LL
LA  - eng
PT  - Journal Article
DEP - 20110901
PL  - United States
TA  - Phys Ther
JT  - Physical therapy
JID - 0022623
SB  - IM
MH  - *Codes of Ethics
MH  - *Ethics, Clinical
MH  - Humans
MH  - Models, Theoretical
MH  - Morals
MH  - *Physical Therapy Specialty
MH  - *Social Justice
EDAT- 2011/09/03 06:00
MHDA- 2011/12/30 06:00
CRDT- 2011/09/03 06:00
PHST- 2011/09/03 06:00 [entrez]
PHST- 2011/09/03 06:00 [pubmed]
PHST- 2011/12/30 06:00 [medline]
AID - ptj.20100351.10 [pii]
AID - 10.2522/ptj.20100351.10 [doi]
PST - ppublish
SO  - Phys Ther. 2011 Nov;91(11):1642-52. doi: 10.2522/ptj.20100351.10. Epub 2011 Sep
      1.


PMID- 21885150
OWN - NLM
STAT- MEDLINE
DCOM- 20130318
LR  - 20121015
IS  - 1872-7565 (Electronic)
IS  - 0169-2607 (Linking)
VI  - 108
IP  - 2
DP  - 2012 Nov
TI  - First pilot trial of the STAR-Liege protocol for tight glycemic control in
      critically ill patients.
PG  - 844-59
LID - 10.1016/j.cmpb.2011.07.003 [doi]
LID - S0169-2607(11)00191-X [pii]
AB  - Tight glycemic control (TGC) has shown benefits in ICU patients, but been
      difficult to achieve consistently due to inter- and intra- patient variability
      that requires more adaptive, patient-specific solutions. STAR (Stochastic
      TARgeted) is a flexible model-based TGC framework accounting for patient
      variability with a stochastically derived maximum 5% risk of blood glucose (BG)
      below 72 mg/dL. This research describes the first clinical pilot trial of the
      STAR approach and the post-trial analysis of the models and methods that underpin
      the protocol. The STAR framework works with clinically specified targets and
      intervention guidelines. The clinically specified glycemic target was 125 mg/dL. 
      Each trial was 24 h with BG measured 1-2 hourly. Two-hourly measurement was used 
      when BG was between 110-135 mg/dL for 3 h. In the STAR approach, each
      intervention leads to a predicted BG level and outcome range (5-95th percentile) 
      based on a stochastic model of metabolic patient variability. Carbohydrate intake
      (all sources) was monitored, but not changed from clinical settings except to
      prevent BG<100 mg/dL when no insulin was given. Insulin infusion rates were
      limited (6 U/h maximum), with limited increases based on current infusion rate
      (0.5-2.0 U/h), making this use of the STAR framework an insulin-only TGC
      approach. Approval was granted by the Ethics Committee of the Medical Faculty of 
      the University of Liege (Liege, Belgium). Nine patient trials were undertaken
      after obtaining informed consent. There were 205 measurements over all 9 trials. 
      Median [IQR] per-patient results were: BG: 138.5 [130.6-146.0]mg/dL; carbohydrate
      administered: 2-11 g/h; median insulin:1.3 [0.9-2.4]U/h with a maximum of 6.0
      [4.7-6.0]U/h. Median [IQR] time in the desired 110-140 mg/dL band was: 50.0
      [31.2-54.2]%. Median model prediction errors ranged: 10-18%, with larger errors
      due to small meals and other clinical events. The minimum BG was 63 mg/dL and no 
      other measurement was below 72 mg/dL, so only 1 measurement (0.5%) was below the 
      5% guaranteed minimum risk level. Post-trial analysis showed that patients were
      more variable than predicted by the stochastic model used for control, resulting 
      in some of the prediction errors seen. Analysis and (validated) virtual trial
      re-simulating the clinical trial using stochastic models relevant to the
      patient's particular day of ICU stay were seen to be more accurate in capturing
      the observed variability. This analysis indicated that equivalent control and
      safety could be obtained with similar or lower glycemic variability in control
      using more specific stochastic models. STAR effectively controlled all patients
      to target. Observed patient variability in response to insulin and thus
      prediction errors were higher than expected, likely due to the recent insult of
      cardiac surgery or a major cardiac event, and their immediate recovery. STAR
      effectively managed this variability with no hypoglycemia. Improved stochastic
      models will be used to prospectively test these outcomes in further ongoing
      clinical pilot trials in this and other units.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Penning, Sophie
AU  - Penning S
AD  - Cardiovascular Research Centre, Institut de Physique, Universite de Liege,
      Department of Intensive Care, Liege University Hospital, Allee du 6 Aout, 17 (Bat
      B5), B4000 Liege, Belgium. sophie.penning@ulg.ac.be
FAU - Le Compte, Aaron J
AU  - Le Compte AJ
FAU - Moorhead, Katherine T
AU  - Moorhead KT
FAU - Desaive, Thomas
AU  - Desaive T
FAU - Massion, Paul
AU  - Massion P
FAU - Preiser, Jean-Charles
AU  - Preiser JC
FAU - Shaw, Geoffrey M
AU  - Shaw GM
FAU - Chase, J Geoffrey
AU  - Chase JG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110831
PL  - Ireland
TA  - Comput Methods Programs Biomed
JT  - Computer methods and programs in biomedicine
JID - 8506513
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Blood Glucose/*analysis
MH  - *Clinical Protocols
MH  - *Critical Illness
MH  - Female
MH  - Humans
MH  - Male
MH  - Pilot Projects
MH  - Stochastic Processes
EDAT- 2011/09/03 06:00
MHDA- 2013/03/19 06:00
CRDT- 2011/09/03 06:00
PHST- 2011/02/08 00:00 [received]
PHST- 2011/06/17 00:00 [revised]
PHST- 2011/07/04 00:00 [accepted]
PHST- 2011/09/03 06:00 [entrez]
PHST- 2011/09/03 06:00 [pubmed]
PHST- 2013/03/19 06:00 [medline]
AID - S0169-2607(11)00191-X [pii]
AID - 10.1016/j.cmpb.2011.07.003 [doi]
PST - ppublish
SO  - Comput Methods Programs Biomed. 2012 Nov;108(2):844-59. doi:
      10.1016/j.cmpb.2011.07.003. Epub 2011 Aug 31.


PMID- 21885089
OWN - NLM
STAT- MEDLINE
DCOM- 20120312
LR  - 20191210
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 85
IP  - 10
DP  - 2011 Nov
TI  - Evaluation of the fish short term reproduction assay for detecting endocrine
      disrupters.
PG  - 1592-603
LID - 10.1016/j.chemosphere.2011.08.006 [doi]
AB  - In a fish testing strategy, positive results of the fish short term reproduction 
      assay (FSTR), often trigger a definitive test like the fish sexual development
      test (FSDT) or the fish full life cycle test (FFLC), entailing ethical and
      economic problems. This study analysed 137 studies encompassing 35 chemicals with
      different modes of actions (MOAs). Variability is quantified for MOA endpoints
      vitellogenin (VTG) and secondary sex characteristics (SSCs) as well as for apical
      endpoints. Two MOA endpoints could indicate estrogenic, anti-estrogenic,
      androgenic, anti-androgenic and steroidogenesis activities. Great variability,
      however, has been observed for chemicals with anti-androgenic and steroidogenesis
      activities, suggesting that TG229/230 may not be sensitive enough to detect these
      types of chemicals and may produce false negatives. Changes in apical endpoints
      like fecundity are not limited to endocrine disrupting chemicals (EDCs). Non-EDCs
      could induce the similar effects on these apical endpoints. If elucidating MOA is
      needed, targeted in vitro MOA tests are suggested. Positive in vitro MOA results 
      trigger a definitive test, which could be used for confirmation of the MOA in
      vivo and for deriving a no observed effect concentration (NOEC). Based on
      positive MOA results of TG229, a definitive test such as the FSDT or the FFLC is 
      still needed, because the current TG229 has limitation on the derivation of a
      NOEC. An extended TG229 with more power to detect reproduction effects, as
      recently proposed in the OECD test guideline program, would improve the
      possibility to derive a NOEC and increase its usefulness in risk assessment.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Dang, ZhiChao
AU  - Dang Z
AD  - National Institute for Public Health and the Environment, A. van Leeuwenhoeklaan 
      9, Bilthoven, The Netherlands. zhichao.dang@rivm.nl
FAU - Traas, Theo
AU  - Traas T
FAU - Vermeire, Theo
AU  - Vermeire T
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110831
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Vitellogenins)
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
MH  - Animals
MH  - Endocrine Disruptors/*analysis/toxicity
MH  - Fishes
MH  - Reproduction/*drug effects
MH  - Risk Assessment
MH  - Sexual Development/drug effects
MH  - Toxicity Tests
MH  - Vitellogenins/metabolism
MH  - Water Pollutants, Chemical/*analysis/toxicity
EDAT- 2011/09/03 06:00
MHDA- 2012/03/13 06:00
CRDT- 2011/09/03 06:00
PHST- 2011/05/11 00:00 [received]
PHST- 2011/07/29 00:00 [revised]
PHST- 2011/08/03 00:00 [accepted]
PHST- 2011/09/03 06:00 [entrez]
PHST- 2011/09/03 06:00 [pubmed]
PHST- 2012/03/13 06:00 [medline]
AID - S0045-6535(11)00953-2 [pii]
AID - 10.1016/j.chemosphere.2011.08.006 [doi]
PST - ppublish
SO  - Chemosphere. 2011 Nov;85(10):1592-603. doi: 10.1016/j.chemosphere.2011.08.006.
      Epub 2011 Aug 31.


PMID- 21884944
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20110902
IS  - 1558-3597 (Electronic)
IS  - 0735-1097 (Linking)
VI  - 58
IP  - 11
DP  - 2011 Sep 6
TI  - 10 years of intracoronary and intramyocardial bone marrow stem cell therapy of
      the heart: from the methodological origin to clinical practice.
PG  - 1095-104
LID - 10.1016/j.jacc.2011.06.016 [doi]
AB  - Intracoronary and intramyocardial stem cell therapy aim at the repair of
      compromised myocardium thereby--as a causal treatment--preventing ventricular
      remodeling and improving overall performance. Since the first-in-human use of
      bone marrow stem cells (BMCs) after acute myocardial infarction in 2001, a large 
      number of clinical studies have demonstrated their clinical benefit: BMC therapy 
      can be performed with usual cardiac catheterization techniques in the conscious
      patient as well as also easily during cardiosurgical interventions. New York
      Heart Association severity degree of patients as well as physical activity
      improve in addition to ("on top" of) all other therapeutic regimens. Stem cell
      therapy also represents an ultimate approach in advanced cardiac failure. For
      acute myocardial infarction and chronic ischemia, long-term mortality after 1 and
      5 years, respectively, is significantly reduced. A few studies also indicate
      beneficial effects for chronic dilated cardiomyopathy. The clinical use of
      autologous BMC therapy implies no ethical problems, when unmodified primary cells
      are used. With the use of primary BMCs, there are no major stem cell-related side
      effects, especially no cardiac arrhythmias and inflammation. Various mechanisms
      of the stem cell action in the human heart are discussed, for example, cell
      transdifferentiation, cell fusion, activation of intrinsic cardiac stem cells,
      and cytokine-mediated effects. New techniques allow point-of-care cell
      preparations, for example, within the cardiac intervention or operation theater, 
      thereby providing short preparation time, facilitated logistics of cell
      transport, and reasonable cost effectiveness of the whole procedure. The 3 main
      indications are acute infarction, chronic ischemic heart failure, and dilated
      cardiomyopathy. Future studies are desirable to further elucidate the mechanisms 
      of stem cell action and to extend the current use of intracoronary and/or
      intramyocardial stem cell therapy by larger and presumably multicenter and
      randomized trials.
CI  - Copyright (c) 2011 American College of Cardiology Foundation. Published by
      Elsevier Inc. All rights reserved.
FAU - Strauer, Bodo-Eckehard
AU  - Strauer BE
AD  - Heinrich-Heine University of Duesseldorf, Duesseldorf, Germany.
FAU - Steinhoff, Gustav
AU  - Steinhoff G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - J Am Coll Cardiol
JT  - Journal of the American College of Cardiology
JID - 8301365
SB  - IM
MH  - *Bone Marrow Transplantation
MH  - Cardiac Surgical Procedures
MH  - Cardiomyopathy, Dilated/*therapy
MH  - Clinical Trials as Topic
MH  - Endovascular Procedures
MH  - Humans
MH  - Myocardial Infarction/*therapy
MH  - *Stem Cell Transplantation
EDAT- 2011/09/03 06:00
MHDA- 2011/10/25 06:00
CRDT- 2011/09/03 06:00
PHST- 2011/03/04 00:00 [received]
PHST- 2011/04/06 00:00 [revised]
PHST- 2011/04/07 00:00 [accepted]
PHST- 2011/09/03 06:00 [entrez]
PHST- 2011/09/03 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
AID - S0735-1097(11)02285-6 [pii]
AID - 10.1016/j.jacc.2011.06.016 [doi]
PST - ppublish
SO  - J Am Coll Cardiol. 2011 Sep 6;58(11):1095-104. doi: 10.1016/j.jacc.2011.06.016.


PMID- 21884634
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 2043-9113 (Electronic)
IS  - 2043-9113 (Linking)
VI  - 1
IP  - 1
DP  - 2011 Jul 6
TI  - Discovering and validating unknown phospho-sites from p38 and HuR protein kinases
      in vitro by Phosphoproteomic and Bioinformatic tools.
PG  - 16
LID - 10.1186/2043-9113-1-16 [doi]
AB  - BACKGROUND: The mitogen activated protein kinase (MAPK) pathways are known to be 
      deregulated in many human malignancies. Phosphopeptide identification of
      protein-kinases and site determination are major challenges in biomedical mass
      spectrometry (MS). P38 and HuR protein kinases have been reported extensively in 
      the general principles of signalling pathways modulated by phosphorylation,
      mainly by molecular biology and western blotting techniques. Thus, although it
      has been demonstrated they are phosphorylated in different stress/stimuli
      conditions, the phosphopeptides and specific amino acids in which the phosphate
      groups are located in those protein kinases have not been shown completely.
      METHODS: We have combined different resins: (a) IMAC (Immobilized Metal Affinity 
      Capture), (b) TiO2 (Titanium dioxide) and (c) SIMAC (Sequential Elution from
      IMAC) to isolate phosphopeptides from p38 and HuR protein kinases in
      vitro.Different phosphopeptide MS strategies were carried out by the LTQ ion Trap
      mass spectrometer (Thermo): (a) Multistage activation (MSA) and (b) Neutral loss 
      MS3 (DDNLMS3).In addition, Molecular Dynamics (MD) bioinformatic simulation has
      been applied in order to simulate, over a period of time, the effects of the
      presence of the extra phosphate group (and the associated negative charge) in the
      overall structure and behaviour of the protein HuR.This study is supported by the
      Declaration of Helsinki and subsequent ethical guidelines. RESULTS: The
      combination of these techniques allowed for:(1) The identification of 6 unknown
      phosphopeptides of these protein kinases. (2) Amino acid site assignments of the 
      phosphate groups from each identified phosphopeptide, including manual validation
      by inspection of all the spectra. (3) The analyses of the phosphopeptides
      discovered were carried out in four triplicate experiments to avoid false
      positives getting high reproducibility in all the isolated phosphopeptides
      recovered from both protein kinases. (4) Computer simulation using MD techniques 
      allowed us to get functional models of both structure and interactions of the
      previously mentioned phosphorylated kinases and the differences between their
      phosphorylated and un-phosphorylated forms. CONCLUSION: Many research studies are
      necessary to unfold the whole signalling network (human proteome), which is so
      important to advance in clinical research, especially in the cases of malignant
      diseases.
FAU - Lopez, Elena
AU  - Lopez E
AD  - Phosphoproteomic core, Spanish National Cancer Research Centre (CNIO), C/Melchor 
      Fernandez Almagro, 3, 28029, Madrid, Spain. elena.lopez.villar@gmail.com.
FAU - Lopez, Isabel
AU  - Lopez I
FAU - Sequi, Julia
AU  - Sequi J
FAU - Ferreira, Antonio
AU  - Ferreira A
LA  - eng
PT  - Journal Article
DEP - 20110706
PL  - England
TA  - J Clin Bioinforma
JT  - Journal of clinical bioinformatics
JID - 101554637
PMC - PMC3164609
EDAT- 2011/09/03 06:00
MHDA- 2011/09/03 06:01
CRDT- 2011/09/03 06:00
PHST- 2011/04/20 00:00 [received]
PHST- 2011/07/06 00:00 [accepted]
PHST- 2011/09/03 06:00 [entrez]
PHST- 2011/09/03 06:00 [pubmed]
PHST- 2011/09/03 06:01 [medline]
AID - 2043-9113-1-16 [pii]
AID - 10.1186/2043-9113-1-16 [doi]
PST - epublish
SO  - J Clin Bioinforma. 2011 Jul 6;1(1):16. doi: 10.1186/2043-9113-1-16.


PMID- 21884556
OWN - NLM
STAT- MEDLINE
DCOM- 20120306
LR  - 20220409
IS  - 1365-2702 (Electronic)
IS  - 0962-1067 (Linking)
VI  - 20
IP  - 23-24
DP  - 2011 Dec
TI  - Moral distress and ethical climate in a Swedish nursing context: perceptions and 
      instrument usability.
PG  - 3483-93
LID - 10.1111/j.1365-2702.2011.03753.x [doi]
AB  - AIMS AND OBJECTIVES: The aim was fivefold: to describe Swedish nurses'
      perceptions of moral distress and determine whether there were differences in
      perceptions depending on demographic characteristics and to describe the
      usability of the Moral Distress Scale in a Swedish context. Further, the aim was 
      to describe Swedish nurses' perceptions of ethical climate and the relationship
      between moral distress and ethical climate. BACKGROUND: Moral distress has been
      studied for more than two decades and the Moral Distress Scale is the most widely
      used instrument for measuring it. Moral distress has mainly been studied in
      relation to nurses' characteristics, but increasing attention has been paid to
      contextual aspects, such as ethical climate, that could be associated with moral 
      distress. DESIGN: Descriptive, with a quantitative approach. METHODS: The study
      used two questionnaires: the Moral Distress Scale and the Hospital Ethical
      Climate Survey. The study was carried out at two hospitals in Sweden and included
      249 nurses. RESULTS: Both level and frequency of moral distress were low, however
      level of moral distress was high in situations when the patient was not given
      safe and proper care. Generally, the frequency of moral distress was lower than
      the level. Of the situations on the Moral Distress Scale, 13 of the 32 were
      considered irrelevant by 10-50% of the participants. The more positive the
      ethical climate was perceived to be, the less frequently morally distressing
      situations were reported. CONCLUSIONS: Since a positive ethical climate was
      associated with less frequent occurrences of moral distress, it should be
      investigated what contributes to a positive ethical climate. To be used in a
      Swedish context, the Moral Distress Scale needs further revision. RELEVANCE TO
      CLINICAL PRACTICE: Open dialogues at wards are encouraged regarding what
      practices contribute to a positive ethical climate.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Silen, Marit
AU  - Silen M
AD  - School of Health Sciences, Jonkoping, Sweden. marit.silen@hhj.hj.se
FAU - Svantesson, Mia
AU  - Svantesson M
FAU - Kjellstrom, Sofia
AU  - Kjellstrom S
FAU - Sidenvall, Birgitta
AU  - Sidenvall B
FAU - Christensson, Lennart
AU  - Christensson L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110902
PL  - England
TA  - J Clin Nurs
JT  - Journal of clinical nursing
JID - 9207302
MH  - *Morale
MH  - *Nursing
MH  - *Stress, Psychological
MH  - Sweden
EDAT- 2011/09/03 06:00
MHDA- 2012/03/07 06:00
CRDT- 2011/09/03 06:00
PHST- 2011/09/03 06:00 [entrez]
PHST- 2011/09/03 06:00 [pubmed]
PHST- 2012/03/07 06:00 [medline]
AID - 10.1111/j.1365-2702.2011.03753.x [doi]
PST - ppublish
SO  - J Clin Nurs. 2011 Dec;20(23-24):3483-93. doi: 10.1111/j.1365-2702.2011.03753.x.
      Epub 2011 Sep 2.


PMID- 21884516
OWN - NLM
STAT- MEDLINE
DCOM- 20111222
LR  - 20211203
IS  - 1752-8062 (Electronic)
IS  - 1752-8054 (Linking)
VI  - 4
IP  - 4
DP  - 2011 Aug
TI  - Translating gene transfer: a stalled effort.
PG  - 279-81
LID - 10.1111/j.1752-8062.2011.00297.x [doi]
AB  - The journey of gene transfer from laboratory to clinic has been slow and fraught 
      with many challenges and barriers. Despite the development of the initial
      technology in the early 1970s, a standard clinical treatment involving "gene
      therapy" remains to be seen. Furthermore, much was written about the technology
      in the early 1990s, but since then, not much has been written about the journey
      of gene transfer. The translational path of gene transfer thus far, both pitfalls
      and successes, can serve as a study not only in navigating ethical and safety
      concerns, but also in the importance of scientist-public interactions. Here, we
      examine the translational progress of gene transfer and what can be gleaned from 
      its history.
CI  - (c) 2011 Wiley Periodicals, Inc.
FAU - Greenberg, Alexandra J
AU  - Greenberg AJ
AD  - Mayo Clinic College of Medicine, Center for Translational Science Activities,
      Rochester, Minnesota, USA. greenberg.alexandra@mayo.edu
FAU - McCormick, Jennifer
AU  - McCormick J
FAU - Tapia, Carmen J
AU  - Tapia CJ
FAU - Windebank, Anthony J
AU  - Windebank AJ
LA  - eng
GR  - TL1 RR024152/RR/NCRR NIH HHS/United States
GR  - TL1 RR024152-01/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United States
TA  - Clin Transl Sci
JT  - Clinical and translational science
JID - 101474067
SB  - IM
MH  - Clinical Trials as Topic
MH  - *Genetic Therapy/adverse effects
MH  - HIV Infections/therapy
MH  - Humans
MH  - *Translational Research, Biomedical
PMC - PMC3170101
MID - NIHMS309464
EDAT- 2011/09/03 06:00
MHDA- 2011/12/23 06:00
CRDT- 2011/09/03 06:00
PHST- 2011/09/03 06:00 [entrez]
PHST- 2011/09/03 06:00 [pubmed]
PHST- 2011/12/23 06:00 [medline]
AID - 10.1111/j.1752-8062.2011.00297.x [doi]
PST - ppublish
SO  - Clin Transl Sci. 2011 Aug;4(4):279-81. doi: 10.1111/j.1752-8062.2011.00297.x.


PMID- 21884398
OWN - NLM
STAT- MEDLINE
DCOM- 20111229
LR  - 20110902
IS  - 1939-3938 (Electronic)
IS  - 1556-3693 (Linking)
VI  - 7
IP  - 3
DP  - 2011 Sep
TI  - Walking a fine line: Forensic mental health practitioners' experience of working 
      with correctional officers.
PG  - 109-19
LID - 10.1111/j.1939-3938.2011.01107.x [doi]
AB  - This paper explores mental health professionals' experiences working with
      correctional staff--one aspect of an interdisciplinary phenomenological study of 
      ethical practice in forensic psychiatry. Professionals describe this relationship
      as coexisting within the system, despite their often conflicting roles. In
      correctional officers' overt concern for custody and control, practitioners can
      perceive a "paramilitary mentality" with which they struggle to work. Conversely,
      practitioners can experience conflict with security personnel for appearing "too 
      caring" or "too sympathetic" to offenders--being "con-lovers." The balance
      practitioners establish between working with inmates and working alongside
      facility security is one of walking a fine line.
CI  - (c) 2011 International Association of Forensic Nurses.
FAU - Lazzaretto-Green, Danille
AU  - Lazzaretto-Green D
AD  - Faculty of Education, University of Lethbridge, Alberta, Canada.
FAU - Austin, Wendy
AU  - Austin W
FAU - Goble, Erika
AU  - Goble E
FAU - Buys, Lisa
AU  - Buys L
FAU - Gorman, Tom
AU  - Gorman T
FAU - Rankel, Marlene
AU  - Rankel M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Forensic Nurs
JT  - Journal of forensic nursing
JID - 101234500
SB  - IM
MH  - *Forensic Psychiatry
MH  - Humans
MH  - Interprofessional Relations
MH  - Interviews as Topic
MH  - Mental Disorders/*therapy
MH  - Nurses
MH  - *Police
MH  - *Prisons
MH  - Professional Autonomy
MH  - *Professional Role
MH  - Psychiatry
MH  - Psychology
MH  - Social Work
EDAT- 2011/09/03 06:00
MHDA- 2011/12/30 06:00
CRDT- 2011/09/03 06:00
PHST- 2011/09/03 06:00 [entrez]
PHST- 2011/09/03 06:00 [pubmed]
PHST- 2011/12/30 06:00 [medline]
AID - 10.1111/j.1939-3938.2011.01107.x [doi]
PST - ppublish
SO  - J Forensic Nurs. 2011 Sep;7(3):109-19. doi: 10.1111/j.1939-3938.2011.01107.x.


PMID- 21883769
OWN - NLM
STAT- MEDLINE
DCOM- 20120404
LR  - 20220311
IS  - 1442-2018 (Electronic)
IS  - 1441-0745 (Linking)
VI  - 13
IP  - 4
DP  - 2011 Dec
TI  - Development of the Holistic Nursing Competence Scale.
PG  - 396-403
LID - 10.1111/j.1442-2018.2011.00631.x [doi]
AB  - This study developed a scale to measure the nursing competence of Japanese
      registered nurses and to test its psychometric properties. Following the
      derivation of scale items and pilot testing, the final version of the scale was
      administered to 331 nurses to establish its internal consistency, as well as its 
      construct and criterion-related validity. Using an exploratory and a confirmatory
      factor analysis, 36 items with a five-factor structure were retained to form the 
      Holistic Nursing Competence Scale. These factors illustrate nurses' general
      aptitude and their competencies in staff education and management, ethical
      practice, the provision of nursing care, and professional development. The Scale 
      has a positive correlation with the length of clinical experience. A Cronbach's
      alpha coefficient was 0.967. The Scale is a reliable and valid measure, helping
      both nurses and organizations to correctly evaluate nurses' competence and
      identify their needs for professional development.
CI  - (c) 2011 Blackwell Publishing Asia Pty Ltd.
FAU - Takase, Miyuki
AU  - Takase M
AD  - School of Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku,
      Hiroshima, Japan. mtakase@hiroshima-u.ac.jp
FAU - Teraoka, Sachiko
AU  - Teraoka S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110831
PL  - Australia
TA  - Nurs Health Sci
JT  - Nursing & health sciences
JID - 100891857
SB  - IM
MH  - Adult
MH  - Chi-Square Distribution
MH  - Clinical Competence/*standards/statistics & numerical data
MH  - Cross-Sectional Studies
MH  - Factor Analysis, Statistical
MH  - Female
MH  - Health Surveys
MH  - Holistic Nursing/*standards/statistics & numerical data
MH  - Humans
MH  - Internationality
MH  - Japan
MH  - Male
MH  - Pilot Projects
MH  - Psychometrics/*methods/standards
MH  - Reproducibility of Results
MH  - Self-Assessment
MH  - Staff Development/methods/*standards
EDAT- 2011/09/03 06:00
MHDA- 2012/04/05 06:00
CRDT- 2011/09/03 06:00
PHST- 2011/09/03 06:00 [entrez]
PHST- 2011/09/03 06:00 [pubmed]
PHST- 2012/04/05 06:00 [medline]
AID - 10.1111/j.1442-2018.2011.00631.x [doi]
PST - ppublish
SO  - Nurs Health Sci. 2011 Dec;13(4):396-403. doi: 10.1111/j.1442-2018.2011.00631.x.
      Epub 2011 Aug 31.


PMID- 21883572
OWN - NLM
STAT- MEDLINE
DCOM- 20120409
LR  - 20111214
IS  - 1365-2702 (Electronic)
IS  - 0962-1067 (Linking)
VI  - 21
IP  - 1-2
DP  - 2012 Jan
TI  - Fathers of children with disabilities: encounters with health professionals in a 
      Chinese context.
PG  - 198-206
LID - 10.1111/j.1365-2702.2011.03826.x [doi]
AB  - AIMS: The aim of this study was to examine the experiences of fathers of
      developmentally disabled children during interactions with health professionals
      in Taiwan. BACKGROUND: The role of Chinese fathers in raising a disabled child
      has been neglected because most studies on the impact of parenting a child with
      disabilities in this culture have primarily focused on mothers. DESIGN: A
      hermeneutic phenomenological approach was undertaken to recover and interpret
      fathers' experiences. METHOD: Sixteen fathers living with their disabled child
      (0-18 years old) were purposively recruited from a teaching hospital in central
      Taiwan. Data were collected using in-depth interviews and journal notes. All
      participants were interviewed twice. Interviews lasted from 50-100 minutes, and
      all were recorded. RESULTS: Three shared meanings were attributed to fathers'
      interactions with health professionals: (1) experiencing no supportive
      communication, (2) missing the critical time for disability management and (3)
      being excluded from medical decision making. CONCLUSIONS: Fathers in Taiwan
      commonly rely on health professionals to solve their child's health problems
      owing to their perceived power to cure and their professional authority in
      Chinese society. However, fathers felt powerless and hopeless when they received 
      unclear information and incorrect diagnoses, which delayed appropriate treatment.
      Expressions of dissatisfaction and possessing a sense of futility were common
      experiences related to exclusion in a paternalistic healthcare system. RELEVANCE 
      TO CLINICAL PRACTICE: Taiwanese clinicians' attitudes and parental-professional
      relationships challenge an exploration of ethics and standards of medical care
      shaped by Chinese culture. Ways of promoting parental inclusion in decision
      making and care, in particular father's inclusion, need to be explored.
      Recognition of the Chinese mother and father and their differing parental
      healthcare experiences are important to understand to ensure improvement in
      encounters with health professionals and the maximisation of positive health
      outcomes.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Huang, Yu-Ping
AU  - Huang YP
AD  - Department of Nursing, HungKuang University, Taichung, Taiwan.
      yup@sunrise.hk.edu.tw
FAU - Tsai, Sen-Wei
AU  - Tsai SW
FAU - Kellett, Ursula
AU  - Kellett U
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110826
PL  - England
TA  - J Clin Nurs
JT  - Journal of clinical nursing
JID - 9207302
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Decision Making
MH  - *Disabled Children
MH  - Fathers/*psychology
MH  - *Health Personnel
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Middle Aged
MH  - *Professional-Family Relations
MH  - Taiwan
EDAT- 2011/09/03 06:00
MHDA- 2012/04/10 06:00
CRDT- 2011/09/03 06:00
PHST- 2011/09/03 06:00 [entrez]
PHST- 2011/09/03 06:00 [pubmed]
PHST- 2012/04/10 06:00 [medline]
AID - 10.1111/j.1365-2702.2011.03826.x [doi]
PST - ppublish
SO  - J Clin Nurs. 2012 Jan;21(1-2):198-206. doi: 10.1111/j.1365-2702.2011.03826.x.
      Epub 2011 Aug 26.


PMID- 21883341
OWN - NLM
STAT- MEDLINE
DCOM- 20120719
LR  - 20181201
IS  - 1471-6712 (Electronic)
IS  - 0283-9318 (Linking)
VI  - 26
IP  - 1
DP  - 2012 Mar
TI  - Organizational differences in early child health care -- mothers' and nurses'
      experiences of the services.
PG  - 161-8
LID - 10.1111/j.1471-6712.2011.00910.x [doi]
AB  - AIM: The aim of this study was to evaluate parents' and nurses' perceptions of
      the child health services (CHS) in relation to whether the nurse worked
      exclusively with children (focused-child health centre, CHC) vs. with people of
      all ages (mixed-CHC). METHOD: Information about parents' perceptions about the
      CHS was acquired by a questionnaire intended for the mothers of 18-month-old
      children. One thousand thirty-nine answered in the baseline 2002-2003 and 996 in 
      the follow-up 2004-2005. The nurses answered a special questionnaire aimed to
      obtain knowledge about their satisfaction with their work. Eighteen CHCs were
      chosen from the county of Uppsala and eighteen from other Swedish counties. The
      CHCs were chosen from areas with poor psycho-social status. The data were
      collected by questionnaires to mothers and nurses, and the analysis used the
      chi-square test, t-test and logistic regression. The study was approved by the
      Research Ethics Committees of the universities involved. RESULTS: Mothers were
      more satisfied, and the nurses found their work tasks easier, at CHCs where the
      child health nurse worked exclusively with children, compared with mothers and
      nurses belonging to CHCs where the nurses provided care to people of all ages.
      CONCLUSION: The findings indicated that nurses working exclusively with children,
      being able to concentrate their time and knowledge on a specialized field,
      develop a more solid child health competence. There are strong reasons to
      consider introducing 'exclusive' CHCs in psycho-socially vulnerable areas, which 
      would probably make the services more effective. However, intensified education
      may modify the drawbacks of mixed-CHCs.
CI  - (c) 2011 The Authors. Scandinavian Journal of Caring Sciences (c) 2011 Nordic
      College of Caring Science.
FAU - Magnusson, Margaretha
AU  - Magnusson M
AD  - Department of Women's and Children's Health, Section for Paediatrics, Uppsala
      University, Children's Hospital, Uppsala, Sweden. margaretha.magnusson@kbh.uu.se
FAU - Lagerberg, Dagmar
AU  - Lagerberg D
FAU - Sundelin, Claes
AU  - Sundelin C
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
DEP - 20110902
PL  - Sweden
TA  - Scand J Caring Sci
JT  - Scandinavian journal of caring sciences
JID - 8804206
MH  - *Attitude to Health
MH  - Child Health Services/*organization & administration
MH  - Community Health Nursing/*organization & administration
MH  - Cross-Sectional Studies
MH  - Humans
MH  - Infant
MH  - *Job Satisfaction
MH  - Logistic Models
MH  - Models, Organizational
MH  - Pediatric Nursing/education
MH  - Sweden
MH  - Workforce
EDAT- 2011/09/03 06:00
MHDA- 2012/07/20 06:00
CRDT- 2011/09/03 06:00
PHST- 2011/09/03 06:00 [entrez]
PHST- 2011/09/03 06:00 [pubmed]
PHST- 2012/07/20 06:00 [medline]
AID - 10.1111/j.1471-6712.2011.00910.x [doi]
PST - ppublish
SO  - Scand J Caring Sci. 2012 Mar;26(1):161-8. doi: 10.1111/j.1471-6712.2011.00910.x. 
      Epub 2011 Sep 2.


PMID- 21882937
OWN - NLM
STAT- MEDLINE
DCOM- 20111223
LR  - 20110902
IS  - 1756-8927 (Electronic)
IS  - 1756-8919 (Linking)
VI  - 3
IP  - 12
DP  - 2011 Sep
TI  - Ethical issues related to clinical trials outside the International Conference on
      Harmonization regions.
PG  - 1457-60
LID - 10.4155/fmc.11.111 [doi]
FAU - Karbwang, Juntra
AU  - Karbwang J
FAU - Torres, Cristina
AU  - Torres C
LA  - eng
PT  - Editorial
PL  - England
TA  - Future Med Chem
JT  - Future medicinal chemistry
JID - 101511162
SB  - IM
MH  - Clinical Trials as Topic/*ethics/standards
MH  - Ethics Committees, Clinical/standards
MH  - Humans
MH  - Research Design/standards
MH  - Risk Assessment
EDAT- 2011/09/03 06:00
MHDA- 2011/12/24 06:00
CRDT- 2011/09/03 06:00
PHST- 2011/09/03 06:00 [entrez]
PHST- 2011/09/03 06:00 [pubmed]
PHST- 2011/12/24 06:00 [medline]
AID - 10.4155/fmc.11.111 [doi]
PST - ppublish
SO  - Future Med Chem. 2011 Sep;3(12):1457-60. doi: 10.4155/fmc.11.111.


PMID- 21882901
OWN - NLM
STAT- MEDLINE
DCOM- 20120223
LR  - 20111018
IS  - 1557-7740 (Electronic)
IS  - 1557-7740 (Linking)
VI  - 14
IP  - 10
DP  - 2011 Oct
TI  - Is pacemaker deactivation at the end of life unique? A case study and ethical
      analysis.
PG  - 1184-8
LID - 10.1089/jpm.2011.0084 [doi]
AB  - Although there has been considerable controversy regarding the deactivation of
      pacemakers near the end of life, clinicians can expect to face more requests for 
      pacemaker withdrawal as the number of implants grows. Despite a clear ethical and
      legal precedent, these requests may elicit significant psychological and moral
      distress on the part of the clinical team. We illustrate some of the difficulties
      clinicians may face by describing the case of a patient with end-stage heart
      failure who asked to have her pacemaker turned off near the end of life. We
      discuss the challenges in determining pacemaker dependency, differing attitudes
      toward deactivating pacemakers versus other cardiac devices, and how the issues
      of perceived burden and timing of death may contribute to a clinician's sense of 
      moral distress.
FAU - Whitlock, Sandra N
AU  - Whitlock SN
AD  - Four Seasons, Flat Rock, North Carolina 28731, USA. swhitlock@fourseasonscfl.org
FAU - Goldberg, Ilan P
AU  - Goldberg IP
FAU - Singh, Jagmeet P
AU  - Singh JP
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20110901
PL  - United States
TA  - J Palliat Med
JT  - Journal of palliative medicine
JID - 9808462
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Defibrillators, Implantable/ethics
MH  - *Ethics, Medical
MH  - Euthanasia, Passive/*ethics
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Terminal Care/*ethics
MH  - Time Factors
EDAT- 2011/09/03 06:00
MHDA- 2012/02/24 06:00
CRDT- 2011/09/03 06:00
PHST- 2011/09/03 06:00 [entrez]
PHST- 2011/09/03 06:00 [pubmed]
PHST- 2012/02/24 06:00 [medline]
AID - 10.1089/jpm.2011.0084 [doi]
PST - ppublish
SO  - J Palliat Med. 2011 Oct;14(10):1184-8. doi: 10.1089/jpm.2011.0084. Epub 2011 Sep 
      1.


PMID- 21882116
OWN - NLM
STAT- MEDLINE
DCOM- 20120227
LR  - 20110901
IS  - 0171-2004 (Print)
IS  - 0171-2004 (Linking)
VI  - 205
DP  - 2011
TI  - Fetal medicine and treatment.
PG  - 271-83
LID - 10.1007/978-3-642-20195-0_13 [doi]
AB  - Fetal medicine covers a broad spectrum of conditions that can be diagnosed before
      birth. Different disorders will require different treatment strategies and there 
      is often an important ontogenetic aspect on how and when treatment can be
      implemented. Due to the limited availability there is a general lack of knowledge
      on how pharmacotherapy can be provided in the most efficient way. Until recently 
      most knowledge about how different drugs are transferred and metabolized in the
      human fetus is based on very limited observational studies on concentrations of
      drugs in fetal blood and other fetal compartments. It might be that the rapid
      development of other non-invasive methods for fetal diagnostics such as isolation
      of fetal DNA and RNA in maternal serum, NMR imaging and other techniques could in
      the future be explored in fetal pharmacotherapy. Introduction of new treatment
      strategies are often based on extrapolation from experience in neonates and
      adults. However some fetal conditions are very specific for this time period in
      life. This especially entails disturbances in development as malformations, early
      growth restriction and several congenital disorders. Here it might be required to
      introduce new treatment strategies without any previous experience in humans.
      Example of this ethical dilemma is gene therapy for lung growth in severe cases
      of diaphragmatic hernia and early growth restriction. The risk-benefit issues
      need to be discussed in all these alternatives. However, it is likely that the
      concept of the human fetus as a potential patient is still in its infancy and
      with an improved understanding about fetal patho-physiology there will be a
      continued need for better knowledge of pharmacotherapy during this crucial time
      period in life.
FAU - Westgren, Magnus
AU  - Westgren M
AD  - Division of Obstetrics and Gynecology, Department of Clinical Science,
      Intervention and Technology Centre for Fetal Medicine, Karolinska University
      Hospital, Karolinska Institutet, S-141 86 Stockholm, Sweden.
      magnus.westgren@ki.se
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Handb Exp Pharmacol
JT  - Handbook of experimental pharmacology
JID - 7902231
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Analgesics)
RN  - 0 (Anti-Arrhythmia Agents)
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Adrenal Cortex Hormones/therapeutic use
MH  - Analgesics/administration & dosage/therapeutic use
MH  - Anemia/therapy
MH  - Anti-Arrhythmia Agents/administration & dosage/therapeutic use
MH  - Arrhythmias, Cardiac/drug therapy
MH  - Blood Transfusion, Intrauterine/methods
MH  - Cytomegalovirus Infections/drug therapy
MH  - Female
MH  - Fetal Diseases/drug therapy/*therapy
MH  - Fetal Therapies/*methods
MH  - Goiter/drug therapy
MH  - Humans
MH  - Infant, Newborn
MH  - Maternal-Fetal Exchange/physiology
MH  - Pharmaceutical Preparations/administration & dosage/metabolism
MH  - Pharmacokinetics
MH  - Placenta/metabolism
MH  - Pregnancy
MH  - Respiratory Distress Syndrome, Newborn/prevention & control
MH  - Stem Cell Transplantation/methods
EDAT- 2011/09/02 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/09/02 06:00
PHST- 2011/09/02 06:00 [entrez]
PHST- 2011/09/02 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - 10.1007/978-3-642-20195-0_13 [doi]
PST - ppublish
SO  - Handb Exp Pharmacol. 2011;205:271-83. doi: 10.1007/978-3-642-20195-0_13.


PMID- 21882114
OWN - NLM
STAT- MEDLINE
DCOM- 20120227
LR  - 20110901
IS  - 0171-2004 (Print)
IS  - 0171-2004 (Linking)
VI  - 205
DP  - 2011
TI  - Ethical considerations in conducting pediatric research.
PG  - 219-44
LID - 10.1007/978-3-642-20195-0_11 [doi]
AB  - The critical need for pediatric research on drugs and biological products
      underscores the responsibility to ensure that children are enrolled in clinical
      research that is both scientifically necessary and ethically sound. In this
      chapter, we review key ethical considerations concerning the participation of
      children in clinical research. We propose a basic ethical framework to guide
      pediatric research, and suggest how this framework might be operationalized in
      linking science and ethics. Topics examined include: the status of children as a 
      vulnerable population; the appropriate balance of risk and potential benefit in
      research; ethical considerations underlying study design, including clinical
      equipoise, placebo controls, and non-inferiority designs; the use of data
      monitoring committees; compensation; and parental permission and child assent to 
      participate in research. We incorporate selected national (USA) and international
      guidelines, as well as regulatory approaches to pediatric studies that have been 
      adopted in the USA, Canada, and Europe.
FAU - Roth-Cline, Michelle
AU  - Roth-Cline M
AD  - U.S. Department of Health and Human Services, Food and Drug Administration,
      Office of the Commissioner, Office of Pediatric Therapeutics, Silver Spring, MD
      2011, USA.
FAU - Gerson, Jason
AU  - Gerson J
FAU - Bright, Patricia
AU  - Bright P
FAU - Lee, Catherine S
AU  - Lee CS
FAU - Nelson, Robert M
AU  - Nelson RM
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Handb Exp Pharmacol
JT  - Handbook of experimental pharmacology
JID - 7902231
RN  - 0 (Placebos)
SB  - IM
MH  - Algorithms
MH  - Canada
MH  - Clinical Trials Data Monitoring Committees/legislation & jurisprudence
MH  - Clinical Trials as Topic/*ethics/legislation & jurisprudence/standards
MH  - Clinical Trials, Phase I as Topic/ethics/standards
MH  - Compensation and Redress/ethics
MH  - Controlled Clinical Trials as Topic/ethics/legislation & jurisprudence/standards
MH  - *Epidemiologic Research Design
MH  - Europe
MH  - Humans
MH  - Informed Consent By Minors/legislation & jurisprudence
MH  - Parental Consent/legislation & jurisprudence
MH  - Pediatrics/*ethics
MH  - Placebos
MH  - Risk Assessment/methods
MH  - Therapeutic Equipoise
MH  - United States
MH  - United States Food and Drug Administration
EDAT- 2011/09/02 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/09/02 06:00
PHST- 2011/09/02 06:00 [entrez]
PHST- 2011/09/02 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - 10.1007/978-3-642-20195-0_11 [doi]
PST - ppublish
SO  - Handb Exp Pharmacol. 2011;205:219-44. doi: 10.1007/978-3-642-20195-0_11.


PMID- 21882112
OWN - NLM
STAT- MEDLINE
DCOM- 20120227
LR  - 20110901
IS  - 0171-2004 (Print)
IS  - 0171-2004 (Linking)
VI  - 205
DP  - 2011
TI  - Small sample approach, and statistical and epidemiological aspects.
PG  - 181-202
LID - 10.1007/978-3-642-20195-0_9 [doi]
AB  - In this chapter, the design of pharmacokinetic studies and phase III trials in
      children is discussed. Classical approaches and relatively novel approaches,
      which may be more useful in the context of drug research in children, are
      discussed. The burden of repeated blood sampling in pediatric pharmacokinetic
      studies may be overcome by the population pharmacokinetics approach using
      nonlinear mixed effect modeling as the statistical solution to sparse data.
      Indications and contraindications for phase III trials are discussed: only when
      there is true "equipoise" in the medical scientific community, it is ethical to
      conduct a randomized clinical trial. The many reasons why a pediatric trial may
      fail are illustrated with examples. Inadequate sample sizes lead to inconclusive 
      results. Twelve classical strategies to minimize sample sizes are discussed
      followed by an introduction to group sequential design, boundaries design, and
      adaptive design. The evidence that these designs reduce sample sized between 35
      and 70% is reviewed. The advantages and disadvantages of the different approaches
      are highlighted to give the reader a broad idea of the design types that can be
      considered. Finally, working with DMCs during the conduct of trials is
      introduced. The evidence regarding DMC activities, interim analysis results, and 
      early termination of pediatric trials is presented. So far reporting is
      incomplete and heterogeneous, and users of trial reports may be misled by the
      results. A proposal for a checklist for the reporting of DMC issues, interim
      analyses, and early stopping is presented.
FAU - Offringa, Martin
AU  - Offringa M
AD  - Department of Paediatric Clinical Epidemiology, Emma Children's Hospital,
      Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ
      Amsterdam, The Netherlands. m.offringa@amc.uva.nl
FAU - van der Lee, Hanneke
AU  - van der Lee H
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Handb Exp Pharmacol
JT  - Handbook of experimental pharmacology
JID - 7902231
SB  - IM
MH  - Algorithms
MH  - Clinical Trials Data Monitoring Committees/standards
MH  - Clinical Trials as Topic/ethics/*methods/statistics & numerical data
MH  - Clinical Trials, Phase III as Topic/ethics/methods/statistics & numerical data
MH  - *Epidemiologic Research Design
MH  - Humans
MH  - Pediatrics/*methods
MH  - Pharmacokinetics
MH  - Sample Size
EDAT- 2011/09/02 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/09/02 06:00
PHST- 2011/09/02 06:00 [entrez]
PHST- 2011/09/02 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - 10.1007/978-3-642-20195-0_9 [doi]
PST - ppublish
SO  - Handb Exp Pharmacol. 2011;205:181-202. doi: 10.1007/978-3-642-20195-0_9.


PMID- 21881375
OWN - NLM
STAT- MEDLINE
DCOM- 20120217
LR  - 20190608
IS  - 2186-1005 (Electronic)
IS  - 1341-1098 (Linking)
VI  - 17
IP  - 5
DP  - 2011
TI  - Training in robotic surgery using the da Vinci(R) surgical system for left
      pneumonectomy and lymph node dissection in an animal model.
PG  - 446-53
AB  - OBJECTIVES: In Japan, as of March 2010, only 13 hospitals were using the da
      Vinci(R) system and only for selected cases. Few clinical robotic lung surgery
      has been done in Japan, and there are no standardized training programs, although
      some exist in the U.S. and are under consideration by the Japanese society for
      thoracic surgery. We have used the da Vinci S(R) Surgical System for
      pneumonectomy and lymph node dissection in pigs. We report and review future
      possibilities and problems of robotic surgery, especially concerning education,
      training, safety management and ethical considerations for pneumonectomy and
      lymph node dissection in clinical practice. METHODS: The da Vinci(R) system
      consists of a surgeon's console connected to a patient-side cart, a manipulator
      unit with three instrument arms and a central arm to guide the endoscope. The
      surgeon, sitting at the console, triggers highly sensitive motion sensors that
      transmit the surgeon's movements to the instrument arm. RESULTS: We experienced
      exactly the same sensation as when performing standard open thoracotomy. Visual
      recognition is 3-D, and the high manipulation potential allows free movement of
      the various accessory instruments, exceeding the capacity of a surgeon's hands in
      video-assisted thoracic surgery (VATS) or even standard thoracotomy. CONCLUSIONS:
      Robotic surgery achieves at least the same level of operation technique for
      pneumonectomy and lymph node dissection under standard open thoracotomy, and it
      seemed as safe and easily performed as conventional VATS. The training program
      using pigs was effective and holds promise as a system to train thoracic surgeons
      in robotic lung surgery.
FAU - Kajiwara, Naohiro
AU  - Kajiwara N
AD  - Department of Thoracic Surgery, Tokyo Medical University, Tokyo, Japan.
FAU - Kakihana, Masatoshi
AU  - Kakihana M
FAU - Usuda, Jitsuo
AU  - Usuda J
FAU - Uchida, Osamu
AU  - Uchida O
FAU - Ohira, Tatsuo
AU  - Ohira T
FAU - Kawate, Norihiko
AU  - Kawate N
FAU - Ikeda, Norihiko
AU  - Ikeda N
LA  - eng
PT  - Journal Article
DEP - 20110713
PL  - Japan
TA  - Ann Thorac Cardiovasc Surg
JT  - Annals of thoracic and cardiovascular surgery : official journal of the
      Association of Thoracic and Cardiovascular Surgeons of Asia
JID - 9703158
SB  - IM
MH  - Animals
MH  - Certification
MH  - Clinical Competence
MH  - Education, Medical, Graduate/*methods
MH  - Endoscopes
MH  - Equipment Design
MH  - Feasibility Studies
MH  - Humans
MH  - Lymph Node Excision/*education/instrumentation
MH  - Models, Animal
MH  - Motor Skills
MH  - Pneumonectomy/*education/instrumentation
MH  - Robotics/*education/instrumentation
MH  - Surgery, Computer-Assisted/*education/instrumentation
MH  - Swine
MH  - Thoracic Surgery, Video-Assisted/*education/instrumentation
EDAT- 2011/09/02 06:00
MHDA- 2012/02/18 06:00
CRDT- 2011/09/02 06:00
PHST- 2011/09/02 06:00 [entrez]
PHST- 2011/09/02 06:00 [pubmed]
PHST- 2012/02/18 06:00 [medline]
AID - JST.JSTAGE/atcs/oa.10.01613 [pii]
AID - 10.5761/atcs.oa.10.01613 [doi]
PST - ppublish
SO  - Ann Thorac Cardiovasc Surg. 2011;17(5):446-53. doi: 10.5761/atcs.oa.10.01613.
      Epub 2011 Jul 13.


PMID- 21881063
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20190709
IS  - 1943-4723 (Electronic)
IS  - 0002-8177 (Linking)
VI  - 142
IP  - 9
DP  - 2011 Sep
TI  - Ethical injections.
PG  - 999-1002; author reply 1002-3
FAU - Malcmacher, Louis
AU  - Malcmacher L
LA  - eng
PT  - Letter
PT  - Comment
PL  - England
TA  - J Am Dent Assoc
JT  - Journal of the American Dental Association (1939)
JID - 7503060
SB  - IM
CON - J Am Dent Assoc. 2011 Mar;142(3):335-7. PMID: 21357869
EIN - J Am Dent Assoc. 2011 Nov;142(11):1240
EIN - J Am Dent Assoc. 2011 Oct;142(10):1128
MH  - Cosmetic Techniques/*ethics
MH  - Dentists/*ethics
MH  - *Ethics, Dental
MH  - Humans
EDAT- 2011/09/02 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/09/02 06:00
PHST- 2011/09/02 06:00 [entrez]
PHST- 2011/09/02 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - S0002-8177(14)62460-0 [pii]
AID - 10.14219/jada.archive.2011.0308 [doi]
PST - ppublish
SO  - J Am Dent Assoc. 2011 Sep;142(9):999-1002; author reply 1002-3. doi:
      10.14219/jada.archive.2011.0308.


PMID- 21880513
OWN - NLM
STAT- MEDLINE
DCOM- 20111213
LR  - 20111031
IS  - 1879-1190 (Electronic)
IS  - 1072-7515 (Linking)
VI  - 213
IP  - 5
DP  - 2011 Nov
TI  - Ethical management of conflict of interest: proposed standards for academic
      surgical societies.
PG  - 677-82
LID - 10.1016/j.jamcollsurg.2011.08.003 [doi]
AB  - BACKGROUND: A significant increase in industry support of professional medical
      associations coupled with data suggesting that gifts from industry have
      significant clinical influence have prompted calls from the Institute of Medicine
      and physician leaders to identify and manage conflicts of interest that stem from
      financial support of professional medical associations by industry. STUDY DESIGN:
      A joint task force of members appointed by the Association for Academic Surgery
      and the Society of University Surgeons was convened in July 2009. Recommendations
      were developed regarding management of all potential conflicts of interest that
      can arise within the context of an academic surgical society, with specific focus
      on relationships with industry. Task force members reached consensus around each 
      recommendation and the guidelines were subsequently adopted by the Executive
      Councils of both societies. RESULTS: The committee identified 4 primary areas of 
      need for transparent and definitive management of conflict of interest: 1)
      individual society activities, including general budget support, society
      endorsements, and journal affiliation; 2) individual personnel conflicts such as 
      society leadership and standards for disclosure of conflict; 3) meeting
      activities including budgetary support, program committee associations, and
      abstract review process; and 4) foundation support and research and travel
      awards. The resulting guidelines aim to protect the societies and their
      membership from undue bias that may undermine the credibility and mission of
      these associations. CONCLUSIONS: Policy guidelines to mitigate conflict of
      interest are necessary to protect the integrity of the work of academic surgical 
      societies and their fiduciary duty to members and patients. Guidelines created
      and adopted by the Association for Academic Surgery and Society of University
      Surgeons form an effective model for academic surgical societies and their
      members.
CI  - Copyright (c) 2011 American College of Surgeons. All rights reserved.
FAU - Minter, Rebecca M
AU  - Minter RM
AD  - University of Michigan Hospital, Ann Arbor, MI, USA. rminter@med.umich.edu
FAU - Angelos, Peter
AU  - Angelos P
FAU - Coimbra, Raul
AU  - Coimbra R
FAU - Dale, Paul
AU  - Dale P
FAU - de Vera, Michael E
AU  - de Vera ME
FAU - Hardacre, Jeff
AU  - Hardacre J
FAU - Hawkins, William
AU  - Hawkins W
FAU - Kirkwood, Kimberly
AU  - Kirkwood K
FAU - Matthews, Jeffrey B
AU  - Matthews JB
FAU - McLoughlin, James
AU  - McLoughlin J
FAU - Peralta, Elizabeth
AU  - Peralta E
FAU - Schmidt, Max
AU  - Schmidt M
FAU - Zhou, Wei
AU  - Zhou W
FAU - Schwarze, Margaret L
AU  - Schwarze ML
LA  - eng
PT  - Journal Article
DEP - 20110831
PL  - United States
TA  - J Am Coll Surg
JT  - Journal of the American College of Surgeons
JID - 9431305
SB  - IM
MH  - Advisory Committees
MH  - *Conflict of Interest
MH  - Consensus Development Conferences as Topic
MH  - Ethics, Medical
MH  - Financial Support
MH  - Humans
MH  - Interpersonal Relations
MH  - Leadership
MH  - Organizational Policy
MH  - Societies, Medical/economics/*ethics/*standards/trends
MH  - *Specialties, Surgical
MH  - Truth Disclosure
MH  - United States
EDAT- 2011/09/02 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/09/02 06:00
PHST- 2011/07/14 00:00 [received]
PHST- 2011/08/02 00:00 [accepted]
PHST- 2011/09/02 06:00 [entrez]
PHST- 2011/09/02 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - S1072-7515(11)00976-8 [pii]
AID - 10.1016/j.jamcollsurg.2011.08.003 [doi]
PST - ppublish
SO  - J Am Coll Surg. 2011 Nov;213(5):677-82. doi: 10.1016/j.jamcollsurg.2011.08.003.
      Epub 2011 Aug 31.


PMID- 21879864
OWN - NLM
STAT- MEDLINE
DCOM- 20120103
LR  - 20130520
IS  - 1440-1665 (Electronic)
IS  - 1039-8562 (Linking)
VI  - 19
IP  - 4
DP  - 2011 Aug
TI  - Dangerous "spin": the probability myth of evidence-based prescribing - a
      Merleau-Pontyian approach.
PG  - 295-300
LID - 10.3109/10398562.2011.603333 [doi]
AB  - OBJECTIVE: The aim of this study was to examine logical positivist statistical
      probability statements used to support and justify "evidence-based" prescribing
      rules in psychiatry when viewed from the major philosophical theories of
      probability, and to propose "phenomenological probability" based on Maurice
      Merleau-Ponty's philosophy of "phenomenological positivism" as a better clinical 
      and ethical basis for psychiatric prescribing. CONCLUSIONS: The logical
      positivist statistical probability statements which are currently used to support
      "evidence-based" prescribing rules in psychiatry have little clinical or ethical 
      justification when subjected to critical analysis from any of the major theories 
      of probability and represent dangerous "spin" because they necessarily exclude
      the individual , intersubjective and ambiguous meaning of mental illness. A
      concept of "phenomenological probability" founded on Merleau-Ponty's philosophy
      of "phenomenological positivism" overcomes the clinically destructive
      "objectivist" and "subjectivist" consequences of logical positivist statistical
      probability and allows psychopharmacological treatments to be appropriately
      integrated into psychiatric treatment.
FAU - Morstyn, Ron
AU  - Morstyn R
AD  - ronmorstyn@bigpond.com
LA  - eng
PT  - Journal Article
PL  - England
TA  - Australas Psychiatry
JT  - Australasian psychiatry : bulletin of Royal Australian and New Zealand College of
      Psychiatrists
JID - 9613603
SB  - IM
MH  - *Drug Prescriptions
MH  - *Evidence-Based Medicine
MH  - Humans
MH  - Knowledge
MH  - Mental Disorders/*drug therapy/psychology
MH  - Philosophy
MH  - Probability
MH  - *Psychiatry
EDAT- 2011/09/02 06:00
MHDA- 2012/01/04 06:00
CRDT- 2011/09/02 06:00
PHST- 2011/09/02 06:00 [entrez]
PHST- 2011/09/02 06:00 [pubmed]
PHST- 2012/01/04 06:00 [medline]
AID - 10.3109/10398562.2011.603333 [doi]
PST - ppublish
SO  - Australas Psychiatry. 2011 Aug;19(4):295-300. doi: 10.3109/10398562.2011.603333.


PMID- 21879822
OWN - NLM
STAT- MEDLINE
DCOM- 20111223
LR  - 20160701
IS  - 1745-5065 (Electronic)
IS  - 1745-5057 (Linking)
VI  - 7
IP  - 5
DP  - 2011 Sep
TI  - Fertility preservation in women with cancer: importance of a multidisciplinary
      approach.
PG  - 537-43
LID - 10.2217/whe.11.40 [doi]
AB  - For all patients affected by a disease that could impair fertility before or
      during the reproductive lifespan, strategies to preserve their fertility and the 
      ability to bear their own children is likely to be of utmost importance. While
      fertility preservation is a promising option, most of the technologies currently 
      used are far from being well-established or are still experimental. Patients
      should be aware that no method guarantees success. Psychological and ethical
      impacts of fertility preservation are major concerns and should be included in
      the multidisciplinary approach to the patients.
FAU - Treves, Rachel
AU  - Treves R
AD  - Departments of Obstetrics & Gynecology & Reproductive Medicine, Universite Paris 
      XI, Institut National de la Sante et de la Recherche Medicale U782, Hopital
      Antoine Beclere, Clamart, France. rachel.treves@abc.aphp.fr
FAU - Grynberg, Michael
AU  - Grynberg M
FAU - Hesters, Laetitia
AU  - Hesters L
FAU - Frydman, Rene
AU  - Frydman R
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Womens Health (Lond)
JT  - Women's health (London, England)
JID - 101271249
RN  - 0 (Antineoplastic Agents, Alkylating)
RN  - 8N3DW7272P (Cyclophosphamide)
SB  - IM
MH  - Antineoplastic Agents, Alkylating/adverse effects
MH  - Cryopreservation/ethics/*methods
MH  - Cyclophosphamide/adverse effects
MH  - Decision Making
MH  - Female
MH  - Fertility Preservation/ethics/*methods/*psychology
MH  - Humans
MH  - *Neoplasms/drug therapy/psychology/radiotherapy
EDAT- 2011/09/02 06:00
MHDA- 2011/12/24 06:00
CRDT- 2011/09/02 06:00
PHST- 2011/09/02 06:00 [entrez]
PHST- 2011/09/02 06:00 [pubmed]
PHST- 2011/12/24 06:00 [medline]
AID - 10.2217/whe.11.40 [doi]
PST - ppublish
SO  - Womens Health (Lond). 2011 Sep;7(5):537-43. doi: 10.2217/whe.11.40.


PMID- 21879607
OWN - NLM
STAT- MEDLINE
DCOM- 20111006
LR  - 20191112
IS  - 0007-0874 (Print)
IS  - 0007-0874 (Linking)
VI  - 44
IP  - 161 Pt 2
DP  - 2011 Jun
TI  - 'Sexual chemistry' before the pill: science, industry and chemical
      contraceptives, 1920-1960.
PG  - 245-74
AB  - The history of contraceptives met the history of drugs long before the invention 
      of the contraceptive pill. In the first half of the twentieth century, numerous
      pharmaceutical laboratories, including major ones, manufactured and marketed
      chemical contraceptives: jellies, suppositories, creams, powders and foams
      applied locally to prevent conception. Efforts to put an end to the marginal
      status of these products and to transform them into 'ethical' drugs played an
      important role in the development of standardized laboratory tests of efficacy of
      contraceptive preparations; debates on the validity of such tests; evaluation of 
      the long-term toxicity of chemical compounds; and the rise of collaborations
      between activists, non-profit organizations and the pharmaceutical industry.
      Chemical contraceptives were initially associated with quack medicine, shady
      commercial practices and doubtful morality. Striving to change the status of
      contraceptives and to promote safe and efficient products that reduced fertility 
      in humans shaped some of the key features of the present-day production and
      regulation of pharmaceuticals.
FAU - Lowy, Ilana
AU  - Lowy I
AD  - CERMES (INSERM, CNRS, EHESS), 7 rue Guy Moquet, 94801 Vuillejuif cedex, France.
      lowy@vjf.cnrs.fr
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - England
TA  - Br J Hist Sci
JT  - British journal for the history of science
JID - 0144554
RN  - 0 (Spermatocidal Agents)
RN  - 0 (Vaginal Creams, Foams, and Jellies)
RN  - OSX88361UX (Phenylmercuric Acetate)
MH  - Drug-Related Side Effects and Adverse Reactions/history
MH  - History, 20th Century
MH  - Humans
MH  - Phenylmercuric Acetate/history
MH  - Spermatocidal Agents/*history
MH  - United Kingdom
MH  - United States
MH  - Vaginal Creams, Foams, and Jellies/history
EDAT- 2011/09/02 06:00
MHDA- 2011/10/07 06:00
CRDT- 2011/09/02 06:00
PHST- 2011/09/02 06:00 [entrez]
PHST- 2011/09/02 06:00 [pubmed]
PHST- 2011/10/07 06:00 [medline]
AID - 10.1017/s0007087410000762 [doi]
PST - ppublish
SO  - Br J Hist Sci. 2011 Jun;44(161 Pt 2):245-74. doi: 10.1017/s0007087410000762.


PMID- 21879582
OWN - NLM
STAT- MEDLINE
DCOM- 20111006
LR  - 20191112
IS  - 0955-2359 (Print)
IS  - 0955-2359 (Linking)
VI  - 22
IP  - 1
DP  - 2011
TI  - Youth crime and preventive policing in post-war Scotland (c.1945-71).
PG  - 79-102
AB  - This article explores debates concerning the methods and styles used by the
      police service in its dealings with children and young people in post-war
      Scotland (in comparison with England). Study of the implementation of Police
      Juvenile Liaison Schemes is used to consider shifting points of tension as well
      as cooperation between the police and other occupational groups engaged in work
      at the nexus of youth justice-welfare. Whilst often characterized as
      contradictory tendencies, the article demonstrates that a social welfare ethic
      and a criminal justice ethic were coexistent within the rhetoric and practice of 
      policing, but that they operated in a state of flux. It also argues that styles
      of policing were subject to change, particularly as the use of discretionary and 
      informal methods was increasingly challenged, as physical violence was
      increasingly seen as an outmoded recourse for the institutions of criminal
      justice, and as the policing of youth was increasingly politicized. The post-war 
      period can be characterized in terms of greater levels of public scrutiny, the
      formalization of processes previously undertaken through informal or semi-formal 
      mechanisms, and attempts (not always successful) to systematize procedures
      nationally in terms of the Scottish state.
FAU - Bartie, Angela
AU  - Bartie A
AD  - Faculty of Humanities and Social Sciences, University of Strathclyde.
FAU - Jackson, Louise A
AU  - Jackson LA
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - 20 Century Br Hist
JT  - 20 century British history
JID - 9015384
MH  - Adolescent
MH  - Child
MH  - Female
MH  - History, 20th Century
MH  - Humans
MH  - Juvenile Delinquency/*history/prevention & control
MH  - Male
MH  - Police/*history
MH  - Scotland
MH  - Social Work/*history
EDAT- 2011/09/02 06:00
MHDA- 2011/10/07 06:00
CRDT- 2011/09/02 06:00
PHST- 2011/09/02 06:00 [entrez]
PHST- 2011/09/02 06:00 [pubmed]
PHST- 2011/10/07 06:00 [medline]
AID - 10.1093/tcbh/hwq038 [doi]
PST - ppublish
SO  - 20 Century Br Hist. 2011;22(1):79-102. doi: 10.1093/tcbh/hwq038.


PMID- 21879357
OWN - NLM
STAT- MEDLINE
DCOM- 20120727
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 17
IP  - 4
DP  - 2011 Dec
TI  - Constitutional moments in governing science and technology.
PG  - 621-38
LID - 10.1007/s11948-011-9302-2 [doi]
AB  - Scholars in science and technology studies (STS) have recently been called upon
      to advise governments on the design of procedures for public engagement. Any such
      instrumental function should be carried out consistently with STS's interpretive 
      and normative obligations as a social science discipline. This article
      illustrates how such threefold integration can be achieved by reviewing current
      US participatory politics against a 70-year backdrop of tacit constitutional
      developments in governing science and technology. Two broad cycles of
      constitutional adjustment are discerned: the first enlarging the scope of state
      action as well as public participation, with liberalized rules of access and
      sympathetic judicial review; the second cutting back on the role of the state,
      fostering the rise of an academic-industrial complex for technology transfer, and
      privatizing value debates through increasing delegation to professional
      ethicists. New rules for public engagement in the United Sates should take
      account of these historical developments and seek to counteract some of the
      anti-democratic tendencies observable in recent decades.
FAU - Jasanoff, Sheila
AU  - Jasanoff S
AD  - John F. Kennedy School of Government, Harvard University, Cambridge, MA, USA.
      sjasan@fas.harvard.edu
LA  - eng
PT  - Historical Article
PT  - Journal Article
DEP - 20110831
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
CIN - Sci Eng Ethics. 2011 Dec;17(4):639-48. PMID: 21785999
MH  - Community Participation/*history
MH  - Democracy
MH  - Federal Government/history
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Politics
MH  - Public Policy/*history
MH  - Science/ethics/*history
MH  - Social Sciences/ethics/*history
MH  - Social Values/*history
MH  - Technology/ethics/*history
MH  - United States
MH  - Universities/history
EDAT- 2011/09/01 06:00
MHDA- 2012/07/28 06:00
CRDT- 2011/09/01 06:00
PHST- 2008/07/06 00:00 [received]
PHST- 2011/05/04 00:00 [accepted]
PHST- 2011/09/01 06:00 [entrez]
PHST- 2011/09/01 06:00 [pubmed]
PHST- 2012/07/28 06:00 [medline]
AID - 10.1007/s11948-011-9302-2 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2011 Dec;17(4):621-38. doi: 10.1007/s11948-011-9302-2. Epub 2011 
      Aug 31.


PMID- 21879194
OWN - NLM
STAT- MEDLINE
DCOM- 20120604
LR  - 20110831
IS  - 0717-6163 (Electronic)
IS  - 0034-9887 (Linking)
VI  - 139
IP  - 4
DP  - 2011 Apr
TI  - [Bioethics of Sigmund Freud s death: euthanasia or appropriation?].
PG  - 529-34
LID - /S0034-98872011000400017 [doi]
AB  - The death of Freud raises the ethical dilemma about euthanasia. It can be
      characterized as indirect active euthanasia according to the rule of double
      effect, or terminal sedation, or palliated death. The primacy of the principle of
      autonomy over non maleficence, conditioned the physician's attitude toward his
      patient Freud. The physician assisted death was and remains punishable in western
      medicine. Therefore, a fundamental tradition was infringed. In contrast, the
      present study attempts to characterize the final position of Freud himself to his
      death and called it appropriation of his finitude; he assumes his
      being-unto-death, that is, he now projects his being not as a being-at-his-end
      but as a being-unto-end, indicating thereby that he understood that the end
      always penetrated his whole existence.
FAU - Figueroa, Gustavo
AU  - Figueroa G
AD  - Departamento de Psiquiatria, Escuela de Medicina, Universidad de Valparaiso,
      Valparaiso, Chile. gfigueroacave@gmail.com
LA  - spa
PT  - Biography
PT  - English Abstract
PT  - Historical Article
PT  - Journal Article
TT  - Bioetica de la muerte de Sigmund Freud: inverted question markEutanasia o
      apropiacion?
DEP - 20110825
PL  - Chile
TA  - Rev Med Chil
JT  - Revista medica de Chile
JID - 0404312
SB  - IM
MH  - Bioethical Issues/history
MH  - Carcinoma, Squamous Cell/history
MH  - Euthanasia, Active/*ethics/*history
MH  - History, 19th Century
MH  - History, 20th Century
MH  - Humans
MH  - Palatal Neoplasms/history
MH  - Patient Rights/ethics
MH  - Personal Autonomy
MH  - Psychoanalysis/*history
PS  - Freud S
FPS - Freud, Sigmund
EDAT- 2011/09/01 06:00
MHDA- 2012/06/05 06:00
CRDT- 2011/09/01 06:00
PHST- 2011/09/01 06:00 [entrez]
PHST- 2011/09/01 06:00 [pubmed]
PHST- 2012/06/05 06:00 [medline]
AID - S0034-98872011000400017 [pii]
AID - /S0034-98872011000400017 [doi]
PST - ppublish
SO  - Rev Med Chil. 2011 Apr;139(4):529-34. doi: /S0034-98872011000400017. Epub 2011
      Aug 25.


PMID- 21878454
OWN - NLM
STAT- MEDLINE
DCOM- 20120529
LR  - 20220408
IS  - 1477-0970 (Electronic)
IS  - 1352-4585 (Linking)
VI  - 18
IP  - 2
DP  - 2012 Feb
TI  - A placebo-controlled, parallel-group, randomized withdrawal study of subjects
      with symptoms of spasticity due to multiple sclerosis who are receiving long-term
      Sativex(R) (nabiximols).
PG  - 219-28
LID - 10.1177/1352458511419700 [doi]
AB  - BACKGROUND: Open-label studies are not ideal for providing robust evidence for
      long-term maintenance of efficacy of medicines, especially where medicines
      provide symptom relief and where long-term use of a placebo may be problematic
      and not ethical. OBJECTIVE: To evaluate the maintenance of efficacy of Sativex in
      subjects who have gained long-term symptomatic relief of spasticity in multiple
      sclerosis (MS), and to assess the impact of sudden medicine withdrawal. METHODS: 
      An enriched enrolment randomized withdrawal study design was used. Eligible
      subjects with ongoing benefit from Sativex for at least 12 weeks entered this
      5-week placebo-controlled, parallel-group, randomized withdrawal study. Each
      subjects' previous effective and tolerated dose was continued. RESULTS: A total
      of 18 subjects per group were enrolled. Demographics showed a mean duration of MS
      of 16.4 years, spasticity 12.7 years, mean duration of Sativex use of 3.6 years
      (median 3.4 years) and a mean daily dose of 8.25 sprays. Primary outcome of time 
      to treatment failure was significantly in favour of Sativex (p = 0.013).
      Secondary endpoints showed significant changes in the Carer and Subject's Global 
      Impression of Change scales in favour of Sativex. CONCLUSIONS: Maintenance of
      Sativex efficacy in long-term symptomatic improvement of spasticity to a group of
      subjects with MS has been confirmed using this study design.
FAU - Notcutt, W
AU  - Notcutt W
AD  - James Paget University Hospital, Pain Management Department, Gorleston on Sea,
      UK. william.notcutt@jpaget.nhs.uk
FAU - Langford, R
AU  - Langford R
FAU - Davies, P
AU  - Davies P
FAU - Ratcliffe, S
AU  - Ratcliffe S
FAU - Potts, R
AU  - Potts R
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110830
PL  - England
TA  - Mult Scler
JT  - Multiple sclerosis (Houndmills, Basingstoke, England)
JID - 9509185
RN  - 0 (Cannabinoids)
RN  - 0 (Drug Combinations)
RN  - 0 (Placebos)
RN  - 0 (Plant Extracts)
RN  - 19GBJ60SN5 (Cannabidiol)
RN  - 7J8897W37S (Dronabinol)
RN  - K4H93P747O (nabiximols)
SB  - IM
MH  - Aged
MH  - Cannabidiol
MH  - Cannabinoids/administration & dosage/*adverse effects
MH  - Dronabinol
MH  - Drug Combinations
MH  - Female
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis, Chronic Progressive/complications/*drug therapy
MH  - Multiple Sclerosis, Relapsing-Remitting/complications/*drug therapy
MH  - Muscle Spasticity/diagnosis/*drug therapy/etiology
MH  - Placebos
MH  - Plant Extracts/administration & dosage/*adverse effects
MH  - Substance Withdrawal Syndrome/*diagnosis
EDAT- 2011/09/01 06:00
MHDA- 2012/05/30 06:00
CRDT- 2011/09/01 06:00
PHST- 2011/09/01 06:00 [entrez]
PHST- 2011/09/01 06:00 [pubmed]
PHST- 2012/05/30 06:00 [medline]
AID - 1352458511419700 [pii]
AID - 10.1177/1352458511419700 [doi]
PST - ppublish
SO  - Mult Scler. 2012 Feb;18(2):219-28. doi: 10.1177/1352458511419700. Epub 2011 Aug
      30.


PMID- 21878193
OWN - NLM
STAT- MEDLINE
DCOM- 20120321
LR  - 20220309
IS  - 1944-7930 (Electronic)
IS  - 1539-6509 (Linking)
VI  - 12
IP  - 63
DP  - 2011 Aug
TI  - Pharmacogenomics in ophthalmology.
PG  - 159-67
AB  - Inter-individual variation in drug response and adverse drug reactions (ADRs) are
      well known in medicine. This individual variation in drug response could be at
      least, in part, due to genetic diversity among individuals. Although substantial 
      studies that connect genetic variants to inter-individual variation in drug
      response have been documented in several diseases such as cancer and heart
      diseases, such studies are slowly progressing in ophthalmology. In recent years, 
      advancement in technologies has led to the identification of genes associated
      with several eye disorders. At the same time, some small-scale studies have
      demonstrated the association of various genotypes or haplotypes with response to 
      drug therapies. However, its integration into clinical practice in ophthalmology 
      is not possible at present. This is because there are many challenging questions 
      that remain to be addressed. For instance, in the case of complex disorders a
      single gene study is not enough. Multiple genes, environmental factors, multiple 
      single nucleotide polymorphisms (SNPs), and rare or low frequency variants may
      contribute to the disease and they must be considered. The functional aspects of 
      many genetic variants are not known. This raises questions of their biological
      importance and their clinical usefulness. In addition, there are legal, ethical, 
      and social issues that need to be regulated. Moreover, physicians and patients
      must be educated about the limitation and sensitivity of genetic testing. At
      present pharmacogenetic studies in ophthalmology are still in their infancy and
      do not suggest that a pharmacogenetic basis of drug development in ophthalmology 
      is a concept that can yield immediate results, but can become a reality in the
      future. In this article an attempt has been made to summarize some of the recent 
      small-scale pharmacogenetic studies on two major eye disorders, age-related
      macular degeneration (AMD) and glaucoma.
FAU - Shastry, Barkur S
AU  - Shastry BS
AD  - Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA. 
      shastry@oakland.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Discov Med
JT  - Discovery medicine
JID - 101250006
SB  - IM
MH  - Genetic Predisposition to Disease
MH  - Glaucoma/genetics
MH  - Humans
MH  - Macular Degeneration/genetics
MH  - Ophthalmology/*methods
MH  - Pharmacogenetics/*methods
EDAT- 2011/09/01 06:00
MHDA- 2012/03/22 06:00
CRDT- 2011/09/01 06:00
PHST- 2011/09/01 06:00 [entrez]
PHST- 2011/09/01 06:00 [pubmed]
PHST- 2012/03/22 06:00 [medline]
PST - ppublish
SO  - Discov Med. 2011 Aug;12(63):159-67.


PMID- 21878061
OWN - NLM
STAT- MEDLINE
DCOM- 20120202
LR  - 20110928
IS  - 1476-4954 (Electronic)
IS  - 1476-4954 (Linking)
VI  - 24 Suppl 1
DP  - 2011 Oct
TI  - Italia-Netherland PhD Program: the I.O. PhD Research Program.
PG  - 111-3
LID - 10.3109/14767058.2011.607662 [doi]
AB  - In the framework of long-term scientific collaboration among the founder members 
      coming from Holland and Italy there was a growing consensus to activate a
      philosophical doctorate (PhD) program, involving young Italian researchers in the
      field of perinatal medicine, neonatology and pediatrics. The aims were to promote
      excellence in research, offering to young Italian physicians the opportunity to
      maturate an International research experience leading to PhD degree, and to
      promote human and technological improvement energies in perinatal, neonatal and
      pediatrics research. Thus, an official collaboration among the Dutch Universities
      from Maastricht and Utrecht and the Italian Children's Hospital from Alessandria,
      has been activated on March 1st 2010, finalized to the PhD program. The
      experimental phase included the selection of projects and relative candidates
      after an interview-selection focusing on their scientific attitudes and the
      availability on their research projects. Candidates' selection started on May
      2010 and on September 29th ten projects and candidates have been approved by the 
      scientific commission. Research topics included: perinatal asphyxia, aging and
      the origin of adulthood neurodegenerative disease, neuroprotective strategies,
      biochemical pulmonology, intrauterine growth retardation and perinatal
      teratology. To date, all projects have been approved by local Ethics Committee
      from the University/Hospital of origin of the candidates. Five manuscripts have
      been published and/or submitted to international Journals regarding pneumology,
      perinatal asphyxia and teratology, whilst about 60-70% of data regarding clinical
      studies have already been collected.
FAU - Bellissima, Valentina
AU  - Bellissima V
AD  - Department of Maternal, Fetal and Neonatal Medicine, C. Arrigo Children's
      Hospital, Alessandria, Italy.
FAU - Borghesi, Alessandro
AU  - Borghesi A
FAU - Bozzetti, Valentina
AU  - Bozzetti V
FAU - Dessi, Angelica
AU  - Dessi A
FAU - Fabiano, Adele
AU  - Fabiano A
FAU - Risso, Francesco M
AU  - Risso FM
FAU - Salvo, Vincenzo
AU  - Salvo V
FAU - Satriano, Angela
AU  - Satriano A
FAU - Silvagni, Davide
AU  - Silvagni D
FAU - Varrica, Alessandro
AU  - Varrica A
FAU - van Bel, Frank
AU  - van Bel F
FAU - Visser, Gerard H A
AU  - Visser GH
FAU - Vles, Hans Js
AU  - Vles HJ
FAU - Zimmermann, Luc J I
AU  - Zimmermann LJ
FAU - Gavilanes, Antonio D W
AU  - Gavilanes AD
FAU - Gazzolo, Diego
AU  - Gazzolo D
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20110831
PL  - England
TA  - J Matern Fetal Neonatal Med
JT  - The journal of maternal-fetal & neonatal medicine : the official journal of the
      European Association of Perinatal Medicine, the Federation of Asia and Oceania
      Perinatal Societies, the International Society of Perinatal Obstetricians
JID - 101136916
SB  - IM
MH  - Biomedical Research/*education/methods/organization & administration
MH  - Child
MH  - Education, Medical, Graduate/methods/*organization & administration
MH  - Female
MH  - Fetal Growth Retardation/diagnosis/etiology/therapy
MH  - Humans
MH  - Hypoxia-Ischemia, Brain/diagnosis/etiology/therapy
MH  - Infant, Newborn
MH  - International Cooperation
MH  - Italy
MH  - Neonatology/*education/methods/organization & administration
MH  - Netherlands
MH  - Pediatrics/*education/methods/organization & administration
MH  - Perinatology/*education/methods/organization & administration
MH  - Pregnancy
MH  - Research Design
MH  - Universities
MH  - Vocational Education/methods/organization & administration
EDAT- 2011/09/01 06:00
MHDA- 2012/02/03 06:00
CRDT- 2011/09/01 06:00
PHST- 2011/09/01 06:00 [entrez]
PHST- 2011/09/01 06:00 [pubmed]
PHST- 2012/02/03 06:00 [medline]
AID - 10.3109/14767058.2011.607662 [doi]
PST - ppublish
SO  - J Matern Fetal Neonatal Med. 2011 Oct;24 Suppl 1:111-3. doi:
      10.3109/14767058.2011.607662. Epub 2011 Aug 31.


PMID- 21877972
OWN - NLM
STAT- MEDLINE
DCOM- 20111110
LR  - 20181201
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 11
IP  - 9
DP  - 2011 Sep
TI  - The conundrum of oocyte donation, human research, OHSS, and ethics.
PG  - 35-7
LID - 10.1080/15265161.2011.593685 [doi]
FAU - Stein, Andrea L
AU  - Stein AL
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2011 Sep;11(9):22-30. PMID: 21877969
MH  - Female
MH  - Humans
MH  - Nuclear Transfer Techniques/*ethics
MH  - Oocyte Donation/*adverse effects/*economics
MH  - Ovarian Hyperstimulation Syndrome/*etiology
MH  - Reproductive Techniques, Assisted/*ethics
MH  - Stem Cell Research/*ethics
EDAT- 2011/09/01 06:00
MHDA- 2011/11/11 06:00
CRDT- 2011/09/01 06:00
PHST- 2011/09/01 06:00 [entrez]
PHST- 2011/09/01 06:00 [pubmed]
PHST- 2011/11/11 06:00 [medline]
AID - 10.1080/15265161.2011.593685 [doi]
PST - ppublish
SO  - Am J Bioeth. 2011 Sep;11(9):35-7. doi: 10.1080/15265161.2011.593685.


PMID- 21877971
OWN - NLM
STAT- MEDLINE
DCOM- 20111110
LR  - 20181201
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 11
IP  - 9
DP  - 2011 Sep
TI  - Ethical concerns eliminated: safer stimulation protocols and egg banking.
PG  - 33-5
LID - 10.1080/15265161.2011.593686 [doi]
FAU - Mertes, Heidi
AU  - Mertes H
FAU - Pennings, Guido
AU  - Pennings G
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2011 Sep;11(9):22-30. PMID: 21877969
MH  - Female
MH  - Humans
MH  - Nuclear Transfer Techniques/*ethics
MH  - Oocyte Donation/*adverse effects/*economics
MH  - Ovarian Hyperstimulation Syndrome/*etiology
MH  - Reproductive Techniques, Assisted/*ethics
MH  - Stem Cell Research/*ethics
EDAT- 2011/09/01 06:00
MHDA- 2011/11/11 06:00
CRDT- 2011/09/01 06:00
PHST- 2011/09/01 06:00 [entrez]
PHST- 2011/09/01 06:00 [pubmed]
PHST- 2011/11/11 06:00 [medline]
AID - 10.1080/15265161.2011.593686 [doi]
PST - ppublish
SO  - Am J Bioeth. 2011 Sep;11(9):33-5. doi: 10.1080/15265161.2011.593686.


PMID- 21877472
OWN - NLM
STAT- MEDLINE
DCOM- 20111102
LR  - 20170203
IS  - 0723-1393 (Print)
IS  - 0723-1393 (Linking)
VI  - 30
IP  - 2
DP  - 2011 Jun
TI  - Can hospitals prohibit euthanasia? An analysis from a European human rights
      perspective.
PG  - 295-306
AB  - At present, in four European countries euthanasia and/ or physician assisted
      suicide (PAS) are tolerated under strict legal conditions. However, in practice
      these patient groups are often deprived of the possibility to undergo such
      decisions. Particularly Catholic health care institutions have developed policies
      which restrict the internal application of the law. Yet, the legitimacy of such
      policies is questionable. From a European human rights perspective it can be
      defended that the freedom of association allows hospitals to develop policies
      elaborating their ethical stances on euthanasia and PAS. However, to respect the 
      patient's right to self-determination the concerned hospitals should at least
      inform current and future patients about the restrictive policy and deal
      carefully with euthanasia and PAS requests. If a patient's wish remains seriously
      incompatible with the ethical stances of the hospital, at least reasonable and
      attainable alternatives (such as a referral to a tolerant regional hospital)
      should be offered.
FAU - Tack, Sylvie
AU  - Tack S
AD  - Ghent University & Vrije Universiteit Brussel. Sylvie.Tack@Ugent.be
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Law
JT  - Medicine and law
JID - 8218185
SB  - IM
MH  - Europe
MH  - Euthanasia/*legislation & jurisprudence
MH  - *Hospitals
MH  - Human Rights/*legislation & jurisprudence
MH  - Humans
MH  - *Organizational Policy
EDAT- 2011/09/01 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/09/01 06:00
PHST- 2011/09/01 06:00 [entrez]
PHST- 2011/09/01 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
PST - ppublish
SO  - Med Law. 2011 Jun;30(2):295-306.


PMID- 21877466
OWN - NLM
STAT- MEDLINE
DCOM- 20111102
LR  - 20170203
IS  - 0723-1393 (Print)
IS  - 0723-1393 (Linking)
VI  - 30
IP  - 2
DP  - 2011 Jun
TI  - Italian ethical committee intervention in a case of embryo-fetal medicine.
PG  - 201-14
AB  - Embryo-fetal experimentation is intuitively associated with a therapeutic intent,
      according to a consolidated line of thought on the international and national
      levels. We report on a researcher's request for Ethics Committee approval to
      perform intrauterine transplantation of stem cells via cordocentesis on a fetus
      diagnosed with dystrophic epidermolysis bullosa, using stem cells obtained from a
      sibling's umbilical cord blood. The Ethics Committee rejected the request because
      of deontological issues and clinical judgments about the potential good to be
      derived from the procedure. In particular, in this case there was no preclinical 
      or animal research on the procedure, the risk factors for mother and fetus were
      unknown, there was no way to guarantee compliance with Italian laws regarding
      safety and quality of the donor cells, and there was lack of clear informed
      consent.
FAU - Cannovo, Nunzia
AU  - Cannovo N
AD  - Dipartimento di Medicina Pubblica e della Sicurezza Sociale--Sezione di Medicina 
      Legale. Universita degli Studi di Napoli, Federico II. drncannovo@libero.it
FAU - Buccelli, Paola
AU  - Buccelli P
FAU - Bryce, Jane
AU  - Bryce J
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Med Law
JT  - Medicine and law
JID - 8218185
SB  - IM
MH  - Child, Preschool
MH  - Cord Blood Stem Cell Transplantation/*ethics/legislation & jurisprudence
MH  - Epidermolysis Bullosa Dystrophica/therapy
MH  - Ethics Committees, Research
MH  - Female
MH  - Humans
MH  - Informed Consent/*ethics/legislation & jurisprudence
MH  - Italy
MH  - Male
MH  - Pregnancy
MH  - *Siblings
EDAT- 2011/09/01 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/09/01 06:00
PHST- 2011/09/01 06:00 [entrez]
PHST- 2011/09/01 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
PST - ppublish
SO  - Med Law. 2011 Jun;30(2):201-14.


PMID- 21877465
OWN - NLM
STAT- MEDLINE
DCOM- 20111102
LR  - 20170203
IS  - 0723-1393 (Print)
IS  - 0723-1393 (Linking)
VI  - 30
IP  - 2
DP  - 2011 Jun
TI  - The social, moral & ethical issues raised by nanotechnology in the field of
      medicine.
PG  - 187-200
AB  - The areas in medicine that are and will be influenced by nanoscale science and
      technology are stem cell research, genetic modification of human beings and the
      construction of artificial organisms. A non-negotiable moral imperative is the
      fact that the law is under an obligation to uphold the sanctity and integrity of 
      the human genome which encapsulates humankind's basic genetic inheritance and
      thereby the human heritage of our species. The research possibilities opened up
      by nanoscience will push the current boundaries of life forms, because they alter
      life forms at their most basic (viz genetic) level. They empower scientists to
      create novel life forms that would not otherwise exist and they combine aspects
      of different life forms that would not otherwise be integrated. These
      groundbreaking areas of research place the scientists and their work in an area
      of moral quicksands. Research involving human design and modification places
      those scientists in a domain where current morality indicates they do not belong.
      They are literally 'playing God'.
FAU - Lupton, Michael
AU  - Lupton M
AD  - Faculty of Law, Bond University, Gold Coast, Australia. mlupton@bond.edu.au
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Law
JT  - Medicine and law
JID - 8218185
SB  - IM
MH  - Ethics, Research
MH  - Health Policy
MH  - Humans
MH  - Informed Consent
MH  - Nanotechnology/*ethics/legislation & jurisprudence
MH  - Neoplasms/therapy
MH  - Safety
MH  - Social Responsibility
EDAT- 2011/09/01 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/09/01 06:00
PHST- 2011/09/01 06:00 [entrez]
PHST- 2011/09/01 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
PST - ppublish
SO  - Med Law. 2011 Jun;30(2):187-200.


PMID- 21877463
OWN - NLM
STAT- MEDLINE
DCOM- 20111102
LR  - 20170203
IS  - 0723-1393 (Print)
IS  - 0723-1393 (Linking)
VI  - 30
IP  - 2
DP  - 2011 Jun
TI  - Withdrawal and withholding of medical treatment: Czech medical law at the
      crossroads.
PG  - 169-78
AB  - The making of an end of life decision represents worldwide one of the most
      difficult issues that physicians can be confronted with --not only should it be
      regarded as consisting of medical and legal aspects, but ethics and moral values 
      are present as well. Furthermore, it shall not be supposed that the economic
      parameter is negligible, unfortunately even to the contrary. The fact that the
      decision is often made by physicians under pressure caused by a system of limited
      resources (and therefore it can not avoid being distorted) must be kept in mind. 
      At any rate , according to Czech law under which neither assisted suicide nor
      euthanasia is allowed, the legality and legitimacy of withdrawal and withholding 
      of medical treatment is based on the argument of informed consent of the patient,
      advanced directives and the standard of lege artis treatment. These also shall be
      pleaded as defences in eventual criminal proceedings.
FAU - Peterkova, Helena
AU  - Peterkova H
AD  - Centre of Medical Law, Law Faculty, Charles University, Prague.
      elenpeterkova@seznam.cz
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Law
JT  - Medicine and law
JID - 8218185
SB  - IM
MH  - Criminal Law
MH  - Czech Republic
MH  - Humans
MH  - Informed Consent/legislation & jurisprudence
MH  - Liability, Legal
MH  - Patient Rights/legislation & jurisprudence
MH  - Physicians/*legislation & jurisprudence
MH  - Suicide, Assisted/legislation & jurisprudence
MH  - Withholding Treatment/*legislation & jurisprudence
EDAT- 2011/09/01 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/09/01 06:00
PHST- 2011/09/01 06:00 [entrez]
PHST- 2011/09/01 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
PST - ppublish
SO  - Med Law. 2011 Jun;30(2):169-78.


PMID- 21867789
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20191210
IS  - 1552-6259 (Electronic)
IS  - 0003-4975 (Linking)
VI  - 92
IP  - 3 Suppl
DP  - 2011 Sep
TI  - Public reporting of cardiac surgery performance: Part 1--history, rationale,
      consequences.
PG  - S2-11
LID - 10.1016/j.athoracsur.2011.06.100 [doi]
AB  - Cardiac surgical report cards have historically been mandatory. This paradigm
      changed when The Society of Thoracic Surgeons recently implemented a voluntary
      public reporting program based on benchmark analyses from its National Cardiac
      Database. The primary rationale is to provide transparency and accountability,
      thus affirming the fundamental ethical right of patient autonomy. Previous
      studies suggest that public reporting facilitates quality improvement, although
      other approaches such as confidential feedback of results and regional quality
      improvement initiatives are also effective. Public reporting has not
      substantially impacted patient referral patterns or market share. However, this
      may change with implementation of healthcare reform and with refinement of public
      reporting formats to enhance consumer interpretability. Finally, the potential
      unintended adverse consequences of public reporting must be monitored,
      particularly to assure that hospitals and surgeons remain willing to care for
      high-risk patients.
CI  - Copyright (c) 2011 The Society of Thoracic Surgeons. Published by Elsevier Inc.
      All rights reserved.
FAU - Shahian, David M
AU  - Shahian DM
AD  - Department of Surgery and Center for Quality and Safety, Massachusetts General
      Hospital, Boston, Massachusetts 02114, USA. dshahian@partners.org
FAU - Edwards, Fred H
AU  - Edwards FH
FAU - Jacobs, Jeffrey P
AU  - Jacobs JP
FAU - Prager, Richard L
AU  - Prager RL
FAU - Normand, Sharon-Lise T
AU  - Normand SL
FAU - Shewan, Cynthia M
AU  - Shewan CM
FAU - O'Brien, Sean M
AU  - O'Brien SM
FAU - Peterson, Eric D
AU  - Peterson ED
FAU - Grover, Frederick L
AU  - Grover FL
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Ann Thorac Surg
JT  - The Annals of thoracic surgery
JID - 15030100R
SB  - IM
MH  - Benchmarking/*ethics/*trends
MH  - Cardiac Surgical Procedures/*ethics/*trends
MH  - Consumer Behavior
MH  - *Ethics, Medical
MH  - Feedback
MH  - Forecasting
MH  - Health Care Reform/ethics/trends
MH  - Health Status Indicators
MH  - Humans
MH  - National Practitioner Data Bank/*statistics & numerical data
MH  - Outcome Assessment, Health Care/*ethics/*trends
MH  - Personal Autonomy
MH  - Quality Improvement/ethics/trends
MH  - Quality Indicators, Health Care/*ethics/*trends
MH  - Social Responsibility
MH  - United States
EDAT- 2011/09/01 06:00
MHDA- 2011/10/25 06:00
CRDT- 2011/08/27 06:00
PHST- 2010/12/03 00:00 [received]
PHST- 2011/06/07 00:00 [revised]
PHST- 2011/06/09 00:00 [accepted]
PHST- 2011/08/27 06:00 [entrez]
PHST- 2011/09/01 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
AID - S0003-4975(11)01665-1 [pii]
AID - 10.1016/j.athoracsur.2011.06.100 [doi]
PST - ppublish
SO  - Ann Thorac Surg. 2011 Sep;92(3 Suppl):S2-11. doi:
      10.1016/j.athoracsur.2011.06.100.


PMID- 21857136
OWN - NLM
STAT- MEDLINE
DCOM- 20111209
LR  - 20110822
IS  - 1548-6869 (Electronic)
IS  - 1049-2089 (Linking)
VI  - 22
IP  - 3 Suppl
DP  - 2011 Aug
TI  - Hindsight, irony, and the ethical: a commentary on pandemics, social distancing, 
      and community mitigation strategies involving African American clergy.
PG  - 38-42
LID - 10.1353/hpu.2011.0100 [doi]
FAU - Scriven, Darryl
AU  - Scriven D
AD  - Tuskegee University National Center for Bioethics in Research and Health Care,
      Tuskegee, AL 36088, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Health Care Poor Underserved
JT  - Journal of health care for the poor and underserved
JID - 9103800
SB  - IM
MH  - *African Americans
MH  - *Clergy
MH  - Community-Institutional Relations/*economics
MH  - Financing, Government
MH  - Humans
MH  - Influenza, Human/epidemiology/*prevention & control
MH  - Pandemics/*prevention & control
MH  - *Social Isolation
MH  - United States/epidemiology
EDAT- 2011/09/01 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/08/23 06:00
PHST- 2011/08/23 06:00 [entrez]
PHST- 2011/09/01 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - S1548686911300058 [pii]
AID - 10.1353/hpu.2011.0100 [doi]
PST - ppublish
SO  - J Health Care Poor Underserved. 2011 Aug;22(3 Suppl):38-42. doi:
      10.1353/hpu.2011.0100.


PMID- 21857134
OWN - NLM
STAT- MEDLINE
DCOM- 20111209
LR  - 20110822
IS  - 1548-6869 (Electronic)
IS  - 1049-2089 (Linking)
VI  - 22
IP  - 3 Suppl
DP  - 2011 Aug
TI  - Preparing for an influenza pandemic: are some people more equal than others?
PG  - 19-35
LID - 10.1353/hpu.2011.0098 [doi]
AB  - CONTEXT: Planning for a severe influenza pandemic entails facing many substantive
      public health challenges, especially in the area of the distribution of
      insufficient supplies of materials and personnel. It is anticipated that
      rationing of health care resources will be required, thus demanding that choices 
      be made about which individuals should receive potentially life-saving care when 
      not all who can be saved can be served. EVIDENCE ACQUISITION: Most proposed
      triage and allocation plans have used medical inclusion and exclusion criteria to
      reduce this gap, but there will still be many more patients than resources. Thus,
      the potential to arbitrarily exclude groups of people on non-medical grounds in
      order to reduce relative scarcity could offer an attractive option. Can societies
      make reasoned anticipatory decisions to keep certain people from receiving
      influenza treatment in order to maximize the availability of care for other, more
      favored groups? RESULTS: In this paper, we argue that taking the fundamental
      moral equality of people seriously requires the inclusion of vulnerable, socially
      marginalized groups (such as illegal immigrants and incarcerated prisoners) in
      planning for a pandemic. While there may be a majoritarian justification for a
      priori discrimination against some groups of people on non-medical grounds, there
      are no morally defensible reasons to do so and many reasons not to engage in such
      behavior. CONCLUSIONS: Pandemic planners should resist attempts to institute
      either unsanctioned or authorized discrimination in resource allocation. Because 
      of their unique position in society, their ethical code and their essential role 
      in confronting a pandemic, physicians can (and should) defend egalitarianism in
      the allocation of health care resources in such a public health crisis and
      advocate and act against such exclusion were it to occur.
FAU - Rosoff, Philip M
AU  - Rosoff PM
AD  - Trent Center for Bioethics, Humanities and History of Medicine, Duke University
      Medical Center, Durham, NC 27710, USA. philip.rosoff@duke.edu
FAU - DeCamp, Matthew
AU  - DeCamp M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Health Care Poor Underserved
JT  - Journal of health care for the poor and underserved
JID - 9103800
SB  - IM
MH  - Disaster Planning/*organization & administration
MH  - Health Care Rationing/*ethics
MH  - Health Resources/supply & distribution
MH  - Humans
MH  - Influenza, Human/epidemiology/*prevention & control
MH  - Morals
MH  - Pandemics/*prevention & control
MH  - *Social Justice
MH  - United States/epidemiology
MH  - Vulnerable Populations
EDAT- 2011/09/01 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/08/23 06:00
PHST- 2011/08/23 06:00 [entrez]
PHST- 2011/09/01 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - S1548686911300034 [pii]
AID - 10.1353/hpu.2011.0098 [doi]
PST - ppublish
SO  - J Health Care Poor Underserved. 2011 Aug;22(3 Suppl):19-35. doi:
      10.1353/hpu.2011.0098.


PMID- 21857133
OWN - NLM
STAT- MEDLINE
DCOM- 20111209
LR  - 20211203
IS  - 1548-6869 (Electronic)
IS  - 1049-2089 (Linking)
VI  - 22
IP  - 3 Suppl
DP  - 2011 Aug
TI  - Emergency preparedness for a pandemic influenza: ethical challenges for black
      ministers and the public health community.
PG  - 14-8
LID - 10.1353/hpu.2011.0106 [doi]
FAU - Earl, Riggins R Jr
AU  - Earl RR Jr
AD  - Interdenominational Theological Center, 700 Martin Luther King Drive S.W.,
      Atlanta, GA 30314, USA. dukeearl@bellsouth.net
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Health Care Poor Underserved
JT  - Journal of health care for the poor and underserved
JID - 9103800
SB  - IM
MH  - Blacks
MH  - Clergy
MH  - *Community-Institutional Relations
MH  - Disaster Planning/*organization & administration
MH  - Humans
MH  - Influenza, Human/epidemiology/*prevention & control
MH  - Pandemics/*prevention & control
MH  - Public Health Practice/*ethics
MH  - Religion and Medicine
MH  - United States/epidemiology
EDAT- 2011/09/01 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/08/23 06:00
PHST- 2011/08/23 06:00 [entrez]
PHST- 2011/09/01 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - S1548686911300022 [pii]
AID - 10.1353/hpu.2011.0106 [doi]
PST - ppublish
SO  - J Health Care Poor Underserved. 2011 Aug;22(3 Suppl):14-8. doi:
      10.1353/hpu.2011.0106.


PMID- 31051856
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1876-7982 (Electronic)
IS  - 1876-7982 (Linking)
VI  - 42
IP  - 3
DP  - 2011 Sep
TI  - 10 Years Of Exposure to a Radiation Therapist Research Culture: Where Are We Now?
PG  - 106-112
LID - 10.1016/j.jmir.2011.04.004 [doi]
AB  - INTRODUCTION: Over the past 10 years, various programmatic changes have been
      implemented in our radiotherapy department to increase radiation therapist (RT)
      research activities. The aim of this qualitative study was to investigate the
      attitudes of RTs who have been working in a research-rich environment concerning 
      current research activities and the presence of enablers and inhibiters.
      MATERIALS AND METHODS: After obtaining research ethics approval, 5 focus groups
      and 6 interviews were conducted with a group of 30 RTs with varying levels of
      clinical experience, who were currently employed in our department. Data were
      audiotaped, transcribed, then analyzed independently by two investigators using a
      thematic approach. Emerging themes and categories were captured and evaluated.
      RESULTS: RTs most frequently engaged in research activities from a desire for
      patient service improvement and professional development. The main enablers
      identified were a system of process support and mentorship, and access to useful 
      research tools and databases (e.g., patient imaging databases). The most commonly
      noted inhibitor to research activities was securing protected research time.
      CONCLUSIONS: After 10 years of developing a research-rich environment, this study
      found that the majority of RTs were directly involved in some form of research,
      although the definition of research varied significantly. Enablers were
      identified as factors that support the practical aspects of RT research, rather
      than the gaining of theoretical knowledge. Although some of the inhibitors noted 
      are similar to those working in research-naive departments, they also add the
      practical considerations of balancing research and clinical practice. The
      practical nature of both the enablers and inhibitors found in this study support 
      the hypothesis that generating a research-rich environment for RTs has shifted
      their priorities from "thinking about research" to "doing research."
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Higgins, Jane
AU  - Higgins J
AD  - Radiation Medicine Program, Princess Margaret Hospital, Toronto, ON, Canada;
      Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada.
FAU - Davey, Caroline
AU  - Davey C
AD  - Radiation Medicine Program, Princess Margaret Hospital, Toronto, ON, Canada.
FAU - Li, Winnie
AU  - Li W
AD  - Radiation Medicine Program, Princess Margaret Hospital, Toronto, ON, Canada;
      Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada.
FAU - Chan, Kitty
AU  - Chan K
AD  - Radiation Medicine Program, Princess Margaret Hospital, Toronto, ON, Canada.
FAU - Wenz, Julie
AU  - Wenz J
AD  - Radiation Medicine Program, Princess Margaret Hospital, Toronto, ON, Canada.
FAU - Rosewall, Tara
AU  - Rosewall T
AD  - Radiation Medicine Program, Princess Margaret Hospital, Toronto, ON, Canada;
      Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada.
LA  - eng
PT  - Journal Article
DEP - 20110727
PL  - United States
TA  - J Med Imaging Radiat Sci
JT  - Journal of medical imaging and radiation sciences
JID - 101469694
EDAT- 2011/09/01 00:00
MHDA- 2011/09/01 00:01
CRDT- 2019/05/05 06:00
PHST- 2011/03/16 00:00 [received]
PHST- 2011/04/28 00:00 [accepted]
PHST- 2019/05/05 06:00 [entrez]
PHST- 2011/09/01 00:00 [pubmed]
PHST- 2011/09/01 00:01 [medline]
AID - S1939-8654(11)00032-4 [pii]
AID - 10.1016/j.jmir.2011.04.004 [doi]
PST - ppublish
SO  - J Med Imaging Radiat Sci. 2011 Sep;42(3):106-112. doi:
      10.1016/j.jmir.2011.04.004. Epub 2011 Jul 27.


PMID- 26257505
OWN - NLM
STAT- Publisher
LR  - 20191120
IS  - 1050-8422 (Print)
IS  - 1050-8422 (Linking)
VI  - 21
IP  - 5
DP  - 2011 Sep-Oct
TI  - Sensemaking Strategies for Ethical Decision-making.
PG  - 351-366
AB  - The current study uses a sensemaking model and thinking strategies identified in 
      earlier research to examine ethical decision-making. Using a sample of 163
      undergraduates, a low fidelity simulation approach is used to study the effects
      personal involvement (in causing the problem and personal involvement in
      experiencing the outcomes of the problem) could have on the use of cognitive
      reasoning strategies that have been shown to promote ethical decision-making. A
      mediated model is presented which suggests that environmental factors influence
      reasoning strategies, reasoning strategies influence sensemaking, and sensemaking
      in turn influences ethical decision-making. Findings were mixed but generally
      supported the hypothesized model. Interestingly, framing the outcomes of
      ethically charged situations in terms of more global organizational outcomes
      rather than personal outcomes was found to promote the use of pro-ethical
      cognitive reasoning strategies.
FAU - Caughron, Jay J
AU  - Caughron JJ
AD  - Radford University.
FAU - Antes, Alison L
AU  - Antes AL
AD  - Northern Kentucky University.
FAU - Stenmark, Cheryl K
AU  - Stenmark CK
AD  - San Angelo State University.
FAU - Thiel, Chaise E
AU  - Thiel CE
AD  - The University of Oklahoma.
FAU - Wang, Xiaoqian
AU  - Wang X
AD  - The University of Oklahoma.
FAU - Mumford, Michael D
AU  - Mumford MD
AD  - The University of Oklahoma.
LA  - eng
GR  - R01 NR010341/NR/NINR NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Ethics Behav
JT  - Ethics & behavior
JID - 9102086
PMC - PMC4527650
MID - NIHMS699223
OTO - NOTNLM
OT  - ethical decision-making
OT  - ethics
OT  - reasoning strategies
OT  - sensemaking
EDAT- 2011/09/01 00:00
MHDA- 2011/09/01 00:00
CRDT- 2015/08/11 06:00
PHST- 2015/08/11 06:00 [entrez]
PHST- 2011/09/01 00:00 [pubmed]
PHST- 2011/09/01 00:00 [medline]
AID - 10.1080/10508422.2011.604293 [doi]
PST - ppublish
SO  - Ethics Behav. 2011 Sep-Oct;21(5):351-366. doi: 10.1080/10508422.2011.604293.


PMID- 25812617
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150328
LR  - 20220210
IS  - 2005-727X (Print)
IS  - 2005-727X (Linking)
VI  - 23
IP  - 3
DP  - 2011 Sep
TI  - Case of misconduct of publication ethics: fabrication of of manuscript submission
      proof.
PG  - 225
LID - 10.3946/kjme.2011.23.3.225 [doi]
FAU - Kim, Sun
AU  - Kim S
LA  - eng
PT  - Journal Article
DEP - 20110930
PL  - Korea (South)
TA  - Korean J Med Educ
JT  - Korean journal of medical education
JID - 101503071
PMC - PMC8813532
EDAT- 2011/09/01 00:00
MHDA- 2011/09/01 00:01
CRDT- 2015/03/28 06:00
PHST- 2015/03/28 06:00 [entrez]
PHST- 2011/09/01 00:00 [pubmed]
PHST- 2011/09/01 00:01 [medline]
AID - kjme.2011.23.3.225 [pii]
AID - 10.3946/kjme.2011.23.3.225 [doi]
PST - ppublish
SO  - Korean J Med Educ. 2011 Sep;23(3):225. doi: 10.3946/kjme.2011.23.3.225. Epub 2011
      Sep 30.


PMID- 25812611
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150328
LR  - 20220210
IS  - 2005-727X (Print)
IS  - 2005-727X (Linking)
VI  - 23
IP  - 3
DP  - 2011 Sep
TI  - The Development Study of a Medical Ethics Education Program by Using Simple ISD
      Model.
PG  - 185-92
LID - 10.3946/kjme.2011.23.3.185 [doi]
AB  - PURPOSE: Simple instructional systems design (ISD) model is based on a fast
      development, usability test, and continuos feedback, which are necessary for
      educational program development in medical school. This study aims to figure out 
      the usability of Simple ISD model for a medical ethics education program by
      describing a developmental details of each phase and its evaluation results.
      METHODS: Research has been conducted in two steps. First, while researchers
      participated in the program development by using Simple ISD model, we collected
      empirical data of each development activities. Second, the developed program was 
      evaluated by students' web-based usability test, a 8-students' focus group
      interview and 5 faculty members' individual interviews in 4 domains; learning
      contents, instructional methods and strategies, achievement evaluation, and
      self-evaluation. RESULTS: Following the circular process of analysis, design,
      development, and usability test of Simple ISD model, a 10-week medical ethics
      program covering 9 instructional topics was developed. The average points of
      response on the developed medical ethics program in 2008 and 2009 are increased
      from 3.96 to 4.59 and 4.41, respectively. The prospects and limitations of the
      program are discussed. CONCLUSION: From a development study of the medical ethics
      program by using Simple ISD model, we could implement a more usable medical
      ethics program, and found 4 different usability of the Simple ISD model; the
      rapid development of educational program, program improvement by continuous
      feedback, faculty members' engagement in instructional design, and professional
      development of the faculty members.
FAU - Kim, Young Jon
AU  - Kim YJ
AD  - Department of Education, Seoul National University, Seoul, Korea.
FAU - Yoo, Hyoo Hyun
AU  - Yoo HH
AD  - Education Department, Chonbuk National University Medical School, Jeonju, Korea.
FAU - Joo, Chan Uhng
AU  - Joo CU
AD  - Department of Pediatrics, Chonbuk National University Medical School, Jeonju,
      Korea.
LA  - eng
PT  - Journal Article
DEP - 20110930
PL  - Korea (South)
TA  - Korean J Med Educ
JT  - Korean journal of medical education
JID - 101503071
PMC - PMC8813530
OTO - NOTNLM
OT  - Medical ethics
OT  - Program development
OT  - Simple instructional systems design
EDAT- 2011/09/01 00:00
MHDA- 2011/09/01 00:01
CRDT- 2015/03/28 06:00
PHST- 2011/04/18 00:00 [received]
PHST- 2011/07/13 00:00 [accepted]
PHST- 2015/03/28 06:00 [entrez]
PHST- 2011/09/01 00:00 [pubmed]
PHST- 2011/09/01 00:01 [medline]
AID - kjme.2011.23.3.185 [pii]
AID - 10.3946/kjme.2011.23.3.185 [doi]
PST - ppublish
SO  - Korean J Med Educ. 2011 Sep;23(3):185-92. doi: 10.3946/kjme.2011.23.3.185. Epub
      2011 Sep 30.


PMID- 25028628
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 2157-1724 (Print)
IS  - 2157-1716 (Linking)
VI  - 1
IP  - 3
DP  - 2011 Sep
TI  - The potential use of stem cells derived from human amniotic fluid in renal
      diseases.
PG  - 77-82
AB  - Amniotic fluid (AF) contains a variety of cell types derived from fetal tissues
      that can easily grow in culture. These cells can be obtained during amniocentesis
      for prenatal screening of fetal genetic diseases, usually performed during the
      second trimester of pregnancy. Of particular interest, some expanded
      sub-populations derived from AF cells are capable of extensive self-renewal and
      maintain prolonged undifferentiated proliferation, which are defining properties 
      of stem cells. These human AF stem cells (hAFSCs) exhibit multilineage potential 
      and can differentiate into the three germ layers. They have high proliferation
      rates and express mesenchymal and embryonic markers, but do not induce tumor
      formation. In this study, hAFSCs derived from amniocentesis performed at 16-20
      weeks of pregnancy were isolated, grown in culture, and characterized by flow
      cytometry and by their potential ability to differentiate into osteogenic,
      adipogenic, and chondrogenic lineages. After 4-7 passages, 5 x 10(5) hAFSCs were 
      inoculated under the kidney capsule of Wistar rats that were subjected to an
      experimental model of chronic renal disease, the 5/6 nephrectomy model (Nx).
      After 30 days, Nx rats treated with hAFSCs displayed significant reductions in
      blood pressure, proteinuria, macrophages, and alpha-smooth muscle actin
      expression compared with Nx animals. These preliminary results suggest that
      hAFSCs isolated and expanded from AF obtained by routine amniocentesis can
      promote renoprotection in the Nx model. Considering that the AF cells not used
      for fetal karyotyping are usually discarded, and that their use does not raise
      ethical issues, they may represent an alternative source of stem cells for cell
      therapy and regenerative medicine.
FAU - Noronha, Irene L
AU  - Noronha IL
AD  - Laboratory of Cellular, Genetic, and Molecular Nephrology, Faculty of Medicine,
      University of Sao Paulo , Sao Paulo, Brazil.
FAU - Cavaglieri, Rita C
AU  - Cavaglieri RC
AD  - Laboratory of Cellular, Genetic, and Molecular Nephrology, Faculty of Medicine,
      University of Sao Paulo , Sao Paulo, Brazil ; Laboratory of Genetic and Molecular
      Hematology, Faculty of Medicine, University of Sao Paulo , Sao Paulo, Brazil.
FAU - Janz, Felipe L
AU  - Janz FL
AD  - Laboratory of Genetic and Molecular Hematology, Faculty of Medicine, University
      of Sao Paulo , Sao Paulo, Brazil.
FAU - Duarte, Sergio A
AU  - Duarte SA
AD  - Department of Obstetrics and Gynecology, University of Sao Paulo , Sao Paulo,
      Brazil.
FAU - Lopes, Marco A B
AU  - Lopes MA
AD  - Department of Obstetrics and Gynecology, University of Sao Paulo , Sao Paulo,
      Brazil.
FAU - Zugaib, Marcelo
AU  - Zugaib M
AD  - Department of Obstetrics and Gynecology, University of Sao Paulo , Sao Paulo,
      Brazil.
FAU - Bydlowski, Sergio P
AU  - Bydlowski SP
AD  - Laboratory of Genetic and Molecular Hematology, Faculty of Medicine, University
      of Sao Paulo , Sao Paulo, Brazil.
LA  - eng
PT  - Review
PL  - United States
TA  - Kidney Int Suppl (2011)
JT  - Kidney international supplements
JID - 101562008
PMC - PMC4089735
OTO - NOTNLM
OT  - amniotic fluid stem cells
OT  - chronic kidney disease
OT  - mesenchymal stem cells
EDAT- 2011/09/01 00:00
MHDA- 2011/09/01 00:01
CRDT- 2014/07/17 06:00
PHST- 2014/07/17 06:00 [entrez]
PHST- 2011/09/01 00:00 [pubmed]
PHST- 2011/09/01 00:01 [medline]
AID - 10.1038/kisup.2011.18 [doi]
AID - S2157-1716(15)31017-0 [pii]
PST - ppublish
SO  - Kidney Int Suppl (2011). 2011 Sep;1(3):77-82. doi: 10.1038/kisup.2011.18.


PMID- 24850340
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140523
LR  - 20160511
IS  - 1947-5535 (Print)
IS  - 1947-5543 (Linking)
VI  - 9
IP  - 3
DP  - 2011 Sep
TI  - The human face of biobank networks for translational research.
PG  - 279-85
LID - 10.1089/bio.2011.0018 [doi]
AB  - The biobanking literature frequently addresses donor and societal issues
      surrounding biobanking, but the biobanker's perspective is rarely highlighted.
      While not comprehensive, this article offers an overview of the human aspects of 
      biobanking from the viewpoint of biobank personnel-from biobank formation,
      through the process, and in addressing post-biobanking issues. As every biobank
      and biobank network may differ, such factors may vary. Before biobanking can
      commence, the purpose of the biobank network must be defined, and buy-in achieved
      from many stakeholders. An attitude of trust and sharing is essential, as is good
      communication. Developing a biobank is time consuming and laborious. Forming a
      network requires significantly more time due to the need for cross-institutional 
      harmonization of policies, procedures, information technology considerations, and
      ethics. Circumstances may dictate whether development occurs top-down and/or
      bottom-up, as well as whether network management may be independent or by
      personnel from participating biobanks. Funding tends to be a prominent issue for 
      biobanks and networks alike. In particular, networks function optimally with some
      level of government support, particularly for personnel. Quality biospecimen
      collection involves meticulously documented coordination with a network of
      medical and nursing staff. Examining and sampling operative specimens requires
      timely collaboration between the surgical and pathology teams. "Catch rates" for 
      samples may be difficult to predict and may occur at a frequency less than
      anticipated due to factors related to the institution, staff, or specimen. These 
      factors may affect specimen quality, and have a downstream effect on competition 
      for specimens for research. Thus, release of samples requires a fair, carefully
      constructed sample access policy, usually incorporating an incentive for
      researchers, and an encouragement to form collaborations. Finally, the public and
      patient groups should aim to understand the benefits of a biobank network, so
      that patient care is improved through coordinated biobanking activity.
FAU - Meir, Karen
AU  - Meir K
AD  - 1 Department of Pathology, Hadassah-Hebrew University Medical Center , Jerusalem,
      Israel .
FAU - Gaffney, Eoin F
AU  - Gaffney EF
FAU - Simeon-Dubach, Daniel
AU  - Simeon-Dubach D
FAU - Ravid, Rivka
AU  - Ravid R
FAU - Watson, Peter H
AU  - Watson PH
FAU - Schacter, Brent
AU  - Schacter B
FAU - Morente And The Marble Arch International Working Group On Biobanking, Manuel M
AU  - Morente And The Marble Arch International Working Group On Biobanking MM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Biopreserv Biobank
JT  - Biopreservation and biobanking
JID - 101507284
EDAT- 2011/09/01 00:00
MHDA- 2011/09/01 00:01
CRDT- 2014/05/23 06:00
PHST- 2014/05/23 06:00 [entrez]
PHST- 2011/09/01 00:00 [pubmed]
PHST- 2011/09/01 00:01 [medline]
AID - 10.1089/bio.2011.0018 [doi]
PST - ppublish
SO  - Biopreserv Biobank. 2011 Sep;9(3):279-85. doi: 10.1089/bio.2011.0018.


PMID- 24850339
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140523
LR  - 20160511
IS  - 1947-5535 (Print)
IS  - 1947-5543 (Linking)
VI  - 9
IP  - 3
DP  - 2011 Sep
TI  - Collection, storage, and allogeneic use of cord blood: informed consent form used
      by the italian biobank network.
PG  - 273-8
LID - 10.1089/bio.2011.0013 [doi]
AB  - The National Blood Centre, the National Transplant Centre, and the Bioethics Unit
      of the Istituto Superiore di Sanita have compared the information leaflets and
      forms regarding the collection of informed consent used by each of the 18
      biobanks that comprise the Italian network. With a view to harmonize the
      provision of information to couples and the collection of informed consent within
      the Italian Cord Blood Network, the 3 organizations have prepared a standard
      information leaflet and informed consent form to be used for the collection,
      storage, and allogeneic use of cord blood. The proposed model can be a useful
      tool for the development of specific informed consent forms for cord blood
      banking that comprises the minimum information necessary to meet ethical and
      regulatory requirements also in other countries.
FAU - Petrini, Carlo
AU  - Petrini C
AD  - 1 Bioethics Unit, Office of the President, National Institutes of Health
      [Istituto Superiore di Sanita] , Rome, Italy .
FAU - Lombardini, Letizia
AU  - Lombardini L
FAU - Pupella, Simonetta
AU  - Pupella S
FAU - Nanni Costa, Alessandro
AU  - Nanni Costa A
FAU - Grazzini, Giuliano
AU  - Grazzini G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Biopreserv Biobank
JT  - Biopreservation and biobanking
JID - 101507284
EDAT- 2011/09/01 00:00
MHDA- 2011/09/01 00:01
CRDT- 2014/05/23 06:00
PHST- 2014/05/23 06:00 [entrez]
PHST- 2011/09/01 00:00 [pubmed]
PHST- 2011/09/01 00:01 [medline]
AID - 10.1089/bio.2011.0013 [doi]
PST - ppublish
SO  - Biopreserv Biobank. 2011 Sep;9(3):273-8. doi: 10.1089/bio.2011.0013.


PMID- 24761263
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 2156-5783 (Print)
IS  - 2156-5368 (Linking)
VI  - 1
IP  - 3
DP  - 2011 Sep
TI  - Alcohol and Caffeine: The Perfect Storm.
PG  - 153-162
AB  - Although it is widely believed that caffeine antagonizes the intoxicating effects
      of alcohol, the molecular mechanisms underlying their interaction are
      incompletely understood. It is known that both caffeine and alcohol alter
      adenosine neurotransmission, but the relationship is complex, and may be dose
      dependent. In this article, we review the available literature on combining
      caffeine and alcohol. Ethical constraints prohibit laboratory studies that would 
      mimic the high levels of alcohol intoxication achieved by many young people in
      real-world settings, with or without the addition of caffeine. We propose a
      possible neurochemical mechanism for the increase in alcohol consumption and
      alcohol-related consequences that have been observed in persons who
      simultaneously consume caffeine. Caffeine is a nonselective adenosine receptor
      antagonist. During acute alcohol intake, caffeine antagonizes the "unwanted"
      effects of alcohol by blocking the adenosine A1 receptors that mediate alcohol's 
      somnogenic and ataxic effects. The A1 receptor-mediated "unwanted" anxiogenic
      effects of caffeine may be ameliorated by alcohol-induced increase in the
      extracellular concentration of adenosine. Moreover, by means of interactions
      between adenosine A2A and dopamine D2 receptors, caffeine-mediated blockade of
      adenosine A2A receptors can potentiate the effects of alcohol-induced dopamine
      release. Chronic alcohol intake decreases adenosine tone. Caffeine may provide a 
      "treatment" for the withdrawal effects of alcohol by blocking the effects of
      upregulated A1 receptors. Finally, blockade of A2A receptors by caffeine may
      contribute to the reinforcing effects of alcohol.
FAU - Ferre, Sergi
AU  - Ferre S
AD  - CNS Receptor-Receptor Interactions Unit, National Institute on Drug Abuse ,
      Intramural Research Program, Department of Health and Human Services, Baltimore, 
      Maryland.
FAU - O'Brien, Mary Claire
AU  - O'Brien MC
AD  - Department of Emergency Medicine, Wake Forest School of Medicine , Winston-Salem,
      North Carolina. ; Department of Social Sciences & Health Policy, Wake Forest
      School of Medicine , Winston-Salem, North Carolina.
LA  - eng
PT  - Review
PL  - United States
TA  - J Caffeine Res
JT  - Journal of caffeine research
JID - 101565685
PMC - PMC3621334
EDAT- 2011/09/01 00:00
MHDA- 2011/09/01 00:01
CRDT- 2014/04/25 06:00
PHST- 2014/04/25 06:00 [entrez]
PHST- 2011/09/01 00:00 [pubmed]
PHST- 2011/09/01 00:01 [medline]
AID - 10.1089/jcr.2011.0017 [doi]
AID - 10.1089/jcr.2011.0017 [pii]
PST - ppublish
SO  - J Caffeine Res. 2011 Sep;1(3):153-162. doi: 10.1089/jcr.2011.0017.


PMID- 24501818
OWN - NLM
STAT- MEDLINE
DCOM- 20140401
LR  - 20191112
IS  - 0748-1187 (Print)
IS  - 0748-1187 (Linking)
VI  - 35
IP  - 8
DP  - 2011 Sep
TI  - Meaning-making through psychological autopsy interviews: the value of
      participating in qualitative research for those bereaved by suicide.
PG  - 685-710
AB  - Too often ethical boards delay or stop research projects with vulnerable
      populations, influenced by presumed rather than empirically documented
      vulnerability. The article investigates how participation is experienced by those
      bereaved by suicide. Experiences are divided into 3 groups: (a) overall positive 
      (62%), (b) unproblematic (10%), and (c) positive and painful (28%). The positive 
      experiences are linked to processes of meaning-making, gaining new insight, and a
      hope to help others. Objective factors concerning the gender of participants,
      their relationship to the deceased, the method of suicide, and time since loss
      were largely unrelated to their experience of the interview.
FAU - Dyregrov, Kari Madeleine
AU  - Dyregrov KM
AD  - Division of Psychological Health, Norwegian Institute of Public Health, Oslo,
      Norway. kari@krisepsyk.no
FAU - Dieserud, Gudrun
AU  - Dieserud G
AD  - Division of Psychological Health, Norwegian Institute of Public Health, Oslo,
      Norway.
FAU - Hjelmeland, Heidi Marie
AU  - Hjelmeland HM
AD  - Department of Social Work and Health Science, Norwegian University of Science and
      Technology, Trondheim, Norway.
FAU - Straiton, Melanie
AU  - Straiton M
AD  - Division of Psychological Health, Norwegian Institute of Public Health, Oslo,
      Norway.
FAU - Rasmussen, Mette Lyberg
AU  - Rasmussen ML
AD  - Division of Psychological Health, Norwegian Institute of Public Health, Oslo,
      Norway.
FAU - Knizek, Birthe Loa
AU  - Knizek BL
AD  - Department of Psychology, Norwegian University of Science and Technology,
      Trondheim, Norway.
FAU - Leenaars, Antoon Adrian
AU  - Leenaars AA
AD  - Division of Psychological Health, Norwegian Institute of Public Health, Oslo,
      Norway.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Death Stud
JT  - Death studies
JID - 8506890
MH  - *Adaptation, Psychological
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Awareness
MH  - *Bereavement
MH  - Consumer Behavior
MH  - Female
MH  - *Grief
MH  - Humans
MH  - *Interview, Psychological
MH  - Male
MH  - Mental Recall
MH  - Middle Aged
MH  - *Qualitative Research
MH  - Research Subjects/psychology
MH  - *Sense of Coherence
MH  - Suicide/*psychology
MH  - Young Adult
EDAT- 2011/09/01 00:00
MHDA- 2014/04/02 06:00
CRDT- 2014/02/08 06:00
PHST- 2014/02/08 06:00 [entrez]
PHST- 2011/09/01 00:00 [pubmed]
PHST- 2014/04/02 06:00 [medline]
AID - 10.1080/07481187.2011.553310 [doi]
PST - ppublish
SO  - Death Stud. 2011 Sep;35(8):685-710. doi: 10.1080/07481187.2011.553310.


PMID- 24159464
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131025
LR  - 20211021
IS  - 2210-9099 (Print)
IS  - 2210-9099 (Linking)
VI  - 2
IP  - 2
DP  - 2011 Sep
TI  - Registration of human embryonic stem cell lines: Korea, 2010.
PG  - 141-7
LID - 10.1016/j.phrp.2011.07.002 [doi]
AB  - In an effort to increase the credibility of human embryonic stem cell (hESC)
      lines established in Korea, obligatory registration was introduced by the
      Bioethics and Safety Act 2008, effective as of January 1, 2010. The DNA
      fingerprint, chromosome stability, expression of pluripotency markers, and
      contamination of mycoplasma of the submitted lines were analyzed by Korea Centers
      for Disease Control and Prevention (KCDC). The characterization data and ethical 
      aspects, such as informed consent for donation of surplus embryos, were reviewed 
      by a 10-member advisory review committee for stem cell registry. A total of 55
      domestic hESC lines were submitted for registration in 2010; among them 51 were
      registered. Among these submitted lines, 26 were additionally characterized by
      KCDC, while 25 lines previously characterized by the Ministry of Education,
      Science and Technology were not additionally analyzed by KCDC. Registration
      completed an oversight system for embryo research by registering the products of 
      licensed embryo research projects, making embryo research more transparent in
      Korea. Information about hESC lines is available at the website of the Korea Stem
      Cell Registry (kscr.nih.go.kr).
FAU - Lee, Ji-Yoon
AU  - Lee JY
AD  - Division of Life Science Research Management, Korea National Institute of Health,
      Osong, Korea.
FAU - Lee, Dae-Yeon
AU  - Lee DY
FAU - Choi, Young-Sil
AU  - Choi YS
FAU - Lee, Kyoung-Jae
AU  - Lee KJ
FAU - Kim, Yong-Ou
AU  - Kim YO
LA  - eng
PT  - Journal Article
DEP - 20110802
PL  - Korea (South)
TA  - Osong Public Health Res Perspect
JT  - Osong public health and research perspectives
JID - 101563309
PMC - PMC3766916
OTO - NOTNLM
OT  - embryo
OT  - human embryonic stem cell (hESC)
OT  - registry
EDAT- 2011/09/01 00:00
MHDA- 2011/09/01 00:01
CRDT- 2013/10/26 06:00
PHST- 2011/04/20 00:00 [received]
PHST- 2011/05/05 00:00 [revised]
PHST- 2011/05/10 00:00 [accepted]
PHST- 2013/10/26 06:00 [entrez]
PHST- 2011/09/01 00:00 [pubmed]
PHST- 2011/09/01 00:01 [medline]
AID - 10.1016/j.phrp.2011.07.002 [doi]
AID - S2210-9099(11)00028-2 [pii]
PST - ppublish
SO  - Osong Public Health Res Perspect. 2011 Sep;2(2):141-7. doi:
      10.1016/j.phrp.2011.07.002. Epub 2011 Aug 2.


PMID- 23905038
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130801
LR  - 20211021
IS  - 2239-9747 (Print)
IS  - 2239-9747 (Linking)
VI  - 1
DP  - 2011 Sep
TI  - Emergency contraception: an updated review.
PG  - 271-94
AB  - Emergency contraception is a common practice now. Many categories of drugs are
      marketed with modifications in dosage, in combination and even in the timing of
      administration. Recent re-analysis suggests that there is still no uniformity of 
      opinion on the actual mechanism of action and this has often fueled the ethical
      controversy. This review analyzes the most common emergency contraception drugs: 
      levonorgestrel, mifepristone and ulipristal acetate about their action
      underlining that the hormonal products, when used in emergency contraception,
      play different roles depending on the phase of the menstrual cycle during which
      they are administered.This review aims to examine rigorously the most accredited 
      literature to verify if a evidence-based uniformity of opinions has been achieved
      about the biological effects of hormones administered after the sexual
      intercourse.
FAU - Guida, M
AU  - Guida M
AD  - Department of Obstetrics & Gynecology, University of Salerno, Italy.
FAU - Marra, M L
AU  - Marra ML
FAU - Palatucci, V
AU  - Palatucci V
FAU - Pascale, R
AU  - Pascale R
FAU - Visconti, F
AU  - Visconti F
FAU - Zullo, F
AU  - Zullo F
LA  - eng
PT  - Journal Article
DEP - 20111017
PL  - Italy
TA  - Transl Med UniSa
JT  - Translational medicine @ UniSa
JID - 101588308
PMC - PMC3728844
OTO - NOTNLM
OT  - emergency contraception
OT  - levonorgestrel
OT  - mifepristone
OT  - ulipristal acetate
EDAT- 2011/09/01 00:00
MHDA- 2011/09/01 00:01
CRDT- 2013/08/02 06:00
PHST- 2013/08/02 06:00 [entrez]
PHST- 2011/09/01 00:00 [pubmed]
PHST- 2011/09/01 00:01 [medline]
PST - epublish
SO  - Transl Med UniSa. 2011 Oct 17;1:271-94. Print 2011 Sep.


PMID- 23550417
OWN - NLM
STAT- MEDLINE
DCOM- 20130801
LR  - 20181202
IS  - 0019-4832 (Print)
IS  - 0019-4832 (Linking)
VI  - 63
IP  - 5
DP  - 2011 Sep-Oct
TI  - A study of platelet aggregation in patients with acute myocardial infarction at
      presentation and after 48 hrs of initiating standard anti platelet therapy.
PG  - 409-13
AB  - AIMS & OBJECTIVES: Platelet aggregation is a key factor behind coronary artery
      disease. Various complications after an attack of acute coronary syndrome are
      often related to the platelet hyperactivity in the early hours following the
      event. There is a growing concern regarding aspirin & clopidogrel resistance,
      which has put the time-tested therapies under scrutiny. Time has come to address 
      the issue of platelet hyperactivity in the early hours & whether to individualize
      therapy and drug doses in different patients. MATERIALS & METHODS: We
      prospectively enrolled 41 patients with a diagnosis of acute myocardial
      infarction (AMI) between July 2009 and July 2010 admitted to the cardiology ward 
      and ICCU of Medical College, Kolkata, after fulfillment of inclusion & exclusion 
      criteria. The study was reviewed and approved by the Institutional Ethical
      Committee. Platelet Aggregation (PA) with 10 microM epinephrine, 2 microg/ml
      collagen and 10 microM ADP was performed with light transmittance aggregometry in
      all patients according to the standard protocol. Tests were done within 3 hours
      of sampling with platelet-rich plasma (PRP) by the turbidometric method in a
      2-channel aggregometer (Chrono-Log 490 Model, Chrono-Log Corp, Havertown, Pa).
      Aspirin & clopidogrel resistance were defined as per ACC/AHA guidelines. Platelet
      aggregation studies were done at presentation (zero hour) and 48 hours after
      instituting dual antiplatelet therapy in standard doses. RESULTS: Patients with
      first attack of AMI showed a high mean platelet aggregation at 0 hours of 77.4%
      +/- 18.8% with ADP, 77.5% +/- 26% with Epinephrine & 73.5% +/- 24.9% with
      Collagen. With all three agonists, the initial hyperactivity of platelets at 0
      hours was significantly higher among diabetics & obese. Though reduced,
      significant platelet hyperactivity remained at 48 hours after initiating standard
      antiplatelet therapy; 50.3% +/- 14.3% with ADP, 56.5% +/- 21.6% with epinephrine 
      & 38.4% +/- 22% with collagen. CONCLUSION: In the early hours after AMI there is 
      a fairly high degree of platelet aggregation. Even after 48 hours of standard
      antiplatelet therapy the platelet aggregation though reduced, still remains
      significantly high. Since recurrent ischemic episodes frequently occur in this
      vulnerable period, time has come to assess platelet aggregation status in high
      risk groups, if not in all patients of acute coronary syndrome during this period
      so that therapy may be individualized. Further researches are required in this
      area.
FAU - Guha, Santanu
AU  - Guha S
AD  - Dept. of Cardiology, Medical College, Kolkata, West Bengal, India.
      guhas55@hotmail.com
FAU - Mookerjee, Soura
AU  - Mookerjee S
FAU - Lahiri, P
AU  - Lahiri P
FAU - Mani, Sidhartha
AU  - Mani S
FAU - Saha, Jayanta
AU  - Saha J
FAU - Guha, Sharmila
AU  - Guha S
FAU - Majumdar, Debdatta
AU  - Majumdar D
FAU - Mandal, Md Miraj
AU  - Mandal MM
FAU - Bhattacharya, Raja
AU  - Bhattacharya R
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian Heart J
JT  - Indian heart journal
JID - 0374675
RN  - 0 (Platelet Aggregation Inhibitors)
RN  - A74586SNO7 (Clopidogrel)
RN  - OM90ZUW7M1 (Ticlopidine)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - Aged
MH  - Aspirin/*therapeutic use
MH  - Clopidogrel
MH  - Drug Resistance
MH  - Drug Therapy, Combination
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*drug therapy/physiopathology
MH  - Platelet Aggregation/*drug effects
MH  - Platelet Aggregation Inhibitors/*therapeutic use
MH  - Prospective Studies
MH  - Ticlopidine/*analogs & derivatives/therapeutic use
MH  - Time Factors
EDAT- 2011/09/01 00:00
MHDA- 2013/08/02 06:00
CRDT- 2013/04/05 06:00
PHST- 2013/04/05 06:00 [entrez]
PHST- 2011/09/01 00:00 [pubmed]
PHST- 2013/08/02 06:00 [medline]
PST - ppublish
SO  - Indian Heart J. 2011 Sep-Oct;63(5):409-13.


PMID- 23477274
OWN - NLM
STAT- MEDLINE
DCOM- 20130402
LR  - 20130312
IS  - 1029-4864 (Print)
IS  - 1029-4864 (Linking)
VI  - 66
IP  - 8
DP  - 2011 Sep
TI  - Dental ethics case 15. The importance of obtaining informed valid consent for
      surgery.
PG  - 394
FAU - Naidoo, S
AU  - Naidoo S
AD  - Department of Community Oral Health, University of the Western Cape, Private Bag 
      X1, Tygerberg, 7505. suenaidoo@uwc.ac.za
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - SADJ
JT  - SADJ : journal of the South African Dental Association = tydskrif van die
      Suid-Afrikaanse Tandheelkundige Vereniging
JID - 9812497
MH  - *Ethics, Dental
MH  - Female
MH  - Humans
MH  - Hypesthesia/*etiology
MH  - Informed Consent/*ethics
MH  - Mandible/surgery
MH  - Middle Aged
MH  - Oral Surgical Procedures/*adverse effects/ethics
MH  - Risk Management
MH  - Trigeminal Nerve Injuries/*etiology
EDAT- 2011/09/01 00:00
MHDA- 2013/04/03 06:00
CRDT- 2013/03/13 06:00
PHST- 2013/03/13 06:00 [entrez]
PHST- 2011/09/01 00:00 [pubmed]
PHST- 2013/04/03 06:00 [medline]
PST - ppublish
SO  - SADJ. 2011 Sep;66(8):394.


PMID- 23408794
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130215
LR  - 20211021
IS  - 0353-8109 (Print)
IS  - 0353-8109 (Linking)
VI  - 19
IP  - 3
DP  - 2011 Sep
TI  - Multiplane transesophageal echocardiography for multiclinical dilemmas.
PG  - 138-41
LID - 10.5455/aim.2011.19.138-141 [doi]
AB  - INTRODUCTION: Transesophageal echocardiography was introduced 4 decades ago. Its 
      use have had very limited clinical indication. Now it has become very useful
      clinical tool. Indications for its use are almost as indications for
      transthoracic echocardiography, especially to assess deeper cardiovascular
      structures. Transesophageal echocardiography is semi-invasive examination with
      small number of complications. AIM OF THE STUDY: To determine usefulness of
      transesophageal echocardiography in various cardiac conditions based in our
      experience. Also to encourage use of transesophageal echocardiography as reliable
      examination. METHODS: All of the patients signed a Term of Free Informed Consent,
      approved from Ethics Committee. We enrolled 425 patients who have done TEE in
      last 5 years (2006-2010) by authors. Medical history and Clinical evaluation was 
      carefully performed by expert cardiologists. Procedures were performed in two
      different centers using machines, PHILIPS iE33 and Siemens accuson CV 70, with
      equipment attached to a multi frequency 2.5 to 3.5 MHz for TTE and 7.0 MHz for
      TEE multiplane transducer. TEE were performed and images were obtained according 
      to the standard recommandations. RESULTS: The results were analyzed by a standard
      method of descriptive statistics using Pivot Table of Excel Office 2007. Results.
      We have analyzed 425 transesophageal echocardiography . The examination of the
      thoracic aorta in severe hypertension patients was conducted in 96 cases; atrial 
      fibrillation in 118; aortic dissection 49 cases, aortic stenosis was evaluated in
      28 cases; finding of source of emboli 36 cases; suspicion for aneurysm of the
      thoracic aorta in 14 cases, 11 cases with suspected endocarditis; the type of
      intervention for mitral valve was evaluated in 28 cases. Interatrial septum
      abnormalities 37 cases; and miscellaneous 18 cases. No minor or mayor
      complications happened. CONCLUSION: [corrected] Transesophageal echocardiography 
      can elucidate many dubious serious conditions immediately after it is performed. 
      So, we think that transesophageal echocardiography is very useful tool in
      everyday clinical use, almost without complications if it is done correctly.
FAU - Kamberi, Lulzim S
AU  - Kamberi LS
AD  - University Clinical Centre of Kosova, Prishtina, Kosova.
FAU - Gorani, Daut R
AU  - Gorani DR
FAU - Citaku, Hajdin R
AU  - Citaku HR
FAU - Selmani, Hamza H
AU  - Selmani HH
FAU - Beqiri, Arton I
AU  - Beqiri AI
FAU - Mustafai, Ardian I
AU  - Mustafai AI
LA  - eng
PT  - Journal Article
PL  - Bosnia and Herzegovina
TA  - Acta Inform Med
JT  - Acta informatica medica : AIM : journal of the Society for Medical Informatics of
      Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH
JID - 101147064
PMC - PMC3570941
OTO - NOTNLM
OT  - echocardiography.
OT  - transesophageal echocardiography
OT  - transthoracic echocardiography
EDAT- 2011/09/01 00:00
MHDA- 2011/09/01 00:01
CRDT- 2013/02/15 06:00
PHST- 2011/06/28 00:00 [received]
PHST- 2011/08/18 00:00 [accepted]
PHST- 2013/02/15 06:00 [entrez]
PHST- 2011/09/01 00:00 [pubmed]
PHST- 2011/09/01 00:01 [medline]
AID - 10.5455/aim.2011.19.138-141 [doi]
AID - AIM-19-138 [pii]
PST - ppublish
SO  - Acta Inform Med. 2011 Sep;19(3):138-41. doi: 10.5455/aim.2011.19.138-141.


PMID- 21876396
OWN - NLM
STAT- MEDLINE
DCOM- 20120124
LR  - 20110830
IS  - 1473-5695 (Electronic)
IS  - 0969-9546 (Linking)
VI  - 18
IP  - 5
DP  - 2011 Oct
TI  - Progress and publication ethics.
PG  - 243
LID - 10.1097/MEJ.0b013e32834bf447 [doi]
FAU - Graham, Colin A
AU  - Graham CA
LA  - eng
PT  - Editorial
PL  - England
TA  - Eur J Emerg Med
JT  - European journal of emergency medicine : official journal of the European Society
      for Emergency Medicine
JID - 9442482
SB  - IM
MH  - Emergency Medicine/ethics
MH  - *Ethics, Research
MH  - Humans
MH  - Informed Consent/ethics
MH  - Periodicals as Topic/*ethics
MH  - Publishing/*ethics
EDAT- 2011/08/31 06:00
MHDA- 2012/01/25 06:00
CRDT- 2011/08/31 06:00
PHST- 2011/08/31 06:00 [entrez]
PHST- 2011/08/31 06:00 [pubmed]
PHST- 2012/01/25 06:00 [medline]
AID - 10.1097/MEJ.0b013e32834bf447 [doi]
AID - 00063110-201110000-00001 [pii]
PST - ppublish
SO  - Eur J Emerg Med. 2011 Oct;18(5):243. doi: 10.1097/MEJ.0b013e32834bf447.


PMID- 21876209
OWN - NLM
STAT- MEDLINE
DCOM- 20120507
LR  - 20120111
IS  - 1049-7323 (Print)
IS  - 1049-7323 (Linking)
VI  - 22
IP  - 2
DP  - 2012 Feb
TI  - Unsolicited written narratives as a methodological genre in terminal illness:
      challenges and limitations.
PG  - 274-84
LID - 10.1177/1049732311420737 [doi]
AB  - Stories about illness have proven invaluable in helping health professionals
      understand illness experiences. Such narratives have traditionally been solicited
      by researchers through interviews and the collection of personal writings,
      including diaries. These approaches are, however, researcher driven; the impetus 
      for the creation of the story comes from the researcher and not the narrator. In 
      recent years there has been exponential growth in illness narratives created by
      individuals, of their own volition, and made available for others to read in
      print or as Internet accounts. We sought to determine whether it was possible to 
      identify such material for use as research data to explore the subject of living 
      with the terminal illness amyotrophic lateral sclerosis/motor neuron disease--the
      contention being that these accounts are narrator driven and therefore focus on
      issues of greatest importance to the affected person. We encountered and sought
      to overcome a number of methodological and ethical challenges, which is our focus
      here.
FAU - O'Brien, Mary R
AU  - O'Brien MR
AD  - Evidence-based Practice Research Centre, Faculty of Health, Edge Hill University,
      Ormskirk, Lancashire, United Kingdom. obrienm@edgehill.ac.uk
FAU - Clark, David
AU  - Clark D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110829
PL  - United States
TA  - Qual Health Res
JT  - Qualitative health research
JID - 9202144
MH  - Amyotrophic Lateral Sclerosis/psychology
MH  - Behavioral Research/*methods
MH  - Humans
MH  - *Internet
MH  - *Morals
MH  - Motor Neuron Disease/*psychology
MH  - Terminal Care/*psychology
MH  - Writing
EDAT- 2011/08/31 06:00
MHDA- 2012/05/09 06:00
CRDT- 2011/08/31 06:00
PHST- 2011/08/31 06:00 [entrez]
PHST- 2011/08/31 06:00 [pubmed]
PHST- 2012/05/09 06:00 [medline]
AID - 1049732311420737 [pii]
AID - 10.1177/1049732311420737 [doi]
PST - ppublish
SO  - Qual Health Res. 2012 Feb;22(2):274-84. doi: 10.1177/1049732311420737. Epub 2011 
      Aug 29.


PMID- 21876097
OWN - NLM
STAT- MEDLINE
DCOM- 20111101
LR  - 20190725
IS  - 1550-9613 (Electronic)
IS  - 0278-4297 (Linking)
VI  - 30
IP  - 9
DP  - 2011 Sep
TI  - Quantitative measurement for thyroid cancer characterization based on
      elastography.
PG  - 1259-66
AB  - OBJECTIVES: The purpose of this study was to evaluate color thyroid elastograms
      quantitatively and objectively and select more effective features to
      differentiate benign from malignant thyroid nodules. METHODS: The study was
      approved by the Ethics Committee of Harbin Medical University. A total of 125
      cases (56 malignant and 69 benign) were analyzed in this retrospective study. The
      original color thyroid elastograms were transferred from the red-green-blue color
      space to the hue-saturation-value color space. The elasticity information was
      represented by the hue component of color elastograms. The lesion regions were
      delineated by radiologists, and statistical and textural features were extracted.
      Then the most effective and reliable features among them were selected by using a
      minimum redundancy-maximum relevance algorithm. The selected features were input 
      to a support vector machine to differentiate benign from malignant thyroid
      nodules. RESULTS: The classification accuracy was 93.6% when the hard area ratio 
      and textural feature (energy) of the lesion region were used. The area under the 
      receiver operating characteristic curve for the hard area ratio was higher than
      that for the strain ratio (0.97 versus 0.87; P < .01), and the area under the
      curve for the hard area ratio was also higher than that for the color score (0.97
      versus 0.80; P < .001). The results also showed that the features were robust for
      lesion region delineation. CONCLUSIONS: The hard area ratio is an important and
      quantitative metric for elastograms. Quantitative analysis of elastograms using
      computer-aided diagnostic techniques can improve diagnostic accuracy.
FAU - Ding, Jianrui
AU  - Ding J
AD  - School of Computer Science and Technology, Harbin Institute of Technology,
      Harbin, China.
FAU - Cheng, Hengda
AU  - Cheng H
FAU - Ning, Chunping
AU  - Ning C
FAU - Huang, Jianhua
AU  - Huang J
FAU - Zhang, Yingtao
AU  - Zhang Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Ultrasound Med
JT  - Journal of ultrasound in medicine : official journal of the American Institute of
      Ultrasound in Medicine
JID - 8211547
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Algorithms
MH  - Color
MH  - Diagnosis, Computer-Assisted/methods
MH  - Elasticity Imaging Techniques/*methods
MH  - Female
MH  - Humans
MH  - Image Interpretation, Computer-Assisted/methods
MH  - Male
MH  - Middle Aged
MH  - ROC Curve
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - Thyroid Neoplasms/*diagnostic imaging/pathology
MH  - Thyroid Nodule/diagnostic imaging/pathology
EDAT- 2011/08/31 06:00
MHDA- 2011/11/02 06:00
CRDT- 2011/08/31 06:00
PHST- 2011/08/31 06:00 [entrez]
PHST- 2011/08/31 06:00 [pubmed]
PHST- 2011/11/02 06:00 [medline]
AID - 30/9/1259 [pii]
AID - 10.7863/jum.2011.30.9.1259 [doi]
PST - ppublish
SO  - J Ultrasound Med. 2011 Sep;30(9):1259-66. doi: 10.7863/jum.2011.30.9.1259.


PMID- 21875854
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20111020
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 261
IP  - 2
DP  - 2011 Nov
TI  - Regional homogeneity changes in heroin-dependent individuals: resting-state
      functional MR imaging study.
PG  - 551-9
LID - 10.1148/radiol.11102466 [doi]
AB  - PURPOSE: To identify heroin-related modulations of neural activity in the resting
      state in heroin-dependent individuals (HDIs) by using resting-state functional
      magnetic resonance (MR) imaging and a regional homogeneity method and to
      investigate whether these changes of neural activity can be related to duration
      of heroin use and to decision-making deficits in HDIs. MATERIALS AND METHODS:
      This prospective study was approved by the appropriate ethics committee, and
      written informed consent was obtained from each participant. Thirty-one HDIs
      receiving methadone-maintained treatment and 24 control subjects participated.
      Resting-state functional MR imaging was performed by using a gradient-echo
      echo-planar imaging sequence. Regional homogeneity was calculated by using
      software. Voxel-based analysis of the regional homogeneity maps between control
      and HDI groups was performed with two-sample t tests by using software.
      Statistical maps were set at P less than .05 and were corrected for multiple
      comparisons. The Iowa gambling task (IGT) was used to assess participant decision
      making during uncertainty. Abnormal clusters revealed by group comparison were
      extracted and correlated with behavioral performance at the IGT and with duration
      of heroin use. RESULTS: Regional homogeneity was diminished in the bilateral
      medial orbitofrontal cortex (OFC), bilateral dorsal medial thalamus, bilateral
      cuneus, and lingual gyrus in HDIs compared with control subjects. There were
      negative correlations between mean regional homogeneity in the medial OFC,
      bilateral cuneus, and lingual gyrus and duration of heroin use. There was a
      positive correlation between mean regional homogeneity in the medial OFC and
      performance level at the IGT. CONCLUSION: The present study reveals resting-state
      abnormalities in HDIs that may lead to further improvement of the understanding
      of the neural substrates of cognitive impairment in HDIs.
CI  - RSNA, 2011
FAU - Qiu, Ying-Wei
AU  - Qiu YW
AD  - Medical Imaging Centre, Nanfang Hospital, Southern Medical University, 1838
      Guangzhou Ave North, Guangzhou 510515, People's Republic of China.
FAU - Han, Lu-Jun
AU  - Han LJ
FAU - Lv, Xiao-Fei
AU  - Lv XF
FAU - Jiang, Gui-Hua
AU  - Jiang GH
FAU - Tian, Jun-Zhang
AU  - Tian JZ
FAU - Zhuo, Fu-Zhen
AU  - Zhuo FZ
FAU - Su, Huan-Huan
AU  - Su HH
FAU - Lin, Chu-Lan
AU  - Lin CL
FAU - Zhang, Xue-Lin
AU  - Zhang XL
LA  - eng
PT  - Journal Article
DEP - 20110826
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adult
MH  - Brain/*pathology
MH  - Brain Mapping/methods
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - Decision Making
MH  - Female
MH  - Heroin Dependence/*pathology
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Neural Pathways/*pathology
MH  - Prospective Studies
MH  - Statistics, Nonparametric
MH  - Task Performance and Analysis
EDAT- 2011/08/31 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/08/31 06:00
PHST- 2011/08/31 06:00 [entrez]
PHST- 2011/08/31 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - radiol.11102466 [pii]
AID - 10.1148/radiol.11102466 [doi]
PST - ppublish
SO  - Radiology. 2011 Nov;261(2):551-9. doi: 10.1148/radiol.11102466. Epub 2011 Aug 26.


PMID- 21875261
OWN - NLM
STAT- MEDLINE
DCOM- 20120529
LR  - 20170308
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Linking)
VI  - 12
IP  - 5
DP  - 2011
TI  - Practice and barriers toward breast self-examination among young Malaysian women.
PG  - 1173-8
AB  - INTRODUCTION: The etiology of breast cancer is still unknown and adequate primary
      prevention strategies or interventions are still not possible. Therefore, early
      detection remains the first priority and regular practice of breast
      self-examination (BSE) influences treatment, quality of life, survival, and
      prognosis of breast cancer patients. OBJECTIVES: The objective of this study was 
      to determine the practices and barriers towards breast self-examination among
      young Malaysian women. METHODOLOGY: Cross-sectional study was conducted among 251
      female students at the Management and Science University, Shah Alam, Selangor,
      Malaysia. Questionnaires were distributed at gathering places such as the
      university cafeteria, the university plaza, the Islamic center, and at the
      library. In addition, questionnaires were distributed in the lecture halls. The
      proposal of this study was approved by the Ethics and Research Committee of
      Management and Science University. Data was analysis using SPSS version 13,
      t-test was used to analyze the associated factors toward the practice of BSE.
      RESULTS: A total number of 251 students participated in this study. The majority 
      of them were older than 20 years old,of Malay racial origin, single and from
      urban areas (66.5%; 63.7%; 96%; 70.9% respectively). Regarding their lifestyle
      practices, the majority of participants do exercise, are non-smokers and do not
      drink alcohol (71.3%; 98.4%; 94.4% respectively). More than half of the study
      participants mentioned that they have practiced BSE (55.4%). Regarding the
      sources of information about BSE, the majority mentioned that radio and TV were
      their main sources of information (38.2%). Age, exercise and family history of
      cancer significantly influenced the practice of BSE (p = 0.045; p=0.002; p=0.017 
      respectively). Regarding the barriers to BSE, the majority who never practiced
      BSE mentioned that lack of knowledge, not having any symptoms, and being afraid
      of being diagnosed with breast cancer were the main barriers to practicing BSE
      (20.3%; 14.3%; 4.4% respectively). CONCLUSION: More than half of the participants
      practiced BSE. Age, exercise and family history of cancer significantly
      influenced the practice of the BSE. Lack of knowledge, not having any symptoms
      and being afraid of being diagnosed with breast cancer were the main barriers to 
      practicing BSE. There is an urgent need to develop a continuous awareness
      campaign among university students on the importance of performing BSE.
FAU - Al-Naggar, Redhwan Ahmed
AU  - Al-Naggar RA
AD  - Community Medicine Department, International Medical School, Management and
      Science University (MSU), Malaysia. radhwan888@yahoo.com
FAU - Al-Naggar, Dhekra Hamoud
AU  - Al-Naggar DH
FAU - Bobryshev, Yuri V
AU  - Bobryshev YV
FAU - Chen, Robert
AU  - Chen R
FAU - Assabri, Ali
AU  - Assabri A
LA  - eng
PT  - Journal Article
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
SB  - IM
MH  - Breast Neoplasms/*prevention & control
MH  - Breast Self-Examination/*statistics & numerical data/trends
MH  - Cross-Sectional Studies
MH  - Early Detection of Cancer/methods
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Malaysia
MH  - *Patient Compliance
MH  - Students
MH  - Surveys and Questionnaires
MH  - Universities
MH  - Young Adult
EDAT- 2011/08/31 06:00
MHDA- 2012/05/30 06:00
CRDT- 2011/08/31 06:00
PHST- 2011/08/31 06:00 [entrez]
PHST- 2011/08/31 06:00 [pubmed]
PHST- 2012/05/30 06:00 [medline]
PST - ppublish
SO  - Asian Pac J Cancer Prev. 2011;12(5):1173-8.


PMID- 21875170
OWN - NLM
STAT- MEDLINE
DCOM- 20120127
LR  - 20120626
IS  - 1935-990X (Electronic)
IS  - 0003-066X (Linking)
VI  - 66
IP  - 7
DP  - 2011 Oct
TI  - Nonrational processes in ethical decision making.
PG  - 614-23
LID - 10.1037/a0025215 [doi]
AB  - Most current ethical decision-making models provide a logical and reasoned
      process for making ethical judgments, but these models are empirically unproven
      and rely upon assumptions of rational, conscious, and quasilegal reasoning. Such 
      models predominate despite the fact that many nonrational factors influence
      ethical thought and behavior, including context, perceptions, relationships,
      emotions, and heuristics. For example, a large body of behavioral research has
      demonstrated the importance of automatic intuitive and affective processes in
      decision making and judgment. These processes profoundly affect human behavior
      and lead to systematic biases and departures from normative theories of
      rationality. Their influence represents an important but largely unrecognized
      component of ethical decision making. We selectively review this work; provide
      various illustrations; and make recommendations for scientists, trainers, and
      practitioners to aid them in integrating the understanding of nonrational
      processes with ethical decision making.
FAU - Rogerson, Mark D
AU  - Rogerson MD
AD  - mdrogerson@gmail.com
FAU - Gottlieb, Michael C
AU  - Gottlieb MC
FAU - Handelsman, Mitchell M
AU  - Handelsman MM
FAU - Knapp, Samuel
AU  - Knapp S
FAU - Younggren, Jeffrey
AU  - Younggren J
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Am Psychol
JT  - The American psychologist
JID - 0370521
SB  - IM
CIN - Am Psychol. 2012 May-Jun;67(4):324-5; discussion 325-6. PMID: 22583348
CIN - Am Psychol. 2012 May-Jun;67(4):325; discussion 325-6. PMID: 22583349
MH  - Decision Making/*ethics
MH  - Emotions/*ethics
MH  - Humans
MH  - Intuition/*ethics
MH  - Judgment/ethics
EDAT- 2011/08/31 06:00
MHDA- 2012/01/28 06:00
CRDT- 2011/08/31 06:00
PHST- 2011/08/31 06:00 [entrez]
PHST- 2011/08/31 06:00 [pubmed]
PHST- 2012/01/28 06:00 [medline]
AID - 2011-19198-001 [pii]
AID - 10.1037/a0025215 [doi]
PST - ppublish
SO  - Am Psychol. 2011 Oct;66(7):614-23. doi: 10.1037/a0025215.


PMID- 21874898
OWN - NLM
STAT- MEDLINE
DCOM- 20110913
LR  - 20191210
IS  - 1029-4864 (Print)
IS  - 1029-4864 (Linking)
VI  - 66
IP  - 3
DP  - 2011 Apr
TI  - Dental ethics case 10: advertising your field of practice after completing CPD
      course.
PG  - 139
FAU - Naidoo, S
AU  - Naidoo S
AD  - Department of Community Oral Health, University of the Western Cape, Tygerberg.
      suenaidoo@uwc.ac.za
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - SADJ
JT  - SADJ : journal of the South African Dental Association = tydskrif van die
      Suid-Afrikaanse Tandheelkundige Vereniging
JID - 9812497
MH  - Advertising/*ethics
MH  - Clinical Competence
MH  - Education, Dental, Continuing/*ethics
MH  - *Ethics, Dental
MH  - General Practice, Dental/*ethics
MH  - Humans
MH  - South Africa
MH  - Specialty Boards
EDAT- 2011/08/31 06:00
MHDA- 2011/09/14 06:00
CRDT- 2011/08/31 06:00
PHST- 2011/08/31 06:00 [entrez]
PHST- 2011/08/31 06:00 [pubmed]
PHST- 2011/09/14 06:00 [medline]
PST - ppublish
SO  - SADJ. 2011 Apr;66(3):139.


PMID- 21874695
OWN - NLM
STAT- MEDLINE
DCOM- 20110913
LR  - 20110830
IS  - 0164-9442 (Print)
IS  - 0164-9442 (Linking)
VI  - 102
IP  - 5
DP  - 2011 Jul-Aug
TI  - Why ethics?
PG  - 4
FAU - Brown, Richard L Jr
AU  - Brown RL Jr
LA  - eng
PT  - Editorial
PL  - United States
TA  - J Okla Dent Assoc
JT  - Journal - Oklahoma Dental Association
JID - 7905263
MH  - Dentist-Patient Relations/ethics
MH  - Ethics, Dental/*education
MH  - Humans
EDAT- 2011/08/31 06:00
MHDA- 2011/09/14 06:00
CRDT- 2011/08/31 06:00
PHST- 2011/08/31 06:00 [entrez]
PHST- 2011/08/31 06:00 [pubmed]
PHST- 2011/09/14 06:00 [medline]
PST - ppublish
SO  - J Okla Dent Assoc. 2011 Jul-Aug;102(5):4.


PMID- 21874031
OWN - NLM
STAT- MEDLINE
DCOM- 20111017
LR  - 20110829
IS  - 1546-1718 (Electronic)
IS  - 1061-4036 (Linking)
VI  - 43
IP  - 9
DP  - 2011 Aug 29
TI  - Learning to think continentally.
PG  - 817
LID - 10.1038/ng.933 [doi]
AB  - The US Department of Health and Human Services (DHHS) is proposing to enhance
      federal regulation intended to protect human research subjects, in particular to 
      increase measures aimed at security of personal data. Since the ethical review
      process is partially based on respect for people and their autonomy,
      harmonization of these rules will be a process of convincing individuals and
      their states to accept uniform standards that give enough privacy but do not lock
      away personal data from either research participants or researchers.
LA  - eng
PT  - Editorial
DEP - 20110829
PL  - United States
TA  - Nat Genet
JT  - Nature genetics
JID - 9216904
SB  - IM
MH  - *Guidelines as Topic
MH  - Human Experimentation/*ethics/*legislation & jurisprudence/standards
MH  - Humans
MH  - United States
MH  - *United States Dept. of Health and Human Services
EDAT- 2011/08/30 06:00
MHDA- 2011/10/18 06:00
CRDT- 2011/08/30 06:00
PHST- 2011/08/30 06:00 [entrez]
PHST- 2011/08/30 06:00 [pubmed]
PHST- 2011/10/18 06:00 [medline]
AID - ng.933 [pii]
AID - 10.1038/ng.933 [doi]
PST - epublish
SO  - Nat Genet. 2011 Aug 29;43(9):817. doi: 10.1038/ng.933.


PMID- 21873310
OWN - NLM
STAT- MEDLINE
DCOM- 20120312
LR  - 20111122
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 12
DP  - 2011 Dec
TI  - The ethics committee as ghost author.
PG  - 706
LID - 10.1136/medethics-2011-100120 [doi]
FAU - Shaw, David M
AU  - Shaw DM
LA  - eng
PT  - Editorial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110825
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Authorship
MH  - *Ethics Committees
MH  - Humans
MH  - Research Design/standards
EDAT- 2011/08/30 06:00
MHDA- 2012/03/13 06:00
CRDT- 2011/08/30 06:00
PHST- 2011/08/30 06:00 [entrez]
PHST- 2011/08/30 06:00 [pubmed]
PHST- 2012/03/13 06:00 [medline]
AID - medethics-2011-100120 [pii]
AID - 10.1136/medethics-2011-100120 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Dec;37(12):706. doi: 10.1136/medethics-2011-100120. Epub 2011 
      Aug 25.


PMID- 21873309
OWN - NLM
STAT- MEDLINE
DCOM- 20120322
LR  - 20111216
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 1
DP  - 2012 Jan
TI  - Diagnostic misconceptions? A closer look at clinical research on Alzheimer's
      disease.
PG  - 57-9
LID - 10.1136/medethics-2011-100026 [doi]
AB  - The current focus on early intervention trials in Alzheimer's disease research
      raises particular ethical issues. These arise out of problems of validating study
      results and translating them into general practice for one thing and out of
      unwanted effects of an uncertain diagnosis for diagnosed people for another. The 
      first addresses the demands of scientific research compared to those of medical
      practice, questioning how the medical value of clinical trials is evaluated. The 
      second relates the scientific and medical value of early intervention trials to
      the normative value of an uncertain diagnosis. Are people who are diagnosed with 
      a potential early form of AD in clinical studies patients proper-although they
      would not have been diagnosed with the given "disease" in non-research-oriented
      medical settings? The very problem of framing this question in terms of
      diagnostic misconceptions connects conceptual with ethical issues of research
      into preclinical stages of neurodegenerative diseases.
FAU - Kutschenko, Lara K
AU  - Kutschenko LK
AD  - Institute for History, Philosophy and Ethics of Medicine, University Medical
      Center Mainz, Am Pulverturm 13, Mainz, Germany. kutschel@uni-mainz.de
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110825
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Alzheimer Disease/*diagnosis/drug therapy
MH  - Biomedical Research/*ethics
MH  - Disease Progression
MH  - Early Medical Intervention
MH  - Ethics, Research
MH  - Humans
MH  - Patient Selection
MH  - Research Design
EDAT- 2011/08/30 06:00
MHDA- 2012/03/23 06:00
CRDT- 2011/08/30 06:00
PHST- 2011/08/30 06:00 [entrez]
PHST- 2011/08/30 06:00 [pubmed]
PHST- 2012/03/23 06:00 [medline]
AID - medethics-2011-100026 [pii]
AID - 10.1136/medethics-2011-100026 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Jan;38(1):57-9. doi: 10.1136/medethics-2011-100026. Epub 2011 
      Aug 25.


PMID- 21873308
OWN - NLM
STAT- MEDLINE
DCOM- 20120312
LR  - 20181201
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 12
DP  - 2011 Dec
TI  - Using human tissue: when do we need consent?
PG  - 759-61
LID - 10.1136/medethics-2011-100043 [doi]
AB  - Identifiable excess surgical tissue is an important resource for medical research
      but we have become overly restrictive about consent requirements. I suggest we
      devolve consent to ethics committees for ordinary research projects involving
      human tissue, retaining the requirement for explicit consent only for those
      sensitive research situations where there is significant risk of harm to
      individual interests in privacy.
FAU - Parker, Lisa
AU  - Parker L
AD  - School of Public Health and Community Medicine, University of New South Wales,
      Sydney, New South Wales 2052 Australia. lisa.parker@unsw.edu.au
LA  - eng
PT  - Journal Article
DEP - 20110825
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Biomedical Research/ethics
MH  - Ethics Committees, Research/ethics
MH  - *Ethics, Research
MH  - General Surgery
MH  - Human Experimentation
MH  - Humans
MH  - Informed Consent/*ethics/legislation & jurisprudence
MH  - Privacy
MH  - Tissue Banks/*statistics & numerical data
EDAT- 2011/08/30 06:00
MHDA- 2012/03/13 06:00
CRDT- 2011/08/30 06:00
PHST- 2011/08/30 06:00 [entrez]
PHST- 2011/08/30 06:00 [pubmed]
PHST- 2012/03/13 06:00 [medline]
AID - medethics-2011-100043 [pii]
AID - 10.1136/medethics-2011-100043 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Dec;37(12):759-61. doi: 10.1136/medethics-2011-100043. Epub
      2011 Aug 25.


PMID- 21873257
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 261
IP  - 2
DP  - 2011 Nov
TI  - Transcapsular arterial neovascularization after liver transplantation in
      pediatric patients indicates transplant failure.
PG  - 566-72
LID - 10.1148/radiol.11110138 [doi]
AB  - PURPOSE: To identify transcapsular arterial neovascularization with Doppler
      ultrasonography (US) in pediatric patients after liver transplantation and to
      assess the frequency of the finding, its underlying causes, and its relevance in 
      terms of clinical outcome. MATERIALS AND METHODS: The study was approved by the
      local ethics committee, with waived informed consent. All pediatric patients who 
      underwent liver transplantation between January 2000 and December 2003 were
      retrospectively evaluated. Patients were followed up until June 2008, by using a 
      predefined US protocol with prospective documentation. Of 182 consecutive liver
      transplantations performed in 162 patients (mean age, 4.5 years; range, 0.1-18.4 
      years) in this period, 25 patients with a total of 27 liver transplantations
      underwent US examinations conducted by multiple investigators and were primarily 
      excluded. Student t tests and chi(2) tests were performed where appropriate. The 
      Tarone-Ware test was used to compare transplant survival times. RESULTS:
      Transcapsular arterial neovascularization was noticed in 13 of 137 patients
      (9.5%) and in 13 of 155 liver transplants (8.4%). The mean time until arterial
      neovessels appeared was 157 days after liver transplantation (median, 97 days;
      range, 19-477 days). Arterial neovascularization was associated with pronounced
      transplant malperfusion and inflammatory changes (P < .001). Patients with
      transcapsular arterial neovascularization had a significantly shorter mean
      transplant survival time (1426.4 days +/- 244.5 [standard error], with 95%
      confidence interval: 947.23, 1905.23, vs 2526.4 days +/- 92.1, with 95%
      confidence interval: 2345.84, 2706.97; P = .008) and a higher retransplantation
      rate (53.8% vs 19.7%, P = .009). CONCLUSION: Transcapsular arterial
      neovascularization, detected with color Doppler US, occurred in 9.5% (13 of 137) 
      of pediatric patients and 8.4% (13 of 155) of liver transplants and was
      associated with underlying malperfusion and inflammation. The diagnosis of
      transcapsular arterial neovascularization was associated with reduced graft
      survival times and a high retransplantation rate. The negative prognostic value
      of the sign may assist in a strategy of organ allocation.
CI  - RSNA, 2011
FAU - Herrmann, Jochen
AU  - Herrmann J
AD  - Department of Pediatric Radiology, University Medical Center Hamburg-Eppendorf,
      Martinistrasse 52, 20246 Hamburg, Germany. j.herrmann@uke.de
FAU - Junge, Carl M
AU  - Junge CM
FAU - Burdelski, Martin
AU  - Burdelski M
FAU - Ganschow, Rainer
AU  - Ganschow R
FAU - Scheibner, Siegbert
AU  - Scheibner S
FAU - Petersen, Kay U
AU  - Petersen KU
FAU - Fischer, Lutz
AU  - Fischer L
FAU - Broering, Dieter C
AU  - Broering DC
FAU - Adam, Gerhard
AU  - Adam G
FAU - Helmke, Knut
AU  - Helmke K
LA  - eng
PT  - Journal Article
DEP - 20110824
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adolescent
MH  - Chi-Square Distribution
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - *Graft Rejection
MH  - Humans
MH  - Infant
MH  - *Liver Circulation
MH  - *Liver Transplantation
MH  - Male
MH  - Neovascularization, Pathologic/*diagnostic imaging
MH  - Prognosis
MH  - Retrospective Studies
MH  - Ultrasonography
EDAT- 2011/08/30 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/08/30 06:00
PHST- 2011/08/30 06:00 [entrez]
PHST- 2011/08/30 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - radiol.11110138 [pii]
AID - 10.1148/radiol.11110138 [doi]
PST - ppublish
SO  - Radiology. 2011 Nov;261(2):566-72. doi: 10.1148/radiol.11110138. Epub 2011 Aug
      24.


PMID- 21873254
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 261
IP  - 2
DP  - 2011 Nov
TI  - Stable angina pectoris: head-to-head comparison of prognostic value of cardiac CT
      and exercise testing.
PG  - 428-36
LID - 10.1148/radiol.11110744 [doi]
AB  - PURPOSE: To determine and compare the prognostic value of cardiac computed
      tomographic (CT) angiography, coronary calcium scoring, and exercise
      electrocardiography (ECG) in patients with chest pain who are suspected of having
      coronary artery disease (CAD). MATERIALS AND METHODS: This study complied with
      the Declaration of Helsinki, and the local ethics committee approved the study.
      Patients (n = 471) without known CAD underwent exercise ECG and dual-source CT at
      a rapid assessment outpatient chest pain clinic. Coronary calcification and the
      presence of 50% or greater coronary stenosis (in one or more vessels) were
      assessed with CT. Exercise ECG results were classified as normal, ischemic, or
      nondiagnostic. The primary outcome was a major adverse cardiac event (MACE),
      defined as cardiac death, nonfatal myocardial infarction, or unstable angina
      requiring hospitalization and revascularization beyond 6 months. Univariable and 
      multivariable Cox regression analysis was used to determine the prognostic
      values, while clinical impact was assessed with the net reclassification
      improvement metric. RESULTS: Follow-up was completed for 424 (90%) patients; the 
      mean duration of follow-up was 2.6 years. A total of 44 MACEs occurred in 30
      patients. Four of the MACEs were cardiac deaths and six were nonfatal myocardial 
      infarctions. The presence of coronary calcification (hazard ratio [HR], 8.22 [95%
      confidence interval {CI}: 1.96, 34.51]), obstructive CAD (HR, 6.22 [95% CI: 2.77,
      13.99]), and nondiagnostic stress test results (HR, 3.00 [95% CI: 1.26, 7.14])
      were univariable predictors of MACEs. In the multivariable model, CT angiography 
      findings (HR, 5.0 [95% CI: 1.7, 14.5]) and nondiagnostic exercise ECG results
      (HR, 2.9 [95% CI: 1.2, 7.0]) remained independent predictors of MACEs. CT
      angiography findings showed incremental value beyond clinical predictors and
      stress testing (global chi(2), 37.7 vs 13.7; P < .001), whereas coronary calcium 
      scores did not have further incremental value (global chi(2), 38.2 vs 37.7; P =
      .40). CONCLUSION: CT angiography findings are a strong predictor of future
      adverse events, showing incremental value over clinical predictors, stress
      testing, and coronary calcium scores. SUPPLEMENTAL MATERIAL:
      http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.11110744/-/DC1.
CI  - RSNA, 2011
FAU - Dedic, Admir
AU  - Dedic A
AD  - Department of Cardiology, Erasmus University Medical Centre, 's-Gravendijkwal
      230, PO Box 2040, 3000 CA Rotterdam, The Netherlands. a.dedic@erasmusmc.nl
FAU - Genders, Tessa S S
AU  - Genders TS
FAU - Ferket, Bart S
AU  - Ferket BS
FAU - Galema, Tjebbe W
AU  - Galema TW
FAU - Mollet, Nico R A
AU  - Mollet NR
FAU - Moelker, Adriaan
AU  - Moelker A
FAU - Hunink, M G Myriam
AU  - Hunink MG
FAU - de Feyter, Pim J
AU  - de Feyter PJ
FAU - Nieman, Koen
AU  - Nieman K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110824
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - 0 (Definity)
RN  - 0 (Fluorocarbons)
SB  - IM
CIN - Radiology. 2012 Jun;263(3):933-4; author reply 934. PMID: 22623702
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Angina Pectoris/*diagnostic imaging/*physiopathology
MH  - Calcinosis/diagnostic imaging/physiopathology
MH  - Chi-Square Distribution
MH  - Contrast Media
MH  - Coronary Angiography/*methods
MH  - Electrocardiography
MH  - *Exercise Test
MH  - Female
MH  - Fluorocarbons
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/diagnostic imaging/physiopathology
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Prospective Studies
MH  - Risk Factors
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2011/08/30 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/08/30 06:00
PHST- 2011/08/30 06:00 [entrez]
PHST- 2011/08/30 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - radiol.11110744 [pii]
AID - 10.1148/radiol.11110744 [doi]
PST - ppublish
SO  - Radiology. 2011 Nov;261(2):428-36. doi: 10.1148/radiol.11110744. Epub 2011 Aug
      24.


PMID- 21872793
OWN - NLM
STAT- MEDLINE
DCOM- 20111212
LR  - 20130715
IS  - 1532-2750 (Electronic)
IS  - 1098-612X (Linking)
VI  - 13
IP  - 9
DP  - 2011 Sep
TI  - Managing cats with cancer: An examination of ethical perspectives.
PG  - 661-71
LID - 10.1016/j.jfms.2011.07.019 [doi]
AB  - ETHICAL ISSUES: Caring for cancer patients presents many ethical issues for
      veterinarians and other veterinary health workers. The issues that most
      veterinarians think of relate to management of the patient when the owners'
      preferences for treatment do not appear to be in the animal's best interest, as
      well as concerns about toxicities and about costs of veterinary services
      (advanced imaging, surgery, radiation therapy and chemotherapy). While not
      limited to the veterinary profession, we are more often faced with dilemmas about
      the appropriateness of palliative care and decisions about euthanasia than our
      medical colleagues. Equally important are the ethics of not treating patients,
      and the integration of unproven and alternative strategies into conventional
      care. A separate ethical issue arises from investigational therapies and
      research. Less often considered, but nonetheless relevant, are the ethics of
      suboptimal evaluation (staging) of patients prior to treatment, or of not
      informing owners about all the options available. CLIENT COMMUNICATION: Ethical
      veterinary care is intertwined with good client communication. Without good
      communication, it is impossible, for example, to gain informed consent; and
      without informed consent, the ethics of cancer treatment are uncertain. GOAL:
      This article, which draws in part on published research, where stated, and
      otherwise on the author's personal experiences/opinions and those of veterinary
      colleagues, is intended to provoke further thought and discussion on the ethics
      of caring for our cancer patients.
CI  - Copyright (c) 2011 ISFM and AAFP. Published by Elsevier Ltd. All rights reserved.
FAU - Moore, Antony S
AU  - Moore AS
AD  - Veterinary Oncology Consultants. voc@vetoncologyconsults.com
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Feline Med Surg
JT  - Journal of feline medicine and surgery
JID - 100897329
SB  - IM
MH  - Animals
MH  - Carcinoma, Squamous Cell/therapy/veterinary
MH  - Cat Diseases/*therapy
MH  - Cats
MH  - Euthanasia, Animal/ethics
MH  - Female
MH  - Head and Neck Neoplasms/therapy/veterinary
MH  - Neoplasms/therapy/*veterinary
MH  - Palliative Care/ethics
MH  - Veterinary Medicine/ethics
EDAT- 2011/08/30 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/08/30 06:00
PHST- 2011/08/30 06:00 [entrez]
PHST- 2011/08/30 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - S1098-612X(11)00237-3 [pii]
AID - 10.1016/j.jfms.2011.07.019 [doi]
PST - ppublish
SO  - J Feline Med Surg. 2011 Sep;13(9):661-71. doi: 10.1016/j.jfms.2011.07.019.


PMID- 21872619
OWN - NLM
STAT- MEDLINE
DCOM- 20120119
LR  - 20110929
IS  - 1873-7528 (Electronic)
IS  - 0149-7634 (Linking)
VI  - 35
IP  - 9
DP  - 2011 Oct
TI  - The basic emotional circuits of mammalian brains: do animals have affective
      lives?
PG  - 1791-804
LID - 10.1016/j.neubiorev.2011.08.003 [doi]
AB  - The primal affects are intrinsic brain value systems that unconditionally and
      automatically inform animals how they are faring in survival. They serve an
      essential function in emotional learning. The positive affects index "comfort
      zones" that support survival, while negative affects inform animals of
      circumstances that may impair survival. Affective feelings come in several
      varieties, including sensory, homeostatic, and emotional (which I focus on here).
      Primary-process emotional feelings arise from ancient caudal and medial
      subcortical regions, and were among the first subjective experiences to exist on 
      the face of the earth. Without them, higher forms of conscious "awareness" may
      not have emerged in primate brain evolution. Because of homologous "instinctual" 
      neural infrastructures, we can utilize animal brain research to reveal the nature
      of primary-process human affects. Since all vertebrates appear to have some
      capacity for primal affective feelings, the implications for animal-welfare and
      how we ethically treat other animals are vast.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Panksepp, Jaak
AU  - Panksepp J
AD  - Department of VCAPP, College of Veterinary Medicine, Washington State University,
      Pullman, WA 99164-6520, USA. jpanksepp@vetmed.wsu.edu
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110819
PL  - United States
TA  - Neurosci Biobehav Rev
JT  - Neuroscience and biobehavioral reviews
JID - 7806090
SB  - IM
MH  - Affect/*physiology
MH  - Animals
MH  - Brain/*physiology
MH  - Cognition/physiology
MH  - Emotions/*physiology
MH  - Ethics, Research
MH  - Humans
MH  - Mammals/physiology
MH  - Nerve Net/*physiology
EDAT- 2011/08/30 06:00
MHDA- 2012/01/20 06:00
CRDT- 2011/08/30 06:00
PHST- 2010/10/22 00:00 [received]
PHST- 2011/07/23 00:00 [revised]
PHST- 2011/08/03 00:00 [accepted]
PHST- 2011/08/30 06:00 [entrez]
PHST- 2011/08/30 06:00 [pubmed]
PHST- 2012/01/20 06:00 [medline]
AID - S0149-7634(11)00149-7 [pii]
AID - 10.1016/j.neubiorev.2011.08.003 [doi]
PST - ppublish
SO  - Neurosci Biobehav Rev. 2011 Oct;35(9):1791-804. doi:
      10.1016/j.neubiorev.2011.08.003. Epub 2011 Aug 19.


PMID- 21871187
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20151119
IS  - 0156-5788 (Print)
IS  - 0156-5788 (Linking)
VI  - 35
IP  - 3
DP  - 2011 Aug
TI  - Resource allocation and economic evaluation in Australia's healthcare system.
PG  - 278-83
LID - 10.1071/AH10890 [doi]
AB  - OBJECTIVE: To explore dimensions and varieties of economic evaluations that
      healthcare decision-makers do or do not use. DESIGN: Web-based survey. SETTING
      AND PARTICIPANTS: A purposive sample of Australian healthcare decision-makers was
      recruited by direct invitation through email. All were invited to complete an
      online questionnaire derived from the EUROMET 2004 survey. RESULTS: A total of 91
      questionnaires were analysed. Almost all participants were involved in financial 
      resource allocations. Most commonly, participants based their decisions on
      patient needs, effectiveness of interventions, cost of interventions or overall
      budgetary effect, and policy directives. Evidence from cost-effectiveness
      analysis was used by half of the participants. Timing, ethical issues and lack of
      knowledge about economic evaluation were the most significant barriers to the use
      of economic evaluations in resource allocation decisions. Most participants
      reported being moderately to very familiar with the cost-effectiveness analysis. 
      There was a general impression that evidence from economic evaluations should
      play a larger role in the future. CONCLUSIONS: Evidence from health economic
      evaluations may provide valuable information in some decisions; however, at
      present, it is not central to many decisions. The study suggests that, for
      economic evaluation to be helpful in real-life policy decisions, it has to be
      placed into context - a context which is complex, political and often resistant
      to voluntary change.
FAU - Baghbanian, Abdolvahab
AU  - Baghbanian A
AD  - Zahedan University of Medical Sciences, Zahedan, Iran. abag2253@uni.sydney.edu.au
FAU - Hughes, Ian
AU  - Hughes I
FAU - Khavarpour, Freidoon A
AU  - Khavarpour FA
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Aust Health Rev
JT  - Australian health review : a publication of the Australian Hospital Association
JID - 8214381
MH  - Australia
MH  - Cost-Benefit Analysis/organization & administration
MH  - Delivery of Health Care/*organization & administration
MH  - Health Care Rationing/*economics
MH  - National Health Programs
MH  - Surveys and Questionnaires
EDAT- 2011/08/30 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/08/30 06:00
PHST- 2010/02/21 00:00 [received]
PHST- 2010/11/04 00:00 [accepted]
PHST- 2011/08/30 06:00 [entrez]
PHST- 2011/08/30 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - AH10890 [pii]
AID - 10.1071/AH10890 [doi]
PST - ppublish
SO  - Aust Health Rev. 2011 Aug;35(3):278-83. doi: 10.1071/AH10890.


PMID- 21871120
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1750-1164 (Electronic)
IS  - 1750-1164 (Linking)
VI  - 5
DP  - 2011 Aug 27
TI  - Stapler access and visibility in the deep pelvis: A comparative human cadaver
      study between a computerized right angle linear cutter versus a curved cutting
      stapler.
PG  - 7
LID - 10.1186/1750-1164-5-7 [doi]
AB  - PURPOSE: Distal rectal stapling is often challenging because of limited space and
      visibility. We compared two stapling devices in the distal rectum in a cadaver
      study: the iDrive right angle linear cutter (RALC) (Covidien, New Haven, CT) and 
      the CONTOUR(R) curved cutter (CC) (Ethicon Endo-Surgery, Cincinnati, OH).
      METHODS: Twelve male cadavers underwent pelvic dissection by 4 surgeons. After
      rectal mobilization as in a total mesorectal excision, the staplers were applied 
      to the rectum as deep as possible in both the coronal and sagittal positions. The
      distance from the pelvic floor was measured for each application. A questionnaire
      rated the visibility and access of the stapling devices. Measurements were taken 
      between pelvic landmarks to see what anatomic factors hinder the placement of a
      distal rectal stapler. RESULTS: The median (range) distance of the stapler from
      the pelvic floor in the coronal position for the RALC was 1.0 cm (0-4.0) vs. 2.0 
      cm (0-5.0) for the CC, p = 0.003. In the sagittal position, the median distance
      was 1.6 cm (0-3.5) for the RALC and 3.3 cm (0-5.0) for the CC, p < 0.0001. The
      RALC scored better than the CC in respect to: 1. interference by the symphysis
      pubis, 2. number of stapler readjustments, 3. ease of placement in the pelvis, 4.
      impediment of visibility, 5. ability to hold and retain tissue, 6. visibility
      rating, and 7. access in the pelvis. A shorter distance between the tip of the
      coccyx and the pubic symphysis correlated with a longer distance of the stapler
      from the pelvic floor (p = 0.002). CONCLUSIONS: The RALC is superior to the CC in
      terms of access, visibility, and ease of placement in the deep pelvis. This could
      provide important clinical benefit to both patient and surgeon during difficult
      rectal surgery.
FAU - Sonoda, Toyooki
AU  - Sonoda T
AD  - Department of Surgery, Weill Medical College of Cornell University, New York, NY,
      USA. tos2003@med.cornell.edu.
FAU - Verdeja, Juan Carlos
AU  - Verdeja JC
FAU - Rivadeneira, David E
AU  - Rivadeneira DE
LA  - eng
PT  - Journal Article
DEP - 20110827
PL  - England
TA  - Ann Surg Innov Res
JT  - Annals of surgical innovation and research
JID - 101266580
PMC - PMC3189175
EDAT- 2011/08/30 06:00
MHDA- 2011/08/30 06:01
CRDT- 2011/08/30 06:00
PHST- 2011/02/22 00:00 [received]
PHST- 2011/08/27 00:00 [accepted]
PHST- 2011/08/30 06:00 [entrez]
PHST- 2011/08/30 06:00 [pubmed]
PHST- 2011/08/30 06:01 [medline]
AID - 1750-1164-5-7 [pii]
AID - 10.1186/1750-1164-5-7 [doi]
PST - epublish
SO  - Ann Surg Innov Res. 2011 Aug 27;5:7. doi: 10.1186/1750-1164-5-7.


PMID- 21871104
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20220311
IS  - 1749-7922 (Electronic)
IS  - 1749-7922 (Linking)
VI  - 6
DP  - 2011 Aug 26
TI  - Clinical profile and outcome of surgical treatment of perforated peptic ulcers in
      Northwestern Tanzania: A tertiary hospital experience.
PG  - 31
LID - 10.1186/1749-7922-6-31 [doi]
AB  - BACKGROUND: Perforated peptic ulcer is a serious complication of peptic ulcers
      with potential risk of grave complications. There is paucity of published reports
      on perforated peptic ulcer disease in our local environment. This study was
      conducted to evaluate the clinical presentation, management and outcome of
      patients with peptic ulcer perforation in our setting and to identify predictors 
      of outcome of these patients. METHODS: This was a combined retrospective and
      prospective study of patients who were operated for perforated peptic ulcers at
      Bugando Medical Centre between April 2006 and March 2011. Data were collected
      using a pre-tested and coded questionnaire and analyzed using SPSS computer
      software version 15.0. Ethical approval to conduct the study was obtained from
      relevant authority before the commencement of the study. RESULTS: A total of 84
      patients were studied. Males outnumbered females by a ratio of 1.3: 1. Their
      median age was 28 years and the modal age group was 21-30 years. The median
      duration of illness was 5.8 days. The majority of patients (69.0%) had no
      previous history of treatment for peptic ulcer disease. The use of non-steroidal 
      anti-inflammatory drugs, alcohol and smoking was reported in 10.7%, 85.7% and
      64.3% respectively. Eight (9.5%) patients were HIV positive with a median CD4
      count of 220 cells/mul. Most perforations were located on the duodenum {90.4%)
      with the duodenal to gastric ulcers ratio of 12.7: 1. Graham's omental patch
      (Graham's omentopexy) of the perforations was performed in 83.3% of cases.
      Complication and mortality rates were 29.8% and 10.7% respectively. The factors
      significantly related to complications were premorbid illness, HIV status, CD 4
      count < 200 cells/mul, treatment delay and acute perforation (P < 0.001).
      Mortality rate was high in patients who had age >/= 40 years, delayed
      presentation (>24 hrs), shock at admission (systolic BP < 90 mmHg), HIV
      positivity, low CD4 count (<200 cells/mul), gastric ulcers, concomitant diseases 
      and presence of complications (P < 0.001). The median overall length of hospital 
      stay was 14 days. Excellent results using Visick's grading system were obtained
      in 82.6% of surviving patients. CONCLUSION: Perforation of peptic ulcer remains a
      frequent clinical problem in our environment predominantly affecting young males 
      not known to suffer from PUD. Simple closure with omental patch followed by
      Helicobacter pylori eradication was effective with excellent results in majority 
      of survivors despite patients' late presentation in our center.
FAU - Chalya, Phillipo L
AU  - Chalya PL
AD  - Department of Surgery, Weill-Bugando University College of Health Sciences,
      Mwanza, Tanzania.
FAU - Mabula, Joseph B
AU  - Mabula JB
AD  - Department of Surgery, Weill-Bugando University College of Health Sciences,
      Mwanza, Tanzania.
FAU - Koy, Mheta
AU  - Koy M
AD  - Department of Internal Medicine, Weill-Bugando University College of Health
      Sciences, Mwanza, Tanzania.
FAU - Mchembe, Mabula D
AU  - Mchembe MD
AD  - Department of Surgery, Muhimbili University of Health and Allied Sciences, Dar Es
      Salaam, Tanzania.
FAU - Jaka, Hyasinta M
AU  - Jaka HM
AD  - Department of Internal Medicine, Weill-Bugando University College of Health
      Sciences, Mwanza, Tanzania.
FAU - Kabangila, Rodrick
AU  - Kabangila R
AD  - Department of Internal Medicine, Weill-Bugando University College of Health
      Sciences, Mwanza, Tanzania.
FAU - Chandika, Alphonce B
AU  - Chandika AB
AD  - Department of Surgery, Weill-Bugando University College of Health Sciences,
      Mwanza, Tanzania.
FAU - Gilyoma, Japhet M
AU  - Gilyoma JM
AD  - Department of Surgery, Weill-Bugando University College of Health Sciences,
      Mwanza, Tanzania.
LA  - eng
PT  - Journal Article
DEP - 20110826
PL  - England
TA  - World J Emerg Surg
JT  - World journal of emergency surgery : WJES
JID - 101266603
PMC - PMC3179712
EDAT- 2011/08/30 06:00
MHDA- 2011/08/30 06:01
CRDT- 2011/08/30 06:00
PHST- 2011/07/10 00:00 [received]
PHST- 2011/08/26 00:00 [accepted]
PHST- 2011/08/30 06:00 [entrez]
PHST- 2011/08/30 06:00 [pubmed]
PHST- 2011/08/30 06:01 [medline]
AID - 1749-7922-6-31 [pii]
AID - 10.1186/1749-7922-6-31 [doi]
PST - epublish
SO  - World J Emerg Surg. 2011 Aug 26;6:31. doi: 10.1186/1749-7922-6-31.


PMID- 21871090
OWN - NLM
STAT- MEDLINE
DCOM- 20111202
LR  - 20211020
IS  - 1743-422X (Electronic)
IS  - 1743-422X (Linking)
VI  - 8
DP  - 2011 Aug 26
TI  - Prevalence and resistance mutations of non-B HIV-1 subtypes among immigrants in
      Southern Spain along the decade 2000-2010.
PG  - 416
LID - 10.1186/1743-422X-8-416 [doi]
AB  - BACKGROUND: Most of the non-B HIV-1 subtypes are predominant in Sub-Saharan
      Africa and India although they have been found worldwide. In the last decade,
      immigration from these areas has increased considerably in Spain. The objective
      of this study was to evaluate the prevalence of non-B subtypes circulating in a
      cohort of HIV-1-infected immigrants in Seville, Southern Spain and to identify
      drug resistance-associated mutations. METHODS: Complete protease and first 220
      codons of the reverse transcriptase coding regions were amplified and sequenced
      by population sequencing. HIV-1 subtypes were determined using Stanford
      University Drug Resistance Database, and phylogenetic analysis was performed
      comparing multiple reported sequences. Drug resistance mutations were defined
      according to the International AIDS Society-USA. RESULTS: From 2000 to 2010 a
      total of 1,089 newly diagnosed HIV-1-infected patients were enrolled in our
      cohort. Of these, 121 were immigrants, of which 98 had ethical approval and
      informed consent to include in our study. Twenty-nine immigrants (29/98, 29.6%)
      were infected with non-B subtypes, of which 15/29 (51.7%) were CRF02-AG, mostly
      from Sub-Saharan Africa, and 2/29 (6.9%) were CRF01-AE from Eastern Europe. A, C,
      F, J and G subtypes from Eastern Europe, Central-South America and Sub-Saharan
      Africa were also present. Some others harboured recombinant forms
      CRF02-AG/CRF01-AE, CRF2-AG/G and F/B, B/C, and K/G, in PR and RT-coding regions. 
      Patients infected with non-B subtypes showed a high frequency of minor protease
      inhibitor resistance mutations, M36I, L63P, and K20R/I. Only one patient,
      CRF02_AG, showed major resistance mutation L90M. Major RT inhibitor resistance
      mutations K70R and A98G were present in one patient with subtype G, L100I in one 
      patient with CRF01_AE, and K103N in another patient with CRF01_AE. Three patients
      had other mutations such as V118I, E138A and V90I. CONCLUSIONS: The circulation
      of non-B subtypes has significantly increased in Southern Spain during the last
      decade, with 29.6% prevalence, in association with demographic changes among
      immigrants. This could be an issue in the treatment and management of these
      patients. Resistance mutations have been detected in these patients with a
      prevalence of 7% among treatment-naive patients compared with the 21% detected
      among patients under HAART or during treatment interruption.
FAU - de Felipe, Beatriz
AU  - de Felipe B
AD  - Laboratory of Immunovirology, Infectious Diseases Service, Instituto Ramon y
      Cajal de Investigaciones Cientificas (IRYCIS), Hospital Universitario Ramon y
      Cajal, Madrid, Spain.
FAU - Perez-Romero, Pilar
AU  - Perez-Romero P
FAU - Abad-Fernandez, Maria
AU  - Abad-Fernandez M
FAU - Fernandez-Cuenca, Felipe
AU  - Fernandez-Cuenca F
FAU - Martinez-Fernandez, Francisco J
AU  - Martinez-Fernandez FJ
FAU - Trastoy, Monica
AU  - Trastoy M
FAU - Mata, Rosario Del Carmen
AU  - Mata Rdel C
FAU - Lopez-Cortes, Luis F
AU  - Lopez-Cortes LF
FAU - Leal, Manuel
AU  - Leal M
FAU - Viciana, Pompeyo
AU  - Viciana P
FAU - Vallejo, Alejandro
AU  - Vallejo A
LA  - eng
SI  - GENBANK/JF338626
SI  - GENBANK/JF338627
SI  - GENBANK/JF338628
SI  - GENBANK/JF338629
SI  - GENBANK/JF338630
SI  - GENBANK/JF338631
SI  - GENBANK/JF338632
SI  - GENBANK/JF338633
SI  - GENBANK/JF338634
SI  - GENBANK/JF338635
SI  - GENBANK/JF338636
SI  - GENBANK/JF338637
SI  - GENBANK/JF338638
SI  - GENBANK/JF338639
SI  - GENBANK/JF338640
SI  - GENBANK/JF338641
SI  - GENBANK/JF338642
SI  - GENBANK/JF338643
SI  - GENBANK/JF338644
SI  - GENBANK/JF338645
SI  - GENBANK/JF338646
SI  - GENBANK/JF338647
SI  - GENBANK/JF338648
SI  - GENBANK/JF338649
SI  - GENBANK/JF338650
SI  - GENBANK/JF338651
SI  - GENBANK/JF338652
SI  - GENBANK/JF338653
SI  - GENBANK/JF338654
SI  - GENBANK/JF338655
SI  - GENBANK/JF338656
SI  - GENBANK/JF338657
SI  - GENBANK/JF338658
SI  - GENBANK/JF338659
SI  - GENBANK/JF338660
SI  - GENBANK/JF338661
SI  - GENBANK/JF338662
SI  - GENBANK/JF338663
SI  - GENBANK/JF338664
SI  - GENBANK/JF338665
SI  - GENBANK/JF338666
SI  - GENBANK/JF338667
SI  - GENBANK/JF338668
SI  - GENBANK/JF338669
SI  - GENBANK/JF338670
SI  - GENBANK/JF338671
SI  - GENBANK/JF338672
SI  - GENBANK/JF338673
SI  - GENBANK/JF338674
SI  - GENBANK/JF338675
SI  - GENBANK/JF338676
SI  - GENBANK/JF338677
SI  - GENBANK/JF338678
SI  - GENBANK/JF338679
SI  - GENBANK/JF338680
SI  - GENBANK/JF338681
SI  - GENBANK/JF338682
SI  - GENBANK/JF338683
SI  - GENBANK/JF338684
SI  - GENBANK/JF338685
SI  - GENBANK/JF338686
SI  - GENBANK/JF338687
SI  - GENBANK/JF338688
SI  - GENBANK/JF338689
SI  - GENBANK/JF338690
SI  - GENBANK/JF338691
SI  - GENBANK/JF338692
SI  - GENBANK/JF338693
SI  - GENBANK/JF338694
SI  - GENBANK/JF338695
SI  - GENBANK/JF338696
SI  - GENBANK/JF338697
SI  - GENBANK/JF338698
SI  - GENBANK/JF338699
SI  - GENBANK/JF338700
SI  - GENBANK/JF338701
SI  - GENBANK/JF338702
SI  - GENBANK/JF338703
SI  - GENBANK/JF338704
SI  - GENBANK/JF338705
SI  - GENBANK/JF338706
SI  - GENBANK/JF338707
SI  - GENBANK/JF338708
SI  - GENBANK/JF338709
SI  - GENBANK/JF338710
SI  - GENBANK/JF338711
SI  - GENBANK/JF338712
SI  - GENBANK/JF338713
SI  - GENBANK/JF338714
SI  - GENBANK/JF338715
SI  - GENBANK/JF338716
SI  - GENBANK/JF338717
SI  - GENBANK/JF338718
SI  - GENBANK/JF338719
SI  - GENBANK/JF338720
SI  - GENBANK/JF338721
SI  - GENBANK/JF338722
SI  - GENBANK/JF338723
SI  - GENBANK/JF338724
SI  - GENBANK/JF338725
SI  - GENBANK/JF338726
SI  - GENBANK/JF338727
SI  - GENBANK/JF338728
SI  - GENBANK/JF338729
SI  - GENBANK/JF338730
SI  - GENBANK/JF338731
SI  - GENBANK/JF338732
SI  - GENBANK/JF338733
SI  - GENBANK/JF338734
SI  - GENBANK/JF338735
SI  - GENBANK/JF338736
SI  - GENBANK/JF338737
SI  - GENBANK/JF338738
SI  - GENBANK/JF338739
SI  - GENBANK/JF338740
SI  - GENBANK/JF338741
SI  - GENBANK/JF338742
SI  - GENBANK/JF338743
SI  - GENBANK/JF338744
SI  - GENBANK/JF338745
SI  - GENBANK/JF338746
SI  - GENBANK/JF338747
SI  - GENBANK/JF338748
SI  - GENBANK/JF338749
SI  - GENBANK/JF338750
SI  - GENBANK/JF338751
SI  - GENBANK/JF338752
SI  - GENBANK/JF338753
SI  - GENBANK/JF338754
SI  - GENBANK/JF338755
SI  - GENBANK/JF338756
SI  - GENBANK/JF338757
SI  - GENBANK/JF338758
SI  - GENBANK/JF338759
SI  - GENBANK/JF338760
SI  - GENBANK/JF338761
SI  - GENBANK/JF338762
SI  - GENBANK/JF338763
SI  - GENBANK/JF338764
SI  - GENBANK/JF338765
SI  - GENBANK/JF338766
SI  - GENBANK/JF338767
SI  - GENBANK/JF338768
SI  - GENBANK/JF338769
SI  - GENBANK/JF338770
SI  - GENBANK/JF338771
SI  - GENBANK/JF338772
SI  - GENBANK/JF338773
SI  - GENBANK/JF338774
SI  - GENBANK/JF338775
SI  - GENBANK/JF338776
SI  - GENBANK/JF338777
SI  - GENBANK/JF338778
SI  - GENBANK/JF338779
SI  - GENBANK/JF338780
SI  - GENBANK/JF338781
SI  - GENBANK/JF338782
SI  - GENBANK/JF338783
SI  - GENBANK/JF338784
SI  - GENBANK/JF338785
SI  - GENBANK/JF338786
SI  - GENBANK/JF338787
SI  - GENBANK/JF338788
SI  - GENBANK/JF338789
SI  - GENBANK/JF338790
SI  - GENBANK/JF338791
SI  - GENBANK/JF338792
SI  - GENBANK/JF338793
SI  - GENBANK/JF338794
SI  - GENBANK/JF338795
SI  - GENBANK/JF338796
SI  - GENBANK/JF338797
SI  - GENBANK/JF338798
SI  - GENBANK/JF338799
SI  - GENBANK/JF338800
SI  - GENBANK/JF338801
SI  - GENBANK/JF338802
SI  - GENBANK/JF338803
SI  - GENBANK/JF338804
SI  - GENBANK/JF338805
SI  - GENBANK/JF338806
SI  - GENBANK/JF338807
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110826
PL  - England
TA  - Virol J
JT  - Virology journal
JID - 101231645
RN  - 0 (Anti-HIV Agents)
RN  - EC 2.7.7.- (reverse transcriptase, Human immunodeficiency virus 1)
RN  - EC 2.7.7.49 (HIV Reverse Transcriptase)
RN  - EC 3.4.23.- (HIV Protease)
RN  - EC 3.4.23.- (p16 protease, Human immunodeficiency virus 1)
SB  - IM
MH  - Adult
MH  - Anti-HIV Agents/pharmacology
MH  - Cluster Analysis
MH  - *Drug Resistance, Viral
MH  - *Emigrants and Immigrants
MH  - Female
MH  - Genotype
MH  - HIV Infections/*epidemiology/virology
MH  - HIV Protease/*genetics
MH  - HIV Reverse Transcriptase/*genetics
MH  - HIV-1/*drug effects/isolation & purification
MH  - Humans
MH  - Male
MH  - Molecular Sequence Data
MH  - *Mutation, Missense
MH  - Phylogeny
MH  - Prevalence
MH  - Sequence Analysis, DNA
MH  - Spain/epidemiology
PMC - PMC3170306
EDAT- 2011/08/30 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/08/30 06:00
PHST- 2011/06/14 00:00 [received]
PHST- 2011/08/26 00:00 [accepted]
PHST- 2011/08/30 06:00 [entrez]
PHST- 2011/08/30 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 1743-422X-8-416 [pii]
AID - 10.1186/1743-422X-8-416 [doi]
PST - epublish
SO  - Virol J. 2011 Aug 26;8:416. doi: 10.1186/1743-422X-8-416.


PMID- 21871049
OWN - NLM
STAT- MEDLINE
DCOM- 20120119
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 39
IP  - 3
DP  - 2011 Fall
TI  - Paying human subjects in research: where are we, how did we get here, and now
      what?
PG  - 543-58
LID - 10.1111/j.1748-720X.2011.00621.x [doi]
AB  - Both international and federal regulations exist to ensure that scientists
      perform research on human subjects in an environment free of coercion and in
      which the benefits of the research are commensurate with the risks involved.
      Ensuring that these conditions hold is difficult, and perhaps even more so when
      protocols include the issue of monetary compensation of research subjects. The
      morality of paying human research subjects has been hotly debated for over 40
      years, and the grounds for this debate have ranged from discussion of legal
      rights, economic rights, philosophical principles of vulnerability and altruism
      to bioethical concepts of consent, best-interest determination, and justice
      theory. However, the thought surrounding these issues has evolved over time, and 
      the way we think about the role of the human research subject today is markedly
      different than the way we thought in the past. Society first thought of the
      research subject as an altruist, necessarily giving of his time to benefit
      society as a whole. As time progressed, many suggested that the subject should
      not need to sacrifice himself for research: if something goes wrong, someone
      should compensate the subject for injuries. The concept of redress evolved into a
      system in which subjects were offered money as an inducement to participate in
      research, sometimes merely to offset the monetary costs of participation, but
      sometimes even to mitigate the risks of the study. This article examines ethical 
      and legal conversations regarding compensation from the 1960s through today,
      examining theories of the ethics of compensation both comparatively and
      critically. In conclusion, we put forward an ethical framework for treating paid 
      research subjects, with an attempt to use this framework as a means of resolving 
      some of the more difficult problems with paying human subjects in research.
CI  - (c) 2011 American Society of Law, Medicine & Ethics, Inc.
FAU - VanderWalde, Ari
AU  - VanderWalde A
AD  - City of Hope Comprehensive Cancer Center, Duarte, California, USA.
FAU - Kurzban, Seth
AU  - Kurzban S
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Coercion
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Informed Consent
MH  - Liability, Legal
MH  - Patient Selection/*ethics
MH  - *Remuneration
MH  - Research Subjects/*economics
MH  - Risk Assessment
MH  - United States
MH  - Vulnerable Populations
EDAT- 2011/08/30 06:00
MHDA- 2012/01/20 06:00
CRDT- 2011/08/30 06:00
PHST- 2011/08/30 06:00 [entrez]
PHST- 2011/08/30 06:00 [pubmed]
PHST- 2012/01/20 06:00 [medline]
AID - 10.1111/j.1748-720X.2011.00621.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2011 Fall;39(3):543-58. doi: 10.1111/j.1748-720X.2011.00621.x.


PMID- 21871044
OWN - NLM
STAT- MEDLINE
DCOM- 20120119
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 39
IP  - 3
DP  - 2011 Fall
TI  - Justice, fairness, and membership in a class: conceptual confusions and moral
      puzzles in the regulation of human subjects research.
PG  - 488-501
LID - 10.1111/j.1748-720X.2011.00616.x [doi]
AB  - This essay examines conceptual difficulties with one of the ways in which justice
      has been understood and applied the ethical and regulatory review of human
      research. Justice requires the fair distribution of the benefits and burdens of
      research. Class membership is seen as justifying inclusion in higher hazard-no
      benefit research from which members of potentially vulnerable classes, such as
      children, typically would be excluded. I argue that class membership does not do 
      the justificatory work it is thought to do and that the use of class membership
      to justify inclusion in higher hazard-no benefit research leads to unjustified
      discrimination of sick children and offers special protections to healthy
      children.
CI  - (c) 2011 American Society of Law, Medicine & Ethics, Inc.
FAU - Iltis, Ana S
AU  - Iltis AS
AD  - Center for Bioethics, Health and Society at Wake Forest University, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Adult
MH  - Child
MH  - Child Welfare
MH  - Human Experimentation/*ethics/*legislation & jurisprudence
MH  - Humans
MH  - Nontherapeutic Human Experimentation/ethics
MH  - Research Subjects/*classification
MH  - Risk Assessment
MH  - *Social Justice
MH  - United States
MH  - *Vulnerable Populations
EDAT- 2011/08/30 06:00
MHDA- 2012/01/20 06:00
CRDT- 2011/08/30 06:00
PHST- 2011/08/30 06:00 [entrez]
PHST- 2011/08/30 06:00 [pubmed]
PHST- 2012/01/20 06:00 [medline]
AID - 10.1111/j.1748-720X.2011.00616.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2011 Fall;39(3):488-501. doi: 10.1111/j.1748-720X.2011.00616.x.


PMID- 21871042
OWN - NLM
STAT- MEDLINE
DCOM- 20120119
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 39
IP  - 3
DP  - 2011 Fall
TI  - The law, policy, and ethics of employers' use of financial incentives to improve 
      health.
PG  - 450-68
LID - 10.1111/j.1748-720X.2011.00614.x [doi]
AB  - The Patient Protection and Affordable Care Act (ACA) turns to a nontraditional
      mechanism to improve public health: employer-provided financial incentives for
      healthy behaviors. Critics raise questions about incentive programs'
      effectiveness, employer involvement, and potential discrimination. We support
      incentive program development despite these concerns. The ACA sets the stage for 
      a broad-based research and implementation agenda through which we can learn to
      structure incentive programs to not only promote public health but also address
      prevalent concerns.
CI  - (c) 2011 American Society of Law, Medicine & Ethics, Inc.
FAU - Madison, Kristin M
AU  - Madison KM
AD  - Leonard Davis Institute of Health Economics, University of Pennsylvania, PA, USA.
FAU - Volpp, Kevin G
AU  - Volpp KG
FAU - Halpern, Scott D
AU  - Halpern SD
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Employee Incentive Plans/*ethics/*legislation & jurisprudence
MH  - *Health Behavior
MH  - Health Care Costs
MH  - Health Plan Implementation
MH  - Health Promotion/ethics/legislation & jurisprudence/*methods
MH  - Humans
MH  - Patient Protection and Affordable Care Act
MH  - *Remuneration
MH  - United States
EDAT- 2011/08/30 06:00
MHDA- 2012/01/20 06:00
CRDT- 2011/08/30 06:00
PHST- 2011/08/30 06:00 [entrez]
PHST- 2011/08/30 06:00 [pubmed]
PHST- 2012/01/20 06:00 [medline]
AID - 10.1111/j.1748-720X.2011.00614.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2011 Fall;39(3):450-68. doi: 10.1111/j.1748-720X.2011.00614.x.


PMID- 21870591
OWN - NLM
STAT- MEDLINE
DCOM- 20111102
LR  - 20191112
IS  - 0929-0273 (Print)
IS  - 0929-0273 (Linking)
VI  - 18
IP  - 3
DP  - 2011 May
TI  - Saviour-sibling and the psychological, ethical and judicial issues that it
      creates: should English and French legislators close the Pandora's Box?
PG  - 293-303
AB  - Since the advent of test-tube babies, advances in the biomedical field have risen
      steadily. In parallel, the scientific body has never since ceased to debate the
      ethical issues that they arise. This is particularly the case regarding
      saviour-sibling. Saviour-sibling refers to a child who is conceived to cure an
      older brother or sister suffering from a serious family genetic disease.
      Therefore, it is meant to give birth to a child who will provide stem-cells taken
      from the umbilical cord or bone marrow afterwards, to treat an elder sick
      sibling. In England, this practice has been explicitly allowed by the new Human
      Fertilisation and Embryology Act 2008 under some strict conditions. In France,
      this practice, authorized by the Bioethics Law of August 2004 and confirmed by
      its decree of implementation published in the Official Journal on 23 December
      2006, is also strictly regulated. This technique opens up new perspectives and
      enormous hope. Its legalisation is certainly justified by the suffering of the
      parents and to avoid that they travel to other States where it is permitted.
      However, it raises serious psychological ethical and judicial issues. Following
      an analysis of the English and French laws on saviour siblings, its controversial
      side will be highlighted, before concluding whether or not this new Pandora's box
      which is saviour-sibling, should be closed and other alternative methods
      encouraged.
FAU - Madanamoothoo, Allane
AU  - Madanamoothoo A
AD  - IRDEIC, France.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Eur J Health Law
JT  - European journal of health law
JID - 9431861
SB  - IM
MH  - Bone Marrow Transplantation/*ethics
MH  - Cord Blood Stem Cell Transplantation/*ethics
MH  - Directed Tissue Donation/*ethics
MH  - France
MH  - Histocompatibility Testing
MH  - Humans
MH  - Preimplantation Diagnosis/ethics
MH  - *Siblings/psychology
MH  - United Kingdom
EDAT- 2011/08/30 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/08/30 06:00
PHST- 2011/08/30 06:00 [entrez]
PHST- 2011/08/30 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
AID - 10.1163/157180911x574119 [doi]
PST - ppublish
SO  - Eur J Health Law. 2011 May;18(3):293-303. doi: 10.1163/157180911x574119.


PMID- 21870412
OWN - NLM
STAT- MEDLINE
DCOM- 20110914
LR  - 20110829
IS  - 1003-0034 (Print)
IS  - 1003-0034 (Linking)
VI  - 24
IP  - 7
DP  - 2011 Jul
TI  - [Current situation and progression of induced pluripotent stem cells in treating 
      spinal cord injury].
PG  - 616-20
AB  - Spinal cord injury is a difficult medical problem and current therapeutic methods
      could not obtain satisfactory results. Recent 20 years, stem cell technology
      developed rapidly, embryonic stem cells and adult stem cells were used for
      treating neurological disease and nerve injury of animal models and the clinical 
      results were confirmed. It provided a new prospect for the treatment of nerve
      injury at the cellular level. However,due to technical and ethical problems, it
      is difficult to obtain the appropriate cells that can be applied to the human
      being. Recently, induced pluripotent stem cells were developed as a new method
      for the treatment of spinal cord injuries by the autologous transplantation.
      Starting from this work, the purpose of this review is to assess the
      differentiate ability of induced pluripotent stem cells into neurocyte and review
      the latest developments in this area.
FAU - Liu, Wei
AU  - Liu W
AD  - Department of Spinal Surgery, the First Clinical Hospital of Jilin University,
      Changchun 130021, Jilin, China.
FAU - Zhang, Shao-kun
AU  - Zhang SK
FAU - Yan, Ming
AU  - Yan M
FAU - Liu, Li-di
AU  - Liu LD
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - China
TA  - Zhongguo Gu Shang
JT  - Zhongguo gu shang = China journal of orthopaedics and traumatology
JID - 9815790
SB  - IM
MH  - Humans
MH  - Neoplasms/etiology
MH  - Pluripotent Stem Cells/cytology/*transplantation
MH  - Spinal Cord Injuries/pathology/*therapy
MH  - Stem Cell Transplantation/adverse effects/*methods
EDAT- 2011/08/30 06:00
MHDA- 2011/09/15 06:00
CRDT- 2011/08/30 06:00
PHST- 2011/08/30 06:00 [entrez]
PHST- 2011/08/30 06:00 [pubmed]
PHST- 2011/09/15 06:00 [medline]
PST - ppublish
SO  - Zhongguo Gu Shang. 2011 Jul;24(7):616-20.


PMID- 21869665
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20110929
IS  - 1938-808X (Electronic)
IS  - 1040-2446 (Linking)
VI  - 86
IP  - 10
DP  - 2011 Oct
TI  - Medical students' experiences of professional lapses and patient rights abuses in
      a South African health sciences faculty.
PG  - 1282-7
LID - 10.1097/ACM.0b013e31822be4b8 [doi]
AB  - PURPOSE: To elicit South African medical students' experiences of witnessing
      patient rights abuses and professional lapses during their clinical training in
      order to inform an appropriate and effective response. METHOD: During June and
      July 2009 at the University of Cape Town Faculty of Health Sciences, the authors 
      surveyed 223 fourth-, fifth-, and sixth-year medical students in selected
      clinical rotations concerning abuses they had observed. Volunteers were later
      interviewed individually. The authors coded interview transcripts for key themes 
      using a constant-comparative grounded theory approach. RESULTS: Of 223 students
      surveyed, 183 (82%) responded, 130 (71%) of whom reported witnessing patient
      rights abuses and professional lapses, including physical abuse (38%), verbal
      abuse (37%), disrespect for patients' dignity (25%), and inadequately informing
      patients about their treatment (25%). Students attributed abuse to stressed
      health workers, overburdened facilities, and disempowered patients. Most students
      who witnessed abuse (59%) did not actively respond, and 64% of survey respondents
      felt unprepared or uncertain about challenging abuses in the future. Interviews
      with 28 students yielded detailed accounts of the abuses witnessed and of
      students' emotional reactions, coping strategies, and responses. Most students
      did not report abuses; they feared reprisal or doubted it would make a
      difference. CONCLUSIONS: This study demonstrates the disjunction between what
      these students were taught about human rights and ethics and what they witnessed 
      in clinical settings. The high prevalence of patient rights abuses experienced by
      these students highlights the need to align medical ethics and human rights with 
      medico-legal protocols in theory and clinical practice.
FAU - Vivian, Lauraine M H
AU  - Vivian LM
AD  - Primary Health Care Directorate, Faculty of Health Sciences, University of Cape
      Town, Cape Town, South Africa. Lauraine.Vivian@uct.ac.za
FAU - Naidu, Claudia S
AU  - Naidu CS
FAU - Keikelame, Mpoe J
AU  - Keikelame MJ
FAU - Irlam, James
AU  - Irlam J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Acad Med
JT  - Academic medicine : journal of the Association of American Medical Colleges
JID - 8904605
SB  - IM
MH  - Adolescent
MH  - Education, Medical, Undergraduate/*organization & administration
MH  - Ethics, Medical/*education
MH  - *Faculty, Medical
MH  - Female
MH  - *Human Rights
MH  - Humans
MH  - Male
MH  - Physician-Patient Relations/*ethics
MH  - Professional Misconduct/*ethics
MH  - Program Evaluation
MH  - Retrospective Studies
MH  - South Africa
MH  - Students, Medical/*psychology
MH  - Young Adult
EDAT- 2011/08/27 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/08/27 06:00
PHST- 2011/08/27 06:00 [entrez]
PHST- 2011/08/27 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1097/ACM.0b013e31822be4b8 [doi]
PST - ppublish
SO  - Acad Med. 2011 Oct;86(10):1282-7. doi: 10.1097/ACM.0b013e31822be4b8.


PMID- 21867956
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20211020
IS  - 1474-4457 (Electronic)
IS  - 1473-3099 (Linking)
VI  - 11
IP  - 9
DP  - 2011 Sep
TI  - Antiscience and ethical concerns associated with advocacy of Lyme disease.
PG  - 713-9
LID - 10.1016/S1473-3099(11)70034-2 [doi]
AB  - Advocacy for Lyme disease has become an increasingly important part of an
      antiscience movement that denies both the viral cause of AIDS and the benefits of
      vaccines and that supports unproven (sometimes dangerous) alternative medical
      treatments. Some activists portray Lyme disease, a geographically limited
      tick-borne infection, as a disease that is insidious, ubiquitous, difficult to
      diagnose, and almost incurable; they also propose that the disease causes mainly 
      non-specific symptoms that can be treated only with long-term antibiotics and
      other unorthodox and unvalidated treatments. Similar to other antiscience groups,
      these advocates have created a pseudoscientific and alternative selection of
      practitioners, research, and publications and have coordinated public protests,
      accused opponents of both corruption and conspiracy, and spurred legislative
      efforts to subvert evidence-based medicine and peer-reviewed science. The
      relations and actions of some activists, medical practitioners, and commercial
      bodies involved in Lyme disease advocacy pose a threat to public health.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Auwaerter, Paul G
AU  - Auwaerter PG
AD  - Division of Infectious Diseases, Department of Medicine, The Johns Hopkins
      Medical Institutions, Baltimore, MD 21205, USA. pgauwaerter@gmail.com
FAU - Bakken, Johan S
AU  - Bakken JS
FAU - Dattwyler, Raymond J
AU  - Dattwyler RJ
FAU - Dumler, J Stephen
AU  - Dumler JS
FAU - Halperin, John J
AU  - Halperin JJ
FAU - McSweegan, Edward
AU  - McSweegan E
FAU - Nadelman, Robert B
AU  - Nadelman RB
FAU - O'Connell, Susan
AU  - O'Connell S
FAU - Shapiro, Eugene D
AU  - Shapiro ED
FAU - Sood, Sunil K
AU  - Sood SK
FAU - Steere, Allen C
AU  - Steere AC
FAU - Weinstein, Arthur
AU  - Weinstein A
FAU - Wormser, Gary P
AU  - Wormser GP
LA  - eng
GR  - K24 RR022477/RR/NCRR NIH HHS/United States
GR  - KL2 RR024138/RR/NCRR NIH HHS/United States
GR  - UL1 RR024139/RR/NCRR NIH HHS/United States
GR  - UL1 TR000142/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Lancet Infect Dis
JT  - The Lancet. Infectious diseases
JID - 101130150
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
CIN - Lancet Infect Dis. 2012 May;12(5):361; author reply 362-3. PMID: 22541623
CIN - Lancet Infect Dis. 2012 May;12(5):361-2; author reply 362-3. PMID: 22541624
CIN - Lancet Infect Dis. 2012 May;12(5):362; author reply 362-3. PMID: 22541626
MH  - Anti-Bacterial Agents/*administration & dosage/therapeutic use
MH  - *Borrelia burgdorferi
MH  - Chronic Disease
MH  - Consumer Advocacy/*ethics
MH  - Humans
MH  - Lyme Disease/*drug therapy/microbiology
MH  - Physicians/*ethics
MH  - Practice Guidelines as Topic
MH  - Professional Misconduct/*ethics
MH  - Propaganda
PMC - PMC4489928
MID - NIHMS703480
EDAT- 2011/08/27 06:00
MHDA- 2011/10/25 06:00
CRDT- 2011/08/27 06:00
PHST- 2011/08/27 06:00 [entrez]
PHST- 2011/08/27 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
AID - S1473-3099(11)70034-2 [pii]
AID - 10.1016/S1473-3099(11)70034-2 [doi]
PST - ppublish
SO  - Lancet Infect Dis. 2011 Sep;11(9):713-9. doi: 10.1016/S1473-3099(11)70034-2.


PMID- 21867864
OWN - NLM
STAT- MEDLINE
DCOM- 20111219
LR  - 20191210
IS  - 1532-656X (Electronic)
IS  - 0891-5245 (Linking)
VI  - 25
IP  - 5
DP  - 2011 Sep-Oct
TI  - Remembering the "Seven Rs": more ethical caveats for the PNP hospitalist.
PG  - 338-41
LID - 10.1016/j.pedhc.2011.05.003 [doi]
FAU - Fernandes, Ashley K
AU  - Fernandes AK
AD  - Department of Community Health and Pediatrics, Boonshoft School of
      Medicine,Wright State University, Dayton, OH 45435, USA.
      ashley.fernandes@wright.edu
FAU - Onady, Gary M
AU  - Onady GM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pediatr Health Care
JT  - Journal of pediatric health care : official publication of National Association
      of Pediatric Nurse Associates & Practitioners
JID - 8709735
MH  - Conflict, Psychological
MH  - *Ethics, Professional
MH  - *Hospitalists
MH  - Humans
MH  - Models, Theoretical
MH  - *Nurse Practitioners
MH  - Pediatrics
MH  - Professional-Family Relations
EDAT- 2011/08/27 06:00
MHDA- 2011/12/20 06:00
CRDT- 2011/08/27 06:00
PHST- 2011/05/20 00:00 [received]
PHST- 2011/05/25 00:00 [accepted]
PHST- 2011/08/27 06:00 [entrez]
PHST- 2011/08/27 06:00 [pubmed]
PHST- 2011/12/20 06:00 [medline]
AID - S0891-5245(11)00185-4 [pii]
AID - 10.1016/j.pedhc.2011.05.003 [doi]
PST - ppublish
SO  - J Pediatr Health Care. 2011 Sep-Oct;25(5):338-41. doi:
      10.1016/j.pedhc.2011.05.003.


PMID- 21867453
OWN - NLM
STAT- MEDLINE
DCOM- 20120116
LR  - 20200505
IS  - 1619-3997 (Electronic)
IS  - 0300-5577 (Linking)
VI  - 39
IP  - 5
DP  - 2011 Sep
TI  - Decision-making at the border of viability by means of values clarification: a
      case study to achieve distinct communication by ordinary language approach.
PG  - 595-603
LID - 10.1515/jpm.2011.066 [doi]
AB  - OBJECTIVES: We set out to investigate the major obstacles in achieving a
      sensitive and supportive communication between parents and clinicians in ethical 
      dilemma situations. We focused on discussions in emergency situations by means of
      values clarification. METHODS: The study population (n=141) covers four samples
      of clinical staff (n(1)=72) from different specialties and parents of preterm and
      term infants (n(2)=69). Because of the vulnerability of parents and the virulence
      of the topic, the descriptive qualitative case study comprises standardized
      questionnaires and half-standardized interviews. Data were analyzed graphically
      and statistically, comparing parents and professionals for the justification of
      acting using values clarification in this context. RESULTS: Our study indicated
      that the use of a critically reconsidered and less personalized language has to
      be a major goal in the care of preterm infants at the edge of viability.
      Furthermore we found that acting ethically means making decisions individually by
      using open-context terms sensitively in consideration of diverging action-guiding
      principles. CONCLUSIONS: Decisions in medicine concern different people - experts
      as well as patients and their representatives. The present study is an attempt to
      establish more awareness for improved communication, which is a part of
      professionalism, as well as coping strategies for all involved.
FAU - Paulmichl, Katharina
AU  - Paulmichl K
AD  - Paracelsus Medical School, Salzburg University, Salzburg, Austria.
      katharina.paulmichl@pmu.ac.at
FAU - Hattinger-Jurgenssen, Erna
AU  - Hattinger-Jurgenssen E
FAU - Maier, Barbara
AU  - Maier B
LA  - eng
PT  - Journal Article
DEP - 20110826
PL  - Germany
TA  - J Perinat Med
JT  - Journal of perinatal medicine
JID - 0361031
SB  - IM
MH  - Communication
MH  - Decision Making
MH  - Ethics, Medical
MH  - Female
MH  - *Fetal Viability
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Language
MH  - Medical Futility
MH  - Neonatology/ethics
MH  - Parents
MH  - Pregnancy
MH  - Prognosis
MH  - Social Values
EDAT- 2011/08/27 06:00
MHDA- 2012/01/17 06:00
CRDT- 2011/08/27 06:00
PHST- 2011/08/27 06:00 [entrez]
PHST- 2011/08/27 06:00 [pubmed]
PHST- 2012/01/17 06:00 [medline]
AID - 10.1515/jpm.2011.066 [doi]
PST - ppublish
SO  - J Perinat Med. 2011 Sep;39(5):595-603. doi: 10.1515/jpm.2011.066. Epub 2011 Aug
      26.


PMID- 21867384
OWN - NLM
STAT- MEDLINE
DCOM- 20111109
LR  - 20110826
IS  - 1364-6915 (Electronic)
IS  - 1360-7863 (Linking)
VI  - 15
IP  - 7
DP  - 2011 Sep
TI  - Do people with dementia find lies and deception in dementia care acceptable?
PG  - 822-9
LID - 10.1080/13607863.2011.569489 [doi]
AB  - OBJECTIVES: Research suggests that the use of lies and deception are prevalent in
      dementia care settings. This issue has been explored from the view point of
      carers and professionals, and the acceptability and ethicality of deception in
      dementia care remains an area of heated debate. This article explored the issue
      of lies and deception in dementia care from the unique perspective of the people 
      being lied to: People with Dementia. METHOD: This study used a qualitative
      methodology, specifically, Grounded Theory (GT). The study used a two-phased
      design. Phase one involved a series of one-to-one interviews with People with
      Dementia. During phase two, the participants were re-interviewed in order to
      develop the emerging theory. RESULTS: Lies were considered to be acceptable if
      told in People with Dementia's best interest. This best interest decision was
      complex, and influenced by factors such as the person with dementia's awareness
      of the lie, and the carer's motivation for lying. A model depicting these factors
      is discussed. CONCLUSION: This study enables the perspective of People with
      Dementia to be considered, therefore providing a more complete understanding of
      the use of deceptive practices in dementia care settings. This study suggests
      that the use of lies and deception in dementia care warrants further
      investigation.
FAU - Day, Anna M
AU  - Day AM
AD  - The Community Learning Disabilities Team, Northumbria Healthcare NHS Trust,
      Longbenton, North Tyneside, Newcastle upon Tyne, UK. a.waterworth@nhs.net
FAU - James, Ian A
AU  - James IA
FAU - Meyer, Thomas D
AU  - Meyer TD
FAU - Lee, David R
AU  - Lee DR
LA  - eng
PT  - Journal Article
DEP - 20110621
PL  - England
TA  - Aging Ment Health
JT  - Aging & mental health
JID - 9705773
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Awareness
MH  - Caregivers/*psychology
MH  - Decision Making
MH  - Dementia/nursing/*psychology/*therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Motivation
MH  - *Truth Disclosure
EDAT- 2011/08/27 06:00
MHDA- 2011/11/10 06:00
CRDT- 2011/08/27 06:00
PHST- 2011/08/27 06:00 [entrez]
PHST- 2011/08/27 06:00 [pubmed]
PHST- 2011/11/10 06:00 [medline]
AID - 10.1080/13607863.2011.569489 [doi]
PST - ppublish
SO  - Aging Ment Health. 2011 Sep;15(7):822-9. doi: 10.1080/13607863.2011.569489. Epub 
      2011 Jun 21.


PMID- 21866836
OWN - NLM
STAT- MEDLINE
DCOM- 20110923
LR  - 20171116
IS  - 0869-8031 (Print)
IS  - 0869-8031 (Linking)
VI  - 51
IP  - 3
DP  - 2011 May-Jun
TI  - [Mobile communication and health of population: estimation of danger, social and 
      ethical problems].
PG  - 357-68
AB  - Population lives under new electromagnetic conditions: constant round-the-clock
      compulsory chronic exposure of all groups of population to modulated wide
      spectrum of EMF RF during the work of base stations of mobile communication;
      daily and lifelong (from childhood) exposure of the brain to EMF RF of the mobile
      phone. Effects of exposure to EMF RF of low levels are presented. Results of
      research into chronic EMF RF exposure are absent. International recommendations
      and domestic guidelines do not take into account the changing conditions of EMF
      RF influence on the population: the brain has become a critical body, and
      children have been included in the risk group. Population actively continues to
      use mobile communication. In this situation estimation of the risks from mobile
      communication has become a social and ethical problem.
FAU - Grigor'ev, Iu G
AU  - Grigor'ev IuG
FAU - Grigor'ev, O A
AU  - Grigor'ev OA
LA  - rus
PT  - Journal Article
PL  - Russia (Federation)
TA  - Radiats Biol Radioecol
JT  - Radiatsionnaia biologiia, radioecologiia
JID - 9317212
SB  - IM
MH  - Animals
MH  - *Bioethical Issues
MH  - Brain/radiation effects
MH  - *Cell Phone/standards
MH  - Electromagnetic Fields/*adverse effects
MH  - Environmental Exposure/*adverse effects
MH  - Environmental Health/*standards
MH  - Health Status
MH  - Humans
MH  - Risk Assessment
MH  - Socioeconomic Factors
MH  - Stress, Psychological
EDAT- 2011/08/27 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/08/27 06:00
PHST- 2011/08/27 06:00 [entrez]
PHST- 2011/08/27 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
PST - ppublish
SO  - Radiats Biol Radioecol. 2011 May-Jun;51(3):357-68.


PMID- 21866365
OWN - NLM
STAT- MEDLINE
DCOM- 20120705
LR  - 20181201
IS  - 1573-6768 (Electronic)
IS  - 1389-5729 (Linking)
VI  - 13
IP  - 1
DP  - 2012 Feb
TI  - Biogerontology: from here to where? The Lord Cohen Medal Lecture-2011.
PG  - 83-91
LID - 10.1007/s10522-011-9354-3 [doi]
AB  - Ageing is a progressive shrinkage of the homeodynamic space and, at the molecular
      level, it is associated with the stochastic occurrence and progressive
      accumulation of molecular damage. Imperfection of the maintenance and repair
      systems results in the failure of homeodynamics characterized by increased
      molecular heterogeneity, altered cellular functioning, reduced stress tolerance
      and reduced remodeling and adaptation, which lead to increased probability of
      diseases and eventual death. Although, several types of molecular damages have
      been shown to accumulate and increase molecular heterogeneity during ageing, its 
      relevance and significance with respect to the physiology, survival and longevity
      remains to be determined. Such studies are essential for establishing biomarkers 
      of health, frailty, remodeling and adaptation, and for developing effective
      methods for the prevention and reversion of age-related changes. A promising
      strategy for ageing intervention and modulation is that of strengthening the
      homeodynamics through repeated mild stress-induced hormesis by physical,
      biological and nutritional hormetins. Because a number of ethical, social, and
      personal implications emerge by the development and use of anti-ageing and
      life-extending technologies, biogerontologists should incorporate these elements 
      while developing their research agenda in biogerontology.
FAU - Rattan, Suresh I S
AU  - Rattan SI
AD  - Laboratory of Cellular Ageing, Department of Molecular Biology and Genetics,
      Aarhus University, Aarhus C, Denmark. rattan@mb.au.dk
LA  - eng
PT  - Lecture
DEP - 20110825
PL  - Netherlands
TA  - Biogerontology
JT  - Biogerontology
JID - 100930043
SB  - IM
MH  - *Geriatrics
MH  - Humans
EDAT- 2011/08/26 06:00
MHDA- 2012/07/06 06:00
CRDT- 2011/08/26 06:00
PHST- 2011/07/08 00:00 [received]
PHST- 2011/08/18 00:00 [accepted]
PHST- 2011/08/26 06:00 [entrez]
PHST- 2011/08/26 06:00 [pubmed]
PHST- 2012/07/06 06:00 [medline]
AID - 10.1007/s10522-011-9354-3 [doi]
PST - ppublish
SO  - Biogerontology. 2012 Feb;13(1):83-91. doi: 10.1007/s10522-011-9354-3. Epub 2011
      Aug 25.


PMID- 21866180
OWN - NLM
STAT- MEDLINE
DCOM- 20120216
LR  - 20111019
IS  - 1745-655X (Electronic)
IS  - 0197-5897 (Linking)
VI  - 32
IP  - 4
DP  - 2011 Nov
TI  - Care drain: the political making of health worker migration.
PG  - 489-98
LID - 10.1057/jphp.2011.43 [doi]
AB  - Migration of formal and informal health-care workers is a global phenomenon -
      and, as this article demonstrates, one that is produced by government policies
      and practices. Nurses and lesser-trained caregivers migrate from many
      lower-income countries to richer ones (including from the Philippines to the
      United States, from South Africa to England, from Central Asia to Turkey). Using 
      the Austrian experience to illustrate how policies and lack of enforcement of
      labor laws lead to migration and mistreatment of health-care professionals and
      informal caregivers, this article recommends how to alleviate health-care staff
      shortages in Africa and elsewhere through policymaking in Europe and North
      America. Recognition of the political dimensions of health-care migration is the 
      first step toward addressing ethical questions and damaging shortages of
      caregivers.
FAU - Kaelin, Lukas
AU  - Kaelin L
AD  - Institute for Ethics and Law in Medicine, University of Vienna, Schenkenstr.
      8-10, Vienna 1010, Austria. lukas.kaelin@univie.ac.at
LA  - eng
PT  - Journal Article
DEP - 20110825
PL  - England
TA  - J Public Health Policy
JT  - Journal of public health policy
JID - 8006508
SB  - IM
MH  - Africa
MH  - Caregivers/economics/statistics & numerical data
MH  - *Emigration and Immigration/legislation & jurisprudence/trends
MH  - Europe
MH  - Health Personnel/economics/*statistics & numerical data
MH  - *Health Policy/economics
MH  - Humans
MH  - North America
MH  - Personnel Selection
MH  - Philippines
MH  - Population Dynamics
EDAT- 2011/08/26 06:00
MHDA- 2012/02/18 06:00
CRDT- 2011/08/26 06:00
PHST- 2011/08/26 06:00 [entrez]
PHST- 2011/08/26 06:00 [pubmed]
PHST- 2012/02/18 06:00 [medline]
AID - jphp201143 [pii]
AID - 10.1057/jphp.2011.43 [doi]
PST - ppublish
SO  - J Public Health Policy. 2011 Nov;32(4):489-98. doi: 10.1057/jphp.2011.43. Epub
      2011 Aug 25.


PMID- 21865995
OWN - NLM
STAT- MEDLINE
DCOM- 20111013
LR  - 20210106
IS  - 1529-4242 (Electronic)
IS  - 0032-1052 (Linking)
VI  - 128
IP  - 3
DP  - 2011 Sep
TI  - Volunteers in plastic surgery guidelines for providing surgical care for children
      in the less developed world: part II. Ethical considerations.
PG  - 216e-222e
LID - 10.1097/PRS.0b013e31822213b4 [doi]
AB  - BACKGROUND: Many international volunteer groups provide free reconstructive
      plastic surgery for the poor and underserved in developing countries. An
      essential issue in providing this care is that it meets consistent guidelines for
      both quality and safety-a topic that has been addressed previously. An equally
      important consideration is how to provide that care in an ethical manner. No
      literature presently addresses the various issues involved in making those
      decisions. METHODS: With these ethical considerations in mind, the Volunteers in 
      Plastic Surgery Committee of the American Society of Plastic Surgeons/Plastic
      Surgery Foundation undertook a project to create a comprehensive set of
      guidelines for volunteer groups planning to provide this type of reconstructive
      plastic surgery in developing countries. The committee worked in conjunction with
      the Society for Pediatric Anesthesia on this project. RESULTS: The Board of the
      American Society of Plastic Surgeons/Plastic Surgery Foundation has approved the 
      ethical guidelines created for the delivery of care in developing countries. The 
      guidelines address the variety of ethical decisions that may be faced by a team
      working in an underdeveloped country. These guidelines make it possible for a
      humanitarian effort to anticipate the types of ethical decisions that are often
      encountered and be prepared to deal with them appropriately. CONCLUSIONS: Any
      group seeking to undertake an international mission trip in plastic surgery
      should be able to go to one source to find a detailed discussion of the perceived
      needs in providing ethical humanitarian care. This document was created to
      satisfy that need and is a companion to our original guidelines addressing safety
      and quality.
FAU - Schneider, William J
AU  - Schneider WJ
AD  - Knoxville, Tenn.; Minneapolis and Rochester, Minn.; Cleveland, Ohio; and San
      Francisco, Calif. From Fort Sanders Regional Medical Center; Abbott Northeastern 
      Hospital; the Department of Plastic Surgery, Case Western Reserve University; the
      Departments of Pediatrics and Anesthesia, University of California, San
      Francisco; and the Department of Anesthesiology, Mayo Clinic College of Medicine.
FAU - Migliori, Mark R
AU  - Migliori MR
FAU - Gosain, Arun K
AU  - Gosain AK
FAU - Gregory, George
AU  - Gregory G
FAU - Flick, Randall
AU  - Flick R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Plast Reconstr Surg
JT  - Plastic and reconstructive surgery
JID - 1306050
SB  - IM
MH  - *Altruism
MH  - *Developing Countries
MH  - Ethics, Medical
MH  - Guideline Adherence/*ethics
MH  - Health Services Needs and Demand/ethics
MH  - Humans
MH  - Medical Missions/ethics
MH  - Quality Assurance, Health Care/ethics
MH  - Reconstructive Surgical Procedures/*ethics
MH  - Safety Management/ethics
MH  - *Volunteers
EDAT- 2011/08/26 06:00
MHDA- 2011/10/14 06:00
CRDT- 2011/08/26 06:00
PHST- 2011/08/26 06:00 [entrez]
PHST- 2011/08/26 06:00 [pubmed]
PHST- 2011/10/14 06:00 [medline]
AID - 10.1097/PRS.0b013e31822213b4 [doi]
AID - 00006534-201109000-00033 [pii]
PST - ppublish
SO  - Plast Reconstr Surg. 2011 Sep;128(3):216e-222e. doi:
      10.1097/PRS.0b013e31822213b4.


PMID- 21864078
OWN - NLM
STAT- MEDLINE
DCOM- 20120203
LR  - 20211008
IS  - 1744-8360 (Electronic)
IS  - 1473-7175 (Linking)
VI  - 11
IP  - 9
DP  - 2011 Sep
TI  - Cell replacement therapy for Parkinson's disease: how close are we to the clinic?
PG  - 1325-39
LID - 10.1586/ern.11.74 [doi]
AB  - Cell replacement therapy (CRT) offers great promise as the future of regenerative
      medicine in Parkinson s disease (PD). Three decades of experiments have
      accumulated a wealth of knowledge regarding the replacement of dying neurons by
      new and healthy dopaminergic neurons transplanted into the brains of animal
      models and affected patients. The first clinical trials provided the proof of
      principle for CRT in PD. In these experiments, intrastriatal transplantation of
      human embryonic mesencephalic tissue reinnervated the striatum, restored dopamine
      levels and showed motor improvements. Sequential controlled studies highlighted
      several problems that should be addressed prior to the wide application of CRT
      for PD patients. Moreover, owing to ethical and practical problems, embryonic
      stem cells require replacement by better-suited stem cells. Several obstacles
      remain to be surpassed, including identifying the best source of stem cells for
      A9 dopaminergic neuron generation, eliminating the risk of tumor formation and
      the development of graft-induced dyskinesias, and standardizing dopaminergic cell
      production in order to enable clinical application. In this article, we present
      an update on CRT for PD, reviewing the research milestones, various stem cells
      used and tailored differentiation methods, and analyze the information gained
      from the clinical trials.
FAU - Ganz, Javier
AU  - Ganz J
AD  - Laboratory of Neuroscience, Felsenstein Medical Research Center, Rabin Medical
      Center, Tel Aviv University, Israel.
FAU - Lev, Nirit
AU  - Lev N
FAU - Melamed, Eldad
AU  - Melamed E
FAU - Offen, Daniel
AU  - Offen D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Expert Rev Neurother
JT  - Expert review of neurotherapeutics
JID - 101129944
SB  - IM
MH  - Cell Differentiation/physiology
MH  - Cell Transplantation/adverse effects/*physiology
MH  - Dopaminergic Neurons/physiology
MH  - Humans
MH  - Parkinson Disease/pathology/*therapy
MH  - Stem Cells/physiology
EDAT- 2011/08/26 06:00
MHDA- 2012/02/04 06:00
CRDT- 2011/08/26 06:00
PHST- 2011/08/26 06:00 [entrez]
PHST- 2011/08/26 06:00 [pubmed]
PHST- 2012/02/04 06:00 [medline]
AID - 10.1586/ern.11.74 [doi]
PST - ppublish
SO  - Expert Rev Neurother. 2011 Sep;11(9):1325-39. doi: 10.1586/ern.11.74.


PMID- 21863693
OWN - NLM
STAT- MEDLINE
DCOM- 20110906
LR  - 20110825
IS  - 0019-1442 (Print)
IS  - 0019-1442 (Linking)
VI  - 64
IP  - 7-8
DP  - 2011 Jul 30
TI  - [Initial clinical experience with radiofrequency-guided percutaneous vertebral
      augmentation in the treatment of vertebral compression fractures].
PG  - 257-61
AB  - PURPOSE: Percutaenous Vertebroplasty (PVP) is effective in alleviating pain and
      facilitating early mobilization following vertebral compression fractures. The
      relatively high risk of extravertebral leakage due to uncontrolled delivery of
      low viscosity bone cement is an inherent limitation of the technique. The aim of 
      this research is to investigate the ability of controlled cement delivery in
      decreasing the rate of such complications by applying radiofrequency heating to
      regulate cement viscosity. METHOD AND MATERIAL: Thirty two vetebrae were treated 
      in 28 patients as part of an Ethics Committee approved multicenter clinical trial
      using RadioFreqency assisted Percutaenous Vertebral Augmentation (RF-PVA)
      technique. This technique is injecting low viscosity polymethylmethacrylate
      (PMMA) bone cement using a pressure controlled hydraulic pump and applying
      radiofrequency heating to increase cement viscosity prior to entering the
      vertebral body. All patients were screened for any cement leakage by X-ray and CT
      scan. The intensity of pain was recorded on a Visual Analog Scale (VAS) and the
      level of physical activity on the Oswestry Disability Index (ODI) prior to, one
      day, one month and three months following procedure. RESULTS: All procedures were
      technically successful. There were no clinical complication, intraspinal or
      intraforaminal cement leakage. In nine cases (29%) a small amount of PMMA entered
      the intervertebral space through the broken end plate. Intensity of pain by VAS
      was reduced from a mean of 7.0 to 2.5 and physical inactivity dropped on the ODI 
      from 52% to 23% three months following treatment. CONCLUSION: In this small
      series controlled cement injection using RF-PVA was capable of preventing
      clinically hazardous extravertebral cement leakage while achieving outcomes
      similar to that of conventional vertebroplasty.
FAU - Marosfoi, Miklos
AU  - Marosfoi M
AD  - Orszagos Idegtudomanyi Intezet, Budapest.
FAU - Kulcsar, Zsolt
AU  - Kulcsar Z
FAU - Berentei, Zsolt
AU  - Berentei Z
FAU - Gubucz, Istvan
AU  - Gubucz I
FAU - Szikora, Istvan
AU  - Szikora I
LA  - hun
PT  - Clinical Trial
PT  - English Abstract
PT  - Journal Article
PT  - Multicenter Study
TT  - Radiofrekvencia-tamogatott percutan csigolyastabilizacioval szerzett elso
      klinikai tapasztalataink kompresszios csigolyatoresek kezeleseben.
PL  - Hungary
TA  - Ideggyogy Sz
JT  - Ideggyogyaszati szemle
JID - 17510500R
RN  - 0 (Bone Cements)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Bone Cements/*therapeutic use
MH  - Female
MH  - Fracture Healing
MH  - Fractures, Compression/complications/*surgery
MH  - Hot Temperature
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pain/etiology
MH  - Pain Measurement
MH  - Radiosurgery/*methods
MH  - Spinal Fractures/complications/*surgery
MH  - Surgery, Computer-Assisted/methods
MH  - Treatment Outcome
MH  - Vertebroplasty/*methods
MH  - Viscosity
EDAT- 2011/08/26 06:00
MHDA- 2011/09/07 06:00
CRDT- 2011/08/26 06:00
PHST- 2011/08/26 06:00 [entrez]
PHST- 2011/08/26 06:00 [pubmed]
PHST- 2011/09/07 06:00 [medline]
PST - ppublish
SO  - Ideggyogy Sz. 2011 Jul 30;64(7-8):257-61.


PMID- 21863687
OWN - NLM
STAT- MEDLINE
DCOM- 20110908
LR  - 20151119
IS  - 0125-2208 (Print)
IS  - 0125-2208 (Linking)
VI  - 94
IP  - 8
DP  - 2011 Aug
TI  - Current status of the research ethics committees in Thailand.
PG  - 1013-8
AB  - BACKGROUND: Many research ethics committees (RECs) have been established to
      review biomedical research involving human subjects in many research institutes. 
      The purpose is "To protect rights and welfare of human research participants". It
      is necessary to determine how many research ethics committees have been
      established in Thailand and whether they have a high enough standard toprotect
      the rights and welfare of human research subjects. OBJECTIVE: To determine the
      status of research ethics committees in Thailand. MATERIAL AND METHOD: One
      hundred thirty survey questionnaires were distributed by mail to medical schools 
      of universities, public hospitals under the Ministry of Public Health, private
      hospitals, and research institutes. RESULTS: Seventy-eight questionnaires were
      returned. Thirty respondents had standard Operating Procedures (SOP). Twenty-two 
      RECs had their own office while 36 had to share the office with other departments
      or units. Board meeting frequency was once a month. The average number of
      committee members was 14 and the majority was scientific members. Absence of
      nonaffiliated members was found in RECs (20.6%). Thirty RECs had never provided
      training for REC members and investigators, the other 48 provided training at
      least once a year Decision are made by consensus in 51 and majority vote in 14
      RECs. Twenty-two respondents managed conflicts of interest (COI) by asking those 
      members to leave the meeting before a decision was finalized. Thirty-nine RECs
      required continuous review after approval of the protocols. CONCLUSION: Strong
      support from the organization leader is a key factor to efficiency and high
      standards of REC operation. Developing a network of RECs will be useful for
      future development. REC members still need knowledge to better protect the
      rights, safety, and well-being of research participants.
FAU - Panichkul, Suthee
AU  - Panichkul S
AD  - Office of Research Development, Phramongkutklao College of Medicine and Hospital,
      Bangkok, Thailand. sthpanich@hotmail.com
FAU - Mahaisavariya, Punkae
AU  - Mahaisavariya P
FAU - Morakote, Nimit
AU  - Morakote N
FAU - Condo, Sumalee
AU  - Condo S
FAU - Caengow, Supak
AU  - Caengow S
FAU - Ketunpanya, Aphronpirom
AU  - Ketunpanya A
LA  - eng
PT  - Journal Article
PL  - Thailand
TA  - J Med Assoc Thai
JT  - Journal of the Medical Association of Thailand = Chotmaihet thangphaet
JID - 7507216
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Conflict of Interest
MH  - Ethics Committees, Research/*standards
MH  - Ethics, Research
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Public Health
MH  - *Research Subjects
MH  - Surveys and Questionnaires
MH  - Thailand
EDAT- 2011/08/26 06:00
MHDA- 2011/09/09 06:00
CRDT- 2011/08/26 06:00
PHST- 2011/08/26 06:00 [entrez]
PHST- 2011/08/26 06:00 [pubmed]
PHST- 2011/09/09 06:00 [medline]
PST - ppublish
SO  - J Med Assoc Thai. 2011 Aug;94(8):1013-8.


PMID- 21863146
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 2155-9627 (Print)
VI  - 2
IP  - 108
DP  - 2011 Mar 31
TI  - Pregnancy and Protection: The Ethics of Limiting a Pregnant Woman's Participation
      in Clinical Trials.
LID - 1000108 [pii]
AB  - The call for the inclusion of pregnant women in clinical trials has received
      renewed attention recently. This interest springs from articles in various
      medical journals highlighting the gaps in medical knowledge and the need to
      improve health care for pregnant women.It is not a simple decision whether to
      include pregnant women in studies or not. The general thought is that it's too
      dangerous for the baby if a pregnant woman is participating in a trial, and the
      absence of research on how medications work in pregnant women leave doctors
      guessing about how to safely and effectively treat patients through
      pregnancy.Excluding pregnant women from clinical trials are not automatic, not
      unethical nor is it arbitrarily determined. The regulatory framework is based on 
      sound ethical and legal reasoning that demonstrates when inclusion in a clinical 
      trial is appropriate or when clear and compelling reasons for exclusion are
      presented. LEARNING OBJECTIVE: Readers will learn about limitations of research, 
      history of the inclusion and exclusion of pregnant women in clinical trials,
      reticence for inclusions, as well as regulations designed using reasoned legal
      and ethical principles, such as: Principle of Autonomy, Informed Consent, and
      Beneficence and Nonmaleficence.
FAU - Allesee, Lori
AU  - Allesee L
AD  - Bioethics Research Intern, Saint Mary's University, USA.
FAU - Gallagher, Colleen M
AU  - Gallagher CM
LA  - eng
GR  - RC2 MD004764/MD/NIMHD NIH HHS/United States
GR  - RC2 MD004764-01/MD/NIMHD NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - J Clin Res Bioeth
JT  - Journal of clinical research & bioethics
JID - 101561039
PMC - PMC3158978
MID - NIHMS294082
EDAT- 2011/08/25 06:00
MHDA- 2011/08/25 06:01
CRDT- 2011/08/25 06:00
PHST- 2011/08/25 06:00 [entrez]
PHST- 2011/08/25 06:00 [pubmed]
PHST- 2011/08/25 06:01 [medline]
AID - 10.4172/2155-9627.1000108 [doi]
PST - ppublish
SO  - J Clin Res Bioeth. 2011 Mar 31;2(108). doi: 10.4172/2155-9627.1000108.


PMID- 21862825
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20220409
IS  - 1534-7796 (Electronic)
IS  - 0033-3174 (Linking)
VI  - 73
IP  - 7
DP  - 2011 Sep
TI  - The nocebo effect and its relevance for clinical practice.
PG  - 598-603
LID - 10.1097/PSY.0b013e3182294a50 [doi]
AB  - Negative expectations deriving from the clinical encounter can produce negative
      outcomes, known as nocebo effects. Specifically, research on the nocebo effect
      indicates that information disclosure about potential side effects can itself
      contribute to producing adverse effects. Neurobiological processes play a role in
      the nocebo effect, and this article provides a selective review of mechanistic
      research on the nocebo effect. Comparatively little attention has been directed
      to clinical studies and their implications for daily clinical practice. The
      nocebo response is influenced by the content and the way information is presented
      to patients in clinical trials in both the placebo and active treatment
      conditions. Nocebo effects adversely influence quality of life and therapy
      adherence, emphasizing the need for minimizing these responses to the extent
      possible. Evidence further indicates that the informed consent process in
      clinical trials may induce nocebo effects. This article concludes with ethical
      directions for future patient-oriented research and routine practice.
FAU - Colloca, Luana
AU  - Colloca L
AD  - Department of Bioethics, Clinical Center, National Institutes of Health, Bldg 10,
      Room 1C118, Bethesda, MD 20892-1156, USA. luana.colloca@nih.gov
FAU - Miller, Franklin G
AU  - Miller FG
LA  - eng
GR  - Z99 AT999999/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20110823
PL  - United States
TA  - Psychosom Med
JT  - Psychosomatic medicine
JID - 0376505
SB  - IM
MH  - *Anticipation, Psychological/physiology
MH  - *Drug-Related Side Effects and Adverse Reactions
MH  - Humans
MH  - Informed Consent
MH  - *Placebo Effect
PMC - PMC3167012
MID - NIHMS312016
EDAT- 2011/08/25 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/08/25 06:00
PHST- 2011/08/25 06:00 [entrez]
PHST- 2011/08/25 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - PSY.0b013e3182294a50 [pii]
AID - 10.1097/PSY.0b013e3182294a50 [doi]
PST - ppublish
SO  - Psychosom Med. 2011 Sep;73(7):598-603. doi: 10.1097/PSY.0b013e3182294a50. Epub
      2011 Aug 23.


PMID- 21862388
OWN - NLM
STAT- MEDLINE
DCOM- 20120120
LR  - 20181201
IS  - 1879-0593 (Electronic)
IS  - 1368-8375 (Linking)
VI  - 47
IP  - 10
DP  - 2011 Oct
TI  - Antitumor activity of cetuximab associated with the
      taxotere-cisplatin-fluorouracil (TPF) combination on an orthotopic head and neck 
      cancer model.
PG  - 940-5
LID - 10.1016/j.oraloncology.2011.07.028 [doi]
AB  - BACKGROUND: Cetuximab (Cet), an anti-epidermal growth factor receptor (EGFR)
      monoclonal antibody, is a standard of care in advanced head and neck (HN) cancer 
      when combined with irradiation or cisplatin. The TPF association combining
      docetaxel (T), cisplatin (P) and fluorouracil (F) has become a chemotherapy of
      reference in the management of HN tumors. The aim of the study was to evaluate
      the anti-tumor activity of the association of Cet with TPF. In addition, the
      potential benefit from adding bevacizumab (Bev), an anti-VEGF monoclonal
      antibody, was examined. METHODS: Investigations were performed on CAL33 human
      head and neck cancer cell line (high content of EGFR) injected as an orthotopic
      xenograft into the mouth floor of nude mice. The anti-tumor efficacy of Cet (2.5 
      mg/kg), Bev (20 mg/kg) and of TPF (at the MTD: T 20 mg/kg, P 6 mg/kg, F 17
      mg/kg), administered alone or in combination on day 3 and day 10 after tumor cell
      injection, was assessed on day 12 (animal sacrifice for ethical reasons, 10
      animals per treatment group). Tumor volume, tumor histology, tumor cell
      proliferation (Ki67, immunochemistry) and apoptosis (Bcl2, immunochemistry) were 
      examined. RESULTS: As compared to controls, TPF-Cet and TPF-Cet-Bev had a
      significant impact on tumor volume and histological response. The highest
      efficacy was observed with the TPF-Cet combination. The effects of the
      TPF-Cet-Bev association were not significantly different from those observed with
      TPF-Cet. Data were corroborated by a diminution in Ki67 labeling and Bcl2
      expression. CONCLUSION: The association of Cet with TPF can be considered a
      beneficial clinical option in advanced HN cancer patients.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Bozec, Alexandre
AU  - Bozec A
AD  - Surgery Department, Centre Antoine Lacassagne, 33 Av. de Valombrose, 06189 Nice
      Cedex 2, France.
FAU - Sudaka, Anne
AU  - Sudaka A
FAU - Etienne-Grimaldi, Marie-Christine
AU  - Etienne-Grimaldi MC
FAU - Brunstein, Marie-Christine
AU  - Brunstein MC
FAU - Fischel, Jean-Louis
AU  - Fischel JL
FAU - Milano, Gerard
AU  - Milano G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110908
PL  - England
TA  - Oral Oncol
JT  - Oral oncology
JID - 9709118
RN  - 0 (Angiogenesis Inhibitors)
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antibodies, Monoclonal, Humanized)
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Ki-67 Antigen)
RN  - 0 (Taxoids)
RN  - 15H5577CQD (Docetaxel)
RN  - 2S9ZZM9Q9V (Bevacizumab)
RN  - PQX0D8J21J (Cetuximab)
RN  - Q20Q21Q62J (Cisplatin)
RN  - U3P01618RT (Fluorouracil)
SB  - IM
MH  - Angiogenesis Inhibitors/*administration & dosage
MH  - Animals
MH  - Antibodies, Monoclonal/*administration & dosage
MH  - Antibodies, Monoclonal, Humanized/administration & dosage
MH  - Antineoplastic Agents/*administration & dosage
MH  - Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
MH  - Apoptosis/drug effects
MH  - Bevacizumab
MH  - Cell Line, Tumor
MH  - Cetuximab
MH  - Cisplatin/administration & dosage
MH  - Docetaxel
MH  - Drug Therapy, Combination/methods
MH  - Fluorouracil/administration & dosage
MH  - Head and Neck Neoplasms/*drug therapy/pathology
MH  - Humans
MH  - Ki-67 Antigen/metabolism
MH  - Mice
MH  - Mice, Nude
MH  - Taxoids/administration & dosage
MH  - Treatment Outcome
MH  - Xenograft Model Antitumor Assays
EDAT- 2011/08/25 06:00
MHDA- 2012/01/21 06:00
CRDT- 2011/08/25 06:00
PHST- 2011/05/30 00:00 [received]
PHST- 2011/07/25 00:00 [revised]
PHST- 2011/07/26 00:00 [accepted]
PHST- 2011/08/25 06:00 [entrez]
PHST- 2011/08/25 06:00 [pubmed]
PHST- 2012/01/21 06:00 [medline]
AID - S1368-8375(11)00769-X [pii]
AID - 10.1016/j.oraloncology.2011.07.028 [doi]
PST - ppublish
SO  - Oral Oncol. 2011 Oct;47(10):940-5. doi: 10.1016/j.oraloncology.2011.07.028. Epub 
      2011 Sep 8.


PMID- 21862138
OWN - NLM
STAT- MEDLINE
DCOM- 20120426
LR  - 20181201
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 136
IP  - 1-2
DP  - 2012 Jan
TI  - A randomized, single-blind, comparison of duloxetine with bupropion in the
      treatment of SSRI-resistant major depression.
PG  - 172-176
LID - S0165-0327(11)00453-8 [pii]
LID - 10.1016/j.jad.2011.07.026 [doi]
AB  - INTRODUCTION: For patients who continue to experience depressive symptoms despite
      an adequate antidepressant SSRI trial, across-class switch is considered one of
      the best treatment options. The goal of the present work was to compare in terms 
      of efficacy two different dual-action compounds, duloxetine and bupropion, in
      patients who failed to respond in two consecutive antidepressant trials with
      SSRIs. METHODS: The patients were allocated randomly to duloxetine (120 mg daily)
      or bupropion extended release (300 mg daily). The intended medication period was 
      6 weeks. The primary measure of efficacy was depressive symptoms severity.
      RESULTS: A total of 49 participants were randomly assigned to duloxetine 120 mg
      (n=27) or bupropion 300 mg (n=22). The ITT efficacy patient sample consisted of
      46 patients. Relatively high response and remission rates in treatment groups
      were found: from 60 to 70% of patients responded to treatment, and approximately 
      30 to 40% were in remission by the endpoint (week 6). No statistically
      significant difference emerged between the two groups at any post-baseline
      assessment, neither on mean scores of rating scales nor on qualitative efficacy
      measures. LIMITS: Limitations of the study are the lack of a placebo arm,
      difficult to include owing to ethical reasons, and the relatively small size of
      the sample. CONCLUSIONS: These preliminary results seem to support the hypothesis
      that in patients unresponsive to SSRIs the administration of antidepressants with
      different mechanisms of action is an effective switching strategy. Further
      studies are needed in light of the challenge posed by resistant depression.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Rosso, G
AU  - Rosso G
AD  - Mood and Anxiety Disorders Unit, Department of Neuroscience, University of Turin,
      Turin, Italy.
FAU - Rigardetto, S
AU  - Rigardetto S
AD  - Mood and Anxiety Disorders Unit, Department of Neuroscience, University of Turin,
      Turin, Italy.
FAU - Bogetto, F
AU  - Bogetto F
AD  - Mood and Anxiety Disorders Unit, Department of Neuroscience, University of Turin,
      Turin, Italy.
FAU - Maina, G
AU  - Maina G
AD  - Mood and Anxiety Disorders Unit, Department of Neuroscience, University of Turin,
      Turin, Italy. Electronic address: giuseppemaina@hotmail.com.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20110820
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
RN  - 0 (Antidepressive Agents)
RN  - 0 (Thiophenes)
RN  - 01ZG3TPX31 (Bupropion)
RN  - 9044SC542W (Duloxetine Hydrochloride)
SB  - IM
MH  - Adult
MH  - Antidepressive Agents/*therapeutic use
MH  - Bupropion/*therapeutic use
MH  - Depressive Disorder, Major/*drug therapy
MH  - Duloxetine Hydrochloride
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Single-Blind Method
MH  - Thiophenes/*therapeutic use
EDAT- 2011/08/25 06:00
MHDA- 2012/04/27 06:00
CRDT- 2011/08/25 06:00
PHST- 2011/04/27 00:00 [received]
PHST- 2011/07/27 00:00 [revised]
PHST- 2011/07/27 00:00 [accepted]
PHST- 2011/08/25 06:00 [entrez]
PHST- 2011/08/25 06:00 [pubmed]
PHST- 2012/04/27 06:00 [medline]
AID - S0165-0327(11)00453-8 [pii]
AID - 10.1016/j.jad.2011.07.026 [doi]
PST - ppublish
SO  - J Affect Disord. 2012 Jan;136(1-2):172-176. doi: 10.1016/j.jad.2011.07.026. Epub 
      2011 Aug 20.


PMID- 21861944
OWN - NLM
STAT- MEDLINE
DCOM- 20120523
LR  - 20181201
IS  - 1741-203X (Electronic)
IS  - 1041-6102 (Linking)
VI  - 24
IP  - 3
DP  - 2012 Mar
TI  - Sexuality in institutionalized elderly persons: a systematic review of
      argument-based ethics literature.
PG  - 346-57
LID - 10.1017/S1041610211001542 [doi]
AB  - BACKGROUND: Admission to a nursing home might challenge the way in which
      individuals experience their own sexuality, but it does not automatically
      diminish their need and desire for sexual fulfillment. Despite the fact that
      sexuality proves to be an intrinsic part of human existence, the sexual
      expression of geriatric residents remains a sensitive subject for many caregivers
      and family members. It evokes a variety of ethical issues and concerns,
      especially when dementia patients are involved. The overall objective of this
      review was to examine the ethical arguments and concepts about the debate on
      sexuality within a nursing home environment. METHODS: We conducted a systematic
      search for argument-based ethics literature focusing on sexuality in
      institutionalized elderly people. Twenty-five appropriate studies were
      identified. RESULTS: A thematic analysis of the included literature led us to
      distinguish two major groups of ethical arguments: (i) principles and (ii) care. 
      Ethics arguments on sexuality in institutionalized elderly are particularly
      guided by the principle of respect for autonomy and the concomitant notion of
      informed consent. Arguments related to care were also apparent within the
      research literature although they received considerably less attention than the
      arguments related to the principles of respect for autonomy, beneficence,
      nonmaleficence and justice. CONCLUSIONS: The lack of clarity in the
      conceptualization of the arguments referred to in the research literature
      indicates that there is a pressing need for a better defined, more fundamental
      philosophical-ethical analysis of the values at stake.
FAU - Mahieu, Lieslot
AU  - Mahieu L
AD  - Centre for Biomedical Ethics and Law, Faculty of Medicine, Catholic University of
      Leuven, Leuven, Belgium. lieslot.mahieu@med.kuleuven.be
FAU - Gastmans, Chris
AU  - Gastmans C
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20110824
PL  - England
TA  - Int Psychogeriatr
JT  - International psychogeriatrics
JID - 9007918
SB  - IM
MH  - Aged
MH  - Alzheimer Disease/*nursing/*psychology
MH  - Belgium
MH  - Beneficence
MH  - *Ethics, Institutional
MH  - Female
MH  - Homes for the Aged/*ethics
MH  - Humans
MH  - Informed Consent/ethics
MH  - Male
MH  - Nursing Homes/*ethics
MH  - Personal Autonomy
MH  - Sexual Behavior/ethics
MH  - *Sexuality
MH  - Social Justice/ethics
MH  - Social Values
EDAT- 2011/08/25 06:00
MHDA- 2012/05/24 06:00
CRDT- 2011/08/25 06:00
PHST- 2011/08/25 06:00 [entrez]
PHST- 2011/08/25 06:00 [pubmed]
PHST- 2012/05/24 06:00 [medline]
AID - S1041610211001542 [pii]
AID - 10.1017/S1041610211001542 [doi]
PST - ppublish
SO  - Int Psychogeriatr. 2012 Mar;24(3):346-57. doi: 10.1017/S1041610211001542. Epub
      2011 Aug 24.


PMID- 21861909
OWN - NLM
STAT- MEDLINE
DCOM- 20120123
LR  - 20211020
IS  - 1471-2377 (Electronic)
IS  - 1471-2377 (Linking)
VI  - 11
DP  - 2011 Aug 23
TI  - Effects of shared medical appointments on quality of life and cost-effectiveness 
      for patients with a chronic neuromuscular disease. Study protocol of a randomized
      controlled trial.
PG  - 106
LID - 10.1186/1471-2377-11-106 [doi]
AB  - BACKGROUND: Shared medical appointments are a series of one-to-one doctor-patient
      contacts, in presence of a group of 6-10 fellow patients. This group visits
      substitute the annual control visits of patients with the neurologist. The same
      items attended to in a one-to-one appointment are addressed. The possible
      advantages of a shared medical appointment could be an added value to the present
      management of neuromuscular patients. The currently problem-focused one-to-one
      out-patient visits often leave little time for the patient's psychosocial needs, 
      patient education, and patient empowerment. METHODS/DESIGN: A randomized,
      prospective controlled study (RCT) with a follow up of 6 months will be conducted
      to evaluate the clinical and cost-effectiveness of shared medical appointments
      compared to usual care for 300 neuromuscular patients and their partners at the
      Radboud University Nijmegen Medical Center. Every included patient will be
      randomly allocated to one of the two study arms. This study has been reviewed and
      approved by the medical ethics committee of the region Arnhem-Nijmegen, The
      Netherlands. The primary outcome measure is quality of life as measured by the
      EQ-5D, SF-36 and the Individualized neuromuscular Quality of Life Questionnaire. 
      The primary analysis will be an intention-to-treat analysis on the area under the
      curve of the quality of life scores. A linear mixed model will be used with
      random factor group and fixed factors treatment, baseline score and type of
      neuromuscular disease. For the economic evaluation an incremental
      cost-effectiveness analysis will be conducted from a societal perspective,
      relating differences in costs to difference in health outcome. Results are
      expected in 2012. DISCUSSION: This study will be the first randomized controlled 
      trial which evaluates the effect of shared medical appointments versus usual care
      for neuromuscular patients. This will enable to determine if there is additional 
      value of shared medical appointments to the current therapeutical spectrum. When 
      this study shows that group visits produce the alleged benefits, this may help to
      increase the acceptance of this innovative and creative way of using one of the
      most precious resources in health care more efficiently: time. TRIAL
      REGISTRATION: DutchTrial Register http://www.trialregister.nlNTR1412.
FAU - Seesing, Femke M
AU  - Seesing FM
AD  - Department of Neurology, Radboud University Nijmegen Medical Center, Reinier
      Postlaan 4, Nijmegen, The Netherlands.
FAU - Drost, Gea
AU  - Drost G
FAU - van der Wilt, Gert-Jan
AU  - van der Wilt GJ
FAU - van Engelen, Baziel G M
AU  - van Engelen BG
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110823
PL  - England
TA  - BMC Neurol
JT  - BMC neurology
JID - 100968555
SB  - IM
MH  - *Appointments and Schedules
MH  - Caregivers/psychology/statistics & numerical data
MH  - Clinical Protocols
MH  - Cost-Benefit Analysis/*methods
MH  - Health Care Costs/statistics & numerical data
MH  - Humans
MH  - Intention to Treat Analysis
MH  - Neuromuscular Diseases/*economics/nursing/*psychology
MH  - Outcome Assessment, Health Care/statistics & numerical data
MH  - Quality of Life/*psychology
PMC - PMC3178478
EDAT- 2011/08/25 06:00
MHDA- 2012/01/24 06:00
CRDT- 2011/08/25 06:00
PHST- 2011/06/15 00:00 [received]
PHST- 2011/08/23 00:00 [accepted]
PHST- 2011/08/25 06:00 [entrez]
PHST- 2011/08/25 06:00 [pubmed]
PHST- 2012/01/24 06:00 [medline]
AID - 1471-2377-11-106 [pii]
AID - 10.1186/1471-2377-11-106 [doi]
PST - epublish
SO  - BMC Neurol. 2011 Aug 23;11:106. doi: 10.1186/1471-2377-11-106.


PMID- 21861876
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20220318
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 12
DP  - 2011 Aug 23
TI  - Saudi mothers' preferences about breaking bad news concerning newborns: a
      structured verbal questionnaire.
PG  - 15
LID - 10.1186/1472-6939-12-15 [doi]
AB  - BACKGROUND: Breaking bad news (BBN) to parents whose newborn has a major disease 
      is an ethical dilemma. In Saudi Arabia, BBN about newborns is performed according
      to the parental preferences that have been reported from non-Arabic/non-Islamic
      countries. Saudi mothers' preferences about BBN have not yet been studied.
      Therefore, we aimed to elicit the preferences of Saudi mothers about BBN
      concerning newborns. METHODS: We selected a convenience sample of 402 Saudi
      mothers, aged 18-50 years, who had no previous experience with BBN. We selected
      them via a simple number-randomization scheme from the premises of a level III
      Saudi hospital between October of 2009 and January of 2011. We used a
      hypothetical situation (BBN about trisomy 21) to elicit their preferences about
      BBN concerning newborns via a structured verbal questionnaire composed of 12
      multiple-choice questions. We expressed their preferences as percentages (95%
      confidence interval), and we used the Kendall's W test (W) to assess the degree
      of agreement in preferences. RESULTS: The Saudi mothers preferred that BBN be
      conducted with both parents together (64% [60-69]), albeit with weak levels of
      agreement (W = 0.29). They showed moderate agreement in their preferences that
      BBN should be conducted early (79% [75-83], W = 0.48), in detail (81% [77-85], W 
      = 0.52), in person (88% [85-91], W = 0.58), and in a quiet setting (86% [83-90], 
      W = 0.53). With extremely weak agreement, they preferred to have a known person
      present for support during BBN (56% [51-61], W = 0.01), to have close bodily
      contact with their babies (66% [61-70], W = 0.10), and to have no another
      patients present (64% [59-68], W = 0.08). They showed moderate levels of
      agreement in their desires to detail, in advance, their preferences about process
      of BBN by giving a reversible, written informed consent that could be utilized
      for guidance, if needed (80% [76-84], W = 0.36). CONCLUSIONS: In our experience, 
      Saudi mothers' preferences about BBN concerning newborns are varied, suggesting
      that a "one-size-fits-all" approach is inappropriate. A reversible, written
      informed consent detailing their preferences about BBN that would be kept in
      their medical records and utilized for guidance, if needed, may be the best
      solution, given this level of diversity. These findings merit further study.
FAU - Al-Abdi, Sameer Y
AU  - Al-Abdi SY
AD  - Department of Pediatrics, King Abdulaziz Hospital, Al-Ahsa, Saudi Arabia.
      abdis@ngha.med.sa
FAU - Al-Ali, Eman A
AU  - Al-Ali EA
FAU - Daheer, Matar H
AU  - Daheer MH
FAU - Al-Saleh, Yaseen M
AU  - Al-Saleh YM
FAU - Al-Qurashi, Khalid H
AU  - Al-Qurashi KH
FAU - Al-Aamri, Maryam A
AU  - Al-Aamri MA
LA  - eng
PT  - Journal Article
DEP - 20110823
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Adult
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - *Infant, Newborn, Diseases
MH  - Middle Aged
MH  - Mothers/psychology/*statistics & numerical data
MH  - *Physician-Patient Relations/ethics
MH  - Sampling Studies
MH  - Saudi Arabia
MH  - Social Support
MH  - Surveys and Questionnaires
MH  - *Truth Disclosure/ethics
PMC - PMC3175465
EDAT- 2011/08/25 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/08/25 06:00
PHST- 2011/04/04 00:00 [received]
PHST- 2011/08/23 00:00 [accepted]
PHST- 2011/08/25 06:00 [entrez]
PHST- 2011/08/25 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - 1472-6939-12-15 [pii]
AID - 10.1186/1472-6939-12-15 [doi]
PST - epublish
SO  - BMC Med Ethics. 2011 Aug 23;12:15. doi: 10.1186/1472-6939-12-15.


PMID- 21860978
OWN - NLM
STAT- MEDLINE
DCOM- 20120206
LR  - 20210305
IS  - 1808-8686 (Electronic)
IS  - 1808-8686 (Linking)
VI  - 77
IP  - 4
DP  - 2011 Jul-Aug
TI  - Auditory processing performance in blind people.
PG  - 504-509
LID - S1808-8694(15)30685-6 [pii]
LID - 10.1590/S1808-86942011000400015 [doi]
AB  - UNLABELLED: Hearing has an important role in human development and social
      adaptation in blind people. OBJECTIVE: To evaluate the performance of temporal
      auditory processing in blind people; to characterize the temporal resolution
      ability; to characterize the temporal ordinance ability and to compare the
      performance of the study population in the applied tests. METHODS: Fifteen blind 
      adults participated in this study. A cross-sectional study was undertaken;
      approval was obtained from the Pernambuco Catholic University Ethics Committee,
      no. 003/2008. RESULTS: Temporal auditory processing was excellent--the average
      composed threshold in the original RGDT version was 4. 98 ms; it was 50 ms for
      all frequencies in the expanded version. PPS and DPS results ranged from 95% to
      100%. There were no quantitative differences in the comparison of tests; but oral
      reports suggested that the original RGDT original version was more difficult.
      CONCLUSIONS: The study sample performed well in temporal auditory processing; it 
      also performed well in temporal resolution and ordinance abilities.
FAU - Boas, Ludmilla Vilas
AU  - Boas LV
AD  - Doctoral student in cognitive psychology, UFPE. Speech therapist.
FAU - Muniz, Lilian
AU  - Muniz L
AD  - Doctoral degree in cognitive psychology, UFPE. Adjunct professor at the UFPE.
FAU - da Silva Caldas Neto, Silvio
AU  - da Silva Caldas Neto S
AD  - Senior Associate Professor - FMUSP. Adjunct professor, UFPE.
FAU - Gouveia, Mariana de Carvalho Leal
AU  - Gouveia MCL
AD  - Doctoral degree in sciences - otorhinolaryngology. Adjunct professor of
      otorhinolaryngology at the UFPE. Head of the Otorhinolaryngology Unit of the
      Agamenon Magalhaes Hospital.
LA  - eng
LA  - por
PT  - Journal Article
PL  - Brazil
TA  - Braz J Otorhinolaryngol
JT  - Brazilian journal of otorhinolaryngology
JID - 101207337
SB  - IM
MH  - Acoustic Stimulation/methods
MH  - Adolescent
MH  - Adult
MH  - Auditory Perception/*physiology
MH  - Auditory Threshold/physiology
MH  - Blindness/*physiopathology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Hearing Tests/*methods
MH  - Humans
MH  - Male
EDAT- 2011/08/24 06:00
MHDA- 2012/02/07 06:00
CRDT- 2011/08/24 06:00
PHST- 2010/08/15 00:00 [received]
PHST- 2010/12/01 00:00 [accepted]
PHST- 2011/08/24 06:00 [entrez]
PHST- 2011/08/24 06:00 [pubmed]
PHST- 2012/02/07 06:00 [medline]
AID - S1808-8694(15)30685-6 [pii]
AID - 10.1590/S1808-86942011000400015 [doi]
PST - ppublish
SO  - Braz J Otorhinolaryngol. 2011 Jul-Aug;77(4):504-509. doi:
      10.1590/S1808-86942011000400015.


PMID- 21860933
OWN - NLM
STAT- MEDLINE
DCOM- 20111230
LR  - 20181201
IS  - 1806-9339 (Electronic)
IS  - 0100-7203 (Linking)
VI  - 33
IP  - 5
DP  - 2011 May
TI  - [Strategies directed to professionals for reducing unnecessary cesarean sections 
      in Brazil].
PG  - 252-62
LID - S0100-72032011000500008 [pii]
AB  - Brazil is among the countries with the highest cesarean section rates, especially
      in the supplementary health sector. However, some characteristics are similar in 
      both the public and private sectors in terms of the wishes and expectations of
      pregnant women regarding their delivery. There is a preference for vaginal
      delivery among women of all social, economic, and cultural levels, a fact that
      shifts the focus of the negative influence of this variable from women to other
      subjects involved in delivery care. No isolated factor is able to justify the
      complexity of making a decision for cesarean section, but the physician and the
      type of hospital are the main associated factors. The several harmful effects of 
      a non-judicious performance of cesarean section are scientifically recognized. It
      is important to raise the awareness of doctors and of other health professionals 
      about the real consequences of this decision, the ethical deviations when
      conducts are chosen without exclusively focusing on the patient`s health, and the
      need for constant updating for the management of the various possible conditions 
      of childbirth.
FAU - Haddad, Samira El Maerrawi T
AU  - Haddad SM
AD  - Centro de Atencao Integral a Saude da Mulher, Universidade Estadual de Campinas, 
      Campinas, SP, Brasil.
FAU - Cecatti, Jose Guilherme
AU  - Cecatti JG
LA  - por
PT  - Journal Article
PT  - Review
TT  - Estrategias dirigidas aos profissionais para a reducao das cesareas
      desnecessarias no Brasil.
PL  - Brazil
TA  - Rev Bras Ginecol Obstet
JT  - Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira
      das Sociedades de Ginecologia e Obstetricia
JID - 9214757
SB  - IM
MH  - Brazil
MH  - Cesarean Section/*statistics & numerical data
MH  - Female
MH  - Humans
MH  - Practice Guidelines as Topic
MH  - *Practice Patterns, Physicians'
MH  - Pregnancy
MH  - Unnecessary Procedures/*statistics & numerical data
EDAT- 2011/08/24 06:00
MHDA- 2011/12/31 06:00
CRDT- 2011/08/24 06:00
PHST- 2011/04/28 00:00 [received]
PHST- 2011/06/27 00:00 [accepted]
PHST- 2011/08/24 06:00 [entrez]
PHST- 2011/08/24 06:00 [pubmed]
PHST- 2011/12/31 06:00 [medline]
AID - S0100-72032011000500008 [pii]
PST - ppublish
SO  - Rev Bras Ginecol Obstet. 2011 May;33(5):252-62.


PMID- 21860275
OWN - NLM
STAT- MEDLINE
DCOM- 20111220
LR  - 20110823
IS  - 1539-073X (Electronic)
IS  - 1520-9229 (Linking)
VI  - 13
IP  - 3
DP  - 2011 Jul-Sep
TI  - Use of digital health records raises ethics concerns.
PG  - 84-9; quiz 90-1
LID - 10.1097/NHL.0b013e31822aafbd [doi]
AB  - There has been a proliferation in the use of digital health records. Although
      electronic records have many benefits, concerns have been raised about associated
      risks and barriers. This article focuses on risks associated with development,
      utilization, and maintenance of provider-owned electronic medical records and
      institution-owned electronic health records. Strategies to reduce risks and
      overcome barriers are also offered. Attention to these issues can minimize risks 
      and improve healthcare services delivered to consumers.
FAU - Kopala, Beverly
AU  - Kopala B
AD  - Niehoff School of Nursing, Loyola University Chicago, Chicago, IL, USA.
      bkopala@luc.edu
FAU - Mitchell, Mary Ellen
AU  - Mitchell ME
LA  - eng
PT  - Journal Article
PL  - United States
TA  - JONAS Healthc Law Ethics Regul
JT  - JONA'S healthcare law, ethics and regulation
JID - 100888423
MH  - Confidentiality/*ethics
MH  - Electronic Health Records/*ethics
MH  - Hospital Records/*legislation & jurisprudence
MH  - Humans
MH  - Privacy
MH  - Risk Factors
MH  - United States
EDAT- 2011/08/24 06:00
MHDA- 2011/12/21 06:00
CRDT- 2011/08/24 06:00
PHST- 2011/08/24 06:00 [entrez]
PHST- 2011/08/24 06:00 [pubmed]
PHST- 2011/12/21 06:00 [medline]
AID - 10.1097/NHL.0b013e31822aafbd [doi]
AID - 00128488-201107000-00004 [pii]
PST - ppublish
SO  - JONAS Healthc Law Ethics Regul. 2011 Jul-Sep;13(3):84-9; quiz 90-1. doi:
      10.1097/NHL.0b013e31822aafbd.


PMID- 21860274
OWN - NLM
STAT- MEDLINE
DCOM- 20111220
LR  - 20110823
IS  - 1539-073X (Electronic)
IS  - 1520-9229 (Linking)
VI  - 13
IP  - 3
DP  - 2011 Jul-Sep
TI  - Conflicting voices: Withhold treatment or not for a patient with chronic
      self-destructive behavior?
PG  - 79-83
LID - 10.1097/NHL.0b013e31822ab019 [doi]
AB  - Patients with a history of chronic self-destructive and self-injurious behavior
      present many difficulties to healthcare providers. These patients often have
      related substance abuse and personality disorders that complicate their medical
      care. Treatment encounters initially may be related to medical treatment of
      episodic substance intoxicated states with or without self-inflicted injuries.
      Patients later can develop comorbid medical illnesses associated with
      nonadherence of treatment or iatrogenic conditions, both of which result in
      complex end-of-life-care decisions. Institutional familiarity of repeat patients 
      often leaves healthcare providers feeling responsible for the patient despite
      having little influence over the patients' ultimate behavioral outcomes. This
      article describes a patient with chronic alcohol abuse, treatment noncompliance, 
      severe personality disorder, recurrent suicidal ideation, self-injurious
      behavior, alcoholic cirrhosis, and suicide attempt resulting in multisystem
      injuries leading to an ethical conflict regarding end-of-life care.
FAU - Badger, James M
AU  - Badger JM
AD  - Department of Nursing, Rhode Island Hospital, Providence, Rhode Island, USA.
      Jbadger@lifespan.org
FAU - Ekman Ladd, Rosalind
AU  - Ekman Ladd R
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - JONAS Healthc Law Ethics Regul
JT  - JONA'S healthcare law, ethics and regulation
JID - 100888423
MH  - Adult
MH  - Chronic Disease
MH  - Humans
MH  - Male
MH  - *Self-Injurious Behavior
MH  - Terminal Care/*ethics
MH  - Treatment Refusal
MH  - Withholding Treatment/*ethics
EDAT- 2011/08/24 06:00
MHDA- 2011/12/21 06:00
CRDT- 2011/08/24 06:00
PHST- 2011/08/24 06:00 [entrez]
PHST- 2011/08/24 06:00 [pubmed]
PHST- 2011/12/21 06:00 [medline]
AID - 10.1097/NHL.0b013e31822ab019 [doi]
AID - 00128488-201107000-00003 [pii]
PST - ppublish
SO  - JONAS Healthc Law Ethics Regul. 2011 Jul-Sep;13(3):79-83. doi:
      10.1097/NHL.0b013e31822ab019.


PMID- 21859182
OWN - NLM
STAT- MEDLINE
DCOM- 20120116
LR  - 20181201
IS  - 1939-1455 (Electronic)
IS  - 0033-2909 (Linking)
VI  - 137
IP  - 5
DP  - 2011 Sep
TI  - Genetics and human agency: comment on Dar-Nimrod and Heine (2011).
PG  - 825-8
LID - 10.1037/a0024306 [doi]
AB  - Dar-Nimrod and Heine (2011) decried genetic essentialism without denying the
      importance of genetics in the genesis of human behavior, and although I agree on 
      both counts, a deeper issue remains unaddressed: how should we adjust our
      cognitions about our own behavior in light of genetic influence, or is it perhaps
      not necessary to take genetics into account at all? I suggest that the genetics
      of behavior does have important implications for how we understand ourselves, the
      differences among us, and the ethical implications of our actions, but that the
      usual metric for these considerations, the heritability coefficient, is not the
      correct one. I propose an alternative.
CI  - (PsycINFO Database Record (c) 2011 APA, all rights reserved).
FAU - Turkheimer, Eric
AU  - Turkheimer E
AD  - Department of Psychology, University of Virginia, Charlottesville, VA 22904-4400,
      USA. eric.turkheimer@gmail.com
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Psychol Bull
JT  - Psychological bulletin
JID - 0376473
SB  - IM
CON - Psychol Bull. 2011 Sep;137(5):800-18. PMID: 21142350
CIN - Psychol Bull. 2011 Sep;137(5):829-33. PMID: 21859183
MH  - Female
MH  - *Genetic Determinism
MH  - Humans
MH  - Male
EDAT- 2011/08/24 06:00
MHDA- 2012/01/17 06:00
CRDT- 2011/08/24 06:00
PHST- 2011/08/24 06:00 [entrez]
PHST- 2011/08/24 06:00 [pubmed]
PHST- 2012/01/17 06:00 [medline]
AID - 2011-18633-009 [pii]
AID - 10.1037/a0024306 [doi]
PST - ppublish
SO  - Psychol Bull. 2011 Sep;137(5):825-8. doi: 10.1037/a0024306.


PMID- 21839884
OWN - NLM
STAT- MEDLINE
DCOM- 20111014
LR  - 20220408
IS  - 1524-4733 (Electronic)
IS  - 1098-3015 (Linking)
VI  - 14
IP  - 5 Suppl 1
DP  - 2011 Jul-Aug
TI  - Influence of organic and functional dyspepsia on work productivity: the
      HEROES-DIP study.
PG  - S126-9
LID - 10.1016/j.jval.2011.05.021 [doi]
AB  - OBJECTIVES: Dyspepsia is defined as persistent or recurrent abdominal pain or
      discomfort centered in the upper abdomen. Dyspepsia represents up to 8.3% of all 
      primary care physician visits and causes huge economic costs to patients and to
      the economy as a whole. The aim of this study was to measure the influence of
      dyspepsia on work productivity of people within the Brazilian workforce. METHODS:
      Adult patients were enrolled if they met the Roma III criteria for uninvestigated
      dyspepsia. All patients answered a demographic questionnaire. Productivity
      impairment was measured by the Work Productivity and Activity Impairment
      questionnaire. Subjects underwent upper gastrointestinal endoscopy and were
      classified as having functional or organic dyspepsia. The study protocol was
      approved by the Ethics Committee of Hospital de Clinicas de Porto Alegre, Brazil.
      RESULTS: Eight hundred fifty patients with dyspepsia were evaluated: 628 were
      women (73.9%); mean age was 46.4 +/- 12.9 years; 387 (45.5%) were active workers.
      Among active workers, 32.2% mentioned that dyspepsia had caused absenteeism from 
      work during the preceding week and 78% reported a reduction of the work
      productivity (presenteeism). The lost work productivity score was 35.7% among all
      employed patients. The affect on work productivity was similar between patients
      with functional or organic dyspepsia. CONCLUSIONS: Our study showed an important 
      influence of dyspepsia on work productivity. We did not find any statistically
      significant difference on the influence on work between patients with organic
      dyspepsia and functional dyspepsia. The social impact of these findings is
      underscored by taking into account the prevalence (up to 40%) of this condition
      in Brazil.
CI  - Copyright (c) 2011 International Society for Pharmacoeconomics and Outcomes
      Research (ISPOR). Published by Elsevier Inc. All rights reserved.
FAU - Sander, Guilherme Becker
AU  - Sander GB
AD  - Universidade Federal do Rio Grande do Sul, School of Medicine, Programa de
      Pos-graduacao: Ciencias em Gastroenterologia e Hepatologia, Porto Alegre, Brazil.
      gbsander@gmail.com
FAU - Mazzoleni, Luiz Edmundo
AU  - Mazzoleni LE
FAU - Francesconi, Carlos Ferrnando de Magalhaes
AU  - Francesconi CF
FAU - Balbinotto, Giacomo
AU  - Balbinotto G
FAU - Mazzoleni, Felipe
AU  - Mazzoleni F
FAU - Wortmann, Andre Castagna
AU  - Wortmann AC
FAU - Cardoso, Israel de Quadros
AU  - Cardoso Ide Q
FAU - Klamt, Alexandre Luis
AU  - Klamt AL
FAU - Milbradt, Tobias Cancian
AU  - Milbradt TC
CN  - Helicobacter Eradication Relief of Dyspetic Symptoms Trial Investigators
LA  - eng
SI  - ClinicalTrials.gov/NCT00404534
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Value Health
JT  - Value in health : the journal of the International Society for Pharmacoeconomics 
      and Outcomes Research
JID - 100883818
SB  - IM
MH  - *Absenteeism
MH  - Activities of Daily Living
MH  - Adult
MH  - Brazil/epidemiology
MH  - Cost of Illness
MH  - Double-Blind Method
MH  - Dyspepsia/diagnosis/*economics/epidemiology/etiology
MH  - *Efficiency
MH  - Employment/*economics
MH  - Endoscopy, Gastrointestinal
MH  - Female
MH  - Gross Domestic Product
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Severity of Illness Index
MH  - Surveys and Questionnaires
EDAT- 2011/08/24 06:00
MHDA- 2011/10/15 06:00
CRDT- 2011/08/16 06:00
PHST- 2011/08/16 06:00 [entrez]
PHST- 2011/08/24 06:00 [pubmed]
PHST- 2011/10/15 06:00 [medline]
AID - S1098-3015(11)01437-9 [pii]
AID - 10.1016/j.jval.2011.05.021 [doi]
PST - ppublish
SO  - Value Health. 2011 Jul-Aug;14(5 Suppl 1):S126-9. doi: 10.1016/j.jval.2011.05.021.


PMID- 21858724
OWN - NLM
STAT- MEDLINE
DCOM- 20120222
LR  - 20211020
IS  - 1573-8744 (Electronic)
IS  - 1567-567X (Linking)
VI  - 38
IP  - 5
DP  - 2011 Oct
TI  - Modelling of the outcome of non-inferiority trials by integration of historical
      data.
PG  - 595-612
LID - 10.1007/s10928-011-9210-8 [doi]
AB  - The approval and differentiation of new compounds in clinical development often
      demands non-inferiority trials, in which the test drug is compared against a
      reference treatment. However, non-inferiority trials impose major operational
      burden with serious ethical and scientific implications for the development of
      new medicines. Traditional approaches make limited use of historical information 
      on placebo and neglect inter-trial variability, relying on the constancy
      assumption that the control-to-placebo effect size is maintained across trials.
      We propose a model-based approach that overcomes such limitations and may be used
      as a tool to explore differentiation during clinical development. Parameter
      distributions are introduced which reflect the heterogeneity of trials. The
      method is illustrated using data from impetigo trials. Based on simulation
      scenarios, this Bayesian technique yields a definitive, consistent increase in
      the statistical power over two accepted statistical methods, allowing lower
      sample size requirements for the assessment of non-inferiority.
FAU - Russu, Alberto
AU  - Russu A
AD  - Department of Computer Engineering and Systems Science, University of Pavia,
      Pavia, Italy.
FAU - van Zwet, Erik
AU  - van Zwet E
FAU - De Nicolao, Giuseppe
AU  - De Nicolao G
FAU - Della Pasqua, Oscar
AU  - Della Pasqua O
LA  - eng
PT  - Journal Article
DEP - 20110821
PL  - United States
TA  - J Pharmacokinet Pharmacodyn
JT  - Journal of pharmacokinetics and pharmacodynamics
JID - 101096520
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Placebos)
RN  - 59XE10C19C (Fusidic Acid)
SB  - IM
MH  - Anti-Bacterial Agents/pharmacokinetics/*therapeutic use
MH  - *Bayes Theorem
MH  - *Clinical Trials as Topic
MH  - Clinical Trials, Phase III as Topic
MH  - Databases, Factual
MH  - Double-Blind Method
MH  - Fusidic Acid/pharmacokinetics/*therapeutic use
MH  - Humans
MH  - Impetigo/*drug therapy
MH  - Placebos
MH  - *Research Design
MH  - Sample Size
MH  - *Software
MH  - Treatment Outcome
PMC - PMC3172410
EDAT- 2011/08/23 06:00
MHDA- 2012/02/23 06:00
CRDT- 2011/08/23 06:00
PHST- 2011/04/03 00:00 [received]
PHST- 2011/07/23 00:00 [accepted]
PHST- 2011/08/23 06:00 [entrez]
PHST- 2011/08/23 06:00 [pubmed]
PHST- 2012/02/23 06:00 [medline]
AID - 10.1007/s10928-011-9210-8 [doi]
PST - ppublish
SO  - J Pharmacokinet Pharmacodyn. 2011 Oct;38(5):595-612. doi:
      10.1007/s10928-011-9210-8. Epub 2011 Aug 21.


PMID- 21858620
OWN - NLM
STAT- MEDLINE
DCOM- 20111229
LR  - 20171116
IS  - 0035-1776 (Print)
IS  - 0035-1776 (Linking)
VI  - 132
IP  - 3
DP  - 2011
TI  - [The ethics of ethnography revisited: learning from documentaries].
PG  - 325-49
LID - 10.1007/s11873-011-0162-3 [doi]
AB  - This article offers a comparison of the legal suits filed by the interviewees
      against the director of the documentary Etre et avoir (to have and to be) with
      the rights of interviewees in ethnographic investigations, focusing particularly 
      on image copyrights and labor law. To say that interviewees contribute to such
      investigations in anonymity does not solve the main problem - they are crucial to
      the investigation, marginal to the analysis, and then are assigned no publication
      credits. While information about the interviewees should remain confidential,
      this article argues, that contribution and role in the making of a publication
      should not be ignored.
FAU - Weber, Florence
AU  - Weber F
AD  - florence.weber@ens.fr
LA  - fre
PT  - Journal Article
TT  - La deontologie ethnographique a l'epreuve du documentaire.
PL  - France
TA  - Rev Synth
JT  - Revue de synthese
JID - 8711586
MH  - Anthropology, Cultural/*ethics/legislation & jurisprudence
MH  - Copyright/legislation & jurisprudence
MH  - France
MH  - Humans
MH  - Motion Pictures/ethics/legislation & jurisprudence
EDAT- 2011/08/23 06:00
MHDA- 2011/12/30 06:00
CRDT- 2011/08/23 06:00
PHST- 2011/08/23 06:00 [entrez]
PHST- 2011/08/23 06:00 [pubmed]
PHST- 2011/12/30 06:00 [medline]
AID - 10.1007/s11873-011-0162-3 [doi]
PST - ppublish
SO  - Rev Synth. 2011;132(3):325-49. doi: 10.1007/s11873-011-0162-3.


PMID- 21858476
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20211020
IS  - 1573-0980 (Electronic)
IS  - 1386-7415 (Linking)
VI  - 32
IP  - 5
DP  - 2011 Oct
TI  - Comradery, community, and care in military medical ethics.
PG  - 337-50
LID - 10.1007/s11017-011-9189-6 [doi]
AB  - Medical ethics prohibits caregivers from discriminating and providing
      preferential care to their compatriots and comrades. In military medicine,
      particularly during war and when resources may be scarce, ethical principles may 
      dictate priority care for compatriot soldiers. The principle of nondiscrimination
      is central to utilitarian and deontological theories of justice, but
      communitarianism and the ethics of care and friendship stipulate a different set 
      of duties for community members, friends, and family. Similar duties exist among 
      the small cohesive groups that typify many military units. When members of these 
      groups require medical care, there are sometimes moral grounds to treat
      compatriot soldiers ahead of enemy or allied soldiers regardless of the severity 
      of their respective wounds.
FAU - Gross, Michael L
AU  - Gross ML
AD  - School of Political Sciences, The University of Haifa, Mt. Carmel, Haifa, Israel.
      mgross@poli.haifa.ac.il
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Theor Med Bioeth
JT  - Theoretical medicine and bioethics
JID - 9805378
SB  - IM
MH  - Caregivers/ethics
MH  - Delivery of Health Care/*ethics
MH  - Ethical Theory
MH  - Ethics, Medical
MH  - Family
MH  - Friends
MH  - Health Services Needs and Demand
MH  - Humans
MH  - *Mass Behavior
MH  - Military Medicine/*ethics
MH  - *Moral Obligations
MH  - *Patient Rights
MH  - *Social Justice
MH  - *Social Responsibility
EDAT- 2011/08/23 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/08/23 06:00
PHST- 2011/08/23 06:00 [entrez]
PHST- 2011/08/23 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/s11017-011-9189-6 [doi]
PST - ppublish
SO  - Theor Med Bioeth. 2011 Oct;32(5):337-50. doi: 10.1007/s11017-011-9189-6.


PMID- 21858208
OWN - NLM
STAT- MEDLINE
DCOM- 20120215
LR  - 20211020
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 6
IP  - 8
DP  - 2011
TI  - Newly developed Mg2+-selective fluorescent probe enables visualization of Mg2+
      dynamics in mitochondria.
PG  - e23684
LID - 10.1371/journal.pone.0023684 [doi]
AB  - Mg(2+) plays important roles in numerous cellular functions. Mitochondria take
      part in intracellular Mg(2+) regulation and the Mg(2+) concentration in
      mitochondria affects the synthesis of ATP. However, there are few methods to
      observe Mg(2+) in mitochondria in intact cells. Here, we have developed a novel
      Mg(2+)-selective fluorescent probe, KMG-301, that is functional in mitochondria. 
      This probe changes its fluorescence properties solely depending on the Mg(2+)
      concentration in mitochondria under physiologically normal conditions.
      Simultaneous measurements using this probe together with a probe for cytosolic
      Mg(2+), KMG-104, enabled us to compare the dynamics of Mg(2+) in the cytosol and 
      in mitochondria. With this method, carbonyl cyanide p-(trifluoromethoxy)
      phenylhydrazone (FCCP)-induced Mg(2+) mobilization from mitochondria to the
      cytosol was visualized. Although a FCCP-induced decrease in the Mg(2+)
      concentration in mitochondria and an increase in the cytosol were observed both
      in differentiated PC12 cells and in hippocampal neurons, the time-courses of
      concentration changes varied with cell type. Moreover, the relationship between
      mitochondrial Mg(2+) and Parkinson's disease was analyzed in a cellular model of 
      Parkinson's disease by using the 1-methyl-4-phenylpyridinium ion (MPP(+)). A
      gradual decrease in the Mg(2+) concentration in mitochondria was observed in
      response to MPP(+) in differentiated PC12 cells. These results indicate that
      KMG-301 is useful for investigating Mg(2+) dynamics in mitochondria. All animal
      procedures to obtain neurons from Wistar rats were approved by the ethical
      committee of Keio University (permit number is 09106-(1)).
FAU - Shindo, Yutaka
AU  - Shindo Y
AD  - Center for Biosciences and Informatics, Graduate School of Science and
      Technology, Keio University, Yokohama, Kanagawa, Japan.
FAU - Fujii, Tomohiko
AU  - Fujii T
FAU - Komatsu, Hirokazu
AU  - Komatsu H
FAU - Citterio, Daniel
AU  - Citterio D
FAU - Hotta, Kohji
AU  - Hotta K
FAU - Suzuki, Koji
AU  - Suzuki K
FAU - Oka, Kotaro
AU  - Oka K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110816
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Cation Transport Proteins)
RN  - 0 (Fluorescent Dyes)
RN  - 0 (MRS2 protein, rat)
RN  - 0 (Mitochondrial Proteins)
RN  - 0 (Proton Ionophores)
RN  - 0 (RNA, Small Interfering)
RN  - 147336-22-9 (Green Fluorescent Proteins)
RN  - 370-86-5 (Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone)
RN  - I38ZP9992A (Magnesium)
RN  - R865A5OY8J (1-Methyl-4-phenylpyridinium)
SB  - IM
MH  - 1-Methyl-4-phenylpyridinium/pharmacology
MH  - Animals
MH  - Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone/pharmacology
MH  - Cation Transport Proteins/genetics/metabolism
MH  - Cells, Cultured
MH  - Cytosol/chemistry/metabolism
MH  - Fluorescent Dyes/chemical synthesis/*chemistry
MH  - Green Fluorescent Proteins/genetics/metabolism
MH  - Hippocampus/cytology
MH  - Ion Transport/drug effects
MH  - Magnesium/chemistry/*metabolism
MH  - Microscopy, Confocal
MH  - Mitochondria/chemistry/drug effects/*metabolism
MH  - Mitochondrial Proteins/genetics/metabolism
MH  - *Molecular Dynamics Simulation
MH  - Molecular Structure
MH  - Neurons/chemistry/drug effects/metabolism
MH  - PC12 Cells
MH  - Proton Ionophores/pharmacology
MH  - RNA, Small Interfering/genetics
MH  - Rats
MH  - Rats, Wistar
MH  - Spectrometry, Fluorescence
MH  - Transfection
PMC - PMC3156752
EDAT- 2011/08/23 06:00
MHDA- 2012/02/16 06:00
CRDT- 2011/08/23 06:00
PHST- 2011/04/07 00:00 [received]
PHST- 2011/07/22 00:00 [accepted]
PHST- 2011/08/23 06:00 [entrez]
PHST- 2011/08/23 06:00 [pubmed]
PHST- 2012/02/16 06:00 [medline]
AID - 10.1371/journal.pone.0023684 [doi]
AID - PONE-D-11-06469 [pii]
PST - ppublish
SO  - PLoS One. 2011;6(8):e23684. doi: 10.1371/journal.pone.0023684. Epub 2011 Aug 16.


PMID- 21857855
OWN - NLM
STAT- MEDLINE
DCOM- 20111028
LR  - 20211020
IS  - 1729-0503 (Electronic)
IS  - 1680-6905 (Linking)
VI  - 11
IP  - 2
DP  - 2011 Jun
TI  - Reference values for serum levels of folic acid and vitamin B12 in a young adult 
      Ugandan population.
PG  - 240-3
AB  - INTRODUCTION: Reference values may vary significantly among populations and
      cultures for which dietary intakes may be different. Each laboratory is expected 
      to investigate the transferability of the expected values to its own patient
      population and if necessary determine its own reference ranges. This study sought
      to establish Folic acid and Vitamin B(12) reference values for young Ugandan
      adults, which reference values could be used as baseline information for future
      research, especially related to their role in breast cancer prevention. METHODS: 
      A cross sectional study in which 200 undergraduate student volunteers were
      enrolled. The minimum sample size was 126 using the Open Epi version 2. Relevant 
      demographics and physical examination parameters were taken as well as blood
      samples for laboratory tests. Prior ethical approval was granted. RESULTS: The
      levels of folic acid were 4.17 - 20 ng/ml and remained constant over the age
      cohorts. The vitamin B(12) range was 117-1158 pg/ml. Both ranges were comparable 
      to ranges seen in other populations. CONCLUSION: In as much as the dietary intake
      for this study population is presumed different from populations in the western
      countries, the ranges for these two vitamins were similar.
FAU - Galukande, M
AU  - Galukande M
AD  - Department of Surgery, School of Medicine, College of Health Sciences, Makerere
      University, Ugandan. mosesg@img.co.ug
FAU - Jombwe, J
AU  - Jombwe J
FAU - Fualal, J
AU  - Fualal J
FAU - Baingana, R
AU  - Baingana R
FAU - Gakwaya, A
AU  - Gakwaya A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Uganda
TA  - Afr Health Sci
JT  - African health sciences
JID - 101149451
RN  - 0 (Hemoglobins)
RN  - 12001-76-2 (Vitamin B Complex)
RN  - 935E97BOY8 (Folic Acid)
RN  - P6YC3EG204 (Vitamin B 12)
SB  - IM
MH  - Adult
MH  - Body Mass Index
MH  - Cross-Sectional Studies
MH  - Female
MH  - Folic Acid/*blood
MH  - Hemoglobins/analysis
MH  - Humans
MH  - Male
MH  - Reference Values
MH  - Students
MH  - Uganda
MH  - Vitamin B 12/*blood
MH  - Vitamin B Complex/*blood
MH  - Young Adult
PMC - PMC3158514
OTO - NOTNLM
OT  - Folic acid
OT  - Reference Serum levels
OT  - Vitamin B12
EDAT- 2011/08/23 06:00
MHDA- 2011/10/29 06:00
CRDT- 2011/08/23 06:00
PHST- 2011/08/23 06:00 [entrez]
PHST- 2011/08/23 06:00 [pubmed]
PHST- 2011/10/29 06:00 [medline]
PST - ppublish
SO  - Afr Health Sci. 2011 Jun;11(2):240-3.


PMID- 21857542
OWN - NLM
STAT- MEDLINE
DCOM- 20111122
LR  - 20110912
IS  - 1534-6080 (Electronic)
IS  - 0041-1337 (Linking)
VI  - 92
IP  - 6
DP  - 2011 Sep 27
TI  - Voluntariness in living-related organ donation.
PG  - 617-9
LID - 10.1097/TP.0b013e3182279120 [doi]
AB  - Living organ donation requires hurting one person-at least physically-to help
      another. This can be morally justifiable if certain ethical criteria are met,
      among them voluntary and informed consent. In the existing guidance,
      voluntariness is usually vaguely defined as the absence of coercion. This,
      however, is not enough as a basis for making well-considered decisions in
      individual cases. A comprehensive evaluation, procedural safeguards, and critical
      awareness of potential pitfalls can help establish the voluntariness of the
      donor's decision.
FAU - Biller-Andorno, Nikola
AU  - Biller-Andorno N
AD  - Institute of Biomedical Ethics, University of Zurich, Switzerland.
      biller-andorno@ethik.uzh.ch
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
SB  - IM
MH  - Altruism
MH  - Bioethics
MH  - Decision Making
MH  - Humans
MH  - Informed Consent
MH  - Living Donors
MH  - Personal Autonomy
MH  - Tissue Donors
MH  - Tissue and Organ Procurement/*ethics/*methods
MH  - Transplantation/*ethics/*methods
EDAT- 2011/08/23 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/08/23 06:00
PHST- 2011/08/23 06:00 [entrez]
PHST- 2011/08/23 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1097/TP.0b013e3182279120 [doi]
PST - ppublish
SO  - Transplantation. 2011 Sep 27;92(6):617-9. doi: 10.1097/TP.0b013e3182279120.


PMID- 21857276
OWN - NLM
STAT- MEDLINE
DCOM- 20120618
LR  - 20190109
IS  - 1532-8651 (Electronic)
IS  - 1098-7339 (Linking)
VI  - 36
IP  - 5
DP  - 2011 Sep-Oct
TI  - Does continuous sciatic nerve block improve postoperative analgesia and early
      rehabilitation after total knee arthroplasty? A prospective, randomized,
      double-blinded study.
PG  - 489-92
LID - 10.1097/AAP.0b013e3182286a2b [doi]
AB  - INTRODUCTION: The aim of this prospective, randomized, double-blind study was to 
      evaluate whether continuous sciatic nerve block can improve postoperative pain
      relief and early rehabilitation compared with single-injection sciatic nerve
      block in patients undergoing total knee arthroplasty (TKA) and lumbar plexus
      block. METHODS: After ethical committee approval and written informed consent, 38
      patients with ASA physical status I to II were enrolled. The first group received
      continuous sciatic and continuous lumbar plexus blocks (group regional or R, n = 
      19), whereas the second group received a single sciatic nerve block followed by
      saline infusion through the sciatic catheter and continuous lumbar plexus block
      (group control or C, n = 19). We assessed morphine consumption, scores for visual
      analog scale for pain at rest (VASr), and during continuous passive motion (VASi 
      during CPM) for 48 hours postoperatively. Effectiveness of early ambulation was
      also evaluated. RESULTS: Scores for VASr and VASi during CPM, as well as morphine
      consumption, were significantly higher in group C than in group R (P < 0.01).
      Moreover, patients in group R showed earlier rehabilitation with more effective
      ambulation (P < 0.05). CONCLUSIONS: Continuous sciatic nerve block improves
      analgesia, decreases morphine request, and improves early rehabilitation compared
      with single-injection sciatic nerve block in patients undergoing TKA and lumbar
      plexus block.
FAU - Cappelleri, Gianluca
AU  - Cappelleri G
AD  - Azienda Ospedaliera Istituto Ortopedico Gaetano Pini, Milan, Italy.
      kappe@hotmail.com
FAU - Ghisi, Daniela
AU  - Ghisi D
FAU - Fanelli, Andrea
AU  - Fanelli A
FAU - Albertin, Andrea
AU  - Albertin A
FAU - Somalvico, Francesco
AU  - Somalvico F
FAU - Aldegheri, Giorgio
AU  - Aldegheri G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - Reg Anesth Pain Med
JT  - Regional anesthesia and pain medicine
JID - 9804508
RN  - 0 (Anesthetics, Local)
SB  - IM
CIN - Reg Anesth Pain Med. 2012 Jan-Feb;37(1):122-3; author reply 123-4. PMID: 22189583
MH  - Aged
MH  - Analgesia/*methods
MH  - Anesthetics, Local/*administration & dosage
MH  - Arthroplasty, Replacement, Knee/adverse effects/*methods
MH  - Double-Blind Method
MH  - Early Ambulation/*methods
MH  - Female
MH  - Humans
MH  - Infusions, Intravenous
MH  - Male
MH  - Middle Aged
MH  - Nerve Block/*methods
MH  - Pain Measurement/drug effects/methods
MH  - Pain, Postoperative/etiology/*prevention & control
MH  - Prospective Studies
MH  - *Sciatic Nerve/drug effects/physiology
EDAT- 2011/08/23 06:00
MHDA- 2012/06/19 06:00
CRDT- 2011/08/23 06:00
PHST- 2011/08/23 06:00 [entrez]
PHST- 2011/08/23 06:00 [pubmed]
PHST- 2012/06/19 06:00 [medline]
AID - 10.1097/AAP.0b013e3182286a2b [doi]
PST - ppublish
SO  - Reg Anesth Pain Med. 2011 Sep-Oct;36(5):489-92. doi:
      10.1097/AAP.0b013e3182286a2b.


PMID- 21857242
OWN - NLM
STAT- MEDLINE
DCOM- 20111222
LR  - 20110822
IS  - 1549-8425 (Electronic)
IS  - 1549-8417 (Linking)
VI  - 7
IP  - 3
DP  - 2011 Sep
TI  - Physicians-in-training attitudes on patient safety: 2003 to 2008.
PG  - 133-8
LID - 10.1097/PTS.0b013e31822a9c5e [doi]
AB  - OBJECTIVE: : Physician trainees will embody medicine's future culture. We assess 
      whether trainees' patient safety attitudes have evolved over time. METHODS: : We 
      anonymously surveyed more than 800 house staff and fourth-year medical students
      (MS 4) in 2008, at 1 academic institution, with a 19-item questionnaire and
      compared their responses to the 2003 responses at the same institution on the
      same questionnaire. RESULTS: : A total of 463 trainees (53%) completed the 2008
      survey, with a mean overall safety score of 3.54, which significantly improved
      from the 2003 overall score of 3.41 (P < 0.001). Compared with those from 2003,
      respondents in 2008 more strongly agree that physician-nurse teamwork (P =
      0.001), attending supervision (P = 0.017), 80-hour workweek (P < 0.001), computer
      order entry (P < 0.001), and improved resident sign-out (P < 0.001) help reduce
      adverse events. The 2008 trainees feel more prepared to prevent adverse events (P
      = 0.030) and more acknowledge the ethical responsibility to disclose adverse
      events to patients (P = 0.002). However, compared with 2003, fewer 2008
      respondents felt that reducing nurses' patient load would reduce adverse events
      (P = 0.015); on 8 questionnaire items, there were no significant attitudinal
      changes between 2003 and 2008. CONCLUSIONS: : Physician trainee safety attitudes 
      at 1 institution improved between 2003 and 2008, and these trainees support many 
      system-based solutions to adverse events. The changes seem incremental and
      responses do not fully align with all aspects of a safety culture. Cultural
      change in health care must involve trainees and address their attitudes.
FAU - Sorokin, Rachel
AU  - Sorokin R
AD  - Thomas Jefferson University Hospital, Divisions of Internal Medicine
      Philadelphia, Pennsylvania, USA. rachel.sorokin@jefferson.edu
FAU - Riggio, Jeffrey M
AU  - Riggio JM
FAU - Moleski, Stephanie
AU  - Moleski S
FAU - Sullivan, Jacqueline
AU  - Sullivan J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Patient Saf
JT  - Journal of patient safety
JID - 101233393
SB  - IM
MH  - Academic Medical Centers/organization & administration
MH  - *Attitude of Health Personnel
MH  - Continuity of Patient Care/organization & administration
MH  - Electronic Prescribing
MH  - Hospital Bed Capacity, 500 and over
MH  - Humans
MH  - *Internship and Residency
MH  - Organizational Culture
MH  - Patient Care Team/organization & administration
MH  - *Patient Safety
MH  - Time Factors
EDAT- 2011/08/23 06:00
MHDA- 2011/12/23 06:00
CRDT- 2011/08/23 06:00
PHST- 2011/08/23 06:00 [entrez]
PHST- 2011/08/23 06:00 [pubmed]
PHST- 2011/12/23 06:00 [medline]
AID - 10.1097/PTS.0b013e31822a9c5e [doi]
PST - ppublish
SO  - J Patient Saf. 2011 Sep;7(3):133-8. doi: 10.1097/PTS.0b013e31822a9c5e.


PMID- 21857239
OWN - NLM
STAT- MEDLINE
DCOM- 20111222
LR  - 20110822
IS  - 1549-8425 (Electronic)
IS  - 1549-8417 (Linking)
VI  - 7
IP  - 3
DP  - 2011 Sep
TI  - Physicians' attitudes toward reporting medical errors-an observational study at a
      general hospital in Saudi Arabia.
PG  - 144-7
LID - 10.1097/PTS.0b013e31822c5a82 [doi]
AB  - OBJECTIVE: : Accurate medical error reporting is crucial for reducing the
      occurrence of such errors and their adverse consequences. This study aims to
      investigate the views of physicians about medical error reporting in a tertiary
      care hospital in Saudi Arabia. METHODS: : This is a cross-sectional
      self-administrated survey study. All physicians in the hospital were invited to
      complete an anonymous survey questionnaire addressing demographic details, as
      well as attitudes, practice, and views on medical error reporting. RESULTS: : One
      hundred seven physicians completed the questionnaires (66.5% response rate). Mean
      (SD) age was 39.8 (9.0) years. One-fifth of the respondents worked in the
      emergency department, and half had a workload of 40 to 59 h/wk. The reason given 
      by 41.1% for not reporting a medical error by a colleague was that "it is not
      their responsibility." However, the gravity of the outcome of a medical error by 
      a colleague to the patient was thought to be an important incentive for
      reporting. Of the physicians, 43% agreed that they would conceal the occurrence
      of a medical error they incurred to "avoid punishment." Nevertheless, most of the
      respondents held the view that there exists an ethical underpinning for reporting
      medical errors and that reporting of medical errors serve a valuable purpose.
      CONCLUSIONS: : The physicians in our study are likely to disclose errors made by 
      a colleague only if the error resulted in a severe damage to the patient, and as 
      such, medical errors go underreported for a variety of reasons. It was felt that 
      assurance of confidentiality and protection from backlash would promote medical
      error disclosure.
FAU - Alsafi, Eiman
AU  - Alsafi E
AD  - Quality Management Department, King Saud Chest Specialty Hospital, Saudi Arabia.
FAU - Bahroon, Salim A
AU  - Bahroon SA
FAU - Tamim, Hani
AU  - Tamim H
FAU - Al-Jahdali, Hamdan H
AU  - Al-Jahdali HH
FAU - Alzahrani, Saeed
AU  - Alzahrani S
FAU - Al Sayyari, Abdullah
AU  - Al Sayyari A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Patient Saf
JT  - Journal of patient safety
JID - 101233393
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Cross-Sectional Studies
MH  - *Disclosure
MH  - Female
MH  - Hospitals, General
MH  - Humans
MH  - Male
MH  - *Medical Errors
MH  - Middle Aged
MH  - Physicians/*psychology
MH  - *Risk Management
MH  - Saudi Arabia
MH  - Socioeconomic Factors
EDAT- 2011/08/23 06:00
MHDA- 2011/12/23 06:00
CRDT- 2011/08/23 06:00
PHST- 2011/08/23 06:00 [entrez]
PHST- 2011/08/23 06:00 [pubmed]
PHST- 2011/12/23 06:00 [medline]
AID - 10.1097/PTS.0b013e31822c5a82 [doi]
PST - ppublish
SO  - J Patient Saf. 2011 Sep;7(3):144-7. doi: 10.1097/PTS.0b013e31822c5a82.


PMID- 21857123
OWN - NLM
STAT- MEDLINE
DCOM- 20111220
LR  - 20131121
IS  - 1529-8795 (Electronic)
IS  - 0031-5982 (Linking)
VI  - 54
IP  - 3
DP  - 2011 Summer
TI  - Compassionate use: a story of ethics and science in the development of a new
      drug.
PG  - 304-15
LID - 10.1353/pbm.2011.0027 [doi]
AB  - This history chronicles the unusual development of the antiviral drug
      ganciclovir. The first compound with activity against human cytomegalovirus
      (CMV), ganciclovir was so clearly efficacious that a placebo-controlled clinical 
      trial could not ethically be done, and the FDA rejected the first application to 
      market the drug. Used to treat a blinding eye infection in patients with AIDS,
      the story of ganciclovir paralleled the spread of the AIDS epidemic. Both
      ganciclovir and AIDS caught the federal government off guard. Caught in a
      Catch-22 situation, the pharmaceutical company developing ganciclovir gave the
      drug away free for five years under compassionate use guidelines. The problems
      encountered in the development of ganciclovir provide guidance on how future
      drugs to treat life-threatening diseases can be developed.
FAU - Buhles, William C
AU  - Buhles WC
AD  - Clinical Science Consulting, 612 Oak Avenue, Davis, CA 95616, USA.
      wbuhles@msn.com
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - Perspect Biol Med
JT  - Perspectives in biology and medicine
JID - 0401132
RN  - 0 (Antiviral Agents)
RN  - P9G3CKZ4P5 (Ganciclovir)
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/complications/epidemiology/virology
MH  - Antiviral Agents/history/therapeutic use
MH  - Compassionate Use Trials/*ethics
MH  - Cytomegalovirus/drug effects/pathogenicity
MH  - Cytomegalovirus Infections/complications/*drug therapy/virology
MH  - Drug Approval/*legislation & jurisprudence
MH  - Drug Dosage Calculations
MH  - Drug Industry
MH  - Ganciclovir/*history/*therapeutic use
MH  - HIV/pathogenicity
MH  - History, 20th Century
MH  - Humans
MH  - Retinitis/complications/drug therapy/virology
MH  - United States
EDAT- 2011/08/23 06:00
MHDA- 2011/12/21 06:00
CRDT- 2011/08/23 06:00
PHST- 2011/08/23 06:00 [entrez]
PHST- 2011/08/23 06:00 [pubmed]
PHST- 2011/12/21 06:00 [medline]
AID - S1529879511300075 [pii]
AID - 10.1353/pbm.2011.0027 [doi]
PST - ppublish
SO  - Perspect Biol Med. 2011 Summer;54(3):304-15. doi: 10.1353/pbm.2011.0027.


PMID- 21856238
OWN - NLM
STAT- MEDLINE
DCOM- 20120210
LR  - 20111003
IS  - 1525-5069 (Electronic)
IS  - 1525-5050 (Linking)
VI  - 22
IP  - 2
DP  - 2011 Oct
TI  - Ethical issues in surgical decision making concerning children with medically
      intractable epilepsy.
PG  - 154-7
LID - 10.1016/j.yebeh.2011.07.008 [doi]
AB  - The widespread inclusion of surgical strategies in the treatment of medically
      intractable epilepsy is largely justified by the medical and psychosocial burden 
      of the illness. Performing these procedures in pediatric populations is
      associated with distinct challenges ranging from unique seizure etiologies to
      issues surrounding brain development and functional plasticity. As the trend
      toward more aggressive surgical intervention continues, the ethical foundation of
      current and emerging practices must be increasingly scrutinized. Here, we present
      the first article discussing ethical issues in the surgical management of
      medically intractable epilepsies in children. We discuss principles of informed
      consent, harm reduction, and justice in this vulnerable patient population. We
      also highlight the unique ethical challenge of surgical decision making
      concerning developmentally delayed children. The recognition of these issues is
      essential to providing patient-centered, responsible, and ethical care.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Ibrahim, George M
AU  - Ibrahim GM
AD  - Division of Neurosurgery, Hospital for Sick Children and Toronto Western
      Hospital, Toronto, ON, Canada. george.m.ibrahim@gmail.com
FAU - Fallah, Aria
AU  - Fallah A
FAU - Snead, O Carter 3rd
AU  - Snead OC 3rd
FAU - Elliott, Irene
AU  - Elliott I
FAU - Drake, James M
AU  - Drake JM
FAU - Bernstein, Mark
AU  - Bernstein M
FAU - Rutka, James T
AU  - Rutka JT
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Epilepsy Behav
JT  - Epilepsy & behavior : E&B
JID - 100892858
SB  - IM
MH  - Adolescent
MH  - Child, Preschool
MH  - *Decision Making
MH  - Epilepsy/*surgery
MH  - *Ethics
MH  - Humans
MH  - Informed Consent/ethics
MH  - Male
MH  - Neurosurgery/ethics/methods
MH  - Pediatrics/*ethics
EDAT- 2011/08/23 06:00
MHDA- 2012/02/11 06:00
CRDT- 2011/08/23 06:00
PHST- 2011/06/20 00:00 [received]
PHST- 2011/07/06 00:00 [revised]
PHST- 2011/07/15 00:00 [accepted]
PHST- 2011/08/23 06:00 [entrez]
PHST- 2011/08/23 06:00 [pubmed]
PHST- 2012/02/11 06:00 [medline]
AID - S1525-5050(11)00417-3 [pii]
AID - 10.1016/j.yebeh.2011.07.008 [doi]
PST - ppublish
SO  - Epilepsy Behav. 2011 Oct;22(2):154-7. doi: 10.1016/j.yebeh.2011.07.008.


PMID- 21855932
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20141120
IS  - 1527-3792 (Electronic)
IS  - 0022-5347 (Linking)
VI  - 186
IP  - 4 Suppl
DP  - 2011 Oct
TI  - Physiological changes in transperitoneal versus retroperitoneal laparoscopy in
      children: a prospective analysis.
PG  - 1649-52
LID - 10.1016/j.juro.2011.03.069 [doi]
AB  - PURPOSE: The choice of minimally invasive surgical approaches in pediatric
      urology is largely influenced by surgeon preference and experience. Little is
      known about the differences in physiological variables that might objectively
      influence the choice of surgical approach. We compared the cerebral and systemic 
      hemodynamic effects of transperitoneal vs retroperitoneal CO(2) insufflation in
      children. MATERIALS AND METHODS: After receiving ethical review board approval
      and written parental consent 36 pediatric patients undergoing transperitoneal
      (18) or retroperitoneal (18) laparoscopic surgery were enrolled in this study. A 
      standardized anesthetic technique of isoflurane 1 MAC and remifentanil 0.2 mcg/kg
      per minute was used. Measured parameters included end tidal CO(2), middle
      cerebral artery blood flow velocity, heart rate and noninvasive mean arterial
      blood pressure. Transcranial Doppler ultrasound was used to measure middle
      cerebral artery blood flow velocity. Data were collected before, during and after
      CO(2) insufflation to 12 mm Hg pneumoperitoneum at regular intervals, including
      every minute for 10 minutes and every 2 minutes thereafter. Within group analysis
      was done using repeated measures ANOVA. Nonlinear regression analysis was used to
      determine the best fit and the relationship of each variable with time with p
      <0.05 considered significant. RESULTS: Patient age and weight were comparable in 
      the 2 groups. Transperitoneal CO(2) insufflation resulted in a rapid parallel
      increase in middle cerebral artery blood flow velocity, mean arterial pressure
      and end tidal CO(2) during the first 8 minutes of pneumoperitoneum (p <0.05).
      Despite a continued increase in end tidal CO(2) thereafter middle cerebral artery
      blood flow velocity and mean arterial pressure attained a plateau within the
      first 8 minutes (p <0.05). In contrast, middle cerebral artery blood flow
      velocity and end tidal CO(2) increased progressively throughout the
      retroperitoneal CO(2) insufflation period (p <0.01). CONCLUSIONS: Cerebral blood 
      flow velocity and end tidal CO(2) seem to increase progressively and gradually
      during retroperitoneal laparoscopy, in contrast to the more rapid increase and
      plateau effect during transperitoneal laparoscopy. Presumably the smaller
      absorptive surface in the retroperitoneal space explains this physiological
      difference.
CI  - Copyright (c) 2011 American Urological Association Education and Research, Inc.
      Published by Elsevier Inc. All rights reserved.
FAU - Karsli, Cengiz
AU  - Karsli C
AD  - Department of Anesthesiology, Hospital for Sick Children, Toronto, Ontario,
      Canada.
FAU - El-Hout, Yaser
AU  - El-Hout Y
FAU - Lorenzo, Armando J
AU  - Lorenzo AJ
FAU - Langer, Jacob C
AU  - Langer JC
FAU - Bagli, Darius J
AU  - Bagli DJ
FAU - Pippi Salle, Joao L
AU  - Pippi Salle JL
FAU - Bissonette, Bruno
AU  - Bissonette B
FAU - Farhat, Walid A
AU  - Farhat WA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110819
PL  - United States
TA  - J Urol
JT  - The Journal of urology
JID - 0376374
RN  - 142M471B3J (Carbon Dioxide)
SB  - IM
MH  - Adolescent
MH  - Blood Flow Velocity
MH  - Blood Pressure/*physiology
MH  - Carbon Dioxide/administration & dosage/pharmacokinetics
MH  - Cerebrovascular Circulation/*physiology
MH  - Child
MH  - Child, Preschool
MH  - Elective Surgical Procedures/methods
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Rate/*physiology
MH  - Humans
MH  - Infant
MH  - Intraoperative Period
MH  - Laparoscopy/*methods
MH  - Male
MH  - Middle Cerebral Artery/physiology
MH  - *Pneumoperitoneum, Artificial
MH  - Prognosis
MH  - Prospective Studies
MH  - Retroperitoneal Space/*surgery
MH  - Ultrasonography, Doppler, Transcranial
MH  - Urologic Diseases/metabolism/*surgery
EDAT- 2011/08/23 06:00
MHDA- 2011/11/09 06:00
CRDT- 2011/08/23 06:00
PHST- 2010/11/27 00:00 [received]
PHST- 2011/08/23 06:00 [entrez]
PHST- 2011/08/23 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - S0022-5347(11)03381-7 [pii]
AID - 10.1016/j.juro.2011.03.069 [doi]
PST - ppublish
SO  - J Urol. 2011 Oct;186(4 Suppl):1649-52. doi: 10.1016/j.juro.2011.03.069. Epub 2011
      Aug 19.


PMID- 21855918
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20110912
IS  - 1527-3792 (Electronic)
IS  - 0022-5347 (Linking)
VI  - 186
IP  - 4 Suppl
DP  - 2011 Oct
TI  - Cremaster muscle myogenesis in the tip of the rat gubernaculum supports active
      gubernacular elongation during inguinoscrotal testicular descent.
PG  - 1606-13
LID - 10.1016/j.juro.2011.04.012 [doi]
AB  - PURPOSE: Cryptorchidism is a common abnormality and normal testicular descent is 
      controlled by the gubernaculum. The cremaster may originate from abdominal
      muscles during gubernacular eversion or alternatively it may develop inside the
      gubernaculum. We studied cremaster myogenesis to determine how it develops.
      MATERIALS AND METHODS: Coronal sections of the pelvis were prepared from male
      Sprague-Dawley(R) rats and from males treated prenatally with the antiandrogen
      flutamide at embryonic day 19, and postnatal days 10, 19 and 35 after receiving
      ethical approval. Immunohistochemical stains were prepared for Ki67, Pax-7,
      myogenin, myosin heavy chain 7, Myh1, Myh2, Myh4, embryonic myosin, and slow and 
      cardiac troponin T. Cell counts of the 1) gubernacular tip, 2) proximal
      gubernaculum/cremaster muscle and 3) adjacent abdominal wall are shown as a
      percent of positive fibers or positive cells per area. RESULTS: Throughout
      embryonic day 19, and postnatal days 10 and 19 proliferation (Ki67) was maximal
      at the gubernacular tip (p <0.001), as were muscle stem cells markers (Pax-7 p
      <0.05), early myogenesis (myogenin p <0.001) and immature muscle (Myh7, and slow 
      and cardiac troponin T p <0.0001). In contrast, secondary (fast twitch, Myh1, 2
      and 4) fibers were more common in abdominal muscles (p <0.0001). Differences in
      muscle maturity and composition decreased with time. Flutamide treated rats
      showed more cellular proliferation than controls postnatally on postnatal day 10 
      (p <0.001) as well as persistent immature embryonic myosin at the tip from
      postnatal day 19 (p <0.05). CONCLUSIONS: Results show that the rat cremaster
      muscle is more immature at the gubernacular tip, consistent with myogenesis
      occurring in the gubernaculum during migration to the scrotum, as proposed in
      humans.
CI  - Copyright (c) 2011 American Urological Association Education and Research, Inc.
      Published by Elsevier Inc. All rights reserved.
FAU - Sanders, Nicholas
AU  - Sanders N
AD  - F Douglas Stephens Surgical Research Laboratory, Murdoch Childrens Research
      Institute, Department of Paediatrics, University of Melbourne, Melbourne,
      Victoria, Australia.
FAU - Buraundi, Silverton
AU  - Buraundi S
FAU - Balic, Adam
AU  - Balic A
FAU - Southwell, Bridget R
AU  - Southwell BR
FAU - Hutson, John M
AU  - Hutson JM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110819
PL  - United States
TA  - J Urol
JT  - The Journal of urology
JID - 0376374
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Cryptorchidism/*embryology
MH  - Disease Models, Animal
MH  - Inguinal Canal/*embryology
MH  - Male
MH  - *Muscle Development
MH  - Muscle, Smooth/*embryology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Scrotum/*embryology
MH  - Testis/*embryology
EDAT- 2011/08/23 06:00
MHDA- 2011/11/09 06:00
CRDT- 2011/08/23 06:00
PHST- 2010/11/30 00:00 [received]
PHST- 2011/08/23 06:00 [entrez]
PHST- 2011/08/23 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - S0022-5347(11)03615-9 [pii]
AID - 10.1016/j.juro.2011.04.012 [doi]
PST - ppublish
SO  - J Urol. 2011 Oct;186(4 Suppl):1606-13. doi: 10.1016/j.juro.2011.04.012. Epub 2011
      Aug 19.


PMID- 21855712
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111102
LR  - 20110822
IS  - 1557-8240 (Electronic)
IS  - 0031-3955 (Linking)
VI  - 58
IP  - 4
DP  - 2011 Aug
TI  - Psychiatric issues in pediatric organ transplantation.
PG  - 887-901, x
LID - 10.1016/j.pcl.2011.06.011 [doi]
AB  - Solid organ transplantation has become the first line of treatment for a growing 
      number of life-threatening pediatric illnesses. With improved survival, research 
      into the long-term outcome of transplant recipients has become important to
      clinicians. Adherence to medical instructions remains a challenge, particularly
      in the adolescent population. New immunosuppressant approaches promise to expand 
      organ transplantation in additional directions. Extension of transplantation into
      replacement of organs such as faces and hands raises complex ethical issues.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Stuber, Margaret L
AU  - Stuber ML
AD  - Department of Psychiatry and Biobehavioral Sciences, Semel Institute, David
      Geffen School of Medicine at UCLA, 760 Westwood Plaza, Room 48-240, Los Angeles, 
      CA 90024-1759, USA. mstuber@mednet.ucla.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Pediatr Clin North Am
JT  - Pediatric clinics of North America
JID - 0401126
RPF - Child Adolesc Psychiatr Clin N Am. 2010 Apr;19(2):285-300, viii-ix. PMID:
      20478500
EDAT- 2011/08/23 06:00
MHDA- 2011/08/23 06:01
CRDT- 2011/08/23 06:00
PHST- 2011/08/23 06:00 [entrez]
PHST- 2011/08/23 06:00 [pubmed]
PHST- 2011/08/23 06:01 [medline]
AID - S0031-3955(11)00070-8 [pii]
AID - 10.1016/j.pcl.2011.06.011 [doi]
PST - ppublish
SO  - Pediatr Clin North Am. 2011 Aug;58(4):887-901, x. doi: 10.1016/j.pcl.2011.06.011.


PMID- 21855170
OWN - NLM
STAT- MEDLINE
DCOM- 20120413
LR  - 20220321
IS  - 1097-6760 (Electronic)
IS  - 0196-0644 (Linking)
VI  - 59
IP  - 3
DP  - 2012 Mar
TI  - Allocating scarce resources in disasters: emergency department principles.
PG  - 177-87
LID - 10.1016/j.annemergmed.2011.06.012 [doi]
AB  - Decisions about medical resource triage during disasters require a planned
      structured approach, with foundational elements of goals, ethical principles,
      concepts of operations for reactive and proactive triage, and decision tools
      understood by the physicians and staff before an incident. Though emergency
      physicians are often on the front lines of disaster situations, too often they
      have not considered how they should modify their decisionmaking or use of
      resources to allow the "greatest good for the greatest number" to be
      accomplished. This article reviews key concepts from the disaster literature,
      providing the emergency physician with a framework of ethical and operational
      principles on which medical interventions provided may be adjusted according to
      demand and the resources available. Incidents may require a range of responses
      from an institution and providers, from conventional (maximal use of usual space,
      staff, and supplies) to contingency (use of other patient care areas and
      resources to provide functionally equivalent care) and crisis (adjusting care
      provided to the resources available when usual care cannot be provided). This
      continuum is defined and may be helpful when determining the scope of response
      and assistance necessary in an incident. A range of strategies is reviewed that
      can be implemented when there is a resource shortfall. The resource and staff
      requirements of specific incident types (trauma, burn incidents) are briefly
      considered, providing additional preparedness and decisionmaking tactics to the
      emergency provider. It is difficult to think about delivering medical care under 
      austere conditions. Preparation and understanding of the decisions required and
      the objectives, strategies, and tactics available can result in better-informed
      decisions during an event. In turn, adherence to such a response framework can
      yield thoughtful stewardship of resources and improved outcomes for a larger
      number of patients.
CI  - Copyright (c) 2011 American College of Emergency Physicians. Published by Mosby, 
      Inc. All rights reserved.
FAU - Hick, John L
AU  - Hick JL
AD  - Hennepin County Medical Center, University of Minnesota, Minneapolis, MN, USA.
      john.hick@hcmed.org
FAU - Hanfling, Dan
AU  - Hanfling D
FAU - Cantrill, Stephen V
AU  - Cantrill SV
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110819
PL  - United States
TA  - Ann Emerg Med
JT  - Annals of emergency medicine
JID - 8002646
SB  - IM
MH  - Disaster Medicine/ethics/methods
MH  - *Disasters
MH  - Emergency Medicine/ethics/organization & administration/standards
MH  - *Emergency Service, Hospital/ethics/organization & administration/standards
MH  - Humans
MH  - *Resource Allocation/ethics/organization & administration/standards
MH  - Surge Capacity
MH  - Triage/ethics/organization & administration/standards
EDAT- 2011/08/23 06:00
MHDA- 2012/04/14 06:00
CRDT- 2011/08/23 06:00
PHST- 2011/02/28 00:00 [received]
PHST- 2011/05/18 00:00 [revised]
PHST- 2011/06/16 00:00 [accepted]
PHST- 2011/08/23 06:00 [entrez]
PHST- 2011/08/23 06:00 [pubmed]
PHST- 2012/04/14 06:00 [medline]
AID - S0196-0644(11)00676-7 [pii]
AID - 10.1016/j.annemergmed.2011.06.012 [doi]
PST - ppublish
SO  - Ann Emerg Med. 2012 Mar;59(3):177-87. doi: 10.1016/j.annemergmed.2011.06.012.
      Epub 2011 Aug 19.


PMID- 21854810
OWN - NLM
STAT- MEDLINE
DCOM- 20120124
LR  - 20211020
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 225
IP  - 2
DP  - 2011 Dec 1
TI  - Threshold of adulthood for the onset of nicotine self-administration in male and 
      female rats.
PG  - 473-81
LID - 10.1016/j.bbr.2011.08.005 [doi]
AB  - The great majority of tobacco addiction begins during adolescence. More heavily
      addicted smokers begin smoking earlier, but differentiating the neurobehavioral
      impact of nicotine self-administration during adolescence from self-selection
      bias (whereby people more prone to heavy addiction also begin earlier) cannot be 
      ethically unconfounded in humans. The goals of this research were to determine
      the age threshold for the adult-like nicotine self-administration and determine
      sex differences. Male and female Sprague-Dawley rats were tested for nicotine
      self-administration starting at 4, 5, 6, 7, and 8 weeks of age in an operant FR1 
      schedule for IV nicotine (0.03 mg/kg/infusion) in 45-min sessions for 2 weeks,
      with 1 week of enforced abstinence and 1 week of resumed access. This study
      replicated our earlier work that nicotine self-administration was increased in
      adolescent vs. adult rats and that the effect was more pronounced in adolescent
      males, but the increased nicotine self-administration was more persistent in
      adolescent-onset females. The age threshold for adult-like behavior was 6-7 weeks
      of age. Adolescent-onset nicotine self-administration had persisting effects of
      eggaurated increases of nicotine self-administration when fixed-ratio
      requirements for self-administration were lowered. Female rats that had begun
      nicotine self-administration during adolescence showed exaggerated increases in
      nicotine self-administration after a switch back to FR1 from FR8, indicating a
      lessened control over their self-administration. Adolescent-onset nicotine
      self-administration was not found to potentiate cocaine self-administration.
      Adolescent-onset nicotine self-administration causes persistent increases in
      nicotine self-administration in female rats even after they reach adulthood and
      disrupts control over self-administration behavior.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Levin, Edward D
AU  - Levin ED
AD  - Department of Psychiatry and Behavioral Sciences, Duke University Medical Center,
      Durham, NC 27710, United States. edlevin@duke.edu
FAU - Slade, Susan
AU  - Slade S
FAU - Wells, Corinne
AU  - Wells C
FAU - Cauley, Marty
AU  - Cauley M
FAU - Petro, Ann
AU  - Petro A
FAU - Vendittelli, Analise
AU  - Vendittelli A
FAU - Johnson, Michael
AU  - Johnson M
FAU - Williams, Paul
AU  - Williams P
FAU - Horton, Kofi
AU  - Horton K
FAU - Rezvani, Amir H
AU  - Rezvani AH
LA  - eng
GR  - R01 DA015756/DA/NIDA NIH HHS/United States
GR  - R01 DA015756-05/DA/NIDA NIH HHS/United States
GR  - DA015756/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110811
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 6M3C89ZY6R (Nicotine)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Cocaine/administration & dosage/pharmacology
MH  - Conditioning, Operant/*drug effects
MH  - *Critical Period, Psychological
MH  - Estrus
MH  - Female
MH  - Male
MH  - Nicotine/administration & dosage/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reinforcement Schedule
MH  - Self Administration
MH  - Sex Characteristics
PMC - PMC3179820
MID - NIHMS322672
EDAT- 2011/08/23 06:00
MHDA- 2012/01/25 06:00
CRDT- 2011/08/23 06:00
PHST- 2011/06/17 00:00 [received]
PHST- 2011/08/03 00:00 [revised]
PHST- 2011/08/04 00:00 [accepted]
PHST- 2011/08/23 06:00 [entrez]
PHST- 2011/08/23 06:00 [pubmed]
PHST- 2012/01/25 06:00 [medline]
AID - S0166-4328(11)00594-8 [pii]
AID - 10.1016/j.bbr.2011.08.005 [doi]
PST - ppublish
SO  - Behav Brain Res. 2011 Dec 1;225(2):473-81. doi: 10.1016/j.bbr.2011.08.005. Epub
      2011 Aug 11.


PMID- 21854618
OWN - NLM
STAT- MEDLINE
DCOM- 20120131
LR  - 20211020
IS  - 1471-2296 (Electronic)
IS  - 1471-2296 (Linking)
VI  - 12
DP  - 2011 Aug 19
TI  - Knowledge of family health program practitioners in Brazil about sickle cell
      disease: a descriptive, cross-sectional study.
PG  - 89
LID - 10.1186/1471-2296-12-89 [doi]
AB  - BACKGROUND: Although sickle cell disease is an important public health problem in
      Brazil, there is a gap in the literature on the level of knowledge of primary
      health care professionals about the treatment and management of sickle cell
      disease. Therefore, this study aimed to evaluate the level of knowledge about
      sickle cell disease of physicians and nurses who work in the Family Health
      Program in a region of Brazil with a high prevalence of this disease. METHODS:
      This is a descriptive, cross-sectional study conducted at the municipality of
      Montes Claros, in the north of Minas Gerais, Brazil. Study participants included 
      96 physicians and nurses who work at the Family Health Program in an urban area
      of the city. Data was collected using an original, partially tested questionnaire
      based on health care check points for children with sickle cell disease
      established in educational protocols from the State Health Secretary of Minas
      Gerais and the Ministry of Health. The structured questionnaire contained 47
      questions addressing three axes: epidemiology (8 questions); clinical
      manifestations (13 questions); and management of children with sickle cell
      disease (26 questions). Knowledge was measured through mean correct responses to 
      proposed questions. Ethical principles were respected and this project was
      approved by the Committee of Ethics in Research. RESULTS: 59.4% (57) of the study
      participants were nurses and 40.6% (39) were physicians. The median length of
      training and median length of service in primary health care were 4.3 (2.8-8.0)
      years and 4.0 (2.0-7.1) years, respectively. The mean performance in knowledge
      tests was < 75%, with 5.7/8 (SD = 1.4) for the "epidemiology" questions; 8.6/13
      (SD = 2.2) for "clinical manifestations"; and 17.0/26 (SD = 2.9) for "management 
      of children with sickle cell disease" questions; resulting in a mean total of
      31.4/47 (SD = 5.10) correct responses. A statistically significant association
      was found between the number of correct responses and family health care
      qualifications (p = 0.015). CONCLUSION: There is an urgent need to improve
      primary health care professional training in the care of children with sickle
      cell disease.
FAU - Gomes, Ludmila M X
AU  - Gomes LM
AD  - Department of Nursing, State University of Montes Claros, Minas Gerais, Brazil.
      ludyxavier@yahoo.com.br
FAU - Vieira, Magda M
AU  - Vieira MM
FAU - Reis, Tatiana C
AU  - Reis TC
FAU - Barbosa, Thiago L A
AU  - Barbosa TL
FAU - Caldeira, Antonio P
AU  - Caldeira AP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110819
PL  - England
TA  - BMC Fam Pract
JT  - BMC family practice
JID - 100967792
SB  - IM
MH  - *Anemia, Sickle Cell/complications/epidemiology/physiopathology/therapy
MH  - Brazil/epidemiology
MH  - Child
MH  - Cross-Sectional Studies
MH  - Family Practice/education/*standards
MH  - Female
MH  - Health Care Surveys
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Male
MH  - Needs Assessment
MH  - Physicians, Primary Care/education
MH  - Prevalence
MH  - Primary Care Nursing
MH  - Quality of Health Care/*standards
MH  - Urban Health Services/organization & administration
MH  - Workforce
PMC - PMC3179714
EDAT- 2011/08/23 06:00
MHDA- 2012/02/01 06:00
CRDT- 2011/08/23 06:00
PHST- 2011/01/21 00:00 [received]
PHST- 2011/08/19 00:00 [accepted]
PHST- 2011/08/23 06:00 [entrez]
PHST- 2011/08/23 06:00 [pubmed]
PHST- 2012/02/01 06:00 [medline]
AID - 1471-2296-12-89 [pii]
AID - 10.1186/1471-2296-12-89 [doi]
PST - epublish
SO  - BMC Fam Pract. 2011 Aug 19;12:89. doi: 10.1186/1471-2296-12-89.


PMID- 21854275
OWN - NLM
STAT- MEDLINE
DCOM- 20111214
LR  - 20211020
IS  - 1097-9891 (Electronic)
IS  - 0095-2990 (Linking)
VI  - 37
IP  - 5
DP  - 2011 Sep
TI  - Research partnerships between academic institutions and American Indian and
      Alaska Native Tribes and organizations: effective strategies and lessons learned 
      in a multisite CTN study.
PG  - 333-8
LID - 10.3109/00952990.2011.596976 [doi]
AB  - BACKGROUND: Community Based and Tribally Based Participatory Research (CBPR/TPR) 
      are approaches that can be successful for developing ethical and effective
      research partnerships between academic institutions and Tribes and Native
      organizations. OBJECTIVES: The NIDA Clinical Trials Network funded a multi-site, 
      exploratory study using CBPR/TPR to begin to better understand substance abuse
      issues of concern to some Tribes and Native organizations as well as strengths
      and resources that exist in these communities to address these concerns.
      Attention was paid to the development and maintenance of research partnerships in
      each of the sites. METHODS: Each of the five partnerships is briefly described
      and common as well as unique challenges and successes are identified. RESULTS: A 
      summary of the common themes for developing these collaborative research efforts 
      is provided. CONCLUSION: True, collaborative research partnerships require a
      great deal of time and effort in order to develop mutual trust, understanding,
      knowledge, and collaboration that will guide research that is rigorous as well as
      ethical, effective, and culturally appropriate. SCIENTIFIC SIGNIFICANCE: As AIAN 
      communities become increasingly sophisticated partners in, and consumers of,
      research, CBPR and TPR are emerging as effective, ethical, culturally
      appropriate, and acceptable approaches. This can serve to improve the science we 
      engage in with AIAN communities, add to the scarce literature regarding AIAN
      communities, and better serve AIAN communities in addressing health disparities
      and improving health.
FAU - Thomas, Lisa Rey
AU  - Thomas LR
AD  - Alcohol and Drug Abuse Institute, University of Washington, Seattle, 98105-4631, 
      USA. lrthomas@u.washington.edu
FAU - Rosa, Carmen
AU  - Rosa C
FAU - Forcehimes, Alyssa
AU  - Forcehimes A
FAU - Donovan, Dennis M
AU  - Donovan DM
LA  - eng
GR  - U10 DA013714-05/DA/NIDA NIH HHS/United States
GR  - UL1 RR025014/RR/NCRR NIH HHS/United States
GR  - U10 DA015833/DA/NIDA NIH HHS/United States
GR  - U10 DA013714/DA/NIDA NIH HHS/United States
GR  - U10 DA015833-09/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - Am J Drug Alcohol Abuse
JT  - The American journal of drug and alcohol abuse
JID - 7502510
SB  - IM
MH  - Alaska
MH  - Community-Based Participatory Research/ethics/*organization & administration
MH  - *Community-Institutional Relations
MH  - Cooperative Behavior
MH  - Health Status Disparities
MH  - Humans
MH  - *Indians, North American
MH  - Research Design
PMC - PMC3465683
MID - NIHMS341527
EDAT- 2011/08/23 06:00
MHDA- 2011/12/15 06:00
CRDT- 2011/08/23 06:00
PHST- 2011/08/23 06:00 [entrez]
PHST- 2011/08/23 06:00 [pubmed]
PHST- 2011/12/15 06:00 [medline]
AID - 10.3109/00952990.2011.596976 [doi]
PST - ppublish
SO  - Am J Drug Alcohol Abuse. 2011 Sep;37(5):333-8. doi: 10.3109/00952990.2011.596976.


PMID- 21854235
OWN - NLM
STAT- MEDLINE
DCOM- 20111123
LR  - 20220316
IS  - 1037-6178 (Print)
IS  - 1037-6178 (Linking)
VI  - 38
IP  - 1-2
DP  - 2011 Apr-Jun
TI  - Factors associated with learning outcome of BSN in a blended learning
      environment.
PG  - 24-34
LID - 10.5172/conu.2011.38.1-2.24 [doi]
AB  - This paper is a report of a study to examine the influence of demographic,
      learning behavior and learning performance variables on learning outcomes of
      baccalaureate nursing students within a blended learning environment. A
      cross-sectional survey was conducted using the self-structured demographic
      questionnaire, case analysis attitude scale (CAAS), the case analysis
      self-evaluation scales (CASES), the metacognition scale (MS) and blended learning
      satisfaction scale (BLSS) to measure learning outcomes after the blended learning
      course. A total of 99 senior undergraduate nursing students currently studying at
      a public nursing college in Taiwan were eligible to participate in the study in
      2008. Data were analyzed by descriptive statistics and multiple linear
      regression. Univariate analysis showed significant associations between frequency
      of online dialogues, time spent on the internet, CAAS, and MS and scores on the
      ethical course. However, frequency of online dialogues, time spent on the
      internet, and the CAAS were significantly independent predictors for scores on
      the ethical course in the final model of multivariate analysis. The final model
      of the data analysis could account for 78% variances scores of ethical course
      (R(2) = 0.78 and adjusted R(2) = 0.77). It can be concluded from this study that 
      frequency of online dialogue, time spent on internet, and the CAAS score are all 
      useful predictors for learning outcome. In addition, blended learning was found
      to have contributed to learners' learning outcome by facilitating their
      metacognitive development and self-regulatory development. In blended learning
      courses, students have more responsibilities placed upon them than in traditional
      face-to-face learning environments. The first step of constructing a working
      blended learning model is to develop student-oriented teaching pedagogies that
      include face-to-face and online instruction, rather than just focusing on the
      provision of technical skills.
FAU - Hsu, Li-Ling
AU  - Hsu LL
AD  - National Taipei University of Nursing and Health Sciences, Taipei, Taiwan.
FAU - Hsieh, Suh-Ing
AU  - Hsieh SI
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Contemp Nurse
JT  - Contemporary nurse
JID - 9211867
MH  - Adult
MH  - Computer-Assisted Instruction
MH  - Cross-Sectional Studies
MH  - *Education, Nursing, Baccalaureate
MH  - *Educational Measurement
MH  - Ethics, Nursing/*education
MH  - Female
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Multivariate Analysis
MH  - Program Evaluation
MH  - Taiwan
MH  - Teaching/*methods
EDAT- 2011/08/23 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/08/23 06:00
PHST- 2011/08/23 06:00 [entrez]
PHST- 2011/08/23 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.5172/conu.2011.38.1-2.24 [doi]
AID - 10.5172/conu.2011.38.1-2.24 [pii]
PST - ppublish
SO  - Contemp Nurse. 2011 Apr-Jun;38(1-2):24-34. doi: 10.5172/conu.2011.38.1-2.24.


PMID- 21853890
OWN - NLM
STAT- MEDLINE
DCOM- 20110901
LR  - 20131121
IS  - 1351-5578 (Print)
IS  - 1351-5578 (Linking)
VI  - 18
IP  - 4
DP  - 2011
TI  - Methodological and ethical challenges in investigating the safety of medication
      administration.
PG  - 28-32
AB  - AIM: The aim of this article is to highlight some of the methodological and
      ethical challenges that the researcher faced when conducting a study of the
      safety of medication administration. BACKGROUND: Investigating a sensitive topic,
      such as the safety of medication administration, can be methodologically
      demanding, time-consuming and ethically challenging. Moreover, it can be
      particularly difficult to balance methodological with ethical and legal
      challenges. This article presents the considerations involved in the sampling,
      recruitment and ethical issues related to participants' involvement in a
      medication safety study. DATA SOURCES: The article draws on the methodological
      and ethical approaches related to one qualitative study that investigated the
      nurse's views of the organisational contributions toward the safety of medication
      administration in adult critical care. The study was completed in 2009.
      DISCUSSION: The study used a questionnaire to recruit the paticipants and this
      gave the researcher the advantage of being able to select critical care nurses
      from particular backgrounds, enriching the views and perspectives relating to the
      topic under investigation. Approaching the participants for 'expert' opinions,
      rather than 'error-makers', helped to established early rapport with the
      participants. Research rigour and data trustworthiness were demonstrated by
      several operational techniques, including providing a detailed account and
      justification for the research process. CONCLUSION: Research into patient safety 
      may have particular methodological and ethical challenges and therefore needs an 
      appropriate research approach to balance practicality, the participants'
      integrity and research rigour. IMPLICATIONS FOR PRACTICE AND RESEARCH It is
      anticipated that this approach will provide an insight into some challenges that 
      may arise in conducting patient safety research, providing a useful guide for
      others to consider in their future research.
FAU - Mansour, Mansour
AU  - Mansour M
AD  - Department of Acute Care, Faculty of Health and Social Care, Anglia Ruskin
      University, Chelmsford, UK. mansor.mansour@anglia.ac.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurse Res
JT  - Nurse researcher
JID - 9435953
RN  - 0 (Pharmaceutical Preparations)
MH  - Drug-Related Side Effects and Adverse Reactions
MH  - *Ethics
MH  - Humans
MH  - Patient Care Planning
MH  - Pharmaceutical Preparations/*administration & dosage
MH  - *Safety
MH  - Sample Size
EDAT- 2011/08/23 06:00
MHDA- 2011/09/02 06:00
CRDT- 2011/08/23 06:00
PHST- 2011/08/23 06:00 [entrez]
PHST- 2011/08/23 06:00 [pubmed]
PHST- 2011/09/02 06:00 [medline]
AID - 10.7748/nr2011.07.18.4.28.c8633 [doi]
PST - ppublish
SO  - Nurse Res. 2011;18(4):28-32. doi: 10.7748/nr2011.07.18.4.28.c8633.


PMID- 21853684
OWN - NLM
STAT- MEDLINE
DCOM- 20110906
LR  - 20110822
IS  - 1320-3185 (Print)
IS  - 1320-3185 (Linking)
VI  - 19
IP  - 1
DP  - 2011 Jul
TI  - Public opinion and ethics.
PG  - 25
FAU - Johnstone, Megan-Jane
AU  - Johnstone MJ
AD  - School of Nursing, Deakin University, Victoria.
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Aust Nurs J
JT  - Australian nursing journal (July 1993)
JID - 9317904
MH  - Decision Making/ethics
MH  - Democracy
MH  - Ethics, Nursing
MH  - Humans
MH  - *Morals
MH  - *Public Opinion
EDAT- 2011/08/23 06:00
MHDA- 2011/09/07 06:00
CRDT- 2011/08/23 06:00
PHST- 2011/08/23 06:00 [entrez]
PHST- 2011/08/23 06:00 [pubmed]
PHST- 2011/09/07 06:00 [medline]
PST - ppublish
SO  - Aust Nurs J. 2011 Jul;19(1):25.


PMID- 21852705
OWN - NLM
STAT- MEDLINE
DCOM- 20120130
LR  - 20181201
IS  - 1475-5793 (Electronic)
IS  - 0969-1413 (Linking)
VI  - 18
IP  - 2
DP  - 2011
TI  - Colorectal cancer screening, ethics and evidence-based public policy.
PG  - 103; author reply 103-4
LID - 10.1258/jms.2011.011061 [doi]
FAU - Braillon, Alain
AU  - Braillon A
LA  - eng
PT  - Letter
PT  - Comment
PL  - England
TA  - J Med Screen
JT  - Journal of medical screening
JID - 9433359
SB  - IM
CON - J Med Screen. 2011;18(1):18-23. PMID: 21536812
MH  - Colorectal Neoplasms/*diagnosis
MH  - *Feces
MH  - Female
MH  - Humans
MH  - Male
MH  - *Occult Blood
EDAT- 2011/08/20 06:00
MHDA- 2012/01/31 06:00
CRDT- 2011/08/20 06:00
PHST- 2011/08/20 06:00 [entrez]
PHST- 2011/08/20 06:00 [pubmed]
PHST- 2012/01/31 06:00 [medline]
AID - 18/2/103-a [pii]
AID - 10.1258/jms.2011.011061 [doi]
PST - ppublish
SO  - J Med Screen. 2011;18(2):103; author reply 103-4. doi: 10.1258/jms.2011.011061.


PMID- 21852568
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20111020
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 261
IP  - 2
DP  - 2011 Nov
TI  - Assessment of white matter microstructural integrity in children with syndromic
      craniosynostosis: a diffusion-tensor imaging study.
PG  - 534-41
LID - 10.1148/radiol.11101024 [doi]
AB  - PURPOSE: To assess whether architectural alterations exist in the white matter of
      patients with syndromic and complex craniosynostosis. MATERIALS AND METHODS: The 
      medical ethics committee approved this study. Written informed consent was
      obtained from parents or guardians before imaging. A prospective study was
      performed in children with syndromic and complex craniosynostosis aged 6-14
      years. Forty-five patients were included: four had Apert syndrome, 14 had
      Crouzon-Pfeiffer syndrome, eight had Muenke syndrome, 11 had Saethre-Chotzen
      syndrome, and eight had complex craniosynostosis. In addition, seven control
      subjects were evaluated. For diffusion-tensor imaging, an echo-planar sequence
      was used with a diffusion gradient (b = 1000 sec/mm(2)) applied in 25
      noncollinear directions. Regions of interest (ROIs) were placed in the following 
      white matter structures: pontine crossing tract, corticospinal tracts, medial
      cerebral peduncles, uncinate fasciculus (measured bilaterally), anterior
      commissure, frontal and occipital white matter (measured bilaterally), fornix,
      corpus callosum (measured in the genu and splenium), and corpus cingulum
      (measured bilaterally). Eigenvalues were measured in all ROIs and fractional
      anisotropy (FA) was calculated. RESULTS: Across all measured ROIs, FA values were
      generally lower in all patients combined than in the control subjects (P < .001).
      There were no significant differences among subgroups of patients. CONCLUSION:
      Diffusion-tensor imaging measurements of white matter tracts reveal significant
      white matter integrity differences between children with craniosynostosis and
      healthy control subjects. This could imply that the developmental delays seen in 
      these patients could be caused by the presence of a primary disorder of the white
      matter microarchitecture.
CI  - RSNA, 2011
FAU - Florisson, Joyce M G
AU  - Florisson JM
AD  - Department of Plastic, Reconstructive, and Hand Surgery, Erasmus Medical Center, 
      Sophia Children's Hospital, PO Box 2040, Room Ee 15.91, 3000 CA Rotterdam, The
      Netherlands. j.florisson@erasmusmc.nl
FAU - Dudink, Jeroen
AU  - Dudink J
FAU - Koning, Irene V
AU  - Koning IV
FAU - Hop, Wim C J
AU  - Hop WC
FAU - van Veelen, Marie-Lise C
AU  - van Veelen ML
FAU - Mathijssen, Irene M J
AU  - Mathijssen IM
FAU - Lequin, Maarten H
AU  - Lequin MH
LA  - eng
PT  - Journal Article
DEP - 20110818
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adolescent
MH  - Analysis of Variance
MH  - Case-Control Studies
MH  - Child
MH  - Craniosynostoses/*pathology
MH  - Diffusion Magnetic Resonance Imaging/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Nerve Fibers, Myelinated/*pathology
MH  - Prospective Studies
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Statistics, Nonparametric
EDAT- 2011/08/20 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/08/20 06:00
PHST- 2011/08/20 06:00 [entrez]
PHST- 2011/08/20 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - radiol.11101024 [pii]
AID - 10.1148/radiol.11101024 [doi]
PST - ppublish
SO  - Radiology. 2011 Nov;261(2):534-41. doi: 10.1148/radiol.11101024. Epub 2011 Aug
      18.


PMID- 21852325
OWN - NLM
STAT- MEDLINE
DCOM- 20111220
LR  - 20161125
IS  - 1479-6805 (Electronic)
IS  - 0022-0795 (Linking)
VI  - 211
IP  - 2
DP  - 2011 Nov
TI  - Pluripotency-associated stem cell marker expression in proliferative cell
      cultures derived from adult human pancreas.
PG  - 169-76
LID - 10.1530/JOE-11-0123 [doi]
AB  - The source of new beta-cells in adult human pancreas remains incompletely
      elucidated with recent studies on rodents providing evidence for neogenesis from 
      progenitor cells in addition to self-replication. The aim of this study was to
      investigate the expression of pluripotency-associated stem cell markers in
      proliferative cultures derived from adult human pancreas. Human pancreatic tissue
      was obtained from deceased donors following ethical approval and relative
      consent. Islet-enriched fraction was separated from the retrieved organ by
      digestion and density gradient centrifugation. Dissociated cells were seeded in
      adherent culture forming proliferative 'islet survivor cells' (ISCs). These were 
      characterised at fifth passage by RT-PCR, immunofluorescence staining, FACS,
      western blot and transfection studies with an OCT4 promoter-driven reporter.
      Nuclear expression of the pluripotency-associated stem cell marker complex
      OCT4/SOX2/NANOG was confirmed in ISCs. The phenotype constituted approximately 8%
      of the overall population. OCT4 biosynthesis was confirmed by western blot and
      activation of an exogenous OCT4 promoter. Co-expression of
      pluripotency-associated markers has been confirmed in proliferative primary cells
      derived from adult human pancreas. Further studies are required to elucidate
      whether these cells possess functional stem cell characteristics and assess
      potential for differentiation into pancreatic cell lineages including new
      beta-cells.
FAU - White, Michael G
AU  - White MG
AD  - Diabetes Research Group, Medical School, Institute of Cellular Medicine, North
      East Stem Cell Institute, Newcastle University, UK.
FAU - Al-Turaifi, Hussain R
AU  - Al-Turaifi HR
FAU - Holliman, Graham N
AU  - Holliman GN
FAU - Aldibbiat, Ali
AU  - Aldibbiat A
FAU - Mahmoud, Aiman
AU  - Mahmoud A
FAU - Shaw, James A M
AU  - Shaw JA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110818
PL  - England
TA  - J Endocrinol
JT  - The Journal of endocrinology
JID - 0375363
RN  - 0 (Biomarkers)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (NANOG protein, human)
RN  - 0 (Nanog Homeobox Protein)
RN  - 0 (Octamer Transcription Factor-3)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 0 (SOX2 protein, human)
RN  - 0 (SOXB1 Transcription Factors)
RN  - 147336-22-9 (Green Fluorescent Proteins)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Blotting, Western
MH  - Cell Line, Tumor
MH  - Cell Nucleus/metabolism
MH  - *Cell Proliferation
MH  - Cells, Cultured
MH  - Embryonic Stem Cells/cytology/metabolism
MH  - Flow Cytometry
MH  - Fluorescent Antibody Technique
MH  - Gene Expression
MH  - Green Fluorescent Proteins/genetics/metabolism
MH  - Homeodomain Proteins/genetics/metabolism
MH  - Humans
MH  - Nanog Homeobox Protein
MH  - Octamer Transcription Factor-3/genetics/metabolism
MH  - Pancreas/*cytology
MH  - Pluripotent Stem Cells/*cytology/*metabolism
MH  - Primary Cell Culture
MH  - Recombinant Fusion Proteins/genetics/metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - SOXB1 Transcription Factors/genetics/metabolism
EDAT- 2011/08/20 06:00
MHDA- 2011/12/21 06:00
CRDT- 2011/08/20 06:00
PHST- 2011/08/20 06:00 [entrez]
PHST- 2011/08/20 06:00 [pubmed]
PHST- 2011/12/21 06:00 [medline]
AID - JOE-11-0123 [pii]
AID - 10.1530/JOE-11-0123 [doi]
PST - ppublish
SO  - J Endocrinol. 2011 Nov;211(2):169-76. doi: 10.1530/JOE-11-0123. Epub 2011 Aug 18.


PMID- 21851547
OWN - NLM
STAT- MEDLINE
DCOM- 20120423
LR  - 20120220
IS  - 1464-410X (Electronic)
IS  - 1464-4096 (Linking)
VI  - 109
IP  - 5
DP  - 2012 Mar
TI  - Expression of the tumour antigen T21 is up-regulated in prostate cancer and is
      associated with tumour stage.
PG  - 796-805
LID - 10.1111/j.1464-410X.2011.10407.x [doi]
AB  - OBJECTIVES: * To define the expression pattern of the tumour antigen T21 at the
      protein level in prostate tissues, prostate cell lines and a panel of normal
      tissues. * To correlate the expression pattern of T21 in prostate cancer with
      clinical parameters. PATIENTS AND METHODS: * Tissue samples were collected from
      79 patients presenting at clinic with either prostate cancer (63 patients) or
      benign prostatic hyperplasia (BPH, 16 patients). * A tissue microarray (TMA) was 
      constructed from 44 of the prostate cancer tissues and areas of benign disease
      (43 patients) from these tissues were also included on the TMA. The remaining
      tissues (prostate cancer 19 patients and BPH 16 patients) were mounted fresh
      frozen onto cork boards and sectioned. * Full ethical approval was granted for
      all aspects of the study and informed patient consent was taken before tissue
      collection. * Immunohistochemistry was used on the prostate tumour TMA, the
      normal tissue TMA and the fresh-frozen prostate tissues. Fluorescent microscopy
      and flow cytometry was performed on prostate cell lines. RESULTS: * Expression of
      T21 was highly restricted within normal tissues with only the stomach, ovary,
      breast and prostate having detectable T21 expression. * T21 was significantly
      over-expressed in prostate cancer glands compared with benign tissue and was
      present in >80% of the malignant specimens analysed. * Increased expression was
      positively correlated to pathological stage of prostate tumours. * Additionally, 
      T21 was associated with Gleason grade and prostate-specific antigen recurrence,
      although statistical significance was not reached in this restricted cohort of
      patients. CONCLUSION: * Taken together these results show that T21 is a potential
      new biomarker for advanced disease and that elevated levels of T21 appear
      relevant to prostate cancer development.
CI  - (c) 2011 THE AUTHORS. BJU INTERNATIONAL (c) 2011 BJU INTERNATIONAL.
FAU - Miles, Amanda K
AU  - Miles AK
AD  - The John van Geest Cancer Research Centre, School of Science and Technology,
      Nottingham Trent Universitythe, Nottingham, UK. Amanda.Miles@ntu.ac.uk
FAU - Rogers, Alistair
AU  - Rogers A
FAU - McCulloch, Thomas
AU  - McCulloch T
FAU - Hodi, Zsolt
AU  - Hodi Z
FAU - McArdle, Stephanie
AU  - McArdle S
FAU - Bishop, Michael
AU  - Bishop M
FAU - Rees, Robert C
AU  - Rees RC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110818
PL  - England
TA  - BJU Int
JT  - BJU international
JID - 100886721
RN  - 0 (HIV Envelope Protein gp41)
RN  - 0 (Peptide Fragments)
RN  - 0 (peptide T21)
SB  - IM
MH  - HIV Envelope Protein gp41/*biosynthesis
MH  - Humans
MH  - Male
MH  - Neoplasm Staging
MH  - Peptide Fragments/*biosynthesis
MH  - Prostatic Neoplasms/*metabolism/*pathology
MH  - *Up-Regulation
EDAT- 2011/08/20 06:00
MHDA- 2012/04/24 06:00
CRDT- 2011/08/20 06:00
PHST- 2011/08/20 06:00 [entrez]
PHST- 2011/08/20 06:00 [pubmed]
PHST- 2012/04/24 06:00 [medline]
AID - 10.1111/j.1464-410X.2011.10407.x [doi]
PST - ppublish
SO  - BJU Int. 2012 Mar;109(5):796-805. doi: 10.1111/j.1464-410X.2011.10407.x. Epub
      2011 Aug 18.


PMID- 21851511
OWN - NLM
STAT- MEDLINE
DCOM- 20120131
LR  - 20121119
IS  - 1365-2753 (Electronic)
IS  - 1356-1294 (Linking)
VI  - 17
IP  - 5
DP  - 2011 Oct
TI  - Improved health or improved decision making? The ethical goals of EBM.
PG  - 957-63
LID - 10.1111/j.1365-2753.2011.01743.x [doi]
AB  - Evidence-based medicine (EBM) is frequently portrayed as a value-free approach to
      knowing what kinds of treatment 'really work.' Since practitioners should help
      patients to improve their health, and EBM tells us which interventions will work,
      then it follows that we must practice EBM, offering only those interventions
      supported by evidence. The primary goal of EBM, then, is an ethical one - to
      improve health. More recently, EBM's authors have also committed themselves to
      'shared decision making' in which evidence plays a role in the clinical
      encounter, but where patients, motivated by their own values, should have final
      decision-making authority. Envisioned this way, strengthening the informed
      consent process, rather than improved health per se, is viewed as the goal of
      EBM. In this paper, I will explore this shift in EBM's ethics from the goal of
      improved health towards the goal of strengthened informed consent. Drawing upon
      data from a qualitative enquiry of scholars involved in the development of EBM, I
      will argue that EBM is now committed to both of these ethical goals. Where they
      conflict, the aim of the intervention will determine which goal practitioners
      should pursue. Having increased the ethical complexity of EBM, we are left with
      the question of whether EBM would still be judged a success if it did not lead to
      much in the way of improvements in health, but primarily strengthened informed
      consent. This paper will conclude by arguing that this more nuanced version of
      EBM's ethics accurately reflects the dynamics of real clinical practice but
      undermines the original, perceived need for EBM.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Gupta, Mona
AU  - Gupta M
AD  - Departement de Psychiatrie, Universite de Montreal, Hopital Saint-Luc du CHUM,
      Montreal, Quebec, Canada. mona.gupta@utoronto.ca
LA  - eng
PT  - Journal Article
DEP - 20110818
PL  - England
TA  - J Eval Clin Pract
JT  - Journal of evaluation in clinical practice
JID - 9609066
SB  - IM
CIN - J Eval Clin Pract. 2012 Oct;18(5):1110. PMID: 22995018
MH  - *Decision Making
MH  - *Ethics, Clinical
MH  - Evidence-Based Medicine/*ethics/organization & administration
MH  - Health Status
MH  - Humans
MH  - Informed Consent/*ethics
MH  - *Patient Participation
EDAT- 2011/08/20 06:00
MHDA- 2012/02/01 06:00
CRDT- 2011/08/20 06:00
PHST- 2011/08/20 06:00 [entrez]
PHST- 2011/08/20 06:00 [pubmed]
PHST- 2012/02/01 06:00 [medline]
AID - 10.1111/j.1365-2753.2011.01743.x [doi]
PST - ppublish
SO  - J Eval Clin Pract. 2011 Oct;17(5):957-63. doi: 10.1111/j.1365-2753.2011.01743.x. 
      Epub 2011 Aug 18.


PMID- 21851466
OWN - NLM
STAT- MEDLINE
DCOM- 20120105
LR  - 20110819
IS  - 1440-1819 (Electronic)
IS  - 1323-1316 (Linking)
VI  - 65
IP  - 5
DP  - 2011 Aug
TI  - Necessity for ethical consideration of research in the aftermath of disaster.
PG  - 535-6
LID - 10.1111/j.1440-1819.2011.02238.x [doi]
FAU - Iijima, Yoshihiko
AU  - Iijima Y
FAU - Aleksic, Branko
AU  - Aleksic B
FAU - Ozaki, Norio
AU  - Ozaki N
LA  - eng
PT  - Letter
PL  - Australia
TA  - Psychiatry Clin Neurosci
JT  - Psychiatry and clinical neurosciences
JID - 9513551
SB  - IM
MH  - *Disasters
MH  - Earthquakes
MH  - *Ethics, Research
MH  - Humans
MH  - Japan
EDAT- 2011/08/20 06:00
MHDA- 2012/01/06 06:00
CRDT- 2011/08/20 06:00
PHST- 2011/08/20 06:00 [entrez]
PHST- 2011/08/20 06:00 [pubmed]
PHST- 2012/01/06 06:00 [medline]
AID - 10.1111/j.1440-1819.2011.02238.x [doi]
PST - ppublish
SO  - Psychiatry Clin Neurosci. 2011 Aug;65(5):535-6. doi:
      10.1111/j.1440-1819.2011.02238.x.


PMID- 21851380
OWN - NLM
STAT- MEDLINE
DCOM- 20120530
LR  - 20220409
IS  - 1365-2648 (Electronic)
IS  - 0309-2402 (Linking)
VI  - 68
IP  - 3
DP  - 2012 Mar
TI  - A Steinian approach to an empathic understanding of hope among patients and
      clinicians in the culture of palliative care.
PG  - 686-94
LID - 10.1111/j.1365-2648.2011.05793.x [doi]
AB  - AIM: This article presents a discussion of empathy in the context of human
      person, reason and hopes in the clinical setting. BACKGROUND: Empathy was
      introduced to nursing as part of an ethical and philosophical foundation for
      caring. It helped to solve the tension and meet the demands that empathy placed
      upon nursing practice. DATA SOURCES: This article is based on two studies
      undertaken between 2008 and 2010 to understand the concept of hope and empathy
      among people with terminal cancer and doctors who care for them. Doctoral
      dissertations and theses of Edith Stein (1916-1917), Marianne Sawicki [Body, Text
      and Science. The Literary of Investigative Practices and the Phenomenology of
      Edith Stein (1997) Kluwer Academic Publisher, Dordrecht], and Sister M. Judith
      Parsons (2005) have been used to examine: 'the essence of acts of empathy', 'the 
      constitution of the psycho-physical individual' and 'empathy as understanding of 
      intellectual persons'. CINAHL, MEDLINE and PROQUEST have provided further
      supporting data. Discussion. Steinian empathy requires that we use affective
      resonance, cognitive understanding and distance, as we grasp another person's
      emotional and situational reality while in the caring role as nurses.
      Implications for current nursing. Steinian empathy is about recognizing a lived
      experience and standing side-by-side with that person. Nurses can transmit this
      knowledge to enable and support courage and wisdom to reduce feelings of
      helplessness when caring for people with terminal illness. CONCLUSION: Not only
      is empathy a safe and permissible emotion, it is the linchpin to a caring
      patient-nurse relationship and we must embrace this.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Richardson, Kate
AU  - Richardson K
AD  - Deakin University, Melbourne, Australia. katerichardson@xtra.co.nz
FAU - Macleod, Rod
AU  - Macleod R
FAU - Kent, Bridie
AU  - Kent B
LA  - eng
PT  - Journal Article
DEP - 20110818
PL  - England
TA  - J Adv Nurs
JT  - Journal of advanced nursing
JID - 7609811
SB  - IM
MH  - *Empathy
MH  - Female
MH  - Humans
MH  - Intuition
MH  - *Nurse's Role
MH  - *Nurse-Patient Relations
MH  - *Palliative Care
MH  - *Philosophy, Nursing
MH  - Qualitative Research
MH  - Terminally Ill/psychology
MH  - Theory of Mind
EDAT- 2011/08/20 06:00
MHDA- 2012/05/31 06:00
CRDT- 2011/08/20 06:00
PHST- 2011/08/20 06:00 [entrez]
PHST- 2011/08/20 06:00 [pubmed]
PHST- 2012/05/31 06:00 [medline]
AID - 10.1111/j.1365-2648.2011.05793.x [doi]
PST - ppublish
SO  - J Adv Nurs. 2012 Mar;68(3):686-94. doi: 10.1111/j.1365-2648.2011.05793.x. Epub
      2011 Aug 18.


PMID- 21850978
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20191112
IS  - 1145-0762 (Print)
IS  - 1145-0762 (Linking)
VI  - 22
IP  - 1
DP  - 2011 Mar-Jun
TI  - [The foundation of research ethics in community law].
PG  - 187-203, 218
AB  - The creation of the European Community by the Treaty of Rome in 1957 marked the
      beginning of the efforts to coordinate and harmonize national policies in many
      strategic sectors with high economic value, among them several aspects of
      scientific research. The European Union Law, formerly known as European Community
      law, now includes a range of ethical principles that apply to research projects
      developed with the financial support of the European Union. Which were the steps 
      in the integration of the ethics of sciences in the context of the Union? This
      article aims to study first, what were, and what are the legal bases of the
      integration of the ethical dimension of researches in life sciences by the
      European Union and, secondly, the institutional organisation that has been set up
      in order to discuss the development of common ethical norms, especially bioethics
      one, and in order to apply these rules which respect national particularities. In
      this regard, we analyse the relevant legal texts providing a foundation for the
      creation of a European bio-law and we give an overview of the European
      institutions' activity in the field of bioethics by looking particularly the
      health research field.
FAU - Chassang, Gauthier
AU  - Chassang G
AD  - UMR Inserm, Universite Paul Sabatier, Unite 558, Faculte de medecine, Toulouse.
      gauthier.chassang@gmail.com
FAU - Rial-Sebbag, Emmanuelle
AU  - Rial-Sebbag E
FAU - Cambon-Thomsen, Anne
AU  - Cambon-Thomsen A
LA  - fre
PT  - English Abstract
PT  - Historical Article
PT  - Journal Article
TT  - Les fondements de l'ethique de la recherche en droit communautaire.
PL  - France
TA  - J Int Bioethique
JT  - Journal international de bioethique = International journal of bioethics
JID - 9015754
SB  - IM
MH  - Biomedical Research/*legislation & jurisprudence
MH  - *Ethics, Research
MH  - European Union
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Public Policy
EDAT- 2011/08/20 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/08/20 06:00
PHST- 2011/08/20 06:00 [entrez]
PHST- 2011/08/20 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 10.3917/jib.221.0185 [doi]
PST - ppublish
SO  - J Int Bioethique. 2011 Mar-Jun;22(1):187-203, 218. doi: 10.3917/jib.221.0185.


PMID- 21850976
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20191112
IS  - 1145-0762 (Print)
IS  - 1145-0762 (Linking)
VI  - 22
IP  - 1
DP  - 2011 Mar-Jun
TI  - Nanomaterials and the environmental risk: is there some room left for ethics and 
      law?
PG  - 157-72, 216
AB  - How legitimate may be the concern posed by the nanotechnologies for health and
      environment,this effort for reaching a better knowledge of the biotoxicity of
      nanomaterials is not enough. As Pr Didier Sicard noted, we believe that the
      ethical reflection should not be the good conscience that may help science in
      getting rid of social fears. But the ethical reflection is there also to discuss 
      taboo issues in the perspective of a better societal understanding.
FAU - Byk, Christian
AU  - Byk C
AD  - International Association of Law, Ethics and Science.
LA  - eng
PT  - Journal Article
PL  - France
TA  - J Int Bioethique
JT  - Journal international de bioethique = International journal of bioethics
JID - 9015754
SB  - IM
MH  - *Environmental Health
MH  - Humans
MH  - *Nanostructures
MH  - Nanotechnology/*ethics/*legislation & jurisprudence
MH  - *Public Health
EDAT- 2011/08/20 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/08/20 06:00
PHST- 2011/08/20 06:00 [entrez]
PHST- 2011/08/20 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 10.3917/jib.221.0157 [doi]
PST - ppublish
SO  - J Int Bioethique. 2011 Mar-Jun;22(1):157-72, 216. doi: 10.3917/jib.221.0157.


PMID- 21850974
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20110819
IS  - 1145-0762 (Print)
IS  - 1145-0762 (Linking)
VI  - 22
IP  - 1
DP  - 2011 Mar-Jun
TI  - Nanotechnology and environmental ethics.
PG  - 137-43, 214-5
AB  - It seems that the relation between human and nature is not direct, but mediated
      by the technology. Therefore, it seems that characteristics of the technology
      defines the relation. If this is true, the problem is whether new technology
      always makes new relation or not. In this paper I take a brief look at the
      relation between technology in general and the environmental crisis from the
      ethical perspective. And then, I investigate the concept of responsible
      development and the principle of stewardship that is adopted in two reports
      concerning nanotechnologies. Through these explorations, an ethical stance on the
      application of nanotechnology is proposed.
FAU - Tomoki, Kihira
AU  - Tomoki K
AD  - Hyogo University of Health Sciences. kihira@ares.eonet.ne.jp
LA  - eng
PT  - Journal Article
PL  - France
TA  - J Int Bioethique
JT  - Journal international de bioethique = International journal of bioethics
JID - 9015754
SB  - IM
MH  - *Environmental Health
MH  - Humans
MH  - Nanotechnology/*ethics
MH  - Social Responsibility
EDAT- 2011/08/20 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/08/20 06:00
PHST- 2011/08/20 06:00 [entrez]
PHST- 2011/08/20 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
PST - ppublish
SO  - J Int Bioethique. 2011 Mar-Jun;22(1):137-43, 214-5.


PMID- 21850971
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20110819
IS  - 1145-0762 (Print)
IS  - 1145-0762 (Linking)
VI  - 22
IP  - 1
DP  - 2011 Mar-Jun
TI  - Neuroscience and nanotechnologies in Japan--beyond the hope and hype of
      converging technologies.
PG  - 91-7, 210-1
AB  - Nanotechnologies are often said to be "converging" with other technologies like
      biotechnology, information technology, and cognitive science. And so-called "NBIC
      convergence" is thought to enable "enhancement" of human performance. First, I
      classify various kinds of enhancement. Second, I focus on the "cybernetic
      enhancement," to which nanotechnologies are supposed to contribute, and analyze
      the connection and integration of humans with machines, which could lead to the
      cyborgization of human beings. Third, I examine the portrayal of robot/cyborg
      technology in Japanese popular media, point out the tendency to empathy or
      ensoulment concerning robots/cyborgs, and raise the question of "ethical issues
      of ethical enhancement." Fourth, I compare nanotechnologies with neurotechnology 
      and criticize the hype of "converging technologies."
FAU - Mushiaki, Shigeru
AU  - Mushiaki S
AD  - Faculty of Human Studies, Shujitsu University, Japan.
LA  - eng
PT  - Journal Article
PL  - France
TA  - J Int Bioethique
JT  - Journal international de bioethique = International journal of bioethics
JID - 9015754
SB  - IM
MH  - Cybernetics
MH  - Humans
MH  - Japan
MH  - Mass Media
MH  - *Nanotechnology
MH  - *Neurosciences
EDAT- 2011/08/20 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/08/20 06:00
PHST- 2011/08/20 06:00 [entrez]
PHST- 2011/08/20 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
PST - ppublish
SO  - J Int Bioethique. 2011 Mar-Jun;22(1):91-7, 210-1.


PMID- 21850969
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20191112
IS  - 1145-0762 (Print)
IS  - 1145-0762 (Linking)
VI  - 22
IP  - 1
DP  - 2011 Mar-Jun
TI  - The nanotech R&D situation in Japan and ethics of nanotechnology.
PG  - 57-69, 208
AB  - The aim of this paper is to introduce some characteristics of the historical as
      well as current situation of nanotech research and development in Japan in
      particular including regulations, and to discuss how ethical issues of
      nanotechnology should be addressed or how the ethics of nanotechnology should be 
      constructed to fit the situation. The first part will center around the strength 
      and weakness of Japan's nanotech R&D (research and development) and new
      circumstances which nanotechnology has prompted in Japan and alongside which
      nanotechnology has arrived (especially interdisciplinarity). The following
      prescriptive argument will, based on the descriptive account, question how to
      address ethical issues of nanotechnology, taking into consideration the nature of
      nanotech R&D, namely continuity, uniqueness, international dimension and
      political intervention, citing the example of the pharmaceutical industry. I will
      argue that international cooperation in the form of mutual reference to,
      replication of and the integration of guidelines and regulations, can enhance
      cost-effectiveness to ensure the comprehensiveness of regulatory measures.
FAU - Kato, Yutaka
AU  - Kato Y
AD  - Graduate School of Medicine, Osaka University.
LA  - eng
PT  - Journal Article
PL  - France
TA  - J Int Bioethique
JT  - Journal international de bioethique = International journal of bioethics
JID - 9015754
SB  - IM
MH  - Humans
MH  - Japan
MH  - Nanotechnology/*ethics
MH  - Politics
MH  - *Research
EDAT- 2011/08/20 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/08/20 06:00
PHST- 2011/08/20 06:00 [entrez]
PHST- 2011/08/20 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 10.3917/jib.221.0057 [doi]
PST - ppublish
SO  - J Int Bioethique. 2011 Mar-Jun;22(1):57-69, 208. doi: 10.3917/jib.221.0057.


PMID- 21850968
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20191112
IS  - 1145-0762 (Print)
IS  - 1145-0762 (Linking)
VI  - 22
IP  - 1
DP  - 2011 Mar-Jun
TI  - Cultural diversity in nanotechnology ethics.
PG  - 37-55, 207
AB  - Along with the rapid worldwide advance of nanotechnology, debates on associated
      ethical issues have spread from local to international levels. However unlike
      science and engineering issues, international perceptions of ethical issues are
      very diverse. This paper provides an analysis of how sociocultural factors such
      as language, cultural heritage, economics and politics can affect how people
      perceive ethical issues of nanotechnology. By attempting to clarify the
      significance of sociocultural issues in ethical considerations my aim is to
      support the ongoing international dialogue on nanotechnology. At the same time I 
      pose the general question of ethical relativism in engineering ethics, that is to
      say whether or not different ethical views are irreconcilable on a fundamental
      level.
FAU - Schummer, Joachim
AU  - Schummer J
AD  - University of Hannover, Germany. js@hyle.org
LA  - eng
PT  - Journal Article
PL  - France
TA  - J Int Bioethique
JT  - Journal international de bioethique = International journal of bioethics
JID - 9015754
SB  - IM
MH  - *Cultural Diversity
MH  - Humans
MH  - Nanotechnology/economics/*ethics
MH  - Politics
MH  - Terminology as Topic
EDAT- 2011/08/20 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/08/20 06:00
PHST- 2011/08/20 06:00 [entrez]
PHST- 2011/08/20 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 10.3917/jib.221.0037 [doi]
PST - ppublish
SO  - J Int Bioethique. 2011 Mar-Jun;22(1):37-55, 207. doi: 10.3917/jib.221.0037.


PMID- 21850967
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20110819
IS  - 1145-0762 (Print)
IS  - 1145-0762 (Linking)
VI  - 22
IP  - 1
DP  - 2011 Mar-Jun
TI  - Nanotechnologies, bioethics and human dignity.
PG  - 17-36, 206
AB  - Nanoscale science, research, and technology present a complex set of
      circumstances. First of all, this field involves many different subjects,
      including biology, chemistry, physics, and environment sciences. Secondly,
      although scientists are working increasingly at a molecular level, nanotechnology
      is about much more than a reduction of scale. Indeed, nanoscience and
      Nanotechnologies offer an unprecedented ability to control and manipulate nature,
      offering hope for progress. Ethical perspectives vary considerably in this field,
      but commentators and researchers share a concern about a specific worrisome
      issue: the lack of appropriate ethical and legal principles and processes
      (associated with issues including health risks, human body manipulation, and
      private life violation), to guide nanotechnological R&D, commercialization, and
      final use. Some authors partially reject this concern by suggesting that
      Nanoscience and Nanotechnologies do not constitute an autonomous category, and
      that they are instead just the operative result of combining other traditional
      areas of study. However the nanotechnological debate brings up the semantic and
      content issues of bioethics and foments a contentious discussion emphasizing
      human dignity. Issues include enhancement versus therapeutic intervention,
      traceability versus privacy, and societal benefits versus risks. From these
      preliminary considerations, we will move on to discuss (I) the traditional,
      although still controversial, relationship between bioethics and human dignity,
      and (II) return to the subject of nanotechnology. We will discuss how today in
      Europe, although still indefinite, the principle of respect for human dignity is 
      a welcomed contributor to "ethical vigilance" about the uncertain development of 
      new nano-scale technologies. We will also note how U.S. strategy in this regard
      is simply lacking and appears only as a purely discursive "key issue in long term
      ".
FAU - Visciano, Silvia
AU  - Visciano S
AD  - Universite de Foggia (Italie), Universite Paris I Pantheon-Sorbonne.
LA  - eng
PT  - Journal Article
PL  - France
TA  - J Int Bioethique
JT  - Journal international de bioethique = International journal of bioethics
JID - 9015754
SB  - IM
MH  - Bioethical Issues
MH  - Humans
MH  - Nanotechnology/*ethics
MH  - *Personhood
EDAT- 2011/08/20 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/08/20 06:00
PHST- 2011/08/20 06:00 [entrez]
PHST- 2011/08/20 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
PST - ppublish
SO  - J Int Bioethique. 2011 Mar-Jun;22(1):17-36, 206.


PMID- 21850229
OWN - NLM
STAT- MEDLINE
DCOM- 20120202
LR  - 20211020
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 6
IP  - 8
DP  - 2011
TI  - HIV pre-exposure prophylaxis (PrEP)--a quantitative ethics appraisal.
PG  - e22497
LID - 10.1371/journal.pone.0022497 [doi]
AB  - BACKGROUND: There is now strong evidence that preventive oral antiretroviral
      therapy can moderately reduce likelihood of HIV infection. This concept is called
      HIV pre-exposure prophylaxis (PrEP). Premature closures of some previous PrEP
      clinical trials, secondary to ethical concerns, did not stop research. We aimed
      to appraise the extent of ethics considerations reporting in PrEP study
      documents. METHODS: We conducted a systematic quantitative ethics appraisal,
      grounded in PrEP literature and using eight principles proposed by Ezechiel
      Emanuel. We developed an a priori checklist of 101 evidence-based ethics items.
      We obtained protocols for eleven of nineteen clinical controlled studies
      identified. Two reviewers independently appraised study documents against the
      checklist. Ethics appraisal was synthesized using adjusted percentages of items
      reported. RESULTS: On average, 58% of the 101 ethics items were mentioned or
      addressed in documents, with variations noted both across studies and across
      principles. Considerations pertaining to social value were least reported (43% of
      checklist items, on average) whereas considerations related to informed consent
      and favorable risk-benefit ratio were most reported (75% of checklist items, on
      average). DISCUSSION: Some PrEP studies reportedly address more ethics
      considerations than others but, overall, ethics considerations reporting could be
      much improved. While this review does not allow us to comment on the actual
      execution of HIV PrEP trials, it is a reminder that optimism generated by
      potentially effective interventions should not overshadow the importance of
      ethics in research design and development. Improving ethics reporting might
      improve the perceived value of PrEP research and subsequent data.
FAU - Kokolo, Madzouka B
AU  - Kokolo MB
AD  - Ottawa Hospital Research Institute, Clinical Epidemiology Programme, Ottawa,
      Ontario, Canada. mkokolo@ohri.ca
FAU - Fergusson, Dean A
AU  - Fergusson DA
FAU - Cameron, D William
AU  - Cameron DW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110805
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Anti-Retroviral Agents)
SB  - IM
MH  - Anti-Retroviral Agents/*therapeutic use
MH  - Biomedical Research/*ethics
MH  - Clinical Trials as Topic
MH  - HIV Infections/*prevention & control
MH  - Humans
MH  - Randomized Controlled Trials as Topic
PMC - PMC3151244
EDAT- 2011/08/19 06:00
MHDA- 2012/02/03 06:00
CRDT- 2011/08/19 06:00
PHST- 2011/04/07 00:00 [received]
PHST- 2011/06/24 00:00 [accepted]
PHST- 2011/08/19 06:00 [entrez]
PHST- 2011/08/19 06:00 [pubmed]
PHST- 2012/02/03 06:00 [medline]
AID - 10.1371/journal.pone.0022497 [doi]
AID - PONE-D-11-06369 [pii]
PST - ppublish
SO  - PLoS One. 2011;6(8):e22497. doi: 10.1371/journal.pone.0022497. Epub 2011 Aug 5.


PMID- 21850045
OWN - NLM
STAT- MEDLINE
DCOM- 20111017
LR  - 20211020
IS  - 1471-0064 (Electronic)
IS  - 1471-0056 (Linking)
VI  - 12
IP  - 9
DP  - 2011 Aug 18
TI  - Advances in prenatal screening: the ethical dimension.
PG  - 657-63
LID - 10.1038/nrg3036 [doi]
AB  - Prenatal screening strategies are undergoing rapid changes owing to the
      introduction of new testing techniques. The overall tendency is towards
      broadening the scope of prenatal testing through increasingly sensitive
      ultrasound scans and genome-wide molecular tests. In addition, non-invasive
      prenatal diagnosis is likely to be introduced in the near future. These
      developments raise important ethical questions concerning meaningful reproductive
      choice, the autonomy rights of future children, equity of access and the
      proportionality of testing.
FAU - de Jong, Antina
AU  - de Jong A
AD  - Department of Health, Ethics and Society, Maastricht University, PO BOX 616, 6200
      MD Maastricht, The Netherlands. at.dejong@maastrichtuniversity.nl
FAU - Dondorp, Wybo J
AU  - Dondorp WJ
FAU - Frints, Suzanna G M
AU  - Frints SG
FAU - de Die-Smulders, Christine E M
AU  - de Die-Smulders CE
FAU - de Wert, Guido M W R
AU  - de Wert GM
LA  - eng
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110818
PL  - England
TA  - Nat Rev Genet
JT  - Nature reviews. Genetics
JID - 100962779
SB  - IM
MH  - Abortion, Eugenic
MH  - Aneuploidy
MH  - Child
MH  - *Chromosome Aberrations
MH  - Ethics, Medical
MH  - Female
MH  - Genetic Association Studies/*methods
MH  - Genetic Testing
MH  - Humans
MH  - Infant, Newborn
MH  - Karyotyping
MH  - Neonatal Screening/*ethics
MH  - Patient Rights/ethics
MH  - Pregnancy
MH  - Prenatal Diagnosis/ethics/methods
MH  - Sequence Analysis, DNA
EDAT- 2011/08/19 06:00
MHDA- 2011/10/18 06:00
CRDT- 2011/08/19 06:00
PHST- 2011/08/19 06:00 [entrez]
PHST- 2011/08/19 06:00 [pubmed]
PHST- 2011/10/18 06:00 [medline]
AID - nrg3036 [pii]
AID - 10.1038/nrg3036 [doi]
PST - epublish
SO  - Nat Rev Genet. 2011 Aug 18;12(9):657-63. doi: 10.1038/nrg3036.


PMID- 21849749
OWN - NLM
STAT- MEDLINE
DCOM- 20120112
LR  - 20140730
IS  - 1875-9270 (Electronic)
IS  - 1051-9815 (Linking)
VI  - 40
IP  - 1
DP  - 2011
TI  - End-of-life healthcare decision-making: the intermediary role of the ethicist in 
      supporting family caregivers and health professionals.
PG  - 63-73
LID - 10.3233/WOR-2011-1207 [doi]
AB  - OBJECTIVE: Family support in end-of-life decision-making is critical, yet this
      issue receives little attention. The purpose of this research is to provide
      insight into how the clinical ethicist can effectively support family caregivers 
      when making end-of-life healthcare decisions. It further suggests how the
      clinical ethicist can provide support to other healthcare professionals who work 
      with family caregivers in making end-of-life healthcare decisions. PARTICIPANTS
      AND METHODS: Using a grounded theory approach, a theoretical sampling of 20
      family caregivers previously involved in end-of-life decision-making were
      interviewed. Semi-structured in-depth interviews were audiotaped, and
      transcribed. RESULTS: Interviews were analyzed using a constant comparative
      approach. The analysis resulted in the identification of three categories related
      to the experience of decision-making: the impact of healthcare decision-making on
      individual and family well-being, the effectiveness of healthcare professionals
      in supporting families, and the role of the ethicist. CONCLUSIONS: The results
      demonstrated the challenges that family members encounter when faced with
      end-of-life decision-making. The participants identified the importance of having
      access to a clinical ethicist who, with objectivity and specific training, can
      better meet the needs of family caregivers and improve the process of
      decision-making at the end-of-life.
FAU - MacDonald, Rosemary C
AU  - MacDonald RC
AD  - Sisters of St. Martha of Prince Edward Island, Mount St. Mary's, Charlottetown,
      PE, Canada.
FAU - Weeks, Lori E
AU  - Weeks LE
FAU - McInnis-Perry, Gloria
AU  - McInnis-Perry G
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Work
JT  - Work (Reading, Mass.)
JID - 9204382
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Caregivers
MH  - *Decision Making
MH  - *Ethicists
MH  - Female
MH  - *Health Personnel
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Middle Aged
MH  - *Professional Role
MH  - *Social Support
MH  - Terminal Care/*ethics
EDAT- 2011/08/19 06:00
MHDA- 2012/01/13 06:00
CRDT- 2011/08/19 06:00
PHST- 2011/08/19 06:00 [entrez]
PHST- 2011/08/19 06:00 [pubmed]
PHST- 2012/01/13 06:00 [medline]
AID - U836K9836L264062 [pii]
AID - 10.3233/WOR-2011-1207 [doi]
PST - ppublish
SO  - Work. 2011;40(1):63-73. doi: 10.3233/WOR-2011-1207.


PMID- 21848926
OWN - NLM
STAT- MEDLINE
DCOM- 20120507
LR  - 20220409
IS  - 1365-2648 (Electronic)
IS  - 0309-2402 (Linking)
VI  - 68
IP  - 2
DP  - 2012 Feb
TI  - Leading change: a three-dimensional model of nurse leaders' main tasks and roles 
      during a change process.
PG  - 423-33
LID - 10.1111/j.1365-2648.2011.05802.x [doi]
AB  - AIM: This paper is a report of a qualitative study which explored how nurse
      leaders described and understood their main tasks and roles during a change
      process. BACKGROUND: During a database search for literature, no actual research 
      that highlighted the main tasks and roles of nurse leaders during a change
      process was found. Earlier research has indicated the need for different
      leadership styles and the importance of strategies and values. METHOD: In-depth
      interviews with 17 nurse leaders took place in 2004. A
      phenomenological-hermeneutical approach was used for data analysis. RESULTS: The 
      findings resulted in a model of leading change in health care that focuses on
      good patient care and consists of three dimensions: leading relationships,
      leading processes and leading a culture. In addition to leading relationships and
      processes, nurse leaders, as role models, greatly impact caring culture and its
      inherent ethical behaviour, especially about the responsibility for achieving
      good patient care. Nurse leaders are also instrumental in leading ward culture.
      CONCLUSION: Nurse leaders need guidance and knowledge of what is expected of them
      during a structural change process. They play different roles by directing,
      guiding, motivating, supporting and communicating without losing their cultural
      ethos of caring and use various leadership styles to bring about actual change,
      which, in turn, requires learning so that the thought patterns, values and
      attitudes of personnel can be changed.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Salmela, Susanne
AU  - Salmela S
AD  - Department of Social Sciences, Abo Akademi University, Vaasa, Finland.
      susanne.salmela@vshp.fi
FAU - Eriksson, Katie
AU  - Eriksson K
FAU - Fagerstrom, Lisbeth
AU  - Fagerstrom L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110816
PL  - England
TA  - J Adv Nurs
JT  - Journal of advanced nursing
JID - 7609811
SB  - IM
CIN - J Adv Nurs. 2012 Feb;68(2):247
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Empathy
MH  - Female
MH  - Finland
MH  - Health Care Reform/organization & administration
MH  - Health Facility Merger/*organization & administration
MH  - Humans
MH  - Interprofessional Relations
MH  - *Leadership
MH  - Middle Aged
MH  - Models, Theoretical
MH  - *Nurse Administrators
MH  - *Nurse's Role
MH  - Nursing Administration Research
MH  - Organizational Culture
MH  - Organizational Innovation
MH  - Qualitative Research
MH  - Quality of Health Care
EDAT- 2011/08/19 06:00
MHDA- 2012/05/09 06:00
CRDT- 2011/08/19 06:00
PHST- 2011/08/19 06:00 [entrez]
PHST- 2011/08/19 06:00 [pubmed]
PHST- 2012/05/09 06:00 [medline]
AID - 10.1111/j.1365-2648.2011.05802.x [doi]
PST - ppublish
SO  - J Adv Nurs. 2012 Feb;68(2):423-33. doi: 10.1111/j.1365-2648.2011.05802.x. Epub
      2011 Aug 16.


PMID- 21848088
OWN - NLM
STAT- MEDLINE
DCOM- 20110923
LR  - 20211203
IS  - 0037-8046 (Print)
IS  - 0037-8046 (Linking)
VI  - 56
IP  - 3
DP  - 2011 Jul
TI  - Multiracial competence in social work: recommendations for culturally attuned
      work with multiracial people.
PG  - 235-45
AB  - According to the 2010 U.S. census, approximately 9 million individuals report
      multiracial identities. By the year 2050, as many as one in five Americans could 
      claim a multiracial background. Despite this population growth, a review of
      recent empirical and theoretical literature in social work suggests a
      disproportionate lack of attention to issues ofmultiraciality. Instead, social
      work practice models remain embedded in traditional societal discourses of race
      and culture that often exclude or marginalize the experiences of multiracial
      individuals and families.This article summarizes recommendations following the
      domains of awareness, knowledge, and skills in the NASW Standards for Cultural
      Competence in Social Work Practice to support culturally attuned social work
      practice with multiracial people. The authors argue that a culturally attuned
      practice approach--one that is inclusive of multiraciality--is not only timely,
      but also consistent with the profession's ethical obligation to provide
      culturally relevant services to all consumers and clients.
FAU - Jackson, Kelly E
AU  - Jackson KE
AD  - School of Social Work, College of Public Programs, Arizona State University,
      Phoenix, AZ 85004, USA. kelly.f.jackson@asu.edu
FAU - Samuels, Gina M
AU  - Samuels GM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Soc Work
JT  - Social work
JID - 2984852R
SB  - IM
MH  - *Cultural Competency
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Models, Theoretical
MH  - Racial Groups/*ethnology
MH  - *Social Work
MH  - United States
EDAT- 2011/08/19 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/08/19 06:00
PHST- 2011/08/19 06:00 [entrez]
PHST- 2011/08/19 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 10.1093/sw/56.3.235 [doi]
PST - ppublish
SO  - Soc Work. 2011 Jul;56(3):235-45. doi: 10.1093/sw/56.3.235.


PMID- 21846778
OWN - NLM
STAT- MEDLINE
DCOM- 20120820
LR  - 20211020
IS  - 1527-974X (Electronic)
IS  - 1067-5027 (Linking)
VI  - 19
IP  - 3
DP  - 2012 May-Jun
TI  - Search terms and a validated brief search filter to retrieve publications on
      health-related values in Medline: a word frequency analysis study.
PG  - 479-88
LID - 10.1136/amiajnl-2011-000243 [doi]
AB  - OBJECTIVE: Healthcare debates and policy developments are increasingly concerned 
      with a broad range of values-related areas. These include not only ethical,
      moral, religious, and other types of values 'proper', but also beliefs,
      preferences, experiences, choices, satisfaction, quality of life, etc. Research
      on such issues may be difficult to retrieve. This study used word frequency
      analysis to generate a broad pool of search terms and a brief filter to
      facilitate relevant searches in bibliographic databases. METHODS: Word frequency 
      analysis for 'values terms' was performed on citations on diabetes, obesity,
      dementia, and schizophrenia (Medline; 2004-2006; 4440 citations; 1,110,291
      words). Concordance(R) and SPSS 14.0 were used. Text words and MeSH terms of high
      frequency and precision were compiled into a search filter. It was validated on
      datasets of citations on dentistry and food hypersensitivity. RESULTS: 144 unique
      text words and 124 unique MeSH terms of moderate and high frequency (>/= 20) and 
      very high precision (>/= 90%) were identified. Of these, 19 text words and seven 
      MeSH terms were compiled into a 'brief values filter'. In the derivation dataset,
      it had a sensitivity of 76.8% and precision of 86.8%. In the validation datasets,
      its sensitivity and precision were, respectively, 70.1% and 63.6% (food
      hypersensitivity) and 47.1% and 82.6% (dentistry). CONCLUSIONS: This study
      provided a varied pool of search terms and a simple and highly effective tool for
      retrieving publications on health-related values. Further work is required to
      facilitate access to such research and enhance its chances of being translated
      into practice, policy, and service improvements.
FAU - Petrova, Mila
AU  - Petrova M
AD  - Egenis-ESRC Centre for Genomics in Society, University of Exeter, Exeter, UK.
      mp320@exeter.ac.uk
FAU - Sutcliffe, Paul
AU  - Sutcliffe P
FAU - Fulford, K W M Bill
AU  - Fulford KW
FAU - Dale, Jeremy
AU  - Dale J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110816
PL  - England
TA  - J Am Med Inform Assoc
JT  - Journal of the American Medical Informatics Association : JAMIA
JID - 9430800
SB  - IM
MH  - Data Mining
MH  - *Ethics, Medical
MH  - Humans
MH  - Information Storage and Retrieval/*methods
MH  - *MEDLINE
MH  - Medical Subject Headings
MH  - Sensitivity and Specificity
MH  - *Social Values
PMC - PMC3341778
EDAT- 2011/08/19 06:00
MHDA- 2012/08/21 06:00
CRDT- 2011/08/18 06:00
PHST- 2011/08/18 06:00 [entrez]
PHST- 2011/08/19 06:00 [pubmed]
PHST- 2012/08/21 06:00 [medline]
AID - amiajnl-2011-000243 [pii]
AID - 10.1136/amiajnl-2011-000243 [doi]
PST - ppublish
SO  - J Am Med Inform Assoc. 2012 May-Jun;19(3):479-88. doi:
      10.1136/amiajnl-2011-000243. Epub 2011 Aug 16.


PMID- 21846668
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20161020
IS  - 1471-1893 (Print)
IS  - 1471-1893 (Linking)
VI  - 38
IP  - 1
DP  - 2012 Jan
TI  - How do women feel about their cervical cytology samples being used for research?
PG  - 30-4
LID - 10.1136/jfprhc-2011-014319 [doi]
AB  - BACKGROUND AND METHODOLOGY: The introduction of liquid-based cytology (LBC) for
      cervical screening in the UK has enabled research into human papillomavirus as an
      adjunct to screening and provides potential opportunities for population-based
      research into women's health. The authors explored women's views on the use of
      remnant LBC samples for sexual and reproductive health research. A pilot study
      was conducted to assess the acceptability of collecting and storing remnant LBC
      specimens for future use in sexual and reproductive health research. Women
      attending a clinic for their routine smear test were recruited to the study.
      Semi-structured interviews were conducted with a subsample of the women to
      explore acceptability issues. RESULTS: Of women invited to participate (n=369),
      86% (n=316) consented to the storage and use of their remnant sample for
      research. Of these, 96% (n=304) consented to their sample being linked to
      reproductive health records. Women interviewed (n=23) were happy with the
      research process although unclear about what future research might be conducted
      on their specimen and what health records would be accessed. DISCUSSION AND
      CONCLUSION: As research becomes technically and ethically more complex the
      challenge remains to find the right balance between providing sufficient relevant
      information to ensure informed consent and allay participant's fears, while
      guarding against the inclusion of excessive detail. The introduction of LBC for
      cervical screening across the UK brings a new opportunity to integrate research
      studies within a national cervical screening programme. Our study suggests this
      is acceptable to women.
FAU - Coope, Caroline
AU  - Coope C
AD  - Research Department of Infection and Population Health, University College
      London, London, UK. caroline.coope@ucl.ac.uk
FAU - Rose, Karen
AU  - Rose K
FAU - Glasier, Anna
AU  - Glasier A
FAU - Stephenson, Judith
AU  - Stephenson J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110816
PL  - England
TA  - J Fam Plann Reprod Health Care
JT  - The journal of family planning and reproductive health care
JID - 101087687
SB  - IM
MH  - Adult
MH  - Biomedical Research/*methods
MH  - Cervix Uteri/*pathology
MH  - Cytodiagnosis/methods
MH  - Female
MH  - Humans
MH  - Interviews as Topic
MH  - Middle Aged
MH  - Pilot Projects
MH  - *Tissue Banks
MH  - Tissue and Organ Procurement/*statistics & numerical data
MH  - Vaginal Smears/*methods
EDAT- 2011/08/19 06:00
MHDA- 2012/09/21 06:00
CRDT- 2011/08/18 06:00
PHST- 2011/08/18 06:00 [entrez]
PHST- 2011/08/19 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
AID - jfprhc-2011-014319 [pii]
AID - 10.1136/jfprhc-2011-014319 [doi]
PST - ppublish
SO  - J Fam Plann Reprod Health Care. 2012 Jan;38(1):30-4. doi:
      10.1136/jfprhc-2011-014319. Epub 2011 Aug 16.


PMID- 21846598
OWN - NLM
STAT- MEDLINE
DCOM- 20120223
LR  - 20131121
IS  - 1558-2531 (Electronic)
IS  - 0018-9294 (Linking)
VI  - 58
IP  - 11
DP  - 2011 Nov
TI  - Bayesian population modeling of phase I dose escalation studies: Gaussian process
      versus parametric approaches.
PG  - 3156-64
LID - 10.1109/TBME.2011.2164614 [doi]
AB  - The early stages of the drug development process are often characterized by a
      limited number of subjects participating the study and a limited number of
      measurements per individual that can be collected, mainly due to technical,
      ethical, and cost reasons. The so-called dose escalation studies, performed
      during phase I, usually involve about 40 subjects or less, and feature
      observations at no more than three (rarely four or five) dose levels-per-subject.
      Depending on the complexity of the underlying pharmacokinetics, simple linear
      models or nonlinear ones (e.g., power, E(max) models) may be appropriate to
      describe the relationship between the metrics of systemic exposure to the drug
      (C(max), AUC) and the administered dose. However, in such data-poor scenarios,
      formulating models based on parametric descriptions is generally hard, and may
      easily result in model misspecification. Hence, nonparametric or "model-free"
      solutions, borrowed from the machine learning field, are deemed appealing. We
      resort to Gaussian process theory to work out Bayesian posterior expectations of 
      a population (a.k.a mixed-effects) regression problem, namely Population
      Smoothing Splines (PSS). We show that in seven experimental dose escalation
      studies, Population Smoothing Splines improve on three widely used parametric
      population methods. Superiority of the model-free technique is confirmed by a
      simulated benchmark: Population Smoothing Splines compare very favorably even
      with the true parametric model structure underlying the simulated data.
FAU - Russu, Alberto
AU  - Russu A
AD  - Department of Computer Engineering and Systems Science, University of Pavia,
      Pavia, Italy. alberto.russu@unipv.it
FAU - Poggesi, Italo
AU  - Poggesi I
FAU - Gomeni, Roberto
AU  - Gomeni R
FAU - De Nicolao, Giuseppe
AU  - De Nicolao G
LA  - eng
PT  - Journal Article
DEP - 20110815
PL  - United States
TA  - IEEE Trans Biomed Eng
JT  - IEEE transactions on bio-medical engineering
JID - 0012737
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - *Bayes Theorem
MH  - Clinical Trials, Phase I as Topic/*methods
MH  - Computer Simulation
MH  - *Drug-Related Side Effects and Adverse Reactions
MH  - Humans
MH  - *Models, Biological
MH  - *Models, Statistical
MH  - Pharmaceutical Preparations/*administration & dosage
EDAT- 2011/08/19 06:00
MHDA- 2012/02/24 06:00
CRDT- 2011/08/18 06:00
PHST- 2011/08/18 06:00 [entrez]
PHST- 2011/08/19 06:00 [pubmed]
PHST- 2012/02/24 06:00 [medline]
AID - 10.1109/TBME.2011.2164614 [doi]
PST - ppublish
SO  - IEEE Trans Biomed Eng. 2011 Nov;58(11):3156-64. doi: 10.1109/TBME.2011.2164614.
      Epub 2011 Aug 15.


PMID- 21846348
OWN - NLM
STAT- MEDLINE
DCOM- 20120223
LR  - 20211020
IS  - 1742-4755 (Electronic)
IS  - 1742-4755 (Linking)
VI  - 8
DP  - 2011 Aug 16
TI  - Trends in induced abortion among Nordic women aged 40-44 years.
PG  - 23
LID - 10.1186/1742-4755-8-23 [doi]
AB  - OBJECTIVES: Women aged 40-44 years in 2005 ought to have been subjected to much
      more influence on attitudes and knowledge on contraceptive methods during their
      fertile period than women who were in the same age span in 1975 when the abortion
      laws were introduced. MATERIAL: From official statistics, the rates of induced
      abortion and birth rates in women aged 40-44 years were collected for Sweden,
      Denmark, Norway and Finland for each five-year during the period 1975-2005.
      RESULTS: With the exception of Sweden all other studied Scandinavian countries
      have lowered their abortion rates since 1975 (p<0.001) and reduced the proportion
      of induced abortions in relation to birth rate (p<0.001). In 2005 these countries
      also had lower rates of induced abortion than Sweden in the age group 40-44 years
      (p<0.001). CONCLUSION: There is a significant change in rates of induced abortion
      in women aged 40-44 years in Finland, Norway, Denmark, and at status quo in
      Sweden. 40-44 years in Finland, Norway, Denmark, and at status quo in Sweden.
      This indicates that family planning programs works well in the Nordic countries. 
      The differences found may be assumed to possible diverging focus on attitudes or 
      ethical considerations.
FAU - Sydsjo, Adam
AU  - Sydsjo A
AD  - Division of Obstetrics and Gynecology, Department of Clinical and Experimental
      Medicine, Faculty of Health Sciences, Linkoping University, SE-581 83 Linkoping, 
      Sweden.
FAU - Josefsson, Ann
AU  - Josefsson A
FAU - Bladh, Marie
AU  - Bladh M
FAU - Sydsjo, Gunilla
AU  - Sydsjo G
LA  - eng
PT  - Journal Article
DEP - 20110816
PL  - England
TA  - Reprod Health
JT  - Reproductive health
JID - 101224380
SB  - IM
MH  - Abortion, Induced/statistics & numerical data/*trends
MH  - Adult
MH  - Birth Rate/trends
MH  - Female
MH  - Finland/epidemiology
MH  - Humans
MH  - Pregnancy
MH  - Scandinavian and Nordic Countries/epidemiology
PMC - PMC3168396
EDAT- 2011/08/19 06:00
MHDA- 2012/02/24 06:00
CRDT- 2011/08/18 06:00
PHST- 2011/05/09 00:00 [received]
PHST- 2011/08/16 00:00 [accepted]
PHST- 2011/08/18 06:00 [entrez]
PHST- 2011/08/19 06:00 [pubmed]
PHST- 2012/02/24 06:00 [medline]
AID - 1742-4755-8-23 [pii]
AID - 10.1186/1742-4755-8-23 [doi]
PST - epublish
SO  - Reprod Health. 2011 Aug 16;8:23. doi: 10.1186/1742-4755-8-23.


PMID- 21846200
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20211020
IS  - 1557-7422 (Electronic)
IS  - 1043-0342 (Linking)
VI  - 22
IP  - 11
DP  - 2011 Nov
TI  - Regulatory and ethical issues for phase I in utero gene transfer studies.
PG  - 1323-30
LID - 10.1089/hum.2011.062 [doi]
AB  - Clinical gene transfer research has involved adult and child subjects, and it is 
      expected that gene transfer in fetal subjects will occur in the future. Some
      genetic diseases have serious adverse effects on the fetus before birth, and
      there is hope that prenatal gene therapy could prevent such disease progression. 
      Research in animal models of prenatal gene transfer is actively being pursued.
      The prospect of human phase I in utero gene transfer studies raises important
      regulatory and ethical issues. One issue not previously addressed arises in
      applying U.S. research regulations to such studies. Specifically, current
      regulations state that research involving greater than minimal risk to the fetus 
      and no prospect of direct benefit to the fetus or pregnant woman is not
      permitted. Phase I studies will involve interventions such as needle insertions
      through the uterus, which carry risks to the fetus including spontaneous abortion
      and preterm birth. It is possible that these risks will be regarded as exceeding 
      minimal. Also, some regard the probability of therapeutic benefit in phase I
      studies to be so low that these studies do not satisfy the regulatory requirement
      that they "hold out the prospect of direct benefit" to subjects. On the basis of 
      these considerations, investigators and institutional review boards might
      reasonably conclude that some phase I in utero studies are not to be permitted.
      This paper identifies considerations that are relevant to such judgments and
      explores ethically acceptable ways in which phase I studies can be designed so
      that they are permitted by the regulations.
FAU - Strong, Carson
AU  - Strong C
AD  - Department of Medicine, College of Medicine, University of Tennessee Health
      Science Center, Memphis, TN 38163, USA. cstrong@uthsc.edu
LA  - eng
GR  - R03HG005225/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110923
PL  - United States
TA  - Hum Gene Ther
JT  - Human gene therapy
JID - 9008950
SB  - IM
MH  - Clinical Trials, Phase I as Topic/*ethics/*legislation & jurisprudence
MH  - Ethics Committees, Research/ethics/legislation & jurisprudence
MH  - Ethics, Medical
MH  - Female
MH  - Fetal Diseases/therapy
MH  - Fetus/pathology
MH  - Genetic Counseling
MH  - Genetic Therapy/*ethics/*legislation & jurisprudence
MH  - Humans
MH  - Pregnancy
MH  - Risk Assessment
PMC - PMC3225039
EDAT- 2011/08/19 06:00
MHDA- 2012/11/14 06:00
CRDT- 2011/08/18 06:00
PHST- 2011/08/18 06:00 [entrez]
PHST- 2011/08/19 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
AID - 10.1089/hum.2011.062 [doi]
PST - ppublish
SO  - Hum Gene Ther. 2011 Nov;22(11):1323-30. doi: 10.1089/hum.2011.062. Epub 2011 Sep 
      23.


PMID- 21845922
OWN - NLM
STAT- MEDLINE
DCOM- 20110906
LR  - 20220409
IS  - 0093-0334 (Print)
IS  - 0093-0334 (Linking)
VI  - 41
IP  - 4
DP  - 2011 Jul-Aug
TI  - Can research and care be ethically integrated?
PG  - 37-46
AB  - Medical ethics assumes a clear boundary between clinical research and clinical
      medicine: one produces knowledge for the benefit of future patients, while the
      other provides optimal care to individuals right now. It also assumes that the
      two cannot be integrated without sacrificing the needs of the current patient to 
      those of future patients. But integration could allow us to provide better care
      to everyone, now and in the future.
FAU - Largent, Emily A
AU  - Largent EA
AD  - Harvard University, USA.
FAU - Joffe, Steven
AU  - Joffe S
FAU - Miller, Franklin G
AU  - Miller FG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hastings Cent Rep
JT  - The Hastings Center report
JID - 0410447
SB  - IM
CIN - Hastings Cent Rep. 2012 May-Jun;42(3):7. PMID: 22670289
MH  - Biomedical Research/*ethics/*organization & administration
MH  - Clinical Trials as Topic/ethics/methods
MH  - Health Services Administration/*ethics
MH  - Human Experimentation/ethics
MH  - Humans
MH  - Philosophy, Medical
MH  - Risk Assessment
MH  - Social Justice/ethics
MH  - *Systems Integration
EDAT- 2011/08/19 06:00
MHDA- 2011/09/07 06:00
CRDT- 2011/08/18 06:00
PHST- 2011/08/18 06:00 [entrez]
PHST- 2011/08/19 06:00 [pubmed]
PHST- 2011/09/07 06:00 [medline]
AID - 10.1002/j.1552-146x.2011.tb00123.x [doi]
PST - ppublish
SO  - Hastings Cent Rep. 2011 Jul-Aug;41(4):37-46. doi:
      10.1002/j.1552-146x.2011.tb00123.x.


PMID- 21845917
OWN - NLM
STAT- MEDLINE
DCOM- 20110906
LR  - 20191112
IS  - 0093-0334 (Print)
IS  - 0093-0334 (Linking)
VI  - 41
IP  - 4
DP  - 2011 Jul-Aug
TI  - The ethics of synthetic biology: guiding principles for emerging technologies.
PG  - 17-22
FAU - Gutmann, Amy
AU  - Gutmann A
AD  - University of Pennsylvania, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Hastings Cent Rep
JT  - The Hastings Center report
JID - 0410447
SB  - IM
CIN - Hastings Cent Rep. 2014 Nov-Dec;44(6 Spec no.):S4-S26. PMID: 25418704
MH  - Biomedical Research/*ethics
MH  - Biomedical Technology/*ethics
MH  - Cooperative Behavior
MH  - Humans
MH  - Philosophy, Medical
MH  - Policy
MH  - Risk Assessment
MH  - Synthetic Biology/*ethics
EDAT- 2011/08/19 06:00
MHDA- 2011/09/07 06:00
CRDT- 2011/08/18 06:00
PHST- 2011/08/18 06:00 [entrez]
PHST- 2011/08/19 06:00 [pubmed]
PHST- 2011/09/07 06:00 [medline]
AID - 10.1002/j.1552-146x.2011.tb00118.x [doi]
PST - ppublish
SO  - Hastings Cent Rep. 2011 Jul-Aug;41(4):17-22. doi:
      10.1002/j.1552-146x.2011.tb00118.x.


PMID- 21845556
OWN - NLM
STAT- MEDLINE
DCOM- 20110901
LR  - 20111110
IS  - 0303-7339 (Print)
IS  - 0303-7339 (Linking)
VI  - 53
IP  - 8
DP  - 2011
TI  - [Assisted suicide in psychiatry; current situation and notes on a recent case].
PG  - 543-50
AB  - BACKGROUND: The Dutch legal system grants psychiatric patients the right to
      assisted suicide but imposes strict conditions. The matter, however, remains
      controversial. Many psychiatrists are reluctant to become involved in assisted
      suicide because they are not familiar with the procedure that has to be followed,
      nor are they clear about the precise meaning of 'acting responsibly'. AIM: To
      provide an overview of the procedure to be followed and of the criteria to be met
      when a psychiatrist is wondering whether to grant a patient's request for
      assistance with suicide. METHOD: We analyse the law, jurisprudence and medical
      ethics and the special problems that arise in the case of psychiatric patients.
      RESULTS: We describe the developments in law and psychiatric practice which have 
      led to greater recognition of the autonomy of the patient. The final decision
      depends on an assessment of the patient's competence and his ability to
      articulate his request clearly and on the hopelessness engendered by unbearable
      suffering. CONCLUSION: In the future there may be an increase in the number of
      cases of assisted suicide in psychiatry now that procedures and criteria have
      been established which are in accordance with the Dutch legal system.
FAU - de Boer, A P
AU  - de Boer AP
FAU - Oei, T I
AU  - Oei TI
LA  - dut
PT  - English Abstract
PT  - Journal Article
TT  - Hulp bij zelfdoding in de psychiatrie; stand van zaken en bespreking van een
      recente casus.
PL  - Netherlands
TA  - Tijdschr Psychiatr
JT  - Tijdschrift voor psychiatrie
JID - 0423731
SB  - IM
CIN - Tijdschr Psychiatr. 2011;53(8):551-3. PMID: 21845557
CIN - Tijdschr Psychiatr. 2011;53(10):783-4; author reply 788-9. PMID: 21989761
CIN - Tijdschr Psychiatr. 2011;53(10):784-5; author reply 789-90. PMID: 21989762
CIN - Tijdschr Psychiatr. 2011;53(10):785-6; author reply 788. PMID: 21989763
CIN - Tijdschr Psychiatr. 2011;53(10):786-7; author reply 787-8. PMID: 21989764
MH  - *Ethics, Medical
MH  - Humans
MH  - *Mental Competency
MH  - Netherlands
MH  - Personal Autonomy
MH  - Physician-Patient Relations
MH  - Practice Guidelines as Topic
MH  - Psychiatry/*standards
MH  - Suicide, Assisted/*legislation & jurisprudence/*psychology
EDAT- 2011/08/17 06:00
MHDA- 2011/09/02 06:00
CRDT- 2011/08/17 06:00
PHST- 2011/08/17 06:00 [entrez]
PHST- 2011/08/17 06:00 [pubmed]
PHST- 2011/09/02 06:00 [medline]
AID - TVPart_9182 [pii]
PST - ppublish
SO  - Tijdschr Psychiatr. 2011;53(8):543-50.


PMID- 21845491
OWN - NLM
STAT- MEDLINE
DCOM- 20120124
LR  - 20131121
IS  - 1573-6571 (Electronic)
IS  - 0022-4197 (Linking)
VI  - 50
IP  - 3
DP  - 2011 Sep
TI  - Gray matters: a deployed physician's perspective on combat medicine in Iraq.
PG  - 527-42
LID - 10.1007/s10943-011-9524-2 [doi]
AB  - A female physician who was serving as a first-year medicine resident in Manhattan
      in September 2001 writes this paper. It details her experience of signing up for 
      military service as a result of the September 11th attack on the United States.
      She lays out the surroundings, atmosphere, and reactions of those around her
      during the attack and details her own personal motivations for joining the
      military, her need to take control and help those in need heal while also trying 
      to heal herself. Grateful, yet haunted by her experience, she provides an
      intimate glimpse into her time serving as a combat physician at a trauma hospital
      in Balad, Iraq during the 2007 military surge. A trained geriatrician and
      palliative care physician she recounts the stories of several patients that have 
      forever shaped her life and explores the contradictions and ethical challenges
      she faced while caring for them ultimately struggling with the uncertainty of
      whether what she was truly doing was good for those she served or herself.
FAU - Cereste, Heather X
AU  - Cereste HX
AD  - Public Health Weill Cornell Medical College, New York, NY, USA.
      seahorse6_10@yahoo.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Relig Health
JT  - Journal of religion and health
JID - 2985199R
SB  - IM
MH  - Anecdotes as Topic
MH  - Female
MH  - Humans
MH  - *Iraq War, 2003-2011
MH  - *Military Medicine/ethics
MH  - Motivation
MH  - Physicians/*psychology
EDAT- 2011/08/17 06:00
MHDA- 2012/01/25 06:00
CRDT- 2011/08/17 06:00
PHST- 2011/08/17 06:00 [entrez]
PHST- 2011/08/17 06:00 [pubmed]
PHST- 2012/01/25 06:00 [medline]
AID - 10.1007/s10943-011-9524-2 [doi]
PST - ppublish
SO  - J Relig Health. 2011 Sep;50(3):527-42. doi: 10.1007/s10943-011-9524-2.


PMID- 21845286
OWN - NLM
STAT- MEDLINE
DCOM- 20120124
LR  - 20170410
IS  - 2511-705X (Electronic)
IS  - 0026-1270 (Linking)
VI  - 50
IP  - 4
DP  - 2011
TI  - A model-driven privacy compliance decision support for medical data sharing in
      Europe.
PG  - 326-36
LID - 10.3414/ME10-01-0075 [doi]
AB  - OBJECTIVES: Clinical practitioners and medical researchers often have to share
      health data with other colleagues across Europe. Privacy compliance in this
      context is very important but challenging. Automated privacy guidelines are a
      practical way of increasing users' awareness of privacy obligations and help
      eliminating unintentional breaches of privacy. In this paper we present an
      ontology-plus-rules based approach to privacy decision support for the sharing of
      patient data across European platforms. METHODS: We use ontologies to model the
      required domain and context information about data sharing and privacy
      requirements. In addition, we use a set of Semantic Web Rule Language rules to
      reason about legal privacy requirements that are applicable to a specific context
      of data disclosure. We make the complete set invocable through the use of a
      semantic web application acting as an interactive privacy guideline system can
      then invoke the full model in order to provide decision support. RESULTS: When
      asked, the system will generate privacy reports applicable to a specific case of 
      data disclosure described by the user. Also reports showing guidelines per Member
      State may be obtained. CONCLUSION: The advantage of this approach lies in the
      expressiveness and extensibility of the modelling and inference languages adopted
      and the ability they confer to reason with complex requirements interpreted from 
      high level regulations. However, the system cannot at this stage fully simulate
      the role of an ethics committee or review board.
FAU - Boussi Rahmouni, H
AU  - Boussi Rahmouni H
AD  - Bristol Institute of Technology, University of the West of England, Bristol BS16 
      1QY, United Kingdom. Hanene2.Rahmouni@uwe.ac.uk
FAU - Solomonides, T
AU  - Solomonides T
FAU - Casassa Mont, M
AU  - Casassa Mont M
FAU - Shiu, S
AU  - Shiu S
FAU - Rahmouni, M
AU  - Rahmouni M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110726
PL  - Germany
TA  - Methods Inf Med
JT  - Methods of information in medicine
JID - 0210453
SB  - IM
MH  - Databases, Factual
MH  - Decision Making
MH  - Decision Support Systems, Clinical/*legislation & jurisprudence
MH  - Europe
MH  - Humans
MH  - Information Dissemination/*legislation & jurisprudence/methods
MH  - Information Storage and Retrieval
MH  - Models, Statistical
MH  - Privacy/*legislation & jurisprudence
MH  - Software
EDAT- 2011/08/17 06:00
MHDA- 2012/01/25 06:00
CRDT- 2011/08/17 06:00
PHST- 2010/10/17 00:00 [received]
PHST- 2011/03/07 00:00 [accepted]
PHST- 2011/08/17 06:00 [entrez]
PHST- 2011/08/17 06:00 [pubmed]
PHST- 2012/01/25 06:00 [medline]
AID - 10-01-0075 [pii]
AID - 10.3414/ME10-01-0075 [doi]
PST - ppublish
SO  - Methods Inf Med. 2011;50(4):326-36. doi: 10.3414/ME10-01-0075. Epub 2011 Jul 26.


PMID- 21844896
OWN - NLM
STAT- MEDLINE
DCOM- 20111221
LR  - 20220316
IS  - 1759-4766 (Electronic)
IS  - 1759-4758 (Linking)
VI  - 7
IP  - 9
DP  - 2011 Aug 16
TI  - Management of pain in multiple sclerosis: a pharmacological approach.
PG  - 519-27
LID - 10.1038/nrneurol.2011.120 [doi]
AB  - About half of patients with multiple sclerosis (MS) report pain; treatment for
      pain alone accounts for nearly 30% of the total use of medications for the
      management of all MS-related symptoms. Patients with MS can experience more than 
      one type of pain simultaneously and at any point during the disease course, even 
      in newly or recently diagnosed cases. Pain in MS can be associated with other
      symptoms, including spasticity, fatigue and mood disorder. Pain sufferers
      experience disruption in daily life activities, work, mood, recreation and
      general enjoyment of life, and report low satisfaction with pain management. Many
      clinical features of pain are often unrecognized by clinicians and are difficult 
      for patients to describe. The majority of clinical evidence regarding treatment
      stems from small pilot and open-label studies; therefore, treatment of pain
      associated with MS is often based on anecdotal reports and clinicians'
      experience. The open-label design of the majority of studies, the unavailability 
      of large samples and the difficulty of performing placebo-controlled studies
      because of ethical considerations result in insufficient evidence to support or
      refute the effectiveness of pain medications. This Review presents available data
      regarding pharmacological approaches for addressing pain in MS and highlights the
      shortcomings in pain management research.
FAU - Solaro, Claudio
AU  - Solaro C
AD  - Department of Neurology, PA Micone Hospital, ASL3 Genovese, Via Oliva 22, Genoa, 
      16153, Italy. csolaro@libero.it
FAU - Uccelli, Michele Messmer
AU  - Uccelli MM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110816
PL  - England
TA  - Nat Rev Neurol
JT  - Nature reviews. Neurology
JID - 101500072
RN  - 0 (Analgesics)
RN  - 0 (Analgesics, Opioid)
SB  - IM
MH  - Analgesics/therapeutic use
MH  - Analgesics, Opioid/therapeutic use
MH  - Complementary Therapies
MH  - Fatigue/etiology/therapy
MH  - Headache/complications/therapy
MH  - Humans
MH  - Multiple Sclerosis/*complications/*therapy
MH  - Musculoskeletal Pain/complications/therapy
MH  - Neuralgia/etiology/therapy
MH  - Pain/*drug therapy/epidemiology/*etiology
MH  - *Pain Management
MH  - Quality of Life
MH  - Spasm/complications/therapy
MH  - Trigeminal Neuralgia/drug therapy/etiology
EDAT- 2011/08/17 06:00
MHDA- 2011/12/22 06:00
CRDT- 2011/08/17 06:00
PHST- 2011/08/17 06:00 [entrez]
PHST- 2011/08/17 06:00 [pubmed]
PHST- 2011/12/22 06:00 [medline]
AID - nrneurol.2011.120 [pii]
AID - 10.1038/nrneurol.2011.120 [doi]
PST - epublish
SO  - Nat Rev Neurol. 2011 Aug 16;7(9):519-27. doi: 10.1038/nrneurol.2011.120.


PMID- 21844552
OWN - NLM
STAT- MEDLINE
DCOM- 20111006
LR  - 20191210
IS  - 1539-3704 (Electronic)
IS  - 0003-4819 (Linking)
VI  - 155
IP  - 4
DP  - 2011 Aug 16
TI  - Ethics and the law: is there common ground on informed consent for disparities in
      hospital outcomes?
PG  - 260-4
LID - 10.7326/0003-4819-155-4-201108160-00010 [doi]
AB  - The association between procedure volume at institutions and outcomes of cancer
      surgeries has been widely published in the medical literature; discussed in the
      lay press; and, during the past 15 years, incorporated into quality improvement
      endeavors. In certain cases, institutional volume has become a proxy for quality.
      Despite the vast amount of retrospective data on this topic, physicians generally
      have been unsure how to approach the information and interpret it for their
      patients. Even more challenging to some physicians has been deciding whether the 
      data oblige them to either direct patients with cancer to high-volume centers for
      care or discuss the data with these patients as part of informed consent. An
      additional challenge is that physicians must understand laws related to these
      issues and that these laws are unclear. This article reviews the ethical
      arguments for including disparities in hospital outcomes as part of informed
      consent and examines whether legal precedent can shed light on this debate.
FAU - Housri, Nadine
AU  - Housri N
AD  - UMDNJ Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
FAU - Coombs, Mary
AU  - Coombs M
FAU - Orandi, Babak J
AU  - Orandi BJ
FAU - Pawlik, Timothy M
AU  - Pawlik TM
FAU - Koniaris, Leonidas G
AU  - Koniaris LG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ann Intern Med
JT  - Annals of internal medicine
JID - 0372351
SB  - IM
MH  - *Ethics, Medical
MH  - Hospitals/*standards/*statistics & numerical data
MH  - Humans
MH  - Informed Consent/*ethics/*legislation & jurisprudence
MH  - Neoplasms/surgery
MH  - Outcome Assessment, Health Care/*statistics & numerical data
MH  - Quality Indicators, Health Care
MH  - Treatment Outcome
MH  - Truth Disclosure/ethics
MH  - United States
EDAT- 2011/08/17 06:00
MHDA- 2011/10/07 06:00
CRDT- 2011/08/17 06:00
PHST- 2011/08/17 06:00 [entrez]
PHST- 2011/08/17 06:00 [pubmed]
PHST- 2011/10/07 06:00 [medline]
AID - 155/4/260 [pii]
AID - 10.7326/0003-4819-155-4-201108160-00010 [doi]
PST - ppublish
SO  - Ann Intern Med. 2011 Aug 16;155(4):260-4. doi:
      10.7326/0003-4819-155-4-201108160-00010.


PMID- 21844401
OWN - NLM
STAT- MEDLINE
DCOM- 20120228
LR  - 20111004
IS  - 1558-9129 (Electronic)
IS  - 0161-1461 (Linking)
VI  - 42
IP  - 4
DP  - 2011 Oct
TI  - Educational audiologists: their access, benefit, and collaborative assistance to 
      speech-language pathologists in schools.
PG  - 444-60
LID - 10.1044/0161-1461(2011/10-0011) [doi]
AB  - PURPOSE: The main goals of this study were to determine if school-based
      speech-language pathologists (SLPs) have access to the services of an audiologist
      and if those SLPs felt they obtained benefit from the audiologist's services.
      Additional goals included gathering information about SLPs' (a) understanding of 
      basic audiological concepts typical for a school setting, (b) added job
      responsibilities brought about by lack of access to an audiologist, and (c)
      collaboration with audiologists. METHOD: A 36-item survey was e-mailed to 1,000
      SLPs listed with the American Speech-Language-Hearing Association as being
      employed in schools. Two-hundred and nine respondents from 42 states returned the
      survey. RESULTS: Seventy-six percent of the responding SLPs had access at some
      time to an audiologist, with 88% of them believing they received benefit from the
      services provided by that audiologist, primarily in the areas of hearing
      screenings and in-services. Thirty-eight SLPs (58%) who did not have access to an
      audiologist reported having additional job responsibilities. CONCLUSION: Many
      school-based SLPs believed they received benefit from an audiologist when they
      had access to one. Collaboration between these professionals was strong, yet
      findings indicate that audiologists could improve their collaborative efforts
      with SLPs and assist them in working within their scope of practice and
      maintaining their ethical standards.
FAU - Richburg, Cynthia McCormick
AU  - Richburg CM
AD  - Indiana University of Pennsylvania, Indiana, PA, USA. cynthia.richburg@iup.edu
FAU - Knickelbein, Becky A
AU  - Knickelbein BA
LA  - eng
PT  - Journal Article
DEP - 20110815
PL  - United States
TA  - Lang Speech Hear Serv Sch
JT  - Language, speech, and hearing services in schools
JID - 0323431
SB  - IM
MH  - Adult
MH  - *Audiology
MH  - Child
MH  - *Cooperative Behavior
MH  - Data Collection
MH  - Deafness/*rehabilitation
MH  - Female
MH  - *Health Services Accessibility
MH  - Health Services Needs and Demand
MH  - Health Services Research
MH  - Hearing Aids
MH  - Humans
MH  - *Interdisciplinary Communication
MH  - Job Description
MH  - Language Development Disorders/*rehabilitation
MH  - Male
MH  - Referral and Consultation
MH  - *School Health Services
MH  - *Speech-Language Pathology
MH  - Treatment Outcome
MH  - United States
MH  - Workload
EDAT- 2011/08/17 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/08/17 06:00
PHST- 2011/08/17 06:00 [entrez]
PHST- 2011/08/17 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - 0161-1461_2011_10-0011 [pii]
AID - 10.1044/0161-1461(2011/10-0011) [doi]
PST - ppublish
SO  - Lang Speech Hear Serv Sch. 2011 Oct;42(4):444-60. doi:
      10.1044/0161-1461(2011/10-0011). Epub 2011 Aug 15.


PMID- 21844286
OWN - NLM
STAT- MEDLINE
DCOM- 20120508
LR  - 20111130
IS  - 1049-7323 (Print)
IS  - 1049-7323 (Linking)
VI  - 21
IP  - 12
DP  - 2011 Dec
TI  - Overcoming barriers to the recruitment of nurses as participants in health care
      research.
PG  - 1705-18
LID - 10.1177/1049732311417727 [doi]
AB  - Adequate participant recruitment is critical for the successful execution of
      research studies involving human subjects. Participant recruitment can be
      particularly challenging when the intended study participants are health care
      providers as opposed to patients. Discussions of the challenges and successful
      strategies associated with provider recruitment are limited, particularly
      regarding providers other than physicians and settings outside of primary care.
      Using a case study format, we present our experiences recruiting inpatient nurses
      into a study which involved focus group methodology at a United States Veterans
      Health Administration facility. We describe the initial logistical and ethical
      issues involved, various challenges we encountered, and five successful action
      strategies used during a second recruitment wave addressing logistical issues;
      on-site recruitment; increased scheduling flexibility and peer-to-peer
      recruitment; attention to the sensitive nature of the research topic; and
      increased involvement of stakeholders. In conclusion, we advocate for multimodal 
      recruitment strategies that facilitate ongoing investigator-clinician
      partnerships.
FAU - Broyles, Lauren Matukaitis
AU  - Broyles LM
AD  - Center for Health Equity Research and Promotion, Veterans Affairs Pittsburgh
      Healthcare System, Pittsburgh, Pennsylvania 15206, USA. Lauren.Broyles@va.gov
FAU - Rodriguez, Keri L
AU  - Rodriguez KL
FAU - Price, Patrice A
AU  - Price PA
FAU - Bayliss, Nichole K
AU  - Bayliss NK
FAU - Sevick, Mary Ann
AU  - Sevick MA
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20110815
PL  - United States
TA  - Qual Health Res
JT  - Qualitative health research
JID - 9202144
MH  - Adult
MH  - Alcoholism/*nursing/psychology/rehabilitation
MH  - Female
MH  - Focus Groups
MH  - Health Services Research/ethics/methods
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nurses/*psychology
MH  - Nursing Research/ethics/*methods
MH  - Research Subjects/*psychology
MH  - United States
MH  - United States Department of Veterans Affairs
EDAT- 2011/08/17 06:00
MHDA- 2012/05/09 06:00
CRDT- 2011/08/17 06:00
PHST- 2011/08/17 06:00 [entrez]
PHST- 2011/08/17 06:00 [pubmed]
PHST- 2012/05/09 06:00 [medline]
AID - 1049732311417727 [pii]
AID - 10.1177/1049732311417727 [doi]
PST - ppublish
SO  - Qual Health Res. 2011 Dec;21(12):1705-18. doi: 10.1177/1049732311417727. Epub
      2011 Aug 15.


PMID- 21844278
OWN - NLM
STAT- MEDLINE
DCOM- 20111020
LR  - 20200314
IS  - 0032-5791 (Print)
IS  - 0032-5791 (Linking)
VI  - 90
IP  - 9
DP  - 2011 Sep
TI  - Values and public acceptability dimensions of sustainable egg production.
PG  - 2097-109
LID - 10.3382/ps.2010-0138 [doi]
AB  - The attributes of egg production that elicit values-based responses include the
      price and availability of eggs, environmental impacts, food safety or health
      concerns, and animal welfare. Different social groups have distinct interests
      regarding the sustainability of egg production that reflect these diverse values.
      Current scientifically based knowledge about how values and attitudes in these
      groups can be characterized is uneven and must be derived from studies conducted 
      at varying times and using incomplete study methods. In general, some producer
      and consumer interests are translated through markets and are mediated by market 
      mechanisms, whereas others are poorly reflected by economic behavior. An array of
      survey and focus group research has been performed to elicit consumer and
      activist beliefs about performance goals they would expect from an egg production
      system. These studies provide evidence that consumers' market behavior may be at 
      odds with their ethical and political beliefs about performance goals.
FAU - Thompson, P B
AU  - Thompson PB
AD  - Department of Philosophy, Michigan State University, East Lansing, MI 48824, USA.
      thomp649@msu.edu
FAU - Appleby, M
AU  - Appleby M
FAU - Busch, L
AU  - Busch L
FAU - Kalof, L
AU  - Kalof L
FAU - Miele, M
AU  - Miele M
FAU - Norwood, B F
AU  - Norwood BF
FAU - Pajor, E
AU  - Pajor E
LA  - eng
PT  - Journal Article
PL  - England
TA  - Poult Sci
JT  - Poultry science
JID - 0401150
SB  - IM
MH  - Animal Husbandry/*methods
MH  - Animal Welfare/standards
MH  - Animals
MH  - *Chickens
MH  - Conservation of Natural Resources/*methods
MH  - *Consumer Behavior
MH  - Eggs/*standards
MH  - Female
MH  - Social Responsibility
EDAT- 2011/08/17 06:00
MHDA- 2011/10/21 06:00
CRDT- 2011/08/17 06:00
PHST- 2011/08/17 06:00 [entrez]
PHST- 2011/08/17 06:00 [pubmed]
PHST- 2011/10/21 06:00 [medline]
AID - S0032-5791(19)30746-1 [pii]
AID - 10.3382/ps.2010-0138 [doi]
PST - ppublish
SO  - Poult Sci. 2011 Sep;90(9):2097-109. doi: 10.3382/ps.2010-0138.


PMID- 21844246
OWN - NLM
STAT- MEDLINE
DCOM- 20120207
LR  - 20211203
IS  - 1552-7832 (Electronic)
IS  - 1043-6596 (Linking)
VI  - 22
IP  - 4
DP  - 2011 Oct
TI  - Cultural safety as an ethic of care: a praxiological process.
PG  - 342-9
LID - 10.1177/1043659611414139 [doi]
AB  - New writings broadening the construct of cultural safety, a construct initiated
      in Aotearoa New Zealand, are beginning to appear in the literature. Therefore, it
      is considered timely to integrate these writings and advance the construct into a
      new theoretical model. The new model reconfigures the constructs of cultural
      safety and cultural competence as an ethic of care informed by a postmodern
      perspective. Central to the new model are three interwoven, co-occurring
      components: an ethic of care, which unfolds within a praxiological process shaped
      by the context. Context is expanded through identifying the three concepts of
      relationality, generic competence, and collectivity, which are integral to each
      client-nurse encounter. The competence associated with cultural safety as an
      ethic of care is always in the process of development. Clients and nurses engage 
      in a dialogue to establish the level of cultural safety achieved at given points 
      in a care trajectory.
FAU - McEldowney, Rose
AU  - McEldowney R
AD  - Charles Darwin University, Darwin, Australia.
FAU - Connor, Margaret J
AU  - Connor MJ
LA  - eng
PT  - Journal Article
DEP - 20110815
PL  - United States
TA  - J Transcult Nurs
JT  - Journal of transcultural nursing : official journal of the Transcultural Nursing 
      Society
JID - 9001407
MH  - *Cultural Competency
MH  - Humans
MH  - *Native Hawaiian or Other Pacific Islander
MH  - New Zealand
MH  - *Nurse-Patient Relations
MH  - Nursing Care/ethics/*standards
MH  - *Patient Safety
EDAT- 2011/08/17 06:00
MHDA- 2012/02/09 06:00
CRDT- 2011/08/17 06:00
PHST- 2011/08/17 06:00 [entrez]
PHST- 2011/08/17 06:00 [pubmed]
PHST- 2012/02/09 06:00 [medline]
AID - 1043659611414139 [pii]
AID - 10.1177/1043659611414139 [doi]
PST - ppublish
SO  - J Transcult Nurs. 2011 Oct;22(4):342-9. doi: 10.1177/1043659611414139. Epub 2011 
      Aug 15.


PMID- 21843429
OWN - NLM
STAT- MEDLINE
DCOM- 20111223
LR  - 20211020
IS  - 1545-1151 (Electronic)
IS  - 1545-1151 (Linking)
VI  - 8
IP  - 5
DP  - 2011 Sep
TI  - Ethical family interventions for childhood obesity.
PG  - A99
FAU - Perryman, Mandy L
AU  - Perryman ML
AD  - Lynchburg College, 1501 Lakeside Dr, Lynchburg, VA 24501-3199, USA.
      perryman@lynchburg.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110815
PL  - United States
TA  - Prev Chronic Dis
JT  - Preventing chronic disease
JID - 101205018
SB  - IM
MH  - *Bioethical Issues
MH  - Child
MH  - Child Abuse
MH  - Child Behavior
MH  - Decision Making
MH  - Diet, Reducing
MH  - Health Policy
MH  - Humans
MH  - Obesity/*prevention & control/psychology
MH  - *Parents
PMC - PMC3181199
EDAT- 2011/08/17 06:00
MHDA- 2011/12/24 06:00
CRDT- 2011/08/17 06:00
PHST- 2011/08/17 06:00 [entrez]
PHST- 2011/08/17 06:00 [pubmed]
PHST- 2011/12/24 06:00 [medline]
AID - A99 [pii]
PST - ppublish
SO  - Prev Chronic Dis. 2011 Sep;8(5):A99. Epub 2011 Aug 15.


PMID- 21843428
OWN - NLM
STAT- MEDLINE
DCOM- 20111223
LR  - 20220129
IS  - 1545-1151 (Electronic)
IS  - 1545-1151 (Linking)
VI  - 8
IP  - 5
DP  - 2011 Sep
TI  - The ethical basis for promoting nutritional health in public schools in the
      United States.
PG  - A98
AB  - Schools may have an ethical obligation to act in response to the precipitous
      increase in the incidence of obesity among children. Using a bioethics framework,
      we present a rationale for school programs to improve the nutritional quality of 
      students' diets. Because children are required to spend half their waking hours
      in school and because they consume a substantial portion of their daily food
      there, school is a logical focus for efforts to encourage healthy dietary
      behaviors to prevent obesity and its consequent individual and collective costs. 
      We suggest that beyond strategic considerations, the concept of the common good
      justifies actions that may appear to conflict with freedom of choice of children,
      parents, and school staff, or with the interests of food and beverage companies.
FAU - Crawford, Patricia B
AU  - Crawford PB
AD  - School of Public Health, University of California, Berkeley, CA 94720-3104, USA. 
      crawford@berkeley.edu
FAU - Gosliner, Wendi
AU  - Gosliner W
FAU - Kayman, Harvey
AU  - Kayman H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110815
PL  - United States
TA  - Prev Chronic Dis
JT  - Preventing chronic disease
JID - 101205018
SB  - IM
MH  - Child
MH  - Child Behavior
MH  - Child Nutritional Physiological Phenomena
MH  - Epidemics
MH  - Health Knowledge, Attitudes, Practice
MH  - Health Promotion/*ethics
MH  - Human Rights
MH  - Humans
MH  - Legislation, Food
MH  - Obesity/epidemiology/prevention & control
MH  - *Principle-Based Ethics
MH  - Schools/*ethics
MH  - United States/epidemiology
PMC - PMC3181198
EDAT- 2011/08/17 06:00
MHDA- 2011/12/24 06:00
CRDT- 2011/08/17 06:00
PHST- 2011/08/17 06:00 [entrez]
PHST- 2011/08/17 06:00 [pubmed]
PHST- 2011/12/24 06:00 [medline]
AID - A98 [pii]
PST - ppublish
SO  - Prev Chronic Dis. 2011 Sep;8(5):A98. Epub 2011 Aug 15.


PMID- 21843427
OWN - NLM
STAT- MEDLINE
DCOM- 20111223
LR  - 20220201
IS  - 1545-1151 (Electronic)
IS  - 1545-1151 (Linking)
VI  - 8
IP  - 5
DP  - 2011 Sep
TI  - A question of competing rights, priorities, and principles: a postscript to the
      Robert Wood Johnson Foundation symposium on the ethics of childhood obesity
      policy.
PG  - A97
FAU - Kumanyika, Shiriki K
AU  - Kumanyika SK
LA  - eng
PT  - Editorial
PT  - Introductory Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110815
PL  - United States
TA  - Prev Chronic Dis
JT  - Preventing chronic disease
JID - 101205018
SB  - IM
MH  - Advertising/legislation & jurisprudence
MH  - *Bioethical Issues
MH  - Child
MH  - Food/standards
MH  - Food Industry/legislation & jurisprudence
MH  - Health Policy/*legislation & jurisprudence
MH  - Human Rights/*legislation & jurisprudence/standards
MH  - Humans
MH  - National Academies of Science, Engineering, and Medicine, U.S., Health and
      Medicine Division
MH  - Obesity/*epidemiology/*prevention & control
MH  - United States/epidemiology
PMC - PMC3181197
EDAT- 2011/08/17 06:00
MHDA- 2011/12/24 06:00
CRDT- 2011/08/17 06:00
PHST- 2011/08/17 06:00 [entrez]
PHST- 2011/08/17 06:00 [pubmed]
PHST- 2011/12/24 06:00 [medline]
AID - A97 [pii]
PST - ppublish
SO  - Prev Chronic Dis. 2011 Sep;8(5):A97. Epub 2011 Aug 15.


PMID- 21843425
OWN - NLM
STAT- MEDLINE
DCOM- 20111223
LR  - 20211203
IS  - 1545-1151 (Electronic)
IS  - 1545-1151 (Linking)
VI  - 8
IP  - 5
DP  - 2011 Sep
TI  - Children with special health care needs: acknowledging the dilemma of difference 
      in policy responses to obesity.
PG  - A95
AB  - Children with special health care needs (SHCN) account for part of the increasing
      prevalence of childhood obesity in the general population and can face an
      elevated risk for obesity. The federal government, in partnership with states,
      has assumed the role of steward for this vulnerable population and supports a
      network of services designed to promote their health through increased access to 
      quality health services. Addressing obesity-related health risks among children
      with SHCN requires policies that support family- and community-based initiatives 
      in addition to health services. We discuss the ethics of child obesity policy
      from the perspective of children with SHCN and their families, and identify
      salient issues to optimize benefits for children and families. We refer to the
      dilemma of difference to identify policy concerns that are specific to children
      with SHCN and ethically may require different approaches. Determining the
      appropriate mix of inclusive and special obesity prevention initiatives for
      children with SHCN and identifying approaches to ensure their full participation 
      in community-based obesity prevention activities present challenges. Children
      with SHCN from low-income and minority communities are particularly vulnerable
      and warrant special attention.
FAU - Minihan, Paula M
AU  - Minihan PM
AD  - Department of Public Health and Community Medicine, Tufts University School of
      Medicine, 136 Harrison Ave, Boston, MA 02111, USA. paula.minihan@tufts.edu
FAU - Must, Aviva
AU  - Must A
FAU - Anderson, Betsy
AU  - Anderson B
FAU - Popper, Barbara
AU  - Popper B
FAU - Dworetzky, Beth
AU  - Dworetzky B
LA  - eng
GR  - P30 DK046200/DK/NIDDK NIH HHS/United States
PT  - Journal Article
DEP - 20110815
PL  - United States
TA  - Prev Chronic Dis
JT  - Preventing chronic disease
JID - 101205018
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child Health Services
MH  - Child, Preschool
MH  - Disabled Children/*statistics & numerical data
MH  - Ethnicity
MH  - Health Policy/*legislation & jurisprudence
MH  - Humans
MH  - Infant
MH  - Obesity/*epidemiology/*prevention & control
MH  - Racial Groups
MH  - Risk Factors
MH  - Socioeconomic Factors
MH  - United States/epidemiology
PMC - PMC3181195
EDAT- 2011/08/17 06:00
MHDA- 2011/12/24 06:00
CRDT- 2011/08/17 06:00
PHST- 2011/08/17 06:00 [entrez]
PHST- 2011/08/17 06:00 [pubmed]
PHST- 2011/12/24 06:00 [medline]
AID - A95 [pii]
PST - ppublish
SO  - Prev Chronic Dis. 2011 Sep;8(5):A95. Epub 2011 Aug 15.


PMID- 21843423
OWN - NLM
STAT- MEDLINE
DCOM- 20111223
LR  - 20220128
IS  - 1545-1151 (Electronic)
IS  - 1545-1151 (Linking)
VI  - 8
IP  - 5
DP  - 2011 Sep
TI  - Childhood obesity: a framework for policy approaches and ethical considerations.
PG  - A93
AB  - Although obesity rates among US children have increased during the past 3
      decades, effective public policies have been limited, and the quest for workable 
      solutions raises ethical questions. To address these concerns, in 2010, the
      Robert Wood Johnson Foundation convened an expert panel to consider approaches to
      the ethics problems related to interventions for childhood obesity. On the basis 
      of recommendations from the expert panel, we propose frameworks for policy
      approaches and ethical aspects of interventions and evaluation. We present these 
      frameworks in the context of other papers in this collection and make
      recommendations for public health practice.
FAU - Kersh, Rogan
AU  - Kersh R
AD  - New York University Wagner School, New York, New York, USA.
FAU - Stroup, Donna F
AU  - Stroup DF
FAU - Taylor, Wendell C
AU  - Taylor WC
LA  - eng
PT  - Journal Article
DEP - 20110815
PL  - United States
TA  - Prev Chronic Dis
JT  - Preventing chronic disease
JID - 101205018
SB  - IM
MH  - Beverages/economics
MH  - Bioethical Issues/*legislation & jurisprudence
MH  - Child
MH  - Food
MH  - Food Labeling/legislation & jurisprudence
MH  - Health Policy/*legislation & jurisprudence
MH  - Humans
MH  - Obesity/*epidemiology/*prevention & control
MH  - Public Health/*ethics/*legislation & jurisprudence
MH  - Taxes
MH  - United States/epidemiology
PMC - PMC3181193
EDAT- 2011/08/17 06:00
MHDA- 2011/12/24 06:00
CRDT- 2011/08/17 06:00
PHST- 2011/08/17 06:00 [entrez]
PHST- 2011/08/17 06:00 [pubmed]
PHST- 2011/12/24 06:00 [medline]
AID - A93 [pii]
PST - ppublish
SO  - Prev Chronic Dis. 2011 Sep;8(5):A93. Epub 2011 Aug 15.


PMID- 21843421
OWN - NLM
STAT- MEDLINE
DCOM- 20111223
LR  - 20211203
IS  - 1545-1151 (Electronic)
IS  - 1545-1151 (Linking)
VI  - 8
IP  - 5
DP  - 2011 Sep
TI  - Ethical concerns regarding interventions to prevent and control childhood
      obesity.
PG  - A91
FAU - Govea, John
AU  - Govea J
AD  - Robert Wood Johnson Foundation, Rt 1 and College Road East, PO Box 2316,
      Princeton, NJ 08543, USA. jgovea@rwjf.org
LA  - eng
PT  - Introductory Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110815
PL  - United States
TA  - Prev Chronic Dis
JT  - Preventing chronic disease
JID - 101205018
SB  - IM
MH  - Advertising/legislation & jurisprudence
MH  - Beverages/economics
MH  - Child
MH  - Child Welfare/*ethics
MH  - Ethnicity
MH  - Food/economics
MH  - Food Industry/*legislation & jurisprudence
MH  - Humans
MH  - Legislation as Topic
MH  - Motor Activity
MH  - Nutrition Surveys/statistics & numerical data
MH  - Obesity/*epidemiology/*prevention & control
MH  - Public Health/*legislation & jurisprudence
MH  - Racial Groups
MH  - Schools
MH  - United States/epidemiology
PMC - PMC3181191
EDAT- 2011/08/17 06:00
MHDA- 2011/12/24 06:00
CRDT- 2011/08/17 06:00
PHST- 2011/08/17 06:00 [entrez]
PHST- 2011/08/17 06:00 [pubmed]
PHST- 2011/12/24 06:00 [medline]
AID - A91 [pii]
PST - ppublish
SO  - Prev Chronic Dis. 2011 Sep;8(5):A91. Epub 2011 Aug 15.


PMID- 21843403
OWN - NLM
STAT- MEDLINE
DCOM- 20111223
LR  - 20220129
IS  - 1545-1151 (Electronic)
IS  - 1545-1151 (Linking)
VI  - 8
IP  - 5
DP  - 2011 Sep
TI  - Public policy versus individual rights and responsibility: an economist's
      perspective.
PG  - A100
AB  - Interventions to reduce childhood obesity entail ethical considerations. Although
      a rationale exists for government to intervene in a way that limits individual
      rights while protecting the public's health, a clear economic rationale also
      exists. The markets for goods and services that contribute to obesity are
      characterized by multiple failures that create an economic rationale for
      government to intervene (eg, consumers' lack of accurate information regarding
      obesogenic foods and beverages). If effective public policies for reducing
      obesity and its consequences are to be developed and implemented, individual
      rights and government interests must be balanced.
FAU - Chaloupka, Frank J
AU  - Chaloupka FJ
AD  - University of Illinois, 444 Westside Research Office Bldg, 1747 West Roosevelt
      Rd, Chicago, IL 60608, USA. fjc@uic.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110815
PL  - United States
TA  - Prev Chronic Dis
JT  - Preventing chronic disease
JID - 101205018
SB  - IM
MH  - Advertising/economics/ethics
MH  - Beverages/economics
MH  - *Bioethical Issues
MH  - Child
MH  - Food/economics
MH  - Human Rights
MH  - Humans
MH  - Obesity/*prevention & control
MH  - Public Policy/*economics/*legislation & jurisprudence
MH  - Taxes
PMC - PMC3181174
EDAT- 2011/08/17 06:00
MHDA- 2011/12/24 06:00
CRDT- 2011/08/17 06:00
PHST- 2011/08/17 06:00 [entrez]
PHST- 2011/08/17 06:00 [pubmed]
PHST- 2011/12/24 06:00 [medline]
AID - A100 [pii]
PST - ppublish
SO  - Prev Chronic Dis. 2011 Sep;8(5):A100. Epub 2011 Aug 15.


PMID- 21843388
OWN - NLM
STAT- MEDLINE
DCOM- 20111027
LR  - 20181201
IS  - 1469-2147 (Electronic)
IS  - 0963-1801 (Linking)
VI  - 20
IP  - 4
DP  - 2011 Oct
TI  - Ethical endgames: broad consent for narrow interests; open consent for closed
      minds.
PG  - 572-83
LID - 10.1017/S0963180111000314 [doi]
FAU - Karlsen, Jan Reinert
AU  - Karlsen JR
FAU - Solbakk, Jan Helge
AU  - Solbakk JH
FAU - Holm, Soren
AU  - Holm S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Camb Q Healthc Ethics
JT  - Cambridge quarterly of healthcare ethics : CQ : the international journal of
      healthcare ethics committees
JID - 9208482
SB  - IM
MH  - *Databases, Genetic/ethics/statistics & numerical data/trends
MH  - Ethics, Research
MH  - Genetic Research/*ethics
MH  - Humans
MH  - Information Dissemination/ethics
MH  - *Informed Consent/ethics
EDAT- 2011/08/17 06:00
MHDA- 2011/10/28 06:00
CRDT- 2011/08/17 06:00
PHST- 2011/08/17 06:00 [entrez]
PHST- 2011/08/17 06:00 [pubmed]
PHST- 2011/10/28 06:00 [medline]
AID - S0963180111000314 [pii]
AID - 10.1017/S0963180111000314 [doi]
PST - ppublish
SO  - Camb Q Healthc Ethics. 2011 Oct;20(4):572-83. doi: 10.1017/S0963180111000314.


PMID- 21843384
OWN - NLM
STAT- MEDLINE
DCOM- 20111027
LR  - 20110816
IS  - 1469-2147 (Electronic)
IS  - 0963-1801 (Linking)
VI  - 20
IP  - 4
DP  - 2011 Oct
TI  - Changing ethical frameworks: from individual rights to the common good?
PG  - 533-45
LID - 10.1017/S0963180111000272 [doi]
FAU - Sutrop, Margit
AU  - Sutrop M
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - Camb Q Healthc Ethics
JT  - Cambridge quarterly of healthcare ethics : CQ : the international journal of
      healthcare ethics committees
JID - 9208482
SB  - IM
MH  - Confidentiality
MH  - *Databases, Genetic/ethics/standards/trends
MH  - *Electronic Health Records/ethics/standards/trends
MH  - Ethical Theory/history
MH  - Greek World
MH  - History, Ancient
MH  - *Human Rights
MH  - Humans
MH  - Information Dissemination/ethics
MH  - Informed Consent/*ethics
MH  - *Personal Autonomy
MH  - *Social Justice/history
MH  - Virtues
EDAT- 2011/08/17 06:00
MHDA- 2011/10/28 06:00
CRDT- 2011/08/17 06:00
PHST- 2011/08/17 06:00 [entrez]
PHST- 2011/08/17 06:00 [pubmed]
PHST- 2011/10/28 06:00 [medline]
AID - S0963180111000272 [pii]
AID - 10.1017/S0963180111000272 [doi]
PST - ppublish
SO  - Camb Q Healthc Ethics. 2011 Oct;20(4):533-45. doi: 10.1017/S0963180111000272.


PMID- 21843383
OWN - NLM
STAT- MEDLINE
DCOM- 20111027
LR  - 20191210
IS  - 1469-2147 (Electronic)
IS  - 0963-1801 (Linking)
VI  - 20
IP  - 4
DP  - 2011 Oct
TI  - Limits of autonomy in biomedical ethics?: conceptual clarifications.
PG  - 524-32
LID - 10.1017/S0963180111000260 [doi]
FAU - Rehbock, Theda
AU  - Rehbock T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Camb Q Healthc Ethics
JT  - Cambridge quarterly of healthcare ethics : CQ : the international journal of
      healthcare ethics committees
JID - 9208482
SB  - IM
MH  - Altruism
MH  - *Beneficence
MH  - Biomedical Research/ethics
MH  - Coercion
MH  - Concept Formation
MH  - Conflict of Interest
MH  - *Conflict, Psychological
MH  - Ethical Theory
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Informed Consent/*ethics/standards
MH  - *Moral Obligations
MH  - Paternalism
MH  - *Personal Autonomy
MH  - *Social Justice
MH  - Tissue and Organ Procurement/ethics
MH  - Volition
EDAT- 2011/08/17 06:00
MHDA- 2011/10/28 06:00
CRDT- 2011/08/17 06:00
PHST- 2011/08/17 06:00 [entrez]
PHST- 2011/08/17 06:00 [pubmed]
PHST- 2011/10/28 06:00 [medline]
AID - S0963180111000260 [pii]
AID - 10.1017/S0963180111000260 [doi]
PST - ppublish
SO  - Camb Q Healthc Ethics. 2011 Oct;20(4):524-32. doi: 10.1017/S0963180111000260.


PMID- 21843331
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1746-4358 (Electronic)
IS  - 1746-4358 (Linking)
VI  - 6
IP  - 1
DP  - 2011 Aug 15
TI  - Iatrogenic newborn weight loss: knowledge translation using a study protocol for 
      your maternity setting.
PG  - 10
LID - 10.1186/1746-4358-6-10 [doi]
AB  - BACKGROUND: In our original study of newborn weight loss, we determined there
      were positive correlations among newborn weight loss, neonatal output, and the IV
      fluids mothers received before their babies' birth. Basically, an increase in
      maternal IV fluids is correlated to an increase in neonatal output and newborn
      weight loss. When assessing newborn weight change, our recommendation is to
      change baseline from birth weight to a weight measured at 24 hours. The purpose
      of this paper is to provide a protocol for clinicians to collect and analyze data
      from their own maternity site to determine if the newborns experience such an
      iatrogenic weight loss and to make decisions about how to assess newborn weight
      changes. METHODS: We recommend a prospective observational study with data
      collected about maternal fluids, neonatal output, and newborn weight
      measurements. The methods we suggest include specifics about recruitment, data
      collection, and data analysis. DISCUSSION: Quality assurance and research ethics 
      considerations are described. We also share practical information that we learned
      from our original study. Ultimately, to encourage knowledge translation and
      research uptake, we provide a protocol and sound advice to do a research study in
      your maternity setting.
FAU - Noel-Weiss, Joy
AU  - Noel-Weiss J
AD  - School of Nursing, University of Ottawa, 451 Smyth Road, Ottawa, ON, K1H 8M5,
      Canada. Joy.Noel-Weiss@uottawa.ca.
FAU - Woodend, A Kirsten
AU  - Woodend AK
FAU - Groll, Dianne L
AU  - Groll DL
LA  - eng
PT  - Journal Article
DEP - 20110815
PL  - England
TA  - Int Breastfeed J
JT  - International breastfeeding journal
JID - 101251562
PMC - PMC3178467
EDAT- 2011/08/17 06:00
MHDA- 2011/08/17 06:01
CRDT- 2011/08/17 06:00
PHST- 2011/02/21 00:00 [received]
PHST- 2011/08/15 00:00 [accepted]
PHST- 2011/08/17 06:00 [entrez]
PHST- 2011/08/17 06:00 [pubmed]
PHST- 2011/08/17 06:01 [medline]
AID - 1746-4358-6-10 [pii]
AID - 10.1186/1746-4358-6-10 [doi]
PST - epublish
SO  - Int Breastfeed J. 2011 Aug 15;6(1):10. doi: 10.1186/1746-4358-6-10.


PMID- 21843198
OWN - NLM
STAT- MEDLINE
DCOM- 20120719
LR  - 20220409
IS  - 1471-6712 (Electronic)
IS  - 0283-9318 (Linking)
VI  - 26
IP  - 1
DP  - 2012 Mar
TI  - My, your and our needs for safety and security: relatives' reflections on using
      information and communication technology in dementia care.
PG  - 104-12
LID - 10.1111/j.1471-6712.2011.00916.x [doi]
AB  - AIM: The present paper reports on a study aimed at describing relatives'
      reflections on different kinds of information and communication technology (ICT) 
      devices that are used or can be used in the daily care of persons with dementia. 
      BACKGROUND: Many persons with dementia continue living in their own homes, which 
      requires the support of their relatives. One way to meet the needs of relatives
      and persons with dementia is to use ICT. METHODS: An interview study was
      conducted in Sweden (2007-2008) with a purposive sample of 14 spouses of a person
      with dementia. Qualitative content analysis was used to identify categories and
      themes in the data. FINDINGS: Relatives' reflections on the use of ICT were
      described as ICT - a support in daily life, ICT - internal and external
      conditions and ICT - the decision to use or not use. Based on these categories, a
      theme was revealed: shifting between different perspectives: my, your and our
      needs for safety and security. CONCLUSION: Relatives struggle to create a
      situation of safety and security in daily life for themselves and the persons
      with dementia. ICT devices with the right functionality and used at the right
      time are regarded as useful in solving everyday problems. In the decision to use 
      or not use ICT, the opportunity to create a safe and secure environment
      overshadows potential ethical problems. Providing early information about ICT to 
      persons with dementia and their relatives could facilitate joint decision-making 
      regarding use of ICT.
CI  - (c) 2011 The Authors. Scandinavian Journal of Caring Sciences (c) 2011 Nordic
      College of Caring Science.
FAU - Olsson, Annakarin
AU  - Olsson A
AD  - Faculty of Health and Occupational Studies, University of Gavle, Gavle, Sweden.
      annakarin.olsson@hig.se
FAU - Engstrom, Maria
AU  - Engstrom M
FAU - Skovdahl, Kirsti
AU  - Skovdahl K
FAU - Lampic, Claudia
AU  - Lampic C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110815
PL  - Sweden
TA  - Scand J Caring Sci
JT  - Scandinavian journal of caring sciences
JID - 8804206
MH  - Aged
MH  - Aged, 80 and over
MH  - *Caregivers
MH  - Decision Making
MH  - Dementia/*therapy
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - *Home Nursing
MH  - Humans
MH  - *Information Systems
MH  - Male
MH  - *Patient Safety
MH  - Protective Devices
MH  - Qualitative Research
MH  - Self-Help Devices
MH  - Sweden
EDAT- 2011/08/17 06:00
MHDA- 2012/07/20 06:00
CRDT- 2011/08/17 06:00
PHST- 2011/08/17 06:00 [entrez]
PHST- 2011/08/17 06:00 [pubmed]
PHST- 2012/07/20 06:00 [medline]
AID - 10.1111/j.1471-6712.2011.00916.x [doi]
PST - ppublish
SO  - Scand J Caring Sci. 2012 Mar;26(1):104-12. doi: 10.1111/j.1471-6712.2011.00916.x.
      Epub 2011 Aug 15.


PMID- 21843067
OWN - NLM
STAT- MEDLINE
DCOM- 20111102
LR  - 20181201
IS  - 1744-8042 (Electronic)
IS  - 1462-2416 (Linking)
VI  - 12
IP  - 8
DP  - 2011 Aug
TI  - Pharmacogenetic testing to predict antipsychotic-induced weight gain: a
      systematic review.
PG  - 1213-27
LID - 10.2217/pgs.11.67 [doi]
AB  - Weight gain is an important side effect of antipsychotic drugs. Since the high
      interindividual difference in weight gain suggests that genetic factors play a
      role in this weight gain, studies have tried to identify these factors. Most of
      these studies were carried out in the past few years and focussed largely on
      receptor polymorphisms, although some tried to explain the variation in weight
      gain by differences in pharmacokinetics. Unfortunately, the results of these
      association studies are often conflicting, which makes it hard to apply this
      genetic knowledge in daily clinical practice. This article summarizes the
      findings of these association studies and focuses on differences in study
      methodology in an attempt to explain why study results could have been
      conflicting. Furthermore, the feasibility of genetic testing in today's clinical 
      practice is discussed, using a model that consists of four components; analytical
      validity, clinical validity, clinical utility and ethical, legal and social
      issues.
FAU - Risselada, Arne J
AU  - Risselada AJ
AD  - Department of Pharmacoepidemiology & Pharmacotherapy, Utrecht Institute for
      Pharmaceutical Sciences (UIPS), Utrecht University, PO Box 80082, 3508 TB
      Utrecht, The Netherlands.
FAU - Mulder, Hans
AU  - Mulder H
FAU - Heerdink, Eibert R
AU  - Heerdink ER
FAU - Egberts, Toine C G
AU  - Egberts TC
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
PL  - England
TA  - Pharmacogenomics
JT  - Pharmacogenomics
JID - 100897350
RN  - 0 (Antipsychotic Agents)
SB  - IM
MH  - Animals
MH  - Antipsychotic Agents/*adverse effects/pharmacokinetics
MH  - Genetic Testing
MH  - Genotype
MH  - Humans
MH  - Pharmacogenetics
MH  - Predictive Value of Tests
MH  - Psychotic Disorders/complications/metabolism
MH  - Reproducibility of Results
MH  - Weight Gain/*drug effects/*genetics
EDAT- 2011/08/17 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/08/17 06:00
PHST- 2011/08/17 06:00 [entrez]
PHST- 2011/08/17 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
AID - 10.2217/pgs.11.67 [doi]
PST - ppublish
SO  - Pharmacogenomics. 2011 Aug;12(8):1213-27. doi: 10.2217/pgs.11.67.


PMID- 21843063
OWN - NLM
STAT- MEDLINE
DCOM- 20111102
LR  - 20211203
IS  - 1744-8042 (Electronic)
IS  - 1462-2416 (Linking)
VI  - 12
IP  - 8
DP  - 2011 Aug
TI  - A hub for bench-to-bedside pharmacogenomic-based research.
PG  - 1095-8
LID - 10.2217/pgs.11.62 [doi]
AB  - In 2003 Duke University (Durham, NC, USA) launched the Institute for Genome
      Sciences & Policy (IGSP) as an interdisciplinary network of centers comprised of 
      scientists, engineers and physicians, as well as experts in law, business,
      economics public policy and ethics. Within this environment, the IGSP and its
      Center for Genomic Medicine form the hub for pharmacogenomic research discovery
      initiatives through collaborations with other scientific and clinical units at
      the Duke University Medical Center. The Center for Genomic Medicine specifically 
      focuses on developing strategies for translating and implementing pharmacogenomic
      discoveries into the clinical arena; therefore, by harnessing the resources of
      the IGSP as well as other complementary centers on campus, Duke University is
      poised to accelerate the development of novel pharmacgenomic paradigms for the
      prevention and treatment of disease. These new treatment paradigms can,
      potentially, ensure that the right dose of the right drug is prescribed to the
      right individual - an often stated goal of personalized medicine and
      pharmacogenomics.
FAU - Voora, Deepak
AU  - Voora D
AD  - Institute for Genome Sciences & Policy, Center for Genomic Medicine, 101 Science 
      Drive, Duke University, DUMC Box 3382, Durham, NC 27708, USA.
FAU - Ginsburg, Geoffrey S
AU  - Ginsburg GS
LA  - eng
PT  - Journal Article
PL  - England
TA  - Pharmacogenomics
JT  - Pharmacogenomics
JID - 100897350
SB  - IM
MH  - Academic Medical Centers
MH  - Academies and Institutes
MH  - Clinical Trials, Phase II as Topic
MH  - Clinical Trials, Phase III as Topic
MH  - Laboratories/organization & administration/trends
MH  - Pharmacogenetics/organization & administration/*trends
MH  - Precision Medicine
MH  - Research Support as Topic
MH  - Translational Research, Biomedical
EDAT- 2011/08/17 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/08/17 06:00
PHST- 2011/08/17 06:00 [entrez]
PHST- 2011/08/17 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
AID - 10.2217/pgs.11.62 [doi]
PST - ppublish
SO  - Pharmacogenomics. 2011 Aug;12(8):1095-8. doi: 10.2217/pgs.11.62.


PMID- 21842614
OWN - NLM
STAT- MEDLINE
DCOM- 20110830
LR  - 20211020
IS  - 1294-8322 (Print)
IS  - 1294-8322 (Linking)
VI  - 13
IP  - 2
DP  - 2011
TI  - Ethical issues in naturalistic versus controlled trials.
PG  - 173-82
AB  - Ethical core issues in research with human subjects are related to informed
      consent and risk-benefit assessment. This is valid for all types of studies.
      However, there has been much greater focus of ethical considerations on
      controlled clinical trials than on naturalistic trials, probably because the
      former are interventional in nature and may have unknown and perhaps severe
      somatic risks, whereas naturalistic studies seem not to intervene but only to
      observe, and therefore are assumed to have fewer or almost no risks. However,
      there are also ethical implications in naturalistic trials, although their weight
      is differently accentuated, more with potential, more with potential
      psychological burdens of the observational procedures and more with potential
      physical risks in interventional trials. This will be elaborated with examples of
      placebo-controlled trials and of incidental findings in screenings, of marketing 
      influences on observational studies, and of psychological burdens by survey
      interviews. The ethical implications will be analyzed within a more general
      framework. Finally, recommendations will be offered.
FAU - Helmchen, Hanfried
AU  - Helmchen H
AD  - Psychiatry and Psychotherapy Clinic, Charite - Universitatsmedizin Berlin,
      Germany. hanfried.helmchen@charite.de
LA  - eng
PT  - Journal Article
PL  - England
TA  - Dialogues Clin Neurosci
JT  - Dialogues in clinical neuroscience
JID - 101238198
SB  - IM
MH  - Clinical Trials as Topic/*ethics/methods
MH  - *Ethics, Research
MH  - Evidence-Based Medicine/*ethics/legislation & jurisprudence/statistics &
      numerical data
MH  - Humans
MH  - Mental Disorders/*therapy
MH  - Reproducibility of Results
MH  - Risk Assessment/*ethics
PMC - PMC3182002
EDAT- 2011/08/17 06:00
MHDA- 2011/08/31 06:00
CRDT- 2011/08/17 06:00
PHST- 2011/08/17 06:00 [entrez]
PHST- 2011/08/17 06:00 [pubmed]
PHST- 2011/08/31 06:00 [medline]
PST - ppublish
SO  - Dialogues Clin Neurosci. 2011;13(2):173-82.


PMID- 21842331
OWN - NLM
STAT- MEDLINE
DCOM- 20120424
LR  - 20211020
IS  - 1433-0407 (Electronic)
IS  - 0028-2804 (Linking)
VI  - 82
IP  - 12
DP  - 2011 Dec
TI  - [Lifestyle and cognition: what do we know from the aging and neurodegenerative
      brain?].
PG  - 1566-77
LID - 10.1007/s00115-011-3353-0 [doi]
AB  - Epidemiological studies demonstrated positive effects of continuous physical
      activity and balanced diet on cardiovascular fitness. In chronic
      neurodegenerative disorders, e.g. Parkinson's disease and Alzheimer's disease,
      physical activity has become a successful supportive symptomatic therapy.
      However, it has become evident that physical activity not only improves motor
      symptoms but also has high impact on cognition in both (elderly) healthy brain
      and neurodegenerative alterations in the CNS. Nutrition also has been reported to
      exert positive effects on brain function.Animal studies indicate an increased
      endogenous plasticity as the underlying mechanism in terms of activation of
      neuronal precursor cells in different brain areas, leading to improved brain
      function.First experimental studies in humans also show that physical activity
      and balanced nutrition increase the release of neurotrophic factors in the brain,
      increase the volume of grey matter in learning- and memory-associated brain
      regions and improve cognitive function. This phenomenon opens up noninvasive
      causal therapeutic options in neurodegenerative disorders and during
      aging-associated cognitive decline by inducing changes in lifestyle. This option 
      could provide a socioeconomically and ethically reasonable treatment for
      neurodegenerative disorders.The presented article summarizes the current
      knowledge from animal experiments and studies in humans. It provides an overview 
      of potential cellular and molecular candidate mechanisms and discusses novel
      translational clinical studies and first clinical applications.
FAU - Steiner, B
AU  - Steiner B
AD  - Klinik fur Neurologie, Charite-Universitatsmedizin Berlin, Charite Campus Mitte, 
      Chariteplatz 1, 10117 Berlin, Deutschland. barbara.steiner@charite.de
FAU - Witte, V
AU  - Witte V
FAU - Floel, A
AU  - Floel A
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Lebensstil und Kognition: Was wissen wir uber das alternde und neurodegenerativ
      veranderte Gehirn?
PL  - Germany
TA  - Nervenarzt
JT  - Der Nervenarzt
JID - 0400773
SB  - IM
MH  - *Aging
MH  - Animals
MH  - Brain/*physiopathology
MH  - *Cognition
MH  - Humans
MH  - *Life Style
MH  - *Models, Neurological
MH  - Neurodegenerative Diseases/pathology/*physiopathology
MH  - *Neuronal Plasticity
EDAT- 2011/08/16 06:00
MHDA- 2012/04/25 06:00
CRDT- 2011/08/16 06:00
PHST- 2011/08/16 06:00 [entrez]
PHST- 2011/08/16 06:00 [pubmed]
PHST- 2012/04/25 06:00 [medline]
AID - 10.1007/s00115-011-3353-0 [doi]
PST - ppublish
SO  - Nervenarzt. 2011 Dec;82(12):1566-77. doi: 10.1007/s00115-011-3353-0.


PMID- 21842138
OWN - NLM
STAT- MEDLINE
DCOM- 20111202
LR  - 20211020
IS  - 1573-3394 (Electronic)
IS  - 1065-3058 (Linking)
VI  - 19
IP  - 3
DP  - 2011 Sep
TI  - The biobank as an ethical subject.
PG  - 282-94
LID - 10.1007/s10728-011-0180-1 [doi]
AB  - This paper argues that a certain way of thinking about the function of the
      biobank-about what it does and is constructed for as a social institution aimed
      at 'some good'-can and should play a substantial role in an effective biobanking 
      ethic. It first exemplifies an 'institution shaped gap' in the current field of
      biobanking ethics. Next the biobank is conceptualized as a social institution
      that is apt for a certain kind of purposive functional definition such that we
      know it by what it does and what it is designed to do. This purpose is then
      characterized further as essentially incorporating the human goods the
      institution is designed to serve, such that it plays a useful and indispensible
      role in how it should operate, i.e. in the ethics and governance of biobanking.
      Finally the ethical scope and limitations of such a theory is clarified by a
      discussion of some theoretical objections and suggested practical examples of its
      application.
FAU - Cordell, Sean
AU  - Cordell S
AD  - Department of Philosophy, University of Birmingham, UK. sean.68@live.com
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Health Care Anal
JT  - Health care analysis : HCA : journal of health philosophy and policy
JID - 9432537
MH  - Bioethical Issues
MH  - Biological Specimen Banks/*ethics/organization & administration
MH  - *Ethics, Institutional
MH  - Humans
EDAT- 2011/08/16 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/08/16 06:00
PHST- 2011/08/16 06:00 [entrez]
PHST- 2011/08/16 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/s10728-011-0180-1 [doi]
PST - ppublish
SO  - Health Care Anal. 2011 Sep;19(3):282-94. doi: 10.1007/s10728-011-0180-1.


PMID- 21841764
OWN - NLM
STAT- MEDLINE
DCOM- 20111004
LR  - 20211020
IS  - 1940-087X (Electronic)
IS  - 1940-087X (Linking)
IP  - 53
DP  - 2011 Jul 30
TI  - Isolation of human islets from partially pancreatectomized patients.
LID - 10.3791/2962 [doi]
LID - 2962 [pii]
AB  - Investigations into the pathogenesis of type 2 diabetes and islets of Langerhans 
      malfunction (1) have been hampered by the limited availability of type 2 diabetic
      islets from organ donors(2). Here we share our protocol for isolating islets from
      human pancreatic tissue obtained from type 2 diabetic and non-diabetic patients
      who have undergone partial pancreatectomy due to different pancreatic diseases
      (benign or malignant pancreatic tumors, chronic pancreatitis, and common bile
      duct or duodenal tumors). All patients involved gave their consent to this study,
      which had also been approved by the local ethics committee. The surgical
      specimens were immediately delivered to the pathologist who selected soft and
      healthy appearing pancreatic tissue for islet isolation, retaining the damaged
      tissue for diagnostic purposes. We found that to isolate more than 1,000 islets, 
      we had to begin with at least 2 g of pancreatic tissue. Also essential to our
      protocol was to visibly distend the tissue when injecting the enzyme-containing
      media and subsequently mince it to aid digestion by increasing the surface area. 
      To extend the applicability of our protocol to include the occasional case in
      which a large amount (>15g) of human pancreatic tissue is available , we used a
      Ricordi chamber (50 ml) to digest the tissue. During digestion, we manually shook
      the Ricordi chamber(3) at an intensity that varied by specimen according to its
      level of tissue fibrosis. A discontinous Ficoll gradient was then used to
      separate the islets from acinar tissue. We noted that the tissue pellet should be
      small enough to be homogenously resuspended in Ficoll medium with a density of
      1.125 g/ml. After isolation, we cultured the islets under stress free conditions 
      (no shaking or rotation) with 5% CO(2;) at 37 degrees C for at least 48 h in
      order to facilitate their functional recovery. Widespread application of our
      protocol and its future improvement could enable the timely harvesting of large
      quantities of human islets from diabetic and clinically matched non-diabetic
      subjects, greatly advancing type 2 diabetes research.
FAU - Botticher, Gregor
AU  - Botticher G
AD  - Department of GI-, Thorax- and Vascular Surgery, University Hospital Carl Gustav 
      Carus, University of Technology Dresden.
FAU - Sturm, Doroth
AU  - Sturm D
FAU - Ehehalt, Florian
AU  - Ehehalt F
FAU - Knoch, Klaus P
AU  - Knoch KP
FAU - Kersting, Stephan
AU  - Kersting S
FAU - Grutzmann, Robert
AU  - Grutzmann R
FAU - Baretton, Gustavo B
AU  - Baretton GB
FAU - Solimena, Michele
AU  - Solimena M
FAU - Saeger, Hans D
AU  - Saeger HD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Video-Audio Media
DEP - 20110730
PL  - United States
TA  - J Vis Exp
JT  - Journal of visualized experiments : JoVE
JID - 101313252
SB  - IM
MH  - Cytological Techniques/*methods
MH  - Diabetes Mellitus, Type 2/pathology
MH  - Humans
MH  - Islets of Langerhans/*cytology
MH  - Pancreas/*cytology/surgery
MH  - Pancreatectomy
PMC - PMC3197443
EDAT- 2011/08/16 06:00
MHDA- 2011/10/05 06:00
CRDT- 2011/08/16 06:00
PHST- 2011/08/16 06:00 [entrez]
PHST- 2011/08/16 06:00 [pubmed]
PHST- 2011/10/05 06:00 [medline]
AID - 2962 [pii]
AID - 10.3791/2962 [doi]
PST - epublish
SO  - J Vis Exp. 2011 Jul 30;(53). pii: 2962. doi: 10.3791/2962.


PMID- 21841587
OWN - NLM
STAT- MEDLINE
DCOM- 20111102
LR  - 20191112
IS  - 1750-8460 (Print)
IS  - 1750-8460 (Linking)
VI  - 72
IP  - 8
DP  - 2011 Aug
TI  - Advance care planning: ethical and clinical implications for hospital medicine.
PG  - 437-40
AB  - Advance care planning takes place 'in advance of' anticipated loss of capacity
      with the aim of informing the best interests judgments required when capacity is 
      later lost. It is an ethically and clinically distinct subset of general care
      planning.
FAU - Randall, Fiona
AU  - Randall F
AD  - Earl Mountbatten Hospice, Isle of Wight Primary Care Trust, Newport, Isle of
      Wight PO30 2ER, UK.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Br J Hosp Med (Lond)
JT  - British journal of hospital medicine (London, England : 2005)
JID - 101257109
SB  - IM
MH  - Advance Care Planning/*ethics
MH  - Advance Directives
MH  - Decision Making
MH  - *Hospitals
MH  - Humans
MH  - Planning Techniques
EDAT- 2011/08/16 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/08/16 06:00
PHST- 2011/08/16 06:00 [entrez]
PHST- 2011/08/16 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
AID - 10.12968/hmed.2011.72.8.437 [doi]
PST - ppublish
SO  - Br J Hosp Med (Lond). 2011 Aug;72(8):437-40. doi: 10.12968/hmed.2011.72.8.437.


PMID- 21841147
OWN - NLM
STAT- MEDLINE
DCOM- 20121101
LR  - 20220318
IS  - 1525-1489 (Electronic)
IS  - 0885-0666 (Linking)
VI  - 27
IP  - 4
DP  - 2012 Jul-Aug
TI  - Variability in the determination of death after cardiac arrest: a review of
      guidelines and statements.
PG  - 238-52
LID - 10.1177/0885066610396993 [doi]
AB  - INTRODUCTION: The reemergence of organ donation after circulatory determination
      of death (DCDD) in Canada demands the establishment of clear, evidence-based
      guidelines for the determination of death. The primary purpose of this study was 
      to investigate the variability in specific criteria, diagnostic tests, and
      recommended wait periods for the determination of death after cardiac arrest.
      METHODS: We used PubMed and Web of Science to perform a structured search of the 
      medical literature for articles published up to January 1, 2010. We also
      performed an unstructured search of the internet for unrestricted, readily
      available, nonjournal sources. We limited the search to countries that are most
      active in DCDD. RESULTS: A total of 26 documents were retrieved; 21 medical
      professional society/institution statements and 5 national/international
      guidelines. Specific criteria for the determination of death after cardiac arrest
      were cited in 24 documents: 14 recommend cardiocirculatory criteria alone; 6
      oblige the requirement of a prolonged waiting period after declaration to ensure 
      neurological death; 3 recommend following "accepted medical practice" without
      specific details; and 1 leaves the definition up to "national authorities." Only 
      16 of the documents require specific diagnostic procedures with unresponsiveness,
      absent arterial pulse and apnea cited the most consistently. Specific wait
      periods after declaration are required for the determination of death after
      cardiac arrest in 24 documents, cited times range from 2 to 10 minutes, with a
      5-minute period the most frequent. CONCLUSIONS: This review is the first to
      document the variability of guidelines and statements for the determination of
      death after cardiac arrest, in countries where the practice of DCDD is becoming
      increasingly common. The scarcity of peer-reviewed published guidelines in the
      medical literature exemplifies the need for further investigation. We believe
      these results will inform the ethical discussions surrounding the determination
      of death after cardiac arrest. Clear and consistent guidelines based on evidence 
      are needed to fulfill medical, ethical, and legal obligation and to ensure public
      trust.
FAU - Dhanani, Sonny
AU  - Dhanani S
AD  - Pediatric Critical Care, Children's Hospital of Eastern Ontario, Faculty of
      Medicine, University of Ottawa, Canada. sdhanani@cheo.on.ca
FAU - Hornby, Laura
AU  - Hornby L
FAU - Ward, Roxanne
AU  - Ward R
FAU - Shemie, Sam
AU  - Shemie S
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110812
PL  - United States
TA  - J Intensive Care Med
JT  - Journal of intensive care medicine
JID - 8610344
SB  - IM
MH  - *Death
MH  - Heart Arrest/*mortality
MH  - Humans
MH  - *Policy Making
MH  - *Practice Guidelines as Topic
EDAT- 2011/08/16 06:00
MHDA- 2012/11/02 06:00
CRDT- 2011/08/16 06:00
PHST- 2011/08/16 06:00 [entrez]
PHST- 2011/08/16 06:00 [pubmed]
PHST- 2012/11/02 06:00 [medline]
AID - 0885066610396993 [pii]
AID - 10.1177/0885066610396993 [doi]
PST - ppublish
SO  - J Intensive Care Med. 2012 Jul-Aug;27(4):238-52. doi: 10.1177/0885066610396993.
      Epub 2011 Aug 12.


PMID- 21840907
OWN - NLM
STAT- MEDLINE
DCOM- 20120325
LR  - 20111019
IS  - 1460-2350 (Electronic)
IS  - 0268-1161 (Linking)
VI  - 26
IP  - 11
DP  - 2011 Nov
TI  - Non-invasive prenatal diagnosis for aneuploidy: toward an integral ethical
      assessment.
PG  - 2915-7
LID - 10.1093/humrep/der268 [doi]
AB  - The great promise of the pending introduction of non-invasive prenatal diagnosis 
      (NIPD) for trisomy 21 (18 and 13) is that it enables one-step, early and safe
      testing for these abnormalities. The ethical debate so far has been limited to
      possible drawbacks of routine access to this type of testing: normalization of
      testing and abortion and adverse effects on autonomous decision-making. We
      address the ethical implications of the fact that routine NIPD affects the scope 
      and strategy of current prenatal screening cascades. A decision is needed whether
      complementary (invasive) testing remains in place in order to avoid a loss of
      information as compared with current practice. If so, the supposed advantages of 
      NIPD may be less significant than generally assumed. Accumulation of tests
      challenges informed consent and proportionality. Therefore, an ethical evaluation
      of the implications of NIPD for the prenatal screening strategy as a whole is
      needed.
FAU - de Jong, Antina
AU  - de Jong A
AD  - Faculty of Health, Medicine & Life Sciences, Department of Health, Ethics &
      Society, and GROW, School for Oncology and Developmental Biology, Maastricht
      University, PO Box 616, 6200 MD Maastricht, The Netherlands.
      at.dejong@maastrichtuniversity.nl
FAU - Dondorp, Wybo J
AU  - Dondorp WJ
FAU - Frints, Suzanna G M
AU  - Frints SG
FAU - de Die-Smulders, Christine E M
AU  - de Die-Smulders CE
FAU - de Wert, Guido M W R
AU  - de Wert GM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110812
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - *Aneuploidy
MH  - Chromosomes, Human, Pair 13/genetics
MH  - Chromosomes, Human, Pair 18/genetics
MH  - DNA/metabolism
MH  - Decision Making
MH  - Down Syndrome/*diagnosis
MH  - Ethics, Medical
MH  - Female
MH  - Genetic Testing/methods
MH  - Humans
MH  - Pregnancy
MH  - Prenatal Diagnosis/*methods
EDAT- 2011/08/16 06:00
MHDA- 2012/03/27 06:00
CRDT- 2011/08/16 06:00
PHST- 2011/08/16 06:00 [entrez]
PHST- 2011/08/16 06:00 [pubmed]
PHST- 2012/03/27 06:00 [medline]
AID - der268 [pii]
AID - 10.1093/humrep/der268 [doi]
PST - ppublish
SO  - Hum Reprod. 2011 Nov;26(11):2915-7. doi: 10.1093/humrep/der268. Epub 2011 Aug 12.


PMID- 21840637
OWN - NLM
STAT- MEDLINE
DCOM- 20120120
LR  - 20211203
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 73
IP  - 7
DP  - 2011 Oct
TI  - Racial taxonomy in genomics.
PG  - 1019-27
LID - 10.1016/j.socscimed.2011.07.003 [doi]
AB  - This article examines the reflexive, biosocial nature of genomic meaning making
      around race, drawing on discourse analysis of 732 articles on genomics and race
      published from the years 1986-2010, in-depth interviews with 36 of the world's
      most elite genomics researchers, interviews with 15 critics, policymakers, and
      trainees involved in debates over race, and participant observation at a core
      genotyping facility that specializes in ancestry estimation. I reveal how
      biomedical researchers identify with, value, and make sense of the taxonomies
      they construct. My analysis goes beyond a consideration of instrumental
      rationales to analyze the experiential and political motivations that shape how
      researchers get involved in racial ethical dilemmas. I theorize taxonomic
      practice as a reflexive form of biosociality, a conscious shaping of social
      notions about biology and race to produce a future that researchers themselves
      want to live in. I demonstrate how reflexive biosociality paradoxically leads
      researchers to advance social explanations for race while investing in genomics
      as a solution to racial quandaries.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Bliss, Catherine
AU  - Bliss C
AD  - Brown University, Africana Studies, 155 Angell St Box 1904, Providence, RI 02912,
      United States. Catherine_Bliss@brown.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20110728
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Adult
MH  - Canada
MH  - *Genomics
MH  - Humans
MH  - Interviews as Topic
MH  - Middle Aged
MH  - Racial Groups/*genetics
MH  - Research Personnel/psychology
MH  - United States
EDAT- 2011/08/16 06:00
MHDA- 2012/01/21 06:00
CRDT- 2011/08/16 06:00
PHST- 2010/10/27 00:00 [received]
PHST- 2011/07/01 00:00 [revised]
PHST- 2011/07/01 00:00 [accepted]
PHST- 2011/08/16 06:00 [entrez]
PHST- 2011/08/16 06:00 [pubmed]
PHST- 2012/01/21 06:00 [medline]
AID - S0277-9536(11)00443-6 [pii]
AID - 10.1016/j.socscimed.2011.07.003 [doi]
PST - ppublish
SO  - Soc Sci Med. 2011 Oct;73(7):1019-27. doi: 10.1016/j.socscimed.2011.07.003. Epub
      2011 Jul 28.


PMID- 21839787
OWN - NLM
STAT- MEDLINE
DCOM- 20111227
LR  - 20131121
IS  - 1873-4863 (Electronic)
IS  - 0168-1656 (Linking)
VI  - 155
IP  - 4
DP  - 2011 Oct 10
TI  - In vitro selection and characterization of DNA aptamers recognizing
      chloramphenicol.
PG  - 361-9
LID - 10.1016/j.jbiotec.2011.06.043 [doi]
AB  - Chloramphenicol (Cam), although an effective antibiotic, has lost favour due to
      some fatal side effects. Thus there is an urgent need for rapid and sensitive
      methods to detect residues in food, feed and environment. We engineered DNA
      aptamers that recognize Cam as their target, by conducting in vitro selections.
      Aptamers are nucleic acid recognition elements that are highly specific and
      sensitive towards their targets and can be synthetically produced in an
      animal-friendly manner, making them ethical innovative alternatives to
      antibodies. None of the isolated aptamers in this study shared sequence homology 
      or structural similarities with each other, indicating that specific Cam
      recognition could be achieved by various DNA sequences under the selection
      conditions used. Analyzing the binding affinities of the sequences, demonstrated 
      that dissociation constants (K(d)) in the extremely low micromolar range, which
      were lower than those previously reported for Cam-specific RNA aptamers, were
      achieved. The two best aptamers had G rich (>35%) nucleotide regions, an
      attribute distinguishing them from the rest and apparently responsible for their 
      high selectivity and affinity (K(d) approximately 0.8 and 1muM respectively).
      These aptamers open up possibilities to allow easy detection of Cam via
      aptamer-based biosensors.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Mehta, Jaytry
AU  - Mehta J
AD  - University of Antwerp, Department of Biology, Laboratory for Ecophysiology,
      Biochemistry and Toxicology, Groenenborgerlaan, Antwerp, Belgium.
      Jaytry.Mehta@ua.ac.be
FAU - Van Dorst, Bieke
AU  - Van Dorst B
FAU - Rouah-Martin, Elsa
AU  - Rouah-Martin E
FAU - Herrebout, Wouter
AU  - Herrebout W
FAU - Scippo, Marie-Louise
AU  - Scippo ML
FAU - Blust, Ronny
AU  - Blust R
FAU - Robbens, Johan
AU  - Robbens J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110804
PL  - Netherlands
TA  - J Biotechnol
JT  - Journal of biotechnology
JID - 8411927
RN  - 0 (Aptamers, Nucleotide)
RN  - 66974FR9Q1 (Chloramphenicol)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Aptamers, Nucleotide/*chemistry
MH  - Base Sequence
MH  - Biosensing Techniques
MH  - Chloramphenicol/*analysis
MH  - DNA/*chemistry
MH  - Humans
MH  - Kinetics
MH  - Molecular Sequence Data
MH  - Nucleic Acid Conformation
EDAT- 2011/08/16 06:00
MHDA- 2011/12/28 06:00
CRDT- 2011/08/16 06:00
PHST- 2010/12/31 00:00 [received]
PHST- 2011/05/02 00:00 [revised]
PHST- 2011/06/24 00:00 [accepted]
PHST- 2011/08/16 06:00 [entrez]
PHST- 2011/08/16 06:00 [pubmed]
PHST- 2011/12/28 06:00 [medline]
AID - S0168-1656(11)00450-0 [pii]
AID - 10.1016/j.jbiotec.2011.06.043 [doi]
PST - ppublish
SO  - J Biotechnol. 2011 Oct 10;155(4):361-9. doi: 10.1016/j.jbiotec.2011.06.043. Epub 
      2011 Aug 4.


PMID- 21839453
OWN - NLM
STAT- MEDLINE
DCOM- 20120120
LR  - 20161229
IS  - 1879-3479 (Electronic)
IS  - 0020-7292 (Linking)
VI  - 115
IP  - 1
DP  - 2011 Oct
TI  - Legal and ethical issues in fetal surgery.
PG  - 80-3
LID - 10.1016/j.ijgo.2011.07.007 [doi]
AB  - Recent research in the USA has shown the advantages for children's welfare of
      open fetal surgery over postnatal treatment for myelomeningocele. However, a
      balance must be struck between complications of premature birth risked by
      prenatal surgery and the long-term advantages for affected children's health,
      including mobility and neurologic capacity. Risks for women are repeated surgery 
      for intervention and delivery. The research raises legal and ethical questions
      about how fetal interests should influence women's choices, and whether women may
      decline interventions in their pregnancies that offer their children lifelong
      advantages. Beyond fetal interests and women's preferences are state interests in
      fetal life, which in the USA and elsewhere have been expressed in judicially
      authorized cesarean deliveries. Underlying issues are the nature of fetal
      interests; contrasting entitlements to care from their mothers of fetuses and
      born children; healthcare providers' responsibilities toward fetuses; and duties 
      of care, information, and advice to pregnant women.
CI  - Copyright (c) 2011 International Federation of Gynecology and Obstetrics.
      Published by Elsevier Ireland Ltd. All rights reserved.
FAU - Dickens, Bernard M
AU  - Dickens BM
AD  - Faculty of Law, Faculty of Medicine and Joint Centre for Bioethics, University of
      Toronto, Toronto, Canada. bernard.dickens@utoronto.ca
FAU - Cook, Rebecca J
AU  - Cook RJ
LA  - eng
PT  - Journal Article
DEP - 20110811
PL  - United States
TA  - Int J Gynaecol Obstet
JT  - International journal of gynaecology and obstetrics: the official organ of the
      International Federation of Gynaecology and Obstetrics
JID - 0210174
SB  - IM
MH  - Ethics, Medical
MH  - Female
MH  - Fetal Diseases/*surgery
MH  - Fetal Therapies/ethics/*methods
MH  - Humans
MH  - Infant Welfare
MH  - Infant, Newborn
MH  - *Legislation, Medical
MH  - Life
MH  - Meningomyelocele/surgery
MH  - Patient Education as Topic
MH  - Pregnancy
MH  - Spinal Dysraphism/surgery
MH  - United States
EDAT- 2011/08/16 06:00
MHDA- 2012/01/21 06:00
CRDT- 2011/08/16 06:00
PHST- 2011/08/16 06:00 [entrez]
PHST- 2011/08/16 06:00 [pubmed]
PHST- 2012/01/21 06:00 [medline]
AID - S0020-7292(11)00332-8 [pii]
AID - 10.1016/j.ijgo.2011.07.007 [doi]
PST - ppublish
SO  - Int J Gynaecol Obstet. 2011 Oct;115(1):80-3. doi: 10.1016/j.ijgo.2011.07.007.
      Epub 2011 Aug 11.


PMID- 21839450
OWN - NLM
STAT- MEDLINE
DCOM- 20120120
LR  - 20161229
IS  - 1879-3479 (Electronic)
IS  - 0020-7292 (Linking)
VI  - 115
IP  - 1
DP  - 2011 Oct
TI  - Ethical issues in the management of severely disabled women with gynecologic
      problems.
PG  - 86-7
LID - 10.1016/j.ijgo.2011.07.003 [doi]
CN  - FIGO Committee for Ethical Aspects of Human Reproduction and Women's Health
LA  - eng
PT  - Journal Article
DEP - 20110811
PL  - United States
TA  - Int J Gynaecol Obstet
JT  - International journal of gynaecology and obstetrics: the official organ of the
      International Federation of Gynaecology and Obstetrics
JID - 0210174
SB  - IM
MH  - Decision Making/ethics
MH  - *Disabled Persons
MH  - *Ethics, Medical
MH  - Female
MH  - Gynecology/*ethics
MH  - Humans
MH  - Hygiene
MH  - Menstruation
MH  - Pregnancy
MH  - Sterilization, Reproductive/ethics
EDAT- 2011/08/16 06:00
MHDA- 2012/01/21 06:00
CRDT- 2011/08/16 06:00
PHST- 2011/08/16 06:00 [entrez]
PHST- 2011/08/16 06:00 [pubmed]
PHST- 2012/01/21 06:00 [medline]
AID - S0020-7292(11)00328-6 [pii]
AID - 10.1016/j.ijgo.2011.07.003 [doi]
PST - ppublish
SO  - Int J Gynaecol Obstet. 2011 Oct;115(1):86-7. doi: 10.1016/j.ijgo.2011.07.003.
      Epub 2011 Aug 11.


PMID- 21839448
OWN - NLM
STAT- MEDLINE
DCOM- 20120120
LR  - 20161229
IS  - 1879-3479 (Electronic)
IS  - 0020-7292 (Linking)
VI  - 115
IP  - 1
DP  - 2011 Oct
TI  - Ethical guidelines regarding interventions for fetal wellbeing.
PG  - 92
LID - 10.1016/j.ijgo.2011.07.006 [doi]
CN  - FIGO Committee for Ethical Aspects of Human Reproduction and Women's Health
CN  - International Federation of Gynecology and Obstetrics
LA  - eng
PT  - Journal Article
PT  - Practice Guideline
DEP - 20110812
PL  - United States
TA  - Int J Gynaecol Obstet
JT  - International journal of gynaecology and obstetrics: the official organ of the
      International Federation of Gynaecology and Obstetrics
JID - 0210174
SB  - IM
MH  - *Ethics, Medical
MH  - Female
MH  - Fetal Therapies/*ethics
MH  - *Human Rights
MH  - Humans
MH  - Informed Consent
MH  - Pregnancy
EDAT- 2011/08/16 06:00
MHDA- 2012/01/21 06:00
CRDT- 2011/08/16 06:00
PHST- 2011/08/16 06:00 [entrez]
PHST- 2011/08/16 06:00 [pubmed]
PHST- 2012/01/21 06:00 [medline]
AID - S0020-7292(11)00331-6 [pii]
AID - 10.1016/j.ijgo.2011.07.006 [doi]
PST - ppublish
SO  - Int J Gynaecol Obstet. 2011 Oct;115(1):92. doi: 10.1016/j.ijgo.2011.07.006. Epub 
      2011 Aug 12.


PMID- 21839317
OWN - NLM
STAT- MEDLINE
DCOM- 20111019
LR  - 20180714
IS  - 1097-6787 (Electronic)
IS  - 0190-9622 (Linking)
VI  - 65
IP  - 3
DP  - 2011 Sep
TI  - The empty specimen bottle: legal, moral, and ethical considerations for the
      dermatologist and dermatopathologist.
PG  - 621-623
LID - S0190-9622(11)00543-3 [pii]
LID - 10.1016/j.jaad.2011.04.020 [doi]
FAU - Grant-Kels, Jane M
AU  - Grant-Kels JM
AD  - Department of Dermatology, Director of Dermatopathology, Cutaneous Oncology
      Center and Dermatology Residency, University of Connecticut Health Center,
      Farmington, Connecticut. Electronic address: grant@uchc.edu.
FAU - Kels, Barry D
AU  - Kels BD
AD  - Director of Risk Management, Associate Professor of Surgery, University of
      Connecticut Health Center, Farmington, Connecticut.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Acad Dermatol
JT  - Journal of the American Academy of Dermatology
JID - 7907132
SB  - IM
MH  - Aged
MH  - Biopsy
MH  - Dermatology/*ethics
MH  - Female
MH  - Humans
MH  - Liability, Legal
MH  - Medical Errors/ethics
MH  - *Moral Obligations
MH  - Patient Rights
MH  - Skin Neoplasms/*diagnosis/pathology
MH  - *Specimen Handling
MH  - Truth Disclosure/*ethics
EDAT- 2011/08/16 06:00
MHDA- 2011/10/20 06:00
CRDT- 2011/08/16 06:00
PHST- 2011/03/30 00:00 [received]
PHST- 2011/04/22 00:00 [revised]
PHST- 2011/04/24 00:00 [accepted]
PHST- 2011/08/16 06:00 [entrez]
PHST- 2011/08/16 06:00 [pubmed]
PHST- 2011/10/20 06:00 [medline]
AID - S0190-9622(11)00543-3 [pii]
AID - 10.1016/j.jaad.2011.04.020 [doi]
PST - ppublish
SO  - J Am Acad Dermatol. 2011 Sep;65(3):621-623. doi: 10.1016/j.jaad.2011.04.020.


PMID- 21839043
OWN - NLM
STAT- MEDLINE
DCOM- 20120515
LR  - 20220330
IS  - 1873-1570 (Electronic)
IS  - 0300-9572 (Linking)
VI  - 83
IP  - 1
DP  - 2012 Jan
TI  - Guidance for ambulance personnel on decisions and situations related to
      out-of-hospital CPR.
PG  - 27-31
LID - 10.1016/j.resuscitation.2011.07.028 [doi]
AB  - Ethical guidelines on out-of-hospital cardio-pulmonary resuscitation (CPR) are
      designed to provide substantial guidance for the people who have to make
      decisions and deal with situations in the real world. The crucial question is
      whether it is possible to formulate practical guidelines that will make things
      somewhat easier for ambulance personnel. The aims of this article are to address 
      the ethical aspects related to out-of-hospital CPR, primarily to decisions on not
      starting or terminating resuscitation attempts, using the views and experience of
      ambulance personnel as a starting point, and to summarise the key points in a
      practice guideline on the subject.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Agard, Anders
AU  - Agard A
AD  - Sahlgrenska Academy, Institute of Medicine, Gothenburg, Sweden.
      anders.s.agard@vgregion.se
FAU - Herlitz, Johan
AU  - Herlitz J
FAU - Castren, Maaret
AU  - Castren M
FAU - Jonsson, Lars
AU  - Jonsson L
FAU - Sandman, Lars
AU  - Sandman L
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110810
PL  - Ireland
TA  - Resuscitation
JT  - Resuscitation
JID - 0332173
SB  - IM
MH  - Allied Health Personnel/*education
MH  - *Ambulances
MH  - Cardiopulmonary Resuscitation/education/*standards
MH  - *Decision Making
MH  - Guideline Adherence
MH  - Humans
MH  - Out-of-Hospital Cardiac Arrest/*therapy
MH  - *Practice Guidelines as Topic
EDAT- 2011/08/16 06:00
MHDA- 2012/05/16 06:00
CRDT- 2011/08/16 06:00
PHST- 2011/03/15 00:00 [received]
PHST- 2011/07/15 00:00 [revised]
PHST- 2011/07/20 00:00 [accepted]
PHST- 2011/08/16 06:00 [entrez]
PHST- 2011/08/16 06:00 [pubmed]
PHST- 2012/05/16 06:00 [medline]
AID - S0300-9572(11)00466-7 [pii]
AID - 10.1016/j.resuscitation.2011.07.028 [doi]
PST - ppublish
SO  - Resuscitation. 2012 Jan;83(1):27-31. doi: 10.1016/j.resuscitation.2011.07.028.
      Epub 2011 Aug 10.


PMID- 21839002
OWN - NLM
STAT- MEDLINE
DCOM- 20110929
LR  - 20150826
IS  - 0443-5117 (Print)
IS  - 0443-5117 (Linking)
VI  - 49
IP  - 3
DP  - 2011 May-Jun
TI  - [Bioethics and intercultural health: notes to a necessary and possible
      connection].
PG  - 325-30
AB  - One of the current challenges of bioethics is to look at diversity in health
      care, and especially avoid hegemonic criteria established as normative and do not
      include diversity. In some situations, such policies contributed to the exclusion
      of the difference in what is supposedly enshrined as "normal." This includes the 
      difficulties that are generated against health issues when approached from a
      cultural perspective, because the diseases are not equal and do not manifest the 
      same way in different cultures, i.e. there are different ways of getting sick,
      which can be determined culturally. At the same time, bioethics is a proposal
      about the ethical conflicts related to life in general, so this article aims to
      explore how to structure the connection between an ethic of life (bioethics) and 
      health from an intercultural perspective.
FAU - Mocellin-Raymundo, Marcia
AU  - Mocellin-Raymundo M
AD  - Departamento de Historia y Filosofia de la Medicina, Facultad de Medicina,
      Universidad Nacional Autonoma de Mexico, Distrito Federal, Mexico.
      marciamocellin@gmail.com
FAU - Viesca-Trevino, Carlos
AU  - Viesca-Trevino C
FAU - Gutierrez-Martinez, Daniel
AU  - Gutierrez-Martinez D
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Bioetica y salud intercultural: apuntamientos para una conexion necesaria y
      posible.
PL  - Mexico
TA  - Rev Med Inst Mex Seguro Soc
JT  - Revista medica del Instituto Mexicano del Seguro Social
JID - 101243727
SB  - IM
MH  - *Bioethics
MH  - *Cultural Characteristics
MH  - Humans
EDAT- 2011/08/16 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/08/16 06:00
PHST- 2011/08/16 06:00 [entrez]
PHST- 2011/08/16 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
PST - ppublish
SO  - Rev Med Inst Mex Seguro Soc. 2011 May-Jun;49(3):325-30.


PMID- 21838970
OWN - NLM
STAT- MEDLINE
DCOM- 20111212
LR  - 20211020
IS  - 2769-6677 (Electronic)
IS  - 1559-6109 (Linking)
VI  - 50
IP  - 4
DP  - 2011 Jul
TI  - Ethics and animal numbers: informal analyses, uncertain sample sizes, inefficient
      replications, and type I errors.
PG  - 445-53
AB  - To obtain approval for the use vertebrate animals in research, an investigator
      must assure an ethics committee that the proposed number of animals is the
      minimum necessary to achieve a scientific goal. How does an investigator make
      that assurance? A power analysis is most accurate when the outcome is known
      before the study, which it rarely is. A 'pilot study' is appropriate only when
      the number of animals used is a tiny fraction of the numbers that will be
      invested in the main study because the data for the pilot animals cannot
      legitimately be used again in the main study without increasing the rate of type 
      I errors (false discovery). Traditional significance testing requires the
      investigator to determine the final sample size before any data are collected and
      then to delay analysis of any of the data until all of the data are final. An
      investigator often learns at that point either that the sample size was larger
      than necessary or too small to achieve significance. Subjects cannot be added at 
      this point in the study without increasing type I errors. In addition, journal
      reviewers may require more replications in quantitative studies than are truly
      necessary. Sequential stopping rules used with traditional significance tests
      allow incremental accumulation of data on a biomedical research problem so that
      significance, replicability, and use of a minimal number of animals can be
      assured without increasing type I errors.
CI  - Copyright 2011 by the American Association for Laboratory Animal Science
FAU - Fitts, Douglas A
AU  - Fitts DA
AD  - Office of Animal Welfare, University of Washington, Seattle, Washington, USA.
      dfitts@u.washington.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Assoc Lab Anim Sci
JT  - Journal of the American Association for Laboratory Animal Science : JAALAS
JID - 101269489
SB  - IM
MH  - Animal Care Committees
MH  - Animal Experimentation/*ethics
MH  - *Data Interpretation, Statistical
MH  - *Research Design
MH  - *Sample Size
PMC - PMC3148647
EDAT- 2011/08/16 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/08/16 06:00
PHST- 2011/08/16 06:00 [entrez]
PHST- 2011/08/16 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
PST - ppublish
SO  - J Am Assoc Lab Anim Sci. 2011 Jul;50(4):445-53.


PMID- 21838884
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1756-0500 (Electronic)
IS  - 1756-0500 (Linking)
VI  - 4
DP  - 2011 Aug 12
TI  - The Taiwan Birth Panel Study: a prospective cohort study for environmentally-
      related child health.
PG  - 291
LID - 10.1186/1756-0500-4-291 [doi]
AB  - BACKGROUND: The Taiwan Birth Panel Study (TBPS) is a prospective follow-up study 
      to investigate the development of child health and disease in relation to
      in-utero and/or early childhood environmental exposures. The rationale behind the
      establishment of such a cohort includes the magnitude of potential environmental 
      exposures, the timing of exposure window, fatal and children's susceptibility to 
      toxicants, early exposure delayed effects, and low-level or unknown
      neurodevelopmental toxicants. METHODS: A total of 486 mother-infant paired was
      enrolled from April 2004 to January 2005 in this study. Maternal blood before
      delivery, placenta and umbilical cord blood at birth, and mothers' urine after
      delivery were collected. The follow-up was scheduled at birth, 4, 6 months, and
      1, 2, 3 and 5 years. The children's blood, urine, hair, and saliva were collected
      at 2 years of age and children's urine was collected at 5 years of age as well.
      The study has been approved by the ethical committee of National Taiwan
      University Hospital. All the subjects signed the inform consent on entering the
      study and each of the follow up. RESULTS: Through this prospective birth cohort, 
      the main health outcomes were focused on child growth, neurodevelopment,
      behaviour problem and atopic diseases. We investigated the main prenatal and
      postnatal factors including smoking, heavy metals, perfluorinated chemicals, and 
      non-persistent pesticides under the consideration of interaction of the
      environment and genes. CONCLUSIONS: This cohort study bridges knowledge gaps and 
      answers unsolved issues in the low-level, prenatal or postnatal, and multiple
      exposures, genetic effect modification, and the initiation and progression of
      "environmentally-related childhood diseases."
FAU - Hsieh, Chia-Jung
AU  - Hsieh CJ
AD  - Institute of Occupational Medicine and Industrial Hygiene, National Taiwan
      University College of Public Health, Taipei, Taiwan. pchen@ntu.edu.tw.
FAU - Hsieh, Wu-Shiun
AU  - Hsieh WS
FAU - Su, Yi-Ning
AU  - Su YN
FAU - Liao, Hua-Fang
AU  - Liao HF
FAU - Jeng, Suh-Fang
AU  - Jeng SF
FAU - Taso, Feng-Ming
AU  - Taso FM
FAU - Hwang, Yaw-Huei
AU  - Hwang YH
FAU - Wu, Kuen-Yuh
AU  - Wu KY
FAU - Chen, Chia-Yang
AU  - Chen CY
FAU - Guo, Yueliang Leon
AU  - Guo YL
FAU - Chen, Pau-Chung
AU  - Chen PC
LA  - eng
PT  - Journal Article
DEP - 20110812
PL  - England
TA  - BMC Res Notes
JT  - BMC research notes
JID - 101462768
PMC - PMC3170609
EDAT- 2011/08/16 06:00
MHDA- 2011/08/16 06:01
CRDT- 2011/08/16 06:00
PHST- 2011/04/13 00:00 [received]
PHST- 2011/08/12 00:00 [accepted]
PHST- 2011/08/16 06:00 [entrez]
PHST- 2011/08/16 06:00 [pubmed]
PHST- 2011/08/16 06:01 [medline]
AID - 1756-0500-4-291 [pii]
AID - 10.1186/1756-0500-4-291 [doi]
PST - epublish
SO  - BMC Res Notes. 2011 Aug 12;4:291. doi: 10.1186/1756-0500-4-291.


PMID- 21838861
OWN - NLM
STAT- MEDLINE
DCOM- 20111213
LR  - 20211020
IS  - 1471-227X (Electronic)
IS  - 1471-227X (Linking)
VI  - 11
DP  - 2011 Aug 12
TI  - Withholding and withdrawing life-sustaining therapy in a Moroccan Emergency
      Department: an observational study.
PG  - 12
LID - 10.1186/1471-227X-11-12 [doi]
AB  - BACKGROUND: Withdrawing and withholding life-support therapy (WH/WD) are
      undeniably integrated parts of medical activity. However, Emergency Department
      (ED) might not be the most appropriate place to give end-of life (EOL) care; the 
      legal aspects and practices of the EOL care in emergency rooms are rarely
      mentioned in the medical literature and should be studied. The aims of this study
      were to assess frequency of situations where life-support therapies were withheld
      or withdrawn and modalities for implement of these decisions. METHOD: A survey of
      patients who died in a Moroccan ED was performed. Confounding variables examined 
      were: Age, gender, chronic underlying diseases, acute medical disorders, APACHE
      II score, Charlson Comorbidities Index, and Length of stay. If a decision of
      WH/WD was taken, additional data were collected: Type of decision; reasons
      supporting the decision, modalities of WH/WD, moment, time from ED admission to
      decision, and time from processing to withhold or withdrawal life-sustaining
      treatment to death. Individuals who initiated (single emergency physician,
      medical staff), and were involved in the decision (nursing staff, patients, and
      families), and documentation of the decision in the medical record. RESULTS: 177 
      patients who died in ED between November 2009 and March 2010 were included.
      Withholding and withdrawing life-sustaining treatment was applied to 30.5% of all
      patients who died. Therapies were withheld in 24.2% and were withdrawn in 6.2%.
      The most reasons for making these decisions were; absence of improvement
      following a period of active treatment (61.1%), and expected irreversibility of
      acute disorder in the first 24 h (42.6%). The most common modalities withheld or 
      withdrawn life-support therapy were mechanical ventilation (17%), vasopressor and
      inotrops infusion (15.8%). Factors associated with WH/WD decisions were older age
      (OR = 1.1; 95%IC = 1.01-1.07; P = 0.001), neurological acute medical disorders
      (OR = 4.1; 95%IC = 1.48-11.68; P = 0.007), malignancy (OR = 7.7; 95%IC =
      1.38-8.54; P = 0.002) and cardiovascular (OR = 3.4;95%IC = 2.06-28.5;P = 0.008)
      chronic underlying diseases. CONCLUSION: Life-sustaining treatment were
      frequently withheld or withdrawn from elderly patients with underlying chronic
      cardiovascular disease or metastatic cancer or patients with acute neurological
      medical disorders in a Moroccan ED. Religious beliefs and the lack of guidelines 
      and official Moroccan laws could explain the ethical limitations of the
      decision-making process recorded in this study.
FAU - Damghi, Nada
AU  - Damghi N
AD  - Medical Emergency Department, Ibn Sina University Hospital, 10000, Rabat,
      Morocco.
FAU - Belayachi, Jihane
AU  - Belayachi J
FAU - Aggoug, Badria
AU  - Aggoug B
FAU - Dendane, Tarek
AU  - Dendane T
FAU - Abidi, Khalid
AU  - Abidi K
FAU - Madani, Naoufel
AU  - Madani N
FAU - Zekraoui, Aicha
AU  - Zekraoui A
FAU - Belabes, Abdellatif Benchekroun
AU  - Belabes AB
FAU - Zeggwagh, Amine Ali
AU  - Zeggwagh AA
FAU - Abouqal, Redouane
AU  - Abouqal R
LA  - eng
PT  - Journal Article
DEP - 20110812
PL  - England
TA  - BMC Emerg Med
JT  - BMC emergency medicine
JID - 100968543
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Decision Making
MH  - Emergencies/*epidemiology
MH  - Emergency Service, Hospital/*statistics & numerical data
MH  - Female
MH  - Humans
MH  - Life Support Care/*statistics & numerical data
MH  - Male
MH  - Middle Aged
MH  - Morocco/epidemiology
MH  - Retrospective Studies
MH  - Young Adult
PMC - PMC3199862
EDAT- 2011/08/16 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/08/16 06:00
PHST- 2011/03/03 00:00 [received]
PHST- 2011/08/12 00:00 [accepted]
PHST- 2011/08/16 06:00 [entrez]
PHST- 2011/08/16 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 1471-227X-11-12 [pii]
AID - 10.1186/1471-227X-11-12 [doi]
PST - epublish
SO  - BMC Emerg Med. 2011 Aug 12;11:12. doi: 10.1186/1471-227X-11-12.


PMID- 21838829
OWN - NLM
STAT- MEDLINE
DCOM- 20140403
LR  - 20211020
IS  - 1369-7625 (Electronic)
IS  - 1369-6513 (Linking)
VI  - 16
IP  - 3
DP  - 2013 Sep
TI  - Parental views on informed consent for expanded newborn screening.
PG  - 239-50
LID - 10.1111/j.1369-7625.2011.00710.x [doi]
AB  - BACKGROUND: An increasing array of rare inherited conditions can be detected as
      part of the universal newborn screening programme. The introduction and
      evaluation of these service developments require consideration of the ethical
      issues involved and appropriate mechanisms for informing parents and gaining
      consent if required. Exploration of parental views is needed to inform the debate
      and specifically consider whether more flexible protocols are needed to fit with 
      the public perception of new developments in this context. OBJECTIVE: This study 
      has been undertaken to explore perceptions and attitudes of parents and future
      parents to an expanded newborn screening programme in the United Kingdom and the 
      necessary information provision and consent processes. DESIGN AND PARTICIPANTS: A
      mixed methods study involving focus groups (n = 29) and a web-survey (n = 142)
      undertaken with parents and future parents. RESULTS AND CONCLUSIONS: Parents want
      guaranteed information provision with clear decision-making powers and an
      awareness of the choices available to them. The difference between existing
      screening provision and expanded screening was not considered to be significant
      enough by participants to warrant formal written, informed consent for expanded
      screening. It is argued that the ethical review processes need to be more
      flexible towards the provision of information and consent processes for service
      developments in newborn screening.
CI  - (c) 2011 John Wiley & Sons Ltd.
FAU - Moody, Louise
AU  - Moody L
AD  - Department of Industrial Design, Coventry University, UK. L.moody@coventry.ac.uk
FAU - Choudhry, Kubra
AU  - Choudhry K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110812
PL  - England
TA  - Health Expect
JT  - Health expectations : an international journal of public participation in health 
      care and health policy
JID - 9815926
SB  - IM
MH  - Data Collection
MH  - Decision Making
MH  - Female
MH  - Focus Groups
MH  - Humans
MH  - Infant, Newborn
MH  - Informed Consent/ethics/*psychology
MH  - Male
MH  - Neonatal Screening/ethics/*psychology
MH  - Parents/*psychology
MH  - Patient Acceptance of Health Care/psychology
MH  - United Kingdom
PMC - PMC5060664
OTO - NOTNLM
OT  - expanded newborn screening
OT  - heel-prick test
OT  - informed consent
EDAT- 2011/08/16 06:00
MHDA- 2014/04/04 06:00
CRDT- 2011/08/16 06:00
PHST- 2011/08/16 06:00 [entrez]
PHST- 2011/08/16 06:00 [pubmed]
PHST- 2014/04/04 06:00 [medline]
AID - 10.1111/j.1369-7625.2011.00710.x [doi]
PST - ppublish
SO  - Health Expect. 2013 Sep;16(3):239-50. doi: 10.1111/j.1369-7625.2011.00710.x. Epub
      2011 Aug 12.


PMID- 21838118
OWN - NLM
STAT- MEDLINE
DCOM- 20110906
LR  - 20110815
IS  - 0882-1577 (Print)
IS  - 0882-1577 (Linking)
VI  - 92
IP  - 4
DP  - 2011 Jul-Aug
TI  - Ethical perspective on health care reform.
PG  - 81
FAU - Hamel, Ron
AU  - Hamel R
LA  - eng
PT  - Introductory Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Health Prog
JT  - Health progress (Saint Louis, Mo.)
JID - 8500263
MH  - Catholicism
MH  - Health Care Reform/*ethics
MH  - Humans
MH  - United States
EDAT- 2011/08/16 06:00
MHDA- 2011/09/07 06:00
CRDT- 2011/08/16 06:00
PHST- 2011/08/16 06:00 [entrez]
PHST- 2011/08/16 06:00 [pubmed]
PHST- 2011/09/07 06:00 [medline]
PST - ppublish
SO  - Health Prog. 2011 Jul-Aug;92(4):81.


PMID- 21837895
OWN - NLM
STAT- MEDLINE
DCOM- 20110901
LR  - 20110815
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 22
IP  - 2
DP  - 2011 Summer
TI  - Certifying clinical ethics consultants: who pays?
PG  - 194-9
AB  - The movement advocating the formal certification of clinical ethics consultants
      may result in major changes to the field of clinical ethics consultation by
      creating a new standard of care. The actual certification process is still in the
      development phase, but unanswered questions include: What will certification
      cost, and, Who will pay? Currently there is little salary support for ethics
      consultants and no regulation requiring healthcare institutions to offer clinical
      ethics consultation. Without the support of healthcare administrators and
      accreditation bodies, this may remain unchanged. Healthcare administrators may be
      unwilling to pay for certification or professional services if accreditation
      bodies do not require healthcare institutions to provide certified ethics
      consultants' services. If consultants will not be reimbursed or paid, they may
      not seek certification. If certified consultants are required, healthcare
      administrators may look for ways to cover the costs for providing this service,
      including insurance or third-party reimbursement and direct billing of patients
      for consultations, which may affect who performs and who participates in ethics
      consultation. However, this is less than ideal, as bioethicists believe ethics
      consultation should be available to all as part of providing safe, quality
      ethical care and support and guidance for patients, families, and healthcare
      staff. Going forward, bioethicists should study quality improvement, patient
      safety, and cost-savings resulting from certification-eligible clinical ethics
      consultants' activities. Administrators and financial personnel can be surveyed
      regarding their support for the certification process. Bioethicists should enlist
      the help of patient rights and safety advocacy groups, professional medical
      associations, and healthcare administrators. Bioethicists should invite
      accreditation bodies, healthcare administrators, and financial personnel to
      collaborate in the development of the certification process. Without their
      support, certification may be of value only to the bioethics community, and may
      have little standing in actual clinical healthcare institution settings.
FAU - Burda, Marianne
AU  - Burda M
AD  - burdam@duq.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
MH  - *Certification/economics
MH  - *Consultants
MH  - *Ethicists/education
MH  - *Ethics, Clinical
MH  - Hospital Administrators
MH  - Humans
MH  - Insurance, Health, Reimbursement
MH  - Professional Competence/*economics/standards
MH  - Quality Improvement
MH  - Salaries and Fringe Benefits
MH  - Standard of Care/*economics
MH  - United States
EDAT- 2011/08/16 06:00
MHDA- 2011/09/02 06:00
CRDT- 2011/08/16 06:00
PHST- 2011/08/16 06:00 [entrez]
PHST- 2011/08/16 06:00 [pubmed]
PHST- 2011/09/02 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2011 Summer;22(2):194-9.


PMID- 21837893
OWN - NLM
STAT- MEDLINE
DCOM- 20110901
LR  - 20110815
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 22
IP  - 2
DP  - 2011 Summer
TI  - Physician, monitor thyself: professionalism and accountability in the use of
      social media.
PG  - 187-90
AB  - The recent report of the AMA Council on Ethical and Judicial Affairs (CEJA),
      "Professionalism in the Use of Social Media," describes the types of social media
      medical professionals use, outlines ways in which existing AMA policies address
      issues of online professionalism, and makes a list of recommendations for
      physicians to maintain online professionalism. CEJA recommends directed efforts
      towards educating physicians about the benefits and pitfalls of social media and,
      in particular, underscores the difficulties of maintaining professional
      boundaries in the digital age. In this commentary, we highlight issues introduced
      by the report and suggest some specific ways that the recommendations of the
      committee can be implemented by medical schools, residency programs, and
      practicing physicians.
FAU - Lagu, Tara
AU  - Lagu T
AD  - Center for Quality of Care Research, Baystate Medical Center, Division of General
      Internal Medicine, Boston, USA. Tara.Lagu@baystatehealth.org
FAU - Greysen, S Ryan
AU  - Greysen SR
LA  - eng
PT  - Comment
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
CON - J Clin Ethics. 2011 Summer;22(2):165-72. PMID: 21837888
CIN - J Clin Ethics. 2011 Summer;22(2):191-3. PMID: 21837894
MH  - Advisory Committees
MH  - American Medical Association
MH  - Ethics, Medical
MH  - *Guideline Adherence
MH  - Guidelines as Topic
MH  - Humans
MH  - *Internet/ethics
MH  - *Liability, Legal
MH  - Physician-Patient Relations/ethics
MH  - Physicians/*ethics/standards
MH  - *Privacy
MH  - *Social Environment
MH  - *Social Responsibility
MH  - United States
EDAT- 2011/08/16 06:00
MHDA- 2011/09/02 06:00
CRDT- 2011/08/16 06:00
PHST- 2011/08/16 06:00 [entrez]
PHST- 2011/08/16 06:00 [pubmed]
PHST- 2011/09/02 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2011 Summer;22(2):187-90.


PMID- 21837892
OWN - NLM
STAT- MEDLINE
DCOM- 20110901
LR  - 20151119
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 22
IP  - 2
DP  - 2011 Summer
TI  - Blurring boundaries and online opportunities.
PG  - 183-6
AB  - The rising use of social media, for both clinical and nonclinical purposes,
      obviates the need for policy to more explicitly guide physicians, and their
      behaviors, in this new digital environment.The current report from the AMA
      Council on Ethical and Judicial Affairs (CEJA) addresses a number of these
      issues, specifically the nature of interaction and representation between
      physicians and patients. However, given the nature of the focus of this
      report-the nonclinical use of the internet and social media-there are a number of
      issues that deserve attention, in particular encouraging education and addressing
      how to approach relationships among medical professionals of varying levels of
      training.
FAU - Farnan, Jeanne M
AU  - Farnan JM
AD  - Section of Hospital Medicine, Department of Medicine, University of Chicago, USA.
      jfarnan@medicine.bsd.uchicago.edu
FAU - Arora, Vineet M
AU  - Arora VM
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
CON - J Clin Ethics. 2011 Summer;22(2):165-72. PMID: 21837888
CIN - J Clin Ethics. 2011 Summer;22(2):191-3. PMID: 21837894
MH  - Advisory Committees
MH  - American Medical Association
MH  - Education, Medical/trends
MH  - Ethics, Medical
MH  - Guideline Adherence
MH  - Humans
MH  - Internet/*ethics
MH  - Physician-Patient Relations/*ethics
MH  - Physicians/*ethics
MH  - Practice Patterns, Physicians'/*ethics
MH  - *Privacy
MH  - Social Environment
MH  - Trust
MH  - United States
EDAT- 2011/08/16 06:00
MHDA- 2011/09/02 06:00
CRDT- 2011/08/16 06:00
PHST- 2011/08/16 06:00 [entrez]
PHST- 2011/08/16 06:00 [pubmed]
PHST- 2011/09/02 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2011 Summer;22(2):183-6.


PMID- 21837891
OWN - NLM
STAT- MEDLINE
DCOM- 20110901
LR  - 20151119
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 22
IP  - 2
DP  - 2011 Summer
TI  - Nonclinical use of online social networking sites: new and old challenges to
      medical professionalism.
PG  - 179-82
AB  - The AMA Council on Ethical and Judicial Affairs (CEJA) has written a position
      paper on how social medical use challenges medical professionalism. The report
      offers persuasive ethical and practical guidelines for nonclinical internet use, 
      specifically for social networking. This commentary provides a framework from
      which to apply these guidelines, but adds that there may be important situations 
      in which physicians are not able to act in accordance. The guidelines call for
      professional reporting of questionable online portrayals or behaviors, but this
      commentary argues that this may be not only cumbersome to implement, but may
      violate aspects of constitutional rights. While online social networking may in
      many ways be a new application of old challenges, there may be other aspects that
      require novel approaches to medical professionalism.
FAU - Thompson, Lindsay A
AU  - Thompson LA
AD  - College of Medicine, University of Florida, Gainesville, USA.
      lathompson@peds.ufl.edu
FAU - Black, Erik W
AU  - Black EW
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
CON - J Clin Ethics. 2011 Summer;22(2):165-72. PMID: 21837888
CIN - J Clin Ethics. 2011 Summer;22(2):191-3. PMID: 21837894
MH  - Advisory Committees
MH  - American Medical Association
MH  - California
MH  - Ethics, Medical
MH  - Guideline Adherence
MH  - Humans
MH  - Internet/*ethics
MH  - Liability, Legal
MH  - Physician-Patient Relations/ethics
MH  - Physicians/*ethics/*legislation & jurisprudence
MH  - Practice Patterns, Physicians'/*ethics
MH  - Privacy/*legislation & jurisprudence
MH  - *Social Environment
MH  - United States
EDAT- 2011/08/16 06:00
MHDA- 2011/09/02 06:00
CRDT- 2011/08/16 06:00
PHST- 2011/08/16 06:00 [entrez]
PHST- 2011/08/16 06:00 [pubmed]
PHST- 2011/09/02 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2011 Summer;22(2):179-82.


PMID- 21837889
OWN - NLM
STAT- MEDLINE
DCOM- 20110901
LR  - 20151119
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 22
IP  - 2
DP  - 2011 Summer
TI  - Online professionalism: social media, social contracts, trust, and medicine.
PG  - 173-5
AB  - The AMA Council on Ethical and Judicial Affairs (CEJA) has initiated an important
      discussion on medical professionalism and the use of social media by issuing
      thoughtful and practical guidance for physicians and medical students. The
      implications of online activities for trust in the profession, as well as for
      trust between patient and doctor, however, will need further exploration as
      digital life expands and evolves.
FAU - Snyder, Lois
AU  - Snyder L
AD  - Center for Ethics and Professionalism, American College of Physicians,
      Philadelphia, USA. Isnyder@acponline.org
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
CON - J Clin Ethics. 2011 Summer;22(2):165-72. PMID: 21837888
CIN - J Clin Ethics. 2011 Summer;22(2):191-3. PMID: 21837894
MH  - Advisory Committees
MH  - American Medical Association
MH  - Ethics, Medical
MH  - Guideline Adherence
MH  - Humans
MH  - *Internet/ethics
MH  - Liability, Legal
MH  - Personal Autonomy
MH  - Physician-Patient Relations/*ethics
MH  - Physicians/*ethics
MH  - Practice Patterns, Physicians'/*ethics
MH  - Professional Autonomy
MH  - *Social Environment
MH  - *Trust
MH  - United States
EDAT- 2011/08/16 06:00
MHDA- 2011/09/02 06:00
CRDT- 2011/08/16 06:00
PHST- 2011/08/16 06:00 [entrez]
PHST- 2011/08/16 06:00 [pubmed]
PHST- 2011/09/02 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2011 Summer;22(2):173-5.


PMID- 21837888
OWN - NLM
STAT- MEDLINE
DCOM- 20110901
LR  - 20220310
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 22
IP  - 2
DP  - 2011 Summer
TI  - Report of the AMA Council on Ethical and Judicial Affairs: professionalism in the
      use of social media.
PG  - 165-72
AB  - Although many physicians have been using the internet for both clinical and
      social purposes for years, recently concerns have been raised regarding blurred
      boundaries of the profession as a whole. In both the news media and medical
      literature, physicians have noted there are unanswered questions in these areas, 
      and that professional self-regulation is needed. This report discusses the
      ethical implications of physicians' nonclinical use of the internet, including
      the use of social networking sites, blogs, and other means to post content
      online. It does not address the clinical use of the internet, such as
      telemedicine, e-prescribing, online clinical consultations, health-related
      websites, use of electronic media for clinical collaboration, and e-mailing
      patients (some of which are already covered in the AMA's Code of Medical Ethics).
FAU - Shore, Rebecca
AU  - Shore R
AD  - American Medical Association, Chicago, USA. Rebecca.Shore@ama-assn.org
FAU - Halsey, Julia
AU  - Halsey J
FAU - Shah, Kavita
AU  - Shah K
FAU - Crigger, Bette-Jane
AU  - Crigger BJ
FAU - Douglas, Sharon P
AU  - Douglas SP
CN  - AMA Council on Ethical and Judicial Affairs (CEJA)
LA  - eng
PT  - Guideline
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
CIN - J Clin Ethics. 2011 Summer;22(2):173-5. PMID: 21837889
CIN - J Clin Ethics. 2011 Summer;22(2):176-8. PMID: 21837890
CIN - J Clin Ethics. 2011 Summer;22(2):179-82. PMID: 21837891
CIN - J Clin Ethics. 2011 Summer;22(2):183-6. PMID: 21837892
CIN - J Clin Ethics. 2011 Summer;22(2):187-90. PMID: 21837893
CIN - J Clin Ethics. 2011 Summer;22(2):191-3. PMID: 21837894
MH  - Advisory Committees
MH  - American Medical Association
MH  - Ethical Analysis
MH  - Ethics, Medical
MH  - Humans
MH  - *Internet/ethics
MH  - Liability, Legal
MH  - *Personal Autonomy
MH  - Physician-Patient Relations/*ethics
MH  - Physicians/*ethics/legislation & jurisprudence
MH  - Practice Patterns, Physicians'/*ethics
MH  - Privacy
MH  - Professional Autonomy
MH  - *Social Environment
MH  - Trust
MH  - United States
EDAT- 2011/08/16 06:00
MHDA- 2011/09/02 06:00
CRDT- 2011/08/16 06:00
PHST- 2011/08/16 06:00 [entrez]
PHST- 2011/08/16 06:00 [pubmed]
PHST- 2011/09/02 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2011 Summer;22(2):165-72.


PMID- 21837887
OWN - NLM
STAT- MEDLINE
DCOM- 20110901
LR  - 20110815
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 22
IP  - 2
DP  - 2011 Summer
TI  - A systematic review of activities at a high-volume ethics consultation service.
PG  - 151-64
AB  - We describe the ethics consultation service (ECS) at the Cleveland Clinic and
      report on its activities over a 24-month period in which 478 consultations were
      performed.To our knowledge, this is the largest case series of ethics
      consultations reported to date. Established more than 25 years ago, the ECS at
      the Cleveland Clinic is staffed by multiple consultants with advanced training in
      bioethics. Several of these ethicists work closely with specialized clinical
      units and research departments, where they participate in multidisciplinary
      meetings and provide specialized assistance. This combination of historical
      experience, large numbers of consultation requests, and specialized clinical
      ethicists suggests that the experience at the Cleveland Clinic may be helpful to 
      ethicists and others who may be considering how to structure and sustain a
      vibrant ECS. Our results highlight the diversity of activities performed by a
      high-volume ECS at a tertiary care facility. Our hope in sharing the inner
      workings of the ECS at the Cleveland Clinic is to promote dialogue on common
      practices and approaches across medical institutions that support ethics
      consultation.
FAU - Bruce, Courtenay R
AU  - Bruce CR
AD  - Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston,
      Texas, USA.
FAU - Smith, Martin L
AU  - Smith ML
FAU - Hizlan, Sabahat
AU  - Hizlan S
FAU - Sharp, Richard R
AU  - Sharp RR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
MH  - *Ambulatory Care Facilities/organization & administration
MH  - Bioethical Issues
MH  - Ethics Consultation/*organization & administration
MH  - Ethics, Medical
MH  - Forms and Records Control
MH  - Humans
MH  - Ohio
MH  - Research Design
EDAT- 2011/08/16 06:00
MHDA- 2011/09/02 06:00
CRDT- 2011/08/16 06:00
PHST- 2011/08/16 06:00 [entrez]
PHST- 2011/08/16 06:00 [pubmed]
PHST- 2011/09/02 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2011 Summer;22(2):151-64.


PMID- 21837884
OWN - NLM
STAT- MEDLINE
DCOM- 20110901
LR  - 20110815
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 22
IP  - 2
DP  - 2011 Summer
TI  - Revisiting the best interest standard: uses and misuses.
PG  - 128-33
AB  - The best interest standard is the threshold most frequently employed by
      physicians and ethics consultants in challenging a parent's refusal to provide
      consent for a child's medical care. In this article, I will argue that the best
      interest standard has evolved to serve two different functions, and that these
      functions differ sufficiently that they require separate standards. While the
      best interest standard is appropriate for choosing among alternative treatment
      options for children, making recommendations to parents, and making decisions on 
      behalf of a child when the legal decision makers are either unable to make a
      decision or are in dispute, a different standard is required for deciding when to
      seek state interference with parental decision-making authority. I will suggest
      that the harm principle provides a more appropriate threshold for determining
      when to seek state intervention than the best interest standard.
FAU - Diekema, Douglas S
AU  - Diekema DS
AD  - Treuman Katz Center for Pediatric Bioethics, Seattle Children's Research
      Institute, Seattle, USA. diek@u.washington.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
RN  - 0 (Tetanus Toxoid)
SB  - IM
CIN - J Clin Ethics. 2011 Summer;22(2):134-8. PMID: 21837885
MH  - Adult
MH  - Child
MH  - Decision Making/*ethics
MH  - Humans
MH  - Parental Consent/*ethics/legislation & jurisprudence
MH  - *Patient Advocacy/ethics/legislation & jurisprudence/standards
MH  - Tetanus/etiology/prevention & control
MH  - Tetanus Toxoid/administration & dosage
MH  - Treatment Refusal/*ethics/legislation & jurisprudence
MH  - United States
MH  - Wounds, Penetrating/complications
EDAT- 2011/08/16 06:00
MHDA- 2011/09/02 06:00
CRDT- 2011/08/16 06:00
PHST- 2011/08/16 06:00 [entrez]
PHST- 2011/08/16 06:00 [pubmed]
PHST- 2011/09/02 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2011 Summer;22(2):128-33.


PMID- 21837883
OWN - NLM
STAT- MEDLINE
DCOM- 20110901
LR  - 20191210
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 22
IP  - 2
DP  - 2011 Summer
TI  - Trusting families: Responding to Mary Ann Meeker, "Responsive care management:
      family decision makers in advanced cancer".
PG  - 123-7
AB  - Mary Ann Meeker's article admirably reminds readers that family members are
      involved in--or "responsively manage"--the care of relatives with severe illness 
      in ways that run considerably beyond the stereotypes at play in many bioethical
      discussions of advance directives. Her observations thus make thinking about the 
      role of families in healthcare provision more adequate to the facts, and this is 
      an important contribution. There's reason to be worried, however, that one
      explicit aim of the article--to ease the standing anxieties that many clinicians 
      and ethicists have about the reliability of family members as proxy decision
      makers--will be frustrated by its very success. Those already inclined to
      suspicion may tend to think that the more intricate and pervasive the ways in
      which families influence the healthcare decision making of their sick, the more
      chances they have for altering the connection between patients' interests and the
      actions of professional providers. To determine whether and when such alterations
      are something to be concerned about, we'll need to supplement a better grasp of
      the pertinent facts with a deeper sense of how human agency works and why we
      value it. We may also need some reminders about the defensibility of diverse
      moral understandings. Although both professionals and family members may profess 
      an ethic that sets patients' interests above those of non-patients--as Meeker's
      own results suggest--any strict allegiance to such a framework may be more
      notional than normative--as her findings also hint. The actual working norms
      (among professionals, as well as within families) will likely be more complex,
      but not necessarily any the less defensible for that.
FAU - Nelson, James Lindemann
AU  - Nelson JL
AD  - College of Arts and Letters, Center for Ethics and Humanities in the Life
      Sciences, Michigan State University, East Lansing, USA. jlnelson@msu.edu
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
CON - J Clin Ethics. 2011 Summer;22(2):107-22. PMID: 21837882
CIN - J Clin Ethics. 2011 Summer;22(2):99-106. PMID: 21837881
MH  - *Conflict of Interest
MH  - Conflict, Psychological
MH  - Decision Making/*ethics
MH  - *Family
MH  - Family Relations
MH  - Humans
MH  - *Neoplasms/psychology/therapy
MH  - *Patient Advocacy
MH  - Personal Autonomy
MH  - Trust
EDAT- 2011/08/16 06:00
MHDA- 2011/09/02 06:00
CRDT- 2011/08/16 06:00
PHST- 2011/08/16 06:00 [entrez]
PHST- 2011/08/16 06:00 [pubmed]
PHST- 2011/09/02 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2011 Summer;22(2):123-7.


PMID- 21837544
OWN - NLM
STAT- MEDLINE
DCOM- 20120208
LR  - 20141120
IS  - 1572-8633 (Electronic)
IS  - 1386-7423 (Linking)
VI  - 14
IP  - 4
DP  - 2011 Nov
TI  - Editorial for the thematic section "social responsibility and health".
PG  - 353-4
LID - 10.1007/s11019-011-9343-y [doi]
AB  - The contributions collected in this section deal with some of the most crucial
      issues addressed in the Report on "Social Responsibility and Health" of the
      International Bioethics Committee: the importance of 'social responsibility' in
      the promotion of health, i.e. far beyond the context of the ethics of management 
      and private companies where the term was introduced at first; the role of
      solidarity as a necessary presupposition for a genuinely universalistic morality 
      of justice; the content of the right to health care, especially when we consider 
      it as a 'legal' right; the quest for efficiency in health care policies, which is
      indispensable if we want to effectively extend the enjoyment of progressively
      higher standard of health; the sense of responsibility in the context of
      professional activities; the decision making procedures that are to be
      implemented in order to achieve a fair and just allocation of resources.
FAU - Semplici, Stefano
AU  - Semplici S
LA  - eng
PT  - Editorial
PL  - Netherlands
TA  - Med Health Care Philos
JT  - Medicine, health care, and philosophy
JID - 9815900
SB  - IM
MH  - *Bioethics
MH  - Delivery of Health Care/*ethics
MH  - Global Health
MH  - Health Promotion/*ethics
MH  - *Human Rights
MH  - Humans
MH  - *Social Responsibility
MH  - United Nations
EDAT- 2011/08/13 06:00
MHDA- 2012/02/09 06:00
CRDT- 2011/08/13 06:00
PHST- 2011/08/13 06:00 [entrez]
PHST- 2011/08/13 06:00 [pubmed]
PHST- 2012/02/09 06:00 [medline]
AID - 10.1007/s11019-011-9343-y [doi]
PST - ppublish
SO  - Med Health Care Philos. 2011 Nov;14(4):353-4. doi: 10.1007/s11019-011-9343-y.


PMID- 21836638
OWN - NLM
STAT- MEDLINE
DCOM- 20120222
LR  - 20211020
IS  - 1469-3178 (Electronic)
IS  - 1469-221X (Linking)
VI  - 12
IP  - 9
DP  - 2011 Sep 1
TI  - The ethics of collaborative authorship. More realistic standards and better
      accountability are needed to enhance scientific publication and give credit where
      it is due.
PG  - 889-93
LID - 10.1038/embor.2011.161 [doi]
FAU - Teixeira da Silva, Jaime A
AU  - Teixeira da Silva JA
AD  - Faculty of Agriculture and Graduate School of Agriculture, Kagawa University,
      Japan. jaimetex@yahoo.com
LA  - eng
PT  - Journal Article
DEP - 20110901
PL  - England
TA  - EMBO Rep
JT  - EMBO reports
JID - 100963049
SB  - IM
MH  - Authorship/*standards
MH  - *Cooperative Behavior
MH  - Humans
MH  - Publishing/*ethics/*standards
MH  - Research
MH  - Research Report
PMC - PMC3166465
EDAT- 2011/08/13 06:00
MHDA- 2012/02/23 06:00
CRDT- 2011/08/13 06:00
PHST- 2011/04/09 00:00 [received]
PHST- 2011/07/13 00:00 [accepted]
PHST- 2011/08/13 06:00 [entrez]
PHST- 2011/08/13 06:00 [pubmed]
PHST- 2012/02/23 06:00 [medline]
AID - embor2011161 [pii]
AID - 10.1038/embor.2011.161 [doi]
PST - epublish
SO  - EMBO Rep. 2011 Sep 1;12(9):889-93. doi: 10.1038/embor.2011.161.


PMID- 21836551
OWN - NLM
STAT- MEDLINE
DCOM- 20111228
LR  - 20161125
IS  - 1476-5373 (Electronic)
IS  - 0007-0610 (Linking)
VI  - 211
IP  - 3
DP  - 2011 Aug 12
TI  - An audit of dental prescriptions between clinics and dental laboratories.
PG  - E5
LID - 10.1038/sj.bdj.2011.623 [doi]
AB  - AIM: To discover the quality of written instructions from dentists to dental
      technicians and the nature of non-compliant prescriptions. METHOD: An audit of
      laboratory prescription compliance was conducted within an NHS Trust Dental
      Teaching Hospital to determine the level of communication between dentists and
      dental technicians. One hundred and fifty prescriptions were audited from dental 
      undergraduates and qualified dentists throughout the different departments.
      RESULTS: A total of two-thirds of prescriptions were considered non-compliant and
      failed to meet relevant ethical and legal guidelines. This problem was seen
      throughout all departments and at all professional levels. CONCLUSION: A
      breakdown in communication between dentists and technicians through the use of
      prescriptions is evident even within a close working environment.
FAU - Stewart, C A
AU  - Stewart CA
AD  - Cardiff and Vale University Health Board, University Dental Hospital, Heath Park,
      Cardiff, CF14 4XY. ceri_stewart@hotmail.co.uk
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110812
PL  - England
TA  - Br Dent J
JT  - British dental journal
JID - 7513219
SB  - IM
CIN - Br Dent J. 2011 Aug;211(3):126-7. PMID: 21836581
MH  - Adult
MH  - Communication
MH  - Dental Audit
MH  - Dental Prosthesis Design/*standards
MH  - *Dental Technicians
MH  - *Dentists
MH  - Humans
MH  - Interprofessional Relations/ethics
MH  - Middle Aged
MH  - Orthodontic Appliance Design/standards
MH  - Orthodontics/education/instrumentation/standards
MH  - Prescriptions/*standards
MH  - Prosthodontics/education/instrumentation/standards
MH  - Technology, Dental/education/legislation & jurisprudence/*standards
MH  - United Kingdom
EDAT- 2011/08/13 06:00
MHDA- 2011/12/29 06:00
CRDT- 2011/08/13 06:00
PHST- 2011/03/04 00:00 [accepted]
PHST- 2011/08/13 06:00 [entrez]
PHST- 2011/08/13 06:00 [pubmed]
PHST- 2011/12/29 06:00 [medline]
AID - sj.bdj.2011.623 [pii]
AID - 10.1038/sj.bdj.2011.623 [doi]
PST - epublish
SO  - Br Dent J. 2011 Aug 12;211(3):E5. doi: 10.1038/sj.bdj.2011.623.


PMID- 21836525
OWN - NLM
STAT- MEDLINE
DCOM- 20120111
LR  - 20191210
IS  - 1536-7312 (Electronic)
IS  - 0196-206X (Linking)
VI  - 32
IP  - 7
DP  - 2011 Sep
TI  - An ethical conflict between parents and clinician in a child with a language
      delay.
PG  - 559-60
LID - 10.1097/DBP.0b013e31822bc5fe [doi]
AB  - CASE: A developmental-behavioral pediatrician evaluated a 2-year-old child for
      developmental delays. He determined that the child had mild expressive language
      delays; the child had an intelligible vocabulary of 20 words and at least 20
      other words that he said unclearly. He said a few contracted 2-word phrases, such
      as "gimme" and "its ok." He was shy and generally clung to his parents who spoke 
      softly and very little. His development in all other domains was normal. Hearing 
      evaluation and the neurological examination were normal. The pediatrician
      provided suggestions to the parents in order to stimulate language and scheduled 
      a follow-up appointment in 3 months. The parents asked him to refer the child for
      early intervention and write a letter to the US Immigration and Naturalization
      Service. They asked that the letter state that the child had a disabling
      condition and returning the child and his family to their country of origin would
      cause permanent harm to the child. The parents then gave the pediatrician a draft
      of a letter that had been prepared by an immigration lawyer.The physician
      explained to the parents that the child had a mild expressive language delay and 
      that he would like to see the child again in 3 months before deciding on early
      intervention. He advised them to obtain a copy of his medical note from the
      medical records department. The parents insisted that he write the letter and got
      upset and called him "heartless" when the physician refused to write the letter.
FAU - Gupta, Vidya Bhushan
AU  - Gupta VB
AD  - New York Medical College, Valhalla, NY, USA.
FAU - Brosco, Jeffrey P
AU  - Brosco JP
FAU - Patel, Nidhip
AU  - Patel N
FAU - Braddock, Adam
AU  - Braddock A
FAU - Stein, Martin T
AU  - Stein MT
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Dev Behav Pediatr
JT  - Journal of developmental and behavioral pediatrics : JDBP
JID - 8006933
SB  - IM
MH  - Child, Preschool
MH  - Early Intervention, Educational
MH  - Emigrants and Immigrants/*legislation & jurisprudence/psychology
MH  - Humans
MH  - Language Development Disorders/*diagnosis/therapy
MH  - Parents/*psychology
MH  - Physician-Patient Relations/*ethics
MH  - Physicians/*ethics/psychology
MH  - Severity of Illness Index
EDAT- 2011/08/13 06:00
MHDA- 2012/01/12 06:00
CRDT- 2011/08/13 06:00
PHST- 2011/08/13 06:00 [entrez]
PHST- 2011/08/13 06:00 [pubmed]
PHST- 2012/01/12 06:00 [medline]
AID - 10.1097/DBP.0b013e31822bc5fe [doi]
PST - ppublish
SO  - J Dev Behav Pediatr. 2011 Sep;32(7):559-60. doi: 10.1097/DBP.0b013e31822bc5fe.


PMID- 21836120
OWN - NLM
STAT- MEDLINE
DCOM- 20120117
LR  - 20211020
IS  - 1541-0048 (Electronic)
IS  - 0090-0036 (Linking)
VI  - 101 Suppl 1
DP  - 2011 Dec
TI  - Ethical issues in using children's blood lead levels as a remedial action
      objective.
PG  - S156-60
LID - 10.2105/AJPH.2011.300226 [doi]
AB  - The Environmental Protection Agency measures the success or failure of Superfund 
      site remediation efforts against remedial action objectives (RAOs). RAOs are
      frequently based on environmental contaminant concentrations, but with lead
      exposure, blood lead levels from the population at risk are often used. Although 
      childhood lead screening is an important public health tool, an RAO based on
      child blood lead levels raises ethical concerns: public health efforts that are
      more reactive than preventive, a blood lead standard (10 mug/dL) that may not be 
      fully protective, the use of a measure whose validity and reliability may be
      easily compromised, and exacerbation of environmental injustice and systematic
      disadvantages. The example of Bunker Hill mine, Kellogg, Idaho, allowed an
      examination of these ethical concerns.
FAU - Moodie, Sue M
AU  - Moodie SM
AD  - Environmental Health Engineering, Johns Hopkins Bloomberg School of Public
      Health, Baltimore, MD, USA. moodie.sue@gmail.com
FAU - Evans, Emily Lorraine
AU  - Evans EL
LA  - eng
PT  - Journal Article
DEP - 20110811
PL  - United States
TA  - Am J Public Health
JT  - American journal of public health
JID - 1254074
RN  - 2P299V784P (Lead)
SB  - IM
CIN - Am J Public Health. 2012 Sep;102(9):e11; author reply e11-2. PMID: 22813473
MH  - Child
MH  - Child, Preschool
MH  - Environmental Monitoring/ethics
MH  - Environmental Restoration and Remediation/*ethics
MH  - Health Status Disparities
MH  - Humans
MH  - Idaho
MH  - Infant
MH  - Lead/*blood/toxicity
MH  - Lead Poisoning/*blood
MH  - Maximum Allowable Concentration
MH  - *Mining
MH  - Social Justice
MH  - United States
MH  - *United States Environmental Protection Agency
PMC - PMC3222472
EDAT- 2011/08/13 06:00
MHDA- 2012/01/18 06:00
CRDT- 2011/08/13 06:00
PHST- 2011/08/13 06:00 [entrez]
PHST- 2011/08/13 06:00 [pubmed]
PHST- 2012/01/18 06:00 [medline]
AID - AJPH.2011.300226 [pii]
AID - 10.2105/AJPH.2011.300226 [doi]
PST - ppublish
SO  - Am J Public Health. 2011 Dec;101 Suppl 1:S156-60. doi: 10.2105/AJPH.2011.300226. 
      Epub 2011 Aug 11.


PMID- 21835862
OWN - NLM
STAT- MEDLINE
DCOM- 20120223
LR  - 20211020
IS  - 1740-7753 (Electronic)
IS  - 1740-7745 (Linking)
VI  - 8
IP  - 4
DP  - 2011 Aug
TI  - Some essential considerations in the design and conduct of non-inferiority
      trials.
PG  - 432-9
LID - 10.1177/1740774511410994 [doi]
AB  - BACKGROUND: Suppose a standard therapy (Standard) has been established to provide
      a clinically important reduction in risk of irreversible morbidity or mortality. 
      In that setting, the safety and efficacy of an experimental intervention likely
      would be assessed in a clinical trial providing a comparison with Standard rather
      than a placebo arm. Such a trial often is designed to assess whether the efficacy
      of the experimental intervention is not unacceptably worse than that of Standard,
      and is called a non-inferiority trial. Formally, the non-inferiority trial
      usually is designed to rule out a non-inferiority margin, defined as the minimum 
      threshold for what would constitute an unacceptable loss of efficacy. PURPOSE:
      Even though the literature has many important articles identifying various
      approaches to the design and conduct of non-inferiority trials, confusion remains
      especially regarding key considerations for selecting the non-inferiority margin.
      The purpose of this article is to provide improved clarity regarding these
      considerations. METHODS: We present scientific insights into many factors that
      should be addressed in the design and conduct of non-inferiority trials to
      enhance their integrity and reliability, and provide motivation for key
      considerations that guide the selection of non-inferiority margins. We also
      provide illustrations and insights from recent experiences. RESULTS: Two
      considerations are essential, and should be addressed in separate steps, in the
      formulation of the non-inferiority margin. First, the margin should be formulated
      using adjustments to account for bias or lack of reliability in the estimate of
      the effect of Standard in the non-inferiority trial setting. Second, the
      non-inferiority margin should be formulated to achieve preservation of an
      appropriate percentage of the effect of Standard. LIMITATIONS: The
      considerations, in particular regarding the importance of preservation of effect,
      might not apply to settings where it would be ethical as well as clinically
      relevant to include both Standard and placebo arms in the trial for direct
      comparisons with the experimental intervention arm. CONCLUSIONS: Non-inferiority 
      trials with non-rigorous margins allow substantial risk for accepting
      inadequately effective experimental regimens, leading to the risk of erosion in
      quality of health care. The design and conduct of non-inferiority trials,
      including selection of non-inferiority margins, should account for many factors
      that can induce bias in the estimated effect of Standard in the non-inferiority
      trial and thus lead to bias in the estimated effect of the experimental
      treatment, for the need to ensure the experimental treatment preserves a
      clinically acceptable fraction of Standard's effect, and for the particular
      vulnerability of the integrity of a non-inferiority trial to the irregularities
      in trial conduct. Due to the inherent uncertainties in non-inferiority trials,
      alternative designs should be pursued whenever possible.
FAU - Fleming, Thomas R
AU  - Fleming TR
AD  - Department of Biostatistics, University of Washington, Seattle, WA 98195-7232,
      USA. tfleming@u.washington.edu
FAU - Odem-Davis, Katherine
AU  - Odem-Davis K
FAU - Rothmann, Mark D
AU  - Rothmann MD
FAU - Li Shen, Yuan
AU  - Li Shen Y
LA  - eng
GR  - R01 AI029168-23/AI/NIAID NIH HHS/United States
GR  - R37 AI 29168/AI/NIAID NIH HHS/United States
GR  - T32 AI007450/AI/NIAID NIH HHS/United States
GR  - R37 AI029168/AI/NIAID NIH HHS/United States
GR  - R01 AI029168/AI/NIAID NIH HHS/United States
GR  - T32 AI07450/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - Clin Trials
JT  - Clinical trials (London, England)
JID - 101197451
SB  - IM
MH  - Bias
MH  - Controlled Clinical Trials as Topic/*methods/statistics & numerical data
MH  - Effect Modifier, Epidemiologic
MH  - Quality Control
MH  - Randomized Controlled Trials as Topic
MH  - *Research Design/standards
MH  - Treatment Outcome
PMC - PMC3312046
MID - NIHMS362129
EDAT- 2011/08/13 06:00
MHDA- 2012/02/24 06:00
CRDT- 2011/08/13 06:00
PHST- 2011/08/13 06:00 [entrez]
PHST- 2011/08/13 06:00 [pubmed]
PHST- 2012/02/24 06:00 [medline]
AID - 8/4/432 [pii]
AID - 10.1177/1740774511410994 [doi]
PST - ppublish
SO  - Clin Trials. 2011 Aug;8(4):432-9. doi: 10.1177/1740774511410994.


PMID- 21835606
OWN - NLM
STAT- MEDLINE
DCOM- 20120209
LR  - 20111019
IS  - 1532-3374 (Electronic)
IS  - 0959-289X (Linking)
VI  - 20
IP  - 4
DP  - 2011 Oct
TI  - Assessment of coagulation in the obstetric population using ROTEM(R)
      thromboelastometry.
PG  - 293-8
LID - 10.1016/j.ijoa.2011.05.004 [doi]
AB  - BACKGROUND: Assessment of maternal coagulation to determine suitability for
      neuraxial anaesthesia and management of obstetric haemorrhage remains a
      challenge. Thromboelastography provides point of care patient assessment of the
      viscoelastic properties of whole blood clotting and can assist the clinician in
      haemostatic decision-making. The study aim was to determine the ROTEM(R)
      thromboelastometer 95% reference limits for third trimester parturients and to
      compare these with non-pregnant female controls. METHODS: Following ethics
      committee approval and informed consent, citrated blood was sampled from 120
      age-matched healthy pregnant and non-pregnant women. Thromboelastometry, using a 
      ROTEM(R) point of care monitor, was performed with specific activators to measure
      the coagulation time (CT), clot formation time (CFT) and the maximal clot
      firmness (MCF) in order to evaluate the extrinsic (EXTEM(R) test) and intrinsic
      (INTEM(R) test) coagulation systems, as well as the fibrinogen contribution to
      coagulation (FIBTEM(R) test). RESULTS: After exclusions, data from 54 subjects in
      each group were analysed. Parturients had significantly lower haemoglobin values 
      and platelet counts (P<0.01). Despite this, thromboelastometry exhibited
      significantly lower INTEM(R) CT (7.3%), INTEM(R) CFT (11.1%) and EXTEM(R) CFT
      (18.0%) in the pregnant group (P<0.001). MCF values were significantly higher
      (INTEM(R) (10.9%), EXTEM(R) (10.6%) and FIBTEM(R) (47.1%)) in the pregnant group 
      compared to the non-pregnant group (P<0.0001). CONCLUSIONS: ROTEM(R)
      thromboelastometry clearly demonstrates the hypercoagulability of pregnancy.
      Formal reference ranges for ROTEM(R) that may be potentially useful in the
      haemostatic management of the parturient are presented.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Armstrong, S
AU  - Armstrong S
AD  - Department of Anaesthesia, University College Hospital, London, UK.
      drsaraharmstrong@gmail.com
FAU - Fernando, R
AU  - Fernando R
FAU - Ashpole, K
AU  - Ashpole K
FAU - Simons, R
AU  - Simons R
FAU - Columb, M
AU  - Columb M
LA  - eng
GR  - Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110810
PL  - Netherlands
TA  - Int J Obstet Anesth
JT  - International journal of obstetric anesthesia
JID - 9200430
SB  - IM
MH  - Adult
MH  - *Blood Coagulation
MH  - Female
MH  - Humans
MH  - Pregnancy/*blood
MH  - Pregnancy Trimester, Third
MH  - Thrombelastography/*instrumentation
EDAT- 2011/08/13 06:00
MHDA- 2012/02/10 06:00
CRDT- 2011/08/13 06:00
PHST- 2010/11/29 00:00 [received]
PHST- 2011/05/10 00:00 [revised]
PHST- 2011/05/24 00:00 [accepted]
PHST- 2011/08/13 06:00 [entrez]
PHST- 2011/08/13 06:00 [pubmed]
PHST- 2012/02/10 06:00 [medline]
AID - S0959-289X(11)00050-1 [pii]
AID - 10.1016/j.ijoa.2011.05.004 [doi]
PST - ppublish
SO  - Int J Obstet Anesth. 2011 Oct;20(4):293-8. doi: 10.1016/j.ijoa.2011.05.004. Epub 
      2011 Aug 10.


PMID- 21835528
OWN - NLM
STAT- MEDLINE
DCOM- 20120117
LR  - 20161125
IS  - 1531-5053 (Electronic)
IS  - 0278-2391 (Linking)
VI  - 69
IP  - 12
DP  - 2011 Dec
TI  - Zygomatic implant placement with flapless computer-guided surgery: a proposed
      clinical protocol.
PG  - 2979-89
LID - 10.1016/j.joms.2011.03.050 [doi]
AB  - PURPOSE: The aim of the present report is to describe a procedure for zygomatic
      implant placement using image-guided implant surgery. This is an innovative
      technique and includes a new clinical approach to provide the direction to guide 
      drilling. MATERIALS AND METHODS: The ethical committee of the University of Genoa
      approved the study. All patients had clinical indications of severe maxillary
      atrophy (Class 4 Cadwood-Howell). A total of 25 implants were placed, of which 17
      were in the premaxilla, 7 in the zygomatic area, and 1 in the pterygoid bone. The
      treatment was performed in 2 phases. The first phase included cone-beam
      acquisition to exclude sinus disease and evaluate the anatomy of the residual
      premaxillary bone in 3 dimensions. The success of osseointegration achieved by
      the primary implants (PIs) was confirmed after temporary loading and before
      proceeding with the second phase, in which all patients were scheduled for
      zygomatic implants. A total of 3 or 4 regular platform MK III implants (17 in
      all) were placed in the premaxilla using conventional implant surgery. A model
      within the analogs of the PIs was prepared (master model), taking a conventional 
      impression. Next, a radiologic template was prepared on the same master model and
      stabilized on the PIs, using dedicated prosthetic components. The guide was
      screwed onto the PIs during computed tomography acquisition to determine a fixed 
      and repeatable position of the guide. In the second phase, after routine
      planning, a mucosa-supported stereolithographic SurgiGuide with sleeves for the
      zygomatic implants and the corresponding stereolithographic model, including the 
      mucosa, were received from the manufacturers. The guide was repositioned on the
      master model to replace the sleeves for the PIs in the same position. With an
      original customized surgical kit, including an innovative intrasinus device, we
      next simulated surgery on the stereolithographic model to determine and control
      the direction of the osteotomies and the final depth of drilling. The SurgiGuide 
      was anchored onto the PIs before the zygomatic osteotomy, after which flapless
      surgery was performed to place the zygomatic implants according to the plan.
      RESULTS: Two PIs in the premaxillary area failed (and were replaced before the
      zygomatic step). No zygomatic implants failed. The follow-up examinations at 4 to
      39 months showed good esthetic, phonetic, and functional results. CONCLUSIONS:
      The results of the proposed surgical procedure appear to be encouraging. Although
      it is difficult to achieve the correct driven angle of osteotomies for zygomatic 
      implants, in all patients we achieved correct zygomatic positioning, in agreement
      with previous planning. Additional research and randomized clinical trials are
      needed to assess the predictability of the procedure.
CI  - Copyright (c) 2011 American Association of Oral and Maxillofacial Surgeons.
      Published by Elsevier Inc. All rights reserved.
FAU - Schiroli, Guido
AU  - Schiroli G
AD  - University of Genoa, Department of Medical, Biophysical, Dental Science and
      Technologies, DISTIBIMO, Genoa, Italy. schirol@tin.it
FAU - Angiero, Francesca
AU  - Angiero F
FAU - Silvestrini-Biavati, Armando
AU  - Silvestrini-Biavati A
FAU - Benedicenti, Stefano
AU  - Benedicenti S
LA  - eng
PT  - Journal Article
DEP - 20110811
PL  - United States
TA  - J Oral Maxillofac Surg
JT  - Journal of oral and maxillofacial surgery : official journal of the American
      Association of Oral and Maxillofacial Surgeons
JID - 8206428
SB  - IM
MH  - Alveolar Bone Loss/diagnostic imaging/*rehabilitation
MH  - Clinical Protocols
MH  - Cone-Beam Computed Tomography
MH  - Dental Implantation, Endosseous/*methods
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Imaging, Three-Dimensional
MH  - Jaw, Edentulous/rehabilitation
MH  - Maxilla/diagnostic imaging
MH  - Maxillary Sinus/surgery
MH  - *Models, Anatomic
MH  - *Surgery, Computer-Assisted
MH  - Treatment Outcome
MH  - User-Computer Interface
MH  - Zygoma/*surgery
EDAT- 2011/08/13 06:00
MHDA- 2012/01/18 06:00
CRDT- 2011/08/13 06:00
PHST- 2010/10/09 00:00 [received]
PHST- 2011/02/25 00:00 [revised]
PHST- 2011/03/29 00:00 [accepted]
PHST- 2011/08/13 06:00 [entrez]
PHST- 2011/08/13 06:00 [pubmed]
PHST- 2012/01/18 06:00 [medline]
AID - S0278-2391(11)00589-1 [pii]
AID - 10.1016/j.joms.2011.03.050 [doi]
PST - ppublish
SO  - J Oral Maxillofac Surg. 2011 Dec;69(12):2979-89. doi: 10.1016/j.joms.2011.03.050.
      Epub 2011 Aug 11.


PMID- 21835471
OWN - NLM
STAT- MEDLINE
DCOM- 20120102
LR  - 20110830
IS  - 1532-6586 (Electronic)
IS  - 0161-4754 (Linking)
VI  - 34
IP  - 7
DP  - 2011 Sep
TI  - The perspectives and practices of alberta chiropractors regarding the sale of
      health care products in chiropractic offices.
PG  - 476-82
LID - 10.1016/j.jmpt.2011.05.013 [doi]
AB  - OBJECTIVE: The purpose of this study is to describe the practices and
      perspectives of doctors of chiropractic in Alberta, Canada, regarding the sale of
      health products. This practice is considered in terms of ethical principles and
      professional practice standards. METHODS: Chiropractic Web sites in Alberta were 
      identified using the publically available Web site of the Alberta College and
      Association of Chiropractors. A random sample of chiropractors was drawn and
      mailed a brief 4-page survey and return envelope. There was a follow-up mail out 
      to nonrespondents 3 weeks later. Practitioners provided responses regarding their
      personal and professional characteristics and their perspectives and practices
      regarding health product sales. RESULTS: A total of 265 responses were received
      (response rate, 51.2%). Most practitioners endorsed health product sales by
      chiropractors (95%), and most were engaged in the practice (89%). Orthotics (77%)
      and pillows (69%) were sold most often, followed by nutritional supplements
      (68%), hot/cold packs (68%), and vitamins (52%). Some respondents identified
      areas of potential ethical concern, including product safety and efficacy,
      professional influence on consumer product purchase, and potential conflict of
      interest. Codes of ethics and conduct offer some guidance to practitioners, but
      their awareness of standards varied. CONCLUSIONS: The chiropractic profession
      within Alberta condones product sales, and most of its membership engages in the 
      practice. Individual members differ in their perspectives on this practice and in
      their awareness of the national code of ethics and conduct.
CI  - Copyright (c) 2011 National University of Health Sciences. Published by Mosby,
      Inc. All rights reserved.
FAU - Page, Stacey A
AU  - Page SA
AD  - Senior Research Associate, Office of Medical Bioethics, and Adjunct Assistant
      Professor, Department of Community Health Sciences, Faculty of Medicine,
      University of Calgary, Calgary, Alberta, Canada. sapage@ucalgary.ca
FAU - Grod, Jaroslaw P
AU  - Grod JP
FAU - McMorland, D Gordon
AU  - McMorland DG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110810
PL  - United States
TA  - J Manipulative Physiol Ther
JT  - Journal of manipulative and physiological therapeutics
JID - 7807107
SB  - IM
MH  - Adult
MH  - Alberta
MH  - *Attitude
MH  - *Chiropractic/instrumentation
MH  - *Commerce
MH  - Data Collection
MH  - *Equipment and Supplies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Professional Practice
EDAT- 2011/08/13 06:00
MHDA- 2012/01/03 06:00
CRDT- 2011/08/13 06:00
PHST- 2011/01/27 00:00 [received]
PHST- 2011/04/08 00:00 [revised]
PHST- 2011/05/13 00:00 [accepted]
PHST- 2011/08/13 06:00 [entrez]
PHST- 2011/08/13 06:00 [pubmed]
PHST- 2012/01/03 06:00 [medline]
AID - S0161-4754(11)00121-7 [pii]
AID - 10.1016/j.jmpt.2011.05.013 [doi]
PST - ppublish
SO  - J Manipulative Physiol Ther. 2011 Sep;34(7):476-82. doi:
      10.1016/j.jmpt.2011.05.013. Epub 2011 Aug 10.


PMID- 21834969
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121204
LR  - 20220408
IS  - 1756-0500 (Electronic)
IS  - 1756-0500 (Linking)
VI  - 4
DP  - 2011 Aug 11
TI  - Serum ferritin levels, socio-demographic factors and desferrioxamine therapy in
      multi-transfused thalassemia major patients at a government tertiary care
      hospital of Karachi, Pakistan.
PG  - 287
LID - 10.1186/1756-0500-4-287 [doi]
AB  - BACKGROUND: Beta thalassemia is the most frequent genetic disorder of haemoglobin
      synthesis in Pakistan. Recurrent transfusions lead to iron-overload manifested by
      increased serum Ferritin levels, for which chelation therapy is required.
      FINDINGS: The study was conducted in the Pediatric Emergency unit of Civil
      Hospital Karachi after ethical approval by the Institutional Review Board of Dow 
      University of Health Sciences. Seventy nine cases of beta thalassemia major were 
      included after a written consent. The care takers were interviewed for the
      socio-demographic variables and the use of Desferrioxamine therapy, after which a
      blood sample was drawn to assess the serum Ferritin level. SPSS 15.0 was employed
      for data entry and analysis.Of the seventy-nine patients included in the study,
      46 (58.2%) were males while 33 (41.8%) were females. The mean age was 10.8 (+/-
      4.5) years with the dominant age group (46.2%) being 10 to 14 years. In 62
      (78.8%) cases, the care taker education was below the tenth grade. The mean serum
      Ferritin level in our study were 4236.5 ng/ml and showed a directly proportional 
      relationship with age. Desferrioxamine was used by patients in 46 (58.2%) cases
      with monthly house hold income significant factor to the use of therapy.
      CONCLUSIONS: The mean serum Ferritin levels are approximately ten times higher
      than the normal recommended levels for normal individuals, with two-fifths of the
      patients not receiving iron chelation therapy at all. Use of iron chelation
      therapy and titrating the dose according to the need can significantly lower the 
      iron load reducing the risk of iron-overload related complications leading to a
      better quality of life and improving survival in Pakistani beta thalassemia major
      patients.Conflicts of Interest: None.
FAU - Riaz, Haris
AU  - Riaz H
AD  - House officer, Civil Hospital Karachi, Pakistan. harisriaz73@yahoo.com.
FAU - Riaz, Talha
AU  - Riaz T
FAU - Khan, Muhammad Ubaid
AU  - Khan MU
FAU - Aziz, Sina
AU  - Aziz S
FAU - Ullah, Faizan
AU  - Ullah F
FAU - Rehman, Anis
AU  - Rehman A
FAU - Zafar, Qandeel
AU  - Zafar Q
FAU - Kazi, Abdul Nafey
AU  - Kazi AN
LA  - eng
PT  - Journal Article
DEP - 20110811
PL  - England
TA  - BMC Res Notes
JT  - BMC research notes
JID - 101462768
PMC - PMC3162919
EDAT- 2011/08/13 06:00
MHDA- 2011/08/13 06:01
CRDT- 2011/08/13 06:00
PHST- 2011/07/11 00:00 [received]
PHST- 2011/08/11 00:00 [accepted]
PHST- 2011/08/13 06:00 [entrez]
PHST- 2011/08/13 06:00 [pubmed]
PHST- 2011/08/13 06:01 [medline]
AID - 1756-0500-4-287 [pii]
AID - 10.1186/1756-0500-4-287 [doi]
PST - epublish
SO  - BMC Res Notes. 2011 Aug 11;4:287. doi: 10.1186/1756-0500-4-287.


PMID- 21834841
OWN - NLM
STAT- MEDLINE
DCOM- 20120131
LR  - 20110928
IS  - 1365-2753 (Electronic)
IS  - 1356-1294 (Linking)
VI  - 17
IP  - 5
DP  - 2011 Oct
TI  - Considering virtue: public health and clinical ethics.
PG  - 888-93
LID - 10.1111/j.1365-2753.2011.01721.x [doi]
AB  - As bioethicists increasingly turn their attention to the profession of public
      health, many candidate frameworks have been proposed, often with an eye toward
      articulating the values and foundational concepts that distinguish this practice 
      from curative clinical medicine. First, I will argue that while these suggestions
      for a distinct ethics of public health are promising, they arise from problems
      within contemporary bioethics that must be taken into account. Without such
      cognizance of the impetus for public health ethics, we risk developing a set of
      ethical resources meant exclusively for public health professionals, thereby
      neglecting implications for curative medical ethics and the practice of bioethics
      more broadly. Second, I will present reasons for thinking some of the critiques
      of dominant contemporary bioethics can be met by a virtue ethics approach. I
      present a virtue ethics response to criticisms that concern (1) increased rigor
      in bioethics discourse; (2) the ability of normative theory to accommodate
      context; and (3) explicit attention to the nature of ethical conflict. I conclude
      that a virtue ethics approach is a viable avenue for further inquiry, one that
      leads us away from developing ethics of public health in a vacuum and has the
      potential for overcoming certain pitfalls of contemporary bioethics discourse.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Meagher, Karen M
AU  - Meagher KM
AD  - Department of Philosophy, Michigan State University, East Lansing, Michigan
      48824-1316, USA. meagher6@msu.edu
LA  - eng
PT  - Journal Article
DEP - 20110811
PL  - England
TA  - J Eval Clin Pract
JT  - Journal of evaluation in clinical practice
JID - 9609066
SB  - IM
MH  - *Bioethics
MH  - Ethical Theory
MH  - Ethics, Clinical
MH  - Humans
MH  - Public Health/*ethics
MH  - *Virtues
EDAT- 2011/08/13 06:00
MHDA- 2012/02/01 06:00
CRDT- 2011/08/13 06:00
PHST- 2011/08/13 06:00 [entrez]
PHST- 2011/08/13 06:00 [pubmed]
PHST- 2012/02/01 06:00 [medline]
AID - 10.1111/j.1365-2753.2011.01721.x [doi]
PST - ppublish
SO  - J Eval Clin Pract. 2011 Oct;17(5):888-93. doi: 10.1111/j.1365-2753.2011.01721.x. 
      Epub 2011 Aug 11.


PMID- 21834832
OWN - NLM
STAT- MEDLINE
DCOM- 20120131
LR  - 20161125
IS  - 1365-2753 (Electronic)
IS  - 1356-1294 (Linking)
VI  - 17
IP  - 5
DP  - 2011 Oct
TI  - Health policy, patient-centred care and clinical ethics.
PG  - 913-9
LID - 10.1111/j.1365-2753.2011.01726.x [doi]
AB  - RATIONALE, AIMS AND OBJECTIVES: Patient-centred care has been a central part of
      US and UK health policy for over a decade, but, despite its importance, the
      policy literature often fails to provide an adequate theoretical justification
      for why and how we should value it. This omission is problematic because it
      renders the status, content and appropriate evaluation of patient-centredness
      unclear. In this paper we aim to examine two different accounts of
      patient-centred care. METHOD: We draw upon methods of conceptual and ethical
      analysis. RESULTS: We argue that neither of the two accounts of patient-centred
      care identified appropriately grounds patient-centredness because neither of them
      takes into account the inherently moral nature of terms such as 'respect' and
      'dignity', terms that are central to discussions of patient-centred care.
      CONCLUSIONS: We suggest that clinical ethics can help to provide a theoretical
      justification for patient-centred care, and that clinical ethical practices can
      further patient-centred initiatives through ethics consultation, education and
      policy development and review.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - McClimans, Leah M
AU  - McClimans LM
AD  - Warwick Medical School, The University of Warwick, Coventry, UK.
      mccliman@mailbox.sc.edu
FAU - Dunn, Michael
AU  - Dunn M
FAU - Slowther, Anne-Marie
AU  - Slowther AM
LA  - eng
PT  - Journal Article
DEP - 20110811
PL  - England
TA  - J Eval Clin Pract
JT  - Journal of evaluation in clinical practice
JID - 9609066
SB  - IM
MH  - *Ethics, Clinical
MH  - *Health Policy
MH  - Humans
MH  - Patient Participation
MH  - Patient-Centered Care/*ethics/*organization & administration
MH  - Philosophy, Medical
MH  - Quality of Health Care/ethics/organization & administration
MH  - United Kingdom
MH  - United States
EDAT- 2011/08/13 06:00
MHDA- 2012/02/01 06:00
CRDT- 2011/08/13 06:00
PHST- 2011/08/13 06:00 [entrez]
PHST- 2011/08/13 06:00 [pubmed]
PHST- 2012/02/01 06:00 [medline]
AID - 10.1111/j.1365-2753.2011.01726.x [doi]
PST - ppublish
SO  - J Eval Clin Pract. 2011 Oct;17(5):913-9. doi: 10.1111/j.1365-2753.2011.01726.x.
      Epub 2011 Aug 11.


PMID- 21834615
OWN - NLM
STAT- MEDLINE
DCOM- 20120821
LR  - 20181201
IS  - 1563-5279 (Electronic)
IS  - 0020-7454 (Linking)
VI  - 122
IP  - 1
DP  - 2012 Jan
TI  - Dopamine release is involved in antinociceptive effect of theophylline.
PG  - 17-21
LID - 10.3109/00207454.2011.613550 [doi]
AB  - The methylxanthines, e.g., theophylline, are widely used for the treatment of
      bronchial asthma. Additionally, a pain relieving effect of theophylline has been 
      reported in patients as well as in experimental animals. The mechanism of this
      antinociceptive action is not clear. In this study, involvement of dopaminergic
      system in theophylline-induced antinociception was evaluated using tail flick
      test model. Swiss albino mice, (either sex, weighing 25-30 g) with base line tail
      flick latencies (TFL) between 2.0 and 3.5 s, were used. TFL was recorded before
      and at intervals of 15, 30, 45, and 60 min. after drug treatment. The
      experimental protocol was duly approved by the Institutional Animal Ethics
      Committee, All India Institute of Medical Sciences, New Delhi, India. To
      determine the role of dopaminergic system, the mice were pretreated with either
      D1 or D2 dopaminergic receptor antagonists SCH 23390 and haloperidol,
      respectively, prior to treatment with theophylline. Another group of animals
      received apomorphine along with theophylline. The dose of theophylline used,
      i.e., 10 mg/kg, intraperitoneally (i.p.), had shown a significant increase in
      TFLs. The theophylline-induced antinociception, 10 mg/kg, i.p., was reversed by
      pretreatment with both D1 and D2 dopaminergic receptor antagonists SCH 23390 and 
      haloperidol as well as with apomorphine (1 mg/kg) pretreatment. The results
      suggest that theophylline-induced antinociception is due to release of dopamine.
FAU - Katyal, Jatinder
AU  - Katyal J
AD  - Neuropharmacology Laboratory, Department of Pharmacology, All India Institute of 
      Medical Sciences, New Delhi. jatinderkatyal.aiims@gmail.com
FAU - Gupta, Yogendra Kumar
AU  - Gupta YK
LA  - eng
PT  - Journal Article
DEP - 20110926
PL  - England
TA  - Int J Neurosci
JT  - The International journal of neuroscience
JID - 0270707
RN  - 0 (Analgesics)
RN  - 0 (Receptors, Dopamine)
RN  - C137DTR5RG (Theophylline)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Analgesics/*pharmacology
MH  - Animals
MH  - Disease Models, Animal
MH  - Dopamine/*metabolism
MH  - Female
MH  - Injections, Intraperitoneal
MH  - Male
MH  - Mice
MH  - Pain/*drug therapy/metabolism/physiopathology
MH  - Pain Measurement/methods
MH  - Pain Threshold/*drug effects/physiology
MH  - Receptors, Dopamine/drug effects/physiology
MH  - Theophylline/*pharmacology
MH  - Treatment Outcome
EDAT- 2011/08/13 06:00
MHDA- 2012/08/22 06:00
CRDT- 2011/08/13 06:00
PHST- 2011/08/13 06:00 [entrez]
PHST- 2011/08/13 06:00 [pubmed]
PHST- 2012/08/22 06:00 [medline]
AID - 10.3109/00207454.2011.613550 [doi]
PST - ppublish
SO  - Int J Neurosci. 2012 Jan;122(1):17-21. doi: 10.3109/00207454.2011.613550. Epub
      2011 Sep 26.


PMID- 21834376
OWN - NLM
STAT- MEDLINE
DCOM- 20110920
LR  - 20191112
IS  - 1536-5026 (Print)
IS  - 1536-5026 (Linking)
VI  - 32
IP  - 3
DP  - 2011 May-Jun
TI  - Defining pass/fail nursing student clinical behaviors phase I: moving toward a
      culture of safety.
PG  - 155-61
AB  - Achieving safe patient care underlies all of clinical nursing education. Nurse
      educators are professionally, legally, and ethically expected to anticipate
      safety risks for patients and prevent students from causing harm to patients in
      the clinical arena. When a student's behavior or behaviors pose a threat to
      patient safety, that student may be subject to a failing grade in the clinical
      nursing course. However, determining what student behaviors will result in
      failure in a clinical nursing course is challenging for even the most experienced
      nurse educators. Moving from a culture of blame to a culture of safety is also
      challenging. The authors developed a multiphase project to facilitate that move. 
      Phase I, the focus of this article, began with a qualitative study. Focus groups 
      of part-time and ranked faculty in baccalaureate nursing programs were conducted.
      The goal was to begin to identify faculty perspectives regarding nursing student 
      behaviors that result in failure in a clinical course. One major theme (context
      and patterns) and five subthemes (safety, thinking, ethics, communication, and
      standards) with clarifiers emerged from this study. Plans for the next four
      phases of the multiphased project are presented.
FAU - Tanicala, Martha L
AU  - Tanicala ML
AD  - School of Nursing, Eastern Michigan University, Ypsilanti, USA.
      mtanicala@emich.edu
FAU - Scheffer, Barbara K
AU  - Scheffer BK
FAU - Roberts, Melina S
AU  - Roberts MS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Nurs Educ Perspect
JT  - Nursing education perspectives
JID - 101140025
MH  - *Education, Nursing
MH  - Educational Measurement/*methods
MH  - Focus Groups
MH  - Humans
MH  - Nursing Education Research/methods
MH  - *Safety Management
MH  - United States
EDAT- 2011/08/13 06:00
MHDA- 2011/09/21 06:00
CRDT- 2011/08/13 06:00
PHST- 2011/08/13 06:00 [entrez]
PHST- 2011/08/13 06:00 [pubmed]
PHST- 2011/09/21 06:00 [medline]
AID - 10.5480/1536-5026-32.3.155 [doi]
PST - ppublish
SO  - Nurs Educ Perspect. 2011 May-Jun;32(3):155-61. doi: 10.5480/1536-5026-32.3.155.


PMID- 21834365
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20110812
IS  - 0040-4284 (Print)
IS  - 0040-4284 (Linking)
VI  - 128
IP  - 5
DP  - 2011 May
TI  - Living in limbo: ethics and experience in a conversation about persistent oral
      lesions.
PG  - 427-37
AB  - This case report presents a conversation that the authors had with a patient who 
      is suffering from oral lichen planus and oral cancer. The reason that the authors
      approached the patient for an interview was to find out why he decided to enroll 
      in an experimental study related to his oral cancer. The patient reported that it
      was "the waiting" that led him to enroll in this study--that is, the pressure of 
      waiting for oral cancer to re-emerge was simply unbearable, and enrolling in this
      experimental study enabled him to take a more proactive approach to his illness. 
      The authors view this "waiting" as a "limbo experience" and reflect on the
      implications of this limbo experience for dental ethics and research ethics.
FAU - Flaitz, Catherine M
AU  - Flaitz CM
AD  - Department of Diagnostic Sciences, The University of Texas Dental Branch at
      Houston, 6516 M.D. Anderson Blvd., Room 3.094H, Houston, TX 77030-3402, USA.
      catherine.m.flaitz@uth.tmc.edu
FAU - Carlin, Nathan
AU  - Carlin N
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Tex Dent J
JT  - Texas dental journal
JID - 2984821R
MH  - Attitude to Health
MH  - Bioethical Issues
MH  - Carcinoma, Squamous Cell/*pathology/psychology
MH  - Cell Transformation, Neoplastic/pathology
MH  - Choice Behavior
MH  - Dentist-Patient Relations/ethics
MH  - Disease Progression
MH  - *Ethics, Dental
MH  - Humans
MH  - Leukoplakia, Oral/pathology
MH  - Lichen Planus, Oral/*pathology/psychology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/pathology/psychology
MH  - Patient Education as Topic
MH  - Personal Autonomy
MH  - Precancerous Conditions/*pathology/psychology
MH  - Quality of Life
MH  - Randomized Controlled Trials as Topic
MH  - Stress, Psychological/psychology
MH  - Tongue Neoplasms/*pathology/psychology
MH  - Truth Disclosure/ethics
EDAT- 2011/08/13 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/08/13 06:00
PHST- 2011/08/13 06:00 [entrez]
PHST- 2011/08/13 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
PST - ppublish
SO  - Tex Dent J. 2011 May;128(5):427-37.


PMID- 21834361
OWN - NLM
STAT- MEDLINE
DCOM- 20110913
LR  - 20191112
IS  - 0745-5194 (Print)
IS  - 0745-5194 (Linking)
VI  - 25
IP  - 2
DP  - 2011 Jun
TI  - Debating life after disaster: charity hospital babies and bioscientific futures
      in post-Katrina New Orleans.
PG  - 254-77
AB  - In Louisiana's unique, populist-derived charity health system, the
      self-designation Charity Hospital Baby expresses situational identity anchored in
      the life cycle and the inversion of racist and authoritative connotations. This
      article draws on theoretical perspectives of stratified reproduction and the
      politics of time to examine the controversy in which Babies advocate reopening
      the Katrina-damaged New Orleans Charity Hospital, and administrators and planners
      support a new state-of-the-art biosciences district, GNOBED. Babies evoke the
      present, ethical urgency (kairos) of responding to sickness and disability;
      GNOBED implies prolonging or saving future lives through biotechnologies under
      development in accelerated time (chronos). As preservationists and residents
      threatened with displacement join "re-open Charity" proponents, planners
      symbolically engage in prolepsis, rhetorically precluding opposing arguments with
      flash forward of supposedly "done deals." At stake is nothing less than social
      death for a segment of this ethnically diverse city. [public
FAU - Lovell, Anne M
AU  - Lovell AM
AD  - Centre de Recherche Medecine, Sciences, Sante, Sante Mentale et Societee (CERMES 
      3--CESAMES), INSERM and Universite Paris-Rene Descartes.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Med Anthropol Q
JT  - Medical anthropology quarterly
JID - 8405037
SB  - IM
MH  - *Cyclonic Storms
MH  - *Disasters
MH  - Euthanasia
MH  - *Hospitals, Private
MH  - *Hospitals, Public
MH  - Humans
MH  - New Orleans
MH  - Relief Work/*ethics
MH  - Socioeconomic Factors
EDAT- 2011/08/13 06:00
MHDA- 2011/09/14 06:00
CRDT- 2011/08/13 06:00
PHST- 2011/08/13 06:00 [entrez]
PHST- 2011/08/13 06:00 [pubmed]
PHST- 2011/09/14 06:00 [medline]
AID - 10.1111/j.1548-1387.2011.01152.x [doi]
PST - ppublish
SO  - Med Anthropol Q. 2011 Jun;25(2):254-77. doi: 10.1111/j.1548-1387.2011.01152.x.


PMID- 21834359
OWN - NLM
STAT- MEDLINE
DCOM- 20110913
LR  - 20211020
IS  - 0745-5194 (Print)
IS  - 0745-5194 (Linking)
VI  - 25
IP  - 2
DP  - 2011 Jun
TI  - Medicare, ethics, and reflexive longevity: governing time and treatment in an
      aging society.
PG  - 209-31
AB  - The clinical activities that constitute longevity making in the United States are
      perhaps the quintessential example of a dynamic modern temporality, characterized
      by the quest for risk reduction, the powerful progress narratives of science and 
      medicine, and the personal responsibility of calculating the worth of more time
      in relation to medical options and age. This article explores how medicine
      materializes and problematizes time through a discussion of ethicality-in this
      case, the form of governance in which scientific evidence, Medicare policy and
      clinical knowledge and practice organize first, what becomes "thinkable" as the
      best medicine, and second, how that kind of understanding shapes a telos of
      living. Using liver disease and liver transplantation in the United States as my 
      example, I explore the influence of Medicare coverage decisions on treatments,
      clinical standards, and ethical necessity. Reflexive longevity-a relentless
      future-thinking about life itself-is one feature of this ethicality.
FAU - Kaufman, Sharon R
AU  - Kaufman SR
AD  - Department of Anthropology, History and Social Medicine, Institute for Health and
      Aging, University of California, San Francisco, USA.
FAU - Fjord, Lakshmi
AU  - Fjord L
LA  - eng
GR  - R01 AG028426/AG/NIA NIH HHS/United States
GR  - R01AG2846/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Med Anthropol Q
JT  - Medical anthropology quarterly
JID - 8405037
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Attitude of Health Personnel
MH  - Attitude to Health
MH  - *Bioethics
MH  - Female
MH  - Humans
MH  - Liver Transplantation/psychology
MH  - *Longevity
MH  - Male
MH  - Medicare/*ethics
MH  - United States
PMC - PMC3555685
MID - NIHMS432484
EDAT- 2011/08/13 06:00
MHDA- 2011/09/14 06:00
CRDT- 2011/08/13 06:00
PHST- 2011/08/13 06:00 [entrez]
PHST- 2011/08/13 06:00 [pubmed]
PHST- 2011/09/14 06:00 [medline]
AID - 10.1111/j.1548-1387.2011.01150.x [doi]
PST - ppublish
SO  - Med Anthropol Q. 2011 Jun;25(2):209-31. doi: 10.1111/j.1548-1387.2011.01150.x.


PMID- 21834266
OWN - NLM
STAT- MEDLINE
DCOM- 20110825
LR  - 20181201
IS  - 0309-3913 (Print)
IS  - 0309-3913 (Linking)
VI  - 40
IP  - 1
DP  - 2011 Mar
TI  - A pilot study assessing litigation in health care services in Nigeria.
PG  - 85-9
AB  - Litigation in healthcare system especially in nursing practice is rapidly
      increasing globally. Litigation affords an individual explanation and
      compensation for perceived wrong acts. It also serves to control all service
      providers. However, observation shows that health care providers in Nigeria
      behave as if they are litigation proof even in the presence of gross malpractice 
      and negligence. The prime concern of this study attempts finding out Nigerians
      attitudes to litigation. This paper reports the result of the qualitative aspect 
      of the study. In-depth interviews were conducted from January, 2006- March, 2007 
      for purposive and randomly selected fifty (50) adults from different ethnic,
      cultural, and social backgrounds. The study was carried out in Ibadan, the
      largest city of Nigeria. The instrument was a semi structured interview guide
      designed to assess the use of orthodox medical practice by Nigerians; examine
      Nigerians experience of unethical practice or injustice; identify Nigerians'
      attitude to litigation in health care practices and identify factors responsible 
      for their attitudes to litigation. Data were analysed using content analysis. The
      result shows that Nigerians utilize the hospitals and are aware of their rights
      as consumers of healthcare services but show poor attitudes to litigation for
      different reasons. This attitude was found to be a function of the prevailing
      socio-cultural factors in Nigeria. Litigation is at low ebb in Nigeria, health
      care providers should endeavour to deliver safe and ethically sound care despite 
      the prevailing circumstances. Health care is a fundamental human right and so,
      should be provided with dignity and people should have access to dignified
      treatment always.
FAU - Oyetunde, M O
AU  - Oyetunde MO
AD  - Department of Nursing, College of Medicine, University of Ibadan, Ibadan,
      Nigeria. dusoyet@yahoo.com
LA  - eng
PT  - Journal Article
PL  - Nigeria
TA  - Afr J Med Med Sci
JT  - African journal of medicine and medical sciences
JID - 7801013
SB  - IM
MH  - Adult
MH  - Aged
MH  - Attitude to Health/ethnology
MH  - Culture
MH  - Female
MH  - Health Services/*legislation & jurisprudence/*statistics & numerical data
MH  - Hospitals
MH  - Humans
MH  - Interviews as Topic
MH  - *Jurisprudence
MH  - Male
MH  - Medical Errors
MH  - Middle Aged
MH  - Nigeria
MH  - *Patient Rights
MH  - Pilot Projects
MH  - Qualitative Research
MH  - Religion
MH  - Socioeconomic Factors
MH  - Surveys and Questionnaires
EDAT- 2011/08/13 06:00
MHDA- 2011/08/27 06:00
CRDT- 2011/08/13 06:00
PHST- 2011/08/13 06:00 [entrez]
PHST- 2011/08/13 06:00 [pubmed]
PHST- 2011/08/27 06:00 [medline]
PST - ppublish
SO  - Afr J Med Med Sci. 2011 Mar;40(1):85-9.


PMID- 21833784
OWN - NLM
STAT- MEDLINE
DCOM- 20131126
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 1
DP  - 2013 Mar
TI  - Getting started: helping a new profession develop an ethics program.
PG  - 259-64
LID - 10.1007/s11948-011-9279-x [doi]
AB  - Both of us have been involved with helping professions, especially new scientific
      or technological professions, develop ethics programs-for undergraduates,
      graduates, and practitioners. By "ethics program", we mean any strategy for
      teaching ethics, including developing materials. Our purpose here is to
      generalize from that experience to identify the chief elements needed to get an
      ethics program started in a new profession. We are focusing on new professions
      for two reasons. First, all the older professions, both in the US and in most
      other countries, now have ethics programs of some sort. They do not need our
      advice to get started. Second, new professions face special problems just because
      they are new-everything from deciding who belongs to the profession to
      formalizing ethical standards so that they can be taught. Our purpose in this
      paper is to generalize from our experience and to identify some of the
      fundamentals for getting an ethics program started in a new profession. We
      present our recommendations in the form of response to 6 questions anyone
      designing an ethics program for a new profession should ask. We realize that our 
      brief discussion does not provide a complete treatment of the subject. Our
      purpose has been to point in the right direction those considering an ethics
      program for new profession.
FAU - Davis, Michael
AU  - Davis M
AD  - Humanities Department, Illinois Institute of Technology, Chicago, IL 60616, USA. 
      davism@iit.edu
FAU - Keefer, Matthew W
AU  - Keefer MW
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20110811
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Ethics, Professional/*education
MH  - Guidelines as Topic
MH  - Humans
MH  - *Program Development
MH  - *Social Responsibility
MH  - United States
EDAT- 2011/08/13 06:00
MHDA- 2013/12/16 06:00
CRDT- 2011/08/12 06:00
PHST- 2011/03/17 00:00 [received]
PHST- 2011/04/20 00:00 [accepted]
PHST- 2011/08/12 06:00 [entrez]
PHST- 2011/08/13 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1007/s11948-011-9279-x [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Mar;19(1):259-64. doi: 10.1007/s11948-011-9279-x. Epub 2011 
      Aug 11.


PMID- 21831490
OWN - NLM
STAT- MEDLINE
DCOM- 20120315
LR  - 20111118
IS  - 1532-3099 (Electronic)
IS  - 0266-6138 (Linking)
VI  - 27
IP  - 6
DP  - 2011 Dec
TI  - Is not testing a major change in clinical practice an ethical dilemma?
PG  - e301-2
LID - 10.1016/j.midw.2010.03.003 [doi]
FAU - Della, Forster A
AU  - Della FA
AD  - Mother and Child Health Research, La Trobe University, 324-328 Little Lonsdale
      Street, Melbourne 3000, Australia.
FAU - Anita, Moorhead
AU  - Anita M
FAU - Susan, Jacobs
AU  - Susan J
FAU - Lisa, Amir H
AU  - Lisa AH
FAU - Susan, Walker
AU  - Susan W
FAU - Kerri, McEgan
AU  - Kerri M
FAU - Gillian, Opie
AU  - Gillian O
FAU - Catharine, McNamara
AU  - Catharine M
FAU - Rachael, Ford
AU  - Rachael F
LA  - eng
PT  - Journal Article
DEP - 20110809
PL  - Scotland
TA  - Midwifery
JT  - Midwifery
JID - 8510930
MH  - *Colostrum
MH  - Diabetes, Gestational/*metabolism/nursing
MH  - *Ethics, Nursing
MH  - Female
MH  - Gestational Age
MH  - Humans
MH  - Infant Nutritional Physiological Phenomena
MH  - Infant, Newborn
MH  - Infant, Newborn, Diseases/*prevention & control
MH  - Maternal-Fetal Exchange
MH  - Midwifery/*ethics/methods
MH  - Postpartum Period
MH  - Pregnancy
MH  - Pregnancy Outcome
MH  - Premature Birth/prevention & control
MH  - Prenatal Diagnosis/*ethics
EDAT- 2011/08/13 06:00
MHDA- 2012/03/16 06:00
CRDT- 2011/08/12 06:00
PHST- 2010/03/16 00:00 [received]
PHST- 2010/03/22 00:00 [accepted]
PHST- 2011/08/12 06:00 [entrez]
PHST- 2011/08/13 06:00 [pubmed]
PHST- 2012/03/16 06:00 [medline]
AID - S0266-6138(10)00038-0 [pii]
AID - 10.1016/j.midw.2010.03.003 [doi]
PST - ppublish
SO  - Midwifery. 2011 Dec;27(6):e301-2. doi: 10.1016/j.midw.2010.03.003. Epub 2011 Aug 
      9.


PMID- 21831353
OWN - NLM
STAT- MEDLINE
DCOM- 20111230
LR  - 20130226
IS  - 1097-6868 (Electronic)
IS  - 0002-9378 (Linking)
VI  - 205
IP  - 4
DP  - 2011 Oct
TI  - The professional responsibility model of obstetrical ethics: avoiding the perils 
      of clashing rights.
PG  - 315.e1-5
LID - 10.1016/j.ajog.2011.06.006 [doi]
AB  - Obstetric ethics is sometimes represented by polarized views. One extreme asserts
      the rights of the fetus as the overwhelming ethical consideration. Another
      extreme asserts the pregnant woman as the overwhelming ethical consideration.
      Both assertions are overly simplistic. Such oversimplification is called
      reductionism. This article explains the fallacy of rights-based reductionism and 
      2 models of obstetric ethics based on it and explains why the fetal rights
      reductionism model and the pregnant woman's rights reductionism model result in
      conceptual and clinical failure and therefore should be abandoned. The article
      argues for the professional responsibility model of obstetric ethics, which
      emphasizes the importance of medical science and compassionate clinical care of
      both the pregnant and fetal patient. The result is that responsible medical care 
      overrides the extremes of clashing rights.
CI  - Copyright (c) 2011 Mosby, Inc. All rights reserved.
FAU - Chervenak, Frank A
AU  - Chervenak FA
AD  - Department of Obstetrics and Gynecology, Weill Medical College of Cornell
      University, New York, NY, USA.
FAU - McCullough, Laurence B
AU  - McCullough LB
FAU - Brent, Robert L
AU  - Brent RL
LA  - eng
PT  - Journal Article
DEP - 20110612
PL  - United States
TA  - Am J Obstet Gynecol
JT  - American journal of obstetrics and gynecology
JID - 0370476
SB  - IM
MH  - *Human Rights
MH  - *Liability, Legal
MH  - Models, Theoretical
MH  - Obstetrics/*ethics
EDAT- 2011/08/13 06:00
MHDA- 2011/12/31 06:00
CRDT- 2011/08/12 06:00
PHST- 2011/04/13 00:00 [received]
PHST- 2011/06/02 00:00 [accepted]
PHST- 2011/08/12 06:00 [entrez]
PHST- 2011/08/13 06:00 [pubmed]
PHST- 2011/12/31 06:00 [medline]
AID - S0002-9378(11)00734-4 [pii]
AID - 10.1016/j.ajog.2011.06.006 [doi]
PST - ppublish
SO  - Am J Obstet Gynecol. 2011 Oct;205(4):315.e1-5. doi: 10.1016/j.ajog.2011.06.006.
      Epub 2011 Jun 12.


PMID- 21828304
OWN - NLM
STAT- MEDLINE
DCOM- 20111003
LR  - 20110810
IS  - 1930-7837 (Electronic)
IS  - 0022-0337 (Linking)
VI  - 75
IP  - 8
DP  - 2011 Aug
TI  - Foreign-trained dentists' perceived knowledge and skills after graduation from a 
      structured two-year program.
PG  - 1098-106
AB  - In this survey study, graduates of the University of Western Ontario program for 
      foreign-trained dentists from 1999 to 2009 were asked for their perceptions of
      their knowledge and skill in fourteen clinical topic areas before they were
      admitted to the program and after graduation. Their ratings were made on a
      ten-point visual analog scale divided into three aptitude domains: competent,
      proficient, and master/expert. Definitions of each domain were provided. The
      majority of the respondents felt that their knowledge level improved at least one
      aptitude level in only four of the fourteen (29 percent) topic areas but that
      their skill level had increased at least one aptitude level in nine (64 percent) 
      topic areas. Of note, clinical topics with content reflective of North American
      dental practice such as oral medicine and treatment planning, ethics, regulated
      dentistry, record keeping, and informed consent were the topic areas in which
      most respondents reported an improvement in both their knowledge and skill. It is
      suggested that programs evaluating or providing gap training for internationally 
      trained dentists consider mandatory inclusion of these topics.
FAU - Kogon, Stanley
AU  - Kogon S
AD  - School of Dentistry, Schulich School of Medicine and Dentistry, University of
      Western Ontario, London, Ontario N6A 5C1, Canada. stan.kogon@schulich.uwo.ca
FAU - Banting, David W
AU  - Banting DW
FAU - Sandhu, Harinder
AU  - Sandhu H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Dent Educ
JT  - Journal of dental education
JID - 8000150
SB  - IM
MH  - Adult
MH  - Asia/ethnology
MH  - Attitude of Health Personnel
MH  - Certification
MH  - Clinical Competence
MH  - Curriculum
MH  - Data Collection
MH  - *Education, Dental
MH  - *Education, Professional, Retraining
MH  - Female
MH  - Foreign Professional Personnel/*education/*psychology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Ontario
MH  - Self Efficacy
MH  - *Self-Assessment
MH  - Young Adult
EDAT- 2011/08/11 06:00
MHDA- 2011/10/04 06:00
CRDT- 2011/08/11 06:00
PHST- 2011/08/11 06:00 [entrez]
PHST- 2011/08/11 06:00 [pubmed]
PHST- 2011/10/04 06:00 [medline]
AID - 75/8/1098 [pii]
PST - ppublish
SO  - J Dent Educ. 2011 Aug;75(8):1098-106.


PMID- 21828190
OWN - NLM
STAT- MEDLINE
DCOM- 20111109
LR  - 20220309
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 261
IP  - 1
DP  - 2011 Oct
TI  - MR imaging and outcome of term neonates with perinatal asphyxia: value of
      diffusion-weighted MR imaging and (1)H MR spectroscopy.
PG  - 235-42
LID - 10.1148/radiol.11110213 [doi]
AB  - PURPOSE: To compare the association between neurodevelopmental outcome in
      neonates with hypoxic-ischemic encephalopathy following perinatal asphyxia and
      (a) apparent diffusion coefficients (ADCs) in the thalamus and basal ganglia at
      diffusion-weighted (DW) magnetic resonance (MR) imaging and (b) hydrogen 1 ((1)H)
      MR spectroscopic measurements in the basal ganglia. MATERIALS AND METHODS: This
      retrospective study was approved by the local ethics committee, and the
      requirement to obtain informed consent was waived. Eighty-one term neonates with 
      perinatal asphyxia underwent conventional and DW cranial MR imaging (median age, 
      4 days; age range, 1-14 days); 51 neonates also underwent (1)H MR spectroscopy.
      Neurodevelopment was assessed from 18 to 46 months. Patients with favorable and
      adverse outcomes were compared. Receiver operating characteristics analysis was
      performed in all patients, and uni- and multivariate logistic regression analyses
      were performed in 44 patients examined within 7 days of birth by using MR imaging
      scores, ADCs in the basal ganglia and thalamus, and (1)H MR spectroscopic
      measurements in the basal ganglia. RESULTS: An adverse outcome was seen in 28 of 
      all 81 neonates (20 died, seven developed cerebral palsy, and one had severe
      mental retardation) and 22 of the 44 neonates examined within 7 days of birth
      with both ADC and (1)H MR spectroscopy. Poor outcome was associated with (a)
      lower ADCs in the basal ganglia (P < .001) and thalamus (P = .001) of neonates
      examined within 7 days of birth and (b) a higher lactate (Lac)-N-acetylaspartate 
      (NAA) ratio in the basal ganglia (P < .001). Multivariate analysis showed that MR
      imaging score combined with Lac/NAA ratios or ADCs in the basal ganglia within
      the 1st week of life had a better association with outcome than did MR imaging
      alone (P = .006, area under the receiver operating characteristic curve [AUC] =
      0.85 with Lac/NAA ratio; P < .0001, AUC = 0.93 with ADCs in basal ganglia).
      CONCLUSION: The combination of MR imaging score with ADCs or Lac/NAA ratios in
      the basal ganglia has a better association with outcome of asphyxiated term
      neonates than does MR imaging alone.
CI  - (c) RSNA, 2011.
FAU - Alderliesten, Thomas
AU  - Alderliesten T
AD  - Department of Neonatology, Wilhelmina Children's Hospital, University Medical
      Center Utrecht, Utrecht, The Netherlands.
FAU - de Vries, Linda S
AU  - de Vries LS
FAU - Benders, Manon J N L
AU  - Benders MJ
FAU - Koopman, Corine
AU  - Koopman C
FAU - Groenendaal, Floris
AU  - Groenendaal F
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110809
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 7YNJ3PO35Z (Hydrogen)
SB  - IM
MH  - Asphyxia Neonatorum/*complications
MH  - Brain/*growth & development
MH  - *Diffusion Magnetic Resonance Imaging
MH  - Female
MH  - Humans
MH  - Hydrogen
MH  - Hypoxia-Ischemia, Brain/*diagnosis/*etiology
MH  - Infant, Newborn
MH  - *Magnetic Resonance Spectroscopy
MH  - Male
MH  - Retrospective Studies
EDAT- 2011/08/11 06:00
MHDA- 2011/11/10 06:00
CRDT- 2011/08/11 06:00
PHST- 2011/08/11 06:00 [entrez]
PHST- 2011/08/11 06:00 [pubmed]
PHST- 2011/11/10 06:00 [medline]
AID - radiol.11110213 [pii]
AID - 10.1148/radiol.11110213 [doi]
PST - ppublish
SO  - Radiology. 2011 Oct;261(1):235-42. doi: 10.1148/radiol.11110213. Epub 2011 Aug 9.


PMID- 21828188
OWN - NLM
STAT- MEDLINE
DCOM- 20111109
LR  - 20211020
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 261
IP  - 1
DP  - 2011 Oct
TI  - Timing of cardiovascular MR imaging after acute myocardial infarction: effect on 
      estimates of infarct characteristics and prediction of late ventricular
      remodeling.
PG  - 116-26
LID - 10.1148/radiol.11110228 [doi]
AB  - PURPOSE: To define the evolution of infarct characteristics with cardiovascular
      magnetic resonance (MR) imaging and to assess which of the cardiovascular MR data
      acquired at day 2 or at 1 week after acute myocardial infarction (AMI), is the
      stronger predictor of infarct size and left ventricular (LV) function measured at
      3 months. MATERIALS AND METHODS: The study protocol was reviewed and approved by 
      the local research ethics committee, and written informed consent was obtained.
      Forty-eight patients with reperfused AMI underwent cine, T2-weighted, and late
      gadolinium enhancement cardiovascular MR imaging at days 2, 7, 30, and 90 after
      index presentation. Continuous data between times were compared by using paired t
      tests or one-way analysis of variance. Multiple linear regression analyses were
      used to predict linear end points. RESULTS: Infarct size and extent of myocardial
      edema decreased significantly between day 2 and 1 week: Mean scar as a percentage
      of LV mass and standard deviation (SD), respectively, were 27.2 and 13.9 versus
      21.6 and 14.1 (P < .001), and myocardial edema as a percentage of LV mass and SD,
      respectively, were 37.9 and 15.2 versus 32.3 and 14.3 (P = .003). These changes
      were accompanied by a significant improvement in LV ejection fraction (LVEF):
      Mean percentage of LVEF and SD, respectively, were 41.7 and 9.6 versus 44.6 and
      10.1 (P < .001). When comparing data acquired at day 2 and 1 week, only
      cardiovascular MR data acquired at 1 week were independent predictors of LVEF and
      infarct size at 3 months. CONCLUSION: LVEF, infarct size, and extent of
      myocardial edema changed significantly during the 1st week after AMI. Overall,
      cardiovascular MR measurements acquired after 1 week have greater predictive
      value for infarct size and LV function at 3 months than data acquired at day 2.
CI  - (c) RSNA, 2011.
FAU - Mather, Adam N
AU  - Mather AN
AD  - Multidisciplinary Cardiovascular Research Centre, Division of Cardiovascular and 
      Neuronal Remodelling, Leeds Institute of Genetics, Health and Therapeutics,
      University of Leeds, Jubilee Wing, Leeds General Infirmary, Leeds LS1 3EX,
      England.
FAU - Fairbairn, Timothy A
AU  - Fairbairn TA
FAU - Artis, Nigel J
AU  - Artis NJ
FAU - Greenwood, John P
AU  - Greenwood JP
FAU - Plein, Sven
AU  - Plein S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110809
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Female
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*diagnosis
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Time Factors
MH  - *Ventricular Remodeling
PMC - PMC3184232
EDAT- 2011/08/11 06:00
MHDA- 2011/11/10 06:00
CRDT- 2011/08/11 06:00
PHST- 2011/08/11 06:00 [entrez]
PHST- 2011/08/11 06:00 [pubmed]
PHST- 2011/11/10 06:00 [medline]
AID - radiol.11110228 [pii]
AID - 10.1148/radiol.11110228 [doi]
PST - ppublish
SO  - Radiology. 2011 Oct;261(1):116-26. doi: 10.1148/radiol.11110228. Epub 2011 Aug 9.


PMID- 21828186
OWN - NLM
STAT- MEDLINE
DCOM- 20111109
LR  - 20220408
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 261
IP  - 1
DP  - 2011 Oct
TI  - Metastatic ovarian and primary peritoneal cancer: assessing chemotherapy response
      with diffusion-weighted MR imaging--value of histogram analysis of apparent
      diffusion coefficients.
PG  - 182-92
LID - 10.1148/radiol.11110577 [doi]
AB  - PURPOSE: To prospectively evaluate apparent diffusion coefficient (ADC)
      histograms in the prediction of chemotherapy response in patients with metastatic
      ovarian or primary peritoneal cancer. MATERIALS AND METHODS: Research ethics
      committee approval and patient written informed consent were obtained.
      Diffusion-weighted (DW) magnetic resonance (MR) imaging was performed through the
      abdomen and pelvis before and after one and three cycles of chemotherapy in 42
      women (mean age, 63.0 years +/- 11.4 [standard deviation]) with newly diagnosed
      or recurrent disease. Reproducibility and intra- and interobserver agreement of
      ADC calculations were assessed. Per-patient weighted ADC histograms were
      generated at each time point from pixel ADCs from five or fewer target lesions.
      Mean ADC, percentiles (10th, 25th, 50th, 75th, 90th), skew, kurtosis, and their
      change were analyzed according to histologic grade, primary versus recurrent
      disease status, and response, determined with integrated biochemical and
      morphologic criteria, with a linear mixed model. Areas under receiver operating
      characteristic curve (AUCs) for combinations of parameters were calculated with
      linear discriminant analysis. RESULTS: Coefficients of variation for repeat
      measurements and for within and between observers were 4.8%, 11.4%, and 13.7%,
      respectively. Grade and disease status did not significantly affect histogram
      parameters. Pretreatment ADCs were not predictive of response. In responders, all
      ADCs increased after the first and third cycle (P < .001), while skew and
      kurtosis decreased after the third (P < .001 and P = .006, respectively);
      however, in nonresponders, no parameter changed significantly. Percentage change 
      of the 25th percentile performed best in identifying response (AUC = 0.82 and
      0.83 after first and third cycle, respectively), whereas combination of
      parameters did not improve accuracy. CONCLUSION: An early increase of ADCs and
      later decrease of skew and kurtosis characterize chemotherapy response.
      Quantitative DW MR imaging can aid in early monitoring of treatment efficacy in
      patients with advanced ovarian cancer.
CI  - (c) RSNA, 2011.
FAU - Kyriazi, Stavroula
AU  - Kyriazi S
AD  - Cancer Research-UK and EPSRC Cancer Imaging Centre, Research Data Management and 
      Statistics Unit, and Department of Gynaecological Oncology, Royal Marsden NHS
      Foundation Trust and Institute of Cancer Research, Sutton, Surrey SM2 5PT,
      England. Stavroula.Kyriazi@icr.ac.uk
FAU - Collins, David J
AU  - Collins DJ
FAU - Messiou, Christina
AU  - Messiou C
FAU - Pennert, Kjell
AU  - Pennert K
FAU - Davidson, Robert L
AU  - Davidson RL
FAU - Giles, Sharon L
AU  - Giles SL
FAU - Kaye, Stan B
AU  - Kaye SB
FAU - Desouza, Nandita M
AU  - Desouza NM
LA  - eng
GR  - G0701533/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
DEP - 20110809
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Diffusion Magnetic Resonance Imaging
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Neoplasm Metastasis
MH  - Ovarian Neoplasms/*drug therapy/*pathology
MH  - Peritoneal Neoplasms/*drug therapy/*pathology
MH  - Prospective Studies
MH  - Treatment Outcome
EDAT- 2011/08/11 06:00
MHDA- 2011/11/10 06:00
CRDT- 2011/08/11 06:00
PHST- 2011/08/11 06:00 [entrez]
PHST- 2011/08/11 06:00 [pubmed]
PHST- 2011/11/10 06:00 [medline]
AID - radiol.11110577 [pii]
AID - 10.1148/radiol.11110577 [doi]
PST - ppublish
SO  - Radiology. 2011 Oct;261(1):182-92. doi: 10.1148/radiol.11110577. Epub 2011 Aug 9.


PMID- 21828079
OWN - NLM
STAT- MEDLINE
DCOM- 20120123
LR  - 20111004
IS  - 1758-1117 (Electronic)
IS  - 0023-6772 (Linking)
VI  - 45
IP  - 4
DP  - 2011 Oct
TI  - Rodent laparoscopy: refinement for rodent drug studies and model development, and
      monitoring of neoplastic, inflammatory and metabolic diseases.
PG  - 231-9
LID - 10.1258/la.2011.010027 [doi]
AB  - The refinement of surgical techniques represents a key opportunity to improve the
      welfare of laboratory rodents, while meeting legal and ethical obligations.
      Current methods used for monitoring intra-abdominal disease progression in
      rodents usually involve euthanasia at various time-points for end of study,
      one-time individual tissue collections. Most rodent organ tumour models are
      developed by the introduction of tumour cells via laparotomy or via
      ultrasound-guided indirect visualization. Ischaemic rodent models are often
      generated using laparotomies. This approach requires a high number of rodents,
      and in some instances introduces high degrees of morbidity and mortality, thereby
      increasing study variability and expense. Most importantly, most laparotomies do 
      not promote the highest level of rodent welfare. Recent improvements in
      laparoscopic equipment and techniques have enabled the adaptation of laparoscopy 
      for rodent procedures. Laparoscopy, which is considered the gold standard for
      many human abdominal procedures, allows for serial biopsy collections from the
      same animal, results in decreased pain and tissue trauma as well as quicker
      postsurgical recovery, and preserves immune function in comparison to the same
      procedures performed by laparotomy. Laparoscopy improves rodent welfare,
      decreases inter-animal variability, thereby reducing the number of required
      animals, allows for the replacement of larger species, decreases expense and
      improves data yield. This review article compares rodent laparotomy and
      laparoscopic surgical methods, and describes the utilization of laparoscopy for
      the development of cancer models and assessment of disease progression to improve
      data collection and animal welfare. In addition, currently available rodent
      laparoscopic equipment and instrumentation are presented.
FAU - Baran, Szczepan W
AU  - Baran SW
AD  - Veterinary Bioscience Institute, 292 Main Street, #300, Harleysville, PA 19438,
      USA. szczepanb@vetbiotech.com
FAU - Perret-Gentil, Marcel I
AU  - Perret-Gentil MI
FAU - Johnson, Elizabeth J
AU  - Johnson EJ
FAU - Miedel, Emily L
AU  - Miedel EL
FAU - Kehler, James
AU  - Kehler J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
DEP - 20110809
PL  - England
TA  - Lab Anim
JT  - Laboratory animals
JID - 0112725
SB  - IM
MH  - *Animal Welfare
MH  - Animals
MH  - *Animals, Laboratory
MH  - Laparoscopy/*instrumentation/*methods
MH  - Laparotomy/*methods
MH  - Monitoring, Physiologic/*methods
MH  - *Rodentia
EDAT- 2011/08/11 06:00
MHDA- 2012/01/24 06:00
CRDT- 2011/08/11 06:00
PHST- 2011/08/11 06:00 [entrez]
PHST- 2011/08/11 06:00 [pubmed]
PHST- 2012/01/24 06:00 [medline]
AID - la.2011.010027 [pii]
AID - 10.1258/la.2011.010027 [doi]
PST - ppublish
SO  - Lab Anim. 2011 Oct;45(4):231-9. doi: 10.1258/la.2011.010027. Epub 2011 Aug 9.


PMID- 21827381
OWN - NLM
STAT- MEDLINE
DCOM- 20120601
LR  - 20191112
IS  - 2212-3431 (Electronic)
IS  - 1872-2156 (Linking)
VI  - 5
IP  - 3
DP  - 2011 Dec
TI  - Biobanks between common good and private interest: the example of umbilical cord 
      blood private biobanks.
PG  - 166-8
AB  - Storage of human biological samples and personal data associated with them is
      organised in Biobanks. In spite of expectation given by biobanks in medicine,
      their management involved some ethical questions, for example, the need for
      policies to regulate economic interests, potential commercial use of data
      (including patents), private sector financing, ownership of samples and benefit
      sharing. In the context of contributing to the general public interest, we can
      consider the act of giving biological material to biobanks as a donation, in
      which the donation constitutes part of a generalised form of reciprocity in which
      the act of donation contributes to society's common good. Starting from this
      perspective, we move into a different situation represented by the biobanking of 
      umbilical cord blood for personal use. We used the example of the private
      biobanking of umbilical cords to demonstrate the restrictive utility of the
      collection and preservation of cord blood for personal use in private biobanks,
      in the context of society's common good. In summary, a system based on solidarity
      seems to be able to guarantee necessary levels of supply for the donation of
      biological material to biobanks.
FAU - Onisto, Maurizio
AU  - Onisto M
AD  - Department of Experimental Biomedical Sciences, University of Padova, Viale G.
      Colombo 3, 35121Padova, Italy. maurizio.onisto@unipd.it
FAU - Ananian, Viviana
AU  - Ananian V
FAU - Caenazzo, Luciana
AU  - Caenazzo L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United Arab Emirates
TA  - Recent Pat DNA Gene Seq
JT  - Recent patents on DNA & gene sequences
JID - 101299745
SB  - IM
MH  - Blood Banks/*ethics/*legislation & jurisprudence
MH  - European Union
MH  - *Fetal Blood
MH  - Humans
MH  - Patents as Topic
MH  - *Private Sector
MH  - Social Justice
EDAT- 2011/08/11 06:00
MHDA- 2012/06/02 06:00
CRDT- 2011/08/11 06:00
PHST- 2011/05/31 00:00 [received]
PHST- 2011/07/11 00:00 [revised]
PHST- 2011/07/13 00:00 [accepted]
PHST- 2011/08/11 06:00 [entrez]
PHST- 2011/08/11 06:00 [pubmed]
PHST- 2012/06/02 06:00 [medline]
AID - BSP/DNAG/E-PUB 00032 [pii]
AID - 10.2174/187221511797636301 [doi]
PST - ppublish
SO  - Recent Pat DNA Gene Seq. 2011 Dec;5(3):166-8. doi: 10.2174/187221511797636301.


PMID- 21826845
OWN - NLM
STAT- MEDLINE
DCOM- 20110906
LR  - 20110810
IS  - 0883-5381 (Print)
IS  - 0883-5381 (Linking)
VI  - 26
IP  - 4
DP  - 2011 Jul-Aug
TI  - Examining the code. ACHE's Code of Ethics highlights challenges faced by
      healthcare leaders.
PG  - 39-42, 44
FAU - Bowen, Deborah J
AU  - Bowen DJ
AD  - ACHE, USA.
FAU - Weil, Peter A
AU  - Weil PA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Healthc Exec
JT  - Healthcare executive
JID - 8612808
MH  - *Codes of Ethics
MH  - *Health Facility Administrators
MH  - Humans
MH  - *Societies
MH  - United States
EDAT- 2011/08/11 06:00
MHDA- 2011/09/07 06:00
CRDT- 2011/08/11 06:00
PHST- 2011/08/11 06:00 [entrez]
PHST- 2011/08/11 06:00 [pubmed]
PHST- 2011/09/07 06:00 [medline]
PST - ppublish
SO  - Healthc Exec. 2011 Jul-Aug;26(4):39-42, 44.


PMID- 21826716
OWN - NLM
STAT- MEDLINE
DCOM- 20120210
LR  - 20111020
IS  - 1520-6777 (Electronic)
IS  - 0733-2467 (Linking)
VI  - 30
IP  - 8
DP  - 2011 Nov
TI  - Prevalence of self-reported double incontinence in the urban population of a
      Brazilian city.
PG  - 1473-9
LID - 10.1002/nau.21116 [doi]
AB  - AIMS: To determine the prevalence, and sociodemographic and clinical factors
      associated with combined fecal and urinary incontinence in adults living in Pouso
      Alegre, Minas Gerais, Brazil. METHODS: This epidemiological study was approved by
      the Research Ethics Committee of the University of Sao Paulo School of Nursing.
      The participants were selected using a stratified cluster sampling design. The
      final sample consisted of 519 individuals, randomly selected, aged >/=18 years,
      living in 341 households in the urban area. Prevalence was adjusted for age and
      gender. RESULTS: The total prevalence of double incontinence was 3.0% (men 1.0%; 
      women 5.0%). The results of the final logistic regression model showed that
      changes in the habit of going out (odds ratio = 62.2; P < 0.001), duration of
      incontinence (odds ratio = 39.2; P < 0.001), female gender (odds ratio = 21.6; P 
      < 0.001), and widowhood (odds ratio = 19.4; P < 0.001) were associated with the
      presence of double incontinence. CONCLUSION: The study allowed a better
      understanding of the epidemiology of double incontinence and may contribute to
      the development of public policies and programs for primary and secondary
      prevention and treatment of double incontinence, at least at the municipal level.
CI  - Copyright (c) 2011 Wiley Periodicals, Inc.
FAU - Santos, Claudia Regina de Souza
AU  - Santos CR
AD  - Enterostomal Therapy Outpatient Clinic, Pouso Alegre City Public Health
      Department, Pouso Alegre, Brazil. claudiasantos8@hotmail.com
FAU - Santos, Vera Lucia Conceicao de Gouveia
AU  - Santos VL
LA  - eng
PT  - Journal Article
DEP - 20110808
PL  - United States
TA  - Neurourol Urodyn
JT  - Neurourology and urodynamics
JID - 8303326
SB  - IM
MH  - Adult
MH  - Brazil/epidemiology
MH  - Chi-Square Distribution
MH  - Cross-Sectional Studies
MH  - Fecal Incontinence/*epidemiology
MH  - Female
MH  - Health Surveys
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Prevalence
MH  - Risk Assessment
MH  - Risk Factors
MH  - Self Report
MH  - Socioeconomic Factors
MH  - Urban Health/*statistics & numerical data
MH  - Urinary Incontinence/*epidemiology
MH  - Young Adult
EDAT- 2011/08/10 06:00
MHDA- 2012/02/11 06:00
CRDT- 2011/08/10 06:00
PHST- 2010/12/19 00:00 [received]
PHST- 2011/03/02 00:00 [accepted]
PHST- 2011/08/10 06:00 [entrez]
PHST- 2011/08/10 06:00 [pubmed]
PHST- 2012/02/11 06:00 [medline]
AID - 10.1002/nau.21116 [doi]
PST - ppublish
SO  - Neurourol Urodyn. 2011 Nov;30(8):1473-9. doi: 10.1002/nau.21116. Epub 2011 Aug 8.


PMID- 21826599
OWN - NLM
STAT- MEDLINE
DCOM- 20111227
LR  - 20110809
IS  - 1672-0415 (Print)
IS  - 1672-0415 (Linking)
VI  - 17
IP  - 8
DP  - 2011 Aug
TI  - Principles of ethics review on traditional medicine and the practice of institute
      review board in China.
PG  - 631-4
LID - 10.1007/s11655-011-0820-1 [doi]
AB  - As one of the significant parts of medical science research in China, the
      research on Chinese medicine (CM) reflects the essence of healthcare tradition in
      the country both theoretically and clinically, and embodies the values of Chinese
      culture. Therefore, in the practice of ethics review on CM research protocols,
      besides abiding by the contemporary prevalent international principles and
      guidelines on bioethics, which emphasizes the scientific and bioethical value of 
      the study, we should also stress the CM theoretical background and relevant
      clinical experience in the framework of Chinese culture and values. In this
      paper, we went over the traits of CM clinical research and the experience from
      the practice of ethics review by the institution review board for bioethics, and 
      then attempted to summarize the key points for the bioethics review to CM
      researches in China, so as to serve as reference for the bioethics review to
      traditional and alternative medicine researches.
FAU - Wang, Xiao-yun
AU  - Wang XY
AD  - Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
FAU - Liang, Zhao-hui
AU  - Liang ZH
FAU - Huang, Hui-ling
AU  - Huang HL
FAU - Liang, Wei-xiong
AU  - Liang WX
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110809
PL  - China
TA  - Chin J Integr Med
JT  - Chinese journal of integrative medicine
JID - 101181180
SB  - IM
MH  - China
MH  - Drug Monitoring
MH  - Ethics Committees, Research/*ethics
MH  - *Ethics, Medical
MH  - Humans
MH  - Informed Consent
MH  - *Medicine, Chinese Traditional/adverse effects
EDAT- 2011/08/10 06:00
MHDA- 2011/12/28 06:00
CRDT- 2011/08/10 06:00
PHST- 2010/02/21 00:00 [received]
PHST- 2011/08/10 06:00 [entrez]
PHST- 2011/08/10 06:00 [pubmed]
PHST- 2011/12/28 06:00 [medline]
AID - 10.1007/s11655-011-0820-1 [doi]
PST - ppublish
SO  - Chin J Integr Med. 2011 Aug;17(8):631-4. doi: 10.1007/s11655-011-0820-1. Epub
      2011 Aug 9.


PMID- 21825997
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20220318
IS  - 1531-6998 (Electronic)
IS  - 1068-9508 (Linking)
VI  - 19
IP  - 5
DP  - 2011 Oct
TI  - Preventing complications in pediatric cochlear implantation.
PG  - 358-62
LID - 10.1097/MOO.0b013e32834a023b [doi]
AB  - PURPOSE OF REVIEW: This review addresses four key areas of controversy in the
      prevention of common complications of pediatric cochlear implant surgery:
      reducing meningitis risk, managing acute otitis media (AOM) in the cochlear
      implant population, assessing the optimum age for implanting a child to take
      advantage of the critical periods of language acquisition, and managing the
      social risk in defining ethical issues still surrounding cochlear implant in
      children. RECENT FINDINGS: Improved surgical techniques and the replacement of
      Prenvar-7 with Prenvar-13 significantly reduce the risk of cochlear implant
      related meningitis. AOM within 2 months of cochlear implant placement requires
      aggressive management to reduce the risk of complication. Tympanostomy tubes do
      not increase the risk of otitis media or meningitis and should be used when
      appropriate according to accepted AOM standards. Although the controversy over
      cochlear implant and the dissolution of Deaf Culture is decreasing, the use of
      cochlear implant in children remains an area for open dialogue between groups to 
      ensure children are treated appropriately. Discussions ought to be based on fact 
      and scientific evidence. SUMMARY: Although cochlear implants remain the gold
      standard for hearing restoration in children with severe to profound hearing
      loss, several issues remain controversial and are in need of further scientific
      exploration.
FAU - Melton, Myles F
AU  - Melton MF
AD  - Center for Hearing and Skull Base Surgery, Swedish Neuroscience Institute,
      Seattle, Washington 98122, USA.
FAU - Backous, Douglas D
AU  - Backous DD
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Otolaryngol Head Neck Surg
JT  - Current opinion in otolaryngology & head and neck surgery
JID - 9417024
SB  - IM
MH  - Age Factors
MH  - Child
MH  - Child, Preschool
MH  - *Cochlear Implantation/ethics
MH  - *Cochlear Implants
MH  - Humans
MH  - Infant
MH  - Language Development
MH  - Meningitis/prevention & control
MH  - Middle Ear Ventilation
MH  - Otitis Media/prevention & control
MH  - Postoperative Complications/*prevention & control
EDAT- 2011/08/10 06:00
MHDA- 2012/09/21 06:00
CRDT- 2011/08/10 06:00
PHST- 2011/08/10 06:00 [entrez]
PHST- 2011/08/10 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
AID - 10.1097/MOO.0b013e32834a023b [doi]
PST - ppublish
SO  - Curr Opin Otolaryngol Head Neck Surg. 2011 Oct;19(5):358-62. doi:
      10.1097/MOO.0b013e32834a023b.


PMID- 21825063
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20220316
IS  - 1098-5522 (Electronic)
IS  - 0019-9567 (Linking)
VI  - 79
IP  - 10
DP  - 2011 Oct
TI  - Retracted science and the retraction index.
PG  - 3855-9
LID - 10.1128/IAI.05661-11 [doi]
AB  - Articles may be retracted when their findings are no longer considered
      trustworthy due to scientific misconduct or error, they plagiarize previously
      published work, or they are found to violate ethical guidelines. Using a novel
      measure that we call the "retraction index," we found that the frequency of
      retraction varies among journals and shows a strong correlation with the journal 
      impact factor. Although retractions are relatively rare, the retraction process
      is essential for correcting the literature and maintaining trust in the
      scientific process.
FAU - Fang, Ferric C
AU  - Fang FC
FAU - Casadevall, Arturo
AU  - Casadevall A
LA  - eng
PT  - Editorial
DEP - 20110808
PL  - United States
TA  - Infect Immun
JT  - Infection and immunity
JID - 0246127
SB  - IM
CIN - Infect Immun. 2012 Mar;80(3):1300; author reply 1301. PMID: 22338040
MH  - Biomedical Research/standards
MH  - *Editorial Policies
MH  - *Journal Impact Factor
MH  - Plagiarism
MH  - Publishing/*standards
MH  - *Retraction of Publication as Topic
MH  - Scientific Misconduct
PMC - PMC3187237
EDAT- 2011/08/10 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/08/10 06:00
PHST- 2011/08/10 06:00 [entrez]
PHST- 2011/08/10 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - IAI.05661-11 [pii]
AID - 10.1128/IAI.05661-11 [doi]
PST - ppublish
SO  - Infect Immun. 2011 Oct;79(10):3855-9. doi: 10.1128/IAI.05661-11. Epub 2011 Aug 8.


PMID- 21824713
OWN - NLM
STAT- MEDLINE
DCOM- 20120328
LR  - 20111121
IS  - 1872-7654 (Electronic)
IS  - 0301-2115 (Linking)
VI  - 159
IP  - 1
DP  - 2011 Nov
TI  - Ovum donation: examining the new Israeli law.
PG  - 40-2
LID - 10.1016/j.ejogrb.2011.07.011 [doi]
AB  - Ovum donation affords countless couples that under natural circumstances would
      not be able to produce offspring the ability to carry out natural pregnancies.
      With advancements in biotechnology including egg collection and in vitro
      fertilization (IVF), physicians can now successfully implant fertilized embryos. 
      Due to Israel's tremendous involvement in IVF for its own citizens, the national 
      laws that govern egg donation are of great importance. On September 5th 2010, the
      Israeli Parliament (Knesset) passed a law that allows young women between the
      ages of 21 and 35 to donate their eggs for paid financial compensation. The new
      law allows infertile women between the ages of 18 and 54 to request egg donation 
      and IVF, which will partially be covered under state insurance plans. This
      article provides a description of the new Israeli law regulating ovum donation
      and the practical, moral and ethical debate surrounding the new system.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Gruenbaum, Benjamin F
AU  - Gruenbaum BF
AD  - Department of Medicine F, Soroka University Medical Center and Faculty of Health 
      Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
FAU - Pinchover, Zachary S
AU  - Pinchover ZS
FAU - Lunenfeld, Eitan
AU  - Lunenfeld E
FAU - Jotkowitz, Alan
AU  - Jotkowitz A
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110806
PL  - Ireland
TA  - Eur J Obstet Gynecol Reprod Biol
JT  - European journal of obstetrics, gynecology, and reproductive biology
JID - 0375672
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - Fraud/prevention & control
MH  - Humans
MH  - Infertility, Female/economics/therapy
MH  - Israel
MH  - *Legislation, Medical/economics/ethics
MH  - Middle Aged
MH  - National Health Programs/economics/ethics/legislation & jurisprudence
MH  - Oocyte Donation/economics/ethics/*legislation & jurisprudence
MH  - Religion and Medicine
MH  - Tissue Donors/ethics/legislation & jurisprudence
MH  - Young Adult
EDAT- 2011/08/10 06:00
MHDA- 2012/03/29 06:00
CRDT- 2011/08/10 06:00
PHST- 2011/01/26 00:00 [received]
PHST- 2011/05/07 00:00 [revised]
PHST- 2011/07/11 00:00 [accepted]
PHST- 2011/08/10 06:00 [entrez]
PHST- 2011/08/10 06:00 [pubmed]
PHST- 2012/03/29 06:00 [medline]
AID - S0301-2115(11)00432-5 [pii]
AID - 10.1016/j.ejogrb.2011.07.011 [doi]
PST - ppublish
SO  - Eur J Obstet Gynecol Reprod Biol. 2011 Nov;159(1):40-2. doi:
      10.1016/j.ejogrb.2011.07.011. Epub 2011 Aug 6.


PMID- 21824428
OWN - NLM
STAT- MEDLINE
DCOM- 20120626
LR  - 20211020
IS  - 1471-2261 (Electronic)
IS  - 1471-2261 (Linking)
VI  - 11
DP  - 2011 Aug 8
TI  - Serum neuron-specific enolase as predictor of outcome in comatose cardiac-arrest 
      survivors: a prospective cohort study.
PG  - 48
LID - 10.1186/1471-2261-11-48 [doi]
AB  - BACKGROUND: The prediction of neurological outcome in comatose patients after
      cardiac arrest has major ethical and socioeconomic implications. The purpose of
      this study was to assess the capability of serum neuron-specific enolase (NSE), a
      biomarker of hypoxic brain damage, to predict death or vegetative state in
      comatose cardiac-arrest survivors. METHODS: We conducted a prospective
      observational cohort study in one university hospital and one general hospital
      Intensive Care Unit (ICU). All consecutive patients who suffered cardiac arrest
      and were subsequently admitted from June 2007 to February 2009 were considered
      for inclusion in the study. Patients who died or awoke within the first 48 hours 
      of admission were excluded from the analysis. Patients were followed for 3 months
      or until death after cardiopulmonary resuscitation. The Cerebral Performance
      Categories scale (CPC) was used as the outcome measure; a CPC of 4-5 was regarded
      as a poor outcome, and a CPC of 1-3 a good outcome. Measurement of serum NSE was 
      performed at 24 h and at 72 h after the time of cardiac arrest using an enzyme
      immunoassay. Clinicians were blinded to NSE results. RESULTS: Ninety-seven
      patients were included. All patients were actively supported during the first
      days following cardiac arrest. Sixty-five patients (67%) underwent cooling after 
      resuscitation. At 3 months 72 (74%) patients had a poor outcome (CPC 4-5) and 25 
      (26%) a good outcome (CPC 1-3). The median and Interquartile Range [IQR] levels
      of NSE at 24 h and at 72 h were significantly higher in patients with poor
      outcomes: NSE at 24 h: 59.4 ng/mL [37-106] versus 28.8 ng/mL [18-41] (p <
      0.0001); and NSE at 72 h: 129.5 ng/mL [40-247] versus 15.7 ng/mL [12-19] (p <
      0.0001). The Receiver Operator Characteristics (ROC) curve for poor outcome for
      the highest observed NSE value for each patient determined a cut-off value for
      NSE of 97 ng/mL to predict a poor neurological outcome with a specificity of 100%
      [95% CI = 87-100] and a sensitivity of 49% [95% CI = 37-60]. However, an approach
      based on a combination of SSEPs, NSE and clinical-EEG tests allowed to increase
      the number of patients (63/72 (88%)) identified as having a poor outcome and for 
      whom intensive treatment could be regarded as futile. CONCLUSION: NSE levels
      measured early in the course of patient care for those who remained comatose
      after cardiac arrest were significantly higher in patients with outcomes of death
      or vegetative state. In addition, we provide a cut-off value for NSE (> 97 ng/mL)
      with 100% positive predictive value of poor outcome. Nevertheless, for decisions 
      concerning the continuation of treatment in this setting, we emphasize that an
      approach based on a combination of SSEPs, NSE and clinical EEG would be more
      accurate for identifying patients with a poor neurological outcome.
FAU - Daubin, Cedric
AU  - Daubin C
AD  - Department of Medical Intensive Care, CHU de Caen, Caen, F-14000, France.
      daubin-c@chu-caen.fr
FAU - Quentin, Charlotte
AU  - Quentin C
FAU - Allouche, Stephane
AU  - Allouche S
FAU - Etard, Olivier
AU  - Etard O
FAU - Gaillard, Cathy
AU  - Gaillard C
FAU - Seguin, Amelie
AU  - Seguin A
FAU - Valette, Xavier
AU  - Valette X
FAU - Parienti, Jean-Jacques
AU  - Parienti JJ
FAU - Prevost, Fabrice
AU  - Prevost F
FAU - Ramakers, Michel
AU  - Ramakers M
FAU - Terzi, Nicolas
AU  - Terzi N
FAU - Charbonneau, Pierre
AU  - Charbonneau P
FAU - du Cheyron, Damien
AU  - du Cheyron D
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20110808
PL  - England
TA  - BMC Cardiovasc Disord
JT  - BMC cardiovascular disorders
JID - 100968539
RN  - 0 (Biomarkers)
RN  - EC 4.2.1.11 (Phosphopyruvate Hydratase)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - Cohort Studies
MH  - Coma/*diagnosis/*enzymology/mortality
MH  - Female
MH  - Heart Arrest/*diagnosis/*enzymology/mortality
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Phosphopyruvate Hydratase/*blood
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Survival Rate/trends
MH  - Treatment Outcome
PMC - PMC3161948
EDAT- 2011/08/10 06:00
MHDA- 2012/06/27 06:00
CRDT- 2011/08/10 06:00
PHST- 2011/02/25 00:00 [received]
PHST- 2011/08/08 00:00 [accepted]
PHST- 2011/08/10 06:00 [entrez]
PHST- 2011/08/10 06:00 [pubmed]
PHST- 2012/06/27 06:00 [medline]
AID - 1471-2261-11-48 [pii]
AID - 10.1186/1471-2261-11-48 [doi]
PST - epublish
SO  - BMC Cardiovasc Disord. 2011 Aug 8;11:48. doi: 10.1186/1471-2261-11-48.


PMID- 21824311
OWN - NLM
STAT- MEDLINE
DCOM- 20111121
LR  - 20110809
IS  - 1742-6723 (Electronic)
IS  - 1742-6723 (Linking)
VI  - 23
IP  - 4
DP  - 2011 Aug
TI  - Ethical issues in resuscitation of the newborn infant. ARC and NZRC Guideline
      2010.
PG  - 450-1
LID - 10.1111/j.1742-6723.2011.01442_17.x [doi]
CN  - Australian Resuscitation Council
CN  - New Zealand Resuscitation Council
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Emerg Med Australas
JT  - Emergency medicine Australasia : EMA
JID - 101199824
SB  - IM
MH  - Australia
MH  - *Bioethical Issues
MH  - Cardiopulmonary Resuscitation/*ethics/methods
MH  - Emergency Medicine/*ethics
MH  - Humans
MH  - *Infant, Newborn
MH  - Infant, Premature
MH  - Medical Futility/ethics
MH  - Neonatology/*ethics
MH  - New Zealand
EDAT- 2011/08/10 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/08/10 06:00
PHST- 2011/08/10 06:00 [entrez]
PHST- 2011/08/10 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1111/j.1742-6723.2011.01442_17.x [doi]
PST - ppublish
SO  - Emerg Med Australas. 2011 Aug;23(4):450-1. doi:
      10.1111/j.1742-6723.2011.01442_17.x.


PMID- 21824302
OWN - NLM
STAT- MEDLINE
DCOM- 20111121
LR  - 20110809
IS  - 1742-6723 (Electronic)
IS  - 1742-6723 (Linking)
VI  - 23
IP  - 4
DP  - 2011 Aug
TI  - Introduction to resuscitation of the newborn infant. ARC and NZRC Guideline 2010.
PG  - 419-23
LID - 10.1111/j.1742-6723.2011.01442_8.x [doi]
AB  - * Introduction to Resuscitation of the Newborn Infant. ARC and NZRC Guideline
      2010 * Planning for Neonatal Resuscitation and Identification of the Newborn
      Infant at Risk. ARC and NZRC Guideline 2010 * Assessment of the Newborn Infant.
      ARC and NZRC Guideline 2010 * Airway Management and Mask Ventilation of the
      Newborn Infant. ARC and NZRC Guideline 2010 * Tracheal Intubation and Ventilation
      of the Newborn Infant. ARC and NZRC Guideline 2010 * Chest Compressions during
      Resuscitation of the Newborn Infant. ARC and NZRC Guideline 2010 * Medication or 
      Fluids for the Resuscitation of the Newborn Infant. ARC and NZRC Guideline 2010 *
      The Resuscitation of the Newborn Infant in Special Circumstances. ARC and NZRC
      Guideline 2010 * After the Resuscitation of a Newborn Infant. ARC and NZRC
      Guideline 2010 * Ethical Issues in Resuscitation of the Newborn Infant. ARC and
      NZRC Guideline 2010.
CI  - (c) 2011 The Authors. EMA (c) 2011 Australasian College for Emergency Medicine
      and Australasian Society for Emergency Medicine.
CN  - Australian Resuscitation Council
CN  - New Zealand Resuscitation Council
LA  - eng
PT  - Journal Article
PT  - Practice Guideline
PL  - Australia
TA  - Emerg Med Australas
JT  - Emergency medicine Australasia : EMA
JID - 101199824
SB  - IM
MH  - Australia
MH  - Cardiopulmonary Resuscitation/*methods
MH  - Emergency Medical Services/*methods
MH  - Female
MH  - Humans
MH  - *Infant, Newborn
MH  - Male
MH  - Neonatology/methods
MH  - New Zealand
EDAT- 2011/08/10 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/08/10 06:00
PHST- 2011/08/10 06:00 [entrez]
PHST- 2011/08/10 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1111/j.1742-6723.2011.01442_8.x [doi]
PST - ppublish
SO  - Emerg Med Australas. 2011 Aug;23(4):419-23. doi:
      10.1111/j.1742-6723.2011.01442_8.x.


PMID- 21824227
OWN - NLM
STAT- MEDLINE
DCOM- 20111220
LR  - 20191210
IS  - 1478-5153 (Electronic)
IS  - 1362-1017 (Linking)
VI  - 16
IP  - 5
DP  - 2011 Sep-Oct
TI  - The ventilator care bundle and its impact on ventilator-associated pneumonia: a
      review of the evidence.
PG  - 222-34
LID - 10.1111/j.1478-5153.2010.00430.x [doi]
AB  - AIMS AND OBJECTIVES: The aim of this review was to critically analyse recent
      research that has investigated ventilator care bundle (VCB) use, with the
      objective of analysing its impact on ventilator-associated pneumonia (VAP)
      outcomes. BACKGROUND: The VCB is a group of four evidence-based procedures, which
      when clustered together and implemented as an 'all or nothing' strategy, may
      result in substantial clinical outcome improvement. VAP is a nosocomial lung
      infection associated with endotracheal tube use in ventilated patients. Since the
      VCB was introduced there have been several studies that have reported significant
      VAP rate reductions. SEARCH STRATEGY: A comprehensive search for research,
      published between 2004 and 2009, was conducted using Medline and PubMed. Key
      words were used to identify English language studies reporting VCB implementation
      within adult intensive care units (ICU) and associated clinical outcomes. Studies
      that implemented bundle variations that did not include all four elements were
      excluded. CONCLUSIONS: Because of the limitations of the observational designs
      used in the studies retrieved, a definitive causal relationship between VCB use
      and VAP reduction cannot be stated. However, the evidence to date is strongly
      indicative of a positive association. Several studies reported the use of
      additional VCB elements. In these cases it is difficult to establish which
      elements are related to the measured outcomes. Further research is recommended to
      establish baseline outcome measures using the four-element VCB, before adding
      further processes singly, as well as research investigating the effect of audit
      and feedback on VCB compliance and its effect on clinical outcomes. RELEVANCE TO 
      CLINICAL PRACTICE: A reduction in VAP is associated with VCB use. The evidence to
      date, whilst not at the highest experimental level, is at the highest ethically
      permissible level. In the absence of contradictory research, the current evidence
      suggests that use of the VCB represents best practice for all eligible adult
      ventilated patients in ICU.
CI  - (c) 2011 The Authors. Nursing in Critical Care (c) 2011 British Association of
      Critical Care Nurses.
FAU - Lawrence, Petra
AU  - Lawrence P
AD  - Nursing Research & Practice Development Centre, The Prince Charles Hospital,
      Brisbane, Australia.
FAU - Fulbrook, Paul
AU  - Fulbrook P
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Nurs Crit Care
JT  - Nursing in critical care
JID - 9808649
MH  - Adult
MH  - *Evidence-Based Medicine
MH  - Humans
MH  - Intensive Care Units/statistics & numerical data
MH  - *Outcome Assessment, Health Care
MH  - Pneumonia, Ventilator-Associated/*prevention & control
MH  - Respiration, Artificial/*methods
EDAT- 2011/08/10 06:00
MHDA- 2011/12/21 06:00
CRDT- 2011/08/10 06:00
PHST- 2011/08/10 06:00 [entrez]
PHST- 2011/08/10 06:00 [pubmed]
PHST- 2011/12/21 06:00 [medline]
AID - 10.1111/j.1478-5153.2010.00430.x [doi]
PST - ppublish
SO  - Nurs Crit Care. 2011 Sep-Oct;16(5):222-34. doi: 10.1111/j.1478-5153.2010.00430.x.


PMID- 21824219
OWN - NLM
STAT- MEDLINE
DCOM- 20120116
LR  - 20110928
IS  - 1440-1843 (Electronic)
IS  - 1323-7799 (Linking)
VI  - 16
IP  - 7
DP  - 2011 Oct
TI  - Heaves, an asthma-like disease of horses.
PG  - 1027-46
LID - 10.1111/j.1440-1843.2011.02033.x [doi]
AB  - Animal models have been developed to investigate specific components of asthmatic
      airway inflammation, hyper-responsiveness or remodelling. However, all of these
      aspects are rarely observed in the same animal. Heaves is a naturally occurring
      disease of horses that combines these features. It is characterized by stable
      dust-induced inflammation, bronchospasm and remodelling. The evaluation of horses
      during well-controlled natural antigen exposure and avoidance in experimental
      settings allows the study of disease mechanisms in the asymptomatic and
      symptomatic stages, an approach rarely feasible in humans. Also, the disease can 
      be followed over several years to observe the cumulative effect of repeated
      episodes of clinical exacerbation or to evaluate long-term treatment, contrasting
      most murine asthma models. This model has shown complex gene and environment
      interactions, the involvement of both innate and adaptive responses to
      inflammation, and the contribution of bronchospasm and tissue remodelling to
      airway obstruction, all occurring in a natural setting. Similarities with the
      human asthmatic airways are well described and the model is currently being used 
      to evaluate airway remodelling and its reversibility in ways that are not
      possible in people for ethical reasons. Tools including antibodies, recombinant
      proteins or gene arrays, as well as methods for sampling tissues and assessing
      lung function in the horse are constantly evolving to facilitate the study of
      this animal model. Research perspectives that can be relevant to asthma include
      the role of neutrophils in airway inflammation and their response to
      corticosteroids, systemic response to pulmonary inflammation, and maintaining
      athletic capacities with early intervention.
CI  - (c) 2011 The Authors. Respirology (c) 2011 Asian Pacific Society of Respirology.
FAU - Leclere, Mathilde
AU  - Leclere M
AD  - Department of Clinical Sciences, Faculty of Veterinary Medicine, Universite de
      Montreal, St-Hyacinthe, Canada.
FAU - Lavoie-Lamoureux, Anouk
AU  - Lavoie-Lamoureux A
FAU - Lavoie, Jean-Pierre
AU  - Lavoie JP
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Australia
TA  - Respirology
JT  - Respirology (Carlton, Vic.)
JID - 9616368
RN  - 0 (Dust)
SB  - IM
MH  - Airway Remodeling/*immunology
MH  - Animals
MH  - Asthma/*immunology/physiopathology
MH  - Bronchial Hyperreactivity/*immunology
MH  - Cell Proliferation
MH  - Disease Models, Animal
MH  - Dust/*immunology
MH  - Horse Diseases/*immunology/physiopathology
MH  - Horses
MH  - Humans
MH  - Neutrophils/*immunology
EDAT- 2011/08/10 06:00
MHDA- 2012/01/17 06:00
CRDT- 2011/08/10 06:00
PHST- 2011/08/10 06:00 [entrez]
PHST- 2011/08/10 06:00 [pubmed]
PHST- 2012/01/17 06:00 [medline]
AID - 10.1111/j.1440-1843.2011.02033.x [doi]
PST - ppublish
SO  - Respirology. 2011 Oct;16(7):1027-46. doi: 10.1111/j.1440-1843.2011.02033.x.


PMID- 21824195
OWN - NLM
STAT- MEDLINE
DCOM- 20120116
LR  - 20151119
IS  - 1600-0625 (Electronic)
IS  - 0906-6705 (Linking)
VI  - 20
IP  - 10
DP  - 2011 Oct
TI  - Shortened treatment duration of glucocorticoid-induced skin atrophy in rats.
PG  - 853-5
LID - 10.1111/j.1600-0625.2011.01341.x [doi]
AB  - Glucocorticoids (GCs) belong to the most widely used anti-inflammatory drugs at
      all. However, their topical use is limited by their side effect potential, with
      skin atrophy being the most prominent one. Thus, determining the atrophogenic
      potential of novel compounds is of importance for drug development. Currently,
      the most frequently performed model in the base and pharmaceutical research is
      the hr/hr rat model of GC-induced skin atrophy that lasts for 19 days. In this
      study, we analysed statistically skin atrophy experiments retrospectively to
      ascertain (i) the earliest time-point, at which skin atrophy is significantly
      induced; and (ii) whether the differences between the GC treatment groups change 
      until the end of the experiment. We show here that the treatment duration of rat 
      skin atrophy models might be reduced to 5 days for economical and ethical
      reasons.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Schoepe, Stefanie
AU  - Schoepe S
FAU - Vonk, Richardus
AU  - Vonk R
FAU - Schacke, Heike
AU  - Schacke H
FAU - Zollner, Thomas M
AU  - Zollner TM
FAU - Asadullah, Khusru
AU  - Asadullah K
FAU - Rose, Lars
AU  - Rose L
LA  - eng
PT  - Letter
DEP - 20110808
PL  - Denmark
TA  - Exp Dermatol
JT  - Experimental dermatology
JID - 9301549
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Glucocorticoids)
RN  - 0 (Pregnadienediols)
RN  - 04201GDN4R (Mometasone Furoate)
RN  - ADN79D536H (Clobetasol)
RN  - X4W7ZR7023 (Methylprednisolone)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/adverse effects
MH  - Atrophy/chemically induced/pathology
MH  - Clobetasol/adverse effects
MH  - Disease Models, Animal
MH  - Glucocorticoids/*adverse effects
MH  - Linear Models
MH  - Methylprednisolone/adverse effects
MH  - Mometasone Furoate
MH  - Pregnadienediols/adverse effects
MH  - Rats
MH  - Rats, Hairless
MH  - Skin/*drug effects/*pathology
MH  - Time Factors
EDAT- 2011/08/10 06:00
MHDA- 2012/01/17 06:00
CRDT- 2011/08/10 06:00
PHST- 2011/08/10 06:00 [entrez]
PHST- 2011/08/10 06:00 [pubmed]
PHST- 2012/01/17 06:00 [medline]
AID - 10.1111/j.1600-0625.2011.01341.x [doi]
PST - ppublish
SO  - Exp Dermatol. 2011 Oct;20(10):853-5. doi: 10.1111/j.1600-0625.2011.01341.x. Epub 
      2011 Aug 8.


PMID- 21824018
OWN - NLM
STAT- MEDLINE
DCOM- 20120112
LR  - 20110819
IS  - 1464-5351 (Electronic)
IS  - 1369-1058 (Linking)
VI  - 13
IP  - 9
DP  - 2011 Oct
TI  - Perceptions about safety and risks in gender-based violence research:
      implications for the ethics review process.
PG  - 1091-102
LID - 10.1080/13691058.2011.604429 [doi]
AB  - Does research on gender-based violence (GBV) pose greater than minimal risk to
      researchers and participants? This question needs to be understood particularly
      in light of hesitancy by Institutional Review Boards to approve research on GBV. 
      The safety and risks of doing GBV studies and the implications for the ethical
      review process have not been a focus of much research. This qualitative study
      collected data through in-depth interviews with 12 experienced GBV researchers
      from various countries and a desk review. This paper explores researchers'
      interpretation of and meanings of the safety recommendations as provided in the
      WHO guidelines and whether there is empirical evidence on the presence of risks
      and safety concerns unique to GBV research. Informants raised a number of safety 
      concerns about GBV research, yet in the interviews there were very few examples
      of problems having occurred, possibly because of the precautions applied. This
      paper argues that the notion that GBV studies carry greater than minimal risk
      when ethics precautions are followed is based on speculation, not evidence. It
      highlights the need for empirical evidence to support assertions of risk in
      research.
FAU - Sikweyiya, Yandisa
AU  - Sikweyiya Y
AD  - Gender and Health Research Unit, South African Medical Research Council,
      Pretoria, South Africa. yandisa.sikweyiya@mrc.ac.za
FAU - Jewkes, Rachel
AU  - Jewkes R
LA  - eng
PT  - Journal Article
DEP - 20110809
PL  - England
TA  - Cult Health Sex
JT  - Culture, health & sexuality
JID - 100883416
SB  - IM
MH  - Domestic Violence/*ethics/prevention & control/statistics & numerical data
MH  - *Ethics, Medical
MH  - Female
MH  - *Gender Identity
MH  - Health Services Research/*ethics/methods
MH  - Health Surveys
MH  - Humans
MH  - Interview, Psychological
MH  - Male
MH  - *Perception
MH  - Psychometrics
MH  - Qualitative Research
MH  - Risk
MH  - Sex Factors
MH  - United States
EDAT- 2011/08/10 06:00
MHDA- 2012/01/13 06:00
CRDT- 2011/08/10 06:00
PHST- 2011/08/10 06:00 [entrez]
PHST- 2011/08/10 06:00 [pubmed]
PHST- 2012/01/13 06:00 [medline]
AID - 10.1080/13691058.2011.604429 [doi]
PST - ppublish
SO  - Cult Health Sex. 2011 Oct;13(9):1091-102. doi: 10.1080/13691058.2011.604429. Epub
      2011 Aug 9.


PMID- 21823368
OWN - NLM
STAT- MEDLINE
DCOM- 20110823
LR  - 20190319
IS  - 0310-057X (Print)
IS  - 0310-057X (Linking)
VI  - 39
IP  - 4
DP  - 2011 Jul
TI  - Ethics and evidence.
PG  - 539-40
FAU - Bradley, J P
AU  - Bradley JP
LA  - eng
PT  - Comment
PT  - Editorial
PL  - United States
TA  - Anaesth Intensive Care
JT  - Anaesthesia and intensive care
JID - 0342017
SB  - IM
CON - Anaesth Intensive Care. 2011 Jul;39(4):659-65. PMID: 21823386
MH  - Australia
MH  - Critical Care
MH  - Decompressive Craniectomy/*ethics/*methods
MH  - *Evidence-Based Medicine
MH  - Humans
MH  - Informed Consent
MH  - Intracranial Hypertension/physiopathology/*surgery
MH  - Intracranial Pressure/physiology
MH  - Multicenter Studies as Topic
EDAT- 2011/08/10 06:00
MHDA- 2011/08/24 06:00
CRDT- 2011/08/10 06:00
PHST- 2011/08/10 06:00 [entrez]
PHST- 2011/08/10 06:00 [pubmed]
PHST- 2011/08/24 06:00 [medline]
AID - 20110388 [pii]
AID - 10.1177/0310057X1103900403 [doi]
PST - ppublish
SO  - Anaesth Intensive Care. 2011 Jul;39(4):539-40. doi: 10.1177/0310057X1103900403.


PMID- 21823364
OWN - NLM
STAT- MEDLINE
DCOM- 20110906
LR  - 20171116
IS  - 2067-2993 (Print)
IS  - 2067-2993 (Linking)
VI  - 60
IP  - 2
DP  - 2011 Apr-Jun
TI  - School-based smoking prevention programmes: ethical aspects.
PG  - 107-10
AB  - School-based health education has the potential to inform and educate young
      people, in order to promote healthy behaviours among them, which will help to
      prevent diseases and social problems. The present study gives an overview of
      several ethical issues which must be considered in different phases of
      school-based smoking prevention programs. This will help health educators, public
      health professionals and researchers in their activity of health education in
      schools. The ethical issues must be taken into consideration during all the
      activities and refer to the involvement of officials, schools, parents, young
      people who participate into the program, authors and persons/institutions
      responsible with the implementation, evaluation or funding of the programs. The
      application into practice of these ethical principles, influence the quality of
      the health education, its acceptability BY the target group and the correctness
      of results. Also, it prevents possible problems and misunderstandings between
      persons and institutions involved in the health education and smoking prevention 
      process, which could seriously affect and even destroy implementation of such
      health education activities.
FAU - Lotrean, Lucia Maria
AU  - Lotrean LM
AD  - Department of Hygiene, University of Medicine and Pharmacy "Iuliu Hatieganu",
      Cluj-Napoca, Romania. llotrean@umfcluj.ro
FAU - Trofor, Antigona
AU  - Trofor A
FAU - Mihaltan, Florin
AU  - Mihaltan F
FAU - Santillan, Edna Arillo
AU  - Santillan EA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Romania
TA  - Pneumologia
JT  - Pneumologia (Bucharest, Romania)
JID - 100941067
SB  - IM
MH  - Adolescent
MH  - Adolescent Behavior
MH  - Family
MH  - Government Agencies/ethics
MH  - *Health Education/methods
MH  - *Health Promotion
MH  - Humans
MH  - Informed Consent
MH  - Romania
MH  - School Health Services/*ethics/legislation & jurisprudence
MH  - *Schools
MH  - Smoking/adverse effects
MH  - *Smoking Prevention
EDAT- 2011/08/10 06:00
MHDA- 2011/09/07 06:00
CRDT- 2011/08/10 06:00
PHST- 2011/08/10 06:00 [entrez]
PHST- 2011/08/10 06:00 [pubmed]
PHST- 2011/09/07 06:00 [medline]
PST - ppublish
SO  - Pneumologia. 2011 Apr-Jun;60(2):107-10.


PMID- 21814118
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20131121
IS  - 1529-8809 (Electronic)
IS  - 0022-5282 (Linking)
VI  - 71
IP  - 2 Suppl 1
DP  - 2011 Aug
TI  - Poly-N-acetyl glucosamine fibers activate bone regeneration in a rabbit femur
      injury model.
PG  - S194-6
LID - 10.1097/TA.0b013e3182258799 [doi]
AB  - BACKGROUND: The purpose of this study was to evaluate the ability of a membrane
      material, consisting only of short poly-N-acetyl glucosamine (sNAG) nanofibers,
      to regenerate bone tissue after implantation into circular holes in the rabbit
      femur. METHODS: Three circular holes were created in the femurs of five male New 
      Zealand white rabbits. The holes were approximately 2.0 mm in diameter. Three
      holes in the left femur were implanted with the comparative control substance
      (Bone Wax; Ethicon, Inc.); three holes in the right femur were implanted with the
      sNAG membrane test article. Animals were killed 4 weeks after surgery, and
      macroscopic evaluation of the implant sites was made. Hematoxylin and eosin
      histology was performed on both control and test sites. RESULTS: All control
      (bone wax) sites had visible holes (defects) at the 28-day end point of the study
      and showed no evidence of new bone formation. All the 15 sNAG test sites were
      found to have new bone tissue present in the bone hole defects. Hematoxylin and
      eosin histology of the sNAG-treated test sites showed the presence of
      osteoblasts, osteocytes, and trabecula of new bone formation at the 28-day end
      point of the study. CONCLUSIONS: The sNAG membrane test material activated the
      regeneration of new bone tissue in a rabbit femur bone model after 28 days of
      implantation, whereas the control bone wax material did not.
FAU - Muise-Helmericks, Robin C
AU  - Muise-Helmericks RC
AD  - Department of Regenerative Medicine and Cell Biology, Medical University of South
      Carolina, Charleston, South Carolina, USA.
FAU - Demcheva, Marina
AU  - Demcheva M
FAU - Vournakis, John N
AU  - Vournakis JN
FAU - Seth, Arun
AU  - Seth A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Trauma
JT  - The Journal of trauma
JID - 0376373
RN  - 0 (poly-N-acetyl glucosamine)
RN  - V956696549 (Acetylglucosamine)
SB  - IM
MH  - Acetylglucosamine/*pharmacology
MH  - Animals
MH  - Bone Regeneration/*drug effects
MH  - Disease Models, Animal
MH  - Femur/*drug effects/*injuries/pathology
MH  - Male
MH  - Nanofibers
MH  - Osteoblasts/drug effects/pathology
MH  - Rabbits
EDAT- 2011/08/10 06:00
MHDA- 2011/10/25 06:00
CRDT- 2011/08/05 06:00
PHST- 2011/08/05 06:00 [entrez]
PHST- 2011/08/10 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
AID - 10.1097/TA.0b013e3182258799 [doi]
AID - 00005373-201108001-00008 [pii]
PST - ppublish
SO  - J Trauma. 2011 Aug;71(2 Suppl 1):S194-6. doi: 10.1097/TA.0b013e3182258799.


PMID- 21823146
OWN - NLM
STAT- MEDLINE
DCOM- 20120116
LR  - 20171116
IS  - 1097-0258 (Electronic)
IS  - 0277-6715 (Linking)
VI  - 30
IP  - 24
DP  - 2011 Oct 30
TI  - Optimal response-adaptive randomized designs for multi-armed survival trials.
PG  - 2890-910
LID - 10.1002/sim.4331 [doi]
AB  - We considered design issues for multiple treatment arms in survival intervention 
      trials and used optimal design theory to allocate patients adaptively in such
      trials. We proposed three types of optimal designs: one ensures that we have the 
      most precise estimates of the treatment effects, another guarantees that we have 
      the minimal sample size subject to user-specified allocation ratio assignments
      among treatment arms, and the third ensures that the design has minimal total
      hazard for the cohort. The latter two types of optimal designs are also subject
      to user-specified power constraints for testing contrasts among treatment
      effects. The operating characteristics of these optimal designs along with
      balanced designs are compared theoretically and by simulation, including their
      robustness properties with respect to model misspecifications. Our results show
      that the proposed optimal designs are frequently unbalanced and that they are
      generally more efficient and more ethical than the popular balanced designs. We
      also apply our response-adaptive allocation strategy to redesign a three-arm head
      and neck cancer trial and make comparisons.
CI  - Copyright (c) 2011 John Wiley & Sons, Ltd.
FAU - Sverdlov, Oleksandr
AU  - Sverdlov O
AD  - Bristol-Myers Squibb, Route 206 and Province Line Road, Princeton, NJ 08543, USA.
      alex.sverdlov@bms.com
FAU - Tymofyeyev, Yevgen
AU  - Tymofyeyev Y
FAU - Wong, Weng Kee
AU  - Wong WK
LA  - eng
PT  - Journal Article
DEP - 20110808
PL  - England
TA  - Stat Med
JT  - Statistics in medicine
JID - 8215016
SB  - IM
MH  - Bias
MH  - Biostatistics
MH  - Clinical Trials, Phase III as Topic/statistics & numerical data
MH  - Combined Modality Therapy
MH  - Computer Simulation
MH  - Head and Neck Neoplasms/drug therapy/radiotherapy
MH  - Humans
MH  - Models, Statistical
MH  - Nonlinear Dynamics
MH  - Random Allocation
MH  - Randomized Controlled Trials as Topic/*statistics & numerical data
MH  - Sample Size
EDAT- 2011/08/09 06:00
MHDA- 2012/01/17 06:00
CRDT- 2011/08/09 06:00
PHST- 2010/09/06 00:00 [received]
PHST- 2011/06/14 00:00 [accepted]
PHST- 2011/08/09 06:00 [entrez]
PHST- 2011/08/09 06:00 [pubmed]
PHST- 2012/01/17 06:00 [medline]
AID - 10.1002/sim.4331 [doi]
PST - ppublish
SO  - Stat Med. 2011 Oct 30;30(24):2890-910. doi: 10.1002/sim.4331. Epub 2011 Aug 8.


PMID- 21822934
OWN - NLM
STAT- MEDLINE
DCOM- 20120521
LR  - 20211020
IS  - 1432-1459 (Electronic)
IS  - 0340-5354 (Linking)
VI  - 259
IP  - 2
DP  - 2012 Feb
TI  - Challenges of clinical trial design when there is lack of clinical equipoise: use
      of a response-conditional crossover design.
PG  - 348-52
LID - 10.1007/s00415-011-6200-0 [doi]
AB  - Clinical equipoise is widely accepted as the basis of ethics in clinical research
      and requires investigators to be uncertain of the relative therapeutic merits of 
      trial comparators. When clinical equipoise is in question, innovative trial
      designs are needed to reduce ethical tension while satisfying regulators'
      requirements. We report a novel response-conditional crossover study design used 
      in a Phase 3, randomized, double-blind, placebo-controlled clinical trial of
      intravenous 10% caprylate-chromatography purified immunoglobulin for chronic
      inflammatory demyelinating polyradiculoneuropathy. During the initial 24-week
      period, patients crossed over to the alternative treatment at the first sign of
      deterioration or if they failed to improve or were unable to maintain improvement
      at any time after 6 weeks. This trial design addressed concerns about lack of
      equipoise raised by physicians interested in trial participation and proved
      acceptable to regulatory authorities. The trial design may be applicable to other
      studies where clinical equipoise is in question.
FAU - Deng, Chunqin
AU  - Deng C
AD  - Grifols Inc. (formerly Talecris Biotherapeutics), 79 TW Alexander Drive, Research
      Triangle Park, Durham, NC 27709, USA. CQ.Deng@Talecris.com
FAU - Hanna, Kim
AU  - Hanna K
FAU - Bril, Vera
AU  - Bril V
FAU - Dalakas, Marinos C
AU  - Dalakas MC
FAU - Donofrio, Peter
AU  - Donofrio P
FAU - van Doorn, Pieter A
AU  - van Doorn PA
FAU - Hartung, Hans-Peter
AU  - Hartung HP
FAU - Merkies, Ingemar S J
AU  - Merkies IS
LA  - eng
PT  - Clinical Trial, Phase III
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20110807
PL  - Germany
TA  - J Neurol
JT  - Journal of neurology
JID - 0423161
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Immunologic Factors)
SB  - IM
MH  - *Cross-Over Studies
MH  - Double-Blind Method
MH  - Humans
MH  - Immunoglobulins, Intravenous/*therapeutic use
MH  - Immunologic Factors/*therapeutic use
MH  - Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/*drug therapy
MH  - *Research Design
MH  - *Therapeutic Equipoise
PMC - PMC3268968
EDAT- 2011/08/09 06:00
MHDA- 2012/05/23 06:00
CRDT- 2011/08/09 06:00
PHST- 2011/05/25 00:00 [received]
PHST- 2011/07/21 00:00 [accepted]
PHST- 2011/07/18 00:00 [revised]
PHST- 2011/08/09 06:00 [entrez]
PHST- 2011/08/09 06:00 [pubmed]
PHST- 2012/05/23 06:00 [medline]
AID - 10.1007/s00415-011-6200-0 [doi]
PST - ppublish
SO  - J Neurol. 2012 Feb;259(2):348-52. doi: 10.1007/s00415-011-6200-0. Epub 2011 Aug
      7.


PMID- 21822635
OWN - NLM
STAT- MEDLINE
DCOM- 20120522
LR  - 20220408
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 23
IP  - 4
DP  - 2011 Dec
TI  - Emotions and ethical considerations of women undergoing IVF-treatments.
PG  - 281-93
LID - 10.1007/s10730-011-9159-4 [doi]
AB  - Women who suffer from fertility issues often use in vitro fertilization (IVF) to 
      realize their wish to have children. However, IVF has its own set of strict
      administration rules that leave the women physically and emotionally exhausted.
      Feeling alienated and frustrated, many IVF users turn to internet IVF-centered
      forums to share their stories and to find information and support. Based on the
      observation of Dutch and Greek IVF forums and a selection of 109 questionnaires
      from Dutch and Greek IVF forum users, we investigate the reasons why users of IVF
      participate in online communities centered on IVF, their need for emotional
      expression and support, and how they experience and use the information and
      support they receive through their participation in the online community. We
      argue that the emotional concerns expressed in such forums should be taken into
      account by health care ethics committees for IVF-related matters in order to
      promote more patient-oriented care and support for women going through IVF.
FAU - Kaliarnta, Sofia
AU  - Kaliarnta S
AD  - Philosophy Department, Faculty of Technology, Policy and Management, Delft
      University of Technology, The Netherlands. S.Kaliarnta@tudelft.nl
FAU - Nihlen-Fahlquist, Jessica
AU  - Nihlen-Fahlquist J
FAU - Roeser, Sabine
AU  - Roeser S
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - *Emotions
MH  - Female
MH  - Fertilization in Vitro/*ethics/methods/*psychology
MH  - Humans
MH  - Stress, Psychological
MH  - Surveys and Questionnaires
PMC - PMC3258403
EDAT- 2011/08/09 06:00
MHDA- 2012/05/23 06:00
CRDT- 2011/08/09 06:00
PHST- 2011/08/09 06:00 [entrez]
PHST- 2011/08/09 06:00 [pubmed]
PHST- 2012/05/23 06:00 [medline]
AID - 10.1007/s10730-011-9159-4 [doi]
PST - ppublish
SO  - HEC Forum. 2011 Dec;23(4):281-93. doi: 10.1007/s10730-011-9159-4.


PMID- 21822634
OWN - NLM
STAT- MEDLINE
DCOM- 20120522
LR  - 20211020
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 23
IP  - 4
DP  - 2011 Dec
TI  - Inclusive consultation: a hermeneutical approach to ethical deliberation in the
      clinical setting.
PG  - 295-304
LID - 10.1007/s10730-011-9161-x [doi]
AB  - The problem of ethical consultations in the clinical setting should be
      reasonable, but it cannot be reduced to reason and philosophical theory alone. I 
      will argue that emotions are constitutively and discursively relevant features of
      the evaluative experience of persons. Ethical consultations should include
      emotions. Emotions like shame and guilt are complex and learned reactions of
      persons, which form one basis of ethical reflection. I argue that ethical
      consultation can rely neither on a strict theory or method nor on a philosophical
      theory that is external to the situational triggers of consultations in the
      clinical setting. Emotions are one essential trigger of the need for ethical
      consultations. I will show that methodologically consultation depends on
      understanding the evaluative experiences of persons who cooperate in the clinical
      setting. Moreover, such evaluative experiences includes emotive reactions as well
      as reason. My conclusion is that ethical consultation in the clinical setting
      needs a conceptual understanding of epistemic, justificatory and methodological
      inclusiveness. This circumstance can be summarized: ethical consultations need
      the ongoing development of a moral hermeneutics of clinical consultation.
FAU - Vieth, Andreas
AU  - Vieth A
AD  - University of Duisburg-Essen, Essen, Germany. andreas.vieth@uni-due.de
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - Decision Making/*ethics
MH  - Delivery of Health Care
MH  - *Emotions
MH  - Ethics Committees, Clinical
MH  - *Ethics Consultation
MH  - Humans
EDAT- 2011/08/09 06:00
MHDA- 2012/05/23 06:00
CRDT- 2011/08/09 06:00
PHST- 2011/08/09 06:00 [entrez]
PHST- 2011/08/09 06:00 [pubmed]
PHST- 2012/05/23 06:00 [medline]
AID - 10.1007/s10730-011-9161-x [doi]
PST - ppublish
SO  - HEC Forum. 2011 Dec;23(4):295-304. doi: 10.1007/s10730-011-9161-x.


PMID- 21822633
OWN - NLM
STAT- MEDLINE
DCOM- 20120206
LR  - 20211020
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 23
IP  - 3
DP  - 2011 Sep
TI  - Ethics in the discipline(s) of bioethics.
PG  - 171-92
LID - 10.1007/s10730-011-9163-8 [doi]
AB  - The development of a code of ethics for a profession can be an indicator of the
      coherence and stability of a discipline as a unique and singular entity. Since
      "bioethics", as a discipline, is not one profession but many, practiced by
      persons with not one but many varying responsibilities and training, it has been 
      argued that no code of ethics is possible for the discipline(s) of bioethics. I
      argue that a code of ethics is possible for bioethics by looking at the nature of
      the various disciplines and noting necessary overlap between them, and deriving
      the ethics from the nature of the discipline(s) themselves. I show how this can
      be done by arguing that strict rules about funding and conflict of interest are
      necessary for bioethicists.
FAU - Hanson, Stephen S
AU  - Hanson SS
AD  - Department of Philosophy, University of Louisville, KY 40292, USA.
      stephen.hanson@louisville.edu
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - *Codes of Ethics
MH  - *Conflict of Interest
MH  - Ethicists/*standards
MH  - Health Care Sector/ethics
MH  - Humans
MH  - Interprofessional Relations/*ethics
MH  - Remuneration
MH  - United States
EDAT- 2011/08/09 06:00
MHDA- 2012/02/07 06:00
CRDT- 2011/08/09 06:00
PHST- 2011/08/09 06:00 [entrez]
PHST- 2011/08/09 06:00 [pubmed]
PHST- 2012/02/07 06:00 [medline]
AID - 10.1007/s10730-011-9163-8 [doi]
PST - ppublish
SO  - HEC Forum. 2011 Sep;23(3):171-92. doi: 10.1007/s10730-011-9163-8.


PMID- 21822559
OWN - NLM
STAT- MEDLINE
DCOM- 20120524
LR  - 20120622
IS  - 1534-4681 (Electronic)
IS  - 1068-9265 (Linking)
VI  - 19
IP  - 2
DP  - 2012 Feb
TI  - Laparoscopic right hepatectomy with intrahepatic transection of the right bile
      duct.
PG  - 467-8
LID - 10.1245/s10434-011-1927-5 [doi]
AB  - BACKGROUND: Although our earlier videos demonstrated extrahepatic control of the 
      hepatic arterial, portal venous, and biliary system, we have begun transecting
      the biliary system intraparenchymally for lesions distant from hilar plate and
      the confluence of the right and left hepatic ducts.1 (-) 3 METHODS: The patient
      was a 50-year old gentleman with synchronous colorectal hepatic metastasis, who
      underwent 6 cycles of neoadjuvant chemotherapy with a Folfox-based regimen
      followed by laparoscopic right hepatectomy plus wedge resection of segment 4 and 
      microwave ablation for a lesion in segment 2. This was followed 1 month later by 
      laparoscopic proctocolectomy. Of note, the patient was also treated with Avastin 
      for 1 month, which was stopped 2 months prior to his liver surgery.
      Pneumoperitoneum was obtained with the Veress needed; alternatively, the open
      technique may need to be used in patients who have undergone previous surgery. A 
      12-mm blunt tip balloon trocar was placed approximately 1 hand-breadth below the 
      right costal margin. Two 12-mm working trocars were placed to the left and right 
      of this optic trocar, and trocars were then placed in the left sub xiphoid region
      and in the right flank for the assistants. The right hepatic artery was triply
      clipped proximally and twice distally prior to being sharply transected. The
      right hepatic portal vein was then transected using a laparoscopic vascular GIA
      stapler device (TriStapler, Covidien, Norwalk, CT). The anterior surface of the
      liver was examined, and there was a clear line of demarcation along Cantlie's
      line. Using the ultrasonic shears (Harmonic Scalpel, Ethicon, Cincinnati, OH),
      the liver parenchyma was then transected. In the area of the right hepatic duct, 
      the liver parenchyma was transected with a single firing of the laparoscopic GIA 
      vascular stapler device. The right hepatic vein was then identified and similarly
      transected with a single firing of the laparoscopic vascular GIA stapler device. 
      Hemostasis along the hepatic parenchyma was reinforced with the laparoscopic
      bipolar device. The two trocars on the right of the patient are connected into 1 
      incision, and a gel port is placed to facilitate removal of the specimen;
      alternatively, an old incision can be used. For patients who will need a
      laparoscopic or open colectomy, a lower midline incision is made. RESULTS: From
      Jan 2009 to Oct 2010, 13 patients underwent right hepatectomy. The average age
      was 63.5 years (range, 46-87 years). The indication for surgery were all for
      cancer including 11 colorectal metastasis, 1 anal cancer metastasis, and 1
      cholangiocarcinoma. In these 13 patients, 1 patient (7.7%) required conversion to
      an open approach because of bleeding, 1 additional patient required laparoscopic 
      hand assistance, and the remaining patients were completed laparoscopically.
      There were no surgical mortalities at 30 or 90 days. Complications occurred in 2 
      (15%) patients, and included 1 patient who was converted to an open procedure
      because of hemorrhage and was complicated by a bile leak; the second patient with
      complication also developed a 1-bile leak, both of which responded to
      percutaneous treatments. The mean hospital stay was 7.7 days (range, 5-17 days). 
      The mean operative time was 401 min (range, 220-600 min). The mean estimated
      blood loss was 878 cm(3) (range, 100-3,000 cm(3)). All patients underwent an R0
      resection. DISCUSSION: Laparoscopic major hepatectomy is feasible. As in open
      hepatectomies, intrahepatic transection of the right bile duct may be safer
      because there is a decreased risk of injury to the left hepatic duct.4 (,) 5
      Larger series with longer-term follow-up are necessary.
FAU - Tsai, Tzu-Jung
AU  - Tsai TJ
AD  - Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA.
FAU - Chouillard, Elie K
AU  - Chouillard EK
FAU - Gumbs, Andrew A
AU  - Gumbs AA
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Video-Audio Media
DEP - 20110806
PL  - United States
TA  - Ann Surg Oncol
JT  - Annals of surgical oncology
JID - 9420840
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
MH  - Bile Ducts/*surgery
MH  - Colorectal Neoplasms/drug therapy/pathology
MH  - Hepatectomy/*methods
MH  - Humans
MH  - Laparoscopy/*methods
MH  - Liver Neoplasms/drug therapy/secondary/*surgery
MH  - Male
MH  - Middle Aged
MH  - Treatment Outcome
EDAT- 2011/08/09 06:00
MHDA- 2012/06/23 06:00
CRDT- 2011/08/09 06:00
PHST- 2010/11/27 00:00 [received]
PHST- 2011/08/09 06:00 [entrez]
PHST- 2011/08/09 06:00 [pubmed]
PHST- 2012/06/23 06:00 [medline]
AID - 10.1245/s10434-011-1927-5 [doi]
PST - ppublish
SO  - Ann Surg Oncol. 2012 Feb;19(2):467-8. doi: 10.1245/s10434-011-1927-5. Epub 2011
      Aug 6.


PMID- 21822472
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 2042-0080 (Electronic)
IS  - 2042-0080 (Linking)
VI  - 2011
DP  - 2011
TI  - A review of social and relational aspects of deep brain stimulation in
      Parkinson's disease informed by healthcare provider experiences.
PG  - 871874
LID - 10.4061/2011/871874 [doi]
AB  - Background. Although the clinical effectiveness of deep brain stimulation (DBS)
      in Parkinson's disease is established, there has been less examination of its
      social aspects. Methods and Results. Building on qualitative comments provided by
      healthcare providers, we present four different social and relational issues
      (need for social support, changes in relationships (with self and partner) and
      challenges with regards to occupation and the social system). We review the
      literature from multiple disciplines on each issue. We comment on their ethical
      implications and conclude by establishing the future prospects for research with 
      the possible expansion of DBS for psychiatric indications. Conclusions. Our
      review demonstrates that there are varied social issues involved in DBS. These
      issues may have significant impacts on the perceived outcome of DBS by patients. 
      Moreover, the fact that the social impact of DBS is still not well understood in 
      emerging psychiatric indications presents an important area for future
      examination.
FAU - Bell, Emily
AU  - Bell E
AD  - Neuroethics Research Unit, Institut de recherches cliniques de Montreal (IRCM),
      Montreal, QC, Canada H2W lR7.
FAU - Maxwell, Bruce
AU  - Maxwell B
FAU - McAndrews, Mary Pat
AU  - McAndrews MP
FAU - Sadikot, Abbas F
AU  - Sadikot AF
FAU - Racine, Eric
AU  - Racine E
LA  - eng
PT  - Journal Article
DEP - 20110407
PL  - United States
TA  - Parkinsons Dis
JT  - Parkinson's disease
JID - 101539877
PMC - PMC3132670
EDAT- 2011/08/09 06:00
MHDA- 2011/08/09 06:01
CRDT- 2011/08/09 06:00
PHST- 2010/10/13 00:00 [received]
PHST- 2011/02/15 00:00 [accepted]
PHST- 2011/08/09 06:00 [entrez]
PHST- 2011/08/09 06:00 [pubmed]
PHST- 2011/08/09 06:01 [medline]
AID - 10.4061/2011/871874 [doi]
PST - ppublish
SO  - Parkinsons Dis. 2011;2011:871874. doi: 10.4061/2011/871874. Epub 2011 Apr 7.


PMID- 21822019
OWN - NLM
STAT- MEDLINE
DCOM- 20120111
LR  - 20110916
IS  - 1421-9824 (Electronic)
IS  - 1420-8008 (Linking)
VI  - 32
IP  - 1
DP  - 2011
TI  - Decision-making in frontotemporal dementia: clinical, theoretical and legal
      implications.
PG  - 11-7
LID - 10.1159/000329912 [doi]
AB  - BACKGROUND: The behavioral variant of frontotemporal dementia (bvFTD) is
      characterized by progressive changes in personality and social interaction, loss 
      of empathy, disinhibition and impulsivity, most of which generally precede the
      onset of cognitive deficits. In this study, we investigated decision-making
      cognition in a group of patients with an early bvFTD diagnosis whose standard
      neuropsychological performance was within normal range for all variables.
      METHODS: The Iowa Gambling Task was administered to this group of early bvFTD
      patients, to a group of early bvFTD patients who had shown impaired performance
      on the classical neuropsychological battery and to healthy controls. RESULTS:
      Decision-making was impaired in both bvFTD patient groups, whether they had shown
      impaired or normal performance in the classical neuropsychological evaluation.
      CONCLUSIONS: Patients with early bvFTD may perform normally on standard cognitive
      tests, and yet develop severe deficits in judgment and decision-making. In many
      current legal systems, early bvFTD patients showing preserved cognitive
      functioning who commit unlawful acts run the risk of not being able to plead
      insane or not guilty on the grounds of diminished responsibility beyond
      reasonable doubt. This represents a unique legal and ethical dilemma. Our
      findings have important implications for medicolegal decisions relating to
      capacity and culpability, and regarding the philosophical concept of 'free will'.
CI  - 2011 S. Karger AG, Basel.
FAU - Manes, Facundo
AU  - Manes F
AD  - Institute of Cognitive Neurology (INECO), Favaloro University, Buenos Aires,
      Argentina. fmanes @ ineco.org.ar
FAU - Torralva, Teresa
AU  - Torralva T
FAU - Ibanez, Agustin
AU  - Ibanez A
FAU - Roca, Maria
AU  - Roca M
FAU - Bekinschtein, Tristan
AU  - Bekinschtein T
FAU - Gleichgerrcht, Ezequiel
AU  - Gleichgerrcht E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110804
PL  - Switzerland
TA  - Dement Geriatr Cogn Disord
JT  - Dementia and geriatric cognitive disorders
JID - 9705200
SB  - IM
MH  - Aged
MH  - Cognition/physiology
MH  - Decision Making/*physiology
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Female
MH  - Frontotemporal Lobar Degeneration/*psychology
MH  - Gambling
MH  - Humans
MH  - *Insanity Defense
MH  - Judgment
MH  - Male
MH  - Memory/physiology
MH  - Mental Recall/physiology
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Psychomotor Performance/physiology
MH  - Verbal Behavior/physiology
EDAT- 2011/08/09 06:00
MHDA- 2012/01/12 06:00
CRDT- 2011/08/09 06:00
PHST- 2011/06/06 00:00 [accepted]
PHST- 2011/08/09 06:00 [entrez]
PHST- 2011/08/09 06:00 [pubmed]
PHST- 2012/01/12 06:00 [medline]
AID - 000329912 [pii]
AID - 10.1159/000329912 [doi]
PST - ppublish
SO  - Dement Geriatr Cogn Disord. 2011;32(1):11-7. doi: 10.1159/000329912. Epub 2011
      Aug 4.


PMID- 21822002
OWN - NLM
STAT- MEDLINE
DCOM- 20120810
LR  - 20111025
IS  - 1423-0305 (Electronic)
IS  - 1016-2291 (Linking)
VI  - 47
IP  - 2
DP  - 2011
TI  - CSF shunt complications in infants--an experience from Pakistan.
PG  - 93-8
LID - 10.1159/000329628 [doi]
AB  - AIMS AND OBJECTIVE: The main aim of the study was to find out the postoperative
      complications and long-term outcome of cerebrospinal fluid-shunted patients in an
      infantile age group with a poor socioeconomic background. MATERIAL AND METHODS: A
      prospective study of 100 cases of infantile hydrocephalus was conducted at
      Pakistan Institute of Medical Sciences, Islamabad, Pakistan. All selected
      patients suffering from congenital and post-meningitic hydrocephalus were
      operated on for ventriculoperitoneal shunt. However, cases of hydrocephalus
      secondary to myelomeningocele were not included. Patients were followed
      postoperatively for 2 years. Prior consent for surgery was taken from all parents
      and the study was approved by the hospital's academic and ethical council.
      RESULTS: The majority of patients were brought quite late to the medical
      facilities because of social taboos and socioeconomic conditions. Early signs and
      symptoms of hydrocephalus were either ignored or misunderstood. Shunt infection
      and shunt failure rates remained at 14 and 10%, respectively. 50% of shunt blocks
      occurred in the first postoperative year and another 50% within 2 years. The
      highest percentage (40-45%) of death occurred in patients suffering from
      congenital hydrocephalus, in the first postoperative year. CONCLUSIONS: This
      study concluded that the outcome and prognosis of shunted infantile hydrocephalus
      in developing countries is suboptimal due to different socioeconomic conditions. 
      However, under such circumstances, careful selection of patients, timely
      intervention and adherence to meticulous aseptic surgical techniques can alter
      the prognosis of cerebrospinal fluid-shunted infants.
CI  - Copyright (c) 2011 S. Karger AG, Basel.
FAU - Bakhsh, Ahmed
AU  - Bakhsh A
AD  - Saad Specialist Hospital, Al-Khobar, Kingdom of Saudi Arabia.
      ahmedbakhsh@gmail.com
LA  - eng
PT  - Journal Article
DEP - 20110804
PL  - Switzerland
TA  - Pediatr Neurosurg
JT  - Pediatric neurosurgery
JID - 9114967
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cerebrospinal Fluid Shunts/*adverse effects/economics
MH  - *Developing Countries/economics
MH  - Female
MH  - Humans
MH  - Hydrocephalus/economics/*ethnology/*surgery
MH  - Infant
MH  - Male
MH  - Pakistan/ethnology
MH  - Postoperative Complications/economics/*ethnology/etiology
MH  - Prospective Studies
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2011/08/09 06:00
MHDA- 2012/08/11 06:00
CRDT- 2011/08/09 06:00
PHST- 2011/01/10 00:00 [received]
PHST- 2011/05/23 00:00 [accepted]
PHST- 2011/08/09 06:00 [entrez]
PHST- 2011/08/09 06:00 [pubmed]
PHST- 2012/08/11 06:00 [medline]
AID - 000329628 [pii]
AID - 10.1159/000329628 [doi]
PST - ppublish
SO  - Pediatr Neurosurg. 2011;47(2):93-8. doi: 10.1159/000329628. Epub 2011 Aug 4.


PMID- 21821996
OWN - NLM
STAT- MEDLINE
DCOM- 20120325
LR  - 20181201
IS  - 1663-2826 (Electronic)
IS  - 1663-2818 (Linking)
VI  - 76
IP  - 5
DP  - 2011
TI  - Ethical principles: an essential part of the process in disorders of sex
      development care.
PG  - 367-8
LID - 10.1159/000328316 [doi]
FAU - Gillam, Lynn H
AU  - Gillam LH
AD  - Children's Bioethics Centre, Royal Children's Hospital, Melbourne, Vic.,
      Australia. l.gillam@unimelb.edu.au
FAU - Hewitt, Jacqueline K
AU  - Hewitt JK
FAU - Warne, Garry L
AU  - Warne GL
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20110804
PL  - Switzerland
TA  - Horm Res Paediatr
JT  - Hormone research in paediatrics
JID - 101525157
SB  - IM
CON - Horm Res Paediatr. 2010;74(6):419-20. PMID: 21160198
MH  - Decision Making/*ethics
MH  - Disorders of Sex Development/*surgery
MH  - *Ethics, Medical
MH  - Female
MH  - Humans
MH  - Male
MH  - Urogenital Surgical Procedures/*ethics
EDAT- 2011/08/09 06:00
MHDA- 2012/03/27 06:00
CRDT- 2011/08/09 06:00
PHST- 2011/03/21 00:00 [received]
PHST- 2011/04/04 00:00 [accepted]
PHST- 2011/08/09 06:00 [entrez]
PHST- 2011/08/09 06:00 [pubmed]
PHST- 2012/03/27 06:00 [medline]
AID - 000328316 [pii]
AID - 10.1159/000328316 [doi]
PST - ppublish
SO  - Horm Res Paediatr. 2011;76(5):367-8. doi: 10.1159/000328316. Epub 2011 Aug 4.


PMID- 21821628
OWN - NLM
STAT- MEDLINE
DCOM- 20120301
LR  - 20181201
IS  - 1471-8391 (Electronic)
IS  - 0007-1420 (Linking)
VI  - 99
DP  - 2011
TI  - Stem cell therapy for articular cartilage defects.
PG  - 227-40
LID - 10.1093/bmb/ldr032 [doi]
AB  - BACKGROUND: Stem cells are easily accessible and have great potential for healing
      articular cartilage defects. These features make stem cell therapy an appealing
      approach for treating severely impaired joint function. SOURCES OF DATA: Clinical
      and basic research articles and literature reviews. AREAS OF AGREEMENT: Stem
      cells possess the potential to build articular cartilage. Malalignment and
      instability corrections and proper rehabilitation are crucial prerequisites for
      surgical procedures involving stem cell therapy. Smoking reduces the result.
      AREAS OF CONTROVERSY: Ethical concerns remain unresolved. No standards are
      established for inducing stem cell potential, optimizing culturing media or
      harvesting. The risk of failure has not been determined. GROWING POINTS: Surgical
      scaffolds can improve results. Care givers should focus on re-educating patients.
      Improved funding is needed for developing the therapy. AREAS TIMELY FOR
      DEVELOPING RESEARCH: Define guidelines for stem cell therapy and demonstrate
      effectiveness.
FAU - Aroen, Asbjorn
AU  - Aroen A
AD  - Oslo Sports Trauma Research Center and Department of Orthopedic Surgery, Akershus
      University Hospital, Lorenskog, N-1478 Lorenskog, Norway.
      asbjorn.aroen@medisin.uio.no
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110805
PL  - England
TA  - Br Med Bull
JT  - British medical bulletin
JID - 0376542
SB  - IM
MH  - Animals
MH  - Cartilage Diseases/complications/pathology/physiopathology/*therapy
MH  - *Cartilage, Articular/pathology/physiology
MH  - Clinical Trials as Topic
MH  - *Guided Tissue Regeneration/instrumentation/methods
MH  - Humans
MH  - Joint Instability/etiology/rehabilitation
MH  - *Mesenchymal Stem Cell Transplantation/ethics/methods/trends
MH  - Mesenchymal Stem Cells/physiology
MH  - Regeneration/*physiology
MH  - Stem Cell Research
MH  - *Tissue Engineering/methods/trends
MH  - Tissue Scaffolds
MH  - Treatment Outcome
EDAT- 2011/08/09 06:00
MHDA- 2012/03/02 06:00
CRDT- 2011/08/09 06:00
PHST- 2011/08/09 06:00 [entrez]
PHST- 2011/08/09 06:00 [pubmed]
PHST- 2012/03/02 06:00 [medline]
AID - ldr032 [pii]
AID - 10.1093/bmb/ldr032 [doi]
PST - ppublish
SO  - Br Med Bull. 2011;99:227-40. doi: 10.1093/bmb/ldr032. Epub 2011 Aug 5.


PMID- 21821572
OWN - NLM
STAT- MEDLINE
DCOM- 20111221
LR  - 20220409
IS  - 1544-5208 (Electronic)
IS  - 0278-2715 (Linking)
VI  - 30
IP  - 8
DP  - 2011 Aug
TI  - The level of income appears to have no consistent bearing on pharmaceutical
      prices across countries.
PG  - 1545-52
LID - 10.1377/hlthaff.2010.0317 [doi]
AB  - A generally accepted view is that it is more efficient and ethical if global
      pharmaceutical prices vary according to countries' relative income. To understand
      manufacturers' pricing strategies, we compared average pharmaceutical prices in
      fourteen middle-income countries to those in three high-income countries and a
      low-income region in western Africa from 1999 through 2008. We found that some
      middle-income countries pay more for pharmaceuticals than high-income
      countries--for example, prices in several middle-income countries exceeded those 
      in the United Kingdom for some years of the study period. Other middle-income
      countries paid less than low-income countries--for example, average prices in
      India were consistently below prices in western Africa. These variations suggest 
      that we need new policies on pharmaceutical pricing to improve access to
      pharmaceuticals around the world.
FAU - Morel, Chantal M
AU  - Morel CM
AD  - London School of Economics, United Kingdom. C.M.Morel@lse.ac.uk
FAU - McGuire, Alistair
AU  - McGuire A
FAU - Mossialos, Elias
AU  - Mossialos E
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Health Aff (Millwood)
JT  - Health affairs (Project Hope)
JID - 8303128
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Developing Countries/*economics
MH  - Drug Costs/*trends
MH  - Income
MH  - Organizational Policy
MH  - Pharmaceutical Preparations/supply & distribution
EDAT- 2011/08/09 06:00
MHDA- 2011/12/22 06:00
CRDT- 2011/08/09 06:00
PHST- 2011/08/09 06:00 [entrez]
PHST- 2011/08/09 06:00 [pubmed]
PHST- 2011/12/22 06:00 [medline]
AID - 30/8/1545 [pii]
AID - 10.1377/hlthaff.2010.0317 [doi]
PST - ppublish
SO  - Health Aff (Millwood). 2011 Aug;30(8):1545-52. doi: 10.1377/hlthaff.2010.0317.


PMID- 21821324
OWN - NLM
STAT- MEDLINE
DCOM- 20120628
LR  - 20120228
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 74
IP  - 6
DP  - 2012 Mar
TI  - How is health-related "deservingness" reckoned? Perspectives from unauthorized
      im/migrants in Tel Aviv.
PG  - 812-21
LID - 10.1016/j.socscimed.2011.06.033 [doi]
AB  - Do unauthorized im/migrants have a right to health? Do they deserve health care, 
      or health protection, or access to the social determinants of good health? Are
      they party to prevailing social contracts, or does their exclusion from
      mainstream systems of health promotion, prevention, and care "make sense"?
      Questions like these, which generate considerable attention in multiple spheres
      of scholarship, policy, and public debate, revolve around an issue that merits
      substantially greater consideration among social scientists of health:
      health-related "deservingness." In addition to putting the issue of
      health-related deservingness squarely on the map as an object of analysis, this
      article further argues that we cannot focus solely on those with power,
      influence, and public voice. Rather, we also must investigate how deservingness
      is reckoned in relation to--and, furthermore, from the perspectives of--
      unauthorized im/migrants and members of other groups commonly constructed in
      public and policy discourse as undeserving. Additionally, we must consider the
      complicated relationship between universalizing juridical arguments about formal 
      entitlement to health rights, on one hand, and situationally specific, vernacular
      moral arguments about deservingness, on the other. The paper analyzes findings
      from a 29-month mixed-methods study conducted in Tel Aviv, Israel, that
      approached unauthorized im/migrants as subjects, rather than simply objects, of
      ethical deliberation. Participants' conceptions of health-related deservingness
      are investigated using two sources of data: (1) quantitative findings from a
      self-administered, closed-ended survey conducted with 170 im/migrant patients at 
      an NGO-run Open Clinic (2002-2003), and (2) qualitative findings from the larger 
      ethnographic study of which the survey was part (2000-2010). The study findings
      both (1) contradict commonly circulating assumptions that unauthorized
      im/migrants are "freeloaders," and (2) highlight the need for rigorous
      investigation of how unauthorized im/migrants, among other marginalized and
      vulnerable groups, conceptualize their own relative deservingness of
      health-related concern and investment.
CI  - Copyright A(c) 2011 Elsevier Ltd. All rights reserved.
FAU - Willen, Sarah S
AU  - Willen SS
AD  - University of Connecticut, Department of Anthropology, 354 Mansfield Road, Unit
      2176, Beach Hall, Storrs, CT 06269-2176, USA. sarah.willen@gmail.com
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110720
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Anthropology, Cultural
MH  - Female
MH  - Health Services Accessibility/statistics & numerical data
MH  - *Health Status Disparities
MH  - Healthcare Disparities/*statistics & numerical data
MH  - *Human Rights
MH  - Humans
MH  - Israel
MH  - Male
MH  - Medical Assistance
MH  - Middle Aged
MH  - Morals
MH  - Politics
MH  - Public Opinion
MH  - Sex Factors
MH  - Socioeconomic Factors
MH  - Sociology, Medical
MH  - Time Factors
MH  - Transients and Migrants/*psychology
MH  - Vulnerable Populations/psychology
MH  - Young Adult
EDAT- 2011/08/09 06:00
MHDA- 2012/06/29 06:00
CRDT- 2011/08/09 06:00
PHST- 2010/12/17 00:00 [received]
PHST- 2011/06/10 00:00 [revised]
PHST- 2011/06/16 00:00 [accepted]
PHST- 2011/08/09 06:00 [entrez]
PHST- 2011/08/09 06:00 [pubmed]
PHST- 2012/06/29 06:00 [medline]
AID - S0277-9536(11)00398-4 [pii]
AID - 10.1016/j.socscimed.2011.06.033 [doi]
PST - ppublish
SO  - Soc Sci Med. 2012 Mar;74(6):812-21. doi: 10.1016/j.socscimed.2011.06.033. Epub
      2011 Jul 20.


PMID- 21821223
OWN - NLM
STAT- MEDLINE
DCOM- 20111205
LR  - 20160803
IS  - 1878-7452 (Electronic)
IS  - 1878-7452 (Linking)
VI  - 68
IP  - 5
DP  - 2011 Sep-Oct
TI  - Video gaming enhances psychomotor skills but not visuospatial and perceptual
      abilities in surgical trainees.
PG  - 414-20
LID - 10.1016/j.jsurg.2011.03.009 [doi]
AB  - INTRODUCTION: There is considerable interest in the identification and assessment
      of underlying aptitudes or innate abilities that could potentially predict
      excellence in the technical aspects of operating. However, before the assessment 
      of innate abilities is introduced for high-stakes assessment (such as competitive
      selection into surgical training programs), it is essential to determine that
      these abilities are stable and unchanging and are not influenced by other
      factors, such as the use of video games. The aim of this study was to investigate
      whether experience playing video games will predict psychomotor performance on a 
      laparoscopic simulator or scores on tests of visuospatial and perceptual
      abilities, and to examine the correlation, if any, between these innate
      abilities. METHODS: Institutional ethical approval was obtained. Thirty-eight
      undergraduate medical students with no previous surgical experience were
      recruited. All participants completed a self-reported questionnaire that asked
      them to detail their video game experience. They then underwent assessment of
      their psychomotor, visuospatial, and perceptual abilities using previously
      validated tests. The results were analyzed using independent samples t tests to
      compare means and linear regression curves for subsequent analysis. RESULTS:
      Students who played video games for at least 7 hours per week demonstrated
      significantly better psychomotor skills than students who did not play video
      games regularly. However, there was no difference on measures of visuospatial and
      perceptual abilities. There was no correlation between psychomotor tests and
      visuospatial or perceptual tests. CONCLUSIONS: Regular video gaming correlates
      positively with psychomotor ability, but it does not seem to influence
      visuospatial or perceptual ability. This study suggests that video game
      experience might be beneficial to a future career in surgery. It also suggests
      that relevant surgical skills may be gained usefully outside the operating room
      in activities that are not related to surgery.
CI  - Copyright (c) 2011 Association of Program Directors in Surgery. Published by
      Elsevier Inc. All rights reserved.
FAU - Kennedy, A M
AU  - Kennedy AM
AD  - Royal College of Surgeons in Ireland, Dublin, Ireland. annkennedy@rcsi.ie
FAU - Boyle, E M
AU  - Boyle EM
FAU - Traynor, O
AU  - Traynor O
FAU - Walsh, T
AU  - Walsh T
FAU - Hill, A D K
AU  - Hill AD
LA  - eng
PT  - Journal Article
DEP - 20110526
PL  - United States
TA  - J Surg Educ
JT  - Journal of surgical education
JID - 101303204
SB  - IM
MH  - Adult
MH  - Computer Simulation
MH  - Forecasting
MH  - General Surgery/*economics
MH  - Humans
MH  - Laparoscopy/*methods
MH  - *Motor Skills
MH  - Space Perception
MH  - Students, Medical
MH  - *Video Games
MH  - Visual Perception
MH  - Young Adult
EDAT- 2011/08/09 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/08/09 06:00
PHST- 2011/01/02 00:00 [received]
PHST- 2011/02/28 00:00 [revised]
PHST- 2011/03/23 00:00 [accepted]
PHST- 2011/08/09 06:00 [entrez]
PHST- 2011/08/09 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S1931-7204(11)00107-3 [pii]
AID - 10.1016/j.jsurg.2011.03.009 [doi]
PST - ppublish
SO  - J Surg Educ. 2011 Sep-Oct;68(5):414-20. doi: 10.1016/j.jsurg.2011.03.009. Epub
      2011 May 26.


PMID- 21820520
OWN - NLM
STAT- MEDLINE
DCOM- 20120801
LR  - 20220330
IS  - 1873-488X (Electronic)
IS  - 1056-8719 (Linking)
VI  - 64
IP  - 2
DP  - 2011 Sep-Oct
TI  - In vivo laboratory practicals in research-led teaching: an example using glucose 
      tolerance tests in lean and obese mice.
PG  - 168-72
LID - 10.1016/j.vascn.2011.07.002 [doi]
AB  - The use of animal models is an essential part of medical research and drug
      development. The essential skills required to be able to do such research
      includes experimental design, statistical analysis and the actual handling and
      treating of the animals (in vivo skills). The number of students in the U.K.
      receiving training in handling and experimenting on animals has declined rapidly 
      in the last few decades which has led to initiatives to increase numbers of
      students with these skills to meet demand. Within the Department of Pharmacology 
      and Therapeutics at King's College London, we run a course for 2nd year
      undergraduates entitled "Animal models of disease and injury". This course not
      only covers the theoretical and ethical aspects of using animals in research, but
      also contains practical laboratory classes in which students get hands-on
      experience using animals. One of the laboratory classes we run is a glucose
      tolerance test in obese and lean mice. This is an example of research-led
      teaching which aims to develop research skills through engaging students in
      research like activities. In this paper, we outline the methodology of the
      glucose tolerance practical and highlight some of the skills we and the students 
      think they gain by research-led teaching such as this.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - King, Aileen J F
AU  - King AJ
AD  - Diabetes Research Group, King's College London, UK. aileen.king@kcl.ac.uk
FAU - Bowe, James E
AU  - Bowe JE
FAU - Sprake, Juliet A
AU  - Sprake JA
FAU - Kinchin, Ian M
AU  - Kinchin IM
LA  - eng
PT  - Journal Article
DEP - 20110727
PL  - United States
TA  - J Pharmacol Toxicol Methods
JT  - Journal of pharmacological and toxicological methods
JID - 9206091
SB  - IM
MH  - *Animal Experimentation/ethics
MH  - Animals
MH  - Biomedical Research/*education
MH  - *Disease Models, Animal
MH  - Glucose Tolerance Test/*methods
MH  - Humans
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Obesity/physiopathology
MH  - Professional Competence
MH  - Research Design
MH  - Students
MH  - Teaching/methods
MH  - United Kingdom
EDAT- 2011/08/09 06:00
MHDA- 2012/08/02 06:00
CRDT- 2011/08/09 06:00
PHST- 2011/01/12 00:00 [received]
PHST- 2011/07/05 00:00 [revised]
PHST- 2011/07/19 00:00 [accepted]
PHST- 2011/08/09 06:00 [entrez]
PHST- 2011/08/09 06:00 [pubmed]
PHST- 2012/08/02 06:00 [medline]
AID - S1056-8719(11)00268-1 [pii]
AID - 10.1016/j.vascn.2011.07.002 [doi]
PST - ppublish
SO  - J Pharmacol Toxicol Methods. 2011 Sep-Oct;64(2):168-72. doi:
      10.1016/j.vascn.2011.07.002. Epub 2011 Jul 27.


PMID- 21820346
OWN - NLM
STAT- MEDLINE
DCOM- 20120118
LR  - 20110829
IS  - 1769-6682 (Electronic)
IS  - 1297-9589 (Linking)
VI  - 39
IP  - 9
DP  - 2011 Sep
TI  - [Female fertility preservation: feasibility of emergency IVF for embryo
      freezing].
PG  - 497-500
LID - 10.1016/j.gyobfe.2011.07.010 [doi]
AB  - With the improvement of the anticancerous treatments, the preservation of the
      feminine fertility before gonadotoxic treatment tends at present to stand out as 
      a legal obligation, with a duty of information to patients. When emergency IVF
      can be performed, the cryopreservation of embryos is the best mastered method
      which offers most chances to patients to obtain a pregnancy after cancer
      remission thanks to the transfer of frozen embryos. This article proposes an
      overview about the indications, the feasibility and the ethical and practical
      limitations of IVF emergency for embryo freezing before gonadotoxic anticancerous
      treatment.
CI  - Copyright (c) 2011 Elsevier Masson SAS. All rights reserved.
FAU - Courbiere, B
AU  - Courbiere B
AD  - Pole de gynecologie-obstetrique et de medecine de la reproduction, AP-HM La
      Conception, 147 boulevard Baille, Marseille, France. blandine.courbiere@ap-hm.fr
FAU - Saias-Magnan, J
AU  - Saias-Magnan J
FAU - Metzler-Guillemain, C
AU  - Metzler-Guillemain C
FAU - Perrin, J
AU  - Perrin J
FAU - Noizet, A
AU  - Noizet A
FAU - Gamerre, M
AU  - Gamerre M
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Faisabilite de la congelation embryonnaire dans la preservation de la fertilite
      feminine.
DEP - 20110804
PL  - France
TA  - Gynecol Obstet Fertil
JT  - Gynecologie, obstetrique & fertilite
JID - 100936305
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Antineoplastic Agents/adverse effects
MH  - *Cryopreservation
MH  - Embryo Transfer
MH  - *Embryo, Mammalian
MH  - Feasibility Studies
MH  - Female
MH  - Fertility Preservation/ethics/*methods
MH  - *Fertilization in Vitro/ethics
MH  - Humans
MH  - Infertility, Female/etiology
MH  - Pregnancy
MH  - Radiotherapy/adverse effects
EDAT- 2011/08/09 06:00
MHDA- 2012/01/19 06:00
CRDT- 2011/08/09 06:00
PHST- 2011/06/02 00:00 [received]
PHST- 2011/06/03 00:00 [accepted]
PHST- 2011/08/09 06:00 [entrez]
PHST- 2011/08/09 06:00 [pubmed]
PHST- 2012/01/19 06:00 [medline]
AID - S1297-9589(11)00234-7 [pii]
AID - 10.1016/j.gyobfe.2011.07.010 [doi]
PST - ppublish
SO  - Gynecol Obstet Fertil. 2011 Sep;39(9):497-500. doi: 10.1016/j.gyobfe.2011.07.010.
      Epub 2011 Aug 4.


PMID- 21819377
OWN - NLM
STAT- MEDLINE
DCOM- 20111201
LR  - 20120217
IS  - 2146-8427 (Electronic)
IS  - 1304-0855 (Linking)
VI  - 9
IP  - 4
DP  - 2011 Aug
TI  - Ethical dilemma of recovering organs before donor death.
PG  - 284-5
AB  - Organ transplant has had a momentous effect in improving global health over the
      years. However, there exists a sizeable discrepancy between the supply and demand
      of organs, especially in developing countries, where lack of expertise, financial
      constraints, and inadequate transplant facilities have been obstacles. According 
      to current practice, donors must be dead before unpaired vital organs can be
      recovered. Equal health warrants needs-based health care for everyone. Recovering
      viable organs from donors while they are alive, but with death inevitable, may be
      significant to persons on waiting lists. Future policies in organ transplantation
      must be made after thorough consideration of all aspects of donation and dealing 
      with the inequalities of health care. These pose a challenge for medicolegal and 
      ethical organizations.
FAU - Khalid, Umair
AU  - Khalid U
FAU - Khalil, Sarwat
AU  - Khalil S
LA  - eng
PT  - Letter
PL  - Turkey
TA  - Exp Clin Transplant
JT  - Experimental and clinical transplantation : official journal of the Middle East
      Society for Organ Transplantation
JID - 101207333
SB  - IM
MH  - Health Policy
MH  - Health Services Needs and Demand
MH  - Humans
MH  - Organ Transplantation/*ethics/legislation & jurisprudence
MH  - *Patient Rights
MH  - Tissue Donors/*ethics/legislation & jurisprudence/supply & distribution
MH  - Tissue and Organ Harvesting/*ethics/legislation & jurisprudence
MH  - Tissue and Organ Procurement/*ethics/legislation & jurisprudence
MH  - Waiting Lists
EDAT- 2011/08/09 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/08/09 06:00
PHST- 2011/08/09 06:00 [entrez]
PHST- 2011/08/09 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PST - ppublish
SO  - Exp Clin Transplant. 2011 Aug;9(4):284-5.


PMID- 21818814
OWN - NLM
STAT- MEDLINE
DCOM- 20111014
LR  - 20131121
IS  - 1097-0231 (Electronic)
IS  - 0951-4198 (Linking)
VI  - 25
IP  - 17
DP  - 2011 Sep 15
TI  - The use of multi-element stable isotope analysis to monitor the origin of
      chondroitin sulfates.
PG  - 2533-7
LID - 10.1002/rcm.5159 [doi]
AB  - Continuous-flow isotope ratio mass spectrometry (CF-IRMS) of deuterium, carbon,
      nitrogen, oxygen and sulfur has been used to analyse samples of pure chondroitin 
      sulfates from known animal sources (shark, squid, salmon, pig and bovine). There 
      is a need to control the origin of this dietary supplement, which is extracted
      from several types of animals: for traditional, ethical, or economic reasons, a
      given source of natural products of animal origin can be preferred to another,
      and can therefore have a different price. Twenty-three samples collected in
      Europe and Asia were analysed by IRMS. The results, especially the isotopic
      deviations of sulphur, oxygen and deuterium, show a significant discrimination
      between marine and terrestrial origins of this compound which will provide a
      convenient and efficient way to control the declared sources in the market. The
      differences observed between origins are further discussed.
CI  - Copyright (c) 2011 John Wiley & Sons, Ltd.
FAU - Thomas, Freddy
AU  - Thomas F
AD  - Eurofins Analytics France, Nantes, France. FreddyThomas@eurofins.com
FAU - Jamin, Eric
AU  - Jamin E
FAU - Shimoo, Katsuya
AU  - Shimoo K
FAU - Nagao, Junji
AU  - Nagao J
FAU - Osaki, Yukihiko
AU  - Osaki Y
FAU - Granier, Colin
AU  - Granier C
LA  - eng
PT  - Journal Article
PL  - England
TA  - Rapid Commun Mass Spectrom
JT  - Rapid communications in mass spectrometry : RCM
JID - 8802365
RN  - 0 (Oxygen Isotopes)
RN  - 0 (Sulfur Isotopes)
RN  - 9007-28-7 (Chondroitin Sulfates)
RN  - AR09D82C7G (Deuterium)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Cattle
MH  - Chondroitin Sulfates/chemistry/*metabolism
MH  - Decapodiformes
MH  - Deuterium/analysis
MH  - Dietary Supplements/*analysis
MH  - Mass Spectrometry
MH  - Oxygen Isotopes/*analysis
MH  - Principal Component Analysis
MH  - Salmon
MH  - Sharks
MH  - Sulfur Isotopes/*analysis
MH  - Swine
EDAT- 2011/08/06 06:00
MHDA- 2011/10/15 06:00
CRDT- 2011/08/06 06:00
PHST- 2011/08/06 06:00 [entrez]
PHST- 2011/08/06 06:00 [pubmed]
PHST- 2011/10/15 06:00 [medline]
AID - 10.1002/rcm.5159 [doi]
PST - ppublish
SO  - Rapid Commun Mass Spectrom. 2011 Sep 15;25(17):2533-7. doi: 10.1002/rcm.5159.


PMID- 21818624
OWN - NLM
STAT- MEDLINE
DCOM- 20131213
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 2
DP  - 2013 Jun
TI  - Are the votes of ethics committees in Germany for the protection of clinical
      study trial subjects "sovereign acts?".
PG  - 341-54
LID - 10.1007/s11948-011-9299-6 [doi]
AB  - A sudden paradigm shift has resulted in governmental measures that greatly impact
      the scope in which the ethics committees in Germany can perform their task of
      providing expert opinions for clinical research. The so-called "revaluation" of
      the Medical Device Law Deutsches Medizinproduktegesetz-MPG) is, in our opinion,
      not based on sound political and professional judgment. In accordance with the
      changed regulations, ethics committees are now seen as being sub-organs of the
      state medical associations or the medical faculties and are therefore official
      authorities. It follows that the votes of ethics committees are then "sovereign
      acts" or authoritative measures! However, equality and justice speak against this
      misleading conclusion and its resulting consequence that an ethics committee's
      vote is a sovereign act. This has, in turn, resulted in the public ethics
      committees obtaining their long-sought goal of having a state-sanctioned
      monopoly. The private ethics committees are not recognized as being authoritative
      bodies, nor are they to be seen as such in the future (i.e. such a status has
      been denied the Freiburg Ethics Commission International (FEKI) in
      Baden-Wurttemberg). This political mistake must be corrected, otherwise,
      conducting clinical research will become increasingly difficult.
FAU - Graf, Hans-Peter
AU  - Graf HP
AD  - hp.graf@feki.com
LA  - eng
PT  - Journal Article
DEP - 20110805
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Biomedical Research/*ethics/legislation & jurisprudence
MH  - Equipment and Supplies
MH  - Ethics Committees, Research/*ethics/legislation & jurisprudence
MH  - Ethics, Research
MH  - *Federal Government
MH  - Germany
MH  - *Government Regulation
MH  - Humans
MH  - Politics
MH  - Private Sector
MH  - Public Policy
MH  - Public Sector
EDAT- 2011/08/06 06:00
MHDA- 2013/12/18 06:00
CRDT- 2011/08/06 06:00
PHST- 2011/01/29 00:00 [received]
PHST- 2011/07/15 00:00 [accepted]
PHST- 2011/08/06 06:00 [entrez]
PHST- 2011/08/06 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
AID - 10.1007/s11948-011-9299-6 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Jun;19(2):341-54. doi: 10.1007/s11948-011-9299-6. Epub 2011 
      Aug 5.


PMID- 21818237
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120827
LR  - 20211020
IS  - 1860-3572 (Electronic)
IS  - 1860-3572 (Linking)
VI  - 28
IP  - 2
DP  - 2011
TI  - Evidence-based Nursing Education - a Systematic Review of Empirical Research.
PG  - Doc27
LID - 10.3205/zma000739 [doi]
AB  - The project "Evidence-based Nursing Education - Preparatory Stage", funded by the
      Landesstiftung Baden-Wurttemberg within the programme Impulsfinanzierung
      Forschung (Funding to Stimulate Research), aims to collect information on current
      research concerned with nursing education and to process existing data. The
      results of empirical research which has already been carried out were
      systematically evaluated with aim of identifying further topics, fields and
      matters of interest for empirical research in nursing education. In the course of
      the project, the available empirical studies on nursing education were
      scientifically analysed and systematised. The over-arching aim of the
      evidence-based training approach - which extends beyond the aims of this project 
      - is the conception, organisation and evaluation of vocational training and
      educational processes in the caring professions on the basis of empirical data.
      The following contribution first provides a systematic, theoretical link to the
      over-arching reference framework, as the evidence-based approach is adapted from 
      thematically related specialist fields. The research design of the project is
      oriented towards criteria introduced from a selection of studies and carries out 
      a two-stage systematic review of the selected studies. As a result, the current
      status of research in nursing education, as well as its organisation and
      structure, and questions relating to specialist training and comparative
      education are introduced and discussed. Finally, the empirical research on
      nursing training is critically appraised as a complementary element in
      educational theory/psychology of learning and in the ethical tradition of
      research.This contribution aims, on the one hand, to derive and describe the
      methods used, and to introduce the steps followed in gathering and evaluating the
      data. On the other hand, it is intended to give a systematic overview of
      empirical research work in nursing education. In order to preserve a holistic
      view of the research field and methods, detailed individual findings are not
      included.
FAU - Reiber, Karin
AU  - Reiber K
AD  - Hochschule Esslingen, Fakultat Soziale Arbeit, Gesundheit und Pflege, Esslingen, 
      Deutschland.
LA  - eng
PT  - Journal Article
DEP - 20110516
PL  - Germany
TA  - GMS Z Med Ausbild
JT  - GMS Zeitschrift fur medizinische Ausbildung
JID - 101276035
PMC - PMC3149467
OTO - NOTNLM
OT  - Evidence based Training
OT  - Nursing Education
OT  - Vocational Training
OT  - empirical research
EDAT- 2011/08/06 06:00
MHDA- 2011/08/06 06:01
CRDT- 2011/08/06 06:00
PHST- 2010/09/24 00:00 [received]
PHST- 2010/12/21 00:00 [revised]
PHST- 2010/12/22 00:00 [accepted]
PHST- 2011/08/06 06:00 [entrez]
PHST- 2011/08/06 06:00 [pubmed]
PHST- 2011/08/06 06:01 [medline]
AID - 10.3205/zma000739 [doi]
AID - zma000739 [pii]
PST - ppublish
SO  - GMS Z Med Ausbild. 2011;28(2):Doc27. doi: 10.3205/zma000739. Epub 2011 May 16.


PMID- 21817885
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20211020
IS  - 1538-2990 (Electronic)
IS  - 0002-9629 (Linking)
VI  - 342
IP  - 4
DP  - 2011 Oct
TI  - Uncertainty and equipoise: at interplay between epistemology, decision making and
      ethics.
PG  - 282-9
LID - 10.1097/MAJ.0b013e318227e0b8 [doi]
AB  - In recent years, various authors have proposed that the concept of equipoise be
      abandoned because it conflates the practice of clinical care with clinical
      research. At the same time, the equipoise opponents acknowledge the necessity of 
      clinical research if there are unresolved uncertainties about the effects of
      proposed healthcare interventions. As equipoise represents just 1 measure of
      uncertainty, proposals to abandon equipoise while maintaining a requirement for
      addressing uncertainties are contradictory and ultimately not valid. As
      acknowledgment and articulation of uncertainties represent key scientific and
      moral requirements for human experimentation, the concept of equipoise remains
      the most useful framework to link the theory of human experimentation with the
      theory of rational choice. In this article, I show how uncertainty (equipoise) is
      at the intersection between epistemology, decision making and ethics of clinical 
      research. In particular, I show how our formulation of responses to uncertainties
      of hoped-for benefits and unknown harms of testing is a function of the way
      humans cognitively process information. This approach is based on the view that
      considerations of ethics and rationality cannot be separated. I analyze the
      response to uncertainties as it relates to the dual-processing theory, which
      postulates that rational approach to (clinical research) decision making depends 
      both on analytical, deliberative processes embodied in scientific method (system 
      II), and good human intuition (system I). Ultimately, our choices can only become
      wiser if we understand a close and intertwined relationship between irreducible
      uncertainty, inevitable errors and unavoidable injustice.
FAU - Djulbegovic, Benjamin
AU  - Djulbegovic B
AD  - Center and Division for Evidence-based Medicine and Health Outcome Research,
      Clinical Translational Science Institute, University of South Florida, Tampa,
      Florida, USA. bdjulbeg@health.usf.edu
LA  - eng
GR  - 1 R01 NS052956-01/NS/NINDS NIH HHS/United States
GR  - R01 NS044417-02/NS/NINDS NIH HHS/United States
GR  - R01 NS052956-01/NS/NINDS NIH HHS/United States
GR  - R01 CA140408/CA/NCI NIH HHS/United States
GR  - R01 NS052956-03/NS/NINDS NIH HHS/United States
GR  - R01 CA140408-01/CA/NCI NIH HHS/United States
GR  - R01 NS052956-02/NS/NINDS NIH HHS/United States
GR  - R01 CA140408-02/CA/NCI NIH HHS/United States
GR  - R01 NS052956/NS/NINDS NIH HHS/United States
GR  - 1R01CA133594-01/CA/NCI NIH HHS/United States
GR  - R01 NS044417-01/NS/NINDS NIH HHS/United States
GR  - 1R01NS044417-01/NS/NINDS NIH HHS/United States
GR  - R01 CA133594/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Am J Med Sci
JT  - The American journal of the medical sciences
JID - 0370506
SB  - IM
MH  - Bioethical Issues
MH  - Clinical Trials as Topic/ethics
MH  - Decision Making/ethics
MH  - Humans
MH  - Knowledge
MH  - Risk
MH  - *Therapeutic Equipoise
MH  - Uncertainty
PMC - PMC3183244
MID - NIHMS310374
EDAT- 2011/08/06 06:00
MHDA- 2011/11/09 06:00
CRDT- 2011/08/06 06:00
PHST- 2011/08/06 06:00 [entrez]
PHST- 2011/08/06 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - 10.1097/MAJ.0b013e318227e0b8 [doi]
AID - S0002-9629(15)31156-3 [pii]
PST - ppublish
SO  - Am J Med Sci. 2011 Oct;342(4):282-9. doi: 10.1097/MAJ.0b013e318227e0b8.


PMID- 21817874
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20211203
IS  - 1538-2990 (Electronic)
IS  - 0002-9629 (Linking)
VI  - 342
IP  - 4
DP  - 2011 Oct
TI  - The use of nonhuman animals in biomedical research.
PG  - 305-13
LID - 10.1097/MAJ.0b013e31822a6c35 [doi]
AB  - Opposition to the use of animals in biomedical research rests on diverse
      scientific and ethical arguments. Here I offer a response to key objections and
      argue that the responsible use of animals in biomedical research with the goal of
      advancing medical knowledge, science and human health, is scientifically and
      morally justified. My views are unlikely to be shared uniformly across the
      scientific community. Thus, I hope this personal perspective persuades other
      scientists, public health officials, scientific organizations and our academic
      leadership to join the debate and invites opponents of animal research to create 
      an atmosphere where civil discourse can take place, free of threats and
      intimidation. The public deserves an open and honest debate on this important
      topic.
FAU - Ringach, Dario L
AU  - Ringach DL
AD  - Department of Neurobiology, David Geffen School of Medicine, University of
      California, Los Angeles, Los Angeles, CA 90095, USA. dario@ucla.edu
LA  - eng
GR  - R01 EY018322/EY/NEI NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Am J Med Sci
JT  - The American journal of the medical sciences
JID - 0370506
SB  - IM
CIN - Am J Med Sci. 2011 Oct;342(4):345. PMID: 21952175
MH  - Animal Experimentation/*ethics
MH  - Animal Rights
MH  - Animal Use Alternatives/ethics
MH  - Animal Welfare/ethics
MH  - Animals
MH  - Bioethical Issues
MH  - Humans
MH  - Models, Animal
MH  - Translational Research, Biomedical/ethics
EDAT- 2011/08/06 06:00
MHDA- 2011/11/09 06:00
CRDT- 2011/08/06 06:00
PHST- 2011/08/06 06:00 [entrez]
PHST- 2011/08/06 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - 10.1097/MAJ.0b013e31822a6c35 [doi]
AID - S0002-9629(15)31160-5 [pii]
PST - ppublish
SO  - Am J Med Sci. 2011 Oct;342(4):305-13. doi: 10.1097/MAJ.0b013e31822a6c35.


PMID- 21817873
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20220317
IS  - 1538-2990 (Electronic)
IS  - 0002-9629 (Linking)
VI  - 342
IP  - 4
DP  - 2011 Oct
TI  - Is informed consent broken?
PG  - 267-72
LID - 10.1097/MAJ.0b013e31822a6c47 [doi]
AB  - For as long as the federal regulations governing human subjects research have
      existed, the practice of informed consent has been attacked as culturally biased,
      legalistic, ritualistic and unevenly enforced. Its focus on meeting the
      regulatory requirements is seen as undermining a truly ethical process that
      produces informed and voluntary participation in medical research. Recent changes
      in the clinical translational research enterprise, with large scale genomic and
      other data sharing made possible by advanced bioinformatic technologies, may
      further challenge this goal. Study participants are asked to consent to future
      studies with unspecified aims, broad data sharing policies and ongoing
      uncertainties regarding confidentiality protections and the potential benefit of 
      incidental genomic research findings. Because more research is conducted under
      these new conditions, the very nature of the researcher-subject relationship is
      shifting and will require new governance mechanisms to promote the original goals
      of informed consent.
FAU - Henderson, Gail E
AU  - Henderson GE
AD  - Department of Social Medicine, School of Medicine, University of North Carolina
      at Chapel Hill, 333 South Columbia Street, Rm 347 MacNider, Chapel Hill, NC
      2799-7240, USA. ghenders@med.unc.edu
LA  - eng
GR  - P50 HG004488-01/HG/NHGRI NIH HHS/United States
GR  - R01 HG02087/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United States
TA  - Am J Med Sci
JT  - The American journal of the medical sciences
JID - 0370506
SB  - IM
MH  - Bioethical Issues
MH  - Genomics
MH  - Harm Reduction
MH  - Humans
MH  - Informed Consent/*ethics/*legislation & jurisprudence
MH  - Translational Research, Biomedical/ethics/legislation & jurisprudence/trends
EDAT- 2011/08/06 06:00
MHDA- 2011/11/09 06:00
CRDT- 2011/08/06 06:00
PHST- 2011/08/06 06:00 [entrez]
PHST- 2011/08/06 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - 10.1097/MAJ.0b013e31822a6c47 [doi]
AID - S0002-9629(15)31153-8 [pii]
PST - ppublish
SO  - Am J Med Sci. 2011 Oct;342(4):267-72. doi: 10.1097/MAJ.0b013e31822a6c47.


PMID- 21817849
OWN - NLM
STAT- MEDLINE
DCOM- 20111209
LR  - 20211203
IS  - 1349-3329 (Electronic)
IS  - 0040-8727 (Linking)
VI  - 224
IP  - 4
DP  - 2011 Aug
TI  - Building medical ethics education to improve Japanese medical students' attitudes
      toward respecting patients' rights.
PG  - 307-15
AB  - In medical education, it is important for medical students to develop their
      ethics to respect patients' rights. Some physicians might make light of patients'
      rights, because the increased awareness of such rights might make it more
      difficult for them to conduct medical practice. In the present study, predictors 
      significantly associated with "a sense of resistance to patients' rights" were
      examined using anonymous self-administered questionnaires. For these predictors, 
      we produced original items with reference to the concept of ethical development
      and the teachings of Mencius. The subjects were medical students at the Kitasato 
      University School of Medicine, a private university in Japan. A total of 518
      students were analyzed (response rate, 78.4%). The average age of enrolled
      subjects was 22.5 +/- 2.7 years (average age +/- standard deviation). The average
      age of 308 male subjects was 22.7 +/- 2.8 years, while that of 210 female
      subjects was 22.1 +/- 2.5 years. The item, "Excessive measures to pass the
      national examination for medical practitioners," was significantly associated
      with "a sense of resistance to patients' rights." However, other items, including
      basic attributes such as age and gender, were not significant predictors. If
      students spent their school time only focusing on the national examination, they 
      would lose the opportunity to receive the ethical education that would allow them
      to respect patients' rights. That ethical development cannot easily be evaluated 
      with written exams. Thus, along with the acquisition of medical knowledge,
      educational programs to promote medical students' ethics should be developed.
FAU - Saito, Yukiko
AU  - Saito Y
AD  - Department of Medical Humanities, Research and Development Center for Medical
      Education, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
FAU - Kudo, Yasushi
AU  - Kudo Y
FAU - Shibuya, Akitaka
AU  - Shibuya A
FAU - Satoh, Toshihiko
AU  - Satoh T
FAU - Higashihara, Masaaki
AU  - Higashihara M
FAU - Aizawa, Yoshiharu
AU  - Aizawa Y
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Tohoku J Exp Med
JT  - The Tohoku journal of experimental medicine
JID - 0417355
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Asians
MH  - *Attitude of Health Personnel
MH  - Education, Medical/*ethics
MH  - Ethics, Medical/*education
MH  - Female
MH  - Humans
MH  - Japan
MH  - Male
MH  - Patient Rights/*ethics/standards
MH  - *Students, Medical
MH  - Young Adult
EDAT- 2011/08/06 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/08/06 06:00
PHST- 2011/08/06 06:00 [entrez]
PHST- 2011/08/06 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - JST.JSTAGE/tjem/224.307 [pii]
AID - 10.1620/tjem.224.307 [doi]
PST - ppublish
SO  - Tohoku J Exp Med. 2011 Aug;224(4):307-15. doi: 10.1620/tjem.224.307.


PMID- 21816958
OWN - NLM
STAT- MEDLINE
DCOM- 20120824
LR  - 20220309
IS  - 1527-974X (Electronic)
IS  - 1067-5027 (Linking)
VI  - 18 Suppl 1
DP  - 2011 Dec
TI  - The NIAID Division of AIDS enterprise information system: integrated decision
      support for global clinical research programs.
PG  - i161-5
LID - 10.1136/amiajnl-2011-000114 [doi]
AB  - The National Institute of Allergy and Infectious Diseases (NIAID) Division of
      AIDS (DAIDS) Enterprise Information System (DAIDS-ES) is a web-based system that 
      supports NIAID in the scientific, strategic, and tactical management of its
      global clinical research programs for HIV/AIDS vaccines, prevention, and
      therapeutics. Different from most commercial clinical trials information systems,
      which are typically protocol-driven, the DAIDS-ES was built to exchange
      information with those types of systems and integrate it in ways that help
      scientific program directors lead the research effort and keep pace with the
      complex and ever-changing global HIV/AIDS pandemic. Whereas commercially
      available clinical trials support systems are not usually disease-focused,
      DAIDS-ES was specifically designed to capture and incorporate unique scientific, 
      demographic, and logistical aspects of HIV/AIDS treatment, prevention, and
      vaccine research in order to provide a rich source of information to guide
      informed decision-making. Sharing data across its internal components and with
      external systems, using defined vocabularies, open standards and flexible
      interfaces, the DAIDS-ES enables NIAID, its global collaborators and
      stakeholders, access to timely, quality information about NIAID-supported
      clinical trials which is utilized to: (1) analyze the research portfolio, assess 
      capacity, identify opportunities, and avoid redundancies; (2) help support study 
      safety, quality, ethics, and regulatory compliance; (3) conduct evidence-based
      policy analysis and business process re-engineering for improved efficiency. This
      report summarizes how the DAIDS-ES was conceptualized, how it differs from
      typical clinical trial support systems, the rationale for key design choices, and
      examples of how it is being used to advance the efficiency and effectiveness of
      NIAID's HIV/AIDS clinical research programs.
FAU - Kagan, Jonathan M
AU  - Kagan JM
AD  - Division of Clinical Research, Department of Health & Human Services, National
      Institute of Allergy & Infectious Diseases, National Institutes of Health,
      Bethesda, Maryland 20892-7609, USA. jkagan@niaid.nih.gov
FAU - Gupta, Nitin
AU  - Gupta N
FAU - Varghese, Suresh
AU  - Varghese S
FAU - Virkar, Hemant
AU  - Virkar H
LA  - eng
GR  - N01AI30060/AI/NIAID NIH HHS/United States
GR  - N01-AI-30060/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110804
PL  - England
TA  - J Am Med Inform Assoc
JT  - Journal of the American Medical Informatics Association : JAMIA
JID - 9430800
SB  - IM
MH  - *Acquired Immunodeficiency Syndrome
MH  - *Biomedical Research
MH  - HIV Infections
MH  - Humans
MH  - *Information Systems
MH  - *National Institute of Allergy and Infectious Diseases (U.S.)
MH  - Systems Integration
MH  - United States
PMC - PMC3241160
EDAT- 2011/08/06 06:00
MHDA- 2012/08/25 06:00
CRDT- 2011/08/06 06:00
PHST- 2011/08/06 06:00 [entrez]
PHST- 2011/08/06 06:00 [pubmed]
PHST- 2012/08/25 06:00 [medline]
AID - amiajnl-2011-000114 [pii]
AID - 10.1136/amiajnl-2011-000114 [doi]
PST - ppublish
SO  - J Am Med Inform Assoc. 2011 Dec;18 Suppl 1:i161-5. doi:
      10.1136/amiajnl-2011-000114. Epub 2011 Aug 4.


PMID- 21816897
OWN - NLM
STAT- MEDLINE
DCOM- 20120326
LR  - 20211020
IS  - 1465-735X (Electronic)
IS  - 0146-8693 (Linking)
VI  - 36
IP  - 10
DP  - 2011 Nov-Dec
TI  - Commentary: Children and predictive genomic testing: disease prevention, research
      protection, and our future.
PG  - 1113-21
LID - 10.1093/jpepsy/jsr040 [doi]
AB  - Genetic testing offered by direct-to-consumer companies-herein referred to as
      "predictive genomic testing"--has come under federal scrutiny. Critics claim
      testing yields uninterpretable and potentially harmful information. Supporters
      assert individuals have a right to this information, which could catalyze
      preventive health actions. Despite contentions that predictive genomic testing is
      a tool of primary disease prevention, little discussion has focused on its use
      with children. This partly stems from concerns expressed in existing professional
      guidelines about the potential for psychological and behavioral harm to children 
      engendered by predictive genetic tests for Mendelian diseases. Conducting
      research to understand the actual benefits and harms is important for policy
      development and practice guidance and can be ethically justified within the
      pediatric regulatory framework of research that offers a prospect of direct
      benefit. Child health psychologists are well poised to contribute to this
      research effort, and promote the translation of genomic discoveries to improve
      pediatric medicine.
FAU - Tarini, Beth A
AU  - Tarini BA
AD  - Child Health Evaluation and Research Unit, Division of General Pediatrics,
      Department of Pediatrics & Communicable Diseases, University of Michigan, Ann
      Arbor 48109-5456, USA. btarini@umich.edu
FAU - Tercyak, Kenneth P
AU  - Tercyak KP
FAU - Wilfond, Benjamin S
AU  - Wilfond BS
LA  - eng
GR  - P50 HG003374/HG/NHGRI NIH HHS/United States
GR  - R01CA137625/CA/NCI NIH HHS/United States
GR  - UL1RR025014/RR/NCRR NIH HHS/United States
GR  - R01HG002686/HG/NHGRI NIH HHS/United States
GR  - K23HD057994/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110804
PL  - United States
TA  - J Pediatr Psychol
JT  - Journal of pediatric psychology
JID - 7801773
SB  - IM
CIN - J Pediatr Psychol. 2011 Nov-Dec;36(10):1122-7; discussion 1128-9. PMID: 21994422
MH  - Child
MH  - *Child Welfare
MH  - *Ethics, Research
MH  - *Genetic Testing
MH  - Humans
MH  - Risk Assessment
PMC - PMC3199444
EDAT- 2011/08/06 06:00
MHDA- 2012/03/27 06:00
CRDT- 2011/08/06 06:00
PHST- 2011/08/06 06:00 [entrez]
PHST- 2011/08/06 06:00 [pubmed]
PHST- 2012/03/27 06:00 [medline]
AID - jsr040 [pii]
AID - 10.1093/jpepsy/jsr040 [doi]
PST - ppublish
SO  - J Pediatr Psychol. 2011 Nov-Dec;36(10):1113-21. doi: 10.1093/jpepsy/jsr040. Epub 
      2011 Aug 4.


PMID- 21816710
OWN - NLM
STAT- MEDLINE
DCOM- 20120313
LR  - 20110805
IS  - 1538-067X (Electronic)
IS  - 1092-1095 (Linking)
VI  - 15 Suppl
DP  - 2011 Aug
TI  - Sexual dysfunction in multiple myeloma: survivorship care plan of the
      International Myeloma Foundation Nurse Leadership Board.
PG  - 53-65
LID - 10.1188/11.CJON.S1.53-65 [doi]
AB  - The World Health Organization describes sexuality as a "central aspect of being
      human throughout life and encompasses sex, gender identities and roles, sexual
      orientation, eroticism, pleasure, intimacy, and reproduction. Sexuality is
      influenced by the interaction of biological, psychological, social, economic,
      political, cultural, ethical, legal, historical, religious, and spiritual
      factors." Currently, no research has been conducted regarding sexual dysfunction 
      in patients with multiple myeloma; therefore, information related to the
      assessment and evaluation of sexual dysfunction is gleaned from other
      malignancies and diseases. In this article, members of the International Myeloma 
      Foundation's Nurse Leadership Board discuss the definition, presentation, and
      causes of sexual dysfunction; provide recommendations for sexual assessment
      practices; and promote discussion among patients with multiple myeloma, their
      healthcare providers, and their partners.
FAU - Richards, Tiffany A
AU  - Richards TA
AD  - Department of Lymphoma/Myeloma, University of Texas MD Anderson Cancer Center in 
      Houston, USA. tarichards@uwalumni.com
FAU - Bertolotti, Page A
AU  - Bertolotti PA
FAU - Doss, Deborah
AU  - Doss D
FAU - McCullagh, Emily J
AU  - McCullagh EJ
CN  - International Myeloma Foundation Nurse Leadership Board
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin J Oncol Nurs
JT  - Clinical journal of oncology nursing
JID - 9705336
MH  - Humans
MH  - *Leadership
MH  - Multiple Myeloma/complications/nursing/*physiopathology
MH  - *Societies, Nursing
MH  - *Survivors
EDAT- 2011/08/06 06:00
MHDA- 2012/03/14 06:00
CRDT- 2011/08/06 06:00
PHST- 2011/08/06 06:00 [entrez]
PHST- 2011/08/06 06:00 [pubmed]
PHST- 2012/03/14 06:00 [medline]
AID - D017W0M424652XK2 [pii]
AID - 10.1188/11.CJON.S1.53-65 [doi]
PST - ppublish
SO  - Clin J Oncol Nurs. 2011 Aug;15 Suppl:53-65. doi: 10.1188/11.CJON.S1.53-65.


PMID- 21816680
OWN - NLM
STAT- MEDLINE
DCOM- 20120228
LR  - 20111102
IS  - 1938-0690 (Electronic)
IS  - 1525-7304 (Linking)
VI  - 12
IP  - 6
DP  - 2011 Nov
TI  - Costs and ethical issues related to first-line treatment of metastatic
      non-small-cell lung cancer: considerations from a public healthcare system
      perspective.
PG  - 335-40
LID - 10.1016/j.cllc.2011.06.007 [doi]
AB  - Metastatic non-small-cell lung cancer is generally not considered to be curable, 
      and the overall 5-year survival rate is less than 1%. Despite this poor
      prognosis, palliative chemotherapy can increase time and quality of life in the
      advanced-disease setting. New chemotherapy treatments and targeted therapies are 
      available for this stage of disease, but their high costs are an important issue.
      In this perspective article, we discuss the hospital costs of antitumor drug
      administration and the ethical principles involved, the roles of drug agencies
      and oncologists, and relevant current research on these topics. These
      considerations have been examined from the perspective of a national public
      healthcare system.
CI  - Copyright A(c) 2011 Elsevier Inc. All rights reserved.
FAU - Bosch-Barrera, Joaquim
AU  - Bosch-Barrera J
AD  - Department of Medical Oncology, Catalan Institute of Oncology, Doctor Josep
      Trueta University Hospital, Girona, Spain. jbosch@iconcologia.net
FAU - Quer, Nuria
AU  - Quer N
FAU - Brunet, Joan
AU  - Brunet J
LA  - eng
PT  - Journal Article
DEP - 20110803
PL  - United States
TA  - Clin Lung Cancer
JT  - Clinical lung cancer
JID - 100893225
SB  - IM
MH  - Carcinoma, Non-Small-Cell Lung/*economics/secondary/*therapy
MH  - Delivery of Health Care/*economics/*ethics
MH  - Humans
MH  - Lung Neoplasms/*economics/secondary/*therapy
EDAT- 2011/08/06 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/08/06 06:00
PHST- 2011/03/08 00:00 [received]
PHST- 2011/06/02 00:00 [revised]
PHST- 2011/06/08 00:00 [accepted]
PHST- 2011/08/06 06:00 [entrez]
PHST- 2011/08/06 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - S1525-7304(11)00152-5 [pii]
AID - 10.1016/j.cllc.2011.06.007 [doi]
PST - ppublish
SO  - Clin Lung Cancer. 2011 Nov;12(6):335-40. doi: 10.1016/j.cllc.2011.06.007. Epub
      2011 Aug 3.


PMID- 21816531
OWN - NLM
STAT- MEDLINE
DCOM- 20120109
LR  - 20110826
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 73
IP  - 5
DP  - 2011 Sep
TI  - Agency versus structure: genetics, group membership, and a new twist on an old
      debate.
PG  - 632-5
LID - 10.1016/j.socscimed.2011.06.039 [doi]
AB  - The decoding of the human genome and advances in genetic medicine promise great
      advances in the prevention and treatment of disease. These powerful
      methodologies, though, raise serious intellectual, ethical, and practical
      questions when they are employed in explanations of complex higher-order
      behavioral and social outcomes. There can be little doubt that all human behavior
      reflects complex gene/environment interactions, but isolating the unique
      contributions of genes and environment in the explanation of overdetermined
      behavioral and social outcomes may not in principle be possible. When dealing
      with groups that differ significantly in histories of discrimination and
      exclusion biological explanations must be employed with caution even as they
      promise great strides in dealing with specific diseases.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Angel, Ronald J
AU  - Angel RJ
AD  - Department of Sociology, University of Texas, Austin, TX, USA.
      rangel@austin.utexas.edu
LA  - eng
PT  - Journal Article
DEP - 20110723
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
CIN - Soc Sci Med. 2011 Sep;73(5):639-42; discussion 643-4. PMID: 21816530
CIN - Soc Sci Med. 2011 Sep;73(5):636-8; discussion 643-4. PMID: 21824699
MH  - Eugenics
MH  - *Genetic Research
MH  - Genetic Testing
MH  - Genome, Human
MH  - Humans
MH  - Molecular Biology
MH  - Population Groups/*genetics
MH  - *Terminology as Topic
EDAT- 2011/08/06 06:00
MHDA- 2012/01/10 06:00
CRDT- 2011/08/06 06:00
PHST- 2010/08/11 00:00 [received]
PHST- 2011/03/17 00:00 [revised]
PHST- 2011/06/24 00:00 [accepted]
PHST- 2011/08/06 06:00 [entrez]
PHST- 2011/08/06 06:00 [pubmed]
PHST- 2012/01/10 06:00 [medline]
AID - S0277-9536(11)00407-2 [pii]
AID - 10.1016/j.socscimed.2011.06.039 [doi]
PST - ppublish
SO  - Soc Sci Med. 2011 Sep;73(5):632-5. doi: 10.1016/j.socscimed.2011.06.039. Epub
      2011 Jul 23.


PMID- 21816353
OWN - NLM
STAT- MEDLINE
DCOM- 20120110
LR  - 20211020
IS  - 1528-8447 (Electronic)
IS  - 1526-5900 (Linking)
VI  - 12
IP  - 8
DP  - 2011 Aug
TI  - Factors affecting placebo acceptability: deception, outcome, and disease
      severity.
PG  - 920-8
LID - 10.1016/j.jpain.2011.02.353 [doi]
AB  - UNLABELLED: A burgeoning body of evidence supports the efficacy and elucidates
      the mechanisms of placebo analgesia. Debate persists, however, concerning their
      ethical use, with many of the present arguments being philosophically based. The 
      present web-based study empirically investigated the acceptability of an
      analgesic placebo treatment. Participants (103) responded to vignettes depicting 
      patients receiving a placebo analgesic. We experimentally manipulated: 1) placebo
      treatment instructions (level of deception); 2) treatment outcome; and 3)
      patients' pain severity. Participants rated vignettes on outcome measures of
      deception, physician-patient relationship, and patient mood. Participants then
      characterized a range of placebo acceptability through ratings of deceptiveness, 
      effectiveness, and negative consequences. Results showed that placebos described 
      as "medication shown to be a powerful analgesic in some people" were equally
      deceptive as those described as "standard drug treatment." Ratings of patient
      mood and physician approval were determined as much by treatment instruction as
      by treatment outcome and an analgesic response mitigated the negative
      consequences of deceptive administration. Participants tolerated moderate
      effectiveness and considerable negative consequences in an acceptable placebo,
      although results suggest lay individuals may not have a sophisticated
      conceptualization of placebo effectiveness. Studies altering individuals'
      understanding of placebo effectiveness and mechanisms are needed to identify
      additional factors determining placebo acceptability. PERSPECTIVE: This study
      represents an empirical examination of analgesic placebo acceptability among lay 
      individuals. This article is the first to systematically manipulate deception,
      treatment outcome, and disease severity to determine how these factors interact
      to differentially determine placebo acceptability-a highly relevant finding that 
      informs the clinical use of placebo.
CI  - Copyright (c) 2011 American Pain Society. Published by Elsevier Inc. All rights
      reserved.
FAU - Kisaalita, Nkaku R
AU  - Kisaalita NR
AD  - Center for Pain Research and Behavioral Health, Department of Clinical and Health
      Psychology, University of Florida, Gainesville, FL 32610, USA.
FAU - Roditi, Daniela
AU  - Roditi D
FAU - Robinson, Michael E
AU  - Robinson ME
LA  - eng
GR  - R01 AT001424/AT/NCCIH NIH HHS/United States
GR  - R01 AT001424-07/AT/NCCIH NIH HHS/United States
GR  - 5R01AT001424-06/AT/NCCIH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Pain
JT  - The journal of pain
JID - 100898657
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Analysis of Variance
MH  - *Deception
MH  - Female
MH  - Humans
MH  - Male
MH  - Mood Disorders/etiology
MH  - Pain/*drug therapy/*psychology
MH  - Pain Measurement
MH  - *Patient Acceptance of Health Care
MH  - Physician-Patient Relations
MH  - *Placebo Effect
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC3150516
MID - NIHMS282874
EDAT- 2011/08/06 06:00
MHDA- 2012/01/11 06:00
CRDT- 2011/08/06 06:00
PHST- 2010/10/06 00:00 [received]
PHST- 2010/12/26 00:00 [revised]
PHST- 2011/02/18 00:00 [accepted]
PHST- 2011/08/06 06:00 [entrez]
PHST- 2011/08/06 06:00 [pubmed]
PHST- 2012/01/11 06:00 [medline]
AID - S1526-5900(11)00448-2 [pii]
AID - 10.1016/j.jpain.2011.02.353 [doi]
PST - ppublish
SO  - J Pain. 2011 Aug;12(8):920-8. doi: 10.1016/j.jpain.2011.02.353.


PMID- 21816301
OWN - NLM
STAT- MEDLINE
DCOM- 20111004
LR  - 20110805
IS  - 1558-3597 (Electronic)
IS  - 0735-1097 (Linking)
VI  - 58
IP  - 7
DP  - 2011 Aug 9
TI  - International participation in cardiovascular randomized controlled trials
      sponsored by the National Heart, Lung, and Blood Institute.
PG  - 671-6
LID - 10.1016/j.jacc.2011.01.066 [doi]
AB  - OBJECTIVES: The aim of this study was to describe international enrollment and
      participation in National Institutes of Health (NIH)-sponsored cardiovascular
      randomized controlled trials (RCTs). BACKGROUND: RCTs provide the evidence base
      for major societal guidelines and profoundly influence patient care in the United
      States. Increased international involvement in clinical trials has been observed,
      but the rate of international enrollment in NIH-sponsored cardiovascular RCTs has
      not been described. METHODS: The NIH registry of clinical trials was searched for
      phase III or IV cardiovascular RCTs funded by the National Heart, Lung, and Blood
      Institute. Studies with outcomes of myocardial infarction, stroke, or death
      published between 1997 and 2009 were included. Rates of international enrollment 
      were obtained from published data or personal communication with corresponding
      authors. RESULTS: Twenty-four studies met all inclusion criteria. Nineteen trials
      including 151,682 patients had international participation (IP), with median IP
      of 9.5% (range 0% to 100%). Coronary artery disease trials (11 studies) had
      nearly 50% international enrollment. High-risk trials and trials testing acute
      interventions tended to have higher rates of IP. CONCLUSIONS: Cardiovascular RCTs
      sponsored by the National Heart, Lung, and Blood Institute have substantial rates
      of international enrollment, particularly coronary artery disease trials. Given
      questions of applicability and ethical and financial considerations, IP in U.S.
      clinical trials deserves further scrutiny.
CI  - Copyright (c) 2011 American College of Cardiology Foundation. Published by
      Elsevier Inc. All rights reserved.
FAU - Kim, Esther S H
AU  - Kim ES
AD  - Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio, USA.
FAU - Carrigan, Thomas P
AU  - Carrigan TP
FAU - Menon, Venu
AU  - Menon V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Am Coll Cardiol
JT  - Journal of the American College of Cardiology
JID - 8301365
SB  - IM
CIN - J Am Coll Cardiol. 2011 Aug 9;58(7):677-80. PMID: 21816302
MH  - *Cardiovascular Diseases
MH  - Clinical Trials, Phase III as Topic
MH  - Clinical Trials, Phase IV as Topic
MH  - Humans
MH  - *Internationality
MH  - *Multicenter Studies as Topic
MH  - *National Heart, Lung, and Blood Institute (U.S.)
MH  - Patient Selection
MH  - *Randomized Controlled Trials as Topic
MH  - *Research Support as Topic
MH  - United States
EDAT- 2011/08/06 06:00
MHDA- 2011/10/05 06:00
CRDT- 2011/08/06 06:00
PHST- 2010/11/22 00:00 [received]
PHST- 2011/01/20 00:00 [revised]
PHST- 2011/01/26 00:00 [accepted]
PHST- 2011/08/06 06:00 [entrez]
PHST- 2011/08/06 06:00 [pubmed]
PHST- 2011/10/05 06:00 [medline]
AID - S0735-1097(11)01877-8 [pii]
AID - 10.1016/j.jacc.2011.01.066 [doi]
PST - ppublish
SO  - J Am Coll Cardiol. 2011 Aug 9;58(7):671-6. doi: 10.1016/j.jacc.2011.01.066.


PMID- 21815972
OWN - NLM
STAT- MEDLINE
DCOM- 20120131
LR  - 20110928
IS  - 1365-2753 (Electronic)
IS  - 1356-1294 (Linking)
VI  - 17
IP  - 5
DP  - 2011 Oct
TI  - Virtuous acts as practical medical ethics: an empirical study.
PG  - 948-53
LID - 10.1111/j.1365-2753.2011.01730.x [doi]
AB  - RATIONALE, AIMS AND OBJECTIVES: To examine the nature, scope and significance of 
      virtues in the biographies of medical practitioners and to determine what kind of
      virtues are at play in their ethical behaviour and reflection. METHODS: A case
      study involving 19 medical practitioners associated with the Sydney Medical
      School, using semi-structured narrative interviews. Narrative data were analysed 
      using dialectical empiricism, constant comparison and iterative reformulation of 
      research questions. RESULTS: Participants represented virtuous acts as centrally 
      important in their moral assessments of both themselves and others. Acts appeared
      to be contextually virtuous, rather than expressions of stable character traits, 
      and virtue was linked to acts that served to protect or enhance fundamental
      values attached to ontological security and human flourishing. Virtue ethics, in 
      this sense, was the single most important ethical system for each of the
      participants. CONCLUSION: Virtue ethics, construed as the appraisal of acts in
      contexts of risk, danger or threat to foundational values, emerged as the
      'natural' ethical approach for medical practitioners in this case study. Teaching
      medical ethics to students and graduates alike needs to accommodate the priority 
      attached to virtuous acts.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Little, Miles
AU  - Little M
AD  - Centre for Values, Ethics and Law in Medicine, Sydney Medical School, University 
      of Sydney, Sydney, NSW, Australia. miles.little@sydney.edu.au
FAU - Gordon, Jill
AU  - Gordon J
FAU - Markham, Pippa
AU  - Markham P
FAU - Rychetnik, Lucie
AU  - Rychetnik L
FAU - Kerridge, Ian
AU  - Kerridge I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110804
PL  - England
TA  - J Eval Clin Pract
JT  - Journal of evaluation in clinical practice
JID - 9609066
SB  - IM
CIN - J Eval Clin Pract. 2011 Oct;17(5):954-6. PMID: 21951928
MH  - Decision Making
MH  - Ethical Theory
MH  - *Ethics, Clinical
MH  - Humans
MH  - Interviews as Topic
MH  - Qualitative Research
MH  - *Virtues
EDAT- 2011/08/06 06:00
MHDA- 2012/02/01 06:00
CRDT- 2011/08/06 06:00
PHST- 2011/08/06 06:00 [entrez]
PHST- 2011/08/06 06:00 [pubmed]
PHST- 2012/02/01 06:00 [medline]
AID - 10.1111/j.1365-2753.2011.01730.x [doi]
PST - ppublish
SO  - J Eval Clin Pract. 2011 Oct;17(5):948-53. doi: 10.1111/j.1365-2753.2011.01730.x. 
      Epub 2011 Aug 4.


PMID- 21815969
OWN - NLM
STAT- MEDLINE
DCOM- 20120131
LR  - 20110928
IS  - 1365-2753 (Electronic)
IS  - 1356-1294 (Linking)
VI  - 17
IP  - 5
DP  - 2011 Oct
TI  - Evidence-based medicine and epistemological imperialism: narrowing the divide
      between evidence and illness.
PG  - 868-72
LID - 10.1111/j.1365-2753.2011.01723.x [doi]
AB  - Evidence-based medicine (EBM) has been rapidly and widely adopted because it
      claims to provide a method for determining the safety and efficacy of medical
      therapies and public health interventions more generally. However, as others have
      noted, EBM may be riven through with cultural bias, both in the generation of
      evidence and in its translation. We suggest that technological and scientific
      advances in medicine accentuate and entrench these cultural biases, to the extent
      that they may invalidate the evidence we have about disease and its treatment.
      This creates a significant ethical, epistemological and ontological challenge for
      medicine.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Crowther, Helen
AU  - Crowther H
AD  - Department of Medicine, Westmead Hospital, Sydney, New South Wales, Australia.
FAU - Lipworth, Wendy
AU  - Lipworth W
FAU - Kerridge, Ian
AU  - Kerridge I
LA  - eng
PT  - Journal Article
DEP - 20110804
PL  - England
TA  - J Eval Clin Pract
JT  - Journal of evaluation in clinical practice
JID - 9609066
SB  - IM
MH  - Biomedical Research/ethics/*organization & administration
MH  - *Cultural Characteristics
MH  - Cytogenetic Analysis
MH  - Evidence-Based Medicine/ethics/*organization & administration
MH  - Humans
MH  - Leukemia/classification
MH  - Philosophy, Medical
MH  - Randomized Controlled Trials as Topic
MH  - Research Design
EDAT- 2011/08/06 06:00
MHDA- 2012/02/01 06:00
CRDT- 2011/08/06 06:00
PHST- 2011/08/06 06:00 [entrez]
PHST- 2011/08/06 06:00 [pubmed]
PHST- 2012/02/01 06:00 [medline]
AID - 10.1111/j.1365-2753.2011.01723.x [doi]
PST - ppublish
SO  - J Eval Clin Pract. 2011 Oct;17(5):868-72. doi: 10.1111/j.1365-2753.2011.01723.x. 
      Epub 2011 Aug 4.


PMID- 21815815
OWN - NLM
STAT- MEDLINE
DCOM- 20120606
LR  - 20151119
IS  - 1557-7740 (Electronic)
IS  - 1557-7740 (Linking)
VI  - 15
IP  - 1
DP  - 2012 Jan
TI  - Case report: are clinicians obligated to medically treat a suicide attempt in a
      patient with a prognosis of weeks?
PG  - 134-7
LID - 10.1089/jpm.2010.0530 [doi]
AB  - BACKGROUND: There is broad ethical and professional consensus that preventing a
      patient from initiating or successfully completing a suicide attempt is a core
      physician obligation and justifies the use of aggressive interventions such as
      emergency detention and mechanical ventilation. This case examines the acute
      medical care of an individual with a progressive brain tumor after an apparent
      suicide attempt. RESULTS: In guiding the care of this patient, we found that the 
      patient's prognosis of days to weeks made the ethical rationale of implementing
      aggressive medical interventions to treat the sequelae of his suicide attempt
      less compelling.
FAU - Marks, Sean
AU  - Marks S
AD  - Department of Hematology and Oncology, Medical College of Wisconsin, Milwaukee,
      Wisconsin 53226, USA. smarks@mcw.edu
FAU - Heinrich, Thomas W
AU  - Heinrich TW
FAU - Rosielle, Drew
AU  - Rosielle D
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20110804
PL  - United States
TA  - J Palliat Med
JT  - Journal of palliative medicine
JID - 9808462
SB  - IM
MH  - Aged
MH  - Brain Neoplasms
MH  - Critical Care/*ethics
MH  - Humans
MH  - Male
MH  - Patients/*psychology
MH  - Prognosis
MH  - *Suicide, Attempted
MH  - Terminally Ill/*psychology
EDAT- 2011/08/06 06:00
MHDA- 2012/06/07 06:00
CRDT- 2011/08/06 06:00
PHST- 2011/08/06 06:00 [entrez]
PHST- 2011/08/06 06:00 [pubmed]
PHST- 2012/06/07 06:00 [medline]
AID - 10.1089/jpm.2010.0530 [doi]
PST - ppublish
SO  - J Palliat Med. 2012 Jan;15(1):134-7. doi: 10.1089/jpm.2010.0530. Epub 2011 Aug 4.


PMID- 21815574
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20220408
IS  - 1938-2367 (Electronic)
IS  - 0147-7447 (Linking)
VI  - 34
IP  - 8
DP  - 2011 Aug 8
TI  - A biomechanical comparison of patellar tendon repair materials in a bovine model.
PG  - e344-8
LID - 10.3928/01477447-20110627-13 [doi]
AB  - We evaluated the biomechanical properties of FiberWire (Arthrex, Inc, Naples,
      Florida), a new suture material, for both repair and augmentation as compared to 
      standard Ethibond suture (Ethicon, Inc, Somerville, New Jersey), hypothesizing
      that primary repair and cerclage augmentation with the new suture material would 
      have similar biomechanical properties as a standard repair with wire
      augmentation. Forty-five fresh bovine knees were placed in 3 groups of equal
      size: (1) #5 Ethibond tendon repair plus 18-gauge wire augmentation; (2) #5
      FiberWire repair plus #5 FiberWire augmentation; and (3) #5 Ethibond repair plus 
      #5 FiberWire augmentation. A straight static pullout test was performed, randomly
      alternating between the different groups. Gap formation was measured at the
      center of the repair by a metric ruler, with the examiner blinded to the
      developing force-tension readout. For each millimeter of gap formation (1-10 mm),
      the force on the repair was recorded, as well as the force at the ultimate
      failure of the repair, designated by breakage of any repair material. Analysis
      showed no significant difference between the standard Ethibond/wire repair and
      the FiberWire/FiberWire repair. The Ethibond/FiberWire repair was shown to be
      significantly weaker than the other 2 groups. Ultimate failure data indicated
      that the Ethibond/wire repair was significantly stronger than both other groups. 
      No significant differences were found between the FiberWire/FiberWire repair and 
      the Ethibond/FiberWire repair. Newer, stronger suture material for both primary
      repair and augmentation may provide equivalent biomechanical strength at
      clinically significant levels.
CI  - Copyright 2011, SLACK Incorporated.
FAU - Flanigan, David C
AU  - Flanigan DC
AD  - Department of Orthopedics, Sports Medicine Center, The Ohio State University,
      Columbus, Ohio 43221, USA. david.fl anigan@osumc.edu
FAU - Bloomfield, Michael
AU  - Bloomfield M
FAU - Koh, Jason
AU  - Koh J
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
DEP - 20110808
PL  - United States
TA  - Orthopedics
JT  - Orthopedics
JID - 7806107
SB  - IM
MH  - Animals
MH  - Biomechanical Phenomena/physiology
MH  - *Bone Wires
MH  - Cattle
MH  - Disease Models, Animal
MH  - Elasticity
MH  - *Equipment Failure Analysis
MH  - Patellar Ligament/injuries/*surgery
MH  - Reconstructive Surgical Procedures/instrumentation/*methods
MH  - Stifle/physiopathology/surgery
MH  - *Sutures
MH  - Tendon Injuries/*surgery
MH  - Tensile Strength
EDAT- 2011/08/06 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/08/06 06:00
PHST- 2011/08/06 06:00 [entrez]
PHST- 2011/08/06 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.3928/01477447-20110627-13 [doi]
PST - epublish
SO  - Orthopedics. 2011 Aug 8;34(8):e344-8. doi: 10.3928/01477447-20110627-13.


PMID- 21814663
OWN - NLM
STAT- MEDLINE
DCOM- 20130708
LR  - 20110804
IS  - 0300-8495 (Print)
IS  - 0300-8495 (Linking)
VI  - 40
IP  - 8
DP  - 2011 Aug
TI  - Understanding insurance - the GP's professional and ethical responsibilities.
PG  - 631-3
AB  - BACKGROUND: General practitioners will often consult with patients in situations 
      where professional skill is required to support a decision regarding insurance.
      OBJECTIVE: The aim of this article is to assist doctors' understanding of the
      basis of insurance and risk, in order to support their own practice in this
      important area. DISCUSSION: This article provides information about insurance and
      the professional skills required to assist in decisions made by insurance
      companies (for which, commercial factors predominate), and/or by patients (in
      whom, social and emotional factors may be more important). A quality improvement 
      activity is provided for those interested in making changes to their practice.
FAU - Seidl, Isaac
AU  - Seidl I
AD  - School of Public Health, Tropical Medicine and Rehabilitation Sciences, James
      Cook University, Townsville, Queensland. isaac.seidl@jcu.edu.au
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Aust Fam Physician
JT  - Australian family physician
JID - 0326701
SB  - IM
MH  - Australia
MH  - Confidentiality
MH  - Ethics, Medical
MH  - General Practice
MH  - Humans
MH  - *Insurance/ethics
MH  - *Physician's Role
MH  - Physician-Patient Relations
MH  - Risk Assessment
MH  - Social Responsibility
EDAT- 2011/08/05 06:00
MHDA- 2013/07/09 06:00
CRDT- 2011/08/05 06:00
PHST- 2011/08/05 06:00 [entrez]
PHST- 2011/08/05 06:00 [pubmed]
PHST- 2013/07/09 06:00 [medline]
PST - ppublish
SO  - Aust Fam Physician. 2011 Aug;40(8):631-3.


PMID- 21814138
OWN - NLM
STAT- MEDLINE
DCOM- 20120113
LR  - 20151119
IS  - 1536-3724 (Electronic)
IS  - 1050-642X (Linking)
VI  - 21
IP  - 5
DP  - 2011 Sep
TI  - Growth hormone abuse and biological passport: is mannan-binding lectin a
      complementary candidate?
PG  - 441-3
LID - 10.1097/JSM.0b013e318221f6e4 [doi]
AB  - OBJECTIVE: In the detection of human growth hormone (GH) abuse, the approach
      based on altered GH-related biomarkers is also being considered with respect to
      its application within the context of a biological passport. As a potential
      biomarker, mannan-binding lectin (MBL), which is reported to respond to
      recombinant GH (rGH) administration, is evaluated here. DESIGN: Randomized and
      single blind and approved by the Ethical Committee (Comite Etico de Investigacion
      Clinica-Instituto Municipal de Asistencia Sanitaria). PARTICIPANTS: One group of 
      12 male subjects (24.2 +/- 2.2 years; 76.1 +/- 6.1 kg) was studied.
      INTERVENTIONS: Mannan-binding lectin concentration was measured in 12 healthy
      individuals after subcutaneous daily doses of 6 IU of rGH administration.
      Mannan-binding lectin serum concentration increased after rGH administration.
      Mannan-binding lectin concentration increases were observed 48 hours after the
      first administration and remained elevated for several days after the final dose.
      MAIN OUTCOME MEASURES: Mannan-binding lectin concentration increase and elapsed
      time to recover initial MBL values after the last rGH administration. RESULTS:
      Absolute values displayed high interindividual variability, and 1 individual did 
      not show any MBL increase (potential MBL deficiency). Mannan-binding lectin
      protein showed a clear concentration increase after continued rGH administration,
      despite the high heterogeneity found between individuals. CONCLUSIONS: The use of
      MBL as a complementary GH-related biomarker could be of interest, taking
      advantage of the high increases (up to 700%) and the relatively slow recovery
      time.
FAU - Such-Sanmartin, Gerard
AU  - Such-Sanmartin G
AD  - Bio-Analysis Research Group, Neuropsychopharmacology Program, IMIM-Hospital del
      Mar, PRBB, Barcelona, Spain.
FAU - Bosch, Jaume
AU  - Bosch J
FAU - Segura, Jordi
AU  - Segura J
FAU - Gutierrez-Gallego, Ricardo
AU  - Gutierrez-Gallego R
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Clin J Sport Med
JT  - Clinical journal of sport medicine : official journal of the Canadian Academy of 
      Sport Medicine
JID - 9103300
RN  - 0 (Biomarkers)
RN  - 0 (Mannose-Binding Lectin)
RN  - 0 (Recombinant Proteins)
RN  - 12629-01-5 (Human Growth Hormone)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Doping in Sports/*prevention & control
MH  - *Human Growth Hormone
MH  - Humans
MH  - Male
MH  - Mannose-Binding Lectin/*blood
MH  - Recombinant Proteins
MH  - Single-Blind Method
MH  - Substance Abuse Detection/*methods
MH  - Substance-Related Disorders/*diagnosis
MH  - Young Adult
EDAT- 2011/08/05 06:00
MHDA- 2012/01/14 06:00
CRDT- 2011/08/05 06:00
PHST- 2011/08/05 06:00 [entrez]
PHST- 2011/08/05 06:00 [pubmed]
PHST- 2012/01/14 06:00 [medline]
AID - 10.1097/JSM.0b013e318221f6e4 [doi]
PST - ppublish
SO  - Clin J Sport Med. 2011 Sep;21(5):441-3. doi: 10.1097/JSM.0b013e318221f6e4.


PMID- 21814079
OWN - NLM
STAT- MEDLINE
DCOM- 20111111
LR  - 20110804
IS  - 1539-736X (Electronic)
IS  - 0022-3018 (Linking)
VI  - 199
IP  - 8
DP  - 2011 Aug
TI  - Psychiatric ethics: foundational and evolutionary.
PG  - 562-6
LID - 10.1097/NMD.0b013e318225f0fe [doi]
AB  - As with the basic and clinical sciences, the field of medical ethics, in
      particular, that of psychiatric ethics, has grown and developed during the last
      four decades, the time when Dr. Eugene Brody edited the Journal of Nervous and
      Mental Disease. In this paper, the authors will consider a series of ethical
      problems that psychiatrists have identified in their clinical practice and
      suggest paths to resolution that may artfully balance conflicts in core moral
      beliefs.
FAU - Eth, Spencer
AU  - Eth S
AD  - Psychiatry Service, VA Medical Center, USA. spenceth@pol.net
FAU - Leong, Gregory B
AU  - Leong GB
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Nerv Ment Dis
JT  - The Journal of nervous and mental disease
JID - 0375402
SB  - IM
MH  - Ethics, Research/education
MH  - Humans
MH  - Informed Consent/ethics
MH  - Psychiatry/education/*ethics
EDAT- 2011/08/05 06:00
MHDA- 2011/11/15 06:00
CRDT- 2011/08/05 06:00
PHST- 2011/08/05 06:00 [entrez]
PHST- 2011/08/05 06:00 [pubmed]
PHST- 2011/11/15 06:00 [medline]
AID - 10.1097/NMD.0b013e318225f0fe [doi]
AID - 00005053-201108000-00009 [pii]
PST - ppublish
SO  - J Nerv Ment Dis. 2011 Aug;199(8):562-6. doi: 10.1097/NMD.0b013e318225f0fe.


PMID- 21814075
OWN - NLM
STAT- MEDLINE
DCOM- 20111111
LR  - 20110804
IS  - 1539-736X (Electronic)
IS  - 0022-3018 (Linking)
VI  - 199
IP  - 8
DP  - 2011 Aug
TI  - Psychiatry and terrorism.
PG  - 537-43
LID - 10.1097/NMD.0b013e318225ee90 [doi]
AB  - Terrorism has dominated the domestic and international landscape since 9/11. Like
      other fields, psychiatry was not well prepared. With the 10th anniversary of the 
      9/11 attack approaching, it is timely to consider what can be done to prepare
      before the next event. Much has been learned to provide knowledge and resources. 
      The roles of psychiatrists are challenged by what is known of the causes of,
      consequences of, and responses to terrorism. Reflecting on knowledge from before 
      and since 9/11 introduces concepts, how individuals become terrorists, how to
      evaluate the psychiatric and behavioral effects of terrorism, and how to expand
      treatments, behavioral health interventions, public policy initiatives, and other
      responses for its victims. New research, clinical approaches, and policy
      perspectives inform strategies to reduce fear and cope with the aftermath. This
      article identifies the psychiatric training, skills and services, and ethical
      considerations necessary to prevent or reduce terrorism and its tragic
      consequences and to enhance resilience.
FAU - Stoddard, Frederick J Jr
AU  - Stoddard FJ Jr
AD  - Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA.
      FStoddard@partners.org
FAU - Gold, Joel
AU  - Gold J
FAU - Henderson, Schuyler W
AU  - Henderson SW
FAU - Merlino, Joseph P
AU  - Merlino JP
FAU - Norwood, Ann
AU  - Norwood A
FAU - Post, Jerrold M
AU  - Post JM
FAU - Shanfield, Stephen
AU  - Shanfield S
FAU - Weine, Stevan
AU  - Weine S
FAU - Katz, Craig L
AU  - Katz CL
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Nerv Ment Dis
JT  - The Journal of nervous and mental disease
JID - 0375402
SB  - IM
MH  - Disasters
MH  - Humans
MH  - Life Change Events
MH  - Mental Health Services
MH  - Psychotherapy/*methods
MH  - Stress Disorders, Post-Traumatic/psychology/*therapy
MH  - Terrorism/*psychology
EDAT- 2011/08/05 06:00
MHDA- 2011/11/15 06:00
CRDT- 2011/08/05 06:00
PHST- 2011/08/05 06:00 [entrez]
PHST- 2011/08/05 06:00 [pubmed]
PHST- 2011/11/15 06:00 [medline]
AID - 10.1097/NMD.0b013e318225ee90 [doi]
AID - 00005053-201108000-00005 [pii]
PST - ppublish
SO  - J Nerv Ment Dis. 2011 Aug;199(8):537-43. doi: 10.1097/NMD.0b013e318225ee90.


PMID- 21813741
OWN - NLM
STAT- MEDLINE
DCOM- 20111109
LR  - 20151119
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 261
IP  - 1
DP  - 2011 Oct
TI  - Chronic obstructive pulmonary disease: quantification of bronchodilator effects
      by using hyperpolarized (3)He MR imaging.
PG  - 283-92
LID - 10.1148/radiol.11110403 [doi]
AB  - PURPOSE: To evaluate short-acting bronchodilator effects in chronic obstructive
      pulmonary disease (COPD) by using hyperpolarized helium 3 ((3)He) magnetic
      resonance (MR) imaging, spirometry, and plethysmography. MATERIALS AND METHODS:
      Fourteen ex-smokers with COPD provided written informed consent to a local ethics
      board-approved and Health Insurance and Portability Accountability Act-compliant 
      protocol and underwent hyperpolarized (3)He and hydrogen 1 MR imaging,
      spirometry, and plethysmography before and a mean of 25 minutes +/- 2 (standard
      deviation) after administration of 400 mug salbutamol. Distribution of (3)He gas 
      was evaluated by using semiautomated segmentation of (3)He voxel intensities,
      where cluster 1 represented regions of signal void or ventilation defect volume
      (VDV), and clusters 2-5 (C2-C5) represented gradations of signal intensity from
      hypointensity (C2) to hyperintensity (C5). (3)He ventilation defect percentage
      (VDP) was calculated as VDV normalized to the thoracic cavity volume. Comparisons
      of pre- and post-salbutamol means were performed by using a two-way mixed-design 
      repeated measures analysis of variance, and comparisons of the magnitude of the
      treatment effect between pulmonary function and (3)He MR imaging measurements
      were performed by using effect size (ES) calculations. The relationships between 
      pulmonary function and (3)He MR imaging findings were determined by using
      Spearman correlation coefficients. RESULTS: After salbutamol administration,
      there were significant changes in forced expiratory volume in 1 second (FEV(1))
      (P = .001), total lung capacity (P = .04), and functional residual capacity (P = 
      .03), as well as VDP (P < .0001) and (3)He gas distribution (C2, P = .01; C3, P =
      .03; C4, P < .0001; and C5, P = .02). Treatment ES was greater for (3)He VDP than
      for FEV(1) (0.50 vs 0.22). There was a significant correlation between baseline
      VDP and post-salbutamol FEV(1) change (r = -0.77, P = .001). Although five
      patients were classified as bronchodilator responders and nine patients were
      classified as bronchodilator nonresponders according to American Thoracic Society
      and European Respiratory Society criteria, there was no significant difference in
      the magnitude of the (3)He MR imaging changes after salbutamol administration
      between responder groups. CONCLUSION: (3)He MR imaging depicted significant
      improvements in the distribution of (3)He gas after bronchodilator therapy in
      ex-smokers with COPD with and those without clinically important changes in
      FEV(1).
CI  - (c) RSNA, 2011.
FAU - Kirby, Miranda
AU  - Kirby M
AD  - Imaging Research Laboratories, Robarts Research Institute, London, ON, Canada.
FAU - Mathew, Lindsay
AU  - Mathew L
FAU - Heydarian, Mohammadreza
AU  - Heydarian M
FAU - Etemad-Rezai, Roya
AU  - Etemad-Rezai R
FAU - McCormack, David G
AU  - McCormack DG
FAU - Parraga, Grace
AU  - Parraga G
LA  - eng
PT  - Journal Article
DEP - 20110803
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Bronchodilator Agents)
RN  - 0 (Isotopes)
RN  - 206GF3GB41 (Helium)
RN  - QF8SVZ843E (Albuterol)
SB  - IM
MH  - Aged
MH  - Albuterol/*therapeutic use
MH  - Bronchodilator Agents/*therapeutic use
MH  - Female
MH  - Helium
MH  - Humans
MH  - Isotopes
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Disease, Chronic Obstructive/*diagnosis/*drug therapy/physiopathology
MH  - Respiratory Function Tests
EDAT- 2011/08/05 06:00
MHDA- 2011/11/10 06:00
CRDT- 2011/08/05 06:00
PHST- 2011/08/05 06:00 [entrez]
PHST- 2011/08/05 06:00 [pubmed]
PHST- 2011/11/10 06:00 [medline]
AID - radiol.11110403 [pii]
AID - 10.1148/radiol.11110403 [doi]
PST - ppublish
SO  - Radiology. 2011 Oct;261(1):283-92. doi: 10.1148/radiol.11110403. Epub 2011 Aug 3.


PMID- 21813248
OWN - NLM
STAT- MEDLINE
DCOM- 20120327
LR  - 20111007
IS  - 1873-4111 (Electronic)
IS  - 0378-5122 (Linking)
VI  - 70
IP  - 3
DP  - 2011 Nov
TI  - Fertility after age 45: From natural conception to Assisted Reproductive
      Technology and beyond.
PG  - 216-21
LID - 10.1016/j.maturitas.2011.07.003 [doi]
AB  - The introduction of in vitro fertilization (IVF) in 1978 - an accomplishment
      awarded with the 2010 Nobel Prize in Physiology or Medicine - has revolutionized 
      the lives of millions of couples previously unable to conceive. Though initially 
      applied primarily to young women with blocked Fallopian tubes, over the past
      three decades IVF has been increasingly used to combat age-related infertility.
      It has become clear that the decline in fertility with increasing female age is
      largely due to a rapid decrease in oocyte (egg) quantity and quality, with a
      higher proportion of oocytes displaying genetic abnormalities. Despite
      significant improvements in medical stimulation and laboratory culturing of
      embryos, IVF success once women reach the age of 45 is exceedingly rare. It has
      been well established through elegant clinical studies that, unlike the ovary,
      the reproductive capacity of the uterus does not diminish with age, even into the
      late 40s and 50s. With the use of oocytes from younger donors, women who are
      menopausal can attain very high rates of conception. The increased obstetrical
      risks in this population, which has a higher risk of underlying medical
      co-morbidities, must be considered prior to attempts at assisted conception,
      often in consultation with a multidisciplinary team of physicians. Finally,
      attempts to reverse the age-related decline in oocyte quality through
      micro-manipulation of the nucleus and cytoplasm have yielded disappointing
      results and are fraught with ethical concerns.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Forman, Eric J
AU  - Forman EJ
AD  - Reproductive Medicine Associates of New Jersey, 111 Madison Avenue, Suite 100,
      Morristown, NJ 07960, USA. eforman@rmanj.com
FAU - Treff, Nathan R
AU  - Treff NR
FAU - Scott, Richard T Jr
AU  - Scott RT Jr
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110802
PL  - Ireland
TA  - Maturitas
JT  - Maturitas
JID - 7807333
SB  - IM
MH  - Aging/*physiology
MH  - Female
MH  - *Fertility
MH  - Fertilization
MH  - *Fertilization in Vitro
MH  - Humans
MH  - Menopause
MH  - Middle Aged
MH  - Oocytes/physiology
MH  - Uterus/physiology
EDAT- 2011/08/05 06:00
MHDA- 2012/03/28 06:00
CRDT- 2011/08/05 06:00
PHST- 2011/07/06 00:00 [received]
PHST- 2011/07/08 00:00 [accepted]
PHST- 2011/08/05 06:00 [entrez]
PHST- 2011/08/05 06:00 [pubmed]
PHST- 2012/03/28 06:00 [medline]
AID - S0378-5122(11)00237-4 [pii]
AID - 10.1016/j.maturitas.2011.07.003 [doi]
PST - ppublish
SO  - Maturitas. 2011 Nov;70(3):216-21. doi: 10.1016/j.maturitas.2011.07.003. Epub 2011
      Aug 2.


PMID- 21812792
OWN - NLM
STAT- MEDLINE
DCOM- 20120522
LR  - 20211020
IS  - 1467-9566 (Electronic)
IS  - 0141-9889 (Linking)
VI  - 34
IP  - 1
DP  - 2012 Jan
TI  - Embryo futures and stem cell research: the management of informed uncertainty.
PG  - 114-29
LID - 10.1111/j.1467-9566.2011.01367.x [doi]
AB  - In the social worlds of assisted conception and stem cell science, uncertainties 
      proliferate and particular framings of the future may be highly strategic. In
      this article we explore meanings and articulations of the future using data from 
      our study of ethical and social issues implicated by the donation of embryos to
      human embryonic stem cell research in three linked assisted conception units and 
      stem cell laboratories in the UK. Framings of the future in this field inform the
      professional management of uncertainty and we explore some of the tensions this
      involves in practice. The bifurcation of choices for donating embryos into
      accepting informed uncertainty or not donating at all was identified through the 
      research process of interviews and ethics discussion groups. Professional staff
      accounts in this study contained moral orientations that valued ideas such as
      engendering patient trust by offering full information, the sense of collective
      ownership of the National Heath Service and publicly funded science and ideas for
      how donors might be able to give restricted consent as a third option.
CI  - (c) 2011 The Authors. Sociology of Health & Illness (c) 2011 Foundation for the
      Sociology of Health & Illness/Blackwell Publishing Ltd.
FAU - Ehrich, Kathryn
AU  - Ehrich K
AD  - King's National Institute for Health Research Patient Safety and Service Quality 
      Research Centre, King's College London, UK. kathryn.ehrich@kcl.ac.uk
FAU - Williams, Clare
AU  - Williams C
FAU - Farsides, Bobbie
AU  - Farsides B
FAU - Scott, Rosamund
AU  - Scott R
LA  - eng
GR  - 086034/Wellcome Trust/United Kingdom
GR  - 081414/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110803
PL  - England
TA  - Sociol Health Illn
JT  - Sociology of health & illness
JID - 8205036
SB  - IM
MH  - Anthropology, Cultural
MH  - *Embryonic Stem Cells
MH  - England
MH  - *Fertilization in Vitro
MH  - Health Personnel/*ethics/psychology
MH  - Humans
MH  - Stem Cell Research/*ethics
MH  - Tissue Donors/*ethics/psychology
MH  - Uncertainty
PMC - PMC3378712
EDAT- 2011/08/05 06:00
MHDA- 2012/05/23 06:00
CRDT- 2011/08/05 06:00
PHST- 2011/08/05 06:00 [entrez]
PHST- 2011/08/05 06:00 [pubmed]
PHST- 2012/05/23 06:00 [medline]
AID - 10.1111/j.1467-9566.2011.01367.x [doi]
PST - ppublish
SO  - Sociol Health Illn. 2012 Jan;34(1):114-29. doi: 10.1111/j.1467-9566.2011.01367.x.
      Epub 2011 Aug 3.


PMID- 21812501
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20220321
IS  - 1179-1969 (Electronic)
IS  - 1170-229X (Linking)
VI  - 28
IP  - 8
DP  - 2011 Aug 1
TI  - Exclusion of older people from clinical trials: professional views from nine
      European countries participating in the PREDICT study.
PG  - 667-77
LID - 10.2165/11591990-000000000-00000 [doi]
AB  - BACKGROUND: There has been concern about under-representation of older people in 
      clinical trials. The PREDICT study reported that older people and those with
      co-morbidity continue to be excluded unjustifiably from clinical trials. However,
      there is no information about differences of opinion on these issues between EU
      countries. The results of a survey of health-related professionals from nine EU
      countries that participated in the PREDICT study are presented in this study.
      OBJECTIVE: The aim of the study was to identify and examine any differences of
      opinion between EU countries on the inclusion of older patients in clinical
      trials. METHODS: A questionnaire using a Likert scale and free text was completed
      by 521 general practitioners, geriatricians, clinical researchers, ethicists,
      nurses and industry pharmacologists/pharmacists. The questions explored the
      impact of the present situation, possible reasons for under-representation and
      potential methods of improving participation. Countries participating were the
      Czech Republic, Israel, Italy, Lithuania, the Netherlands, Poland, Romania, Spain
      and the UK. RESULTS: There was agreement that exclusion from clinical trials on
      age grounds alone was unjustified (87%) and that under-representation of older
      people in trials caused difficulties for prescribers (79%) and patients (73%).
      There were national differences between professionals. All but the Lithuanians
      believed that older people were disadvantaged because of under-representation.
      The Czech, Lithuanian and Romanian professionals felt that it was justified to
      have age limits based on co-morbidity (61-83%) and polypharmacy (63-85%).
      Romanians also thought that having age limits on trial participation was
      justified because of reduced life expectancy (62%) and physical disability (58%) 
      in older people. All but the Romanian professionals felt that the present
      arrangements for clinical trials were satisfactory (62%). All but the Israelis
      (56%) and Lithuanians (70%) agreed that regulation of clinical trials needed
      alteration. CONCLUSIONS: Although respondent selection bias cannot be excluded,
      the differences that emerged between countries may be the result of the political
      and healthcare-system differences between older and newer members of the EU.
      These differences may influence decision making about clinical trial regulations 
      and practice in older people.
FAU - Crome, Peter
AU  - Crome P
AD  - Institute for Life Course Studies, Keele University, Staffordshire, UK.
      p.crome@med.keele.ac.uk
FAU - Lally, Frank
AU  - Lally F
FAU - Cherubini, Antonio
AU  - Cherubini A
FAU - Oristrell, Joaquim
AU  - Oristrell J
FAU - Beswick, Andrew D
AU  - Beswick AD
FAU - Clarfield, A Mark
AU  - Clarfield AM
FAU - Hertogh, Cees
AU  - Hertogh C
FAU - Lesauskaite, Vita
AU  - Lesauskaite V
FAU - Prada, Gabriel I
AU  - Prada GI
FAU - Szczerbinska, Katarzyna
AU  - Szczerbinska K
FAU - Topinkova, Eva
AU  - Topinkova E
FAU - Sinclair-Cohen, Judith
AU  - Sinclair-Cohen J
FAU - Edbrooke, David
AU  - Edbrooke D
FAU - Mills, Gary
AU  - Mills G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - New Zealand
TA  - Drugs Aging
JT  - Drugs & aging
JID - 9102074
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Clinical Trials as Topic/economics/legislation &
      jurisprudence/*methods/*statistics & numerical data
MH  - Comorbidity
MH  - Epidemiologic Research Design
MH  - Europe
MH  - *Expert Testimony
MH  - Humans
MH  - *Patient Selection/ethics
MH  - Physicians
MH  - Surveys and Questionnaires
EDAT- 2011/08/05 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/08/05 06:00
PHST- 2011/08/05 06:00 [entrez]
PHST- 2011/08/05 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - 6 [pii]
AID - 10.2165/11591990-000000000-00000 [doi]
PST - ppublish
SO  - Drugs Aging. 2011 Aug 1;28(8):667-77. doi: 10.2165/11591990-000000000-00000.


PMID- 21812238
OWN - NLM
STAT- MEDLINE
DCOM- 20110809
LR  - 20110804
IS  - 0023-7205 (Print)
IS  - 0023-7205 (Linking)
VI  - 108
IP  - 21
DP  - 2011 May 25-31
TI  - [Withdrawal of life support care is an ethical decision].
PG  - 1168-9
FAU - Engstrom, Ingemar
AU  - Engstrom I
AD  - ingemar.engstrom@orebroll.se
LA  - swe
PT  - Journal Article
TT  - Att avbryta en livsuppehallande behandling ar ett etiskt beslut.
PL  - Sweden
TA  - Lakartidningen
JT  - Lakartidningen
JID - 0027707
SB  - IM
MH  - Euthanasia, Passive/*ethics
MH  - Humans
MH  - Life Support Care/*ethics
MH  - Practice Guidelines as Topic
MH  - Right to Die/ethics
MH  - Sweden
EDAT- 2011/08/05 06:00
MHDA- 2011/08/10 06:00
CRDT- 2011/08/05 06:00
PHST- 2011/08/05 06:00 [entrez]
PHST- 2011/08/05 06:00 [pubmed]
PHST- 2011/08/10 06:00 [medline]
PST - ppublish
SO  - Lakartidningen. 2011 May 25-31;108(21):1168-9.


PMID- 21811960
OWN - NLM
STAT- MEDLINE
DCOM- 20120125
LR  - 20110912
IS  - 1439-3646 (Electronic)
IS  - 0947-7349 (Linking)
VI  - 119
IP  - 8
DP  - 2011 Sep
TI  - The evidence for the use of growth factors and active skin substitutes for the
      treatment of non-infected diabetic foot ulcers (DFU): a health technology
      assessment (HTA).
PG  - 472-9
LID - 10.1055/s-0031-1279713 [doi]
AB  - AIMS: Assessment of the safety, efficacy and effectiveness of growth factors
      alone or in combination with other technologies in the treatment of DFU including
      medical, economical, social, ethical and juridical aspects. METHODS: We
      systematically searched relevant data bases limited to English and German
      language and publications since 1990. Review and assessment of the quality of
      publications followed methods conforming to widely accepted standards for
      evidence-based medicine and health economics. RESULTS: We identified 25 studies
      comparing becaplermin, rhEGF, bFGF and the metabolically active skin grafts
      Dermagraft and Apligraf with standard wound care (SWC) alone or extracellular
      wound matrix. Study duration ranged from 12 to 20 weeks and the study population 
      comprised between 17 and 382 patients. Treatment with becaplermin, rhEGF,
      Dermagraft and Apligraf resulted in a higher incidence of complete wound closure 
      and shorter time to complete wound healing with statistically significant
      differences. Regarding the proportion of adverse events there was no difference
      between treatment groups. The methodological quality of the studies was affected 
      by significant deficiencies. Economic evaluations showed becaplermin being
      cost-effective. CONCLUSIONS: Add-on therapy with growth factors and active skin
      substitutes for treating uncomplicated DFU could be an alternative to SWC alone. 
      For explicit recommendations further studies with stronger evidence are
      necessary.
CI  - (c) J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart . New York.
FAU - Buchberger, B
AU  - Buchberger B
AD  - University of Duisburg-Essen, Essen, Germany.
      barbara.buchberger@medman.uni-due.de
FAU - Follmann, M
AU  - Follmann M
FAU - Freyer, D
AU  - Freyer D
FAU - Huppertz, H
AU  - Huppertz H
FAU - Ehm, A
AU  - Ehm A
FAU - Wasem, J
AU  - Wasem J
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110802
PL  - Germany
TA  - Exp Clin Endocrinol Diabetes
JT  - Experimental and clinical endocrinology & diabetes : official journal, German
      Society of Endocrinology [and] German Diabetes Association
JID - 9505926
RN  - 0 (Platelet-Derived Growth Factor)
RN  - 0 (Recombinant Proteins)
RN  - 62031-54-3 (Fibroblast Growth Factors)
RN  - 62229-50-9 (Epidermal Growth Factor)
SB  - IM
MH  - Combined Modality Therapy
MH  - Diabetic Foot/*drug therapy/economics/*therapy
MH  - Epidermal Growth Factor/adverse effects/economics/*therapeutic use
MH  - *Evidence-Based Medicine
MH  - Fibroblast Growth Factors/adverse effects/economics/*therapeutic use
MH  - Humans
MH  - Platelet-Derived Growth Factor/adverse effects/economics/*therapeutic use
MH  - Recombinant Proteins/adverse effects/economics/therapeutic use
MH  - *Skin, Artificial/adverse effects/economics
MH  - Technology Assessment, Biomedical
EDAT- 2011/08/04 06:00
MHDA- 2012/01/26 06:00
CRDT- 2011/08/04 06:00
PHST- 2011/08/04 06:00 [entrez]
PHST- 2011/08/04 06:00 [pubmed]
PHST- 2012/01/26 06:00 [medline]
AID - 10.1055/s-0031-1279713 [doi]
PST - ppublish
SO  - Exp Clin Endocrinol Diabetes. 2011 Sep;119(8):472-9. doi: 10.1055/s-0031-1279713.
      Epub 2011 Aug 2.


PMID- 21811891
OWN - NLM
STAT- MEDLINE
DCOM- 20120217
LR  - 20211020
IS  - 1433-0385 (Electronic)
IS  - 0009-4722 (Linking)
VI  - 82
IP  - 9
DP  - 2011 Sep
TI  - [Forequarter amputation of the right upper chest: limitations of ultra radical
      interdisciplinary oncological surgery].
PG  - 834-8
LID - 10.1007/s00104-011-2136-2 [doi]
AB  - Total forearm free flap procedures after forequarter amputations have been
      sparsely described in the literature. Using the amputated arm as a "free filet
      flap" remains a viable surgical option after radical forequarter amputations
      performed for the resection of large, invasive tumors of the shoulder or thoracic
      wall region. Using the forequarter specimen as a donor site seems favorable in
      that it eliminates the usual donor site morbidity. Nevertheless, in our patient
      with invasive ductal carcinoma of the breast and a fibrosarcoma suffering from
      severe pain and septic conditions - which failed to respond properly to
      conservative therapy - as well as rapidly progressive tumor ulceration despite
      repeated radiation therapy, we decided to attempt complete tumor removal by
      hemithoracectomy as a last resort. This decision was taken following multiple
      interdisciplinary consultations and thorough patient information. Although
      technically feasible with complete tumor removal and safe soft tissue free flap
      coverage, the postoperative course raises questions about the advisability of
      such ultra radical surgical procedures, as well as about the limitations of
      respiratory recovery after hemithoracectomy with removal of the sternum. Hence,
      based on our experience with such radical tumor surgery, we discuss the issues of
      diminished postoperative pulmonary function, intensive care possibilities and
      ethical issues. The English full-text version of this article is available at
      SpringerLink (under "Supplemental").
FAU - Dragu, A
AU  - Dragu A
AD  - Klinik fur Plastische und Handchirurgie, Universitatsklinikum,
      Friedrich-Alexander-Universitat Erlangen-Nurnberg, Deutschland.
      adrian.dragu@uk-erlangen.de
FAU - Hohenberger, W
AU  - Hohenberger W
FAU - Lang, W
AU  - Lang W
FAU - Schmidt, J
AU  - Schmidt J
FAU - Horch, R E
AU  - Horch RE
LA  - ger
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - "Forequarter-Amputation" des rechten oberen Rumpfs : Grenzen der ultraradikalen
      interdisziplinaren Tumorchirurgie.
PL  - Germany
TA  - Chirurg
JT  - Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
JID - 16140410R
SB  - IM
MH  - Amputation/*methods
MH  - Blood Loss, Surgical/physiopathology
MH  - Brachial Plexus/pathology/surgery
MH  - Breast Neoplasms/pathology/*surgery
MH  - Carcinoma, Ductal/pathology/*surgery
MH  - Chemoradiotherapy, Adjuvant
MH  - Combined Modality Therapy
MH  - *Cooperative Behavior
MH  - Fatal Outcome
MH  - Female
MH  - Fibrosarcoma/pathology/*surgery
MH  - Free Tissue Flaps/*blood supply
MH  - Humans
MH  - *Interdisciplinary Communication
MH  - Lymphatic Metastasis/pathology
MH  - Microsurgery/methods
MH  - Middle Aged
MH  - Multiple Organ Failure/etiology/therapy
MH  - Neoplasm Invasiveness
MH  - Neoplasm Staging
MH  - Neoplasms, Second Primary/pathology/*surgery
MH  - *Patient Care Team
MH  - Postoperative Complications/*etiology/therapy
MH  - Sternum/*surgery
MH  - Surgical Flaps
MH  - Surgical Mesh
MH  - Thoracic Neoplasms/pathology/*surgery
MH  - Thoracic Wall/*surgery
EDAT- 2011/08/04 06:00
MHDA- 2012/02/18 06:00
CRDT- 2011/08/04 06:00
PHST- 2011/08/04 06:00 [entrez]
PHST- 2011/08/04 06:00 [pubmed]
PHST- 2012/02/18 06:00 [medline]
AID - 10.1007/s00104-011-2136-2 [doi]
PST - ppublish
SO  - Chirurg. 2011 Sep;82(9):834-8. doi: 10.1007/s00104-011-2136-2.


PMID- 21811881
OWN - NLM
STAT- MEDLINE
DCOM- 20120124
LR  - 20211020
IS  - 1573-6571 (Electronic)
IS  - 0022-4197 (Linking)
VI  - 50
IP  - 3
DP  - 2011 Sep
TI  - Enacting remembrance: turning toward memorializing September 11th.
PG  - 499-515
LID - 10.1007/s10943-011-9517-1 [doi]
AB  - The memorial at the site of the former World Trade Center will open on the tenth 
      anniversary of 9/11 to help us commemorate, honor, educate, and mourn.
      Memorializing is an act that involves shared memory and collective
      grieving-aiming also to restore severed communal bonds and dismantled cultural
      ideals. As such, it is a form of cultural renewal that can transform traumatized 
      mourners into an ethical community of memory. The active rituals of memorial
      activity utilize both inscribed and non-inscribed practices to help survivors of 
      mass trauma manage fear, disorganization, and helplessness as well as sorrow. To 
      bear witness to horrific events and the suffering they induced is a moral act. To
      do so together with people who may have seen the events of 9/11 from other
      perspectives, while also remembering one's own vision of what mattered, may mean 
      learning to tolerate multiple conflicting narratives about the events' meanings. 
      It is time to turn our attention from the memorial to memorializing.
FAU - Pivnick, Billie A
AU  - Pivnick BA
AD  - Department of Clinical and Counseling Psychology, Columbia University Teachers
      College, New York, NY, USA. bap50@tc.columbia.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Relig Health
JT  - Journal of religion and health
JID - 2985199R
SB  - IM
MH  - Anniversaries and Special Events
MH  - Grief
MH  - Humans
MH  - Mass Casualty Incidents
MH  - *Memory
MH  - New York City
MH  - *September 11 Terrorist Attacks
MH  - Survivors/*psychology
EDAT- 2011/08/04 06:00
MHDA- 2012/01/25 06:00
CRDT- 2011/08/04 06:00
PHST- 2011/08/04 06:00 [entrez]
PHST- 2011/08/04 06:00 [pubmed]
PHST- 2012/01/25 06:00 [medline]
AID - 10.1007/s10943-011-9517-1 [doi]
PST - ppublish
SO  - J Relig Health. 2011 Sep;50(3):499-515. doi: 10.1007/s10943-011-9517-1.


PMID- 21811369
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1998-3735 (Electronic)
IS  - 0973-1075 (Linking)
VI  - 17
IP  - Suppl
DP  - 2011 Jan
TI  - Spirituality and palliative care.
PG  - S39-41
LID - 10.4103/0973-1075.76241 [doi]
AB  - This paper shows how palliative care developed as a reaction to the
      compartimentalized technical approach of modern medicine. But what does it mean
      if we say palliative care wants to treat patients as whole persons? A few
      pitfalls need to avoided. All disciplines involved in palliative care should act 
      within the limits of their own specific professional role. Physicians and nurses 
      should certainly not force patients into spiritual or religious discussions or
      practices. They should understand that religion and spirituality also influence
      the ethical (and thus medical) choices people make, respect their own conscience 
      and worldview too and cultivate conscious compassion.
FAU - Broeckaert, Bert
AU  - Broeckaert B
AD  - Interdisciplinary Centre for the Study of Religion and Worldview, K.U. Leuven,
      Leuven, Belgium.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Indian J Palliat Care
JT  - Indian journal of palliative care
JID - 101261221
PMC - PMC3140090
OTO - NOTNLM
OT  - Ethics
OT  - Palliative care
OT  - Religion
OT  - Spirituality
EDAT- 2011/08/04 06:00
MHDA- 2011/08/04 06:01
CRDT- 2011/08/04 06:00
PHST- 2011/08/04 06:00 [entrez]
PHST- 2011/08/04 06:00 [pubmed]
PHST- 2011/08/04 06:01 [medline]
AID - 10.4103/0973-1075.76241 [doi]
AID - IJPC-17-39 [pii]
PST - ppublish
SO  - Indian J Palliat Care. 2011 Jan;17(Suppl):S39-41. doi: 10.4103/0973-1075.76241.


PMID- 21811367
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1998-3735 (Electronic)
IS  - 0973-1075 (Linking)
VI  - 17
IP  - Suppl
DP  - 2011 Jan
TI  - Networking and training in palliative care: challenging values and changing
      practice.
PG  - S33-5
LID - 10.4103/0973-1075.76239 [doi]
AB  - What make a good doctor is a question posed by the public and profession and is
      key when designing training programmes. The goal of training is to change
      practice not simply acquire knowledge yet too often curriculums and assessment
      focuses on knowledge and skills. Professional practice is underpinned by beliefs 
      and values and therefore training may need to challenge deeply held values in
      order to result in a change in practice. Palliative care offers an opportunity to
      challenge values at a deeply personal level as it brings experiences of pain and 
      suffering alongside clinical knowledge and skills. Palliative care is holistic
      and so real scenarios where physical, psychological, social and spiritual issues 
      are evident can be presented in an interactive, learner centered environment.
      Training in ethics alongside clinical skills will assist the development of
      judgment which should also be assessed. Communication skills enable the clinician
      to hear and understand the needs and wishes of those facing life limiting
      illness. Training should include aspects of modeling and mentorship to
      demonstrate and integrate the learning with the realities of clinical practice
      and include those who lead and influence policy and advocacy.
FAU - Leng, Mhoira Ef
AU  - Leng ME
AD  - Makerere University, Kampala; Medical Director Cairdeas International Palliative 
      Care Trust, United Kingdom.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Indian J Palliat Care
JT  - Indian journal of palliative care
JID - 101261221
PMC - PMC3140095
OTO - NOTNLM
OT  - Palliative care
OT  - Professional practice
OT  - Training
OT  - values
EDAT- 2011/08/04 06:00
MHDA- 2011/08/04 06:01
CRDT- 2011/08/04 06:00
PHST- 2011/08/04 06:00 [entrez]
PHST- 2011/08/04 06:00 [pubmed]
PHST- 2011/08/04 06:01 [medline]
AID - 10.4103/0973-1075.76239 [doi]
AID - IJPC-17-33 [pii]
PST - ppublish
SO  - Indian J Palliat Care. 2011 Jan;17(Suppl):S33-5. doi: 10.4103/0973-1075.76239.


PMID- 21810938
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20161021
IS  - 1758-1125 (Electronic)
IS  - 0268-3555 (Linking)
VI  - 26
IP  - 7
DP  - 2011 Oct
TI  - Tumescent anaesthesia in combination with femoral nerve block for surgery of
      varicose veins: prilocaine 0.1% versus 0.2%.
PG  - 292-7
LID - 10.1258/phleb.2010.010038 [doi]
AB  - OBJECTIVE: Results of a prospective, randomized, double-blinded study about
      tumescent anaesthesia (TA) in combination with femoral nerve block (FNB) for
      surgery of varicose veins are reported. The aim is to compare two different
      concentrations of prilocaine in TA. METHOD: With approval of the ethical
      committee and informed consent, FNB (nerve stimulation, 20 mL prilocaine 0.75%)
      was performed followed by TA using prilocaine 0.1% versus 0.2% (groups P0.1 and
      P0.2). Further medication was standardized. Overall amount of prilocaine was
      recorded, plasma levels of 20 patients measured regularly. Side-effects, patient 
      satisfaction and pain scores were compared (P < 0.05). RESULTS: Ninety patients
      were included. In one patient (P0.1), general anaesthesia was necessary. There
      was no difference in pain scores, need for rescue medication or patient
      satisfaction. More prilocaine was administered in P0.2 (P < 0.0001) with higher
      but far below toxic plasma levels. In three patients (P0.2) mild
      met-haemoglobinaemia was confirmed. CONCLUSION: TA with prilocaine 0.1% in
      combination with FNB is sufficient to provide high patient satisfaction during
      varicosis surgery.
FAU - Hillermann, T
AU  - Hillermann T
AD  - Department of Anaesthesia, Venenklinik, Kreuzlingen, Switzerland.
      hillerbrueggen@bluewin.ch
FAU - Dullenkopf, A
AU  - Dullenkopf A
FAU - Joechle, W
AU  - Joechle W
FAU - Traber, J
AU  - Traber J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110802
PL  - England
TA  - Phlebology
JT  - Phlebology
JID - 9012921
RN  - 0 (Anesthetics, Local)
RN  - 046O35D44R (Prilocaine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anesthetics, Local/*administration & dosage/adverse effects/pharmacokinetics
MH  - Double-Blind Method
MH  - Female
MH  - *Femoral Nerve
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Block/*methods
MH  - Prilocaine/*administration & dosage/adverse effects/pharmacokinetics
MH  - Prospective Studies
MH  - Varicose Veins/*surgery
EDAT- 2011/08/04 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/08/04 06:00
PHST- 2011/08/04 06:00 [entrez]
PHST- 2011/08/04 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - phleb.2010.010038 [pii]
AID - 10.1258/phleb.2010.010038 [doi]
PST - ppublish
SO  - Phlebology. 2011 Oct;26(7):292-7. doi: 10.1258/phleb.2010.010038. Epub 2011 Aug
      2.


PMID- 21810923
OWN - NLM
STAT- MEDLINE
DCOM- 20120312
LR  - 20150813
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 12
DP  - 2011 Dec
TI  - Death and legal fictions.
PG  - 719-22
LID - 10.1136/jme.2011.045385 [doi]
AB  - Advances in life-saving technologies in the past few decades have challenged our 
      traditional understandings of death. Traditionally, death was understood to occur
      when a person stops breathing, their heart stops beating and they are cold to the
      touch. Today, physicians determine death by relying on a diagnosis of 'total
      brain failure' or by waiting a short while after circulation stops. Evidence has 
      emerged, however, that the conceptual bases for these approaches to determining
      death are fundamentally flawed and depart substantially from the established
      biological conception of death. We argue that the current approach to determining
      death consists of two different types of unacknowledged legal fictions. These
      legal fictions were developed for practices that are largely ethically legitimate
      but need to be reconciled with the law. The considerable debate over the
      determination of death in the medical and scientific literature has not informed 
      the public that vital organs are being procured from still-living donors and it
      seems unlikely that this information can remain hidden for long. Given the
      instability of the status quo and the difficulty of making the substantial legal 
      changes required by complete transparency, we argue for a second-best policy
      solution: acknowledging the legal fictions involved in determining death to move 
      in the direction of greater transparency. This may someday result in more
      substantial legal change to directly confront the challenges raised by
      life-sustaining and life-preserving technologies without the need for fictions.
FAU - Shah, Seema K
AU  - Shah SK
AD  - Department of Bioethics, Division of AIDS, National Institutes of Health, NIH
      Clinical Center, Building 10, Room 1C118, Bethesda, MD 20892, USA.
      shahse@mail.nih.gov
FAU - Truog, Robert D
AU  - Truog RD
FAU - Miller, Franklin G
AU  - Miller FG
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
DEP - 20110802
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Bioethical Issues
MH  - Brain Death/*diagnosis/*legislation & jurisprudence
MH  - Death
MH  - Ethics, Clinical
MH  - *Ethics, Medical
MH  - Humans
MH  - Morals
MH  - Tissue Donors/legislation & jurisprudence
MH  - Tissue and Organ Procurement/legislation & jurisprudence
EDAT- 2011/08/04 06:00
MHDA- 2012/03/13 06:00
CRDT- 2011/08/04 06:00
PHST- 2011/08/04 06:00 [entrez]
PHST- 2011/08/04 06:00 [pubmed]
PHST- 2012/03/13 06:00 [medline]
AID - jme.2011.045385 [pii]
AID - 10.1136/jme.2011.045385 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Dec;37(12):719-22. doi: 10.1136/jme.2011.045385. Epub 2011 Aug
      2.


PMID- 21810854
OWN - NLM
STAT- MEDLINE
DCOM- 20120112
LR  - 20181201
IS  - 1758-1087 (Electronic)
IS  - 0967-7720 (Linking)
VI  - 19
IP  - 3
DP  - 2011 Aug
TI  - Quest for professionalism: a biography of the North American Medical and Surgical
      Journal (1826-31).
PG  - 132-7
LID - 10.1258/jmb.2010.010056 [doi]
AB  - This is the biography of a deceased medical journal, the North American Medical
      and Surgical Journal, born in 1826 in Philadelphia. It was a publication of the
      Philadelphia Chapter of the Kappa Lambda Society. In the prospectus of the North 
      American Medical and Surgical Journal the promoters observed that a
      well-conducted journal would achieve the object of elevating the medical
      profession to its legitimate rank which up to that time had been the recipient of
      low public opinion. The Journal hoped to inculcate 'a higher standard of
      excellence not merely in the professional or ministrative but also in the ethical
      relations and duties of physicians'. After several successful and productive
      years it passed into history in October 1831, the victim of financial difficulty.
FAU - Shultz, S M
AU  - Shultz SM
AD  - Philip A Hoover MD Library, Wellspan Health at York Hospital, 1001 South George
      Street, York, PA 17405, USA. sshultz@wellspan.org
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Portrait
PL  - England
TA  - J Med Biogr
JT  - Journal of medical biography
JID - 9308895
SB  - IM
MH  - General Surgery/*history
MH  - History, 19th Century
MH  - Humans
MH  - Journalism, Medical/*history
MH  - North America
MH  - Periodicals as Topic/*history
MH  - Professional Role/*history
MH  - Publishing/*history
MH  - Social Identification
MH  - Staff Development/*history
EDAT- 2011/08/04 06:00
MHDA- 2012/01/13 06:00
CRDT- 2011/08/04 06:00
PHST- 2011/08/04 06:00 [entrez]
PHST- 2011/08/04 06:00 [pubmed]
PHST- 2012/01/13 06:00 [medline]
AID - 19/3/132 [pii]
AID - 10.1258/jmb.2010.010056 [doi]
PST - ppublish
SO  - J Med Biogr. 2011 Aug;19(3):132-7. doi: 10.1258/jmb.2010.010056.


PMID- 21810168
OWN - NLM
STAT- MEDLINE
DCOM- 20120621
LR  - 20110914
IS  - 1526-4637 (Electronic)
IS  - 1526-2375 (Linking)
VI  - 12
IP  - 9
DP  - 2011 Sep
TI  - Defining chronic pain ethics.
PG  - 1376-84
LID - 10.1111/j.1526-4637.2011.01192.x [doi]
AB  - OBJECTIVE: To identify current issues in the diagnosis and treatment of chronic
      pain. DESIGN: Focus groups were convened to discuss the current issues in chronic
      pain care. Commentary was analyzed across focus groups using an interpretivist
      method of qualitative data analysis. Setting. Focus groups were held in five
      major US cities throughout the United States. PARTICIPANTS: Key stakeholders
      working and thinking about the issues surrounding chronic pain, including people 
      with pain, providers, insurance and pharmaceutical industry representatives, law 
      enforcement agents, and advocacy groups. OUTCOME MEASURES: Qualitative data was
      analyzed to determine if consensus regarding the current issues in the diagnosis 
      and treatment of chronic pain exist. RESULTS: Six major themes emerged regarding 
      chronic pain, all of which contained an ethical component: 1) reducing
      disparities in access to pain care among the young, elderly, and lower
      socioeconomic groups, 2) defining quality of care in pain management, 3) the need
      to train qualified providers and training programs in pain medicine, 4) the need 
      for evidence-based public policy regarding opioid use and diversion, 5) the need 
      to raise awareness about chronic pain as a disease to prevent stigmatization and 
      discrimination, and 6) promotion of multimodal therapies for pain care as a way
      of diverting attention from opioid abuse problem. CONCLUSIONS: There is
      nationwide consensus among those holding a stake in the diagnosis and treatment
      of chronic pain regarding the ethical issues that must be addressed. Raising
      awareness about chronic pain, improving access and outcomes to quality pain care,
      and resolving public policy debates about the use of opioids in chronic pain
      populations are the first steps to ensuring a morally justifiable approach to
      chronic pain management in the 21st century.
CI  - Wiley Periodicals, Inc.
FAU - McGee, Summer J
AU  - McGee SJ
AD  - Health Policy and Management, Unversity of Kansas Medical Center and the Center
      for Practical Bioethics, 1111 Main Street, Harzfeld Building Suite 500, Kansas
      City, MO 64105, USA. smcgee@practicalbioethics.org
FAU - Kaylor, Brett D
AU  - Kaylor BD
FAU - Emmott, Helen
AU  - Emmott H
FAU - Christopher, Myra J
AU  - Christopher MJ
LA  - eng
PT  - Consensus Development Conference
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110802
PL  - England
TA  - Pain Med
JT  - Pain medicine (Malden, Mass.)
JID - 100894201
SB  - IM
CIN - Pain Med. 2011 Sep;12(9):1295-6. PMID: 21914114
MH  - Chronic Pain/diagnosis/*therapy
MH  - Education, Medical, Continuing/ethics/standards
MH  - Evidence-Based Medicine/*ethics/standards
MH  - Focus Groups/standards
MH  - Health Services Accessibility/*ethics/standards
MH  - Humans
MH  - Quality Assurance, Health Care/*ethics/methods/standards
EDAT- 2011/08/04 06:00
MHDA- 2012/06/22 06:00
CRDT- 2011/08/04 06:00
PHST- 2011/08/04 06:00 [entrez]
PHST- 2011/08/04 06:00 [pubmed]
PHST- 2012/06/22 06:00 [medline]
AID - 10.1111/j.1526-4637.2011.01192.x [doi]
PST - ppublish
SO  - Pain Med. 2011 Sep;12(9):1376-84. doi: 10.1111/j.1526-4637.2011.01192.x. Epub
      2011 Aug 2.


PMID- 21810007
OWN - NLM
STAT- MEDLINE
DCOM- 20120111
LR  - 20181201
IS  - 1536-0539 (Electronic)
IS  - 1536-0288 (Linking)
VI  - 25
IP  - 3
DP  - 2011
TI  - Ethical considerations in urine drug testing.
PG  - 265-6
LID - 10.3109/15360288.2011.599486 [doi]
AB  - Recent passage of a House Bill in the state of Washington led to a commentary on 
      whether mandates for urine drug testing of pain patients represented a breach of 
      the Fourth and Fourteenth Amendment rights of patients. Issues over true consent 
      to such tests and potential view of warrantless searches were discussed. The
      authors address these concerns in a broader context of risk management and
      stratification efforts, along with discussion about the need for a tailored
      approach in this arena and consideration of cost burden for such tests. Finally, 
      the argument is made that social justice issues need to be considered (along with
      issues of autonomy, beneficence, and nonmaleficence).
FAU - Passik, Steven D
AU  - Passik SD
AD  - Psychosomatic Medicine, Vanderbilt University Medical Center, Nashville,
      Tennessee, USA.
FAU - Kirsh, Kenneth L
AU  - Kirsh KL
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20110802
PL  - England
TA  - J Pain Palliat Care Pharmacother
JT  - Journal of pain & palliative care pharmacotherapy
JID - 101125608
RN  - 0 (Analgesics, Opioid)
SB  - IM
CON - J Pain Palliat Care Pharmacother. 2011;25(1):42-8. PMID: 21426217
MH  - Analgesics, Opioid/*therapeutic use
MH  - Humans
MH  - Opioid-Related Disorders/*diagnosis
MH  - Pain/*drug therapy
MH  - Substance Abuse Detection/*legislation & jurisprudence
EDAT- 2011/08/04 06:00
MHDA- 2012/01/12 06:00
CRDT- 2011/08/04 06:00
PHST- 2011/08/04 06:00 [entrez]
PHST- 2011/08/04 06:00 [pubmed]
PHST- 2012/01/12 06:00 [medline]
AID - 10.3109/15360288.2011.599486 [doi]
PST - ppublish
SO  - J Pain Palliat Care Pharmacother. 2011;25(3):265-6. doi:
      10.3109/15360288.2011.599486. Epub 2011 Aug 2.


PMID- 21809763
OWN - NLM
STAT- MEDLINE
DCOM- 20120329
LR  - 20190923
IS  - 0253-1933 (Print)
IS  - 0253-1933 (Linking)
VI  - 30
IP  - 1
DP  - 2011 Apr
TI  - Embryo transfer: a comparative biosecurity advantage in international movements
      of germplasm.
PG  - 177-88
AB  - This paper uses cattle as a model to provide an overview of the hazards involved 
      in the transfer of in vivo-derived and in vitro-produced embryos. While
      scientific studies in recent decades have led to the identification of pathogens 
      that may be associated with both in vivo- and in vitro-derived embryos, those
      studies have also been the basis of appropriate disease control measures to
      reduce the risks to a negligible level. These disease control measures have been 
      identified and assessed by the International Embryo Transfer Society's (lETS)
      Health and Safety Advisory Committee, the expert body that advises the World
      Organisation for Animal Health (OIE) on matters related to the safety of embryo
      transfer. Through the OIE's processes for developing and adopting international
      standards, the disease control measures identified by the IETS have been
      incorporated into the Terrestrial Animal Health Code. The basic principles rely
      on the crucial ethical roles of the embryo collection team and embryo transfer
      team, under the leadership of approved veterinarians. Decades of experience, with
      nearly 10 million embryos transferred, have demonstrated the very significant
      biosecurity advantage that embryo transfer technology has when moving germplasm
      internationally, provided that the international standards developed by the IETS 
      and adopted by the OIE are strictly followed.
FAU - Thibier, M
AU  - Thibier M
AD  - Saint Sauveur, 64120 Saint Palais, France.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - France
TA  - Rev Sci Tech
JT  - Revue scientifique et technique (International Office of Epizootics)
JID - 8712301
SB  - IM
MH  - Animals
MH  - Cattle/*embryology
MH  - Cattle Diseases/embryology/*prevention & control/transmission
MH  - Commerce/economics/*standards
MH  - *Embryo Transfer/adverse effects/standards
MH  - *Internationality
MH  - Risk Management/methods/standards
EDAT- 2011/08/04 06:00
MHDA- 2012/03/30 06:00
CRDT- 2011/08/04 06:00
PHST- 2011/08/04 06:00 [entrez]
PHST- 2011/08/04 06:00 [pubmed]
PHST- 2012/03/30 06:00 [medline]
AID - 10.20506/rst.30.1.2024 [doi]
PST - ppublish
SO  - Rev Sci Tech. 2011 Apr;30(1):177-88. doi: 10.20506/rst.30.1.2024.


PMID- 21778781
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20110722
IS  - 1423-0267 (Electronic)
IS  - 0030-3755 (Linking)
VI  - 226 Suppl 1
DP  - 2011
TI  - The use of continuous silicone oil infusion as a peroperative tool to facilitate 
      break localisation, vitreous base dissection and drainage of subretinal fluid.
PG  - 53-7
LID - 10.1159/000328213 [doi]
AB  - INTRODUCTION: We introduce the use of low-molecular-weight silicone oil as an
      infusion and as a peroperative tool to facilitate three specific surgical steps, 
      namely internal search for retinal breaks, vitreous base shaving and drainage of 
      subretinal fluid. METHOD AND PATIENTS: Ethics committee approval was obtained to 
      test this novel agent in a small number of cases as a pilot study. Following
      vitrectomy the posterior retina was reattached and stabilised using
      perfluorocarbon liquid (PFCL). The infusion of balanced salt solution was then
      stopped and replaced with 5 mPas silicone oil. Subsequent surgery was assessed as
      to whether the infusion was helpful in the three surgical steps. Five cases were 
      selected for this pilot study. Three presented with long-standing rhegmatogenous 
      retinal detachment (RRD) of 2 or more months: 1 had dense vitreous haemorrhage
      and no fundal view at presentation; 2 had proliferative vitreoretinopathy. Of the
      remaining 2 cases, 1 had a giant retinal break and the other case had a combined 
      diabetic tractional retinal detachment and RRD. RESULTS: Additional retinal
      breaks were found in 2 patients. The silicone oil joined with the PFCL to form a 
      single bubble. The vitreous base along with the operculum of any retinal break
      was reflected anteriorly. The infusion of oil stabilised the anterior retina,
      making it possible to shave the vitreous closely in all 5 patients. Visualisation
      of the vitreous gel was also improved. There was a clear interface between
      vitreous and oil because of the large difference between the refractive indices
      of vitreous and oil. Four of the 5 patients had a total reattachment with one
      procedure. In the 2 cases in which 5,000 mPas silicone oil was used for long-term
      postoperative tamponade, no emulsification was observed. Follow-up of patients
      ranged from 6 to 13 months. There were no additional serious adverse reactions
      recorded. CONCLUSION: We found that the experience of using silicone oil was very
      highly positive.
CI  - Copyright (c) 2011 S. Karger AG, Basel.
FAU - Wong, David
AU  - Wong D
AD  - Eye Institute, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, SAR, 
      China. shdwong @ hku.hk
FAU - Lai, Wico
AU  - Lai W
FAU - Yusof, Wadid
AU  - Yusof W
LA  - eng
PT  - Journal Article
DEP - 20110722
PL  - Switzerland
TA  - Ophthalmologica
JT  - Ophthalmologica. Journal international d'ophtalmologie. International journal of 
      ophthalmology. Zeitschrift fur Augenheilkunde
JID - 0054655
RN  - 0 (Silicone Oils)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Drainage/*methods
MH  - Female
MH  - Humans
MH  - Intraoperative Care
MH  - Laser Therapy
MH  - Male
MH  - Middle Aged
MH  - Molecular Weight
MH  - Phacoemulsification
MH  - Pilot Projects
MH  - Retinal Detachment/*surgery
MH  - Retinal Perforations/*diagnosis
MH  - Silicone Oils/*administration & dosage/chemistry
MH  - Subretinal Fluid
MH  - Vitrectomy
MH  - Vitreous Body/*surgery
EDAT- 2011/08/04 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/07/23 06:00
PHST- 2011/07/23 06:00 [entrez]
PHST- 2011/08/04 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - 000328213 [pii]
AID - 10.1159/000328213 [doi]
PST - ppublish
SO  - Ophthalmologica. 2011;226 Suppl 1:53-7. doi: 10.1159/000328213. Epub 2011 Jul 22.


PMID- 21809408
OWN - NLM
STAT- MEDLINE
DCOM- 20120213
LR  - 20131121
IS  - 1099-1557 (Electronic)
IS  - 1053-8569 (Linking)
VI  - 20
IP  - 10
DP  - 2011 Oct
TI  - Medicine safety: experiences and perceptions of the general public in Liverpool.
PG  - 1098-103
LID - 10.1002/pds.2178 [doi]
AB  - PURPOSE: To determine whether views of medicine safety, awareness of medicines'
      side effects and reporting behaviours were related to experiences of suspected
      side effects among the general public. METHOD: Street interviews with the general
      public in central Liverpool, using closed and open questions. University ethics
      approval was obtained. RESULTS: A total of 436 people were interviewed, most
      (313; 71.8%) of whom obtained a medicine at least once every 3 months, 153
      (37.4%) only prescribed medicines, 73 (16.7%) only over-the-counter (OTC)
      medicines and 87 (19.9%) both. A total of 198 (45.4%) respondents claimed to have
      experienced a side effect from a prescription medicine, an OTC medicine or both, 
      and 110 (25.2%) knew someone who had experienced a side effect. Experiences of
      suspected adverse drug reactions (ADRs) did not appear to influence perceptions
      of medicine safety, with most feeling that both prescribed and OTC medicines were
      safe. Only 94 (21.6%) respondents identified the Medicines and Healthcare
      Products Regulatory Agency as being responsible for monitoring medicine safety,
      and only 27 (6.2%) were aware of direct patient reporting. Once informed about
      direct reporting, over half said that they were strongly likely to report in the 
      future, with the main reasons (272) for reporting being an ADR which was serious,
      caused hospital admission or affected daily life. CONCLUSION: Public
      understanding of medicine safety, how safety is monitored and how to report
      suspected ADRs is generally limited despite ADRs being commonly experienced. If
      awareness of direct patient reporting can be increased, the public appear to be
      willing to report and to be appropriately selective in reporting.
CI  - Copyright (c) 2011 John Wiley & Sons, Ltd.
FAU - Krska, Janet
AU  - Krska J
AD  - School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University,
      Liverpool, UK. j.krska@ljmu.ac.uk
FAU - Jones, Laura
AU  - Jones L
FAU - McKinney, Jonathan
AU  - McKinney J
FAU - Wilson, Craig
AU  - Wilson C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110802
PL  - England
TA  - Pharmacoepidemiol Drug Saf
JT  - Pharmacoepidemiology and drug safety
JID - 9208369
RN  - 0 (Nonprescription Drugs)
RN  - 0 (Prescription Drugs)
SB  - IM
MH  - Adult
MH  - *Adverse Drug Reaction Reporting Systems
MH  - Aged
MH  - Aged, 80 and over
MH  - Drug-Related Side Effects and Adverse Reactions/*epidemiology/psychology
MH  - England
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Interview, Psychological
MH  - Male
MH  - Middle Aged
MH  - Nonprescription Drugs
MH  - Prescription Drugs/*adverse effects
MH  - *Public Opinion
EDAT- 2011/08/03 06:00
MHDA- 2012/02/14 06:00
CRDT- 2011/08/03 06:00
PHST- 2011/02/07 00:00 [received]
PHST- 2011/04/26 00:00 [revised]
PHST- 2011/05/03 00:00 [accepted]
PHST- 2011/08/03 06:00 [entrez]
PHST- 2011/08/03 06:00 [pubmed]
PHST- 2012/02/14 06:00 [medline]
AID - 10.1002/pds.2178 [doi]
PST - ppublish
SO  - Pharmacoepidemiol Drug Saf. 2011 Oct;20(10):1098-103. doi: 10.1002/pds.2178. Epub
      2011 Aug 2.


PMID- 21809295
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20110802
IS  - 0047-262X (Print)
VI  - 58
IP  - 4
DP  - 2011 Aug
TI  - [The decision making process of ESRD families during the dialysis withdrawal
      period].
PG  - 106-11
AB  - Hemodialysis is a financial burden to the state and families and the cause of
      much suffering in patients. It is a life prolonging therapy and death-delaying
      treatment. When the burdens of therapy substantially outweigh its benefits,
      withdrawal from dialysis is an appropriate option. However, considering the
      ethical and legal concerns of doing such is something families must face. There
      has been little research and little understanding of the process of
      decision-making within families in Taiwan. The process is full of conflicts,
      worries, guilt, shame, and lack of consensus. Effective communication with the
      medical team to resolve the conflict and describe the prognosis is necessary in
      order to reach a consensus and move toward palliative care. The article uses a
      case report and discusses the process. Finally, the author suggests an approach
      to making the situation better in the future.
FAU - Lin, Tsai-Rung
AU  - Lin TR
AD  - Surgical Intensive Care Unit, Kaohsiung Medical University Chung-Ho Memorial
      Hospital, ROC. arainings@yahoo.com.tw
LA  - chi
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
PL  - China (Republic : 1949- )
TA  - Hu Li Za Zhi
JT  - Hu li za zhi The journal of nursing
JID - 0073267
SB  - IM
MH  - Decision Making
MH  - Humans
MH  - Infant
MH  - Kidney Failure, Chronic/*therapy
MH  - Middle Aged
MH  - *Renal Dialysis
MH  - *Withholding Treatment
EDAT- 2011/08/03 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/08/03 06:00
PHST- 2011/08/03 06:00 [entrez]
PHST- 2011/08/03 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
PST - ppublish
SO  - Hu Li Za Zhi. 2011 Aug;58(4):106-11.


PMID- 21808893
OWN - NLM
STAT- MEDLINE
DCOM- 20111206
LR  - 20190907
IS  - 1678-4561 (Electronic)
IS  - 1413-8123 (Linking)
VI  - 16
IP  - 7
DP  - 2011 Jul
TI  - [Promotion of Mental Health - Technologies for Care: emotional involvement,
      rteception, co-responsibility and autonomy].
PG  - 3051-60
LID - S1413-81232011000800005 [pii]
AB  - Healthcare relations serve as efficient devices for the promotion of mental
      health and the development of comprehensive practices. This study seeks to
      analyze the measures that make mental healthcare possible in the daily operations
      of a Psychosocial Healthcare Center (CAPS). It is qualitative research adopting a
      critical and reflexive approach conducted in CAPS in the municipality of Sobral
      in the State of Ceara. Complying with regulations, the study was submitted for
      analysis by the Committee for Ethics in Research adhering to norms for research
      involving human beings. For data gathering, conducted between May and July 2008, 
      semi-structured and systematic observation interview techniques were used. The
      research subjects involved 20 people, distributed into three groups: group I
      (mental health workers-8); group II (users-7) and group III (relatives of
      users-5). The material was organized and analyzed using principles of critical
      hermeneutics. According to the results, in the daily operations of CAPS, the
      relations of care and its devices (reception, emotional involvement,
      co-responsibility and autonomy) make the transversal adaptation of psychosocial
      practices possible. The dialogues were derived from meetings of mental health
      workers, users and relatives in their quest for healthcare solutions.
FAU - Jorge, Maria Salete Bessa
AU  - Jorge MS
AD  - Programa de Pos-Graduacao em Saude Coletiva, Centro de Ciencias da Saude,
      Universidade Estadual do Ceara, Fortaleza, Brazil. masabejo@bol.com.br
FAU - Pinto, Diego Muniz
AU  - Pinto DM
FAU - Quindere, Paulo Henrique Dias
AU  - Quindere PH
FAU - Pinto, Antonio Germane Alves
AU  - Pinto AG
FAU - Sousa, Fernando Sergio Pereira de
AU  - Sousa FS
FAU - Cavalcante, Cinthia Mendonca
AU  - Cavalcante CM
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Promocao da Saude Mental - Tecnologias do Cuidado: vinculo, acolhimento,
      co-responsabilizacao e autonomia.
PL  - Brazil
TA  - Cien Saude Colet
JT  - Ciencia & saude coletiva
JID - 9713483
SB  - IM
MH  - *Biomedical Technology
MH  - Emotions
MH  - *Health Promotion
MH  - Humans
MH  - *Mental Health
MH  - *Mental Health Services
MH  - Personal Autonomy
MH  - Social Behavior
MH  - Social Responsibility
EDAT- 2011/08/03 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/08/03 06:00
PHST- 2009/05/24 00:00 [received]
PHST- 2009/07/27 00:00 [accepted]
PHST- 2011/08/03 06:00 [entrez]
PHST- 2011/08/03 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S1413-81232011000800005 [pii]
AID - 10.1590/s1413-81232011000800005 [doi]
PST - ppublish
SO  - Cien Saude Colet. 2011 Jul;16(7):3051-60. doi: 10.1590/s1413-81232011000800005.


PMID- 21808831
OWN - NLM
STAT- MEDLINE
DCOM- 20120223
LR  - 20190606
IS  - 1518-8787 (Electronic)
IS  - 0034-8910 (Linking)
VI  - 45
IP  - 5
DP  - 2011 Oct
TI  - Conscientious objection and abortion: rights and duties of public sector
      physicians.
PG  - 981-5
LID - S0034-89102011005000047 [pii]
AB  - The paper analyzes conscientious objection by physicians, through the concrete
      situation of legal abortion in Brazil. It reviews the two main ethical frameworks
      about conscientious objection in public health, the incompatibility thesis and
      the integrity thesis, to analyze the reality of legal abortion services in the
      referral services of the Brazilian public health care system. From these two
      perspectives, a third perspective is proposed - the justification thesis, to
      manage the right to conscientious objection among physicians in referral
      services. This analysis may contribute to the organization of services for legal 
      abortion and to the education of future physicians working in emergency obstetric
      care.
FAU - Diniz, Debora
AU  - Diniz D
AD  - Instituto de Bioetica, Direitos Humanos e Genero, Universidade de Brasilia,
      Brasilia, DF, Brasil.
LA  - eng
LA  - por
PT  - Journal Article
DEP - 20110729
PL  - Brazil
TA  - Rev Saude Publica
JT  - Revista de saude publica
JID - 0135043
SB  - IM
MH  - Abortion, Legal/*ethics/legislation & jurisprudence
MH  - Bioethical Issues
MH  - Brazil
MH  - Conscience
MH  - Hospitals, Public
MH  - Humans
MH  - *Personal Autonomy
MH  - Physicians/*ethics
MH  - Refusal to Treat/*ethics
EDAT- 2011/08/03 06:00
MHDA- 2012/02/24 06:00
CRDT- 2011/08/03 06:00
PHST- 2010/10/18 00:00 [received]
PHST- 2011/04/15 00:00 [accepted]
PHST- 2011/08/03 06:00 [entrez]
PHST- 2011/08/03 06:00 [pubmed]
PHST- 2012/02/24 06:00 [medline]
AID - S0034-89102011005000047 [pii]
AID - 10.1590/s0034-89102011005000047 [doi]
PST - ppublish
SO  - Rev Saude Publica. 2011 Oct;45(5):981-5. doi: 10.1590/s0034-89102011005000047.
      Epub 2011 Jul 29.


PMID- 21808659
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1861-8863 (Electronic)
IS  - 1861-8863 (Linking)
VI  - 7
DP  - 2011
TI  - Prevention of alcohol misuse among children, youths and young adults.
PG  - Doc04
LID - 10.3205/hta000095 [doi]
AB  - BACKGROUND: Despite many activities to prevent risky alcohol consumption among
      adolescents and young adults there is an increase of alcohol intoxications in the
      group of ten to twenty year old juveniles. OBJECTIVES: This report gives an
      overview about the recent literature as well as the German federal prevention
      system regarding activities concerning behavioral and policy prevention of risky 
      alcohol consumption among children, adolescents and young adults. Furthermore,
      effective components of prevention activities are identified and the efficiency
      and efficacy of ongoing prevention programs is evaluated. METHODS: A systematic
      literature review is done in 34 databases using Bool'sche combinations of the key
      words alcohol, prevention, treatment, children, adolescents and young adults.
      RESULTS: 401 studies were found and 59 studies were selected for the health
      technology assessment (HTA). Most of the studies are done in USA, nine in
      Germany. A family strengthening program, personalized computer based intervention
      at schools, colleges and universities, brief motivational interventions and
      policy elements like increase of prices and taxes proved effective. DISCUSSION:
      Among the 59 studies there are three meta-analyses, 15 reviews, 17 randomized
      controlled trials (RCT) and 18 cohort studies. Despite the overall high quality
      of the study design, many of them have methodological weaknesses (missing
      randomization, missing or too short follow-ups, not clearly defined measurement
      parameters). The transferability of US-results to the German context is
      problematic. Only a few prevention activities reach a sustainable reduction of
      frequency and/or amount of alcohol consumption. CONCLUSION: The HTA-report shows 
      the need to develop specific and target group focused prevention activities for
      the German situation. Essential for that is the definition of target goals
      (reduction of consumption, change of behaviour) as well as the definition and
      empirical validation of risky alcohol consumption. The efficacy of prevention
      activities should be proven before they are launched. At present activities for
      the reduction or prevention of risky alcohol consumption are not sufficiently
      evaluated in Germany concerning their sustainable efficacy.
FAU - Korczak, Dieter
AU  - Korczak D
AD  - GP Forschungsgruppe, Institut fur Grundlagen- und Programmforschung, Munich,
      Germany.
FAU - Steinhauser, Gerlinde
AU  - Steinhauser G
FAU - Dietl, Markus
AU  - Dietl M
LA  - eng
PT  - Journal Article
DEP - 20110722
PL  - Germany
TA  - GMS Health Technol Assess
JT  - GMS health technology assessment
JID - 101276045
PMC - PMC3145353
OTO - NOTNLM
OT  - EBM
OT  - HTA
OT  - HTA report
OT  - HTA-report
OT  - RCT
OT  - abstinence from alcohol
OT  - academic review
OT  - accident
OT  - adolescent
OT  - aggressiveness
OT  - alcohol abuse
OT  - alcohol addiction
OT  - alcohol consumption
OT  - alcohol dependence
OT  - alcohol dependency
OT  - alcohol drinking
OT  - alcohol intervention
OT  - alcohol misuse
OT  - alcohol policy
OT  - alcohol prevention programs
OT  - alcohol taxation
OT  - alcohol use
OT  - alcohol use disorder
OT  - alcohol-related disorders
OT  - alcohol-related problems
OT  - alcoholic intoxication
OT  - alcoholism
OT  - at-risk college drinkers
OT  - at-risk drinking
OT  - behavior therapy
OT  - behavioral measures
OT  - behaviour therapy
OT  - benefit
OT  - binge drinking
OT  - binge-drinking
OT  - biomedical technology assessment
OT  - blinded
OT  - blinded study
OT  - blinded trial
OT  - blinding
OT  - blood alcohol
OT  - blood alcohol concentration
OT  - blood alcohol level
OT  - boy
OT  - brief motivational intervention
OT  - care
OT  - child
OT  - clinical study
OT  - clinical trial
OT  - clinical trials as topic
OT  - cognitive behavior therapy
OT  - cognitive behavioural therapy
OT  - community
OT  - community-based prevention
OT  - controlled clinical study
OT  - controlled clinical trial
OT  - controlled clinical trials as topic
OT  - cost
OT  - cost analysis
OT  - cost control
OT  - cost effectiveness
OT  - cost reduction
OT  - cost-benefit analyses
OT  - cost-cutting
OT  - cost-effectiveness
OT  - costs
OT  - costs and cost analysis
OT  - cross-over
OT  - cross-over studies
OT  - cross-over trials
OT  - crossover
OT  - decision making
OT  - diagnosis
OT  - drinking
OT  - drinking behavior
OT  - drinking behaviour
OT  - early adulthood
OT  - economic aspect
OT  - economic evaluation
OT  - economics
OT  - economics, medical
OT  - effectiveness
OT  - efficacy
OT  - efficiency
OT  - ethical aspects
OT  - ethics
OT  - evaluation studies as topic
OT  - evidence based medicine
OT  - evidence-based medicine
OT  - extraordinary tax
OT  - family
OT  - family therapy
OT  - hazardous drinking
OT  - health
OT  - health economic studies
OT  - health economics
OT  - health policy
OT  - health problem
OT  - health technology assessment
OT  - high school
OT  - humans
OT  - indicative prevention
OT  - inebriation
OT  - infant
OT  - intoxication
OT  - intoxication, alcoholic
OT  - judgment
OT  - juridical
OT  - kids
OT  - law
OT  - media campaign
OT  - medical assessment
OT  - medical costs
OT  - medical evaluation
OT  - meta analysis
OT  - meta analysis as topic
OT  - meta-analysis
OT  - methods
OT  - models, economic
OT  - motivation programme
OT  - mulitcentre
OT  - multicenter
OT  - multicenter studies as topic
OT  - multicenter trial
OT  - parents
OT  - peer review
OT  - pharmaeconomics
OT  - placebo
OT  - placebo effect
OT  - placebos
OT  - potential of aggressiveness
OT  - pre-teen
OT  - prevention
OT  - prevention campaign
OT  - primary prevention
OT  - program evaluation
OT  - prohibition
OT  - prophylaxis
OT  - prospective studies
OT  - protection
OT  - psychologic disorder
OT  - psychotherapy
OT  - random
OT  - random allocation
OT  - randomisation
OT  - randomised clinical study
OT  - randomised clinical trial
OT  - randomised controlled study
OT  - randomised controlled trial
OT  - randomised study
OT  - randomised trial
OT  - randomization
OT  - randomized clinical study
OT  - randomized clinical trial
OT  - randomized controlled study
OT  - randomized controlled trial
OT  - randomized controlled trials as topic
OT  - randomized study
OT  - randomized trial
OT  - rehabilitation
OT  - report
OT  - research article
OT  - research-article
OT  - review
OT  - review literature
OT  - review literature as topic
OT  - rights
OT  - risk assessment
OT  - school
OT  - school culture
OT  - school-based prevention
OT  - schools
OT  - sector-based prevention
OT  - selective prevention
OT  - sensitivity
OT  - sickness costs
OT  - social aspects
OT  - social care
OT  - social economic factors
OT  - social skills
OT  - social therapy
OT  - socioeconomic factors
OT  - socioeconomics
OT  - specifity
OT  - students
OT  - systematic review
OT  - tax increase
OT  - tax on alcohol
OT  - technical report
OT  - technology
OT  - technology assessment
OT  - technology assessment, biomedical
OT  - technology evaluation
OT  - technology, medical
OT  - teenager
OT  - therapy
OT  - treatment
OT  - trial, cross-over
OT  - trial, crossover
OT  - underage
OT  - undergraduates
OT  - universal prevention
OT  - universities
OT  - validation studies
OT  - validation studies as topic
OT  - young adult
OT  - youth
OT  - youth alcoholism
EDAT- 2011/08/03 06:00
MHDA- 2011/08/03 06:01
CRDT- 2011/08/03 06:00
PHST- 2011/08/03 06:00 [entrez]
PHST- 2011/08/03 06:00 [pubmed]
PHST- 2011/08/03 06:01 [medline]
AID - 10.3205/hta000095 [doi]
AID - hta000095 [pii]
PST - ppublish
SO  - GMS Health Technol Assess. 2011;7:Doc04. doi: 10.3205/hta000095. Epub 2011 Jul
      22.


PMID- 21808265
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20211020
IS  - 1759-4782 (Electronic)
IS  - 1759-4774 (Linking)
VI  - 8
IP  - 10
DP  - 2011 Aug 2
TI  - The ethical use of mandatory research biopsies.
PG  - 620-5
LID - 10.1038/nrclinonc.2011.114 [doi]
AB  - Increasingly, clinical trials incorporate translational research questions aimed 
      at identifying biomarkers of response or resistance to agents under
      investigation. Biomarker assays can require tissue samples to be collected
      through a research biopsy before therapy, during treatment, or at the time of
      tumor progression. Such biopsy samples will generally not provide a direct
      benefit to the patient and, given the risks associated with any surgical
      procedure, ethical concerns have been raised when the participant's enrollment on
      a clinical trial depends on their consent to undergo a research biopsy. In this
      Perspectives article, we present the rationale for mandatory research biopsies
      and offer suggestions for standardization to ensure that high-quality,
      patient-centered, clinical trials continue to be designed with scientific and
      ethical rigor.
FAU - Olson, Erin M
AU  - Olson EM
AD  - Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue,
      Boston, MA 02215, USA.
FAU - Lin, Nancy U
AU  - Lin NU
FAU - Krop, Ian E
AU  - Krop IE
FAU - Winer, Eric P
AU  - Winer EP
LA  - eng
GR  - K12 CA133250/CA/NCI NIH HHS/United States
PT  - Review
DEP - 20110802
PL  - England
TA  - Nat Rev Clin Oncol
JT  - Nature reviews. Clinical oncology
JID - 101500077
SB  - IM
CIN - Nat Rev Clin Oncol. 2012 Jan;9(1):64; author reply 64. PMID: 22158120
MH  - *Biomedical Research
MH  - Biopsy/methods
MH  - Clinical Trials as Topic/*ethics/methods/*standards
MH  - Humans
MH  - Informed Consent/*ethics
PMC - PMC3632075
MID - NIHMS458595
EDAT- 2011/08/03 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/08/03 06:00
PHST- 2011/08/03 06:00 [entrez]
PHST- 2011/08/03 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - nrclinonc.2011.114 [pii]
AID - 10.1038/nrclinonc.2011.114 [doi]
PST - epublish
SO  - Nat Rev Clin Oncol. 2011 Aug 2;8(10):620-5. doi: 10.1038/nrclinonc.2011.114.


PMID- 21808260
OWN - NLM
STAT- MEDLINE
DCOM- 20111017
LR  - 20211020
IS  - 1471-0064 (Electronic)
IS  - 1471-0056 (Linking)
VI  - 12
IP  - 9
DP  - 2011 Aug 2
TI  - Ethics watch: the G.I. genome: ethical implications of genome sequencing in the
      military.
PG  - 589
LID - 10.1038/nrg3063 [doi]
FAU - Allyse, Megan
AU  - Allyse M
AD  - Center for the Integration of Research on Genetics and Ethics, Stanford Center
      for Biomedical Ethics, Stanford University, 1215 Welch Road, Modular A, Stanford,
      California 94305, USA. megand@stanford.edu
FAU - Milner, Lauren C
AU  - Milner LC
FAU - Cho, Mildred K
AU  - Cho MK
LA  - eng
PT  - Journal Article
DEP - 20110802
PL  - England
TA  - Nat Rev Genet
JT  - Nature reviews. Genetics
JID - 100962779
SB  - IM
MH  - *Genome, Human
MH  - Humans
MH  - Military Personnel
MH  - Sequence Analysis, DNA
MH  - United States
MH  - United States Department of Defense/*ethics/*legislation & jurisprudence
EDAT- 2011/08/03 06:00
MHDA- 2011/10/18 06:00
CRDT- 2011/08/03 06:00
PHST- 2011/08/03 06:00 [entrez]
PHST- 2011/08/03 06:00 [pubmed]
PHST- 2011/10/18 06:00 [medline]
AID - nrg3063 [pii]
AID - 10.1038/nrg3063 [doi]
PST - epublish
SO  - Nat Rev Genet. 2011 Aug 2;12(9):589. doi: 10.1038/nrg3063.


PMID- 21808248
OWN - NLM
STAT- MEDLINE
DCOM- 20111208
LR  - 20171116
IS  - 1745-655X (Electronic)
IS  - 0197-5897 (Linking)
VI  - 32
IP  - 3
DP  - 2011 Aug
TI  - The Soviet legacy in diagnosis and treatment: Implications for population health.
PG  - 293-304
LID - 10.1057/jphp.2011.18 [doi]
AB  - This article reviews diagnosis and treatment in the Commonwealth of Independent
      States in three clinical areas: tuberculosis, substance misuse, and neurological 
      disorders in children. While the specific problems in each of these areas differ 
      greatly, commonalities emerge, pointing to the continued influence of the Soviet 
      past. Although progress in developing evidence-based medicine is being made, the 
      isolation of Soviet science from Western developments has resulted in the
      widespread use of outdated diagnostic procedures and treatment protocols, while
      finance mechanisms still encourage unnecessary hospitalizations and treatments. A
      hierarchical medical system, as well as underdeveloped patient rights and medical
      ethics, mean that patients have little information and ability to participate in 
      decision-making. The continued use of outdated approaches to diagnosis and
      treatment contributes to poor population health outcomes in the region.
FAU - Rechel, Boika
AU  - Rechel B
AD  - Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, UK.
FAU - Kennedy, Colin
AU  - Kennedy C
FAU - McKee, Martin
AU  - McKee M
FAU - Rechel, Bernd
AU  - Rechel B
LA  - eng
PT  - Journal Article
DEP - 20110512
PL  - England
TA  - J Public Health Policy
JT  - Journal of public health policy
JID - 8006508
SB  - IM
MH  - Adult
MH  - Child
MH  - Commonwealth of Independent States/epidemiology
MH  - Europe, Eastern/epidemiology
MH  - Evidence-Based Medicine
MH  - Global Health
MH  - HIV Infections/prevention & control
MH  - Health Services Accessibility/organization & administration
MH  - Humans
MH  - Nervous System Diseases/*diagnosis/*therapy
MH  - Patient Rights
MH  - Practice Guidelines as Topic
MH  - Primary Health Care/organization & administration
MH  - Social Environment
MH  - Substance Abuse, Intravenous/*diagnosis/*therapy
MH  - Tuberculosis/*diagnosis/*therapy
EDAT- 2011/08/03 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/08/03 06:00
PHST- 2011/08/03 06:00 [entrez]
PHST- 2011/08/03 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - jphp201118 [pii]
AID - 10.1057/jphp.2011.18 [doi]
PST - ppublish
SO  - J Public Health Policy. 2011 Aug;32(3):293-304. doi: 10.1057/jphp.2011.18. Epub
      2011 May 12.


PMID- 21808146
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20211020
IS  - 0971-5916 (Print)
IS  - 0971-5916 (Linking)
VI  - 134
DP  - 2011 Jul
TI  - Building ethical solidarity between public health & the press against
      HIV/AIDS-related stigma.
PG  - 124-7
FAU - Nambiar, Devaki
AU  - Nambiar D
LA  - eng
GR  - F31 MH076743/MH/NIMH NIH HHS/United States
GR  - F31 MH076743-01A1/MH/NIMH NIH HHS/United States
GR  - P30 MH043520/MH/NIMH NIH HHS/United States
PT  - Letter
PL  - India
TA  - Indian J Med Res
JT  - The Indian journal of medical research
JID - 0374701
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/*epidemiology
MH  - *HIV
MH  - Humans
MH  - Journalism/*ethics
MH  - Public Health/*ethics
MH  - *Social Stigma
PMC - PMC3171907
EDAT- 2011/08/03 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/08/03 06:00
PHST- 2011/08/03 06:00 [entrez]
PHST- 2011/08/03 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - IndianJMedRes_2011_134_1_124_83338 [pii]
PST - ppublish
SO  - Indian J Med Res. 2011 Jul;134:124-7.


PMID- 21808072
OWN - NLM
STAT- MEDLINE
DCOM- 20120510
LR  - 20151119
IS  - 1460-2229 (Electronic)
IS  - 0263-2136 (Linking)
VI  - 29
IP  - 1
DP  - 2012 Feb
TI  - Widespread use of pure and impure placebo interventions by GPs in Germany.
PG  - 79-85
LID - 10.1093/fampra/cmr045 [doi]
AB  - AIM: To collect data on the use of placebo interventions by GPs in Germany.
      METHODS: A questionnaire was mailed to 400 randomly selected GPs in Bavaria.
      Non-responders were reminded by telephone after 4 weeks and were given a second
      copy of the questionnaire after a further 3 weeks. RESULTS: In all, 208 completed
      questionnaires were returned. The majority of GPs (88%) have used a placebo at
      least once in their practice; 45% have used pure placebos, such as saline
      injections and sugar pills, at least once last year; the median frequency of use 
      was 5 [interquartile range (IQR), 2-10]. The use of impure placebos during the
      past year was more common: 76% of GPs have used impure placebos, i.e. medical
      interventions that have pharmacological or physical activity but have no
      intrinsic effect (e.g. pharmacological or physical action) on the patient's
      disease or its symptoms, with a median frequency of 20 times per year (IQR,
      10-50). The main reason for the use of placebo was a possible psychological
      effect, followed by the expectation of patients to receive a treatment. For the
      majority of GPs placebo interventions were ethically justified if they were used 
      for a possible psychological effect. CONCLUSIONS: Placebo interventions are a
      widely accepted part of medical treatment in German general practices and are
      used primarily for their psychological effects. Impure placebos are used much
      more frequently than pure placebos.
FAU - Meissner, Karin
AU  - Meissner K
AD  - Institute of Medical Psychology, Ludwig-Maximilians-University of Munich,
      Goethestrasse 31, 80336 Munich, Germany. karin.meissner@med.lmu.de
FAU - Hofner, Lisa
AU  - Hofner L
FAU - Fassler, Margrit
AU  - Fassler M
FAU - Linde, Klaus
AU  - Linde K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110801
PL  - England
TA  - Fam Pract
JT  - Family practice
JID - 8500875
RN  - 0 (Placebos)
SB  - IM
MH  - Female
MH  - *General Practice
MH  - Germany
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Placebos
MH  - *Practice Patterns, Physicians'
MH  - Surveys and Questionnaires
EDAT- 2011/08/03 06:00
MHDA- 2012/05/11 06:00
CRDT- 2011/08/03 06:00
PHST- 2011/08/03 06:00 [entrez]
PHST- 2011/08/03 06:00 [pubmed]
PHST- 2012/05/11 06:00 [medline]
AID - cmr045 [pii]
AID - 10.1093/fampra/cmr045 [doi]
PST - ppublish
SO  - Fam Pract. 2012 Feb;29(1):79-85. doi: 10.1093/fampra/cmr045. Epub 2011 Aug 1.


PMID- 21807959
OWN - NLM
STAT- MEDLINE
DCOM- 20120207
LR  - 20211203
IS  - 1552-7832 (Electronic)
IS  - 1043-6596 (Linking)
VI  - 22
IP  - 4
DP  - 2011 Oct
TI  - Culturally safe nursing research: exploring the use of an indigenous research
      methodology from an indigenous researcher's perspective.
PG  - 362-7
LID - 10.1177/1043659611414141 [doi]
AB  - Cultural safety is a familiar concept used in nursing education, research, and
      practice. It is also an important concept in nursing research and is one way of
      providing safety for indigenous participants and researchers, but it raises
      several questions, for one, who is the most appropriate person or persons to work
      in partnership with indigenous participants in research? Furthermore, who is the 
      most appropriate person to critique the academic research of an indigenous
      researcher? These questions are usually not considered when ethic committees
      review a researcher's application for research approval or funding. This article 
      defines cultural safety and the concern that indigenous students put aside their 
      culture when they commit to study within an education steeped in Westernized
      thinking. It discusses the decolonization of research and the part that
      nonindigenous researchers play within an indigenous research project. This
      article also outlines the application of an indigenous methodology and method in 
      a project that enabled participants and the researcher to develop a culturally
      safe process in the form of a metaphorical whanau (family). This was also
      reflected in the findings of the project when Maori students within a bachelor of
      nursing program formed whanau groups, which enabled them to succeed in their
      study.
FAU - McCleland, Ann
AU  - McCleland A
AD  - Eastern Institute of Technology, Napier, New Zealand. amccl@xtra.co.nz
LA  - eng
PT  - Journal Article
DEP - 20110801
PL  - United States
TA  - J Transcult Nurs
JT  - Journal of transcultural nursing : official journal of the Transcultural Nursing 
      Society
JID - 9001407
MH  - Colonialism
MH  - *Cultural Competency
MH  - Humans
MH  - *Native Hawaiian or Other Pacific Islander
MH  - New Zealand
MH  - Nursing Research/ethics/*methods
MH  - Race Relations
MH  - Research Personnel
MH  - *Safety
EDAT- 2011/08/03 06:00
MHDA- 2012/02/09 06:00
CRDT- 2011/08/03 06:00
PHST- 2011/08/03 06:00 [entrez]
PHST- 2011/08/03 06:00 [pubmed]
PHST- 2012/02/09 06:00 [medline]
AID - 1043659611414141 [pii]
AID - 10.1177/1043659611414141 [doi]
PST - ppublish
SO  - J Transcult Nurs. 2011 Oct;22(4):362-7. doi: 10.1177/1043659611414141. Epub 2011 
      Aug 1.


PMID- 21807335
OWN - NLM
STAT- MEDLINE
DCOM- 20111005
LR  - 20220318
IS  - 1474-5488 (Electronic)
IS  - 1470-2045 (Linking)
VI  - 12
IP  - 8
DP  - 2011 Aug
TI  - Ethical assessment of life-prolonging treatment.
PG  - 720-2
LID - 10.1016/S1470-2045(11)70148-6 [doi]
FAU - Winkler, Eva C
AU  - Winkler EC
AD  - National Center for Tumor Diseases, University of Heidelberg, Heidelberg,
      Germany. eva.winkler@med.uni-heidelberg.de
FAU - Hiddemann, Wolfgang
AU  - Hiddemann W
FAU - Marckmann, Georg
AU  - Marckmann G
LA  - eng
PT  - Journal Article
PL  - England
TA  - Lancet Oncol
JT  - The Lancet. Oncology
JID - 100957246
SB  - IM
MH  - Algorithms
MH  - Humans
MH  - *Life Support Care/ethics
MH  - Neoplasms/*therapy
MH  - *Withholding Treatment/ethics
EDAT- 2011/08/03 06:00
MHDA- 2011/10/06 06:00
CRDT- 2011/08/03 06:00
PHST- 2011/08/03 06:00 [entrez]
PHST- 2011/08/03 06:00 [pubmed]
PHST- 2011/10/06 06:00 [medline]
AID - S1470-2045(11)70148-6 [pii]
AID - 10.1016/S1470-2045(11)70148-6 [doi]
PST - ppublish
SO  - Lancet Oncol. 2011 Aug;12(8):720-2. doi: 10.1016/S1470-2045(11)70148-6.


PMID- 21805938
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20191112
IS  - 0748-321X (Print)
IS  - 0748-321X (Linking)
VI  - 38
IP  - 1
DP  - 2011 Spring
TI  - Can teaching veterinary and animal-science students about animal welfare affect
      their attitude toward animals and human-related empathy?
PG  - 74-83
AB  - Attitudes toward animals are important in influencing how animals are treated.
      Few studies have investigated attitudes toward animals in veterinary or
      animal-science students, and no studies have compared attitudes to animals before
      and after a course teaching animal welfare and ethics. In this study, students
      enrolled in veterinary (first-year) or animal-science (first- and third-year)
      programs completed a questionnaire on attitudes toward different categories of
      animals before and after the course. Higher attitude scores suggest a person more
      concerned about how an animal is treated. Normally distributed data were compared
      using parametric statistics, and non-normally distributed data were compared
      using non-parametric tests, with significance p < .05. Attitudes toward pets
      (45.5-47.6) were higher than those toward pests (34.2-38.4) or profit animals
      (30.3-32.1). Attitude scores increased from before to after the course in the
      veterinary cohort on the Pest (36.9 vs. 38.4, respectively, n = 27, p < .05) and 
      Profit (30.3 vs. 32.1, respectively, n = 28, p < .05) subscales, but not in the
      animal-science cohorts. Attitude scores in all categories were higher for women
      than for men. Currently having an animal was associated with higher pet scores
      (46.8 vs. 43.8, ns = 120 and 13, respectively, p < .05), and having an animal as 
      a child was associated with higher profit scores (31.0 vs. 26.6, ns = 129 and 8, 
      respectively, p < .05). Students electing to work with livestock had lower scores
      on the Pest and Profit subscales, and students wanting to work with wildlife had 
      significantly higher scores on the Pest and Profit subscales. This study
      demonstrates attitudinal changes after an animal-welfare course, with significant
      increases in veterinary but not animal-science students.
FAU - Hazel, Susan J
AU  - Hazel SJ
AD  - School of Animal and Veterinary Sciences, University of Adelaide, Roseworthy,
      Australia. susan.hazel@adelaide.edu.au
FAU - Signal, Tania D
AU  - Signal TD
FAU - Taylor, Nicola
AU  - Taylor N
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - J Vet Med Educ
JT  - Journal of veterinary medical education
JID - 7610519
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Animal Welfare
MH  - Animals
MH  - *Attitude of Health Personnel
MH  - Australia
MH  - Career Choice
MH  - Education, Veterinary
MH  - *Empathy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pets/psychology
MH  - Sex Distribution
MH  - Students, Health Occupations/*psychology/*statistics & numerical data
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2011/08/03 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/08/03 06:00
PHST- 2011/08/03 06:00 [entrez]
PHST- 2011/08/03 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - 10.3138/jvme.38.1.74 [doi]
PST - ppublish
SO  - J Vet Med Educ. 2011 Spring;38(1):74-83. doi: 10.3138/jvme.38.1.74.


PMID- 21805282
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20110801
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Linking)
VI  - 770
DP  - 2011
TI  - Laboratory guidelines for animal care.
PG  - 579-99
LID - 10.1007/978-1-61779-210-6_24 [doi]
AB  - Animal research is a controversial subject because of the ethical and moral
      implications of using unwilling research subjects in potentially painful or
      distressful procedures usually ending in euthanasia. As such, it must be
      conducted in a compassionate and responsible manner geared toward maximizing the 
      animals' quality of life prior to and during experimentation. Because of its
      contentious nature, the conduct of animal research is highly regulated at the
      federal, state, city, and institutional levels. It is essential that researchers 
      acquire a working knowledge of the procedures and regulations in order to protect
      themselves and their staff from occupational hazards as well as protect their
      labs from criticism or attack from animal rights organizations. Perhaps the best 
      way to protect from the latter is to avoid inadvertent instances of noncompliance
      with their research protocol or applicable regulations. Regulatory noncompliance 
      can also have serious negative consequences on investigators' research ranging
      from temporary suspension of their protocols to loss of funding or principal
      investigator status. To minimize such events, it is advised that researchers
      build positive and collaborative relationships, trust and rapport with key
      institutional players, such as the veterinary staff, the Institutional Animal
      Care and Use Committee (IACUC), and top administrators. Guidance is provided
      regarding the appropriate handling of regulatory noncompliances.
FAU - Couto, Marcelo
AU  - Couto M
AD  - UCLA School of Medicine-DLAM, Los Angeles, CA, USA. mcouto@mednet.ucla.edu
LA  - eng
PT  - Guideline
PT  - Journal Article
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
SB  - IM
MH  - *Animal Experimentation/ethics/legislation & jurisprudence/standards
MH  - *Animal Husbandry/ethics/legislation & jurisprudence/standards
MH  - Animal Welfare/ethics/legislation & jurisprudence/standards
MH  - Animals
MH  - *Animals, Laboratory/surgery
MH  - Euthanasia/ethics/legislation & jurisprudence
MH  - Government Regulation
MH  - Guideline Adherence/statistics & numerical data
MH  - Housing, Animal/ethics/legislation & jurisprudence/standards
MH  - Neuromuscular Blockade/ethics/standards
MH  - Pain/prevention & control
MH  - Research Report
MH  - Risk
EDAT- 2011/08/02 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/08/02 06:00
PHST- 2011/08/02 06:00 [entrez]
PHST- 2011/08/02 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - 10.1007/978-1-61779-210-6_24 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2011;770:579-99. doi: 10.1007/978-1-61779-210-6_24.


PMID- 21805213
OWN - NLM
STAT- MEDLINE
DCOM- 20131126
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 1
DP  - 2013 Mar
TI  - Data sharing and dual-use issues.
PG  - 83-92
LID - 10.1007/s11948-011-9298-7 [doi]
AB  - The concept of dual-use encapsulates the potential for well-intentioned,
      beneficial scientific research to also be misused by a third party for malicious 
      ends. The concept of dual-use challenges scientists to look beyond the immediate 
      outcomes of their research and to develop an awareness of possible future
      (mis)uses of scientific research. Since 2001 much attention has been paid to the 
      possible need to regulate the dual-use potential of the life sciences. Regulation
      initiatives fall under two broad categories-those that develop the ethical
      education of scientists and foster an awareness and responsibility of dual-use
      issues, and those which assess the regulation of information being generated by
      current research. Both types of initiatives are premised on a cautious,
      risk-adverse philosophy which advocates careful examination of all future
      endpoints of research endeavors. This caution advocated within initiatives such
      as pre-publication review of journal articles contrasts to the obligation to
      share underpinning data sharing discussions. As the dual-use debate has yet to
      make a significant impact on data sharing discussions (and vice versa) it is
      possible that these two areas of knowledge control may present areas of ethical
      conflict for scientists, and thus need to be more closely examined. This paper
      examines the tension between the obligation to share exemplified by data sharing 
      principles and the concerns raised by the risk-cautious culture of the dual-use
      debates. The paper concludes by reflecting on the issues of responsibility as
      raised by dual-use as relating to data sharing, such as the chain of custody for 
      shared data.
FAU - Bezuidenhout, Louise
AU  - Bezuidenhout L
AD  - Department of Sociology and Philosophy, University of Exeter, Exeter, UK.
      Lmb214@exeter.ac.uk
LA  - eng
GR  - 087351/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
DEP - 20110730
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Awareness
MH  - Biological Science Disciplines/*ethics/legislation & jurisprudence
MH  - *Crime
MH  - *Ethics, Research/education
MH  - Humans
MH  - Information Dissemination/*ethics
MH  - *Publishing
MH  - Risk
MH  - *Social Responsibility
PMC - PMC4727252
MID - EMS66138
OID - NLM: EMS66138
EDAT- 2011/08/02 06:00
MHDA- 2013/12/16 06:00
CRDT- 2011/08/02 06:00
PHST- 2011/06/20 00:00 [received]
PHST- 2011/07/15 00:00 [accepted]
PHST- 2011/08/02 06:00 [entrez]
PHST- 2011/08/02 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1007/s11948-011-9298-7 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Mar;19(1):83-92. doi: 10.1007/s11948-011-9298-7. Epub 2011
      Jul 30.


PMID- 21805147
OWN - NLM
STAT- MEDLINE
DCOM- 20120206
LR  - 20211020
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 23
IP  - 3
DP  - 2011 Sep
TI  - Institutional challenges for clinical ethics committees.
PG  - 193-205
LID - 10.1007/s10730-011-9160-y [doi]
AB  - Clinical ethics committees (CECs) have been developing in many countries since
      the 1980s, more recently in the transitional countries in Eastern Europe. With
      their increasing profile they are now faced with a range of questions and
      challenges regarding their position within the health care organizations in which
      they are situated: Should CECs be independent bodies with a critical role towards
      institutional management, or should they be an integral part of the hospital
      organization? In this paper, we discuss the organizational context in which CECs 
      function in Europe focusing on five aspects. We conclude that in Europe clinical 
      ethics committees need to maintain a critical independence while generating
      acceptance of the CEC and its potential benefit to both individuals and the
      organization. CECs, perhaps particularly in transitional countries, must counter 
      the charge of "alibi ethics". CECs must define their contribution to in-house
      quality management in their respective health care organization, clarifying how
      ethical reflection on various levels serves the hospital and patient care in
      general. This last challenge is made more difficult by lack of consensus about
      appropriate quality outcomes for CECs internationally. These are daunting
      challenges, but the fact that CECs continue to develop suggests that we should
      make the effort to overcome them. We believe there is a need for further research
      that specifically addresses some of the institutional challenges facing CECs.
FAU - Dorries, Andrea
AU  - Dorries A
AD  - Zentrum fur Gesundheitsethik (ZfG), Hannover, Germany. andrea.doerries@evlka.de
FAU - Boitte, Pierre
AU  - Boitte P
FAU - Borovecki, Ana
AU  - Borovecki A
FAU - Cobbaut, Jean-Philippe
AU  - Cobbaut JP
FAU - Reiter-Theil, Stella
AU  - Reiter-Theil S
FAU - Slowther, Anne-Marie
AU  - Slowther AM
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - Ethics Committees, Clinical/*ethics
MH  - *Ethics, Institutional
MH  - Europe
MH  - Humans
MH  - Interprofessional Relations/ethics
MH  - *Professional Autonomy
MH  - Professional Role
MH  - Quality Assurance, Health Care/*ethics
EDAT- 2011/08/02 06:00
MHDA- 2012/02/07 06:00
CRDT- 2011/08/02 06:00
PHST- 2011/08/02 06:00 [entrez]
PHST- 2011/08/02 06:00 [pubmed]
PHST- 2012/02/07 06:00 [medline]
AID - 10.1007/s10730-011-9160-y [doi]
PST - ppublish
SO  - HEC Forum. 2011 Sep;23(3):193-205. doi: 10.1007/s10730-011-9160-y.


PMID- 21805140
OWN - NLM
STAT- MEDLINE
DCOM- 20120409
LR  - 20211020
IS  - 1572-8595 (Electronic)
IS  - 1383-875X (Linking)
VI  - 32
IP  - 3
DP  - 2011 Dec
TI  - "Just Because We Can Doesn't Mean We Should": views of nurses on deactivation of 
      pacemakers and implantable cardioverter-defibrillators.
PG  - 243-52
LID - 10.1007/s10840-011-9596-7 [doi]
AB  - PURPOSE: This study aims to identify nurses' concerns about the clinical,
      ethical, and legal aspects of deactivating cardiovascular implantable electronic 
      devices (CIEDs). METHODS: We used focus groups to discuss decision making in CIED
      management. RESULTS: Fourteen nurses described the informed consent process as
      overly focused on procedures, with inadequate coverage of living with a device
      (e.g., infection risks and device shocks). Elderly patients were especially
      vulnerable to physician or family pressure about CIED implantation. Nurses
      believed that initial advance care planning discussions were infrequent and
      rarely revisited when health status changed. Many patients did not know that
      CIEDs could be deactivated; it was often addressed reactively (i.e., after
      multiple shocks) or when patients became too ill to participate in decision
      making. Nurses generally were supportive of CIED deactivation when it was
      requested by a well-informed patient. However, nurses distinguished between
      withholding versus withdrawing treatment (i.e., turning off CIEDs vs. declining
      implantation). Although most patients viewed their device as lifesaving, others
      perceived them as a "ticking time bomb." CONCLUSIONS: Nurses identified concerns 
      about CIED decision making from implantation through end-of-life care and device 
      deactivation and suggested avenues for improving patient care including early and
      regular advance care planning.
FAU - Kramer, Daniel B
AU  - Kramer DB
AD  - Beth Israel Deaconess Medical Center, Harvard Medical School, 185 Pilgrim Road,
      Baker 4, Boston, MA, 02215, USA. dkramer@bidmc.harvard.edu
FAU - Ottenberg, Abigale L
AU  - Ottenberg AL
FAU - Gerhardson, Samantha
AU  - Gerhardson S
FAU - Mueller, Luke A
AU  - Mueller LA
FAU - Kaufman, Sharon R
AU  - Kaufman SR
FAU - Koenig, Barbara A
AU  - Koenig BA
FAU - Mueller, Paul S
AU  - Mueller PS
LA  - eng
GR  - R01 AG028426/AG/NIA NIH HHS/United States
GR  - UL1 RR024150/RR/NCRR NIH HHS/United States
GR  - UL1 RR025758/RR/NCRR NIH HHS/United States
GR  - 1 UL1 RR 025758-02/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110730
PL  - Netherlands
TA  - J Interv Card Electrophysiol
JT  - Journal of interventional cardiac electrophysiology : an international journal of
      arrhythmias and pacing
JID - 9708966
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Defibrillators, Implantable/*ethics
MH  - Informed Consent/*ethics
MH  - Minnesota
MH  - Nurses/*statistics & numerical data
MH  - Pacemaker, Artificial/*ethics
MH  - Withholding Treatment/*ethics
PMC - PMC3733086
MID - NIHMS482366
EDAT- 2011/08/02 06:00
MHDA- 2012/04/10 06:00
CRDT- 2011/08/02 06:00
PHST- 2011/04/11 00:00 [received]
PHST- 2011/06/05 00:00 [accepted]
PHST- 2011/08/02 06:00 [entrez]
PHST- 2011/08/02 06:00 [pubmed]
PHST- 2012/04/10 06:00 [medline]
AID - 10.1007/s10840-011-9596-7 [doi]
PST - ppublish
SO  - J Interv Card Electrophysiol. 2011 Dec;32(3):243-52. doi:
      10.1007/s10840-011-9596-7. Epub 2011 Jul 30.


PMID- 21804803
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 0975-3125 (Electronic)
VI  - 5
IP  - 2
DP  - 2011 Apr
TI  - Comparison of respiratory quotient and resting energy expenditure in two regimens
      of enteral feeding - continuous vs. intermittent in head-injured critically ill
      patients.
PG  - 195-201
LID - 10.4103/1658-354X.82800 [doi]
AB  - INTRODUCTION: Measurement of respiratory quotient (RQ) and resting energy
      expenditure (REE) has been shown to be helpful in designing nutritional regimens.
      There is a paucity of the literature describing the impact of a feeding regimen
      on the energy expenditure patterns. Therefore, we studied the effect of
      continuous vs. intermittent feeding regimen in head-injured patients on
      mechanical ventilation on RQ and REE. METHODS: After institutional ethical
      approval, this randomized study was conducted in 40 adult male patients with head
      injury requiring controlled mode of ventilation. Patients were randomly allocated
      into two groups. Group C: Feeds (30 kcal/kg/day) were given for 18 h/day, with
      night rest for 6 h. Group I: Six bolus feeds (30 kcal/kg/day) were given three
      hourly for 18 h with night rest for 6 h. RQ and REE were recorded every 30 min
      for 24 h. Blood sugar was measured 4 hourly. Other adverse effects such as feed
      intolerance, aspiration were noted. RESULTS: Demographic profile and SOFA score
      were comparable in the two groups. Base line RQ (0.8 vs. 0.86) and REE (1527 vs. 
      1599 kcal/day) were comparable in both the groups (P>0.05). RQ was comparable in 
      both groups during the study period at any time of the day (P>0.05). Base line RQ
      was compared with all other RQ values measured every half hour and fluctuation
      from the base line value was insignificant in both groups (P>0.05). REE was
      comparable in both the groups throughout the study period (P>0.5). Adequacy of
      feeding as assessed by EI/MREE was 105.7% and 105.3% in group C and group I,
      respectively. There was no significant difference in the blood sugar levels
      between the two groups (P>0.05). CONCLUSION: We found from our study that RQ,
      REE, and blood sugar remain comparable with two regimens of enteral feeding -
      continuous vs. intermittent in neurosurgical patients on ventilator support in a 
      ICU setup.
FAU - Maurya, Indubala
AU  - Maurya I
AD  - Department of Anaesthesiology and Intensive Care, Postgraduate Institute of
      Medical Education and Research, Dr. Ram Manohar Lohia Hospital, New Delhi, India.
FAU - Pawar, Mridula
AU  - Pawar M
FAU - Garg, Rakesh
AU  - Garg R
FAU - Kaur, Mohandeep
AU  - Kaur M
FAU - Sood, Rajesh
AU  - Sood R
LA  - eng
PT  - Journal Article
PL  - India
TA  - Saudi J Anaesth
JT  - Saudi journal of anaesthesia
JID - 101500601
PMC - PMC3139315
OTO - NOTNLM
OT  - Blood sugar
OT  - continuous enteral feeding
OT  - intermittent enteral feeding
OT  - respiratory quotient
OT  - resting energy expenditure
EDAT- 2011/08/02 06:00
MHDA- 2011/08/02 06:01
CRDT- 2011/08/02 06:00
PHST- 2011/08/02 06:00 [entrez]
PHST- 2011/08/02 06:00 [pubmed]
PHST- 2011/08/02 06:01 [medline]
AID - 10.4103/1658-354X.82800 [doi]
AID - SJA-5-195 [pii]
PST - ppublish
SO  - Saudi J Anaesth. 2011 Apr;5(2):195-201. doi: 10.4103/1658-354X.82800.


PMID- 21804703
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20220408
IS  - 2231-2730 (Electronic)
IS  - 0970-9185 (Linking)
VI  - 27
IP  - 1
DP  - 2011 Jan
TI  - A comparison of Epidural Butorphanol and Tramadol for Postoperative Analgesia
      Using CSEA Technique.
PG  - 35-8
AB  - BACKGROUND: Post operative analgesia in patients undergoing lower limb surgery is
      very essential for immediate postoperative pain relief which can be provided by
      oral or parentral medication, epidural analgesia, local blocks etc.The study was 
      designed to evaluate the efficacy of epidural butorphanol and tramadol for
      postoperative pain relief. PATIENTS #ENTITYSTARTX00026; METHODS: This was
      randomized, prospective, double blind study was conducted on 60 patients, ASA
      grade I&II, age 18-60 undergoing lower limb surgeries after approval from
      hospital ethics committee. Group allocation - Group I I (n=30) received 2 mg
      butorphanol as bolus epidurally, 1 mg for top up dose. Group II (n=30) received
      100mg tramadol as bolus, 50 mg for top up. All the drugs were diluted to 10 ml
      normal saline & the observer was blinded to the drugs given. Postoperatively VAS,
      sedation score, vitals & side effects were observed. Top ups were given on
      achieving VAS>4. Diclofenac 75mg was given as rescue analgesia. RESULTS: Duration
      of analgesia was 5.35+/-0.29 hr and 6.25+/-1.58 hrs in Butorphanol and Tramadol
      groups respectively and the difference was found to be statistically significant.
      Pain scores were also significantly lower statistically in Group I as compared to
      Group II. Sedation scores were significantly higher in butorphanol group, whereas
      nausea vomiting was seen in tramadol group only (4 patients).No other side
      effects were observed. CONCLUSIONS: Both butorphanol and tramadol were effective 
      for relieving postoperative pain, however quality of analgesia & patient
      satisfaction was more with butorphanol.
FAU - Gupta, Ruchi
AU  - Gupta R
AD  - Professor & Head, Dept. of Anaesthesia, SGRDIMS & R, Amritsar - 143001, Punjab,
      India.
FAU - Kaur, Simmerpreet
AU  - Kaur S
FAU - Singh, Saru
AU  - Singh S
FAU - Aujla, K S
AU  - Aujla KS
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Anaesthesiol Clin Pharmacol
JT  - Journal of anaesthesiology, clinical pharmacology
JID - 9516972
PMC - PMC3141111
OTO - NOTNLM
OT  - Butorphanol
OT  - Epidural
OT  - Post-operative Pain
OT  - Tramadol
EDAT- 2011/08/02 06:00
MHDA- 2011/08/02 06:01
CRDT- 2011/08/02 06:00
PHST- 2011/08/02 06:00 [entrez]
PHST- 2011/08/02 06:00 [pubmed]
PHST- 2011/08/02 06:01 [medline]
PST - ppublish
SO  - J Anaesthesiol Clin Pharmacol. 2011 Jan;27(1):35-8.


PMID- 21804364
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20110928
IS  - 1538-2990 (Electronic)
IS  - 0002-9629 (Linking)
VI  - 342
IP  - 4
DP  - 2011 Oct
TI  - Payment of research subjects for more than minimal risk trials is unethical.
PG  - 294-6
LID - 10.1097/MAJ.0b013e318227e0a1 [doi]
AB  - This article explores the ethics of paying research participants for studies
      involving more than minimal risk using arguments grounded in morality, logic and 
      pragmatism, as well as patient responses from a focused qualitative study. The
      authors argue that payment of research participants is ethically unacceptable.
      Balanced against the probability of harmful risks, guaranteed payment to
      participants represents excessive and undue influence and leads to
      commodification of human health. Patients range in their opinions on whether
      payment for research participation is ethical, considering issues of justice and 
      nonmaleficence. From basic assumptions about the correlation between risks,
      financial need and willingness to participate in studies, the authors demonstrate
      that payments lead to unjustly influencing patients, especially the financially
      needy to participate in potentially harmful studies. Previous commentators have
      offered methods to regulate payment to participants, but these models do not seem
      feasible or ethically sound.
FAU - Wong, Janice C
AU  - Wong JC
AD  - Division of Neurosurgery, Toronto Western Hospital, University of Toronto,
      Toronto, Ontario, Canada.
FAU - Bernstein, Mark
AU  - Bernstein M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Med Sci
JT  - The American journal of the medical sciences
JID - 0370506
SB  - IM
MH  - Bioethical Issues
MH  - Clinical Trials as Topic/*economics/*ethics
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Patient Participation/economics
MH  - Risk
EDAT- 2011/08/02 06:00
MHDA- 2011/11/09 06:00
CRDT- 2011/08/02 06:00
PHST- 2011/08/02 06:00 [entrez]
PHST- 2011/08/02 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - 10.1097/MAJ.0b013e318227e0a1 [doi]
AID - S0002-9629(15)31158-7 [pii]
PST - ppublish
SO  - Am J Med Sci. 2011 Oct;342(4):294-6. doi: 10.1097/MAJ.0b013e318227e0a1.


PMID- 21804363
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20220317
IS  - 1538-2990 (Electronic)
IS  - 0002-9629 (Linking)
VI  - 342
IP  - 4
DP  - 2011 Oct
TI  - Informed consent: a critical part of modern medical research.
PG  - 273-5
LID - 10.1097/MAJ.0b013e318227e0cc [doi]
AB  - Informed consent is one of the great puzzles of modern medical research and
      practice. As Professor Henderson has argued in her article, there is ample reason
      to be concerned that many, and maybe all, of the goals announced for informed
      consent law and ethics have not been reached. In this article, I will review the 
      goals that theorists and judges have assigned to the doctrine and discuss some of
      the evidence concerning the difficulties of meeting those goals. Finally, I will 
      suggest some of the reasons that might account for our continued commitment to
      informed consent despite its difficulties.
FAU - Lidz, Charles W
AU  - Lidz CW
AD  - Center for Mental Health Services, University of Massachusetts, Worcester, MA
      01605, USA. chuck.lidz@umassmed.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Am J Med Sci
JT  - The American journal of the medical sciences
JID - 0370506
SB  - IM
MH  - Bioethical Issues
MH  - Disclosure/ethics/legislation & jurisprudence
MH  - Humans
MH  - *Informed Consent/ethics/legislation & jurisprudence
MH  - Translational Research, Biomedical/ethics/legislation & jurisprudence
EDAT- 2011/08/02 06:00
MHDA- 2011/11/09 06:00
CRDT- 2011/08/02 06:00
PHST- 2011/08/02 06:00 [entrez]
PHST- 2011/08/02 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - 10.1097/MAJ.0b013e318227e0cc [doi]
AID - S0002-9629(15)31154-X [pii]
PST - ppublish
SO  - Am J Med Sci. 2011 Oct;342(4):273-5. doi: 10.1097/MAJ.0b013e318227e0cc.


PMID- 21804362
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20110928
IS  - 1538-2990 (Electronic)
IS  - 0002-9629 (Linking)
VI  - 342
IP  - 4
DP  - 2011 Oct
TI  - Dispensing with equipoise.
PG  - 276-81
LID - 10.1097/MAJ.0b013e318227e871 [doi]
AB  - Equipoise is widely endorsed as a necessary requirement for ethical design and
      conduct of randomized controlled trials. Nevertheless, I argue in this article
      that the equipoise principle suffers from fundamental defects. In particular,
      equipoise provides flawed ethical guidance for placebo-controlled trials and for 
      decisions to terminate trials early based on interim data relating to benefit.
      The problems with equipoise are traced to a "therapeutic orientation to clinical 
      trials," which conflates the ethics of clinical research with the ethics of
      medical care. Because of this mistaken therapeutic orientation, equipoise fails
      to adequately account for the central purpose of randomized trials in providing
      evidence sufficient to guide health policy decisions relating to licensing new
      treatments and insurance coverage. I conclude that it is time to dispense with
      equipoise. The principles of research ethics are sufficient to provide adequate
      guidance to protect subjects and to promote socially valuable research without
      any appeal to equipoise.
FAU - Miller, Franklin G
AU  - Miller FG
AD  - Department of Bioethics, Clinical Center, National Institutes of Health, Building
      10, Room 1C118, Bethesda, MD 20892-1156, USA. fmiller@nih.gov
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Med Sci
JT  - The American journal of the medical sciences
JID - 0370506
SB  - IM
MH  - Bioethical Issues
MH  - Controlled Clinical Trials as Topic/ethics
MH  - Health Policy
MH  - Humans
MH  - Placebo Effect
MH  - Randomized Controlled Trials as Topic/*ethics
MH  - *Therapeutic Equipoise
EDAT- 2011/08/02 06:00
MHDA- 2011/11/09 06:00
CRDT- 2011/08/02 06:00
PHST- 2011/08/02 06:00 [entrez]
PHST- 2011/08/02 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - 10.1097/MAJ.0b013e318227e871 [doi]
AID - S0002-9629(15)31155-1 [pii]
PST - ppublish
SO  - Am J Med Sci. 2011 Oct;342(4):276-81. doi: 10.1097/MAJ.0b013e318227e871.


PMID- 21804097
OWN - NLM
STAT- MEDLINE
DCOM- 20120319
LR  - 20220317
IS  - 1464-3685 (Electronic)
IS  - 0300-5771 (Linking)
VI  - 40
IP  - 5
DP  - 2011 Oct
TI  - Is rigorous retrospective harmonization possible? Application of the DataSHaPER
      approach across 53 large studies.
PG  - 1314-28
LID - 10.1093/ije/dyr106 [doi]
AB  - BACKGROUND: Proper understanding of the roles of, and interactions between
      genetic, lifestyle, environmental and psycho-social factors in determining the
      risk of development and/or progression of chronic diseases requires access to
      very large high-quality databases. Because of the financial, technical and time
      burdens related to developing and maintaining very large studies, the scientific 
      community is increasingly synthesizing data from multiple studies to construct
      large databases. However, the data items collected by individual studies must be 
      inferentially equivalent to be meaningfully synthesized. The DataSchema and
      Harmonization Platform for Epidemiological Research (DataSHaPER;
      http://www.datashaper.org) was developed to enable the rigorous assessment of the
      inferential equivalence, i.e. the potential for harmonization, of selected
      information from individual studies. METHODS: This article examines the value of 
      using the DataSHaPER for retrospective harmonization of established studies.
      Using the DataSHaPER approach, the potential to generate 148 harmonized variables
      from the questionnaires and physical measures collected in 53 large
      population-based studies (6.9 million participants) was assessed. Variable and
      study characteristics that might influence the potential for data synthesis were 
      also explored. RESULTS: Out of all assessment items evaluated (148 variables for 
      each of the 53 studies), 38% could be harmonized. Certain characteristics of
      variables (i.e. relative importance, individual targeted, reference period) and
      of studies (i.e. observational units, data collection start date and mode of
      questionnaire administration) were associated with the potential for
      harmonization. For example, for variables deemed to be essential, 62% of
      assessment items paired could be harmonized. CONCLUSION: The current article
      shows that the DataSHaPER provides an effective and flexible approach for the
      retrospective harmonization of information across studies. To implement data
      synthesis, some additional scientific, ethico-legal and technical considerations 
      must be addressed. The success of the DataSHaPER as a harmonization approach will
      depend on its continuing development and on the rigour and extent of its use. The
      DataSHaPER has the potential to take us closer to a truly collaborative
      epidemiology and offers the promise of enhanced research potential generated
      through synthesized databases.
FAU - Fortier, Isabel
AU  - Fortier I
AD  - Research Institute - McGill University Health Centre, Montreal, Quebec, Canada.
      ifortier@p3g.org
FAU - Doiron, Dany
AU  - Doiron D
FAU - Little, Julian
AU  - Little J
FAU - Ferretti, Vincent
AU  - Ferretti V
FAU - L'Heureux, Francois
AU  - L'Heureux F
FAU - Stolk, Ronald P
AU  - Stolk RP
FAU - Knoppers, Bartha M
AU  - Knoppers BM
FAU - Hudson, Thomas J
AU  - Hudson TJ
FAU - Burton, Paul R
AU  - Burton PR
CN  - International Harmonization Initiative
LA  - eng
GR  - CZD/16/6/2/CSO_/Chief Scientist Office/United Kingdom
GR  - G0601625/MRC_/Medical Research Council/United Kingdom
GR  - 086160/Z/08/A/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110730
PL  - England
TA  - Int J Epidemiol
JT  - International journal of epidemiology
JID - 7802871
SB  - IM
MH  - Chronic Disease/epidemiology
MH  - Cohort Studies
MH  - Data Collection/*methods
MH  - *Data Interpretation, Statistical
MH  - Databases, Factual
MH  - Epidemiologic Methods
MH  - Humans
MH  - *Retrospective Studies
MH  - Risk Factors
MH  - Surveys and Questionnaires
PMC - PMC3204208
IR  - Banks E
FIR - Banks, Emily
IR  - Jorm L
FIR - Jorm, Louisa
IR  - Beane-Freeman L
FIR - Beane-Freeman, Laura
IR  - Hoppin JA
FIR - Hoppin, Jane A
IR  - Elliott P
FIR - Elliott, Paul
IR  - Singh D
FIR - Singh, Deepa
IR  - Hopper J
FIR - Hopper, John
IR  - Hopper J
FIR - Hopper, John
IR  - Rosenberg L
FIR - Rosenberg, Lynn
IR  - Palmer JR
FIR - Palmer, Julie R
IR  - Catlin G
FIR - Catlin, Gary
IR  - Wolfson M
FIR - Wolfson, Michael
IR  - Kirkland S
FIR - Kirkland, Susan
IR  - Raina P
FIR - Raina, Parminder
IR  - Wolfson C
FIR - Wolfson, Christina
IR  - Patel AV
FIR - Patel, Alpa V
IR  - Thun MJ
FIR - Thun, Michael J
IR  - Gapstur SM
FIR - Gapstur, Susan M
IR  - Thun MJ
FIR - Thun, Michael J
IR  - Laberge C
FIR - Laberge, Claude
IR  - Hakansson N
FIR - Hakansson, Niclas
IR  - Wolk A
FIR - Wolk, Alicja
IR  - Goldberg M
FIR - Goldberg, Marcel
IR  - Zins M
FIR - Zins, Marie
IR  - Borugian M
FIR - Borugian, Marilyn
IR  - Gallagher RP
FIR - Gallagher, Richard P
IR  - McLaughlin J
FIR - McLaughlin, John
IR  - Parker L
FIR - Parker, Louise
IR  - Potter JD
FIR - Potter, John D
IR  - Robson P
FIR - Robson, Paula
IR  - Ellervik C
FIR - Ellervik, Christina
IR  - Barricarte A
FIR - Barricarte, Aurelio
IR  - Berrino F
FIR - Berrino, Franco
IR  - Boeing H
FIR - Boeing, Heiner
IR  - Boutron-Ruault MC
FIR - Boutron-Ruault, Marie-Christine
IR  - Bueno-de-Mesquita HB
FIR - Bueno-de-Mesquita, H Bas
IR  - Clavel-Chapelon F
FIR - Clavel-Chapelon, Francoise
IR  - Dorronsoro M
FIR - Dorronsoro, Miren
IR  - Gonzalez CA
FIR - Gonzalez, Carlos A
IR  - Hallmans G
FIR - Hallmans, Goran
IR  - Kaaks R
FIR - Kaaks, Rudolf
IR  - Kaw KT
FIR - Kaw, Kay-Tee
IR  - Key TJ
FIR - Key, Tim J
IR  - Lund E
FIR - Lund, Eiliv
IR  - Manjer J
FIR - Manjer, Jonas
IR  - Mouw T
FIR - Mouw, Traci
IR  - Navarro C
FIR - Navarro, Carmen
IR  - Overvad K
FIR - Overvad, Kim
IR  - Palli D
FIR - Palli, Domenico
IR  - Panico S
FIR - Panico, Salvatore
IR  - Peeters PH
FIR - Peeters, Petra H M
IR  - Riboli E
FIR - Riboli, Elio
IR  - Rodriguez L
FIR - Rodriguez, Laudina
IR  - Romieu I
FIR - Romieu, Isabelle
IR  - Sanchez J
FIR - Sanchez, Jose
IR  - Slimani N
FIR - Slimani, Nadia
IR  - Tjonneland A
FIR - Tjonneland, Anne
IR  - Trichopoulou A
FIR - Trichopoulou, Antonia
IR  - Tumino R
FIR - Tumino, Rosario
IR  - Vineis P
FIR - Vineis, Paolo
IR  - Alavere H
FIR - Alavere, Helen
IR  - Metspalu A
FIR - Metspalu, Andres
IR  - Perola M
FIR - Perola, Markus
IR  - Goldberg M
FIR - Goldberg, Marcel
IR  - Zins M
FIR - Zins, Marie
IR  - Linksted P
FIR - Linksted, Pamela
IR  - Morris AD
FIR - Morris, Andrew D
IR  - Klovins J
FIR - Klovins, Janis
IR  - Tarasova L
FIR - Tarasova, Linda
IR  - Inoue M
FIR - Inoue, Manami
IR  - Tsugane S
FIR - Tsugane, Shoichiro
IR  - Inoue M
FIR - Inoue, Manami
IR  - Tsugane S
FIR - Tsugane, Shoichiro
IR  - Doring A
FIR - Doring, Angela
IR  - Wichmann HE
FIR - Wichmann, H Erich
IR  - Chen Z
FIR - Chen, Zhengming
IR  - Li L
FIR - Li, Liming
IR  - Schaefer C
FIR - Schaefer, Catherine
IR  - Walter L
FIR - Walter, Larry
IR  - Park SK
FIR - Park, Sue K
IR  - Yoo KY
FIR - Yoo, Keun-Young
IR  - Eriksson M
FIR - Eriksson, Mikael
IR  - Pedersen N
FIR - Pedersen, Nancy
IR  - Keers J
FIR - Keers, Joost
IR  - Wolffenbuttel BH
FIR - Wolffenbuttel, Bruce H R
IR  - Manjer J
FIR - Manjer, Jonas
IR  - Nilsson P
FIR - Nilsson, Peter
IR  - English DR
FIR - English, Dallas R
IR  - Bondy M
FIR - Bondy, Melissa
IR  - Wilkinson A
FIR - Wilkinson, Anna
IR  - De Curtis A
FIR - De Curtis, Amalia
IR  - Iacoviello L
FIR - Iacoviello, Licia
IR  - Dube MP
FIR - Dube, Marie-Pierre
IR  - Laplante N
FIR - Laplante, Nathalie
IR  - Tardif JC
FIR - Tardif, Jean-Claude
IR  - Schatzkin A
FIR - Schatzkin, Arthur
IR  - Park Y
FIR - Park, Yikyung
IR  - Chisholm RL
FIR - Chisholm, Rex L
IR  - Wolf WA
FIR - Wolf, Wendy A
IR  - Johnson J
FIR - Johnson, Jon
IR  - Garcia-Montero A
FIR - Garcia-Montero, Andres
IR  - Orfao A
FIR - Orfao, Alberto
IR  - Perola M
FIR - Perola, Markus
IR  - McLean JE
FIR - McLean, Jody E
IR  - McQuillan GM
FIR - McQuillan, Geraldine M
IR  - McLean JE
FIR - McLean, Jody E
IR  - McQuillan GM
FIR - McQuillan, Geraldine M
IR  - Hveem K
FIR - Hveem, Kristian
IR  - Dumeaux V
FIR - Dumeaux, Vanessa
IR  - Lund E
FIR - Lund, Eiliv
IR  - Galan P
FIR - Galan, Pilar
IR  - Hercberg S
FIR - Hercberg, Serge
IR  - Magnusson PK
FIR - Magnusson, Patrik K E
IR  - Chia KS
FIR - Chia, Kee-Seng
IR  - Loy EY
FIR - Loy, En Yun
IR  - DeRoo LA
FIR - DeRoo, Lisa A
IR  - Sandler DP
FIR - Sandler, Dale P
IR  - Hakansson N
FIR - Hakansson, Niclas
IR  - Wolk A
FIR - Wolk, Alicja
IR  - Magnusson PK
FIR - Magnusson, Patrik K E
IR  - Collins R
FIR - Collins, Rory
IR  - Peakman T
FIR - Peakman, Tim
IR  - Burley VJ
FIR - Burley, Victoria J
IR  - Cade J
FIR - Cade, Janet
IR  - Greenwood DC
FIR - Greenwood, Darren C
IR  - Hutter CM
FIR - Hutter, Carolyn M
IR  - White E
FIR - White, Emily
IR  - Palmer LJ
FIR - Palmer, Lyle J
IR  - L'Heureux F
FIR - L'Heureux, Francois
IR  - Lachance G
FIR - Lachance, Genevieve
IR  - Thiebault C
FIR - Thiebault, Cedric
IR  - Vilain A
FIR - Vilain, Anne
IR  - Naccache M
FIR - Naccache, Mayss
IR  - Sanogo F
FIR - Sanogo, Ferima
IR  - Morency-Bachand E
FIR - Morency-Bachand, Etienne
IR  - Tamisier C
FIR - Tamisier, Clement
IR  - Atkinson SA
FIR - Atkinson, Susan A
IR  - Rengifo A
FIR - Rengifo, Andrea
IR  - Deschenes M
FIR - Deschenes, Mylene
EDAT- 2011/08/02 06:00
MHDA- 2012/03/20 06:00
CRDT- 2011/08/02 06:00
PHST- 2011/08/02 06:00 [entrez]
PHST- 2011/08/02 06:00 [pubmed]
PHST- 2012/03/20 06:00 [medline]
AID - dyr106 [pii]
AID - 10.1093/ije/dyr106 [doi]
PST - ppublish
SO  - Int J Epidemiol. 2011 Oct;40(5):1314-28. doi: 10.1093/ije/dyr106. Epub 2011 Jul
      30.


PMID- 21804066
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20190709
IS  - 1943-4723 (Electronic)
IS  - 0002-8177 (Linking)
VI  - 142
IP  - 8
DP  - 2011 Aug
TI  - What are the ethical issues I need to consider when developing marketing
      strategies for my practice?
PG  - 966-7
FAU - Wentworth, Rod B
AU  - Wentworth RB
AD  - American Dental Association Council on Ethics, Bylaws and Judicial Affairs,
      Chicago, Ill. 60611, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Am Dent Assoc
JT  - Journal of the American Dental Association (1939)
JID - 7503060
SB  - IM
CIN - J Am Dent Assoc. 2011 Nov;142(11):1234; author reply 1234-5. PMID: 22041406
MH  - Dentist-Patient Relations/ethics
MH  - Dentists/*ethics/legislation & jurisprudence
MH  - *Ethics, Dental
MH  - Humans
MH  - Marketing of Health Services/*ethics/legislation & jurisprudence
MH  - Motivation/ethics
MH  - Patient Education as Topic/ethics
MH  - Practice Management, Dental/*ethics/legislation & jurisprudence
MH  - Truth Disclosure/ethics
MH  - United States
EDAT- 2011/08/02 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/08/02 06:00
PHST- 2011/08/02 06:00 [entrez]
PHST- 2011/08/02 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0002-8177(14)62074-2 [pii]
AID - 10.14219/jada.archive.2011.0306 [doi]
PST - ppublish
SO  - J Am Dent Assoc. 2011 Aug;142(8):966-7. doi: 10.14219/jada.archive.2011.0306.


PMID- 21802813
OWN - NLM
STAT- MEDLINE
DCOM- 20120423
LR  - 20120229
IS  - 1531-5053 (Electronic)
IS  - 0278-2391 (Linking)
VI  - 70
IP  - 3
DP  - 2012 Mar
TI  - The deep inferior epigastric artery perforator (DIEAP) flap for total glossectomy
      reconstruction.
PG  - 740-7
LID - 10.1016/j.joms.2011.02.098 [doi]
AB  - PURPOSE: Total or subtotal glossectomy following the resection of intraoral
      tumors causes significant morbidity. However, which reconstructive technique is
      the most successful remains controversial. PATIENTS AND METHODS: After approval
      by the Ethics Committee, charts were reviewed retrospectively for patients
      treated at the Oral and Maxillofacial Surgery Department, University Hospital La 
      Paz (Madrid, Spain), during a 3-year period (2005-2008). All were reconstructed
      with a deep inferior epigastric artery perforator (DIEAP) flap after total
      glossectomy. Data collected included affiliation data, extent of extirpation,
      type of reconstruction, and surgical outcome, including donor-site morbidity,
      complications, and functional results. RESULTS: Seven patients (5 men, 71.4%; 2
      women, 28.6%) with primary squamous cell carcinoma of the tongue underwent total 
      glossectomy and simultaneous microsurgical reconstruction with a DIEAP flap. In
      all cases, the flap was harvested with a fusiform shape oriented craniocaudally
      and limited to zone 1. The average size of the flap was 16.7 x 7.2 cm. Functional
      outcome related to swallowing was poor; 57.1% of the patients required a
      permanent gastrostomy. Speech was considered intelligible in 85.7% of cases by 2 
      independent observers. The surgical outcome was uneventful in most of the cases, 
      with only 1 case of local dehiscence at the mouth floor. None of the cases
      developed abdominal wall dehiscence or an abdominal hernia at mid- or long-term
      follow-up. CONCLUSIONS: The DIEAP flap is a reliable alternative for tongue
      reconstruction. It provides a large volume of soft tissue for transfer and is
      predictable and stable over time with low donor-site morbidity.
CI  - Copyright A(c) 2012 American Association of Oral and Maxillofacial Surgeons.
      Published by Elsevier Inc. All rights reserved.
FAU - Lopez-Arcas, Jose Maria
AU  - Lopez-Arcas JM
AD  - Oral and Maxillofacial Surgery Department, Hospital Sanitas La Moraleja, Madrid, 
      Spain. jmloparc@yahoo.es
FAU - Arias, Javier
AU  - Arias J
FAU - Moran, Maria Jose
AU  - Moran MJ
FAU - Navarro, Ignacio
AU  - Navarro I
FAU - Pingarron, Lorena
AU  - Pingarron L
FAU - Chamorro, Manuel
AU  - Chamorro M
FAU - Burgueno, Miguel
AU  - Burgueno M
LA  - eng
PT  - Journal Article
DEP - 20110729
PL  - United States
TA  - J Oral Maxillofac Surg
JT  - Journal of oral and maxillofacial surgery : official journal of the American
      Association of Oral and Maxillofacial Surgeons
JID - 8206428
SB  - IM
MH  - Aged
MH  - Carcinoma, Adenoid Cystic/pathology/rehabilitation/*surgery
MH  - Carcinoma, Squamous Cell/pathology/rehabilitation/*surgery
MH  - Deglutition
MH  - Female
MH  - *Free Tissue Flaps/blood supply
MH  - Glossectomy/methods/*rehabilitation
MH  - Graft Survival
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Reconstructive Surgical Procedures/*methods
MH  - Retrospective Studies
MH  - Speech Intelligibility
MH  - Tongue Neoplasms/pathology/rehabilitation/*surgery
EDAT- 2011/08/02 06:00
MHDA- 2012/04/24 06:00
CRDT- 2011/08/02 06:00
PHST- 2010/08/21 00:00 [received]
PHST- 2011/01/23 00:00 [revised]
PHST- 2011/02/16 00:00 [accepted]
PHST- 2011/08/02 06:00 [entrez]
PHST- 2011/08/02 06:00 [pubmed]
PHST- 2012/04/24 06:00 [medline]
AID - S0278-2391(11)00326-0 [pii]
AID - 10.1016/j.joms.2011.02.098 [doi]
PST - ppublish
SO  - J Oral Maxillofac Surg. 2012 Mar;70(3):740-7. doi: 10.1016/j.joms.2011.02.098.
      Epub 2011 Jul 29.


PMID- 21802741
OWN - NLM
STAT- MEDLINE
DCOM- 20121009
LR  - 20181201
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 136
IP  - 3
DP  - 2012 Feb
TI  - Risk constellations prior to the development of bipolar disorders: rationale of a
      new risk assessment tool.
PG  - 1000-10
LID - 10.1016/j.jad.2011.06.043 [doi]
AB  - BACKGROUND: The precise characterisation of a high risk status for the
      development of a psychiatric disorder and the question of how well this predicts 
      disease manifestation is of major importance as negative consequences of late
      diagnosis and treatment have been well demonstrated. In the absence of well
      defined and disease specific biological markers for bipolar disorder, the
      recognition of premature stages must rely on combinations of risk factors that
      have been associated with later disease manifestation. METHODS: A review of the
      literature and our experience from the Early Recognition Centre led us to
      identify symptom constellations. RESULTS: Individual categories defined and
      grouped included: (I) genetic risk, (II) substance use, misuse or dependence,
      (III) diagnosis/suspected diagnosis of attention deficit hyperactivity disorder, 
      (IV) pronounced creativity, (V) impairment in psychosocial functioning, (VI)
      subthreshold affective symptoms, and (VII) early symptomatology including (a)
      changes in sleep and circadian rhythm, (b) changes in mood, mood swings/affective
      lability, (c) fearfulness/anxiety, and (d) dissociative symptoms. These risk
      constellations were operationalised and a new risk assessment instrument, the
      Early Phase Inventory for Bipolar Disorders (EPIbipolar) was developed.
      LIMITATIONS: Challenges regarding the validity of the data on which the
      instrument is based, specificity of and correlations between risk categories, and
      ethical considerations were encountered. CONCLUSIONS: Further use of EPIbipolar
      in research should help to refine prodromal features and narrow these down to a
      less cumbersome core that can be used to develop a shortened tool for use in
      clinical care. Prospective longitudinal research is needed to establish the
      predictive validity of this novel bipolar disorder risk assessment tool.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Leopold, Karolina
AU  - Leopold K
AD  - Department of Psychiatry and Psychotherapy, Carl Gustav Carus University
      Hospital, Technische Universitat Dresden, Germany.
FAU - Ritter, Philipp
AU  - Ritter P
FAU - Correll, Christoph U
AU  - Correll CU
FAU - Marx, Carolin
AU  - Marx C
FAU - Ozgurdal, Seza
AU  - Ozgurdal S
FAU - Juckel, Georg
AU  - Juckel G
FAU - Bauer, Michael
AU  - Bauer M
FAU - Pfennig, Andrea
AU  - Pfennig A
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110730
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
SB  - IM
MH  - Bipolar Disorder/*diagnosis/etiology/psychology
MH  - Humans
MH  - Male
MH  - Risk Assessment
MH  - Risk Factors
EDAT- 2011/08/02 06:00
MHDA- 2012/10/10 06:00
CRDT- 2011/08/02 06:00
PHST- 2011/05/11 00:00 [received]
PHST- 2011/06/28 00:00 [accepted]
PHST- 2011/08/02 06:00 [entrez]
PHST- 2011/08/02 06:00 [pubmed]
PHST- 2012/10/10 06:00 [medline]
AID - S0165-0327(11)00394-6 [pii]
AID - 10.1016/j.jad.2011.06.043 [doi]
PST - ppublish
SO  - J Affect Disord. 2012 Feb;136(3):1000-10. doi: 10.1016/j.jad.2011.06.043. Epub
      2011 Jul 30.


PMID- 21802330
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20110930
IS  - 1878-3511 (Electronic)
IS  - 1201-9712 (Linking)
VI  - 15
IP  - 10
DP  - 2011 Oct
TI  - Comparison of two strategies to prevent varicella outbreaks in housing facilities
      for asylum seekers.
PG  - e716-21
LID - 10.1016/j.ijid.2011.06.001 [doi]
AB  - BACKGROUND: The proportion of adults with positive varicella serology is lower in
      populations from tropical countries. Therefore immigrants to countries with a
      temperate climate are at risk of acquiring varicella infection during adulthood. 
      METHODS: We tested two different strategies to prevent varicella outbreaks in
      housing facilities for asylum seekers arriving in the Canton of Vaud,
      Switzerland. The first strategy consisted of a rapid response with isolation of
      the affected individuals and vaccination of the susceptible contacts. The second 
      strategy consisted of a general vaccination upon arrival of all asylum seekers
      aged 15-39 years with no history of chickenpox. RESULTS: From May 2008 to January
      2009 we applied the rapid response strategy. Eight hundred and fifty-eight asylum
      seekers arrived in the Canton and an attack rate of 2.8% (seven cases among 248
      exposed asylum seekers) was observed. The mean cost was US$ 31.35 per asylum
      seeker. The general vaccination strategy was applied from February 2009 to May
      2010, a period during which 966 asylum seekers were registered. This second
      strategy completely prevented any outbreak at a mean cost of US$ 83.85 per asylum
      seeker. CONCLUSIONS: Of the two analyzed interventions to prevent varicella
      outbreaks in housing facilities for asylum seekers, the general vaccination
      strategy was more effective, more sustainable, and ethically preferable, although
      more costly.
CI  - Copyright (c) 2011 International Society for Infectious Diseases. Published by
      Elsevier Ltd. All rights reserved.
FAU - de Valliere, Serge
AU  - de Valliere S
AD  - Department of Ambulatory Care and Community Medicine, University Hospital of
      Lausanne, Av du Bugnon 44, 1011 Lausanne, Switzerland.
      serge.de-valliere@hospvd.ch
FAU - Cani, Naim
AU  - Cani N
FAU - Grossenbacher, Maya
AU  - Grossenbacher M
FAU - Puig, Francisco
AU  - Puig F
FAU - Masserey, Eric
AU  - Masserey E
FAU - Bodenmann, Patrick
AU  - Bodenmann P
LA  - eng
PT  - Journal Article
DEP - 20110728
PL  - Canada
TA  - Int J Infect Dis
JT  - International journal of infectious diseases : IJID : official publication of the
      International Society for Infectious Diseases
JID - 9610933
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Chickenpox/*epidemiology/*prevention & control
MH  - Child
MH  - Child, Preschool
MH  - Disease Outbreaks/*prevention & control
MH  - Female
MH  - *Herpesvirus 3, Human/immunology
MH  - Humans
MH  - Male
MH  - Patient Isolation/economics
MH  - *Refugees
MH  - Switzerland/epidemiology/ethnology
MH  - Vaccination/economics
MH  - Young Adult
EDAT- 2011/08/02 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/08/02 06:00
PHST- 2010/12/21 00:00 [received]
PHST- 2011/05/31 00:00 [revised]
PHST- 2011/06/06 00:00 [accepted]
PHST- 2011/08/02 06:00 [entrez]
PHST- 2011/08/02 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - S1201-9712(11)00131-7 [pii]
AID - 10.1016/j.ijid.2011.06.001 [doi]
PST - ppublish
SO  - Int J Infect Dis. 2011 Oct;15(10):e716-21. doi: 10.1016/j.ijid.2011.06.001. Epub 
      2011 Jul 28.


PMID- 21802102
OWN - NLM
STAT- MEDLINE
DCOM- 20111130
LR  - 20181201
IS  - 1776-257X (Electronic)
IS  - 0035-1768 (Linking)
VI  - 112
IP  - 4
DP  - 2011 Sep
TI  - [Biological dental implant: myth or reality?].
PG  - 240-8
LID - 10.1016/j.stomax.2011.06.005 [doi]
AB  - The currently available options for tooth-loss are prostheses, implants, or
      surgery (auto-transplantation). They all have their limitations. The emergence of
      tissue engineering, 15 years ago, was made possible by a better knowledge of the 
      various stages of dental development, and the mastery of stem cell
      differentiation. It opened a new alternative approach for tooth regeneration.
      Even if animal experiments have demonstrated that it was possible to obtain a
      biological tooth from stem cells, two major issues remain to be discussed. Is it 
      possible to use induced pluripotent stem cells instead of embryonic stem cells,
      which raise an ethical problem? Is it possible to reproduce a dental crown with
      an adapted shape and colour? Or should we consider the simpler creation of a
      biological root secondarily covered by a ceramic prosthesis? Our study mentions
      the main landmarks and the key cells involved in the embryological development of
      the tooth, establishes a mapping and a list of the various types of stem cells.
      It details the various methods used to create a biological implant.
CI  - Copyright (c) 2011 Elsevier Masson SAS. All rights reserved.
FAU - Magloire, H
AU  - Magloire H
AD  - Institut de genomique fonctionnelle de Lyon, << equipe physiopathologie de
      l'odontoblaste >>, UMR CNRS 5242, Ecole normale superieure de Lyon, 46, allee
      d'Italie, 69364 Lyon cedex 08, France. magloire@univ-lyon1.fr
FAU - Couble, M-L
AU  - Couble ML
LA  - fre
PT  - Journal Article
TT  - L'implant dentaire biologique : mythe ou realite ?
DEP - 20110728
PL  - France
TA  - Rev Stomatol Chir Maxillofac
JT  - Revue de stomatologie et de chirurgie maxillo-faciale
JID - 0201010
SB  - IM
MH  - Animals
MH  - Cell Culture Techniques
MH  - Costs and Cost Analysis
MH  - Dental Pulp/*cytology
MH  - Humans
MH  - Induced Pluripotent Stem Cells
MH  - Mesenchymal Stem Cells
MH  - *Odontogenesis/genetics
MH  - *Regeneration
MH  - *Stem Cells
MH  - *Tissue Engineering
MH  - Tooth/*embryology/growth & development
MH  - Tooth Crown/growth & development
MH  - Tooth Germ/cytology
MH  - Tooth Root/growth & development
EDAT- 2011/08/02 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/08/02 06:00
PHST- 2011/08/02 06:00 [entrez]
PHST- 2011/08/02 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0035-1768(11)00110-0 [pii]
AID - 10.1016/j.stomax.2011.06.005 [doi]
PST - ppublish
SO  - Rev Stomatol Chir Maxillofac. 2011 Sep;112(4):240-8. doi:
      10.1016/j.stomax.2011.06.005. Epub 2011 Jul 28.


PMID- 21801901
OWN - NLM
STAT- MEDLINE
DCOM- 20111007
LR  - 20211020
IS  - 1552-6259 (Electronic)
IS  - 0003-4975 (Linking)
VI  - 92
IP  - 2
DP  - 2011 Aug
TI  - Ethics in cardiothoracic surgery. Point: Full disclosure--presentations and
      publications should include dollar amounts and duration of surgeon-industry
      relationships.
PG  - 413-16
LID - 10.1016/j.athoracsur.2011.05.079 [doi]
FAU - Murphy, J Peter
AU  - Murphy JP
AD  - Department of Cardiovascular Surgery, Missouri Baptist Hospital, St. Louis,
      Missouri 63131, USA. jpm0529@bjc.org
LA  - eng
GR  - UL1 RR029882/RR/NCRR NIH HHS/United States
GR  - UL1 RR029882-03/RR/NCRR NIH HHS/United States
GR  - UL1RR029882/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Comment
PL  - Netherlands
TA  - Ann Thorac Surg
JT  - The Annals of thoracic surgery
JID - 15030100R
SB  - IM
CON - Ann Thorac Surg. 2011 Aug;92(2):417-20. PMID: 21801902
MH  - Conflict of Interest/*economics/legislation & jurisprudence
MH  - Data Collection/economics/ethics/legislation & jurisprudence
MH  - Disclosure/*ethics
MH  - Employment/economics/ethics/legislation & jurisprudence
MH  - *Ethics, Medical
MH  - Humans
MH  - Industry/*economics/*ethics/legislation & jurisprudence
MH  - Patient Protection and Affordable Care Act/economics/legislation & jurisprudence
MH  - Publishing/*economics/*ethics/legislation & jurisprudence
MH  - Referral and Consultation/economics/ethics/legislation & jurisprudence
MH  - Research Design/legislation & jurisprudence
MH  - Thoracic Surgery/*economics/*ethics/legislation & jurisprudence
MH  - United States
PMC - PMC4481868
MID - NIHMS327694
EDAT- 2011/08/02 06:00
MHDA- 2011/10/08 06:00
CRDT- 2011/08/02 06:00
PHST- 2011/05/19 00:00 [received]
PHST- 2011/05/19 00:00 [revised]
PHST- 2011/05/19 00:00 [accepted]
PHST- 2011/08/02 06:00 [entrez]
PHST- 2011/08/02 06:00 [pubmed]
PHST- 2011/10/08 06:00 [medline]
AID - S0003-4975(11)01314-2 [pii]
AID - 10.1016/j.athoracsur.2011.05.079 [doi]
PST - ppublish
SO  - Ann Thorac Surg. 2011 Aug;92(2):413-16. doi: 10.1016/j.athoracsur.2011.05.079.


PMID- 21801474
OWN - NLM
STAT- MEDLINE
DCOM- 20120404
LR  - 20130424
IS  - 1475-2719 (Electronic)
IS  - 0029-6651 (Linking)
VI  - 70
IP  - 4
DP  - 2011 Nov
TI  - Breast-feeding and later risk of CVD and obesity: evidence from randomised
      trials.
PG  - 472-7
LID - 10.1017/S0029665111000589 [doi]
AB  - The relationship between breast-feeding and later cardiovascular health has been 
      investigated in randomised trials and observational studies. This review focuses 
      on randomised control trials, regarded as the 'gold standard' in establishing
      causal relationships between interventions and outcomes. Since it is not ethical 
      to randomise healthy term infants to be breast- or formula-fed, only two
      randomised control trials have examined effects of breast-feeding on later
      health. In one randomised control trial, preterm infants randomised to receive
      banked donor breast milk had significantly lower blood pressure (BP), more
      favourable plasma lipid profile and reduced leptin resistance at age of 13-15
      years compared with those who were fed preterm formula; with a dose-response
      relationship between the proportion of human milk and later outcomes. In
      contrast, a cluster-randomised control trial of a breast-feeding promotion
      intervention in healthy term infants (Promotion of Breast-feeding Intervention
      Trial study) found no effect of the intervention on adiposity or BP at 6 years,
      despite increased incidence, duration and exclusivity of breast-feeding.
      Potential explanations for the discrepancy between the two studies include: (i)
      beneficial effects of breast milk on cardiovascular health might be confined to
      preterm infants; (ii) effects on cardiovascular outcomes may not manifest until
      adolescence, a concept supported by other studies; (iii) if the underlying
      mechanism for the effect of breast-feeding on later cardiovascular outcome is
      slower early growth; a concept supported by data from animal models, human
      observational studies and now experimental studies in human subjects; it is
      plausible that differences in early growth between groups in the Promotion of
      Breast-feeding Intervention Trial were insufficient to produce a detectable
      effect on these outcomes.
FAU - Fewtrell, Mary S
AU  - Fewtrell MS
AD  - Childhood Nutrition Research Centre, UCL Institute of Child Health, 30 Guilford
      Street, London WC1N 1EH, UK. m.fewtrell@ich.ucl.ac.uk
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110801
PL  - England
TA  - Proc Nutr Soc
JT  - The Proceedings of the Nutrition Society
JID - 7505881
SB  - IM
MH  - Adolescent
MH  - *Breast Feeding
MH  - Cardiovascular Diseases/*etiology/prevention & control
MH  - *Growth
MH  - Humans
MH  - *Infant Formula
MH  - *Infant Nutritional Physiological Phenomena
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Milk Banks
MH  - Milk, Human/*physiology
MH  - Obesity/*etiology
EDAT- 2011/08/02 06:00
MHDA- 2012/04/05 06:00
CRDT- 2011/08/02 06:00
PHST- 2011/08/02 06:00 [entrez]
PHST- 2011/08/02 06:00 [pubmed]
PHST- 2012/04/05 06:00 [medline]
AID - S0029665111000589 [pii]
AID - 10.1017/S0029665111000589 [doi]
PST - ppublish
SO  - Proc Nutr Soc. 2011 Nov;70(4):472-7. doi: 10.1017/S0029665111000589. Epub 2011
      Aug 1.


PMID- 21801159
OWN - NLM
STAT- MEDLINE
DCOM- 20120209
LR  - 20161125
IS  - 1365-2133 (Electronic)
IS  - 0007-0963 (Linking)
VI  - 165
IP  - 6
DP  - 2011 Dec
TI  - Oxygen saturation and perfusion changes during dermatological
      methylaminolaevulinate photodynamic therapy.
PG  - 1323-31
LID - 10.1111/j.1365-2133.2011.10554.x [doi]
AB  - BACKGROUND: Methylaminolaevulinate (MAL)-photodynamic therapy (PDT) is a
      successful topical treatment for a number of (pre)cancerous dermatological
      conditions. In combination, light of the appropriate wavelength, the
      photosensitizer protoporphyrin IX (PpIX) and tissue oxygen result in the
      production of singlet oxygen and reactive oxygen species inducing cell death.
      OBJECTIVES: This study investigates real-time changes in localized tissue blood
      oxygen saturation and perfusion in conjunction with PpIX fluorescence monitoring 
      for the first time during dermatological MAL-PDT. METHODS: Oxygen saturation,
      perfusion and PpIX fluorescence were monitored noninvasively utilizing optical
      reflectance spectroscopy, laser Doppler perfusion imaging and a fluorescence
      imaging system, respectively. Patients attending for standard dermatological
      MAL-PDT were recruited to this ethically approved study and monitored prior to,
      during and after light irradiation. RESULTS: Significant reductions in mean blood
      oxygen saturation (P < 0.005) and PpIX fluorescence (P < 0.001) were observed
      within the first minute of irradiation (4.75 J cm(-2) ) while, in contrast,
      perfusion was observed to increase significantly (P < 0.01) during treatment. The
      changes in oxygen saturation and PpIX fluorescence were positively correlated
      during the initial phase of treatment (r(2) = 0.766). CONCLUSIONS: Rapid
      reductions in the localized blood oxygen saturation have been observed for the
      first time to occur clinically within the initial minutes of light irradiation
      and positively correlate with the concurrent PpIX photobleaching. Furthermore,
      perfusion increases, suggesting that the microvasculature compensates for the
      PDT-induced oxygen depletion.
CI  - (c) 2011 The Authors. BJD (c) 2011 British Association of Dermatologists 2011.
FAU - Tyrrell, J
AU  - Tyrrell J
AD  - Clinical Photobiology, European Centre for Environment and Human Health,
      Peninsula Medical School, University of Exeter, Royal Cornwall Hospital, Truro
      TR1 3HD, UK.
FAU - Thorn, C
AU  - Thorn C
FAU - Shore, A
AU  - Shore A
FAU - Campbell, S
AU  - Campbell S
FAU - Curnow, A
AU  - Curnow A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111117
PL  - England
TA  - Br J Dermatol
JT  - The British journal of dermatology
JID - 0004041
RN  - 0 (Photosensitizing Agents)
RN  - 585NM85KYM (methyl 5-aminolevulinate)
RN  - 88755TAZ87 (Aminolevulinic Acid)
RN  - S88TT14065 (Oxygen)
SB  - IM
CIN - Br J Dermatol. 2011 Dec;165(6):1158-9. PMID: 22118554
MH  - Aged, 80 and over
MH  - Aminolevulinic Acid/*analogs & derivatives/therapeutic use
MH  - Female
MH  - Humans
MH  - Male
MH  - Microcirculation
MH  - Oxygen/*blood
MH  - Photochemotherapy/*methods
MH  - Photosensitizing Agents/*therapeutic use
MH  - Skin/blood supply
MH  - Skin Diseases/blood/*drug therapy
MH  - Skin Temperature/physiology
EDAT- 2011/08/02 06:00
MHDA- 2012/02/10 06:00
CRDT- 2011/08/02 06:00
PHST- 2011/08/02 06:00 [entrez]
PHST- 2011/08/02 06:00 [pubmed]
PHST- 2012/02/10 06:00 [medline]
AID - 10.1111/j.1365-2133.2011.10554.x [doi]
PST - ppublish
SO  - Br J Dermatol. 2011 Dec;165(6):1323-31. doi: 10.1111/j.1365-2133.2011.10554.x.
      Epub 2011 Nov 17.


PMID- 21801046
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20151119
IS  - 1943-569X (Electronic)
IS  - 0003-1488 (Linking)
VI  - 239
IP  - 3
DP  - 2011 Aug 1
TI  - Gender differences in salary and practice ownership expectations of matriculating
      veterinary students.
PG  - 329-34
LID - 10.2460/javma.239.3.329 [doi]
AB  - OBJECTIVE: To examine gender differences in initial and long-term salary and
      practice ownership expectations among first-year veterinary students. DESIGN:
      Survey. SAMPLE: First-year veterinary students at the North Carolina State
      University College of Veterinary Medicine during 2000 through 2003 and 2005
      through 2009. PROCEDURES: A 1-page survey was distributed to students during
      orientation exercises or on the first day of a first-year course on ethics and
      jurisprudence. Students were asked to indicate their expected salary at
      graduation and in 5-year increments after graduation and to indicate whether they
      expected to own a practice after graduation. RESULTS: Responses were obtained
      from 567 female and 120 male students. There was no significant difference in
      initial salary expectations between male and female students. However, men had
      higher expectations for salary increases over the course of their career, so that
      expected salary was significantly higher for men than for women 5 years after
      graduation and beyond. A significantly greater percentage of men (69/93 [74.2%]) 
      than women (242/499 [48.5%]) indicated they expected to own a practice.
      CONCLUSIONS AND CLINICAL RELEVANCE: Although male and female veterinary students 
      had similar expectations with regard to initial salaries, the male students had
      higher long-term salary expectations and were more likely to indicate an
      expectation to become a practice owner. Differences in expectations may lead to
      differences in behavior when those expectations are or are not met.
FAU - Bristol, David G
AU  - Bristol DG
AD  - Department of Clinical Sciences, College of Veterinary Medicine, North Carolina
      State University, Raleigh, NC 27606, USA. david_bristol@ncsu.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Vet Med Assoc
JT  - Journal of the American Veterinary Medical Association
JID - 7503067
SB  - IM
MH  - Attitude
MH  - Career Choice
MH  - Data Collection
MH  - Female
MH  - Humans
MH  - Job Satisfaction
MH  - Male
MH  - *Ownership
MH  - *Salaries and Fringe Benefits
MH  - *Sex Factors
MH  - Students/*psychology
MH  - Surveys and Questionnaires
MH  - Veterinarians/*psychology
MH  - Veterinary Medicine
EDAT- 2011/08/02 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/08/02 06:00
PHST- 2011/08/02 06:00 [entrez]
PHST- 2011/08/02 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.2460/javma.239.3.329 [doi]
PST - ppublish
SO  - J Am Vet Med Assoc. 2011 Aug 1;239(3):329-34. doi: 10.2460/javma.239.3.329.


PMID- 21800964
OWN - NLM
STAT- MEDLINE
DCOM- 20111223
LR  - 20111102
IS  - 1933-0693 (Electronic)
IS  - 0022-3085 (Linking)
VI  - 115
IP  - 5
DP  - 2011 Nov
TI  - Decrease in proven ventriculitis by reducing the frequency of cerebrospinal fluid
      sampling from extraventricular drains.
PG  - 1040-6
LID - 10.3171/2011.6.JNS11167 [doi]
AB  - OBJECT: Ventriculitis associated with extraventricular drains (EVD) increases
      rates of morbidity and mortality as well as costs. Surveillance samples of CSF
      are taken routinely from EVD, but there is no consensus on the optimum frequency 
      of sampling. The goal of this study was to assess whether the incidence of
      ventriculitis changed when CSF sampling frequency was reduced once every 3 days. 
      METHODS: After receiving institutional ethics committee approval for their
      project, the authors compared a prospective sample of EVD-treated patients
      (admitted 2008-2009) and a historical comparison group (admitted 2005-2007) at
      two tertiary hospital ICUs. A broad definition of ventriculitis included
      suspected ventriculitis (that is, treated with antibiotics for ventriculitis) and
      proven ventriculitis (positive CSF culture). Adult ICU patients with no
      preexisting neurological infection were enrolled in the study. After staff was
      provided with an education package, sampling of CSF was changed from daily to
      once every 3 days. All other management of the EVD remained unchanged. More
      frequent sampling was permitted if clinically indicated during the third daily
      sampling phase. RESULTS: Two hundred seven patients were recruited during the
      daily sampling phase and 176 patients when sampling was reduced to once every 3
      days. The Acute Physiology and Chronic Health Evaluation (APACHE) II score was
      lower for the daily sampling group than for the every-3rd-day group (18.6 vs
      20.3, respectively; p < 0.01), but there was no difference in mean age (47 and 45
      years, respectively; p = 0.14), male or female sex (61% and 59%, respectively; p 
      = 0.68), or median EVD duration in the ICU (4.9 and 5.8 days, respectively; p =
      0.14). Most patients were admitted with subarachnoid hemorrhage (42% in the daily
      group and 33% in the every-3rd-day group) or traumatic head injuries (29% and
      36%, respectively). The incidence of ventriculitis decreased from 17% to 11%
      overall and for proven ventriculitis from 10% to 3% once sampling frequency was
      reduced. Sampling of CSF once every 3 days was independently associated with
      ventriculitis (OR 0.44, 95% CI 0.22-0.88, p = 0.02). CONCLUSIONS: Reducing the
      frequency of CSF sampling to once every 3 days was associated with a significant 
      decrease in the incidence of ventriculitis. The authors suggest that CSF sampling
      should therefore be performed once every 3 days in the absence of clinical
      indicators of ventriculitis. Reducing frequency of CSF sampling from EVDs
      decreased proven ventriculitis.
FAU - Williams, Teresa A
AU  - Williams TA
AD  - Discipline of Emergency Medicine, School of Primary, Aboriginal and Rural Health 
      Care, Nedlands, Australia. teresa.williams@uwa.edu.au
FAU - Leslie, Gavin D
AU  - Leslie GD
FAU - Dobb, Geoffrey J
AU  - Dobb GJ
FAU - Roberts, Brigit
AU  - Roberts B
FAU - van Heerden, Peter Vernon
AU  - van Heerden PV
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110729
PL  - United States
TA  - J Neurosurg
JT  - Journal of neurosurgery
JID - 0253357
SB  - IM
CIN - J Neurosurg. 2011 Nov;115(5):1038-9; author reply 1039. PMID: 21800961
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cerebral Ventriculitis/etiology/*prevention & control
MH  - Drainage/*adverse effects
MH  - Female
MH  - Humans
MH  - Hydrocephalus/*surgery
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Ventriculostomy/*adverse effects
EDAT- 2011/08/02 06:00
MHDA- 2011/12/24 06:00
CRDT- 2011/08/02 06:00
PHST- 2011/08/02 06:00 [entrez]
PHST- 2011/08/02 06:00 [pubmed]
PHST- 2011/12/24 06:00 [medline]
AID - 10.3171/2011.6.JNS11167 [doi]
PST - ppublish
SO  - J Neurosurg. 2011 Nov;115(5):1040-6. doi: 10.3171/2011.6.JNS11167. Epub 2011 Jul 
      29.


PMID- 21800639
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20110801
IS  - 0297-2964 (Print)
IS  - 0297-2964 (Linking)
IP  - 105
DP  - 2011 Jun
TI  - [Quantitative and qualitative research methods, can they coexist yet?].
PG  - 25-30
AB  - Qualitative design is gaining ground in Nursing research. In spite of a relative 
      progress however, the evidence based practice movement continues to dominate and 
      to underline the exclusive value of quantitative design (particularly that of
      randomized clinical trials) for clinical decision making. In the actual context
      convenient to those in power making utilitarian decisions on one hand, and facing
      nursing criticism of the establishment in favor of qualitative research on the
      other hand, it is difficult to chose a practical and ethical path that values the
      nursing role within the health care system, keeping us committed to quality care 
      and maintaining researcher's integrity. Both qualitative and quantitative methods
      have advantages and disadvantages, and clearly, none of them can, by itself,
      capture, describe and explain reality adequately. Therefore, a balance between
      the two methods is needed. Researchers bare responsibility to society and
      science, and they should opt for the appropriate design susceptible to answering 
      the research question, not promote the design favored by the research funding
      distributors.
FAU - Hunt, Elena
AU  - Hunt E
AD  - Universite Laurentienne, Sudbury, Ontario, Canada. epopiea@laurentian.ca
FAU - Lavoie, Anne-Marise
AU  - Lavoie AM
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Les methodes de recherche quantitatives et qualitatives peuvent-elles deja
      coexister?
PL  - France
TA  - Rech Soins Infirm
JT  - Recherche en soins infirmiers
JID - 9715370
MH  - Humans
MH  - *Qualitative Research
MH  - *Research Design
EDAT- 2011/08/02 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/08/02 06:00
PHST- 2011/08/02 06:00 [entrez]
PHST- 2011/08/02 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
PST - ppublish
SO  - Rech Soins Infirm. 2011 Jun;(105):25-30.


PMID- 21800637
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20110801
IS  - 0297-2964 (Print)
IS  - 0297-2964 (Linking)
IP  - 105
DP  - 2011 Jun
TI  - [Well treatment and ethics of care. Similarities and differences concerning the
      scientific review].
PG  - 4-13
AB  - Neologism or new concept, the term "bientraitance" in french appeared
      historically in the disciplinary field of childhood and geriatrics. Difficult to 
      translate in the Anglo-American language, this word does not present a
      theoretical approach and a precise conceptual modeling. Use the term
      "bientraitance" in opposition with the term "maltreatment" seems reducing the
      notion. Therefore how to translate accurately the notion of "bientraitance"?
      Approach etymological, historical, philosophical in a phenomenological
      perspective can help us understand the concept. The object "bientraitance" will
      be suspected under the angle of care, caring and ethic of care. This article is
      structured around three questions: --What is "Bientraitance"? --What is the
      ethics of care? --What are the similarities and differences? In fine, we will
      demonstrate that the term of Bientraitance is a cultural consciousness about the 
      professional attitudes (listening, empathy, care) and the professional praxis
      (each act of care centred about others).
FAU - Peoc'h, Nadia
AU  - Peoc'h N
AD  - Cadre superieur de sante, CHU de Toulouse, Universite de Toulouse 2, Le Mirail.
      peoch.n@chu-toulouse.fr
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Bientraitance et ethique du care.... Similitudes et differences autour d'une
      recension des ecrits scientifiques.
PL  - France
TA  - Rech Soins Infirm
JT  - Recherche en soins infirmiers
JID - 9715370
MH  - *Ethics, Medical
MH  - Humans
MH  - *Philosophy, Medical
MH  - Physician-Patient Relations
EDAT- 2011/08/02 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/08/02 06:00
PHST- 2011/08/02 06:00 [entrez]
PHST- 2011/08/02 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
PST - ppublish
SO  - Rech Soins Infirm. 2011 Jun;(105):4-13.


PMID- 21800492
OWN - NLM
STAT- MEDLINE
DCOM- 20110811
LR  - 20110801
IS  - 0017-7768 (Print)
IS  - 0017-7768 (Linking)
VI  - 150
IP  - 6
DP  - 2011 Jun
TI  - [New possibilities resulting from oocyte banking].
PG  - 524-7, 551
AB  - Oocyte cryopreservation solves the legal and ethical problems associated with the
      cryopreservation of embryos in patients undergoing in vitro fertilization
      procedures. Furthermore, it may also offer the possibility of extending the
      reproductive capability of young women with malignant diseases in cases where the
      treatment may compromise the ovarian reserve. Moreover, it may also offer
      alternatives for infertile patients who are subject to ovarian hyper-stimulation 
      syndrome or premature ovarian faiLure or who require oocyte donation. The
      creation of banks for cryopreserved oocytes avoids the need for cycle
      synchronization or the formation of an over-supply of embryos destined for
      cryopreservation. If a Large number of oocytes is obtained it could possibly
      enable women and couples the opportunity to postpone childbirth according to
      their wishes. This paper reviews the revolution obtained by oocyte vitrification,
      reports on ethical issues and discusses the pros and cons of oocyte banking and
      its potential effects on society.
FAU - Revel, Ariel
AU  - Revel A
AD  - Department of Obstetrics and Gynecology, Hadassah Hebrew University.
      arielr2@hadassah.org.il
FAU - Revel, Michel
AU  - Revel M
FAU - Laufer, Neri
AU  - Laufer N
FAU - Kasher, Asa
AU  - Kasher A
LA  - heb
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Israel
TA  - Harefuah
JT  - Harefuah
JID - 0034351
SB  - IM
MH  - Cryopreservation/ethics/*methods
MH  - Female
MH  - Fertilization in Vitro/*methods
MH  - Humans
MH  - Infertility, Female/etiology
MH  - Neoplasms/complications/therapy
MH  - *Oocytes
MH  - Ovarian Diseases/etiology/pathology
MH  - Pregnancy
MH  - Tissue Banks
MH  - Vitrification
EDAT- 2011/08/02 06:00
MHDA- 2011/08/13 06:00
CRDT- 2011/08/02 06:00
PHST- 2011/08/02 06:00 [entrez]
PHST- 2011/08/02 06:00 [pubmed]
PHST- 2011/08/13 06:00 [medline]
PST - ppublish
SO  - Harefuah. 2011 Jun;150(6):524-7, 551.


PMID- 21800474
OWN - NLM
STAT- MEDLINE
DCOM- 20110823
LR  - 20110801
IS  - 0017-8012 (Print)
IS  - 0017-8012 (Linking)
VI  - 89
IP  - 7-8
DP  - 2011 Jul-Aug
TI  - Building collaborative enterprise.
PG  - 94-101, 164
AB  - Can large companies be both innovative and efficient? Yes, argue Adler, of the
      University of Southern California; Heckscher, of Rutgers; and Prusak, an
      independent consultant. But they must develop new organizational capabilities
      that will create the atmosphere of trust that knowledge work requires--and the
      coordinating mechanisms to make it scalable. Specifically, such organizations
      must learn to: Define a shared purpose that guides what people at all levels of
      the organization are trying to achieve together; Cultivate an ethic of
      contribution in which the highest value is accorded to people who look beyond
      their specific roles and advance the common purpose; Develop scalable procedures 
      for coordinating people's efforts so that process-management activities become
      truly interdependent; and Create an infrastructure in which individuals' spheres 
      of influence overlap and collaboration is both valued and rewarded. These four
      goals may sound idealized, but the imperative to achieve them is practical, say
      the authors. Only the truly collaborative enterprises that can tap into
      everyone's ideas---in an organized way--will compete imaginatively, quickly, and 
      cost-effectively enough to become the household names of this century.
FAU - Adler, Paul
AU  - Adler P
AD  - Marshall School of Business, University of Southern California, USA.
FAU - Heckscher, Charles
AU  - Heckscher C
FAU - Prusak, Laurence
AU  - Prusak L
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Harv Bus Rev
JT  - Harvard business review
JID - 9875796
MH  - Administrative Personnel
MH  - *Cooperative Behavior
MH  - Humans
MH  - *Leadership
MH  - *Organizational Culture
MH  - Organizational Innovation
MH  - United States
EDAT- 2011/08/02 06:00
MHDA- 2011/08/24 06:00
CRDT- 2011/08/02 06:00
PHST- 2011/08/02 06:00 [entrez]
PHST- 2011/08/02 06:00 [pubmed]
PHST- 2011/08/24 06:00 [medline]
PST - ppublish
SO  - Harv Bus Rev. 2011 Jul-Aug;89(7-8):94-101, 164.


PMID- 21800459
OWN - HMD
STAT- MEDLINE
DCOM- 20110930
LR  - 20191112
IS  - 0952-6951 (Print)
IS  - 0952-6951 (Linking)
VI  - 24
IP  - 2
DP  - 2011
TI  - Crackpots and basket-cases: a history of therapeutic work and occupation.
PG  - 65-81
AB  - Despite the long history of beliefs about the therapeutic properties of work for 
      people with mental ill health, rarely has therapeutic work itself been a focus
      for historical analysis. In this article, the development of a therapeutic work
      ethic (1813-1979) is presented, drawing particular attention to the changing
      character and quality of beliefs about therapeutic work throughout time. From
      hospital factories to radical "anti-psychiatric" communities, the article reveals
      the myriad forms of activities that have variously been considered fit work for
      people with mental health problems. While popular stereotypes of basket-weaving
      paint a hapless portrait of institutional work, a more nuanced reading of
      therapeutic work and its political and philosophical commitments is advanced. The
      article concludes by arguing that the non-linear and inherently contested
      development of therapeutic work is less the effect of paradigmatic shifts within 
      the therapeutic professions, but rather evidence of a broader human struggle with
      work.
FAU - Laws, Jennifer
AU  - Laws J
AD  - Durham Univ., UK.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - England
TA  - Hist Human Sci
JT  - History of the human sciences
JID - 100967737
MH  - History, 19th Century
MH  - History, 20th Century
MH  - Institutionalization/history
MH  - *Mental Disorders/ethnology/history
MH  - *Mentally Ill Persons/history/psychology
MH  - *Occupational Therapy/education/history
MH  - *Psychiatry/education/history
MH  - Therapeutics/history
MH  - *Work/history/physiology/psychology
EDAT- 2011/08/02 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/08/02 06:00
PHST- 2011/08/02 06:00 [entrez]
PHST- 2011/08/02 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - 10.1177/0952695111399677 [doi]
PST - ppublish
SO  - Hist Human Sci. 2011;24(2):65-81. doi: 10.1177/0952695111399677.


PMID- 25473384
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220419
IS  - 1573-4048 (Print)
IS  - 1573-4048 (Linking)
VI  - 7
IP  - 3
DP  - 2011 Aug
TI  - The Newborn Individualized Developmental Care and Assessment Program (NIDCAP)
      with Kangaroo Mother Care (KMC): Comprehensive Care for Preterm Infants.
PG  - 288-301
AB  - State-of-the-art Newborn Intensive Care Units (NICUs), instrumental in the
      survival of high-risk and ever-earlier-born preterm infants, often have costly
      human repercussions. The developmental sequelae of newborn intensive care are
      largely misunderstood. Developed countries eager to export their technologies
      must also transfer the knowledge-base that encompasses all high-risk and preterm 
      infants' personhood as well as the neuro-essential importance of their parents.
      Without such understanding, the best medical care, while assuring survival
      jeopardizes infants' long-term potential and deprives parents of their critical
      role. Exchanging the womb for the NICU environment at a time of rapid brain
      growth compromises preterm infants' early development, which results in long-term
      physical and mental health problems and developmental disabilities. The Newborn
      Individualized Developmental Care and Assessment Program (NIDCAP) aims to prevent
      the iatrogenic sequelae of intensive care and to maintain the intimate connection
      between parent and infant, one expression of which is Kangaroo Mother Care.
      NIDCAP embeds the infant in the natural parent niche, avoids over-stimulation,
      stress, pain, and isolation while it supports self-regulation, competence, and
      goal orientation. Research demonstrates that NIDCAP improves brain development,
      functional competence, health, and life quality. It is cost effective, humane,
      and ethical, and promises to become the standard for all NICU care.
FAU - Als, Heidelise
AU  - Als H
AD  - Department of Psychiatry, Harvard Medical School, and Neurobehavioral Infant and 
      Child Studies, Department of Psychiatry (Psychology) Children's Hospital Boston.
FAU - McAnulty, Gloria B
AU  - McAnulty GB
AD  - Department of Psychiatry, Harvard Medical School, and Neurobehavioral Infant and 
      Child Studies, Department of Psychiatry (Psychology) Children's Hospital Boston.
LA  - eng
GR  - P30 HD018655/HD/NICHD NIH HHS/United States
GR  - R01 HD038261/HD/NICHD NIH HHS/United States
GR  - R01 HD046855/HD/NICHD NIH HHS/United States
PT  - Journal Article
PL  - United Arab Emirates
TA  - Curr Womens Health Rev
JT  - Current women's health reviews
JID - 101240302
PMC - PMC4248304
MID - NIHMS596642
OTO - NOTNLM
OT  - Kangaroo Mother Care
OT  - NICU
OT  - NIDCAP
OT  - developmental care
OT  - premature infant
OT  - prematurity
EDAT- 2011/08/01 00:00
MHDA- 2011/08/01 00:01
CRDT- 2014/12/05 06:00
PHST- 2014/12/05 06:00 [entrez]
PHST- 2011/08/01 00:00 [pubmed]
PHST- 2011/08/01 00:01 [medline]
AID - 10.2174/157340411796355216 [doi]
PST - ppublish
SO  - Curr Womens Health Rev. 2011 Aug;7(3):288-301. doi: 10.2174/157340411796355216.


PMID- 23198471
OWN - NLM
STAT- MEDLINE
DCOM- 20130108
LR  - 20121203
IS  - 1029-4864 (Print)
IS  - 1029-4864 (Linking)
VI  - 66
IP  - 7
DP  - 2011 Aug
TI  - Dental ethics case 14. I have been offered money to enrol patients for a clinical
      research trial...
PG  - 346-7
FAU - Naidoo, S
AU  - Naidoo S
AD  - Department of Community Oral Health, University of the Western Cape, Private Bag 
      X1, Tygerberg, 7505. suenaidoo@uwc.ac.za
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - SADJ
JT  - SADJ : journal of the South African Dental Association = tydskrif van die
      Suid-Afrikaanse Tandheelkundige Vereniging
JID - 9812497
MH  - Clinical Trials as Topic/*ethics
MH  - Conflict of Interest
MH  - Dentists/*ethics
MH  - *Ethics, Dental
MH  - *Ethics, Research
MH  - Humans
MH  - Informed Consent/ethics
MH  - Motivation/*ethics
EDAT- 2011/08/01 00:00
MHDA- 2013/01/09 06:00
CRDT- 2012/12/04 06:00
PHST- 2012/12/04 06:00 [entrez]
PHST- 2011/08/01 00:00 [pubmed]
PHST- 2013/01/09 06:00 [medline]
PST - ppublish
SO  - SADJ. 2011 Aug;66(7):346-7.


PMID- 21800367
OWN - NLM
STAT- MEDLINE
DCOM- 20120628
LR  - 20140513
IS  - 1098-2353 (Electronic)
IS  - 0897-3806 (Linking)
VI  - 25
IP  - 2
DP  - 2012 Mar
TI  - Anatomy's use of unclaimed bodies: reasons against continued dependence on an
      ethically dubious practice.
PG  - 246-54
LID - 10.1002/ca.21223 [doi]
AB  - The use of unclaimed bodies has been one of the distinguishing features of the
      anatomy profession since the passing of nineteenth century legislation aimed at
      solving the problem of grave robbing. Only in more recent years has the use of
      bequeathed bodies supplanted dependence upon unclaimed bodies in many (but not
      all) countries. We argue that this dependence has opened the profession to a
      range of questionable ethical practices. Starting with contraventions of the
      early Anatomy Acts, we trace the manner in which the legitimacy of using
      unclaimed bodies has exposed vulnerable groups to dissection without their
      consent. These groups have included the impoverished, the mentally ill, African
      Americans, slaves, and stigmatized groups during the Nazi era. Unfortunately,
      ethical constraints have not been imposed on the use of unclaimed bodies. The
      major public plastination exhibitions of recent years invite us to revisit these 
      issues, even though some like Body Worlds claim to use bequeathed bodies. The
      widespread use of unclaimed bodies in institutional settings has lent to these
      public exhibitions a modicum of legitimacy that is needed even when donated
      bodies are employed. This is because the notion of donation has changed as
      demonstrated by consideration of the principles of beneficence and
      non-maleficence. We conclude that anatomists should cease using unclaimed bodies.
      Difficult as this will be in some cultures, the challenge for anatomists is to
      establish relationships of trust with their local communities and show how body
      donation can assist both the community and the profession.
CI  - Copyright (c) 2011 Wiley-Liss, Inc.
FAU - Jones, D Gareth
AU  - Jones DG
AD  - Bioethics Centre, University of Otago, Dunedin, New Zealand.
      gareth.jones@otago.ac.nz
FAU - Whitaker, Maja I
AU  - Whitaker MI
LA  - eng
PT  - Journal Article
DEP - 20110728
PL  - United States
TA  - Clin Anat
JT  - Clinical anatomy (New York, N.Y.)
JID - 8809128
SB  - IM
CIN - Clin Anat. 2014 May;27(4):512-3. PMID: 24634312
MH  - Anatomy/*education/*ethics
MH  - Cadaver
MH  - Dissection/*ethics
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Patient Rights/*ethics
MH  - Tissue Donors/*ethics
EDAT- 2011/07/30 06:00
MHDA- 2012/06/29 06:00
CRDT- 2011/07/30 06:00
PHST- 2011/03/16 00:00 [received]
PHST- 2011/05/16 00:00 [revised]
PHST- 2011/05/24 00:00 [accepted]
PHST- 2011/07/30 06:00 [entrez]
PHST- 2011/07/30 06:00 [pubmed]
PHST- 2012/06/29 06:00 [medline]
AID - 10.1002/ca.21223 [doi]
PST - ppublish
SO  - Clin Anat. 2012 Mar;25(2):246-54. doi: 10.1002/ca.21223. Epub 2011 Jul 28.


PMID- 21800211
OWN - NLM
STAT- MEDLINE
DCOM- 20120611
LR  - 20220321
IS  - 1496-8975 (Electronic)
IS  - 0832-610X (Linking)
VI  - 58
IP  - 9
DP  - 2011 Sep
TI  - Update to readers and authors on ethical and scientific misconduct: retraction of
      the "Boldt articles".
PG  - 777-9, 779-81
LID - 10.1007/s12630-011-9558-7 [doi]
FAU - Miller, Donald R
AU  - Miller DR
LA  - eng
LA  - fre
PT  - Editorial
DEP - 20110729
PL  - United States
TA  - Can J Anaesth
JT  - Canadian journal of anaesthesia = Journal canadien d'anesthesie
JID - 8701709
SB  - IM
CIN - Can J Anaesth. 2012 Dec;59(12):1089-94. PMID: 23188691
MH  - Biomedical Research/ethics/standards
MH  - Editorial Policies
MH  - *Ethics, Research
MH  - Humans
MH  - Periodicals as Topic/standards
MH  - Publishing/standards
MH  - *Retraction of Publication as Topic
MH  - *Scientific Misconduct
EDAT- 2011/07/30 06:00
MHDA- 2012/06/12 06:00
CRDT- 2011/07/30 06:00
PHST- 2011/06/22 00:00 [received]
PHST- 2011/06/30 00:00 [accepted]
PHST- 2011/07/30 06:00 [entrez]
PHST- 2011/07/30 06:00 [pubmed]
PHST- 2012/06/12 06:00 [medline]
AID - 10.1007/s12630-011-9558-7 [doi]
PST - ppublish
SO  - Can J Anaesth. 2011 Sep;58(9):777-9, 779-81. doi: 10.1007/s12630-011-9558-7. Epub
      2011 Jul 29.


PMID- 21800172
OWN - NLM
STAT- MEDLINE
DCOM- 20140714
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 4
DP  - 2013 Dec
TI  - Student-inspired activities for the teaching and learning of engineering ethics.
PG  - 1455-68
LID - 10.1007/s11948-011-9297-8 [doi]
AB  - Ethics teaching in engineering can be problematic because of student perceptions 
      of its subjective, ambiguous and philosophical content. The use of
      discipline-specific case studies has helped to address such perceptions, as has
      practical decision making and problem solving approaches based on some ethical
      frameworks. However, a need exists for a wider range of creative methods in
      ethics education to help complement the variety of activities and learning
      experiences within the engineering curriculum. In this work, a novel approach is 
      presented in which first-year undergraduate students are responsible for
      proposing ethics education activities of relevance to their peers and discipline 
      area. The students are prepared for the task through a short introduction on
      engineering ethics, whereby generic frameworks for moral and professional conduct
      are discussed, and discipline and student-relevance contexts provided. The
      approach has been used in four departments of engineering at Imperial College
      London, and has led to the generation of many creative ideas for wider student
      engagement in ethics awareness, reflection and understanding. The paper presents 
      information on the premise of the introductory sessions for supporting the design
      task, and an evaluation of the student experience of the course and task work.
      Examples of proposals are given to demonstrate the value of such an approach to
      teachers, and ultimately to the learning experiences of the students themselves.
FAU - Alpay, E
AU  - Alpay E
AD  - Faculty of Engineering, Imperial College London, Rm 2.08, Faculty Building, South
      Kensington Campus, London, SW7 2AZ, UK, e.alpay@imperial.ac.uk.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110729
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
CIN - Sci Eng Ethics. 2013 Dec;19(4):1469-72. PMID: 24178627
MH  - *Curriculum
MH  - Engineering/education/*ethics
MH  - Ethics, Professional/*education
MH  - Humans
MH  - London
MH  - Mental Processes
MH  - *Problem-Based Learning
MH  - Science/education/*ethics
MH  - *Students
MH  - *Teaching
MH  - Universities
EDAT- 2011/07/30 06:00
MHDA- 2014/07/16 06:00
CRDT- 2011/07/30 06:00
PHST- 2011/05/10 00:00 [received]
PHST- 2011/07/15 00:00 [accepted]
PHST- 2011/07/30 06:00 [entrez]
PHST- 2011/07/30 06:00 [pubmed]
PHST- 2014/07/16 06:00 [medline]
AID - 10.1007/s11948-011-9297-8 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Dec;19(4):1455-68. doi: 10.1007/s11948-011-9297-8. Epub 2011
      Jul 29.


PMID- 21800171
OWN - NLM
STAT- MEDLINE
DCOM- 20131126
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 1
DP  - 2013 Mar
TI  - Predicting the long-term effects of human-robot interaction: a reflection on
      responsibility in medical robotics.
PG  - 139-60
LID - 10.1007/s11948-011-9301-3 [doi]
AB  - This article addresses prospective and retrospective responsibility issues
      connected with medical robotics. It will be suggested that extant conceptual and 
      legal frameworks are sufficient to address and properly settle most retrospective
      responsibility problems arising in connection with injuries caused by robot
      behaviours (which will be exemplified here by reference to harms occurred in
      surgical interventions supported by the Da Vinci robot, reported in the
      scientific literature and in the press). In addition, it will be pointed out that
      many prospective responsibility issues connected with medical robotics are
      nothing but well-known robotics engineering problems in disguise, which are
      routinely addressed by roboticists as part of their research and development
      activities: for this reason they do not raise particularly novel ethical issues. 
      In contrast with this, it will be pointed out that novel and challenging
      prospective responsibility issues may emerge in connection with harmful events
      caused by normal robot behaviours. This point will be illustrated here in
      connection with the rehabilitation robot Lokomat.
FAU - Datteri, Edoardo
AU  - Datteri E
AD  - Dipartimento di Scienze Umane per la Formazione R. Massa, Universita degli Studi 
      di Milano-Bicocca, Milan, Italy. edoardo.datteri@unimib.it
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20110729
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Behavior
MH  - Engineering/*ethics
MH  - Equipment Design/*ethics
MH  - Humans
MH  - Male
MH  - Robotics/*ethics
MH  - *Social Responsibility
MH  - Time
MH  - Wounds and Injuries/*etiology
EDAT- 2011/07/30 06:00
MHDA- 2013/12/16 06:00
CRDT- 2011/07/30 06:00
PHST- 2011/02/12 00:00 [received]
PHST- 2011/07/19 00:00 [accepted]
PHST- 2011/07/30 06:00 [entrez]
PHST- 2011/07/30 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1007/s11948-011-9301-3 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Mar;19(1):139-60. doi: 10.1007/s11948-011-9301-3. Epub 2011 
      Jul 29.


PMID- 21800141
OWN - NLM
STAT- MEDLINE
DCOM- 20120131
LR  - 20211020
IS  - 1437-9813 (Electronic)
IS  - 0179-0358 (Linking)
VI  - 27
IP  - 10
DP  - 2011 Oct
TI  - Immunohistochemical confirmation of the presence of smooth muscle in the normal
      neonatal anorectum and in neonates with anorectal malformations.
PG  - 1069-74
LID - 10.1007/s00383-011-2952-y [doi]
AB  - AIM: To evaluate the presence of smooth muscle in relation to the anorectum in
      neonates that are normal and in neonates with anorectal malformations using
      immunohistochemical staining of antibodies specific to smooth muscle actin (SMA).
      METHODS: Research ethics committee approval was obtained to study historical
      neonatal tissue sections. 7-15-mu thickness, sagittal sections of both normal
      anorectums (NA) and neonates with anorectal malformations (ARM) were available to
      study. The fragile tissue predates the development of charged glass microscope
      slides that are inherent to contemporary immunohistochemistry (IHC). Normal
      appendix sections on non-charged slides were used to establish and optimise a
      novel, steam generated heat, antigen retrieval protocol. This technique of
      "gentle" antigen retrieval allows preservation of tissue architecture whilst
      maintaining adequate staining of tissue on non-charged glass microscope slides.
      NA and ARM tissue was stained and compared to control NA and ARM sections.
      RESULTS: SMA staining was observed in sagittal sections of both normal neonatal
      anorectums and neonates with anorectal malformations, confirming the presence of 
      smooth muscle. CONCLUSION: This preliminary work confirms the presence of smooth 
      muscle in the anorectum of neonates that are normal and in neonates with
      anorectal malformations. It is likely that the smooth muscle complex demonstrated
      represents the internal anal sphincter in the normal anorectum. It is postulated 
      that the smooth muscle complex seen in anorectal malformations may represent a
      similar internal anal sphincter complex which maybe of functional significance.
      Further IHC of tissue sections will allow reconstruction of the exact
      three-dimensional smooth muscle structure of the anorectum in neonates that are
      normal and neonates with anorectal malformations.
FAU - Cleeve, Stewart
AU  - Cleeve S
AD  - Department of Paediatric Surgery, Barts and The London Children's Hospital,
      Whitechapel, London, E1 1BB, UK. stewart.cleeve@bartsandthelondon.nhs.uk
FAU - Lawson, Jeremy
AU  - Lawson J
FAU - Martin, Joanne
AU  - Martin J
FAU - Ward, Harry
AU  - Ward H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Germany
TA  - Pediatr Surg Int
JT  - Pediatric surgery international
JID - 8609169
RN  - 0 (Actins)
SB  - IM
MH  - Actins/*metabolism
MH  - Anal Canal/*anatomy & histology/pathology
MH  - Anorectal Malformations
MH  - Anus, Imperforate/*pathology
MH  - Case-Control Studies
MH  - Fluorescent Antibody Technique/methods
MH  - Humans
MH  - Infant, Newborn
MH  - London
MH  - Muscle, Smooth/*anatomy & histology/pathology
MH  - Staining and Labeling/methods
MH  - Tissue Preservation
EDAT- 2011/07/30 06:00
MHDA- 2012/02/01 06:00
CRDT- 2011/07/30 06:00
PHST- 2011/07/30 06:00 [entrez]
PHST- 2011/07/30 06:00 [pubmed]
PHST- 2012/02/01 06:00 [medline]
AID - 10.1007/s00383-011-2952-y [doi]
PST - ppublish
SO  - Pediatr Surg Int. 2011 Oct;27(10):1069-74. doi: 10.1007/s00383-011-2952-y.


PMID- 21800117
OWN - NLM
STAT- MEDLINE
DCOM- 20120214
LR  - 20220408
IS  - 1437-160X (Electronic)
IS  - 0172-8172 (Linking)
VI  - 31
IP  - 11
DP  - 2011 Nov
TI  - Writing a narrative biomedical review: considerations for authors, peer
      reviewers, and editors.
PG  - 1409-17
LID - 10.1007/s00296-011-1999-3 [doi]
AB  - Review articles comprehensively covering a specific topic are crucial for
      successful research and academic projects. Most editors consider review articles 
      for special and regular issues of journals. Writing a review requires deep
      knowledge and understanding of a field. The aim of this review is to analyze the 
      main steps in writing a narrative biomedical review and to consider points that
      may increase the chances of success. We performed a comprehensive search through 
      MEDLINE, EMBASE, Scopus, and Web of Science using the following keywords: review 
      of the literature, narrative review, title, abstract, authorship, ethics, peer
      review, research methods, medical writing, scientific writing, and writing
      standards. Opinions expressed in the review are also based on personal experience
      as authors, peer reviewers, and editors.
FAU - Gasparyan, Armen Yuri
AU  - Gasparyan AY
AD  - Department of Rheumatology, Clinical Research Unit, Dudley Group of Hospitals NHS
      Foundation Trust (Teaching Trust of University of Birmingham, UK), Russell's Hall
      Hospital, North Block, Dudley, West Midlands, DY1 2HQ, United Kingdom.
      a.gasparyan@gmail.com
FAU - Ayvazyan, Lilit
AU  - Ayvazyan L
FAU - Blackmore, Heather
AU  - Blackmore H
FAU - Kitas, George D
AU  - Kitas GD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110729
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
SB  - IM
MH  - Databases, Bibliographic
MH  - Humans
MH  - *Narration
MH  - *Peer Review/methods/standards
MH  - Periodicals as Topic/*standards
MH  - Publishing/*standards
MH  - *Review Literature as Topic
MH  - Writing/*standards
EDAT- 2011/07/30 06:00
MHDA- 2012/02/15 06:00
CRDT- 2011/07/30 06:00
PHST- 2011/01/02 00:00 [received]
PHST- 2011/07/10 00:00 [accepted]
PHST- 2011/07/30 06:00 [entrez]
PHST- 2011/07/30 06:00 [pubmed]
PHST- 2012/02/15 06:00 [medline]
AID - 10.1007/s00296-011-1999-3 [doi]
PST - ppublish
SO  - Rheumatol Int. 2011 Nov;31(11):1409-17. doi: 10.1007/s00296-011-1999-3. Epub 2011
      Jul 29.


PMID- 21799360
OWN - NLM
STAT- MEDLINE
DCOM- 20111005
LR  - 20110729
IS  - 1539-0721 (Electronic)
IS  - 0002-0443 (Linking)
VI  - 41
IP  - 7-8
DP  - 2011 Jul-Aug
TI  - Nursing leadership from bedside to boardroom: a Gallup national survey of opinion
      leaders.
PG  - 299-305
LID - 10.1097/NNA.0b013e3182250a0d [doi]
AB  - OBJECTIVE: : The purpose of this study was to examine how nursing is viewed by
      the nation's decision makers and opinion leaders. BACKGROUND: : Nurses comprise
      the largest subgroup of the health and healthcare workforce. The public
      recognizes nurses' contributions, consistently ranking them highest in honesty
      and ethics. Yet, significant barriers remain in nurses achieving substantial
      leadership positions in health and healthcare delivery and policy. METHODS: : The
      study sampled a broad cross section of American opinion leaders in the public and
      private sector, academia, and trade organizations. More than 1,500 opinion
      leaders were interviewed by telephone interviewers. RESULTS: : The opinion
      leaders viewed government (75%) and health insurance executives (56%) as the
      groups most likely to exert a great deal of influence on health reform, compared 
      with 14% for nurses. Government respondents were significantly different than all
      other respondents; 23% of these respondents said nurses have a great deal of
      influence in healthcare reform, compared with 14% of other individuals.
      CONCLUSION: : Although nurses are viewed as knowledgeable sources of health
      information, nurses are not viewed as leaders in the development of healthcare
      systems and delivery. The opinion leaders' survey identifies barriers to nurses
      assuming a greater leadership role, including management skills and knowledge.
FAU - Khoury, Christopher M
AU  - Khoury CM
AD  - Gallup, Inc, Washington, DC, USA.
FAU - Blizzard, Richard
AU  - Blizzard R
FAU - Wright Moore, Linda
AU  - Wright Moore L
FAU - Hassmiller, Susan
AU  - Hassmiller S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Nurs Adm
JT  - The Journal of nursing administration
JID - 1263116
SB  - IM
MH  - Cross-Sectional Studies
MH  - *Health Care Reform
MH  - Humans
MH  - *Leadership
MH  - *Nurse's Role
MH  - *Policy Making
MH  - *Public Opinion
MH  - United States
EDAT- 2011/07/30 06:00
MHDA- 2011/10/06 06:00
CRDT- 2011/07/30 06:00
PHST- 2011/07/30 06:00 [entrez]
PHST- 2011/07/30 06:00 [pubmed]
PHST- 2011/10/06 06:00 [medline]
AID - 10.1097/NNA.0b013e3182250a0d [doi]
AID - 00005110-201107000-00004 [pii]
PST - ppublish
SO  - J Nurs Adm. 2011 Jul-Aug;41(7-8):299-305. doi: 10.1097/NNA.0b013e3182250a0d.


PMID- 21798627
OWN - NLM
STAT- MEDLINE
DCOM- 20120105
LR  - 20110905
IS  - 1532-2939 (Electronic)
IS  - 0195-6701 (Linking)
VI  - 79
IP  - 2
DP  - 2011 Oct
TI  - Patient rights and healthcare-associated infection.
PG  - 99-102
LID - 10.1016/j.jhin.2011.04.031 [doi]
AB  - The Universal Declaration of Human Rights was adopted by the United Nations in
      1948, and since that time, human rights have become widely recognized and legally
      enforceable in many countries. Patient rights are now included in healthcare
      constitutions, such as that of the English National Health Service, and in
      professional codes of practice. Patient rights have a number of implications for 
      the control of healthcare-associated infections (HCAI), including: (1)
      justification for infection control over and above economic benefit; (2) focus
      and emphasis on the individual patient experience; (3) identification of some of 
      the actions taken to control infection as breaches of rights; (4) bridging
      professional, infection control and public health ethics; (5) a requirement to
      specify the conditions under which rights can be breached; and (6) grounds for
      those seeking compensation for HCAI. Assuring patient rights has the potential to
      improve the patient experience, and in so doing, improve public confidence in
      healthcare provision and providers.
CI  - Copyright (c) 2011 The Healthcare Infection Society. Published by Elsevier Ltd.
      All rights reserved.
FAU - Millar, M
AU  - Millar M
AD  - Department of Infection, Barts and The London NHS Trust, Whitechapel, London, UK.
      M.R.Millar@qmul.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20110727
PL  - England
TA  - J Hosp Infect
JT  - The Journal of hospital infection
JID - 8007166
SB  - IM
MH  - Cross Infection/*prevention & control
MH  - Delivery of Health Care/*ethics
MH  - Ethics, Medical
MH  - Human Rights
MH  - Humans
MH  - *Infection Control/legislation & jurisprudence/methods
MH  - National Health Programs/ethics
MH  - *Patient Rights
EDAT- 2011/07/30 06:00
MHDA- 2012/01/06 06:00
CRDT- 2011/07/30 06:00
PHST- 2011/03/11 00:00 [received]
PHST- 2011/04/29 00:00 [accepted]
PHST- 2011/07/30 06:00 [entrez]
PHST- 2011/07/30 06:00 [pubmed]
PHST- 2012/01/06 06:00 [medline]
AID - S0195-6701(11)00253-2 [pii]
AID - 10.1016/j.jhin.2011.04.031 [doi]
PST - ppublish
SO  - J Hosp Infect. 2011 Oct;79(2):99-102. doi: 10.1016/j.jhin.2011.04.031. Epub 2011 
      Jul 27.


PMID- 21798068
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20211020
IS  - 1472-6920 (Electronic)
IS  - 1472-6920 (Linking)
VI  - 11
DP  - 2011 Jul 29
TI  - Australian medical students' perceptions of professionalism and ethics in medical
      television programs.
PG  - 50
LID - 10.1186/1472-6920-11-50 [doi]
AB  - BACKGROUND: Medical television programs offer students fictional representations 
      of their chosen career. This study aimed to discover undergraduate medical
      students' viewing of medical television programs and students' perceptions of
      professionalism, ethics, realism and role models in the programs. The purpose was
      to consider implications for teaching strategies. METHODS: A medical television
      survey was administered to 386 undergraduate medical students across Years 1 to 4
      at a university in New South Wales, Australia. The survey collected data on
      demographics, year of course, viewing of medical television programs, perception 
      of programs' realism, depiction of ethics, professionalism and role models.
      RESULTS: The shows watched by most students were House, Scrubs, and Grey's
      Anatomy, and students nominated watching 30 different medical programs in total. 
      There was no statistical association between year of enrolment and perceptions of
      accuracy. The majority of students reported that friends or family members had
      asked them for their opinion on an ethical or medical issue presented on a
      program, and that they discussed ethical and medical matters with their friends. 
      Students had high recall of ethical topics portrayed on the shows, and most
      believed that medical programs generally portrayed ideals of professionalism
      well. CONCLUSIONS: Medical programs offer considerable currency and relevance
      with students and may be useful in teaching strategies that engage students in
      ethical lessons about practising medicine.
CI  - (c) 2011 Weaver and Wilson; licensee BioMed Central Ltd.
FAU - Weaver, Roslyn
AU  - Weaver R
AD  - Family and Community Health Research Group, University of Western Sydney,
      Narellan Road Campbelltown NSW 2560, Australia. r.weaver@uws.edu.au
FAU - Wilson, Ian
AU  - Wilson I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110729
PL  - England
TA  - BMC Med Educ
JT  - BMC medical education
JID - 101088679
SB  - IM
MH  - Australia
MH  - Data Collection
MH  - *Drama
MH  - *Ethics
MH  - Female
MH  - Humans
MH  - Male
MH  - New South Wales
MH  - *Professional Competence
MH  - Students, Medical/*psychology
MH  - Teaching/methods
MH  - *Television
MH  - Young Adult
PMC - PMC3162942
EDAT- 2011/07/30 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/30 06:00
PHST- 2011/01/19 00:00 [received]
PHST- 2011/07/29 00:00 [accepted]
PHST- 2011/07/30 06:00 [entrez]
PHST- 2011/07/30 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 1472-6920-11-50 [pii]
AID - 10.1186/1472-6920-11-50 [doi]
PST - epublish
SO  - BMC Med Educ. 2011 Jul 29;11:50. doi: 10.1186/1472-6920-11-50.


PMID- 21798048
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20220410
IS  - 1471-2431 (Electronic)
IS  - 1471-2431 (Linking)
VI  - 11
DP  - 2011 Jul 28
TI  - Paediatric UK demyelinating disease longitudinal study (PUDDLS).
PG  - 68
LID - 10.1186/1471-2431-11-68 [doi]
AB  - BACKGROUND: There is evidence that at least 5% of Multiple sclerosis (MS) cases
      manifest in childhood. Children with MS present with a demyelinating episode
      involving single or multiple symptoms prior to developing a second event (usually
      within two years) to then meet criteria for diagnosis. There is evidence from
      adult cohorts that the incidence and sex ratios of MS are changing and that
      children of immigrants have a higher risk for developing MS. A paediatric
      population should reflect the vanguard of such changes and may reflect trends yet
      to be observed in adult cohorts. Studying a paediatric population from the first 
      demyelinating event will allow us to test these hypotheses, and may offer further
      valuable insights into the genetic and environmental interactions in the
      pathogenesis of MS. METHODS/DESIGN: The Paediatric UK Demyelinating Disease
      Longitudinal Study (PUDDLS) is a prospective longitudinal observational study
      which aims to determine the natural history, predictors and outcomes of childhood
      CNS inflammatory demyelinating diseases. PUDDLS will involve centres in the UK,
      and will establish a cohort of children affected with a first CNS inflammatory
      demyelinating event for long-term follow up by recruiting for approximately 5
      years. PUDDLS will also establish a biological sample archive (CSF, serum, and
      DNA), allowing future hypothesis driven research. For example, the future
      discovery of a biomarker will allow validation within this dataset for the
      evaluation of novel biomarkers. Patients will also be requested to consent to be 
      contacted in the future. A secondary aim is to collaborate internationally with
      the International Paediatric Multiple Sclerosis Study Group when future
      collaborative studies are proposed, whilst sharing a minimal anonymised dataset. 
      PUDDLS is the second of two jointly funded studies. The first (UCID-SS) is an
      epidemiological surveillance study that already received ethical approvals, and
      started on the 1st September 2009. There is no direct patient involvement, and
      UCID-SS aims to determine the UK and Ireland incidence of CNS inflammatory
      demyelinating disorders in children under 16 years. DISCUSSION: A paediatric
      population should reflect the vanguard of MS epidemiological changes and may
      reflect trends yet to be observed in adult MS cohorts. The restricted window
      between clinical expression of disease and exposure to environmental factors in
      children offers a unique research opportunity. Studying a paediatric population
      from the first demyelinating event will allow us to investigate the changing
      epidemiology of MS, and may offer further valuable insights into the genetic and 
      environmental interactions in the pathogenesis of MS.
FAU - Absoud, Michael
AU  - Absoud M
AD  - School of Health & Population Sciences, University of Birmingham, Birmingham, UK.
      michaelabsoud@childdemyelination.org.uk
FAU - Cummins, Carole
AU  - Cummins C
FAU - Chong, Wui K
AU  - Chong WK
FAU - De Goede, Christian
AU  - De Goede C
FAU - Foster, Katharine
AU  - Foster K
FAU - Gunny, Roxanna
AU  - Gunny R
FAU - Hemingway, Cheryl
AU  - Hemingway C
FAU - Jardine, Philip
AU  - Jardine P
FAU - Kneen, Rachel
AU  - Kneen R
FAU - Likeman, Marcus
AU  - Likeman M
FAU - Lim, Ming J
AU  - Lim MJ
FAU - Pike, Mike
AU  - Pike M
FAU - Sibtain, Naomi
AU  - Sibtain N
FAU - Whitehouse, William P
AU  - Whitehouse WP
FAU - Wassmer, Evangeline
AU  - Wassmer E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110728
PL  - England
TA  - BMC Pediatr
JT  - BMC pediatrics
JID - 100967804
RN  - 0 (Biomarkers)
SB  - IM
MH  - Biomarkers/analysis
MH  - Child
MH  - Cost of Illness
MH  - Demyelinating Diseases/complications/*diagnosis/drug therapy/*physiopathology
MH  - Diagnosis, Differential
MH  - Disease Progression
MH  - Early Diagnosis
MH  - Humans
MH  - Longitudinal Studies
MH  - Multiple Sclerosis/diagnosis/drug therapy/etiology/*physiopathology
MH  - Prospective Studies
MH  - Quality of Life
MH  - United Kingdom/epidemiology
PMC - PMC3163536
EDAT- 2011/07/30 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/07/30 06:00
PHST- 2011/05/17 00:00 [received]
PHST- 2011/07/28 00:00 [accepted]
PHST- 2011/07/30 06:00 [entrez]
PHST- 2011/07/30 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - 1471-2431-11-68 [pii]
AID - 10.1186/1471-2431-11-68 [doi]
PST - epublish
SO  - BMC Pediatr. 2011 Jul 28;11:68. doi: 10.1186/1471-2431-11-68.


PMID- 21797912
OWN - NLM
STAT- MEDLINE
DCOM- 20140108
LR  - 20171116
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 27
IP  - 2
DP  - 2013 Feb
TI  - Stigmatization and public health ethics.
PG  - 74-80
LID - 10.1111/j.1467-8519.2011.01904.x [doi]
AB  - Encouraged by the success of smoking denormalization strategies as a
      tobacco-control measure, public health institutions are adopting a similar
      approach to other health behaviors. For example, a recent controversial ad
      campaign in New York explicitly aimed to denormalize HIV/AIDS amongst gay men.
      Authors such as Scott Burris have argued that efforts like this are tantamount to
      stigmatization and that such stigmatization is unethical because it is
      dehumanizing. Others have offered a limited endorsement of
      denormalization/stigmatization campaigns as being justified on consequentialist
      grounds; namely, that the potential public health benefits outweigh any
      stigmatizing side effects. In this paper, I examine and reject the blanket
      condemnation of stigmatization efforts in public health. I argue that the moral
      status of such efforts are best evaluated within a contractualist, as opposed to 
      a consequentialist, framework. Contractualism in public health ethics asks
      whether a particular stigmatizing policy could be justified to reasonable
      individuals who do not know whether they will be affected by that policy. Using
      this approach, I argue that it is sometimes permissible for public health
      institutions to engage in health-related stigmatization.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Courtwright, Andrew
AU  - Courtwright A
AD  - Massachusetts General Hospital/Harvard/Harvard Medical School, Department of
      Internal Medicine, Women's Health Associates, Boston, MA 02114, USA.
      acourtwright@partners.org
LA  - eng
PT  - Journal Article
DEP - 20110729
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Behavior Control/*ethics/methods
MH  - Dehumanization
MH  - Health Promotion/*ethics/methods
MH  - Humans
MH  - Morals
MH  - Obesity/prevention & control
MH  - Public Health Practice/*ethics
MH  - Safe Sex
MH  - Smoking Prevention
MH  - *Social Stigma
MH  - Stereotyping
MH  - United States
EDAT- 2011/07/30 06:00
MHDA- 2014/01/09 06:00
CRDT- 2011/07/30 06:00
PHST- 2011/07/30 06:00 [entrez]
PHST- 2011/07/30 06:00 [pubmed]
PHST- 2014/01/09 06:00 [medline]
AID - 10.1111/j.1467-8519.2011.01904.x [doi]
PST - ppublish
SO  - Bioethics. 2013 Feb;27(2):74-80. doi: 10.1111/j.1467-8519.2011.01904.x. Epub 2011
      Jul 29.


PMID- 21797728
OWN - NLM
STAT- MEDLINE
DCOM- 20111223
LR  - 20110729
IS  - 1465-3419 (Electronic)
IS  - 1355-7858 (Linking)
VI  - 16
IP  - 4-5
DP  - 2011 Aug-Oct
TI  - Barriers to conceiving sibling donors for sickle cell disease: perspectives from 
      patients and parents.
PG  - 431-45
LID - 10.1080/13557858.2011.558619 [doi]
AB  - OBJECTIVES: The lack of matched sibling donors poses a significant barrier to
      utilizing hematopoietic cell transplantation (HCT), the only proven cure for
      children with sickle cell disease (SCD). Little is known about current patient
      and parent perspectives towards HCT for SCD. This study examines the perceived
      barriers of transplant, and the use of in vitro fertilization (IVF) and
      preimplantation genetic diagnosis (PGD), when there is no pre-existing sibling
      donor. DESIGN: Semi-structured interviews were conducted with adult patients with
      SCD and parents of children with SCD in an urban medical center in the US.
      Transcribed data was analyzed using qualitative methods. RESULTS: Of 23
      participants, 17 reported having heard of HCT for SCD. Fewer knew of IVF or PGD
      as a means for conceiving an unaffected child (n =7) or to select a potential
      umbilical cord blood donor (n =1). The financial cost of IVF and PGD was
      perceived as a significant initial barrier to accessing these technologies, with 
      the clinical risks of HCT and the ethical appropriateness of using PGD also
      identified as barriers. The value of informing families of these options was a
      recurring theme, even among respondents who personally disagreed with their
      application. CONCLUSION: The low utilization of curative strategies for SCD
      appears to be partly attributable to a lack of information about the technologies
      available to facilitate transplantation. Ethical reservations, while present,
      were not static and did not preclude patients' and parents' desire to be
      informed. We discuss the implications of these perceived barriers to the
      dissemination of advanced medical technologies for SCD.
FAU - Jae, Gina A
AU  - Jae GA
AD  - Division of General Internal Medicine, Mount Sinai School of Medicine, 1 Gustave 
      Levy Place, New York City, NY 10029, USA. gj2008@columbia.edu
FAU - Lewkowitz, Adam K
AU  - Lewkowitz AK
FAU - Yang, Joanna C
AU  - Yang JC
FAU - Shen, Liang
AU  - Shen L
FAU - Rahman, Amal
AU  - Rahman A
FAU - Del Toro, Gustavo
AU  - Del Toro G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Ethn Health
JT  - Ethnicity & health
JID - 9608374
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anemia, Sickle Cell/*therapy
MH  - Bioethical Issues
MH  - Cytogenetic Analysis
MH  - Female
MH  - Fertilization in Vitro/*economics/ethics
MH  - Health Knowledge, Attitudes, Practice
MH  - Hematopoietic Stem Cell Transplantation/*adverse effects/economics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pregnancy
MH  - Preimplantation Diagnosis/*ethics
MH  - Severity of Illness Index
MH  - *Siblings
MH  - Social Class
MH  - Tissue Donors/*ethics/supply & distribution
MH  - Young Adult
EDAT- 2011/07/30 06:00
MHDA- 2011/12/24 06:00
CRDT- 2011/07/30 06:00
PHST- 2011/07/30 06:00 [entrez]
PHST- 2011/07/30 06:00 [pubmed]
PHST- 2011/12/24 06:00 [medline]
AID - 10.1080/13557858.2011.558619 [doi]
PST - ppublish
SO  - Ethn Health. 2011 Aug-Oct;16(4-5):431-45. doi: 10.1080/13557858.2011.558619.


PMID- 21797724
OWN - NLM
STAT- MEDLINE
DCOM- 20111223
LR  - 20211203
IS  - 1465-3419 (Electronic)
IS  - 1355-7858 (Linking)
VI  - 16
IP  - 4-5
DP  - 2011 Aug-Oct
TI  - Ethical implications and practical considerations of ethnically targeted
      screening for genetic disorders: the case of hemoglobinopathy screening.
PG  - 377-88
LID - 10.1080/13557858.2010.541902 [doi]
AB  - The prevalence of hemoglobinopathies differs among populations due to genetic
      differences and due to the protective effects of the heterozygote (carrier) state
      against malaria. Because of the difference in genetic distribution, public health
      programs have weighed the ethical versus practical implications of ethnically
      targeted versus universal newborn, and where applicable, prenatal screening. We
      examine newborn and prenatal screening for hemoglobinopathies in relation to the 
      use of 'race' and ethnicity to assess risk for genetic conditions. First,
      categories of race/ethnicity are social constructs, therefore, observed or
      self-identified broad racial/ethnic categories are correlated but not necessarily
      reliable indicators of geographic ancestry or genetic risk. Second, targeting
      based on ethnicity poses serious issues of logistics and equity for public health
      programs and clinical services. In the past, newborn screening for
      hemoglobinopathies in the United States and United Kingdom was often selective,
      targeted to women of certain ethnic groups or areas with large concentrations of 
      ethnic minority groups. Presently, newborn screening for hemoglobinopathies is
      universal in both countries and programs emphasize that individuals of all ethnic
      backgrounds are at risk for carrying a hemoglobin genetic variant. Reported
      race/ethnicity is still used as a criterion for offering prenatal carrier testing
      in the United States, where it is not a public health responsibility. In the
      United Kingdom, prenatal screening under the National Health Service is universal
      in high-prevalence areas and in low-prevalence areas is targeted based on
      reported ancestry. The continued use of targeted prenatal screening in both
      countries reflects the different purposes and modes of laboratory testing in
      newborn and prenatal screening. The ethical imperative to identify as many
      affected infants with life-threatening conditions as possible in newborn
      screening programs is not applicable to prenatal carrier testing. Because newborn
      screening dried blood spot specimens are tested for multiple disorders, targeted 
      screening poses serious logistical challenges which is not the case in prenatal
      screening.
FAU - Hinton, Cynthia F
AU  - Hinton CF
AD  - National Center on Birth Defects and Developmental Disabilities, Centers for
      Disease Control and Prevention, 1600 Clifton Rd, MS E-86, Atlanta, GA 30333, USA.
      CHinton@cdc.gov
FAU - Grant, Althea M
AU  - Grant AM
FAU - Grosse, Scott D
AU  - Grosse SD
LA  - eng
PT  - Journal Article
PL  - England
TA  - Ethn Health
JT  - Ethnicity & health
JID - 9608374
SB  - IM
MH  - Female
MH  - Genetic Testing/*ethics
MH  - Health Policy
MH  - Hemoglobinopathies/diagnosis/*ethnology/*genetics
MH  - Heterozygote
MH  - Humans
MH  - Infant, Newborn
MH  - Neonatal Screening/*ethics/methods
MH  - Prenatal Diagnosis/*ethics/methods
MH  - Racial Groups/*genetics
MH  - United Kingdom
MH  - United States
EDAT- 2011/07/30 06:00
MHDA- 2011/12/24 06:00
CRDT- 2011/07/30 06:00
PHST- 2011/07/30 06:00 [entrez]
PHST- 2011/07/30 06:00 [pubmed]
PHST- 2011/12/24 06:00 [medline]
AID - 10.1080/13557858.2010.541902 [doi]
PST - ppublish
SO  - Ethn Health. 2011 Aug-Oct;16(4-5):377-88. doi: 10.1080/13557858.2010.541902.


PMID- 21797058
OWN - NLM
STAT- MEDLINE
DCOM- 20110816
LR  - 20110729
IS  - 0549-3323 (Print)
IS  - 0549-3323 (Linking)
VI  - 57
IP  - 1
DP  - 2011 Mar
TI  - [Protection of human subjects in medical research: from the viewpoint of
      historical development of ethical regulations].
PG  - 63-70
AB  - Recent clinical research is conducted based on bioethical consideration of human 
      subjects. The Ethical Guidelines for Clinical Studies (EGCS) form the standard
      for this 'subject protection'. In current clinical research, consideration of
      subject rights and life is held more important than the scientific and social
      value of the research. We describe herein the major revisions and history of
      ethical considerations leading up to implementation of the revised EGCS on April 
      1, 2009. The obligations of clinical researchers regarding ethical studies and
      training and enrollment in insurance for subject compensation have been added to 
      these latest guidelines. The role of ethics review boards, which supervise
      whether clinical researchers are actively performing subject protection, is also 
      becoming extremely important.
FAU - Sekine, Toru
AU  - Sekine T
AD  - Department of Humanities, School of Dental Medicine, Tsurumi University.
FAU - Shimada, Michiko
AU  - Shimada M
LA  - jpn
PT  - English Abstract
PT  - Historical Article
PT  - Journal Article
PL  - Japan
TA  - Nihon Ishigaku Zasshi
JT  - Nihon ishigaku zasshi. [Journal of Japanese history of medicine]
JID - 0165261
MH  - Biomedical Research/history/*legislation & jurisprudence
MH  - Ethics, Medical/*history
MH  - Ethics, Research/*history
MH  - Guidelines as Topic
MH  - History, 19th Century
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Human Experimentation/history/*legislation & jurisprudence
MH  - Human Rights/history/legislation & jurisprudence
MH  - Humans
MH  - Japan
EDAT- 2011/07/30 06:00
MHDA- 2011/08/17 06:00
CRDT- 2011/07/30 06:00
PHST- 2011/07/30 06:00 [entrez]
PHST- 2011/07/30 06:00 [pubmed]
PHST- 2011/08/17 06:00 [medline]
PST - ppublish
SO  - Nihon Ishigaku Zasshi. 2011 Mar;57(1):63-70.


PMID- 21796744
OWN - NLM
STAT- MEDLINE
DCOM- 20120105
LR  - 20110902
IS  - 1521-3773 (Electronic)
IS  - 1433-7851 (Linking)
VI  - 50
IP  - 37
DP  - 2011 Sep 5
TI  - Ethics, chemistry, and education for sustainability.
PG  - 8482-90
LID - 10.1002/anie.201007599 [doi]
FAU - Frank, Hartmut
AU  - Frank H
AD  - Universitat Bayreuth, Hudo-Rudel-Strasse 8, 95445 Bayreuth, Germany.
      hartmut.frank@uni-bayreuth.de
FAU - Campanella, Luigi
AU  - Campanella L
FAU - Dondi, Francesco
AU  - Dondi F
FAU - Mehlich, Jan
AU  - Mehlich J
FAU - Leitner, Erich
AU  - Leitner E
FAU - Rossi, Giuseppe
AU  - Rossi G
FAU - Ndjoko Ioset, Karine
AU  - Ndjoko Ioset K
FAU - Bringmann, Gerhard
AU  - Bringmann G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110727
PL  - Germany
TA  - Angew Chem Int Ed Engl
JT  - Angewandte Chemie (International ed. in English)
JID - 0370543
SB  - IM
MH  - Animals
MH  - *Chemistry
MH  - *Conservation of Natural Resources
MH  - *Education
MH  - *Ethics
MH  - Humans
EDAT- 2011/07/29 06:00
MHDA- 2012/01/06 06:00
CRDT- 2011/07/29 06:00
PHST- 2010/12/03 00:00 [received]
PHST- 2011/04/07 00:00 [revised]
PHST- 2011/07/29 06:00 [entrez]
PHST- 2011/07/29 06:00 [pubmed]
PHST- 2012/01/06 06:00 [medline]
AID - 10.1002/anie.201007599 [doi]
PST - ppublish
SO  - Angew Chem Int Ed Engl. 2011 Sep 5;50(37):8482-90. doi: 10.1002/anie.201007599.
      Epub 2011 Jul 27.


PMID- 21796589
OWN - NLM
STAT- MEDLINE
DCOM- 20120531
LR  - 20111019
IS  - 1439-4421 (Electronic)
IS  - 0941-3790 (Linking)
VI  - 73
IP  - 10
DP  - 2011 Oct
TI  - [The Danish debate on priority setting in medicine - characteristics and
      results].
PG  - 680-7
LID - 10.1055/s-0031-1280841 [doi]
AB  - Priority setting in medicine helps to achieve a fair and transparent distribution
      of health-care resources. The German discussion about priority setting is still
      in its infancy and may benefit from other countries' experiences. This paper aims
      to analyse the Danish priority setting debate in order to stimulate the German
      discussion. The methods used are a literature analysis and a document analysis as
      well as expert interviews. The Danish debate about priority setting in medicine
      began in the 1970s, when a government committee was constituted to evaluate
      health-care priorities at the national level. In the 1980s a broader debate arose
      in politics, ethics, medicine and health economy. The discussions reached a
      climax in the 1990s, when many local activities - always involving the public -
      were initiated. Some Danish counties tried to implement priority setting in the
      daily routine of health care. The Council of Ethics was a major player in the
      debate of the 1990s and published a detailed statement on priority setting in
      1996. With the new century the debate about priority setting seemed to have come 
      to an end, but in 2006 the Technology Council and the Danish Regions resumed the 
      discussion. In 2009 the Medical Association called for a broad debate in order to
      achieve equity among all patients. The long lasting Danish debate on priority
      setting has entailed only very little practical consequences on health care. The 
      main problems seem to have been the missing effort to bundle the various local
      initiatives on a national level and the lack of powerful players to put results
      of the discussion into practice. Nevertheless, today the attitude towards
      priority setting is predominantly positive and even politicians talk freely about
      it.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Pornak, S
AU  - Pornak S
AD  - Institut fur Sozialmedizin, Universitatsklinikum Schleswig-Holstein, Campus
      Lubeck, Germany. shirin.pornak@medizin.uni-luebeck.de
FAU - Meyer, T
AU  - Meyer T
FAU - Raspe, H
AU  - Raspe H
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Priorisierung in der Medizin - Verlauf und Ergebnisse der danischen
      Priorisierungsdebatte.
DEP - 20110727
PL  - Germany
TA  - Gesundheitswesen
JT  - Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes
      (Germany))
JID - 9204210
SB  - IM
MH  - Bioethics
MH  - *Cross-Cultural Comparison
MH  - Denmark
MH  - Germany
MH  - Health Care Rationing/ethics/*organization & administration
MH  - Health Priorities/ethics/*organization & administration
MH  - Health Services Accessibility/ethics/organization & administration
MH  - Humans
MH  - National Health Programs/ethics/*organization & administration
MH  - Politics
MH  - Societies, Medical
EDAT- 2011/07/29 06:00
MHDA- 2012/06/01 06:00
CRDT- 2011/07/29 06:00
PHST- 2011/07/29 06:00 [entrez]
PHST- 2011/07/29 06:00 [pubmed]
PHST- 2012/06/01 06:00 [medline]
AID - 10.1055/s-0031-1280841 [doi]
PST - ppublish
SO  - Gesundheitswesen. 2011 Oct;73(10):680-7. doi: 10.1055/s-0031-1280841. Epub 2011
      Jul 27.


PMID- 21795901
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20151119
IS  - 1938-808X (Electronic)
IS  - 1040-2446 (Linking)
VI  - 86
IP  - 8
DP  - 2011 Aug
TI  - Commentary: to genotype or not to genotype? Addressing the debate through the
      development of a genomics and personalized medicine curriculum.
PG  - 925-7
LID - 10.1097/ACM.0b013e3182223acf [doi]
AB  - As technologic innovation helps broaden and refine our knowledge base of genetic 
      associations, a growing interest in translating these genetic discoveries to
      clinically useful laboratory tests has given rise to the potential of
      personalized medicine. To fully realize this potential, medical schools must
      educate trainees on genetic and genomic testing in clinical settings. An emerging
      debate in academic medical centers is not about the need for this education but, 
      rather, the most effective educational models that should be deployed. At
      Stanford School of Medicine, several proposals to offer personal genotyping in
      the educational curriculum argued that learning genetics and the attendant
      cutting-edge molecular techniques would be more powerful and sustained if
      students were applying their knowledge to their personal genotypes. Given the
      complex ethical, legal, and social issues involved in implementing such a
      program, a schoolwide task force was formed to evaluate the risks and benefits of
      offering personal genotyping to students and residents. In this commentary, the
      authors discuss the salient issues raised by the task force and describe the
      safeguards adopted into the ultimate approval and implementation of the course,
      which included the opportunity for students to analyze their own genomes.
FAU - Salari, Keyan
AU  - Salari K
FAU - Pizzo, Philip A
AU  - Pizzo PA
FAU - Prober, Charles G
AU  - Prober CG
LA  - eng
PT  - Editorial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Acad Med
JT  - Academic medicine : journal of the Association of American Medical Colleges
JID - 8904605
SB  - IM
MH  - Curriculum
MH  - Education, Medical/*organization & administration
MH  - Genomics/*education
MH  - Genotype
MH  - Humans
MH  - *Precision Medicine
MH  - United States
EDAT- 2011/07/29 06:00
MHDA- 2011/10/25 06:00
CRDT- 2011/07/29 06:00
PHST- 2011/07/29 06:00 [entrez]
PHST- 2011/07/29 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
AID - 10.1097/ACM.0b013e3182223acf [doi]
AID - 00001888-201108000-00009 [pii]
PST - ppublish
SO  - Acad Med. 2011 Aug;86(8):925-7. doi: 10.1097/ACM.0b013e3182223acf.


PMID- 21794208
OWN - NLM
STAT- MEDLINE
DCOM- 20120214
LR  - 20211020
IS  - 1944-7930 (Electronic)
IS  - 1539-6509 (Linking)
VI  - 12
IP  - 62
DP  - 2011 Jul
TI  - Exome sequencing and unrelated findings in the context of complex disease
      research: ethical and clinical implications.
PG  - 41-55
AB  - Exome sequencing has identified the causes of several Mendelian diseases,
      although it has rarely been used in a clinical setting to diagnose the genetic
      cause of an idiopathic disorder in a single patient. We performed exome
      sequencing on a pedigree with several members affected with attention
      deficit/hyperactivity disorder (ADHD), in an effort to identify candidate
      variants predisposing to this complex disease. While we did identify some rare
      variants that might predispose to ADHD, we have not yet proven the causality for 
      any of them. However, over the course of the study, one subject was discovered to
      have idiopathic hemolytic anemia (IHA), which was suspected to be genetic in
      origin. Analysis of this subject's exome readily identified two rare
      non-synonymous mutations in PKLR gene as the most likely cause of the IHA,
      although these two mutations had not been documented before in a single
      individual. We further confirmed the deficiency by functional biochemical
      testing, consistent with a diagnosis of red blood cell pyruvate kinase
      deficiency. Our study implies that exome and genome sequencing will certainly
      reveal additional rare variation causative for even well-studied classical
      Mendelian diseases, while also revealing variants that might play a role in
      complex diseases. Furthermore, our study has clinical and ethical implications
      for exome and genome sequencing in a research setting; how to handle unrelated
      findings of clinical significance, in the context of originally planned complex
      disease research, remains a largely uncharted area for clinicians and
      researchers.
FAU - Lyon, Gholson J
AU  - Lyon GJ
AD  - Department of Psychiatry, University of Utah, Salt Lake City, USA.
      lyong1@email.chop.edu
FAU - Jiang, Tao
AU  - Jiang T
FAU - Van Wijk, Richard
AU  - Van Wijk R
FAU - Wang, Wei
AU  - Wang W
FAU - Bodily, Paul Mark
AU  - Bodily PM
FAU - Xing, Jinchuan
AU  - Xing J
FAU - Tian, Lifeng
AU  - Tian L
FAU - Robison, Reid J
AU  - Robison RJ
FAU - Clement, Mark
AU  - Clement M
FAU - Lin, Yang
AU  - Lin Y
FAU - Zhang, Peng
AU  - Zhang P
FAU - Liu, Ying
AU  - Liu Y
FAU - Moore, Barry
AU  - Moore B
FAU - Glessner, Joseph T
AU  - Glessner JT
FAU - Elia, Josephine
AU  - Elia J
FAU - Reimherr, Fred
AU  - Reimherr F
FAU - van Solinge, Wouter W
AU  - van Solinge WW
FAU - Yandell, Mark
AU  - Yandell M
FAU - Hakonarson, Hakon
AU  - Hakonarson H
FAU - Wang, Jun
AU  - Wang J
FAU - Johnson, William Evan
AU  - Johnson WE
FAU - Wei, Zhi
AU  - Wei Z
FAU - Wang, Kai
AU  - Wang K
LA  - eng
GR  - RC2 HG005619/HG/NHGRI NIH HHS/United States
GR  - 1RC2HG005619/HG/NHGRI NIH HHS/United States
GR  - UL1 RR025774/RR/NCRR NIH HHS/United States
GR  - UL 1 RR025774/RR/NCRR NIH HHS/United States
GR  - R01 HG005692/HG/NHGRI NIH HHS/United States
GR  - R44 HG006579/HG/NHGRI NIH HHS/United States
GR  - K99 HG005846/HG/NHGRI NIH HHS/United States
GR  - R01 HG005692-02/HG/NHGRI NIH HHS/United States
GR  - K99HG005846/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Discov Med
JT  - Discovery medicine
JID - 101250006
RN  - EC 2.7.1.40 (Pyruvate Kinase)
SB  - IM
MH  - Amino Acid Sequence
MH  - Anemia, Hemolytic, Autoimmune/complications/enzymology/genetics
MH  - Attention Deficit Disorder with Hyperactivity/complications/*genetics
MH  - DNA Copy Number Variations/genetics
MH  - *Ethics, Research
MH  - Exons/*genetics
MH  - Female
MH  - Genome, Human/genetics
MH  - Humans
MH  - Male
MH  - Molecular Sequence Data
MH  - Pedigree
MH  - Pyruvate Kinase/chemistry/genetics
MH  - Reproducibility of Results
MH  - Sequence Analysis, DNA/*methods
MH  - Software
PMC - PMC3544941
MID - NIHMS350640
EDAT- 2011/07/29 06:00
MHDA- 2012/02/15 06:00
CRDT- 2011/07/29 06:00
PHST- 2011/07/29 06:00 [entrez]
PHST- 2011/07/29 06:00 [pubmed]
PHST- 2012/02/15 06:00 [medline]
PST - ppublish
SO  - Discov Med. 2011 Jul;12(62):41-55.


PMID- 21794080
OWN - NLM
STAT- MEDLINE
DCOM- 20120619
LR  - 20220318
IS  - 1600-9657 (Electronic)
IS  - 1600-4469 (Linking)
VI  - 28
IP  - 1
DP  - 2012 Feb
TI  - Traumatic dental injuries and their association with malocclusion in the primary 
      dentition of Irish children.
PG  - 81-6
LID - 10.1111/j.1600-9657.2011.01032.x [doi]
AB  - AIMS: This study sought to establish the prevalence of traumatic dental injuries 
      in the primary dentition of Irish children and to investigate the relationship
      between dental trauma and non-nutritive sucking habits. MATERIALS AND METHODS:
      Following ethical approval, a variety of schools and creches in an urban setting 
      were identified and parents of over 1000 children were contacted. Consent was
      obtained, and parental questionnaires were completed prior to a clinical
      examination of the children by one operator in a non-dental setting. Signs of
      previous dental trauma were noted, and overbite and overjet were measured.
      RESULTS: Eight hundred and thirty-nine children were examined. The prevalence of 
      dental trauma was 25.6%, with boys more frequently affected. The most commonly
      observed dental injury was fracture of enamel (39.4%), followed by crown
      discolouration (20.2%). Only 38.8% of the children with a reported history of
      trauma sought dental care. Non-nutritive sucking habits were reported in 63.5% of
      the sample, and these habits, if prolonged, were significantly associated with
      anterior open bites and increased overjet (P<0.001). Using regression analysis,
      it was established that the risk of dental injury is 2.99 times greater if the
      child has an overjet >6mm and 2.02 times greater if the child has an anterior
      open bite. CONCLUSIONS: Non-nutritive sucking habits are associated with the
      establishment of anterior open bite and increased overjet in the primary
      dentition. These malocclusions are, in turn, significantly associated with an
      increased prevalence of dental trauma in the primary dentition.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Norton, Eimear
AU  - Norton E
AD  - Division of Public and Child Dental Health, Dublin Dental University Hospital,
      Trinity College, Dublin 2, Ireland. eimear.norton@dental.tcd.ie
FAU - O'Connell, Anne C
AU  - O'Connell AC
LA  - eng
PT  - Journal Article
DEP - 20110727
PL  - Denmark
TA  - Dent Traumatol
JT  - Dental traumatology : official publication of International Association for
      Dental Traumatology
JID - 101091305
MH  - Age Factors
MH  - Child
MH  - Child, Preschool
MH  - Dental Enamel/injuries
MH  - Dentin/injuries
MH  - Female
MH  - Fingersucking
MH  - Humans
MH  - Infant
MH  - Ireland/epidemiology
MH  - Male
MH  - Malocclusion/*epidemiology
MH  - Open Bite/epidemiology
MH  - Overbite/epidemiology
MH  - Pacifiers/statistics & numerical data
MH  - Prevalence
MH  - Sex Factors
MH  - Sucking Behavior
MH  - Tooth Crown/injuries
MH  - Tooth Discoloration/epidemiology
MH  - Tooth, Deciduous/*injuries
MH  - Urban Health/statistics & numerical data
EDAT- 2011/07/29 06:00
MHDA- 2012/06/20 06:00
CRDT- 2011/07/29 06:00
PHST- 2011/07/29 06:00 [entrez]
PHST- 2011/07/29 06:00 [pubmed]
PHST- 2012/06/20 06:00 [medline]
AID - 10.1111/j.1600-9657.2011.01032.x [doi]
PST - ppublish
SO  - Dent Traumatol. 2012 Feb;28(1):81-6. doi: 10.1111/j.1600-9657.2011.01032.x. Epub 
      2011 Jul 27.


PMID- 21794072
OWN - NLM
STAT- MEDLINE
DCOM- 20120221
LR  - 20211020
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 11
IP  - 3
DP  - 2011 Dec
TI  - The reporting of IRB review in journal articles presenting HIV research conducted
      in the developing world.
PG  - 161-9
LID - 10.1111/j.1471-8847.2011.00306.x [doi]
AB  - OBJECTIVES: We investigated how often journal articles reporting on human HIV
      research in four developing world countries mention any institutional review
      boards (IRBs) or research ethics committees (RECs), and what factors are
      involved. METHODS: We examined all such articles published in 2007 from India,
      Nigeria, Thailand and Uganda, and coded these for several ethical and other
      characteristics. RESULTS: Of 221 articles meeting inclusion criteria, 32.1% did
      not mention IRB approval. Mention of IRB approval was associated with: biomedical
      (versus psychosocial) research (P=0.001), more sponsor-country authors (P=0.003),
      sponsor-country corresponding author (P=0.047), mention of funding (P<0.001),
      particular host-country involved (P=0.002), journals having sponsor-country
      editors (P<0.001), and journal stated compliance with International Committee of 
      Medical Journal Editors (ICMJE) guidelines (P=0.003). Logistic regression
      identified 3 significant factors: mention of funding, journal having
      sponsor-country editors and research being biomedical. CONCLUSIONS: One-third of 
      articles still do not mention IRB approval. Mention varied by country, and was
      associated with biomedical research, and more sponsor country involvement.
      Recently, some journals have required mention of IRB approval, but allow authors 
      to do so in cover letters to editors, not in the article itself. Instead, these
      data suggest, journals should require that articles document adherence to ethical
      standards.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Klitzman, Robert L
AU  - Klitzman RL
AD  - Columbia University College of Physicians and Surgeons-Psychiatry, 1051 Riverside
      Drive, New York, NY 10032, USA. rlk2@columbia.edu
FAU - Kleinert, Kelly
AU  - Kleinert K
FAU - Rifai-Bashjawish, Hoda
AU  - Rifai-Bashjawish H
FAU - Leu, Cheng Shiung
AU  - Leu CS
LA  - eng
GR  - 5R01HG04214/HG/NHGRI NIH HHS/United States
GR  - P30 MH043520/MH/NIMH NIH HHS/United States
GR  - T35 HL007616/HL/NHLBI NIH HHS/United States
GR  - 5 G13 LM009996-02/LM/NLM NIH HHS/United States
GR  - R01 HG004214/HG/NHGRI NIH HHS/United States
GR  - G13 LM009996/LM/NLM NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110725
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
SB  - IM
MH  - Authorship
MH  - Biomedical Research/ethics/*standards
MH  - Clinical Trials as Topic/ethics/*standards
MH  - Conflict of Interest
MH  - *Developing Countries
MH  - *Ethics Committees, Research
MH  - *HIV Infections
MH  - Humans
MH  - India
MH  - Informed Consent/statistics & numerical data
MH  - Logistic Models
MH  - Nigeria
MH  - Periodicals as Topic
MH  - Research Design
MH  - Research Report/*standards
MH  - Thailand
MH  - Uganda
MH  - Vulnerable Populations/statistics & numerical data
PMC - PMC3459234
MID - NIHMS291403
EDAT- 2011/07/29 06:00
MHDA- 2012/02/22 06:00
CRDT- 2011/07/29 06:00
PHST- 2011/07/29 06:00 [entrez]
PHST- 2011/07/29 06:00 [pubmed]
PHST- 2012/02/22 06:00 [medline]
AID - 10.1111/j.1471-8847.2011.00306.x [doi]
PST - ppublish
SO  - Dev World Bioeth. 2011 Dec;11(3):161-9. doi: 10.1111/j.1471-8847.2011.00306.x.
      Epub 2011 Jul 25.


PMID- 21794071
OWN - NLM
STAT- MEDLINE
DCOM- 20120221
LR  - 20111122
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 11
IP  - 3
DP  - 2011 Dec
TI  - Sex selection abortion in Kazakhstan: understanding a cultural justification.
PG  - 154-60
LID - 10.1111/j.1471-8847.2011.00303.x [doi]
AB  - The topic of abortion has been extensively researched, and the research has
      produced a large number of arguments and discussions. Missing in the literature, 
      however, are discussions of practices in some areas of the Developing or Third
      World. In this paper, we examine the morality of sex selection abortions in
      Kazakhstan's Kazakh culture, and argue that such abortions can be ethically
      justified based, in part, on the unique perspectives of Kazakh culture.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Cooley, Dennis
AU  - Cooley D
AD  - Northern Plains Ethics Institute, Department of History, Philosophy and Religious
      Studies, North Dakota State University, Fargo, ND 58108, USA.
      dennis.cooley@ndsu.edu
FAU - Chesnokova, Irina
AU  - Chesnokova I
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20110725
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
SB  - IM
MH  - Abortion, Induced/*ethics
MH  - *Cultural Characteristics
MH  - Female
MH  - Humans
MH  - Kazakhstan
MH  - Male
MH  - Morals
MH  - Pregnancy
MH  - *Pregnancy, Unwanted
MH  - *Sex Preselection
EDAT- 2011/07/29 06:00
MHDA- 2012/02/22 06:00
CRDT- 2011/07/29 06:00
PHST- 2011/07/29 06:00 [entrez]
PHST- 2011/07/29 06:00 [pubmed]
PHST- 2012/02/22 06:00 [medline]
AID - 10.1111/j.1471-8847.2011.00303.x [doi]
PST - ppublish
SO  - Dev World Bioeth. 2011 Dec;11(3):154-60. doi: 10.1111/j.1471-8847.2011.00303.x.
      Epub 2011 Jul 25.


PMID- 21793115
OWN - NLM
STAT- MEDLINE
DCOM- 20110929
LR  - 20110727
IS  - 1074-4797 (Print)
IS  - 1074-4797 (Linking)
VI  - 31
IP  - 1
DP  - 2011
TI  - Ethics, risk, and patient-centered care: how collaboration between clinical
      ethicists and risk management leads to respectful patient care.
PG  - 32-7
LID - 10.1002/jhrm.20077 [doi]
AB  - Patient-centered care is driven in part by the ethical principle of autonomy and 
      considers patients' cultural traditions, personal preferences, values, family
      situations, and lifestyles. Patient decision-making capacity, surrogate decision 
      making with or in the absence of a patient's advance directive, and the right to 
      refuse treatment are three patient-care issues that are central to the work done 
      by both the risk manager and the clinical ethicist that have strong relevance to 
      patient-centered care. This article discusses these three issues briefly and
      offers two challenging case studies involving patient-centered care that
      illustrate how a clinical ethics consultation may help to avert the escalation
      that can lead to a tort claim.
CI  - (c) 2011 American Society for Healthcare Risk Management of the American Hospital
      Association.
FAU - Sine, David M
AU  - Sine DM
AD  - National Center for Patient Safety, the Veterans Health Administration, USA.
FAU - Sharpe, Virginia A
AU  - Sharpe VA
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Healthc Risk Manag
JT  - Journal of healthcare risk management : the journal of the American Society for
      Healthcare Risk Management
JID - 9305245
MH  - Adult
MH  - Advance Directives
MH  - Aged
MH  - *Cooperative Behavior
MH  - *Ethics, Clinical
MH  - Female
MH  - Humans
MH  - Patient Satisfaction
MH  - *Patient-Centered Care
MH  - *Risk Management
MH  - Treatment Refusal
MH  - United States
EDAT- 2011/07/28 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/07/28 06:00
PHST- 2011/07/28 06:00 [entrez]
PHST- 2011/07/28 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - 10.1002/jhrm.20077 [doi]
PST - ppublish
SO  - J Healthc Risk Manag. 2011;31(1):32-7. doi: 10.1002/jhrm.20077.


PMID- 21792972
OWN - NLM
STAT- MEDLINE
DCOM- 20110923
LR  - 20211020
IS  - 1531-4995 (Electronic)
IS  - 0023-852X (Linking)
VI  - 121
IP  - 8
DP  - 2011 Aug
TI  - The right not to hear: the ethics of parental refusal of hearing rehabilitation.
PG  - 1800-4
LID - 10.1002/lary.21886 [doi]
AB  - OBJECTIVE: To explore the ethics of parental refusal of auditory-oral hearing
      rehabilitation. STUDY DESIGN: Case study with medical ethical discussion and
      review. METHODS: Two young brothers present with severe-to-profound congenital
      sensorineural hearing loss. The parents, both of whom have normal hearing and
      work as sign language interpreters, have decided to raise their children with
      American Sign Language as their only form of communication. They have chosen not 
      to pursue cochlear implantation nor support the use of hearing aids. DISCUSSION: 
      This case raises significant questions concerning whether hearing rehabilitation 
      should be mandated, and if there are circumstances in which parental preferences 
      should be questioned or overridden with regard to this issue. In addition, legal 
      concerns may be raised regarding the possible need to file a report with Child
      Protective Services. Although similar cases involving the Deaf community have
      historically favored parental rights to forego hearing rehabilitation with either
      cochlear implantation or hearing aids, we explore whether conclusions should be
      different because the parents in this case are not hearing impaired. CONCLUSIONS:
      The ethics of parental rights to refuse hearing rehabilitation are complex and
      strikingly context-dependent. A comprehensive appreciation of the medical,
      practical, and legal issues is crucial prior to intervening in such challenging
      situations.
CI  - Copyright (c) 2011 The American Laryngological, Rhinological, and Otological
      Society, Inc.
FAU - Byrd, Serena
AU  - Byrd S
AD  - Department of Otolaryngology, University of Michigan Medical School, Ann Arbor,
      Michigan, USA.
FAU - Shuman, Andrew G
AU  - Shuman AG
FAU - Kileny, Sharon
AU  - Kileny S
FAU - Kileny, Paul R
AU  - Kileny PR
LA  - eng
GR  - T32 DC005356/DC/NIDCD NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
SB  - IM
MH  - Child, Preschool
MH  - Cochlear Implantation/*ethics
MH  - Hearing Loss, Sensorineural/congenital/*surgery
MH  - Humans
MH  - Infant
MH  - Male
MH  - Parental Consent/ethics
MH  - Parents/*psychology
MH  - Persons With Hearing Impairments/psychology
MH  - Treatment Refusal/*ethics
PMC - PMC4493436
MID - NIHMS700572
EDAT- 2011/07/28 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/07/28 06:00
PHST- 2011/07/28 06:00 [entrez]
PHST- 2011/07/28 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 10.1002/lary.21886 [doi]
PST - ppublish
SO  - Laryngoscope. 2011 Aug;121(8):1800-4. doi: 10.1002/lary.21886.


PMID- 21792683
OWN - NLM
STAT- MEDLINE
DCOM- 20120206
LR  - 20211020
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 23
IP  - 3
DP  - 2011 Sep
TI  - Client participation in moral case deliberation: a precarious relational balance.
PG  - 207-24
LID - 10.1007/s10730-011-9157-6 [doi]
AB  - Moral case deliberation (MCD) is a form of clinical ethics support in which the
      ethicist as facilitator aims at supporting professionals with a structured moral 
      inquiry into their moral issues from practice. Cases often affect clients,
      however, their inclusion in MCD is not common. Client participation often raises 
      questions concerning conditions for equal collaboration and good dialogue.
      Despite these questions, there is little empirical research regarding client
      participation in clinical ethics support in general and in MCD in particular.
      This article aims at describing the experiences and processes of two MCD groups
      with client participation in a mental healthcare institution. A responsive
      evaluation was conducted examining stakeholders' issues concerning client
      participation. Findings demonstrate that participation initially creates
      uneasiness. As routine builds up and client participants meet certain criteria,
      both clients and professionals start thinking beyond 'us-them' distinctions, and 
      become more equal partners in dialogue. Still, sentiments of distrust and
      feelings of not being safe may reoccur. Client participation in MCD thus requires
      continuous reflection and alertness on relational dynamics and the quality of and
      conditions for dialogue. Participation puts the essentials of MCD (i.e.,
      dialogue) to the test. Yet, the methodology and features of MCD offer an
      appropriate platform to introduce client participation in healthcare
      institutions.
FAU - Weidema, F C
AU  - Weidema FC
AD  - Department of Medical Humanities, Free University Medical Centre, Amsterdam, The 
      Netherlands. f.weidema@ggnet.nl
FAU - Abma, T A
AU  - Abma TA
FAU - Widdershoven, G A M
AU  - Widdershoven GA
FAU - Molewijk, A C
AU  - Molewijk AC
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - Coercion
MH  - Communication
MH  - Ethics Committees, Clinical/*organization & administration
MH  - Hospitals, Psychiatric/*ethics
MH  - Humans
MH  - Morals
MH  - Netherlands
MH  - *Patient Participation
MH  - *Process Assessment, Health Care
MH  - Restraint, Physical/ethics
MH  - Trust
PMC - PMC3178761
EDAT- 2011/07/28 06:00
MHDA- 2012/02/07 06:00
CRDT- 2011/07/28 06:00
PHST- 2011/07/28 06:00 [entrez]
PHST- 2011/07/28 06:00 [pubmed]
PHST- 2012/02/07 06:00 [medline]
AID - 10.1007/s10730-011-9157-6 [doi]
PST - ppublish
SO  - HEC Forum. 2011 Sep;23(3):207-24. doi: 10.1007/s10730-011-9157-6.


PMID- 21791934
OWN - NLM
STAT- MEDLINE
DCOM- 20120719
LR  - 20111222
IS  - 1661-7819 (Electronic)
IS  - 1661-7800 (Linking)
VI  - 101
IP  - 1
DP  - 2012
TI  - Advanced clinical medicine requires advanced clinical ethics.
PG  - 8-12
LID - 10.1159/000325162 [doi]
AB  - Many advances have occurred in clinical medicine in the last decades. Solid organ
      transplants, corrective surgery for congenital malformations, improved cytostatic
      regimes for children with cancer, and respiratory care for premature infants are 
      but a few examples of the changing face of medical practice. Such changes have
      added years to life. But along the way many patients have paid a price, both in
      terms of loss of life and of added suffering. Even today, some survivors are
      faced with a life of impairment and suffering. Follow-up studies of extremely
      low-birth-weight infants show that the smallest infants have a high rate of
      severe sequelae. Some argue that such suffering should be sufficient reason to
      make us desist from further attempts to advance the frontiers of therapy. This
      paper seeks to reflect on the character of advanced medicine and on how we relate
      to patients and their kin in our quest for further improvements in therapy. The
      price for continued advances will inevitably be paid by some patients who will
      not profit from them. Therefore, patients who are asked to participate in such a 
      quest must receive honest and transparent information, including a discussion
      about where and how they would draw the limits. Clinical competency is a core
      concept in advanced medicine, but a caring comportment also demands that our
      relationship to the patient be characterized by honesty, integrity, and decency. 
      In dialogue with parents, finding the right balance between parental exercise of 
      autonomy and safe-guarding the best interest of the child remains a challenge.
CI  - Copyright (c) 2011 S. Karger AG, Basel.
FAU - Hansen, Thor Willy Ruud
AU  - Hansen TW
AD  - Department of Neonatology, Women's and Children's Division and Clinical Ethics
      Committee, Oslo University Hospital HC-Rikshospitalet, Oslo, Norway.
      t.w.r.hansen@medisin.uio.no
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110726
PL  - Switzerland
TA  - Neonatology
JT  - Neonatology
JID - 101286577
SB  - IM
MH  - *Ethics, Medical
MH  - Humans
MH  - Infant Care/*ethics/methods
MH  - *Infant, Extremely Low Birth Weight
MH  - Infant, Newborn
MH  - Infant, Newborn, Diseases/*therapy
MH  - *Infant, Premature
MH  - Intensive Care, Neonatal/ethics/methods
MH  - Neonatology/*ethics/methods
MH  - Patient Rights/ethics
MH  - Patient Selection
MH  - Physician-Patient Relations/ethics
EDAT- 2011/07/28 06:00
MHDA- 2012/07/20 06:00
CRDT- 2011/07/28 06:00
PHST- 2010/12/15 00:00 [received]
PHST- 2011/02/04 00:00 [accepted]
PHST- 2011/07/28 06:00 [entrez]
PHST- 2011/07/28 06:00 [pubmed]
PHST- 2012/07/20 06:00 [medline]
AID - 000325162 [pii]
AID - 10.1159/000325162 [doi]
PST - ppublish
SO  - Neonatology. 2012;101(1):8-12. doi: 10.1159/000325162. Epub 2011 Jul 26.


PMID- 21791267
OWN - NLM
STAT- MEDLINE
DCOM- 20111005
LR  - 20220409
IS  - 1558-1357 (Electronic)
IS  - 0029-6465 (Linking)
VI  - 46
IP  - 3
DP  - 2011 Sep
TI  - Promoting health literacy: a nursing imperative.
PG  - 321-33, vi-vii
LID - 10.1016/j.cnur.2011.05.007 [doi]
AB  - It is imperative that nursing responds to the call of creating a health literate 
      society by taking an active role in health literacy research, education, and
      promotion. Nurses have a professional and ethical obligation to communicate in a 
      clear, purposeful way that addresses the unique information needs of each
      patient. Evidence-based strategies that promote health literacy must be
      incorporated in every patient's plan of care and become part of the routine
      practice of nursing. The goal of all patient interactions should be to empower
      the patient to obtain, understand, and act on information that is needed for
      optimal health. This article explores the concept of health literacy and its
      relationship to patient education and communication. Practical strategies that
      the nurse can use to assess, communicate with, and evaluate comprehension in
      patients with low literacy skills are provided.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Speros, Carolyn I
AU  - Speros CI
AD  - University of Memphis, Loewenberg School of Nursing, Newport Hall, Memphis, TN
      38152, USA. csperos@memphis.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Nurs Clin North Am
JT  - The Nursing clinics of North America
JID - 0042033
SB  - IM
MH  - Adult
MH  - *Health Literacy
MH  - *Health Promotion
MH  - Humans
MH  - Nurse-Patient Relations
MH  - Nursing Assessment/*methods
MH  - *Patient Education as Topic
MH  - Patient-Centered Care
MH  - Social Support
MH  - Teaching/*methods
MH  - United States
EDAT- 2011/07/28 06:00
MHDA- 2011/10/06 06:00
CRDT- 2011/07/28 06:00
PHST- 2011/07/28 06:00 [entrez]
PHST- 2011/07/28 06:00 [pubmed]
PHST- 2011/10/06 06:00 [medline]
AID - S0029-6465(11)00032-6 [pii]
AID - 10.1016/j.cnur.2011.05.007 [doi]
PST - ppublish
SO  - Nurs Clin North Am. 2011 Sep;46(3):321-33, vi-vii. doi:
      10.1016/j.cnur.2011.05.007.


PMID- 21791263
OWN - NLM
STAT- MEDLINE
DCOM- 20111005
LR  - 20110727
IS  - 1558-1357 (Electronic)
IS  - 0029-6465 (Linking)
VI  - 46
IP  - 3
DP  - 2011 Sep
TI  - Ethics of patient education and how do we make it everyone's ethics.
PG  - 283-9, v
LID - 10.1016/j.cnur.2011.05.001 [doi]
AB  - Patient education has long been central to nursing's philosophy of practice, and,
      because of this commitment, nurses in all practice settings have been deeply
      distressed with the careless and generally incomplete manner in which it is
      practiced in the health care system. This article examines the ethical
      underpinning of this distress and of this neglect in patient education and what
      actions nurses can take to correct this situation.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Redman, Barbara K
AU  - Redman BK
AD  - Wayne State University, College of Nursing, 5557 Cass Avenue, Detroit, MI 48202, 
      USA. ae9080@wayne.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Nurs Clin North Am
JT  - The Nursing clinics of North America
JID - 0042033
SB  - IM
MH  - Chronic Disease/nursing/*therapy
MH  - Drug Monitoring
MH  - *Health Services Needs and Demand
MH  - Humans
MH  - Models, Organizational
MH  - Nurse's Role
MH  - Organizational Culture
MH  - Patient Education as Topic/*ethics/organization & administration
MH  - Physician-Nurse Relations
MH  - *Safety Management/organization & administration
MH  - *Self Care
EDAT- 2011/07/28 06:00
MHDA- 2011/10/06 06:00
CRDT- 2011/07/28 06:00
PHST- 2011/07/28 06:00 [entrez]
PHST- 2011/07/28 06:00 [pubmed]
PHST- 2011/10/06 06:00 [medline]
AID - S0029-6465(11)00026-0 [pii]
AID - 10.1016/j.cnur.2011.05.001 [doi]
PST - ppublish
SO  - Nurs Clin North Am. 2011 Sep;46(3):283-9, v. doi: 10.1016/j.cnur.2011.05.001.


PMID- 21791064
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20211020
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 12
DP  - 2011 Jul 26
TI  - Who is the research subject in cluster randomized trials in health research?
PG  - 183
LID - 10.1186/1745-6215-12-183 [doi]
AB  - This article is part of a series of papers examining ethical issues in cluster
      randomized trials (CRTs) in health research. In the introductory paper in this
      series, we set out six areas of inquiry that must be addressed if the CRT is to
      be set on a firm ethical foundation. This paper addresses the first of the
      questions posed, namely, who is the research subject in a CRT in health research?
      The identification of human research subjects is logically prior to the
      application of protections as set out in research ethics and regulation. Aspects 
      of CRT design, including the fact that in a single study the units of
      randomization, experimentation, and observation may differ, complicate the
      identification of human research subjects. But the proper identification of human
      research subjects is important if they are to be protected from harm and
      exploitation, and if research ethics committees are to review CRTs efficiently.We
      examine the research ethics literature and international regulations to identify 
      the core features of human research subjects, and then unify these features under
      a single, comprehensive definition of human research subject. We define a human
      research subject as any person whose interests may be compromised as a result of 
      interventions in a research study. Individuals are only human research subjects
      in CRTs if: (1) they are directly intervened upon by investigators; (2) they
      interact with investigators; (3) they are deliberately intervened upon via a
      manipulation of their environment that may compromise their interests; or (4)
      their identifiable private information is used to generate data. Individuals who 
      are indirectly affected by CRT study interventions, including patients of
      healthcare providers participating in knowledge translation CRTs, are not human
      research subjects unless at least one of these conditions is met.
FAU - McRae, Andrew D
AU  - McRae AD
AD  - Department of Epidemiology and Biostatistics, University of Western Ontario,
      London, Canada. andrew.mcrae@albertahealthservices.ca
FAU - Weijer, Charles
AU  - Weijer C
FAU - Binik, Ariella
AU  - Binik A
FAU - White, Angela
AU  - White A
FAU - Grimshaw, Jeremy M
AU  - Grimshaw JM
FAU - Boruch, Robert
AU  - Boruch R
FAU - Brehaut, Jamie C
AU  - Brehaut JC
FAU - Donner, Allan
AU  - Donner A
FAU - Eccles, Martin P
AU  - Eccles MP
FAU - Saginur, Raphael
AU  - Saginur R
FAU - Zwarenstein, Merrick
AU  - Zwarenstein M
FAU - Taljaard, Monica
AU  - Taljaard M
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110726
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
SB  - IM
MH  - *Cluster Analysis
MH  - Confidentiality
MH  - Health Services Research/ethics/legislation & jurisprudence/*methods
MH  - Humans
MH  - Patient Rights
MH  - *Patient Selection/ethics
MH  - Professional-Patient Relations
MH  - Randomized Controlled Trials as Topic/ethics/legislation & jurisprudence/*methods
MH  - Research Subjects/*classification/legislation & jurisprudence
MH  - Risk Assessment
MH  - *Terminology as Topic
MH  - Treatment Outcome
PMC - PMC3162904
EDAT- 2011/07/28 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/07/28 06:00
PHST- 2010/09/30 00:00 [received]
PHST- 2011/07/26 00:00 [accepted]
PHST- 2011/07/28 06:00 [entrez]
PHST- 2011/07/28 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - 1745-6215-12-183 [pii]
AID - 10.1186/1745-6215-12-183 [doi]
PST - epublish
SO  - Trials. 2011 Jul 26;12:183. doi: 10.1186/1745-6215-12-183.


PMID- 21790963
OWN - NLM
STAT- MEDLINE
DCOM- 20120221
LR  - 20111122
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 11
IP  - 3
DP  - 2011 Dec
TI  - HIV testing of pregnant women: an ethical analysis.
PG  - 109-19
LID - 10.1111/j.1471-8847.2011.00304.x [doi]
AB  - Recent global advances in available technology to prevent mother-to-child HIV
      transmission necessitate a rethinking of contemporary and previous ethical
      debates on HIV testing as a means to preventing vertical transmission. In this
      paper, we will provide an ethical analysis of HIV-testing strategies of pregnant 
      women. First, we argue that provider-initiated opt-out HIV testing seems to be
      the most effective HIV test strategy. The flip-side of an opt-out strategy is
      that it may end up as involuntary testing in a clinical setting. We analyse this 
      ethical puzzle from a novel perspective, taking into account the moral importance
      of certain hypothetical preferences of the child, as well as the moral importance
      of certain actual preferences of the mother. Finally, we balance the conflicting 
      concerns and try to arrive at an ethically sound solution to this dilemma. Our
      aim is to introduce a novel perspective from which to analyse testing strategies,
      and to explore the implications and possible benefits of our proposal. The
      conclusion from our analysis is that policies that recommend provider-initiated
      opt-out HIV testing of pregnant mothers, with a risk of becoming involuntary
      testing in a clinical setting, are acceptable. The rationale behind this is that 
      the increased availability of very effective and inexpensive life-saving drugs
      makes the ethical problems raised by the possible intrusiveness of HIV testing
      less important than the child's hypothetical preferences to be born healthy.
      Health care providers, therefore, have a duty to offer both opt-out HIV testing
      and available PMTCT (preventing mother-to-child transmission) interventions.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Johansson, Kjell Arne
AU  - Johansson KA
AD  - University of Bergen, and Department of Obstetrics and Gynaecology at Haukeland
      University Hospital, University of Bergen, Norway. kjell.johansson@isf.uib.no
FAU - Pedersen, Kirsten Bjerkreim
AU  - Pedersen KB
FAU - Andersson, Anna-Karin
AU  - Andersson AK
LA  - eng
PT  - Journal Article
DEP - 20110725
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
SB  - IM
MH  - AIDS Serodiagnosis/*ethics
MH  - Coercion
MH  - Ethical Analysis
MH  - Female
MH  - HIV Infections/*diagnosis/*prevention & control/transmission
MH  - Humans
MH  - Infectious Disease Transmission, Vertical/*prevention & control
MH  - Mass Screening/*ethics
MH  - Mother-Child Relations
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/*diagnosis/prevention & control
MH  - Pregnant Women/psychology
MH  - Prenatal Care/*ethics
MH  - Volition
EDAT- 2011/07/28 06:00
MHDA- 2012/02/22 06:00
CRDT- 2011/07/28 06:00
PHST- 2011/07/28 06:00 [entrez]
PHST- 2011/07/28 06:00 [pubmed]
PHST- 2012/02/22 06:00 [medline]
AID - 10.1111/j.1471-8847.2011.00304.x [doi]
PST - ppublish
SO  - Dev World Bioeth. 2011 Dec;11(3):109-19. doi: 10.1111/j.1471-8847.2011.00304.x.
      Epub 2011 Jul 25.


PMID- 21790960
OWN - NLM
STAT- MEDLINE
DCOM- 20111006
LR  - 20111229
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 11
IP  - 2
DP  - 2011 Aug
TI  - International service learning programs: ethical issues and recommendations.
PG  - 93-8
LID - 10.1111/j.1471-8847.2011.00299.x [doi]
AB  - Inequities in global health are increasingly of interest to health care providers
      in developed countries. In response, many academic healthcare programs have begun
      to offer international service learning programs. Participants in these programs 
      are motivated by ethical principles, but this type of work presents significant
      ethical challenges, and no formalized ethical guidelines for these activities
      exist. In this paper the ethical issues presented by international service
      learning programs are described and recommendations are made for how academic
      healthcare programs can carry out international service learning programs in a
      way that minimizes ethical conflicts and maximizes benefits for all stakeholders.
      Issues related to project sustainability and community involvement are
      emphasized.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Reisch, Rebecca A
AU  - Reisch RA
AD  - Pacific University School of Physical Therapy, Hillsboro, Oregon, USA.
      reischra@pacificu.edu
LA  - eng
PT  - Journal Article
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
SB  - IM
CIN - Dev World Bioeth. 2011 Dec;11(3):170. PMID: 22103639
MH  - Bioethical Issues
MH  - Bioethics/*education
MH  - *Developing Countries
MH  - Education, Professional/*organization & administration/standards/trends
MH  - Humans
MH  - Interdisciplinary Communication
MH  - *International Cooperation
MH  - Nicaragua
MH  - *Program Development
MH  - Students
EDAT- 2011/07/28 06:00
MHDA- 2011/10/07 06:00
CRDT- 2011/07/28 06:00
PHST- 2011/07/28 06:00 [entrez]
PHST- 2011/07/28 06:00 [pubmed]
PHST- 2011/10/07 06:00 [medline]
AID - 10.1111/j.1471-8847.2011.00299.x [doi]
PST - ppublish
SO  - Dev World Bioeth. 2011 Aug;11(2):93-8. doi: 10.1111/j.1471-8847.2011.00299.x.


PMID- 21790695
OWN - NLM
STAT- MEDLINE
DCOM- 20111209
LR  - 20110727
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 25
IP  - 7
DP  - 2011 Sep
TI  - Responsibility after the apparent end: 'following-up' in clinical ethics
      consultation.
PG  - 413-24
LID - 10.1111/j.1467-8519.2011.01910.x [doi]
AB  - Clinical ethics literature typically presents ethics consultations as having
      clear beginnings and clear ends. Experience in actual clinical ethics practice,
      however, reflects a different characterization, particularly when the moral
      experiences of ethics consultants are included in the discussion. In response,
      this article emphasizes listening and learning about moral experience as core
      activities associated with clinical ethics consultation. This focus reveals that 
      responsibility in actual clinical ethics practice is generated within the moral
      scope of an ethics consultant's activities as she or he encounters the unique and
      specific features that emerge from interactions with a specific patient, or
      family, or practitioner within a given situation and over time. A long-form
      narrative about an ethics consultant's interactions is interwoven with a more
      didactic discussion to highlight the theme of responsibility and to probe
      questions that arise regarding follow-up within the practice of clinical ethics
      consultation.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Finder, Stuart G
AU  - Finder SG
AD  - Center for Healthcare Ethics, Cedars-Sinai Medical Center in Los Angeles,
      California, USA. stuart.finder@cshs.org
FAU - Bliton, Mark J
AU  - Bliton MJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Blood Transfusion/ethics
MH  - Emergencies
MH  - *Ethicists
MH  - *Ethics Consultation
MH  - *Ethics, Clinical
MH  - Humans
MH  - *Interpersonal Relations
MH  - Jehovah's Witnesses
MH  - Male
MH  - Narration
MH  - *Social Responsibility
MH  - United States
EDAT- 2011/07/28 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/07/28 06:00
PHST- 2011/07/28 06:00 [entrez]
PHST- 2011/07/28 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 10.1111/j.1467-8519.2011.01910.x [doi]
PST - ppublish
SO  - Bioethics. 2011 Sep;25(7):413-24. doi: 10.1111/j.1467-8519.2011.01910.x.


PMID- 21790694
OWN - NLM
STAT- MEDLINE
DCOM- 20111209
LR  - 20110727
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 25
IP  - 7
DP  - 2011 Sep
TI  - Evidence - competence - discourse: the theoretical framework of the multi-centre 
      clinical ethics support project METAP.
PG  - 403-12
LID - 10.1111/j.1467-8519.2011.01915.x [doi]
AB  - In this paper we assume that 'theory' is important for Clinical Ethics Support
      Services (CESS). We will argue that the underlying implicit theory should be
      reflected. Moreover, we suggest that the theoretical components on which any
      clinical ethics support (CES) relies should be explicitly articulated in order to
      enhance the quality of CES. A theoretical framework appropriate for CES will be
      necessarily complex and should include ethical (both descriptive and normative), 
      metaethical and organizational components. The various forms of CES that exist in
      North-America and in Europe show their underlying theory more or less explicitly,
      with most of them referring to some kind of theoretical components including
      'how-to' questions (methodology), organizational issues (implementation), problem
      analysis (phenomenology or typology of problems), and related ethical issues such
      as end-of-life decisions (major ethical topics). In order to illustrate and
      explain the theoretical framework that we are suggesting for our own CES project 
      METAP, we will outline this project which has been established in a multi-centre 
      context in several healthcare institutions. We conceptualize three 'pillars' as
      the major components of our theoretical framework: (1) evidence, (2) competence, 
      and (3) discourse. As a whole, the framework is aimed at developing a foundation 
      of our CES project METAP. We conclude that this specific integration of
      theoretical components is a promising model for the fruitful further development 
      of CES.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Reiter-Theil, Stella
AU  - Reiter-Theil S
AD  - Department of Medical and Health Ethics, Medical Faculty/University Hospital
      Basel, Switzerland.
FAU - Mertz, Marcel
AU  - Mertz M
FAU - Schurmann, Jan
AU  - Schurmann J
FAU - Stingelin Giles, Nicola
AU  - Stingelin Giles N
FAU - Meyer-Zehnder, Barbara
AU  - Meyer-Zehnder B
LA  - eng
PT  - Journal Article
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Decision Making/ethics
MH  - *Ethics Consultation
MH  - Europe
MH  - Evidence-Based Practice/*ethics
MH  - Health Care Rationing/*ethics
MH  - Humans
MH  - Models, Theoretical
MH  - North America
MH  - Patient Care Team/*ethics
MH  - Patient Rights/*ethics
EDAT- 2011/07/28 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/07/28 06:00
PHST- 2011/07/28 06:00 [entrez]
PHST- 2011/07/28 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 10.1111/j.1467-8519.2011.01915.x [doi]
PST - ppublish
SO  - Bioethics. 2011 Sep;25(7):403-12. doi: 10.1111/j.1467-8519.2011.01915.x.


PMID- 21790693
OWN - NLM
STAT- MEDLINE
DCOM- 20111209
LR  - 20110727
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 25
IP  - 7
DP  - 2011 Sep
TI  - Mapping out structural features in clinical care calling for ethical sensitivity:
      a theoretical approach to promote ethical competence in healthcare personnel and 
      clinical ethical support services (CESS).
PG  - 394-402
LID - 10.1111/j.1467-8519.2011.01909.x [doi]
AB  - Clinical ethical support services (CESS) represent a multifaceted field of aims, 
      consultancy models, and methodologies. Nevertheless, the overall aim of CESS can 
      be summed up as contributing to healthcare of high ethical standards by improving
      ethically competent decision-making in clinical healthcare. In order to support
      clinical care adequately, CESS must pay systematic attention to all real-life
      ethical issues, including those which do not fall within the 'favourite' ethical 
      issues of the day. In this paper we attempt to capture a comprehensive overview
      of categories of ethical tensions in clinical care. We present an analytical
      exposition of ethical structural features in judgement-based clinical care
      predicated on the assumption of the moral equality of human beings and the
      assessment of where healthcare contexts pose a challenge to achieving moral
      equality. The account and the emerging overview is worked out so that it can be
      easily contextualized with regards to national healthcare systems and specific
      branches of healthcare, as well as local healthcare institutions. By considering 
      how the account and the overview can be applied to i) improve the ethical
      competence of healthcare personnel and consultants by broadening their
      sensitivity to ethical tensions, ii) identify neglected areas for ethical
      research, and iii) clarify the ethical responsibility of healthcare institutions'
      leadership, as well as specifying required institutionalized administration, we
      conclude that the proposed account should be considered useful for CESS.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Baeroe, Kristine
AU  - Baeroe K
AD  - University of Oslo Department of Public Health, University of Bergen.
      kristine.baroe@uni.no
FAU - Norheim, Ole Frithjof
AU  - Norheim OF
LA  - eng
PT  - Journal Article
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Ethical Analysis
MH  - Ethics, Clinical/*education
MH  - Ethics, Institutional/*education
MH  - Evidence-Based Practice/ethics
MH  - Health Personnel/education/*ethics
MH  - Health Services/*ethics
MH  - Humans
MH  - Judgment/ethics
MH  - Morals
MH  - *Staff Development
EDAT- 2011/07/28 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/07/28 06:00
PHST- 2011/07/28 06:00 [entrez]
PHST- 2011/07/28 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 10.1111/j.1467-8519.2011.01909.x [doi]
PST - ppublish
SO  - Bioethics. 2011 Sep;25(7):394-402. doi: 10.1111/j.1467-8519.2011.01909.x.


PMID- 21790692
OWN - NLM
STAT- MEDLINE
DCOM- 20111209
LR  - 20110727
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 25
IP  - 7
DP  - 2011 Sep
TI  - The role of emotions in moral case deliberation: theory, practice, and
      methodology.
PG  - 383-93
LID - 10.1111/j.1467-8519.2011.01914.x [doi]
AB  - In clinical moral decision making, emotions often play an important role.
      However, many clinical ethicists are ignorant, suspicious or even critical of the
      role of emotions in making moral decisions and in reflecting on them. This raises
      practical and theoretical questions about the understanding and use of emotions
      in clinical ethics support services. This paper presents an Aristotelian view on 
      emotions and describes its application in the practice of moral case
      deliberation. According to Aristotle, emotions are an original and integral part 
      of (virtue) ethics. Emotions are an inherent part of our moral reasoning and
      being, and therefore they should be an inherent part of any moral deliberation.
      Based on Aristotle's view, we examine five specific aspects of emotions: the
      description of emotions, the attitude towards emotions, the thoughts present in
      emotions, the reliability of emotions, and the reasonable principle that guides
      an emotion. We then discuss three ways of dealing with emotions in the process of
      moral case deliberation. Finally, we present an Aristotelian conversation method,
      and present practical experiences using this method.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Molewijk, Bert
AU  - Molewijk B
AD  - Department of Medical Humanities and the EMGO+ Institute for Health and Care
      Research, VU University Medical Centre, Amsterdam. b.molewijk@vumc.nl
FAU - Kleinlugtenbelt, Dick
AU  - Kleinlugtenbelt D
FAU - Widdershoven, Guy
AU  - Widdershoven G
LA  - eng
PT  - Journal Article
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Decision Making/*ethics
MH  - *Emotions
MH  - Ethical Theory
MH  - *Ethics Consultation
MH  - *Ethics, Clinical
MH  - Humans
MH  - *Morals
MH  - Philosophy
EDAT- 2011/07/28 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/07/28 06:00
PHST- 2011/07/28 06:00 [entrez]
PHST- 2011/07/28 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 10.1111/j.1467-8519.2011.01914.x [doi]
PST - ppublish
SO  - Bioethics. 2011 Sep;25(7):383-93. doi: 10.1111/j.1467-8519.2011.01914.x.


PMID- 21790691
OWN - NLM
STAT- MEDLINE
DCOM- 20111209
LR  - 20110727
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 25
IP  - 7
DP  - 2011 Sep
TI  - Who are we when we are doing what we are doing?: the case for mindful embodiment 
      in ethics case consultation.
PG  - 370-82
LID - 10.1111/j.1467-8519.2011.01913.x [doi]
AB  - This paper explores the theory and practice of embodied epistemology or mindful
      embodiment in ethics case consultation. I argue that not only is this
      epistemology an ethical imperative to safeguard the integrity of this emerging
      profession, but that it has the potential to improve the quality of ethics
      consultation (EC). It also has implications for how ethics consultants are
      trained and how consultation services are organized. My viewpoint is informed by 
      ethnographic research and by my experimental application of mindful embodiment to
      the development of an ethics consultation service. My argument proceeds in four
      phases. First I explore the notion of 'situatedness' in the bioethics literature,
      identifying gaps in the field's theories as they apply to EC. I then describe my 
      theoretical approach to embodiment grounded in critical-interpretive medical
      anthropology and autoethnography. I use embodiment to refer to a moral
      epistemology grounded in the body, comprised of the interplay of physical,
      symbolic, intersubjective and political elements. Third, I describe how mindful
      embodiment can inform the role of the ethics consultant and the development of
      effective training techniques, vocabularies and processes for EC. I also discuss 
      the benefits of this orientation, and the potential harms of ignoring the
      embodied dimensions of EC. My goals are to expose the fallacy of the
      'theory-practice gap', to demonstrate how my own EC practice is deeply informed
      by this theoretical orientation, and to argue for a wider definition of what
      'counts' as relevant theory for ethics consultation.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Frolic, Andrea
AU  - Frolic A
AD  - Hamilton Health Sciences, Mcmaster University Medical Center, ON, USA.
      Frolic@Hhsc.Ca
LA  - eng
PT  - Journal Article
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Anthropology, Cultural
MH  - Emotions
MH  - Ethical Theory
MH  - Ethicists
MH  - *Ethics Consultation
MH  - *Ethics, Clinical
MH  - Humans
MH  - Interpersonal Relations
MH  - Intuition
MH  - *Knowledge
MH  - *Mind-Body Relations, Metaphysical
MH  - Politics
MH  - *Professional Role
EDAT- 2011/07/28 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/07/28 06:00
PHST- 2011/07/28 06:00 [entrez]
PHST- 2011/07/28 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 10.1111/j.1467-8519.2011.01913.x [doi]
PST - ppublish
SO  - Bioethics. 2011 Sep;25(7):370-82. doi: 10.1111/j.1467-8519.2011.01913.x.


PMID- 21790690
OWN - NLM
STAT- MEDLINE
DCOM- 20111209
LR  - 20110727
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 25
IP  - 7
DP  - 2011 Sep
TI  - Monological versus dialogical consciousness: two epistemological views on the use
      of theory in clinical ethical practice.
PG  - 361-9
LID - 10.1111/j.1467-8519.2011.01912.x [doi]
AB  - In this article, we argue that a critical examination of epistemological and
      anthropological presuppositions might lead to a more fruitful use of theory in
      clinical-ethical practice. We differentiate between two views of conceptualizing 
      ethics, referring to Charles Taylors' two epistemological models: 'monological'
      versus 'dialogical consciousness'. We show that the conception of ethics in the
      model of 'dialogical consciousness' is radically different from the classical
      understanding of ethics in the model of 'monological consciousness'. To reach
      accountable moral judgments, ethics cannot be conceptualized as an individual
      enterprise, but has to be seen as a practical endeavor embedded in social
      interactions within which moral understandings are being negotiated. This view
      has specific implications for the nature and the role of ethical theory. Theory
      is not created in the individual mind of the ethicist; the use of theory is part 
      of a joint learning process and embedded in a cultural context and social
      history. Theory is based upon practice, and serves practical purposes. Thus,
      clinical ethics support is both practical and theoretical.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Ohnsorge, Kathrin
AU  - Ohnsorge K
AD  - Department of Philosophy at the University of Basel, Switzerland.
      Kathrin.Ohnsorge@unibas.ch
FAU - Widdershoven, Guy
AU  - Widdershoven G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Aged
MH  - Anthropology, Cultural
MH  - *Ethical Theory
MH  - Ethicists
MH  - *Ethics Consultation
MH  - *Ethics, Clinical
MH  - Humans
MH  - Knowledge
MH  - Male
MH  - Models, Theoretical
MH  - Morals
MH  - Narration
MH  - Renal Dialysis/ethics
MH  - *Social Values
MH  - Withholding Treatment/ethics
EDAT- 2011/07/28 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/07/28 06:00
PHST- 2011/07/28 06:00 [entrez]
PHST- 2011/07/28 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 10.1111/j.1467-8519.2011.01912.x [doi]
PST - ppublish
SO  - Bioethics. 2011 Sep;25(7):361-9. doi: 10.1111/j.1467-8519.2011.01912.x.


PMID- 21790689
OWN - NLM
STAT- MEDLINE
DCOM- 20111209
LR  - 20110727
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 25
IP  - 7
DP  - 2011 Sep
TI  - Theory and practice of clinical ethics support services: narrative and
      hermeneutical perspectives.
PG  - 354-60
LID - 10.1111/j.1467-8519.2011.01911.x [doi]
AB  - In this paper we introduce narrative and hermeneutical perspectives to clinical
      ethics support services (CESS). We propose a threefold consideration of 'theory' 
      and show how it is interwoven with 'practice' as we go along. First, we look at
      theory in its foundational role: in our case 'narrative ethics' and
      'philosophical hermeneutics' provide a theoretical base for clinical ethics by
      focusing on human identities entangled in stories and on moral understanding as a
      dialogical process. Second, we consider the role of theoretical notions in
      helping practitioners to understand their situation in clinical ethics practice, 
      by using notions like 'story', 'responsibility', or 'vulnerability' to make
      explicit and explain their practical experience. Such theoretical notions help us
      to interpret clinical situations from an ethical perspective and to foster moral 
      awareness of practitioners. And, thirdly, we examine how new theoretical concepts
      are developed by interpreting practice, using practice to form and improve our
      ethical theory. In this paper, we discuss this threefold use of theory in
      clinical ethics support services by reflecting on our own theoretical
      assumptions, methodological steps and practical experiences as ethicists, and by 
      providing examples from our daily work. In doing so, we illustrate that theory
      and practice are interwoven, as theoretical understanding is dependent upon
      practical experience, and vice-versa.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Porz, Rouven
AU  - Porz R
AD  - Ethics Unit of the Bern University Hospital in Switzerland.
      RouvenChristian.Porz@insel.ch
FAU - Landeweer, Elleke
AU  - Landeweer E
FAU - Widdershoven, Guy
AU  - Widdershoven G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - *Ethical Analysis
MH  - *Ethical Theory
MH  - Ethicists
MH  - *Ethics Consultation
MH  - *Ethics, Clinical
MH  - Humans
MH  - *Narration
MH  - Professional Role
EDAT- 2011/07/28 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/07/28 06:00
PHST- 2011/07/28 06:00 [entrez]
PHST- 2011/07/28 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 10.1111/j.1467-8519.2011.01911.x [doi]
PST - ppublish
SO  - Bioethics. 2011 Sep;25(7):354-60. doi: 10.1111/j.1467-8519.2011.01911.x.


PMID- 21790688
OWN - NLM
STAT- MEDLINE
DCOM- 20111209
LR  - 20110727
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 25
IP  - 7
DP  - 2011 Sep
TI  - The practical importance of theory in clinical ethics support services.
PG  - ii-iii
LID - 10.1111/j.1467-8519.2011.01917.x [doi]
FAU - Molewijk, Bert
AU  - Molewijk B
FAU - Slowther, Anne
AU  - Slowther A
FAU - Aulisio, Mark
AU  - Aulisio M
LA  - eng
PT  - Editorial
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - *Ethical Theory
MH  - *Ethics Consultation
MH  - *Ethics, Clinical
MH  - Humans
EDAT- 2011/07/28 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/07/28 06:00
PHST- 2011/07/28 06:00 [entrez]
PHST- 2011/07/28 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 10.1111/j.1467-8519.2011.01917.x [doi]
PST - ppublish
SO  - Bioethics. 2011 Sep;25(7):ii-iii. doi: 10.1111/j.1467-8519.2011.01917.x.


PMID- 21790245
OWN - NLM
STAT- MEDLINE
DCOM- 20120702
LR  - 20220408
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Linking)
VI  - 12
IP  - 4
DP  - 2011
TI  - Prevalence of vitamin-mineral supplements use and associated factors among young 
      Malaysians.
PG  - 1023-9
AB  - The objective of this study is to determine the prevalence and associated factors
      of vitamin-mineral supplements use among Management and Science University
      students. The cross-sectional study protocol was approved by the Ethics and
      Research Committee and questionnaires were distributed randomly using simple
      random sampling to students from all faculties and consent was obtained. The data
      were analyzed using the SPSS version 13. Total number of the participants in this
      study is 105. More than half of them were female, older than 20 years of age and 
      Malay (58.1%, 61.9 and 61.9% respectively). The prevalence of vitamin-mineral
      supplement use was 43%, the main reasons being 'to maintain good health' 80%,
      followed by 'to ensure adequate nutrition' (10.5%). There was a significant
      positive association with monthly household income and BMI (P=0.039; P=0.048),
      with significant dependence on race and knowledge about vitamin-mineral
      supplements (P=0.002). There was a significant difference between medical and
      health sciences as compared to non-medical and health science faculties (p
      =0.05). The conclusion is that although the prevalence of vitamin-mineral
      supplement use among university students is relatively high, many of them do not 
      have accurate information about supplements. Therefore, there is a need to
      provide them with education and access to scientific and unbiased information.
FAU - Al-Naggar, Redhwan Ahmed
AU  - Al-Naggar RA
AD  - Community Medicine Department, International Medical School, Management and
      Science University, Shah Alam, Malaysia. radhwan888@yahoo.com
FAU - Chen, Robert
AU  - Chen R
LA  - eng
PT  - Journal Article
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
RN  - 0 (Minerals)
RN  - 0 (Vitamins)
SB  - IM
MH  - Adult
MH  - Cross-Sectional Studies/methods
MH  - Dietary Supplements/*statistics & numerical data
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Life Style
MH  - Malaysia
MH  - Male
MH  - Minerals/*administration & dosage
MH  - Nutritional Status
MH  - Prevalence
MH  - Social Class
MH  - Students/statistics & numerical data
MH  - Surveys and Questionnaires
MH  - Universities
MH  - Vitamins/*administration & dosage
MH  - Young Adult
EDAT- 2011/07/28 06:00
MHDA- 2012/07/03 06:00
CRDT- 2011/07/28 06:00
PHST- 2011/07/28 06:00 [entrez]
PHST- 2011/07/28 06:00 [pubmed]
PHST- 2012/07/03 06:00 [medline]
PST - ppublish
SO  - Asian Pac J Cancer Prev. 2011;12(4):1023-9.


PMID- 21789906
OWN - NLM
STAT- MEDLINE
DCOM- 20110825
LR  - 20110727
IS  - 1087-0652 (Print)
IS  - 1087-0652 (Linking)
VI  - 19
IP  - 8
DP  - 2011 Aug
TI  - Case management insider. Solution: committees on organizational ethics.
PG  - 119-21
FAU - Cesta, Toni
AU  - Cesta T
AD  - Lutheran Medical Center, Brooklyn, NY, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Hosp Case Manag
JT  - Hospital case management : the monthly update on hospital-based care planning and
      critical paths
JID - 9603097
MH  - Case Management/*ethics
MH  - Ethics Committees, Clinical/*organization & administration/standards
MH  - Humans
EDAT- 2011/07/28 06:00
MHDA- 2011/08/27 06:00
CRDT- 2011/07/28 06:00
PHST- 2011/07/28 06:00 [entrez]
PHST- 2011/07/28 06:00 [pubmed]
PHST- 2011/08/27 06:00 [medline]
PST - ppublish
SO  - Hosp Case Manag. 2011 Aug;19(8):119-21.


PMID- 21789905
OWN - NLM
STAT- MEDLINE
DCOM- 20110825
LR  - 20110727
IS  - 1087-0652 (Print)
IS  - 1087-0652 (Linking)
VI  - 19
IP  - 8
DP  - 2011 Aug
TI  - Case management insider. Every day, the case management department faces multiple
      dilemmas over ethics.
PG  - 118-9
FAU - Cesta, Toni
AU  - Cesta T
AD  - Lutheran Medical Center, Brooklyn, NY, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Hosp Case Manag
JT  - Hospital case management : the monthly update on hospital-based care planning and
      critical paths
JID - 9603097
MH  - Case Management/*ethics
MH  - Decision Making/ethics
MH  - *Ethics, Institutional
MH  - Humans
EDAT- 2011/07/28 06:00
MHDA- 2011/08/27 06:00
CRDT- 2011/07/28 06:00
PHST- 2011/07/28 06:00 [entrez]
PHST- 2011/07/28 06:00 [pubmed]
PHST- 2011/08/27 06:00 [medline]
PST - ppublish
SO  - Hosp Case Manag. 2011 Aug;19(8):118-9.


PMID- 21789700
OWN - NLM
STAT- MEDLINE
DCOM- 20120716
LR  - 20211020
IS  - 1433-8491 (Electronic)
IS  - 0940-1334 (Linking)
VI  - 262
IP  - 2
DP  - 2012 Mar
TI  - Critical trial-related criteria in acute schizophrenia studies.
PG  - 151-5
LID - 10.1007/s00406-011-0225-3 [doi]
AB  - The Trial Criteria in Schizophrenia Working Group was convened in November 2007
      to define consensus criteria for clinical trials in patients suffering from acute
      schizophrenia with special focus on placebo-controlled trials and withdrawal
      conditions. Clinical trials involving patients give rise to ethical and
      medico-legal dilemmas. Essential research of new drugs may potentially expose
      patients to ineffective treatment regimens or placebo. The complexity of the
      problem increases when dealing with mentally ill patients. The Working Group's
      criteria are thought to cover different aspects important in conducting clinical 
      trials namely to ensure the patient's safety, to present criteria that would
      allow the ethics committees to agree to the proposed criteria and to enable the
      possibility to reasonably conduct and ensure comparable quality of clinical
      studies in acutely ill patients with schizophrenia. To furthermore counteract
      current inconsistencies, these criteria should be evaluated using standardized
      rating scales applying established cut-off criteria. The developed trial criteria
      cover inclusion and exclusion criteria as well as withdrawal criteria due to
      non-response or worsening of symptoms.
FAU - Riedel, Michael
AU  - Riedel M
AD  - Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich,
      Nussbaumstrasse 7, 80336, Munich, Munchen, Germany. riedel@med.uni-muenchen.de
FAU - Leucht, Stefan
AU  - Leucht S
FAU - Ruther, Eckart
AU  - Ruther E
FAU - Schmauss, Max
AU  - Schmauss M
FAU - Moller, Hans-Jurgen
AU  - Moller HJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110726
PL  - Germany
TA  - Eur Arch Psychiatry Clin Neurosci
JT  - European archives of psychiatry and clinical neuroscience
JID - 9103030
RN  - 0 (Placebos)
SB  - IM
MH  - Acute Disease
MH  - Clinical Trials as Topic/ethics/*standards
MH  - Humans
MH  - Placebos
MH  - Research Design/*standards
MH  - Schizophrenia/*therapy
EDAT- 2011/07/27 06:00
MHDA- 2012/07/17 06:00
CRDT- 2011/07/27 06:00
PHST- 2011/03/19 00:00 [received]
PHST- 2011/07/09 00:00 [accepted]
PHST- 2011/07/27 06:00 [entrez]
PHST- 2011/07/27 06:00 [pubmed]
PHST- 2012/07/17 06:00 [medline]
AID - 10.1007/s00406-011-0225-3 [doi]
PST - ppublish
SO  - Eur Arch Psychiatry Clin Neurosci. 2012 Mar;262(2):151-5. doi:
      10.1007/s00406-011-0225-3. Epub 2011 Jul 26.


PMID- 21789590
OWN - NLM
STAT- MEDLINE
DCOM- 20130213
LR  - 20211020
IS  - 1436-3771 (Electronic)
IS  - 1432-6981 (Linking)
VI  - 16
IP  - 4
DP  - 2012 Aug
TI  - Comparison of two all-in-one adhesives bonded to non-carious cervical
      lesions--results at 3 years.
PG  - 1089-94
LID - 10.1007/s00784-011-0595-y [doi]
AB  - The aim of this study was to evaluate the clinical performance of S(3) Bond
      (Kuraray Corp., Japan) and G-Bond (GC Corp., Japan) all-in-one bonding agents,
      over 3 years in non-carious cervical lesions (NCCLs). Ethics Committee approval
      was obtained, and 60 restorations were placed in 11 patients aged 45-84 years
      (mean 60.5 years), using either Clearfil ST resin composite (Kuraray) and S(3)
      Bond or Gradia resin composite (GC) and G-Bond alternately, without phosphoric
      acid etch on the uncut enamel margins. Patients were recalled at 6 months, 1
      year, 2 years and 3 years, and photographs were taken for assessment of colour
      match and marginal discoloration. One patient was not available at 3 years,
      resulting in 54 restorations being available for evaluation. One restoration of
      S(3)/Clearfil ST was lost at 2 years, giving retention rates of 97% for S(3) and 
      100% for G-Bond. At 3 years, six restorations for S(3)/Clearfil ST showed slight 
      marginal discoloration and one restoration pronounced marginal staining. For
      G-Bond/Gradia at 3 years, 11 restorations exhibited slight marginal staining and 
      one restoration pronounced marginal staining. Most restorations were bonded to
      sclerotic dentin. Statistical analysis of marginal staining showed no significant
      difference between the two restoration groups. The degree of marginal staining
      was almost identical for both materials and tended to be in larger restorations. 
      Both S(3) and G-Bond all-in-one bonding systems appear to be good adhesives for
      the restoration of NCCL for the length of the current study. Restoration of NCCLs
      with the newer all-in-one adhesives appears to be a viable alternative technique 
      to more complicated adhesive materials.
FAU - Burrow, Michael F
AU  - Burrow MF
AD  - Faculty of Dentistry, University of Hong Kong, 34 Hospital Road, Sai Ying Pun,
      Hong Kong. mfburr58@hku.hk
FAU - Tyas, Martin J
AU  - Tyas MJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110726
PL  - Germany
TA  - Clin Oral Investig
JT  - Clinical oral investigations
JID - 9707115
RN  - 0 (Clearfil S3 Bond)
RN  - 0 (Clearfil ST)
RN  - 0 (Composite Resins)
RN  - 0 (Dental Materials)
RN  - 0 (Dentin-Bonding Agents)
RN  - 0 (G-Bond)
RN  - 0 (Gradia)
RN  - 0 (Methacrylates)
RN  - 0 (Resin Cements)
MH  - Aged
MH  - Aged, 80 and over
MH  - Color
MH  - Composite Resins/chemistry
MH  - *Dental Bonding
MH  - Dental Materials/chemistry
MH  - Dental Polishing/methods
MH  - Dental Prosthesis Retention
MH  - Dental Restoration Failure
MH  - Dental Restoration, Permanent/*methods
MH  - Dentin, Secondary/pathology
MH  - Dentin-Bonding Agents/*chemistry
MH  - Follow-Up Studies
MH  - Humans
MH  - Light-Curing of Dental Adhesives/methods
MH  - Methacrylates/chemistry
MH  - Middle Aged
MH  - Photography, Dental
MH  - Resin Cements/chemistry
MH  - Surface Properties
MH  - Tooth Cervix/*pathology
MH  - Tooth Wear/*therapy
EDAT- 2011/07/27 06:00
MHDA- 2013/02/14 06:00
CRDT- 2011/07/27 06:00
PHST- 2010/12/09 00:00 [received]
PHST- 2011/07/14 00:00 [accepted]
PHST- 2011/07/27 06:00 [entrez]
PHST- 2011/07/27 06:00 [pubmed]
PHST- 2013/02/14 06:00 [medline]
AID - 10.1007/s00784-011-0595-y [doi]
PST - ppublish
SO  - Clin Oral Investig. 2012 Aug;16(4):1089-94. doi: 10.1007/s00784-011-0595-y. Epub 
      2011 Jul 26.


PMID- 21789460
OWN - NLM
STAT- MEDLINE
DCOM- 20111213
LR  - 20191112
IS  - 1809-4546 (Electronic)
IS  - 0100-6991 (Linking)
VI  - 38
IP  - 3
DP  - 2011 May-Jun
TI  - [Informed consent: what is it real value in medical practice?].
PG  - 198-201
LID - S0100-69912011000300011 [pii]
AB  - This is an article that talks about the real importance of Informed Consent (IC) 
      in medical practice. This document has been increasingly used as a defensive
      practice, in order to provide evidence to the defense of any lawsuit of medical
      responsibility, thus distorting the original idea, which would be to respect
      patient autonomy and delimit medical liability. The document aims to show that
      the doctor complied with his duty to inform. Its great value lies in cases where 
      there is a risk of irreversible damage to the patient. We conclude, however, that
      a well-documented chart, which includes the recording of information that was
      provided and the degree of participation of patients and their families in
      treatment decisions, should also have legal and ethical value similar to the
      IC's.
FAU - Minossi, Jose Guilherme
AU  - Minossi JG
AD  - Departamento de Cirurgia e Ortopedia, Faculdade de Medicina de Botucatu, Unesp,
      SP, BR. jminossi@uol.com.br
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - O consentimento informado: qual o seu real valor na pratica medica?
PL  - Brazil
TA  - Rev Col Bras Cir
JT  - Revista do Colegio Brasileiro de Cirurgioes
JID - 7809515
SB  - IM
MH  - Ethics, Medical
MH  - Humans
MH  - *Informed Consent
EDAT- 2011/07/27 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/07/27 06:00
PHST- 2010/10/11 00:00 [received]
PHST- 2010/11/16 00:00 [accepted]
PHST- 2011/07/27 06:00 [entrez]
PHST- 2011/07/27 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - S0100-69912011000300011 [pii]
AID - 10.1590/s0100-69912011000300011 [doi]
PST - ppublish
SO  - Rev Col Bras Cir. 2011 May-Jun;38(3):198-201. doi:
      10.1590/s0100-69912011000300011.


PMID- 21788961
OWN - NLM
STAT- MEDLINE
DCOM- 20120328
LR  - 20220316
IS  - 1759-5010 (Electronic)
IS  - 1759-5002 (Linking)
VI  - 8
IP  - 12
DP  - 2011 Jul 26
TI  - Effective communication and ethical consent in decisions related to ICDs.
PG  - 694-705
LID - 10.1038/nrcardio.2011.101 [doi]
AB  - This Review examines recommendations and principles that promote good
      decision-making with regard to the insertion, deactivation, and potential
      malfunction of implantable cardioverter-defibrillators (ICDs). This guidance is
      important because ICDs are now used for primary and secondary prevention of
      arrhythmias in more than 20 diverse clinical populations, which accounts for the 
      exponential increase in insertion rates over the past decade. Current guidelines 
      require clinicians to provide personalized, culturally appropriate, and easy to
      understand information to patients on the benefits and harms of proposed
      treatment choices; however, obtaining valid informed consent for insertion and
      deactivation of ICDs is challenging. Initiating early conversations with patients
      and continuing this dialogue over time, implementation of localized care
      protocols, increased collaboration (particularly between cardiac and palliative
      care teams), and the provision of training for all health professionals involved 
      in the care of these patients, can help to ensure that adequate informed consent 
      is maintained throughout their care. In addition to providing information, health
      professionals should identify and address high levels of anxiety in patients and 
      their next of kin and promote effective communication throughout decision making.
      In the future, use of standardized checklists or decision aids based on a clear
      understanding of the principles underlying key topics could support this process.
FAU - Clark, Alexander M
AU  - Clark AM
AD  - Faculty of Nursing, University of Alberta, Level 3 CSB, Edmonton, AB TG3 2G3,
      Canada. alex.clark@ualberta.ca
FAU - Jaarsma, Tiny
AU  - Jaarsma T
FAU - Strachan, Patricia
AU  - Strachan P
FAU - Davidson, Patricia M
AU  - Davidson PM
FAU - Jerke, Megan
AU  - Jerke M
FAU - Beattie, James M
AU  - Beattie JM
FAU - Duncan, Amanda S
AU  - Duncan AS
FAU - Ski, Chantal F
AU  - Ski CF
FAU - Thompson, David R
AU  - Thompson DR
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110726
PL  - England
TA  - Nat Rev Cardiol
JT  - Nature reviews. Cardiology
JID - 101500075
SB  - IM
MH  - Attitude of Health Personnel
MH  - Benchmarking/ethics
MH  - *Communication
MH  - Defibrillators, Implantable/adverse effects/*ethics
MH  - Device Removal/*ethics/legislation & jurisprudence
MH  - Electric Countershock/adverse effects/*ethics/instrumentation
MH  - Equipment Failure
MH  - Evidence-Based Medicine/ethics
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Informed Consent/*ethics/legislation & jurisprudence
MH  - Patient Education as Topic
MH  - *Patient Participation/legislation & jurisprudence
MH  - Patient Selection/ethics
MH  - Physician-Patient Relations/*ethics
MH  - Practice Guidelines as Topic
MH  - Risk Assessment
EDAT- 2011/07/27 06:00
MHDA- 2012/03/29 06:00
CRDT- 2011/07/27 06:00
PHST- 2011/07/27 06:00 [entrez]
PHST- 2011/07/27 06:00 [pubmed]
PHST- 2012/03/29 06:00 [medline]
AID - nrcardio.2011.101 [pii]
AID - 10.1038/nrcardio.2011.101 [doi]
PST - epublish
SO  - Nat Rev Cardiol. 2011 Jul 26;8(12):694-705. doi: 10.1038/nrcardio.2011.101.


PMID- 21788905
OWN - NLM
STAT- MEDLINE
DCOM- 20120305
LR  - 20151119
IS  - 1536-0210 (Electronic)
IS  - 0020-9996 (Linking)
VI  - 46
IP  - 11
DP  - 2011 Nov
TI  - Near-infrared imaging of the breast using omocianine as a fluorescent dye:
      results of a placebo-controlled, clinical, multicenter trial.
PG  - 697-704
LID - 10.1097/RLI.0b013e318229ff25 [doi]
AB  - OBJECTIVES: To evaluate the efficacy of the near-infrared (NIR) dye Omocianine in
      a placebo-controlled, dose-escalating multicenter trial for the detection of
      malignant breast lesions by using a NIR imaging system. MATERIALS AND METHODS:
      The study was approved by the ethical review board of Berlin and Munster,, and
      all participants provided written informed consent. Fifty-two consecutive
      patients were examined with NIR imaging before, during, and after intravenous
      injection of Omocianine. Three-dimensional absorption and fluorescence diffuse
      optical tomography scans were recorded simultaneously on a prototype NIR imaging 
      unit (Computed Tomography Laser Mammography, Imaging Diagnostic Systems, Inc.,
      Ft. Lauderdale, FL). Two readers assessed the images in consensus and assigned
      visibility scores to lesions seen on the absorption and absorption-corrected
      fluorescence diffuse optical tomography mammograms. Imaging results were compared
      with histopathologic findings. To analyze whether lesion detection rate for
      malignant lesions depended on the size of the lesion, lesions were dichotomized
      into those measuring less than 20 mm and those measuring 20 mm or more. Moreover,
      the shortest diameter between the center of the target lesions and the skin was
      measured on axial optical mammography data. RESULTS: There were a total of 53
      target lesions. Histopathologically, 22 target lesions were diagnosed as benign
      and 31 target lesions as malignant. In the absorption mode, a detection rate of
      11.8% for benign and 44.4% for malignant lesions across all dose groups was
      found. In the fluorescence mode, a detection rate of 17.6% was revealed for
      benign and 55.6% for malignant lesions across all dose groups. For dose group 0.1
      mg/kg, a detection rate of 100% was found for malignant lesions in the
      fluorescence mode and 71.4% in the absorption mode. Across all dose groups in the
      fluorescence mode, detection rate for malignant target lesions in breasts smaller
      than the median axial breast diameter of 12.8 cm was higher with 69.2% than in
      median diameters >/= 12.8 cm with 46.2%. Omocianine-enhanced fluorescence optical
      mammography allowed a better detection of more superficially located lesions,
      with detection rates for a lesion-skin distance <20 mm of 63.6%, for <30 mm of
      47.4% and for >/= 30 mm of 25%. Malignant target lesions with a diameter >/= 20
      mm were slightly better detected with 61.5% in contrast to suspicious lesions <20
      mm with 53.8%. Optimal imaging time points varied strongly among the different
      target lesions and Omocianine dose groups, with a mean optimal time point for
      malignant lesions at 188 +/- 385 minutes. CONCLUSION: Preliminary data suggest
      that fluorescence imaging after Omocianine administration has the potential to
      detect malignant breast lesions. As our study showed considerable variations in
      the detection of breast cancer at different fluorophore concentrations ranging
      from 20% to 100%, future work needs to be done to assess the suitable dose for
      NIR imaging.
FAU - Poellinger, Alexander
AU  - Poellinger A
AD  - Department of Radiology, Campus Charite Virchow Klinikum, Berlin, Germany.
      alexander.poellinger@charite.de
FAU - Persigehl, Thorsten
AU  - Persigehl T
FAU - Mahler, Marianne
AU  - Mahler M
FAU - Bahner, Malte
AU  - Bahner M
FAU - Ponder, Steven L
AU  - Ponder SL
FAU - Diekmann, Felix
AU  - Diekmann F
FAU - Bremer, Christoph
AU  - Bremer C
FAU - Moesta, Thomas
AU  - Moesta T
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PL  - United States
TA  - Invest Radiol
JT  - Investigative radiology
JID - 0045377
RN  - 0 (Carbocyanines)
RN  - 0 (Fluorescent Dyes)
RN  - 0 (Indoles)
RN  - 0 (Placebos)
RN  - 5GD5D29K7I (omocianine)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Breast Neoplasms/*diagnosis/pathology
MH  - *Carbocyanines
MH  - Female
MH  - *Fluorescent Dyes
MH  - Germany
MH  - Humans
MH  - Image Enhancement/methods
MH  - Image Interpretation, Computer-Assisted/methods
MH  - *Indoles
MH  - Infrared Rays
MH  - Lasers
MH  - Magnetic Resonance Imaging
MH  - Mammography
MH  - Middle Aged
MH  - Pattern Recognition, Automated/methods
MH  - Placebos
MH  - Tomography, Optical/*methods
EDAT- 2011/07/27 06:00
MHDA- 2012/03/06 06:00
CRDT- 2011/07/27 06:00
PHST- 2011/07/27 06:00 [entrez]
PHST- 2011/07/27 06:00 [pubmed]
PHST- 2012/03/06 06:00 [medline]
AID - 10.1097/RLI.0b013e318229ff25 [doi]
PST - ppublish
SO  - Invest Radiol. 2011 Nov;46(11):697-704. doi: 10.1097/RLI.0b013e318229ff25.


PMID- 21788401
OWN - NLM
STAT- MEDLINE
DCOM- 20111201
LR  - 20110726
IS  - 1546-8364 (Electronic)
IS  - 1059-8405 (Linking)
VI  - 27
IP  - 4
DP  - 2011 Aug
TI  - Ethical treatment of school children in research: assuring informed consent.
PG  - 247-8
LID - 10.1177/1059840511414384 [doi]
FAU - Cowell, Julia Muennich
AU  - Cowell JM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Sch Nurs
JT  - The Journal of school nursing : the official publication of the National
      Association of School Nurses
JID - 9206498
MH  - Child
MH  - Child Welfare/*ethics
MH  - Ethics, Medical
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Interpersonal Relations
MH  - Parental Consent/*ethics
MH  - Parents/education
MH  - *Personal Autonomy
MH  - United States
EDAT- 2011/07/27 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/27 06:00
PHST- 2011/07/27 06:00 [entrez]
PHST- 2011/07/27 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 27/4/247 [pii]
AID - 10.1177/1059840511414384 [doi]
PST - ppublish
SO  - J Sch Nurs. 2011 Aug;27(4):247-8. doi: 10.1177/1059840511414384.


PMID- 21788290
OWN - NLM
STAT- MEDLINE
DCOM- 20111201
LR  - 20110726
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 4
DP  - 2011 Jul
TI  - Cultural competence: reflections on patient autonomy and patient good.
PG  - 560-70
LID - 10.1177/0969733011405936 [doi]
AB  - Terms such as 'cultural competence' and 'transcultural nursing' have comfortably 
      taken their place in the lexicon of health care. Their high profile is a
      reflection of the diversity of western societies and health care's commitment to 
      provide care that is responsive to the values and beliefs of all who require
      treatment. However, the relationship between cultural competence and familiar
      ethical concepts such as patient autonomy has been an uneasy one. This article
      explores the moral foundations of cultural competence, ultimately locating them
      in patient autonomy and patient good. The discussion of patient good raises
      questions about the moral relevance of a value's rootedness in a particular
      culture. I argue that the moral justification for honoring cultural values has
      more to do with the fact that patients are strongly committed to them than it
      does with their cultural rootedness. Finally, I suggest an organizational
      approach to cultural competence that emphasizes overall organizational
      preparedness.
FAU - Leever, Martin G
AU  - Leever MG
AD  - University of Detroit Mercy, Detroit, Michigan 48221-3038, USA.
      leevermg@udmercy.edu
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Cultural Characteristics
MH  - *Cultural Competency/organization & administration
MH  - Humans
MH  - Morals
MH  - Nurse-Patient Relations/*ethics
MH  - *Personal Autonomy
MH  - Social Values
MH  - *Transcultural Nursing
EDAT- 2011/07/27 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/27 06:00
PHST- 2011/07/27 06:00 [entrez]
PHST- 2011/07/27 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 18/4/560 [pii]
AID - 10.1177/0969733011405936 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Jul;18(4):560-70. doi: 10.1177/0969733011405936.


PMID- 21788289
OWN - NLM
STAT- MEDLINE
DCOM- 20111201
LR  - 20110726
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 4
DP  - 2011 Jul
TI  - The hierarchy of values in Jewish bioethics.
PG  - 537-47
LID - 10.1177/0969733011403558 [doi]
AB  - This article describes how ethical issues in health are approached and resolved
      within the framework of Jewish bioethics. Its main purpose is to explore the
      range of sources and methodologies used to determine the appropriate hierarchy of
      values for various ethical scenarios. Its major thrust is to illustrate how a
      divinely based but humanly negotiated ethical code stands firm upon 'red flag'
      principles, while at the same time, allowing for 'shades of gray' flexibility
      informed by given contexts. It provides significant insights and practical tools 
      that can be instrumental in decision making for nurses and other health providers
      of all faiths. The following ethical domains are addressed: respect for patient
      autonomy, truth-telling and allocation of resources.
FAU - Greenberger, Chaya
AU  - Greenberger C
AD  - Department head, Nursing,Jerusalem College of Technology, Jerusalem, Israel.
      greenber@jct.ac.il
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - *Bioethical Issues
MH  - Codes of Ethics
MH  - Humans
MH  - *Judaism
MH  - Personal Autonomy
MH  - *Religion and Medicine
MH  - Resource Allocation
MH  - *Social Values
MH  - Truth Disclosure
EDAT- 2011/07/27 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/27 06:00
PHST- 2011/07/27 06:00 [entrez]
PHST- 2011/07/27 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 18/4/537 [pii]
AID - 10.1177/0969733011403558 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Jul;18(4):537-47. doi: 10.1177/0969733011403558.


PMID- 21788288
OWN - NLM
STAT- MEDLINE
DCOM- 20111201
LR  - 20110726
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 4
DP  - 2011 Jul
TI  - Citizenship and autonomy in acquired brain injury.
PG  - 526-36
LID - 10.1177/0969733011403554 [doi]
AB  - In ethical theory, different concepts of autonomy can be distinguished. In this
      article we explore how these concepts of autonomy are combined in theory in the
      citizenship paradigm, and how this turns out in the practice of care for people
      with acquired brain injury. The stories of a professional caregiver and a client 
      with acquired brain injury show that the combination of various concepts of
      autonomy in practice leads to tensions between caregivers and clients. These
      dynamics are discussed from a care ethics perspective, stressing the importance
      of relationships and interdependence, as well as paying attention to various,
      sometimes conflicting, perspectives in a deliberative dialogue.
FAU - Schipper, Karen
AU  - Schipper K
AD  - Department of Medical Humanities, VU University Medical Center, The Netherlands
      Reinaerde, Amsterdam, The Netherlands. k.schipper@vumc.nl
FAU - Widdershoven, Guy A M
AU  - Widdershoven GA
FAU - Abma, Tineke A
AU  - Abma TA
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Brain Injuries/*nursing
MH  - Ethical Theory
MH  - *Ethics, Nursing
MH  - Humans
MH  - *Nurse-Patient Relations
MH  - *Professional Autonomy
MH  - Qualitative Research
EDAT- 2011/07/27 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/27 06:00
PHST- 2011/07/27 06:00 [entrez]
PHST- 2011/07/27 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 18/4/526 [pii]
AID - 10.1177/0969733011403554 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Jul;18(4):526-36. doi: 10.1177/0969733011403554.


PMID- 21788287
OWN - NLM
STAT- MEDLINE
DCOM- 20111201
LR  - 20110726
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 4
DP  - 2011 Jul
TI  - Futile cardiopulmonary resuscitation for the benefit of others: an ethical
      analysis.
PG  - 495-504
LID - 10.1177/0969733011404339 [doi]
AB  - It has been reported as an ethical problem within prehospital emergency care that
      ambulance professionals administer physiologically futile cardiopulmonary
      resuscitation (CPR) to patients having suffered cardiac arrest to benefit
      significant others. At the same time it is argued that, under certain
      circumstances, this is an acceptable moral practice by signalling that everything
      possible has been done, and enabling the grief of significant others to be
      properly addressed. Even more general moral reasons have been used to morally
      legitimize the use of futile CPR: That significant others are a type of patient
      with medical or care needs that should be addressed, that the interest of
      significant others should be weighed into what to do and given an equal standing 
      together with patient interests, and that significant others could be benefited
      by care professionals unless it goes against the explicit wants of the patient.
      In this article we explore these arguments and argue that the support for
      providing physiologically futile CPR in the prehospital context fails. Instead,
      the strategy of ambulance professionals in the case of a sudden death should be
      to focus on the relevant care needs of the significant others and provide
      support, arrange for a peaceful environment and administer acute grief
      counselling at the scene, which might call for a developed competency within this
      field.
FAU - Bremer, Anders
AU  - Bremer A
AD  - University of Boras, Boras, Sweden. anders.bremer@hb.se
FAU - Sandman, Lars
AU  - Sandman L
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Ambulances
MH  - *Cardiopulmonary Resuscitation
MH  - Emergency Medical Services/*ethics
MH  - Emergency Medical Technicians
MH  - Ethical Analysis
MH  - Heart Arrest/*therapy
MH  - Humans
MH  - Interpersonal Relations
MH  - *Medical Futility
EDAT- 2011/07/27 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/27 06:00
PHST- 2011/07/27 06:00 [entrez]
PHST- 2011/07/27 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 18/4/495 [pii]
AID - 10.1177/0969733011404339 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Jul;18(4):495-504. doi: 10.1177/0969733011404339.


PMID- 21788223
OWN - NLM
STAT- MEDLINE
DCOM- 20111013
LR  - 20151018
IS  - 1098-4275 (Electronic)
IS  - 0031-4005 (Linking)
VI  - 128
IP  - 2
DP  - 2011 Aug
TI  - Maternal-fetal intervention and fetal care centers.
PG  - e473-8
LID - 10.1542/peds.2011-1570 [doi]
AB  - The past 2 decades have yielded profound advances in the fields of prenatal
      diagnosis and fetal intervention. Although fetal interventions are driven by a
      beneficence-based motivation to improve fetal and neonatal outcomes, advancement 
      in fetal therapies raises ethical issues surrounding maternal autonomy and
      decision-making, concepts of innovation versus research, and organizational
      aspects within institutions in the development of fetal care centers. To
      safeguard the interests of both the pregnant woman and the fetus, the American
      College of Obstetricians and Gynecologists and the American Academy of Pediatrics
      make recommendations regarding informed consent, the role of research subject
      advocates and other independent advocates, the availability of support services, 
      the multidisciplinary nature of fetal intervention teams, the oversight of
      centers, and the need to accumulate maternal and fetal outcome data.
CN  - American College of Obstetricians and Gynecologists, Committee on Ethics
CN  - American Academy of Pediatrics, Committee on Bioethics
LA  - eng
PT  - Journal Article
DEP - 20110725
PL  - United States
TA  - Pediatrics
JT  - Pediatrics
JID - 0376422
SB  - IM
MH  - Academies and Institutes/*ethics/standards
MH  - Bioethical Issues/standards
MH  - Decision Making
MH  - Female
MH  - *Fetal Diseases/diagnosis/therapy
MH  - Gynecology/*ethics/standards
MH  - Humans
MH  - *Maternal-Fetal Relations
MH  - Obstetrics/*ethics/standards
MH  - Pediatrics/*ethics/standards
MH  - Pregnancy
MH  - United States
IR  - Diekem DS
FIR - Diekem, Douglas S
IR  - Fallat ME
FIR - Fallat, Mary E
IR  - Antommaria AH
FIR - Antommaria, Armand H Matheny
IR  - Holzman IR
FIR - Holzman, Ian R
IR  - Katz AL
FIR - Katz, Aviva L
IR  - Leuthner SR
FIR - Leuthner, Steven R
IR  - Ross LF
FIR - Ross, Lainie Friedman
IR  - Webb SA
FIR - Webb, Sally A
IR  - Weise KL
FIR - Weise, Kathryn L
IR  - Ralston SJ
FIR - Ralston, Steven J
IR  - Lyerly AD
FIR - Lyerly, Anne D
IR  - Bernstein J
FIR - Bernstein, Judith
IR  - Brincat CA
FIR - Brincat, Cynthia A
IR  - Burda ML
FIR - Burda, Marianne L
IR  - Childress JF
FIR - Childress, James F
IR  - Farrell RM
FIR - Farrell, Ruth M
IR  - Frederickson HL
FIR - Frederickson, Helen L
IR  - Kroncke FG Jr
FIR - Kroncke, Frederick G Jr
IR  - Marshall MF
FIR - Marshall, Mary Faith
IR  - Minkoff HL
FIR - Minkoff, Howard L
IR  - Ramondetta LM
FIR - Ramondetta, Lois M
IR  - Spillman MA
FIR - Spillman, Monique A
IR  - Werden JJ
FIR - Werden, Joelene J S
EDAT- 2011/07/27 06:00
MHDA- 2011/10/14 06:00
CRDT- 2011/07/27 06:00
PHST- 2011/07/27 06:00 [entrez]
PHST- 2011/07/27 06:00 [pubmed]
PHST- 2011/10/14 06:00 [medline]
AID - peds.2011-1570 [pii]
AID - 10.1542/peds.2011-1570 [doi]
PST - ppublish
SO  - Pediatrics. 2011 Aug;128(2):e473-8. doi: 10.1542/peds.2011-1570. Epub 2011 Jul
      25.


PMID- 21787446
OWN - NLM
STAT- MEDLINE
DCOM- 20120801
LR  - 20151119
IS  - 1477-1128 (Electronic)
IS  - 1463-4236 (Linking)
VI  - 13
IP  - 2
DP  - 2012 Apr
TI  - Autogenic Training as a behavioural approach to insomnia: a prospective cohort
      study.
PG  - 175-85
LID - 10.1017/S1463423611000181 [doi]
AB  - BACKGROUND: Insomnia is commonly associated with chronic health problems.
      Behavioural and cognitive factors often perpetuate a vicious cycle of anxiety and
      sleep disturbance, leading to long-term insomnia. National Institute for Health
      and Clinical Excellence currently recommends behavioural approaches before
      prescribing hypnotics. Behavioural approaches aim to treat underlying causes, but
      are not widely available. Research usually includes patients diagnosed with
      insomnia rather than secondary, co-morbid sleep- related problems. AIM: To
      examine the effectiveness of autogenic training (AT) as a non-drug approach to
      sleep-related problems associated with chronic ill health. DESIGN: Prospective
      pre- and post-treatment cohort study. SETTING: AT centre, Royal London Hospital
      for Integrated Medicine, University College London Hospitals NHS Foundation
      Trust. METHODS: All patients referred for AT from April 2007 to April 2008 were
      invited to participate. Participants received standard 8-week training, with no
      specific focus on sleep. Sleep questionnaires were administered at four time
      points, 'Measure Your Medical Outcome Profile' (MYMOP) and Hospital Anxiety and
      Depression Scale, before and after treatment. Results before and after treatment 
      were compared. Camden and Islington Community Local Research and Ethics Committee
      approved the study. RESULTS: The AT course was completed by 153 participants, of 
      whom 73% were identified as having a sleep-related problem. Improvements in sleep
      patterns included: sleep onset latency (P = 0.049), falling asleep quicker after 
      night waking (P < 0.001), feeling more refreshed (P < 0.001) and more energised
      on waking (P = 0.019). MYMOP symptom, well-being, anxiety and depression scores
      significantly improved (all P < 0.001). CONCLUSION: This study suggests that AT
      may improve sleep patterns for patients with various health conditions and reduce
      anxiety and depression, both of which may result from and cause insomnia.
      Improvements in sleep patterns occurred despite, or possibly due to, not focusing
      on sleep during training. AT may provide an approach to insomnia that could be
      incorporated into primary care.
FAU - Bowden, Ann
AU  - Bowden A
AD  - Royal London Hospital for Integrated Medicine, University College London
      Hospitals, London, UK. ann.bowden@uclh.nhs.uk
FAU - Lorenc, Ava
AU  - Lorenc A
FAU - Robinson, Nicola
AU  - Robinson N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110726
PL  - England
TA  - Prim Health Care Res Dev
JT  - Primary health care research & development
JID - 100897390
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Autogenic Training
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Sleep Initiation and Maintenance Disorders/psychology/*therapy
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2011/07/27 06:00
MHDA- 2012/08/02 06:00
CRDT- 2011/07/27 06:00
PHST- 2011/07/27 06:00 [entrez]
PHST- 2011/07/27 06:00 [pubmed]
PHST- 2012/08/02 06:00 [medline]
AID - S1463423611000181 [pii]
AID - 10.1017/S1463423611000181 [doi]
PST - ppublish
SO  - Prim Health Care Res Dev. 2012 Apr;13(2):175-85. doi: 10.1017/S1463423611000181. 
      Epub 2011 Jul 26.


PMID- 21787442
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111123
LR  - 20211020
IS  - 1756-994X (Electronic)
IS  - 1756-994X (Linking)
VI  - 3
IP  - 7
DP  - 2011 Jul 14
TI  - Towards a data sharing Code of Conduct for international genomic research.
PG  - 46
LID - 10.1186/gm262 [doi]
AB  - Data sharing is increasingly regarded as an ethical and scientific imperative
      that advances knowledge and thereby respects the contributions of the
      participants. Because of this and the ever-increasing amount of data access
      requests currently filed around the world, three groups have decided to develop
      data sharing principles specific to the context of collaborative international
      genomics research. These groups are: the international Public Population Project 
      in Genomics (P3G), an international consortium of projects partaking in
      large-scale genetic epidemiological studies and biobanks; the European Network
      for Genetic and Genomic Epidemiology (ENGAGE), a research project aiming to
      translate data from large-scale epidemiological research initiatives into
      relevant clinical information; and the Centre for Health, Law and Emerging
      Technologies (HeLEX). We propose seven different principles and a preliminary
      international data sharing Code of Conduct for ongoing discussion.
FAU - Knoppers, Bartha Maria
AU  - Knoppers BM
AD  - Department of Human Genetics, McGill University, 740 Dr Penfield Avenue,
      Montreal, Quebec H3A 1A4, Canada. bartha.knoppers@mcgill.ca.
FAU - Harris, Jennifer R
AU  - Harris JR
FAU - Tasse, Anne Marie
AU  - Tasse AM
FAU - Budin-Ljosne, Isabelle
AU  - Budin-Ljosne I
FAU - Kaye, Jane
AU  - Kaye J
FAU - Deschenes, Mylene
AU  - Deschenes M
FAU - Zawati, Ma'n H
AU  - Zawati MH
LA  - eng
GR  - 096599/Wellcome Trust/United Kingdom
PT  - Journal Article
DEP - 20110714
PL  - England
TA  - Genome Med
JT  - Genome medicine
JID - 101475844
PMC - PMC3221544
EDAT- 2011/07/27 06:00
MHDA- 2011/07/27 06:01
CRDT- 2011/07/27 06:00
PHST- 2011/07/27 06:00 [entrez]
PHST- 2011/07/27 06:00 [pubmed]
PHST- 2011/07/27 06:01 [medline]
AID - gm262 [pii]
AID - 10.1186/gm262 [doi]
PST - epublish
SO  - Genome Med. 2011 Jul 14;3(7):46. doi: 10.1186/gm262.


PMID- 21787188
OWN - NLM
STAT- MEDLINE
DCOM- 20111123
LR  - 20161125
IS  - 1744-8042 (Electronic)
IS  - 1462-2416 (Linking)
VI  - 12
IP  - 7
DP  - 2011 Jul
TI  - Prospective-retrospective biomarker analysis for regulatory consideration: white 
      paper from the industry pharmacogenomics working group.
PG  - 939-51
LID - 10.2217/pgs.11.52 [doi]
AB  - One approach to delivering cost-effective healthcare requires the identification 
      of patients as individuals or subpopulations that are more likely to respond to
      an appropriate dose and/or schedule of a therapeutic agent, or as subpopulations 
      that are less likely to develop an adverse event (i.e., personalized or
      stratified medicine). Biomarkers that identify therapeutically relevant
      variations in human biology are often only uncovered in the later stage of drug
      development. In this article, the Industry Pharmacogenomics Working Group
      provides, for regulatory consideration, its perspective on the rationale for the 
      conduct of what is commonly referred to as the prospective-retrospective analysis
      (PRA) of biomarkers. Reflecting on published proposals and materials presented by
      the US FDA, a decision tree for generating robust scientific data from samples
      collected from an already conducted trial to allow PRA is presented. The primary 
      utility of the PRA is to define a process that provides robust scientific
      evidence for decision-making in situations where it is not necessary, nor
      practical or ethical to conduct a new prospective clinical study.
FAU - Patterson, Scott D
AU  - Patterson SD
AD  - Medical Sciences, Amgen Inc., 1 Amgen Center Drive MS 38-3-A, Thousand Oaks, CA
      91320, USA. spatters@amgen.com
FAU - Cohen, Nadine
AU  - Cohen N
FAU - Karnoub, Maha
AU  - Karnoub M
FAU - Truter, Sharada Louis
AU  - Truter SL
FAU - Emison, Eileen
AU  - Emison E
FAU - Khambata-Ford, Shirin
AU  - Khambata-Ford S
FAU - Spear, Brian
AU  - Spear B
FAU - Ibia, Ekopimo
AU  - Ibia E
FAU - Sproule, Rizwana
AU  - Sproule R
FAU - Barnes, Diane
AU  - Barnes D
FAU - Bhathena, Anahita
AU  - Bhathena A
FAU - Bristow, Michael R
AU  - Bristow MR
FAU - Russell, Chris
AU  - Russell C
FAU - Wang, Dai
AU  - Wang D
FAU - Warner, Amelia
AU  - Warner A
FAU - Westelinck, Agnes
AU  - Westelinck A
FAU - Brian, William
AU  - Brian W
FAU - Snapir, Amir
AU  - Snapir A
FAU - Franc, Monique A
AU  - Franc MA
FAU - Wong, Peggy
AU  - Wong P
FAU - Shaw, Peter M
AU  - Shaw PM
LA  - eng
PT  - Journal Article
PL  - England
TA  - Pharmacogenomics
JT  - Pharmacogenomics
JID - 100897350
RN  - 0 (Biomarkers, Pharmacological)
RN  - 0 (KRAS protein, human)
RN  - 0 (Proto-Oncogene Proteins)
RN  - EC 3.6.5.2 (Proto-Oncogene Proteins p21(ras))
RN  - EC 3.6.5.2 (ras Proteins)
SB  - IM
MH  - *Biomarkers, Pharmacological
MH  - Clinical Trials as Topic
MH  - Decision Making
MH  - Humans
MH  - Industry
MH  - Pharmacogenetics/*standards
MH  - Precision Medicine
MH  - Prospective Studies
MH  - Proto-Oncogene Proteins/genetics
MH  - Proto-Oncogene Proteins p21(ras)
MH  - Retrospective Studies
MH  - Treatment Outcome
MH  - United States
MH  - United States Food and Drug Administration
MH  - ras Proteins/genetics
EDAT- 2011/07/27 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/27 06:00
PHST- 2011/07/27 06:00 [entrez]
PHST- 2011/07/27 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.2217/pgs.11.52 [doi]
PST - ppublish
SO  - Pharmacogenomics. 2011 Jul;12(7):939-51. doi: 10.2217/pgs.11.52.


PMID- 21786728
OWN - NLM
STAT- MEDLINE
DCOM- 20110811
LR  - 20211203
IS  - 0256-9574 (Print)
VI  - 101
IP  - 4
DP  - 2011 Apr
TI  - Deliberating about race as a variable in biomedical research.
PG  - 248-50
AB  - Race as a variable in research ethics is investigated: to what extent is it
      morally appropriate to regard the race of research subjects as pivotal for
      research outcomes? The challenges it poses to deliberation in research ethics
      committees are considered, and it is concluded that race sometimes must be
      considered, subject to clearly stated qualifications.
FAU - van Niekerk, Anton A
AU  - van Niekerk AA
AD  - Centre for Applied Ethics, Stellenbosch University, W Cape. aavn@sun.ac.za
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - S Afr Med J
JT  - South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
JID - 0404520
SB  - IM
MH  - *Biomedical Research/ethics
MH  - Ethics, Research
MH  - Humans
MH  - *Racial Groups
EDAT- 2011/07/27 06:00
MHDA- 2011/08/13 06:00
CRDT- 2011/07/27 06:00
PHST- 2011/07/27 06:00 [entrez]
PHST- 2011/07/27 06:00 [pubmed]
PHST- 2011/08/13 06:00 [medline]
AID - 10.7196/samj.4702 [doi]
PST - ppublish
SO  - S Afr Med J. 2011 Apr;101(4):248-50. doi: 10.7196/samj.4702.


PMID- 21763978
OWN - NLM
STAT- MEDLINE
DCOM- 20111206
LR  - 20110718
IS  - 1769-664X (Electronic)
IS  - 0929-693X (Linking)
VI  - 18 Suppl 2
DP  - 2011 Jul
TI  - [Video recording of newborn resuscitation in the delivery room: technique and
      advantages].
PG  - S72-8
LID - 10.1016/S0929-693X(11)71094-6 [doi]
AB  - An extreme attentiveness is mandatory when caring about
      extremely-low-gestational-age neonates at birth because of their innate
      vulnerability. The interventions performed during resuscitation of these infants 
      may have direct influence on the immediate survival and also on long-term
      morbidity. Although stressfull, each resuscitation step is crucial and needs to
      be precise, fast and harmless. In order to determine our compliance to the
      international guidelines and to assess our neonatal performances in delivery
      room, we used a Mobotix camera to record all resuscitations of
      extremely-low-gestational-age neonates during the decisive first minutes of life.
      Neonatal medical and nursing staff agreed to be recorded. Our local ethics
      committee approved that videotaping neonatal resuscitation is an audit of
      clinical practice and thus does not require informed consent. During debriefing
      sessions, we reviewed the videotaped recordings, which allowed us to identify
      frequent deviations from the international guidelines and to re-educate and
      improve performance. The most frequent errors we recognized were errors of
      hygiene, not re-evaluating oxygen titration and airway obstruction during mask
      ventilation. We observed team behaviour and coordination during resuscitation and
      focused on quality of care. We believe that this method may be very effective as 
      a teaching tool.
CI  - Copyright (c) 2011 Elsevier Masson SAS. All rights reserved.
FAU - Layouni, I
AU  - Layouni I
FAU - Danan, C
AU  - Danan C
FAU - Durrmeyer, X
AU  - Durrmeyer X
FAU - Dassieu, G
AU  - Dassieu G
FAU - Azcona, B
AU  - Azcona B
FAU - Decobert, F
AU  - Decobert F
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Enregistrement video de situations reelles de reanimation en salle de naissance: 
      technique et avantages.
PL  - France
TA  - Arch Pediatr
JT  - Archives de pediatrie : organe officiel de la Societe francaise de pediatrie
JID - 9421356
SB  - IM
MH  - Clinical Audit
MH  - *Delivery Rooms
MH  - Guideline Adherence
MH  - Humans
MH  - Infant, Extremely Low Birth Weight
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Medical Errors
MH  - Practice Guidelines as Topic
MH  - Quality Assurance, Health Care
MH  - Resuscitation/*standards
MH  - *Video Recording
EDAT- 2011/07/27 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/19 06:00
PHST- 2011/07/19 06:00 [entrez]
PHST- 2011/07/27 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0929-693X(11)71094-6 [pii]
AID - 10.1016/S0929-693X(11)71094-6 [doi]
PST - ppublish
SO  - Arch Pediatr. 2011 Jul;18 Suppl 2:S72-8. doi: 10.1016/S0929-693X(11)71094-6.


PMID- 21786428
OWN - NLM
STAT- MEDLINE
DCOM- 20120118
LR  - 20110913
IS  - 1935-9780 (Electronic)
IS  - 1935-9772 (Linking)
VI  - 4
IP  - 5
DP  - 2011 Sep-Oct
TI  - Developing observational skills and knowledge of anatomical relationships in an
      art and anatomy workshop using plastinated specimens.
PG  - 294-301
LID - 10.1002/ase.244 [doi]
AB  - One of the strong trends in medical education today is the integration of the
      humanities into the basic medical curriculum. The anatomy program is an obvious
      choice for using the humanities to develop professionalism and ethical values.
      They can also be used to develop close observational skills. Many medical schools
      have developed formal art observation training in conjunction with nearby art
      museums to enhance the visual diagnostic skills of their medical students. We
      report here on an art and anatomy workshop that paired medical and art students
      who did drawing exercises from plastinated anatomical specimens and the animated 
      face to hone observational skills. Each member of the pair brought a different
      perspective and expertise to the work that allowed each to be a mentor to the
      other. The workshop had three sessions: the first involved drawings of
      plastinated specimens that allowed an intimate experience with authentic human
      material; the second involved drawings of the human face; and the third included 
      examination of anatomical texts of important anatomist-artists, a lecture on
      contemporary artists whose work involves anatomy, and a film demonstrating the
      facial muscles. We propose workshops such as these will help students increase
      their ability to detect details. This will assist the medical student in
      developing diagnostic skills for identifying disease and the art student in using
      the human body as subject. We further propose that these programs will help
      students develop humanistic sensitivities and provide an outlet for expression of
      the emotional aspects of dealing with disease and mortality.
CI  - Copyright (c) 2011 American Association of Anatomists.
FAU - Moore, Charleen M
AU  - Moore CM
AD  - Department of Cellular and Structural Biology, University of Texas Health Science
      Center at San Antonio, 78229-3900, USA. moorec@uthscsa.edu
FAU - Lowe, Constance
AU  - Lowe C
FAU - Lawrence, Jane
AU  - Lawrence J
FAU - Borchers, Penelope
AU  - Borchers P
LA  - eng
PT  - Journal Article
DEP - 20110722
PL  - United States
TA  - Anat Sci Educ
JT  - Anatomical sciences education
JID - 101392205
SB  - IM
MH  - Anatomy, Artistic/*education
MH  - *Art
MH  - Education, Medical, Undergraduate/methods
MH  - Face/anatomy & histology
MH  - Humans
MH  - Observation
EDAT- 2011/07/26 06:00
MHDA- 2012/01/19 06:00
CRDT- 2011/07/26 06:00
PHST- 2011/03/13 00:00 [received]
PHST- 2011/06/13 00:00 [revised]
PHST- 2011/06/20 00:00 [accepted]
PHST- 2011/07/26 06:00 [entrez]
PHST- 2011/07/26 06:00 [pubmed]
PHST- 2012/01/19 06:00 [medline]
AID - 10.1002/ase.244 [doi]
PST - ppublish
SO  - Anat Sci Educ. 2011 Sep-Oct;4(5):294-301. doi: 10.1002/ase.244. Epub 2011 Jul 22.


PMID- 21786000
OWN - NLM
STAT- MEDLINE
DCOM- 20131126
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 1
DP  - 2013 Mar
TI  - Is human enhancement also a personal matter?
PG  - 161-77
LID - 10.1007/s11948-011-9294-y [doi]
AB  - Emerging technologies are increasingly used in an attempt to "enhance the human
      body and/or mind" beyond the contemporary standards that characterize human
      beings. Yet, such standards are deeply controversial and it is not an easy task
      to determine whether the application of a given technology to an individual and
      its outcome can be defined as a human enhancement or not. Despite much debate on 
      its potential or actual ethical and social impacts, human enhancement is not
      subject to any consensual definition. This paper proposes a timely and much
      needed examination of the various definitions found in the literature. We
      classify these definitions into four main categories: the implicit approach, the 
      therapy-enhancement distinction, the improvement of general human capacities and 
      the increase of well-being. After commenting on these different approaches and
      their limitations, we propose a definition of human enhancement that focuses on
      individual perceptions. While acknowledging that a definition that mainly depends
      on personal and subjective individual perceptions raises many challenges, we
      suggest that a comprehensive approach to define human enhancement could
      constitute a useful premise to appropriately address the complexity of the
      ethical and social issues it generates.
FAU - Menuz, Vincent
AU  - Menuz V
AD  - Department of Social and Preventive Medicine, Bioethics Programs, University of
      Montreal, Montreal, Canada. vincent.menuz@umontreal.ca
FAU - Hurlimann, Thierry
AU  - Hurlimann T
FAU - Godard, Beatrice
AU  - Godard B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110723
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Biomedical Enhancement/*ethics
MH  - Humans
MH  - Perception
MH  - *Social Values
MH  - Terminology as Topic
EDAT- 2011/07/26 06:00
MHDA- 2013/12/16 06:00
CRDT- 2011/07/26 06:00
PHST- 2011/03/10 00:00 [received]
PHST- 2011/07/05 00:00 [accepted]
PHST- 2011/07/26 06:00 [entrez]
PHST- 2011/07/26 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1007/s11948-011-9294-y [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Mar;19(1):161-77. doi: 10.1007/s11948-011-9294-y. Epub 2011 
      Jul 23.


PMID- 21785999
OWN - NLM
STAT- MEDLINE
DCOM- 20120727
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 17
IP  - 4
DP  - 2011 Dec
TI  - The broad challenge of public engagement in science: commentary on:
      "Constitutional moments in governing science and technology".
PG  - 639-48
LID - 10.1007/s11948-011-9296-9 [doi]
AB  - Timely public engagement in science presents a broad challenge. It includes more 
      than research into the ethical, legal and social dimensions of science and
      state-initiated citizen's participation. Introducing a public perspective on
      science while safeguarding its public value involves a diverse set of actors:
      natural scientists and engineers, technology assessment institutes, policy
      makers, social scientists, citizens, interest organisations, artists, and last,
      but not least, politicians.
FAU - van Est, Rinie
AU  - van Est R
AD  - Technology Assessment Department, Rathenau Institute, P.O. Box 95366, 2509 CJ The
      Hague, The Netherlands. q.vanest@rathenau.nl
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20110723
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
CON - Sci Eng Ethics. 2011 Dec;17(4):621-38. PMID: 21879357
MH  - Community Participation/*history
MH  - Humans
MH  - Public Policy/*history
MH  - Science/*history
MH  - Social Sciences/*history
MH  - Social Values/*history
MH  - Technology/*history
PMC - PMC3242943
EDAT- 2011/07/26 06:00
MHDA- 2012/07/28 06:00
CRDT- 2011/07/26 06:00
PHST- 2008/10/20 00:00 [received]
PHST- 2011/05/23 00:00 [accepted]
PHST- 2011/07/26 06:00 [entrez]
PHST- 2011/07/26 06:00 [pubmed]
PHST- 2012/07/28 06:00 [medline]
AID - 10.1007/s11948-011-9296-9 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2011 Dec;17(4):639-48. doi: 10.1007/s11948-011-9296-9. Epub 2011 
      Jul 23.


PMID- 21785584
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1687-630X (Electronic)
IS  - 1687-6121 (Linking)
VI  - 2012
DP  - 2012
TI  - Low-Radiation-Dose Modified Small Bowel CT for Evaluation of Recurrent Crohn's
      Disease.
PG  - 598418
LID - 10.1155/2012/598418 [doi]
AB  - Crohn's disease affects any part of the GI tract, commonly the terminal ileum. To
      decrease radiation exposure we developed a low-radiation-dose unenhanced CT
      (modified small Bowel CT, MBCT) to evaluate the small bowel using hyperdense oral
      contrast. Technique. MBCT was investigated in patients with pathologically proven
      Crohn's disease presenting with new symptoms from recurrent inflammation or
      stricture. After ethics board approval, 98 consecutive patients were
      retrospectively evaluated. Kappa values from two independent reviewers were
      calculated for presence of obstruction, active inflammation versus chronic
      stricture, and ancillary findings. Forty-two patients underwent surgery or
      colonoscopy within 3 months. Results. Kappa was 0.84 for presence of abnormality 
      versus a normal exam and 0.89 for differentiating active inflammation from
      chronic stricture. Level of agreement for presence of skip areas, abscess
      formation, and fistula was 0.62, 0.75, and 0.78, respectively. In the subset with
      "gold standard" follow-up, there was 83% agreement. Conclusions. MBCT is a
      low-radiation technique with good to very good interobserver agreement for
      determining presence of obstruction and degree of disease activity in patients
      with Crohn's disease. Further investigation is required to refine parameters of
      disease activity compared to CT enterography and small bowel follow through.
FAU - Kielar, A Z
AU  - Kielar AZ
AD  - Department of Radiology, The Ottawa Hospital, C-1, 1053 Carling Avenue, Ottawa,
      Ottawa, ON, Canada K1Y 4E9.
FAU - Tao, H
AU  - Tao H
FAU - McKeever, C
AU  - McKeever C
FAU - El-Maraghi, R H
AU  - El-Maraghi RH
LA  - eng
PT  - Journal Article
DEP - 20110620
PL  - Egypt
TA  - Gastroenterol Res Pract
JT  - Gastroenterology research and practice
JID - 101475557
PMC - PMC3139131
EDAT- 2011/07/26 06:00
MHDA- 2011/07/26 06:01
CRDT- 2011/07/26 06:00
PHST- 2011/02/14 00:00 [received]
PHST- 2011/04/13 00:00 [revised]
PHST- 2011/04/17 00:00 [accepted]
PHST- 2011/07/26 06:00 [entrez]
PHST- 2011/07/26 06:00 [pubmed]
PHST- 2011/07/26 06:01 [medline]
AID - 10.1155/2012/598418 [doi]
PST - ppublish
SO  - Gastroenterol Res Pract. 2012;2012:598418. doi: 10.1155/2012/598418. Epub 2011
      Jun 20.


PMID- 21785556
OWN - NLM
STAT- MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1098-0997 (Electronic)
IS  - 1064-7449 (Linking)
VI  - 2011
DP  - 2011
TI  - Aspects of prophylactic vaccination against cervical cancer and other human
      papillomavirus-related cancers in developing countries.
PG  - 675858
LID - 10.1155/2011/675858 [doi]
AB  - Cervical cancer and other human papillomavirus- (HPV-) related cancers are
      preventable, but preventive measures implemented in developing countries and
      especially in low-income rural regions have not been effective. Cervical cancer
      burden derived from sexually transmitted HPV infections is the heaviest in
      developing countries, and a dramatic increase in the number of cervical cancer
      cases is predicted, if no intervention is implemented in the near future. HPV
      vaccines offer an efficient way to prevent related cancers. Recently implemented 
      school-based HPV vaccination demonstration programmes can help tackle the
      challenges linked with vaccine coverage, and access to vaccination and health
      services, but prevention strategies need to be modified according to regional
      characteristics. In urban regions WHO-recommended vaccination strategies might be
      enough to significantly reduce HPV-related disease burden, but in the rural
      regions additional vaccination strategies, vaccinating both sexes rather than
      only females when school attendance is the highest and applying a two-dose
      regime, need to be considered. From the point of view of both public health and
      ethics identification of the most effective prevention strategies is pivotal,
      especially when access to health services is limited. Considering
      cost-effectiveness versus justice further research on optional vaccination
      strategies is warranted.
FAU - Natunen, Kari
AU  - Natunen K
AD  - School of Health Sciences, University of Tampere, Tampere, Finland.
      kari.natunen@uta.fi
FAU - Lehtinen, Johannes
AU  - Lehtinen J
FAU - Namujju, Proscovia
AU  - Namujju P
FAU - Sellors, John
AU  - Sellors J
FAU - Lehtinen, Matti
AU  - Lehtinen M
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110719
PL  - Egypt
TA  - Infect Dis Obstet Gynecol
JT  - Infectious diseases in obstetrics and gynecology
JID - 9318481
RN  - 0 (Cancer Vaccines)
RN  - 0 (Papillomavirus Vaccines)
SB  - IM
MH  - Cancer Vaccines/*administration & dosage
MH  - *Developing Countries
MH  - Female
MH  - Humans
MH  - Papillomavirus Infections/*prevention & control
MH  - Papillomavirus Vaccines/*administration & dosage
MH  - Uterine Cervical Neoplasms/*prevention & control/*virology
PMC - PMC3140204
EDAT- 2011/07/26 06:00
MHDA- 2011/11/11 06:00
CRDT- 2011/07/26 06:00
PHST- 2011/02/02 00:00 [received]
PHST- 2011/05/12 00:00 [accepted]
PHST- 2011/07/26 06:00 [entrez]
PHST- 2011/07/26 06:00 [pubmed]
PHST- 2011/11/11 06:00 [medline]
AID - 10.1155/2011/675858 [doi]
PST - ppublish
SO  - Infect Dis Obstet Gynecol. 2011;2011:675858. doi: 10.1155/2011/675858. Epub 2011 
      Jul 19.


PMID- 21785486
OWN - NLM
STAT- MEDLINE
DCOM- 20111122
LR  - 20220309
IS  - 2150-1149 (Electronic)
IS  - 1533-3159 (Linking)
VI  - 14
IP  - 4
DP  - 2011 Jul-Aug
TI  - Opioid abuse in cancer pain: report of two cases and presentation of an algorithm
      of multidisciplinary care.
PG  - E361-71
AB  - BACKGROUND: The growing awareness of opioid abuse and addiction in the chronic
      pain population, along with increasing cancer survivorship, has heightened our
      awareness of this potential problem in the cancer patient. An increasing number
      of patients who abuse opioids have been identified in our clinical setting.
      OBJECTIVE: We present an algorithm of multidisciplinary care for the treatment of
      cancer patients at risk for abusing opioids. SETTING: Two illustrative patient
      examples were identified recently from our clinic. RESULTS: These 2 patient
      examples demonstrate our multidisciplinary approach to treatment. A discussion of
      safe prescribing principles adapted from the literature is presented. Also, a
      brief point of added complexity is introduced; specifically, ethical
      considerations due to the unique nature of cancer pain. LIMITATIONS: Although
      validation studies exist for the use of screening tools in patients with chronic 
      noncancer pain, there have been no instrument validation studies on patients with
      cancer pain. The educational treatment model that we refer to regarding
      facilitating safe use of opioids also has not been studied on patients with
      cancer pain. Lastly, we express caution in generalizing our guidelines to
      patients with noncancer pain. Our patient population differs in the multiple
      co-existing stressors and symptom burden associated with cancer. CONCLUSIONS: We 
      have become increasingly aware of the problem of opioid abuse in the cancer pain 
      population. With an approach to using safe prescribing principles adapted from
      chronic pain literature, and an ethically based multidisciplinary approach,
      clinicians can continue to treat pain successfully in the opioid-misusing cancer 
      patient. We outline our approach in this article.
FAU - Koyyalagunta, Dhanalakshmi
AU  - Koyyalagunta D
AD  - University of Texas, MD Anderson Cancer Center, Dept. of Anesthesiology & Pain
      Medicine, Unit 409, 1400 Holcombe Blvd, Houston TX 77030-0409, USA.
      dkoyyala@mdanderson.org
FAU - Burton, Allen W
AU  - Burton AW
FAU - Toro, Marco Perez
AU  - Toro MP
FAU - Driver, Larry
AU  - Driver L
FAU - Novy, Diane M
AU  - Novy DM
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Pain Physician
JT  - Pain physician
JID - 100954394
RN  - 0 (Analgesics, Opioid)
SB  - IM
MH  - *Algorithms
MH  - Analgesics, Opioid/therapeutic use
MH  - Female
MH  - Humans
MH  - *Interprofessional Relations
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/*complications
MH  - Opioid-Related Disorders/*diagnosis
MH  - Pain/*drug therapy/etiology
MH  - Risk Assessment/methods
MH  - Substance Abuse Detection/*methods
MH  - Surveys and Questionnaires
EDAT- 2011/07/26 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/26 06:00
PHST- 2011/07/26 06:00 [entrez]
PHST- 2011/07/26 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PST - ppublish
SO  - Pain Physician. 2011 Jul-Aug;14(4):E361-71.


PMID- 21785160
OWN - NLM
STAT- MEDLINE
DCOM- 20120322
LR  - 20181201
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 1
DP  - 2012 Jan
TI  - Fear of a female planet: how John Harris came to endorse eugenic social
      engineering.
PG  - 4-7
LID - 10.1136/jme.2011.045021 [doi]
AB  - In this paper, I respond to criticisms by John Harris, contained in a commentary 
      on my article "Harris, harmed states, and sexed bodies", which appeared in the
      Journal of Medical Ethics, volume 37, number 5. I argue that Harris's response to
      my criticisms exposes the strong eugenic tendencies in his own thought, when he
      suggests that the reproductive obligations of parents should be determined with
      reference to a claim about what would enhance 'society' or 'the species'.
FAU - Sparrow, Robert
AU  - Sparrow R
AD  - School of Philosophical, Historical, and International Studies, Monash
      University, Clayton, Victoria 3800, Australia. robert.sparrow@monash.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Comment
DEP - 20110723
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
CON - J Med Ethics. 2011 May;37(5):262-6. PMID: 21508191
CIN - J Med Ethics. 2012 Jan;38(1):8. PMID: 21947812
MH  - *Bioethical Issues
MH  - Decision Making/*ethics
MH  - Female
MH  - Genetic Diseases, Inborn/*prevention & control
MH  - Genetic Enhancement/*ethics
MH  - Humans
MH  - Male
MH  - Reproductive Behavior/*ethics
EDAT- 2011/07/26 06:00
MHDA- 2012/03/23 06:00
CRDT- 2011/07/26 06:00
PHST- 2011/07/26 06:00 [entrez]
PHST- 2011/07/26 06:00 [pubmed]
PHST- 2012/03/23 06:00 [medline]
AID - jme.2011.045021 [pii]
AID - 10.1136/jme.2011.045021 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Jan;38(1):4-7. doi: 10.1136/jme.2011.045021. Epub 2011 Jul 23.


PMID- 21784641
OWN - NLM
STAT- MEDLINE
DCOM- 20111206
LR  - 20220310
IS  - 1878-4380 (Electronic)
IS  - 0966-842X (Linking)
VI  - 19
IP  - 9
DP  - 2011 Sep
TI  - Experimental human pneumococcal carriage models for vaccine research.
PG  - 464-70
LID - 10.1016/j.tim.2011.06.003 [doi]
AB  - Pneumococcal conjugate vaccines have had unprecedented success in controlling
      vaccine-type invasive pneumococcal disease. As serotype replacement and the
      complexity of designing vaccines to multiple capsular polysaccharides ultimately 
      pose a threat to these vaccines, the development of alternative protein vaccines 
      is important. Protein vaccines offer the promise of extended serotype coverage,
      reduced cost, and improved protection against otitis media and pneumococcal
      pneumonia. As placebo-controlled trials are not currently ethically justifiable, 
      human pneumococcal challenge models using prevention of carriage as a test
      endpoint offer an attractive link between preclinical studies and clinical
      efficacy trials. Experimental human pneumococcal carriage studies offer a means
      of describing mechanisms of protection against carriage and a clinical tool to
      choose between vaccine candidates.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Ferreira, Daniela M
AU  - Ferreira DM
AD  - Respiratory Infection Group, Liverpool School of Tropical Medicine, Pembroke
      Place, Liverpool, L3 5QA, UK. df13@liverpool.ac.uk
FAU - Jambo, Kondwani C
AU  - Jambo KC
FAU - Gordon, Stephen B
AU  - Gordon SB
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110723
PL  - England
TA  - Trends Microbiol
JT  - Trends in microbiology
JID - 9310916
RN  - 0 (Pneumococcal Vaccines)
SB  - IM
MH  - Animals
MH  - Carrier State/*immunology
MH  - *Human Experimentation
MH  - Humans
MH  - Models, Biological
MH  - Pneumococcal Infections/drug therapy/immunology/*prevention & control
MH  - Pneumococcal Vaccines/administration & dosage/*immunology
MH  - Randomized Controlled Trials as Topic
MH  - Streptococcus pneumoniae/*immunology
EDAT- 2011/07/26 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/26 06:00
PHST- 2011/03/31 00:00 [received]
PHST- 2011/06/02 00:00 [revised]
PHST- 2011/06/13 00:00 [accepted]
PHST- 2011/07/26 06:00 [entrez]
PHST- 2011/07/26 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0966-842X(11)00124-7 [pii]
AID - 10.1016/j.tim.2011.06.003 [doi]
PST - ppublish
SO  - Trends Microbiol. 2011 Sep;19(9):464-70. doi: 10.1016/j.tim.2011.06.003. Epub
      2011 Jul 23.


PMID- 21783450
OWN - NLM
STAT- MEDLINE
DCOM- 20120531
LR  - 20220330
IS  - 1876-2867 (Electronic)
IS  - 1876-2859 (Linking)
VI  - 11
IP  - 5
DP  - 2011 Sep-Oct
TI  - Qualitative research methods for medical educators.
PG  - 375-86
LID - 10.1016/j.acap.2011.05.001 [doi]
AB  - This paper provides a primer for qualitative research in medical education. Our
      aim is to equip readers with a basic understanding of qualitative research and
      prepare them to judge the goodness of fit between qualitative research and their 
      own research questions. We provide an overview of the reasons for choosing a
      qualitative research approach and potential benefits of using these methods for
      systematic investigation. We discuss developing qualitative research questions,
      grounding research in a philosophical framework, and applying rigorous methods of
      data collection, sampling, and analysis. We also address methods to establish the
      trustworthiness of a qualitative study and introduce the reader to ethical
      concerns that warrant special attention when planning qualitative research. We
      conclude with a worksheet that readers may use for designing a qualitative study.
      Medical educators ask many questions that carefully designed qualitative research
      would address effectively. Careful attention to the design of qualitative studies
      will help to ensure credible answers that will illuminate many of the issues,
      challenges, and quandaries that arise while doing the work of medical education.
CI  - Copyright (c) 2011 Academic Pediatric Association. All rights reserved.
FAU - Hanson, Janice L
AU  - Hanson JL
AD  - Department of Medicine, Uniformed Services University of the Health Sciences,
      Bethesda, MD 20814, USA. jhanson@usuhs.mil
FAU - Balmer, Dorene F
AU  - Balmer DF
FAU - Giardino, Angelo P
AU  - Giardino AP
LA  - eng
PT  - Journal Article
DEP - 20110723
PL  - United States
TA  - Acad Pediatr
JT  - Academic pediatrics
JID - 101499145
SB  - IM
MH  - Data Collection
MH  - *Education, Medical
MH  - Humans
MH  - *Pediatrics
MH  - *Qualitative Research
MH  - *Research Design
EDAT- 2011/07/26 06:00
MHDA- 2012/06/01 06:00
CRDT- 2011/07/26 06:00
PHST- 2010/09/04 00:00 [received]
PHST- 2011/04/29 00:00 [revised]
PHST- 2011/05/12 00:00 [accepted]
PHST- 2011/07/26 06:00 [entrez]
PHST- 2011/07/26 06:00 [pubmed]
PHST- 2012/06/01 06:00 [medline]
AID - S1876-2859(11)00131-8 [pii]
AID - 10.1016/j.acap.2011.05.001 [doi]
PST - ppublish
SO  - Acad Pediatr. 2011 Sep-Oct;11(5):375-86. doi: 10.1016/j.acap.2011.05.001. Epub
      2011 Jul 23.


PMID- 21783397
OWN - NLM
STAT- MEDLINE
DCOM- 20120726
LR  - 20111128
IS  - 2171-8695 (Electronic)
IS  - 1130-6343 (Linking)
VI  - 35
IP  - 6
DP  - 2011 Nov-Dec
TI  - [Ethical and legal responsibility of the hospital pharmacist].
PG  - 287-8
LID - 10.1016/j.farma.2011.06.002 [doi]
FAU - Larios, David
AU  - Larios D
LA  - spa
PT  - Editorial
TT  - Responsabilidad etica y legal del farmaceutico hospitalario.
DEP - 20110723
PL  - Spain
TA  - Farm Hosp
JT  - Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad
      Espanola de Farmacia Hospitalaria
JID - 9440679
SB  - IM
MH  - *Liability, Legal
MH  - Pharmacists/*ethics/*legislation & jurisprudence
MH  - Pharmacy Service, Hospital/*ethics/*legislation & jurisprudence
EDAT- 2011/07/26 06:00
MHDA- 2012/07/27 06:00
CRDT- 2011/07/26 06:00
PHST- 2011/05/24 00:00 [received]
PHST- 2011/06/06 00:00 [accepted]
PHST- 2011/07/26 06:00 [entrez]
PHST- 2011/07/26 06:00 [pubmed]
PHST- 2012/07/27 06:00 [medline]
AID - S1130-6343(11)00108-5 [pii]
AID - 10.1016/j.farma.2011.06.002 [doi]
PST - ppublish
SO  - Farm Hosp. 2011 Nov-Dec;35(6):287-8. doi: 10.1016/j.farma.2011.06.002. Epub 2011 
      Jul 23.


PMID- 21782260
OWN - NLM
STAT- MEDLINE
DCOM- 20120810
LR  - 20110912
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 151
IP  - 3
DP  - 2011 Sep 15
TI  - Ethics, vanity and publications.
PG  - 391-2
LID - 10.1016/j.ijcard.2011.07.001 [doi]
FAU - Breijo-Marquez, Francisco R
AU  - Breijo-Marquez FR
LA  - eng
PT  - Letter
DEP - 20110722
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
SB  - IM
MH  - Humans
MH  - Periodicals as Topic/*ethics/standards
MH  - Publications/*ethics/standards
MH  - Scientific Misconduct/*ethics
EDAT- 2011/07/26 06:00
MHDA- 2012/08/11 06:00
CRDT- 2011/07/26 06:00
PHST- 2011/07/01 00:00 [received]
PHST- 2011/07/03 00:00 [accepted]
PHST- 2011/07/26 06:00 [entrez]
PHST- 2011/07/26 06:00 [pubmed]
PHST- 2012/08/11 06:00 [medline]
AID - S0167-5273(11)00687-5 [pii]
AID - 10.1016/j.ijcard.2011.07.001 [doi]
PST - ppublish
SO  - Int J Cardiol. 2011 Sep 15;151(3):391-2. doi: 10.1016/j.ijcard.2011.07.001. Epub 
      2011 Jul 22.


PMID- 21781234
OWN - NLM
STAT- MEDLINE
DCOM- 20120221
LR  - 20181201
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 11
IP  - 3
DP  - 2011 Dec
TI  - Ethics of human genetic studies in sub-saharan Africa: the case of Cameroon
      through a bibliometric analysis.
PG  - 120-7
LID - 10.1111/j.1471-8847.2011.00305.x [doi]
AB  - UNLABELLED: Many ethical concerns surrounding human genetics studies remain
      unresolved. We report here the situation in Cameroon. OBJECTIVES: To describe the
      profile of human genetic studies that used Cameroonian DNA samples, with specific
      focus on i) the research centres that were involved, ii) authorship, iii)
      population studied, iv) research topics and v) ethics disclosure, with the aim of
      raising ethical issues that emerged from these studies. METHOD: Bibliometric
      Studies; we conducted a PubMed-based systematic review of all the studies on
      human genetics that used Cameroonian DNA samples from 1989 to 2009. RESULTS AND
      DISCUSSION: Fifty articles were identified, involving predominantly research
      centres from Europe (64%) and America (32%). Only 7 (14%) Cameroonian
      institutions and 14 (28%) Cameroonian authors were associated with these
      publications. At least 52% of publications were devoted to population genetics
      (variation/migration patterns) amongst 30 Cameroonian ethnic groups. Very few
      studies concerned public health related genetic issues and only 5 (10%)
      references were found for hemoglobinopathies like sickle cell anaemia. Almost all
      DNA samples are 'banked' outside of the African continent. Capacity building,
      rights to the genetic information and benefits to the individuals, communities
      and populations who contribute to these studies are addressed. CONCLUSIONS: 1)
      Our data suggests the need for a wider debate towards building capacity and
      addressing ethical issues related to human genomic research in sub-Saharan Africa
      and specifically in Cameroon; 2) National ethical guidelines and regulations
      concerning the collection, use and storage of human DNA are urgently needed in
      Cameroon.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Wonkam, Ambroise
AU  - Wonkam A
AD  - Faculty of Health Sciences, Division of Human Genetics, University of Cape Town, 
      Anzio Road, Cape Town 7925, South Africa. ambroise.wonkam@uct.ac.za
FAU - Kenfack, Marcel Azabji
AU  - Kenfack MA
FAU - Muna, Walinjom F T
AU  - Muna WF
FAU - Ouwe-Missi-Oukem-Boyer, Odile
AU  - Ouwe-Missi-Oukem-Boyer O
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20110722
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
SB  - IM
MH  - Africa
MH  - Bibliometrics
MH  - Cameroon
MH  - Ethics, Research
MH  - Europe
MH  - Genetic Research/*ethics
MH  - *Genome, Human
MH  - Humans
MH  - United States
EDAT- 2011/07/26 06:00
MHDA- 2012/02/22 06:00
CRDT- 2011/07/26 06:00
PHST- 2011/07/26 06:00 [entrez]
PHST- 2011/07/26 06:00 [pubmed]
PHST- 2012/02/22 06:00 [medline]
AID - 10.1111/j.1471-8847.2011.00305.x [doi]
PST - ppublish
SO  - Dev World Bioeth. 2011 Dec;11(3):120-7. doi: 10.1111/j.1471-8847.2011.00305.x.
      Epub 2011 Jul 22.


PMID- 21781136
OWN - NLM
STAT- MEDLINE
DCOM- 20120829
LR  - 20131121
IS  - 1365-2885 (Electronic)
IS  - 0140-7783 (Linking)
VI  - 35
IP  - 3
DP  - 2012 Jun
TI  - Development and validation of a tissue cage model of acute inflammation in the
      cat.
PG  - 239-48
LID - 10.1111/j.1365-2885.2011.01308.x [doi]
AB  - Four cylindrical silicon tissue cages (TC, internal volume: 6.7 +/- 0.11 cm(3))
      were inserted subcutaneously in 29 young healthy cats. A mild inflammatory
      reaction was induced by intracaveal injection of 1 mL of a 2%lambda-carrageenan
      solution. TC exudate was subsequently sampled at predetermined times (up to 120
      h) to measure exudate leucocyte counts and the concentrations of protein and
      eicosanoids. TC remained in situ for 9-10 months and were well tolerated.
      Leucocyte counts peaked at 34 h (50.1 +/- 57.6 x 10(3) cells/mm(3) ) and returned
      towards baseline after 72 h. Protein concentration increased from 26.2 +/- 2.7
      g/L to a peak of 35.9 +/- 6.0 g/L at 12 h before returning to baseline at 48 h.
      Exudate prostaglandin (PG)E(2) concentration peaked at 24 h (11.7 +/- 13.7 ng/mL)
      and returned to baseline by 120 h. Repeated collection of fluid from noninjected 
      cages did not increase transudate PGE(2). Ketoprofen (2 mg/kg, subcutaneously)
      suppressed exudate PGE(2) at 24 h. The carrageenan-stimulated TC model is an
      ethical and novel means of investigating soft tissue inflammation in the cat, in 
      which exudate PGE(2) acts as surrogate marker of cyclooxygenase-2 activity. This 
      model will facilitate the investigation of in vivo pharmacokinetics and
      pharmacodynamics of anti-inflammatory drugs in this species.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Pelligand, L
AU  - Pelligand L
AD  - Department of Veterinary Basic Sciences, Royal Veterinary College, Hatfield,
      Herts, UK. lpelligand@rvc.ac.uk
FAU - House, A K
AU  - House AK
FAU - Summers, B A
AU  - Summers BA
FAU - Hatzis, A
AU  - Hatzis A
FAU - Tivers, M
AU  - Tivers M
FAU - Elliott, J
AU  - Elliott J
FAU - Lees, P
AU  - Lees P
LA  - eng
GR  - Biotechnology and Biological Sciences Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110721
PL  - England
TA  - J Vet Pharmacol Ther
JT  - Journal of veterinary pharmacology and therapeutics
JID - 7910920
RN  - 0 (Anti-Inflammatory Agents)
RN  - 9000-07-1 (Carrageenan)
RN  - K7Q1JQR04M (Dinoprostone)
RN  - Z4152N8IUI (Silicon)
SB  - IM
MH  - Acute Disease
MH  - Animals
MH  - Anti-Inflammatory Agents/pharmacology/therapeutic use
MH  - Carrageenan/pharmacology
MH  - Cat Diseases/*chemically induced/etiology/immunology
MH  - Cats
MH  - Diffusion Chambers, Culture/*veterinary
MH  - Dinoprostone/analysis
MH  - *Disease Models, Animal
MH  - Exudates and Transudates/chemistry
MH  - Inflammation/chemically induced/drug therapy/immunology/*veterinary
MH  - Injections, Subcutaneous
MH  - Leukocyte Count/veterinary
MH  - Silicon
EDAT- 2011/07/26 06:00
MHDA- 2012/08/30 06:00
CRDT- 2011/07/26 06:00
PHST- 2011/07/26 06:00 [entrez]
PHST- 2011/07/26 06:00 [pubmed]
PHST- 2012/08/30 06:00 [medline]
AID - 10.1111/j.1365-2885.2011.01308.x [doi]
PST - ppublish
SO  - J Vet Pharmacol Ther. 2012 Jun;35(3):239-48. doi:
      10.1111/j.1365-2885.2011.01308.x. Epub 2011 Jul 21.


PMID- 21780359
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20110725
IS  - 0265-539X (Print)
IS  - 0265-539X (Linking)
VI  - 28
IP  - 2
DP  - 2011 Jun
TI  - Is there a correlation between dental caries and body mass index-for-age among
      adolescents in Iran?
PG  - 174-7
AB  - AIM: Obesity in adolescents is a public health problem and is steadily increasing
      in many countries. The aim of this study was to investigate the association
      between age-and gender-specific body mass index (BMI-for-age) and dental caries
      among adolescents aged 12 -15 years in Rafsanjan, Iran. MATERIALS AND METHODS:
      Following ethical approval, 747 students aged 12-15 years were randomly selected 
      from 12 state and private secondary schools in Rafsanjan, Iran. The DMFT index
      (following World Health Organization criteria) was used to assess the subjects'
      previous and existing dental caries experience. The BMI (Body Mass Index)
      percentile was calculated using BMI-for-age criteria as underweight (< 5th
      percent), normal-weight (5th-85th percent), at risk of being overweight (> 85th
      and < 95th percent) and overweight (> or = 95th percent). RESULTS: Of 353 males
      and 394 females examined, 7.5% were underweight, 72.8% were normal-weight, 13.8% 
      were at risk of being overweight, and 5.9% were overweight. The mean DMFT was
      2.83. There was no significant difference between DMFT scores amongst the
      BMI-for-age groups (underweight = 2.91, normal-weight = 2.92, at risk of
      overweight = 2.54, overweight = 2.34, p > 0.05). However, males were more likely 
      to have caries than females (11% of males were caries-free, in comparison to
      20.6% of females; p < 0.05). CONCLUSION: Almost one in five adolescents (19.7%)
      examined were deemed to be at risk of being overweight, or were classified as
      overweight. There was no association between DMFT scores and BMI-for-age scores.
FAU - Sadeghi, M
AU  - Sadeghi M
AD  - Department of Restorative Dentistry, Dental School, Rafsanjan University of
      Medical Sciences, Rafsanjan, Iran.
FAU - Lynch, C D
AU  - Lynch CD
FAU - Arsalan, A
AU  - Arsalan A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Community Dent Health
JT  - Community dental health
JID - 8411261
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - *Body Mass Index
MH  - Body Weight
MH  - Child
MH  - Cross-Sectional Studies
MH  - DMF Index
MH  - Dental Caries/*complications
MH  - Dental Restoration, Permanent
MH  - Female
MH  - Humans
MH  - Iran
MH  - Male
MH  - Overweight/complications
MH  - Sex Factors
MH  - Thinness/complications
MH  - Tooth Loss/complications
EDAT- 2011/07/26 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/07/26 06:00
PHST- 2011/07/26 06:00 [entrez]
PHST- 2011/07/26 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
PST - ppublish
SO  - Community Dent Health. 2011 Jun;28(2):174-7.


PMID- 21780016
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20160526
IS  - 1098-8947 (Electronic)
IS  - 0743-684X (Linking)
VI  - 27
IP  - 8
DP  - 2011 Oct
TI  - Exploration of the intravascular stenting method for sub 1-mm vessels.
PG  - 461-8
LID - 10.1055/s-0031-1284241 [doi]
AB  - The intravascular stenting (IVaS) method was published by Narushima and Koshima
      in 2008. This method involves using a monofilament nylon stent to make the
      anastomosis of small vessels easier. The aim of this study was to explore the
      IVaS technique to determine its advantages, disadvantages, and usefulness for
      inexperienced microsurgeons and also for more experienced practitioners during
      difficult anastomoses. The study was approved by the Catholic University of
      Louvain Animal Experimentation Ethics Committee. The study was done on 20 Wistar 
      rats; each rat acting as his own control. Group 1 had an anastomosis done with
      the IVaS technique on the femoral artery. Group 2 had a classic end-to-end
      anastomosis without a stent. All anastomoses were performed by the same trainee
      surgeon with 4 months experience in microsurgery. The diameter of the external
      artery, distance between the double clamp forceps, stent length, number of
      sutures, stent preparation, and installation time and suture time were all
      measured. Anastomotic patency was verified using O'Brien's Patency test. The rats
      were anesthetized 1 week later to reassess the patency of the vessels. While the 
      anastomotic time was shorter in the stent group, the preparation time was longer 
      and so the total time to perform the anastomosis in both groups was the same. All
      vessels were patent at the completion of the anastomosis. At 1 week, patency
      rates were identical (83.3%) in both groups. The study shows an improvement in
      suturing time in the IVaS group. The time saved is equivalent to the time
      required for preparation and installation of the stent. At 7 days, the Patency
      test was identical for the two groups (83.3%). IVaS technique is a useful method 
      of vessels anastomosis especially for junior surgeons. The reason why the patency
      rate was not 100% at 1 week may be because of excessive manipulation of the stent
      causing thrombosis in the IVaS group and imperfections in suturing technique by a
      trainee surgeon. Different aspects of the method are open for discussion such as 
      consideration of the stent size and execution of the anastomosis. The IVaS
      technique helps in the execution of anastomosis in microsurgery and allows for
      more precise suturing. Care, however, must be taken in its execution and
      manipulation so as to avoid any lesions of the intima of the vessels.
CI  - (c) Thieme Medical Publishers.
FAU - Bossut, Catherine
AU  - Bossut C
AD  - Department of Orthopaedics, Catholic University of Louvain, Bruxelles, Belgium.
      c_bossut@hotmail.com
FAU - Barbier, Olivier
AU  - Barbier O
LA  - eng
PT  - Journal Article
DEP - 20110721
PL  - United States
TA  - J Reconstr Microsurg
JT  - Journal of reconstructive microsurgery
JID - 8502670
RN  - 0 (Nylons)
SB  - IM
MH  - Anastomosis, Surgical/instrumentation
MH  - Animals
MH  - Femoral Artery/*surgery
MH  - Microsurgery/instrumentation
MH  - Models, Animal
MH  - Nylons
MH  - Rats
MH  - Rats, Wistar
MH  - *Stents
MH  - Suture Techniques
MH  - Time Factors
MH  - Treatment Outcome
MH  - Vascular Patency
MH  - Vascular Surgical Procedures/*instrumentation
EDAT- 2011/07/23 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/07/23 06:00
PHST- 2011/07/23 06:00 [entrez]
PHST- 2011/07/23 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - 10.1055/s-0031-1284241 [doi]
PST - ppublish
SO  - J Reconstr Microsurg. 2011 Oct;27(8):461-8. doi: 10.1055/s-0031-1284241. Epub
      2011 Jul 21.


PMID- 21779971
OWN - NLM
STAT- MEDLINE
DCOM- 20111202
LR  - 20211020
IS  - 1573-3394 (Electronic)
IS  - 1065-3058 (Linking)
VI  - 19
IP  - 3
DP  - 2011 Sep
TI  - The ethics of biobanking: key issues and controversies.
PG  - 207-19
LID - 10.1007/s10728-011-0184-x [doi]
FAU - Widdows, Heather
AU  - Widdows H
FAU - Cordell, Sean
AU  - Cordell S
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Health Care Anal
JT  - Health care analysis : HCA : journal of health philosophy and policy
JID - 9432537
MH  - *Bioethical Issues
MH  - Biological Specimen Banks/*ethics
MH  - Biomedical Research/*ethics
MH  - Confidentiality/ethics
MH  - Feedback
MH  - Humans
MH  - Income
MH  - Informed Consent/ethics
MH  - Ownership/ethics
MH  - United Kingdom
EDAT- 2011/07/23 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/23 06:00
PHST- 2011/07/23 06:00 [entrez]
PHST- 2011/07/23 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/s10728-011-0184-x [doi]
PST - ppublish
SO  - Health Care Anal. 2011 Sep;19(3):207-19. doi: 10.1007/s10728-011-0184-x.


PMID- 21779669
OWN - NLM
STAT- MEDLINE
DCOM- 20120119
LR  - 20191210
IS  - 1678-2925 (Electronic)
IS  - 0004-2749 (Linking)
VI  - 74
IP  - 2
DP  - 2011 Mar-Apr
TI  - [Efficacy of fibrin tissue adhesive in the attachment of autogenous conjuntival
      graft on primary pterygium surgery].
PG  - 123-6
LID - S0004-27492011000200011 [pii]
AB  - PURPOSE: To compare the efficacy of conjunctival autograft surgery with the
      attachment to the scleral bed using fibrin tissue adhesive or mononylon 10-0
      suture after resection of primary pterygium. METHODS: A comparative, prospective 
      and randomized clinical trial was performed in 47 eyes of 47 patients with
      primary medial located pterygium. Group 1 (adhesive) was composed by 21 patients 
      that underwent conjunctival autograft closure with fibrin tissue adhesive
      (Quixil) and Group 2 (suture) was composed by 26 patients that underwent
      pterygium surgery with mononylon 10-0 (Ethicon((R))) suture (suture group) after 
      pterygium excision. All surgeries were performed by the same surgeon. Patients
      were assessed on the preoperative period and on the 1(st), 14(th) and 21(st)
      postoperative days. They were followed-up with a questionnaire of ocular
      discomfort and by the surgical time spent, ocular hyperemia, complications and
      recurrence signals, being the recurrence also evaluated at the 6th postoperative 
      month. Data were submitted to statistical analysis. A value of p<0.005 was
      considered statistically significant. RESULTS: The average surgical time was
      19.05 +/- 6.12 minutes in group 1 (glue) and 48.15 +/- 7.13 minutes in the group 
      2 (suture) (p<0.001). The ocular discomfort scale analysis showed a lower score
      in the 1(st) (p<0.005), 7(th) (p<0.001) and 21(th) (p<0.001) postoperative days
      in group 1. Ocular hyperemia was less intense in all periods of this study in
      group 1 (p<0.001). Complications were one in each group and both were managed
      with clinical treatment until the 21(th) postoperative day. There was one
      recurrence in group 1 and two in group 2 until the 6(th) postoperative month.
      CONCLUSION: In the surgical management of primary pterygium, fibrin tissue
      adhesive attached the conjunctival autograft, decreased the surgical time and
      diminished the conjunctival hyperemia and ocular discomfort with similar
      recurrences on the postoperative period, compared to fixation with mononylon 10.0
      suture, proving to be an excellent option for conjunctival autograft attachment
      in primary pterygium surgery.
FAU - Rubin, Michel Risnic
AU  - Rubin MR
AD  - Departamento de Oftalmologia, Irmandade da Santa Casa de Misericordia de Sao
      Paulo, SP, Brasil. rubinmichel@hotmail.com
FAU - Dantas, Paulo Elias C
AU  - Dantas PE
FAU - Nishiwaki-Dantas, M Cristina
AU  - Nishiwaki-Dantas MC
FAU - Felberg, Sergio
AU  - Felberg S
LA  - por
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Validation Study
TT  - Eficacia do adesivo tecidual de fibrina na fixacao de enxerto conjuntival
      autogeno em cirurgias de pterigio primario.
PL  - Brazil
TA  - Arq Bras Oftalmol
JT  - Arquivos brasileiros de oftalmologia
JID - 0400645
RN  - 0 (Fibrin Tissue Adhesive)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Conjunctiva/*transplantation
MH  - Fibrin Tissue Adhesive/*therapeutic use
MH  - Humans
MH  - Hyperemia
MH  - Middle Aged
MH  - Postoperative Complications
MH  - Postoperative Period
MH  - Prospective Studies
MH  - Pterygium/*surgery
MH  - Statistics, Nonparametric
MH  - *Suture Techniques
MH  - Time Factors
MH  - Transplantation, Autologous/methods
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2011/07/23 06:00
MHDA- 2012/01/20 06:00
CRDT- 2011/07/23 06:00
PHST- 2009/10/27 00:00 [received]
PHST- 2011/05/09 00:00 [accepted]
PHST- 2011/07/23 06:00 [entrez]
PHST- 2011/07/23 06:00 [pubmed]
PHST- 2012/01/20 06:00 [medline]
AID - S0004-27492011000200011 [pii]
AID - 10.1590/s0004-27492011000200011 [doi]
PST - ppublish
SO  - Arq Bras Oftalmol. 2011 Mar-Apr;74(2):123-6. doi:
      10.1590/s0004-27492011000200011.


PMID- 21779539
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130109
LR  - 20211020
IS  - 2158-8341 (Electronic)
IS  - 2158-8333 (Linking)
VI  - 8
IP  - 6
DP  - 2011 Jun
TI  - Individuals with threatening or violent criminal behavior: civil commitment or
      release after incarceration?
PG  - 29-34
AB  - Patients who have diagnoses of a major mental illness and an antisocial
      personality disorder present administrative, clinical, legal, and ethical
      challenges. Based on an actual case, the authors discuss how clinicians could
      fulfill the obligation to the patient, mental health system, judicial system, and
      the community under these circumstances. We explore how clinical presentation of 
      symptomatology and criminal behavior contribute to challenges in determining
      psychiatric care.
FAU - Mariano, Maria Theresa
AU  - Mariano MT
AD  - State University of New York, Buffalo, New York, USA.
FAU - Grace, Jeffery
AU  - Grace J
FAU - Trigoboff, Eileen
AU  - Trigoboff E
FAU - Distefano, Diane J
AU  - Distefano DJ
FAU - Olympia, Josie L
AU  - Olympia JL
FAU - Watson, Thomas
AU  - Watson T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Innov Clin Neurosci
JT  - Innovations in clinical neuroscience
JID - 101549695
PMC - PMC3140895
OTO - NOTNLM
OT  - Major mental illness
OT  - antisocial personality disorder
OT  - criminal behavior
OT  - psychiatric care
EDAT- 2011/07/23 06:00
MHDA- 2011/07/23 06:01
CRDT- 2011/07/23 06:00
PHST- 2011/07/23 06:00 [entrez]
PHST- 2011/07/23 06:00 [pubmed]
PHST- 2011/07/23 06:01 [medline]
PST - ppublish
SO  - Innov Clin Neurosci. 2011 Jun;8(6):29-34.


PMID- 21779325
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20211020
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 6
IP  - 7
DP  - 2011
TI  - Problems with using the normal distribution--and ways to improve quality and
      efficiency of data analysis.
PG  - e21403
LID - 10.1371/journal.pone.0021403 [doi]
AB  - BACKGROUND: The gaussian or normal distribution is the most established model to 
      characterize quantitative variation of original data. Accordingly, data are
      summarized using the arithmetic mean and the standard deviation, by mean +/- SD, 
      or with the standard error of the mean, mean +/- SEM. This, together with
      corresponding bars in graphical displays has become the standard to characterize 
      variation. METHODOLOGY/PRINCIPAL FINDINGS: Here we question the adequacy of this 
      characterization, and of the model. The published literature provides numerous
      examples for which such descriptions appear inappropriate because, based on the
      "95% range check", their distributions are obviously skewed. In these cases, the 
      symmetric characterization is a poor description and may trigger wrong
      conclusions. To solve the problem, it is enlightening to regard causes of
      variation. Multiplicative causes are by far more important than additive ones, in
      general, and benefit from a multiplicative (or log-) normal approach.
      Fortunately, quite similar to the normal, the log-normal distribution can now be 
      handled easily and characterized at the level of the original data with the help 
      of both, a new sign, x/, times-divide, and notation. Analogous to mean +/- SD, it
      connects the multiplicative (or geometric) mean mean * and the multiplicative
      standard deviation s* in the form mean * x/s*, that is advantageous and
      recommended. CONCLUSIONS/SIGNIFICANCE: The corresponding shift from the symmetric
      to the asymmetric view will substantially increase both, recognition of data
      distributions, and interpretation quality. It will allow for savings in sample
      size that can be considerable. Moreover, this is in line with ethical
      responsibility. Adequate models will improve concepts and theories, and provide
      deeper insight into science and life.
FAU - Limpert, Eckhard
AU  - Limpert E
AD  - ELI-o-Research, Life Sciences, Zurich, Switzerland.
FAU - Stahel, Werner A
AU  - Stahel WA
LA  - eng
PT  - Journal Article
DEP - 20110714
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - *Normal Distribution
MH  - Statistics as Topic/*methods
PMC - PMC3136454
EDAT- 2011/07/23 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/07/23 06:00
PHST- 2010/10/29 00:00 [received]
PHST- 2011/06/01 00:00 [accepted]
PHST- 2011/07/23 06:00 [entrez]
PHST- 2011/07/23 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - 10.1371/journal.pone.0021403 [doi]
AID - 10-PONE-RA-16396 [pii]
PST - ppublish
SO  - PLoS One. 2011;6(7):e21403. doi: 10.1371/journal.pone.0021403. Epub 2011 Jul 14.


PMID- 21778954
OWN - NLM
STAT- MEDLINE
DCOM- 20111006
LR  - 20210908
IS  - 1555-7960 (Print)
IS  - 1527-3172 (Linking)
VI  - 13
IP  - 3
DP  - 2011 Jul
TI  - Global pharmaceutical development and access: critical issues of ethics and
      equity.
PG  - 16-22
LID - 10.37757/MR2011V13.N3.5 [doi]
AB  - The article presents global data on access to pharmaceuticals and discusses
      underlying barriers. Two are highly visible: pricing policies and intellectual
      property rights; two are less recognized: the regulatory environment and
      scientific and technological capacities. Two ongoing transitions influence and
      even distort the problem of universal access to medications: the epidemiologic
      transition to an increasing burden of chronic non-communicable diseases; and the 
      growing role of biotechnology products (especially immunobiologicals) in the
      pharmacopeia. Examples from Cuba and Brazil are used to explore what can and
      should be done to address commercial, regulatory, and technological aspects of
      assuring universal access to medications.
FAU - Lage, Agustin
AU  - Lage A
AD  - Molecular Immunology Center, Havana, Cuba. lage@cim.sld.cu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - MEDICC Rev
JT  - MEDICC review
JID - 100964771
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Cuba
MH  - Drug Costs/ethics/legislation & jurisprudence
MH  - Drug Discovery/economics/*ethics/legislation & jurisprudence
MH  - Drug Industry/ethics/legislation & jurisprudence
MH  - *Global Health
MH  - Health Services Accessibility/economics/*ethics/legislation & jurisprudence
MH  - *Human Rights
MH  - Humans
MH  - Patents as Topic/ethics/legislation & jurisprudence
MH  - Pharmaceutical Preparations/economics/*supply & distribution
EDAT- 2011/07/23 06:00
MHDA- 2011/10/07 06:00
CRDT- 2011/07/23 06:00
PHST- 2011/07/23 06:00 [entrez]
PHST- 2011/07/23 06:00 [pubmed]
PHST- 2011/10/07 06:00 [medline]
AID - 10.37757/MR2011V13.N3.5 [doi]
PST - ppublish
SO  - MEDICC Rev. 2011 Jul;13(3):16-22. doi: 10.37757/MR2011V13.N3.5.


PMID- 21778882
OWN - NLM
STAT- MEDLINE
DCOM- 20111212
LR  - 20110809
IS  - 1473-6578 (Electronic)
IS  - 0951-7367 (Linking)
VI  - 24
IP  - 5
DP  - 2011 Sep
TI  - Relationships, sexuality and decision-making capacity in people with an
      intellectual disability.
PG  - 398-402
LID - 10.1097/YCO.0b013e328349bbcb [doi]
AB  - PURPOSE OF REVIEW: The current review attempts to summarize the current status of
      our knowledge and clinical practice in the complex and challenging area of
      relationships and sexuality for people with an intellectual disability. RECENT
      FINDINGS: Although there has been an ideological shift within services for people
      with an intellectual disability towards person-centredness and inclusivity, this 
      change has not manifested in an obvious way at the practice level in the area of 
      relationships and sexual expression. Recent surveys of caregivers and service
      providers do show a greater awareness of the fact that sexuality is a central
      part of personal identity, yet generally restrictive or prohibitive attitudes
      prevail at both individual and organizational levels. These attitudes appear to
      reflect a fear of possible legal sanction as well as ethical and moral conflicts.
      The views and experiences of people with an intellectual disability generally
      confirm this impression that, whereas some small changes have taken place, the
      prevailing experience is of restriction. Whereas there is now an abundance of
      sexuality and relationship educational programmes available, they require more
      rigorous and systematic evaluation both in terms of their effectiveness for
      enhancing knowledge and, more importantly, for examining the impact of that
      education on behaviour and capacity to make sexuality-related decisions, which we
      know to be a fluid ability. SUMMARY: There is a need for greater education of
      caregivers and a need for discussion of the complex issues regarding
      relationships and sexuality at a societal and policy level. The development of
      self-advocacy in disability services provides a vehicle to operationalize the
      changing service ideologies in a way that provides greater opportunities for
      enriching relationship experiences whilst also preventing undue risk of harm.
      However, successful self-advocacy requires organizational support, and this
      remains the greatest challenge for service providers.
FAU - McGuire, Brian E
AU  - McGuire BE
AD  - Clinical Psychology Programme, School of Psychology, National University of
      Ireland, Galway, Ireland. Brian.mcguire@nuigalway.ie
FAU - Bayley, Austin A
AU  - Bayley AA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Psychiatry
JT  - Current opinion in psychiatry
JID - 8809880
SB  - IM
MH  - Caregivers
MH  - Communication
MH  - *Decision Making
MH  - Humans
MH  - Intellectual Disability/*psychology
MH  - *Interpersonal Relations
MH  - Sexual Behavior/*psychology
EDAT- 2011/07/23 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/07/23 06:00
PHST- 2011/07/23 06:00 [entrez]
PHST- 2011/07/23 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 10.1097/YCO.0b013e328349bbcb [doi]
PST - ppublish
SO  - Curr Opin Psychiatry. 2011 Sep;24(5):398-402. doi: 10.1097/YCO.0b013e328349bbcb.


PMID- 21778535
OWN - NLM
STAT- MEDLINE
DCOM- 20111118
LR  - 20110722
IS  - 1512-0112 (Print)
IS  - 1512-0112 (Linking)
IP  - 195
DP  - 2011 Jun
TI  - Philosophocal and legislation aspects of surrogacy.
PG  - 18-25
AB  - Among current bioethical issues one of the most dilemmatic is an issue of
      surrogacy. It causes great moral, ethical and legal debate. The article aims to
      show philosophical and legislation aspects of surrogacy. The meaning of
      "motherhood", "kinship", "liberty" in connection with surrogacy is analyzed. The 
      article provides an overview of Georgian Orthodox Church on surrogate motherhood.
FAU - Zakariadze, A
AU  - Zakariadze A
AD  - Iv. Javakhishvili Tbilisi State University, Georgia.
LA  - eng
PT  - Journal Article
PL  - Georgia (Republic)
TA  - Georgian Med News
JT  - Georgian medical news
JID - 101218222
SB  - IM
MH  - Child
MH  - Christianity
MH  - Family
MH  - Female
MH  - Humans
MH  - *Life
MH  - Morals
MH  - *Philosophy
MH  - Pregnancy
MH  - *Religion and Medicine
MH  - Reproductive Techniques, Assisted/ethics/*legislation & jurisprudence
MH  - Surrogate Mothers/*legislation & jurisprudence
EDAT- 2011/07/23 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/23 06:00
PHST- 2011/07/23 06:00 [entrez]
PHST- 2011/07/23 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PST - ppublish
SO  - Georgian Med News. 2011 Jun;(195):18-25.


PMID- 21778534
OWN - NLM
STAT- MEDLINE
DCOM- 20111118
LR  - 20110722
IS  - 1512-0112 (Print)
IS  - 1512-0112 (Linking)
IP  - 195
DP  - 2011 Jun
TI  - Manipulations with human life and surrogate motherhood: ethical aspects and moral
      guidelines.
PG  - 15-8
AB  - Surrogate motherhood necessarily leads to the question of who is really the
      mother and what is motherhood. In the judgment of the author, it is necessary to 
      develop a new culture that will bring back to every person the sense of limit and
      will help humanity develop a more accurate understanding of the duality of
      scientific and technological progress. Communication between a mother and her
      unborn child is clearly very close from the biological point of view, but at the 
      same time there exists a mental and spiritual connection. The motherly desire
      creates the link between a mother and her future child, while the relationship
      with the child is established at the moment of conception. There is a good
      alternative to the surrogate motherhood, which most appropriately corresponds to 
      a married couple or family, namely, adoption, which is one of the forms of the
      valuable service of life. The moral duty of everyone is to protect human race
      from radical attacks and various forms of manipulation and pass it over intact
      and preserved for future generations to come.
FAU - Boyko, Fr Ihor
AU  - Boyko FI
AD  - Faculty of Philosophy and Theology, Ukrainian Catholic University, Ukraine.
LA  - eng
PT  - Journal Article
PL  - Georgia (Republic)
TA  - Georgian Med News
JT  - Georgian medical news
JID - 101218222
SB  - IM
MH  - Adoption
MH  - Child
MH  - Christianity
MH  - Family
MH  - Female
MH  - Humans
MH  - *Life
MH  - Morals
MH  - Pregnancy
MH  - *Religion and Medicine
MH  - Reproductive Techniques, Assisted/*ethics/psychology
MH  - *Surrogate Mothers
EDAT- 2011/07/23 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/23 06:00
PHST- 2011/07/23 06:00 [entrez]
PHST- 2011/07/23 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PST - ppublish
SO  - Georgian Med News. 2011 Jun;(195):15-8.


PMID- 21778533
OWN - NLM
STAT- MEDLINE
DCOM- 20111118
LR  - 20110722
IS  - 1512-0112 (Print)
IS  - 1512-0112 (Linking)
IP  - 195
DP  - 2011 Jun
TI  - Gestational surrogacy: could be a way to be a way to reproduction? Pros and cons.
PG  - 11-4
AB  - The aim of this article was to address pros and cons of gestational surrogacy,
      the social and psychological issues involved in surrogate motherhood triads. Pros
      and cons of surrogacy, the possible insurgence of a hematologic disease in the
      fetus, hemolytic disease of the newborn, naturally acquired microchimerism in
      surrogacy cases, ethical, medical, psychologic, legal and religious issues of a
      problem are discussed.
FAU - Clementina, Peris
AU  - Clementina P
LA  - eng
PT  - Journal Article
PL  - Georgia (Republic)
TA  - Georgian Med News
JT  - Georgian medical news
JID - 101218222
SB  - IM
MH  - Female
MH  - Humans
MH  - Pregnancy
MH  - Reproductive Techniques, Assisted/*ethics
MH  - *Surrogate Mothers
EDAT- 2011/07/23 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/23 06:00
PHST- 2011/07/23 06:00 [entrez]
PHST- 2011/07/23 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PST - ppublish
SO  - Georgian Med News. 2011 Jun;(195):11-4.


PMID- 21778010
OWN - NLM
STAT- MEDLINE
DCOM- 20120423
LR  - 20220311
IS  - 1531-5053 (Electronic)
IS  - 0278-2391 (Linking)
VI  - 70
IP  - 3
DP  - 2012 Mar
TI  - Outcomes of patients with maxillofacial osteosarcoma: a review of 15 cases.
PG  - 734-9
LID - 10.1016/j.joms.2011.03.020 [doi]
AB  - PURPOSE: To assess clinical behavior, response to treatment, and factors
      affecting survival in maxillofacial osteosarcoma treated at a tertiary referral
      center. PATIENTS AND METHODS: Ethics-approved retrospective review of clinical
      and pathological records was undertaken for 15 patients managed by the Royal
      Melbourne Hospital Head and Neck Oncology Tumor Stream. RESULTS: Treatment was a 
      combination of surgery and chemotherapy. Chemotherapy was given as adjuvant,
      neoadjuvant, or in combination. The overall 2-, 5-, and 15-year disease-free
      survival rates in this study were 92%, 74%, and 74%, respectively. Using
      Kaplan-Meier analysis with log rank tests, increasing T stage (P = .01) and
      positive margins (P = .003) were found to affect survival significantly.
      Neoadjuvant chemotherapy was not significantly associated with tumor necrosis or 
      improved survival. CONCLUSIONS: Tumor size and adequacy of local control were
      found to be the most important predictors of outcome.
CI  - Copyright A(c) 2012 American Association of Oral and Maxillofacial Surgeons.
      Published by Elsevier Inc. All rights reserved.
FAU - DeAngelis, Adrian F
AU  - DeAngelis AF
AD  - Head, Neck Oncology Tumour Stream, Department of Surgery, Royal Melbourne
      Hospital, Parkville, Victoria, Australia.
FAU - Spinou, Catherine
AU  - Spinou C
FAU - Tsui, Alpha
AU  - Tsui A
FAU - Iseli, Tim
AU  - Iseli T
FAU - Desai, Jayesh
AU  - Desai J
FAU - Wiesenfeld, David
AU  - Wiesenfeld D
FAU - Chandu, Arun
AU  - Chandu A
LA  - eng
PT  - Journal Article
DEP - 20110720
PL  - United States
TA  - J Oral Maxillofac Surg
JT  - Journal of oral and maxillofacial surgery : official journal of the American
      Association of Oral and Maxillofacial Surgeons
JID - 8206428
SB  - IM
MH  - Adult
MH  - Aged
MH  - Disease-Free Survival
MH  - Female
MH  - Head and Neck Neoplasms/drug therapy/mortality/*surgery
MH  - Humans
MH  - Male
MH  - Mandibular Neoplasms/drug therapy/mortality/*surgery
MH  - Maxillary Neoplasms/drug therapy/mortality/*surgery
MH  - Middle Aged
MH  - Osteosarcoma/drug therapy/mortality/*surgery
MH  - Outcome Assessment, Health Care
MH  - Proportional Hazards Models
MH  - Retrospective Studies
MH  - Young Adult
EDAT- 2011/07/23 06:00
MHDA- 2012/04/24 06:00
CRDT- 2011/07/23 06:00
PHST- 2011/02/06 00:00 [received]
PHST- 2011/03/16 00:00 [revised]
PHST- 2011/03/17 00:00 [accepted]
PHST- 2011/07/23 06:00 [entrez]
PHST- 2011/07/23 06:00 [pubmed]
PHST- 2012/04/24 06:00 [medline]
AID - S0278-2391(11)00511-8 [pii]
AID - 10.1016/j.joms.2011.03.020 [doi]
PST - ppublish
SO  - J Oral Maxillofac Surg. 2012 Mar;70(3):734-9. doi: 10.1016/j.joms.2011.03.020.
      Epub 2011 Jul 20.


PMID- 21777835
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20181201
IS  - 1553-4669 (Electronic)
IS  - 1553-4650 (Linking)
VI  - 18
IP  - 4
DP  - 2011 Jul-Aug
TI  - Efficacy of a polyethylene oxide-sodium carboxymethylcellulose gel in prevention 
      of intrauterine adhesions after hysteroscopic surgery.
PG  - 462-9
LID - 10.1016/j.jmig.2011.04.007 [doi]
AB  - STUDY OBJECTIVES: To assess the efficacy of a polyethylene oxide-sodium
      carboxymethylcellulose gel (Intercoat; Gynecare, division of Ethicon, Inc.,
      Somerville, NJ) in preventing the development of de novo intrauterine adhesions
      (IUAs) after hysteroscopic surgery and to rate the patency of the internal
      uterine ostium at 1-month follow-up diagnostic hysteroscopy. DESIGN: Randomized
      controlled study (Canadian Task Force classification I). SETTING: University
      hospital. PATIENTS: One hundred ten patients diagnosed during office hysteroscopy
      as having single or multiple lesions suitable for surgical treatment or resistant
      dysfunctional uterine bleeding requiring endometrial ablation. INTERVENTIONS:
      Patients were randomized to 2 groups. Group 1 underwent hysteroscopic surgery
      plus intrauterine application of Intercoat gel, and group 2 underwent
      hysteroscopic surgery only (control group). Follow-up office hysteroscopy was
      performed at 1 month after surgery to assess the rate and severity of IUA
      formation and to rate the patency of the internal uterine ostium after the
      surgical intervention. MEASUREMENTS AND MAIN RESULTS: Compared with the group 2, 
      group 1 demonstrated a significant reduction in the incidence (6% vs 22%; p <.05)
      of de-novo IUAs. Application of the gel seemed to reduce the severity of IUAs,
      with fewer moderate and severe IUAs at follow-up in group 1 in comparison with
      group 2 (33% vs 92%). Furthermore, group 1 demonstrated significant improvement
      in the degree of patency of the internal uterine ostium (41.9% of cases) in
      comparison with diagnostic office hysteroscopy performed at enrollment (p <.05). 
      In contrast, in group 2, worsening of patency of the internal uterine ostium was 
      recorded in 18.2% of cases (p <.05). CONCLUSIONS: Intercoat gel seems to prevent 
      de novo formation of IUAs and to improve the patency of the internal uterine
      ostium at follow-up hysteroscopy. However, larger studies are needed to confirm
      these findings.
CI  - Copyright (c) 2011 AAGL. Published by Elsevier Inc. All rights reserved.
FAU - Di Spiezio Sardo, Attilio
AU  - Di Spiezio Sardo A
AD  - Department of Gynaecology and Obstetrics, and Pathophysiology of Human
      Reproduction, University of Naples Federico II, Naples, Italy.
FAU - Spinelli, Marialuigia
AU  - Spinelli M
FAU - Bramante, Silvia
AU  - Bramante S
FAU - Scognamiglio, Marianna
AU  - Scognamiglio M
FAU - Greco, Elena
AU  - Greco E
FAU - Guida, Maurizio
AU  - Guida M
FAU - Cela, Vito
AU  - Cela V
FAU - Nappi, Carmine
AU  - Nappi C
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - J Minim Invasive Gynecol
JT  - Journal of minimally invasive gynecology
JID - 101235322
RN  - 0 (Gels)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - K679OBS311 (Carboxymethylcellulose Sodium)
SB  - IM
MH  - Adult
MH  - Carboxymethylcellulose Sodium/*therapeutic use
MH  - Female
MH  - Gels
MH  - Humans
MH  - Hysteroscopy/*adverse effects
MH  - Polyethylene Glycols/*therapeutic use
MH  - Prospective Studies
MH  - Single-Blind Method
MH  - Tissue Adhesions/etiology/prevention & control
MH  - Uterine Diseases/etiology/*prevention & control
EDAT- 2011/07/23 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/23 06:00
PHST- 2011/02/05 00:00 [received]
PHST- 2011/04/20 00:00 [revised]
PHST- 2011/04/22 00:00 [accepted]
PHST- 2011/07/23 06:00 [entrez]
PHST- 2011/07/23 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S1553-4650(11)00233-0 [pii]
AID - 10.1016/j.jmig.2011.04.007 [doi]
PST - ppublish
SO  - J Minim Invasive Gynecol. 2011 Jul-Aug;18(4):462-9. doi:
      10.1016/j.jmig.2011.04.007.


PMID- 21777435
OWN - NLM
STAT- MEDLINE
DCOM- 20111107
LR  - 20220316
IS  - 1741-7015 (Electronic)
IS  - 1741-7015 (Linking)
VI  - 9
DP  - 2011 Jul 21
TI  - Can user testing of a clinical trial patient information sheet make it
      fit-for-purpose?--a randomized controlled trial.
PG  - 89
LID - 10.1186/1741-7015-9-89 [doi]
AB  - BACKGROUND: The participant information sheet (PIS) provided to potential trial
      participants is a critical part of the process of valid consent. However, there
      is long-standing concern that these lengthy and complex documents are not
      fit-for-purpose. This has been supported recently through the application of a
      performance-based approach to testing and improving readability called user
      testing. This method is now widely used to improve patient medicine
      leaflets--determining whether people can find and understand key facts. This
      study applied for the first time a controlled design to determine whether a PIS
      developed through user testing had improved readability over the original, using 
      a sheet from a UK trial in acute myeloid leukemia (AML16). METHODS: In the first 
      phase the performance of the original PIS was tested on people in the target
      group for the trial. There were three rounds of testing including 50 people in
      total--with the information revised according to its performance after each of
      the first 2 rounds. In the second phase, the revised PIS was compared with the
      original in a parallel groups randomised controlled trial (RCT) A total of 123
      participants were recruited and randomly allocated to read one version of the PIS
      to find and show understanding of 21 key facts. RESULTS: The first, developmental
      phase produced a revised PIS significantly altered in its wording and layout. In 
      the second, trial phase 66% of participants who read the revised PIS were able to
      show understanding of all aspects of the trial, compared with 15% of those
      reading the original version (Odds Ratio 11.2; Chi-square = 31.5 p < .001). When 
      asked to state a preference, 87.1% participants chose the revised PIS (Sign test 
      p < .001). CONCLUSIONS: The original PIS for the AML16 trial may not have enabled
      valid consent. Combining performance-based user testing with expertise in writing
      for patients and information design led to a significantly improved and preferred
      information sheet. User testing is an efficient method for indicating strengths
      and weaknesses in trial information, and Research Ethics Committees and
      Institutional Review Boards should consider requesting such testing, to ensure
      that PIS are fit-for-purpose.
FAU - Knapp, Peter
AU  - Knapp P
AD  - Department of Health Sciences, University of York, UK. peter.knapp@york.ac.uk
FAU - Raynor, David K
AU  - Raynor DK
FAU - Silcock, Jonathan
AU  - Silcock J
FAU - Parkinson, Brian
AU  - Parkinson B
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110721
PL  - England
TA  - BMC Med
JT  - BMC medicine
JID - 101190723
SB  - IM
MH  - Aged
MH  - *Clinical Trials as Topic
MH  - *Comprehension
MH  - Consent Forms/*standards
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - United Kingdom
PMC - PMC3152894
EDAT- 2011/07/23 06:00
MHDA- 2011/11/08 06:00
CRDT- 2011/07/23 06:00
PHST- 2011/03/22 00:00 [received]
PHST- 2011/07/21 00:00 [accepted]
PHST- 2011/07/23 06:00 [entrez]
PHST- 2011/07/23 06:00 [pubmed]
PHST- 2011/11/08 06:00 [medline]
AID - 1741-7015-9-89 [pii]
AID - 10.1186/1741-7015-9-89 [doi]
PST - epublish
SO  - BMC Med. 2011 Jul 21;9:89. doi: 10.1186/1741-7015-9-89.


PMID- 21777395
OWN - NLM
STAT- MEDLINE
DCOM- 20111128
LR  - 20110722
IS  - 1747-0803 (Electronic)
IS  - 1747-079X (Linking)
VI  - 6
IP  - 4
DP  - 2011 Jul-Aug
TI  - Ethics in pediatric cardiology marketing.
PG  - 285
LID - 10.1111/j.1747-0803.2011.00549.x [doi]
FAU - Moodie, Douglas
AU  - Moodie D
LA  - eng
PT  - Editorial
PL  - United States
TA  - Congenit Heart Dis
JT  - Congenital heart disease
JID - 101256510
SB  - IM
MH  - Cardiology/*ethics
MH  - *Codes of Ethics
MH  - Humans
MH  - Marketing of Health Services/*ethics
MH  - Pediatrics/*ethics
MH  - Quality of Health Care/ethics
MH  - United States
EDAT- 2011/07/23 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/23 06:00
PHST- 2011/07/23 06:00 [entrez]
PHST- 2011/07/23 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1111/j.1747-0803.2011.00549.x [doi]
PST - ppublish
SO  - Congenit Heart Dis. 2011 Jul-Aug;6(4):285. doi: 10.1111/j.1747-0803.2011.00549.x.


PMID- 21777037
OWN - NLM
STAT- MEDLINE
DCOM- 20110906
LR  - 20190518
IS  - 0261-1929 (Print)
IS  - 0261-1929 (Linking)
VI  - 39
IP  - 3
DP  - 2011 Jul
TI  - Is a compromise possible in Russia between animal advocates and researchers who
      use animals in harmful experiments?
PG  - 227-31
AB  - The current situation relating to the use of laboratory animals in Russia, which 
      is primarily characterised by the complete absence of legislation for their
      protection, is examined and discussed. This lack of regulation causes
      well-founded protests by animal protection organisations and a number of
      reputable politicians. It also has a negative influence on the quality of medical
      and biological research results that are obtained through the use of experimental
      animals in Russia. The opinion is expressed that the Russian scientific community
      should be able to build upon the experience of other countries - in particular,
      members of the European Union, where there is an effective system of self-control
      over the ethical and legislative regulation of animal-based research. It is
      suggested that, in Russia, the basic animal protection principles of the Three Rs
      should be introduced, when the decision on whether to finance scientific projects
      involving the use of animals is being made.
CI  - 2011 FRAME.
FAU - Loukianov, Anatoly S
AU  - Loukianov AS
AD  - Lomonosov Moscow State University, Faculty of Biology, Moscow, Russia.
      asloukianov@mail.ru
LA  - eng
PT  - Journal Article
PL  - England
TA  - Altern Lab Anim
JT  - Alternatives to laboratory animals : ATLA
JID - 8110074
SB  - IM
MH  - Animal Experimentation/*ethics/legislation & jurisprudence
MH  - Animal Rights/*legislation & jurisprudence
MH  - Animals
MH  - European Union
MH  - Public Opinion
MH  - Research Personnel/*ethics
MH  - Russia
MH  - Social Control, Formal
EDAT- 2011/07/23 06:00
MHDA- 2011/09/07 06:00
CRDT- 2011/07/23 06:00
PHST- 2011/07/23 06:00 [entrez]
PHST- 2011/07/23 06:00 [pubmed]
PHST- 2011/09/07 06:00 [medline]
AID - 10.1177/026119291103900308 [doi]
PST - ppublish
SO  - Altern Lab Anim. 2011 Jul;39(3):227-31. doi: 10.1177/026119291103900308.


PMID- 21776284
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1687-9678 (Electronic)
VI  - 2011
DP  - 2011
TI  - Technical challenges in the derivation of human pluripotent cells.
PG  - 907961
LID - 10.4061/2011/907961 [doi]
AB  - It has long been discovered that human pluripotent cells could be isolated from
      the blastocyst state of embryos and called human embryonic stem cells (ESCs).
      These cells can be adapted and propagated indefinitely in culture in an
      undifferentiated manner as well as differentiated into cell representing the
      three major germ layers: endoderm, mesoderm, and ectoderm. However, the
      derivation of human pluripotent cells from donated embryos is limited and
      restricted by ethical concerns. Therefore, various approaches have been explored 
      and proved their success. Human pluripotent cells can also be derived
      experimentally by the nuclear reprogramming of somatic cells. These techniques
      include somatic cell nuclear transfer (SCNT), cell fusion and overexpression of
      pluripotent genes. In this paper, we discuss the technical challenges of these
      approaches for nuclear reprogramming, involving their advantages and limitations.
      We will also highlight the possible applications of these techniques in the study
      of stem cell biology.
FAU - Noisa, Parinya
AU  - Noisa P
AD  - Embryo Technology and Stem Cell Research Center, School of Biotechnology,
      Institute of Agricultural Technology, Suranaree University of Technology, 111
      University Avenue, Nakhon Ratchasima 30000, Thailand.
FAU - Parnpai, Rangsun
AU  - Parnpai R
LA  - eng
PT  - Journal Article
DEP - 20110619
PL  - United States
TA  - Stem Cells Int
JT  - Stem cells international
JID - 101535822
PMC - PMC3138062
EDAT- 2011/07/22 06:00
MHDA- 2011/07/22 06:01
CRDT- 2011/07/22 06:00
PHST- 2011/03/15 00:00 [received]
PHST- 2011/04/25 00:00 [accepted]
PHST- 2011/07/22 06:00 [entrez]
PHST- 2011/07/22 06:00 [pubmed]
PHST- 2011/07/22 06:01 [medline]
AID - 10.4061/2011/907961 [doi]
PST - ppublish
SO  - Stem Cells Int. 2011;2011:907961. doi: 10.4061/2011/907961. Epub 2011 Jun 19.


PMID- 21775875
OWN - NLM
STAT- MEDLINE
DCOM- 20110921
LR  - 20210107
IS  - 1873-233X (Electronic)
IS  - 0029-7844 (Linking)
VI  - 118
IP  - 2 Pt 1
DP  - 2011 Aug
TI  - Committee opinion no. 501: Maternal-fetal intervention and fetal care centers.
PG  - 405-410
LID - 10.1097/AOG.0b013e31822c99af [doi]
AB  - The past two decades have yielded profound advances in the fields of prenatal
      diagnosis and fetal intervention. Although fetal interventions are driven by a
      beneficence-based motivation to improve fetal and neonatal outcomes, advancement 
      in fetal therapies raises ethical issues surrounding maternal autonomy and
      decision making, concepts of innovation versus research, and organizational
      aspects within institutions in the development of fetal care centers. To
      safeguard the interests of both the pregnant woman and the fetus, the American
      College of Obstetricians and Gynecologists and the American Academy of Pediatrics
      make recommendations regarding informed consent, the role of research subject
      advocates and other independent advocates, the availability of support services, 
      the multidisciplinary nature of fetal intervention teams, the oversight of
      centers, and the need to accumulate maternal and fetal outcome data.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Obstet Gynecol
JT  - Obstetrics and gynecology
JID - 0401101
SB  - IM
MH  - Abortion, Eugenic
MH  - Female
MH  - Fetal Diseases/diagnosis/*therapy
MH  - Humans
MH  - Informed Consent
MH  - Patient Education as Topic
MH  - Patient Preference
MH  - Pregnancy
MH  - *Prenatal Care
MH  - *Prenatal Diagnosis
MH  - Research Subjects
MH  - Risk Assessment
EDAT- 2011/07/22 06:00
MHDA- 2011/09/22 06:00
CRDT- 2011/07/22 06:00
PHST- 2011/07/22 06:00 [entrez]
PHST- 2011/07/22 06:00 [pubmed]
PHST- 2011/09/22 06:00 [medline]
AID - 10.1097/AOG.0b013e31822c99af [doi]
AID - 00006250-201108000-00046 [pii]
PST - ppublish
SO  - Obstet Gynecol. 2011 Aug;118(2 Pt 1):405-410. doi: 10.1097/AOG.0b013e31822c99af.


PMID- 21775874
OWN - NLM
STAT- MEDLINE
DCOM- 20110921
LR  - 20210107
IS  - 1873-233X (Electronic)
IS  - 0029-7844 (Linking)
VI  - 118
IP  - 2 Pt 1
DP  - 2011 Aug
TI  - Committee opinion no. 500: Professional responsibilities in obstetric-gynecologic
      medical education and training.
PG  - 400-404
LID - 10.1097/AOG.0b013e31822c999a [doi]
AB  - The education of health care professionals is essential to maintaining standards 
      of medical competence and access to care by patients. Inherent in the education
      of health care professionals is the problem of disparity in power and authority, 
      including the power of teachers over learners and the power of practitioners over
      patients. Although there is a continuum of supervision levels and independence
      from student to resident to fellow, the ethical issues that arise during
      interactions among all teachers, learners, and their patients are similar. In
      this Committee Opinion, the Committee on Ethics of the American College of
      Obstetricians and Gynecologists discusses and offers recommendations regarding
      the professional conduct and ethical responsibilities of practitioners toward
      patients and participants in research in educational settings; of learners and
      teachers toward one another; and of institutions toward patients, learners, and
      teachers.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Obstet Gynecol
JT  - Obstetrics and gynecology
JID - 0401101
SB  - IM
MH  - Education, Medical/*ethics
MH  - Ethics, Institutional
MH  - Ethics, Medical/education
MH  - Gynecology/*education
MH  - Humans
MH  - Obstetrics/*education
MH  - Students, Medical
EDAT- 2011/07/22 06:00
MHDA- 2011/09/22 06:00
CRDT- 2011/07/22 06:00
PHST- 2011/07/22 06:00 [entrez]
PHST- 2011/07/22 06:00 [pubmed]
PHST- 2011/09/22 06:00 [medline]
AID - 10.1097/AOG.0b013e31822c999a [doi]
AID - 00006250-201108000-00045 [pii]
PST - ppublish
SO  - Obstet Gynecol. 2011 Aug;118(2 Pt 1):400-404. doi: 10.1097/AOG.0b013e31822c999a.


PMID- 21775855
OWN - NLM
STAT- MEDLINE
DCOM- 20110921
LR  - 20210107
IS  - 1873-233X (Electronic)
IS  - 0029-7844 (Linking)
VI  - 118
IP  - 2 Pt 1
DP  - 2011 Aug
TI  - Obstetric ethics: an essential dimension of planned home birth.
PG  - 357
LID - 10.1097/AOG.0b013e31822678ed [doi]
FAU - Plante, Lauren A
AU  - Plante LA
AD  - Departments of Obstetrics & Gynecology and Anesthesiology, Drexel University
      College of Medicine, Philadelphia PA.
LA  - eng
PT  - Comment
PT  - Letter
PL  - United States
TA  - Obstet Gynecol
JT  - Obstetrics and gynecology
JID - 0401101
SB  - IM
CON - Obstet Gynecol. 2011 May;117(5):1183-7. PMID: 21508761
MH  - Counseling
MH  - Female
MH  - Home Childbirth/*ethics
MH  - Humans
MH  - Obstetrics/*ethics
MH  - Patient Participation
MH  - Pregnancy
EDAT- 2011/07/22 06:00
MHDA- 2011/09/22 06:00
CRDT- 2011/07/22 06:00
PHST- 2011/07/22 06:00 [entrez]
PHST- 2011/07/22 06:00 [pubmed]
PHST- 2011/09/22 06:00 [medline]
AID - 10.1097/AOG.0b013e31822678ed [doi]
AID - 00006250-201108000-00023 [pii]
PST - ppublish
SO  - Obstet Gynecol. 2011 Aug;118(2 Pt 1):357. doi: 10.1097/AOG.0b013e31822678ed.


PMID- 21775854
OWN - NLM
STAT- MEDLINE
DCOM- 20110921
LR  - 20210107
IS  - 1873-233X (Electronic)
IS  - 0029-7844 (Linking)
VI  - 118
IP  - 2 Pt 1
DP  - 2011 Aug
TI  - Obstetric ethics: an essential dimension in planned home birth.
PG  - 357
LID - 10.1097/AOG.0b013e3182267ab1 [doi]
FAU - Fogelson, Nicholas S
AU  - Fogelson NS
AD  - Department of Obstetrics and Gynecology, University of South Carolina School of
      Medicine, Columbia, South Carolina (Fogelson) Stuart Fischbein, MD, 10309 Santa
      Monica Blve St 300, Los Angeles, California (Fischbein).
FAU - Fischbein, Stuart
AU  - Fischbein S
LA  - eng
PT  - Comment
PT  - Letter
PL  - United States
TA  - Obstet Gynecol
JT  - Obstetrics and gynecology
JID - 0401101
SB  - IM
CON - Obstet Gynecol. 2011 May;117(5):1183-7. PMID: 21508761
MH  - Delivery, Obstetric/adverse effects/ethics
MH  - Female
MH  - Home Childbirth/*ethics
MH  - Humans
MH  - Informed Consent/ethics
MH  - Obstetrics/*ethics
MH  - Pregnancy
EDAT- 2011/07/22 06:00
MHDA- 2011/09/22 06:00
CRDT- 2011/07/22 06:00
PHST- 2011/07/22 06:00 [entrez]
PHST- 2011/07/22 06:00 [pubmed]
PHST- 2011/09/22 06:00 [medline]
AID - 10.1097/AOG.0b013e3182267ab1 [doi]
AID - 00006250-201108000-00024 [pii]
PST - ppublish
SO  - Obstet Gynecol. 2011 Aug;118(2 Pt 1):357. doi: 10.1097/AOG.0b013e3182267ab1.


PMID- 21775618
OWN - NLM
STAT- MEDLINE
DCOM- 20120515
LR  - 20110721
IS  - 1708-8283 (Electronic)
IS  - 0883-0738 (Linking)
VI  - 26
IP  - 8
DP  - 2011 Aug
TI  - Family interventions to prevent maltreatment of children with disabilities.
PG  - 1052-3
LID - 10.1177/0883073811413279 [doi]
AB  - In addition to the challenges inherent to physical and cognitive impairments,
      children with disabilities are at high risk of exhibiting behavioral and
      emotional problems. Consequently, their parents are under undo stress, which in
      some instances may lead to child abuse. Specifically, children with disabilities 
      are 3 to 4 times more likely to be abused than are their normally developing
      peers. This alarming statistic is a consequence of a set of interrelated factors 
      that include the child, the disability, the family, and the socioeconomic
      environment where they live. In this installment of Ethical Crossroads, Murphy
      examines those factors. She ends her commentary by emphasizing the importance of 
      recognizing the caregivers' needs. In her mind, patient-focused rehabilitation
      interventions fall short of the mark. Instead, providing support to the family
      unit is a more fitting approach to the multidisciplinary care of a child with
      disabilities.
FAU - Weisleder, Pedro
AU  - Weisleder P
AD  - 1Nationwide Children's Hospital, Columbus, OH 43205, USA. weisleder.1@osu.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Child Neurol
JT  - Journal of child neurology
JID - 8606714
SB  - IM
MH  - Attention Deficit and Disruptive Behavior Disorders/therapy
MH  - Caregivers/*education/psychology
MH  - Child
MH  - Child Abuse/*prevention & control
MH  - Disabled Children/*psychology
MH  - Family/*psychology
MH  - Humans
MH  - *Parent-Child Relations
MH  - Practice Guidelines as Topic
EDAT- 2011/07/22 06:00
MHDA- 2012/05/16 06:00
CRDT- 2011/07/22 06:00
PHST- 2011/07/22 06:00 [entrez]
PHST- 2011/07/22 06:00 [pubmed]
PHST- 2012/05/16 06:00 [medline]
AID - 26/8/1052 [pii]
AID - 10.1177/0883073811413279 [doi]
PST - ppublish
SO  - J Child Neurol. 2011 Aug;26(8):1052-3. doi: 10.1177/0883073811413279.


PMID- 21775417
OWN - NLM
STAT- MEDLINE
DCOM- 20111011
LR  - 20211020
IS  - 1477-9129 (Electronic)
IS  - 0950-1991 (Linking)
VI  - 138
IP  - 17
DP  - 2011 Sep
TI  - Waves of early transcriptional activation and pluripotency program initiation
      during human preimplantation development.
PG  - 3699-709
LID - 10.1242/dev.064741 [doi]
AB  - The events regulating human preimplantation development are still largely unknown
      owing to a scarcity of material, ethical and legal limitations and a lack of
      reliable techniques to faithfully amplify the transcriptome of a single cell.
      Nonetheless, human embryology is gathering renewed interest due to its close
      relationship with both stem cell biology and epigenetic reprogramming to
      pluripotency and their importance in regenerative medicine. Carefully timed
      genome-wide transcript analyses of single oocytes and embryos uncovered a series 
      of successive waves of embryonic transcriptional initiation that start as early
      as the 2-cell stage. In addition, we identified the hierarchical activation of
      genes involved in the regulation of pluripotency. Finally, we developed HumER, a 
      database of human preimplantation gene expression, to serve the scientific
      community. Importantly, our work links early transcription in the human embryo
      with the correct execution of the pluripotency program later in development and
      paves the way for the identification of factors to improve epigenetic
      reprogramming.
FAU - Vassena, Rita
AU  - Vassena R
AD  - Center for Regenerative Medicine in Barcelona, CMR[B], Dr Aiguader 88, 08003,
      Barcelona, Spain.
FAU - Boue, Stephanie
AU  - Boue S
FAU - Gonzalez-Roca, Eva
AU  - Gonzalez-Roca E
FAU - Aran, Begona
AU  - Aran B
FAU - Auer, Herbert
AU  - Auer H
FAU - Veiga, Anna
AU  - Veiga A
FAU - Izpisua Belmonte, Juan Carlos
AU  - Izpisua Belmonte JC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110720
PL  - England
TA  - Development
JT  - Development (Cambridge, England)
JID - 8701744
SB  - IM
MH  - Adult
MH  - Blastocyst/*metabolism
MH  - Embryonic Development/genetics/*physiology
MH  - Female
MH  - Gene Expression Regulation, Developmental/genetics/physiology
MH  - Humans
MH  - Immunohistochemistry
MH  - Oocytes/cytology/metabolism
MH  - Polymerase Chain Reaction
MH  - Pregnancy
MH  - Transcriptional Activation/genetics/*physiology
MH  - Young Adult
PMC - PMC4074286
EDAT- 2011/07/22 06:00
MHDA- 2011/10/12 06:00
CRDT- 2011/07/22 06:00
PHST- 2011/07/22 06:00 [entrez]
PHST- 2011/07/22 06:00 [pubmed]
PHST- 2011/10/12 06:00 [medline]
AID - dev.064741 [pii]
AID - 10.1242/dev.064741 [doi]
PST - ppublish
SO  - Development. 2011 Sep;138(17):3699-709. doi: 10.1242/dev.064741. Epub 2011 Jul
      20.


PMID- 21775391
OWN - NLM
STAT- MEDLINE
DCOM- 20120227
LR  - 20181023
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 343
DP  - 2011 Jul 20
TI  - The medical ethics of the battlefield.
PG  - d3877
LID - 10.1136/bmj.d3877 [doi]
LID - bmj.d3877 [pii]
FAU - Sokol, Daniel K
AU  - Sokol DK
AD  - Imperial College London. daniel.sokol@talk21.com
LA  - eng
PT  - Journal Article
DEP - 20110720
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
SB  - IM
MH  - Emergency Medical Services/*ethics
MH  - Ethics, Medical
MH  - Humans
MH  - Military Medicine/*ethics
MH  - Patient Transfer/ethics
MH  - Warfare/*ethics
MH  - Wounds and Injuries/*therapy
EDAT- 2011/07/22 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/07/22 06:00
PHST- 2011/07/22 06:00 [entrez]
PHST- 2011/07/22 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - 10.1136/bmj.d3877 [doi]
PST - epublish
SO  - BMJ. 2011 Jul 20;343:d3877. doi: 10.1136/bmj.d3877.


PMID- 21775211
OWN - NLM
STAT- MEDLINE
DCOM- 20120112
LR  - 20220408
IS  - 1472-6491 (Electronic)
IS  - 1472-6483 (Linking)
VI  - 23
IP  - 3
DP  - 2011 Sep
TI  - Social egg freezing: the prospect of reproductive 'immortality' or a dangerous
      delusion?
PG  - 334-40
LID - 10.1016/j.rbmo.2011.05.010 [doi]
AB  - Until recently there was little to offer young women with cancer facing
      chemotherapy, radiotherapy or surgery and the probability of premature menopause 
      and sterility. The first 'frozen egg' baby was born in 1986, but success rates
      were so low that egg freezing was neglected. Three technological developments in 
      assisted reproduction treatment (intracytoplasmic sperm injection,
      dehydro-cryoprotectants and vitrification) have transformed this picture and now 
      young women with frozen eggs have the same probability of a live birth per embryo
      transfer as women undergoing conventional IVF. For many women it is not cancer
      but the passage of time that denies them a chance of motherhood. Social,
      educational and financial pressures often lead them to delay starting a family
      until their late thirties, by which time the chance of success is compromised by 
      low fecundity rates and an increased risk of miscarriage if they become pregnant.
      Donor eggs are not an option for many because of supply constraints and ethical
      concerns. Freezing a woman's eggs at age 30 literally 'freezes in time' her
      fertility potential and gives her the chance of a healthy pregnancy at a time of 
      her choosing. The role of oocyte cryopreservation in the context of social egg
      freezing is discussed. Until recently there was little we could offer young women
      with cancer facing the chemotherapy, radiotherapy or surgery that could save
      their lives and the certainty of premature menopause and sterility. The first
      frozen-egg baby was born in 1986, but the success rate (100 eggs to produce one
      baby) was so low that egg freezing was neglected for years. Three technological
      developments in assisted reproduction treatment (intracytoplasmic sperm
      injection, dehydro-cryoprotectants and vitrification) have transformed this
      picture and now young women who have cryopreserved eggs can be offered the same
      chance of a live birth per embryo transfer as women undergoing conventional IVF
      treatment. For many women today it is not cancer but the simple passage of time
      that robs them of their chance of motherhood. Social, educational, emotional and 
      financial pressures often lead them to delay trying to start a family until their
      late thirties, by which time the chance of success is very low. Women at age 40
      face a 40% chance of miscarriage if they can get pregnant at all and by the age
      of 45, the risk of miscarriage is 75%. Donor eggs are not an option for many
      because of supply constraints and ethical and cultural concerns. Freezing a
      woman's eggs at age 30 literally 'freezes in time' her fertility potential and
      gives her the chance of a healthy pregnancy at a time of her choosing. This paper
      discusses the role of oocyte cryopreservation in the context of social egg
      freezing.
CI  - Copyright (c) 2011 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All
      rights reserved.
FAU - Lockwood, Gillian M
AU  - Lockwood GM
AD  - Midland Fertility Services, Aldridge, UK. Gillian.lockwood@midlandfertility.com
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110527
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
SB  - IM
MH  - *Cryopreservation
MH  - Female
MH  - Fertility Preservation/*ethics
MH  - Humans
MH  - Male
MH  - Maternal Age
MH  - *Oocytes
MH  - Pregnancy
MH  - *Social Behavior
EDAT- 2011/07/22 06:00
MHDA- 2012/01/13 06:00
CRDT- 2011/07/22 06:00
PHST- 2010/09/01 00:00 [received]
PHST- 2011/05/18 00:00 [revised]
PHST- 2011/05/18 00:00 [accepted]
PHST- 2011/07/22 06:00 [entrez]
PHST- 2011/07/22 06:00 [pubmed]
PHST- 2012/01/13 06:00 [medline]
AID - S1472-6483(11)00283-5 [pii]
AID - 10.1016/j.rbmo.2011.05.010 [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2011 Sep;23(3):334-40. doi: 10.1016/j.rbmo.2011.05.010.
      Epub 2011 May 27.


PMID- 21775103
OWN - NLM
STAT- MEDLINE
DCOM- 20111227
LR  - 20220321
IS  - 1878-5921 (Electronic)
IS  - 0895-4356 (Linking)
VI  - 64
IP  - 12
DP  - 2011 Dec
TI  - Characteristics and quality of reporting of cluster randomized trials in
      children: reporting needs improvement.
PG  - 1331-40
LID - 10.1016/j.jclinepi.2011.04.006 [doi]
AB  - OBJECTIVE: To describe the characteristics and quality of reporting of cluster
      randomized trials (CRTs) in children published from 2004 to 2010. STUDY DESIGN
      AND SETTING: Four databases were searched for reports of CRTs in children (0-18
      years). Characteristics of the studies were summarized and the quality of
      reporting assessed using consolidated standards of reporting trial-CRT
      (CONSORT-CRT). RESULTS: Of 1,949 identified references, 106 were included. The
      number of published CRTs in children increased since 2004. The greatest
      proportion of CRTs was undertaken in Europe (29%), whereas 40% was conducted in
      low- and middle-income countries. Most studies were of complex rather than simple
      interventions (83%); were preventive rather than treatment interventions (76%);
      and most frequently addressed infectious disease (21%), diet/physical activity
      interventions (19%), health-risk behaviors (15%), and undernutrition (13%). The
      majority used schools as units of randomization (72%) and enrolled 1,000-10,000
      children per study (51%). Reporting was generally poor, with 34% of CRTs
      inadequately reporting on more than half of the CONSORT-CRT criteria. Although
      85% of CRTs reported that they had ethics approval for the study, consent or
      assent was not obtained from children in most studies. CONCLUSION:
      Children-specific elements of reporting are needed to improve the quality of
      reporting of CRTs and consequently their planning and implementation.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Walleser, Silke
AU  - Walleser S
AD  - Sur la Croix 189, 1020 Renens, Switzerland.
FAU - Hill, Suzanne R
AU  - Hill SR
FAU - Bero, Lisa A
AU  - Bero LA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110720
PL  - United States
TA  - J Clin Epidemiol
JT  - Journal of clinical epidemiology
JID - 8801383
SB  - IM
MH  - Bias
MH  - Child
MH  - *Cluster Analysis
MH  - Humans
MH  - Practice Guidelines as Topic
MH  - Publishing/*standards
MH  - *Quality Control
MH  - Randomized Controlled Trials as Topic/*standards
MH  - Research Design/*standards
MH  - Switzerland
EDAT- 2011/07/22 06:00
MHDA- 2011/12/28 06:00
CRDT- 2011/07/22 06:00
PHST- 2011/01/05 00:00 [received]
PHST- 2011/03/12 00:00 [revised]
PHST- 2011/04/17 00:00 [accepted]
PHST- 2011/07/22 06:00 [entrez]
PHST- 2011/07/22 06:00 [pubmed]
PHST- 2011/12/28 06:00 [medline]
AID - S0895-4356(11)00125-9 [pii]
AID - 10.1016/j.jclinepi.2011.04.006 [doi]
PST - ppublish
SO  - J Clin Epidemiol. 2011 Dec;64(12):1331-40. doi: 10.1016/j.jclinepi.2011.04.006.
      Epub 2011 Jul 20.


PMID- 21774933
OWN - NLM
STAT- MEDLINE
DCOM- 20120313
LR  - 20220309
IS  - 1873-491X (Electronic)
IS  - 0020-7489 (Linking)
VI  - 48
IP  - 12
DP  - 2011 Dec
TI  - Negotiated dying: a grounded theory of how nurses shape withdrawal of treatment
      in hospital critical care units.
PG  - 1466-74
LID - 10.1016/j.ijnurstu.2011.06.003 [doi]
AB  - BACKGROUND: The process of withdrawal of treatment in critical care environments 
      has created ethical and moral dilemmas in relation to end of life care in the UK 
      and elsewhere. Common within this discourse is the differing demands made on
      health professionals as they strive to provide care for the dying patient and
      family members. Despite reports that withdrawal of treatment is a source of
      tension between those nurses and doctors involved in the process, the role of the
      nurse in facilitating withdrawal of treatment has received relatively little
      attention. OBJECTIVES: To illustrate how differing dying trajectories impact on
      decision-making underpinning withdrawal of treatment processes, and what nurses
      do to shape withdrawal of treatment. DESIGN: Qualitative methods of enquiry using
      clinical vignettes and applying Charmaz's grounded theory method. METHODS AND
      SETTINGS: Single audio-recorded qualitative interviews with thirteen critical
      care nurses from four intensive care specialities: cardiac; general; neurological
      and renal were carried out. Interviews were facilitated by an end-of-life
      vignette developed with clinical collaborators. FINDINGS: Across critical care
      areas four key dying trajectories were identified. These trajectories were shaped
      by contested boundaries associated with delayed or stalled decision-making around
      how withdrawal of treatment should proceed. Nurses provided end of life care
      (including collaborative and action-oriented skills) to shape the dying
      trajectory of patients so as to satisfy the wishes of the patient and family, and
      their own professional aims. CONCLUSIONS: Differing views as to when withdrawal
      of treatment should commence and how it should be operationalised appeared to be 
      underpinned by the requirements of the role that health professionals fulfil,
      with doctors focusing on making withdrawal of treatment decisions, and nurse's
      being tasked with operationalising the processes that constitute it.
      Multidisciplinary teams need a 'shared' understanding of each other's roles,
      responsibilities, aims, and motivations when planning and implementing the dying 
      trajectory of withdrawal of treatment.
CI  - 2011 Elsevier Ltd. All rights reserved.
FAU - Long-Sutehall, Tracy
AU  - Long-Sutehall T
AD  - Faculty of Health Sciences, Building 67, University of Southampton, Southampton
      SO17 1BJ, United Kingdom. T.Long@soton.ac.uk
FAU - Willis, Helen
AU  - Willis H
FAU - Palmer, Rachel
AU  - Palmer R
FAU - Ugboma, Debra
AU  - Ugboma D
FAU - Addington-Hall, Julia
AU  - Addington-Hall J
FAU - Coombs, Maureen
AU  - Coombs M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110719
PL  - England
TA  - Int J Nurs Stud
JT  - International journal of nursing studies
JID - 0400675
SB  - IM
MH  - *Critical Care
MH  - *Death
MH  - Humans
MH  - *Negotiating
MH  - *Nursing Staff, Hospital
EDAT- 2011/07/22 06:00
MHDA- 2012/03/14 06:00
CRDT- 2011/07/22 06:00
PHST- 2010/09/21 00:00 [received]
PHST- 2011/06/09 00:00 [revised]
PHST- 2011/06/14 00:00 [accepted]
PHST- 2011/07/22 06:00 [entrez]
PHST- 2011/07/22 06:00 [pubmed]
PHST- 2012/03/14 06:00 [medline]
AID - S0020-7489(11)00258-6 [pii]
AID - 10.1016/j.ijnurstu.2011.06.003 [doi]
PST - ppublish
SO  - Int J Nurs Stud. 2011 Dec;48(12):1466-74. doi: 10.1016/j.ijnurstu.2011.06.003.
      Epub 2011 Jul 19.


PMID- 21774785
OWN - NLM
STAT- MEDLINE
DCOM- 20120514
LR  - 20210804
IS  - 1873-4286 (Electronic)
IS  - 1381-6128 (Linking)
VI  - 17
IP  - 21
DP  - 2011
TI  - Retraction Notice: Tocotrienols and its Role in Cardiovascular Health- a Lead for
      Drug Design
PG  - 2170-5
AB  - The article has been retracted by the Editorial office of the journal Current
      Pharmaceutical Design, due to some inconsistencies in the article [1]. The
      article appeared to be copied verbatim from published papers. Upon checking these
      facts, we have established that considerable portions of this review are made up 
      of text copied verbatim from other published material. The Publisher has
      retracted this article in accordance with good ethical practices. REFERENCE: [1] 
      Vasanthi HR, Parameswari RP and Das DK. Tocotrienols and its Role in
      Cardiovascular Health- a Lead for Drug Design. Curr Pharm Des 2011; 17(21):
      2170-5. Bentham Science apologizes to the readers of the journal for any
      inconvenience this may have caused. The Bentham Editorial Policy on Article
      Retraction can be found at
      https://benthamscience.com/editorial-policies-main.php. Bentham Science
      Disclaimer: It is a condition of publication that manuscripts submitted to this
      journal have not been published and will not be simultaneously submitted or
      published elsewhere. Furthermore, any data, illustration, structure or table that
      has been published elsewhere must be reported, and copyright permission for
      reproduction must be obtained. Plagiarism is strictly forbidden, and by
      submitting the article for publication the authors agree that the publishers have
      the legal right to take appropriate action against the authors, if plagiarism or 
      fabricated information is discovered. By submitting a manuscript, the authors
      agree that the copyright of their article is transferred to the publishers if and
      when the article is accepted for publication.
FAU - Vasanthi, Hannah R
AU  - Vasanthi HR
AD  - Department of Biotechnology, School of Life Sciences, Pondicherry University,
      Puducherry-605014, India. hrvasanthi@gmail.com
FAU - Parameswari, R P
AU  - Parameswari RP
FAU - Das, Dipak K
AU  - Das DK
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Retracted Publication
PL  - United Arab Emirates
TA  - Curr Pharm Des
JT  - Current pharmaceutical design
JID - 9602487
RN  - 0 (Antioxidants)
RN  - 0 (Lipids)
RN  - 0 (Tocotrienols)
SB  - IM
RIN - Curr Pharm Des. 2021;27(16):1973. PMID: 34259133
MH  - Animals
MH  - Antioxidants/administration & dosage/adverse effects/*therapeutic use
MH  - Cardiovascular Diseases/blood/etiology/*prevention & control
MH  - Diabetes Mellitus/blood/drug therapy
MH  - *Drug Design
MH  - Humans
MH  - Hypercholesterolemia/blood/complications/drug therapy
MH  - Lipid Metabolism/drug effects
MH  - Lipids/blood
MH  - Obesity/blood/complications/drug therapy
MH  - Risk Factors
MH  - Tocotrienols/administration & dosage/adverse effects/*therapeutic use
EDAT- 2011/07/22 06:00
MHDA- 2012/05/15 06:00
CRDT- 2011/07/22 06:00
PHST- 2011/06/02 00:00 [received]
PHST- 2011/06/21 00:00 [accepted]
PHST- 2011/07/22 06:00 [entrez]
PHST- 2011/07/22 06:00 [pubmed]
PHST- 2012/05/15 06:00 [medline]
AID - BSP/CPD/E-Pub/000531 [pii]
AID - 10.2174/138161211796957508 [doi]
PST - ppublish
SO  - Curr Pharm Des. 2011;17(21):2170-5. doi: 10.2174/138161211796957508.


PMID- 21774288
OWN - NLM
STAT- MEDLINE
DCOM- 20110929
LR  - 20131121
IS  - 0125-2208 (Print)
IS  - 0125-2208 (Linking)
VI  - 94
IP  - 7
DP  - 2011 Jul
TI  - Predicted EC50 of propofol using target controlled infusion with and without
      fentanyl for colonoscopy.
PG  - 813-8
AB  - OBJECTIVE: To determine the propofol effect site target concentration at which
      50% of patients did not respond to stimulation for colonoscopy (EC50colonoscopy) 
      using a target controlled infusion (Schnider model) and to investigate whether
      fentanyl reduces these required concentrations. MATERIAL AND METHOD: Subsequent
      to an approval from the institute medical ethics committee, 40 unpremedicated
      patients, ASA physical status 1-2, aged 18-70 years, BMI less than 30 kg/m2 and
      scheduled for elective colonoscopy were randomly assigned to a saline-propofol
      group (control group) or a 1 mcg/kg fentanyl-propofol group (fentanyl group).
      Propofol was initiated using a target controlled infusion. Initial effect site
      target concentration (EC) administered to the first patient in each group were
      2.5 mcg/ml. For each subsequent patient, EC was determined by the response of the
      previous patient by the Dixon's up-and-down method (with 0.5 mcg/ml as a step
      size). Individual patient response to colonoscopy was described as no movement'
      or 'movement'. EC50colonoscopy values were obtained by calculating the mean of 20
      patients in each group. RESULTS: The patient demographic data were not
      significantly different between the two groups. Total propofol dose in the
      control group was also significantly higher than that in the fentanyl group. The 
      values for EC50colonoscopy were 3.25 +/- 0.47 mcg/ ml in the control group and
      2.65 +/- 0.40 mcg/ml in the fentanyl group (p = 0.00). CONCLUSION: The propofol
      EC50 for colonoscopy was decreased by supplemental 1 mcg/kg fentanyl with no
      significant difference in hemodynamic values between the two groups.
FAU - Thaharavanich, Russana
AU  - Thaharavanich R
AD  - Department of Anesthesiology, Charoenkrung Pracharak Hospital, Bangkok, Thailand.
      russana2000@hotmail.com
FAU - Sintavanuruk, Krairerk
AU  - Sintavanuruk K
FAU - Laosuwan, Surajak
AU  - Laosuwan S
FAU - Pongruekdee, Sukanya
AU  - Pongruekdee S
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Thailand
TA  - J Med Assoc Thai
JT  - Journal of the Medical Association of Thailand = Chotmaihet thangphaet
JID - 7507216
RN  - 0 (Anesthetics, Intravenous)
RN  - UF599785JZ (Fentanyl)
RN  - YI7VU623SF (Propofol)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Anesthetics, Intravenous/*administration & dosage
MH  - Colonoscopy/*methods
MH  - Consciousness/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Fentanyl/*administration & dosage
MH  - Hemodynamics/drug effects
MH  - Humans
MH  - Infusions, Intravenous
MH  - Male
MH  - Middle Aged
MH  - Propofol/*administration & dosage
MH  - Young Adult
EDAT- 2011/07/22 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/07/22 06:00
PHST- 2011/07/22 06:00 [entrez]
PHST- 2011/07/22 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
PST - ppublish
SO  - J Med Assoc Thai. 2011 Jul;94(7):813-8.


PMID- 21774277
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20181201
IS  - 1320-159X (Print)
IS  - 1320-159X (Linking)
VI  - 18
IP  - 4
DP  - 2011 Jun
TI  - Defending the sanctity of life principle: a reply to John Keown.
PG  - 820-34
AB  - This article is a response to Professor John Keown's criticism of my article
      "Finding a Way Through the Ethical and Legal Maze: Withdrawal of Medical
      Treatment and Euthanasia" (2005) 13(3) Medical Law Review 357. The article takes 
      up and responds to a number of criticisms raised by Keown in an attempt to
      further the debate concerning the moral and legal status of withdrawing
      life-sustaining measures, its distinction from euthanasia, and the implications
      of the lawfulness of withdrawal for the principle of the sanctity of life.
FAU - McGee, Andrew
AU  - McGee A
AD  - Queensland University of Technology. a.mcgee@qut.edu.au
LA  - eng
PT  - Journal Article
PT  - Legal Case
PL  - Australia
TA  - J Law Med
JT  - Journal of law and medicine
JID - 9431853
SB  - IM
MH  - Euthanasia/ethics/*legislation & jurisprudence
MH  - Humans
MH  - Medical Futility
MH  - Quality of Life
MH  - Withholding Treatment/ethics/*legislation & jurisprudence
EDAT- 2011/07/22 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/07/22 06:00
PHST- 2011/07/22 06:00 [entrez]
PHST- 2011/07/22 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
PST - ppublish
SO  - J Law Med. 2011 Jun;18(4):820-34.


PMID- 21774270
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20110721
IS  - 1320-159X (Print)
IS  - 1320-159X (Linking)
VI  - 18
IP  - 4
DP  - 2011 Jun
TI  - An ethical protocol for complementary and alternative medicine practitioners in
      an orthodox medicine regime.
PG  - 728-36
AB  - Concern that has been expressed about the provision of complementary and
      alternative medicine (CAM) in an orthodox medicine context with regard to the
      possibility of a client not being referred to the latter when the condition is
      readily dealt with by it. There have been some negative outcomes for clients when
      orthodox medicine has not been used when it was clearly indicated. Complementary 
      and alternative medicine has many strengths for clients but it behoves a CAM
      practitioner to consider circumstances when it is appropriate to refer a client
      to orthodox medicine or to work in a complementary manner with orthodox medicine.
      This article suggests some guidelines that CAM practitioners should consider when
      assessing the circumstances when referral to orthodox medicine is indicated to
      support ethical practice for the benefit of the client.
FAU - Weir, Michael
AU  - Weir M
AD  - Faculty of Law, Bond University, Gold Coast, Australia. Michael_weir@bond.edu.au
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Law Med
JT  - Journal of law and medicine
JID - 9431853
SB  - IM
MH  - *Clinical Protocols
MH  - Complementary Therapies/*ethics
MH  - Humans
MH  - *Referral and Consultation
EDAT- 2011/07/22 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/07/22 06:00
PHST- 2011/07/22 06:00 [entrez]
PHST- 2011/07/22 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
PST - ppublish
SO  - J Law Med. 2011 Jun;18(4):728-36.


PMID- 21774269
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20110721
IS  - 1320-159X (Print)
IS  - 1320-159X (Linking)
VI  - 18
IP  - 4
DP  - 2011 Jun
TI  - Where to now for health-related journal peer review?
PG  - 724-7
AB  - Peer review of health-related manuscripts has enormous power in determining what 
      is published in health-related journals, and what makes its way into health
      policy and clinical practice. However, peer review is at times ethically
      problematic and not always effective in achieving its goals. Over the past 25
      years, a large number of debates about, and studies of, the peer review process
      has been published. Despite this, there is limited agreement about the strengths 
      and weaknesses of peer review, and limited evidence about whether peer review
      achieves its goals and whether interventions to improve it have been successful. 
      The authors argue that this state of affairs is not acceptable and that there is 
      a need to systematise efforts to understand and improve the review process.
FAU - Lipworth, Wendy
AU  - Lipworth W
AD  - Centre for Values, Ethics and the Law in Medicine, University of Sydney, NSW,
      Australia. Wendy.lipworth@sydney.edu.au
FAU - Kerridge, Ian
AU  - Kerridge I
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Law Med
JT  - Journal of law and medicine
JID - 9431853
SB  - IM
MH  - Editorial Policies
MH  - Humans
MH  - *Peer Review, Research
MH  - Publishing/*ethics/standards
EDAT- 2011/07/22 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/07/22 06:00
PHST- 2011/07/22 06:00 [entrez]
PHST- 2011/07/22 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
PST - ppublish
SO  - J Law Med. 2011 Jun;18(4):724-7.


PMID- 21774265
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20110721
IS  - 1320-159X (Print)
IS  - 1320-159X (Linking)
VI  - 18
IP  - 4
DP  - 2011 Jun
TI  - The death of a living soul.
PG  - 695-700
AB  - We are bedevilled with varying definitions of death, ranging from higher brain
      death to cardiovascular or somatic death. They all try to capture what is
      essential to our reasoning about the importance of human death. This column
      argues that what they all neglect is the Aristotelian inspiration of many of the 
      attempts at reformulation of the definition. Aristotle's work on the soul focuses
      on the loving soul as the form of humanity that makes human living and dying the 
      morally significant phenomenon that engages law-makers and ethicists alike. The
      form of humanity comprises a holistic package of properties which cannot be dealt
      with in a reductive manner and which our criteria for death must answer to. When 
      that is clarified, the role of these criteria and their importance both become
      more transparent.
FAU - Gillett, Grant
AU  - Gillett G
AD  - Dunedin Hospital and Otago Bioethics Centre, University of Otago Medical School, 
      New Zealand. grant.gillett@stonebow.otago.ac.nz
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Law Med
JT  - Journal of law and medicine
JID - 9431853
SB  - IM
MH  - Bioethical Issues
MH  - Brain Death/*legislation & jurisprudence
MH  - Humans
MH  - Persistent Vegetative State
MH  - Tissue and Organ Procurement/ethics/*legislation & jurisprudence
EDAT- 2011/07/22 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/07/22 06:00
PHST- 2011/07/22 06:00 [entrez]
PHST- 2011/07/22 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
PST - ppublish
SO  - J Law Med. 2011 Jun;18(4):695-700.


PMID- 21774053
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20110720
IS  - 1539-3429 (Electronic)
IS  - 1470-8175 (Linking)
VI  - 39
IP  - 4
DP  - 2011 Jul
TI  - The ethical implications of genetic testing in the classroom.
PG  - 253-60
LID - 10.1002/bmb.20521 [doi]
AB  - The development of classroom experiments where students examine their own DNA is 
      frequently described as an innovative teaching practice. Often these experiences 
      involve students analyzing their genes for various polymorphisms associated with 
      disease states, like an increased risk for developing cancer. Such experiments
      can muddy the distinction between classroom investigation and medical testing.
      Although the goals and issues surrounding classroom genotyping do not directly
      align with those of clinical testing, instructors can use the guidelines and
      standards established by the medical genetics community when evaluating the
      ethics of human genotyping. We developed a laboratory investigation and
      discussion which allowed undergraduate science students to explore current DNA
      manipulation techniques to isolate their p53 gene, followed by a dialogue probing
      the ethical implications of examining their sample for various polymorphisms.
      Students never conducted genotyping on their samples because of the ethical
      concerns presented in this paper, so the discussion replaced the actual genetic
      testing in the class. A science faculty member led the laboratory portion, while 
      a genetic counselor facilitated the discussion of the ethical concepts underlying
      genetic counseling: autonomy, beneficence, confidentiality, and justice. In their
      final papers, students demonstrated an understanding of the practice guidelines
      established by the genetics community and acknowledged the ethical considerations
      inherent in p53 genotyping. Given the burgeoning market for personalized
      medicine, teaching undergraduates about the psychosocial and ethical dimensions
      of human genetic testing is important and timely. Moreover, incorporating a
      genetic counselor in the classroom discussion provided a rich and dynamic
      discussion of human genetic testing.
CI  - Copyright (c) 2011 Wiley Periodicals, Inc.
FAU - Taylor, Ann T S
AU  - Taylor AT
AD  - Department of Chemistry, Wabash College, Crawfordsville, Indiana 47933, USA.
      taylora@wabash.edu
FAU - Rogers, Jill Cellars
AU  - Rogers JC
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Biochem Mol Biol Educ
JT  - Biochemistry and molecular biology education : a bimonthly publication of the
      International Union of Biochemistry and Molecular Biology
JID - 100970605
SB  - IM
MH  - Beneficence
MH  - Bioethics/*education
MH  - Confidentiality/*ethics
MH  - Education, Medical
MH  - Ethics
MH  - Ethics, Medical/*education
MH  - Genetic Counseling/ethics
MH  - Genetic Testing/*methods
MH  - Humans
MH  - *Personal Autonomy
MH  - Polymorphism, Genetic
MH  - Social Justice/*ethics
MH  - Students
MH  - United States
EDAT- 2011/07/21 06:00
MHDA- 2011/11/09 06:00
CRDT- 2011/07/21 06:00
PHST- 2011/07/21 06:00 [entrez]
PHST- 2011/07/21 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - 10.1002/bmb.20521 [doi]
PST - ppublish
SO  - Biochem Mol Biol Educ. 2011 Jul;39(4):253-60. doi: 10.1002/bmb.20521.


PMID- 21773956
OWN - NLM
STAT- MEDLINE
DCOM- 20120306
LR  - 20110913
IS  - 1438-8685 (Electronic)
IS  - 0935-8943 (Linking)
VI  - 90
IP  - 9
DP  - 2011 Sep
TI  - [The implementation of risk management in a department of otolaryngology].
PG  - 548-53
LID - 10.1055/s-0031-1280831 [doi]
AB  - The reasons for introducing risk management in hospitals are manifold. Not only
      legal but also ethical and moral aspects are of great importance.The
      implementation of risk management in a German department of otolaryngology is
      presented. Although various instruments were introduced, the main emphasis was
      placed on the establishment of a risk management team with the aim of
      prospectively and retrospectively addressing critical situations in hospital
      operation management and also with the goal of achieving a change of attitude
      towards mistakes, complications and damages in the clinic.Many aspects of the
      in-house processes were critically analyzed and optimization strategies were
      developed such as the introduction of checklists for preoperative patient
      identification. Furthermore the implemented CIRS has been well accepted.A
      meaningful objectivity of the results seems difficult. A main reason is that the 
      index "reduction of damage and medical malpractice" is too small to make a
      conclusive statistical analysis. However, implementation of risk management is
      advisable for every ENT clinic.
CI  - Georg Thieme Verlag KG Stuttgart . New York.
FAU - Teschner, M
AU  - Teschner M
AD  - Medizinische Hochschule Hannover, Klinik und Poliklinik fur Hals-, Nasen-,
      Ohrenheilkunde. teschner.magnus@mh-hannover.de
FAU - Cartes, M I
AU  - Cartes MI
FAU - Lenarz, T
AU  - Lenarz T
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Implementierung eines Risikomanagements in einer Hals-, Nasen-, Ohrenklinik.
DEP - 20110719
PL  - Germany
TA  - Laryngorhinootologie
JT  - Laryngo- rhino- otologie
JID - 8912371
SB  - IM
CIN - Laryngorhinootologie. 2011 Sep;90(9):535-6. PMID: 21913150
MH  - Checklist
MH  - Germany
MH  - Hospital Departments/*organization & administration
MH  - Humans
MH  - Inservice Training
MH  - Medical Errors/legislation & jurisprudence/prevention & control
MH  - National Health Programs/legislation & jurisprudence
MH  - Otolaryngology/legislation & jurisprudence/*organization & administration
MH  - Patient Safety
MH  - Risk Management/legislation & jurisprudence/*organization & administration
MH  - Task Performance and Analysis
EDAT- 2011/07/21 06:00
MHDA- 2012/03/07 06:00
CRDT- 2011/07/21 06:00
PHST- 2011/07/21 06:00 [entrez]
PHST- 2011/07/21 06:00 [pubmed]
PHST- 2012/03/07 06:00 [medline]
AID - 10.1055/s-0031-1280831 [doi]
PST - ppublish
SO  - Laryngorhinootologie. 2011 Sep;90(9):548-53. doi: 10.1055/s-0031-1280831. Epub
      2011 Jul 19.


PMID- 21773764
OWN - NLM
STAT- MEDLINE
DCOM- 20111121
LR  - 20220309
IS  - 1432-0614 (Electronic)
IS  - 0175-7598 (Linking)
VI  - 91
IP  - 5
DP  - 2011 Sep
TI  - In vitro maintenance of a human proximal colon microbiota using the continuous
      fermentation system P-ECSIM.
PG  - 1425-33
LID - 10.1007/s00253-011-3462-5 [doi]
AB  - Ethical and technical difficulties for in vivo studies on gut microbiotas argue
      for the development of alternative in vitro models: here, we describe a system
      simulating the proximal part of a human colon both nutritionally and
      physico-chemically with a procedure aimed to limit experimental variations over
      the time (Proximal Environmental Control System For Intestinal
      Microbiota--P-ECSIM). The continuous culture system P-ECSIM is first inoculated
      by a -20 degrees C glycerol stock established from the batch culture of a
      stool-inoculated medium. The anaerobic atmosphere is self-maintained by the gases
      produced in the ordinary metabolism of fermentations. The monitoring of metabolic
      activities and microbial constitutions indicates that different steady states are
      obtained according to the dilution rate. Finally, the glycerol conservation of
      the batch culture-derived inoculum gives a similar differential response between 
      the two dilution rates (D = 0.08 h(-)(1) and D = 0.04 h(-)(1)) after a 1-year
      storage time as well for their metabolism and constitution in steady states, but 
      with a lower abundance. Molecular fingerprints of the microbiota reveal however
      alterations over the time. Further efforts are needed concerning the preservation
      of standardized inoculums in order to improve the process for intra- and
      inter-lab comparison. Combined with appropriate analytical techniques, this
      system provides an efficient alternative means of studying functionally human
      microbiota in its constitution, metabolism and adaptation to environmental
      changes, particularly nutritional.
FAU - Feria-Gervasio, David
AU  - Feria-Gervasio D
AD  - Conception Ingenierie et Developpement de l'Aliment et du Medicament, Clermont
      Universite, Universite d'Auvergne, ERT 18-CIDAM, 28 Place Henri Dunant, BP 10448,
      63000 Clermont-Ferrand, France.
FAU - Denis, Sylvain
AU  - Denis S
FAU - Alric, Monique
AU  - Alric M
FAU - Brugere, Jean-Francois
AU  - Brugere JF
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110720
PL  - Germany
TA  - Appl Microbiol Biotechnol
JT  - Applied microbiology and biotechnology
JID - 8406612
RN  - 0 (Gases)
SB  - IM
MH  - Adult
MH  - Bacteria/growth & development/*metabolism
MH  - Colon/*microbiology/physiology
MH  - Culture Techniques/instrumentation/*methods
MH  - *Digestion
MH  - Feces/microbiology
MH  - Female
MH  - Fermentation
MH  - Gases/metabolism
MH  - Humans
MH  - *Metagenome
MH  - *Models, Biological
EDAT- 2011/07/21 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/21 06:00
PHST- 2011/04/29 00:00 [received]
PHST- 2011/06/22 00:00 [accepted]
PHST- 2011/06/20 00:00 [revised]
PHST- 2011/07/21 06:00 [entrez]
PHST- 2011/07/21 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/s00253-011-3462-5 [doi]
PST - ppublish
SO  - Appl Microbiol Biotechnol. 2011 Sep;91(5):1425-33. doi:
      10.1007/s00253-011-3462-5. Epub 2011 Jul 20.


PMID- 21772963
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20220330
IS  - 2042-0048 (Electronic)
IS  - 2042-0048 (Linking)
VI  - 2011
DP  - 2011
TI  - Methods of Control of the Leishmania infantum Dog Reservoir: State of the Art.
PG  - 215964
LID - 10.4061/2011/215964 [doi]
AB  - Leishmania infantum is a protozoan parasite causing severe vector-borne visceral 
      diseases both in humans and dogs. The latter are the most important natural
      reservoir and therefore should be the main target of control measures. The real
      efficacy of seropositive dogs culling as a direct control method is still
      debated, and the new sensitivity of large part of population considers ethically 
      unacceptable this kind of approach. Treatment of infectious dogs with one of the 
      available therapeutic protocols is recommendable as it allows to reduce parasite 
      burdens and therefore the possibility of transmission of Leishmania infantum to
      vectors. Vaccination has been proven to be a very effective control tool, but the
      absence of a commonly recognized diagnostic method able to distinguish vaccinate 
      from seropositive individuals is still an important limit. Concerning indirect
      control methods, a number of studies have demonstrated the efficacy of topical
      insecticides treatment (collars, spot-on, and sprays) in reducing incidence and
      prevalence of L. infantum. Also, the reduction of the odds of seroconversion in
      humans in endemic areas has been reported after the application of indirect
      control measures on dogs. The contemporary use of direct and indirect methods is 
      even more effective in reducing seroprevalence in dogs.
FAU - Podaliri Vulpiani, Michele
AU  - Podaliri Vulpiani M
AD  - Divisione Veterinaria di Salute Pubblica, Istituto "G. Caporale", Via Campo
      Boario, 64100 Teramo, Italy.
FAU - Iannetti, Luigi
AU  - Iannetti L
FAU - Paganico, Daniela
AU  - Paganico D
FAU - Iannino, Filomena
AU  - Iannino F
FAU - Ferri, Nicola
AU  - Ferri N
LA  - eng
PT  - Journal Article
DEP - 20110707
PL  - United States
TA  - Vet Med Int
JT  - Veterinary medicine international
JID - 101524203
PMC - PMC3134973
EDAT- 2011/07/21 06:00
MHDA- 2011/07/21 06:01
CRDT- 2011/07/21 06:00
PHST- 2010/10/29 00:00 [received]
PHST- 2011/04/02 00:00 [revised]
PHST- 2011/05/11 00:00 [accepted]
PHST- 2011/07/21 06:00 [entrez]
PHST- 2011/07/21 06:00 [pubmed]
PHST- 2011/07/21 06:01 [medline]
AID - 10.4061/2011/215964 [doi]
PST - ppublish
SO  - Vet Med Int. 2011;2011:215964. doi: 10.4061/2011/215964. Epub 2011 Jul 7.


PMID- 21772852
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1687-9678 (Electronic)
VI  - 2011
DP  - 2011
TI  - Epigenetic regulation of mesenchymal stem cells: a focus on osteogenic and
      adipogenic differentiation.
PG  - 201371
LID - 10.4061/2011/201371 [doi]
AB  - Stem cells are characterized by their capability to self-renew and terminally
      differentiate into multiple cell types. Somatic or adult stem cells have a finite
      self-renewal capacity and are lineage-restricted. The use of adult stem cells for
      therapeutic purposes has been a topic of recent interest given the ethical
      considerations associated with embryonic stem (ES) cells. Mesenchymal stem cells 
      (MSCs) are adult stem cells that can differentiate into osteogenic, adipogenic,
      chondrogenic, or myogenic lineages. Owing to their ease of isolation and unique
      characteristics, MSCs have been widely regarded as potential candidates for
      tissue engineering and repair. While various signaling molecules important to MSC
      differentiation have been identified, our complete understanding of this process 
      is lacking. Recent investigations focused on the role of epigenetic regulation in
      lineage-specific differentiation of MSCs have shown that unique patterns of DNA
      methylation and histone modifications play an important role in the induction of 
      MSC differentiation toward specific lineages. Nevertheless, MSC epigenetic
      profiles reflect a more restricted differentiation potential as compared to ES
      cells. Here we review the effect of epigenetic modifications on MSC multipotency 
      and differentiation, with a focus on osteogenic and adipogenic differentiation.
      We also highlight clinical applications of MSC epigenetics and nuclear
      reprogramming.
FAU - Teven, Chad M
AU  - Teven CM
AD  - Molecular Oncology Laboratory, Department of Surgery, The University of Chicago
      Medical Center, 5841 South Maryland Avenue, Chicago, IL 60637, USA.
FAU - Liu, Xing
AU  - Liu X
FAU - Hu, Ning
AU  - Hu N
FAU - Tang, Ni
AU  - Tang N
FAU - Kim, Stephanie H
AU  - Kim SH
FAU - Huang, Enyi
AU  - Huang E
FAU - Yang, Ke
AU  - Yang K
FAU - Li, Mi
AU  - Li M
FAU - Gao, Jian-Li
AU  - Gao JL
FAU - Liu, Hong
AU  - Liu H
FAU - Natale, Ryan B
AU  - Natale RB
FAU - Luther, Gaurav
AU  - Luther G
FAU - Luo, Qing
AU  - Luo Q
FAU - Wang, Linyuan
AU  - Wang L
FAU - Rames, Richard
AU  - Rames R
FAU - Bi, Yang
AU  - Bi Y
FAU - Luo, Jinyong
AU  - Luo J
FAU - Luu, Hue H
AU  - Luu HH
FAU - Haydon, Rex C
AU  - Haydon RC
FAU - Reid, Russell R
AU  - Reid RR
FAU - He, Tong-Chuan
AU  - He TC
LA  - eng
PT  - Journal Article
DEP - 20110711
PL  - United States
TA  - Stem Cells Int
JT  - Stem cells international
JID - 101535822
PMC - PMC3137957
EDAT- 2011/07/21 06:00
MHDA- 2011/07/21 06:01
CRDT- 2011/07/21 06:00
PHST- 2011/03/21 00:00 [received]
PHST- 2011/04/27 00:00 [accepted]
PHST- 2011/07/21 06:00 [entrez]
PHST- 2011/07/21 06:00 [pubmed]
PHST- 2011/07/21 06:01 [medline]
AID - 10.4061/2011/201371 [doi]
PST - ppublish
SO  - Stem Cells Int. 2011;2011:201371. doi: 10.4061/2011/201371. Epub 2011 Jul 11.


PMID- 21772684
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130704
LR  - 20211020
IS  - 2231-2730 (Electronic)
IS  - 0970-9185 (Linking)
VI  - 27
IP  - 2
DP  - 2011 Apr
TI  - Comparison of effects of ketamine, ketamine-dexmedetomidine and
      ketamine-midazolam on dressing changes of burn patients.
PG  - 220-4
LID - 10.4103/0970-9185.81823 [doi]
AB  - OBJECTIVE: The aim of this randomized, controlled study was to compare the
      sedoanalgesic effects of ketamine-dexmedetomidine and ketamine-midazolam on
      dressing changes of burn patients. MATERIALS AND METHODS: Following Ethics
      Committee approval and informed patient consent, 90 ASA physical statuses I and
      II adult burn patients were included in the study. Patients were randomly divided
      into three groups. Ten minutes before dressing change, the dexmedetomidine group 
      (group KD) (n = 30) received a continuous infusion of dexmedetomidine at a rate
      of 1 mug kg(-1), the midazolam group (group KM) (n = 30) received a continuous
      infusion of midazolam at a rate of 0.05 mg kg(-1) and the saline group (group KS)
      (n = 30) received a continuous infusion of saline intravenously. One minute
      before dressing change, each patient was administered 1 mg kg(-1) ketamine
      intravenously. Hemodynamic variables, pain and sedation scores, the number of
      patients requiring additional ketamine, time to dressing change and recovery time
      were recorded. RESULTS: Systolic blood pressure (SBP) values were significantly
      lower at, before and after ketamine administration; and 5, 10 and 15 minutes
      after the procedure in group KD in comparison with the other groups (P <0.05).
      There was no significant difference in pain scores among the groups during the
      study period. Sedation scores were significantly higher in group KD than in
      groups KM and KS at the end of the first hour (P <0.05). Time to dressing change 
      and recovery time were similar in all the groups CONCLUSION: In burn patients
      undergoing dressing changes, although both combinations ketamine-dexmedetomidine 
      and ketamine-midazolam offered an effective sedoanalgesia without causing any
      significant side effect, the former resulted in higher sedation and lower
      hemodynamic discrepancy.
FAU - Gunduz, Murat
AU  - Gunduz M
AD  - Department of Anesthesiology, Cukurova University Faculty of Medicine, Cukurova
      State Hospital, Department of Plastic and Reconstructive Surgery, Adana, Turkey.
FAU - Sakalli, Sefika
AU  - Sakalli S
FAU - Gunes, Yasemin
AU  - Gunes Y
FAU - Kesiktas, Erol
AU  - Kesiktas E
FAU - Ozcengiz, Dilek
AU  - Ozcengiz D
FAU - Isik, Geylan
AU  - Isik G
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Anaesthesiol Clin Pharmacol
JT  - Journal of anaesthesiology, clinical pharmacology
JID - 9516972
PMC - PMC3127303
OTO - NOTNLM
OT  - Burn
OT  - dexmedetomidine
OT  - dressing changes
OT  - ketamine
OT  - midazolam
EDAT- 2011/07/21 06:00
MHDA- 2011/07/21 06:01
CRDT- 2011/07/21 06:00
PHST- 2011/07/21 06:00 [entrez]
PHST- 2011/07/21 06:00 [pubmed]
PHST- 2011/07/21 06:01 [medline]
AID - 10.4103/0970-9185.81823 [doi]
AID - JOACP-27-220 [pii]
PST - ppublish
SO  - J Anaesthesiol Clin Pharmacol. 2011 Apr;27(2):220-4. doi:
      10.4103/0970-9185.81823.


PMID- 21772298
OWN - NLM
STAT- MEDLINE
DCOM- 20110914
LR  - 20211203
IS  - 1532-6535 (Electronic)
IS  - 0009-9236 (Linking)
VI  - 90
IP  - 2
DP  - 2011 Aug
TI  - Ethical considerations regarding disparities pertaining to kidney transplant
      patients.
PG  - 212-4
LID - 10.1038/clpt.2011.73 [doi]
AB  - Racial and ethnic disparities exist throughout the US health-care system,
      including in the field of solid-organ transplant. There are disparities in access
      to health care, health outcomes, and access to transplant centers. Addressing
      this issue requires equity in pretransplant care, increased education and
      referral throughout the transplant process, and research funds targeted to the
      study of problems pertinent to transplantation in certain patient populations.
FAU - Yost, S E
AU  - Yost SE
AD  - Department of Pharmacy, University Medical Center, Tucson, Arizona, USA.
      syost@umcaz.edu
FAU - Srinivas, T
AU  - Srinivas T
FAU - Kaplan, B
AU  - Kaplan B
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Pharmacol Ther
JT  - Clinical pharmacology and therapeutics
JID - 0372741
SB  - IM
MH  - Biomedical Research/economics/methods
MH  - Ethnicity/statistics & numerical data
MH  - Health Services Accessibility/ethics
MH  - Healthcare Disparities/*ethics/ethnology
MH  - Humans
MH  - Kidney Failure, Chronic/ethnology/*surgery
MH  - Kidney Transplantation/*ethics
MH  - Patient Education as Topic/ethics
MH  - Racial Groups/statistics & numerical data
MH  - Referral and Consultation/ethics
MH  - United States
EDAT- 2011/07/21 06:00
MHDA- 2011/09/15 06:00
CRDT- 2011/07/21 06:00
PHST- 2011/07/21 06:00 [entrez]
PHST- 2011/07/21 06:00 [pubmed]
PHST- 2011/09/15 06:00 [medline]
AID - clpt201173 [pii]
AID - 10.1038/clpt.2011.73 [doi]
PST - ppublish
SO  - Clin Pharmacol Ther. 2011 Aug;90(2):212-4. doi: 10.1038/clpt.2011.73.


PMID- 21772037
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20110720
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 8
DP  - 2011 Aug
TI  - 30 years Principles of biomedical ethics: introduction to a symposium on the 6th 
      edition of Tom L Beauchamp and James F Childress' seminal work.
PG  - 454-5
LID - 10.1136/jme.2010.039222 [doi]
FAU - Rauprich, Oliver
AU  - Rauprich O
FAU - Vollmann, Jochen
AU  - Vollmann J
LA  - eng
PT  - Editorial
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
RPI - J Med Ethics. 2011 Oct;37(10):582-3. PMID: 21937466
MH  - Beneficence
MH  - *Bioethics
MH  - Humans
MH  - Professional Autonomy
MH  - Social Justice
EDAT- 2011/07/21 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/07/21 06:00
PHST- 2011/07/21 06:00 [entrez]
PHST- 2011/07/21 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - jme.2010.039222 [pii]
AID - 10.1136/jme.2010.039222 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Aug;37(8):454-5. doi: 10.1136/jme.2010.039222.


PMID- 21771958
OWN - NLM
STAT- MEDLINE
DCOM- 20111109
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 261
IP  - 1
DP  - 2011 Oct
TI  - Nonmasslike enhancement at breast MR imaging: the added value of mammography and 
      US for lesion categorization.
PG  - 69-79
LID - 10.1148/radiol.11110190 [doi]
AB  - PURPOSE: To determine the value of adding conventional imaging (mammography and
      ultrasonography [US]) to nonmasslike enhancement (NMLE) analysis with breast
      magnetic resonance (MR) imaging for predicting malignancy and for building an
      interpretation model incorporating all imaging modalities. MATERIALS AND METHODS:
      The institutional ethics committees approved the study and granted a waiver of
      informed consent. In 115 women (mean age, 48.3 years; range, 21-76 years; 56
      malignant, 12 high-risk, and 63 benign lesions), 131 NMLE lesions were analyzed. 
      Two independent readers first classified MR images by using descriptive Breast
      Imaging Reporting and Data System (BI-RADS) criteria (BI-RADS classification with
      MR images alone [BI-RADS(MR)]) and later repeated this classification, adding
      information from conventional imaging (BI-RADS classification with combination of
      MR images and conventional images [BI-RADS(MR+Con)]). Lesion diagnosis was
      established with surgical histopathologic findings (n = 68), percutaneous biopsy 
      results (n = 25), or 2 years of stability at MR imaging (n = 38). Receiver
      operating characteristic curves were built to compare BI-RADS(MR) with
      BI-RADS(MR+Con). A multivariate interpretation model was constructed and
      validated in a distinct cohort of 44 women. RESULTS: Values for inter- and
      intraobserver agreement, respectively, were better for BI-RADS(MR+Con) (kappa =
      0.847 and 0.937) than for BI-RADS(MR) (kappa = 0.748 and 0.861). For both
      readers, the areas under the receiver operating characteristic curve (AUCs) for
      diagnosis of malignancy were also superior when BI-RADS(MR+Con) (AUC = 0.91
      [reader 1] and 0.93 [reader 2]) was compared with BI-RADS(MR) (AUC = 0.84 [reader
      1] and 0.87 [reader 2]) (P < .05). An interpretation model combining conventional
      imaging with MR imaging criteria showed very good discrimination (AUC = 0.89
      [training set] and 0.90 [validating set]). CONCLUSION: Adding conventional
      imaging to NMLE lesion characterization at breast MR imaging improved the
      diagnostic performance of radiologists, and the interpretation model used offers 
      good accuracy with the potential to optimize the reproducibility of NMLE analysis
      at MR imaging.
CI  - (c) RSNA, 2011.
FAU - Thomassin-Naggara, Isabelle
AU  - Thomassin-Naggara I
AD  - Department of Radiology, Centre de Recherche et d'Investigation des Maladies du
      Sein, Hotel Dieu, Centre Hospitalo-Universitaire de Montreal, Montreal, Canada.
      isabelle.thomassin@tnn.aphp.fr
FAU - Trop, Isabelle
AU  - Trop I
FAU - Chopier, Jocelyne
AU  - Chopier J
FAU - David, Julie
AU  - David J
FAU - Lalonde, Lucie
AU  - Lalonde L
FAU - Darai, Emile
AU  - Darai E
FAU - Rouzier, Roman
AU  - Rouzier R
FAU - Uzan, Serge
AU  - Uzan S
LA  - eng
PT  - Journal Article
DEP - 20110719
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adult
MH  - Aged
MH  - Breast Neoplasms/*diagnosis/diagnostic imaging
MH  - Female
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - *Mammography
MH  - Middle Aged
MH  - Models, Statistical
MH  - Predictive Value of Tests
MH  - Retrospective Studies
MH  - Ultrasonography
MH  - Young Adult
EDAT- 2011/07/21 06:00
MHDA- 2011/11/10 06:00
CRDT- 2011/07/21 06:00
PHST- 2011/07/21 06:00 [entrez]
PHST- 2011/07/21 06:00 [pubmed]
PHST- 2011/11/10 06:00 [medline]
AID - radiol.11110190 [pii]
AID - 10.1148/radiol.11110190 [doi]
PST - ppublish
SO  - Radiology. 2011 Oct;261(1):69-79. doi: 10.1148/radiol.11110190. Epub 2011 Jul 19.


PMID- 21771955
OWN - NLM
STAT- MEDLINE
DCOM- 20111109
LR  - 20191210
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 261
IP  - 1
DP  - 2011 Oct
TI  - Chronic liver disease: systemic and splanchnic venous flow mapping with optimized
      cine phase-contrast MR imaging validated in a phantom model and prospectively
      evaluated in patients.
PG  - 144-55
LID - 10.1148/radiol.11101541 [doi]
AB  - PURPOSE: To validate magnetic resonance (MR) imaging cine phase-contrast blood
      flow mapping in vitro and in patients with chronic liver disease, with or without
      portal hypertension, and to assess the accuracy of azygos, splanchnic, and
      systemic blood flow measured with MR imaging in the detection of high-risk
      esophageal varices and compare these measurements with endoscopic evaluation, the
      reference standard. MATERIALS AND METHODS: The local ethics committee approved
      this study. Patients gave written informed consent. Two phantoms were used to
      validate the MR imaging phase-contrast flow sequence. Patients with liver
      cirrhosis (n = 59), chronic liver disease without cirrhosis (n = 12), and nodular
      regenerative hyperplasia (NRH) (n = 11), and healthy control subjects with no
      liver disease (n = 25) were included. The patients underwent upper digestive
      system endoscopy. Mean abdominal aorta, portal venous, and azygos blood flow was 
      measured on MR images, which were reviewed by two blinded observers to determine 
      the presence and grade of esophageal varices. The reproducibility and intra- and 
      interobserver variability of the blood flow measurements were assessed with
      intraclass correlation coefficients (ICCs). The performance of the MR blood flow 
      measurements in staging high-risk varices was determined with receiver operating 
      characteristic curve analysis. The correlation between MR visual analysis and
      endoscopic grading was assessed by using kappa statistics. RESULTS: MR flow rate 
      measurements had excellent correlations with actual flow values in vitro (ICC >
      0.990 for phantoms 1 and 2). Mean aortic flow was significantly higher in
      patients with cirrhosis than in control subjects (P < .001). Mean azygos flow was
      significantly higher in patients with cirrhosis than in patients with chronic
      liver disease without cirrhosis (P = .005) and control subjects (P < .001). Low
      intra- and interobserver variability (ICC > 0.990 for each blood flow type) and
      high reproducibility (ICC > 0.850 for each blood flow type) were demonstrated.
      The optimal cutoff mean azygos flow value was 2.3 mL/sec for varices with grades 
      of 2 or higher. CONCLUSION: MR imaging azygos flow measurement appears to be a
      promising technique for detecting high-risk esophageal varices in patients with
      portal hypertension.
CI  - (c) RSNA, 2011.
FAU - Gouya, Herve
AU  - Gouya H
AD  - Department of Radiology and Liver Unit and Inserm U-1016, University Paris
      Descartes Paris V, Cochin Hospital, Paris Cedex 14, France. princetgouya@yahoo.fr
FAU - Vignaux, Olivier
AU  - Vignaux O
FAU - Sogni, Philippe
AU  - Sogni P
FAU - Mallet, Vincent
AU  - Mallet V
FAU - Oudjit, Ammar
AU  - Oudjit A
FAU - Pol, Stanislas
AU  - Pol S
FAU - Legmann, Paul
AU  - Legmann P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20110719
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Azygos Vein
MH  - Chronic Disease
MH  - Esophageal and Gastric Varices/*diagnosis/physiopathology
MH  - Female
MH  - Humans
MH  - Liver Diseases/*diagnosis
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Phantoms, Imaging
MH  - Prospective Studies
MH  - Regional Blood Flow
MH  - Splanchnic Circulation
EDAT- 2011/07/21 06:00
MHDA- 2011/11/10 06:00
CRDT- 2011/07/21 06:00
PHST- 2011/07/21 06:00 [entrez]
PHST- 2011/07/21 06:00 [pubmed]
PHST- 2011/11/10 06:00 [medline]
AID - radiol.11101541 [pii]
AID - 10.1148/radiol.11101541 [doi]
PST - ppublish
SO  - Radiology. 2011 Oct;261(1):144-55. doi: 10.1148/radiol.11101541. Epub 2011 Jul
      19.


PMID- 21771952
OWN - NLM
STAT- MEDLINE
DCOM- 20111109
LR  - 20220311
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 261
IP  - 1
DP  - 2011 Oct
TI  - Parkinson disease: diagnostic utility of diffusion kurtosis imaging.
PG  - 210-7
LID - 10.1148/radiol.11102277 [doi]
AB  - PURPOSE: To examine the usefulness of diffusion kurtosis imaging for the
      diagnosis of Parkinson disease (PD). MATERIALS AND METHODS: Examinations were
      performed with the understanding and written consent of each subject, with local 
      ethics committee approval, and in compliance with national legislation and
      Declaration of Helsinki guidelines. Diffusion-weighted magnetic resonance imaging
      was performed in 30 patients with idiopathic PD (mean age, 64.5 years +/- 3.4
      [standard deviation]) and 30 healthy subjects (mean age, 65.0 years +/- 5.1).
      Mean kurtosis, fractional anisotropy, and mean, axial, and radial diffusivity of 
      the basal ganglia were compared between the groups. Disease severity was assessed
      by using Hoehn and Yahr staging and the motor section of the Unified Parkinson's 
      Disease Rating Scale (mean scores, 2.0 and 33.6, respectively). Receiver
      operating characteristic (ROC) analysis was used to compare the diagnostic
      accuracies of the indexes of interest. Pearson correlation coefficient analysis
      was used to correlate imaging findings with disease severity. RESULTS: Mean
      kurtosis in the putamen was higher in the PD group (0.93 +/- 0.15) than in the
      control group (0.71 +/- 0.09) (P < .000416). The area under the ROC curve (AUC)
      was 0.95 for both the ipsilateral putamen and the ipsilateral substantia nigra.
      The mean kurtosis for the ipsilateral substantia nigra had the best diagnostic
      performance (mean cutoff, 1.10; sensitivity, 0.92; specificity, 0.87). In
      contrast, AUCs for the tensor-derived indexes ranged between 0.43 (axial and
      radial diffusivity in substantia nigra) and 0.65 (fractional anisotropy in
      substantia nigra). CONCLUSION: Diffusion kurtosis imaging in the basal ganglia,
      as compared with conventional diffusion-tensor imaging, can improve the diagnosis
      of PD.
CI  - (c) RSNA, 2011.
FAU - Wang, Jiun-Jie
AU  - Wang JJ
AD  - Department of Medical Imaging and Intervention and Neurology, and Neuroscience
      Research Center, Chang-Gung Memorial Hospital LinKou Medical Center, Taiwan,
      Republic of China.
FAU - Lin, Wey-Yil
AU  - Lin WY
FAU - Lu, Chin-Song
AU  - Lu CS
FAU - Weng, Yi-Hsin
AU  - Weng YH
FAU - Ng, Shu-Hang
AU  - Ng SH
FAU - Wang, Chi-Hong
AU  - Wang CH
FAU - Liu, Hao-Li
AU  - Liu HL
FAU - Hsieh, Ren-Hsiang
AU  - Hsieh RH
FAU - Wan, Yung-Liang
AU  - Wan YL
FAU - Wai, Yau-Yau
AU  - Wai YY
LA  - eng
PT  - Journal Article
DEP - 20110719
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
CIN - Radiology. 2012 Nov;265(2):645-6; author reply 646-7. PMID: 23093710
MH  - Aged
MH  - Basal Ganglia/pathology
MH  - *Diffusion Magnetic Resonance Imaging
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Parkinson Disease/*diagnosis
MH  - Prospective Studies
EDAT- 2011/07/21 06:00
MHDA- 2011/11/10 06:00
CRDT- 2011/07/21 06:00
PHST- 2011/07/21 06:00 [entrez]
PHST- 2011/07/21 06:00 [pubmed]
PHST- 2011/11/10 06:00 [medline]
AID - radiol.11102277 [pii]
AID - 10.1148/radiol.11102277 [doi]
PST - ppublish
SO  - Radiology. 2011 Oct;261(1):210-7. doi: 10.1148/radiol.11102277. Epub 2011 Jul 19.


PMID- 21771936
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20120227
IS  - 1943-5657 (Electronic)
IS  - 0033-8397 (Linking)
VI  - 82
IP  - 6
DP  - 2011 Jul-Aug
TI  - A review of ethics for the radiologic technologist.
PG  - 519-36
AB  - Radiologic technology students learn ethical theory, ethical principles and the
      Code of Ethics. However, over time, the concepts may fade from the radiologic
      technologist's memory. Periodic review of the ethical concepts and the American
      Registry of Radiologic Technologists Standards of Ethics are important to
      maintain a clear understanding of ethical expectations of the radiologic
      technologist. This article provides examples of potential ethical violations to
      illustrate each principle in the Code of Ethics and each tenet in the Rules of
      Ethics. The examples are intended to help readers think about and relate to
      situations they may encounter. This article is a Directed Reading. Your access to
      Directed Reading quizzes for continuing education credit is determined by your CE
      preference. For access to other quizzes, go to www.asrt.org/store.
FAU - Reed, Joan R
AU  - Reed JR
AD  - St Catherine University in St Paul, Minnesota, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Radiol Technol
JT  - Radiologic technology
JID - 0401256
SB  - IM
EIN - Radiol Technol. 2011 Sep-Oct;83(1):56
EIN - Radiol Technol. 2012 Jan;83(3):253
MH  - *Ethics, Professional
MH  - Humans
MH  - Technology, Radiologic/*ethics
EDAT- 2011/07/21 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/21 06:00
PHST- 2011/07/21 06:00 [entrez]
PHST- 2011/07/21 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 82/6/519 [pii]
PST - ppublish
SO  - Radiol Technol. 2011 Jul-Aug;82(6):519-36.


PMID- 21771835
OWN - NLM
STAT- MEDLINE
DCOM- 20120227
LR  - 20181023
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 343
DP  - 2011 Jul 19
TI  - Include medical ethics in the Research Excellence Framework.
PG  - d3968
LID - 10.1136/bmj.d3968 [doi]
LID - bmj.d3968 [pii]
FAU - Kong, Wing May
AU  - Kong WM
FAU - Vernon, Bryan
AU  - Vernon B
FAU - Boyd, Kenneth
AU  - Boyd K
FAU - Gillon, Raanan
AU  - Gillon R
FAU - Farsides, Bobbie
AU  - Farsides B
FAU - Stirrat, Gordon
AU  - Stirrat G
LA  - eng
PT  - Letter
DEP - 20110719
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
SB  - IM
MH  - *Empirical Research
MH  - *Ethics, Medical
MH  - Ethics, Research
EDAT- 2011/07/21 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/07/21 06:00
PHST- 2011/07/21 06:00 [entrez]
PHST- 2011/07/21 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - 10.1136/bmj.d3968 [doi]
PST - epublish
SO  - BMJ. 2011 Jul 19;343:d3968. doi: 10.1136/bmj.d3968.


PMID- 21771778
OWN - NLM
STAT- MEDLINE
DCOM- 20120315
LR  - 20220408
IS  - 1471-8391 (Electronic)
IS  - 0007-1420 (Linking)
VI  - 100
DP  - 2011
TI  - Cell-based therapeutics for liver disorders.
PG  - 157-72
LID - 10.1093/bmb/ldr031 [doi]
AB  - INTRODUCTION: Due to a lack of adequate liver donors and post-surgical
      complications, researchers propose that cell therapy should be an alternative
      treatment for patients with end-stage liver diseases. DATA SOURCES: We performed 
      a literature review on cell-based therapy for liver disorders. AREAS OF
      AGREEMENT: Due to growing numbers of patients on waiting lists for liver
      transplantation, a substitute treatment strategy is needed for our patients. Cell
      therapy can save patients who are in life-threatening situations, enabling them
      to have more time and increase their chances of survival. Pluripotent stem cells 
      can be a good resource for cell-based therapy after the establishment of
      efficient differentiation protocols in addition to the settlement of ethical and 
      immunological issues. Cell-based therapy will be applicable after the approval of
      its efficiency via animal model studies. AREAS OF CONTROVERSY: Transplanted cells
      cannot integrate into the recipient liver and lose their functionality after a
      limited time. The rate of homing and transdifferentiation of transplanted cells
      into hepatocytes is scant. GROWING POINTS: Application of autologous bone marrow 
      mononuclear cells (MNCs), hematopoietic and mesenchymal stem cells (HSCs and
      MSCs) has improved the general conditions of certain patients. Although this
      improvement is temporary, new studies have focused on increasing their
      performance. TIMELY AREAS FOR DEVELOPING RESEARCH: The safety, feasibility and
      efficacy of applying MNCs, HSCs and MSCs in liver disorders have been proven in
      clinical trials. Patient-specific cell therapy after the production of induced
      pluripotent stem cells and new discoveries in somatic cell conversion during
      transdifferentiation are promising insights.
FAU - Vosough, Massoud
AU  - Vosough M
AD  - Department of Stem Cells and Developmental Biology, Cell Science Research Center,
      Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
FAU - Moslem, Mohsen
AU  - Moslem M
FAU - Pournasr, Behshad
AU  - Pournasr B
FAU - Baharvand, Hossein
AU  - Baharvand H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110719
PL  - England
TA  - Br Med Bull
JT  - British medical bulletin
JID - 0376542
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - Humans
MH  - Liver Diseases/etiology/physiopathology/*therapy
MH  - Liver Regeneration/physiology
MH  - Liver, Artificial
MH  - Stem Cell Transplantation/*methods
MH  - Tissue Engineering/methods
EDAT- 2011/07/21 06:00
MHDA- 2012/03/16 06:00
CRDT- 2011/07/21 06:00
PHST- 2011/07/21 06:00 [entrez]
PHST- 2011/07/21 06:00 [pubmed]
PHST- 2012/03/16 06:00 [medline]
AID - ldr031 [pii]
AID - 10.1093/bmb/ldr031 [doi]
PST - ppublish
SO  - Br Med Bull. 2011;100:157-72. doi: 10.1093/bmb/ldr031. Epub 2011 Jul 19.


PMID- 21771646
OWN - NLM
STAT- MEDLINE
DCOM- 20111227
LR  - 20220321
IS  - 1873-3476 (Electronic)
IS  - 0378-5173 (Linking)
VI  - 416
IP  - 1
DP  - 2011 Sep 15
TI  - Development of a serum-free human cornea construct for in vitro drug absorption
      studies: the influence of varying cultivation parameters on barrier
      characteristics.
PG  - 268-79
LID - 10.1016/j.ijpharm.2011.07.004 [doi]
AB  - The increased use of ophthalmic products in recent years has led to an increased 
      demand for in vitro and in vivo transcorneal drug absorption studies.
      Cell-culture models of the human cornea can avoid several of the disadvantages of
      widely used animal experimental models, including ethical concerns and poor
      standardisation. This study describes the development of a serum-free cultivated,
      three-dimensional human cornea model (Hemicornea, HC) for drug absorption
      experiments. The impact of varying cultivation conditions on the corneal barrier 
      function was analysed and compared with excised rabbit and porcine corneas. The
      HC was cultivated on permeable polycarbonate filters using immortalised human
      keratocytes and a corneal epithelial cell line. The equivalence to native tissue 
      was investigated through absorption studies using model substances with a wide
      range of molecular characteristics, including hydrophilic sodium fluorescein,
      lipophilic rhodamine B and fluorescein isothiocyanate (FITC)-labelled
      macromolecule dextran. To study the intra-laboratory repeatability and construct 
      cultivation, the permeation studies were performed independently by different
      researchers. The HC exhibited a permeation barrier in the same range as excised
      animal corneas, high reproducibility and a lower standard deviation. Therefore,
      the HC could be a promising in vitro alternative to ex vivo corneal tissues in
      preclinical permeation studies.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Hahne, Matthias
AU  - Hahne M
AD  - Institut fur Pharmazeutische Technologie, Technische Universitat Braunschweig,
      Braunschweig, Germany.
FAU - Reichl, Stephan
AU  - Reichl S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110713
PL  - Netherlands
TA  - Int J Pharm
JT  - International journal of pharmaceutics
JID - 7804127
RN  - 0 (Culture Media)
RN  - 0 (Ophthalmic Solutions)
SB  - IM
MH  - Absorption
MH  - Animals
MH  - Cell Culture Techniques/*methods
MH  - Cell Line, Transformed
MH  - Culture Media
MH  - Electric Impedance
MH  - Epithelium, Corneal/anatomy & histology/*metabolism
MH  - Humans
MH  - Molecular Imaging/methods
MH  - Ophthalmic Solutions/*pharmacokinetics
MH  - Rabbits
MH  - Reproducibility of Results
MH  - Serum
MH  - Swine
EDAT- 2011/07/21 06:00
MHDA- 2011/12/28 06:00
CRDT- 2011/07/21 06:00
PHST- 2011/04/29 00:00 [received]
PHST- 2011/07/01 00:00 [revised]
PHST- 2011/07/04 00:00 [accepted]
PHST- 2011/07/21 06:00 [entrez]
PHST- 2011/07/21 06:00 [pubmed]
PHST- 2011/12/28 06:00 [medline]
AID - S0378-5173(11)00633-8 [pii]
AID - 10.1016/j.ijpharm.2011.07.004 [doi]
PST - ppublish
SO  - Int J Pharm. 2011 Sep 15;416(1):268-79. doi: 10.1016/j.ijpharm.2011.07.004. Epub 
      2011 Jul 13.


PMID- 21771309
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20211020
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 12
DP  - 2011 Jul 19
TI  - Qualitative thematic analysis of consent forms used in cancer genome sequencing.
PG  - 14
LID - 10.1186/1472-6939-12-14 [doi]
AB  - BACKGROUND: Large-scale whole genome sequencing (WGS) studies promise to
      revolutionize cancer research by identifying targets for therapy and by
      discovering molecular biomarkers to aid early diagnosis, to better determine
      prognosis and to improve treatment response prediction. Such projects raise a
      number of ethical, legal, and social (ELS) issues that should be considered. In
      this study, we set out to discover how these issues are being handled across
      different jurisdictions. METHODS: We examined informed consent (IC) forms from 30
      cancer genome sequencing studies to assess (1) stated purpose of sample
      collection, (2) scope of consent requested, (3) data sharing protocols (4)
      privacy protection measures, (5) described risks of participation, (6) subject
      re-contacting, and (7) protocol for withdrawal. RESULTS: There is a high degree
      of similarity in how cancer researchers engaged in WGS are protecting participant
      privacy. We observed a strong trend towards both using samples for additional,
      unspecified research and sharing data with other investigators. IC forms were
      varied in terms of how they discussed re-contacting participants, returning
      results and facilitating participant withdrawal. Contrary to expectation, there
      were no consistent trends that emerged over the eight year period from which
      forms were collected. CONCLUSION: Examining IC forms from WGS studies elucidates 
      how investigators are handling ELS challenges posed by this research. This
      information is important for ensuring that while the public benefits of research 
      are maximized, the rights of participants are also being appropriately respected.
FAU - Allen, Clarissa
AU  - Allen C
AD  - Program in Cancer Genetics, Department of Oncology, McGill University, Montreal, 
      Quebec, Canada.
FAU - Foulkes, William D
AU  - Foulkes WD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110719
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Australia
MH  - Belgium
MH  - Canada
MH  - Consent Forms/ethics/*standards
MH  - Ethics Committees, Research
MH  - Genetic Testing/*ethics
MH  - Genome, Human
MH  - Humans
MH  - Informed Consent/*ethics/standards
MH  - Neoplasms/diagnosis/drug therapy/*genetics
MH  - Netherlands
MH  - Qualitative Research
MH  - Research Design
MH  - United Kingdom
MH  - United States
PMC - PMC3170865
EDAT- 2011/07/21 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/07/21 06:00
PHST- 2011/03/30 00:00 [received]
PHST- 2011/07/19 00:00 [accepted]
PHST- 2011/07/21 06:00 [entrez]
PHST- 2011/07/21 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - 1472-6939-12-14 [pii]
AID - 10.1186/1472-6939-12-14 [doi]
PST - epublish
SO  - BMC Med Ethics. 2011 Jul 19;12:14. doi: 10.1186/1472-6939-12-14.


PMID- 21771227
OWN - NLM
STAT- MEDLINE
DCOM- 20140403
LR  - 20211020
IS  - 1369-7625 (Electronic)
IS  - 1369-6513 (Linking)
VI  - 16
IP  - 3
DP  - 2013 Sep
TI  - Financial incentives to encourage healthy behaviour: an analysis of U.K. media
      coverage.
PG  - 292-304
LID - 10.1111/j.1369-7625.2011.00719.x [doi]
AB  - BACKGROUND: Policies to use financial incentives to encourage healthy behaviour
      are controversial. Much of this controversy is played out in the mass media, both
      reflecting and shaping public opinion. OBJECTIVE: To describe U.K. mass media
      coverage of incentive schemes, comparing schemes targeted at different client
      groups and assessing the relative prominence of the views of different interest
      groups. DESIGN: Thematic content analysis. SUBJECTS: National and local news
      coverage in newspapers, news media targeted at health-care providers and popular 
      websites between January 2005 and February 2010. SETTING: U.K. mass media.
      RESULTS: The study included 210 articles. Fifteen separate arguments favourable
      towards schemes, and 19 unfavourable, were identified. Overall, coverage was more
      favourable than unfavourable, although most articles reported a mix of views.
      Arguments about the prevalence and seriousness of the health problems targeted by
      incentive schemes were uncontested. Moral and ethical objections to such schemes 
      were common, focused in particular on recipients such as drug users or the
      overweight who were already stereotyped as morally deficient, and these arguments
      were largely uncontested. Arguments about the effectiveness of schemes and their 
      potential for benefit or harm were areas of greater contestation. Government,
      public health and other health-care provider interests dominated favourable
      coverage; opposition came from rival politicians, taxpayers' representatives,
      certain charities and from some journalists themselves. CONCLUSIONS: Those
      promoting incentive schemes for people who might be regarded as 'undeserving'
      should plan a media strategy that anticipates their public reception.
CI  - (c) 2011 John Wiley & Sons Ltd.
FAU - Parke, Hannah
AU  - Parke H
AD  - Barts and the London School of Medicine and Dentistry, Queen Mary University of
      London, London, UK. c.seale@qmul.ac.uk
FAU - Ashcroft, Richard
AU  - Ashcroft R
FAU - Brown, Rebecca
AU  - Brown R
FAU - Marteau, Theresa M
AU  - Marteau TM
FAU - Seale, Clive
AU  - Seale C
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - 086031/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110720
PL  - England
TA  - Health Expect
JT  - Health expectations : an international journal of public participation in health 
      care and health policy
JID - 9815926
SB  - IM
MH  - *Health Behavior
MH  - Health Promotion/economics/ethics/methods
MH  - Humans
MH  - *Mass Media/statistics & numerical data
MH  - *Motivation
MH  - Program Evaluation
MH  - United Kingdom
PMC - PMC4180042
MID - EMS60415
OID - NLM: EMS60415
OTO - NOTNLM
OT  - conditional cash transfer
OT  - health incentives
OT  - mass media
OT  - public opinion
OT  - public response
EDAT- 2011/07/21 06:00
MHDA- 2014/04/04 06:00
CRDT- 2011/07/21 06:00
PHST- 2011/07/21 06:00 [entrez]
PHST- 2011/07/21 06:00 [pubmed]
PHST- 2014/04/04 06:00 [medline]
AID - 10.1111/j.1369-7625.2011.00719.x [doi]
PST - ppublish
SO  - Health Expect. 2013 Sep;16(3):292-304. doi: 10.1111/j.1369-7625.2011.00719.x.
      Epub 2011 Jul 20.


PMID- 21771204
OWN - NLM
STAT- MEDLINE
DCOM- 20120406
LR  - 20211203
IS  - 1468-1331 (Electronic)
IS  - 1351-5101 (Linking)
VI  - 19
IP  - 1
DP  - 2012 Jan
TI  - What is the expert's option on antiplatelet therapy in moyamoya disease? Results 
      of a worldwide Survey.
PG  - 163-7
LID - 10.1111/j.1468-1331.2011.03481.x [doi]
AB  - BACKGROUND AND PURPOSE: Moyamoya disease (MMD) is a rare idiopathic vasculopathy 
      characterized by an extensive network of fine collaterals in the setting of
      bilateral progressive stenosis and finally occlusion of the intracranial portion 
      of the internal carotid artery and proximal anterior and medial arteries of
      Circle of Willis. Owing to the rarity of the disease and ethical concerns,
      double-blinded, randomized controlled trials about treatment options are
      completely lacking. The appropriate conservative treatment instead, before or
      after revascularization surgery, is nearly completely neglected in scientific
      literature, even in Asia. METHODS: We developed a questionnaire with response
      options offered in the multiple choice method. The survey was sent with the
      request to reply within September 2010 to January 2011 by email to experts in the
      treatment of MMD. As an international expert, authors were selected who had
      written more than one scientific article or book chapter on the subject. We took 
      special care not to select only Asian scientists, but also considered experts on 
      the disease in Caucasian patients. RESULTS: Among the 77 physicians surveyed, 32 
      (41.55%) responded. Twenty-one (65.6%) Asian experts and 11 (34.4%) non-Asian
      experts participated in this survey. The majority of experts thought that
      long-term antiplatelet therapy is not essential in the treatment of MMD. Ten of
      32 (31%) participants agreed to long-term antiplatelet treatment with
      acetylsalicylic acid 100 mg/day. There was a significant difference in answers
      between Asian and non-Asian experts (P = 0.0128). CONCLUSION: It is interesting
      that the majority of Non-Asian respondents recommend antiplatelet drugs, while
      this is an unusual approach in MMD of the Asian experts. Perhaps, this
      significant difference is well founded by the different experiences of the
      experts related to the difference in disease presentation between Asians and
      Caucasians. The role of conservative and surgical treatment in MMD needs further 
      evaluation with larger cohorts and a focus on long-term clinical outcome.
CI  - (c) 2011 The Author(s). European Journal of Neurology (c) 2011 EFNS.
FAU - Kraemer, M
AU  - Kraemer M
AD  - Department of Neurology, Alfried-Krupp-Hospital, Essen, Germany.
      markus.kraemer@krupp-krankenhaus.de
FAU - Berlit, P
AU  - Berlit P
FAU - Diesner, F
AU  - Diesner F
FAU - Khan, N
AU  - Khan N
LA  - eng
PT  - Journal Article
DEP - 20110720
PL  - England
TA  - Eur J Neurol
JT  - European journal of neurology
JID - 9506311
RN  - 0 (Platelet Aggregation Inhibitors)
SB  - IM
MH  - Asians
MH  - Data Collection
MH  - *Expert Testimony
MH  - Humans
MH  - Moyamoya Disease/*drug therapy
MH  - Platelet Aggregation Inhibitors/*therapeutic use
MH  - Practice Patterns, Physicians'/*statistics & numerical data
MH  - Whites
EDAT- 2011/07/21 06:00
MHDA- 2012/04/07 06:00
CRDT- 2011/07/21 06:00
PHST- 2011/07/21 06:00 [entrez]
PHST- 2011/07/21 06:00 [pubmed]
PHST- 2012/04/07 06:00 [medline]
AID - 10.1111/j.1468-1331.2011.03481.x [doi]
PST - ppublish
SO  - Eur J Neurol. 2012 Jan;19(1):163-7. doi: 10.1111/j.1468-1331.2011.03481.x. Epub
      2011 Jul 20.


PMID- 21771188
OWN - NLM
STAT- MEDLINE
DCOM- 20111209
LR  - 20220111
IS  - 1747-4477 (Electronic)
IS  - 1329-1947 (Linking)
VI  - 37
IP  - 2
DP  - 2011 Aug
TI  - Endoscopic removal of an endodontic file accidentally swallowed: clinical and
      legal approaches.
PG  - 76-8
LID - 10.1111/j.1747-4477.2009.00220.x [doi]
AB  - The use of a rubber dam is an essential procedure when treating root canals, and 
      not using it may compromise the success of the treatment, as well as the
      patient's health. This report presents a case in which a K-file was accidentally 
      swallowed during an endodontic procedure, performed without the use of a rubber
      dam. Given the absence of immediate clinical complications, the subject underwent
      a chest radiograph. The file was located at the oesophagogastric junction and was
      later removed by endoscopy. In addition to the clinical repercussions, this
      example also illustrates the ethical-legal aspects of this type of accident.
CI  - (c) 2009 The Authors. Australian Endodontic Journal (c) 2009 Australian Society
      of Endodontology.
FAU - Silva, Rhonan F
AU  - Silva RF
AD  - Department of Legal Dentistry/Morphology, Piracicaba Dental School, Campinas
      State University, Piracicaba, Sao Paulo, Brazil. rhonanfs@terra.com.br
FAU - Martins, Emerson C
AU  - Martins EC
FAU - Prado, Felippe B
AU  - Prado FB
FAU - Junior, Jacy R C
AU  - Junior JR
FAU - Junior, Eduardo D
AU  - Junior ED
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20091215
PL  - Australia
TA  - Aust Endod J
JT  - Australian endodontic journal : the journal of the Australian Society of
      Endodontology Inc
JID - 100888004
MH  - Adult
MH  - Deglutition/physiology
MH  - *Esophagogastric Junction
MH  - Esophagoscopy/*methods
MH  - Foreign Bodies/*therapy
MH  - Humans
MH  - Male
MH  - Patient Safety/legislation & jurisprudence
MH  - Root Canal Preparation/*instrumentation
MH  - Rubber Dams
EDAT- 2011/07/21 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/07/21 06:00
PHST- 2011/07/21 06:00 [entrez]
PHST- 2011/07/21 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 10.1111/j.1747-4477.2009.00220.x [doi]
PST - ppublish
SO  - Aust Endod J. 2011 Aug;37(2):76-8. doi: 10.1111/j.1747-4477.2009.00220.x. Epub
      2009 Dec 15.


PMID- 21770962
OWN - NLM
STAT- MEDLINE
DCOM- 20111212
LR  - 20151119
IS  - 1440-1630 (Electronic)
IS  - 0045-0766 (Linking)
VI  - 58
IP  - 4
DP  - 2011 Aug
TI  - 'Le moment de la lune'. an auto-ethnographic tale of practice about menarche in a
      children's hospital.
PG  - 270-5
LID - 10.1111/j.1440-1630.2011.00929.x [doi]
AB  - INTRODUCTION: Auto-ethnographic accounts can highlight unsaid moments of
      professional practice. In this case, my auto-ethnographic tale 'Le moment de la
      lune' re-inscribes subjugated knowledge about menstruation and occupational
      therapy practice in the era before adolescent wards. METHODS: This fictional tale
      is written in direct dialogue with an article that was published in this journal 
      at a particular point in my own career as an occupational therapist. In the tale 
      I am 'writing in' what was not written about in my article and in occupational
      therapy generally. This 'writing-in'/re-inscribing is the research method.
      FINDINGS: My previous article 'Normal spaces' published in this journal in 1985, 
      was organised around principles and generalities of youth-specific practice. The 
      original article had little locating the personal or evoking the body and a heavy
      reliance on the literature. Issues of gender and culture were largely absent, or,
      perhaps, 'written out'. The corresponding tale of embodied sexuality, 'Le moment 
      de la lune', articulates something of local complex practice and the
      particularity of individual therapeutic work to do with menstruation in
      self-care. DISCUSSION: Points of tension in 'Normal spaces' are elaborated and I 
      explain how 'Le moment de la lune' problematises supporting menarche in a
      children's hospital. Now practice has moved on with dedicated adolescent wards in
      all major children's hospitals. Nevertheless, occupational therapy practice
      around issues of menstrual self-management is still under-documented. Writing
      about unspoken moments of practice can have ethical implications for expanding
      the ways occupational therapy practice can be written and understood.
CI  - (c) 2011 The Author. Australian Occupational Therapy Journal (c) 2011
      Occupational Therapy Australia.
FAU - Denshire, Sally
AU  - Denshire S
AD  - Faculty of Arts and Social Sciences, Centre for Research in Learning and Change, 
      University of Technology, Sydney, New South Wales, Australia.
      sdenshire@csu.edu.au
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110512
PL  - Australia
TA  - Aust Occup Ther J
JT  - Australian occupational therapy journal
JID - 15420200R
SB  - IM
MH  - Anthropology, Cultural
MH  - Attitude of Health Personnel
MH  - Culture
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - *Hospitals, Pediatric
MH  - Humans
MH  - Menarche/*psychology
MH  - *Narration
MH  - Occupational Therapy/*psychology
MH  - *Practice Patterns, Physicians'
MH  - Professional-Patient Relations
MH  - Qualitative Research
MH  - Women's Health
MH  - *Writing
EDAT- 2011/07/21 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/07/21 06:00
PHST- 2011/07/21 06:00 [entrez]
PHST- 2011/07/21 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 10.1111/j.1440-1630.2011.00929.x [doi]
PST - ppublish
SO  - Aust Occup Ther J. 2011 Aug;58(4):270-5. doi: 10.1111/j.1440-1630.2011.00929.x.
      Epub 2011 May 12.


PMID- 21770961
OWN - NLM
STAT- MEDLINE
DCOM- 20111212
LR  - 20151119
IS  - 1440-1630 (Electronic)
IS  - 0045-0766 (Linking)
VI  - 58
IP  - 4
DP  - 2011 Aug
TI  - Maintenance of professional currency: perceptions of occupational therapists.
PG  - 261-9
LID - 10.1111/j.1440-1630.2011.00927.x [doi]
AB  - BACKGROUND/AIM: In common with other health professionals, occupational
      therapists have a growing ethical and legal obligation to maintain competence and
      currency in their area of practice. Despite this context of increasing demands
      for professional accountability, there is little known about how occupational
      therapists perceive the role and meaning of professional currency in their
      day-to-day practice. This qualitative study sought to explore this further.
      METHODS: Four focus group interviews were conducted, with 17 South Australian
      occupational therapists. Participants worked in a variety of practice areas. They
      covered both metropolitan and rural settings and ranged from being recent
      graduates to experienced therapists. The interviews involved facilitating small
      group discussion around a series of open-ended semi-structured questions. The
      resulting discussions were recorded and transcribed. Thematic analysis was
      utilised to explore participants' perspectives. RESULTS: Thematic analysis of the
      transcripts revealed five themes. These included: self-determination; perceived
      capacity; workplace impact; you need to have people around; and looking after
      yourself. These themes were conceptualised as incorporating dynamic foundational 
      and constructional aspects. Foundational aspects facilitate or hinder the pursuit
      of professional currency, and constructional aspects encompass the meaning and
      value ascribed to professional currency. CONCLUSION: These findings yield some
      interesting insights into the way therapists think about and structure their
      professional learning, and provide direction to plan professional development
      activities based on self-identified need and preference.
CI  - (c) 2011 The Authors. Australian Occupational Therapy Journal (c) 2011
      Occupational Therapy Australia.
FAU - Murray, Carolyn
AU  - Murray C
AD  - School of Health Sciences, University of South Australia, Adelaide, SA 5001,
      Australia. carolyn.murray@unisa.edu.au
FAU - Lawry, Jan
AU  - Lawry J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110403
PL  - Australia
TA  - Aust Occup Ther J
JT  - Australian occupational therapy journal
JID - 15420200R
SB  - IM
MH  - Focus Groups
MH  - Humans
MH  - Interpersonal Relations
MH  - Job Satisfaction
MH  - Occupational Therapy/*psychology
MH  - *Practice Patterns, Physicians'
MH  - *Professional Competence
MH  - *Professional Role
MH  - Qualitative Research
MH  - *Social Perception
MH  - *Staff Development
MH  - Workload
EDAT- 2011/07/21 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/07/21 06:00
PHST- 2011/07/21 06:00 [entrez]
PHST- 2011/07/21 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 10.1111/j.1440-1630.2011.00927.x [doi]
PST - ppublish
SO  - Aust Occup Ther J. 2011 Aug;58(4):261-9. doi: 10.1111/j.1440-1630.2011.00927.x.
      Epub 2011 Apr 3.


PMID- 21770896
OWN - NLM
STAT- MEDLINE
DCOM- 20120325
LR  - 20151119
IS  - 1399-6576 (Electronic)
IS  - 0001-5172 (Linking)
VI  - 55
IP  - 8
DP  - 2011 Sep
TI  - Increased lung clearance of isoflurane shortens emergence in obesity: a
      prospective randomized-controlled trial.
PG  - 995-1001
LID - 10.1111/j.1399-6576.2011.02486.x [doi]
AB  - BACKGROUND: There is a concern that obesity may play a role in prolonging
      emergence from fat-soluble inhalational anaesthetics. We hypothesized that
      increased pulmonary clearance of isoflurane will shorten immediate recovery from 
      anaesthesia and post-anaesthesia care unit (PACU) stay in obese patients.
      METHODS: After Ethics Review Board approval, 44 ASA I-III patients with BMI>30
      kg/m(2) undergoing elective gynaecological or urological surgery were randomized 
      after completion of surgery to either an isocapnic hyperpnoea (IH) or a
      conventional recovery (C) group. The anaesthesia protocol included propofol,
      fentanyl, morphine, rocuronium and isoflurane in air/O(2) . Groups were compared 
      using unpaired t-test and ANOVA. RESULTS: Minute ventilation in the IH group
      before extubation was 22.6 +/- 2.7 vs. 6.3 +/- 1.8 l/min in the C group. Compared
      with C, the IH group had a shorter time to extubation (5.4 +/- 2.7 vs. 15.8 +/-
      2.7 min, P<0.01), initiation of spontaneous ventilation (2.7 +/- 2.3 vs. 6.5 +/- 
      4.5 min, P<0.01), BIS recovery >75 (3.2 +/- 2.3 vs. 8.9 +/- 5.8 min, P<0.01), eye
      opening (4.6 +/- 2.9 vs. 13.6 +/- 7.1 min, P<0.01) and eligibility for leaving
      the operating room (7.1 +/- 2.9 vs. 19.9 +/- 11.9 min, P<0.01). There was no
      difference in time for eligibility for PACU discharge. CONCLUSION: Increasing
      alveolar ventilation enhances anaesthetic elimination and accelerates short-term 
      recovery in obese patients.
CI  - (c) 2011 The Authors. Acta Anaesthesiologica Scandinavica (c) 2011 The Acta
      Anaesthesiologica Scandinavica Foundation.
FAU - Katznelson, R
AU  - Katznelson R
AD  - Department of Anesthesia and Pain Management, University Health Network, Toronto 
      General Hospital, ON, Canada. rita.katznelson@uhn.on.ca
FAU - Naughton, F
AU  - Naughton F
FAU - Friedman, Z
AU  - Friedman Z
FAU - Lei, D
AU  - Lei D
FAU - Duffin, J
AU  - Duffin J
FAU - Fedorko, L
AU  - Fedorko L
FAU - Wasowicz, M
AU  - Wasowicz M
FAU - Van Rensburg, A
AU  - Van Rensburg A
FAU - Murphy, J
AU  - Murphy J
FAU - Fisher, J A
AU  - Fisher JA
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110720
PL  - England
TA  - Acta Anaesthesiol Scand
JT  - Acta anaesthesiologica Scandinavica
JID - 0370270
RN  - 0 (Anesthetics, Inhalation)
RN  - CYS9AKD70P (Isoflurane)
SB  - IM
MH  - Aged
MH  - Airway Management
MH  - *Anesthesia Recovery Period
MH  - Anesthesia, General
MH  - *Anesthesia, Inhalation
MH  - Anesthetics, Inhalation/*pharmacokinetics
MH  - Critical Care
MH  - Endpoint Determination
MH  - Female
MH  - Gynecologic Surgical Procedures
MH  - Humans
MH  - Isoflurane/*pharmacokinetics
MH  - Lung/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Obesity/complications/*physiopathology
MH  - Postoperative Complications/epidemiology
MH  - Postoperative Nausea and Vomiting/epidemiology
MH  - Posture
MH  - Prospective Studies
EDAT- 2011/07/21 06:00
MHDA- 2012/03/27 06:00
CRDT- 2011/07/21 06:00
PHST- 2011/07/21 06:00 [entrez]
PHST- 2011/07/21 06:00 [pubmed]
PHST- 2012/03/27 06:00 [medline]
AID - 10.1111/j.1399-6576.2011.02486.x [doi]
PST - ppublish
SO  - Acta Anaesthesiol Scand. 2011 Sep;55(8):995-1001. doi:
      10.1111/j.1399-6576.2011.02486.x. Epub 2011 Jul 20.


PMID- 21770876
OWN - NLM
STAT- MEDLINE
DCOM- 20110921
LR  - 20201230
IS  - 1326-5377 (Electronic)
IS  - 0025-729X (Linking)
VI  - 195
IP  - 2
DP  - 2011 Jul 18
TI  - Is it ethical for medical practitioners to prescribe alternative and
      complementary treatments that may lack an evidence base? - No.
PG  - 79
FAU - Dwyer, John M
AU  - Dwyer JM
AD  - University of New South Wales, Sydney, NSW, Australia. j.dwyer@unsw.edu.au
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - Australia
TA  - Med J Aust
JT  - The Medical journal of Australia
JID - 0400714
SB  - IM
CON - Med J Aust. 2011 Jul 18;195(2):78. PMID: 21770875
CIN - Med J Aust. 2011 Dec 19;195(11-12):660-1. PMID: 22171856
MH  - Complementary Therapies/*ethics
MH  - Evidence-Based Medicine/*ethics
MH  - General Practitioners/ethics
MH  - Humans
MH  - Treatment Outcome
EDAT- 2011/07/21 06:00
MHDA- 2011/09/22 06:00
CRDT- 2011/07/21 06:00
PHST- 2011/05/22 00:00 [received]
PHST- 2011/05/27 00:00 [accepted]
PHST- 2011/07/21 06:00 [entrez]
PHST- 2011/07/21 06:00 [pubmed]
PHST- 2011/09/22 06:00 [medline]
AID - dwy10610_fm [pii]
AID - 10.5694/j.1326-5377.2011.tb03212.x [doi]
PST - ppublish
SO  - Med J Aust. 2011 Jul 18;195(2):79. doi: 10.5694/j.1326-5377.2011.tb03212.x.


PMID- 21770875
OWN - NLM
STAT- MEDLINE
DCOM- 20110921
LR  - 20201230
IS  - 1326-5377 (Electronic)
IS  - 0025-729X (Linking)
VI  - 195
IP  - 2
DP  - 2011 Jul 18
TI  - Is it ethical for medical practitioners to prescribe alternative and
      complementary treatments that may lack an evidence base? - Yes.
PG  - 78
FAU - Pirotta, Marie V
AU  - Pirotta MV
AD  - Department of General Practice, University of Melbourne, Melbourne, VIC,
      Australia. m.pirotta@unimelb.edu.au
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Med J Aust
JT  - The Medical journal of Australia
JID - 0400714
SB  - IM
CIN - Med J Aust. 2011 Jul 18;195(2):79. PMID: 21770876
CIN - Med J Aust. 2011 Oct 17;195(8):450-2. PMID: 22004391
CIN - Med J Aust. 2011 Dec 19;195(11-12):660-1. PMID: 22171856
MH  - Australia
MH  - Complementary Therapies/*ethics
MH  - Evidence-Based Medicine/*ethics
MH  - General Practitioners/ethics
MH  - Humans
MH  - Physician-Patient Relations
EDAT- 2011/07/21 06:00
MHDA- 2011/09/22 06:00
CRDT- 2011/07/21 06:00
PHST- 2011/04/29 00:00 [received]
PHST- 2011/05/27 00:00 [accepted]
PHST- 2011/07/21 06:00 [entrez]
PHST- 2011/07/21 06:00 [pubmed]
PHST- 2011/09/22 06:00 [medline]
AID - pir10530_fm [pii]
AID - 10.5694/j.1326-5377.2011.tb03211.x [doi]
PST - ppublish
SO  - Med J Aust. 2011 Jul 18;195(2):78. doi: 10.5694/j.1326-5377.2011.tb03211.x.


PMID- 21770064
OWN - NLM
STAT- MEDLINE
DCOM- 20110823
LR  - 20190918
IS  - 1532-7361 (Electronic)
IS  - 0039-6060 (Linking)
VI  - 149
IP  - 6
DP  - 2011 Jun
TI  - A surgeon coerced under the Taliban: an ethical dilemma.
PG  - 825-9
FAU - Kruse, Lisa
AU  - Kruse L
AD  - Department of Orthopedic Surgery, Washington University School of Medicine, Saint
      Louis, MO 63131, USA.
FAU - Iqbal, Atif
AU  - Iqbal A
FAU - Aziz, Abdulhameed
AU  - Aziz A
FAU - Kodner, Ira J
AU  - Kodner IJ
FAU - Keune, Jason D
AU  - Keune JD
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Surgery
JT  - Surgery
JID - 0417347
SB  - IM
MH  - Afghanistan
MH  - Amputation/*ethics
MH  - *Coercion
MH  - *Culture
MH  - *Ethics, Medical
MH  - Humans
MH  - Leg/surgery
MH  - Physicians/*ethics
MH  - Religion
EDAT- 2011/07/20 06:00
MHDA- 2011/08/24 06:00
CRDT- 2011/07/20 06:00
PHST- 2011/07/20 06:00 [entrez]
PHST- 2011/07/20 06:00 [pubmed]
PHST- 2011/08/24 06:00 [medline]
AID - S0039-6060(11)00162-0 [pii]
AID - 10.1016/j.surg.2011.04.001 [doi]
PST - ppublish
SO  - Surgery. 2011 Jun;149(6):825-9. doi: 10.1016/j.surg.2011.04.001.


PMID- 21769980
OWN - NLM
STAT- MEDLINE
DCOM- 20120202
LR  - 20191210
IS  - 1522-2586 (Electronic)
IS  - 1053-1807 (Linking)
VI  - 34
IP  - 4
DP  - 2011 Oct
TI  - Dynamic phantom with heart, lung, and blood motion for initial validation of MRI 
      techniques.
PG  - 941-6
LID - 10.1002/jmri.22688 [doi]
AB  - PURPOSE: To develop an anthropomorphic phantom to simulate heart, lung, and blood
      motion. Magnetic resonance imaging (MRI) is sensitive to image distortion and
      artifacts caused by motion. Imaging phantoms are used to test new sequences, but 
      generally, these phantoms lack physiological motion. For the validation of new
      MR-based endovascular interventional and other techniques, we developed a dynamic
      motion phantom that is suitable for initial in vitro and more realistic
      validation studies that should occur before animal experiments. MATERIALS AND
      METHODS: An anthropomorphic phantom was constructed to model the thoracic cavity,
      including respiratory and cardiac motions, and moving blood. Several MRI methods 
      were used to validate the phantom performance: anatomical scanning, rapid
      temporal imaging, digital subtraction angiography, and endovascular tracking. The
      quality and nature of the motion artifact in these images were compared with in
      vivo images. RESULTS: The closed-loop motion phantom correctly represented key
      features in the thorax, was MR-compatible, and was able to reproduce similar
      motion artifacts and effects as seen in in vivo images. The phantom provided
      enough physiological realism that it was able to ensure a suitable challenge in
      an in vitro catheter tracking experiment. CONCLUSION: A phantom was created and
      used for testing interventional catheter guiding. The images produced had similar
      qualities to those found in vivo. This phantom had a high degree of appropriate
      anthropomorphic and physiological qualities. Ethically, use of this phantom is
      highly appropriate when first testing new MRI techniques prior to conducting
      animal studies.
CI  - Copyright (c) 2011 Wiley-Liss, Inc.
FAU - Swailes, Nolan E
AU  - Swailes NE
AD  - Department of Mechanical and Manufacturing Engineering, University of Calgary,
      Calgary, Alberta, Canada.
FAU - MacDonald, Matthew Ethan
AU  - MacDonald ME
FAU - Frayne, Richard
AU  - Frayne R
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20110718
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
SB  - IM
MH  - Animals
MH  - Blood Flow Velocity/physiology
MH  - Dogs
MH  - Heart/physiology
MH  - Humans
MH  - In Vitro Techniques
MH  - Lung/physiology
MH  - Magnetic Resonance Angiography/methods
MH  - Magnetic Resonance Imaging/*methods
MH  - Magnetic Resonance Imaging, Interventional/methods
MH  - Models, Animal
MH  - Models, Cardiovascular
MH  - Motion
MH  - *Phantoms, Imaging
MH  - Sensitivity and Specificity
EDAT- 2011/07/20 06:00
MHDA- 2012/02/03 06:00
CRDT- 2011/07/20 06:00
PHST- 2010/10/12 00:00 [received]
PHST- 2011/05/23 00:00 [accepted]
PHST- 2011/07/20 06:00 [entrez]
PHST- 2011/07/20 06:00 [pubmed]
PHST- 2012/02/03 06:00 [medline]
AID - 10.1002/jmri.22688 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2011 Oct;34(4):941-6. doi: 10.1002/jmri.22688. Epub 2011
      Jul 18.


PMID- 21769624
OWN - NLM
STAT- MEDLINE
DCOM- 20120418
LR  - 20211020
IS  - 1435-1544 (Electronic)
IS  - 0938-7412 (Linking)
VI  - 22
IP  - 3
DP  - 2011 Sep
TI  - [Treating ICD patients at the end of their lives: attitudes, knowledge, and
      behavior of doctors and patients. A critical literature analysis].
PG  - 151-6
LID - 10.1007/s00399-011-0138-x [doi]
AB  - BACKGROUND: The implantable cardioverter-defibrillator (ICD) is highly effective 
      in the therapy of malign heart rhythm abnormalities. However, the ethical dilemma
      of harming a dying patient has received little attention. We studied the current 
      state of knowledge and behavior of physicians and the subjective needs of ICD
      patients with respect to end-of-life issues. METHODS: A literature search of
      articles published between 8/2010 and 3/2011 in PubMed resulted in the
      identification of 32 reports, of which 25 met selection criteria. RESULTS:
      Practically no clinical institution (96% in Europe) offers routine counseling of 
      ICD patients on end-of-life issues. In only about 25% of cases do doctors
      initiate a discussion on this issue with the ICD patient, of which the majority
      takes place during the final hours of the patient's life. Knowledge of legal
      aspects of ICD deactivation is insufficient in about 50% of physicians. Many
      physicians underestimate the impact of ICD shocks and often have unrealistic
      expectations about the patient's knowledge on technical aspects of the ICD
      device. The majority of patients are reluctant to address this topic and prefer
      to rely on the decision of their attending physician. CONCLUSION: Despite
      insufficient empirical data, findings point to a low willingness of ICD patients 
      to confront the end-of-life issue and prefer decisions to be made by their
      physician. Substantial knowledge gaps of physicians may cause barriers in
      considering the option of deactivating the ICD.
FAU - Ladwig, K-H
AU  - Ladwig KH
AD  - Institut fur Epidemiologie (EPI-II), Helmholtz Zentrum Munchen, Deutsches
      Forschungszentrum fur Gesundheit und Umwelt, Ingolstadter Landstr. 1, 85764,
      Neuherberg, Deutschland. ladwig@helmholtz-muenchen.de
FAU - Ischinger, N F
AU  - Ischinger NF
FAU - Ronel, J
AU  - Ronel J
FAU - Kolb, C
AU  - Kolb C
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Umgang mit ICD-Patienten an ihrem Lebensende: Einstellungen, Wissen und Verhalten
      von Arzten und Patienten. Eine kritische Literaturanalyse.
PL  - Germany
TA  - Herzschrittmacherther Elektrophysiol
JT  - Herzschrittmachertherapie & Elektrophysiologie
JID - 9425873
SB  - IM
MH  - Attitude of Health Personnel
MH  - Communication
MH  - Communication Barriers
MH  - Counseling/ethics/legislation & jurisprudence
MH  - Data Collection
MH  - Defibrillators, Implantable/*ethics/*psychology
MH  - Device Removal/ethics/legislation & jurisprudence/psychology
MH  - *Ethics, Medical
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Patient Education as Topic/ethics/legislation & jurisprudence
MH  - Patient Participation/legislation & jurisprudence/psychology
MH  - Physician-Patient Relations/*ethics
MH  - Terminal Care/*ethics/legislation & jurisprudence/*methods/*psychology
EDAT- 2011/07/20 06:00
MHDA- 2012/04/19 06:00
CRDT- 2011/07/20 06:00
PHST- 2011/07/20 06:00 [entrez]
PHST- 2011/07/20 06:00 [pubmed]
PHST- 2012/04/19 06:00 [medline]
AID - 10.1007/s00399-011-0138-x [doi]
PST - ppublish
SO  - Herzschrittmacherther Elektrophysiol. 2011 Sep;22(3):151-6. doi:
      10.1007/s00399-011-0138-x.


PMID- 21769593
OWN - NLM
STAT- MEDLINE
DCOM- 20131126
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 1
DP  - 2013 Mar
TI  - Observations on the responsible development and use of computational models and
      simulations.
PG  - 63-81
LID - 10.1007/s11948-011-9291-1 [doi]
AB  - Most previous works on responsible conduct of research have focused on good
      practices in laboratory experiments. Because computation now rivals
      experimentation as a mode of scientific research, we sought to identify the
      responsibilities of researchers who develop or use computational modeling and
      simulation. We interviewed nineteen experts to collect examples of ethical issues
      from their experiences in conducting research with computational models. We
      gathered their recommendations for guidelines for computational research.
      Informed by these interviews, we describe the respective professional
      responsibilities of developers and users of computational models in research. In 
      particular, we examine whether developers should disclose the full computational 
      codes, and we explain how developers and users should minimize harms from
      improper uses of models.
FAU - Kijowski, David J
AU  - Kijowski DJ
AD  - Department of Mechanical Science and Engineering, University of Illinois, Urbana,
      IL, USA.
FAU - Dankowicz, Harry
AU  - Dankowicz H
FAU - Loui, Michael C
AU  - Loui MC
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20110717
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Computer Simulation/*ethics
MH  - Disclosure
MH  - *Ethics, Research
MH  - Guidelines as Topic
MH  - Humans
MH  - Interviews as Topic
MH  - *Models, Theoretical
MH  - Scientific Misconduct
MH  - *Social Responsibility
EDAT- 2011/07/20 06:00
MHDA- 2013/12/16 06:00
CRDT- 2011/07/20 06:00
PHST- 2011/03/27 00:00 [received]
PHST- 2011/06/20 00:00 [accepted]
PHST- 2011/07/20 06:00 [entrez]
PHST- 2011/07/20 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1007/s11948-011-9291-1 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Mar;19(1):63-81. doi: 10.1007/s11948-011-9291-1. Epub 2011
      Jul 17.


PMID- 21769592
OWN - NLM
STAT- MEDLINE
DCOM- 20131126
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 1
DP  - 2013 Mar
TI  - Incorporating global components into ethics education.
PG  - 287-98
LID - 10.1007/s11948-011-9295-x [doi]
AB  - Ethics is central to science and engineering. Young engineers need to be grounded
      in how corporate social responsibility principles can be applied to engineering
      organizations to better serve the broader community. This is crucial in times of 
      climate change and ecological challenges where the vulnerable can be impacted by 
      engineering activities. Taking a global perspective in ethics education will help
      ensure that scientists and engineers can make a more substantial contribution to 
      development throughout the world. This paper presents the importance of
      incorporating the global and cross culture components in the ethic education. The
      authors bring up a question to educators on ethics education in science and
      engineering in the globalized world, and its importance, necessity, and
      impendency. The paper presents several methods for discussion that can be used to
      identify the differences in ethics standards and practices in different
      countries; enhance the student's knowledge of ethics in a global arena.
FAU - Wang, George
AU  - Wang G
AD  - East Carolina University, Greenville, NC 27858, USA. wangg@ecu.edu
FAU - Thompson, Russell G
AU  - Thompson RG
LA  - eng
PT  - Journal Article
DEP - 20110716
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Culture
MH  - Ecology
MH  - Engineering/*ethics
MH  - Ethics, Professional/*education
MH  - Global Warming
MH  - Humans
MH  - *Internationality
MH  - Science/*ethics
MH  - *Social Responsibility
EDAT- 2011/07/20 06:00
MHDA- 2013/12/16 06:00
CRDT- 2011/07/20 06:00
PHST- 2011/03/14 00:00 [received]
PHST- 2011/07/05 00:00 [accepted]
PHST- 2011/07/20 06:00 [entrez]
PHST- 2011/07/20 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1007/s11948-011-9295-x [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Mar;19(1):287-98. doi: 10.1007/s11948-011-9295-x. Epub 2011 
      Jul 16.


PMID- 21769521
OWN - NLM
STAT- MEDLINE
DCOM- 20130318
LR  - 20211020
IS  - 0973-7693 (Electronic)
IS  - 0019-5456 (Linking)
VI  - 79
IP  - 1
DP  - 2012 Jan
TI  - Parental reporting of quality of care as a determinant of health related quality 
      of life of ill adolescents at a tertiary care hospital in northern India.
PG  - 62-7
LID - 10.1007/s12098-011-0528-4 [doi]
AB  - OBJECTIVE: To assess if Quality of Care (QoC) is a determinant of Health Related 
      Quality of Life (HRQoL) in ill adolescents. METHODS: This Cross-sectional study, 
      at a tertiary care hospital of Northern India was conducted after institutional
      ethical approval on ill adolescents availing ambulatory or in-patient care from
      Pediatrics department. From August 2009 through November 2010, 300 patients
      availing ambulatory or in-patient care were recruited, with mean age 11.5 years
      +/-1.5SD, of which 65.7% were males. After obtaining parental written consent and
      oral assent from subjects, parents reported their perception of QoC as well as
      adolescent's HRQoL through Pyramid and culturally modified WHOQOL-BREF,
      respectively. Pyramid (score range 0-1) has 43 questions about awareness of 8
      indices; namely illness, routines, accessibility, medical treatment, care
      processes, staff attitude, participation and staff work environment. WHOQOL-BREF 
      (score range 0-100) has 4 domains: physical, psychological, social relations and 
      environment. RESULTS: Mean HRQoL was 42.5 +/- 5.6, mean QoC was 0.67 +/- 0.07 and
      mean scores were not significantly different for patients on ambulatory and
      in-patient care. Correlation between overall HRQoL and QoC was 0.32 (p < 0.0001).
      Information about illness index was the only significant determinant of good
      HRQoL in binary logistic regression (Odd's Ratio 4.19, 95% CI 2.39-7.33; p <
      0.0001). CONCLUSIONS: QoC is a significant determinant of ill adolescent's HRQoL 
      at a tertiary care hospital.
FAU - Agnihotri, Kasturi
AU  - Agnihotri K
AD  - Department of Pediatrics, Chhatrapati Shahuji Maharaj Medical University
      (Erstwhile King George's Medical University), Shahmina Road, Chowk, Lucknow, UP
      226003, India.
FAU - Awasthi, Shally
AU  - Awasthi S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110719
PL  - India
TA  - Indian J Pediatr
JT  - Indian journal of pediatrics
JID - 0417442
SB  - IM
MH  - Adolescent
MH  - Adolescent Health Services/*standards
MH  - Child
MH  - Cross-Sectional Studies
MH  - Female
MH  - Hospitals
MH  - Humans
MH  - India
MH  - Male
MH  - Patient Satisfaction/*statistics & numerical data
MH  - Perception
MH  - Quality of Health Care/*statistics & numerical data
MH  - *Quality of Life
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2011/07/20 06:00
MHDA- 2013/03/19 06:00
CRDT- 2011/07/20 06:00
PHST- 2011/02/18 00:00 [received]
PHST- 2011/06/29 00:00 [accepted]
PHST- 2011/07/20 06:00 [entrez]
PHST- 2011/07/20 06:00 [pubmed]
PHST- 2013/03/19 06:00 [medline]
AID - 10.1007/s12098-011-0528-4 [doi]
PST - ppublish
SO  - Indian J Pediatr. 2012 Jan;79(1):62-7. doi: 10.1007/s12098-011-0528-4. Epub 2011 
      Jul 19.


PMID- 21769147
OWN - NLM
STAT- MEDLINE
DCOM- 20111121
LR  - 20211020
IS  - 1553-6467 (Electronic)
IS  - 0002-9459 (Linking)
VI  - 75
IP  - 4
DP  - 2011 May 10
TI  - A module on death and dying to develop empathy in student pharmacists.
PG  - 71
AB  - OBJECTIVE: To implement an integrated module on death and dying into a 15-week
      bioethics course and determine whether it increased student pharmacists' empathy.
      DESIGN: Students participated in a 5-week death and dying module that included
      presentation of the film Wit, an interactive lecture on hospice, and a lecture on
      the ethics of pain management. ASSESSMENT: Fifty-six students completed the
      30-item Balanced Emotional Empathy Scale (BEES) before and after completing the
      module and wrote a reflective essay. Students demonstrated an appreciation of
      patient-specific values in their essay. Quantitative data collected via BEES
      scores demonstrated significant improvement in measured empathy. CONCLUSION: A
      5-week instructional model on death and dying significantly increased student
      empathy.
FAU - Manolakis, Michael L
AU  - Manolakis ML
AD  - Wingate University School of Pharmacy, NC 28174-0159, USA. mmanolakis@wingate.edu
FAU - Olin, Jacqueline L
AU  - Olin JL
FAU - Thornton, Phillip L
AU  - Thornton PL
FAU - Dolder, Christian R
AU  - Dolder CR
FAU - Hanrahan, Conor
AU  - Hanrahan C
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Pharm Educ
JT  - American journal of pharmaceutical education
JID - 0372650
SB  - IM
MH  - Death
MH  - *Education, Pharmacy
MH  - *Empathy
MH  - *Ethics, Pharmacy
MH  - Female
MH  - Humans
MH  - Male
MH  - *Pharmacists
MH  - *Students, Pharmacy
PMC - PMC3138342
OTO - NOTNLM
OT  - death
OT  - dying
OT  - empathy
OT  - end-of-life care
EDAT- 2011/07/20 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/20 06:00
PHST- 2010/12/03 00:00 [received]
PHST- 2011/02/17 00:00 [accepted]
PHST- 2011/07/20 06:00 [entrez]
PHST- 2011/07/20 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.5688/ajpe75471 [doi]
PST - ppublish
SO  - Am J Pharm Educ. 2011 May 10;75(4):71. doi: 10.5688/ajpe75471.


PMID- 21769145
OWN - NLM
STAT- MEDLINE
DCOM- 20111121
LR  - 20211020
IS  - 1553-6467 (Electronic)
IS  - 0002-9459 (Linking)
VI  - 75
IP  - 4
DP  - 2011 May 10
TI  - Effect of dispositional traits on pharmacy students' attitude toward cheating.
PG  - 69
AB  - OBJECTIVE: To explore the relation between dispositional traits and pharmacy
      students' attitudes toward cheating in a university setting. METHODS: A
      questionnaire was administered primarily to pharmacy students at a comprehensive 
      university in the southeastern United States to assess self-esteem,
      self-efficacy, idealism, relativism, student attitudes toward cheating, tolerance
      for peer cheating, detachment from the university, Machiavellian behavior, and
      demographic information. RESULTS: Gender, degree of idealism, relativism, and
      Machiavellian traits were found to influence student attitudes toward cheating,
      while age, grade-point average (GPA), race, income, and marital status did not.
      CONCLUSIONS: Considered collectively, these data support the study model
      prediction that the major determinants of student attitudes toward cheating are
      based on the degree of idealism and relativism evident in the students'
      dispositional trait. Idealism was found to be inversely related to the likelihood
      of a student engaging in cheating or tolerating peer cheating.
FAU - Saulsbury, Marilyn D
AU  - Saulsbury MD
AD  - Hampton University School of Business, VA 23668, USA.
      marilyn.saulsbury@hamptonu.edu
FAU - Brown, Ulysses J 3rd
AU  - Brown UJ 3rd
FAU - Heyliger, Simone O
AU  - Heyliger SO
FAU - Beale, Ruby L
AU  - Beale RL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Pharm Educ
JT  - American journal of pharmaceutical education
JID - 0372650
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Attitude
MH  - *Deception
MH  - Female
MH  - Humans
MH  - Male
MH  - Self Concept
MH  - Self Efficacy
MH  - Sex Characteristics
MH  - Students, Pharmacy/*psychology
PMC - PMC3138350
OTO - NOTNLM
OT  - attitudes
OT  - behavior
OT  - cheating
OT  - ethics
OT  - pharmacy students
EDAT- 2011/07/20 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/20 06:00
PHST- 2010/08/25 00:00 [received]
PHST- 2011/01/18 00:00 [accepted]
PHST- 2011/07/20 06:00 [entrez]
PHST- 2011/07/20 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.5688/ajpe75469 [doi]
PST - ppublish
SO  - Am J Pharm Educ. 2011 May 10;75(4):69. doi: 10.5688/ajpe75469.


PMID- 21768747
OWN - NLM
STAT- MEDLINE
DCOM- 20120305
LR  - 20191210
IS  - 1348-4400 (Electronic)
IS  - 0916-8818 (Linking)
VI  - 57
IP  - 5
DP  - 2011 Oct
TI  - Promoting the "3Rs" principle in developmental biology with early and convenient 
      diagnosis of pregnancy in mice.
PG  - 655-9
AB  - The 3Rs stand for Replacement of animals in experiments, Reduction in the number 
      of experimental animals, and Refinement of experiments to minimize animal pain
      and stress. We propose to address Reduction and Refinement in the use of mice as 
      experimental models in developmental research. This study focuses on the maternal
      percentage of weight increase at gestational day 8 (%WI(GD8)) to diagnose
      pregnancy early in BALB/c mice. We documented sensitivity, specificity, false
      positive and negative rates and probability of pregnancy associated with
      %WI(GD8). This predictive model of pregnancy allows for significant reduction in 
      the number of mice to be sacrificed in developmental research. Reported
      observations and literature suggest that this model is independent of litter size
      and should be applicable to other mice strains. This procedure allows mice
      pregnancy detection before midgestation and proposes an ethically sound approach 
      to experimental animal use by optimizing the number of mice used and refining
      animal manipulation.
FAU - Seaborn, Tommy
AU  - Seaborn T
AD  - Reproduction, Perinatal and Child Health Axis, Centre Hospitalier Universitaire
      de Quebec, Centre Hospitalier de l'Universite Laval, Quebec, QC, Canada.
FAU - Moulin, Julie-Alexandra
AU  - Moulin JA
FAU - Cote, Melissa
AU  - Cote M
FAU - Tremblay, Yves
AU  - Tremblay Y
LA  - eng
GR  - MOP74531/Canadian Institutes of Health Research/Canada
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110716
PL  - Japan
TA  - J Reprod Dev
JT  - The Journal of reproduction and development
JID - 9438792
SB  - IM
MH  - Animals
MH  - Behavior, Animal/physiology
MH  - Concept Formation
MH  - Developmental Biology/*methods/standards
MH  - Early Diagnosis
MH  - False Positive Reactions
MH  - Female
MH  - Handling, Psychological
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Pregnancy
MH  - Pregnancy Tests/*methods/standards/statistics & numerical data/veterinary
MH  - *Pregnancy, Animal
MH  - Sensitivity and Specificity
EDAT- 2011/07/20 06:00
MHDA- 2012/03/06 06:00
CRDT- 2011/07/20 06:00
PHST- 2011/07/20 06:00 [entrez]
PHST- 2011/07/20 06:00 [pubmed]
PHST- 2012/03/06 06:00 [medline]
AID - JST.JSTAGE/jrd/11-073A [pii]
AID - 10.1262/jrd.11-073a [doi]
PST - ppublish
SO  - J Reprod Dev. 2011 Oct;57(5):655-9. doi: 10.1262/jrd.11-073a. Epub 2011 Jul 16.


PMID- 21768707
OWN - NLM
STAT- MEDLINE
DCOM- 20111128
LR  - 20110719
IS  - 1998-4138 (Electronic)
IS  - 1998-4138 (Linking)
VI  - 7
IP  - 2
DP  - 2011 Apr-Jun
TI  - Serum phosphodiesterase levels in oral cancer.
PG  - 180-2
LID - 10.4103/0973-1482.82911 [doi]
AB  - BACKGROUND: Oral squamous cell carcinoma (OSCC) is one of the most common
      malignancies recognized nowadays. Its early detection is the better alternative
      to provide a good quality of life for the patients. During the last years,
      several studies have identified potential biomarkers of OSCC progression and
      prognosis. The phosphodiesterases (PDEs) are responsible for the hydrolysis of
      the second messengers with a fundamental role in the transduction of the
      intracellular signals. Variations in PDE activity have been correlated to
      different pathological mechanisms, such as cellular differentiation, apoptosis,
      and tumor invasivity. PDEs are also known to play a role in tumor growth by
      influencing angiogenesis. AIM: To estimate and compare serum PDE levels in
      healthy controls and biopsy-proven oral cancer patients before definitive
      therapy. MATERIALS AND METHODS: Institutional Ethics Committee gave us the
      permission to conduct this study. After obtaining consent from biopsy-proven oral
      cancer patients (n = 39) (before onset of any definitive treatment) and age- and 
      sex-matched healthy controls (n = 20), 2 ml of blood was collected in plain
      vacutainers. After clot formation, samples were centrifuged and serum was
      collected for estimation of PDE. STATISTICAL ANALYSIS: Kruskal-Wallis test;
      Mann-Whitney Test. RESULTS AND DISCUSSION: Pretreatment PDE levels were
      significantly elevated in oral cancer patients (P<0.0001) as compared with the
      controls and also there was a significant increase in PDE levels (P<0.001) with
      advancing stage in oral cancer patients. This may implicate a role for serum PDE 
      in pathophysiology of oral cancer.
FAU - Prabhu, K
AU  - Prabhu K
AD  - Department of Biochemistry, Kasturba Medical College, Manipal University,
      Manipal, India.
FAU - Naik, D
AU  - Naik D
FAU - Ray, S
AU  - Ray S
FAU - Vadiraja, B M
AU  - Vadiraja BM
FAU - Kamath, A
AU  - Kamath A
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Cancer Res Ther
JT  - Journal of cancer research and therapeutics
JID - 101249598
RN  - EC 3.1.4.- (Phosphoric Diester Hydrolases)
SB  - IM
MH  - Adult
MH  - Carcinoma, Squamous Cell/*blood/diagnosis
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mouth Neoplasms/*blood/diagnosis
MH  - Phosphoric Diester Hydrolases/*blood
MH  - Prognosis
MH  - Statistics, Nonparametric
EDAT- 2011/07/20 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/20 06:00
PHST- 2011/07/20 06:00 [entrez]
PHST- 2011/07/20 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - JCanResTher_2011_7_2_180_82911 [pii]
AID - 10.4103/0973-1482.82911 [doi]
PST - ppublish
SO  - J Cancer Res Ther. 2011 Apr-Jun;7(2):180-2. doi: 10.4103/0973-1482.82911.


PMID- 21768618
OWN - NLM
STAT- MEDLINE
DCOM- 20120322
LR  - 20151119
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 1
DP  - 2012 Jan
TI  - Conscientious objection in medical students: a questionnaire survey.
PG  - 22-5
LID - 10.1136/jme.2011.042770 [doi]
AB  - OBJECTIVE: To explore attitudes towards conscientious objections among medical
      students in the UK. METHODS: Medical students at St George's University of
      London, Cardiff University, King's College London and Leeds University were
      emailed a link to an anonymous online questionnaire, hosted by an online survey
      company. The questionnaire contained nine questions. A total of 733 medical
      students responded. RESULTS: Nearly half of the students in this survey stated
      that they believed in the right of doctors to conscientiously object to any
      procedure. Demand for the right to conscientiously object is greater in Muslim
      medical students when compared with other groups of religious medical students.
      DISCUSSION: Abortion continues to be a contentious issue among medical students
      and this may contribute to the looming crisis in abortion services over the
      coming years. This project sheds some light on how future doctors view some of
      their ethical rights and obligations. Using empirical evidence, it reveals that
      conscientious objection is an issue in the UK medical student body today. These
      data could help anticipate problems that may arise when these medical students
      qualify and practise medicine in the community. CONCLUSION: Clearer guidance is
      needed for medical students about the issue of conscientious objection at medical
      school.
FAU - Strickland, Sophie Lm
AU  - Strickland SL
AD  - King George Hospital, Barking, Hevering and Redbridge University Hospitals,
      Essex, UK. sophiestrickland@doctors.net.uk
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20110718
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Abortion, Induced
MH  - Abortion, Legal/ethics
MH  - Attitude
MH  - *Conscience
MH  - Female
MH  - Human Rights
MH  - Humans
MH  - Morals
MH  - Pregnancy
MH  - Refusal to Treat/*ethics
MH  - Religion and Medicine
MH  - Students, Medical/*psychology
MH  - Surveys and Questionnaires
EDAT- 2011/07/20 06:00
MHDA- 2012/03/23 06:00
CRDT- 2011/07/20 06:00
PHST- 2011/07/20 06:00 [entrez]
PHST- 2011/07/20 06:00 [pubmed]
PHST- 2012/03/23 06:00 [medline]
AID - jme.2011.042770 [pii]
AID - 10.1136/jme.2011.042770 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Jan;38(1):22-5. doi: 10.1136/jme.2011.042770. Epub 2011 Jul
      18.


PMID- 21768611
OWN - NLM
STAT- MEDLINE
DCOM- 20111208
LR  - 20211020
IS  - 1535-7228 (Electronic)
IS  - 0002-953X (Linking)
VI  - 168
IP  - 10
DP  - 2011 Oct
TI  - Treatment of suicide attempters with bipolar disorder: a randomized clinical
      trial comparing lithium and valproate in the prevention of suicidal behavior.
PG  - 1050-6
LID - 10.1176/appi.ajp.2011.11010163 [doi]
AB  - OBJECTIVE: Bipolar disorder is associated with high risk for suicidal acts.
      Observational studies suggest a protective effect of lithium against suicidal
      behavior. However, testing this effect in randomized clinical trials is
      logistically and ethically challenging. The authors tested the hypothesis that
      lithium offers bipolar patients with a history of suicide attempt greater
      protection against suicidal behavior compared to valproate. METHOD: Patients with
      bipolar disorder and past suicide attempts (N=98) were randomly assigned to
      treatment with lithium or valproate, plus adjunctive medications as indicated, in
      a double-blind 2.5-year trial. An intent-to-treat analysis was performed using
      the log-rank test for survival data. Two models were fitted: time to suicide
      attempt and time to suicide event (attempt or hospitalization or change in
      medication in response to suicide plans). RESULTS: There were 45 suicide events
      in 35 participants, including 18 suicide attempts made by 14 participants, six
      from the lithium group and eight from the valproate group. There were no
      suicides. Intent-to-treat analysis using the log-rank test showed no differences 
      between treatment groups in time to suicide attempt or to suicide event. Post hoc
      power calculations revealed that the modest sample size, reflective of challenges
      in recruitment, only permits detection of a relative risk of 5 or greater.
      CONCLUSIONS: Despite the high frequency of suicide events during the study, this 
      randomized controlled trial detected no difference between lithium and valproate 
      in time to suicide attempt or suicide event in a sample of suicide attempters
      with bipolar disorder. However, smaller clinically significant differences
      between the two drugs were not ruled out.
FAU - Oquendo, Maria A
AU  - Oquendo MA
AD  - Columbia University, New York State Psychiatric Institute, New York, USA.
      mao4@columbia.edu
FAU - Galfalvy, Hanga C
AU  - Galfalvy HC
FAU - Currier, Dianne
AU  - Currier D
FAU - Grunebaum, Michael F
AU  - Grunebaum MF
FAU - Sher, Leo
AU  - Sher L
FAU - Sullivan, Gregory M
AU  - Sullivan GM
FAU - Burke, Ainsley K
AU  - Burke AK
FAU - Harkavy-Friedman, Jill
AU  - Harkavy-Friedman J
FAU - Sublette, M Elizabeth
AU  - Sublette ME
FAU - Parsey, Ramin V
AU  - Parsey RV
FAU - Mann, J John
AU  - Mann JJ
LA  - eng
GR  - P20 AA015630/AA/NIAAA NIH HHS/United States
GR  - R01 MH059710/MH/NIMH NIH HHS/United States
GR  - MH AA15630/AA/NIAAA NIH HHS/United States
GR  - MH 59710/MH/NIMH NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110718
PL  - United States
TA  - Am J Psychiatry
JT  - The American journal of psychiatry
JID - 0370512
RN  - 0 (Antimanic Agents)
RN  - 614OI1Z5WI (Valproic Acid)
RN  - 9FN79X2M3F (Lithium)
SB  - IM
CIN - Am J Psychiatry. 2011 Oct;168(10):1009-11. PMID: 21969041
CIN - Am J Psychiatry. 2012 Jan;169(1):97-8; author reply 99. PMID: 22223015
CIN - Am J Psychiatry. 2012 Jan;169(1):98-9; author reply 99. PMID: 22223017
EIN - Am J Psychiatry. 2012 Feb;169(2):223
MH  - Adult
MH  - Antimanic Agents/*therapeutic use
MH  - Bipolar Disorder/*drug therapy
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Lithium/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Suicide/*prevention & control
MH  - Suicide, Attempted/*prevention & control
MH  - Treatment Outcome
MH  - Valproic Acid/*therapeutic use
PMC - PMC3767999
MID - NIHMS511136
EDAT- 2011/07/20 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/20 06:00
PHST- 2011/07/20 06:00 [entrez]
PHST- 2011/07/20 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - appi.ajp.2011.11010163 [pii]
AID - 10.1176/appi.ajp.2011.11010163 [doi]
PST - ppublish
SO  - Am J Psychiatry. 2011 Oct;168(10):1050-6. doi: 10.1176/appi.ajp.2011.11010163.
      Epub 2011 Jul 18.


PMID- 21768585
OWN - NLM
STAT- MEDLINE
DCOM- 20110926
LR  - 20141120
IS  - 1539-3704 (Electronic)
IS  - 0003-4819 (Linking)
VI  - 155
IP  - 2
DP  - 2011 Jul 19
TI  - Will cell reprogramming resolve the embryonic stem cell controversy? A narrative 
      review.
PG  - 114-21
LID - 10.7326/0003-4819-155-2-201107190-00007 [doi]
AB  - In the past few years, relatively straightforward laboratory techniques have been
      developed to reprogram normal body cells to enter an embryonic stem cell-like
      state. Not only do these induced pluripotent stem cells hold great medical
      promise--perhaps greater than that of embryonic stem cells--but they also have
      escaped the ethical controversy in which the latter is mired. This article
      examines how cell reprogramming is likely to transform regenerative and
      reproductive medicine and highlights some of the medical, moral, and political
      hurdles that it faces. It also argues that induced pluripotent stem cells are
      more ethically problematic than most people believe and that cell reprogramming
      will not solve the stem cell controversy but complicate it further.
FAU - Power, Carl
AU  - Power C
AD  - Centenary Institute, University of Sydney, and the Royal Prince Alfred Hospital, 
      Sydney, Australia.
FAU - Rasko, John E J
AU  - Rasko JE
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Ann Intern Med
JT  - Annals of internal medicine
JID - 0372351
SB  - IM
MH  - Cell Differentiation
MH  - Cell Proliferation
MH  - Cellular Reprogramming
MH  - *Embryonic Stem Cells
MH  - *Ethics, Medical
MH  - Humans
MH  - *Induced Pluripotent Stem Cells/cytology
MH  - Politics
MH  - Regenerative Medicine/ethics
EDAT- 2011/07/20 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/07/20 06:00
PHST- 2011/07/20 06:00 [entrez]
PHST- 2011/07/20 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 155/2/114 [pii]
AID - 10.7326/0003-4819-155-2-201107190-00007 [doi]
PST - ppublish
SO  - Ann Intern Med. 2011 Jul 19;155(2):114-21. doi:
      10.7326/0003-4819-155-2-201107190-00007.


PMID- 21767839
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20161229
IS  - 1879-3479 (Electronic)
IS  - 0020-7292 (Linking)
VI  - 114
IP  - 3
DP  - 2011 Sep
TI  - Denial of pain relief during labor to parturients in southeast Nigeria.
PG  - 226-8
LID - 10.1016/j.ijgo.2011.04.006 [doi]
AB  - OBJECTIVE: To evaluate the experiences of parturients with regard to pain relief 
      during labor in Enugu, Nigeria. METHODS: Women attending the prenatal clinics of 
      3 maternity care centers were interviewed via pre-tested interviewer-administered
      questionnaires between August 2010 and January 2011. Both open and closed
      questions were asked to evaluate the opinions and experiences of the respondents 
      with regard to labor analgesia in previous pregnancies. RESULTS: Overall, 34.1%
      of respondents were aware of their right to labor pain relief. Only 33.5% of
      maternal requests for labor pain relief were granted. Women who did not request
      labor analgesia indicated ignorance and fear of labor caregivers as their major
      reasons. CONCLUSION: Most women in southeast Nigeria are unaware of their right
      to pain relief in labor. Ignorance and fear of unfavorable reactions from labor
      caregivers are hindering women from requesting labor analgesia. There is a need
      to address the issue of refusal of maternal requests for labor pain relief
      because it constitutes a violation of the fundamental right of the parturient and
      an unnecessary breach of medical ethics.
CI  - Copyright (c) 2011. Published by Elsevier Ireland Ltd.
FAU - Chigbu, Chibuike O
AU  - Chigbu CO
AD  - Department of Obstetrics and Gynecology, University of Nigeria Teaching Hospital,
      Enugu, Nigeria. chchigbu@yahoo.com
FAU - Onyeka, Tonia C
AU  - Onyeka TC
LA  - eng
PT  - Journal Article
DEP - 20110720
PL  - United States
TA  - Int J Gynaecol Obstet
JT  - International journal of gynaecology and obstetrics: the official organ of the
      International Federation of Gynaecology and Obstetrics
JID - 0210174
SB  - IM
CIN - Int J Gynaecol Obstet. 2011 Sep;114(3):207-8. PMID: 21752375
MH  - Adult
MH  - Female
MH  - Humans
MH  - Labor Pain/psychology/*therapy
MH  - Nigeria
MH  - Pregnancy
MH  - Refusal to Treat/*statistics & numerical data
MH  - Young Adult
EDAT- 2011/07/20 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/20 06:00
PHST- 2011/03/08 00:00 [received]
PHST- 2011/03/31 00:00 [revised]
PHST- 2011/06/13 00:00 [accepted]
PHST- 2011/07/20 06:00 [entrez]
PHST- 2011/07/20 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0020-7292(11)00273-6 [pii]
AID - 10.1016/j.ijgo.2011.04.006 [doi]
PST - ppublish
SO  - Int J Gynaecol Obstet. 2011 Sep;114(3):226-8. doi: 10.1016/j.ijgo.2011.04.006.
      Epub 2011 Jul 20.


PMID- 21767834
OWN - NLM
STAT- MEDLINE
DCOM- 20120120
LR  - 20161229
IS  - 1879-3479 (Electronic)
IS  - 0020-7292 (Linking)
VI  - 115
IP  - 1
DP  - 2011 Oct
TI  - Medical, ethical, and legal considerations in fertility preservation.
PG  - 11-5
LID - 10.1016/j.ijgo.2011.05.011 [doi]
AB  - The past 2 decades have seen a significant rise in cancer survival rates, and an 
      increasing proportion of survivors at reproductive age are interested in
      childbearing. Although assisted reproduction provides physicians with an array of
      potential possibilities to help patients whose fertility is compromised by cancer
      treatment, there is still a dearth of regulation regarding the application of
      this technology. The present paper reviews the current options for fertility
      preservation, with a particular focus on the legal and ethical challenges that
      confront providers of this type of care.
CI  - Copyright (c) 2011 International Federation of Gynecology and Obstetrics.
      Published by Elsevier Ireland Ltd. All rights reserved.
FAU - Shah, Divya K
AU  - Shah DK
AD  - Division of Reproductive Endocrinology and Infertility, Department of Obstetrics,
      Gynecology, and Reproductive Biology, Brigham and Women's Hospital and Harvard
      Medical School, Boston 02115, USA. dkshah@partners.org
FAU - Goldman, Edward
AU  - Goldman E
FAU - Fisseha, Senait
AU  - Fisseha S
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110720
PL  - United States
TA  - Int J Gynaecol Obstet
JT  - International journal of gynaecology and obstetrics: the official organ of the
      International Federation of Gynaecology and Obstetrics
JID - 0210174
SB  - IM
MH  - Cryopreservation/ethics/*methods
MH  - Female
MH  - Fertility Preservation/ethics/legislation & jurisprudence/*methods
MH  - Humans
MH  - Infertility, Female/etiology
MH  - Infertility, Male/etiology
MH  - Male
MH  - Neoplasms/*therapy
MH  - Survivors
EDAT- 2011/07/20 06:00
MHDA- 2012/01/21 06:00
CRDT- 2011/07/20 06:00
PHST- 2011/02/25 00:00 [received]
PHST- 2011/05/17 00:00 [revised]
PHST- 2011/05/27 00:00 [accepted]
PHST- 2011/07/20 06:00 [entrez]
PHST- 2011/07/20 06:00 [pubmed]
PHST- 2012/01/21 06:00 [medline]
AID - S0020-7292(11)00311-0 [pii]
AID - 10.1016/j.ijgo.2011.05.011 [doi]
PST - ppublish
SO  - Int J Gynaecol Obstet. 2011 Oct;115(1):11-5. doi: 10.1016/j.ijgo.2011.05.011.
      Epub 2011 Jul 20.


PMID- 21767425
OWN - NLM
STAT- MEDLINE
DCOM- 20111005
LR  - 20110719
IS  - 1876-8784 (Electronic)
IS  - 0028-2162 (Linking)
VI  - 155
IP  - 26
DP  - 2011
TI  - [Ethical review of biobanks in The Netherlands: lessons from the String of Pearls
      Initiative].
PG  - A3557
AB  - Ethical and legal aspects of biobanking continue to be a topic of concern. The
      String of Pearls Initiative (PSI) helped establish new norms for biobank
      governance in The Netherlands. This article gives an overview of issues that
      emerged from the medical-ethical review processes of PSI. The criteria applied to
      biobanking projects by Ethical Review Boards were derived from the legally
      prescribed criteria for medical research. However, these criteria were
      interpreted in radically diverging ways. Key issues included the legal status of 
      prospective research-dedicated biobanks, informed consent, monitoring of the use 
      of biobanks, and alignment of biobanking policies both within and between
      research departments. The article calls on all actors involved in biobanking to
      continue to strive for the harmonization of biobanking policies. A certain degree
      of central coordination is crucial in order to improve on collaborative
      biobanking initiatives.
FAU - Boeckhout, Martin
AU  - Boeckhout M
AD  - Universiteit van Amsterdam, afd. Wijsbegeerte, Amsterdam, the Netherlands.
      m.boeckhout@uva.nl
FAU - van Dijk, Jet
AU  - van Dijk J
FAU - Legemate, Dink A
AU  - Legemate DA
LA  - dut
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Toetsing van biobanken: lessen uit het Parelsnoer Initiatief.
PL  - Netherlands
TA  - Ned Tijdschr Geneeskd
JT  - Nederlands tijdschrift voor geneeskunde
JID - 0400770
SB  - IM
MH  - *Bioethical Issues
MH  - Biological Specimen Banks/*ethics/organization & administration/standards
MH  - *Ethics Committees, Research
MH  - Health Policy/*legislation & jurisprudence
MH  - Humans
MH  - Netherlands
MH  - Personal Autonomy
EDAT- 2011/07/20 06:00
MHDA- 2011/10/06 06:00
CRDT- 2011/07/20 06:00
PHST- 2011/07/20 06:00 [entrez]
PHST- 2011/07/20 06:00 [pubmed]
PHST- 2011/10/06 06:00 [medline]
PST - ppublish
SO  - Ned Tijdschr Geneeskd. 2011;155(26):A3557.


PMID- 21767167
OWN - NLM
STAT- MEDLINE
DCOM- 20111219
LR  - 20191210
IS  - 1557-7740 (Electronic)
IS  - 1557-7740 (Linking)
VI  - 14
IP  - 8
DP  - 2011 Aug
TI  - Effects of a ninety-minute teaching module for fourth-year medical students on a 
      palliative care ward with student-patient encounter.
PG  - 940-4
LID - 10.1089/jpm.2011.0025 [doi]
AB  - BACKGROUND: The encounter of students and patients with a terminal illness plays 
      an important role in this teaching. However, for ethical as well as practical
      reasons, there are limitations regarding the involvement of patients in
      palliative care teaching. In this study we investigate the effects of an
      obligatory 90-minute teaching intervention on a palliative care ward by means of 
      quantitative and qualitative methods. METHODS: Self-perceived knowledge,
      confidence and attitudes were elicited by means of a questionnaire which has been
      developed by the authors. The instrument includes statements which could be
      answered by means of numerical rating scales - NRS (1 = very low, 10 = very
      high). In addition, open-ended questions regarding students' self-perceptions and
      evaluation of the teaching were analyzed according to the principles of content
      analysis. RESULTS: All 163 participants completed the questionnaire. Participants
      rated their knowledge in palliative care as poor prior to the course (median, 3).
      Medical students indicated significantly improved confidence regarding the
      encounter with patients in palliative care (p < 0.001; median, 3 before versus
      5.5 after), and higher interest for the subject of palliative care (median 7
      before vs. 8 after). The student-patient encounter could be identified as a
      relevant factor contributing to the positive evaluation as part of the analysis
      of qualitative data. CONCLUSIONS: This evaluation study of an obligatory course
      in palliative care indicates that even a short teaching module that includes a
      student-patient encounter has significant effects on the medical students'
      self-perceived knowledge, confidence and attitudes, and their interest in
      palliative care.
FAU - Weber, Martin
AU  - Weber M
AD  - Interdisciplinary Palliative Care Unit, University Medical Center of the Johannes
      Gutenberg University of Mainz, Mainz, Germany. martin.weber@unimedizin-mainz.de
FAU - Braun, Julia
AU  - Braun J
FAU - Schildmann, Jan
AU  - Schildmann J
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20110718
PL  - United States
TA  - J Palliat Med
JT  - Journal of palliative medicine
JID - 9808462
SB  - IM
MH  - Adult
MH  - *Education, Medical, Undergraduate
MH  - Female
MH  - Germany
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Male
MH  - *Palliative Care
MH  - *Physician-Patient Relations
MH  - Self Efficacy
MH  - Surveys and Questionnaires
MH  - Teaching/*methods
MH  - Young Adult
EDAT- 2011/07/20 06:00
MHDA- 2011/12/20 06:00
CRDT- 2011/07/20 06:00
PHST- 2011/07/20 06:00 [entrez]
PHST- 2011/07/20 06:00 [pubmed]
PHST- 2011/12/20 06:00 [medline]
AID - 10.1089/jpm.2011.0025 [doi]
PST - ppublish
SO  - J Palliat Med. 2011 Aug;14(8):940-4. doi: 10.1089/jpm.2011.0025. Epub 2011 Jul
      18.


PMID- 21767038
OWN - NLM
STAT- MEDLINE
DCOM- 20120103
LR  - 20130520
IS  - 1939-1544 (Electronic)
IS  - 0090-5550 (Linking)
VI  - 56
IP  - 3
DP  - 2011 Aug
TI  - The APA Ethical Principles as a foundational competency: application to
      rehabilitation psychology.
PG  - 219-30
LID - 10.1037/a0024206 [doi]
AB  - OVERVIEW: Competence is a core component of ethical conduct as reflected in its
      addition as an ethical standard in the 2002 APA Ethics Code. Successfully
      operationalizing and assessing competence provides psychologists a means to
      improve education and training, advance the field of practice, and create a
      framework for accountability to the public. Much of the recent competency
      discussion has been in response to a proposed Cube Model, with its three axes
      being foundational competencies (practice building blocks, such as scientific
      knowledge, ethical standards), functional competencies (attributes of providing
      services, such as assessment, intervention), and developmental progression
      (acquiring increasing competence over the course of one's education and career). 
      Ethics is included on the foundational competency axis and has been
      operationalized to the extent that subcomponents and benchmarks have been
      promulgated. The competency model as proposed faces multiple challenges,
      including gaining consensus regarding its components, addressing reliable and
      valid assessment over time, and creating a culture of acceptance. We propose the 
      Ethical Principles as an alternative framework for conceptualizing ethics as a
      foundational competency given the Ethics Code is already time tested and includes
      a serial review process for broad discipline input and adaptability. We apply the
      Ethical Principles as foundational components to rehabilitation psychology
      training at internship, postdoctoral, and specialty levels to illustrate the
      model. CONCLUSION: Rehabilitation psychology should engage in the competency
      movement at the predoctoral and postdoctoral level. The application of the
      Ethical Principles as a foundational competency to rehabilitation psychology
      represents a first step in this dialog.
FAU - Hanson, Stephanie L
AU  - Hanson SL
AD  - College of Public Health and Health Professions, University of Florida,
      Gainesville, FL 32611, USA. shanson@phhp.ufl.edu
FAU - Kerkhoff, Thomas R
AU  - Kerkhoff TR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Rehabil Psychol
JT  - Rehabilitation psychology
JID - 0365337
SB  - IM
MH  - *Benchmarking
MH  - *Codes of Ethics
MH  - Humans
MH  - Models, Theoretical
MH  - *Professional Competence
MH  - Psychology/*ethics
MH  - Rehabilitation/*ethics
MH  - Societies, Scientific
MH  - United States
EDAT- 2011/07/20 06:00
MHDA- 2012/01/04 06:00
CRDT- 2011/07/20 06:00
PHST- 2011/07/20 06:00 [entrez]
PHST- 2011/07/20 06:00 [pubmed]
PHST- 2012/01/04 06:00 [medline]
AID - 2011-14570-001 [pii]
AID - 10.1037/a0024206 [doi]
PST - ppublish
SO  - Rehabil Psychol. 2011 Aug;56(3):219-30. doi: 10.1037/a0024206.


PMID- 21766436
OWN - NLM
STAT- MEDLINE
DCOM- 20111223
LR  - 20211020
IS  - 1552-4876 (Electronic)
IS  - 1552-4868 (Linking)
VI  - 157C
IP  - 3
DP  - 2011 Aug 15
TI  - We don't know what we don't study: the case for research on medication effects in
      pregnancy.
PG  - 247-50
LID - 10.1002/ajmg.c.30309 [doi]
AB  - This Commentary addresses issues related to exposures to teratogens and makes the
      case for increased research into the safety of medication usage during pregnancy 
      for mothers and fetuses. Not only are medications commonly used during pregnancy,
      but evidence points to an increasing prevalence and number of drug exposures
      experienced by the embryo or fetus, particularly during the critical first
      trimester of pregnancy. Although the first trimester represents a particularly
      vulnerable period of organogenesis, exposures during other gestational time
      periods may also be associated with deleterious outcomes. In addition to the
      changing (and in many cases unknown) risks to a developing fetus, other
      challenges to studying medication exposures and their effects during pregnancy
      include the dramatic changes in physiology that occur in pregnant women and the
      ethical dilemmas posed by including this vulnerable population in randomized
      controlled trials of safety and efficacy. However, without adequate knowledge of 
      the pharmacokinetics, pharmacodynamics, efficacy, and safety of medication use in
      pregnancy, women may be under-dosed to minimize exposure or not treated at all,
      resulting in inadequate treatment and potential harm to the mother and her baby. 
      The Eunice Kennedy Shriver National Institute of Child Health and Human
      Development (NICHD) is undertaking studies on medications and teratogenic
      exposures during pregnancy, including alcohol, maternal diabetes, oral
      hypoglycemic agents, and antiviral medications, through several of its research
      networks. Although this is a start, there is a critical need for further research
      on medications used during pregnancy, especially their effects on both the mother
      and her developing child.
CI  - Published 2011 Wiley-Liss, Inc.
FAU - Parisi, Melissa A
AU  - Parisi MA
AD  - Intellectual and Developmental Disabilities Branch, Center for Developmental
      Biology and Perinatal Medicine, Eunice Kennedy Shriver National Institute of
      Child Health and Human Development, 6100 Executive Boulevard, Bethesda, MD
      20892-7510, USA. parisima@mail.nih.gov
FAU - Spong, Catherine Y
AU  - Spong CY
FAU - Zajicek, Anne
AU  - Zajicek A
FAU - Guttmacher, Alan E
AU  - Guttmacher AE
LA  - eng
GR  - Z99 HD999999/Intramural NIH HHS/United States
PT  - Journal Article
DEP - 20110715
PL  - United States
TA  - Am J Med Genet C Semin Med Genet
JT  - American journal of medical genetics. Part C, Seminars in medical genetics
JID - 101235745
RN  - 0 (Teratogens)
SB  - IM
MH  - Abnormalities, Drug-Induced/etiology/prevention & control
MH  - *Drug-Related Side Effects and Adverse Reactions
MH  - Female
MH  - Humans
MH  - Pregnancy
MH  - Pregnancy Complications/drug therapy
MH  - Pregnancy Outcome
MH  - Prenatal Exposure Delayed Effects/chemically induced/prevention & control
MH  - Risk Assessment
MH  - *Teratogens
PMC - PMC3140632
MID - NIHMS303596
EDAT- 2011/07/19 06:00
MHDA- 2011/12/24 06:00
CRDT- 2011/07/19 06:00
PHST- 2011/07/19 06:00 [entrez]
PHST- 2011/07/19 06:00 [pubmed]
PHST- 2011/12/24 06:00 [medline]
AID - 10.1002/ajmg.c.30309 [doi]
PST - ppublish
SO  - Am J Med Genet C Semin Med Genet. 2011 Aug 15;157C(3):247-50. doi:
      10.1002/ajmg.c.30309. Epub 2011 Jul 15.


PMID- 21766192
OWN - NLM
STAT- MEDLINE
DCOM- 20110929
LR  - 20211020
IS  - 1432-1203 (Electronic)
IS  - 0340-6717 (Linking)
VI  - 130
IP  - 3
DP  - 2011 Sep
TI  - Reflexive governance in biobanking: on the value of policy led approaches and the
      need to recognise the limits of law.
PG  - 347-56
LID - 10.1007/s00439-011-1066-x [doi]
AB  - Although a few jurisdictions around the world have legislated in response to the 
      phenomenon of biobanking, the far more common response has been policy led with
      funders and other stakeholders initiating multi-level policy initiatives to guide
      biobanking practice. An example of this is UK Biobank which has developed and
      operates according to an Ethics and Governance Framework. Such an instrument has 
      no basis in law and yet it has played a crucial role in the set up and ongoing
      management of the resource. It will continue to do so, as related policies
      emerge, such as access and intellectual property policies. Numerous biobanking
      initiatives have similar high-level policy documents that guide decisions and
      practice. These are often framed as a commitment to participants, researchers and
      society more broadly and invoke notions such as the public good and the public
      interest. As such, they serve as a benchmark against which to measure a biobank's
      performance. Moreover, policies become an important means by which biobankers are
      held accountable. This article critically analyses this policy-driven phenomenon 
      asking how effectively policy--often as an alternative to law--serves to police
      and to promote biobanking. It argues that a policy of reflexive
      governance--defined and developed herein--can best meet the challenges faced by
      many biobanks and without the need for recourse to law.
FAU - Laurie, Graeme
AU  - Laurie G
AD  - The Arts and Humanities Research Council, Research Centre for Studies in
      Intellectual Property and Technology Law, School of Law, University of Edinburgh,
      Old College, South Bridge, Edinburgh EH8-9YL, Scotland, UK.
      Graeme.Laurie@ed.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20110716
PL  - Germany
TA  - Hum Genet
JT  - Human genetics
JID - 7613873
SB  - IM
MH  - *Biological Specimen Banks/ethics/legislation & jurisprudence
MH  - *Policy Making
MH  - Professional Autonomy
MH  - Quality Control
MH  - *Social Control Policies
MH  - Social Responsibility
MH  - United Kingdom
MH  - United States
EDAT- 2011/07/19 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/07/19 06:00
PHST- 2011/05/30 00:00 [received]
PHST- 2011/07/05 00:00 [accepted]
PHST- 2011/07/19 06:00 [entrez]
PHST- 2011/07/19 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - 10.1007/s00439-011-1066-x [doi]
PST - ppublish
SO  - Hum Genet. 2011 Sep;130(3):347-56. doi: 10.1007/s00439-011-1066-x. Epub 2011 Jul 
      16.


PMID- 21766166
OWN - NLM
STAT- MEDLINE
DCOM- 20120224
LR  - 20211020
IS  - 1432-1076 (Electronic)
IS  - 0340-6199 (Linking)
VI  - 170
IP  - 11
DP  - 2011 Nov
TI  - Clinical practice: The approach to the deaf or hard-of-hearing paediatric
      patient.
PG  - 1359-63
LID - 10.1007/s00431-011-1530-6 [doi]
AB  - Approximately 1 child in 1,000 is deaf or severely hard of hearing from birth,
      and the prevalence rises to about 1.6 per 1,000 in adolescents. Providing medical
      care for this group of children poses special challenges for professionals. To
      allow a medical consultation to proceed successfully and to the satisfaction of
      the patient, it is essential that physicians are aware of the different
      linguistic and cultural background of these patients. Healthcare workers should
      be aware of the possible higher incidence of comorbidities, sexual abuse and
      (psycho)social problems, of the possible pitfalls in obtaining informed consent
      and higher frequency of medical mistakes. This review describes the communication
      challenges and medical, ethical and legal issues a physician can experience when 
      faced with these patients.
FAU - Smeijers, Anika S
AU  - Smeijers AS
AD  - Department of Paediatrics, Spaarne Hospital, Hoofddorp, the Netherlands.
      anika.smeijers@gmail.com
FAU - Ens-Dokkum, Martina H
AU  - Ens-Dokkum MH
FAU - van den Bogaerde, Beppie
AU  - van den Bogaerde B
FAU - Oudesluys-Murphy, Anne Marie
AU  - Oudesluys-Murphy AM
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110716
PL  - Germany
TA  - Eur J Pediatr
JT  - European journal of pediatrics
JID - 7603873
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child Development
MH  - Communication
MH  - Europe
MH  - *Hearing Loss/psychology
MH  - Humans
MH  - Informed Consent
MH  - *Pediatrics
MH  - *Persons With Hearing Impairments/psychology
MH  - *Physician-Patient Relations
MH  - Practice Guidelines as Topic
PMC - PMC3197921
EDAT- 2011/07/19 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/07/19 06:00
PHST- 2011/05/04 00:00 [received]
PHST- 2011/06/28 00:00 [accepted]
PHST- 2011/07/19 06:00 [entrez]
PHST- 2011/07/19 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - 10.1007/s00431-011-1530-6 [doi]
PST - ppublish
SO  - Eur J Pediatr. 2011 Nov;170(11):1359-63. doi: 10.1007/s00431-011-1530-6. Epub
      2011 Jul 16.


PMID- 21765946
OWN - NLM
STAT- MEDLINE
DCOM- 20111109
LR  - 20211020
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 6
IP  - 7
DP  - 2011
TI  - An empirical analysis of overlap publication in Chinese language and English
      research manuscripts.
PG  - e22149
LID - 10.1371/journal.pone.0022149 [doi]
AB  - BACKGROUND: There are a number of sound justifications for publishing nearly
      identical information in Chinese and English medical journals, assuming several
      conditions are met. Although overlap publication is perceived as undesirable and 
      ethically questionable in Europe and North America, it may serve an important
      function in some regions where English is not the native tongue. There is no
      empirical data on the nature and degree of overlap publication in English and
      Chinese language journals. METHODS/PRINCIPAL FINDINGS: A random sample of 100
      English manuscripts from Chinese institutions was selected from PubMed. Key words
      and institutions were searched in the China National Knowledge Infrastructure, a 
      comprehensive Chinese language research database. Unacknowledged overlap was a
      priori defined according to International Committee of Medical Journal Editor
      (ICMJE) guidelines following examination by two individuals. 19% (95% CI 11-27)
      of English manuscripts from Chinese institutions were found to have substantial
      overlap with Chinese published work based on full text examination. None of the
      manuscripts met all of the criteria established by the ICMJE for an acknowledged 
      overlap publication. Individual-level, journal-level, and institutional factors
      seem to influence overlap publication. Manuscripts associated with an institution
      outside of China and with more than one institution were significantly less
      likely to have substantial overlap (p<0.05). CONCLUSIONS/SIGNIFICANCE: Overlap
      publication was common in this context, but instances of standard ICMJE notations
      to acknowledge this practice were rare. This research did not cite the identified
      overlap manuscripts with the hope that these empirical data will inform journal
      policy changes and structural initiatives to promote clearer policies and
      manuscripts.
FAU - Tucker, Joseph D
AU  - Tucker JD
AD  - Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts,
      United States of America. jtucker4@partners.org
FAU - Chang, Helena
AU  - Chang H
FAU - Brandt, Allison
AU  - Brandt A
FAU - Gao, Xing
AU  - Gao X
FAU - Lin, Margaret
AU  - Lin M
FAU - Luo, Jing
AU  - Luo J
FAU - Song, Philip
AU  - Song P
FAU - Sun, Kai
AU  - Sun K
FAU - Zhang, Xiaoxi
AU  - Zhang X
LA  - eng
PT  - Journal Article
DEP - 20110712
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - China
MH  - *Duplicate Publications as Topic
MH  - *Empirical Research
MH  - Ethics, Research
MH  - *Language
MH  - *Manuscripts as Topic
MH  - Publications/*ethics/*statistics & numerical data
MH  - Research/*statistics & numerical data
PMC - PMC3134484
EDAT- 2011/07/19 06:00
MHDA- 2011/11/10 06:00
CRDT- 2011/07/19 06:00
PHST- 2010/10/29 00:00 [received]
PHST- 2011/06/18 00:00 [accepted]
PHST- 2011/07/19 06:00 [entrez]
PHST- 2011/07/19 06:00 [pubmed]
PHST- 2011/11/10 06:00 [medline]
AID - 10.1371/journal.pone.0022149 [doi]
AID - PONE-D-10-04237 [pii]
PST - ppublish
SO  - PLoS One. 2011;6(7):e22149. doi: 10.1371/journal.pone.0022149. Epub 2011 Jul 12.


PMID- 21764861
OWN - NLM
STAT- MEDLINE
DCOM- 20111026
LR  - 20110718
IS  - 1468-960X (Electronic)
IS  - 1362-0347 (Linking)
VI  - 14
IP  - 3
DP  - 2011 Aug
TI  - Ethics of evidence.
PG  - 62
LID - 10.1136/ebmh.14.3.62 [doi]
FAU - Towl, Graham J
AU  - Towl GJ
LA  - eng
PT  - Editorial
PL  - England
TA  - Evid Based Ment Health
JT  - Evidence-based mental health
JID - 100883413
SB  - IM
MH  - Evidence-Based Medicine/*ethics
MH  - Humans
MH  - *Mental Health
EDAT- 2011/07/19 06:00
MHDA- 2011/10/27 06:00
CRDT- 2011/07/19 06:00
PHST- 2011/07/19 06:00 [entrez]
PHST- 2011/07/19 06:00 [pubmed]
PHST- 2011/10/27 06:00 [medline]
AID - ebmh.14.3.62 [pii]
AID - 10.1136/ebmh.14.3.62 [doi]
PST - ppublish
SO  - Evid Based Ment Health. 2011 Aug;14(3):62. doi: 10.1136/ebmh.14.3.62.


PMID- 21764823
OWN - NLM
STAT- MEDLINE
DCOM- 20120724
LR  - 20161125
IS  - 1743-0593 (Electronic)
IS  - 1743-0585 (Linking)
VI  - 97
IP  - 2
DP  - 2012 Apr
TI  - Medical management of acute severe anorexia nervosa.
PG  - 48-54
LID - 10.1136/adc.2010.199885 [doi]
AB  - Anorexia nervosa (AN) is a common condition affecting young people. The medical
      management of AN on a general paediatric ward is challenging. It is important to 
      identify young people who are at risk of medical complications, so early
      intervention can be instigated. This article aims to review the clinical practice
      and evidence supporting the current medical management of young people with AN.
      It provides a system-based approach to potential complications of the disease,
      guidance on feeding and the management of re-feeding syndrome. Approaches to
      legal and ethical challenges are also considered. While the importance of
      psychiatric treatment is recognised, the same is not discussed within this
      article.
FAU - Norrington, Amy
AU  - Norrington A
AD  - Anaesthetics and Critical Care, James Cook University Hospital, Middlesbrough,
      UK.
FAU - Stanley, Ruth
AU  - Stanley R
FAU - Tremlett, Michael
AU  - Tremlett M
FAU - Birrell, Ginny
AU  - Birrell G
LA  - eng
PT  - Journal Article
DEP - 20110715
PL  - England
TA  - Arch Dis Child Educ Pract Ed
JT  - Archives of disease in childhood. Education and practice edition
JID - 101220684
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adolescent Health Services/legislation & jurisprudence/*standards
MH  - Anorexia Nervosa/*diet therapy/epidemiology
MH  - Coercion
MH  - Humans
MH  - Informed Consent By Minors/legislation & jurisprudence
MH  - Malnutrition/drug therapy
MH  - Parents
MH  - Practice Guidelines as Topic
MH  - Psychology, Adolescent
MH  - Refeeding Syndrome/epidemiology/*prevention & control
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - United Kingdom
EDAT- 2011/07/19 06:00
MHDA- 2012/07/25 06:00
CRDT- 2011/07/19 06:00
PHST- 2011/07/19 06:00 [entrez]
PHST- 2011/07/19 06:00 [pubmed]
PHST- 2012/07/25 06:00 [medline]
AID - adc.2010.199885 [pii]
AID - 10.1136/adc.2010.199885 [doi]
PST - ppublish
SO  - Arch Dis Child Educ Pract Ed. 2012 Apr;97(2):48-54. doi: 10.1136/adc.2010.199885.
      Epub 2011 Jul 15.


PMID- 21764767
OWN - NLM
STAT- MEDLINE
DCOM- 20111206
LR  - 20110718
IS  - 1525-1489 (Electronic)
IS  - 0885-0666 (Linking)
VI  - 26
IP  - 4
DP  - 2011 Jul-Aug
TI  - Protecting participants of clinical trials conducted in the intensive care unit.
PG  - 237-49
LID - 10.1177/0885066610390867 [doi]
AB  - Research in the intensive care unit (ICU) raises a number of scientific and
      ethical challenges. Potential participants in critical care studies are likely to
      be considered particularly vulnerable-they may lack sufficient capacity to make
      informed decisions about trial participation, their health care proxies may lack 
      legal authority to enroll them in research trials or may not know their true
      intent, and the life-threatening nature of the illness may make them or their
      surrogates more susceptible to therapeutic misconception. Because of this,
      critical care investigators must exercise extreme caution when designing and
      conducting studies in the ICU. In this article, we review the key literature
      addressing the various scientific and ethical issues raised by critical care
      research, including questions of equipoise and the selection of control groups,
      informed consent, therapeutic misconception, conflict of interest, and quality
      improvement projects. We also describe the current status of key policy or
      regulatory initiatives designed to address these issues, particularly in light of
      recent controversies involving critical care studies like the ARDSNet trial.
FAU - Flanagan, Brigid M
AU  - Flanagan BM
AD  - Fresenius Medical Care North America, Waltham, MA, USA.
FAU - Philpott, Sean
AU  - Philpott S
FAU - Strosberg, Martin A
AU  - Strosberg MA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Intensive Care Med
JT  - Journal of intensive care medicine
JID - 8610344
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Clinical Trials as Topic/*ethics/methods
MH  - Conflict of Interest
MH  - Decision Making
MH  - *Ethics, Research
MH  - Humans
MH  - *Informed Consent
MH  - *Intensive Care Units
MH  - *Patient Participation
MH  - Therapeutic Equipoise
EDAT- 2011/07/19 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/19 06:00
PHST- 2011/07/19 06:00 [entrez]
PHST- 2011/07/19 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 0885066610390867 [pii]
AID - 10.1177/0885066610390867 [doi]
PST - ppublish
SO  - J Intensive Care Med. 2011 Jul-Aug;26(4):237-49. doi: 10.1177/0885066610390867.


PMID- 21764740
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20220310
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Linking)
VI  - 333
IP  - 6040
DP  - 2011 Jul 15
TI  - Trophic downgrading of planet Earth.
PG  - 301-6
LID - 10.1126/science.1205106 [doi]
AB  - Until recently, large apex consumers were ubiquitous across the globe and had
      been for millions of years. The loss of these animals may be humankind's most
      pervasive influence on nature. Although such losses are widely viewed as an
      ethical and aesthetic problem, recent research reveals extensive cascading
      effects of their disappearance in marine, terrestrial, and freshwater ecosystems 
      worldwide. This empirical work supports long-standing theory about the role of
      top-down forcing in ecosystems but also highlights the unanticipated impacts of
      trophic cascades on processes as diverse as the dynamics of disease, wildfire,
      carbon sequestration, invasive species, and biogeochemical cycles. These findings
      emphasize the urgent need for interdisciplinary research to forecast the effects 
      of trophic downgrading on process, function, and resilience in global ecosystems.
FAU - Estes, James A
AU  - Estes JA
AD  - Department of Ecology and Evolutionary Biology, University of California, Santa
      Cruz, CA 95060, USA. jestes@ucsc.edu
FAU - Terborgh, John
AU  - Terborgh J
FAU - Brashares, Justin S
AU  - Brashares JS
FAU - Power, Mary E
AU  - Power ME
FAU - Berger, Joel
AU  - Berger J
FAU - Bond, William J
AU  - Bond WJ
FAU - Carpenter, Stephen R
AU  - Carpenter SR
FAU - Essington, Timothy E
AU  - Essington TE
FAU - Holt, Robert D
AU  - Holt RD
FAU - Jackson, Jeremy B C
AU  - Jackson JB
FAU - Marquis, Robert J
AU  - Marquis RJ
FAU - Oksanen, Lauri
AU  - Oksanen L
FAU - Oksanen, Tarja
AU  - Oksanen T
FAU - Paine, Robert T
AU  - Paine RT
FAU - Pikitch, Ellen K
AU  - Pikitch EK
FAU - Ripple, William J
AU  - Ripple WJ
FAU - Sandin, Stuart A
AU  - Sandin SA
FAU - Scheffer, Marten
AU  - Scheffer M
FAU - Schoener, Thomas W
AU  - Schoener TW
FAU - Shurin, Jonathan B
AU  - Shurin JB
FAU - Sinclair, Anthony R E
AU  - Sinclair AR
FAU - Soule, Michael E
AU  - Soule ME
FAU - Virtanen, Risto
AU  - Virtanen R
FAU - Wardle, David A
AU  - Wardle DA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
SB  - IM
CIN - Science. 2011 Aug 26;333(6046):1092-3. PMID: 21868651
CIN - Science. 2011 Aug 26;333(6046):1092. PMID: 21868652
MH  - Animals
MH  - Biodiversity
MH  - *Ecosystem
MH  - *Extinction, Biological
MH  - Feeding Behavior
MH  - *Food Chain
MH  - Humans
MH  - Introduced Species
MH  - Population Dynamics
MH  - Predatory Behavior
EDAT- 2011/07/19 06:00
MHDA- 2011/07/27 06:00
CRDT- 2011/07/19 06:00
PHST- 2011/07/19 06:00 [entrez]
PHST- 2011/07/19 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
AID - 333/6040/301 [pii]
AID - 10.1126/science.1205106 [doi]
PST - ppublish
SO  - Science. 2011 Jul 15;333(6040):301-6. doi: 10.1126/science.1205106.


PMID- 21764191
OWN - NLM
STAT- MEDLINE
DCOM- 20120215
LR  - 20111031
IS  - 1532-1681 (Electronic)
IS  - 0268-960X (Linking)
VI  - 25
IP  - 6
DP  - 2011 Nov
TI  - Milestones in umbilical cord blood transplantation.
PG  - 255-9
LID - 10.1016/j.blre.2011.06.003 [doi]
AB  - Since the first human cord blood transplant, performed in 1988, cord blood banks 
      have been established worldwide for collection and cryopreservation of cord blood
      for allogeneic hematopoietic stem cell transplant. Umbilical cord blood (UCB) has
      now become one of the most commonly used source of hematopoietic stem cells for
      allogeneic transplantation. Today a global network of cord blood banks and
      transplant centers has been established for a common inventory with an estimated 
      600,000 UCB have been banked and more than 20,000 UCB units distributed worldwide
      for adults and children with severe hematological diseases. Several studies have 
      shown that the number of cells is the most important factor for engraftment while
      some degree of HLA mismatches is acceptable. The absence of ethical concern, and 
      the unlimited supply of cells explain the increasing interest of using cord blood
      for developing regenerative medicine.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Gluckman, E
AU  - Gluckman E
AD  - Eurocord, Assistance publique des hopitaux de Paris (APHP), Institut
      universitaire d'Hematologie (IUH) Hospital Saint Louis Paris, France.
      eliane.gluckman@sls.aphp.fr
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Review
DEP - 20110720
PL  - England
TA  - Blood Rev
JT  - Blood reviews
JID - 8708558
SB  - IM
MH  - Animals
MH  - Blood Banks/history/methods
MH  - Cord Blood Stem Cell Transplantation/history/methods
MH  - Fetal Blood/*transplantation
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
EDAT- 2011/07/19 06:00
MHDA- 2012/02/16 06:00
CRDT- 2011/07/19 06:00
PHST- 2011/07/19 06:00 [entrez]
PHST- 2011/07/19 06:00 [pubmed]
PHST- 2012/02/16 06:00 [medline]
AID - S0268-960X(11)00051-8 [pii]
AID - 10.1016/j.blre.2011.06.003 [doi]
PST - ppublish
SO  - Blood Rev. 2011 Nov;25(6):255-9. doi: 10.1016/j.blre.2011.06.003. Epub 2011 Jul
      20.


PMID- 21764163
OWN - NLM
STAT- MEDLINE
DCOM- 20120627
LR  - 20220309
IS  - 1879-3096 (Electronic)
IS  - 0167-7799 (Linking)
VI  - 30
IP  - 1
DP  - 2012 Jan
TI  - Advances and perspectives in in vitro human gut fermentation modeling.
PG  - 17-25
LID - 10.1016/j.tibtech.2011.06.011 [doi]
AB  - The gut microbiota is a highly specialized organ containing host-specific
      assemblages of microbes whereby metabolic activity directly impacts human health 
      and disease. In vitro gut fermentation models present an unmatched opportunity of
      performing studies frequently challenged in humans and animals owing to ethical
      concerns. Multidisciplinary systems biology analyses supported by '-omics'
      platforms remain widely neglected in the field of in vitro gut fermentation
      modeling but are key to advancing the significance of these models. Model-driven 
      experimentation using a combination of in vitro gut fermentation and in vitro
      human cell models represent an advanced approach in identifying complex
      host-microbe interactions and niches central to gut fermentation processes. The
      aim of this review is to highlight the advances and challenges exhibited by in
      vitro human gut fermentation modeling.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Payne, Amanda N
AU  - Payne AN
AD  - Institute of Food, Nutrition and Health, ETH Zurich, Zurich, Switzerland.
FAU - Zihler, Annina
AU  - Zihler A
FAU - Chassard, Christophe
AU  - Chassard C
FAU - Lacroix, Christophe
AU  - Lacroix C
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110720
PL  - England
TA  - Trends Biotechnol
JT  - Trends in biotechnology
JID - 8310903
SB  - IM
MH  - Fermentation
MH  - Gastrointestinal Tract/*microbiology
MH  - *Metagenome
MH  - *Models, Biological
EDAT- 2011/07/19 06:00
MHDA- 2012/06/28 06:00
CRDT- 2011/07/19 06:00
PHST- 2011/02/09 00:00 [received]
PHST- 2011/04/19 00:00 [revised]
PHST- 2011/06/15 00:00 [accepted]
PHST- 2011/07/19 06:00 [entrez]
PHST- 2011/07/19 06:00 [pubmed]
PHST- 2012/06/28 06:00 [medline]
AID - S0167-7799(11)00115-6 [pii]
AID - 10.1016/j.tibtech.2011.06.011 [doi]
PST - ppublish
SO  - Trends Biotechnol. 2012 Jan;30(1):17-25. doi: 10.1016/j.tibtech.2011.06.011. Epub
      2011 Jul 20.


PMID- 21764010
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20110718
IS  - 1532-1916 (Electronic)
IS  - 1521-6918 (Linking)
VI  - 25
IP  - 3
DP  - 2011 Jun
TI  - Quality assurance in gastroenterology: QA in research, and research in QA.
PG  - 427-34
LID - 10.1016/j.bpg.2011.05.006 [doi]
AB  - There is no clear distinction between research and quality assurance (QA). Both
      entities should be of high quality to serve as trustworthy tools for continuous
      evidence-based improvements in health care. Both research and QA should be of
      interest to an audience of readers of medical science - provided that the work is
      up to standards. Quality in research encompasses issues actually dealt with (are 
      we putting our resources into the right things), validity (are the findings valid
      for other than the patients tested), ethics (why should patients consent to
      studies that have no prospect of giving an answer to the questions put in the
      research protocol) - in addition to quality of design and presentation. Likewise,
      QA work could gain much on a stronger focus on research methods - as suggested in
      the upcoming Competetitive Effectiveness Research. In conclusion, quality in
      research and research in QA should be asked and requested more often.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Hoff, Geir
AU  - Hoff G
AD  - Telemark Hospital, Skien, Norway.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Best Pract Res Clin Gastroenterol
JT  - Best practice & research. Clinical gastroenterology
JID - 101120605
SB  - IM
MH  - Biomedical Research/*standards
MH  - Gastroenterology/*standards
MH  - Humans
MH  - Quality Assurance, Health Care/*standards
EDAT- 2011/07/19 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/19 06:00
PHST- 2011/03/27 00:00 [received]
PHST- 2011/05/16 00:00 [accepted]
PHST- 2011/07/19 06:00 [entrez]
PHST- 2011/07/19 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S1521-6918(11)00058-8 [pii]
AID - 10.1016/j.bpg.2011.05.006 [doi]
PST - ppublish
SO  - Best Pract Res Clin Gastroenterol. 2011 Jun;25(3):427-34. doi:
      10.1016/j.bpg.2011.05.006.


PMID- 21763528
OWN - NLM
STAT- MEDLINE
DCOM- 20111114
LR  - 20110718
IS  - 1875-7855 (Electronic)
IS  - 0079-6123 (Linking)
VI  - 192
DP  - 2011
TI  - Real-time functional magnetic imaging-brain-computer interface and virtual
      reality promising tools for the treatment of pedophilia.
PG  - 263-72
LID - 10.1016/B978-0-444-53355-5.00014-2 [doi]
AB  - This chapter proposes a prospective view on using a real-time functional magnetic
      imaging (rt-fMRI) brain-computer interface (BCI) application as a new treatment
      for pedophilia. Neurofeedback mediated by interactive virtual stimuli is
      presented as the key process in this new BCI application. Results on the
      diagnostic discriminant power of virtual characters depicting sexual stimuli
      relevant to pedophilia are given. Finally, practical and ethical implications are
      briefly addressed.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Renaud, Patrice
AU  - Renaud P
AD  - Universite du Quebec en Outaouais, Institut Philippe-Pinel de Montreal, Montreal,
      Quebec, Canada. patrice.renaud@uqo.ca
FAU - Joyal, Christian
AU  - Joyal C
FAU - Stoleru, Serge
AU  - Stoleru S
FAU - Goyette, Mathieu
AU  - Goyette M
FAU - Weiskopf, Nikolaus
AU  - Weiskopf N
FAU - Birbaumer, Niels
AU  - Birbaumer N
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Prog Brain Res
JT  - Progress in brain research
JID - 0376441
SB  - IM
MH  - Brain Mapping/*methods
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Neurofeedback/physiology
MH  - Pedophilia/physiopathology/*therapy
MH  - Plethysmography/methods
MH  - ROC Curve
MH  - Time Factors
MH  - *User-Computer Interface
EDAT- 2011/07/19 06:00
MHDA- 2011/11/15 06:00
CRDT- 2011/07/19 06:00
PHST- 2011/07/19 06:00 [entrez]
PHST- 2011/07/19 06:00 [pubmed]
PHST- 2011/11/15 06:00 [medline]
AID - B978-0-444-53355-5.00014-2 [pii]
AID - 10.1016/B978-0-444-53355-5.00014-2 [doi]
PST - ppublish
SO  - Prog Brain Res. 2011;192:263-72. doi: 10.1016/B978-0-444-53355-5.00014-2.


PMID- 21762781
OWN - NLM
STAT- MEDLINE
DCOM- 20120112
LR  - 20131121
IS  - 1879-1220 (Electronic)
IS  - 0960-0760 (Linking)
VI  - 127
IP  - 3-5
DP  - 2011 Nov
TI  - Metabolic studies with promagnon, methylclostebol and methasterone in the
      uPA+/+-SCID chimeric mice.
PG  - 374-81
LID - 10.1016/j.jsbmb.2011.06.010 [doi]
AB  - The chimeric uPA(+/+)-SCID mouse model, transplanted with human hepatocytes, was 
      previously validated as an alternative tool to study in vivo the human steroid
      metabolism. This humanized mouse model was now applied, in the framework of
      anti-doping research, to test different nutritional supplements containing
      steroids. These steroids, intentionally or accidentally added to a nutritional
      supplement, usually are derivatives of testosterone. Information about the
      metabolism of these derivatives, which is important to assure their detection, is
      quite limited. However, due to ethical constraints, human volunteers cannot be
      used to perform experimental excretion studies. Therefore the chimeric mice were 
      selected to perform three separated excretion studies with superdrol
      (methasterone), promagnon and also methylclostebol. The urine of the humanized
      mice was collected 24h after a single dose administration and analyzed by gas
      chromatography-mass spectrometry (GC-MS). The results indicated the presence of
      several metabolites including a 3-keto reduced metabolite and numerous
      hydroxylated metabolites. Also phase 2 metabolism was investigated to update the 
      complete picture of their metabolism.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Lootens, L
AU  - Lootens L
AD  - Doping Control Laboratory, Department of Clinical Biology, Ghent University,
      Technologiepark 30, 9052 Zwijnaarde, Belgium. leen.lootens@ugent.be
FAU - Meuleman, P
AU  - Meuleman P
FAU - Leroux-Roels, G
AU  - Leroux-Roels G
FAU - Van Eenoo, P
AU  - Van Eenoo P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110705
PL  - England
TA  - J Steroid Biochem Mol Biol
JT  - The Journal of steroid biochemistry and molecular biology
JID - 9015483
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Animals
MH  - Cholesterol/*metabolism
MH  - Mice
MH  - Mice, SCID
EDAT- 2011/07/19 06:00
MHDA- 2012/01/13 06:00
CRDT- 2011/07/19 06:00
PHST- 2011/01/26 00:00 [received]
PHST- 2011/06/06 00:00 [revised]
PHST- 2011/06/25 00:00 [accepted]
PHST- 2011/07/19 06:00 [entrez]
PHST- 2011/07/19 06:00 [pubmed]
PHST- 2012/01/13 06:00 [medline]
AID - S0960-0760(11)00144-0 [pii]
AID - 10.1016/j.jsbmb.2011.06.010 [doi]
PST - ppublish
SO  - J Steroid Biochem Mol Biol. 2011 Nov;127(3-5):374-81. doi:
      10.1016/j.jsbmb.2011.06.010. Epub 2011 Jul 5.


PMID- 21762776
OWN - NLM
STAT- MEDLINE
DCOM- 20120413
LR  - 20191210
IS  - 1879-3177 (Electronic)
IS  - 0887-2333 (Linking)
VI  - 25
IP  - 8
DP  - 2011 Dec
TI  - Human scalp permeability to the chemical warfare agent VX.
PG  - 1974-80
LID - 10.1016/j.tiv.2011.06.021 [doi]
AB  - The use of chemical warfare agents such as VX in terrorism act might lead to
      contamination of the civilian population. Human scalp decontamination may require
      appropriate products and procedures. Due to ethical reasons, skin decontamination
      studies usually involve in vitro skin models, but human scalp skin samples are
      uncommon and expensive. The purpose of this study was to characterize the in
      vitro permeability to VX of human scalp, and to compare it with (a) human
      abdominal skin, and (b) pig skin from two different anatomic sites: ear and skull
      roof, in order to design a relevant model. Based on the VX skin permeation
      kinetics and distribution, we demonstrated that (a) human scalp was significantly
      more permeable to VX than abdominal skin and (b) pig-ear skin was the most
      relevant model to predict the in vitro human scalp permeability. Our results
      indicated that the follicular pathway significantly contributed to the skin
      absorption of VX through human scalp. In addition, the hair follicles and the
      stratum corneum significantly contributed to the formation of a skin reservoir
      for VX.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Rolland, P
AU  - Rolland P
AD  - Universite de Lyon, F-69622 Lyon, France. rolland@lagep.univ-lyon1.fr
FAU - Bolzinger, M-A
AU  - Bolzinger MA
FAU - Cruz, C
AU  - Cruz C
FAU - Briancon, S
AU  - Briancon S
FAU - Josse, D
AU  - Josse D
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110706
PL  - England
TA  - Toxicol In Vitro
JT  - Toxicology in vitro : an international journal published in association with
      BIBRA
JID - 8712158
RN  - 0 (Chemical Warfare Agents)
RN  - 0 (Organothiophosphorus Compounds)
RN  - 9A4381183B (VX)
SB  - IM
MH  - Abdomen
MH  - Adult
MH  - Animals
MH  - Chemical Warfare Agents/*metabolism
MH  - Ear
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Models, Animal
MH  - Organothiophosphorus Compounds/*metabolism
MH  - Permeability
MH  - *Scalp
MH  - Skin/metabolism
MH  - *Skin Absorption
MH  - Skull
MH  - *Swine
MH  - Young Adult
EDAT- 2011/07/19 06:00
MHDA- 2012/04/14 06:00
CRDT- 2011/07/19 06:00
PHST- 2011/03/10 00:00 [received]
PHST- 2011/06/16 00:00 [revised]
PHST- 2011/06/29 00:00 [accepted]
PHST- 2011/07/19 06:00 [entrez]
PHST- 2011/07/19 06:00 [pubmed]
PHST- 2012/04/14 06:00 [medline]
AID - S0887-2333(11)00189-5 [pii]
AID - 10.1016/j.tiv.2011.06.021 [doi]
PST - ppublish
SO  - Toxicol In Vitro. 2011 Dec;25(8):1974-80. doi: 10.1016/j.tiv.2011.06.021. Epub
      2011 Jul 6.


PMID- 21762493
OWN - NLM
STAT- MEDLINE
DCOM- 20111209
LR  - 20211020
IS  - 1471-230X (Electronic)
IS  - 1471-230X (Linking)
VI  - 11
DP  - 2011 Jul 15
TI  - To compare the efficacy of two kinds of Zhizhu pills in the treatment of
      functional dyspepsia of spleen-deficiency and qi-stagnation syndrome: a
      randomized group sequential comparative trial.
PG  - 81
LID - 10.1186/1471-230X-11-81 [doi]
AB  - BACKGROUND: In Traditional Chinese Medicine (TCM) theory, functional dyspepsia
      (FD) can be divided into different syndromes according to different clinical
      symptoms and signs, and the most common one is spleen-deficiency and
      qi-stagnation syndrome that can be treated by Chinese traditional patent
      medicine--two kinds of Zhizhu pills, between which the primary difference in
      ingredients is that one contains immature orange fruit of Citrus aurantium
      L.(IFCA) and the other contains that of Citrus sinensis Osbeck (IFCS). The
      trial's objective was to compare the efficacy of two kinds of Zhizhu pills on
      symptom changes in patients with FD of spleen-deficiency and qi-stagnation
      syndrome. METHODS: A randomized, group sequential, double-blinded, multicenter
      trial was conducted in patients with FD of spleen-deficiency and qi-stagnation
      syndrome at 3 hospitals in Beijing between June 2003 and May 2005. Participants
      were randomly allocated into two groups (IFCA group and IFCS group) in a 1:1
      ratio, and respectively took one of the two kinds of Zhizhu pills orally, 6 g
      each time, 3 times a day, for 4 weeks. Statistical analysis was performed with
      use of a group sequential method, the triangular test (TT). RESULTS: A total of
      163 patients were randomized, and 3 patients were excluded from analysis because 
      of early dropouts, leaving 160 patients (IFCA group: n = 82; IFCS group: n = 78) 
      for statistical analysis. Three interim analyses were done after 62, 116, and 160
      patients had completed their 4-week treatment, respectively. At the third interim
      analysis, the sample path crossed the upper boundary and the trial was stopped,
      the cure-markedly effective rates were 45% for IFCS group and 67% for IFCA group,
      respectively, the one-sided p-value was 0.0036, the median unbiased estimate of
      the odds ratio (OR) for the benefit of IFCA relative to IFCS was 2.91 with 95%CI:
      1.40 to 6.06.No adverse events were observed in the two groups. CONCLUSIONS:
      Zhizhu pills containing IFCA was superior to Zhizhu pills containing IFCS in the 
      treatment of FD of spleen-deficiency and qi-stagnation syndrome. The application 
      of group sequential analysis in clinical trials of TCM may offer some financial
      and ethical benefits. TRIAL REGISTRATION: Chinese Clinical Trial Registry
      (ChiCTR): ChiCTR-TRC-00000485.
FAU - Wu, Hongli
AU  - Wu H
AD  - Institute of Basic Research in Clinical Medicine, China Academy of Chinese
      Medical Sciences, No. 16 Nanxiaojie, Dongzhimen nei, Beijing, 100700, China.
FAU - Jing, Zhiwei
AU  - Jing Z
FAU - Tang, Xudong
AU  - Tang X
FAU - Wang, Xinyue
AU  - Wang X
FAU - Zhang, Shengsheng
AU  - Zhang S
FAU - Yu, Yanan
AU  - Yu Y
FAU - Wang, Zhong
AU  - Wang Z
FAU - Cao, Hongxin
AU  - Cao H
FAU - Huang, Luqi
AU  - Huang L
FAU - Yu, Youhua
AU  - Yu Y
FAU - Wang, Yongyan
AU  - Wang Y
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110715
PL  - England
TA  - BMC Gastroenterol
JT  - BMC gastroenterology
JID - 100968547
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Tablets)
SB  - IM
MH  - Adult
MH  - *Citrus
MH  - *Citrus sinensis
MH  - Double-Blind Method
MH  - Drugs, Chinese Herbal/*therapeutic use
MH  - Dyspepsia/*drug therapy/pathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Phytotherapy
MH  - Qi
MH  - Splenic Diseases/*drug therapy/pathology
MH  - Syndrome
MH  - Tablets
MH  - Treatment Outcome
PMC - PMC3160401
EDAT- 2011/07/19 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/07/19 06:00
PHST- 2009/12/21 00:00 [received]
PHST- 2011/07/15 00:00 [accepted]
PHST- 2011/07/19 06:00 [entrez]
PHST- 2011/07/19 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 1471-230X-11-81 [pii]
AID - 10.1186/1471-230X-11-81 [doi]
PST - epublish
SO  - BMC Gastroenterol. 2011 Jul 15;11:81. doi: 10.1186/1471-230X-11-81.


PMID- 21762419
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20220318
IS  - 1365-2702 (Electronic)
IS  - 0962-1067 (Linking)
VI  - 20
IP  - 17-18
DP  - 2011 Sep
TI  - Good care in group home living for people with dementia. Experiences of
      residents, family and nursing staff.
PG  - 2490-500
LID - 10.1111/j.1365-2702.2011.03759.x [doi]
AB  - AIMS AND OBJECTIVES: To investigate experiences of residents, their family
      caregivers and nursing staff in group living homes for older people with dementia
      and their perception of the care process. BACKGROUND: Traditional nursing homes
      for people with dementia have several shortcomings related to depersonalisation, 
      passivity, loss of skills and use of physical restraints. Group living homes are 
      seen as an alternative to regular nursing homes, but experiences with this new
      care setting have rarely been investigated. DESIGN: The study followed a
      naturalistic design. Qualitative data were collected over a period of 6 months in
      two group living homes located in the southern part of the Netherlands. METHODS: 
      Systematic participatory observations were carried out during daily life, care
      and activities in both homes. In addition, semi-structured interviews were held
      with residents, their family and nursing staff. These data were inductively
      analysed and related to Tronto's care ethical framework. RESULTS: According to
      all parties, group living homes create structural opportunities for
      individualised care and attention to the residents' personal needs. The increased
      attentiveness and responsiveness for residents' well-being was seen as a sign of 
      good care and fits with the phases of caring about and receiving care of Tronto's
      care ethical model. However, tensions occurred relating to the phases of taking
      responsibility and carrying out care. Not all residents and family members want
      or are able to take responsibility and perform self-care. CONCLUSIONS: Group
      living homes create conditions for good care and stimulate attentiveness and
      responsiveness. Tensions in these homes may relate to the new division of
      responsibilities and tasks. RELEVANCE TO CLINICAL PRACTICE: Values of attention
      to needs and responsiveness are of high importance for nursing staff to provide
      good care for people with dementia in a nursing home setting.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - van Zadelhoff, Ezra
AU  - van Zadelhoff E
AD  - Faculty of Health, Medicine and Life Sciences, Department of Health Services
      Research, School for Public Health and Primary Care CAPHRI, Maastricht
      University, Amsterdam, The Netherlands. e.vanzadelhoff@maastrichtuniversity.nl
FAU - Verbeek, Hilde
AU  - Verbeek H
FAU - Widdershoven, Guy
AU  - Widdershoven G
FAU - van Rossum, Erik
AU  - van Rossum E
FAU - Abma, Tineke
AU  - Abma T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110718
PL  - England
TA  - J Clin Nurs
JT  - Journal of clinical nursing
JID - 9207302
MH  - Aged
MH  - Aged, 80 and over
MH  - Dementia/*nursing
MH  - Family/*psychology
MH  - Group Homes/*standards
MH  - Humans
MH  - Inpatients/*psychology
MH  - Netherlands
MH  - Nursing Staff/*psychology
EDAT- 2011/07/19 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/19 06:00
PHST- 2011/07/19 06:00 [entrez]
PHST- 2011/07/19 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1111/j.1365-2702.2011.03759.x [doi]
PST - ppublish
SO  - J Clin Nurs. 2011 Sep;20(17-18):2490-500. doi: 10.1111/j.1365-2702.2011.03759.x. 
      Epub 2011 Jul 18.


PMID- 21762341
OWN - NLM
STAT- MEDLINE
DCOM- 20120524
LR  - 20181201
IS  - 1445-5994 (Electronic)
IS  - 1444-0903 (Linking)
VI  - 41
IP  - 7
DP  - 2011 Jul
TI  - 2007 National Statement on Ethical Conduct in Human Research.
PG  - 581-2
LID - 10.1111/j.1445-5994.2011.02528.x [doi]
FAU - Anderson, W
AU  - Anderson W
LA  - eng
PT  - Letter
PT  - Comment
PL  - Australia
TA  - Intern Med J
JT  - Internal medicine journal
JID - 101092952
SB  - IM
CON - Intern Med J. 2011 Jan;41(1a):73. PMID: 21265969
MH  - *Ethics Committees, Research
MH  - *Guidelines as Topic
MH  - Human Experimentation/*ethics
MH  - Humans
EDAT- 2011/07/19 06:00
MHDA- 2012/05/25 06:00
CRDT- 2011/07/19 06:00
PHST- 2011/07/19 06:00 [entrez]
PHST- 2011/07/19 06:00 [pubmed]
PHST- 2012/05/25 06:00 [medline]
AID - 10.1111/j.1445-5994.2011.02528.x [doi]
PST - ppublish
SO  - Intern Med J. 2011 Jul;41(7):581-2. doi: 10.1111/j.1445-5994.2011.02528.x.


PMID- 21762308
OWN - NLM
STAT- MEDLINE
DCOM- 20111223
LR  - 20120322
IS  - 1742-1241 (Electronic)
IS  - 1368-5031 (Linking)
VI  - 65
IP  - 8
DP  - 2011 Aug
TI  - Heart failure in pregnancy: an overview.
PG  - 848-51
LID - 10.1111/j.1742-1241.2011.02714.x [doi]
AB  - The treatment of heart failure in pregnant women is more difficult than in
      non-pregnant women, and should always involve a multidisciplinary team approach. 
      Knowledge required includes hemodynamic changes in pregnancy and the resultant
      effect on women with pre-existing or pregnancy-related cardiovascular disease,
      cardiovascular drugs in pregnancy, ethical issues and challenges regarding saving
      mother and baby. In addition, women having high risk cardiac lesions should be
      counselled strongly against pregnancy and followed up regularly. Pregnancy with
      heart failure is an important issue, demanding more comprehensive studies.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Ahmad, W A Wan
AU  - Ahmad WA
AD  - Division of Cardiology, University Malaya Medical Center, Kuala Lumpur, Malaysia.
      wanazman@ummc.edu.my
FAU - Khanom, M
AU  - Khanom M
FAU - Yaakob, Z H
AU  - Yaakob ZH
LA  - eng
PT  - Journal Article
PT  - Review
PL  - India
TA  - Int J Clin Pract
JT  - International journal of clinical practice
JID - 9712381
SB  - IM
CIN - Int J Clin Pract. 2012 Mar;66(3):328. PMID: 22340455
MH  - Counseling/methods
MH  - Delivery, Obstetric/methods
MH  - Early Diagnosis
MH  - Female
MH  - Heart Failure/diagnosis/physiopathology/*therapy
MH  - Hemodynamics
MH  - Humans
MH  - Postnatal Care/methods
MH  - Preconception Care/methods
MH  - Pregnancy
MH  - Pregnancy Complications, Cardiovascular/diagnosis/physiopathology/*therapy
MH  - Pregnancy Outcome
MH  - Prenatal Care/methods
MH  - Prenatal Diagnosis/methods
MH  - Risk Assessment
MH  - Risk Factors
EDAT- 2011/07/19 06:00
MHDA- 2011/12/24 06:00
CRDT- 2011/07/19 06:00
PHST- 2011/07/19 06:00 [entrez]
PHST- 2011/07/19 06:00 [pubmed]
PHST- 2011/12/24 06:00 [medline]
AID - 10.1111/j.1742-1241.2011.02714.x [doi]
PST - ppublish
SO  - Int J Clin Pract. 2011 Aug;65(8):848-51. doi: 10.1111/j.1742-1241.2011.02714.x.


PMID- 21761573
OWN - NLM
STAT- MEDLINE
DCOM- 20121017
LR  - 20151119
IS  - 1932-7005 (Electronic)
IS  - 1932-6254 (Linking)
VI  - 6
IP  - 6
DP  - 2012 Jun
TI  - Expansion and long-term maintenance of induced pluripotent stem cells in stirred 
      suspension bioreactors.
PG  - 462-72
LID - 10.1002/term.450 [doi]
AB  - Induced pluripotent stem cells (iPSCs) can provide an important source of cells
      for the next-generation of cell therapies in regenerative medicine, in part due
      to their similarity to embryonic stem cells (ESCs). Patient-specific iPSCs
      represent an opportunity for autologous cell therapies that are not restricted by
      immunological, ethical and technical obstacles. One of the technical hurdles that
      must be overcome before iPSCs can be clinically implemented is the scalable,
      reproducible production of iPSCs and their differentiated progeny. All of the
      iPSC lines established thus far have been generated and expanded with static
      tissue culture protocols, which are time-consuming and suffer from batch-to-batch
      variability. Alternatively, stirred suspension bioreactors propose several
      benefits and their homogeneous culture environment facilitates the large-scale
      expansion required for clinical studies at less cost. We have previously
      developed protocols for expanding murine and human ESCs as undifferentiated
      aggregates in stirred suspension bioreactors. The resulting cells were
      karyotypically normal, expressed pluripotency markers and could be differentiated
      into all three germ lineages, both in vitro and in vivo. In this study, we
      demonstrate that stirred suspension bioreactors yield 58-fold expansion of
      undifferentiated pluripotent iPSCs over 4 days. In vitro differentiation into
      cartilage, bone and cardiomyocytes lineages, in addition to in vivo teratoma
      formation, further confirmed the existence of fully functional and
      undifferentiated pluripotent iPSC aggregates following long-term passaging.
      Stirred suspension bioreactor culture represents an efficient process for the
      large-scale expansion and maintenance of iPSCs, which is an important first step 
      in their clinical application.
CI  - Copyright (c) 2011 John Wiley & Sons, Ltd.
FAU - Shafa, Mehdi
AU  - Shafa M
AD  - Department of Biochemistry and Molecular Biology, University of Calgary, AB,
      Canada.
FAU - Sjonnesen, Kirsten
AU  - Sjonnesen K
FAU - Yamashita, Akihiro
AU  - Yamashita A
FAU - Liu, Shiying
AU  - Liu S
FAU - Michalak, Marek
AU  - Michalak M
FAU - Kallos, Michael S
AU  - Kallos MS
FAU - Rancourt, Derrick E
AU  - Rancourt DE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110714
PL  - England
TA  - J Tissue Eng Regen Med
JT  - Journal of tissue engineering and regenerative medicine
JID - 101308490
RN  - 0 (Biomarkers)
RN  - 0 (Suspensions)
SB  - IM
MH  - Animals
MH  - Biomarkers/metabolism
MH  - *Bioreactors
MH  - Cell Aggregation
MH  - Cell Culture Techniques/*instrumentation/*methods
MH  - Cell Differentiation
MH  - Cell Line
MH  - Cell Lineage
MH  - Cell Proliferation
MH  - Colony-Forming Units Assay
MH  - Embryoid Bodies/cytology/metabolism
MH  - Germ Layers/cytology
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*cytology/metabolism
MH  - Karyotyping
MH  - Kinetics
MH  - Mice
MH  - Mice, SCID
MH  - Suspensions
MH  - Time Factors
EDAT- 2011/07/16 06:00
MHDA- 2012/10/18 06:00
CRDT- 2011/07/16 06:00
PHST- 2010/11/20 00:00 [received]
PHST- 2011/05/12 00:00 [accepted]
PHST- 2011/07/16 06:00 [entrez]
PHST- 2011/07/16 06:00 [pubmed]
PHST- 2012/10/18 06:00 [medline]
AID - 10.1002/term.450 [doi]
PST - ppublish
SO  - J Tissue Eng Regen Med. 2012 Jun;6(6):462-72. doi: 10.1002/term.450. Epub 2011
      Jul 14.


PMID- 21761279
OWN - NLM
STAT- MEDLINE
DCOM- 20120227
LR  - 20211020
IS  - 1432-1084 (Electronic)
IS  - 0938-7994 (Linking)
VI  - 21
IP  - 12
DP  - 2011 Dec
TI  - Macromolecule content influences proton diffusibility in gliomas.
PG  - 2626-32
LID - 10.1007/s00330-011-2206-3 [doi]
AB  - OBJECTIVES: Different compositions of the extra cellular matrix with changing
      concentrations of more or less hydrophilic components like proteins may have a
      major influence on the diffusion phenomena found in gliomas. METHODS: 24 patients
      (14 male / 10 female) with histologically confirmed non necrotic glioma underwent
      preoperative MRI, including magnetisation transfer (MTR), triple echo T2 weighted
      (T2W) and diffusion weighted (DWI) sequences. Apparent diffusion coefficient
      (ADC), quantitative T2 and MTR maps were calculated and regions of interest
      (ROIs) were placed in the tumour centre (TU) and in the contralateral hemisphere 
      (NWM). Informed consent was obtained. The study was approved by the local ethic
      comity. RESULTS: Mean values evaluated in the NWM / TU were (+/- standard
      deviation); ADC: 0.78 (+/-0.08) x 10-3 mm2/s / 1.32 (+/-0.27) x 10-3 mm2/s, T2:
      101.66 (+/-12.00) ms / 252.11 (+/-104.53) ms, MTR: 0.52 (+/-0.01) / 0.40
      (+/-0.04). The mean value of each parameter correlated highly significant with
      the others (p < 0.01). CONCLUSION: Our results suggest that macromolecules
      binding protons in their vicinity are a major determinant of proton diffusivity
      in brain tumours in addition to other factors such as mechanical barriers like
      membranes or the size of the extra-cellular space.
FAU - Goebell, Einar
AU  - Goebell E
AD  - Department of Diagnostic and Interventional Neuroradiology, University Medical
      Center Hamburg-Eppendorf (UKE), Martinistrasse 52, 20246 Hamburg, Germany.
      e.goebell@uke.de
FAU - Fiehler, Jens
AU  - Fiehler J
FAU - Siemonsen, Susanne
AU  - Siemonsen S
FAU - Vaeterlein, Ole
AU  - Vaeterlein O
FAU - Heese, Oliver
AU  - Heese O
FAU - Hagel, Christian
AU  - Hagel C
FAU - Ding, Xiao-Qi
AU  - Ding XQ
FAU - Buhk, Jan-Hendrik
AU  - Buhk JH
FAU - Groth, Michael
AU  - Groth M
FAU - Kucinski, Thomas
AU  - Kucinski T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110716
PL  - Germany
TA  - Eur Radiol
JT  - European radiology
JID - 9114774
RN  - 0 (Macromolecular Substances)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brain Neoplasms/*diagnosis/genetics/pathology
MH  - Diffusion Magnetic Resonance Imaging
MH  - Female
MH  - Glioma/*diagnosis/genetics/pathology
MH  - Humans
MH  - Macromolecular Substances
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Preoperative Care
EDAT- 2011/07/16 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/07/16 06:00
PHST- 2011/03/28 00:00 [received]
PHST- 2011/06/14 00:00 [accepted]
PHST- 2011/05/29 00:00 [revised]
PHST- 2011/07/16 06:00 [entrez]
PHST- 2011/07/16 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - 10.1007/s00330-011-2206-3 [doi]
PST - ppublish
SO  - Eur Radiol. 2011 Dec;21(12):2626-32. doi: 10.1007/s00330-011-2206-3. Epub 2011
      Jul 16.


PMID- 21761244
OWN - NLM
STAT- MEDLINE
DCOM- 20131126
LR  - 20220409
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 1
DP  - 2013 Mar
TI  - Exploring why and how journal editors retract articles: findings from a
      qualitative study.
PG  - 1-11
LID - 10.1007/s11948-011-9292-0 [doi]
AB  - Editors have a responsibility to retract seriously flawed articles from their
      journals. However, there appears to be little consistency in journals' policies
      or procedures for this. In a qualitative study, we therefore interviewed editors 
      of science journals using semi-structured interviews to investigate their
      experience of retracting articles. We identified potential barriers to
      retraction, difficulties in the process and also sources of support and
      encouragement. Our findings have been used as the basis for guidelines developed 
      by the Committee on Publication Ethics.
FAU - Williams, Peter
AU  - Williams P
AD  - University College London, London, WC1E 6BT, UK. Peter.williams@ucl.ac.uk
FAU - Wager, Elizabeth
AU  - Wager E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110715
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Editorial Policies
MH  - *Ethics, Research
MH  - Guidelines as Topic
MH  - Humans
MH  - Interviews as Topic
MH  - Periodicals as Topic/*ethics
MH  - *Retraction of Publication as Topic
MH  - *Scientific Misconduct
MH  - *Social Responsibility
EDAT- 2011/07/16 06:00
MHDA- 2013/12/16 06:00
CRDT- 2011/07/16 06:00
PHST- 2011/04/07 00:00 [received]
PHST- 2011/07/05 00:00 [accepted]
PHST- 2011/07/16 06:00 [entrez]
PHST- 2011/07/16 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1007/s11948-011-9292-0 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Mar;19(1):1-11. doi: 10.1007/s11948-011-9292-0. Epub 2011
      Jul 15.


PMID- 21761243
OWN - NLM
STAT- MEDLINE
DCOM- 20131126
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 1
DP  - 2013 Mar
TI  - Engineering ethics beyond engineers' ethics.
PG  - 179-87
LID - 10.1007/s11948-011-9293-z [doi]
AB  - Engineering ethics is usually focused on engineers' ethics, engineers acting as
      individuals. Certainly, these professionals play a central role in the matter,
      but engineers are not a singularity inside engineering; they exist and operate as
      a part of a complex network of mutual relationships between many other people,
      organizations and groups. When engineering ethics and engineers' ethics are taken
      as one and the same thing the paradigm of the ethical engineer which prevails is 
      that of the heroic engineer, a certain model of the ideal engineer: someone both 
      quite individualistic and strong enough to deal with all the moral challenges
      that could arise. We argue that this is not the best approach, at least today in 
      our interrelated world. We have achieved a high degree of independence from
      nature by means of technology. In exchange for this autonomy we have become
      increasingly tied up with very complex systems to which we constantly delegate
      new tasks and powers. Concerns about safety keep growing everywhere due to the
      fact that now we have a sensitive awareness of the huge amount of power we are
      both consuming and deploying, thus, new forms of dialogue and consensus have to
      be incorporated at different levels, in different forums and at different times. 
      Within these democratic channels of participation not just the needs and
      interests, but also the responsibilities and mutual commitments of all parties
      should be taken into account.
FAU - Basart, Josep M
AU  - Basart JM
AD  - Universitat Autonoma de Barcelona, Escola d'Enginyeria, Cerdanyola del Valles,
      Catalunya, Spain. josepmaria.basart@uab.cat
FAU - Serra, Montse
AU  - Serra M
LA  - eng
PT  - Journal Article
DEP - 20110715
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Engineering/*ethics
MH  - *Ethics, Professional
MH  - Humans
MH  - *Morals
MH  - *Social Responsibility
MH  - Technology/*ethics
EDAT- 2011/07/16 06:00
MHDA- 2013/12/16 06:00
CRDT- 2011/07/16 06:00
PHST- 2011/04/15 00:00 [received]
PHST- 2011/07/05 00:00 [accepted]
PHST- 2011/07/16 06:00 [entrez]
PHST- 2011/07/16 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1007/s11948-011-9293-z [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Mar;19(1):179-87. doi: 10.1007/s11948-011-9293-z. Epub 2011 
      Jul 15.


PMID- 21761217
OWN - NLM
STAT- MEDLINE
DCOM- 20111212
LR  - 20211020
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 23
IP  - 2
DP  - 2011 Jun
TI  - Global health needs and the short-term medical volunteer: ethical considerations.
PG  - 71-8
LID - 10.1007/s10730-011-9158-5 [doi]
FAU - Langowski, Michele K
AU  - Langowski MK
AD  - Albert Gnaegi Center for Health Care Ethics, Salus Center, Saint Louis
      University, 3545 Lafayette, 5th Floor, St. Louis, MO 63104-1314, USA.
      langowmk@gmail.com
FAU - Iltis, Ana S
AU  - Iltis AS
LA  - eng
PT  - Introductory Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - *Global Health
MH  - Humans
MH  - Medical Missions/*ethics
MH  - *Volunteers
EDAT- 2011/07/16 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/07/16 06:00
PHST- 2011/07/16 06:00 [entrez]
PHST- 2011/07/16 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 10.1007/s10730-011-9158-5 [doi]
PST - ppublish
SO  - HEC Forum. 2011 Jun;23(2):71-8. doi: 10.1007/s10730-011-9158-5.


PMID- 21761206
OWN - NLM
STAT- MEDLINE
DCOM- 20120419
LR  - 20220408
IS  - 1438-8359 (Electronic)
IS  - 0913-8668 (Linking)
VI  - 25
IP  - 5
DP  - 2011 Oct
TI  - Effect of acupuncture on nausea and/or vomiting during and after cesarean section
      in comparison with ondansetron.
PG  - 698-703
LID - 10.1007/s00540-011-1198-0 [doi]
AB  - PURPOSE: Acupuncture has been used for the management of postoperative nausea and
      vomiting (PONV). This study compared the effect of electrical acustimulation with
      ondansetron for preventing intraoperative and postoperative emetic symptoms and
      improving patient satisfaction. METHODS: After gaining ethical approval, 450
      parturients scheduled for elective cesarean delivery were randomly allocated to
      receive either electrical stimulation using P6 acupoint (pericardium 6)
      bilaterally for 30 min before spinal anesthesia (group III; n = 150), or 4 mg
      ondansetron 30 min before spinal anesthesia (group II; n = 150), or placebo
      (group II; n = 150). Nausea and vomiting were evaluated and recorded
      intraoperatively and postoperative for 24 h by an independent anesthetist.
      RESULTS: The three groups were not significantly different with respect to
      intraoperative ephedrine dose and duration of surgery. Nausea and vomiting
      occurred statistically significantly less often in the active treatment groups
      (II, III) during operation and for 6 h postoperatively. There was no
      statistically significant difference between the groups in the incidence of
      nausea and vomiting from 6 to 24 h postoperatively. Patient satisfaction with
      PONV control was higher with the active treatment groups compared with group I.
      CONCLUSION: Electrical acustimulation is comparable to ondansetron in prevention 
      of PONV during and after cesarean delivery under spinal anesthesia and in
      improving patient satisfaction.
FAU - El-Deeb, Alaa M
AU  - El-Deeb AM
AD  - Department of Anesthesiology, Faculty of Medicine, Mansoura University, Mansoura,
      Egypt. Alaaeldeep9@hotmail.com
FAU - Ahmady, Mona S
AU  - Ahmady MS
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20110715
PL  - Japan
TA  - J Anesth
JT  - Journal of anesthesia
JID - 8905667
RN  - 0 (Antiemetics)
RN  - 4AF302ESOS (Ondansetron)
SB  - IM
MH  - Acupuncture Therapy/*methods
MH  - Adult
MH  - Anesthesia, Obstetrical/methods
MH  - Anesthesia, Spinal/methods
MH  - Antiemetics/*therapeutic use
MH  - Cesarean Section/*adverse effects/methods
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Ondansetron/*therapeutic use
MH  - Patient Satisfaction
MH  - Postoperative Nausea and Vomiting/drug therapy/prevention & control/*therapy
MH  - Pregnancy
MH  - Prospective Studies
EDAT- 2011/07/16 06:00
MHDA- 2012/04/20 06:00
CRDT- 2011/07/16 06:00
PHST- 2010/11/15 00:00 [received]
PHST- 2011/06/22 00:00 [accepted]
PHST- 2011/07/16 06:00 [entrez]
PHST- 2011/07/16 06:00 [pubmed]
PHST- 2012/04/20 06:00 [medline]
AID - 10.1007/s00540-011-1198-0 [doi]
PST - ppublish
SO  - J Anesth. 2011 Oct;25(5):698-703. doi: 10.1007/s00540-011-1198-0. Epub 2011 Jul
      15.


PMID- 21761137
OWN - NLM
STAT- MEDLINE
DCOM- 20110929
LR  - 20211020
IS  - 1432-1203 (Electronic)
IS  - 0340-6717 (Linking)
VI  - 130
IP  - 3
DP  - 2011 Sep
TI  - Biobanking and public health: is a human rights approach the tie that binds?
PG  - 451-63
LID - 10.1007/s00439-011-1061-2 [doi]
AB  - Ethical principles guiding public health and genomic medicine are often at odds: 
      whereas public health practice adopts collectivist principles that emphasize
      population-based benefits, recent advances in genomic and personalized medicine
      are grounded in an individualist ethic that privileges informed consent, and the 
      balancing of individual risk and benefit. Indeed, the attraction of personalized 
      medicine is the promise it holds out to help individuals get the "right medicine 
      for the right problem at the right time." Research biobanks are an effective tool
      in the genomic medicine toolbox. Biobanking in public health presents a unique
      case study to unpack some of these issues in more detail. For example, there is a
      long history of using banked tissue obtained under clinical diagnostic conditions
      for later public health uses. But despite the collectivist approach of public
      health, the principles applied to the ethical challenges of biobanking (e.g.
      informed consent, autonomy, privacy) remain individualist. We demonstrate the
      value of using human rights as a public health ethics framework to address this
      tension in biobanking by applying it to two illustrative cases.
FAU - Meslin, Eric M
AU  - Meslin EM
AD  - Indiana University Center for Bioethics, 410 W 10th Street, Suite 3100,
      Indianapolis, IN 46202, USA. emeslin@iupui.edu
FAU - Garba, Ibrahim
AU  - Garba I
LA  - eng
PT  - Journal Article
DEP - 20110715
PL  - Germany
TA  - Hum Genet
JT  - Human genetics
JID - 7613873
SB  - IM
MH  - Biological Specimen Banks/ethics/legislation & jurisprudence
MH  - Genetics, Medical
MH  - *Human Rights
MH  - Humans
MH  - Precision Medicine
MH  - *Public Health
MH  - Social Justice
PMC - PMC7088251
EDAT- 2011/07/16 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/07/16 06:00
PHST- 2011/04/27 00:00 [received]
PHST- 2011/06/30 00:00 [accepted]
PHST- 2011/07/16 06:00 [entrez]
PHST- 2011/07/16 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - 10.1007/s00439-011-1061-2 [doi]
PST - ppublish
SO  - Hum Genet. 2011 Sep;130(3):451-63. doi: 10.1007/s00439-011-1061-2. Epub 2011 Jul 
      15.


PMID- 21761135
OWN - NLM
STAT- MEDLINE
DCOM- 20110929
LR  - 20211020
IS  - 1432-1203 (Electronic)
IS  - 0340-6717 (Linking)
VI  - 130
IP  - 3
DP  - 2011 Sep
TI  - Biobanking and international interoperability: samples.
PG  - 369-76
LID - 10.1007/s00439-011-1068-8 [doi]
AB  - In terms of sample exchange, international collaborations between biobanks, or
      between biobanks and their research partners, have two important aspects. First, 
      the donors' consent usually implies that the scope and purpose of any sample
      transfer to third parties is subject to major constraints. Since the legal,
      ethical and political framework of biobanking may differ substantially, even
      between countries of comparable jurisdictional systems, general rules for the
      international sharing of biomaterial are difficult, if not impossible, to define.
      Issues of uncertainty include the right to transfer the material, the scope of
      research allowed, and intellectual property rights. Since suitable means of
      international law enforcement may not be available in the context of biobanking, 
      collaborators are advised to clarify any residual uncertainty by means of
      bilateral contracts, for example, in the form of material transfer agreements.
      Second, biobank partners may rightly expect that the biomaterial they receive for
      further analysis attains a certain level of quality. This implies that a biobank 
      has to implement stringent quality control measures covering, in addition to the 
      material transfer itself, the whole process of material acquisition, transport,
      pre-analytical handling and storage. Again, it may be advisable for biobank
      partners to claim contractual warranties for the type and quality of the
      biomaterial they wish to acquire.
FAU - Kiehntopf, Michael
AU  - Kiehntopf M
AD  - Institute of Clinical Chemistry and Laboratory Diagnostics, Jena University
      Hospital, 07740 Jena, Germany. michael.kiehntopf@med.uni-jena.de
FAU - Krawczak, Michael
AU  - Krawczak M
LA  - eng
PT  - Journal Article
DEP - 20110715
PL  - Germany
TA  - Hum Genet
JT  - Human genetics
JID - 7613873
SB  - IM
MH  - *Biological Specimen Banks/ethics/legislation & jurisprudence/statistics &
      numerical data
MH  - Electronic Data Processing
MH  - Informed Consent
MH  - Intellectual Property
MH  - *International Cooperation
MH  - Quality Control
MH  - Specimen Handling
EDAT- 2011/07/16 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/07/16 06:00
PHST- 2011/05/31 00:00 [received]
PHST- 2011/07/01 00:00 [accepted]
PHST- 2011/07/16 06:00 [entrez]
PHST- 2011/07/16 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - 10.1007/s00439-011-1068-8 [doi]
PST - ppublish
SO  - Hum Genet. 2011 Sep;130(3):369-76. doi: 10.1007/s00439-011-1068-8. Epub 2011 Jul 
      15.


PMID- 21757390
OWN - NLM
STAT- MEDLINE
DCOM- 20111223
LR  - 20110729
IS  - 1769-6682 (Electronic)
IS  - 1297-9589 (Linking)
VI  - 39
IP  - 7-8
DP  - 2011 Jul-Aug
TI  - [Embryo donation: why is there a delay in the implementation in France? A
      discussion on the practical, ethical and psychological dilemmas].
PG  - 433-7
LID - 10.1016/j.gyobfe.2011.03.004 [doi]
AB  - Since 1999, French legislation has stipulated that embryo donation is one of the 
      possibilities afforded to couples who have a surplus of cryopreserved embryos.
      Donation of embryos with no foreseeable future use by the genetic couple can
      therefore be given to infertile couples. In practice however, since the
      authorization of this novel Medically Assisted Reproduction technique, embryo
      donation is not widely performed in France even though it is not technically
      difficult. Why then is there reluctance towards the implementation of embryo
      donation in France? The aim of this article is to analyze the grounds for the
      delay in the realization of embryo donation in France. Our findings propose that 
      a myriad of factors including organizational, ethical and psychological
      determinants have deterred the implementation of embryo donation in France.
CI  - Copyright (c) 2011 Elsevier Masson SAS. All rights reserved.
FAU - Temstet, R
AU  - Temstet R
AD  - Service de gynecologie-obstetrique et medecine de la reproduction, centre de
      gynecologie-obstetrique (CGO), CHU d'Amiens, 124 rue Camille-Desmoulins, Amiens
      cedex 01, France. rtemstet@hotmail.com
FAU - Devaux, A
AU  - Devaux A
FAU - Lourdel, E
AU  - Lourdel E
FAU - Cabry, R
AU  - Cabry R
FAU - Brzakowski, M
AU  - Brzakowski M
FAU - Copin, H
AU  - Copin H
FAU - Merviel, P
AU  - Merviel P
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Accueil d'embryon: pourquoi tant de retard a la mise en place en France ?
      Difficultes pratiques, ethiques et psychologiques.
DEP - 20110714
PL  - France
TA  - Gynecol Obstet Fertil
JT  - Gynecologie, obstetrique & fertilite
JID - 100936305
SB  - IM
MH  - Bioethical Issues
MH  - Embryo Disposition/*ethics/psychology
MH  - Embryo Transfer/*ethics/psychology
MH  - Female
MH  - Fertilization in Vitro/*ethics/psychology
MH  - France
MH  - Humans
MH  - Infertility/therapy
MH  - Oocyte Donation/*ethics/psychology
MH  - Pregnancy
MH  - Pregnancy Rate
EDAT- 2011/07/16 06:00
MHDA- 2011/12/24 06:00
CRDT- 2011/07/16 06:00
PHST- 2010/09/05 00:00 [received]
PHST- 2011/07/16 06:00 [entrez]
PHST- 2011/07/16 06:00 [pubmed]
PHST- 2011/12/24 06:00 [medline]
AID - S1297-9589(11)00101-9 [pii]
AID - 10.1016/j.gyobfe.2011.03.004 [doi]
PST - ppublish
SO  - Gynecol Obstet Fertil. 2011 Jul-Aug;39(7-8):433-7. doi:
      10.1016/j.gyobfe.2011.03.004. Epub 2011 Jul 14.


PMID- 21756382
OWN - NLM
STAT- MEDLINE
DCOM- 20111208
LR  - 20190608
IS  - 1677-6119 (Electronic)
IS  - 1677-5538 (Linking)
VI  - 37
IP  - 3
DP  - 2011 May-Jun
TI  - Clamp ablation of the testes compared to bilateral orchiectomy as androgen
      deprivation therapy for advanced prostate cancer.
PG  - 347-54; discussion 354
AB  - PURPOSE: Burdizzo clamp ablation of the testes (CAT) may provide an incisionless,
      cost-effective form of androgen deprivation therapy (ADT) in men with
      adenocarcinoma of the prostate (ACP) who find bilateral orchiectomy (BO)
      unacceptable or can not afford medical ADT. The aim of this study was to compare 
      CAT with BO as primary ADT in men with ACP. MATERIALS AND METHODS: Written,
      informed consent was obtained from men with locally advanced or metastatic ACP.
      Patients were prospectively randomized to BO (n = 9) or CAT (n = 10) under local 
      anaesthesia, and were evaluated 3 and 7 days, 6 weeks and 3 months
      post-procedure. The protocol was approved by the local institutional ethics
      committee. Statistical analysis was performed using Student's, Mann-Whitney's and
      Fisher's tests. RESULTS: Mean duration of the procedure was significantly longer 
      for BO than CAT (16.9 vs. 10.9 minutes). Mean pain scores during and after the
      procedure did not differ significantly. Serum testosterone decreased
      significantly on days 3 and 7 after CAT, but increased at 6 weeks, and was
      significantly higher than after BO. Serum luteinizing hormone increased
      significantly from day 3 after BO and from day 7 after CAT. Serum prostate
      specific antigen decreased significantly after BO, but not after CAT. Minor
      complications were more common after BO (89%) than CAT (40%). In the 9 men who
      did not achieve castrate levels of testosterone after CAT, BO was performed.
      CONCLUSIONS: CAT was quicker to perform and had a lower complication rate, but
      was not as effective as BO in achieving castrate serum testosterone levels.
FAU - Zarrabi, A D
AU  - Zarrabi AD
AD  - Department of Urology, University of Stellenbosch and Tygerberg Hospital, Western
      Cape, South Africa.
FAU - Heyns, C F
AU  - Heyns CF
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - Brazil
TA  - Int Braz J Urol
JT  - International braz j urol : official journal of the Brazilian Society of Urology
JID - 101158091
RN  - 3XMK78S47O (Testosterone)
RN  - 9002-67-9 (Luteinizing Hormone)
RN  - EC 3.4.21.77 (Prostate-Specific Antigen)
SB  - IM
MH  - Adenocarcinoma/blood/pathology/*surgery
MH  - Aged
MH  - Equipment Design
MH  - Feasibility Studies
MH  - Humans
MH  - Luteinizing Hormone/blood
MH  - Male
MH  - Middle Aged
MH  - Orchiectomy/adverse effects/instrumentation/*methods
MH  - Pain Measurement
MH  - Pain, Postoperative/etiology
MH  - Prostate-Specific Antigen/blood
MH  - Prostatic Neoplasms/blood/pathology/*surgery
MH  - Testis
MH  - Testosterone/blood
MH  - Time Factors
EDAT- 2011/07/16 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/16 06:00
PHST- 2010/11/29 00:00 [accepted]
PHST- 2011/07/16 06:00 [entrez]
PHST- 2011/07/16 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - IBJUv37n3a7 [pii]
AID - 10.1590/s1677-55382011000300008 [doi]
PST - ppublish
SO  - Int Braz J Urol. 2011 May-Jun;37(3):347-54; discussion 354. doi:
      10.1590/s1677-55382011000300008.


PMID- 21756069
OWN - NLM
STAT- MEDLINE
DCOM- 20120312
LR  - 20120109
IS  - 1364-6915 (Electronic)
IS  - 1360-7863 (Linking)
VI  - 16
IP  - 2
DP  - 2012
TI  - An exploratory study of inducing positive expectancies for psychotherapy.
PG  - 162-6
LID - 10.1080/13607863.2011.586623 [doi]
AB  - OBJECTIVES: The goal of this study was to determine whether explicit presentation
      of outcome data about the effectiveness of psychotherapy among older adults
      increased positive expectancy for treatment. METHOD: The study included an
      ethically diverse sample of 50 adults over age 60 who screened positive for
      depression and agreed to participate in the BRIGHTEN Program, an
      interdisciplinary geriatric mental health program. Prior to treatment initiation,
      we presented participants with outcome data about psychotherapy, asked
      participants to rate and respond to the data, and asked participants about prior 
      experience with mental health treatment. These data were collected via
      semi-structured interviews. RESULTS: Higher importance ratings for the outcome
      data were significantly associated with starting psychotherapy (r = 0.30, p =
      0.04). Depression severity predicted importance assigned to the outcome data (ss 
      = 0.36, p = 0.03), more severely depressed participants rated the outcome data as
      more important. Qualitative analyses indicated that the presentation of outcome
      data increased hopefulness for successful treatment. In a hierarchical regression
      analysis, hopefulness in the data predicted data importance ratings, above and
      beyond the influence of depression severity (ss = 0.50, p < 0.01). CONCLUSION:
      Our results suggest that information about the effectiveness of psychotherapy was
      important to participants and was associated with starting psychotherapy. High
      importance ratings for the data were primarily driven by the data increasing
      hopefulness for successful treatment outcomes. Although this study was
      exploratory, it suggests that explicit presentation of the effectiveness of
      psychotherapy may create positive expectancies for treatment among older adults.
FAU - Woodhead, Erin L
AU  - Woodhead EL
AD  - Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL,
      USA. adriel@unt.edu
FAU - Ivan, Iulia I
AU  - Ivan II
FAU - Emery, Erin E
AU  - Emery EE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110714
PL  - England
TA  - Aging Ment Health
JT  - Aging & mental health
JID - 9705773
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Attitude to Health
MH  - Decision Making
MH  - Depressive Disorder/*therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Patient Education as Topic/*methods
MH  - *Psychotherapy
MH  - Treatment Outcome
EDAT- 2011/07/16 06:00
MHDA- 2012/03/13 06:00
CRDT- 2011/07/16 06:00
PHST- 2011/07/16 06:00 [entrez]
PHST- 2011/07/16 06:00 [pubmed]
PHST- 2012/03/13 06:00 [medline]
AID - 10.1080/13607863.2011.586623 [doi]
PST - ppublish
SO  - Aging Ment Health. 2012;16(2):162-6. doi: 10.1080/13607863.2011.586623. Epub 2011
      Jul 14.


PMID- 21755841
OWN - NLM
STAT- MEDLINE
DCOM- 20110823
LR  - 20190923
IS  - 1537-0240 (Print)
IS  - 1537-0240 (Linking)
VI  - 11
IP  - 5
DP  - 2011 May-Jun
TI  - Avoid ethical violations and the lawsuits they can cause.
PG  - 25-6
FAU - McQuilkin, Deb
AU  - McQuilkin D
AD  - University of South Carolina, Columbia, SC, USA. deborahm@mailbox.sc.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - MGMA Connex
JT  - MGMA connexion
JID - 101127723
MH  - *Ethics, Institutional
MH  - *Ethics, Professional
MH  - Fraud/economics/*prevention & control
MH  - Health Care Reform/economics/*standards
MH  - Humans
MH  - *Social Justice
MH  - United States
EDAT- 2011/07/16 06:00
MHDA- 2011/08/24 06:00
CRDT- 2011/07/16 06:00
PHST- 2011/07/16 06:00 [entrez]
PHST- 2011/07/16 06:00 [pubmed]
PHST- 2011/08/24 06:00 [medline]
PST - ppublish
SO  - MGMA Connex. 2011 May-Jun;11(5):25-6.


PMID- 21755790
OWN - NLM
STAT- MEDLINE
DCOM- 20110728
LR  - 20190719
IS  - 0029-6570 (Print)
IS  - 0029-6570 (Linking)
VI  - 25
IP  - 40
DP  - 2011 Jun 8-14
TI  - On the right path.
PG  - 24-5
AB  - The RCN has re-formed its ethics committee to help nurses deal with the moral
      dilemmas that they face in their day-to-day practice.
FAU - Wallis, Lynne
AU  - Wallis L
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Stand
JT  - Nursing standard (Royal College of Nursing (Great Britain) : 1987)
JID - 9012906
MH  - Cultural Competency
MH  - Ethics, Nursing
MH  - Humans
MH  - *Morals
MH  - Nurses/*psychology
MH  - Religion
MH  - Societies, Nursing
MH  - United Kingdom
EDAT- 2011/07/16 06:00
MHDA- 2011/07/29 06:00
CRDT- 2011/07/16 06:00
PHST- 2011/07/16 06:00 [entrez]
PHST- 2011/07/16 06:00 [pubmed]
PHST- 2011/07/29 06:00 [medline]
AID - 10.7748/ns.25.40.24.s26 [doi]
PST - ppublish
SO  - Nurs Stand. 2011 Jun 8-14;25(40):24-5. doi: 10.7748/ns.25.40.24.s26.


PMID- 21740661
OWN - NLM
STAT- MEDLINE
DCOM- 20111114
LR  - 20180118
IS  - 1815-7920 (Electronic)
IS  - 1027-3719 (Linking)
VI  - 15 Suppl 2
DP  - 2011 Jun
TI  - Modeling social, environmental and biological determinants of tuberculosis.
PG  - 64-70
LID - 10.5588/ijtld.10.0535 [doi]
AB  - Mathematical models have facilitated our understanding of infectious diseases
      dynamics and proved useful tools to compare control scenarios when interventional
      studies are not feasible or ethical. Here, we summarize evidence linking social, 
      economic and biologic determinants to tuberculosis (TB) and review modeling
      approaches that have been used to understand their contribution to the epidemic
      dynamics of TB. Specifically, we find evidence for associations between smoking, 
      indoor air pollution, diabetes mellitus, alcohol, nutritional status, crowding,
      migration, aging and economic trends, and the occurrence of TB infection and/or
      disease. We outline some methodological problems inherent to the study of these
      associations; these include study design issues, reverse causality and
      misclassification of both exposure and outcomes. We then go on to review two
      existing approaches to modeling the impact of determinants and the effect of
      interventions: the population attributable fraction model, which estimates the
      proportion of the TB burden that would be averted if exposure to a risk factor
      were eliminated from the population, and deterministic epidemic models that
      capture transmission dynamics and the indirect effects of interventions. We
      conclude by defining research priorities in both the study of specific
      determinants and the development of appropriate models to assess the impact of
      addressing these determinants.
FAU - Murray, M
AU  - Murray M
AD  - Department of Epidemiology, Harvard School of Public Health, Boston,
      Massachusetts, USA; Division of Global Health Equity, Brigham and Women's
      Hospital, Boston, Massachusetts, USA; Infectious Disease Unit, Massachusetts
      General Hospital, Boston, Massachusetts, USA.
FAU - Oxlade, O
AU  - Oxlade O
AD  - Respiratory Epidemiology Unit, Department of Epidemiology, Biostatistics and
      Occupational Health, McGill University, Montreal, Quebec, Canada.
FAU - Lin, H-H
AU  - Lin HH
AD  - Department of Community Health, Mennonite Christian Hospital, Hualien, Taiwan;
      Graduate Institute of Epidemiology, National Taiwan University, Taipei, Taiwan;
      International Union Against Tuberculosis and Lung Disease, Paris, France.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - France
TA  - Int J Tuberc Lung Dis
JT  - The international journal of tuberculosis and lung disease : the official journal
      of the International Union against Tuberculosis and Lung Disease
JID - 9706389
SB  - IM
MH  - *Environment
MH  - Epidemiologic Research Design
MH  - Humans
MH  - *Models, Theoretical
MH  - Population Surveillance
MH  - Risk Assessment
MH  - Risk Factors
MH  - *Socioeconomic Factors
MH  - Tuberculosis/*epidemiology/transmission
EDAT- 2011/07/16 06:00
MHDA- 2011/11/15 06:00
CRDT- 2011/07/12 06:00
PHST- 2011/07/12 06:00 [entrez]
PHST- 2011/07/16 06:00 [pubmed]
PHST- 2011/11/15 06:00 [medline]
AID - 10.5588/ijtld.10.0535 [doi]
PST - ppublish
SO  - Int J Tuberc Lung Dis. 2011 Jun;15 Suppl 2:64-70. doi: 10.5588/ijtld.10.0535.


PMID- 21740656
OWN - NLM
STAT- MEDLINE
DCOM- 20111114
LR  - 20180118
IS  - 1815-7920 (Electronic)
IS  - 1027-3719 (Linking)
VI  - 15 Suppl 2
DP  - 2011 Jun
TI  - The ethics of clinical and epidemiological research.
PG  - 25-29
LID - 10.5588/ijtld.10.0618 [doi]
AB  - The global burden of tuberculosis (TB) demands that research be undertaken. The
      vulnerability of the populations most at risk for TB demands that such research
      be subject to ethical review to protect their rights and interests. In this brief
      article we cannot review the vast and important literature bearing on the ethics 
      of clinical and epidemiological research and public health surveillance. Instead,
      we have focused on three questions that have been at the center of discussion and
      debate and which have special relevance for TB. First, we examine a question that
      has special bearing when wealthy nations or international organizations carry out
      research in poor countries: what does justice require in the post trial period?
      Second, we examine the question of how the principles of consent and
      confidentiality may require modification in record-based epidemiological
      research. Third, we look at the challenges posed by public health surveillance,
      which in many cases requires case reporting by clinicians to public health
      agencies. By way of conclusion, we take note of the centrality of enhancing the
      institutional capacities for ethical review of research in poor nations.
FAU - Bayer, R
AU  - Bayer R
AD  - Center for History and Ethics of Public Health, Mailman School of Public Health, 
      Columbia University, New York, New York, USA.
FAU - Greco, D B
AU  - Greco DB
AD  - Department of Clinical Medicine, Faculty of Medicine, Universidade Federal de
      Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
FAU - Ramachandran, R
AU  - Ramachandran R
AD  - Tuberculosis Research Centre, Indian Council of Medical Research, Chennai, Tamil 
      Nadu, India.
LA  - eng
PT  - Journal Article
PL  - France
TA  - Int J Tuberc Lung Dis
JT  - The international journal of tuberculosis and lung disease : the official journal
      of the International Union against Tuberculosis and Lung Disease
JID - 9706389
SB  - IM
MH  - Biomedical Research/economics/*ethics
MH  - Clinical Trials as Topic/ethics
MH  - Confidentiality
MH  - *Developing Countries/economics
MH  - Disease Notification
MH  - Epidemiology/economics/*ethics
MH  - Health Services Accessibility/ethics
MH  - *Human Rights/economics
MH  - Humans
MH  - Informed Consent
MH  - Public Health/economics/*ethics
MH  - Social Justice
MH  - Standard of Care/ethics
MH  - *Tuberculosis/diagnosis/drug therapy/epidemiology/prevention & control
MH  - *Vulnerable Populations
EDAT- 2011/07/16 06:00
MHDA- 2011/11/15 06:00
CRDT- 2011/07/12 06:00
PHST- 2011/07/12 06:00 [entrez]
PHST- 2011/07/16 06:00 [pubmed]
PHST- 2011/11/15 06:00 [medline]
AID - 10.5588/ijtld.10.0618 [doi]
PST - ppublish
SO  - Int J Tuberc Lung Dis. 2011 Jun;15 Suppl 2:25-29. doi: 10.5588/ijtld.10.0618.


PMID- 21740655
OWN - NLM
STAT- MEDLINE
DCOM- 20111114
LR  - 20180118
IS  - 1815-7920 (Electronic)
IS  - 1027-3719 (Linking)
VI  - 15 Suppl 2
DP  - 2011 Jun
TI  - Public health measures to control tuberculosis in low-income countries: ethics
      and human rights considerations.
PG  - 19-24
LID - 10.5588/ijtld.10.0412 [doi]
AB  - In low-income countries, tuberculosis (TB) control measures should be guided by
      ethical concerns and human rights obligations. Control programs should consider
      the principles of necessity, reasonableness and effectiveness of means,
      proportionality, distributive justice, and transparency. Certain
      measures-detention, infection control, and treatment to prevent
      transmission-raise particular concerns. While isolation is appropriate under
      certain circumstances, quarantine is never an acceptable control measure for TB, 
      and any detention must be limited by necessity and conducted humanely. States
      have a duty to implement hospital infection control to the extent of their
      available resources and to provide treatment to health care workers (HCWs)
      infected on the job. HCWs, in turn, have an obligation to provide care unless
      conditions are unreasonably and unforeseeably unsafe. Finally, states have an
      obligation to provide adequate access to treatment, as a means of preventing
      transmission, as broadly as possible and in a non-discriminatory fashion. Along
      with treatment, states should provide support to increase treatment adherence and
      retention with respect for patient privacy and autonomy. Compulsory treatment is 
      almost never acceptable. Governments should take care to respect human rights and
      ethical obligations as they execute TB control programs.
FAU - Kraemer, J D
AU  - Kraemer JD
AD  - O'Neill Institute for National and Global Health Law, Georgetown University,
      Washington, DC, USA; Department of Health Systems Administration, Georgetown
      University School of Nursing and Health Studies, Washington, DC, USA; and
      Tiyatien Health, Cambridge, Massachusetts, USA.
FAU - Cabrera, O A
AU  - Cabrera OA
AD  - O'Neill Institute for National and Global Health Law, Georgetown University,
      Washington, DC, USA.
FAU - Singh, J A
AU  - Singh JA
AD  - Centre for the AIDS Programme of Research in South Africa, Nelson R Mandela
      School of Medicine, Durban, South Africa; Ethical, Social, & Cultural Issues
      Advisory Service, Bill & Melinda Gates Foundation's Grand Challenges in Global
      Health Initiative, McLaughlin-Rotman Centre for Global Health, Toronto, Ontario, 
      Canada; and Dalla Lana School of Public Health, and Joint Centre for Bioethics,
      Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
FAU - Depp, T B
AU  - Depp TB
AD  - O'Neill Institute for National and Global Health Law, Georgetown University,
      Washington, DC, USA; University of Pittsburgh School of Medicine, Pittsburgh,
      Pennsylvania, USA.
FAU - Gostin, L O
AU  - Gostin LO
AD  - O'Neill Institute for National and Global Health Law, Georgetown University,
      Washington, DC, USA; Johns Hopkins Bloomberg School of Public Health, Baltimore, 
      Maryland, USA.
LA  - eng
PT  - Journal Article
PL  - France
TA  - Int J Tuberc Lung Dis
JT  - The international journal of tuberculosis and lung disease : the official journal
      of the International Union against Tuberculosis and Lung Disease
JID - 9706389
SB  - IM
MH  - Communicable Disease Control/*economics
MH  - Confidentiality/ethics
MH  - Developing Countries/*economics
MH  - Health Care Costs/*ethics
MH  - Health Personnel/economics/ethics
MH  - *Health Services Accessibility/economics/ethics
MH  - Human Rights/*economics
MH  - Humans
MH  - Moral Obligations
MH  - *National Health Programs/economics/ethics
MH  - Occupational Health Services/economics/ethics
MH  - Personal Autonomy
MH  - *Public Health/economics/ethics
MH  - Quarantine/economics/ethics
MH  - Tuberculosis/diagnosis/*drug therapy/prevention & control/transmission
EDAT- 2011/07/16 06:00
MHDA- 2011/11/15 06:00
CRDT- 2011/07/12 06:00
PHST- 2011/07/12 06:00 [entrez]
PHST- 2011/07/16 06:00 [pubmed]
PHST- 2011/11/15 06:00 [medline]
AID - 10.5588/ijtld.10.0412 [doi]
PST - ppublish
SO  - Int J Tuberc Lung Dis. 2011 Jun;15 Suppl 2:19-24. doi: 10.5588/ijtld.10.0412.


PMID- 21740654
OWN - NLM
STAT- MEDLINE
DCOM- 20111114
LR  - 20180118
IS  - 1815-7920 (Electronic)
IS  - 1027-3719 (Linking)
VI  - 15 Suppl 2
DP  - 2011 Jun
TI  - Health care provider obligations in caring for patients with tuberculosis.
PG  - 14-18
LID - 10.5588/ijtld.10.0428 [doi]
AB  - It is well acknowledged that physicians and other health care providers have an
      obligation to provide clinical care to their patients even under occasionally
      difficult circumstances. However, the exact degree and extent of that obligation,
      and the various scenarios under which it might be lessened or even cease to
      exist, have recently become the focus of much discussion and debate. The reason
      for this emerging debate is twofold: the recent occurrence of pandemic viruses
      such as severe acute respiratory syndrome and H1N1, and the emergence of highly
      resistant strains of infectious pathogens such as multi and extensively
      drug-resistant tuberculosis (TB). Health care providers have been asked to place 
      themselves at risk to an extent many did not foresee when they chose to enter
      their profession, and many have done so under difficult conditions, often without
      adequate supplies and support. The present article explores the ethical
      obligations as well as the reciprocal rights of health care providers who are
      caring for patients with TB, with a particular focus on drug-resistant strains of
      the bacterium. It is a condensed version of a World Health Organization (WHO)
      Working Paper prepared for the WHO Working Group on Ethics and Tuberculosis.
FAU - Blackmer, J
AU  - Blackmer J
AD  - Office of Ethics, Professionalism and International Affairs, Canadian Medical
      Association, Ottawa, Ontario, Canada; World Health Organization Working Group on 
      Ethics and Tuberculosis, Geneva, Switzerland.
LA  - eng
PT  - Journal Article
PL  - France
TA  - Int J Tuberc Lung Dis
JT  - The international journal of tuberculosis and lung disease : the official journal
      of the International Union against Tuberculosis and Lung Disease
JID - 9706389
RN  - 0 (Antitubercular Agents)
SB  - IM
MH  - Antitubercular Agents/*therapeutic use
MH  - Attitude of Health Personnel
MH  - Choice Behavior
MH  - *Codes of Ethics
MH  - Drug Resistance, Multiple, Bacterial
MH  - Ethics, Clinical
MH  - *Health Knowledge, Attitudes, Practice
MH  - Health Personnel/*ethics
MH  - Humans
MH  - Infectious Disease Transmission, Patient-to-Professional/ethics
MH  - *Moral Obligations
MH  - Occupational Exposure/ethics
MH  - *Patient Rights
MH  - *Professional Role
MH  - Risk Assessment
MH  - Tuberculosis, Multidrug-Resistant/diagnosis/*drug therapy
EDAT- 2011/07/16 06:00
MHDA- 2011/11/15 06:00
CRDT- 2011/07/12 06:00
PHST- 2011/07/12 06:00 [entrez]
PHST- 2011/07/16 06:00 [pubmed]
PHST- 2011/11/15 06:00 [medline]
AID - 10.5588/ijtld.10.0428 [doi]
PST - ppublish
SO  - Int J Tuberc Lung Dis. 2011 Jun;15 Suppl 2:14-18. doi: 10.5588/ijtld.10.0428.


PMID- 21740653
OWN - NLM
STAT- MEDLINE
DCOM- 20111114
LR  - 20180118
IS  - 1815-7920 (Electronic)
IS  - 1027-3719 (Linking)
VI  - 15 Suppl 2
DP  - 2011 Jun
TI  - Ethical issues in tuberculosis diagnosis and treatment.
PG  - 9-13
LID - 10.5588/ijtld.10.0434 [doi]
AB  - Drug-resistant tuberculosis (TB) has highlighted the need for discussion of
      ethical questions about TB diagnosis and treatment. Drug resistance is a
      human-made phenomenon. It is caused by lack of patient adherence in drug taking
      and/or physician failure in prescription making. The global burden of TB is also 
      partly explained by the lack of industry motivation to develop new TB drugs and
      diagnostics. This article explores the primary ethical issues associated with TB 
      diagnosis and treatment: the human rights requirements regarding universal access
      to care and universal standards of care, treatment exclusion and cessation,
      privacy and stigmatisation in the context of directly observed therapy, and
      diagnostic challenges posed by limited laboratory capacity. Inter alia, it argues
      that: 1) the ethical imperative to improve individual patient care is partly
      based on the need to prevent the spread of infection and the exacerbation of the 
      problem of drug resistance; 2) human rights and the imperative to protect the
      greater good of public health may call for increased regulation of the private
      sector; and 3) industry should be given further incentives to develop new tools
      for TB control.
FAU - Selgelid, M J
AU  - Selgelid MJ
AD  - Centre for Human Bioethics, School of Philosophical, Historical and International
      Studies, Monash University, Clayton, Victoria, Australia.
FAU - Reichman, L B
AU  - Reichman LB
AD  - Global Tuberculosis Institute, New Jersey Medical School, Newark, New Jersey,
      USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - Int J Tuberc Lung Dis
JT  - The international journal of tuberculosis and lung disease : the official journal
      of the International Union against Tuberculosis and Lung Disease
JID - 9706389
RN  - 0 (Antitubercular Agents)
SB  - IM
MH  - Antitubercular Agents/*therapeutic use
MH  - *Developing Countries
MH  - Drug Industry/ethics
MH  - Drug Resistance, Multiple, Bacterial
MH  - Global Health
MH  - Health Services Accessibility/*ethics
MH  - *Human Rights
MH  - Humans
MH  - Public Health/ethics
MH  - Socioeconomic Factors
MH  - Standard of Care/*ethics
MH  - Tuberculosis/*diagnosis/*drug therapy
MH  - Tuberculosis, Multidrug-Resistant/diagnosis/drug therapy
EDAT- 2011/07/16 06:00
MHDA- 2011/11/15 06:00
CRDT- 2011/07/12 06:00
PHST- 2011/07/12 06:00 [entrez]
PHST- 2011/07/16 06:00 [pubmed]
PHST- 2011/11/15 06:00 [medline]
AID - 10.5588/ijtld.10.0434 [doi]
PST - ppublish
SO  - Int J Tuberc Lung Dis. 2011 Jun;15 Suppl 2:9-13. doi: 10.5588/ijtld.10.0434.


PMID- 21740651
OWN - NLM
STAT- MEDLINE
DCOM- 20111114
LR  - 20180118
IS  - 1815-7920 (Electronic)
IS  - 1027-3719 (Linking)
VI  - 15 Suppl 2
DP  - 2011 Jun
TI  - Why ethics matters in tuberculosis prevention, care and control.
PG  - 3-5
LID - 10.5588/ijtld.11.0248 [doi]
FAU - Reis, Andreas
AU  - Reis A
AD  - Department of Ethics, Equity, Trade, and Human Rights, World Health Organization,
      Geneva, Switzerland.
FAU - Jaramillo, Ernesto
AU  - Jaramillo E
AD  - Stop TB Department, World Health Organization, Geneva, Switzerland.
LA  - eng
PT  - Editorial
PL  - France
TA  - Int J Tuberc Lung Dis
JT  - The international journal of tuberculosis and lung disease : the official journal
      of the International Union against Tuberculosis and Lung Disease
JID - 9706389
SB  - IM
MH  - *Communicable Disease Control/standards
MH  - *Developing Countries
MH  - Global Health
MH  - Guideline Adherence
MH  - Health Services Accessibility/*ethics
MH  - Humans
MH  - National Health Programs/*ethics
MH  - *Patient Rights
MH  - Practice Guidelines as Topic
MH  - Tuberculosis/diagnosis/epidemiology/prevention & control/*therapy
MH  - *World Health Organization
EDAT- 2011/07/16 06:00
MHDA- 2011/11/15 06:00
CRDT- 2011/07/12 06:00
PHST- 2011/07/12 06:00 [entrez]
PHST- 2011/07/16 06:00 [pubmed]
PHST- 2011/11/15 06:00 [medline]
AID - 10.5588/ijtld.11.0248 [doi]
PST - ppublish
SO  - Int J Tuberc Lung Dis. 2011 Jun;15 Suppl 2:3-5. doi: 10.5588/ijtld.11.0248.


PMID- 21740649
OWN - NLM
STAT- MEDLINE
DCOM- 20111114
LR  - 20180118
IS  - 1815-7920 (Electronic)
IS  - 1027-3719 (Linking)
VI  - 15 Suppl 2
DP  - 2011 Jun
TI  - The Union's Ethics Advisory Group.
PG  - 1-2
LID - 10.5588/ijtld.11.0071 [doi]
FAU - Edginton, Mary
AU  - Edginton M
AD  - Ethics Advisory Group Chairperson, International Union Against Tuberculosis and
      Lung Disease, Paris, France.
LA  - eng
PT  - Editorial
PL  - France
TA  - Int J Tuberc Lung Dis
JT  - The international journal of tuberculosis and lung disease : the official journal
      of the International Union against Tuberculosis and Lung Disease
JID - 9706389
SB  - IM
MH  - *Advisory Committees
MH  - Biomedical Research/*ethics
MH  - *Developing Countries
MH  - *Ethics Committees
MH  - Global Health
MH  - Health Services Accessibility/ethics
MH  - Humans
MH  - Lung Diseases/*prevention & control
MH  - Poverty/ethics
MH  - Social Justice
MH  - Societies, Medical/*ethics
MH  - Tuberculosis/*prevention & control
EDAT- 2011/07/16 06:00
MHDA- 2011/11/15 06:00
CRDT- 2011/07/12 06:00
PHST- 2011/07/12 06:00 [entrez]
PHST- 2011/07/16 06:00 [pubmed]
PHST- 2011/11/15 06:00 [medline]
AID - 10.5588/ijtld.11.0071 [doi]
PST - ppublish
SO  - Int J Tuberc Lung Dis. 2011 Jun;15 Suppl 2:1-2. doi: 10.5588/ijtld.11.0071.


PMID- 21755590
OWN - NLM
STAT- MEDLINE
DCOM- 20120106
LR  - 20110912
IS  - 1545-5017 (Electronic)
IS  - 1545-5009 (Linking)
VI  - 57
IP  - 6
DP  - 2011 Dec 1
TI  - Clinical advances in hemophilia management.
PG  - 910-20
LID - 10.1002/pbc.23193 [doi]
AB  - Hemophilia is an excellent example in medicine where clinical translation of
      basic science discoveries has transformed the gloomy outlook of the disease. This
      review provides an overview of clinical advances in hemophilia management with a 
      specific focus on the molecular heterogeneity of the disease and progress in
      management of patients with inhibitors. Novel therapeutics and the emerging
      ethical issues in the field of hemophilia are also discussed.
CI  - Copyright (c) 2011 Wiley-Liss, Inc.
FAU - Sharathkumar, Anjali A
AU  - Sharathkumar AA
AD  - Division of Hematology/Oncology and Stem Cell Transplantation, Department of
      Pediatrics, Children's Memorial Hospital, Northwestern University Feinberg School
      of Medicine, Chicago, Illinois 60614-3363, USA.
      asharthkumar@childrensmemorial.org
FAU - Carcao, Manuel
AU  - Carcao M
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110713
PL  - United States
TA  - Pediatr Blood Cancer
JT  - Pediatric blood & cancer
JID - 101186624
SB  - IM
MH  - Hemophilia A/diagnosis/genetics/*therapy
MH  - Humans
EDAT- 2011/07/15 06:00
MHDA- 2012/01/10 06:00
CRDT- 2011/07/15 06:00
PHST- 2011/01/11 00:00 [received]
PHST- 2011/04/11 00:00 [accepted]
PHST- 2011/07/15 06:00 [entrez]
PHST- 2011/07/15 06:00 [pubmed]
PHST- 2012/01/10 06:00 [medline]
AID - 10.1002/pbc.23193 [doi]
PST - ppublish
SO  - Pediatr Blood Cancer. 2011 Dec 1;57(6):910-20. doi: 10.1002/pbc.23193. Epub 2011 
      Jul 13.


PMID- 21755342
OWN - NLM
STAT- MEDLINE
DCOM- 20120419
LR  - 20181201
IS  - 1438-8359 (Electronic)
IS  - 0913-8668 (Linking)
VI  - 25
IP  - 5
DP  - 2011 Oct
TI  - Effects of aminophylline on cognitive recovery after sevoflurane anesthesia.
PG  - 648-56
LID - 10.1007/s00540-011-1190-8 [doi]
AB  - PURPOSE: Aminophylline accelerates the recovery from sevoflurane anesthesia. We
      studied the effects of escalating doses of aminophylline on cognitive and
      clinical recovery after sevoflurane anesthesia. METHODS: After ethical approval
      and informed consent, 150 patients scheduled for elective surgery under
      sevoflurane-fentanyl anesthesia were randomly allocated to receive saline or 2,
      3, 4 or 5 mg/kg of aminophylline (n = 30 for each) at the end of anesthesia (T
      (0)). Short Orientation Memory Concentration Test (SOMCT) scores, entropy values,
      end-tidal sevoflurane concentrations (EtSevo), times to eyes opening and
      extubation, respiratory rate (RR) and tidal volume (TV) were recorded. RESULTS:
      Compared to placebo, patients receiving 2, 3, 4 and 5 mg/kg of aminophylline had 
      higher SOMCT scores [median (25th percentile/75th percentile) 20.6 (19/23), 21.5 
      (21/22), 24.5 (24-25), 25.5 (25/26), respectively, vs. 13.5 (13/14) at 30 min
      after extubation, and 24 (22/26), 25 (24/26), 27.5 (27-28), 27.5 (27/28),
      respectively, vs. 18.5 (18/19) at 45 min after extubation], higher entropy values
      for the first 10 min after T (0), lower EtSevo for the first 4 min after T (0),
      shorter times to eyes opening [5 (4.0/6.0), 5 (4.0/6.0), 4 (2.0/5.5), and 4
      (2.0/6.0), respectively, vs. 9.8 (8.0/11.0) min], shorter times to extubation,
      shorter times to home discharge (P < 0.001), and higher RR and larger TV values. 
      Patients who received 4 and 5 mg/kg of aminophylline showed higher SOMCT scores, 
      6 min shorter times to eyes opening and to extubation, and 58 min shorter times
      to home discharge. CONCLUSION: The administration of escalating doses of
      aminophylline accelerates postoperative cognitive recovery from sevoflurane
      anesthesia, as measured by the SOMCT, due to increased ventilatory elimination of
      sevoflurane.
FAU - El Tahan, Mohamed R
AU  - El Tahan MR
AD  - Anesthesiology Department, College of Medicine, University of Dammam, P.O. 40289,
      Dammam, Al Khobar, 31952, Saudi Arabia. mohamedrefaateltahan@yahoo.com
LA  - eng
SI  - ClinicalTrials.gov/NCT01022151
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20110714
PL  - Japan
TA  - J Anesth
JT  - Journal of anesthesia
JID - 8905667
RN  - 0 (Anesthetics, Inhalation)
RN  - 0 (Anesthetics, Intravenous)
RN  - 0 (Methyl Ethers)
RN  - 0 (Placebos)
RN  - 0 (Purinergic P1 Receptor Antagonists)
RN  - 27Y3KJK423 (Aminophylline)
RN  - 38LVP0K73A (Sevoflurane)
RN  - UF599785JZ (Fentanyl)
SB  - IM
MH  - Adult
MH  - Aminophylline/*therapeutic use
MH  - *Anesthesia Recovery Period
MH  - Anesthesia, General/methods
MH  - Anesthetics, Inhalation/*administration & dosage
MH  - Anesthetics, Intravenous/*administration & dosage
MH  - Cognition/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - Double-Blind Method
MH  - Female
MH  - Fentanyl/pharmacology
MH  - Humans
MH  - Male
MH  - Methyl Ethers/*administration & dosage
MH  - Placebos/administration & dosage
MH  - Prospective Studies
MH  - Purinergic P1 Receptor Antagonists/*therapeutic use
MH  - Sevoflurane
EDAT- 2011/07/15 06:00
MHDA- 2012/04/20 06:00
CRDT- 2011/07/15 06:00
PHST- 2011/03/31 00:00 [received]
PHST- 2011/06/06 00:00 [accepted]
PHST- 2011/07/15 06:00 [entrez]
PHST- 2011/07/15 06:00 [pubmed]
PHST- 2012/04/20 06:00 [medline]
AID - 10.1007/s00540-011-1190-8 [doi]
PST - ppublish
SO  - J Anesth. 2011 Oct;25(5):648-56. doi: 10.1007/s00540-011-1190-8. Epub 2011 Jul
      14.


PMID- 21755230
OWN - NLM
STAT- MEDLINE
DCOM- 20111118
LR  - 20190911
IS  - 1984-0446 (Electronic)
IS  - 0034-7167 (Linking)
VI  - 64
IP  - 2
DP  - 2011 Mar-Apr
TI  - [Perspectives for the teaching of bioethics in undergraduate nursing].
PG  - 393-8
LID - S0034-71672011000200029 [pii]
AB  - The education of ethics and bioethics in schools of nursing in Brazil has
      presented strictly conceptual and deontological approaches, which often bear
      little relation to future professional practice. So the goal of this study was to
      present a proposal for teaching of ethics and bioethics in the integrated
      curriculum in undergraduate nursing Federal University of Sao Joao Del Rei, MG,
      Brazil. The results show that the content is provided in all units curriculum of 
      the course covering the classical dilemma in the practice of care in all stages
      of the life cycle. Furthermore, this approach provides students with the
      development of autonomous and reflective attitudes, confronting culture and
      values with the biopsychosocial aspects.
FAU - Pessalacia, Juliana Dias Reis
AU  - Pessalacia JD
AD  - Departamento de Enfermagem, Universidade Federal de Sao Joao Del Rei, Sao Joao
      Del Rei, MG. juliana@pessalaca.com.br
FAU - Oliveira, Valeria Conceicao de
AU  - Oliveira VC
FAU - Renno, Heloiza Maria Siqueira
AU  - Renno HM
FAU - Guimaraes, Eliete Albano de Azevedo
AU  - Guimaraes EA
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Perspectivas do ensino de bioetica na graduacao em enfermagem.
PL  - Brazil
TA  - Rev Bras Enferm
JT  - Revista brasileira de enfermagem
JID - 7910105
MH  - Bioethics/*education
MH  - Curriculum
MH  - *Education, Nursing
MH  - Ethics, Nursing/*education
EDAT- 2011/07/15 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/15 06:00
PHST- 2010/04/07 00:00 [received]
PHST- 2010/07/27 00:00 [accepted]
PHST- 2011/07/15 06:00 [entrez]
PHST- 2011/07/15 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0034-71672011000200029 [pii]
AID - 10.1590/s0034-71672011000200029 [doi]
PST - ppublish
SO  - Rev Bras Enferm. 2011 Mar-Apr;64(2):393-8. doi: 10.1590/s0034-71672011000200029.


PMID- 21755226
OWN - NLM
STAT- MEDLINE
DCOM- 20111118
LR  - 20190911
IS  - 1984-0446 (Electronic)
IS  - 0034-7167 (Linking)
VI  - 64
IP  - 2
DP  - 2011 Mar-Apr
TI  - [Care in Heidegger: an ontological possibility for nursing].
PG  - 376-80
LID - S0034-71672011000200025 [pii]
AB  - Given the dimensions involving human care, this study aimed at providing a
      reflection on nursing care as an ontological possibility. In Heidegger we
      consider the concepts that underlie the foundation of his thought. These
      reflections offer theoretical resource that allows the recognition that live in
      the everyday actions of nursing is a challenge that leads us to a new look at the
      magnitude of care. However, the actions of care should not target only the
      perspective of a philosopher, but live with that thought in search of reflection,
      and find, scrutinizing everything you contribute to a nursing care committed to
      the right, with ethics, and with respect for others.
FAU - de Oliveira, Marilia de Fatima Vieira
AU  - de Oliveira Mde F
AD  - Departamento de Enfermagem, Universidade Federal de Santa Catarina,
      Florianopolis, SC.
FAU - Carraro, Telma Elisa
AU  - Carraro TE
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Cuidado em Heidegger: uma possibilidade ontologica para a enfermagem.
PL  - Brazil
TA  - Rev Bras Enferm
JT  - Revista brasileira de enfermagem
JID - 7910105
MH  - *Philosophy, Nursing
EDAT- 2011/07/15 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/15 06:00
PHST- 2010/02/01 00:00 [received]
PHST- 2010/07/27 00:00 [accepted]
PHST- 2011/07/15 06:00 [entrez]
PHST- 2011/07/15 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0034-71672011000200025 [pii]
AID - 10.1590/s0034-71672011000200025 [doi]
PST - ppublish
SO  - Rev Bras Enferm. 2011 Mar-Apr;64(2):376-80. doi: 10.1590/s0034-71672011000200025.


PMID- 21755217
OWN - NLM
STAT- MEDLINE
DCOM- 20111118
LR  - 20190911
IS  - 1984-0446 (Electronic)
IS  - 0034-7167 (Linking)
VI  - 64
IP  - 2
DP  - 2011 Mar-Apr
TI  - [Educational perspective on nursing care about the maintenance of elimination
      ostomy].
PG  - 322-7
LID - S0034-71672011000200016 [pii]
AB  - This research aimed to describe ostomized users' knowledge and practices with
      regard to the maintenance of an intestinal and urinary elimination ostomy; and to
      analyze the pertinence of sharing this knowledge and practice with fundamental
      nursing care in an outpatient context. The Care-Converging Research method was
      employed. A form was used to identify to ostomized patient and a semistructured
      interview to produce the data. All ethical aspects were complied with. The
      research revealed the need for further dissemination about these users' concrete 
      reality, so that they can feel more welcomed, strengthened to cope with
      difficulties that may arise in their daily reality of living with the surgical
      derivation.
FAU - Martins, Paula Alvarenga de Figueiredo
AU  - Martins PA
AD  - Escola de Enfermagem Anna Nery, Universidade Federal do Rio de Janeiro, Rio de
      Janeiro, RJ. eaepaula@yahoo.com.br
FAU - Alvim, Neide Aparecida Titonelli
AU  - Alvim NA
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Perspectiva educativa do cuidado de enfermagem sobre a manutencao da estomia de
      eliminacao.
PL  - Brazil
TA  - Rev Bras Enferm
JT  - Revista brasileira de enfermagem
JID - 7910105
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Male
MH  - Ostomy/*nursing
MH  - *Patient Education as Topic
EDAT- 2011/07/15 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/15 06:00
PHST- 2010/01/19 00:00 [received]
PHST- 2010/10/17 00:00 [accepted]
PHST- 2011/07/15 06:00 [entrez]
PHST- 2011/07/15 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0034-71672011000200016 [pii]
AID - 10.1590/s0034-71672011000200016 [doi]
PST - ppublish
SO  - Rev Bras Enferm. 2011 Mar-Apr;64(2):322-7. doi: 10.1590/s0034-71672011000200016.


PMID- 21755212
OWN - NLM
STAT- MEDLINE
DCOM- 20111118
LR  - 20190911
IS  - 1984-0446 (Electronic)
IS  - 0034-7167 (Linking)
VI  - 64
IP  - 2
DP  - 2011 Mar-Apr
TI  - [Social representations about humanization of care: ethical and moral
      implications].
PG  - 287-93
LID - S0034-71672011000200011 [pii]
AB  - This research aimed at identifying the ethical aspects in the social
      representations of clients on the humanization and to argue the implications of
      these for the nursing care. A qualitative study was carried out whose data
      collection was by means of semi-structured interview and participant observation 
      with 24 patients hospitalized in a public institution. The social representations
      about humanization of care gain contours of the ethics and the moral, in the
      establishment of gradients of merit of the good treatment, and resolute actions, 
      clinical evaluation and respect to the right of the client. The right to the good
      treatment is not equal for all, what indicates the possible differentiations in
      social representations about citizenship.
FAU - Araujo, Flavia Pacheco
AU  - Araujo FP
AD  - Escola de Enfermagem Anna Nery, Universidade Federal do Rio de Janeiro.
      pacheco.flavia@gmail.com
FAU - de Ferreira, Marcia de Assuncao
AU  - de Ferreira Mde A
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Representacoes sociais sobre humanizacao do cuidado: implicacoes eticas e morais.
PL  - Brazil
TA  - Rev Bras Enferm
JT  - Revista brasileira de enfermagem
JID - 7910105
MH  - *Ethics, Nursing
MH  - *Humanism
MH  - *Morals
MH  - *Sociology
EDAT- 2011/07/15 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/15 06:00
PHST- 2010/01/11 00:00 [received]
PHST- 2010/11/20 00:00 [accepted]
PHST- 2011/07/15 06:00 [entrez]
PHST- 2011/07/15 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0034-71672011000200011 [pii]
AID - 10.1590/s0034-71672011000200011 [doi]
PST - ppublish
SO  - Rev Bras Enferm. 2011 Mar-Apr;64(2):287-93. doi: 10.1590/s0034-71672011000200011.


PMID- 21755204
OWN - NLM
STAT- MEDLINE
DCOM- 20111118
LR  - 20190911
IS  - 1984-0446 (Electronic)
IS  - 0034-7167 (Linking)
VI  - 64
IP  - 2
DP  - 2011 Mar-Apr
TI  - [Nurse's competencies for clinic screening of blood donors].
PG  - 234-40
LID - S0034-71672011000200003 [pii]
AB  - This investigation aimed at identifying nurse's competencies necessary to screen 
      blood donors, from those recommended by the International Council of Nurses. A
      qualitative, descriptive case study was developed at the Hemotherapy Service
      blood bank of a teaching hospital in Porto Alegre, RS, Brazil. Twenty Five
      interviews performed by five nurses hired by the service were observed. For
      observations analysis standard adequacy was used. Six competencies of the
      professional, ethics and legal area and eleven from care provision and management
      were identified. Competencies identified in this study will serve as a basis for 
      practice and to prepare generalist nurses to perform clinic screening of blood
      donors.
FAU - Padilha, Debora Zmuda
AU  - Padilha DZ
AD  - Escola de Enfermagem, Universidade Federal do Rio Grande do Sul, Porto Alegre,
      RS.
FAU - Witt, Regina Rigatto
AU  - Witt RR
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Competencias da enfermeira para a triagem clinica de doadores de sangue.
PL  - Brazil
TA  - Rev Bras Enferm
JT  - Revista brasileira de enfermagem
JID - 7910105
MH  - *Blood Donors
MH  - *Clinical Competence
MH  - *Donor Selection
MH  - Humans
MH  - *Nursing Assessment
EDAT- 2011/07/15 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/15 06:00
PHST- 2009/11/23 00:00 [received]
PHST- 2010/11/20 00:00 [accepted]
PHST- 2011/07/15 06:00 [entrez]
PHST- 2011/07/15 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0034-71672011000200003 [pii]
AID - 10.1590/s0034-71672011000200003 [doi]
PST - ppublish
SO  - Rev Bras Enferm. 2011 Mar-Apr;64(2):234-40. doi: 10.1590/s0034-71672011000200003.


PMID- 21754950
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 1754-9973 (Print)
IS  - 1754-9973 (Linking)
VI  - 4
IP  - 2
DP  - 2011 Jul
TI  - Reasons Why Post-Trial Access to Trial Drugs Should, or Need not be Ensured to
      Research Participants: A Systematic Review.
PG  - 160-184
AB  - Background: researchers and sponsors increasingly confront the issue of whether
      participants in a clinical trial should have post-trial access (PTA) to the trial
      drug. Legislation and guidelines are inconsistent, ambiguous or silent about many
      aspects of PTA. Recent research highlights the potential importance of systematic
      reviews (SRs) of reason-based literatures in informing decision-making in
      medicine, medical research and health policy. PURPOSE: to systematically review
      reasons why drug trial participants should, or need not be ensured PTA to the
      trial drug and the uses of such reasons. DATA SOURCES: databases in
      science/medicine, law and ethics, thesis databases, bibliographies, research
      ethics books and included publications' notes/bibliographies. Publication
      selection: a publication was included if it included a reason as above. See
      article for detailed inclusion conditions. Data extraction and analysis: two
      reviewers extracted and analyzed data on publications and reasons. RESULTS: of
      2060 publications identified, 75 were included. These mentioned reasons based on 
      morality, legality, interests/incentives, or practicality, comprising 36 broad
      (235 narrow) types of reason. None of the included publications, which included
      informal reviews and reports by official bodies, mentioned more than 22 broad (59
      narrow) types. For many reasons, publications differed about the reason's
      interpretation, implications and/or persuasiveness. Publications differed also
      regarding costs, feasibility and legality of PTA. LIMITATIONS: reason types could
      be applied differently. The quality of reasons was not measured. CONCLUSION: this
      review captured a greater variety of reasons and of their uses than any included 
      publication. Decisions based on informal reviews or sub-sets of literature are
      likely to be biased. Research is needed on PTA ethics, costs, feasibility and
      legality and on assessing the quality of reason-based literature.
FAU - Sofaer, Neema
AU  - Sofaer N
AD  - Wellcome Trust Research Fellow, Centre of Medical Law and Ethics, School of Law, 
      King's College London.
FAU - Strech, Daniel
AU  - Strech D
LA  - eng
PT  - Journal Article
DEP - 20110711
PL  - England
TA  - Public Health Ethics
JT  - Public health ethics
JID - 101463048
PMC - PMC3133737
EDAT- 2011/07/15 06:00
MHDA- 2011/07/15 06:01
CRDT- 2011/07/15 06:00
PHST- 2011/07/15 06:00 [entrez]
PHST- 2011/07/15 06:00 [pubmed]
PHST- 2011/07/15 06:01 [medline]
AID - 10.1093/phe/phr013 [doi]
AID - phr013 [pii]
PST - ppublish
SO  - Public Health Ethics. 2011 Jul;4(2):160-184. doi: 10.1093/phe/phr013. Epub 2011
      Jul 11.


PMID- 21754933
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1687-8736 (Electronic)
IS  - 1687-8728 (Linking)
VI  - 2011
DP  - 2011
TI  - Knowledge, Awareness, and Attitudes about Research Ethics among Dental Faculty in
      the Middle East: A Pilot Study.
PG  - 694759
LID - 10.1155/2011/694759 [doi]
AB  - Objective. To assess the knowledge, awareness, and attitudes of dental faculty
      regarding research ethics and research ethics committees (RECs). Design. Through 
      convenience sampling, we distributed a survey to academics at dental faculties at
      two universities in the Middle East. We used descriptive, chi-square, and
      logistic regression statistics to analyze the data. Results. Our response rate
      was 62.5%. A large majority (>90%) held positive attitudes towards RECs; however,
      almost half (44.0%) thought that RECs would delay research. Less than half
      (36.8%) had received prior training in research ethics, and the average score
      they achieved on the questions on research ethics was only 40.2%. Most (>90%),
      however, were favorable towards research ethics education. Finally, some faculty 
      held attitudes regarding certain research ethics practices that were not optimal.
      Conclusions. We conclude that among the dental faculties participating in our
      study, there is broad-based acceptance of RECs and training in research ethics,
      while there are knowledge gaps in research ethics. We recommend further studies
      to determine the generalizability of our findings to other institutions.
FAU - El-Dessouky, Hadir F
AU  - El-Dessouky HF
AD  - Faculty of Dentistry, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
FAU - Abdel-Aziz, Amr M
AU  - Abdel-Aziz AM
FAU - Ibrahim, Chadi
AU  - Ibrahim C
FAU - Moni, Malini
AU  - Moni M
FAU - Abul Fadl, Reham
AU  - Abul Fadl R
FAU - Silverman, Henry
AU  - Silverman H
LA  - eng
GR  - R25 TW007090/TW/FIC NIH HHS/United States
PT  - Journal Article
DEP - 20110703
PL  - Egypt
TA  - Int J Dent
JT  - International journal of dentistry
JID - 101524183
PMC - PMC3132601
EDAT- 2011/07/15 06:00
MHDA- 2011/07/15 06:01
CRDT- 2011/07/15 06:00
PHST- 2011/02/27 00:00 [received]
PHST- 2011/04/29 00:00 [revised]
PHST- 2011/04/30 00:00 [accepted]
PHST- 2011/07/15 06:00 [entrez]
PHST- 2011/07/15 06:00 [pubmed]
PHST- 2011/07/15 06:01 [medline]
AID - 10.1155/2011/694759 [doi]
PST - ppublish
SO  - Int J Dent. 2011;2011:694759. doi: 10.1155/2011/694759. Epub 2011 Jul 3.


PMID- 21752324
OWN - NLM
STAT- MEDLINE
DCOM- 20111006
LR  - 20151119
IS  - 1008-8830 (Print)
IS  - 1008-8830 (Linking)
VI  - 13
IP  - 7
DP  - 2011 Jul
TI  - [Investigation of sleep patterns and sleep disorders in Uigur and Hui children in
      Xinjiang].
PG  - 565-8
AB  - OBJECTIVE: To study the sleep quality and quantity and their influencing factors 
      in Uigur and Hui children in Xinjiang Province. METHODS: From March to December
      of 2007, 912 Uigur and 1019 Hui school children (6 to 14 years) were randomly
      sampled from 6 cities of Xinjing Province. The questionnaire on children's sleep 
      states and sleep environments was filled in by children's parents. RESULTS: The
      mean sleep time of Uigur and Hui children was 10.1+/-1.4 hrs. The sleep time in
      Uigur children was significantly less than that in Hui children (9.7+/-1.2 hrs vs
      10.4+/-1.5 hrs; P<0.05). The mean incidence of sleep disorders was 23.56%. The
      Uigur children had a lower incidence of sleep disorders compared with the Hui
      children (18.42% vs 28.16%; P<0.001). Ethnic group, sleep latency, use of a swing
      bed, family history of snore, watching TV before sleeping, hypertrophy of
      tonsils, eating before sleeping, feeding patterns and recurrent upper respiratory
      tract infection were the factors associated with the sleep quality and quantity. 
      CONCLUSIONS: The influencing factors of sleep quality and quantity are
      multifactorial in Uigur and Hui children in Xinjiang Province. Pediatrician,
      child health care doctors and parents should pay more attention to children's
      sleep. The incidence of sleep disorders is different between Uigur and Hui
      children, suggesting that more research for the prevention and treatment of sleep
      disorders should be performed in different ethic groups.
FAU - Abuzhare, Tajiguli
AU  - Abuzhare T
AD  - Department of Pediatrics, First Affiliated Hospital of Xinjiang Medical
      University, Urumqi 830011, China.
FAU - Xu, Pei-Ru
AU  - Xu PR
FAU - Tiemuer, Amanguli
AU  - Tiemuer A
FAU - Zhang, Ji-Hong
AU  - Zhang JH
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Dang Dai Er Ke Za Zhi
JT  - Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
JID - 100909956
SB  - IM
MH  - Adolescent
MH  - Child
MH  - China/epidemiology/ethnology
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Risk Factors
MH  - Sleep/*physiology
MH  - Sleep Wake Disorders/epidemiology/ethnology/*etiology
MH  - Time Factors
EDAT- 2011/07/15 06:00
MHDA- 2011/10/07 06:00
CRDT- 2011/07/15 06:00
PHST- 2011/07/15 06:00 [entrez]
PHST- 2011/07/15 06:00 [pubmed]
PHST- 2011/10/07 06:00 [medline]
AID - 1008-8830(2011)07-0565-04 [pii]
PST - ppublish
SO  - Zhongguo Dang Dai Er Ke Za Zhi. 2011 Jul;13(7):565-8.


PMID- 21752262
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20211020
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 12
DP  - 2011 Jul 13
TI  - Inhaled nitric oxide for the adjunctive therapy of severe malaria: protocol for a
      randomized controlled trial.
PG  - 176
LID - 10.1186/1745-6215-12-176 [doi]
AB  - BACKGROUND: Severe malaria remains a major cause of global morbidity and
      mortality. Despite the use of potent anti-parasitic agents, the mortality rate in
      severe malaria remains high. Adjunctive therapies that target the underlying
      pathophysiology of severe malaria may further reduce morbidity and mortality.
      Endothelial activation plays a central role in the pathogenesis of severe
      malaria, of which angiopoietin-2 (Ang-2) has recently been shown to function as a
      key regulator. Nitric oxide (NO) is a major inhibitor of Ang-2 release from
      endothelium and has been shown to decrease endothelial inflammation and reduce
      the adhesion of parasitized erythrocytes. Low-flow inhaled nitric oxide (iNO) gas
      is a US FDA-approved treatment for hypoxic respiratory failure in neonates.
      METHODS/DESIGN: This prospective, parallel arm, randomized, placebo-controlled,
      blinded clinical trial compares adjunctive continuous inhaled nitric oxide at 80 
      ppm to placebo (both arms receiving standard anti-malarial therapy), among
      Ugandan children aged 1-10 years of age with severe malaria. The primary endpoint
      is the longitudinal change in Ang-2, an objective and quantitative biomarker of
      malaria severity, which will be analysed using a mixed-effects linear model.
      Secondary endpoints include mortality, recovery time, parasite clearance and
      neurocognitive sequelae. DISCUSSION: Noteworthy aspects of this trial design
      include its efficient sample size supported by a computer simulation study to
      evaluate statistical power, meticulous attention to complex ethical issues in a
      cross-cultural setting, and innovative strategies for safety monitoring and
      blinding to treatment allocation in a resource-constrained setting in sub-Saharan
      Africa. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01255215.
FAU - Hawkes, Michael
AU  - Hawkes M
AD  - Institute of Medical Sciences, University of Toronto, Canada.
FAU - Opoka, Robert O
AU  - Opoka RO
FAU - Namasopo, Sophie
AU  - Namasopo S
FAU - Miller, Christopher
AU  - Miller C
FAU - Thorpe, Kevin E
AU  - Thorpe KE
FAU - Lavery, James V
AU  - Lavery JV
FAU - Conroy, Andrea L
AU  - Conroy AL
FAU - Liles, W Conrad
AU  - Liles WC
FAU - John, Chandy C
AU  - John CC
FAU - Kain, Kevin C
AU  - Kain KC
LA  - eng
SI  - ClinicalTrials.gov/NCT01255215
GR  - MOP-13721/Canadian Institutes of Health Research/Canada
GR  - MOP-244701/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110713
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
RN  - 0 (Angiopoietin-2)
RN  - 0 (Biomarkers)
RN  - 0 (Vasodilator Agents)
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - IM
MH  - Administration, Inhalation
MH  - Angiopoietin-2/blood
MH  - Biomarkers/blood
MH  - Child
MH  - Child, Preschool
MH  - Endothelium, Vascular/*drug effects/metabolism/physiopathology
MH  - Humans
MH  - Infant
MH  - Linear Models
MH  - Malaria/blood/diagnosis/*drug therapy/physiopathology
MH  - Nitric Oxide/*administration & dosage/adverse effects
MH  - Placebo Effect
MH  - Prospective Studies
MH  - *Research Design
MH  - Severity of Illness Index
MH  - Time Factors
MH  - Treatment Outcome
MH  - Uganda
MH  - Vasodilator Agents/*administration & dosage/adverse effects
PMC - PMC3151218
EDAT- 2011/07/15 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/07/15 06:00
PHST- 2011/01/24 00:00 [received]
PHST- 2011/07/13 00:00 [accepted]
PHST- 2011/07/15 06:00 [entrez]
PHST- 2011/07/15 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - 1745-6215-12-176 [pii]
AID - 10.1186/1745-6215-12-176 [doi]
PST - epublish
SO  - Trials. 2011 Jul 13;12:176. doi: 10.1186/1745-6215-12-176.


PMID- 21752247
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20211020
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 12
DP  - 2011 Jul 13
TI  - Mineral trioxyde aggregate versus calcium hydroxide in apexification of non vital
      immature teeth: study protocol for a randomized controlled trial.
PG  - 174
LID - 10.1186/1745-6215-12-174 [doi]
AB  - BACKGROUND: Pulp necrosis is one of the main complications of dental trauma. When
      it happens on an immature tooth, pulp necrosis implies a lack of root maturation 
      and apical closure. A therapy called apexification is required to induce the
      formation of a calcified apical barrier allowing a permanent and hermetic root
      filling. The aim of this prospective randomized clinical trial is to compare
      Mineral Trioxide Aggregate(MTA)with Calcium Hydroxide(CH)as materials used to
      induce root-end closure in necrotic permanent immature incisors. METHODS/DESIGN: 
      This study, promoted by AP-HP, was approved by the ethics committee(CPP Paris Ile
      de France IV). 34 children aged from 6 to 18 years and presenting a non-vital
      permanent incisor are selected. Prior to treatment, an appropriate written
      consent has to be obtained from both parents and from children. Patients are then
      randomly assigned to either the MTA(experimental)or CH(control)groups. Recalls
      are performed after 3, 6 and 12 months to determine the presence or absence of a 
      calcified apical barrier through the use of clinical and radiographic exams.
      Additional criteria such as clinical symptoms, apical radiolucencies, periapical 
      index(PAI)are also noted. TRIAL REGISTRATION: ClinicalTrials.gov no. NCT00472173 
      (First inclusion: May 10, 2007; Last inclusion: April 23, 2009; study completed: 
      April 15, 2010).
CI  - (c) 2011 Beslot-Neveu et al; licensee BioMed Central Ltd.
FAU - Beslot-Neveu, Aurelie
AU  - Beslot-Neveu A
AD  - Service d'Odontologie Hopital Bretonneau, 2 rue Carpeaux 75018 Paris, France.
      aurelie.beslot@yahoo.fr
FAU - Bonte, Eric
AU  - Bonte E
FAU - Baune, Bruno
AU  - Baune B
FAU - Serreau, Raphael
AU  - Serreau R
FAU - Aissat, Fawzia
AU  - Aissat F
FAU - Quinquis, Laurent
AU  - Quinquis L
FAU - Grabar, Sophie
AU  - Grabar S
FAU - Lasfargues, Jean-Jacques
AU  - Lasfargues JJ
LA  - eng
SI  - ClinicalTrials.gov/NCT00472173
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110713
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
RN  - 0 (Aluminum Compounds)
RN  - 0 (Calcium Compounds)
RN  - 0 (Drug Combinations)
RN  - 0 (Oxides)
RN  - 0 (Root Canal Filling Materials)
RN  - 0 (Silicates)
RN  - 0 (mineral trioxide aggregate)
RN  - PF5DZW74VN (Calcium Hydroxide)
SB  - IM
MH  - Adolescent
MH  - Aluminum Compounds/*therapeutic use
MH  - Apexification/*methods
MH  - Calcium Compounds/*therapeutic use
MH  - Calcium Hydroxide/*therapeutic use
MH  - Child
MH  - Dental Pulp Necrosis/diagnostic imaging/*therapy
MH  - Drug Combinations
MH  - Humans
MH  - *Incisor/diagnostic imaging/growth & development
MH  - Oxides/*therapeutic use
MH  - Paris
MH  - Prospective Studies
MH  - Radiography
MH  - *Research Design
MH  - Root Canal Filling Materials/*therapeutic use
MH  - Silicates/*therapeutic use
MH  - Time Factors
MH  - *Tooth Apex/diagnostic imaging/growth & development
MH  - Treatment Outcome
PMC - PMC3144013
EDAT- 2011/07/15 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/07/15 06:00
PHST- 2010/07/15 00:00 [received]
PHST- 2011/07/13 00:00 [accepted]
PHST- 2011/07/15 06:00 [entrez]
PHST- 2011/07/15 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - 1745-6215-12-174 [pii]
AID - 10.1186/1745-6215-12-174 [doi]
PST - epublish
SO  - Trials. 2011 Jul 13;12:174. doi: 10.1186/1745-6215-12-174.


PMID- 21752039
OWN - NLM
STAT- MEDLINE
DCOM- 20140127
LR  - 20130214
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 27
IP  - 3
DP  - 2013 Mar
TI  - The new military medical ethics: legacies of the Gulf Wars and the War on Terror.
PG  - 117-23
LID - 10.1111/j.1467-8519.2011.01920.x [doi]
AB  - United States military medical ethics evolved during its involvement in two
      recent wars, Gulf War I (1990-1991) and the War on Terror (2001-). Norms of
      conduct for military clinicians with regard to the treatment of prisoners of war 
      and the administration of non-therapeutic bioactive agents to soldiers were set
      aside because of the sense of being in a 'new kind of war'. Concurrently, the use
      of radioactive metal in weaponry and the ability to measure the health
      consequences of trade embargos on vulnerable civilians occasioned new concerns
      about the health effects of war on soldiers, their offspring, and civilians
      living on battlefields. Civilian medical societies and medical ethicists fitfully
      engaged the evolving nature of the medical ethics issues and policy changes
      during these wars. Medical codes of professionalism have not been substantively
      updated and procedures for accountability for new kinds of abuses of medical
      ethics are not established. Looking to the future, medicine and medical ethics
      have not articulated a vision for an ongoing military-civilian dialogue to ensure
      that standards of medical ethics do not evolve simply in accord with military
      exigency.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Miles, Steven H
AU  - Miles SH
AD  - University of Minnesota in Minneapolis, MN, USA. Miles001@umn.edu
LA  - eng
PT  - Journal Article
DEP - 20110713
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
RN  - 4OC371KSTK (Uranium)
SB  - IM
MH  - Complicity
MH  - Environmental Exposure/adverse effects
MH  - *Ethics, Medical
MH  - *Gulf War
MH  - Human Experimentation/ethics
MH  - *Human Rights
MH  - Humans
MH  - Military Medicine/*ethics
MH  - *Military Personnel
MH  - *Prisoners of War
MH  - Terrorism/*prevention & control
MH  - United States
MH  - Uranium/adverse effects
EDAT- 2011/07/15 06:00
MHDA- 2014/01/28 06:00
CRDT- 2011/07/15 06:00
PHST- 2011/07/15 06:00 [entrez]
PHST- 2011/07/15 06:00 [pubmed]
PHST- 2014/01/28 06:00 [medline]
AID - 10.1111/j.1467-8519.2011.01920.x [doi]
PST - ppublish
SO  - Bioethics. 2013 Mar;27(3):117-23. doi: 10.1111/j.1467-8519.2011.01920.x. Epub
      2011 Jul 13.


PMID- 21751866
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20181201
IS  - 1557-8577 (Electronic)
IS  - 1549-1684 (Linking)
VI  - 14
IP  - 3
DP  - 2011 Jun
TI  - Personal profile: interview with Alexandra Stolzing, Ph.D. Interview by Vicki
      Glaser.
PG  - 347-8
LID - 10.1089/rej.2011.1219 [doi]
AB  - The interview series in Rejuvenation Research is a unique and, I believe, highly 
      valuable feature of the journal, giving readers insights into the thinking and
      motivation of some of the most influential movers and shakers in the many
      disciplines-not only scientific(1-5) but also political,(6) sociological,(7,8)
      ethical,(9,10) and more-that impinge on the crusade to defeat aging. This issue's
      interview features one of the world's most respected and admired researchers in
      the biology of aging as a result of her incisive evaluations of the work of
      others as well as the quality of her own research. Her clarity of thought and
      expression, to the general public as well as to colleagues, has contributed
      immensely to the process of communication between the field of biomedical
      gerontology and the many constituencies that will be affected by progress against
      aging-a dialogue that, as I(11-19) and others(20-26) have noted recently, is
      essential if we are to develop effective interventions against aging with all
      possible speed.
FAU - Stolzig, Alexandra
AU  - Stolzig A
LA  - eng
PT  - Autobiography
PT  - Biography
PT  - Historical Article
PT  - Interview
PT  - Portrait
PL  - United States
TA  - Rejuvenation Res
JT  - Rejuvenation research
JID - 101213381
SB  - IM
MH  - Germany
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Regenerative Medicine/*history
PS  - Stolzing A
FPS - Stolzing, Alexandra
EDAT- 2011/07/15 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/15 06:00
PHST- 2011/07/15 06:00 [entrez]
PHST- 2011/07/15 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1089/rej.2011.1219 [doi]
PST - ppublish
SO  - Rejuvenation Res. 2011 Jun;14(3):347-8. doi: 10.1089/rej.2011.1219.


PMID- 21751775
OWN - NLM
STAT- MEDLINE
DCOM- 20111212
LR  - 20151119
IS  - 1520-5010 (Electronic)
IS  - 0893-228X (Linking)
VI  - 24
IP  - 8
DP  - 2011 Aug 15
TI  - Structure--activity relationship between the in vivo skin sensitizing potency of 
      analogues of phenyl glycidyl ether and the induction of Nrf2-dependent luciferase
      activity in the KeratinoSens in vitro assay.
PG  - 1312-8
LID - 10.1021/tx200196s [doi]
AB  - Because of regulatory constraints and ethical considerations, research on
      alternatives to animal testing to predict the skin sensitization potential of
      novel chemicals has become a high priority. Ideally, these alternatives should
      not only predict the hazard of novel chemicals but also rate the potency of skin 
      sensitizers. Currently, no alternative method gives reliable potency estimations 
      for a wide range of chemicals in differing structural classes. Performing potency
      estimations within specific structural classes has thus been proposed. Detailed
      structure-activity studies for the in vivo sensitization capacity of a series of 
      analogues of phenyl glycidyl ether (PGE) were recently published. These studies
      are part of an investigation regarding the allergenic activity of epoxy-resin
      monomers. Here we report data on the same chemicals in the KeratinoSens in vitro 
      assay, which is based on a stable transgenic keratinocyte cell line with a
      luciferase gene under the control of an antioxidant response element. A strong
      correlation between the EC3 values in the local lymph node assay (LLNA) and both 
      the luciferase-inducing concentrations and the cytotoxicity in the cell-based
      assay was established for six analogues of PGE. This correlation allowed the
      potency in the LLNA of two novel structurally closely related derivatives to be
      predicted by read-across with errors of 1.4- and 2.6-fold. However, the LLNA EC3 
      values of two structurally different bifunctional monomers were overpredicted on 
      the basis of this data set, indicating that accurate potency estimation by
      read-across based on in vitro data might be restricted to a relatively narrow
      applicability domain.
FAU - Delaine, Tamara
AU  - Delaine T
AD  - Department of Chemistry, Dermatochemistry and Skin Allergy, University of
      Gothenburg , SE-412 96 Gothenburg, Sweden.
FAU - Niklasson, Ida B
AU  - Niklasson IB
FAU - Emter, Roger
AU  - Emter R
FAU - Luthman, Kristina
AU  - Luthman K
FAU - Karlberg, Ann-Therese
AU  - Karlberg AT
FAU - Natsch, Andreas
AU  - Natsch A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110722
PL  - United States
TA  - Chem Res Toxicol
JT  - Chemical research in toxicology
JID - 8807448
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (Phenyl Ethers)
RN  - 44KJQ1655I (phenylglycidyl ether)
RN  - EC 1.13.12.- (Luciferases)
SB  - IM
MH  - Animals
MH  - Cell Line
MH  - Keratinocytes/*drug effects
MH  - Local Lymph Node Assay
MH  - Luciferases/genetics/*metabolism
MH  - Mice
MH  - NF-E2-Related Factor 2/*metabolism
MH  - Phenyl Ethers/*chemistry/toxicity
MH  - Structure-Activity Relationship
EDAT- 2011/07/15 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/07/15 06:00
PHST- 2011/07/15 06:00 [entrez]
PHST- 2011/07/15 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 10.1021/tx200196s [doi]
PST - ppublish
SO  - Chem Res Toxicol. 2011 Aug 15;24(8):1312-8. doi: 10.1021/tx200196s. Epub 2011 Jul
      22.


PMID- 21751729
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20110714
IS  - 1660-9379 (Print)
IS  - 1660-9379 (Linking)
VI  - 7
IP  - 298
DP  - 2011 Jun 8
TI  - [Miscellaneous ethical issues (3)].
PG  - 1284-5
FAU - Nau, Jean-Yves
AU  - Nau JY
AD  - jeanyves.nau@gmail.com
LA  - fre
PT  - Journal Article
TT  - Miscellanees ethiques (3).
PL  - Switzerland
TA  - Rev Med Suisse
JT  - Revue medicale suisse
JID - 101219148
SB  - IM
MH  - Australia
MH  - Down Syndrome/diagnosis
MH  - Europe
MH  - Euthanasia/*ethics/legislation & jurisprudence
MH  - Female
MH  - Humans
MH  - Male
MH  - Persistent Vegetative State
MH  - Posthumous Conception/*ethics/legislation & jurisprudence
MH  - Pregnancy
MH  - Prenatal Diagnosis/*ethics
MH  - Spermatozoa
EDAT- 2011/07/15 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/07/15 06:00
PHST- 2011/07/15 06:00 [entrez]
PHST- 2011/07/15 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
PST - ppublish
SO  - Rev Med Suisse. 2011 Jun 8;7(298):1284-5.


PMID- 21751225
OWN - NLM
STAT- MEDLINE
DCOM- 20120120
LR  - 20220330
IS  - 1097-0258 (Electronic)
IS  - 0277-6715 (Linking)
VI  - 30
IP  - 23
DP  - 2011 Oct 15
TI  - Principles for the ethical analysis of clinical and translational research.
PG  - 2785-92
LID - 10.1002/sim.4282 [doi]
AB  - Statistical analysis is a cornerstone of the scientific method and evidence-based
      medicine, and statisticians serve an increasingly important role in clinical and 
      translational research by providing objective evidence concerning the risks and
      benefits of novel therapeutics. Researchers rely on statistics and informatics as
      never before to generate and test hypotheses and to discover patterns of disease 
      hidden within overwhelming amounts of data. Too often, clinicians and biomedical 
      scientists are not adequately proficient in statistics to analyze data or
      interpret results, and statistical expertise may not be properly incorporated
      within the research process. We argue for the ethical imperative of statistical
      standards, and we present ten nontechnical principles that form a conceptual
      framework for the ethical application of statistics in clinical and translational
      research. These principles are drawn from the literature on the ethics of data
      analysis and the American Statistical Association Ethical Guidelines for
      Statistical Practice.
CI  - Copyright (c) 2011 John Wiley & Sons, Ltd.
FAU - Gelfond, Jonathan A L
AU  - Gelfond JA
AD  - Department of Epidemiology and Biostatistics, UT Health Science Center, San
      Antonio, TX 78229, USA. gelfondjal@uthscsa.edu
FAU - Heitman, Elizabeth
AU  - Heitman E
FAU - Pollock, Brad H
AU  - Pollock BH
FAU - Klugman, Craig M
AU  - Klugman CM
LA  - eng
GR  - KL2 TR001118/TR/NCATS NIH HHS/United States
GR  - R01 GM070335/GM/NIGMS NIH HHS/United States
GR  - UL1 TR000149/TR/NCATS NIH HHS/United States
GR  - KL2 RR025766/RR/NCRR NIH HHS/United States
GR  - KL2 TR000118/TR/NCATS NIH HHS/United States
GR  - UL1 RR025767/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110712
PL  - England
TA  - Stat Med
JT  - Statistics in medicine
JID - 8215016
SB  - IM
CIN - Stat Med. 2012 Dec 20;31(29):4138-9; author reply 4140-1. PMID: 22763861
MH  - Clinical Trials as Topic/*ethics
MH  - Data Interpretation, Statistical
MH  - Evidence-Based Medicine/*ethics
MH  - Humans
MH  - Translational Research, Biomedical/*ethics
PMC - PMC4465206
MID - NIHMS436655
EDAT- 2011/07/14 06:00
MHDA- 2012/01/21 06:00
CRDT- 2011/07/14 06:00
PHST- 2010/10/11 00:00 [received]
PHST- 2011/04/05 00:00 [accepted]
PHST- 2011/07/14 06:00 [entrez]
PHST- 2011/07/14 06:00 [pubmed]
PHST- 2012/01/21 06:00 [medline]
AID - 10.1002/sim.4282 [doi]
PST - ppublish
SO  - Stat Med. 2011 Oct 15;30(23):2785-92. doi: 10.1002/sim.4282. Epub 2011 Jul 12.


PMID- 21750895
OWN - NLM
STAT- MEDLINE
DCOM- 20111202
LR  - 20211020
IS  - 1573-3394 (Electronic)
IS  - 1065-3058 (Linking)
VI  - 19
IP  - 3
DP  - 2011 Sep
TI  - The new Belgian law on biobanks: some comments from an ethical perspective.
PG  - 247-58
LID - 10.1007/s10728-011-0181-0 [doi]
AB  - On 19 December 2008 the Official Journal of Belgium published the 'Law regarding 
      the procurement and use of human body material destined for human medical
      applications or for scientific research purposes'. This paper will comment on
      various aspects of the Law: its scope of application (what is understood by 'body
      material'?); its concept of 'residual human body material' (with far-reaching
      implications for the type of consent required for research); the nature of
      actions with and uses of human body material that are explicitly prohibited; the 
      right of donors to be informed of relevant information revealed by the use of
      their body material; and the special responsibilities placed on hospital ethics
      committees. As will be argued in this paper, several of these provisions are
      highly problematic from an ethical point of view, especially those relating to
      consent. Meanwhile, the Minister of Public Health has asked the Belgian Advisory 
      Committee on Bioethics for advice on the incorporation of the 'presumed consent' 
      model, that applies to post mortem organ donation, into the biobank Law's
      provisions on post mortem removal and use of body material. This aspect of the
      Law effectively extends the 'presumed consent' regime, both from organs to body
      material in general, and from therapeutic uses to research uses.
FAU - Sterckx, Sigrid
AU  - Sterckx S
AD  - Department of Philosophy and Moral Sciences, Bioethics Institute, Ghent
      University, Belgium. Sigrid.Sterckx@UGent.be
FAU - Van Assche, Kristof
AU  - Van Assche K
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Health Care Anal
JT  - Health care analysis : HCA : journal of health philosophy and policy
JID - 9432537
MH  - Autopsy
MH  - Belgium
MH  - Biological Specimen Banks/ethics/*legislation & jurisprudence
MH  - Disclosure/ethics/*legislation & jurisprudence
MH  - Humans
MH  - Informed Consent/ethics/*legislation & jurisprudence
MH  - Presumed Consent/ethics/*legislation & jurisprudence
MH  - Tissue Donors
EDAT- 2011/07/14 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/14 06:00
PHST- 2011/07/14 06:00 [entrez]
PHST- 2011/07/14 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/s10728-011-0181-0 [doi]
PST - ppublish
SO  - Health Care Anal. 2011 Sep;19(3):247-58. doi: 10.1007/s10728-011-0181-0.


PMID- 21749745
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20220330
IS  - 1701-2163 (Print)
IS  - 1701-2163 (Linking)
VI  - 33
IP  - 7
DP  - 2011 Jul
TI  - H1N1 in pregnancy: a tertiary care centre experience.
PG  - 698-704
LID - S1701-2163(16)34954-4 [pii]
LID - 10.1016/S1701-2163(16)34954-4 [doi]
AB  - OBJECTIVE: To elucidate factors pertinent to the course and outcome of H1N1
      infection in pregnancy. METHODS: We conducted a retrospective chart review of
      H1N1-affected pregnant patients at Mount Sinai Hospital in Toronto, Ontario. All 
      women who tested positive for H1N1 from June 1, 2009, to December 5, 2009, were
      identified. Records were reviewed to determine pregnancy status. Information from
      clinic and hospital charts of pregnant patients was gathered using data
      collection forms previously approved by the Mount Sinai Hospital Research Ethics 
      Board. RESULTS: Of 42 patients, 12 were inpatients and 30 were outpatients. Sixty
      percent of patients (25/42) presented in the third trimester, 33% (14/42) had
      comorbidities, and 69% were afebrile and therefore did not have a condition that 
      met the United States Centers for Disease Control and Prevention's definition of 
      influenza-like illness. Antiviral agents were administered promptly in most
      patients, but delays resulted in one third of patients being treated more than 48
      hours from the onset of symptoms. Seventy-one percent (30/42) did not require
      hospitalization, and 58% of hospitalized patients (7/12) were admitted for
      reasons unrelated to H1N1. Although one quarter of hospitalized patients (3/12)
      had delivered at the time of discharge, no deliveries occurred because of H1N1.
      Most patients (91%) delivered at term. One half of the deliveries (51%) were by
      Caesarean section, but none of these were because of H1N1 infection. Most of the 
      infants (88%) were appropriately grown, and none were admitted to the NICU
      because of H1N1. CONCLUSION: Infection with H1N1 in pregnant women has the
      propensity to result in significant maternal and fetal morbidity and mortality,
      and requires vigilance in assessment and prompt treatment. In contrast to reports
      published to date, our cohort experienced a largely uncomplicated course of
      illness, with minimal fetal and maternal impact in most instances.
FAU - Malinowski, Ann Kinga
AU  - Malinowski AK
AD  - Maternal-Fetal Medicine Division, Department of Obstetrics and Gynaecology, Mount
      Sinai Hospital, Toronto ON; University of Toronto, Toronto ON.
FAU - McGeer, Allison
AU  - McGeer A
AD  - Department of Microbiology, Mount Sinai Hospital, Toronto ON; University of
      Toronto, Toronto ON.
FAU - Robertson, Julie
AU  - Robertson J
AD  - Maternal-Fetal Medicine Division, Department of Obstetrics and Gynaecology, Mount
      Sinai Hospital, Toronto ON; University of Toronto, Toronto ON.
FAU - Sermer, Mathew
AU  - Sermer M
AD  - Maternal-Fetal Medicine Division, Department of Obstetrics and Gynaecology, Mount
      Sinai Hospital, Toronto ON; University of Toronto, Toronto ON.
FAU - Farine, Dan
AU  - Farine D
AD  - Maternal-Fetal Medicine Division, Department of Obstetrics and Gynaecology, Mount
      Sinai Hospital, Toronto ON; University of Toronto, Toronto ON.
FAU - Lapinsky, Stephen E
AU  - Lapinsky SE
AD  - Division of Critical Care, Mount Sinai Hospital, Toronto ON; University of
      Toronto, Toronto ON.
FAU - Maxwell, Cynthia
AU  - Maxwell C
AD  - Maternal-Fetal Medicine Division, Department of Obstetrics and Gynaecology, Mount
      Sinai Hospital, Toronto ON; University of Toronto, Toronto ON.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Obstet Gynaecol Can
JT  - Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et
      gynecologie du Canada : JOGC
JID - 101126664
RN  - 0 (Antiviral Agents)
SB  - IM
MH  - Adult
MH  - Antiviral Agents/therapeutic use
MH  - Delivery, Obstetric
MH  - Female
MH  - Fetal Diseases/virology
MH  - Gestational Age
MH  - Hospitalization/statistics & numerical data
MH  - Humans
MH  - *Influenza A Virus, H1N1 Subtype
MH  - Influenza, Human/*complications/epidemiology/therapy
MH  - Ontario/epidemiology
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/epidemiology/therapy/*virology
MH  - Retrospective Studies
EDAT- 2011/07/14 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/07/14 06:00
PHST- 2011/07/14 06:00 [entrez]
PHST- 2011/07/14 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - S1701-2163(16)34954-4 [pii]
AID - 10.1016/S1701-2163(16)34954-4 [doi]
PST - ppublish
SO  - J Obstet Gynaecol Can. 2011 Jul;33(7):698-704. doi:
      10.1016/S1701-2163(16)34954-4.


PMID- 21749559
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20220311
IS  - 1365-2850 (Electronic)
IS  - 1351-0126 (Linking)
VI  - 18
IP  - 6
DP  - 2011 Aug
TI  - Frequency of assault and severity of injury of psychiatric nurses in relation to 
      the nurses' decision to restrain.
PG  - 526-34
LID - 10.1111/j.1365-2850.2011.01699.x [doi]
AB  - Ethical standards and current law demand that acute care psychiatric patients be 
      treated with respect, using the least restrictive interventions. Unfortunately,
      as restraint use has decreased, assault and injury of mental health care workers 
      has increased. Violence against those working in acute care psychiatry is a
      serious global issue that needs further examination. This study provides current,
      in depth information about the nature, frequency and severity of assaults and
      injuries of psychiatric nurses. This study also examined assault and injury in
      relation to the nurse's decision to restrain. The findings of this study were
      compared with findings of an earlier study carried out by one of the authors
      (Moylan) prior to the institution of policies, which are more restrictive in the 
      use of restraint. In a sample of 110 nurses from five institutions, 80% of the
      nurses were assaulted, 65% had been injured and 26% had been seriously injured.
      Injuries included fractures, eye injuries and permanent disability. The number
      and severity of injuries have increased significantly since the 1996 study.
      Nurses who had been injured decided to restrain later in the progression of
      aggression than those who had not been injured.
CI  - (c) 2011 Blackwell Publishing.
FAU - Moylan, L B
AU  - Moylan LB
AD  - Community Research Institute, Molloy College, Rockville Centre, New York, NY
      11570, USA. lmoylan@molloy.edu
FAU - Cullinan, M
AU  - Cullinan M
LA  - eng
PT  - Journal Article
DEP - 20110215
PL  - England
TA  - J Psychiatr Ment Health Nurs
JT  - Journal of psychiatric and mental health nursing
JID - 9439514
MH  - Adult
MH  - Aged
MH  - Aggression/*psychology
MH  - Attitude of Health Personnel
MH  - Decision Making/*physiology
MH  - Female
MH  - Hospitals, Psychiatric
MH  - Humans
MH  - Interview, Psychological
MH  - Male
MH  - Middle Aged
MH  - Nursing Staff, Hospital/*psychology
MH  - Occupational Health
MH  - Psychiatric Nursing/*methods
MH  - Restraint, Physical/*adverse effects/psychology/*statistics & numerical data
MH  - Time Factors
MH  - Trauma Severity Indices
MH  - Violence/prevention & control/psychology
MH  - Wounds and Injuries/psychology
MH  - Young Adult
EDAT- 2011/07/14 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/07/14 06:00
PHST- 2011/07/14 06:00 [entrez]
PHST- 2011/07/14 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - 10.1111/j.1365-2850.2011.01699.x [doi]
PST - ppublish
SO  - J Psychiatr Ment Health Nurs. 2011 Aug;18(6):526-34. doi:
      10.1111/j.1365-2850.2011.01699.x. Epub 2011 Feb 15.


PMID- 21749539
OWN - NLM
STAT- MEDLINE
DCOM- 20111102
LR  - 20110713
IS  - 1365-2834 (Electronic)
IS  - 0966-0429 (Linking)
VI  - 19
IP  - 5
DP  - 2011 Jul
TI  - Exploring confidentiality in the context of nurse whistle blowing: issues for
      nurse managers.
PG  - 655-63
LID - 10.1111/j.1365-2834.2010.01169.x [doi]
AB  - AIM: The aim of this paper is to reveal the experiences and meaning of
      confidentiality for Australian nurses in the context of whistle blowing.
      BACKGROUND: Despite the ethical, legal and moral importance of confidentiality
      within the health-care context, little work has addressed the implications of
      confidentially related to whistle-blowing events. METHODS: The study used
      qualitative narrative inquiry. Eighteen Australian nurses, with first-hand
      experience of whistle blowing, consented to face-to-face semi-structured
      interviews. RESULTS: Four emergent themes relating to confidentiality were
      identified: (1) confidentiality as enforced silence; (2) confidentiality as
      isolating and marginalizing; (3) confidentiality as creating a rumour mill; and
      (4) confidentiality in the context of the public's 'right to know'. CONCLUSIONS: 
      The interpretation and application of confidentiality influences the outcomes of 
      whistle blowing within the context of health-care services. Conversely,
      confidentially can be a protective mechanism for health-care institutions.
      IMPLICATIONS FOR NURSING MANAGEMENT: It is beholden upon nurse manager to
      carefully risk manage whistle-blowing events. It is important that nurse managers
      are aware of the consequences of their interpretation and application of
      confidentiality to whistle-blowing events, and the potentially competing outcomes
      for individuals and the institution.
CI  - (c) 2011 The Authors. Journal compilation (c) 2011 Blackwell Publishing Ltd.
FAU - Jackson, Debra
AU  - Jackson D
AD  - Family and Community Health Research Group, School of Nursing and Midwifery,
      University of Western Sydney, Penrith South, New South Wales, Australia.
      debra.jackson@uws.edu.au
FAU - Peters, Kath
AU  - Peters K
FAU - Hutchinson, Marie
AU  - Hutchinson M
FAU - Edenborough, Michel
AU  - Edenborough M
FAU - Luck, Lauretta
AU  - Luck L
FAU - Wilkes, Lesley
AU  - Wilkes L
LA  - eng
PT  - Journal Article
DEP - 20110526
PL  - England
TA  - J Nurs Manag
JT  - Journal of nursing management
JID - 9306050
MH  - *Attitude of Health Personnel
MH  - Australia
MH  - Confidentiality/*psychology
MH  - Female
MH  - Humans
MH  - Male
MH  - *Nurse Administrators
MH  - Nursing Staff, Hospital/organization & administration/*psychology
MH  - Qualitative Research
MH  - Stress, Psychological
MH  - *Whistleblowing
EDAT- 2011/07/14 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/07/14 06:00
PHST- 2011/07/14 06:00 [entrez]
PHST- 2011/07/14 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
AID - 10.1111/j.1365-2834.2010.01169.x [doi]
PST - ppublish
SO  - J Nurs Manag. 2011 Jul;19(5):655-63. doi: 10.1111/j.1365-2834.2010.01169.x. Epub 
      2011 May 26.


PMID- 21749259
OWN - NLM
STAT- MEDLINE
DCOM- 20120105
LR  - 20211020
IS  - 1556-3669 (Electronic)
IS  - 1530-5627 (Linking)
VI  - 17
IP  - 7
DP  - 2011 Sep
TI  - Data safety and monitoring for research involving remote health monitoring.
PG  - 574-9
LID - 10.1089/tmj.2010.0219 [doi]
AB  - Investigators conducting research involving human subjects are obligated to
      safeguard the wellbeing of the study participants. Other than requiring
      investigators to establish procedures for ongoing monitoring and reporting of
      adverse events, federal regulations do not dictate how human subject safety
      should be ensured. A variety of data safety monitoring (DSM) procedures may be
      acceptable depending on the nature, size, and complexity of the study. However,
      practical guidance for establishing and implementing appropriate DSM plans for
      such studies are lacking. In this article, we provide a review of the DSM
      considerations associated with monitoring health remotely and describe the Pocket
      Personal Assistant for Tracking Health project as an exemplar for how to develop 
      effective DSM plans for research that captures clinical data using remote
      health-monitoring devices. Protecting the safety and welfare of participants is
      one of the most important mandates for research involving human subjects.
      Investigators have an ethical and scientific responsibility to monitor the safety
      of research participants. Investigators typically fulfill this responsibility by 
      monitoring and reporting adverse events.
FAU - Kovach, Karen A
AU  - Kovach KA
AD  - School of Nursing, University of Pittsburgh, Pittsburgh, Pennsylvania 16105, USA.
      kak114@pitt.edu
FAU - Aubrecht, Jill Ann
AU  - Aubrecht JA
FAU - Dew, Mary Amanda
AU  - Dew MA
FAU - Myers, Brad
AU  - Myers B
FAU - Dabbs, Annette Devito
AU  - Dabbs AD
LA  - eng
GR  - R01 NR010711/NR/NINR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110712
PL  - United States
TA  - Telemed J E Health
JT  - Telemedicine journal and e-health : the official journal of the American
      Telemedicine Association
JID - 100959949
SB  - IM
MH  - *Computer Security
MH  - Confidentiality/*standards
MH  - Electronic Health Records/*standards
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Medical Informatics/ethics/standards
MH  - Remote Consultation/*standards
PMC - PMC3158661
EDAT- 2011/07/14 06:00
MHDA- 2012/01/06 06:00
CRDT- 2011/07/14 06:00
PHST- 2011/07/14 06:00 [entrez]
PHST- 2011/07/14 06:00 [pubmed]
PHST- 2012/01/06 06:00 [medline]
AID - 10.1089/tmj.2010.0219 [doi]
PST - ppublish
SO  - Telemed J E Health. 2011 Sep;17(7):574-9. doi: 10.1089/tmj.2010.0219. Epub 2011
      Jul 12.


PMID- 21749239
OWN - NLM
STAT- MEDLINE
DCOM- 20111212
LR  - 20151119
IS  - 1465-3966 (Electronic)
IS  - 1354-8506 (Linking)
VI  - 16
IP  - 4
DP  - 2011 Aug
TI  - Donating organs: a theory-driven inventory of motives.
PG  - 418-29
LID - 10.1080/13548506.2011.555770 [doi]
AB  - Two studies examined the motives that lay behind patients' acceptance or
      reluctance at donating organs after death. They also examined the way these
      motives were related to demographic characteristics, personality, and signing a
      donor card. Six separable motives for donation were found: Financial Incentive,
      Humanistic or Religious Duty, Positive Consideration from Others, Living on
      Through a Receiver, Gift of Life, and Close Others. Five motives for not donating
      were found: Preserving the Absolute Integrity of the Corpus, Strict
      Individualism, Lack of Control over the Use of the Organs, Anonymity of the
      Procedure, and Respecting Family Wishes. These motives were linked to personality
      factors in a meaningful way. Willingness to sign was higher among female
      participants and among participants with lower scores on Integrity of the Corpus 
      and higher scores on Duty and Gift of Life. When Integrity of the Corpus scored
      highly, however, the effect of the other factors was practically eliminated. In
      other words, Integrity of the Corpus acted as a protected value: Trying to change
      people's belief that the integrity of the corpus at death is a sacrosanct issue
      would come with its own ethical issues.
FAU - Guedj, Myriam
AU  - Guedj M
AD  - Department of Psychology, Mirail University, Toulouse, France.
FAU - Sastre, Maria T M
AU  - Sastre MT
FAU - Mullet, Etienne
AU  - Mullet E
LA  - eng
PT  - Journal Article
PL  - England
TA  - Psychol Health Med
JT  - Psychology, health & medicine
JID - 9604099
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Female
MH  - France
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Models, Psychological
MH  - *Motivation
MH  - Personality
MH  - Surveys and Questionnaires
MH  - *Tissue Donors
MH  - Tissue and Organ Procurement
MH  - Young Adult
EDAT- 2011/07/14 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/07/14 06:00
PHST- 2011/07/14 06:00 [entrez]
PHST- 2011/07/14 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 10.1080/13548506.2011.555770 [doi]
PST - ppublish
SO  - Psychol Health Med. 2011 Aug;16(4):418-29. doi: 10.1080/13548506.2011.555770.


PMID- 21749218
OWN - NLM
STAT- MEDLINE
DCOM- 20111220
LR  - 20110715
IS  - 1757-6199 (Electronic)
IS  - 1757-6180 (Linking)
VI  - 3
IP  - 14
DP  - 2011 Jul
TI  - EBF recommendation on the validation of bioanalytical methods for dried blood
      spots.
PG  - 1567-75
LID - 10.4155/bio.11.132 [doi]
AB  - Over the last few years bioanalysts, pharmacokineticists and clinical
      investigators have rediscovered the technique of dried blood spots. The revival
      has provided pharmaceutical R&D a wealth of opportunities to optimize the
      drug-discovery and development process with respect to animal and patient ethics,
      new scientific insights and costs savings. On the bioanalytical front, multiple
      experiments have been performed and a lot of experience has been gained.
      Nevertheless, the technique still has a number of bioanalytical challenges. The
      European Bioanalysis Forum discussed the advantages and hurdles of the technique 
      and summarized their current thinking in a recommendation on the validation of
      bioanalytical methods for dried blood spots, which can be used as a cornerstone
      for further discussions and experiments.
FAU - Timmerman, Philip
AU  - Timmerman P
AD  - Janssen Research & Development, Bioanalysis Department, A Division of Janssen
      Pharmaceutica NV, Beerse, Belgium. ptimmerm@its.jnj.com
FAU - White, Steve
AU  - White S
FAU - Globig, Susanne
AU  - Globig S
FAU - Ludtke, Silke
AU  - Ludtke S
FAU - Brunet, Leonarda
AU  - Brunet L
FAU - Smeraglia, John
AU  - Smeraglia J
LA  - eng
PT  - Journal Article
DEP - 20110712
PL  - England
TA  - Bioanalysis
JT  - Bioanalysis
JID - 101512484
RN  - 0 (Anticoagulants)
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Anticoagulants/chemistry
MH  - Chemistry Techniques, Analytical/*methods/*standards
MH  - Dried Blood Spot Testing/*methods/*standards
MH  - Europe
MH  - Hematocrit
MH  - Humans
MH  - Pharmaceutical Preparations/*blood
MH  - Reproducibility of Results
EDAT- 2011/07/14 06:00
MHDA- 2011/12/21 06:00
CRDT- 2011/07/14 06:00
PHST- 2011/07/14 06:00 [entrez]
PHST- 2011/07/14 06:00 [pubmed]
PHST- 2011/12/21 06:00 [medline]
AID - 10.4155/bio.11.132 [doi]
PST - ppublish
SO  - Bioanalysis. 2011 Jul;3(14):1567-75. doi: 10.4155/bio.11.132. Epub 2011 Jul 12.


PMID- 21748662
OWN - NLM
STAT- MEDLINE
DCOM- 20120111
LR  - 20151119
IS  - 1496-8975 (Electronic)
IS  - 0832-610X (Linking)
VI  - 58
IP  - 10
DP  - 2011 Oct
TI  - A survey of ultrasound use by academic and community anesthesiologists in
      Ontario.
PG  - 929-35
LID - 10.1007/s12630-011-9555-x [doi]
AB  - PURPOSE: The use of ultrasound for central venous catheter (CVC) insertion and
      regional anesthesia (RA) has been recommended to improve efficacy and patient
      safety. We conducted a survey to evaluate the degree to which ultrasound use has 
      been adopted into routine practice by anesthesiologists in the province of
      Ontario, Canada. METHODS: Following approval by the Research Ethics Board at The 
      Hospital for Sick Children, we conducted a web-based survey of anesthesiologists 
      registered with the College of Physicians and Surgeons of Ontario. The
      anesthesiologists surveyed were working in academic or community hospitals. The
      survey elicited information on the degree of routine use of ultrasound for CVC or
      RA blocks, reasons for non-use of ultrasound, and methods of ultrasound training.
      RESULTS: A questionnaire was sent to 450 anesthesiologists via e-mail. There were
      209 (46%) respondents, six of whom were excluded as the anesthesiologists were no
      longer in practice, resulting in 203 responses for analysis. Of these, 163
      anesthesiologists practiced in academic hospitals, and 40 practiced in community 
      hospitals. A larger proportion of academic (60%) vs community (33%)
      anesthesiologists use ultrasound routinely for CVC insertion (P = 0.004). Routine
      use for RA blocks was comparable in both groups. The most common reason given for
      non-use of ultrasound for CVC insertion was "ultrasound is unnecessary for
      safe/effective insertion of CVCs". Peer-to-peer training was the most preferred
      method for improving ultrasound skills. CONCLUSIONS: The use of ultrasound is
      better established in academic than in community anesthesia practice.
      Anesthesiologists in community practice appear to be adopting ultrasound at a
      slower pace, which may be explained by lack of equipment and lack of training.
FAU - Matava, Clyde
AU  - Matava C
AD  - Department of Anesthesia and Pain Medicine, The Hospital for Sick Children, 555
      University Avenue, Toronto, ON M5G 1X8, Canada. clyde.matava@sickkids.ca
FAU - Hayes, Jason
AU  - Hayes J
LA  - eng
PT  - Journal Article
DEP - 20110712
PL  - United States
TA  - Can J Anaesth
JT  - Canadian journal of anaesthesia = Journal canadien d'anesthesie
JID - 8701709
SB  - IM
MH  - Anesthesia, Conduction/*methods
MH  - Anesthesiology/education/methods
MH  - Catheterization, Central Venous/*methods
MH  - Clinical Competence
MH  - Health Care Surveys
MH  - Humans
MH  - Internet
MH  - Ontario
MH  - Peer Group
MH  - Pilot Projects
MH  - Practice Patterns, Physicians'/*statistics & numerical data
MH  - Surveys and Questionnaires
MH  - Ultrasonography, Interventional/*methods
EDAT- 2011/07/13 06:00
MHDA- 2012/01/12 06:00
CRDT- 2011/07/13 06:00
PHST- 2010/11/29 00:00 [received]
PHST- 2011/06/28 00:00 [accepted]
PHST- 2011/07/13 06:00 [entrez]
PHST- 2011/07/13 06:00 [pubmed]
PHST- 2012/01/12 06:00 [medline]
AID - 10.1007/s12630-011-9555-x [doi]
PST - ppublish
SO  - Can J Anaesth. 2011 Oct;58(10):929-35. doi: 10.1007/s12630-011-9555-x. Epub 2011 
      Jul 12.


PMID- 21748341
OWN - NLM
STAT- MEDLINE
DCOM- 20120312
LR  - 20211020
IS  - 1432-1203 (Electronic)
IS  - 0340-6717 (Linking)
VI  - 131
IP  - 2
DP  - 2012 Feb
TI  - Preimplantation genetic diagnosis: state of the art 2011.
PG  - 175-86
LID - 10.1007/s00439-011-1056-z [doi]
AB  - For the last 20 years, preimplantation genetic diagnosis (PGD) has been mostly
      performed on cleavage stage embryos after the biopsy of 1-2 cells and PCR and
      FISH have been used for the diagnosis. The main indications have been single gene
      disorders and inherited chromosome abnormalities. Preimplantation genetic
      screening (PGS) for aneuploidy is a technique that has used PGD technology to
      examine chromosomes in embryos from couples undergoing IVF with the aim of
      helping select the chromosomally 'best' embryo for transfer. It has been applied 
      to patients of advanced maternal age, repeated implantation failure, repeated
      miscarriages and severe male factor infertility. Recent randomised controlled
      trials (RCTs) have shown that PGS performed on cleavage stage embryos for a
      variety of indications does not improve delivery rates. At the cleavage stage,
      the cells biopsied from the embryo are often not representative of the rest of
      the embryo due to chromosomal mosaicism. There has therefore been a move towards 
      blastocyst and polar body biopsy, depending on the indication and regulations in 
      specific countries (in some countries, biopsy of embryos is not allowed).
      Blastocyst biopsy has an added advantage as vitrification of blastocysts, even
      post biopsy, has been shown to be a very successful method of cryopreserving
      embryos. However, mosaicism is also observed in blastocysts. There have been
      dramatic changes in the method of diagnosing small numbers of cells for PGD. Both
      array-comparative genomic hybridisation and single nucleotide polymorphism arrays
      have been introduced clinically for PGD and PGS. For PGD, the use of SNP arrays
      brings with it ethical concerns as a large amount of genetic information will be 
      available from each embryo. For PGS, RCTs need to be conducted using both
      array-CGH and SNP arrays to determine if either will result in an increase in
      delivery rates.
FAU - Harper, Joyce C
AU  - Harper JC
AD  - UCL Centre for PG&D, Institute for Womens Health, University College London,
      London, UK. joyce.harper@ucl.ac.uk
FAU - Sengupta, Sioban B
AU  - Sengupta SB
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110712
PL  - Germany
TA  - Hum Genet
JT  - Human genetics
JID - 7613873
SB  - IM
MH  - Biopsy
MH  - *Blastocyst
MH  - Chromosomes/chemistry
MH  - Comparative Genomic Hybridization
MH  - Embryo, Mammalian/pathology
MH  - Female
MH  - Genetic Testing
MH  - Humans
MH  - Molecular Diagnostic Techniques
MH  - Nucleic Acid Amplification Techniques
MH  - *Polar Bodies
MH  - Polymorphism, Single Nucleotide
MH  - Pregnancy
MH  - Preimplantation Diagnosis/*methods
EDAT- 2011/07/13 06:00
MHDA- 2012/03/13 06:00
CRDT- 2011/07/13 06:00
PHST- 2011/05/21 00:00 [received]
PHST- 2011/06/23 00:00 [accepted]
PHST- 2011/07/13 06:00 [entrez]
PHST- 2011/07/13 06:00 [pubmed]
PHST- 2012/03/13 06:00 [medline]
AID - 10.1007/s00439-011-1056-z [doi]
PST - ppublish
SO  - Hum Genet. 2012 Feb;131(2):175-86. doi: 10.1007/s00439-011-1056-z. Epub 2011 Jul 
      12.


PMID- 21747596
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 0974-7834 (Electronic)
IS  - 0974-7796 (Linking)
VI  - 3
IP  - 2
DP  - 2011 May
TI  - Prospective randomized clinical trial comparing phytotherapy with potassium
      citrate in management of minimal burden (</=8 mm) nephrolithiasis.
PG  - 75-81
LID - 10.4103/0974-7796.82172 [doi]
AB  - AIM: To compare efficacy and tolerability of phytotherapy (PT) vs. potassium
      citrate (KC) in patients with minimal nephrolithiasis. To compare and assess
      changes in value of certain serum (Ca(2)+, PO(4) (3-), uric acid [UA]) and
      urinary (24-hr Ca(2+), PO(4) (3-), UA, citrate, oxalate, and urine pH) parameters
      in patients being treated with PT or KC. MATERIALS AND METHODS: After clearance
      by the local institutional ethics committee, 60 patients of nephrolithiasis who
      had consented for the study, were enrolled (as per entry criteria) and randomized
      into citrate therapy (group-I) or PT (group-II). PT was administered as a
      nutritional supplement, using a lupeol-based extract (Tablet Calcury, two tablets
      twice a day). They were monitored for the changes in the serum and urinary
      biochemical, radiological, and clinical parameters (efficacy and tolerability) as
      per protocol. RESULTS: Group-I patients demonstrated favorable changes in certain
      biochemical parameters (decreased serum calcium, urinary UA/oxalate, increased
      urinary citrate and pH) along with significant symptomatic improvement (decrease 
      in visual analogue pain score with increased stone clearance/reduction in stone
      size). Four (13.3%) patients of group-I had mild upper gastrointestinal
      discomfort which was controlled with antacids. Group-II patients had favorable
      changes in biochemical parameters (decreased serum UA and increased urinary
      citrate) along with significant symptomatic improvement (reduction/clearance in
      the stone size), but without any noticeable side effects. CONCLUSIONS: Medical
      therapies with both KC and PT (with lupeol extract using Calcury) were effective 
      in reducing the stone size and symptoms of nephrolithiasis. It appeared that KC
      was biochemically efficacious in producing some favorable biochemical changes
      with some side effects, whereas PT was probably clinically efficacious in
      hastening stone expulsion (<8 mm) without any observed adverse events. Although
      both the medical therapies were not effective in all aspects, we believe that PT 
      using lupeol-based extract (Calcury) may be used as an alternative form of
      medical therapy in select patients with minimal nephrolithiasis. Long-term
      randomized placebo-controlled trials are needed to better define the precise role
      of lupeol-based PT vs. citrate therapy in minimal nephrolithiasis.
FAU - Singh, Iqbal
AU  - Singh I
AD  - Department of Urology, University College of Medical Sciences (University of
      Delhi) and GTB Hospital, Delhi, India.
FAU - Bishnoi, Ishu
AU  - Bishnoi I
FAU - Agarwal, Vivek
AU  - Agarwal V
FAU - Bhatt, Shuchi
AU  - Bhatt S
LA  - eng
PT  - Journal Article
PL  - India
TA  - Urol Ann
JT  - Urology annals
JID - 101510823
PMC - PMC3130482
OTO - NOTNLM
OT  - Medical therapy
OT  - nephrolithiasis
OT  - phytotherapy
OT  - potassium citrate
EDAT- 2011/07/13 06:00
MHDA- 2011/07/13 06:01
CRDT- 2011/07/13 06:00
PHST- 2010/09/18 00:00 [received]
PHST- 2010/11/14 00:00 [accepted]
PHST- 2011/07/13 06:00 [entrez]
PHST- 2011/07/13 06:00 [pubmed]
PHST- 2011/07/13 06:01 [medline]
AID - 10.4103/0974-7796.82172 [doi]
AID - UA-3-75 [pii]
PST - ppublish
SO  - Urol Ann. 2011 May;3(2):75-81. doi: 10.4103/0974-7796.82172.


PMID- 21746819
OWN - NLM
STAT- MEDLINE
DCOM- 20111109
LR  - 20211020
IS  - 1488-2329 (Electronic)
IS  - 0820-3946 (Linking)
VI  - 183
IP  - 11
DP  - 2011 Aug 9
TI  - The ethics of reusing single-use devices.
PG  - 1245
LID - 10.1503/cmaj.109-3907 [doi]
FAU - Collier, Roger
AU  - Collier R
LA  - eng
PT  - News
DEP - 20110711
PL  - Canada
TA  - CMAJ
JT  - CMAJ : Canadian Medical Association journal = journal de l'Association medicale
      canadienne
JID - 9711805
RN  - 0 (Medical Waste)
SB  - IM
MH  - Canada
MH  - *Disposable Equipment/economics
MH  - *Equipment Reuse/economics/legislation & jurisprudence
MH  - Equipment Safety
MH  - *Ethics, Medical
MH  - Hospitals
MH  - Humans
MH  - Informed Consent
MH  - Medical Waste
MH  - Organizational Policy
MH  - United States
PMC - PMC3153512
EDAT- 2011/07/13 06:00
MHDA- 2011/11/10 06:00
CRDT- 2011/07/13 06:00
PHST- 2011/07/13 06:00 [entrez]
PHST- 2011/07/13 06:00 [pubmed]
PHST- 2011/11/10 06:00 [medline]
AID - cmaj.109-3907 [pii]
AID - 10.1503/cmaj.109-3907 [doi]
PST - ppublish
SO  - CMAJ. 2011 Aug 9;183(11):1245. doi: 10.1503/cmaj.109-3907. Epub 2011 Jul 11.


PMID- 21746767
OWN - NLM
STAT- MEDLINE
DCOM- 20120223
LR  - 20110812
IS  - 1740-7753 (Electronic)
IS  - 1740-7745 (Linking)
VI  - 8
IP  - 4
DP  - 2011 Aug
TI  - Equipoise should be amended, not abandoned.
PG  - 408-16
LID - 10.1177/1740774511409600 [doi]
AB  - BACKGROUND: Benjamin Freedman has argued in 1987 that before a controlled trial
      is started, there should be 'genuine uncertainty in the expert medical community 
      about the preferred treatment'. Freedman's definition of the concept is
      widespread in clinical research, but has been controversial since its start. Over
      the past decade, the equipoise controversy has become increasingly complex.
      PURPOSE: This article aims: (1) to identify and clarify the main points of
      contention in the equipoise controversy, and (2) to reconcile the opposing views 
      by pointing at areas of overlap between proponents and opponents in the equipoise
      debate. METHODS: We analyze the positions of the leading authors in the equipoise
      debate in the past decade. RESULTS: There is substantial overlap between the
      opponents and proponents of equipoise. Both should be able to accept the
      following answers to points of contention in the debate: (1) the therapeutic
      obligation can remain the basis for equipoise as long as it is conceived as an
      obligation to provide participants with competent care, (2) equipoise is grounded
      in a competent care and an epistemological dilemma, (3) equipoise does not as a
      rule prohibit placebo-controlled trials when proven effective treatment exists,
      (4) patient equipoise and individual physician equipoise are irrelevant, and (5) 
      having to stop a trial is not always equivalent to disturbing equipoise.
      Clarification of these points of contention leads to a sharpened definition of
      equipoise: 'a state of genuine agnosticism or conflict in the expert medical
      community about the net preferred medically established procedure for the
      condition under study'. This definition asks of physician-researchers and members
      of IRBs to meet two conditions: (1) to genuinely evaluate to what extent a
      proposed randomized clinical trial solves a state of agnosticism or a knowledge
      conflict in the expert medical community and (2) to respect the standard of
      competent care, meaning that they consider whether the regular clinical standard 
      from an all-things considered perspective is also the preferred standard in the
      research context. Equipoise is a specification of two general ethical principles 
      for clinical research: scientific validity and a favorable risk benefit ratio. As
      a specification equipoise adds substance to these principles since they do not
      explicitly ask for the two conditions. Equipoise is a prima facie obligation
      rather than a morally authoritative principle for determining the acceptability
      of clinical trials. It needs to be balanced against other norms for clinical
      research. Violation of equipoise is therefore not always unethical. LIMITATIONS: 
      This study is limited to the context of randomized clinical trials. CONCLUSIONS: 
      There is no decisive reason to give up on the equipoise requirement.
FAU - van der Graaf, Rieke
AU  - van der Graaf R
AD  - University Medical Center Utrecht, Julius Center for Health Sciences and Primary 
      Care, Utrecht, The Netherlands. r.vandergraaf@umcutrecht.nl
FAU - van Delden, Johannes J M
AU  - van Delden JJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110711
PL  - England
TA  - Clin Trials
JT  - Clinical trials (London, England)
JID - 101197451
SB  - IM
MH  - Dissent and Disputes
MH  - Professional Role
MH  - Randomized Controlled Trials as Topic/*ethics/methods
MH  - *Therapeutic Equipoise
EDAT- 2011/07/13 06:00
MHDA- 2012/02/24 06:00
CRDT- 2011/07/13 06:00
PHST- 2011/07/13 06:00 [entrez]
PHST- 2011/07/13 06:00 [pubmed]
PHST- 2012/02/24 06:00 [medline]
AID - 1740774511409600 [pii]
AID - 10.1177/1740774511409600 [doi]
PST - ppublish
SO  - Clin Trials. 2011 Aug;8(4):408-16. doi: 10.1177/1740774511409600. Epub 2011 Jul
      11.


PMID- 21745832
OWN - NLM
STAT- MEDLINE
DCOM- 20120828
LR  - 20181201
IS  - 1938-2715 (Electronic)
IS  - 1049-9091 (Linking)
VI  - 29
IP  - 3
DP  - 2012 May
TI  - A comparative efficacy of amitriptyline, gabapentin, and pregabalin in
      neuropathic cancer pain: a prospective randomized double-blind placebo-controlled
      study.
PG  - 177-82
LID - 10.1177/1049909111412539 [doi]
AB  - Neuropathic pain is difficult to diagnose and difficult to treat with certainty. 
      So the aim of the study was to evaluate comparative clinical efficacy of
      pregabaline with amitriptyline and gabapentin in neuropathic cancer pain. A total
      of 120 patients with cancer having severe neuropathic cancer pain were enrolled
      in the study after taking approval from Institutional Ethics Committee and
      divided in to 4 groups: group AT-amitriptyline, group GB-gabapentin, group
      PG-pregabalin, and group PL-placebo. Oral morphine was used for rescue analgesic 
      for continued pain. Pain score (Visual Analogue scale) and secondary outcome
      measures such as intensity of lancinating, dysesthesia, and burning on numerical 
      rating scale, Global satisfaction score (GSS), Eastern Co-operative Oncology
      Group scoring (ECOG), and adverse effects were assessed. At the end of study
      there was significant decrease in pain score in group PG as compared to the other
      groups; group AT (P = .003), group GB (P = .042), and group PL (P = .024).
      Percentage of patients with lancinating pain and dysesthesia were significantly
      less in group PG as compared to groups GB and PL. All the patients in group PL
      needed rescue morphine. After 4 visits, maximum improvement in ECOG scoring and
      GSS scoring was observed in group PG patients. Our results suggested that all
      antineuropathic drugs are effective in relieving cancer-related neuropathic pain.
      There was statistically and clinically significant morphine sparing effect of
      pregabaline in relieving neuropathic cancer pain and neuropathic symptoms as
      compared to other antineuropathic drugs.
FAU - Mishra, Seema
AU  - Mishra S
AD  - Unit of Anaesthesiology, Dr. B. R. Ambedkar, Institute Rotary Cancer Hospital,
      All India Institute of Medical Sciences, New Delhi. mseema17@yahoo.co.in
FAU - Bhatnagar, Sushma
AU  - Bhatnagar S
FAU - Goyal, Gaurav Nirvani
AU  - Goyal GN
FAU - Rana, Shiv Pratap Singh
AU  - Rana SP
FAU - Upadhya, Surjya Prasad
AU  - Upadhya SP
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110710
PL  - United States
TA  - Am J Hosp Palliat Care
JT  - The American journal of hospice & palliative care
JID - 9008229
RN  - 0 (Amines)
RN  - 0 (Analgesics)
RN  - 0 (Cyclohexanecarboxylic Acids)
RN  - 1806D8D52K (Amitriptyline)
RN  - 55JG375S6M (Pregabalin)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - 6CW7F3G59X (Gabapentin)
RN  - 76I7G6D29C (Morphine)
SB  - IM
MH  - Adult
MH  - Amines/*therapeutic use
MH  - Amitriptyline/*therapeutic use
MH  - Analgesics/*therapeutic use
MH  - Analysis of Variance
MH  - Cyclohexanecarboxylic Acids/*therapeutic use
MH  - Double-Blind Method
MH  - Drug Therapy, Combination
MH  - Female
MH  - Gabapentin
MH  - Humans
MH  - Male
MH  - Morphine/therapeutic use
MH  - Neoplasms/*complications
MH  - Neuralgia/*drug therapy/etiology
MH  - Pain Measurement
MH  - Pregabalin
MH  - Prospective Studies
MH  - gamma-Aminobutyric Acid/*analogs & derivatives/therapeutic use
EDAT- 2011/07/13 06:00
MHDA- 2012/08/29 06:00
CRDT- 2011/07/13 06:00
PHST- 2011/07/13 06:00 [entrez]
PHST- 2011/07/13 06:00 [pubmed]
PHST- 2012/08/29 06:00 [medline]
AID - 1049909111412539 [pii]
AID - 10.1177/1049909111412539 [doi]
PST - ppublish
SO  - Am J Hosp Palliat Care. 2012 May;29(3):177-82. doi: 10.1177/1049909111412539.
      Epub 2011 Jul 10.


PMID- 21745246
OWN - NLM
STAT- MEDLINE
DCOM- 20111214
LR  - 20120416
IS  - 1600-0838 (Electronic)
IS  - 0905-7188 (Linking)
VI  - 21
IP  - 4
DP  - 2011 Aug
TI  - The use of platelet-rich plasma in sports medicine: a quick fix or medical
      doctors on shaky ethical ground?
PG  - 493-5
LID - 10.1111/j.1600-0838.2011.01360.x [doi]
FAU - Kjaer, Michael
AU  - Kjaer M
FAU - Bayer, Monika
AU  - Bayer M
LA  - eng
PT  - Editorial
PL  - Denmark
TA  - Scand J Med Sci Sports
JT  - Scandinavian journal of medicine & science in sports
JID - 9111504
SB  - IM
CIN - Scand J Med Sci Sports. 2012 Apr;22(2):147-8. PMID: 22404430
MH  - Athletic Injuries/*therapy
MH  - Humans
MH  - *Platelet-Rich Plasma
MH  - Sports Medicine/*ethics
EDAT- 2011/07/13 06:00
MHDA- 2011/12/15 06:00
CRDT- 2011/07/13 06:00
PHST- 2011/07/13 06:00 [entrez]
PHST- 2011/07/13 06:00 [pubmed]
PHST- 2011/12/15 06:00 [medline]
AID - 10.1111/j.1600-0838.2011.01360.x [doi]
PST - ppublish
SO  - Scand J Med Sci Sports. 2011 Aug;21(4):493-5. doi:
      10.1111/j.1600-0838.2011.01360.x.


PMID- 21745232
OWN - NLM
STAT- MEDLINE
DCOM- 20111110
LR  - 20191210
IS  - 1752-0606 (Electronic)
IS  - 0194-472X (Linking)
VI  - 37
IP  - 3
DP  - 2011 Jul
TI  - Children and psychotropic medication: a cautionary note.
PG  - 299-306
LID - 10.1111/j.1752-0606.2009.00178.x [doi]
AB  - This report addresses how the mental health field is organized in terms of the
      use of psychotropic medications with children and adolescents, and the ethical
      challenge this presents to marriage and family therapists.
CI  - (c) 2011 American Association for Marriage and Family Therapy.
FAU - Morris, James
AU  - Morris J
AD  - Marriage and Family Therapy Program, Texas Tech University,
      USA.james.morris@ttu.edu
FAU - Stone, George
AU  - Stone G
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20091217
PL  - United States
TA  - J Marital Fam Ther
JT  - Journal of marital and family therapy
JID - 7904614
RN  - 0 (Psychotropic Drugs)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Family Therapy/ethics
MH  - Humans
MH  - Marital Therapy
MH  - Mental Disorders/*drug therapy
MH  - Outcome Assessment, Health Care
MH  - Psychotropic Drugs/adverse effects/classification/*therapeutic use
MH  - Risk Assessment
EDAT- 2011/07/13 06:00
MHDA- 2011/11/11 06:00
CRDT- 2011/07/13 06:00
PHST- 2011/07/13 06:00 [entrez]
PHST- 2011/07/13 06:00 [pubmed]
PHST- 2011/11/11 06:00 [medline]
AID - 10.1111/j.1752-0606.2009.00178.x [doi]
PST - ppublish
SO  - J Marital Fam Ther. 2011 Jul;37(3):299-306. doi:
      10.1111/j.1752-0606.2009.00178.x. Epub 2009 Dec 17.


PMID- 21745162
OWN - NLM
STAT- MEDLINE
DCOM- 20120416
LR  - 20111219
IS  - 1473-7760 (Electronic)
IS  - 1052-0295 (Linking)
VI  - 87
IP  - 1
DP  - 2012 Jan
TI  - The NCI Biospecimen Research Network.
PG  - 18-23
LID - 10.3109/10520295.2011.591833 [doi]
AB  - High quality cancer research using human biospecimens must be based on
      biospecimens that have been obtained according to rigorous ethical and procedural
      standards. Methods for biospecimen collection, stabilization, processing and
      storage for research, however, are highly variable and the biospecimens available
      for research often are of unknown quality. The National Cancer Institute
      Biospecimen Research Network program was initiated in 2006 to conduct, sponsor,
      report and collaborate on research to better understand the effects of different 
      biospecimen collection methods on downstream molecular analysis. An online
      Biospecimen Research Database and an annual symposium, Advancing Cancer Research 
      through Biospecimen Science, have been developed and many research projects are
      underway to develop a knowledge base from which to develop evidence-based
      biospecimen standard operating procedures and methods for assessing biospecimen
      quality. These efforts will enable better cancer research and development
      efforts.
FAU - Moore, H M
AU  - Moore HM
AD  - National Cancer Institute, Office of Biorepositories and Biospecimen Research,
      11400 Rockville Pike, Room 700, Bethesda, Maryland 20852, USA.
      moorehe@mail.nih.gov
LA  - eng
PT  - Journal Article
DEP - 20110712
PL  - England
TA  - Biotech Histochem
JT  - Biotechnic & histochemistry : official publication of the Biological Stain
      Commission
JID - 9107378
SB  - IM
MH  - Biological Specimen Banks/*organization & administration/*standards
MH  - Biomedical Research/*methods
MH  - Evidence-Based Medicine/standards
MH  - Humans
MH  - National Cancer Institute (U.S.)
MH  - Neoplasms/diagnosis/pathology
MH  - *Practice Guidelines as Topic
MH  - Quality Control
MH  - Specimen Handling/*standards
MH  - United States
EDAT- 2011/07/13 06:00
MHDA- 2012/04/17 06:00
CRDT- 2011/07/13 06:00
PHST- 2011/07/13 06:00 [entrez]
PHST- 2011/07/13 06:00 [pubmed]
PHST- 2012/04/17 06:00 [medline]
AID - 10.3109/10520295.2011.591833 [doi]
PST - ppublish
SO  - Biotech Histochem. 2012 Jan;87(1):18-23. doi: 10.3109/10520295.2011.591833. Epub 
      2011 Jul 12.


PMID- 21745054
OWN - NLM
STAT- MEDLINE
DCOM- 20111123
LR  - 20110712
IS  - 1532-8015 (Electronic)
IS  - 1040-1334 (Linking)
VI  - 23
IP  - 3
DP  - 2011 Jul-Sep
TI  - Impact of a competency-based curriculum on medical student advancement: a
      ten-year analysis.
PG  - 207-14
LID - 10.1080/10401334.2011.586910 [doi]
AB  - BACKGROUND: In 1999, the Indiana University School of Medicine implemented a new 
      curriculum based on the attainment of core competencies beyond medical knowledge.
      PURPOSE: The objective was to document how the Student Promotions Committee (SPC)
      has adjudicated students' competency-related deficiencies over the past decade.
      METHODS: Using SPC records, the authors determined the frequency of
      competency-related deficiencies reported to the SPC over time, the nature of
      those deficiencies, and how the deficiencies were remediated. For the purposes of
      this study, traditional knowledge-related deficiencies like course failures were 
      excluded from analysis. RESULTS: From 1999 to 2009, 191 students (138 male, 53
      female) were referred to the SPC for competency-related deficiencies in 8
      performance domains involving communication, basic clinical skills, lifelong
      learning, self-awareness, social context, ethics, problem solving, and
      professionalism. By comparison, 1,090 students were referred to the SPC for
      knowledge-related deficiencies during this time. Collectively, the 191 students
      were cited for 317 separate competency-related deficiencies (M +/- SD = 1.7 +/-
      1.3; range = 1-10). Of these 317 deficiencies, the most prevalent were in the
      competencies of professionalism (29.3%), basic clinical skills (28.4%), and
      self-awareness (17.7%). Each of the remaining competencies constituted less than 
      10% of the total. Successful remediation utilized 12 methods ranging from a
      simple warning letter to repeating the year under close monitoring. Remediation
      was unsuccessful for 17 students (8.9%) who were dismissed from medical school
      primarily due to unprofessional behaviors and poor self-awareness. CONCLUSIONS:
      Competency-related deficiencies can be identified and remediated in most cases,
      but deficiencies in professionalism and self-awareness are especially
      challenging.
FAU - Brokaw, James J
AU  - Brokaw JJ
AD  - Admissions and Medical Student Affairs, Indiana University School of Medicine,
      635 Barnhill Drive, Indianapolis, IN 46202, USA. jbrokaw@iupui.edu
FAU - Torbeck, Laura J
AU  - Torbeck LJ
FAU - Bell, Mary A
AU  - Bell MA
FAU - Deal, Dennis W
AU  - Deal DW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Teach Learn Med
JT  - Teaching and learning in medicine
JID - 8910884
SB  - IM
MH  - Clinical Competence/*standards
MH  - Competency-Based Education/*standards
MH  - Curriculum
MH  - Female
MH  - Humans
MH  - Indiana
MH  - Male
MH  - Program Evaluation
MH  - Schools, Medical
MH  - *Students, Medical
EDAT- 2011/07/13 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/13 06:00
PHST- 2011/07/13 06:00 [entrez]
PHST- 2011/07/13 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1080/10401334.2011.586910 [doi]
PST - ppublish
SO  - Teach Learn Med. 2011 Jul-Sep;23(3):207-14. doi: 10.1080/10401334.2011.586910.


PMID- 21744554
OWN - NLM
STAT- MEDLINE
DCOM- 20110718
LR  - 20110708
IS  - 0023-7205 (Print)
IS  - 0023-7205 (Linking)
VI  - 108
IP  - 10
DP  - 2011 Mar 9-15
TI  - [Deactivation of implantable defibrillators--also an ethical issue. Written
      routines of the process are necessary as illustrated by the described case
      report].
PG  - 536-9
FAU - Carlsson, Jorg
AU  - Carlsson J
AD  - Jorg.carlsson@ltkalmar.se
FAU - Mansson, Anders
AU  - Mansson A
FAU - Olsson, David
AU  - Olsson D
LA  - swe
PT  - Case Reports
PT  - Journal Article
TT  - Avstangning av implanterbar defibrillator--ocksa en etisk fraga. Skriftliga
      rutiner behovs, visar beskrivna fall.
PL  - Sweden
TA  - Lakartidningen
JT  - Lakartidningen
JID - 0027707
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cause of Death
MH  - Decision Making/ethics
MH  - Defibrillators, Implantable/adverse effects/*ethics
MH  - Fatal Outcome
MH  - Female
MH  - Heart Failure/therapy
MH  - Humans
MH  - Male
MH  - Medical Futility/*ethics
MH  - Palliative Care/ethics
MH  - Practice Guidelines as Topic
MH  - Risk Factors
MH  - Terminal Care/*ethics
MH  - Withholding Treatment/*ethics
EDAT- 2011/07/13 06:00
MHDA- 2011/07/19 06:00
CRDT- 2011/07/13 06:00
PHST- 2011/07/13 06:00 [entrez]
PHST- 2011/07/13 06:00 [pubmed]
PHST- 2011/07/19 06:00 [medline]
PST - ppublish
SO  - Lakartidningen. 2011 Mar 9-15;108(10):536-9.


PMID- 21744255
OWN - NLM
STAT- MEDLINE
DCOM- 20120209
LR  - 20211020
IS  - 1826-6983 (Electronic)
IS  - 0033-8362 (Linking)
VI  - 116
IP  - 8
DP  - 2011 Dec
TI  - The radiological report... and then what?
PG  - 1153-60
LID - 10.1007/s11547-011-0705-6 [doi]
AB  - The radiology report has always been considered as "the most important step in
      the clinical radiological act". While agreeing with this concept, the author
      emphasises that the report can in no way replace the duty to communicate with the
      patient, as mentioned in Art. 31, Italian Code of Medical Ethics. Italy aside,
      this issue has been thoroughly investigated and debated abroad since the 1970s
      and, in the past as well as more recently, many interesting contributions have
      been published both on the need for verbal communication, particularly in certain
      settings, and on the best manner to approach this task. A recent book published
      in Italy also provides useful advice in this regard. The author hopes that in
      Italy, as in other countries, an extensive debate will give rise to a fuller
      awareness of the issue, thereby providing a range of shared solutions.
FAU - Comino, E
AU  - Comino E
LA  - eng
LA  - ita
PT  - Editorial
DEP - 20110709
PL  - Italy
TA  - Radiol Med
JT  - La Radiologia medica
JID - 0177625
SB  - IM
MH  - Ethics, Medical
MH  - Humans
MH  - Italy
MH  - *Medical Records
MH  - Physician-Patient Relations/*ethics
MH  - Practice Guidelines as Topic
MH  - Radiology/*ethics
MH  - Truth Disclosure/*ethics
EDAT- 2011/07/12 06:00
MHDA- 2012/02/10 06:00
CRDT- 2011/07/12 06:00
PHST- 2010/10/08 00:00 [received]
PHST- 2010/11/18 00:00 [accepted]
PHST- 2011/07/12 06:00 [entrez]
PHST- 2011/07/12 06:00 [pubmed]
PHST- 2012/02/10 06:00 [medline]
AID - 10.1007/s11547-011-0705-6 [doi]
PST - ppublish
SO  - Radiol Med. 2011 Dec;116(8):1153-60. doi: 10.1007/s11547-011-0705-6. Epub 2011
      Jul 9.


PMID- 21744060
OWN - NLM
STAT- MEDLINE
DCOM- 20140626
LR  - 20211020
IS  - 1970-9366 (Electronic)
IS  - 1828-0447 (Linking)
VI  - 8
IP  - 7
DP  - 2013 Oct
TI  - Inadequate cancer pain management in Italian clinical trials.
PG  - 591-4
LID - 10.1007/s11739-011-0658-8 [doi]
AB  - Pain treatment in Italy is far from being optimal. In order to improve this
      situation, the reporting of a complete assessment of pain in the clinical record 
      became compulsory by law. Pain-related cancer protocols (143) were selected from 
      the National Monitoring Centre of Clinical Trials Database and reviewed. Our data
      indicate that pain management is not being reported as it should be: treatment
      has been taken into account in only 36.4% of the protocols, and assessment in
      37.1%. Furthermore, breakthrough cancer pain has never been reported. The main
      aim of cancer therapy is obviously control the disease, however Ethics Committees
      should pay close attention to pain therapy when evaluating clinical protocols.
FAU - Lucenteforte, Ersilia
AU  - Lucenteforte E
AD  - Department of Preclinical and Clinical Pharmacology "M. Aiazzi Mancini", Centre
      for Molecular Medicine (CIMMBA), University of Florence, Viale G. Pieraccini 6,
      50139, Florence, Italy, ersilia.lucenteforte@unifi.it.
FAU - Maggini, Valentina
AU  - Maggini V
FAU - Maione, Raffaella
AU  - Maione R
FAU - Fabbroni, Valentina
AU  - Fabbroni V
FAU - Tomino, Carlo
AU  - Tomino C
FAU - Mugelli, Alessandro
AU  - Mugelli A
LA  - eng
PT  - Journal Article
DEP - 20110709
PL  - Italy
TA  - Intern Emerg Med
JT  - Internal and emergency medicine
JID - 101263418
SB  - IM
MH  - *Clinical Trials as Topic
MH  - Female
MH  - Humans
MH  - Italy
MH  - Male
MH  - Neoplasms/*complications
MH  - Pain/*etiology/*prevention & control
MH  - Pain Management/*methods
MH  - Pain Measurement
EDAT- 2011/07/12 06:00
MHDA- 2014/06/27 06:00
CRDT- 2011/07/12 06:00
PHST- 2011/02/25 00:00 [received]
PHST- 2011/06/21 00:00 [accepted]
PHST- 2011/07/12 06:00 [entrez]
PHST- 2011/07/12 06:00 [pubmed]
PHST- 2014/06/27 06:00 [medline]
AID - 10.1007/s11739-011-0658-8 [doi]
PST - ppublish
SO  - Intern Emerg Med. 2013 Oct;8(7):591-4. doi: 10.1007/s11739-011-0658-8. Epub 2011 
      Jul 9.


PMID- 21743431
OWN - NLM
STAT- MEDLINE
DCOM- 20120309
LR  - 20190608
IS  - 1698-6946 (Electronic)
IS  - 1698-4447 (Linking)
VI  - 16
IP  - 7
DP  - 2011 Nov 1
TI  - Autogenous tooth transplantation: evaluation of pulp tissue regeneration.
PG  - e984-9
AB  - OBJECTIVE: The aim of this study was to assess the pulp survival that occur in
      transplants of autologous teeth, by comparing two surgical techniques: the
      conventional technique (autotransplantation for newly formed alveoli), and an
      alternative technique, (autotransplants for alveoli in the initial phase of
      healing). In each surgical techniques were applied, randomly, either saline
      solution or Emdogain(R). STUDY DESIGN: The study group comprised 26 patents, in
      which 28 teeth were transplanted to recipient sockets prepared mechanically. Of
      the 28 teeth transplanted, 4 were intentional replants, and of the remainer, 11
      had the apex closed and 13 open. The mean age at the time of transplantation was 
      22.34 +/- 8.14 years (mean +/- SD). The transplantation were performed by the
      same operator, with the informed consent of the patient and authorized by the
      ethical committee of the hospital. Clinical and radiological examinations were
      performed during 24 to 65 months (48 +/- 12.96; MED +/- SD), from 10 days, 1
      month, 3 months, 6 months and annually to 5.6 years. RESULTS: Only two
      transplanted teeth were lost, due persistent apical periodontitis, and one
      transplanted patient with open apex missed the treatment. In the teeth with pulp,
      we needed to perform root canal therapy in 9. In the 73% of the teeth with closed
      apex, we needed to perform root canal treatment, with no statistically
      significant difference found among closed apex and root canal therapy (p=0.083). 
      In only 8% of the teeth with open apex did we need to perform root canal
      treatment, with an association between open apex and root canal therapy
      (p=0.0002). The overall success rate was 98% with significant difference for
      losses (p=0.0001). CONCLUSIONS: Although not a frequent procedure, it was
      concluded that autotransplanted teeth, performed with appropriate surgical care
      had a good prognosis, and can render a very useful service to the patients.
FAU - Marques-Ferreira, Manuel
AU  - Marques-Ferreira M
AD  - Departamento de Medicina Dentaria, Hospitais da Universidade de Coimbra, Coimbra,
      Portugal. m.mferreira@netcabo.pt
FAU - Rabaca-Botelho, Maria-Filomena
AU  - Rabaca-Botelho MF
FAU - Carvalho, Lina
AU  - Carvalho L
FAU - Oliveiros, Barbara
AU  - Oliveiros B
FAU - Palmeirao-Carrilho, Eunice-Virginia
AU  - Palmeirao-Carrilho EV
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20111101
PL  - Spain
TA  - Med Oral Patol Oral Cir Bucal
JT  - Medicina oral, patologia oral y cirugia bucal
JID - 101231694
RN  - 0 (Dental Enamel Proteins)
RN  - 0 (enamel matrix proteins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Dental Enamel Proteins/*therapeutic use
MH  - Dental Pulp/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - *Regeneration
MH  - Tooth/*transplantation
MH  - Transplantation, Autologous/methods
MH  - Young Adult
EDAT- 2011/07/12 06:00
MHDA- 2012/03/10 06:00
CRDT- 2011/07/12 06:00
PHST- 2010/03/03 00:00 [received]
PHST- 2011/01/03 00:00 [accepted]
PHST- 2011/07/12 06:00 [entrez]
PHST- 2011/07/12 06:00 [pubmed]
PHST- 2012/03/10 06:00 [medline]
AID - 16926 [pii]
AID - 10.4317/medoral.16926 [doi]
PST - epublish
SO  - Med Oral Patol Oral Cir Bucal. 2011 Nov 1;16(7):e984-9. doi:
      10.4317/medoral.16926.


PMID- 21742951
OWN - NLM
STAT- MEDLINE
DCOM- 20111110
LR  - 20211203
IS  - 1461-7471 (Electronic)
IS  - 1363-4615 (Linking)
VI  - 48
IP  - 3
DP  - 2011 Jul
TI  - Translating Fanon in the Italian context: rethinking the ethics of treatment in
      psychiatry.
PG  - 228-56
LID - 10.1177/1363461511403029 [doi]
AB  - Based on two years of ethnographic fieldwork at the Centro Frantz Fanon, an
      ethnopsychiatric clinic in Northern Italy, this article traces the theoretical
      and clinical genealogy of Italian ethnopsychiatry as it is conceived and
      practiced at this clinic. The clinic draws explicitly from the work of Fanon and 
      French ethnopsychologist Tobie Nathan. This genealogy provides a basis for
      reflection on the ways in which current ethnopsychiatry re-articulates older
      questions about difference and healing, culture and suffering, and the political 
      dimensions of psychiatry. Although ethnopsychiatry is currently focused on the
      care of migrants, key issues related to the impact of colonialism on mental
      illness and the recognition of cultural difference characterized the Italian
      debate long before the 1980s when increasing numbers of migrants and political
      refugees started to arrive in Italy.
FAU - Giordano, Cristiana
AU  - Giordano C
AD  - Department of Anthropology, University of California, 321 Young Hall, One Shields
      Avenue, Davis, CA 95616, USA. cgiordano@ucdavis.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Transcult Psychiatry
JT  - Transcultural psychiatry
JID - 9708119
SB  - IM
MH  - Anthropology, Cultural/ethics/*trends
MH  - Blacks/ethnology/psychology
MH  - Ethnopsychology/*ethics/*trends
MH  - Health Services Accessibility/ethics/trends
MH  - Humans
MH  - Institutionalization/ethics/trends
MH  - Italy/ethnology
MH  - Mental Disorders/diagnosis/psychology/therapy
MH  - Mental Health Services/ethics/*trends
EDAT- 2011/07/12 06:00
MHDA- 2011/11/11 06:00
CRDT- 2011/07/12 06:00
PHST- 2011/07/12 06:00 [entrez]
PHST- 2011/07/12 06:00 [pubmed]
PHST- 2011/11/11 06:00 [medline]
AID - 48/3/228 [pii]
AID - 10.1177/1363461511403029 [doi]
PST - ppublish
SO  - Transcult Psychiatry. 2011 Jul;48(3):228-56. doi: 10.1177/1363461511403029.


PMID- 21742711
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20110711
IS  - 1552-7409 (Electronic)
IS  - 0894-3184 (Linking)
VI  - 24
IP  - 3
DP  - 2011 Jul
TI  - Human dignity: a cornerstone of doctoral education in nursing.
PG  - 209-14
LID - 10.1177/0894318411409425 [doi]
AB  - Human dignity is foundational to nursing ethics in both the practice and
      educational arena. It is implicitly and explicitly woven throughout all ethical
      dialogue. This column offers insight into the ubiquitous nature of human dignity 
      as it surfaced during a doctoral level ethics course. These examples are shared
      in light of the humanbecoming human dignity ethical tenets: reverence, awe,
      betrayal, and shame. The prevalence of dignity in ethical discussion serves as a 
      reminder for nurses to carve out time for meaningful discussions regarding its
      importance to the nursing profession as a whole.
FAU - Condon, Barbara Backer
AU  - Condon BB
AD  - Briar Cliff University, USA.
FAU - Hegge, Margaret
AU  - Hegge M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Nurs Sci Q
JT  - Nursing science quarterly
JID - 8805022
MH  - *Education, Nursing, Graduate
MH  - Ethics, Nursing/*education
MH  - Humans
MH  - *Personhood
EDAT- 2011/07/12 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/07/12 06:00
PHST- 2011/07/12 06:00 [entrez]
PHST- 2011/07/12 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - 24/3/209 [pii]
AID - 10.1177/0894318411409425 [doi]
PST - ppublish
SO  - Nurs Sci Q. 2011 Jul;24(3):209-14. doi: 10.1177/0894318411409425.


PMID- 21742710
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20110711
IS  - 1552-7409 (Electronic)
IS  - 0894-3184 (Linking)
VI  - 24
IP  - 3
DP  - 2011 Jul
TI  - Fostering ethical thoughtfulness.
PG  - 208
LID - 10.1177/0894318411409426 [doi]
FAU - Bunkers, Sandra Schmidt
AU  - Bunkers SS
AD  - Graduate Department, South Dakota State University, Sioux Falls, SD 57105, USA.
      tsbunkers@sio.midco.net
LA  - eng
PT  - Introductory Journal Article
PL  - United States
TA  - Nurs Sci Q
JT  - Nursing science quarterly
JID - 8805022
MH  - Ethics, Nursing/*education
EDAT- 2011/07/12 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/07/12 06:00
PHST- 2011/07/12 06:00 [entrez]
PHST- 2011/07/12 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - 24/3/208 [pii]
AID - 10.1177/0894318411409426 [doi]
PST - ppublish
SO  - Nurs Sci Q. 2011 Jul;24(3):208. doi: 10.1177/0894318411409426.


PMID- 21742709
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20110711
IS  - 1552-7409 (Electronic)
IS  - 0894-3184 (Linking)
VI  - 24
IP  - 3
DP  - 2011 Jul
TI  - Betrayal and academic relationships.
PG  - 206-7
LID - 10.1177/0894318411409438 [doi]
AB  - Betrayal, or the violation of human trust, is an important phenomenon happening
      in nurse-nurse and nurse-other human relationships in healthcare contexts.
      Specifically, betrayal and breaches of trust surface in academic relationships
      cocreating tension and uncertainty. This column begins a discussion of the
      phenomenon as viewed through the lens of the humanbecoming ethical tenets.
FAU - Milton, Constance L
AU  - Milton CL
AD  - California Baptist University, Riverside, CA 92504, USA.
      constancemilton@yahoo.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Nurs Sci Q
JT  - Nursing science quarterly
JID - 8805022
MH  - Humans
MH  - Interprofessional Relations/*ethics
MH  - *Nursing
MH  - *Trust
EDAT- 2011/07/12 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/07/12 06:00
PHST- 2011/07/12 06:00 [entrez]
PHST- 2011/07/12 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - 24/3/206 [pii]
AID - 10.1177/0894318411409438 [doi]
PST - ppublish
SO  - Nurs Sci Q. 2011 Jul;24(3):206-7. doi: 10.1177/0894318411409438.


PMID- 21741774
OWN - NLM
STAT- MEDLINE
DCOM- 20111206
LR  - 20110805
IS  - 1531-6564 (Electronic)
IS  - 0363-5023 (Linking)
VI  - 36
IP  - 8
DP  - 2011 Aug
TI  - Decency, honor, integrity, and the law.
PG  - 1397-402
LID - 10.1016/j.jhsa.2011.04.020 [doi]
AB  - In its guidelines for hand care professionals, the American Society for Surgery
      of the Hand has set the following criteria as guidelines for the ethical hand
      surgeon in the 21st century: decency, honor, and integrity. This article reviews 
      these criteria in detail, relates how they apply in practice, and describes how
      they interact with state and federal law in both legislative and judicial
      aspects. Matters pertaining to informed consent, privacy issues, patient
      autonomy, shared decision making, and conflict of interest are described, and
      recent developments in this area are examined. Are hand surgeons ready for an
      enforceable system of ethics to be handed down by the ASSH or by the government?
CI  - Copyright (c) 2011. Published by Elsevier Inc.
FAU - Rozmaryn, Leo M
AU  - Rozmaryn LM
AD  - The Orthopaedic Center, Rockville, MD 20850, USA. leohanddoc@yahoo.com
LA  - eng
PT  - Journal Article
DEP - 20110713
PL  - United States
TA  - J Hand Surg Am
JT  - The Journal of hand surgery
JID - 7609631
SB  - IM
MH  - Confidentiality/ethics/legislation & jurisprudence
MH  - Conflict of Interest/legislation & jurisprudence
MH  - Decision Making/ethics
MH  - *Ethics, Medical
MH  - *Guidelines as Topic
MH  - Hand/*surgery
MH  - Humans
MH  - Informed Consent/ethics/legislation & jurisprudence
MH  - Personal Autonomy
MH  - Physician-Patient Relations/ethics
MH  - Societies, Medical
MH  - United States
EDAT- 2011/07/12 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/12 06:00
PHST- 2010/10/12 00:00 [received]
PHST- 2011/04/27 00:00 [accepted]
PHST- 2011/07/12 06:00 [entrez]
PHST- 2011/07/12 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0363-5023(11)00691-5 [pii]
AID - 10.1016/j.jhsa.2011.04.020 [doi]
PST - ppublish
SO  - J Hand Surg Am. 2011 Aug;36(8):1397-402. doi: 10.1016/j.jhsa.2011.04.020. Epub
      2011 Jul 13.


PMID- 21741495
OWN - NLM
STAT- MEDLINE
DCOM- 20120305
LR  - 20110909
IS  - 1878-5832 (Electronic)
IS  - 1359-6446 (Linking)
VI  - 16
IP  - 17-18
DP  - 2011 Sep
TI  - Is informed consent necessary for randomized Phase IV 'observational' drug
      studies?
PG  - 751-4
LID - 10.1016/j.drudis.2011.06.007 [doi]
AB  - This article addresses the question about whether informed consent (IC) can be
      waived in Phase IV randomized observational drug studies (P4RODSs). To do this,
      it was first necessary to establish that the term P4RODS is a contradiction
      precisely because randomization necessarily makes a study 'interventional', hence
      P4RIDS. Once this was established we argued that, based on the right and the harm
      principles, universally waiving IC in P4RIDS is ethically unjustifiable. Looking 
      into public health and the nature of equipotent and bioequivalent drugs were also
      insufficient rationale to justify circumstantial waiving of IC. We conclude that 
      IC can never be waived in P4RIDS, although an opt-out procedure in minimal risk
      studies could be ethically acceptable.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Bernabe, Rosemarie D C
AU  - Bernabe RD
AD  - Julius Center for Health Sciences and Primary Care, Utrecht University Medical
      Center, Huispost Str. 6.131, PO Box 85500, 3508 GA Utrecht, The Netherlands.
      r.bernabe@umcutrecht.nl
FAU - van Thiel, Ghislaine J M W
AU  - van Thiel GJ
FAU - Raaijmakers, Jan A M
AU  - Raaijmakers JA
FAU - van Delden, Johannes J M
AU  - van Delden JJ
LA  - eng
PT  - Journal Article
DEP - 20110629
PL  - England
TA  - Drug Discov Today
JT  - Drug discovery today
JID - 9604391
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Clinical Trials, Phase IV as Topic/*ethics
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Pharmaceutical Preparations/administration & dosage
MH  - Public Health/*ethics
MH  - Randomized Controlled Trials as Topic/*ethics
EDAT- 2011/07/12 06:00
MHDA- 2012/03/06 06:00
CRDT- 2011/07/12 06:00
PHST- 2011/03/15 00:00 [received]
PHST- 2011/04/27 00:00 [revised]
PHST- 2011/06/10 00:00 [accepted]
PHST- 2011/07/12 06:00 [entrez]
PHST- 2011/07/12 06:00 [pubmed]
PHST- 2012/03/06 06:00 [medline]
AID - S1359-6446(11)00207-8 [pii]
AID - 10.1016/j.drudis.2011.06.007 [doi]
PST - ppublish
SO  - Drug Discov Today. 2011 Sep;16(17-18):751-4. doi: 10.1016/j.drudis.2011.06.007.
      Epub 2011 Jun 29.


PMID- 21741134
OWN - NLM
STAT- MEDLINE
DCOM- 20120201
LR  - 20191210
IS  - 1768-3122 (Electronic)
IS  - 0248-8663 (Linking)
VI  - 32
IP  - 11
DP  - 2011 Nov
TI  - [Evolution and follow-up of hunger strikers: experience from an interregional
      hospital secured unit].
PG  - 669-77
LID - 10.1016/j.revmed.2011.05.001 [doi]
AB  - PURPOSE: A hunger strike is a voluntary fast, performed to protest publicly
      against an issue deemed unfair. In the case of French prisoners, hospitalization 
      in an interregional hospital secured units (UHSI) may be necessary. METHODS: A
      retrospective epidemiological study based on one UHSI medical records was
      performed on the period of May, 2006 to December, 2008, and focused on symptoms, 
      outcomes and ethical problems encountered. RESULTS: Seven men and one woman with 
      a mean age of 32.6 years were hospitalized in an UHSI, with nine episodes of
      hunger strike of a median duration of 57 days. Clinical symptoms began after two 
      weeks of voluntary deprivation in the form of dizziness, weakness, muscle pain
      and headache. Laboratory tests showed hypoglycemia (<0.4g/L) on admission, 16.3% 
      decrease of albumin after 40.5 days, and dehydration in case of thirst strike.
      The clinical tolerance was good and no patient presented Wernicke's
      encephalopathy. A diabetic patient developed acidocetosis during two hunger
      strikes. All hunger strikes were respected by medical staff, and treatment was
      based upon surveillance of symptoms, vitamin B and sweetened drinks
      administration and explanations of the clinical hazards on a daily basis.
      CONCLUSION: The special problem encountered in the medical management of these
      strikers was to convince them to accept treatments in order to avoid a coercive
      life-saving treatment as requested by French law.
CI  - Copyright (c) 2011 Societe nationale francaise de medecine interne (SNFMI).
      Published by Elsevier SAS. All rights reserved.
FAU - Dubois, F
AU  - Dubois F
AD  - Unite hospitaliere securisee interregionale (UHSI), pole medicojudiciaire, CHU
      Pellegrin, Bordeaux cedex, France.
FAU - Sudre, E
AU  - Sudre E
FAU - Porte, A
AU  - Porte A
FAU - Bedry, R
AU  - Bedry R
FAU - Gromb, S
AU  - Gromb S
LA  - fre
PT  - Evaluation Study
PT  - Journal Article
TT  - Evolution et surveillance des patients grevistes de la faim : experience d'une
      unite hospitaliere securisee interregionale.
DEP - 20110707
PL  - France
TA  - Rev Med Interne
JT  - La Revue de medecine interne
JID - 8101383
SB  - IM
MH  - Adult
MH  - Body Weight/physiology
MH  - Delivery of Health Care/*methods
MH  - Disease Progression
MH  - Fasting/*physiology
MH  - Female
MH  - Follow-Up Studies
MH  - *Hospital Units
MH  - Humans
MH  - Hunger/physiology
MH  - Male
MH  - Nutritional Support/methods/statistics & numerical data
MH  - *Prisoners/statistics & numerical data
MH  - *Prisons
MH  - Retrospective Studies
MH  - Starvation/epidemiology/prevention & control/rehabilitation
MH  - Strikes, Employee/*methods
EDAT- 2011/07/12 06:00
MHDA- 2012/02/02 06:00
CRDT- 2011/07/12 06:00
PHST- 2010/07/08 00:00 [received]
PHST- 2011/05/01 00:00 [revised]
PHST- 2011/05/17 00:00 [accepted]
PHST- 2011/07/12 06:00 [entrez]
PHST- 2011/07/12 06:00 [pubmed]
PHST- 2012/02/02 06:00 [medline]
AID - S0248-8663(11)00555-8 [pii]
AID - 10.1016/j.revmed.2011.05.001 [doi]
PST - ppublish
SO  - Rev Med Interne. 2011 Nov;32(11):669-77. doi: 10.1016/j.revmed.2011.05.001. Epub 
      2011 Jul 7.


PMID- 21740703
OWN - NLM
STAT- MEDLINE
DCOM- 20110823
LR  - 20161125
IS  - 1355-7610 (Print)
IS  - 1355-7610 (Linking)
VI  - 18
IP  - 3
DP  - 2011 Jul
TI  - An introduction to research for primary dental care clinicians part 4: stage 6a. 
      Obtaining ethical approval.
PG  - 127-32
FAU - Santini, Ario
AU  - Santini A
AD  - Edinburgh Postgraduate Dental Institute, University of Edinburgh, UK.
FAU - Eaton, Kenneth A
AU  - Eaton KA
LA  - eng
PT  - Journal Article
PL  - England
TA  - Prim Dent Care
JT  - Primary dental care : journal of the Faculty of General Dental Practitioners (UK)
JID - 9617339
MH  - Confidentiality
MH  - Dental Research/*ethics
MH  - Ethics Committees, Research
MH  - *Ethics, Research
MH  - *General Practice, Dental
MH  - Human Experimentation/ethics
MH  - Humans
MH  - Informed Consent
MH  - United Kingdom
EDAT- 2011/07/12 06:00
MHDA- 2011/08/24 06:00
CRDT- 2011/07/12 06:00
PHST- 2011/07/12 06:00 [entrez]
PHST- 2011/07/12 06:00 [pubmed]
PHST- 2011/08/24 06:00 [medline]
PST - ppublish
SO  - Prim Dent Care. 2011 Jul;18(3):127-32.


PMID- 21740325
OWN - NLM
STAT- MEDLINE
DCOM- 20121121
LR  - 20120626
IS  - 1476-4954 (Electronic)
IS  - 1476-4954 (Linking)
VI  - 25
IP  - 7
DP  - 2012 Jul
TI  - Ethics in neonatology: a look over Europe.
PG  - 984-91
LID - 10.3109/14767058.2011.602442 [doi]
AB  - UNLABELLED: Advances in perinatal medicine have dramatically improved neonatal
      survival. End-of-life decision making for newborns with adverse prognosis is an
      ethical challenge, the ethical issues are controversial and little evidence
      exists on attitudes and values in Europe. OBJECTIVE: to assess the attitudes of
      the neonatal departments in perinatal clinical practice in the hospitals of
      European countries. METHODS: a questionnaire was send to 55 NICUs from 19
      European countries. RESULTS: Forty five (81.8%) NICUs were Level III. Religion
      was Christian in 90.7% and we observed that in north countries the religion is
      more influent on clinical decisions (p = 0.032). Gestational age was considered
      with no significant difference for clinical investment. North countries consider 
      birth weight (p = 0.011) and birth weight plus gestational age (p = 0.024)
      important for clinical investment. In north countries ethical questions should
      not prevail when the decision is made (p = 0.049) and from an ethical point of
      view, there is no difference between withdraw a treatment and do not initiate the
      treatment (p = 0.029). More hospitals in south countries administer any analgesia
      (p = 0.007). When the resuscitation is not successful 96.2% provide comfort care.
      CONCLUSION: Our study reveals that cultural and religious differences influenced 
      ethical attitudes in NICUs of the European countries.
FAU - Guimaraes, Hercilia
AU  - Guimaraes H
AD  - Faculty of Medicine, Porto University, Porto, Portugal.
      herciliaguimaraes@gmail.com
FAU - Rocha, Gustavo
AU  - Rocha G
FAU - Almeda, Filipe
AU  - Almeda F
FAU - Brites, Marta
AU  - Brites M
FAU - Van Goudoever, Johannes B
AU  - Van Goudoever JB
FAU - Iacoponi, Francesca
AU  - Iacoponi F
FAU - Bellieni, Carlo
AU  - Bellieni C
FAU - Buonocore, Giuseppe
AU  - Buonocore G
LA  - eng
PT  - Journal Article
DEP - 20110830
PL  - England
TA  - J Matern Fetal Neonatal Med
JT  - The journal of maternal-fetal & neonatal medicine : the official journal of the
      European Association of Perinatal Medicine, the Federation of Asia and Oceania
      Perinatal Societies, the International Society of Perinatal Obstetricians
JID - 101136916
SB  - IM
MH  - Europe
MH  - Humans
MH  - Infant, Newborn
MH  - Intensive Care Units, Neonatal/*ethics/standards/statistics & numerical data
MH  - Intensive Care, Neonatal/*ethics/standards
MH  - Neonatology/*ethics
MH  - Resuscitation/*standards
EDAT- 2011/07/12 06:00
MHDA- 2012/12/10 06:00
CRDT- 2011/07/12 06:00
PHST- 2011/07/12 06:00 [entrez]
PHST- 2011/07/12 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.3109/14767058.2011.602442 [doi]
PST - ppublish
SO  - J Matern Fetal Neonatal Med. 2012 Jul;25(7):984-91. doi:
      10.3109/14767058.2011.602442. Epub 2011 Aug 30.


PMID- 21739869
OWN - NLM
STAT- MEDLINE
DCOM- 20110727
LR  - 20110711
IS  - 0002-7979 (Print)
IS  - 0002-7979 (Linking)
VI  - 78
IP  - 1
DP  - 2011 Spring
TI  - A case of collegial communication and a patient who does not pay.
PG  - 33-43
AB  - Four individuals who teach ethics in dental schools comment on a case in which
      negative financial information is revealed by one dentist when transferring
      records of a potential patient to another dentist. All commentators find varying 
      degrees of ethical problem with disclosing such information. Professional codes
      discourage this practice. All commentators stress the importance of the potential
      new dentist developing a relationship based on professional standards, with the
      greatest emphasis placed on the patient's health needs. Several of the
      commentators discuss positive ways of conducting a patient interview, including
      specific useful language.
FAU - Peltier, Bruce
AU  - Peltier B
AD  - University of the Pacific, USA. bpeltier@pacific.edu
FAU - Rosenblum, Alvin
AU  - Rosenblum A
FAU - Bebeau, Muriel J
AU  - Bebeau MJ
FAU - Koerber, Anne
AU  - Koerber A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Coll Dent
JT  - The Journal of the American College of Dentists
JID - 7503057
SB  - IM
MH  - Clinical Competence
MH  - Codes of Ethics/classification
MH  - *Communication
MH  - Confidentiality/ethics
MH  - Dental Care/*ethics
MH  - Dental Records
MH  - Dentist-Patient Relations/ethics
MH  - Dentists/*ethics
MH  - Disclosure/ethics
MH  - *Ethics, Dental
MH  - Humans
MH  - Interprofessional Relations/*ethics
MH  - Motivation
MH  - Patient Credit and Collection/ethics
MH  - Patient Transfer/*ethics
MH  - United States
EDAT- 2011/07/12 06:00
MHDA- 2011/07/28 06:00
CRDT- 2011/07/12 06:00
PHST- 2011/07/12 06:00 [entrez]
PHST- 2011/07/12 06:00 [pubmed]
PHST- 2011/07/28 06:00 [medline]
PST - ppublish
SO  - J Am Coll Dent. 2011 Spring;78(1):33-43.


PMID- 21739868
OWN - NLM
STAT- MEDLINE
DCOM- 20110727
LR  - 20110711
IS  - 0002-7979 (Print)
IS  - 0002-7979 (Linking)
VI  - 78
IP  - 1
DP  - 2011 Spring
TI  - Dental students choosing licensure path give more consideration to career
      flexibility rather than ethical dilemmas.
PG  - 24-32
AB  - Although a patient-based clinical licensure examination (CLE) has been used in
      the United States for many decades to evaluate an individual's competency to
      practice dentistry, there continue to be validity, reliability, and ethical
      issues of concern to the profession. As a result of a 2009 decision by the
      Minnesota Board of Dentistry, dental students from the University of Minnesota
      School of Dentistry, beginning with the Class of 2010, are eligible for initial
      licensure in Minnesota by passing the nonpatient-based National Dental Examining 
      Board of Canada Examination. Surveys were distributed to 101 senior dental
      students to assess what factors students used to decide whether or not to
      register for a patient-based CLE. The response rate to the survey was 84.2%
      (85/101). The opportunity to apply for a license in multiple states after passing
      a patient-based CLE was the primary factor in influencing the students to
      register for a patient-based CLE. Regarding the use of live patients in a CLE,
      students were most concerned with having to operatively restore teeth that could 
      be treated more conservatively and for other reasons outside of their control,
      such as the patient failing to show up, patient not being accepted by the
      examiners, and procedural issues during the examination.
FAU - Conrad, Heather J
AU  - Conrad HJ
AD  - Department of Restorative Sciences, University of Minnesota, School of Dentistry,
      USA. conr0094@umn.edu
FAU - Mills, Eric A
AU  - Mills EA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Coll Dent
JT  - The Journal of the American College of Dentists
JID - 7503057
SB  - IM
MH  - Adult
MH  - Attitude
MH  - Career Choice
MH  - *Career Mobility
MH  - Clinical Competence/standards
MH  - Dentist-Patient Relations
MH  - Education, Dental/standards
MH  - *Ethics, Dental
MH  - Female
MH  - Humans
MH  - Internship and Residency
MH  - Licensure, Dental/*classification/ethics
MH  - Male
MH  - Minnesota
MH  - Patient Care Planning
MH  - Professional Practice
MH  - Professional Practice Location
MH  - *Students, Dental
MH  - Young Adult
EDAT- 2011/07/12 06:00
MHDA- 2011/07/28 06:00
CRDT- 2011/07/12 06:00
PHST- 2011/07/12 06:00 [entrez]
PHST- 2011/07/12 06:00 [pubmed]
PHST- 2011/07/28 06:00 [medline]
PST - ppublish
SO  - J Am Coll Dent. 2011 Spring;78(1):24-32.


PMID- 21739748
OWN - NLM
STAT- MEDLINE
DCOM- 20110729
LR  - 20110708
IS  - 0097-9805 (Print)
IS  - 0097-9805 (Linking)
VI  - 37
IP  - 3
DP  - 2011 May-Jun
TI  - The ethical rights of children: yesterday and today.
PG  - 141-4
FAU - Sousa, Custodia
AU  - Sousa C
AD  - Neonatal Intensive Care Unit, Maternidade Dr. Alfredo da Costa, Lisboa, Portugal.
FAU - Araujo, Carina
AU  - Araujo C
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - Pediatr Nurs
JT  - Pediatric nursing
JID - 7505804
MH  - Child
MH  - Child Welfare/*ethics/*history
MH  - History, 17th Century
MH  - History, 18th Century
MH  - History, 19th Century
MH  - History, 20th Century
MH  - History, Ancient
MH  - History, Medieval
MH  - Human Rights
MH  - Humans
EDAT- 2011/07/12 06:00
MHDA- 2011/07/30 06:00
CRDT- 2011/07/12 06:00
PHST- 2011/07/12 06:00 [entrez]
PHST- 2011/07/12 06:00 [pubmed]
PHST- 2011/07/30 06:00 [medline]
PST - ppublish
SO  - Pediatr Nurs. 2011 May-Jun;37(3):141-4.


PMID- 21739674
OWN - NLM
STAT- MEDLINE
DCOM- 20110805
LR  - 20181201
IS  - 0098-1486 (Print)
IS  - 0098-1486 (Linking)
VI  - 43
IP  - 3
DP  - 2011 May-Jun
TI  - The practice of ethics. RNs learn, discuss issues.
PG  - 1, 13, 15
FAU - Trossman, Susan
AU  - Trossman S
LA  - eng
PT  - Congress
PL  - United States
TA  - Am Nurse
JT  - The American nurse
JID - 7506499
MH  - American Nurses' Association
MH  - *Ethics, Nursing
MH  - Humans
MH  - Patient Advocacy/*ethics
MH  - United States
EDAT- 2011/07/09 06:00
MHDA- 2011/08/06 06:00
CRDT- 2011/07/09 06:00
PHST- 2011/07/09 06:00 [entrez]
PHST- 2011/07/09 06:00 [pubmed]
PHST- 2011/08/06 06:00 [medline]
PST - ppublish
SO  - Am Nurse. 2011 May-Jun;43(3):1, 13, 15.


PMID- 21738500
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1662-5145 (Electronic)
IS  - 1662-5145 (Linking)
VI  - 5
DP  - 2011
TI  - Modulating affect, cognition, and behavior - prospects of deep brain stimulation 
      for treatment-resistant psychiatric disorders.
PG  - 29
LID - 10.3389/fnint.2011.00029 [doi]
AB  - Most patients suffering from psychiatric disorders respond to combinations of
      psycho- and psychopharmacotherapy; however there are patients who profit little
      if anything even after many years of treatment. Since about a decade different
      modalities of targeted neuromodulation - among them most prominently - deep brain
      stimulation (DBS) - are being actively researched as putative approaches to very 
      treatment-resistant forms of those disorders. Recently, promising pilot data have
      been reported both for major depression (MD) and obsessive-compulsive disorder
      (OCD). Given the fact that patients included in DBS studies had been treated
      unsuccessfully for many years with conventional treatment methods, renders these 
      findings remarkable. Remarkable is the fact, that in case of the long-term
      studies underway for MD, patients show a stable response. This gives hope to a
      substantial percentage of therapy-resistant psychiatric patients requiring new
      therapy approaches. There are no fundamental ethic objections to its use in
      psychiatric disorders, but until substantial clinical data is available,
      mandatory standards are needed. DBS is a unique and very promising method for the
      treatment of therapy-resistant psychiatric patients. The method allows
      manipulating pathological neuronal networks in a very precise way.
FAU - Schlaepfer, Thomas E
AU  - Schlaepfer TE
AD  - Brain Stimulation Group, Department of Psychiatry and Psychotherapy, University
      of Bonn Bonn, Germany.
FAU - Bewernick, Bettina
AU  - Bewernick B
FAU - Kayser, Sarah
AU  - Kayser S
FAU - Lenz, Diane
AU  - Lenz D
LA  - eng
PT  - Journal Article
DEP - 20110624
PL  - Switzerland
TA  - Front Integr Neurosci
JT  - Frontiers in integrative neuroscience
JID - 101477950
PMC - PMC3125515
OTO - NOTNLM
OT  - deep brain stimulation
OT  - major depression
OT  - obsessive-compulsive disorder
EDAT- 2011/07/09 06:00
MHDA- 2011/07/09 06:01
CRDT- 2011/07/09 06:00
PHST- 2011/01/31 00:00 [received]
PHST- 2011/06/14 00:00 [accepted]
PHST- 2011/07/09 06:00 [entrez]
PHST- 2011/07/09 06:00 [pubmed]
PHST- 2011/07/09 06:01 [medline]
AID - 10.3389/fnint.2011.00029 [doi]
PST - epublish
SO  - Front Integr Neurosci. 2011 Jun 24;5:29. doi: 10.3389/fnint.2011.00029.
      eCollection 2011.


PMID- 21738297
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1525-3252 (Electronic)
IS  - 0899-8280 (Linking)
VI  - 24
IP  - 3
DP  - 2011 Jul
TI  - Can Osler teach us about 21st-century medical ethics?
PG  - 227-35
FAU - Millard, Mark W
AU  - Millard MW
AD  - Baylor Foster Lung Center, Baylor University Medical Center at Dallas.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Proc (Bayl Univ Med Cent)
JT  - Proceedings (Baylor University. Medical Center)
JID - 9302033
CIN - Indian J Med Ethics. 2012 Jan-Mar;9(1):62-3. PMID: 22319859
PMC - PMC3124909
EDAT- 2011/07/09 06:00
MHDA- 2011/07/09 06:01
CRDT- 2011/07/09 06:00
PHST- 2011/07/09 06:00 [entrez]
PHST- 2011/07/09 06:00 [pubmed]
PHST- 2011/07/09 06:01 [medline]
AID - 10.1080/08998280.2011.11928721 [doi]
PST - ppublish
SO  - Proc (Bayl Univ Med Cent). 2011 Jul;24(3):227-35. doi:
      10.1080/08998280.2011.11928721.


PMID- 21738248
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20220321
IS  - 1989-2284 (Electronic)
IS  - 0211-6995 (Linking)
VI  - 31
IP  - 4
DP  - 2011
TI  - Exploring the opinion of CKD patients on dialysis regarding end-of-life and
      Advance Care Planning.
PG  - 449-56
LID - 10.3265/Nefrologia.pre2011.May.10828 [doi]
AB  - Advance care planning (ACP) and the subsequent advance directive document (ADD), 
      previously known as "living wills", have not been widely used in Spain. The
      Ethics Group from the Spanish Society of Nephrology has developed a survey in
      order to investigate the opinion of dialysis patients regarding the ADD and
      end-of-life care. Patients received documentation explaining ACP and filled out a
      survey about their familiarity with and approval of the ADD. Seven hospital
      dialysis centres participated in the study for a total of 416 active dialysis
      patients. Questionnaires were distributed to 263 patients, 154 of which answered 
      (69.2% completed them without assistance). The rates for ADD implementation
      (7.9%) and designation of a representative person (6.6%) were very low. Most of
      the patients clearly expressed their wishes about irreversible coma, vegetative
      state, dementia and untreatable disease. More than 65% did not want mechanical
      ventilation, chronic dialysis, tube feeding or resuscitation if cardiorespiratory
      arrest occurred. They reported that an ADD could be done before starting dialysis
      but most thought that it should be offered only to those who requested it (65% vs
      34%). In conclusion, patients have clear wishes about end-of-life care, although 
      these desires had not been documented due to the very low implementation of the
      ADD.
FAU - Sanchez-Tomero, J A
AU  - Sanchez-Tomero JA
AD  - Servicio de Nefrologia, Hospital Universitario de la Princesa, Diego de Leon 62, 
      Madrid, Spain jsanchez.hlpr@salud.madrid.org
FAU - Rodriguez-Jornet, A
AU  - Rodriguez-Jornet A
FAU - Balda, S
AU  - Balda S
FAU - Cigarran, S
AU  - Cigarran S
FAU - Herrero, J C
AU  - Herrero JC
FAU - Maduell, F
AU  - Maduell F
FAU - Martin, J
AU  - Martin J
FAU - Palomar, R
AU  - Palomar R
CN  - Grupo de Etica y Nefrologia de la S.E.N
LA  - eng
LA  - spa
PT  - Journal Article
PL  - Spain
TA  - Nefrologia
JT  - Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia
JID - 8301215
SB  - IM
MH  - *Advance Care Planning
MH  - Aged
MH  - Attitude to Death
MH  - Comorbidity
MH  - Data Collection
MH  - Female
MH  - Humans
MH  - Kidney Failure, Chronic/*psychology/therapy
MH  - Male
MH  - Middle Aged
MH  - Patient Preference/statistics & numerical data
MH  - Patient Rights
MH  - Peritoneal Dialysis/*psychology
MH  - Renal Dialysis/*psychology
MH  - Spain
MH  - Surveys and Questionnaires
MH  - Terminal Care/*psychology
EDAT- 2011/07/09 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/09 06:00
PHST- 2011/05/16 00:00 [accepted]
PHST- 2011/07/09 06:00 [entrez]
PHST- 2011/07/09 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.3265/Nefrologia.pre2011.May.10828 [doi]
PST - ppublish
SO  - Nefrologia. 2011;31(4):449-56. doi: 10.3265/Nefrologia.pre2011.May.10828.


PMID- 21738027
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20131121
IS  - 1537-162X (Electronic)
IS  - 0362-5664 (Linking)
VI  - 34
IP  - 4
DP  - 2011 Jul-Aug
TI  - When does it end? Attention-deficit/hyperactivity disorder in the middle aged and
      older populations.
PG  - 148-54
LID - 10.1097/WNF.0b013e3182206dc1 [doi]
AB  - BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is estimated to
      affect 4% to 6% of the adult population. In recent years, more and more
      middle-aged and older adults (>55 years) turn to the ADHD unit at Geha Mental
      Health Center suspecting ADHD. Yet, a literature search resulted in very few
      relevant studies. METHODS AND RESULTS: This study, approved by the Geha Mental
      Health Center ethics committee, presents 11 patients, 55 years or older,
      diagnosed and treated by the unit. The patients underwent complete clinical
      evaluation for ADHD according to Diagnostic and Statistical Manual of Mental
      Disorder, Fourth Edition. The data-collection phase included demographic and
      clinical data; Test of Variables of Attention scores used as indicators of
      methylphenidate (MPH) response; Clinical Global Impression scores of both
      severity and improvement were used. Because the sample is very small, allowing
      only limited statistical analyses, nonparametric statistics were used. Eleven
      patients, aged 61.64 +/- 3.87 years (male-female ratio, 9:2), were assessed. The 
      follow-up was conducted for more than 2 months. Fifty-five percent had ADHD,
      predominantly inattentive, and 45% had ADHD combined type. All patients indicated
      suffering (Clinical Global Impression-Severity score range: mild = 27.3%,
      moderate = 45.4%, severe = 27.3%). Fifty-four percent showed at least 1
      psychiatric comorbidity. Test of Variables of Attention scores showed significant
      improvement in 90% (8/9 patients) with MPH dosages similar to those used in
      younger adults. All patients attended the follow-up visits. Ninety-one percent
      (10/11) continued with the medication. Clinical Global Impression-Improvement
      scores showed significant improvement in 73%. No adverse effects were reported.
      CONCLUSIONS: This pilot study described 11 adults 55 years or older, diagnosed
      with ADHD for the first time. Attention-deficit/hyperactivity disorder
      characteristics seemed to persevere; middle aged or older ADHD patients had
      similar clinical-demographic characteristics and a similar response to MPH as
      younger adults. No significant adverse effects were noted.
FAU - Manor, Iris
AU  - Manor I
AD  - Geha mental Health Center, Petah Tikva, Israel. imanor@clalit.org.il
FAU - Rozen, Shlomit
AU  - Rozen S
FAU - Zemishlani, Zvi
AU  - Zemishlani Z
FAU - Weizman, Abraham
AU  - Weizman A
FAU - Zalsman, Gil
AU  - Zalsman G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Neuropharmacol
JT  - Clinical neuropharmacology
JID - 7607910
RN  - 0 (Central Nervous System Stimulants)
RN  - 207ZZ9QZ49 (Methylphenidate)
SB  - IM
MH  - Aged
MH  - Aging/*psychology
MH  - Attention Deficit Disorder with Hyperactivity/drug
      therapy/epidemiology/*physiopathology/psychology
MH  - Central Nervous System Stimulants/adverse effects/therapeutic use
MH  - Comorbidity
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Female
MH  - Follow-Up Studies
MH  - Hospitals, Psychiatric
MH  - Humans
MH  - Israel/epidemiology
MH  - Male
MH  - Medical Records
MH  - Mental Disorders/epidemiology
MH  - Methylphenidate/adverse effects/therapeutic use
MH  - Middle Aged
MH  - Pilot Projects
MH  - Psychiatric Status Rating Scales
MH  - Retrospective Studies
EDAT- 2011/07/09 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/09 06:00
PHST- 2011/07/09 06:00 [entrez]
PHST- 2011/07/09 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1097/WNF.0b013e3182206dc1 [doi]
PST - ppublish
SO  - Clin Neuropharmacol. 2011 Jul-Aug;34(4):148-54. doi:
      10.1097/WNF.0b013e3182206dc1.


PMID- 21737577
OWN - NLM
STAT- MEDLINE
DCOM- 20120201
LR  - 20211020
IS  - 1549-490X (Electronic)
IS  - 1083-7159 (Linking)
VI  - 16
IP  - 8
DP  - 2011
TI  - KRAS and colorectal cancer: ethical and pragmatic issues in effecting real-time
      change in oncology clinical trials and practice.
PG  - 1061-8
LID - 10.1634/theoncologist.2011-0011 [doi]
AB  - Systemic therapy has led to a median survival time for patients with advanced
      colorectal cancer (CRC) almost fourfold longer than that expected with best
      supportive care, an outcome achieved through combining chemotherapeutic and
      targeted biologic agents. Although the latter can include anti-epidermal growth
      factor receptor antibodies, such as cetuximab and panitumumab, we now have strong
      evidence that patients whose tumors harbor mutated KRAS will not benefit from
      this class of agent. Acceptance of the reliability and importance of the KRAS
      data took several years to evolve, however, for a variety of reasons. The
      timeline from the presentation and publication of small, retrospective phase II
      studies to widespread acceptance of the KRAS predictive value and changes in
      behavior-specifically, modifications of ongoing national trials in
      advanced/metastatic CRC, changes in national guidelines and practice patterns,
      and adjustments to the labeled indications for the monoclonal antibodies-was
      lengthy. In this commentary, we discuss whether or not the process of data
      disclosure regarding KRAS status and treatment of advanced CRC patients was
      effective in permitting timely decisions regarding ongoing publicly funded
      clinical trials and whether or not such decisions were rational and ethical. The 
      overall goals are to highlight lessons learned regarding early disclosure of
      clinical trial results, as well as vetting and adoption of new scientific data,
      and to propose modifications for handling similar situations in the future.
FAU - Blanke, Charles D
AU  - Blanke CD
AD  - University of British Columbia and British Columbia Cancer Agency, Vancouver,
      British Columbia, Canada. cblanke@bccancer.bc.ca
FAU - Goldberg, Richard M
AU  - Goldberg RM
FAU - Grothey, Axel
AU  - Grothey A
FAU - Mooney, Margaret
AU  - Mooney M
FAU - Roach, Nancy
AU  - Roach N
FAU - Saltz, Leonard B
AU  - Saltz LB
FAU - Welch, John J
AU  - Welch JJ
FAU - Wood, William A
AU  - Wood WA
FAU - Meropol, Neal J
AU  - Meropol NJ
CN  - NCI GI Steering Committee Colon Cancer Task Force
LA  - eng
PT  - Journal Article
DEP - 20110707
PL  - England
TA  - Oncologist
JT  - The oncologist
JID - 9607837
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antibodies, Monoclonal, Humanized)
RN  - 0 (Antineoplastic Agents)
RN  - 0 (KRAS protein, human)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 6A901E312A (Panitumumab)
RN  - EC 2.7.10.1 (ErbB Receptors)
RN  - EC 3.6.5.2 (Proto-Oncogene Proteins p21(ras))
RN  - EC 3.6.5.2 (ras Proteins)
RN  - PQX0D8J21J (Cetuximab)
SB  - IM
MH  - Antibodies, Monoclonal/therapeutic use
MH  - Antibodies, Monoclonal, Humanized
MH  - Antineoplastic Agents/therapeutic use
MH  - Cetuximab
MH  - Clinical Trials as Topic/*ethics
MH  - *Colorectal Neoplasms/drug therapy/genetics/pathology
MH  - ErbB Receptors/immunology
MH  - Humans
MH  - Medical Oncology/ethics
MH  - Panitumumab
MH  - Practice Patterns, Physicians'/*ethics
MH  - Predictive Value of Tests
MH  - Proto-Oncogene Proteins/*genetics
MH  - Proto-Oncogene Proteins p21(ras)
MH  - Treatment Outcome
MH  - ras Proteins/*genetics
PMC - PMC3228147
IR  - Meropol NJ
FIR - Meropol, Neal J
IR  - Grothey A
FIR - Grothey, Axel
IR  - Alberts SR
FIR - Alberts, Steven R
IR  - Allegra C
FIR - Allegra, Carmen
IR  - Benedetti J
FIR - Benedetti, Jacqueline
IR  - Benson AB 3rd
FIR - Benson, Al B 3rd
IR  - Blanke CD
FIR - Blanke, Charles D
IR  - Chang G
FIR - Chang, George
IR  - Coakley F
FIR - Coakley, Fergus
IR  - Eckhardt SG
FIR - Eckhardt, S Gail
IR  - Ellis LM
FIR - Ellis, Lee M
IR  - Eng C
FIR - Eng, Cathy
IR  - Flynn PJ
FIR - Flynn, Patrick J
IR  - Gill S
FIR - Gill, Sharlene
IR  - Gold PJ
FIR - Gold, Philip J
IR  - Goldberg RM
FIR - Goldberg, Richard M
IR  - Haller DG
FIR - Haller, Daniel G
IR  - Jaffe D
FIR - Jaffe, Deborah
IR  - Jonker D
FIR - Jonker, Derek
IR  - Kachnic LA
FIR - Kachnic, Lisa A
IR  - Mahmoud N
FIR - Mahmoud, Najjia
IR  - Mattrey R
FIR - Mattrey, Robert
IR  - McAllister P
FIR - McAllister, Pam
IR  - Messersmith W
FIR - Messersmith, Wells
IR  - Mooney M
FIR - Mooney, Margaret
IR  - Nelson H
FIR - Nelson, Heidi
IR  - O'Dwyer PJ
FIR - O'Dwyer, Peter J
IR  - Petrelli NJ
FIR - Petrelli, Nicholas J
IR  - Posner MC
FIR - Posner, Mitchell C
IR  - Roach N
FIR - Roach, Nancy
IR  - Ryan D
FIR - Ryan, David
IR  - Sargent DJ
FIR - Sargent, Daniel J
IR  - Shields AF
FIR - Shields, Anthony F
IR  - Sigurdson ER
FIR - Sigurdson, Elin R
IR  - Tepper JE
FIR - Tepper, Joel E
IR  - Welch JJ
FIR - Welch, John J
IR  - Venook AP
FIR - Venook, Alan P
EDAT- 2011/07/09 06:00
MHDA- 2012/02/02 06:00
CRDT- 2011/07/09 06:00
PHST- 2011/07/09 06:00 [entrez]
PHST- 2011/07/09 06:00 [pubmed]
PHST- 2012/02/02 06:00 [medline]
AID - theoncologist.2011-0011 [pii]
AID - 10.1634/theoncologist.2011-0011 [doi]
PST - ppublish
SO  - Oncologist. 2011;16(8):1061-8. doi: 10.1634/theoncologist.2011-0011. Epub 2011
      Jul 7.


PMID- 21737568
OWN - NLM
STAT- MEDLINE
DCOM- 20120209
LR  - 20220316
IS  - 1049-7323 (Print)
IS  - 1049-7323 (Linking)
VI  - 21
IP  - 11
DP  - 2011 Nov
TI  - Interviewing separately or as couples? Considerations of authenticity of method.
PG  - 1576-87
LID - 10.1177/1049732311415288 [doi]
AB  - Heideggerian researchers recognize that people and their worlds are
      coconstructed; people make sense of their world from within it, not detached from
      it. The presence of one's partner in a joint interview will therefore influence
      the experience of participants, and will also influence the descriptions they
      provide. In this article, we present a reflexive discussion of two studies in
      which we used Heideggerian hermeneutic phenomenology to explore people's
      experiences of sexuality and intimacy within the context of their illness. We
      present the Heideggerian concepts of Dasein, authenticity and truth, and draw on 
      extracts from our interview transcripts to exemplify the different effects of
      joint and one-to-one interviews. We also discuss ethical considerations regarding
      these different interview approaches. Heidegger's philosophy does not
      preferentially support either method, but helps us to be clearer about the merits
      and limitations of each approach. Combining both approaches provides richer
      understanding of phenomena.
FAU - Taylor, Bridget
AU  - Taylor B
AD  - Oxford Brookes University, Oxford, United Kingdom. bmtaylor@brookes.ac.uk
FAU - de Vocht, Hilde
AU  - de Vocht H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110707
PL  - United States
TA  - Qual Health Res
JT  - Qualitative health research
JID - 9202144
MH  - *Family Characteristics
MH  - Humans
MH  - Interpersonal Relations
MH  - Interview, Psychological/*methods
MH  - Models, Psychological
MH  - *Psychological Theory
MH  - *Qualitative Research
MH  - *Research Design
MH  - Sexuality/psychology
MH  - Trust/psychology
EDAT- 2011/07/09 06:00
MHDA- 2012/02/10 06:00
CRDT- 2011/07/09 06:00
PHST- 2011/07/09 06:00 [entrez]
PHST- 2011/07/09 06:00 [pubmed]
PHST- 2012/02/10 06:00 [medline]
AID - 1049732311415288 [pii]
AID - 10.1177/1049732311415288 [doi]
PST - ppublish
SO  - Qual Health Res. 2011 Nov;21(11):1576-87. doi: 10.1177/1049732311415288. Epub
      2011 Jul 7.


PMID- 21737320
OWN - NLM
STAT- MEDLINE
DCOM- 20111213
LR  - 20110808
IS  - 1532-2971 (Electronic)
IS  - 1090-0233 (Linking)
VI  - 189
IP  - 2
DP  - 2011 Aug
TI  - Researcher responsibilities and genetic counseling for pure-bred dog populations.
PG  - 234-5
LID - 10.1016/j.tvjl.2011.06.025 [doi]
AB  - Breeders of dogs have ethical responsibilities regarding the testing and
      management of genetic disease. Molecular genetics researchers have their own
      responsibilities, highlighted in this article. Laboratories offering commercial
      genetic testing should have proper sample identification and quality control,
      official test result certificates, clear explanations of test results and
      reasonably priced testing fees. Providing test results to a publicly-accessible
      genetic health registry allows breeders and the public to search for
      health-tested parents to reduce the risk of producing or purchasing affected
      offspring. Counseling on the testing and elimination of defective genes must
      consider the effects of genetic selection on the population. Recommendations to
      breed quality carriers to normal-testing dogs and replacing them with quality
      normal-testing offspring will help to preserve breeding lines and breed genetic
      diversity.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Bell, Jerold S
AU  - Bell JS
AD  - Department of Clinical Sciences, Tufts Cummings School of Veterinary Medicine,
      North Grafton, MA 01536, USA. jerold.bell@tufts.edu
LA  - eng
PT  - Journal Article
DEP - 20110706
PL  - England
TA  - Vet J
JT  - Veterinary journal (London, England : 1997)
JID - 9706281
SB  - IM
MH  - Animals
MH  - *Breeding
MH  - Dogs/*genetics
MH  - Female
MH  - Genetic Counseling/ethics
MH  - Genetic Research/*ethics
MH  - Genetic Testing/*veterinary
MH  - Male
MH  - Molecular Biology/ethics
EDAT- 2011/07/09 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/07/09 06:00
PHST- 2011/07/09 06:00 [entrez]
PHST- 2011/07/09 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - S1090-0233(11)00239-5 [pii]
AID - 10.1016/j.tvjl.2011.06.025 [doi]
PST - ppublish
SO  - Vet J. 2011 Aug;189(2):234-5. doi: 10.1016/j.tvjl.2011.06.025. Epub 2011 Jul 6.


PMID- 21736860
OWN - NLM
STAT- MEDLINE
DCOM- 20111205
LR  - 20110715
IS  - 1471-6348 (Electronic)
IS  - 0266-4623 (Linking)
VI  - 27
IP  - 3
DP  - 2011 Jul
TI  - Tackling ethical issues in health technology assessment: a proposed framework.
PG  - 230-7
LID - 10.1017/S0266462311000250 [doi]
AB  - OBJECTIVES: Values are intrinsic to the use of health technology assessments
      (HTAs) in health policy, but neglecting value assumptions in HTA makes their
      results appear more robust or normatively neutral than may be the case. Results
      of a 2003 survey by the International Network of Agencies for Health Technology
      Assessment (INAHTA) revealed the existence of disparate methods for making values
      and ethical issues explicit when conducting HTA. METHODS: An Ethics Working
      Group, with representation from sixteen agencies, was established to develop a
      framework for addressing ethical issues in HTA. Using an iterative approach, with
      email exchanges and face-to-face workshops, a report on Handling Ethical Issues
      was produced. RESULTS: This study describes the development process and the
      agreed upon framework for reflexive ethical analysis that aims to uncover and
      explore the ethical implications of technologies through an integrated,
      context-sensitive approach and situates the proposed framework within previous
      work in the development of ethics analysis in HTA. CONCLUSIONS: It is important
      that methodological approaches to address ethical reflection in HTA be
      integrative and context sensitive. The question-based approach described and
      recommended here is meant to elicit this type of reflection in a way that can be 
      used by HTA agencies. The questions proposed are considered only as a starting
      point for handling ethics issues, but their use would represent a significant
      improvement over much of the existing practice.
FAU - Burls, Amanda
AU  - Burls A
AD  - University of Oxford and Oxfordshire Primary Care Trust.
      Amanda.Burls@phc.ox.ac.uk
FAU - Caron, Lorraine
AU  - Caron L
FAU - Cleret de Langavant, Ghislaine
AU  - Cleret de Langavant G
FAU - Dondorp, Wybo
AU  - Dondorp W
FAU - Harstall, Christa
AU  - Harstall C
FAU - Pathak-Sen, Ela
AU  - Pathak-Sen E
FAU - Hofmann, Bjorn
AU  - Hofmann B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110708
PL  - England
TA  - Int J Technol Assess Health Care
JT  - International journal of technology assessment in health care
JID - 8508113
SB  - IM
MH  - Education
MH  - *Group Processes
MH  - Humans
MH  - Technology Assessment, Biomedical/*ethics
EDAT- 2011/07/09 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/09 06:00
PHST- 2011/07/09 06:00 [entrez]
PHST- 2011/07/09 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0266462311000250 [pii]
AID - 10.1017/S0266462311000250 [doi]
PST - ppublish
SO  - Int J Technol Assess Health Care. 2011 Jul;27(3):230-7. doi:
      10.1017/S0266462311000250. Epub 2011 Jul 8.


PMID- 21736249
OWN - NLM
STAT- MEDLINE
DCOM- 20120105
LR  - 20161215
IS  - 0022-0124 (Print)
IS  - 0022-0124 (Linking)
VI  - 42
IP  - 11
DP  - 2011 Nov
TI  - Educating nurses about research ethics and practices with a self-directed
      practice-based learning program.
PG  - 516-21
LID - 10.3928/00220124-20110701-02 [doi]
AB  - Learner-driven and practice-based education programs are recommended for
      integration of learning. A continuing education program on research ethics was
      introduced to five nurses in an ambulatory care setting at a Magnet(R) hospital, 
      using a commercially available web-based course followed by a research practicum.
      The seasoned nurses reported little previous education in this area. Working with
      a nurse researcher, three nurses participated in a research project for improving
      clinic care delivery. The success of the continuing education program was
      determined by knowledge acquisition, satisfaction with learning activities, and
      perceived confidence in research participation. This continuing education program
      was effective in providing for knowledge and skill development in research
      ethics. The integrative learning format was well received.
CI  - Copyright 2011, SLACK Incorporated.
FAU - Cibulka, Nancy J
AU  - Cibulka NJ
AD  - School of Nursing, Saint Louis University, St Louis, MO 63104, USA.
      cibulkan@slu.edu
LA  - eng
PT  - Journal Article
DEP - 20110708
PL  - United States
TA  - J Contin Educ Nurs
JT  - Journal of continuing education in nursing
JID - 0262321
MH  - Education, Nursing, Continuing/*methods/*organization & administration
MH  - Ethics, Nursing/*education
MH  - Humans
MH  - Nursing Evaluation Research
MH  - Nursing Staff/education
MH  - Self-Evaluation Programs/*methods/*organization & administration
EDAT- 2011/07/09 06:00
MHDA- 2012/01/06 06:00
CRDT- 2011/07/09 06:00
PHST- 2011/01/02 00:00 [received]
PHST- 2011/05/31 00:00 [accepted]
PHST- 2011/07/09 06:00 [entrez]
PHST- 2011/07/09 06:00 [pubmed]
PHST- 2012/01/06 06:00 [medline]
AID - 10.3928/00220124-20110701-02 [doi]
PST - ppublish
SO  - J Contin Educ Nurs. 2011 Nov;42(11):516-21. doi: 10.3928/00220124-20110701-02.
      Epub 2011 Jul 8.


PMID- 21736228
OWN - NLM
STAT- MEDLINE
DCOM- 20110804
LR  - 20150602
IS  - 2158-7833 (Print)
IS  - 2158-7833 (Linking)
VI  - 40
IP  - 6
DP  - 2011 Jun
TI  - Hidden crisis: Ethics breakdown in Massachusetts.
PG  - 31-6
FAU - Forgues, Mark
AU  - Forgues M
AD  - Medical Resources Group, LLC, USA. mforgues@mit.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - EMS World
JT  - EMS world
JID - 101547538
MH  - Certification/*ethics/standards
MH  - Emergency Medical Technicians/*ethics/standards
MH  - Ethics, Professional/*education
MH  - Fraud/ethics
MH  - Health Education/methods/standards
MH  - Humans
MH  - Massachusetts
EDAT- 2011/07/09 06:00
MHDA- 2011/08/05 06:00
CRDT- 2011/07/09 06:00
PHST- 2011/07/09 06:00 [entrez]
PHST- 2011/07/09 06:00 [pubmed]
PHST- 2011/08/05 06:00 [medline]
PST - ppublish
SO  - EMS World. 2011 Jun;40(6):31-6.


PMID- 21736137
OWN - NLM
STAT- MEDLINE
DCOM- 20110805
LR  - 20151119
IS  - 0193-7758 (Print)
IS  - 0193-7758 (Linking)
VI  - 33
IP  - 3
DP  - 2011 May-Jun
TI  - Off the beaten path: conducting ethical pragmatic trials with marginalized
      populations.
PG  - 6-11
FAU - Silva, Diego S
AU  - Silva DS
AD  - Dalla Lana School of Public Health, Joint Centre for Bioethics, University of
      Toronto, ON, Canada.
FAU - Goering, Paula N
AU  - Goering PN
FAU - Jacobson, Nora
AU  - Jacobson N
FAU - Streiner, David L
AU  - Streiner DL
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - IRB
JT  - IRB
JID - 7906878
SB  - IM
MH  - Canada
MH  - Clinical Trials as Topic/*ethics
MH  - Health Promotion/*ethics
MH  - *Homeless Persons
MH  - Housing
MH  - Humans
MH  - Mental Disorders/*rehabilitation
MH  - *Risk Management/methods/organization & administration
MH  - Social Support
MH  - *Vulnerable Populations
EDAT- 2011/07/09 06:00
MHDA- 2011/08/06 06:00
CRDT- 2011/07/09 06:00
PHST- 2011/07/09 06:00 [entrez]
PHST- 2011/07/09 06:00 [pubmed]
PHST- 2011/08/06 06:00 [medline]
PST - ppublish
SO  - IRB. 2011 May-Jun;33(3):6-11.


PMID- 21735792
OWN - NLM
STAT- MEDLINE
DCOM- 20120508
LR  - 20181201
IS  - 1002-1892 (Print)
IS  - 1002-1892 (Linking)
VI  - 25
IP  - 6
DP  - 2011 Jun
TI  - [Research progress of biological characteristics and advantages of Wharton's
      jelly-mesenchymal stem cells].
PG  - 745-9
AB  - OBJECTIVE: To summarize the research progress of biological characteristics and
      advantages of Wharton's jelly-mesenchymal stem cells (WJ-MSCs). METHODS: The
      related literature on the biological characteristics of WJ-MSCs, umbilical cord
      blood MSCs (UBMSCs) and bone marrow MSCs (BMSCs) was extensively reviewed and
      analyzed. RESULTS: A large number of MSCs which are able to self-replicate,
      self-renew and have high proliferation and multipotent differentiation can be
      isolated from the Wharton's jelly of umbilical cord. WJ-MSCs have many advantages
      in isolation time, isolation efficiency, expansion time, passage capacity,
      expansion capacity when compared with UBMSCs and BMSCs. CONCLUSION: WJ-MSCs have 
      numerous advantages of convenient and abundant sources, relatively pure,
      non-ethical issues, and so on, which can be used for cell transplant therapy,
      gene therapy, and the ideal seed cells of building tissue engineered organ, so
      they provide new ideas for tissue regeneration repair and reconstruction.
FAU - Liu, Lingying
AU  - Liu L
AD  - Department of Burn and Plastic Surgery, First Affiliated Hospital, General
      Hospital of Chinese PLA, Beijing 100048, PR China.
FAU - Chai, Jiake
AU  - Chai J
FAU - Han, Yanfu
AU  - Han Y
FAU - Sun, Tianjun
AU  - Sun T
FAU - Li, Dongjie
AU  - Li D
FAU - Zhao, Jingyu
AU  - Zhao J
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - China
TA  - Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
JT  - Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi =
      Chinese journal of reparative and reconstructive surgery
JID - 9425194
SB  - IM
MH  - Cell Differentiation
MH  - Cells, Cultured
MH  - Humans
MH  - Mesenchymal Stem Cells/*cytology
MH  - Tissue Engineering/*methods
MH  - Umbilical Cord/*cytology
EDAT- 2011/07/09 06:00
MHDA- 2012/05/09 06:00
CRDT- 2011/07/09 06:00
PHST- 2011/07/09 06:00 [entrez]
PHST- 2011/07/09 06:00 [pubmed]
PHST- 2012/05/09 06:00 [medline]
PST - ppublish
SO  - Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2011 Jun;25(6):745-9.


PMID- 21735760
OWN - NLM
STAT- MEDLINE
DCOM- 20110929
LR  - 20190907
IS  - 1678-4561 (Electronic)
IS  - 1413-8123 (Linking)
VI  - 16
IP  - 4
DP  - 2011 Apr
TI  - [Ethical issues of the research with psychiatric drugs].
PG  - 2045-6; author reply 2048-9
FAU - Rego, Marisa Palacios da Cunha e Melo de Almeida
AU  - Rego MP
AD  - Instituto de Estudos em Saude Coletiva, Universidade Federal do Rio de Janeiro,
      Brazil. marisa.palacios@gmail.com
LA  - por
PT  - Comment
PT  - Journal Article
TT  - Aspectos eticos da pesquisa com medicamentos psiquiatricos.
PL  - Brazil
TA  - Cien Saude Colet
JT  - Ciencia & saude coletiva
JID - 9713483
RN  - 0 (Psychotropic Drugs)
SB  - IM
CON - Cien Saude Colet. 2011 Apr;16(4):2035-44. PMID: 21584444
MH  - *Bioethical Issues
MH  - Biomedical Research/*ethics
MH  - Humans
MH  - Psychotropic Drugs/*therapeutic use
EDAT- 2011/07/09 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/07/09 06:00
PHST- 2011/07/09 06:00 [entrez]
PHST- 2011/07/09 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - 10.1590/s1413-81232011000400003 [doi]
PST - ppublish
SO  - Cien Saude Colet. 2011 Apr;16(4):2045-6; author reply 2048-9. doi:
      10.1590/s1413-81232011000400003.


PMID- 21735435
OWN - NLM
STAT- MEDLINE
DCOM- 20110802
LR  - 20220403
IS  - 1469-493X (Electronic)
IS  - 1361-6137 (Linking)
IP  - 7
DP  - 2011 Jul 6
TI  - Immediate versus delayed reconstruction following surgery for breast cancer.
PG  - CD008674
LID - 10.1002/14651858.CD008674.pub2 [doi]
AB  - BACKGROUND: Breast cancer is the most prevalent cancer in women and has a
      lifetime incidence of one in nine in the UK. Curative treatment requires surgery,
      and may involve adjuvant and neo-adjuvant therapy. In many women, post-mastectomy
      breast reconstruction is essential to restore body image and improve quality of
      life. Timing of reconstruction may be immediately at the time of mastectomy or
      delayed until after surgery. Outcomes such as psychosocial morbidity, aesthetics 
      and complications rates may differ between the two approaches. OBJECTIVES: To
      assess the effects of immediate versus delayed reconstruction following surgery
      for breast cancer. SEARCH STRATEGY: We searched the Cochrane Breast Cancer Group 
      (CBCG) Specialised Register on 22 July 2010, MEDLINE from July 2008 to 26 August 
      2010, EMBASE from 2008 to 26 August 2010 and the WHO International Clinical
      Trials Registry Platform (ICTRP) on 26 August 2010. SELECTION CRITERIA:
      Randomised controlled trials (RCTs) comparing immediate breast reconstruction
      versus delayed or no reconstruction in women in any age group and stage of breast
      cancer. We considered any recognised methods of reconstruction to one or both
      breasts undertaken at the same time as mastectomy or at any time following
      mastectomy. DATA COLLECTION AND ANALYSIS: Two review authors independently
      screened papers, extracted trial details and assessed the risk of bias in the one
      eligible study. MAIN RESULTS: We included only one RCT that involved that
      involved 64 women.We judged this study as being at a high risk of bias.
      Post-operative morbidity and mortality were not addressed, and secondary outcomes
      of patient cosmetic evaluations and psychosocial well-being post-reconstruction
      were inadequately reported. Based on limited data there was some, albeit
      unreliable, evidence that immediate reconstruction compared with delayed or no
      reconstruction, reduced psychiatric morbidity reported three months
      post-operatively. AUTHORS' CONCLUSIONS: The current level of evidence for the
      effectiveness of immediate versus delayed reconstruction following surgery for
      breast cancer was based on a single RCT with methodological flaws and a high risk
      of bias, which does not allow confident decision-making about choice between
      these surgical options. Until high quality evidence is available, clinicians may 
      wish to consider the recommendations of relevant guidelines and protocols.
      Although the limitations and ethical constraints of conducting RCTs in this field
      are recognised, adequately powered controlled trials with a focus on clinical and
      psychological outcomes are still required. Given the paucity of RCTs in this
      subject, in future versions of this review we will look at study designs other
      than RCTs specifically good quality cohort and case-controlstudies.
FAU - D'Souza, Nigel
AU  - D'Souza N
AD  - Oxford Deanery, Heatherwood and Wexham Park Hospitals NHS Trust, Wexham Park
      Hospital, Slough, Berkshire, UK, SL2 4HL.
FAU - Darmanin, Geraldine
AU  - Darmanin G
FAU - Fedorowicz, Zbys
AU  - Fedorowicz Z
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20110706
PL  - England
TA  - Cochrane Database Syst Rev
JT  - The Cochrane database of systematic reviews
JID - 100909747
SB  - IM
MH  - Breast Neoplasms/psychology/*surgery
MH  - Female
MH  - Humans
MH  - Mammaplasty/*methods/psychology
MH  - Randomized Controlled Trials as Topic
MH  - Time Factors
PMC - PMC8973930
EDAT- 2011/07/08 06:00
MHDA- 2011/08/04 06:00
CRDT- 2011/07/08 06:00
PHST- 2011/07/08 06:00 [entrez]
PHST- 2011/07/08 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
AID - 10.1002/14651858.CD008674.pub2 [doi]
PST - epublish
SO  - Cochrane Database Syst Rev. 2011 Jul 6;(7):CD008674. doi:
      10.1002/14651858.CD008674.pub2.


PMID- 21734583
OWN - NLM
STAT- MEDLINE
DCOM- 20111220
LR  - 20110811
IS  - 1751-4266 (Electronic)
IS  - 1751-4258 (Linking)
VI  - 5
IP  - 3
DP  - 2011 Sep
TI  - Palliative sedation: ethical perspectives from Latin America in comparison with
      European recommendations.
PG  - 279-84
LID - 10.1097/SPC.0b013e3283492acd [doi]
AB  - PURPOSE OF REVIEW: Palliative sedation is a standard procedure used in palliative
      care especially for patients at the very end of their lives, who are enduring
      otherwise intractable suffering. It consists of the administration of sedatives
      and, when necessary, other drugs, usually by infusion, either subcutaneously or
      intravenously, at the necessary rate to achieve the patient's relief, by means of
      reducing the consciousness of the patient. If this administration is not
      discontinued, the usual outcome is the patient's death. So, the most frequent
      criticisms regarding the procedure are those that consider it as a form of
      euthanasia. The intention of the review is analyzing the status questionis in
      Europe and Latin America. RECENT FINDINGS: Current thinking and research about
      this issue refers especially to the terminology, the boundaries between
      palliative sedation and slow euthanasia, especially in pediatric settings, the
      lacking of precise definition for concepts such as refractory symptoms and
      unbearable suffering, and the place for existential suffering in this context;
      the ethical positioning of Latin-American normative and authors is similar to
      that of Europe. SUMMARY: It does not seem that solution to the conflicting points
      will come from better guidelines or more experts' meetings. Instead, efforts
      should be directed to reinforce moral, professional integrity, within the
      framework of an ethics of virtue, as inherent to palliative care. Such ethics can
      effectively be taught and infused, and then required to all healthcare
      professionals.
FAU - Manzini, Jorge L
AU  - Manzini JL
AD  - Hospital Privado de Comunidad, Mar del Plata, National Academy of Medicine,
      Buenos Aires, Argentina. urska.lunder@klinika-golnik.si
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Support Palliat Care
JT  - Current opinion in supportive and palliative care
JID - 101297402
RN  - 0 (Hypnotics and Sedatives)
SB  - IM
MH  - Conscious Sedation/*methods
MH  - Consciousness
MH  - *Ethics, Medical
MH  - Europe
MH  - Euthanasia, Passive/ethics
MH  - Humans
MH  - Hypnotics and Sedatives/administration & dosage
MH  - Latin America
MH  - Neoplasms/*psychology
MH  - Palliative Care/ethics/*methods
MH  - Quality of Life/*psychology
MH  - Stress, Psychological/*psychology
EDAT- 2011/07/08 06:00
MHDA- 2011/12/21 06:00
CRDT- 2011/07/08 06:00
PHST- 2011/07/08 06:00 [entrez]
PHST- 2011/07/08 06:00 [pubmed]
PHST- 2011/12/21 06:00 [medline]
AID - 10.1097/SPC.0b013e3283492acd [doi]
PST - ppublish
SO  - Curr Opin Support Palliat Care. 2011 Sep;5(3):279-84. doi:
      10.1097/SPC.0b013e3283492acd.


PMID- 21734557
OWN - NLM
STAT- MEDLINE
DCOM- 20120123
LR  - 20110826
IS  - 1538-943X (Electronic)
IS  - 1058-2916 (Linking)
VI  - 57
IP  - 5
DP  - 2011 Sep-Oct
TI  - Timing of heparin and perfusion temperature during procurement of organs with
      extracorporeal support in donors after circulatory determination of death.
PG  - 368-74
LID - 10.1097/MAT.0b013e318227f8a2 [doi]
AB  - Despite successful resuscitation of donors after circulatory determination of
      death (DCD) with extracorporeal support (ECS), the technique is limited by
      ethical concerns about donor management (heparinization) and the complexity to
      operate the ECS circuit. This work studies different timing of heparin
      administration and the effects of ECS-perfusion temperature. Cardiac arrest (CA) 
      was induced in swine. Heparin studies, three groups: 1) PRE5, heparin 5 minutes
      before CA; 2) POST5, heparin 5 minutes after CA, plus 2 minutes external chest
      compressions; and 3) POST30, heparin with the initiation of ECS after 30 minutes 
      CA. Perfusion temperature study, two groups: 1) normothermic, ECS-38.5 degrees C 
      after 30 minutes CA and 2) room temperature, ECS-25.5 degrees C for the first 90 
      minutes, followed by ECS-38.5 degrees C. Heparin studies: ECS target flows (>50
      ml/kg/min) were not achieved in the POST30 group, affecting local organ perfusion
      as observed with poor bile (<4 ml/min) and urine output (<25 ml/min), when
      compared with the other groups (normal values). Temperature study: In both
      groups, ECS target flows were reached, and urine/bile output was restored.
      Heparinization 5 minutes after CA is equivalent to premortem heparinization in
      this ECS-DCD model. Heparinization after CA could reduce ethical concerns. Donors
      after circulatory determination of death were successfully resuscitated at both
      temperatures, suggesting that the heat exchanger/water heater can be removed to
      simplify the ECS circuit.
FAU - Rojas-Pena, Alvaro
AU  - Rojas-Pena A
AD  - Division of Transplantation, General Surgery Department, University of Michigan
      Health System, Ann Arbor, Michigan, USA. alvaror@umich.edu
FAU - Hall, Candice M
AU  - Hall CM
FAU - Cook, Keith E
AU  - Cook KE
FAU - Bartlett, Robert H
AU  - Bartlett RH
FAU - Arenas, Juan D
AU  - Arenas JD
FAU - Punch, Jeffrey D
AU  - Punch JD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - ASAIO J
JT  - ASAIO journal (American Society for Artificial Internal Organs : 1992)
JID - 9204109
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Animals
MH  - Cardiopulmonary Resuscitation/methods
MH  - Death
MH  - Extracorporeal Circulation
MH  - Heart Arrest/*therapy
MH  - Heparin/*therapeutic use
MH  - Humans
MH  - Perfusion
MH  - Swine
MH  - Temperature
MH  - Time Factors
MH  - *Tissue Donors
MH  - Tissue and Organ Harvesting/*methods
EDAT- 2011/07/08 06:00
MHDA- 2012/01/24 06:00
CRDT- 2011/07/08 06:00
PHST- 2011/07/08 06:00 [entrez]
PHST- 2011/07/08 06:00 [pubmed]
PHST- 2012/01/24 06:00 [medline]
AID - 10.1097/MAT.0b013e318227f8a2 [doi]
PST - ppublish
SO  - ASAIO J. 2011 Sep-Oct;57(5):368-74. doi: 10.1097/MAT.0b013e318227f8a2.


PMID- 21734225
OWN - NLM
STAT- MEDLINE
DCOM- 20120209
LR  - 20161125
IS  - 1049-7323 (Print)
IS  - 1049-7323 (Linking)
VI  - 21
IP  - 11
DP  - 2011 Nov
TI  - Interviews on end-of-life care with older people: reflections on six european
      studies.
PG  - 1588-600
LID - 10.1177/1049732311415286 [doi]
AB  - Qualitative research provides important insights into the experiences and
      perspectives of older people on end-of-life issues, but such research is
      methodologically and ethically complex. We offer a set of reflections from six
      end-of-life care studies conducted with older people in four European countries: 
      Belgium, Germany, the Netherlands, and the United Kingdom. The reflection process
      was informed by four full-day meetings between the authors and referral to
      sources including the study interview guides, summary "pen portraits" about key
      issues encountered in the interviews, and key sections of the interview
      transcripts. We identified as major challenges accessing people, the introduction
      of end-of-life issues in an interview, managing emotions, the presence of
      companions, and reciprocity. Formal ethical review committees rarely take into
      account these complex issues. We concluded that is it necessary to maintain an
      ongoing reflexive stance to enhance qualitative research practice in the
      intersecting fields of aging and end-of-life studies.
FAU - Pleschberger, Sabine
AU  - Pleschberger S
AD  - University of Klagenfurt, Vienna, Austria. sabine.pleschberger@aau.at
FAU - Seymour, Jane E
AU  - Seymour JE
FAU - Payne, Sheila
AU  - Payne S
FAU - Deschepper, Reginald
AU  - Deschepper R
FAU - Onwuteaka-Philipsen, Bregje D
AU  - Onwuteaka-Philipsen BD
FAU - Rurup, Mette L
AU  - Rurup ML
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20110706
PL  - United States
TA  - Qual Health Res
JT  - Qualitative health research
JID - 9202144
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/psychology
MH  - *Attitude to Death
MH  - Belgium
MH  - Communication
MH  - Cross-Cultural Comparison
MH  - Cultural Diversity
MH  - Emotions
MH  - Female
MH  - *Geriatric Assessment
MH  - Germany
MH  - Humans
MH  - *Interview, Psychological
MH  - Male
MH  - Middle Aged
MH  - Netherlands
MH  - Professional-Patient Relations
MH  - Qualitative Research
MH  - Terminal Care/*psychology
MH  - United Kingdom
EDAT- 2011/07/08 06:00
MHDA- 2012/02/10 06:00
CRDT- 2011/07/08 06:00
PHST- 2011/07/08 06:00 [entrez]
PHST- 2011/07/08 06:00 [pubmed]
PHST- 2012/02/10 06:00 [medline]
AID - 1049732311415286 [pii]
AID - 10.1177/1049732311415286 [doi]
PST - ppublish
SO  - Qual Health Res. 2011 Nov;21(11):1588-600. doi: 10.1177/1049732311415286. Epub
      2011 Jul 6.


PMID- 21734157
OWN - NLM
STAT- MEDLINE
DCOM- 20120227
LR  - 20220317
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 260
IP  - 3
DP  - 2011 Sep
TI  - Late stage complicated atheroma in low-grade stenotic carotid disease: MR imaging
      depiction--prevalence and risk factors.
PG  - 841-7
LID - 10.1148/radiol.11101652 [doi]
AB  - PURPOSE: To determine if complicated plaque can be found by using magnetic
      resonance (MR) imaging-depicted intraplaque hemorrhage (IPH), even among
      symptomatic patients with low-grade (</=50%) carotid stenosis. MATERIALS AND
      METHODS: The institutional ethics review board approved this retrospective study 
      and waived requirements for written informed consent. Symptomatic patients with
      bilateral 0%-50% carotid stenosis referred for carotid MR imaging were
      considered. Risk factors (age, sex, hypertension, diabetes, hyperlipidemia,
      myocardial infarction, atrial fibrillation, smoking, coronary artery disease, and
      cerebrovascular disease), medications (antihypertensive drugs, diabetes drugs,
      statins, and aspirin), and the brain side causing symptoms were recorded.
      MR-depicted IPH prevalence in the carotid arteries ipsilateral and contralateral 
      to the symptomatic side was compared by using the Fisher exact test.
      Multivariable regression was used to compare the MR-depicted IPH prevalence,
      while adjusting for risk factors and medications. RESULTS: A total of 217
      patients (434 carotid arteries) were included. MR-depicted IPH was found in 13%
      (31 of 233) of carotid arteries ipsilateral and 7% (14 of 201) of arteries
      contralateral to symptoms (P < .05). Male sex (P < .05) and increasing age (P <
      .05) were associated with MR-depicted IPH after controlling for risk factors and 
      medications. CONCLUSION: Complicated carotid atheroma can be found among
      symptomatic patients with low-grade (</=50%) stenosis, and this is associated
      with male sex and increasing age. MR-depicted IPH may be useful to stratify risk 
      for patients with low-grade carotid stenosis.
FAU - Cheung, Helen M C
AU  - Cheung HM
AD  - Department of Medical Imaging, Sunnybrook Health Sciences Centre, University of
      Toronto, 2075 Bayview Ave, Toronto, ON, Canada.
FAU - Moody, Alan R
AU  - Moody AR
FAU - Singh, Navneet
AU  - Singh N
FAU - Bitar, Richard
AU  - Bitar R
FAU - Zhan, James
AU  - Zhan J
FAU - Leung, General
AU  - Leung G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110706
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
CIN - Radiology. 2012 Mar;262(3):1045-6; author reply 1046-7. PMID: 22357908
MH  - Aged
MH  - Aged, 80 and over
MH  - Carotid Stenosis/*diagnosis/*epidemiology
MH  - Comorbidity
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Ontario/epidemiology
MH  - Plaque, Atherosclerotic/*diagnosis/*epidemiology
MH  - Prevalence
MH  - Risk Assessment
MH  - Risk Factors
MH  - Sex Distribution
EDAT- 2011/07/08 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/07/08 06:00
PHST- 2011/07/08 06:00 [entrez]
PHST- 2011/07/08 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - radiol.11101652 [pii]
AID - 10.1148/radiol.11101652 [doi]
PST - ppublish
SO  - Radiology. 2011 Sep;260(3):841-7. doi: 10.1148/radiol.11101652. Epub 2011 Jul 6.


PMID- 21733989
OWN - NLM
STAT- MEDLINE
DCOM- 20120829
LR  - 20220331
IS  - 1460-2237 (Electronic)
IS  - 0268-1080 (Linking)
VI  - 27 Suppl 2
DP  - 2012 May
TI  - National decision-making on adopting new vaccines: a systematic review.
PG  - ii62-76
LID - 10.1093/heapol/czr049 [doi]
AB  - In recent years numerous new vaccines have been developed, offering potential
      reductions in the morbidity and mortality caused by a range of diseases. This has
      led to increased interest in decision-making about the adoption of new vaccines
      into national immunization programmes. This paper aims to systematically review
      the literature on national decision-making around the adoption of new vaccines. A
      thematic framework was developed inductively through analysis of the vaccine
      adoption decision-making frameworks included in the review. This thematic
      framework was then applied to the remaining studies included in the review. In
      total, 85 articles were included in the review: 39 articles describing examples
      of vaccine adoption decision-making, 26 presenting vaccine decision-making
      frameworks, 21 empirical articles of decision-making relating to vaccine adoption
      and 19 theoretical essays. An analysis of vaccine adoption decision-making
      frameworks identified nine broad categories of criteria: the importance of the
      health problem; vaccine characteristics; immunization programme considerations;
      acceptability; accessibility, equity and ethics; financial/economic issues;
      impact; alternative interventions and the decision-making process. The quality of
      the empirical studies was varied. Although some of the issues included in the
      frameworks were similar to those considered in the studies, there were also some 
      notable differences. On the whole, the frameworks were more comprehensive than
      the studies, including a greater range of criteria. The existing literature
      provides a good foundation for further research into vaccine adoption
      decision-making. The current review, in pulling together what is already known
      and by identifying strengths, weaknesses and gaps in the existing evidence base, 
      aims to encourage a more focused and rigorous approach to the topic in future.
      This could help to identify the most appropriate ways to develop vaccine adoption
      decision-making, so as to improve decisions and, ultimately, health outcomes.
FAU - Burchett, H E D
AU  - Burchett HE
AD  - Department of Global Health and Development, London School of Hygiene and
      Tropical Medicine, 15-17 Tavistock Place, London WC1H 9SH, UK.
      Helen.Burchett@lshtm.ac.uk
FAU - Mounier-Jack, S
AU  - Mounier-Jack S
FAU - Griffiths, U K
AU  - Griffiths UK
FAU - Mills, A J
AU  - Mills AJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20110706
PL  - England
TA  - Health Policy Plan
JT  - Health policy and planning
JID - 8610614
RN  - 0 (Vaccines)
MH  - Decision Making, Organizational
MH  - Health Priorities
MH  - Humans
MH  - Immunization Programs/*organization & administration
MH  - *Policy Making
MH  - Vaccines/*therapeutic use
EDAT- 2011/07/08 06:00
MHDA- 2012/08/30 06:00
CRDT- 2011/07/08 06:00
PHST- 2011/07/08 06:00 [entrez]
PHST- 2011/07/08 06:00 [pubmed]
PHST- 2012/08/30 06:00 [medline]
AID - czr049 [pii]
AID - 10.1093/heapol/czr049 [doi]
PST - ppublish
SO  - Health Policy Plan. 2012 May;27 Suppl 2:ii62-76. doi: 10.1093/heapol/czr049. Epub
      2011 Jul 6.


PMID- 21733960
OWN - NLM
STAT- MEDLINE
DCOM- 20120319
LR  - 20111130
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 6
DP  - 2011 Nov
TI  - Empirical and normative ethics: a synthesis relating to the care of older
      patients.
PG  - 814-24
LID - 10.1177/0969733011405875 [doi]
AB  - The aim of this study was to synthesize the concepts from empirical studies and
      analyze, compare and interrelate them with normative ethics. The International
      Council of Nurses (ICN) and the Health and Medical Service Act are normative
      ethics. Five concepts were used in the analysis; three from the grounded theory
      studies and two from the theoretical framework on normative ethics. A
      simultaneous concept analysis resulted in five outcomes: interconnectedness,
      interdependence, corroboratedness, completeness and good care are all related to 
      the empirical perspective of the nurse's interaction with the older patient, and 
      the normative perspective, i.e. that found in ICN code and SFS law. Empirical
      ethics and normative ethics are intertwined according to the findings of this
      study. Normative ethics influence the nurse's practical performance and could be 
      supporting documents for nurses as professionals.
FAU - Jonasson, Lise-Lotte
AU  - Jonasson LL
AD  - Department of Nursing Science, School of Health Sciences, University of
      Jonkoping, Sweden. Lise-Lotte.Jonasson@hhj.hj.se
FAU - Liss, Per-Erik
AU  - Liss PE
FAU - Westerlind, Bjorn
AU  - Westerlind B
FAU - Bertero, Carina
AU  - Bertero C
LA  - eng
PT  - Journal Article
DEP - 20110706
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Aged
MH  - *Empirical Research
MH  - *Ethical Theory
MH  - Geriatric Nursing/*ethics
MH  - Humans
MH  - International Council of Nurses
MH  - Nurse-Patient Relations/*ethics
MH  - Nursing Methodology Research
EDAT- 2011/07/08 06:00
MHDA- 2012/03/20 06:00
CRDT- 2011/07/08 06:00
PHST- 2011/07/08 06:00 [entrez]
PHST- 2011/07/08 06:00 [pubmed]
PHST- 2012/03/20 06:00 [medline]
AID - 0969733011405875 [pii]
AID - 10.1177/0969733011405875 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Nov;18(6):814-24. doi: 10.1177/0969733011405875. Epub 2011 Jul 
      6.


PMID- 21733897
OWN - NLM
STAT- MEDLINE
DCOM- 20120419
LR  - 20211020
IS  - 1471-2954 (Electronic)
IS  - 0962-8452 (Linking)
VI  - 279
IP  - 1728
DP  - 2012 Feb 7
TI  - Bad to the bone: facial structure predicts unethical behaviour.
PG  - 571-6
LID - 10.1098/rspb.2011.1193 [doi]
AB  - Researchers spanning many scientific domains, including primatology, evolutionary
      biology and psychology, have sought to establish an evolutionary basis for
      morality. While researchers have identified social and cognitive adaptations that
      support ethical behaviour, a consensus has emerged that genetically determined
      physical traits are not reliable signals of unethical intentions or actions.
      Challenging this view, we show that genetically determined physical traits can
      serve as reliable predictors of unethical behaviour if they are also associated
      with positive signals in intersex and intrasex selection. Specifically, we
      identify a key physical attribute, the facial width-to-height ratio, which
      predicts unethical behaviour in men. Across two studies, we demonstrate that men 
      with wider faces (relative to facial height) are more likely to explicitly
      deceive their counterparts in a negotiation, and are more willing to cheat in
      order to increase their financial gain. Importantly, we provide evidence that the
      link between facial metrics and unethical behaviour is mediated by a
      psychological sense of power. Our results demonstrate that static physical
      attributes can indeed serve as reliable cues of immoral action, and provide
      additional support for the view that evolutionary forces shape ethical judgement 
      and behaviour.
FAU - Haselhuhn, Michael P
AU  - Haselhuhn MP
AD  - University of Wisconsin-Milwaukee, 3202 N. Maryland Avenue, Milwaukee, WI 53211, 
      USA. haselhuh@uwm.edu
FAU - Wong, Elaine M
AU  - Wong EM
LA  - eng
PT  - Journal Article
DEP - 20110706
PL  - England
TA  - Proc Biol Sci
JT  - Proceedings. Biological sciences
JID - 101245157
SB  - IM
MH  - Adult
MH  - *Aggression
MH  - *Biological Evolution
MH  - Cues
MH  - *Deception
MH  - Face/*anatomy & histology
MH  - Female
MH  - Humans
MH  - Male
MH  - Power, Psychological
MH  - Sex Distribution
MH  - United States
MH  - Young Adult
PMC - PMC3234568
EDAT- 2011/07/08 06:00
MHDA- 2012/04/20 06:00
CRDT- 2011/07/08 06:00
PHST- 2011/07/08 06:00 [entrez]
PHST- 2011/07/08 06:00 [pubmed]
PHST- 2012/04/20 06:00 [medline]
AID - rspb.2011.1193 [pii]
AID - 10.1098/rspb.2011.1193 [doi]
PST - ppublish
SO  - Proc Biol Sci. 2012 Feb 7;279(1728):571-6. doi: 10.1098/rspb.2011.1193. Epub 2011
      Jul 6.


PMID- 21733178
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20220410
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 12
DP  - 2011 Jul 6
TI  - Early postoperative cognitive dysfunction and postoperative delirium after
      anaesthesia with various hypnotics: study protocol for a randomised controlled
      trial--the PINOCCHIO trial.
PG  - 170
LID - 10.1186/1745-6215-12-170 [doi]
AB  - BACKGROUND: Postoperative delirium can result in increased postoperative
      morbidity and mortality, major demand for postoperative care and higher hospital 
      costs. Hypnotics serve to induce and maintain anaesthesia and to abolish
      patients' consciousness. Their persisting clinical action can delay postoperative
      cognitive recovery and favour postoperative delirium. Some evidence suggests that
      these unwanted effects vary according to each hypnotic's specific pharmacodynamic
      and pharmacokinetic characteristics and its interaction with the individual
      patient.We designed this study to evaluate postoperative delirium rate after
      general anaesthesia with various hypnotics in patients undergoing surgical
      procedures other than cardiac or brain surgery. We also aimed to test whether
      delayed postoperative cognitive recovery increases the risk of postoperative
      delirium. METHODS/DESIGN: After local ethics committee approval, enrolled
      patients will be randomly assigned to one of three treatment groups. In all
      patients anaesthesia will be induced with propofol and fentanyl, and maintained
      with the anaesthetics desflurane, or sevoflurane, or propofol and the analgesic
      opioid fentanyl.The onset of postoperative delirium will be monitored with the
      Nursing Delirium Scale every three hours up to 72 hours post anaesthesia.
      Cognitive function will be evaluated with two cognitive test batteries (the Short
      Memory Orientation Memory Concentration Test and the Rancho Los Amigos Scale)
      preoperatively, at baseline, and postoperatively at 20, 40 and 60 min after
      extubation.Statistical analysis will investigate differences in the hypnotics
      used to maintain anaesthesia and the odds ratios for postoperative delirium, the 
      relation of early postoperative cognitive recovery and postoperative delirium
      rate. A subgroup analysis will be used to categorize patients according to
      demographic variables relevant to the risk of postoperative delirium (age, sex,
      body weight) and to the preoperative score index for delirium. DISCUSSION: The
      results of this comparative anaesthesiological trial should whether each the
      three hypnotics tested is related to a significantly different postoperative
      delirium rate. This information could ultimately allow us to select the most
      appropriate hypnotic to maintain anaesthesia for specific subgroups of patients
      and especially for those at high risk of postoperative delirium. REGISTERED AT
      TRIAL.GOV NUMBER: ClinicalTrials.gov: NCT00507195.
FAU - Bilotta, Federico
AU  - Bilotta F
AD  - Department of Anaesthesiology, Critical Care and Pain Medicine, Sapienza
      University of Rome, Policlinico Umberto I, Rome, Italy. bilotta@tiscali.it
FAU - Doronzio, Andrea
AU  - Doronzio A
FAU - Stazi, Elisabetta
AU  - Stazi E
FAU - Titi, Luca
AU  - Titi L
FAU - Zeppa, Ivan Orlando
AU  - Zeppa IO
FAU - Cianchi, Antonella
AU  - Cianchi A
FAU - Rosa, Giovanni
AU  - Rosa G
FAU - Paoloni, Francesca Paola
AU  - Paoloni FP
FAU - Bergese, Sergio
AU  - Bergese S
FAU - Asouhidou, Irene
AU  - Asouhidou I
FAU - Ioannou, Polimnia
AU  - Ioannou P
FAU - Abramowicz, Apolonia Elisabeth
AU  - Abramowicz AE
FAU - Spinelli, Allison
AU  - Spinelli A
FAU - Delphin, Ellise
AU  - Delphin E
FAU - Ayrian, Eugenia
AU  - Ayrian E
FAU - Zelman, Vladimir
AU  - Zelman V
FAU - Lumb, Philip
AU  - Lumb P
LA  - eng
SI  - ClinicalTrials.gov/NCT00507195
PT  - Clinical Trial, Phase II
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
DEP - 20110706
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
RN  - 0 (Anesthetics, Inhalation)
RN  - 0 (Anesthetics, Intravenous)
RN  - 0 (Hypnotics and Sedatives)
RN  - 0 (Methyl Ethers)
RN  - 38LVP0K73A (Sevoflurane)
RN  - CRS35BZ94Q (Desflurane)
RN  - CYS9AKD70P (Isoflurane)
RN  - UF599785JZ (Fentanyl)
RN  - YI7VU623SF (Propofol)
SB  - IM
MH  - Anesthesia, General/*adverse effects/methods
MH  - Anesthetics, Inhalation/administration & dosage/*adverse effects
MH  - Anesthetics, Intravenous/administration & dosage/*adverse effects
MH  - Cognition/*drug effects
MH  - Cognition Disorders/*chemically induced/diagnosis/psychology
MH  - Delirium/*chemically induced/diagnosis/psychology
MH  - Desflurane
MH  - Double-Blind Method
MH  - Fentanyl/adverse effects
MH  - Humans
MH  - Hypnotics and Sedatives/administration & dosage/*adverse effects
MH  - Isoflurane/adverse effects/analogs & derivatives
MH  - Italy
MH  - Methyl Ethers/adverse effects
MH  - Neuropsychological Tests
MH  - Odds Ratio
MH  - Propofol/adverse effects
MH  - Prospective Studies
MH  - *Research Design
MH  - Risk Assessment
MH  - Risk Factors
MH  - Sevoflurane
MH  - Time Factors
MH  - Treatment Outcome
PMC - PMC3155116
EDAT- 2011/07/08 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/07/08 06:00
PHST- 2010/04/30 00:00 [received]
PHST- 2011/07/06 00:00 [accepted]
PHST- 2011/07/08 06:00 [entrez]
PHST- 2011/07/08 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - 1745-6215-12-170 [pii]
AID - 10.1186/1745-6215-12-170 [doi]
PST - epublish
SO  - Trials. 2011 Jul 6;12:170. doi: 10.1186/1745-6215-12-170.


PMID- 21733017
OWN - NLM
STAT- MEDLINE
DCOM- 20120507
LR  - 20220317
IS  - 1365-2702 (Electronic)
IS  - 0962-1067 (Linking)
VI  - 21
IP  - 3-4
DP  - 2012 Feb
TI  - Pressure ulcer prevalence and prevention practices in care of the older person in
      the Republic of Ireland.
PG  - 362-71
LID - 10.1111/j.1365-2702.2011.03749.x [doi]
AB  - AIMS AND OBJECTIVES: The aim of this study was to establish pressure ulcer
      prevalence and prevention in the long-term care setting. BACKGROUND: There is no 
      information on pressure ulcers prevalence in care of the older person in Ireland;
      therefore, a prevalence study was undertaken to investigate key aspects related
      to current practices in pressure ulcer prevention. DESIGN: A cross-sectional
      survey design was employed. METHOD: Ethical approval was received. Participants
      included 1100 older individuals residing in 12 long-term care settings. Data were
      collected using the Braden scale, the European Pressure Ulcer Advisory Panel
      minimum data set and pressure ulcer grading system. RESULTS: All participants
      were Irish and white, 70% were women, and 75% were aged 80 years or older.
      Prevalence was 9%, with 28% of pressure ulcers grade 1, 33% grade 2, 15% grade 3 
      and 24% grade 4, mainly located on the sacrum (58%) and the heel (25%).
      Seventy-seven per cent scored Braden low risk or not at risk; however, 53% were
      completely immobile/very limited mobility and 58% were chair/bedfast. There was a
      significant association between activity and mobility and pressure ulcer
      development (chi(2) = 45.50, p < 0.001 and chi(2) = 46.91, p = 0.0001,
      respectively). Fifty per cent had a pressure redistribution device in bed, and
      48% had one in use on the chair; however, 9% had a repositioning regime planned
      for when in bed and 5% planned for when seated in the chair. CONCLUSIONS: This
      paper reports on the first ever pressure ulcer prevalence survey conducted in
      long-term care in Ireland, and results provide significant insights into
      decision-making and use of resources in the prevention of pressure ulcers.
      RELEVANCE TO CLINICAL PRACTICE: Pressure ulcers are common, costly and impact
      negatively on individuals. Current practices in prevention show several areas for
      improvement, namely, risk assessment, care planning and documentation.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Moore, Zena
AU  - Moore Z
AD  - Wound Healing and Tissue Repair and Research Methodology, Faculty of Nursing and 
      Midwifery, Royal College of Surgeons in Ireland, Dublin, Ireland. zmoore@rcsi.ie
FAU - Cowman, Seamus
AU  - Cowman S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110707
PL  - England
TA  - J Clin Nurs
JT  - Journal of clinical nursing
JID - 9207302
CIN - J Clin Nurs. 2012 Apr;21(7-8):1191-2. PMID: 22409784
MH  - Aged
MH  - Aged, 80 and over
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Ireland/epidemiology
MH  - Male
MH  - Pressure Ulcer/*epidemiology
MH  - Prevalence
MH  - Risk Factors
EDAT- 2011/07/08 06:00
MHDA- 2012/05/09 06:00
CRDT- 2011/07/08 06:00
PHST- 2011/07/08 06:00 [entrez]
PHST- 2011/07/08 06:00 [pubmed]
PHST- 2012/05/09 06:00 [medline]
AID - 10.1111/j.1365-2702.2011.03749.x [doi]
PST - ppublish
SO  - J Clin Nurs. 2012 Feb;21(3-4):362-71. doi: 10.1111/j.1365-2702.2011.03749.x. Epub
      2011 Jul 7.


PMID- 21732978
OWN - NLM
STAT- MEDLINE
DCOM- 20120302
LR  - 20111206
IS  - 1651-2227 (Electronic)
IS  - 0803-5253 (Linking)
VI  - 101
IP  - 1
DP  - 2012 Jan
TI  - Impact of the new european paediatric regulatory framework on ethics committees: 
      overview and perspectives.
PG  - e27-32
LID - 10.1111/j.1651-2227.2011.02401.x [doi]
AB  - AIM: To evaluate the impact of the new European paediatric regulatory framework
      on the activities of Ethics Committees operating in Europe and to assess their
      involvement and interest in paediatric research. METHODS: Task-force in Europe
      for Drug Development for the Young Network of Excellence and Relating
      Expectations and Needs to the Participation and Empowerment of Children in
      Clinical Trials project set up an inventory of Ethics Committees existing in
      Europe and conducted a survey on their approach to paediatric trials. RESULTS:
      Ethics Committees operating in 22 European Countries participated in this survey.
      Results showed a high lack of knowledge, understanding and awareness of the
      current European paediatric regulatory framework and a lack of involvement of
      Ethics Committees in paediatric research, especially in terms of training and
      education, demonstrated also by the decreasing number of Ethics Committees
      answering exhaustively to the whole questionnaire. The majority of participating 
      Ethics Committees expressed interest in future initiatives related to paediatric 
      research. CONCLUSIONS: Despite a limited knowledge and understanding of the
      current paediatric regulatory framework, a significant number of Ethics
      Committees operating in Europe show interest in initiatives related to paediatric
      research. Networking may be an essential tool to be used to enhance Ethics
      Committees role in supporting paediatric research. Any initiative should be
      undertaken at European level in collaboration with European Union Institutions.
CI  - (c) 2011 The Author(s)/Acta Paediatrica (c) 2011 Foundation Acta Paediatrica.
FAU - Altavilla, A
AU  - Altavilla A
AD  - Universite de la Mediterranee - Espace Ethique Mediterraneen, Marseille, France.
FAU - Manfredi, C
AU  - Manfredi C
FAU - Baiardi, P
AU  - Baiardi P
FAU - Dehlinger-Kremer, M
AU  - Dehlinger-Kremer M
FAU - Galletti, P
AU  - Galletti P
FAU - Pozuelo, A Alemany
AU  - Pozuelo AA
FAU - Chaplin, J
AU  - Chaplin J
FAU - Ceci, A
AU  - Ceci A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110723
PL  - Norway
TA  - Acta Paediatr
JT  - Acta paediatrica (Oslo, Norway : 1992)
JID - 9205968
SB  - IM
MH  - Bioethical Issues
MH  - Child
MH  - Clinical Trials as Topic/*ethics
MH  - *Ethics Committees
MH  - European Union
MH  - Humans
MH  - Pediatrics/*legislation & jurisprudence
EDAT- 2011/07/08 06:00
MHDA- 2012/03/03 06:00
CRDT- 2011/07/08 06:00
PHST- 2011/07/08 06:00 [entrez]
PHST- 2011/07/08 06:00 [pubmed]
PHST- 2012/03/03 06:00 [medline]
AID - 10.1111/j.1651-2227.2011.02401.x [doi]
PST - ppublish
SO  - Acta Paediatr. 2012 Jan;101(1):e27-32. doi: 10.1111/j.1651-2227.2011.02401.x.
      Epub 2011 Jul 23.


PMID- 21732972
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20220318
IS  - 1525-1446 (Electronic)
IS  - 0737-1209 (Linking)
VI  - 28
IP  - 2
DP  - 2011 Mar-Apr
TI  - The skills gap in nursing management in the South African public health sector.
PG  - 176-85
LID - 10.1111/j.1525-1446.2010.00910.x [doi]
AB  - OBJECTIVES: Nurse managers are central to health delivery in South Africa.
      However, there is a paucity of research that analyzes their competence to
      successfully discharge their managerial role. To identify the competencies
      perceived to be important for effective nursing management in the South African
      public sector and the managers' self-assessed proficiency in these. DESIGN AND
      SAMPLE: A cross-sectional survey using a self-administered questionnaire. 215
      senior nursing managers at South African public sector hospitals. MEASURES:
      Respondents rated the level of importance that 51 proposed competencies had in
      their job and indicated their proficiency in each. RESULTS: Public sector
      managers ranked controlling as the most important competency, followed by
      leading, organizing, and self-management. Health/clinical skills, planning, and
      legal/ethical competencies were ranked as being relatively less important. They
      assessed themselves as being most competent in self-management, followed by
      planning, controlling, leading, and specific health skills. The competency gap
      was the largest for legal/ethical issues, organizing, and controlling. The
      competency gap for planning and self-management was relatively smaller.
      CONCLUSIONS: This research confirms that there is a lack of management capacity
      within the public health sector and also identifies the areas in which the lack
      of knowledge or skills is most significant.
CI  - (c) 2011 Wiley Periodicals, Inc.
FAU - Pillay, Rubin
AU  - Pillay R
AD  - Director of Interdisciplinary Entrepreneurship Academy, School of
      Entrepreneurship, Spears School of Business, Oklahoma State University,
      Stillwater, OK 74078, USA. rubin.pillay@okstate.edu
LA  - eng
PT  - Journal Article
DEP - 20110120
PL  - United States
TA  - Public Health Nurs
JT  - Public health nursing (Boston, Mass.)
JID - 8501498
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Chi-Square Distribution
MH  - *Clinical Competence
MH  - Cross-Sectional Studies
MH  - Delivery of Health Care/organization & administration
MH  - Female
MH  - Health Care Surveys
MH  - Health Knowledge, Attitudes, Practice
MH  - Hospitals, Public/*organization & administration/standards
MH  - Humans
MH  - Leadership
MH  - Male
MH  - Middle Aged
MH  - Nurse Administrators/*organization & administration/standards
MH  - Nursing, Supervisory/*organization & administration/standards
MH  - *Public Health
MH  - Public Health Nursing/*organization & administration/standards
MH  - Public Sector
MH  - Quality of Health Care/standards
MH  - Self-Assessment
MH  - South Africa
MH  - Surveys and Questionnaires
EDAT- 2011/07/08 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/07/08 06:00
PHST- 2011/07/08 06:00 [entrez]
PHST- 2011/07/08 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 10.1111/j.1525-1446.2010.00910.x [doi]
PST - ppublish
SO  - Public Health Nurs. 2011 Mar-Apr;28(2):176-85. doi:
      10.1111/j.1525-1446.2010.00910.x. Epub 2011 Jan 20.


PMID- 21732971
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20110707
IS  - 1525-1446 (Electronic)
IS  - 0737-1209 (Linking)
VI  - 28
IP  - 2
DP  - 2011 Mar-Apr
TI  - Philosophical and ethical perspectives on cardiovascular disease risk in low-wage
      workers.
PG  - 168-75
LID - 10.1111/j.1525-1446.2010.00922.x [doi]
AB  - One of the overriding goals of Healthy People 2010 is to reduce the health
      disparities observed among Americans. Because workers in small businesses tend to
      have little or no access to health screening or preventive health education
      programs, they may be unaware of their unique risk factors and are thus more at
      risk of cardiovascular disease (CVD). Furthermore, occupational health nurses are
      more likely to be available in health programs to employees in large rather than 
      small businesses. The purpose of this paper is to illustrate how nursing values
      and philosophy might influence public health nurses' thinking about nursing
      science and ethical issues relating to the risk of CVD among low-wage workers.
      The following questions will guide the exploration of health disparities among
      low-wage workers: (a) What are the health disparities observed among low-wage
      workers with CVD risk? (b) What are the philosophical and ethical perspectives on
      the issues presented? (c) Based on these findings, how should limited resources
      be allocated? and (d) How does this affect nursing? These approaches will provide
      the foundation for developing a culturally sensitive ethical and philosophical
      perspective to prevent CVD and promote cardiovascular health among low-wage
      workers.
CI  - (c) 2011 Wiley Periodicals, Inc.
FAU - Hwang, Won Ju
AU  - Hwang WJ
AD  - Department of Community Health System, School of Nursing, University of
      California-San Francisco, CA 94131, USA. wonju.hwang@ucsf.edu
LA  - eng
PT  - Journal Article
DEP - 20110120
PL  - United States
TA  - Public Health Nurs
JT  - Public health nursing (Boston, Mass.)
JID - 8501498
SB  - IM
MH  - Cardiovascular Diseases/economics/*epidemiology/nursing
MH  - Empiricism
MH  - Ethical Theory
MH  - *Ethics, Medical
MH  - Feminism
MH  - Health Knowledge, Attitudes, Practice
MH  - Health Promotion/methods
MH  - Health Resources
MH  - *Health Status Disparities
MH  - Humans
MH  - Personal Autonomy
MH  - *Philosophy
MH  - Prejudice
MH  - Resource Allocation
MH  - Risk Assessment/methods
MH  - Risk Factors
MH  - Social Justice
MH  - Social Marketing
MH  - Socioeconomic Factors
MH  - United States/epidemiology
MH  - Workplace
EDAT- 2011/07/08 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/07/08 06:00
PHST- 2011/07/08 06:00 [entrez]
PHST- 2011/07/08 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 10.1111/j.1525-1446.2010.00922.x [doi]
PST - ppublish
SO  - Public Health Nurs. 2011 Mar-Apr;28(2):168-75. doi:
      10.1111/j.1525-1446.2010.00922.x. Epub 2011 Jan 20.


PMID- 21732965
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20110707
IS  - 1525-1446 (Electronic)
IS  - 0737-1209 (Linking)
VI  - 28
IP  - 2
DP  - 2011 Mar-Apr
TI  - History, ethics, and the truth.
PG  - 105-6
LID - 10.1111/j.1525-1446.2011.00942.x [doi]
FAU - Abrams, Sarah E
AU  - Abrams SE
LA  - eng
PT  - Editorial
PT  - Historical Article
PL  - United States
TA  - Public Health Nurs
JT  - Public health nursing (Boston, Mass.)
JID - 8501498
SB  - IM
MH  - Ethics/*history
MH  - History, 20th Century
MH  - Humans
MH  - *Prejudice
MH  - *Truth Disclosure
MH  - United States
MH  - United States Public Health Service
EDAT- 2011/07/08 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/07/08 06:00
PHST- 2011/07/08 06:00 [entrez]
PHST- 2011/07/08 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 10.1111/j.1525-1446.2011.00942.x [doi]
PST - ppublish
SO  - Public Health Nurs. 2011 Mar-Apr;28(2):105-6. doi:
      10.1111/j.1525-1446.2011.00942.x.


PMID- 21732923
OWN - NLM
STAT- MEDLINE
DCOM- 20110908
LR  - 20211020
IS  - 1532-5415 (Electronic)
IS  - 0002-8614 (Linking)
VI  - 59
IP  - 7
DP  - 2011 Jul
TI  - Timing of do-not-resuscitate orders for hospitalized older adults who require a
      surrogate decision-maker.
PG  - 1326-31
LID - 10.1111/j.1532-5415.2011.03480.x [doi]
AB  - OBJECTIVES: To examine the frequency of surrogate decisions for in-hospital
      do-not-resuscitate (DNR) orders and the timing of DNR order entry for surrogate
      decisions. DESIGN: Retrospective cohort study. SETTING: Large, urban, public
      hospital. PARTICIPANTS: Hospitalized adults aged 65 and older over a 3-year
      period (1/1/2004-12/31/2006) with a DNR order during their hospital stay.
      MEASUREMENTS: Electronic chart review provided data on frequency of surrogate
      decisions, patient demographic and clinical characteristics, and timing of DNR
      orders. RESULTS: Of 668 patients, the ordering physician indicated that the DNR
      decision was made with the patient in 191 cases (28.9%), the surrogate in 389
      (58.2%), and both in 88 (13.2%). Patients who required a surrogate were more
      likely to be in the intensive care unit (62.2% vs 39.8%, P<.001) but did not
      differ according to demographic characteristics. By hospital Day 3, 77.6% of
      patient decisions, 61.9% of surrogate decisions, and 58.0% of shared decisions
      had been made. In multivariable models, the number of days from admission to DNR 
      order was higher for surrogate (odds ratio (OR)=1.97, P<.001) and shared
      decisions (OR=1.48, P=.009) than for patient decisions. The adjusted hazard ratio
      for hospital death was higher for patients with surrogate than patient decisions 
      (2.61, 95% confidence interval (CI)=1.56-4.36). Patients whose DNR orders were
      written on Day 6 or later were twice as likely to die in the hospital (OR=2.20,
      95% CI=1.45-3.36) than patients with earlier DNR orders. CONCLUSION: For patients
      who have a DNR order entered during their hospital stay, order entry occurs later
      when a surrogate is involved. Surrogate decision-making may take longer because
      of the greater ethical, emotional, or communication complexity of making
      decisions with surrogates than with patients.
CI  - (c) 2011, Copyright the Authors. Journal compilation (c) 2011, The American
      Geriatrics Society.
FAU - Torke, Alexia M
AU  - Torke AM
AD  - Center for Aging Research, Regenstrief Institute, Indianapolis, IN 46202, USA.
      atorke@iupui.edu
FAU - Sachs, Greg A
AU  - Sachs GA
FAU - Helft, Paul R
AU  - Helft PR
FAU - Petronio, Sandra
AU  - Petronio S
FAU - Purnell, Christianna
AU  - Purnell C
FAU - Hui, Siu
AU  - Hui S
FAU - Callahan, Christopher M
AU  - Callahan CM
LA  - eng
GR  - P30 AG024967/AG/NIA NIH HHS/United States
GR  - K23 AG031323/AG/NIA NIH HHS/United States
GR  - K23AG031323/AG/NIA NIH HHS/United States
GR  - P30AG024967/AG/NIA NIH HHS/United States
GR  - K23 AG031323-03/AG/NIA NIH HHS/United States
GR  - K24 4682309/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110707
PL  - United States
TA  - J Am Geriatr Soc
JT  - Journal of the American Geriatrics Society
JID - 7503062
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cohort Studies
MH  - *Decision Making
MH  - Female
MH  - *Hospitalization
MH  - Humans
MH  - Legal Guardians
MH  - Male
MH  - *Resuscitation Orders
MH  - Retrospective Studies
MH  - Time Factors
PMC - PMC3167071
MID - NIHMS319237
EDAT- 2011/07/08 06:00
MHDA- 2011/09/09 06:00
CRDT- 2011/07/08 06:00
PHST- 2011/07/08 06:00 [entrez]
PHST- 2011/07/08 06:00 [pubmed]
PHST- 2011/09/09 06:00 [medline]
AID - 10.1111/j.1532-5415.2011.03480.x [doi]
PST - ppublish
SO  - J Am Geriatr Soc. 2011 Jul;59(7):1326-31. doi: 10.1111/j.1532-5415.2011.03480.x. 
      Epub 2011 Jul 7.


PMID- 21732820
OWN - NLM
STAT- MEDLINE
DCOM- 20120222
LR  - 20161125
IS  - 1557-8100 (Electronic)
IS  - 1536-2310 (Linking)
VI  - 15
IP  - 9
DP  - 2011 Sep
TI  - Publics and vaccinomics: beyond public understanding of science.
PG  - 607-14
LID - 10.1089/omi.2010.0139 [doi]
AB  - Vaccines have been among the most effective tools for addressing global public
      health challenges. With the advent of genomics, novel approaches for vaccine
      discovery are opening up new opportunities for vaccine development and
      applications, particularly with the expectation of personalized vaccines and the 
      possibility of addressing a broader range of infectious diseases. In this
      context, it is useful to reflect on the social contexts of vaccine development as
      these have been influenced by social, ethical, political challenges. This article
      discusses the historical context of vaccine controversies and factors that help
      explain public acceptance and resistance, illustrating that these challenges go
      well beyond simple public misunderstandings. The broader vaccine challenges
      evident along the innovation trajectory, from development to commercialization
      and implementation include problems in research and development, organizational
      issues, and legal and regulatory challenges that may collectively contribute to
      public resistance or confidence. The recent history of genomics provides further 
      lessons that the developing field of vaccinomics can learn from.
FAU - Einsiedel, Edna F
AU  - Einsiedel EF
AD  - Department of Communication and Culture, University of Calgary, Calgary, Alberta,
      Canada. einsiede@ucalgary.ca
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110706
PL  - United States
TA  - OMICS
JT  - Omics : a journal of integrative biology
JID - 101131135
RN  - 0 (Vaccines)
SB  - IM
MH  - Community Participation
MH  - Genomics
MH  - Humans
MH  - Information Dissemination
MH  - Mass Vaccination/ethics/legislation & jurisprudence/*organization &
      administration/trends
MH  - *Public Opinion
MH  - *Vaccines
EDAT- 2011/07/08 06:00
MHDA- 2012/02/23 06:00
CRDT- 2011/07/08 06:00
PHST- 2011/07/08 06:00 [entrez]
PHST- 2011/07/08 06:00 [pubmed]
PHST- 2012/02/23 06:00 [medline]
AID - 10.1089/omi.2010.0139 [doi]
PST - ppublish
SO  - OMICS. 2011 Sep;15(9):607-14. doi: 10.1089/omi.2010.0139. Epub 2011 Jul 6.


PMID- 21703567
OWN - NLM
STAT- MEDLINE
DCOM- 20111215
LR  - 20110627
IS  - 1934-1563 (Electronic)
IS  - 1934-1482 (Linking)
VI  - 3
IP  - 6 Suppl 1
DP  - 2011 Jun
TI  - Stem cells for central nervous system repair and rehabilitation.
PG  - S117-22
LID - 10.1016/j.pmrj.2011.02.011 [doi]
AB  - The central nervous system (CNS) has limited capacity for self-repair. Current
      treatments are often incapable of reversing the debilitating effects of CNS
      diseases that result in permanent and/or progressive physical and cognitive
      impairments. One promising repair strategy is transplantation of stem cells,
      which can potentially replace lost neurons and/or glia or promote repair through 
      secretion of trophic factors. Various types of stem cells exist, each with their 
      own advantages and disadvantages. Although no consensus exists regarding the
      optimal cell type to use, moderate functional improvements have been shown in
      animal models of CNS diseases using different types of stem cells. However, the
      precise mechanism of action behind their beneficial effects remains unknown. In
      addition, many barriers to clinical use still need to be resolved before
      transplantation of stem cells can be used as effective biologics. These barriers 
      include--depending on the stem cell type--possible tumor formation, difficulty
      with harvest, limited in vivo differentiation and integration, and ethical issues
      regarding use.
CI  - Copyright (c) 2011 American Academy of Physical Medicine and Rehabilitation.
      Published by Elsevier Inc. All rights reserved.
FAU - Ritfeld, Gaby J
AU  - Ritfeld GJ
AD  - Department of Physical Medicine & Rehabilitation, University of Pittsburgh School
      of Medicine, Pittsburgh, PA 15213, USA.
FAU - Roos, Raymund A C
AU  - Roos RA
FAU - Oudega, Martin
AU  - Oudega M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - PM R
JT  - PM & R : the journal of injury, function, and rehabilitation
JID - 101491319
SB  - IM
MH  - Central Nervous System/*physiology
MH  - Central Nervous System Diseases/*rehabilitation
MH  - Humans
MH  - Recovery of Function/*physiology
MH  - Stem Cell Transplantation/*methods
MH  - Stem Cells/*cytology
EDAT- 2011/07/08 06:00
MHDA- 2011/12/16 06:00
CRDT- 2011/06/28 06:00
PHST- 2010/09/17 00:00 [received]
PHST- 2011/02/11 00:00 [accepted]
PHST- 2011/06/28 06:00 [entrez]
PHST- 2011/07/08 06:00 [pubmed]
PHST- 2011/12/16 06:00 [medline]
AID - S1934-1482(11)00103-1 [pii]
AID - 10.1016/j.pmrj.2011.02.011 [doi]
PST - ppublish
SO  - PM R. 2011 Jun;3(6 Suppl 1):S117-22. doi: 10.1016/j.pmrj.2011.02.011.


PMID- 21731994
OWN - NLM
STAT- MEDLINE
DCOM- 20120105
LR  - 20191210
IS  - 0037-5675 (Print)
IS  - 0037-5675 (Linking)
VI  - 52
IP  - 6
DP  - 2011 Jun
TI  - Attitudes of rehabilitation medicine doctors toward medical ethics in Malaysia.
PG  - 421-7
AB  - INTRODUCTION: Medical ethics issues encountered in rehabilitation medicine differ
      from those in an acute care setting due to the complex relationships among the
      parties involved in rehabilitative care. The study examined the attitudes of
      Malaysian rehabilitation doctors toward medical ethics issues commonly
      encountered during patient care. METHODS: We surveyed 74 rehabilitation
      physicians and residents in Malaysia using a self-administered descriptive
      questionnaire. The questions covered medical ethics issues on allocation of
      resources, patient confidentiality, discharge planning, goal-setting,
      reimbursement documentation, decision-making capacity and withdrawal of life
      support. RESULTS: The overall response rate was 69 percent. More than 80 percent 
      of respondents would disclose confidential information to their team members if
      it would affect the rehabilitation process. More than two-thirds of respondents
      would not allocate scarce rehabilitation resources if the functional outcome is
      marginally positive. Issues involving patients' autonomy in decision-making, both
      in life-threatening and non-life-threatening situations, showed mix responses.
      The least common response was on the issue of discharge planning, where 51
      percent of respondents would send a patient back to a nursing home with
      suboptimal care if there were no other alternatives. CONCLUSION: The attitude of 
      Malaysian rehabilitation doctors toward ethical issues is reflective of the level
      of maturity of rehabilitation medicine in Malaysia. Issues on allocation of
      resources, discharge planning and decision-making capacity are significantly
      influenced by limited rehabilitation facilities in parts of the country. The lack
      of influence from external factors, such as a developed health insurance system, 
      contributes to the difference in attitude between rehabilitation doctors in
      Malaysia and those in developed countries.
FAU - Mazlina, M
AU  - Mazlina M
AD  - Department of Rehabilitation Medicine, 2nd Floor, Block R, Faculty of Medicine,
      University of Malaya, Kuala Lumpur 50603, Malaysia. drmazlina@gmail.com
FAU - Julia, P E
AU  - Julia PE
LA  - eng
PT  - Journal Article
PL  - Singapore
TA  - Singapore Med J
JT  - Singapore medical journal
JID - 0404516
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Confidentiality
MH  - Decision Making
MH  - *Ethics, Medical
MH  - Female
MH  - Humans
MH  - Malaysia
MH  - Male
MH  - Middle Aged
MH  - Outcome Assessment, Health Care
MH  - Patient Discharge
MH  - Physicians/*psychology
MH  - *Practice Patterns, Physicians'
MH  - Rehabilitation/*ethics/*methods
MH  - Surveys and Questionnaires
EDAT- 2011/07/07 06:00
MHDA- 2012/01/06 06:00
CRDT- 2011/07/07 06:00
PHST- 2011/07/07 06:00 [entrez]
PHST- 2011/07/07 06:00 [pubmed]
PHST- 2012/01/06 06:00 [medline]
PST - ppublish
SO  - Singapore Med J. 2011 Jun;52(6):421-7.


PMID- 21731859
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 2229-5488 (Electronic)
IS  - 2229-3485 (Linking)
VI  - 2
IP  - 2
DP  - 2011 Apr
TI  - The Nuremberg Code-A critique.
PG  - 72-6
LID - 10.4103/2229-3485.80371 [doi]
AB  - The Nuremberg Code drafted at the end of the Doctor's trial in Nuremberg 1947 has
      been hailed as a landmark document in medical and research ethics. Close
      examination of this code reveals that it was based on the Guidelines for Human
      Experimentation of 1931. The resemblance between these documents is uncanny. It
      is unfortunate that the authors of the Nuremberg Code passed it off as their
      original work. There is evidence that the defendants at the trial did request
      that their actions be judged on the basis of the 1931 Guidelines, in force in
      Germany. The prosecutors, however, ignored the request and tried the defendants
      for crimes against humanity, and the judges included the Nuremberg Code as a part
      of the judgment. Six of ten principles in Nuremberg Code are derived from the
      1931 Guidelines, and two of four newly inserted principles are open to
      misinterpretation. There is little doubt that the Code was prepared after
      studying the Guidelines, but no reference was made to the Guidelines, for reasons
      that are not known. Using the Guidelines as a base document without giving due
      credit is plagiarism; as per our understanding of ethics today, this would be
      considered unethical. The Nuremberg Code has fallen by the wayside; since unlike 
      the Declaration of Helsinki, it is not regularly reviewed and updated. The
      regular updating of some ethics codes is evidence of the evolving nature of human
      ethics.
FAU - Ghooi, Ravindra B
AU  - Ghooi RB
AD  - Bilcare Research Academy, Sai Capital, Senapati Bapat Marg, Pune, Maharashtra,
      India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Perspect Clin Res
JT  - Perspectives in clinical research
JID - 101551517
PMC - PMC3121268
OTO - NOTNLM
OT  - Ethics
OT  - Nuremberg
OT  - guidelines
OT  - human subjects
OT  - research
EDAT- 2011/07/07 06:00
MHDA- 2011/07/07 06:01
CRDT- 2011/07/07 06:00
PHST- 2011/07/07 06:00 [entrez]
PHST- 2011/07/07 06:00 [pubmed]
PHST- 2011/07/07 06:01 [medline]
AID - 10.4103/2229-3485.80371 [doi]
AID - PCR-2-72 [pii]
PST - ppublish
SO  - Perspect Clin Res. 2011 Apr;2(2):72-6. doi: 10.4103/2229-3485.80371.


PMID- 21731858
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 2229-5488 (Electronic)
IS  - 2229-3485 (Linking)
VI  - 2
IP  - 2
DP  - 2011 Apr
TI  - Plagiarism: Why is it such a big issue for medical writers?
PG  - 67-71
LID - 10.4103/2229-3485.80370 [doi]
AB  - Plagiarism is the wrongful presentation of somebody else's work or idea as one's 
      own without adequately attributing it to the source. Most authors know that
      plagiarism is an unethical publication practice. Yet, it is a serious problem in 
      the medical writing arena. Plagiarism is perhaps the commonest ethical issue
      plaguing medical writing. In this article, we highlight the different types of
      plagiarism and address the issues of plagiarism of text, plagiarism of ideas,
      mosaic plagiarism, self-plagiarism, and duplicate publication. An act of
      plagiarism can have several repercussions for the author, the journal in question
      and the publication house as a whole. Sometimes, strict disciplinary action is
      also taken against the plagiarist. The article cites examples of retraction of
      articles, suspension of authors, apology letters from journal editors, and other 
      such actions against plagiarism.
FAU - Das, Natasha
AU  - Das N
AD  - Freelance Medical Writer, Delhi, India.
FAU - Panjabi, Monica
AU  - Panjabi M
LA  - eng
PT  - Journal Article
PL  - India
TA  - Perspect Clin Res
JT  - Perspectives in clinical research
JID - 101551517
PMC - PMC3121267
OTO - NOTNLM
OT  - Action against plagiarism
OT  - duplicate publication
OT  - medical writing
OT  - plagiarism
OT  - unethical publication practice
EDAT- 2011/07/07 06:00
MHDA- 2011/07/07 06:01
CRDT- 2011/07/07 06:00
PHST- 2011/07/07 06:00 [entrez]
PHST- 2011/07/07 06:00 [pubmed]
PHST- 2011/07/07 06:01 [medline]
AID - 10.4103/2229-3485.80370 [doi]
AID - PCR-2-67 [pii]
PST - ppublish
SO  - Perspect Clin Res. 2011 Apr;2(2):67-71. doi: 10.4103/2229-3485.80370.


PMID- 21731852
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 2229-5488 (Electronic)
IS  - 2229-3485 (Linking)
VI  - 2
IP  - 2
DP  - 2011 Apr
TI  - Quality of independent review board/ethics committee oversight in clinical trials
      in India.
PG  - 45-7
LID - 10.4103/2229-3485.80364 [doi]
FAU - Pandiya, Anvita
AU  - Pandiya A
AD  - Clinical Research - Quality, Eli Lilly and Company (India) Pvt. Ltd., Plot No.
      92, Sector 32, Gurgaon - 122 001, Haryana, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Perspect Clin Res
JT  - Perspectives in clinical research
JID - 101551517
PMC - PMC3121261
EDAT- 2011/07/07 06:00
MHDA- 2011/07/07 06:01
CRDT- 2011/07/07 06:00
PHST- 2011/07/07 06:00 [entrez]
PHST- 2011/07/07 06:00 [pubmed]
PHST- 2011/07/07 06:01 [medline]
AID - 10.4103/2229-3485.80364 [doi]
AID - PCR-2-45 [pii]
PST - ppublish
SO  - Perspect Clin Res. 2011 Apr;2(2):45-7. doi: 10.4103/2229-3485.80364.


PMID- 21731089
OWN - NLM
STAT- MEDLINE
DCOM- 20110907
LR  - 20211020
IS  - 0008-5286 (Print)
IS  - 0008-5286 (Linking)
VI  - 52
IP  - 4
DP  - 2011 Apr
TI  - Veterinary medical ethics: an ethicist's commentary on unintended consequences of
      a "downer animal" law.
PG  - 353-6; quiz 359-60
FAU - Rollin, Bernard E
AU  - Rollin BE
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Vet J
JT  - The Canadian veterinary journal = La revue veterinaire canadienne
JID - 0004653
SB  - IM
MH  - *Animal Welfare
MH  - Animals
MH  - Cattle/*injuries
MH  - Ethics, Professional
MH  - Euthanasia, Animal
MH  - *Legislation, Veterinary
MH  - Transportation/*legislation & jurisprudence
MH  - Veterinary Medicine/*ethics
PMC - PMC3058646
EDAT- 2011/07/07 06:00
MHDA- 2011/09/08 06:00
CRDT- 2011/07/07 06:00
PHST- 2011/07/07 06:00 [entrez]
PHST- 2011/07/07 06:00 [pubmed]
PHST- 2011/09/08 06:00 [medline]
PST - ppublish
SO  - Can Vet J. 2011 Apr;52(4):353-6; quiz 359-60.


PMID- 21730984
OWN - NLM
STAT- MEDLINE
DCOM- 20111110
LR  - 20110706
IS  - 1745-655X (Electronic)
IS  - 0197-5897 (Linking)
VI  - 32 Suppl 1
DP  - 2011
TI  - Research in support of health systems transformation in South Africa: the
      experience of the Centre for Health Policy.
PG  - S10-29
LID - 10.1057/jphp.2011.33 [doi]
AB  - We describe the role and experience of the Centre for Health Policy (CHP), a
      university-based research unit established in 1987, in influencing and supporting
      health systems transformation in South Africa over two decades. During 2010, we
      analyzed relevant documents and conducted interviews with 25 key informants.
      CHP's research has contributed directly to health policy development and
      implementation while also changing the way government understood or approached
      policy issues. Key success factors for policy influence are: research quality and
      trustworthiness, strategic alliances and networking, and capacity building. CHP's
      challenges include identifying new funding sources and sustaining a high public
      profile. The lessons for other countries are to: conduct good quality, relevant
      research based on strong ethical values; build and maintain open and honest
      relationships with government; recognize and adapt to changes in the policy
      environment; develop capacity as part of a continuous programme; and seek core
      funding that ensures research independence and public accountability.
FAU - Rispel, Laetitia C
AU  - Rispel LC
AD  - Centre for Health Policy & Medical Research Council Health Policy Research Group,
      School of Public Health, Faculty of Health Sciences, University of the
      Witwatersrand, Johannesburg, Private Bag X3, Wits 2050, Johannesburg, South
      Africa. laetitia.rispel@wits.ac.za
FAU - Doherty, Jane
AU  - Doherty J
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Public Health Policy
JT  - Journal of public health policy
JID - 8006508
SB  - IM
MH  - *Delivery of Health Care
MH  - *Health Policy
MH  - *Health Services Research
MH  - Humans
MH  - South Africa
EDAT- 2011/07/07 06:00
MHDA- 2011/11/11 06:00
CRDT- 2011/07/07 06:00
PHST- 2011/07/07 06:00 [entrez]
PHST- 2011/07/07 06:00 [pubmed]
PHST- 2011/11/11 06:00 [medline]
AID - jphp201133 [pii]
AID - 10.1057/jphp.2011.33 [doi]
PST - ppublish
SO  - J Public Health Policy. 2011;32 Suppl 1:S10-29. doi: 10.1057/jphp.2011.33.


PMID- 21730894
OWN - NLM
STAT- MEDLINE
DCOM- 20111228
LR  - 20110706
IS  - 1536-0911 (Electronic)
IS  - 1536-0903 (Linking)
VI  - 11
IP  - 2
DP  - 2011 Apr
TI  - The analgesic properties of intraoral sucrose: an integrative review.
PG  - 83-92; quiz 93-4
LID - 10.1097/ANC.0b013e318210d043 [doi]
AB  - The treatment of pain is an essential component of the clinical and ethical care 
      of infants. Despite evidence-based practice consensus statements recommending
      that infants receive analgesia during minor painful procedures, numerous studies 
      have shown that procedural pain remains poorly managed in this population. Oral
      sucrose administration has been associated with calming effects and reductions in
      observed pain behaviors with preterm and term infants aged up to 1 year. The
      objective of this integrative review is to synthesize findings from published
      randomized controlled trials evaluating the efficacy and safety of oral sucrose
      as a preprocedural intervention for mild to moderate procedural pain in infants. 
      Overall, studies indicate that oral sucrose is an effective, safe, convenient,
      and immediate-acting analgesic for reducing crying time and significantly
      decreases biobehavioral pain response following painful procedures with infants.
FAU - Hatfield, Linda A
AU  - Hatfield LA
AD  - University of Pennsylvania School of Nursing, Philadelphia, Pennsylvania 19104,
      USA.
FAU - Chang, Karen
AU  - Chang K
FAU - Bittle, Marianne
AU  - Bittle M
FAU - Deluca, Joanne
AU  - Deluca J
FAU - Polomano, Rosemary C
AU  - Polomano RC
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Review
PL  - United States
TA  - Adv Neonatal Care
JT  - Advances in neonatal care : official journal of the National Association of
      Neonatal Nurses
JID - 101125644
RN  - 0 (Analgesics)
RN  - 57-50-1 (Sucrose)
SB  - IM
MH  - Administration, Oral
MH  - Analgesia/methods
MH  - Analgesics/*administration & dosage
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Pain/*drug therapy
MH  - Pain Measurement
MH  - Sucrose/*administration & dosage
EDAT- 2011/07/07 06:00
MHDA- 2011/12/29 06:00
CRDT- 2011/07/07 06:00
PHST- 2011/07/07 06:00 [entrez]
PHST- 2011/07/07 06:00 [pubmed]
PHST- 2011/12/29 06:00 [medline]
AID - 10.1097/ANC.0b013e318210d043 [doi]
AID - 00149525-201104000-00004 [pii]
PST - ppublish
SO  - Adv Neonatal Care. 2011 Apr;11(2):83-92; quiz 93-4. doi:
      10.1097/ANC.0b013e318210d043.


PMID- 21730300
OWN - NLM
STAT- MEDLINE
DCOM- 20110928
LR  - 20160726
IS  - 1524-4563 (Electronic)
IS  - 0194-911X (Linking)
VI  - 58
IP  - 2
DP  - 2011 Aug
TI  - Is it ethical to perform irreversible renal denervation before a trial of low
      sodium intake for treatment-resistant hypertension?
PG  - e9; author reply e10
LID - 10.1161/HYPERTENSIONAHA.111.176297 [doi]
FAU - Turner, Martin J
AU  - Turner MJ
FAU - van Schalkwyk, Johan M
AU  - van Schalkwyk JM
LA  - eng
PT  - Letter
PT  - Research Support, Non-U.S. Gov't
DEP - 20110705
PL  - United States
TA  - Hypertension
JT  - Hypertension (Dallas, Tex. : 1979)
JID - 7906255
SB  - IM
MH  - Denervation/*ethics
MH  - Diet, Sodium-Restricted
MH  - Humans
MH  - Hypertension/diet therapy/*surgery
MH  - Kidney/*innervation/surgery
EDAT- 2011/07/07 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/07/07 06:00
PHST- 2011/07/07 06:00 [entrez]
PHST- 2011/07/07 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - HYPERTENSIONAHA.111.176297 [pii]
AID - 10.1161/HYPERTENSIONAHA.111.176297 [doi]
PST - ppublish
SO  - Hypertension. 2011 Aug;58(2):e9; author reply e10. doi:
      10.1161/HYPERTENSIONAHA.111.176297. Epub 2011 Jul 5.


PMID- 21730106
OWN - NLM
STAT- MEDLINE
DCOM- 20120313
LR  - 20220419
IS  - 1468-6244 (Electronic)
IS  - 0022-2593 (Linking)
VI  - 48
IP  - 9
DP  - 2011 Sep
TI  - What can exome sequencing do for you?
PG  - 580-9
LID - 10.1136/jmedgenet-2011-100223 [doi]
AB  - Recent advances in next-generation sequencing technologies have brought a
      paradigm shift in how medical researchers investigate both rare and common human 
      disorders. The ability cost-effectively to generate genome-wide sequencing data
      with deep coverage in a short time frame is replacing approaches that focus on
      specific regions for gene discovery and clinical testing. While whole genome
      sequencing remains prohibitively expensive for most applications, exome
      sequencing--a technique which focuses on only the protein-coding portion of the
      genome--places many advantages of the emerging technologies into researchers'
      hands. Recent successes using this technology have uncovered genetic defects with
      a limited number of probands regardless of shared genetic heritage, and are
      changing our approach to Mendelian disorders where soon all causative variants,
      genes and their relation to phenotype will be uncovered. The expectation is that,
      in the very near future, this technology will enable us to identify all the
      variants in an individual's personal genome and, in particular, clinically
      relevant alleles. Beyond this, whole genome sequencing is also expected to bring 
      a major shift in clinical practice in terms of diagnosis and understanding of
      diseases, ultimately enabling personalised medicine based on one's genome. This
      paper provides an overview of the current and future use of next generation
      sequencing as it relates to whole exome sequencing in human disease by focusing
      on the technical capabilities, limitations and ethical issues associated with
      this technology in the field of genetics and human disease.
FAU - Majewski, Jacek
AU  - Majewski J
AD  - McGill University and Genome Quebec Innovation Centre, Montreal, Canada.
FAU - Schwartzentruber, Jeremy
AU  - Schwartzentruber J
FAU - Lalonde, Emilie
AU  - Lalonde E
FAU - Montpetit, Alexandre
AU  - Montpetit A
FAU - Jabado, Nada
AU  - Jabado N
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110705
PL  - England
TA  - J Med Genet
JT  - Journal of medical genetics
JID - 2985087R
SB  - IM
MH  - Animals
MH  - *Exome
MH  - *Genetic Predisposition to Disease
MH  - Genetic Variation
MH  - Genome
MH  - *Genome-Wide Association Study
MH  - Humans
MH  - Mutation
MH  - Neoplasms/genetics
MH  - Sequence Analysis, DNA/*methods
EDAT- 2011/07/07 06:00
MHDA- 2012/03/14 06:00
CRDT- 2011/07/07 06:00
PHST- 2011/07/07 06:00 [entrez]
PHST- 2011/07/07 06:00 [pubmed]
PHST- 2012/03/14 06:00 [medline]
AID - jmedgenet-2011-100223 [pii]
AID - 10.1136/jmedgenet-2011-100223 [doi]
PST - ppublish
SO  - J Med Genet. 2011 Sep;48(9):580-9. doi: 10.1136/jmedgenet-2011-100223. Epub 2011 
      Jul 5.


PMID- 21730081
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20211020
IS  - 1740-7753 (Electronic)
IS  - 1740-7745 (Linking)
VI  - 8
IP  - 3
DP  - 2011 Jun
TI  - Providing the results of research to participants: a mixed-method study of the
      benefits and challenges of a consultative approach.
PG  - 330-41
LID - 10.1177/1740774511403514 [doi]
AB  - BACKGROUND: How best to provide the findings of research to study participants
      remains poorly understood. PURPOSE: We aimed to develop, deliver, and evaluate a 
      consultative approach to inform provision of feedback about research findings to 
      participants in the Oracle Children Study (OCS). The OCS had identified adverse
      outcomes for some children whose mothers had been prescribed antibiotics as part 
      of a trial in pregnancy. METHODS: An iterative process, including focus groups
      with OCS participants and consultation with other OCS stakeholders, was used to
      inform the development of a feedback package, including a results leaflet, for
      OCS participants. A questionnaire survey of participants' reactions to receiving 
      the results leaflet was conducted. The Kolmogorov-Smirnov two-sample test was
      used to compare responses between different groups of respondents. Analysis of
      open-ended comments on the questionnaire was based on the constant comparative
      method. RESULTS: Three focus groups with study participants provided insight into
      the potential emotional impact of receiving the results and into how the results 
      might most clearly be explained. Negotiations with other stakeholders identified 
      other priorities, including the need for scientific credibility. These multiple
      needs had to be balanced. The results leaflet was posted to all 4676 UK OCS
      participants. Survey responses were received from 1124 (25%) of participants.
      They indicated that the feedback was mostly well received by participants. Those 
      whose children were affected by conditions associated with increased risk from
      trial participation were more likely to experience emotional distress on
      receiving the trial results, but there was also evidence of some other
      unanticipated impacts. LIMITATIONS: This study is limited by the low response
      rate to the survey. CONCLUSIONS: Important lessons can be learned from using a
      consultative approach to developing feedback about research results for study
      participants. Especially where the findings are unwelcome, feedback development
      may involve methodological, ethical, emotional, and practical challenges, be
      resource-intensive, and need early planning.
FAU - Dixon-Woods, Mary
AU  - Dixon-Woods M
AD  - Department of Health Sciences, University of Leicester, UK. md11@le.ac.uk
FAU - Tarrant, Carolyn
AU  - Tarrant C
FAU - Jackson, Clare J
AU  - Jackson CJ
FAU - Jones, David R
AU  - Jones DR
FAU - Kenyon, Sara
AU  - Kenyon S
LA  - eng
GR  - DRF-2009-02-67/DH_/Department of Health/United Kingdom
GR  - G9226450/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Trials
JT  - Clinical trials (London, England)
JID - 101197451
RN  - 0 (Anti-Bacterial Agents)
RN  - 63937KV33D (Erythromycin)
RN  - 74469-00-4 (Amoxicillin-Potassium Clavulanate Combination)
SB  - IM
MH  - Amoxicillin-Potassium Clavulanate Combination/therapeutic use
MH  - Anti-Bacterial Agents/therapeutic use
MH  - *Disclosure
MH  - Erythromycin/therapeutic use
MH  - Feedback
MH  - Female
MH  - Fetal Membranes, Premature Rupture/drug therapy
MH  - Focus Groups
MH  - Humans
MH  - Pregnancy
MH  - Pregnancy Complications
MH  - *Referral and Consultation
MH  - Research Subjects/*psychology
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
EDAT- 2011/07/07 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/07 06:00
PHST- 2011/07/07 06:00 [entrez]
PHST- 2011/07/07 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 8/3/330 [pii]
AID - 10.1177/1740774511403514 [doi]
PST - ppublish
SO  - Clin Trials. 2011 Jun;8(3):330-41. doi: 10.1177/1740774511403514.


PMID- 21730078
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20211020
IS  - 1740-7753 (Electronic)
IS  - 1740-7745 (Linking)
VI  - 8
IP  - 3
DP  - 2011 Jun
TI  - Randomized controlled trial of a collaborative care intervention to manage
      cancer-related symptoms: lessons learned.
PG  - 298-310
LID - 10.1177/1740774511402368 [doi]
AB  - BACKGROUND: Collaborative care interventions to treat depression have begun to be
      tested in settings outside of primary care. However, few studies have expanded
      the collaborative care model to other settings and targeted comorbid physical
      symptoms of depression. PURPOSE: The aims of this report were to: (1) describe
      the design and methods of a trial testing the efficacy of a stepped collaborative
      care intervention designed to manage cancer-related symptoms and improve overall 
      quality of life in patients diagnosed with hepatobiliary carcinoma; and (2) share
      the lessons learned during the design, implementation, and evaluation of the
      trial. METHODS: The trial was a phase III randomized controlled trial testing the
      efficacy of a stepped collaborative care intervention to reduce depression, pain,
      and fatigue in patients diagnosed with advanced cancer. The intervention was
      compared to an enhanced usual care arm. The primary outcomes included the Center 
      for Epidemiological Studies-Depression scale, Brief Pain Inventory, and
      Functional Assessment of Cancer Therapy (FACT)-Fatigue, and the
      FACT-Hepatobiliary. Sociodemographic and disease-specific characteristics were
      recorded from the medical record; Natural Killer cells and cytokines that are
      associated with these symptoms and with disease progression were assayed from
      serum. RESULTS: and Discussion The issues addressed include: (1) development of
      collaborative care in the context of oncology (e.g., timing of the intervention, 
      tailoring of the intervention, ethical issues regarding randomization of
      patients, and changes in medical treatment over the course of the study); (2) use
      of a website by chronically ill populations (e.g., design and access to the
      website, development of the website and intervention, ethical issues associated
      with website development, website usage, and unanticipated costs associated with 
      website development); (3) evaluation of the efficacy of intervention (e.g.,
      patient preferences, proxy raters, changes in medical treatment, and inclusion of
      biomarkers as endpoints); and (4) analyses and interpretation of the intervention
      (e.g., confounding factors, dose and active ingredients, and risks and benefits
      of collaborative care interventions in chronically ill patients). LIMITATIONS:
      The limitations to the study, although not fully realized at this time as the
      trial is ongoing, include: (1) heterogeneity of the diagnoses and treatments of
      participants; and (2) inclusion of caregivers as proxy raters but not as
      participants in the intervention. CONCLUSIONS: Collaborative care interventions
      to manage multiple symptoms in a tertiary cancer center are feasible. However,
      researchers designing and implementing interventions that are web-based, target
      multiple symptoms, and for oncology patients may benefit from previous
      experiences.
FAU - Steel, Jennifer
AU  - Steel J
AD  - Department of Surgery and Psychiatry, University of Pittsburgh School of
      Medicine, PA, USA. steeljl@upmc.edu
FAU - Geller, David A
AU  - Geller DA
FAU - Tsung, Allan
AU  - Tsung A
FAU - Marsh, J Wallis
AU  - Marsh JW
FAU - Dew, Mary Amanda
AU  - Dew MA
FAU - Spring, Michael
AU  - Spring M
FAU - Grady, Jonathan
AU  - Grady J
FAU - Likumahuwa, Sonja
AU  - Likumahuwa S
FAU - Dunlavy, Andrea
AU  - Dunlavy A
FAU - Youssef, Michael
AU  - Youssef M
FAU - Antoni, Michael
AU  - Antoni M
FAU - Butterfield, Lisa H
AU  - Butterfield LH
FAU - Schulz, Richard
AU  - Schulz R
FAU - Day, Richard
AU  - Day R
FAU - Helgeson, Vicki
AU  - Helgeson V
FAU - Kim, Kevin H
AU  - Kim KH
FAU - Gamblin, T Clark
AU  - Gamblin TC
LA  - eng
GR  - R21 CA127046/CA/NCI NIH HHS/United States
GR  - K07 CA118576/CA/NCI NIH HHS/United States
GR  - NCI5K07CA118576-02/CA/NCI NIH HHS/United States
GR  - K07CA118576-04S1/CA/NCI NIH HHS/United States
GR  - KL2 TR000146/TR/NCATS NIH HHS/United States
GR  - UL1 TR000005/TR/NCATS NIH HHS/United States
GR  - 1R21CA127046-01A1/CA/NCI NIH HHS/United States
PT  - Clinical Trial, Phase III
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - Clin Trials
JT  - Clinical trials (London, England)
JID - 101197451
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Carcinoma, Hepatocellular/*complications/*psychology
MH  - *Cooperative Behavior
MH  - Depression/*prevention & control
MH  - Fatigue/*prevention & control
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Liver Neoplasms/*complications/*psychology
MH  - Male
MH  - Middle Aged
MH  - Pain/*prevention & control
MH  - Patient Care Management/*organization & administration
MH  - Quality of Life
MH  - Research Design
MH  - Severity of Illness Index
MH  - Young Adult
PMC - PMC3404514
MID - NIHMS389915
EDAT- 2011/07/07 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/07 06:00
PHST- 2011/07/07 06:00 [entrez]
PHST- 2011/07/07 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 8/3/298 [pii]
AID - 10.1177/1740774511402368 [doi]
PST - ppublish
SO  - Clin Trials. 2011 Jun;8(3):298-310. doi: 10.1177/1740774511402368.


PMID- 21730077
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20191210
IS  - 1740-7753 (Electronic)
IS  - 1740-7745 (Linking)
VI  - 8
IP  - 3
DP  - 2011 Jun
TI  - The 6-MP versus placebo clinical trial in acute leukemia.
PG  - 288-97
LID - 10.1177/1740774511407358 [doi]
AB  - BACKGROUND: This article gives the status of clinical cancer research in the
      1950's-1960's and tells the story of the development and conduct of the
      6-mercaptopurine (6-MP) versus placebo clinical trial in acute leukemia through
      the initiation, design, conduct and analysis stages, with emphasis on the ethical
      aspects of randomizing patients to 6-MP or placebo when in remission. PURPOSE:
      The specific objective was to compare the lengths of remission for patients
      receiving 6-MP or placebo after achieving complete or partial remission from
      steroid treatment. METHODS: A randomized, double-blind, placebo controlled
      sequential study was conducted in which patients were paired by remission status 
      at each of the eleven institutions participating in the study, and randomized to 
      6-MP or placebo within each pair of patients. A preference for 6-MP or placebo
      was recorded depending on which patient in the pair had the longer remission. The
      preferences were plotted according to a restricted sequential procedure devised
      by Peter Armitage and, depending on which boundary of the design was crossed, a
      statistically significant difference could be declared favoring 6-MP, placebo or 
      no preference. CONCLUSIONS: The trial established the efficacy of 6-MP for
      maintaining longer remissions in acute leukemia and led to the concept of
      'adjuvant chemotherapy', namely that patients with minimal disease have a
      substantially better response to chemotherapy than patients with advanced
      disease, a concept that has been followed in many other forms of cancer.
      Statistically, the fact that many patients were still in remission when the study
      was stopped (i.e. the length of remission data for these patients was 'right
      censored') led to the development of a generalized Wilcoxon test and was an
      important influence on Cox's development of the proportional hazards model. The
      trial had an innovative design in the early 1960's and has been an important
      influence on subsequent clinical research in cancer and statistical research in
      survival analysis.
FAU - Gehan, Edmund A
AU  - Gehan EA
AD  - Lombardi Comprehensive Cancer Center, Georgetown University Medical Center,
      Washington, DC, USA. gehane@georgetown.edu
FAU - Freireich, Emil J
AU  - Freireich EJ
LA  - eng
GR  - 2P30 CA051008-17/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - Clin Trials
JT  - Clinical trials (London, England)
JID - 101197451
RN  - 0 (Antimetabolites, Antineoplastic)
RN  - 0 (Placebos)
RN  - E7WED276I5 (Mercaptopurine)
SB  - IM
MH  - Antimetabolites, Antineoplastic/metabolism/*therapeutic use
MH  - Double-Blind Method
MH  - Humans
MH  - Mercaptopurine/metabolism/*therapeutic use
MH  - Outcome Assessment, Health Care
MH  - Placebos
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*drug therapy
MH  - Proportional Hazards Models
MH  - Remission Induction
EDAT- 2011/07/07 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/07 06:00
PHST- 2011/07/07 06:00 [entrez]
PHST- 2011/07/07 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 8/3/288 [pii]
AID - 10.1177/1740774511407358 [doi]
PST - ppublish
SO  - Clin Trials. 2011 Jun;8(3):288-97. doi: 10.1177/1740774511407358.


PMID- 21728389
OWN - NLM
STAT- MEDLINE
DCOM- 20120106
LR  - 20170214
IS  - 1533-0338 (Electronic)
IS  - 1533-0338 (Linking)
VI  - 10
IP  - 4
DP  - 2011 Aug
TI  - Assessment of pulmonary fibrosis after radiotherapy (RT) in breast conserving
      surgery: comparison between conventional external beam RT (EBRT) and
      intraoperative RT with electrons (ELIOT).
PG  - 323-9
AB  - The aim of this study was to assess the frequency and the grade of RT-induced
      pulmonary fibrosis in patients who underwent EBRT compared to patients who
      underwent ELIOT. One-hundred-seventy-eight patients enrolled in a prospective
      randomized phase III trial to compare the efficacy of ELIOT (a single dose of 21 
      Gy prescribed at the 90% isodose) versus EBRT (50 Gy to the whole breast plus a
      10 Gy boost to the tumour bed), underwent a spiral 16-detector row Computed
      Tomography (CT) examination to assess RT-induced pulmonary fibrosis: 83 patients 
      in the EBRT arm and 95 in the ELIOT arm. All patients (age range 48-75 years)
      were affected by unicentric infiltrating carcinoma of the breast with diameter < 
      2.5 cm. This study was approved by our Institutional Ethical Committee and
      informed consent was obtained from each patient. Two observers, blinded to
      patient's randomization, independently evaluated each CT examination and assigned
      a fibrosis score (Grades 0 to 3). Inter-observer agreement for the fibrosis score
      was evaluated and a consensus between observers was obtained. Differences in
      fibrosis score between the two arms were evaluated by Chi Square test and Odds
      Ratio (OR) with 95% Confidence Intervals (CI). Pulmonary fibrosis was diagnosed
      in 42 patients (23.6%): 38 (90%) were in the EBRT arm and 4 (10%) in the ELIOT
      arm (p < 0.0001); twenty-six of them were Grade 1 (one ELIOT), fifteen were Grade
      2 (three ELIOT) and one was Grade 3. The post-radiotherapy risk in the EBRT arm
      to develop at least Grade 1 fibrosis was 19 times higher than in the ELIOT one
      (OR: 19.20; 95%CI: 6.46-57.14) and 6 times higher to develop at least Grade 2
      (OR: 5.70; 95%CI: 1.56-20.76). In conclusion, CT detected pulmonary fibrosis in
      patients treated with ELIOT is significantly less frequent compared to patients
      treated with EBRT.
FAU - Rampinelli, C
AU  - Rampinelli C
AD  - Division of Radiology, European Institute of Oncology, 20141 Milan, Italy.
      cristiano.rampinelli@ieo.it
FAU - Bellomi, M
AU  - Bellomi M
FAU - Ivaldi, G B
AU  - Ivaldi GB
FAU - Intra, M
AU  - Intra M
FAU - Raimondi, S
AU  - Raimondi S
FAU - Meroni, S
AU  - Meroni S
FAU - Orecchia, R
AU  - Orecchia R
FAU - Veronesi, U
AU  - Veronesi U
LA  - eng
PT  - Clinical Trial, Phase III
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Technol Cancer Res Treat
JT  - Technology in cancer research & treatment
JID - 101140941
SB  - IM
MH  - Aged
MH  - Breast Neoplasms/*radiotherapy/surgery
MH  - Carcinoma/complications/*radiotherapy
MH  - Electrons/*therapeutic use
MH  - Female
MH  - Humans
MH  - Mastectomy, Segmental
MH  - Middle Aged
MH  - Pulmonary Fibrosis/*etiology/*pathology
MH  - Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted/adverse effects
MH  - Radiotherapy, Conformal/adverse effects
EDAT- 2011/07/07 06:00
MHDA- 2012/01/10 06:00
CRDT- 2011/07/07 06:00
PHST- 2011/07/07 06:00 [entrez]
PHST- 2011/07/07 06:00 [pubmed]
PHST- 2012/01/10 06:00 [medline]
AID - c4315/Assessment-of-Pulmonary-Fibrosis-after-Radiotherapy-RT-in-Breast-Conserving
      -Surgery-Comparison-between-Conventional-External-Beam-RT-EBRT-and-Intraoperative
      -RT-with-Electrons-ELIOT-323-329-p17872.html [pii]
AID - 10.7785/tcrt.2012.500209 [doi]
PST - ppublish
SO  - Technol Cancer Res Treat. 2011 Aug;10(4):323-9. doi: 10.7785/tcrt.2012.500209.


PMID- 21728033
OWN - NLM
STAT- MEDLINE
DCOM- 20120229
LR  - 20220318
IS  - 1557-1904 (Electronic)
IS  - 1557-1890 (Linking)
VI  - 6
IP  - 4
DP  - 2011 Dec
TI  - Immunosuppressive effects of opioids--clinical relevance.
PG  - 490-502
LID - 10.1007/s11481-011-9290-7 [doi]
AB  - Opioid-induced immunosuppression has been demonstrated in cell culture
      experiments and in animal models. This is in striking contrast to the paucity of 
      confirmatory studies in humans. This review describes the basic pharmacokinetics 
      and -dynamics of opioid use in patients. It summarizes the major findings on
      opioid use and infectious complications in intensive care unit (ICU) patients, in
      patients with acute or chronic non-malignant pain, and in intravenous drug users 
      (IDU). The limitations of studies in each area are discussed. For example,
      ethical concerns may complicate randomized placebo-controlled trials (RCT) in
      acute postoperative pain and for a large part of ICU patients. Importantly, most 
      studies in patients with chronic (non-malignant) pain only inadequately report
      infectious complications in relation to opioid use since their incidence is
      usually not considered to be drug related. Infectious complications in IDUs are
      very frequent but cannot easily be distinguished from risk behavior or risk
      environment. In summary, convincing clinical evidence is lacking that opioids per
      se increase the rate of infectious complications in most patient categories. From
      a clinical standpoint, important unresolved issues are i) selection of relevant
      animal models, ii) opioid selection and discontinuation, and iii) the role of
      coexisting diseases and concomitant other medications.
FAU - Brack, Alexander
AU  - Brack A
AD  - Klinik und Poliklinik fur Anasthesiologie, Zentrum Operative Medizin,
      Universitatsklinikum Wurzburg, Oberdurrbacher Strasse 6, 97080 Wurzburg, Germany.
      brack_a@klinik.uni-wuerzburg.de
FAU - Rittner, Heike L
AU  - Rittner HL
FAU - Stein, Christoph
AU  - Stein C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110705
PL  - United States
TA  - J Neuroimmune Pharmacol
JT  - Journal of neuroimmune pharmacology : the official journal of the Society on
      NeuroImmune Pharmacology
JID - 101256586
RN  - 0 (Analgesics, Opioid)
SB  - IM
MH  - Analgesics, Opioid/*adverse effects/*immunology
MH  - Animals
MH  - Humans
MH  - Immune System/*drug effects
MH  - Infections/epidemiology/*etiology
MH  - Opioid-Related Disorders/*complications/immunology
EDAT- 2011/07/06 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/07/06 06:00
PHST- 2011/05/18 00:00 [received]
PHST- 2011/06/26 00:00 [accepted]
PHST- 2011/07/06 06:00 [entrez]
PHST- 2011/07/06 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - 10.1007/s11481-011-9290-7 [doi]
PST - ppublish
SO  - J Neuroimmune Pharmacol. 2011 Dec;6(4):490-502. doi: 10.1007/s11481-011-9290-7.
      Epub 2011 Jul 5.


PMID- 21727832
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20110705
IS  - 0966-0461 (Print)
IS  - 0966-0461 (Linking)
VI  - 20
IP  - 12
DP  - 2011 Jun 24-Jul 7
TI  - Incontinence in patients with dementia.
PG  - 721-5
AB  - The high prevalence of incontinence in dementia sufferers will only increase as
      the population ages (Alzheimer's Society, 2007), but the evidence-based knowledge
      for management of these long-term disorders combined is lacking (Hagglund, 2010).
      Management techniques for incontinence need to be developed to ensure that
      dementia patients receive the best care, as current methods such as behavioural
      techniques may not be appropriate for people with limited cognitive function.
      This article will address issues that arise with current incontinence management 
      for dementia sufferers and possible courses of action to tailor them more
      specifically to those people with cognitive impairment. Quite often, incontinence
      is just managed with incontinence pads and treatment is not discussed, which can 
      have detrimental effects on the patient (Omli et al, 2010). Nurses have an
      important role in incontinence treatment and can change this misuse of
      incontinence pads and ensuring a holistic approach to care will help when
      treating a patient with dementia. Ethical and legal issues will also be discussed
      as they must be considered when providing holistic care.
FAU - Price, Harriet
AU  - Price H
AD  - Buckinghamshire New University, Uxbridge Campus.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Nurs
JT  - British journal of nursing (Mark Allen Publishing)
JID - 9212059
MH  - Dementia/*complications/nursing/psychology
MH  - Fecal Incontinence/diagnosis/*etiology/*therapy
MH  - Humans
MH  - *Nurse's Role
MH  - Urinary Incontinence/diagnosis/*etiology/*therapy
EDAT- 2011/07/06 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/07/06 06:00
PHST- 2011/07/06 06:00 [entrez]
PHST- 2011/07/06 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 10.12968/bjon.2011.20.12.721 [doi]
PST - ppublish
SO  - Br J Nurs. 2011 Jun 24-Jul 7;20(12):721-5. doi: 10.12968/bjon.2011.20.12.721.


PMID- 21727246
OWN - NLM
STAT- MEDLINE
DCOM- 20111027
LR  - 20110830
IS  - 1097-6817 (Electronic)
IS  - 0194-5998 (Linking)
VI  - 145
IP  - 3
DP  - 2011 Sep
TI  - Ethics: the joy of practice.
PG  - 363-4
LID - 10.1177/0194599811414397 [doi]
AB  - Dr John J. Conley was an integral part of the house of surgery in the latter part
      of the 20th century. Conley placed the ethical values of practice at the
      forefront of his teachings and transcribed many valuable lessons in his writings.
      In 1993, he wrote his version of the Hippocratic Oath outlining 12 important
      principles. Those principles are revisited here as a way to celebrate the joy of 
      the calling that is medical practice. In addition, 7 new elements are added as a 
      way to enhance that joy in the light of 21st-century medicine. The uplifting
      experience found in a career filled with ethical conduct is the legacy we should 
      all strive to achieve.
FAU - Healy, Gerald B
AU  - Healy GB
AD  - Harvard Medical School, Boston, MA, USA. gerald_healy@meei.harvard.edu
LA  - eng
PT  - Biography
PT  - Historical Article
PT  - Journal Article
DEP - 20110704
PL  - England
TA  - Otolaryngol Head Neck Surg
JT  - Otolaryngology--head and neck surgery : official journal of American Academy of
      Otolaryngology-Head and Neck Surgery
JID - 8508176
SB  - IM
MH  - Ethics, Medical/*history
MH  - Hippocratic Oath
MH  - History, 20th Century
MH  - Humans
MH  - Moral Obligations
MH  - Philosophy, Medical/*history
PS  - Conley JJ
FPS - Conley, John J
EDAT- 2011/07/06 06:00
MHDA- 2011/10/28 06:00
CRDT- 2011/07/06 06:00
PHST- 2011/07/06 06:00 [entrez]
PHST- 2011/07/06 06:00 [pubmed]
PHST- 2011/10/28 06:00 [medline]
AID - 0194599811414397 [pii]
AID - 10.1177/0194599811414397 [doi]
PST - ppublish
SO  - Otolaryngol Head Neck Surg. 2011 Sep;145(3):363-4. doi: 10.1177/0194599811414397.
      Epub 2011 Jul 4.


PMID- 21727137
OWN - NLM
STAT- MEDLINE
DCOM- 20111102
LR  - 20211020
IS  - 1471-2970 (Electronic)
IS  - 0962-8436 (Linking)
VI  - 366
IP  - 1575
DP  - 2011 Aug 12
TI  - Immunological considerations for embryonic and induced pluripotent stem cell
      banking.
PG  - 2312-22
LID - 10.1098/rstb.2011.0030 [doi]
AB  - Recent advances in stem cell technology have generated enthusiasm for their
      potential to study and treat a diverse range of human disease. Pluripotent human 
      stem cells for therapeutic use may, in principle, be obtained from two sources:
      embryonic stem cells (hESCs), which are capable of extensive self-renewal and
      expansion and have the potential to differentiate into any somatic tissue, and
      induced pluripotent stem cells (iPSCs), which are derived from differentiated
      tissue such as adult skin fibroblasts and appear to have the same properties and 
      potential, but their generation is not dependent upon a source of embryos. The
      likelihood that clinical transplantation of hESC- or iPSC-derived tissues from an
      unrelated (allogeneic) donor that express foreign human leucocyte antigens (HLA) 
      may undergo immunological rejection requires the formulation of strategies to
      attenuate the host immune response to transplanted tissue. In clinical practice, 
      individualized iPSC tissue derived from the intended recipient offers the
      possibility of personalized stem cell therapy in which graft rejection would not 
      occur, but the logistics of achieving this on a large scale are problematic owing
      to relatively inefficient reprogramming techniques and high costs. The creation
      of stem cell banks comprising HLA-typed hESCs and iPSCs is a strategy that is
      proposed to overcome the immunological barrier by providing HLA-matched
      (histocompatible) tissue for the target population. Estimates have shown that a
      stem cell bank containing around 10 highly selected cell lines with conserved
      homozygous HLA haplotypes would provide matched tissue for the majority of the UK
      population. These simulations have practical, financial, political and ethical
      implications for the establishment and design of stem cell banks incorporating
      cell lines with HLA types that are compatible with different ethnic populations
      throughout the world.
FAU - Taylor, Craig J
AU  - Taylor CJ
AD  - Histocompatibility and Immunogenetics, Tissue Typing Laboratory, Cambridge
      University Teaching Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Hills
      Road, Cambridge CB2 0QQ, UK. craig.taylor@addenbrookes
FAU - Bolton, Eleanor M
AU  - Bolton EM
FAU - Bradley, J Andrew
AU  - Bradley JA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Philos Trans R Soc Lond B Biol Sci
JT  - Philosophical transactions of the Royal Society of London. Series B, Biological
      sciences
JID - 7503623
SB  - IM
MH  - *Biological Specimen Banks
MH  - Embryonic Stem Cells/*physiology
MH  - Histocompatibility
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*physiology
MH  - Specimen Handling
PMC - PMC3130422
EDAT- 2011/07/06 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/07/06 06:00
PHST- 2011/07/06 06:00 [entrez]
PHST- 2011/07/06 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
AID - 366/1575/2312 [pii]
AID - 10.1098/rstb.2011.0030 [doi]
PST - ppublish
SO  - Philos Trans R Soc Lond B Biol Sci. 2011 Aug 12;366(1575):2312-22. doi:
      10.1098/rstb.2011.0030.


PMID- 21726926
OWN - NLM
STAT- MEDLINE
DCOM- 20111206
LR  - 20220408
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 73
IP  - 3
DP  - 2011 Aug
TI  - From consent to institutions: designing adaptive governance for genomic biobanks.
PG  - 367-74
LID - 10.1016/j.socscimed.2011.05.046 [doi]
AB  - Biobanks are increasingly hailed as powerful tools to advance health research.
      The social and ethical challenges associated with the implementation and
      operation of biobanks are equally well-documented. One of the proposed solutions 
      to these challenges involves trading off a reduction in the specificity of
      informed consent protocols with an increased emphasis on governance. However,
      little work has gone into formulating what such governance might look like. In
      this paper, we suggest four general principles that should inform biobank
      governance and illustrate the enactment of these principles in a proposed
      governance model for a particular population-scale biobank, the British Columbia 
      (BC) Generations Project. We begin by outlining four principles that we see as
      necessary for informing sustainable and effective governance of biobanks: (1)
      recognition of research participants and publics as a collective body, (2)
      trustworthiness, (3) adaptive management, and (4) fit between the nature of a
      particular biobank and the specific structural elements of governance adopted.
      Using the BC Generations Project as a case study, we then offer as a working
      model for further discussion the outlines of a proposed governance structure
      enacting these principles. Ultimately, our goal is to design an adaptive
      governance approach that can protect participant interests as well as promote
      effective translational health sciences.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - O'Doherty, Kieran C
AU  - O'Doherty KC
AD  - University of Guelph, Psychology, MacKinnon Ext. (Bldg. 154), 87 Trent Lane,
      Guelph, Ontario, Canada. kieran.odoherty@uoguelph.ca
FAU - Burgess, Michael M
AU  - Burgess MM
FAU - Edwards, Kelly
AU  - Edwards K
FAU - Gallagher, Richard P
AU  - Gallagher RP
FAU - Hawkins, Alice K
AU  - Hawkins AK
FAU - Kaye, Jane
AU  - Kaye J
FAU - McCaffrey, Veronica
AU  - McCaffrey V
FAU - Winickoff, David E
AU  - Winickoff DE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110702
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - British Columbia
MH  - Community Participation
MH  - *Databases, Genetic
MH  - Genetic Research/ethics
MH  - *Genome
MH  - Humans
MH  - Informed Consent
MH  - Trust
EDAT- 2011/07/06 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/06 06:00
PHST- 2010/08/20 00:00 [received]
PHST- 2011/05/23 00:00 [revised]
PHST- 2011/05/31 00:00 [accepted]
PHST- 2011/07/06 06:00 [entrez]
PHST- 2011/07/06 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0277-9536(11)00336-4 [pii]
AID - 10.1016/j.socscimed.2011.05.046 [doi]
PST - ppublish
SO  - Soc Sci Med. 2011 Aug;73(3):367-74. doi: 10.1016/j.socscimed.2011.05.046. Epub
      2011 Jul 2.


PMID- 21726528
OWN - NLM
STAT- MEDLINE
DCOM- 20111003
LR  - 20181201
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 411
IP  - 2
DP  - 2011 Jul 29
TI  - Colonization of collagen scaffolds by adipocytes derived from mesenchymal stem
      cells of the common marmoset monkey.
PG  - 317-22
LID - 10.1016/j.bbrc.2011.06.134 [doi]
AB  - In regenerative medicine, human cell replacement therapy offers great potential, 
      especially by cell types differentiated from immunologically and ethically
      unproblematic mesenchymal stem cells (MSCs). In terms of an appropriate carrier
      material, collagen scaffolds with homogeneous pore size of 65mum were optimal for
      cell seeding and cultivating. However, before clinical application and
      transplantation of MSC-derived cells in scaffolds, the safety and efficiency, but
      also possible interference in differentiation due to the material must be
      preclinically tested. The common marmoset monkey (Callithrix jacchus) is a
      preferable non-human primate animal model for this aim due to its genetic and
      physiological similarities to the human. Marmoset bone marrow-derived MSCs were
      successfully isolated, cultured and differentiated in suspension into adipogenic,
      osteogenic and chondrogenic lineages by defined factors. The differentiation
      capability could be determined by FACS. Specific marker genes for all three cell 
      types could be detected by RT-PCR. Furthermore, MSCs seeded on collagen I
      scaffolds differentiated in adipogenic lineage showed after 28days of
      differentiation high cell viability and homogenous distribution on the material
      which was validated by calcein AM and EthD staining. As proof of adipogenic
      cells, the intracellular lipid vesicles in the cells were stained with Oil Red O.
      The generation of fat vacuoles was visibly extensive distinguishable and
      furthermore determined on the molecular level by expression of specific marker
      genes. The results of the study proved both the differential potential of
      marmoset MSCs in adipogenic, osteogenic and chondrogenic lineages and the
      suitability of collagen scaffolds as carrier material undisturbing
      differentiation of primate mesenchymal stem cells.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Bernemann, Inga
AU  - Bernemann I
AD  - Institute for Multiphase Processes, Leibniz Universitat Hannover, Hannover,
      Germany. bernemann@imp.uni-hannover.de
FAU - Mueller, Thomas
AU  - Mueller T
FAU - Blasczyk, Rainer
AU  - Blasczyk R
FAU - Glasmacher, Birgit
AU  - Glasmacher B
FAU - Hofmann, Nicola
AU  - Hofmann N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110625
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Collagen Type I)
SB  - IM
MH  - Adipocytes/*cytology/metabolism
MH  - *Adipogenesis
MH  - Animals
MH  - Callithrix
MH  - Cell Separation
MH  - *Collagen Type I
MH  - Mesenchymal Stem Cells/*physiology
MH  - Tissue Engineering/*methods
MH  - *Tissue Scaffolds
EDAT- 2011/07/06 06:00
MHDA- 2011/10/04 06:00
CRDT- 2011/07/06 06:00
PHST- 2011/06/03 00:00 [received]
PHST- 2011/06/21 00:00 [accepted]
PHST- 2011/07/06 06:00 [entrez]
PHST- 2011/07/06 06:00 [pubmed]
PHST- 2011/10/04 06:00 [medline]
AID - S0006-291X(11)01115-6 [pii]
AID - 10.1016/j.bbrc.2011.06.134 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2011 Jul 29;411(2):317-22. doi:
      10.1016/j.bbrc.2011.06.134. Epub 2011 Jun 25.


PMID- 21726441
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20220408
IS  - 1472-6963 (Electronic)
IS  - 1472-6963 (Linking)
VI  - 11
DP  - 2011 Jul 4
TI  - "Fighting the system": families caring for ventilator-dependent children and
      adults with complex health care needs at home.
PG  - 156
LID - 10.1186/1472-6963-11-156 [doi]
AB  - BACKGROUND: An increasing number of individuals with complex health care needs
      now receive life-long and life-prolonging ventilatory support at home. Family
      members often take on the role of primary caregivers. The aim of this study was
      to explore the experiences of families giving advanced care to family members
      dependent on home mechanical ventilation. METHODS: Using qualitative research
      methods, a Grounded Theory influenced approach was used to explore the families' 
      experiences. A total of 15 family members with 11 ventilator-dependent
      individuals (three children and eight adults) were recruited for 10 in-depth
      interviews. RESULTS: The core category, "fighting the system," became the central
      theme as family members were asked to describe their experiences. In addition, we
      identified three subcategories, "lack of competence and continuity", "being
      indispensable" and "worth fighting for". This study revealed no major differences
      in the families' experiences that were dependent on whether the
      ventilator-dependent individual was a child or an adult. CONCLUSIONS: These
      findings show that there is a large gap between family members' expectations and 
      what the community health care services are able to provide, even when almost
      unlimited resources are available. A number of measures are needed to reduce the 
      burden on these family members and to make hospital care at home possible. In the
      future, the gap between what the health care can potentially provide and what
      they can provide in real life will rapidly increase. New proposals to limit the
      extremely costly provision of home mechanical ventilation in Norway will trigger 
      new ethical dilemmas that should be studied further.
FAU - Dybwik, Knut
AU  - Dybwik K
AD  - Department of Anaesthesiology, Nordland Hospital, 8092 Bodo, Norway.
      kdybwik@gmail.com
FAU - Tollali, Terje
AU  - Tollali T
FAU - Nielsen, Erik W
AU  - Nielsen EW
FAU - Brinchmann, Berit S
AU  - Brinchmann BS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110704
PL  - England
TA  - BMC Health Serv Res
JT  - BMC health services research
JID - 101088677
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Caregivers
MH  - Child
MH  - *Consumer Behavior
MH  - *Family
MH  - Female
MH  - *Health Services Needs and Demand
MH  - *Home Care Services
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Middle Aged
MH  - Norway
MH  - *Respiration, Artificial
MH  - Young Adult
PMC - PMC3146406
EDAT- 2011/07/06 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/06 06:00
PHST- 2010/08/25 00:00 [received]
PHST- 2011/07/04 00:00 [accepted]
PHST- 2011/07/06 06:00 [entrez]
PHST- 2011/07/06 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 1472-6963-11-156 [pii]
AID - 10.1186/1472-6963-11-156 [doi]
PST - epublish
SO  - BMC Health Serv Res. 2011 Jul 4;11:156. doi: 10.1186/1472-6963-11-156.


PMID- 21726265
OWN - NLM
STAT- MEDLINE
DCOM- 20140108
LR  - 20130110
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 27
IP  - 2
DP  - 2013 Feb
TI  - The ethics of uterus transplantation.
PG  - 65-73
LID - 10.1111/j.1467-8519.2011.01897.x [doi]
AB  - Human uterus transplantation (UTx) is currently under investigation as a
      treatment for uterine infertility. Without a uterus transplant, the options
      available to women with uterine infertility are adoption or surrogacy; only the
      latter has the potential for a genetically related child. UTx will offer
      recipients the chance of having their own pregnancy. This procedure occurs at the
      intersection of two ethically contentious areas: assisted reproductive
      technologies (ART) and organ transplantation. In relation to organ
      transplantation, UTx lies with composite tissue transplants such as face and limb
      grafts, and shares some of the ethical concerns raised by these non-life saving
      procedures. In relation to ART, UTx represents one more avenue by which a woman
      may seek to meet her reproductive goals, and as with other ART procedures, raises
      questions about the limits of reproductive autonomy. This paper explores the
      ethical issues raised by UTx with a focus on the potential gap between women's
      desires and aspirations about pregnancy and the likely functional outcomes of
      successful UTx.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Catsanos, Ruby
AU  - Catsanos R
AD  - Department of Philosophy, Macquarie University, Sydney, NSW, Australia.
      ruby.catsanos@students.mq.edu.au
FAU - Rogers, Wendy
AU  - Rogers W
FAU - Lotz, Mianna
AU  - Lotz M
LA  - eng
PT  - Journal Article
DEP - 20110704
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Female
MH  - Humans
MH  - Infertility, Female/*surgery
MH  - Informed Consent/ethics
MH  - Organ Transplantation/adverse effects/*ethics
MH  - Personal Autonomy
MH  - Pregnancy
MH  - Quality of Life
MH  - Reproductive Techniques, Assisted/*ethics
MH  - Tissue Donors
MH  - Uterus/*transplantation
EDAT- 2011/07/06 06:00
MHDA- 2014/01/09 06:00
CRDT- 2011/07/06 06:00
PHST- 2011/07/06 06:00 [entrez]
PHST- 2011/07/06 06:00 [pubmed]
PHST- 2014/01/09 06:00 [medline]
AID - 10.1111/j.1467-8519.2011.01897.x [doi]
PST - ppublish
SO  - Bioethics. 2013 Feb;27(2):65-73. doi: 10.1111/j.1467-8519.2011.01897.x. Epub 2011
      Jul 4.


PMID- 21726264
OWN - NLM
STAT- MEDLINE
DCOM- 20140108
LR  - 20211203
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 27
IP  - 2
DP  - 2013 Feb
TI  - Uncertain translation, uncertain benefit and uncertain risk: ethical challenges
      facing first-in-human trials of induced pluripotent stem (ips) cells.
PG  - 89-96
LID - 10.1111/j.1467-8519.2011.01896.x [doi]
AB  - The discovery of induced pluripotent stem (iPS) cells in 2006 was heralded as a
      major breakthrough in stem cell research. Since then, progress in iPS cell
      technology has paved the way towards clinical application, particularly cell
      replacement therapy, which has refueled debate on the ethics of stem cell
      research. However, much of the discourse has focused on questions of moral status
      and potentiality, overlooking the ethical issues which are introduced by the
      clinical testing of iPS cell replacement therapy. First-in-human trials, in
      particular, raise a number of ethical concerns including informed consent,
      subject recruitment and harm minimisation as well as the inherent uncertainty and
      risks which are involved in testing medical procedures on humans for the first
      time. These issues, while a feature of any human research, become more complex in
      the case of iPS cell therapy, given the seriousness of the potential risks, the
      unreliability of available animal models, the vulnerability of the target patient
      group, and the high stakes of such an intensely public area of science. Our paper
      will present a detailed case study of iPS cell replacement therapy for
      Parkinson's disease to highlight these broader ethical and epistemological
      concerns. If we accept that iPS cell technology is fraught with challenges which 
      go far beyond merely refuting the potentiality of the stem cell line, we conclude
      that iPS cell research should not replace, but proceed alongside embryonic and
      adult somatic stem cell research to promote cross-fertilisation of knowledge and 
      better clinical outcomes.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Fung, Ronald K F
AU  - Fung RK
AD  - University of Sydney-Centre for Values, Ethics and the Law in Medicine,
      University of Sydney, Camperdown Sydney New South Wales, Australia.
      rfun6468@uni.sydney.edu.au
FAU - Kerridge, Ian H
AU  - Kerridge IH
LA  - eng
PT  - Journal Article
DEP - 20110704
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*transplantation
MH  - Informed Consent/ethics
MH  - Parkinson Disease/*therapy
MH  - Patient Selection/ethics
MH  - Risk Assessment
MH  - *Risk Management
MH  - Stem Cell Transplantation/*ethics
MH  - Translational Research, Biomedical/*ethics
MH  - *Uncertainty
EDAT- 2011/07/06 06:00
MHDA- 2014/01/09 06:00
CRDT- 2011/07/06 06:00
PHST- 2011/07/06 06:00 [entrez]
PHST- 2011/07/06 06:00 [pubmed]
PHST- 2014/01/09 06:00 [medline]
AID - 10.1111/j.1467-8519.2011.01896.x [doi]
PST - ppublish
SO  - Bioethics. 2013 Feb;27(2):89-96. doi: 10.1111/j.1467-8519.2011.01896.x. Epub 2011
      Jul 4.


PMID- 21726262
OWN - NLM
STAT- MEDLINE
DCOM- 20140123
LR  - 20191210
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 27
IP  - 1
DP  - 2013 Jan
TI  - Understanding doctors' ethical challenges as role virtue conflicts.
PG  - 20-7
LID - 10.1111/j.1467-8519.2011.01893.x [doi]
AB  - This paper argues that doctors' ethical challenges can be usefully conceptualised
      as role virtue conflicts. The hospital environment requires doctors to be
      simultaneously good doctors, good team members, good learners and good employees.
      I articulate a possible set of role virtues for each of these four roles, as a
      basis for a virtue ethics approach to analysing doctors' ethical challenges.
      Using one junior doctor's story, I argue that understanding doctors' ethical
      challenges as role virtue conflicts enables recognition of important moral
      considerations that are overlooked by other approaches to ethical analysis.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - McDougall, Rosalind
AU  - McDougall R
AD  - Centre for Health and Society, Level 4 207 Bouverie St, University of Melbourne, 
      Victoria 3010, Australia. rosjmcdougall@gmail.com
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110704
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - *Conflict, Psychological
MH  - Employment/ethics
MH  - Ethical Analysis
MH  - Humans
MH  - Internship and Residency/ethics
MH  - Medical Errors/*ethics
MH  - Medical Staff, Hospital/*ethics
MH  - Patient Care Team/ethics
MH  - *Physician's Role
MH  - Truth Disclosure/*ethics
MH  - *Virtues
EDAT- 2011/07/06 06:00
MHDA- 2014/01/24 06:00
CRDT- 2011/07/06 06:00
PHST- 2011/07/06 06:00 [entrez]
PHST- 2011/07/06 06:00 [pubmed]
PHST- 2014/01/24 06:00 [medline]
AID - 10.1111/j.1467-8519.2011.01893.x [doi]
PST - ppublish
SO  - Bioethics. 2013 Jan;27(1):20-7. doi: 10.1111/j.1467-8519.2011.01893.x. Epub 2011 
      Jul 4.


PMID- 21726261
OWN - NLM
STAT- MEDLINE
DCOM- 20140108
LR  - 20211020
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 27
IP  - 2
DP  - 2013 Feb
TI  - Is payment a benefit?
PG  - 105-16
LID - 10.1111/j.1467-8519.2011.01892.x [doi]
AB  - What I call 'the standard view' claims that IRBs should not regard financial
      payment as a benefit to subjects for the purpose of risk/benefit assessment.
      Although the standard view is universally accepted, there is little defense of
      that view in the canonical documents of research ethics or the scholarly
      literature. This paper claims that insofar as IRBs should be concerned with the
      interests and autonomy of research subjects, they should reject the standard view
      and adopt 'the incorporation view.' The incorporation view is more consistent
      with the underlying soft-paternalist justification for risk-benefit assessment
      and demonstrates respect for the autonomy of prospective subjects. Adoption of
      the standard view precludes protocols that advance the interests of subjects,
      investigators, and society. After considering several objections to the argument,
      I consider several arguments for the standard view that do not appeal to the
      interests and autonomy of research subjects.
CI  - Published 2011. This article is a US Government work and is in the public domain 
      in the USA.
FAU - Wertheimer, Alan
AU  - Wertheimer A
AD  - Department of Bioethics, National Institutes of Health, Bethesda, Maryland, USA. 
      wertheimera@cc.nih.gov
LA  - eng
GR  - Z99 CL999999/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
DEP - 20110704
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Ethics Committees, Research
MH  - *Ethics, Research
MH  - Humans
MH  - Morals
MH  - Personal Autonomy
MH  - Public Opinion
MH  - Research Subjects/*economics
MH  - *Risk Assessment
MH  - *Salaries and Fringe Benefits
PMC - PMC3189440
MID - NIHMS279300
EDAT- 2011/07/06 06:00
MHDA- 2014/01/09 06:00
CRDT- 2011/07/06 06:00
PHST- 2011/07/06 06:00 [entrez]
PHST- 2011/07/06 06:00 [pubmed]
PHST- 2014/01/09 06:00 [medline]
AID - 10.1111/j.1467-8519.2011.01892.x [doi]
PST - ppublish
SO  - Bioethics. 2013 Feb;27(2):105-16. doi: 10.1111/j.1467-8519.2011.01892.x. Epub
      2011 Jul 4.


PMID- 21726260
OWN - NLM
STAT- MEDLINE
DCOM- 20140123
LR  - 20121210
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 27
IP  - 1
DP  - 2013 Jan
TI  - No ethical bypass of moral status in stem cell research.
PG  - 12-9
LID - 10.1111/j.1467-8519.2011.01891.x [doi]
AB  - Recent advances in reprogramming technology do not bypass the ethical challenge
      of embryo sacrifice. Induced pluripotent stem cell (iPS) research has been and
      almost certainly will continue to be conducted within the context of embryo
      sacrifice. If human embryos have moral status as human beings, then participation
      in iPS research renders one morally complicit in their destruction; if human
      embryos have moral status as mere precursors of human beings, then advocacy of
      iPS research policy that is inhibited by embryo sacrifice concerns renders one
      morally complicit in avoidable harms to persons. Steps may be taken to address
      these complicity concerns, but in the final analysis there is no alternative to
      achieving clarity with respect to the moral status of the human embryo.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Brown, Mark
AU  - Brown M
AD  - University of Wisconsin Colleges - Philosophy, 518 South 7th Avenue, Wausau,
      Wisconsin 54403, United States. mark.brown@uwc.edu
LA  - eng
PT  - Journal Article
DEP - 20110704
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Beginning of Human Life
MH  - *Complicity
MH  - *Embryo, Mammalian
MH  - *Embryonic Stem Cells
MH  - Humans
MH  - *Induced Pluripotent Stem Cells
MH  - Moral Obligations
MH  - *Morals
MH  - Stem Cell Research/*ethics
EDAT- 2011/07/06 06:00
MHDA- 2014/01/24 06:00
CRDT- 2011/07/06 06:00
PHST- 2011/07/06 06:00 [entrez]
PHST- 2011/07/06 06:00 [pubmed]
PHST- 2014/01/24 06:00 [medline]
AID - 10.1111/j.1467-8519.2011.01891.x [doi]
PST - ppublish
SO  - Bioethics. 2013 Jan;27(1):12-9. doi: 10.1111/j.1467-8519.2011.01891.x. Epub 2011 
      Jul 4.


PMID- 21726206
OWN - NLM
STAT- MEDLINE
DCOM- 20111003
LR  - 20130104
IS  - 1365-2141 (Electronic)
IS  - 0007-1048 (Linking)
VI  - 154
IP  - 4
DP  - 2011 Aug
TI  - Milestones in umbilical cord blood transplantation.
PG  - 441-7
LID - 10.1111/j.1365-2141.2011.08598.x [doi]
AB  - Much has been learned about umbilical cord blood (UCB) since the first human cord
      blood transplant was performed back in 1988. Cord blood banks have been
      established worldwide for the collection, cryopreservation and distribution of
      UCB for allogeneic haematopoietic stem cell transplantation. UCB has now become
      one of the most commonly used sources of haematopoietic stem cells for allogeneic
      transplantation. Today, a global network of cord blood banks and transplant
      centres has been established with a large common inventory, allowing for more
      than 20000 transplants worldwide in children and adults with severe
      haematological diseases. Several studies have been published on UCB transplant,
      assessing risk factors such as cell dose and human leucocyte antigen mismatch.
      New strategies are ongoing to facilitate engraftment and reduce
      transplant-related mortality and include the use of reduced-intensity
      conditioning regimen, intra-bone injection of cord blood cells, double cord blood
      transplants or ex vivo expansion of cord blood cells. The absence of ethical
      concern and the unlimited supply of cells explain the increasing interest of
      using UCB for developing regenerative medicine.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Gluckman, Eliane
AU  - Gluckman E
AD  - Eurocord, Assistance publique des hopitaux de Paris (APHP), Institut
      Universitaire d'Hematologie (IUH) Hopital Saint Louis, Paris, France.
      eliane.gluckman@sls.aphp.fr
FAU - Ruggeri, Annalisa
AU  - Ruggeri A
FAU - Volt, Fernanda
AU  - Volt F
FAU - Cunha, Renato
AU  - Cunha R
FAU - Boudjedir, Karim
AU  - Boudjedir K
FAU - Rocha, Vanderson
AU  - Rocha V
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110705
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
SB  - IM
CIN - Br J Haematol. 2012 Dec;159(5):602-4. PMID: 23043219
MH  - Blood Banks/history/organization & administration
MH  - Cord Blood Stem Cell Transplantation/*history/methods/trends
MH  - Donor Selection
MH  - Hematologic Diseases/history/therapy
MH  - Histocompatibility
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
EDAT- 2011/07/06 06:00
MHDA- 2011/10/04 06:00
CRDT- 2011/07/06 06:00
PHST- 2011/07/06 06:00 [entrez]
PHST- 2011/07/06 06:00 [pubmed]
PHST- 2011/10/04 06:00 [medline]
AID - 10.1111/j.1365-2141.2011.08598.x [doi]
PST - ppublish
SO  - Br J Haematol. 2011 Aug;154(4):441-7. doi: 10.1111/j.1365-2141.2011.08598.x. Epub
      2011 Jul 5.


PMID- 21726179
OWN - NLM
STAT- MEDLINE
DCOM- 20120116
LR  - 20200505
IS  - 1619-3997 (Electronic)
IS  - 0300-5577 (Linking)
VI  - 39
IP  - 5
DP  - 2011 Sep
TI  - Historical notes on immaturity. Part 2: surviving against the odds.
PG  - 571-7
LID - 10.1515/jpm.2011.057 [doi]
AB  - Survivors of immaturity of outstanding intelligence include Fortunio Licetus,
      born in 1577, and Isaac Newton, born in 1643. Reliable descriptions began
      appearing around 1820, and over a dozen infants were born weighing under 1000 g
      and before World War II, who developed normally. From 1876 to 2006, the birth
      weight at which half of the infants survived dropped from 2200 to 600 g.
      Statistics depended on how abortion, stillbirth and live birth were defined,
      which differed greatly from country to country. WHO definitions in 1993 required 
      the registration of all infants weighing 500 g (22 complete weeks) or above. This
      definition was not universally adopted, resulting in considerable underreporting.
      Many medical societies issued ethical recommendations concerning the obligatory
      or optional treatment of immature infants. The "window", at which treatment is
      optional has been set at 22-23 weeks (Japan, Germany), 23-24 weeks (UK, USA,
      Canada), or 24-26 weeks (France, Netherlands, Switzerland). Instead of assessing 
      an infant's individual prognosis, and ignoring its gender, co-morbidities, and
      particular cause of premature delivery, these rules frequently relied on
      gestational age alone to initiate or withhold life support.
FAU - Obladen, Michael
AU  - Obladen M
AD  - Department of Neonatology, Charite University Medicine, Berlin, Germany.
      michael.obladen@charite.de
LA  - eng
PT  - Historical Article
PT  - Journal Article
DEP - 20110705
PL  - Germany
TA  - J Perinat Med
JT  - Journal of perinatal medicine
JID - 0361031
SB  - IM
MH  - Birth Weight
MH  - Ethics, Medical
MH  - Famous Persons
MH  - Female
MH  - *Fetal Viability
MH  - History, 16th Century
MH  - History, 17th Century
MH  - History, 18th Century
MH  - History, 19th Century
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Male
MH  - Pregnancy
EDAT- 2011/07/06 06:00
MHDA- 2012/01/17 06:00
CRDT- 2011/07/06 06:00
PHST- 2011/07/06 06:00 [entrez]
PHST- 2011/07/06 06:00 [pubmed]
PHST- 2012/01/17 06:00 [medline]
AID - 10.1515/jpm.2011.057 [doi]
PST - ppublish
SO  - J Perinat Med. 2011 Sep;39(5):571-7. doi: 10.1515/jpm.2011.057. Epub 2011 Jul 5.


PMID- 21726067
OWN - NLM
STAT- MEDLINE
DCOM- 20111031
LR  - 20211020
IS  - 1862-1783 (Electronic)
IS  - 1673-1581 (Linking)
VI  - 12
IP  - 7
DP  - 2011 Jul
TI  - Dilemma of concepts and strategies for the prevention of spread of HIV in
      relation to human behavior, law and human rights.
PG  - 591-610
LID - 10.1631/jzus.B1000434 [doi]
AB  - The new prevalence data regarding the estimated global number of human
      immunodeficiency virus positive (HIV+) cases, i.e., including people who are
      either aware or unaware of their HIV infection in 2010, lead many to wonder why
      the increase in incidence has reached today's unprecedented level and escalated
      within such a short time. This, in spite of prevention campaigns in countries
      affected by HIV/acquired immune deficiency syndrome (AIDS) with their urgent
      messages aimed at preventing HIV transmission by promoting changes in
      individual's behavior. This article analyzes the background of the prevention
      strategies, in particular their political, social and legal concepts in terms of 
      human rights, and reveals traits of human behavior not considered thus far. A
      radical reappraisal is necessary, at social and legislative levels, as well as
      options additional to current concepts. When ethical issues come up, they become 
      blamed for outmoded moralistic positions. However, ignoring the reality has led
      to dire consequences from prioritizing individual human rights over society's
      collective need to prevent the spread of HIV.
FAU - Dennin, Reinhard H
AU  - Dennin RH
AD  - Institute of Medical Microbiology and Hygiene, University of Luebeck, Campus
      Luebeck, 160 Ratzeburger Allee, Luebeck D-23538, Germany.
      reinhard.dennin@uk-sh.de
FAU - Lafrenz, Michael
AU  - Lafrenz M
FAU - Sinn, Arndt
AU  - Sinn A
FAU - Li, Lan-juan
AU  - Li LJ
LA  - eng
PT  - Journal Article
PT  - Review
PL  - China
TA  - J Zhejiang Univ Sci B
JT  - Journal of Zhejiang University. Science. B
JID - 101236535
SB  - IM
MH  - Discrimination, Psychological
MH  - Ethics, Medical
MH  - HIV Infections/*prevention & control/psychology/transmission
MH  - Health Policy
MH  - *Human Rights/legislation & jurisprudence
MH  - Humans
MH  - Politics
MH  - Risk Reduction Behavior
PMC - PMC3134848
EDAT- 2011/07/05 06:00
MHDA- 2011/11/01 06:00
CRDT- 2011/07/05 06:00
PHST- 2011/07/05 06:00 [entrez]
PHST- 2011/07/05 06:00 [pubmed]
PHST- 2011/11/01 06:00 [medline]
AID - 10.1631/jzus.B1000434 [doi]
PST - ppublish
SO  - J Zhejiang Univ Sci B. 2011 Jul;12(7):591-610. doi: 10.1631/jzus.B1000434.


PMID- 21725377
OWN - NLM
STAT- MEDLINE
DCOM- 20110929
LR  - 20110704
IS  - 0807-7096 (Electronic)
IS  - 0029-2001 (Linking)
VI  - 131
IP  - 13-14
DP  - 2011 Jul 1
TI  - [Ethical assessment when introducing new treatment].
PG  - 1276
LID - 10.4045/tidsskr.11.0512 [doi]
FAU - Evensen, Stein A
AU  - Evensen SA
AD  - s.a.evensen@medisin.uio.no
LA  - nor
PT  - Editorial
TT  - Etikkvurdering ved innforing av ny behandling.
PL  - Norway
TA  - Tidsskr Nor Laegeforen
JT  - Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny
      raekke
JID - 0413423
SB  - IM
MH  - Clinical Trials as Topic/ethics
MH  - *Diffusion of Innovation
MH  - Documentation
MH  - *Ethics, Research
MH  - Heart Valve Prosthesis Implantation
MH  - Humans
MH  - Pulmonary Valve
EDAT- 2011/07/05 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/07/05 06:00
PHST- 2011/07/05 06:00 [entrez]
PHST- 2011/07/05 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - 2115234 [pii]
AID - 10.4045/tidsskr.11.0512 [doi]
PST - ppublish
SO  - Tidsskr Nor Laegeforen. 2011 Jul 1;131(13-14):1276. doi: 10.4045/tidsskr.11.0512.


PMID- 21725094
OWN - NLM
STAT- MEDLINE
DCOM- 20110907
LR  - 20211020
IS  - 1758-1095 (Electronic)
IS  - 0141-0768 (Linking)
VI  - 104
IP  - 7
DP  - 2011 Jul
TI  - Denial of pregnancy: a literature review and discussion of ethical and legal
      issues.
PG  - 286-91
LID - 10.1258/jrsm.2011.100376 [doi]
AB  - Denial of pregnancy is an important condition that is more common than expected, 
      with an incidence at 20 weeks gestation of approximately 1 in 475. The proportion
      of cases persisting until delivery is about 1 in 2500, a rate similar to that of 
      eclampsia. Denial of pregnancy poses adverse consequences including psychological
      distress, unassisted delivery and neonaticide. It is difficult to predict which
      women will develop denial of pregnancy. There are a number of forms of denial of 
      pregnancy, including psychotic and non-psychotic variants. Denial of pregnancy is
      a 'red flag' that should trigger referral for psychiatric assessment. A national 
      registry may help to provide more information about this condition and implement 
      appropriate care. This condition poses challenging legal and ethical issues
      including assessment of maternal capacity, evaluation of maternal (and possibly
      fetal) best interests and the possibility of detention in hospital.
FAU - Jenkins, Angela
AU  - Jenkins A
AD  - Department of Anaesthesia, Victoria Infirmary, Glasgow, UK.
      angelajenkins3@doctors.org.uk
FAU - Millar, Simon
AU  - Millar S
FAU - Robins, James
AU  - Robins J
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J R Soc Med
JT  - Journal of the Royal Society of Medicine
JID - 7802879
SB  - IM
MH  - *Denial, Psychological
MH  - Depersonalization/complications/psychology
MH  - Female
MH  - Humans
MH  - Maternal Behavior/*psychology
MH  - Mothers/*psychology
MH  - Pregnancy/psychology
MH  - Pregnancy Complications/*psychology
MH  - Pregnancy Trimesters/psychology
MH  - Prenatal Care/methods
MH  - Psychotic Disorders/complications/*psychology
MH  - Risk Factors
MH  - Women's Health
PMC - PMC3128877
EDAT- 2011/07/05 06:00
MHDA- 2011/09/08 06:00
CRDT- 2011/07/05 06:00
PHST- 2011/07/05 06:00 [entrez]
PHST- 2011/07/05 06:00 [pubmed]
PHST- 2011/09/08 06:00 [medline]
AID - 104/7/286 [pii]
AID - 10.1258/jrsm.2011.100376 [doi]
PST - ppublish
SO  - J R Soc Med. 2011 Jul;104(7):286-91. doi: 10.1258/jrsm.2011.100376.


PMID- 21725085
OWN - NLM
STAT- MEDLINE
DCOM- 20120301
LR  - 20120910
IS  - 1471-8391 (Electronic)
IS  - 0007-1420 (Linking)
VI  - 99
DP  - 2011
TI  - Food additives: an ethical evaluation.
PG  - 7-23
LID - 10.1093/bmb/ldr024 [doi]
AB  - BACKGROUND: Food additives are an integral part of the modern food system, but
      opinion polls showing most Europeans have worries about them imply an urgent need
      for ethical analysis of their use. SOURCES OF DATA: The existing literature on
      food ethics, safety assessment and animal testing. AREAS OF AGREEMENT: Food
      additives provide certain advantages in terms of many people's lifestyles. AREAS 
      OF CONTROVERSY: There are disagreements about the appropriate application of the 
      precautionary principle and of the value and ethical validity of animal tests in 
      assessing human safety. GROWING POINTS: Most consumers have a poor understanding 
      of the relative benefits and risks of additives, but concerns over food safety
      and animal testing remain high. AREAS TIMELY FOR DEVELOPING RESEARCH: Examining
      the impacts of food additives on consumer sovereignty, consumer health and on
      animals used in safety testing should allow a more informed debate about their
      appropriate uses.
FAU - Mepham, Ben
AU  - Mepham B
AD  - Centre for Applied Bioethics, School of Biosciences, University of Nottingham,
      Sutton Bonington Campus, Loughborough LE12 5RD, UK. ben.mepham@nottingham.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20110702
PL  - England
TA  - Br Med Bull
JT  - British medical bulletin
JID - 0376542
RN  - 0 (Food Additives)
SB  - IM
MH  - Animal Use Alternatives/ethics
MH  - Animals
MH  - *Consumer Product Safety/legislation & jurisprudence/standards
MH  - Ethical Analysis
MH  - *Food Additives/adverse effects/analysis
MH  - Food Inspection/*methods
MH  - Humans
MH  - Legislation, Food/*ethics
MH  - Public Opinion
MH  - Risk Assessment
EDAT- 2011/07/05 06:00
MHDA- 2012/03/02 06:00
CRDT- 2011/07/05 06:00
PHST- 2011/07/05 06:00 [entrez]
PHST- 2011/07/05 06:00 [pubmed]
PHST- 2012/03/02 06:00 [medline]
AID - ldr024 [pii]
AID - 10.1093/bmb/ldr024 [doi]
PST - ppublish
SO  - Br Med Bull. 2011;99:7-23. doi: 10.1093/bmb/ldr024. Epub 2011 Jul 2.


PMID- 21724900
OWN - NLM
STAT- MEDLINE
DCOM- 20120327
LR  - 20161020
IS  - 1526-3347 (Electronic)
IS  - 0191-9601 (Linking)
VI  - 32
IP  - 7
DP  - 2011 Jul
TI  - Ethics for the pediatrician: caring for abused children.
PG  - e73-8
LID - 10.1542/pir.32-7-e73 [doi]
FAU - Fisher, Marilyn A
AU  - Fisher MA
AD  - Albany Medical Center, NY, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pediatr Rev
JT  - Pediatrics in review
JID - 8103046
SB  - IM
MH  - Brain Death
MH  - Child
MH  - Child Abuse/*ethics/legislation & jurisprudence/mortality
MH  - Domestic Violence/ethics/legislation & jurisprudence/psychology
MH  - *Ethics, Medical
MH  - Foster Home Care/ethics
MH  - Humans
MH  - Life Support Care/ethics
MH  - Mandatory Reporting
MH  - Munchausen Syndrome by Proxy/diagnosis
MH  - Pediatrics/*ethics
MH  - Professional-Family Relations/ethics
EDAT- 2011/07/05 06:00
MHDA- 2012/03/28 06:00
CRDT- 2011/07/05 06:00
PHST- 2011/07/05 06:00 [entrez]
PHST- 2011/07/05 06:00 [pubmed]
PHST- 2012/03/28 06:00 [medline]
AID - 32/7/e73 [pii]
AID - 10.1542/pir.32-7-e73 [doi]
PST - ppublish
SO  - Pediatr Rev. 2011 Jul;32(7):e73-8. doi: 10.1542/pir.32-7-e73.


PMID- 21724078
OWN - NLM
STAT- MEDLINE
DCOM- 20110830
LR  - 20191210
IS  - 1097-6752 (Electronic)
IS  - 0889-5406 (Linking)
VI  - 140
IP  - 1
DP  - 2011 Jul
TI  - Ethics in orthodontics. Communication in the face of conflict.
PG  - 5
LID - 10.1016/j.ajodo.2011.03.014 [doi]
FAU - Greco, Peter M
AU  - Greco PM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Orthod Dentofacial Orthop
JT  - American journal of orthodontics and dentofacial orthopedics : official
      publication of the American Association of Orthodontists, its constituent
      societies, and the American Board of Orthodontics
JID - 8610224
SB  - IM
MH  - *Conflict, Psychological
MH  - Humans
MH  - Insurance, Liability
MH  - Medical Errors/*ethics
MH  - Truth Disclosure/*ethics
EDAT- 2011/07/05 06:00
MHDA- 2011/08/31 06:00
CRDT- 2011/07/05 06:00
PHST- 2011/03/01 00:00 [received]
PHST- 2011/03/01 00:00 [revised]
PHST- 2011/03/01 00:00 [accepted]
PHST- 2011/07/05 06:00 [entrez]
PHST- 2011/07/05 06:00 [pubmed]
PHST- 2011/08/31 06:00 [medline]
AID - S0889-5406(11)00337-4 [pii]
AID - 10.1016/j.ajodo.2011.03.014 [doi]
PST - ppublish
SO  - Am J Orthod Dentofacial Orthop. 2011 Jul;140(1):5. doi:
      10.1016/j.ajodo.2011.03.014.


PMID- 21723676
OWN - NLM
STAT- MEDLINE
DCOM- 20120430
LR  - 20140812
IS  - 1773-0430 (Electronic)
IS  - 0150-9918 (Linking)
VI  - 40
IP  - 6
DP  - 2011 Oct
TI  - [Fertility preservation in cancer women: a multidisciplinary approach].
PG  - 487-91
LID - 10.1016/j.jgyn.2011.05.006 [doi]
AB  - Over the past two decades, major advances in diagnostic modalities and treatment 
      have markedly improved rates of cure for adult cancers. As a consequence, the
      number of long-term survivors is increasing, and fertility preservation has
      become a major issue for young patient about to start treatment for cancer.
      Whether fertility preservation is a promising option, most of the technologies
      currently used are far from being well established or are even still
      experimental. Patients should be aware that no method guarantees success.
      Psychological and ethical impacts of fertility preservation are major concerns
      and should be included in the multidisciplinary approach of the patients.
CI  - Copyright (c) 2011 Elsevier Masson SAS. All rights reserved.
FAU - Treves, R
AU  - Treves R
AD  - Service de gynecologie-obstetrique et medecine de la reproduction, hopital
      Antoine-Beclere, AP-HP, 157, rue de Porte-de-Trivaux, 92141 Clamart, France.
FAU - Grynberg, M
AU  - Grynberg M
FAU - Hesters, L
AU  - Hesters L
FAU - Fanchin, R
AU  - Fanchin R
FAU - Frydman, R
AU  - Frydman R
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Preservation de la fertilite feminine en cas de cancer : interet d'une prise en
      charge pluridisciplinaire.
DEP - 20110701
PL  - France
TA  - J Gynecol Obstet Biol Reprod (Paris)
JT  - Journal de gynecologie, obstetrique et biologie de la reproduction
JID - 0322206
SB  - IM
MH  - Adult
MH  - Attitude to Death
MH  - Female
MH  - Fertility Preservation/*methods
MH  - Humans
MH  - Infertility, Female/prevention & control/psychology
MH  - *Interdisciplinary Communication
MH  - Neoplasms/psychology/rehabilitation/*therapy
MH  - Therapeutic Human Experimentation
MH  - Treatment Refusal/psychology
MH  - *Women
EDAT- 2011/07/05 06:00
MHDA- 2012/05/01 06:00
CRDT- 2011/07/05 06:00
PHST- 2011/01/15 00:00 [received]
PHST- 2011/04/25 00:00 [revised]
PHST- 2011/05/23 00:00 [accepted]
PHST- 2011/07/05 06:00 [entrez]
PHST- 2011/07/05 06:00 [pubmed]
PHST- 2012/05/01 06:00 [medline]
AID - S0368-2315(11)00156-6 [pii]
AID - 10.1016/j.jgyn.2011.05.006 [doi]
PST - ppublish
SO  - J Gynecol Obstet Biol Reprod (Paris). 2011 Oct;40(6):487-91. doi:
      10.1016/j.jgyn.2011.05.006. Epub 2011 Jul 1.


PMID- 21723352
OWN - NLM
STAT- MEDLINE
DCOM- 20120208
LR  - 20110815
IS  - 1873-2518 (Electronic)
IS  - 0264-410X (Linking)
VI  - 29
IP  - 37
DP  - 2011 Aug 26
TI  - Ethical issues in preventing mother-to-child transmission of hepatitis B by
      immunisation.
PG  - 6159-62
LID - 10.1016/j.vaccine.2011.06.065 [doi]
AB  - Without intervention, a pregnant woman who is a chronic hepatitis B carrier is at
      risk of transmitting hepatitis B and of her infant becoming a chronic carrier and
      having a significantly increased lifetime risk of developing liver cancer or
      cirrhosis. Hepatitis B vaccine and immunoglobulin reduce the risk of the baby
      becoming a carrier, but with only a short window period after birth to deliver
      this potentially life-saving intervention. We reviewed the evidence on the
      magnitude of the risk. If the carrier mother is e antigen positive (highly
      infective), the calculated risk to the infant without intervention is 75.2%,
      reduced to 6.0% by giving vaccine and immunoglobulin at birth. If the mother is
      surface antigen positive but e antigen negative, the risk to the infant without
      intervention is 10.3%, reduced to 1.0% by giving vaccine and immunoglobulin. If
      vaccine is accepted but immunoglobulin refused, as for example by some Jehovah's 
      Witnesses, the risk to babies of e antigen positive mothers is reduced to 21.0%
      and to babies of e antigen negative mothers to 2.6%. These figures can be used to
      inform parents and as a possible basis for child protection proceedings if
      parents decline vaccine and/or immunoglobulin. We argue from the perspective of
      the best interests of the child that the severity of the condition justifies
      initiating child protection proceedings whenever a baby is born to a hepatitis B 
      carrier mother and, despite concerted attempts to persuade them, the parents
      refuse vaccine and/or immunoglobulin.
CI  - Crown Copyright (c) 2011. Published by Elsevier Ltd. All rights reserved.
FAU - Isaacs, David
AU  - Isaacs D
AD  - Clinical Ethics Advisory Group, Children's Hospital at Westmead, Westmead, NSW,
      2145, Australia. davidi@chw.edu.au
FAU - Kilham, Henry A
AU  - Kilham HA
FAU - Alexander, Shirley
AU  - Alexander S
FAU - Wood, Nick
AU  - Wood N
FAU - Buckmaster, Adam
AU  - Buckmaster A
FAU - Royle, Jenny
AU  - Royle J
LA  - eng
PT  - Journal Article
DEP - 20110630
PL  - Netherlands
TA  - Vaccine
JT  - Vaccine
JID - 8406899
RN  - 0 (Hepatitis B Antibodies)
RN  - 0 (Hepatitis B Vaccines)
RN  - 0 (Hepatitis B e Antigens)
RN  - 0 (Immunoglobulins)
SB  - IM
MH  - Adult
MH  - Carrier State/immunology/transmission
MH  - Female
MH  - *Hepatitis B/immunology/prevention & control/transmission
MH  - Hepatitis B Antibodies/immunology
MH  - Hepatitis B Vaccines/*therapeutic use
MH  - Hepatitis B e Antigens/immunology
MH  - Humans
MH  - Immunization/legislation & jurisprudence
MH  - Immunoglobulins/therapeutic use
MH  - Infant, Newborn
MH  - *Infectious Disease Transmission, Vertical
MH  - Liver Cirrhosis/virology
MH  - Liver Neoplasms/virology
MH  - Mothers
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/immunology/prevention & control
MH  - Risk
MH  - Treatment Refusal/ethics/*legislation & jurisprudence
EDAT- 2011/07/05 06:00
MHDA- 2012/02/09 06:00
CRDT- 2011/07/05 06:00
PHST- 2010/12/23 00:00 [received]
PHST- 2011/04/10 00:00 [revised]
PHST- 2011/06/15 00:00 [accepted]
PHST- 2011/07/05 06:00 [entrez]
PHST- 2011/07/05 06:00 [pubmed]
PHST- 2012/02/09 06:00 [medline]
AID - S0264-410X(11)00929-7 [pii]
AID - 10.1016/j.vaccine.2011.06.065 [doi]
PST - ppublish
SO  - Vaccine. 2011 Aug 26;29(37):6159-62. doi: 10.1016/j.vaccine.2011.06.065. Epub
      2011 Jun 30.


PMID- 21723312
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20120508
IS  - 1096-0260 (Electronic)
IS  - 0091-7435 (Linking)
VI  - 53
IP  - 3
DP  - 2011 Sep
TI  - How do we achieve informed choice for women considering breast screening?
PG  - 144-6
LID - 10.1016/j.ypmed.2011.06.013 [doi]
AB  - OBJECTIVE: In current medical literature, mammography and other cancer screening 
      programs are subject to controversy because of debate about the magnitude and
      nature of the benefits and harms. This paper discusses the issues around informed
      choice for women considering breast screening. METHOD: We discuss qualitative and
      quantitative studies of women's attitudes to breast screening and informed
      choice. RESULTS: Women view breast screening as a way of avoiding potential
      regret, and reassurance from normal results is highly valued. Screening
      participants acknowledge anxiety about false positives but awareness regarding
      potential overdetection of indolent breast cancer is minimal, and research is
      needed to assess how better understanding of screening downsides may affect
      women's views. In any case, weighing up screening advantages and disadvantages is
      sensitive to personal preferences. CONCLUSIONS: Communicators have an ethical
      obligation to make balanced information available to women, which is flexible
      enough to respond to the level of detail and involvement desired by each
      individual. Many women want to know more and to participate more actively in
      screening decisions. Techniques have been developed to present balanced
      information and support individual decision making in ways that are accessible
      and empowering for the wider community. Evaluations of breast cancer screening
      must integrate clinical data with evidence on the perspectives of women
      themselves.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Hersch, Jolyn
AU  - Hersch J
AD  - Screening and Test Evaluation Program, Sydney School of Public Health, Edward
      Ford Bldg (A27), University of Sydney, NSW 2006, Australia.
      jolyn.hersch@sydney.edu.au
FAU - Jansen, Jesse
AU  - Jansen J
FAU - Irwig, Les
AU  - Irwig L
FAU - Barratt, Alexandra
AU  - Barratt A
FAU - Thornton, Hazel
AU  - Thornton H
FAU - Howard, Kirsten
AU  - Howard K
FAU - McCaffery, Kirsten
AU  - McCaffery K
LA  - eng
PT  - Journal Article
DEP - 20110624
PL  - United States
TA  - Prev Med
JT  - Preventive medicine
JID - 0322116
SB  - IM
CIN - Prev Med. 2011 Dec;53(6):437; author reply 438. PMID: 21803070
MH  - Breast Neoplasms/*diagnosis
MH  - Choice Behavior/*ethics
MH  - Decision Making
MH  - Early Detection of Cancer/*psychology
MH  - Female
MH  - Health Education
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Informed Consent/*psychology
MH  - Patient Education as Topic/ethics/*methods
MH  - Qualitative Research
MH  - Women's Health/*ethics
EDAT- 2011/07/05 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/07/05 06:00
PHST- 2011/04/07 00:00 [received]
PHST- 2011/06/16 00:00 [revised]
PHST- 2011/06/17 00:00 [accepted]
PHST- 2011/07/05 06:00 [entrez]
PHST- 2011/07/05 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - S0091-7435(11)00239-8 [pii]
AID - 10.1016/j.ypmed.2011.06.013 [doi]
PST - ppublish
SO  - Prev Med. 2011 Sep;53(3):144-6. doi: 10.1016/j.ypmed.2011.06.013. Epub 2011 Jun
      24.


PMID- 21722831
OWN - NLM
STAT- MEDLINE
DCOM- 20110906
LR  - 20121003
IS  - 1097-6809 (Electronic)
IS  - 0741-5214 (Linking)
VI  - 54
IP  - 1
DP  - 2011 Jul
TI  - Patient-originated futility insight: ethical right or ethical plight?
PG  - 237-9
LID - 10.1016/j.jvs.2011.05.004 [doi]
FAU - Jones, James W
AU  - Jones JW
AD  - The Center for Medical Ethics and Health Policy, Baylor College of Medicine,
      Houston, TX, USA. jwjones@bcm.tmc.edu
FAU - McCullough, Laurence B
AU  - McCullough LB
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Vasc Surg
JT  - Journal of vascular surgery
JID - 8407742
SB  - IM
MH  - Attitude of Health Personnel
MH  - *Consciousness
MH  - Endarterectomy, Carotid/*adverse effects
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - *Medical Futility/ethics
MH  - Patients/*psychology
MH  - Physician-Patient Relations
MH  - Prognosis
MH  - *Quality of Life
MH  - Recovery of Function
MH  - Respiration, Artificial
MH  - Stress, Psychological/prevention & control
MH  - Stroke/etiology/physiopathology/psychology/*therapy
MH  - *Treatment Refusal/ethics
EDAT- 2011/07/05 06:00
MHDA- 2011/09/07 06:00
CRDT- 2011/07/05 06:00
PHST- 2011/07/05 06:00 [entrez]
PHST- 2011/07/05 06:00 [pubmed]
PHST- 2011/09/07 06:00 [medline]
AID - S0741-5214(11)01070-6 [pii]
AID - 10.1016/j.jvs.2011.05.004 [doi]
PST - ppublish
SO  - J Vasc Surg. 2011 Jul;54(1):237-9. doi: 10.1016/j.jvs.2011.05.004.


PMID- 21722541
OWN - NLM
STAT- MEDLINE
DCOM- 20111122
LR  - 20110704
IS  - 1603-9629 (Electronic)
IS  - 0907-8916 (Linking)
VI  - 58
IP  - 7
DP  - 2011 Jul
TI  - Similar recovery rates of Fusobacterium necrophorum from recurrently infected and
      non-infected tonsils.
PG  - A4295
AB  - INTRODUCTION: Recent studies implicate the presence of Fusobacterium necrophorum 
      (FN) in recurrent tonsillitis (RT), acute tonsillitis and peritonsillar abscess. 
      The objective of the present study was to determine whether FN plays a role in RT
      by comparing bacteriologic results from patients suffering from RT, tonsillar
      hypertrophy and halitosis or persistent sore throat syndrome (PSTS). We analyzed 
      both tonsils to determine the degree of concordance. MATERIAL AND METHODS: A
      prospective study was conducted in 80 patients aged 8-30 years who were
      undergoing elective tonsillectomy. The patients were divided into four groups
      according to indication for surgery. Aerobic and anaerobic cultures from the
      tonsillar surface and core were analyzed. RESULTS: FN was detected less
      frequently in the tonsillar cores of RT patients (22%) than in those of patients 
      without RT (30%) (p=0.44). FN detection frequencies ranged between 20% and 35%
      across the four groups. Betahaemolytic streptococci groups A/C/G (BHS) were
      detected significantly (p=0.007) more often in the RT group than in the
      halitosis/PSTS group. CONCLUSION: A possible role of FN in RT was not
      substantiated. Our results indicate that FN is likely to be part of the normal
      flora. The tonsillar surface and core flora carry considerable interpersonal
      diversity, but is very similar bilaterally in each individual. Other factors seem
      to play a major role in the development of the represented tonsillar diseases.
      FUNDING: Not relevant. TRIAL REGISTRATION: The study was approved by The Research
      Ethics Committee of Aarhus County (no. 20050034).
FAU - Klug, Tejs Ehlers
AU  - Klug TE
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Aarhus University
      Hospital, Noerrebrogade 44, 8000 Aarhus C, Denmark. tejsehlersklug@hotmail.com
FAU - Henriksen, Jens-Jacob
AU  - Henriksen JJ
FAU - Fuursted, Kurt
AU  - Fuursted K
FAU - Ovesen, Therese
AU  - Ovesen T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Denmark
TA  - Dan Med Bull
JT  - Danish medical bulletin
JID - 0066040
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Female
MH  - Fusobacterium Infections/*pathology/surgery
MH  - Fusobacterium necrophorum/*isolation & purification/pathogenicity
MH  - Humans
MH  - Male
MH  - Palatine Tonsil/*microbiology
MH  - Prospective Studies
MH  - Recurrence
MH  - Statistics, Nonparametric
MH  - *Tonsillectomy
MH  - Tonsillitis/microbiology/*pathology/surgery
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2011/07/05 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/05 06:00
PHST- 2011/07/05 06:00 [entrez]
PHST- 2011/07/05 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - A4295 [pii]
PST - ppublish
SO  - Dan Med Bull. 2011 Jul;58(7):A4295.


PMID- 21722356
OWN - NLM
STAT- MEDLINE
DCOM- 20111031
LR  - 20211020
IS  - 1475-2875 (Electronic)
IS  - 1475-2875 (Linking)
VI  - 10
DP  - 2011 Jul 1
TI  - Optimal designs for population pharmacokinetic studies of oral artesunate in
      patients with uncomplicated falciparum malaria.
PG  - 181
LID - 10.1186/1475-2875-10-181 [doi]
AB  - BACKGROUND: Currently, population pharmacokinetic (PK) studies of anti-malarial
      drugs are designed primarily by the logistical and ethical constraints of taking 
      blood samples from patients, and the statistical models that are fitted to the
      data are not formally considered. This could lead to imprecise estimates of the
      target PK parameters, and/or designs insufficient to estimate all of the
      parameters. Optimal design methodology has been developed to determine blood
      sampling schedules that will yield precise parameter estimates within the
      practical constraints of sampling the study populations. In this work optimal
      design methods were used to determine sampling designs for typical future
      population PK studies of dihydroartemisinin, the principal biologically active
      metabolite of oral artesunate. METHODS: Optimal designs were derived using freely
      available software and were based on appropriate structural PK models from an
      analysis of data or the literature and key sampling constraints identified in a
      questionnaire sent to active malaria researchers (3-4 samples per patient, at
      least 15 minutes between samples). The derived optimal designs were then
      evaluated via simulation-estimation. RESULTS: The derived optimal sampling
      windows were 17 to 29 minutes, 30 to 57 minutes, 2.5 to 3.7 hours and 5.8 to 6.6 
      hours for non-pregnant adults; 16 to 29 minutes, 31 minutes to 1 hour, 2.0 to 3.4
      hours and 5.5 to 6.6 hours for designs with non-pregnant adults and children and 
      35 to 59 minutes, 1.2 to 3.4 hours, 3.4 to 4.9 hours and 6.0 to 8.0 hours for
      pregnant women. The optimal designs resulted in acceptable precision of the PK
      parameters. CONCLUSIONS: The proposed sampling designs in this paper are robust
      and efficient and should be considered in future PK studies of oral artesunate
      where only three or four blood samples can be collected.
FAU - Jamsen, Kris M
AU  - Jamsen KM
AD  - Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of
      Population Health, The University of Melbourne, Melbourne, Australia.
      kjamsen@pgrad.unimelb.edu.au
FAU - Duffull, Stephen B
AU  - Duffull SB
FAU - Tarning, Joel
AU  - Tarning J
FAU - Lindegardh, Niklas
AU  - Lindegardh N
FAU - White, Nicholas J
AU  - White NJ
FAU - Simpson, Julie A
AU  - Simpson JA
LA  - eng
GR  - 093956/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110701
PL  - England
TA  - Malar J
JT  - Malaria journal
JID - 101139802
RN  - 0 (Antimalarials)
RN  - 0 (Artemisinins)
RN  - 60W3249T9M (Artesunate)
SB  - IM
MH  - Administration, Oral
MH  - Adolescent
MH  - Adult
MH  - Antimalarials/*administration & dosage/*pharmacokinetics
MH  - Artemisinins/*administration & dosage/*pharmacokinetics
MH  - Artesunate
MH  - Child
MH  - Child, Preschool
MH  - Computer Simulation
MH  - Female
MH  - Humans
MH  - Infant
MH  - Malaria, Falciparum/*drug therapy
MH  - Models, Statistical
MH  - Pregnancy
MH  - Surveys and Questionnaires
MH  - Young Adult
PMC - PMC3155838
EDAT- 2011/07/05 06:00
MHDA- 2011/11/01 06:00
CRDT- 2011/07/05 06:00
PHST- 2011/05/02 00:00 [received]
PHST- 2011/07/01 00:00 [accepted]
PHST- 2011/07/05 06:00 [entrez]
PHST- 2011/07/05 06:00 [pubmed]
PHST- 2011/11/01 06:00 [medline]
AID - 1475-2875-10-181 [pii]
AID - 10.1186/1475-2875-10-181 [doi]
PST - epublish
SO  - Malar J. 2011 Jul 1;10:181. doi: 10.1186/1475-2875-10-181.


PMID- 21722323
OWN - NLM
STAT- MEDLINE
DCOM- 20130507
LR  - 20121120
IS  - 1748-3743 (Electronic)
IS  - 1748-3735 (Linking)
VI  - 7
IP  - 4
DP  - 2012 Dec
TI  - Bedrails and vulnerable older adults: how should nurses make 'safe and sound'
      decisions surrounding their use?
PG  - 272-81
LID - 10.1111/j.1748-3743.2011.00285.x [doi]
AB  - AIM AND OBJECTIVES: This paper examines the available evidence and uses ethical
      principles to answer how nurses should make safe and sound decisions surrounding 
      the use of bedrails. BACKGROUND: Bedrails are frequently observed in practice.
      They are designed as safety devices but there is evidence of indiscriminate and
      misuse with vulnerable adults. METHODS: The OVID MEDLINE, BNI and CINAHL
      databases were searched using key words dignity or autonomy and old[er] or
      elder[s/ly]), people, adult[s], patient[s], client[s] or user[s], and bed rails, 
      bed guards, cot sides or side rails (and associated variations). Additionally
      United Kingdom legislation, professional codes of practice and national patient
      safety agency resources were also searched. RESULTS: Bedrail use needs careful
      consideration. The published evidence can be confusing and contradictory. Nurses 
      have a duty to provide care which promotes respect for patient's autonomy,
      integrity and dignity for which individualised assessment is essential.
      Additionally overt consideration of beneficence, non-maleficence and justice
      supports decision making. CONCLUSIONS: Protection and promotion of respect for
      autonomy, integrity and dignity especially with older adults must be evidenced in
      practice. The use of an ethical framework can enable nurses to make transparent
      and defensible decisions about the appropriate use of bedrails, thereby
      fulfilling professional, moral, and legal requirements. IMPLICATIONS FOR
      PRACTICE: Bedrail use has implications beyond falls prevention. Protection and
      promotion of respect for autonomy, integrity and dignity with older adults must
      be considered in decision-making. Physical safety must be assessed as part of a
      holistic assessment. Nurses may need support and training to ensure 'safe and
      sound' surrogate decision-making in practice.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Shanahan, Denise J
AU  - Shanahan DJ
AD  - Cardiff and Vale University Health Board, Honorary Tutor Cardiff University,
      Cardiff, UK. Denise.Shanahan@wales.nhs.uk
LA  - eng
PT  - Journal Article
DEP - 20110704
PL  - England
TA  - Int J Older People Nurs
JT  - International journal of older people nursing
JID - 101267281
SB  - IM
MH  - Accidental Falls/*prevention & control/statistics & numerical data
MH  - Aged
MH  - Aged, 80 and over
MH  - Beds/*ethics
MH  - Decision Making/ethics
MH  - Geriatric Nursing/*ethics/methods
MH  - Humans
MH  - Personal Autonomy
MH  - Personhood
MH  - Restraint, Physical/*ethics/methods
MH  - Risk Assessment/ethics/methods
MH  - Risk Factors
MH  - Safety Management/*ethics/methods
MH  - Social Justice/ethics
MH  - Wounds and Injuries/epidemiology/nursing/*prevention & control
EDAT- 2011/07/05 06:00
MHDA- 2013/05/08 06:00
CRDT- 2011/07/05 06:00
PHST- 2011/07/05 06:00 [entrez]
PHST- 2011/07/05 06:00 [pubmed]
PHST- 2013/05/08 06:00 [medline]
AID - 10.1111/j.1748-3743.2011.00285.x [doi]
PST - ppublish
SO  - Int J Older People Nurs. 2012 Dec;7(4):272-81. doi:
      10.1111/j.1748-3743.2011.00285.x. Epub 2011 Jul 4.


PMID- 21721374
OWN - NLM
STAT- MEDLINE
DCOM- 20110804
LR  - 20191210
IS  - 1018-9068 (Print)
IS  - 1018-9068 (Linking)
VI  - 21
IP  - 4
DP  - 2011
TI  - Adaptation and validation of the Spanish version of the Quality Of Life in Latex 
      Allergy questionnaire (QOLLA).
PG  - 283-9
AB  - OBJECTIVE: The aim of the present study was to translate into Spanish and
      transculturally adapt the Quality of Life in Latex Allergy questionnaire (QOLLA) 
      in order to provide a validated instrument for use in research and daily
      practice. METHODS: Patients diagnosed with latex allergy were invited to
      participate in an observational prospective multicenter study to validate the
      Spanish version of the QOLLA following the recommendations of the World Health
      Organization. The study included 3 phases--feasibility, reliability, and
      cross-sectional validation-and was approved by the Ethics Committee of Hospital
      Ramon y Cajal. RESULTS: Mean time to complete the questionnaire was 4.7 minutes. 
      The maximum score was 28 (mean, 7.7; median, 4).The SF-12 score ranged from 25.8 
      to 51.6 in the physical domain and from 20.8 to 61.5 in the mental domain.
      Internal consistency was excellent (Cronbach alpha, 0.9348). The kappa index
      fluctuated between 0.40 and 0.93. A kappa of 0.84 was obtained for the global
      score in 5 categories. Sixty patients were included to evaluate construct
      validity. Mean age was 39 years and 49 patients were women (80%). The global
      score ranged between 0 and 30 (mean, 11.69; median, 11). Spearman correlation
      coefficients between the QOLLA and a visual analog scale and the SF-12 physical, 
      mental, and severity scales according to the researcher were--0.47, 0.37, 0.29,
      and 0.54, respectively. CONCLUSION: The QOLLA is a feasible, valid, and reliable 
      instrument for the measurement of disease-specific quality of life in adult
      patients diagnosed with latex allergy. It could play an important role in
      determining suitable treatment for latex-allergy.
FAU - Dieguez, M C
AU  - Dieguez MC
AD  - Seccion de Alergia, Servicio de Medicina Interna, Hospital del Sureste, Arganda
      del Rey, Spain.
FAU - Cerecedo, I
AU  - Cerecedo I
FAU - Muriel, A
AU  - Muriel A
FAU - Losada, A
AU  - Losada A
FAU - Garcia, E
AU  - Garcia E
FAU - Lazaro, M
AU  - Lazaro M
FAU - de la Hoz, B
AU  - de la Hoz B
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
PL  - Spain
TA  - J Investig Allergol Clin Immunol
JT  - Journal of investigational allergology & clinical immunology
JID - 9107858
SB  - IM
MH  - Adult
MH  - Cross-Sectional Studies
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Language
MH  - Latex Hypersensitivity/*psychology
MH  - Male
MH  - Middle Aged
MH  - *Quality of Life
MH  - Reproducibility of Results
MH  - Severity of Illness Index
MH  - Spain
MH  - *Surveys and Questionnaires
MH  - Young Adult
EDAT- 2011/07/05 06:00
MHDA- 2011/08/05 06:00
CRDT- 2011/07/05 06:00
PHST- 2011/07/05 06:00 [entrez]
PHST- 2011/07/05 06:00 [pubmed]
PHST- 2011/08/05 06:00 [medline]
PST - ppublish
SO  - J Investig Allergol Clin Immunol. 2011;21(4):283-9.


PMID- 21720737
OWN - NLM
STAT- MEDLINE
DCOM- 20120111
LR  - 20160512
IS  - 1618-2650 (Electronic)
IS  - 1618-2642 (Linking)
VI  - 401
IP  - 4
DP  - 2011 Sep
TI  - Simultaneous measurement of endogenous cortisol, cortisone,
      dehydroepiandrosterone, and dehydroepiandrosterone sulfate in nails by use of
      UPLC-MS-MS.
PG  - 1153-62
LID - 10.1007/s00216-011-5172-3 [doi]
AB  - Steroid hormone concentrations are mostly determined by using different body
      fluids as matrices and applying immunoassay techniques. However, usability of
      these approaches may be restricted for several reasons, including ethical
      barriers to invasive sampling. Therefore, we developed an ultra-performance
      LC-MS-MS method for high-throughput determination of concentrations of cortisol, 
      cortisone, dehydroepiandrosterone (DHEA), and DHEA sulfate (DHEAS) in small
      quantities of human nails. The method was validated for linearity, limits of
      detection and quantification, recovery, intra and interassay precision, accuracy,
      and matrix effect. Samples from 10 adult women were analyzed to provide
      proof-of-principle for the method's applicability. Calibration curves were linear
      (r(2) > 0.999) in the ranges 10-5000 pg mg(-1) for cortisol, cortisone, and
      DHEAS, and 50-5000 pg mg(-1) for DHEA. Limits of quantification were 10 pg mg(-1)
      for cortisol, cortisone, and DHEAS, and 50 pg mg(-1) for DHEA. The sensitivity
      and specificity of the method were good, and there was no interference with the
      analytes. Mean recovery of cortisol, cortisone, DHEA, and DHEAS was 90.5%, 94.1%,
      84.9%, and 95.9%, respectively, with good precision (coefficient of variation
      <14% for all analytes) and accuracy (relative error (%) -8.3% to 12.2% for all
      analytes). The median (pg mg(-1), range) hormone concentrations were 69.5
      (36-158), 65 (32-133), 212 (50-1077), and 246 (115-547) for cortisol, cortisone, 
      DHEA, and DHEAS, respectively. This method enables measurement of cortisol,
      cortisone, DHEA, and DHEAS in small quantities of human nails, leading to the
      development of applications in endocrinology and beyond.
FAU - Ben Khelil, Mehdi
AU  - Ben Khelil M
AD  - Institute of Legal Medicine, University of Strasbourg, Strasbourg, France.
FAU - Tegethoff, Marion
AU  - Tegethoff M
FAU - Meinlschmidt, Gunther
AU  - Meinlschmidt G
FAU - Jamey, Carole
AU  - Jamey C
FAU - Ludes, Bertrand
AU  - Ludes B
FAU - Raul, Jean-Sebastien
AU  - Raul JS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110701
PL  - Germany
TA  - Anal Bioanal Chem
JT  - Analytical and bioanalytical chemistry
JID - 101134327
RN  - 0 (Steroids)
RN  - 459AG36T1B (Dehydroepiandrosterone)
RN  - 57B09Q7FJR (Dehydroepiandrosterone Sulfate)
RN  - V27W9254FZ (Cortisone)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Chemistry Techniques, Analytical/*methods
MH  - *Chromatography, Liquid
MH  - Cortisone/*analysis
MH  - Dehydroepiandrosterone/*analysis
MH  - Dehydroepiandrosterone Sulfate/*analysis
MH  - Female
MH  - Humans
MH  - Hydrocortisone/*analysis
MH  - Limit of Detection
MH  - *Mass Spectrometry
MH  - Nails/*chemistry
MH  - Steroids/analysis
EDAT- 2011/07/02 06:00
MHDA- 2012/01/12 06:00
CRDT- 2011/07/02 06:00
PHST- 2011/04/08 00:00 [received]
PHST- 2011/06/08 00:00 [accepted]
PHST- 2011/06/02 00:00 [revised]
PHST- 2011/07/02 06:00 [entrez]
PHST- 2011/07/02 06:00 [pubmed]
PHST- 2012/01/12 06:00 [medline]
AID - 10.1007/s00216-011-5172-3 [doi]
PST - ppublish
SO  - Anal Bioanal Chem. 2011 Sep;401(4):1153-62. doi: 10.1007/s00216-011-5172-3. Epub 
      2011 Jul 1.


PMID- 21720152
OWN - NLM
STAT- MEDLINE
DCOM- 20120301
LR  - 20111109
IS  - 1662-8063 (Electronic)
IS  - 1662-4246 (Linking)
VI  - 15
IP  - 1
DP  - 2012
TI  - Ethical issues in recruiting prenatally diagnosed adults for research:
      Klinefelter syndrome as an example.
PG  - 31-3
LID - 10.1159/000328845 [doi]
FAU - Herlihy, A S
AU  - Herlihy AS
AD  - Murdoch Childrens Research Institute, The University of Melbourne, Parkville,
      Vic., Australia. amy.herlihy@mcri.edu.au
FAU - Halliday, J L
AU  - Halliday JL
FAU - Gillam, L H
AU  - Gillam LH
LA  - eng
PT  - Journal Article
DEP - 20110630
PL  - Switzerland
TA  - Public Health Genomics
JT  - Public health genomics
JID - 101474167
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biomedical Research/*ethics
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Klinefelter Syndrome/*diagnosis/*genetics
MH  - Patient Selection/*ethics
MH  - Pregnancy
MH  - *Prenatal Diagnosis
MH  - Young Adult
EDAT- 2011/07/02 06:00
MHDA- 2012/03/02 06:00
CRDT- 2011/07/02 06:00
PHST- 2010/12/09 00:00 [received]
PHST- 2011/04/18 00:00 [accepted]
PHST- 2011/07/02 06:00 [entrez]
PHST- 2011/07/02 06:00 [pubmed]
PHST- 2012/03/02 06:00 [medline]
AID - 000328845 [pii]
AID - 10.1159/000328845 [doi]
PST - ppublish
SO  - Public Health Genomics. 2012;15(1):31-3. doi: 10.1159/000328845. Epub 2011 Jun
      30.


PMID- 21720079
OWN - NLM
STAT- MEDLINE
DCOM- 20111121
LR  - 20190911
IS  - 1881-4883 (Electronic)
IS  - 0369-4305 (Linking)
VI  - 67
IP  - 6
DP  - 2011
TI  - [Research ethics and radiological protection: reflecting the discussion at the
      Japanese Society of Radiological Technology meeting].
PG  - 683-90
FAU - Kurihara, Chieko
AU  - Kurihara C
AD  - National Institute of Radiological Sciences Molecular Imaging Center.
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Nihon Hoshasen Gijutsu Gakkai Zasshi
JT  - Nihon Hoshasen Gijutsu Gakkai zasshi
JID - 7505722
SB  - IM
MH  - *Ethics, Research
MH  - Japan
MH  - Practice Guidelines as Topic
MH  - *Radiation Protection
MH  - Societies, Scientific
MH  - Technology, Radiologic
MH  - United States
EDAT- 2011/07/02 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/02 06:00
PHST- 2011/07/02 06:00 [entrez]
PHST- 2011/07/02 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - JST.JSTAGE/jjrt/67.683 [pii]
AID - 10.6009/jjrt.67.683 [doi]
PST - ppublish
SO  - Nihon Hoshasen Gijutsu Gakkai Zasshi. 2011;67(6):683-90. doi:
      10.6009/jjrt.67.683.


PMID- 21719871
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20161020
IS  - 1527-330X (Electronic)
IS  - 1090-820X (Linking)
VI  - 31
IP  - 5
DP  - 2011 Jul
TI  - Disclosing conflicts of interest to maintain ethical integrity.
PG  - 591-3
LID - 10.1177/1090820X11412525 [doi]
FAU - Nahai, Foad
AU  - Nahai F
LA  - eng
PT  - Editorial
PL  - England
TA  - Aesthet Surg J
JT  - Aesthetic surgery journal
JID - 9707469
SB  - IM
MH  - Authorship/standards
MH  - *Conflict of Interest
MH  - *Disclosure
MH  - Humans
MH  - Periodicals as Topic/*ethics
MH  - Publishing/ethics
EDAT- 2011/07/02 06:00
MHDA- 2011/11/09 06:00
CRDT- 2011/07/02 06:00
PHST- 2011/07/02 06:00 [entrez]
PHST- 2011/07/02 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - 31/5/591 [pii]
AID - 10.1177/1090820X11412525 [doi]
PST - ppublish
SO  - Aesthet Surg J. 2011 Jul;31(5):591-3. doi: 10.1177/1090820X11412525.


PMID- 21719620
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20211020
IS  - 1942-5546 (Electronic)
IS  - 0025-6196 (Linking)
VI  - 86
IP  - 7
DP  - 2011 Jul
TI  - The science and ethics of induced pluripotency: what will become of embryonic
      stem cells?
PG  - 634-40
LID - 10.4065/mcp.2011.0054 [doi]
AB  - For over a decade, the field of stem cell research has advanced tremendously and 
      gained new attention in light of novel insights and emerging developments for
      regenerative medicine. Invariably, multiple considerations come into play, and
      clinicians and researchers must weigh the benefits of certain stem cell platforms
      against the costs they incur. Notably, human embryonic stem (hES) cell research
      has been a source of continued debate, leading to differing policies and
      regulations worldwide. This article briefly reviews current stem cell platforms, 
      looking specifically at the two existing pluripotent lines available for
      potential therapeutic applications: hES cells and induced pluripotent stem (iPS) 
      cells. We submit iPS technology as a viable and possibly superior alternative for
      future medical and research endeavors as it obviates many ethical and
      resource-related concerns posed by hES cells while prospectively matching their
      potential for scientific use. However, while the clinical realities of iPS cells 
      appear promising, we must recognize the current limitations of this technology,
      avoid hype, and articulate ethically acceptable medical and scientific goals.
FAU - Zacharias, David G
AU  - Zacharias DG
AD  - Mayo Medical School, Mayo Clinic, Rochester, MN 55905, USA.
FAU - Nelson, Timothy J
AU  - Nelson TJ
FAU - Mueller, Paul S
AU  - Mueller PS
FAU - Hook, C Christopher
AU  - Hook CC
LA  - eng
GR  - DP2 OD007015/OD/NIH HHS/United States
GR  - 1DP2OD007015/OD/NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Mayo Clin Proc
JT  - Mayo Clinic proceedings
JID - 0405543
SB  - IM
CIN - Mayo Clin Proc. 2011 Jul;86(7):600-2. PMID: 21719616
MH  - *Embryonic Stem Cells
MH  - Humans
MH  - *Pluripotent Stem Cells
MH  - Regenerative Medicine/*ethics/legislation & jurisprudence
PMC - PMC3127559
EDAT- 2011/07/02 06:00
MHDA- 2011/10/25 06:00
CRDT- 2011/07/02 06:00
PHST- 2011/07/02 06:00 [entrez]
PHST- 2011/07/02 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
AID - S0025-6196(11)60069-4 [pii]
AID - 10.4065/mcp.2011.0054 [doi]
PST - ppublish
SO  - Mayo Clin Proc. 2011 Jul;86(7):634-40. doi: 10.4065/mcp.2011.0054.


PMID- 21718961
OWN - NLM
STAT- MEDLINE
DCOM- 20120413
LR  - 20120124
IS  - 1879-1883 (Electronic)
IS  - 0002-9610 (Linking)
VI  - 203
IP  - 2
DP  - 2012 Feb
TI  - The formal and informal surgical ethics curriculum: views of resident and staff
      surgeons in Toronto.
PG  - 258-65
LID - 10.1016/j.amjsurg.2011.02.008 [doi]
AB  - BACKGROUND: Understanding what staff surgeons think surgical trainees should
      learn and the ethical issues that trainees need to manage can strengthen surgical
      ethics education. METHODS: Participants were recruited from the 15 surgical
      specialty and subspecialty programs at the University of Toronto. Semistructured 
      interviews and focus groups were conducted with 13 ethics coordinators from the
      surgical staff and 64 resident trainees. Data were analyzed qualitatively using
      modified thematic analysis. RESULTS: All coordinators and trainees felt that
      ethics education was an important component of surgical training. Real cases,
      varying teaching methods, and teachers with applicable clinical experience were
      valued. Trainees identified intraprofessional and interprofessional conflict,
      staff behavior perceived to be unethical, and their own lack of experience as
      challenging issues rarely addressed in the formal ethics curriculum. CONCLUSIONS:
      Ethics education is highly valued by trainees and teachers. Some ethical issues
      important to trainees are underrepresented in the formal curriculum. Staff
      surgeons and senior residents are practicing ethicists and role models whose
      impact on the moral development of residents is profound. Their participation in 
      the formal curriculum helps less experienced junior residents realize its value.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Howard, Frazer
AU  - Howard F
AD  - Joint Centre for Bioethics, University of Toronto, ON, Canada.
FAU - McKneally, Martin F
AU  - McKneally MF
FAU - Upshur, Ross E G
AU  - Upshur RE
FAU - Levin, Alex V
AU  - Levin AV
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110629
PL  - United States
TA  - Am J Surg
JT  - American journal of surgery
JID - 0370473
SB  - IM
MH  - *Attitude of Health Personnel
MH  - *Curriculum
MH  - Ethics, Medical/*education
MH  - Female
MH  - Focus Groups
MH  - Humans
MH  - *Internship and Residency
MH  - Male
MH  - Ontario
MH  - Specialties, Surgical/*education/ethics
EDAT- 2011/07/02 06:00
MHDA- 2012/04/14 06:00
CRDT- 2011/07/02 06:00
PHST- 2010/11/20 00:00 [received]
PHST- 2011/02/18 00:00 [revised]
PHST- 2011/02/18 00:00 [accepted]
PHST- 2011/07/02 06:00 [entrez]
PHST- 2011/07/02 06:00 [pubmed]
PHST- 2012/04/14 06:00 [medline]
AID - S0002-9610(11)00258-3 [pii]
AID - 10.1016/j.amjsurg.2011.02.008 [doi]
PST - ppublish
SO  - Am J Surg. 2012 Feb;203(2):258-65. doi: 10.1016/j.amjsurg.2011.02.008. Epub 2011 
      Jun 29.


PMID- 21718746
OWN - NLM
STAT- MEDLINE
DCOM- 20111209
LR  - 20220309
IS  - 1873-2518 (Electronic)
IS  - 0264-410X (Linking)
VI  - 29
IP  - 35
DP  - 2011 Aug 11
TI  - Of mice and not humans: how reliable are animal models for evaluation of herpes
      CD8(+)-T cell-epitopes-based immunotherapeutic vaccine candidates?
PG  - 5824-36
LID - 10.1016/j.vaccine.2011.06.083 [doi]
AB  - Herpes simplex virus type 1 and type 2 (HSV-1 and HSV-2)-specific CD8(+) T cells 
      that reside in sensory ganglia, appear to control recurrent herpetic disease by
      aborting or reducing spontaneous and sporadic reactivations of latent virus. A
      reliable animal model is the ultimate key factor to test the efficacy of
      therapeutic vaccines that boost the level and the quality of sensory
      ganglia-resident CD8(+) T cells against spontaneous herpes reactivation from
      sensory neurons, yet its relevance has been often overlooked. Herpes
      vaccinologists are hesitant about using mouse as a model in pre-clinical
      development of therapeutic vaccines because they do not adequately mimic
      spontaneous viral shedding or recurrent symptomatic diseases, as occurs in human.
      Alternatives to mouse models are rabbits and guinea pigs in which reactivation
      arise spontaneously with clinical herpetic features relevant to human disease.
      However, while rabbits and guinea pigs develop spontaneous HSV reactivation and
      recurrent ocular and genital disease none of them can mount CD8(+) T cell
      responses specific to Human Leukocyte Antigen- (HLA-)restricted epitopes. In this
      review, we discuss the advantages and limitations of these animal models and
      describe a novel "humanized" HLA transgenic rabbit, which shows spontaneous HSV-1
      reactivation, recurrent ocular disease and mounts CD8(+) T cell responses to
      HLA-restricted epitopes. Adequate investments are needed to develop reliable
      preclinical animal models, such as HLA class I and class II double transgenic
      rabbits and guinea pigs to balance the ethical and financial concerns associated 
      with the rising number of unsuccessful clinical trials for therapeutic vaccine
      formulations tested in unreliable mouse models.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Dasgupta, Gargi
AU  - Dasgupta G
AD  - Laboratory of Cellular and Molecular Immunology, The Gavin Herbert Eye Institute,
      University of California Irvine, School of Medicine, Irvine, CA 92697-4390, USA.
FAU - BenMohamed, Lbachir
AU  - BenMohamed L
LA  - eng
GR  - R01 EY014900-06A2/EY/NEI NIH HHS/United States
GR  - R01 EY019896-01A1/EY/NEI NIH HHS/United States
GR  - R01 EY019896/EY/NEI NIH HHS/United States
GR  - R03 EY014017-04/EY/NEI NIH HHS/United States
GR  - R03 EY014017/EY/NEI NIH HHS/United States
GR  - R01 EY019896-02/EY/NEI NIH HHS/United States
GR  - R01 EY014900/EY/NEI NIH HHS/United States
GR  - R01 EY14900/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110628
PL  - Netherlands
TA  - Vaccine
JT  - Vaccine
JID - 8406899
RN  - 0 (Epitopes, T-Lymphocyte)
RN  - 0 (HLA Antigens)
RN  - 0 (Herpes Simplex Virus Vaccines)
SB  - IM
MH  - Animals
MH  - Animals, Genetically Modified
MH  - CD8-Positive T-Lymphocytes/*immunology
MH  - *Disease Models, Animal
MH  - Epitopes, T-Lymphocyte/*immunology
MH  - Guinea Pigs
MH  - HLA Antigens/genetics
MH  - Herpes Genitalis/immunology/*prevention & control
MH  - Herpes Simplex Virus Vaccines/*immunology/therapeutic use
MH  - Herpesvirus 1, Human/immunology
MH  - Herpesvirus 2, Human/immunology
MH  - Humans
MH  - Immunization
MH  - Keratitis, Herpetic/immunology/*prevention & control/virology
MH  - Mice
MH  - Rabbits
PMC - PMC3159167
MID - NIHMS311474
EDAT- 2011/07/02 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/07/02 06:00
PHST- 2011/04/01 00:00 [received]
PHST- 2011/06/09 00:00 [revised]
PHST- 2011/06/14 00:00 [accepted]
PHST- 2011/07/02 06:00 [entrez]
PHST- 2011/07/02 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - S0264-410X(11)00957-1 [pii]
AID - 10.1016/j.vaccine.2011.06.083 [doi]
PST - ppublish
SO  - Vaccine. 2011 Aug 11;29(35):5824-36. doi: 10.1016/j.vaccine.2011.06.083. Epub
      2011 Jun 28.


PMID- 21718108
OWN - NLM
STAT- MEDLINE
DCOM- 20111205
LR  - 20181201
IS  - 2152-4998 (Electronic)
IS  - 2152-4971 (Linking)
VI  - 13
IP  - 4
DP  - 2011 Aug
TI  - Utilization of human amniotic mesenchymal cells as feeder layers to sustain
      propagation of human embryonic stem cells in the undifferentiated state.
PG  - 281-8
LID - 10.1089/cell.2010.0103 [doi]
AB  - Human embryonic stem (ES) cells are usually maintained in the undifferentiated
      state by culturing on feeder cells layers of mouse embryonic fibroblasts (MEFs). 
      However, MEFs are not suitable to support human ES cells used for clinical
      purpose because of risk of zoonosis from animal cells. Therefore, human
      tissue-based feeder layers need to be developed for human ES cells for clinical
      purpose. Hereof we report that human amniotic mesenchymal cells (hAMCs) could act
      as feeder cells for human ES cells, because they are easily obtained and
      relatively exempt from ethical problem. Like MEFs, hAMCs could act as feeder
      cells for human ES cells to grow well on. The self-renewal rate of human ES cells
      cultured on hAMCs feeders was higher than that on MEFs and human amniotic
      epithelial cells determined by measurement of colonial diameters and growth curve
      as well as cell cycle analysis. Both immunofluorescence staining and
      immunoblotting showed that human ES cells cultured on hAMCs expressed stem cell
      markers such as Oct-3/4, Sox2, and NANOG. Verified by embryoid body formation in 
      vitro and teratoma formation in vivo, we found out that after 20 passages of
      culture, human ES cells grown on hAMCs feeders could still retain the potency of 
      differentiating into three germ layers. Taken together, our data suggested hAMCs 
      may be safe feeder cells to sustain the propagation of human ES cells in
      undifferentiated state for future therapeutic use.
FAU - Zhang, Kehua
AU  - Zhang K
AD  - Department of Immunology, Institute of Clinical Medicine, China-Japan Friendship 
      Hospital, Beijing, People's Republic of China.
FAU - Cai, Zhe
AU  - Cai Z
FAU - Li, Yang
AU  - Li Y
FAU - Shu, Jun
AU  - Shu J
FAU - Pan, Lin
AU  - Pan L
FAU - Wan, Fang
AU  - Wan F
FAU - Li, Hong
AU  - Li H
FAU - Huang, Xiaojie
AU  - Huang X
FAU - He, Chun
AU  - He C
FAU - Liu, Yanqiu
AU  - Liu Y
FAU - Cui, Xiaohui
AU  - Cui X
FAU - Xu, Yang
AU  - Xu Y
FAU - Gao, Yan
AU  - Gao Y
FAU - Wu, Liqun
AU  - Wu L
FAU - Cao, Shanxia
AU  - Cao S
FAU - Li, Lingsong
AU  - Li L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110630
PL  - United States
TA  - Cell Reprogram
JT  - Cellular reprogramming
JID - 101528176
SB  - IM
MH  - Amnion/*cytology
MH  - Animals
MH  - Cell Differentiation/*physiology
MH  - Cells, Cultured
MH  - *Coculture Techniques
MH  - Embryonic Stem Cells/*cytology/physiology
MH  - Feeder Cells/*cytology
MH  - Fibroblasts/cytology/physiology
MH  - Humans
MH  - Mesenchymal Stem Cells/*cytology/physiology
MH  - Mice
MH  - Teratoma/pathology
EDAT- 2011/07/02 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/02 06:00
PHST- 2011/07/02 06:00 [entrez]
PHST- 2011/07/02 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1089/cell.2010.0103 [doi]
PST - ppublish
SO  - Cell Reprogram. 2011 Aug;13(4):281-8. doi: 10.1089/cell.2010.0103. Epub 2011 Jun 
      30.


PMID- 21717942
OWN - NLM
STAT- MEDLINE
DCOM- 20110809
LR  - 20110701
IS  - 0019-3062 (Print)
IS  - 0019-3062 (Linking)
VI  - 58
IP  - 3
DP  - 2011 Apr-May
TI  - National Student Nurses' Association, Inc. Code of Ethics: part II code of
      academic and clinical conduct and interpretive statements.
PG  - 42-7
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Imprint
JT  - Imprint
JID - 0163356
MH  - *Codes of Ethics
MH  - Humans
MH  - Societies, Nursing
MH  - *Students, Nursing
MH  - United States
EDAT- 2011/07/02 06:00
MHDA- 2011/08/10 06:00
CRDT- 2011/07/02 06:00
PHST- 2011/07/02 06:00 [entrez]
PHST- 2011/07/02 06:00 [pubmed]
PHST- 2011/08/10 06:00 [medline]
PST - ppublish
SO  - Imprint. 2011 Apr-May;58(3):42-7.


PMID- 21717924
OWN - NLM
STAT- MEDLINE
DCOM- 20110809
LR  - 20110701
IS  - 1060-135X (Print)
IS  - 1060-135X (Linking)
VI  - 36
IP  - 2
DP  - 2011 Apr-Jun
TI  - Don't be a Nellie: set your own work ethic high!
PG  - 4
FAU - Smith, Sarah C
AU  - Smith SC
AD  - Department of Ophthalmology, University of Iowa, Iowa City, IA 52242-1091, USA.
      sarah-smith@uiowa.edu
LA  - eng
PT  - Journal Article
PT  - Video-Audio Media
PL  - United States
TA  - Insight
JT  - Insight (American Society of Ophthalmic Registered Nurses)
JID - 9111431
MH  - *Career Choice
MH  - Delivery of Health Care/ethics/*standards
MH  - Humans
MH  - Male
MH  - Patient Care Team/*ethics
EDAT- 2011/07/02 06:00
MHDA- 2011/08/10 06:00
CRDT- 2011/07/02 06:00
PHST- 2011/07/02 06:00 [entrez]
PHST- 2011/07/02 06:00 [pubmed]
PHST- 2011/08/10 06:00 [medline]
PST - ppublish
SO  - Insight. 2011 Apr-Jun;36(2):4.


PMID- 21717666
OWN - NLM
STAT- MEDLINE
DCOM- 20110809
LR  - 20211020
IS  - 0008-4263 (Print)
IS  - 0008-4263 (Linking)
VI  - 102
IP  - 3
DP  - 2011 May-Jun
TI  - [Humanitarian ethics and the concept of justice].
PG  - 210-4
AB  - The bases of humanitarian assistance, beyond a legal norm--which appears to be
      essential given the inalienable obligations that result for all participating
      bodies--are influenced by philosophical and political conceptualizations framed
      in an ethics of justice. Actors in the humanitarian field who adhere to the
      Rawlsian social contract model their actions based on a philosophy that
      assistance is a noble and desirable option that remains in the hands of those who
      offer aid, and who can freely choose to not offer such assistance. Peter Singer
      and Thomas Pogge propose nuances to the understanding of the duty of assistance. 
      Not assisting would be bad, basically tantamount to killing. Assistance is no
      longer a caring act deserving of praise, but rather a moral obligation. The
      financial imperatives of associations, the growing complexity of activities and
      the development of an important element of communication lead to a
      professionalization of humanitarian medicine. A modern vision of humanitarian
      assistance requires an understanding of justice and solidarity and global
      outreach. We believe that ethics need to be embedded firmly in humanitarian
      actions that have clear political implications.
FAU - Quadrelli, Silvia
AU  - Quadrelli S
AD  - Instituto de Investigaciones Medicas Alfredo Lanari, Universidad de Buenos Aires,
      Buenos Aires, Argentine.
FAU - Colt, Henri
AU  - Colt H
FAU - Garcia, Camilo
AU  - Garcia C
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - L'ethique humanitaire et la notion de justice.
PL  - Switzerland
TA  - Can J Public Health
JT  - Canadian journal of public health = Revue canadienne de sante publique
JID - 0372714
SB  - IM
MH  - Humans
MH  - *International Cooperation
MH  - Relief Work/*ethics
MH  - *Social Justice
PMC - PMC6973606
EDAT- 2011/07/02 06:00
MHDA- 2011/08/10 06:00
CRDT- 2011/07/02 06:00
PHST- 2011/07/02 06:00 [entrez]
PHST- 2011/07/02 06:00 [pubmed]
PHST- 2011/08/10 06:00 [medline]
PST - ppublish
SO  - Can J Public Health. 2011 May-Jun;102(3):210-4.


PMID- 21716804
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 0976-3155 (Electronic)
IS  - 0976-3155 (Linking)
VI  - 2
IP  - 1
DP  - 2011 Jan
TI  - Placebo - More hatred than love.
PG  - 105-7
LID - 10.4103/0976-3147.80089 [doi]
AB  - A placebo is a sham medical intervention that can produce a placebo effect.
      Laboratory evidence supports the existence of several mechanisms of placebo
      effects in both healthy population and patients with a variety of medical
      conditions. The ethics of placebos have long been debated. However, accumulating 
      ethical concern has arisen from the worldwide use of placebo in randomized
      control trials (RCTs), which may render their participants without early and
      optimal treatment. Although the pilgrimage of placebo is still on the way,
      refinement of controls in RCTs is worth paying new attention to.
FAU - Zhang, Hong-Liang
AU  - Zhang HL
AD  - Department of Neurology, The First Hospital of Jilin University, Changchun,
      China. Department of Neurobiology, Care Sciences and Society, Karolinska
      Institute, Stockholm, Sweden.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Neurosci Rural Pract
JT  - Journal of neurosciences in rural practice
JID - 101533710
PMC - PMC3122983
OTO - NOTNLM
OT  - Ethics
OT  - placebo
OT  - randomized control trials
EDAT- 2011/07/01 06:00
MHDA- 2011/07/01 06:01
CRDT- 2011/07/01 06:00
PHST- 2011/07/01 06:00 [entrez]
PHST- 2011/07/01 06:00 [pubmed]
PHST- 2011/07/01 06:01 [medline]
AID - 10.4103/0976-3147.80089 [doi]
AID - JNRP-2-105 [pii]
PST - ppublish
SO  - J Neurosci Rural Pract. 2011 Jan;2(1):105-7. doi: 10.4103/0976-3147.80089.


PMID- 21716711
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20220311
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2011
DP  - 2011
TI  - Practices in wound healing studies of plants.
PG  - 438056
LID - 10.1155/2011/438056 [doi]
AB  - Wounds are the result of injuries to the skin that disrupt the other soft tissue.
      Healing of a wound is a complex and protracted process of tissue repair and
      remodeling in response to injury. Various plant products have been used in
      treatment of wounds over the years. Wound healing herbal extracts promote blood
      clotting, fight infection, and accelerate the healing of wounds.
      Phytoconstituents derived from plants need to be identified and screened for
      antimicrobial activity for management of wounds. The in vitro assays are useful, 
      quick, and relatively inexpensive. Small animals provide a multitude of model
      choices for various human wound conditions. The study must be conducted after
      obtaining approval of the Ethics Committee and according to the guidelines for
      care and use of animals. The prepared formulations of herbal extract can be
      evaluated by various physicopharmaceutical parameters. The wound healing
      efficacies of various herbal extracts have been evaluated in excision, incision, 
      dead space, and burn wound models. In vitro and in vivo assays are stepping
      stones to well-controlled clinical trials of herbal extracts.
FAU - Thakur, Rupesh
AU  - Thakur R
AD  - Biochemical Research Laboratory, Centre for Scientific Research and Development, 
      People's Group, Bhopal, Madhya Pradesh 462037, India.
FAU - Jain, Nitika
AU  - Jain N
FAU - Pathak, Raghvendra
AU  - Pathak R
FAU - Sandhu, Sardul Singh
AU  - Sandhu SS
LA  - eng
PT  - Journal Article
DEP - 20110526
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC3118986
EDAT- 2011/07/01 06:00
MHDA- 2011/07/01 06:01
CRDT- 2011/07/01 06:00
PHST- 2010/08/05 00:00 [received]
PHST- 2011/01/21 00:00 [revised]
PHST- 2011/02/24 00:00 [accepted]
PHST- 2011/07/01 06:00 [entrez]
PHST- 2011/07/01 06:00 [pubmed]
PHST- 2011/07/01 06:01 [medline]
AID - 10.1155/2011/438056 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2011;2011:438056. doi: 10.1155/2011/438056.
      Epub 2011 May 26.


PMID- 21715992
OWN - NLM
STAT- MEDLINE
DCOM- 20110901
LR  - 20220409
IS  - 1938-808X (Electronic)
IS  - 1040-2446 (Linking)
VI  - 86
IP  - 7
DP  - 2011 Jul
TI  - Commentary: medical student distress: a call to action.
PG  - 801-3
LID - 10.1097/ACM.0b013e31821da481 [doi]
AB  - Studies have found a high prevalence of psychological distress among medical
      students both in the United States and abroad. Distress among medical students
      has serious professional ramifications, including damaging effects on empathy,
      ethical conduct, and professionalism, as well as personal consequences such as
      substance abuse, broken relationships, and suicidal ideation. Given the effect of
      physician distress on quality of care, self-care (including personal appraisal of
      well-being, wellness promotion, and recognition of when help is needed) should be
      recognized as a core competency for physicians. In this issue of Academic
      Medicine, investigators at the Northwestern University Feinberg School of
      Medicine explore the benefits of teaching students to employ a cognitive
      behavioral approach to improving self-care. Beyond its demonstrated short-term
      efficacy, the approach they propose also has potential to help students develop
      the skills necessary to assess and promote resilience throughout their careers.
      Medical schools' responsibility to promote student wellness, however, goes beyond
      teaching students self-care skills and includes establishing an appropriate
      organizational culture and learning environment to promote student health.
      Achieving competency in self-care is a shared responsibility of the individual
      physician/resident/medical student and the organizational environment in which he
      or she functions.
FAU - Dyrbye, Liselotte N
AU  - Dyrbye LN
FAU - Shanafelt, Tait D
AU  - Shanafelt TD
LA  - eng
PT  - Editorial
PT  - Comment
PL  - United States
TA  - Acad Med
JT  - Academic medicine : journal of the Association of American Medical Colleges
JID - 8904605
SB  - IM
CON - Acad Med. 2011 Jul;86(7):901-6. PMID: 21617509
MH  - Cognitive Behavioral Therapy/methods
MH  - Education, Medical, Undergraduate/methods
MH  - Health Behavior
MH  - Health Promotion
MH  - Humans
MH  - Schools, Medical
MH  - Self Care/*methods/*psychology
MH  - Stress, Psychological/*etiology/*therapy
MH  - Students, Medical/*psychology
EDAT- 2011/07/01 06:00
MHDA- 2011/09/02 06:00
CRDT- 2011/07/01 06:00
PHST- 2011/07/01 06:00 [entrez]
PHST- 2011/07/01 06:00 [pubmed]
PHST- 2011/09/02 06:00 [medline]
AID - 10.1097/ACM.0b013e31821da481 [doi]
AID - 00001888-201107000-00008 [pii]
PST - ppublish
SO  - Acad Med. 2011 Jul;86(7):801-3. doi: 10.1097/ACM.0b013e31821da481.


PMID- 21715439
OWN - NLM
STAT- MEDLINE
DCOM- 20120501
LR  - 20120123
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 2
DP  - 2012 Feb
TI  - Physicians' Ethics Forum: a Web-based ethics consultation service.
PG  - 83-6
LID - 10.1136/jme.2010.037549 [doi]
AB  - To meet all physicians' needs for ethics consultation in Finland, a novel form of
      service, the Physicians' Ethics Forum, was founded in 2003. The Forum is a
      cost-efficient service based on electronic communication. In this paper,
      experiences throughout its first 6 years are described.
FAU - Louhiala, Pekka
AU  - Louhiala P
AD  - Vuorikatu 17 as 3, Hameenlinna, Finland. pekka.louhiala@helsinki.fi
FAU - Saarni, Samuli
AU  - Saarni S
FAU - Hietala, Katri
AU  - Hietala K
FAU - Pasternack, Amos
AU  - Pasternack A
LA  - eng
PT  - Journal Article
DEP - 20110629
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Attitude of Health Personnel
MH  - Ethicists
MH  - Ethics Consultation/*organization & administration
MH  - Finland
MH  - Humans
MH  - Internet
MH  - *Online Systems
MH  - Physicians
EDAT- 2011/07/01 06:00
MHDA- 2012/05/02 06:00
CRDT- 2011/07/01 06:00
PHST- 2011/07/01 06:00 [entrez]
PHST- 2011/07/01 06:00 [pubmed]
PHST- 2012/05/02 06:00 [medline]
AID - jme.2010.037549 [pii]
AID - 10.1136/jme.2010.037549 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Feb;38(2):83-6. doi: 10.1136/jme.2010.037549. Epub 2011 Jun
      29.


PMID- 21714870
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20220331
IS  - 1472-6920 (Electronic)
IS  - 1472-6920 (Linking)
VI  - 11
DP  - 2011 Jun 29
TI  - Evaluating professionalism in medical undergraduates using selected response
      questions: findings from an item response modelling study.
PG  - 43
LID - 10.1186/1472-6920-11-43 [doi]
AB  - BACKGROUND: Professionalism is a difficult construct to define in medical
      students but aspects of this concept may be important in predicting the risk of
      postgraduate misconduct. For this reason attempts are being made to evaluate
      medical students' professionalism. This study investigated the psychometric
      properties of Selected Response Questions (SRQs) relating to the theme of
      professional conduct and ethics comparing them with two sets of control items:
      those testing pure knowledge of anatomy, and; items evaluating the ability to
      integrate and apply knowledge ("skills"). The performance of students on the SRQs
      was also compared with two external measures estimating aspects of
      professionalism in students; peer ratings of professionalism and their
      Conscientiousness Index, an objective measure of behaviours at medical school.
      METHODS: Item Response Theory (IRT) was used to analyse both question and student
      performance for SRQs relating to knowledge of professionalism, pure anatomy and
      skills. The relative difficulties, discrimination and 'guessabilities' of each
      theme of question were compared with each other using Analysis of Variance
      (ANOVA). Student performance on each topic was compared with the measures of
      conscientiousness and professionalism using parametric and non-parametric tests
      as appropriate. A post-hoc analysis of power for the IRT modelling was conducted 
      using a Monte Carlo simulation. RESULTS: Professionalism items were less
      difficult compared to the anatomy and skills SRQs, poorer at discriminating
      between candidates and more erratically answered when compared to anatomy
      questions. Moreover professionalism item performance was uncorrelated with the
      standardised Conscientiousness Index scores (rho = 0.009, p = 0.90). In contrast 
      there were modest but significant correlations between standardised
      Conscientiousness Index scores and performance at anatomy items (rho = 0.20, p = 
      0.006) though not skills (rho = .11, p = .1). Likewise, students with high peer
      ratings for professionalism had superior performance on anatomy SRQs but not
      professionalism themed questions. A trend of borderline significance (p = .07)
      was observed for performance on skills SRQs and professionalism nomination
      status. CONCLUSIONS: SRQs related to professionalism are likely to have
      relatively poor psychometric properties and lack associations with other
      constructs associated with undergraduate professional behaviour. The findings
      suggest that such questions should not be included in undergraduate examinations 
      and may raise issues with the introduction of Situational Judgement Tests into
      Foundation Years selection.
FAU - Tiffin, Paul A
AU  - Tiffin PA
AD  - School for Medicine and Health, the Wolfson Research Institute, Durham University
      Queen's Campus, UK. p.a.tiffin@dur.ac.uk
FAU - Finn, Gabrielle M
AU  - Finn GM
FAU - McLachlan, John C
AU  - McLachlan JC
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110629
PL  - England
TA  - BMC Med Educ
JT  - BMC medical education
JID - 101088679
SB  - IM
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - *Education, Medical, Undergraduate
MH  - Humans
MH  - *Models, Theoretical
MH  - Monte Carlo Method
MH  - Professional Competence/*standards
MH  - Psychometrics/instrumentation
MH  - *Surveys and Questionnaires
PMC - PMC3146946
EDAT- 2011/07/01 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/07/01 06:00
PHST- 2011/02/08 00:00 [received]
PHST- 2011/06/29 00:00 [accepted]
PHST- 2011/07/01 06:00 [entrez]
PHST- 2011/07/01 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 1472-6920-11-43 [pii]
AID - 10.1186/1472-6920-11-43 [doi]
PST - epublish
SO  - BMC Med Educ. 2011 Jun 29;11:43. doi: 10.1186/1472-6920-11-43.


PMID- 21714865
OWN - NLM
STAT- MEDLINE
DCOM- 20140630
LR  - 20211020
IS  - 1297-9716 (Electronic)
IS  - 0928-4249 (Linking)
VI  - 42
DP  - 2011 Jun 29
TI  - Risk based culling for highly infectious diseases of livestock.
PG  - 81
LID - 10.1186/1297-9716-42-81 [doi]
AB  - The control of highly infectious diseases of livestock such as classical swine
      fever, foot-and-mouth disease, and avian influenza is fraught with ethical,
      economic, and public health dilemmas. Attempts to control outbreaks of these
      pathogens rely on massive culling of infected farms, and farms deemed to be at
      risk of infection. Conventional approaches usually involve the preventive culling
      of all farms within a certain radius of an infected farm. Here we propose a novel
      culling strategy that is based on the idea that farms that have the highest
      expected number of secondary infections should be culled first. We show that, in 
      comparison with conventional approaches (ring culling), our new method of risk
      based culling can reduce the total number of farms that need to be culled, the
      number of culled infected farms (and thus the expected number of human infections
      in case of a zoonosis), and the duration of the epidemic. Our novel risk based
      culling strategy requires three pieces of information, viz. the location of all
      farms in the area at risk, the moments when infected farms are detected, and an
      estimate of the distance-dependent probability of transmission.
FAU - te Beest, Dennis E
AU  - te Beest DE
AD  - Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht
      University, Yalelaan 7, 3584 CL, Utrecht, The Netherlands.
      dennis.te.beest@rivm.nl.
FAU - Hagenaars, Thomas J
AU  - Hagenaars TJ
FAU - Stegeman, J Arjan
AU  - Stegeman JA
FAU - Koopmans, Marion P G
AU  - Koopmans MP
FAU - van Boven, Michiel
AU  - van Boven M
LA  - eng
GR  - U19 CI000404-01/CI/NCPDCID CDC HHS/United States
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20110629
PL  - England
TA  - Vet Res
JT  - Veterinary research
JID - 9309551
SB  - IM
MH  - Animals
MH  - Communicable Disease Control/*methods
MH  - Communicable Diseases/epidemiology/etiology/*veterinary
MH  - Computer Simulation
MH  - Disease Outbreaks/*veterinary
MH  - Geography
MH  - *Livestock
MH  - Models, Biological
MH  - *Poultry
MH  - Risk Assessment
MH  - Time Factors
PMC - PMC3160900
EDAT- 2011/07/01 06:00
MHDA- 2014/07/01 06:00
CRDT- 2011/07/01 06:00
PHST- 2010/12/13 00:00 [received]
PHST- 2011/06/29 00:00 [accepted]
PHST- 2011/07/01 06:00 [entrez]
PHST- 2011/07/01 06:00 [pubmed]
PHST- 2014/07/01 06:00 [medline]
AID - 1297-9716-42-81 [pii]
AID - 10.1186/1297-9716-42-81 [doi]
PST - epublish
SO  - Vet Res. 2011 Jun 29;42:81. doi: 10.1186/1297-9716-42-81.


PMID- 21714415
OWN - NLM
STAT- MEDLINE
DCOM- 20110810
LR  - 20220311
IS  - 0966-8519 (Print)
IS  - 0966-8519 (Linking)
VI  - 20
IP  - 3
DP  - 2011 May
TI  - Mitral valve repair versus replacement in the elderly population.
PG  - 265-71
AB  - BACKGROUND AND AIM OF THE STUDY: The study aim was to evaluate the available
      literature comparing mitral valve repair (MVRep) versus mitral valve replacement 
      (MVR) in the elderly population, and to provide a pooled analysis regarding this 
      issue. METHODS: Medline, Embase, Cochrane, trial registries, conference
      proceedings and reference lists were searched for trials of MVRep versus MVR
      surgery in the elderly population. The primary outcome was 30-day mortality,
      while secondary outcomes were postoperative complications and length of hospital 
      stay. Pooled odds ratios were calculated for categorical outcomes and weighted
      mean differences for continuous outcomes. RESULTS: Four studies retrieved were
      deemed appropriate for inclusion. The outcome measures used for the analysis
      clearly showed a benefit of MVRep in the elderly population with reduced
      mortality (pooled Odds Ratio (OR) = 3.97; p = 0.003) and reduced postoperative
      complications (pooled OR = 2.35; p = 0.003). There was no significant difference 
      between the two groups with regards to duration of hospital stay (weighted mean
      difference = 0.22; p = 0.18). CONCLUSION: With the demonstration of clear
      advantages of MVRep over MVR in the elderly population, a randomized trial
      between the two techniques is not ethically justifiable. As there are clear
      advantages to MVRep, it is recommended that this should be the primary treatment 
      offered in mitral valve pathology, irrespective of the patient's age.
FAU - Markar, Sheraz R
AU  - Markar SR
AD  - Department of Cardiothoracic Surgery, Papworth Hospital, Cambridge, UK.
FAU - Sadat, Umar
AU  - Sadat U
FAU - Edmonds, Lynn
AU  - Edmonds L
FAU - Nair, Sukumaran K
AU  - Nair SK
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PL  - England
TA  - J Heart Valve Dis
JT  - The Journal of heart valve disease
JID - 9312096
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - *Aging
MH  - *Cardiac Surgical Procedures/adverse effects/mortality
MH  - England
MH  - Evidence-Based Medicine
MH  - Female
MH  - Heart Valve Diseases/mortality/*surgery
MH  - *Heart Valve Prosthesis Implantation/adverse effects/mortality
MH  - Humans
MH  - Length of Stay
MH  - Male
MH  - Mitral Valve/*surgery
MH  - Odds Ratio
MH  - Patient Selection
MH  - Risk Assessment
MH  - Risk Factors
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2011/07/01 06:00
MHDA- 2011/08/11 06:00
CRDT- 2011/07/01 06:00
PHST- 2011/07/01 06:00 [entrez]
PHST- 2011/07/01 06:00 [pubmed]
PHST- 2011/08/11 06:00 [medline]
PST - ppublish
SO  - J Heart Valve Dis. 2011 May;20(3):265-71.


PMID- 21714327
OWN - NLM
STAT- MEDLINE
DCOM- 20110809
LR  - 20211020
IS  - 0008-4263 (Print)
IS  - 0008-4263 (Linking)
VI  - 102
IP  - 3
DP  - 2011 May-Jun
TI  - Re: Outram SM. Epidemiology and bioethics: a plea for reconnecting with the
      public. [Ethics in public health] Can J Public Health 2011;102(1):4-6.
PG  - 236; author reply 236
FAU - Soskolne, Colin L
AU  - Soskolne CL
LA  - eng
PT  - Comment
PT  - Letter
PL  - Switzerland
TA  - Can J Public Health
JT  - Canadian journal of public health = Revue canadienne de sante publique
JID - 0372714
SB  - IM
CON - Can J Public Health. 2011 Jan-Feb;102(1):4-6. PMID: 21485959
MH  - *Codes of Ethics
MH  - Epidemiology/*ethics
MH  - Humans
PMC - PMC6974025
EDAT- 2011/07/01 06:00
MHDA- 2011/08/10 06:00
CRDT- 2011/07/01 06:00
PHST- 2011/07/01 06:00 [entrez]
PHST- 2011/07/01 06:00 [pubmed]
PHST- 2011/08/10 06:00 [medline]
PST - ppublish
SO  - Can J Public Health. 2011 May-Jun;102(3):236; author reply 236.


PMID- 21714321
OWN - NLM
STAT- MEDLINE
DCOM- 20110809
LR  - 20211020
IS  - 0008-4263 (Print)
IS  - 0008-4263 (Linking)
VI  - 102
IP  - 3
DP  - 2011 May-Jun
TI  - Making the case for human rights in global health education, research and policy.
PG  - 207-9
AB  - If the 2010 CPHA conference is a bellwether of mainstream Canadian public and
      global health practice, its dearth of human rights papers suggests that, outside 
      a small scholarly cohort, human rights remain marginal therein. This potential
      'rights gap' conflicts with growing recognition of the relationship between
      health and human rights and ergo, the importance of human rights education for
      health professionals. This gap not only places Canadian health research outside
      the growing vanguard of academic research on health and human rights, but also
      ignores a potentially influential tool for achieving health equity. I suggest
      that human rights make a distinctive contribution to such efforts not replicated 
      within other social justice and equity approaches, making human rights education 
      a crucial complement to other ethical training. These contributions are evident
      in the normative specificity of the right to health in international law and its 
      legally binding nature, in the success of litigation, the successful advocacy for
      AIDS treatment and the growing adoption of rights-based approaches to health.
      Canadian academic and research institutions should take up their rightful place
      within health and human rights research, education and practice globally,
      including by ramping up human rights-oriented education for health professionals 
      within Canadian universities.
FAU - Forman, Lisa
AU  - Forman L
AD  - Dalla Lana School of Public Health, University of Toronto, 155 College Street,
      Toronto, ON M5T 3M7. lisa.forman@utoronto.ca
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Can J Public Health
JT  - Canadian journal of public health = Revue canadienne de sante publique
JID - 0372714
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - Anti-HIV Agents/economics
MH  - Canada
MH  - *Education, Professional
MH  - *Global Health
MH  - HIV Infections/drug therapy
MH  - Health Services Accessibility/*legislation & jurisprudence
MH  - Health Status Disparities
MH  - Healthcare Disparities
MH  - Human Rights/*legislation & jurisprudence
MH  - Humans
MH  - International Cooperation
MH  - *Research
PMC - PMC6973942
EDAT- 2011/07/01 06:00
MHDA- 2011/08/10 06:00
CRDT- 2011/07/01 06:00
PHST- 2011/07/01 06:00 [entrez]
PHST- 2011/07/01 06:00 [pubmed]
PHST- 2011/08/10 06:00 [medline]
PST - ppublish
SO  - Can J Public Health. 2011 May-Jun;102(3):207-9.


PMID- 21714320
OWN - NLM
STAT- MEDLINE
DCOM- 20110809
LR  - 20211020
IS  - 0008-4263 (Print)
IS  - 0008-4263 (Linking)
VI  - 102
IP  - 3
DP  - 2011 May-Jun
TI  - Why are some settings resource-poor and others not? The global marketplace,
      perfect economic storms, and the right to health.
PG  - 204-6
AB  - Analyses of how health system priorities should be set in resource-poor settings 
      are routine in the health ethics and policy analysis literature. Less attention
      is devoted to asking why some settings are resource-poor and others not. Asking
      this question must be considered a central task of global health research.
      Comparison of the relatively meager resources devoted to improving the health of 
      the poor with the sums routinely mobilized for other purposes serves as a basis
      for ethical reflection and a route into necessary questioning of power imbalances
      in the world economy. The 2008 financial crisis and related developments
      underscore the urgency of such questioning, and the value of research and
      advocacy collaborations (for example, between the human rights and public health 
      research and practice communities) focused specifically on the destructive
      consequences of the global marketplace for health.
FAU - Schrecker, Ted
AU  - Schrecker T
AD  - Institute of Population Health, University of Ottawa, 1 Stewart Street, Ottawa,
      ON K1N 6N5. tschrecker@gmail.com
LA  - eng
GR  - 103729/Canadian Institutes of Health Research/Canada
GR  - 79153/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Can J Public Health
JT  - Canadian journal of public health = Revue canadienne de sante publique
JID - 0372714
SB  - IM
MH  - Economic Recession
MH  - *Global Health
MH  - *Healthcare Disparities
MH  - *Human Rights
MH  - Humans
MH  - Internationality
MH  - *Resource Allocation
MH  - Social Responsibility
PMC - PMC6974247
EDAT- 2011/07/01 06:00
MHDA- 2011/08/10 06:00
CRDT- 2011/07/01 06:00
PHST- 2011/07/01 06:00 [entrez]
PHST- 2011/07/01 06:00 [pubmed]
PHST- 2011/08/10 06:00 [medline]
PST - ppublish
SO  - Can J Public Health. 2011 May-Jun;102(3):204-6.


PMID- 21701277
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110928
LR  - 20110624
IS  - 1538-9774 (Electronic)
IS  - 1538-2931 (Linking)
VI  - 29
IP  - 6 Suppl
DP  - 2011 Jun
TI  - Comparing the teaching-learning process with and without the use of computerized 
      technological resources.
PG  - TC89-97
LID - 10.1097/NCN.0b013e3182285c2e [doi]
AB  - Computerized technological resources have become essential in education,
      particularly for teaching topics that require the performance of specific tasks. 
      These resources can effectively help the execution of such tasks and the
      teaching-learning process itself. After the development of a Web site on the
      topic of nursing staff scheduling, this study aimed at comparing the development 
      of students involved in the teaching-learning process of the previously mentioned
      topic, with and without the use of computer technology. Two random groups of
      undergraduate nursing students from a public university in Sao Paulo state,
      Brazil, were organized: a case group (used the Web site) and a control group (did
      not use the Web site). Data were collected from 2003 to 2005 after approval by
      the Research Ethics Committee. Results showed no significant difference in
      motivation or knowledge acquisition. A similar performance for the two groups was
      also verified. Other aspects observed were difficulty in doing the nursing staff 
      scheduling exercise and the students' acknowledgment of the topic's importance
      for their training and professional lives; easy access was considered to be a
      positive aspect for maintaining the Web site.
FAU - Juliani, Carmen Maria Casquel Monti
AU  - Juliani CM
AD  - Department of Nursing, Botucatu School of Medicine, Sao Paulo State University,
      UNESP, Brazil. cjuliani@fmb.unesp.br
FAU - Corrente, Jose Eduardo
AU  - Corrente JE
FAU - Dell'Acqua, Magda Cristina Queiroz
AU  - Dell'Acqua MC
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Comput Inform Nurs
JT  - Computers, informatics, nursing : CIN
JID - 101141667
RPF - Comput Inform Nurs. 2011 Apr;29(4):212-20. PMID: 20978437
EDAT- 2011/07/01 06:00
MHDA- 2011/07/01 06:01
CRDT- 2011/06/25 06:00
PHST- 2011/06/25 06:00 [entrez]
PHST- 2011/07/01 06:00 [pubmed]
PHST- 2011/07/01 06:01 [medline]
AID - 10.1097/NCN.0b013e3182285c2e [doi]
AID - 00024665-201106001-00004 [pii]
PST - ppublish
SO  - Comput Inform Nurs. 2011 Jun;29(6 Suppl):TC89-97. doi:
      10.1097/NCN.0b013e3182285c2e.


PMID- 21692923
OWN - NLM
STAT- MEDLINE
DCOM- 20110914
LR  - 20141120
IS  - 1365-2516 (Electronic)
IS  - 1351-8216 (Linking)
VI  - 17 Suppl 1
DP  - 2011 Jul
TI  - Prenatal diagnosis and preimplantation genetic diagnosis: novel technologies and 
      state of the art of PGD in different regions of the world.
PG  - 14-7
LID - 10.1111/j.1365-2516.2011.02559.x [doi]
AB  - Prenatal diagnosis (PND) aims to provide accurate, rapid results as early in
      pregnancy as possible. Conventional PND involves sampling cells of foetal origin 
      by chorionic villus sampling at 11-14th weeks of pregnancy or amniocentesis after
      15th week. These are invasive procedures and have a small but significant rate of
      0.5% to 1% for loss of pregnancy. An alternative to existing methods for
      conventional PND for couples at risk of transmitting a genetic disease to their
      child is preimplantation genetic diagnosis (PGD). PGD is a newly emerging form of
      a very early prenatal diagnosis. The technique combines assisted reproductive
      technology with molecular genetics and cytogenetics to allow the identification
      of abnormality in embryos prior to implantation. The diagnosis of genetic disease
      in human preimplantation embryos was pioneered in the late 1980s for testing of
      aneuploidy, single gene and X-linked disease, such as cystic fibrosis,
      haemophilia and chromosomal abnormalities. The PGD-related legal and ethical
      issues have been debated at many levels both nationally and internationally. The 
      attitude towards PGD varies substantially not only in different parts of the
      world but also within the Europe, owing to scientific, cultural and religious
      differences. PGD has become widely practised throughout the world for various
      indications and can substantially decrease the eventual risks of passing a
      genetic undesired condition of the offspring. Nevertheless, its extension to some
      new and non-medical indications has raised ethical concerns, in particular its
      potential eugenic dimension.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Peyvandi, F
AU  - Peyvandi F
AD  - U.O.S. Dipartimentale per la Diagnosi e la Terapia delle Coagulopatie, A. Bianchi
      Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca Granda Ospedale
      Maggiore Policlinico, Universita degli Studi di Milano and Luigi Villa
      Foundation, Milan, Italy. flora.peyvandi@unimi.it
FAU - Garagiola, I
AU  - Garagiola I
FAU - Mortarino, M
AU  - Mortarino M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Haemophilia
JT  - Haemophilia : the official journal of the World Federation of Hemophilia
JID - 9442916
SB  - IM
MH  - Blood Coagulation Disorders, Inherited/*diagnosis/*genetics
MH  - Female
MH  - Genetic Counseling/methods
MH  - Global Health
MH  - Humans
MH  - Pregnancy
MH  - Preimplantation Diagnosis/*methods
MH  - Prenatal Diagnosis/*methods
EDAT- 2011/07/01 06:00
MHDA- 2011/09/15 06:00
CRDT- 2011/06/23 06:00
PHST- 2011/06/23 06:00 [entrez]
PHST- 2011/07/01 06:00 [pubmed]
PHST- 2011/09/15 06:00 [medline]
AID - 10.1111/j.1365-2516.2011.02559.x [doi]
PST - ppublish
SO  - Haemophilia. 2011 Jul;17 Suppl 1:14-7. doi: 10.1111/j.1365-2516.2011.02559.x.


PMID- 29783331
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220311
IS  - 1744-828X (Electronic)
IS  - 1741-0541 (Linking)
VI  - 8
IP  - 4
DP  - 2011 Jul
TI  - Knowledge and attitudes concerning pharmacogenomics among healthcare
      professionals.
PG  - 421-428
LID - 10.2217/pme.11.28 [doi]
AB  - Pharmacogenomics has become an area of great potential in the medical community. 
      Therefore, the assessment of the knowledge and attitudes among healthcare
      professionals is essential. The purpose of this systematic literature review is
      to explore the knowledge and attitudes of healthcare professionals regarding
      pharmacogenetic testing with a specific emphasis in oncology. A total of 12
      articles were found and reviewed. A majority of the articles reported only on the
      attitudes of healthcare professionals. Four of the articles reported on both
      knowledge and attitudes of healthcare professionals concerning pharmacogenetic
      testing, and one article reported only on the knowledge level of healthcare
      professionals. This systematic literature review revealed that healthcare
      professionals generally perceive themselves to have limited knowledge regarding
      pharmacogenetic testing. In addition, these articles highlighted the overwhelming
      ethical concerns surrounding pharmacogenomics. However, these articles also
      revealed that healthcare professionals believed that there were also many
      advantages regarding the utilization of pharmacogenomics.
FAU - Dodson, Crystal
AU  - Dodson C
AD  - University of North Carolina, Chapel Hill, Department of Social Medicine, 347A
      MacNider, CB 7240, Columbia Street, Chapel Hill, NC 27599-27240, USA.
      chdodson@email.unc.edu.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Per Med
JT  - Personalized medicine
JID - 101238549
OTO - NOTNLM
OT  - attitude(s)
OT  - healthcare professionals
OT  - knowledge
OT  - personalized medicine
OT  - pharmacogenomics
EDAT- 2011/07/01 00:00
MHDA- 2011/07/01 00:01
CRDT- 2018/05/23 06:00
PHST- 2018/05/23 06:00 [entrez]
PHST- 2011/07/01 00:00 [pubmed]
PHST- 2011/07/01 00:01 [medline]
AID - 10.2217/pme.11.28 [doi]
PST - ppublish
SO  - Per Med. 2011 Jul;8(4):421-428. doi: 10.2217/pme.11.28.


PMID- 25949652
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150507
LR  - 20200930
IS  - 1757-1472 (Print)
IS  - 1757-1472 (Linking)
VI  - 4
IP  - 1
DP  - 2011 Jul
TI  - Everyday ethics: learning from an 'ordinary' consultation in general practice.
PG  - 72-6
AB  - The author uses a constructed case to analyse some of the ethical decisions that 
      UK general practitioners face in everyday settings. A variety of ethical
      frameworks and empirical primary healthcare literature are used to demonstrate
      how ethical tools may be used by clinicians in primary healthcare to reflect on
      their decisions in practice. The GP consultation context can make 'on the spot'
      ethical decisions difficult and varied.
FAU - Allison, Caroline
AU  - Allison C
AD  - GP and MSc Student, Department of Public Health and Primary Care, King's College 
      London, UK.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - London J Prim Care (Abingdon)
JT  - London journal of primary care
JID - 101576301
PMC - PMC3960671
OTO - NOTNLM
OT  - Four Principles
OT  - autonomy
OT  - clinical decision making
OT  - ethics
OT  - justice
OT  - primary care
OT  - resource allocation
EDAT- 2011/07/01 00:00
MHDA- 2011/07/01 00:01
CRDT- 2015/05/08 06:00
PHST- 2011/03/22 00:00 [received]
PHST- 2011/03/28 00:00 [accepted]
PHST- 2015/05/08 06:00 [entrez]
PHST- 2011/07/01 00:00 [pubmed]
PHST- 2011/07/01 00:01 [medline]
PST - ppublish
SO  - London J Prim Care (Abingdon). 2011 Jul;4(1):72-6.


PMID- 25949651
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150507
LR  - 20200930
IS  - 1757-1472 (Print)
IS  - 1757-1472 (Linking)
VI  - 4
IP  - 1
DP  - 2011 Jul
TI  - Ethics of the ordinary: a meeting run by the Royal Society of Medicine with the
      Royal College of General Practitioners.
PG  - 69-71
FAU - Papanikitas, Andrew
AU  - Papanikitas A
AD  - PhD Student, Department of Education and Professional Studies and Sessional
      Tutor, Department of Public Health and Primary Care, King's College London, UK.
FAU - De Zulueta, Paquita
AU  - De Zulueta P
AD  - Honorary Lecturer in Medical Ethics, Imperial College London and Tutor in Medical
      Ethics, Kings College London, UK.
FAU - Spicer, John
AU  - Spicer J
AD  - Head of General Practice School, London Deanery, UK.
FAU - Knight, Rhona
AU  - Knight R
AD  - RCGP Ethics Committee and Portfolio GP, UK.
FAU - Toon, Peter
AU  - Toon P
AD  - Honorary Lecturer, Honorary Lecturer, Queen Mary University of London, UK.
FAU - Misselbrook, David
AU  - Misselbrook D
AD  - Dean, Royal Society of Medicine, UK.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - London J Prim Care (Abingdon)
JT  - London journal of primary care
JID - 101576301
PMC - PMC3960673
EDAT- 2011/07/01 00:00
MHDA- 2011/07/01 00:01
CRDT- 2015/05/08 06:00
PHST- 2011/03/21 00:00 [received]
PHST- 2011/03/23 00:00 [accepted]
PHST- 2015/05/08 06:00 [entrez]
PHST- 2011/07/01 00:00 [pubmed]
PHST- 2011/07/01 00:01 [medline]
PST - ppublish
SO  - London J Prim Care (Abingdon). 2011 Jul;4(1):69-71.


PMID- 24478952
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20220310
IS  - 2231-0762 (Print)
IS  - 2231-0762 (Linking)
VI  - 1
IP  - 2
DP  - 2011 Jul
TI  - Applications of teledentistry: A literature review and update.
PG  - 37-44
LID - 10.4103/2231-0762.97695 [doi]
AB  - Teledentistry is a combination of telecommunications and dentistry involving the 
      exchange of clinical information and images over remote distances for dental
      consultation and treatment planning. Teledentistry has the ability to improve
      access to oral healthcare, improve the delivery of oral healthcare, and lower its
      costs. It also has the potential to eliminate the disparities in oral health care
      between rural and urban communities. This article reviews the origin, rationale, 
      scope, basis, and requirements for teledentistry, along with the current evidence
      that exists in the literature. This article also reviews the ethical and legal
      issues related to the practice of teledentistry and the future of this
      alternative and innovative method of delivering dental care.
FAU - Jampani, N D
AU  - Jampani ND
AD  - Department of Periodontics, Government Dental College & Hospital, Vijayawada,
      India.
FAU - Nutalapati, R
AU  - Nutalapati R
AD  - Department of Periodontics, Sree Sai Dental College & Research Institute,
      Srikakulam, Andhra Pradesh, India.
FAU - Dontula, B S K
AU  - Dontula BS
AD  - Department of Conservative Dentistry & Endodontics, Aditya Dental College, Beed, 
      Maharashtra, India.
FAU - Boyapati, R
AU  - Boyapati R
AD  - Department of Periodontics, Sibar Institute of Dental Sciences, Guntur, Andhra
      Pradesh, India.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - India
TA  - J Int Soc Prev Community Dent
JT  - Journal of International Society of Preventive & Community Dentistry
JID - 101618802
PMC - PMC3894070
OTO - NOTNLM
OT  - Information technology
OT  - internet
OT  - teleconsultation
OT  - teledentistry
OT  - telediagnosis
OT  - telemedicine
EDAT- 2011/07/01 00:00
MHDA- 2011/07/01 00:01
CRDT- 2014/01/31 06:00
PHST- 2014/01/31 06:00 [entrez]
PHST- 2011/07/01 00:00 [pubmed]
PHST- 2011/07/01 00:01 [medline]
AID - 10.4103/2231-0762.97695 [doi]
AID - JISPCD-1-37 [pii]
PST - ppublish
SO  - J Int Soc Prev Community Dent. 2011 Jul;1(2):37-44. doi: 10.4103/2231-0762.97695.


PMID- 24367468
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131224
LR  - 20211021
IS  - 1885-642X (Print)
IS  - 1885-642X (Linking)
VI  - 9
IP  - 3
DP  - 2011 Jul
TI  - The perceptions of pharmacists in Victoria, Australia on pharmacogenetics and its
      implications.
PG  - 141-7
AB  - OBJECTIVE: This study aimed to explore how well Victorian pharmacists perceived
      they understood pharmacogenetics, their perceived capacity to counsel a patient
      about such testing, how they believed pharmacogenetics would impact upon their
      profession, and to investigate the ways in which Victorian pharmacists would like
      to be educated about pharmacogenetics. METHODS: A cross-sectional survey was
      dispatched to 800 Victorian pharmacists. The participants were randomly selected 
      and the survey was anonymous. The survey contained questions about where the
      pharmacists worked, the pharmacists' perceived knowledge of pharmacogenetics, how
      well they believed they would be able to counsel patients about pharmacogenetic
      testing, how they thought pharmacists should be educated on the topic and how
      they believed pharmacogenetics would impact upon their profession. RESULTS: 291
      surveys were returned (36% response rate). Results suggest that Victorian
      pharmacists generally perceived they had a poor understanding of pharmacogenetics
      and that those who have more recently graduated from tertiary education had a
      better perceived understanding than those who have been in the workforce for
      longer. Most pharmacists indicated that they did not believe that they could
      counsel a patient adequately about the results of a pharmacogenetic test.
      Regarding education about pharmacogenetics, participants suggested that this
      would be best delivered during tertiary studies, and as seminars and workshops
      forming part of their continuing professional development. Although some
      pharmacists were unsure how pharmacogenetics would affect their profession, many 
      believed it would have a major impact upon their role as a pharmacist and lead to
      improved patient care. Some concerns about the implementation of pharmacogenetics
      were noted, including economic and ethical issues. CONCLUSIONS: This study
      highlights the need for further research across the pharmacy profession in
      Australia on the issue of preparedness for the putative incorporation of
      pharmacogenetics into the healthcare system and everyday practice.
FAU - McMahon, Teresa
AU  - McMahon T
AD  - School of Pharmacy & Applied Science, La Trobe University . Bendigo, Victoria (
      Australia ).
FAU - Tucci, Joseph
AU  - Tucci J
AD  - School of Pharmacy & Applied Science, La Trobe University . Bendigo, Victoria (
      Australia ).
LA  - eng
PT  - Journal Article
DEP - 20110914
PL  - Spain
TA  - Pharm Pract (Granada)
JT  - Pharmacy practice
JID - 101530029
PMC - PMC3870173
OTO - NOTNLM
OT  - Australia
OT  - Health Knowledge, Attitudes, Practice
OT  - Pharmacists
OT  - Pharmacogenetics
EDAT- 2011/07/01 00:00
MHDA- 2011/07/01 00:01
CRDT- 2013/12/25 06:00
PHST- 2011/05/12 00:00 [received]
PHST- 2011/08/06 00:00 [accepted]
PHST- 2013/12/25 06:00 [entrez]
PHST- 2011/07/01 00:00 [pubmed]
PHST- 2011/07/01 00:01 [medline]
PST - ppublish
SO  - Pharm Pract (Granada). 2011 Jul;9(3):141-7. Epub 2011 Sep 14.


PMID- 23908811
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130805
LR  - 20211021
IS  - 2076-9172 (Print)
IS  - 2076-9172 (Linking)
VI  - 2
IP  - 3
DP  - 2011 Jul
TI  - The Future of Children's Health in the Genomic Era.
PG  - e0053
LID - 10.5041/RMMJ.10053 [doi]
AB  - The effects of genomic medicine on child health promise to be profound. Medical
      applications will eventually include characterizing patients' genomes to detect
      predictive mutations for pre-symptomatic counseling where treatment exists; to
      search for causes of diseases of unknown etiology, and to detect carriers for
      prenatal counseling; to define cancer and other disease-based genomes to design
      individualized therapy; and to understand our microbiomes to modify these in
      health and disease. Rapid advances in technology and bioinformatics have reduced 
      the cost and the time and increased the accuracy necessary to sequence whole
      genomes or whole exomes. However, complete understanding of disease will also
      require correlation of genomic information with high-quality phenotypic data. In 
      addition, several critical ethical, psycho-social, and public policy issues will 
      require clarity in the coming years. Ultimately these advances will improve the
      effectiveness of health care for children and for society.
FAU - Schwartz, Alan L
AU  - Schwartz AL
AD  - The Harriet B. Spoehrer Professor and Chairman, Department of Pediatrics,
      Washington University School of Medicine, St Louis, MO, USA.
LA  - eng
PT  - Journal Article
DEP - 20110731
PL  - Israel
TA  - Rambam Maimonides Med J
JT  - Rambam Maimonides medical journal
JID - 101538065
PMC - PMC3678796
OTO - NOTNLM
OT  - Genomics
OT  - bioinformatics
OT  - child/children
OT  - genetics
OT  - microbiome
OT  - pediatrics
EDAT- 2011/07/01 00:00
MHDA- 2011/07/01 00:01
CRDT- 2013/08/03 06:00
PHST- 2013/08/03 06:00 [entrez]
PHST- 2011/07/01 00:00 [pubmed]
PHST- 2011/07/01 00:01 [medline]
AID - 10.5041/RMMJ.10053 [doi]
AID - rmmj-2-3-e0053 [pii]
PST - epublish
SO  - Rambam Maimonides Med J. 2011 Jul 31;2(3):e0053. doi: 10.5041/RMMJ.10053. Print
      2011 Jul.


PMID- 23509676
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130704
LR  - 20211021
IS  - 2229-5070 (Print)
IS  - 2229-5070 (Linking)
VI  - 1
IP  - 2
DP  - 2011 Jul
TI  - Ethics and clinical research.
PG  - 54-6
LID - 10.4103/2229-5070.86925 [doi]
FAU - Mandal, Jharna
AU  - Mandal J
AD  - Department of Microbiology, JIPMER, Puducherry, India E-mail:
      subhashparija@yahoo.co.in.
FAU - Halder, Ajay
AU  - Halder A
FAU - Parija, Subhash Chandra
AU  - Parija SC
LA  - eng
PT  - Journal Article
PL  - India
TA  - Trop Parasitol
JT  - Tropical parasitology
JID - 101580198
PMC - PMC3593476
EDAT- 2011/07/01 00:00
MHDA- 2011/07/01 00:01
CRDT- 2013/03/20 06:00
PHST- 2011/06/06 00:00 [received]
PHST- 2011/10/31 00:00 [accepted]
PHST- 2013/03/20 06:00 [entrez]
PHST- 2011/07/01 00:00 [pubmed]
PHST- 2011/07/01 00:01 [medline]
AID - 10.4103/2229-5070.86925 [doi]
AID - TP-1-54 [pii]
PST - ppublish
SO  - Trop Parasitol. 2011 Jul;1(2):54-6. doi: 10.4103/2229-5070.86925.


PMID- 23408761
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130215
LR  - 20220317
IS  - 2008-2835 (Print)
IS  - 2008-2835 (Linking)
VI  - 3
IP  - 3
DP  - 2011 Jul
TI  - Differentiation of bovine spermatogonial stem cells into osteoblasts.
PG  - 149-53
AB  - Spermatogonial Stem Cell (SSC) technologies provide multiple opportunities for
      research in the field of biotechnology and regenerative medicine. The therapeutic
      use of Embryonic Stem Cells (ESCs) is restricted due to severe ethical and
      immunological concerns. Therefore, we need a new pluripotent cell type. Despite
      well-known role of germ cells in the gametogenesis, some facts apparently show
      their multipotentiality. In the present study, bovine SSCs were co-cultured with 
      Sertoli cell for 7 days. Sertoli cells and SSCs were identified by Vimentin and
      Oct-4 immunocytochemical staining method, respectively. In order to differentiate
      SSCs into osteoblasts, we used consecutive inducer media without separation of
      the colonies. We characterized osteoblasts using Alizarin red staining.
FAU - Qasemi-Panahi, Babak
AU  - Qasemi-Panahi B
AD  - Department of Clinical Science, Faculty of Veterinary Medicine, University of
      Tehran, Tehran, Iran.
FAU - Tajik, Parviz
AU  - Tajik P
FAU - Movahedin, Mansoureh
AU  - Movahedin M
FAU - Moghaddam, Gholamali
AU  - Moghaddam G
FAU - Barzgar, Younes
AU  - Barzgar Y
FAU - Heidari-Vala, Hamed
AU  - Heidari-Vala H
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Avicenna J Med Biotechnol
JT  - Avicenna journal of medical biotechnology
JID - 101511065
PMC - PMC3558187
OTO - NOTNLM
OT  - Differentiation
OT  - Osteoblast
OT  - Spermatogonial stem cell
EDAT- 2011/07/01 00:00
MHDA- 2011/07/01 00:01
CRDT- 2013/02/15 06:00
PHST- 2011/03/08 00:00 [received]
PHST- 2011/08/13 00:00 [accepted]
PHST- 2013/02/15 06:00 [entrez]
PHST- 2011/07/01 00:00 [pubmed]
PHST- 2011/07/01 00:01 [medline]
PST - ppublish
SO  - Avicenna J Med Biotechnol. 2011 Jul;3(3):149-53.


PMID- 23272457
OWN - NLM
STAT- MEDLINE
DCOM- 20130122
LR  - 20151119
IS  - 1025-9589 (Print)
IS  - 1025-9589 (Linking)
VI  - 23
IP  - 3
DP  - 2011 Jul-Sep
TI  - Perceptions of cadaveric dissection in anatomy teaching.
PG  - 145-8
AB  - BACKGROUND: Anatomy professors world over are lamenting about medical students'
      lack of interest in dissections and its diminishing utilisation in medical
      studies. The objective of our study was to find out the reasons why some of the
      Pakistani medical students were avoiding dissections. METHOD: We conducted this
      study in 5 medical colleges of Pakistan from Dec 2010-Oct 2011. Questionnaires
      were prepared and administered to more than 500 Pakistani medical students, at
      least 6 months after their first cadaver dissecting session. Mostly 1st and 2nd
      year medical students participated in this study. RESULT: Around 43% students
      have actually performed dissections in some form, whereas around 57% had never
      touched the cadaver. Further evaluation of these results revealed that out of 57%
      of students, 45% avoided dissection due to bad smell of formaldehyde, 37% due to 
      moral/ethical grounds, 22% due to low motivation and respect of human body, 19.4%
      due to anxiety, 18.6% due to religious reason, 16% due to fear, asthma and
      emotional reaction, 9.4% due to toxic chemical, 8.6% due to laziness and 7% due
      to nightmares. CONCLUSION: In spite of availability of required number of
      cadavers in all 5 medical colleges and a clear realisation amongst the students
      that dissecting cadaver is an effective way of learning anatomy; majority of
      students were not very keen and had therefore not performed dissection even once.
FAU - Naz, Saima
AU  - Naz S
AD  - Northern Institute of Medical Sciences, Abbottabad, Pakistan.
      Saimasaad2010@yahoo.com
FAU - Nazir, Ghazala
AU  - Nazir G
FAU - Iram, Samia
AU  - Iram S
FAU - Mohammad, Malik
AU  - Mohammad M
FAU - Umair
AU  - Umair
FAU - Qari, Iftikhar Hussain
AU  - Qari IH
FAU - Mohammad, Shaheen
AU  - Mohammad S
LA  - eng
PT  - Journal Article
PL  - Pakistan
TA  - J Ayub Med Coll Abbottabad
JT  - Journal of Ayub Medical College, Abbottabad : JAMC
JID - 8910750
SB  - IM
MH  - Adolescent
MH  - *Attitude
MH  - Dissection/*education
MH  - Female
MH  - Humans
MH  - Male
MH  - Students, Medical/*psychology
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2011/07/01 00:00
MHDA- 2013/01/23 06:00
CRDT- 2013/01/01 06:00
PHST- 2013/01/01 06:00 [entrez]
PHST- 2011/07/01 00:00 [pubmed]
PHST- 2013/01/23 06:00 [medline]
PST - ppublish
SO  - J Ayub Med Coll Abbottabad. 2011 Jul-Sep;23(3):145-8.


PMID- 23198482
OWN - NLM
STAT- MEDLINE
DCOM- 20130108
LR  - 20121203
IS  - 1029-4864 (Print)
IS  - 1029-4864 (Linking)
VI  - 66
IP  - 6
DP  - 2011 Jul
TI  - Dental ethics case 13. What do I do when I suspect that my elderly patient is
      being abused?
PG  - 297
FAU - Naidoo, S
AU  - Naidoo S
AD  - Department of Community Oral Health, University of the Western Cape, Private Bag 
      X1, Tygerberg, 7505. suenaidoo@uwc.ac.za
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - SADJ
JT  - SADJ : journal of the South African Dental Association = tydskrif van die
      Suid-Afrikaanse Tandheelkundige Vereniging
JID - 9812497
MH  - Aged
MH  - Aged, 80 and over
MH  - Dentists/*ethics
MH  - Elder Abuse/*diagnosis/ethics/legislation & jurisprudence
MH  - *Ethics, Dental
MH  - Humans
MH  - Mandatory Reporting/ethics
MH  - Middle Aged
MH  - Patient Advocacy/ethics
MH  - South Africa
EDAT- 2011/07/01 00:00
MHDA- 2013/01/09 06:00
CRDT- 2012/12/04 06:00
PHST- 2012/12/04 06:00 [entrez]
PHST- 2011/07/01 00:00 [pubmed]
PHST- 2013/01/09 06:00 [medline]
PST - ppublish
SO  - SADJ. 2011 Jul;66(6):297.


PMID- 23022834
OWN - NLM
STAT- MEDLINE
DCOM- 20130603
LR  - 20121001
IS  - 2008-6520 (Print)
IS  - 2008-6520 (Linking)
VI  - 2
IP  - 3
DP  - 2011 Jul
TI  - Sharing research findings with research participants and communities.
PG  - 172-81
AB  - In occupational and environmental health research, individual, group and
      community research participants have a unique and vested interest in the research
      findings. The ethical principles of autonomy, non-maleficence and beneficence are
      helpful in considering the ethical issues in the disclosure of research findings 
      in occupational and environmental health research. Researchers need to include
      stakeholders, such as groups and communities, in these discussions and in
      planning for the dissemination of research findings. These discussions need to
      occur early in the research process.
FAU - Ferris, L E
AU  - Ferris LE
AD  - Dalla Lana School of Public Health, University of Toronto, Ontario, Canada.
      Lorraine.Ferris@utoronto.ca
FAU - Sass-Kortsak, A
AU  - Sass-Kortsak A
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Int J Occup Environ Med
JT  - The international journal of occupational and environmental medicine
JID - 101535763
SB  - IM
MH  - *Biomedical Research
MH  - Communication
MH  - Disclosure/*ethics
MH  - Environmental Exposure
MH  - Environmental Health
MH  - *Ethics, Research
MH  - Humans
MH  - Informed Consent
MH  - *Occupational Exposure
EDAT- 2011/07/01 00:00
MHDA- 2013/06/05 06:00
CRDT- 2012/10/02 06:00
PHST- 2012/10/02 06:00 [entrez]
PHST- 2011/07/01 00:00 [pubmed]
PHST- 2013/06/05 06:00 [medline]
AID - 99 [pii]
PST - ppublish
SO  - Int J Occup Environ Med. 2011 Jul;2(3):172-81.


PMID- 22984755
OWN - NLM
STAT- MEDLINE
DCOM- 20121025
LR  - 20161021
IS  - 1134-7198 (Print)
IS  - 1134-7198 (Linking)
IP  - 35
DP  - 2011 Jul-Dec
TI  - Human genome and open source: balancing ethics and business.
PG  - 225-38
AB  - The Human Genome Project has been completed thanks to a massive use of computer
      techniques, as well as the adoption of the open-source business and research
      model by the scientists involved. This model won over the proprietary model and
      allowed a quick propagation and feedback of research results among peers. In this
      paper, the author will analyse some ethical and legal issues emerging by the use 
      of such computer model in the Human Genome property rights. The author will argue
      that the Open Source is the best business model, as it is able to balance
      business and human rights perspectives.
FAU - Marturano, Antonio
AU  - Marturano A
AD  - Faculty of Economics, Sacred Heart Catholic University of Rome, Rome, Italy.
LA  - eng
PT  - Journal Article
PL  - Spain
TA  - Rev Derecho Genoma Hum
JT  - Revista de derecho y genoma humano = Law and the human genome review
JID - 101558644
SB  - IM
MH  - Computers
MH  - Databases, Genetic
MH  - Human Genome Project/*ethics
MH  - Humans
EDAT- 2011/07/01 00:00
MHDA- 2012/10/26 06:00
CRDT- 2012/09/19 06:00
PHST- 2012/09/19 06:00 [entrez]
PHST- 2011/07/01 00:00 [pubmed]
PHST- 2012/10/26 06:00 [medline]
PST - ppublish
SO  - Rev Derecho Genoma Hum. 2011 Jul-Dec;(35):225-38.


PMID- 22984753
OWN - NLM
STAT- MEDLINE
DCOM- 20121025
LR  - 20161021
IS  - 1134-7198 (Print)
IS  - 1134-7198 (Linking)
IP  - 35
DP  - 2011 Jul-Dec
TI  - [Decision of the Court of Justice of the European Union on embryonic stem cell
      patents. On a legal report on patents: the concept and dignity of the human
      embryo].
PG  - 145-80
AB  - The Advocate General of the European Court of Justice's opinion on the
      patentability of embryo pluripotent stem cells according to the 98/44/CE
      Directive (Art. 6.2.c) is analyzed. Scientific, ethical and legal considerations 
      on human embryos and stem cells are included.
FAU - Lacadena, Juan-Ramon
AU  - Lacadena JR
AD  - Universidad Complutense de Madrid, Madrid, Espana. jrlgbucm@bio.ucm.es
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Sentencia del Tribunal de Justicia de la Union Europea sobre las patentes de
      celulas troncales embrionarias. A proposito de un informe juridico sobre
      patentes: el concepto y dignidad del embrion humano.
PL  - Spain
TA  - Rev Derecho Genoma Hum
JT  - Revista de derecho y genoma humano = Law and the human genome review
JID - 101558644
SB  - IM
MH  - *Embryo, Mammalian
MH  - *Embryonic Stem Cells
MH  - European Union
MH  - Humans
MH  - Patents as Topic/*ethics/*legislation & jurisprudence
MH  - *Personhood
EDAT- 2011/07/01 00:00
MHDA- 2012/10/26 06:00
CRDT- 2012/09/19 06:00
PHST- 2012/09/19 06:00 [entrez]
PHST- 2011/07/01 00:00 [pubmed]
PHST- 2012/10/26 06:00 [medline]
PST - ppublish
SO  - Rev Derecho Genoma Hum. 2011 Jul-Dec;(35):145-80.


PMID- 22984752
OWN - NLM
STAT- MEDLINE
DCOM- 20121025
LR  - 20161021
IS  - 1134-7198 (Print)
IS  - 1134-7198 (Linking)
IP  - 35
DP  - 2011 Jul-Dec
TI  - [Rare diseases: specific ethical and legal aspects of genetic counseling and
      screening].
PG  - 115-41
AB  - This article analyses the specific rights of patients with rare diseases from a
      dual perspective. On the one hand, they concern a new generation of patients'
      rights that arise once the consolidation of basic rights has occurred,
      fundamentally after the application of Law 41/2002 (on Regulating Patient
      Autonomy and Rights and Obligations in the Field of Health Documentation and
      Information) and its development by the autonomous communities. On the other
      hand, the fundamental question raises a serious issue related to these patients, 
      which involves the principles of equality, equity, non-discrimination and
      solidarity. This is aimed at promoting legislative measures to protect patients' 
      equality of access to health and social services, with the ultimate aim of
      improving their quality of life. The author has given special relevance in his
      study to the treatment of rare diseases that are genetic in origin, and to the
      importance of adequate genetic counseling.
FAU - Sanchez-Caro, Javier
AU  - Sanchez-Caro J
AD  - Consejeria de Sanidad, Comunidad de Madrid, Madrid, Espana.
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Las enfermedades raras: aspectos eticos y juridicos especificos sobre el consejo 
      y el cribado geneticos.
PL  - Spain
TA  - Rev Derecho Genoma Hum
JT  - Revista de derecho y genoma humano = Law and the human genome review
JID - 101558644
SB  - IM
MH  - Genetic Counseling/*ethics/*legislation & jurisprudence
MH  - Genetic Testing/*ethics/*legislation & jurisprudence
MH  - Humans
MH  - Patient Rights
MH  - *Rare Diseases/diagnosis/prevention & control
EDAT- 2011/07/01 00:00
MHDA- 2012/10/26 06:00
CRDT- 2012/09/19 06:00
PHST- 2012/09/19 06:00 [entrez]
PHST- 2011/07/01 00:00 [pubmed]
PHST- 2012/10/26 06:00 [medline]
PST - ppublish
SO  - Rev Derecho Genoma Hum. 2011 Jul-Dec;(35):115-41.


PMID- 22984750
OWN - NLM
STAT- MEDLINE
DCOM- 20121025
LR  - 20161021
IS  - 1134-7198 (Print)
IS  - 1134-7198 (Linking)
IP  - 35
DP  - 2011 Jul-Dec
TI  - [Contributions for a statute of parts separated from the body].
PG  - 67-100
AB  - In this article the author reflects on the ethical and legal implications arising
      from the treatment that should be conferred on the separate parts of the human
      body. Thus, the status of the body is changing so rapidly, due to the new
      developments in biotechnology, that raises unprecedented dilemmas for the Law.
      Also noteworthy the relevant issues brought by the incessant progress of
      biomedical science, claiming regulations consistent with its implications in
      various fields. The following issues will be highlighted by the author: the
      achievements in the fields of molecular biology and genetics, the proliferation
      and diversification of biobanks, and the commercialization and patenting of
      genes, gene sequences and other biological materials, which generates a series of
      ethical and legal problems.
FAU - Dario Bergel, Salvador
AU  - Dario Bergel S
AD  - Facultad de Derecho, Universidad de Buenos Aires, Buenos Aires, Argentina.
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Aportes para un estatuto de las partes separadas del cuerpo.
PL  - Spain
TA  - Rev Derecho Genoma Hum
JT  - Revista de derecho y genoma humano = Law and the human genome review
JID - 101558644
SB  - IM
MH  - *Bioethical Issues
MH  - Genetic Privacy/ethics
MH  - *Human Body
MH  - Humans
MH  - Tissue Banks/*ethics/legislation & jurisprudence
EDAT- 2011/07/01 00:00
MHDA- 2012/10/26 06:00
CRDT- 2012/09/19 06:00
PHST- 2012/09/19 06:00 [entrez]
PHST- 2011/07/01 00:00 [pubmed]
PHST- 2012/10/26 06:00 [medline]
PST - ppublish
SO  - Rev Derecho Genoma Hum. 2011 Jul-Dec;(35):67-100.


PMID- 22977570
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1792-0981 (Print)
IS  - 1792-0981 (Linking)
VI  - 2
IP  - 4
DP  - 2011 Jul
TI  - Study of DNA methylation patterns of imprinted genes in children born after
      assisted reproductive technologies reveals no imprinting errors: A pilot study.
PG  - 751-755
AB  - Assisted reproductive technology (ART) including in vitro fertilization (IVF) and
      intracytoplasmic sperm injection (ICSI) have been shown to be associated with
      abnormal genomic imprinting, thus increasing the incidence of imprinting
      disorders such as Beckwith-Wiedemann syndrome (BWS) and Angelman syndrome (AS) in
      ART-conceived children. Furthermore, a recent study described abnormal DNA
      methylation in clinically normal children conceived by ART. However, data from
      different studies are conflicting or inconclusive. This study examined DNA
      methylation patterns of multiple imprinted genes in children born after ART to
      primarily evaluate the impact of ART on genomic imprinting. A total of 101
      newborns conceived by ART (40 ICSI and 61 IVF) and 60 naturally conceived
      newborns were involved in our study. After obtaining the approval of the
      Institutional Ethics Committee, umbilical cord blood was collected from each
      infant. Genomic DNA was isolated from each blood sample and treated using sodium 
      bisulfite. Subsequently, using methylation-specific PCR (MS-PCR), we analyzed six
      differentially methylated regions (DMRs) including KvDMR1, SNRPN, MEST, MEG3,
      TNDM and XIST. Meanwhile, information regarding twin pregnancies, gestational
      age, and birth weight of the neonates was documented. None of the cases presented
      with phenotypic abnormalities. Children conceived by ART were more likely to have
      low birth weight and to be born before term, compared with children conceived
      spontaneously. However, 7 months to 3 years of clinical follow-up showed that
      none of the children had clinical symptoms of any imprinting diseases.
      Furthermore, the MS-PCR results showed that all 161 children had normal DNA
      methylation patterns at six DMRs despite the different mode of conception. Our
      data did not indicate a higher risk of DNA-methylation defects in children born
      after ART. However, further studies using quantitative methods are needed to
      confirm these results.
FAU - Zheng, Hai-Yan
AU  - Zheng HY
AD  - Center for Reproductive Medicine, Department of Obstetrics and Gynecology,
      Nanfang Hospital, and.
FAU - Shi, Xiao-Yun
AU  - Shi XY
FAU - Wang, LE-LE
AU  - Wang LL
FAU - Wu, Ya-Qin
AU  - Wu YQ
FAU - Chen, Shi-Ling
AU  - Chen SL
FAU - Zhang, Lin
AU  - Zhang L
LA  - eng
PT  - Journal Article
DEP - 20110429
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC3440701
EDAT- 2011/07/01 00:00
MHDA- 2011/07/01 00:01
CRDT- 2012/09/15 06:00
PHST- 2011/02/25 00:00 [received]
PHST- 2011/04/26 00:00 [accepted]
PHST- 2012/09/15 06:00 [entrez]
PHST- 2011/07/01 00:00 [pubmed]
PHST- 2011/07/01 00:01 [medline]
AID - 10.3892/etm.2011.261 [doi]
AID - etm-02-04-0751 [pii]
PST - ppublish
SO  - Exp Ther Med. 2011 Jul;2(4):751-755. doi: 10.3892/etm.2011.261. Epub 2011 Apr 29.


PMID- 21714117
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20151119
IS  - 1932-8494 (Electronic)
IS  - 1932-8486 (Linking)
VI  - 294
IP  - 8
DP  - 2011 Aug
TI  - Extrahepatic and intrahepatic human portal interstitial Cajal cells.
PG  - 1382-92
LID - 10.1002/ar.21441 [doi]
AB  - Portal interstitial cells of Cajal (PICCs), acting as vascular pacemakers, were
      previously only identified in nonhumans. Moreover, there is no evidence available
      about the presence of such cells within the liver. The objective of the study is 
      to evaluate whether or not PICCs are identifiable in humans and, if they are,
      whether or not they are following the scaffold of portal vein (PV) branches
      within the liver. We obtained extrahepatic PVs and liver samples from six adult
      human cadavers, negative for liver disease, in accordance with ethical rules.
      They were stained with hematoxylin-eosin (HE) and Giemsa, and then we performed
      immunohistochemistry on formalin-fixed paraffin-embedded specimens for
      CD117/c-kit, a marker of the Cajal's cells. Immune labeling was also performed
      for S-100 protein, desmin, glial fibrillary acidic protein (GFAP),
      neurofilaments, alpha-smooth muscle actin (alpha-SMA), and CD34. c-kit-Positive
      PICCs were identified within the extrahepatic PV, in portal spaces, and septa. On
      adjacent sections, these PICCs were negative for all the other antibodies used.
      In conclusion, our study confirms the presence of extrahepatic PICCs on humans,
      which may act as a possible intrinsic pacemaker in the human PV. However, the
      intrahepatic PICCs, which were evidenced here for the first time, are in need for
      further experimental studies to evaluate their functional role. A promising
      further direction of the study is the PICCs role in the idiopathic portal
      hypertension.
CI  - Copyright (c) 2011 Wiley-Liss, Inc.
FAU - Rusu, M C
AU  - Rusu MC
AD  - Discipline of Anatomy, Faculty of Dental Medicine, "Carol Davila" University of
      Medicine and Pharmacy, Bucharest, Romania. anatomon@gmail.com
FAU - Pop, F
AU  - Pop F
FAU - Hostiuc, S
AU  - Hostiuc S
FAU - Curca, G C
AU  - Curca GC
FAU - Streinu-Cercel, A
AU  - Streinu-Cercel A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110628
PL  - United States
TA  - Anat Rec (Hoboken)
JT  - Anatomical record (Hoboken, N.J. : 2007)
JID - 101292775
RN  - 0 (ACTA2 protein, human)
RN  - 0 (Actins)
RN  - 0 (Antigens, CD34)
RN  - 0 (Biomarkers)
RN  - 0 (Desmin)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Neurofilament Proteins)
RN  - 0 (S100 Proteins)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-kit)
SB  - IM
MH  - Actins/analysis
MH  - Aged
MH  - Antigens, CD34/analysis
MH  - Biomarkers/analysis
MH  - Cadaver
MH  - Desmin/analysis
MH  - Female
MH  - Glial Fibrillary Acidic Protein/analysis
MH  - Humans
MH  - Immunohistochemistry
MH  - *Interstitial Cells of Cajal/chemistry
MH  - Liver/*blood supply
MH  - Male
MH  - Middle Aged
MH  - Neurofilament Proteins/analysis
MH  - Portal Vein/chemistry/*cytology
MH  - Proto-Oncogene Proteins c-kit/analysis
MH  - S100 Proteins/analysis
MH  - Staining and Labeling
EDAT- 2011/06/30 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/06/30 06:00
PHST- 2010/11/13 00:00 [received]
PHST- 2011/05/16 00:00 [accepted]
PHST- 2011/06/30 06:00 [entrez]
PHST- 2011/06/30 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1002/ar.21441 [doi]
PST - ppublish
SO  - Anat Rec (Hoboken). 2011 Aug;294(8):1382-92. doi: 10.1002/ar.21441. Epub 2011 Jun
      28.


PMID- 21713582
OWN - NLM
STAT- MEDLINE
DCOM- 20131126
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 1
DP  - 2013 Mar
TI  - Technology, recommendation and design: on being a 'paternalistic' philosopher.
PG  - 27-42
LID - 10.1007/s11948-011-9288-9 [doi]
AB  - Philosophers have talked to each other about moral issues concerning technology, 
      but few of them have talked about issues of technology and the good life, and
      even fewer have talked about technology and the good life with the public in the 
      form of recommendation. In effect, recommendations for various technologies are
      often left to technologists and gurus. Given the potential benefits of informing 
      the public on their impacts on the good life, however, this is a curious state of
      affairs. In the present paper, I will examine why philosophers are seemingly
      reluctant to offer recommendations to the public. While there are many reasons
      for philosophers to refrain from offering recommendations, I shall focus on a
      specific normative reason. More specifically, it appears that, according to a
      particular definition, offering recommendations can be viewed as paternalistic,
      and therefore is prima facie wrong to do so. I will provide an argument to show
      that the worry about paternalism is unfounded, because a form of paternalism
      engendered by technology is inevitable. Given the inevitability of paternalism, I
      note that philosophers should accept the duty to offer recommendations to the
      public. I will then briefly turn to design ethics, which has reconceptualised the
      role of philosophers and, in my mind, fitted well with the inevitability of
      paternalism. Finally, I shall argue that design ethics has to be supplemented by 
      the practice of recommendation if it is to sustain its objective.
FAU - Wong, Pak-Hang
AU  - Wong PH
AD  - Department of Philosophy, University of Twente, Enschede, The Netherlands.
      p.h.wong@utwente.nl
LA  - eng
PT  - Journal Article
DEP - 20110629
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Decision Making/*ethics
MH  - Guidelines as Topic
MH  - Humans
MH  - *Morals
MH  - Paternalism/*ethics
MH  - *Philosophy
MH  - *Quality of Life
MH  - Technology/*ethics
PMC - PMC3586114
EDAT- 2011/06/30 06:00
MHDA- 2013/12/16 06:00
CRDT- 2011/06/30 06:00
PHST- 2011/04/17 00:00 [received]
PHST- 2011/06/16 00:00 [accepted]
PHST- 2011/06/30 06:00 [entrez]
PHST- 2011/06/30 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1007/s11948-011-9288-9 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Mar;19(1):27-42. doi: 10.1007/s11948-011-9288-9. Epub 2011
      Jun 29.


PMID- 21712931
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 0974-598X (Electronic)
IS  - 0970-2113 (Linking)
VI  - 28
IP  - 2
DP  - 2011 Apr
TI  - Ethics in writing: Learning to stay away from plagiarism and scientific
      misconduct.
PG  - 148-50
LID - 10.4103/0970-2113.80337 [doi]
AB  - Fraudulent data and plagiarized text may corrupt scientific medical literature
      and ultimately harm patients. By prescribing erroneous treatment to an
      individual, only single patient is affected; but by presenting incorrect data or 
      transcripts, the whole scientific medical universe is affected. Although both
      scenarios are highly undesirable, one can assume the magnitude of the effect of
      latter. Writers of scientific medical literature have been found to be involved
      in plagiarism and other publication misconducts from time to time irrespective of
      social, economic and geographic structure. The reason of such behavior is not
      usually obvious. Easy availability of personal computers has led to widespread
      dissemination of medical literature. As a result, young scientists are now
      publishing their research more frequently and efficiently. At the same time, this
      has increased the tendency to submit hurriedly prepared, poorly drafted and even 
      illegitimate publications. Use of some amount of copy-paste followed by
      modifications during preparation of a manuscript seems to be common. Therefore,
      the researchers, especially postgraduate students, should be educated
      continuously about ethical medical writing.
FAU - Sharma, Bharat Bhushan
AU  - Sharma BB
AD  - Division of Allergy and Pulmonary Medicine, Department of Medicine, SMS Medical
      College, Jaipur, India.
FAU - Singh, Virendra
AU  - Singh V
LA  - eng
PT  - Journal Article
PL  - India
TA  - Lung India
JT  - Lung India : official organ of Indian Chest Society
JID - 8405380
PMC - PMC3109843
OTO - NOTNLM
OT  - Ethics
OT  - plagiarism
OT  - research
OT  - scientific misconduct
OT  - writing
EDAT- 2011/06/30 06:00
MHDA- 2011/06/30 06:01
CRDT- 2011/06/30 06:00
PHST- 2011/06/30 06:00 [entrez]
PHST- 2011/06/30 06:00 [pubmed]
PHST- 2011/06/30 06:01 [medline]
AID - 10.4103/0970-2113.80337 [doi]
AID - LI-28-148 [pii]
PST - ppublish
SO  - Lung India. 2011 Apr;28(2):148-50. doi: 10.4103/0970-2113.80337.


PMID- 21712311
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20181023
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 342
DP  - 2011 Jun 28
TI  - Ethics should trump science in Fukushima.
PG  - d3853
LID - 10.1136/bmj.d3853 [doi]
LID - bmj.d3853 [pii]
FAU - Ono, Masahiro
AU  - Ono M
LA  - eng
PT  - Letter
DEP - 20110628
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
SB  - IM
MH  - Cohort Studies
MH  - *Ethics, Medical
MH  - Japan
MH  - *Radiation, Ionizing
EDAT- 2011/06/30 06:00
MHDA- 2011/11/09 06:00
CRDT- 2011/06/30 06:00
PHST- 2011/06/30 06:00 [entrez]
PHST- 2011/06/30 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - 10.1136/bmj.d3853 [doi]
PST - epublish
SO  - BMJ. 2011 Jun 28;342:d3853. doi: 10.1136/bmj.d3853.


PMID- 21711448
OWN - NLM
STAT- MEDLINE
DCOM- 20111031
LR  - 20111206
IS  - 1600-6143 (Electronic)
IS  - 1600-6135 (Linking)
VI  - 11
IP  - 7
DP  - 2011 Jul
TI  - Derivation of the uncontrolled donation after circulatory determination of death 
      protocol for New York city.
PG  - 1417-26
LID - 10.1111/j.1600-6143.2011.03582.x [doi]
AB  - Evidence from Europe suggests establishing out-of-hospital, uncontrolled donation
      after circulatory determination of death (UDCDD) protocols has potential to
      substantially increase organ availability. The study objective was to derive an
      out-of-hospital UDCDD protocol that would be acceptable to New York City (NYC)
      residents. Participatory action research and the SEED-SCALE process for social
      change guided protocol development in NYC from July 2007 to September 2010. A
      coalition of government officials, subject experts and communities necessary to
      achieve support was formed. Authorized NY State and NYC government officials and 
      their legal representatives collaboratively investigated how the program could be
      implemented under current law and regulations. Community stakeholders (secular
      and religious organizations) were engaged in town hall style meetings.
      Ethnographic data (meeting minutes, field notes, quantitative surveys) were
      collected and posted in a collaborative internet environment. Data were analyzed 
      using an iterative coding scheme to discern themes, theoretical constructs and a 
      summary narrative to guide protocol development. A clinically appropriate,
      ethically sound UDCDD protocol for out-of-hospital settings has been derived.
      This program is likely to be accepted by NYC residents since the protocol was
      derived through partnership with government officials, subject experts and
      community participants.
CI  - 2011 The American Society of Transplantation and the American Society of
      Transplant Surgeons.
FAU - Wall, S P
AU  - Wall SP
AD  - Bellevue Hospital Center, New York, NY, USA.
FAU - Kaufman, B J
AU  - Kaufman BJ
FAU - Gilbert, A J
AU  - Gilbert AJ
FAU - Yushkov, Y
AU  - Yushkov Y
FAU - Goldstein, M
AU  - Goldstein M
FAU - Rivera, J E
AU  - Rivera JE
FAU - O'Hara, D
AU  - O'Hara D
FAU - Lerner, H
AU  - Lerner H
FAU - Sabeta, M
AU  - Sabeta M
FAU - Torres, M
AU  - Torres M
FAU - Smith, C L
AU  - Smith CL
FAU - Hedrington, Z
AU  - Hedrington Z
FAU - Selck, F
AU  - Selck F
FAU - Munjal, K G
AU  - Munjal KG
FAU - Machado, M
AU  - Machado M
FAU - Montella, S
AU  - Montella S
FAU - Pressman, M
AU  - Pressman M
FAU - Teperman, L W
AU  - Teperman LW
FAU - Dubler, N N
AU  - Dubler NN
FAU - Goldfrank, L R
AU  - Goldfrank LR
CN  - NYC UDCDD Study Group
LA  - eng
GR  - R38OT08761/OT/OSTLTS CDC HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110628
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
SB  - IM
CIN - Am J Transplant. 2011 Jul;11(7):1351-2. PMID: 21668641
MH  - Community-Based Participatory Research
MH  - *Death
MH  - Humans
MH  - Informed Consent
MH  - New York City
MH  - Out-of-Hospital Cardiac Arrest
MH  - Tissue and Organ Procurement/*legislation & jurisprudence/methods
MH  - Warm Ischemia
IR  - Dong C
FIR - Dong, Chaoyan
IR  - Goldfrank LR
FIR - Goldfrank, Lewis R
IR  - Montella S
FIR - Montella, Susan
IR  - Wall SP
FIR - Wall, Stephen P
IR  - Meyers C
FIR - Meyers, Chad
IR  - Machado M
FIR - Machado, Marion
IR  - Pressman M
FIR - Pressman, Marcy
IR  - Munjal K
FIR - Munjal, Kevin
IR  - Kaufman BJ
FIR - Kaufman, Bradley J
IR  - Matallana L
FIR - Matallana, Luis
IR  - Dubler NN
FIR - Dubler, Nancy N
IR  - Goldstein MJ
FIR - Goldstein, Michael J
IR  - Gonder CJ
FIR - Gonder, Charles J
IR  - Grossman EB
FIR - Grossman, Eric B
IR  - Hedrington Z
FIR - Hedrington, Ziph
IR  - Lerner H
FIR - Lerner, Harvey
IR  - O'Hara D
FIR - O'Hara, David
IR  - Rivera JE
FIR - Rivera, Julia E
IR  - Sabeta ME
FIR - Sabeta, Maria E
IR  - Selck F
FIR - Selck, Fred
IR  - Smith CL
FIR - Smith, Christopher L
IR  - Torres M
FIR - Torres, Maria
IR  - Yushkov Y
FIR - Yushkov, Yuriy
IR  - Gilbert AJ
FIR - Gilbert, Alexander J
IR  - Teperman LW
FIR - Teperman, Lewis W
EDAT- 2011/06/30 06:00
MHDA- 2011/11/01 06:00
CRDT- 2011/06/30 06:00
PHST- 2011/06/30 06:00 [entrez]
PHST- 2011/06/30 06:00 [pubmed]
PHST- 2011/11/01 06:00 [medline]
AID - 10.1111/j.1600-6143.2011.03582.x [doi]
PST - ppublish
SO  - Am J Transplant. 2011 Jul;11(7):1417-26. doi: 10.1111/j.1600-6143.2011.03582.x.
      Epub 2011 Jun 28.


PMID- 21711192
OWN - NLM
STAT- MEDLINE
DCOM- 20120319
LR  - 20110629
IS  - 1465-3338 (Electronic)
IS  - 0307-9457 (Linking)
VI  - 40
IP  - 3
DP  - 2011 Jun
TI  - Experimental infection of domestic canaries (Serinus canaria domestica) with
      Mycoplasma gallisepticum: a new model system for a wildlife disease.
PG  - 321-7
LID - 10.1080/03079457.2011.571660 [doi]
AB  - The ethical and logistical challenges inherent in experimental infections of
      wild-caught animals present a key limitation to the study of wildlife diseases.
      Here we characterize a potentially useful domestic model for a wildlife disease
      that has been of particular interest in recent decades; that is, infection of
      North American house finches (Carpodacus mexicanus) with Mycoplasma
      gallisepticum, more commonly known as a worldwide poultry pathogen. Seven
      domestic canaries (Serinus canaria domestica) were infected experimentally with
      M. gallisepticum alongside two wild-caught house finches (C. mexicanus) and the
      resulting clinical disease, pathogen load, serology and pathology were compared. 
      Although rates of morbidity were higher in domestic canaries in response to M.
      gallisepticum infection, no significant differences were detected between the two
      species in the four measures of infection and disease studied. Our results
      support previous field and experimental studies that have documented universal
      susceptibility to M. gallisepticum infection in the avian family Fringillidae,
      which includes domestic canaries. Our results also indicate that domestic
      canaries may serve as a potentially useful model system for the experimental
      study of M. gallisepticum infection in songbirds.
FAU - Hawley, Dana M
AU  - Hawley DM
AD  - Department of Biology, Virginia Tech, Blacksburg, VA 24061, USA. hawleyd@vt.edu
FAU - Grodio, Jessica
AU  - Grodio J
FAU - Frasca, Salvatore
AU  - Frasca S
FAU - Kirkpatrick, Laila
AU  - Kirkpatrick L
FAU - Ley, David H
AU  - Ley DH
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - Avian Pathol
JT  - Avian pathology : journal of the W.V.P.A
JID - 8210638
SB  - IM
MH  - Animals
MH  - Animals, Wild
MH  - Bird Diseases/*microbiology/pathology
MH  - *Canaries
MH  - Mycoplasma Infections/microbiology/pathology/*veterinary
MH  - *Mycoplasma gallisepticum
EDAT- 2011/06/30 06:00
MHDA- 2012/03/20 06:00
CRDT- 2011/06/30 06:00
PHST- 2011/06/30 06:00 [entrez]
PHST- 2011/06/30 06:00 [pubmed]
PHST- 2012/03/20 06:00 [medline]
AID - 10.1080/03079457.2011.571660 [doi]
PST - ppublish
SO  - Avian Pathol. 2011 Jun;40(3):321-7. doi: 10.1080/03079457.2011.571660.


PMID- 21711126
OWN - NLM
STAT- MEDLINE
DCOM- 20111219
LR  - 20211020
IS  - 1557-7740 (Electronic)
IS  - 1557-7740 (Linking)
VI  - 14
IP  - 8
DP  - 2011 Aug
TI  - Posthumous reproduction and palliative care.
PG  - 895-8
LID - 10.1089/jpm.2011.0102 [doi]
AB  - Posthumous reproduction is an issue fraught with legal, ethical, religious, and
      moral debate. The involvement of the hospice and palliative care community in
      this debate may be peripheral due to the fact that other health care
      professionals would be actually delivering the services. However, the hospice and
      palliative care community are more likely to treat patients considering
      posthumous reproduction as they near the end of their lives. This article
      provides the hospice and palliative care community with a review of the medical, 
      ethical, and legal considerations associated with posthumous reproduction. Having
      knowledge of these issues, and a list of available resources, will be useful if
      hospice and palliative care staff find themselves facing a patient or family that
      is considering posthumous reproduction.
FAU - Knapp, Caprice
AU  - Knapp C
AD  - Department of Health Outcomes and Policy, University of Florida, Gainesville,
      Florida 32610, USA. cak@ichp.ufl.edu
FAU - Quinn, Gwendolyn
AU  - Quinn G
FAU - Bower, Bethanne
AU  - Bower B
FAU - Zoloth, Laurie
AU  - Zoloth L
LA  - eng
GR  - 1 UL1 DE019587/DE/NIDCR NIH HHS/United States
PT  - Journal Article
PT  - Legal Case
PT  - Research Support, N.I.H., Extramural
DEP - 20110628
PL  - United States
TA  - J Palliat Med
JT  - Journal of palliative medicine
JID - 9808462
SB  - IM
MH  - Humans
MH  - *Palliative Care
MH  - *Posthumous Conception/ethics/legislation & jurisprudence
MH  - Reproductive Techniques, Assisted
PMC - PMC3146744
EDAT- 2011/06/30 06:00
MHDA- 2011/12/20 06:00
CRDT- 2011/06/30 06:00
PHST- 2011/06/30 06:00 [entrez]
PHST- 2011/06/30 06:00 [pubmed]
PHST- 2011/12/20 06:00 [medline]
AID - 10.1089/jpm.2011.0102 [doi]
PST - ppublish
SO  - J Palliat Med. 2011 Aug;14(8):895-8. doi: 10.1089/jpm.2011.0102. Epub 2011 Jun
      28.


PMID- 21710960
OWN - NLM
STAT- MEDLINE
DCOM- 20111213
LR  - 20211020
IS  - 0148-4834 (Print)
IS  - 0148-4834 (Linking)
VI  - 50
IP  - 10
DP  - 2011 Oct
TI  - Learning health equity frameworks within a community of scholars.
PG  - 569-74
LID - 10.3928/01484834-20110630-05 [doi]
AB  - Scholars in nursing science have long espoused the concept of health equity
      without specifically using the term or dialoguing about the social determinants
      of health and social justice. This article describes the development,
      implementation, and evaluation of a doctoral and postdoctoral seminar collective 
      entitled "Health Equity: Conceptual, Linguistic, Methodological, and Ethical
      Issues." The course enabled scholars-in-training to consider the construct and
      its nuances and frame a personal philosophy of health equity. An example of how a
      group of emerging scholars can engage in the important, but difficult, discourse 
      related to health equity is provided. The collective provided a forum for debate,
      intellectual growth, and increased insight for students and faculty. The lessons 
      learned by all participants have the potential to enrich doctoral and
      postdoctoral scientific training in nursing science and may serve as a model for 
      other research training programs in the health sciences.
CI  - Copyright 2011, SLACK Incorporated.
FAU - Alexander, Kamila A
AU  - Alexander KA
AD  - University of Pennsylvania School of Nursing, Philadelphia, PA, USA.
      kamilaa@nursing.upenn.edu
FAU - Dovydaitis, Tiffany
AU  - Dovydaitis T
FAU - Beacham, Barbara
AU  - Beacham B
FAU - Bohinski, Julia M
AU  - Bohinski JM
FAU - Brawner, Bridgette M
AU  - Brawner BM
FAU - Clements, Carla P
AU  - Clements CP
FAU - Everett, Janine S
AU  - Everett JS
FAU - Gomes, Melissa M
AU  - Gomes MM
FAU - Harner, Holly
AU  - Harner H
FAU - McDonald, Catherine C
AU  - McDonald CC
FAU - Pinkston, Esther
AU  - Pinkston E
FAU - Sommers, Marilyn S
AU  - Sommers MS
LA  - eng
GR  - F31 NR011107/NR/NINR NIH HHS/United States
GR  - F31NR011524/NR/NINR NIH HHS/United States
GR  - F31 NR011524-02/NR/NINR NIH HHS/United States
GR  - F31 NR011106-03/NR/NINR NIH HHS/United States
GR  - F31 NR011106/NR/NINR NIH HHS/United States
GR  - F31NR011107/NR/NINR NIH HHS/United States
GR  - R01 NR005352/NR/NINR NIH HHS/United States
GR  - F31 NR011107-02/NR/NINR NIH HHS/United States
GR  - T32 NR007100-14/NR/NINR NIH HHS/United States
GR  - T32NR007100/NR/NINR NIH HHS/United States
GR  - 2R01NR005352/NR/NINR NIH HHS/United States
GR  - T32 NR007100/NR/NINR NIH HHS/United States
GR  - F31NR011106/NR/NINR NIH HHS/United States
GR  - F31 NR011524/NR/NINR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110630
PL  - United States
TA  - J Nurs Educ
JT  - The Journal of nursing education
JID - 7705432
SB  - IM
MH  - *Curriculum
MH  - *Education, Nursing, Graduate
MH  - *Health Status Disparities
MH  - *Healthcare Disparities
MH  - Humans
MH  - Program Development
MH  - United States
PMC - PMC3242005
MID - NIHMS333950
EDAT- 2011/06/30 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/06/30 06:00
PHST- 2010/10/30 00:00 [received]
PHST- 2011/05/18 00:00 [accepted]
PHST- 2011/06/30 06:00 [entrez]
PHST- 2011/06/30 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 10.3928/01484834-20110630-05 [doi]
PST - ppublish
SO  - J Nurs Educ. 2011 Oct;50(10):569-74. doi: 10.3928/01484834-20110630-05. Epub 2011
      Jun 30.


PMID- 21710432
OWN - NLM
STAT- MEDLINE
DCOM- 20111216
LR  - 20110628
IS  - 1696-3547 (Electronic)
IS  - 0214-6282 (Linking)
VI  - 55
IP  - 3
DP  - 2011
TI  - The biopolitics of frozen embryos.
PG  - 243-7
LID - 10.1387/ijdb.103281mm [doi]
AB  - The unresolved debate about frozen embryos has left open the discussion on "what 
      to do with them". There are only three ways to deal with frozen embryos: 1) to
      leave them frozen indefinitely; 2) to defrost and discard them and 3) to use them
      for research. In this paper, we suggest that the application of current
      scientific knowledge, instead of inappropriately referring to ethical principles 
      or to the concept of person, could help with the decision about what to do with
      hundreds of thousands of frozen embryos, thus bringing the sensitive debate on
      bioethical issues to shared practical solutions. We face a new individual only
      when a new functional copy of his genome is formed. In both natural and
      artificial animal and plant reproduction, this principle applies. This status
      occurs in humans at the 4-8 cell stage. Acknowledgement of this factual datum
      would allow advocates of all religious and ideological beliefs to defend their
      principles and to realign their positions to a setting within the boundaries of
      current scientific knowledge.
FAU - Monti, Manuela
AU  - Monti M
AD  - Scientific Unit, San Matteo Foundation for Research, Hospitalization and Health
      Care, Pavia, Italy. m.monti@smatteo.pv.it
FAU - Redi, Carlo A
AU  - Redi CA
LA  - eng
PT  - Journal Article
PL  - Spain
TA  - Int J Dev Biol
JT  - The International journal of developmental biology
JID - 8917470
SB  - IM
MH  - Beginning of Human Life/ethics
MH  - Cryopreservation/*ethics
MH  - *Embryo, Mammalian
MH  - Genome
MH  - Humans
MH  - Personhood
MH  - *Politics
MH  - Religion and Science
MH  - Stem Cell Research/ethics
EDAT- 2011/06/29 06:00
MHDA- 2011/12/17 06:00
CRDT- 2011/06/29 06:00
PHST- 2011/06/29 06:00 [entrez]
PHST- 2011/06/29 06:00 [pubmed]
PHST- 2011/12/17 06:00 [medline]
AID - 103281mm [pii]
AID - 10.1387/ijdb.103281mm [doi]
PST - ppublish
SO  - Int J Dev Biol. 2011;55(3):243-7. doi: 10.1387/ijdb.103281mm.


PMID- 21710376
OWN - NLM
STAT- MEDLINE
DCOM- 20120209
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 17
IP  - 2
DP  - 2011 Jun
TI  - Aesthetics and ethics in engineering: insights from Polanyi.
PG  - 233-43
LID - 10.1007/s11948-009-9188-4 [doi]
AB  - Polanyi insisted that scientific knowledge was intensely personal in nature,
      though held with universal intent. His insights regarding the personal values of 
      beauty and morality in science are first enunciated. These are then explored for 
      their relevance to engineering. It is shown that the practice of engineering is
      also governed by aesthetics and ethics. For example, Polanyi's three spheres of
      morality in science--that of the individual scientist, the scientific community
      and the wider society--has parallel entities in engineering. The existence of
      shared values in engineering is also demonstrated, in aesthetics through an
      example that shows convergence of practitioner opinion to solutions that
      represent accepted models of aesthetics; and in ethics through the recognition
      that many professional engineering institutions hold that the safety of the
      public supersedes the interests of the client. Such professional consensus can be
      seen as justification for studying engineering aesthetics and ethics as
      inter-subjective disciplines.
FAU - Dias, Priyan
AU  - Dias P
AD  - Department of Civil Engineering, University of Moratuwa, Moratuwa, Sri Lanka.
      priyan@civil.mrt.ac.lk
LA  - eng
PT  - Biography
PT  - Historical Article
PT  - Journal Article
DEP - 20091122
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Engineering/ethics/history
MH  - *Esthetics/history
MH  - History, 20th Century
MH  - Problem Solving
MH  - Safety/history
MH  - *Science/ethics/history
MH  - *Social Responsibility
MH  - *Social Values/history
PS  - Polanyi M
FPS - Polanyi, Michael
EDAT- 2011/06/29 06:00
MHDA- 2012/02/10 06:00
CRDT- 2011/06/29 06:00
PHST- 2009/09/02 00:00 [received]
PHST- 2009/11/10 00:00 [accepted]
PHST- 2011/06/29 06:00 [entrez]
PHST- 2011/06/29 06:00 [pubmed]
PHST- 2012/02/10 06:00 [medline]
AID - 10.1007/s11948-009-9188-4 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2011 Jun;17(2):233-43. doi: 10.1007/s11948-009-9188-4. Epub 2009 
      Nov 22.


PMID- 21710224
OWN - NLM
STAT- MEDLINE
DCOM- 20120201
LR  - 20211020
IS  - 1573-0980 (Electronic)
IS  - 1386-7415 (Linking)
VI  - 32
IP  - 6
DP  - 2011 Dec
TI  - What is the outcome of applying principlism?
PG  - 375-88
LID - 10.1007/s11017-011-9185-x [doi]
AB  - The four principles approach to bioethics, an approach most associated with the
      work of Tom Beauchamp and James Childress, is supposed to provide a framework for
      reasoning through moral issues in medicine. One might wonder, if one were to
      guide one's thinking by the method suggested by principlism, will one identify
      and perform the objectively morally right action? Will one's decision making be
      justified, and consequently, will the action that flows from that decision itself
      be justified? In this paper, I show that principlism can, and has been,
      characterized in these two different ways. I also argue that when it is
      understood according to the first characterization, the view cannot be put into
      practice. However, when it is understood as an account of justification, there is
      reason to think that it is indeed action-guiding. Given the problems that
      confront the first version of the view, perhaps it is best to understand
      principlism, and biomedical ethical theories generally, not as action-guiding
      theories of right action, but rather, as procedures by which one's decisions and 
      actions in medicine can achieve a reasonable degree of moral justification.
FAU - Hine, Kristen
AU  - Hine K
AD  - Department of Philosophy and Religious Studies, Towson University, Towson, MD
      21252, USA. khine@towson.edu
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Theor Med Bioeth
JT  - Theoretical medicine and bioethics
JID - 9805378
SB  - IM
MH  - Bioethics
MH  - Choice Behavior/ethics
MH  - Decision Making/*ethics
MH  - Ethical Analysis
MH  - *Ethical Theory
MH  - Humans
MH  - Morals
MH  - Philosophy, Medical
MH  - *Principle-Based Ethics
EDAT- 2011/06/29 06:00
MHDA- 2012/02/02 06:00
CRDT- 2011/06/29 06:00
PHST- 2011/06/29 06:00 [entrez]
PHST- 2011/06/29 06:00 [pubmed]
PHST- 2012/02/02 06:00 [medline]
AID - 10.1007/s11017-011-9185-x [doi]
PST - ppublish
SO  - Theor Med Bioeth. 2011 Dec;32(6):375-88. doi: 10.1007/s11017-011-9185-x.


PMID- 21710076
OWN - NLM
STAT- MEDLINE
DCOM- 20110818
LR  - 20190911
IS  - 0080-6234 (Print)
IS  - 0080-6234 (Linking)
VI  - 45
IP  - 3
DP  - 2011 Jun
TI  - [Mental health care today].
PG  - 687-91
LID - S0080-62342011000300020 [pii]
AB  - The objective of this study was to identify the sociodemographic characteristics 
      of caregivers to people who have been discharged from psychiatric
      hospitalization. A quantitative exploratory study was performed at an outpatient 
      clinic of a mental health service. The sample consisted of patients who had been 
      discharged and their caregivers. A questionnaire was used, and the study was
      approved by the local research ethics committee. Of the 48 discharged patients,
      21 had a caregiver. All the identified caregivers were relatives of the patients,
      and their average age was 46.6 years. In 38% of cases, the patient's mother was
      the caregiver. In terms of marital status, 61.9% of the caregivers were married
      or living in common-law relationships, and only one caregiver did not have
      children. The main source of income for 28.6% of the participants was temporary
      keeping eventual jobs. By knowing who is the caregiver of a patient discharged
      from psychiatric hospitalization it is possible to identify the characteristics
      that may help to determine the best treatment and professional support for that
      population.
FAU - Cardoso, Lucilene
AU  - Cardoso L
AD  - Departamento de Enfermagem Psiquiatrica e Ciencias Humanas, Escola de Enfermagem 
      de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brasil.
      lucilene@eerp.usp.br
FAU - Galera, Sueli Aparecida Frari
AU  - Galera SA
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - O cuidado em saude mental na atualidade.
PL  - Brazil
TA  - Rev Esc Enferm USP
JT  - Revista da Escola de Enfermagem da U S P
JID - 0242726
MH  - Adult
MH  - *Caregivers
MH  - Female
MH  - Humans
MH  - Male
MH  - Mental Disorders/*therapy
MH  - Middle Aged
MH  - Prospective Studies
MH  - Young Adult
EDAT- 2011/06/29 06:00
MHDA- 2011/08/19 06:00
CRDT- 2011/06/29 06:00
PHST- 2007/01/27 00:00 [received]
PHST- 2010/09/06 00:00 [accepted]
PHST- 2011/06/29 06:00 [entrez]
PHST- 2011/06/29 06:00 [pubmed]
PHST- 2011/08/19 06:00 [medline]
AID - S0080-62342011000300020 [pii]
AID - 10.1590/s0080-62342011000300020 [doi]
PST - ppublish
SO  - Rev Esc Enferm USP. 2011 Jun;45(3):687-91. doi: 10.1590/s0080-62342011000300020.


PMID- 21710066
OWN - NLM
STAT- MEDLINE
DCOM- 20110818
LR  - 20190911
IS  - 0080-6234 (Print)
IS  - 0080-6234 (Linking)
VI  - 45
IP  - 3
DP  - 2011 Jun
TI  - [Nursing professionals' knowledge about erythropoietin].
PG  - 617-23
LID - S0080-62342011000300010 [pii]
AB  - This study was performed with the objective to evaluate the knowledge that
      nursing professionals have about the process of preserving, preparing and
      administering erythropoietin (EPO). This exploratory, descriptive study used a
      quantitative approach. It was performed at a Dialysis Center, from January to
      March 2009, and consisted on applying a questionnaire to 40 nursing
      professionals. All ethical aspects were taken into consideration. About the
      interaction of EPO with the patients' blood pressure, 87.5% had inadequate
      knowledge; only 32% knew the ideal temperature to preserve the drug, and 52.5%
      believe that it should be removed from the refrigerator about 15 to 30 minutes
      before its administration; intravenous administration was the most reported.
      Among the care before the administration, the most frequent was checking the
      expiration date; 57.5% used exclusive syringe for the administration and 95%
      usually register having administered the drug.
FAU - Barbosa, Islene Victor
AU  - Barbosa IV
AD  - Universidade de Fortaleza, Fortaleza, CE, Brasil.
FAU - Maia, Sayonnara Ferreira
AU  - Maia SF
FAU - Melo, Elizabeth Mesquita
AU  - Melo EM
FAU - Studart, Rita Monica Borges
AU  - Studart RM
FAU - Lima, Francisca Elisangela Teixeira
AU  - Lima FE
FAU - Carvalho, Zuila Maria de Figueiredo
AU  - Carvalho ZM
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Conocimiento de los profesionales de enfermeria sobre la eritropoyetina.
PL  - Brazil
TA  - Rev Esc Enferm USP
JT  - Revista da Escola de Enfermagem da U S P
JID - 0242726
RN  - 11096-26-7 (Erythropoietin)
MH  - *Clinical Competence
MH  - Drug Compounding
MH  - Drug Storage
MH  - Erythropoietin/administration & dosage/*therapeutic use
MH  - *Nursing
EDAT- 2011/06/29 06:00
MHDA- 2011/08/19 06:00
CRDT- 2011/06/29 06:00
PHST- 2010/06/11 00:00 [received]
PHST- 2010/09/21 00:00 [accepted]
PHST- 2011/06/29 06:00 [entrez]
PHST- 2011/06/29 06:00 [pubmed]
PHST- 2011/08/19 06:00 [medline]
AID - S0080-62342011000300010 [pii]
AID - 10.1590/s0080-62342011000300010 [doi]
PST - ppublish
SO  - Rev Esc Enferm USP. 2011 Jun;45(3):617-23. doi: 10.1590/s0080-62342011000300010.


PMID- 21710043
OWN - NLM
STAT- MEDLINE
DCOM- 20111128
LR  - 20191112
IS  - 1809-4546 (Electronic)
IS  - 0100-6991 (Linking)
VI  - 38
IP  - 2
DP  - 2011 Mar-Apr
TI  - [The "ethical" repair of the abdominal wall].
PG  - 83-4
LID - S0100-69912011000200002 [pii]
FAU - Melo, Renato Miranda de
AU  - Melo RM
LA  - por
PT  - Editorial
TT  - O reparo "etico" da parede abdominal.
PL  - Brazil
TA  - Rev Col Bras Cir
JT  - Revista do Colegio Brasileiro de Cirurgioes
JID - 7809515
SB  - IM
MH  - Abdominal Wall/*surgery
MH  - Humans
MH  - Surgical Procedures, Operative/standards
EDAT- 2011/06/29 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/06/29 06:00
PHST- 2011/06/29 06:00 [entrez]
PHST- 2011/06/29 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0100-69912011000200002 [pii]
AID - 10.1590/s0100-69912011000200002 [doi]
PST - ppublish
SO  - Rev Col Bras Cir. 2011 Mar-Apr;38(2):83-4. doi: 10.1590/s0100-69912011000200002.


PMID- 21709971
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20190907
IS  - 1678-4561 (Electronic)
IS  - 1413-8123 (Linking)
VI  - 16
IP  - 6
DP  - 2011 Jun
TI  - [Good governance of publicly-produced health services: ideas for moving forward].
PG  - 2733-42
LID - S1413-81232011000600012 [pii]
AB  - The good performance of publicly-produced health services is of vital importance,
      well beyond the health sector. Taking into account the great complexity of the
      health services in the public sector due both to their public and professional
      nature, we identify seven Gordian Knots as being responsible for the most
      frequent problems of publicly produced health services in Spain and Latin
      America. From the concept of good governance we take its character as a normative
      and ethical benchmark and its potential to renew and invigorate the government of
      the public sector. From comparative analysis of publicly-produced health services
      in the best performing countries, we extract eight characteristics which
      contribute significantly to good performance. A final reflection is on the
      relevance of the importance of offsetting the potential hostility to a reformist 
      impulse of the status-quo with alliances that strengthen public trust and the
      social contract between health professionals and citizens based on the values of 
      public health systems.
FAU - Freire, Jose Manuel
AU  - Freire JM
AD  - Departamento de Salud Internacional, Escuela Nacional de Sanidad, Instituto de
      Salud Carlos III, Ministerio de Ciencia e Innovacion, Madrid, Espana.
      jmfreire@isciii.es
FAU - Repullo, Jose Ramon
AU  - Repullo JR
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - El buen gobierno de los servicios de salud de produccion publica: ideas para
      avanzar.
PL  - Brazil
TA  - Cien Saude Colet
JT  - Ciencia & saude coletiva
JID - 9713483
SB  - IM
MH  - *Health Services Administration/standards
MH  - Public Sector
EDAT- 2011/06/29 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/06/29 06:00
PHST- 2011/02/23 00:00 [received]
PHST- 2011/04/14 00:00 [accepted]
PHST- 2011/06/29 06:00 [entrez]
PHST- 2011/06/29 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - S1413-81232011000600012 [pii]
AID - 10.1590/s1413-81232011000600012 [doi]
PST - ppublish
SO  - Cien Saude Colet. 2011 Jun;16(6):2733-42. doi: 10.1590/s1413-81232011000600012.


PMID- 21709970
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20220330
IS  - 1678-4561 (Electronic)
IS  - 1413-8123 (Linking)
VI  - 16
IP  - 6
DP  - 2011 Jun
TI  - [New professionalism, medical education and healthcare systems].
PG  - 2725-32
LID - S1413-81232011000600011 [pii]
AB  - The scope of this paper is to discuss how so-called "new professionalism" can
      help in how the education of physicians is conducted, by taking into account the 
      effects of globalization both on the situation of health and on the needs of
      health professionals with particular emphasis on European Union countries, which 
      are engaged in a profound process of reform in university education. To achieve
      this, first we present the basic concepts of "new professionalism" and the key
      strategies of current medical education, which is to train physicians capable of 
      dealing with ethical, scientific and professional challenges that are arising at 
      the beginning of this century. The interdependence of reforms in the
      undergraduate, graduate and ongoing training areas is then emphasized. The
      challenges and difficulties to be faced when switching to different stages of
      medical education are then outlined. It was concluded that, notwithstanding
      recent reforms in medical education, their great complexity and the still limited
      availability of contrasting assessments of their results, there are strong
      synergies between the principles and values of the "new professionalism" and the 
      objectives of the reforms.
FAU - Campos, Alberto Infante
AU  - Campos AI
AD  - Departamento de Salud Internacional, Escuela Nacional de Sanidad, Instituto de
      Salud Carlos III, Ministerio de Ciencia e Innovacion, Madrid, Espana.
      ainfante@isciii.es
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Nuevo profesionalismo, educacion medica y sistemas de salud.
PL  - Brazil
TA  - Cien Saude Colet
JT  - Ciencia & saude coletiva
JID - 9713483
SB  - IM
CIN - Cien Saude Colet. 2012 Jan;17(1):273-4; author reply 274. PMID: 22218561
MH  - *Delivery of Health Care
MH  - Education, Medical/*standards
EDAT- 2011/06/29 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/06/29 06:00
PHST- 2011/02/09 00:00 [received]
PHST- 2011/03/30 00:00 [accepted]
PHST- 2011/06/29 06:00 [entrez]
PHST- 2011/06/29 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - S1413-81232011000600011 [pii]
AID - 10.1590/s1413-81232011000600011 [doi]
PST - ppublish
SO  - Cien Saude Colet. 2011 Jun;16(6):2725-32. doi: 10.1590/s1413-81232011000600011.


PMID- 21709454
OWN - NLM
STAT- MEDLINE
DCOM- 20110909
LR  - 20200930
IS  - 1944-7884 (Electronic)
IS  - 1525-4135 (Linking)
VI  - 57
IP  - 2
DP  - 2011 Jun 1
TI  - Human rights, ethics, and the protection of intravenous drug users are much
      improved in China.
PG  - e31-2
LID - 10.1097/QAI.0b013e3182182fda [doi]
FAU - Liu, Feng-Liang
AU  - Liu FL
FAU - Yao, Yong-Gang
AU  - Yao YG
FAU - Li, Hong
AU  - Li H
FAU - Zheng, Yong-Tang
AU  - Zheng YT
LA  - eng
PT  - Letter
PL  - United States
TA  - J Acquir Immune Defic Syndr
JT  - Journal of acquired immune deficiency syndromes (1999)
JID - 100892005
SB  - IM
MH  - China
MH  - *Ethics, Research
MH  - HIV Infections/*epidemiology
MH  - HIV-1/isolation & purification
MH  - Human Rights/*standards
MH  - Humans
MH  - Informed Consent
MH  - Substance Abuse, Intravenous
MH  - Surveys and Questionnaires
EDAT- 2011/06/29 06:00
MHDA- 2011/09/10 06:00
CRDT- 2011/06/29 06:00
PHST- 2011/06/29 06:00 [entrez]
PHST- 2011/06/29 06:00 [pubmed]
PHST- 2011/09/10 06:00 [medline]
AID - 10.1097/QAI.0b013e3182182fda [doi]
AID - 00126334-201106010-00019 [pii]
PST - ppublish
SO  - J Acquir Immune Defic Syndr. 2011 Jun 1;57(2):e31-2. doi:
      10.1097/QAI.0b013e3182182fda.


PMID- 21709453
OWN - NLM
STAT- MEDLINE
DCOM- 20110909
LR  - 20200930
IS  - 1944-7884 (Electronic)
IS  - 1525-4135 (Linking)
VI  - 57
IP  - 2
DP  - 2011 Jun 1
TI  - Human rights abuses, ethics, and the protection of subjects when conducting
      research on intravenous drug users in China.
PG  - e29-31
LID - 10.1097/QAI.0b013e318215de81 [doi]
FAU - Amon, Joseph J
AU  - Amon JJ
LA  - eng
PT  - Comment
PT  - Letter
PL  - United States
TA  - J Acquir Immune Defic Syndr
JT  - Journal of acquired immune deficiency syndromes (1999)
JID - 100892005
SB  - IM
CON - J Acquir Immune Defic Syndr. 2011 Apr;56(4):306-11. PMID: 21107267
MH  - China
MH  - *Ethics, Research
MH  - HIV Infections/*epidemiology/prevention & control
MH  - Human Rights Abuses/*prevention & control
MH  - Humans
MH  - Informed Consent
MH  - Patient Selection
MH  - Substance Abuse, Intravenous/*complications
EDAT- 2011/06/29 06:00
MHDA- 2011/09/10 06:00
CRDT- 2011/06/29 06:00
PHST- 2011/06/29 06:00 [entrez]
PHST- 2011/06/29 06:00 [pubmed]
PHST- 2011/09/10 06:00 [medline]
AID - 10.1097/QAI.0b013e318215de81 [doi]
AID - 00126334-201106010-00018 [pii]
PST - ppublish
SO  - J Acquir Immune Defic Syndr. 2011 Jun 1;57(2):e29-31. doi:
      10.1097/QAI.0b013e318215de81.


PMID- 21709314
OWN - NLM
STAT- MEDLINE
DCOM- 20111014
LR  - 20190513
IS  - 1930-6180 (Electronic)
IS  - 1084-2020 (Linking)
VI  - 52
IP  - 2
DP  - 2011
TI  - IACUC Challenges in Invertebrate Research.
PG  - 213-20
AB  - With billions of individuals and possibly hundreds of thousands of genera,
      invertebrates represent the largest number and greatest diversity of all animals 
      used in research. Although the capacity for nociception is recognized in many
      invertebrate taxa, researchers and IACUC members are challenged by a lack of
      clear understanding of invertebrate welfare and by differing standards of moral
      concern for these taxa. In practice this has led IACUCs to consider invertebrates
      in two major groups: species worthy of increased moral concern approximating that
      shown to vertebrate species (this group includes cephalopods and to some extent
      decapod crustaceans) and all others. This dichotomy has led to differences in how
      invertebrate research is regulated and documented. This article presents two case
      studies illustrating specific concerns in invertebrate research protocols and
      then provides relevant information to address practical IACUC matters related to 
      regulatory and ethical issues, sourcing and record keeping, risk management,
      assessment of pain and nociception in invertebrates, housing and husbandry,
      invasive procedures, veterinary care, and humane endpoints.
FAU - Harvey-Clark, Chris
AU  - Harvey-Clark C
AD  - Animal Care Centre, University of British Columbia, Vancouver, Canada.
      chclark@interchange.ubc.ca
LA  - eng
PT  - Journal Article
PL  - England
TA  - ILAR J
JT  - ILAR journal
JID - 9516416
SB  - IM
MH  - *Animal Care Committees
MH  - *Animal Welfare
MH  - Animals
MH  - *Invertebrates
EDAT- 2011/06/29 06:00
MHDA- 2011/10/15 06:00
CRDT- 2011/06/29 06:00
PHST- 2011/06/29 06:00 [entrez]
PHST- 2011/06/29 06:00 [pubmed]
PHST- 2011/10/15 06:00 [medline]
AID - 10.1093/ilar.52.2.213 [doi]
PST - ppublish
SO  - ILAR J. 2011;52(2):213-20. doi: 10.1093/ilar.52.2.213.


PMID- 21709274
OWN - NLM
STAT- MEDLINE
DCOM- 20110907
LR  - 20211020
IS  - 1460-2105 (Electronic)
IS  - 0027-8874 (Linking)
VI  - 103
IP  - 14
DP  - 2011 Jul 20
TI  - Randomized phase II trials: a long-term investment with promising returns.
PG  - 1093-100
LID - 10.1093/jnci/djr218 [doi]
AB  - Given the multitude of novel anticancer drugs and the limited resources available
      to study them, phase II trials should identify drugs with the highest probability
      of succeeding in subsequent phase III trials. Currently, single-arm phase II
      trial results are interpreted relative to historical control subjects,
      introducing selection bias and confounding that may limit the validity of the
      conclusions. The rate of success (defined as a statistically significant
      difference between arms) in phase III oncology trials is only 40%, suggesting
      that current phase II trials are insufficiently informative. However, simulation 
      studies suggest that randomized phase II trials would have lower error rates and 
      greater predictive power for phase III results. Randomized phase II trials may
      also be more informative than single-arm phase II trials because of the
      hypotheses being tested, the variety of possible endpoints, and the opportunities
      for biomarker discovery. There are a wide variety of randomized phase II designs 
      that can be used, including the randomized discontinuation design, the
      delayed-start design, adaptive (Bayesian) designs, selection designs, and phase
      II/III designs. The barriers to widespread adoption of randomized phase II trials
      include time to completion, sample size considerations, and ethical concerns, but
      none are insurmountable. We conclude that randomized phase II trials are a worthy
      investment considering finite patient and financial resources and should be the
      rule rather than the exception for evaluating novel therapies in oncology.
FAU - Sharma, Manish R
AU  - Sharma MR
AD  - Department of Medicine, University of Chicago, Chicago, IL 60637-1470, USA.
FAU - Stadler, Walter M
AU  - Stadler WM
FAU - Ratain, Mark J
AU  - Ratain MJ
LA  - eng
GR  - T32GM007019/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20110627
PL  - United States
TA  - J Natl Cancer Inst
JT  - Journal of the National Cancer Institute
JID - 7503089
RN  - 0 (Antineoplastic Agents)
SB  - IM
CIN - J Natl Cancer Inst. 2011 Jul 20;103(14):1075-7. PMID: 21709273
MH  - *Antineoplastic Agents/therapeutic use
MH  - Chemotherapy, Adjuvant
MH  - *Clinical Trials, Phase II as Topic/methods/standards
MH  - Clinical Trials, Phase III as Topic
MH  - Confounding Factors, Epidemiologic
MH  - *Endpoint Determination
MH  - Evidence-Based Medicine
MH  - *Health Resources/statistics & numerical data
MH  - Humans
MH  - Life Expectancy
MH  - Molecular Targeted Therapy/methods/standards/trends
MH  - *Patient Selection
MH  - *Randomized Controlled Trials as Topic/methods/statistics & numerical data
MH  - *Reproducibility of Results
MH  - *Research Design/standards/trends
MH  - Sample Size
MH  - Selection Bias
MH  - Time Factors
MH  - Treatment Failure
PMC - PMC3139588
EDAT- 2011/06/29 06:00
MHDA- 2011/09/08 06:00
CRDT- 2011/06/29 06:00
PHST- 2011/06/29 06:00 [entrez]
PHST- 2011/06/29 06:00 [pubmed]
PHST- 2011/09/08 06:00 [medline]
AID - djr218 [pii]
AID - 10.1093/jnci/djr218 [doi]
PST - ppublish
SO  - J Natl Cancer Inst. 2011 Jul 20;103(14):1093-100. doi: 10.1093/jnci/djr218. Epub 
      2011 Jun 27.


PMID- 21708833
OWN - NLM
STAT- MEDLINE
DCOM- 20120322
LR  - 20111216
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 1
DP  - 2012 Jan
TI  - A clear case for conscience in healthcare practice.
PG  - 13-7
LID - 10.1136/jme.2011.043653 [doi]
AB  - The value of conscience in healthcare ethics is widely debated. While some
      sources present it as an unquestionably positive attribute, others question both 
      the veracity of its decisions and the effect of conscientious objection on
      patient access to health care. This paper argues that the right to object
      conscientiously should be broadened, subject to certain previsos, as there are
      many benefits to healthcare practice in the development of the consciences of
      practitioners. While effects such as the preservation of moral integrity are
      widely considered to benefit practitioners, this paper draws on the work of
      Hannah Arendt to offer several original arguments in defence of conscience that
      may more directly benefit patients, namely that a pang of conscience may be
      useful in rapidly unfolding situations in which there is no time to reflect
      satisfactorily upon activities and that, given the hierarchical nature of
      healthcare institutions, a right to defy authority on the basis of conscience may
      benefit junior staff who lack the institutional power to challenge the orders of 
      superiors.
FAU - Birchley, Giles
AU  - Birchley G
AD  - Paediatric Intensive Care Unit, Bristol Royal Hospital for Children, Upper
      Maudlin Street, Bristol, UK. gbirchley@blueyonder.co.uk
LA  - eng
PT  - Journal Article
DEP - 20110627
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Conscience
MH  - Decision Making/ethics
MH  - Ethics, Medical
MH  - Health Services Accessibility/*ethics
MH  - Human Rights
MH  - Humans
MH  - Moral Obligations
MH  - Quality of Health Care/*ethics
MH  - Refusal to Treat/ethics
EDAT- 2011/06/29 06:00
MHDA- 2012/03/23 06:00
CRDT- 2011/06/29 06:00
PHST- 2011/06/29 06:00 [entrez]
PHST- 2011/06/29 06:00 [pubmed]
PHST- 2012/03/23 06:00 [medline]
AID - jme.2011.043653 [pii]
AID - 10.1136/jme.2011.043653 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Jan;38(1):13-7. doi: 10.1136/jme.2011.043653. Epub 2011 Jun
      27.


PMID- 21708829
OWN - NLM
STAT- MEDLINE
DCOM- 20120322
LR  - 20111216
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 1
DP  - 2012 Jan
TI  - Privacy, confidentiality and abortion statistics: a question of public interest?
PG  - 31-4
LID - 10.1136/jme.2010.041186 [doi]
AB  - The precise nature and scope of healthcare confidentiality has long been the
      subject of debate. While the obligation of confidentiality is integral to
      professional ethical codes and is also safeguarded under English law through the 
      equitable remedy of breach of confidence, underpinned by the right to privacy
      enshrined in Article 8 of the Human Rights Act 1998, it has never been regarded
      as absolute. But when can and should personal information be made available for
      statistical and research purposes and what if the information in question is
      highly sensitive information, such as that relating to the termination of
      pregnancy after 24 weeks? This article explores the case of In the Matter of an
      Appeal to the Information Tribunal under section 57 of the Freedom of Information
      Act 2000, concerning the decision of the Department of Health to withhold some
      statistical data from the publication of its annual abortion statistics. The
      specific data being withheld concerned the termination for serious fetal handicap
      under section 1(1)d of the Abortion Act 1967. The paper explores the implications
      of this case, which relate both to the nature and scope of personal privacy. It
      suggests that lessons can be drawn from this case about public interest and use
      of statistical information and also about general policy issues concerning the
      legal regulation of confidentiality and privacy in the future.
FAU - McHale, Jean V
AU  - McHale JV
AD  - School of Law, University of Birmingham, Edgbaston, Birmingham, UK.
      j.v.mchale@bham.ac.uk
FAU - Jones, June
AU  - Jones J
LA  - eng
PT  - Journal Article
DEP - 20110627
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Abortion, Induced/*statistics & numerical data
MH  - Access to Information/*ethics/legislation & jurisprudence
MH  - Confidentiality/ethics/legislation & jurisprudence
MH  - Ethics, Medical
MH  - Female
MH  - Gestational Age
MH  - Humans
MH  - Jurisprudence
MH  - Pregnancy
MH  - Privacy/legislation & jurisprudence
MH  - Public Policy
EDAT- 2011/06/29 06:00
MHDA- 2012/03/23 06:00
CRDT- 2011/06/29 06:00
PHST- 2011/06/29 06:00 [entrez]
PHST- 2011/06/29 06:00 [pubmed]
PHST- 2012/03/23 06:00 [medline]
AID - jme.2010.041186 [pii]
AID - 10.1136/jme.2010.041186 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Jan;38(1):31-4. doi: 10.1136/jme.2010.041186. Epub 2011 Jun
      27.


PMID- 21708795
OWN - NLM
STAT- MEDLINE
DCOM- 20111013
LR  - 20110802
IS  - 1098-4275 (Electronic)
IS  - 0031-4005 (Linking)
VI  - 128
IP  - 2
DP  - 2011 Aug
TI  - Protecting children from sexual abuse by health care providers.
PG  - 407-26
LID - 10.1542/peds.2011-1244 [doi]
AB  - Sexual abuse or exploitation of children is never acceptable. Such behavior by
      health care providers is particularly concerning because of the trust that
      children and their families place on adults in the health care profession. The
      American Academy of Pediatrics strongly endorses the social and moral prohibition
      against sexual abuse or exploitation of children by health care providers. The
      academy opposes any such sexual abuse or exploitation by providers, particularly 
      by the academy's members. Health care providers should be trained to recognize
      and abide by appropriate provider-patient boundaries. Medical institutions should
      screen staff members for a history of child abuse issues, train them to respect
      and maintain appropriate boundaries, and establish policies and procedures to
      receive and investigate concerns about patient abuse. Each person has a
      responsibility to ensure the safety of children in health care settings and to
      scrupulously follow appropriate legal and ethical reporting and investigation
      procedures.
CN  - Committee on Child Abuse and Neglect
LA  - eng
PT  - Journal Article
DEP - 20110627
PL  - United States
TA  - Pediatrics
JT  - Pediatrics
JID - 0376422
SB  - IM
MH  - Academies and Institutes/ethics/*standards
MH  - Child
MH  - Child Abuse, Sexual/ethics/*prevention & control/psychology
MH  - Health Personnel/ethics/psychology/*standards
MH  - Humans
MH  - *Organizational Policy
MH  - Pediatrics/ethics/*standards
MH  - *Physician-Patient Relations/ethics
MH  - United States
IR  - Christian CW
FIR - Christian, Cindy W
IR  - Feldman KW
FIR - Feldman, Kenneth W
IR  - Christian CW
FIR - Christian, Cindy W
IR  - Crawford-Jakubiak JE
FIR - Crawford-Jakubiak, James E
IR  - Flaherty EG
FIR - Flaherty, Emalee G
IR  - Kaplan R
FIR - Kaplan, Rich
IR  - Lukefahr JL
FIR - Lukefahr, James L
IR  - Sege RD
FIR - Sege, Robert D
IR  - Feldman KW
FIR - Feldman, Kenneth W
IR  - MacMillan H
FIR - MacMillan, Harriet
IR  - Saul J
FIR - Saul, Janet
IR  - Hurley TP
FIR - Hurley, Tammy Piazza
EDAT- 2011/06/29 06:00
MHDA- 2011/10/14 06:00
CRDT- 2011/06/29 06:00
PHST- 2011/06/29 06:00 [entrez]
PHST- 2011/06/29 06:00 [pubmed]
PHST- 2011/10/14 06:00 [medline]
AID - peds.2011-1244 [pii]
AID - 10.1542/peds.2011-1244 [doi]
PST - ppublish
SO  - Pediatrics. 2011 Aug;128(2):407-26. doi: 10.1542/peds.2011-1244. Epub 2011 Jun
      27.


PMID- 21708421
OWN - NLM
STAT- MEDLINE
DCOM- 20120319
LR  - 20141120
IS  - 1095-8630 (Electronic)
IS  - 0301-4797 (Linking)
VI  - 92
IP  - 10
DP  - 2011 Oct
TI  - Remediation technologies for heavy metal contaminated groundwater.
PG  - 2355-88
LID - 10.1016/j.jenvman.2011.06.009 [doi]
AB  - The contamination of groundwater by heavy metal, originating either from natural 
      soil sources or from anthropogenic sources is a matter of utmost concern to the
      public health. Remediation of contaminated groundwater is of highest priority
      since billions of people all over the world use it for drinking purpose. In this 
      paper, thirty five approaches for groundwater treatment have been reviewed and
      classified under three large categories viz chemical,
      biochemical/biological/biosorption and physico-chemical treatment processes.
      Comparison tables have been provided at the end of each process for a better
      understanding of each category. Selection of a suitable technology for
      contamination remediation at a particular site is one of the most challenging job
      due to extremely complex soil chemistry and aquifer characteristics and no
      thumb-rule can be suggested regarding this issue. In the past decade, iron based 
      technologies, microbial remediation, biological sulphate reduction and various
      adsorbents played versatile and efficient remediation roles. Keeping the
      sustainability issues and environmental ethics in mind, the technologies
      encompassing natural chemistry, bioremediation and biosorption are recommended to
      be adopted in appropriate cases. In many places, two or more techniques can work 
      synergistically for better results. Processes such as chelate extraction and
      chemical soil washings are advisable only for recovery of valuable metals in
      highly contaminated industrial sites depending on economical feasibility.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Hashim, M A
AU  - Hashim MA
AD  - Department of Chemical Engineering, University of Malaya, Pantai Valley, 50603
      Kuala Lumpur, Malaysia. alihashim@um.edu.my
FAU - Mukhopadhyay, Soumyadeep
AU  - Mukhopadhyay S
FAU - Sahu, Jaya Narayan
AU  - Sahu JN
FAU - Sengupta, Bhaskar
AU  - Sengupta B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110625
PL  - England
TA  - J Environ Manage
JT  - Journal of environmental management
JID - 0401664
RN  - 0 (Drinking Water)
RN  - 0 (Metals, Heavy)
RN  - 0 (Soil Pollutants)
RN  - 0 (Water Pollutants)
SB  - IM
MH  - Conservation of Natural Resources/*methods
MH  - *Drinking Water
MH  - Environmental Restoration and Remediation/*methods
MH  - *Groundwater
MH  - Humans
MH  - *Metals, Heavy
MH  - Soil Pollutants
MH  - Water Pollutants
MH  - *Water Pollution
MH  - Water Purification/*methods
EDAT- 2011/06/29 06:00
MHDA- 2012/03/20 06:00
CRDT- 2011/06/29 06:00
PHST- 2011/01/06 00:00 [received]
PHST- 2011/05/17 00:00 [revised]
PHST- 2011/06/03 00:00 [accepted]
PHST- 2011/06/29 06:00 [entrez]
PHST- 2011/06/29 06:00 [pubmed]
PHST- 2012/03/20 06:00 [medline]
AID - S0301-4797(11)00206-4 [pii]
AID - 10.1016/j.jenvman.2011.06.009 [doi]
PST - ppublish
SO  - J Environ Manage. 2011 Oct;92(10):2355-88. doi: 10.1016/j.jenvman.2011.06.009.
      Epub 2011 Jun 25.


PMID- 21708368
OWN - NLM
STAT- MEDLINE
DCOM- 20111121
LR  - 20220408
IS  - 1878-7452 (Electronic)
IS  - 1878-7452 (Linking)
VI  - 68
IP  - 4
DP  - 2011 Jul-Aug
TI  - The use of a multidisciplinary morbidity and mortality conference to incorporate 
      ACGME general competencies.
PG  - 303-8
LID - 10.1016/j.jsurg.2011.02.002 [doi]
AB  - BACKGROUND: The Surgical Morbidity and Mortality conference has long been used as
      an opportunity for both process improvement and resident education. With recent
      heightened focus on creating environments of safety and on meeting the
      Accreditation Council for Graduate Medical Education (ACGME) General
      Competencies, novel approaches are required. With the understanding that the
      provision of medical care is an inherently multidisciplinary enterprise, we
      advocate the creation and use of a Multidisciplinary Morbidity and Mortality
      conference (MM&M) as a means to establish this culture of safety while teaching
      the ACGME General Competencies to surgery residents. METHODS: A quarterly MM&M
      conference was implemented to foster communication between disciplines, provide a
      forum for quality improvement, and enhance patient care. All stakeholders in the 
      perioperative enterprise attend, including the departments of surgery,
      anesthesia, radiology, pharmacy, nursing, environmental services, risk
      management, and patient services. Cases that expose system issues with potential 
      to harm patients are discussed in an open, nonconfrontational forum. Solutions
      are presented and initiatives developed to improve patient outcomes. We
      retrospectively reviewed the topics presented since the conference's inception,
      grouping them into 1 of 7 categories. We then evaluated the completion of the
      improvement initiatives developed after discussion at the conference. RESULTS:
      Over a 21-month period, 11 cases were discussed with 23 "actionable" initiatives 
      for quality improvement. Cases were grouped by category; procedures (36.5%),
      process (36.5%), patient-related (9%), communication (9%), medication (9%),
      device (0%), and ethics (0%). All cases discussed addressed at least 4 of the 6
      ACGME General Competencies. CONCLUSIONS: Like the practice of medicine, the
      occurrence of adverse outcomes is frequently multidisciplinary. An MM&M
      conference is useful in its potential to meet ACGME General Competencies,
      engender a culture of patient safety, and rapidly achieve quality improvement and
      systems health care delivery initiatives in a large academic medical center.
CI  - Copyright (c) 2011 Association of Program Directors in Surgery. Published by
      Elsevier Inc. All rights reserved.
FAU - Kauffmann, Rondi M
AU  - Kauffmann RM
AD  - Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee
      37232-2730, USA. rondi.kauffmann@vanderbilt.edu
FAU - Landman, Matthew P
AU  - Landman MP
FAU - Shelton, Julia
AU  - Shelton J
FAU - Dmochowski, Roger R
AU  - Dmochowski RR
FAU - Bledsoe, Sandra H
AU  - Bledsoe SH
FAU - Hickson, Gerald B
AU  - Hickson GB
FAU - Beauchamp, R Daniel
AU  - Beauchamp RD
FAU - Dattilo, Jeffery B
AU  - Dattilo JB
LA  - eng
GR  - T32 DK007061/DK/NIDDK NIH HHS/United States
GR  - T32 HS013833/HS/AHRQ HHS/United States
GR  - T32 DK007061-35/DK/NIDDK NIH HHS/United States
GR  - T32 HS013833-08/HS/AHRQ HHS/United States
GR  - 5T32DK007061-35/DK/NIDDK NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20110325
PL  - United States
TA  - J Surg Educ
JT  - Journal of surgical education
JID - 101303204
SB  - IM
MH  - Accreditation/*standards
MH  - *Clinical Competence
MH  - *Congresses as Topic
MH  - Education, Medical, Graduate/standards/trends
MH  - General Surgery/*education
MH  - Humans
MH  - Interdisciplinary Communication
MH  - Internship and Residency
MH  - Male
MH  - Morbidity
MH  - Mortality
MH  - Quality Improvement
MH  - Retrospective Studies
MH  - United States
PMC - PMC3128423
MID - NIHMS275205
EDAT- 2011/06/29 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/06/29 06:00
PHST- 2011/01/10 00:00 [received]
PHST- 2011/02/04 00:00 [accepted]
PHST- 2011/06/29 06:00 [entrez]
PHST- 2011/06/29 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S1931-7204(11)00051-1 [pii]
AID - 10.1016/j.jsurg.2011.02.002 [doi]
PST - ppublish
SO  - J Surg Educ. 2011 Jul-Aug;68(4):303-8. doi: 10.1016/j.jsurg.2011.02.002. Epub
      2011 Mar 25.


PMID- 21707952
OWN - NLM
STAT- MEDLINE
DCOM- 20111019
LR  - 20211020
IS  - 1752-8062 (Electronic)
IS  - 1752-8054 (Linking)
VI  - 4
IP  - 3
DP  - 2011 Jun
TI  - Pharmacotherapy and pregnancy: highlights from the Third International Conference
      for Individualized Pharmacotherapy in Pregnancy.
PG  - 204-9
LID - 10.1111/j.1752-8062.2011.00280.x [doi]
AB  - To address provider struggles to provide evidence-based, rational drug therapy to
      pregnant women, this third Conference was convened to highlight the current
      progress and research in the field. Speakers from academic centers, industry, and
      governmental institutions spoke about: the Food and Drug Administration's role in
      pregnancy pharmacology and the new labeling initiative; drug registries in
      pregnancy; the pharmacist's role in medication use in pregnancy; therapeutic
      areas such as preterm labor, gestational diabetes, nausea and vomiting in
      pregnancy, and hypertension; breast-feeding and medications; ethical challenges
      for consent in pregnancy drug studies; the potential for cord blood banks; and
      concerns about the fetus when studying drugs in pregnancy. The Conference
      highlighted several areas of collaboration within the current Obstetrics
      Pharmacology Research Units Network and hoped to educate providers, researchers, 
      and agencies with the common goal to improve the ability to safely and
      effectively use individualized pharmacotherapy in pregnancy.
CI  - (c) 2011 Wiley Periodicals, Inc.
FAU - Haas, David M
AU  - Haas DM
AD  - Indiana University School of Medicine, Indianapolis, IN, USA. dahaas@iupui.edu
FAU - Gallauresi, Beverly
AU  - Gallauresi B
FAU - Shields, Kristine
AU  - Shields K
FAU - Zeitlin, Deborah
AU  - Zeitlin D
FAU - Clark, Shannon M
AU  - Clark SM
FAU - Hebert, Mary F
AU  - Hebert MF
FAU - Ren, Zhaoxia
AU  - Ren Z
FAU - Nallani, Srikanth C
AU  - Nallani SC
FAU - Meslin, Eric M
AU  - Meslin EM
FAU - Feibus, Karen B
AU  - Feibus KB
FAU - Koren, Gideon
AU  - Koren G
FAU - Goebel, W Scott
AU  - Goebel WS
FAU - Easterling, Thomas
AU  - Easterling T
FAU - Denne, Scott C
AU  - Denne SC
FAU - Flockhart, David A
AU  - Flockhart DA
FAU - Renbarger, Jamie L
AU  - Renbarger JL
LA  - eng
GR  - U10 HD063094/HD/NICHD NIH HHS/United States
GR  - U10 HD063094-01/HD/NICHD NIH HHS/United States
PT  - Congress
PL  - United States
TA  - Clin Transl Sci
JT  - Clinical and translational science
JID - 101474067
SB  - IM
MH  - Abnormalities, Drug-Induced/*prevention & control
MH  - Breast Feeding
MH  - *Drug-Related Side Effects and Adverse Reactions
MH  - Female
MH  - Humans
MH  - Hypertension/complications/drug therapy
MH  - Infant, Newborn
MH  - National Institutes of Health (U.S.)
MH  - Nausea/complications/drug therapy
MH  - Obstetrics/methods
MH  - Pregnancy
MH  - Pregnancy Complications/*drug therapy
MH  - Registries
MH  - United States
MH  - United States Food and Drug Administration
PMC - PMC3128426
MID - NIHMS287688
EDAT- 2011/06/29 06:00
MHDA- 2011/10/20 06:00
CRDT- 2011/06/29 06:00
PHST- 2011/06/29 06:00 [entrez]
PHST- 2011/06/29 06:00 [pubmed]
PHST- 2011/10/20 06:00 [medline]
AID - 10.1111/j.1752-8062.2011.00280.x [doi]
PST - ppublish
SO  - Clin Transl Sci. 2011 Jun;4(3):204-9. doi: 10.1111/j.1752-8062.2011.00280.x.


PMID- 21707893
OWN - NLM
STAT- MEDLINE
DCOM- 20120514
LR  - 20110628
IS  - 1445-5994 (Electronic)
IS  - 1444-0903 (Linking)
VI  - 41
IP  - 6
DP  - 2011 Jun
TI  - Palliative care, double effect and the law in Australia.
PG  - 485-92
LID - 10.1111/j.1445-5994.2011.02511.x [doi]
AB  - Care and decision-making at the end of life that promotes comfort and dignity is 
      widely endorsed by public policy and the law. In ethical analysis of palliative
      care interventions that are argued potentially to hasten death, these may be
      deemed to be ethically permissible by the application of the doctrine of double
      effect, if the doctor's intention is to relieve pain and not cause death. In part
      because of the significance of ethics in the development of law in the medical
      sphere, this doctrine is also likely to be recognized as part of Australia's
      common law, although hitherto there have been no cases concerning palliative care
      brought before a court in Australia to test this. Three Australian States have,
      nonetheless, created legislative defences that are different from the common law 
      with the intent of clarifying the law, promoting palliative care, and
      distinguishing it from euthanasia. However, these defences have the potential to 
      provide less protection for doctors administering palliative care. In addition to
      requiring a doctor to have an appropriate intent, the defences insist on
      adherence to particular medical practice standards and perhaps require patient
      consent. Doctors providing end-of-life care in these States need to be aware of
      these legislative changes. Acting in accordance with the common law doctrine of
      double effect may not provide legal protection. Similar changes are likely to
      occur in other States and Territories as there is a trend towards enacting
      legislative defences that deal with the provision of palliative care.
CI  - (c) 2011 The Authors. Internal Medicine Journal (c) 2011 Royal Australasian
      College of Physicians.
FAU - White, B P
AU  - White BP
AD  - Health Law Research Program, Faculty of Law, Queensland University of Technology,
      Brisbane, Queensland, Australia. bp.white@qut.edu.au
FAU - Willmott, L
AU  - Willmott L
FAU - Ashby, M
AU  - Ashby M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Australia
TA  - Intern Med J
JT  - Internal medicine journal
JID - 101092952
SB  - IM
CIN - Intern Med J. 2011 Jun;41(6):439-40. PMID: 21707892
MH  - Australia
MH  - Decision Making
MH  - *Double Effect Principle
MH  - Ethics, Medical
MH  - Humans
MH  - Palliative Care/*ethics/*legislation & jurisprudence
MH  - Terminal Care/*ethics/*legislation & jurisprudence
EDAT- 2011/06/29 06:00
MHDA- 2012/05/15 06:00
CRDT- 2011/06/29 06:00
PHST- 2011/06/29 06:00 [entrez]
PHST- 2011/06/29 06:00 [pubmed]
PHST- 2012/05/15 06:00 [medline]
AID - 10.1111/j.1445-5994.2011.02511.x [doi]
PST - ppublish
SO  - Intern Med J. 2011 Jun;41(6):485-92. doi: 10.1111/j.1445-5994.2011.02511.x.


PMID- 21707460
OWN - NLM
STAT- MEDLINE
DCOM- 20120210
LR  - 20110628
IS  - 1744-8352 (Electronic)
IS  - 1473-7159 (Linking)
VI  - 11
IP  - 5
DP  - 2011 Jun
TI  - Oligonucleotide microarrays in constitutional genetic diagnosis.
PG  - 521-32
LID - 10.1586/ERM.11.32 [doi]
AB  - Oligonucleotide microarrays such as comparative genomic hybridization arrays and 
      SNP microarrays enable the identification of genomic imbalances - also termed
      copy-number variants - with increasing resolution. This article will focus on the
      most significant applications of high-throughput oligonucleotide microarrays,
      both in genetic diagnosis and research. In genetic diagnosis, the method is
      becoming a standard tool for investigating patients with unexplained
      developmental delay/intellectual disability, autism spectrum disorders and/or
      with multiple congenital anomalies. Oligonucleotide microarray have also been
      recently applied to the detection of genomic imbalances in prenatal diagnosis
      either to characterize a chromosomal rearrangement that has previously been
      identified by standard prenatal karyotyping or to detect a cryptic genomic
      imbalance in a fetus with ultrasound abnormalities and a normal standard prenatal
      karyotype. In research, oligonucleotide microarrays have been used for a wide
      range of applications, such as the identification of new genes responsible for
      monogenic disorders and the association of a copy-number variant as a
      predisposing factor to a common disease. Despite its widespread use, the
      interpretation of results is not always straightforward. We will discuss several 
      unexpected results and ethical issues raised by these new methods.
FAU - Keren, Boris
AU  - Keren B
AD  - Groupe Hospitalier Pitie-Salpetriere, Assistance Publique-Hopitaux de Paris,
      Departement de Genetique et Cytogenetique, France.
FAU - Le Caignec, Cedric
AU  - Le Caignec C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Expert Rev Mol Diagn
JT  - Expert review of molecular diagnostics
JID - 101120777
SB  - IM
MH  - *Abnormalities, Multiple/diagnosis/genetics
MH  - *Autistic Disorder/diagnosis/genetics
MH  - Child
MH  - Comparative Genomic Hybridization/methods
MH  - DNA Copy Number Variations/genetics
MH  - *Developmental Disabilities/diagnosis/genetics
MH  - Female
MH  - Fetus/abnormalities
MH  - Gene Rearrangement/genetics
MH  - Humans
MH  - *Intellectual Disability/diagnosis/genetics
MH  - Karyotyping/methods
MH  - Male
MH  - Molecular Diagnostic Techniques/methods
MH  - *Oligonucleotide Array Sequence Analysis/economics/methods
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Pregnancy
MH  - Prenatal Diagnosis/*methods
EDAT- 2011/06/29 06:00
MHDA- 2012/02/11 06:00
CRDT- 2011/06/29 06:00
PHST- 2011/06/29 06:00 [entrez]
PHST- 2011/06/29 06:00 [pubmed]
PHST- 2012/02/11 06:00 [medline]
AID - 10.1586/erm.11.32 [doi]
PST - ppublish
SO  - Expert Rev Mol Diagn. 2011 Jun;11(5):521-32. doi: 10.1586/erm.11.32.


PMID- 21707418
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20110628
IS  - 1545-5815 (Electronic)
IS  - 0898-9621 (Linking)
VI  - 18
IP  - 4
DP  - 2011 Jul-Aug
TI  - Informed consent of very sick subjects in Nigeria.
PG  - 289-96
LID - 10.1080/08989621.2011.584766 [doi]
AB  - This article highlights a number of ethical challenges I face in obtaining
      informed consent from very sick subjects with suspected pulmonary tuberculosis
      (TB). Some of the subjects with TB have an associated human immunodeficiency
      virus (HIV) infection. From my experience in administering informed consent and
      health surveys, I found the subjects to be generally mentally stable but
      physically exhausted. Many of the very sick subjects cough excessively and cannot
      tolerate a 45-minute conversation with the study staff in order for them to
      administer consent and conduct a survey after the routine clinical evaluation. In
      this situation, the administration of a qualitative consent that preserves the
      subject's right and autonomy becomes a challenge.
FAU - Aliyu, Gambo G
AU  - Aliyu GG
AD  - Institute of Human Virology University of Maryland School of Medicine, Baltimore,
      Maryland, USA. algambo@yahoo.com
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Account Res
JT  - Accountability in research
JID - 9100813
SB  - IM
MH  - Decision Making
MH  - HIV Infections/*psychology
MH  - Humans
MH  - Immunocompromised Host
MH  - Informed Consent/*ethics
MH  - Nigeria
MH  - Risk Factors
MH  - Tuberculosis, Pulmonary/*psychology
EDAT- 2011/06/29 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/06/29 06:00
PHST- 2011/06/29 06:00 [entrez]
PHST- 2011/06/29 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - 10.1080/08989621.2011.584766 [doi]
PST - ppublish
SO  - Account Res. 2011 Jul-Aug;18(4):289-96. doi: 10.1080/08989621.2011.584766.


PMID- 21707348
OWN - NLM
STAT- MEDLINE
DCOM- 20111222
LR  - 20110628
IS  - 1937-190X (Electronic)
IS  - 1937-190X (Linking)
VI  - 26
IP  - 4
DP  - 2011
TI  - An education model for integrating genetics and genomics into social work
      practice.
PG  - 392-404
LID - 10.1080/10911350902990924 [doi]
AB  - Findings from the Human Genome Project (HGP) suggest that tremendous
      opportunities exist for increased life expectancies and improved quality of life.
      The findings also raise enormous concerns about ethical, legal, and psychosocial 
      implications, particularly for underrepresented and vulnerable populations. This 
      article proposes an education model that focuses on genetically informed, ethical
      practice that will help social worker practitioners and educators play a more
      effective role as they confront the many implications of genetic and genomic
      research in the 21st century.
FAU - Kingsberry, Sheridan Quarless
AU  - Kingsberry SQ
AD  - Department of Social Work, Delaware State University, Wilmington, Delaware 19801,
      USA. sqkingsberry@desu.edu
FAU - Mickel, Elijah
AU  - Mickel E
FAU - Wartel, Stephen G
AU  - Wartel SG
FAU - Holmes, Vermeadia
AU  - Holmes V
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Soc Work Public Health
JT  - Social work in public health
JID - 101308228
MH  - African Americans
MH  - *Biomedical Research
MH  - Consumer Advocacy
MH  - Curriculum
MH  - Evidence-Based Practice/*methods
MH  - Human Genome Project
MH  - Humans
MH  - *Models, Educational
MH  - Patient Care Team
MH  - Professional Competence
MH  - Social Work/education/*methods
MH  - United States
EDAT- 2011/06/29 06:00
MHDA- 2011/12/23 06:00
CRDT- 2011/06/29 06:00
PHST- 2011/06/29 06:00 [entrez]
PHST- 2011/06/29 06:00 [pubmed]
PHST- 2011/12/23 06:00 [medline]
AID - 10.1080/10911350902990924 [doi]
PST - ppublish
SO  - Soc Work Public Health. 2011;26(4):392-404. doi: 10.1080/10911350902990924.


PMID- 21707284
OWN - NLM
STAT- MEDLINE
DCOM- 20111021
LR  - 20220321
IS  - 1744-8328 (Electronic)
IS  - 1473-7140 (Linking)
VI  - 11
IP  - 6
DP  - 2011 Jun
TI  - Quality of reporting in randomized controlled trials conducted in China on the
      treatment of cancer pain.
PG  - 871-7
LID - 10.1586/era.10.236 [doi]
AB  - BACKGROUND: Research in China has been rapidly gaining momentum, but as yet there
      is no systematic evaluation of quality of reporting in randomized controlled
      trials (RCTs) on the treatment of cancer pain conducted in China. Therefore, an
      assessment in this field is an imperative issue. METHODS: A PubMed search of
      reports published between 1994 and 2009 followed by an examination and critical
      appraisal of reporting in RCTs on the treatment of cancer pain was conducted in
      China. All reports had been examined to describe their general characteristics
      and evaluate the quality of their reporting. Quality of reporting was assessed
      against a subset of criteria adapted from the Consolidated Standards of Reporting
      Trials (CONSORT) statement. RESULTS: A total of 46 RCTs were included in full
      text. The frequency of RCTs was found to increase over time: from one (2.2%) in
      1994-1997 to 28 (60.9%) in 2006-2009. There were fewer papers published in this
      field in foreign journals, as funding sources and opportunities for collaborative
      research with foreigners are still limited. Visual analogue scales were the main 
      method of cancer pain evaluation (19 reports; 41.4%). Only 12 studies (26.1%) are
      deemed to have authentic randomization and 36 papers (78.3%) provided no
      information about blinding of either participants or investigators. In 22 papers 
      (47.8%), there was no information about the length of time for which participants
      were followed. Only 15 (32.6%) of the included trials reported approval by an
      ethics committee and 17 (37.0%) adequately discussed informed consent.
      CONCLUSION: The quality of reporting in RCTs on the treatment of cancer pain
      conducted in China needs to be improved. Three critical steps should be strictly 
      conducted including randomization, blinding and follow-up. Reporting of RCTs in
      this field conducted in China should meet and keep up with the standards of
      CONSORT statement.
FAU - Lu, Liming
AU  - Lu L
AD  - Department of Oncology, First Affiliated Hospital, Guangzhou University of
      Chinese Medicine, Guangzhou 510405, China. lulimingleon@126.com
FAU - Zeng, Jingchun
AU  - Zeng J
FAU - Chen, Ying
AU  - Chen Y
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Expert Rev Anticancer Ther
JT  - Expert review of anticancer therapy
JID - 101123358
SB  - IM
MH  - China
MH  - Cooperative Behavior
MH  - Humans
MH  - Neoplasms/physiopathology/*therapy
MH  - Pain/etiology
MH  - *Pain Management
MH  - Pain Measurement
MH  - Randomized Controlled Trials as Topic/methods/*standards
EDAT- 2011/06/29 06:00
MHDA- 2011/10/22 06:00
CRDT- 2011/06/29 06:00
PHST- 2011/06/29 06:00 [entrez]
PHST- 2011/06/29 06:00 [pubmed]
PHST- 2011/10/22 06:00 [medline]
AID - 10.1586/era.10.236 [doi]
PST - ppublish
SO  - Expert Rev Anticancer Ther. 2011 Jun;11(6):871-7. doi: 10.1586/era.10.236.


PMID- 21707013
OWN - NLM
STAT- MEDLINE
DCOM- 20110728
LR  - 20211203
IS  - 0026-556X (Print)
IS  - 0026-556X (Linking)
VI  - 94
IP  - 5
DP  - 2011 May
TI  - Hand transplantation.
PG  - 40-3
AB  - The first successful hand transplant was performed in 1998, opening up a new
      possibility for patients who have suffered mutilating hand injuries. Since then, 
      more than 60 such procedures have been performed throughout the world. This
      article describes the evolution of hand transplantation, outcomes of patients
      listed in the International Registry of Hand and Composite Tissue
      Transplantation, and ethical issues involved in hand transplantation. It also
      describes the hand transplantation program at Mayo Clinic, which was established 
      in 2010.
FAU - Amer, Hatem
AU  - Amer H
AD  - Mayo Clinic, Rochester, USA.
FAU - Carlsen, Brian T
AU  - Carlsen BT
FAU - Dusso, Jennifer L
AU  - Dusso JL
FAU - Edwards, Brooks S
AU  - Edwards BS
FAU - Moran, Steven L
AU  - Moran SL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Minn Med
JT  - Minnesota medicine
JID - 8000173
SB  - IM
MH  - Academic Medical Centers/ethics
MH  - Amputation, Traumatic/*surgery
MH  - Ethics, Medical
MH  - Graft Rejection/etiology/psychology
MH  - Hand Injuries/*surgery
MH  - *Hand Transplantation
MH  - Humans
MH  - Immunosuppression Therapy/ethics/methods
MH  - Microsurgery/ethics/*methods
MH  - Minnesota
MH  - Postoperative Complications/etiology/psychology
MH  - Quality of Life/psychology
MH  - *Registries
EDAT- 2011/06/29 06:00
MHDA- 2011/07/29 06:00
CRDT- 2011/06/29 06:00
PHST- 2011/06/29 06:00 [entrez]
PHST- 2011/06/29 06:00 [pubmed]
PHST- 2011/07/29 06:00 [medline]
PST - ppublish
SO  - Minn Med. 2011 May;94(5):40-3.


PMID- 21706993
OWN - NLM
STAT- MEDLINE
DCOM- 20110719
LR  - 20191210
IS  - 1322-7696 (Print)
IS  - 1322-7696 (Linking)
VI  - 18
IP  - 2
DP  - 2011
TI  - An exploration of the role and scope of the clinical nurse consultant (CNC) in a 
      metropolitan health service.
PG  - 61-9
AB  - INTRODUCTION: Clinical nurse consultants have been a part of the nursing
      workforce for some time however a lack of clarity regarding this role has led to 
      significant variations in health service expectations, workloads and scope for
      the Clinical nurse consultants working within this metropolitan health service.
      AIM: The aim of this study was to explore the role of the CNC as it is perceived 
      by them, in the context of this health service. METHOD: A qualitative approach
      was used for this study. Following ethics approval a single audio-taped focus
      group was undertaken to gather data. Guiding questions were used to elicit
      responses from the group, moderated by the co-investigators. The focus group was 
      transcribed verbatim. Each researcher independently analysed the narrative data, 
      using coding and clustering the data to develop primary and sub-themes. RESULTS: 
      Whilst each participant experiences their role individually, there were four
      themes derived from comments expressed by the participants: 'Diversity and
      conflict', 'Leaders but powerless', 'Support systems' and 'The portfolio holder
      role'. CONCLUSION: The role of the Clinical nurse consultant is complex and
      diverse. The variability in the role suggests that organisational consensus of
      the role, scope and purpose of the CNC position has not been actualised,
      resulting in a lack of support systems, and an underutilisation of the Clinical
      nurse consultants as leaders, where they can challenge existing practice and
      guide future directions in care delivery.
FAU - Bloomer, Melissa J
AU  - Bloomer MJ
AD  - Monash University, School of Nursing and Midwifery, Peninsula Campus, PO Box 527,
      Frankston, VIC 3199, Australia. melissa.bloomer@med.monash.edu.au
FAU - Cross, Wendy M
AU  - Cross WM
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Collegian
JT  - Collegian (Royal College of Nursing, Australia)
JID - 9612493
MH  - Adult
MH  - *Consultants
MH  - Female
MH  - Focus Groups
MH  - Humans
MH  - Leadership
MH  - Middle Aged
MH  - *Nurse Clinicians
MH  - *Nurse's Role
MH  - Power, Psychological
MH  - Social Support
MH  - *Task Performance and Analysis
MH  - *Urban Health Services
MH  - Victoria
MH  - Workforce
MH  - Workload
EDAT- 2011/06/29 06:00
MHDA- 2011/07/20 06:00
CRDT- 2011/06/29 06:00
PHST- 2011/06/29 06:00 [entrez]
PHST- 2011/06/29 06:00 [pubmed]
PHST- 2011/07/20 06:00 [medline]
AID - 10.1016/j.colegn.2010.09.002 [doi]
PST - ppublish
SO  - Collegian. 2011;18(2):61-9. doi: 10.1016/j.colegn.2010.09.002.


PMID- 21706357
OWN - NLM
STAT- MEDLINE
DCOM- 20131126
LR  - 20130304
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 1
DP  - 2013 Mar
TI  - Ethics as a beneficial Trojan horse in a technological society.
PG  - 13-26
LID - 10.1007/s11948-011-9287-x [doi]
AB  - This article explores the transformation of ethics in a globalizing technological
      society. After describing some basic features of this society, particularly the
      primacy it gives to a special type of technical rationality, three specific
      influences on traditional ethics are examined: (1) a change concerning the notion
      of value, (2) the decreasing relevance of the concept of axiological hierarchy,
      and (3) the new internal architecture of ethics as a net of values. These three
      characteristics suggest a new pragmatic understanding of ethics. From a pragmatic
      perspective, the process of introducing ethical values into contemporary society 
      can be regarded as a beneficial Trojan horse, a metaphor that will be developed
      further.
FAU - Queralto, Ramon
AU  - Queralto R
AD  - Faculty of Philosophy, University of Sevilla, Sevilla, Spain. queralto@us.es
LA  - eng
PT  - Journal Article
DEP - 20110626
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Ethical Analysis
MH  - *Ethical Theory
MH  - Humans
MH  - Internationality
MH  - Metaphor
MH  - *Social Values
MH  - Technology/*ethics
EDAT- 2011/06/28 06:00
MHDA- 2013/12/16 06:00
CRDT- 2011/06/28 06:00
PHST- 2011/02/24 00:00 [received]
PHST- 2011/06/16 00:00 [accepted]
PHST- 2011/06/28 06:00 [entrez]
PHST- 2011/06/28 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1007/s11948-011-9287-x [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Mar;19(1):13-26. doi: 10.1007/s11948-011-9287-x. Epub 2011
      Jun 26.


PMID- 21706343
OWN - NLM
STAT- MEDLINE
DCOM- 20110929
LR  - 20211020
IS  - 1432-1203 (Electronic)
IS  - 0340-6717 (Linking)
VI  - 130
IP  - 3
DP  - 2011 Sep
TI  - Closure of population biobanks and direct-to-consumer genetic testing companies.
PG  - 425-32
LID - 10.1007/s00439-011-1019-4 [doi]
AB  - Genetic research gained new momentum with the completion of the Human Genome
      Project in 2003. Formerly centered on the investigation of single-gene disorders,
      genetic research is increasingly targeting common complex diseases and in doing
      so is studying the whole genome, the environment and its impact on genomic
      variation. Consequently, biobanking initiatives have emerged around the world as 
      a tool to sustain such progress. Whether they are small scale or longitudinal,
      public or private, commercial or non-commercial, biobanks should consider the
      possibility of closure. Interestingly, while raising important ethical issues,
      this topic has hardly been explored in the literature. Indeed, ethical issues
      associated with sale, insolvency, end of funding, or transfer of materials to
      other entities (which are all issues either related to or possible consequences
      of closure) are seldom the subject of discussion. In an attempt to fill this gap,
      this paper will discuss-using population and direct-to-consumer (DTC) genetic
      testing companies' biobanks as case studies-(1) international and national
      normative documents addressing the issue of closure and (2) the internal policies
      of population biobanks and DTC genetic testing companies. The analysis will
      inform the debate on biobank closure and elucidate the underlying ethical issues,
      which include, but are not limited to informed consent, storage and privacy.
FAU - Zawati, Ma'n H
AU  - Zawati MH
AD  - Centre of Genomics and Policy, McGill University, 740 Dr. Penfield Avenue, Room
      5209, Montreal, QC H3A 1A4, Canada. man.zawati@mcgill.ca
FAU - Borry, Pascal
AU  - Borry P
FAU - Howard, Heidi Carmen
AU  - Howard HC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110626
PL  - Germany
TA  - Hum Genet
JT  - Human genetics
JID - 7613873
SB  - IM
MH  - *Biological Specimen Banks
MH  - Genetic Testing/ethics/*organization & administration
MH  - Genetics, Population
MH  - Guidelines as Topic
MH  - *Health Facility Closure
MH  - Humans
MH  - Informed Consent
MH  - Privacy
MH  - Specimen Handling
EDAT- 2011/06/28 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/06/28 06:00
PHST- 2011/05/12 00:00 [received]
PHST- 2011/05/24 00:00 [accepted]
PHST- 2011/06/28 06:00 [entrez]
PHST- 2011/06/28 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - 10.1007/s00439-011-1019-4 [doi]
PST - ppublish
SO  - Hum Genet. 2011 Sep;130(3):425-32. doi: 10.1007/s00439-011-1019-4. Epub 2011 Jun 
      26.


PMID- 21706342
OWN - NLM
STAT- MEDLINE
DCOM- 20110823
LR  - 20211020
IS  - 1432-1203 (Electronic)
IS  - 0340-6717 (Linking)
VI  - 130
IP  - 1
DP  - 2011 Jul
TI  - Personalized medicine: new genomics, old lessons.
PG  - 3-14
LID - 10.1007/s00439-011-1028-3 [doi]
AB  - Personalized medicine uses traditional, as well as emerging concepts of the
      genetic and environmental basis of disease to individualize prevention, diagnosis
      and treatment. Personalized genomics plays a vital, but not exclusive role in
      this evolving model of personalized medicine. The distinctions between genetic
      and genomic medicine are more quantitative than qualitative. Personalized
      genomics builds on principles established by the integration of genetics into
      medical practice. Principles shared by genetic and genomic aspects of medicine,
      include the use of variants as markers for diagnosis, prognosis, prevention, as
      well as targets for treatment, the use of clinically validated variants that may 
      not be functionally characterized, the segregation of these variants in
      non-Mendelian as well as Mendelian patterns, the role of gene--environment
      interactions, the dependence on evidence for clinical utility, the critical
      translational role of behavioral science, and common ethical considerations.
      During the current period of transition from investigation to practice, consumers
      should be protected from harms of premature translation of research findings,
      while encouraging the innovative and cost-effective application of those genomic 
      discoveries that improve personalized medical care.
FAU - Offit, Kenneth
AU  - Offit K
AD  - Clinical Genetics Service, Department of Medicine, Program in Cancer Biology and 
      Genetics, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New 
      York, NY 10021, USA. offitk@mskcc.org
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110626
PL  - Germany
TA  - Hum Genet
JT  - Human genetics
JID - 7613873
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Biotechnology
MH  - Gene Targeting
MH  - Genetic Markers
MH  - Genetic Variation
MH  - *Genomics/ethics
MH  - Humans
MH  - *Precision Medicine/ethics
MH  - Risk Assessment
PMC - PMC3128266
EDAT- 2011/06/28 06:00
MHDA- 2011/08/24 06:00
CRDT- 2011/06/28 06:00
PHST- 2011/02/10 00:00 [received]
PHST- 2011/05/30 00:00 [accepted]
PHST- 2011/06/28 06:00 [entrez]
PHST- 2011/06/28 06:00 [pubmed]
PHST- 2011/08/24 06:00 [medline]
AID - 10.1007/s00439-011-1028-3 [doi]
PST - ppublish
SO  - Hum Genet. 2011 Jul;130(1):3-14. doi: 10.1007/s00439-011-1028-3. Epub 2011 Jun
      26.


PMID- 21706268
OWN - NLM
STAT- MEDLINE
DCOM- 20120207
LR  - 20220409
IS  - 1525-1497 (Electronic)
IS  - 0884-8734 (Linking)
VI  - 26
IP  - 10
DP  - 2011 Oct
TI  - The patient-doctor relationship and online social networks: results of a national
      survey.
PG  - 1168-74
LID - 10.1007/s11606-011-1761-2 [doi]
AB  - BACKGROUND: The use of online social networks (OSNs) among physicians and
      physicians-in-training, the extent of patient-doctor interactions within OSNs,
      and attitudes among these groups toward use of OSNs is not well described.
      OBJECTIVE: To quantify the use of OSNs, patient interactions within OSNs, and
      attitudes toward OSNs among medical students (MS), resident physicians (RP), and 
      practicing physicians (PP) in the United States. DESIGN/SETTING: A random,
      stratified mail survey was sent to 1004 MS, 1004 RP, and 1004 PP between February
      and May 2010. MEASUREMENTS: Percentage of respondents reporting OSN use, the
      nature and frequency of use; percentage of respondents reporting friend requests 
      by patients or patients' family members, frequency of these requests, and whether
      or not they were accepted; attitudes toward physician use of OSNs and online
      patient interactions. RESULTS: The overall response rate was 16.0% (19.8% MS,
      14.3% RP, 14.1% PP). 93.5% of MS, 79.4% of RP, and 41.6% of PP reported usage of 
      OSNs. PP were more likely to report having visited the profile of a patient or
      patient's family member (MS 2.3%, RP 3.9%, PP 15.5%), and were more likely to
      have received friend requests from patients or their family members (MS 1.2%, RP 
      7.8%, PP 34.5%). A majority did not think it ethically acceptable to interact
      with patients within OSNs for either social (68.3%) or patient-care (68.0%)
      reasons. Almost half of respondents (48.7%) were pessimistic about the potential 
      for OSNs to improve patient-doctor communication, and a majority (79%) expressed 
      concerns about maintaining patient confidentiality. CONCLUSION: Personal OSN use 
      among physicians and physicians-in-training mirrors that of the general
      population. Patient-doctor interactions take place within OSNs, and are more
      typically initiated by patients than by physicians or physicians-in-training. A
      majority of respondents view these online interactions as ethically problematic.
FAU - Bosslet, Gabriel T
AU  - Bosslet GT
AD  - Indiana University Health, Indianapolis, IN 46202, USA. gbosslet@iupui.edu
FAU - Torke, Alexia M
AU  - Torke AM
FAU - Hickman, Susan E
AU  - Hickman SE
FAU - Terry, Colin L
AU  - Terry CL
FAU - Helft, Paul R
AU  - Helft PR
LA  - eng
GR  - K23 AG031323/AG/NIA NIH HHS/United States
GR  - K23 AG031323-03/AG/NIA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110625
PL  - United States
TA  - J Gen Intern Med
JT  - Journal of general internal medicine
JID - 8605834
SB  - IM
CIN - J Gen Intern Med. 2012 Apr;27(4):403; author reply 404. PMID: 22311332
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Cohort Studies
MH  - Female
MH  - *Health Surveys/methods
MH  - Humans
MH  - Internet/*ethics
MH  - Internship and Residency/ethics
MH  - Male
MH  - Middle Aged
MH  - Physician-Patient Relations/*ethics
MH  - Physicians/ethics/psychology
MH  - *Social Networking
MH  - United States
MH  - Young Adult
PMC - PMC3181288
EDAT- 2011/06/28 06:00
MHDA- 2012/02/09 06:00
CRDT- 2011/06/28 06:00
PHST- 2010/11/05 00:00 [received]
PHST- 2011/05/27 00:00 [accepted]
PHST- 2011/04/25 00:00 [revised]
PHST- 2011/06/28 06:00 [entrez]
PHST- 2011/06/28 06:00 [pubmed]
PHST- 2012/02/09 06:00 [medline]
AID - 10.1007/s11606-011-1761-2 [doi]
PST - ppublish
SO  - J Gen Intern Med. 2011 Oct;26(10):1168-74. doi: 10.1007/s11606-011-1761-2. Epub
      2011 Jun 25.


PMID- 21706192
OWN - NLM
STAT- MEDLINE
DCOM- 20120301
LR  - 20211020
IS  - 1863-4362 (Electronic)
IS  - 0021-1265 (Linking)
VI  - 180
IP  - 4
DP  - 2011 Dec
TI  - Warfarin anticoagulation: a survey of patients' knowledge of their treatment.
PG  - 819-22
LID - 10.1007/s11845-011-0726-0 [doi]
AB  - INTRODUCTION: Warfarin is used for the treatment of thromboembolic disease. It
      requires careful and sustained monitoring due to its narrow therapeutic index and
      potentially life-threatening complications. Patient education and knowledge is,
      therefore, vital. AIMS: To assess, in a specialised anticoagulation clinic, the
      extent of patients' knowledge of their warfarin treatment. METHODS: Ethical
      approval was obtained. All patients, aged over 18 years, attending our
      anticoagulation clinic during our study period were asked to participate.
      RESULTS: We enrolled 181 patients, 47.9% of respondents were unaware of any
      potential drug interactions, 57.7% of patients were unaware of any potential side
      effects, 20% of patients had experienced side effects, 10.9% of patients had been
      hospitalised due to side effects, 58% of which were due to Haemorrhage and 79% of
      patients kept a personal record of their INR. CONCLUSIONS: Patients'
      understanding of warfarin treatment was poor, despite their high level of
      compliance.
FAU - Moran, S M
AU  - Moran SM
AD  - Department of Cardiology, Mercy University Hospital, Grenville Place, Cork,
      Ireland. moransarah@gmail.com
FAU - Fitzgerald, N
AU  - Fitzgerald N
FAU - Pope, M
AU  - Pope M
FAU - Madden, M
AU  - Madden M
FAU - Vaughan, C J
AU  - Vaughan CJ
LA  - eng
PT  - Journal Article
DEP - 20110625
PL  - Ireland
TA  - Ir J Med Sci
JT  - Irish journal of medical science
JID - 7806864
RN  - 0 (Anticoagulants)
RN  - 5Q7ZVV76EI (Warfarin)
SB  - IM
CIN - Ir J Med Sci. 2013 Mar;182(1):153-4. PMID: 23115023
MH  - Aged
MH  - Aged, 80 and over
MH  - Anticoagulants/adverse effects/*therapeutic use
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Male
MH  - Medication Adherence
MH  - Middle Aged
MH  - Patient Education as Topic
MH  - Surveys and Questionnaires
MH  - Warfarin/adverse effects/*therapeutic use
EDAT- 2011/06/28 06:00
MHDA- 2012/03/02 06:00
CRDT- 2011/06/28 06:00
PHST- 2010/09/06 00:00 [received]
PHST- 2011/06/08 00:00 [accepted]
PHST- 2011/06/28 06:00 [entrez]
PHST- 2011/06/28 06:00 [pubmed]
PHST- 2012/03/02 06:00 [medline]
AID - 10.1007/s11845-011-0726-0 [doi]
PST - ppublish
SO  - Ir J Med Sci. 2011 Dec;180(4):819-22. doi: 10.1007/s11845-011-0726-0. Epub 2011
      Jun 25.


PMID- 21706183
OWN - NLM
STAT- MEDLINE
DCOM- 20110929
LR  - 20211020
IS  - 1432-1203 (Electronic)
IS  - 0340-6717 (Linking)
VI  - 130
IP  - 3
DP  - 2011 Sep
TI  - Genomic databases access agreements: legal validity and possible sanctions.
PG  - 441-9
LID - 10.1007/s00439-011-1044-3 [doi]
AB  - Large-scale, public genomic databases have greatly improved the capacity of
      researchers to do genomic research. In order to ensure that the scientific
      community uses data from these public resources properly, data access agreements 
      have been developed to complement already existing legal and ethical norms.
      Sanctions to address cases of data misuse constitute an essential part of this
      compliance framework meant to protect stakeholders in genomic research. Yet very 
      little research and community debate has been done on this most important topic. 
      This paper presents a review of different sanctions that could be invoked in
      cases of non-compliance from data users. They have been identified through
      comprehensive research and analysis of over 450 documents (journal articles,
      policy, guidelines, access policies, etc.) related to this topic. Given the
      considerable impact on users of even the milder sanctions considered in our
      paper, it is essential that stakeholders strive to achieve the highest degree of 
      standardization and transparency when designing controlled-access agreements. It 
      is only fair, after all, that users be able to expect that the border between
      acceptable and unacceptable conduct is clearly delineated and predictable in
      controlled-access policies. This suggests the importance for researchers to
      undertake additional empirical studies on the clarity and accessibility of
      existing database access agreements and related policies in the near future.
FAU - Joly, Yann
AU  - Joly Y
AD  - Deptartment of Human Genetics, Faculty of Medicine, Centre of Genomics and
      Policy, McGill University, 740 Dr. Penfield Avenue, Suite 5101, Montreal, QC H3A 
      1A4, Canada. yann.joly@mail.mcgill.ca
FAU - Zeps, Nik
AU  - Zeps N
FAU - Knoppers, Bartha M
AU  - Knoppers BM
LA  - eng
PT  - Journal Article
DEP - 20110625
PL  - Germany
TA  - Hum Genet
JT  - Human genetics
JID - 7613873
SB  - IM
MH  - *Access to Information/legislation & jurisprudence
MH  - Behavior Control
MH  - Biological Specimen Banks
MH  - Community-Institutional Relations
MH  - *Consent Forms
MH  - Databases, Genetic/*legislation & jurisprudence/*standards
MH  - Humans
MH  - Policy
EDAT- 2011/06/28 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/06/28 06:00
PHST- 2011/05/05 00:00 [received]
PHST- 2011/06/12 00:00 [accepted]
PHST- 2011/06/28 06:00 [entrez]
PHST- 2011/06/28 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - 10.1007/s00439-011-1044-3 [doi]
PST - ppublish
SO  - Hum Genet. 2011 Sep;130(3):441-9. doi: 10.1007/s00439-011-1044-3. Epub 2011 Jun
      25.


PMID- 21706182
OWN - NLM
STAT- MEDLINE
DCOM- 20110929
LR  - 20211020
IS  - 1432-1203 (Electronic)
IS  - 0340-6717 (Linking)
VI  - 130
IP  - 3
DP  - 2011 Sep
TI  - Biobanking and deceased persons.
PG  - 415-23
LID - 10.1007/s00439-011-1049-y [doi]
AB  - Early biomedical research focused primarily on the study of specific diseases or 
      sets of diseases within small groups of living research participants.
      Accordingly, the first ethical frameworks governing biomedical research addressed
      short-term, limited-scope research involving living research participants. Due to
      recent interest in longitudinal population studies and biobanking, research is
      increasingly long term. This shift raises several ethical and legal issues
      concerning the impact of a participant's death on research. This paper offers an 
      overview of these issues in the context of longitudinal biobanking genetic
      research. Our first part outlines the legal and ethical frameworks that govern
      the effect of the participants' death on consent. This will be followed by an
      analysis of the legal and ethical frameworks that govern the secondary use of
      deceased participants' data and samples and the return of deceased participants' 
      individual research results to biological family members. In our second part, we 
      will review the current literature and discuss the above mentioned issues using
      the bioethics "principlism" theory before concluding.
FAU - Tasse, Anne Marie
AU  - Tasse AM
AD  - McGill University, 740, Dr Penfield Ave. suite 5202, Montreal, QC H3A 1A4,
      Canada. anne-marie.tasse@mcgill.ca
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110625
PL  - Germany
TA  - Hum Genet
JT  - Human genetics
JID - 7613873
SB  - IM
MH  - Biological Specimen Banks/*ethics/legislation & jurisprudence
MH  - Biomedical Research/ethics
MH  - *Death
MH  - Genetic Research/*ethics/legislation & jurisprudence
MH  - Guidelines as Topic
MH  - Humans
MH  - Informed Consent
MH  - International Cooperation
MH  - Longitudinal Studies
MH  - *Research Subjects/legislation & jurisprudence
EDAT- 2011/06/28 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/06/28 06:00
PHST- 2011/04/21 00:00 [received]
PHST- 2011/06/19 00:00 [accepted]
PHST- 2011/06/28 06:00 [entrez]
PHST- 2011/06/28 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - 10.1007/s00439-011-1049-y [doi]
PST - ppublish
SO  - Hum Genet. 2011 Sep;130(3):415-23. doi: 10.1007/s00439-011-1049-y. Epub 2011 Jun 
      25.


PMID- 21705347
OWN - NLM
STAT- MEDLINE
DCOM- 20120301
LR  - 20120910
IS  - 1471-8391 (Electronic)
IS  - 0007-1420 (Linking)
VI  - 99
DP  - 2011
TI  - Next generation sequencing--implications for clinical practice.
PG  - 53-71
LID - 10.1093/bmb/ldr029 [doi]
AB  - BACKGROUND: Genetic testing in inherited disease has traditionally relied upon
      recognition of the presenting clinical syndrome and targeted analysis of genes
      known to be linked to that syndrome. Consequently, many patients with genetic
      syndromes remain without a specific diagnosis. AREAS OF AGREEMENT: New
      'next-generation' sequencing (NGS) techniques permit simultaneous sequencing of
      enormous amounts of DNA. A slew of research publications have recently
      demonstrated the tremendous power of these technologies in increasing
      understanding of human genetic disease. AREAS OF CONTROVERSY: These approaches
      are likely to be increasingly employed in routine diagnostic practice, but the
      scale of the genetic information yielded about individuals means that caution
      must be exercised to avoid net harm in this setting. AREAS TIMELY FOR DEVELOPING 
      RESEARCH: Use of NGS in a research setting will increasingly have a major but
      indirect beneficial impact on clinical practice. However, important technical,
      ethical and social challenges need to be addressed through informed professional 
      and public dialogue before it finds its mature niche as a direct tool in the
      clinical diagnostic armoury.
FAU - Raffan, Eleanor
AU  - Raffan E
AD  - Metabolic Research Laboratories, Institute of Metabolic Science, University of
      Cambridge, Box 289, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.
FAU - Semple, Robert K
AU  - Semple RK
LA  - eng
GR  - 080952/Z/06/Z/Wellcome Trust/United Kingdom
GR  - 087678/Z/08/Z/Wellcome Trust/United Kingdom
GR  - Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110623
PL  - England
TA  - Br Med Bull
JT  - British medical bulletin
JID - 0376542
SB  - IM
MH  - *Ethics, Clinical
MH  - Exome/genetics
MH  - Forecasting
MH  - *Genetic Counseling/ethics/trends
MH  - *Genetic Diseases, Inborn/diagnosis/physiopathology/prevention & control
MH  - Genetic Enhancement/*methods
MH  - Genetic Research/ethics
MH  - Genetic Testing/methods/*trends
MH  - High-Throughput Nucleotide Sequencing/methods/trends
MH  - Humans
MH  - Inheritance Patterns/genetics
MH  - Medical Laboratory Science/methods/trends
MH  - Sequence Analysis, DNA/*methods
EDAT- 2011/06/28 06:00
MHDA- 2012/03/02 06:00
CRDT- 2011/06/28 06:00
PHST- 2011/06/28 06:00 [entrez]
PHST- 2011/06/28 06:00 [pubmed]
PHST- 2012/03/02 06:00 [medline]
AID - ldr029 [pii]
AID - 10.1093/bmb/ldr029 [doi]
PST - ppublish
SO  - Br Med Bull. 2011;99:53-71. doi: 10.1093/bmb/ldr029. Epub 2011 Jun 23.


PMID- 21705242
OWN - NLM
STAT- MEDLINE
DCOM- 20111102
LR  - 20131121
IS  - 1879-1190 (Electronic)
IS  - 1072-7515 (Linking)
VI  - 213
IP  - 3
DP  - 2011 Sep
TI  - Effect of repetitive loading on the mechanical properties of synthetic hernia
      repair materials.
PG  - 430-5
LID - 10.1016/j.jamcollsurg.2011.05.018 [doi]
AB  - BACKGROUND: Hernia repair materials undergo repeated loading while in the body,
      and the impact on mechanical properties is unknown. It was hypothesized that
      exposure to repetitive loading would lead to decreased tensile strength and
      increased strain, and that these differences would become more pronounced with
      greater loading and unloading sequences. STUDY DESIGN: Polypropylene, expanded
      polytetrafluoroethylene, composite barrier, and partially absorbable meshes were 
      evaluated. Twenty specimens (7.5 x 7.5 cm) were prepared from each material. Five
      specimens were subjected to ball burst testing to determine baseline
      biomechanical properties. Cycles of 10, 100, and 1,000 loading sequences were
      also performed (n = 5 each). RESULTS: BardMesh (CR Bard/Davol), Dualmesh (WL
      Gore), and Prolene (Ethicon) exhibited significantly reduced tensile strength;
      BardMesh, Proceed (Ethicon), Prolene, ProLite (Atrium Medical), ProLite Ultra
      (Atrium Medical), and Ultrapro (Ethicon) exhibited significantly increased strain
      after exposure to 1,000 cycles compared with their baseline properties. BardMesh 
      and Prolene demonstrated both reduced tensile strength and increased strain
      values after 1,000 cycles, suggesting that repetitive loading has the greatest
      effects on these materials. In addition, BardMesh and Prolene exhibited
      progressively worsening effects as the number of cycles was increased.
      CONCLUSIONS: Deterioration of the tensile strength of the mesh or an increase in 
      the ability of the mesh material to stretch (ie, increased strain values) could
      potentially lead to hernia recurrence or a poor functional result. However, the
      results of this study should not be interpreted to mean that hernia repair
      materials will fail in the body after only 10, 100, or 1,000 cycles. The
      conditions used in this study were more extreme than most physiologic scenarios
      and were intended as a pilot investigation into how the mechanical properties of 
      hernia repair materials are affected by in vitro cyclic testing.
CI  - Copyright (c) 2011 American College of Surgeons. Published by Elsevier Inc. All
      rights reserved.
FAU - Eliason, Braden J
AU  - Eliason BJ
AD  - Department of Surgery, Section of Minimally Invasive Surgery, Washington
      University School of Medicine, St Louis, MO, USA.
FAU - Frisella, Margaret M
AU  - Frisella MM
FAU - Matthews, Brent D
AU  - Matthews BD
FAU - Deeken, Corey R
AU  - Deeken CR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110625
PL  - United States
TA  - J Am Coll Surg
JT  - Journal of the American College of Surgeons
JID - 9431305
RN  - 0 (Polypropylenes)
RN  - 9002-84-0 (Polytetrafluoroethylene)
SB  - IM
MH  - Absorbable Implants
MH  - Analysis of Variance
MH  - Biomechanical Phenomena
MH  - *Herniorrhaphy
MH  - Humans
MH  - Materials Testing
MH  - Polypropylenes
MH  - Polytetrafluoroethylene
MH  - *Surgical Mesh
MH  - Tensile Strength
EDAT- 2011/06/28 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/06/28 06:00
PHST- 2011/04/13 00:00 [received]
PHST- 2011/05/25 00:00 [revised]
PHST- 2011/05/26 00:00 [accepted]
PHST- 2011/06/28 06:00 [entrez]
PHST- 2011/06/28 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
AID - S1072-7515(11)00402-9 [pii]
AID - 10.1016/j.jamcollsurg.2011.05.018 [doi]
PST - ppublish
SO  - J Am Coll Surg. 2011 Sep;213(3):430-5. doi: 10.1016/j.jamcollsurg.2011.05.018.
      Epub 2011 Jun 25.


PMID- 21704911
OWN - NLM
STAT- MEDLINE
DCOM- 20110830
LR  - 20160519
IS  - 1878-8769 (Electronic)
IS  - 1878-8750 (Linking)
VI  - 75
IP  - 5-6
DP  - 2011 May-Jun
TI  - Predictors of functional recovery in African patients with traumatic intracranial
      hematomas.
PG  - 586-91
LID - 10.1016/j.wneu.2010.05.041 [doi]
AB  - BACKGROUND: Head injury is a critical public health problem responsible for up to
      50% of fatalities among trauma patients and for a large component of continuing
      care among survivors. Intracranial hematomas are among the most common clinical
      entities encountered by any neurosurgical service and have a very high mortality 
      rate and extremely poor prognosis among traumatic brain injuries. OBJECTIVE: The 
      purpose of this study was to investigate reliable factors influencing the
      functional outcome of the patients with traumatic intracranial hematomas (ICHs). 
      METHODS: A retrospective analysis was conducted of consecutive patients
      presenting at the Kenyatta National Hospital between January 2000 and December
      2009. Following ethical approval, the records of patients admitted to the
      neurosurgical unit and diagnosed with traumatic ICH were retrieved and reviewed. 
      The outcome measure was the Glasgow Outcome Scale (GOS) score at discharge. Data 
      were collected in preformed questionnaires, and the coding and analysis were
      carried out using SPSS, version 11.5. RESULTS: Of the 608 patients diagnosed with
      intracranial hematomas during the study period, there was a clear male
      predominance, with 89.3% male and 10.7% female patients. Majority of the patients
      (49%) were aged between 26 and 45 years, whereas 5.6% and 9.4% were younger than 
      age 13 years and older than age 61 years, respectively. The most common cause of 
      injury was assault (48%). Good functional recovery was achieved by 280 (46.1%) of
      the patients in our series, whereas moderate and severe disability accounted for 
      27% and 6.9%, respectively. Males were more likely to have functional recovery
      (46.4%) than were females (43.1%), though this finding was not statistically
      significant (P = 0.069). The proportion of patients who achieved functional
      recovery seemed to decrease with increasing age. Patients who were involved in
      motor vehicle accidents were less likely to have functional recovery (33.7%, P = 
      0.003) than those who fell (53.6%). There was a statistically significant
      difference in the proportion of patients who achieved functional recovery, with
      65.2% of those who had mild head injury as compared to 46% and 15.1% (P </=
      0.001) for those with moderate and severe head injury, respectively. Patients who
      had surgical intervention were more likely to achieve functional outcome (51.2%) 
      as compared to 31.7% in those managed conservatively. Furthermore, the time
      elapsed from initial trauma to surgery significantly influenced outcome. The type
      of surgery done was not found to significantly influence patient outcome (P =
      0.095). CONCLUSION: An increased risk of poor outcome occurs in patients who are 
      older than age 61 years, have lower preoperative GCS scores, pupillary
      abnormalities, and a long interval between trauma and decompression. The findings
      would help clinicians determine management criteria and improve survival.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Kiboi, Julius G
AU  - Kiboi JG
AD  - Department of Neurosurgery, University of Nairobi, Nairobi, Kenya.
      j_kiboi@yahoo.com
FAU - Kitunguu, Peter K
AU  - Kitunguu PK
FAU - Angwenyi, Phillip
AU  - Angwenyi P
FAU - Mbuthia, Fred
AU  - Mbuthia F
FAU - Sagina, Laura S
AU  - Sagina LS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World Neurosurg
JT  - World neurosurgery
JID - 101528275
SB  - IM
MH  - Accidents, Traffic/statistics & numerical data
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Blood Pressure/physiology
MH  - Brain Hemorrhage, Traumatic/epidemiology/*therapy
MH  - Child
MH  - Child, Preschool
MH  - Data Interpretation, Statistical
MH  - Disability Evaluation
MH  - Female
MH  - Glasgow Coma Scale
MH  - Glasgow Outcome Scale
MH  - Hematoma, Epidural, Cranial/epidemiology/therapy
MH  - Hematoma, Subdural/epidemiology/therapy
MH  - Humans
MH  - Infant
MH  - Kenya/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Pupil/physiology
MH  - Recovery of Function
MH  - Referral and Consultation
MH  - Sex Factors
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2011/06/28 06:00
MHDA- 2011/08/31 06:00
CRDT- 2011/06/28 06:00
PHST- 2010/05/12 00:00 [received]
PHST- 2010/05/17 00:00 [accepted]
PHST- 2011/06/28 06:00 [entrez]
PHST- 2011/06/28 06:00 [pubmed]
PHST- 2011/08/31 06:00 [medline]
AID - S1878-8750(10)00243-3 [pii]
AID - 10.1016/j.wneu.2010.05.041 [doi]
PST - ppublish
SO  - World Neurosurg. 2011 May-Jun;75(5-6):586-91. doi: 10.1016/j.wneu.2010.05.041.


PMID- 21703648
OWN - NLM
STAT- MEDLINE
DCOM- 20120927
LR  - 20220318
IS  - 1873-7064 (Electronic)
IS  - 0028-3908 (Linking)
VI  - 62
IP  - 3
DP  - 2012 Mar
TI  - Tracing the development of psychosis and its prevention: what can be learned from
      animal models.
PG  - 1273-89
LID - 10.1016/j.neuropharm.2011.04.019 [doi]
AB  - Schizophrenia (SCZ) is a neurodevelopmental disorder manifested symptomatically
      after puberty whose pharmacotherapy remains unsatisfactory. In recent years,
      longitudinal structural neuroimaging studies have revealed that neuroanatomical
      aberrations occur in this disorder and in fact precede symptom onset, raising the
      exciting possibility that SCZ can be prevented. There is some evidence that
      treatment with atypical antipsychotic drugs (APDs) prior to the development of
      the full clinical phenotype reduces the risk of transition to psychosis, but
      results remain controversial. It remains unknown whether progressive structural
      brain aberrations can be halted. Given the diagnostic, ethical, clinical and
      methodological problems of pharmacological and imaging studies in patients,
      getting such information remains a major challenge. Animal neurodevelopmental
      models of SCZ are invaluable for investigating such questions because they
      capture the notion that the effects of early brain damage are progressive. In
      recent years, data derived from such models have converged on key
      neuropathological and behavioral deficits documented in SCZ attesting to their
      strong validity, and making them ideal tools for evaluating progression of
      pathology following in-utero insults as well as its prevention. We review here
      our recent studies that use longitudinal in vivo structural imaging to achieve
      this aim in the prenatal immune stimulation model that is based on the
      association of prenatal infection and increased risk for SCZ. Pregnant rats were 
      injected on gestational day 15 with the viral mimic
      polyriboinosinic-polyribocytidylic acid (poly I:C) or saline. Male and female
      offspring were imaged and tested behaviorally on postnatal days (PNDs) 35, 46,
      56, 70 and 90. In other experiments, offspring of poly I:C- and saline-treated
      dams received the atypical antipsychotic drugs (APDs) clozapine or risperidone in
      two developmental windows: PND 34-47 and PND 48-61, and underwent behavioral
      testing and imaging at adulthood. Prenatal poly I:C-induced interference with
      fetal brain development led to aberrant postnatal brain development as manifested
      in structural abnormalities in the hippocampus, the striatum, the prefrontal
      cortex and lateral ventricles (LV), as seen in SCZ. The specific trajectories
      were region-, age- and sex-specific, with females having delayed onset of
      pathology compared to males. Brain pathology was accompanied by development of
      behavioral abnormalities phenotypic of SCZ, attentional deficit and
      hypersensitivity to amphetamine, with same sex difference. Hippocampal volume
      loss and LV volume expansion as well as behavioral abnormalities were prevented
      in the offspring of poly I:C mothers who received clozapine or risperidone during
      the asymptomatic period of adolescence (PND 34-47). Administration at a later
      window, PNDs 48-61, exerted sex-, region- and drug- specific effects. Our data
      show that prenatal insult leads to progressive postnatal brain pathology, which
      gradually gives rise to "symptoms"; that treatment with atypical APDs can prevent
      both brain and behavioral pathology; and that the earlier the intervention, the
      more pathological outcomes can be prevented.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Piontkewitz, Yael
AU  - Piontkewitz Y
AD  - Department of Psychology, Tel-Aviv University, Ramat Aviv, Tel-Aviv 69978,
      Israel.
FAU - Arad, Michal
AU  - Arad M
FAU - Weiner, Ina
AU  - Weiner I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20110623
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - *Disease Models, Animal
MH  - Early Diagnosis
MH  - Female
MH  - Hippocampus/*pathology
MH  - Humans
MH  - Male
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*physiopathology
MH  - Psychotic Disorders/diagnosis/*etiology/*prevention & control
MH  - Rats
EDAT- 2011/06/28 06:00
MHDA- 2012/09/28 06:00
CRDT- 2011/06/28 06:00
PHST- 2011/01/09 00:00 [received]
PHST- 2011/04/13 00:00 [revised]
PHST- 2011/04/15 00:00 [accepted]
PHST- 2011/06/28 06:00 [entrez]
PHST- 2011/06/28 06:00 [pubmed]
PHST- 2012/09/28 06:00 [medline]
AID - S0028-3908(11)00164-X [pii]
AID - 10.1016/j.neuropharm.2011.04.019 [doi]
PST - ppublish
SO  - Neuropharmacology. 2012 Mar;62(3):1273-89. doi: 10.1016/j.neuropharm.2011.04.019.
      Epub 2011 Jun 23.


PMID- 21702949
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1478-4505 (Electronic)
IS  - 1478-4505 (Linking)
VI  - 9
DP  - 2011 Jun 24
TI  - The evolution of health policy guidelines for assisted reproduction in the
      Republic of Ireland, 2004-2009.
PG  - 28
LID - 10.1186/1478-4505-9-28 [doi]
AB  - This analysis reports on Irish regulatory policies for in vitro fertilisation
      (IVF) from 2004-2009, in the context of membership changes within the Medical
      Council of Ireland. To achieve this, the current (2009) edition of the Guide to
      Professional Conduct & Ethics was compared with the immediately preceding version
      (2004). The statutory composition of the Medical Council from 2004-2009 was also 
      studied. Content analysis of the two editions identified the following
      differences: 1) The 2004 guide states that IVF "should only be used after
      thorough investigation has failed to reveal a treatable cause of the
      infertility", while the 2009 guide indicates IVF "should only be used after
      thorough investigation has shown that no other treatment is likely to be
      effective"; 2) The 2004 stipulation stating that fertilized ovum (embryo) "must
      be used for normal implantation and must not be deliberately destroyed" is absent
      from the 2009 guidelines; 3) The option to donate "unused fertilised ova"
      (embryos) is omitted from the 2009 guidelines; 4) The 2009 guidelines state that 
      ART should be offered only by "suitably qualified professionals, in appropriate
      facilities, and according to the international best practice"; 5) The 2009
      guidelines introduce criteria that donations as part of a donor programme should 
      be "altruistic and non-commercial". These last two points represent original
      regulatory efforts not appearing in the 2004 edition. The Medical Practitioners
      Act 2007 reduced the number of physicians on the Medical Council to 6 (of 25)
      members. The ethical guidelines from 2004 preceded this change, while the
      reconstituted Medical Council published the 2009 version. Between 2004 and 2009, 
      substantial modifications in reproductive health policy were incorporated into
      the Medical Council's ethical guidelines. The absence of controlling Irish
      legislation means that patients and IVF providers in Ireland must rely upon these
      guidelines by default. Our critique traces the evolution of public policy on IVF 
      during a time when the membership of the Medical Council changed radically;
      reduced physician contribution to decision-making was associated with diminished 
      protection for IVF-derived embryos in Ireland. Considerable uncertainty on IVF
      practice in Ireland remains.
FAU - Walsh, David J
AU  - Walsh DJ
AD  - Division of Reproductive Endocrinology & Infertility, The Sims Institute-Sims
      IVF/Department of Obstetrics & Gynaecology, School of Medicine, Royal College of 
      Surgeons in Ireland; Dublin, Ireland. drscottsills@sims.ie.
FAU - Ma, Mary L
AU  - Ma ML
FAU - Sills, Eric Scott
AU  - Sills ES
LA  - eng
PT  - Editorial
DEP - 20110624
PL  - England
TA  - Health Res Policy Syst
JT  - Health research policy and systems
JID - 101170481
PMC - PMC3141788
EDAT- 2011/06/28 06:00
MHDA- 2011/06/28 06:01
CRDT- 2011/06/28 06:00
PHST- 2011/04/21 00:00 [received]
PHST- 2011/06/24 00:00 [accepted]
PHST- 2011/06/28 06:00 [entrez]
PHST- 2011/06/28 06:00 [pubmed]
PHST- 2011/06/28 06:01 [medline]
AID - 1478-4505-9-28 [pii]
AID - 10.1186/1478-4505-9-28 [doi]
PST - epublish
SO  - Health Res Policy Syst. 2011 Jun 24;9:28. doi: 10.1186/1478-4505-9-28.


PMID- 21702861
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20110811
IS  - 1365-2702 (Electronic)
IS  - 0962-1067 (Linking)
VI  - 20
IP  - 17-18
DP  - 2011 Sep
TI  - A randomised controlled clinical trial of repositioning, using the 30 degrees
      tilt, for the prevention of pressure ulcers.
PG  - 2633-44
LID - 10.1111/j.1365-2702.2011.03736.x [doi]
AB  - UNLABELLED: BACKGROUNDL: Pressure ulcers are common, costly and impact negatively
      on individuals. Pressure is the prime cause, and immobility is the factor that
      exposes individuals to pressure. International guidelines advocate repositioning;
      however, there is confusion surrounding the best method and frequency required.
      DESIGN: A pragmatic, multi-centre, open label, prospective, cluster-randomised
      controlled trial was conducted to compare the incidence of pressure ulcers among 
      older persons nursed using two different repositioning regimens. METHOD: Ethical 
      approval was received. Study sites (n=12) were allocated to study arm using
      cluster randomisation. The experimental group (n=99) were repositioned three
      hourly at night, using the 30 degrees tilt; the control group (n=114) received
      routine prevention (six-hourly repositioning, using 90 degrees lateral rotation).
      Data analysis was by intention to treat; follow-up was for four weeks. RESULTS:
      All participants (n=213) were Irish and white, among them 77% were women and 65% 
      aged 80 years or older. Three patients (3%) in the experimental group and 13
      patients (11%) in the control group developed a pressure ulcer (p=0.035; 95% CI
      0.031-0.038; ICC=0.001). All pressure ulcers were grade 1 (44%) or grade 2 (56%).
      Mobility and activity were the highest predictors of pressure ulcer development
      (beta=-0.246, 95% CI=-0.319 to -0.066; p=0.003); (beta=0.227, 95% CI=0.041-0.246;
      p = 0.006). CONCLUSION: Repositioning older persons at risk of pressure ulcers
      every three hours at night, using the 30 degrees tilt, reduces the incidence of
      pressure ulcers compared with usual care. The study supports the recommendations 
      of the 2009 international pressure ulcer prevention guidelines. RELEVANCE TO
      CLINICAL PRACTICE: An effective method of pressure ulcer prevention has been
      identified; in the light of the problem of pressures ulcers, current prevention
      strategies should be reviewed. It is important to implement appropriate
      prevention strategies, of which repositioning is one.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Moore, Zena
AU  - Moore Z
AD  - Faculty of Nursing & Midwifery, Royal College of Surgeons in Ireland.
      zmoore@rcsi.ie
FAU - Cowman, Seamus
AU  - Cowman S
FAU - Conroy, Ronan M
AU  - Conroy RM
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110627
PL  - England
TA  - J Clin Nurs
JT  - Journal of clinical nursing
JID - 9207302
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - Male
MH  - *Posture
MH  - Pressure Ulcer/*prevention & control
EDAT- 2011/06/28 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/06/28 06:00
PHST- 2011/06/28 06:00 [entrez]
PHST- 2011/06/28 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1111/j.1365-2702.2011.03736.x [doi]
PST - ppublish
SO  - J Clin Nurs. 2011 Sep;20(17-18):2633-44. doi: 10.1111/j.1365-2702.2011.03736.x.
      Epub 2011 Jun 27.


PMID- 21702639
OWN - NLM
STAT- MEDLINE
DCOM- 20111003
LR  - 20161125
IS  - 1445-6354 (Electronic)
IS  - 1445-6354 (Linking)
VI  - 11
IP  - 2
DP  - 2011
TI  - The use of Photovoice to document and characterize the food security of users of 
      community food programs in Iqaluit, Nunavut.
PG  - 1680
AB  - INTRODUCTION: Food insecurity is a chronic problem affecting Inuit communities.
      The most comprehensive assessment of Inuit food security to-date, the Inuit
      Health Survey, reported that 70% of Inuit pre-school children lived in 'food
      insecure' households. Food banks and soup kitchens are relatively new in the
      Arctic but the number of users is increasing. Little is known about the
      experience and determinants of food insecurity among food program users who are
      often among the most marginalized (socially and economically) in communities. The
      use of participatory research methods when working in the north of Canada can
      promote meaningful knowledge exchange with community members and this approach
      was used in the present 'Photovoice' research. Photovoice uses photography to
      develop a baseline understanding of an issue, in this case the experience and
      determinants of food insecurity among users of community food programs in
      Iqaluit, Nunavut. The target population includes those who face significant
      social and economic marginalization, an often neglected group in Arctic food
      systems research. METHODS: Eight regular users of food programs were recruited
      and engaged in a Photovoice research project to document factors determining
      their daily food consumption. The research method was introduced in workshops and
      discussion included the ethical concerns related to photography and how to take
      pictures. Participants were supplied with digital cameras, and asked to answer
      the following question using photography: 'What aspects of your everyday life
      affect what you eat and how much you have to eat?'. In the final workshop,
      photographs were discussed among the group and participants identified key themes
      in the photographs, offering an understanding of food insecurity from their
      perspectives. The group then discussed what should be done with the knowledge
      gained. RESULTS: Factors improving food security were the customary systems for
      sharing 'country food', and the presence of social support networks in the
      community, such as the Food Bank, the Soup Kitchen and the Tukisigiarvik Center. 
      Factors identified as negatively affecting food security were the high cost of
      food in the Arctic, and substance abuse. The participants decided by consensus
      whether and how the knowledge from this project would be disseminated. They
      decided that a museum exhibit of the photographs in the summer of 2010 and
      promotion of the results among policy-makers in Nunavut were of high priority.
      CONCLUSION: The use of participatory research approaches such as Photovoice
      offers promise for exploring food security issues among similarly disadvantaged
      and vulnerable populations elsewhere in the Arctic. This approach was found to be
      a useful method for gathering and sharing research data because the data was
      generated and analysed by the participants. The clear and concise messages
      developed by the participants can be used to inform policy. This research method 
      can assist in making a valuable contribution to health research, both in the
      Arctic and worldwide, because it promotes an understanding of the experiences of 
      individuals from their own perspective.
FAU - Lardeau, M-P
AU  - Lardeau MP
AD  - McGill University, Department of Geography, Montreal, Quebec, Canada.
      marie-pierre.lardeau@mail.mcgill.ca
FAU - Healey, G
AU  - Healey G
FAU - Ford, J
AU  - Ford J
LA  - eng
PT  - Journal Article
DEP - 20110621
PL  - Australia
TA  - Rural Remote Health
JT  - Rural and remote health
JID - 101174860
SB  - IM
MH  - Community Participation
MH  - *Diet/psychology
MH  - Female
MH  - Food Deprivation
MH  - *Food Supply/economics
MH  - Humans
MH  - Inuits/*psychology
MH  - Male
MH  - Narration
MH  - Nunavut
MH  - Photography
MH  - Social Support
MH  - Social Welfare/*psychology
EDAT- 2011/06/28 06:00
MHDA- 2011/10/04 06:00
CRDT- 2011/06/28 06:00
PHST- 2011/06/28 06:00 [entrez]
PHST- 2011/06/28 06:00 [pubmed]
PHST- 2011/10/04 06:00 [medline]
AID - 1680 [pii]
PST - ppublish
SO  - Rural Remote Health. 2011;11(2):1680. Epub 2011 Jun 21.


PMID- 21701955
OWN - NLM
STAT- MEDLINE
DCOM- 20120613
LR  - 20211020
IS  - 1573-3599 (Electronic)
IS  - 1059-7700 (Linking)
VI  - 21
IP  - 1
DP  - 2012 Feb
TI  - A survey of ethical and professional challenges experienced by Spanish
      health-care professionals that provide genetic counseling services.
PG  - 85-100
LID - 10.1007/s10897-011-9382-9 [doi]
AB  - Genetic testing is increasingly applied for diagnosis and clinical treatment. In 
      some countries, genetic counseling services are provided by professionals with
      specific training in this discipline, whereas other countries have no teaching
      programs and counseling is offered by physicians, nurses, pharmacists or
      biochemists. This counseling raises more and more ethical dilemmas for health
      professionals at their clinics. The purpose of this study was to analyze the
      characteristics of Spanish professionals devoted to providing genetic counseling 
      services and to investigate the frequency of the ethical dilemmas they face.
      Results from 72 survey respondents revealed this counseling is provided by an
      almost even number of male and female professionals, mostly physicians with many 
      years of professional experience. The overall frequency of the ethical dilemmas
      encountered was not high. The most frequent dilemmas corresponded to emotional
      responses by patients, informed consent, uncertainty about test results, and
      limitations on health-care resources. The frequency of dilemmas involving
      discrimination and provider directiveness was very low. Additional findings,
      practice implications, and research recommendations are presented.
FAU - Abad-Perotin, Reyes
AU  - Abad-Perotin R
AD  - Departamento de Ciencias Sanitarias y Medicosociales, Universidad de Alcala,
      Alcala de Henares, Madrid, Spain. reyes.abad@uah.es
FAU - Asunsolo-Del Barco, Angel
AU  - Asunsolo-Del Barco A
FAU - Silva-Mato, Agustin
AU  - Silva-Mato A
LA  - eng
PT  - Journal Article
DEP - 20110624
PL  - United States
TA  - J Genet Couns
JT  - Journal of genetic counseling
JID - 9206865
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Attitude of Health Personnel
MH  - Confidentiality
MH  - *Ethics, Clinical
MH  - Female
MH  - Genetic Counseling/*ethics
MH  - Genetic Testing/*ethics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Population Surveillance
MH  - Practice Patterns, Physicians'/*ethics
MH  - Professional-Family Relations/ethics
MH  - Professional-Patient Relations/*ethics
MH  - Social Support
MH  - Social Values
MH  - Spain
MH  - Surveys and Questionnaires
EDAT- 2011/06/28 06:00
MHDA- 2012/06/14 06:00
CRDT- 2011/06/25 06:00
PHST- 2010/10/10 00:00 [received]
PHST- 2011/06/07 00:00 [accepted]
PHST- 2011/06/25 06:00 [entrez]
PHST- 2011/06/28 06:00 [pubmed]
PHST- 2012/06/14 06:00 [medline]
AID - 10.1007/s10897-011-9382-9 [doi]
PST - ppublish
SO  - J Genet Couns. 2012 Feb;21(1):85-100. doi: 10.1007/s10897-011-9382-9. Epub 2011
      Jun 24.


PMID- 21701786
OWN - NLM
STAT- MEDLINE
DCOM- 20110823
LR  - 20211203
IS  - 1432-1203 (Electronic)
IS  - 0340-6717 (Linking)
VI  - 130
IP  - 1
DP  - 2011 Jul
TI  - Risk factors for autism: translating genomic discoveries into diagnostics.
PG  - 123-48
LID - 10.1007/s00439-011-1037-2 [doi]
AB  - Autism spectrum disorders (ASDs) are a group of conditions characterized by
      impairments in communication and reciprocal social interaction, and the presence 
      of restricted and repetitive behaviors. The spectrum of autistic features is
      variable, with severity of symptoms ranging from mild to severe, sometimes with
      poor clinical outcomes. Twin and family studies indicate a strong genetic basis
      for ASD susceptibility. Recent progress in defining rare highly penetrant
      mutations and copy number variations as ASD risk factors has prompted early
      uptake of these research findings into clinical diagnostics, with microarrays
      becoming a 'standard of care' test for any ASD diagnostic work-up. The
      ever-changing landscape of the generation of genomic data coupled with the vast
      heterogeneity in cause and expression of ASDs (further influenced by issues of
      penetrance, variable expressivity, multigenic inheritance and ascertainment)
      creates complexity that demands careful consideration of how to apply this
      knowledge. Here, we discuss the scientific, ethical, policy and communication
      aspects of translating the new discoveries into clinical and diagnostic tools for
      promoting the well-being of individuals and families with ASDs.
FAU - Scherer, Stephen W
AU  - Scherer SW
AD  - McLaughlin Centre and The Centre for Applied Genomics, The Hospital for Sick
      Children, Toronto, ON M5G 1L7, Canada. stephen.scherer@sickkids.ca
FAU - Dawson, Geraldine
AU  - Dawson G
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
GR  - Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110624
PL  - Germany
TA  - Hum Genet
JT  - Human genetics
JID - 7613873
SB  - IM
MH  - Autistic Disorder/diagnosis/genetics
MH  - Child
MH  - Child Development Disorders, Pervasive/diagnosis/*genetics
MH  - *DNA Copy Number Variations
MH  - Environment
MH  - *Health Policy
MH  - Humans
MH  - *Interdisciplinary Communication
MH  - Mutation
MH  - Risk Factors
MH  - Standard of Care
MH  - Translational Research, Biomedical
EDAT- 2011/06/28 06:00
MHDA- 2011/08/24 06:00
CRDT- 2011/06/25 06:00
PHST- 2011/05/07 00:00 [received]
PHST- 2011/06/06 00:00 [accepted]
PHST- 2011/06/25 06:00 [entrez]
PHST- 2011/06/28 06:00 [pubmed]
PHST- 2011/08/24 06:00 [medline]
AID - 10.1007/s00439-011-1037-2 [doi]
PST - ppublish
SO  - Hum Genet. 2011 Jul;130(1):123-48. doi: 10.1007/s00439-011-1037-2. Epub 2011 Jun 
      24.


PMID- 21701551
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111026
LR  - 20110624
IS  - 1476-5446 (Electronic)
IS  - 1462-0049 (Linking)
VI  - 12
IP  - 2
DP  - 2011
TI  - Quality of reporting randomised controlled trials in major dental journals
      suboptimal.
PG  - 52-3
LID - 10.1038/sj.ebd.6400796 [doi]
AB  - DATA SOURCES: Hand searching of the most recent 24 issues of six high impact
      dental journals. STUDY SELECTION: RCTs involving only humans, from 24 issues of
      six leading specialty journals, covering a period up to July 2009 were included, 
      including cluster randomised trials. DATA EXTRACTION AND SYNTHESIS: Each article 
      included in the study was assessed and scored independently by two observers,
      with any discrepancies being resolved by a third observer. In this study the
      modified CONSORT checklist was used to score each applicable item of data. The
      sum of the scores was converted to a percentage value for each trial. The data
      were analysed using descriptive statistics. Data regarding the publishing
      journal, country of origin of the trial, number of authors, involvement of
      statistician/epidemiologist, number of centres involved, ethics committee
      approval were subject to quantitative analysis. RESULTS: Ninety-five RCTs were
      identified with, according to the authors, generally suboptimal scores on quality
      reporting on key CONSORT areas. Significant differences in scores were found
      among the journals covering the named specialties. Overall there was a positive
      association between the quality score in studies with more authors, multicentre
      studies and studies in which a statistician/epidemiologist was involved.
      CONCLUSIONS: The overall quality of reporting RCTs in major dental journals was
      considered suboptimal in key CONSORT areas. This is very important as the
      reported results of RCTs can have an impact on future patient care.
FAU - Hurst, Dominic
AU  - Hurst D
AD  - Queen Mary University of London, Barts & The London School of Medicine and
      Dentistry, Institute of Dentistry, UK.
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - England
TA  - Evid Based Dent
JT  - Evidence-based dentistry
JID - 100883603
CON - J Dent. 2010 Sep;38(9):713-21. PMID: 20546823
EDAT- 2011/06/28 06:00
MHDA- 2011/06/28 06:01
CRDT- 2011/06/25 06:00
PHST- 2011/06/25 06:00 [entrez]
PHST- 2011/06/28 06:00 [pubmed]
PHST- 2011/06/28 06:01 [medline]
AID - 6400796 [pii]
AID - 10.1038/sj.ebd.6400796 [doi]
PST - ppublish
SO  - Evid Based Dent. 2011;12(2):52-3. doi: 10.1038/sj.ebd.6400796.


PMID- 21701455
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20181201
IS  - 1476-5373 (Electronic)
IS  - 0007-0610 (Linking)
VI  - 210
IP  - 12
DP  - 2011 Jun 24
TI  - Ethically unacceptable.
PG  - 558
LID - 10.1038/sj.bdj.2011.489 [doi]
FAU - Isaacson, K G
AU  - Isaacson KG
LA  - eng
PT  - Letter
PT  - Comment
DEP - 20110624
PL  - England
TA  - Br Dent J
JT  - British dental journal
JID - 7513219
SB  - IM
CON - Br Dent J. 2011 Apr 9;210(7):291-2. PMID: 21475257
MH  - Dentists/*ethics
MH  - *Ethics, Dental
MH  - Homeopathy/*ethics
MH  - Humans
EDAT- 2011/06/28 06:00
MHDA- 2011/11/09 06:00
CRDT- 2011/06/25 06:00
PHST- 2011/06/25 06:00 [entrez]
PHST- 2011/06/28 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - sj.bdj.2011.489 [pii]
AID - 10.1038/sj.bdj.2011.489 [doi]
PST - epublish
SO  - Br Dent J. 2011 Jun 24;210(12):558. doi: 10.1038/sj.bdj.2011.489.


PMID- 21700964
OWN - NLM
STAT- MEDLINE
DCOM- 20111031
LR  - 20181201
IS  - 1941-2444 (Electronic)
IS  - 0148-6071 (Linking)
VI  - 35
IP  - 4
DP  - 2011 Jul
TI  - Comment on Monod et al: "Ethical issues in nutrition support of severely disabled
      elderly persons".
PG  - 437-9; author reply 440-2
LID - 10.1177/0148607110394867 [doi]
FAU - Pepersack, Thierry
AU  - Pepersack T
LA  - eng
PT  - Letter
PT  - Comment
PL  - United States
TA  - JPEN J Parenter Enteral Nutr
JT  - JPEN. Journal of parenteral and enteral nutrition
JID - 7804134
SB  - IM
CON - JPEN J Parenter Enteral Nutr. 2011 May;35(3):295-302. PMID: 21527592
MH  - Aged
MH  - Disabled Persons
MH  - *Elder Nutritional Physiological Phenomena
MH  - Ethics, Medical
MH  - Humans
MH  - *Nutritional Support
EDAT- 2011/06/28 06:00
MHDA- 2011/11/01 06:00
CRDT- 2011/06/25 06:00
PHST- 2011/06/25 06:00 [entrez]
PHST- 2011/06/28 06:00 [pubmed]
PHST- 2011/11/01 06:00 [medline]
AID - 35/4/437 [pii]
AID - 10.1177/0148607110394867 [doi]
PST - ppublish
SO  - JPEN J Parenter Enteral Nutr. 2011 Jul;35(4):437-9; author reply 440-2. doi:
      10.1177/0148607110394867.


PMID- 21700724
OWN - NLM
STAT- MEDLINE
DCOM- 20120312
LR  - 20120514
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 12
DP  - 2011 Dec
TI  - Post-trial period surveillance for randomised controlled cardiovascular studies: 
      submitted protocols, consent forms and the role of the ethics board.
PG  - 762-5
LID - 10.1136/jme.2011.043349 [doi]
AB  - BACKGROUND: The post-trial period is the time period after the end of study drug 
      administration. It is unclear whether post-trial arrangements for patient
      surveillance are routinely included in study protocols and consents, and whether 
      research ethics boards (REB) consider the post-trial period. OBJECTIVES: The
      objective was to determine whether trial protocols and consent forms reviewed by 
      the REB describe procedures for post-trial period surveillance. METHODS: An
      observational study of protocols of randomised trials of chronic therapies for
      cardiac conditions, approved by the REB of two academic institutions affiliated
      with the University of Toronto in Canada (University Health Network and Mount
      Sinai Hospital) from 1995 to 2007. Plans for patient surveillance in the
      post-trial period described in the protocol or in the consent form before and
      after REB approval were recorded. RESULTS: 42 studies were identified including
      18 heart failure and 15 coronary artery disease trials. Only four studies planned
      a clinical visit after trial termination, and an additional three planned a
      telephone contact after trial completion. Five trials submitted consent forms to 
      the REB with a discussion of the post-trial period. CONCLUSIONS: The majority of 
      protocols and consent forms did not discuss plans for post-trial period
      surveillance. The post-trial period and the REB approval process could be
      improved by systematic follow-up being described in the protocol and consent
      form. The small number of trial protocols evaluated in the study may impair the
      degree to which the results can be generalised.
FAU - Zia, Mohammad I
AU  - Zia MI
AD  - Division of Cardiology, University of Toronto, Toronto, Canada.
      mo.zia@utoronto.ca
FAU - Heslegrave, Ronald
AU  - Heslegrave R
FAU - Newton, Gary E
AU  - Newton GE
LA  - eng
PT  - Journal Article
DEP - 20110623
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Cardiovascular Diseases/therapy
MH  - Chronic Disease/therapy
MH  - Clinical Protocols/*standards
MH  - Consent Forms
MH  - Ethics Committees, Research
MH  - Ethics, Research
MH  - *Follow-Up Studies
MH  - Humans
MH  - Monitoring, Physiologic/*standards
MH  - Observation/methods
MH  - Randomized Controlled Trials as Topic/*ethics
MH  - Research Design
EDAT- 2011/06/28 06:00
MHDA- 2012/03/13 06:00
CRDT- 2011/06/25 06:00
PHST- 2011/06/25 06:00 [entrez]
PHST- 2011/06/28 06:00 [pubmed]
PHST- 2012/03/13 06:00 [medline]
AID - jme.2011.043349 [pii]
AID - 10.1136/jme.2011.043349 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Dec;37(12):762-5. doi: 10.1136/jme.2011.043349. Epub 2011 Jun 
      23.


PMID- 21700552
OWN - NLM
STAT- MEDLINE
DCOM- 20110826
LR  - 20110711
IS  - 1769-6917 (Electronic)
IS  - 0007-4551 (Linking)
VI  - 98
IP  - 7
DP  - 2011 Jul
TI  - [Adjuvant chemotherapy for breast cancer and fertility: estimation of the impact,
      options of preservation and role of the oncologist].
PG  - 741-51
LID - 10.1684/bdc.2011.1391 [doi]
AB  - Fifty-two thousand new breast cancers occur each year in France, 7% in patients
      less than 40 years. The standard regimens of adjuvant chemotherapy for breast
      cancer now include anthracyclines and taxanes. These therapeutics advances have
      significantly improved the prognosis of these young women who may later wish to
      become mother and have biological offspring. The impact of chemotherapy on
      reproductive function should be accurately assessed and the ovarian reserve has
      to be taken into account. The estimated risk of chemo-induced amenorrhea and
      infertility has to be balanced with the expected results and risks of methods of 
      fertility preservation. The place of different options for fertility preservation
      depends on patient age, presence or not of a partner and the time available
      before the initiation of treatment. For these breast cancer patients who will
      receive chemotherapy, new techniques of in vitro oocyte maturation seem
      promising. Even if some ethical and technical issues are unresolved, fertility
      preservation must now be part of the management of these young patients receiving
      adjuvant chemotherapy for breast cancer. This new approach must be
      multidisciplinary and complex.
FAU - Mailliez, Audrey
AU  - Mailliez A
AD  - Centre Oscar-Lambret, departement de senologie, 3, rue Frederic-Combemale, 59020 
      Lille Cedex, France. a-mailliez@o-lambret.fr
FAU - Decanter, Christine
AU  - Decanter C
FAU - Bonneterre, Jacques
AU  - Bonneterre J
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Chimiotherapie adjuvante de cancer du sein et fertilite: estimation de l'impact, 
      options de preservation et place de l'oncologue.
PL  - France
TA  - Bull Cancer
JT  - Bulletin du cancer
JID - 0072416
RN  - 0 (Antineoplastic Agents)
RN  - 80497-65-0 (Anti-Mullerian Hormone)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Amenorrhea/chemically induced
MH  - Anti-Mullerian Hormone/deficiency
MH  - Antineoplastic Agents/adverse effects
MH  - Breast Neoplasms/*drug therapy
MH  - Chemotherapy, Adjuvant/adverse effects/methods
MH  - Cryopreservation
MH  - Female
MH  - Fertility/*drug effects
MH  - Humans
MH  - Infertility, Female/chemically induced/*prevention & control
MH  - Marital Status
MH  - Medical Oncology
MH  - Ovary/drug effects
MH  - Physician's Role
MH  - Practice Guidelines as Topic
MH  - Reproduction/drug effects
EDAT- 2011/06/28 06:00
MHDA- 2011/08/30 06:00
CRDT- 2011/06/25 06:00
PHST- 2011/06/25 06:00 [entrez]
PHST- 2011/06/28 06:00 [pubmed]
PHST- 2011/08/30 06:00 [medline]
AID - S0007-4551(15)30608-1 [pii]
AID - 10.1684/bdc.2011.1391 [doi]
PST - ppublish
SO  - Bull Cancer. 2011 Jul;98(7):741-51. doi: 10.1684/bdc.2011.1391.


PMID- 21699745
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111123
LR  - 20211020
IS  - 1756-994X (Electronic)
IS  - 1756-994X (Linking)
VI  - 3
IP  - 6
DP  - 2011 Jun 21
TI  - Exploring the ELSI universe: critical issues in the evolution of human genomic
      research.
PG  - 38
LID - 10.1186/gm254 [doi]
AB  - A report on the National Human Genome Research Institute's Ethical, Legal, and
      Social Implications Research Program 2011 Congress, 'Exploring the ELSI
      Universe', Chapel Hill, North Carolina, USA, 12-14 April 2011.
FAU - Oliver, Jill M
AU  - Oliver JM
AD  - Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston,
      TX 77030, USA. amcguire@bcm.edu.
FAU - McGuire, Amy L
AU  - McGuire AL
LA  - eng
PT  - Journal Article
DEP - 20110621
PL  - England
TA  - Genome Med
JT  - Genome medicine
JID - 101475844
PMC - PMC3218812
EDAT- 2011/06/28 06:00
MHDA- 2011/06/28 06:01
CRDT- 2011/06/25 06:00
PHST- 2011/06/25 06:00 [entrez]
PHST- 2011/06/28 06:00 [pubmed]
PHST- 2011/06/28 06:01 [medline]
AID - gm254 [pii]
AID - 10.1186/gm254 [doi]
PST - epublish
SO  - Genome Med. 2011 Jun 21;3(6):38. doi: 10.1186/gm254.


PMID- 21699716
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20211020
IS  - 1471-2377 (Electronic)
IS  - 1471-2377 (Linking)
VI  - 11
DP  - 2011 Jun 23
TI  - A prospective controlled study: minimally invasive stereotactic puncture therapy 
      versus conventional craniotomy in the treatment of acute intracerebral
      hemorrhage.
PG  - 76
LID - 10.1186/1471-2377-11-76 [doi]
AB  - BACKGROUND: Spontaneous intracerebral hemorrhage (ICH) is a devastating form of
      stroke with the high mortality twofold to sixfold higher than that for ischemic
      stroke. But the treatment of haematomas within the basal ganglia continues to be 
      a matter of debate among neurologists and neurosurgeons. The purpose of this
      study is to judge the clinical value of minimally invasive stereotactic puncture 
      therapy (MISPT) on acute ICH. METHODS: A prospective controlled study was
      undertaken. The clinical trial was in compliance with the WMA Declaration of
      Helsinki-Ethical Principles for Medical Research Involving Human Subjects.
      According to the enrollment criterion, there were 168 acute ICH cases analyzed,
      of which 90 cases were performed by MISPT (MISPT group, MG) and 78 cases by
      Conventional craniotomy (CC group, CG), by means of compare of Glasgow Coma Scale
      (GCS) score, postoperative complications (PC) and rebleeding incidence (RI),
      moreover, long-term outcome of 1 year postoperation judged by Glasgow Outcome
      Scale (GOS), Barthel Index (BI), modified Rankin Scale (mRS) and case
      fatality(CF). RESULTS: MG patients showed obvious amelioration in GCS score
      compared with that of CG. The total incidence of PC in MG decreased obviously
      compared with that of CG. The incidences of rebleeding in MG and CG were 10.0%
      and 15.4% respectively. There was no obvious difference between CFs of MG and CG.
      For three parameters representing long-term outcome, the GOS, BI and mRS in MG
      were ameliorated significantly than that of CG. CONCLUSION: These data suggested 
      that the advantage of MISPT was displayed in minute trauma and safety, and seemed
      to be feasible and to had a trend towards improved long-term outcome. TRIAL
      REGISTRATION: The Australian New Zealand Clinical Trials Registry (ANZCTR), the
      registration number: ACTRN12610000945022.
FAU - Zhou, Houguang
AU  - Zhou H
AD  - Department of Geriatrics, Huashan Hospital, Fudan University, Shanghai, China.
FAU - Zhang, Yu
AU  - Zhang Y
FAU - Liu, Ling
AU  - Liu L
FAU - Han, Xu
AU  - Han X
FAU - Tao, Yinghong
AU  - Tao Y
FAU - Tang, Yuping
AU  - Tang Y
FAU - Hua, Wei
AU  - Hua W
FAU - Xue, Jianzhong
AU  - Xue J
FAU - Dong, Qiang
AU  - Dong Q
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20110623
PL  - England
TA  - BMC Neurol
JT  - BMC neurology
JID - 100968555
SB  - IM
MH  - Cerebral Hemorrhage/*surgery
MH  - Craniotomy/adverse effects/*methods
MH  - Female
MH  - Glasgow Coma Scale
MH  - Glasgow Outcome Scale
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Minimally Invasive Surgical Procedures/adverse effects/*methods
MH  - Postoperative Complications/epidemiology
MH  - *Stereotaxic Techniques/adverse effects
PMC - PMC3142495
EDAT- 2011/06/28 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/06/25 06:00
PHST- 2010/10/24 00:00 [received]
PHST- 2011/06/23 00:00 [accepted]
PHST- 2011/06/25 06:00 [entrez]
PHST- 2011/06/28 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 1471-2377-11-76 [pii]
AID - 10.1186/1471-2377-11-76 [doi]
PST - epublish
SO  - BMC Neurol. 2011 Jun 23;11:76. doi: 10.1186/1471-2377-11-76.


PMID- 21699677
OWN - NLM
STAT- MEDLINE
DCOM- 20111114
LR  - 20211020
IS  - 1751-0147 (Electronic)
IS  - 0044-605X (Linking)
VI  - 53
DP  - 2011 Jun 23
TI  - Aspects of bovine herpesvirus-1 infection in dairy and beef herds in the Republic
      of Ireland.
PG  - 40
LID - 10.1186/1751-0147-53-40 [doi]
AB  - BACKGROUND: Infection with bovine herpesvirus-1 (BHV-1) causes a wide range of
      disease manifestations, including respiratory disease and abortion, with
      world-wide distribution. The primary objective of the present study was to
      describe aspects of BHV-1 infection and control on Irish farms, including
      herd-level seroprevalence (based on pooled sera) and vaccine usage. METHODS: The 
      characteristics of a diagnostic indirect BHV-1 antibody ELISA test when used on
      serum pools were evaluated using laboratory replicates for use in the
      seroprevalence study. The output from this indirect ELISA was expressed as a
      percentage positivity (PP) value. A proposed cut off (PCO) PP was applied in a
      cross-sectional study of a stratified random sample of 1,175 Irish dairy and beef
      cattle herds in 2009, using serum pools, to estimate herd seroprevalence. The
      study was observational, based primarily on the analysis of existing samples, and
      only aggregated results were reported. For these reasons, ethical approval was
      not required. Bulk milk samples from a subset of 111 dairy herds were analysed
      using the same ELISA. Information regarding vaccine usage was determined in a
      telephone survey. RESULTS: A PCO PP of 7.88% was determined to give 97.1%
      sensitivity and 100% specificity relative to the use of the ELISA on individual
      sera giving maximization of the prevalence independent Youden's index, on
      receiver operating characteristics analysis of replicate results. The herd-level 
      BHV-1 seroprevalence was 74.9% (95% CI - 69.9%-79.8%), with no significant
      difference between dairy and beef herds. 95.5% agreement in herd classification
      was found between bulk milk and serum pools. Only 1.8 percent of farmers used
      BHV-1 marker vaccine, 80% of which was live while 75% of vaccinated herds were
      dairy.A significant association was found between herd size (quartiles) and
      seroprevalence (quartiles). CONCLUSIONS: The results from this study indicate
      BHV-1 infection is endemic, although BHV-1 vaccines are rarely used, in the
      cattle population in Ireland.
FAU - Cowley, D J Bosco
AU  - Cowley DJ
AD  - MSD Animal Health, 4th Floor, Junction House, Airton Road, Tallaght, Dublin 24,
      Ireland. bosco.cowley@merck.com
FAU - Clegg, Tracy A
AU  - Clegg TA
FAU - Doherty, Michael L
AU  - Doherty ML
FAU - More, Simon J
AU  - More SJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110623
PL  - England
TA  - Acta Vet Scand
JT  - Acta veterinaria Scandinavica
JID - 0370400
RN  - 0 (Antibodies, Viral)
RN  - 0 (Herpesvirus Vaccines)
SB  - IM
MH  - Animals
MH  - Antibodies, Viral/*blood
MH  - Cattle
MH  - Cattle Diseases/*epidemiology/prevention & control/virology
MH  - Cross-Sectional Studies
MH  - Enzyme-Linked Immunosorbent Assay/veterinary
MH  - Female
MH  - Herpesviridae Infections/epidemiology/prevention & control/*veterinary
MH  - Herpesvirus 1, Bovine/*immunology
MH  - Herpesvirus Vaccines/*immunology
MH  - Ireland/epidemiology
MH  - Male
MH  - Milk/immunology/*virology
MH  - Sensitivity and Specificity
MH  - Seroepidemiologic Studies
MH  - Surveys and Questionnaires
PMC - PMC3141558
EDAT- 2011/06/28 06:00
MHDA- 2011/11/15 06:00
CRDT- 2011/06/25 06:00
PHST- 2010/11/26 00:00 [received]
PHST- 2011/06/23 00:00 [accepted]
PHST- 2011/06/25 06:00 [entrez]
PHST- 2011/06/28 06:00 [pubmed]
PHST- 2011/11/15 06:00 [medline]
AID - 1751-0147-53-40 [pii]
AID - 10.1186/1751-0147-53-40 [doi]
PST - epublish
SO  - Acta Vet Scand. 2011 Jun 23;53:40. doi: 10.1186/1751-0147-53-40.


PMID- 21699650
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20110714
IS  - 1526-4637 (Electronic)
IS  - 1526-2375 (Linking)
VI  - 12
IP  - 7
DP  - 2011 Jul
TI  - The business of pain medicine: the present mirrors antiquity.
PG  - 1063-75
LID - 10.1111/j.1526-4637.2011.01176.x [doi]
AB  - The practice of pain medicine is often considered a fledgling field, as are the
      economic, business, and related ethical issues associated with providing these
      services. This article first traces the history of pain care and its
      relationships to industry and business, as well as the impact of government
      regulations over the ages. The authors challenge the view that the commonly
      discussed health care issues facing pain medicine are new by tracing the business
      and regulatory-related antecedents of pain care practice from the first through
      21st century. The controversies associated with the practice of delivering
      pain-related health care services in an ethical manner are discussed with
      specific reference to the early work of clinicians, health care activists, and
      policy makers. The early activities of noteworthy individuals such as Pliny the
      Great, Hua T'o, John Locke, Benjamin Franklin, Oliver Wendell Holmes Sr., William
      Morton, Henry and William James, Heinrick Dresser, and other recent health care
      activists are reviewed. Issues of practitioner liability and regulatory
      restrictions on practice are also discussed in a historical context. The authors 
      conclude that familiar ethical dilemmas commonly arose in past centuries, and
      history may be repeating itself with respect to the concerns now being discussed 
      within our field. These arguments are reflected against the pain medicine Ethics 
      Charters of the American Academy of Pain Medicine throughout the document.
      Finally, we outline the challenges for the present and future. With an
      understanding of these eight historical events as a backdrop, we may be at an
      opportune time to better address these issues in a manner that could provide the 
      most effective pain care in our society.
CI  - Wiley Periodicals, Inc.
FAU - Kulich, Ronald
AU  - Kulich R
AD  - Craniofacial Pain and Headache Center, Tufts School of Medicine, Boston MA 02111,
      USA. rkulich@partners.org
FAU - Loeser, John D
AU  - Loeser JD
LA  - eng
PT  - Historical Article
PT  - Journal Article
DEP - 20110623
PL  - England
TA  - Pain Med
JT  - Pain medicine (Malden, Mass.)
JID - 100894201
SB  - IM
CIN - Pain Med. 2011 Jul;12(7):1060-2. PMID: 21752180
MH  - Analgesia/economics/*history/methods
MH  - Delivery of Health Care/*history/legislation & jurisprudence
MH  - Drug Industry
MH  - Ethics, Medical
MH  - Evidence-Based Medicine
MH  - Government Regulation
MH  - History, 18th Century
MH  - History, 19th Century
MH  - History, 20th Century
MH  - History, 21st Century
MH  - History, Ancient
MH  - History, Medieval
MH  - Humans
MH  - Pain/*drug therapy
EDAT- 2011/06/28 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/06/25 06:00
PHST- 2011/06/25 06:00 [entrez]
PHST- 2011/06/28 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - 10.1111/j.1526-4637.2011.01176.x [doi]
PST - ppublish
SO  - Pain Med. 2011 Jul;12(7):1063-75. doi: 10.1111/j.1526-4637.2011.01176.x. Epub
      2011 Jun 23.


PMID- 21684406
OWN - NLM
STAT- MEDLINE
DCOM- 20110824
LR  - 20220321
IS  - 1097-6760 (Electronic)
IS  - 0196-0644 (Linking)
VI  - 58
IP  - 1 Suppl 1
DP  - 2011 Jul
TI  - Ethical, financial, and legal considerations to implementing emergency department
      HIV screening: a report from the 2007 conference of the National Emergency
      Department HIV Testing Consortium.
PG  - S33-43
LID - 10.1016/j.annemergmed.2011.03.021 [doi]
AB  - OBJECTIVES: We seek to identify and analyze, from a group of participants
      experienced with HIV screening, the perceived challenges and solutions to the
      ethical, financial, and legal considerations of emergency department (ED)-based
      HIV screening. METHODS: We performed a qualitative analysis of the focus group
      discussions from the ethical, financial, and legal considerations portion of the 
      inaugural National Emergency Department HIV Testing Consortium conference. Four
      groups composed of 20 to 25 consortium participants engaged in semistructured,
      facilitated focus group discussions. The focus group discussions were audiotaped 
      and transcribed. A primary reader identified major themes and subthemes and
      representative quotes from the transcripts and summarized the discussions.
      Secondary and tertiary readers reviewed the themes, subthemes, and summaries for 
      accuracy. RESULTS: The focus group discussions centered on the following themes. 
      Ethical considerations included appropriateness of HIV screening in the ED and
      ethics of key elements of the 2006 Centers for Disease Control and Prevention HIV
      testing recommendations. Financial considerations included models of payment and 
      support, role of health care insurance, financial ethics and downstream financial
      burdens, and advocacy approaches. Legal considerations included the adequacy of
      obtaining consent, partner notification, disclosure of HIV results, difficulties 
      in addressing special populations, failure of not performing universal screening,
      failure to notify a person of being tested, failure to notify someone of their
      test results, liability of inaccurate tests, and failure to link to care.
      CONCLUSION: This qualitative analysis provides a broadly useful foundation to the
      ethical, financial, and legal considerations of implementing HIV screening
      programs in EDs throughout the United States.
CI  - Copyright (c) 2011. Published by Mosby, Inc.
FAU - Waxman, Michael J
AU  - Waxman MJ
AD  - Department of Emergency Medicine, Alpert Medical School of Brown University,
      Providence, RI, USA. mwaxman@hotmail.com
FAU - Popick, Rachel S
AU  - Popick RS
FAU - Merchant, Roland C
AU  - Merchant RC
FAU - Rothman, Richard E
AU  - Rothman RE
FAU - Shahan, Judy B
AU  - Shahan JB
FAU - Almond, Gregory
AU  - Almond G
LA  - eng
GR  - K23 A1060363/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ann Emerg Med
JT  - Annals of emergency medicine
JID - 8002646
SB  - IM
MH  - *AIDS Serodiagnosis/economics/ethics/legislation & jurisprudence
MH  - Contact Tracing/ethics/legislation & jurisprudence
MH  - Continuity of Patient Care
MH  - *Emergency Service, Hospital/economics/ethics/legislation & jurisprudence
MH  - Focus Groups
MH  - HIV Infections/diagnosis
MH  - Hospital Costs
MH  - Humans
MH  - Informed Consent/ethics/legislation & jurisprudence
MH  - Insurance Coverage
MH  - Mass Screening/economics/ethics/legislation & jurisprudence
MH  - Practice Guidelines as Topic
MH  - United States
EDAT- 2011/06/28 06:00
MHDA- 2011/08/25 06:00
CRDT- 2011/06/21 06:00
PHST- 2011/06/21 06:00 [entrez]
PHST- 2011/06/28 06:00 [pubmed]
PHST- 2011/08/25 06:00 [medline]
AID - S0196-0644(11)00255-1 [pii]
AID - 10.1016/j.annemergmed.2011.03.021 [doi]
PST - ppublish
SO  - Ann Emerg Med. 2011 Jul;58(1 Suppl 1):S33-43. doi:
      10.1016/j.annemergmed.2011.03.021.


PMID- 21698538
OWN - NLM
STAT- MEDLINE
DCOM- 20120117
LR  - 20160707
IS  - 1437-1588 (Electronic)
IS  - 1436-9990 (Linking)
VI  - 54
IP  - 7
DP  - 2011 Jul
TI  - [A comprehensive assessment of ATMP. Difficulties and approaches].
PG  - 843-8
LID - 10.1007/s00103-011-1300-7 [doi]
AB  - Advanced therapy medicinal products (ATMP) are associated with high expectations 
      because they offer new opportunities for the treatment of diseases, e.g., the
      possibility of regenerating damaged or lost tissue. What the products (gene
      therapy, somatic cell therapy, and tissue engineered products) have in common is 
      an innovative and complex development process that combines science and
      engineering. At the same time, this field of research is becoming increasingly
      interdisciplinary and requires international cooperation. A comprehensive
      assessment of ATMP has to take these issues into account. The application of
      Beauchamp and Childress' Four Principles (Principle-Based Ethics) as well as
      Discourse Ethics as a framework may lead to a broader consideration of medical
      ethics issues.
FAU - Thanner, M
AU  - Thanner M
AD  - Institut fur Medizinmanagement und Gesundheitswissenschaften, Universitat
      Bayreuth, 95440, Bayreuth, Deutschland. mirjam.thanner@uni-bayreuth.de
FAU - Nagel, E
AU  - Nagel E
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Arzneimittel fur neuartige Therapien umfassend bewerten. Problemfelder und
      Losungsansatze in der Ubersicht.
PL  - Germany
TA  - Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
JT  - Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
JID - 101181368
RN  - 0 (Biological Products)
SB  - IM
MH  - Biological Products/*therapeutic use
MH  - *Consumer Product Safety
MH  - Genetic Therapy/*ethics
MH  - Germany
MH  - Humans
MH  - International Cooperation
MH  - Principle-Based Ethics
MH  - Regenerative Medicine/*ethics
MH  - Stem Cell Transplantation/*ethics
MH  - Therapies, Investigational/*ethics
MH  - Tissue Engineering/*ethics
EDAT- 2011/06/24 06:00
MHDA- 2012/01/18 06:00
CRDT- 2011/06/24 06:00
PHST- 2011/06/24 06:00 [entrez]
PHST- 2011/06/24 06:00 [pubmed]
PHST- 2012/01/18 06:00 [medline]
AID - 10.1007/s00103-011-1300-7 [doi]
PST - ppublish
SO  - Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2011
      Jul;54(7):843-8. doi: 10.1007/s00103-011-1300-7.


PMID- 21698529
OWN - NLM
STAT- MEDLINE
DCOM- 20120117
LR  - 20160707
IS  - 1437-1588 (Electronic)
IS  - 1436-9990 (Linking)
VI  - 54
IP  - 7
DP  - 2011 Jul
TI  - [Advanced therapy medicinal products : Scientific, medical, economic, and ethical
      aspects].
PG  - 789-90
LID - 10.1007/s00103-011-1311-4 [doi]
FAU - Seitz, R
AU  - Seitz R
FAU - Schneider, C K
AU  - Schneider CK
FAU - Hengel, H
AU  - Hengel H
LA  - ger
PT  - Editorial
TT  - Arzneimittel fur neuartige Therapien. Wissenschaftliche, medizinische,
      okonomische und ethische Aspekte.
PL  - Germany
TA  - Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
JT  - Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
JID - 101181368
RN  - 0 (Biological Products)
SB  - IM
MH  - Biological Products/*therapeutic use
MH  - Ethics, Medical
MH  - Genetic Therapy/*economics/ethics/*legislation & jurisprudence
MH  - Germany
MH  - Humans
MH  - National Health Programs/*economics/ethics/*legislation & jurisprudence
MH  - Stem Cell Transplantation/economics/ethics/*legislation & jurisprudence
MH  - Therapies, Investigational/*economics/ethics
EDAT- 2011/06/24 06:00
MHDA- 2012/01/18 06:00
CRDT- 2011/06/24 06:00
PHST- 2011/06/24 06:00 [entrez]
PHST- 2011/06/24 06:00 [pubmed]
PHST- 2012/01/18 06:00 [medline]
AID - 10.1007/s00103-011-1311-4 [doi]
PST - ppublish
SO  - Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2011
      Jul;54(7):789-90. doi: 10.1007/s00103-011-1311-4.


PMID- 21698434
OWN - NLM
STAT- MEDLINE
DCOM- 20120213
LR  - 20211020
IS  - 1432-2129 (Electronic)
IS  - 0932-433X (Linking)
VI  - 25
IP  - 4
DP  - 2011 Aug
TI  - [Limits of pain treatment: medical and judicial aspects].
PG  - 377-80, 382-92
LID - 10.1007/s00482-011-1073-9 [doi]
AB  - Medical principles of pain treatment are generally in line with the judicial
      principles. To relieve pain is one of the fundamentals of medicine and this has
      also been acknowledged by the Federal Court in Germany. It is criminal bodily
      harm, when a physician denies a possible pain treatment. Whereas courts clearly
      see an obligation to basic and continuing education in pain diagnosis and
      therapy, pain is still not represented in the German licensing regulations for
      physicians. Only palliative medicine has been added to the obligatory curriculum.
      Very similar pain is not mandatory in many clinical disciplines leaving
      physicians without the needed knowledge to treat pain. The need for
      interdisciplinary treatment is not yet acknowledged sufficiently, although
      meanwhile chronic pain is regarded as a bio-psycho-social illness.Since 2009 the 
      advance directive is regulated by law. However, still many physicians are unaware
      that not only the position of the patient but also of the relatives have been
      strengthened. In 2010 the Federal Court has pronounced a judgment allowing
      "passive euthanasia" in certain conditions but prohibiting any active handling
      even in line with the patient's will. This is also in line with the European
      Human Rights Convention. The judicial unpunished assisted suicide has provoked an
      ethical discussion within the medical profession. However, what is not illegal is
      not automatically accepted as ethical handling for physicians. Palliative
      medicine is at least one alternative in this discussion.
FAU - Zenz, M
AU  - Zenz M
AD  - Ruhr-Universitat Bochum. zenz@anaesthesia.de
FAU - Rissing-van Saan, R
AU  - Rissing-van Saan R
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Grenzen der Schmerztherapie: Medizinische und Juristische Aspekte.
PL  - Germany
TA  - Schmerz
JT  - Schmerz (Berlin, Germany)
JID - 8906258
RN  - 0 (Narcotics)
SB  - IM
MH  - Advance Directives/ethics/legislation & jurisprudence
MH  - Cooperative Behavior
MH  - Dose-Response Relationship, Drug
MH  - Ethics, Medical
MH  - Euthanasia, Passive/ethics/legislation & jurisprudence
MH  - Expert Testimony/ethics/*legislation & jurisprudence
MH  - Germany
MH  - Humans
MH  - Informed Consent/ethics/legislation & jurisprudence
MH  - Interdisciplinary Communication
MH  - Malpractice/*legislation & jurisprudence
MH  - Medical Futility
MH  - Narcotics/administration & dosage/adverse effects
MH  - Neoplasms/physiopathology
MH  - Pain Management/*ethics
MH  - Pain, Postoperative/drug therapy
MH  - Palliative Care/ethics/legislation & jurisprudence
MH  - Patient Advocacy/ethics/*legislation & jurisprudence
MH  - Suicide, Assisted/ethics/legislation & jurisprudence
EDAT- 2011/06/24 06:00
MHDA- 2012/02/14 06:00
CRDT- 2011/06/24 06:00
PHST- 2011/06/24 06:00 [entrez]
PHST- 2011/06/24 06:00 [pubmed]
PHST- 2012/02/14 06:00 [medline]
AID - 10.1007/s00482-011-1073-9 [doi]
PST - ppublish
SO  - Schmerz. 2011 Aug;25(4):377-80, 382-92. doi: 10.1007/s00482-011-1073-9.


PMID- 21698223
OWN - NLM
STAT- MEDLINE
DCOM- 20111107
LR  - 20211020
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 6
IP  - 6
DP  - 2011
TI  - Signs of mood and anxiety disorders in chimpanzees.
PG  - e19855
LID - 10.1371/journal.pone.0019855 [doi]
AB  - BACKGROUND: In humans, traumatic experiences are sometimes followed by
      psychiatric disorders. In chimpanzees, studies have demonstrated an association
      between traumatic events and the emergence of behavioral disturbances resembling 
      posttraumatic stress disorder (PTSD) and depression. We addressed the following
      central question: Do chimpanzees develop posttraumatic symptoms, in the form of
      abnormal behaviors, which cluster into syndromes similar to those described in
      human mood and anxiety disorders? METHODOLOGY/PRINCIPAL FINDINGS: In phase 1 of
      this study, we accessed case reports of chimpanzees who had been reportedly
      subjected to traumatic events, such as maternal separation, social isolation,
      experimentation, or similar experiences. We applied and tested DSM-IV criteria
      for PTSD and major depression to published case reports of 20 chimpanzees
      identified through PrimateLit. Additionally, using the DSM-IV criteria and
      ethograms as guides, we developed behaviorally anchored alternative criteria that
      were applied to the case reports. A small number of chimpanzees in the case
      studies met DSM-IV criteria for PTSD and depression. Measures of inter-rater
      reliability, including Fleiss' kappa and percentage agreement, were higher with
      use of the alternative criteria for PTSD and depression. In phase 2, the
      alternative criteria were applied to chimpanzees living in wild sites in Africa
      (n = 196) and chimpanzees living in sanctuaries with prior histories of
      experimentation, orphanage, illegal seizure, or violent human conflict (n = 168).
      In phase 2, 58% of chimpanzees living in sanctuaries met the set of alternative
      criteria for depression, compared with 3% of chimpanzees in the wild (p = 0.04), 
      and 44% of chimpanzees in sanctuaries met the set of alternative criteria for
      PTSD, compared with 0.5% of chimpanzees in the wild (p = 0.04).
      CONCLUSIONS/SIGNIFICANCE: Chimpanzees display behavioral clusters similar to PTSD
      and depression in their key diagnostic criteria, underscoring the importance of
      ethical considerations regarding the use of chimpanzees in experimentation and
      other captive settings.
FAU - Ferdowsian, Hope R
AU  - Ferdowsian HR
AD  - Physicians Committee for Responsible Medicine, Washington, DC, United States of
      America. hferdowsian@pcrm.org
FAU - Durham, Debra L
AU  - Durham DL
FAU - Kimwele, Charles
AU  - Kimwele C
FAU - Kranendonk, Godelieve
AU  - Kranendonk G
FAU - Otali, Emily
AU  - Otali E
FAU - Akugizibwe, Timothy
AU  - Akugizibwe T
FAU - Mulcahy, J B
AU  - Mulcahy JB
FAU - Ajarova, Lilly
AU  - Ajarova L
FAU - Johnson, Cassie Mere
AU  - Johnson CM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110616
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
CIN - J Comp Psychol. 2013 Aug;127(3):329-36. PMID: 22889365
CIN - J Comp Psychol. 2013 Aug;127(3):337-40. PMID: 23978231
MH  - Animals
MH  - Anxiety/*physiopathology
MH  - Female
MH  - Male
MH  - Mood Disorders/*physiopathology
MH  - *Pan troglodytes
PMC - PMC3116818
EDAT- 2011/06/24 06:00
MHDA- 2011/11/08 06:00
CRDT- 2011/06/24 06:00
PHST- 2011/01/03 00:00 [received]
PHST- 2011/04/04 00:00 [accepted]
PHST- 2011/06/24 06:00 [entrez]
PHST- 2011/06/24 06:00 [pubmed]
PHST- 2011/11/08 06:00 [medline]
AID - 10.1371/journal.pone.0019855 [doi]
AID - PONE-D-11-00355 [pii]
PST - ppublish
SO  - PLoS One. 2011;6(6):e19855. doi: 10.1371/journal.pone.0019855. Epub 2011 Jun 16.


PMID- 21697968
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20220317
IS  - 2152-7806 (Electronic)
IS  - 2152-7806 (Linking)
VI  - 2
DP  - 2011
TI  - Virtual reality training in neurosurgery: Review of current status and future
      applications.
PG  - 52
LID - 10.4103/2152-7806.80117 [doi]
AB  - BACKGROUND: Over years, surgical training is changing and years of tradition are 
      being challenged by legal and ethical concerns for patient safety, work hour
      restrictions, and the cost of operating room time. Surgical simulation and skill 
      training offer an opportunity to teach and practice advanced techniques before
      attempting them on patients. Simulation training can be as straightforward as
      using real instruments and video equipment to manipulate simulated "tissue" in a 
      box trainer. More advanced virtual reality (VR) simulators are now available and 
      ready for widespread use. Early systems have demonstrated their effectiveness and
      discriminative ability. Newer systems enable the development of comprehensive
      curricula and full procedural simulations. METHODS: A PubMed review of the
      literature was performed for the MESH words "Virtual reality, "Augmented
      Reality", "Simulation", "Training", and "Neurosurgery". Relevant articles were
      retrieved and reviewed. A review of the literature was performed for the history,
      current status of VR simulation in neurosurgery. RESULTS: Surgical organizations 
      are calling for methods to ensure the maintenance of skills, advance surgical
      training, and credential surgeons as technically competent. The number of
      published literature discussing the application of VR simulation in neurosurgery 
      training has evolved over the last decade from data visualization, including
      stereoscopic evaluation to more complex augmented reality models. With the
      revolution of computational analysis abilities, fully immersive VR models are
      currently available in neurosurgery training. Ventriculostomy catheters
      insertion, endoscopic and endovascular simulations are used in neurosurgical
      residency training centers across the world. Recent studies have shown the
      coloration of proficiency with those simulators and levels of experience in the
      real world. CONCLUSION: Fully immersive technology is starting to be applied to
      the practice of neurosurgery. In the near future, detailed VR neurosurgical
      modules will evolve to be an essential part of the curriculum of the training of 
      neurosurgeons.
FAU - Alaraj, Ali
AU  - Alaraj A
AD  - Department of Neurosurgery, University of Illinois at Chicago College of
      Medicine, Chicago, USA.
FAU - Lemole, Michael G
AU  - Lemole MG
FAU - Finkle, Joshua H
AU  - Finkle JH
FAU - Yudkowsky, Rachel
AU  - Yudkowsky R
FAU - Wallace, Adam
AU  - Wallace A
FAU - Luciano, Cristian
AU  - Luciano C
FAU - Banerjee, P Pat
AU  - Banerjee PP
FAU - Rizzi, Silvio H
AU  - Rizzi SH
FAU - Charbel, Fady T
AU  - Charbel FT
LA  - eng
PT  - Journal Article
DEP - 20110428
PL  - United States
TA  - Surg Neurol Int
JT  - Surgical neurology international
JID - 101535836
PMC - PMC3114314
OTO - NOTNLM
OT  - Haptics
OT  - simulation
OT  - training
OT  - virtual reality
EDAT- 2011/06/24 06:00
MHDA- 2011/06/24 06:01
CRDT- 2011/06/24 06:00
PHST- 2011/01/08 00:00 [received]
PHST- 2011/03/18 00:00 [accepted]
PHST- 2011/06/24 06:00 [entrez]
PHST- 2011/06/24 06:00 [pubmed]
PHST- 2011/06/24 06:01 [medline]
AID - 10.4103/2152-7806.80117 [doi]
AID - SNI-2-52 [pii]
PST - ppublish
SO  - Surg Neurol Int. 2011;2:52. doi: 10.4103/2152-7806.80117. Epub 2011 Apr 28.


PMID- 21697918
OWN - NLM
STAT- MEDLINE
DCOM- 20110816
LR  - 20110623
IS  - 1476-4687 (Electronic)
IS  - 0028-0836 (Linking)
VI  - 474
IP  - 7352
DP  - 2011 Jun 22
TI  - Vaccine trial's ethics criticized.
PG  - 427-8
LID - 10.1038/474427a [doi]
FAU - Shetty, Priya
AU  - Shetty P
LA  - eng
PT  - News
DEP - 20110622
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (Papillomavirus Vaccines)
SB  - IM
CIN - Nature. 2011 Jul 21;475(7356):296. PMID: 21776067
MH  - Adolescent
MH  - Child
MH  - Clinical Trials as Topic/*ethics
MH  - Ethics, Research
MH  - Female
MH  - Guidelines as Topic
MH  - Humans
MH  - India
MH  - International Cooperation
MH  - Papillomavirus Infections/prevention & control
MH  - *Papillomavirus Vaccines/adverse effects
MH  - Registries
EDAT- 2011/06/24 06:00
MHDA- 2011/08/17 06:00
CRDT- 2011/06/24 06:00
PHST- 2011/06/24 06:00 [entrez]
PHST- 2011/06/24 06:00 [pubmed]
PHST- 2011/08/17 06:00 [medline]
AID - 474427a [pii]
AID - 10.1038/474427a [doi]
PST - epublish
SO  - Nature. 2011 Jun 22;474(7352):427-8. doi: 10.1038/474427a.


PMID- 21697296
OWN - NLM
STAT- MEDLINE
DCOM- 20120501
LR  - 20211020
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 2
DP  - 2012 Feb
TI  - Predictors of hospitalised patients' preferences for physician-directed medical
      decision-making.
PG  - 77-82
LID - 10.1136/jme.2010.040618 [doi]
AB  - BACKGROUND: Although medical ethicists and educators emphasise patient-centred
      decision-making, previous studies suggest that patients often prefer their
      doctors to make the clinical decisions. OBJECTIVE: To examine the associations
      between a preference for physician-directed decision-making and patient health
      status and sociodemographic characteristics. METHODS: Sociodemographic and
      clinical information from all consenting general internal medicine patients at
      the University of Chicago Medical Center were examined. The primary objectives
      were to (1) assess the extent to which patients prefer an active role in clinical
      decision-making, and (2) determine whether religious service attendance, the
      importance of religion, self-rated spirituality, Charlson Comorbidity Index,
      self-reported health, Vulnerable Elder Score and several demographic
      characteristics were associated with these preferences. RESULTS: Data were
      collected from 8308 of 11,620 possible participants. Ninety-seven per cent of
      respondents wanted doctors to offer them choices and to consider their opinions. 
      However, two out of three (67%) preferred to leave medical decisions to the
      doctor. In multiple regression analyses, preferring to leave decisions to the
      doctor was associated with older age (per year, OR=1.019, 95% CI 1.003 to 1.036) 
      and frequently attending religious services (OR=1.5, 95% CI 1.1 to 2.1, compared 
      with never), and it was inversely associated with female sex (OR=0.6, 95% CI 0.5 
      to 0.8), university education (OR=0.6, 95% CI 0.4 to 0.9, compared with no high
      school diploma) and poor health (OR=0.6, 95% CI 0.3 to 0.9). CONCLUSIONS: Almost 
      all patients want doctors to offer them choices and to consider their opinions,
      but most prefer to leave medical decisions to the doctor. Patients who are male, 
      less educated, more religious and healthier are more likely to want to leave
      decisions to their doctors, but effects are small.
FAU - Chung, Grace S
AU  - Chung GS
AD  - The University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA.
FAU - Lawrence, Ryan E
AU  - Lawrence RE
FAU - Curlin, Farr A
AU  - Curlin FA
FAU - Arora, Vineet
AU  - Arora V
FAU - Meltzer, David O
AU  - Meltzer DO
LA  - eng
GR  - K23 AT002749/AT/NCCIH NIH HHS/United States
GR  - K24 AG031326/AG/NIA NIH HHS/United States
GR  - 1K24 AG031326-01/AG/NIA NIH HHS/United States
GR  - 1K23 AT002749-01A1/AT/NCCIH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110622
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
CIN - J R Coll Physicians Edinb. 2013;43(2):136. PMID: 23734356
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Attitude to Health
MH  - Cross-Sectional Studies
MH  - Data Collection
MH  - *Decision Making
MH  - Educational Status
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Patient Participation/*psychology
MH  - Patient Preference/psychology/*statistics & numerical data
MH  - *Patient-Centered Care
MH  - Physician-Patient Relations
MH  - Religion
MH  - Spirituality
EDAT- 2011/06/24 06:00
MHDA- 2012/05/02 06:00
CRDT- 2011/06/24 06:00
PHST- 2011/06/24 06:00 [entrez]
PHST- 2011/06/24 06:00 [pubmed]
PHST- 2012/05/02 06:00 [medline]
AID - jme.2010.040618 [pii]
AID - 10.1136/jme.2010.040618 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Feb;38(2):77-82. doi: 10.1136/jme.2010.040618. Epub 2011 Jun
      22.


PMID- 21697295
OWN - NLM
STAT- MEDLINE
DCOM- 20120322
LR  - 20111216
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 1
DP  - 2012 Jan
TI  - Innovative surgery: the ethical challenges.
PG  - 9-12
LID - 10.1136/jme.2010.042150 [doi]
AB  - Innovative surgery raises four kinds of ethical challenges: potential harms to
      patients; compromised informed consent; unfair allocation of healthcare
      resources; and conflicts of interest. Lack of adequate data on innovations and
      lack of regulatory oversight contribute to these ethical challenges. In this
      paper these issues and the extent to which problems may be resolved by better
      evidence-gathering and more comprehensive regulation are explored. It is
      suggested that some ethical issues will be more resistant to resolution than
      others, owing to special features of both surgery and innovation.
FAU - Johnson, Jane
AU  - Johnson J
AD  - Department of Philosophy, Macquarie University, North Ryde, NSW 2109, Australia.
FAU - Rogers, Wendy
AU  - Rogers W
LA  - eng
PT  - Journal Article
DEP - 20110622
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Conflict of Interest
MH  - Ethics, Clinical
MH  - Harm Reduction
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Resource Allocation
MH  - Surgical Procedures, Operative/*ethics/legislation & jurisprudence
MH  - Therapies, Investigational/*ethics
EDAT- 2011/06/24 06:00
MHDA- 2012/03/23 06:00
CRDT- 2011/06/24 06:00
PHST- 2011/06/24 06:00 [entrez]
PHST- 2011/06/24 06:00 [pubmed]
PHST- 2012/03/23 06:00 [medline]
AID - jme.2010.042150 [pii]
AID - 10.1136/jme.2010.042150 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Jan;38(1):9-12. doi: 10.1136/jme.2010.042150. Epub 2011 Jun
      22.


PMID- 21697294
OWN - NLM
STAT- MEDLINE
DCOM- 20121031
LR  - 20120523
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 6
DP  - 2012 Jun
TI  - Is the commercialisation of human tissue and body material forbidden in the
      countries of the European Union?
PG  - 342-6
LID - 10.1136/jme.2010.038760 [doi]
AB  - The human body and its parts are widely perceived as matters beyond commercial
      usage. This belief is codified in several national and European documents. This
      so-called 'no-property rule' is held to be the default position across the
      countries of the European Union. However, a closer look at the most pertinent
      national and European documents, and also current practices in the field, reveals
      a gradual model of commercialisation of human tissue. In particular, we will
      argue that the ban on commercialisation of body material is not as strict as it
      may appear at first sight, leaving room for the commercial practice of tissue
      procurement and transfer. We argue for more transparent information for patients 
      and tissue donors, an intensified ethical debate on commercialisation practices, 
      and a critical review of current normative principles.
FAU - Lenk, Christian
AU  - Lenk C
AD  - Department for Medical Ethics and History of Medicine, University Medical Center 
      Gottingen, Humboldtallee 36, Gottingen 37073, Germany.
FAU - Beier, Katharina
AU  - Beier K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110622
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Commerce/ethics/*legislation & jurisprudence
MH  - European Union
MH  - Humans
MH  - Organ Transplantation/ethics/*legislation & jurisprudence
MH  - Tissue Banks/ethics/*legislation & jurisprudence
MH  - Tissue Donors/ethics/*legislation & jurisprudence
MH  - Tissue and Organ Procurement/ethics/*legislation & jurisprudence
EDAT- 2011/06/24 06:00
MHDA- 2012/11/01 06:00
CRDT- 2011/06/24 06:00
PHST- 2011/06/24 06:00 [entrez]
PHST- 2011/06/24 06:00 [pubmed]
PHST- 2012/11/01 06:00 [medline]
AID - jme.2010.038760 [pii]
AID - 10.1136/jme.2010.038760 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Jun;38(6):342-6. doi: 10.1136/jme.2010.038760. Epub 2011 Jun
      22.


PMID- 21696651
OWN - NLM
STAT- MEDLINE
DCOM- 20110914
LR  - 20211020
IS  - 1591-0199 (Print)
IS  - 1591-0199 (Linking)
VI  - 17
IP  - 2
DP  - 2011 Jun
TI  - Flow diversion in aneurysms trial: the design of the FIAT study.
PG  - 147-53
AB  - Intracranial aneurysms, particularly large and giant, fusiform or recurrent
      aneurysms are increasingly treated with flow diverters (FDs), a recently
      introduced and approved neurovascular device. While some rare cases may not be
      treated any other way, in most patients a more conventional, conservative, or
      validated approach such as coiling, parent vessel occlusion, or surgical clipping
      exists. Only a randomized clinical trial can answer the question of which
      treatment option leads to better patient outcomes.We report the design of the
      FIAT study, a clinical care trial aiming to compare angiographic and clinical
      outcomes following treatment with a Flow-Diverter or with the best conventional
      treatment option. The FIAT study will include both a randomized and a registry
      portion. Patients will be proposed randomization to either FD stenting or best
      conventional treatment option (observation, coiling, stenting, or clipping) as
      determined by the treating physician. FIAT will recruit a total of 338 patients, 
      to show that i) FD stenting can be performed with an 'acceptable' immediate
      complication rate of less than 15% morbidity and mortality (defined as mRS > 2); 
      ii) FD stenting can increase from 75 to 90% the proportion of patients with a
      "good outcome", defined as complete or near-complete occlusion of the aneurysm
      AND a good clinical outcome (mRS >/= 2) at one year, as compared to the best
      conventional option. The FIAT study provides a scientific and ethical context to 
      care for patients eligible for flow-diversion therapy.
FAU - Raymond, J
AU  - Raymond J
AD  - Centre Hospitalier de l'Universite de Montreal (CHUM), Notre-Dame Hospital,
      Department of Radiology and Interventional Neuroradiology Research Unit,
      Montreal, Quebec, Canada. jean.raymond@umontreal.ca
FAU - Darsaut, T E
AU  - Darsaut TE
FAU - Guilbert, F
AU  - Guilbert F
FAU - Weill, A
AU  - Weill A
FAU - Roy, D
AU  - Roy D
LA  - eng
PT  - Journal Article
DEP - 20110620
PL  - United States
TA  - Interv Neuroradiol
JT  - Interventional neuroradiology : journal of peritherapeutic neuroradiology,
      surgical procedures and related neurosciences
JID - 9602695
SB  - IM
MH  - Humans
MH  - Intracranial Aneurysm/*surgery
MH  - Neurosurgical Procedures/*instrumentation/*methods
MH  - *Prostheses and Implants
MH  - Randomized Controlled Trials as Topic/*methods
MH  - *Registries
PMC - PMC3287264
EDAT- 2011/06/24 06:00
MHDA- 2011/09/15 06:00
CRDT- 2011/06/24 06:00
PHST- 2010/11/02 00:00 [received]
PHST- 2011/01/08 00:00 [accepted]
PHST- 2011/06/24 06:00 [entrez]
PHST- 2011/06/24 06:00 [pubmed]
PHST- 2011/09/15 06:00 [medline]
AID - IN.v17.i2.p147 [pii]
AID - 10.1177/159101991101700202 [doi]
PST - ppublish
SO  - Interv Neuroradiol. 2011 Jun;17(2):147-53. doi: 10.1177/159101991101700202. Epub 
      2011 Jun 20.


PMID- 21696555
OWN - NLM
STAT- MEDLINE
DCOM- 20120103
LR  - 20220321
IS  - 1749-4486 (Electronic)
IS  - 1749-4478 (Linking)
VI  - 36
IP  - 4
DP  - 2011 Aug
TI  - A 20-year retrospective study of tonsil cancer incidence and survival trends in
      South East England: 1987-2006.
PG  - 325-35
LID - 10.1111/j.1749-4486.2011.02361.x [doi]
AB  - BACKGROUND: There has been an increasing incidence of tonsil cancer worldwide.
      Documenting these changes is crucial to cancer prevention and control measures,
      resource allocation and understanding disease aetiology. OBJECTIVE: To analyse
      the changing epidemiology of tonsil cancer in South East England over a 20-year
      period between 1987 and 2006. DESIGN: A retrospective, quantitative study using
      secondary anonymised data obtained from the Thames Cancer Registry, London. Data 
      were analysed using spss v.17 and survival analyses with Kaplan-Meier and Cox
      regression. SETTING: This study was conducted in South East of England comprising
      London, Kent, Surrey and Sussex counties with an average population of 12
      million. This population increased from 10.7 to 11.8 million (a 10% increase)
      between 1987 and 2006. PARTICIPANTS: All patients with tonsil cancer in South
      East England registered with the Thames Cancer Registry (ICD-10 code C09) between
      1987 and 2006. A total of 1794 patients' data were analysed. Ethical
      Considerations: Ethical approval was granted by the Kent Research Ethics
      Committee. MAIN OUTCOME MEASURES: Data were analysed for demographic trends
      including gender, age at diagnosis, yearly incidence and survival. RESULTS:
      Tonsil cancer incidence has increased significantly from 0.60 to 1.45 per 100,000
      in the 20 years (P < 0.001). This increase is mainly amongst men and age groups
      40-59 years with a significant reduction in age at diagnosis by 2 years from 61.6
      years in the first decade to 59.6 years in the second decade (P < 0.001).
      Survival was worse in men, older age groups and in the presence of synchronous
      tumours (P < 0.001). There has been a statistically significant increase in
      median survival times from tonsil cancer by about 3 years from 2.7 years in the
      first decade to 5.7 years in the second decade of this study (P < 0.001).
      CONCLUSIONS: Tonsil cancer incidence has increased in the 20 years of this study 
      in South East England, especially amongst men and age groups 40-59 years. There
      has also been significant reduction in the mean age at diagnosis and an increase 
      in median survival times for tonsil cancer. Further studies are needed to explain
      these trends.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Olaleye, O
AU  - Olaleye O
AD  - Department of Otolaryngology, Russells Hall Hospital, Dudley, West Midlands UK.
      dejolaleye@yahoo.com
FAU - Moorthy, R
AU  - Moorthy R
FAU - Lyne, O
AU  - Lyne O
FAU - Black, M
AU  - Black M
FAU - Mitchell, D
AU  - Mitchell D
FAU - Wiseberg, J
AU  - Wiseberg J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Clin Otolaryngol
JT  - Clinical otolaryngology : official journal of ENT-UK ; official journal of
      Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
JID - 101247023
SB  - IM
MH  - Adolescent
MH  - Age Distribution
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - England/epidemiology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - *Registries
MH  - Retrospective Studies
MH  - Sex Distribution
MH  - Survival Rate/trends
MH  - Time Factors
MH  - Tonsillar Neoplasms/diagnosis/*epidemiology
MH  - Young Adult
EDAT- 2011/06/24 06:00
MHDA- 2012/01/04 06:00
CRDT- 2011/06/24 06:00
PHST- 2011/06/24 06:00 [entrez]
PHST- 2011/06/24 06:00 [pubmed]
PHST- 2012/01/04 06:00 [medline]
AID - 10.1111/j.1749-4486.2011.02361.x [doi]
PST - ppublish
SO  - Clin Otolaryngol. 2011 Aug;36(4):325-35. doi: 10.1111/j.1749-4486.2011.02361.x.


PMID- 21696481
OWN - NLM
STAT- MEDLINE
DCOM- 20111216
LR  - 20110623
IS  - 1745-7599 (Electronic)
IS  - 1041-2972 (Linking)
VI  - 23
IP  - 7
DP  - 2011 Jul
TI  - Parental rights and decision making regarding vaccinations: ethical dilemmas for 
      the primary care provider.
PG  - 336-45
LID - 10.1111/j.1745-7599.2011.00627.x [doi]
AB  - PURPOSE: To discuss the ethical dilemma that a primary care nurse practitioner
      (NP) must face when parents refuse to have their children immunized. DATA
      SOURCES: Review of published literature on the topic. CONCLUSIONS: By listening
      carefully to their concerns, responding honestly, and providing clear information
      about the risks and benefits, NPs may be able to build trust and to convince once
      hesitant parents to have their children immunized. For those parents who refuse, 
      NPs may feel uncertain on how to respond. By considering the ethical principles
      to which they are bound, autonomy, beneficence, and non-maleficence, NPs can work
      with the parents to decide what treatment is best for the child. IMPLICATIONS FOR
      PRACTICE: Providing truthful information to parents and utilizing public
      awareness through recent discussions in the media and on the Internet may be able
      to obviate many of the concerns of parents, which may be getting in the way of
      universal immunization.
CI  - (c)2011 The Author(s) Journal compilation (c)2011 American Academy of Nurse
      Practitioners.
FAU - Fernbach, Alison
AU  - Fernbach A
AD  - Developmental Therapeutics Program, Columbia University Medical Center, New York,
      NY, USA. aef2120@columbia.edu
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110614
PL  - United States
TA  - J Am Acad Nurse Pract
JT  - Journal of the American Academy of Nurse Practitioners
JID - 8916634
MH  - Civil Rights/ethics/*legislation & jurisprudence/psychology
MH  - Communication
MH  - *Decision Making
MH  - *Ethics, Medical
MH  - Ethics, Nursing
MH  - Humans
MH  - Immunization Programs/ethics/*legislation & jurisprudence
MH  - Nurse Practitioners
MH  - Parent-Child Relations
MH  - *Parents
MH  - Patient Education as Topic/ethics/legislation & jurisprudence
MH  - Personal Autonomy
MH  - Primary Health Care/*ethics/legislation & jurisprudence
MH  - Professional-Family Relations/ethics
EDAT- 2011/06/24 06:00
MHDA- 2011/12/17 06:00
CRDT- 2011/06/24 06:00
PHST- 2011/06/24 06:00 [entrez]
PHST- 2011/06/24 06:00 [pubmed]
PHST- 2011/12/17 06:00 [medline]
AID - 10.1111/j.1745-7599.2011.00627.x [doi]
PST - ppublish
SO  - J Am Acad Nurse Pract. 2011 Jul;23(7):336-45. doi:
      10.1111/j.1745-7599.2011.00627.x. Epub 2011 Jun 14.


PMID- 21696373
OWN - NLM
STAT- MEDLINE
DCOM- 20110822
LR  - 20110623
IS  - 1751-0813 (Electronic)
IS  - 0005-0423 (Linking)
VI  - 89
IP  - 7
DP  - 2011 Jul
TI  - Lethal genetic disorder in Poll Merino/Merino sheep in Australia.
PG  - 254-9
LID - 10.1111/j.1751-0813.2011.00789.x [doi]
AB  - OBJECTIVES: Characterise a lethal genetic disorder in Poll Merino/Merino sheep
      DESIGN: Pathological description of a new congenital multisystem disorder in a
      commercial sheep flock, and analysis of breeding data collected each lambing
      season between 2004 and mid-lambing season 2010. PROCEDURE: Necropsies were
      conducted on six affected lambs and the mode of inheritance of the disorder was
      determined by pedigree and segregation analyses. RESULTS: The affected lambs were
      dwarfs with multiple defects in several organs, including skeleton, heart, liver 
      and kidneys. The disorder has been named brachygnathia, cardiomegaly and renal
      hypoplasia syndrome (BCRHS). Segregation analysis suggests the disorder is
      transmitted as an autosomal trait with a recessive mode of inheritance. An annual
      incidence of the disorder in the discovery flock of up to 2.5% was recorded.
      CONCLUSIONS: As a lethal disorder, the occurrence of BCRHS raises potential
      ethical and economic concerns for Merino breeders. The development of a DNA test 
      would be useful to investigate its distribution in the Australian wool-sheep
      population. As the disorder affects both the skeleton and several critical
      organs, including the heart, it may provide a potential animal model for
      investigating key developmental processes in humans and other animals.
CI  - (c) 2011 The Authors. Australian Veterinary Journal (c) 2011 Australian
      Veterinary Association.
FAU - Shariflou, M R
AU  - Shariflou MR
AD  - Faculty of Veterinary Science, University of Sydney, Sydney, Australia.
      mohammad.shariflou@sydney.edu.au
FAU - Wade, C M
AU  - Wade CM
FAU - Windsor, P A
AU  - Windsor PA
FAU - Tammen, I
AU  - Tammen I
FAU - James, J W
AU  - James JW
FAU - Nicholas, F W
AU  - Nicholas FW
LA  - eng
PT  - Journal Article
PL  - England
TA  - Aust Vet J
JT  - Australian veterinary journal
JID - 0370616
SB  - IM
MH  - Abnormalities, Multiple/genetics/pathology/*veterinary
MH  - Animals
MH  - Animals, Newborn/abnormalities/genetics
MH  - Australia
MH  - *Breeding
MH  - Female
MH  - Genetic Variation
MH  - *Genetics, Population
MH  - Male
MH  - Pedigree
MH  - Sheep
MH  - Sheep Diseases/*genetics/*pathology
EDAT- 2011/06/24 06:00
MHDA- 2011/08/23 06:00
CRDT- 2011/06/24 06:00
PHST- 2011/06/24 06:00 [entrez]
PHST- 2011/06/24 06:00 [pubmed]
PHST- 2011/08/23 06:00 [medline]
AID - 10.1111/j.1751-0813.2011.00789.x [doi]
PST - ppublish
SO  - Aust Vet J. 2011 Jul;89(7):254-9. doi: 10.1111/j.1751-0813.2011.00789.x.


PMID- 21696283
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20110623
IS  - 1466-187X (Electronic)
IS  - 0142-159X (Linking)
VI  - 33
IP  - 7
DP  - 2011
TI  - Training healthcare professionals for the future: internationalism and effective 
      inclusion of global health training.
PG  - 562-9
LID - 10.3109/0142159X.2011.578470 [doi]
AB  - There has been a continuing rise in recent years of the number of medical schools
      in the developed world offering 'global health' teaching to its students. Yet,
      the term itself is used in a number of contexts and as yet no clear consensus on 
      what constitutes an appropriate or successful global health education programme
      has been reached. Approaches to sustainable internationalisation of medical
      curricula include the expansion of not only opportunities for training in
      specific global health topics, but also the development of broader generic
      graduate attributes including global citizenship and ethical, cultural and social
      responsibility. Key components for successful implementation of such an
      educational framework includes a breadth of educational approach to effect truly 
      integrated and effective curricular internationalisation. That such programmes
      can offer benefits is appreciated by both faculty and students alike, but there
      is also a burgeoning concern about potential negative effects of socially and
      culturally insensitive programmes. We explore three potential pedagogic
      approaches to the subject; Model A: an 'additive' or contributory model of global
      health content (the commonest current approach), Model B: an 'integrated'
      approach and Model C: the more challenging 'transformative' approach requiring
      institutional as well as programme flexibility.
FAU - Eaton, Deborah Murdoch
AU  - Eaton DM
AD  - University of Leeds, UK. d.g.murdoch-eaton@leeds.ac.uk
FAU - Redmond, Anthony
AU  - Redmond A
FAU - Bax, Nigel
AU  - Bax N
LA  - eng
PT  - Journal Article
PL  - England
TA  - Med Teach
JT  - Medical teacher
JID - 7909593
SB  - IM
MH  - *Curriculum
MH  - Health Personnel/*education
MH  - Humans
MH  - *Internationality
MH  - Models, Organizational
EDAT- 2011/06/24 06:00
MHDA- 2011/11/09 06:00
CRDT- 2011/06/24 06:00
PHST- 2011/06/24 06:00 [entrez]
PHST- 2011/06/24 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - 10.3109/0142159X.2011.578470 [doi]
PST - ppublish
SO  - Med Teach. 2011;33(7):562-9. doi: 10.3109/0142159X.2011.578470.


PMID- 21696095
OWN - NLM
STAT- MEDLINE
DCOM- 20110713
LR  - 20191112
IS  - 1054-6863 (Print)
IS  - 1054-6863 (Linking)
VI  - 21
IP  - 2
DP  - 2011 Jun
TI  - Speaking of the value of life.
PG  - 181-99
AB  - The phrase 'the value of life' is important in bioethics, particularly for those 
      who hold the traditional views that life has intrinsic value and that the
      distinction between killing and allowing to die is valid. Ambiguities in the
      meaning of 'the value of life,' however, can lead to errors in medical ethical
      analysis by those who hold these traditional views. This essay notes three
      sources of such ambiguity: (1) three senses of the verb 'is,' (2) the difference 
      between the transcendent and the transcendental, and (3) the difference between
      the transcendental and the empirical. On the basis of these distinctions, several
      conclusions are drawn: that the value of life is transcendental, not
      transcendent, both finite and priceless, that decisions to withhold or withdraw
      life-sustaining treatments are always judgments about the qualities of a person's
      life, so one cannot universally condemn "quality of life judgments," that the
      traditional distinction between killing and allowing to die tracks the
      distinction between the transcendental and the empirical, that "life itself" is
      not a benefit of treatment, and that foregoing treatments that are not futile can
      be consistent with respect for the value of life.
FAU - Sulmasy, Daniel P
AU  - Sulmasy DP
AD  - Department of Medicine and Divinity School, University of Chicago, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Kennedy Inst Ethics J
JT  - Kennedy Institute of Ethics journal
JID - 9109135
SB  - IM
MH  - Decision Making/ethics
MH  - Humans
MH  - Medical Futility/ethics
MH  - *Philosophy, Medical
MH  - *Quality of Life
MH  - *Value of Life
MH  - Withholding Treatment/ethics
EDAT- 2011/06/24 06:00
MHDA- 2011/07/14 06:00
CRDT- 2011/06/24 06:00
PHST- 2011/06/24 06:00 [entrez]
PHST- 2011/06/24 06:00 [pubmed]
PHST- 2011/07/14 06:00 [medline]
AID - 10.1353/ken.2011.0006 [doi]
PST - ppublish
SO  - Kennedy Inst Ethics J. 2011 Jun;21(2):181-99. doi: 10.1353/ken.2011.0006.


PMID- 21696093
OWN - NLM
STAT- MEDLINE
DCOM- 20110713
LR  - 20191112
IS  - 1054-6863 (Print)
IS  - 1054-6863 (Linking)
VI  - 21
IP  - 2
DP  - 2011 Jun
TI  - How clinical trials really work rethinking research ethics.
PG  - 121-39
AB  - Despite prevalent concerns about the ethical conduct of clinical trials, little
      is known about the day-to-day work of trials and the ethical challenges arising
      in them. This paper reports on a study designed to fill this gap and demonstrates
      a need to refine the oversight system for trials to reflect an understanding of
      this day-to-day work. It also illuminates ethical challenges that cannot be
      addressed by the oversight system and so necessitate a rethinking of the ethics
      of clinical trials.
FAU - DeBruin, Debra A
AU  - DeBruin DA
AD  - Center for Bioethics, University of Minnesota, USA.
FAU - Liaschenko, Joan
AU  - Liaschenko J
FAU - Fisher, Anastasia
AU  - Fisher A
LA  - eng
GR  - R01-NR08420-01/NR/NINR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Kennedy Inst Ethics J
JT  - Kennedy Institute of Ethics journal
JID - 9109135
SB  - IM
MH  - Adult
MH  - Aged
MH  - Clinical Trials as Topic/*ethics
MH  - Ethical Review
MH  - Ethics Committees, Research
MH  - Ethics, Nursing
MH  - Ethics, Research
MH  - Female
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Male
MH  - Middle Aged
MH  - Narration
MH  - Nurse-Patient Relations/*ethics
MH  - *Nurses
MH  - Patient Selection/*ethics
MH  - Research Design
MH  - Research Personnel/*ethics
MH  - Researcher-Subject Relations/*ethics
MH  - United States
MH  - *Workflow
MH  - Workload
EDAT- 2011/06/24 06:00
MHDA- 2011/07/14 06:00
CRDT- 2011/06/24 06:00
PHST- 2011/06/24 06:00 [entrez]
PHST- 2011/06/24 06:00 [pubmed]
PHST- 2011/07/14 06:00 [medline]
AID - 10.1353/ken.2011.0008 [doi]
PST - ppublish
SO  - Kennedy Inst Ethics J. 2011 Jun;21(2):121-39. doi: 10.1353/ken.2011.0008.


PMID- 21696009
OWN - NLM
STAT- MEDLINE
DCOM- 20111206
LR  - 20110622
IS  - 0036-7281 (Print)
IS  - 0036-7281 (Linking)
VI  - 153
IP  - 5
DP  - 2011 May
TI  - [Killing and dignity of animals: a problem for veterinarians?].
PG  - 209-14
AB  - Killing of animals is an important task to be performed by veterinarians. Killing
      decisions and their implementation often raise ethical questions. As a result of 
      an interdisciplinary workshop targeting the subject "killing of animals" with
      veterinarians and ethicists, a three-dimensional dimension scheme was developed. 
      Whereas the first two dimensions are focused on the animal's past and future life
      and are discussed with regard to life quality and life accomplishment (the
      "telos"), the third dimension incorporates the reason to kill and may integrate
      the concept of dignity. This form of dignity and the weighing of interests are
      applied to example scenarios and the resulting responsibilities of veterinarians 
      and society are discussed.
FAU - Fahrion
AU  - Fahrion
AD  - Veterinary Public Health Institut, Universitat Bern.
FAU - Durr, S
AU  - Durr S
FAU - Doherr, M G
AU  - Doherr MG
FAU - Hartnack, S
AU  - Hartnack S
FAU - Kunzmann, P
AU  - Kunzmann P
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
TT  - Das Toten und die Wurde von Tieren: ein Problem fur Tierarzte?
PL  - Switzerland
TA  - Schweiz Arch Tierheilkd
JT  - Schweizer Archiv fur Tierheilkunde
JID - 0424247
SB  - IM
MH  - Animals
MH  - Euthanasia, Animal/*ethics
MH  - Quality of Life
MH  - Right to Die
MH  - Veterinarians/*ethics
EDAT- 2011/06/24 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/06/24 06:00
PHST- 2011/06/24 06:00 [entrez]
PHST- 2011/06/24 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1024/0036-7281/a000184 [doi]
PST - ppublish
SO  - Schweiz Arch Tierheilkd. 2011 May;153(5):209-14. doi: 10.1024/0036-7281/a000184.


PMID- 21695941
OWN - NLM
STAT- MEDLINE
DCOM- 20110818
LR  - 20110622
IS  - 0324-0959 (Print)
IS  - 0324-0959 (Linking)
VI  - 50
IP  - 1
DP  - 2011
TI  - [The very low birth weight and very low gestational age neonates--survival,
      prognosis and perspectives].
PG  - 31-6
AB  - The advances in perinatal medicine during the last decades lead to a reduction in
      neonatal mortality rates in risk newborns and a gradual lowering of the
      gestational age when survival is possible to 22 weeks of gestation. In the
      present survey we are making a review of the studies about the survival and the
      prognosis in neonates with very low birth weight and gestational age (VLBW,
      VLGA). Infants weighting more than 1000 g and with gestational age above 28 g.w. 
      are with a good prognosis: low neonatal mortality and morbidity rates. In
      newborns with gestational age between 26 and 28 g.w. the neonatal mortality rates
      are relatively low, however the trend of further lowering has not changed during 
      the last 15 years; morbidity rates varies between different centers and are
      relatively high. The greatest medical, social and ethical dilemmas represent the 
      newborns with gestational age less than 25 g.w. In this group with an overall
      high neonatal mortality (with big variations between different centers), there is
      a significant high morbidity rate among survived babies. These are the infants at
      the border of perinatal viability, the "grey zone" of the neonatology, where
      further discussions are going on about the activity of the obstetric management, 
      the intensity and the amount of neonatal resuscitation.
FAU - Vakrilova, L
AU  - Vakrilova L
FAU - Stancheva, B
AU  - Stancheva B
FAU - Dimitrov, A
AU  - Dimitrov A
FAU - Nikolov, A
AU  - Nikolov A
LA  - bul
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Bulgaria
TA  - Akush Ginekol (Sofiia)
JT  - Akusherstvo i ginekologiia
JID - 0370455
SB  - IM
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Very Low Birth Weight/*physiology
MH  - Neonatology/*trends
MH  - Prognosis
MH  - Survival
EDAT- 2011/06/24 06:00
MHDA- 2011/08/19 06:00
CRDT- 2011/06/24 06:00
PHST- 2011/06/24 06:00 [entrez]
PHST- 2011/06/24 06:00 [pubmed]
PHST- 2011/08/19 06:00 [medline]
PST - ppublish
SO  - Akush Ginekol (Sofiia). 2011;50(1):31-6.


PMID- 21695410
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1534-3189 (Electronic)
IS  - 1092-8464 (Linking)
VI  - 13
IP  - 5
DP  - 2011 Oct
TI  - Ethical Dilemmas and End-of-Life Choices for Patients with Implantable Cardiac
      Devices: Decisions Regarding Discontinuation of Therapy.
PG  - 385-92
LID - 10.1007/s11936-011-0136-7 [doi]
AB  - OPINION STATEMENT: It is our belief that a well-designed cardiac device
      management program should include end-of-life patient and family planning,
      addressing potential decisions regarding withdrawal of pacemaker and/or
      implantable cardioverter defibrillator therapy. Guided by the basic ethical and
      legal principles outlined in the article, it is the responsibility of the
      electrophysiologist and other involved health care providers to introduce this
      topic to patients, provide guidance and resources for decision making, and honor 
      both patient and family requests.
FAU - Grubb, Blair P
AU  - Grubb BP
AD  - Cardiology, University of Toledo Medical Center, 3000 Arlington Avenue, Mail Stop
      1118, Toledo, OH, 43614, USA, Blair.Grubb@utoledo.edu.
FAU - Karabin, Beverly
AU  - Karabin B
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Curr Treat Options Cardiovasc Med
JT  - Current treatment options in cardiovascular medicine
JID - 9815942
EDAT- 2011/06/23 06:00
MHDA- 2011/06/23 06:01
CRDT- 2011/06/23 06:00
PHST- 2011/06/23 06:00 [entrez]
PHST- 2011/06/23 06:00 [pubmed]
PHST- 2011/06/23 06:01 [medline]
AID - 10.1007/s11936-011-0136-7 [doi]
PST - ppublish
SO  - Curr Treat Options Cardiovasc Med. 2011 Oct;13(5):385-92. doi:
      10.1007/s11936-011-0136-7.


PMID- 21695371
OWN - NLM
STAT- MEDLINE
DCOM- 20111101
LR  - 20220318
IS  - 1945-404X (Electronic)
IS  - 0090-7421 (Linking)
VI  - 40
IP  - 2
DP  - 2011 Summer
TI  - A conceptual framework for international service-learning course planning:
      promoting a foundation for ethical practice in the physical therapy and
      occupational therapy professions.
PG  - 103-9
AB  - As physical therapy (PT) and occupational therapy (OT) educational programs
      endeavor to foster core values of social responsibility, justice, and altruism in
      an increasingly global community, the incorporation of local and international
      service-learning (ISL) into the curriculum is growing. Much of the research has
      focused on the measurement of student learning, with little written about the
      impact on the host community. Proponents of global health initiatives are calling
      for consideration of all stakeholders to ensure ethical practice. This paper
      explores the current literature related to PT and OT ISL and builds a conceptual 
      framework for ISL course planning. The essential phases in the framework include:
      1) pre-experience planning/preparation stage, 2) field immersion experience
      stage, and 3) postexperience stage. The essential elements are: 1) cultural
      competency training, 2) communication and coordination with community, 3)
      comprehensive assessment, and 4) strategic planning. The authors suggest this
      framework as a practical tool to structure ISL courses with an explicit emphasis 
      on ethical concerns. Additionally, they seek to foster more dialogue and action
      related to the promotion of ethical practices in ISL in PT and OT education
      programs.
FAU - Lattanzi, Jill Black
AU  - Lattanzi JB
AD  - Physical Therapy Program, University of Texas at El Paso, 1101 North Campbell, El
      Paso, TX 79902, USA.
FAU - Pechak, Celia
AU  - Pechak C
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Allied Health
JT  - Journal of allied health
JID - 0361603
SB  - IM
MH  - Community-Institutional Relations
MH  - Cultural Competency/education
MH  - Curriculum
MH  - Ethics, Professional/*education
MH  - Humans
MH  - *International Cooperation
MH  - Occupational Therapy/*education/ethics
MH  - Physical Therapy Specialty/*education/ethics
MH  - Program Development
MH  - *Social Welfare
MH  - United States
EDAT- 2011/06/23 06:00
MHDA- 2011/11/02 06:00
CRDT- 2011/06/23 06:00
PHST- 2009/11/16 00:00 [received]
PHST- 2010/10/13 00:00 [accepted]
PHST- 2011/06/23 06:00 [entrez]
PHST- 2011/06/23 06:00 [pubmed]
PHST- 2011/11/02 06:00 [medline]
PST - ppublish
SO  - J Allied Health. 2011 Summer;40(2):103-9.


PMID- 21694965
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1998-4014 (Electronic)
IS  - 1998-4014 (Linking)
VI  - 9
IP  - 1
DP  - 2011 Jan
TI  - The neuroendocrine system and stress, emotions, thoughts and feelings.
PG  - 113-28
LID - 10.4103/0973-1229.77430 [doi]
AB  - The philosophy of mind is intimately connected with the philosophy of action.
      Therefore, concepts like free will, motivation, emotions (especially positive
      emotions), and also the ethical issues related to these concepts are of abiding
      interest. However, the concepts of consciousness and free will are usually
      discussed solely in linguistic, ideational and cognitive (i.e. "left brain")
      terms. Admittedly, consciousness requires language and the left-brain, but the
      aphasic right brain is equally conscious; however, what it "hears" are more
      likely to be music and emotions. Joy can be as conscious as the conscious
      motivation produced by the left-brain reading a sign that says, "Danger mines!!" 
      However, look in the index of a Western textbook of psychology, psychiatry or
      philosophy for positive emotions located in the limbic system. Notice how
      discussion of positive spiritual/emotional issues in consciousness and motivation
      are scrupulously ignored. For example, the popular notions of "love" being either
      Eros (raw, amoral instinct) or agape (noble, non-specific valuing of all other
      people) miss the motivational forest for the trees. Neither Eros (hypothalamic)
      nor agape (cortical) has a fraction of the power to relieve stress as attachment 
      (limbic love), yet until the 1950s attachment was neither appreciated nor
      discussed by academic minds. This paper will point out that the prosocial,
      "spiritual" positive emotions like hope, faith, forgiveness, joy, compassion and 
      gratitude are extremely important in the relief of stress and in regulation of
      the neuroendocrine system, protecting us against stress. The experimental work
      reviewed by Antonio Damasio and Barbara Fredrickson, and the clinical example of 
      Alcoholics Anonymous, will be used to illustrate these points.
FAU - Vaillant, George E
AU  - Vaillant GE
AD  - Harvard Medical School, 1249 Boylston St, Boston, MA 02215, USA.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Mens Sana Monogr
JT  - Mens sana monographs
JID - 101506580
PMC - PMC3115283
OTO - NOTNLM
OT  - Limbic system
OT  - Positive emotions
OT  - Spiritual
OT  - "Right-brain"
EDAT- 2011/06/23 06:00
MHDA- 2011/06/23 06:01
CRDT- 2011/06/23 06:00
PHST- 2009/12/14 00:00 [received]
PHST- 2010/12/16 00:00 [revised]
PHST- 2010/12/17 00:00 [accepted]
PHST- 2011/06/23 06:00 [entrez]
PHST- 2011/06/23 06:00 [pubmed]
PHST- 2011/06/23 06:01 [medline]
AID - 10.4103/0973-1229.77430 [doi]
AID - MSM-9-113 [pii]
PST - ppublish
SO  - Mens Sana Monogr. 2011 Jan;9(1):113-28. doi: 10.4103/0973-1229.77430.


PMID- 21693662
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20220331
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 260
IP  - 2
DP  - 2011 Aug
TI  - Detection of pancreatic carcinoma and liver metastases with gadoxetic
      acid-enhanced MR imaging: comparison with contrast-enhanced multi-detector row
      CT.
PG  - 446-53
LID - 10.1148/radiol.11103548 [doi]
AB  - PURPOSE: To intraindividually compare gadoxetic acid-enhanced magnetic resonance 
      (MR) imaging with contrast material-enhanced multi-detector row computed
      tomography (CT) in detection of pancreatic carcinoma and liver metastases.
      MATERIALS AND METHODS: The ethics committee approved this retrospective study
      with waiver of informed consent. This study included 100 patients (53 men, 47
      women; mean age, 67.8 years) consisting of 54 patients with pathologically
      confirmed pancreatic carcinoma (mean size, 33 mm) and 46 without a pancreatic
      lesion. Sixty-two liver metastases (mean size, 10 mm) in 15 patients with
      pancreatic carcinoma were diagnosed at pathologic examination or multimodality
      assessment. Three readers blinded to the final diagnosis interpreted all MR
      (precontrast T1- and T2-weighted and gadoxetic acid-enhanced dynamic and
      hepatocyte phase MR images) and tetraphasic dynamic contrast-enhanced CT images
      and graded the presence (or absence) of pancreatic carcinoma and liver metastasis
      on patient-by-patient and lesion-by-lesion bases. Receiver operating
      characteristic analysis, McNemar test, and Fisher test were performed to compare 
      the diagnostic performance of CT and MR imaging. RESULTS: No significant
      differences were observed between CT and MR images in depiction of pancreatic
      carcinoma. However, MR imaging had greater sensitivity in depicting liver
      metastasis than did CT for two of the three readers in the MR imaging-versus-CT
      analysis (85% vs 69%, P = .046) and for all three readers in the lesion-by-lesion
      analysis (92%-94% vs 74%-76%, P = .030-.044). CONCLUSION: Gadoxetic acid-enhanced
      MR imaging was equivalent to dynamic contrast-enhanced CT in depicting pancreatic
      carcinoma and had better sensitivity for depicting liver metastases, suggesting
      the usefulness of gadoxetic acid-enhanced MR imaging for evaluation of patients
      with pancreatic carcinoma.
CI  - (c) RSNA, 2011.
FAU - Motosugi, Utaroh
AU  - Motosugi U
AD  - Department of Radiology, University of Yamanashi, 1110 Shimokato, Chuo-shi,
      Yamanashi 409-3898, Japan.
FAU - Ichikawa, Tomoaki
AU  - Ichikawa T
FAU - Morisaka, Hiroyuki
AU  - Morisaka H
FAU - Sou, Hironobu
AU  - Sou H
FAU - Muhi, Ali
AU  - Muhi A
FAU - Kimura, Kazufumi
AU  - Kimura K
FAU - Sano, Katsuhiro
AU  - Sano K
FAU - Araki, Tsutomu
AU  - Araki T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110621
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - 0 (gadolinium ethoxybenzyl DTPA)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adenocarcinoma/diagnostic imaging/*secondary
MH  - Aged
MH  - *Contrast Media
MH  - Female
MH  - *Gadolinium DTPA
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Liver Neoplasms/diagnostic imaging/*secondary
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Pancreatic Neoplasms/diagnostic imaging/*pathology
MH  - ROC Curve
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - Statistics, Nonparametric
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2011/06/23 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/06/23 06:00
PHST- 2011/06/23 06:00 [entrez]
PHST- 2011/06/23 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - radiol.11103548 [pii]
AID - 10.1148/radiol.11103548 [doi]
PST - ppublish
SO  - Radiology. 2011 Aug;260(2):446-53. doi: 10.1148/radiol.11103548. Epub 2011 Jun
      21.


PMID- 21693567
OWN - NLM
STAT- MEDLINE
DCOM- 20120322
LR  - 20150813
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 1
DP  - 2012 Jan
TI  - Research and complicity: the case of Julius Hallervorden.
PG  - 53-6
LID - 10.1136/jme.2011.044586 [doi]
AB  - The charge of complicity has been raised in debates over the ethics of fetal
      tissue transplantation and embryonic stem cell research. However, the
      applicability of the concept of complicity to these types of research is neither 
      clear nor uncontroversial. This article discusses the historical case of Julius
      Hallervorden, a distinguished German neuropathologist who conducted research on
      brains of mentally handicapped patients killed in the context of the Nazi
      'euthanasia' programme. It is argued that this case constitutes a paradigm of
      complicity in research that is useful in assessing complicity in contemporary
      research ethics.
FAU - Miller, Franklin G
AU  - Miller FG
AD  - Department of Bioethics, National Institutes of Health, Bethesda, MD 20892-1156, 
      USA. fmiller@nih.gov
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
DEP - 20110621
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Complicity
MH  - Ethics, Research
MH  - Euthanasia/ethics/*history
MH  - Fetal Tissue Transplantation/*ethics
MH  - Germany
MH  - History, 19th Century
MH  - History, 20th Century
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - National Socialism
MH  - Physicians/ethics
MH  - Political Systems
MH  - Research
MH  - Stem Cell Research/*ethics
MH  - War Crimes/*history
EDAT- 2011/06/23 06:00
MHDA- 2012/03/23 06:00
CRDT- 2011/06/23 06:00
PHST- 2011/06/23 06:00 [entrez]
PHST- 2011/06/23 06:00 [pubmed]
PHST- 2012/03/23 06:00 [medline]
AID - jme.2011.044586 [pii]
AID - 10.1136/jme.2011.044586 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Jan;38(1):53-6. doi: 10.1136/jme.2011.044586. Epub 2011 Jun
      21.


PMID- 21693566
OWN - NLM
STAT- MEDLINE
DCOM- 20120322
LR  - 20111216
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 1
DP  - 2012 Jan
TI  - The Israeli abortion committees' process of decision making: an ethical analysis.
PG  - 26-30
LID - 10.1136/jme.2009.032797 [doi]
AB  - The Israeli law of abortions (1977) legally authorises hospital committees to
      decide upon women's requests for selective abortion. One of the law's clauses
      determines that abortions can be approved in cases of an embryopathy. However,
      the law does not provide any clear definitions of those fetal 'physical or mental
      defects' in terms of severity and/or likelihood, which remain open to
      interpretation by the committee members. This paper aimed to determine which
      ethical methodologies are used by committee members and advisors as they face the
      dilemma of abortion approval due to mild to moderate possible embryopathy. Twenty
      interviews demonstrated that they use mainly a combination of deontology and a
      contextual-relational model. Their ethical considerations are both contextual
      such as the family's/woman's relational network and are influenced by the ethical
      principles of autonomy and in cases of late abortions the value of life. The
      findings reveal a paradoxical picture: on the one hand, committee members hold
      liberal perceptions and in practice abortion requests are very seldom rejected.
      On the other hand, the Israeli abortion law and practice of abortion committees
      is still problematical from liberal and feminist rights perspectives. This
      paradox is discussed further by reflecting upon the relevant theory as well as
      the Israeli context. The paper concludes by suggesting that within the specific
      Israeli sociopolitical climate the requirement for committee approval of what
      should be a private decision might be necessary in order to placate religious or 
      other opposition to abortion.
FAU - Rimon-Zarfaty, Nitzan
AU  - Rimon-Zarfaty N
AD  - Department of Sociology and Anthropology, Ben-Gurion University of the Negev,
      Beer-Sheva, Israel. rimonn@bgu.ac.il
FAU - Jotkowitz, Alan
AU  - Jotkowitz A
LA  - eng
PT  - Journal Article
DEP - 20110621
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Abortion, Induced
MH  - Abortion, Legal/*legislation & jurisprudence
MH  - Decision Making/*ethics
MH  - Ethical Analysis
MH  - Ethical Theory
MH  - Ethics, Medical
MH  - Female
MH  - Human Rights
MH  - Humans
MH  - Israel
MH  - Jurisprudence
MH  - Politics
MH  - Pregnancy
EDAT- 2011/06/23 06:00
MHDA- 2012/03/23 06:00
CRDT- 2011/06/23 06:00
PHST- 2011/06/23 06:00 [entrez]
PHST- 2011/06/23 06:00 [pubmed]
PHST- 2012/03/23 06:00 [medline]
AID - jme.2009.032797 [pii]
AID - 10.1136/jme.2009.032797 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Jan;38(1):26-30. doi: 10.1136/jme.2009.032797. Epub 2011 Jun
      21.


PMID- 21693271
OWN - NLM
STAT- MEDLINE
DCOM- 20111014
LR  - 20141120
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 43
IP  - 5
DP  - 2011 Jun
TI  - Suitable calcineurin inhibitor concentrations for liver transplant recipients in 
      the Chinese population.
PG  - 1751-3
LID - 10.1016/j.transproceed.2010.11.025 [doi]
AB  - AIM: The aim was to deduce suitable calcineurin inhibitor concentrations for the 
      Chinese liver transplantation population. METHODS: We retrospectively studied 97 
      liver transplant recipients who displayed stable liver and renal function. No
      grafts were obtained from prisoners, procurements were performed with donor
      consent conforming to international ethics regulations. At 3, 6, and 12 months,
      we increased the concentrations and doses of calcineurin inhibitors as well as
      the values of alanine transaminase and serum creatinine. RESULTS: Twenty-eight
      recipients received cyclosporine and 69 tacrolimus. The mean cyclosporine daily
      dosages were 203 +/- 62 mg at 3, 188 +/- 55 mg at 6, and 173 +/- 52 mg at 12
      months, the tacrolimus daily dosages were 3.08 +/- 0.98, 2.82 +/- 0.98, and 2.58 
      +/- 0.93 mg, respectively. The corresponding mean cyclosporine peak
      concentrations (C(2)) were 806 +/- 322 ng/mL, 681 +/- 206 ng/mL, and 644 +/- 190 
      ng/mL and the mean tacrolimus trought concentrations (C(0)) 6.61 +/- 3.02 ng/mL, 
      5.85 +/- 2.44 ng/mL, and 5.22 +/- 2.33 ng/mL, respectively. In both groups,
      transaminases and serum creatinine were stable over time. CONCLUSIONS: An
      individualized immunosuppressive regimen for the local population is necessary.
      We delayed calcineurin inhibitors with subsequent low-dose mycophenolate mofetil 
      plus minimized calcineurin inhibitors, which seemed to be nephroprotective and
      safe for Chinese liver transplantation patients.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Chen, Y B
AU  - Chen YB
AD  - Department of Hepatobilliary Surgery, Beijing Military Region General Hospital,
      Beijing, China.
FAU - Li, S D
AU  - Li SD
FAU - Ju, B L
AU  - Ju BL
FAU - Shi, X J
AU  - Shi XJ
FAU - Lu, F
AU  - Lu F
FAU - Hu, D K
AU  - Hu DK
FAU - Yu, C H
AU  - Yu CH
FAU - Dong, J H
AU  - Dong JH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - 0 (Calcineurin Inhibitors)
RN  - 0 (Immunosuppressive Agents)
RN  - 83HN0GTJ6D (Cyclosporine)
RN  - WM0HAQ4WNM (Tacrolimus)
SB  - IM
MH  - Adult
MH  - *Calcineurin Inhibitors
MH  - China
MH  - Cyclosporine/*administration & dosage/blood
MH  - Drug Monitoring
MH  - Female
MH  - Humans
MH  - Immunosuppressive Agents/*administration & dosage/blood
MH  - *Liver Transplantation
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Tacrolimus/*administration & dosage/blood
EDAT- 2011/06/23 06:00
MHDA- 2011/10/15 06:00
CRDT- 2011/06/23 06:00
PHST- 2009/10/24 00:00 [received]
PHST- 2010/10/07 00:00 [revised]
PHST- 2010/11/03 00:00 [accepted]
PHST- 2011/06/23 06:00 [entrez]
PHST- 2011/06/23 06:00 [pubmed]
PHST- 2011/10/15 06:00 [medline]
AID - S0041-1345(11)00244-2 [pii]
AID - 10.1016/j.transproceed.2010.11.025 [doi]
PST - ppublish
SO  - Transplant Proc. 2011 Jun;43(5):1751-3. doi: 10.1016/j.transproceed.2010.11.025.


PMID- 21693242
OWN - NLM
STAT- MEDLINE
DCOM- 20111014
LR  - 20171116
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 43
IP  - 5
DP  - 2011 Jun
TI  - Dyslipidemia in human kidney transplant recipients receiving cyclosporine and
      tacrolimus is associated with different expression of CD36 on peripheral blood
      monocytes.
PG  - 1612-5
LID - 10.1016/j.transproceed.2011.03.015 [doi]
AB  - PURPOSE: We studied the mechanisms by which immunosuppressants result, in
      dyslipidemia among human kidney transplant recipients. METHODS: Seventy-five
      living donor kidney transplant recipients were enrolled in our study with
      informed consent and the approval of out Institutional Ethics Committee. Each
      donor-recipient pair were relatives, there were no prisoners. The serum lipid
      profile, the expression of CD36 on peripheral blood monocytes, and the whole
      blood concentrations of cyclosporine (CsA) or tacrolimus (FK506) were determined 
      at various times after transplantation. RESULTS: CsA significantly increased
      serum lipid concentrations. The CsA concentration correlated positively with
      low-density lipoprotein cholesterol (LDL) levels, whereas FK506 showed no
      significant effect on serum lipid level. There was a positive correlation between
      the CsA concentrations and the expression of CD36; FK507 showed no significant
      effect on CD36 expression. CONCLUSIONS: Hyperlipidemia in kidney transplant
      recipients treated with CsA was associated with overexpression of CD36 on
      peripheral blood monocytes.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Jiang, Y
AU  - Jiang Y
AD  - Department of Urology, Shaoyang Central Hospital, 422000, Shaoyang, Peoples
      Republic of China.
FAU - Xie, X B
AU  - Xie XB
FAU - Peng, L K
AU  - Peng LK
FAU - Peng, F H
AU  - Peng FH
FAU - Lan, G B
AU  - Lan GB
FAU - Wang, Y
AU  - Wang Y
FAU - Yu, S J
AU  - Yu SJ
FAU - Fang, C H
AU  - Fang CH
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - 0 (CD36 Antigens)
RN  - 83HN0GTJ6D (Cyclosporine)
RN  - WM0HAQ4WNM (Tacrolimus)
SB  - IM
MH  - Adult
MH  - CD36 Antigens/*immunology
MH  - Cyclosporine/*administration & dosage
MH  - Dyslipidemias/*complications
MH  - Female
MH  - Humans
MH  - *Kidney Transplantation
MH  - Male
MH  - Middle Aged
MH  - Monocytes/*drug effects/immunology
MH  - Tacrolimus/*administration & dosage
EDAT- 2011/06/23 06:00
MHDA- 2011/10/15 06:00
CRDT- 2011/06/23 06:00
PHST- 2010/11/26 00:00 [received]
PHST- 2011/01/30 00:00 [revised]
PHST- 2011/03/01 00:00 [accepted]
PHST- 2011/06/23 06:00 [entrez]
PHST- 2011/06/23 06:00 [pubmed]
PHST- 2011/10/15 06:00 [medline]
AID - S0041-1345(11)00449-0 [pii]
AID - 10.1016/j.transproceed.2011.03.015 [doi]
PST - ppublish
SO  - Transplant Proc. 2011 Jun;43(5):1612-5. doi: 10.1016/j.transproceed.2011.03.015.


PMID- 21693211
OWN - NLM
STAT- MEDLINE
DCOM- 20111014
LR  - 20220409
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 43
IP  - 5
DP  - 2011 Jun
TI  - Knowledge and attitudes toward organ/tissue donation and transplantation among
      health care professionals working in organ transplantation or dialysis units.
PG  - 1425-8
LID - 10.1016/j.transproceed.2011.01.167 [doi]
AB  - OBJECTIVE: To evaluate the awareness and attitudes of health care professionals
      toward organ/tissue donation and transplantation. METHODS: We included 309 health
      care professionals from 27 dialysis centers and eight organ transplantation
      centers in Istanbul in the present study conducted from April 2008 to August
      2008. The 24-item questionnaire, including items concerning sociodemographic
      features and knowledge about and attitudes toward organ/tissue donation and
      transplantation, was applied by face-to-face interviews. RESULTS: An organ/tissue
      donation card was completed among 77% of subjects, while 90% were identified as
      supporting transplantation. The main reasons identified for lack of donation were
      lack of confidence (59.7%), fear of procurement (31.5%), and inappropriate use of
      harvested organs (18.1%). CONCLUSION: In conclusion, targeting health care
      professionals in the first place and development of nationwide media and
      educational campaigns on the ethical, moral, as well as religious dimensions of
      transplantation and donation seem crucial to increase the number of individuals
      who can act as role models via their positive impact on the general public's
      attitudes toward organ donation.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Demir, T
AU  - Demir T
AD  - Department of Surgical Nursing, Marmara University, School of Nursing, Istanbul, 
      Turkey. tugbademir81@gmail.com
FAU - Selimen, D
AU  - Selimen D
FAU - Yildirim, M
AU  - Yildirim M
FAU - Kucuk, H F
AU  - Kucuk HF
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - *Ambulatory Care Facilities
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Health Personnel/*psychology
MH  - Humans
MH  - Male
MH  - *Organ Transplantation
MH  - *Renal Dialysis
MH  - Surveys and Questionnaires
MH  - *Tissue Donors
MH  - Turkey
MH  - Workforce
EDAT- 2011/06/23 06:00
MHDA- 2011/10/15 06:00
CRDT- 2011/06/23 06:00
PHST- 2010/07/12 00:00 [received]
PHST- 2010/11/26 00:00 [revised]
PHST- 2011/01/07 00:00 [accepted]
PHST- 2011/06/23 06:00 [entrez]
PHST- 2011/06/23 06:00 [pubmed]
PHST- 2011/10/15 06:00 [medline]
AID - S0041-1345(11)00261-2 [pii]
AID - 10.1016/j.transproceed.2011.01.167 [doi]
PST - ppublish
SO  - Transplant Proc. 2011 Jun;43(5):1425-8. doi: 10.1016/j.transproceed.2011.01.167.


PMID- 21693089
OWN - NLM
STAT- MEDLINE
DCOM- 20110908
LR  - 20211020
IS  - 0393-5264 (Print)
IS  - 0393-5264 (Linking)
VI  - 26
IP  - 1
DP  - 2011 Jan-Mar
TI  - Disorders of consciousness and communication. Ethical motivations and
      communication-enabling attributes of consciousness.
PG  - 51-4
AB  - Envisaged extensions of a functional magnetic resonance imaging (fMRI) technique 
      allowing communication with patients affected by disorders of consciousness are
      here examined in connection with subjective symptom reporting, informed consent, 
      and continued medical care decision-making. The principles of medical
      beneficence, personal autonomy protection, and the right to participate in social
      life are isolated as appropriate sources of ethical motivations for the use of
      fMRI-enabled communication. Consciousness requirements for each communication
      context are identified on the basis of qualitative distinctions between the
      access, phenomenal, and narrative varieties of consciousness. Ethically motivated
      uses of fMRI-enabled communication are hierarchically organized in terms of
      progressively more demanding consciousness requirements for successful
      communication. The outcomes of this analysis can be used to curb unrealistic
      expectations of these new scientific developments, and to promote mutual trust
      between medical doctors, patient surrogates and families.
FAU - Tamburrini, Guglielmo
AU  - Tamburrini G
AD  - Department of Physical Sciences, University of Naples Federico II, Italy.
FAU - Mattia, Donatella
AU  - Mattia D
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Funct Neurol
JT  - Functional neurology
JID - 8707746
SB  - IM
MH  - *Communication
MH  - Consciousness/*ethics
MH  - Consciousness Disorders/*physiopathology/*psychology
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Motivation/*ethics
MH  - Neuropsychological Tests
PMC - PMC3814505
EDAT- 2011/06/23 06:00
MHDA- 2011/09/09 06:00
CRDT- 2011/06/23 06:00
PHST- 2011/06/23 06:00 [entrez]
PHST- 2011/06/23 06:00 [pubmed]
PHST- 2011/09/09 06:00 [medline]
AID - 4840 [pii]
PST - ppublish
SO  - Funct Neurol. 2011 Jan-Mar;26(1):51-4.


PMID- 21693088
OWN - NLM
STAT- MEDLINE
DCOM- 20110908
LR  - 20211020
IS  - 0393-5264 (Print)
IS  - 0393-5264 (Linking)
VI  - 26
IP  - 1
DP  - 2011 Jan-Mar
TI  - Post-anoxic vegetative state: imaging and prognostic perspectives.
PG  - 45-50
AB  - Prognostic determination of patients in coma after resuscitation from cardiac
      arrest is a common and difficult requirement with significant ethical, social and
      legal implications. We set out to seek markers that can be used for the early
      detection of patients with a poor prognosis, so as to reduce uncertainty over
      treatment and non-treatment decisions, and to improve relationships with
      families. We reviewed the medical literature from 1991 to 2010, using key words
      such as post-anoxic coma, post-anoxic vegetative state, vegetative state
      prognosis, recovery after cardiac arrest. Neurological examination,
      electrophysiology, imaging, and biochemical markers are all useful tools for
      estimating patients' chances of recovery from cardiac arrest. It seems unlikely
      that any single test will prove to have 100% predictive value for outcome; but
      the combination of various prognostic markers, as shown in some articles, could
      increase the reliability of outcome prediction. However, further research is
      needed.
FAU - Stanziano, Mario
AU  - Stanziano M
AD  - Department of Public, Clinical, and Preventative Medicine, Second University of
      Naples, Italy. mariostanziano@libero.it
FAU - Foglia, Carolina
AU  - Foglia C
FAU - Soddu, Andrea
AU  - Soddu A
FAU - Gargano, Francesca
AU  - Gargano F
FAU - Papa, Michele
AU  - Papa M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - Funct Neurol
JT  - Functional neurology
JID - 8707746
RN  - 0 (Biomarkers)
SB  - IM
MH  - Biomarkers
MH  - Heart Arrest/*complications/physiopathology
MH  - Humans
MH  - Hypoxia/complications/physiopathology
MH  - Neurologic Examination/standards
MH  - Persistent Vegetative State/*diagnosis/etiology/physiopathology
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - *Recovery of Function
PMC - PMC3814506
EDAT- 2011/06/23 06:00
MHDA- 2011/09/09 06:00
CRDT- 2011/06/23 06:00
PHST- 2011/06/23 06:00 [entrez]
PHST- 2011/06/23 06:00 [pubmed]
PHST- 2011/09/09 06:00 [medline]
AID - 4839 [pii]
PST - ppublish
SO  - Funct Neurol. 2011 Jan-Mar;26(1):45-50.


PMID- 21692723
OWN - NLM
STAT- MEDLINE
DCOM- 20110831
LR  - 20220330
IS  - 1326-5377 (Electronic)
IS  - 0025-729X (Linking)
VI  - 194
IP  - 12
DP  - 2011 Jun 20
TI  - Social media and the medical profession.
PG  - 642-4
AB  - Use of social media by doctors and medical students is common and growing.
      Although professional standards and codes of ethics that govern the behaviour of 
      medical practitioners in Australia and New Zealand do not currently encompass
      social media, these codes need to evolve, because professional standards continue
      to apply in this setting. Inappropriate use of social media can result in harm to
      patients and the profession, including breaches of confidentiality, defamation of
      colleagues or employers, and violation of doctor-patient boundaries. The
      professional integrity of doctors and medical students can also be damaged
      through problematic interprofessional online relationships, and unintended
      exposure of personal information to the public, employers or universities.
      Doctors need to exercise extreme care in their use of social media to ensure they
      maintain professional standards.
FAU - Mansfield, Sarah J
AU  - Mansfield SJ
AD  - Australian Medical Association, Council of Doctors in Training, Canberra, ACT,
      Australia. s.mansfield1@gmail.com
FAU - Morrison, Stewart G
AU  - Morrison SG
FAU - Stephens, Hugh O
AU  - Stephens HO
FAU - Bonning, Michael A
AU  - Bonning MA
FAU - Wang, Sheng-Hui
AU  - Wang SH
FAU - Withers, Aaron H J
AU  - Withers AH
FAU - Olver, Rob C
AU  - Olver RC
FAU - Perry, Andrew W
AU  - Perry AW
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Med J Aust
JT  - The Medical journal of Australia
JID - 0400714
SB  - IM
MH  - Confidentiality
MH  - Ethics, Medical
MH  - Humans
MH  - Internet/*ethics
MH  - Physician-Patient Relations
MH  - Physicians/ethics/*standards
MH  - Students, Medical
EDAT- 2011/06/23 06:00
MHDA- 2011/09/01 06:00
CRDT- 2011/06/23 06:00
PHST- 2010/08/10 00:00 [received]
PHST- 2011/05/30 00:00 [accepted]
PHST- 2011/06/23 06:00 [entrez]
PHST- 2011/06/23 06:00 [pubmed]
PHST- 2011/09/01 06:00 [medline]
AID - man10874_fm [pii]
AID - 10.5694/j.1326-5377.2011.tb03149.x [doi]
PST - ppublish
SO  - Med J Aust. 2011 Jun 20;194(12):642-4. doi: 10.5694/j.1326-5377.2011.tb03149.x.


PMID- 21692618
OWN - NLM
STAT- MEDLINE
DCOM- 20111121
LR  - 20211020
IS  - 1744-8042 (Electronic)
IS  - 1462-2416 (Linking)
VI  - 12
IP  - 6
DP  - 2011 Jun
TI  - Ethical considerations for pharmacogenomic testing in pediatric clinical care and
      research.
PG  - 889-95
LID - 10.2217/pgs.10.216 [doi]
AB  - The information gained from pharmacogenomic testing is becoming increasingly
      recognized as an opportunity to improve our current dosing strategies for
      children. The identification of gene polymorphisms that influence drug
      disposition and effect can be used to help predict a child's susceptibility to
      toxicity and/or response to a particular drug or therapeutic regimen. However,
      the potential consequences of performing genomic analysis in children raise
      important ethical considerations. Although the level of risk introduced remains
      partially hypothetical, awareness of the ethical concerns and protective
      legislation will be an important part of fully informing patients, families,
      clinicians, and researchers about the risks and benefits of pharmacogenomic
      testing in children. Where it can be done without loss of benefit, risk reduction
      is a moral imperative, and so the ethical complexities related to
      pharmacogenomics must be addressed in an ongoing way as we continue to learn more
      about the value of the technology to children.
FAU - Moran, Cassandra
AU  - Moran C
AD  - Division of Pediatric Hematology Oncology, Department of Pediatrics, Duke
      University Medical Center, DUMC Box 102382, Durham, NC 27710, USA.
FAU - Thornburg, Courtney D
AU  - Thornburg CD
FAU - Barfield, Raymond C
AU  - Barfield RC
LA  - eng
GR  - UL1 RR024128/RR/NCRR NIH HHS/United States
GR  - UL1 RR024128-01/RR/NCRR NIH HHS/United States
GR  - 1UL 1RR024128-01/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - England
TA  - Pharmacogenomics
JT  - Pharmacogenomics
JID - 100897350
SB  - IM
MH  - Animals
MH  - Child
MH  - Genetic Testing/*ethics
MH  - Humans
MH  - Pediatrics/*ethics
MH  - Pharmacogenetics/*ethics
MH  - Risk Assessment/ethics
PMC - PMC3164260
MID - NIHMS311195
EDAT- 2011/06/23 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/06/23 06:00
PHST- 2011/06/23 06:00 [entrez]
PHST- 2011/06/23 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.2217/pgs.10.216 [doi]
PST - ppublish
SO  - Pharmacogenomics. 2011 Jun;12(6):889-95. doi: 10.2217/pgs.10.216.


PMID- 21692555
OWN - NLM
STAT- MEDLINE
DCOM- 20111121
LR  - 20110622
IS  - 1132-1989 (Print)
IS  - 1132-1989 (Linking)
VI  - 22
IP  - 74
DP  - 2011 Jan-Apr
TI  - [Ethic evaluation of sexual health programs on adolescence].
PG  - 77-91
AB  - In public health services, the interest in sexuality seems to turning from
      traditional topics such as potential treatments for male erectile dysfunction,
      psychosomatic disorders, the control of premature ejaculation and contraception. 
      Instead, an increasingly prominent role is being given to prevention strategies
      carried out by means of campaigns or through sexual health programme sin schools.
      The different teaching strategies that underlie these programmes, which in many
      cases lack social consensus but are often promoted by international organizations
      such as WHO or UNESCO, reveal not only divergent ethical conceptions and
      worldviews on the meaning of sexuality, but also conflicting starting points,
      means and goals, focusing either on barrier-contraceptive methods or on sexual
      abstinence and personal responsibility. There is therefore a pressing need to
      understand the scientific evidence underlying each educational approach and the
      ethical postulates of each pedagogical proposal. This paper presents an outline
      of a six-point adolescent sexuality education program, which is respectful of
      individuals' ethical convictions. Given that few works on preventive medicine
      issues include an ethical evaluation of the steps followed in their development, 
      this article also proposes a systematic evaluation of strategies for sexual
      health in the community that is developed through four steps verifying the
      following aspects: 1) the accuracy of information, 2) the level of evidence, 3)
      efficiency and 4) non-maleficence about the target population of each health
      program. The methodology used in these sexual health programs is another aspect
      that will verify their ethical consistence or, conversely, their absence of
      ethical values. We emphasize the duty of designers of programme for children not 
      to carry then out against the will of their parents or tutors, and not conceal
      sensitive and relevant information.
FAU - Jara Rascon, Jose
AU  - Jara Rascon J
AD  - Unidad de Andrologia y Medicina Sexual, Hospital General Universitario Gregorio
      Maranon, C/ Doctor Esquerdo, 46, 28007, Madrid. jjara@terra.es
FAU - Alonso Sandoica, Esmeralda
AU  - Alonso Sandoica E
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Valoracion Etica de los Programas de Salud Sexual en la Adolescencia.
PL  - Spain
TA  - Cuad Bioet
JT  - Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y
      Etica Medica
JID - 101312976
SB  - IM
MH  - *Adolescent
MH  - Adolescent Behavior
MH  - American Medical Association
MH  - Contraception
MH  - Culture
MH  - Female
MH  - Guidelines as Topic
MH  - Humans
MH  - Male
MH  - Pregnancy
MH  - Pregnancy in Adolescence
MH  - Sex Education/*ethics
MH  - Sexual Behavior
MH  - Sexually Transmitted Diseases/prevention & control
MH  - Social Responsibility
MH  - Social Values
MH  - United Nations
MH  - United States
EDAT- 2011/06/23 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/06/23 06:00
PHST- 2010/10/17 00:00 [received]
PHST- 2011/02/05 00:00 [accepted]
PHST- 2011/06/23 06:00 [entrez]
PHST- 2011/06/23 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PST - ppublish
SO  - Cuad Bioet. 2011 Jan-Apr;22(74):77-91.


PMID- 21692554
OWN - NLM
STAT- MEDLINE
DCOM- 20111121
LR  - 20110622
IS  - 1132-1989 (Print)
IS  - 1132-1989 (Linking)
VI  - 22
IP  - 74
DP  - 2011 Jan-Apr
TI  - [Noninvasive prenatal genetic diagnosis: a bioethical reflection on the use of
      noninvasive prenatal diagnosis from the analysis of nucleic acids present in
      maternal peripheral blood].
PG  - 49-75
AB  - The use of techniques that analyse the fetal nucleic acids present in maternal
      peripheral blood for the preparation of non-invasive prenatal genetic diagnosis, 
      is a clinical reality in the case of certain diseases. In the coming years, it
      will become part of the routine monitoring for fetal diagnosis. This study
      analyzes the current status of these techniques as well as the major ethical
      issues arising from the relationship between - prenatal diagnosis and eugenic
      abortion, and the specific problems posed by - prenatal genetic diagnosis based
      an analysis of the nucleic acids present in maternal peripheral blood. Among the 
      conclusions are the following: we make a positive ethical evaluation of the
      technique when it is aimed at pregnant women who are in a situation of high risk,
      defined on the basis of medical standards and ethics, without compromising the
      integrity of the fetus. We make a negative ethical evaluation when non-invasive
      prenatal genetic diagnosis has a eugenic purpose and will establish a connection 
      between prenatal diagnosis and eugenic abortion in case of a positive result.
      Non-invasive prenatal diagnosis increases the image of the disabled person as an 
      individual that has to be excluded from society. The widespread use of
      non-invasive prenatal diagnosis will decrease the autonomy of women / couples
      when it comes to making decisions. Health authorities may use non-invasive
      prenatal diagnosis as a way of ''preventing'' genetic diseases, since it will
      lower costs, increase the number of malformed fetuses detected and a decrease the
      number of indirect abortions involving invasive techniques.
FAU - Gonzalez-Melado, Fermin J
AU  - Gonzalez-Melado FJ
AD  - Pontificio Istituto Giovanni Paolo II. Piazza S. Giovanni in Laterano, 4. 00120
      Citta del Vaticano. ferminjgm@hotmail.com
FAU - Di Pietro, Maria Luisa
AU  - Di Pietro ML
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Diagnostico Prenatal Genetico No Invasivo: Reflexion Bioetica Sobre la
      Utilizacion del Diagnostico Prenatal No Invasivo a Partir del Analisis de Acidos 
      Nucleicos Presentes en Sangre Periferica Materna.
PL  - Spain
TA  - Cuad Bioet
JT  - Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y
      Etica Medica
JID - 101312976
RN  - 63231-63-0 (RNA)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Abortion, Eugenic/ethics
MH  - DNA/*blood
MH  - Disabled Persons
MH  - Down Syndrome/diagnosis/embryology/genetics/prevention & control
MH  - Female
MH  - Fetomaternal Transfusion/*blood
MH  - Genetic Counseling
MH  - Genetic Diseases, Inborn/diagnosis/embryology/epidemiology/genetics/prevention & 
      control
MH  - Genetic Testing
MH  - Health Policy
MH  - Humans
MH  - Informed Consent
MH  - Intention
MH  - Pregnancy
MH  - Prenatal Diagnosis/*ethics/methods
MH  - RNA/*blood
MH  - Sex Determination Analysis/ethics/methods
MH  - Social Values
EDAT- 2011/06/23 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/06/23 06:00
PHST- 2010/09/06 00:00 [received]
PHST- 2011/02/07 00:00 [accepted]
PHST- 2011/06/23 06:00 [entrez]
PHST- 2011/06/23 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PST - ppublish
SO  - Cuad Bioet. 2011 Jan-Apr;22(74):49-75.


PMID- 21692553
OWN - NLM
STAT- MEDLINE
DCOM- 20111121
LR  - 20120323
IS  - 1132-1989 (Print)
IS  - 1132-1989 (Linking)
VI  - 22
IP  - 74
DP  - 2011 Jan-Apr
TI  - [Ethical analysis and commentary of Dignitas Personae document: from continuity
      toward the innovation].
PG  - 25-46
AB  - In 2008 [corrected] the Catholic Church published a document entitled Dignitas
      Personae (DP) about a range of bioethical issues related to the areas of assisted
      reproduction and human genetics. The objective of this paper is analyzing the
      issues treated in the same and comments the novelty of his arguments in the
      bioethical thinking of the Catholic Church. DP document has an introduction,
      three parts and a conclusion. The publication of document is due to recent
      advances that have occurred in recent years in the two areas mentioned above.
      This advances were not analyzed in a previously document called Donum Vitae (DV).
      DP analyzes these new advances from the anthropological and ethical approaches of
      DV. Not intending to contradict DV, the DP applies the arguments of DV to new
      situations. In both the title and elsewhere in the text it is affirmed that the
      human embryo has the dignity of human person. From this principle DP analyzes
      issues such as the status of the human embryo, intracytoplasmic sperm injection, 
      (ICSI), preimplantation diagnosis, embryo cryopreservation, contragestion, embryo
      reduction etc. In these matters, as in the questions such as human genetics,
      cloning, gene therapy or the use of biological material obtained from abortions, 
      the document reaffirms previous ideas of the Catholic Church, applies them to new
      problems or develops new arguments that will require further reflection. In
      conclusion, the document is very useful for understanding the current bioethical 
      thinking of the Catholic Church on these issues; it clarifies certain disputes,
      suggesting new arguments, and leaves other issues to free discussion and
      subsequent interventions of the Catholic Magisterium. Finally, the document
      reaffirms the commitment of the Catholic Church to the poor of our
      techno-scientific society, the proletariat of the new century: human embryos.
FAU - Pastor, Luis Miguel
AU  - Pastor LM
AD  - Departamento de Biologia Celular e Histologia, Facultad de Medicina, Universidad 
      de Murcia, Campus de Espinardo 30100, Murcia, Espana. bioetica@um.es
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Analisis y Comentario Etico del Documento Dignitas Personae: Desde la Continuidad
      a la Novedad.
PL  - Spain
TA  - Cuad Bioet
JT  - Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y
      Etica Medica
JID - 101312976
SB  - IM
EIN - Cuad Bioet. 2011 Sep-Dec;22(76):629
MH  - Abortion, Induced/ethics
MH  - Beginning of Human Life
MH  - *Bioethical Issues
MH  - *Catholicism
MH  - Cloning, Organism/ethics
MH  - Cryopreservation/ethics
MH  - Dissent and Disputes
MH  - Embryo Disposition/ethics
MH  - Embryo Research/*ethics
MH  - *Ethical Analysis
MH  - Female
MH  - Genetic Enhancement/ethics
MH  - Genetic Techniques/*ethics
MH  - Humans
MH  - Male
MH  - Morals
MH  - Oocytes
MH  - *Personhood
MH  - Pregnancy
MH  - Preimplantation Diagnosis/ethics
MH  - Reproductive Techniques, Assisted/*ethics
EDAT- 2011/06/23 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/06/23 06:00
PHST- 2011/02/04 00:00 [received]
PHST- 2011/03/30 00:00 [accepted]
PHST- 2011/06/23 06:00 [entrez]
PHST- 2011/06/23 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PST - ppublish
SO  - Cuad Bioet. 2011 Jan-Apr;22(74):25-46.


PMID- 21692311
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20110621
IS  - 1660-9379 (Print)
IS  - 1660-9379 (Linking)
VI  - 7
IP  - 294
DP  - 2011 May 11
TI  - [Indications for PCR in travel medicine].
PG  - 991-2, 994
AB  - The use of PCR-based molecular diagnosis in travel medicine remains limited to
      specific indications such as clinical suspicion of some of the viral hemorrhagic 
      fevers (e.g. Ebola, Marburg), differential diagnosis between Entamoeba
      histolytica (pathogen) and E. dispar (non pathogen) in the stools, and
      parasitological diagnosis of cutaneous leishmaniasis. The scope of indications is
      likely to expand in the coming years with the development of techniques (e.g.
      multiplex PCR) able to identify several pathogens from a single sample.
      Simplification and cost-reduction of molecular techniques, which would allow for 
      more equitable access to these diagnostic tools in countries where the targeted
      diseases are highly prevalent, pose major technological and ethical challenges.
FAU - Chappuis, F
AU  - Chappuis F
AD  - Service de medecine internationale et humanitaire, Departement de medecine
      communautaire, de premier recours et des urgences HUG, 1211 Geneve 14.
      francois.chappuis@hcuge.ch
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Place de la PCR en medecine des voyages.
PL  - Switzerland
TA  - Rev Med Suisse
JT  - Revue medicale suisse
JID - 101219148
SB  - IM
MH  - Diarrhea/etiology
MH  - Humans
MH  - Leishmaniasis, Cutaneous/diagnosis
MH  - Malaria/diagnosis
MH  - *Polymerase Chain Reaction
MH  - *Travel Medicine
EDAT- 2011/06/23 06:00
MHDA- 2011/07/27 06:00
CRDT- 2011/06/23 06:00
PHST- 2011/06/23 06:00 [entrez]
PHST- 2011/06/23 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
PST - ppublish
SO  - Rev Med Suisse. 2011 May 11;7(294):991-2, 994.


PMID- 21692305
OWN - NLM
STAT- MEDLINE
DCOM- 20110804
LR  - 20110621
IS  - 0255-2930 (Print)
IS  - 0255-2930 (Linking)
VI  - 31
IP  - 5
DP  - 2011 May
TI  - [Story life CHENG Dan-an's, works and his achievements on acupuncture and
      moxibustion science].
PG  - 467-72
AB  - Mr. CHENG Dan-an, who devoted himself to the renaissance of the course of modern 
      Chinese acupuncture, the establishment of acupuncture education unit,
      correspondence education, acupuncture personnel fostering and publication of
      periodicals on acupuncture, has great contribution to the academic exchanges and 
      popularization of acupuncture. Mr. CHENG has completed over 10 articles and more 
      than 20 works and translations. According to him, mechanism on meridians,
      collaterals, acupoints and acupuncture techniques were explored with the
      promotion on application of "Shen" and "qi" in clinic. Pulse and tongue diagnosis
      as well as acupuncture treatment were supplemented into Shanghanlun (Treatise on 
      Febrile Diseases). And great importance was attached on the scientific validity
      and practicability. His professional ethics and dedication are worth to be
      learned by all medical workers nowadays. His acupuncture theories and academic
      achievements still inspire us today, which are also taken as the origin for the
      innovation and development of modern acupuncture science.
FAU - Lu, Xiang
AU  - Lu X
AD  - Anhui College of TCM, Teaching and Research Section of Medical History and
      Literature, Hefei 230038, China. ahluxiang@126.com
FAU - Cai, Yue
AU  - Cai Y
LA  - chi
PT  - Biography
PT  - English Abstract
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Zhen Jiu
JT  - Zhongguo zhen jiu = Chinese acupuncture & moxibustion
JID - 8600658
SB  - IM
MH  - Achievement
MH  - Acupuncture/education/*history
MH  - China
MH  - History, 19th Century
MH  - History, 20th Century
MH  - Humans
MH  - Moxibustion/*history
MH  - Publications
MH  - Teaching
PS  - CHENG DA
FPS - CHENG, Dan-an
EDAT- 2011/06/23 06:00
MHDA- 2011/08/05 06:00
CRDT- 2011/06/23 06:00
PHST- 2011/06/23 06:00 [entrez]
PHST- 2011/06/23 06:00 [pubmed]
PHST- 2011/08/05 06:00 [medline]
PST - ppublish
SO  - Zhongguo Zhen Jiu. 2011 May;31(5):467-72.


PMID- 21692194
OWN - NLM
STAT- MEDLINE
DCOM- 20120125
LR  - 20161125
IS  - 1099-0496 (Electronic)
IS  - 1099-0496 (Linking)
VI  - 46
IP  - 10
DP  - 2011 Oct
TI  - Chest radiographic presenting features and radiographic progression of
      pneumocystis pneumonia in South African children.
PG  - 1015-22
LID - 10.1002/ppul.21465 [doi]
AB  - PURPOSE: To describe the radiographic features of PCP in South African children, 
      including the progression of changes and the impact of HIV-infection and
      respiratory co-infections. METHODS: A paediatric radiologist blinded to clinical 
      details retrospectively reported the chest radiographs of children diagnosed with
      PCP at a South Africa paediatric hospital between January 2003 and June 2006
      inclusive. Radiographic features were correlated with clinical findings and
      compared using Fisher's exact test and Wilcoxon's ranks-sum test. Institutional
      ethics approval was obtained. RESULTS: Of 113 cases of PCP, 110 (97.3%) had
      presenting and 96 (84.9%) follow-up radiographs; 88 (82%) were HIV-infected; 65
      (59%) had respiratory co-infection; 48 (43%) died in hospital. The commonest
      presenting radiographic findings were increased lung volumes (n = 86; 78%) and
      diffuse parenchymal opacification (n = 70; 64%); 89 (92.7%) ultimately progressed
      to diffuse alveolar opacification. Median time to maximum pulmonary opacification
      was 72 hours (inter-quartile range (IQR): 24-144 hrs). Pulmonary interstitial
      emphysema (PIE) developed in 33 patients (30%). There was no significant
      difference in the radiographic features of PCP when comparison was made between
      i) HIV-infected and -uninfected children, ii) those with and without respiratory 
      co-infection and iii) fatal cases and survivors (P > 0.05 in all cases).
      CONCLUSION: Increased lung volumes and PIE should be recognised as features of
      PCP in South African children. HIV-infection and respiratory co-infections do not
      influence the radiographic features of PCP in our setting.
CI  - Copyright (c) 2011 Wiley-Liss, Inc.
FAU - Pitcher, Richard D
AU  - Pitcher RD
AD  - Division of Radiodiagnosis, Department of Medical Imaging and Clinical Oncology, 
      Tygerberg Academic Hospital, University of Stellenbosch, Cape Town, South Africa.
      pitcher@sun.ac.za
FAU - Daya, Rupesh
AU  - Daya R
FAU - Beningfield, Stephen J
AU  - Beningfield SJ
FAU - Zar, Heather J
AU  - Zar HJ
LA  - eng
PT  - Journal Article
DEP - 20110620
PL  - United States
TA  - Pediatr Pulmonol
JT  - Pediatric pulmonology
JID - 8510590
SB  - IM
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - HIV Infections/complications
MH  - Humans
MH  - Infant
MH  - Male
MH  - Pneumonia, Pneumocystis/complications/*diagnostic imaging
MH  - Radiography
MH  - Retrospective Studies
MH  - South Africa
EDAT- 2011/06/22 06:00
MHDA- 2012/01/26 06:00
CRDT- 2011/06/22 06:00
PHST- 2010/09/02 00:00 [received]
PHST- 2010/12/23 00:00 [accepted]
PHST- 2011/06/22 06:00 [entrez]
PHST- 2011/06/22 06:00 [pubmed]
PHST- 2012/01/26 06:00 [medline]
AID - 10.1002/ppul.21465 [doi]
PST - ppublish
SO  - Pediatr Pulmonol. 2011 Oct;46(10):1015-22. doi: 10.1002/ppul.21465. Epub 2011 Jun
      20.


PMID- 21691688
OWN - NLM
STAT- MEDLINE
DCOM- 20120928
LR  - 20160815
IS  - 1806-9282 (Electronic)
IS  - 0104-4230 (Linking)
VI  - 57
IP  - 3
DP  - 2011 May-Jun
TI  - Ethical standards adopted by Brazilian journals of medical specialties.
PG  - 264-8
LID - S0104-42302011000300007 [pii]
AB  - OBJECTIVE: To review ethical standards contained in guidelines to authors of
      Brazilian scientific journals in several medical specialties and see if there is 
      any standardization available. METHODS: This is an exploratory study evaluating
      Brazilian scientific journals classified on the Portal of Journals on Health
      Sciences of the Virtual Health Library in all medical specialties regarding
      guidelines to authors submitting manuscripts and concerning ethical standards for
      research in humans. Data was collected and categorized for the presence of the
      following variables: Ethics Committee approval; Helsinki Declaration and/or
      Resolution 196/96, informed consent; ethical standards; uniform requirements;
      patients' confidentiality and no ethical references. The association among the
      variables was also examined. RESULTS: Out of a total of 8,701 journals, 95 were
      included in the current study. The variables were investigated, with each one's
      frequency being verified. Eighty per cent were referred for an Ethics Committee
      approval; 43.15% of Helsinki Declaration; 43.15% of informed consent; 9.47% of
      ethical standards; 32.63% of uniform requirements and 15.78% of patients'
      confidentiality were referenced. In the whole sampling, 9.47% of journals do not 
      mention any ethical reference as a guide to authors submitting manuscripts. An
      association among variables occurred in 61% of the sample. CONCLUSION: Ethical
      aspects of submitting manuscripts were mentioned in over 90% of the guides to
      authors of national scientific journals and no standardization at all is
      available.
FAU - Fernandes, Marcos Rassi
AU  - Fernandes MR
AD  - Departamento de Ortopedia, Faculdade de Medicina, Universidade Federal de Goias, 
      Goiania, GO, Brazil. marcosombro@ig.com.br
FAU - Queiroz, Maria Conceicao Castro Antonelli Monteiro
AU  - Queiroz MC
FAU - de Moraes, Maria Rosedalia
AU  - de Moraes MR
FAU - Barbosa, Maria Alves
AU  - Barbosa MA
FAU - Sousa, Ana Luiza Lima
AU  - Sousa AL
LA  - eng
LA  - por
PT  - Journal Article
PL  - Brazil
TA  - Rev Assoc Med Bras (1992)
JT  - Revista da Associacao Medica Brasileira (1992)
JID - 9308586
SB  - IM
MH  - Brazil
MH  - Confidentiality/ethics
MH  - Ethics Committees, Research
MH  - *Ethics, Medical
MH  - Ethics, Research
MH  - Humans
MH  - Informed Consent/ethics
MH  - *Medicine
MH  - Periodicals as Topic/*ethics
MH  - Therapeutic Human Experimentation/*ethics
EDAT- 2011/06/22 06:00
MHDA- 2012/09/29 06:00
CRDT- 2011/06/22 06:00
PHST- 2010/08/16 00:00 [received]
PHST- 2011/02/18 00:00 [accepted]
PHST- 2011/06/22 06:00 [entrez]
PHST- 2011/06/22 06:00 [pubmed]
PHST- 2012/09/29 06:00 [medline]
AID - S0104-42302011000300007 [pii]
PST - ppublish
SO  - Rev Assoc Med Bras (1992). 2011 May-Jun;57(3):264-8.


PMID- 21691683
OWN - NLM
STAT- MEDLINE
DCOM- 20120928
LR  - 20160815
IS  - 1806-9282 (Electronic)
IS  - 0104-4230 (Linking)
VI  - 57
IP  - 3
DP  - 2011 May-Jun
TI  - Ethical considerations in collective health.
PG  - 246-52
LID - S0104-42302011000300002 [pii]
FAU - Santana, Vilma Souza
AU  - Santana VS
AD  - Instituto de Saude Coletiva, Universidade Federal da Bahia, Salvador, Brazil.
      vilma@ufba.br
FAU - de Castilho, Euclides Ayres
AU  - de Castilho EA
LA  - eng
LA  - por
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Brazil
TA  - Rev Assoc Med Bras (1992)
JT  - Revista da Associacao Medica Brasileira (1992)
JID - 9308586
SB  - IM
MH  - Brazil
MH  - Conflict of Interest
MH  - Cultural Characteristics
MH  - Epidemiology/*ethics/legislation & jurisprudence
MH  - *Ethics, Research
MH  - Human Experimentation/*ethics/legislation & jurisprudence
MH  - Humans
MH  - Patient Rights/*ethics
MH  - Personal Autonomy
MH  - Public Health/ethics
EDAT- 2011/06/22 06:00
MHDA- 2012/09/29 06:00
CRDT- 2011/06/22 06:00
PHST- 2011/06/22 06:00 [entrez]
PHST- 2011/06/22 06:00 [pubmed]
PHST- 2012/09/29 06:00 [medline]
AID - S0104-42302011000300002 [pii]
PST - ppublish
SO  - Rev Assoc Med Bras (1992). 2011 May-Jun;57(3):246-52.


PMID- 21691675
OWN - NLM
STAT- MEDLINE
DCOM- 20120522
LR  - 20170410
IS  - 2511-705X (Electronic)
IS  - 0026-1270 (Linking)
VI  - 51
IP  - 1
DP  - 2012
TI  - Multidimensional point transform for public health practice.
PG  - 63-73
LID - 10.3414/ME11-01-0001 [doi]
AB  - BACKGROUND: With increases in spatial information and enabling technologies,
      location-privacy concerns have been on the rise. A commonly proposed solution in 
      public health involves random perturbation, however consideration for individual 
      dimensions (attributes) has been weak. OBJECTIVES: The current study proposes a
      multidimensional point transform (MPT) that integrates the spatial dimension with
      other dimensions of interest to comprehensively anonymise data. METHODS: The MPT 
      relies on the availability of a base population, a subset patient dataset, and
      shared dimensions of interest. Perturbation distance and anonymity thresholds are
      defined, as are allowable dimensional perturbations. A preliminary implementation
      is presented using sex, age and location as the three dimensions of interest,
      with a maximum perturbation distance of 1 kilometre and an anonymity threshold of
      20%. A synthesised New York county population is used for testing with 1000
      iterations for each of 25, 50, 100, 200 and 400 patient dataset sizes. RESULTS:
      The MPT consistently yielded a mean perturbation distance of 46 metres with no
      sex or age perturbation required. Displacement of the spatial mean decreased with
      patient dataset size and averaged 5.6 metres overall. CONCLUSIONS: The MPT
      presents a flexible, customisable and adaptive algorithm for perturbing datasets 
      for public health, allowing tweaking and optimisation of the trade-offs for
      different datasets and purposes. It is not, however, a substitute for secure and 
      ethical conduct, and a public health framework for the appropriate disclosure,
      use and dissemination of data containing personal identifiable information is
      required. The MPT presents an important component of such a framework.
FAU - AbdelMalik, P
AU  - AbdelMalik P
AD  - Faculty of Health and Education, University of Plymouth, Drake Circus, Plymouth, 
      Devon, PL4 8AA, UK. philip.abdelmalik@plymouth.ac.uk
FAU - Kamel Boulos, M N
AU  - Kamel Boulos MN
LA  - eng
PT  - Journal Article
DEP - 20110621
PL  - Germany
TA  - Methods Inf Med
JT  - Methods of information in medicine
JID - 0210453
SB  - IM
MH  - Age Factors
MH  - Algorithms
MH  - Female
MH  - Geography
MH  - Humans
MH  - Male
MH  - New York
MH  - *Privacy
MH  - *Public Health Practice
MH  - Risk
MH  - Sex Factors
EDAT- 2011/06/22 06:00
MHDA- 2012/05/23 06:00
CRDT- 2011/06/22 06:00
PHST- 2011/01/11 00:00 [received]
PHST- 2011/05/10 00:00 [accepted]
PHST- 2011/06/22 06:00 [entrez]
PHST- 2011/06/22 06:00 [pubmed]
PHST- 2012/05/23 06:00 [medline]
AID - 11-01-0001 [pii]
AID - 10.3414/ME11-01-0001 [doi]
PST - ppublish
SO  - Methods Inf Med. 2012;51(1):63-73. doi: 10.3414/ME11-01-0001. Epub 2011 Jun 21.


PMID- 21691419
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 1741-0541 (Print)
IS  - 1741-0541 (Linking)
VI  - 8
IP  - 1
DP  - 2011 Jan
TI  - Biobanking in pediatrics: the human nonsubjects approach.
PG  - 79
AB  - Pediatric biobanks are an indispensible resource for the research that will be
      needed to bring advances in personalized medicine into pediatric medical care.
      Investigators developing pediatric biobanks have struggled with the ethical and
      legal challenges that arise in pediatric research. This article explores how one 
      biobank model, the 'human nonsubjects models', is able to respond to such common 
      challenges as the role of the parent and the child in agreeing to research
      participation, reconsent at the age of majority, data sharing and return of
      research results. Although this approach does not involve formal informed
      consent, it is well-suited to pediatric biobanking owing to its potential to
      reduce risk to children through a combination of advanced deidentification
      techniques and extensive oversight.
FAU - Brothers, Kyle Bertram
AU  - Brothers KB
AD  - Center for Biomedical Ethics & Society, 2525 West End Ave., Suite 400, Nashville,
      TN 37203, USA, Tel.: +1 615 936 2686.
LA  - eng
GR  - UL1 RR024975-01/RR/NCRR NIH HHS/United States
GR  - KL2 RR024977/RR/NCRR NIH HHS/United States
GR  - UL1 RR024975/RR/NCRR NIH HHS/United States
GR  - U01 HG004603/HG/NHGRI NIH HHS/United States
GR  - TL1 RR024978/RR/NCRR NIH HHS/United States
GR  - U01 HG004603-03/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PL  - England
TA  - Per Med
JT  - Personalized medicine
JID - 101238549
PMC - PMC3117295
MID - NIHMS296041
EDAT- 2011/06/22 06:00
MHDA- 2011/06/22 06:01
CRDT- 2011/06/22 06:00
PHST- 2011/06/22 06:00 [entrez]
PHST- 2011/06/22 06:00 [pubmed]
PHST- 2011/06/22 06:01 [medline]
AID - 10.2217/pme.10.70 [doi]
PST - ppublish
SO  - Per Med. 2011 Jan;8(1):79. doi: 10.2217/pme.10.70.


PMID- 21691271
OWN - NLM
STAT- MEDLINE
DCOM- 20110823
LR  - 20211020
IS  - 1532-6535 (Electronic)
IS  - 0009-9236 (Linking)
VI  - 90
IP  - 1
DP  - 2011 Jul
TI  - Practical ethics: establishing a pathway to benefit for complex pharmacogenomic
      tests.
PG  - 25-7
LID - 10.1038/clpt.2011.71 [doi]
AB  - Pharmacogenomic tests offer a promising strategy to improve the safety and
      efficacy of drug treatment. Compelling examples, such as HLA-B*5701 testing to
      identify patients at risk for abacavir-associated hypersensitivity, are already
      changing clinical care. However, the level of evidence required to establish
      clinical utility is often the subject of debate. Determining the most efficient
      and effective pathway to benefit for a given test is therefore both a practical
      and an ethical concern.
FAU - Haga, S B
AU  - Haga SB
AD  - Institute for Genome Sciences & Policy, Duke University, Durham, North Carolina, 
      USA.
FAU - Burke, W
AU  - Burke W
LA  - eng
GR  - R01 GM081416/GM/NIGMS NIH HHS/United States
GR  - R01 GM081416-05/GM/NIGMS NIH HHS/United States
GR  - U01 GM092676-02/GM/NIGMS NIH HHS/United States
GR  - U01 GM092676/GM/NIGMS NIH HHS/United States
GR  - U01GM092676/GM/NIGMS NIH HHS/United States
GR  - R01GM081416/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Clin Pharmacol Ther
JT  - Clinical pharmacology and therapeutics
JID - 0372741
RN  - 0 (Biomarkers)
SB  - IM
MH  - Biomarkers
MH  - Drug Therapy
MH  - Drug-Related Side Effects and Adverse Reactions
MH  - Gene Expression Profiling
MH  - Genetic Testing
MH  - Humans
MH  - Molecular Biology
MH  - Pharmacogenetics/*ethics
MH  - Precision Medicine
PMC - PMC3234687
MID - NIHMS339031
EDAT- 2011/06/22 06:00
MHDA- 2011/08/24 06:00
CRDT- 2011/06/22 06:00
PHST- 2011/06/22 06:00 [entrez]
PHST- 2011/06/22 06:00 [pubmed]
PHST- 2011/08/24 06:00 [medline]
AID - clpt201171 [pii]
AID - 10.1038/clpt.2011.71 [doi]
PST - ppublish
SO  - Clin Pharmacol Ther. 2011 Jul;90(1):25-7. doi: 10.1038/clpt.2011.71.


PMID- 21691022
OWN - NLM
STAT- MEDLINE
DCOM- 20111025
LR  - 20151119
IS  - 0975-5764 (Electronic)
IS  - 0975-5764 (Linking)
VI  - 10
IP  - 2
DP  - 2011 Apr-Jun
TI  - Survey of medical specialists on their attitudes to and resources for health
      research in Nigeria.
PG  - 144-9
LID - 10.4103/1596-3519.82078 [doi]
AB  - AIM: To study the views of medical specialists on their attitude to and the
      resources for health research in Nigeria and draw appropriate policy
      implications. MATERIALS AND METHODS: Structured questionnaires were distributed
      to consenting 90 randomly selected medical specialists practising in six Nigerian
      tertiary health institutions. Participants' background information, importance
      attached to research, motivations for conducting research, funding, ethical
      oversight, literature search, and statistical support were probed. The coded
      responses were stored and analyzed using the statistical SPSS software. RESULTS: 
      Fifty-one out of the 90 questionnaires distributed were returned, giving a
      response rate of 63.3%. Research function was rated third by 64.7% of the
      respondents after hospital service (72.5%) and teaching (66.0%). Advancement of
      knowledge was the strongest motivating factor for conducting research (78.4%).
      Securing funding (94%) and finding time (80%) were their major constraints. Only 
      a minority of the respondents, 20% and 14%, respectfully, positively rated the
      quality and promptness of the decisions of their institutions' ethical organs in 
      the highest category. Most of their literature search was conducted on the
      internet (96.1%) and they stored and analyzed their research data with commonly
      available statistical software. CONCLUSION: Our study respondents regarded
      research highly but were severely constrained in conducting research by lack of
      access to sources of funding from within and outside Nigeria and finding time
      from core hospital functions. We recommend periodic (re)training in research
      particularly on how to apply for research grants and giving some protected
      research time for Nigerian medical specialists in order to boost their research
      function.
FAU - Mahmoud, Abdulraheem O
AU  - Mahmoud AO
AD  - Department of Ophthalmology, University of Ilorin Teaching Hospital, Ilorin,
      Nigeria. mahmoud_ao@yahoo.com
FAU - Ayanniyi, Adeyinka A
AU  - Ayanniyi AA
FAU - Lawal, Abdul
AU  - Lawal A
FAU - Omolase, Charles O
AU  - Omolase CO
FAU - Ologunsua, Yinka
AU  - Ologunsua Y
FAU - Samaila, Elsie
AU  - Samaila E
LA  - eng
PT  - Journal Article
PL  - India
TA  - Ann Afr Med
JT  - Annals of African medicine
JID - 101231417
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Biomedical Research/*organization & administration
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - *Health Resources
MH  - Health Services Research
MH  - Humans
MH  - Male
MH  - Motivation
MH  - Nigeria
MH  - *Physicians
MH  - *Research Support as Topic
MH  - Surveys and Questionnaires
EDAT- 2011/06/22 06:00
MHDA- 2011/10/26 06:00
CRDT- 2011/06/22 06:00
PHST- 2011/06/22 06:00 [entrez]
PHST- 2011/06/22 06:00 [pubmed]
PHST- 2011/10/26 06:00 [medline]
AID - AnnAfrMed_2011_10_2_144_82078 [pii]
AID - 10.4103/1596-3519.82078 [doi]
PST - ppublish
SO  - Ann Afr Med. 2011 Apr-Jun;10(2):144-9. doi: 10.4103/1596-3519.82078.


PMID- 21690229
OWN - NLM
STAT- MEDLINE
DCOM- 20120501
LR  - 20120123
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 2
DP  - 2012 Feb
TI  - What do patients expect from their physicians? Qualitative research on the
      ethical aspects of patient statements.
PG  - 112-6
LID - 10.1136/jme.2010.038026 [doi]
AB  - This study aimed to examine the thoughts and expectations of patients receiving
      healthcare from their physicians and evaluate the ethical aspects of these
      thoughts and expectations. To determine the ethical aspects of the thoughts and
      expectations of patients, an open-ended question was asked on the web page of the
      Turkish Armed Forces (TAF) Health Care Command, which is accessible to the users 
      of the TAF intranet system (the internet system used within TAF institutions).
      The participants were asked to express their thoughts in their own words. A total
      of 804 participants answered the question by providing their input. The
      statements of the participants were classified separately by two public health
      specialists. The classification was made in accordance with the basic principles 
      of patient rights, and they were collected under various headings including
      expectations about respect and care, good communication, informed consent, and
      fair and non-privileged distribution of healthcare services. The results show
      that patients tend to consider the physicians they see as solely responsible for 
      all the negative issues that they encounter during their healthcare. This
      indicates that there is a need for extensive research on the underlying factors
      involved in the negative thoughts and feelings toward healthcare professionals in
      both TAF and Turkey in general.
FAU - Cetin, Mehmet
AU  - Cetin M
AD  - Gulhane Askeri Tip Akademisi, Askeri Saglik Hizmetleri, Etlik, Ankara, Turkey.
      mcetin6457@gmail.com
FAU - Ucar, Muharrem
AU  - Ucar M
FAU - Guven, Tolga
AU  - Guven T
FAU - Atac, Adnan
AU  - Atac A
FAU - Ozer, Mustafa
AU  - Ozer M
LA  - eng
PT  - Journal Article
DEP - 20110620
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Adult
MH  - Attitude of Health Personnel
MH  - Communication
MH  - Cross-Sectional Studies
MH  - Female
MH  - Health Care Surveys
MH  - Health Services Accessibility
MH  - Humans
MH  - Informed Consent
MH  - Internet
MH  - Male
MH  - Military Medicine/*standards
MH  - Military Personnel/*psychology
MH  - Patient Rights/*ethics
MH  - Patient Satisfaction
MH  - *Physician-Patient Relations
MH  - Qualitative Research
MH  - Turkey
EDAT- 2011/06/22 06:00
MHDA- 2012/05/02 06:00
CRDT- 2011/06/22 06:00
PHST- 2011/06/22 06:00 [entrez]
PHST- 2011/06/22 06:00 [pubmed]
PHST- 2012/05/02 06:00 [medline]
AID - jme.2010.038026 [pii]
AID - 10.1136/jme.2010.038026 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Feb;38(2):112-6. doi: 10.1136/jme.2010.038026. Epub 2011 Jun
      20.


PMID- 21689441
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1472-6955 (Electronic)
IS  - 1472-6955 (Linking)
VI  - 10
DP  - 2011 Jun 20
TI  - The nursing staff's opinion of falls among older persons with dementia. a
      cross-sectional study.
PG  - 13
LID - 10.1186/1472-6955-10-13 [doi]
AB  - UNLABELLED: The aim of this study was to describe the nursing staff's opinion of 
      caring for older persons with dementia with the focus on causes of falls,
      fall-preventing interventions, routines of documentation and report and the
      nursing staff's experiences and reactions when fall incidents occur. A further
      aim was to compare these areas between registered nurses (RNs) and enrolled
      nurses (ENs) and staff with </=5 and >5 years of employment in the care units in 
      question. BACKGROUND: Falls are common among older people and persons with
      dementia constitute an additional risk group. METHODS: The study had a
      cross-sectional design and included nursing staff (n = 63, response rate 66%)
      working in four special care units for older persons with dementia. Data
      collection was conducted with a questionnaire consisting of 64 questions.
      RESULTS: The respondents reported that the individuals' mental and physical
      impairment constitute the most frequent causes of falls. The findings also
      revealed a lack of, or uncertainty about, routines of documentation and reporting
      fall-risk and fall-preventing interventions. Respondents who had been employed in
      the care units more than five years reported to a higher degree that colours and 
      material on floors caused falls. RNs considered the residents' autonomy and
      freedom of movement as a cause of falls to a significantly higher degree than
      ENs. RNs also reported a significantly longer time than ENs before fall incidents
      were discovered, and they used conversation and closeness as fall-preventing
      interventions to a significantly higher degree than ENs. CONCLUSIONS: Individual 
      factors were the most common causes to falls according to the nursing staff. RNs 
      used closeness and dialog as interventions to a significantly higher degree to
      prevent falls than ENs. Caring of for older people with dementia consisted of a
      comprehensive on-going assessment by the nursing staff to balance the residents' 
      autonomy-versus-control to minimise fall-risk. This ethical dilemma should
      initiate development of feasible routines of systematic risk-assessment, report
      and documentation.
FAU - Struksnes, Solveig
AU  - Struksnes S
AD  - Associate professor, Center of Care Research, Department of Health, Care and
      Nursing, Gjovik University College, 2815 Gjovik, Norway.
FAU - Bachrach-Lindstrom, Margareta
AU  - Bachrach-Lindstrom M
AD  - Associate Professor, Faculty of Health Sciences, Department of Medicine and Care,
      Division of Nursing Science, Linkoping University, 58183 Linkoping, Sweden.
FAU - Hall-Lord, Marie Louise
AU  - Hall-Lord ML
AD  - Professor in Nursing, Center of Care Research, Department of Health, Care and
      Nursing, Gjovik University College, 2815 Gjovik, Norway.
AD  - Faculty of Social and Life Sciences, Karlstad University, 65188 Karlstad, Sweden.
FAU - Slaasletten, Randi
AU  - Slaasletten R
AD  - Associate professor, Center of Care Research, Department of Health, Care and
      Nursing, Gjovik University College, 2815 Gjovik, Norway.
FAU - Johansson, Inger
AU  - Johansson I
AD  - Professor in Nursing, Center of Care Research, Department of Health, Care and
      Nursing, Gjovik University College, 2815 Gjovik, Norway.
AD  - Faculty of Social and Life Sciences, Karlstad University, 65188 Karlstad, Sweden.
LA  - eng
PT  - Journal Article
DEP - 20110620
PL  - England
TA  - BMC Nurs
JT  - BMC nursing
JID - 101088683
PMC - PMC3142214
EDAT- 2011/06/22 06:00
MHDA- 2011/06/22 06:01
CRDT- 2011/06/22 06:00
PHST- 2010/09/01 00:00 [received]
PHST- 2011/06/20 00:00 [accepted]
PHST- 2011/06/22 06:00 [entrez]
PHST- 2011/06/22 06:00 [pubmed]
PHST- 2011/06/22 06:01 [medline]
AID - 1472-6955-10-13 [pii]
AID - 10.1186/1472-6955-10-13 [doi]
PST - epublish
SO  - BMC Nurs. 2011 Jun 20;10:13. doi: 10.1186/1472-6955-10-13.


PMID- 21689429
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1755-7682 (Electronic)
IS  - 1755-7682 (Linking)
VI  - 4
DP  - 2011 Jun 20
TI  - Institutional review boards - a mixed blessing.
PG  - 19
LID - 10.1186/1755-7682-4-19 [doi]
AB  - Institutional Review Boards (IRBs) are an important checkpoint for all types of
      research in medicine. Although these bodies originated primarily in the developed
      world, they have special contemporary consideration in the context of developing 
      countries due to the large number of clinical trials being conducted in these
      regions with the financial support of large pharmaceutical companies. IRBs are
      vital to ensure that all scientific investigation is conducted in a manner that
      is transparent, scientifically feasible and ethically sound. However, they have
      also been variably criticized for introducing unnecessary and often protracted
      bureaucracy and red tape into the system. There is a need to reorganize and
      better delineate the exact functions of the IRBs in view of the dynamic changes
      in the realm of research so that they can function in a more efficient, judicious
      and effective fashion.
FAU - Saleem, Taimur
AU  - Saleem T
AD  - Medical College, Aga Khan University, Stadium Road, Karachi 74800, Pakistan.
      taimur@gmail.com.
FAU - Khalid, Umair
AU  - Khalid U
LA  - eng
PT  - Journal Article
DEP - 20110620
PL  - England
TA  - Int Arch Med
JT  - International archives of medicine
JID - 101317943
PMC - PMC3130653
EDAT- 2011/06/22 06:00
MHDA- 2011/06/22 06:01
CRDT- 2011/06/22 06:00
PHST- 2011/04/13 00:00 [received]
PHST- 2011/06/20 00:00 [accepted]
PHST- 2011/06/22 06:00 [entrez]
PHST- 2011/06/22 06:00 [pubmed]
PHST- 2011/06/22 06:01 [medline]
AID - 1755-7682-4-19 [pii]
AID - 10.1186/1755-7682-4-19 [doi]
PST - epublish
SO  - Int Arch Med. 2011 Jun 20;4:19. doi: 10.1186/1755-7682-4-19.


PMID- 21689412
OWN - NLM
STAT- MEDLINE
DCOM- 20111026
LR  - 20211020
IS  - 1471-2458 (Electronic)
IS  - 1471-2458 (Linking)
VI  - 11
DP  - 2011 Jun 20
TI  - Optimizing diffusion of an online computer tailored lifestyle program: a study
      protocol.
PG  - 480
LID - 10.1186/1471-2458-11-480 [doi]
AB  - BACKGROUND: Although the Internet is a promising medium to offer lifestyle
      interventions to large amounts of people at relatively low costs and effort,
      actual exposure rates of these interventions fail to meet the high expectations. 
      Since public health impact of interventions is determined by intervention
      efficacy and level of exposure to the intervention, it is imperative to put
      effort in optimal dissemination. The present project attempts to optimize the
      dissemination process of a new online computer tailored generic lifestyle program
      by carefully studying the adoption process and developing a strategy to achieve
      sustained use of the program. METHODS/DESIGN: A prospective study will be
      conducted to yield relevant information concerning the adoption process by
      studying the level of adoption of the program, determinants involved in adoption 
      and characteristics of adopters and non-adopters as well as satisfied and
      unsatisfied users. Furthermore, a randomized control trial will be conducted to
      the test the effectiveness of a proactive strategy using periodic e-mail prompts 
      in optimizing sustained use of the new program. DISCUSSION: Closely mapping the
      adoption process will gain insight in characteristics of adopters and
      non-adopters and satisfied and unsatisfied users. This insight can be used to
      further optimize the program by making it more suitable for a wider range of
      users, or to develop adjusted interventions to attract subgroups of users that
      are not reached or satisfied with the initial intervention. Furthermore, by
      studying the effect of a proactive strategy using period prompts compared to a
      reactive strategy to stimulate sustained use of the intervention and, possibly,
      behaviour change, specific recommendations on the use and the application of
      prompts in online lifestyle interventions can be developed. TRIAL REGISTRATION:
      Dutch Trial Register NTR1786 and Medical Ethics Committee of Maastricht
      University and the University Hospital Maastricht (NL2723506809/MEC0903016).
FAU - Schneider, Francine
AU  - Schneider F
AD  - CAPHRI/Department of Health Promotion, Maastricht University, P,O, Box 616, 6200 
      MD Maastricht, the Netherlands. francine.schneider@maastrichtuniversity.nl
FAU - van Osch, Liesbeth A D M
AU  - van Osch LA
FAU - Kremers, Stef P J
AU  - Kremers SP
FAU - Schulz, Daniela N
AU  - Schulz DN
FAU - van Adrichem, Mathieu J G
AU  - van Adrichem MJ
FAU - de Vries, Hein
AU  - de Vries H
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110620
PL  - England
TA  - BMC Public Health
JT  - BMC public health
JID - 100968562
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Consumer Behavior
MH  - *Diffusion of Innovation
MH  - Female
MH  - Health Behavior
MH  - Health Promotion/*methods
MH  - Humans
MH  - *Internet
MH  - *Life Style
MH  - Male
MH  - Middle Aged
MH  - Netherlands
MH  - Prospective Studies
MH  - *User-Computer Interface
MH  - Young Adult
PMC - PMC3130675
EDAT- 2011/06/22 06:00
MHDA- 2011/10/27 06:00
CRDT- 2011/06/22 06:00
PHST- 2011/05/27 00:00 [received]
PHST- 2011/06/20 00:00 [accepted]
PHST- 2011/06/22 06:00 [entrez]
PHST- 2011/06/22 06:00 [pubmed]
PHST- 2011/10/27 06:00 [medline]
AID - 1471-2458-11-480 [pii]
AID - 10.1186/1471-2458-11-480 [doi]
PST - epublish
SO  - BMC Public Health. 2011 Jun 20;11:480. doi: 10.1186/1471-2458-11-480.


PMID- 21689114
OWN - NLM
STAT- MEDLINE
DCOM- 20120522
LR  - 20120124
IS  - 1467-9566 (Electronic)
IS  - 0141-9889 (Linking)
VI  - 34
IP  - 1
DP  - 2012 Jan
TI  - Neuroculture, active ageing and the 'older brain': problems, promises and
      prospects.
PG  - 64-78
LID - 10.1111/j.1467-9566.2011.01364.x [doi]
AB  - This article explores the characteristics of a newly emergent 'neuroculture' and 
      its relationship to cultures of ageing; in particular, the social meanings
      associated with 'active ageing' and 'cognitive health' and the discourses and
      sciences around memory and the 'ageing brain'. The argument proposes a critical
      perspective on this relationship by looking at the shifting boundaries between
      standards of normality and abnormality, values of health and illness, practices
      of therapy and enhancement, and the lines demarcating Third Age (healthy, active 
      and agentic) and Fourth Age (dependency, loss and decline) periods of ageing.
      Conclusions offer further reflections on the complex questions that arise
      regarding expectations, hopes and ethics in relation to the promises and perils
      of a neurocultural future.
CI  - (c) 2011 The Authors. Sociology of Health & Illness (c) 2011 Foundation for the
      Sociology of Health & Illness/Blackwell Publishing Ltd.
FAU - Williams, Simon J
AU  - Williams SJ
AD  - Department of Sociology, University of Warwick, Coventry, UK.
      s.j.williams@warwick.ac.uk
FAU - Higgs, Paul
AU  - Higgs P
FAU - Katz, Stephen
AU  - Katz S
LA  - eng
PT  - Journal Article
DEP - 20110620
PL  - England
TA  - Sociol Health Illn
JT  - Sociology of health & illness
JID - 8205036
SB  - IM
MH  - Aging/physiology/*psychology
MH  - Brain/*physiopathology
MH  - Cognition Disorders/psychology
MH  - *Culture
MH  - Humans
MH  - Memory Disorders/psychology
MH  - Sociology, Medical
EDAT- 2011/06/22 06:00
MHDA- 2012/05/23 06:00
CRDT- 2011/06/22 06:00
PHST- 2011/06/22 06:00 [entrez]
PHST- 2011/06/22 06:00 [pubmed]
PHST- 2012/05/23 06:00 [medline]
AID - 10.1111/j.1467-9566.2011.01364.x [doi]
PST - ppublish
SO  - Sociol Health Illn. 2012 Jan;34(1):64-78. doi: 10.1111/j.1467-9566.2011.01364.x. 
      Epub 2011 Jun 20.


PMID- 21689076
OWN - NLM
STAT- MEDLINE
DCOM- 20120316
LR  - 20181201
IS  - 1399-6576 (Electronic)
IS  - 0001-5172 (Linking)
VI  - 55
IP  - 9
DP  - 2011 Oct
TI  - Determining authorship in multicenter trials: a systematic review.
PG  - 1037-43
LID - 10.1111/j.1399-6576.2011.02477.x [doi]
AB  - The practical and ethical issues in determining authorship in multicenter trials 
      raise significant and unique challenges. This systematic review examines methods 
      of assigning authorship in multicenter clinical trials. A literature search
      (October 2009) was conducted to identify articles with the terms 'authorship' and
      'clinical trial,' 'multicenter' or 'multicentre.' Abstracts were reviewed for
      potential relevance and the complete manuscript was obtained where indicated.
      Additional articles were identified by a review of the reference list from
      sourced articles. Methods for determining authorship were reviewed in terms of
      practicality, fairness and the time course for decision-making. Eight methods for
      determining authorship were identified: four used a scoring system, two articles 
      contained guidelines with reference to scoring systems and two articles outlined 
      general guidelines. All methods attempted to provide a fair and practical
      approach and appeared to achieve this to varying degrees. No one method was
      applicable across all multicenter trials. The authors propose a guide for
      determining authorship based on the methods identified and the number of
      collaborators and anticipated publications. For smaller collaborative groups
      (e.g. <10 persons), byline inclusion of all authors based on relative
      contributions is recommended. For larger collaborations (e.g. >/= 10 persons),
      authorship guidelines should be explicit from the outset of the trial with
      consideration of relevant scoring systems.
CI  - 2011 The Authors. Acta Anaesthesiologica Scandinavica, 2011 The Acta
      Anaesthesiologica Scandinavica Foundation.
FAU - Dulhunty, J M
AU  - Dulhunty JM
AD  - Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital,
      Herston, Qld, Australia. joel_dulhunty@health.qld.gov.au
FAU - Boots, R J
AU  - Boots RJ
FAU - Paratz, J D
AU  - Paratz JD
FAU - Lipman, J
AU  - Lipman J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20110620
PL  - England
TA  - Acta Anaesthesiol Scand
JT  - Acta anaesthesiologica Scandinavica
JID - 0370270
SB  - IM
MH  - *Authorship
MH  - Humans
MH  - *Multicenter Studies as Topic
EDAT- 2011/06/22 06:00
MHDA- 2012/03/17 06:00
CRDT- 2011/06/22 06:00
PHST- 2011/06/22 06:00 [entrez]
PHST- 2011/06/22 06:00 [pubmed]
PHST- 2012/03/17 06:00 [medline]
AID - 10.1111/j.1399-6576.2011.02477.x [doi]
PST - ppublish
SO  - Acta Anaesthesiol Scand. 2011 Oct;55(9):1037-43. doi:
      10.1111/j.1399-6576.2011.02477.x. Epub 2011 Jun 20.


PMID- 21688676
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20110620
IS  - 1660-9379 (Print)
IS  - 1660-9379 (Linking)
VI  - 7
IP  - 295
DP  - 2011 May 18
TI  - [Scientific research in family medicine: practitioners' experience, barriers and 
      needs].
PG  - 1089-92, 1094
AB  - Scientific data from family medicine are relevant for the majority of the
      population. They are therefore essential from an ethical and public health
      perspective. We need to promote quality research in family medicine despite
      methodological, financial and logistic barriers. To highlight the strengths and
      weaknesses of research in family medicine in the French-speaking part of
      Switzerland we asked practitioners from this region to share their experience,
      critics and needs in relation to research. This article summarizes their
      contribution in light of the international literature.
FAU - Haller, D M
AU  - Haller DM
AD  - Unite de recherche et d'enseignement en medecine de premier recours, Universite
      de Geneve. dagmar.haller-hester@hcuge.ch
FAU - Jotterand, S
AU  - Jotterand S
FAU - Durrer, D
AU  - Durrer D
FAU - Sebo, P
AU  - Sebo P
FAU - Birchmeier, A
AU  - Birchmeier A
FAU - Lefebvre, D
AU  - Lefebvre D
FAU - Raetzo, M-A
AU  - Raetzo MA
FAU - Ruiz Lachat, M J
AU  - Ruiz Lachat MJ
FAU - Klauser, P
AU  - Klauser P
FAU - Jaussi, A
AU  - Jaussi A
FAU - Marthe, R
AU  - Marthe R
FAU - Martin-du-Pan, R
AU  - Martin-du-Pan R
FAU - Rieder, A
AU  - Rieder A
FAU - Herzig, L
AU  - Herzig L
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Recherche scientifique en medecine de famille: experiences, barrieres et besoins 
      des praticiens.
PL  - Switzerland
TA  - Rev Med Suisse
JT  - Revue medicale suisse
JID - 101219148
SB  - IM
MH  - *Family Practice
MH  - Humans
MH  - *Needs Assessment
MH  - *Research
EDAT- 2011/06/22 06:00
MHDA- 2011/07/27 06:00
CRDT- 2011/06/22 06:00
PHST- 2011/06/22 06:00 [entrez]
PHST- 2011/06/22 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
PST - ppublish
SO  - Rev Med Suisse. 2011 May 18;7(295):1089-92, 1094.


PMID- 21688428
OWN - NLM
STAT- MEDLINE
DCOM- 20110718
LR  - 20110620
IS  - 1173-2032 (Print)
IS  - 1173-2032 (Linking)
VI  - 17
IP  - 3
DP  - 2011 Apr
TI  - Author breaches ethics.
PG  - 4-5; author reply 5
FAU - Sharpe, Graham
AU  - Sharpe G
LA  - eng
PT  - Letter
PL  - New Zealand
TA  - Nurs N Z
JT  - Nursing New Zealand (Wellington, N.Z. : 1995)
JID - 9507374
MH  - Holistic Nursing/*standards/*trends
MH  - Homeopathy/*standards/*trends
MH  - Humans
MH  - New Zealand
MH  - *Placebo Effect
EDAT- 2011/06/21 06:00
MHDA- 2011/07/19 06:00
CRDT- 2011/06/21 06:00
PHST- 2011/06/21 06:00 [entrez]
PHST- 2011/06/21 06:00 [pubmed]
PHST- 2011/07/19 06:00 [medline]
PST - ppublish
SO  - Nurs N Z. 2011 Apr;17(3):4-5; author reply 5.


PMID- 21688247
OWN - NLM
STAT- MEDLINE
DCOM- 20111220
LR  - 20181201
IS  - 1724-6059 (Electronic)
IS  - 1121-8428 (Linking)
VI  - 24
IP  - 4
DP  - 2011 Jul-Aug
TI  - Nephrology around Europe: organization models and management strategies: Spain.
PG  - 438-45
LID - 10.5301/JN.2011.8428 [doi]
AB  - The main aim of this report is to present a picture of the current organization
      of nephrology in Spain. The Spanish health system offers almost universal
      coverage, a wide variety of services and a high-quality network of hospitals and 
      primary care centers. Spain has a specialized health care training system that is
      highly developed, highly regulated, with the capacity to provide high-quality
      training in 54 different specialties. Nephrology is basically a hospital-based
      specialty. There are no private dialysis patients in Spain. Hemodialysis centers 
      are 40% public, 15% private and 45% run by companies. The National Health System 
      covers 95% of the population, and there is no cost to patients for treatment of
      renal disease (dialysis and transplant). We observed a clear decrease of
      nephrology in residents' election rankings, with position 29 out of 47
      specialties in 2007. Some of the reasons for this are the complexity of the
      subject, no clear information at the university, reduction of professional posts 
      and a very good public service with minimal private practice. In Spain, a model
      of organization for transplantation was adopted based on a decentralized
      transplant coordinating network. For cadaveric donors, it compares favorably with
      rates in other Western countries. Living donor transplantation is very low in
      Spain--just 10% of total renal transplantation activity. New programs due to
      financial constraints need to include reduced dialysis costs, greater
      cost-effectiveness of prescriptions, better handling of ethical issues related to
      the need for using a clinical score of chronic kidney disease patients to make
      decisions about conservative or renal replacement therapy and an action plan for 
      improvement of organ donation and transplantation. Recovery of skills (acute
      kidney injury, biopsies, vascular access, etc.), research and advances in
      autonomous activities (imaging, surgical and medical vascular training, etc.) are
      some of the future educational paths needed in nephrology. Adequate decisions in 
      the context of economic restrictions need to be discussed for the sustainability 
      of nephrological care.
FAU - de Francisco, Angel L M
AU  - de Francisco AL
AD  - Servicio de Nefrologia, Valdecilla Universitary Hospital, Universidad de
      Cantabria, REDinRed, Santander, Spain. angelmartindefrancisco@gmail.com
FAU - Pinera, Celestino
AU  - Pinera C
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - J Nephrol
JT  - Journal of nephrology
JID - 9012268
SB  - IM
MH  - Career Choice
MH  - Humans
MH  - *Kidney Transplantation
MH  - Nephrology/economics/education/*organization & administration
MH  - *Renal Dialysis
MH  - Spain
MH  - Tissue and Organ Procurement/*organization & administration
MH  - Workforce
EDAT- 2011/06/21 06:00
MHDA- 2011/12/21 06:00
CRDT- 2011/06/21 06:00
PHST- 2011/02/02 00:00 [accepted]
PHST- 2011/06/21 06:00 [entrez]
PHST- 2011/06/21 06:00 [pubmed]
PHST- 2011/12/21 06:00 [medline]
AID - 6F3DE6FD-BA1A-4198-B5D8-6610C5304974 [pii]
AID - 10.5301/JN.2011.8428 [doi]
PST - ppublish
SO  - J Nephrol. 2011 Jul-Aug;24(4):438-45. doi: 10.5301/JN.2011.8428.


PMID- 21687846
OWN - NLM
STAT- MEDLINE
DCOM- 20111101
LR  - 20131121
IS  - 1473-0189 (Electronic)
IS  - 1473-0189 (Linking)
VI  - 11
IP  - 15
DP  - 2011 Aug 7
TI  - Monitoring cellular stress responses to nanoparticles using a lab-on-a-chip.
PG  - 2551-60
LID - 10.1039/c1lc20256a [doi]
AB  - As nanotechnology moves towards widespread commercialization, new technologies
      are needed to adequately address the potential health impact of nanoparticles
      (NPs). Assessing the safety of over 30,000 NPs through animal testing would not
      only be expensive, but it would also raise a number of ethical considerations.
      Furthermore, existing in vitro cell-based assays are not sufficient in scope to
      adequately address the complexity of cell-nanoparticle interactions including NP 
      translocation, accumulation and co-transport of e.g. allergens. In particular,
      classical optical/fluorescent endpoint detection methods are known to provide
      irreproducible, inaccurate and unreliable results since these labels can directly
      react with the highly catalytic surfaces of NP. To bridge this technological gap 
      we have developed a lab-on-a-chip capable of continuously and non-invasively
      monitoring the collagen production of primary human fibroblast cells (NHDF) using
      contactless dielectric microsensors. Human dermal fibroblast cells are
      responsible for the maintenance of soft tissue integrity, are found throughout
      the human body and their primary function is collagen expression. We show that
      cellular collagen production can be readily detected and used to assess cellular 
      stress responses to a variety of external stimuli, including exposure to
      nanoparticles. Results of the study showed a 20% and 95% reduction of collagen
      production following 4 hour exposure to 10 mug mL(-1) gold and silver
      nanoparticles (dia.10 nm), respectively. Furthermore a prolonged perfusion of
      sub-toxic concentrations (0.1 mug mL(-1)) of silver NP reduced NHDF collagen
      production by 40% after 10 h indicating increased NP take up and accumulation. We
      demonstrate that the application of microfluidics for the tailored administration
      of different NP treatments constitutes a powerful new tool to study
      cell-nanoparticle interactions and nanoparticle accumulation effects in small
      cell populations.
CI  - This journal is (c) The Royal Society of Chemistry 2011
FAU - Richter, Lukas
AU  - Richter L
AD  - Department of Health & Environment, Nano Systems, Austrian Institute of
      Technology (AIT), Donau-City Street 1, 1220 Vienna, Austria.
FAU - Charwat, Verena
AU  - Charwat V
FAU - Jungreuthmayer, Christian
AU  - Jungreuthmayer C
FAU - Bellutti, Florian
AU  - Bellutti F
FAU - Brueckl, Hubert
AU  - Brueckl H
FAU - Ertl, Peter
AU  - Ertl P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110617
PL  - England
TA  - Lab Chip
JT  - Lab on a chip
JID - 101128948
RN  - 3M4G523W1G (Silver)
RN  - 7440-57-5 (Gold)
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Cells, Cultured
MH  - Collagen/*biosynthesis
MH  - Fibroblasts/*cytology/*metabolism
MH  - Gold/pharmacology
MH  - Humans
MH  - *Metal Nanoparticles
MH  - *Microfluidic Analytical Techniques/instrumentation/methods
MH  - Silver/pharmacology
MH  - *Stress, Physiological
MH  - Time Factors
EDAT- 2011/06/21 06:00
MHDA- 2011/11/02 06:00
CRDT- 2011/06/21 06:00
PHST- 2011/06/21 06:00 [entrez]
PHST- 2011/06/21 06:00 [pubmed]
PHST- 2011/11/02 06:00 [medline]
AID - 10.1039/c1lc20256a [doi]
PST - ppublish
SO  - Lab Chip. 2011 Aug 7;11(15):2551-60. doi: 10.1039/c1lc20256a. Epub 2011 Jun 17.


PMID- 21687711
OWN - NLM
STAT- MEDLINE
DCOM- 20111014
LR  - 20211020
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 6
IP  - 6
DP  - 2011
TI  - Analyzing media coverage of the global fund diseases compared with lower funded
      diseases (childhood pneumonia, diarrhea and measles).
PG  - e20438
LID - 10.1371/journal.pone.0020438 [doi]
AB  - BACKGROUND: Pneumonia, diarrhea and measles are the leading causes of death in
      children worldwide, but have a disproportionately low share of international
      funding and media attention. In comparison, AIDS, tuberculosis and
      malaria--diseases that also significantly affect children--receive considerably
      more funding and have relatively high media coverage. This study investigates the
      potential relationship between media agenda setting and funding levels in the
      context of the actual burden of disease. METHODS: The news databases Lexis Nexis,
      Factiva, and Google News Archive were searched for the diseases AIDS, TB and
      Malaria and for lower funded pediatric diseases: childhood pneumonia, diarrhea,
      and measles. A sample of news articles across geographic regions was also
      analyzed using a qualitative narrative frame analysis of how the media stories
      were told. RESULTS: There were significantly more articles addressing the Global 
      Fund diseases compared to the lower funded pediatric diseases between 1981 and
      2008 (1,344,150 versus 291,865 articles). There were also notable differences in 
      the framing of media narratives: 1) There was a high proportion of articles with 
      the primary purpose of raising awareness for AIDS, TB and malaria (46.2%)
      compared with only 17.9% of the pediatric disease articles. 2) Nearly two-thirds 
      (61.5%) of the AIDS, tuberculosis and malaria articles used a human rights, legal
      or social justice frame, compared with 46.2% for the lower funded pediatric
      disease articles, which primarily used an ethical or moral frame. CONCLUSION:
      This study demonstrates that lower funded pediatric diseases are presented
      differently in the media, both quantitatively and qualitatively, than higher
      funded, higher profile diseases.
FAU - Hudacek, David L
AU  - Hudacek DL
AD  - Center for Global Health and Development, Boston University, Boston,
      Massachusetts, United States of America. dhudacek@gmail.com
FAU - Kuruvilla, Shyama
AU  - Kuruvilla S
FAU - Kim, Nora
AU  - Kim N
FAU - Semrau, Katherine
AU  - Semrau K
FAU - Thea, Donald
AU  - Thea D
FAU - Qazi, Shamim
AU  - Qazi S
FAU - Pleasant, Andrew
AU  - Pleasant A
FAU - Shanahan, James
AU  - Shanahan J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20110608
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/economics
MH  - Child
MH  - Child, Preschool
MH  - Communications Media/*statistics & numerical data
MH  - Diarrhea/economics
MH  - Humans
MH  - *Internationality
MH  - Malaria/economics
MH  - Measles/economics
MH  - Neglected Diseases/*economics
MH  - Pneumonia/economics
MH  - Public Policy
MH  - Tuberculosis/economics
PMC - PMC3110621
EDAT- 2011/06/21 06:00
MHDA- 2011/10/15 06:00
CRDT- 2011/06/21 06:00
PHST- 2010/09/25 00:00 [received]
PHST- 2011/05/03 00:00 [accepted]
PHST- 2011/06/21 06:00 [entrez]
PHST- 2011/06/21 06:00 [pubmed]
PHST- 2011/10/15 06:00 [medline]
AID - 10.1371/journal.pone.0020438 [doi]
AID - PONE-D-10-02375 [pii]
PST - ppublish
SO  - PLoS One. 2011;6(6):e20438. doi: 10.1371/journal.pone.0020438. Epub 2011 Jun 8.


PMID- 21687686
OWN - NLM
STAT- MEDLINE
DCOM- 20111014
LR  - 20211020
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 6
IP  - 6
DP  - 2011
TI  - One universal common endpoint in mouse models of amyotrophic lateral sclerosis.
PG  - e20582
LID - 10.1371/journal.pone.0020582 [doi]
AB  - There is no consensus among research laboratories around the world on the
      criteria that define endpoint in studies involving rodent models of amyotrophic
      lateral sclerosis (ALS). Data from 4 nutrition intervention studies using 162
      G93A mice, a model of ALS, were analyzed to determine if differences exist
      between the following endpoint criteria: CS 4 (functional paralysis of both
      hindlimbs), CS 4+ (CS 4 in addition to the earliest age of body weight loss, body
      condition deterioration or righting reflex), and CS 5 (CS 4 plus righting reflex 
      >20 s). The age (d; mean +/- SD) at which mice reached endpoint was recorded as
      the unit of measurement. Mice reached CS 4 at 123.9+/-10.3 d, CS 4+ at
      126.6+/-9.8 d and CS 5 at 127.6+/-9.8 d, all significantly different from each
      other (P<0.001). There was a significant positive correlation between CS 4 and CS
      5 (r = 0.95, P<0.001), CS 4 and CS 4+ (r = 0.96, P<0.001), and CS 4+ and CS 5 (r 
      = 0.98, P<0.001), with the Bland-Altman plot showing an acceptable bias between
      all endpoints. Logrank tests showed that mice reached CS 4 24% and 34% faster
      than CS 4+ (P = 0.046) and CS 5 (P = 0.006), respectively. Adopting CS 4 as
      endpoint would spare a mouse an average of 4 days (P<0.001) from further
      neuromuscular disability and poor quality of life compared to CS 5.
      Alternatively, CS 5 provides information regarding proprioception and severe
      motor neuron death, both could be important parameters in establishing the
      efficacy of specific treatments. Converging ethics and discovery, would adopting 
      CS 4 as endpoint compromise the acquisition of insight about the effects of
      interventions in animal models of ALS?
FAU - Solomon, Jesse A
AU  - Solomon JA
AD  - School of Kinesiology and Health Science, Faculty of Health, York University,
      Toronto, Ontario, Canada.
FAU - Tarnopolsky, Mark A
AU  - Tarnopolsky MA
FAU - Hamadeh, Mazen J
AU  - Hamadeh MJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110608
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - EC 1.15.1.1 (SOD1 G93A protein)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Amyotrophic Lateral Sclerosis/genetics/*physiopathology
MH  - Animals
MH  - *Disease Models, Animal
MH  - Endpoint Determination/*methods
MH  - Female
MH  - Hindlimb/physiopathology
MH  - Male
MH  - Mice
MH  - Mice, Transgenic
MH  - Paralysis/physiopathology
MH  - Reflex, Righting/physiology
MH  - Reproducibility of Results
MH  - Stress, Psychological/prevention & control
MH  - Superoxide Dismutase/genetics
MH  - Survival Analysis
PMC - PMC3110799
EDAT- 2011/06/21 06:00
MHDA- 2011/10/15 06:00
CRDT- 2011/06/21 06:00
PHST- 2010/08/31 00:00 [received]
PHST- 2011/05/05 00:00 [accepted]
PHST- 2011/06/21 06:00 [entrez]
PHST- 2011/06/21 06:00 [pubmed]
PHST- 2011/10/15 06:00 [medline]
AID - 10.1371/journal.pone.0020582 [doi]
AID - PONE-D-10-00968 [pii]
PST - ppublish
SO  - PLoS One. 2011;6(6):e20582. doi: 10.1371/journal.pone.0020582. Epub 2011 Jun 8.


PMID- 21685658
OWN - NLM
STAT- MEDLINE
DCOM- 20111018
LR  - 20110620
IS  - 0926-9630 (Print)
IS  - 0926-9630 (Linking)
VI  - 167
DP  - 2011
TI  - A comparison of client characteristics in cyber and in-person counseling.
PG  - 149-53
AB  - As cybertherapy diversifies into a wide variety of modalities, it is incumbent
      upon researchers and clinicians to determine the most suitable cybertherapy
      approach for clients. Suitability encompasses ethical considerations, client
      satisfaction, and treatment outcomes. The authors, working with an Employee and
      Family Assistance Program provider based in Canada, provided text-based e-mail
      counseling (cybercounseling) to clients across the country. Cybercounseling was
      accessible to clients through the same avenues as in-person counseling. Clients
      self-selected either cybercounseling or in-person counseling at intake. For the
      purposes of this study, data from 211 clients have been collected, including 105 
      online and 106 in-person clients. Client demographic data including age, gender, 
      presenting problem, referral source and marital status were collected for each
      client. Comparing the cyber and in-person client data provides insights into the 
      similarities and differences between cyber and in-person client groups.
FAU - Murphy, Lawrence
AU  - Murphy L
AD  - Worldwide Therapy Online Inc, ON, Canada. research@sympatico.ca
FAU - Mitchell, Dan
AU  - Mitchell D
FAU - Hallett, Rebecca
AU  - Hallett R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Stud Health Technol Inform
JT  - Studies in health technology and informatics
JID - 9214582
MH  - Adult
MH  - Age Factors
MH  - Counseling/*methods
MH  - Female
MH  - Humans
MH  - *Internet
MH  - Male
MH  - Middle Aged
MH  - Referral and Consultation
MH  - Sex Factors
MH  - Socioeconomic Factors
MH  - Telemedicine/*statistics & numerical data
EDAT- 2011/06/21 06:00
MHDA- 2011/10/19 06:00
CRDT- 2011/06/21 06:00
PHST- 2011/06/21 06:00 [entrez]
PHST- 2011/06/21 06:00 [pubmed]
PHST- 2011/10/19 06:00 [medline]
PST - ppublish
SO  - Stud Health Technol Inform. 2011;167:149-53.


PMID- 21685628
OWN - NLM
STAT- MEDLINE
DCOM- 20110802
LR  - 20131121
IS  - 0926-9630 (Print)
IS  - 0926-9630 (Linking)
VI  - 166
DP  - 2011
TI  - Impact evaluation of innovative technology: estimating the impact of the PSIP
      solutions.
PG  - 227-33
AB  - Health informatics projects often develop innovative IT solutions for health
      care. Systematic evaluation of their impact and risks is an ethical imperative.
      However, field studies can often not be conducted because of immature solutions. 
      On the other site, lab studies are not helpful when it comes to estimating the
      impact of an innovative IT solution. We faced this challenge within the PSIP
      projects where innovative tools for medication management are developed. In this 
      paper, we present the approaches used within the PSIP project for estimating the 
      impact of immature solutions, including surveys of future users, a Delphi study
      with experts, and a simulation study. The methodology and first results of those 
      evaluations are presented, and lessons learnt for impact evaluation of immature
      solutions are discussed.
FAU - Ammenwerth, Elske
AU  - Ammenwerth E
AD  - Institute for Health Information Systems, UMIT - University for Health Sciences, 
      Medical Informatics and Technology, Hall in Tyrol, Austria.
      elske.ammenwerth@umit.at
FAU - Hackl, Werner O
AU  - Hackl WO
FAU - Jensen, Sanne
AU  - Jensen S
FAU - Lawton, Kitta
AU  - Lawton K
FAU - Riedmann, Daniel
AU  - Riedmann D
FAU - Jung, Martin
AU  - Jung M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Stud Health Technol Inform
JT  - Studies in health technology and informatics
JID - 9214582
MH  - *Computer Simulation
MH  - *Creativity
MH  - Decision Support Systems, Clinical/organization & administration
MH  - Delphi Technique
MH  - Drug-Related Side Effects and Adverse Reactions/prevention & control
MH  - Humans
MH  - Information Systems/*organization & administration
MH  - Safety Management/organization & administration
MH  - *Software Design
MH  - *Software Validation
EDAT- 2011/06/21 06:00
MHDA- 2011/08/04 06:00
CRDT- 2011/06/21 06:00
PHST- 2011/06/21 06:00 [entrez]
PHST- 2011/06/21 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
PST - ppublish
SO  - Stud Health Technol Inform. 2011;166:227-33.


PMID- 21685148
OWN - NLM
STAT- MEDLINE
DCOM- 20120501
LR  - 20120123
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 2
DP  - 2012 Feb
TI  - Informed consent for clinical trials of deep brain stimulation in psychiatric
      disease: challenges and implications for trial design.
PG  - 107-11
LID - 10.1136/jme.2010.042002 [doi]
AB  - Advances in neuromodulation and an improved understanding of the anatomy and
      circuitry of psychopathology have led to a resurgence of interest in surgery for 
      psychiatric disease. Clinical trials exploring deep brain stimulation (DBS), a
      focally targeted, adjustable and reversible form of neurosurgery, are being
      developed to address the use of this technology in highly selected patient
      populations. Psychiatric patients deemed eligible for surgical intervention, such
      as DBS, typically meet stringent inclusion criteria, including demonstrated
      severity, chronicity and a failure of conventional therapy. Although a
      humanitarian device exemption by the US Food and Drug Administration exists for
      its use in obsessive-compulsive disorder, DBS remains a largely experimental
      treatment in the psychiatric context, with its use currently limited to clinical 
      trials and investigative studies. The combination of a patient population at the 
      limits of conventional therapy and a novel technology in a new indication poses
      interesting challenges to the informed consent process as it relates to clinical 
      trial enrollment. These challenges can be divided into those that relate to the
      patient, their disease and the technology, with each illustrating how traditional
      conceptualisations of research consent may be inadequate in the surgical
      psychiatry context. With specific reference to risk analysis, patient autonomy,
      voluntariness and the duty of the clinician-researcher, this paper will discuss
      the unique challenges that clinical trials of surgery for refractory psychiatric 
      disease present to the consent process. Recommendations are also made for an
      ethical approach to clinical trial consent acquisition in this unique patient
      population.
FAU - Lipsman, Nir
AU  - Lipsman N
AD  - Division of Neurosurgery, Toronto Western Hospital, University Health Network,
      399 Bathurst Street, Toronto, ON, Canada. nir.lipsman@utoronto.ca
FAU - Giacobbe, Peter
AU  - Giacobbe P
FAU - Bernstein, Mark
AU  - Bernstein M
FAU - Lozano, Andres M
AU  - Lozano AM
LA  - eng
PT  - Journal Article
DEP - 20110617
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Comprehension
MH  - *Deep Brain Stimulation
MH  - Depressive Disorder, Treatment-Resistant/surgery/therapy
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Mental Disorders/*surgery
MH  - Obsessive-Compulsive Disorder/surgery/therapy
MH  - Patient Selection
MH  - *Research Design
EDAT- 2011/06/21 06:00
MHDA- 2012/05/02 06:00
CRDT- 2011/06/21 06:00
PHST- 2011/06/21 06:00 [entrez]
PHST- 2011/06/21 06:00 [pubmed]
PHST- 2012/05/02 06:00 [medline]
AID - jme.2010.042002 [pii]
AID - 10.1136/jme.2010.042002 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Feb;38(2):107-11. doi: 10.1136/jme.2010.042002. Epub 2011 Jun 
      17.


PMID- 21685147
OWN - NLM
STAT- MEDLINE
DCOM- 20120322
LR  - 20211020
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 1
DP  - 2012 Jan
TI  - Abortion decisions as inclusion and exclusion criteria in research involving
      pregnant women and fetuses.
PG  - 43-7
LID - 10.1136/jme.2011.043661 [doi]
AB  - From the perspective of investigators conducting research involving pregnant
      women and fetuses, a woman's decision about whether to have an abortion can
      sometimes be relevant to the suitability of the woman and fetus as research
      subjects. However, prominent ethicists disagree over whether it is permissible
      for a woman's decision about abortion to be an inclusion or exclusion criterion
      for participation in research. A widely held view is that fetuses to be aborted
      and fetuses to be carried to term should be treated equally as research subjects.
      Some hold that this principle implies that a woman's decision about whether to
      have an abortion should not be an inclusion or exclusion criterion. This paper
      identifies types of research in which investigators might want to have inclusion 
      or exclusion criteria based on decisions about abortion. It examines the
      arguments for and against having the woman's decision about abortion included in 
      such criteria. It is argued that there are types of research in which such
      criteria are ethically permissible.
FAU - Strong, Carson
AU  - Strong C
AD  - Department of Medicine, University of Tennessee Health Science Center, 956 Court 
      Avenue, Memphis TN 38163, USA. cstrong@uthsc.edu
LA  - eng
GR  - R03 HG005225/HG/NHGRI NIH HHS/United States
GR  - R03 HG005225-01/HG/NHGRI NIH HHS/United States
GR  - R03 HG 005225/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110617
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Abortion, Induced
MH  - Abortion, Legal
MH  - Ethics, Medical
MH  - *Ethics, Research
MH  - Female
MH  - Fetus
MH  - Humans
MH  - Morals
MH  - Patient Selection/*ethics
MH  - Pregnancy
MH  - Pregnant Women
MH  - Women's Rights
PMC - PMC3241879
MID - NIHMS341596
EDAT- 2011/06/21 06:00
MHDA- 2012/03/23 06:00
CRDT- 2011/06/21 06:00
PHST- 2011/06/21 06:00 [entrez]
PHST- 2011/06/21 06:00 [pubmed]
PHST- 2012/03/23 06:00 [medline]
AID - jme.2011.043661 [pii]
AID - 10.1136/jme.2011.043661 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Jan;38(1):43-7. doi: 10.1136/jme.2011.043661. Epub 2011 Jun
      17.


PMID- 21685146
OWN - NLM
STAT- MEDLINE
DCOM- 20120224
LR  - 20110822
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 9
DP  - 2011 Sep
TI  - Mario Monicelli's Grande guerra: the right of living and the choice of dying.
PG  - 573-6
LID - 10.1136/jme.2011.042267 [doi]
AB  - Monicelli's suicide has reawakened a political and legal dispute about the
      medical role in end-of-life decisions, allowing us to discuss medical, ethical,
      legal, religious and political debate in various paradigmatic conscious and
      unconscious cases of end-of-life decision. We analyse the uncertainty about the
      'a priori' choice between different specific legislative systems, highlighting
      the need for a unifying model, dictated by the existing trust in the critical
      relationship between patient and doctor, whose primary mission should be not only
      'to cure' but also 'to care'.
FAU - Gulino, Matteo
AU  - Gulino M
AD  - Department of Anatomical, Histological, Forensic and Orthopaedic Sciences,
      Sapienza University of Rome, Rome, Italy.
FAU - Frati, Giacomo
AU  - Frati G
FAU - Vergallo, Gianluca Montanari
AU  - Vergallo GM
FAU - Frati, Paola
AU  - Frati P
LA  - eng
PT  - Journal Article
DEP - 20110617
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Advance Directives/legislation & jurisprudence
MH  - Ethics, Medical
MH  - Euthanasia/*ethics/*legislation & jurisprudence
MH  - Humans
MH  - Living Wills
MH  - Morals
MH  - Patient Rights/*ethics/*legislation & jurisprudence
MH  - Physician-Patient Relations/ethics
MH  - Politics
MH  - Suicide/ethics
MH  - Terminal Care/*ethics/legislation & jurisprudence
EDAT- 2011/06/21 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/06/21 06:00
PHST- 2011/06/21 06:00 [entrez]
PHST- 2011/06/21 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - jme.2011.042267 [pii]
AID - 10.1136/jme.2011.042267 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Sep;37(9):573-6. doi: 10.1136/jme.2011.042267. Epub 2011 Jun
      17.


PMID- 21684674
OWN - NLM
STAT- MEDLINE
DCOM- 20111202
LR  - 20220311
IS  - 1432-0436 (Electronic)
IS  - 0301-4681 (Linking)
VI  - 82
IP  - 2
DP  - 2011 Sep
TI  - Isolation and cellular properties of mesenchymal cells derived from the decidua
      of human term placenta.
PG  - 77-88
LID - 10.1016/j.diff.2011.05.010 [doi]
AB  - The clinical promise of cell-based therapies is generally recognized, and has
      driven an intense search for good cell sources. In this study, we isolated
      plastic-adherent cells from human term decidua vera, called
      decidua-derived-mesenchymal cells (DMCs), and compared their properties with
      those of bone marrow-derived-mesenchymal stem cells (BM-MSCs). The DMCs strongly 
      expressed the mesenchymal cell marker vimentin, but not cytokeratin 19 or HLA-G, 
      and had a high proliferative potential. That is, they exhibited a typical
      fibroblast-like morphology for over 30 population doublings. Cells phenotypically
      identical to the DMCs were identified in the decidua vera, and genotyping
      confirmed that the DMCs were derived from the maternal components of the fetal
      adnexa. Flow cytometry analysis showed that the expression pattern of CD antigens
      on the DMCs was almost identical to that on BM-MSCs, but some DMCs expressed the 
      CD45 antigen, and over 50% of them also expressed anti-fibroblast antigen. In
      vitro, the DMCs showed good differentiation into chondrocytes and moderate
      differentiation into adipocytes, but scant evidence of osteogenesis, compared
      with the BM-MSCs. Gene expression analysis showed that, compared with BM-MSCs,
      the DMCs expressed higher levels of TWIST2 and RUNX2 (which are associated with
      early mesenchymal development and/or proliferative capacity), several matrix
      metalloproteinases (MMP1, 3, 10, and 12), and cytokines (BMP2 and TGFB2), and
      lower levels of MSX2, interleukin 26, and HGF. Although DMCs did not show the
      full multipotency of BM-MSCs, their higher proliferative ability indicates that
      their cultivation would require less maintenance. Furthermore, the use of DMCs
      avoids the ethical concerns associated with the use of embryonic tissues, because
      they are derived from the maternal portion of the placenta, which is otherwise
      discarded. Thus, the unique properties of DMCs give them several advantages for
      clinical use, making them an interesting and attractive alternative to MSCs for
      regenerative medicine.
CI  - 2011 International Society of Differentiation. Published by Elsevier B.V. All
      rights reserved.
FAU - Kanematsu, Daisuke
AU  - Kanematsu D
AD  - Department of Regenerative Medicine, Institute for Clinical Research, Osaka
      National Hospital, National Hospital Organization, 2-1-14 Hoenzaka, Chuo-ku,
      Osaka 540-0006, Japan.
FAU - Shofuda, Tomoko
AU  - Shofuda T
FAU - Yamamoto, Atsuyo
AU  - Yamamoto A
FAU - Ban, Chiaki
AU  - Ban C
FAU - Ueda, Takafumi
AU  - Ueda T
FAU - Yamasaki, Mami
AU  - Yamasaki M
FAU - Kanemura, Yonehiro
AU  - Kanemura Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Differentiation
JT  - Differentiation; research in biological diversity
JID - 0401650
RN  - 0 (Core Binding Factor Alpha 1 Subunit)
RN  - 0 (Cytokines)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Keratin-19)
RN  - 0 (RUNX2 protein, human)
RN  - 0 (Repressor Proteins)
RN  - 0 (TWIST2 protein, human)
RN  - 0 (Twist-Related Protein 1)
RN  - 0 (Vimentin)
RN  - EC 3.1.3.48 (Leukocyte Common Antigens)
RN  - EC 3.4.- (Metalloproteases)
SB  - IM
MH  - Adipocytes/cytology
MH  - Adnexa Uteri/cytology
MH  - Bone Marrow Cells/cytology
MH  - Cell Differentiation
MH  - *Cell Separation
MH  - Chondrocytes/cytology
MH  - Core Binding Factor Alpha 1 Subunit/metabolism
MH  - Cytokines/metabolism
MH  - Decidua/*cytology
MH  - Female
MH  - HLA-G Antigens/metabolism
MH  - Humans
MH  - Keratin-19/metabolism
MH  - Leukocyte Common Antigens/metabolism
MH  - Mesenchymal Stem Cells/*cytology
MH  - Metalloproteases/metabolism
MH  - Microsatellite Repeats/genetics
MH  - Osteogenesis
MH  - Placenta/*cytology
MH  - Pregnancy
MH  - Repressor Proteins/metabolism
MH  - Twist-Related Protein 1/metabolism
MH  - Vimentin/metabolism
EDAT- 2011/06/21 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/06/21 06:00
PHST- 2010/08/25 00:00 [received]
PHST- 2011/05/06 00:00 [revised]
PHST- 2011/05/26 00:00 [accepted]
PHST- 2011/06/21 06:00 [entrez]
PHST- 2011/06/21 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0301-4681(11)00107-1 [pii]
AID - 10.1016/j.diff.2011.05.010 [doi]
PST - ppublish
SO  - Differentiation. 2011 Sep;82(2):77-88. doi: 10.1016/j.diff.2011.05.010.


PMID- 21683918
OWN - NLM
STAT- MEDLINE
DCOM- 20111118
LR  - 20211020
IS  - 1558-0490 (Electronic)
IS  - 1056-4993 (Linking)
VI  - 20
IP  - 3
DP  - 2011 Jul
TI  - On the use and misuse of genomic and neuroimaging science in forensic psychiatry:
      current roles and future directions.
PG  - 533-46
LID - 10.1016/j.chc.2011.03.012 [doi]
AB  - Dramatic advances in the understanding of the neurobiological bases of human
      behavior have prompted excitement and controversy surrounding the ethical, legal,
      and social applications of this knowledge. The authors critically examine the
      promise and challenges of integrating genomic and neuroimaging techniques into
      legal settings. They suggest criteria for enhancing the viability of
      incorporating these data within a legal context and highlight several recent
      developments that may eventually allow genetic and neuroimaging evidence to meet 
      these criteria and play a more prominent role in forensic science and law.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Treadway, Michael T
AU  - Treadway MT
AD  - Department of Psychology, Vanderbilt University, Nashville, TN 37203, USA.
      m.treadway@vanderbilt.edu
FAU - Buckholtz, Joshua W
AU  - Buckholtz JW
LA  - eng
GR  - F31 MH087015/MH/NIMH NIH HHS/United States
GR  - T32 MH018921/MH/NIMH NIH HHS/United States
GR  - F31MH087015/MH/NIMH NIH HHS/United States
GR  - T32MH018921/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Child Adolesc Psychiatr Clin N Am
JT  - Child and adolescent psychiatric clinics of North America
JID - 9313451
SB  - IM
MH  - Brain/*abnormalities/*pathology/physiopathology
MH  - DNA Fingerprinting/legislation & jurisprudence/*trends
MH  - *Diagnostic Imaging
MH  - Expert Testimony/legislation & jurisprudence
MH  - Forecasting
MH  - Forensic Psychiatry/*legislation & jurisprudence/*trends
MH  - Humans
MH  - Mental Competency/*legislation & jurisprudence
MH  - Mental Disorders/*diagnosis/*genetics/psychology
MH  - Predictive Value of Tests
MH  - United States
PMC - PMC5530871
MID - NIHMS881563
EDAT- 2011/06/21 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/06/21 06:00
PHST- 2011/06/21 06:00 [entrez]
PHST- 2011/06/21 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S1056-4993(11)00040-X [pii]
AID - 10.1016/j.chc.2011.03.012 [doi]
PST - ppublish
SO  - Child Adolesc Psychiatr Clin N Am. 2011 Jul;20(3):533-46. doi:
      10.1016/j.chc.2011.03.012.


PMID- 21683916
OWN - NLM
STAT- MEDLINE
DCOM- 20111118
LR  - 20110620
IS  - 1558-0490 (Electronic)
IS  - 1056-4993 (Linking)
VI  - 20
IP  - 3
DP  - 2011 Jul
TI  - Estimating present and future damages following child maltreatment.
PG  - 505-18
LID - 10.1016/j.chc.2011.03.005 [doi]
AB  - The child psychiatric forensic evaluation of children and adolescents who are
      plaintiffs in civil lawsuits regarding their present and future damages from
      child maltreatment requires knowledge of current research findings on the
      short-term and long-term consequences of child maltreatment, evidence-based
      treatments for psychological trauma, and relevant professional guidelines, along 
      with knowledge of the ethics and laws governing mental health expert practice and
      testimony in personal injury litigation. This article reviews current research
      and recommends an approach to these evaluations and expert testimony that is
      informed by current research findings, recently developed professional
      guidelines, and many years of professional experience.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Corwin, David L
AU  - Corwin DL
AD  - Pediatrics' Child Protection and Family Health Division, University of Utah
      School of Medicine, Salt Lake City, USA. david.corwin@imail.org
FAU - Keeshin, Brooks R
AU  - Keeshin BR
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110510
PL  - United States
TA  - Child Adolesc Psychiatr Clin N Am
JT  - Child and adolescent psychiatric clinics of North America
JID - 9313451
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Adult Children/*psychology
MH  - Battered Child Syndrome/*diagnosis/*psychology
MH  - Child
MH  - Child Abuse/diagnosis/*legislation & jurisprudence/*psychology
MH  - Child Abuse, Sexual/diagnosis/*legislation & jurisprudence/*psychology
MH  - Child of Impaired Parents/legislation & jurisprudence/psychology
MH  - Child, Preschool
MH  - Data Collection
MH  - Expert Testimony/legislation & jurisprudence
MH  - Female
MH  - Humans
MH  - Infant
MH  - Life Change Events
MH  - Longitudinal Studies
MH  - Male
MH  - Mentally Ill Persons/legislation & jurisprudence/psychology
MH  - Prognosis
MH  - Risk Assessment
MH  - Risk Factors
MH  - Statistics as Topic
MH  - Stress Disorders, Post-Traumatic/*diagnosis/*psychology
EDAT- 2011/06/21 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/06/21 06:00
PHST- 2011/06/21 06:00 [entrez]
PHST- 2011/06/21 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S1056-4993(11)00033-2 [pii]
AID - 10.1016/j.chc.2011.03.005 [doi]
PST - ppublish
SO  - Child Adolesc Psychiatr Clin N Am. 2011 Jul;20(3):505-18. doi:
      10.1016/j.chc.2011.03.005. Epub 2011 May 10.


PMID- 21683211
OWN - NLM
STAT- MEDLINE
DCOM- 20111031
LR  - 20131121
IS  - 1531-5037 (Electronic)
IS  - 0022-3468 (Linking)
VI  - 46
IP  - 6
DP  - 2011 Jun
TI  - Disaster response in a pediatric field hospital: lessons learned in Haiti.
PG  - 1131-9
LID - 10.1016/j.jpedsurg.2011.03.042 [doi]
AB  - PURPOSE: This study outlines the evolution of a pediatric field hospital after
      the January 2010 Haiti earthquake. METHODS: Project Medishare set up a field
      hospital in Port-au-Prince 48 hours after the event. Our institution staffed the 
      pediatric component for 45 days, with sequential deployment of 9 volunteer
      medical teams. Evolving facility and manpower requirements and changing patient
      demographics over time were evaluated. RESULTS: Delegations consisted of
      surgeons, pediatricians, nurses, operating room (OR) personnel, physical
      therapists, pharmacists, and support staff. Primary goals involved creation of a 
      child-specific ward, pediatric OR, and a wound care center. Major inpatient
      demographic changes occurred as time from the disaster elapsed. Initial census
      showed that 93% of the patients were surgical admissions with 40% undergoing
      operations, mostly fracture and wound care, over the first week. Eight weeks
      later, medical illnesses accounted for 70% of inpatients, whereas OR volume
      dropped by more than 50%. A second trend involved increasing acuity of care.
      Initially, children were admitted for serious or limb-threatening, but usually
      not life-threatening, injuries. Within 2 months, one third of the patients were
      housed in the developing NICU/PICU; and only 12% were admitted for injuries
      related to the earthquake. This change in patient needs led to alterations in
      facility requirements and in staffing and leadership needs. CONCLUSION: A
      disaster involving significant casualties in a populated area demands the rapid
      development of a field facility with pediatric personnel. Requirements for
      equipment, manpower, medical records, and systems addressing volunteer stress and
      ethical dilemmas can be anticipated.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Burnweit, Cathy
AU  - Burnweit C
AD  - Department of Pediatric Surgery, Miami Children's Hospital and FIU College of
      Medicine, Miami, FL 33155, USA. cburnweit@aol.com
FAU - Stylianos, Steven
AU  - Stylianos S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pediatr Surg
JT  - Journal of pediatric surgery
JID - 0052631
SB  - IM
MH  - Child
MH  - Disaster Medicine/organization & administration
MH  - Disaster Planning/*organization & administration
MH  - *Disasters
MH  - *Earthquakes
MH  - Female
MH  - Haiti
MH  - Hospitals, Pediatric/*organization & administration
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - International Cooperation
MH  - Male
MH  - Mobile Health Units
MH  - Multiple Trauma/diagnosis/mortality/surgery
MH  - Operating Rooms/organization & administration
MH  - Program Evaluation
MH  - Relief Work/organization & administration
MH  - Risk Assessment
MH  - Survival Rate
MH  - Time Factors
MH  - Volunteers/organization & administration
EDAT- 2011/06/21 06:00
MHDA- 2011/11/01 06:00
CRDT- 2011/06/21 06:00
PHST- 2011/03/08 00:00 [received]
PHST- 2011/03/26 00:00 [accepted]
PHST- 2011/06/21 06:00 [entrez]
PHST- 2011/06/21 06:00 [pubmed]
PHST- 2011/11/01 06:00 [medline]
AID - S0022-3468(11)00257-0 [pii]
AID - 10.1016/j.jpedsurg.2011.03.042 [doi]
PST - ppublish
SO  - J Pediatr Surg. 2011 Jun;46(6):1131-9. doi: 10.1016/j.jpedsurg.2011.03.042.


PMID- 21682936
OWN - NLM
STAT- MEDLINE
DCOM- 20111107
LR  - 20110722
IS  - 1435-8115 (Electronic)
IS  - 1431-9276 (Linking)
VI  - 17
IP  - 4
DP  - 2011 Aug
TI  - Pluripotent stem cells and reprogrammed cells in farm animals.
PG  - 474-97
LID - 10.1017/S1431927611000080 [doi]
AB  - Pluripotent cells are unique because of their ability to differentiate into the
      cell lineages forming the entire organism. True pluripotent stem cells with germ 
      line contribution have been reported for mice and rats. Human pluripotent cells
      share numerous features of pluripotentiality, but confirmation of their in vivo
      capacity for germ line contribution is impossible due to ethical and legal
      restrictions. Progress toward derivation of embryonic stem cells from domestic
      species has been made, but the derived cells were not able to produce germ line
      chimeras and thus are termed embryonic stem-like cells. However, domestic
      animals, in particular the domestic pig (Sus scrofa), are excellent large animals
      models, in which the clinical potential of stem cell therapies can be studied.
      Reprogramming technologies for somatic cells, including somatic cell nuclear
      transfer, cell fusion, in vitro culture in the presence of cell extracts, in
      vitro conversion of adult unipotent spermatogonial stem cells into germ line
      derived pluripotent stem cells, and transduction with reprogramming factors have 
      been developed with the goal of obtaining pluripotent, germ line competent stem
      cells from domestic animals. This review summarizes the present state of the art 
      in the derivation and maintenance of pluripotent stem cells in domestic animals.
FAU - Nowak-Imialek, Monika
AU  - Nowak-Imialek M
AD  - Institute of Farm Animal Genetics (FLI), Biotechnology, Mariensee, 31535
      Neustadt, Germany.
FAU - Kues, Wilfried
AU  - Kues W
FAU - Carnwath, Joseph W
AU  - Carnwath JW
FAU - Niemann, Heiner
AU  - Niemann H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110620
PL  - United States
TA  - Microsc Microanal
JT  - Microscopy and microanalysis : the official journal of Microscopy Society of
      America, Microbeam Analysis Society, Microscopical Society of Canada
JID - 9712707
SB  - IM
MH  - Animals
MH  - *Animals, Domestic
MH  - Biomedical Research/methods/trends
MH  - Mice
MH  - Pluripotent Stem Cells/*physiology
MH  - Rats
MH  - Stem Cell Transplantation/*methods
EDAT- 2011/06/21 06:00
MHDA- 2011/11/08 06:00
CRDT- 2011/06/21 06:00
PHST- 2011/06/21 06:00 [entrez]
PHST- 2011/06/21 06:00 [pubmed]
PHST- 2011/11/08 06:00 [medline]
AID - S1431927611000080 [pii]
AID - 10.1017/S1431927611000080 [doi]
PST - ppublish
SO  - Microsc Microanal. 2011 Aug;17(4):474-97. doi: 10.1017/S1431927611000080. Epub
      2011 Jun 20.


PMID- 21682908
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1756-0500 (Electronic)
IS  - 1756-0500 (Linking)
VI  - 4
DP  - 2011 Jun 18
TI  - Dealing with Alcohol-related problems in the Night-Time Economy: A Study Protocol
      for Mapping trends in harm and stakeholder views surrounding local community
      level interventions.
PG  - 204
LID - 10.1186/1756-0500-4-204 [doi]
AB  - BACKGROUND: This project will provide a comprehensive investigation into the
      prevalence of alcohol-related harms and community attitudes in the context of
      community-based interventions being implemented to reduce harm in two regional
      centres of Australia. While considerable experimentation and innovation to
      address these harms has occurred in both Geelong and Newcastle, only limited
      ad-hoc documentation and analysis has been conducted on changes in the prevalence
      of harm as a consequence, leaving a considerable gap in terms of a systematic,
      evidence-based analysis of changes in harm over time and the need for further
      intervention. Similarly, little evidence has been reported regarding the views of
      key stakeholder groups, industry, government agencies, patrons or community
      regarding the need for, and the acceptability of, interventions to reduce harms. 
      This project will aim to provide evidence regarding the impact and acceptability 
      of local initiatives aimed at reducing alcohol-related harms. METHODS/DESIGN:
      This study will gather existing police data (assault, property damage and drink
      driving offences), Emergency Department presentations and Ambulance attendance
      data. Further, the research team will conduct interviews with licensed venue
      patrons and collect observational data of licensed venues. Key informant
      interviews will assess expert knowledge from key industry and government
      stakeholders, and a community survey will assess community experiences and
      attitudes towards alcohol-related harm and harm-reduction strategies. Overall,
      the project will assess: the extent of alcohol-related harm in the context of
      harm-reduction interventions, and the need for and acceptability of further
      intervention. DISCUSSION: These findings will be used to improve evidence-based
      practice both nationally and internationally. ETHICAL APPROVAL: This project has 
      been approved by Deakin University HREC.
FAU - Miller, Peter
AU  - Miller P
AD  - School of Psychology, Deakin University, Geelong, Victoria, Australia.
      peter.miller@deakin.edu.au.
FAU - Palmer, Darren
AU  - Palmer D
FAU - Droste, Nicolas
AU  - Droste N
FAU - Tindall, Jenny
AU  - Tindall J
FAU - Gillham, Karen
AU  - Gillham K
FAU - Sonderlund, Anders
AU  - Sonderlund A
FAU - McFarlane, Emma
AU  - McFarlane E
FAU - de Groot, Florentine
AU  - de Groot F
FAU - Sawyer, Amy
AU  - Sawyer A
FAU - Groombridge, Daniel
AU  - Groombridge D
FAU - Lecathelinais, Christophe
AU  - Lecathelinais C
FAU - Wiggers, John
AU  - Wiggers J
LA  - eng
PT  - Journal Article
DEP - 20110618
PL  - England
TA  - BMC Res Notes
JT  - BMC research notes
JID - 101462768
PMC - PMC3141518
EDAT- 2011/06/21 06:00
MHDA- 2011/06/21 06:01
CRDT- 2011/06/21 06:00
PHST- 2011/05/24 00:00 [received]
PHST- 2011/06/18 00:00 [accepted]
PHST- 2011/06/21 06:00 [entrez]
PHST- 2011/06/21 06:00 [pubmed]
PHST- 2011/06/21 06:01 [medline]
AID - 1756-0500-4-204 [pii]
AID - 10.1186/1756-0500-4-204 [doi]
PST - epublish
SO  - BMC Res Notes. 2011 Jun 18;4:204. doi: 10.1186/1756-0500-4-204.


PMID- 21682858
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20220316
IS  - 1472-6920 (Electronic)
IS  - 1472-6920 (Linking)
VI  - 11
DP  - 2011 Jun 17
TI  - A comparison of online versus on-site training in health research methodology: a 
      randomized study.
PG  - 37
LID - 10.1186/1472-6920-11-37 [doi]
AB  - BACKGROUND: Distance learning may be useful for building health research
      capacity. However, evidence that it can improve knowledge and skills in health
      research, particularly in resource-poor settings, is limited. We compared the
      impact and acceptability of teaching two distinct content areas, Biostatistics
      and Research Ethics, through either on-line distance learning format or
      traditional on-site training, in a randomized study in India. Our objective was
      to determine whether on-line courses in Biostatistics and Research Ethics could
      achieve similar improvements in knowledge, as traditional on-site,
      classroom-based courses. METHODS: SUBJECTS: Volunteer Indian scientists were
      randomly assigned to one of two arms. INTERVENTION: Students in Arm 1 attended a 
      3.5-day on-site course in Biostatistics and completed a 3.5-week on-line course
      in Research Ethics. Students in Arm 2 attended a 3.5-week on-line course in
      Biostatistics and 3.5-day on-site course in Research Ethics. For the two course
      formats, learning objectives, course contents and knowledge tests were identical.
      MAIN OUTCOME MEASURES: Improvement in knowledge immediately and 3-months after
      course completion, compared to baseline. RESULTS: Baseline characteristics were
      similar in both arms (n = 29 each). Median knowledge score for Biostatistics
      increased from a baseline of 49% to 64% (p < 0.001) 3 months after the on-site
      course, and from 48% to 63% (p = 0.009) after the on-line course. For the on-site
      Research Ethics course, median score increased from 69% to 83% (p = 0.005), and
      for the on-line Research Ethics course from 62% to 80% (p < 0.001). Three months 
      after the course, median gains in knowledge scores remained similar for the
      on-site and on-line platforms for both Biostatistics (16% vs. 12%; p = 0.59) and 
      Research Ethics (17% vs. 13%; p = 0.14). CONCLUSION: On-line and on-site training
      formats led to marked and similar improvements of knowledge in Biostatistics and 
      Research Ethics. This, combined with logistical and cost advantages of on-line
      training, may make on-line courses particularly useful for expanding health
      research capacity in resource-limited settings.
FAU - Aggarwal, Rakesh
AU  - Aggarwal R
AD  - Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India. 
      aggarwal.ra@gmail.com
FAU - Gupte, Nikhil
AU  - Gupte N
FAU - Kass, Nancy
AU  - Kass N
FAU - Taylor, Holly
AU  - Taylor H
FAU - Ali, Joseph
AU  - Ali J
FAU - Bhan, Anant
AU  - Bhan A
FAU - Aggarwal, Amita
AU  - Aggarwal A
FAU - Sisson, Stephen D
AU  - Sisson SD
FAU - Kanchanaraksa, Sukon
AU  - Kanchanaraksa S
FAU - McKenzie-White, Jane
AU  - McKenzie-White J
FAU - McGready, John
AU  - McGready J
FAU - Miotti, Paolo
AU  - Miotti P
FAU - Bollinger, Robert C
AU  - Bollinger RC
LA  - eng
GR  - #2D43 TW000010-22-AITRP/TW/FIC NIH HHS/United States
GR  - AIU01069497/PHS HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
DEP - 20110617
PL  - England
TA  - BMC Med Educ
JT  - BMC medical education
JID - 101088679
SB  - IM
MH  - Adult
MH  - *Education, Distance
MH  - Female
MH  - Humans
MH  - India
MH  - *Internet
MH  - Male
MH  - Middle Aged
MH  - *Research Design
MH  - Research Personnel/*education
MH  - Teaching/*methods
PMC - PMC3141795
EDAT- 2011/06/21 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/06/21 06:00
PHST- 2010/11/26 00:00 [received]
PHST- 2011/06/17 00:00 [accepted]
PHST- 2011/06/21 06:00 [entrez]
PHST- 2011/06/21 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 1472-6920-11-37 [pii]
AID - 10.1186/1472-6920-11-37 [doi]
PST - epublish
SO  - BMC Med Educ. 2011 Jun 17;11:37. doi: 10.1186/1472-6920-11-37.


PMID- 21682677
OWN - NLM
STAT- MEDLINE
DCOM- 20120404
LR  - 20191112
IS  - 1876-1038 (Electronic)
IS  - 1574-8871 (Linking)
VI  - 6
IP  - 3
DP  - 2011 Sep
TI  - Clinical trials using vasodilators in pulmonary arterial hypertension: where do
      we go from here?
PG  - 228-34
AB  - BACKGROUND: The impact of treatment with vasodilators on the survival of patients
      with pulmonary arterial hypertension (PAH) remains uncertain. Despite several
      clinical trials have been carried out in the last 15 years, their primary
      objective was not to assess mortality but the changes on surrogate end points.
      METHODS AND RESULTS: We reviewed the results of all clinical trials with
      vasodilators in PAH and the main results of different metaanalysis. Clinical
      trials and systematic reviews confirm that vasodilator therapies in patients with
      PAH who are non-vasoreactive produce a consistent, statistically significant but 
      a marginal effect on exercise capacity assessed by the six-minute walk test. The 
      weighted mean difference (95% CI) achieved with epoprostenol (EPO) or other
      prostacyclin analogues (PCA), endothelin receptor antagonists (ETRA) and
      phosphodiesterase-type-5 inhibitors (PDE5-I) was 35.4 m (17.3-53.5), 46.1 m
      (38.1-54.2) and 33.8 m (24.8-42.7), respectively. When considering the cumulative
      effects within each drug family, no class of drug produced a statistically
      significant reduction in all cause mortality. The relative risk rates (95% CI)
      conferred by EPO or PCA, ETRA and PDE5-I were 0.66 (0.36-1.21), 0.48 (0.19-1.23) 
      and 0.65 (0.16-2.67), respectively. INTERPRETATION: Further trials utilizing
      similar classes of drugs, and following similar trial designs are unlikely to
      yield different results or offer any more clinical benefits. Given that PAH is a 
      fatal disease this raises concerns about whether they are ethical to conduct or
      not. Future trials will need to utilize clinical endpoints rather than the ones
      that are easy to administer and will need to include longer durations of study
      and other strategies to test the durability of effect.
FAU - Macchia, Alejandro
AU  - Macchia A
AD  - Epidemiology Section - CEMIC (Centro de Educacion Medica e Investigaciones
      Clinicas), Buenos Aires, Argentina. macchia@negrisud.it
FAU - Mariani, Javier
AU  - Mariani J
FAU - Comignani, Pablo Dino
AU  - Comignani PD
FAU - Tognoni, Gianni
AU  - Tognoni G
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Rev Recent Clin Trials
JT  - Reviews on recent clinical trials
JID - 101270873
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Endothelin Receptor Antagonists)
RN  - 0 (Phosphodiesterase Inhibitors)
RN  - 0 (Vasodilator Agents)
RN  - DCR9Z582X0 (Epoprostenol)
SB  - IM
MH  - Antihypertensive Agents/therapeutic use
MH  - Endothelin Receptor Antagonists
MH  - Epoprostenol/therapeutic use
MH  - Exercise Test
MH  - Exercise Tolerance/drug effects
MH  - Hemodynamics
MH  - Humans
MH  - Hypertension, Pulmonary/*drug therapy
MH  - Meta-Analysis as Topic
MH  - Phosphodiesterase Inhibitors/therapeutic use
MH  - Randomized Controlled Trials as Topic
MH  - Review Literature as Topic
MH  - Vasodilator Agents/*therapeutic use
EDAT- 2011/06/21 06:00
MHDA- 2012/04/05 06:00
CRDT- 2011/06/21 06:00
PHST- 2010/02/06 00:00 [received]
PHST- 2011/01/06 00:00 [revised]
PHST- 2011/01/08 00:00 [accepted]
PHST- 2011/06/21 06:00 [entrez]
PHST- 2011/06/21 06:00 [pubmed]
PHST- 2012/04/05 06:00 [medline]
AID - RRCT 0035aa [pii]
AID - 10.2174/157488711796575504 [doi]
PST - ppublish
SO  - Rev Recent Clin Trials. 2011 Sep;6(3):228-34. doi: 10.2174/157488711796575504.


PMID- 21682626
OWN - NLM
STAT- MEDLINE
DCOM- 20111102
LR  - 20220410
IS  - 1440-1665 (Electronic)
IS  - 1039-8562 (Linking)
VI  - 19
IP  - 3
DP  - 2011 Jun
TI  - Acceptability of Internet treatment of anxiety and depression.
PG  - 259-64
LID - 10.3109/10398562.2011.562295 [doi]
AB  - OBJECTIVE: The Internet is increasingly used to deliver treatment programs for
      common mental disorders. However, little is known about the acceptability of
      online interventions. The present study used an online survey to explore levels
      of acceptability of Internet-based treatment programs for anxiety and depression.
      METHODS: Visitors to websites operated by the Clinical Research Unit for Anxiety 
      and Depression (CRUfAD), were invited to complete an online questionnaire during 
      16 weeks in 2008. RESULTS: Of 1543 people who began the survey, 1104 (72%)
      Australian health professionals and lay people completed it. Internet treatment
      programs for people with mild or moderate symptoms were more acceptable than
      programs for people with severe symptoms. There were no differences between
      health professionals and non-health professionals in acceptability ratings. As
      expected, previous users of Internet treatments reported significantly greater
      acceptability and preference for Internet treatments than non-users. CONCLUSIONS:
      Respondents rated Internet-based treatment programs as acceptable, with higher
      ratings from previous users. In order to facilitate implementation, program
      developers need to implement strategies for increasing knowledge about the
      efficacy and effectiveness of such programs, and engage therapists and consumers 
      in establishing ethical and professional guidelines for their safe and
      responsible use.
FAU - Gun, Shih Ying
AU  - Gun SY
AD  - Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
FAU - Titov, Nickolai
AU  - Titov N
FAU - Andrews, Gavin
AU  - Andrews G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Australas Psychiatry
JT  - Australasian psychiatry : bulletin of Royal Australian and New Zealand College of
      Psychiatrists
JID - 9613603
SB  - IM
MH  - Adult
MH  - Anxiety/*therapy
MH  - Attitude of Health Personnel
MH  - Depression/*therapy
MH  - Female
MH  - Health Care Surveys/statistics & numerical data
MH  - Humans
MH  - *Internet
MH  - Male
MH  - Patient Acceptance of Health Care/*statistics & numerical data
MH  - Therapy, Computer-Assisted/methods/*statistics & numerical data
EDAT- 2011/06/21 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/06/21 06:00
PHST- 2011/06/21 06:00 [entrez]
PHST- 2011/06/21 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
AID - 10.3109/10398562.2011.562295 [doi]
PST - ppublish
SO  - Australas Psychiatry. 2011 Jun;19(3):259-64. doi: 10.3109/10398562.2011.562295.


PMID- 21682180
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20190923
IS  - 1547-1896 (Print)
IS  - 0893-7400 (Linking)
VI  - 24
IP  - 6
DP  - 2011 Jun
TI  - Is it better to give, receive, or decline? The ethics of accepting gifts from
      patients.
PG  - 59-60
FAU - Anderson, Jim
AU  - Anderson J
AD  - University of Washington Medicine-IT Services, Seattle, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - JAAPA
JT  - JAAPA : official journal of the American Academy of Physician Assistants
JID - 9513102
MH  - Conflict of Interest
MH  - Gift Giving/*ethics
MH  - Humans
MH  - *Professional-Patient Relations
EDAT- 2011/06/21 06:00
MHDA- 2011/07/27 06:00
CRDT- 2011/06/21 06:00
PHST- 2011/06/21 06:00 [entrez]
PHST- 2011/06/21 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
AID - 10.1097/01720610-201106000-00013 [doi]
PST - ppublish
SO  - JAAPA. 2011 Jun;24(6):59-60. doi: 10.1097/01720610-201106000-00013.


PMID- 21681692
OWN - NLM
STAT- MEDLINE
DCOM- 20120716
LR  - 20151119
IS  - 1573-2800 (Electronic)
IS  - 0004-0002 (Linking)
VI  - 41
IP  - 2
DP  - 2012 Apr
TI  - Doing more good than harm? The effects of participation in sex research on young 
      people in the Netherlands.
PG  - 497-506
LID - 10.1007/s10508-011-9780-y [doi]
AB  - Ethical guidelines for research with human participants stress the importance of 
      minimizing risks and maximizing benefits. In order to assist Institutional Review
      Boards (IRBs) and researchers to make more informed risk/benefit analyses with
      regard to sex research among adolescents, the current study examined the effects 
      of participation in sex research among 899 young people (15-25 years old).
      Participants completed three questionnaires on a wide range of sexuality-related 
      measures. They also completed scales measuring their levels of distress, need for
      help, and positive feelings due to their research participation. In general,
      negative effects of research participation seemed limited, while benefits of
      participation appeared substantial. Several differences with regard to
      sociodemographic characteristics were found (e.g., females experienced more
      distress then males and younger or lower educated participants experienced more
      positive feelings). In addition, victims of sexual coercion reported more
      distress and need for help due to their participation, but also experienced more 
      positive feelings. No significant differences were found in relation to
      experience with sexual risk behaviors (e.g., experience with one-night-stands).
      Several limitations of the study were discussed, as were implications for future 
      research. Overall, the findings caution IRBs and researchers against being overly
      protective regarding the inclusion of young people in sex research.
FAU - Kuyper, Lisette
AU  - Kuyper L
AD  - Rutgers Nisso Groep, P.O. Box 9022, 3506 GA, Utrecht, The Netherlands.
      l.kuyper@rng.nl
FAU - de Wit, John
AU  - de Wit J
FAU - Adam, Philippe
AU  - Adam P
FAU - Woertman, Liesbeth
AU  - Woertman L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110617
PL  - United States
TA  - Arch Sex Behav
JT  - Archives of sexual behavior
JID - 1273516
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Education
MH  - Emotions
MH  - Female
MH  - Humans
MH  - Male
MH  - Netherlands
MH  - *Research
MH  - Research Subjects/*psychology
MH  - Sex Factors
MH  - Sexual Behavior/*psychology
MH  - Stress, Psychological/*psychology
MH  - Surveys and Questionnaires
EDAT- 2011/06/18 06:00
MHDA- 2012/07/17 06:00
CRDT- 2011/06/18 06:00
PHST- 2010/05/13 00:00 [received]
PHST- 2011/04/21 00:00 [accepted]
PHST- 2011/04/16 00:00 [revised]
PHST- 2011/06/18 06:00 [entrez]
PHST- 2011/06/18 06:00 [pubmed]
PHST- 2012/07/17 06:00 [medline]
AID - 10.1007/s10508-011-9780-y [doi]
PST - ppublish
SO  - Arch Sex Behav. 2012 Apr;41(2):497-506. doi: 10.1007/s10508-011-9780-y. Epub 2011
      Jun 17.


PMID- 21680981
OWN - NLM
STAT- MEDLINE
DCOM- 20120103
LR  - 20110617
IS  - 1556-2654 (Electronic)
IS  - 1556-2646 (Linking)
VI  - 6
IP  - 2
DP  - 2011 Jun
TI  - Educational advantage.
PG  - 95
LID - 10.1525/jer.2011.6.2.95 [doi]
AB  - This issue of JERHRE examines topics relevant to a variety of issues connected
      with community-engaged research and the relationship of communities with research
      ethics committees (RECs). It also examines some of the ways in which risk is
      assessed by subject populations and by RECs. Educational activities are presented
      that will enable readers to more comprehensively assess the way RECs and
      communities can work together more easily and effectively, and that will enable
      RECs to better understand their own functioning, and that of subject populations 
      as these respective groups assess risk. The following assignments are best
      conducted in small groups.
LA  - eng
PT  - Introductory Journal Article
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Community-Based Participatory Research/*ethics
MH  - *Cooperative Behavior
MH  - *Ethics Committees, Research
MH  - Ethics, Research/*education
MH  - Humans
MH  - *Research Subjects
MH  - Risk Assessment/ethics
EDAT- 2011/06/18 06:00
MHDA- 2012/01/04 06:00
CRDT- 2011/06/18 06:00
PHST- 2011/06/18 06:00 [entrez]
PHST- 2011/06/18 06:00 [pubmed]
PHST- 2012/01/04 06:00 [medline]
AID - 10.1525/jer.2011.6.2.95 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2011 Jun;6(2):95. doi: 10.1525/jer.2011.6.2.95.


PMID- 21680979
OWN - NLM
STAT- MEDLINE
DCOM- 20120103
LR  - 20110617
IS  - 1556-2654 (Electronic)
IS  - 1556-2646 (Linking)
VI  - 6
IP  - 2
DP  - 2011 Jun
TI  - Ethnographic study of alternative sports by alternative means: list mining as a
      method of data collection.
PG  - 85-91
LID - 10.1525/jer.2011.6.2.85 [doi]
AB  - Increased usage and accessibility of the Internet has led to the rapid growth of 
      cyber communities; typical of groups that have embraced this idea are those who
      participate in what have been termed alternative or lifestyle sports. Thus far,
      this online world has received little attention from ethnographers, but the
      potential for obtaining rich data in this area is huge, most notably through the 
      practice of researching messages sent to Internet-based forums, known as list
      mining. The inclusion of list mining as a research method, however, is not
      without its problems and raises new ethical issues when conducting qualitative
      research. This paper examines in detail the ethical considerations concerning the
      use of list mining as a method of data collection within the alternative sporting
      subculture of Ultimate Frisbee.
FAU - Griggs, Gerald
AU  - Griggs G
AD  - Department of Physical Education and Sports Studies, School of Sport, Performing 
      ARts & Leisure, University of Wolverhampton, Walsall, UK. G.Griggs@wlv.ac.uk
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Anthropology, Cultural/*ethics/methods
MH  - Data Collection/*ethics/methods
MH  - Data Mining/*ethics
MH  - *Ethics, Research
MH  - Humans
MH  - Internet/*ethics
MH  - Qualitative Research
MH  - *Sports
EDAT- 2011/06/18 06:00
MHDA- 2012/01/04 06:00
CRDT- 2011/06/18 06:00
PHST- 2011/06/18 06:00 [entrez]
PHST- 2011/06/18 06:00 [pubmed]
PHST- 2012/01/04 06:00 [medline]
AID - 10.1525/jer.2011.6.2.85 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2011 Jun;6(2):85-91. doi: 10.1525/jer.2011.6.2.85.


PMID- 21680978
OWN - NLM
STAT- MEDLINE
DCOM- 20120103
LR  - 20110617
IS  - 1556-2654 (Electronic)
IS  - 1556-2646 (Linking)
VI  - 6
IP  - 2
DP  - 2011 Jun
TI  - Computer science security research and human subjects: emerging considerations
      for research ethics boards.
PG  - 71-83
LID - 10.1525/jer.2011.6.2.71 [doi]
AB  - This paper explores the growing concerns with computer science research, and in
      particular, computer security research and its relationship with the committees
      that review human subjects research. It offers cases that review boards are
      likely to confront, and provides a context for appropriate consideration of such 
      research, as issues of bots, clouds, and worms enter the discourse of human
      subjects review.
FAU - Buchanan, Elizabeth
AU  - Buchanan E
AD  - Center for Applied Ethics, University of Wisconsin-Stout, Menomonie, WI 54751,
      USA. buchanane@uwstout.edu
FAU - Aycock, John
AU  - Aycock J
FAU - Dexter, Scott
AU  - Dexter S
FAU - Dittrich, David
AU  - Dittrich D
FAU - Hvizdak, Erin
AU  - Hvizdak E
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Computer Security/*ethics
MH  - *Ethics Committees, Research
MH  - *Ethics, Research
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - *Research Subjects
EDAT- 2011/06/18 06:00
MHDA- 2012/01/04 06:00
CRDT- 2011/06/18 06:00
PHST- 2011/06/18 06:00 [entrez]
PHST- 2011/06/18 06:00 [pubmed]
PHST- 2012/01/04 06:00 [medline]
AID - 10.1525/jer.2011.6.2.71 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2011 Jun;6(2):71-83. doi: 10.1525/jer.2011.6.2.71.


PMID- 21680975
OWN - NLM
STAT- MEDLINE
DCOM- 20120103
LR  - 20110617
IS  - 1556-2654 (Electronic)
IS  - 1556-2646 (Linking)
VI  - 6
IP  - 2
DP  - 2011 Jun
TI  - How do IRB members make decisions? A review and research agenda.
PG  - 31-46
LID - 10.1525/jer.2011.6.2.31 [doi]
AB  - Many factors have been found to influence the nature and quality of the human
      research ethics review process. These are reviewed along with discussion of ways 
      in which normal psychological characteristics and group decision-making processes
      may affect the decisions of institutional review board (IRB) members when
      reviewing proposed research activities, and may contribute to the acknowledged
      variability of IRB responses to identical research proposals. Three salient
      features of human judgment and decision-making illuminated by the existing
      psychological research literature are used to illustrate this idea: Research
      findings related to (a) risk perception and acceptance, (b) the standards people 
      use to make decisions, and (c) some nonrational influences on group
      decision-making suggest how psychological characteristics may affect some
      outcomes of convened IRB meetings. Recognizing such influences may enable the
      improvement of IRB decision-making.
FAU - Pritchard, Ivor A
AU  - Pritchard IA
AD  - U.S. Department of Health and Human Services, Office for Human Research
      Protections, Rockville, MD 20852, USA. Ivor.Pritchard@hhs.gov
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Decision Making/*ethics
MH  - *Ethics Committees, Research
MH  - *Ethics, Research
MH  - Humans
MH  - Judgment/*ethics
MH  - Risk
MH  - Social Values
EDAT- 2011/06/18 06:00
MHDA- 2012/01/04 06:00
CRDT- 2011/06/18 06:00
PHST- 2011/06/18 06:00 [entrez]
PHST- 2011/06/18 06:00 [pubmed]
PHST- 2012/01/04 06:00 [medline]
AID - 10.1525/jer.2011.6.2.31 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2011 Jun;6(2):31-46. doi: 10.1525/jer.2011.6.2.31.


PMID- 21680974
OWN - NLM
STAT- MEDLINE
DCOM- 20120103
LR  - 20211020
IS  - 1556-2654 (Electronic)
IS  - 1556-2646 (Linking)
VI  - 6
IP  - 2
DP  - 2011 Jun
TI  - Developing community partner training: regulations and relationships.
PG  - 23-30
LID - 10.1525/jer.2011.6.2.23 [doi]
AB  - While funders increasingly support research that partners with communities,
      community partners still must submit to a regulatory oversight structure that
      does not reflect their unique research ethics challenges and needs. In
      recognition of the importance of collaborative research endeavors, the authors
      engaged in a process of reconnaissance and negotiations with local community
      partners and research ethics boards (REBs) at the University of Michigan to begin
      to address the mismatch between regulatory demands and community-based research
      realities. This preliminary process yielded both changes in the REB oversight
      structure and training required of community partnered research. While the
      ultimate impact of these changes remains to be seen, the process itself yielded
      insights and materials of use to both our local REBs, and hopefully those at
      other institutions as well. This article will present those insights and provide 
      links to those materials.
FAU - Solomon, Stephanie
AU  - Solomon S
AD  - Albert Gnaegi Center for Health Care Ethics, Saint Louis University, St Louis, MO
      63104-1314, USA. stesolom@gmail.com
FAU - Piechowski, Patricia J
AU  - Piechowski PJ
LA  - eng
GR  - UL1 RR024986/RR/NCRR NIH HHS/United States
GR  - UL1 RR024986-05/RR/NCRR NIH HHS/United States
GR  - 1R01NR009879/NR/NINR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Community-Based Participatory Research/*ethics/legislation & jurisprudence
MH  - *Cooperative Behavior
MH  - *Ethics Committees, Research
MH  - Ethics, Research/*education
MH  - Government Regulation
MH  - Humans
MH  - Michigan
MH  - *Social Control, Formal
MH  - United States
MH  - Universities
PMC - PMC3319414
MID - NIHMS357879
EDAT- 2011/06/18 06:00
MHDA- 2012/01/04 06:00
CRDT- 2011/06/18 06:00
PHST- 2011/06/18 06:00 [entrez]
PHST- 2011/06/18 06:00 [pubmed]
PHST- 2012/01/04 06:00 [medline]
AID - 10.1525/jer.2011.6.2.23 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2011 Jun;6(2):23-30. doi: 10.1525/jer.2011.6.2.23.


PMID- 21680973
OWN - NLM
STAT- MEDLINE
DCOM- 20120103
LR  - 20110617
IS  - 1556-2654 (Electronic)
IS  - 1556-2646 (Linking)
VI  - 6
IP  - 2
DP  - 2011 Jun
TI  - Relationships between community-based processes for research ethics review and
      institution-based IRBs: a national study.
PG  - 13-21
LID - 10.1525/jer.2011.6.2.13 [doi]
AB  - Community groups are implementing research ethics review processes to determine
      whether and how research is conducted in their communities. We report on a survey
      of 109 of these community-based review processes about their relationships with
      institution based research ethics boards (I-REBs). Ninety-two percent reported
      that studies they review were also reviewed by an I-REB. Over half characterized 
      their relationship with I-REBs positively. Those with positive relationships were
      significantly more likely to communicate with the involved I-REBs. Challenges
      when working with I-REBs included delays, communication problems, and lack of
      I-REB understanding of community-based participatory research. Strengthening
      relationships between community-based review processes and I-REBs could
      ultimately enhance reviews of community-engaged research.
FAU - Shore, Nancy
AU  - Shore N
AD  - University of New England School of Social Work, Portland, ME 04103, USA.
      nshore@une.edu
FAU - Drew, Elaine
AU  - Drew E
FAU - Brazauskas, Ruta
AU  - Brazauskas R
FAU - Seifer, Sarena D
AU  - Seifer SD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Community-Based Participatory Research/*ethics
MH  - Data Collection
MH  - *Ethics Committees, Research
MH  - *Ethics, Research
MH  - *Evaluation Studies as Topic
MH  - Humans
MH  - Interviews as Topic
MH  - *Organizations
EDAT- 2011/06/18 06:00
MHDA- 2012/01/04 06:00
CRDT- 2011/06/18 06:00
PHST- 2011/06/18 06:00 [entrez]
PHST- 2011/06/18 06:00 [pubmed]
PHST- 2012/01/04 06:00 [medline]
AID - 10.1525/jer.2011.6.2.13 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2011 Jun;6(2):13-21. doi: 10.1525/jer.2011.6.2.13.


PMID- 21680972
OWN - NLM
STAT- MEDLINE
DCOM- 20120103
LR  - 20211020
IS  - 1556-2654 (Electronic)
IS  - 1556-2646 (Linking)
VI  - 6
IP  - 2
DP  - 2011 Jun
TI  - Misbehaviors of front-line research personnel and the integrity of
      community-based research.
PG  - 3-12
LID - 10.1525/jer.2011.6.2.3 [doi]
AB  - There has been little empirical research into misconduct and misbehavior among
      community research workers who recruit and collect data in vulnerable and
      marginalized health populations and are also members of those same communities.
      We conducted qualitative interviews with community research workers and
      traditional research assistants to understand the context and consequences of
      misbehaviors that pose a threat to research ethics and data integrity. In our
      sample, more community research workers acknowledged engaging in research
      wrongdoing than did traditional research assistants. These behaviors were most
      prevalent among community research workers who were not well-integrated into the 
      research team. We suggest best practices for investigators to promote an
      environment that supports research integrity in research projects that employ
      community research workers.
FAU - True, Gala
AU  - True G
AD  - Center for Health Equity Research and Promotion, Philadelphia Veterans Affairs
      Medical Center, Philadelphia, PA 19104, USA. Jennifer.True2@va.gov
FAU - Alexander, Leslie B
AU  - Alexander LB
FAU - Richman, Kenneth A
AU  - Richman KA
LA  - eng
GR  - R01 NR009879/NR/NINR NIH HHS/United States
GR  - R01 NR009879-01/NR/NINR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Community-Based Participatory Research/*ethics
MH  - *Ethics, Research
MH  - Health
MH  - Humans
MH  - Interviews as Topic
MH  - Qualitative Research
MH  - Research Personnel/*ethics
MH  - Self Disclosure
MH  - *Vulnerable Populations
PMC - PMC3299002
MID - NIHMS357878
EDAT- 2011/06/18 06:00
MHDA- 2012/01/04 06:00
CRDT- 2011/06/18 06:00
PHST- 2011/06/18 06:00 [entrez]
PHST- 2011/06/18 06:00 [pubmed]
PHST- 2012/01/04 06:00 [medline]
AID - 10.1525/jer.2011.6.2.3 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2011 Jun;6(2):3-12. doi: 10.1525/jer.2011.6.2.3.


PMID- 21680304
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20211020
IS  - 1699-3055 (Electronic)
IS  - 1699-048X (Linking)
VI  - 13
IP  - 6
DP  - 2011 Jun
TI  - Limited impact of palliative chemotherapy on survival in advanced solid tumours
      in patients with poor performance status.
PG  - 426-9
LID - 10.1007/s12094-011-0677-y [doi]
AB  - AIM: Oncologists should carefully weigh up the risks and benefits of palliative
      chemotherapy in patients with advanced solid tumours (AST) and poor general
      status from the standpoint both of medical and ethical issues and of healthcare
      resources required. This study is intended to assess the impact on overall
      survival of palliative chemotherapy in patients with AST and admitted to hospital
      as a result of their poor ECOG status. MATERIALS AND METHODS: We performed a
      retrospective analysis of 92 hospitalised patients with AST, ECOG 3-4, who were
      treated with palliative chemotherapy. Uni- and multivariate statistical analyses 
      were conducted to determine the impact of clinical and disease variables (number 
      of previous chemotherapy lines, presence of comorbidities, presentation of
      anorexia-cachexia syndrome, delirium, dyspnoea, ascitis, brain metastases, T-cell
      count, albumin, haemoglobin and LDH) on survival in this patient population.
      RESULTS: Mean age was 54 years (range 15-80). No chemotherapy had been given for 
      advanced disease in 74%, 13% had received one line, 6% 2 lines and 7% >/=3 lines.
      Median survival, i.e., after initiation of chemotherapy to death, in these
      patients was 33 days (range 1-1390). The median of chemotherapy cycles was 1. In 
      the multivariate analysis, no previous chemotherapy, and absence of
      anorexia-cachexia syndrome and of comorbidities was associated with significantly
      improved survival in patients. Forty-nine percent of patients died within 30 days
      of therapy, 28% died between days 30 and 90, and only 23% of patients lived
      longer than 90 days. Grade 3-4 toxicities mainly entailed blood disorders, namely
      anaemia 8%, neutropenia 13% and thrombocytopenia 8%. Six patients (5%) developed 
      sepsis after therapy; of these, 3 died from this toxicity, 1 patient suffered
      cardiac toxicity, one patient leukoencephalopathy and 1 patient acute pulmonary
      thromboembolism. CONCLUSION: Palliative chemotherapy given to patients with AST
      and ECOG 3-4 with short life expectancy provided no benefit for survival. As a
      result, we may be over-treating these patients and contributing to poor-quality
      care.
FAU - Sanchez-Munoz, Alfonso
AU  - Sanchez-Munoz A
AD  - Medical Oncology Department, Hospital Universitario Virgen de la Victoria,
      Malaga, Spain. asmoncomed@yahoo.es
FAU - Perez-Ruiz, Elisabeth
AU  - Perez-Ruiz E
FAU - Saez, Maria Isabel
AU  - Saez MI
FAU - Trigo, Jose Manuel
AU  - Trigo JM
FAU - Galindo, M Mar
AU  - Galindo MM
FAU - Manzaneque, Lourdes
AU  - Manzaneque L
FAU - Jimenez, Begona
AU  - Jimenez B
FAU - Muros, Begona
AU  - Muros B
FAU - Alba, Emilio
AU  - Alba E
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Clin Transl Oncol
JT  - Clinical & translational oncology : official publication of the Federation of
      Spanish Oncology Societies and of the National Cancer Institute of Mexico
JID - 101247119
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
MH  - Female
MH  - Follow-Up Studies
MH  - *Health Status Indicators
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/*drug therapy/*mortality
MH  - *Palliative Care
MH  - Retrospective Studies
MH  - Survival Rate
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2011/06/18 06:00
MHDA- 2011/10/25 06:00
CRDT- 2011/06/18 06:00
PHST- 2011/06/18 06:00 [entrez]
PHST- 2011/06/18 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
AID - CLAT460 [pii]
AID - 10.1007/s12094-011-0677-y [doi]
PST - ppublish
SO  - Clin Transl Oncol. 2011 Jun;13(6):426-9. doi: 10.1007/s12094-011-0677-y.


PMID- 21680299
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20211020
IS  - 1699-3055 (Electronic)
IS  - 1699-048X (Linking)
VI  - 13
IP  - 6
DP  - 2011 Jun
TI  - The white book of radiation oncology in Spain.
PG  - 385-95
AB  - The White Book of Radiation Oncology provides a comprehensive overview of the
      current state of the speciality of radiation oncology in Spain and is intended to
      be used as a reference for physicians, health care administrators and hospital
      managers. The present paper summarises the most relevant aspects of the book's 13
      chapters in order to bring the message to a wider audience. Among the topics
      discussed are the epidemiology of cancer in Spain, the role of the radiation
      oncologist in cancer care, human and material resource needs, new technologies,
      training of specialists, clinical and cost management, clinical practice, quality
      control, radiological protection, ethics, relevant legislation, research &
      development, the history of radiation oncology in Spain and the origins of the
      Spanish Society of Radiation Oncology (SEOR).
FAU - Herruzo, Ismael
AU  - Herruzo I
AD  - Hospital Carlos Haya, Malaga, Spain.
FAU - Romero, Jesus
AU  - Romero J
FAU - Palacios, Amalia
AU  - Palacios A
FAU - Manas, Ana
AU  - Manas A
FAU - Samper, Pilar
AU  - Samper P
FAU - Bayo, Eloisa
AU  - Bayo E
FAU - Guedea, Ferran
AU  - Guedea F
CN  - Libro Blanco de Oncologia Radioterapica
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Clin Transl Oncol
JT  - Clinical & translational oncology : official publication of the Federation of
      Spanish Oncology Societies and of the National Cancer Institute of Mexico
JID - 101247119
SB  - IM
MH  - Humans
MH  - Neoplasms/*diagnosis/*radiotherapy
MH  - *Radiation Oncology/education/organization & administration
MH  - *Reference Books, Medical
MH  - Spain
MH  - Workforce
IR  - Algara Lopez MI
FIR - Algara Lopez, Manel Ignacio
IR  - Redondo EA
FIR - Redondo, Enrique Alonso
IR  - Alvarez Garcia C
FIR - Alvarez Garcia, Carmen
IR  - i Serra JB
FIR - i Serra, Josep Balart
IR  - Borras JM
FIR - Borras, Josep Maria
IR  - Sola AB
FIR - Sola, Albert Biete
IR  - Zulaica PB
FIR - Zulaica, Pedro Bilbao
IR  - Perea BC
FIR - Perea, Begona Caballero
IR  - Roldan PC
FIR - Roldan, Patricia Cabrera
IR  - Calvo Manuel FA
FIR - Calvo Manuel, Felipe Angel
IR  - i Duran FC
FIR - i Duran, Francesc Casas
IR  - Martinez JC
FIR - Martinez, Jorge Contreras
IR  - Lamotte de Grignon JC
FIR - Lamotte de Grignon, Jordi Craven
IR  - Delgado Rodriguez JM
FIR - Delgado Rodriguez, Jose Miguel
IR  - Saenz de Tejada LE
FIR - Saenz de Tejada, Luis Errazquin
IR  - Baron RE
FIR - Baron, Ricardo Esco
IR  - Calvo ME
FIR - Calvo, Maria Espinosa
IR  - Hernandez JE
FIR - Hernandez, Jose Exposito
IR  - Garcia NF
FIR - Garcia, Natividad Ferrer
IR  - Garcia Cabezas S
FIR - Garcia Cabezas, Sonia
IR  - Garcia Vicente F
FIR - Garcia Vicente, Feliciano
IR  - Lopez de Sagredo JG
FIR - Lopez de Sagredo, Jordi Giralt
IR  - Barrachina JG
FIR - Barrachina, Jaime Gomez-Millan
IR  - Gomez Aparicio MA
FIR - Gomez Aparicio, Maria Antonia
IR  - Gonzalez San Segundo C
FIR - Gonzalez San Segundo, Carmen
IR  - Guinot JL
FIR - Guinot, Jose Luis
IR  - de las Heras Gonzalez M
FIR - de las Heras Gonzalez, Manuel
IR  - Moron AH
FIR - Moron, Asuncion Hervas
IR  - Olasolo JJ
FIR - Olasolo, Javier Jaen
IR  - Lopez Ramirez E
FIR - Lopez Ramirez, Escarlata
IR  - i Garau MM
FIR - i Garau, Miguel Macia
IR  - de Sebastian RM
FIR - de Sebastian, Rosa Magallon
IR  - Martinez Garcia C
FIR - Martinez Garcia, Carmen
IR  - Martinez Agra M
FIR - Martinez Agra, Marta
IR  - Martinez-Paredes M
FIR - Martinez-Paredes, Maria
IR  - Garzon VM
FIR - Garzon, Victor Munoz
IR  - Murillo Gonzalez MT
FIR - Murillo Gonzalez, Maria Teresa
IR  - Masferrer JP
FIR - Masferrer, Josep Pardo
IR  - Muriel VP
FIR - Muriel, Vicente Pedraza
IR  - Bonet RP
FIR - Bonet, Rafael Peris
IR  - Verdaguer IP
FIR - Verdaguer, Ignacio Petschen
IR  - Rubio AP
FIR - Rubio, Alfredo Polo
IR  - Gomez PJ
FIR - Gomez, Pedro Jose Prada
IR  - Ramirez Vargas RD
FIR - Ramirez Vargas, Ruben Dario
IR  - Ramos Albiac M
FIR - Ramos Albiac, Monica
IR  - Ramos Aguerri A
FIR - Ramos Aguerri, Alfredo
IR  - Fernandez JR
FIR - Fernandez, Jesus Romero
IR  - Sanchez Calzado JA
FIR - Sanchez Calzado, Jose Antonio
IR  - Sanchez Perez MJ
FIR - Sanchez Perez, Maria Jose
IR  - Sanchez de Toledo Codina J
FIR - Sanchez de Toledo Codina, Jose
IR  - Santos Miranda JA
FIR - Santos Miranda, Juan Antonio
IR  - Mone JS
FIR - Mone, Jose Sole
IR  - de la Torre Tomas A
FIR - de la Torre Tomas, Alejandro
IR  - Freixa SV
FIR - Freixa, Salvador Villa
IR  - Willisch Santamaria P
FIR - Willisch Santamaria, Patricia
IR  - Grupo de Tutores
FIR - Grupo de Tutores
EDAT- 2011/06/18 06:00
MHDA- 2011/10/25 06:00
CRDT- 2011/06/18 06:00
PHST- 2011/06/18 06:00 [entrez]
PHST- 2011/06/18 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
AID - CLAT566 [pii]
AID - 10.1007/s12094-011-0672-3 [doi]
PST - ppublish
SO  - Clin Transl Oncol. 2011 Jun;13(6):385-95. doi: 10.1007/s12094-011-0672-3.


PMID- 21680172
OWN - NLM
STAT- MEDLINE
DCOM- 20111003
LR  - 20181201
IS  - 1879-0429 (Electronic)
IS  - 0958-1669 (Linking)
VI  - 22 Suppl 1
DP  - 2011 Sep
TI  - Biotechnology worldwide and the 'European Biotechnology Thematic Network'
      Association (EBTNA).
PG  - S7-14
LID - 10.1016/j.copbio.2011.05.506 [doi]
AB  - The European Biotechnology Congress 2011 held under the auspices of the European 
      Biotechnology Thematic Network Association (EBTNA) in conjunction with the
      Turkish Medical Genetics Association brings together a broad spectrum of
      biotechnologists from around the world. The subsequent abstracts indicate the
      manner in which biotechnology has permeated all aspects of research from the
      basic sciences through to small and medium enterprises and major industries. The 
      brief statements before the presentation of the abstracts aim to introduce not
      only Biotechnology in general and its importance around the world, but also the
      European Biotechnology Thematic Network Association and its aims especially
      within the framework of education and ethics in biotechnology.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Bruschi, F
AU  - Bruschi F
AD  - Dipartimento di Patologia Sperimentale, BMIE Scuola Medica, Universita di Pisa,
      Via Roma, 55 56126 Pisa, Italy.
FAU - Dundar, M
AU  - Dundar M
FAU - Gahan, P B
AU  - Gahan PB
FAU - Gartland, K
AU  - Gartland K
FAU - Szente, M
AU  - Szente M
FAU - Viola-Magni, M P
AU  - Viola-Magni MP
FAU - Akbarova, Y
AU  - Akbarova Y
LA  - eng
PT  - Journal Article
DEP - 20110615
PL  - England
TA  - Curr Opin Biotechnol
JT  - Current opinion in biotechnology
JID - 9100492
SB  - IM
MH  - Biotechnology/economics/*education/*ethics/*trends
MH  - Congresses as Topic
MH  - Europe
MH  - Humans
MH  - Industry
MH  - Public-Private Sector Partnerships
MH  - Research
MH  - Universities
EDAT- 2011/06/18 06:00
MHDA- 2011/10/04 06:00
CRDT- 2011/06/18 06:00
PHST- 2011/06/18 06:00 [entrez]
PHST- 2011/06/18 06:00 [pubmed]
PHST- 2011/10/04 06:00 [medline]
AID - S0958-1669(11)00593-3 [pii]
AID - 10.1016/j.copbio.2011.05.506 [doi]
PST - ppublish
SO  - Curr Opin Biotechnol. 2011 Sep;22 Suppl 1:S7-14. doi:
      10.1016/j.copbio.2011.05.506. Epub 2011 Jun 15.


PMID- 21680147
OWN - NLM
STAT- MEDLINE
DCOM- 20120111
LR  - 20151119
IS  - 1615-5947 (Electronic)
IS  - 0890-5096 (Linking)
VI  - 25
IP  - 7
DP  - 2011 Oct
TI  - Live case demonstrations: attitudes and ethical implications for practice.
PG  - 867-72
LID - 10.1016/j.avsg.2011.03.014 [doi]
AB  - BACKGROUND: Live case demonstrations (LCDs) are now prevalent in medical
      education courses despite ethical concerns including that they may expose
      patients to undue risk. However, there are limited data regarding many aspects of
      LCDs to help inform policies and guidelines regarding them. METHODS: We conducted
      an Internet-based survey of clinicians who have served as faculty or attended the
      2009 and 2010 professional meetings sponsored by VIVA (Vascular Interventional
      Advances). RESULTS: There were 106 VIVA 2009 respondents and 165 VIVA 2010
      respondents. Observing an LCD was more valuable than watching a prerecorded video
      for most (70% in 2009; 82% in 2010) respondents. About one-third of respondents
      thought that LCD patients are exposed to more risk than non-LCD patients.
      Respondents who had been operators were more likely to agree that LCD patients
      are exposed to more risk (p = 0.001 in 2009; p = 0.022 in 2010). Approximately
      one-third of respondents in 2009 and one-half in 2010 thought that patients
      experience direct medical benefit in an LCD. The majority (71% in 2009; 76% in
      2010) indicated that they would support the decision of a family member or friend
      to be an LCD patient, few (44% in 2009; 58% in 2010) indicated that they
      personally would agree to be an LCD patient. CONCLUSIONS: This survey provides
      new insights into the value and risk of LCDs. Obtaining the perspective of
      patients would be extremely valuable in helping to ensure that the ethical
      aspects of LCDs are addressed properly and thoroughly.
CI  - Copyright (c) 2011 Annals of Vascular Surgery Inc. Published by Elsevier Inc. All
      rights reserved.
FAU - Sugarman, Jeremy
AU  - Sugarman J
AD  - Berman Institute of Bioethics, Johns Hopkins University, Baltimore, MD 21205,
      USA. jsugarman@jhu.edu
FAU - Taylor, Holly
AU  - Taylor H
FAU - Jaff, Michael R
AU  - Jaff MR
FAU - Sullivan, Timothy M
AU  - Sullivan TM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110615
PL  - Netherlands
TA  - Ann Vasc Surg
JT  - Annals of vascular surgery
JID - 8703941
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Congresses as Topic
MH  - Education, Medical, Continuing/*ethics/methods/standards
MH  - *Ethics, Medical
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Informed Consent/ethics
MH  - Internet
MH  - Male
MH  - *Patient Safety/standards
MH  - Practice Guidelines as Topic
MH  - Risk Assessment
MH  - Surveys and Questionnaires
MH  - Video Recording/*ethics/standards
EDAT- 2011/06/18 06:00
MHDA- 2012/01/12 06:00
CRDT- 2011/06/18 06:00
PHST- 2011/02/25 00:00 [received]
PHST- 2011/03/27 00:00 [accepted]
PHST- 2011/06/18 06:00 [entrez]
PHST- 2011/06/18 06:00 [pubmed]
PHST- 2012/01/12 06:00 [medline]
AID - S0890-5096(11)00242-1 [pii]
AID - 10.1016/j.avsg.2011.03.014 [doi]
PST - ppublish
SO  - Ann Vasc Surg. 2011 Oct;25(7):867-72. doi: 10.1016/j.avsg.2011.03.014. Epub 2011 
      Jun 15.


PMID- 21680110
OWN - NLM
STAT- MEDLINE
DCOM- 20120905
LR  - 20211020
IS  - 1879-0046 (Electronic)
IS  - 0376-8716 (Linking)
VI  - 119
IP  - 1-2
DP  - 2011 Dec 1
TI  - Clinician and service user perceptions of implementing contingency management: a 
      focus group study.
PG  - 56-63
LID - 10.1016/j.drugalcdep.2011.05.016 [doi]
AB  - BACKGROUND: Contingency management (CM), despite the evidence base for its
      effectiveness, remains controversial, with sub-optimal implementation. In 2007,
      UK guidelines recommended the use of CM in publicly funded services, but uptake
      has also been minimal. Previous surveys of service providers suggest differences 
      in opinions about CM, but to date there has been no published involvement of
      service users in this debate. METHOD: Focus group methodology was used to explore
      systematically the attitudes, concerns and opinions of staff and service users
      about the use of CM, in publicly funded substance misuse services, to identify
      the key areas that may be influential in terms of implementation and outcome.
      Data were analysed thematically using the constant comparative method. RESULTS:
      70 staff and service users participated in 9 focus groups. 15 themes of
      discussion around CM were identified, grouped into four categories: how CM was
      aligned to the philosophy of substance misuse services; the practicalities of
      implementation; wider ethical concerns; and how participants perceived the
      evidence for effectiveness. CONCLUSIONS: Robust process evaluation in different
      treatment systems is needed to define the active components of CM for
      implementation. Involvement of service users in this process is essential and is 
      likely to provide valuable insights into the mechanism of action of CM and its
      effectiveness and uptake within complex treatment systems.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Sinclair, J M A
AU  - Sinclair JM
AD  - University of Southampton School of Medicine, Southampton SO14 3DT, UK.
      julia.sinclair@soton.ac.uk
FAU - Burton, A
AU  - Burton A
FAU - Ashcroft, R
AU  - Ashcroft R
FAU - Priebe, S
AU  - Priebe S
LA  - eng
GR  - 081433/Z/06/Z/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110615
PL  - Ireland
TA  - Drug Alcohol Depend
JT  - Drug and alcohol dependence
JID - 7513587
SB  - IM
MH  - Adult
MH  - Cognitive Behavioral Therapy/methods
MH  - Ethics
MH  - Female
MH  - *Focus Groups
MH  - Health Personnel/*psychology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Patients
MH  - Perception
MH  - *Physicians
MH  - Psychiatry
MH  - *Reward
MH  - Substance-Related Disorders/psychology/*therapy
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC3629561
EDAT- 2011/06/18 06:00
MHDA- 2012/09/06 06:00
CRDT- 2011/06/18 06:00
PHST- 2011/02/18 00:00 [received]
PHST- 2011/05/16 00:00 [revised]
PHST- 2011/05/16 00:00 [accepted]
PHST- 2011/06/18 06:00 [entrez]
PHST- 2011/06/18 06:00 [pubmed]
PHST- 2012/09/06 06:00 [medline]
AID - S0376-8716(11)00242-0 [pii]
AID - 10.1016/j.drugalcdep.2011.05.016 [doi]
PST - ppublish
SO  - Drug Alcohol Depend. 2011 Dec 1;119(1-2):56-63. doi:
      10.1016/j.drugalcdep.2011.05.016. Epub 2011 Jun 15.


PMID- 21680071
OWN - NLM
STAT- MEDLINE
DCOM- 20111121
LR  - 20211020
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 73
IP  - 1
DP  - 2011 Jul
TI  - Community researchers conducting health disparities research: Ethical and other
      insights from fieldwork journaling.
PG  - 145-52
LID - 10.1016/j.socscimed.2011.04.029 [doi]
AB  - Lay persons who are trained to conduct research in their own communities form an 
      essential part of many research projects. However, the effects of conducting
      research in their own communities have not been adequately explored. This paper
      examines the experiences, perceptions, and challenges faced by a group of
      community researchers during their involvement in a research project that
      examined if, and how, the relationships between mothers and their adolescent
      daughters could be harnessed to develop a daughter-initiated cervical cancer
      intervention. Seven community researchers interviewed 157 mother-daughter pairs
      in Cape Town, South Africa. We examine the use of journaling as a tool to
      document the experiences of community researchers, and we consider how journaling
      may help the community-based researcher grapple with the research process, and,
      more broadly, what such journal content illustrates with respect to the nature
      and challenges of community-engaged health research. An analysis of the content
      of the journals provides a strong indication of how personal and intimate the
      research process can be for community researchers by virtue of the background
      that they bring into the process as well as the additional weight of the research
      process itself. The complexities of navigating dual and somewhat oppositional
      roles - the role of impartial scientist or researcher and the role of invested
      community person - has been both underestimated and insufficiently researched.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Mosavel, Maghboeba
AU  - Mosavel M
AD  - Virginia Commonwealth University, Richmond, VA, United States. mmosavel@vcu.edu
FAU - Ahmed, Rashid
AU  - Ahmed R
FAU - Daniels, Doria
AU  - Daniels D
FAU - Simon, Christian
AU  - Simon C
LA  - eng
GR  - R03 CA113086/CA/NCI NIH HHS/United States
GR  - R03 CA113086-01A1/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110530
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Community Participation
MH  - Data Collection
MH  - Female
MH  - Health Services Research/*ethics
MH  - *Health Status Disparities
MH  - Humans
MH  - Interviews as Topic
MH  - *Research Personnel
MH  - South Africa
MH  - Uterine Cervical Neoplasms/prevention & control
MH  - *Writing
MH  - Young Adult
PMC - PMC3126882
MID - NIHMS300502
EDAT- 2011/06/18 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/06/18 06:00
PHST- 2010/08/12 00:00 [received]
PHST- 2011/03/31 00:00 [revised]
PHST- 2011/04/27 00:00 [accepted]
PHST- 2011/06/18 06:00 [entrez]
PHST- 2011/06/18 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0277-9536(11)00295-4 [pii]
AID - 10.1016/j.socscimed.2011.04.029 [doi]
PST - ppublish
SO  - Soc Sci Med. 2011 Jul;73(1):145-52. doi: 10.1016/j.socscimed.2011.04.029. Epub
      2011 May 30.


PMID- 21680002
OWN - NLM
STAT- MEDLINE
DCOM- 20110915
LR  - 20110711
IS  - 1527-3792 (Electronic)
IS  - 0022-5347 (Linking)
VI  - 186
IP  - 2
DP  - 2011 Aug
TI  - COPING with publication ethics.
PG  - 369-70
LID - 10.1016/j.juro.2011.05.011 [doi]
FAU - Steers, William D
AU  - Steers WD
LA  - eng
PT  - Editorial
DEP - 20110615
PL  - United States
TA  - J Urol
JT  - The Journal of urology
JID - 0376374
SB  - IM
MH  - *Codes of Ethics
MH  - Periodicals as Topic/*ethics
MH  - Publishing/*ethics
MH  - *Urology
EDAT- 2011/06/18 06:00
MHDA- 2011/09/16 06:00
CRDT- 2011/06/18 06:00
PHST- 2011/06/18 06:00 [entrez]
PHST- 2011/06/18 06:00 [pubmed]
PHST- 2011/09/16 06:00 [medline]
AID - S0022-5347(11)03969-3 [pii]
AID - 10.1016/j.juro.2011.05.011 [doi]
PST - ppublish
SO  - J Urol. 2011 Aug;186(2):369-70. doi: 10.1016/j.juro.2011.05.011. Epub 2011 Jun
      15.


PMID- 21679952
OWN - NLM
STAT- MEDLINE
DCOM- 20111228
LR  - 20220318
IS  - 1873-2380 (Electronic)
IS  - 0021-9290 (Linking)
VI  - 44
IP  - 11
DP  - 2011 Jul 28
TI  - Development of a novel intraoral measurement device to determine the
      biomechanical characteristics of the human periodontal ligament.
PG  - 2136-43
LID - 10.1016/j.jbiomech.2011.05.025 [doi]
AB  - Periodontal diseases like gingivitis and periodontitis have damaging effects on
      the periodontium and commonly affect the mechanical properties of the periodontal
      ligament (PDL), which in the end might lead to loss of teeth. Monitoring tooth
      mobility and changes of the material properties of the PDL might help in early
      diagnosis of periodontal diseases and improve their prognosis. It was the aim of 
      this study to develop a novel intraoral device to determine the biomechanical
      characteristics of the periodontal ligament. This includes the measurement of
      applied forces and resulting tooth displacement in order to investigate the
      biomechanical behaviour of the periodontium with varying loading protocols with
      respect to velocity and tooth displacement. The developed device uses a
      piezoelectric actuator to apply a displacement to a tooth's crown, and the
      resulting force is measured by an integrated force sensor. To measure the tooth
      displacement independently and non-invasively, two magnets are fixed on the
      teeth. The change in the magnetic field caused by the movement of the magnets is 
      measured by a total of 16 Hall sensors. The displacement of the tooth is
      calculated from the movement of the magnets. The device was tested in vitro on
      premolars of four porcine mandibular segments and in vivo on two volunteers. The 
      teeth were loaded with varying activation curves. Comparing the force progression
      of different activation velocities, the forces decreased with decreasing
      velocity. Intensive testing demonstrated that the device fulfils all
      requirements. After acceptance of the ethical committee, further testing in
      clinical measurements is planned.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Drolshagen, M
AU  - Drolshagen M
AD  - Endowed Chair of Oral Technology, Rheinische Friedrich-Wilhelms-University,
      Welschnonnenstr. 17, 53111 Bonn, Germany.
FAU - Keilig, L
AU  - Keilig L
FAU - Hasan, I
AU  - Hasan I
FAU - Reimann, S
AU  - Reimann S
FAU - Deschner, J
AU  - Deschner J
FAU - Brinkmann, K T
AU  - Brinkmann KT
FAU - Krause, R
AU  - Krause R
FAU - Favino, M
AU  - Favino M
FAU - Bourauel, C
AU  - Bourauel C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110615
PL  - United States
TA  - J Biomech
JT  - Journal of biomechanics
JID - 0157375
SB  - IM
MH  - Biomechanical Phenomena/physiology
MH  - Humans
MH  - Periodontal Diseases/*physiopathology
MH  - Periodontal Ligament/*physiology
MH  - Tooth/*physiology
MH  - Tooth Mobility/*physiopathology
EDAT- 2011/06/18 06:00
MHDA- 2011/12/29 06:00
CRDT- 2011/06/18 06:00
PHST- 2010/12/16 00:00 [received]
PHST- 2011/05/18 00:00 [revised]
PHST- 2011/05/18 00:00 [accepted]
PHST- 2011/06/18 06:00 [entrez]
PHST- 2011/06/18 06:00 [pubmed]
PHST- 2011/12/29 06:00 [medline]
AID - S0021-9290(11)00419-2 [pii]
AID - 10.1016/j.jbiomech.2011.05.025 [doi]
PST - ppublish
SO  - J Biomech. 2011 Jul 28;44(11):2136-43. doi: 10.1016/j.jbiomech.2011.05.025. Epub 
      2011 Jun 15.


PMID- 21679667
OWN - NLM
STAT- MEDLINE
DCOM- 20110802
LR  - 20110617
IS  - 1080-3548 (Print)
IS  - 1080-3548 (Linking)
VI  - 17
IP  - 2
DP  - 2011
TI  - Chinese drivers' risky driving and risk taking in other life situations.
PG  - 155-64
AB  - The first aim of this study was to investigate Chinese drivers' preferences to
      risk-taking behaviors encountered in daily life, including safety and health,
      finance, recreation, social areas, and ethics. The second aim was to evaluate the
      association between Chinese risky driving and other risk-taking behaviors. A
      questionnaire survey was conducted with the 324 Chinese drivers who responded.
      Through a principal component analysis an 8-factor structure was created to
      interpret different domains of risk-taking behaviors. They were risks in driving,
      ethics, recreation, gambling, abused health (voluntarily engaging in smoking and 
      binge drinking), investment, ignored health (ignoring personal health, such as
      eating expired food), and monetary social areas. The result of multiple
      regression analysis showed that drivers who were likely to engage in driving
      risks were also likely to take risks in domains of ethics, abused health,
      gambling, investment, recreation, and ignored health.
FAU - Wang, Pei
AU  - Wang P
AD  - Institute of Human Factors and Ergonomics, Department of Industrial Engineering, 
      Tsinghua University, Beijing, China. pei-wang05@mails.tsinghua.edu.cn
FAU - Rau, Pei-Luen Patrick
AU  - Rau PL
FAU - Salvendy, Gavriel
AU  - Salvendy G
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Occup Saf Ergon
JT  - International journal of occupational safety and ergonomics : JOSE
JID - 9507598
SB  - IM
MH  - Adult
MH  - Automobile Driving/*psychology
MH  - China
MH  - Female
MH  - Health Behavior
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Recreation/psychology
MH  - *Risk-Taking
EDAT- 2011/06/18 06:00
MHDA- 2011/08/04 06:00
CRDT- 2011/06/18 06:00
PHST- 2011/06/18 06:00 [entrez]
PHST- 2011/06/18 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
AID - 10.1080/10803548.2011.11076886 [doi]
PST - ppublish
SO  - Int J Occup Saf Ergon. 2011;17(2):155-64. doi: 10.1080/10803548.2011.11076886.


PMID- 21679415
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20220317
IS  - 1447-056X (Electronic)
IS  - 1444-1683 (Linking)
VI  - 10
DP  - 2011 Jun 16
TI  - Cultural aspects of primary healthcare in india: A case- based analysis.
PG  - 8
LID - 10.1186/1447-056X-10-8 [doi]
AB  - Delivering quality primary care to large populations is always challenging, and
      that is certainly the case in India. While the sheer magnitude of patients can
      create difficulties, not all challenges are about logistics. Sometimes patient
      health-seeking behaviour leads to delays in obtaining medical help for reasons
      that have more to do with culture, social practice and religious belief. When
      primary care is accessed via busy state-run outpatient departments there is often
      little time for the physician to investigate causes behind a patient's condition,
      and these factors can adversely affect patient outcomes. We consider the case of 
      a woman with somatic symptoms seemingly triggered by psychological stresses
      associated with social norms and familial cultural expectations. These
      expectations conflict with her personal and professional aspirations, and
      although she eventually receives psychiatric help and her problems are addressed,
      initially, psycho-social factors underlying her condition posed a hurdle in terms
      of accessing appropriate medical care. While for many people culture, belief and 
      social norms exert a stabilising, positive influence, in situations where
      someone's personal expectations differ significantly from accepted social norms, 
      individual autonomy can be directly challenged, and in which case, something has 
      to give. The result of such challenges can negatively impact on health and
      well-being, and for patients with immature defence mechanisms for dealing with
      inner conflict, such an experience can be damaging and ensuing somatic
      disturbances are often difficult to treat. Patients with culture-bound symptoms
      are not uncommon within primary care in India or in other Asian countries and
      communities. We argue that such cases need to be properly understood if
      satisfactory patient outcomes are to be achieved. While some causes are
      structural, having to do with how healthcare is accessed and delivered, others
      are about cultural values, social practices and beliefs. We note how some young
      adult women are adversely affected and discuss some of the ethical issues that
      arise.
FAU - Worthington, Roger P
AU  - Worthington RP
AD  - School of Medicine, Keele University, City General Hospital, Newcastle Road,
      Stoke-on-Trent, ST4 6QG, UK. r.worthington@hfac.keele.ac.uk.
FAU - Gogne, Anupriya
AU  - Gogne A
LA  - eng
PT  - Journal Article
DEP - 20110616
PL  - England
TA  - Asia Pac Fam Med
JT  - Asia Pacific family medicine
JID - 101130840
PMC - PMC3130647
EDAT- 2011/06/18 06:00
MHDA- 2011/06/18 06:01
CRDT- 2011/06/18 06:00
PHST- 2011/02/07 00:00 [received]
PHST- 2011/06/16 00:00 [accepted]
PHST- 2011/06/18 06:00 [entrez]
PHST- 2011/06/18 06:00 [pubmed]
PHST- 2011/06/18 06:01 [medline]
AID - 1447-056X-10-8 [pii]
AID - 10.1186/1447-056X-10-8 [doi]
PST - epublish
SO  - Asia Pac Fam Med. 2011 Jun 16;10:8. doi: 10.1186/1447-056X-10-8.


PMID- 21679404
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20211020
IS  - 1472-6920 (Electronic)
IS  - 1472-6920 (Linking)
VI  - 11
DP  - 2011 Jun 16
TI  - Teaching physiotherapy skills in culturally-diverse classes.
PG  - 34
LID - 10.1186/1472-6920-11-34 [doi]
AB  - BACKGROUND: Cultural competence, the ability to work in cross-cultural
      situations, has been acknowledged as a core skill for physiotherapists and other 
      health professionals. Literature in this area has focused on the rationale for
      physiotherapists to provide culturally-competent care and the effectiveness of
      various educational strategies to facilitate the acquisition of knowledge about
      cultural competence by physiotherapists and physiotherapy students. However,
      there is a paucity of research on how students with different cultural needs, who
      are attending one university class, can be accommodated within a framework of
      learning core physiotherapy skills to achieve professional standards. RESULTS:
      This paper reports on steps which were taken to resolve the specific needs of a
      culturally-diverse body of first year physiotherapy students, and the impact this
      had on teaching in a new physiotherapy program located in Greater Western Sydney,
      Australia. Physiotherapy legislative, accreditation and registration requirements
      were considered in addition to anti-discrimination legislation and the four
      ethical principles of decision making. CONCLUSIONS: Reflection on this issue and 
      the steps taken to resolve it has resulted in the development of a generic
      framework which focuses on providing quality and equitable physiotherapy
      education opportunities to all students. This framework is generalizable to other
      health professions worldwide.
FAU - Bialocerkowski, Andrea
AU  - Bialocerkowski A
AD  - School of Biomedical and Health Sciences, University of Western Sydney,
      Australia. a.bialocerkowski@uws.edu.au
FAU - Wells, Cherie
AU  - Wells C
FAU - Grimmer-Somers, Karen
AU  - Grimmer-Somers K
LA  - eng
PT  - Journal Article
DEP - 20110616
PL  - England
TA  - BMC Med Educ
JT  - BMC medical education
JID - 101088679
SB  - IM
MH  - *Cultural Diversity
MH  - Female
MH  - Humans
MH  - Male
MH  - New South Wales
MH  - Physical Therapists/*education
MH  - Physical Therapy Specialty/*education
PMC - PMC3146421
EDAT- 2011/06/18 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/06/18 06:00
PHST- 2010/12/13 00:00 [received]
PHST- 2011/06/16 00:00 [accepted]
PHST- 2011/06/18 06:00 [entrez]
PHST- 2011/06/18 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 1472-6920-11-34 [pii]
AID - 10.1186/1472-6920-11-34 [doi]
PST - epublish
SO  - BMC Med Educ. 2011 Jun 16;11:34. doi: 10.1186/1472-6920-11-34.


PMID- 21679386
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1478-4505 (Electronic)
IS  - 1478-4505 (Linking)
VI  - 9 Suppl 1
DP  - 2011 Jun 16
TI  - Getting research into policy - Herpes simplex virus type-2 (HSV-2) treatment and 
      HIV infection: international guidelines formulation and the case of Ghana.
PG  - S5
LID - 10.1186/1478-4505-9-S1-S5 [doi]
AB  - BACKGROUND: Observational epidemiological and biological data indicate clear
      synergies between Herpes simplex virus type 2 (HSV-2) and HIV, whereby HSV-2
      enhances the potential for HIV acquisition or transmission. In 2001, the World
      Health Organization (WHO) launched a call for research into the possibilities of 
      disrupting this cofactor effect through the use of antiherpetic therapy. A WHO
      Expert Meeting was convened in 2008 to review the research results. The results
      of the trials were mostly inconclusive or showed no impact. However, the WHO
      syndromic management treatment guidelines were modified to include acyclovir as
      first line therapy to treat genital ulcer disease on the basis of the high
      prevalence of HSV-2 in most settings, impact and cost-benefit of treatment on
      ulcer healing and quality of life among patients. METHODS: This paper examines
      the process through which the evidence related to HIV-HSV-2 interactions
      influenced policy at the international level and then the mechanism of
      international to national policy transfer, with Ghana as a case study. To better 
      understand the context within which national policy change occurs, special
      attention was paid to the relationships between researchers and policy-makers as 
      integral to the process of getting evidence into policy. Data from this study
      were then collected through interviews conducted with researchers, program
      managers and policy-makers working in sexual health/STI at the 2008 WHO Expert
      Meeting in Montreux, Switzerland, and in Accra, Ghana. RESULTS: The major
      findings of this study indicate that investigations into HSV-2 as a cofactor of
      HIV generated the political will necessary to reform HSV-2 treatment policy.
      Playing a pivotal role at both the international level and within the Ghanaian
      policy context were 'policy networks' formed either formally (WHO) or informally 
      (Ghana) around an issue area. These networks of professionals serve as the
      primary conduit of information between researchers and policy-makers. Donor
      influence was cited as the single strongest impetus and impediment to policy
      change nationally. CONCLUSIONS: Policy networks may serve as the primary driving 
      force of change in both international context and in the case of Ghana.
      Communication among researchers and policy-makers is critical for uptake of
      evidence and opportunities may exist to formalize policy networks and engage
      donors in a productive and ethical way.
FAU - Burris, H
AU  - Burris H
AD  - London School of Hygiene & Tropical Medicine, London, UK.
      hannahfburris@gmail.com.
FAU - Parkhurst, J
AU  - Parkhurst J
FAU - Adu-Sarkodie, Y
AU  - Adu-Sarkodie Y
FAU - Mayaud, P
AU  - Mayaud P
LA  - eng
PT  - Journal Article
DEP - 20110616
PL  - England
TA  - Health Res Policy Syst
JT  - Health research policy and systems
JID - 101170481
PMC - PMC3121136
EDAT- 2011/06/18 06:00
MHDA- 2011/06/18 06:01
CRDT- 2011/06/18 06:00
PHST- 2011/06/18 06:00 [entrez]
PHST- 2011/06/18 06:00 [pubmed]
PHST- 2011/06/18 06:01 [medline]
AID - 1478-4505-9-S1-S5 [pii]
AID - 10.1186/1478-4505-9-S1-S5 [doi]
PST - epublish
SO  - Health Res Policy Syst. 2011 Jun 16;9 Suppl 1:S5. doi: 10.1186/1478-4505-9-S1-S5.


PMID- 21678845
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20110617
IS  - 0010-6178 (Print)
IS  - 0010-6178 (Linking)
VI  - 75
IP  - 5
DP  - 2011 May
TI  - Professional ethics--business ethics.
PG  - 303
FAU - Crombie, H David
AU  - Crombie HD
LA  - eng
PT  - Editorial
PL  - United States
TA  - Conn Med
JT  - Connecticut medicine
JID - 0372745
SB  - IM
MH  - Drug Industry/*ethics
MH  - *Ethics, Business
MH  - *Ethics, Professional
MH  - Humans
MH  - Practice Management, Medical/ethics
EDAT- 2011/06/18 06:00
MHDA- 2011/07/27 06:00
CRDT- 2011/06/18 06:00
PHST- 2011/06/18 06:00 [entrez]
PHST- 2011/06/18 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
PST - ppublish
SO  - Conn Med. 2011 May;75(5):303.


PMID- 21678818
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20151119
IS  - 1932-149X (Print)
IS  - 1932-149X (Linking)
VI  - 6
IP  - 2
DP  - 2011 Mar-Apr
TI  - Strengthening hospital preparedness for chemical, biological, radiological,
      nuclear, and explosive events: clinicians' opinions regarding physician/physician
      assistant response and training.
PG  - 73-87
AB  - OBJECTIVES: This research explores the attitudes of physicians and physician
      assistants (PA) regarding response roles and responsibilities as well as training
      opinions to understand how best to partner with emergency department physicians
      and to effectively apply scarce healthcare dollars to ensure successful emergency
      preparedness. DESIGN: Physicians and PAs representing 21 specialties in two level
      I trauma public hospitals were surveyed. Participants scored statements within
      four categories regarding roles and responsibilities of clinicians in a disaster;
      barriers to participation; implementation of chemical, biological, radiological, 
      nuclear, and explosive training; and training preferences on a Likert scale of 1 
      (strongly agree) to 5 (strongly disagree). Additional open-ended questions were
      asked. RESULTS: Respondents strongly feel that they have an ethical
      responsibility to respond in a disaster situation and that other clinicians would
      be receptive to their assistance. They feel that they have clinical skills that
      could be useful in a catastrophic response effort. They are very receptive to
      additional training to enable them to respond. Respondents are neutral to
      slightly positive about whether this training should be mandated, yet requiring
      training as a condition for licensure, board certification, or credentialing was 
      slightly negative. Therefore, it is unclear how the mandate would be encouraged
      or enforced. Barriers to training include mild concerns about risk and
      malpractice, the cost of training, the time involved in training, and the cost
      for the time in training (eg, lost revenue and continuing medical education
      time). Respondents are not concerned about whether they can learn and retain
      these skills. Across all questions, there was no statistically significant
      difference in responses between the medical and surgical subspecialties.
      CONCLUSIONS: Improving healthcare preparedness to respond to a terrorist or
      natural disaster requires increased efforts at organization, education and
      training. Physicians are willing to increase their knowledge base if it is
      possible to create a mutually positive win-win environment to minimize cost and
      disruption while maximizing preparedness. There is no clear consensus on the
      implementation of this training, but to most efficiently and effectively use
      scare homeland security dollars, a dialogue must begin between the medical
      profession, medical societies, and US Department of Health and Human Services to 
      determine the best training strategies.
FAU - McInerney, Joan E
AU  - McInerney JE
AD  - School of Medicine, State University of New York at Stony Brook, New York, USA.
FAU - Richter, Anke
AU  - Richter A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Disaster Med
JT  - American journal of disaster medicine
JID - 101291100
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Bioterrorism
MH  - Chemical Terrorism
MH  - Disaster Planning/*methods
MH  - Emergency Medicine/*education
MH  - Explosions
MH  - Hospital Planning/*methods
MH  - Humans
MH  - Inservice Training
MH  - Nuclear Warfare
MH  - Physician Assistants/*psychology
MH  - Physicians/*psychology
MH  - Professional Role
MH  - Radioactive Hazard Release
MH  - Surveys and Questionnaires
EDAT- 2011/06/18 06:00
MHDA- 2011/07/27 06:00
CRDT- 2011/06/18 06:00
PHST- 2011/06/18 06:00 [entrez]
PHST- 2011/06/18 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
PST - ppublish
SO  - Am J Disaster Med. 2011 Mar-Apr;6(2):73-87.


PMID- 21678813
OWN - NLM
STAT- MEDLINE
DCOM- 20110712
LR  - 20191112
IS  - 0093-0334 (Print)
IS  - 0093-0334 (Linking)
VI  - 41
IP  - 3
DP  - 2011 May-Jun
TI  - Rethinking the ethics of physician participation in lethal injection execution.
PG  - 28-37
FAU - Nelson, Lawrence
AU  - Nelson L
AD  - Department of Philosophy and Faculty Scholar, Markkula Center for Applied Ethics,
      Santa Clara University, USA.
FAU - Ashby, Brandon
AU  - Ashby B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hastings Cent Rep
JT  - The Hastings Center report
JID - 0410447
SB  - IM
CIN - Hastings Cent Rep. 2011 May-Jun;41(3):3. PMID: 21678799
CIN - Hastings Cent Rep. 2012 Mar-Apr;42(2):4; author reply 7. PMID: 22733320
CIN - Hastings Cent Rep. 2012 Mar-Apr;42(2):4-6; author reply 7. PMID: 22768397
CIN - Hastings Cent Rep. 2012 Mar-Apr;42(2):6-7; author reply 7. PMID: 22768398
MH  - *Capital Punishment
MH  - Ethical Analysis
MH  - *Ethics, Medical
MH  - Humans
MH  - Morals
MH  - Philosophy, Medical
MH  - Suicide, Assisted/ethics
EDAT- 2011/06/18 06:00
MHDA- 2011/07/13 06:00
CRDT- 2011/06/18 06:00
PHST- 2011/06/18 06:00 [entrez]
PHST- 2011/06/18 06:00 [pubmed]
PHST- 2011/07/13 06:00 [medline]
AID - 10.1353/hcr.2011.0062 [doi]
PST - ppublish
SO  - Hastings Cent Rep. 2011 May-Jun;41(3):28-37. doi: 10.1353/hcr.2011.0062.


PMID- 21678646
OWN - NLM
STAT- MEDLINE
DCOM- 20110712
LR  - 20110616
IS  - 0017-7768 (Print)
IS  - 0017-7768 (Linking)
VI  - 150
IP  - 5
DP  - 2011 May
TI  - [Ethics in obstetrics and gynecology].
PG  - 470-4, 489
AB  - The immense progress in diagnostic and therapeutic modalities in medicine has
      forced a parallel development of ethical considerations in applying them. This is
      especially true with regard to obstetrics and gynecology, as this discipline
      encompasses within it the power to bestow life through fertility treatment, as
      well as the ability to deny them as a result of a discovery of genetic or
      structural malformation during pregnancy. In this review some of the issues in
      obstetrics and gynecology that mandate ethical guidance, as reflected from the
      current relevant literature, are presented. Furthermore, ethical issues of a more
      general nature, such as inter-colleague and teacher-student relationships are
      elaborated. The medical establishment recognizes the importance of ethics.
      However, its recommendations in various themes seem to be detached from the
      de-facto conditions in clinical practice, considering the terms in which the
      medical system actually functions. Therefore, an adaptation of ethical
      recommendations to the true nature of clinical "field" medicine is required.
FAU - Rabinerson, David
AU  - Rabinerson D
AD  - Helen Schneider's Hospital for Women, Rabin Medical Center, Petah Tikva.
      dadirabi@gmail.com
LA  - heb
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Israel
TA  - Harefuah
JT  - Harefuah
JID - 0034351
SB  - IM
MH  - *Ethics, Medical
MH  - Female
MH  - Gynecology/*ethics
MH  - Humans
MH  - Infertility/therapy
MH  - Obstetrics/*ethics
MH  - Pregnancy
EDAT- 2011/06/18 06:00
MHDA- 2011/07/13 06:00
CRDT- 2011/06/18 06:00
PHST- 2011/06/18 06:00 [entrez]
PHST- 2011/06/18 06:00 [pubmed]
PHST- 2011/07/13 06:00 [medline]
PST - ppublish
SO  - Harefuah. 2011 May;150(5):470-4, 489.


PMID- 21678635
OWN - NLM
STAT- MEDLINE
DCOM- 20110712
LR  - 20110616
IS  - 0017-7768 (Print)
IS  - 0017-7768 (Linking)
VI  - 150
IP  - 5
DP  - 2011 May
TI  - [Mitigating the moral risks of private medicine in public hospitals (SHARAP)
      through regulation and accountability].
PG  - 426-31, 492
AB  - BACKGROUND: SHARAP (the Hebrew acronym for private medical service) is an
      arrangement that allows patients in certain Israeli hospitals to choose their
      physicians in return for a fee paid, either privately or through some form of
      parallel insurance. At present, SHARAP is legally precluded from government
      hospitals but the issue is a source of public debate and the introduction of
      SHARAP into public hospitals owned by the government and health funds is
      supported by the Israel Medical Association and MK Yakov Litzman. While
      advantages to patients, hospitals and medical practitioners are acknowledged,
      these arrangements carry moral risks related to justice and fair allocation of
      resources, problems relating to conflicts of interests, the potential for
      exploitation of patients by physicians with private privileges and the potential 
      for corrupt behaviors. AIM: To address the questions: Do the advantages of these 
      arrangements justify the moral risks involved in the introduction of private
      medicine into public hospitals? Secondly, can these moral risks be mitigated
      through regulation without undermining the advantages accrued? METHOD: Ethical
      and public health policy evaluation based on empiric data and international
      experience. RESULTS: The potential advantages to patients, providers, hospitals
      and government of a SHARAP program in public hospitals may be undermined if the
      implementation does not incorporate regulatory structures. Appropriate regulatory
      precautions may mitigate most of these concerns adequately to allow all parties
      to enjoy benefits whilst diminishing actual harm incurred though injustice,
      conflicts of interest and exploitation.
FAU - Cherny, Nathan I
AU  - Cherny NI
AD  - Norman Levan Humanistic Medicine, Cancer Pain and Pall iative Medicine Service,
      Department Medical OncoLogy, Shaare Zedek Medical Center.
      chernyn@netvision.net.il
LA  - heb
PT  - English Abstract
PT  - Journal Article
PL  - Israel
TA  - Harefuah
JT  - Harefuah
JID - 0034351
SB  - IM
MH  - Conflict of Interest/legislation & jurisprudence
MH  - *Health Policy
MH  - Hospitals, Public/ethics/legislation & jurisprudence/*organization &
      administration
MH  - Humans
MH  - Israel
MH  - Medical Staff Privileges/ethics/legislation & jurisprudence/organization &
      administration
MH  - Medical Staff, Hospital/ethics/legislation & jurisprudence/*organization &
      administration
EDAT- 2011/06/18 06:00
MHDA- 2011/07/13 06:00
CRDT- 2011/06/18 06:00
PHST- 2011/06/18 06:00 [entrez]
PHST- 2011/06/18 06:00 [pubmed]
PHST- 2011/07/13 06:00 [medline]
PST - ppublish
SO  - Harefuah. 2011 May;150(5):426-31, 492.


PMID- 21678225
OWN - NLM
STAT- MEDLINE
DCOM- 20110829
LR  - 20110616
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 11
IP  - 6
DP  - 2011 Jun
TI  - Ethically preferable alternative practice: "no"; a preferable, head-to-head
      analytical approach: "maybe".
PG  - 57-9
LID - 10.1080/15265161.2011.578466 [doi]
FAU - Kirby, Jeffrey
AU  - Kirby J
AD  - Dalhousie University, Department of Bioethics, 5849 University Avenue, Halifax,
      Nova Scotia B3H 4H7, Canada. Jeffrey.Kirby@dal.ca
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2011 Jun;11(6):32-40. PMID: 21678215
MH  - Deep Sedation/*ethics
MH  - *Double Effect Principle
MH  - *Ethical Theory
MH  - Ethics, Medical
MH  - Humans
MH  - Palliative Care/*ethics
MH  - Suicide, Assisted/*ethics
MH  - Terminal Care/*ethics
MH  - Terminally Ill/psychology
MH  - *Wedge Argument
EDAT- 2011/06/17 06:00
MHDA- 2011/08/30 06:00
CRDT- 2011/06/17 06:00
PHST- 2011/06/17 06:00 [entrez]
PHST- 2011/06/17 06:00 [pubmed]
PHST- 2011/08/30 06:00 [medline]
AID - 938606709 [pii]
AID - 10.1080/15265161.2011.578466 [doi]
PST - ppublish
SO  - Am J Bioeth. 2011 Jun;11(6):57-9. doi: 10.1080/15265161.2011.578466.


PMID- 21678222
OWN - NLM
STAT- MEDLINE
DCOM- 20110829
LR  - 20110616
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 11
IP  - 6
DP  - 2011 Jun
TI  - A death of one's own: the perils and pitfalls of continuous sedation as the
      ethical alternative to lethal prescription.
PG  - 52-3
LID - 10.1080/15265161.2011.578196 [doi]
FAU - Rich, Ben A
AU  - Rich BA
AD  - University of California, Davis School of Medicine, 4150 V Street, Suite 2500,
      Sacramento, CA 95817, USA. barich@ucdavis.edu
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2011 Jun;11(6):32-40. PMID: 21678215
MH  - Deep Sedation/*ethics
MH  - Ethics, Medical
MH  - Humans
MH  - Montana
MH  - Pain/drug therapy
MH  - Palliative Care/*ethics
MH  - Practice Guidelines as Topic
MH  - Societies, Medical
MH  - Stress, Psychological/prevention & control
MH  - Suicide, Assisted/*ethics
MH  - Supreme Court Decisions
MH  - Terminal Care/*ethics
MH  - Terminally Ill/psychology
MH  - *Terminology as Topic
MH  - United States
EDAT- 2011/06/17 06:00
MHDA- 2011/08/30 06:00
CRDT- 2011/06/17 06:00
PHST- 2011/06/17 06:00 [entrez]
PHST- 2011/06/17 06:00 [pubmed]
PHST- 2011/08/30 06:00 [medline]
AID - 938601831 [pii]
AID - 10.1080/15265161.2011.578196 [doi]
PST - ppublish
SO  - Am J Bioeth. 2011 Jun;11(6):52-3. doi: 10.1080/15265161.2011.578196.


PMID- 21678219
OWN - NLM
STAT- MEDLINE
DCOM- 20110829
LR  - 20110616
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 11
IP  - 6
DP  - 2011 Jun
TI  - Clarifying the ethics of continuous sedation.
PG  - 46-7
LID - 10.1080/15265161.2011.577515 [doi]
FAU - Berger, Jeffrey T
AU  - Berger JT
AD  - Winthrop University Hospital, Mineola, NY 11501, USA. jberger@winthrop.org
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2011 Jun;11(6):32-40. PMID: 21678215
MH  - Decision Making/ethics
MH  - Deep Sedation/*ethics
MH  - Ethics, Medical
MH  - Humans
MH  - Palliative Care/*ethics
MH  - Suicide, Assisted/*ethics
MH  - Terminal Care/*ethics
MH  - Terminally Ill
EDAT- 2011/06/17 06:00
MHDA- 2011/08/30 06:00
CRDT- 2011/06/17 06:00
PHST- 2011/06/17 06:00 [entrez]
PHST- 2011/06/17 06:00 [pubmed]
PHST- 2011/08/30 06:00 [medline]
AID - 938613447 [pii]
AID - 10.1080/15265161.2011.577515 [doi]
PST - ppublish
SO  - Am J Bioeth. 2011 Jun;11(6):46-7. doi: 10.1080/15265161.2011.577515.


PMID- 21678218
OWN - NLM
STAT- MEDLINE
DCOM- 20110829
LR  - 20110616
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 11
IP  - 6
DP  - 2011 Jun
TI  - Elimination of pain versus elimination of suffering: Why CDS is ethically
      preferable to PAS.
PG  - 45-6
LID - 10.1080/15265161.2011.578197 [doi]
FAU - Tsu, Peter Shiu-Hwa
AU  - Tsu PS
AD  - Australian National University. u4079238@gmail.com
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2011 Jun;11(6):32-40. PMID: 21678215
MH  - Decision Making/ethics
MH  - Deep Sedation/*ethics
MH  - Ethics, Medical
MH  - Humans
MH  - Pain/*drug therapy
MH  - Palliative Care/*ethics
MH  - Stress, Psychological/*prevention & control
MH  - Suicide, Assisted/*ethics
MH  - Terminal Care/*ethics
MH  - Terminally Ill/psychology
EDAT- 2011/06/17 06:00
MHDA- 2011/08/30 06:00
CRDT- 2011/06/17 06:00
PHST- 2011/06/17 06:00 [entrez]
PHST- 2011/06/17 06:00 [pubmed]
PHST- 2011/08/30 06:00 [medline]
AID - 938601891 [pii]
AID - 10.1080/15265161.2011.578197 [doi]
PST - ppublish
SO  - Am J Bioeth. 2011 Jun;11(6):45-6. doi: 10.1080/15265161.2011.578197.


PMID- 21678215
OWN - NLM
STAT- MEDLINE
DCOM- 20110829
LR  - 20110616
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 11
IP  - 6
DP  - 2011 Jun
TI  - Is continuous sedation at the end of life an ethically preferable alternative to 
      physician-assisted suicide?
PG  - 32-40
LID - 10.1080/15265161.2011.577510 [doi]
AB  - The relatively new practice of continuous sedation at the end of life (CS) is
      increasingly being debated in the clinical and ethical literature. This practice 
      received much attention when a U.S. Supreme Court ruling noted that the
      availability of CS made legalization of physician-assisted suicide (PAS)
      unnecessary, as CS could alleviate even the most severe suffering. This view has 
      been widely adopted. In this article, we perform an in-depth analysis of four
      versions of this "argument of preferable alternative." Our goal is to determine
      the extent to which CS can be considered to be an alternative to PAS and to
      identify the grounds, if any, on which CS may be ethically preferable to PAS.
FAU - Raus, Kasper
AU  - Raus K
AD  - Ghent University, Belgium.
FAU - Sterckx, Sigrid
AU  - Sterckx S
FAU - Mortier, Freddy
AU  - Mortier F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
RN  - 0 (Analgesics, Opioid)
SB  - IM
CIN - Am J Bioeth. 2011 Jun;11(6):41-2. PMID: 21678216
CIN - Am J Bioeth. 2011 Jun;11(6):43-4. PMID: 21678217
CIN - Am J Bioeth. 2011 Jun;11(6):45-6. PMID: 21678218
CIN - Am J Bioeth. 2011 Jun;11(6):46-7. PMID: 21678219
CIN - Am J Bioeth. 2011 Jun;11(6):48-9. PMID: 21678220
CIN - Am J Bioeth. 2011 Jun;11(6):49-51. PMID: 21678221
CIN - Am J Bioeth. 2011 Jun;11(6):52-3. PMID: 21678222
CIN - Am J Bioeth. 2011 Jun;11(6):54-5. PMID: 21678223
CIN - Am J Bioeth. 2011 Jun;11(6):55-7. PMID: 21678224
CIN - Am J Bioeth. 2011 Jun;11(6):57-9. PMID: 21678225
CIN - Am J Bioeth. 2011 Jun;11(6):60-2. PMID: 21678226
CIN - Am J Bioeth. 2011 Jun;11(6):62-4. PMID: 21678227
CIN - Am J Bioeth. 2011 Jun;11(6):65-6. PMID: 21678228
MH  - Analgesics, Opioid/administration & dosage
MH  - Decision Making/ethics
MH  - Deep Sedation/*ethics
MH  - Ethics, Medical
MH  - Humans
MH  - Pain/*drug therapy
MH  - Palliative Care/*ethics
MH  - Stress, Psychological/*prevention & control
MH  - Suicide, Assisted/*ethics
MH  - Supreme Court Decisions
MH  - Terminal Care/*ethics
MH  - Terminally Ill/psychology
MH  - United States
EDAT- 2011/06/17 06:00
MHDA- 2011/08/30 06:00
CRDT- 2011/06/17 06:00
PHST- 2011/06/17 06:00 [entrez]
PHST- 2011/06/17 06:00 [pubmed]
PHST- 2011/08/30 06:00 [medline]
AID - 938610297 [pii]
AID - 10.1080/15265161.2011.577510 [doi]
PST - ppublish
SO  - Am J Bioeth. 2011 Jun;11(6):32-40. doi: 10.1080/15265161.2011.577510.


PMID- 21678213
OWN - NLM
STAT- MEDLINE
DCOM- 20110829
LR  - 20110616
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 11
IP  - 6
DP  - 2011 Jun
TI  - The concept of minimal risk: the need for better guidance on the ethics review
      process.
PG  - 27-9
LID - 10.1080/15265161.2011.568584 [doi]
FAU - Wada, Kyoko
AU  - Wada K
AD  - University of Western Ontario, London, Ontario N6A 4H1, Canada.
      kyoko.wada@ymail.com
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
RN  - 0 (AIDS Vaccines)
SB  - IM
CON - Am J Bioeth. 2011 Jun;11(6):5-13. PMID: 21678205
MH  - AIDS Vaccines/administration & dosage/adverse effects
MH  - Canada
MH  - Clinical Trials as Topic/*ethics/legislation & jurisprudence/methods
MH  - Community-Based Participatory Research/*ethics/legislation &
      jurisprudence/methods
MH  - Ethics Committees, Research/*standards
MH  - HIV Infections/prevention & control
MH  - Humans
MH  - Nontherapeutic Human Experimentation/ethics
MH  - Patient Selection/*ethics
MH  - Primary Prevention/ethics/methods
MH  - *Risk
EDAT- 2011/06/17 06:00
MHDA- 2011/08/30 06:00
CRDT- 2011/06/17 06:00
PHST- 2011/06/17 06:00 [entrez]
PHST- 2011/06/17 06:00 [pubmed]
PHST- 2011/08/30 06:00 [medline]
AID - 938601635 [pii]
AID - 10.1080/15265161.2011.568584 [doi]
PST - ppublish
SO  - Am J Bioeth. 2011 Jun;11(6):27-9. doi: 10.1080/15265161.2011.568584.


PMID- 21678205
OWN - NLM
STAT- MEDLINE
DCOM- 20110829
LR  - 20141120
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 11
IP  - 6
DP  - 2011 Jun
TI  - Relative versus absolute standards for everyday risk in adolescent HIV prevention
      trials: expanding the debate.
PG  - 5-13
LID - 10.1080/15265161.2011.568576 [doi]
AB  - The concept of minimal risk has been used to regulate and limit participation by 
      adolescents in clinical trials. It can be understood as setting an absolute
      standard of what risks are considered minimal or it can be interpreted as
      relative to the actual risks faced by members of the host community for the
      trial. While commentators have almost universally opposed a relative
      interpretation of the environmental risks faced by potential adolescent trial
      participants, we argue that the ethical concerns against the relative standard
      may not be as convincing as these commentators believe. Our aim is to present the
      case for a relative standard of environmental risk in order to open a debate on
      this subject. We conclude by discussing how a relative standard of environmental 
      risk could be defended in the specific case of an HIV vaccine trial among
      adolescents in South Africa.
FAU - Snyder, Jeremy
AU  - Snyder J
AD  - Snyder, Simon Fraser University, Health Sciences, 8888 University Drive, Blusson 
      Hall 11300, Burnaby, British Columbia, V5A 1S6, Canada. jcs12@sfu.ca
FAU - Miller, Cari L
AU  - Miller CL
FAU - Gray, Glenda
AU  - Gray G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
RN  - 0 (AIDS Vaccines)
SB  - IM
CIN - Am J Bioeth. 2011 Jun;11(6):W1-3. PMID: 21678202
CIN - Am J Bioeth. 2011 Jun;11(6):14-6. PMID: 21678206
CIN - Am J Bioeth. 2011 Jun;11(6):17-9. PMID: 21678207
CIN - Am J Bioeth. 2011 Jun;11(6):19-21. PMID: 21678208
CIN - Am J Bioeth. 2011 Jun;11(6):21-2. PMID: 21678209
CIN - Am J Bioeth. 2011 Jun;11(6):22-3. PMID: 21678210
CIN - Am J Bioeth. 2011 Jun;11(6):23-5. PMID: 21678211
CIN - Am J Bioeth. 2011 Jun;11(6):25-7. PMID: 21678212
CIN - Am J Bioeth. 2011 Jun;11(6):27-9. PMID: 21678213
CIN - Am J Bioeth. 2011 Jun;11(6):29-31. PMID: 21678214
MH  - AIDS Vaccines/*administration & dosage/adverse effects/immunology
MH  - *Adolescent
MH  - Clinical Trials as Topic/*ethics/methods/standards
MH  - Community-Based Participatory Research/*ethics/methods/standards
MH  - Ethics, Research
MH  - Female
MH  - Global Health
MH  - HIV Infections/immunology/*prevention & control/transmission
MH  - Hepatitis/prevention & control
MH  - Humans
MH  - Institutionalization
MH  - Intellectual Disability
MH  - Male
MH  - Nontherapeutic Human Experimentation/ethics
MH  - Patient Selection/*ethics
MH  - Primary Prevention/*ethics/methods
MH  - Research Personnel/ethics
MH  - Risk
MH  - *Risk-Taking
MH  - South Africa
MH  - *Therapeutic Equipoise
MH  - Unsafe Sex
MH  - *Vulnerable Populations
MH  - Young Adult
EDAT- 2011/06/17 06:00
MHDA- 2011/08/30 06:00
CRDT- 2011/06/17 06:00
PHST- 2011/06/17 06:00 [entrez]
PHST- 2011/06/17 06:00 [pubmed]
PHST- 2011/08/30 06:00 [medline]
AID - 938601703 [pii]
AID - 10.1080/15265161.2011.568576 [doi]
PST - ppublish
SO  - Am J Bioeth. 2011 Jun;11(6):5-13. doi: 10.1080/15265161.2011.568576.


PMID- 21678204
OWN - NLM
STAT- MEDLINE
DCOM- 20110829
LR  - 20110616
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 11
IP  - 6
DP  - 2011 Jun
TI  - It's time for bioethics to see chronic pain as an ethical issue.
PG  - 3-4
LID - 10.1080/15265161.2011.589282 [doi]
FAU - Christopher, Myra J
AU  - Christopher MJ
AD  - Center for Practical Bioethics, 1111 Main Street, 5th Floor, Kansas City, MO
      64105, USA. mchristopher@practicalbioethics.org
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Placebos)
RN  - 0 (Prescription Drugs)
SB  - IM
MH  - Analgesics, Opioid/*administration & dosage/*adverse effects
MH  - *Bioethical Issues
MH  - Chronic Disease
MH  - Contracts
MH  - Humans
MH  - Informed Consent
MH  - Pain/*drug therapy
MH  - Physician-Patient Relations
MH  - Placebos/administration & dosage
MH  - Prescription Drugs
MH  - *Refusal to Treat
MH  - Social Justice
MH  - Substance-Related Disorders/*etiology/prevention & control
MH  - *Treatment Refusal
EDAT- 2011/06/17 06:00
MHDA- 2011/08/30 06:00
CRDT- 2011/06/17 06:00
PHST- 2011/06/17 06:00 [entrez]
PHST- 2011/06/17 06:00 [pubmed]
PHST- 2011/08/30 06:00 [medline]
AID - 938601495 [pii]
AID - 10.1080/15265161.2011.589282 [doi]
PST - ppublish
SO  - Am J Bioeth. 2011 Jun;11(6):3-4. doi: 10.1080/15265161.2011.589282.


PMID- 21678203
OWN - NLM
STAT- MEDLINE
DCOM- 20110829
LR  - 20181201
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 11
IP  - 6
DP  - 2011 Jun
TI  - Fat chance getting an obstetrician in South Florida? Ethics and discrimination in
      obstetrics and gynecology.
PG  - 1-2
LID - 10.1080/15265161.2011.591210 [doi]
FAU - McGee, Glenn
AU  - McGee G
LA  - eng
PT  - Editorial
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
MH  - Female
MH  - Florida
MH  - *Gynecology/ethics/legislation & jurisprudence
MH  - *Health Services Accessibility/ethics/trends
MH  - Humans
MH  - Hyperphagia
MH  - Insurance, Liability
MH  - *Malpractice
MH  - *Obesity/complications/psychology
MH  - *Obstetrics/ethics/legislation & jurisprudence
MH  - *Physician's Role
MH  - Pregnancy
MH  - *Pregnancy Complications/etiology
MH  - *Prejudice
MH  - Stereotyping
MH  - United States
MH  - Workforce
EDAT- 2011/06/17 06:00
MHDA- 2011/08/30 06:00
CRDT- 2011/06/17 06:00
PHST- 2011/06/17 06:00 [entrez]
PHST- 2011/06/17 06:00 [pubmed]
PHST- 2011/08/30 06:00 [medline]
AID - 938601655 [pii]
AID - 10.1080/15265161.2011.591210 [doi]
PST - ppublish
SO  - Am J Bioeth. 2011 Jun;11(6):1-2. doi: 10.1080/15265161.2011.591210.


PMID- 21678168
OWN - NLM
STAT- MEDLINE
DCOM- 20120501
LR  - 20161125
IS  - 1476-8321 (Electronic)
IS  - 0887-0446 (Linking)
VI  - 26
IP  - 12
DP  - 2011 Dec
TI  - A qualitative analysis of attitudes to face transplants: contrasting views of the
      general public and medical professionals.
PG  - 1589-605
LID - 10.1080/08870446.2010.545888 [doi]
AB  - While there has been a considerable criticism and debate about face
      transplantation from ethicists, surgeons and psychologists, little is known about
      the attitudes of medical professionals and the general public whose support will 
      be necessary if face transplants are to be accepted. This study therefore
      conducted in-depth, semi-structured interviews with medical professionals (8) and
      the general public (8) to explore their understanding of and attitudes to face
      transplants. A thematic analysis was used to analyse these data. Five overarching
      themes were identified including agreement in principal, caveats and conditions, 
      medical and technical difficulties, function and appearance, and the significance
      of the human face. The analysis revealed overwhelming support in principle for
      face transplants, but with important caveats and conditions. Both groups shared
      clear representations of deserving and undeserving candidates, and concerns about
      psychological adjustment. The general public sample demonstrated little
      understanding of medical implications or the consequences of a failed graft,
      which did concern the medical professionals. Neither group showed a clear
      understanding of the psychological or social factors required to predict best
      outcomes and identify suitable candidates. Analyses revealed a stereotypical
      belief from both groups that the life of a severely disfigured recipient is
      intolerable without this operation.
FAU - Prior, Jessica J
AU  - Prior JJ
AD  - Faculty of Arts and Social Sciences, Department of Psychology, Kingston
      University, UK. j.prior@kingston.ac.uk
FAU - Klein, Orly
AU  - Klein O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110708
PL  - England
TA  - Psychol Health
JT  - Psychology & health
JID - 8807983
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - *Facial Transplantation
MH  - Female
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Middle Aged
MH  - *Public Opinion
MH  - United Kingdom
EDAT- 2011/06/17 06:00
MHDA- 2012/05/02 06:00
CRDT- 2011/06/17 06:00
PHST- 2011/06/17 06:00 [entrez]
PHST- 2011/06/17 06:00 [pubmed]
PHST- 2012/05/02 06:00 [medline]
AID - 938610356 [pii]
AID - 10.1080/08870446.2010.545888 [doi]
PST - ppublish
SO  - Psychol Health. 2011 Dec;26(12):1589-605. doi: 10.1080/08870446.2010.545888. Epub
      2011 Jul 8.


PMID- 21677843
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1568-4156 (Print)
VI  - 11 Spec Ed
DP  - 2011 Jan
TI  - Ten years of jointly commissioning health and social care in England.
PG  - e005
AB  - INTRODUCTION: Over the past two decades, the service delivery landscape across
      health and social care in England has been reshaped in order to separate the
      commissioning of services from their delivery. POLICY/PRACTICE: The market ethic 
      that underpinned this move has depicted the previously roles as unresponsive to
      the needs of service users and dominated by provider interests. As well as
      seeming to offer commissioners the chance to change the nature of provision and
      type of provider, this policy model also created a further new opportunity-for
      joint commissioning across organisational boundaries. The logic here is that if
      two or more commissioners can jointly shape their programmes then they will be
      better able to secure integrated provision across a range of separate agencies
      and professions. CONCLUSION: This article reviews the experience of joint
      commissioning across health and social care over the past decade in England. It
      contrasts the proliferation of policies against the paucity of achievements,
      seeks explanations for this situation, and offers pointers for future
      development.
FAU - Hudson, Bob
AU  - Hudson B
AD  - School of Applied Social Sciences, Elvet Riverside II, New Elvet, Durham DH1 3JT,
      UK.
LA  - eng
PT  - Journal Article
DEP - 20110307
PL  - England
TA  - Int J Integr Care
JT  - International journal of integrated care
JID - 101214424
PMC - PMC3111886
OTO - NOTNLM
OT  - front-line professionals
OT  - health and social care
OT  - joint commissioning
OT  - network development
OT  - policy developments
OT  - top-down implementation
EDAT- 2011/06/17 06:00
MHDA- 2011/06/17 06:01
CRDT- 2011/06/17 06:00
PHST- 2011/06/17 06:00 [entrez]
PHST- 2011/06/17 06:00 [pubmed]
PHST- 2011/06/17 06:01 [medline]
AID - 10.5334/ijic.553 [doi]
PST - ppublish
SO  - Int J Integr Care. 2011 Jan;11 Spec Ed:e005. doi: 10.5334/ijic.553. Epub 2011 Mar
      7.


PMID- 21677035
OWN - NLM
STAT- MEDLINE
DCOM- 20111014
LR  - 20211020
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 96
IP  - 8
DP  - 2011 Aug
TI  - The regulation of vascular endothelial growth factor by hypoxia and prostaglandin
      F(2)alpha during human endometrial repair.
PG  - 2475-83
LID - 10.1210/jc.2010-2971 [doi]
AB  - CONTEXT: The human endometrium has an exceptional capacity for repeated repair
      after menses, but its regulation remains undefined. Premenstrually, progesterone 
      levels fall and prostaglandin (PG) F(2)alpha synthesis increases, causing spiral 
      arteriole constriction. We hypothesized that progesterone withdrawal,
      PGF(2)alpha, and hypoxia increase vascular endothelial growth factor (VEGF), an
      endometrial repair factor. DESIGN AND RESULTS: Endometrial biopsies were
      collected (n = 47) with ethical approval and consent. VEGF mRNA, quantified by
      quantitative RT-PCR, was increased during menstruation (P < 0.01).VEGF protein
      was maximally secreted from proliferative endometrial explants. Treatment of an
      endometrial epithelial cell line and primary human endometrial stromal cells with
      100 nm PGF(2)alpha or hypoxia (0.5% O(2)) resulted in significant increases in
      VEGF mRNA and protein. VEGF was maximal when cells were cotreated with
      PGF(2alpha) and hypoxia simultaneously (P < 0.05-0.001). Secretory-phase
      endometrial explants also showed an increase in VEGF with cotreatment (P < 0.05).
      However, proliferative-phase explants showed no increase in VEGF on treatment
      with PGF(2)alpha and/or hypoxia. Proliferative tissue was induced to increase
      VEGF mRNA expression when exposed to progesterone and its withdrawal in vitro but
      only in the presence of hypoxia and PG. Hypoxia-inducible factor-1alpha
      (HIF-1alpha) silencing with RNA interference suppressed hypoxia-induced VEGF
      expression in endometrial cells but did not alter PGF(2)alpha-induced VEGF
      expression. CONCLUSIONS: Endometrial VEGF is increased at the time of endometrial
      repair. Progesterone withdrawal, PGF(2)alpha, and hypoxia are necessary for this 
      perimenstrual VEGF expression. Hypoxia acts via HIF-1alpha to increase VEGF,
      whereas PGF(2)alpha acts in a HIF-1alpha-independent manner. Hence, two pathways 
      regulate the expression of VEGF during endometrial repair.
FAU - Maybin, Jacqueline A
AU  - Maybin JA
AD  - Centre for Reproductive Biology, University of Edinburgh, The Queen's Medical
      Research Institute, Edinburgh EH16 4TJ, UK.
FAU - Hirani, Nikhil
AU  - Hirani N
FAU - Brown, Pamela
AU  - Brown P
FAU - Jabbour, Henry N
AU  - Jabbour HN
FAU - Critchley, Hilary O D
AU  - Critchley HO
LA  - eng
GR  - G0600048/MRC_/Medical Research Council/United Kingdom
GR  - G0600048(80179)/MRC_/Medical Research Council/United Kingdom
GR  - G1002033/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110615
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Cyclooxygenase Inhibitors)
RN  - 0 (HIF1A protein, human)
RN  - 0 (Hormone Antagonists)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (RNA, Messenger)
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 320T6RNW1F (Mifepristone)
RN  - 4G7DS2Q64Y (Progesterone)
RN  - 4TI98Z838E (Estradiol)
RN  - B7IN85G1HY (Dinoprost)
RN  - XXE1CET956 (Indomethacin)
SB  - IM
MH  - Adult
MH  - Biopsy
MH  - Cells, Cultured
MH  - Cyclooxygenase Inhibitors/pharmacology
MH  - Dinoprost/*metabolism
MH  - Endometrium/cytology/drug effects/*physiology
MH  - Estradiol/blood
MH  - Female
MH  - Hormone Antagonists/pharmacology
MH  - Humans
MH  - Hypoxia/*metabolism/*physiopathology
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/metabolism
MH  - Indomethacin/pharmacology
MH  - Menstrual Cycle/*physiology
MH  - Middle Aged
MH  - Mifepristone/pharmacology
MH  - Progesterone/antagonists & inhibitors/blood
MH  - RNA, Messenger/metabolism
MH  - Regeneration/physiology
MH  - Vascular Endothelial Growth Factor A/*genetics
MH  - Young Adult
PMC - PMC3380090
EDAT- 2011/06/17 06:00
MHDA- 2011/10/15 06:00
CRDT- 2011/06/17 06:00
PHST- 2011/06/17 06:00 [entrez]
PHST- 2011/06/17 06:00 [pubmed]
PHST- 2011/10/15 06:00 [medline]
AID - jc.2010-2971 [pii]
AID - 10.1210/jc.2010-2971 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2011 Aug;96(8):2475-83. doi: 10.1210/jc.2010-2971. Epub 
      2011 Jun 15.


PMID- 21676335
OWN - NLM
STAT- MEDLINE
DCOM- 20110909
LR  - 20110616
IS  - 1469-2147 (Electronic)
IS  - 0963-1801 (Linking)
VI  - 20
IP  - 3
DP  - 2011 Jul
TI  - A comparison of student performance between two instructional delivery methods
      for a healthcare ethics course.
PG  - 493-501
LID - 10.1017/S0963180111000181 [doi]
AB  - Healthcare ethics has become part of the standard curriculum of students in the
      health professions. The goals of healthcare ethics education are to give students
      the skills they need to identify, assess, and address ethical issues in clinical 
      practice and to develop virtuous practitioners. Incorporating the medical
      humanities into medical school, for example, is intended to foster empathy and
      professionalism among students and to provide mechanisms for enhanced physician
      well-being. Yet, despite the long-standing inclusion of the humanities in nursing
      curricula, increases in the amount and kinds of scientific knowledge essential
      for clinical practice has resulted in the erosion of the "humanistic arts" from
      nursing education. One potential solution to this challenge comes with the
      increase in interprofessional education, where students in a variety of
      healthcare professions programs come together to learn about issues common to all
      healthcare fields.
FAU - Stoddard, Hugh A
AU  - Stoddard HA
AD  - University of Nebraska College of Medicine, Omaha, NE, USA.
FAU - Schonfeld, Toby
AU  - Schonfeld T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Camb Q Healthc Ethics
JT  - Cambridge quarterly of healthcare ethics : CQ : the international journal of
      healthcare ethics committees
JID - 9208482
SB  - IM
MH  - Age Factors
MH  - Bioethics/*education
MH  - Computer-Assisted Instruction/methods
MH  - *Education, Distance/methods
MH  - Educational Measurement/*methods
MH  - Humans
MH  - Problem-Based Learning/methods
MH  - Professional Competence/standards
MH  - Teaching/*methods
EDAT- 2011/06/17 06:00
MHDA- 2011/09/10 06:00
CRDT- 2011/06/17 06:00
PHST- 2011/06/17 06:00 [entrez]
PHST- 2011/06/17 06:00 [pubmed]
PHST- 2011/09/10 06:00 [medline]
AID - S0963180111000181 [pii]
AID - 10.1017/S0963180111000181 [doi]
PST - ppublish
SO  - Camb Q Healthc Ethics. 2011 Jul;20(3):493-501. doi: 10.1017/S0963180111000181.


PMID- 21676332
OWN - NLM
STAT- MEDLINE
DCOM- 20110909
LR  - 20161125
IS  - 1469-2147 (Electronic)
IS  - 0963-1801 (Linking)
VI  - 20
IP  - 3
DP  - 2011 Jul
TI  - Egg cell preservation and the right to die in the Netherlands: citizens' choices 
      and the limits of medicine.
PG  - 449-57
LID - 10.1017/S0963180111000132 [doi]
AB  - It is a funny thing with the Dutch. On one hand, they seem preoccupied with death
      and adamant that patients be allowed to decide for themselves in what way they
      want to die. On the other, contrary to popular belief, the Dutch physician is
      allotted a very influential role in treatment decisions, far more prominent than 
      in many other Western countries. From an American perspective Dutch professional 
      ethics may seem quite paternalistic: a patient's freedom to decide to have a
      particular medical treatment is limited by the physician's professional
      assessment of the medical need of this treatment. The question arises: What is
      the relationship between the professional responsibility of Dutch physicians and 
      the right of Dutch patients to decide for themselves? This question is
      illustrated by the ongoing national debate in The Netherlands on euthanasia and
      the growing demand for a further reaching right to self-determination concerning 
      ending one's life. However, contrary to popular belief, not all Dutch ethical
      debate concerns end-of-life questions.
FAU - Touwen, Dorothea P
AU  - Touwen DP
AD  - Department of Medical Ethics and Health Law of the Leiden University Medical
      Center, The Netherlands.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Camb Q Healthc Ethics
JT  - Cambridge quarterly of healthcare ethics : CQ : the international journal of
      healthcare ethics committees
JID - 9208482
SB  - IM
MH  - Choice Behavior/*ethics
MH  - Community Participation/*trends
MH  - *Cryopreservation
MH  - Decision Making/ethics
MH  - Euthanasia/*ethics
MH  - Female
MH  - Fertility
MH  - Humans
MH  - Male
MH  - Mothers
MH  - Netherlands
MH  - *Oocytes
MH  - Paternalism
MH  - Patient Participation/trends
MH  - *Personal Autonomy
MH  - *Physician's Role
MH  - *Right to Die/ethics/legislation & jurisprudence
MH  - Socioeconomic Factors
MH  - Time Factors
MH  - Trust
EDAT- 2011/06/17 06:00
MHDA- 2011/09/10 06:00
CRDT- 2011/06/17 06:00
PHST- 2011/06/17 06:00 [entrez]
PHST- 2011/06/17 06:00 [pubmed]
PHST- 2011/09/10 06:00 [medline]
AID - S0963180111000132 [pii]
AID - 10.1017/S0963180111000132 [doi]
PST - ppublish
SO  - Camb Q Healthc Ethics. 2011 Jul;20(3):449-57. doi: 10.1017/S0963180111000132.


PMID- 21676330
OWN - NLM
STAT- MEDLINE
DCOM- 20110909
LR  - 20151119
IS  - 1469-2147 (Electronic)
IS  - 0963-1801 (Linking)
VI  - 20
IP  - 3
DP  - 2011 Jul
TI  - Public understanding of neural prosthetics in Germany: ethical, social, and
      cultural challenges.
PG  - 434-9
LID - 10.1017/S0963180111000119 [doi]
AB  - Since the development of the first neural prosthesis, that is, the cochlear
      implant in 1957, neural prosthetics have been one of the highly promising, yet
      most challenging areas of medicine, while having become a clinically accepted
      form of invasiveness into the human body. Neural prosthetic devices, of which at 
      least one part is inserted into the body, interact directly with the nervous
      system to restore or replace lost or damaged sensory, motor, or cognitive
      functions. This field is not homogenous and encompasses a variety of
      technologies, which are in various stages of development. Some devices are well
      established in clinical practice and have become routine, such as cochlear
      implants. By comparison, other technologies are in experimental phases and still 
      need to be further developed to achieve the desired results.
FAU - Laryionava, Katsiaryna
AU  - Laryionava K
AD  - Institute for History, Theory and Ethics in Medicine, RWTH Aachen University.
FAU - Gross, Dominik
AU  - Gross D
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Camb Q Healthc Ethics
JT  - Cambridge quarterly of healthcare ethics : CQ : the international journal of
      healthcare ethics committees
JID - 9208482
SB  - IM
MH  - Comprehension/ethics
MH  - Cultural Characteristics
MH  - Germany
MH  - Humans
MH  - Nervous System Diseases/surgery/*therapy
MH  - Neural Prostheses/*ethics
MH  - Newspapers as Topic/*statistics & numerical data
MH  - Periodicals as Topic/*statistics & numerical data
MH  - Prosthesis Implantation
MH  - *Public Opinion
EDAT- 2011/06/17 06:00
MHDA- 2011/09/10 06:00
CRDT- 2011/06/17 06:00
PHST- 2011/06/17 06:00 [entrez]
PHST- 2011/06/17 06:00 [pubmed]
PHST- 2011/09/10 06:00 [medline]
AID - S0963180111000119 [pii]
AID - 10.1017/S0963180111000119 [doi]
PST - ppublish
SO  - Camb Q Healthc Ethics. 2011 Jul;20(3):434-9. doi: 10.1017/S0963180111000119.


PMID- 21676326
OWN - NLM
STAT- MEDLINE
DCOM- 20110909
LR  - 20151119
IS  - 1469-2147 (Electronic)
IS  - 0963-1801 (Linking)
VI  - 20
IP  - 3
DP  - 2011 Jul
TI  - Clinical ethics committees in Norway: what do they do, and does it make a
      difference?
PG  - 389-95
LID - 10.1017/S0963180111000077 [doi]
AB  - The first clinical ethics committees (CEC) in Norway were established in 1996.
      This started as an initiative from hospital clinicians, the Norwegian Medical
      Association, and health authorities and politicians. Norwegian hospitals are, by 
      and large, publicly funded through taxation, and all inpatient treatment is free 
      of charge. Today, all the 23 hospital trusts (providing specialized and
      hospital-based healthcare services to the Norwegian population of 4.9 million
      people) have established at least one committee. Center for Medical Ethics (SME),
      University of Oslo, receives an annual amount of US$335,000 from the Ministry of 
      Health and Care Services to coordinate the committees and to facilitate
      competency building for committee members.
FAU - Forde, Reidun
AU  - Forde R
AD  - Center for Medical Ethics, University of Oslo, Norway.
FAU - Pedersen, Reidar
AU  - Pedersen R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Camb Q Healthc Ethics
JT  - Cambridge quarterly of healthcare ethics : CQ : the international journal of
      healthcare ethics committees
JID - 9208482
SB  - IM
MH  - *Ethics Committees, Clinical/organization & administration/standards/trends
MH  - *Ethics Consultation/organization & administration/standards/trends
MH  - Hospitals/ethics
MH  - Humans
MH  - Norway
MH  - *Patient Advocacy
MH  - *Quality Assurance, Health Care
MH  - Surveys and Questionnaires
EDAT- 2011/06/17 06:00
MHDA- 2011/09/10 06:00
CRDT- 2011/06/17 06:00
PHST- 2011/06/17 06:00 [entrez]
PHST- 2011/06/17 06:00 [pubmed]
PHST- 2011/09/10 06:00 [medline]
AID - S0963180111000077 [pii]
AID - 10.1017/S0963180111000077 [doi]
PST - ppublish
SO  - Camb Q Healthc Ethics. 2011 Jul;20(3):389-95. doi: 10.1017/S0963180111000077.


PMID- 21676325
OWN - NLM
STAT- MEDLINE
DCOM- 20110909
LR  - 20110616
IS  - 1469-2147 (Electronic)
IS  - 0963-1801 (Linking)
VI  - 20
IP  - 3
DP  - 2011 Jul
TI  - Assisting countries in establishing national bioethics committees: UNESCO's
      Assisting Bioethics Committees project.
PG  - 380-8
LID - 10.1017/S0963180111000065 [doi]
AB  - The Universal Declaration on Bioethics and Human Rights adopted by UNESCO in 2005
      advocates for the establishment of independent, multidisciplinary, and pluralist 
      ethics committees at national, regional, local, or institutional levels. The
      purpose of these committees is (a) to evaluate the relevant ethical, legal,
      scientific, and social issues related to research involving human beings; (b) to 
      provide advice on ethical problems in clinical settings; (c) to assess scientific
      and technological development, formulate recommendations, and contribute to the
      preparation of guidelines; and (d) to foster debate, education, and public
      awareness of and engagement in bioethics (Article 19). Already in the very first 
      draft of the Declaration the need to promote and establish national bioethics
      committees was mentioned. Although the text was gradually elaborated, the same
      basic idea has been preserved throughout the process of drafting, negotiating,
      and adopting the text.
FAU - ten Have, Henk
AU  - ten Have H
AD  - Center for Healthcare Ethics at Duquesne University in Pittsburgh, Pennsylvania, 
      USA.
FAU - Dikenou, Christophe
AU  - Dikenou C
FAU - Feinholz, Dafna
AU  - Feinholz D
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Camb Q Healthc Ethics
JT  - Cambridge quarterly of healthcare ethics : CQ : the international journal of
      healthcare ethics committees
JID - 9208482
SB  - IM
MH  - *Advisory Committees/organization & administration
MH  - *Bioethics/education/trends
MH  - Ethics, Research/education
MH  - Guidelines as Topic/standards
MH  - Human Rights
MH  - Humans
MH  - *International Cooperation
MH  - United Nations
EDAT- 2011/06/17 06:00
MHDA- 2011/09/10 06:00
CRDT- 2011/06/17 06:00
PHST- 2011/06/17 06:00 [entrez]
PHST- 2011/06/17 06:00 [pubmed]
PHST- 2011/09/10 06:00 [medline]
AID - S0963180111000065 [pii]
AID - 10.1017/S0963180111000065 [doi]
PST - ppublish
SO  - Camb Q Healthc Ethics. 2011 Jul;20(3):380-8. doi: 10.1017/S0963180111000065.


PMID- 21676324
OWN - NLM
STAT- MEDLINE
DCOM- 20110909
LR  - 20211203
IS  - 1469-2147 (Electronic)
IS  - 0963-1801 (Linking)
VI  - 20
IP  - 3
DP  - 2011 Jul
TI  - Ethics, kawa, and the constitution: transformation of the system of ethical
      review in Aotearoa New Zealand.
PG  - 367-79
LID - 10.1017/S0963180111000053 [doi]
AB  - New Zealand is a South Pacific nation with a history of British colonization
      since the 19th century. It has a population of over four million people and, like
      other indigenous societies such as in Australia and Canada, Maori are now a
      minority in their land, and their experience of colonization is that of being
      dominated by settlers to the detriment of their own systems of society.
FAU - Tupara, Hope
AU  - Tupara H
AD  - Massey University, Palmerston North, New Zealand.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Camb Q Healthc Ethics
JT  - Cambridge quarterly of healthcare ethics : CQ : the international journal of
      healthcare ethics committees
JID - 9208482
SB  - IM
MH  - Constitution and Bylaws
MH  - *Cultural Characteristics
MH  - Ethical Analysis
MH  - *Ethical Review
MH  - Ethics Committees
MH  - *Ethnicity
MH  - *Health
MH  - Humans
MH  - New Zealand
MH  - *Philosophy
EDAT- 2011/06/17 06:00
MHDA- 2011/09/10 06:00
CRDT- 2011/06/17 06:00
PHST- 2011/06/17 06:00 [entrez]
PHST- 2011/06/17 06:00 [pubmed]
PHST- 2011/09/10 06:00 [medline]
AID - S0963180111000053 [pii]
AID - 10.1017/S0963180111000053 [doi]
PST - ppublish
SO  - Camb Q Healthc Ethics. 2011 Jul;20(3):367-79. doi: 10.1017/S0963180111000053.


PMID- 21676322
OWN - NLM
STAT- MEDLINE
DCOM- 20110909
LR  - 20110616
IS  - 1469-2147 (Electronic)
IS  - 0963-1801 (Linking)
VI  - 20
IP  - 3
DP  - 2011 Jul
TI  - In the ruins of Babel: pitfalls on the way toward a universal language for
      research ethics and benefit sharing.
PG  - 341-55
LID - 10.1017/S096318011100003X [doi]
AB  - At the end of a paper on international research ethics published in the
      July-August 2010 issue of the Hastings Center Report, London and Zollman argue
      the need for grounding our duties in international medical and health-related
      research within a broader normative framework of social, distributive, and
      rectificatory justice. The same goes for Thomas Pogge, who, in a whole range of
      publications during the past years, has argued for a human-rights-based approach 
      to international research. In a thought-provoking paper in the June 2010 issue of
      the American Journal of Bioethics, Angela J. Ballantyne argues that "the global
      bioethics priority" in medical and health-related research ethics today is how to
      do research fairly in an unjust world.
FAU - Solbakk, Jan Helge
AU  - Solbakk JH
AD  - Section for Medical Ethics, University of Oslo, Norway.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Camb Q Healthc Ethics
JT  - Cambridge quarterly of healthcare ethics : CQ : the international journal of
      healthcare ethics committees
JID - 9208482
SB  - IM
MH  - *Communication
MH  - *Cooperative Behavior
MH  - Developing Countries
MH  - *Ethics, Research
MH  - Helsinki Declaration
MH  - Human Rights
MH  - Humans
MH  - *Information Dissemination/ethics
MH  - *International Cooperation
MH  - Poverty
EDAT- 2011/06/17 06:00
MHDA- 2011/09/10 06:00
CRDT- 2011/06/17 06:00
PHST- 2011/06/17 06:00 [entrez]
PHST- 2011/06/17 06:00 [pubmed]
PHST- 2011/09/10 06:00 [medline]
AID - S096318011100003X [pii]
AID - 10.1017/S096318011100003X [doi]
PST - ppublish
SO  - Camb Q Healthc Ethics. 2011 Jul;20(3):341-55. doi: 10.1017/S096318011100003X.


PMID- 21675988
OWN - NLM
STAT- MEDLINE
DCOM- 20111111
LR  - 20110616
IS  - 1468-5922 (Electronic)
IS  - 0021-8774 (Linking)
VI  - 56
IP  - 3
DP  - 2011 Jun
TI  - John Beebe in conversation with Beverley Zabriskie.
PG  - 407-23
LID - 10.1111/j.1468-5922.2011.01917.x [doi]
AB  - John Beebe speaks with Beverley Zabriskie about the central motifs of his life
      and depth psychological experience, and how these informed his choice of vocation
      as psychiatrist, Jungian analyst, educator and author. Dr. Beebe narrates how he 
      moved beyond the fate assigned the son of a needy mother and abandoning father.
      He illustrates how the role his family expected him to fill constellated
      archetypal motifs--the magical or divine curative child, the whiz kid--from which
      he had then to disidentify for the sake of becoming an individual with a personal
      voice and capacity to express his own true values. He tells of his
      differentiation and search for completion through the perspective of Jung's
      psychological types theory. He also reflects on the evolution of Jungian analytic
      theory and practice generally, his editorship of the JAP and the San Francisco
      Jung Institute Library Journal, his confrontation with analytic homophobia, and
      the emerging quality of professional and personal relationships in relation to
      ethics and to love. He assesses Jung's courage and integrity as displayed through
      the release of Jung's Red Book, and his own quest for an organic and
      psychological moral stance expressed in his benchmark book, Integrity in Depth.
CI  - (c) 2011, The Society of Analytical Psychology.
FAU - Beebe, John
AU  - Beebe J
AD  - Jungian Psychoanalytic Association.
FAU - Zabriskie, Beverley
AU  - Zabriskie B
LA  - eng
PT  - Autobiography
PT  - Biography
PT  - Historical Article
PT  - Interview
PL  - England
TA  - J Anal Psychol
JT  - The Journal of analytical psychology
JID - 0376573
SB  - IM
MH  - History, 20th Century
MH  - Jungian Theory/history
MH  - Psychoanalysis/history
MH  - Psychoanalytic Therapy
MH  - San Francisco
PS  - Beebe J
FPS - Beebe, John
EDAT- 2011/06/17 06:00
MHDA- 2011/11/15 06:00
CRDT- 2011/06/17 06:00
PHST- 2011/06/17 06:00 [entrez]
PHST- 2011/06/17 06:00 [pubmed]
PHST- 2011/11/15 06:00 [medline]
AID - 10.1111/j.1468-5922.2011.01917.x [doi]
PST - ppublish
SO  - J Anal Psychol. 2011 Jun;56(3):407-23. doi: 10.1111/j.1468-5922.2011.01917.x.


PMID- 21675983
OWN - NLM
STAT- MEDLINE
DCOM- 20111111
LR  - 20110616
IS  - 1468-5922 (Electronic)
IS  - 0021-8774 (Linking)
VI  - 56
IP  - 3
DP  - 2011 Jun
TI  - Introduction: Fragmentation of the Unus Mundus.
PG  - 375-80
LID - 10.1111/j.1468-5922.2011.01915_1.x [doi]
AB  - This panel is a series of presentations by a father and his three sons. The first
      is a critique of the concept of the Unus Mundus, an idea that goes back at least 
      as far as Plato's Cave in western intellectual history. A longing for unchanging 
      foundational ideas lies at the core of much of our culture, psychology, and
      theology. The subsequent presentations describe various unforeseen, destructive
      results stemming from the perspective of the Unus Mundus. The first example is of
      persons with Alzheimer's disease, whose singular subjectivity is often ignored
      because they are seen as a category. They are 'Alzheimer-ed', subtly enabling
      those around them to avoid an anxiety-producing encounter with their enigmatic
      otherness. Another important perspective is the modernist re-construction of city
      spaces that has resulted in the loss of an organic sense of containment. The
      lengthy horizon of the grand boulevards seemed like openings upon infinity, often
      provoking panic and agoraphobia, as seen in the work of Edvard Munch. Lastly, the
      genocidal tendencies of modern times epitomize the dangers of totalizing, Utopian
      ideas. Violent elimination may be visited upon groups or peoples who are deemed
      'impure', as besmirching idealized social visions. Such examples illustrate some 
      of the ethical dangers of conceptualizations related to the Unus Mundus.
CI  - (c) 2011, The Society of Analytical Psychology.
FAU - Hinton, Ladson 3rd
AU  - Hinton L 3rd
AD  - North Pacific Institute for Analytical Psychology, USA. ladson3@comcast.net
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Anal Psychol
JT  - The Journal of analytical psychology
JID - 0376573
SB  - IM
MH  - Agoraphobia
MH  - Alzheimer Disease
MH  - Culture
MH  - Humans
MH  - *Jungian Theory
EDAT- 2011/06/17 06:00
MHDA- 2011/11/15 06:00
CRDT- 2011/06/17 06:00
PHST- 2011/06/17 06:00 [entrez]
PHST- 2011/06/17 06:00 [pubmed]
PHST- 2011/11/15 06:00 [medline]
AID - 10.1111/j.1468-5922.2011.01915_1.x [doi]
PST - ppublish
SO  - J Anal Psychol. 2011 Jun;56(3):375-80. doi: 10.1111/j.1468-5922.2011.01915_1.x.


PMID- 21675534
OWN - NLM
STAT- MEDLINE
DCOM- 20110712
LR  - 20110616
IS  - 0026-2102 (Print)
IS  - 0026-2102 (Linking)
VI  - 93
IP  - 4
DP  - 2011 Apr
TI  - Dental ethics and the sudden closure of chain dental offices.
PG  - 22
FAU - Maihofer, Michael
AU  - Maihofer M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Mich Dent Assoc
JT  - The Journal of the Michigan Dental Association
JID - 7505621
MH  - *Ethics, Dental
MH  - *Health Facility Closure
MH  - Humans
MH  - Michigan
MH  - Practice Management, Dental/*ethics
MH  - Professional Corporations/*ethics
MH  - Refusal to Treat/*ethics
EDAT- 2011/06/17 06:00
MHDA- 2011/07/13 06:00
CRDT- 2011/06/17 06:00
PHST- 2011/06/17 06:00 [entrez]
PHST- 2011/06/17 06:00 [pubmed]
PHST- 2011/07/13 06:00 [medline]
PST - ppublish
SO  - J Mich Dent Assoc. 2011 Apr;93(4):22.


PMID- 21675184
OWN - NLM
STAT- MEDLINE
DCOM- 20110708
LR  - 20191210
IS  - 0022-4545 (Print)
IS  - 0022-4545 (Linking)
VI  - 151
IP  - 3
DP  - 2011 May-Jun
TI  - Does the Defining Issues Test measure ethical judgment ability or political
      position?
PG  - 314-30
AB  - This article addresses the construct validity of the Defining Issues Test of
      ethical judgment (DIT/DIT-2). Alleging a political bias in the test, Emler and
      colleagues (1983, 1998, 1999, 2007), show that conservatives score higher when
      asked to fake as liberals, implying that they understand the reasoning associated
      with "higher" moral development but avoid items they see as liberally biased. DIT
      proponents challenge the internal validity of faking studies, advocating an
      explained-variance validation. This study takes a new approach: Adult
      participants complete the DIT-2, then evaluate the raw responses of others to
      discern political orientation and ethical development. Results show that
      individuals scoring higher on the DIT-2 rank others' ethical judgment in a way
      consistent with DIT-2-based rankings. Accuracy at assessing political
      orientation, however, is low. Results support the DIT-2's validity as a measure
      of ethical development, not an expression of political position.
FAU - Bailey, Charles D
AU  - Bailey CD
AD  - University of Memphis, Fogelman College of Business and Economics, School of
      Accountancy, 3665 Central Ave., Memphis, TN 38152, USA. cbailey2@memphis.edu
LA  - eng
PT  - Journal Article
PT  - Validation Study
PL  - United States
TA  - J Soc Psychol
JT  - The Journal of social psychology
JID - 0376372
SB  - IM
MH  - Adult
MH  - *Aptitude
MH  - *Ethics
MH  - Female
MH  - Humans
MH  - *Judgment
MH  - Male
MH  - Middle Aged
MH  - *Politics
MH  - Psychological Tests/*statistics & numerical data
MH  - Psychometrics/statistics & numerical data
MH  - Reproducibility of Results
MH  - Retrospective Moral Judgment
MH  - Young Adult
EDAT- 2011/06/17 06:00
MHDA- 2011/07/09 06:00
CRDT- 2011/06/17 06:00
PHST- 2011/06/17 06:00 [entrez]
PHST- 2011/06/17 06:00 [pubmed]
PHST- 2011/07/09 06:00 [medline]
AID - 10.1080/00224545.2010.481690 [doi]
PST - ppublish
SO  - J Soc Psychol. 2011 May-Jun;151(3):314-30. doi: 10.1080/00224545.2010.481690.


PMID- 21675025
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20181201
IS  - 0023-9852 (Print)
IS  - 0023-9852 (Linking)
VI  - 59
IP  - 1
DP  - 2011 Jan-Mar
TI  - First Regional Conference on Biomedical Ethics in Medical Schools. Organized by
      the Salim El-Hoss Bioethics and Professionalism Program at AUB-FM.
PG  - 44-7
FAU - Arawi, Thalia
AU  - Arawi T
AD  - Salim El-Hoss Bioethics and Professionalism Program, American University of
      Beirut, Faculty of Medicine, P.O. Box 11-0236, Beirut. ta16@aub.edu.lb
LA  - eng
PT  - Congress
PL  - Lebanon
TA  - J Med Liban
JT  - Le Journal medical libanais. The Lebanese medical journal
JID - 0375352
SB  - IM
MH  - *Education, Medical, Graduate
MH  - Ethics, Medical/*education
MH  - Humans
EDAT- 2011/06/17 06:00
MHDA- 2011/07/27 06:00
CRDT- 2011/06/17 06:00
PHST- 2011/06/17 06:00 [entrez]
PHST- 2011/06/17 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
PST - ppublish
SO  - J Med Liban. 2011 Jan-Mar;59(1):44-7.


PMID- 21675023
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20110615
IS  - 0023-9852 (Print)
IS  - 0023-9852 (Linking)
VI  - 59
IP  - 1
DP  - 2011 Jan-Mar
TI  - Gaps in end-of-life care.
PG  - 37-9
AB  - End-of-life care is an important aspect of medical practice. Individual
      physicians and the medical community must be committed to the compassionate and
      competent provision of care to dying patients and their families. Patients
      rightfully expect their physicians to care for them and provide them with medical
      assistance as they are dying. To care properly for patients near the end of life,
      the physician must understand that palliative care entails addressing physical,
      psychosocial, and spiritual needs and that patients may at times require
      palliative treatment in an acute care context. To provide palliative care, the
      physician must be up to date on the proper use of opioids and the legality and
      propriety of using high doses of opioids as necessary to relieve suffering. Good 
      symptom control; ongoing involvement with the patient; and physical,
      psychological, and spiritual support are the hallmarks of quality end-of-life
      care. Care of patients near the end of life, however, has a moral, psychological,
      and interpersonal intensity that distinguishes it from most other clinical
      encounters. With appropriate education, physicians can play a key role to improve
      care for patients and families who are living with advanced life-threatening
      illness. Although some issues (e.g., the role of physician-assisted death in
      addressing suffering) remain very controversial, there is much common ground
      based on the application of the four major principles of medical ethics,
      nonmaleficence, beneficence, autonomy, and justice.
FAU - Daher, Michel
AU  - Daher M
AD  - Medical Ethics & Bioethics Teaching Program, University of Balamand Saint George 
      Hospital, Beirut, Lebanon. mndaher@inco.com.lb
LA  - eng
PT  - Journal Article
PL  - Lebanon
TA  - J Med Liban
JT  - Le Journal medical libanais. The Lebanese medical journal
JID - 0375352
SB  - IM
MH  - Humans
MH  - Medical Futility
MH  - *Palliative Care
MH  - *Physician's Role
MH  - *Terminally Ill
EDAT- 2011/06/17 06:00
MHDA- 2011/07/27 06:00
CRDT- 2011/06/17 06:00
PHST- 2011/06/17 06:00 [entrez]
PHST- 2011/06/17 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
PST - ppublish
SO  - J Med Liban. 2011 Jan-Mar;59(1):37-9.


PMID- 21675020
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20110615
IS  - 0023-9852 (Print)
IS  - 0023-9852 (Linking)
VI  - 59
IP  - 1
DP  - 2011 Jan-Mar
TI  - [Is good genetic counseling possible with good ethical principals?].
PG  - 23-6
AB  - A good genetic counseling, followed by appropriate examinations, sometimes
      requires the participation of any family members--parents, grandparents, aunts,
      uncles, cousins--thus leading to accurate knowledge of the genome of each
      individual. This is far from inconsequential. While genetic testing can disrupt
      life plans, influence the choice of spouse or procreation, or a sense of guilt
      among healthy individuals, they may also reveal some families information not
      sought from the first glance as false paternity or a positive result from a
      person still asymptomatic. How then react? Is there an appropriate attitude to
      adopt? If yes, which one? Is it free of any side effects?
FAU - Megarbane, Andre
AU  - Megarbane A
AD  - Unite de Genetique medicale et Laboratoire associe INSERM a l'Unite UMR-S 910,
      Universite Saint-Joseph, Beyrouth, Liban. megarbane@usj.edu.lb
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Un bon conseil genetique est-il conciliable avec une bonne pratique ethique?
PL  - Lebanon
TA  - J Med Liban
JT  - Le Journal medical libanais. The Lebanese medical journal
JID - 0375352
SB  - IM
MH  - Confidentiality
MH  - *Ethics, Medical
MH  - *Genetic Counseling
MH  - Humans
EDAT- 2011/06/17 06:00
MHDA- 2011/07/27 06:00
CRDT- 2011/06/17 06:00
PHST- 2011/06/17 06:00 [entrez]
PHST- 2011/06/17 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
PST - ppublish
SO  - J Med Liban. 2011 Jan-Mar;59(1):23-6.


PMID- 21675019
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20110615
IS  - 0023-9852 (Print)
IS  - 0023-9852 (Linking)
VI  - 59
IP  - 1
DP  - 2011 Jan-Mar
TI  - Ethical issues in assisted reproductive technologies.
PG  - 17-22
FAU - Mroueh, Adnan
AU  - Mroueh A
AD  - Department of Obstetrics and Gynecology, American University Medical Center,
      Beirut, Lebanon. am36@aub.edu.lb
LA  - eng
PT  - Journal Article
PL  - Lebanon
TA  - J Med Liban
JT  - Le Journal medical libanais. The Lebanese medical journal
JID - 0375352
SB  - IM
MH  - Female
MH  - Humans
MH  - Male
MH  - Oocyte Donation
MH  - Reproductive Techniques, Assisted/*ethics
MH  - Sex Preselection/ethics
MH  - Spermatozoa
MH  - Tissue and Organ Procurement/ethics
EDAT- 2011/06/17 06:00
MHDA- 2011/07/27 06:00
CRDT- 2011/06/17 06:00
PHST- 2011/06/17 06:00 [entrez]
PHST- 2011/06/17 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
PST - ppublish
SO  - J Med Liban. 2011 Jan-Mar;59(1):17-22.


PMID- 21675018
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20110615
IS  - 0023-9852 (Print)
IS  - 0023-9852 (Linking)
VI  - 59
IP  - 1
DP  - 2011 Jan-Mar
TI  - Is medical ethics education effective?
PG  - 12-6
FAU - Rosoff, Philip M
AU  - Rosoff PM
AD  - Trent Center for Bioethics, Humanities and History of Medicine, Department of
      Pediatrics, Duke University Medical Center, Durham 27710, USA.
      philip.rosoff@duke.edu
LA  - eng
PT  - Journal Article
PL  - Lebanon
TA  - J Med Liban
JT  - Le Journal medical libanais. The Lebanese medical journal
JID - 0375352
SB  - IM
MH  - Codes of Ethics
MH  - Education, Medical, Graduate
MH  - Ethics, Medical/*education
MH  - Humans
EDAT- 2011/06/17 06:00
MHDA- 2011/07/27 06:00
CRDT- 2011/06/17 06:00
PHST- 2011/06/17 06:00 [entrez]
PHST- 2011/06/17 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
PST - ppublish
SO  - J Med Liban. 2011 Jan-Mar;59(1):12-6.


PMID- 21675015
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20110615
IS  - 0023-9852 (Print)
IS  - 0023-9852 (Linking)
VI  - 59
IP  - 1
DP  - 2011 Jan-Mar
TI  - Foreword. Towards implementing medical ethics and bioethics education in Lebanon.
PG  - 2-3
FAU - Arawi, Thalia
AU  - Arawi T
AD  - American University of Beirut, Faculty of Medicine. ta16@aub.edu.lb
FAU - Daher, Michel
AU  - Daher M
FAU - Kallab, Kamal
AU  - Kallab K
FAU - Sabra, Ramzi
AU  - Sabra R
LA  - eng
PT  - Introductory Journal Article
PL  - Lebanon
TA  - J Med Liban
JT  - Le Journal medical libanais. The Lebanese medical journal
JID - 0375352
SB  - IM
MH  - Bioethics/*education
MH  - Education, Medical, Graduate
MH  - Ethics, Clinical/*education
MH  - Humans
MH  - Lebanon
MH  - Students, Medical
EDAT- 2011/06/17 06:00
MHDA- 2011/07/27 06:00
CRDT- 2011/06/17 06:00
PHST- 2011/06/17 06:00 [entrez]
PHST- 2011/06/17 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
PST - ppublish
SO  - J Med Liban. 2011 Jan-Mar;59(1):2-3.


PMID- 21674900
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20110614
IS  - 1660-9379 (Print)
IS  - 1660-9379 (Linking)
VI  - 7
IP  - 292
DP  - 2011 Apr 27
TI  - [Miscellaneous ethics (2)].
PG  - 932-3
FAU - Nau, Jean-Yves
AU  - Nau JY
AD  - jeanyves.nau@gmail.com
LA  - fre
PT  - Journal Article
TT  - Miscellanees ethiques (2).
PL  - Switzerland
TA  - Rev Med Suisse
JT  - Revue medicale suisse
JID - 101219148
SB  - IM
MH  - *Bioethical Issues
MH  - Embryo Research/*ethics
MH  - Embryo, Mammalian
MH  - Female
MH  - Humans
EDAT- 2011/06/17 06:00
MHDA- 2011/07/27 06:00
CRDT- 2011/06/17 06:00
PHST- 2011/06/17 06:00 [entrez]
PHST- 2011/06/17 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
PST - ppublish
SO  - Rev Med Suisse. 2011 Apr 27;7(292):932-3.


PMID- 21658637
OWN - NLM
STAT- MEDLINE
DCOM- 20110902
LR  - 20110610
IS  - 1873-5010 (Electronic)
IS  - 1569-1993 (Linking)
VI  - 10 Suppl 2
DP  - 2011 Jun
TI  - Diversified harmony: supranational and domestic regulation of pediatric clinical 
      trials in the European Union.
PG  - S183-98
LID - 10.1016/S1569-1993(11)60022-2 [doi]
AB  - Over the past decades, considerable legislative effort has been made to
      facilitate and encourage clinical research in the European Union (EU). Hereby,
      specific attention has been paid to the urgent need to conduct research in
      minors. In this article, we will analyze the regulation that currently governs
      pediatric clinical research conduct at the supranational level of the EU and at
      the level of individual EU member states. Our analysis will focus on the way in
      which the national and supranational legal frameworks address five ethical issues
      that are specific to pediatric clinical research: (a) informed consent, (b) the
      necessity to conduct research in minor subjects, (c) the interests of the subject
      concerned, (d) the risks and burdens involved, and (e) the pediatric expertise of
      protocol review committees. We conclude by discussing the harmonization and
      diversification of the legal requirements that govern pediatric clinical research
      in the EU.
CI  - Copyright (c) 2011 European Cystic Fibrosis Society. Published by Elsevier B.V.
      All rights reserved.
FAU - Pinxten, Wim
AU  - Pinxten W
AD  - Centre for Biomedical Ethics and Law, K U Leuven, Leuven, Belgium.
      wim.pinxten@med.kuleuven.be
FAU - Dierickx, Kris
AU  - Dierickx K
FAU - Nys, Herman
AU  - Nys H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - J Cyst Fibros
JT  - Journal of cystic fibrosis : official journal of the European Cystic Fibrosis
      Society
JID - 101128966
SB  - IM
MH  - Child
MH  - Clinical Trials as Topic/*legislation & jurisprudence/*standards/trends
MH  - Cooperative Behavior
MH  - Europe
MH  - *European Union
MH  - Humans
MH  - Legislation as Topic/*trends
MH  - Pediatrics/*standards
EDAT- 2011/06/17 06:00
MHDA- 2011/09/03 06:00
CRDT- 2011/06/11 06:00
PHST- 2011/06/11 06:00 [entrez]
PHST- 2011/06/17 06:00 [pubmed]
PHST- 2011/09/03 06:00 [medline]
AID - S1569-1993(11)60022-2 [pii]
AID - 10.1016/S1569-1993(11)60022-2 [doi]
PST - ppublish
SO  - J Cyst Fibros. 2011 Jun;10 Suppl 2:S183-98. doi: 10.1016/S1569-1993(11)60022-2.


PMID- 21674823
OWN - NLM
STAT- MEDLINE
DCOM- 20120105
LR  - 20211020
IS  - 1332-8166 (Electronic)
IS  - 0353-9504 (Linking)
VI  - 52
IP  - 3
DP  - 2011 Jun
TI  - Ethical aspects of human biobanks: a systematic review.
PG  - 262-79
AB  - AIM: To systematically assess the existing literature on ethical aspects of human
      biobanks. METHOD: We searched the Web of Science and PubMed databases to find
      studies addressing ethical problems in biobanks with no limits set (study design,
      study population, time period, or language of publication). All identified
      articles published until November 2010 were included. We analyzed the type of
      published articles, journals publishing them, involvement of
      countries/institutions, year of publication, and citations received, and
      qualitatively assessed every article in order to identify ethical issues
      addressed by the majority of published research on human biobanking. RESULTS:
      Hundred and fifty four studies satisfied our review criteria. The studies mainly 
      came from highly developed countries and were all published in the last two
      decades, with over half of them published in 2009 or 2010. They most commonly
      discussed the informed consent, privacy and identifiability, return of results to
      participants, importance of public trust, involvement of children,
      commercialization, the role of ethics boards, international data exchange,
      ownership of samples, and benefit sharing. CONCLUSIONS: The focus on ethical
      aspects is strongly present through the whole biobanking research field. Although
      there is a consensus on the old and most typical ethical issues, with further
      development of the field and increasingly complex structure of human biobanks,
      these issues will likely continue to arise and accumulate, hence requiring
      constant re-appraisal and continuing discussion.
FAU - Budimir, Danijela
AU  - Budimir D
AD  - University of Split School of Medicine, Split, Croatia.
FAU - Polasek, Ozren
AU  - Polasek O
FAU - Marusic, Ana
AU  - Marusic A
FAU - Kolcic, Ivana
AU  - Kolcic I
FAU - Zemunik, Tatijana
AU  - Zemunik T
FAU - Boraska, Vesna
AU  - Boraska V
FAU - Jeroncic, Ana
AU  - Jeroncic A
FAU - Boban, Mladen
AU  - Boban M
FAU - Campbell, Harry
AU  - Campbell H
FAU - Rudan, Igor
AU  - Rudan I
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
PL  - Croatia
TA  - Croat Med J
JT  - Croatian medical journal
JID - 9424324
SB  - IM
MH  - Bibliometrics
MH  - Databases, Factual
MH  - Ethics Committees, Research
MH  - *Ethics, Research
MH  - *Genetic Privacy
MH  - Global Health
MH  - Humans
MH  - Informed Consent
MH  - Tissue Banks/*ethics/legislation & jurisprudence
MH  - Trust
MH  - United States
PMC - PMC3118708
EDAT- 2011/06/16 06:00
MHDA- 2012/01/06 06:00
CRDT- 2011/06/16 06:00
PHST- 2011/06/16 06:00 [entrez]
PHST- 2011/06/16 06:00 [pubmed]
PHST- 2012/01/06 06:00 [medline]
AID - 10.3325/cmj.2011.52.262 [doi]
PST - ppublish
SO  - Croat Med J. 2011 Jun;52(3):262-79. doi: 10.3325/cmj.2011.52.262.


PMID- 21674434
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20131121
IS  - 1439-0221 (Electronic)
IS  - 0032-0943 (Linking)
VI  - 77
IP  - 11
DP  - 2011 Jul
TI  - Sharing the benefits of biodiversity: a new international protocol and its
      implications for research and development.
PG  - 1221-7
LID - 10.1055/s-0031-1279978 [doi]
AB  - Equitable sharing of the benefits of biodiversity is one of the main objectives
      of the Convention on Biological Diversity (CBD). Yet understanding of the CBD
      rules and principles on access and benefit sharing, as well as how they apply to 
      biodiversity-based research and development remains limited. In October 2010, the
      CBD adopted additional rules on access and benefit sharing. These rules--known as
      the Nagoya Protocol--provide clarification on several important issues, including
      the applicability of access and benefit sharing to research on biochemical
      compounds and processes. As a result, the Nagoya Protocol constitutes an
      important opportunity for institutions, organizations, and companies committed to
      ethical practices regarding biodiversity.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Oliva, Maria Julia
AU  - Oliva MJ
AD  - Union for Ethical BioTrade, Geneva, Switzerland. Julia@ethicalbiotrade.org
LA  - eng
PT  - Journal Article
DEP - 20110614
PL  - Germany
TA  - Planta Med
JT  - Planta medica
JID - 0066751
RN  - 0 (Biological Products)
SB  - IM
MH  - *Biodiversity
MH  - Biological Products
MH  - *Conservation of Natural Resources
MH  - Decision Making
MH  - *Internationality
MH  - Plants/chemistry
MH  - Research/legislation & jurisprudence/organization & administration
EDAT- 2011/06/16 06:00
MHDA- 2011/10/25 06:00
CRDT- 2011/06/16 06:00
PHST- 2011/06/16 06:00 [entrez]
PHST- 2011/06/16 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
AID - 10.1055/s-0031-1279978 [doi]
PST - ppublish
SO  - Planta Med. 2011 Jul;77(11):1221-7. doi: 10.1055/s-0031-1279978. Epub 2011 Jun
      14.


PMID- 21673871
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1178-7015 (Electronic)
IS  - 1178-7015 (Linking)
VI  - 4
DP  - 2011
TI  - Minimally invasive aesthetic procedures in young adults.
PG  - 19-26
LID - 10.2147/CCID.S17467 [doi]
AB  - Age is a significant factor in modifying specific needs when it comes to medical 
      aesthetic procedures. In this review we will focus on young adults in their third
      decade of life and review minimally invasive aesthetic procedures other than
      cosmetics and cosmeceuticals. Correction of asymmetries, correction after body
      modifying procedures, and facial sculpturing are important issues for young
      adults. The implication of aesthetic medicine as part of preventive medicine is a
      major ethical challenge that differentiates aesthetic medicine from fashion.
FAU - Wollina, Uwe
AU  - Wollina U
AD  - Department of Dermatology and Allergology, Academic Teaching Hospital
      Dresden-Friedrichstadt, Dresden, Germany;
FAU - Goldman, Alberto
AU  - Goldman A
LA  - eng
PT  - Journal Article
DEP - 20110325
PL  - New Zealand
TA  - Clin Cosmet Investig Dermatol
JT  - Clinical, cosmetic and investigational dermatology
JID - 101543449
PMC - PMC3108279
OTO - NOTNLM
OT  - acne scars
OT  - boxcar scars
OT  - fillers
OT  - ice pick scars
EDAT- 2011/06/16 06:00
MHDA- 2011/06/16 06:01
CRDT- 2011/06/16 06:00
PHST- 2011/03/24 00:00 [received]
PHST- 2011/06/16 06:00 [entrez]
PHST- 2011/06/16 06:00 [pubmed]
PHST- 2011/06/16 06:01 [medline]
AID - 10.2147/CCID.S17467 [doi]
AID - ccid-4-019 [pii]
PST - ppublish
SO  - Clin Cosmet Investig Dermatol. 2011;4:19-26. doi: 10.2147/CCID.S17467. Epub 2011 
      Mar 25.


PMID- 21673746
OWN - NLM
STAT- MEDLINE
DCOM- 20120214
LR  - 20211020
IS  - 1476-5438 (Electronic)
IS  - 1018-4813 (Linking)
VI  - 19
IP  - 11
DP  - 2011 Nov
TI  - Opinions and intentions of parents of an autistic child toward genetic research
      results: two typical profiles.
PG  - 1127-32
LID - 10.1038/ejhg.2011.106 [doi]
AB  - Returning results to research participants is increasingly acknowledged in
      research ethics guidelines. But few research teams actually do it or provide
      mechanisms for offering it as an option. We explored the perspective of parents
      of an autistic child participating in genetic research. In all, 388
      questionnaires were sent to 194 parents; 158 questionnaires were completed (89
      mothers and 69 fathers), giving a response rate of 41%. 97% of respondents
      (n=153) fully expressed a strong desire to receive research results, either
      general or individual ones. The survey solicited parents' opinions as to what
      means could be put in place to return research results. The majority held the
      research team responsible for returning individual results (79.7%, n=126). They
      indicated that it should occur at the completion of the research project (69%,
      n=109), by mail (75.3%, n=119). Over three quarters felt the Ministry of Health
      should cover the associated costs (77.8%, n=123). If the communication of
      individual findings, whether positive or negative, were to be possible, these
      would allow some respondents 'to be prepared for the future' (37%, n=57), without
      necessarily having practical benefits (21%, n=32), but at least bringing them
      'relief or understanding' (14%, n=21). Moreover, parents were clear about the
      difference between research and clinical settings. This study underlines the
      importance of broadening the discussion about the communication of research
      results, especially individual ones. We believe that the integration of different
      perspectives--those of researchers, clinicians, ethics committees and
      participants--will enrich the debate and offer enlightenment for future ethical
      guidelines.
FAU - Baret, Laurence
AU  - Baret L
AD  - Department of Social and Preventive Medicine, Faculty of Medicine, Universite de 
      Montreal, Montreal, QC, Canada.
FAU - Godard, Beatrice
AU  - Godard B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110615
PL  - England
TA  - Eur J Hum Genet
JT  - European journal of human genetics : EJHG
JID - 9302235
SB  - IM
MH  - Adult
MH  - *Attitude to Health
MH  - Autistic Disorder/diagnosis/*genetics
MH  - Child
MH  - Child, Preschool
MH  - Ethics, Research
MH  - Female
MH  - *Genetic Research
MH  - Humans
MH  - *Intention
MH  - Male
MH  - Middle Aged
MH  - Parents/*psychology
MH  - Surveys and Questionnaires
PMC - PMC3198138
EDAT- 2011/06/16 06:00
MHDA- 2012/02/15 06:00
CRDT- 2011/06/16 06:00
PHST- 2011/06/16 06:00 [entrez]
PHST- 2011/06/16 06:00 [pubmed]
PHST- 2012/02/15 06:00 [medline]
AID - ejhg2011106 [pii]
AID - 10.1038/ejhg.2011.106 [doi]
PST - ppublish
SO  - Eur J Hum Genet. 2011 Nov;19(11):1127-32. doi: 10.1038/ejhg.2011.106. Epub 2011
      Jun 15.


PMID- 21673229
OWN - NLM
STAT- MEDLINE
DCOM- 20120227
LR  - 20220409
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 260
IP  - 3
DP  - 2011 Sep
TI  - Rectal cancer: assessment of complete response to preoperative combined radiation
      therapy with chemotherapy--conventional MR volumetry versus diffusion-weighted MR
      imaging.
PG  - 734-43
LID - 10.1148/radiol.11102467 [doi]
AB  - PURPOSE: To determine diagnostic performance of diffusion-weighted (DW) magnetic 
      resonance (MR) imaging for assessment of complete tumor response (CR) after
      combined radiation therapy with chemotherapy (CRT) in patients with locally
      advanced rectal cancer (LARC) by means of volumetric signal intensity
      measurements and apparent diffusion coefficient (ADC) measurements and to compare
      the performance of DW imaging with that of T2-weighted MR volumetry. MATERIALS
      AND METHODS: A retrospective analysis of 50 patients with LARC, for whom clinical
      and imaging data were retrieved from a previous imaging study approved by the
      local institutional ethical committee and for which all patients provided
      informed consent, was conducted. Patients underwent pre- and post-CRT standard
      T2-weighted MR and DW MR. Two independent readers placed free-hand regions of
      interest (ROIs) in each tumor-containing section on both data sets to determine
      pre- and post-CRT tumor volumes and tumor volume reduction rates (volume). ROIs
      were copied to an ADC map to calculate tumor ADCs. Histopathologic findings were 
      the standard of reference. Receiver operating characteristic (ROC) curves were
      generated to compare performance of T2-weighted and DW MR volumetry and ADC. The 
      intraclass correlation coefficient (ICC) was used to evaluate interobserver
      variability and the correlation between T2-weighted and DW MR volumetry. RESULTS:
      Areas under the ROC curve (AUCs) for identification of a CR that was based on
      pre-CRT volume, post-CRT volume, and volume, respectively, were 0.57, 0.70, and
      0.84 for T2-weighted MR versus 0.63, 0.93, and 0.92 for DW MR volumetry (P = .15,
      .02, .42). Pre- and post-CRT ADC and ADC AUCs were 0.55, 0.54, and 0.51,
      respectively. Interobserver agreement was excellent for all pre-CRT measurements 
      (ICC, 0.91-0.96) versus good (ICC, 0.61-0.79) for post-CRT measurements. ICC
      between T2-weighted and DW MR volumetry was excellent (0.97) for pre-CRT
      measurements versus fair (0.25) for post-CRT measurements. CONCLUSION: Post-CRT
      DW MR volumetry provided high diagnostic performance in assessing CR and was
      significantly more accurate than T2-weighted MR volumetry. Post-CRT DW MR was
      equally as accurate as volume measurements of both T2-weighted and DW MR. Pre-CRT
      volumetry and ADC were not reliable.
FAU - Curvo-Semedo, Luis
AU  - Curvo-Semedo L
AD  - Radiology University Clinic, Coimbra University Hospital, Coimbra, Portugal.
FAU - Lambregts, Doenja M J
AU  - Lambregts DM
FAU - Maas, Monique
AU  - Maas M
FAU - Thywissen, Thomas
AU  - Thywissen T
FAU - Mehsen, Rana T
AU  - Mehsen RT
FAU - Lammering, Guido
AU  - Lammering G
FAU - Beets, Geerard L
AU  - Beets GL
FAU - Caseiro-Alves, Filipe
AU  - Caseiro-Alves F
FAU - Beets-Tan, Regina G H
AU  - Beets-Tan RG
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110614
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Antineoplastic Agents)
SB  - IM
CIN - Radiology. 2012 Apr;263(1):311. PMID: 22438457
MH  - Aged
MH  - Aged, 80 and over
MH  - Antineoplastic Agents/*therapeutic use
MH  - Diffusion Magnetic Resonance Imaging/*methods
MH  - Female
MH  - Humans
MH  - Imaging, Three-Dimensional/*methods
MH  - Male
MH  - Middle Aged
MH  - Preoperative Care/methods
MH  - Radiotherapy, Conformal/*methods
MH  - Rectal Neoplasms/*diagnosis/*therapy
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Treatment Outcome
EDAT- 2011/06/16 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/06/16 06:00
PHST- 2011/06/16 06:00 [entrez]
PHST- 2011/06/16 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - radiol.11102467 [pii]
AID - 10.1148/radiol.11102467 [doi]
PST - ppublish
SO  - Radiology. 2011 Sep;260(3):734-43. doi: 10.1148/radiol.11102467. Epub 2011 Jun
      14.


PMID- 21673120
OWN - NLM
STAT- MEDLINE
DCOM- 20111201
LR  - 20110726
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 4
DP  - 2011 Jul
TI  - A critical lens on culture in nursing practice.
PG  - 548-59
LID - 10.1177/0969733011408048 [doi]
AB  - Increasing evidence demonstrates that the Aboriginal population experience
      greater health disparities and receive a lower quality of health care services.
      The Canadian Nurses Association (CNA) code of ethics states that nurses are
      required to incorporate culture into all domains of their nursing practice and
      ethical care. The aim of this article is to examine the concepts of cultural
      competency and cultural safety by way of relational ethics. To address these
      disparities in health care, cultural competency training programs are being
      widely advised. Recent research into cultural safety has not only recognized the 
      importance of culture in nursing practice and organizational structures, but also
      extended the concepts to the culture of the client. In recognizing this
      diversity, nurses must pay close attention to their relationships with their
      clients. It is argued that the answers lie in relational ethics, which honors
      indigenous people's connection to self, others, the environment, and the
      universe.
FAU - Bourque Bearskin, R Lisa
AU  - Bourque Bearskin RL
AD  - Faculty of Nursing, University of Alberta, Canada. rbourque@ualberta.ca
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110614
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Canada
MH  - *Cultural Competency
MH  - Health Services, Indigenous/*organization & administration
MH  - Healthcare Disparities
MH  - Humans
MH  - *Indians, North American
MH  - Nurse-Patient Relations/*ethics
MH  - Nursing Methodology Research
MH  - Transcultural Nursing/education
EDAT- 2011/06/16 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/06/16 06:00
PHST- 2011/06/16 06:00 [entrez]
PHST- 2011/06/16 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 0969733011408048 [pii]
AID - 10.1177/0969733011408048 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Jul;18(4):548-59. doi: 10.1177/0969733011408048. Epub 2011 Jun 
      14.


PMID- 21673119
OWN - NLM
STAT- MEDLINE
DCOM- 20120510
LR  - 20120202
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 19
IP  - 1
DP  - 2012 Jan
TI  - Accession to the European Union 2001-2010: a reflection on some of the ethical
      issues for nursing.
PG  - 160-6
LID - 10.1177/0969733011404587 [doi]
AB  - Since 2001, the Commission of the European Union has instigated Peer Reviews to
      help countries preparing to accede to the European Union. Added to this has been 
      the provision of workshops and individual expert inputs. This article recounts
      the experiences of the author in this process. It focuses on how a single
      directive has revealed major ethical challenges for nurses, their national
      associations and state governments as they seek to implement the changes
      required. In particular a sub-agenda has emerged relating to general education,
      access to higher education and the position of women in these countries. The
      ethical challenges include freedom to practice and creation of competent
      authorities to provide proper oversight of the health care professions. In 2011, 
      the directive is being reviewed and this article offers arguments for its
      continuation, even in an unreformed state.
FAU - Keighley, Tom
AU  - Keighley T
AD  - Royal College of Nursing, 86 Saunders Ness Road, London, UK.
      nurprc@nursing.u-net.com
LA  - eng
PT  - Journal Article
DEP - 20110614
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - *Ethics, Nursing
MH  - *European Union
MH  - Humans
MH  - *Legislation, Nursing
MH  - Nursing/*organization & administration
EDAT- 2011/06/16 06:00
MHDA- 2012/05/11 06:00
CRDT- 2011/06/16 06:00
PHST- 2011/06/16 06:00 [entrez]
PHST- 2011/06/16 06:00 [pubmed]
PHST- 2012/05/11 06:00 [medline]
AID - 0969733011404587 [pii]
AID - 10.1177/0969733011404587 [doi]
PST - ppublish
SO  - Nurs Ethics. 2012 Jan;19(1):160-6. doi: 10.1177/0969733011404587. Epub 2011 Jun
      14.


PMID- 21673118
OWN - NLM
STAT- MEDLINE
DCOM- 20111201
LR  - 20110726
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 4
DP  - 2011 Jul
TI  - Ethical decision-making in nursing homes: influence of organizational factors.
PG  - 514-25
LID - 10.1177/0969733011403553 [doi]
AB  - In this article we report findings from a qualitative study that explored how
      doctors and nurses in nursing homes describe professional collaboration around
      dying patients. The study also examined the consequences this can have for the
      life-prolonging treatment of patients and the care of them and their relatives.
      Nine doctors and 10 nurses from 10 Norwegian nursing homes were interviewed about
      their experience of decision-making processes on life-prolonging treatment and
      care. The findings reveal that the frameworks for the professional collaboration 
      and organization of physicians and nurses prevent patient treatment and care
      complying with ethical considerations and the law. These conditions have a
      challenging impact on the care of dying patients and their relatives.
FAU - Dreyer, Anne
AU  - Dreyer A
AD  - Section for Medical Ethics, Department of General Practice and Community
      Medicine, Aalesund University College, University of Oslo, Norway. aod@hials.no
FAU - Forde, Reidun
AU  - Forde R
FAU - Nortvedt, Per
AU  - Nortvedt P
LA  - eng
PT  - Journal Article
DEP - 20110614
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Decision Making/*ethics
MH  - Ethics, Institutional
MH  - Humans
MH  - Life Support Care/*ethics/psychology
MH  - Norway
MH  - Nursing Homes/ethics/*organization & administration
MH  - *Physician-Nurse Relations
MH  - Qualitative Research
EDAT- 2011/06/16 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/06/16 06:00
PHST- 2011/06/16 06:00 [entrez]
PHST- 2011/06/16 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 0969733011403553 [pii]
AID - 10.1177/0969733011403553 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Jul;18(4):514-25. doi: 10.1177/0969733011403553. Epub 2011 Jun 
      14.


PMID- 21673017
OWN - NLM
STAT- MEDLINE
DCOM- 20120301
LR  - 20211020
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 11
DP  - 2011 Nov
TI  - Research, engagement and public bioethics: promoting socially robust science.
PG  - 698-701
LID - 10.1136/jme.2010.041954 [doi]
AB  - Citizens today are increasingly expected to be knowledgeable about and prepared
      to engage with biomedical knowledge. In this article, I wish to reframe this
      'public understanding of science' project, and place fresh emphasis on public
      understandings of research: an engagement with the everyday laboratory practices 
      of biomedicine and its associated ethics, rather than with specific scientific
      facts. This is not based on an assumption that non-scientists are 'ignorant' and 
      are thus unable to 'appropriately' use or debate science; rather, it is
      underpinned by an empirically-grounded observation that some individuals may be
      unfamiliar with certain specificities of particular modes of research and ethical
      frameworks, and, as a consequence, have their autonomy compromised when invited
      to participate in biomedical investigations. Drawing on the perspectives of
      participants in my own sociological research on the social and ethical dimensions
      of neuroscience, I argue that public understanding of biomedical research and its
      ethics should be developed both at the community level and within the research
      moment itself in order to enhance autonomy and promote more socially robust
      science. Public bioethics will have to play a key role in such an endeavour, and 
      indeed will contribute in important ways to the opening up of new spaces of
      symmetrical engagement between bioethicists, scientists and wider publics-and
      hence to the democratisation of the bioethical enterprise.
FAU - Pickersgill, Martyn D
AU  - Pickersgill MD
AD  - Centre for Population Health Sciences, Medical School, Teviot Place, University
      of Edinburgh, Edinburgh EH8 9AG, UK. martyn.pickersgill@ed.ac.uk
LA  - eng
GR  - 087439/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110614
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Attitude to Health
MH  - *Bioethics
MH  - Biomedical Research/education/*ethics/standards
MH  - Humans
MH  - *Public Opinion
MH  - Science/education/ethics/standards
PMC - PMC3540974
MID - EMS50871
OID - NLM: EMS50871
EDAT- 2011/06/16 06:00
MHDA- 2012/03/02 06:00
CRDT- 2011/06/16 06:00
PHST- 2011/06/16 06:00 [entrez]
PHST- 2011/06/16 06:00 [pubmed]
PHST- 2012/03/02 06:00 [medline]
AID - jme.2010.041954 [pii]
AID - 10.1136/jme.2010.041954 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Nov;37(11):698-701. doi: 10.1136/jme.2010.041954. Epub 2011
      Jun 14.


PMID- 21672937
OWN - NLM
STAT- MEDLINE
DCOM- 20120315
LR  - 20120910
IS  - 1471-8391 (Electronic)
IS  - 0007-1420 (Linking)
VI  - 100
DP  - 2011
TI  - The ethics of disclosing genetic diagnosis for Alzheimer's disease: do we need a 
      new paradigm?
PG  - 7-21
LID - 10.1093/bmb/ldr023 [doi]
AB  - INTRODUCTION OR BACKGROUND: Genetic testing for rare Mendelian disorders
      represents the dominant ethical paradigm in clinical and professional practice.
      Predictive testing for Huntington's disease is the model against which other
      kinds of genetic testing are evaluated, including testing for Alzheimer's
      disease. SOURCES OF DATA: This paper retraces the historical development of
      ethical reasoning in relation to predictive genetic testing and reviews a range
      of ethical, sociological and psychological literature from the 1970s to the
      present. AREAS OF AGREEMENT: In the past, ethical reasoning has embodied a
      distinct style whereby normative principles are developed from a dominant disease
      exemplar. AREAS OF CONTROVERSY: This reductionist approach to formulating ethical
      frameworks breaks down in the case of disease susceptibility. GROWING POINTS:
      Recent developments in the genetics of Alzheimer's disease present a significant 
      case for reconsidering the ethics of disclosing risk for common complex diseases.
      Disclosing the results of susceptibility testing for Alzheimer's disease has
      different social, psychological and behavioural consequences. Furthermore, what
      genetic susceptibility means to individuals and their families is diffuse and
      often mitigated by other factors and concerns. AREAS TIMELY FOR DEVELOPING
      RESEARCH: The ethics of disclosing a genetic diagnosis of susceptibility is
      contingent on whether professionals accept that probabilistic risk information is
      in fact 'diagnostic' and it will rely substantially on empirical evidence of how 
      people actually perceive, recall and communicate complex risk information.
FAU - Arribas-Ayllon, Michael
AU  - Arribas-Ayllon M
AD  - Cardiff School of Social Sciences, Cardiff University, Cardiff, UK.
      arribas-ayllonm@cf.ac.uk
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110614
PL  - England
TA  - Br Med Bull
JT  - British medical bulletin
JID - 0376542
RN  - 0 (Apolipoprotein E4)
SB  - IM
MH  - Alzheimer Disease/*diagnosis/genetics
MH  - Apolipoprotein E4/genetics
MH  - Ethics, Medical
MH  - Genetic Predisposition to Disease
MH  - Genetic Testing/*ethics
MH  - Humans
MH  - Truth Disclosure/*ethics
EDAT- 2011/06/16 06:00
MHDA- 2012/03/16 06:00
CRDT- 2011/06/16 06:00
PHST- 2011/06/16 06:00 [entrez]
PHST- 2011/06/16 06:00 [pubmed]
PHST- 2012/03/16 06:00 [medline]
AID - ldr023 [pii]
AID - 10.1093/bmb/ldr023 [doi]
PST - ppublish
SO  - Br Med Bull. 2011;100:7-21. doi: 10.1093/bmb/ldr023. Epub 2011 Jun 14.


PMID- 21672898
OWN - NLM
STAT- MEDLINE
DCOM- 20111004
LR  - 20151119
IS  - 1745-6614 (Electronic)
IS  - 1052-6773 (Linking)
VI  - 2011
IP  - 42
DP  - 2011
TI  - Biobanking in a fast moving world: an international perspective.
PG  - 50-1
LID - 10.1093/jncimonographs/lgr005 [doi]
AB  - Diseases including the main chronic "killer" diseases have a global dimension and
      so has biobanking, the main cornerstone for biomarker discovery, validation and
      implementation in prevention, diagnosis, or therapy. Interconnecting biobanks
      associated with cohort studies or collections of diseased tissues raises many
      issues in terms of ethics, governance, regulations, technical standardization,
      quality control, and sharing of specimens and data. In this perspective article, 
      we briefly address the importance of international networks of biobanks, identify
      the main challenges, and discuss different models of such networks, balancing the
      needs for centralization of specimens and resources with the reality of
      delocalized collection activities, in particular in a clinical context.
FAU - Hewitt, Robert
AU  - Hewitt R
AD  - Biopreservation and Biobanking, Aix-en-Provence, France.
FAU - Hainaut, Pierre
AU  - Hainaut P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Natl Cancer Inst Monogr
JT  - Journal of the National Cancer Institute. Monographs
JID - 9011255
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Biomarkers, Tumor/*analysis
MH  - Global Health
MH  - Humans
MH  - International Cooperation
MH  - Neoplasms/diagnosis/*therapy
MH  - Reference Standards
MH  - Specimen Handling/methods/*standards
MH  - Tissue Banks/organization & administration/*standards
MH  - Total Quality Management/ethics/legislation & jurisprudence/standards
EDAT- 2011/06/16 06:00
MHDA- 2011/10/05 06:00
CRDT- 2011/06/16 06:00
PHST- 2011/06/16 06:00 [entrez]
PHST- 2011/06/16 06:00 [pubmed]
PHST- 2011/10/05 06:00 [medline]
AID - lgr005 [pii]
AID - 10.1093/jncimonographs/lgr005 [doi]
PST - ppublish
SO  - J Natl Cancer Inst Monogr. 2011;2011(42):50-1. doi:
      10.1093/jncimonographs/lgr005.


PMID- 21672889
OWN - NLM
STAT- MEDLINE
DCOM- 20111004
LR  - 20110615
IS  - 1745-6614 (Electronic)
IS  - 1052-6773 (Linking)
VI  - 2011
IP  - 42
DP  - 2011
TI  - An NCI perspective on creating sustainable biospecimen resources.
PG  - 1-7
LID - 10.1093/jncimonographs/lgr006 [doi]
AB  - High-quality biospecimens with appropriate clinical annotation are critical in
      the era of personalized medicine. It is now widely recognized that biospecimen
      resources need to be developed and operated under established scientific,
      technical, business, and ethical/legal standards. To date, such standards have
      not been widely practiced, resulting in variable biospecimen quality that may
      compromise research efforts. The National Cancer Institute (NCI) Office of
      Biorepositories and Biospecimen Research (OBBR) was established in 2005 to
      coordinate NCI's biospecimen resource activities and address those issues that
      affect access to the high-quality specimens and data necessary for its research
      enterprises as well as the broader translational research field. OBBR and the NCI
      Biorepository Coordinating Committee developed NCI's "Best Practices for
      Biospecimen Resources" after consultation with a broad array of experts. A
      Biospecimen Research Network was established to fund research to develop
      additional evidence-based practices. Although these initiatives will improve the 
      overall availability of high-quality specimens and data for cancer research, OBBR
      has been authorized to implement a national biobanking effort, cancer HUman
      Biobank (caHUB). caHUB will address systematically the gaps in knowledge needed
      to improve the state-of-the-science and strengthen the standards for human
      biobanking. This commentary outlines the progressive efforts by NCI in technical,
      governance, and economic considerations that will be important as the new caHUB
      enterprise is undertaken.
FAU - Vaught, Jimmie
AU  - Vaught J
AD  - Office of Biorepositories and Biospecimen Research, National Cancer Institute,
      National Institutes of Health, Department of Health and Human Services,
      Rockville, MD 20892, USA. vaughtj@mail.nih.gov
FAU - Rogers, Joyce
AU  - Rogers J
FAU - Myers, Kimberly
AU  - Myers K
FAU - Lim, Mark David
AU  - Lim MD
FAU - Lockhart, Nicole
AU  - Lockhart N
FAU - Moore, Helen
AU  - Moore H
FAU - Sawyer, Sherilyn
AU  - Sawyer S
FAU - Furman, Jeffrey L
AU  - Furman JL
FAU - Compton, Carolyn
AU  - Compton C
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Natl Cancer Inst Monogr
JT  - Journal of the National Cancer Institute. Monographs
JID - 9011255
SB  - IM
MH  - Biomedical Research/*methods
MH  - Humans
MH  - National Cancer Institute (U.S.)
MH  - Neoplasms/genetics/*metabolism/pathology
MH  - Specimen Handling/methods/standards
MH  - Tissue Banks/*organization & administration/*standards
MH  - United States
EDAT- 2011/06/16 06:00
MHDA- 2011/10/05 06:00
CRDT- 2011/06/16 06:00
PHST- 2011/06/16 06:00 [entrez]
PHST- 2011/06/16 06:00 [pubmed]
PHST- 2011/10/05 06:00 [medline]
AID - lgr006 [pii]
AID - 10.1093/jncimonographs/lgr006 [doi]
PST - ppublish
SO  - J Natl Cancer Inst Monogr. 2011;2011(42):1-7. doi: 10.1093/jncimonographs/lgr006.


PMID- 21672697
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20190902
IS  - 0317-1671 (Print)
IS  - 0317-1671 (Linking)
VI  - 38
IP  - 4
DP  - 2011 Jul
TI  - A canadian perspective on ethics review and neuroimaging: tensions and solutions.
PG  - 572-9
AB  - Neuroimaging research has raised ethical concerns such as the management of
      unexpected findings and the classification and assessment of risks. Research
      ethics boards (REBs) bear responsibility for the oversight of these challenges
      but neuroimagers struggle with the practical aspects of ethics review and report 
      that administrative load and inconsistency contribute to eroding confidence and
      trust in ethics review. Our goal was to discuss and propose strategies for
      institutional and educational change to improve ethics review. We used an
      iterative and deliberative workshop-based writing process involving multiple
      disciplines. We propose recommendations in three tension areas: (1) communication
      between researchers and REBs; (2) collaboration and sharing of expertise between 
      REBs; and (3) practical considerations and the needs of neuroimagers engaged in
      the ethics review process. Our recommendations are intended as openings rather
      than endpoints. Researchers and research ethics governance communities should
      decide on the future uptake of these recommendations.
FAU - Racine, Eric
AU  - Racine E
AD  - Neuroethics Research Unit, Institut de recherches cliniques de Montreal
      Biomedical Ethics Unit, McGill University Division of Experimental Medicine,
      McGill University Department of Neurology/Neurosurgery, McGill University
      Departments of Medicine and Social and Preventive Medicine, Bioethics Programs,
      University of Montreal, Montreal, Quebec.
FAU - Northoff, Georg
AU  - Northoff G
FAU - Menon, Ravi S
AU  - Menon RS
FAU - Kimmelman, Jonathan
AU  - Kimmelman J
FAU - Illes, Judy
AU  - Illes J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Can J Neurol Sci
JT  - The Canadian journal of neurological sciences. Le journal canadien des sciences
      neurologiques
JID - 0415227
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Canada
MH  - Diagnostic Imaging/*ethics/standards
MH  - Humans
MH  - Incidental Findings
MH  - *Peer Review, Research/methods/standards
EDAT- 2011/06/16 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/06/16 06:00
PHST- 2011/06/16 06:00 [entrez]
PHST- 2011/06/16 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 60K78Q9R25454642 [pii]
AID - 10.1017/s0317167100012117 [doi]
PST - ppublish
SO  - Can J Neurol Sci. 2011 Jul;38(4):572-9. doi: 10.1017/s0317167100012117.


PMID- 21672482
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1920-1214 (Electronic)
IS  - 1911-6470 (Linking)
VI  - 5
IP  - 3
DP  - 2011 Jun
TI  - Novel method of knotless vesicourethral anastomosis during robot-assisted radical
      prostatectomy: feasibility study and early outcomes in 30 patients using the
      interlocked barbed unidirectional V-LOC180 suture.
PG  - 188-94
LID - 10.5489/cuaj.10194 [doi]
AB  - PURPOSE: : Our purpose was to describe the safety and feasibility of a running
      posterior reconstruction (PR) integrated with continuous vesicourethral
      anastomosis (VUA) using a novel self-cinching unidirectional barbed suture in
      robot-assisted radical prostatectomy (RARP). METHODS: : Between March and October
      2010, 30 consecutive patients with organ-confined prostate cancer underwent RARP 
      by an experienced single surgeon (KCZ). Upon completion of radical prostatectomy,
      urinary reconstruction was carried out using 2 knotless, interlocked 6-inches 3-0
      V-Loc-180 suture. The left tail of the suture was initially used for PR (starting
      at 5-o'clock and ran to re-approximate the retrotrigonal layer to the
      rectourethralis) followed by left-sided VUA (from 6- to 12-o'clock), while the
      right-sided suture completed the right-sided VUA. Assurance of watertight closure
      with an intraoperative 300 cc saline visual cystogram was performed in all cases 
      prior to case completion. Perioperative outcomes and 30-day complications were
      recorded. RESULTS: : All anastamoses were performed without assistance and
      without knot tying. Median time for nurse setup and urinary reconstruction was 40
      seconds (interquartile range [IQR] 25-60) and 14.6 min (IQR 10-18), respectively.
      The need to readjust suture tension or place Lapra-Ty clips (Ethicon
      Endo-Surgery, Cincinnati, OH) to establish watertight closure was observed in 2
      cases (7%). No patient had clinical urinary leak and there was no urinary
      retention after catheter removal on mean postoperative day 5 (IQR 4-6).
      CONCLUSIONS: : Our clinical experience with a novel technique using the
      interlocked V-Loc suture during RARP for both PR and anastomosis appears to be
      safe and efficient. Using the barbed suture prevents slippage and eliminates the 
      need for bedside assistance to maintain suture tension or knot tying, thus
      assuring watertight tissue closure.
FAU - Zorn, Kevin C
AU  - Zorn KC
AD  - Section of Urology, Department of Surgery, University of Montreal, Sacre-Coeur de
      Montreal Hospital, Montreal, QC.
FAU - Widmer, Hugues
AU  - Widmer H
FAU - Lattouf, Jean-Baptiste
AU  - Lattouf JB
FAU - Liberman, Dan
AU  - Liberman D
FAU - Bhojani, Naeem
AU  - Bhojani N
FAU - Trinh, Quoc-Dien
AU  - Trinh QD
FAU - Sun, Maxine
AU  - Sun M
FAU - Karakiewicz, Pierre I
AU  - Karakiewicz PI
FAU - Denis, Ronald
AU  - Denis R
FAU - El-Hakim, Assaad
AU  - El-Hakim A
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Urol Assoc J
JT  - Canadian Urological Association journal = Journal de l'Association des urologues 
      du Canada
JID - 101312644
PMC - PMC3114030
EDAT- 2011/06/16 06:00
MHDA- 2011/06/16 06:01
CRDT- 2011/06/16 06:00
PHST- 2011/06/16 06:00 [entrez]
PHST- 2011/06/16 06:00 [pubmed]
PHST- 2011/06/16 06:01 [medline]
AID - cuaj.10194 [pii]
AID - 10.5489/cuaj.10194 [doi]
PST - ppublish
SO  - Can Urol Assoc J. 2011 Jun;5(3):188-94. doi: 10.5489/cuaj.10194.


PMID- 21672454
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20110615
IS  - 1646-0758 (Electronic)
IS  - 0870-399X (Linking)
VI  - 24
IP  - 1
DP  - 2011 Jan-Feb
TI  - [System of biometric identification: by the way of control].
PG  - 163-8
AB  - The ethics and morals make the line between lawful to unlawful, the right and
      wrong, acceptable from the unacceptable. Furthermore the purpose of ethics in the
      field of profesional practice is, in particular the application of moral
      standards based on honesty, courtesy and honour. But they are not the only ones. 
      Confidentiality should be the first of duties the professional has no right to
      disclose information that was only reported in their work and because it was
      necessary to run it. This requirement aims to protect the recipient of the
      service and avoid damage to society. The professional should also encourage
      members of his team, because solidarity is a very effective way to improve the
      intellectual and moral qualities of work partners and ensure their involvement.
      When you have an honest professional conduct within and outside of professional
      practice, you attract confidence and prestige, which is an incentive to drive,
      with safety, the proper course of his career. The purpose of the biometric
      control based on the need to expedite the fulfilment of a goal whose integration 
      is recognized by law under the control of the employer's: the setting of working 
      hours, monitoring the attendance and registration of working time. This record is
      also the accounting and control of additional work. To consider the biometric
      control as an appropriate mean to ensure a <<legitimate purpose>>, the Law 67/98 
      requires the National Commission for Data Protection, in each case, to ascertain 
      whether the prevailing interests the rights and freedoms guarantees data subjects
      on the interest for the treatment of data relied upon by the employer. This
      procedure seems to be the best fit to the principle of proportionality and
      therefore the processing of data should be refused where it appears unjustified, 
      inappropriate and excessive, or when, by their lack of reliability, it undermines
      the purpose of determining it.
FAU - Simoes, Jose Augusto
AU  - Simoes JA
AD  - Unidade de Saude Familiar Marques de Marialva, Cantanhede, Escola Superior de
      Saude da Universidade de Aveiro, Portugal.
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Sistemas de identificacao biometrica: a proposito do controlo.
DEP - 20110228
PL  - Portugal
TA  - Acta Med Port
JT  - Acta medica portuguesa
JID - 7906803
SB  - IM
MH  - Biometric Identification/*ethics
MH  - Humans
EDAT- 2011/06/16 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/06/16 06:00
PHST- 2009/02/09 00:00 [received]
PHST- 2009/03/10 00:00 [accepted]
PHST- 2011/06/16 06:00 [entrez]
PHST- 2011/06/16 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
PST - ppublish
SO  - Acta Med Port. 2011 Jan-Feb;24(1):163-8. Epub 2011 Feb 28.


PMID- 21672217
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20211020
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 12
DP  - 2011 Jun 14
TI  - Effectiveness, relapse prevention and mechanisms of change of cognitive therapy
      vs. interpersonal therapy for depression: Study protocol for a randomised
      controlled trial.
PG  - 150
LID - 10.1186/1745-6215-12-150 [doi]
AB  - BACKGROUND: Major depression is a common mental disorder that substantially
      impairs quality of life and has high societal costs. Although psychotherapies
      have proven to be effective antidepressant treatments, initial response rates are
      insufficient and the risk of relapse and recurrence is high. Improvement of
      treatments is badly needed. Studying the mechanisms of change in treatment might 
      be a good investment for improving everyday mental health care. However, the
      mechanisms underlying therapeutic change remain largely unknown. The objective of
      the current study is to assess both the effectiveness of two commonly used
      psychotherapies for depression in terms of reduction of symptoms and prevention
      of relapse on short and long term, as well as identifying underlying mechanisms
      of change. METHODS: In a randomised trial we will compare (a) Cognitive Therapy
      (CT) with (b) Interpersonal therapy (IPT), and (c) an 8-week waiting list
      condition followed by treatment of choice. One hundred eighty depressed patients 
      (aged 18-65) will be recruited in a mental health care centre in Maastricht (the 
      Netherlands). Eligible patients will be randomly allocated to one of the three
      intervention groups. The primary outcome measure of the clinical evaluation is
      depression severity measured by the Beck Depression Intenvory-II (BDI-II). Other 
      outcomes include process variables such as dysfunctional beliefs, negative
      attributions, and interpersonal problems. All self-report outcome assessments
      will take place on the internet at baseline, three, seven, eight, nine, ten,
      eleven, twelve and twenty-four months. At 24 months a retrospective telephone
      interview will be administered. Furthermore, a rudimentary analysis of the
      cost-effectiveness will be embedded. The study has been ethically approved and
      registered. DISCUSSION: By comparing CT and IPT head-to-head and by investigating
      multiple potential mediators and outcomes at multiple time points during and
      after therapy, we hope to provide new insights in the effectiveness and
      mechanisms of change of CT and IPT for depression, and contribute to the
      improvement of mental health care for adults suffering from depression. TRIAL
      REGISTRATION: The study has been registered at the Netherlands Trial Register,
      part of the Dutch Cochrane Centre (ISRCTN67561918).
FAU - Lemmens, Lotte H J M
AU  - Lemmens LH
AD  - Department of Clinical Psychological Science, Faculty of Psychology and
      Neuroscience, Maastricht University, the Netherlands.
      lotte.lemmens@maastrichtuniversity.nl
FAU - Arntz, Arnoud
AU  - Arntz A
FAU - Peeters, Frenk P M L
AU  - Peeters FP
FAU - Hollon, Steven D
AU  - Hollon SD
FAU - Roefs, Anne
AU  - Roefs A
FAU - Huibers, Marcus J H
AU  - Huibers MJ
LA  - eng
SI  - ISRCTN/ISRCTN67561918
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110614
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Cognitive Behavioral Therapy/economics
MH  - Cost-Benefit Analysis
MH  - Depressive Disorder, Major/diagnosis/economics/psychology/*therapy
MH  - Health Care Costs
MH  - Humans
MH  - *Interpersonal Relations
MH  - Interviews as Topic
MH  - Middle Aged
MH  - Netherlands
MH  - Psychiatric Status Rating Scales
MH  - *Research Design
MH  - Secondary Prevention
MH  - Surveys and Questionnaires
MH  - Telephone
MH  - Time Factors
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC3136406
EDAT- 2011/06/16 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/06/16 06:00
PHST- 2011/04/29 00:00 [received]
PHST- 2011/06/14 00:00 [accepted]
PHST- 2011/06/16 06:00 [entrez]
PHST- 2011/06/16 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - 1745-6215-12-150 [pii]
AID - 10.1186/1745-6215-12-150 [doi]
PST - epublish
SO  - Trials. 2011 Jun 14;12:150. doi: 10.1186/1745-6215-12-150.


PMID- 21672210
OWN - NLM
STAT- MEDLINE
DCOM- 20110921
LR  - 20211020
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 12
DP  - 2011 Jun 14
TI  - Personal genome testing: test characteristics to clarify the discourse on
      ethical, legal and societal issues.
PG  - 11
LID - 10.1186/1472-6939-12-11 [doi]
AB  - BACKGROUND: As genetics technology proceeds, practices of genetic testing have
      become more heterogeneous: many different types of tests are finding their way to
      the public in different settings and for a variety of purposes. This
      diversification is relevant to the discourse on ethical, legal and societal
      issues (ELSI) surrounding genetic testing, which must evolve to encompass these
      differences. One important development is the rise of personal genome testing on 
      the basis of genetic profiling: the testing of multiple genetic variants
      simultaneously for the prediction of common multifactorial diseases. Currently,
      an increasing number of companies are offering personal genome tests directly to 
      consumers and are spurring ELSI-discussions, which stand in need of
      clarification. This paper presents a systematic approach to the ELSI-evaluation
      of personal genome testing for multifactorial diseases along the lines of its
      test characteristics. DISCUSSION: This paper addresses four test characteristics 
      of personal genome testing: its being a non-targeted type of testing, its high
      analytical validity, low clinical validity and problematic clinical utility.
      These characteristics raise their own specific ELSI, for example: non-targeted
      genetic profiling poses serious problems for information provision and informed
      consent. Questions about the quantity and quality of the necessary information,
      as well as about moral responsibilities with regard to the provision of
      information are therefore becoming central themes within ELSI-discussions of
      personal genome testing. Further, the current low level of clinical validity of
      genetic profiles raises questions concerning societal risks and regulatory
      requirements, whereas simultaneously it causes traditional ELSI-issues of
      clinical genetics, such as psychological and health risks, discrimination, and
      stigmatization, to lose part of their relevance. Also, classic notions of
      clinical utility are challenged by the newer notion of 'personal utility.'
      SUMMARY: Consideration of test characteristics is essential to any valuable
      discourse on the ELSI of personal genome testing for multifactorial diseases.
      Four key characteristics of the test - targeted/non-targeted testing, analytical 
      validity, clinical validity and clinical utility - together determine the
      applicability and the relevance of ELSI to specific tests. The paper identifies
      and discusses four areas of interest for the ELSI-debate on personal genome
      testing: informational problems, risks, regulatory issues, and the notion of
      personal utility.
FAU - Bunnik, Eline M
AU  - Bunnik EM
AD  - Department of Medical Ethics and Philosophy of Medicine, Erasmus University
      Medical Center, Rotterdam, The Netherlands.
FAU - Schermer, Maartje H N
AU  - Schermer MH
FAU - Janssens, A Cecile J W
AU  - Janssens AC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110614
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Counseling
MH  - Decision Making
MH  - Genetic Testing/*ethics/*legislation & jurisprudence/standards/trends
MH  - Genome, Human
MH  - Health Policy
MH  - Humans
MH  - Incidental Findings
MH  - Informed Consent
MH  - Predictive Value of Tests
MH  - Reproducibility of Results
MH  - Risk Assessment
MH  - Stereotyping
PMC - PMC3141793
EDAT- 2011/06/16 06:00
MHDA- 2011/09/22 06:00
CRDT- 2011/06/16 06:00
PHST- 2011/02/25 00:00 [received]
PHST- 2011/06/14 00:00 [accepted]
PHST- 2011/06/16 06:00 [entrez]
PHST- 2011/06/16 06:00 [pubmed]
PHST- 2011/09/22 06:00 [medline]
AID - 1472-6939-12-11 [pii]
AID - 10.1186/1472-6939-12-11 [doi]
PST - epublish
SO  - BMC Med Ethics. 2011 Jun 14;12:11. doi: 10.1186/1472-6939-12-11.


PMID- 21671807
OWN - NLM
STAT- MEDLINE
DCOM- 20111109
LR  - 20111122
IS  - 1943-569X (Electronic)
IS  - 0003-1488 (Linking)
VI  - 238
IP  - 12
DP  - 2011 Jun 15
TI  - Ethical considerations raised by the provision of freebies to veterinary
      students.
PG  - 1551-4
LID - 10.2460/javma.238.12.1551 [doi]
FAU - Dally, Michelle
AU  - Dally M
AD  - College of Veterinary Medicine and Biomedical Sciences. Colorado State
      University, Fort Collins, CO 80523, USA. mdally@colostate.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Vet Med Assoc
JT  - Journal of the American Veterinary Medical Association
JID - 7503067
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
CIN - J Am Vet Med Assoc. 2011 Aug 1;239(3):298. PMID: 21916051
CIN - J Am Vet Med Assoc. 2011 Aug 15;239(4):429. PMID: 21938880
CIN - J Am Vet Med Assoc. 2011 Nov 1;239(9):1179. PMID: 21999787
CIN - J Am Vet Med Assoc. 2011 Aug 15;239(4):429. PMID: 22125821
MH  - Animal Feed
MH  - Conflict of Interest
MH  - Drug Industry/*ethics
MH  - *Education, Veterinary
MH  - Pharmaceutical Preparations
MH  - Physicians/psychology
MH  - *Students
MH  - Veterinarians/psychology
MH  - Veterinary Medicine/*ethics
EDAT- 2011/06/16 06:00
MHDA- 2011/11/10 06:00
CRDT- 2011/06/16 06:00
PHST- 2011/06/16 06:00 [entrez]
PHST- 2011/06/16 06:00 [pubmed]
PHST- 2011/11/10 06:00 [medline]
AID - 10.2460/javma.238.12.1551 [doi]
PST - ppublish
SO  - J Am Vet Med Assoc. 2011 Jun 15;238(12):1551-4. doi: 10.2460/javma.238.12.1551.


PMID- 21671399
OWN - NLM
STAT- MEDLINE
DCOM- 20111014
LR  - 20200930
IS  - 1552-4833 (Electronic)
IS  - 1552-4825 (Linking)
VI  - 155A
IP  - 7
DP  - 2011 Jul
TI  - Trisomy 18: experience of a reference hospital from the south of Brazil.
PG  - 1529-35
LID - 10.1002/ajmg.a.34088 [doi]
AB  - Trisomy 18 is a chromosomal syndrome characterized by a broad clinical picture,
      as well as a very reserved prognosis. The aim of our study was to verify the
      clinical characteristics and survival of patients diagnosed in a referral
      hospital in southern Brazil. Our sample consisted of 31 patients, 22 were female 
      (71%), ages ranging from 1 to 1,395 days (median 14 days). The majority had a
      single cell lineage with full trisomy of chromosome 18 (94%). Concerning
      pregnancy complications, pre-eclampsia was the main abnormality described (17%). 
      Fetal ultrasound was performed in 23 cases, and the most frequent abnormalities
      were polyhydramnios (41%) and intrauterine growth retardation (27%). There were
      no reports of prenatal identification of the syndrome. Most patients were born by
      cesarean due to pregnancy and fetal complications and about half of the cases
      were premature. Congenital heart defects represented the main major malformation 
      observed (94%). Thirty patients (97%) progressed to death (survival ranged from 2
      to 780 days, and 87% died within the first 6 months of life). Trisomy 18 is a
      serious chromosomal disorder with limited survival. Abnormalities of pregnancy
      appear to be frequent, which can lead to complications for both fetus and mother.
      The prenatal identification of these patients in our country is still inadequate,
      resulting in important implications for genetic counseling and management of
      these patients and their families. And this makes the possibility of interruption
      of pregnancy, regardless of ethical factors involved, an unlikely option.
CI  - Copyright (c) 2011 Wiley-Liss, Inc.
FAU - Rosa, Rafael F M
AU  - Rosa RF
AD  - Graduate Program in Pathology, Universidade Federal de Ciencias da Saude de Porto
      Alegre, RS, Brazil.
FAU - Rosa, Rosana C M
AU  - Rosa RC
FAU - Lorenzen, Marina B
AU  - Lorenzen MB
FAU - de Moraes, Felipe N
AU  - de Moraes FN
FAU - Graziadio, Carla
AU  - Graziadio C
FAU - Zen, Paulo R G
AU  - Zen PR
FAU - Paskulin, Giorgio A
AU  - Paskulin GA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110610
PL  - United States
TA  - Am J Med Genet A
JT  - American journal of medical genetics. Part A
JID - 101235741
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brazil
MH  - Child
MH  - Child, Preschool
MH  - Chromosome Aberrations/statistics & numerical data
MH  - Chromosomes, Human, Pair 18/*genetics
MH  - Female
MH  - Hospitals
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Kaplan-Meier Estimate
MH  - Karyotyping
MH  - Male
MH  - Middle Aged
MH  - Phenotype
MH  - Pregnancy
MH  - Pregnancy Complications
MH  - Prenatal Diagnosis
MH  - Sex Factors
MH  - Time Factors
MH  - Trisomy/diagnosis/*pathology
MH  - Young Adult
EDAT- 2011/06/15 06:00
MHDA- 2011/10/15 06:00
CRDT- 2011/06/15 06:00
PHST- 2011/02/07 00:00 [received]
PHST- 2011/04/06 00:00 [accepted]
PHST- 2011/06/15 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2011/10/15 06:00 [medline]
AID - 10.1002/ajmg.a.34088 [doi]
PST - ppublish
SO  - Am J Med Genet A. 2011 Jul;155A(7):1529-35. doi: 10.1002/ajmg.a.34088. Epub 2011 
      Jun 10.


PMID- 21671303
OWN - NLM
STAT- MEDLINE
DCOM- 20111214
LR  - 20110810
IS  - 1099-1050 (Electronic)
IS  - 1057-9230 (Linking)
VI  - 20
IP  - 9
DP  - 2011 Sep
TI  - The choice of detecting Down syndrome: does money matter?
PG  - 1073-89
LID - 10.1002/hec.1762 [doi]
AB  - The prenatal diagnosis of Down syndrome (amniocentesis) presents parents with a
      complex dilemma which requires comparing the risk of giving birth to an affected 
      child and the risk of losing an unaffected child through amniocentesis-related
      miscarriage. Building on the specific features of the French Health insurance
      system, this paper shows that variation in the monetary costs of the diagnosis
      procedure may have a very significant impact on how parents solve this ethical
      dilemma. The French institutions make it possible to compare otherwise similar
      women facing very different reimbursement schemes and we find that eligibility to
      full reimbursement has a largely positive effect on the probability of taking an 
      amniocentesis test. By contrast, the sole fact of being labelled 'high-risk' by
      the Health system seems to have, as such, only a modest effect on subsequent
      choices. Finally, building on available information on post-amniocentesis
      outcomes, we report new evidence suggesting that amniocentesis increases the risk
      of premature birth and low weight at birth.
CI  - Copyright (c) 2011 John Wiley & Sons, Ltd.
FAU - Garrouste, Clementine
AU  - Garrouste C
AD  - Paris School of Economics (PSE), Paris, France. clementine.garrouste@gmail.com
FAU - Le, Jerome
AU  - Le J
FAU - Maurin, Eric
AU  - Maurin E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110613
PL  - England
TA  - Health Econ
JT  - Health economics
JID - 9306780
RN  - 0 (Chorionic Gonadotropin, beta Subunit, Human)
SB  - IM
MH  - Abortion, Induced
MH  - Abortion, Spontaneous/etiology
MH  - Adult
MH  - Amniocentesis/adverse effects/*economics/standards
MH  - Chorionic Gonadotropin, beta Subunit, Human/blood
MH  - Decision Making
MH  - Down Syndrome/*diagnosis/economics/genetics
MH  - Female
MH  - France/epidemiology
MH  - Humans
MH  - Infant, Low Birth Weight
MH  - Infant, Newborn
MH  - Insurance, Health, Reimbursement/*economics/standards
MH  - Maternal Age
MH  - Pregnancy
MH  - Pregnancy Outcome/*economics/epidemiology
MH  - Premature Birth/epidemiology/etiology
MH  - Regression Analysis
MH  - Risk Assessment
EDAT- 2011/06/15 06:00
MHDA- 2011/12/15 06:00
CRDT- 2011/06/15 06:00
PHST- 2010/10/08 00:00 [received]
PHST- 2011/04/15 00:00 [revised]
PHST- 2011/05/05 00:00 [accepted]
PHST- 2011/06/15 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2011/12/15 06:00 [medline]
AID - 10.1002/hec.1762 [doi]
PST - ppublish
SO  - Health Econ. 2011 Sep;20(9):1073-89. doi: 10.1002/hec.1762. Epub 2011 Jun 13.


PMID- 21671275
OWN - NLM
STAT- MEDLINE
DCOM- 20111028
LR  - 20151119
IS  - 1554-558X (Electronic)
IS  - 0894-1912 (Linking)
VI  - 31
IP  - 2
DP  - 2011 Spring
TI  - Can criteria for identifying educational influentials in developed countries be
      applied to other countries? A study in Iran.
PG  - 95-102
LID - 10.1002/chp.20112 [doi]
AB  - INTRODUCTION: There are published criteria for identifying educational
      influentials (EIs). These criteria are based on studies that have been performed 
      in developed countries. This study was performed to identify criteria and
      characteristics of EIs in Iran. METHODS: The study was conducted on residents,
      interns, and clerks at a major educational hospital in Iran. This study had 3
      stages: (1) preparation of an inclusive list of EI characteristics through 3
      focus group discussions with 22 individuals, in which 30 primary characteristics 
      of EIs were found; (2) reducing the number of characteristics by examining 154
      individuals for exploratory factor analysis and internal consistency evaluation
      by Cronbach's alpha, after which the characteristics were reduced to 25; (3)
      finalizing the criteria through discriminant validity. RESULTS: Fifteen
      characteristics were identified in 4 domains: (1) knowledge (high level of
      clinical knowledge, being up-to-date and an expert, high level of clinical
      skills); (2) communication skills (good communication with others, easily
      accessible, good public relations, and oratory); (3) taking into account the
      stakeholders (involving patients in decision making, allowing students to
      identify problems, delivering decisions to others, and interest in transfer of
      material); and (4) professional ethics (pursuing the patients' maximum benefit,
      observing ethics in education and research). Overall, they have a sensitivity and
      specificity of 87% and 74%, respectively. DISCUSSION: Three of the four domains
      we found were already identified in other studies; however, the "taking into
      account the stakeholders" domain has not been previously reported. The other
      domains and criteria were similar to those found in developed countries.
CI  - Copyright (c) 2011 The Alliance for Continuing Medical Education, the Society for
      Academic Continuing Medical Education, and the Council on CME, Association for
      Hospital Medical Education.
FAU - Shokoohi, Mostafa
AU  - Shokoohi M
AD  - Kerman University of Medical Sciences, Tehran, Iran.
FAU - Nedjat, Saharnaz
AU  - Nedjat S
FAU - Golestan, Banafsheh
AU  - Golestan B
FAU - Soltani, Akbar
AU  - Soltani A
FAU - Majdzadeh, Reza
AU  - Majdzadeh R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Contin Educ Health Prof
JT  - The Journal of continuing education in the health professions
JID - 8805847
SB  - IM
MH  - *Clinical Clerkship
MH  - Cultural Characteristics
MH  - Discriminant Analysis
MH  - Factor Analysis, Statistical
MH  - Focus Groups
MH  - Humans
MH  - Information Dissemination/*methods
MH  - *Internship and Residency
MH  - Iran
MH  - *Mentors
MH  - Reproducibility of Results
MH  - *Sociometric Techniques
MH  - *Surveys and Questionnaires
EDAT- 2011/06/15 06:00
MHDA- 2011/10/29 06:00
CRDT- 2011/06/15 06:00
PHST- 2011/06/15 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2011/10/29 06:00 [medline]
AID - 10.1002/chp.20112 [doi]
PST - ppublish
SO  - J Contin Educ Health Prof. 2011 Spring;31(2):95-102. doi: 10.1002/chp.20112.


PMID- 21671025
OWN - NLM
STAT- MEDLINE
DCOM- 20120524
LR  - 20211020
IS  - 1573-5168 (Electronic)
IS  - 0920-1742 (Linking)
VI  - 38
IP  - 1
DP  - 2012 Feb
TI  - Does feeding time affect fish welfare?
PG  - 143-52
LID - 10.1007/s10695-011-9523-y [doi]
AB  - Increased aquaculture production has raised concerns about managing protocols to 
      safeguard the welfare of farmed fish, as consumers demand responsible aquaculture
      practices to provide 'welfare friendly' products. Feeding is one of the largest
      production cost in a fish farm and can be one of the biggest stressors for fish. 
      Under farming conditions, fish are challenged with artificial diets and feeding
      regimes, and inadequate feeding conditions cause stress, alteration of normal
      behavioural patterns, poor performance and eventually diseases and death, which
      are by no means acceptable neither economically nor ethically. This review aims
      to highlight the impact of feeding rhythms and feeding time upon physiological
      and behavioural welfare indicators, which show circadian rhythms as well.
      Therefore, all these variables should be considered when designing feeding
      strategies in farming conditions and assessing the welfare state of cultured
      fish.
FAU - Lopez-Olmeda, J F
AU  - Lopez-Olmeda JF
AD  - Department of Physiology, Faculty of Biology, University of Murcia, Murcia,
      Spain.
FAU - Noble, C
AU  - Noble C
FAU - Sanchez-Vazquez, F J
AU  - Sanchez-Vazquez FJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110614
PL  - Netherlands
TA  - Fish Physiol Biochem
JT  - Fish physiology and biochemistry
JID - 100955049
SB  - IM
MH  - *Animal Welfare
MH  - Animals
MH  - Behavior, Animal/physiology
MH  - Circadian Rhythm
MH  - Feeding Methods/psychology/*veterinary
MH  - Fisheries/*standards
MH  - Fishes/growth & development/*physiology
MH  - Stress, Physiological
EDAT- 2011/06/15 06:00
MHDA- 2012/05/25 06:00
CRDT- 2011/06/15 06:00
PHST- 2010/10/21 00:00 [received]
PHST- 2011/06/03 00:00 [accepted]
PHST- 2011/06/15 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2012/05/25 06:00 [medline]
AID - 10.1007/s10695-011-9523-y [doi]
PST - ppublish
SO  - Fish Physiol Biochem. 2012 Feb;38(1):143-52. doi: 10.1007/s10695-011-9523-y. Epub
      2011 Jun 14.


PMID- 21670501
OWN - NLM
STAT- MEDLINE
DCOM- 20111013
LR  - 20211020
IS  - 1558-8238 (Electronic)
IS  - 0021-9738 (Linking)
VI  - 121
IP  - 7
DP  - 2011 Jul
TI  - Engraftment of human nasal olfactory stem cells restores neuroplasticity in mice 
      with hippocampal lesions.
PG  - 2808-20
LID - 10.1172/JCI44489 [doi]
LID - 44489 [pii]
AB  - Stem cell-based therapy has been proposed as a potential means of treatment for a
      variety of brain disorders. Because ethical and technical issues have so far
      limited the clinical translation of research using embryonic/fetal cells and
      neural tissue, respectively, the search for alternative sources of therapeutic
      stem cells remains ongoing. Here, we report that upon transplantation into mice
      with chemically induced hippocampal lesions, human olfactory ecto-mesenchymal
      stem cells (OE-MSCs) - adult stem cells from human nasal olfactory lamina propria
      - migrated toward the sites of neural damage, where they differentiated into
      neurons. Additionally, transplanted OE-MSCs stimulated endogenous neurogenesis,
      restored synaptic transmission, and enhanced long-term potentiation. Mice that
      received transplanted OE-MSCs exhibited restoration of learning and memory on
      behavioral tests compared with lesioned, nontransplanted control mice. Similar
      results were obtained when OE-MSCs were injected into the cerebrospinal fluid.
      These data show that OE-MSCs can induce neurogenesis and contribute to
      restoration of hippocampal neuronal networks via trophic actions. They provide
      evidence that human olfactory tissue is a conceivable source of nervous system
      replacement cells. This stem cell subtype may be useful for a broad range of stem
      cell-related studies.
FAU - Nivet, Emmanuel
AU  - Nivet E
AD  - Laboratoire de Neurobiologie des Processus Mnesiques, CNRS UMR-6149,
      Aix-Marseille Universite; IFR Sciences du Cerveau et de Cognition, Marseille,
      France. enivet@salk.edu
FAU - Vignes, Michel
AU  - Vignes M
FAU - Girard, Stephane D
AU  - Girard SD
FAU - Pierrisnard, Caroline
AU  - Pierrisnard C
FAU - Baril, Nathalie
AU  - Baril N
FAU - Deveze, Arnaud
AU  - Deveze A
FAU - Magnan, Jacques
AU  - Magnan J
FAU - Lante, Fabien
AU  - Lante F
FAU - Khrestchatisky, Michel
AU  - Khrestchatisky M
FAU - Feron, Francois
AU  - Feron F
FAU - Roman, Francois S
AU  - Roman FS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110613
PL  - United States
TA  - J Clin Invest
JT  - The Journal of clinical investigation
JID - 7802877
SB  - IM
MH  - Adult
MH  - Adult Stem Cells/cytology/*physiology
MH  - Animals
MH  - Behavior, Animal/physiology
MH  - Cell Differentiation/physiology
MH  - Cell Movement
MH  - Cells, Cultured
MH  - Coculture Techniques
MH  - Hippocampus/cytology/*pathology/physiology
MH  - Humans
MH  - Learning/physiology
MH  - Male
MH  - Memory/physiology
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Mesenchymal Stem Cells/cytology/*physiology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Neurogenesis/physiology
MH  - Neuronal Plasticity/*physiology
MH  - Olfactory Mucosa/*cytology
MH  - Synaptic Transmission/physiology
PMC - PMC3223823
EDAT- 2011/06/15 06:00
MHDA- 2011/10/14 06:00
CRDT- 2011/06/15 06:00
PHST- 2010/07/24 00:00 [received]
PHST- 2011/04/27 00:00 [accepted]
PHST- 2011/06/15 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2011/10/14 06:00 [medline]
AID - 44489 [pii]
AID - 10.1172/JCI44489 [doi]
PST - ppublish
SO  - J Clin Invest. 2011 Jul;121(7):2808-20. doi: 10.1172/JCI44489. Epub 2011 Jun 13.


PMID- 21670466
OWN - NLM
STAT- MEDLINE
DCOM- 20111018
LR  - 20220409
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Linking)
VI  - 118
IP  - 6
DP  - 2011 Aug 11
TI  - How I treat Gaucher disease.
PG  - 1463-71
LID - 10.1182/blood-2011-04-308890 [doi]
AB  - This review presents a cohesive approach to treating patients with Gaucher
      disease. The spectrum of the clinical presentation of the disease is broad, yet
      heretofore there was only one disease-specific treatment. In the past 2 years, a 
      global shortage of this product has resulted in reassessment of the "one
      enzyme-one disease-one therapy" mantra. It has also showcased the multiple levels
      that engage the patient, the treating physician, and the third-party insurer in
      providing adequate treatment to all symptomatic patients. The key points
      summarizing the way I manage my patients include accurate enzymatic diagnosis
      with mutation analysis (for some prognostication and better carrier detection in 
      the family), a detailed follow-up every 6-12 months (with an option to see
      consultants and attention to comorbidities), and initiation of enzyme replacement
      therapy according to symptoms or deterioration in clinically significant features
      or both. I do not treat patients with very mild disease, but I consider
      presymptomatic therapy for patients at risk, including young women with poor
      obstetric history. I prefer the minimal-effective dose rather than the maximally 
      tolerated dose, and when the difference between high-dose and lower-dose regimens
      is (merely statistically significant but) clinically meaningless, minimizing the 
      burden on society by advocating less-expensive treatments is ethically justified.
FAU - Zimran, Ari
AU  - Zimran A
AD  - Gaucher Clinic, Shaare Zedek Medical Center, Hebrew University-Hadassah Medical
      School, Jerusalem, Israel. azimran@gmail.com
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110613
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - EC 3.2.1.45 (Glucosylceramidase)
SB  - IM
MH  - DNA Mutational Analysis
MH  - Enzyme Replacement Therapy/*methods
MH  - Follow-Up Studies
MH  - Gaucher Disease/*diagnosis/*drug therapy/genetics
MH  - Genetic Counseling
MH  - Genotype
MH  - Glucosylceramidase/genetics/metabolism/*therapeutic use
MH  - Humans
MH  - Mutation
EDAT- 2011/06/15 06:00
MHDA- 2011/10/19 06:00
CRDT- 2011/06/15 06:00
PHST- 2011/06/15 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2011/10/19 06:00 [medline]
AID - S0006-4971(20)40776-1 [pii]
AID - 10.1182/blood-2011-04-308890 [doi]
PST - ppublish
SO  - Blood. 2011 Aug 11;118(6):1463-71. doi: 10.1182/blood-2011-04-308890. Epub 2011
      Jun 13.


PMID- 21670320
OWN - NLM
STAT- MEDLINE
DCOM- 20120312
LR  - 20161125
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 12
DP  - 2011 Dec
TI  - Lost property? Legal compensation for destroyed sperm: a reflection and
      comparison drawing on UK and French perspectives.
PG  - 747-51
LID - 10.1136/jme.2010.042036 [doi]
AB  - In a recent case in the UK, six men stored their sperm before undergoing
      chemotherapy treatment for cancer in case they proved to be infertile after the
      treatment. The sperm was not properly stored and as a result was inadvertently
      destroyed. The men sued the NHS Trust that stored the sperm and were in the end
      successful. This paper questions the basis on which the judgement was made and
      the rationale behind it, namely that the men 'had ownership' of the sperm, and
      that compensation was thus due on the grounds that the men's property had been
      destroyed. We first argue that the claim is erroneous and enhances the tendency
      towards the commodification of body parts. We then suggest that the men could
      have been compensated for the harm done to them without granting property rights,
      and that this would, at least in philosophical and ethical terms, have been more 
      appropriate. To help illustrate this, we draw on a parallel case in French law in
      which a couple whose embryos had been destroyed were overtly denied ownership
      rights in them. Finally, we suggest some possible ethical and practical problems 
      if the proprietary view expressed in the UK ruling were to become dominant in
      law, with particular focus on the storing of genetic information in biobanks. We 
      conclude that, although compensation claims should not necessarily be ruled out, 
      a 'no property in the body' approach should be the default position in cases of
      detached bodily materials, the alternative being significantly ethically
      problematic.
FAU - Cordell, Sean
AU  - Cordell S
AD  - Department of Philosophy, School of Philosophy, Theology & Religion, University
      of Birmingham, Birmingham, UK. sean.68@live.com
FAU - Bellivier, Florence
AU  - Bellivier F
FAU - Widdows, Heather
AU  - Widdows H
FAU - Noiville, Christine
AU  - Noiville C
LA  - eng
PT  - Journal Article
DEP - 20110613
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Commodification
MH  - Compensation and Redress/*ethics
MH  - Ethics, Medical
MH  - France
MH  - Human Body
MH  - Human Rights
MH  - Humans
MH  - Infertility, Male/chemically induced
MH  - Male
MH  - Malpractice/legislation & jurisprudence
MH  - Morals
MH  - Ownership/ethics/legislation & jurisprudence
MH  - Sperm Banks/*legislation & jurisprudence/standards
MH  - Spermatozoa
MH  - State Medicine
MH  - United Kingdom
EDAT- 2011/06/15 06:00
MHDA- 2012/03/13 06:00
CRDT- 2011/06/15 06:00
PHST- 2011/06/15 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2012/03/13 06:00 [medline]
AID - jme.2010.042036 [pii]
AID - 10.1136/jme.2010.042036 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Dec;37(12):747-51. doi: 10.1136/jme.2010.042036. Epub 2011 Jun
      13.


PMID- 21670319
OWN - NLM
STAT- MEDLINE
DCOM- 20120312
LR  - 20151119
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 12
DP  - 2011 Dec
TI  - Obstetrician-gynaecologists' opinions about conscientious refusal of a request
      for abortion: results from a national vignette experiment.
PG  - 711-4
LID - 10.1136/jme.2010.040782 [doi]
AB  - BACKGROUND AND OBJECTIVES: Conscientious refusal of abortion has been discussed
      widely by medical ethicists but little information on practitioners' opinions
      exists. The American College of Obstetricians and Gynecologists (ACOG) issued
      recommendations about conscientious refusal. We used a vignette experiment to
      examine obstetrician-gynecologists' (OB/GYN) support for the recommendations.
      DESIGN: A national survey of OB/GYN physicians contained a vignette experiment in
      which an OB/GYN doctor refused a requested elective abortion. The vignette varied
      two issues recently addressed by the ACOG ethics committee--whether the doctor
      referred and whether the doctor disclosed their objection to the abortion.
      PARTICIPANTS AND SETTING: 1800 OB/GYN randomly selected physicians were asked to 
      complete a mail survey containing the vignette. The response rate was 66%
      (n=1154) after excluding 40 ineligible cases. MEASUREMENT: Physicians indicated
      their approval for the vignette doctor's decision. MAIN RESULTS: Overall, 43% of 
      OB/GYN physicians responded that the conscientious refusal exercised by the
      vignette physician was appropriate. 70% rated the vignette doctor as acting
      appropriately when a referral was made. This dropped to 51% when the doctor
      disclosed objections to the patient, and to 12% when the doctor disclosed
      objections and refused to make a referral. Consistent with previous research,
      males were more likely to support disclosure and refusal to refer. Highly
      religious physicians supported non-referral but not disclosure. CONCLUSION:
      OB/GYN physicians are less likely to support conscientious refusal of abortion if
      physicians disclose their objections to patients. This is at odds with ACOG
      recommendations and with some models of the doctor-patient relationship.
FAU - Rasinski, Kenneth A
AU  - Rasinski KA
AD  - Department of Medicine, The University of Chicago, 5841 South Maryland Avenue,
      Chicago, IL 60637, USA. krasinsk@medicine.bsd.uchicago.edu
FAU - Yoon, John D
AU  - Yoon JD
FAU - Kalad, Youssef G
AU  - Kalad YG
FAU - Curlin, Farr A
AU  - Curlin FA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110613
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Abortion Applicants
MH  - Adult
MH  - Aged
MH  - Attitude of Health Personnel
MH  - Ethics, Clinical
MH  - Ethics, Medical
MH  - Female
MH  - Gynecology/*ethics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obstetrics/*ethics
MH  - Physicians/*ethics
MH  - Pregnancy
MH  - Referral and Consultation/ethics
MH  - Refusal to Treat/*ethics
MH  - Research Design
MH  - Surveys and Questionnaires
EDAT- 2011/06/15 06:00
MHDA- 2012/03/13 06:00
CRDT- 2011/06/15 06:00
PHST- 2011/06/15 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2012/03/13 06:00 [medline]
AID - jme.2010.040782 [pii]
AID - 10.1136/jme.2010.040782 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Dec;37(12):711-4. doi: 10.1136/jme.2010.040782. Epub 2011 Jun 
      13.


PMID- 21668802
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20211020
IS  - 1365-2788 (Electronic)
IS  - 0964-2633 (Linking)
VI  - 55
IP  - 8
DP  - 2011 Aug
TI  - Needs and challenges of daily life for people with Down syndrome residing in the 
      city of Rome, Italy.
PG  - 801-20
LID - 10.1111/j.1365-2788.2011.01432.x [doi]
AB  - BACKGROUND: Population-based surveys on the quality of life of people with Down
      syndrome (DS) are difficult to perform because of ethical and legal policies
      regarding privacy and confidential information, but they are essential for
      service planning. Little is known about the sample size and variability of
      quality of life of people with DS living in the city of Rome, which has a
      population of 2.7 million inhabitants. The aim of the present study is to explore
      the needs and challenges in health, social integration and daily life, of people 
      with DS living in Rome. METHODOLOGY: A cross-sectional, census-based survey was
      conducted in 2006. All family doctors (3016 in total) of the National Health
      Service were involved by the Statistical Bureau of the Municipality of Rome. As
      per the census, every resident citizen is registered with a family doctor and
      every person with disabilities is coded. Associations for Down Syndrome
      encouraged their members to participate in the research. Questionnaires were
      completed by families of people with DS, in accordance with privacy laws.
      FINDINGS: An initial survey, conducted via a letter and a telephone contact with 
      family doctors, identified 884 people with DS residing in the city of Rome. Data 
      on the medical and social conditions of 518 people with DS, ranging in age from 0
      to 64 years, were collected. Some 88% of these were living with their original
      family; 82.1% had one or more siblings, and 19.5% had lost one or both parents. A
      full 100% of children with DS were enrolled in the public school system. This
      ensures that they are fully occupied and entirely integrated in society. After
      secondary school there is a lack of opportunities. Thus, only 10% of adults were 
      working with a regular contract. A mere 42.2% of people with DS aged 25-30 were
      involved in some form of regular activity (although not always on a daily basis).
      After the age of 30, the percentage of people demonstrating decline in function
      increased sharply, while disability-related support decreased. In other words, as
      people with DS age, daily life evolves increasingly around the home, with only
      occasional outdoor activities. CONCLUSION: The health, employment and social
      needs of the majority of people with DS in the city of Rome are not being met.
      The findings of this study underscore the urgent need for more comprehensive
      inclusion in society of adults with DS and for the provision of support services 
      to create an enabling environment for inclusion. Because of the variability of
      performance among individuals with DS, there is a need to create more
      case-specific options in terms of work, living arrangements, social networking
      and medical services. Schooling and social inclusion in childhood alone do not
      guarantee a satisfactory quality of life in adulthood. It is argued herewith that
      policy of inclusion and support should extend over the entire lifetime of people 
      with DS.
CI  - (c) 2011 The Authors. Journal of Intellectual Disability Research (c) 2011
      Blackwell Publishing Ltd.
FAU - Bertoli, M
AU  - Bertoli M
AD  - Genetica Medica, Ospedale San Pietro Fatebenefratelli, Roma, Italy.
FAU - Biasini, G
AU  - Biasini G
FAU - Calignano, M T
AU  - Calignano MT
FAU - Celani, G
AU  - Celani G
FAU - De Grossi, G
AU  - De Grossi G
FAU - Digilio, M C
AU  - Digilio MC
FAU - Fermariello, C C
AU  - Fermariello CC
FAU - Loffredo, G
AU  - Loffredo G
FAU - Luchino, F
AU  - Luchino F
FAU - Marchese, A
AU  - Marchese A
FAU - Mazotti, S
AU  - Mazotti S
FAU - Menghi, B
AU  - Menghi B
FAU - Razzano, C
AU  - Razzano C
FAU - Tiano, C
AU  - Tiano C
FAU - Zambon Hobart, A
AU  - Zambon Hobart A
FAU - Zampino, G
AU  - Zampino G
FAU - Zuccala, G
AU  - Zuccala G
LA  - eng
PT  - Journal Article
DEP - 20110613
PL  - England
TA  - J Intellect Disabil Res
JT  - Journal of intellectual disability research : JIDR
JID - 9206090
SB  - IM
MH  - Activities of Daily Living/*psychology
MH  - Adolescent
MH  - Adult
MH  - Age Distribution
MH  - Caregivers/statistics & numerical data
MH  - Child
MH  - Child, Preschool
MH  - Community Mental Health Services/statistics & numerical data
MH  - Cross-Sectional Studies
MH  - Down Syndrome/*psychology/*rehabilitation
MH  - Education of Intellectually Disabled/statistics & numerical data
MH  - Employment, Supported/statistics & numerical data
MH  - Female
MH  - Health Services Needs and Demand/statistics & numerical data
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Intellectual Disability/psychology/rehabilitation
MH  - Male
MH  - Middle Aged
MH  - Needs Assessment/*statistics & numerical data
MH  - Quality of Life/*psychology
MH  - Rome
MH  - Sex Distribution
MH  - Social Support
MH  - Surveys and Questionnaires
MH  - Young Adult
PMC - PMC3170479
EDAT- 2011/06/15 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/06/15 06:00
PHST- 2011/06/15 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - 10.1111/j.1365-2788.2011.01432.x [doi]
PST - ppublish
SO  - J Intellect Disabil Res. 2011 Aug;55(8):801-20. doi:
      10.1111/j.1365-2788.2011.01432.x. Epub 2011 Jun 13.


PMID- 21668620
OWN - NLM
STAT- MEDLINE
DCOM- 20110926
LR  - 20110614
IS  - 1466-769X (Electronic)
IS  - 1466-7681 (Linking)
VI  - 12
IP  - 3
DP  - 2011 Jul
TI  - Pharmaceutical industry discursives and the marketization of nursing work: a case
      example.
PG  - 214-28
LID - 10.1111/j.1466-769X.2011.00498.x [doi]
AB  - Increasing pharmaceutical industry presence in health care research and practice 
      has evoked critical social, political, economic, and ethical questions and
      concern among health care providers, ethicists, economists, and the general
      citizenry. The case example presented of the 'marketization' of nursing practice 
      not only reveals the magnitude of the purview of the pharmaceutical industry, it 
      demonstrates how that industry imparts effect upon the organization of nursing
      work, an area of health care professional practice where the ethical polemic of
      pharmaceutical industry involvement and influence has been largely ignored, and
      the profession of nursing conspicuously silent. Drawing on a Foucauldian
      dispositive analysis that troubled the complex apparatus responsible for the
      production of knowledge and action in the neurology subspecialty of multiple
      sclerosis (MS), the case discloses how the pharmaceutical industry has created
      compliance and adherence as clinical imperatives in the practice of MS nursing.
      The case makes explicit the conscious transformative self-action undertaken by MS
      nurses as a result of their subjectivation (marketization) and demonstrates how
      MS nurses have become pawns in pharmaceutical industry strategic games of power, 
      truth, identity, and wealth creation by turning their clinical practice settings 
      into heterodiscursive spaces of surveillance and persuasion. MS nurses have
      become instruments of the pharmaceutical industry, and their clinical practices
      ordered, organized, limited, constrained, and marketized as a result.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Springer, Rusla Anne
AU  - Springer RA
AD  - University of Saskatchewan, Saskatoon, Canada. ra.springer@usask.ca
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Philos
JT  - Nursing philosophy : an international journal for healthcare professionals
JID - 100897394
SB  - IM
MH  - Drug Industry/*ethics
MH  - Ethics, Nursing
MH  - Humans
MH  - Marketing of Health Services/*ethics
MH  - Morals
MH  - Multiple Sclerosis/*nursing
MH  - Nurse-Patient Relations/*ethics
MH  - Philosophy, Nursing
MH  - Professional Autonomy
EDAT- 2011/06/15 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/06/15 06:00
PHST- 2011/06/15 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 10.1111/j.1466-769X.2011.00498.x [doi]
PST - ppublish
SO  - Nurs Philos. 2011 Jul;12(3):214-28. doi: 10.1111/j.1466-769X.2011.00498.x.


PMID- 21668497
OWN - NLM
STAT- MEDLINE
DCOM- 20120103
LR  - 20161125
IS  - 1651-2227 (Electronic)
IS  - 0803-5253 (Linking)
VI  - 100
IP  - 9
DP  - 2011 Sep
TI  - Organ donation from children: time for legal, ethical and cultural change.
PG  - 1175-9
LID - 10.1111/j.1651-2227.2011.02380.x [doi]
AB  - UNLABELLED: Successful transplantation has lead to increasing need for donated
      organs from children; however, contemporaneously decreased brain-death rates
      means optimization of donation processes is crucial. Although excellent
      palliative care and organ donation are compatible, discrepancies exist both
      between and within European countries in abilities to offer families donation
      opportunities. Change will require address of legal, ethical and cultural
      barriers, and this review aims to explore such changes pertinent to both dead and
      living organ donation. CONCLUSION: We argue that across Europe it is surely time 
      for legal, ethical and cultural change to facilitate parents, families and of
      course children in having the choice of donation.
CI  - (c) 2011 The Author(s)/Acta Paediatrica (c) 2011 Foundation Acta Paediatrica.
FAU - Brierley, Joe
AU  - Brierley J
AD  - Paediatric and Neonatal Intensive Care Unit, Great Ormond Street Hospital for
      Children NHS Trust, London, UK. brierj@gosh.nhs.uk
FAU - Larcher, Vic
AU  - Larcher V
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110704
PL  - Norway
TA  - Acta Paediatr
JT  - Acta paediatrica (Oslo, Norway : 1992)
JID - 9205968
SB  - IM
CIN - Acta Paediatr. 2011 Sep;100(9):1172-4. PMID: 21635364
MH  - Brain Death
MH  - Cultural Evolution
MH  - *Culture
MH  - Death Certificates
MH  - *Decision Making
MH  - *Ethics, Medical
MH  - Humans
MH  - Living Donors
MH  - Tissue and Organ Procurement/*ethics/legislation & jurisprudence/methods
MH  - United Kingdom
EDAT- 2011/06/15 06:00
MHDA- 2012/01/04 06:00
CRDT- 2011/06/15 06:00
PHST- 2011/06/15 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2012/01/04 06:00 [medline]
AID - 10.1111/j.1651-2227.2011.02380.x [doi]
PST - ppublish
SO  - Acta Paediatr. 2011 Sep;100(9):1175-9. doi: 10.1111/j.1651-2227.2011.02380.x.
      Epub 2011 Jul 4.


PMID- 21667903
OWN - NLM
STAT- MEDLINE
DCOM- 20120315
LR  - 20110614
IS  - 1938-2367 (Electronic)
IS  - 0147-7447 (Linking)
VI  - 34
IP  - 6
DP  - 2011 Jun 14
TI  - Treatment of acute unstable distal clavicle fractures with single
      coracoclavicular suture fixation.
PG  - 172
LID - 10.3928/01477447-20110427-10 [doi]
AB  - Distal clavicular fractures are less common than fractures involving the middle
      third of the clavicle. For Neer type IIb distal clavicular unstable fractures
      associated with disruption of the coracoclavicular ligament, surgical treatment
      is indicated because of the high risk of nonunion. Various surgical methods can
      be found in the literature, but no gold standard has been established. We treated
      29 consecutive adult patients with unstable distal clavicular fracture with
      single coracoclavicular suture fixation by using single Mersilene tape (Ethicon, 
      Somerville, New Jersey) and without repair of the torn coracoclavicular ligament 
      or hardware implantation.Twenty-eight patients were followed for at least 46
      months (mean, 57.3 months). All fractures healed without further treatment, with 
      a mean time to union of 14.3 weeks. There was no major morbidity, but 2 minor
      complications occurred. One patient experienced a frozen shoulder on the treated 
      side postoperatively. After adequate rehabilitation, the symptom resolved without
      any complications at final follow-up. Another patient reported uncomfortable skin
      tenting due to subcutaneous protrusion of the suture node of the Mersilene tape. 
      After simple subcutaneous surgical removal of the node under local anesthesia,
      the discomfort resolved. Mean University of California Los Angeles shoulder
      rating score was 34 (range, 29-35). Twenty patients had excellent results and 8
      had good results. All patients resumed their previous levels of activity.
CI  - Copyright 2011, SLACK Incorporated.
FAU - Yang, Shan-Wei
AU  - Yang SW
AD  - Department of Biomedical Engineering, I-Shou University, Kaohsiung County,
      Taiwan. yangshanwei@yahoo.com.tw
FAU - Lin, Li Chun
AU  - Lin LC
FAU - Chang, Shwu Jen
AU  - Chang SJ
FAU - Kuo, Shyh Ming
AU  - Kuo SM
FAU - Hwang, Lain-Chyr
AU  - Hwang LC
LA  - eng
PT  - Journal Article
DEP - 20110614
PL  - United States
TA  - Orthopedics
JT  - Orthopedics
JID - 7806107
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Clavicle/*injuries/*surgery
MH  - Female
MH  - Fracture Fixation, Internal/*instrumentation/methods
MH  - Fractures, Bone/*surgery
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Suture Techniques/*instrumentation
MH  - *Sutures
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2011/06/15 06:00
MHDA- 2012/03/16 06:00
CRDT- 2011/06/15 06:00
PHST- 2011/06/15 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2012/03/16 06:00 [medline]
AID - 10.3928/01477447-20110427-10 [doi]
PST - epublish
SO  - Orthopedics. 2011 Jun 14;34(6):172. doi: 10.3928/01477447-20110427-10.


PMID- 21667790
OWN - NLM
STAT- MEDLINE
DCOM- 20110714
LR  - 20220318
IS  - 1536-5026 (Print)
IS  - 1536-5026 (Linking)
VI  - 32
IP  - 2
DP  - 2011 Mar-Apr
TI  - Core principles for developing global service-learning programs in nursing.
PG  - 95-101
AB  - Global service-learning enables nursing to develop its role in promoting global
      health and enabling vulnerable and marginalized global communities to develop
      their own capacity for growth and development. Global service-learning requires
      good planning that is based on sound best-practice principles. Drawing on the
      growing body of literature on service-learning, the authors outline and discuss
      seven key principles that can usefully guide global service-learning. These are: 
      are compassion, curiosity, courage, collaboration, creativity, capacity building,
      and competence. These principles can form the basis for ethically sound program
      development, offer a means of standardizing program development, and provide
      common criteria with which to evaluate a program's success.
FAU - McKinnon, Tamara H
AU  - McKinnon TH
AD  - Valley Foundation School of Nursing at San Jose State University, San Jose,
      California, USA. thm4@cruzio.com
FAU - Fealy, Gerard
AU  - Fealy G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Nurs Educ Perspect
JT  - Nursing education perspectives
JID - 101140025
MH  - Community Participation
MH  - Creativity
MH  - Cultural Competency
MH  - Humans
MH  - *International Cooperation
MH  - Program Development/*methods/standards
MH  - Transcultural Nursing/*education
MH  - United States
MH  - *Volunteers
EDAT- 2011/06/15 06:00
MHDA- 2011/07/16 06:00
CRDT- 2011/06/15 06:00
PHST- 2011/06/15 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
AID - 10.5480/1536-5026-32.2.95 [doi]
PST - ppublish
SO  - Nurs Educ Perspect. 2011 Mar-Apr;32(2):95-101. doi: 10.5480/1536-5026-32.2.95.


PMID- 21667666
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20131121
IS  - 0327-9545 (Print)
IS  - 0327-9545 (Linking)
VI  - 35
IP  - 1
DP  - 2011 Apr
TI  - Bovine parthenogenotes produced by inhibition of first or second polar bodies
      emission.
PG  - 1-7
AB  - Parthenogenetic embryos are an ethically acceptable alternative for the
      derivation of human embryonic stem cells. In this work, we propose a new strategy
      to produce bovine parthenogenetic embryos inhibiting the emission of the first
      polar body during in vitro maturation, and allowing the extrusion of the second
      polar body during oocyte activation. Cytochalasin B, an inhibitor of actin
      microfilaments, was employed during in vitro maturation to inhibit first polar
      body emission or during parthenogenetic activation to block second polar body
      emission. Only one polar body was inhibited in each strategy in order to keep the
      diploid chromosome set. In experiment 1, the effect of cytochalasin B on in vitro
      maturation of bovine oocytes was evaluated. Most oocytes (77%) were arrested at a
      meiotic stage characterized by the presence of a large internal metaphase plate
      and absence of polar body. In experiment 2, development of embryos exposed to
      cytochalasin B during in vitro maturation (CytoB-IVM) or during activation
      (CytoB-ACT) was compared. Developmental rates did not differ between
      diploidization strategies, even when three agents were employed to induce
      activation. Both groups, CytoB-IVM and CytoB-ACT, tended to maintain diploidy.
      CytoB-IVM parthenogenesis could help to obtain embryos with a higher degree of
      homology to the oocyte donor.
FAU - Bevacqua, Romina J
AU  - Bevacqua RJ
AD  - Laboratorio de Biotecnologia Animal, Facultad de Agronomia, Universidad de Buenos
      Aires. Av. San Martin 4453. C1 417DSE, Argentina.
FAU - Fernandez-Martin, Rafael
AU  - Fernandez-Martin R
FAU - Salamone, Daniel F
AU  - Salamone DF
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Biocell
JT  - Biocell : official journal of the Sociedades Latinoamericanas de Microscopia
      Electronica ... et. al
JID - 9438655
RN  - 3CHI920QS7 (Cytochalasin B)
SB  - IM
MH  - Animals
MH  - Cattle
MH  - Cytochalasin B/pharmacology
MH  - Embryo, Mammalian/*cytology/drug effects/*physiology
MH  - Female
MH  - Humans
MH  - Meiosis/drug effects
MH  - Oocytes/cytology/drug effects/*metabolism
MH  - *Parthenogenesis
MH  - Ploidies
EDAT- 2011/06/15 06:00
MHDA- 2011/07/27 06:00
CRDT- 2011/06/15 06:00
PHST- 2011/06/15 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
PST - ppublish
SO  - Biocell. 2011 Apr;35(1):1-7.


PMID- 21667649
OWN - NLM
STAT- MEDLINE
DCOM- 20110630
LR  - 20161125
IS  - 0954-7762 (Print)
IS  - 0954-7762 (Linking)
VI  - 107
IP  - 9
DP  - 2011 Mar 8-14
TI  - Ethical issues in patient restraint.
PG  - 18-20
AB  - This article examines the ethical issues that arise in relation to restraint in
      mental health, dementia care and stroke care. The themes can, however, be applied
      to all areas of healthcare. The article also discusses how "four quadrants" of
      practice situations--medical indications, patient preferences, quality of life
      and contextual features--can be used to analyse three different restraint
      situations.
FAU - Gallagher, Ann
AU  - Gallagher A
AD  - International Centre for Nursing Ethics, University of Surrey.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Times
JT  - Nursing times
JID - 0423236
MH  - *Ethics, Nursing
MH  - Humans
MH  - Patient Rights/*ethics
MH  - Restraint, Physical/*ethics
MH  - United Kingdom
EDAT- 2011/06/15 06:00
MHDA- 2011/07/01 06:00
CRDT- 2011/06/15 06:00
PHST- 2011/06/15 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2011/07/01 06:00 [medline]
PST - ppublish
SO  - Nurs Times. 2011 Mar 8-14;107(9):18-20.


PMID- 21666980
OWN - NLM
STAT- MEDLINE
DCOM- 20111006
LR  - 20141120
IS  - 1699-5198 (Electronic)
IS  - 0212-1611 (Linking)
VI  - 26
IP  - 2
DP  - 2011 Mar-Apr
TI  - [Percutaneous endoscopic gastrostomy: a 7 years experience long-term tube
      feeding. Follow-up].
PG  - 399-401
LID - 10.1590/S0212-16112011000200023 [doi]
LID - S0212-16112011000200023 [pii]
AB  - Percutaneous endoscopic gastrostomy (PEG) is the first choice method for
      long-term enteral feeding when the digestive tube is undamaged and the patients' 
      survival is longer than 2 months. There are increasing series and indications
      reported and although it is a safe technique we should take into account an
      appropriate patient selection. The aim of this work was to analyze the follow-up 
      of the patients undergoing percutaneous endoscopic gastrostomy (PEG) at a
      hospital with high assistance level and one of the referents for organ
      transplantation in our community, with the peculiarities that this may have on
      our series. We analyze a cohort of 73 patients submitted to PEG during the years 
      2000-2007 at the Reina Sofia Hospital of Cordoba. Neurological and ENT neoplasms 
      and upper GI tract neoplasms are among the most frequent causes, with similar
      results to those reported in other series. We highlight the number of young
      patients with cystic fibrosis (CF) in our series with nutritional support through
      PEG complementing oral and nocturnal feeding, which has lead to improved
      nutritional parameters before lung transplant. In consequence, we therefore
      analyze patients' selection and their characteristics, the ethical and moral
      implications in some of these patients, such in neurological patients, their
      complications, mortality, and we mention as being of interest the transient and
      well tolerated indication in a subgroup of CF patients that deserves special
      mention.
FAU - Rodriguez Ortega, P
AU  - Rodriguez Ortega P
AD  - Servicio de Endocrinologia y Nutricion, Hospital Infanta Cristina, Badajoz,
      Espana. prodriguezort@hotmail.com
FAU - Calanas Continente, A
AU  - Calanas Continente A
FAU - Molina Puertas, M J
AU  - Molina Puertas MJ
FAU - Gutierrez Alcantara, C
AU  - Gutierrez Alcantara C
FAU - Benito Lopez, P
AU  - Benito Lopez P
FAU - Lavado Hernandez, R
AU  - Lavado Hernandez R
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Gastrostomia Endoscopica Percutanea: 7 anos de experiencia en nutricion enteral a
      largo plazo. Seguimiento clinico.
PL  - Spain
TA  - Nutr Hosp
JT  - Nutricion hospitalaria
JID - 9100365
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cohort Studies
MH  - Cystic Fibrosis/complications/therapy
MH  - *Endoscopy, Gastrointestinal/adverse effects
MH  - *Enteral Nutrition/adverse effects
MH  - Follow-Up Studies
MH  - Gastrointestinal Neoplasms/complications/surgery
MH  - *Gastrostomy/adverse effects
MH  - Humans
MH  - Lung Transplantation
MH  - Middle Aged
MH  - Minimally Invasive Surgical Procedures
MH  - Nervous System Diseases/complications/therapy
MH  - Organ Transplantation
EDAT- 2011/06/15 06:00
MHDA- 2011/10/07 06:00
CRDT- 2011/06/14 06:00
PHST- 2010/01/13 00:00 [received]
PHST- 2010/06/09 00:00 [accepted]
PHST- 2011/06/14 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2011/10/07 06:00 [medline]
AID - S0212-16112011000200023 [pii]
AID - 10.1590/S0212-16112011000200023 [doi]
PST - ppublish
SO  - Nutr Hosp. 2011 Mar-Apr;26(2):399-401. doi: 10.1590/S0212-16112011000200023.


PMID- 21665855
OWN - NLM
STAT- MEDLINE
DCOM- 20120717
LR  - 20120312
IS  - 1938-2715 (Electronic)
IS  - 1049-9091 (Linking)
VI  - 29
IP  - 2
DP  - 2012 Mar
TI  - Ethics and palliative care: which consultant and when?
PG  - 146-50
LID - 10.1177/1049909111410560 [doi]
AB  - Over the past 30 years, and increasingly over the past decade, palliative care
      services characteristically address the complexity of communication, decision
      making, and management of end-of-life issues for patients and families of all
      ages. Clinical ethics services have a parallel 30-plus year history in the United
      States-so much so that some have offered that clinical ethics has "cut its teeth"
      on issues attendant to the beginning and end of life. The authors propose
      considerations necessary in determining the appropriateness of consultation with 
      palliative care, clinical ethics, or both, and when either may be necessary but
      perhaps not sufficient for patient and family management. A resolution for any
      encountered tension and identification of common or overlapping domains for both 
      consultants is presented.
FAU - Carter, Brian S
AU  - Carter BS
AD  - Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
      Brian.Carter@Vanderbilt.edu
FAU - Wocial, Lucia D
AU  - Wocial LD
LA  - eng
PT  - Journal Article
DEP - 20110610
PL  - United States
TA  - Am J Hosp Palliat Care
JT  - The American journal of hospice & palliative care
JID - 9008229
SB  - IM
MH  - Decision Making
MH  - Ethics Consultation/*standards
MH  - *Ethics, Clinical
MH  - Humans
MH  - Palliative Care/*ethics
MH  - Terminal Care/*ethics
MH  - United States
EDAT- 2011/06/15 06:00
MHDA- 2012/07/18 06:00
CRDT- 2011/06/14 06:00
PHST- 2011/06/14 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2012/07/18 06:00 [medline]
AID - 1049909111410560 [pii]
AID - 10.1177/1049909111410560 [doi]
PST - ppublish
SO  - Am J Hosp Palliat Care. 2012 Mar;29(2):146-50. doi: 10.1177/1049909111410560.
      Epub 2011 Jun 10.


PMID- 21665854
OWN - NLM
STAT- MEDLINE
DCOM- 20120601
LR  - 20161125
IS  - 1938-2715 (Electronic)
IS  - 1049-9091 (Linking)
VI  - 29
IP  - 1
DP  - 2012 Feb
TI  - End-of-life issues in caring for patients with dementia: the case for palliative 
      care in management of terminal dementia.
PG  - 9-12
LID - 10.1177/1049909111410306 [doi]
AB  - The number of people suffering with dementia is increasing in the general
      population and the trend is projected to continue as people live longer,
      especially in countries with developed economies. The most common cause of
      dementia (among the many other causes) is Alzheimer's dementia, which is
      considered a terminal illness. The disease could eventually lead to death, or
      death could occur as a consequence of co-morbid physical complications. The
      problem of end of life (EOL) care for patients suffering from dementia though
      spoken of and written about, does not get the attention and system support as for
      example patients suffering from cancer receive. Many reasons have been advanced
      for the current state of affairs where EOL issues for patients suffering from
      dementia are concerned. This article attempts to revisit the issues, and the
      reasons, that may contribute to this. Some guidelines on palliative management in
      cases of patients suffering from severe dementia exist; the evidence base for
      these guidelines though is relatively weak. The ethical and legal issues that may
      influence or impact on the decision to initiate the palliative care pathway in
      the management of EOL issues for dementia patients in the terminal or end stage
      of the illness is highlighted. Initiatives by the department of health in England
      and Wales, and other bodies with interest in dementia issues and palliative care 
      in the United Kingdom to ensure good and acceptable EOL pathways for patients
      with dementia are mentioned.
FAU - Coleman, Albert M E
AU  - Coleman AM
AD  - Avon and Wiltshire NHS Trust, The Coppice, Brislington, Bristol, UK.
      albert.coleman@gmail.com
LA  - eng
PT  - Journal Article
DEP - 20110610
PL  - United States
TA  - Am J Hosp Palliat Care
JT  - The American journal of hospice & palliative care
JID - 9008229
SB  - IM
MH  - Advance Directive Adherence/*ethics/standards
MH  - Comorbidity
MH  - Critical Pathways
MH  - Dementia/complications/psychology/*therapy
MH  - Healthcare Disparities/ethics
MH  - Humans
MH  - Palliative Care/*ethics/standards
MH  - Practice Guidelines as Topic
MH  - Terminal Care/*ethics/standards
MH  - United Kingdom
EDAT- 2011/06/15 06:00
MHDA- 2012/06/02 06:00
CRDT- 2011/06/14 06:00
PHST- 2011/06/14 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2012/06/02 06:00 [medline]
AID - 1049909111410306 [pii]
AID - 10.1177/1049909111410306 [doi]
PST - ppublish
SO  - Am J Hosp Palliat Care. 2012 Feb;29(1):9-12. doi: 10.1177/1049909111410306. Epub 
      2011 Jun 10.


PMID- 21665554
OWN - NLM
STAT- MEDLINE
DCOM- 20111123
LR  - 20110725
IS  - 1552-5279 (Electronic)
IS  - 1552-5260 (Linking)
VI  - 7
IP  - 4
DP  - 2011 Jul
TI  - Presymptomatic apolipoprotein E genotyping for Alzheimer's disease risk
      assessment and prevention.
PG  - e118-23
LID - 10.1016/j.jalz.2010.06.003 [doi]
AB  - Current practice guidelines advocate apolipoprotein E (APOE) genotyping in cases 
      of dementia and mild cognitive impairment and also in asymptomatic participants
      within the context of clinical/epidemiological research. APOE genotyping is not
      recommended for prognostication in cognitively intact persons outside the
      research arena. On the basis of emerging developments, in this article, we
      revisit the notion that presymptomatic APOE testing might be medically
      appropriate and ethical for the purpose of Alzheimer's disease (AD) risk
      assessment and prevention. In support of this thesis, recent evidence is adduced 
      indicating that (i) the potency of potentially modifiable AD determinants and
      responsiveness to intervention may be affected by the presence or absence of the 
      epsilon4 allele, (ii) disclosure of APOE status to asymptomatic individuals
      seeking AD risk assessment is well tolerated when appropriate safeguards are in
      place, and (iii) awareness of personal AD risk in general, and APOE status in
      particular, may motivate individuals to engage in beneficial, risk-lowering
      behaviors.
CI  - Copyright (c) 2011 The Alzheimer's Association. Published by Elsevier Inc. All
      rights reserved.
FAU - Schipper, Hyman M
AU  - Schipper HM
AD  - Centre for Neurotranslational Research and Bloomfield Centre for Research in
      Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill
      University, Montreal, Quebec, Canada. hyman.schipper@mcgill.ca
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110614
PL  - United States
TA  - Alzheimers Dement
JT  - Alzheimer's & dementia : the journal of the Alzheimer's Association
JID - 101231978
RN  - 0 (Apolipoproteins E)
SB  - IM
MH  - Alzheimer Disease/*genetics/*prevention & control/psychology
MH  - Apolipoproteins E/*genetics
MH  - Genotype
MH  - Humans
MH  - Neuropsychological Tests
MH  - *Risk Assessment
EDAT- 2011/06/15 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/06/14 06:00
PHST- 2009/06/08 00:00 [received]
PHST- 2010/05/25 00:00 [revised]
PHST- 2010/06/03 00:00 [accepted]
PHST- 2011/06/14 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S1552-5260(10)02182-5 [pii]
AID - 10.1016/j.jalz.2010.06.003 [doi]
PST - ppublish
SO  - Alzheimers Dement. 2011 Jul;7(4):e118-23. doi: 10.1016/j.jalz.2010.06.003. Epub
      2011 Jun 14.


PMID- 21665203
OWN - NLM
STAT- MEDLINE
DCOM- 20120321
LR  - 20161125
IS  - 1973-8102 (Electronic)
IS  - 0010-9452 (Linking)
VI  - 47
IP  - 10
DP  - 2011 Nov-Dec
TI  - Brain imaging in psychosis and psychopathy--ethical considerations.
PG  - 1236-9
LID - 10.1016/j.cortex.2011.05.005 [doi]
FAU - Robinson, Louise
AU  - Robinson L
AD  - Division of Psychiatry, The University of Edinburgh, Royal Edinburgh Hospital,
      UK. Louise.Robinson@ed.ac.uk
FAU - Sprooten, Emma
AU  - Sprooten E
FAU - Lawrie, Stephen M
AU  - Lawrie SM
LA  - eng
PT  - Journal Article
DEP - 20110517
PL  - Italy
TA  - Cortex
JT  - Cortex; a journal devoted to the study of the nervous system and behavior
JID - 0100725
SB  - IM
MH  - *Bioethical Issues/legislation & jurisprudence
MH  - Brain/*diagnostic imaging/pathology
MH  - Functional Neuroimaging/*ethics
MH  - Humans
MH  - Mental Disorders/diagnostic imaging/pathology
MH  - Psychotic Disorders/*diagnostic imaging/pathology
MH  - Radiography
MH  - Schizophrenia/*diagnostic imaging/pathology
EDAT- 2011/06/15 06:00
MHDA- 2012/03/22 06:00
CRDT- 2011/06/14 06:00
PHST- 2010/11/30 00:00 [received]
PHST- 2011/04/28 00:00 [revised]
PHST- 2011/05/06 00:00 [accepted]
PHST- 2011/06/14 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2012/03/22 06:00 [medline]
AID - S0010-9452(11)00149-3 [pii]
AID - 10.1016/j.cortex.2011.05.005 [doi]
PST - ppublish
SO  - Cortex. 2011 Nov-Dec;47(10):1236-9. doi: 10.1016/j.cortex.2011.05.005. Epub 2011 
      May 17.


PMID- 21664988
OWN - NLM
STAT- MEDLINE
DCOM- 20120201
LR  - 20110909
IS  - 1559-2030 (Electronic)
IS  - 1551-7144 (Linking)
VI  - 32 Suppl 1
DP  - 2011 Sep
TI  - Continuous safety monitoring for randomized controlled clinical trials with
      blinded treatment information. Part 3: Design considerations.
PG  - S8-10
LID - 10.1016/j.cct.2011.05.011 [doi]
AB  - Ongoing safety monitoring of clinical trials of investigational treatments must
      operate at levels that range from the minute and detailed - namely, mathematical 
      treatment of trial data - to the philosophical and societal - namely, ethical
      concerns for individuals and populations. Between those two poles lies a realm of
      environmental and pragmatic considerations that reflect the goals, biases,
      risk-tolerance, and constraints of study sponsors and organizers. These factors, 
      while more difficult to quantify or, at times, to justify, also have a meaningful
      impact on the approach to safety monitoring and the resulting actions and
      outcomes. This paper considers the influence and interaction of two such factors,
      study design and statistical framework, on continuous safety monitoring
      procedures. Group sequential designs have been generally preferred for clinical
      trials over continuous sequential designs because of practical considerations.
      The group means and greater time for deliberation when using a group sequential
      procedure, as opposed to a continuous sequential procedure, can improve the
      quality of the analyses with minimal loss in sensitivity. However, undertaking
      any sequential analysis within a frequentist framework provokes considerable
      theoretical and practical difficulties. Continuous monitoring with a likelihood
      based method, on the other hand, has the advantages that all available
      information, including new data, can be used; sample sizes need not be fixed; and
      decisions can be made at any time without statistical penalty, irrespective of
      trial design. Such responsive statistical rules are needed to provide guidance to
      the human beings charged with trial monitoring.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Ball, Greg
AU  - Ball G
AD  - Astellas Pharma Global Development, 3 Parkway N, Deerfield, IL 60015, USA.
      greg.ball@us.astellas.com
FAU - Silverman, Michael H
AU  - Silverman MH
LA  - eng
PT  - Journal Article
DEP - 20110606
PL  - United States
TA  - Contemp Clin Trials
JT  - Contemporary clinical trials
JID - 101242342
SB  - IM
MH  - Double-Blind Method
MH  - Early Termination of Clinical Trials/economics
MH  - Humans
MH  - Operations Research
MH  - Patient Safety/standards
MH  - *Patient Selection
MH  - *Randomized Controlled Trials as Topic/methods/standards
MH  - Research Design/*standards
MH  - Sample Size
MH  - Single-Blind Method
EDAT- 2011/06/15 06:00
MHDA- 2012/02/02 06:00
CRDT- 2011/06/14 06:00
PHST- 2010/12/09 00:00 [received]
PHST- 2011/04/12 00:00 [revised]
PHST- 2011/05/21 00:00 [accepted]
PHST- 2011/06/14 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2012/02/02 06:00 [medline]
AID - S1551-7144(11)00137-6 [pii]
AID - 10.1016/j.cct.2011.05.011 [doi]
PST - ppublish
SO  - Contemp Clin Trials. 2011 Sep;32 Suppl 1:S8-10. doi: 10.1016/j.cct.2011.05.011.
      Epub 2011 Jun 6.


PMID- 21664987
OWN - NLM
STAT- MEDLINE
DCOM- 20120201
LR  - 20110909
IS  - 1559-2030 (Electronic)
IS  - 1551-7144 (Linking)
VI  - 32 Suppl 1
DP  - 2011 Sep
TI  - Continuous safety monitoring for randomized controlled clinical trials with
      blinded treatment information. Part 1: Ethical considerations.
PG  - S2-4
LID - 10.1016/j.cct.2011.05.010 [doi]
AB  - The protection of patient safety is the principal responsibility of clinical
      trial investigators, and must be assured even if that were to prevent successful 
      completion of a trial. Yet, the decision to prematurely stop a blinded,
      randomized controlled clinical trial can be extremely complicated, involving a
      tangle of ethical, statistical, and practical issues. Questions are quickly
      answered when conclusive evidence of harm has been established for trial
      participants, or when the potential for harm exceeds an acceptable limit of
      comfort for an oversight body. Less readily addressed are those situations in
      which early alarms warn of possible harm, but the data are too preliminary or
      incomplete to reach a satisfactory decision as to whether or not to stop the
      study. Early study termination without sufficient evidence disallows the study
      question from being answered and may allow an inferior treatment to remain in
      use, or prevent a superior one from being discovered. Even without early
      stopping, as a study proceeds, worrisome trends may lead to overzealous (or
      overly cautious) looks at study data which could jeopardize the integrity of the 
      findings. Trial investigators and safety monitoring groups, aided by objective
      statistical rules and thoughtful deliberations, share responsibility for patient 
      welfare. Statistical guidelines must not frustrate ethical concerns, but, rather,
      should be designed to promote the highest ethical and scientific outcomes
      possible, safeguarding both trial participants and the public - the ultimate
      beneficiaries of clinical trials.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Ball, Greg
AU  - Ball G
AD  - Astellas Pharma Global Development, 3 Parkway N, Deerfield, IL 60015, USA.
      greg.ball@us.astellas.com
FAU - Piller, Linda B
AU  - Piller LB
FAU - Silverman, Michael H
AU  - Silverman MH
LA  - eng
PT  - Journal Article
DEP - 20110606
PL  - United States
TA  - Contemp Clin Trials
JT  - Contemporary clinical trials
JID - 101242342
SB  - IM
MH  - Clinical Trials Data Monitoring Committees/standards
MH  - Decision Making
MH  - Double-Blind Method
MH  - Early Termination of Clinical Trials/*ethics
MH  - Ethics, Research
MH  - Humans
MH  - *Monitoring, Physiologic/psychology/standards
MH  - Patient Safety/standards
MH  - Randomized Controlled Trials as Topic/*ethics/methods/standards
MH  - Researcher-Subject Relations/*psychology
MH  - Risk Assessment
MH  - Social Responsibility
EDAT- 2011/06/15 06:00
MHDA- 2012/02/02 06:00
CRDT- 2011/06/14 06:00
PHST- 2010/12/09 00:00 [received]
PHST- 2011/04/12 00:00 [revised]
PHST- 2011/05/21 00:00 [accepted]
PHST- 2011/06/14 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2012/02/02 06:00 [medline]
AID - S1551-7144(11)00136-4 [pii]
AID - 10.1016/j.cct.2011.05.010 [doi]
PST - ppublish
SO  - Contemp Clin Trials. 2011 Sep;32 Suppl 1:S2-4. doi: 10.1016/j.cct.2011.05.010.
      Epub 2011 Jun 6.


PMID- 21664297
OWN - NLM
STAT- MEDLINE
DCOM- 20111206
LR  - 20151119
IS  - 1559-2030 (Electronic)
IS  - 1551-7144 (Linking)
VI  - 32
IP  - 5
DP  - 2011 Sep
TI  - Analysis of the compliance of informed consent documents with good clinical
      practice guideline.
PG  - 662-6
LID - 10.1016/j.cct.2011.05.016 [doi]
AB  - BACKGROUND: Informed consent document plays an integral part in the process of
      obtaining informed consent. Although India is fast gaining repute as a preferred 
      clinical trial destination, only few studies have evaluated the compliance of
      informed consent documents with the Indian Good Clinical Practice guideline.
      METHODS: Retrospective analysis of consent documents submitted to the
      institutional ethics committee during the periods January 2007-July 2008 and
      August 2008-December 2009, for the inclusion of 14 essential information elements
      outlined in the Indian Good Clinical Practice guideline was carried out.
      Cumulative scores were given for compliance with the guideline and for vernacular
      translations of the consent documents. RESULTS: Majority of the informed consent 
      documents analyzed were for academic projects in both periods. There was marked
      improvement in the documents in terms of compliance with Indian GCP in the period
      2008-09. The mean cumulative score for consent documents for academic projects
      increased significantly from 7.00 +/- 0.25 in 2007-08 to 8.57 +/- 0.16 in
      2008-09. The mean score for consent documents for pharmaceutical sponsored
      studies also increased from 10.23 +/- 0.17 in 2007-08 to 11.31 +/- 0.32 in
      2008-09. Additionally, greater number of consent documents had been translated
      into vernacular language in the period 2008-29. CONCLUSIONS: The increased
      compliance with the good clinical practice guideline and improvement in the mean 
      cumulative scores in 2008-09 was probably the outcome of greater awareness
      amongst the clinical researchers within the institute.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Padhy, Biswa M
AU  - Padhy BM
AD  - Department of Pharmacology, All India Institute of Medical Sciences, New Delhi
      29, India. drbisu7@gmail.com
FAU - Gupta, Pooja
AU  - Gupta P
FAU - Gupta, Yogendra K
AU  - Gupta YK
LA  - eng
PT  - Journal Article
DEP - 20110602
PL  - United States
TA  - Contemp Clin Trials
JT  - Contemporary clinical trials
JID - 101242342
SB  - IM
MH  - Chi-Square Distribution
MH  - Clinical Trials as Topic/*ethics/standards
MH  - *Ethics, Research
MH  - Humans
MH  - India
MH  - Informed Consent/ethics/*standards
MH  - Patient Selection
MH  - Practice Guidelines as Topic/*standards
MH  - Practice Patterns, Physicians'/ethics/*standards
MH  - Retrospective Studies
MH  - Statistics, Nonparametric
EDAT- 2011/06/15 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/06/14 06:00
PHST- 2010/12/24 00:00 [received]
PHST- 2011/05/22 00:00 [revised]
PHST- 2011/05/28 00:00 [accepted]
PHST- 2011/06/14 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S1551-7144(11)00142-X [pii]
AID - 10.1016/j.cct.2011.05.016 [doi]
PST - ppublish
SO  - Contemp Clin Trials. 2011 Sep;32(5):662-6. doi: 10.1016/j.cct.2011.05.016. Epub
      2011 Jun 2.


PMID- 21664163
OWN - NLM
STAT- MEDLINE
DCOM- 20120110
LR  - 20211020
IS  - 1953-8022 (Electronic)
IS  - 1246-7820 (Linking)
VI  - 18
IP  - 4
DP  - 2011 Aug
TI  - [Acknowledged risks in transfusion and impact of taken measures on those risks].
PG  - 463-7
LID - 10.1016/j.tracli.2011.05.001 [doi]
AB  - Transfusion is indeed associated with risks that are diverse in nature. Besides, 
      the society expects a risk- and vice-exempt transfusion. During the recent past
      years, there have been three levels of safety implementation in transfusion: a
      generalized risk assessment policy; a mastering of processes; standard quality
      engineering. However, these safety measures have impacts in several ways, such as
      management and organization, inventory, economics and possibly ethics. All these 
      issues are addressed in the present essay as well as the possible effect of
      pathogen reduction procedures.
CI  - Copyright (c) 2011 Elsevier Masson SAS. All rights reserved.
FAU - Garraud, Olivier
AU  - Garraud O
AD  - EFS Auvergne-Loire Saint-Etienne, Saint-Etienne, France.
      olivier.garraud@efs.sante.fr
LA  - fre
PT  - Journal Article
TT  - Risques connus et impact de mesures prises sur ces risques en transfusion
      sanguine.
DEP - 20110612
PL  - France
TA  - Transfus Clin Biol
JT  - Transfusion clinique et biologique : journal de la Societe francaise de
      transfusion sanguine
JID - 9423846
SB  - IM
MH  - Humans
MH  - Risk Assessment
MH  - Risk Management
MH  - *Transfusion Reaction
PMC - PMC7110897
EDAT- 2011/06/15 06:00
MHDA- 2012/01/11 06:00
CRDT- 2011/06/14 06:00
PHST- 2011/06/14 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2012/01/11 06:00 [medline]
AID - S1246-7820(11)00105-4 [pii]
AID - 10.1016/j.tracli.2011.05.001 [doi]
PST - ppublish
SO  - Transfus Clin Biol. 2011 Aug;18(4):463-7. doi: 10.1016/j.tracli.2011.05.001. Epub
      2011 Jun 12.


PMID- 21664018
OWN - NLM
STAT- MEDLINE
DCOM- 20111121
LR  - 20151119
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 73
IP  - 1
DP  - 2011 Jul
TI  - Eliciting ethical and social values in health technology assessment: A
      participatory approach.
PG  - 135-44
LID - 10.1016/j.socscimed.2011.04.017 [doi]
AB  - Despite a growing consensus that ethical and social values should be addressed in
      health technology assessment (HTA) processes, there exist a variety of methods
      for doing so. There is growing interest in involving citizens in policy
      development to ensure that decisions are legitimate, and reflect the broad social
      values of the public. We sought to bring these issues together by employing a
      participatory approach to elicit ethical and social values in HTA. Our primary
      objective was to elicit a set of ethical and social values from citizens that
      could be used to guide Ontario's HTA evidentiary review and appraisal process. A 
      secondary objective was to explore the feasibility of using participatory
      approaches to elicit these values. A 14-person Citizens' Reference Panel on
      Health Technologies was established to provide input to the Ontario Health
      Technology Advisory Committee in developing its recommendations. A mixed methods 
      approach was used where informed, deliberative discussions were combined with
      pre- and post-questionnaires, which assessed the relative importance of various
      ethical and social values as well as their stability over time. Over the course
      of five meetings, panel members progressed toward the identification of a set of 
      core values -universal access, choice and quality care. These values were
      consistently prioritized as the core values that should be considered in the
      evaluation of health technologies and ensuing recommendations. Sustained and
      deliberative methods, like a citizens' panel, offer a promising approach for
      eliciting ethical and social values into HTA.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Bombard, Yvonne
AU  - Bombard Y
AD  - Department of Health Policy Management and Evaluation, University of Toronto, 155
      College Street, 4th Floor, Toronto, Ontario, Canada M5T 3M6.
      yvonne.bombard@utoronto.ca
FAU - Abelson, Julia
AU  - Abelson J
FAU - Simeonov, Dorina
AU  - Simeonov D
FAU - Gauvin, Francois-Pierre
AU  - Gauvin FP
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110523
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Community-Based Participatory Research
MH  - Female
MH  - Health Policy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Ontario
MH  - *Social Values
MH  - Surveys and Questionnaires
MH  - Technology Assessment, Biomedical/*ethics
MH  - Young Adult
EDAT- 2011/06/15 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/06/14 06:00
PHST- 2010/10/11 00:00 [received]
PHST- 2011/04/08 00:00 [revised]
PHST- 2011/04/13 00:00 [accepted]
PHST- 2011/06/14 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0277-9536(11)00254-1 [pii]
AID - 10.1016/j.socscimed.2011.04.017 [doi]
PST - ppublish
SO  - Soc Sci Med. 2011 Jul;73(1):135-44. doi: 10.1016/j.socscimed.2011.04.017. Epub
      2011 May 23.


PMID- 21663867
OWN - NLM
STAT- MEDLINE
DCOM- 20111101
LR  - 20151119
IS  - 1878-7487 (Electronic)
IS  - 1752-928X (Linking)
VI  - 18
IP  - 5
DP  - 2011 Jul
TI  - Medical ethics educational improvement, is it needed or not?! Survey for the
      assessment of the needed form, methods and topics of medical ethics teaching
      course amongst the final years medical students Faculty of Medicine Ain Shams
      University (ASU), Cairo, Egypt 2010.
PG  - 204-7
LID - 10.1016/j.jflm.2011.02.012 [doi]
AB  - INTRODUCTION: In the process of our faculty gaining accreditation, the debate
      concerning the necessity for initiating an integrated course in which medical
      ethics course is implemented have arouse. Arguments concerning what should this
      course include, the best timing for this course to be applied, how it should be
      taught, planned for and mostly for what the students are interested to get out of
      it. GOAL: The main purpose of this work is to identify the ethical needs and
      ethical dilemmas freshly graduated medical students face at the beginning of
      their training and their suggestions to seek better educational approaches that
      can be applied in teaching medical ethics proposed by the medical students
      themselves throughout the teaching process and after graduation. METHODS: It
      seemed rather appropriate at this stage to carry out an evaluation survey
      assessing the needs for medical ethics teaching course through the exploration of
      the opinions of medical students and freshly graduated doctors on ethical issues 
      through a simple survey by using an open ended question questionnaire designed to
      fulfil the study targeted requirements. RESULTS: 100 volunteers (n = 100)
      randomly chosen from the fifth year students of our faculty of medicine ASU who
      had recently studied ethics course in the fourth year (n = 20), interns both
      junior and senior residents in El Demerdash hospitals (n = 80). 25 questionnaires
      were excluded due to inappropriate or missing answers resulting in 75% response
      rate. 60% of the surveyed group favored an integrated ethics course taught
      throughout the whole academic years study. 56% chose the practical teaching
      method with problem solving strategies for the daily arising confusing ethical
      issues to be the best way to teach the course. While 53.4% thought that stuff
      specialized in medico legal issues were best to teach this course. As regards the
      highly confusing ethical dilemmas in which they were interested in getting
      updated feedback about: Confidentiality, doctor-patient relationship and informed
      consent came first by 69.3%. CONCLUSIONS: This study revealed the essential need 
      for a model medical ethics curriculum that responds to students' concerns in
      addition to providing basic training in moral reasoning and ethical decision
      making to be applied both horizontally and vertically across the whole years of
      medical school. RECOMMENDATIONS: A Simple booklet containing recent version of
      the Egyptian code of ethics, common ethical dilemmas and recently evolving
      ethical issues should be available for all newly graduated health professionals.
CI  - Copyright (c) 2011 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All
      rights reserved.
FAU - Fawzi, Marwa M
AU  - Fawzi MM
AD  - Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Ain
      Shams University, Cairo, Egypt. marwamohfawzi@gmail.com
LA  - eng
PT  - Journal Article
DEP - 20110321
PL  - England
TA  - J Forensic Leg Med
JT  - Journal of forensic and legal medicine
JID - 101300022
SB  - IM
MH  - Bioethical Issues
MH  - Curriculum
MH  - *Education, Medical, Graduate
MH  - Egypt
MH  - Ethics, Medical/*education
MH  - Humans
MH  - *Needs Assessment
MH  - Schools, Medical
MH  - *Students, Medical
MH  - Surveys and Questionnaires
MH  - Teaching
EDAT- 2011/06/15 06:00
MHDA- 2011/11/02 06:00
CRDT- 2011/06/14 06:00
PHST- 2011/01/22 00:00 [received]
PHST- 2011/02/20 00:00 [accepted]
PHST- 2011/06/14 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2011/11/02 06:00 [medline]
AID - S1752-928X(11)00051-5 [pii]
AID - 10.1016/j.jflm.2011.02.012 [doi]
PST - ppublish
SO  - J Forensic Leg Med. 2011 Jul;18(5):204-7. doi: 10.1016/j.jflm.2011.02.012. Epub
      2011 Mar 21.


PMID- 21663779
OWN - NLM
STAT- MEDLINE
DCOM- 20111216
LR  - 20161125
IS  - 1095-8304 (Electronic)
IS  - 0195-6663 (Linking)
VI  - 57
IP  - 2
DP  - 2011 Oct
TI  - Measuring salient food attitudes and food-related values. An elaborated,
      conflicting and interdependent system.
PG  - 329-38
LID - 10.1016/j.appet.2011.05.322 [doi]
AB  - Consumer food choice behaviour in post-industrial countries is complex and
      influenced by a multitude of interacting variables. This study looked at the
      antecedents of behaviour and examined salient food-related values and attitudes. 
      To discover personal meanings and patterns of everyday food choices across
      different situations we used a qualitative approach in the form of repertory grid
      interviews. An analysis of the personal constructs elicited from a representative
      sample of 100 Swiss consumers revealed elaborated value systems. The food-related
      values can be summarised as: authenticity/naturalness, conviviality, health,
      quality/indulgence, convenience, and price. The salience of these values and
      their negatively evaluated counterparts differed for various social eating
      situations and product categories. Consumers' personal values also differed
      significantly from their perception of current trends in eating culture. In
      every-day food choices interdependent food-related values compete and are thus a 
      possible cause of ambivalence and conflicts. The findings offer explanations of
      discrepancies between values/attitudes and behaviour that may be due to
      situational constraints and habits. Implications for companies include the need
      for strategic realignment to regain consumers' trust by providing comprehensive
      value-congruent food solutions that also consider health and ethical criteria.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Hauser, Mirjam
AU  - Hauser M
AD  - Department of Psychology, University of Zurich, Binzmuhlestrasse 14/13, 8050
      Zurich, Switzerland. mirjam.hauser@uzh.ch
FAU - Jonas, Klaus
AU  - Jonas K
FAU - Riemann, Rainer
AU  - Riemann R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110601
PL  - England
TA  - Appetite
JT  - Appetite
JID - 8006808
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Choice Behavior
MH  - Consumer Behavior
MH  - *Feeding Behavior
MH  - Female
MH  - *Food
MH  - *Food Preferences
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Middle Aged
MH  - Nutritive Value
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2011/06/15 06:00
MHDA- 2011/12/17 06:00
CRDT- 2011/06/14 06:00
PHST- 2011/01/14 00:00 [received]
PHST- 2011/05/06 00:00 [revised]
PHST- 2011/05/24 00:00 [accepted]
PHST- 2011/06/14 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2011/12/17 06:00 [medline]
AID - S0195-6663(11)00479-X [pii]
AID - 10.1016/j.appet.2011.05.322 [doi]
PST - ppublish
SO  - Appetite. 2011 Oct;57(2):329-38. doi: 10.1016/j.appet.2011.05.322. Epub 2011 Jun 
      1.


PMID- 21663713
OWN - NLM
STAT- MEDLINE
DCOM- 20111014
LR  - 20110613
IS  - 1526-3231 (Electronic)
IS  - 0749-8063 (Linking)
VI  - 27
IP  - 5
DP  - 2011 May
TI  - Suggested guidelines for the practice of arthroscopic surgery. Committee on
      Ethics and Standards and the Board of Directors of the Arthroscopy Association of
      North America.
PG  - A28
LID - 10.1016/S0749-8063(11)00344-6 [doi]
CN  - Committee on Ethics and Standards and the Board of Directors of the Arthroscopy
      Association of North America
LA  - eng
PT  - Journal Article
PT  - Practice Guideline
DEP - 20110415
PL  - United States
TA  - Arthroscopy
JT  - Arthroscopy : the journal of arthroscopic & related surgery : official
      publication of the Arthroscopy Association of North America and the International
      Arthroscopy Association
JID - 8506498
SB  - IM
MH  - Arthroscopy/education/methods/*standards
MH  - Education, Medical, Continuing
MH  - Employee Performance Appraisal
MH  - Humans
MH  - Medical Staff Privileges/standards
MH  - Preoperative Care
EDAT- 2011/06/15 06:00
MHDA- 2011/10/15 06:00
CRDT- 2011/06/14 06:00
PHST- 2011/06/14 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2011/10/15 06:00 [medline]
AID - S0749-8063(11)00344-6 [pii]
AID - 10.1016/S0749-8063(11)00344-6 [doi]
PST - ppublish
SO  - Arthroscopy. 2011 May;27(5):A28. doi: 10.1016/S0749-8063(11)00344-6. Epub 2011
      Apr 15.


PMID- 21663698
OWN - NLM
STAT- MEDLINE
DCOM- 20111031
LR  - 20220330
IS  - 1471-2407 (Electronic)
IS  - 1471-2407 (Linking)
VI  - 11
DP  - 2011 Jun 13
TI  - Efficacy of a referral and physical activity program for survivors of prostate
      cancer [ENGAGE]: rationale and design for a cluster randomised controlled trial.
PG  - 237
LID - 10.1186/1471-2407-11-237 [doi]
AB  - BACKGROUND: Despite evidence that physical activity improves the health and
      well-being of prostate cancer survivors, many men do not engage in sufficient
      levels of activity. The primary aim of this study (ENGAGE) is to determine the
      efficacy of a referral and physical activity program among survivors of prostate 
      cancer, in terms of increasing participation in physical activity. Secondary aims
      are to determine the effects of the physical activity program on psychological
      well-being, quality of life and objective physical functioning. The influence of 
      individual and environmental mediators on participation in physical activity will
      also be determined. METHODS/DESIGN: This study is a cluster randomised controlled
      trial. Clinicians of prostate cancer survivors will be randomised into either the
      intervention or control condition. Clinicians in the intervention condition will 
      refer eligible patients (n=110) to participate in an exercise program, comprising
      12 weeks of supervised exercise sessions and unsupervised physical activity.
      Clinicians allocated to the control condition will provide usual care to eligible
      patients (n=110), which does not involve the recommendation of the physical
      activity program. Participants will be assessed at baseline, 12 weeks, 6 months, 
      and 12 months on physical activity, quality of life, anxiety, depression,
      self-efficacy, outcome expectations, goals, and socio-structural factors.
      DISCUSSION: The findings of this study have implications for clinicians and
      patients with different cancer types or other chronic health conditions. It will 
      contribute to our understanding on the potential impact of clinicians promoting
      physical activity to patients and the long term health benefits of participating 
      in physical activity programs. TRIAL REGISTRATION: Australia and New Zealand
      Clinical Trials Register (ANZCTR): ACTRN12610000609055Deakin University Human
      Research Ethics Approval 2011-085.
CI  - (c) 2011 Livingston et al; licensee BioMed Central Ltd.
FAU - Livingston, Patricia M
AU  - Livingston PM
AD  - Faculty of Health, Deakin University, 221 Burwood Highway, Burwood, Victoria
      3125, Australia. trish.livingston@deakin.edu.au
FAU - Salmon, Jo
AU  - Salmon J
FAU - Courneya, Kerry S
AU  - Courneya KS
FAU - Gaskin, Cadeyrn J
AU  - Gaskin CJ
FAU - Craike, Melinda
AU  - Craike M
FAU - Botti, Mari
AU  - Botti M
FAU - Broadbent, Suzanne
AU  - Broadbent S
FAU - Kent, Bridie
AU  - Kent B
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110613
PL  - England
TA  - BMC Cancer
JT  - BMC cancer
JID - 100967800
SB  - IM
MH  - Adenocarcinoma/psychology/*rehabilitation
MH  - Anxiety/epidemiology/etiology/prevention & control
MH  - Australia
MH  - Depression/epidemiology/etiology/prevention & control
MH  - *Exercise Therapy
MH  - Follow-Up Studies
MH  - Goals
MH  - Humans
MH  - Male
MH  - New Zealand
MH  - Patient Selection
MH  - Prostatic Neoplasms/psychology/*rehabilitation
MH  - Quality of Life
MH  - Referral and Consultation
MH  - Self Efficacy
MH  - Severity of Illness Index
MH  - Surveys and Questionnaires
MH  - Survivors/psychology
MH  - Treatment Outcome
PMC - PMC3141765
EDAT- 2011/06/15 06:00
MHDA- 2011/11/01 06:00
CRDT- 2011/06/14 06:00
PHST- 2011/05/06 00:00 [received]
PHST- 2011/06/13 00:00 [accepted]
PHST- 2011/06/14 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2011/11/01 06:00 [medline]
AID - 1471-2407-11-237 [pii]
AID - 10.1186/1471-2407-11-237 [doi]
PST - epublish
SO  - BMC Cancer. 2011 Jun 13;11:237. doi: 10.1186/1471-2407-11-237.


PMID- 21663609
OWN - NLM
STAT- MEDLINE
DCOM- 20111128
LR  - 20211020
IS  - 1471-2288 (Electronic)
IS  - 1471-2288 (Linking)
VI  - 11
DP  - 2011 Jun 10
TI  - Novel study designs to investigate the placebo response.
PG  - 90
LID - 10.1186/1471-2288-11-90 [doi]
AB  - BACKGROUND: Investigating the size and mechanisms of the placebo response in
      clinical trials have relied on experimental procedures that simulate the
      double-blind randomized placebo-controlled design. However, as the conventional
      design is thought to elucidate drug rather than placebo actions, different
      methodological procedures are needed for the placebo response. METHODS: We
      reviewed the respective literature for trials designs that may be used to
      elucidate the size of the placebo response and the mechanisms associated with it.
      RESULTS: In general, this can be done by either manipulation the information
      provided to the subjects, or by manipulation the timing of the drug applied. Two 
      examples of each strategy are discussed: the "balanced placebo design" (BDP) and 
      the "balanced cross-over design" (BCD) and their variants are based on false
      information, while the "hidden treatment" (HT) and the ""delayed response test"
      (DRT) are based on manipulating the time of drug action. Since most such
      approaches include deception or incomplete information of the subjects they are
      suitable for patient only with authorized deception. CONCLUSION: Both
      manipulating the information provided to subjects (BDP, DCD) or manipulating the 
      timing of drug application (HT, DRT) allows overcoming some of the restrictions
      of conventional drug trials in the assessment of the placebo response, but they
      are feasible mostly in healthy subjects for ethical reasons.
FAU - Enck, Paul
AU  - Enck P
AD  - University Hospital Tubingen, Dept, of Psychosomatic Medicine, Tubingen, Germany.
      paul.enck@uni-tuebingen.de
FAU - Klosterhalfen, Sibylle
AU  - Klosterhalfen S
FAU - Zipfel, Stephan
AU  - Zipfel S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110610
PL  - England
TA  - BMC Med Res Methodol
JT  - BMC medical research methodology
JID - 100968545
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - *Clinical Trials as Topic
MH  - Dose-Response Relationship, Drug
MH  - Humans
MH  - Pharmaceutical Preparations
MH  - *Placebo Effect
MH  - *Research Design
PMC - PMC3132201
EDAT- 2011/06/15 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/06/14 06:00
PHST- 2010/09/14 00:00 [received]
PHST- 2011/06/10 00:00 [accepted]
PHST- 2011/06/14 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 1471-2288-11-90 [pii]
AID - 10.1186/1471-2288-11-90 [doi]
PST - epublish
SO  - BMC Med Res Methodol. 2011 Jun 10;11:90. doi: 10.1186/1471-2288-11-90.


PMID- 21661596
OWN - NLM
STAT- MEDLINE
DCOM- 20110630
LR  - 20110613
IS  - 0025-7028 (Print)
IS  - 0025-7028 (Linking)
VI  - 100
IP  - 1
DP  - 2011
TI  - Ethical response to outbreaks of vaccine-preventable diseases.
PG  - 22-3
FAU - Claiborne, Mary Kate
AU  - Claiborne MK
AD  - Mercer University School of Medicine-Savannah, GA, USA.
FAU - Greenberg, Martin
AU  - Greenberg M
FAU - Elliott, Richard L
AU  - Elliott RL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Med Assoc Ga
JT  - Journal of the Medical Association of Georgia
JID - 7505620
SB  - IM
MH  - Bioethics
MH  - Humans
MH  - *Immunity, Herd
MH  - Public Health
MH  - Vaccination/ethics/legislation & jurisprudence/*statistics & numerical data
MH  - Whooping Cough/*prevention & control
EDAT- 2011/06/15 06:00
MHDA- 2011/07/01 06:00
CRDT- 2011/06/14 06:00
PHST- 2011/06/14 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2011/07/01 06:00 [medline]
PST - ppublish
SO  - J Med Assoc Ga. 2011;100(1):22-3.


PMID- 21661476
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20110613
IS  - 1320-3185 (Print)
IS  - 1320-3185 (Linking)
VI  - 18
IP  - 8
DP  - 2011 Mar
TI  - Ethics, cancer, and truth telling.
PG  - 21
FAU - Johnstone, Megan-Jane
AU  - Johnstone MJ
AD  - School of Nursing and Midwifery, Deakin University, Victoria.
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Aust Nurs J
JT  - Australian nursing journal (July 1993)
JID - 9317904
CIN - Aust Nurs J. 2011 Apr;18(9):3. PMID: 21612174
CIN - Aust Nurs J. 2011 Jun;18(11):5. PMID: 21739775
MH  - Australia
MH  - *Codes of Ethics
MH  - Cultural Characteristics
MH  - *Ethics, Nursing
MH  - Humans
MH  - Neoplasms/*psychology
MH  - *Nurse-Patient Relations
MH  - Truth Disclosure/*ethics
EDAT- 2011/06/15 06:00
MHDA- 2011/07/27 06:00
CRDT- 2011/06/14 06:00
PHST- 2011/06/14 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
PST - ppublish
SO  - Aust Nurs J. 2011 Mar;18(8):21.


PMID- 21660998
OWN - NLM
STAT- MEDLINE
DCOM- 20111107
LR  - 20191210
IS  - 1097-0223 (Electronic)
IS  - 0197-3851 (Linking)
VI  - 31
IP  - 7
DP  - 2011 Jul
TI  - Fetal therapy: practical ethical considerations.
PG  - 621-7
LID - 10.1002/pd.2808 [doi]
AB  - Progress in prenatal diagnosis can lead to the diagnosis of severe fetal
      abnormalities for which natural history anticipates a fatal outcome or the
      development of severe disability despite optimal postnatal care. Intrauterine
      therapy can be offered in these selected cases. Prenatal diagnosis is the only
      field of medicine in which termination is an option in the management of severe
      diseases. Fetal therapy has therefore developed as an alternative to fatalist
      expectant prenatal management as well as to termination of pregnancy (TOP). There
      are few standards of fetal care that have gone beyond the stage of equipoise and 
      even fewer have been established based on appropriate studies comparing pre- and 
      postnatal care. Several ethical questions are being raised as fetal surgery
      develops, including basic Hippocratic principles of patients' autonomy and
      doctors' duty of competence moving the boundaries between experimental surgery,
      therapeutic innovation and standard care. In addition, the technical success of a
      fetal intervention can only rarely fully predict the postnatal outcome. Managing 
      uncertainty regarding long-term morbidity and the possibility for fetal therapy
      to change the risk of perinatal death into that of severe handicap remains a
      critical factor affecting women's choice for TOP as an alternative to fetal
      therapy.
CI  - Copyright (c) 2011 John Wiley & Sons, Ltd.
FAU - Ville, Yves
AU  - Ville Y
AD  - Department of Obstetrics and Fetal Medicine, UFR Necker-Enfants-Malades,
      Universite Rene Descartes, 75015 Paris, France. yves.ville@gmail.com
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Review
DEP - 20110610
PL  - England
TA  - Prenat Diagn
JT  - Prenatal diagnosis
JID - 8106540
SB  - IM
MH  - Abortion, Eugenic/statistics & numerical data
MH  - Attitude of Health Personnel
MH  - Congenital Abnormalities/psychology/therapy
MH  - *Ethics, Medical
MH  - Female
MH  - Fetal Therapies/*ethics/*methods/statistics & numerical data/trends
MH  - Humans
MH  - Pregnancy
MH  - Uncertainty
EDAT- 2011/06/11 06:00
MHDA- 2011/11/08 06:00
CRDT- 2011/06/11 06:00
PHST- 2011/04/08 00:00 [received]
PHST- 2011/05/09 00:00 [revised]
PHST- 2011/05/09 00:00 [accepted]
PHST- 2011/06/11 06:00 [entrez]
PHST- 2011/06/11 06:00 [pubmed]
PHST- 2011/11/08 06:00 [medline]
AID - 10.1002/pd.2808 [doi]
PST - ppublish
SO  - Prenat Diagn. 2011 Jul;31(7):621-7. doi: 10.1002/pd.2808. Epub 2011 Jun 10.


PMID- 21660785
OWN - NLM
STAT- MEDLINE
DCOM- 20111103
LR  - 20110610
IS  - 1465-3419 (Electronic)
IS  - 1355-7858 (Linking)
VI  - 16
IP  - 3
DP  - 2011 Jun
TI  - 'We are (not) the master of our body': elderly Jewish women's attitudes towards
      euthanasia and assisted suicide.
PG  - 259-78
LID - 10.1080/13557858.2011.573538 [doi]
AB  - OBJECTIVES: In Belgium, dominant ideological traditions--Christianity and
      non-religious humanism--have the floor in debates on euthanasia and hardly any
      attention is paid to the practices and attitudes of ethnic and religious
      minorities, for instance, Jews. This article aims to meet this lacuna. DESIGN:
      Qualitative empirical research was performed in the Orthodox Jewish community of 
      Antwerp (Belgium) with a purposive sample of elderly Jewish (non-)Hasidic and
      secularised Orthodox women. In-depth interviews were conducted to elicit their
      attitudes towards (non-)voluntary euthanasia and assisted suicide. RESULTS: The
      research reveals diverse views among women in the community on intentionally
      terminating a patient's life. Absolute rejection of every act which deliberately 
      terminates life is found among the overwhelming majority of (religiously
      observant) Orthodox (Hasidic and non-Hasidic) women, as they have an
      unconditional faith and trust in God's sovereign power over the domain of life
      and death. On the other hand, the views of secularised Orthodox women--mostly
      irreligious women, who do not consider themselves Orthodox, thus not following
      Jewish law, yet say they belong to the Orthodox Jewish community--show an
      acceptance of voluntary euthanasia and assisted suicide but non-voluntary
      euthanasia is approached more negatively. As they perceive illness and death as
      merely profane facts, they stress a patient's absolute right towards
      self-determination, in particular with regard to one's end of life. Among
      non-Hasidic Orthodox respondents, more openness is found for cultivating a
      personal opinion which deviates from Jewish law and for the right of
      self-determination with regard to questions concerning life and death. In this
      study, these participants occupy an intermediate position. CONCLUSION: Our study 
      reveals an interplay between ethical attitudes on euthanasia and religious
      convictions. The image one has of a transcendental reality, or of God, has a
      stronger effect on one's (dis)approval of euthanasia than being (ir)religious.
FAU - Baeke, Goedele
AU  - Baeke G
AD  - Faculty of Theology, Interdisciplinary Centre for the Study of Religion and World
      View, Katholieke Universiteit Leuven, Leuven, Belgium.
      Goedele.Baeke@theo.kuleuven.be
FAU - Wils, Jean-Pierre
AU  - Wils JP
FAU - Broeckaert, Bert
AU  - Broeckaert B
LA  - eng
PT  - Journal Article
PL  - England
TA  - Ethn Health
JT  - Ethnicity & health
JID - 9608374
SB  - IM
MH  - Aged
MH  - Belgium
MH  - Ethics, Medical
MH  - Euthanasia/ethics/*psychology
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Jews/psychology/*statistics & numerical data
MH  - Middle Aged
MH  - Qualitative Research
MH  - *Religion
MH  - Sex Factors
MH  - Social Perception
MH  - Suicide, Assisted/ethics/*psychology
EDAT- 2011/06/11 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/06/11 06:00
PHST- 2011/06/11 06:00 [entrez]
PHST- 2011/06/11 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
AID - 938335475 [pii]
AID - 10.1080/13557858.2011.573538 [doi]
PST - ppublish
SO  - Ethn Health. 2011 Jun;16(3):259-78. doi: 10.1080/13557858.2011.573538.


PMID- 21660534
OWN - NLM
STAT- MEDLINE
DCOM- 20111128
LR  - 20211020
IS  - 1432-1238 (Electronic)
IS  - 0342-4642 (Linking)
VI  - 37
IP  - 8
DP  - 2011 Aug
TI  - End-of-life attitudes of intensive care physicians in Poland: results of a
      national survey.
PG  - 1290-6
LID - 10.1007/s00134-011-2269-2 [doi]
AB  - PURPOSE: This study was designed to assess the ethical attitudes and practices of
      intensive care physicians regarding life-sustaining treatment in intensive care
      units (ICUs) in Poland. METHODS: A questionnaire was distributed to intensive
      care physicians taking part in a national medical congress. Participation in the 
      study was voluntary and anonymous. RESULTS: A total of 400 questionnaires were
      distributed, of which 217 (54%) were returned completed. Almost all respondents
      (93%) reported having withheld therapy, and 75% of respondents reported
      withdrawing therapy. Physicians aged 40 years and over who had no religious
      affiliation more frequently reported withholding treatment. Only 5% of physicians
      reported deliberately administering drugs until death ensued. Respondents from
      large hospitals (more than 400 beds) more easily accepted foregoing
      life-sustaining therapy in ICU patients. In clinical scenario in which the family
      demanded the maximum available treatment, physicians reported that they were
      considerably influenced to modify decisions concerning life-sustaining therapy.
      CONCLUSIONS: The ethical attitudes of intensive care physicians regarding
      end-of-life decisions are similar to the opinion presented in other European
      survey studies. The practice of withholding and withdrawing therapy in ICU
      patients is common in Poland. Actively shortening life is considered
      unacceptable. The request of the family even without legal consultation can
      influence physicians' decisions.
FAU - Kubler, Andrzej
AU  - Kubler A
AD  - Department of Anaesthesiology and Intensive Therapy, Wroclaw Medical University, 
      Borowska St. 213, 50-556 Wroclaw, Poland. andrzej.kubler@anest.am.wroc.pl
FAU - Adamik, Barbara
AU  - Adamik B
FAU - Lipinska-Gediga, Malgorzata
AU  - Lipinska-Gediga M
FAU - Kedziora, Jaroslaw
AU  - Kedziora J
FAU - Strozecki, Lukasz
AU  - Strozecki L
LA  - eng
PT  - Journal Article
DEP - 20110610
PL  - United States
TA  - Intensive Care Med
JT  - Intensive care medicine
JID - 7704851
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - *Attitude of Health Personnel
MH  - Catholicism
MH  - Decision Making/ethics
MH  - Euthanasia, Active/*ethics/statistics & numerical data
MH  - Female
MH  - Health Care Surveys
MH  - Humans
MH  - Intensive Care Units/*ethics
MH  - Life Support Care/*ethics/statistics & numerical data
MH  - Male
MH  - Middle Aged
MH  - Physicians/*ethics/psychology
MH  - Poland
MH  - Professional-Family Relations/ethics
MH  - Quality of Life
MH  - Sex Factors
MH  - Withholding Treatment/*ethics/statistics & numerical data
EDAT- 2011/06/11 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/06/11 06:00
PHST- 2010/10/19 00:00 [received]
PHST- 2011/04/05 00:00 [accepted]
PHST- 2011/06/11 06:00 [entrez]
PHST- 2011/06/11 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/s00134-011-2269-2 [doi]
PST - ppublish
SO  - Intensive Care Med. 2011 Aug;37(8):1290-6. doi: 10.1007/s00134-011-2269-2. Epub
      2011 Jun 10.


PMID- 21660506
OWN - NLM
STAT- MEDLINE
DCOM- 20110929
LR  - 20211020
IS  - 1432-1203 (Electronic)
IS  - 0340-6717 (Linking)
VI  - 130
IP  - 3
DP  - 2011 Sep
TI  - Children and biobanks: a review of the ethical and legal discussion.
PG  - 403-13
LID - 10.1007/s00439-011-1031-8 [doi]
AB  - The use of tissue samples from children is vital to genetic research. Collections
      of such tissue, in so-called biobanks, can take the form of large-scale
      prospective cohort studies or disease-specific studies using tissue of children
      with that specific disease. Collections of samples gathered in a diagnostics
      context, such as blood spot cards, can also be used for genetic research.
      Research on stored tissue samples from children poses ethical questions that are 
      different from those posed by the use of samples from adults. Also, the ethical
      questions raised by the participation of children in biobanks are not analogous
      to those raised by the participation of children in clinical trials. In this
      review we first give an overview of the international ethical guidelines and
      legal regulations concerning biobanking and minors. Next, we review the different
      themes that occur in the ethical literature on this subject. Specifically we
      focus on questions of risk and benefit, consent and assent and the return of
      individual results. We also discuss the concept of solidarity, which is a
      relatively new concept in the context of children and biomedical research. To
      conclude, we discuss the gaps and questions raised by the review.
FAU - Hens, Kristien
AU  - Hens K
AD  - Centre for Biomedical Ethics and Law, Katholieke Universiteit Leuven, Box 7001,
      Kapucijnenvoer 35/3, 3000 Leuven, Belgium. Kristien.Hens@med.kuleuven.be
FAU - Levesque, Emmanuelle
AU  - Levesque E
FAU - Dierickx, Kris
AU  - Dierickx K
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110610
PL  - Germany
TA  - Hum Genet
JT  - Human genetics
JID - 7613873
SB  - IM
MH  - Biological Specimen Banks/ethics/organization & administration
MH  - Child
MH  - Child, Preschool
MH  - Guidelines as Topic
MH  - Humans
MH  - Informed Consent
MH  - Legislation, Medical
MH  - Patient Access to Records
MH  - Risk Assessment
MH  - Tissue Banks/*ethics/*legislation & jurisprudence
EDAT- 2011/06/11 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/06/11 06:00
PHST- 2011/05/10 00:00 [received]
PHST- 2011/06/02 00:00 [accepted]
PHST- 2011/06/11 06:00 [entrez]
PHST- 2011/06/11 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - 10.1007/s00439-011-1031-8 [doi]
PST - ppublish
SO  - Hum Genet. 2011 Sep;130(3):403-13. doi: 10.1007/s00439-011-1031-8. Epub 2011 Jun 
      10.


PMID- 21659454
OWN - NLM
STAT- MEDLINE
DCOM- 20120209
LR  - 20110726
IS  - 1469-0756 (Electronic)
IS  - 0032-5473 (Linking)
VI  - 87
IP  - 1030
DP  - 2011 Aug
TI  - A hands-on guide on obtaining research ethics approval.
PG  - 509-13
LID - 10.1136/pgmj.2010.109348 [doi]
AB  - It is an uncontested truth that many medical students and practising clinicians
      dread having to get their research proposal through a research ethics committee. 
      In this paper, the author, a long-standing member of a research ethics committee,
      offers a practical guide on applying for research ethics approval, detailing
      common mistakes and flaws in applications, and giving specific guidance on
      getting through what can seem a daunting process.
FAU - Hunter, David
AU  - Hunter D
AD  - Keele University, Chancellor's Building, Staffordshire, Keele, UK.
      d.hunter@peak.keele.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20110609
PL  - England
TA  - Postgrad Med J
JT  - Postgraduate medical journal
JID - 0234135
SB  - IM
MH  - Confidentiality/ethics
MH  - Disclosure/ethics
MH  - Ethics Committees, Research/*ethics
MH  - *Guidelines as Topic
MH  - Humans
MH  - Informed Consent/ethics
MH  - Research Design/*standards
EDAT- 2011/06/11 06:00
MHDA- 2012/02/10 06:00
CRDT- 2011/06/11 06:00
PHST- 2011/06/11 06:00 [entrez]
PHST- 2011/06/11 06:00 [pubmed]
PHST- 2012/02/10 06:00 [medline]
AID - pgmj.2010.109348 [pii]
AID - 10.1136/pgmj.2010.109348 [doi]
PST - ppublish
SO  - Postgrad Med J. 2011 Aug;87(1030):509-13. doi: 10.1136/pgmj.2010.109348. Epub
      2011 Jun 9.


PMID- 21658262
OWN - NLM
STAT- MEDLINE
DCOM- 20110916
LR  - 20220331
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 12
DP  - 2011 Jun 9
TI  - The challenges and opportunities of conducting a clinical trial in a low resource
      setting: the case of the Cameroon mobile phone SMS (CAMPS) trial, an investigator
      initiated trial.
PG  - 145
LID - 10.1186/1745-6215-12-145 [doi]
AB  - Conducting clinical trials in developing countries often presents significant
      ethical, organisational, cultural and infrastructural challenges to researchers, 
      pharmaceutical companies, sponsors and regulatory bodies. Globally, these regions
      are under-represented in research, yet this population stands to gain more from
      research in these settings as the burdens on health are greater than those in
      developed resourceful countries. However, developing countries also offer an
      attractive setting for clinical trials because they often have larger treatment
      naive populations with higher incidence rates of disease and more advanced
      stages. These factors can present a reduction in costs and time required to
      recruit patients. So, balance needs to be found where research can be encouraged 
      and supported in order to bring maximum public health benefits to these
      communities. The difficulties with such trials arise from problems with obtaining
      valid informed consent, ethical compensation mechanisms for extremely poor
      populations, poor health infrastructure and considerable socio-economic and
      cultural divides. Ethical concerns with trials in developing countries have
      received attention, even though many other non-ethical issues may arise. Local
      investigator initiated trials also face a variety of difficulties that have not
      been adequately reported in literature. This paper uses the example of the
      Cameroon Mobile Phone SMS trial to describe in detail, the specific difficulties 
      encountered in an investigator-initiated trial in a developing country. It
      highlights administrative, ethical, financial and staff related issues, proposes 
      solutions and gives a list of additional documentation to ease the organisational
      process.
FAU - Mbuagbaw, Lawrence
AU  - Mbuagbaw L
AD  - Centre for the Development of Best Practices in Health (CDBPH), Yaounde Central
      Hospital, Yaounde, Cameroon. mbuagbawl@yahoo.com
FAU - Thabane, Lehana
AU  - Thabane L
FAU - Ongolo-Zogo, Pierre
AU  - Ongolo-Zogo P
FAU - Lang, Trudie
AU  - Lang T
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Editorial
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110609
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
RN  - 0 (Anti-Retroviral Agents)
SB  - IM
MH  - Anti-Retroviral Agents/*therapeutic use
MH  - Attitude of Health Personnel
MH  - Cameroon
MH  - *Cell Phone/economics
MH  - Clinical Competence
MH  - Communication Barriers
MH  - Compensation and Redress
MH  - Cultural Characteristics
MH  - *Developing Countries/economics
MH  - HIV Infections/*drug therapy
MH  - Health Knowledge, Attitudes, Practice
MH  - *Health Resources/economics/organization & administration
MH  - Humans
MH  - Informed Consent
MH  - Language
MH  - *Medication Adherence
MH  - Organizational Objectives
MH  - *Patient Selection/ethics
MH  - *Research Support as Topic/organization & administration
MH  - Single-Blind Method
MH  - Socioeconomic Factors
PMC - PMC3138444
EDAT- 2011/06/11 06:00
MHDA- 2011/09/17 06:00
CRDT- 2011/06/11 06:00
PHST- 2011/02/26 00:00 [received]
PHST- 2011/06/09 00:00 [accepted]
PHST- 2011/06/11 06:00 [entrez]
PHST- 2011/06/11 06:00 [pubmed]
PHST- 2011/09/17 06:00 [medline]
AID - 1745-6215-12-145 [pii]
AID - 10.1186/1745-6215-12-145 [doi]
PST - epublish
SO  - Trials. 2011 Jun 9;12:145. doi: 10.1186/1745-6215-12-145.


PMID- 21657137
OWN - NLM
STAT- MEDLINE
DCOM- 20110630
LR  - 20111117
IS  - 0894-959X (Print)
IS  - 0894-959X (Linking)
VI  - 24
IP  - 2
DP  - 2011 Spring
TI  - Students as vital participants in research projects.
PG  - 66-70
AB  - Inclusion of research coursework into a medical technology or clinical laboratory
      science program is currently viewed as a mark of a good degree program. Examples 
      of this type of coursework are evaluation of scientific papers, techniques of
      scientific writing, application and performance of statistical analysis and
      introduction to research ethics (e.g., Institutional Review Board approval
      process). While many programs have the ability to recruit experienced scientists 
      into research mentorship of medical technology/clinical laboratory science
      students, it is recognized that not all programs have this ability. It is also
      recognized that clinical laboratorians are performing critical diagnostic tests
      and, in this capacity, have the ability to identify research projects that are
      necessary, evidence-based and timely. It is hereby proposed that clinical
      laboratorians take advantage of this innate ability and create rich teaching
      experiences for students by including them in performance of research projects.
      Because of the fact that students are armed with up-to-date knowledge, have
      willing and enthusiastic spirits and are highly motivated to learn, they are
      vital participants in research. The students receive an invaluable active
      learning experience and possibly a future job; the clinical laboratorians meet
      and possibly exceed the research and scholarship expectations of their
      institutions; and the scientific community benefits by the science being shared
      through publication in scientific journals.
FAU - Liddell, Patty W
AU  - Liddell PW
AD  - Basic Science Labs, 1003 Monroe Avenue, Baptist College of Health Sciences,
      Memphis, TN, 38104, USA.
FAU - Heuertz, Rita M
AU  - Heuertz RM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Lab Sci
JT  - Clinical laboratory science : journal of the American Society for Medical
      Technology
JID - 8806547
MH  - Biomedical Research/*education
MH  - *Education, Medical, Undergraduate
MH  - Medical Laboratory Science/*education
MH  - Students, Medical
MH  - United States
EDAT- 2011/06/11 06:00
MHDA- 2011/07/01 06:00
CRDT- 2011/06/11 06:00
PHST- 2011/06/11 06:00 [entrez]
PHST- 2011/06/11 06:00 [pubmed]
PHST- 2011/07/01 06:00 [medline]
PST - ppublish
SO  - Clin Lab Sci. 2011 Spring;24(2):66-70.


PMID- 21657131
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20170214
IS  - 0963-6625 (Print)
IS  - 0963-6625 (Linking)
VI  - 20
IP  - 2
DP  - 2011 Mar
TI  - The National DNA Database on trial: engaging young people in South Wales with
      genetics.
PG  - 146-62
AB  - While there has been research conducted on public views about ethical and social 
      aspects of the National DNA Database (NDNAD), there is little which focuses on
      views of young people, in particular those whose details are held on the NDNAD.
      We describe an engagement activity developed in South Wales to engage young
      offenders with ethical and social issues surrounding the NDNAD--a Mock Trial--and
      how we facilitated the presentation of their views to policy makers. We discuss
      the successes and challenges we encountered with engaging young offenders,
      decisions that the young people reached about possible future policies for the
      NDNAD at the Mock Trial, and their contribution to the decision-making process.
FAU - Anderson, Claudine
AU  - Anderson C
AD  - Kings College, London. andersoncn@cf.ac.uk
FAU - Stackhouse, Rebecca
AU  - Stackhouse R
FAU - Shaw, Anita
AU  - Shaw A
FAU - Iredale, Rachel
AU  - Iredale R
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Public Underst Sci
JT  - Public understanding of science (Bristol, England)
JID - 9306503
MH  - Adolescent
MH  - Attitude
MH  - Child
MH  - Criminals/*psychology
MH  - *Databases, Nucleic Acid
MH  - Humans
MH  - *Policy Making
MH  - Wales
MH  - Young Adult
EDAT- 2011/06/11 06:00
MHDA- 2011/06/29 06:00
CRDT- 2011/06/11 06:00
PHST- 2011/06/11 06:00 [entrez]
PHST- 2011/06/11 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
AID - 10.1177/0963662510375793 [doi]
PST - ppublish
SO  - Public Underst Sci. 2011 Mar;20(2):146-62. doi: 10.1177/0963662510375793.


PMID- 21656657
OWN - NLM
STAT- MEDLINE
DCOM- 20120202
LR  - 20130822
IS  - 1527-6473 (Electronic)
IS  - 1527-6465 (Linking)
VI  - 17 Suppl 2
DP  - 2011 Oct
TI  - Should we use living donor grafts for patients with hepatocellular carcinoma?
      Ethical considerations.
PG  - S128-32
LID - 10.1002/lt.22356 [doi]
FAU - Pomfret, Elizabeth A
AU  - Pomfret EA
AD  - Department of Transplantation and Hepatobiliary Diseases, Lahey Clinic Medical
      Center, Burlington, MA 01805, USA. elizabeth.a.pomfret@lahey.org
FAU - Lodge, J Peter A
AU  - Lodge JP
FAU - Villamil, Federico G
AU  - Villamil FG
FAU - Siegler, Mark
AU  - Siegler M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Liver Transpl
JT  - Liver transplantation : official publication of the American Association for the 
      Study of Liver Diseases and the International Liver Transplantation Society
JID - 100909185
SB  - IM
CIN - Virtual Mentor. 2012 Mar;14(3):215-20. PMID: 23352007
MH  - Carcinoma, Hepatocellular/diagnosis/mortality/*surgery
MH  - Donor Selection/*ethics
MH  - Evidence-Based Medicine
MH  - Health Status Indicators
MH  - Humans
MH  - Liver Neoplasms/diagnosis/mortality/*surgery
MH  - Liver Transplantation/adverse effects/*ethics/mortality
MH  - Living Donors/*ethics
MH  - Patient Selection/*ethics
MH  - Practice Guidelines as Topic
MH  - Risk Assessment
MH  - Risk Factors
MH  - Therapeutic Equipoise
EDAT- 2011/06/10 06:00
MHDA- 2012/02/03 06:00
CRDT- 2011/06/10 06:00
PHST- 2011/06/10 06:00 [entrez]
PHST- 2011/06/10 06:00 [pubmed]
PHST- 2012/02/03 06:00 [medline]
AID - 10.1002/lt.22356 [doi]
PST - ppublish
SO  - Liver Transpl. 2011 Oct;17 Suppl 2:S128-32. doi: 10.1002/lt.22356.


PMID- 21656639
OWN - NLM
STAT- MEDLINE
DCOM- 20130805
LR  - 20151119
IS  - 1522-7278 (Electronic)
IS  - 1520-4081 (Linking)
VI  - 28
IP  - 3
DP  - 2013 Mar
TI  - Prochloraz effects on biomarkers activity in zebrafish early life stages and
      adults.
PG  - 155-63
LID - 10.1002/tox.20710 [doi]
AB  - Zebrafish early life stages (ELS) assays have been increasingly used to assess
      the toxicity of chemicals and waste waters, showing a great potential due to the 
      wide variety of endpoints that can be incorporated in the test. Moreover,
      zebrafish ELS test have been proposed, mainly for ethical reasons, as a surrogate
      for tests with adults. In this work, the fungicide Prochloraz (PCZ) was used as a
      chemical model to compare sensitivities of embryos/larvae and adult zebrafish
      focusing on lethality and biomarkers as endpoints. Effects on embryo development 
      were also assessed. Organization for economic cooperation and development (OECD) 
      guidelines were followed and adapted to include the analyses of the biomarkers
      cholinesterase, glutathione S-transferase, and lactate dehydrogenase. The acute
      toxicity of PCZ for zebrafish ELS and adults seemed to be similar with 96
      h-LC(5)(0) values of 8.5 and 4.6 mg/L, respectively. However, biomarkers were
      only responsive in larvae indicating a higher sensitivity of this life stage at
      sublethal level. PCZ also proved to be teratogenic: at intermediate
      concentrations effects on embryo development could be noticed, including spine
      deformations, edemas, lack of pigmentation, slower heart rate, and complete
      hatching failure. At the lowest concentrations, the more relevant effects (edemas
      and abnormal absorption of the yolk sac) were observed after hatching. The
      measurement of biomarkers in the zebrafish ELS assay seems to a useful tool in
      the detection of chemical effects showing higher sensitivity than adults. Further
      research should focus on the link between biomarkers responses in larvae and
      effects at later life stages of zebrafish.
CI  - Copyright (c) 2011 Wiley Periodicals, Inc.
FAU - Domingues, Ines
AU  - Domingues I
AD  - CESAM-Center for Environmental and Marine Studies & Department of Biology,
      University of Aveiro, 3810-193 Aveiro, Portugal. inesd@ua.pt
FAU - Oliveira, Rhaul
AU  - Oliveira R
FAU - Musso, Carolina
AU  - Musso C
FAU - Cardoso, Marco
AU  - Cardoso M
FAU - Soares, Amadeu M V M
AU  - Soares AM
FAU - Loureiro, Susana
AU  - Loureiro S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110607
PL  - United States
TA  - Environ Toxicol
JT  - Environmental toxicology
JID - 100885357
RN  - 0 (Biomarkers)
RN  - 0 (Fungicides, Industrial)
RN  - 0 (Imidazoles)
RN  - 0 (Teratogens)
RN  - 0 (Water Pollutants, Chemical)
RN  - 99SFL01YCL (prochloraz)
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
RN  - EC 2.5.1.18 (Glutathione Transferase)
RN  - EC 3.1.1.8 (Cholinesterases)
SB  - IM
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Cholinesterases/metabolism
MH  - Embryo, Nonmammalian/drug effects
MH  - Embryonic Development/drug effects
MH  - Fungicides, Industrial/*toxicity
MH  - Glutathione Transferase/metabolism
MH  - Imidazoles/*toxicity
MH  - L-Lactate Dehydrogenase/metabolism
MH  - Larva
MH  - Teratogens/pharmacology
MH  - Water Pollutants, Chemical/toxicity
MH  - Zebrafish/growth & development/*metabolism
EDAT- 2011/06/10 06:00
MHDA- 2013/08/06 06:00
CRDT- 2011/06/10 06:00
PHST- 2010/06/23 00:00 [received]
PHST- 2010/10/20 00:00 [revised]
PHST- 2011/01/28 00:00 [accepted]
PHST- 2011/06/10 06:00 [entrez]
PHST- 2011/06/10 06:00 [pubmed]
PHST- 2013/08/06 06:00 [medline]
AID - 10.1002/tox.20710 [doi]
PST - ppublish
SO  - Environ Toxicol. 2013 Mar;28(3):155-63. doi: 10.1002/tox.20710. Epub 2011 Jun 7.


PMID- 21656291
OWN - NLM
STAT- MEDLINE
DCOM- 20120104
LR  - 20211020
IS  - 1432-1238 (Electronic)
IS  - 0342-4642 (Linking)
VI  - 37
IP  - 9
DP  - 2011 Sep
TI  - Mechanisms of cellular therapy in respiratory diseases.
PG  - 1421-31
LID - 10.1007/s00134-011-2268-3 [doi]
AB  - PURPOSE: Stem cells present a variety of clinical implications in the lungs.
      According to their origin, these cells can be divided into embryonic and adult
      stem cells; however, due to the important ethical and safety limitations that are
      involved in the embryonic stem cell use, most studies have chosen to focus on
      adult stem cell therapy. This article aims to present and clarify the recent
      advances in the field of stem cell biology, as well as to highlight the effects
      of mesenchymal stem cell (MSC) therapy in the context of acute lung injury/acute 
      respiratory distress syndrome and chronic disorders such as lung fibrosis and
      chronic obstructive pulmonary disease. METHODS: For this purpose, we performed a 
      critical review of adult stem cell therapies, covering the main clinical and
      experimental studies published in Pubmed databases in the past 11 years.
      Different characteristics were extracted from these articles, such as: the
      experimental model, strain, cellular type and administration route used as well
      as the positive or negative effects obtained. RESULTS: There is evidence for
      beneficial effects of MSC on lung development, repair, and remodeling. The
      engraftment in the injured lung does not occur easily, but several studies report
      that paracrine factors can be effective in reducing inflammation and promoting
      tissue repair. MSC releases several growth factors and anti-inflammatory
      cytokines that regulate endothelial and epithelial permeability and reduce the
      severity of inflammation. CONCLUSION: A better understanding of the mechanisms
      that control cell division and differentiation, as well as of their paracrine
      effects, is required to enable the optimal use of bone marrow-derived stem cell
      therapy to treat human respiratory diseases.
FAU - Abreu, Soraia C
AU  - Abreu SC
AD  - Laboratorio de Investigacao Pulmonar, Centro de Ciencias da Saude, Instituto de
      Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Avenida
      Carlos Chagas Filho, s/n, Bloco G-014, Ilha do Fundao, Rio de Janeiro, RJ
      21941-902, Brazil.
FAU - Antunes, Mariana A
AU  - Antunes MA
FAU - Pelosi, Paolo
AU  - Pelosi P
FAU - Morales, Marcelo M
AU  - Morales MM
FAU - Rocco, Patricia R M
AU  - Rocco PR
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110609
PL  - United States
TA  - Intensive Care Med
JT  - Intensive care medicine
JID - 7704851
SB  - IM
MH  - Adult Stem Cells/*metabolism/*transplantation
MH  - Bone Marrow Cells
MH  - Fibrosis/therapy
MH  - Humans
MH  - Lung Diseases/*therapy
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Pulmonary Disease, Chronic Obstructive/therapy
MH  - Respiratory Distress Syndrome/therapy
EDAT- 2011/06/10 06:00
MHDA- 2012/01/05 06:00
CRDT- 2011/06/10 06:00
PHST- 2011/02/09 00:00 [received]
PHST- 2011/05/05 00:00 [accepted]
PHST- 2011/06/10 06:00 [entrez]
PHST- 2011/06/10 06:00 [pubmed]
PHST- 2012/01/05 06:00 [medline]
AID - 10.1007/s00134-011-2268-3 [doi]
PST - ppublish
SO  - Intensive Care Med. 2011 Sep;37(9):1421-31. doi: 10.1007/s00134-011-2268-3. Epub 
      2011 Jun 9.


PMID- 21656243
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20191210
IS  - 1612-4790 (Electronic)
IS  - 1612-4782 (Linking)
VI  - 12
IP  - 3
DP  - 2011 Aug
TI  - Autonomy, decisions, and free will.
PG  - 311-3
LID - 10.1007/s10339-011-0409-9 [doi]
AB  - Can humans make decisions? Can machines? What ethical questions arise from using 
      robotics in the education of children? Or in elderly care? These were some of the
      topics of the interdisciplinary college (IK), which took place from the 25th of
      March to the 1st of April in Gunne, next to Lake Mohne. During this one-week
      spring school, more than 40 well-known lecturers from around the globe gave 170
      participants an insight into a cornucopia of topics surrounding "autonomy,
      decisions, and free will".
FAU - von Lautz, Alexander
AU  - von Lautz A
AD  - Saarland University, Saarbrucken, Germany. alexander@vonlautz.de
FAU - Maier, Silvia
AU  - Maier S
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Cogn Process
JT  - Cognitive processing
JID - 101177984
SB  - IM
MH  - Decision Making/*physiology
MH  - Humans
MH  - *Personal Autonomy
MH  - Practice, Psychological
MH  - Robotics
EDAT- 2011/06/10 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/06/10 06:00
PHST- 2011/06/10 06:00 [entrez]
PHST- 2011/06/10 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/s10339-011-0409-9 [doi]
PST - ppublish
SO  - Cogn Process. 2011 Aug;12(3):311-3. doi: 10.1007/s10339-011-0409-9.


PMID- 21656022
OWN - NLM
STAT- MEDLINE
DCOM- 20120905
LR  - 20181201
IS  - 1573-6814 (Electronic)
IS  - 1389-9333 (Linking)
VI  - 13
IP  - 2
DP  - 2012 Jun
TI  - Isolation of three important types of stem cells from the same samples of banked 
      umbilical cord blood.
PG  - 341-51
LID - 10.1007/s10561-011-9262-4 [doi]
AB  - It is known that umbilical cord blood (UCB) is a rich source of stem cells with
      practical and ethical advantages. Three important types of stem cells which can
      be harvested from umbilical cord blood and used in disease treatment are
      hematopoietic stem cells (HSCs), mesenchymal stem cells (MSCs) and endothelial
      progenitor cells (EPCs). Since these stem cells have shown enormous potential in 
      regenerative medicine, numerous umbilical cord blood banks have been established.
      In this study, we examined the ability of banked UCB collected to produce three
      types of stem cells from the same samples with characteristics of HSCs, MSCs and 
      EPCs. We were able to obtain homogeneous plastic rapidly-adherent cells (with
      characteristics of MSCs), slowly-adherent (with characteristics of EPCs) and
      non-adherent cells (with characteristics of HSCs) from the mononuclear cell
      fractions of cryopreserved UCB. Using a protocol of 48 h supernatant
      transferring, we successfully isolated MSCs which expressed CD13, CD44 and CD90
      while CD34, CD45 and CD133 negative, had typical fibroblast-like shape, and was
      able to differentiate into adipocytes; EPCs which were CD34, and CD90 positive,
      CD13, CD44, CD45 and CD133 negative, adherent with cobble-like shape; HSCs which 
      formed colonies when cultured in MethoCult medium.
FAU - Phuc, Pham Van
AU  - Phuc PV
AD  - Laboratory of Stem cell Research and Application, University of Science, Vietnam 
      National University, Ho Chi Minh, Vietnam. pvphuc@hcmuns.edu.vn
FAU - Ngoc, Vu Bich
AU  - Ngoc VB
FAU - Lam, Dang Hoang
AU  - Lam DH
FAU - Tam, Nguyen Thanh
AU  - Tam NT
FAU - Viet, Pham Quoc
AU  - Viet PQ
FAU - Ngoc, Phan Kim
AU  - Ngoc PK
LA  - eng
PT  - Journal Article
DEP - 20110608
PL  - Netherlands
TA  - Cell Tissue Bank
JT  - Cell and tissue banking
JID - 100965121
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adipocytes/cytology
MH  - Biomarkers/metabolism
MH  - Cell Differentiation
MH  - Cell Separation/*methods
MH  - Cells, Cultured
MH  - Colony-Forming Units Assay
MH  - Endothelial Cells/cytology/metabolism
MH  - Fetal Blood/*cytology
MH  - Flow Cytometry
MH  - Hematopoietic Stem Cells/cytology/metabolism
MH  - Humans
MH  - Mesenchymal Stem Cells/cytology/metabolism
MH  - Stem Cells/*cytology/metabolism
MH  - *Tissue Banks
EDAT- 2011/06/10 06:00
MHDA- 2012/09/06 06:00
CRDT- 2011/06/10 06:00
PHST- 2011/02/09 00:00 [received]
PHST- 2011/05/26 00:00 [accepted]
PHST- 2011/06/10 06:00 [entrez]
PHST- 2011/06/10 06:00 [pubmed]
PHST- 2012/09/06 06:00 [medline]
AID - 10.1007/s10561-011-9262-4 [doi]
PST - ppublish
SO  - Cell Tissue Bank. 2012 Jun;13(2):341-51. doi: 10.1007/s10561-011-9262-4. Epub
      2011 Jun 8.


PMID- 21655874
OWN - NLM
STAT- MEDLINE
DCOM- 20111209
LR  - 20190918
IS  - 1677-9487 (Electronic)
IS  - 0004-2730 (Linking)
VI  - 55
IP  - 3
DP  - 2011 Apr
TI  - [Extreme subcutaneous and intramuscular insulin resistance at type 1 diabetes
      mellitus].
PG  - 233-7
LID - S0004-27302011000300010 [pii]
AB  - Insulin resistance signs reduced cellular response to this hormone and
      dysfunction of glucose transport to intracellular compartment. This phenomenon is
      associated to genetic factors and principally behavior factors correlating to
      obesity and its comorbidities, as type 2 diabetes mellitus, hypertension and
      dyslipidemia. However clinical factors of insulin resistance are still present at
      not obese type 1 diabetes in a known syndrome called type 1 diabetes mellitus
      with resistance to insulin administered subcutaneously and intramuscularly
      (DRIASM). This is a rare condition that consists into insulin resistance at
      subcutaneously and intramuscularly use and normal or near to normal sensitivity
      at intravenously way. Treatments until now proposed are ineffective and are
      related to frequent fails and complications. We report here two cases of DRIASM
      in 45 and 46 female patients that are different from others yet related because
      they have late diabetes type 1, sustained hyperglycemia associated to catabolic, 
      microangiopathy and neuropathic complications without any ketoacidosis episode.
      The treatment vary from alternative ways for insulin infusion to inscription to a
      possible performance of pancreas transplantation like a experiment of definitive 
      treatment. This report was approved by Research Ethic Committee from Sao Jose do 
      Rio Preto medical school.
FAU - Pinheiro, Anielli
AU  - Pinheiro A
AD  - Disciplina de Endocrinologia e Metabologia, Faculdade de Medicina de Sao Jose do 
      Rio Preto, SP, Brasil. anielli.pinheiro@yahoo.com
FAU - Tacito, Lucia H B
AU  - Tacito LH
FAU - Pires, Antonio C
AU  - Pires AC
LA  - por
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - Extrema resistencia a insulina subcutanea e intramuscular em diabetes melito tipo
      1.
PL  - Brazil
TA  - Arq Bras Endocrinol Metabol
JT  - Arquivos brasileiros de endocrinologia e metabologia
JID - 0403437
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
SB  - IM
MH  - Diabetes Mellitus, Type 1/*drug therapy/metabolism
MH  - Female
MH  - Humans
MH  - Hypoglycemic Agents/*administration & dosage
MH  - Injections, Intramuscular
MH  - Injections, Subcutaneous
MH  - Insulin/*administration & dosage
MH  - *Insulin Resistance
MH  - Middle Aged
EDAT- 2011/06/10 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/06/10 06:00
PHST- 2010/10/25 00:00 [received]
PHST- 2011/03/14 00:00 [accepted]
PHST- 2011/06/10 06:00 [entrez]
PHST- 2011/06/10 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - S0004-27302011000300010 [pii]
AID - 10.1590/s0004-27302011000300010 [doi]
PST - ppublish
SO  - Arq Bras Endocrinol Metabol. 2011 Apr;55(3):233-7. doi:
      10.1590/s0004-27302011000300010.


PMID- 21655655
OWN - NLM
STAT- MEDLINE
DCOM- 20110928
LR  - 20161125
IS  - 2066-8279 (Electronic)
IS  - 1220-0522 (Linking)
VI  - 52
IP  - 2
DP  - 2011
TI  - Power Doppler sonography, a non-invasive method of assessment of the synovial
      inflammation in patients with early rheumatoid arthritis.
PG  - 637-43
AB  - OBJECTIVE: To detect synovitis is important in both the diagnosis and outcome
      assessment of early rheumatoid arthritis. This study was meant to assess the
      validity and reproducibility of ultrasonography (US) as a mean of detection for
      the knee synovitis, by comparing US findings with clinical examination and
      histopathological findings in synovial membrane. METHODS: The study group
      included 65 patients with early rheumatoid arthritis - below 12 months from the
      debut, naive for DMARDs, in whom demographic data - gender, age, disease
      duration, the number of tender and swollen joints, HAQ score (Health Assessment
      Questionnaire) and serum samples for CRP, RF, anti-CCP2 antibodies (ELISA, QUANTA
      LiteTM, CCP IgG, INOVA Diagnostics Inc, USA), VEGF (ELISA, VEGF2, DRG
      International, IRC, USA) determination were recorded. Disease Activity Score for 
      28 joints (DAS28) was calculated. PDS signal was scored from 0 to 3 according to 
      the overall expression of PDS findings at the knees. A sample of synovial tissue 
      was obtained in 35 patients during the arthroscopy, and the vascularisation of
      the synovial tissue was evaluated by immunohistochemistry and was analyzed
      qualitatively by a pathologist who was unaware of the PDS findings. Written,
      informed consent was obtained from each patient before entering the study. They
      all had active synovitis of the knee, ultrasonographically confirmed, with the
      identification of the target biopsy sites. The study was approved by the Ethics
      Committee of the University of Medicine and Pharmacy of Craiova. RESULTS:
      Angiogenesis was evaluated and quantified by immunohistochemical evaluation of
      synovial VEGF, one of the most specific endothelial growing factors, that proved 
      to correlate significantly with the serum levels of VEGF, DAS28 as well as with
      the power Doppler sonography (PDS) score. CONCLUSIONS: The statistical analysis
      of the data showed that PDS could be used as non-invasive marker with predictive 
      value regarding synovial inflammation and disease progression in early forms of
      the disease as well as a useful method in the assessment of the therapeutic
      response.
FAU - Vreju, Fl
AU  - Vreju F
AD  - Department of Rheumatology, University of Medicine and Pharmacy of Craiova,
      Romania. florin_vreju@yahoo.com
FAU - Ciurea, M
AU  - Ciurea M
FAU - Rosu, Anca
AU  - Rosu A
FAU - Musetescu, Anca
AU  - Musetescu A
FAU - Grecu, D
AU  - Grecu D
FAU - Ciurea, Paulina
AU  - Ciurea P
LA  - eng
PT  - Journal Article
PL  - Romania
TA  - Rom J Morphol Embryol
JT  - Romanian journal of morphology and embryology = Revue roumaine de morphologie et 
      embryologie
JID - 9112454
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-1)
SB  - IM
MH  - Arthritis, Rheumatoid/*diagnostic imaging/*pathology
MH  - Demography
MH  - Endothelial Cells/pathology
MH  - Female
MH  - Fibroblasts/pathology
MH  - Humans
MH  - Inflammation/*diagnostic imaging/*pathology
MH  - Male
MH  - Middle Aged
MH  - Synovial Membrane/*diagnostic imaging/*pathology
MH  - Ultrasonography, Doppler/*methods
MH  - Vascular Endothelial Growth Factor A/metabolism
MH  - Vascular Endothelial Growth Factor Receptor-1/metabolism
EDAT- 2011/06/10 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/06/10 06:00
PHST- 2011/06/10 06:00 [entrez]
PHST- 2011/06/10 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 520211637643 [pii]
PST - ppublish
SO  - Rom J Morphol Embryol. 2011;52(2):637-43.


PMID- 21655494
OWN - NLM
STAT- MEDLINE
DCOM- 20120105
LR  - 20110609
IS  - 0300-8495 (Print)
IS  - 0300-8495 (Linking)
VI  - 40
IP  - 6
DP  - 2011 Jun
TI  - Electronic care plans and medicolegal liability.
PG  - 432-4
AB  - BACKGROUND: Government policy encourages the use of care plans in general
      practice, and developments in information technology have the potential to
      facilitate their use via a shared electronic care plan. Sharing a comprehensive
      set of patient data raises privacy issues and questions about the nature and
      extent of potential liability. METHODS: A round table discussion was held with
      participants purposively selected for expertise in their fields. RESULTS:
      Consensus stressed the privacy dangers inherent in the creation of a shared
      electronic care plan accessible by multiple treating professionals and a private 
      sector intermediary information technology provider, and the difficulties in
      ensuring appropriate informed consent is provided by patients. DISCUSSION: As the
      use of shared electronic care plans increases in Australia, new legal and ethical
      issues may emerge which need to be understood and addressed if general
      practitioners and other healthcare team members are to be able to participate
      with confidence.
FAU - Paterson, Moira
AU  - Paterson M
AD  - Faculty of Law, Monash University, Melbourne, Victoria, Australia.
      moira.paterson@monash.edu
FAU - Jones, Kay
AU  - Jones K
FAU - Schattner, Peter
AU  - Schattner P
FAU - Adaji, Akuh
AU  - Adaji A
FAU - Piterman, Leon
AU  - Piterman L
LA  - eng
PT  - Consensus Development Conference
PT  - Journal Article
PL  - Australia
TA  - Aust Fam Physician
JT  - Australian family physician
JID - 0326701
SB  - IM
MH  - Australia
MH  - *Confidentiality
MH  - *Electronic Health Records/ethics/legislation & jurisprudence
MH  - *General Practice
MH  - Humans
MH  - Information Dissemination
MH  - *Liability, Legal
MH  - *Patient Care Planning
EDAT- 2011/06/10 06:00
MHDA- 2012/01/06 06:00
CRDT- 2011/06/10 06:00
PHST- 2011/06/10 06:00 [entrez]
PHST- 2011/06/10 06:00 [pubmed]
PHST- 2012/01/06 06:00 [medline]
PST - ppublish
SO  - Aust Fam Physician. 2011 Jun;40(6):432-4.


PMID- 21655317
OWN - NLM
STAT- MEDLINE
DCOM- 20110928
LR  - 20211020
IS  - 1549-1676 (Electronic)
IS  - 1549-1277 (Linking)
VI  - 8
IP  - 5
DP  - 2011 May
TI  - The impact of retail-sector delivery of artemether-lumefantrine on malaria
      treatment of children under five in Kenya: a cluster randomized controlled trial.
PG  - e1000437
LID - 10.1371/journal.pmed.1000437 [doi]
AB  - BACKGROUND: It has been proposed that artemisinin-based combination therapy (ACT)
      be subsidised in the private sector in order to improve affordability and access.
      This study in western Kenya aimed to evaluate the impact of providing subsidized 
      artemether-lumefantrine (AL) through retail providers on the coverage of prompt, 
      effective antimalarial treatment for febrile children aged 3-59 months. METHODS
      AND FINDINGS: We used a cluster-randomized, controlled design with nine control
      and nine intervention sublocations, equally distributed across three districts in
      western Kenya. Cross-sectional household surveys were conducted before and after 
      the delivery of the intervention. The intervention comprised provision of
      subsidized packs of paediatric ACT to retail outlets, training of retail outlet
      staff, and community awareness activities. The primary outcome was defined as the
      proportion of children aged 3-59 months reporting fever in the past 2 weeks who
      started treatment with AL on the same day or following day of fever onset. Data
      were collected using structured questionnaires and analyzed based on
      cluster-level summaries, comparing control to intervention arms, while adjusting 
      for other covariates. Data were collected on 2,749 children in the target age
      group at baseline and 2,662 at follow-up. 29% of children experienced fever
      within 2 weeks before the interview. At follow-up, the percentage of children
      receiving AL on the day of fever or the following day had risen by 14.6% points
      in the control arm (from 5.3% [standard deviation (SD): 3.2%] to 19.9% [SD:
      10.0%]) and 40.2% points in the intervention arm (from 4.7% [SD: 3.4%] to 44.9%
      [SD: 11.7%]). The percentage of children receiving AL was significantly greater
      in the intervention arm at follow-up, with a difference between the arms of 25.0%
      points (95% confidence interval [CI]: 14.1%, 35.9%; unadjusted p = 0.0002,
      adjusted p = 0.0001). No significant differences were observed between arms in
      the proportion of caregivers who sought treatment for their child's fever by
      source, or in the child's adherence to AL. CONCLUSIONS: Subsidizing ACT in the
      retail sector can significantly increase ACT coverage for reported fevers in
      rural areas. Further research is needed on the impact and cost-effectiveness of
      such subsidy programmes at a national scale. TRIAL REGISTRATION: Current
      Controlled Trials ISRCTN59275137 and Kenya Pharmacy and Poisons Board Ethical
      Committee for Clinical Trials PPB/ECCT/08/07.
FAU - Kangwana, Beth P
AU  - Kangwana BP
AD  - Malaria Public Health & Epidemiology Group, Kenya Medical Research
      Institute-Wellcome Trust Research Programme, Kenya.
      bkangwana@nairobi.kemri-wellcome.org
FAU - Kedenge, Sarah V
AU  - Kedenge SV
FAU - Noor, Abdisalan M
AU  - Noor AM
FAU - Alegana, Victor A
AU  - Alegana VA
FAU - Nyandigisi, Andrew J
AU  - Nyandigisi AJ
FAU - Pandit, Jayesh
AU  - Pandit J
FAU - Fegan, Greg W
AU  - Fegan GW
FAU - Todd, James E
AU  - Todd JE
FAU - Brooker, Simon
AU  - Brooker S
FAU - Snow, Robert W
AU  - Snow RW
FAU - Goodman, Catherine A
AU  - Goodman CA
LA  - eng
SI  - ISRCTN/ISRCTN59275137
GR  - 079080/WT_/Wellcome Trust/United Kingdom
GR  - WT_/Wellcome Trust/United Kingdom
GR  - 0811673/WT_/Wellcome Trust/United Kingdom
GR  - 081829/WT_/Wellcome Trust/United Kingdom
GR  - 079081/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20110531
PL  - United States
TA  - PLoS Med
JT  - PLoS medicine
JID - 101231360
RN  - 0 (Antimalarials)
RN  - 0 (Artemether, Lumefantrine Drug Combination)
RN  - 0 (Artemisinins)
RN  - 0 (Drug Combinations)
RN  - 0 (Ethanolamines)
RN  - 0 (Fluorenes)
SB  - IM
MH  - Antimalarials/economics/supply & distribution/*therapeutic use
MH  - Artemether, Lumefantrine Drug Combination
MH  - Artemisinins/economics/supply & distribution/*therapeutic use
MH  - Child, Preschool
MH  - Cost-Benefit Analysis
MH  - Cross-Sectional Studies
MH  - Drug Combinations
MH  - Ethanolamines/economics/supply & distribution/*therapeutic use
MH  - Female
MH  - Fluorenes/economics/supply & distribution/*therapeutic use
MH  - Health Services Accessibility
MH  - Humans
MH  - Infant
MH  - Kenya/epidemiology
MH  - Malaria, Falciparum/*drug therapy/epidemiology/parasitology
MH  - Male
MH  - Plasmodium falciparum/drug effects
MH  - Private Sector
MH  - *Rural Health Services
MH  - Rural Population
MH  - Treatment Outcome
PMC - PMC3104978
EDAT- 2011/06/10 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/06/10 06:00
PHST- 2010/08/12 00:00 [received]
PHST- 2011/04/18 00:00 [accepted]
PHST- 2011/06/10 06:00 [entrez]
PHST- 2011/06/10 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 10.1371/journal.pmed.1000437 [doi]
AID - 10-PLME-RA-5891R3 [pii]
PST - ppublish
SO  - PLoS Med. 2011 May;8(5):e1000437. doi: 10.1371/journal.pmed.1000437. Epub 2011
      May 31.


PMID- 21655146
OWN - NLM
STAT- MEDLINE
DCOM- 20110926
LR  - 20211020
IS  - 1660-4601 (Electronic)
IS  - 1660-4601 (Linking)
VI  - 8
IP  - 5
DP  - 2011 May
TI  - Comparing distributions of environmental outcomes for regulatory environmental
      justice analysis.
PG  - 1707-26
LID - 10.3390/ijerph8051707 [doi]
AB  - Economists have long been interested in measuring distributional impacts of
      policy interventions. As environmental justice (EJ) emerged as an ethical issue
      in the 1970s, the academic literature has provided statistical analyses of the
      incidence and causes of various environmental outcomes as they relate to race,
      income, and other demographic variables. In the context of regulatory impacts,
      however, there is a lack of consensus regarding what information is relevant for 
      EJ analysis, and how best to present it. This paper helps frame the discussion by
      suggesting a set of questions fundamental to regulatory EJ analysis, reviewing
      past approaches to quantifying distributional equity, and discussing the
      potential for adapting existing tools to the regulatory context.
FAU - Maguire, Kelly
AU  - Maguire K
AD  - National Center for Environmental Economics, US Environmental Protection Agency, 
      1200 Pennsylvania Ave, NW, MC 1809T, Washington, DC 20460, USA.
      maguire.kelly@epa.gov
FAU - Sheriff, Glenn
AU  - Sheriff G
LA  - eng
PT  - Journal Article
DEP - 20110524
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
SB  - IM
MH  - *Environmental Policy
MH  - *Social Justice
MH  - *Statistics as Topic
MH  - Vulnerable Populations
PMC - PMC3108136
OTO - NOTNLM
OT  - *distributional analysis
OT  - *environmental justice
OT  - *equity
OT  - *inequality index
OT  - *regulatory impact analysis
EDAT- 2011/06/10 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/06/10 06:00
PHST- 2011/04/19 00:00 [received]
PHST- 2011/05/10 00:00 [revised]
PHST- 2011/05/12 00:00 [accepted]
PHST- 2011/06/10 06:00 [entrez]
PHST- 2011/06/10 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 10.3390/ijerph8051707 [doi]
AID - ijerph8051707 [pii]
PST - ppublish
SO  - Int J Environ Res Public Health. 2011 May;8(5):1707-26. doi:
      10.3390/ijerph8051707. Epub 2011 May 24.


PMID- 21654969
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 2231-2714 (Electronic)
IS  - 0973-6131 (Linking)
VI  - 4
IP  - 1
DP  - 2011 Jan
TI  - Effect of yoga on mental health: Comparative study between young and senior
      subjects in Japan.
PG  - 7-12
LID - 10.4103/0973-6131.78173 [doi]
AB  - BACKGROUND: Japan has a large number of senior citizens. Yoga can be wisely
      applied in old age care. There is no any age restriction to practice yoga. The
      effect may differ by age. There is a need to study the mechanism of action of
      yoga with respect to age. AIM: This study was conducted in Japan to find the
      effect of yoga on mental health between young and senior people. MATERIALS AND
      METHODS: Twenty-five normal healthy volunteers of both sexes were divided into
      two groups according to age. Fifteen participants of the age group between 65 to 
      75 years and 10 participants of the age group between 20 to 30 years were
      selected. This study was approved by the ethical committee of Kawasaki University
      of Medical Welfare. Selected individuals were subjected to 90 min of yoga classes
      once or twice a week for a month. Salivary amylase activity was assessed before
      and after yoga practice. State Trait Anxiety Inventory (STAI) was given before
      yoga on the first day and after one month of practice to assess the change in
      State anxiety and Trait anxiety. RESULTS: Senior group - Salivary amylase
      activity decreased from 111.2+/-42.7 to 83.48+/-39.5 kU/L [average+/-standard
      deviation]. Younger group - Salivary amylase activity reduced from 60.74+/-31.8
      to 42.39+/-24 kU/L. Senior group - State anxiety score decreased from 41.13
      +/-8.43 to 30.8+/-6.49, Trait anxiety score reduced from 45.66+/-7.5 to
      40.73+/-8.3. Younger group - State anxiety score reduced from 38.7+/-4.8 to
      30.8+/-4.1,Trait anxiety score reduced from 46.2+/-7.9 to 42.9+/-9.1. Changes
      were statistically significant with P<0.05. CONCLUSION: Decrease in Salivary
      amylase activity may be due to reduction in sympathetic response. Reduction in
      State and Trait anxiety score signifies that yoga has both immediate as well as
      long-term effect on anxiety reduction. Thus yoga helps to improve the mental
      health in both the groups.
FAU - Gururaja, Derebail
AU  - Gururaja D
AD  - Department of Medical Welfare, Kawasaki University of Medical Welfare, Okayama,
      Japan.
FAU - Harano, Kaori
AU  - Harano K
FAU - Toyotake, Ikenaga
AU  - Toyotake I
FAU - Kobayashi, Haruo
AU  - Kobayashi H
LA  - eng
PT  - Journal Article
PL  - India
TA  - Int J Yoga
JT  - International journal of yoga
JID - 101313247
PMC - PMC3099103
OTO - NOTNLM
OT  - Salivary amylase activity
OT  - state trait anxiety inventory
OT  - stress
OT  - yoga
EDAT- 2011/06/10 06:00
MHDA- 2011/06/10 06:01
CRDT- 2011/06/10 06:00
PHST- 2011/06/10 06:00 [entrez]
PHST- 2011/06/10 06:00 [pubmed]
PHST- 2011/06/10 06:01 [medline]
AID - 10.4103/0973-6131.78173 [doi]
AID - IJY-4-7 [pii]
PST - ppublish
SO  - Int J Yoga. 2011 Jan;4(1):7-12. doi: 10.4103/0973-6131.78173.


PMID- 21654533
OWN - NLM
STAT- MEDLINE
DCOM- 20120104
LR  - 20161018
IS  - 1533-4287 (Electronic)
IS  - 1064-8011 (Linking)
VI  - 25
IP  - 9
DP  - 2011 Sep
TI  - Effect of postactivation potentiation on swimming starts in international sprint 
      swimmers.
PG  - 2418-23
LID - 10.1519/JSC.0b013e318201bf7a [doi]
AB  - The aim of this study was to investigate the effects of postactivation
      potentiation (PAP) on swim start performance (time to 15 m) in a group of
      international sprint swimmers. Nine international sprint swimmers (7 men and 2
      women) volunteered and gave informed consent for this study, which was approved
      by the university ethics committee. Initially, swimmers performed a
      countermovement jump (CMJ) on a portable force platform (FP) at baseline and at
      the following time points approximately 15 seconds, 4, 8, 12, and 16 minutes
      after a PAP stimulus (1 set of 3 repetitions at 87% 1 repetition maximum [RM]) to
      individually determine the recovery time required to observe enhanced muscle
      performance. On 2 additional days, swimmers performed a swim start to 15 m under 
      50-m freestyle race conditions, which was preceded by either their individualized
      race specific warm-up or a PAP stimulus (1 set of 3 repetitions at 87% 1RM). Both
      trials were recorded on 2 cameras operating at 50 Hz with camera 1 located at the
      start and camera 2 at the 15-m mark. Peak vertical force (PVF) and peak
      horizontal force (PHF) were measured during all swim starts from a portable FP
      placed on top of the swim block. A repeated measures analysis of variance
      revealed a significant time effect with regard to power output (PO) (F = 20.963, 
      p < 0.01) and jump height (JH) (F = 14.634, p < 0.01) with a paired comparison
      indicating a significant increase in PO and JH after 8 minutes of recovery from
      the PAP stimulus. There was a significant increase in both PHF and PVF after the 
      PAP stimulus compared to the swim-specific warm-up during the swim start (PHF 770
      +/- 228 vs. 814 +/- 263 N, p = 0.018; PVF: 1,462 +/- 280 vs. 1,518 +/- 311 N, p =
      0.038); however, time to 15 m was the same when both starts were compared (7.1
      +/- 0.8 vs. 7.1 +/- 0.8 seconds, p = 0.447). The results from this study indicate
      that muscle performance during a CMJ is enhanced after a PAP stimulus providing
      adequate recovery ( approximately 8 minutes) is given between the 2 activities.
      In addition, this study demonstrated that swimmers performed equally well in
      terms of time to 15 m when a PAP stimulus was compared to their individualized
      race specific warm-up and indicates that PAP may be a useful addition to a
      warm-up protocol before races. However, more research is required to fully
      understand the role PAP plays in swim performance.
FAU - Kilduff, Liam P
AU  - Kilduff LP
AD  - Sport and Exercise Science Research Center, Swansea University, Swansea, United
      Kingdom. I.kilduff@swansea.ac.uk
FAU - Cunningham, Dan J
AU  - Cunningham DJ
FAU - Owen, Nick J
AU  - Owen NJ
FAU - West, Daniel J
AU  - West DJ
FAU - Bracken, Richard M
AU  - Bracken RM
FAU - Cook, Christian J
AU  - Cook CJ
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - J Strength Cond Res
JT  - Journal of strength and conditioning research
JID - 9415084
SB  - IM
MH  - Athletic Performance/*physiology
MH  - Exercise/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Muscle Strength/physiology
MH  - Muscle, Skeletal/physiology
MH  - Swimming/*physiology
MH  - Young Adult
EDAT- 2011/06/10 06:00
MHDA- 2012/01/05 06:00
CRDT- 2011/06/10 06:00
PHST- 2011/06/10 06:00 [entrez]
PHST- 2011/06/10 06:00 [pubmed]
PHST- 2012/01/05 06:00 [medline]
AID - 10.1519/JSC.0b013e318201bf7a [doi]
PST - ppublish
SO  - J Strength Cond Res. 2011 Sep;25(9):2418-23. doi: 10.1519/JSC.0b013e318201bf7a.


PMID- 21654376
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20220330
IS  - 1538-9782 (Electronic)
IS  - 0887-6274 (Linking)
VI  - 25
IP  - 4
DP  - 2011 Jul-Aug
TI  - A journey to patient-centered care in Ontario, Canada: implementation of a
      best-practice guideline.
PG  - 198-206
LID - 10.1097/NUR.0b013e318221f506 [doi]
AB  - PURPOSE: This article describes the process undertaken to implement the
      Best-Practice Guideline on Client (patient)-centered care. Curriculum
      development, the application of theoretical frameworks, and the use of a variety 
      of models for care and learning are described. Clinical nurse specialists
      demonstrated successful curriculum development, facilitation, and research uptake
      by participants. BACKGROUND: As a Canadian teaching hospital, we are committed to
      promoting a variety of evidence-based practice guidelines that are systematically
      developed and framed around a core set of values consistent with our ethical
      frameworks and based on current research and theories. Many guidelines are
      prescriptive; however, this particular guideline posed challenges because of its 
      conceptual and philosophical nature. DESCRIPTION: Challenges of curriculum
      development were resolved using the "know-do-be" framework and "proximity" as the
      element of the caring component of patient-centered care. Elements of narrative
      theory and inclusion of nursing and other experiential learning models were
      utilized. Competing corporate initiatives that linked with client-centered care
      were included. OUTCOMES: The process resulted in the development of a 12-week
      course entitled "The Telling Stories of our Practice-Client-Centered Care."
      Evidence of sustainability and spread of this best-practice guideline to other
      corporate initiatives through research, patient safety workshops, nursing staff
      orientation, and other educational activities focusing on professionalism,
      quality of work life, and falls prevention is described. CONCLUSIONS: Clinical
      nurses specialists and other advanced practice nurses demonstrated clinical
      competencies in initiating changes that resulted in increased use of
      evidence-based practice.
FAU - Ford, Patricia Elizabeth Ann
AU  - Ford PE
AD  - McMaster University, St Joseph's Healthcare Hamilton, 50 Charlton Ave. E,
      Hamilton, Ontario, Canada. pford@stjoes.ca
FAU - Rolfe, Steven
AU  - Rolfe S
FAU - Kirkpatrck, Helen
AU  - Kirkpatrck H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Nurse Spec
JT  - Clinical nurse specialist CNS
JID - 8709115
MH  - Curriculum
MH  - Evidence-Based Medicine/*organization & administration
MH  - Hospitals, Teaching/*organization & administration
MH  - Humans
MH  - Models, Nursing
MH  - Nurse Clinicians
MH  - Ontario
MH  - Patient-Centered Care/*organization & administration
MH  - *Practice Guidelines as Topic
EDAT- 2011/06/10 06:00
MHDA- 2011/10/25 06:00
CRDT- 2011/06/10 06:00
PHST- 2011/06/10 06:00 [entrez]
PHST- 2011/06/10 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
AID - 10.1097/NUR.0b013e318221f506 [doi]
AID - 00002800-201107000-00010 [pii]
PST - ppublish
SO  - Clin Nurse Spec. 2011 Jul-Aug;25(4):198-206. doi: 10.1097/NUR.0b013e318221f506.


PMID- 21654182
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20181201
IS  - 1661-7819 (Electronic)
IS  - 1661-7800 (Linking)
VI  - 100
IP  - 2
DP  - 2011
TI  - A time to be born and a time to die: ethical challenges in the neonatal intensive
      care unit.
PG  - 215-6
LID - 10.1159/000329089 [doi]
FAU - Saugstad, Ola Didrik
AU  - Saugstad OD
AD  - Department of Pediatric Research, Oslo University Hospital, Rikshospitalet,
      University of Oslo, Oslo, Norway. odsaugstad@rr-research.no
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20110603
PL  - Switzerland
TA  - Neonatology
JT  - Neonatology
JID - 101286577
SB  - IM
CON - Neonatology. 2011;100(2):206-14. PMID: 21471705
MH  - Decision Making/*ethics
MH  - Humans
MH  - *Neonatology
MH  - *Societies, Medical
MH  - Terminal Care/*trends
EDAT- 2011/06/10 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/06/10 06:00
PHST- 2011/04/30 00:00 [received]
PHST- 2011/04/30 00:00 [accepted]
PHST- 2011/06/10 06:00 [entrez]
PHST- 2011/06/10 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - 000329089 [pii]
AID - 10.1159/000329089 [doi]
PST - ppublish
SO  - Neonatology. 2011;100(2):215-6. doi: 10.1159/000329089. Epub 2011 Jun 3.


PMID- 21653648
OWN - NLM
STAT- MEDLINE
DCOM- 20120103
LR  - 20110620
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 7
DP  - 2011 Jul
TI  - Some Jewish thoughts on genetic enhancement.
PG  - 415-9
LID - 10.1136/jme.2009.034744 [doi]
AB  - The issues of the ethics of germ line modification in general and of enhancement 
      by germ line modification in particular have been the subject of hundreds of
      articles in the bioethical literature. Both because the techniques are far from
      perfected and because the potential long term side effects are unkown, there is a
      widespread consensus that germ line modification for enhancement is absolutely
      unethical and beyond the pale at the present time. The author considers a thought
      expperiment projecting into the future in which perhaps the safety and
      reversibility of germ line modification have been clearly demonstrated. Under
      such circumstances it is contended that the dividing line between treatment and
      enhancement is difficult and indeed perhaps impossible to maintain. The Jewish
      tradition is examined and from the various sources cited it would seem that the
      benefits of certain kinds of genetic enhancements might well outweigh the
      objections to such manipulations.
FAU - Glick, Shimon M
AU  - Glick SM
AD  - Jakobovits Center for Jewish Medical Ethics, Faculty of Health Sciences, Ben
      Gurion University of the Negev, Beer Sheva, Israel. gshimon@bgu.ac.il
LA  - eng
PT  - Journal Article
DEP - 20110608
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Genetic Engineering/*ethics
MH  - Genetic Enhancement/*ethics
MH  - Genetic Predisposition to Disease
MH  - Genetic Research/ethics
MH  - Humans
MH  - *Judaism
MH  - *Religion and Medicine
EDAT- 2011/06/10 06:00
MHDA- 2012/01/04 06:00
CRDT- 2011/06/10 06:00
PHST- 2011/06/10 06:00 [entrez]
PHST- 2011/06/10 06:00 [pubmed]
PHST- 2012/01/04 06:00 [medline]
AID - jme.2009.034744 [pii]
AID - 10.1136/jme.2009.034744 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Jul;37(7):415-9. doi: 10.1136/jme.2009.034744. Epub 2011 Jun
      8.


PMID- 21653262
OWN - NLM
STAT- MEDLINE
DCOM- 20111102
LR  - 20181201
IS  - 1943-3662 (Electronic)
IS  - 1093-6793 (Linking)
VI  - 39
IP  - 2
DP  - 2011
TI  - Commentary: Challenges in providing psychiatric disability evaluations.
PG  - 189-93
AB  - Christopher et al., in their study of differences between general psychiatrists
      and forensic psychiatrists in the evaluation of psychiatric disability relative
      to Social Security Disability Insurance claims, have provided useful information 
      regarding statistically significant differences in practice and beliefs. Despite 
      the relatively small number of participants in this unique survey study, the
      authors have identified important sources of potential bias among both general
      and forensic psychiatrists. The study also highlights the profound disconnect
      between the historically prevalent medical model of disability, in which treating
      clinicians are considered experts in assessing disability, and the actuality that
      most general and forensic psychiatrists lack training in disability evaluations. 
      This misperception creates additional practical and ethics-related problems for
      clinicians when their patients file disability claims.
FAU - Gold, Liza H
AU  - Gold LH
AD  - Georgetown University School of Medicine, Washington, DC, USA. lhgoldmd@gmail.com
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - J Am Acad Psychiatry Law
JT  - The journal of the American Academy of Psychiatry and the Law
JID - 9708963
SB  - IM
CON - J Am Acad Psychiatry Law. 2011;39(2):183-8. PMID: 21653261
MH  - *Disability Evaluation
MH  - *Forensic Psychiatry
MH  - Humans
EDAT- 2011/06/10 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/06/10 06:00
PHST- 2011/06/10 06:00 [entrez]
PHST- 2011/06/10 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
AID - 39/2/189 [pii]
PST - ppublish
SO  - J Am Acad Psychiatry Law. 2011;39(2):189-93.


PMID- 21653261
OWN - NLM
STAT- MEDLINE
DCOM- 20111102
LR  - 20151119
IS  - 1943-3662 (Electronic)
IS  - 1093-6793 (Linking)
VI  - 39
IP  - 2
DP  - 2011
TI  - Evaluating psychiatric disability: differences by forensic expertise.
PG  - 183-8
AB  - The task of evaluating psychiatric disability poses several ethics-related and
      practical challenges for psychiatrists, especially when they are responding to a 
      request from a third party for a disability evaluation on their own patient. This
      study sought to evaluate the differences in how forensic and nonforensic
      psychiatrists approach and view evaluations for Social Security disability
      benefits. Thirty-two forensic and 75 nonforensic psychiatrists were surveyed on
      their practice patterns and perceptions of role, objectivity, and dual agency in 
      the disability evaluation process. Significant differences were found between
      forensic and nonforensic psychiatrists' perceptions of the dual-agency conflict, 
      beliefs about who should perform evaluations, and beliefs about the weight given 
      to different opinions when decisions of whether to award disability benefits are 
      made. A minority of respondents in both groups reported having identified a
      patient as disabled, despite believing otherwise. The implications of these
      findings are discussed.
FAU - Christopher, Paul P
AU  - Christopher PP
AD  - Department of Psychiatry, University of Massachusetts Medical School, Worcester, 
      MA 01655, USA. paul.christopher@umassmed.edu
FAU - Arikan, Rasim
AU  - Arikan R
FAU - Pinals, Debra A
AU  - Pinals DA
FAU - Fisher, William H
AU  - Fisher WH
FAU - Appelbaum, Paul S
AU  - Appelbaum PS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Acad Psychiatry Law
JT  - The journal of the American Academy of Psychiatry and the Law
JID - 9708963
SB  - IM
CIN - J Am Acad Psychiatry Law. 2011;39(2):189-93. PMID: 21653262
CIN - J Am Acad Psychiatry Law. 2011;39(2):194-6. PMID: 21653263
MH  - *Disability Evaluation
MH  - *Forensic Psychiatry
MH  - Humans
MH  - Practice Patterns, Physicians'
MH  - Surveys and Questionnaires
EDAT- 2011/06/10 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/06/10 06:00
PHST- 2011/06/10 06:00 [entrez]
PHST- 2011/06/10 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
AID - 39/2/183 [pii]
PST - ppublish
SO  - J Am Acad Psychiatry Law. 2011;39(2):183-8.


PMID- 21653257
OWN - NLM
STAT- MEDLINE
DCOM- 20111102
LR  - 20181201
IS  - 1943-3662 (Electronic)
IS  - 1093-6793 (Linking)
VI  - 39
IP  - 2
DP  - 2011
TI  - Commentary: Boundary violations in the correctional versus therapeutic
      setting--are the standards the same?
PG  - 164-5
AB  - Education and training provide psychotherapists with tools for self-awareness
      which help to prevent boundary violations. Corrections officers are not similarly
      equipped and therefore should not be held to the same standard, particularly when
      they are being subjected to abuse and intimidation. While it is important to
      understand gender-specific patterns which lead to boundary violations in
      correctional and forensic settings, the differences in occupational roles should 
      be considered when examining ethics-based responsibilities.
FAU - Zwirn, Ilene
AU  - Zwirn I
AD  - Department of Psychiatry, Columbia University College of Physicians and Surgeons,
      New York, NY, USA. izwirnmd@aol.com
FAU - Owens, Howard
AU  - Owens H
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - J Am Acad Psychiatry Law
JT  - The journal of the American Academy of Psychiatry and the Law
JID - 9708963
SB  - IM
CON - J Am Acad Psychiatry Law. 2011;39(2):154-63. PMID: 21653256
MH  - Female
MH  - Forensic Psychiatry/*ethics
MH  - Humans
MH  - *Prisoners
MH  - *Professional Misconduct
MH  - Professional-Patient Relations/*ethics
MH  - *Sexual Behavior
EDAT- 2011/06/10 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/06/10 06:00
PHST- 2011/06/10 06:00 [entrez]
PHST- 2011/06/10 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
AID - 39/2/164 [pii]
PST - ppublish
SO  - J Am Acad Psychiatry Law. 2011;39(2):164-5.


PMID- 21652616
OWN - NLM
STAT- MEDLINE
DCOM- 20110907
LR  - 20220330
IS  - 1471-6771 (Electronic)
IS  - 0007-0912 (Linking)
VI  - 107
IP  - 2
DP  - 2011 Aug
TI  - Randomized trial comparing the i-gel and Magill tracheal tube with the single-use
      ILMA and ILMA tracheal tube for fibreoptic-guided intubation in anaesthetized
      patients with a predicted difficult airway.
PG  - 251-7
LID - 10.1093/bja/aer103 [doi]
AB  - BACKGROUND: The i-gel is a single-use supraglottic airway device (SAD) that
      allows fibreoptic-guided tracheal intubation through the device. Until now, no
      prospective data for this procedure are available. Therefore, in a prospective
      randomized controlled trial, we evaluated fibreoptic-guided tracheal intubation
      with a standard Rusch PVC tracheal tube (TT) through the i-gel compared with the 
      single-use ILMA (sILMA) TT through the sILMA in patients with a predicted
      difficult airway. METHODS: With ethics committee approval and written informed
      consent, 160 patients were randomly assigned to either SAD. After placement of
      the SAD, a fibreoptic bronchoscope was introduced into the trachea as a railroad 
      for the TT. Primary outcome variable was the first-attempt fibreoptic-guided
      intubation success rate. Secondary variables included time for insertion and
      intubation, airway leak pressures, fibreoptic view, and adverse events. Data are 
      presented as mean (sd) or percentages. A P-value of < 0.05 was considered
      statistically significant. RESULTS: Fibreoptic-guided intubation was successful
      at the first attempt in 76 patients (96%) using the i-gel and in 71 patients
      (90%) using the sILMA (P=0.21). Most of the failed intubations were rescued by
      conventional laryngoscopy. Airway leak pressure was higher for the sILMA. There
      were no problems during removal of either type of SAD. CONCLUSIONS:
      Fibreopic-guided tracheal intubation through the i-gel using a standard Rusch
      Magill TT is successful and an alternative to the sILMA with the sILMA TT.
FAU - Kleine-Brueggeney, M
AU  - Kleine-Brueggeney M
AD  - Department of Anesthesiology and Pain Therapy, Inselspital, University Hospital
      Bern, and University of Bern, Switzerland.
FAU - Theiler, L
AU  - Theiler L
FAU - Urwyler, N
AU  - Urwyler N
FAU - Vogt, A
AU  - Vogt A
FAU - Greif, R
AU  - Greif R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110607
PL  - England
TA  - Br J Anaesth
JT  - British journal of anaesthesia
JID - 0372541
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anesthesia, General/methods
MH  - Device Removal
MH  - Disposable Equipment
MH  - Equipment Design
MH  - Female
MH  - Fiber Optic Technology/*methods
MH  - Humans
MH  - Intubation, Intratracheal/adverse effects/*instrumentation
MH  - Laryngeal Masks/adverse effects
MH  - Male
MH  - Middle Aged
MH  - Pharyngitis/etiology
MH  - Postoperative Complications
MH  - Prospective Studies
MH  - Single-Blind Method
MH  - Young Adult
EDAT- 2011/06/10 06:00
MHDA- 2011/09/08 06:00
CRDT- 2011/06/10 06:00
PHST- 2011/06/10 06:00 [entrez]
PHST- 2011/06/10 06:00 [pubmed]
PHST- 2011/09/08 06:00 [medline]
AID - S0007-0912(17)33123-9 [pii]
AID - 10.1093/bja/aer103 [doi]
PST - ppublish
SO  - Br J Anaesth. 2011 Aug;107(2):251-7. doi: 10.1093/bja/aer103. Epub 2011 Jun 7.


PMID- 21652615
OWN - NLM
STAT- MEDLINE
DCOM- 20110907
LR  - 20220408
IS  - 1471-6771 (Electronic)
IS  - 0007-0912 (Linking)
VI  - 107
IP  - 2
DP  - 2011 Aug
TI  - Randomized clinical trial of the i-gel and Magill tracheal tube or single-use
      ILMA and ILMA tracheal tube for blind intubation in anaesthetized patients with a
      predicted difficult airway.
PG  - 243-50
LID - 10.1093/bja/aer102 [doi]
AB  - BACKGROUND: The single-use supraglottic airway device i-gel has been described in
      several case reports as a conduit for intubation, but no prospective data about
      success rates of blind intubation are available. Therefore, we performed this
      prospective randomized controlled trial to compare the success rate of blind
      tracheal intubation with a Magill PVC tube through the i-gel with intubation
      using an sILMA PVC tube through the single-use intubating laryngeal mask airway
      (sILMA). METHODS: With ethics committee approval and written informed consent, 80
      patients with predictors of a difficult airway were computer randomized to either
      supraglottic airway device (SAD). The corresponding tracheal tube (TT) was
      introduced through the SAD under fibreoptic visualization but without fibreoptic 
      guidance. Primary outcome was blind intubation success rate. Times, airway leak
      pressure, fibreoptic view, and adverse events were recorded. To control for the
      influence of the TT, we compared data from 40 patients described in an
      accompanying study (sILMA with Magill TT and i-gel with sILMA TT). RESULTS: Blind
      intubation success rate through the sILMA (69%) was higher than with the i-gel
      (15%, P<0.001). Data from the other patient group excluded the TT type as the
      primary cause for the difference in success rate. Removal of SADs was without
      problems with no difference between the type of SAD. CONCLUSIONS: Blind tracheal 
      intubation using the sILMA tube through the sILMA is much more successful than
      blind intubation with a Magill PVC tube through the i-gel. Because of its low
      success rate, we would not recommend blind intubation through the i-gel.
FAU - Theiler, L
AU  - Theiler L
AD  - Department of Anesthesiology and Pain Therapy, Inselspital, University Hospital
      Bern, and University of Bern, Switzerland.
FAU - Kleine-Brueggeney, M
AU  - Kleine-Brueggeney M
FAU - Urwyler, N
AU  - Urwyler N
FAU - Graf, T
AU  - Graf T
FAU - Luyet, C
AU  - Luyet C
FAU - Greif, R
AU  - Greif R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110607
PL  - England
TA  - Br J Anaesth
JT  - British journal of anaesthesia
JID - 0372541
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anesthesia, General/methods
MH  - Device Removal
MH  - Disposable Equipment
MH  - Equipment Design
MH  - Female
MH  - Fiber Optic Technology/methods
MH  - Hemodynamics
MH  - Humans
MH  - Intubation, Intratracheal/adverse effects/*instrumentation
MH  - Laryngeal Masks/adverse effects
MH  - Male
MH  - Middle Aged
MH  - Pharyngitis/etiology
MH  - Postoperative Complications
MH  - Prospective Studies
MH  - Young Adult
EDAT- 2011/06/10 06:00
MHDA- 2011/09/08 06:00
CRDT- 2011/06/10 06:00
PHST- 2011/06/10 06:00 [entrez]
PHST- 2011/06/10 06:00 [pubmed]
PHST- 2011/09/08 06:00 [medline]
AID - S0007-0912(17)33122-7 [pii]
AID - 10.1093/bja/aer102 [doi]
PST - ppublish
SO  - Br J Anaesth. 2011 Aug;107(2):243-50. doi: 10.1093/bja/aer102. Epub 2011 Jun 7.


PMID- 21652518
OWN - NLM
STAT- MEDLINE
DCOM- 20120417
LR  - 20141120
IS  - 1470-2738 (Electronic)
IS  - 0143-005X (Linking)
VI  - 66
IP  - 1
DP  - 2012 Jan
TI  - Damned if you do, damned if you don't: subgroup analysis and equity.
PG  - 95-8
LID - 10.1136/jech.2010.121095 [doi]
AB  - The final report from the WHO Commission on the social determinants of health
      recently noted: 'For policy, however important an ethical imperative, values
      alone are insufficient. There needs to be evidence on what can be done and what
      is likely to work in practice to improve health and reduce health inequities.'
      This is challenging, because understanding how to reduce health inequities
      between the poorest and better-off members of society may require a greater use
      of subgroup analysis to explore the differential effects of public health
      interventions. However, while this may produce evidence that is more policy
      relevant, the requisite subgroup analyses are often seen as tantamount to
      statistical malpractice. This paper considers some of the methodological problems
      with subgroup analysis, and its applicability to considerations of equity, using 
      both clinical and public health examples. Finally, it suggests how policy needs
      for information on subgroups can be met while maintaining rigour.
FAU - Petticrew, Mark
AU  - Petticrew M
AD  - Department of Social and Environmental Health Research, Faculty of Public Health 
      and Policy, London School of Hygiene and Tropical Medicine, 15-17 Tavistock
      Place, London WC1H 9SH, UK. mark.petticrew@lshtm.ac.uk
FAU - Tugwell, Peter
AU  - Tugwell P
FAU - Kristjansson, Elizabeth
AU  - Kristjansson E
FAU - Oliver, Sandy
AU  - Oliver S
FAU - Ueffing, Erin
AU  - Ueffing E
FAU - Welch, Vivian
AU  - Welch V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110606
PL  - England
TA  - J Epidemiol Community Health
JT  - Journal of epidemiology and community health
JID - 7909766
SB  - IM
MH  - *Data Interpretation, Statistical
MH  - *Epidemiologic Factors
MH  - Global Health
MH  - *Health Status Disparities
MH  - Humans
MH  - Public Health/*statistics & numerical data
MH  - United States
MH  - *World Health Organization
EDAT- 2011/06/10 06:00
MHDA- 2012/04/18 06:00
CRDT- 2011/06/10 06:00
PHST- 2011/06/10 06:00 [entrez]
PHST- 2011/06/10 06:00 [pubmed]
PHST- 2012/04/18 06:00 [medline]
AID - jech.2010.121095 [pii]
AID - 10.1136/jech.2010.121095 [doi]
PST - ppublish
SO  - J Epidemiol Community Health. 2012 Jan;66(1):95-8. doi: 10.1136/jech.2010.121095.
      Epub 2011 Jun 6.


PMID- 21651993
OWN - NLM
STAT- MEDLINE
DCOM- 20120201
LR  - 20110909
IS  - 1559-2030 (Electronic)
IS  - 1551-7144 (Linking)
VI  - 32 Suppl 1
DP  - 2011 Sep
TI  - Continuous safety monitoring for randomized controlled clinical trials with
      blinded treatment information. Part 4: One method.
PG  - S11-7
LID - 10.1016/j.cct.2011.05.008 [doi]
AB  - Standard methods for testing safety data are needed to ensure the safe conduct of
      clinical trials. In particular, objective rules for reliably identifying unsafe
      treatments need to be put into place to help protect patients from unnecessary
      harm. DMCs are uniquely qualified to evaluate accumulating unblinded data and
      make recommendations about the continuing safe conduct of a trial. However, it is
      the trial leadership who must make the tough ethical decision about stopping a
      trial, and they could benefit from objective statistical rules that help them
      judge the strength of evidence contained in the blinded data. We design objective
      early stopping rules for harm that act as continuous safety screens for
      randomized controlled clinical trials using the accumulating data with blinded
      treatment information, which could be used by anyone, including trial
      investigators and trial leadership. A Bayesian framework, with emphasis on the
      likelihood function, is used to allow for continuous monitoring without adjusting
      for multiple comparisons. Close collaboration between the statistician and the
      clinical investigators will be needed in order to design safety screens with good
      operating characteristics. Though the math underlying this procedure may be
      computationally intensive, implementation of the statistical rules will be easy
      and the continuous screening provided will give suitabley early warning when real
      problems were to emerge. Trial investigators and trial leadership need these
      safety screens to help them to effectively monitor the ongoing safe conduct of
      clinical trials with blinded data.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Ball, Greg
AU  - Ball G
AD  - Astellas Pharma Global Development, 3 Parkway N, Deerfield, IL 60015, USA.
      greg.ball@us.astellas.com
LA  - eng
PT  - Journal Article
DEP - 20110601
PL  - United States
TA  - Contemp Clin Trials
JT  - Contemporary clinical trials
JID - 101242342
SB  - IM
MH  - Bayes Theorem
MH  - Decision Making
MH  - Double-Blind Method
MH  - Humans
MH  - Patient Safety/*standards
MH  - *Randomized Controlled Trials as Topic/methods/standards
MH  - Research Personnel/psychology
MH  - Risk Assessment
EDAT- 2011/06/10 06:00
MHDA- 2012/02/02 06:00
CRDT- 2011/06/10 06:00
PHST- 2010/12/09 00:00 [received]
PHST- 2011/05/01 00:00 [revised]
PHST- 2011/05/21 00:00 [accepted]
PHST- 2011/06/10 06:00 [entrez]
PHST- 2011/06/10 06:00 [pubmed]
PHST- 2012/02/02 06:00 [medline]
AID - S1551-7144(11)00134-0 [pii]
AID - 10.1016/j.cct.2011.05.008 [doi]
PST - ppublish
SO  - Contemp Clin Trials. 2011 Sep;32 Suppl 1:S11-7. doi: 10.1016/j.cct.2011.05.008.
      Epub 2011 Jun 1.


PMID- 21650142
OWN - NLM
STAT- MEDLINE
DCOM- 20110712
LR  - 20161018
IS  - 1060-5487 (Print)
IS  - 1060-5487 (Linking)
VI  - 82
IP  - 4
DP  - 2011 Apr
TI  - Everyday ethics. AHIMA code of ethics guides daily work, complex situations.
PG  - 30-3
FAU - Crawford, Mark
AU  - Crawford M
AD  - mark.crawford@charter.net
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J AHIMA
JT  - Journal of AHIMA
JID - 9202024
MH  - *Codes of Ethics
MH  - Hospital Information Systems
MH  - Humans
MH  - Information Management/*ethics
MH  - *Societies
EDAT- 2011/06/10 06:00
MHDA- 2011/07/13 06:00
CRDT- 2011/06/10 06:00
PHST- 2011/06/10 06:00 [entrez]
PHST- 2011/06/10 06:00 [pubmed]
PHST- 2011/07/13 06:00 [medline]
PST - ppublish
SO  - J AHIMA. 2011 Apr;82(4):30-3.


PMID- 21649944
OWN - NLM
STAT- MEDLINE
DCOM- 20111005
LR  - 20110608
IS  - 1876-8784 (Electronic)
IS  - 0028-2162 (Linking)
VI  - 155
DP  - 2011
TI  - [Interdisciplinary cooperation in occupational health: ethical friction].
PG  - A2303
AB  - OBJECTIVE: To investigate which ethical considerations play a role in the
      assessment of absenteeism due to sickness and of disability, and how these are
      dealt with. DESIGN: Qualitative, exploratory study. METHOD: We conducted
      interviews with 32 individual professional practitioners: 8 occupational health
      physicians, 8 insurance company physicians, 8 general practitioners, and 8
      psychologists, with the aid of a semi-structured questionnaire. During the
      interview we differentiated between 4 clusters of questions referring to the
      ethical, legal, interdisciplinary, and professional context, respectively. The
      study revealed only the spectrum of ethical considerations that played a role,
      and not the representativeness. For this reason the results did not allow for
      quantitative conclusions. RESULTS: Differences in the manner of thinking and
      behaving between health-care providers stem from differences in ethical
      considerations and in background beliefs. These differences hinder effective
      cooperation within the occupational health sector. CONCLUSION: To improve
      professional performance and to achieve more responsible decision-making those
      involved need to be aware of their ethical considerations and background beliefs 
      and to make them explicit, possibly with the aid of a checklist.
FAU - den Besten, Inge E
AU  - den Besten IE
AD  - Erasmus MC, afd. Medische Ethiek en Filosofie, Rotterdam, the Netherlands.
FAU - Nauta, A P Noks
AU  - Nauta AP
FAU - Faas, W A Jim
AU  - Faas WA
FAU - Weel, Andre N H
AU  - Weel AN
FAU - Zwart, Kerst
AU  - Zwart K
FAU - Hilhorst, M T Medard
AU  - Hilhorst MT
LA  - dut
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
TT  - Interdisciplinair werken bij arbeid en gezondheid: ethische fricties.
PL  - Netherlands
TA  - Ned Tijdschr Geneeskd
JT  - Nederlands tijdschrift voor geneeskunde
JID - 0400770
SB  - IM
MH  - *Absenteeism
MH  - *Decision Making
MH  - Disability Evaluation
MH  - Humans
MH  - Netherlands
MH  - Occupational Health/legislation & jurisprudence/*statistics & numerical data
MH  - Patient Care Team/*ethics/standards
MH  - Professional Role
MH  - *Sick Leave
MH  - Social Responsibility
EDAT- 2011/06/09 06:00
MHDA- 2011/10/06 06:00
CRDT- 2011/06/09 06:00
PHST- 2011/06/09 06:00 [entrez]
PHST- 2011/06/09 06:00 [pubmed]
PHST- 2011/10/06 06:00 [medline]
PST - ppublish
SO  - Ned Tijdschr Geneeskd. 2011;155:A2303.


PMID- 21649704
OWN - NLM
STAT- MEDLINE
DCOM- 20110915
LR  - 20211020
IS  - 1365-2923 (Electronic)
IS  - 0308-0110 (Linking)
VI  - 45
IP  - 7
DP  - 2011 Jul
TI  - Everyday ethics in internal medicine resident clinic: an opportunity to teach.
PG  - 712-21
LID - 10.1111/j.1365-2923.2011.03931.x [doi]
AB  - OBJECTIVES: Being a good doctor requires competency in ethics. Accordingly,
      ethics education during residency training is important. We studied the everyday 
      ethics-related issues (i.e. ordinary ethics issues commonly faced) that internal 
      medical residents encounter in their out-patient clinic and determined whether
      teaching about these issues occurred during faculty preceptor-resident
      interactions. METHODS: This study involved a multi-method qualitative research
      design combining observation of preceptor-resident discussions with preceptor
      interviews. The study was conducted in two different internal medicine training
      programme clinics over a 2-week period in June 2007. Fifty-three residents and 19
      preceptors were observed, and 10 preceptors were interviewed. Transcripts of
      observer field notes and faculty interviews were carefully analysed. The analysis
      identified several themes of everyday ethics issues and determined whether
      preceptors identified and taught about these issues. RESULTS: Everyday ethics
      content was considered present in 109 (81%) of the 135 observed case
      presentations. Three major thematic domains and associated sub-themes related to 
      everyday ethics issues were identified, concerning: (i) the Doctor-Patient
      Interaction (relationships; communication; shared decision making); (ii) the
      Resident as Learner (developmental issues; challenges and conflicts associated
      with training; relationships with colleagues and mentors; interactions with the
      preceptor), and; (iii) the Doctor-System Interaction (financial issues;
      doctor-system issues; external influences; doctor frustration related to system
      issues). Everyday ethics issues were explicitly identified by preceptors (without
      teaching) in 18 of 109 cases (17%); explicit identification and teaching occurred
      in only 13 cases (12%). CONCLUSIONS: In this study a variety of everyday ethics
      issues were frequently encountered as residents cared for patients. Yet, faculty 
      preceptors infrequently explicitly identified or taught these issues during their
      interactions with residents. Ethics education is important and residents may
      regard teaching about the ethics-related issues they actually encounter to be
      highly relevant. A better understanding of the barriers to teaching is needed in 
      order to promote education about everyday ethics in the out-patient setting.
CI  - (c) Blackwell Publishing Ltd 2011.
FAU - Carrese, Joseph A
AU  - Carrese JA
AD  - Johns Hopkins Berman Institute of Bioethics, Johns Hopkins University, Baltimore,
      Maryland, USA. jcarrese@jhmi.edu
FAU - McDonald, Erin L
AU  - McDonald EL
FAU - Moon, Margaret
AU  - Moon M
FAU - Taylor, Holly A
AU  - Taylor HA
FAU - Khaira, Kiran
AU  - Khaira K
FAU - Catherine Beach, Mary
AU  - Catherine Beach M
FAU - Hughes, Mark T
AU  - Hughes MT
LA  - eng
GR  - L60 MD000303/MD/NIMHD NIH HHS/United States
GR  - L60 MD000303-01/MD/NIMHD NIH HHS/United States
GR  - L60 MD000303-02/MD/NIMHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Med Educ
JT  - Medical education
JID - 7605655
SB  - IM
CIN - Med Educ. 2011 Jul;45(7):658-60. PMID: 21649696
MH  - Ethics, Medical/*education
MH  - Humans
MH  - Internal Medicine/*education/ethics
MH  - Internship and Residency/*methods
MH  - Outpatient Clinics, Hospital/ethics
MH  - Physician-Patient Relations/ethics
MH  - Preceptorship/methods
PMC - PMC3233355
MID - NIHMS340965
EDAT- 2011/06/09 06:00
MHDA- 2011/09/16 06:00
CRDT- 2011/06/09 06:00
PHST- 2011/06/09 06:00 [entrez]
PHST- 2011/06/09 06:00 [pubmed]
PHST- 2011/09/16 06:00 [medline]
AID - 10.1111/j.1365-2923.2011.03931.x [doi]
PST - ppublish
SO  - Med Educ. 2011 Jul;45(7):712-21. doi: 10.1111/j.1365-2923.2011.03931.x.


PMID- 21649703
OWN - NLM
STAT- MEDLINE
DCOM- 20110915
LR  - 20220318
IS  - 1365-2923 (Electronic)
IS  - 0308-0110 (Linking)
VI  - 45
IP  - 7
DP  - 2011 Jul
TI  - Ethical issues encountered by medical students during international health
      electives.
PG  - 704-11
LID - 10.1111/j.1365-2923.2011.03936.x [doi]
AB  - CONTEXT: Medical students increasingly wish to participate in international
      health electives (IHEs). The authors undertook to understand from the students'
      perspective the ethical challenges encountered on IHEs in low-resource settings
      and how students respond to these issues. METHODS: Semi-structured interviews
      were conducted with 12 medical students upon their return from an IHE. A
      purposive sampling strategy was used. Inductive data analysis using a constant
      comparative technique generated initial codes which were later organised into
      higher-order themes. RESULTS: Five themes relating to ethical issues were
      identified: (i) uncertainty about how best to help; (ii) perceptions of Western
      medical students as different; (iii) moving beyond one's scope of practice; (iv) 
      navigating different cultures of medicine, and (v) unilateral capacity building. 
      CONCLUSIONS: International health electives are associated with a range of
      ethical issues for students. Students would benefit from formal pre-departure
      training, which should include an evaluation of their expectations of and
      motivations for participating in an IHE, careful selection of the IHE from
      amongst the opportunities available, learning about the local context of the IHE 
      prior to departure, and the exploration and discussion of ethical and
      professionalism issues. Other factors that would benefit students include having 
      an invested onsite colleague or supervisor, maintaining an ongoing connection
      with the home institution, and formal debriefing on conclusion of the IHE.
CI  - (c) Blackwell Publishing Ltd 2011.
FAU - Elit, Laurie
AU  - Elit L
AD  - Department of Obstetrics and Gynaecology, McMaster University, Hamilton, Ontario,
      Canada. laurie.elit@jcc.hhsc.ca
FAU - Hunt, Matthew
AU  - Hunt M
FAU - Redwood-Campbell, Lynda
AU  - Redwood-Campbell L
FAU - Ranford, Jennifer
AU  - Ranford J
FAU - Adelson, Naomi
AU  - Adelson N
FAU - Schwartz, Lisa
AU  - Schwartz L
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Med Educ
JT  - Medical education
JID - 7605655
SB  - IM
CIN - Med Educ. 2011 Jul;45(7):658-60. PMID: 21649696
MH  - Adult
MH  - Attitude of Health Personnel
MH  - Bioethical Issues
MH  - Developing Countries
MH  - Education, Medical, Undergraduate/*ethics/methods
MH  - *Ethics, Medical
MH  - Female
MH  - Humans
MH  - *International Educational Exchange
MH  - Male
MH  - *Medically Underserved Area
MH  - Students, Medical/*psychology
MH  - Uncertainty
MH  - Young Adult
EDAT- 2011/06/09 06:00
MHDA- 2011/09/16 06:00
CRDT- 2011/06/09 06:00
PHST- 2011/06/09 06:00 [entrez]
PHST- 2011/06/09 06:00 [pubmed]
PHST- 2011/09/16 06:00 [medline]
AID - 10.1111/j.1365-2923.2011.03936.x [doi]
PST - ppublish
SO  - Med Educ. 2011 Jul;45(7):704-11. doi: 10.1111/j.1365-2923.2011.03936.x.


PMID- 21649696
OWN - NLM
STAT- MEDLINE
DCOM- 20110915
LR  - 20110608
IS  - 1365-2923 (Electronic)
IS  - 0308-0110 (Linking)
VI  - 45
IP  - 7
DP  - 2011 Jul
TI  - Ethics lie in the situation and in the response.
PG  - 658-60
LID - 10.1111/j.1365-2923.2011.04028.x [doi]
FAU - Caldicott, Catherine
AU  - Caldicott C
AD  - Center for Personalized Education for Physicians, 7351 Lowry Boulevard, Suite
      100, Denver, Colorado 880230, USA. cvcaldicott@yahoo.com
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - England
TA  - Med Educ
JT  - Medical education
JID - 7605655
SB  - IM
CON - Med Educ. 2011 Jul;45(7):704-11. PMID: 21649703
CON - Med Educ. 2011 Jul;45(7):712-21. PMID: 21649704
MH  - Attitude of Health Personnel
MH  - Education, Medical/*methods
MH  - Ethics, Medical/*education
MH  - Humans
MH  - International Educational Exchange
MH  - Outpatient Clinics, Hospital/ethics
MH  - Physician-Patient Relations/ethics
MH  - Students, Medical/psychology
EDAT- 2011/06/09 06:00
MHDA- 2011/09/16 06:00
CRDT- 2011/06/09 06:00
PHST- 2011/06/09 06:00 [entrez]
PHST- 2011/06/09 06:00 [pubmed]
PHST- 2011/09/16 06:00 [medline]
AID - 10.1111/j.1365-2923.2011.04028.x [doi]
PST - ppublish
SO  - Med Educ. 2011 Jul;45(7):658-60. doi: 10.1111/j.1365-2923.2011.04028.x.


PMID- 21649686
OWN - NLM
STAT- MEDLINE
DCOM- 20120719
LR  - 20141113
IS  - 1471-6712 (Electronic)
IS  - 0283-9318 (Linking)
VI  - 26
IP  - 1
DP  - 2012 Mar
TI  - Lateral epicondylalgia. A quantitative and qualitative analysis of
      interdisciplinary cooperation and treatment choice in the Swedish health care
      system.
PG  - 28-37
LID - 10.1111/j.1471-6712.2011.00899.x [doi]
AB  - OBJECTIVE AND AIM: Interdisciplinary cooperation is essential to develop a broad 
      range of knowledge and skills. The aim of this study was to describe health care 
      professionals' treatment choices, their cooperation with other professionals and 
      their perceptions of potential risks regarding treatments of acute lateral
      epicondylalgia (LE). DESIGN: A quantitative descriptive study design with a
      summative approach to qualitative analysis. ETHICAL ISSUES: The ethical committee
      was asked verbally for approval but, as this study was performed to develop an
      organised way to treat LE, it did not require approval. The four ethical aspects 
      information, consent, confidentiality and the use of the study materials were all
      addressed. SUBJECTS: All orthopaedic surgeons, general practitioners,
      physiotherapists and occupational therapists in a county. METHODS: Questionnaire 
      with 18 dichotomous, multiple-response, multiple-choice questions and three
      open-ended questions were analysed using quantitative cross-tab and qualitative
      content analysis with summative approach. RESULTS: The most common treatment
      choices were Non Steroidal Anti Inflammatory Drugs (NSAID), corticosteroid
      injections, training programmes, braces and ergonomics. Advantages from
      interdisciplinary cooperation were higher rated than disadvantages. The
      qualitative findings dealt with perceptions of interdisciplinary cooperation and 
      resulted in three categories; right level of care, increased quality of care and 
      decreased quality of care. Almost half of the physicians felt potential risks
      associated with their treatment methods. The qualitative findings dealt with
      perceptions of the potential risks and resulted in two categories: side effects
      and inadequate treatment. STUDY LIMITATIONS: The number of responses varied
      because some of the respondents did not answered all of the questions.
      CONCLUSION: Interdisciplinary cooperation in the treatment of patients with acute
      LE benefits the patients by shortening the rehabilitation period and provides
      health care professionals the opportunity for an improved learning and exchanging
      experiences. These basic conditions must be met to improve health care quality.
CI  - (c) 2011 The Authors. Scandinavian Journal of Caring Sciences (c) 2011 Nordic
      College of Caring Science.
FAU - Nilsson, Pia
AU  - Nilsson P
AD  - Research and Development Unit, Primary Health Care, General Practice and Public
      Health, Falkenberg, Sweden. pia.nilsson@lthalland.se
FAU - Lindgren, Eva-Carin
AU  - Lindgren EC
FAU - Mansson, Jorgen
AU  - Mansson J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110608
PL  - Sweden
TA  - Scand J Caring Sci
JT  - Scandinavian journal of caring sciences
JID - 8804206
MH  - *Attitude of Health Personnel
MH  - *Decision Making
MH  - Female
MH  - General Practice
MH  - Health Care Surveys
MH  - Humans
MH  - *Interprofessional Relations
MH  - Male
MH  - Occupational Therapy
MH  - Orthopedics
MH  - *Patient Care Management
MH  - Physical Therapy Modalities
MH  - Sweden
MH  - Tennis Elbow/rehabilitation/*therapy
EDAT- 2011/06/09 06:00
MHDA- 2012/07/20 06:00
CRDT- 2011/06/09 06:00
PHST- 2011/06/09 06:00 [entrez]
PHST- 2011/06/09 06:00 [pubmed]
PHST- 2012/07/20 06:00 [medline]
AID - 10.1111/j.1471-6712.2011.00899.x [doi]
PST - ppublish
SO  - Scand J Caring Sci. 2012 Mar;26(1):28-37. doi: 10.1111/j.1471-6712.2011.00899.x. 
      Epub 2011 Jun 8.


PMID- 21649685
OWN - NLM
STAT- MEDLINE
DCOM- 20130529
LR  - 20211020
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 26
IP  - 9
DP  - 2012 Nov
TI  - 'They say Islam has a solution for everything, so why are there no guidelines for
      this?' Ethical dilemmas associated with the births and deaths of infants with
      fatal abnormalities from a small sample of Pakistani Muslim couples in Britain.
PG  - 485-92
LID - 10.1111/j.1467-8519.2011.01883.x [doi]
AB  - This paper presents ethical dilemmas concerning the termination of pregnancy, the
      management of childbirth, and the withdrawal of life-support from infants in
      special care, for a small sample of British Pakistani Muslim parents of babies
      diagnosed with fatal abnormalities. Case studies illustrating these dilemmas are 
      taken from a qualitative study of 66 families of Pakistani origin referred to a
      genetics clinic in Southern England. The paper shows how parents negotiated
      between the authoritative knowledge of their doctors, religious experts, and
      senior family members in response to the ethical dilemmas they faced. There was
      little knowledge or open discussion of the view that Islam permits the
      termination of pregnancy for serious or fatal abnormality within 120 days and
      there was considerable disquiet over the idea of ending a pregnancy. For some
      parents, whether their newborn baby would draw breath was a main worry, with
      implications for the baby's Muslim identity and for the recognition of loss the
      parents would receive from family and community. This concern sometimes
      conflicted with doctors' concerns to minimize risk to future pregnancies by not
      performing a Caesarean delivery if a baby is sure to die. The paper also
      identifies parents' concerns and feelings of wrong-doing regarding the withdrawal
      of artificial life-support from infants with multiple abnormalities. The
      conclusion considers some of the implications of these observations for the
      counselling and support of Muslim parents following the pre- or neo-natal
      diagnosis of fatal abnormalities in their children.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Shaw, Alison
AU  - Shaw A
AD  - Department of Public Health, University of Oxford. Alison.Shaw@dphpc.ox.ac.uk
LA  - eng
GR  - GR063078MA/Wellcome Trust/United Kingdom
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110607
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - *Abnormalities, Multiple
MH  - Abortion, Induced/*ethics
MH  - Delivery, Obstetric/ethics
MH  - England
MH  - Female
MH  - Humans
MH  - *Islam
MH  - Pakistan/ethnology
MH  - Pregnancy
MH  - Prenatal Diagnosis/ethics
MH  - *Religion and Medicine
MH  - Withholding Treatment/*ethics
PMC - PMC3500506
EDAT- 2011/06/09 06:00
MHDA- 2013/05/31 06:00
CRDT- 2011/06/09 06:00
PHST- 2011/06/09 06:00 [entrez]
PHST- 2011/06/09 06:00 [pubmed]
PHST- 2013/05/31 06:00 [medline]
AID - 10.1111/j.1467-8519.2011.01883.x [doi]
PST - ppublish
SO  - Bioethics. 2012 Nov;26(9):485-92. doi: 10.1111/j.1467-8519.2011.01883.x. Epub
      2011 Jun 7.


PMID- 21649566
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20120217
IS  - 2146-8427 (Electronic)
IS  - 1304-0855 (Linking)
VI  - 9
IP  - 3
DP  - 2011 Jun
TI  - Expanding the live kidney donor pool: ethical considerations regarding altruistic
      donors, paired and pooled programs.
PG  - 181-6
AB  - In renal transplant, there is a well-known deficiency in organ supply relative to
      demand. Live donation provides superior results when compared with deceased
      donation including a better rate of graft success and fewer immunologic
      complications. This deficiency in organs leads to significant morbidity and
      mortality rates. Alternative avenues have been extensively explored that may
      expand the live donor pool. They include altruistic donation as well as paired
      and pooled exchange programs. Altruistic donation is a truly selfless act from a 
      donor unknown to the recipient. Kidney paired donation involves 2 incompatible
      donor-recipient pairs swapping donors to produce compatibility. Pooled donation
      involves at least 2 pairs, and can take the form of domino chains in which
      altruistic input sets up a chain of transplants, in which each recipient's
      incompatible donor makes a donation for the next recipient. Despite application
      of these various methods, there lie extensive ethical issues surrounding them.
      Misconceptions frequently occur; for instance, the perceived benefit that
      donating an organ to a loved one is greater for a related donor than for an
      altruistic one. Additionally, it is frequently believed that immunologic
      incompatibility offers coerced donors liberation from surgery, and that
      overcoming these barriers by introducing exchange programs provides vulnerable
      donors less protection. This article explores these and other complex ethical
      issues surrounding the various methods of expanding the donor pool. The authors
      offer opinions that challenge the ethical issues and attempt to overcome those
      views that hinder progress in the field.
FAU - Patel, Shaneel Rajendra
AU  - Patel SR
AD  - The West London Renal and Transplant Centre, Imperial College Kidney and
      Transplant Institute, Imperial College Healthcare NHS Trust, Hammersmith
      Hospital, London, United Kingdom. Shaneel.patel06@imperial.ac.uk
FAU - Chadha, Priyanka
AU  - Chadha P
FAU - Papalois, Vassilios
AU  - Papalois V
LA  - eng
PT  - Journal Article
PL  - Turkey
TA  - Exp Clin Transplant
JT  - Experimental and clinical transplantation : official journal of the Middle East
      Society for Organ Transplantation
JID - 101207333
SB  - IM
MH  - *Altruism
MH  - Directed Tissue Donation/ethics
MH  - Donor Selection/ethics
MH  - Gift Giving/*ethics
MH  - Humans
MH  - Kidney Transplantation/*ethics
MH  - Living Donors/ethics/psychology/*supply & distribution
MH  - Motivation
MH  - Patient Rights
MH  - Program Development
MH  - Tissue and Organ Procurement/*ethics
EDAT- 2011/06/09 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/06/09 06:00
PHST- 2011/06/09 06:00 [entrez]
PHST- 2011/06/09 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
PST - ppublish
SO  - Exp Clin Transplant. 2011 Jun;9(3):181-6.


PMID- 21648323
OWN - NLM
STAT- MEDLINE
DCOM- 20110802
LR  - 20151119
IS  - 0350-6134 (Print)
IS  - 0350-6134 (Linking)
VI  - 35 Suppl 1
DP  - 2011 Jan
TI  - Blood pressure dipping and salivary cortisol as markers of fatigue and sleep
      deprivation in staff anesthesiologists.
PG  - 133-8
AB  - Anesthesiologists often work extended duty shifts that result in acute and
      chronic sleep loss and circadian disruption. Stress caused by sleep deprivation, 
      together with excessive workload could contribute to acute increases in blood
      pressure (BP) and sympathetic nervous system activity. Non-dipping pattern of BP 
      is considered an additional risk factor for cardiovascular events and target
      organ damage. We hypothesized that there would be significant changes of
      cardiovascular parameters when comparing work on call during the 24-hour
      in-hospital shift (24-HD) versus ordinary working day (8-HD) combined with
      changes of dipping pattern and altered diurnal cortisol secretion, measured by
      salivary cortisol (SC). Following local Medical Ethics Committee approval, 12 out
      of 36 staff anesthesiologists (8 male, 4 female), 33-61 years old, participated
      in this study. Ambulatory BP monitor was used for noninvasive 24-hour ambulatory 
      BP and heart rate (HR) monitoring. Each participant was monitored continuously
      during the 8-HD, as well as during the 24-HD. Saliva for analysis of cortisol
      levels was collected six times a day (at 8 am, 11 am, 2 pm, 5pm, 8pm, and 11 pm) 
      both during 8-HD and on 24-HD. There was a significant decrease in number of
      diastolic dippers on call vs. diastolic dippers on ordinary working day (4/12 vs.
      10/12, p=0.036), and non significant decrease of systolic dippers (3/12 vs. 7/12,
      p =0.214). There were no significant differences in SC values between 8-HD and
      24-HD at all observed time points. However, the SC values measured during the
      night were markedly elevated on both days compared with reference values and the 
      shapes of SC curves were altered. The lack of diastolic BP dipping could be more 
      sensitive indicator of stress among staff anesthesiologists than systolic BP
      dipping. The shape of SC diurnal curve in terms of elevated night values could be
      another indicator of their chronic fatigue.
FAU - Carev, Mladen
AU  - Carev M
AD  - University of Split, Split University Hospital Center, Department of
      Anesthesiology and Intensive Care, Split, Croatia.
FAU - Karanovic, Nenad
AU  - Karanovic N
FAU - Bagatin, Jugoslav
AU  - Bagatin J
FAU - Matulic, Nina Berovic
AU  - Matulic NB
FAU - Pecotic, Renata
AU  - Pecotic R
FAU - Valic, Maja
AU  - Valic M
FAU - Marinovic-Terzic, Ivana
AU  - Marinovic-Terzic I
FAU - Karanovic, Sandra
AU  - Karanovic S
FAU - Dogas, Zoran
AU  - Dogas Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Croatia
TA  - Coll Antropol
JT  - Collegium antropologicum
JID - 8003354
RN  - 0 (Biomarkers)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adult
MH  - *Anesthesiology
MH  - Biomarkers/analysis
MH  - Blood Pressure Monitoring, Ambulatory
MH  - Fatigue/*diagnosis/metabolism
MH  - Female
MH  - Humans
MH  - Hydrocortisone/*metabolism
MH  - Hypotension/*diagnosis/metabolism
MH  - Male
MH  - Middle Aged
MH  - *Physicians
MH  - Saliva/*metabolism
MH  - Sleep Deprivation/*diagnosis/metabolism
MH  - Work Schedule Tolerance
EDAT- 2011/06/09 06:00
MHDA- 2011/08/04 06:00
CRDT- 2011/06/09 06:00
PHST- 2011/06/09 06:00 [entrez]
PHST- 2011/06/09 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
PST - ppublish
SO  - Coll Antropol. 2011 Jan;35 Suppl 1:133-8.


PMID- 21647594
OWN - NLM
STAT- MEDLINE
DCOM- 20120209
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 17
IP  - 2
DP  - 2011 Jun
TI  - Authorship and publication practices in the social sciences: historical
      reflections on current practices.
PG  - 365-88
LID - 10.1007/s11948-011-9280-4 [doi]
AB  - An historical review of authorship definitions and publication practices that are
      embedded in directions to authors and in the codes of ethics in the fields of
      psychology, sociology, and education illuminates reasonable agreement and
      consistency across the fields with regard to (a) originality of the work
      submitted, (b) data sharing, (c) human participants' protection, and (d) conflict
      of interest disclosure. However, the role of the professional association in
      addressing violations of research or publication practices varies among these
      fields. Psychology and sociology provide active oversight with sanction
      authority. In education, the association assumes a more limited role: to develop 
      and communicate standards to evoke voluntary compliance. With respect to
      authorship credit, each association's standards focus on criteria for inclusion
      as an author, other than on the author's ability to defend and willingness to
      take responsibility for the entire work. Discussions across a broad range of
      research disciplines beyond the social sciences would likely be beneficial.
      Whether improved standards will reduce either misattribution or perceptions of
      inappropriate attribution of credit within social science disciplines will likely
      depend on how well authorship issues are addressed in responsible conduct of
      research education (RCR), in research practice, and in each association's ongoing
      efforts to influence normative practice by specifying and clarifying best
      practices.
FAU - Bebeau, Muriel J
AU  - Bebeau MJ
AD  - School of Dentistry, University of Minnesota, 15-136 Moos Tower, 515 Delaware
      S.E., Minneapolis, MN 55455, USA. bebea001@umn.edu
FAU - Monson, Verna
AU  - Monson V
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110607
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Authorship
MH  - *Bibliometrics
MH  - *Codes of Ethics
MH  - *Editorial Policies
MH  - *Ethics, Research
MH  - Peer Review, Research
MH  - Psychology/*ethics
MH  - Social Sciences/*ethics
EDAT- 2011/06/08 06:00
MHDA- 2012/02/10 06:00
CRDT- 2011/06/08 06:00
PHST- 2007/10/10 00:00 [received]
PHST- 2011/03/28 00:00 [accepted]
PHST- 2011/06/08 06:00 [entrez]
PHST- 2011/06/08 06:00 [pubmed]
PHST- 2012/02/10 06:00 [medline]
AID - 10.1007/s11948-011-9280-4 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2011 Jun;17(2):365-88. doi: 10.1007/s11948-011-9280-4. Epub 2011 
      Jun 7.


PMID- 21647328
OWN - NLM
STAT- MEDLINE
DCOM- 20111012
LR  - 20211020
IS  - 1449-1907 (Electronic)
IS  - 1449-1907 (Linking)
VI  - 8
IP  - 4
DP  - 2011
TI  - Medical decision and patient's preference: 'much ethics' and more trust always
      needed.
PG  - 351-2
AB  - There is much discussion on medical ethics literature regarding the importance of
      the patients' right for self-determination. We discuss some of the limitations of
      patient's autonomy with the aim to draw attention to the ethical complexity of
      medical decision making in the everyday clinical practice.
FAU - Anyfantakis, Dimitrios
AU  - Anyfantakis D
FAU - Symvoulakis, Emmanouil K
AU  - Symvoulakis EK
LA  - eng
PT  - Letter
DEP - 20110531
PL  - Australia
TA  - Int J Med Sci
JT  - International journal of medical sciences
JID - 101213954
SB  - IM
MH  - Critical Care/ethics
MH  - Decision Making/*ethics
MH  - Empathy/ethics
MH  - *Ethics, Medical
MH  - Humans
MH  - Informed Consent
MH  - Life Support Care/ethics
MH  - Mental Competency
MH  - Patient Participation/psychology
MH  - Patient Rights/*ethics
MH  - *Personal Autonomy
MH  - Physician-Patient Relations/ethics
MH  - Tissue and Organ Procurement
MH  - *Trust
PMC - PMC3107468
OTO - NOTNLM
OT  - autonomy
OT  - informed consent
OT  - medical decision making
EDAT- 2011/06/08 06:00
MHDA- 2011/10/13 06:00
CRDT- 2011/06/08 06:00
PHST- 2011/04/02 00:00 [received]
PHST- 2011/05/25 00:00 [accepted]
PHST- 2011/06/08 06:00 [entrez]
PHST- 2011/06/08 06:00 [pubmed]
PHST- 2011/10/13 06:00 [medline]
AID - 10.7150/ijms.8.351 [doi]
PST - ppublish
SO  - Int J Med Sci. 2011;8(4):351-2. doi: 10.7150/ijms.8.351. Epub 2011 May 31.


PMID- 21647075
OWN - NLM
STAT- MEDLINE
DCOM- 20110722
LR  - 20110607
IS  - 1357-6321 (Print)
IS  - 1357-6321 (Linking)
VI  - 17
IP  - 5
DP  - 2011 May
TI  - Principles of nutrition in the palliation of long-term conditions.
PG  - 217-22
AB  - Palliative care, directed toward alleviating symptoms and improving quality of
      life, should be available to all those with chronic or incurable illness. Good
      nutrition is central to such care meeting patients' physical requirements and
      psychosocial needs, thus helping them to maintain a sense of autonomy and
      normality while also promoting psychological comfort, communication, and social
      interaction. Many patients receiving palliative care experience difficulties in
      maintaining an appropriate food intake, which presents many challenges for
      practitioners and requires an understanding of both nutrition and patient needs. 
      This article describes the types of nutritional support that are available in the
      palliative care setting, as well as important ethical factors relevant to
      considerations of starting and withdrawing artificial nutrition.
FAU - Holmes, Susan
AU  - Holmes S
AD  - Faculty of Health and Social Care, Canterbury Christ Church University,
      Canterbury, Kent, UK. susan.holmes@canterbury.ac.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Palliat Nurs
JT  - International journal of palliative nursing
JID - 9506762
MH  - *Dietetics
MH  - *Eating
MH  - Humans
MH  - *Palliative Care
MH  - Quality of Life
EDAT- 2011/06/08 06:00
MHDA- 2011/07/23 06:00
CRDT- 2011/06/08 06:00
PHST- 2011/06/08 06:00 [entrez]
PHST- 2011/06/08 06:00 [pubmed]
PHST- 2011/07/23 06:00 [medline]
AID - 10.12968/ijpn.2011.17.5.217 [doi]
PST - ppublish
SO  - Int J Palliat Nurs. 2011 May;17(5):217-22. doi: 10.12968/ijpn.2011.17.5.217.


PMID- 21647040
OWN - NLM
STAT- MEDLINE
DCOM- 20110728
LR  - 20191112
IS  - 1750-8460 (Print)
IS  - 1750-8460 (Linking)
VI  - 72
IP  - 5
DP  - 2011 May
TI  - Do not attempt resuscitation orders, ethics and the Mental Capacity Act.
PG  - 259-63
FAU - Thomas, Ruth H
AU  - Thomas RH
AD  - Dorset County Hospital, Dorchester, Dorset, UK.
FAU - Schuster-Bruce, Martin
AU  - Schuster-Bruce M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Hosp Med (Lond)
JT  - British journal of hospital medicine (London, England : 2005)
JID - 101257109
SB  - IM
MH  - Cardiopulmonary Resuscitation/*ethics
MH  - Decision Making/*ethics
MH  - Humans
MH  - Informed Consent/*ethics
MH  - *Mental Competency
MH  - Resuscitation Orders/*ethics
EDAT- 2011/06/08 06:00
MHDA- 2011/07/29 06:00
CRDT- 2011/06/08 06:00
PHST- 2011/06/08 06:00 [entrez]
PHST- 2011/06/08 06:00 [pubmed]
PHST- 2011/07/29 06:00 [medline]
AID - 10.12968/hmed.2011.72.5.259 [doi]
PST - ppublish
SO  - Br J Hosp Med (Lond). 2011 May;72(5):259-63. doi: 10.12968/hmed.2011.72.5.259.


PMID- 21646893
OWN - NLM
STAT- MEDLINE
DCOM- 20111007
LR  - 20220321
IS  - 1932-8095 (Electronic)
IS  - 1932-8087 (Linking)
VI  - 16
IP  - 4
DP  - 2011 Jul-Aug
TI  - Role ambiguity and role conflict in nurse case managers: an integrative review.
PG  - 182-96; quiz 197-8
LID - 10.1097/NCM.0b013e318218845b [doi]
AB  - PURPOSE/OBJECTIVES: The purpose of this integrative review is to critically
      examine the relationship between the transition from a direct caregiver to a
      nurse case manager role and the perceived levels of role ambiguity and role
      conflict. PRIMARY PRACTICE SETTING(S): Nurse case managers in acute care,
      postacute care, and managed care settings. FINDINGS/CONCLUSIONS: Nurses can
      expect to experience substantial role ambiguity and role conflict as they take on
      the case manager role, primarily because of inadequate role definition,
      unexpected ethical challenges, and lack of prior insight into the case manager
      role. Role ambiguity and role conflict may impact nurse case managers' job
      satisfaction and job performance. IMPLICATIONS FOR CASE MANAGEMENT PRACTICE:
      Well-designed broad-scale descriptive studies are needed to further explicate the
      relationship between transition from direct caregiver to nurse case manager roles
      and the experience of role ambiguity and role conflict. Nurses transitioning from
      direct caregiver to nurse case manager roles should be systematically prepared to
      identify and manage specific ethical challenges commonly encountered by case
      managers. Further development of a nursing theoretical foundation for case
      management would be very useful in helping caregivers understand that as case
      managers, they remain practicing nurses with all the inherent rights and
      responsibilities of professional nursing.
FAU - Smith, Amy C
AU  - Smith AC
AD  - Trumbull Memorial Hospital, Northside Medical Center, Ohio, USA.
      asmith616@roadrunner.com
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Prof Case Manag
JT  - Professional case management
JID - 101291585
MH  - *Caregivers
MH  - *Case Management
MH  - *Conflict, Psychological
MH  - Curriculum
MH  - Education, Nursing
MH  - Humans
MH  - Models, Nursing
MH  - *Nurse's Role
MH  - Nursing/*classification
MH  - Time Factors
EDAT- 2011/06/08 06:00
MHDA- 2011/10/08 06:00
CRDT- 2011/06/08 06:00
PHST- 2011/06/08 06:00 [entrez]
PHST- 2011/06/08 06:00 [pubmed]
PHST- 2011/10/08 06:00 [medline]
AID - 10.1097/NCM.0b013e318218845b [doi]
AID - 01269241-201107000-00006 [pii]
PST - ppublish
SO  - Prof Case Manag. 2011 Jul-Aug;16(4):182-96; quiz 197-8. doi:
      10.1097/NCM.0b013e318218845b.


PMID- 21646327
OWN - NLM
STAT- MEDLINE
DCOM- 20111212
LR  - 20191210
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 5
DP  - 2011 Sep
TI  - Protecting vulnerable research participants: a Foucault-inspired analysis of
      ethics committees.
PG  - 640-50
LID - 10.1177/0969733011403807 [doi]
AB  - History has demonstrated the necessity of protecting research participants.
      Research ethics are based on a concept of asymmetry of power, viewing the
      researcher as powerful and potentially dangerous and establishing ethics
      committees as external agencies in the field of research. We argue in favour of
      expanding this perspective on relationships of power to encompass the ethics
      committees as one among several actors that exert power and that act in a
      relational interplay with researchers and participants. We employ Michel
      Foucault's ideas of power as an omnipresent force which is dynamic and unstable, 
      as well as the notion that knowledge and power are inextricably intertwined. The 
      article discusses how research ethics committees may affect academic freedom. In 
      addition it is pointed out that research participants could be harmed - not only 
      by unfortunate research practices, but also by being subjected to the protective 
      efforts of ethics monitoring bodies.
FAU - Juritzen, Truls I
AU  - Juritzen TI
AD  - University of Oslo, Norway. t.i.juritzen@medisin.uio.no
FAU - Grimen, Harald
AU  - Grimen H
FAU - Heggen, Kristin
AU  - Heggen K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110606
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - *Ethics Committees, Research
MH  - Ethics, Research
MH  - Humans
MH  - *Power, Psychological
MH  - *Research Subjects
EDAT- 2011/06/08 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/06/08 06:00
PHST- 2011/06/08 06:00 [entrez]
PHST- 2011/06/08 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 0969733011403807 [pii]
AID - 10.1177/0969733011403807 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Sep;18(5):640-50. doi: 10.1177/0969733011403807. Epub 2011 Jun 
      6.


PMID- 21646324
OWN - NLM
STAT- MEDLINE
DCOM- 20120905
LR  - 20151119
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 19
IP  - 3
DP  - 2012 May
TI  - Nursing under the influence: a relational ethics perspective.
PG  - 380-9
LID - 10.1177/0969733011406767 [doi]
AB  - When nurses have active and untreated addictions, patient safety may be
      compromised and nurse-health endangered. Genuine responses are required to fulfil
      nurses' moral obligations to their patients as well as to their nurse-colleagues.
      Guided by core elements of relational ethics, the influences of nursing
      organizational responses along with the practice environment in shaping the
      situation are contemplated. This approach identifies the importance of
      consistency with nursing values, acknowledges nurses interdependence, and
      addresses the role of nursing organization as moral agent. By examining the
      relational space, the tension between what appears to be opposing moral
      responsibilities may be healed. Ongoing discourse to identify authentic actions
      for the professional practice issue of nursing under the influence is called
      upon.
FAU - Kunyk, Diane
AU  - Kunyk D
AD  - University of Alberta, Canada. diane.kunyk@ualberta.ca
FAU - Austin, Wendy
AU  - Austin W
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110606
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - *Codes of Ethics
MH  - Disclosure/ethics
MH  - Employee Discipline/ethics
MH  - *Ethics, Nursing
MH  - Humans
MH  - Interprofessional Relations
MH  - Mandatory Reporting/ethics
MH  - *Moral Obligations
MH  - Nurse-Patient Relations/*ethics
MH  - Occupational Health Services/standards/supply & distribution
MH  - Organizational Policy
MH  - *Patient Safety/standards
MH  - Practice Patterns, Nurses'/*ethics
MH  - *Professional Impairment
MH  - Professional Role
MH  - Substance-Related Disorders/prevention & control/*psychology/rehabilitation
EDAT- 2011/06/08 06:00
MHDA- 2012/09/06 06:00
CRDT- 2011/06/08 06:00
PHST- 2011/06/08 06:00 [entrez]
PHST- 2011/06/08 06:00 [pubmed]
PHST- 2012/09/06 06:00 [medline]
AID - 0969733011406767 [pii]
AID - 10.1177/0969733011406767 [doi]
PST - ppublish
SO  - Nurs Ethics. 2012 May;19(3):380-9. doi: 10.1177/0969733011406767. Epub 2011 Jun
      6.


PMID- 21646323
OWN - NLM
STAT- MEDLINE
DCOM- 20111201
LR  - 20110726
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 4
DP  - 2011 Jul
TI  - Nursing strikes: an ethical perspective on the US healthcare community.
PG  - 596-605
LID - 10.1177/0969733011408050 [doi]
AB  - Recent labor disputes between registered nurses and hospitals in Minnesota,
      California, and Pennsylvania raise moral questions about nurses' professional
      obligations, nurses' right to collectively bargain to preserve or improve wages, 
      benefits, and working conditions, and patients' right to medical care. Deontology
      and consequentialism focus too narrowly on nurses and patients, and thus ignore
      the nature of the healthcare community as a system of competing interests. When
      considered in this context, nurses' strikes are shown to be consistent with this 
      system of competing interests, and thus are morally permissible.
FAU - Neiman, Paul
AU  - Neiman P
AD  - Philosophy Department, St Cloud State University, 3218 E 54th St, Minneapolis, MN
      55417, USA. pgneiman@stcloudstate.edu
LA  - eng
PT  - Journal Article
DEP - 20110606
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Community Health Services
MH  - *Ethics, Nursing
MH  - Humans
MH  - *Moral Obligations
MH  - *Nursing Staff, Hospital
MH  - Patient Rights
MH  - Social Responsibility
MH  - Strikes, Employee/*ethics
MH  - United States
EDAT- 2011/06/08 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/06/08 06:00
PHST- 2011/06/08 06:00 [entrez]
PHST- 2011/06/08 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 0969733011408050 [pii]
AID - 10.1177/0969733011408050 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Jul;18(4):596-605. doi: 10.1177/0969733011408050. Epub 2011 Jun
      6.


PMID- 21646322
OWN - NLM
STAT- MEDLINE
DCOM- 20111201
LR  - 20220330
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 4
DP  - 2011 Jul
TI  - The ethical component of professional competence in nursing: an analysis.
PG  - 571-82
LID - 10.1177/0969733011408041 [doi]
AB  - The purpose of this article is to initiate a philosophical discussion about the
      ethical component of professional competence in nursing from the perspective of
      Brazilian nurses. Specifically, this article discusses professional competence in
      nursing practice in the Brazilian health context, based on two different
      conceptual frameworks. The first framework is derived from the idealistic and
      traditional approach while the second views professional competence through the
      lens of historical and dialectical materialism theory. The philosophical analyses
      show that the idealistic view of professional competence differs greatly from
      practice. Combining nursing professional competence with philosophical
      perspectives becomes a challenge when ideals are opposed by the reality and
      implications of everyday nursing practice.
FAU - Paganini, Maria Cristina
AU  - Paganini MC
AD  - Federal University of Parana, Brazil. pagnine@brturbo.com.br
FAU - Yoshikawa Egry, Emiko
AU  - Yoshikawa Egry E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110606
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Brazil
MH  - *Ethics, Nursing
MH  - Humans
MH  - Philosophy, Nursing
MH  - *Professional Competence
EDAT- 2011/06/08 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/06/08 06:00
PHST- 2011/06/08 06:00 [entrez]
PHST- 2011/06/08 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 0969733011408041 [pii]
AID - 10.1177/0969733011408041 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Jul;18(4):571-82. doi: 10.1177/0969733011408041. Epub 2011 Jun 
      6.


PMID- 21646321
OWN - NLM
STAT- MEDLINE
DCOM- 20120319
LR  - 20220330
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 6
DP  - 2011 Nov
TI  - Engaging with children in research: Theoretical and practical implications of
      negotiating informed consent/assent.
PG  - 781-801
LID - 10.1177/0969733011401122 [doi]
AB  - At the outset of an ethnographic inquiry, we navigated national and international
      resources to search for theoretical and practical guidance on obtaining parents
      and children's informed consent/assent. While much theoretical guidance debating 
      ethical issues to children's participation in research was found, a paucity of
      published papers offering practical guidance on assent processes and/or visual
      representations of child assent forms and information sheets was discovered. The 
      purpose of this article is to describe our experiences, both theoretically and
      practically, of negotiating the process of obtaining informed consent and assent 
      with parents and children for a non-therapeutic qualitative research study. We
      hope this article instigates a platform for others to explicate their experience 
      and contributes to the construction of a coherent body of knowledge which will
      clearly delineate important elements that must be considered when negotiating
      children's agreement to participate in research.
FAU - Lambert, Veronica
AU  - Lambert V
AD  - School of Nursing, Dublin City University, Ireland. veronica.lambert@dcu.ie
FAU - Glacken, Michele
AU  - Glacken M
LA  - eng
PT  - Journal Article
DEP - 20110606
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Child
MH  - Guidelines as Topic
MH  - Humans
MH  - *Informed Consent By Minors/ethics
MH  - Negotiating/*methods
MH  - *Nurse-Patient Relations
MH  - Nursing Methodology Research
MH  - Nursing Research
MH  - *Professional-Family Relations
MH  - Qualitative Research
MH  - Research Subjects
MH  - *Third-Party Consent/ethics
EDAT- 2011/06/08 06:00
MHDA- 2012/03/20 06:00
CRDT- 2011/06/08 06:00
PHST- 2011/06/08 06:00 [entrez]
PHST- 2011/06/08 06:00 [pubmed]
PHST- 2012/03/20 06:00 [medline]
AID - 0969733011401122 [pii]
AID - 10.1177/0969733011401122 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Nov;18(6):781-801. doi: 10.1177/0969733011401122. Epub 2011 Jun
      6.


PMID- 21646320
OWN - NLM
STAT- MEDLINE
DCOM- 20120319
LR  - 20181201
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 6
DP  - 2011 Nov
TI  - Barriers and facilitators to consulting hospital clinical ethics committees.
PG  - 767-80
LID - 10.1177/0969733011403808 [doi]
AB  - Hospitals in many countries have had clinical ethics committees for over 20
      years. Despite this, there has been little research to evaluate these committees 
      and growing evidence that they are underutilized. To address this gap, we
      investigated the question 'What are the barriers and facilitators nurses and
      physicians perceive in consulting their hospital ethics committee?' Thirty-four
      nurses, 10 nurse managers and 31 physicians working at four Canadian hospitals
      were interviewed using a semi-structured interview guide as part of a larger
      investigation. We used content analysis of the interview data related to barriers
      and facilitators to use of hospital ethics committees to identify nine categories
      of barriers and nine categories of facilitators. These categories as well as
      their subcategories are discussed and those specific to nurses or physicians are 
      identified. The need to increase health professionals' use of clinical ethics
      committees through reducing barriers and maximizing facilitators is discussed.
FAU - Gaudine, Alice
AU  - Gaudine A
AD  - School of Nursing, Memorial University of Newfoundland, St. John's, Newfoundland,
      Canada. agaudine@mun.ca
FAU - Lamb, Marianne
AU  - Lamb M
FAU - LeFort, Sandra M
AU  - LeFort SM
FAU - Thorne, Linda
AU  - Thorne L
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110606
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - *Attitude of Health Personnel
MH  - Canada
MH  - Ethics Committees, Clinical/*statistics & numerical data
MH  - Ethics Consultation/*statistics & numerical data
MH  - Humans
MH  - Interprofessional Relations
MH  - Medical Staff, Hospital/*psychology
MH  - Nursing Methodology Research
MH  - Nursing Staff, Hospital/*psychology
MH  - Qualitative Research
EDAT- 2011/06/08 06:00
MHDA- 2012/03/20 06:00
CRDT- 2011/06/08 06:00
PHST- 2011/06/08 06:00 [entrez]
PHST- 2011/06/08 06:00 [pubmed]
PHST- 2012/03/20 06:00 [medline]
AID - 0969733011403808 [pii]
AID - 10.1177/0969733011403808 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Nov;18(6):767-80. doi: 10.1177/0969733011403808. Epub 2011 Jun 
      6.


PMID- 21645791
OWN - NLM
STAT- MEDLINE
DCOM- 20111101
LR  - 20110607
IS  - 1557-9840 (Electronic)
IS  - 0095-5108 (Linking)
VI  - 38
IP  - 2
DP  - 2011 Jun
TI  - An ethical framework for the informed consent process for trial of labor after
      cesarean delivery.
PG  - 227-31
LID - 10.1016/j.clp.2011.03.002 [doi]
AB  - In 2010, a National Institutes of Health Consensus Panel and the American College
      of Obstetricians and Gynecologists issued updated statements on trial of labor
      after cesarean delivery (TOLAC). This article presents an ethical framework for
      the informed consent process for TOLAC. Three conclusions are reached. For women 
      with one previous low transverse incision, TOLAC and elective repeat cesarean
      delivery should be offered. Obstetricians should recommend against TOLAC when a
      pregnant woman has had a previous classical incision. TOLAC after two previous
      low transverse incisions may be offered provided that the informed consent
      process presents the uncertainties of the evidence.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Chervenak, Frank A
AU  - Chervenak FA
AD  - Department of Obstetrics and Gynecology, New York-Presbyterian Hospital - Weill
      Cornell Medical College, New York, NY 10065, USA. fac2001@med.cornell.edu
FAU - McCullough, Laurence B
AU  - McCullough LB
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Perinatol
JT  - Clinics in perinatology
JID - 7501306
SB  - IM
MH  - Female
MH  - Fetus
MH  - Human Rights
MH  - Humans
MH  - Informed Consent/*ethics/legislation & jurisprudence
MH  - Pregnancy
MH  - Risk Factors
MH  - *Trial of Labor
MH  - Vaginal Birth after Cesarean/*ethics/legislation & jurisprudence
EDAT- 2011/06/08 06:00
MHDA- 2011/11/02 06:00
CRDT- 2011/06/08 06:00
PHST- 2011/06/08 06:00 [entrez]
PHST- 2011/06/08 06:00 [pubmed]
PHST- 2011/11/02 06:00 [medline]
AID - S0095-5108(11)00023-6 [pii]
AID - 10.1016/j.clp.2011.03.002 [doi]
PST - ppublish
SO  - Clin Perinatol. 2011 Jun;38(2):227-31. doi: 10.1016/j.clp.2011.03.002.


PMID- 21645735
OWN - NLM
STAT- MEDLINE
DCOM- 20110929
LR  - 20191210
IS  - 1873-3573 (Electronic)
IS  - 0039-9140 (Linking)
VI  - 85
IP  - 1
DP  - 2011 Jul 15
TI  - Comparison of biosensor platforms for surface plasmon resonance based detection
      of paralytic shellfish toxins.
PG  - 519-26
LID - 10.1016/j.talanta.2011.04.033 [doi]
AB  - Paralytic shellfish poisoning (PSP) toxins are produced by certain marine
      dinoflagellates and may accumulate in bivalve molluscs through filter feeding.
      The Mouse Bioassay (MBA) is the internationally recognised reference method of
      analysis, but it is prone to technical difficulties and regarded with increasing 
      disapproval due to ethical reasons. As such, alternative methods are required. A 
      rapid surface plasmon resonance (SPR) biosensor inhibition assay was developed to
      detect PSP toxins in shellfish by employing a saxitoxin polyclonal antibody
      (R895). Using an assay developed for and validated on the Biacore Q biosensor
      system, this project focused on transferring the assay to a high-throughput,
      Biacore T100 biosensor in another laboratory. This was achieved using a prototype
      PSP toxin kit and recommended assay parameters based on the Biacore Q method. A
      monoclonal antibody (GT13A) was also assessed. Even though these two instruments 
      are based on SPR principles, they vary widely in their mode of operation
      including differences in the integrated mu-fluidic cartridges, autosampler
      system, and sensor chip compatibilities. Shellfish samples (n=60), extracted
      using a simple, rapid procedure, were analysed using each platform, and results
      were compared to AOAC high performance liquid chromatography (HPLC) and MBA
      methods. The overall agreement, based on statistical 2x2 comparison tables,
      between each method ranged from 85% to 94.4% using R895 and 77.8% to 100% using
      GT13A. The results demonstrated that the antibody based assays with high
      sensitivity and broad specificity to PSP toxins can be applied to different
      biosensor platforms.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Haughey, Simon A
AU  - Haughey SA
AD  - Institute of Agri-Food and Land Use (IAFLU), Queen's University Belfast, David
      Keir Building, Stranmillis Road, Belfast, Northern Ireland, BT9 5AG, UK.
      s.a.haughey@qub.ac.uk
FAU - Campbell, Katrina
AU  - Campbell K
FAU - Yakes, Betsy J
AU  - Yakes BJ
FAU - Prezioso, Samantha M
AU  - Prezioso SM
FAU - Degrasse, Stacey L
AU  - Degrasse SL
FAU - Kawatsu, Kentaro
AU  - Kawatsu K
FAU - Elliott, Christopher T
AU  - Elliott CT
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110417
PL  - Netherlands
TA  - Talanta
JT  - Talanta
JID - 2984816R
RN  - 0 (Antibodies)
RN  - 0 (Antibodies, Monoclonal)
RN  - 35523-89-8 (Saxitoxin)
SB  - IM
MH  - Animals
MH  - Antibodies
MH  - Antibodies, Monoclonal/biosynthesis
MH  - Biosensing Techniques/*methods/standards
MH  - Mice
MH  - Saxitoxin/*analysis
MH  - Sensitivity and Specificity
MH  - *Shellfish Poisoning
MH  - Surface Plasmon Resonance/*instrumentation/methods/standards
MH  - Toxicity Tests
EDAT- 2011/06/08 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/06/08 06:00
PHST- 2011/02/16 00:00 [received]
PHST- 2011/04/05 00:00 [revised]
PHST- 2011/04/11 00:00 [accepted]
PHST- 2011/06/08 06:00 [entrez]
PHST- 2011/06/08 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - S0039-9140(11)00347-X [pii]
AID - 10.1016/j.talanta.2011.04.033 [doi]
PST - ppublish
SO  - Talanta. 2011 Jul 15;85(1):519-26. doi: 10.1016/j.talanta.2011.04.033. Epub 2011 
      Apr 17.


PMID- 21645188
OWN - NLM
STAT- MEDLINE
DCOM- 20140110
LR  - 20211020
IS  - 1369-7625 (Electronic)
IS  - 1369-6513 (Linking)
VI  - 16
IP  - 2
DP  - 2013 Jun
TI  - Blueprint for a deliberative public forum on biobanking policy: were theoretical 
      principles achievable in practice?
PG  - 211-24
LID - 10.1111/j.1369-7625.2011.00701.x [doi]
AB  - BACKGROUND: Public deliberation is recommended for obtaining citizen input to
      policy development when policies involve contested ethical dimensions, diverse
      perspectives on how to trade-off competing public interests and low public
      awareness of these perspectives. Several norms have been proposed for the design 
      of deliberative methods. Evidence is scarce regarding whether such norms are
      achievable in practice. PURPOSE: This paper refers to principles of deliberative 
      democracy theory to describe a deliberative public forum on biobanking. Practical
      challenges and contextual facilitators of achieving deliberative ideals are
      discussed, along with factors that influenced use of the forum output in policy
      development. METHOD: The forum ran for 4 days over two weekends in Perth, Western
      Australia. Key methodological features were socio-demographic stratification to
      randomly recruit a mini-public of citizens for discursive representation,
      provision of information inclusive of diverse perspectives and framed for
      difference, provision of a fair way for reasoning and collective decision making 
      and adoption of processes to achieve publicity, accountability and independence
      from undue institutional influence. RESULTS: Most design principles were achieved
      in practice, with the fundamental exception of representativeness. Factors
      influencing these outcomes, and the use of deliberated outputs to develop policy,
      included institutional characteristics, the design involvement of deliberative
      experts and quality of the outputs when compared to other consultation methods.
      CONCLUSIONS: Public deliberations can achieve design ideals and influence
      (ethics-based) public health policy. The representation of 'hard to reach'
      citizens and their views needs further consideration, particularly as this
      relates to the procedural legitimacy of ethical analyses and the just inclusion
      of deliberative citizen advice within the broader policy-making process.
CI  - (c) 2011 John Wiley & Sons Ltd.
FAU - Molster, Caron
AU  - Molster C
AD  - Office of Population Health Genomics, Department of Health, Perth, WA 6849, USA. 
      caron.molster@health.wa.gov.au
FAU - Maxwell, Susannah
AU  - Maxwell S
FAU - Youngs, Leanne
AU  - Youngs L
FAU - Kyne, Gaenor
AU  - Kyne G
FAU - Hope, Fiona
AU  - Hope F
FAU - Dawkins, Hugh
AU  - Dawkins H
FAU - O'Leary, Peter
AU  - O'Leary P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110607
PL  - England
TA  - Health Expect
JT  - Health expectations : an international journal of public participation in health 
      care and health policy
JID - 9815926
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Biological Specimen Banks/*organization & administration
MH  - *Community Participation
MH  - Female
MH  - Health Policy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Policy Making
MH  - Public Opinion
MH  - Social Responsibility
MH  - Western Australia
MH  - Young Adult
PMC - PMC5060653
EDAT- 2011/06/08 06:00
MHDA- 2014/01/11 06:00
CRDT- 2011/06/08 06:00
PHST- 2011/06/08 06:00 [entrez]
PHST- 2011/06/08 06:00 [pubmed]
PHST- 2014/01/11 06:00 [medline]
AID - 10.1111/j.1369-7625.2011.00701.x [doi]
PST - ppublish
SO  - Health Expect. 2013 Jun;16(2):211-24. doi: 10.1111/j.1369-7625.2011.00701.x. Epub
      2011 Jun 7.


PMID- 21644078
OWN - NLM
STAT- MEDLINE
DCOM- 20111011
LR  - 20201209
IS  - 0374-9096 (Print)
IS  - 0374-9096 (Linking)
VI  - 45
IP  - 2
DP  - 2011 Apr
TI  - [Investigation of interleukin-10, tumor necrosis factor-alpha and
      interferon-gamma expression in experimental model of pulmonary aspergillosis].
PG  - 344-52
AB  - Pulmonary aspergillosis which is an important opportunistic infection in
      neutropenic patients, is usually caused by Aspergillus fumigatus. Since the
      pathogenesis of disease is not well understood, the main proposed mechanism is
      thought to be cell-mediated immunity and cytokine response. The aim of this study
      was to investigate the local production of cytokines in the lung tissues of rats 
      with experimentally developed aspergillosis, by reverse transcriptase-polymerase 
      chain reaction (RT-PCR). A total of 33 Wistar albino type rats were included in
      the study with the consent of Experimental Animal Ethics Committee. Twenty-five
      of the rats were infected with A.fumigatus by intratracheal way, while 8 animals 
      were used as controls. The presence of A.fumigatus in the lung tissues of
      infected rats was confirmed with the use of quantitative culture and histologic
      staining methods. RNA isolation from the lung tissue samples of both groups were 
      performed by a commercial kit (Qiagen, Germany). After obtaining complementary
      DNAs from the genomic RNAs, in-house qualitative and quantitative (real-time) PCR
      methods were used to amplify the target regions for interleukin-10 (IL-10), tumor
      necrosis factor-alpha (TNF-?) and interferon-gamma (IFN-?) by using specific
      primers (Tib Molbiol, Germany). Mean mRNA levels achieved by real-time PCR for
      IL-10, TNF-? and IFN-? in aspergillosis group were 6.5 x 106 copies/ml, 7.9 x 105
      copies/ml and 2.2 x 103 copies/ml, respectively, while those values in control
      group were 4.3 x 102 copies/ml, 5.6 x 103 copies/ml and 1.3 x 102 copies/ml,
      respectively. Our data indicated that rat model of aspergillosis was associated
      with significantly increased expression of mRNA encoding IL-10 and TNF-? than
      controls (p< 0.05), however there was no statistically significant difference
      between the groups with respect to IFN-? expression (p= 0.53). In conclusion, the
      production of proinflammatory cytokines which mediate the influx of phagocytic
      cells might account for the localization of Aspergillus infection to the upper
      respiratory tract. The up-regulation of the expression of the immunomodulatory
      cytokine TNF-? and IL-10 in lung tissue from infected rats might be important to 
      limit the extent of local tissue destruction, but might also account for the fact
      that infected rats are generally unable to clear the infection spontaneously.
FAU - Caglar, Kayhan
AU  - Caglar K
AD  - Gazi University Faculty of Medicine, Department of Medical Microbiology, Ankara, 
      Turkey.
FAU - Kalkanci, Ayse
AU  - Kalkanci A
FAU - Fidan, Isil
AU  - Fidan I
FAU - Aydogan, Sibel
AU  - Aydogan S
FAU - Hizel, Kenan
AU  - Hizel K
FAU - Dizbay, Murat
AU  - Dizbay M
FAU - Poyraz, Aylar
AU  - Poyraz A
FAU - Kustimur, Semra
AU  - Kustimur S
LA  - tur
PT  - Journal Article
TT  - Deneysel Pulmoner Aspergilloz Modelinde Interlokin-10, Tumor Nekroz Faktoru-alfa 
      ve Interferon-gama Ifadelenmesinin Arastirilmasi
PL  - Turkey
TA  - Mikrobiyol Bul
JT  - Mikrobiyoloji bulteni
JID - 7503830
RN  - 0 (RNA, Messenger)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Aspergillus fumigatus/genetics/*immunology/isolation & purification
MH  - Disease Models, Animal
MH  - Female
MH  - Gene Expression Regulation, Fungal
MH  - Interferon-gamma/*analysis/genetics
MH  - Interleukin-10/*analysis/genetics
MH  - Lung/*immunology/microbiology
MH  - Pulmonary Aspergillosis/*immunology
MH  - RNA, Messenger/isolation & purification/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Tumor Necrosis Factor-alpha/*analysis/genetics
EDAT- 2011/06/07 06:00
MHDA- 2011/10/12 06:00
CRDT- 2011/06/07 06:00
PHST- 2011/06/07 06:00 [entrez]
PHST- 2011/06/07 06:00 [pubmed]
PHST- 2011/10/12 06:00 [medline]
PST - ppublish
SO  - Mikrobiyol Bul. 2011 Apr;45(2):344-52.


PMID- 21643981
OWN - NLM
STAT- MEDLINE
DCOM- 20110929
LR  - 20211020
IS  - 1432-1203 (Electronic)
IS  - 0340-6717 (Linking)
VI  - 130
IP  - 3
DP  - 2011 Sep
TI  - Population biobanks and returning individual research results: mission impossible
      or new directions?
PG  - 393-401
LID - 10.1007/s00439-011-1021-x [doi]
AB  - Historically, large-scale longitudinal genomic research studies have not returned
      individual research results to their participants, as these studies are not
      intended to find clinically significant information for individuals, but to
      produce 'generalisable' knowledge for future research. However, this stance is
      now changing. Commentators now argue that there is an ethical imperative to
      return clinically significant results and individuals are now expressing a desire
      to have them. This shift reflects societal changes, such as the rise of social
      networking and an increased desire to participate in medical decision-making, as 
      well as a greater awareness of genetic information and the increasing ability of 
      clinicians to use this information in health care treatment. This paper will
      discuss the changes that have prompted genomic research studies to reconsider
      their position and presents examples of projects that are actively engaged in
      returning individual research results.
FAU - Wallace, Susan E
AU  - Wallace SE
AD  - Department of Health Sciences, University of Leicester, 212a Adrian Building,
      University Road, Leicester LE1 7RH, UK. sew40@le.ac.uk
FAU - Kent, Alastair
AU  - Kent A
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110605
PL  - Germany
TA  - Hum Genet
JT  - Human genetics
JID - 7613873
SB  - IM
MH  - *Biological Specimen Banks/trends
MH  - Forecasting
MH  - Genetic Privacy
MH  - *Patient Access to Records
MH  - Public Opinion
MH  - Registries
MH  - Research/*trends
EDAT- 2011/06/07 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/06/07 06:00
PHST- 2011/04/27 00:00 [received]
PHST- 2011/05/25 00:00 [accepted]
PHST- 2011/06/07 06:00 [entrez]
PHST- 2011/06/07 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - 10.1007/s00439-011-1021-x [doi]
PST - ppublish
SO  - Hum Genet. 2011 Sep;130(3):393-401. doi: 10.1007/s00439-011-1021-x. Epub 2011 Jun
      5.


PMID- 21642906
OWN - NLM
STAT- MEDLINE
DCOM- 20111230
LR  - 20110805
IS  - 1559-713X (Electronic)
IS  - 1559-2332 (Linking)
VI  - 6
IP  - 4
DP  - 2011 Aug
TI  - Design and evaluation of simulation scenarios for a program introducing patient
      safety, teamwork, safety leadership, and simulation to healthcare leaders and
      managers.
PG  - 231-8
LID - 10.1097/SIH.0b013e31821da9ec [doi]
AB  - We developed a training program to introduce managers and informal leaders of
      healthcare organizations to key concepts of teamwork, safety leadership, and
      simulation to motivate them to act as leaders to improve safety within their
      sphere of influence. This report describes the simulation scenario and debriefing
      that are core elements of that program. Twelve teams of clinician and
      nonclinician managers were selected from a larger set of volunteers to
      participate in a 1-day, multielement training program. Two simulation exercises
      were developed: one for teams of nonclinicians and the other for clinicians or
      mixed groups. The scenarios represented two different clinical situations, each
      designed to engage participants in discussions of their safety leadership and
      teamwork issues immediately after the experience. In the scenarios for
      nonclinicians, participants conducted an anesthetic induction and then managed an
      ethical situation. The scenario for clinicians simulated a consulting visit to an
      emergency room that evolved into a problem-solving challenge. Participants in
      this scenario had a limited time to prepare advice for hospital leadership on how
      to improve observed safety and cultural deficiencies. Debriefings after both
      types of scenarios were conducted using principles of "debriefing with good
      judgment." We assessed the relevance and impact of the program by analyzing
      participant reactions to the simulation through transcript data and facilitator
      observations as well as a postcourse questionnaire. The teams generally reported 
      positive perceptions of the relevance and quality of the simulation with varying 
      types and degrees of impact on their leadership and teamwork behaviors. These
      kinds of clinical simulation exercises can be used to teach healthcare leaders
      and managers safety leadership and teamwork skills and behaviors.
FAU - Cooper, Jeffrey B
AU  - Cooper JB
AD  - Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General 
      Hospital and Massachusetts General Physicians Organization, Boston, MA, USA.
      jcooper@partners.org
FAU - Singer, Sara J
AU  - Singer SJ
FAU - Hayes, Jennifer
AU  - Hayes J
FAU - Sales, Michael
AU  - Sales M
FAU - Vogt, Jay W
AU  - Vogt JW
FAU - Raemer, Daniel
AU  - Raemer D
FAU - Meyer, Gregg S
AU  - Meyer GS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Simul Healthc
JT  - Simulation in healthcare : journal of the Society for Simulation in Healthcare
JID - 101264408
SB  - IM
MH  - *Cooperative Behavior
MH  - Emergency Service, Hospital
MH  - Health Facility Administrators/*education
MH  - Health Personnel/*education
MH  - Humans
MH  - *Leadership
MH  - Medical Errors/prevention & control
MH  - New England
MH  - Problem-Based Learning
MH  - Program Development
MH  - *Safety Management
MH  - Teaching/*methods
EDAT- 2011/06/07 06:00
MHDA- 2011/12/31 06:00
CRDT- 2011/06/07 06:00
PHST- 2011/06/07 06:00 [entrez]
PHST- 2011/06/07 06:00 [pubmed]
PHST- 2011/12/31 06:00 [medline]
AID - 10.1097/SIH.0b013e31821da9ec [doi]
PST - ppublish
SO  - Simul Healthc. 2011 Aug;6(4):231-8. doi: 10.1097/SIH.0b013e31821da9ec.


PMID- 21642904
OWN - NLM
STAT- MEDLINE
DCOM- 20120206
LR  - 20111006
IS  - 1559-713X (Electronic)
IS  - 1559-2332 (Linking)
VI  - 6
IP  - 5
DP  - 2011 Oct
TI  - Nontechnical skills assessment after simulation-based continuing medical
      education.
PG  - 255-9
LID - 10.1097/SIH.0b013e31821dfd05 [doi]
AB  - INTRODUCTION: Human factors have been identified as root causes of human error in
      medicine. The "Anesthetists' Non-Technical Skills (ANTS) system" evaluates the
      effect of simulation training and debriefing on nontechnical skills (NTS).
      Studies suggest that residents' NTS may improve after simulation training but the
      effect on NTS of practicing anesthesiologists is unclear. The purpose of this
      study was to determine whether high-fidelity simulation training and debriefing
      improved the NTS of practicing anesthesiologists using the ANTS tool. METHODS: In
      a previous study, 67 practicing anesthesiologists managed a 45-minute
      standardized anesthetic case using high-fidelity simulation and returned 5 to 9
      months later to manage a second case. After Research Ethics Board approval, two
      blinded video reviewers, trained in the use of the ANTS system, evaluated
      archived videotapes of the 59 subjects who completed both sessions. Results were 
      analyzed with a mixed-design analysis of variance. Interrater reliability was
      calculated using the intraclass correlation coefficient. RESULTS: Interrater
      reliability for the ANTS scoring was 0.436, P < 0.05. Overall, ANTS scores
      improved approximately 5% from session 1 to 2 (P < 0.01), but there was no effect
      due to debriefing. The situational awareness ANTS category showed a statistically
      significant effect of debriefing (P < 0.05). CONCLUSIONS: The relatively short
      simulation intervention, the length of time until the posttest was completed,
      well-developed NTS in practicing physicians, and a tool that might not be the
      optimal method of measurement may all account for the lack of improvement in NTS 
      of practicing anesthesiologists as demonstrated in this study.
FAU - Morgan, Pamela J
AU  - Morgan PJ
AD  - Department of Anesthesia, Sunnybrook Health Sciences Centre, University of
      Toronto, ON, Canada. pam.morgan@utoronto.ca
FAU - Kurrek, Matt M
AU  - Kurrek MM
FAU - Bertram, Susan
AU  - Bertram S
FAU - LeBlanc, Vicki
AU  - LeBlanc V
FAU - Przybyszewski, Teresa
AU  - Przybyszewski T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Simul Healthc
JT  - Simulation in healthcare : journal of the Society for Simulation in Healthcare
JID - 101264408
SB  - IM
MH  - Adult
MH  - Anesthesiology/*education
MH  - *Clinical Competence
MH  - *Computer Simulation
MH  - Cooperative Behavior
MH  - Decision Making
MH  - Education, Medical, Continuing/*methods
MH  - Humans
MH  - Middle Aged
MH  - Patient Care Team
MH  - Videotape Recording
EDAT- 2011/06/07 06:00
MHDA- 2012/02/07 06:00
CRDT- 2011/06/07 06:00
PHST- 2011/06/07 06:00 [entrez]
PHST- 2011/06/07 06:00 [pubmed]
PHST- 2012/02/07 06:00 [medline]
AID - 10.1097/SIH.0b013e31821dfd05 [doi]
PST - ppublish
SO  - Simul Healthc. 2011 Oct;6(5):255-9. doi: 10.1097/SIH.0b013e31821dfd05.


PMID- 21642842
OWN - NLM
STAT- MEDLINE
DCOM- 20111019
LR  - 20110624
IS  - 1538-943X (Electronic)
IS  - 1058-2916 (Linking)
VI  - 57
IP  - 4
DP  - 2011 Jul-Aug
TI  - Ethical considerations for ventricular assist device support: a 10-point model.
PG  - 268-73
LID - 10.1097/MAT.0b013e3182223269 [doi]
AB  - The potential for long-term support on a ventricular assist device (VAD) in the
      bridge-to-transplant (BTT) and destination therapy (DT) settings has created
      unprecedented ethical challenges for patients and caregivers. Concerns include
      the patient's adaptation to life on a device and the ethical, clinical, and
      practical issues associated with living on mechanical support. On the basis of
      our experience treating 175 consecutive VAD patients, we have developed a model
      to address the ethical and psychosocial needs of patients undergoing VAD
      implantation. Patient preparation for VAD implantation encompasses three phases: 
      1) initial information regarding the physical events involved in implantation,
      risks and benefits of current device technology, and the use of VAD as a rescue
      device; 2) preimplant preparation including completion of advance directives
      specific to BTT/DT, competency determination, and identifying a patient
      spokesperson, multidisciplinary consultants, and cultural preferences regarding
      device withdrawal; and 3) VAD-specific end-of-life issues including plans for
      device replacement and palliative care with hospice or device withdrawal. This
      three-phase 10-point model addresses the ethical and psychosocial issues that
      should be discussed with patients undergoing VAD support.
FAU - Petrucci, Ralph J
AU  - Petrucci RJ
AD  - Department of Psychiatry, Drexel University College of Medicine/Hahnemann
      University Hospital, Philadelphia, Pennsylvania 19102, USA.
      Ralph.Petrucci@drexelmed.edu
FAU - Benish, Lynne A
AU  - Benish LA
FAU - Carrow, Barbara L
AU  - Carrow BL
FAU - Prato, Lisa
AU  - Prato L
FAU - Hankins, Shelley R
AU  - Hankins SR
FAU - Eisen, Howard J
AU  - Eisen HJ
FAU - Entwistle, John W
AU  - Entwistle JW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - ASAIO J
JT  - ASAIO journal (American Society for Artificial Internal Organs : 1992)
JID - 9204109
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cardiology/*ethics
MH  - Ethics, Medical
MH  - Female
MH  - Guidelines as Topic
MH  - Heart Failure/surgery
MH  - Heart Transplantation/ethics/*methods
MH  - Heart Ventricles/surgery
MH  - Heart-Assist Devices/*ethics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Models, Cardiovascular
MH  - Palliative Care
EDAT- 2011/06/07 06:00
MHDA- 2011/10/20 06:00
CRDT- 2011/06/07 06:00
PHST- 2011/06/07 06:00 [entrez]
PHST- 2011/06/07 06:00 [pubmed]
PHST- 2011/10/20 06:00 [medline]
AID - 10.1097/MAT.0b013e3182223269 [doi]
PST - ppublish
SO  - ASAIO J. 2011 Jul-Aug;57(4):268-73. doi: 10.1097/MAT.0b013e3182223269.


PMID- 21642335
OWN - NLM
STAT- MEDLINE
DCOM- 20111201
LR  - 20151119
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 4
DP  - 2011 Jul
TI  - Nasogastric feeding at the end of life: a virtue ethics approach.
PG  - 485-94
LID - 10.1177/0969733011403557 [doi]
AB  - The use of Nasogastric (NG) feeding in the provision of artificial nutrition and 
      hydration at the end of life has, for the most part, been regarded as futile by
      the medical community. This position has been led chiefly by prevailing medical
      data. In Singapore, however, there has been an increase in its utilization
      supported primarily by social, religious and cultural factors expressly to
      prolong life of the terminally ill patient. Here this article will seek to review
      the ethical and clinical impact of this treatment and provide some understanding 
      for such decisions in the light of the Duty of Palliative Care [DoPC].
      Complemented by virtue ethics theory, the DoPC highlights and seeks to realize
      the individual case specific goals of care that maximize comfort and quality of
      life of the patient in the face of rapid attenuation of treatment options and the
      eminence of the final outcome by considering each of these factors individually
      in order to provide the best outcome for the patient and the family.
FAU - Krishna, Lalit
AU  - Krishna L
AD  - National Cancer Centre, Singapore. lalit.krishna@nccs.com.sg
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110603
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Enteral Nutrition/*ethics
MH  - Ethical Theory
MH  - Ethics, Medical
MH  - Humans
MH  - Palliative Care/*ethics
MH  - Practice Patterns, Physicians'/*ethics
MH  - Singapore
MH  - Virtues
EDAT- 2011/06/07 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/06/07 06:00
PHST- 2011/06/07 06:00 [entrez]
PHST- 2011/06/07 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 0969733011403557 [pii]
AID - 10.1177/0969733011403557 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Jul;18(4):485-94. doi: 10.1177/0969733011403557. Epub 2011 Jun 
      3.


PMID- 21642334
OWN - NLM
STAT- MEDLINE
DCOM- 20111212
LR  - 20110906
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 5
DP  - 2011 Sep
TI  - Opt-out HIV testing: an ethical analysis of women's reproductive rights.
PG  - 734-42
LID - 10.1177/0969733011403555 [doi]
AB  - As the HIV epidemic continues to grow worldwide, women are increasingly and
      disproportionally affected. With the introduction of anti-retroviral medications 
      that have been found to effectively prevent perinatal transmission of HIV, the
      approach to HIV testing in pregnant women has grown increasingly more
      controversial. In recent years, the model of voluntary counseling and testing
      (VCT) has come into question with opt-out testing now advocated for by the
      Centers for Disease Control and occurring widely in pregnancy. The benefits of
      opt-out testing are numerous and may justify its use in replacing the VCT that
      many have come to see as insufficient. An ethical analysis of opt-out testing
      suggests it may be at odds with true informed consent and involve a degree of
      coercion that would not be allowed outside the prenatal setting. If opt-out
      testing is going to remain the standard of care then the ethical issues it raises
      must be made transparent. Strategies need to be designed for ensuring that HIV
      counseling and testing in pregnancy is done in accordance with ethical and
      reproductive rights principles.
FAU - Fields, Loren
AU  - Fields L
AD  - Planned Parenthood of Southern New England, 26 Women's Way, Meriden, CT 06511,
      USA. fields.loren@gmail.com
FAU - Kaplan, Clair
AU  - Kaplan C
LA  - eng
PT  - Journal Article
DEP - 20110603
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
CIN - Nurs Ethics. 2011 Sep;18(5):743-5. PMID: 21642331
MH  - Ethical Analysis
MH  - Female
MH  - HIV Infections/*diagnosis
MH  - Humans
MH  - Informed Consent/ethics
MH  - Mass Screening/*ethics
MH  - New England
MH  - *Patient Acceptance of Health Care
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/*diagnosis
MH  - Prenatal Care/ethics
MH  - Reproductive Rights/*ethics
MH  - Voluntary Programs/ethics
MH  - Women's Rights/*ethics
EDAT- 2011/06/07 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/06/07 06:00
PHST- 2011/06/07 06:00 [entrez]
PHST- 2011/06/07 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 0969733011403555 [pii]
AID - 10.1177/0969733011403555 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Sep;18(5):734-42. doi: 10.1177/0969733011403555. Epub 2011 Jun 
      3.


PMID- 21642331
OWN - NLM
STAT- MEDLINE
DCOM- 20111212
LR  - 20181201
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 5
DP  - 2011 Sep
TI  - Commentary on 'Opt-out HIV testing: an ethical analysis of women's reproductive
      rights'.
PG  - 743-5
LID - 10.1177/0969733011404342 [doi]
FAU - Seloilwe, Esther Salang
AU  - Seloilwe ES
LA  - eng
PT  - Editorial
PT  - Comment
DEP - 20110603
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
CON - Nurs Ethics. 2011 Sep;18(5):734-42. PMID: 21642334
MH  - Female
MH  - HIV Infections/*diagnosis
MH  - Humans
MH  - Mass Screening/*ethics
MH  - *Patient Acceptance of Health Care
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/*diagnosis
MH  - Reproductive Rights/*ethics
MH  - Women's Rights/*ethics
EDAT- 2011/06/07 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/06/07 06:00
PHST- 2011/06/07 06:00 [entrez]
PHST- 2011/06/07 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 0969733011404342 [pii]
AID - 10.1177/0969733011404342 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Sep;18(5):743-5. doi: 10.1177/0969733011404342. Epub 2011 Jun
      3.


PMID- 21642266
OWN - NLM
STAT- MEDLINE
DCOM- 20120209
LR  - 20111114
IS  - 1473-0480 (Electronic)
IS  - 0306-3674 (Linking)
VI  - 45
IP  - 15
DP  - 2011 Dec
TI  - Ethical practice and sports physician protection: a proposal.
PG  - 1170-3
LID - 10.1136/bjsm.2011.086124 [doi]
FAU - Holm, Soren
AU  - Holm S
FAU - McNamee, Michael J
AU  - McNamee MJ
FAU - Pigozzi, Fabio
AU  - Pigozzi F
LA  - eng
PT  - Editorial
DEP - 20110603
PL  - England
TA  - Br J Sports Med
JT  - British journal of sports medicine
JID - 0432520
SB  - IM
MH  - *Codes of Ethics
MH  - Confidentiality/ethics
MH  - Conflict of Interest
MH  - Disclosure/ethics
MH  - Ethics, Medical
MH  - Humans
MH  - Insurance/ethics
MH  - Interprofessional Relations/ethics
MH  - Physician's Role
MH  - Physician-Patient Relations/ethics
MH  - Professional Practice/ethics
MH  - Social Responsibility
MH  - Social Support
MH  - Sports Medicine/*ethics
EDAT- 2011/06/07 06:00
MHDA- 2012/02/10 06:00
CRDT- 2011/06/07 06:00
PHST- 2011/06/07 06:00 [entrez]
PHST- 2011/06/07 06:00 [pubmed]
PHST- 2012/02/10 06:00 [medline]
AID - bjsm.2011.086124 [pii]
AID - 10.1136/bjsm.2011.086124 [doi]
PST - ppublish
SO  - Br J Sports Med. 2011 Dec;45(15):1170-3. doi: 10.1136/bjsm.2011.086124. Epub 2011
      Jun 3.


PMID- 21640946
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20151119
IS  - 1768-3238 (Electronic)
IS  - 1631-0691 (Linking)
VI  - 334
IP  - 5-6
DP  - 2011 May
TI  - An ethical issue in biodiversity science: The monitoring of penguins with flipper
      bands.
PG  - 378-84
LID - 10.1016/j.crvi.2011.04.004 [doi]
AB  - Individual marking is essential to study the life-history traits of animals and
      to track them in all kinds of ecological, behavioural or physiological studies.
      Unlike other birds, penguins cannot be banded on their legs due to their leg
      joint anatomy and a band is instead fixed around a flipper. However, there is now
      detailed evidence that flipper-banding has a detrimental impact on individuals.
      It can severely injure flipper tissues, and the drag effect of their flipper
      bands results in a higher energy expenditure when birds are moving through the
      water. It also results in lower efficiency in foraging, since they require longer
      foraging trips, as well as in lower survival and lower breeding success.
      Moreover, due to the uncertainty of the rate of band loss, flipper bands induce a
      scientific bias. These problems, which obviously have serious ethical
      implications, can be avoided with alternative methods such as radiofrequency
      identification techniques.
CI  - Copyright (c) 2011 Academie des sciences. Published by Elsevier SAS. All rights
      reserved.
FAU - Le Maho, Yvon
AU  - Le Maho Y
AD  - Departement d'Ecologie, Physiologie et Ethologie, Institut Pluridisciplinaire
      Hubert Curien, Universite de Strasbourg, 23, rue Becquerel, 67087 Strasbourg
      cedex 02, France. yvon.lemaho@iphc.cnrs.fr
FAU - Saraux, Claire
AU  - Saraux C
FAU - Durant, Joel M
AU  - Durant JM
FAU - Viblanc, Vincent A
AU  - Viblanc VA
FAU - Gauthier-Clerc, Michel
AU  - Gauthier-Clerc M
FAU - Yoccoz, Nigel G
AU  - Yoccoz NG
FAU - Stenseth, Nils C
AU  - Stenseth NC
FAU - Le Bohec, Celine
AU  - Le Bohec C
LA  - eng
PT  - Journal Article
DEP - 20110523
PL  - France
TA  - C R Biol
JT  - Comptes rendus biologies
JID - 101140040
SB  - IM
MH  - Aging/physiology
MH  - Animals
MH  - *Biodiversity
MH  - Breeding
MH  - Energy Metabolism/physiology
MH  - Environmental Monitoring/economics/*ethics
MH  - Feeding Behavior
MH  - Observer Variation
MH  - Spheniscidae/*physiology
MH  - Stress, Psychological/physiopathology
MH  - Survival
MH  - Uncertainty
MH  - Wings, Animal
MH  - Wounds and Injuries/veterinary
EDAT- 2011/06/07 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/06/07 06:00
PHST- 2011/06/07 06:00 [entrez]
PHST- 2011/06/07 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - S1631-0691(11)00106-5 [pii]
AID - 10.1016/j.crvi.2011.04.004 [doi]
PST - ppublish
SO  - C R Biol. 2011 May;334(5-6):378-84. doi: 10.1016/j.crvi.2011.04.004. Epub 2011
      May 23.


PMID- 21640309
OWN - NLM
STAT- MEDLINE
DCOM- 20110928
LR  - 20110606
IS  - 1472-6491 (Electronic)
IS  - 1472-6483 (Linking)
VI  - 22
IP  - 7
DP  - 2011 Jun
TI  - Early pregnancy wastage: ethical considerations.
PG  - 692-700
LID - 10.1016/j.rbmo.2011.03.008 [doi]
AB  - Information on early embryo wastage is relevant for debating the status of human 
      embryos. Two main points of view confront each other. Theists hold that human
      embryos should be treated as human persons from the moment of conception because,
      even accepting that human beings are the fruit of evolution, they are part of a
      divine project. Without a developmental event prior to which the human embryo
      could not be considered a human being, embryos should be regarded as if they were
      human subjects. After all, if one believes in the resurrection of the dead, it
      makes no difference at what stage one's life ends. Secularists oppose the idea of
      granting absolute value to human life from its beginning because early human
      embryos lack individuality and sentience. Personifying embryos is morally absurd 
      because it would mean that countless human beings never had even the slightest
      chance to express their potential and, in the light of this catastrophic loss,
      one would expect early pregnancy wastage to have become an important research
      priority; this is not the case. In practical terms, most Western countries have
      legalized first-trimester abortion, de facto giving embryos a lower status than
      that of full person.
CI  - Copyright (c) 2011 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All
      rights reserved.
FAU - Benagiano, Giuseppe
AU  - Benagiano G
AD  - Department of Obstetrics, Gynaecology and Urology, Sapienza, University of Rome, 
      Policlinico Umberto I degrees , 00161 Rome, Italy. gbenagiano@libero.it
FAU - Mori, Maurizio
AU  - Mori M
FAU - Ford, Norman
AU  - Ford N
FAU - Grudzinskas, Gedis
AU  - Grudzinskas G
LA  - eng
PT  - Journal Article
DEP - 20110310
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
SB  - IM
MH  - *Beginning of Human Life
MH  - *Bioethical Issues
MH  - *Embryo Loss
MH  - Female
MH  - Humans
MH  - Pregnancy
MH  - *Religion and Science
EDAT- 2011/06/07 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/06/07 06:00
PHST- 2010/09/25 00:00 [received]
PHST- 2011/02/24 00:00 [revised]
PHST- 2011/03/02 00:00 [accepted]
PHST- 2011/06/07 06:00 [entrez]
PHST- 2011/06/07 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - S1472-6483(11)00161-1 [pii]
AID - 10.1016/j.rbmo.2011.03.008 [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2011 Jun;22(7):692-700. doi: 10.1016/j.rbmo.2011.03.008.
      Epub 2011 Mar 10.


PMID- 21640049
OWN - NLM
STAT- MEDLINE
DCOM- 20110824
LR  - 20170112
IS  - 0392-856X (Print)
IS  - 0392-856X (Linking)
VI  - 29
IP  - 3
DP  - 2011 May-Jun
TI  - Synovial colony-stimulating factor-1 mRNA expression in diffuse pigmented
      villonodular synovitis.
PG  - 547-50
AB  - OBJECTIVES: To delineate the molecular mechanisms underlying the process of the
      diffuse-type giant cell tumours, also called pigmented villonodular synovitis, a 
      rare, aggressive condition of the synovium, the knee synovial tissue expression
      of colony-stimulating factor-1 gene, as detected by real-time polymerase chain
      reaction, was compared between patients affected with pigmented villonodular knee
      synovitis and knee meniscal tears, or persistent gonoarthitis. METHODS: Multiple 
      synovial biopsies of the knee were performed by arthroscopy in five consecutive
      patients affected by diffuse pigmented villonodular knee synovitis and in 12
      patients affected by knee meniscal tears (n. 6) or persistent active gonarthritis
      (n. 6), recruited from the patients attending the Rheumatology Day Surgery
      Outpatient Clinic of the University of Padova Hospital. The ethics committee
      approved the study protocol and the participants signed consent statements after 
      being informed about the content of the study. The diagnosis was made on the
      basis of a histological examination. The colony-stimulating factor-1 gene
      expression was assessed by reverse transcription followed by real-time polymerase
      chain reaction. RESULTS: The detection by RT-PCR of synovial colony-stimulating
      factor-1 mRNA showed a wide spectrum of expression in the three groups of
      distinct knee joint disease affected patients, with significantly higher level of
      colony-stimulating factor-1 mRNA expression in synovial tissue of pigmented
      villonodular synovitis, in comparison to that of knee meniscal injuries and
      persistent gonoarthritis patients. CONCLUSIONS: Our findings point out to an
      important role of colony-stimulating factor-1 in pigmented villonodular knee
      synovitis disease process and support the idea that colony-stimulating
      factor-1/colony-stimulating factor-1 receptor interaction may represent a
      potential therapeutic target of this disease.
FAU - Molena, B
AU  - Molena B
AD  - Department of Clincal and Experimental Medicine, Italy.
FAU - Sfriso, P
AU  - Sfriso P
FAU - Oliviero, F
AU  - Oliviero F
FAU - Pagnin, E
AU  - Pagnin E
FAU - Teramo, A
AU  - Teramo A
FAU - Lunardi, Fr
AU  - Lunardi F
FAU - Stramare, R
AU  - Stramare R
FAU - Scanu, A
AU  - Scanu A
FAU - Nardacchione, R
AU  - Nardacchione R
FAU - Rubaltelli, L
AU  - Rubaltelli L
FAU - Calabrese, F
AU  - Calabrese F
FAU - Punzi, L
AU  - Punzi L
FAU - Fiocco, U
AU  - Fiocco U
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110630
PL  - Italy
TA  - Clin Exp Rheumatol
JT  - Clinical and experimental rheumatology
JID - 8308521
RN  - 0 (Biomarkers)
RN  - 0 (RNA, Messenger)
RN  - 81627-83-0 (Macrophage Colony-Stimulating Factor)
SB  - IM
MH  - Adult
MH  - Arthritis/metabolism/pathology
MH  - Biomarkers/metabolism
MH  - Biopsy
MH  - Female
MH  - Gene Expression Regulation
MH  - Humans
MH  - Macrophage Colony-Stimulating Factor/*metabolism
MH  - Male
MH  - Menisci, Tibial/metabolism/pathology
MH  - Middle Aged
MH  - RNA, Messenger/*metabolism
MH  - Synovial Membrane/*metabolism/pathology
MH  - Synovitis, Pigmented Villonodular/*metabolism/pathology
MH  - Tibial Meniscus Injuries
EDAT- 2011/06/07 06:00
MHDA- 2011/08/25 06:00
CRDT- 2011/06/07 06:00
PHST- 2010/11/16 00:00 [received]
PHST- 2011/01/13 00:00 [accepted]
PHST- 2011/06/07 06:00 [entrez]
PHST- 2011/06/07 06:00 [pubmed]
PHST- 2011/08/25 06:00 [medline]
AID - 4507 [pii]
PST - ppublish
SO  - Clin Exp Rheumatol. 2011 May-Jun;29(3):547-50. Epub 2011 Jun 30.


PMID- 21639927
OWN - NLM
STAT- MEDLINE
DCOM- 20110916
LR  - 20211020
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 12
DP  - 2011 Jun 4
TI  - Pilot randomized trial of therapeutic hypothermia with serial cranial ultrasound 
      and 18-22 month follow-up for neonatal encephalopathy in a low resource hospital 
      setting in Uganda: study protocol.
PG  - 138
LID - 10.1186/1745-6215-12-138 [doi]
AB  - BACKGROUND: There is now convincing evidence that in industrialized countries
      therapeutic hypothermia for perinatal asphyxial encephalopathy increases survival
      with normal neurological function. However, the greatest burden of perinatal
      asphyxia falls in low and mid-resource settings where it is unclear whether
      therapeutic hypothermia is safe and effective. AIMS: Under the UCL Uganda Women's
      Health Initiative, a pilot randomized controlled trial in infants with perinatal 
      asphyxia was set up in the special care baby unit in Mulago Hospital, a large
      public hospital with ~20,000 births in Kampala, Uganda to determine:(i) The
      feasibility of achieving consent, neurological assessment, randomization and
      whole body cooling to a core temperature 33-34 degrees C using water bottles(ii) 
      The temperature profile of encephalopathic infants with standard care(iii) The
      pattern, severity and evolution of brain tissue injury as seen on cranial
      ultrasound and relation with outcome(iv) The feasibility of neurodevelopmental
      follow-up at 18-22 months of age METHODS/DESIGN: Ethical approval was obtained
      from Makerere University and Mulago Hospital. All infants were in-born. Parental 
      consent for entry into the trial was obtained. Thirty-six infants were randomized
      either to standard care plus cooling (target rectal temperature of 33-34 degrees 
      C for 72 hrs, started within 3 h of birth) or standard care alone. All other
      aspects of management were the same. Cooling was performed using water bottles
      filled with tepid tap water (25 degrees C). Rectal, axillary, ambient and surface
      water bottle temperatures were monitored continuously for the first 80 h.
      Encephalopathy scoring was performed on days 1-4, a structured, scorable
      neurological examination and head circumference were performed on days 7 and 17. 
      Cranial ultrasound was performed on days 1, 3 and 7 and scored. Griffiths
      developmental quotient, head circumference, neurological examination and
      assessment of gross motor function were obtained at 18-22 months. DISCUSSION: We 
      will highlight differences in neonatal care and infrastructure that need to be
      taken into account when considering a large safety and efficacy RCT of
      therapeutic hypothermia in low and mid resource settings in the future. TRIAL
      REGISTRATION: Current controlled trials ISRCTN92213707.
FAU - Robertson, Nicola J
AU  - Robertson NJ
AD  - Institute for Women's Health, 86-96 Chenies Mews, University College London,
      London, UK. n.robertson@ucl.ac.uk
FAU - Hagmann, Cornelia F
AU  - Hagmann CF
FAU - Acolet, Dominique
AU  - Acolet D
FAU - Allen, Elizabeth
AU  - Allen E
FAU - Nyombi, Natasha
AU  - Nyombi N
FAU - Elbourne, Diana
AU  - Elbourne D
FAU - Costello, Anthony
AU  - Costello A
FAU - Jacobs, Ian
AU  - Jacobs I
FAU - Nakakeeto, Margaret
AU  - Nakakeeto M
FAU - Cowan, Frances
AU  - Cowan F
LA  - eng
SI  - ISRCTN/ISRCTN92213707
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110604
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
SB  - IM
MH  - Asphyxia Neonatorum/*complications/economics
MH  - Body Temperature Regulation
MH  - Cephalometry
MH  - Developing Countries/economics
MH  - Feasibility Studies
MH  - *Health Resources/economics
MH  - Hospital Costs
MH  - *Hospitals, Public/economics
MH  - Humans
MH  - *Hypothermia, Induced/economics
MH  - Hypoxia-Ischemia, Brain/*diagnostic
      imaging/economics/etiology/physiopathology/*therapy
MH  - Infant
MH  - Infant, Newborn
MH  - Motor Skills
MH  - Neurologic Examination
MH  - Pilot Projects
MH  - Predictive Value of Tests
MH  - Severity of Illness Index
MH  - Time Factors
MH  - Treatment Outcome
MH  - Uganda
MH  - Ultrasonography
PMC - PMC3127769
EDAT- 2011/06/07 06:00
MHDA- 2011/09/17 06:00
CRDT- 2011/06/07 06:00
PHST- 2010/09/28 00:00 [received]
PHST- 2011/06/04 00:00 [accepted]
PHST- 2011/06/07 06:00 [entrez]
PHST- 2011/06/07 06:00 [pubmed]
PHST- 2011/09/17 06:00 [medline]
AID - 1745-6215-12-138 [pii]
AID - 10.1186/1745-6215-12-138 [doi]
PST - epublish
SO  - Trials. 2011 Jun 4;12:138. doi: 10.1186/1745-6215-12-138.


PMID- 21639894
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1472-698X (Electronic)
IS  - 1472-698X (Linking)
VI  - 11
DP  - 2011 Jun 3
TI  - "If the patients decide not to tell what can we do?"- TB/HIV counsellors' dilemma
      on partner notification for HIV.
PG  - 6
LID - 10.1186/1472-698X-11-6 [doi]
AB  - BACKGROUND: There is a global consensus towards universal access to human
      immunodeficiency virus (HIV) services consequent to the increasing availability
      of antiretroviral therapy. However, to benefit from these services, knowledge of 
      one's HIV status is critical. Partner notification for HIV is an important
      component of HIV counselling because it is an effective strategy to prevent
      secondary transmission, and promote early diagnosis and prompt treatment of HIV
      patients' sexual partners. However, counsellors are often frustrated by the
      reluctance of HIV-positive patients to voluntarily notify their sexual partners. 
      This study aimed to explore tuberculosis (TB)/HIV counsellors' perspectives
      regarding confidentiality and partner notification. METHODS: Qualitative research
      interviews were conducted in the Northwest Region of Cameroon with 30 TB/HIV
      counsellors in 4 treatment centres, and 2 legal professionals between September
      and December 2009. Situational Analysis (positional map) was used for data
      analysis. RESULTS: Confidentiality issues were perceived to be handled properly
      despite concerns about patients' reluctance to report cases of violation due to
      apprehension of reprisals from health care staffs. All the respondents encouraged
      voluntary partner notification, and held four varying positions when confronted
      with patients who refused to voluntarily notify their partners. Position one
      focused on absolute respect of patients' autonomy; position two balanced between 
      the respect of patients' autonomy and their partners' safety; position three
      wished for protection of sexual partners at risk of HIV infection and legal
      protection for counsellors; and position four requested making HIV testing and
      partner notification routine processes. CONCLUSION: Counsellors regularly
      encounter ethical, legal and moral dilemmas between respecting patients'
      confidentiality and autonomy, and protecting patients' sexual partners at risk of
      HIV infection.This reflects the complexity of partner notification and
      demonstrates that no single approach is optimal, but instead certain contextual
      factors and a combination of different approaches should be considered.
      Meanwhile, adopting a human rights perspective in HIV programmes will balance the
      interests of both patients and their partners, and ultimately enhance universal
      access to HIV services.
FAU - Njozing, Barnabas N
AU  - Njozing BN
AD  - St, Mary Soledad Catholic Hospital, Mankon, Bamenda, P,O,Box 157, Cameroon.
      njozing.barnabas@epiph.umu.se.
FAU - Edin, Kerstin E
AU  - Edin KE
FAU - Sebastian, Miguel San
AU  - Sebastian MS
FAU - Hurtig, Anna-Karin
AU  - Hurtig AK
LA  - eng
PT  - Journal Article
DEP - 20110603
PL  - England
TA  - BMC Int Health Hum Rights
JT  - BMC international health and human rights
JID - 101088678
PMC - PMC3119031
EDAT- 2011/06/07 06:00
MHDA- 2011/06/07 06:01
CRDT- 2011/06/07 06:00
PHST- 2011/01/17 00:00 [received]
PHST- 2011/06/03 00:00 [accepted]
PHST- 2011/06/07 06:00 [entrez]
PHST- 2011/06/07 06:00 [pubmed]
PHST- 2011/06/07 06:01 [medline]
AID - 1472-698X-11-6 [pii]
AID - 10.1186/1472-698X-11-6 [doi]
PST - epublish
SO  - BMC Int Health Hum Rights. 2011 Jun 3;11:6. doi: 10.1186/1472-698X-11-6.


PMID- 21639740
OWN - NLM
STAT- MEDLINE
DCOM- 20111109
LR  - 20111117
IS  - 1934-9556 (Electronic)
IS  - 1934-9491 (Linking)
VI  - 49
IP  - 3
DP  - 2011 Jun
TI  - Standard of practice and Flynn Effect testimony in death penalty cases.
PG  - 131-40
LID - 10.1352/1934-9556-49.3.131 [doi]
AB  - The Flynn Effect is a well-established psychometric fact documenting substantial 
      increases in measured intelligence test performance over time. Flynn's (1984)
      review of the literature established that Americans gain approximately 0.3 points
      per year or 3 points per decade in measured intelligence. The accurate assessment
      and interpretation of intellectual functioning becomes critical in death penalty 
      cases that seek to determine whether an individual meets the criteria for
      intellectual disability and thereby is ineligible for execution under Atkins v.
      Virginia (2002) . We reviewed the literature on the Flynn Effect and demonstrated
      how failure to adjust intelligence test scores based on this phenomenon
      invalidates test scores and may be in violation of the Standards for Educational 
      and Psychological Testing as well as the "Ethical Principles for Psychologists
      and Code of Conduct." Application of the Flynn Effect and score adjustments for
      obsolete norms clearly is supported by science and should be implemented by
      practicing psychologists.
FAU - Gresham, Frank M
AU  - Gresham FM
AD  - Department of Psychology, Louisiana State University, Baton Rouge, LA 70803, USA.
      frankgresham@yahoo.com
FAU - Reschly, Daniel J
AU  - Reschly DJ
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Intellect Dev Disabil
JT  - Intellectual and developmental disabilities
JID - 101299965
SB  - IM
MH  - Capital Punishment/*legislation & jurisprudence
MH  - Humans
MH  - Intellectual Disability/*diagnosis
MH  - Intelligence Tests
MH  - Psychometrics
EDAT- 2011/06/07 06:00
MHDA- 2011/11/10 06:00
CRDT- 2011/06/07 06:00
PHST- 2011/06/07 06:00 [entrez]
PHST- 2011/06/07 06:00 [pubmed]
PHST- 2011/11/10 06:00 [medline]
AID - 10.1352/1934-9556-49.3.131 [doi]
PST - ppublish
SO  - Intellect Dev Disabil. 2011 Jun;49(3):131-40. doi: 10.1352/1934-9556-49.3.131.


PMID- 21639653
OWN - NLM
STAT- MEDLINE
DCOM- 20111118
LR  - 20110606
IS  - 1939-1536 (Electronic)
IS  - 0033-3204 (Linking)
VI  - 48
IP  - 2
DP  - 2011 Jun
TI  - Utilizing technological innovations to enhance psychotherapy supervision,
      training, and outcomes.
PG  - 103-8
LID - 10.1037/a0023381 [doi]
AB  - Recent technological advances in the use of the Internet and video technologies
      has greatly impacted the provision of psychotherapy and other clinical services
      as well as how the training of psychotherapists may be conducted. When utilized
      appropriately these technologies may provide greater access to needed services to
      include treatment, consultation, supervision, and training. Specific ethical
      challenges and pitfalls are discussed and recommendations are made for the
      ethical use of these technologies. Additionally, innovative practices from the
      seven articles in the special section that follows are highlighted and reviewed. 
      These articles present a number of innovations that can take psychotherapy
      training, research, supervision, and treatment forward toward increased
      effectiveness. Recommendations for integrating these innovations into ongoing
      practices are provided and for additional research to build on the important work
      of the authors in this special section are provided.
FAU - Barnett, Jeffrey E
AU  - Barnett JE
AD  - Department of Psychology, Loyola University Maryland, Baltimore, MD 21210, USA.
      jbarnett@loyola.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Psychotherapy (Chic)
JT  - Psychotherapy (Chicago, Ill.)
JID - 2984829R
SB  - IM
MH  - Confidentiality
MH  - Health Services Accessibility
MH  - Humans
MH  - *Inservice Training
MH  - *Internet
MH  - *Mentors
MH  - Professional-Patient Relations
MH  - Psychotherapeutic Processes
MH  - Psychotherapy/*education/*methods
MH  - *Remote Consultation
MH  - Risk Assessment
MH  - *Telephone
MH  - *Therapy, Computer-Assisted
MH  - *Video Recording
EDAT- 2011/06/07 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/06/07 06:00
PHST- 2011/06/07 06:00 [entrez]
PHST- 2011/06/07 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 2011-10776-001 [pii]
AID - 10.1037/a0023381 [doi]
PST - ppublish
SO  - Psychotherapy (Chic). 2011 Jun;48(2):103-8. doi: 10.1037/a0023381.


PMID- 21639017
OWN - NLM
STAT- MEDLINE
DCOM- 20110712
LR  - 20181201
IS  - 1075-2994 (Print)
VI  - 20
IP  - 1
DP  - 2011 Winter
TI  - The Stark Law in retrospect.
PG  - 15-48, 8 p preceding 1
AB  - Considering the ultimate goals of preventing the over-utilization of medical
      services and protecting the Medicare program, are the numerous phases of the
      Stark Law and their concomitant regulations effective; or, conversely, has the
      legislation served to impede entrepreneurialism among physicians to the detriment
      of innovations and better integration in the delivery of medical treatment? This 
      article endeavors to answer the above question through an analysis of the policy 
      goals behind the legislation; the evolution of its regulations; its effect on
      competitiveness in the field of medicine; and the ethical considerations
      implicated by the issue of physician self-referral. It further offers some
      proposals which attempt to address the problem of physician self-referral abuse
      while at the same time reducing the complexity and breadth of the Stark law and
      its regulations. The article concludes by noting that to truly change the
      practice of inappropriate self-referral as well as the culture of
      over-utilization, it is necessary not only to target specific relationships and
      practices prone to abuse, but to realign the financial incentives created by our 
      current payment mechanisms as well.
FAU - Sutton, Patrick A
AU  - Sutton PA
AD  - Chuhak & Tecson, P.C., LL.M., Health Law, Loyola University Chicago School of
      Law, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Health Law
JT  - Annals of health law
JID - 9306639
MH  - Health Policy
MH  - Health Services/statistics & numerical data
MH  - Medicare
MH  - Physician Self-Referral/ethics/*legislation & jurisprudence
MH  - United States
EDAT- 2011/06/07 06:00
MHDA- 2011/07/13 06:00
CRDT- 2011/06/07 06:00
PHST- 2011/06/07 06:00 [entrez]
PHST- 2011/06/07 06:00 [pubmed]
PHST- 2011/07/13 06:00 [medline]
PST - ppublish
SO  - Ann Health Law. 2011 Winter;20(1):15-48, 8 p preceding 1.


PMID- 21638257
OWN - NLM
STAT- MEDLINE
DCOM- 20110913
LR  - 20151119
IS  - 1012-5302 (Print)
IS  - 1012-5302 (Linking)
VI  - 24
IP  - 3
DP  - 2011 Jun
TI  - [The development of an instrument for the "evaluation of hospices from the
      bereaved family members perspective"].
PG  - 171-81
LID - 10.1024/1012-5302/a000118 [doi]
AB  - Inpatient hospice settings as facilities of health services are obliged to the
      quality assurance and internal quality development in Germany. The meaning of the
      patient's satisfaction as one of the indirect indicators for the judgement of
      nursing and care quality is indisputable by now. However, a subjective evaluation
      of the hospices by guests is practically and ethically problematic. An
      alternative approach is to investigate the views of bereaved relatives and close 
      friends after the guest's death. The present article describes the development of
      an inventory for the evaluation of inpatient hospice settings from the bereaved
      relatives' point of view in order to examine the satisfaction of family members
      with the end-of-life care their loved ones received. With help of the inventory
      the question should be answered how family members judge the end-of-life care
      which was given to them and their late family members by the hospice. The
      construction of the questions results from the basis of existing concepts to the 
      assessment of the end-of-life care and an analysis of all identified instruments 
      to the evaluation of inpatient hospice settings from the perspective of bereaved 
      relatives. The development of the questionnaire enclosed the formation of an item
      pool, the item choice, the critical discussion of the questions in the body of
      experts as well as a standardised and cognitive pretest beside a comprehensive
      literature research. A five-dimension questionnaire was developed that integrates
      physical, psychological, social, spiritual, and organisational aspects of the
      care at the end of life. The instrument encompasses 53 items, predominantly
      closed questions.
FAU - Lohe, Mandy
AU  - Lohe M
AD  - Martin-Luther-Universitat Halle-Wittenberg, Medizinische Fakultat, Institut fur
      Gesundheits- und Pflegewissenschaft. mandy.lohe@student.uni-halle.de
FAU - Zimmermann, Manja
AU  - Zimmermann M
FAU - Luderer, Christiane
AU  - Luderer C
FAU - Sadowski, Katharina
AU  - Sadowski K
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Die Entwicklung eines Instruments zur "Evaluation stationarer Hospize aus der
      Perspektive hinterbliebener Angehoriger" (EHPA).
PL  - Switzerland
TA  - Pflege
JT  - Pflege
JID - 8907069
MH  - Caregivers/*psychology
MH  - *Consumer Behavior
MH  - Germany
MH  - Hospice Care/*standards
MH  - Humans
MH  - Quality Assurance, Health Care/*standards
MH  - *Surveys and Questionnaires
EDAT- 2011/06/04 06:00
MHDA- 2011/09/14 06:00
CRDT- 2011/06/04 06:00
PHST- 2011/06/04 06:00 [entrez]
PHST- 2011/06/04 06:00 [pubmed]
PHST- 2011/09/14 06:00 [medline]
AID - 10.1024/1012-5302/a000118 [doi]
PST - ppublish
SO  - Pflege. 2011 Jun;24(3):171-81. doi: 10.1024/1012-5302/a000118.


PMID- 21636928
OWN - NLM
STAT- MEDLINE
DCOM- 20110928
LR  - 20161125
IS  - 0974-5181 (Electronic)
IS  - 0971-9784 (Linking)
VI  - 14
IP  - 2
DP  - 2011 May-Aug
TI  - Real-time three-dimensional echocardiographic assessment of mitral valve: Is it
      really superior to 2D transesophageal echocardiography?
PG  - 91-6
LID - 10.4103/0971-9784.81562 [doi]
AB  - Aim of our study was to investigate the feasibility of use and possible
      additional value of real-time 3D transesophageal echocardiography (RT-3D-TEE)
      compared to conventional 2D-TEE in patients undergoing elective mitral valve
      repair. After ethical committee approval, patients were included in this
      prospective study. After induction of anesthesia, a comprehensive 2D-TEE
      examination was performed, followed with RT-3D-TEE. The intraoperative surgical
      finding was used as the gold standard for segmental analysis. Only such segments 
      which were surgically corrected either by resection or insertion of artificial
      chords were judged pathologic. A total of 50 patients were included in this
      study; usable data were available from 42 of these patients . Based on the
      Carpentier classification, the pathology found was type I in 2 (5%) patients,
      type II in 39 (93%) patients and type IIIb in 1 (2%) patient. We found that 3D
      imaging of complex mitral disease involving multiple segments, when compared to
      2D-TEE did not show any statistically significant difference.RT-3D-TEE did not
      show any major advantage when compared to conventional 2D-TEE for assessing
      mitral valve pathology, although further study in a larger population is required
      to establish the validity of this study.
FAU - Mukherjee, Chirojit
AU  - Mukherjee C
AD  - Department of Anaesthesiology and Intensive Care Medicine II, Heart Center
      Leipzig, University of Leipzig, Leipzig, Germany.
FAU - Tschernich, Heinz
AU  - Tschernich H
FAU - Kaisers, Udo X
AU  - Kaisers UX
FAU - Eibel, Sarah
AU  - Eibel S
FAU - Seeburger, Joerg
AU  - Seeburger J
FAU - Ender, Joerg
AU  - Ender J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - India
TA  - Ann Card Anaesth
JT  - Annals of cardiac anaesthesia
JID - 9815987
SB  - IM
MH  - Computer Systems
MH  - Echocardiography/*methods
MH  - Echocardiography, Three-Dimensional/*methods
MH  - Echocardiography, Transesophageal/*methods
MH  - Female
MH  - Heart Valve Prosthesis Implantation/methods
MH  - Humans
MH  - Male
MH  - Minimally Invasive Surgical Procedures
MH  - Mitral Valve/*diagnostic imaging/surgery
MH  - Mitral Valve Insufficiency/physiopathology/surgery
MH  - Mitral Valve Prolapse/diagnostic imaging/surgery
MH  - Prospective Studies
EDAT- 2011/06/04 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/06/04 06:00
PHST- 2011/06/04 06:00 [entrez]
PHST- 2011/06/04 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - AnnCardAnaesth_2011_14_2_91_81562 [pii]
AID - 10.4103/0971-9784.81562 [doi]
PST - ppublish
SO  - Ann Card Anaesth. 2011 May-Aug;14(2):91-6. doi: 10.4103/0971-9784.81562.


PMID- 21636868
OWN - NLM
STAT- MEDLINE
DCOM- 20110929
LR  - 20161020
IS  - 1024-2708 (Print)
IS  - 1024-2708 (Linking)
VI  - 17
IP  - 3
DP  - 2011 Jun
TI  - Learning needs in a medical curriculum in Hong Kong.
PG  - 202-7
AB  - OBJECTIVE: To survey medical graduates from the University of Hong Kong on how
      well they perceived their learning needs had been fulfilled by the old (before
      1997) and the new (after 1997) curricula. DESIGN: Retrospective questionnaire
      survey. SETTING: The University of Hong Kong, Hong Kong. PARTICIPANTS: Medical
      graduates from the University of Hong Kong who graduated between 1997 and 2006
      were invited to complete a questionnaire online or in paper form; 1997-2001
      graduates were trained under the old curriculum, and 2002-2006 graduates under
      the new curriculum. RESULTS: The response rate was 23%. The survey showed that
      the graduates of both curricula felt that research skills, population health, and
      ophthalmology were not emphasised enough in the medical programme. In addition,
      some graduates of the old curriculum mentioned interpersonal skills, ethics and
      professionalism, and language skills, which were pinpointed in the curriculum
      reform in 1997. Some graduates of the new curriculum mentioned anatomy,
      microbiology, and diagnostic radiology. Graduates of both the old and the new
      curricula perceived the same top five areas as being lacking in their respective 
      curricula, in relationship to their clinical career and personal growth, namely: 
      business administration, law, professional English, life coaching, and
      humanities. A small percentage of graduates also took courses in these areas
      after graduation. CONCLUSIONS: The survey showed that the curriculum reform in
      1997 at the University of Hong Kong had correctly pinpointed some of the learning
      needs. The survey also identified educational needs in the existing curriculum
      that need to be dealt with in the forthcoming curriculum reform in 2012.
FAU - Chan, L K
AU  - Chan LK
AD  - Institute of Medical and Health Sciences Education, Department of Anatomy, LKS
      Faculty of Medicine, The University of Hong Kong, Hong Kong. lapki@hku.hk
FAU - Ip, Mary S M
AU  - Ip MS
FAU - Patil, N G
AU  - Patil NG
FAU - Prosser, M
AU  - Prosser M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Hong Kong Med J
JT  - Hong Kong medical journal = Xianggang yi xue za zhi
JID - 9512509
SB  - IM
MH  - *Curriculum
MH  - Education, Medical/*methods/standards
MH  - Hong Kong
MH  - Humans
MH  - Retrospective Studies
MH  - Students, Medical/*statistics & numerical data
MH  - Surveys and Questionnaires
EDAT- 2011/06/04 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/06/04 06:00
PHST- 2011/06/04 06:00 [entrez]
PHST- 2011/06/04 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
PST - ppublish
SO  - Hong Kong Med J. 2011 Jun;17(3):202-7.


PMID- 21636609
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20191210
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 8
DP  - 2011 Aug
TI  - Ethical evaluation of the website-based promotion and advertisements for in vitro
      fertilisation services in Turkey.
PG  - 510-1
LID - 10.1136/jme.2010.041996 [doi]
FAU - Karatas, M
AU  - Karatas M
AD  - Department of History of Medicine and Ethics, Faculty of Medicine, Inonu
      University, Malatya, Turkey. drkaratas@hotmail.com
FAU - Sehiralti, M
AU  - Sehiralti M
FAU - Gorkey, S
AU  - Gorkey S
FAU - Guven, T
AU  - Guven T
LA  - eng
PT  - Journal Article
DEP - 20110602
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Advertising/*ethics/*methods
MH  - Ethical Review
MH  - Evaluation Studies as Topic
MH  - *Fertilization in Vitro
MH  - Humans
MH  - Internet/*statistics & numerical data
MH  - Turkey
EDAT- 2011/06/04 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/06/04 06:00
PHST- 2011/06/04 06:00 [entrez]
PHST- 2011/06/04 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - jme.2010.041996 [pii]
AID - 10.1136/jme.2010.041996 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Aug;37(8):510-1. doi: 10.1136/jme.2010.041996. Epub 2011 Jun
      2.


PMID- 21636608
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20110720
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 8
DP  - 2011 Aug
TI  - Assessment of children's capacity to consent for research: a descriptive
      qualitative study of researchers' practices.
PG  - 504-9
LID - 10.1136/jme.2010.040097 [doi]
AB  - BACKGROUND: In Canadian jurisdictions without specific legislation pertaining to 
      research consent, the onus is placed on researchers to determine whether a child 
      is capable of independently consenting to participate in a research study.
      Little, however, is known about how child health researchers are approaching
      consent and capacity assessment in practice. The aim of this study was to explore
      and describe researchers' current practices. METHODS: The study used a
      qualitative descriptive design consisting of 14 face-to-face interviews with
      child health researchers and research assistants in Southern Ontario. Transcribed
      interviews were analysed for common themes. RESULTS: Procedures for assessing
      capacity varied considerably from the use of age cutoffs to in-depth engagement
      with each child. Three key issues emerged from the accounts: (1) requirements
      that consent be provided by a single person thwarted researchers' abilities to
      support family decision-making; (2) little practical distinction was made between
      assessing if a child was capable, versus determining if study information had
      been adequately explained by the researcher; and (3) participants' perceived that
      review boards' requirements may conflict with what they considered ethical
      consent practices. CONCLUSION: The results suggest that researchers' consent and 
      capacity knowledge and skills vary considerably. Perceived discrepancies between 
      ethical practice and ethics boards' requirements suggest the need for dialogue,
      education and possibly ethics board reforms. Furthermore we propose, where
      appropriate, a 'family decision-making' model that allows parents and their
      children to consent together, thereby shifting the focus from separate assent and
      consent procedures to approaches that appropriately engage the child and family.
FAU - Gibson, Barbara E
AU  - Gibson BE
AD  - Department of Physical Therapy, University of Toronto, 160-500 University Avenue,
      Toronto, ON Canada. barbara.gibson@utoronto.ca
FAU - Stasiulis, Elaine
AU  - Stasiulis E
FAU - Gutfreund, Shawna
AU  - Gutfreund S
FAU - McDonald, Maria
AU  - McDonald M
FAU - Dade, Lauren
AU  - Dade L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110602
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Child
MH  - Child Welfare
MH  - Comprehension
MH  - *Decision Making
MH  - Harm Reduction
MH  - Humans
MH  - Information Dissemination/methods
MH  - Informed Consent By Minors/*ethics/legislation & jurisprudence
MH  - Parent-Child Relations
MH  - Personal Autonomy
MH  - Qualitative Research
EDAT- 2011/06/04 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/06/04 06:00
PHST- 2011/06/04 06:00 [entrez]
PHST- 2011/06/04 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - jme.2010.040097 [pii]
AID - 10.1136/jme.2010.040097 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Aug;37(8):504-9. doi: 10.1136/jme.2010.040097. Epub 2011 Jun
      2.


PMID- 21636607
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20151119
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 8
DP  - 2011 Aug
TI  - Can we accredit hospital ethics? A tentative proposal.
PG  - 493-7
LID - 10.1136/jme.2010.038836 [doi]
AB  - OBJECTIVES: The objective of this research was to develop ethics accreditation
      standards for hospitals. RESEARCH DESIGN: Our research methods included a
      literature review, an expert focus group, the Delphi technique and a hospital
      survey. The entire process was separated into two stages: (1) the development of 
      a draft of hospital ethics accreditation standards; and (2) conducting a
      nationwide hospital survey of the proposed standards. RESULTS: This study
      produced a tentative draft of hospital ethics accreditation standards comprised
      of six chapters and 62 standards based on the expert focus group and Delphi
      technique. The six chapters are: Medical ethics policies, regulations and
      leadership; The establishment and operation of a medical ethics committee; The
      establishment and operation of research-related ethics committees; Medical ethics
      education; Organisational ethical climate; and Respect for patients' rights and
      establishment of good hospital-patient relationships. The hospital survey
      indicated that the concept of an organisational ethical climate was new to most
      hospital managers, most hospitals disliked the idea of having a separate hospital
      ethics accreditation system, and small hospitals were concerned about their
      ability to comply with all of the standards. CONCLUSIONS: Regardless of whether
      hospital ethics accreditation can be a stand-alone accreditation or just part of 
      existing hospital accreditation programmes, we hope this draft can serve as a
      good reference for future endeavours by hospital accreditation authorities.
FAU - Wu, Min-Hua
AU  - Wu MH
AD  - Food and Drug Administration, Department of Health, Taipei, Taiwan.
FAU - Liao, Chih-Hsien
AU  - Liao CH
FAU - Chiu, Wen-Ta
AU  - Chiu WT
FAU - Lin, Ching-Ying
AU  - Lin CY
FAU - Yang, Che-Ming
AU  - Yang CM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110602
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Accreditation/*methods
MH  - Delphi Technique
MH  - Ethics Committees, Clinical/*standards
MH  - Ethics Committees, Research
MH  - *Ethics, Institutional
MH  - Expert Testimony
MH  - Focus Groups
MH  - Health Policy/legislation & jurisprudence
MH  - Humans
MH  - Leadership
MH  - Patient Rights/ethics
MH  - Surveys and Questionnaires
EDAT- 2011/06/04 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/06/04 06:00
PHST- 2011/06/04 06:00 [entrez]
PHST- 2011/06/04 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - jme.2010.038836 [pii]
AID - 10.1136/jme.2010.038836 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Aug;37(8):493-7. doi: 10.1136/jme.2010.038836. Epub 2011 Jun
      2.


PMID- 21636081
OWN - NLM
STAT- MEDLINE
DCOM- 20120321
LR  - 20111017
IS  - 1973-8102 (Electronic)
IS  - 0010-9452 (Linking)
VI  - 47
IP  - 10
DP  - 2011 Nov-Dec
TI  - Some ethical issues in brain imaging.
PG  - 1272-4
LID - 10.1016/j.cortex.2011.05.001 [doi]
FAU - Macdonald, Murdo
AU  - Macdonald M
AD  - Church of Scotland, Society, Religion and Technology Project, Edinburgh, UK.
      mmacdonald@cofscotland.org.uk
LA  - eng
PT  - Journal Article
DEP - 20110510
PL  - Italy
TA  - Cortex
JT  - Cortex; a journal devoted to the study of the nervous system and behavior
JID - 0100725
SB  - IM
MH  - *Bioethical Issues
MH  - Brain/physiology
MH  - Criminal Law
MH  - Functional Neuroimaging/*ethics
MH  - Humans
MH  - Jurisprudence
MH  - Neurosciences/*ethics
MH  - *Privacy
EDAT- 2011/06/04 06:00
MHDA- 2012/03/22 06:00
CRDT- 2011/06/04 06:00
PHST- 2011/02/21 00:00 [received]
PHST- 2011/05/02 00:00 [accepted]
PHST- 2011/06/04 06:00 [entrez]
PHST- 2011/06/04 06:00 [pubmed]
PHST- 2012/03/22 06:00 [medline]
AID - S0010-9452(11)00144-4 [pii]
AID - 10.1016/j.cortex.2011.05.001 [doi]
PST - ppublish
SO  - Cortex. 2011 Nov-Dec;47(10):1272-4. doi: 10.1016/j.cortex.2011.05.001. Epub 2011 
      May 10.


PMID- 21636054
OWN - NLM
STAT- MEDLINE
DCOM- 20120302
LR  - 20220408
IS  - 1558-349X (Electronic)
IS  - 1546-1440 (Linking)
VI  - 8
IP  - 6
DP  - 2011 Jun
TI  - Informing patients about risks and benefits of radiology examinations: a review
      article.
PG  - 402-8
LID - 10.1016/j.jacr.2010.09.007 [doi]
AB  - Communicating the risks, benefits, and alternatives to a planned medical
      intervention is integral to high-quality patient care. When effective, such
      communication promotes patient autonomy, alleviates unfounded patient
      apprehension, and mitigates medicolegal liability. The topic of medical radiation
      adds to the usual challenges of effective medical communication some special
      challenges of its own. Among these is a lack of understanding by the general
      population and health professionals of the benefits and risks of medical
      radiation, which is compounded by unfamiliar terminology and units of measure.
      This is further complicated by the fact that many patients have poor
      comprehension of risk data in general. In this article, the authors present a
      case, review the ethical basis and legal history of informed consent, and explore
      the current initiatives, available resources, and further opportunities related
      to this challenging topic.
CI  - Copyright (c) 2011. Published by Elsevier Inc.
FAU - Cardinal, Jeremy S
AU  - Cardinal JS
AD  - Department of Radiology, Indiana University School of Medicine, Indianapolis, IN,
      USA.
FAU - Gunderman, Richard B
AU  - Gunderman RB
FAU - Tarver, Robert D
AU  - Tarver RD
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Am Coll Radiol
JT  - Journal of the American College of Radiology : JACR
JID - 101190326
SB  - IM
CIN - J Am Coll Radiol. 2011 Nov;8(11):742-3. PMID: 22051453
MH  - *Communication
MH  - Humans
MH  - *Informed Consent
MH  - *Patient Acceptance of Health Care
MH  - Patient Education as Topic/*methods
MH  - *Physician-Patient Relations
MH  - Radiology/*education
MH  - Risk Assessment/methods
MH  - United States
EDAT- 2011/06/04 06:00
MHDA- 2012/03/03 06:00
CRDT- 2011/06/04 06:00
PHST- 2010/08/11 00:00 [received]
PHST- 2010/09/13 00:00 [accepted]
PHST- 2011/06/04 06:00 [entrez]
PHST- 2011/06/04 06:00 [pubmed]
PHST- 2012/03/03 06:00 [medline]
AID - S1546-1440(10)00519-3 [pii]
AID - 10.1016/j.jacr.2010.09.007 [doi]
PST - ppublish
SO  - J Am Coll Radiol. 2011 Jun;8(6):402-8. doi: 10.1016/j.jacr.2010.09.007.


PMID- 21635769
OWN - NLM
STAT- MEDLINE
DCOM- 20110907
LR  - 20211020
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 12
DP  - 2011 Jun 2
TI  - Untapped ethical resources for neurodegeneration research.
PG  - 9
LID - 10.1186/1472-6939-12-9 [doi]
AB  - BACKGROUND: The research community has a mandate to discover effective treatments
      for neurodegenerative disorders. The ethics landscape surrounding this mandate is
      in a constant state of flux, and ongoing challenges place ever greater demands on
      investigators to be accountable to the public and to answer questions about the
      implications of their work for health care, society, and policy. METHODS: We
      surveyed US-based investigators involved in neurodegenerative diseases research
      about how they value ethics-related issues, what motivates them to give
      consideration to those issues, and the barriers to doing so. Using the NIH CRISP 
      database we identified 1,034 researchers with relevant, active grants and invited
      them to complete an online questionnaire. We received 193 responses. We used
      exploratory factor analysis to transform individual survey questions into a
      smaller set of factors, and linear regression to understand the effect of key
      variables of interest on the factor scores. RESULTS: Ethics-related issues
      clustered into two groups: research ethics and external influences. Heads of
      research groups viewed issues of research ethics to be more important than the
      other respondents. Concern about external influences was related to overall
      interest in ethics. Motivators clustered into five groups: ensuring public
      understanding, external forces, requirements, values, and press and public. Heads
      of research groups were more motivated to ensure public understanding of research
      than the other respondents. Barriers clustered into four groups: lack of
      resources, administrative burden, relevance to the research, and lack of
      interest. Perceived lack of ethics resources was a particular barrier for
      investigators working in drug discovery. CONCLUSIONS: The data suggest that
      senior level neuroscientists working in the field of neurodegeneration (ND), and 
      drug discovery specifically, are motivated to consider ethics issues related to
      their work, but the perceived lack of ethics resources thwarts their efforts.
      With bioethics centres at more than 50% of the institutions at which these
      respondents reside, the neuroscience and bioethics communities appear to be
      disconnected. Dedicated ethical, legal and social implications (ELSI) programs,
      such as those fully integrated into genetics and regenerative medicine, provide
      models for achieving meaningful partnerships not yet adequately realized for
      scholars and trainees interested in drug discovery for ND.
FAU - Robillard, Julie M
AU  - Robillard JM
AD  - National Core for Neuroethics, Division of Neurology, University of British
      Columbia, Vancouver, BC, Canada.
FAU - Federico, Carole A
AU  - Federico CA
FAU - Tairyan, Kate
AU  - Tairyan K
FAU - Ivinson, Adrian J
AU  - Ivinson AJ
FAU - Illes, Judy
AU  - Illes J
LA  - eng
GR  - CIHR 85117/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110602
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Adult
MH  - Confounding Factors, Epidemiologic
MH  - *Drug Discovery/ethics
MH  - *Ethics, Research
MH  - Evidence-Based Medicine
MH  - Factor Analysis, Statistical
MH  - Female
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - *Neurodegenerative Diseases
MH  - Research/economics/*trends
MH  - Research Design
MH  - Research Personnel
MH  - Surveys and Questionnaires
MH  - United States
PMC - PMC3127846
EDAT- 2011/06/04 06:00
MHDA- 2011/09/08 06:00
CRDT- 2011/06/04 06:00
PHST- 2011/01/05 00:00 [received]
PHST- 2011/06/02 00:00 [accepted]
PHST- 2011/06/04 06:00 [entrez]
PHST- 2011/06/04 06:00 [pubmed]
PHST- 2011/09/08 06:00 [medline]
AID - 1472-6939-12-9 [pii]
AID - 10.1186/1472-6939-12-9 [doi]
PST - epublish
SO  - BMC Med Ethics. 2011 Jun 2;12:9. doi: 10.1186/1472-6939-12-9.


PMID- 21635681
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20110603
IS  - 1939-3938 (Electronic)
IS  - 1556-3693 (Linking)
VI  - 7
IP  - 2
DP  - 2011 Jun
TI  - Criminalistics and the forensic nursing process.
PG  - 97-104
LID - 10.1111/j.1939-3938.2011.01105.x [doi]
AB  - Students learn science by actually performing science activities. The 12
      laboratories described in this article assist students in applying the
      fundamental techniques germane to the field of forensic science to "solve"
      contrived cases and present "evidence" in a mock trial. Moreover, students are
      also confronted with some of the legal and ethical issues concerning the
      validity, reliability, and application of some forensic techniques. The
      pedagogical design of the laboratory course provides a rich, challenging, and
      interdisciplinary academic experience intended to augment and compliment the
      didactic forensic lecture portion of the course. This laboratory course was
      designed to engender, embody, and articulate one of the University's directive
      goals to support interdisciplinary teaching, research, and programming. Because
      we developed the laboratories on minimal funds, we demonstrated that it could be 
      cost-effective. And thus, we recommend a laboratory science course be included as
      part of the curriculum of all forensic nursing students and practitioners.
CI  - (c) 2011 International Association of Forensic Nurses.
FAU - Burgess, Ann Wolbert
AU  - Burgess AW
AD  - Professor, Psychiatric Nursing, William F. Connell School of Nursing, Boston
      College, Chestnut Hill, MA 02467, USA. burges@bc.edu
FAU - Piatelli, Michael J
AU  - Piatelli MJ
FAU - Pasqualone, Georgia
AU  - Pasqualone G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Forensic Nurs
JT  - Journal of forensic nursing
JID - 101234500
SB  - IM
MH  - Boston
MH  - *Clinical Laboratory Techniques
MH  - Criminology/*education
MH  - Equipment and Supplies/economics
MH  - *Expert Testimony
MH  - Forensic Nursing/*education
MH  - Humans
MH  - Program Development
MH  - Teaching/methods
EDAT- 2011/06/04 06:00
MHDA- 2011/10/25 06:00
CRDT- 2011/06/04 06:00
PHST- 2011/06/04 06:00 [entrez]
PHST- 2011/06/04 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
AID - 10.1111/j.1939-3938.2011.01105.x [doi]
PST - ppublish
SO  - J Forensic Nurs. 2011 Jun;7(2):97-104. doi: 10.1111/j.1939-3938.2011.01105.x.


PMID- 21635587
OWN - NLM
STAT- MEDLINE
DCOM- 20120723
LR  - 20220317
IS  - 1365-2702 (Electronic)
IS  - 0962-1067 (Linking)
VI  - 21
IP  - 7-8
DP  - 2012 Apr
TI  - Forecasting the ward climate: a study from a dementia care unit.
PG  - 1136-114
LID - 10.1111/j.1365-2702.2011.03720.x [doi]
AB  - AIMS AND OBJECTIVES: This article present findings from a study aiming to explore
      the psychosocial climate and its influence on the well-being of people with
      dementia in a psycho-geriatric hospital unit. BACKGROUND: Environmental influence
      in dementia is well explored in relation to the physical environment; however,
      few studies have explored the psychosocial environment and its influence on
      well-being. DESIGN: The study had a grounded theory design. METHODS: Participant 
      observations were conducted in a psycho-geriatric ward for assessment and
      treatment of people with dementia in Sweden (n = 36 hours). Data were collected
      and analysed in a dialectical fashion using the principles of grounded theory
      methodology. RESULTS: The basic social process that best accounted for the
      variation in the psychosocial climate and well-being of patients at the unit was 
      'staff presence or absence', conceptualised as the core category. Three
      categories emerged in relation to the core category; 'sharing place and moment', 
      'sharing place but not moment' and 'sharing neither place nor moment'.
      CONCLUSIONS: Staff were catalysts for the psychosocial climate and when being
      present and engaged they could create a climate interpreted as at-homeness which 
      supported patient well-being. When being absent, the climate quickly became
      anxious and this facilitated patient ill-being. To provide quality care for
      people with dementia staff need to be aware of their role in setting the
      emotional tone of the psychosocial climate and also that this emotional tone
      significantly influences patient well-being. RELEVANCE TO CLINICAL PRACTICE: The 
      findings are clinically relevant and can be operationalised and applied in
      clinical practice. Awareness of the intimate connection between staff presence
      and absence, the psychosocial climate and patient well-being highlights an
      ethical responsibility to question: routines that promote staff absence; a
      culture of merely 'doing for'; and nursing tasks which involve a minimum of
      staff-patient interaction. The findings have implications for managers as well as
      for clinical staff.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Edvardsson, David
AU  - Edvardsson D
AD  - Division of Nursing and Midwifery, La Trobe University, Bundoora, Victoria,
      Australia and Department of Nursing, Umea University, Umea, Sweden.
      d.edvardsson@latrobe.edu.au
FAU - Sandman, Per-Olof
AU  - Sandman PO
FAU - Rasmussen, Birgit
AU  - Rasmussen B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110602
PL  - England
TA  - J Clin Nurs
JT  - Journal of clinical nursing
JID - 9207302
MH  - Aged
MH  - Alzheimer Disease/diagnosis/nursing
MH  - *Attitude of Health Personnel
MH  - Dementia/diagnosis/*nursing
MH  - Environment
MH  - Female
MH  - Follow-Up Studies
MH  - Forecasting
MH  - Humans
MH  - Male
MH  - Morals
MH  - Needs Assessment
MH  - Nurse-Patient Relations
MH  - Nursing Staff, Hospital/psychology
MH  - Psychiatric Nursing/*trends
MH  - Psychology
MH  - Qualitative Research
MH  - Quality Control
MH  - Sweden
MH  - Treatment Outcome
EDAT- 2011/06/04 06:00
MHDA- 2012/07/24 06:00
CRDT- 2011/06/04 06:00
PHST- 2011/06/04 06:00 [entrez]
PHST- 2011/06/04 06:00 [pubmed]
PHST- 2012/07/24 06:00 [medline]
AID - 10.1111/j.1365-2702.2011.03720.x [doi]
PST - ppublish
SO  - J Clin Nurs. 2012 Apr;21(7-8):1136-114. doi: 10.1111/j.1365-2702.2011.03720.x.
      Epub 2011 Jun 2.


PMID- 21635364
OWN - NLM
STAT- MEDLINE
DCOM- 20120103
LR  - 20181201
IS  - 1651-2227 (Electronic)
IS  - 0803-5253 (Linking)
VI  - 100
IP  - 9
DP  - 2011 Sep
TI  - Ethical reflections on organ donation from children.
PG  - 1172-4
LID - 10.1111/j.1651-2227.2011.02373.x [doi]
FAU - Engstrom, Ingemar
AU  - Engstrom I
AD  - Psychiatric Research Centre, School of Health and Medical Sciences, Orebro
      University, Orebro, Sweden. ingemar.engstrom@oru.se
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20110701
PL  - Norway
TA  - Acta Paediatr
JT  - Acta paediatrica (Oslo, Norway : 1992)
JID - 9205968
SB  - IM
CON - Acta Paediatr. 2011 Sep;100(9):1175-9. PMID: 21668497
MH  - *Culture
MH  - *Decision Making
MH  - *Ethics, Medical
MH  - Humans
MH  - Tissue and Organ Procurement/*ethics
EDAT- 2011/06/04 06:00
MHDA- 2012/01/04 06:00
CRDT- 2011/06/04 06:00
PHST- 2011/06/04 06:00 [entrez]
PHST- 2011/06/04 06:00 [pubmed]
PHST- 2012/01/04 06:00 [medline]
AID - 10.1111/j.1651-2227.2011.02373.x [doi]
PST - ppublish
SO  - Acta Paediatr. 2011 Sep;100(9):1172-4. doi: 10.1111/j.1651-2227.2011.02373.x.
      Epub 2011 Jul 1.


PMID- 21634109
OWN - NLM
STAT- MEDLINE
DCOM- 20110622
LR  - 20191112
IS  - 0354-950X (Print)
IS  - 0354-950X (Linking)
VI  - 58
IP  - 1
DP  - 2011
TI  - [Legal aspects of medical errors].
PG  - 107-11
AB  - Healing people and medical care are together highly organized technological
      system with significant expert, ethical and legal regulative. Taking medical care
      is very sensitive area and it interfears deep into one's integrity, so the law is
      necessary in this area as a regulator. The aim of work is to show medical errors 
      from legal aspects and clinical practice. Errors, negligent conduct during the
      medical treatment and bad results of medical treatment are categories that can
      easily be switched or can sublime themselves into the same thing. That is why
      correct differentiation of medical errors and viewing every way of medical errors
      appearance is necessary.
FAU - Vucetic, Cedomir S
AU  - Vucetic CS
AD  - Klinika za ortopedsku hirurgiju i traumatologiju KCS, Beograd.
FAU - Vukasinovic, Zoran S
AU  - Vukasinovic ZS
FAU - Tulic, Goran Dz
AU  - Tulic GDz
FAU - Dulic, Borivoje V
AU  - Dulic BV
FAU - Dimitrijevic, K
AU  - Dimitrijevic K
FAU - Kalezic, Nevena K
AU  - Kalezic NK
LA  - srp
PT  - English Abstract
PT  - Journal Article
PL  - Serbia
TA  - Acta Chir Iugosl
JT  - Acta chirurgica Iugoslavica
JID - 0372631
SB  - IM
MH  - Humans
MH  - Medical Errors/*legislation & jurisprudence
MH  - Serbia
EDAT- 2011/06/04 06:00
MHDA- 2011/06/23 06:00
CRDT- 2011/06/04 06:00
PHST- 2011/06/04 06:00 [entrez]
PHST- 2011/06/04 06:00 [pubmed]
PHST- 2011/06/23 06:00 [medline]
AID - 10.2298/aci1101107v [doi]
PST - ppublish
SO  - Acta Chir Iugosl. 2011;58(1):107-11. doi: 10.2298/aci1101107v.


PMID- 21633864
OWN - NLM
STAT- MEDLINE
DCOM- 20131122
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 18
IP  - 4
DP  - 2012 Dec
TI  - Design, development, and evaluation of a second generation interactive Simulator 
      for Engineering Ethics Education (SEEE2).
PG  - 689-97
LID - 10.1007/s11948-011-9284-0 [doi]
AB  - This paper describes a second generation Simulator for Engineering Ethics
      Education. Details describing the first generation activities of this overall
      effort are published in Chung and Alfred (Sci Eng Ethics 15:189-199, 2009). The
      second generation research effort represents a major development in the
      interactive simulator educational approach. As with the first generation effort, 
      the simulator places students in first person perspective scenarios involving
      different types of ethical situations. Students must still gather data, assess
      the situation, and make decisions. The approach still requires students to
      develop their own ability to identify and respond to ethical engineering
      situations. However, were as, the generation one effort involved the use of a
      dogmatic model based on National Society of Professional Engineers' Code of
      Ethics, the new generation two model is based on a mathematical model of the
      actual experiences of engineers involved in ethical situations. This approach
      also allows the use of feedback in the form of decision effectiveness and
      professional career impact. Statistical comparisons indicate a 59 percent
      increase in overall knowledge and a 19 percent improvement in teaching
      effectiveness over an Internet Engineering Ethics resource based approach.
FAU - Alfred, Michael
AU  - Alfred M
AD  - Department of Industrial Engineering, University of Houston, Eng. Bldg. 2, E215, 
      Houston, TX 77204-4812, USA.
FAU - Chung, Christopher A
AU  - Chung CA
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110602
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Codes of Ethics
MH  - *Decision Making
MH  - Engineering/education/*ethics
MH  - Ethics, Professional/*education
MH  - Humans
MH  - Internet
MH  - Models, Psychological
MH  - *Problem-Based Learning
MH  - *Professional Competence
MH  - Teaching/*methods/standards
EDAT- 2011/06/03 06:00
MHDA- 2013/12/16 06:00
CRDT- 2011/06/03 06:00
PHST- 2010/12/30 00:00 [received]
PHST- 2011/05/15 00:00 [accepted]
PHST- 2011/06/03 06:00 [entrez]
PHST- 2011/06/03 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1007/s11948-011-9284-0 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2012 Dec;18(4):689-97. doi: 10.1007/s11948-011-9284-0. Epub 2011 
      Jun 2.


PMID- 21633672
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1936-5233 (Electronic)
IS  - 1936-5233 (Linking)
VI  - 4
IP  - 3
DP  - 2011 Jun
TI  - Feasibility and safety of silicone rubber contrast-enhanced microcomputed
      tomography in evaluating the angioarchitecture of prostatectomy specimens.
PG  - 173-7
AB  - This ethics committee-approved pilot study was carried out with informed consent.
      A protocol was developed to assess the feasibility of in vitro Microfil injection
      of prostate cancer specimens followed by analysis with micro-computed tomography 
      (microCT) to characterize the functional vascularity of prostatic tissue and
      evaluate its safety with respect to the preservation of a specimen for pathologic
      examination. The visible prostatic arteries of two surgically resected prostates 
      frompatients with known prostate cancer (PCa) were injected with MicrofilMV-122
      contrast medium immediately after removal. The specimens were scanned using
      microCT and were qualitatively examined using three-dimensional analysis software
      (MicroView; GE Healthcare Biosciences). The Microfil perfusion in the two samples
      was sufficient to view the functional vascularity arising from a major prostatic 
      artery, up to a resolution of 17.626 microm without any indication of adverse
      effects due to Microfil injection. Malignant prostatic regions showed a greater
      vascular density on histology but decreased vascular perfusion compared with
      benign prostatic regions. The use of microCT on Microfil-injected prostates seems
      to be a feasible and specimen-preserving method for visualizing the
      three-dimensional vessel patterns present in resected human prostates.
FAU - Yeung, Alex K
AU  - Yeung AK
AD  - Department of Medical Imaging, Toronto General Hospital, Toronto, Ontario,
      Canada.
FAU - Atri, Mostafa
AU  - Atri M
FAU - Sugar, Linda
AU  - Sugar L
FAU - Klotz, Laurence
AU  - Klotz L
LA  - eng
PT  - Journal Article
DEP - 20110601
PL  - United States
TA  - Transl Oncol
JT  - Translational oncology
JID - 101472619
PMC - PMC3104697
EDAT- 2011/06/03 06:00
MHDA- 2011/06/03 06:01
CRDT- 2011/06/03 06:00
PHST- 2010/12/31 00:00 [received]
PHST- 2011/03/24 00:00 [revised]
PHST- 2011/03/24 00:00 [accepted]
PHST- 2011/06/03 06:00 [entrez]
PHST- 2011/06/03 06:00 [pubmed]
PHST- 2011/06/03 06:01 [medline]
AID - 10.1593/tlo.10304 [doi]
PST - ppublish
SO  - Transl Oncol. 2011 Jun;4(3):173-7. doi: 10.1593/tlo.10304. Epub 2011 Jun 1.


PMID- 21633619
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1998-3735 (Electronic)
IS  - 0973-1075 (Linking)
VI  - 17
IP  - 1
DP  - 2011 Jan
TI  - The Attitudes of Indian Palliative-care Nurses and Physicians to Pain Control and
      Palliative Sedation.
PG  - 33-41
LID - 10.4103/0973-1075.78447 [doi]
AB  - AIM: We wanted to assess Indian palliative-care nurses and physicians' attitudes 
      toward pain control and palliative sedation. MATERIALS AND METHODS: From May to
      September 2008, we interviewed 14 physicians and 13 nurses working in different
      palliative-care programs in New Delhi, using a semi-structured questionnaire, and
      following grounded-theory methodology (Glaser and Strauss). RESULTS: The
      interviewees did not consider administration of painkillers in large doses an
      ethical problem, provided the pain killers are properly titrated. Mild palliative
      sedation was considered acceptable. The interviewees disagreed whether palliative
      sedation can also be deep and continuous. Arguments mentioned against deep
      continuous palliative sedation were the conviction that it may cause unacceptable
      side effects, and impedes basic daily activities and social contacts. A few
      interviewees said that palliative sedation may hasten death. CONCLUSION: Due to
      fears and doubts regarding deep continuous palliative sedation, it may sometimes 
      be too easily discarded as a treatment option for refractory symptoms.
FAU - Gielen, Joris
AU  - Gielen J
AD  - Interdisciplinary Centre for the Study of Religion and World View (Catholic
      University Leuven), Sint-Michielsstraat 4 - Bus 3101, 3000 Leuven, Belgium.
FAU - Gupta, Harmala
AU  - Gupta H
FAU - Rajvanshi, Ambika
AU  - Rajvanshi A
FAU - Bhatnagar, Sushma
AU  - Bhatnagar S
FAU - Mishra, Seema
AU  - Mishra S
FAU - Chaturvedi, Arvind K
AU  - Chaturvedi AK
FAU - den Branden, Stef Van
AU  - den Branden SV
FAU - Broeckaert, Bert
AU  - Broeckaert B
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Indian J Palliat Care
JT  - Indian journal of palliative care
JID - 101261221
PMC - PMC3098541
OTO - NOTNLM
OT  - Attitudes
OT  - India
OT  - Nurses
OT  - Pain control
OT  - Palliative care
OT  - Palliative sedation
OT  - Physicians
EDAT- 2011/06/03 06:00
MHDA- 2011/06/03 06:01
CRDT- 2011/06/03 06:00
PHST- 2011/06/03 06:00 [entrez]
PHST- 2011/06/03 06:00 [pubmed]
PHST- 2011/06/03 06:01 [medline]
AID - 10.4103/0973-1075.78447 [doi]
AID - IJPC-17-33 [pii]
PST - ppublish
SO  - Indian J Palliat Care. 2011 Jan;17(1):33-41. doi: 10.4103/0973-1075.78447.


PMID- 21633514
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20211020
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 6
IP  - 5
DP  - 2011
TI  - Cost-effectiveness of early treatment with first-line NNRTI-based HAART regimens 
      in the UK, 1996-2006.
PG  - e20200
LID - 10.1371/journal.pone.0020200 [doi]
AB  - AIM: Calculate time to first-line treatment failure, annual cost and
      cost-effectiveness of NNRTI versus PIboosted first-line HAART regimens in the UK,
      1996-2006. BACKGROUND: Population costs for HIV services are increasing in the UK
      and interventions need to be effective and efficient to reduce or stabilize
      costs. 2NRTIs + NNRTI regimens are cost-effective regimens for first-line HAART, 
      but these regimens have not been compared with first-line PI(boosted) regimens.
      METHODS: Times to first-line treatment failure and annual costs were calculated
      for first-line HAART regimens by CD4 count when starting HAART (2006 UK prices). 
      Cost-effectiveness of 2NRTIs+NNRTI versus 2NRTIs+PI(boosted) regimens was
      calculated for four CD4 strata. RESULTS: 55% of 5,541 people living with HIV
      (PLHIV) started HAART with CD4 count </= 200 cells/mm3, many of whom were Black
      Africans. Annual treatment cost decreased as CD4 count increased; most marked
      differences were observed between starting HAART with CD4 </= 200 cells/mm3
      compared with CD4 count >200 cells/mm3. 2NRTI+PI(boosted) and 2NRTI+NNRTI
      regimens were the most effective regimens across the four CD4 strata; 2NRTI +
      NNRTI was cost-saving or cost-effective compared with 2NRTI + PI(boosted)
      regimens. CONCLUSION: To ensure more effective and efficient provision of HIV
      services, 2NRTI+NNRTI should be started as first-line HAART regimen at CD4 counts
      </= 350 cell/mm3, unless specific contra-indications exist. This will increase
      the number of PLHIV receiving HAART and will initially increase population costs 
      of providing HIV services. However, starting PLHIV earlier on cost-effective
      regimens will maintain them in better health and use fewer health or social
      services, thereby generating fewer treatment and care costs, enabling them to
      remain socially and economically active members of society. This does raise a
      number of ethical issues, which will have to be acknowledged and addressed,
      especially in countries with limited resources.
FAU - Beck, Eduard J
AU  - Beck EJ
AD  - NPMS-HHC Coordinating and Analytic Centre, London, United Kingdom.
      becke@unaids.org
FAU - Mandalia, Sundhiya
AU  - Mandalia S
FAU - Lo, Gary
AU  - Lo G
FAU - Sharott, Peter
AU  - Sharott P
FAU - Youle, Mike
AU  - Youle M
FAU - Anderson, Jane
AU  - Anderson J
FAU - Baily, Guy
AU  - Baily G
FAU - Brettle, Ray
AU  - Brettle R
FAU - Fisher, Martin
AU  - Fisher M
FAU - Gompels, Mark
AU  - Gompels M
FAU - Kinghorn, George
AU  - Kinghorn G
FAU - Johnson, Margaret
AU  - Johnson M
FAU - McCarron, Brendan
AU  - McCarron B
FAU - Pozniak, Anton
AU  - Pozniak A
FAU - Tang, Alan
AU  - Tang A
FAU - Walsh, John
AU  - Walsh J
FAU - White, David
AU  - White D
FAU - Williams, Ian
AU  - Williams I
FAU - Gazzard, Brian
AU  - Gazzard B
CN  - NPMS-HHC Steering Group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110525
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Reverse Transcriptase Inhibitors)
SB  - IM
MH  - Adult
MH  - Algorithms
MH  - Antiretroviral Therapy, Highly Active/*methods/statistics & numerical data
MH  - CD4 Lymphocyte Count
MH  - Cost-Benefit Analysis
MH  - Female
MH  - HIV Infections/*drug therapy/*economics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Outcome Assessment, Health Care/methods/statistics & numerical data
MH  - Reverse Transcriptase Inhibitors/*therapeutic use
MH  - Survival Analysis
MH  - Time Factors
MH  - United Kingdom
PMC - PMC3102104
EDAT- 2011/06/03 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/06/03 06:00
PHST- 2010/12/13 00:00 [received]
PHST- 2011/04/27 00:00 [accepted]
PHST- 2011/06/03 06:00 [entrez]
PHST- 2011/06/03 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - 10.1371/journal.pone.0020200 [doi]
AID - PONE-D-10-06496 [pii]
PST - ppublish
SO  - PLoS One. 2011;6(5):e20200. doi: 10.1371/journal.pone.0020200. Epub 2011 May 25.


PMID- 21633051
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 260
IP  - 2
DP  - 2011 Aug
TI  - Proximal aneurysmal neck: dynamic ECG-gated CT angiography--conformational
      pulsatile changes with possible consequences for endograft sizing.
PG  - 591-8
LID - 10.1148/radiol.11101307 [doi]
AB  - PURPOSE: To assess the magnitude of variations in size of the proximal neck of
      the abdominal aortic aneurysm (AAA) in patients selected to undergo endovascular 
      abdominal aortic aneurysm repair (EVAR) and the potential effect on choice of
      endograft diameter by using 64-section dynamic electrocardiographically
      (ECG)-gated computed tomographic (CT) angiography. MATERIALS AND METHODS: A
      prospective single-center study was performed in 40 patients with AAA who
      underwent both static and dynamic ECG-gated CT angiography. The ethical conduct
      of the study was approved by the departmental review board, and all patients
      provided written informed consent. Dynamic ECG-gated data sets were acquired with
      a low-dose acquisition protocol (100 kV) by using a 0.625-mm-section collimation 
      (40 mL iomeprol [400 mg of iodine per milliliter] versus 80 mL). Pulsatility
      measurements were taken at suprarenal, juxtarenal, and infrarenal levels within
      the aneurysmal neck. Manual CT angiographic measurements were performed on
      modified axial images. On static axial images, one vascular surgeon and one
      interventional radiologist selected the diameter of the main body of the
      potential infrarenal stent-graft to implant. The diameter of the main body of the
      stent-graft selected was compared with the dynamic measurements obtained to
      calculate the potential relative oversizing performed. RESULTS: A total of 40
      patients were enrolled. Significant aortic pulsatility was demonstrated within
      the aneurysmal neck (mean variation, 9.01% +/- 4.81 [standard deviation];
      absolute change, 1.83 mm +/- 1.01; P < .05). When compared with dynamic
      measurements, the diameter of the endograft selected on the basis of static
      images would be potentially changed in 12 of 40 (30%) patients. Comparing the
      minimum or maximum diameter of the aneurysmal neck with the diameter of the
      endograft selected on the basis of static images, the relative oversizing
      performed was considered inadequate in seven of 40 (18%) patients. CONCLUSION:
      Dynamic ECG-gated CT may provide information in regard to pulsatile motion that
      could change the diameter of the endograft selected on the basis of static
      imaging measurements.
CI  - (c) RSNA, 2011.
FAU - Iezzi, Roberto
AU  - Iezzi R
AD  - Department of Bioimaging and Radiological Sciences, Institute of Radiology, A.
      Gemelli Hospital-Catholic University, Largo A. Gemelli 8, 00168 Rome, Italy.
      roberto.iezzi@rm.unicatt.it
FAU - Di Stasi, Carmine
AU  - Di Stasi C
FAU - Dattesi, Roberta
AU  - Dattesi R
FAU - Pirro, Federica
AU  - Pirro F
FAU - Nestola, Massimiliano
AU  - Nestola M
FAU - Cina, Alessandro
AU  - Cina A
FAU - Codispoti, Francesco A
AU  - Codispoti FA
FAU - Snider, Francesco
AU  - Snider F
FAU - Bonomo, Lorenzo
AU  - Bonomo L
LA  - eng
PT  - Journal Article
DEP - 20110601
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - 17E17JBP8L (iomeprol)
RN  - JR13W81H44 (Iopamidol)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Angiography/*methods
MH  - Aortic Aneurysm, Abdominal/*diagnostic imaging/surgery
MH  - Blood Vessel Prosthesis
MH  - Contrast Media
MH  - *Electrocardiography
MH  - Female
MH  - Humans
MH  - Imaging, Three-Dimensional
MH  - Iopamidol/analogs & derivatives
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Prosthesis Fitting
MH  - Pulsatile Flow
MH  - *Tomography, X-Ray Computed
EDAT- 2011/06/03 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/06/03 06:00
PHST- 2011/06/03 06:00 [entrez]
PHST- 2011/06/03 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - radiol.11101307 [pii]
AID - 10.1148/radiol.11101307 [doi]
PST - ppublish
SO  - Radiology. 2011 Aug;260(2):591-8. doi: 10.1148/radiol.11101307. Epub 2011 Jun 1.


PMID- 21632992
OWN - NLM
STAT- MEDLINE
DCOM- 20120302
LR  - 20191210
IS  - 1550-9613 (Electronic)
IS  - 0278-4297 (Linking)
VI  - 30
IP  - 6
DP  - 2011 Jun
TI  - Evaluation of a new disinfection method for ultrasound probes used for regional
      anesthesia: ultraviolet C light.
PG  - 785-8
AB  - OBJECTIVES: Ultrasound-guided regional anesthesia is commonly used for block
      placement. At present, the risk of cross contamination from probes is not well
      documented. To avoid transmission of infectious agents, several methods have been
      used for probe disinfection and protection. The aim of this study was to evaluate
      the antibacterial efficacy of a new high-level disinfection method based on
      ultraviolet C (UV-C) light under routine conditions after block placement with an
      unprotected probe. METHODS: The study was after approval by the local Ethics
      Committee. In the first part of the study, 15 ultrasound probes were exposed to a
      large inoculum of 3 bacteria. Ultraviolet C disinfection consisted of cleaning
      the probe with dry and disinfectant-impregnated paper followed by a 90-second
      UV-C disinfection cycle in a decontamination chamber. A protocol was established 
      to retrieve the probe with sterile gloves after opening the door of the chamber. 
      In the second part, 50 blocks were placed with ultrasound-guided regional
      anesthesia. The skin was first prepared with an antiseptic solution, and sterile 
      gel was applied; no covers were used to protect the probes. The blocks were then 
      disinfected with UV-C light. Bacteriologic samples were collected before and
      after the UV-C method and inoculated on chocolate agar plates. RESULTS: During
      the first part of the study, all probes were infected after inoculation (>150
      colony-forming units) but were considered sterile (<10 colony-forming units)
      after disinfection. During the second part of the study, all probes were
      considered sterile before and after disinfection. CONCLUSIONS: Ultraviolet C
      disinfection seems relevant for ultrasound-guided regional anesthesia just before
      block placement. It offers simple, fast, and effective high-level disinfection.
      Moreover, this method should obviate the use of sterile probe covers, which can
      improve echogenicity.
FAU - Bloc, Sebastien
AU  - Bloc S
AD  - Claude Galien Private Hospital, 20 Route de Boussy, 91480 Quincy-Sous-Senart,
      France. francanest@mac.com
FAU - Mercadal, Luc
AU  - Mercadal L
FAU - Garnier, Thierry
AU  - Garnier T
FAU - Komly, Bernard
AU  - Komly B
FAU - Leclerc, Pascal
AU  - Leclerc P
FAU - Morel, Bertrand
AU  - Morel B
FAU - Ecoffey, Claude
AU  - Ecoffey C
FAU - Dhonneur, Gilles
AU  - Dhonneur G
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - England
TA  - J Ultrasound Med
JT  - Journal of ultrasound in medicine : official journal of the American Institute of
      Ultrasound in Medicine
JID - 8211547
SB  - IM
MH  - Anesthesia, Conduction/*instrumentation
MH  - Cross Infection/*prevention & control
MH  - Disinfection/*methods
MH  - Equipment Contamination/*prevention & control
MH  - Humans
MH  - Transducers/*microbiology
MH  - Ultrasonography/*instrumentation
MH  - *Ultraviolet Rays
EDAT- 2011/06/03 06:00
MHDA- 2012/03/03 06:00
CRDT- 2011/06/03 06:00
PHST- 2011/06/03 06:00 [entrez]
PHST- 2011/06/03 06:00 [pubmed]
PHST- 2012/03/03 06:00 [medline]
AID - 30/6/785 [pii]
AID - 10.7863/jum.2011.30.6.785 [doi]
PST - ppublish
SO  - J Ultrasound Med. 2011 Jun;30(6):785-8. doi: 10.7863/jum.2011.30.6.785.


PMID- 21632745
OWN - NLM
STAT- MEDLINE
DCOM- 20111027
LR  - 20211020
IS  - 1549-5469 (Electronic)
IS  - 1088-9051 (Linking)
VI  - 21
IP  - 7
DP  - 2011 Jul
TI  - Ethical and practical challenges of sharing data from genome-wide association
      studies: the eMERGE Consortium experience.
PG  - 1001-7
LID - 10.1101/gr.120329.111 [doi]
AB  - In 2007, the National Human Genome Research Institute (NHGRI) established the
      Electronic MEdical Records and GEnomics (eMERGE) Consortium (www.gwas.net) to
      develop, disseminate, and apply approaches to research that combine DNA
      biorepositories with electronic medical record (EMR) systems for large-scale,
      high-throughput genetic research. One of the major ethical and administrative
      challenges for the eMERGE Consortium has been complying with existing
      data-sharing policies. This paper discusses the challenges of sharing genomic
      data linked to health information in the electronic medical record (EMR) and
      explores the issues as they relate to sharing both within a large consortium and 
      in compliance with the National Institutes of Health (NIH) data-sharing policy.
      We use the eMERGE Consortium experience to explore data-sharing challenges from
      the perspective of multiple stakeholders (i.e., research participants,
      investigators, and research institutions), provide recommendations for
      researchers and institutions, and call for clearer guidance from the NIH
      regarding ethical implementation of its data-sharing policy.
FAU - McGuire, Amy L
AU  - McGuire AL
AD  - Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston,
      TX 77030, USA. amcguire@bcm.edu
FAU - Basford, Melissa
AU  - Basford M
FAU - Dressler, Lynn G
AU  - Dressler LG
FAU - Fullerton, Stephanie M
AU  - Fullerton SM
FAU - Koenig, Barbara A
AU  - Koenig BA
FAU - Li, Rongling
AU  - Li R
FAU - McCarty, Cathy A
AU  - McCarty CA
FAU - Ramos, Erin
AU  - Ramos E
FAU - Smith, Maureen E
AU  - Smith ME
FAU - Somkin, Carol P
AU  - Somkin CP
FAU - Waudby, Carol
AU  - Waudby C
FAU - Wolf, Wendy A
AU  - Wolf WA
FAU - Clayton, Ellen Wright
AU  - Clayton EW
LA  - eng
GR  - U01 HG 004610/HG/NHGRI NIH HHS/United States
GR  - R01 HG004333/HG/NHGRI NIH HHS/United States
GR  - U01 HG 004608/HG/NHGRI NIH HHS/United States
GR  - U01-HG-04603/HG/NHGRI NIH HHS/United States
GR  - P50 HG004488/HG/NHGRI NIH HHS/United States
GR  - U01 HG004603/HG/NHGRI NIH HHS/United States
GR  - U01 HG004609/HG/NHGRI NIH HHS/United States
GR  - U01 HG004599/HG/NHGRI NIH HHS/United States
GR  - P50 HG 004488/HG/NHGRI NIH HHS/United States
GR  - U01-HG-004609/HG/NHGRI NIH HHS/United States
GR  - UL1 RR 024150/RR/NCRR NIH HHS/United States
GR  - U01 HG006388/HG/NHGRI NIH HHS/United States
GR  - U01 HG004610/HG/NHGRI NIH HHS/United States
GR  - U01 HG006375/HG/NHGRI NIH HHS/United States
GR  - P50 HG 003374/HG/NHGRI NIH HHS/United States
GR  - UL1 RR 025014/RR/NCRR NIH HHS/United States
GR  - UL1 RR025014/RR/NCRR NIH HHS/United States
GR  - R01 HG 004333/HG/NHGRI NIH HHS/United States
GR  - U01 HG004608/HG/NHGRI NIH HHS/United States
GR  - P50 HG003374/HG/NHGRI NIH HHS/United States
GR  - U01-HG-04599/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110601
PL  - United States
TA  - Genome Res
JT  - Genome research
JID - 9518021
SB  - IM
MH  - Cooperative Behavior
MH  - Databases, Genetic
MH  - Electronic Health Records/*ethics
MH  - Genome-Wide Association Study/*methods
MH  - Genomics/*ethics
MH  - Humans
MH  - Information Dissemination/*ethics
MH  - Internet
MH  - National Human Genome Research Institute (U.S.)
MH  - National Institutes of Health (U.S.)
MH  - Public Policy
MH  - United States
PMC - PMC3129243
EDAT- 2011/06/03 06:00
MHDA- 2011/10/28 06:00
CRDT- 2011/06/03 06:00
PHST- 2011/06/03 06:00 [entrez]
PHST- 2011/06/03 06:00 [pubmed]
PHST- 2011/10/28 06:00 [medline]
AID - gr.120329.111 [pii]
AID - 10.1101/gr.120329.111 [doi]
PST - ppublish
SO  - Genome Res. 2011 Jul;21(7):1001-7. doi: 10.1101/gr.120329.111. Epub 2011 Jun 1.


PMID- 21632170
OWN - NLM
STAT- MEDLINE
DCOM- 20120315
LR  - 20111003
IS  - 1872-7654 (Electronic)
IS  - 0301-2115 (Linking)
VI  - 158
IP  - 2
DP  - 2011 Oct
TI  - Current status of surrogacy in Japan and uterine transplantation research.
PG  - 135-40
LID - 10.1016/j.ejogrb.2011.04.037 [doi]
AB  - Recent advances in assisted reproductive technology (ART) have made it possible
      to circumvent many causes of male and female infertility. The right to have a
      child by ART has been respected for infertile couples. However, there are
      currently no legal regulations concerning ART in Japan, and this has resulted in 
      social and ethical problems. Surrogacy involves particularly complex medical,
      ethical, social, and legal issues, and is frequently focused on as a major social
      concern. Uterine transplantation (UTx) is a potential alternative for young women
      with uterine factor infertility due to hysterectomy for treatment of a malignant 
      uterine tumor or massive blood loss after delivery, or because of a congenital
      disease such as Mayer-Rokitansky-Kuster syndrome. UTx has been examined in
      experimental animals as a basis for establishment of fecundity for young women
      with uterine factor infertility. In this review, we focus on surrogacy in Japan
      and UTx research, and discuss the current status and concerns in this field.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Kisu, Iori
AU  - Kisu I
AD  - Department of Obstetrics and Gynecology, School of Medicine, Keio University, 35 
      Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
FAU - Banno, Kouji
AU  - Banno K
FAU - Mihara, Makoto
AU  - Mihara M
FAU - Iida, Takuya
AU  - Iida T
FAU - Yoshimura, Yasunori
AU  - Yoshimura Y
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110531
PL  - Ireland
TA  - Eur J Obstet Gynecol Reprod Biol
JT  - European journal of obstetrics, gynecology, and reproductive biology
JID - 0375672
SB  - IM
MH  - Biomedical Research
MH  - Female
MH  - Humans
MH  - Infertility/*therapy
MH  - Japan
MH  - *Organ Transplantation/ethics/legislation & jurisprudence
MH  - *Reproductive Techniques, Assisted/ethics/legislation & jurisprudence
MH  - Surrogate Mothers/*legislation & jurisprudence
MH  - Uterus/*transplantation
EDAT- 2011/06/03 06:00
MHDA- 2012/03/16 06:00
CRDT- 2011/06/03 06:00
PHST- 2010/12/22 00:00 [received]
PHST- 2011/02/26 00:00 [revised]
PHST- 2011/04/29 00:00 [accepted]
PHST- 2011/06/03 06:00 [entrez]
PHST- 2011/06/03 06:00 [pubmed]
PHST- 2012/03/16 06:00 [medline]
AID - S0301-2115(11)00253-3 [pii]
AID - 10.1016/j.ejogrb.2011.04.037 [doi]
PST - ppublish
SO  - Eur J Obstet Gynecol Reprod Biol. 2011 Oct;158(2):135-40. doi:
      10.1016/j.ejogrb.2011.04.037. Epub 2011 May 31.


PMID- 21632050
OWN - NLM
STAT- MEDLINE
DCOM- 20120201
LR  - 20220316
IS  - 1879-0267 (Electronic)
IS  - 0020-1383 (Linking)
VI  - 42
IP  - 11
DP  - 2011 Nov
TI  - Baseline cerebral oximetry values in elderly patients with hip fractures: a
      prospective observational study.
PG  - 1328-32
LID - 10.1016/j.injury.2011.04.015 [doi]
AB  - AIM: This study was conducted to evaluate baseline cerebral tissue regional
      oxygen saturation (rSO(2)) values and identify risk factors related to severe
      rSO(2) reductions in elderly patients with hip fractures. PATIENTS AND METHODS:
      This was a prospective observational single-centre study on patients undergoing
      scheduled or urgent operation for isolated hip fracture. The study was approved
      by the Institution Ethics Committee, and all patients signed informed consent
      before entering the study. Data were collected on factors potentially related to 
      baseline cerebral rSO(2). Data were analysed with Student's t-test, Pearson's
      correlation or multiple regression analysis as appropriate. RESULTS: Sixty-nine
      patients, aged (mean+/-standard deviation (SD)) 74+/-13 years participated. Left 
      baseline rSO(2) was 60.09+/-10.20 and right baseline rSO(2) was 58.64+/-9.92.
      Baseline rSO(2)<45 was observed in 10.1% of patients on the left and 8.7% on the 
      right side. Correlation between left- and right-side baseline cerebral rSO(2) was
      highly significant (r=0.852, p<0.001). Baseline cerebral rSO(2) had a positive,
      highly significant correlation with preoperative haematocrit (r=0.50, p<0.001)
      and arterial haemoglobin oxygen saturation (SpO(2)) (r=0.587, p<0.001), but
      correlation was negative with the American Society of Anesthesiologists (ASA)
      physical status (r=-0.42, p<0.001) and age (r=-0.39, p=0.001). Linear regression 
      showed that preoperative haematocrit accounts for 23% (R(2)=0.23) of baseline
      rSO(2) variability, whereas preoperative haematocrit and SpO(2) combined account 
      for 43.7% of rSO(2) variability (R(2)=0.437). Combined preoperative
      haematocrit+SpO(2)+age accounted for 51.3% (R(2)=0.513) of observed rSO(2)
      variability. CONCLUSION: Low baseline cerebral rSO(2) values are common in
      elderly hip fracture patients, despite normal haemodynamic and arterial
      saturation values. Preoperative haematocrit, SpO(2) and age explain a significant
      portion of cerebral rSO(2) variability. More studies are needed to validate our
      findings and assess the potential benefit of interventions aimed at improving
      cerebral rSO(2) in elderly hip fracture patients.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Papadopoulos, Georgios
AU  - Papadopoulos G
AD  - Department of Anaesthesiology and Postoperative Intensive Care, University of
      Ioannina School of Medicine, Ioannina, Greece. geopapad@cc.uoi.gr
FAU - Karanikolas, Menelaos
AU  - Karanikolas M
FAU - Liarmakopoulou, Antonia
AU  - Liarmakopoulou A
FAU - Berris, Alexandros
AU  - Berris A
LA  - eng
PT  - Journal Article
DEP - 20110531
PL  - Netherlands
TA  - Injury
JT  - Injury
JID - 0226040
RN  - 0 (Hemoglobins)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain/*metabolism
MH  - Cerebrovascular Circulation/physiology
MH  - Female
MH  - Hematocrit
MH  - Hemoglobins
MH  - Hip Fractures/epidemiology/*metabolism/surgery
MH  - Humans
MH  - Hypoxia, Brain/prevention & control
MH  - Male
MH  - Middle Aged
MH  - Oximetry/*standards
MH  - Oxygen/*blood/standards
MH  - Oxygen Consumption/*physiology
MH  - Preoperative Period
MH  - Prospective Studies
MH  - Regression Analysis
MH  - Risk Factors
MH  - Spectroscopy, Near-Infrared
MH  - Young Adult
EDAT- 2011/06/03 06:00
MHDA- 2012/02/02 06:00
CRDT- 2011/06/03 06:00
PHST- 2011/02/08 00:00 [received]
PHST- 2011/04/27 00:00 [accepted]
PHST- 2011/06/03 06:00 [entrez]
PHST- 2011/06/03 06:00 [pubmed]
PHST- 2012/02/02 06:00 [medline]
AID - S0020-1383(11)00178-1 [pii]
AID - 10.1016/j.injury.2011.04.015 [doi]
PST - ppublish
SO  - Injury. 2011 Nov;42(11):1328-32. doi: 10.1016/j.injury.2011.04.015. Epub 2011 May
      31.


PMID- 21631592
OWN - NLM
STAT- MEDLINE
DCOM- 20120531
LR  - 20220321
IS  - 1600-0501 (Electronic)
IS  - 0905-7161 (Linking)
VI  - 23
IP  - 2
DP  - 2012 Feb
TI  - Masseter muscle thickness, chewing efficiency and bite force in edentulous
      patients with fixed and removable implant-supported prostheses: a cross-sectional
      multicenter study.
PG  - 144-150
LID - 10.1111/j.1600-0501.2011.02213.x [doi]
AB  - OBJECTIVES: Edentulous patients may be restored with conventional dentures (C/C),
      implant-supported overdentures (IOD) or implant-supported fixed dental prostheses
      (IFDP). Null-hypotheses: chewing efficiency, maximum voluntary bite force (MBF)
      and masseter muscle thickness (MMT) are lower in patients with C/IOD compared
      with the patients with bimaxillary IFDPs. Both groups perform better than C/C and
      are inferior to fully dentate controls. MATERIAL AND METHODS: Ethical approval
      was obtained. For this multicenter cross-sectional study, 80 patients were
      recruited. Four groups of different dental states comprised of either
      implant-supported prostheses (C/IOD and IFDP/IFDP) or served as control-groups
      (C/C and fully dentate D/D). Chewing efficiency was assessed with a two-colour
      mixing ability test. MBF was measured bilaterally with a force gauge. Two
      dimensional ultrasonography was used to measure MMT bilaterally. RESULTS: Chewing
      efficiency in C/IOD and IFDP/IFDP (difference NS) was better than in C/C, but not
      as good as in D/D. MBF in C/IOD was lower than in IFDP/IFDP. Chewing efficiency
      and MBF were significantly lower in IFDP/IFDP, who had experienced chipping or
      fracture of the prosthetic superstructure. Median MMT of patients with
      implant-supported prostheses was between those with C/C and fully dentate
      participants. There was no significant difference in MMT between C/IOD and
      IFDP/IFDP. CONCLUSION: Supporting complete prostheses with oral implants seems to
      have positive effects on the thickness of the masseter muscle, maximum bite force
      as well as chewing efficiency. The type of implant-supported prostheses may have 
      an influence on the magnitude of the effect.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Muller, Frauke
AU  - Muller F
AD  - Division of Gerodontology and Removable Prosthodontics, University of Geneva,
      Geneva, SwitzerlandDepartment of Rehabilitation and Geriatrics, University
      Hospitals of Geneva, Thonex, SwitzerlandDepartment of Periodontology, Oral
      Surgery, Oral Medicine, University Complutense Madrid, Madrid, SpainDepartment of
      Maxillofacial Surgery, Plastic Surgery and Centre of Oral Implantology,
      Katharinen Hospital, Stuttgart, GermanyDivision of Fixed Prosthodontics and
      Occlusion, University of Geneva, Geneva, Switzerland.
FAU - Hernandez, Marta
AU  - Hernandez M
AD  - Division of Gerodontology and Removable Prosthodontics, University of Geneva,
      Geneva, SwitzerlandDepartment of Rehabilitation and Geriatrics, University
      Hospitals of Geneva, Thonex, SwitzerlandDepartment of Periodontology, Oral
      Surgery, Oral Medicine, University Complutense Madrid, Madrid, SpainDepartment of
      Maxillofacial Surgery, Plastic Surgery and Centre of Oral Implantology,
      Katharinen Hospital, Stuttgart, GermanyDivision of Fixed Prosthodontics and
      Occlusion, University of Geneva, Geneva, Switzerland.
FAU - Grutter, Linda
AU  - Grutter L
AD  - Division of Gerodontology and Removable Prosthodontics, University of Geneva,
      Geneva, SwitzerlandDepartment of Rehabilitation and Geriatrics, University
      Hospitals of Geneva, Thonex, SwitzerlandDepartment of Periodontology, Oral
      Surgery, Oral Medicine, University Complutense Madrid, Madrid, SpainDepartment of
      Maxillofacial Surgery, Plastic Surgery and Centre of Oral Implantology,
      Katharinen Hospital, Stuttgart, GermanyDivision of Fixed Prosthodontics and
      Occlusion, University of Geneva, Geneva, Switzerland.
FAU - Aracil-Kessler, Luis
AU  - Aracil-Kessler L
AD  - Division of Gerodontology and Removable Prosthodontics, University of Geneva,
      Geneva, SwitzerlandDepartment of Rehabilitation and Geriatrics, University
      Hospitals of Geneva, Thonex, SwitzerlandDepartment of Periodontology, Oral
      Surgery, Oral Medicine, University Complutense Madrid, Madrid, SpainDepartment of
      Maxillofacial Surgery, Plastic Surgery and Centre of Oral Implantology,
      Katharinen Hospital, Stuttgart, GermanyDivision of Fixed Prosthodontics and
      Occlusion, University of Geneva, Geneva, Switzerland.
FAU - Weingart, Dieter
AU  - Weingart D
AD  - Division of Gerodontology and Removable Prosthodontics, University of Geneva,
      Geneva, SwitzerlandDepartment of Rehabilitation and Geriatrics, University
      Hospitals of Geneva, Thonex, SwitzerlandDepartment of Periodontology, Oral
      Surgery, Oral Medicine, University Complutense Madrid, Madrid, SpainDepartment of
      Maxillofacial Surgery, Plastic Surgery and Centre of Oral Implantology,
      Katharinen Hospital, Stuttgart, GermanyDivision of Fixed Prosthodontics and
      Occlusion, University of Geneva, Geneva, Switzerland.
FAU - Schimmel, Martin
AU  - Schimmel M
AD  - Division of Gerodontology and Removable Prosthodontics, University of Geneva,
      Geneva, SwitzerlandDepartment of Rehabilitation and Geriatrics, University
      Hospitals of Geneva, Thonex, SwitzerlandDepartment of Periodontology, Oral
      Surgery, Oral Medicine, University Complutense Madrid, Madrid, SpainDepartment of
      Maxillofacial Surgery, Plastic Surgery and Centre of Oral Implantology,
      Katharinen Hospital, Stuttgart, GermanyDivision of Fixed Prosthodontics and
      Occlusion, University of Geneva, Geneva, Switzerland.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20110602
PL  - Denmark
TA  - Clin Oral Implants Res
JT  - Clinical oral implants research
JID - 9105713
MH  - Aged
MH  - Bite Force
MH  - Chi-Square Distribution
MH  - Cross-Sectional Studies
MH  - *Dental Prosthesis, Implant-Supported
MH  - Denture, Overlay
MH  - Denture, Partial, Fixed
MH  - Female
MH  - Humans
MH  - Male
MH  - Masseter Muscle/diagnostic imaging/*physiology
MH  - Mastication/*physiology
MH  - Middle Aged
MH  - Mouth, Edentulous/*rehabilitation
MH  - Statistics, Nonparametric
MH  - Ultrasonography
EDAT- 2011/06/03 06:00
MHDA- 2012/06/01 06:00
CRDT- 2011/06/03 06:00
PHST- 2011/06/03 06:00 [entrez]
PHST- 2011/06/03 06:00 [pubmed]
PHST- 2012/06/01 06:00 [medline]
AID - 10.1111/j.1600-0501.2011.02213.x [doi]
PST - ppublish
SO  - Clin Oral Implants Res. 2012 Feb;23(2):144-150. doi:
      10.1111/j.1600-0501.2011.02213.x. Epub 2011 Jun 2.


PMID- 21631377
OWN - NLM
STAT- MEDLINE
DCOM- 20111007
LR  - 20110602
IS  - 1557-8550 (Electronic)
IS  - 1549-5418 (Linking)
VI  - 29
IP  - 6
DP  - 2011 Jun
TI  - Leave your sidearms not your ethics at the door.
PG  - 363-4
LID - 10.1089/pho.2011.9910 [doi]
FAU - Lanzafame, Raymond J
AU  - Lanzafame RJ
LA  - eng
PT  - Editorial
PL  - United States
TA  - Photomed Laser Surg
JT  - Photomedicine and laser surgery
JID - 101222340
SB  - IM
MH  - *Bioethical Issues
MH  - *Conflict of Interest
MH  - *Disclosure
MH  - Humans
MH  - *Peer Review, Research
MH  - *Publishing
EDAT- 2011/06/03 06:00
MHDA- 2011/10/08 06:00
CRDT- 2011/06/03 06:00
PHST- 2011/06/03 06:00 [entrez]
PHST- 2011/06/03 06:00 [pubmed]
PHST- 2011/10/08 06:00 [medline]
AID - 10.1089/pho.2011.9910 [doi]
PST - ppublish
SO  - Photomed Laser Surg. 2011 Jun;29(6):363-4. doi: 10.1089/pho.2011.9910.


PMID- 21630625
OWN - NLM
STAT- MEDLINE
DCOM- 20110712
LR  - 20170214
IS  - 0840-4704 (Print)
IS  - 0840-4704 (Linking)
VI  - 24
IP  - 1
DP  - 2011 Spring
TI  - Ethical management in health services administration: a sequel.
PG  - 31-8
FAU - Juzwishin, Donald W M
AU  - Juzwishin DW
AD  - Don.Juzwishin@albertahealthservices.ca
LA  - eng
LA  - fre
PT  - Journal Article
PL  - United States
TA  - Healthc Manage Forum
JT  - Healthcare management forum
JID - 8805307
MH  - Canada
MH  - Health Facility Administration/*ethics
MH  - Humans
MH  - *Leadership
EDAT- 2011/06/03 06:00
MHDA- 2011/07/13 06:00
CRDT- 2011/06/03 06:00
PHST- 2011/06/03 06:00 [entrez]
PHST- 2011/06/03 06:00 [pubmed]
PHST- 2011/07/13 06:00 [medline]
AID - 10.1016/j.hcmf.2010.12.003 [doi]
PST - ppublish
SO  - Healthc Manage Forum. 2011 Spring;24(1):31-8. doi: 10.1016/j.hcmf.2010.12.003.


PMID- 21625132
OWN - NLM
STAT- MEDLINE
DCOM- 20110922
LR  - 20110531
IS  - 1421-976X (Electronic)
IS  - 0008-6568 (Linking)
VI  - 45 Suppl 1
DP  - 2011
TI  - In vitro and in situ erosion models for evaluating tooth substance loss.
PG  - 43-52
LID - 10.1159/000325945 [doi]
AB  - Because of the difficulties in measuring erosion in vivo, a number of in vitro
      and in situ models have been developed and validated. These models are flexible
      and informative, allowing single as well as multiple variables to be examined
      under specific conditions using accurate measurement techniques over defined
      timelines, thus yielding useful data without harmful effects on individuals. This
      information, together with clinical findings, is essential for clinicians
      advising susceptible patients appropriately regarding the management of their
      condition. Little guidance is available, however, on the standardisation of in
      vitro and in situ protocols for erosive tooth wear studies, so it is difficult to
      make meaningful comparisons between investigations as experimental variables
      differ widely from study to study. The aim of this review was to collate the
      available data on models designed to assess erosive challenges which are severe
      enough to cause tissue loss as opposed to just softening of the surface
      structure. The different types of models, with their merits and pitfalls, are
      documented. Test substrates, disinfecting regimens and ethical considerations are
      discussed. The aims of this paper are to give guidance to the researcher on
      evidence-based in vitro and in situ erosive tooth wear methodology and to suggest
      best practice given current knowledge.
CI  - Copyright (c) 2011 S. Karger AG, Basel.
FAU - West, N X
AU  - West NX
AD  - Clinical Trials Unit, School of Oral and Dental Sciences, University of Bristol, 
      Bristol, UK. N.X.West@Bristol.ac.uk
FAU - Davies, M
AU  - Davies M
FAU - Amaechi, B T
AU  - Amaechi BT
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110531
PL  - Switzerland
TA  - Caries Res
JT  - Caries research
JID - 0103374
SB  - IM
MH  - Animals
MH  - Dental Enamel/pathology
MH  - Dental Research/ethics
MH  - Disinfection/methods
MH  - Evidence-Based Dentistry
MH  - Guidelines as Topic
MH  - Human Experimentation/ethics/legislation & jurisprudence
MH  - Humans
MH  - Research Design/*standards
MH  - Tooth Erosion/*etiology/physiopathology/therapy
EDAT- 2011/06/03 06:00
MHDA- 2011/09/23 06:00
CRDT- 2011/06/01 06:00
PHST- 2011/06/01 06:00 [entrez]
PHST- 2011/06/03 06:00 [pubmed]
PHST- 2011/09/23 06:00 [medline]
AID - 000325945 [pii]
AID - 10.1159/000325945 [doi]
PST - ppublish
SO  - Caries Res. 2011;45 Suppl 1:43-52. doi: 10.1159/000325945. Epub 2011 May 31.


PMID- 21624191
OWN - NLM
STAT- MEDLINE
DCOM- 20110719
LR  - 20211020
IS  - 1471-2458 (Electronic)
IS  - 1471-2458 (Linking)
VI  - 11 Suppl 4
DP  - 2011 May 31
TI  - Using the ICF in Ireland.
PG  - S5
LID - 10.1186/1471-2458-11-S4-S5 [doi]
AB  - This paper reflects on the use of ICF in Ireland, taking as a case study the
      experience of the first National Disability Survey (NDS). There were four clear
      effects in Ireland of using ICF as a framework for the NDS: a) that a broader
      range of people with disabilities was encompassed; b) that the environmental
      factors included from the ICF were comprehensive and policy relevant; c) that
      both barriers and facilitators were incorporated into the model; and d) that a
      focus on research ethics was encouraged. Some general conclusions regarding the
      benefits and limitations of ICF based on this experience are also drawn.
FAU - Good, Anne
AU  - Good A
AD  - ICF FDRG - Task Group Ethics and Human Rights. goodanne@eircom.net
LA  - eng
PT  - Journal Article
DEP - 20110531
PL  - England
TA  - BMC Public Health
JT  - BMC public health
JID - 100968562
SB  - IM
MH  - Activities of Daily Living
MH  - *Disability Evaluation
MH  - Disabled Persons/*classification
MH  - *Health Surveys
MH  - Humans
MH  - *International Classification of Diseases
MH  - Ireland
MH  - Policy
MH  - Social Environment
PMC - PMC3104218
EDAT- 2011/06/03 06:00
MHDA- 2011/07/20 06:00
CRDT- 2011/06/01 06:00
PHST- 2011/06/01 06:00 [entrez]
PHST- 2011/06/03 06:00 [pubmed]
PHST- 2011/07/20 06:00 [medline]
AID - 1471-2458-11-S4-S5 [pii]
AID - 10.1186/1471-2458-11-S4-S5 [doi]
PST - epublish
SO  - BMC Public Health. 2011 May 31;11 Suppl 4:S5. doi: 10.1186/1471-2458-11-S4-S5.


PMID- 21614795
OWN - NLM
STAT- MEDLINE
DCOM- 20110929
LR  - 20120911
IS  - 1724-6059 (Electronic)
IS  - 1121-8428 (Linking)
VI  - 24 Suppl 17
DP  - 2011 May-Jun
TI  - Development of the concept of pain in history.
PG  - S133-6
LID - 10.5301/JN.2011.6481 [doi]
AB  - From Hippocratic medicine through the modern theory of Melzack and Wall, the
      concept and physiopathology of pain has been developed over the course of time,
      assuming in some instances a religious or philosophical view and in others a more
      scientific meaning. People have developed very different words to express pain.
      The Arabic language has hundreds of words to express pain, while European
      languages are more limited. Descartes, who first proposed a link between
      peripheral sensation and the brain, suggested that sensations stimulated in the
      body are conveyed directly to the brain, where they are actually perceived. The
      Cartesian model gave rise to the notion of a "hard-wired system." European
      physicians did their best to relieve their patients' pain, often through the
      judicious use of opium and, after 1680, laudanum, the mixture of opium in sherry 
      introduced by Thomas Sydenham. In 1803, Serturner discovered a substance from
      isolated crystals of a powerful analgesic agent, derived from crude opium, that
      he named morphine, after Morpheus, the Greek god of dreams. The introduction of
      surgical anesthesia represented one of the most important advances of modern
      medicine, although initially it was not accepted by the medical community, for
      ethical reasons.
FAU - Santoro, Domenico
AU  - Santoro D
AD  - Unit of Nephrology and Dialysis, Department of Medicine and Pharmacology,
      University of Messina, Messina, Italy. dsantoro@unime.it
FAU - Bellinghieri, Guido
AU  - Bellinghieri G
FAU - Savica, Vincenzo
AU  - Savica V
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - Italy
TA  - J Nephrol
JT  - Journal of nephrology
JID - 9012268
RN  - 0 (Analgesics)
RN  - 0 (Anesthetics)
SB  - IM
EIN - J Nephrol. 2012 Jul-Aug;25(4):588. Bellinghieri, Guido [added]
MH  - Analgesics/history
MH  - Anesthetics/history
MH  - *Concept Formation
MH  - History, 15th Century
MH  - History, 16th Century
MH  - History, 17th Century
MH  - History, 18th Century
MH  - History, 19th Century
MH  - History, 20th Century
MH  - History, 21st Century
MH  - History, Ancient
MH  - History, Medieval
MH  - Humans
MH  - Pain/*history
MH  - Pain Management
EDAT- 2011/06/03 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/05/27 06:00
PHST- 2010/12/31 00:00 [accepted]
PHST- 2011/05/27 06:00 [entrez]
PHST- 2011/06/03 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - A35E1D78-F6B5-45A1-BCEF-A8EE6FBAFC22 [pii]
AID - 10.5301/JN.2011.6481 [doi]
PST - ppublish
SO  - J Nephrol. 2011 May-Jun;24 Suppl 17:S133-6. doi: 10.5301/JN.2011.6481.


PMID- 21630043
OWN - NLM
STAT- MEDLINE
DCOM- 20111121
LR  - 20211020
IS  - 1433-0350 (Electronic)
IS  - 0256-7040 (Linking)
VI  - 27
IP  - 8
DP  - 2011 Aug
TI  - Palliative functional hemispherectomy for treatment of refractory status
      epilepticus associated with Alpers' disease.
PG  - 1321-3
LID - 10.1007/s00381-011-1495-9 [doi]
AB  - PURPOSE: Palliative epilepsy surgery is considered for patients that would
      benefit from surgical therapy for intractable epilepsy but are not candidates for
      curative procedures. In many cases, the goals of therapy focus on improved
      quality of life more than seizure freedom. We discuss the use of epilepsy surgery
      for refractory status epilepticus, as well as the rationale and ethical
      considerations for employing a palliative procedure in otherwise fatal diseases. 
      METHODS: We present a child with Alpers' disease presenting with refractory
      status epilepticus which was treated with functional hemispherectomy after
      failure of multiple typical therapies. Hemispherectomy allowed for the child to
      be extubated and ultimately discharged to home with her family. Unfortunately,
      the child died several months later after developing new-onset liver failure in
      the setting of a viral illness. CONCLUSION: Functional hemispherectomy was
      effective for the treatment of refractory status epilepticus in Alpers' disease. 
      We believe that the procedure resulted in improved quality of life which was the 
      primary outcome goal. Palliative procedures should be considered in diseases with
      ultimate fatal outcome when the short-term benefits outweigh the risks. The
      ethical aspects of treatment must be carefully considered to insure treatment is 
      provided in the best interest of the patient.
FAU - Lupashko, Svetlana
AU  - Lupashko S
AD  - University of North Texas Health Science Center, Fort Worth, TX, USA.
FAU - Malik, Saleem
AU  - Malik S
FAU - Donahue, David
AU  - Donahue D
FAU - Hernandez, Angel
AU  - Hernandez A
FAU - Perry, M Scott
AU  - Perry MS
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20110601
PL  - Germany
TA  - Childs Nerv Syst
JT  - Child's nervous system : ChNS : official journal of the International Society for
      Pediatric Neurosurgery
JID - 8503227
SB  - IM
CIN - Childs Nerv Syst. 2011 Aug;27(8):1325-6. PMID: 21643839
CIN - Childs Nerv Syst. 2011 Aug;27(8):1327-8. PMID: 21667152
MH  - Child, Preschool
MH  - Diffuse Cerebral Sclerosis of Schilder/complications/*surgery
MH  - Female
MH  - *Hemispherectomy
MH  - Humans
MH  - Palliative Care/*methods
MH  - Status Epilepticus/etiology/*surgery
EDAT- 2011/06/02 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/06/02 06:00
PHST- 2011/03/04 00:00 [received]
PHST- 2011/05/18 00:00 [accepted]
PHST- 2011/06/02 06:00 [entrez]
PHST- 2011/06/02 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/s00381-011-1495-9 [doi]
PST - ppublish
SO  - Childs Nerv Syst. 2011 Aug;27(8):1321-3. doi: 10.1007/s00381-011-1495-9. Epub
      2011 Jun 1.


PMID- 21629417
OWN - NLM
STAT- MEDLINE
DCOM- 20110831
LR  - 20211020
IS  - 0008-5286 (Print)
IS  - 0008-5286 (Linking)
VI  - 52
IP  - 3
DP  - 2011 Mar
TI  - An ethicist's commentary on promoting farm animal welfare at the expense of
      productivity.
PG  - 230
FAU - Rollin, Bernard E
AU  - Rollin BE
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Vet J
JT  - The Canadian veterinary journal = La revue veterinaire canadienne
JID - 0004653
SB  - IM
MH  - Animal Welfare/*ethics
MH  - Animals
MH  - Canada
MH  - *Food Supply/economics/statistics & numerical data
MH  - Humans
MH  - Veterinary Medicine/*ethics
PMC - PMC3039893
EDAT- 2011/06/02 06:00
MHDA- 2011/09/01 06:00
CRDT- 2011/06/02 06:00
PHST- 2011/06/02 06:00 [entrez]
PHST- 2011/06/02 06:00 [pubmed]
PHST- 2011/09/01 06:00 [medline]
PST - ppublish
SO  - Can Vet J. 2011 Mar;52(3):230.


PMID- 21629297
OWN - NLM
STAT- MEDLINE
DCOM- 20120214
LR  - 20211020
IS  - 1476-5438 (Electronic)
IS  - 1018-4813 (Linking)
VI  - 19
IP  - 11
DP  - 2011 Nov
TI  - Are the kids really all right? Direct-to-consumer genetic testing in children:
      are company policies clashing with professional norms?
PG  - 1122-6
LID - 10.1038/ejhg.2011.94 [doi]
AB  - The genetic testing of minors within the direct-to-consumer (DTC) genetic testing
      (GT) context has been given relatively little attention. The issue of testing
      healthy children for diseases that would only develop in adulthood raises many
      important ethical, legal and social issues. As genetic testing is now available
      outside of the traditional health care system, often without even the
      intermediate of a health care professional, we surveyed 37 DTC GT companies
      regarding their policies for testing in children. Although the response rate is
      relatively low (35%, 13/37), our findings reveal that a clear majority of
      companies do perform genetic testing in minors. As such, companies testing for
      adult onset diseases are acting in contradiction of established professional
      guidelines, which state, among others, that, for predictive genetic testing, the 
      availability of therapeutic or preventive measures is necessary for testing to be
      performed in asymptomatic minors. The community of stakeholders in children's
      health care and genetic testing should, therefore, decide which standards need to
      be upheld by DTC GT companies and ensure that these are met.
FAU - Howard, Heidi Carmen
AU  - Howard HC
AD  - Centre for Biomedical Ethics and Law, Katholieke Universiteit Leuven,
      Kapucijnenvoer 35, Leuven, Belgium. heidi.howard@med.kuleuven.be
FAU - Avard, Denise
AU  - Avard D
FAU - Borry, Pascal
AU  - Borry P
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110601
PL  - England
TA  - Eur J Hum Genet
JT  - European journal of human genetics : EJHG
JID - 9302235
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - *Ethics, Professional
MH  - Genetic Counseling/ethics/legislation & jurisprudence/standards
MH  - Genetic Testing/*ethics/*legislation & jurisprudence
MH  - Health Care Sector/*legislation & jurisprudence/*standards
MH  - Humans
MH  - Surveys and Questionnaires
PMC - PMC3198149
EDAT- 2011/06/02 06:00
MHDA- 2012/02/15 06:00
CRDT- 2011/06/02 06:00
PHST- 2011/06/02 06:00 [entrez]
PHST- 2011/06/02 06:00 [pubmed]
PHST- 2012/02/15 06:00 [medline]
AID - ejhg201194 [pii]
AID - 10.1038/ejhg.2011.94 [doi]
PST - ppublish
SO  - Eur J Hum Genet. 2011 Nov;19(11):1122-6. doi: 10.1038/ejhg.2011.94. Epub 2011 Jun
      1.


PMID- 21629296
OWN - NLM
STAT- MEDLINE
DCOM- 20120111
LR  - 20211020
IS  - 1476-5438 (Electronic)
IS  - 1018-4813 (Linking)
VI  - 19
IP  - 10
DP  - 2011 Oct
TI  - Rapid aneuploidy detection or karyotyping? Ethical reflection.
PG  - 1020-5
LID - 10.1038/ejhg.2011.82 [doi]
AB  - No consensus exists whether women at increased risk for trisomy 21, 13, and 18
      should be offered stand-alone rapid aneuploidy detection (RAD) or karyotyping. In
      this paper, the ethical implications of a fast, relatively cheap and targeted RAD
      are examined. The advantages of RAD seem less robust than its proponents suggest.
      Fast test results only give a short-term psychological benefit. The cost
      advantage of RAD is apparent, but must be weighed against consequences like
      missed abnormalities, which are evaluated differently by professionals and
      pregnant women. Since pre-test information about RAD will have to include telling
      women about karyotyping as a possible alternative, the advantage of RAD in terms 
      of the quantity of information that needs to be given may also be smaller than
      suggested. We conclude that none of the supposed arguments in favour of RAD is
      decisive in itself. Whether the case for RAD may still be regarded as convincing 
      when taking these arguments together seems to depend on one's implicit view of
      what prenatal screening is about. Are we basically dealing with a test for
      trisomy 21 and a few conditions more? Or are there good grounds for also testing 
      for the wider range of abnormalities that karyotyping can detect? As
      professionals and pregnant women may have different views about this, we suggest 
      that the best approach is to offer women a choice between RAD and karyotyping.
      This approach is most in line with the general aim of prenatal screening:
      providing opportunities for autonomous reproductive choice.
FAU - de Jong, Antina
AU  - de Jong A
AD  - Department of Health, Ethics and Society, Faculty of Health, Medicine and Life
      Sciences, GROW, School for Oncology and Developmental Biology, Maastricht
      University, Maastricht, The Netherlands. at.dejong@maastrichtuniversity.nl
FAU - Dondorp, Wybo J
AU  - Dondorp WJ
FAU - Timmermans, Danielle R M
AU  - Timmermans DR
FAU - van Lith, Jan M M
AU  - van Lith JM
FAU - de Wert, Guido M W R
AU  - de Wert GM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110601
PL  - England
TA  - Eur J Hum Genet
JT  - European journal of human genetics : EJHG
JID - 9302235
SB  - IM
MH  - *Aneuploidy
MH  - Chromosome Disorders/*diagnosis/genetics
MH  - Decision Making
MH  - Down Syndrome/diagnosis/genetics
MH  - Female
MH  - Genetic Testing/ethics/methods
MH  - Humans
MH  - Karyotyping/*ethics/*methods
MH  - Pregnancy
MH  - Prenatal Diagnosis/*ethics/*methods
MH  - Time Factors
PMC - PMC3190255
EDAT- 2011/06/02 06:00
MHDA- 2012/01/12 06:00
CRDT- 2011/06/02 06:00
PHST- 2011/06/02 06:00 [entrez]
PHST- 2011/06/02 06:00 [pubmed]
PHST- 2012/01/12 06:00 [medline]
AID - ejhg201182 [pii]
AID - 10.1038/ejhg.2011.82 [doi]
PST - ppublish
SO  - Eur J Hum Genet. 2011 Oct;19(10):1020-5. doi: 10.1038/ejhg.2011.82. Epub 2011 Jun
      1.


PMID- 21628758
OWN - NLM
STAT- MEDLINE
DCOM- 20110928
LR  - 20110601
IS  - 1120-9763 (Print)
IS  - 1120-9763 (Linking)
VI  - 35
IP  - 2
DP  - 2011 Mar-Apr
TI  - [Moniter Project: a model of HIA for Incinerators].
PG  - 136-8
AB  - The Emilia-Romagna regional government decided to develop a monitoring and
      surveillance system, known as MonITER (Incineration Monitoring on the
      Emilia-Romagna Territory), in 8 areas characterized by the presence of municipal 
      waste incinerating plants.The project was divided into 7 lines, among these the
      number 6 developed a procedure of Health Impact Assessments (HIA) to support the 
      planning of new facilities for incineration or combustion. Line number 6 is
      divided into 3 actions n action 1 aimed to developing and validating a
      participative HIA methodology, as well tools for the impact assessment and
      recommendations for implementing HIA on future plants; n action 2 analysed
      connected issues on communication; n action 3 was focused to developing a
      methodology for integrating HIA models into existing tools for mandatory impact
      assessment.Tailoring the HIA model development to the waste management context
      has highlighted the fundamental differences of the HIA approach with the other
      mandatory assessment tools, being theoretically founded on the principles of
      public involvement, equity, sustainable development and ethical use of evidence.
FAU - Linzalone, Nunzia
AU  - Linzalone N
AD  - Istituto di fisiologia clinica, Consiglio nazionale delle ricerche, Pisa, Italy. 
      li.nunzia@ifc.cnr.it
FAU - Siciliano, Tiziana
AU  - Siciliano T
LA  - ita
PT  - English Abstract
PT  - Journal Article
TT  - Progetto Moniter: un modello di VIS per gli impianti di incenerimento.
PL  - Italy
TA  - Epidemiol Prev
JT  - Epidemiologia e prevenzione
JID - 8902507
SB  - IM
MH  - Decision Making
MH  - Environment
MH  - Environmental Monitoring/*legislation & jurisprudence/standards
MH  - *Environmental Policy
MH  - Garbage
MH  - *Health Policy
MH  - Humans
MH  - Incineration/legislation & jurisprudence/methods/*standards/statistics &
      numerical data
MH  - Italy
MH  - Models, Theoretical
MH  - Policy Making
MH  - Waste Management/*legislation & jurisprudence
EDAT- 2011/06/02 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/06/02 06:00
PHST- 2011/06/02 06:00 [entrez]
PHST- 2011/06/02 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 899 [pii]
PST - ppublish
SO  - Epidemiol Prev. 2011 Mar-Apr;35(2):136-8.


PMID- 21628701
OWN - NLM
STAT- MEDLINE
DCOM- 20110913
LR  - 20180724
IS  - 1472-1465 (Electronic)
IS  - 0007-1250 (Linking)
VI  - 198
IP  - 6
DP  - 2011 Jun
TI  - Forensic psychiatry and public protection.
PG  - 420-3
LID - 10.1192/bjp.bp.111.095471 [doi]
AB  - The prominence of risk in UK social and criminal justice policy creates
      opportunities, challenges and dangers for forensic psychiatry. The future
      standing of the specialty will depend not only on the practical utility of its
      responses to those opportunities and challenges, but also the ethical integrity
      of those responses.
FAU - Buchanan, Alec
AU  - Buchanan A
FAU - Grounds, Adrian
AU  - Grounds A
LA  - eng
PT  - Editorial
PT  - Comment
PL  - England
TA  - Br J Psychiatry
JT  - The British journal of psychiatry : the journal of mental science
JID - 0342367
SB  - IM
CON - Br J Psychiatry. 2011 Jun;198(6):431-3. PMID: 21628704
MH  - Commitment of Mentally Ill
MH  - Crime/prevention & control
MH  - Forensic Psychiatry/*ethics/legislation & jurisprudence
MH  - Humans
MH  - Personality Disorders/*therapy
MH  - *Public Policy
MH  - Risk Management
MH  - United Kingdom
EDAT- 2011/06/02 06:00
MHDA- 2011/09/14 06:00
CRDT- 2011/06/02 06:00
PHST- 2011/06/02 06:00 [entrez]
PHST- 2011/06/02 06:00 [pubmed]
PHST- 2011/09/14 06:00 [medline]
AID - S0007125000255347 [pii]
AID - 10.1192/bjp.bp.111.095471 [doi]
PST - ppublish
SO  - Br J Psychiatry. 2011 Jun;198(6):420-3. doi: 10.1192/bjp.bp.111.095471.


PMID- 21628692
OWN - NLM
STAT- MEDLINE
DCOM- 20111102
LR  - 20190709
IS  - 1943-4723 (Electronic)
IS  - 0002-8177 (Linking)
VI  - 142
IP  - 6
DP  - 2011 Jun
TI  - What is my ethical responsibility when my employer authorizes treatments that I
      believe are unnecessary?
PG  - 674-6
FAU - Wentworth, Rod B
AU  - Wentworth RB
AD  - American Dental Association Council on Ethics, Bylaws and Judicial Affairs, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Am Dent Assoc
JT  - Journal of the American Dental Association (1939)
JID - 7503060
SB  - IM
MH  - Crowns/ethics
MH  - Dental Care/*ethics
MH  - Dental Restoration, Permanent/ethics
MH  - Dentist-Patient Relations/ethics
MH  - Dentists/*ethics
MH  - *Ethics, Dental
MH  - Group Practice, Dental/ethics
MH  - Humans
MH  - Interprofessional Relations
MH  - Patient Care Planning/ethics
MH  - Patient Participation
MH  - Private Practice/ethics
MH  - Professional Misconduct/ethics
MH  - Social Behavior
MH  - Unnecessary Procedures/ethics
MH  - Whistleblowing/ethics
MH  - Workplace
EDAT- 2011/06/02 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/06/02 06:00
PHST- 2011/06/02 06:00 [entrez]
PHST- 2011/06/02 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
AID - S0002-8177(14)65573-2 [pii]
AID - 10.14219/jada.archive.2011.0253 [doi]
PST - ppublish
SO  - J Am Dent Assoc. 2011 Jun;142(6):674-6. doi: 10.14219/jada.archive.2011.0253.


PMID- 21628492
OWN - NLM
STAT- MEDLINE
DCOM- 20111020
LR  - 20210102
IS  - 1538-7445 (Electronic)
IS  - 0008-5472 (Linking)
VI  - 71
IP  - 14
DP  - 2011 Jul 15
TI  - In vivo programming of tumor antigen-specific T lymphocytes from pluripotent stem
      cells to promote cancer immunosurveillance.
PG  - 4742-7
LID - 10.1158/0008-5472.CAN-11-0359 [doi]
AB  - Adoptive T-cell immunotherapy has garnered wide attention, but its effective use 
      is limited by the need of multiple ex vivo manipulations and infusions that are
      complex and expensive. In this study, we show how highly reactive antigen
      (Ag)-specific CTLs can be generated from induced pluripotent stem (iPS) cells to 
      provide an unlimited source of functional CTLs for adoptive immunotherapy. iPS
      cell-derived T cells can offer the advantages of avoiding possible immune
      rejection and circumventing ethical and practical issues associated with other
      stem cell types. iPS cells can be differentiated into progenitor T cells in vitro
      by stimulation with the Notch ligand Delta-like 1 (DL1) overexpressed on bone
      marrow stromal cells, with complete maturation occurring upon adoptive transfer
      into Rag1-deficient mice. Here, we report that these iPS cells can be
      differentiated in vivo into functional CTLs after overexpression of MHC
      I-restricted Ag-specific T-cell receptors (TCR). In this study, we generated
      murine iPS cells genetically modified with ovalbumin (OVA)-specific and MHC-I
      restricted TCR (OT-I) by retrovirus-mediated transduction. After their adoptive
      transfer into recipient mice, the majority of OT-I/iPS cells underwent
      differentiation into CD8+ CTLs. TCR-transduced iPS cells developed in vivo
      responded in vitro to peptide stimulation by secreting interleukin 2 and
      IFN-gamma. Most importantly, adoptive transfer of TCR-transduced iPS cells
      triggered infiltration of OVA-reactive CTLs into tumor tissues and protected
      animals from tumor challenge. Taken together, our findings offer proof of concept
      for a potentially more efficient approach to generate Ag-specific T lymphocytes
      for adoptive immunotherapy.
CI  - (c)2011 AACR.
FAU - Lei, Fengyang
AU  - Lei F
AD  - Departments of Microbiology and Immunology, The Pennsylvania State University
      College of Medicine, Hershey, PA 17033, USA.
FAU - Zhao, Baohua
AU  - Zhao B
FAU - Haque, Rizwanul
AU  - Haque R
FAU - Xiong, Xiaofang
AU  - Xiong X
FAU - Budgeon, Lynn
AU  - Budgeon L
FAU - Christensen, Neil D
AU  - Christensen ND
FAU - Wu, Yuzhang
AU  - Wu Y
FAU - Song, Jianxun
AU  - Song J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110531
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Epitopes, T-Lymphocyte)
RN  - 0 (Receptors, Antigen, T-Cell)
SB  - IM
MH  - Animals
MH  - Antigens, Neoplasm/genetics/*immunology
MH  - Cell Differentiation/genetics/immunology
MH  - Epitopes, T-Lymphocyte/genetics/*immunology
MH  - Immunotherapy, Adoptive
MH  - Liver Neoplasms, Experimental/*immunology/therapy
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Monitoring, Immunologic
MH  - Pluripotent Stem Cells/cytology/*immunology
MH  - Receptors, Antigen, T-Cell/genetics/*immunology
MH  - T-Lymphocytes/cytology/immunology
MH  - T-Lymphocytes, Cytotoxic/cytology/*immunology
MH  - Transduction, Genetic
EDAT- 2011/06/02 06:00
MHDA- 2011/10/21 06:00
CRDT- 2011/06/02 06:00
PHST- 2011/06/02 06:00 [entrez]
PHST- 2011/06/02 06:00 [pubmed]
PHST- 2011/10/21 06:00 [medline]
AID - 0008-5472.CAN-11-0359 [pii]
AID - 10.1158/0008-5472.CAN-11-0359 [doi]
PST - ppublish
SO  - Cancer Res. 2011 Jul 15;71(14):4742-7. doi: 10.1158/0008-5472.CAN-11-0359. Epub
      2011 May 31.


PMID- 21628050
OWN - NLM
STAT- MEDLINE
DCOM- 20110921
LR  - 20220318
IS  - 1557-9824 (Electronic)
IS  - 0891-5520 (Linking)
VI  - 25
IP  - 2
DP  - 2011 Jun
TI  - Teaching the basics: core competencies in global health.
PG  - 347-58
LID - 10.1016/j.idc.2011.02.013 [doi]
AB  - Compelling moral, ethical, professional, pedagogical, and economic imperatives
      support the integration of global health topics within medical school curriculum.
      Although the process of integrating global health into medical education is well 
      underway at some medical schools, there remain substantial challenges to
      initiating global health training in others. As global health is a new field,
      faculties and schools may benefit from resources and guidance to develop global
      health modules and teaching materials. This article describes the Core
      Competencies project undertaken by the Global Health Education Consortium and the
      Association of Faculties of Medicine of Canada's Global Health Resource Group.
CI  - Copyright (c) 2011. Published by Elsevier Inc.
FAU - Arthur, Megan A M
AU  - Arthur MA
AD  - Global Health Programs, Faculty of Medicine, McGill University, 1020 Pine Avenue 
      West, Montreal, Quebec, Canada.
FAU - Battat, Robert
AU  - Battat R
FAU - Brewer, Timothy F
AU  - Brewer TF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Infect Dis Clin North Am
JT  - Infectious disease clinics of North America
JID - 8804508
SB  - IM
MH  - Curriculum
MH  - *Education, Medical/standards
MH  - Education, Professional
MH  - *Global Health
MH  - Health Policy
MH  - Health Resources/standards
MH  - Human Rights
MH  - Humans
MH  - *International Cooperation
MH  - Professional Competence/*standards
MH  - Schools, Medical/standards
MH  - Teaching
PMC - PMC7135705
EDAT- 2011/06/02 06:00
MHDA- 2011/09/22 06:00
CRDT- 2011/06/02 06:00
PHST- 2011/06/02 06:00 [entrez]
PHST- 2011/06/02 06:00 [pubmed]
PHST- 2011/09/22 06:00 [medline]
AID - S0891-5520(11)00016-X [pii]
AID - 10.1016/j.idc.2011.02.013 [doi]
PST - ppublish
SO  - Infect Dis Clin North Am. 2011 Jun;25(2):347-58. doi: 10.1016/j.idc.2011.02.013.


PMID- 21628046
OWN - NLM
STAT- MEDLINE
DCOM- 20110921
LR  - 20141120
IS  - 1557-9824 (Electronic)
IS  - 0891-5520 (Linking)
VI  - 25
IP  - 2
DP  - 2011 Jun
TI  - Global health: evolving meanings.
PG  - 299-309
LID - 10.1016/j.idc.2011.02.004 [doi]
AB  - Approaches to health, health care, and the terminology to describe global health 
      have evolved over the past 70 years since the introduction of the Constitution of
      the World Health Organization and definition of health in broader terms. The
      early focus on individual care gradually shifted to community, population, and
      global approaches, with associated changes in the site of medical care, the
      personnel who provide it, and the education and training of those personnel.
      Concomitantly, goals changed from purely curative care to disease prevention and 
      health promotion. Health was better understood to exist within the larger
      political, social, cultural, and ethical settings.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Velji, Anvar
AU  - Velji A
AD  - Department of Infectious Disease, Kaiser Permanente, 6600 Bruceville Road, South 
      Sacramento, CA 95823, USA. Anvarali.Velji@kp.org
FAU - Bryant, John H
AU  - Bryant JH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Infect Dis Clin North Am
JT  - Infectious disease clinics of North America
JID - 8804508
SB  - IM
MH  - Delivery of Health Care/*methods/standards
MH  - *Global Health
MH  - *Health Promotion
MH  - *Health Services Accessibility
MH  - *Healthcare Disparities
MH  - Human Rights
MH  - Humans
MH  - International Cooperation
MH  - World Health Organization
EDAT- 2011/06/02 06:00
MHDA- 2011/09/22 06:00
CRDT- 2011/06/02 06:00
PHST- 2011/06/02 06:00 [entrez]
PHST- 2011/06/02 06:00 [pubmed]
PHST- 2011/09/22 06:00 [medline]
AID - S0891-5520(11)00007-9 [pii]
AID - 10.1016/j.idc.2011.02.004 [doi]
PST - ppublish
SO  - Infect Dis Clin North Am. 2011 Jun;25(2):299-309. doi: 10.1016/j.idc.2011.02.004.


PMID- 21628042
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20110601
IS  - 1558-299X (Electronic)
IS  - 0095-4543 (Linking)
VI  - 38
IP  - 2
DP  - 2011 Jun
TI  - Pediatric palliative care.
PG  - 327-61, ix
LID - 10.1016/j.pop.2011.03.011 [doi]
AB  - Progress in pediatric palliative care has gained momentum, but there remain
      significant barriers to the appropriate provision of palliative care to ill and
      dying children, including the lack of properly trained health care professionals,
      resources to finance such care, and scientific research, as well as a continued
      cultural denial of death in children. This article reviews the epidemiology of
      pediatric palliative care, special communication concerns, decision making,
      ethical and legal considerations, symptom assessment and management, psychosocial
      issues, provision of care across settings, end-of-life care, and bereavement.
      Educational and supportive resources for health care practitioners and families, 
      respectively, are included.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Moody, Karen
AU  - Moody K
AD  - Division of Pediatric Hematology/Oncology, Albert Einstein College of Medicine,
      Children's Hospital at Montefiore, 3415 Bainbridge Avenue, 111 East 210th Street,
      Rosenthal 3, Bronx, NY 10463, USA. kmoody@montefiore.org
FAU - Siegel, Linda
AU  - Siegel L
FAU - Scharbach, Kathryn
AU  - Scharbach K
FAU - Cunningham, Leslie
AU  - Cunningham L
FAU - Cantor, Rabbi Mollie
AU  - Cantor RM
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Prim Care
JT  - Primary care
JID - 0430463
SB  - IM
MH  - Advance Care Planning/organization & administration
MH  - Bereavement
MH  - Communication
MH  - Complementary Therapies
MH  - Decision Making
MH  - Humans
MH  - Pain/diagnosis/drug therapy
MH  - Pain Measurement/methods
MH  - Palliative Care/ethics/*organization & administration/psychology
MH  - Parents
MH  - Pediatrics/*organization & administration
MH  - Self-Help Groups
MH  - Terminal Care/ethics/*organization & administration/psychology
EDAT- 2011/06/02 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/06/02 06:00
PHST- 2011/06/02 06:00 [entrez]
PHST- 2011/06/02 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - S0095-4543(11)00024-8 [pii]
AID - 10.1016/j.pop.2011.03.011 [doi]
PST - ppublish
SO  - Prim Care. 2011 Jun;38(2):327-61, ix. doi: 10.1016/j.pop.2011.03.011.


PMID- 21628034
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20110601
IS  - 1558-299X (Electronic)
IS  - 0095-4543 (Linking)
VI  - 38
IP  - 2
DP  - 2011 Jun
TI  - Ethical issues in palliative care.
PG  - 183-93, vii
LID - 10.1016/j.pop.2011.03.003 [doi]
AB  - Ethical problems in medicine are common, especially when caring for patients at
      the end of life. However, many of these issues are not adequately identified in
      the outpatient setting. Primary care providers are in a unique and privileged
      position to identify ethical issues, prevent future conflicts, and help patients 
      make medical decisions that are consistent with their individual values and
      preferences. This article describes some of the more common ethical issues faced 
      by primary care physicians caring for patients with life-limiting illness.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Ko, Danielle N
AU  - Ko DN
AD  - Division of General Internal Medicine, Massachusetts General Hospital, 55 Fruit
      Street, Boston, MA 02114, USA.
FAU - Perez-Cruz, Pedro
AU  - Perez-Cruz P
FAU - Blinderman, Craig D
AU  - Blinderman CD
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Prim Care
JT  - Primary care
JID - 0430463
SB  - IM
MH  - Advance Care Planning
MH  - Decision Making
MH  - Humans
MH  - Pain/drug therapy
MH  - Palliative Care/*ethics
MH  - Terminal Care/*ethics
MH  - Withholding Treatment/ethics
EDAT- 2011/06/02 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/06/02 06:00
PHST- 2011/06/02 06:00 [entrez]
PHST- 2011/06/02 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - S0095-4543(11)00016-9 [pii]
AID - 10.1016/j.pop.2011.03.003 [doi]
PST - ppublish
SO  - Prim Care. 2011 Jun;38(2):183-93, vii. doi: 10.1016/j.pop.2011.03.003.


PMID- 21627812
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20211020
IS  - 1472-6874 (Electronic)
IS  - 1472-6874 (Linking)
VI  - 11
DP  - 2011 May 31
TI  - Assisted reproduction: what factors interfere in the professional's decisions?
      Are single women an issue?
PG  - 21
LID - 10.1186/1472-6874-11-21 [doi]
AB  - BACKGROUND: With the development of medical technology, many countries around the
      world have been implementing ethical guidelines and laws regarding Medically
      Assisted Reproduction (MAR). A physician's reproductive decisions are not solely 
      based on technical criteria but are also influenced by society values. Therefore,
      the aim of this study was to analyze the factors prioritized by MAR professionals
      when deciding on whether to accept to perform assisted reproduction and to show
      any existing cultural differences. METHODS: Cross-sectional study involving 224
      healthcare professionals working with assisted reproduction in Brazil, Italy,
      Germany and Greece. Instrument used for data collection: a questionnaire,
      followed by the description of four special MAR cases (a single woman, a lesbian 
      couple, an HIV discordant couple and gender selection) which included
      case-specific questions regarding the professionals' decision on whether to
      perform the requested procedure as well as the following factors:
      socio-demographic variables, moral and legal values as well as the technical
      aspects which influence decision-making. RESULTS: Only the case involving a
      single woman who wishes to have a child (without the intention of having a
      partner in the future) demonstrated significant differences. Therefore, the study
      was driven towards the results of this case specifically. The analyses we
      performed demonstrated that professionals holding a Master's Degree, those
      younger in age, female professionals, those having worked for less time in
      reproduction, those in private clinics and Brazilian health professionals all had
      a greater tendency to perform the procedure in that case. A multivariate analysis
      demonstrated that the reasons for the professional's decision to perform the
      procedure were the woman's right to gestate and the duty of MAR professionals to 
      help her. The professionals who decided not to perform the procedure identified
      the woman's marital status and the child's right to a father as the reason to
      withhold treatment. CONCLUSION: The study indicates differences among countries
      in the evaluation of the single woman case. It also discloses the undervaluation 
      of bioethics committees and the need for a greater participation of healthcare
      professionals in debates on assisted reproduction laws.
FAU - Zachia, Suzana
AU  - Zachia S
AD  - Post-Graduate Program in Medicine, Assisted Reproduction Service, Gynecology and 
      Obstetrics Department, Hospital de Clinicas de Porto Alegre 90035-903, Porto
      Alegre, Brazil. szachia@hcpa.ufrgs.br
FAU - Knauth, Daniela
AU  - Knauth D
FAU - Goldim, Jose R
AU  - Goldim JR
FAU - Chachamovich, Juliana R
AU  - Chachamovich JR
FAU - Chachamovich, Eduardo
AU  - Chachamovich E
FAU - Paz, Ana H
AU  - Paz AH
FAU - Felberbaum, Ricardo
AU  - Felberbaum R
FAU - Crosignani, PierGiorgio
AU  - Crosignani P
FAU - Tarlatzis, Basil C
AU  - Tarlatzis BC
FAU - Passos, Eduardo P
AU  - Passos EP
LA  - eng
PT  - Journal Article
DEP - 20110531
PL  - England
TA  - BMC Womens Health
JT  - BMC women's health
JID - 101088690
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Biology/ethics
MH  - Brazil
MH  - Cross-Cultural Comparison
MH  - Cross-Sectional Studies
MH  - Decision Making/*ethics
MH  - Female
MH  - Germany
MH  - Greece
MH  - HIV Seronegativity
MH  - HIV Seropositivity
MH  - Homosexuality, Female
MH  - Humans
MH  - Italy
MH  - Male
MH  - Middle Aged
MH  - Physicians/*ethics
MH  - Reproductive Techniques, Assisted/*ethics
MH  - Sex Preselection
MH  - Single Person
PMC - PMC3125239
EDAT- 2011/06/02 06:00
MHDA- 2011/10/25 06:00
CRDT- 2011/06/02 06:00
PHST- 2010/09/22 00:00 [received]
PHST- 2011/05/31 00:00 [accepted]
PHST- 2011/06/02 06:00 [entrez]
PHST- 2011/06/02 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
AID - 1472-6874-11-21 [pii]
AID - 10.1186/1472-6874-11-21 [doi]
PST - epublish
SO  - BMC Womens Health. 2011 May 31;11:21. doi: 10.1186/1472-6874-11-21.


PMID- 21627682
OWN - NLM
STAT- MEDLINE
DCOM- 20120307
LR  - 20111121
IS  - 1365-2648 (Electronic)
IS  - 0309-2402 (Linking)
VI  - 67
IP  - 12
DP  - 2011 Dec
TI  - Relieving existential suffering through palliative sedation: discussion of an
      uneasy practice.
PG  - 2732-40
LID - 10.1111/j.1365-2648.2011.05711.x [doi]
AB  - AIM: This article presents a discussion of the use of palliative sedation in
      response to intractable (not responsive to treatment) existential suffering.
      BACKGROUND: Patients suffering from a terminal illness are often faced with
      severe symptoms at the end of life. Although palliative sedation is sometimes
      used when no other options are effective in relieving unbearable pain or
      suffering, its use in response to intractable existential suffering in terminal
      illness remains controversial. DATA SOURCES: A literature search was conducted
      for published articles addressing the use of palliative sedation between 1996 and
      2009 using established databases. DISCUSSION: Palliative sedation remains an
      uneasy practice. The debates have centred on ethical issues surrounding decisions
      to use sedation and on separating the intent of palliative sedation (relief of
      intolerable symptoms) from the intent of euthanasia (hastening death). There is
      lack of consensus in defining existential suffering. Consequently, there is
      limited understanding of how decisions are being made when using palliative
      sedation to treat intractable existential suffering. CONCLUSIONS: Given the
      confusion and uncertainty about ethical and clinical justifications for
      palliative sedation in treating existential suffering, we argue that a better
      understanding of the controversies and decision-making process is needed. Greater
      understanding is required to prevent palliative sedation from becoming a
      substitute for intensive treatment of this kind of suffering.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Bruce, Anne
AU  - Bruce A
AD  - School of Nursing, University of Victoria, Victoria, British Columbia, Canada.
      abruce@uvic.ca
FAU - Boston, Patricia
AU  - Boston P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110601
PL  - England
TA  - J Adv Nurs
JT  - Journal of advanced nursing
JID - 7609811
RN  - 0 (Hypnotics and Sedatives)
SB  - IM
MH  - Decision Making/ethics
MH  - Deep Sedation/*ethics/methods/statistics & numerical data
MH  - Euthanasia/ethics/statistics & numerical data
MH  - Humans
MH  - Hypnotics and Sedatives/therapeutic use
MH  - Pain Management
MH  - Pain, Intractable/drug therapy
MH  - Palliative Care/*ethics/methods
MH  - Practice Guidelines as Topic
MH  - Stress, Psychological/*drug therapy
MH  - Terminal Care/*ethics/methods
MH  - Terminally Ill/psychology
EDAT- 2011/06/02 06:00
MHDA- 2012/03/08 06:00
CRDT- 2011/06/02 06:00
PHST- 2011/06/02 06:00 [entrez]
PHST- 2011/06/02 06:00 [pubmed]
PHST- 2012/03/08 06:00 [medline]
AID - 10.1111/j.1365-2648.2011.05711.x [doi]
PST - ppublish
SO  - J Adv Nurs. 2011 Dec;67(12):2732-40. doi: 10.1111/j.1365-2648.2011.05711.x. Epub 
      2011 Jun 1.


PMID- 21627615
OWN - NLM
STAT- MEDLINE
DCOM- 20110727
LR  - 20220408
IS  - 0022-9040 (Print)
IS  - 0022-9040 (Linking)
VI  - 51
IP  - 3
DP  - 2011
TI  - [Association of C677T gene polymorphism of methylenetetrahydrofolate reductase
      with insulin resistance among Kirghizes].
PG  - 58-62
AB  - AIM: To study an association of C677T gene polymorphism of
      methylenetetrahydrofolate reductase (MTHFR) and insulin resistance (IR) among
      ethical Kirghizes. METHODS: 132 Kirghiz patients with IR according to HOMA index 
      (n=132) and sex and age matched patients without IR, diabetes mellitus (DM) type 
      2 or metabolic syndrome (MS) (n=132) were included into this study. Measurements 
      of blood pressure (BP), body mass index, waist and hip circumference, fasting
      blood sugar, insulin, lipid parameters and C677T gene polymorphism of MTHFR were 
      performed in all patients. RESULTS: Frequency of CT and TT genotypes was
      significantly higher in patients with IR than in controls (2 - 7.22, p - 0,027,
      OR - 1.68, 95% confidence interval 1.13-2.5, p=0.027). T677 allele was also
      associated with obesity, hypertriglyceridemia and low level of high density
      lipoprotein cholesterol (HDL-C). CONCLUSION: In Kirghizes carriage of T677 allele
      of MTHFR gene was associated with IR, abdominal obesity, hypertriglyceridemia and
      low HDL-C level.
FAU - Lunegova, O S
AU  - Lunegova OS
FAU - Kerimkulova, A S
AU  - Kerimkulova AS
FAU - Turdakmatov, N B
AU  - Turdakmatov NB
FAU - Sovkhozova, N A
AU  - Sovkhozova NA
FAU - Nabiev, M P
AU  - Nabiev MP
FAU - Isakova, Zh T
AU  - Isakova ZhT
FAU - Iusupova, E U
AU  - Iusupova EU
FAU - Moldokeeva, Ch B
AU  - Moldokeeva ChB
FAU - Gotfrid, I Iu
AU  - Gotfrid IIu
FAU - Mirrakhimov, A E
AU  - Mirrakhimov AE
FAU - Aldasheva, N M
AU  - Aldasheva NM
FAU - Kheier, E
AU  - Kheier E
FAU - Aldashev, A A
AU  - Aldashev AA
FAU - Mirrakhimov, E M
AU  - Mirrakhimov EM
LA  - rus
PT  - Journal Article
PL  - Russia (Federation)
TA  - Kardiologiia
JT  - Kardiologiia
JID - 0376351
RN  - 0 (Cholesterol, HDL)
RN  - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2))
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Cholesterol, HDL/*metabolism
MH  - *Diabetes Mellitus, Type 2/epidemiology/genetics
MH  - Female
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease/epidemiology
MH  - Genotype
MH  - Humans
MH  - *Hypertriglyceridemia/epidemiology/etiology/genetics
MH  - Kyrgyzstan/epidemiology
MH  - Male
MH  - *Metabolic Syndrome/epidemiology/genetics
MH  - Methylenetetrahydrofolate Reductase (NADPH2)/*genetics
MH  - Middle Aged
MH  - *Obesity, Abdominal/epidemiology/genetics
MH  - Polymorphism, Genetic
EDAT- 2011/06/02 06:00
MHDA- 2011/07/28 06:00
CRDT- 2011/06/02 06:00
PHST- 2011/06/02 06:00 [entrez]
PHST- 2011/06/02 06:00 [pubmed]
PHST- 2011/07/28 06:00 [medline]
PST - ppublish
SO  - Kardiologiia. 2011;51(3):58-62.


PMID- 21627354
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20220409
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Linking)
VI  - 12
IP  - 3
DP  - 2011
TI  - Prevalence and of smoking and associated factors among Malaysian University
      students.
PG  - 619-24
AB  - OBJECTIVE: The objectives were to determine the prevalence and associated factors
      for smoking among university students in Malaysia. METHODOLOGY: A cross-sectional
      study was conducted among 199 students in the period from December of academic
      year 2009 until April of academic year 2010 in Management and Science University 
      (MSU), Shah Alam, Selangor, Malaysia. The questionnaire was distributed randomly 
      to all faculties of MSU by choosing one of every 3 lecture rooms, as well as the 
      library and cafeterias of the campus randomly by choosing one from every 3
      tables. Questions concerned socio-demographic variables, knowledge, attitudes and
      practice toward smoking. Participant's consent was obtained and ethical approval 
      was provided by the ethics committee of the University. Data entry and analysis
      were performed using descriptive statistics, chi square test, Student t- test and
      logistic multiple regression with the SPSS version 13.0, statistical significance
      being concluded at p < 0.05. RESULTS: About one third of students were smokers
      (29%). The most important reason of smoking was stress (20%) followed by
      'influenced by friends' (16 %). Prevalence of smoking was significantly higher
      among male and those in advanced semesters (p = >0.001, p = 0.047). Smokers had
      low level of knowledge (p < 0.05), had wrong beliefs on smoking (p < 0.05), and
      negative attitude toward tobacco control policies compared to non smokers (p <
      0.05). On multiple logistic regression, significant predictors of smoking in the 
      model were gender (p = 0.025), age (p = 0.037), semester of study (p = 0.025) and
      attitude toward smoking (p < 0.001). CONCLUSION: This study found that 29% of
      university students were smokers. Males and students in advanced semesters were
      more likely to smoke. The results provide baseline data to develop an
      anti-smoking program to limit smoking in the university by implementing policies 
      against smoking.
FAU - Al-Naggar, Redhwan Ahmed
AU  - Al-Naggar RA
AD  - International Medical School, Management and Science University, Shah Alam,
      Malaysia. radhwan888@yahoo.com
FAU - Al-Dubai, Sami Abdo Radman
AU  - Al-Dubai SA
FAU - Al-Naggar, Thekra Hamoud
AU  - Al-Naggar TH
FAU - Chen, Robert
AU  - Chen R
FAU - Al-Jashamy, Karim
AU  - Al-Jashamy K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cross-Sectional Studies
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Malaysia/epidemiology
MH  - Male
MH  - Prevalence
MH  - Smoking/*epidemiology
MH  - Social Environment
MH  - Students/*statistics & numerical data
MH  - Surveys and Questionnaires
MH  - Time Factors
MH  - Universities
MH  - Young Adult
EDAT- 2011/06/02 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/06/02 06:00
PHST- 2011/06/02 06:00 [entrez]
PHST- 2011/06/02 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
PST - ppublish
SO  - Asian Pac J Cancer Prev. 2011;12(3):619-24.


PMID- 21626974
OWN - NLM
STAT- MEDLINE
DCOM- 20110609
LR  - 20191027
IS  - 0256-9574 (Print)
VI  - 101
IP  - 1
DP  - 2011 Jan
TI  - Ethical decision making in severe paediatric burn victims.
PG  - 17-9
FAU - Rode, H
AU  - Rode H
AD  - Red Cross War Memorial Children's Hospital, University of Cape Town.
      heinz.rode@uct.ac.za
FAU - Millar, A J W
AU  - Millar AJ
FAU - Castle, B
AU  - Castle B
FAU - Lyle, J
AU  - Lyle J
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - South Africa
TA  - S Afr Med J
JT  - South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
JID - 0404520
SB  - IM
MH  - Burns/economics/*therapy
MH  - Child
MH  - Decision Making/*ethics
MH  - *Ethics, Medical
MH  - Female
MH  - Humans
MH  - Practice Guidelines as Topic
EDAT- 2011/06/02 06:00
MHDA- 2011/06/10 06:00
CRDT- 2011/06/02 06:00
PHST- 2011/06/02 06:00 [entrez]
PHST- 2011/06/02 06:00 [pubmed]
PHST- 2011/06/10 06:00 [medline]
AID - 10.7196/samj.4250 [doi]
PST - ppublish
SO  - S Afr Med J. 2011 Jan;101(1):17-9. doi: 10.7196/samj.4250.


PMID- 21626892
OWN - NLM
STAT- MEDLINE
DCOM- 20110601
LR  - 20181201
IS  - 1550-7033 (Print)
IS  - 1550-7033 (Linking)
VI  - 7
IP  - 1
DP  - 2011 Feb
TI  - Proceedings of the International Symposium on the Safe Use of Nanomaterials and
      Workshop on Nanomaterial Safety: Status, Procedures and Ethical Concerns.
      February 1-3, 2011. Lucknow, India.
PG  - 1-228
LA  - eng
PT  - Congress
PT  - Overall
PL  - United States
TA  - J Biomed Nanotechnol
JT  - Journal of biomedical nanotechnology
JID - 101230869
SB  - IM
MH  - Animals
MH  - Humans
MH  - *Nanostructures
MH  - Nanotechnology/*ethics/*methods
MH  - *Safety
EDAT- 2011/06/02 06:00
MHDA- 2011/06/02 06:01
CRDT- 2011/06/02 06:00
PHST- 2011/06/02 06:00 [entrez]
PHST- 2011/06/02 06:00 [pubmed]
PHST- 2011/06/02 06:01 [medline]
PST - ppublish
SO  - J Biomed Nanotechnol. 2011 Feb;7(1):1-228.


PMID- 21626879
OWN - NLM
STAT- MEDLINE
DCOM- 20110901
LR  - 20110530
IS  - 0047-1860 (Print)
IS  - 0047-1860 (Linking)
VI  - 59
IP  - 4
DP  - 2011 Apr
TI  - [Ethical issues].
PG  - 383-99
AB  - Key concepts which should be recognized to understand today's medical ethics
      required for information management regarding clinical research are privacy
      protection, use limitation, individual participation, and accountability. Special
      attention should be paid to concepts other than privacy protection, because they 
      are fairly new to medical professionals. Furthermore, in laboratory medicine, we 
      have real problems, for example, how to protect privacy concerning specimens
      gathered from patients. Therefore, there have been many kinds of rules or
      guidelines established recently. Although we tend to strictly follow these
      guidelines, it is not always clear which guidelines should be applied to certain 
      cases, or they do not always exactly correspond to a specific case. The full
      understanding of the principles of medical ethics represented by these guidelines
      is essential. In this paper, a clinical research document reviewed by an ethical 
      review board is shown as an example.
FAU - Nishibori, Masahiro
AU  - Nishibori M
AD  - Department of Social Services and Healthcare Management, International University
      of Health and Welfare, Otawara-shi, Tochigi 324-8501, Japan. mn@iuhw.ac.jp
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Rinsho Byori
JT  - Rinsho byori. The Japanese journal of clinical pathology
JID - 2984781R
SB  - IM
MH  - Biomedical Research
MH  - Codes of Ethics
MH  - Confidentiality
MH  - Ethical Review
MH  - *Ethics, Medical
MH  - Humans
EDAT- 2011/06/02 06:00
MHDA- 2011/09/02 06:00
CRDT- 2011/06/02 06:00
PHST- 2011/06/02 06:00 [entrez]
PHST- 2011/06/02 06:00 [pubmed]
PHST- 2011/09/02 06:00 [medline]
PST - ppublish
SO  - Rinsho Byori. 2011 Apr;59(4):383-99.


PMID- 21626452
OWN - NLM
STAT- MEDLINE
DCOM- 20120207
LR  - 20220321
IS  - 1438-8359 (Electronic)
IS  - 0913-8668 (Linking)
VI  - 25
IP  - 4
DP  - 2011 Aug
TI  - Validation of the Japanese version of the quality of recovery score QoR-40.
PG  - 509-15
LID - 10.1007/s00540-011-1151-2 [doi]
AB  - PURPOSE: The quality of recovery score QoR-40 is a recovery-specific and
      patient-rated questionnaire to assess the early postoperative health status of
      patients. However, the Japanese version of the QoR40 has not been established.
      The aim of this study was to validate the quality of recovery 40 Japanese version
      (the QoR-40J) according to the methods adopted by the International Quality of
      Life Assessment (IQOLA) project. METHODS: After obtaining ethics committee
      approval and consent, 192 general and otological surgical patients were studied. 
      The QoR-40J was used to measure postoperative health status on day 3 and 1 month 
      after surgery. The level of quality of life was also evaluated using a general,
      health-related quality of life questionnaire (Short-Form Health Survey-36
      sub-scales; SF-36), at 1 month after the surgery. Psychometric analysis including
      the following properties: test-retest reliability, internal consistency,
      predictive validity, and measurement of responsiveness, was performed to validate
      the QoR-40J. RESULTS: Test-retest reliability (Spearman's correlation
      coefficient) and internal consistency (Cronbach's alpha) of the QoR-40J were
      0.887 and 0.91, respectively. A significant relationship was observed between the
      total QoR-40J score and duration of hospitalization (r = -0.291) and between the 
      global QoR-40J score and postoperative scores of the SF-36 sub-scales (physical
      function, rho = 0.287; vital score, rho = 0.349). The standardized mean of the
      QoR-40J, a measurement of responsiveness, was 0.70. CONCLUSION: The results of
      the psychometric analysis indicated that the QoR-40J has characteristics of
      acceptable validity, reliability, and responsiveness in clinical practice in
      Japan. The QoR-40J may aid in evaluating the quality of recovery after surgery or
      the quality of methods of anesthesia.
FAU - Tanaka, Yuu
AU  - Tanaka Y
AD  - Department of Anesthesiology, Nara Medical University, 840 Shijo-cho, Kashihara, 
      Nara 634-8522, Japan. tanay6jp@yahoo.co.jp
FAU - Wakita, Takafumi
AU  - Wakita T
FAU - Fukuhara, Shunichi
AU  - Fukuhara S
FAU - Nishiwada, Makoto
AU  - Nishiwada M
FAU - Inoue, Satoki
AU  - Inoue S
FAU - Kawaguchi, Masahiko
AU  - Kawaguchi M
FAU - Furuya, Hitoshi
AU  - Furuya H
LA  - eng
PT  - Journal Article
DEP - 20110531
PL  - Japan
TA  - J Anesth
JT  - Journal of anesthesia
JID - 8905667
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anesthesia/adverse effects
MH  - *Anesthesia Recovery Period
MH  - Female
MH  - Health Status
MH  - Health Surveys
MH  - Humans
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Outcome Assessment, Health Care/*methods
MH  - Postoperative Period
MH  - Psychometrics
MH  - *Quality of Life
MH  - Reproducibility of Results
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2011/06/01 06:00
MHDA- 2012/02/09 06:00
CRDT- 2011/06/01 06:00
PHST- 2010/04/02 00:00 [received]
PHST- 2011/04/11 00:00 [accepted]
PHST- 2011/06/01 06:00 [entrez]
PHST- 2011/06/01 06:00 [pubmed]
PHST- 2012/02/09 06:00 [medline]
AID - 10.1007/s00540-011-1151-2 [doi]
PST - ppublish
SO  - J Anesth. 2011 Aug;25(4):509-15. doi: 10.1007/s00540-011-1151-2. Epub 2011 May
      31.


PMID- 21626382
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20160707
IS  - 1437-1588 (Electronic)
IS  - 1436-9990 (Linking)
VI  - 54
IP  - 6
DP  - 2011 Jun
TI  - [Report of the Central Ethics Committee for Stem Cell Research (ZES) : eighth
      report after the enactment of the Stem Cell Act (StZG), Reporting Period: 1
      December 2009 to 31 December 2010].
PG  - 760-5
LID - 10.1007/s00103-011-1279-0 [doi]
LA  - ger
PT  - Journal Article
TT  - Tatigkeitsbericht der Zentralen Ethik-Kommission fur Stammzellenforschung (ZES) :
      Achter Bericht nach Inkrafttreten des Stammzellgesetzes (StZG) fur den Zeitraum
      vom 01.12.2009 bis 31.12.2010.
PL  - Germany
TA  - Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
JT  - Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
JID - 101181368
SB  - IM
MH  - Germany
MH  - *Government Regulation
MH  - Stem Cell Research/*ethics/*legislation & jurisprudence
EDAT- 2011/06/01 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/06/01 06:00
PHST- 2011/06/01 06:00 [entrez]
PHST- 2011/06/01 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/s00103-011-1279-0 [doi]
PST - ppublish
SO  - Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2011
      Jun;54(6):760-5. doi: 10.1007/s00103-011-1279-0.


PMID- 21626363
OWN - NLM
STAT- MEDLINE
DCOM- 20120123
LR  - 20211020
IS  - 1432-1084 (Electronic)
IS  - 0938-7994 (Linking)
VI  - 21
IP  - 10
DP  - 2011 Oct
TI  - Patient acceptability of CT colonography compared with double contrast barium
      enema: results from a multicentre randomised controlled trial of symptomatic
      patients.
PG  - 2046-55
LID - 10.1007/s00330-011-2154-y [doi]
AB  - OBJECTIVES: To determine patient acceptability of barium enema (BE) or CT
      colonography (CTC). METHODS: After ethical approval, 921 consenting patients with
      symptoms suggestive of colorectal cancer who had been randomly assigned and
      completed either BE (N = 606) or CTC (N = 315) received a questionnaire to assess
      experience of the clinical episode including bowel preparation, procedure and
      complications. Satisfaction, worry and physical discomfort were assessed using an
      adapted version of a validated acceptability scale. Non-parametric methods
      assessed differences between the randomised tests and the effect of patient
      characteristics. RESULTS: Patients undergoing BE were significantly less
      satisfied (median 61, interquartile range [IQR] 54-67 vs. median 64, IQR 56-69; p
      = 0.003) and experienced more physical discomfort (median 40, IQR 29-52 vs.
      median 35.5, IQR 25-47; p < 0.001) than those undergoing CTC. Post-test, BE
      patients were significantly more likely to experience 'abdominal pain/cramps'
      (68% vs. 57%; p = 0.007), 'soreness' (57% vs. 37%; p < 0.001), 'nausea/vomiting' 
      (16% vs. 8%; p = 0.009), 'soiling' (31% vs. 23%; p = 0.034) and 'wind' (92% vs.
      84%; p = 0.001) and in the case of 'wind' to also rate it as severe (27% vs. 15%;
      p < 0.001). CONCLUSION: CTC is associated with significant improvements in
      patient experience. These data support the case for CTC to replace BE.
FAU - von Wagner, Christian
AU  - von Wagner C
AD  - Department of Epidemiology and Public Health, University College London, London, 
      UK.
FAU - Smith, Samuel
AU  - Smith S
FAU - Halligan, Steve
AU  - Halligan S
FAU - Ghanouni, Alex
AU  - Ghanouni A
FAU - Power, Emily
AU  - Power E
FAU - Lilford, Richard J
AU  - Lilford RJ
FAU - Morton, Dion
AU  - Morton D
FAU - Dadswell, Edward
AU  - Dadswell E
FAU - Atkin, Wendy
AU  - Atkin W
FAU - Wardle, Jane
AU  - Wardle J
CN  - SIGGAR Investigators
LA  - eng
GR  - 02/02/01/DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110531
PL  - Germany
TA  - Eur Radiol
JT  - European radiology
JID - 9114774
RN  - 0 (Contrast Media)
RN  - 24GP945V5T (Barium)
SB  - IM
CIN - Nat Rev Clin Oncol. 2013 May;10(5):254-5. PMID: 23546516
MH  - Abdominal Pain
MH  - Aged
MH  - *Barium
MH  - Choice Behavior
MH  - Colonic Neoplasms/*diagnosis
MH  - Colonography, Computed Tomographic/*methods
MH  - Colonoscopy/*methods
MH  - Contrast Media/*pharmacology
MH  - Enema/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Patient Satisfaction
MH  - Reproducibility of Results
MH  - Surveys and Questionnaires
IR  - Dadswell E
FIR - Dadswell, E
IR  - Kanani R
FIR - Kanani, R
IR  - Wooldrage K
FIR - Wooldrage, K
IR  - Rogers P
FIR - Rogers, P
IR  - Edwards R
FIR - Edwards, Rob
IR  - Shah U
FIR - Shah, U
IR  - Kralj-Hans I
FIR - Kralj-Hans, I
IR  - Ghanouni A
FIR - Ghanouni, A
IR  - Pack K
FIR - Pack, K
IR  - Waddingham J
FIR - Waddingham, J
IR  - Thomson A
FIR - Thomson, A
IR  - Verjee A
FIR - Verjee, A
IR  - Monk C
FIR - Monk, C
IR  - Kanani R
FIR - Kanani, R
IR  - Dadswell E
FIR - Dadswell, E
IR  - Ghanouni A
FIR - Ghanouni, A
IR  - Muckian J
FIR - Muckian, J
IR  - Gibbons N
FIR - Gibbons, N
IR  - Bastable D
FIR - Bastable, D
IR  - Coni L
FIR - Coni, L
IR  - Martin J
FIR - Martin, J
IR  - Stephenson S
FIR - Stephenson, S
IR  - Jackson C
FIR - Jackson, C
IR  - Wormald A
FIR - Wormald, A
IR  - Beech D
FIR - Beech, D
IR  - Lynn C
FIR - Lynn, C
IR  - Bloor C
FIR - Bloor, C
IR  - Wilkinson S
FIR - Wilkinson, S
IR  - Pickles L
FIR - Pickles, L
IR  - Scothern J
FIR - Scothern, J
IR  - Hennedy A
FIR - Hennedy, A
IR  - Larkin T
FIR - Larkin, T
IR  - Pearson P
FIR - Pearson, P
IR  - Preston S
FIR - Preston, S
IR  - Smith L
FIR - Smith, L
IR  - Wright L
FIR - Wright, L
IR  - Blackstock J
FIR - Blackstock, J
IR  - Thomas R
FIR - Thomas, R
IR  - Young L
FIR - Young, L
IR  - Butler-Barnes J
FIR - Butler-Barnes, J
IR  - Adamson V
FIR - Adamson, V
IR  - Larcombe T
FIR - Larcombe, T
IR  - Bradshaw V
FIR - Bradshaw, V
IR  - Chapman S
FIR - Chapman, S
IR  - Slater M
FIR - Slater, M
IR  - Stylan J
FIR - Stylan, J
IR  - Wood D
FIR - Wood, D
IR  - Bradbury J
FIR - Bradbury, J
IR  - Breedon J
FIR - Breedon, J
IR  - Coakes M
FIR - Coakes, M
IR  - Crutch L
FIR - Crutch, L
IR  - Leyland A
FIR - Leyland, A
IR  - Pringle W
FIR - Pringle, W
IR  - Rowe L
FIR - Rowe, L
IR  - White M
FIR - White, M
IR  - Worley A
FIR - Worley, A
IR  - Kumar D
FIR - Kumar, D
IR  - Gandy M
FIR - Gandy, M
IR  - Pascoe J
FIR - Pascoe, J
IR  - Wood J
FIR - Wood, J
IR  - Cook W
FIR - Cook, W
IR  - Memory Y
FIR - Memory, Y
IR  - Avery M
FIR - Avery, M
IR  - Pearson K
FIR - Pearson, K
IR  - Shivapatham D
FIR - Shivapatham, D
IR  - Thomas S
FIR - Thomas, S
IR  - Ong C
FIR - Ong, C
IR  - Poppinga-Scholz B
FIR - Poppinga-Scholz, B
IR  - Shanahan B
FIR - Shanahan, B
IR  - Turner L
FIR - Turner, L
IR  - Fellows K
FIR - Fellows, K
IR  - Duffy A
FIR - Duffy, A
IR  - Owen A
FIR - Owen, A
IR  - Usansky A
FIR - Usansky, A
IR  - Naim F
FIR - Naim, F
IR  - Bohra V
FIR - Bohra, V
IR  - Prabhudesai S
FIR - Prabhudesai, S
IR  - Hayes M
FIR - Hayes, M
IR  - Lancelotte N
FIR - Lancelotte, N
IR  - James T
FIR - James, T
IR  - Johnston S
FIR - Johnston, S
IR  - Stevenson J
FIR - Stevenson, J
IR  - Whetter D
FIR - Whetter, D
IR  - Bartram C
FIR - Bartram, C
IR  - Burling D
FIR - Burling, D
IR  - Gupta A
FIR - Gupta, A
IR  - Halligan S
FIR - Halligan, S
IR  - Marshall M
FIR - Marshall, M
IR  - Taylor SA
FIR - Taylor, S A
IR  - Higginson A
FIR - Higginson, A
IR  - Atchley J
FIR - Atchley, J
IR  - Kay C
FIR - Kay, C
IR  - Lowe A
FIR - Lowe, A
IR  - Maskell GF
FIR - Maskell, G F
IR  - Taylor A
FIR - Taylor, A
IR  - Tan E
FIR - Tan, E
IR  - McGregor J
FIR - McGregor, J
IR  - Hayward S
FIR - Hayward, S
IR  - Philips A
FIR - Philips, A
IR  - Noakes M
FIR - Noakes, M
IR  - Zaman S
FIR - Zaman, S
IR  - Guest P
FIR - Guest, P
IR  - McCafferty I
FIR - McCafferty, I
IR  - Riley P
FIR - Riley, P
IR  - Tattersall D
FIR - Tattersall, D
IR  - Jobling C
FIR - Jobling, C
IR  - Dhingsa R
FIR - Dhingsa, R
IR  - Jackson SA
FIR - Jackson, S A
IR  - Fox BM
FIR - Fox, B M
IR  - Shirley J
FIR - Shirley, J
IR  - Kumar M
FIR - Kumar, M
IR  - Blunt D
FIR - Blunt, D
IR  - Roddie M
FIR - Roddie, M
IR  - Slater A
FIR - Slater, A
IR  - Sukumar SA
FIR - Sukumar, S A
IR  - Hughes N
FIR - Hughes, N
IR  - Woolfall P
FIR - Woolfall, P
IR  - Saunders B
FIR - Saunders, B
IR  - Northover JM
FIR - Northover, J M A
IR  - Goggin P
FIR - Goggin, P
IR  - O'Leary D
FIR - O'Leary, D
IR  - Ausobsky MJ
FIR - Ausobsky, Mr J
IR  - Beckett C
FIR - Beckett, C
IR  - Davies J
FIR - Davies, J
IR  - Griffith J
FIR - Griffith, J
IR  - Steward M
FIR - Steward, M
IR  - Crighton I
FIR - Crighton, I
IR  - Bronder C
FIR - Bronder, C
IR  - Brown C
FIR - Brown, C
IR  - Higham A
FIR - Higham, A
IR  - Lea R
FIR - Lea, R
IR  - Meaden C
FIR - Meaden, C
IR  - Morgan W
FIR - Morgan, W
IR  - Patel P
FIR - Patel, P
IR  - Nasmyth G
FIR - Nasmyth, G
IR  - Williamson M
FIR - Williamson, M
IR  - Cade D
FIR - Cade, D
IR  - Morton D
FIR - Morton, D
IR  - Scholefield J
FIR - Scholefield, J
IR  - Hosie K
FIR - Hosie, K
IR  - Whitehead E
FIR - Whitehead, E
IR  - Conlong P
FIR - Conlong, P
IR  - Rameh B
FIR - Rameh, B
IR  - Rate A
FIR - Rate, A
IR  - Richards D
FIR - Richards, D
IR  - Bansi D
FIR - Bansi, D
IR  - Buchanan G
FIR - Buchanan, G
IR  - Dawson P
FIR - Dawson, P
IR  - Martin J
FIR - Martin, J
IR  - Smith G
FIR - Smith, G
IR  - Theodorou NA
FIR - Theodorou, N A
IR  - Thillainayagam A
FIR - Thillainayagam, A
IR  - Cunningham C
FIR - Cunningham, C
IR  - Travis S
FIR - Travis, S
IR  - Hyde GM
FIR - Hyde, G M
IR  - Jones DJ
FIR - Jones, D J
IR  - O'Dwyer ST
FIR - O'Dwyer, S T
IR  - Ziprin P
FIR - Ziprin, P
IR  - Edwards CD
FIR - Edwards, Col D
IR  - Burton S
FIR - Burton, S
IR  - Fabricius P
FIR - Fabricius, P
IR  - Gudgeon M
FIR - Gudgeon, M
IR  - Jourdan I
FIR - Jourdan, I
IR  - Rutter M
FIR - Rutter, M
IR  - Altman DG
FIR - Altman, D G
IR  - Steele R
FIR - Steele, R
IR  - Walker A
FIR - Walker, A
IR  - Dixon A
FIR - Dixon, A
IR  - Foulds-Wood L
FIR - Foulds-Wood, L
IR  - Marteau T
FIR - Marteau, T
IR  - Valori R
FIR - Valori, R
EDAT- 2011/06/01 06:00
MHDA- 2012/01/24 06:00
CRDT- 2011/06/01 06:00
PHST- 2011/02/15 00:00 [received]
PHST- 2011/04/29 00:00 [accepted]
PHST- 2011/03/31 00:00 [revised]
PHST- 2011/06/01 06:00 [entrez]
PHST- 2011/06/01 06:00 [pubmed]
PHST- 2012/01/24 06:00 [medline]
AID - 10.1007/s00330-011-2154-y [doi]
PST - ppublish
SO  - Eur Radiol. 2011 Oct;21(10):2046-55. doi: 10.1007/s00330-011-2154-y. Epub 2011
      May 31.


PMID- 21626219
OWN - NLM
STAT- MEDLINE
DCOM- 20131122
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 18
IP  - 4
DP  - 2012 Dec
TI  - More education, less administration: reflections of neuroimagers' attitudes to
      ethics through the qualitative looking glass.
PG  - 775-88
LID - 10.1007/s11948-011-9282-2 [doi]
AB  - In follow-up to a large-scale ethics survey of neuroscientists whose research
      involves neuroimaging, brain stimulation and imaging genetics, we conducted focus
      groups and interviews to explore their sense of responsibility about integrating 
      ethics into neuroimaging and readiness to adopt new ethics strategies as part of 
      their research. Safety, trust and virtue were key motivators for incorporating
      ethics into neuroimaging research. Managing incidental findings emerged as a
      predominant daily challenge for faculty, while student reports focused on the
      malleability of neuroimaging data and scientific integrity. The most frequently
      cited barrier was time and administrative burden associated with the ethics
      review process. Lack of scholarly training in ethics also emerged as a major
      barrier. Participants constructively offered remedies to these challenges:
      development and dissemination of best practices and standardized ethics review
      for minimally invasive neuroimaging protocols. Students in particular, urged
      changes to curricula to include early, focused training in ethics.
FAU - Kehagia, A A
AU  - Kehagia AA
AD  - National Core for Neuroethics, Division of Neurology, Department of Medicine, The
      University of British Columbia, 2211 Wesbrook Mall, Koerner S124, Vancouver, BC, 
      V6T 2B5, Canada. angie.kehagia@gmail.com
FAU - Tairyan, K
AU  - Tairyan K
FAU - Federico, C
AU  - Federico C
FAU - Glover, G H
AU  - Glover GH
FAU - Illes, J
AU  - Illes J
LA  - eng
GR  - 9R01MH84282/MH/NIMH NIH HHS/United States
GR  - CNE 85117/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110528
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Biomedical Research/*ethics
MH  - Curriculum
MH  - Diagnostic Imaging/*ethics
MH  - *Ethics, Research/education
MH  - Focus Groups
MH  - Humans
MH  - Interviews as Topic
MH  - Motivation
MH  - Organization and Administration
EDAT- 2011/06/01 06:00
MHDA- 2013/12/16 06:00
CRDT- 2011/06/01 06:00
PHST- 2010/12/31 00:00 [received]
PHST- 2011/05/15 00:00 [accepted]
PHST- 2011/06/01 06:00 [entrez]
PHST- 2011/06/01 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1007/s11948-011-9282-2 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2012 Dec;18(4):775-88. doi: 10.1007/s11948-011-9282-2. Epub 2011 
      May 28.


PMID- 21625827
OWN - NLM
STAT- MEDLINE
DCOM- 20110920
LR  - 20191112
IS  - 1868-8551 (Electronic)
IS  - 1868-596X (Linking)
VI  - 28
IP  - 2
DP  - 2011
TI  - Systematic review of chimpanzee use in monoclonal antibody research and drug
      development: 1981-2010.
PG  - 103-16
AB  - This survey examines the extent to which live chimpanzees have been used in
      monoclonal antibody (mAb) research and the drug approval process. The survey
      covers 193 scientific articles published during the years 1981-2010, as well as
      preclinical studies leading to the approval of mAb drugs by the Food and Drug
      Administration of the United States. The frequency of the articles has decreased 
      by more than two- thirds from their highs in the late 1980's, and the aggregate
      number of chimpanzees used in these studies has decreased by more than 90%. The
      experimental protocols ranged from single or multiple blood draws to extraction
      of body fluids and tissue samples, and to multiple, repeated organ biopsies. Many
      studies involved infecting the chimpanzee(s) with pathogenic organisms and
      immunization and infusion protocols. Addressing the health history and status of 
      the chimpanzees was an exception rather than the rule, and anesthesia and
      analgesia were mentioned only in a small minority of the surveyed articles. In
      the past two decades, the FDA has approved 32 mAb drugs, but only three of those 
      drugs could be determined to involve the chimpanzee in the preclinical stage. Two
      of those three drugs have been withdrawn from the market due to their severe
      adverse effects in human patients. Available alternatives, together with ethical 
      and economic reasons, suggest that the use of the chimpanzee in this manner may
      not be necessary or appropriate.
FAU - Bettauer, Raija H
AU  - Bettauer RH
AD  - Bettauer BioMed Research, McLean, VA, USA. raija.bettauer@verizon.net
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
PT  - Systematic Review
PL  - Germany
TA  - ALTEX
JT  - ALTEX
JID - 100953980
RN  - 0 (Antibodies, Monoclonal)
SB  - IM
MH  - *Animal Testing Alternatives
MH  - Animal Welfare
MH  - Animals
MH  - Antibodies, Monoclonal/*pharmacology
MH  - *Pan troglodytes
MH  - *Research Design
EDAT- 2011/06/01 06:00
MHDA- 2011/09/21 06:00
CRDT- 2011/06/01 06:00
PHST- 2011/06/01 06:00 [entrez]
PHST- 2011/06/01 06:00 [pubmed]
PHST- 2011/09/21 06:00 [medline]
AID - 10.14573/altex.2011.2.103 [doi]
PST - ppublish
SO  - ALTEX. 2011;28(2):103-16. doi: 10.14573/altex.2011.2.103.


PMID- 21625741
OWN - NLM
STAT- MEDLINE
DCOM- 20111122
LR  - 20220317
IS  - 1678-7765 (Electronic)
IS  - 1678-7757 (Linking)
VI  - 19
IP  - 3
DP  - 2011 May-Jun
TI  - Validation of an experimental polyurethane model for biomechanical studies on
      implant supported prosthesis--tension tests.
PG  - 244-8
LID - S1678-77572011000300012 [pii]
AB  - OBJECTIVES: The complexity and heterogeneity of human bone, as well as ethical
      issues, frequently hinder the development of clinical trials. The purpose of this
      in vitro study was to determine the modulus of elasticity of a polyurethane
      isotropic experimental model via tension tests, comparing the results to those
      reported in the literature for mandibular bone, in order to validate the use of
      such a model in lieu of mandibular bone in biomechanical studies. MATERIAL AND
      METHODS: Forty-five polyurethane test specimens were divided into 3 groups of 15 
      specimens each, according to the ratio (A/B) of polyurethane reagents (PU-1:
      1/0.5, PU-2: 1/1, PU-3: 1/1.5). RESULTS: Tension tests were performed in each
      experimental group and the modulus of elasticity values found were 192.98 MPa
      (SD=57.20) for PU-1, 347.90 MPa (SD=109.54) for PU-2 and 304.64 MPa (SD=25.48)
      for PU-3. CONCLUSION: The concentration of choice for building the experimental
      model was 1/1.
FAU - Miyashiro, Mariane
AU  - Miyashiro M
AD  - Bauru School of Dentistry, University of Sao Paulo, Bauru, SP, Brazil.
FAU - Suedam, Valdey
AU  - Suedam V
FAU - Moretti Neto, Rafael Tobias
AU  - Moretti Neto RT
FAU - Ferreira, Paulo Martins
AU  - Ferreira PM
FAU - Rubo, Jose Henrique
AU  - Rubo JH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
PL  - Brazil
TA  - J Appl Oral Sci
JT  - Journal of applied oral science : revista FOB
JID - 101189774
RN  - 0 (Dental Implants)
RN  - 0 (Polyurethanes)
SB  - IM
MH  - Analysis of Variance
MH  - Biomechanical Phenomena
MH  - *Dental Implants
MH  - Dental Prosthesis, Implant-Supported/*methods
MH  - *Elastic Modulus
MH  - Humans
MH  - Materials Testing
MH  - Models, Theoretical
MH  - Polyurethanes/*chemistry
MH  - Tensile Strength
PMC - PMC4234337
EDAT- 2011/06/01 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/06/01 06:00
PHST- 2009/07/01 00:00 [received]
PHST- 2010/05/25 00:00 [accepted]
PHST- 2011/06/01 06:00 [entrez]
PHST- 2011/06/01 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S1678-77572011000300012 [pii]
AID - 10.1590/s1678-77572011000300012 [doi]
PST - ppublish
SO  - J Appl Oral Sci. 2011 May-Jun;19(3):244-8. doi: 10.1590/s1678-77572011000300012.


PMID- 21625670
OWN - NLM
STAT- MEDLINE
DCOM- 20110922
LR  - 20151119
IS  - 1172-6156 (Electronic)
IS  - 1172-6156 (Linking)
VI  - 3
IP  - 2
DP  - 2011 Jun 1
TI  - Medical ethics: four principles, two decisions, two roles and no reasons.
PG  - 170-4
AB  - The 'four principle' view of medical ethics has a strong international pedigree. 
      Despite wide acceptance, there is controversy about the meaning and use of the
      principles in clinical practice as a checklist for moral behaviour. Recent
      attempts by medical regulatory authorities to use the four principles to judge
      medical practitioner behaviour have not met with success in clarifying how these 
      principles can be incorporated into a legal framework. This may reflect the
      philosophical debate about the relationship between law and morals. In this
      paper, legal decisions from two cases in which general practitioners have been
      charged with professional shortcomings are discussed. Difficulties with the
      application of the four principles (autonomy, beneficence, nonmaleficence and
      justice) to judge medical practitioner behaviour are highlighted. The four
      principles are relevant to medical practitioner behaviour, but if applied as
      justifications for disciplinary decisions without explanation, perverse results
      may ensue. Solutions are suggested to minimise ambiguities in the application of 
      the four principles: adjudicators should acknowledge the difference between
      professional and common morality and the statutory requirement to give decisions 
      with reasons.
FAU - Kennelly, John
AU  - Kennelly J
AD  - Department of General Practice and Primary Health Care, The University of
      Auckland, PB 92019, Auckland, New Zealand. j.kennelly@auckland.ac.nz
LA  - eng
PT  - Journal Article
DEP - 20110601
PL  - Australia
TA  - J Prim Health Care
JT  - Journal of primary health care
JID - 101524060
SB  - IM
CIN - J Prim Health Care. 2011 Sep;3(3):254. PMID: 21892437
MH  - Beneficence
MH  - *Ethics, Medical
MH  - Female
MH  - General Practice/*ethics
MH  - Humans
MH  - Male
MH  - *Morals
MH  - New Zealand
MH  - Personal Autonomy
MH  - Physician's Role
MH  - Physician-Patient Relations/*ethics
MH  - Practice Patterns, Physicians'/*ethics/legislation & jurisprudence
MH  - Social Justice
EDAT- 2011/06/01 06:00
MHDA- 2011/09/23 06:00
CRDT- 2011/06/01 06:00
PHST- 2011/06/01 06:00 [entrez]
PHST- 2011/06/01 06:00 [pubmed]
PHST- 2011/09/23 06:00 [medline]
PST - epublish
SO  - J Prim Health Care. 2011 Jun 1;3(2):170-4.


PMID- 21625629
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20220318
IS  - 1662-5145 (Electronic)
IS  - 1662-5145 (Linking)
VI  - 5
DP  - 2011
TI  - Ethical issues in deep brain stimulation.
PG  - 17
LID - 10.3389/fnint.2011.00017 [doi]
AB  - Deep brain stimulation (DBS) is currently used to treat neurological disorders
      like Parkinson's disease, essential tremor, and dystonia, and is explored as an
      experimental treatment for psychiatric disorders like major depression and
      obsessive compulsive disorder. This mini review discusses ethical issues in DBS
      treatment and research, as they have been discussed in the medical and ethical
      literature. With regard to DBS treatment, the most important issues are balancing
      risks and benefits and ensuring respect for the autonomous wish of the patient.
      This implies special attention to patient selection, psycho-social impact of
      treatment, effects on personal identity, and treatment of children. Moreover, it 
      implies a careful informed consent process in which unrealistic expectations of
      patients and their families are addressed and in which special attention is given
      to competence. In the context of research, the fundamental ethical challenge is
      to promote high-quality scientific research in the interest of future patients,
      while at the same time safeguarding the rights and interests of vulnerable
      research subjects. Several guidelines have been proposed to ensure this. One of
      the preconditions to further development of responsible and transparent research 
      practices is the establishment of a comprehensive registry.
FAU - Schermer, Maartje
AU  - Schermer M
AD  - Department of Medical Ethics and Philosophy, Erasmus University Medical Center
      Rotterdam, Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20110509
PL  - Switzerland
TA  - Front Integr Neurosci
JT  - Frontiers in integrative neuroscience
JID - 101477950
PMC - PMC3096836
OTO - NOTNLM
OT  - bioethics
OT  - deep brain stimulation
OT  - medical ethics
OT  - neuro-psychiatric disorders
OT  - neuroethics
OT  - neuromodulation
OT  - psychosurgery
OT  - research ethics
EDAT- 2011/06/01 06:00
MHDA- 2011/06/01 06:01
CRDT- 2011/06/01 06:00
PHST- 2010/12/14 00:00 [received]
PHST- 2011/04/26 00:00 [accepted]
PHST- 2011/06/01 06:00 [entrez]
PHST- 2011/06/01 06:00 [pubmed]
PHST- 2011/06/01 06:01 [medline]
AID - 10.3389/fnint.2011.00017 [doi]
PST - epublish
SO  - Front Integr Neurosci. 2011 May 9;5:17. doi: 10.3389/fnint.2011.00017.
      eCollection 2011.


PMID- 21625325
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 1176-7529 (Print)
IS  - 1176-7529 (Linking)
VI  - 8
IP  - 1
DP  - 2011 Mar 1
TI  - Psychiatric molecular genetics and the ethics of social promises.
PG  - 27-34
AB  - A recent literature review of commentaries and 'state of the art' articles from
      researchers in psychiatric genetics (PMG) offers a consensus about progress in
      the science of genetics, disappointments in the discovery of new and effective
      treatments, and a general optimism about the future of the field. I argue that
      optimism for the field of psychiatric molecular genetics (PMG) is overwrought,
      and consider progress in the field in reference to a sample estimate of US
      National Institute of Mental Health funding for this paradigm for the years 2008 
      and 2009. I conclude that the amounts of financial investment in PMG is
      questionable from an ethical perspective, given other research and clinical needs
      in the USA.
FAU - Sadler, John Z
AU  - Sadler JZ
AD  - Departments of Psychiatry & Clinical Sciences, Program in Ethics in Science &
      Medicine, The University of Texas Southwestern Medical Center, 5323 Harry Hines
      Boulevard, Dallas, TX 75390-9070.
FAU - Foster, Daniel W
AU  - Foster DW
LA  - eng
GR  - UL1 RR024982-02/RR/NCRR NIH HHS/United States
PT  - Journal Article
PL  - Netherlands
TA  - J Bioeth Inq
JT  - Journal of bioethical inquiry
JID - 101250741
PMC - PMC3102532
MID - NIHMS291851
EDAT- 2011/06/01 06:00
MHDA- 2011/06/01 06:01
CRDT- 2011/06/01 06:00
PHST- 2011/06/01 06:00 [entrez]
PHST- 2011/06/01 06:00 [pubmed]
PHST- 2011/06/01 06:01 [medline]
AID - 10.1007/s11673-010-9273-z [doi]
PST - ppublish
SO  - J Bioeth Inq. 2011 Mar 1;8(1):27-34. doi: 10.1007/s11673-010-9273-z.


PMID- 21625117
OWN - NLM
STAT- MEDLINE
DCOM- 20111019
LR  - 20190710
IS  - 1662-2782 (Electronic)
IS  - 0302-5144 (Linking)
VI  - 171
DP  - 2011
TI  - Current technological approaches for a wearable artificial kidney.
PG  - 231-236
LID - 10.1159/000327335 [doi]
AB  - A wearable artificial kidney (WAK) is a device that continuously supports renal
      function during ambulation or social activities out of hospital. With the aim of 
      improving dialysis patients' quality of life, WAK systems have been in
      development for several decades. Technological evolutions in dialysis membrane
      and dialysate regeneration have been paving the way to wearability, and the
      possibility of implantation, for renal replacement therapies. However, at
      present, there are many technical issues confronting the attempts to apply WAK
      systems in clinical practice. Here, we have reviewed the necessary technical
      requirements and the WAKs currently being developed that are trying to meet
      these. Aside from technical issues, ethical, legal and economic aspects should be
      also considered together, in order to minimize trial and error in the development
      of the WAK. Continuous follow- up, integration with emerging new technologies,
      and multidisciplinary approaches involving clinicians, engineers, economists and 
      social scientists are required for the realization of WAK in clinical practice.
CI  - Copyright (c) 2011 S. Karger AG, Basel.
FAU - Kim, Jeong Chul
AU  - Kim JC
FAU - Ronco, Claudio
AU  - Ronco C
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110523
PL  - Switzerland
TA  - Contrib Nephrol
JT  - Contributions to nephrology
JID - 7513582
SB  - IM
MH  - Humans
MH  - *Kidneys, Artificial
EDAT- 2011/06/01 06:00
MHDA- 2011/10/20 06:00
CRDT- 2011/06/01 06:00
PHST- 2011/06/01 06:00 [entrez]
PHST- 2011/06/01 06:00 [pubmed]
PHST- 2011/10/20 06:00 [medline]
AID - 000327335 [pii]
AID - 10.1159/000327335 [doi]
PST - ppublish
SO  - Contrib Nephrol. 2011;171:231-236. doi: 10.1159/000327335. Epub 2011 May 23.


PMID- 21624881
OWN - NLM
STAT- MEDLINE
DCOM- 20110809
LR  - 20211020
IS  - 1098-4275 (Electronic)
IS  - 0031-4005 (Linking)
VI  - 127
IP  - 6
DP  - 2011 Jun
TI  - Parents' decisions to screen newborns for FMR1 gene expansions in a pilot
      research project.
PG  - e1455-63
LID - 10.1542/peds.2010-3078 [doi]
AB  - OBJECTIVE: The goal of this study was to document rates of parental consent in a 
      pilot study of newborn screening for FMR1 gene expansions, examine demographic
      characteristics of mothers who consented or declined, describe the reasons for
      their decision, and discuss ethical and social aspects of the consent process.
      METHODS: A brief survey was used to record basic demographic data from mothers
      and an open-ended question was used to elicit parents' reasons for accepting or
      declining screening. A descriptive analysis was conducted on the number of
      mothers who consented to or declined screening, and a logistic regression model
      predicted mothers' likelihood to agree to screening based on demographic
      characteristics. Reasons for decisions were analyzed using content analysis. The 
      study was conducted at University of North Carolina Hospitals. A total of 2137
      mothers were approached. RESULTS: The uptake rate for couples was 63%. Acceptance
      rates varied by race/ethnicity, with black respondents being less likely to
      accept screening. Primary reasons for accepting were "to know," "belief in
      research," and "the test was minimal/no risk." Reasons for declining included not
      wanting to know or worry, not being a good time, and issues with testing children
      or with genetic tests. CONCLUSIONS: Findings demonstrate that a majority of
      parents accepted newborn screening for FMR1 gene expansions, but decision rates
      and reasons for accepting or declining varied in part as a function of
      race/ethnicity and in part as a function of what parents most valued or feared in
      their assessment of risks and benefits.
FAU - Skinner, Debra
AU  - Skinner D
AD  - FPG Child Development Institute, University of North Carolina at Chapel Hill,
      Carrboro, NC 27510, USA. debra.skinner@unc.edu
FAU - Choudhury, Summer
AU  - Choudhury S
FAU - Sideris, John
AU  - Sideris J
FAU - Guarda, Sonia
AU  - Guarda S
FAU - Buansi, Allen
AU  - Buansi A
FAU - Roche, Myra
AU  - Roche M
FAU - Powell, Cynthia
AU  - Powell C
FAU - Bailey, Donald B Jr
AU  - Bailey DB Jr
LA  - eng
GR  - P50 HG004488/HG/NHGRI NIH HHS/United States
GR  - P30 HD003110-S1/HD/NICHD NIH HHS/United States
GR  - P30 HD003110/HD/NICHD NIH HHS/United States
GR  - 5P50HG004488/HG/NHGRI NIH HHS/United States
GR  - U32-MC00148/PHS HHS/United States
GR  - UL1RR025747/RR/NCRR NIH HHS/United States
GR  - UL1 RR025747/RR/NCRR NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20110529
PL  - United States
TA  - Pediatrics
JT  - Pediatrics
JID - 0376422
RN  - 0 (FMR1 protein, human)
RN  - 139135-51-6 (Fragile X Mental Retardation Protein)
SB  - IM
MH  - Adult
MH  - *Decision Making
MH  - Female
MH  - Fragile X Mental Retardation Protein/*analysis
MH  - Fragile X Syndrome/*diagnosis/genetics
MH  - Genetic Testing/*psychology
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - Parental Consent/ethics/*psychology
MH  - Parents/*psychology
MH  - Pilot Projects
MH  - Retrospective Studies
PMC - PMC3103273
EDAT- 2011/06/01 06:00
MHDA- 2011/08/10 06:00
CRDT- 2011/06/01 06:00
PHST- 2011/06/01 06:00 [entrez]
PHST- 2011/06/01 06:00 [pubmed]
PHST- 2011/08/10 06:00 [medline]
AID - peds.2010-3078 [pii]
AID - 10.1542/peds.2010-3078 [doi]
PST - ppublish
SO  - Pediatrics. 2011 Jun;127(6):e1455-63. doi: 10.1542/peds.2010-3078. Epub 2011 May 
      29.


PMID- 21624805
OWN - NLM
STAT- MEDLINE
DCOM- 20120301
LR  - 20211020
IS  - 1875-9777 (Electronic)
IS  - 1875-9777 (Linking)
VI  - 8
IP  - 6
DP  - 2011 Jun 3
TI  - Researching the relationships between tissue providers, clinicians, and stem cell
      scientists.
PG  - 613-5
LID - 10.1016/j.stem.2011.05.005 [doi]
AB  - Access to human reproductive tissue is essential for many forms of stem cell
      research. We identify questions for future studies of tissue providers,
      procurers, and end-user scientists, and suggest that international comparative
      studies of all three parties, and of the relationships between them, will improve
      the ethical supply of tissue.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Haimes, Erica
AU  - Haimes E
AD  - Policy Ethics and Life Sciences (PEALS) Research Centre, Newcastle University,
      Fourth Floor, Claremont Bridge, Newcastle upon Tyne, NE1 7RU, UK.
      erica.haimes@newcastle.ac.uk
FAU - Taylor, Ken
AU  - Taylor K
LA  - eng
GR  - G0701109/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PL  - United States
TA  - Cell Stem Cell
JT  - Cell stem cell
JID - 101311472
SB  - IM
MH  - Humans
MH  - *Physicians
MH  - *Research Personnel
MH  - *Stem Cell Research
MH  - Stem Cells
MH  - *Tissue Donors
EDAT- 2011/06/01 06:00
MHDA- 2012/03/02 06:00
CRDT- 2011/06/01 06:00
PHST- 2011/06/01 06:00 [entrez]
PHST- 2011/06/01 06:00 [pubmed]
PHST- 2012/03/02 06:00 [medline]
AID - S1934-5909(11)00227-X [pii]
AID - 10.1016/j.stem.2011.05.005 [doi]
PST - ppublish
SO  - Cell Stem Cell. 2011 Jun 3;8(6):613-5. doi: 10.1016/j.stem.2011.05.005.


PMID- 21624702
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20181201
IS  - 1097-6760 (Electronic)
IS  - 0196-0644 (Linking)
VI  - 58
IP  - 3
DP  - 2011 Sep
TI  - A window on professionalism in the emergency department through medical student
      narratives.
PG  - 288-94
LID - 10.1016/j.annemergmed.2011.04.001 [doi]
AB  - STUDY OBJECTIVE: We use medical students' reflections to deepen understanding of 
      professionalism in the emergency department (ED), including the ideals that
      students wish to model and the lapses they hope to avoid. METHODS: Fourth-year
      students in a mandatory ED clerkship were required to write 2 narrative
      reflections during the month. The authors conducted a qualitative analysis to
      determine professionalism themes. RESULTS: Sixty-one of 150 student reflections
      contained professionalism themes. Positive behaviors included compassion, tension
      between respecting diversity and respecting other core values, and balance
      between patient-centered care and effective care. In addition, the students wrote
      about commitment to excellent medical care and ethical principles. Many students 
      struggled with how to deal with patients who might be "drug seekers" and when to 
      prescribe narcotics. They were concerned about the balance of compassion, often
      noting differences in the patients' backgrounds compared with their own. On the
      other hand, many students observed unprofessional behaviors. Particularly
      concerning were the absence of compassion, physicians lying, and a lack of
      teamwork. Students reflected on how their own professional behavior could improve
      according to their experiences in the ED. CONCLUSION: Students' reflective
      narratives are a rich source of information about good professional behavior, as 
      well as threats to professionalism. Their experiences shaped the students'
      perceptions of emergency medicine and its values. Such reflections may constitute
      an important resource for faculty, student, and resident development.
CI  - Copyright (c) 2011 American College of Emergency Physicians. Published by Mosby, 
      Inc. All rights reserved.
FAU - Santen, Sally A
AU  - Santen SA
AD  - Office of Medical Education and Student Affairs, Emory School of Medicine,
      Atlanta, GA 30322, USA. ssanten@emory.edu
FAU - Hemphill, Robin R
AU  - Hemphill RR
LA  - eng
PT  - Journal Article
DEP - 20110531
PL  - United States
TA  - Ann Emerg Med
JT  - Annals of emergency medicine
JID - 8002646
SB  - IM
MH  - Clinical Clerkship
MH  - *Clinical Competence
MH  - Cross-Sectional Studies
MH  - Emergency Service, Hospital/*standards
MH  - Humans
MH  - Physician-Patient Relations
MH  - Quality of Health Care/standards
MH  - Social Values
MH  - *Students, Medical
MH  - Workforce
EDAT- 2011/06/01 06:00
MHDA- 2011/11/09 06:00
CRDT- 2011/06/01 06:00
PHST- 2011/02/05 00:00 [received]
PHST- 2011/03/28 00:00 [revised]
PHST- 2011/04/04 00:00 [accepted]
PHST- 2011/06/01 06:00 [entrez]
PHST- 2011/06/01 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - S0196-0644(11)00353-2 [pii]
AID - 10.1016/j.annemergmed.2011.04.001 [doi]
PST - ppublish
SO  - Ann Emerg Med. 2011 Sep;58(3):288-94. doi: 10.1016/j.annemergmed.2011.04.001.
      Epub 2011 May 31.


PMID- 21624697
OWN - NLM
STAT- MEDLINE
DCOM- 20111017
LR  - 20110531
IS  - 1558-3481 (Electronic)
IS  - 0899-5885 (Linking)
VI  - 23
IP  - 2
DP  - 2011 Jun
TI  - Ethical considerations in pediatric critical care research.
PG  - 377-84
LID - 10.1016/j.ccell.2011.04.005 [doi]
AB  - Pediatric critical care nurses are exposed to research in the critical care
      environment on a routine basis and should be knowledgeable about the ethical
      considerations inherent in this process. The following discussion includes
      information that centers on the ethical issues of conducting research with
      children. First, children as a vulnerable population is explored, followed by
      selected ethical principles that pertain to research, the role of the
      technological imperative in research, the process of informed consent, and
      finally, nursing considerations.
CI  - Copyright (c) 2011. Published by Elsevier Inc.
FAU - Zeigler, Vicki L
AU  - Zeigler VL
AD  - College of Nursing, Texas Woman's University, Denton, TX 76204-5498, USA.
      vzeigler@twu.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Crit Care Nurs Clin North Am
JT  - Critical care nursing clinics of North America
JID - 8912620
MH  - Child
MH  - Critical Care/*ethics
MH  - Humans
MH  - Informed Consent/ethics
MH  - Intensive Care Units, Pediatric/ethics
MH  - Pediatric Nursing/*ethics
MH  - Therapeutic Human Experimentation/ethics
EDAT- 2011/06/01 06:00
MHDA- 2011/10/18 06:00
CRDT- 2011/06/01 06:00
PHST- 2011/06/01 06:00 [entrez]
PHST- 2011/06/01 06:00 [pubmed]
PHST- 2011/10/18 06:00 [medline]
AID - S0899-5885(11)00011-6 [pii]
AID - 10.1016/j.ccell.2011.04.005 [doi]
PST - ppublish
SO  - Crit Care Nurs Clin North Am. 2011 Jun;23(2):377-84. doi:
      10.1016/j.ccell.2011.04.005.


PMID- 21624678
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20110531
IS  - 1526-3231 (Electronic)
IS  - 0749-8063 (Linking)
VI  - 27
IP  - 6
DP  - 2011 Jun
TI  - Bacterial adherence to high--tensile strength sutures.
PG  - 834-8
LID - 10.1016/j.arthro.2011.02.003 [doi]
AB  - PURPOSE: The purpose of this study was to evaluate the bacterial adherence to
      high--tensile strength suture materials using a bioluminescent in vitro model.
      METHODS: Eleven strands each of No. 2 MaxBraid (Arthrotek [Biomet], Warsaw, IN), 
      FiberWire (Arthrex, Naples, FL), Ethibond (Ethicon, Somerville, NJ), Orthocord
      (DePuy Mitek, Raynham, MA), and silk (Ethicon) sutures were immersed in a broth
      of bioluminescent Staphylococcus aureus, which is genetically engineered to emit 
      photons. After 12 hours in the broth, the suture strands were individually
      irrigated with 10 mL of low-pressure normal saline solution and imaged with a
      photon-capturing camera system that yields a total photon count that correlates
      directly with residual bacterial counts. RESULTS: MaxBraid had the greatest
      adherence, followed by FiberWire, Ethibond, Orthocord, and silk. Orthocord had
      only 25% of the bacterial adherence of MaxBraid (P < .001). Ethibond and
      FiberWire had 53% (P < .001) and 75% (P = .003) of the adherence of MaxBraid,
      respectively. Differences between each suture were also statistically
      significant, with Ethibond and Orthocord having 71% (P = .007) and 33% (P < .001)
      of the adherence of FiberWire, respectively, and Orthocord having 47% (P < .001) 
      of the adherence of Ethibond. The adherence to silk was statistically lower than 
      all of the high-tensile strength sutures. CONCLUSIONS: Among high--tensile
      strength sutures, Orthocord has significantly less bacterial adherence than
      MaxBraid and FiberWire. Although infections in arthroscopic shoulder surgery are 
      rare, the physical properties of surgical implants should be known by surgeons.
      In addition, bacterial adherence may contribute to suture selection in a patient 
      prone to infection or to the use of suture in other body areas at greater risk
      for contamination. CLINICAL RELEVANCE: Bacterial adherence to high--tensile
      strength sutures may be a useful factor in implant selection in a patient with
      predisposition for contamination or infection.
CI  - Published by Elsevier Inc.
FAU - Masini, Brendan D
AU  - Masini BD
AD  - Brooke Army Medical Center, Fort Sam Houston, TX 78234, USA.
      Brendan.Masini@amedd.army.mil
FAU - Stinner, Daniel J
AU  - Stinner DJ
FAU - Waterman, Scott M
AU  - Waterman SM
FAU - Wenke, Joseph C
AU  - Wenke JC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Arthroscopy
JT  - Arthroscopy : the journal of arthroscopic & related surgery : official
      publication of the Arthroscopy Association of North America and the International
      Arthroscopy Association
JID - 8506498
SB  - IM
MH  - Bacterial Adhesion/*physiology
MH  - Colony Count, Microbial
MH  - Humans
MH  - Materials Testing/*methods
MH  - Staphylococcus aureus/*physiology
MH  - Surgical Wound Infection/microbiology/prevention & control
MH  - Sutures/*microbiology
MH  - *Tensile Strength
EDAT- 2011/06/01 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/06/01 06:00
PHST- 2010/04/13 00:00 [received]
PHST- 2011/01/21 00:00 [revised]
PHST- 2011/02/04 00:00 [accepted]
PHST- 2011/06/01 06:00 [entrez]
PHST- 2011/06/01 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0749-8063(11)00125-3 [pii]
AID - 10.1016/j.arthro.2011.02.003 [doi]
PST - ppublish
SO  - Arthroscopy. 2011 Jun;27(6):834-8. doi: 10.1016/j.arthro.2011.02.003.


PMID- 21624455
OWN - NLM
STAT- MEDLINE
DCOM- 20111202
LR  - 20110803
IS  - 1879-3177 (Electronic)
IS  - 0887-2333 (Linking)
VI  - 25
IP  - 6
DP  - 2011 Sep
TI  - A discussion of the impact of US chemical regulation legislation on the field of 
      toxicity testing.
PG  - 1231-6
LID - 10.1016/j.tiv.2011.05.005 [doi]
AB  - Proposals for revising the principal United States law governing industrial
      chemicals, the Toxic Substances Control Act, have been under consideration in the
      US Congress for the past several years, and some version of such legislation may 
      be passed in the near future. Concurrently, a desire to move away from current
      testing methods for ethical, scientific, and practical reasons has led to
      multi-million dollar investments in in vitro and computational toxicology methods
      and programs. Legislative language has the potential to endorse this transition
      and facilitate its fruition, or conversely enshrine in vivo testing methods for
      the foreseeable future. New legislation also has the potential to substantially
      increase the numbers of animals used in toxicity tests in the near term. However,
      there are a number of policies that, used effectively, can reduce the overall
      number of animals used in new toxicity tests. We present recent legislative
      proposals in the context of current testing programs and discuss their potential 
      impacts on animal use, test method innovation, and achievement of desired
      legislative objectives. Discussions like these are essential to judiciously
      select policies that reduce the use of animals in toxicity testing and protect
      human health and the environment.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Sullivan, Kristie
AU  - Sullivan K
AD  - Physicians Committee for Responsible Medicine, Washington, DC 20016, USA.
      ksullivan@pcrm.org
FAU - Beck, Nancy
AU  - Beck N
FAU - Sandusky, Chad
AU  - Sandusky C
FAU - Willett, Catherine
AU  - Willett C
LA  - eng
PT  - Journal Article
DEP - 20110523
PL  - England
TA  - Toxicol In Vitro
JT  - Toxicology in vitro : an international journal published in association with
      BIBRA
JID - 8712158
RN  - 0 (Hazardous Substances)
SB  - IM
MH  - Animal Testing Alternatives/legislation & jurisprudence
MH  - Animal Welfare/legislation & jurisprudence
MH  - Animals
MH  - Computational Biology/methods
MH  - Hazardous Substances/*toxicity
MH  - Humans
MH  - Industry
MH  - Toxicity Tests/*methods
MH  - Toxicology/*legislation & jurisprudence
MH  - United States
EDAT- 2011/06/01 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/06/01 06:00
PHST- 2010/09/13 00:00 [received]
PHST- 2011/04/27 00:00 [revised]
PHST- 2011/05/03 00:00 [accepted]
PHST- 2011/06/01 06:00 [entrez]
PHST- 2011/06/01 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0887-2333(11)00130-5 [pii]
AID - 10.1016/j.tiv.2011.05.005 [doi]
PST - ppublish
SO  - Toxicol In Vitro. 2011 Sep;25(6):1231-6. doi: 10.1016/j.tiv.2011.05.005. Epub
      2011 May 23.


PMID- 21623703
OWN - NLM
STAT- MEDLINE
DCOM- 20120604
LR  - 20131106
IS  - 1744-7682 (Electronic)
IS  - 1471-2598 (Linking)
VI  - 11
IP  - 10
DP  - 2011 Oct
TI  - Fetal gene therapy: recent advances and current challenges.
PG  - 1257-71
LID - 10.1517/14712598.2011.585153 [doi]
AB  - INTRODUCTION: Fetal gene therapy (FGT) can potentially be applied to perinatally 
      lethal monogenic diseases for rescuing clinically severe phenotypes, increasing
      the probability of intact neurological and other key functions at birth, or
      inducing immune tolerance to a transgenic protein to facilitate readministration 
      of the vector/protein postnatally. As the field is still at an experimental
      stage, there are several important considerations regarding the practicality and 
      the ethics of FGT. AREAS COVERED: Here, through a review of FGT studies, the
      authors discuss the role and applications of FGT, the progress made with animal
      models that simulate human development, possible adverse effects in the recipient
      fetus and the mother and factors that affect clinical translation. EXPERT
      OPINION: Although there are valid safety and ethical concerns, the authors argue 
      that there may soon be enough convincing evidence from non-human primate models
      to take the next step towards clinical trials in the near future.
CI  - (c) 2011 Informa UK, Ltd.
FAU - Mattar, Citra N
AU  - Mattar CN
AD  - Yong Loo Lin School of Medicine, National University of Singapore, Department of 
      Obstetrics and Gynaecology, Experimental Fetal Medicine Group, NUHS Tower Block, 
      Level 12, 1E Kent Ridge Road, 119228 Singapore.
FAU - Choolani, Mahesh
AU  - Choolani M
FAU - Biswas, Arijit
AU  - Biswas A
FAU - Waddington, Simon N
AU  - Waddington SN
FAU - Chan, Jerry K Y
AU  - Chan JK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110531
PL  - England
TA  - Expert Opin Biol Ther
JT  - Expert opinion on biological therapy
JID - 101125414
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - Female
MH  - Fetal Diseases/*genetics/*therapy
MH  - Fetal Therapies/*methods/*trends
MH  - Genetic Therapy/*methods/*trends
MH  - Genetic Vectors/administration & dosage/genetics
MH  - Germ Cells/immunology
MH  - Humans
MH  - Pregnancy
EDAT- 2011/06/01 06:00
MHDA- 2012/06/05 06:00
CRDT- 2011/06/01 06:00
PHST- 2011/06/01 06:00 [entrez]
PHST- 2011/06/01 06:00 [pubmed]
PHST- 2012/06/05 06:00 [medline]
AID - 10.1517/14712598.2011.585153 [doi]
PST - ppublish
SO  - Expert Opin Biol Ther. 2011 Oct;11(10):1257-71. doi:
      10.1517/14712598.2011.585153. Epub 2011 May 31.


PMID- 21623646
OWN - NLM
STAT- MEDLINE
DCOM- 20110920
LR  - 20211020
IS  - 1179-2000 (Electronic)
IS  - 1177-1062 (Linking)
VI  - 15
IP  - 2
DP  - 2011 Apr 1
TI  - Attitudes of health care professionals toward pharmacogenetic testing.
PG  - 115-22
LID - 10.2165/11589490-000000000-00000 [doi]
AB  - BACKGROUND: Pharmacogenetics has emerged as a new tool for the optimization of
      drug therapy. Although the pharmacogenetics concept was first recognized at least
      50 years ago, clinical testing to determine pharmacogenetic traits is still
      relatively rare, and many hurdles are markedly slowing its development. There is 
      a lot of literature and speculation about potential ethical challenges in genetic
      and pharmacogenetic testing, yet few researchers have actually examined the
      attitudes of health care professionals regarding the clinical application of
      these tests. OBJECTIVE: In this article, we aim to review the current literature 
      on health care professionals' perceptions of the role of pharmacogenetic data and
      describe the attitudes of medical students when faced with a clinical
      pharmacogenetic testing scenario. METHODS: A group of 59 third-year medical
      students from the American University of Beirut Medical Center were asked to
      answer a questionnaire about pharmacogenetic testing after being exposed to a
      clinical scenario of a patient who was diagnosed with mild Alzheimer Disease (AD)
      and hence was a candidate for therapy with one of the acetylcholinesterase (AChE)
      inhibitors. RESULTS: The students indicated that they would respect patients'
      confidentiality and inform them about the test results and therapeutic plan, but 
      they would not be as open about bad prognoses. They did not agree on the
      therapeutic plan that would follow a pharmacogenetic test result and were
      uncertain about potential patient discrimination in insurability. CONCLUSION: Our
      and others' findings demonstrate the existence and seriousness of several
      challenges pertaining to pharmacogenetic applications in the clinical setting.
      Further training and education are needed for health care professionals, since
      they are the ones who will most probably request these tests in the near future.
FAU - Zgheib, Nathalie K
AU  - Zgheib NK
AD  - Department of Pharmacology Toxicology, American University of Beirut, Lebanon.
FAU - Arawi, Thalia
AU  - Arawi T
FAU - Mahfouz, Rami A
AU  - Mahfouz RA
FAU - Sabra, Ramzi
AU  - Sabra R
LA  - eng
PT  - Journal Article
PT  - Review
PL  - New Zealand
TA  - Mol Diagn Ther
JT  - Molecular diagnosis & therapy
JID - 101264260
SB  - IM
MH  - Confidentiality/ethics/legislation & jurisprudence
MH  - *Health Knowledge, Attitudes, Practice
MH  - Health Personnel/*psychology
MH  - Humans
MH  - Informed Consent
MH  - *Pharmacogenetics/ethics/legislation & jurisprudence
MH  - Students, Medical/psychology
MH  - Surveys and Questionnaires
EDAT- 2011/06/01 06:00
MHDA- 2011/09/21 06:00
CRDT- 2011/06/01 06:00
PHST- 2011/06/01 06:00 [entrez]
PHST- 2011/06/01 06:00 [pubmed]
PHST- 2011/09/21 06:00 [medline]
AID - 3 [pii]
AID - 10.1007/BF03256401 [doi]
PST - ppublish
SO  - Mol Diagn Ther. 2011 Apr 1;15(2):115-22. doi: 10.1007/BF03256401.


PMID- 31051854
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1876-7982 (Electronic)
IS  - 1876-7982 (Linking)
VI  - 42
IP  - 2
DP  - 2011 Jun
TI  - Human Papillomavirus-related Oropharyngeal Carcinoma: Current Understanding and
      Enduring Uncertainties.
PG  - 86-94
LID - S1939-8654(11)00004-X [pii]
LID - 10.1016/j.jmir.2011.02.002 [doi]
AB  - The etiological role of high risk human papillomavirus (HPV) has been widely
      accepted in carcinomas of cervix, but this has only recently been confirmed in a 
      subset of oropharyngeal carcinomas (OPC). The HPV-related OPC has now been
      clinically differentiated from the classic smoking/drinking-related OPC, and is
      considered a distinct molecular and clinical entity. This literature review aims 
      to provide a summary of the current understanding and enduring uncertainties in
      the field of HPV-related OPC, specifically related to: the natural history and
      carcinogenic effect of HPV infection, the clinicopathology and treatment response
      of HPV-related OPC, and broader HPV-related social and medico-ethical issues.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Huang, Shao Hui
AU  - Huang SH
AD  - University of Toronto/Princess Margaret Hospital, Toronto, Ontario, Canada.
      Electronic address: Shaohui.Huang@rmp.uhn.on.ca.
FAU - Rosewall, Tara
AU  - Rosewall T
AD  - University of Toronto/Princess Margaret Hospital, Toronto, Ontario, Canada.
LA  - eng
PT  - Journal Article
DEP - 20110530
PL  - United States
TA  - J Med Imaging Radiat Sci
JT  - Journal of medical imaging and radiation sciences
JID - 101469694
EDAT- 2011/06/01 00:00
MHDA- 2011/06/01 00:01
CRDT- 2019/05/05 06:00
PHST- 2010/08/04 00:00 [received]
PHST- 2011/01/21 00:00 [revised]
PHST- 2011/02/07 00:00 [accepted]
PHST- 2019/05/05 06:00 [entrez]
PHST- 2011/06/01 00:00 [pubmed]
PHST- 2011/06/01 00:01 [medline]
AID - S1939-8654(11)00004-X [pii]
AID - 10.1016/j.jmir.2011.02.002 [doi]
PST - ppublish
SO  - J Med Imaging Radiat Sci. 2011 Jun;42(2):86-94. doi: 10.1016/j.jmir.2011.02.002. 
      Epub 2011 May 30.


PMID- 31051851
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1876-7982 (Electronic)
IS  - 1876-7982 (Linking)
VI  - 42
IP  - 2
DP  - 2011 Jun
TI  - The Impact of Evolving Image-Guidance Processes on Initial Patient Setup for Lung
      Radiotherapy.
PG  - 66-73
LID - S1939-8654(11)00018-X [pii]
LID - 10.1016/j.jmir.2011.02.003 [doi]
AB  - PURPOSE: The purpose of this study was to investigate whether the implementation 
      of three different daily image-guidance processes has altered initial
      (pre-imaging) patient setup practice for thoracic radiotherapy patients. METHODS:
      A total of 1 997 daily cone-beam computed tomography (CBCT) images from 72
      thoracic patients undergoing radical radiotherapy were retrospectively reviewed
      under ethics approval. Patients were analyzed in three consecutive cohorts
      grouped according to the image-guidance process used during radiotherapy. After
      initial alignment of skin marks and lasers: Process A (24 patients spanning 6
      months), CBCT alignment with an action level of 3 mm, correction applied via
      manual couch adjustment, followed by a verification CBCT; Process B (22 patients,
      5 months), CBCT alignment with an action level of 3 mm, correction applied via
      remote couch adjustment, followed by a verification CBCT; Process C (26 patients,
      5 months), CBCT alignment with correction applied for all displacements via
      remote couch adjustment, with no verification scans required. Initial patient
      setup displacements from skin marks were determined by re-registering the initial
      alignment CBCT to the planning CT using automated spine matching. Patient setup
      displacements were compared between the three processes in the left-right (LR),
      cranial-caudal (CC), and anterior-posterior (AP) directions. RESULTS: The mean
      +/- 1 standard deviation of initial patient setup displacements were calculated
      for each cohort: Process A, 1.2 +/- 2.4 mm (LR), 0.6 +/- 3.5 mm (CC), and -0.8
      +/- 2.0 mm (AP); Process B, 0.5 +/- 2.7 mm (LR), 1.2 +/- 3.4 mm (CC) and -1.7 +/-
      2.0 mm (AP); Process C, 1.0 +/- 2.5 mm (LR), 0.1 +/- 3.5 mm (CC), and -2.3 +/-
      2.2 mm (AP). The means systematic and random uncertainties were comparable
      between the processes, showing similar setup error distributions. CONCLUSION:
      Initial skin setup practices for thoracic radiotherapy patients remain unaffected
      across the three image-guidance processes. Pre-imaging alignment principles and
      performance by radiation therapists at our center remain consistent amid
      technological advances.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Li, Winnie
AU  - Li W
AD  - Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada;
      Department of Radiation Oncology, University of Toronto, Toronto, Ontario,
      Canada. Electronic address: Winnie.Li@rmp.uhn.on.ca.
FAU - Moseley, Douglas J
AU  - Moseley DJ
AD  - Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada;
      Department of Radiation Oncology, University of Toronto, Toronto, Ontario,
      Canada.
FAU - Craig, Tim
AU  - Craig T
AD  - Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada;
      Department of Radiation Oncology, University of Toronto, Toronto, Ontario,
      Canada.
FAU - Bezjak, Andrea
AU  - Bezjak A
AD  - Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada;
      Department of Radiation Oncology, University of Toronto, Toronto, Ontario,
      Canada.
FAU - Jaffray, David A
AU  - Jaffray DA
AD  - Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada;
      Department of Radiation Oncology, University of Toronto, Toronto, Ontario,
      Canada; Department of Medical Biophysics, University of Toronto, Toronto,
      Ontario, Canada.
LA  - eng
PT  - Journal Article
DEP - 20110530
PL  - United States
TA  - J Med Imaging Radiat Sci
JT  - Journal of medical imaging and radiation sciences
JID - 101469694
EDAT- 2011/06/01 00:00
MHDA- 2011/06/01 00:01
CRDT- 2019/05/05 06:00
PHST- 2010/12/17 00:00 [received]
PHST- 2011/02/12 00:00 [revised]
PHST- 2011/02/16 00:00 [accepted]
PHST- 2019/05/05 06:00 [entrez]
PHST- 2011/06/01 00:00 [pubmed]
PHST- 2011/06/01 00:01 [medline]
AID - S1939-8654(11)00018-X [pii]
AID - 10.1016/j.jmir.2011.02.003 [doi]
PST - ppublish
SO  - J Med Imaging Radiat Sci. 2011 Jun;42(2):66-73. doi: 10.1016/j.jmir.2011.02.003. 
      Epub 2011 May 30.


PMID- 30200039
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 2051-6967 (Electronic)
IS  - 0790-9667 (Linking)
VI  - 28
IP  - 2
DP  - 2011 Jun
TI  - Informed consent in psychiatric practice: where does the law now stand?
PG  - 86-90
LID - 10.1017/S0790966700011502 [doi]
AB  - There is an established ethical and legal duty upon psychiatrists to obtain
      informed consent before treating a patient, although some exceptions do apply
      under Mental Health Legislation. The required standard for informed consent has
      been the subject of important case law in Ireland and other common law
      jurisdictions and this has caused some uncertainty for clinicians. The standard
      of informed consent can be viewed from the point of view of what the medical
      profession thinks is appropriate, or alternatively from the position of what a
      patient would reasonably expect to be told. These contrasting approaches are
      discussed in detail. A recent decision of the Irish Supreme Court establishes the
      'patient-centred' standard for informed consent as the relevant standard in Irish
      law. The current legal position on informed consent is discussed in relation to
      common clinical scenarios in psychiatric practice.
FAU - Leonard, Peter
AU  - Leonard P
AD  - St Joseph's Intellectual Disability Service,St Ita's Hospital,Portrane,Co.
      Dublin,Ireland.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Ir J Psychol Med
JT  - Irish journal of psychological medicine
JID - 8900208
EDAT- 2011/06/01 00:00
MHDA- 2011/06/01 00:01
CRDT- 2018/09/12 06:00
PHST- 2018/09/12 06:00 [entrez]
PHST- 2011/06/01 00:00 [pubmed]
PHST- 2011/06/01 00:01 [medline]
AID - S0790966700011502 [pii]
AID - 10.1017/S0790966700011502 [doi]
PST - ppublish
SO  - Ir J Psychol Med. 2011 Jun;28(2):86-90. doi: 10.1017/S0790966700011502.


PMID- 25812558
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150328
LR  - 20220210
IS  - 2005-727X (Print)
IS  - 2005-727X (Linking)
VI  - 23
IP  - 2
DP  - 2011 Jun
TI  - Implementation of the medical research curriculum in graduate medical school.
PG  - 103-10
LID - 10.3946/kjme.2011.23.2.103 [doi]
AB  - PURPOSE: The purpose of this study was to analyze the effect of the medical
      research curriculum on the students' satisfaction and the research self-efficacy.
      METHODS: The curriculum was implemented to 79 graduate medical school students
      who entered in 2007 and 2008. This curriculum is implemented through 3 years
      consisting of 5 different sub-courses: Research design, Research ethics, Medical 
      statistics, Writing medical paper, and Presentation. The effect of this program
      was measured with 2 self-administered surveys to students: the course
      satisfaction survey and the self-efficacy inventories. The Research Self-Efficacy
      Scale consisted of 18 items from 4 categories: Research design, Research ethics, 
      Data analysis, and Result presentation. The descriptive statistics, paired
      t-test, and analysis of covariance (ANCOVA) were implemented. RESULTS: The
      average point of satisfaction of the course was 2.74 out of 4, which told us that
      students generally satisfied with the course. The frequencies of tutoring for
      research course were 2 or 3 times on average and each session of tutorial lasted 
      1.5 to 2 hours. The research self-efficacy in three categories (Research design, 
      Research ethics, and Result presentation) increased significantly (p<0.1). The
      self-efficacy of the male students was higher than females' one. The
      self-efficacy was not significantly different by the experience of research paper
      writing at undergraduate level. CONCLUSION: The curriculum showed positive
      results in cultivating research self-efficacy of students. There is a need for
      improvement of the class of Statistical analysis as students reported that it was
      difficult.
FAU - Park, Kwi Hwa
AU  - Park KH
AD  - Department of Medical Education, Gachon University of Medicine and Science School
      of Medicine, Incheon, Korea.
FAU - Kim, Tae-Hee
AU  - Kim TH
AD  - Department of Medical Education, Gachon University of Medicine and Science School
      of Medicine, Incheon, Korea.
FAU - Chung, Wook-Jin
AU  - Chung WJ
AD  - Department of Medical Education, Gachon University of Medicine and Science School
      of Medicine, Incheon, Korea.
LA  - eng
PT  - Journal Article
DEP - 20110630
PL  - Korea (South)
TA  - Korean J Med Educ
JT  - Korean journal of medical education
JID - 101503071
PMC - PMC8814498
OTO - NOTNLM
OT  - Biomedical research
OT  - Curriculum
OT  - Graduate medical education
OT  - Medical students
OT  - Self efficacy
EDAT- 2011/06/01 00:00
MHDA- 2011/06/01 00:01
CRDT- 2015/03/28 06:00
PHST- 2010/12/15 00:00 [received]
PHST- 2011/04/07 00:00 [accepted]
PHST- 2015/03/28 06:00 [entrez]
PHST- 2011/06/01 00:00 [pubmed]
PHST- 2011/06/01 00:01 [medline]
AID - kjme.2011.23.2.103 [pii]
AID - 10.3946/kjme.2011.23.2.103 [doi]
PST - ppublish
SO  - Korean J Med Educ. 2011 Jun;23(2):103-10. doi: 10.3946/kjme.2011.23.2.103. Epub
      2011 Jun 30.


PMID- 24846263
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140522
LR  - 20160511
IS  - 1947-5535 (Print)
IS  - 1947-5543 (Linking)
VI  - 9
IP  - 2
DP  - 2011 Jun
TI  - Patients' and citizens' points of view.
PG  - 169-74
LID - 10.1089/bio.2010.0030 [doi]
AB  - In this article, the first section introduces general considerations on the
      opinions of patients and the public regarding biobanks. The notion of "public
      opinion" is briefly described and discussed in a historical perspective. The
      second section illustrates the results of some surveys carried out in the United 
      States and Europe regarding biobanks. Finally, patients' and citizens' opinions
      on the storage and use of biological samples are discussed within an ethical
      framework of principles and values. Four main aspects are discussed: willingness 
      to participate in research; preferences and the perception of norms; language;
      and opportunities and limits of deliberative democracy in political decisions
      about biobanking.
FAU - Petrini, Carlo
AU  - Petrini C
AD  - Istituto Superiore di Sanita (Italian National Institute of Health) , Rome, Italy
      .
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Biopreserv Biobank
JT  - Biopreservation and biobanking
JID - 101507284
EDAT- 2011/06/01 00:00
MHDA- 2011/06/01 00:01
CRDT- 2014/05/22 06:00
PHST- 2014/05/22 06:00 [entrez]
PHST- 2011/06/01 00:00 [pubmed]
PHST- 2011/06/01 00:01 [medline]
AID - 10.1089/bio.2010.0030 [doi]
PST - ppublish
SO  - Biopreserv Biobank. 2011 Jun;9(2):169-74. doi: 10.1089/bio.2010.0030.


PMID- 24846262
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140522
LR  - 20160511
IS  - 1947-5535 (Print)
IS  - 1947-5543 (Linking)
VI  - 9
IP  - 2
DP  - 2011 Jun
TI  - Biobanking within the European regulatory framework: opportunities and obstacles.
PG  - 165-7
LID - 10.1089/bio.2010.0037 [doi]
AB  - A common feature of the European ethical and legal regulatory framework is that
      biobank-based research has a significant potential of providing new benefits to
      European citizens in terms of new medical treatment, and this research is
      therefore something that should be promoted. At the same time the legislatures
      are concerned, and rightly so, about the integrity of patients and healthy
      volunteers who provide samples and data. There is now ample evidence of how
      biobank-based research has provided great opportunities for new care. At the same
      time there are a growing number of reports about rash judgments about integrity
      by ethical review boards and data inspection authorities that are not in the best
      interest of patients. It is here argued that legislatures, ethical review boards,
      and data inspection authorities need to adopt a wider view of integrity and take 
      into consideration the patients' interest in a sound scientific basis for medical
      diagnosis and treatment.
FAU - Hansson, Mats G
AU  - Hansson MG
AD  - Department of Public Health and Caring Sciences, Centre for Research Ethics &
      Bioethics, Uppsala University , Uppsala, Sweden .
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Biopreserv Biobank
JT  - Biopreservation and biobanking
JID - 101507284
EDAT- 2011/06/01 00:00
MHDA- 2011/06/01 00:01
CRDT- 2014/05/22 06:00
PHST- 2014/05/22 06:00 [entrez]
PHST- 2011/06/01 00:00 [pubmed]
PHST- 2011/06/01 00:01 [medline]
AID - 10.1089/bio.2010.0037 [doi]
PST - ppublish
SO  - Biopreserv Biobank. 2011 Jun;9(2):165-7. doi: 10.1089/bio.2010.0037.


PMID- 24846259
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140522
LR  - 20160511
IS  - 1947-5535 (Print)
IS  - 1947-5543 (Linking)
VI  - 9
IP  - 2
DP  - 2011 Jun
TI  - Minimum biobanking requirements: issues in a comprehensive cancer center biobank.
PG  - 141-8
LID - 10.1089/bio.2011.0012 [doi]
AB  - Cancer biobanks, when located within a comprehensive cancer center, are
      characterized by management and organizational peculiarities mainly related to
      the multidisciplinary information available of such specialized centers and the
      continuous collection stream of quality-assessed biospecimens. The present study 
      summarizes the main characteristics of comprehensive cancer center biobanks and, 
      more in detail, procedures addressed in order to maintain full control over
      interlacement issues that occur at every level, from patient enrolment
      eligibility and consenting to dissemination and utilization of specimens and
      associated data. Dedicated personnel, appropriate storage facilities, as well as 
      ethical, legal, and technical requirements are among the most relevant aspects
      strongly conditioning the quality of these structures. Because of its location
      and the need to be directly connected with clinical units, such as pathology,
      oncology, surgery, etc., ad hoc information technology tools are crucial to
      support all aspects of biorepository operations, including (but not limited to)
      patient enrolment and consent; biospecimen collection, processing, storage, and
      distribution; quality assurance and quality control; collection of patient data; 
      validation documentation; and management reporting functions.
FAU - Pelagio, Giuseppe
AU  - Pelagio G
AD  - 1 Giovanni Paolo II National Cancer Center , Bari, Italy .
FAU - Pistillo, Daniela
AU  - Pistillo D
FAU - Mottolese, Marcella
AU  - Mottolese M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Biopreserv Biobank
JT  - Biopreservation and biobanking
JID - 101507284
EDAT- 2011/06/01 00:00
MHDA- 2011/06/01 00:01
CRDT- 2014/05/22 06:00
PHST- 2014/05/22 06:00 [entrez]
PHST- 2011/06/01 00:00 [pubmed]
PHST- 2011/06/01 00:01 [medline]
AID - 10.1089/bio.2011.0012 [doi]
PST - ppublish
SO  - Biopreserv Biobank. 2011 Jun;9(2):141-8. doi: 10.1089/bio.2011.0012.


PMID- 24298328
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20211021
IS  - 2005-3606 (Print)
IS  - 2005-3606 (Linking)
VI  - 4
IP  - 1
DP  - 2011 Jun
TI  - Reprogrammed pluripotent stem cells from somatic cells.
PG  - 1-8
AB  - Pluripotent stem cells, such as embryonic stem (ES) cells, can differentiate into
      all cell types. So, these cells can be a biological resource for regenerative
      medicine. However, ES cells known as standard pluripotent cells have problem to
      be used for cell therapy because of ethical issue of the origin and immune
      response on the graft. Hence, recently reprogrammed pluripotent cells have been
      suggested as an alternative source for regenerative medicine. Somatic cells can
      acquire the ES cell-like pluripotency by transferring somatic cell nuclei into
      oocytes, by cell fusion with pluripotent cells. Retroviral-mediated introduction 
      of four factors, Oct4, Sox2, Klf4 and c-Myc can successfully reprogram somatic
      cells into ES cell-like pluripotent stem cells, known as induced pluripotent stem
      (iPS) cells. These cells closely resemble ES cells in gene expression pattern,
      cell biologic and phenotypic characteristics. However, to reach the eventual goal
      of clinical application, it is necessary to overcome the major drawbacks such as 
      low reprogramming efficiency and genomic alterations due to viral integration. In
      this review, we discuss the current reprogramming techniques and mechanisms of
      nuclear reprogramming induced by transcription factor transduction.
FAU - Kim, Jong Soo
AU  - Kim JS
AD  - Laboratory of Stem Cell and Developmental Biology, Department of Life Science,
      CHA University, Seoul, Korea.
FAU - Choi, Hyun Woo
AU  - Choi HW
FAU - Choi, Sol
AU  - Choi S
FAU - Do, Jeong Tae
AU  - Do JT
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Korea (South)
TA  - Int J Stem Cells
JT  - International journal of stem cells
JID - 101497587
PMC - PMC3840974
OTO - NOTNLM
OT  - Cell fusion hybrid
OT  - Embryonic stem cell
OT  - Induced pluripotent stem cell
OT  - Pluripotency
OT  - Somatic cell nuclear transfer
EDAT- 2011/06/01 00:00
MHDA- 2011/06/01 00:01
CRDT- 2013/12/04 06:00
PHST- 2011/03/06 00:00 [accepted]
PHST- 2013/12/04 06:00 [entrez]
PHST- 2011/06/01 00:00 [pubmed]
PHST- 2011/06/01 00:01 [medline]
AID - 10.15283/ijsc.2011.4.1.1 [doi]
PST - ppublish
SO  - Int J Stem Cells. 2011 Jun;4(1):1-8. doi: 10.15283/ijsc.2011.4.1.1.


PMID- 23199147
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121204
LR  - 20211021
IS  - 1878-5085 (Electronic)
IS  - 1878-5077 (Linking)
VI  - 2
IP  - 2
DP  - 2011 Jun
TI  - Genetic testing: predictive value of genotyping for diagnosis and management of
      disease.
PG  - 173-9
LID - 10.1007/s13167-011-0077-y [doi]
AB  - This article describes predictive, preventive value of genetic tests and the
      implication of the use of testing for personalized treatment. This year marks the
      10th anniversity of publishing of the sequence of the human genome. One important
      area of application of this mega project is a development of genetic tests for
      mutation detection in single gene disorders that has impact for pediatric age
      group patients and analyzing susceptibility genes as risk factors in common
      disorders. Types of genetic tests, new emerging technologies will enable
      developments of high-throughput approaches by microarrays of great application
      capacity as described here. As it is usual for all technologies used in health
      care, bioethical concerns has to be delt with. The ethical, social and governance
      issues associated with genetic testing are discussed.
FAU - Ozguc, Meral
AU  - Ozguc M
AD  - Department of Medical Biology, Faculty of Medicine, Hacettepe University, Ankara,
      Turkey.
LA  - eng
PT  - Journal Article
DEP - 20110506
PL  - Switzerland
TA  - EPMA J
JT  - The EPMA journal
JID - 101517307
PMC - PMC3405385
EDAT- 2011/06/01 00:00
MHDA- 2011/06/01 00:01
CRDT- 2012/12/04 06:00
PHST- 2011/02/15 00:00 [received]
PHST- 2011/03/29 00:00 [accepted]
PHST- 2012/12/04 06:00 [entrez]
PHST- 2011/06/01 00:00 [pubmed]
PHST- 2011/06/01 00:01 [medline]
AID - 10.1007/s13167-011-0077-y [doi]
AID - 77 [pii]
PST - ppublish
SO  - EPMA J. 2011 Jun;2(2):173-9. doi: 10.1007/s13167-011-0077-y. Epub 2011 May 6.


PMID- 23199143
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121204
LR  - 20220330
IS  - 1878-5085 (Electronic)
IS  - 1878-5077 (Linking)
VI  - 2
IP  - 2
DP  - 2011 Jun
TI  - Does the "new philosophy" in predictive, preventive and personalised medicine
      require new ethics?
PG  - 141-7
LID - 10.1007/s13167-011-0078-x [doi]
AB  - This paper maps the ethical issues that arise in the context of personalised
      medicine. First, it highlights the ethical problems related to increased
      predictive power of modern diagnostic interventions. Such problems emerge because
      the ability to identify individuals or groups of individuals that can potentially
      benefit from a particular therapeutic intervention also raises a question of
      personal responsibility for health-related behaviour and lifestyle. The second
      major area of ethical concern is related to health prevention and distributive
      justice. The paper discusses the ethical challenges brought by the personalised
      medicine in the context of the Additional Protocol to the Convention on Human
      Rights and Biomedicine concerning Genetic Testing for Health Purposes. Finally,
      it notes that the issue of consent in the context of biobanks, the need to
      rethink the prevalent models of research designs and to communicate relevant
      findings to the donors of biological materials deserve further discussion.
FAU - Gefenas, Eugenijus
AU  - Gefenas E
AD  - Faculty of Medicine, Department of Medical History and Ethics, Vilnius
      University, M.K.Ciurlionio Str. 21/27, Vilnius, LT 03101 Lithuania.
FAU - Cekanauskaite, Asta
AU  - Cekanauskaite A
FAU - Tuzaite, Egle
AU  - Tuzaite E
FAU - Dranseika, Vilius
AU  - Dranseika V
FAU - Characiejus, Dainius
AU  - Characiejus D
LA  - eng
PT  - Journal Article
DEP - 20110420
PL  - Switzerland
TA  - EPMA J
JT  - The EPMA journal
JID - 101517307
PMC - PMC3405379
EDAT- 2011/06/01 00:00
MHDA- 2011/06/01 00:01
CRDT- 2012/12/04 06:00
PHST- 2011/03/16 00:00 [received]
PHST- 2011/03/30 00:00 [accepted]
PHST- 2012/12/04 06:00 [entrez]
PHST- 2011/06/01 00:00 [pubmed]
PHST- 2011/06/01 00:01 [medline]
AID - 10.1007/s13167-011-0078-x [doi]
AID - 78 [pii]
PST - ppublish
SO  - EPMA J. 2011 Jun;2(2):141-7. doi: 10.1007/s13167-011-0078-x. Epub 2011 Apr 20.


PMID- 23198101
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121203
LR  - 20211021
IS  - 2047-2986 (Electronic)
IS  - 2047-2978 (Linking)
VI  - 1
IP  - 1
DP  - 2011 Jun
TI  - The case for launch of an international DNA-based birth cohort study.
PG  - 39-45
AB  - The global health agenda beyond 2015 will inevitably need to broaden its focus
      from mortality reduction to the social determinants of deaths, growing inequities
      among children and mothers, and ensuring the sustainability of the progress made 
      against the infectious diseases. New research tools, including technologies that 
      enable high-throughput genetic and '-omics' research, could be deployed for
      better understanding of the aetiology of maternal and child health problems. The 
      research needed to address those challenges will require conceptually different
      studies than those used in the past. It should be guided by stringent ethical
      frameworks related to the emerging collections of biological specimens and other 
      health related information. We will aim to establish an international birth
      cohort which should assist low- and middle-income countries to use emerging
      genomic research technologies to address the main problems in maternal and child 
      health, which are still major contributors to the burden of disease globally.
FAU - Rudan, Igor
AU  - Rudan I
AD  - Centre for Population Health Sciences and Global Health Academy, University of
      Edinburgh, Scotland, UK ; Croatian Centre for Global Health, Faculty of Medicine,
      University of Split, Croatia.
FAU - Chopra, Mickey
AU  - Chopra M
FAU - Aulchenko, Yurii
AU  - Aulchenko Y
FAU - Baqui, Abdullah H
AU  - Baqui AH
FAU - Bhutta, Zulfiqar A
AU  - Bhutta ZA
FAU - Edmond, Karen
AU  - Edmond K
FAU - Horta, Bernardo L
AU  - Horta BL
FAU - Klugman, Keith P
AU  - Klugman KP
FAU - Lanata, Claudio F
AU  - Lanata CF
FAU - Madhi, Shabir A
AU  - Madhi SA
FAU - Nair, Harish
AU  - Nair H
FAU - Qureshi, Zeshan
AU  - Qureshi Z
FAU - Rubens, Craig
AU  - Rubens C
FAU - Theodoratou, Evropi
AU  - Theodoratou E
FAU - Victora, Cesar G
AU  - Victora CG
FAU - Wang, Wei
AU  - Wang W
FAU - Weber, Martin W
AU  - Weber MW
FAU - Wilson, James F
AU  - Wilson JF
FAU - Zgaga, Lina
AU  - Zgaga L
FAU - Campbell, Harry
AU  - Campbell H
LA  - eng
PT  - Journal Article
PL  - Scotland
TA  - J Glob Health
JT  - Journal of global health
JID - 101578780
PMC - PMC3484746
EDAT- 2011/06/01 00:00
MHDA- 2011/06/01 00:01
CRDT- 2012/12/01 06:00
PHST- 2012/12/01 06:00 [entrez]
PHST- 2011/06/01 00:00 [pubmed]
PHST- 2011/06/01 00:01 [medline]
PST - ppublish
SO  - J Glob Health. 2011 Jun;1(1):39-45.


PMID- 23198094
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121203
LR  - 20220410
IS  - 2047-2986 (Electronic)
IS  - 2047-2978 (Linking)
VI  - 1
IP  - 1
DP  - 2011 Jun
TI  - Developing biobanks in developing countries.
PG  - 2-4
AB  - We call for the development of human biobanks in developing countries and
      describe several examples from low income countries which are already building
      their own biobanks. Developing human biobanks in developing countries requires
      strengthening of the research capacity to use the new technologies, as well as a 
      shift in research investment priorities in order to reduce the inequity in
      international research that currently exists. A responsible approach from
      low-income countries to ethical issues will be another pre-requisite to the
      success of the 'hypothesis-free' research that will target the needs of the
      world's poor.
FAU - Rudan, Igor
AU  - Rudan I
FAU - Marusic, Ana
AU  - Marusic A
FAU - Campbell, Harry
AU  - Campbell H
LA  - eng
PT  - Journal Article
PL  - Scotland
TA  - J Glob Health
JT  - Journal of global health
JID - 101578780
PMC - PMC3484738
EDAT- 2011/06/01 00:00
MHDA- 2011/06/01 00:01
CRDT- 2012/12/01 06:00
PHST- 2012/12/01 06:00 [entrez]
PHST- 2011/06/01 00:00 [pubmed]
PHST- 2011/06/01 00:01 [medline]
PST - ppublish
SO  - J Glob Health. 2011 Jun;1(1):2-4.


PMID- 23193867
OWN - NLM
STAT- MEDLINE
DCOM- 20130108
LR  - 20121130
IS  - 1029-4864 (Print)
IS  - 1029-4864 (Linking)
VI  - 66
IP  - 5
DP  - 2011 Jun
TI  - Dental ethics case 12. My patient wants to sue their previous practitioner for
      failed endodontic treatment--how should I advise them?
PG  - 238-9
FAU - Naidoo, S
AU  - Naidoo S
AD  - Department of Community Oral Health, University of the Western Cape, Private Bag 
      X1, Tygerberg, 7505. suenaidoo@uwc.ac.za
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - SADJ
JT  - SADJ : journal of the South African Dental Association = tydskrif van die
      Suid-Afrikaanse Tandheelkundige Vereniging
JID - 9812497
MH  - Dentist-Patient Relations/ethics
MH  - Dentists/*ethics
MH  - *Ethics, Dental
MH  - Humans
MH  - Interprofessional Relations/ethics
MH  - *Malpractice
MH  - Practice Valuation and Purchase/ethics
MH  - Root Canal Therapy/*ethics
MH  - Treatment Failure
EDAT- 2011/06/01 00:00
MHDA- 2013/01/09 06:00
CRDT- 2012/12/01 06:00
PHST- 2012/12/01 06:00 [entrez]
PHST- 2011/06/01 00:00 [pubmed]
PHST- 2013/01/09 06:00 [medline]
PST - ppublish
SO  - SADJ. 2011 Jun;66(5):238-9.


PMID- 21623238
OWN - NLM
STAT- MEDLINE
DCOM- 20111209
LR  - 20220317
IS  - 1556-1380 (Electronic)
IS  - 1556-0864 (Linking)
VI  - 6
IP  - 7
DP  - 2011 Jul
TI  - CXCR4 overexpression is associated with poor outcome in females diagnosed with
      stage IV non-small cell lung cancer.
PG  - 1169-78
LID - 10.1097/JTO.0b013e3182199a99 [doi]
AB  - BACKGROUND: It has been proposed that the chemokine receptor, CXCR4, and its
      ligand, stromal cell-derived factor-1 (SDF-1), play a critical role in
      organ-specific tumor metastasis. High CXCR4 expression in resected non-small cell
      lung cancer (NSCLC) tumors is associated with poorer outcome; however, its effect
      on patient outcome in advanced NSCLC has not been explored. METHODS: After
      institutional ethical approval was obtained, demographic details, clinical
      variables, and outcome data were collected on consecutive NSCLC patients
      diagnosed at the Tom Baker Cancer Centre from 2003 to 2006 (Glans-Look Lung
      Cancer Database). Formalin-fixed paraffin-embedded diagnostic biopsies from stage
      IV patients were obtained and tissue microarrays generated. CXCR4 expression
      within NSCLC cells was analyzed by quantitative fluorescent immunohistochemistry 
      using the HistoRx PM-2000 platform and then correlated with clinical outcome.
      RESULTS: Of 832 patients, 170 had samples suitable for tissue microarray
      generation and analysis. Automated immunohistochemistry for CXCR4 was
      successfully completed on all 170 patients. High expressors had a significantly
      poorer median overall survival of 2.7 months versus 5.6 months for the low
      expressors (p = 0.0468). This difference is driven by high-expressing females who
      have a median overall survival of 1.6 months versus 6.4 months for the low
      expressors (p = 0.006). CONCLUSIONS: CXCR4 is expressed in the majority of NSCLC 
      tumors, and overexpression is associated with significantly poorer survival in
      stage IV NSCLC patients. Interestingly, this poor outcome is disproportionately
      represented in the female population. Our results suggest a gender-dependent
      difference in clinical outcome based on CXCR4 overexpression in stage IV NSCLC.
FAU - Otsuka, Shannon
AU  - Otsuka S
AD  - Translational Research Laboratory, Tom Baker Cancer Centre and University of
      Calgary, Calgary, Alberta, Canada.
FAU - Klimowicz, Alexander C
AU  - Klimowicz AC
FAU - Kopciuk, Karen
AU  - Kopciuk K
FAU - Petrillo, Stephanie K
AU  - Petrillo SK
FAU - Konno, Mie
AU  - Konno M
FAU - Hao, Desiree
AU  - Hao D
FAU - Muzik, Huong
AU  - Muzik H
FAU - Stolte, Erin
AU  - Stolte E
FAU - Boland, William
AU  - Boland W
FAU - Morris, Don
AU  - Morris D
FAU - Magliocco, Anthony M
AU  - Magliocco AM
FAU - Bebb, D Gwyn
AU  - Bebb DG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Thorac Oncol
JT  - Journal of thoracic oncology : official publication of the International
      Association for the Study of Lung Cancer
JID - 101274235
RN  - 0 (Receptors, CXCR4)
SB  - IM
MH  - Adenocarcinoma/*metabolism/mortality/pathology
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Large Cell/*metabolism/mortality/pathology
MH  - Carcinoma, Non-Small-Cell Lung/*metabolism/mortality/pathology
MH  - Carcinoma, Squamous Cell/*metabolism/mortality/pathology
MH  - Cohort Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Lung Neoplasms/*metabolism/mortality/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Receptors, CXCR4/*metabolism
MH  - Retrospective Studies
MH  - Sex Factors
MH  - Survival Rate
MH  - Tissue Array Analysis
EDAT- 2011/05/31 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/05/31 06:00
PHST- 2011/05/31 06:00 [entrez]
PHST- 2011/05/31 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 10.1097/JTO.0b013e3182199a99 [doi]
AID - S1556-0864(15)31032-7 [pii]
PST - ppublish
SO  - J Thorac Oncol. 2011 Jul;6(7):1169-78. doi: 10.1097/JTO.0b013e3182199a99.


PMID- 21621878
OWN - NLM
STAT- MEDLINE
DCOM- 20120827
LR  - 20161125
IS  - 1578-1968 (Electronic)
IS  - 0213-4853 (Linking)
VI  - 27
IP  - 1
DP  - 2012 Jan
TI  - [Patients with mild cognitive impairment and a reduced CSF Abeta(1)(-)(4)(2)
      protein progress rapidly to Alzheimer's disease].
PG  - 28-33
LID - 10.1016/j.nrl.2011.03.014 [doi]
AB  - INTRODUCTION: Some studies have shown that CSF amyloid-beta 1-42
      (Abeta(1)(-)(4)(2)), total tau (T-tau) and tau phosphorylated at threonine 181
      (P-tau(181p)) proteins are useful diagnostic markers for distinguishing between
      clinically stable mild cognitive impairment (MCI) patients and those who will
      develop Alzheimers disease (AD). Our objective was to test the ability of this
      technique to discriminate in our cohort of MCI patients, according to the
      clinical outcome, one year after the lumbar puncture. MATERIAL AND METHODS: A
      total of 36 MCI patients were included from the local hospital memory clinic.
      Using INNO-BIA Alzbio-3 reagents from Innogenetics, we measured CSF
      Abeta(1)(-)(4)(2), T-tau and P-tau(181p) proteins, and calculated the
      T-tau/Abeta(1)(-)(4)(2) y P-tau(181p)/Abeta(1)(-)(4)(2) ratios. This project was 
      approved by the local ethics committee. RESULTS: One year after the lumbar
      puncture, 14 MCI patients (38%) developed AD. These patients had lower
      Abeta(1)(-)(4)(2) protein levels (285.3 vs 377 ng/ml, P<.02) and higher
      P-tau(181p)/Abeta(1)(-)(4)(2) ratio (0,25 vs 0,16, p<.02) than the clinically
      stable patients. CONCLUSIONS: Our MCI patients with lower Abeta(1)(-)(4)(2)
      protein levels and an increased P-tau(181p) /Abeta(1)(-)(4)(2) ratio progressed
      quickly to AD. These results may help to identify those MCI patients with a
      poorer prognosis.
CI  - Copyright A(c) 2010 Sociedad Espanola de Neurologia. Published by Elsevier
      Espana. All rights reserved.
FAU - Monge-Argiles, J A
AU  - Monge-Argiles JA
AD  - Servicio de Neurologia, Hospital General Universitario de Alicante, Alicante,
      Espana. monge jos@gva.es
FAU - Sanchez-Paya, J
AU  - Sanchez-Paya J
FAU - Munoz-Ruiz, C
AU  - Munoz-Ruiz C
FAU - Pampliega-Perez, A
AU  - Pampliega-Perez A
FAU - Gomez-Lopez, M J
AU  - Gomez-Lopez MJ
FAU - Rodriguez Borja, E
AU  - Rodriguez Borja E
FAU - Montoya-Gutierrez, J
AU  - Montoya-Gutierrez J
FAU - Leiva-Santana, C
AU  - Leiva-Santana C
LA  - spa
PT  - Journal Article
TT  - Pacientes con deterioro cognitivo leve y reduccion de la proteina Abeta(1-42) en 
      LCR evolucionan rapidamente a enfermedad de Alzheimer.
DEP - 20110531
PL  - Spain
TA  - Neurologia
JT  - Neurologia (Barcelona, Spain)
JID - 9005460
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Biomarkers)
RN  - 0 (Peptide Fragments)
RN  - 0 (amyloid beta-protein (1-42))
RN  - 0 (tau Proteins)
SB  - IM
MH  - Aged
MH  - Alzheimer Disease/*cerebrospinal fluid/*etiology
MH  - Amnesia/etiology
MH  - Amyloid beta-Peptides/*cerebrospinal fluid
MH  - Biomarkers/cerebrospinal fluid
MH  - Cognitive Dysfunction/*cerebrospinal fluid/*complications
MH  - Cohort Studies
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Immunoassay
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Peptide Fragments/*cerebrospinal fluid
MH  - Prognosis
MH  - ROC Curve
MH  - Reproducibility of Results
MH  - Spinal Puncture
MH  - tau Proteins/cerebrospinal fluid
EDAT- 2011/05/31 06:00
MHDA- 2012/08/28 06:00
CRDT- 2011/05/31 06:00
PHST- 2010/12/18 00:00 [received]
PHST- 2011/03/21 00:00 [revised]
PHST- 2011/03/27 00:00 [accepted]
PHST- 2011/05/31 06:00 [entrez]
PHST- 2011/05/31 06:00 [pubmed]
PHST- 2012/08/28 06:00 [medline]
AID - S0213-4853(11)00161-7 [pii]
AID - 10.1016/j.nrl.2011.03.014 [doi]
PST - ppublish
SO  - Neurologia. 2012 Jan;27(1):28-33. doi: 10.1016/j.nrl.2011.03.014. Epub 2011 May
      31.


PMID- 21621805
OWN - NLM
STAT- MEDLINE
DCOM- 20111128
LR  - 20161109
IS  - 1578-178X (Electronic)
IS  - 0033-8338 (Linking)
VI  - 53
IP  - 3
DP  - 2011 May-Jun
TI  - [How to write an original article for a biomedical journal].
PG  - 209-19
LID - 10.1016/j.rx.2011.02.006 [doi]
AB  - Writing a scientific article is difficult, but skillful writing does not depend
      only on talent. This skill can be learned, and writing requires discipline and
      dedication. This article discusses the basic characteristics of the IMRaD
      (Introduction, Material and methods, Results, and Discussion) format and the
      contents of each section, as well as the characteristics of the title, abstract, 
      and bibliographical references. It also provides a list of five characteristics
      that are essential for an original article published in a scientific journal:
      objective, permission of the ethics committee, a structured material and methods 
      section, results that follow appropriately from the material and methods section,
      and a structured discussion. Furthermore, we provide a basic outline for the
      discussion section consisting of stating the most important results, developing a
      critical discussion of the results, stating and discussing the strengths and
      limitations of the study, and elaborating the final synthesis.
CI  - Copyright (c) 2011 SERAM. Published by Elsevier Espana. All rights reserved.
FAU - Garcia Santos, J M
AU  - Garcia Santos JM
AD  - Servicio de Radiologia, Hospital General Universitario Morales Meseguer, Murcia, 
      Espana. josem.garcia11@carm.es
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Como escribir un articulo original para una revista biomedica.
DEP - 20110531
PL  - Spain
TA  - Radiologia
JT  - Radiologia
JID - 0120775
SB  - IM
MH  - *Periodicals as Topic
MH  - Writing/*standards
EDAT- 2011/05/31 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/05/31 06:00
PHST- 2011/01/30 00:00 [received]
PHST- 2011/02/27 00:00 [revised]
PHST- 2011/02/28 00:00 [accepted]
PHST- 2011/05/31 06:00 [entrez]
PHST- 2011/05/31 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0033-8338(11)00086-5 [pii]
AID - 10.1016/j.rx.2011.02.006 [doi]
PST - ppublish
SO  - Radiologia. 2011 May-Jun;53(3):209-19. doi: 10.1016/j.rx.2011.02.006. Epub 2011
      May 31.


PMID- 21621477
OWN - NLM
STAT- MEDLINE
DCOM- 20120620
LR  - 20120221
IS  - 1538-9375 (Electronic)
IS  - 1525-8610 (Linking)
VI  - 13
IP  - 3
DP  - 2012 Mar
TI  - Prevention of venous thromboembolism in long term care: results of a multicenter 
      educational intervention using clinical practice guidelines: part 2 of 2 (an AMDA
      Foundation project).
PG  - 303-7
LID - 10.1016/j.jamda.2011.04.015 [doi]
AB  - INTRODUCTION: Implementation of prophylaxis for venous thomboembolism (VTE)
      through risk assessment based on clinical practice guidelines (CPGs) is variably 
      adopted in long term care facilities (LTCF). Current guidelines recommend venous 
      thromboembolism prophylaxis (VTE-P) following risk assessment, individualized to 
      patient status. In LTCF, differing comorbidity, life-expectancy, ethical, and
      quality-of-life issues may warrant a unique approach. This article examines VTE-P
      practices in LTCF before and after educational intervention to bring practice
      patterns consistent with CPGs. METHODS: Phase 1 (preceding article in this issue)
      identified current practice to assess risk and implement VTE-P (17 geographically
      diverse LTCFs, 3260 total beds). Phase 2 (educational intervention using CPGs)
      and Phase 3 (outcomes) reexamined VTE-P at the same 17 centers. RESULTS: The
      frequency of indications for VTE-P and contraindications to anticoagulation were 
      similar during Phases 1 and 3 (all P > .05). In Phase 3, use of aspirin alone
      decreased more than 50% (P < .0005), whereas use of compression devices increased
      (P < .0005). Regression models predicted no relationship between any indication
      or contraindication and VTE-P in Phase 1 (all P > .05) but identified significant
      relationships between indication and contraindications and VTE-P in Phase 3 (P = 
      .022 to P < .0005), suggesting adequate understanding of current CPGs following
      education as the basis for improved VTE-P. CONCLUSIONS: The study confirms the
      presence of significant comorbidity in LTC residents, many with indications for
      VTE-P, some with contraindications for anticoagulation. Following educational
      intervention, more residents received VTE-P, influenced by risk-benefit ratio
      favoring treatment. These findings suggest that even a modest educational
      intervention significantly improves provider knowledge pertinent to risk
      assessment consistent with CPG and more appropriate VTE-P.
CI  - Copyright A(c) 2012 American Medical Directors Association, Inc. Published by
      Elsevier Inc. All rights reserved.
FAU - Dharmarajan, T S
AU  - Dharmarajan TS
AD  - New York Medical College and Montefiore Medical Center North, Bronx, NY, USA.
      dharmarajants@yahoo.com
FAU - Nanda, Aman
AU  - Nanda A
FAU - Agarwal, Bikash
AU  - Agarwal B
FAU - Agnihotri, Parag
AU  - Agnihotri P
FAU - Doxsie, G L
AU  - Doxsie GL
FAU - Gokula, Murthy
AU  - Gokula M
FAU - Javaheri, Ashkan
AU  - Javaheri A
FAU - Kanagala, M
AU  - Kanagala M
FAU - Lebelt, Anna S
AU  - Lebelt AS
FAU - Madireddy, Prasuna
AU  - Madireddy P
FAU - Mahapatra, Sourya
AU  - Mahapatra S
FAU - Murakonda, P
AU  - Murakonda P
FAU - Muthavarapu, S Ram Rao
AU  - Muthavarapu SR
FAU - Patel, Mennakshi
AU  - Patel M
FAU - Patterson, Christopher
AU  - Patterson C
FAU - Soch, Kathleen
AU  - Soch K
FAU - Troncales, Anna
AU  - Troncales A
FAU - Yaokim, Kamal
AU  - Yaokim K
FAU - Kroft, Robin
AU  - Kroft R
FAU - Norkus, Edward P
AU  - Norkus EP
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20110531
PL  - United States
TA  - J Am Med Dir Assoc
JT  - Journal of the American Medical Directors Association
JID - 100893243
RN  - 0 (Anticoagulants)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Anticoagulants/therapeutic use
MH  - Female
MH  - Health Personnel/education
MH  - Humans
MH  - *Inservice Training
MH  - Male
MH  - Medical Audit
MH  - *Nursing Homes
MH  - *Practice Guidelines as Topic
MH  - Risk Assessment
MH  - United States
MH  - Venous Thromboembolism/*prevention & control
EDAT- 2011/05/31 06:00
MHDA- 2012/06/21 06:00
CRDT- 2011/05/31 06:00
PHST- 2011/02/04 00:00 [received]
PHST- 2011/04/17 00:00 [revised]
PHST- 2011/04/18 00:00 [accepted]
PHST- 2011/05/31 06:00 [entrez]
PHST- 2011/05/31 06:00 [pubmed]
PHST- 2012/06/21 06:00 [medline]
AID - S1525-8610(11)00143-5 [pii]
AID - 10.1016/j.jamda.2011.04.015 [doi]
PST - ppublish
SO  - J Am Med Dir Assoc. 2012 Mar;13(3):303-7. doi: 10.1016/j.jamda.2011.04.015. Epub 
      2011 May 31.


PMID- 21621372
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20220410
IS  - 1526-3231 (Electronic)
IS  - 0749-8063 (Linking)
VI  - 27
IP  - 7
DP  - 2011 Jul
TI  - Relation of tunnel enlargement and tunnel placement after single-bundle anterior 
      cruciate ligament reconstruction.
PG  - 923-32
LID - 10.1016/j.arthro.2011.02.020 [doi]
AB  - PURPOSE: To determine the relation between tunnel placement and tunnel
      enlargement after single-bundle anterior cruciate ligament (ACL) reconstruction. 
      METHODS: Seventy-two subjects (mean age, 30.1 years; 17.5 months' follow-up) who 
      underwent single-bundle ACL reconstruction with hamstring autograft were studied.
      EndoButton fixation (Ethicon, Somerville, NJ) was used on the femoral side,
      whereas staples were used on the tibial side. A transtibial femoral tunnel
      position technique was used in 53 subjects, whereas positioning through the
      medial portal was used in the other 19 cases. Tunnel enlargement was determined
      by comparing the diameter of the tunnel on the radiograph obtained after 12
      months and the radiograph obtained instantly after the operation. The centers of 
      the femoral and tibial tunnels and the angles between the graft and tibial
      plateau were also measured on standard radiographs. Clinical outcomes including
      KT-1000 assessment (MEDmetric, San Diego, CA) and International Knee
      Documentation Committee (IKDC) score were also collected in all patients. The
      relations between tunnel enlargement/tunnel position and knee joint laxity and
      IKDC score were analyzed. RESULTS: The mean KT-1000 side-to-side difference
      significantly decreased, from 6.07 +/- 2.75 mm to 1.57 +/- 2.14 mm, after ACL
      reconstruction; the IKDC subjective score increased from 52.8 to 87.5. On lateral
      radiographs, the tunnel enlargement rates were 41% on the femoral side and 35% on
      the tibial side; on plain anteroposterior radiographs, the tunnel enlargement
      rates were 39% on the femoral side and 32% on the tibial side. Subjects with a
      higher femoral tunnel had a greater enlargement rate (P < .001). Subjects with a 
      more vertical graft also had a larger femoral enlargement (P < .05). More
      anterior placement of the femoral tunnel was associated with larger tibial tunnel
      enlargement on anteroposterior plain radiographs (P < .05). A more vertical graft
      was also associated with larger tibial tunnel enlargement. Subjects in whom the
      transtibial femoral position technique was used had more femoral tunnel
      enlargements (P < .01). CONCLUSIONS: Drilling the femoral tunnel through the
      medial portal created a lower, more posterior, and less vertical tunnel than
      drilling through the tibial tunnel. Femoral and tibial tunnel enlargements were
      greater with more anterior, more proximal, and more vertical femoral tunnels.
      Whereas no clinical differences were seen in the 2 groups, drilling the femoral
      tunnel from the medial portal will result in smaller postoperative tunnel
      enlargements. LEVEL OF EVIDENCE: Level III, retrospective comparative study.
CI  - Copyright (c) 2011 Arthroscopy Association of North America. Published by
      Elsevier Inc. All rights reserved.
FAU - Xu, Yan
AU  - Xu Y
AD  - Institute of Sports Medicine, Third Hospital of Peking University, Beijing,
      China.
FAU - Ao, Yingfang
AU  - Ao Y
FAU - Wang, Jianquan
AU  - Wang J
FAU - Yu, Jiakuo
AU  - Yu J
FAU - Cui, Guoqing
AU  - Cui G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110531
PL  - United States
TA  - Arthroscopy
JT  - Arthroscopy : the journal of arthroscopic & related surgery : official
      publication of the Arthroscopy Association of North America and the International
      Arthroscopy Association
JID - 8506498
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anterior Cruciate Ligament/*surgery
MH  - Arthrography
MH  - Femur/*diagnostic imaging/*surgery
MH  - Follow-Up Studies
MH  - Humans
MH  - Knee Joint/diagnostic imaging
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Reconstructive Surgical Procedures/*methods
MH  - Retrospective Studies
MH  - Tendons/*transplantation
MH  - Thigh
MH  - Tibia/*diagnostic imaging/*surgery
MH  - Transplantation, Autologous
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2011/05/31 06:00
MHDA- 2011/11/09 06:00
CRDT- 2011/05/31 06:00
PHST- 2010/07/26 00:00 [received]
PHST- 2011/02/10 00:00 [revised]
PHST- 2011/02/11 00:00 [accepted]
PHST- 2011/05/31 06:00 [entrez]
PHST- 2011/05/31 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - S0749-8063(11)00168-X [pii]
AID - 10.1016/j.arthro.2011.02.020 [doi]
PST - ppublish
SO  - Arthroscopy. 2011 Jul;27(7):923-32. doi: 10.1016/j.arthro.2011.02.020. Epub 2011 
      May 31.


PMID- 21621131
OWN - NLM
STAT- MEDLINE
DCOM- 20111205
LR  - 20110530
IS  - 1873-6513 (Electronic)
IS  - 0885-3924 (Linking)
VI  - 41
IP  - 6
DP  - 2011 Jun
TI  - The ethics of pacemaker deactivation in terminally ill patients.
PG  - 1106-10
LID - 10.1016/j.jpainsymman.2011.03.003 [doi]
AB  - A core principle of American medical ethics holds that an informed and
      capacitated patient has the right to have treatments withdrawn or withheld.
      Nevertheless, many clinicians remain reluctant to honor a request to deactivate a
      patient's pacemaker. This article describes a case in which a patient was denied 
      her request for pacemaker deactivation. Several reasons for this reluctance are
      discussed, including historical, practical, and ethical considerations for
      opposing pacemaker deactivation. Ultimately, however, from an ethical standpoint,
      pacemaker deactivation is similar to withdrawal of other therapies. Fortunately, 
      a recent expert consensus statement supports a patient's right to have her
      pacemaker deactivated. Pacemaker deactivation should only be performed after
      robust informed consent, which must include discussion of risks, benefits, and
      all viable alternatives based on the patient's values and goals.
CI  - Copyright (c) 2011 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. 
      All rights reserved.
FAU - Bevins, Michael B
AU  - Bevins MB
AD  - Central Texas Palliative Care Associates, Hospice Austin, Austin, Texas 78759,
      USA. mbevins@hospiceaustin.org
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Pain Symptom Manage
JT  - Journal of pain and symptom management
JID - 8605836
SB  - IM
MH  - Aged
MH  - Female
MH  - Heart Failure/*prevention & control
MH  - Humans
MH  - Pacemaker, Artificial/*ethics
MH  - Palliative Care
MH  - Terminal Care
MH  - *Terminally Ill
MH  - Treatment Refusal/*ethics
MH  - United States
MH  - Withholding Treatment/*ethics
EDAT- 2011/05/31 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/05/31 06:00
PHST- 2010/11/30 00:00 [received]
PHST- 2011/02/18 00:00 [revised]
PHST- 2011/03/03 00:00 [accepted]
PHST- 2011/05/31 06:00 [entrez]
PHST- 2011/05/31 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0885-3924(11)00202-8 [pii]
AID - 10.1016/j.jpainsymman.2011.03.003 [doi]
PST - ppublish
SO  - J Pain Symptom Manage. 2011 Jun;41(6):1106-10. doi:
      10.1016/j.jpainsymman.2011.03.003.


PMID- 21620457
OWN - NLM
STAT- MEDLINE
DCOM- 20111123
LR  - 20200401
IS  - 1527-2966 (Electronic)
IS  - 0099-1767 (Linking)
VI  - 37
IP  - 4
DP  - 2011 Jul
TI  - Ethical issues of hospital crowding solutions.
PG  - 381-5
LID - 10.1016/j.jen.2011.04.015 [doi]
FAU - Braun, Brenda
AU  - Braun B
AD  - Shore Memorial Hospital, Somers Point, NJ, USA. njenabb@comcast.net
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110526
PL  - United States
TA  - J Emerg Nurs
JT  - Journal of emergency nursing
JID - 7605913
MH  - *Crowding
MH  - Emergency Service, Hospital/*ethics
MH  - Health Services Accessibility/*ethics
MH  - Humans
MH  - Practice Guidelines as Topic
MH  - Triage/ethics/methods
MH  - United States
EDAT- 2011/05/31 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/05/31 06:00
PHST- 2011/05/31 06:00 [entrez]
PHST- 2011/05/31 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0099-1767(11)00205-4 [pii]
AID - 10.1016/j.jen.2011.04.015 [doi]
PST - ppublish
SO  - J Emerg Nurs. 2011 Jul;37(4):381-5. doi: 10.1016/j.jen.2011.04.015. Epub 2011 May
      26.


PMID- 21620315
OWN - NLM
STAT- MEDLINE
DCOM- 20110823
LR  - 20220408
IS  - 1865-9217 (Print)
IS  - 1865-9217 (Linking)
VI  - 105
IP  - 4
DP  - 2011
TI  - Shared decision making in Brazil: history and current discussion.
PG  - 240-4
LID - 10.1016/j.zefq.2011.04.009 [doi]
AB  - There is no SDM in clinical practice in Brazil. The first steps have been taken
      towards research and tool development recently. Likewise, our society is starting
      to get involved with decision making in health care. This paper aims to offer an 
      overview of the Brazilian health system history, its values, and its influence on
      SDM. The participative social control concept is introduced as a result of the
      movement against the dictatorship era. In addition, the influence of social
      changes on the Medical Ethical Code is delineated. SDM state of the art in Brazil
      is also discussed and the challenges to implement it on clinical practice are
      described. Regardless the challenges, it is possible to make a positive
      assessment of SDM in Brazil.
CI  - 2011. Published by Elsevier GmbH.
FAU - Abreu, Mirhelen Mendes de
AU  - Abreu MM
AD  - Medicine Department, Federal University of Sao Carlos (UFSCar), Brazil.
      mirhelen@ufscar.br
FAU - Battisti, Raphael
AU  - Battisti R
FAU - Martins, Rachel Samhan
AU  - Martins RS
FAU - Baumgratz, Thiago Dias
AU  - Baumgratz TD
FAU - Cuziol, Mirella
AU  - Cuziol M
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110429
PL  - Netherlands
TA  - Z Evid Fortbild Qual Gesundhwes
JT  - Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen
JID - 101477604
SB  - IM
MH  - Brazil
MH  - Community Participation/*trends
MH  - Delivery of Health Care/*trends
MH  - Forecasting
MH  - Health Plan Implementation/trends
MH  - Health Policy/*trends
MH  - Humans
MH  - *Internationality
MH  - National Health Programs/trends
MH  - Patient Participation/*trends
MH  - Physician-Patient Relations
MH  - *Politics
MH  - Social Control, Formal
EDAT- 2011/05/31 06:00
MHDA- 2011/08/24 06:00
CRDT- 2011/05/31 06:00
PHST- 2011/05/31 06:00 [entrez]
PHST- 2011/05/31 06:00 [pubmed]
PHST- 2011/08/24 06:00 [medline]
AID - S1865-9217(11)00118-8 [pii]
AID - 10.1016/j.zefq.2011.04.009 [doi]
PST - ppublish
SO  - Z Evid Fortbild Qual Gesundhwes. 2011;105(4):240-4. doi:
      10.1016/j.zefq.2011.04.009. Epub 2011 Apr 29.


PMID- 21620311
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20220411
IS  - 1532-8635 (Electronic)
IS  - 1524-9042 (Linking)
VI  - 12
IP  - 2
DP  - 2011 Jun
TI  - Procedural pain management: a position statement with clinical practice
      recommendations.
PG  - 95-111
LID - 10.1016/j.pmn.2011.02.003 [doi]
AB  - The American Society for Pain Management Nursing (ASPMN) has developed a position
      statement and clinical practice recommendations related to procedural preparation
      and comfort management. Procedures potentially produce pain and anxiety, both of 
      which should be assessed and addressed before the procedure begins. This position
      statement refers to "comfort management" as incorporating the management of pain,
      anxiety, and any other discomforts that may occur with procedures. It is the
      position of ASPMN that nurses and other health care professionals advocate and
      intervene based on the needs of the patient, setting, and situation, to provide
      optimal comfort management before, during, and after procedures. Furthermore,
      ASPMN does not condone procedures being performed without the implementation of
      planned comfort assessment and management. In addition to outlining this position
      with supporting evidence, this paper reviews the ethical considerations regarding
      procedural comfort management and provides recommendations for nonpharmacologic
      and pharmacologic management during all phases of the procedure. An appendix
      provides a summary of this position statement and clinical practice
      recommendations.
CI  - Copyright (c) 2011 American Society for Pain Management Nursing. Published by
      Elsevier Inc. All rights reserved.
FAU - Czarnecki, Michelle L
AU  - Czarnecki ML
AD  - Jane B. Pettit Pain and Palliative Care Center, Children's Hospital of Wisconsin,
      Milwaukee, Wisconsin 53201, USA. mczarnecki@chw.org
FAU - Turner, Helen N
AU  - Turner HN
FAU - Collins, Patricia Manda
AU  - Collins PM
FAU - Doellman, Darcy
AU  - Doellman D
FAU - Wrona, Sharon
AU  - Wrona S
FAU - Reynolds, Janice
AU  - Reynolds J
LA  - eng
PT  - Journal Article
DEP - 20110429
PL  - United States
TA  - Pain Manag Nurs
JT  - Pain management nursing : official journal of the American Society of Pain
      Management Nurses
JID - 100890606
RN  - 0 (Analgesics)
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Anesthetics, Local)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
SB  - IM
MH  - Adult
MH  - Affective Symptoms/nursing/prevention & control
MH  - Analgesics/*therapeutic use
MH  - Analgesics, Opioid/therapeutic use
MH  - Anesthetics, Local/therapeutic use
MH  - Anti-Inflammatory Agents, Non-Steroidal/therapeutic use
MH  - Child
MH  - Humans
MH  - Infant, Newborn
MH  - Nurse-Patient Relations
MH  - Pain/*drug therapy/*nursing/psychology
MH  - *Practice Guidelines as Topic
MH  - Relaxation Therapy
MH  - Societies, Nursing/*standards
EDAT- 2011/05/31 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/05/31 06:00
PHST- 2011/02/04 00:00 [received]
PHST- 2011/02/23 00:00 [revised]
PHST- 2011/02/24 00:00 [accepted]
PHST- 2011/05/31 06:00 [entrez]
PHST- 2011/05/31 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - S1524-9042(11)00074-9 [pii]
AID - 10.1016/j.pmn.2011.02.003 [doi]
PST - ppublish
SO  - Pain Manag Nurs. 2011 Jun;12(2):95-111. doi: 10.1016/j.pmn.2011.02.003. Epub 2011
      Apr 29.


PMID- 21620085
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20131121
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 43
IP  - 4
DP  - 2011 May
TI  - Multiorgan retrieval and horseshoe kidney: case report.
PG  - 1190-2
LID - 10.1016/j.transproceed.2011.03.047 [doi]
AB  - Horseshoe kidney, a congenital anatomic condition with fusion of the kidney
      poles, causes the organ to be placed around the aorta usually below the origin of
      the mesenteric artery. This congenital disorder affects about 1 in 400 people.
      Retrieval for multiorgan transplantation dissects and canulates major abdominal
      vessels, aorta and vena cava, below the renal vessels to infuse refrigerated
      preservation solution. The presence of a horseshoe kidney could be a hazard for
      the retrieval team when cannulating when following standard techniques. We have
      described herein a surgical maneuver exposing the anterior surface of the aorta
      for canulation. We transected the horseshoe kidney in the midline with the use of
      a linear cutter stapler GIA 60 mm (Ethicon), after previously ligating both
      kidney pedicles. This technique was safely performed without the need for
      cannulation through the iliac vessels.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Pisaniello, D
AU  - Pisaniello D
AD  - Laparoscopic Hepatobiliary Surgical Unit, Liver Transplant Center AORN A,
      Cardarelli, Naples, Italy. dpisaniello@libero.it
FAU - Campanella, L
AU  - Campanella L
FAU - De Rosa, P
AU  - De Rosa P
FAU - Marcos, A
AU  - Marcos A
FAU - Cuomo, O
AU  - Cuomo O
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - 0 (Celsior)
RN  - 0 (Disaccharides)
RN  - 0 (Electrolytes)
RN  - 0 (Glutamates)
RN  - 0 (Organ Preservation Solutions)
RN  - 3OWL53L36A (Mannitol)
RN  - 4QD397987E (Histidine)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Accidents, Traffic
MH  - Adult
MH  - Aorta
MH  - *Brain Death
MH  - Cold Ischemia
MH  - Disaccharides/administration & dosage
MH  - Dissection
MH  - Electrolytes/administration & dosage
MH  - Glutamates/administration & dosage
MH  - Glutathione/administration & dosage
MH  - Histidine/administration & dosage
MH  - Humans
MH  - Kidney/abnormalities/blood supply/*surgery
MH  - Male
MH  - Mannitol/administration & dosage
MH  - Organ Preservation Solutions/*administration & dosage
MH  - *Organ Transplantation
MH  - Perfusion/*methods
MH  - Portal Vein
MH  - Tissue and Organ Harvesting/*methods
EDAT- 2011/05/31 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/05/31 06:00
PHST- 2011/05/31 06:00 [entrez]
PHST- 2011/05/31 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - S0041-1345(11)00519-7 [pii]
AID - 10.1016/j.transproceed.2011.03.047 [doi]
PST - ppublish
SO  - Transplant Proc. 2011 May;43(4):1190-2. doi: 10.1016/j.transproceed.2011.03.047.


PMID- 21620037
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20151119
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 43
IP  - 4
DP  - 2011 May
TI  - Preoperative psychological factors predicting graft rejection in patients
      undergoing kidney transplant: a pilot study.
PG  - 1006-9
LID - 10.1016/j.transproceed.2011.01.158 [doi]
AB  - BACKGROUND: The aim of this study was to investigate whether pretransplant
      psychological variables included in the CBA 2.0 Primary Scale-fear, personality, 
      obsessive-compulsive symptoms, state and trait anxiety, psychological reactions, 
      and depression-could predict graft rejection among patients undergoing kidney
      transplantation. METHODS: After ethical committee approval we enrolled 33
      consecutive adult patients undergoing kidney transplantation. The inclusion
      criteria were a stable clinical situation in an out-of-hospital setting; Italian 
      language literacy; a minimum of secondary school-level education, and written
      informed consent. We excluded patients with a psychotic disturbance,
      neurocognitive deficit, dementia, serious mental delay (IQ <50), current alcohol 
      or drug abuse, recent ideation or attempted suicide or nonadherence to the
      therapeutic protocol. Acute and/or chronic graft rejection was diagnosed
      according to clinical and histopathologic criteria. CBA-2,0 "Primary Scale"
      series of questionnaires were handed out to patients at the time of the
      examinations to discrem eligibility for transplantation. Analyses of variance
      were performed to compare psychological scores among patients with versus without
      graft rejection. Logistic regression analyses of psychological variables were
      performed to detect possible predictors for graft rejection. The results of the
      analysis showed that higher psychoticism scores were able to predict graft
      rejection (P<.05). RESULTS: The findings of this study suggest that it is
      mandatory to preoperatively plan an holistic treatment including psychological
      intervention mainly focused on psychoticism.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Calia, R
AU  - Calia R
AD  - Department of Psychiatry and Psychology, Catholic University of Sacred Heart,
      Rome, Italy.
FAU - Lai, C
AU  - Lai C
FAU - Aceto, P
AU  - Aceto P
FAU - Luciani, M
AU  - Luciani M
FAU - Saraceni, C
AU  - Saraceni C
FAU - Lai, S
AU  - Lai S
FAU - Gargiulo, A
AU  - Gargiulo A
FAU - Citterio, F
AU  - Citterio F
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Female
MH  - Graft Rejection/immunology/*psychology
MH  - Humans
MH  - Italy
MH  - Kidney Failure, Chronic/psychology/*surgery
MH  - Kidney Transplantation/immunology/*psychology
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Pilot Projects
MH  - Psychiatric Status Rating Scales
MH  - Risk Assessment
MH  - Risk Factors
MH  - Surveys and Questionnaires
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2011/05/31 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/05/31 06:00
PHST- 2011/05/31 06:00 [entrez]
PHST- 2011/05/31 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - S0041-1345(11)00242-9 [pii]
AID - 10.1016/j.transproceed.2011.01.158 [doi]
PST - ppublish
SO  - Transplant Proc. 2011 May;43(4):1006-9. doi: 10.1016/j.transproceed.2011.01.158.


PMID- 21620033
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20110530
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 43
IP  - 4
DP  - 2011 May
TI  - Ethical issues with nondirected ("good samaritan") kidney donation for
      transplantation.
PG  - 988-9
LID - 10.1016/j.transproceed.2011.01.146 [doi]
AB  - "Good samaritan" donation has been of great interest in Italy. At the request of 
      the Presidency of the Council of Ministers, the National Committee on Bioethics
      expressed its opinion on the matter. While highlighting its controversial
      aspects, the assessment was favorable. The National Council for Health
      established working criteria. Yet eminent bioethicists sharing the same values
      have reached discordant conclusions. Legal developments leading to the
      authorization of living donor kidney transplants from blood relatives or
      emotionally close individuals may offer a path for ethical assessment of the
      practice.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Petrini, C
AU  - Petrini C
AD  - Bioethics Unit, Istituto Superiore di Sanita, Rome, Italy. carlo.petrini@iss.it
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - *Altruism
MH  - Gift Giving/*ethics
MH  - Health Knowledge, Attitudes, Practice
MH  - Health Policy
MH  - Humans
MH  - Italy
MH  - Kidney Transplantation/adverse effects/*ethics/legislation & jurisprudence
MH  - Living Donors/*ethics/legislation & jurisprudence
MH  - Motivation
MH  - Nephrectomy/adverse effects/*ethics/legislation & jurisprudence
MH  - Risk Assessment
MH  - Tissue and Organ Procurement/*ethics/legislation & jurisprudence
EDAT- 2011/05/31 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/05/31 06:00
PHST- 2011/05/31 06:00 [entrez]
PHST- 2011/05/31 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - S0041-1345(11)00230-2 [pii]
AID - 10.1016/j.transproceed.2011.01.146 [doi]
PST - ppublish
SO  - Transplant Proc. 2011 May;43(4):988-9. doi: 10.1016/j.transproceed.2011.01.146.


PMID- 21620028
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20151119
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 43
IP  - 4
DP  - 2011 May
TI  - Extended criteria liver donation and transplant recipient consent: the European
      experience.
PG  - 971-3
LID - 10.1016/j.transproceed.2011.01.145 [doi]
AB  - The organization known as ELPAT (Ethical, Legal and Psychological Aspects of
      Organ Transplantation) coordinated the distribution of an electronic
      questionnaire concerning the definition of extended criteria liver donation (ECD)
      and the implication for informed consent of transplant recipients to European
      liver transplant centers. Completed questionnaires were received from 30 centers 
      in 13 countries. Twenty-eight centers accepted ECD liver donors. The criteria for
      defining a liver donor as ECD were: steatosis in 24 centers (85%); age up to 80
      years in 23 centers (82%); serum sodium levels higher than 165 mmol/L in 17
      centers (60%); intensive care unit stay with ventilation longer than 7 days in 16
      centers (57%); serum glutamic oxalo-acitic transaminase levels higher than 90 U/L
      in 12 centers (42%); body mass indeces more than 30 in 10 centers (35%); serum
      glutamic pyruvic transaminase levels higher than 105 U/L in 10 centers (35%);
      serum bilirubin levels higher than 3 mg/dL in 10 centers (35%); and other
      criteria in 13 centers (46%). Twenty-three centers informed the transplant
      candidate of the ECD status of the donor: 10 centers (43%) when the patient
      registered for transplantation, 3 centers (14%) when an ECD liver became
      available, and 10 centers (43%) on both occasions. Ten centers required the liver
      transplant candidate to sign a special consent form. Ten centers informed the
      potential recipient of the donor's serology. Only three centers informed the
      potential recipient of any high risk behavior of the donor.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Bruzzone, P
AU  - Bruzzone P
AD  - Sapienza Universita di Roma, Rome, Italy. paolo.bruzzone@fastwebnet.it
FAU - Giannarelli, D
AU  - Giannarelli D
FAU - Nunziale, A
AU  - Nunziale A
FAU - Manna, E
AU  - Manna E
FAU - Coiro, S
AU  - Coiro S
FAU - De Lucia, F
AU  - De Lucia F
FAU - Frattaroli, F M
AU  - Frattaroli FM
FAU - Pappalardo, G
AU  - Pappalardo G
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - 0 (Biomarkers)
SB  - IM
MH  - Access to Information
MH  - Age Factors
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - Body Mass Index
MH  - Critical Care
MH  - *Donor Selection/ethics
MH  - Europe
MH  - Fatty Liver/complications
MH  - Health Care Surveys
MH  - *Health Status
MH  - Humans
MH  - *Informed Consent
MH  - Length of Stay
MH  - *Liver Transplantation/adverse effects/ethics
MH  - Respiration, Artificial/adverse effects
MH  - Risk Assessment
MH  - Risk Factors
MH  - Surveys and Questionnaires
MH  - Tissue Donors/ethics/*supply & distribution
MH  - Treatment Outcome
EDAT- 2011/05/31 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/05/31 06:00
PHST- 2011/05/31 06:00 [entrez]
PHST- 2011/05/31 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - S0041-1345(11)00229-6 [pii]
AID - 10.1016/j.transproceed.2011.01.145 [doi]
PST - ppublish
SO  - Transplant Proc. 2011 May;43(4):971-3. doi: 10.1016/j.transproceed.2011.01.145.


PMID- 21619701
OWN - NLM
STAT- MEDLINE
DCOM- 20111206
LR  - 20211020
IS  - 1471-2431 (Electronic)
IS  - 1471-2431 (Linking)
VI  - 11
DP  - 2011 May 29
TI  - Health-related quality of life of young adults with Turner syndrome following a
      long-term randomized controlled trial of recombinant human growth hormone.
PG  - 49
LID - 10.1186/1471-2431-11-49 [doi]
AB  - BACKGROUND: There are limited long-term randomized controlled trials of growth
      hormone (GH) supplementation to adult height and few published reports of the
      health-related quality of life (HRQOL) following treatment. The present follow-up
      study of young adults from a long-term controlled trial of GH treatment in
      patients with Turner syndrome (TS) yielded data to examine whether GH
      supplementation resulted in a higher HRQOL (either due to taller stature or from 
      the knowledge that active treatment and not placebo had been received) or
      alternatively a lower HRQOL (due to medicalization from years of injections).
      METHODS: The original trial randomized 154 Canadian girls with TS aged 7-13 years
      from 13 centres to receive either long-term GH injections at the pharmacologic
      dose of 0.3 mg/kg/week or to receive no injections; estrogen prescription for
      induction of puberty was standardized. Patients were eligible for the follow-up
      study if they were at least 16 years old at the time of follow-up. The instrument
      used to study HRQOL was the SF-36, summarized into physical and mental component 
      scales (PCS and MCS); higher scores indicate better HRQOL. RESULTS: Thirty-four
      of the 48 eligible participants (71%) consented to participate; data were missing
      for one patient. Both groups (GH and no treatment) had normal HRQOL at this
      post-treatment assessment. The GH group had a (mean +/- SD) PCS score of 56 +/-
      5; the untreated group 58 +/- 4; mean score for 16-24 year old females in the
      general population 53.5 +/- 6.9. The GH group had a mean MCS score of 52 +/- 6;
      the untreated group 49 +/- 13; mean score for 16-24 year old females in the
      general population 49.6 +/- 9.8. Secondary analyses showed no relationship
      between HRQOL and height. CONCLUSIONS: We found no benefit or adverse effect on
      HRQOL either from receiving or not receiving growth hormone injections in a
      long-term randomized controlled trial, confirming larger observational studies.
      We suggest that it remains ethically acceptable as well as necessary to maintain 
      a long-term untreated control group to estimate the effects of pharmacological
      agents to manipulate adult height. Young adult women with TS have normal HRQOL
      suggesting that they adjust well to their challenges in life. TRIAL REGISTRATION:
      ClinicalTrials.gov Identifier NCT00191113.
FAU - Taback, Shayne P
AU  - Taback SP
AD  - Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, 
      R3T 2N2, Canada. tabacksp@cc.umanitoba.ca
FAU - Van Vliet, Guy
AU  - Van Vliet G
LA  - eng
SI  - ClinicalTrials.gov/NCT00191113
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110529
PL  - England
TA  - BMC Pediatr
JT  - BMC pediatrics
JID - 100967804
RN  - 0 (Estrogens)
RN  - 0 (Recombinant Proteins)
RN  - 12629-01-5 (Human Growth Hormone)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Estrogens/administration & dosage
MH  - Female
MH  - Follow-Up Studies
MH  - Human Growth Hormone/*administration & dosage/adverse effects
MH  - Humans
MH  - Puberty/drug effects
MH  - *Quality of Life
MH  - Recombinant Proteins/*administration & dosage/adverse effects
MH  - Time Factors
MH  - Treatment Outcome
MH  - Turner Syndrome/*drug therapy/psychology
MH  - Young Adult
PMC - PMC3125334
EDAT- 2011/05/31 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/05/31 06:00
PHST- 2010/07/20 00:00 [received]
PHST- 2011/05/29 00:00 [accepted]
PHST- 2011/05/31 06:00 [entrez]
PHST- 2011/05/31 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 1471-2431-11-49 [pii]
AID - 10.1186/1471-2431-11-49 [doi]
PST - epublish
SO  - BMC Pediatr. 2011 May 29;11:49. doi: 10.1186/1471-2431-11-49.


PMID- 21619673
OWN - NLM
STAT- MEDLINE
DCOM- 20111018
LR  - 20220330
IS  - 1750-1172 (Electronic)
IS  - 1750-1172 (Linking)
VI  - 6
DP  - 2011 May 28
TI  - Population pharmacokinetics and pharmacodynamics of hydroxyurea in sickle cell
      anemia patients, a basis for optimizing the dosing regimen.
PG  - 30
LID - 10.1186/1750-1172-6-30 [doi]
AB  - BACKGROUND: Hydroxyurea (HU) is the first approved pharmacological treatment of
      sickle cell anemia (SCA). The objectives of this study were to develop population
      pharmacokinetic(PK)-pharmacodynamic(PD) models for HU in order to characterize
      the exposure-efficacy relationships and their variability, compare two dosing
      regimens by simulations and develop some recommendations for monitoring the
      treatment. METHODS: The models were built using population modelling software
      NONMEM VII based on data from two clinical studies of SCA adult patients
      receiving 500-2000 mg of HU once daily. Fetal hemoglobin percentage (HbF%) and
      mean corpuscular volume (MCV) were used as biomarkers for response. A sequential 
      modelling approach was applied. Models were evaluated using simulation-based
      techniques. Comparisons of two dosing regimens were performed by simulating 10000
      patients in each arm during 12 months. RESULTS: The PK profiles were described by
      a bicompartmental model. The median (and interindividual coefficient of variation
      (CV)) of clearance was 11.6 L/h (30%), the central volume was 45.3 L (35%). PK
      steady-state was reached in about 35 days. For a given dosing regimen, HU
      exposure varied approximately fivefold among patients. The dynamics of HbF% and
      MCV were described by turnover models with inhibition of elimination of response.
      In the studied range of drug exposures, the effect of HU on HbF% was at its
      maximum (median Imax was 0.57, CV was 27%); the effect on MCV was close to its
      maximum, with median value of 0.14 and CV of 49%. Simulations showed that 95% of 
      the steady-state levels of HbF% and MCV need 26 months and 3 months to be
      reached, respectively. The CV of the steady-state value of HbF% was about 7 times
      larger than that of MCV. Simulations with two different dosing regimens showed
      that continuous dosing led to a stronger HbF% increase in some patients.
      CONCLUSIONS: The high variability of response to HU was related in part to
      pharmacokinetics and to pharmacodynamics. The steady-state value of MCV at month 
      3 is not predictive of the HbF% value at month 26. Hence, HbF% level may be a
      better biomarker for monitoring HU treatment. Continuous dosing might be more
      advantageous in terms of HbF% for patients who have a strong response to HU.
      TRIAL REGISTRATION: The clinical studies whose data are analysed and reported in 
      this work were not required to be registered in France at their time. Both
      studies were approved by local ethics committees (of Mondor Hospital and of
      Kremlin-Bicetre Hospital) and written informed consent was obtained from each
      patient.
FAU - Paule, Ines
AU  - Paule I
AD  - Universite de Lyon, Lyon, France.
FAU - Sassi, Hind
AU  - Sassi H
FAU - Habibi, Anoosha
AU  - Habibi A
FAU - Pham, Kim Pd
AU  - Pham KP
FAU - Bachir, Dora
AU  - Bachir D
FAU - Galacteros, Frederic
AU  - Galacteros F
FAU - Girard, Pascal
AU  - Girard P
FAU - Hulin, Anne
AU  - Hulin A
FAU - Tod, Michel
AU  - Tod M
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110528
PL  - England
TA  - Orphanet J Rare Dis
JT  - Orphanet journal of rare diseases
JID - 101266602
RN  - X6Q56QN5QC (Hydroxyurea)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anemia, Sickle Cell/*drug therapy
MH  - Computer Simulation
MH  - Drug Administration Schedule
MH  - Female
MH  - Humans
MH  - Hydroxyurea/blood/*pharmacokinetics/*pharmacology
MH  - Male
MH  - Middle Aged
MH  - Models, Biological
MH  - Young Adult
PMC - PMC3118100
EDAT- 2011/05/31 06:00
MHDA- 2011/10/19 06:00
CRDT- 2011/05/31 06:00
PHST- 2010/12/21 00:00 [received]
PHST- 2011/05/28 00:00 [accepted]
PHST- 2011/05/31 06:00 [entrez]
PHST- 2011/05/31 06:00 [pubmed]
PHST- 2011/10/19 06:00 [medline]
AID - 1750-1172-6-30 [pii]
AID - 10.1186/1750-1172-6-30 [doi]
PST - epublish
SO  - Orphanet J Rare Dis. 2011 May 28;6:30. doi: 10.1186/1750-1172-6-30.


PMID- 21618447
OWN - NLM
STAT- MEDLINE
DCOM- 20111121
LR  - 20110719
IS  - 1935-9780 (Electronic)
IS  - 1935-9772 (Linking)
VI  - 4
IP  - 4
DP  - 2011 Jul-Aug
TI  - Medical students' perceptions of the body donor as a "first patient" or
      "teacher": a pilot study.
PG  - 208-13
LID - 10.1002/ase.231 [doi]
AB  - University of Michigan Medical School (UMMS) students attending a seminar on the 
      history and ethics of anatomical dissection were fascinated by a report on the
      dissection room experience in Thailand that relates the body donor's status as a 
      teacher. The students felt that they had naturally adopted the "body as teacher" 
      approach in their dissection course, rather than the "body as first patient"
      approach that is encouraged by faculty. It was decided to explore the question
      whether other medical students shared these perceptions. A questionnaire was sent
      out to all UMMS students who had finished the anatomical dissection course. One
      hundred twenty-eight responses from a population of 500 students were received.
      Results indicate that students believe the "body as teacher" approach is more
      effective in engendering respect and empathy towards the body and towards future 
      patients, and in facilitating students' emotional development. Students also
      reported wanting a more personal relationship with their donors. Eighty four
      percent of students preferred the "body as teacher" approach to the currently
      taught "body as first patient" approach. The results support the hypothesis that 
      students' desired closer personal relationship with donors might be better
      facilitated by the "body as teacher" approach, and that this closer relationship 
      engenders empathy and respect towards the donor and future patients. A new model 
      for anatomy programs could introduce the donor first as a teacher and later
      transition into viewing the donor as a patient.
CI  - Copyright (c) 2011 American Association of Anatomists.
FAU - Bohl, Michael
AU  - Bohl M
AD  - University of Michigan Medical School, Ann Arbor, Michigan 48109-0608, USA.
FAU - Bosch, Peter
AU  - Bosch P
FAU - Hildebrandt, Sabine
AU  - Hildebrandt S
LA  - eng
PT  - Journal Article
DEP - 20110525
PL  - United States
TA  - Anat Sci Educ
JT  - Anatomical sciences education
JID - 101392205
SB  - IM
MH  - Anatomy/*education
MH  - *Cadaver
MH  - Humans
MH  - Perception
MH  - Pilot Projects
MH  - Students, Medical/*psychology
MH  - Teaching
MH  - Tissue Donors
EDAT- 2011/05/28 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/05/28 06:00
PHST- 2011/05/06 00:00 [received]
PHST- 2011/05/20 00:00 [accepted]
PHST- 2011/05/28 06:00 [entrez]
PHST- 2011/05/28 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1002/ase.231 [doi]
PST - ppublish
SO  - Anat Sci Educ. 2011 Jul-Aug;4(4):208-13. doi: 10.1002/ase.231. Epub 2011 May 25.


PMID- 21618362
OWN - NLM
STAT- MEDLINE
DCOM- 20120723
LR  - 20220317
IS  - 1536-4844 (Electronic)
IS  - 1078-0998 (Linking)
VI  - 18
IP  - 4
DP  - 2012 Apr
TI  - Fecal bacteriotherapy for ulcerative colitis: patients are ready, are we?
PG  - 676-84
LID - 10.1002/ibd.21775 [doi]
AB  - BACKGROUND: Fecal bacteriotherapy (FB) has been proposed as a safe and effective 
      alternative treatment for a number of gastrointestinal conditions including
      ulcerative colitis (UC). We performed a qualitative study to explore the
      attitudes and concerns of adult patients and parents of children with UC
      regarding FB as a potential treatment. METHODS: We conducted six focus groups for
      adult patients with UC and parents of children with UC or indeterminate colitis. 
      Participants were asked about their perceptions of and interest in FB as a
      treatment for UC. Sessions were recorded, transcribed, and reviewed to identify
      domains, themes, and major concepts. RESULTS: The focus groups included 15 adult 
      patients and seven parents of children with colitis. We identified five major
      domains pertaining to FB: impressions of treatment, benefits, risks, potential
      mechanisms, and social concerns. All but one participant expressed interest in FB
      and several wished it were already available. Participants compared FB to
      probiotics, felt it was "natural," easier than current therapies, and with donor 
      screening would be safe. Although initial distaste and the "yuck factor" were
      uniformly mentioned, these concerns were outweighed by perceived benefits.
      CONCLUSION: This is the first study to examine important ethical and social
      issues surrounding FB as a treatment for UC. Given adequate supporting research, 
      donor selection, and screening, adult patients and parents of children with UC
      will consider FB and are eager for it to become available. These findings have
      important implications for future microbiome-based treatments.
CI  - Copyright (c) 2011 Crohn's & Colitis Foundation of America, Inc.
FAU - Kahn, Stacy A
AU  - Kahn SA
AD  - University of Chicago, Inflammatory Bowel Disease Center, Department of
      Pediatrics, Section of Pediatric Gastroenterology, Hepatology, & Nutrition,
      MacLean Center for Clinical Medical Ethics, Chicago, Illinois 60637, USA.
      skahn@peds.bsd.uchicago.edu
FAU - Gorawara-Bhat, Rita
AU  - Gorawara-Bhat R
FAU - Rubin, David T
AU  - Rubin DT
LA  - eng
GR  - UL1 RR024999/RR/NCRR NIH HHS/United States
GR  - UL1 RR024999-03/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110525
PL  - England
TA  - Inflamm Bowel Dis
JT  - Inflammatory bowel diseases
JID - 9508162
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Attitude to Health
MH  - Child
MH  - Colitis, Ulcerative/*microbiology/psychology/*therapy
MH  - Feces/*microbiology
MH  - Female
MH  - Health Care Surveys
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Probiotics/therapeutic use
MH  - Severity of Illness Index
MH  - Young Adult
PMC - PMC3183116
MID - NIHMS290252
EDAT- 2011/05/28 06:00
MHDA- 2012/07/24 06:00
CRDT- 2011/05/28 06:00
PHST- 2011/04/14 00:00 [received]
PHST- 2011/04/18 00:00 [accepted]
PHST- 2011/05/28 06:00 [entrez]
PHST- 2011/05/28 06:00 [pubmed]
PHST- 2012/07/24 06:00 [medline]
AID - 10.1002/ibd.21775 [doi]
PST - ppublish
SO  - Inflamm Bowel Dis. 2012 Apr;18(4):676-84. doi: 10.1002/ibd.21775. Epub 2011 May
      25.


PMID- 21617733
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20220311
IS  - 1662-5145 (Electronic)
IS  - 1662-5145 (Linking)
VI  - 5
DP  - 2011
TI  - Deep brain stimulation in the media: over-optimistic portrayals call for a new
      strategy involving journalists and scientists in ethical debates.
PG  - 16
LID - 10.3389/fnint.2011.00016 [doi]
AB  - Deep brain stimulation (DBS) is optimistically portrayed in contemporary media.
      This already happened with psychosurgery during the first half of the twentieth
      century. The tendency of popular media to hype the benefits of DBS therapies,
      without equally highlighting risks, fosters public expectations also due to the
      lack of ethical analysis in the scientific literature. Media are not expected
      (and often not prepared) to raise the ethical issues which remain unaddressed by 
      the scientific community. To obtain a more objective portrayal of DBS in the
      media, a deeper collaboration between the science community and journalists, and 
      particularly specialized ones, must be promoted. Access to databases and
      articles, directly or through science media centers, has also been proven
      effective in increasing the quality of reporting. This article has three main
      objectives. Firstly, to explore the past media coverage of leukotomy, and to
      examine its widespread acceptance and the neglect of ethical issues in its
      depiction. Secondly, to describe how current enthusiastic coverage of DBS causes 
      excessive optimism and neglect of ethical issues in patients. Thirdly, to discuss
      communication models and strategies to enhance media and science responsibility.
FAU - Gilbert, Frederic
AU  - Gilbert F
AD  - Ethics and Bionics/Nanomedicine, Australian Centre of Excellence for
      Electromaterials Science, Faculty of Arts, University of Tasmania Launceston,
      Australia.
FAU - Ovadia, Daniela
AU  - Ovadia D
LA  - eng
PT  - Journal Article
DEP - 20110510
PL  - Switzerland
TA  - Front Integr Neurosci
JT  - Frontiers in integrative neuroscience
JID - 101477950
PMC - PMC3095813
OTO - NOTNLM
OT  - deep brain stimulation
OT  - mass media
OT  - neuroethics
OT  - neurosurgery
OT  - science journalism
EDAT- 2011/05/28 06:00
MHDA- 2011/05/28 06:01
CRDT- 2011/05/28 06:00
PHST- 2011/01/03 00:00 [received]
PHST- 2011/04/26 00:00 [accepted]
PHST- 2011/05/28 06:00 [entrez]
PHST- 2011/05/28 06:00 [pubmed]
PHST- 2011/05/28 06:01 [medline]
AID - 10.3389/fnint.2011.00016 [doi]
PST - epublish
SO  - Front Integr Neurosci. 2011 May 10;5:16. doi: 10.3389/fnint.2011.00016.
      eCollection 2011.


PMID- 21617655
OWN - NLM
STAT- MEDLINE
DCOM- 20111109
LR  - 20110527
IS  - 1476-5373 (Electronic)
IS  - 0007-0610 (Linking)
VI  - 210
IP  - 10
DP  - 2011 May 28
TI  - Animal ethics.
PG  - 463
LID - 10.1038/sj.bdj.2011.393 [doi]
FAU - Shah, H
AU  - Shah H
LA  - eng
PT  - Letter
PL  - England
TA  - Br Dent J
JT  - British dental journal
JID - 7513219
SB  - IM
MH  - *Animal Rights
MH  - Animals
MH  - Guided Tissue Regeneration, Periodontal/*ethics/methods
MH  - Humans
MH  - Periodontics/*ethics
MH  - Tissue and Organ Harvesting/*ethics
MH  - Tooth Germ
EDAT- 2011/05/28 06:00
MHDA- 2011/11/10 06:00
CRDT- 2011/05/28 06:00
PHST- 2011/05/28 06:00 [entrez]
PHST- 2011/05/28 06:00 [pubmed]
PHST- 2011/11/10 06:00 [medline]
AID - sj.bdj.2011.393 [pii]
AID - 10.1038/sj.bdj.2011.393 [doi]
PST - ppublish
SO  - Br Dent J. 2011 May 28;210(10):463. doi: 10.1038/sj.bdj.2011.393.


PMID- 21617625
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20110527
IS  - 1827-1596 (Electronic)
IS  - 0375-9393 (Linking)
VI  - 77
IP  - 6
DP  - 2011 Jun
TI  - Non-heart-beating organ donation in Italy.
PG  - 613-23
AB  - In 2007 the non-heart-beating organ donation (NHBD) "Programma Alba" (Sunrise
      Programme) started in Pavia, Italy. The initial plan was to cut down waiting list
      for kidney transplantation, while its final aim is to shorten organ
      transplantation waiting lists. When compared to European countries and the USA,
      the Italian NHBD program has taken longer to get established. Initially Italian
      physicians were not entirely aware of the NHBD organ viability for
      transplantation, furthermore ethical issues and the need to regulate medical
      requirements to Italian law slowed down the NHBD program. In particular, Italian 
      legislation provides for death ascertainment after irreversible cardiac arrest,
      20-minute flat electrocardiogram. This no-touch period is longer when compared to
      worldwide legislation, and organ viability has been a main concern for Italian
      transplant doctors over the years. However, recent data let up to 40-minute warm 
      ischemia time to preserve organ viability; this has encouraged Pavia's group to
      establish the NHBD "Programma Alba". It was designed according to Italian
      legislation from death diagnosis to graft placement, from this perspective must
      the significant role of the Transplant coordinator be recognized. Since 2007
      seven kidneys have been gathered from seven NHBD. Of these, six NHBD kidneys have
      been transplanted. Currently, four patients are out of dialysis. This report is a
      detailed description of NHBD "Programma Alba" and its preliminary results.
FAU - Geraci, P M
AU  - Geraci PM
AD  - Transplant Coordination Unit, Fondazione IRCCS Policlinico San Matteo, Camillo
      Golgi 19, Pavia, Italy. p.geraci@smatteo.pv.it
FAU - Sepe, V
AU  - Sepe V
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - Minerva Anestesiol
JT  - Minerva anestesiologica
JID - 0375272
SB  - IM
MH  - *Death, Sudden, Cardiac
MH  - Donor Selection/*standards
MH  - Extracorporeal Membrane Oxygenation
MH  - Humans
MH  - Italy
MH  - Tissue Donors/*classification
MH  - Tissue and Organ Procurement/*standards
EDAT- 2011/05/28 06:00
MHDA- 2011/11/09 06:00
CRDT- 2011/05/28 06:00
PHST- 2011/05/28 06:00 [entrez]
PHST- 2011/05/28 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - R02116269 [pii]
PST - ppublish
SO  - Minerva Anestesiol. 2011 Jun;77(6):613-23.


PMID- 21617623
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20131121
IS  - 1827-1596 (Electronic)
IS  - 0375-9393 (Linking)
VI  - 77
IP  - 6
DP  - 2011 Jun
TI  - A recruitment maneuver improves apneic oxygenation.
PG  - 598-603
AB  - BACKGROUND: Apneic oxygenation (AO) is applied during surgery and in intensive
      care units. Even with AO, apnea is associated with progressive hypoxemia,
      limiting the tolerable amount of time in AO. This experimental study evaluates
      the effects of a recruitment maneuver (RM) on oxygenation, CO2 retention, and
      survival times during prolonged apnea, supported or not supported with
      intratracheal apneic oxygenation. METHODS: Following Ethic Committee approval, 15
      male Sprague-Dawley rats were anesthetized and ventilated with PCV and FiO2:1 for
      15 minutes. After obtaining a basal arterial blood-gas sample, the rats were
      randomized into 3 groups and disconnected from the ventilator: group (G) 1
      (N.=6): AO with a cannula inserted into the carina; G2 (N=6): RM (40 cm H2O CPAP 
      applied for 30 seconds) before AO; and G3 (N.=3): no application after
      disconnection (G3 was stopped after the first 3 subjects died within 3 minutes). 
      Further arterial blood-gas samples were taken after 1, 3, and 6 minutes (T1, T3, 
      and T6). Survival times after the start of AO were recorded. RESULTS: G2 was
      associated with significantly higher values of PaO2 at T3 and T6 when compared to
      G1 (345+/-56 vs. 233+/-65 mm Hg at T3 and 258+/-31 vs. 180+/-31 mm Hg at T6,
      respectively, P<0.05). There were significant changes in PaO2, pH, and PaCO2 over
      time in all subjects, but no differences were observed between G1 and G2 in pH or
      PaCO2. Survival time in G2 was significantly longer as opposed to G1 (G1:
      10.3+/-2.3 min; G2: 14.3+/-3.6 min; P<0.05). CONCLUSION: RM prior to AO prolongs 
      tolerance to apnea, probably by increasing the time before intolerable hypoxemia 
      occurs, without a significant difference in PaCO2 levels.
FAU - Senturk, E
AU  - Senturk E
AD  - Department of Anesthesiology, Istanbul Medical Faculty, Istanbul University,
      Istanbul, Turkey. evrensenturk2@yahoo.com
FAU - Tanju, S
AU  - Tanju S
FAU - Ziyade, S
AU  - Ziyade S
FAU - Ozcan, P E
AU  - Ozcan PE
FAU - Tugrul, S
AU  - Tugrul S
FAU - Cakar, N
AU  - Cakar N
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Minerva Anestesiol
JT  - Minerva anestesiologica
JID - 0375272
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Animals
MH  - Apnea
MH  - Intraoperative Care/methods
MH  - Male
MH  - Oxygen/*metabolism
MH  - Pulmonary Alveoli/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2011/05/28 06:00
MHDA- 2011/11/09 06:00
CRDT- 2011/05/28 06:00
PHST- 2011/05/28 06:00 [entrez]
PHST- 2011/05/28 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - R02116264 [pii]
PST - ppublish
SO  - Minerva Anestesiol. 2011 Jun;77(6):598-603.


PMID- 21617510
OWN - NLM
STAT- MEDLINE
DCOM- 20110901
LR  - 20220317
IS  - 1938-808X (Electronic)
IS  - 1040-2446 (Linking)
VI  - 86
IP  - 7
DP  - 2011 Jul
TI  - Caring for underserved patients through neighborhood health screening: outcomes
      of a longitudinal, interprofessional, student-run home visit program in
      Singapore.
PG  - 829-39
LID - 10.1097/ACM.0b013e31821d841d [doi]
AB  - PURPOSE: Service learning, an effective vehicle for teaching undergraduate public
      health while providing underserved communities with medical care, is not well
      established in Asia. The authors evaluated a service learning program,
      Neighborhood Health Screening (NHS), in Singapore. METHOD: Medical and nursing
      undergraduate students provided in-home medical services to patients in a
      low-income neighborhood (January-June 2010). The authors assessed
      student-reported pedagogical effectiveness in nine domains, asked students for
      qualitative feedback on their experiences, assessed patients' satisfaction with
      NHS, and tracked clinical outcomes. RESULTS: Of the 240 medical and 34 nursing
      students who participated, 222 (93%) and 34 (100%), respectively, completed the
      questionnaire; 136 of the medical students (57%) also provided qualitative
      feedback. Most students felt NHS was beneficial across all domains. Male medical 
      students were less likely to report increased understanding of deficiencies in
      the health care system and long-term management of chronic disease; preclinical
      students were more likely to report improvements in comprehending ethical issues,
      critical thinking and action skills, and gaining and applying knowledge.
      Qualitative feedback supported quantitative findings. Patients were satisfied
      with NHS: 266 (75%) agreed that NHS improved their health, and 301 (85%) felt NHS
      provided sufficient time to address their issues. After a single year, amongst
      patients with known hypertension, treatment increased from 63% to 93% (P < .001),
      and blood pressure control amongst those who were on treatment improved from 42% 
      to 79% (P < .001). CONCLUSIONS: Service learning can make an important
      contribution to medical teaching and patient care in Asia.
FAU - Liang En, Wee
AU  - Liang En W
AD  - Yong Loo Lin School of Medicine, National University of Singapore, National
      University Health System, Singapore.
FAU - Koh, Gerald Choon-Huat
AU  - Koh GC
FAU - Lim, Vivien Kim Geok
AU  - Lim VK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Acad Med
JT  - Academic medicine : journal of the Association of American Medical Colleges
JID - 8904605
SB  - IM
MH  - Adult
MH  - Aged
MH  - Attitude of Health Personnel
MH  - Community-Institutional Relations
MH  - Diagnostic Tests, Routine/*methods
MH  - Education, Medical, Undergraduate/*methods
MH  - Education, Nursing/*methods
MH  - Female
MH  - *Home Care Services/organization & administration
MH  - Humans
MH  - Interprofessional Relations
MH  - Longitudinal Studies
MH  - Male
MH  - *Medically Underserved Area
MH  - Middle Aged
MH  - Patient Satisfaction
MH  - Preceptorship/*methods
MH  - Schools, Medical
MH  - Singapore
MH  - Students, Medical/psychology
MH  - Students, Nursing/psychology
MH  - Surveys and Questionnaires
EDAT- 2011/05/28 06:00
MHDA- 2011/09/02 06:00
CRDT- 2011/05/28 06:00
PHST- 2011/05/28 06:00 [entrez]
PHST- 2011/05/28 06:00 [pubmed]
PHST- 2011/09/02 06:00 [medline]
AID - 10.1097/ACM.0b013e31821d841d [doi]
PST - ppublish
SO  - Acad Med. 2011 Jul;86(7):829-39. doi: 10.1097/ACM.0b013e31821d841d.


PMID- 21617482
OWN - NLM
STAT- MEDLINE
DCOM- 20110810
LR  - 20210106
IS  - 1529-4242 (Electronic)
IS  - 0032-1052 (Linking)
VI  - 127
IP  - 6
DP  - 2011 Jun
TI  - Authorship and medical ghostwriting: Plastic and Reconstructive Surgery policy.
PG  - 2496-2500
LID - 10.1097/PRS.0b013e3182131aa6 [doi]
AB  - Authorship of biomedical articles serves to acknowledge and credit individuals
      who contributed substantially to the development, writing, and editing of
      articles. In addition, authorship indicates who is responsible for ideas and
      experiments, and can be used to hold people accountable if something is disproven
      or shown false. Types of authorship can be divided into four primary categories: 
      ghost authorship, guest authorship, gift authorship, and legitimate authorship.
      Of these four categories, Plastic and Reconstructive Surgery (along with other
      journals, the World Association of Medical Editors, the International Committee
      of Medical Journal Editors, the Council of Science Editors, and the Committee on 
      Publication Ethics) affirms that only authors who meet the criteria of
      "legitimate authorship" as authors should be listed on an article. This article
      discusses what constitutes legitimate article authorship and sets forth the
      Journal's policy on authorship.
FAU - Sullivan, Daniel
AU  - Sullivan D
AD  - Dallas, Texas From the Department of Plastic and Reconstructive Surgery,
      University of Texas Southwestern Medical Center, and the Editorial Office of
      Plastic and Reconstructive Surgery.
FAU - Rohrich, Rod J
AU  - Rohrich RJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Plast Reconstr Surg
JT  - Plastic and reconstructive surgery
JID - 1306050
SB  - IM
MH  - *Authorship
MH  - *Editorial Policies
MH  - *Periodicals as Topic
MH  - *Reconstructive Surgical Procedures
MH  - *Surgery, Plastic
EDAT- 2011/05/28 06:00
MHDA- 2011/08/11 06:00
CRDT- 2011/05/28 06:00
PHST- 2011/05/28 06:00 [entrez]
PHST- 2011/05/28 06:00 [pubmed]
PHST- 2011/08/11 06:00 [medline]
AID - 10.1097/PRS.0b013e3182131aa6 [doi]
AID - 00006534-201106000-00044 [pii]
PST - ppublish
SO  - Plast Reconstr Surg. 2011 Jun;127(6):2496-2500. doi:
      10.1097/PRS.0b013e3182131aa6.


PMID- 21617165
OWN - NLM
STAT- MEDLINE
DCOM- 20130227
LR  - 20121126
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 12
DP  - 2012 Dec
TI  - The morality of care: case study and review.
PG  - 763-4
LID - 10.1136/jme.2011.042911 [doi]
AB  - This case concerns aspects of the treatment of a post-surgical patient in a major
      public hospital in New Zealand during the author's experiences as a fourth year
      medical student. This case is used to consider the interlinked ethical issues of 
      sympathy, moral virtue, dignity and how the medical environment can realign these
      values.
FAU - Tatnell, Ryan
AU  - Tatnell R
AD  - Department of Psychological Medicine, Faculty of Medical and Health Sciences,
      University of Auckland, Private Bag, Auckland 92019, New Zealand.
FAU - Malpas, Phillipa J
AU  - Malpas PJ
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20110526
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
RN  - 0 (Narcotics)
SB  - IM
MH  - Beneficence
MH  - Colectomy
MH  - Emergency Treatment
MH  - *Empathy
MH  - *Ethics, Medical/education
MH  - Female
MH  - Humans
MH  - Internship and Residency/*ethics
MH  - *Moral Obligations
MH  - Narcotics/administration & dosage
MH  - New Zealand
MH  - Pain/drug therapy/etiology
MH  - *Personhood
MH  - Physician-Patient Relations/*ethics
MH  - Social Values
MH  - Surgical Wound Infection
MH  - Virtues
MH  - Young Adult
EDAT- 2011/05/28 06:00
MHDA- 2013/02/28 06:00
CRDT- 2011/05/28 06:00
PHST- 2011/05/28 06:00 [entrez]
PHST- 2011/05/28 06:00 [pubmed]
PHST- 2013/02/28 06:00 [medline]
AID - jme.2011.042911 [pii]
AID - 10.1136/jme.2011.042911 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Dec;38(12):763-4. doi: 10.1136/jme.2011.042911. Epub 2011 May 
      26.


PMID- 21616239
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20131121
IS  - 1531-5037 (Electronic)
IS  - 0022-3468 (Linking)
VI  - 46
IP  - 5
DP  - 2011 May
TI  - Custom dynamic stent for esophageal strictures in children.
PG  - 848-53
LID - 10.1016/j.jpedsurg.2011.02.014 [doi]
AB  - BACKGROUND: Esophageal stenting represents a new strategy to avoid multiple
      dilations owing to stenosis relapse. Our custom stent improves esophageal
      motility unlike the widespread self-expandable plastic esophageal stents. The aim
      of the study was to confirm the efficacy of treatment with silicone custom stents
      in esophageal stenosis (ES) in pediatric patients. METHODS: A silicone stent of
      7-, 9-, or 12.7-mm external diameter is built coaxially on a nasogastric tube
      that guarantees the correct position. The 2 ends are tailored to allow food
      passage between stent and esophageal wall. All patients received dexamethasone (2
      mg/kg per day) for 3 days and ranitidine/proton-pump inhibitors. Study approval
      was obtained from our ethical board. RESULTS: From 1988 to 2010, 79 patients with
      ES, mean age 35.4 months (3-125 months), underwent esophageal hydrostatic/Savary 
      dilations and custom-stent placement, left in place for at least 40 days.
      Stenting was effective in 70 (88.6%) of 79 patients. Fifty percent of the
      patients with effective treatment received only one dilation for stent placement.
      Fourteen patients received more stents successfully. There was one stent-related 
      major complication. CONCLUSION: Our custom stent improves treatment in ES. In
      caustic injuries, ES stenting represents the first option. In postsurgical ES, we
      stent after at least 5 dilations.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Foschia, Francesca
AU  - Foschia F
AD  - Digestive Surgery and Endoscopy Unit, Bambino Gesu Hospital, 00165 Rome, Italy.
      francesca.foschia@libero.it
FAU - De Angelis, Paola
AU  - De Angelis P
FAU - Torroni, Filippo
AU  - Torroni F
FAU - Romeo, Erminia
AU  - Romeo E
FAU - Caldaro, Tamara
AU  - Caldaro T
FAU - di Abriola, Giovanni Federici
AU  - di Abriola GF
FAU - Pane, Alessandro
AU  - Pane A
FAU - Fiorenza, Maria Stella
AU  - Fiorenza MS
FAU - De Peppo, Francesco
AU  - De Peppo F
FAU - Dall'Oglio, Luigi
AU  - Dall'Oglio L
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pediatr Surg
JT  - Journal of pediatric surgery
JID - 0052631
RN  - 0 (Caustics)
RN  - 0 (Proton Pump Inhibitors)
RN  - 7S5I7G3JQL (Dexamethasone)
SB  - IM
MH  - Antibiotic Prophylaxis
MH  - Burns, Chemical/therapy
MH  - Caustics/adverse effects
MH  - Child
MH  - Child, Preschool
MH  - Dexamethasone/administration & dosage/therapeutic use
MH  - Dilatation/*instrumentation
MH  - Equipment Design
MH  - Esophageal Motility Disorders/prevention & control
MH  - Esophageal Perforation/etiology
MH  - Esophageal Stenosis/chemically induced/etiology/*therapy
MH  - Female
MH  - Humans
MH  - Infant
MH  - Intubation, Gastrointestinal
MH  - Male
MH  - Postoperative Complications/therapy
MH  - Proton Pump Inhibitors/administration & dosage/therapeutic use
MH  - Radiation Injuries/therapy
MH  - *Stents/adverse effects
EDAT- 2011/05/28 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/05/28 06:00
PHST- 2011/01/28 00:00 [received]
PHST- 2011/02/11 00:00 [accepted]
PHST- 2011/05/28 06:00 [entrez]
PHST- 2011/05/28 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - S0022-3468(11)00126-6 [pii]
AID - 10.1016/j.jpedsurg.2011.02.014 [doi]
PST - ppublish
SO  - J Pediatr Surg. 2011 May;46(5):848-53. doi: 10.1016/j.jpedsurg.2011.02.014.


PMID- 21616238
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20171116
IS  - 1531-5037 (Electronic)
IS  - 0022-3468 (Linking)
VI  - 46
IP  - 5
DP  - 2011 May
TI  - Esophageal stenosis in epidermolysis bullosum: a challenge for the endoscopist.
PG  - 842-7
LID - 10.1016/j.jpedsurg.2011.02.017 [doi]
AB  - BACKGROUND/PURPOSE: Esophageal stenosis is a severe complication in dystrophic
      epidermolysis bullosa (EB). Endoscopic dilations may cause mucosal injury with
      stricture recurrence. Our aim was to describe our referral EB-center experience
      on safety and long-term efficacy of fluoroscopically guided balloon dilation
      without endoscopy. METHODS: Over 14 years, 34 patients with EB, previously
      evaluated with barium esophagogram for dysphagia, underwent balloon esophageal
      dilation. Under fluoroscopy, a guide wire was introduced via a nostril into the
      stomach. A 12-mm pneumatic balloon, which passed over the wire, was filled using 
      radio-opaque contrast, dilating the stricture. Orotracheal intubation was
      avoided. Antibiotics, dexamethasone, and proton-pump inhibitors were
      administered. Study approval was obtained from our ethical board. RESULTS:
      Ninety-three dilations were performed. Seventeen patients had a single stenosis. 
      The mean age of onset was 18 years (range, 3-47 years). Thirteen patients
      underwent one dilation. In 6 cases, endoscopy was necessary to visualize the
      esophageal lumen. Complications included cervical esophageal perforation (2) and 
      transitory dysphagia (10). Thirty patients were feeding within 24 hours. During
      the follow-up, 2 patients required a gastrostomy, and 2 patients underwent
      fundoplication for gastroesophageal reflux disease. CONCLUSIONS: Fluoroscopically
      guided balloon dilation in EB is a safe and well-tolerated procedure. An
      experienced endoscopy team is necessary in certain cases.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - De Angelis, Paola
AU  - De Angelis P
AD  - Digestive Surgery and Endoscopy Unit, Bambino Gesu Children's Hospital, IRCCS,
      00165, Rome, Italy. paoladeangelis.opbg@gmail.com
FAU - Caldaro, Tamara
AU  - Caldaro T
FAU - Torroni, Filippo
AU  - Torroni F
FAU - Romeo, Erminia
AU  - Romeo E
FAU - Foschia, Francesca
AU  - Foschia F
FAU - di Abriola, Giovanni Federici
AU  - di Abriola GF
FAU - Rea, Francesca
AU  - Rea F
FAU - El Hachem, May
AU  - El Hachem M
FAU - Genovese, Elisabetta
AU  - Genovese E
FAU - D'Alessandro, Sandra
AU  - D'Alessandro S
FAU - Dall'Oglio, Luigi
AU  - Dall'Oglio L
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pediatr Surg
JT  - Journal of pediatric surgery
JID - 0052631
RN  - 0 (Proton Pump Inhibitors)
RN  - 6OEV9DX57Y (Cefoxitin)
RN  - 7S5I7G3JQL (Dexamethasone)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antibiotic Prophylaxis
MH  - Catheterization/adverse effects/*methods
MH  - Cefoxitin/administration & dosage/therapeutic use
MH  - Child
MH  - Child, Preschool
MH  - Contraindications
MH  - Deglutition Disorders/etiology
MH  - Dexamethasone/administration & dosage/therapeutic use
MH  - Epidermolysis Bullosa/*complications
MH  - Esophageal Perforation/etiology
MH  - Esophageal Stenosis/etiology/surgery/*therapy
MH  - *Esophagoscopy
MH  - Female
MH  - Fluoroscopy
MH  - Gastrostomy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Preanesthetic Medication
MH  - Proton Pump Inhibitors/administration & dosage/therapeutic use
MH  - Radiography, Interventional
MH  - Young Adult
EDAT- 2011/05/28 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/05/28 06:00
PHST- 2011/01/28 00:00 [received]
PHST- 2011/02/11 00:00 [accepted]
PHST- 2011/05/28 06:00 [entrez]
PHST- 2011/05/28 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - S0022-3468(11)00129-1 [pii]
AID - 10.1016/j.jpedsurg.2011.02.017 [doi]
PST - ppublish
SO  - J Pediatr Surg. 2011 May;46(5):842-7. doi: 10.1016/j.jpedsurg.2011.02.017.


PMID- 21616173
OWN - NLM
STAT- MEDLINE
DCOM- 20111206
LR  - 20220309
IS  - 1559-2030 (Electronic)
IS  - 1551-7144 (Linking)
VI  - 32
IP  - 5
DP  - 2011 Sep
TI  - Oversight and management of a cell therapy clinical trial network: experience and
      lessons learned.
PG  - 614-9
LID - 10.1016/j.cct.2011.05.003 [doi]
AB  - The Cardiovascular Cell Therapy Research Network (CCTRN), sponsored by the
      National Heart, Lung, and Blood Institute (NHLBI), was established to develop,
      coordinate, and conduct multiple collaborative protocols testing the effects of
      cell therapy on cardiovascular diseases. The Network was born into a difficult
      political and ethical climate created by the recent removal of a dozen drugs from
      the US formulary and the temporary halting of 27 gene therapy trials due to
      safety concerns. This article describes the Network's challenges as it initiated 
      three protocols in a polarized cultural atmosphere at a time when oversight
      bodies were positioning themselves for the tightest vigilance of promising new
      therapies. Effective strategies involving ongoing education, open communication, 
      and relationship building with the oversight community are discussed.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Moye, Lemuel A
AU  - Moye LA
AD  - University of Texas School of Public Health, Houston, TX 77030, United States.
      Lemmoye@msn.com
FAU - Sayre, Shelly L
AU  - Sayre SL
FAU - Westbrook, Lynette
AU  - Westbrook L
FAU - Jorgenson, Beth C
AU  - Jorgenson BC
FAU - Handberg, Eileen
AU  - Handberg E
FAU - Anwaruddin, Saif
AU  - Anwaruddin S
FAU - Wagner, Kristi A
AU  - Wagner KA
FAU - Skarlatos, Sonia I
AU  - Skarlatos SI
LA  - eng
GR  - R01 HL091005/HL/NHLBI NIH HHS/United States
GR  - U01 HL087318/HL/NHLBI NIH HHS/United States
GR  - UM1 HL087318/HL/NHLBI NIH HHS/United States
GR  - UM1 HL087366/HL/NHLBI NIH HHS/United States
GR  - U01 HL087318-01/HL/NHLBI NIH HHS/United States
PT  - Journal Article
DEP - 20110517
PL  - United States
TA  - Contemp Clin Trials
JT  - Contemporary clinical trials
JID - 101242342
SB  - IM
MH  - Cardiovascular Diseases/*therapy
MH  - Cell- and Tissue-Based Therapy/*ethics/methods
MH  - Clinical Trials Data Monitoring Committees
MH  - *Community Networks
MH  - *Ethics Committees, Research
MH  - *Ethics, Research
MH  - Humans
MH  - *Safety
MH  - United States
MH  - United States Food and Drug Administration
PMC - PMC3157886
MID - NIHMS304167
EDAT- 2011/05/28 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/05/28 06:00
PHST- 2010/10/13 00:00 [received]
PHST- 2011/05/03 00:00 [revised]
PHST- 2011/05/11 00:00 [accepted]
PHST- 2011/05/28 06:00 [entrez]
PHST- 2011/05/28 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S1551-7144(11)00108-X [pii]
AID - 10.1016/j.cct.2011.05.003 [doi]
PST - ppublish
SO  - Contemp Clin Trials. 2011 Sep;32(5):614-9. doi: 10.1016/j.cct.2011.05.003. Epub
      2011 May 17.


PMID- 21616116
OWN - NLM
STAT- MEDLINE
DCOM- 20111209
LR  - 20220321
IS  - 1873-2518 (Electronic)
IS  - 0264-410X (Linking)
VI  - 29
IP  - 35
DP  - 2011 Aug 11
TI  - A systematic review of experimental infections with enterotoxigenic Escherichia
      coli (ETEC).
PG  - 5869-85
LID - 10.1016/j.vaccine.2011.05.021 [doi]
AB  - Volunteer challenge with enterotoxigenic Escherichia coli (ETEC) has been used
      for four decades to elucidate the pathogenesis and immune responses and assess
      efficacy of various interventions. We performed a systematic review of these
      studies and a meta-analysis of individual patient-level data (IPD) from a subset 
      of studies using standard methodology. We identified 27 studies of 11 ETEC
      strains administered to 443 naive subjects at doses from 1x10(6) to 1x10(10)
      colony forming units (cfu). Diarrhea attack rates varied by strain, dose and
      enterotoxin. Similar rates were seen at doses of 5x10(8) to 1x10(10)cfu with the 
      three most commonly used strains B7A, E24377A, H10407. In IPD analysis, the
      highest diarrhea attack rates were seen with strains B7A, H10407 and E24377A. The
      H10407 induced significantly higher stool output than the other strains.
      Additionally, the rate of output was different across strains. The risk of
      diarrhea, abdominal cramps, nausea and headaches differed significantly by ETEC
      strain. An increased risk of nausea, abdominal cramps and headaches was seen for 
      females. Baseline anti-LT IgG titers appeared to be associated with a decrease
      risk of diarrhea outcomes, a trend not seen with anti-LT IgA or seen consistently
      with anti-colonization factor antibodies. Neither early antibiotic treatment nor 
      diarrhea duration significantly affected the frequency or magnitude of serologic 
      responses. These studies have served as an invaluable tool in understanding
      disease course, pathogenicity, innate immune responses and an early assessment of
      product efficacy. When designing and planning experimental ETEC infection studies
      in this age of increased ethical scrutiny and growing appreciation of
      post-infectious sequelae, better understanding of available data is essential.
CI  - Published by Elsevier Ltd.
FAU - Porter, Chad K
AU  - Porter CK
AD  - Naval Medical Research Center, Enteric Diseases Department, Silver Spring, MD,
      United States. chad.porter@med.navy.mil
FAU - Riddle, Mark S
AU  - Riddle MS
FAU - Tribble, David R
AU  - Tribble DR
FAU - Louis Bougeois, A
AU  - Louis Bougeois A
FAU - McKenzie, Robin
AU  - McKenzie R
FAU - Isidean, Sandra D
AU  - Isidean SD
FAU - Sebeny, Peter
AU  - Sebeny P
FAU - Savarino, Stephen J
AU  - Savarino SJ
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20110525
PL  - Netherlands
TA  - Vaccine
JT  - Vaccine
JID - 8406899
RN  - 0 (Antibodies, Bacterial)
SB  - IM
MH  - Adult
MH  - Antibodies, Bacterial/blood
MH  - *Clinical Trials as Topic
MH  - Diarrhea/immunology/microbiology/physiopathology
MH  - Enterotoxigenic Escherichia coli/classification/*pathogenicity
MH  - Escherichia coli Infections/*immunology/microbiology/*physiopathology
MH  - Female
MH  - *Human Experimentation
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Virulence
MH  - Young Adult
EDAT- 2011/05/28 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/05/28 06:00
PHST- 2011/02/10 00:00 [received]
PHST- 2011/05/04 00:00 [revised]
PHST- 2011/05/09 00:00 [accepted]
PHST- 2011/05/28 06:00 [entrez]
PHST- 2011/05/28 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - S0264-410X(11)00731-6 [pii]
AID - 10.1016/j.vaccine.2011.05.021 [doi]
PST - ppublish
SO  - Vaccine. 2011 Aug 11;29(35):5869-85. doi: 10.1016/j.vaccine.2011.05.021. Epub
      2011 May 25.


PMID- 21616035
OWN - NLM
STAT- MEDLINE
DCOM- 20110719
LR  - 20110527
IS  - 1448-7527 (Print)
IS  - 1448-7527 (Linking)
VI  - 17
IP  - 1
DP  - 2011
TI  - Researcher development program of the primary health care research, evaluation
      and development strategy.
PG  - 114-21
LID - 10.1071/PY10049 [doi]
AB  - The Research Development Program (RDP) was initiated in 2004 under the Primary
      Health Care Research, Evaluation and Development (PHCRED) Strategy to increase
      the number and range of people with knowledge and skills in primary health care
      research and evaluation. RDP Fellows were invited to participate in an online
      survey about the effect the program had on their research knowledge, attitudes
      and practice. The response rate was 42% (105/248). Most were female (88%) with
      66% aged between 31 and 50 years. Over two-thirds (72%) were health
      practitioners. Activities undertaken during the RDP ranged from literature
      reviews, developing a research question, preparing ethics submissions, attending 
      and presenting at conferences and seminars, preparing papers and reports, and
      submitting grant applications. Despite the fact that only 52% agreed that the RDP
      time was adequate, 94% agreed that the RDP was a valuable experience, with 89%
      expressing interest in undertaking further research. These results indicate that 
      this program has had a positive effect on the RDP Fellows in terms of their
      knowledge about research, their attitude to research, and the way they use
      research in their work.
FAU - McIntyre, Ellen
AU  - McIntyre E
AD  - Primary Health Care Research and Information Service, Discipline of General
      Practice, Flinders University, GPO Box 2100, Adelaide, SA 5000, Australia.
      ellen.mcintyre@flinders.edu.au
FAU - Brun, Lyn
AU  - Brun L
FAU - Cameron, Helen
AU  - Cameron H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Aust J Prim Health
JT  - Australian journal of primary health
JID - 101123037
SB  - IM
MH  - Adult
MH  - Australia
MH  - *Fellowships and Scholarships
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Health Services Research
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Primary Health Care
MH  - Program Development
MH  - Program Evaluation
MH  - Research/*education
EDAT- 2011/05/28 06:00
MHDA- 2011/07/20 06:00
CRDT- 2011/05/28 06:00
PHST- 2010/08/19 00:00 [received]
PHST- 2011/01/31 00:00 [accepted]
PHST- 2011/05/28 06:00 [entrez]
PHST- 2011/05/28 06:00 [pubmed]
PHST- 2011/07/20 06:00 [medline]
AID - PY10049 [pii]
AID - 10.1071/PY10049 [doi]
PST - ppublish
SO  - Aust J Prim Health. 2011;17(1):114-21. doi: 10.1071/PY10049.


PMID- 21616016
OWN - NLM
STAT- MEDLINE
DCOM- 20110719
LR  - 20131121
IS  - 1448-7527 (Print)
IS  - 1448-7527 (Linking)
VI  - 17
IP  - 1
DP  - 2011
TI  - Prescribing for the elderly: ethical considerations.
PG  - 2-3
LID - 10.1071/PY10052 [doi]
AB  - This article reports on a few ethical considerations associated with prescribing 
      for the elderly. A large number of elderly people are on several medications for 
      the treatment of various chronic conditions that develop with age. Most of these 
      treatments involve symptom management and prevention of symptoms likely to occur 
      from untreated diseases. Serious consideration should be given when prescribing
      for the elderly. These include: allowing the elderly and their families to be
      involved in their treatment; social support; and cost-benefit considerations. A
      lack of clear therapeutic guidelines exists for prescribing in this group of
      people that is confounded by factors such as quality of life and life expectancy.
FAU - Khalil, Hanan
AU  - Khalil H
LA  - eng
PT  - Letter
PL  - Australia
TA  - Aust J Prim Health
JT  - Australian journal of primary health
JID - 101123037
SB  - IM
MH  - Aged
MH  - Drug Therapy/economics/*ethics
MH  - Drug-Related Side Effects and Adverse Reactions
MH  - Geriatric Assessment
MH  - Humans
MH  - Life Expectancy
MH  - Polypharmacy
MH  - Quality of Life
EDAT- 2011/05/28 06:00
MHDA- 2011/07/20 06:00
CRDT- 2011/05/28 06:00
PHST- 2010/08/30 00:00 [received]
PHST- 2010/10/17 00:00 [accepted]
PHST- 2011/05/28 06:00 [entrez]
PHST- 2011/05/28 06:00 [pubmed]
PHST- 2011/07/20 06:00 [medline]
AID - PY10052 [pii]
AID - 10.1071/PY10052 [doi]
PST - ppublish
SO  - Aust J Prim Health. 2011;17(1):2-3. doi: 10.1071/PY10052.


PMID- 21615638
OWN - NLM
STAT- MEDLINE
DCOM- 20130429
LR  - 20220321
IS  - 1369-7625 (Electronic)
IS  - 1369-6513 (Linking)
VI  - 15
IP  - 4
DP  - 2012 Dec
TI  - Close to the bench as well as at the bedside: involving service users in all
      phases of translational research.
PG  - 389-400
LID - 10.1111/j.1369-7625.2011.00681.x [doi]
AB  - AIM: The paper aims to develop a model of translational research in which service
      user and other stakeholder involvement are central to each phase. BACKGROUND:
      'Translational' is the current medical buzzword: translational research has been 
      termed 'bench to bedside' research and promises to fast-track biomedical advances
      in the service of patient benefit. Models usually conceive of translational
      research as a 'pipeline' that is divided into phases: the early phase is
      characterized as the province of basic scientists and laboratory-based clinical
      researchers; the later phases focus on the implementation, dissemination and
      diffusion of health applications. If service user involvement is mentioned, it is
      usually restricted to these later phases. METHODS: The paper critically reviews
      existing literature on translational research and medicine. The authors develop a
      theoretical argument that addresses why a reconceptualization of translational
      research is required on scientific, ethical and pragmatic grounds. RESULTS: The
      authors reconceptualize the model of translational research as an interlocking
      loop rather than as a pipeline, one in which service user and other stakeholder
      involvement feed into each of its elements. The authors demonstrate that for the 
      'interlocking loop' model of translational research to be materialized in
      practice will require changes in how health research is structured and organized.
      CONCLUSION: The authors demonstrate the scientific, ethical and pragmatic
      benefits of involving service users in every phase of translational research. The
      authors' reconceptualized model of translational research contributes to
      theoretical and policy debates regarding both translational research and service 
      user involvement.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Callard, Felicity
AU  - Callard F
AD  - Stakeholder Participation Theme, NIHR Biomedical Research Centre for Mental
      Health, South London and Maudsley NHS Foundation Trust and Institute of
      Psychiatry, King's College London, London,, UK. felicity.callard@kcl.ac.uk
FAU - Rose, Diana
AU  - Rose D
FAU - Wykes, Til
AU  - Wykes T
LA  - eng
GR  - 086049/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110525
PL  - England
TA  - Health Expect
JT  - Health expectations : an international journal of public participation in health 
      care and health policy
JID - 9815926
RN  - 0 (Biomarkers)
SB  - IM
MH  - Biomarkers
MH  - Clinical Trials as Topic
MH  - *Cooperative Behavior
MH  - Humans
MH  - Information Dissemination
MH  - Organizational Innovation
MH  - Patient Participation/*methods
MH  - Research Personnel/*organization & administration
MH  - Translational Research, Biomedical/ethics/*organization & administration
PMC - PMC5060629
EDAT- 2011/05/28 06:00
MHDA- 2013/04/30 06:00
CRDT- 2011/05/28 06:00
PHST- 2011/05/28 06:00 [entrez]
PHST- 2011/05/28 06:00 [pubmed]
PHST- 2013/04/30 06:00 [medline]
AID - 10.1111/j.1369-7625.2011.00681.x [doi]
PST - ppublish
SO  - Health Expect. 2012 Dec;15(4):389-400. doi: 10.1111/j.1369-7625.2011.00681.x.
      Epub 2011 May 25.


PMID- 21615233
OWN - NLM
STAT- MEDLINE
DCOM- 20111220
LR  - 20131121
IS  - 1651-2006 (Electronic)
IS  - 1401-7431 (Linking)
VI  - 45
IP  - 4
DP  - 2011 Aug
TI  - Measurement of intraperitoneal metabolites during hypothermic cardiopulmonary
      bypass using microdialysis.
PG  - 229-35
LID - 10.3109/14017431.2011.572995 [doi]
AB  - OBJECTIVE: Splanchnic hypoxia, with resultant mucosal acidosis during
      cardiopulmonary bypass (CPB) has been demonstrated using tonometry. Microdialysis
      is a minimally-invasive method of obtaining peritoneal fluid samples. We measured
      the intraperitoneal metabolites during peri-operative period following
      hypothermic CPB and studied the safety of intraperitoneal microdialysis. DESIGN: 
      Eleven consecutive patients undergoing coronary artery bypass grafting (CABG)
      were included after obtaining ethics committee approval and informed consent.
      Microdialysis catheters were placed intraperitoneally after sternotomy.
      Intraperitoneal samples and arterial blood samples were obtained peri-operatively
      for first 24 hours. The samples were analysed for levels of glucose, lactate,
      pyruvate and glycerol. Repeated measures ANOVA test was used to compare timed
      serum and intraperitoneal samples. RESULTS: The study population included nine
      males and two females with a mean age of 63.7 +/- 11 years. The mean CPB and X
      clamp times were 50.9 +/- 7.3 minutes and 27.3 +/- 4.9 minutes, respectively.
      There were no complications related to microdialysis. The intraperitoneal lactate
      (L), pyruvate (P) and glycerol increased during CPB and four to six hours
      postoperatively. The L:P ratio was >10:1 during CPB, but in the postoperative
      period showed evidence of impaired oxygen utilisation. CONCLUSIONS: This
      prospective study confirms incidence of intraperitoneal anaerobic metabolism of
      glucose during CPB and impaired utilisation of glucose in the postoperative
      period. Microdialysis provides a novel and minimally-invasive method to measure
      real time intraperitoneal events.
FAU - Adluri, Rajeshwara K P
AU  - Adluri RK
AD  - Department of Cardiac Surgery, The Trent Cardiac Centre, Nottingham City Hospital
      NHS Trust, Nottingham, UK. arkrishnap@yahoo.com
FAU - Singh, Arvind V
AU  - Singh AV
FAU - Skoyles, Julian
AU  - Skoyles J
FAU - Baker, Mya
AU  - Baker M
FAU - Mitchell, Ian M
AU  - Mitchell IM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110526
PL  - England
TA  - Scand Cardiovasc J
JT  - Scandinavian cardiovascular journal : SCJ
JID - 9708377
RN  - 0 (Blood Glucose)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 8558G7RUTR (Pyruvic Acid)
RN  - PDC6A3C0OX (Glycerol)
SB  - IM
MH  - Aged
MH  - Ascitic Fluid/*metabolism
MH  - Blood Glucose/*metabolism
MH  - *Cardiopulmonary Bypass
MH  - Female
MH  - Glycerol/blood
MH  - Humans
MH  - *Hypothermia, Induced
MH  - Lactic Acid/blood
MH  - Male
MH  - Microdialysis
MH  - Middle Aged
MH  - Postoperative Complications
MH  - Prospective Studies
MH  - Pyruvic Acid/blood
EDAT- 2011/05/28 06:00
MHDA- 2011/12/21 06:00
CRDT- 2011/05/28 06:00
PHST- 2011/05/28 06:00 [entrez]
PHST- 2011/05/28 06:00 [pubmed]
PHST- 2011/12/21 06:00 [medline]
AID - 10.3109/14017431.2011.572995 [doi]
PST - ppublish
SO  - Scand Cardiovasc J. 2011 Aug;45(4):229-35. doi: 10.3109/14017431.2011.572995.
      Epub 2011 May 26.


PMID- 21615006
OWN - NLM
STAT- MEDLINE
DCOM- 20110615
LR  - 20211203
IS  - 0279-1072 (Print)
IS  - 0279-1072 (Linking)
VI  - 43
IP  - 1
DP  - 2011 Jan-Mar
TI  - Yopo, ethnicity and social change: a comparative analysis of Piaroa and Cuiva
      yopo uset.
PG  - 36-45
LID - 10.1080/02791072.2011.566499 [doi]
AB  - Most Orinocoan ethnic groups, including the Cuiva and the Piaroa, use yopo, a
      hallucinogenic snuff derived from the seeds of the Anadenanthera peregrina tree. 
      This study contrasts Piaroa and Cuiva attitudes toward and uses of yopo in light 
      of ongoing processes of social change. We do not believe that these sociocultural
      forces will lead to a phasing out of yopo in Piaroa and Cuiva life. However, we
      demonstrate how, in nearby communities, a combination of historical and ethical
      contingencies lead to very different patterns and understanding of drug use. Yopo
      is strongly associated with the performance of narratives central to each ethnic 
      group's cosmology and identity. Cuiva yopo consumption is also a means of
      resisting persecution and asserting the right to a just reality. Piaroa attitudes
      towards yopo are affected by the interplay of shamanic ethical principles and
      missionary activity, and are sometimes paradoxical: yopo is the reason for harm
      and the means of salvation; required by shamans to create the future and yet
      regarded by many laypeople as a relic of the past. We identify persecution, local
      responses to missionary activity, and shamanic ethics as key factors affecting
      the evolution of hallucinogen use by Amazonian ethnic groups.
FAU - Rodd, Robin
AU  - Rodd R
AD  - School of Anthropology, Archaeology and Sociology, James Cook University,
      Townsville, Australia. robin.rodd@jcu.edu.au
FAU - Sumabila, Arelis
AU  - Sumabila A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Psychoactive Drugs
JT  - Journal of psychoactive drugs
JID - 8113536
RN  - 0 (Hallucinogens)
SB  - IM
MH  - Christianity
MH  - Colombia
MH  - Colonialism
MH  - Culture
MH  - *Ethnicity
MH  - *Hallucinogens
MH  - Humans
MH  - *Indians, South American
MH  - Legislation, Drug
MH  - Religion
MH  - Shamanism
MH  - *Social Change
MH  - Substance-Related Disorders/*epidemiology
MH  - Venezuela
EDAT- 2011/05/28 06:00
MHDA- 2011/06/16 06:00
CRDT- 2011/05/28 06:00
PHST- 2011/05/28 06:00 [entrez]
PHST- 2011/05/28 06:00 [pubmed]
PHST- 2011/06/16 06:00 [medline]
AID - 10.1080/02791072.2011.566499 [doi]
PST - ppublish
SO  - J Psychoactive Drugs. 2011 Jan-Mar;43(1):36-45. doi:
      10.1080/02791072.2011.566499.


PMID- 21613888
OWN - NLM
STAT- MEDLINE
DCOM- 20110804
LR  - 20110526
IS  - 1938-808X (Electronic)
IS  - 1040-2446 (Linking)
VI  - 86
IP  - 6
DP  - 2011 Jun
TI  - Commentary: Balancing responsibility to patients and responsibility to aspiring
      physicians with disabilities.
PG  - 674-6
LID - 10.1097/ACM.0b013e318217e956 [doi]
AB  - In 2008, Congress amended the Americans with Disabilities Act (ADA) to relax
      court-imposed limitations on evidence required to warrant protection under the
      ADA. Since passage of the ADA in 1990, medicine has focused not on evaluating the
      types of accommodations that would best balance the interests of individuals with
      disabilities, institutions, and patients but, rather, on the question of whether 
      individuals seeking protection under the law qualify for disability
      accommodations at all. The medical profession should refocus on the nature of
      accommodations provided to those with disabilities. In doing so, the intent to
      support disabled persons seeking careers in medicine must be balanced with
      ethical obligations to protect patient welfare. Medical schools, graduate medical
      education programs, licensing and certifying authorities, and assessment
      organizations should work together to establish evidence-based minimum criteria
      for the physical and cognitive capabilities required of every physician.
FAU - Melnick, Donald E
AU  - Melnick DE
AD  - National Board of Medical Examiners, 3750 Market Street, Philadelphia, PA 19104, 
      USA. dmelnick@nbme.org
LA  - eng
PT  - Comment
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Acad Med
JT  - Academic medicine : journal of the Association of American Medical Colleges
JID - 8904605
SB  - IM
CON - Acad Med. 2011 Jun;86(6):768-72. PMID: 21512367
MH  - *Civil Rights/legislation & jurisprudence
MH  - *Disabled Persons/legislation & jurisprudence
MH  - *Education, Medical/ethics/legislation & jurisprudence
MH  - Educational Measurement
MH  - Ethics, Medical
MH  - Humans
MH  - *Social Responsibility
MH  - United States
EDAT- 2011/05/27 06:00
MHDA- 2011/08/05 06:00
CRDT- 2011/05/27 06:00
PHST- 2011/05/27 06:00 [entrez]
PHST- 2011/05/27 06:00 [pubmed]
PHST- 2011/08/05 06:00 [medline]
AID - 10.1097/ACM.0b013e318217e956 [doi]
AID - 00001888-201106000-00011 [pii]
PST - ppublish
SO  - Acad Med. 2011 Jun;86(6):674-6. doi: 10.1097/ACM.0b013e318217e956.


PMID- 21613647
OWN - NLM
STAT- MEDLINE
DCOM- 20120301
LR  - 20111019
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 11
DP  - 2011 Nov
TI  - Justification for a home-based education programme for kidney patients and their 
      social network prior to initiation of renal replacement therapy.
PG  - 677-81
LID - 10.1136/jme.2011.042366 [doi]
AB  - In this article, an ethical analysis of an educational programme on renal
      replacement therapy options for patients and their social network is presented.
      The two main spearheads of this approach are: (1) offering an educational
      programme on all renal replacement therapy options ahead of treatment requirement
      and (2) a home-based approach involving the family and friends of the patient.
      Arguments are offered for the ethical justification of this approach by
      considering the viewpoint of the various stakeholders involved. Finally,
      reflecting on these ethical considerations, essential conditions for carrying out
      such a programme are outlined. The goal is to develop an ethically justified and 
      responsible educational programme.
FAU - Massey, Emma K
AU  - Massey EK
AD  - Department of Internal Medicine, Kidney Transplant Unit, Erasmus MC, Room D-408, 
      Postbus 2040, 3000 CA Rotterdam, The Netherlands. e.massey@erasmusmc.nl
FAU - Hilhorst, Medard T
AU  - Hilhorst MT
FAU - Nette, Robert W
AU  - Nette RW
FAU - Smak Gregoor, Peter J H
AU  - Smak Gregoor PJ
FAU - van den Dorpel, Marinus A
AU  - van den Dorpel MA
FAU - van Kooij, Anthony C
AU  - van Kooij AC
FAU - Zuidema, Willij C
AU  - Zuidema WC
FAU - Zietse, R
AU  - Zietse R
FAU - Busschbach, Jan J V
AU  - Busschbach JJ
FAU - Weimar, Willem
AU  - Weimar W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110525
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Family/psychology
MH  - Friends/psychology
MH  - Humans
MH  - Kidney Failure, Chronic/psychology/*therapy
MH  - Living Donors/*psychology
MH  - Netherlands
MH  - Patient Education as Topic/*methods/standards
MH  - Renal Replacement Therapy/methods/*psychology
MH  - Risk Factors
MH  - *Social Support
MH  - Time Factors
MH  - Tissue and Organ Procurement
EDAT- 2011/05/27 06:00
MHDA- 2012/03/02 06:00
CRDT- 2011/05/27 06:00
PHST- 2011/05/27 06:00 [entrez]
PHST- 2011/05/27 06:00 [pubmed]
PHST- 2012/03/02 06:00 [medline]
AID - jme.2011.042366 [pii]
AID - 10.1136/jme.2011.042366 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Nov;37(11):677-81. doi: 10.1136/jme.2011.042366. Epub 2011 May
      25.


PMID- 21613441
OWN - NLM
STAT- MEDLINE
DCOM- 20120227
LR  - 20151119
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 260
IP  - 3
DP  - 2011 Sep
TI  - Congenital heart disease: cardiovascular MR imaging by using an intravascular
      blood pool contrast agent.
PG  - 680-8
LID - 10.1148/radiol.11102327 [doi]
AB  - PURPOSE: To compare the image quality and diagnostic performance of a contrast
      agent-specific inversion-recovery (IR) steady-state free precession (SSFP)
      magnetic resonance (MR) imaging sequence performed by using an intravascular
      contrast agent (gadofosveset trisodium) with those of a commonly used T2-prepared
      SSFP sequence performed by using an extravascular (gadopentetate dimeglumine) and
      an intravascular (gadofosveset trisodium) contrast agent in patients with
      congenital heart disease (CHD). MATERIALS AND METHODS: The local ethics committee
      and the United Kingdom Medicines and Healthcare products Regulatory Agency
      approved this study. Patient informed consent was obtained. Twenty-three patients
      with CHD were examined by using a 1.5-T MR imaging unit and a 32-channel coil.
      Gadopentetate dimeglumine and gadofosveset trisodium were used in the same
      patient on consecutive days. Vessel wall sharpness, contrast-to-noise ratios
      (CNRs), image quality, and diagnostic performance achieved by using the IR SSFP
      sequence with gadofosveset trisodium were compared with those achieved by using
      the T2-prepared SSFP sequence with gadopentetate dimeglumine and gadofosveset
      trisodium and with those achieved at respective contrast material-enhanced MR
      angiographic examinations. The Wilcoxon rank sum test was used to compare
      categoric variables; t tests were used to compare continuous variables. RESULTS: 
      Use of the IR SSFP sequence with gadofosveset trisodium significantly improved
      vessel wall sharpness, CNRs, and image quality (P < .05 for all) for all
      investigated intra- and extracardiac structures compared with the T2-prepared
      SSFP sequence with gadopentetate dimeglumine and gadofosveset trisodium and the
      respective contrast-enhanced MR angiographic examinations. With use of the IR
      SSFP sequence with gadofosveset trisodium, new, unsuspected diseases (five [22%] 
      of 23) were diagnosed, while other diseases could be excluded (15 [65%] of 23).
      Information available from echocardiography (n = 23), conventional angiography (n
      = 4), and/or surgery (n = 1) confirmed all diagnoses. CONCLUSION: IR SSFP with
      gadofosveset trisodium improved image quality and diagnostic performance,
      allowing a more accurate and complete assessment of cardiovascular anatomy in
      patients with CHD compared with T2-prepared SSFP with gadopentetate dimeglumine
      and gadofosveset trisodium and respective contrast-enhanced MR angiographic
      examinations.
FAU - Makowski, Marcus R
AU  - Makowski MR
AD  - Division of Imaging Sciences, King's College London British Heart Foundation
      Centre, Biomedical Research Centre of Guy's and St. Thomas' Hospital, King's
      College London, National Health Service Foundation Trust, Lambeth Place Road,
      London SE1 7EH, England.
FAU - Wiethoff, Andrea J
AU  - Wiethoff AJ
FAU - Uribe, Sergio
AU  - Uribe S
FAU - Parish, Victoria
AU  - Parish V
FAU - Botnar, Rene M
AU  - Botnar RM
FAU - Bell, Aaron
AU  - Bell A
FAU - Kiesewetter, Christoph
AU  - Kiesewetter C
FAU - Beerbaum, Philipp
AU  - Beerbaum P
FAU - Jansen, Christian H P
AU  - Jansen CH
FAU - Razavi, Reza
AU  - Razavi R
FAU - Schaeffter, Tobias
AU  - Schaeffter T
FAU - Greil, Gerald F
AU  - Greil GF
LA  - eng
GR  - Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110525
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - AU0V1LM3JT (Gadolinium)
RN  - XM33Q67UVH (gadofosveset trisodium)
SB  - IM
MH  - Adult
MH  - Contrast Media/administration & dosage
MH  - Female
MH  - *Gadolinium/administration & dosage
MH  - Heart Defects, Congenital/*diagnosis
MH  - Humans
MH  - Image Enhancement/*methods
MH  - Injections, Intra-Arterial
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - *Organometallic Compounds/administration & dosage
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Young Adult
EDAT- 2011/05/27 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/05/27 06:00
PHST- 2011/05/27 06:00 [entrez]
PHST- 2011/05/27 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - radiol.11102327 [pii]
AID - 10.1148/radiol.11102327 [doi]
PST - ppublish
SO  - Radiology. 2011 Sep;260(3):680-8. doi: 10.1148/radiol.11102327. Epub 2011 May 25.


PMID- 21613439
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20111117
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 260
IP  - 2
DP  - 2011 Aug
TI  - Comparative prospective randomized study comparing conservative treatment and
      percutaneous disk decompression for treatment of intervertebral disk herniation.
PG  - 487-93
LID - 10.1148/radiol.11101094 [doi]
AB  - PURPOSE: To compare short-, intermediate-, and long-term functional results
      concerning pain reduction and mobility improvement between conservative therapy
      and percutaneous disk decompression (PDD) in patients with intervertebral disk
      herniations. MATERIALS AND METHODS: The study received approval from both the
      university ethics panel and the institutional review board. Patients provided
      informed consent for the study. Over the past 4 years, two randomized groups of
      31 patients with sciatica due to intervertebral disk herniation were
      prospectively studied and compared with the t test. The control group underwent
      conservative therapy (administration of analgesics, antiinflammatory drugs,
      muscle relaxants, and physiotherapy) for 6 weeks. The decompression group
      underwent fluoroscopically guided PDD. Pain reduction and mobility improvement
      were recorded at 3-, 12-, and 24-month follow-up on a numeric visual scale (NVS) 
      (range, 0-10). RESULTS: The control group had a mean pain score of 6.9 NVS units 
      +/- 1.9 prior to conservative therapy. This was reduced to 0.9 NVS units +/- 2.0 
      3 months after therapy; however, it increased to 4.0 NVS units +/- 3.4 at
      12-month follow-up and further increased to 4.0 NVS units +/- 3.4 at 24-month
      follow-up. The decompression group had a mean pain score of 7.4 NVS units +/- 1.4
      prior to PDD. This was reduced to 3.0 NVS units +/- 2.4 at 3-month follow-up and 
      further reduced to 1.7 NVS units +/- 2.4 at 12-month follow-up and 1.6 NVS units 
      +/- 2.5 at 24-month follow-up. No complications were noted. CONCLUSION: When
      compared with conservative therapy, PDD shows improved amelioration of symptoms
      at 12- and 24-month follow-up.
CI  - (c) RSNA, 2011.
FAU - Erginousakis, Dimitrios
AU  - Erginousakis D
AD  - 2nd Radiology Department, University General Hospital Attikon, 1 Rimini St,
      Haidari 12462, Athens, Greece.
FAU - Filippiadis, Dimitrios K
AU  - Filippiadis DK
FAU - Malagari, Aikaterini
AU  - Malagari A
FAU - Kostakos, Athanasios
AU  - Kostakos A
FAU - Brountzos, Elias
AU  - Brountzos E
FAU - Kelekis, Nikolaos L
AU  - Kelekis NL
FAU - Kelekis, Alexis
AU  - Kelekis A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20110525
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Analgesics)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Neuromuscular Agents)
SB  - IM
MH  - Adult
MH  - Analgesics/therapeutic use
MH  - Anti-Inflammatory Agents, Non-Steroidal/therapeutic use
MH  - Decompression, Surgical
MH  - Female
MH  - Humans
MH  - Intervertebral Disc Displacement/surgery/*therapy
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Neuromuscular Agents/therapeutic use
MH  - Pain Measurement
MH  - Physical Therapy Modalities
MH  - Prospective Studies
MH  - Treatment Outcome
EDAT- 2011/05/27 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/05/27 06:00
PHST- 2011/05/27 06:00 [entrez]
PHST- 2011/05/27 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - radiol.11101094 [pii]
AID - 10.1148/radiol.11101094 [doi]
PST - ppublish
SO  - Radiology. 2011 Aug;260(2):487-93. doi: 10.1148/radiol.11101094. Epub 2011 May
      25.


PMID- 21612659
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1471-2326 (Electronic)
IS  - 1471-2326 (Linking)
VI  - 11
DP  - 2011 May 26
TI  - Serum levels of leptin in Nigerian patients with sickle cell anaemia.
PG  - 2
LID - 10.1186/1471-2326-11-2 [doi]
AB  - BACKGROUND: Several studies have shown that the pathophysiology of homozygous
      sickle cell anaemia (SCA) results in a myriad of metabolic, nutritional,
      haematological and clinical effects that interact with other co-morbid factors to
      determine the quality of life and life expectancy of afflicted patients. Because 
      of its critical roles in nutrition and metabolism, inflammation, haematopoiesis
      and cellular immunity, this study determined the plasma levels of leptin in
      steady and unsteady states of HbSS in Nigerian patients. METHODS: A total of 51
      SCA patients aged 5 - 35 years with 34 (61.8%) being females who were either on
      admission or visiting four medical centres in Lagos, Nigeria together with 22
      non-SCD controls aged 5 -30 years comprising 12 (54.5%) females were enrolled
      after obtaining their informed consent and ethical approval. Patients were
      further stratified into steady and unsteady cases of SCA based on clinical
      presentations, while blood samples collected by venipuncture from each of the
      study participants were analyzed haematologically for full blood count and HbF
      level and microscopically for malaria, while plasma leptin was assayed using
      ELISA method. Body composition defined by weight, fat mass and body mass index
      (BMI) was determined using standard methods. Data obtained for cases and controls
      were analyzed statistically. RESULTS: Twenty - one patients had unsteady HbSS and
      elicited greater and significant (P < 0.05) reduction in fat mass, BMI, HbF and
      eosinophil count but elevated mean total leukocyte, count, level of irreversibly 
      sickled cells and P. falciparum parasitaemia (4613.7 vs. 749.6 - 1078.4
      parasites/uL), pyrexia rate (58.3 vs. 25.8%) when compared with steady state
      patients or non-SCD controls. Compared to the control, significant decreases in
      plasma leptin before and after controlling for body fat that was worsened by
      crisis were observed among the SCD patients. Unlike the non-SCD controls, leptin 
      correlated non-significantly (P > 0.05) with all body composition indices
      measured in the patients except for fat mass in unsteady cases. Multivariate
      regression analysis identified ESR and RC as independent predictor of low plasma 
      leptin concentration in the SCA patients. CONCLUSIONS: Base on these findings, we
      conclude that plasma level of leptin is further decreased in the unsteady state
      of HbSS, shows poor correlation with adiposity and malarial infection but has
      inflammation and poor reticulocyte response as independent predictors among
      Nigerian patients.
FAU - Iwalokun, Bamidele A
AU  - Iwalokun BA
AD  - Department of Biochemistry and Nutrition, Nigerian Institute of Medical Research,
      Yaba, Lagos, Nigeria. bamwal@yahoo.com.
FAU - Iwalokun, Senapon O
AU  - Iwalokun SO
FAU - Hodonu, Semande O
AU  - Hodonu SO
FAU - Aina, Ayoola O
AU  - Aina AO
FAU - Agomo, Phillip U
AU  - Agomo PU
LA  - eng
PT  - Journal Article
DEP - 20110526
PL  - England
TA  - BMC Blood Disord
JT  - BMC blood disorders
JID - 100968550
PMC - PMC3125216
EDAT- 2011/05/27 06:00
MHDA- 2011/05/27 06:01
CRDT- 2011/05/27 06:00
PHST- 2010/10/21 00:00 [received]
PHST- 2011/05/26 00:00 [accepted]
PHST- 2011/05/27 06:00 [entrez]
PHST- 2011/05/27 06:00 [pubmed]
PHST- 2011/05/27 06:01 [medline]
AID - 1471-2326-11-2 [pii]
AID - 10.1186/1471-2326-11-2 [doi]
PST - epublish
SO  - BMC Blood Disord. 2011 May 26;11:2. doi: 10.1186/1471-2326-11-2.


PMID- 21612619
OWN - NLM
STAT- MEDLINE
DCOM- 20111107
LR  - 20211020
IS  - 1758-2652 (Electronic)
IS  - 1758-2652 (Linking)
VI  - 14
DP  - 2011 May 25
TI  - HIV treatment for prevention.
PG  - 28
LID - 10.1186/1758-2652-14-28 [doi]
AB  - "No virus, no transmission." Studies have repeatedly shown that viral load (the
      quantity of virus present in blood and sexual secretions) is the strongest
      predictor of HIV transmission during unprotected sex or transmission from
      infected mother to child. Effective treatment lowers viral load to undetectable
      levels. If one could identify and treat all HIV-infected people immediately after
      infection, the HIV/AIDS epidemic would eventually disappear.Such a radical
      solution is currently unrealistic. In reality, not all people get tested,
      especially when they fear stigma and discrimination. Thus, not all HIV-infected
      individuals are known. Of those HIV-positive individuals for whom the diagnosis
      is known, not all of them have access to therapy, agree to be treated, or are
      taking therapy effectively. Some on effective treatment will stop, and in others,
      the development of resistance will lead to treatment failure. Furthermore,
      resources are limited: should we provide drugs to asymptomatic HIV-infected
      individuals without indication for treatment according to guidelines in order to 
      prevent HIV transmission at the risk of diverting funding from sick patients in
      urgent need? In fact, the preventive potential of anti-HIV drugs is unknown.
      Modellers have tried to fill the gap, but models differ depending on assumptions 
      that are strongly debated. Further, indications for antiretroviral treatments
      expand; in places like Vancouver and San Francisco, the majority of HIV-positive 
      individuals are now under treatment, and the incidence of new HIV infections has 
      recently fallen. However, correlation does not necessarily imply causation.
      Finally, studies in couples where one partner is HIV-infected also appear to show
      that treatment reduces the risk of transmission.More definite studies, where a
      number of communities are randomized to either receive the "test-and-treat"
      approach or continue as before, are now in evaluation by funding agencies.
      Repeated waves of testing would precisely measure the incidence of HIV infection.
      Such trials face formidable logistical, practical and ethical obstacles. However,
      without definitive data, the intuitive appeal of "test-and-treat" is unlikely to 
      translate into action on a global scale. In the meantime, based on the available 
      evidence, we must strive to provide treatment to all those in medical need under 
      the current medical guidelines. This will lead to a decrease in HIV transmission 
      while "test-and-treat" is fully explored in prospective clinical trials.
FAU - Ambrosioni, Juan
AU  - Ambrosioni J
AD  - HIV Unit, Department of Infectious Diseases, University of Geneva Hospitals,
      Geneva, Switzerland.
FAU - Calmy, Alexandra
AU  - Calmy A
FAU - Hirschel, Bernard
AU  - Hirschel B
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110525
PL  - Switzerland
TA  - J Int AIDS Soc
JT  - Journal of the International AIDS Society
JID - 101478566
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - Anti-HIV Agents/*therapeutic use
MH  - Antiretroviral Therapy, Highly Active
MH  - HIV Infections/*drug therapy/*prevention & control/transmission
MH  - Humans
PMC - PMC3123616
EDAT- 2011/05/27 06:00
MHDA- 2011/11/08 06:00
CRDT- 2011/05/27 06:00
PHST- 2010/10/05 00:00 [received]
PHST- 2011/05/25 00:00 [accepted]
PHST- 2011/05/27 06:00 [entrez]
PHST- 2011/05/27 06:00 [pubmed]
PHST- 2011/11/08 06:00 [medline]
AID - 1758-2652-14-28 [pii]
AID - 10.1186/1758-2652-14-28 [doi]
PST - epublish
SO  - J Int AIDS Soc. 2011 May 25;14:28. doi: 10.1186/1758-2652-14-28.


PMID- 21612165
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20110526
IS  - 0883-5381 (Print)
IS  - 0883-5381 (Linking)
VI  - 26
IP  - 3
DP  - 2011 May-Jun
TI  - 7 factors complicate ethical resource allocation decisions: we should be more
      aware of the issues most likely to produce conflicts.
PG  - 62-3
FAU - Hofmann, Paul B
AU  - Hofmann PB
AD  - Hofmann Healthcare Group, USA. hofmann@hofmannhealth.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Healthc Exec
JT  - Healthcare executive
JID - 8612808
MH  - *Decision Making, Organizational
MH  - Guidelines as Topic
MH  - Health Facilities/economics
MH  - Health Facility Administrators
MH  - Humans
MH  - Professional Competence
MH  - Resource Allocation/*ethics
MH  - United States
EDAT- 2011/05/27 06:00
MHDA- 2011/06/29 06:00
CRDT- 2011/05/27 06:00
PHST- 2011/05/27 06:00 [entrez]
PHST- 2011/05/27 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
PST - ppublish
SO  - Healthc Exec. 2011 May-Jun;26(3):62-3.


PMID- 21612164
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20110526
IS  - 0883-5381 (Print)
IS  - 0883-5381 (Linking)
VI  - 26
IP  - 3
DP  - 2011 May-Jun
TI  - Ethical wisdom: doing the right thing, every day, everywhere in the organization.
PG  - 30-2, 34-5
FAU - Squazzo, Jessica D
AU  - Squazzo JD
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Healthc Exec
JT  - Healthcare executive
JID - 8612808
MH  - *Codes of Ethics
MH  - Health Facility Administrators/*ethics
MH  - Humans
MH  - Leadership
MH  - Organizational Culture
MH  - Organizational Policy
MH  - United States
EDAT- 2011/05/27 06:00
MHDA- 2011/06/29 06:00
CRDT- 2011/05/27 06:00
PHST- 2011/05/27 06:00 [entrez]
PHST- 2011/05/27 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
PST - ppublish
SO  - Healthc Exec. 2011 May-Jun;26(3):30-2, 34-5.


PMID- 21612111
OWN - NLM
STAT- MEDLINE
DCOM- 20110616
LR  - 20110525
IS  - 0024-3477 (Print)
IS  - 0024-3477 (Linking)
VI  - 133
IP  - 3-4
DP  - 2011 Mar-Apr
TI  - [Ethics of scientific research using patients' archived biological material and
      their medical data].
PG  - 133-9
AB  - Informed consent represents the standard for adequate protection of all
      participants in biomedical research. This standard is affirmed in international
      legal documents concerning biomedical research, as well as in Croatian
      legislation. However, some questions regarding informed consent remain open. One 
      of such questions that research ethics committees around the world and in the
      Republic of Croatia often deal with, is the question of whether to obtain
      informed consent for the research on archived material or previously collected
      research data taken from the patients during diagnostic or therapeutic
      procedures. This contribution provides an overview of both Croatian and
      international legal documents and guidelines that deal with this issue, together 
      with an overview of the literature concerning this issue. Since in the Republic
      of Croatia there are no regulations regarding this type of research, the authors 
      of this contribution are presenting conduct guidelines for researchers and ethics
      committees in such cases. The implementation of the proposed guidelines would
      facilitate scientific research and international cooperation for Croatian
      scientific institutions.
FAU - Borovecki, Ana
AU  - Borovecki A
AD  - Skola narodnog zdravlja Andrija Stampar, Medicinski fakultet, Sveuciliste u
      Zagrebu, Rockefellerova 4, 10000 Zagreb.
FAU - Bradamante, Vlasta
AU  - Bradamante V
FAU - Simonovic, Dubravka
AU  - Simonovic D
FAU - Babic-Bosanac, Sanja
AU  - Babic-Bosanac S
LA  - hrv
PT  - English Abstract
PT  - Journal Article
TT  - Eticki pristup znanstvenim istrazivanjima u kojima se koriste pohranjeni bioloski
      materijali pacijenata i njihovi medicinski podatci.
PL  - Croatia
TA  - Lijec Vjesn
JT  - Lijecnicki vjesnik
JID - 0074253
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Croatia
MH  - Humans
MH  - Informed Consent/*ethics
MH  - *Medical Records
MH  - Tissue Banks/*ethics
EDAT- 2011/05/27 06:00
MHDA- 2011/06/17 06:00
CRDT- 2011/05/27 06:00
PHST- 2011/05/27 06:00 [entrez]
PHST- 2011/05/27 06:00 [pubmed]
PHST- 2011/06/17 06:00 [medline]
PST - ppublish
SO  - Lijec Vjesn. 2011 Mar-Apr;133(3-4):133-9.


PMID- 21604941
OWN - NLM
STAT- MEDLINE
DCOM- 20110830
LR  - 20220309
IS  - 1651-226X (Electronic)
IS  - 0284-186X (Linking)
VI  - 50 Suppl 1
DP  - 2011 Jun
TI  - Pathology in prostate research: optimizing tissue quality.
PG  - 53-5
LID - 10.3109/0284186X.2010.525224 [doi]
AB  - The collection of tissue from the prostate gland for research creates unique
      challenges in the identification of cancer and in preserving pathological
      material. VALUE AND USES OF FORMALIN FIXED TISSUE: Formalin fixed paraffin
      embedded (FFPE) tissue is often available in abundance after pathological
      processing and reporting of specimens but is limited in value for detailed
      molecular tests. Tissue micro-array if carefully performed is a helpful technique
      for examining many FFPE specimens with immunohistochemical or fluorescence in
      situ hybridization tests. VALUE AND USES OF FROZEN TISSUE: The collection of
      fresh tissue prior to formalin fixation and later validation samples of fresh
      prostate cancer is difficult as prostate cancer is very difficult to identify
      macroscopically on cut prostate specimens. Also, the act of manipulation and
      dissection of the gland while fresh and without compromising surgical margins is 
      challenging. Methods which have been used to dissect the fresh prostate gland and
      also collect fresh tissue from other prostatic specimens are discussed. The
      ethical challenges of collecting research tissue without compromising patient
      care are discussed. CONCLUSIONS: Prostate cancer tissue banks, particularly of
      frozen tissue are still relatively few in number. Enhanced collection methods
      which do not prohibit full pathological examination are available but require
      expertise to maximize their potential.
FAU - Berney, Daniel M
AU  - Berney DM
AD  - Department of Molecular Oncology and Imaging, Institute of Cancer, Queen Mary
      University of London, London, UK. D.Berney@bartsandthelondon.nhs.uk
FAU - Montironi, Rodolfo
AU  - Montironi R
FAU - Egevad, Lars
AU  - Egevad L
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Acta Oncol
JT  - Acta oncologica (Stockholm, Sweden)
JID - 8709065
SB  - IM
MH  - Biomedical Research
MH  - Humans
MH  - Male
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Prostatic Neoplasms/*pathology
MH  - *Quality Control
MH  - Tissue Banks/*standards
EDAT- 2011/05/27 06:00
MHDA- 2011/08/31 06:00
CRDT- 2011/05/25 06:00
PHST- 2011/05/25 06:00 [entrez]
PHST- 2011/05/27 06:00 [pubmed]
PHST- 2011/08/31 06:00 [medline]
AID - 10.3109/0284186X.2010.525224 [doi]
PST - ppublish
SO  - Acta Oncol. 2011 Jun;50 Suppl 1:53-5. doi: 10.3109/0284186X.2010.525224.


PMID- 21611821
OWN - NLM
STAT- MEDLINE
DCOM- 20120209
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 17
IP  - 2
DP  - 2011 Jun
TI  - Overview: underserved areas of education in the responsible conduct of research: 
      authorship.
PG  - 335-9
LID - 10.1007/s11948-011-9281-3 [doi]
AB  - In February of 2007, the Responsible Conduct of Research Education Committee of
      the Association for Practical and Professional Ethics convened a mini-conference 
      at the Association's annual meeting. The purpose of the mini-conference was to
      examine underserved areas of education in research ethics. The mini-conference
      consisted of panel discussions for two topics: authorship and social
      responsibility. Representatives from diverse academic disciplines were invited to
      participate in each of the two panels. This Special Section of Science and
      Engineering Ethics consists of the papers based on presentations in the
      authorship panel. The papers illustrate similarities and differences in
      authorship and publication practices in various disciplines including
      engineering, the life sciences, and the social sciences.
FAU - Kalichman, Michael W
AU  - Kalichman MW
AD  - Research Ethics Program, University of California, 9500 Gilman Drive, San Diego, 
      La Jolla, CA 92093-0612, USA. kalichman@ucsd.edu
LA  - eng
GR  - R01 NR009962/NR/NINR NIH HHS/United States
PT  - Congress
DEP - 20110526
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Authorship
MH  - Engineering/*education/ethics
MH  - *Ethics, Professional
MH  - Ethics, Research/*education
MH  - Science/*education/ethics
MH  - Scientific Misconduct
MH  - United States
PMC - PMC3428198
MID - NIHMS396574
EDAT- 2011/05/26 06:00
MHDA- 2012/02/10 06:00
CRDT- 2011/05/26 06:00
PHST- 2011/03/23 00:00 [received]
PHST- 2011/04/16 00:00 [accepted]
PHST- 2011/05/26 06:00 [entrez]
PHST- 2011/05/26 06:00 [pubmed]
PHST- 2012/02/10 06:00 [medline]
AID - 10.1007/s11948-011-9281-3 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2011 Jun;17(2):335-9. doi: 10.1007/s11948-011-9281-3. Epub 2011
      May 26.


PMID- 21611820
OWN - NLM
STAT- MEDLINE
DCOM- 20131126
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 1
DP  - 2013 Mar
TI  - The risks of absolute medical confidentiality.
PG  - 107-22
LID - 10.1007/s11948-011-9283-1 [doi]
AB  - Some ethicists argue that patient confidentiality is absolute and thus should
      never be broken. I examine these arguments that when critically scrutinised,
      become porous. I will explore the concept of patient confidentiality and argue
      that although, this is a very important medical and bioethical issue, this needs 
      to be wisely delivered to reduce third party harm or even detriment to the
      patient. The argument for absolute confidentiality is particularly weak when it
      comes to genetic information and inherited disease.
FAU - Crook, M A
AU  - Crook MA
AD  - Dept. of Clinical Biochemistry and Metabolic Medicine, University Hospital
      Lewisham, Lewisham, UK. martin.crook@doctors.org.uk
LA  - eng
PT  - Journal Article
DEP - 20110525
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Bioethical Issues
MH  - Confidentiality/*ethics
MH  - *Ethics, Medical
MH  - Genetic Diseases, Inborn
MH  - Humans
MH  - Risk
EDAT- 2011/05/26 06:00
MHDA- 2013/12/16 06:00
CRDT- 2011/05/26 06:00
PHST- 2011/01/07 00:00 [received]
PHST- 2011/05/15 00:00 [accepted]
PHST- 2011/05/26 06:00 [entrez]
PHST- 2011/05/26 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1007/s11948-011-9283-1 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Mar;19(1):107-22. doi: 10.1007/s11948-011-9283-1. Epub 2011 
      May 25.


PMID- 21610690
OWN - NLM
STAT- MEDLINE
DCOM- 20111104
LR  - 20211020
IS  - 1759-4766 (Electronic)
IS  - 1759-4758 (Linking)
VI  - 7
IP  - 7
DP  - 2011 May 24
TI  - The ethics of informed consent in Alzheimer disease research.
PG  - 410-4
LID - 10.1038/nrneurol.2011.76 [doi]
AB  - Clinical research on Alzheimer disease (AD) is much needed but requires the
      participation of patients with substantial cognitive impairment who have
      difficulty providing informed consent. Despite decades of debate, policies
      regulating such research are not well-defined. Although numerous studies have
      underscored the difficulties of obtaining informed consent for clinical research 
      from patients compromised by AD, there is also increasing evidence that such
      individuals and their surrogates can make decisions about research participation 
      that are consistent with the patients' values. Policy discussions and future
      research should consider how the ethical reservations about enrolling
      incapacitated patients in research could be mitigated by developing ways to
      promote the congruence between surrogates' decisions and patients' values.
FAU - Kim, Scott Y H
AU  - Kim SY
AD  - Center for Bioethics and Social Sciences in Medicine, University of Michigan, 300
      North Ingalls 7C27, Ann Arbor, Michigan 48109, USA. scottkim@med.umich.edu
LA  - eng
GR  - R01 AG029550/AG/NIA NIH HHS/United States
GR  - R01 MH075023/MH/NIMH NIH HHS/United States
GR  - R01-MH075023/MH/NIMH NIH HHS/United States
GR  - R01-AG029550/AG/NIA NIH HHS/United States
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110524
PL  - England
TA  - Nat Rev Neurol
JT  - Nature reviews. Neurology
JID - 101500072
SB  - IM
MH  - *Alzheimer Disease
MH  - Biomedical Research/*ethics
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Informed Consent/*ethics
PMC - PMC3475518
MID - NIHMS407228
EDAT- 2011/05/26 06:00
MHDA- 2011/11/05 06:00
CRDT- 2011/05/26 06:00
PHST- 2011/05/26 06:00 [entrez]
PHST- 2011/05/26 06:00 [pubmed]
PHST- 2011/11/05 06:00 [medline]
AID - nrneurol.2011.76 [pii]
AID - 10.1038/nrneurol.2011.76 [doi]
PST - epublish
SO  - Nat Rev Neurol. 2011 May 24;7(7):410-4. doi: 10.1038/nrneurol.2011.76.


PMID- 21610508
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20110603
IS  - 1558-2035 (Electronic)
IS  - 1558-2027 (Linking)
VI  - 12
IP  - 7
DP  - 2011 Jul
TI  - Ethical issues on defibrillator deactivation in end-of-life patients.
PG  - 498-500
LID - 10.2459/JCM.0b013e3283483724 [doi]
FAU - Facciorusso, Antonio
AU  - Facciorusso A
FAU - Stanislao, Mario
AU  - Stanislao M
FAU - Fanelli, Mario
AU  - Fanelli M
FAU - Valori, Vanna M
AU  - Valori VM
FAU - Valle, Guido
AU  - Valle G
LA  - eng
PT  - Letter
PL  - United States
TA  - J Cardiovasc Med (Hagerstown)
JT  - Journal of cardiovascular medicine (Hagerstown, Md.)
JID - 101259752
SB  - IM
MH  - Analgesia/ethics
MH  - Defibrillators, Implantable/adverse effects/*ethics
MH  - Electric Countershock/adverse effects/*ethics/instrumentation
MH  - Euthanasia, Active, Voluntary/ethics
MH  - Heart Diseases/*therapy
MH  - Humans
MH  - Italy
MH  - Medical Futility/*ethics
MH  - Personal Autonomy
MH  - Quality of Life
MH  - Right to Die/*ethics
MH  - Stress, Psychological
MH  - Suicide, Assisted/ethics
MH  - Terminal Care/*ethics
MH  - Treatment Refusal/*ethics
EDAT- 2011/05/26 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/05/26 06:00
PHST- 2011/05/26 06:00 [entrez]
PHST- 2011/05/26 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - 10.2459/JCM.0b013e3283483724 [doi]
PST - ppublish
SO  - J Cardiovasc Med (Hagerstown). 2011 Jul;12(7):498-500. doi:
      10.2459/JCM.0b013e3283483724.


PMID- 21609816
OWN - NLM
STAT- MEDLINE
DCOM- 20110816
LR  - 20140325
IS  - 1097-4199 (Electronic)
IS  - 0896-6273 (Linking)
VI  - 70
IP  - 4
DP  - 2011 May 26
TI  - Responsibility rewarded: ethics, engagement, and scientific autonomy in the
      labyrinth of the minotaur.
PG  - 577-81
LID - 10.1016/j.neuron.2011.05.009 [doi]
AB  - Dramatic changes in the stem cell ethical and research ecosystem in the last 10
      years depended on active engagement among scientists, ethicists, government, and 
      public. Tracing that story demonstrates the value of such engagement, and
      forecasts a successful method for meeting future challenges.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Taylor, Patrick L
AU  - Taylor PL
AD  - Petrie-Flom Center for Health Law Policy, Biotechnology, and Bioethics, Harvard
      Law School, Cambridge, MA 02138, USA. patrick.taylor@childrens.harvard.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
SB  - IM
MH  - Animals
MH  - Biomedical Research/economics/*ethics/trends
MH  - Humans
MH  - Neurosciences/economics/*ethics/trends
MH  - *Reward
MH  - *Social Responsibility
MH  - Stem Cell Research/*ethics
EDAT- 2011/05/26 06:00
MHDA- 2011/08/17 06:00
CRDT- 2011/05/26 06:00
PHST- 2011/05/26 06:00 [entrez]
PHST- 2011/05/26 06:00 [pubmed]
PHST- 2011/08/17 06:00 [medline]
AID - S0896-6273(11)00388-6 [pii]
AID - 10.1016/j.neuron.2011.05.009 [doi]
PST - ppublish
SO  - Neuron. 2011 May 26;70(4):577-81. doi: 10.1016/j.neuron.2011.05.009.


PMID- 21609586
OWN - NLM
STAT- MEDLINE
DCOM- 20120105
LR  - 20110525
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 91
IP  - 16
DP  - 2011 Apr 26
TI  - [Chinese guidelines for diagnosis and management of cognitive impairment and
      dementia (VII): care and ethical consultation].
PG  - 1081-3
FAU - Jia, Jian-ping
AU  - Jia JP
FAU - Wang, Yin-hua
AU  - Wang YH
FAU - Cai, Xiao-jie
AU  - Cai XJ
LA  - chi
PT  - Journal Article
PT  - Practice Guideline
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
SB  - IM
MH  - Cognition Disorders/diagnosis/*nursing/therapy
MH  - Dementia/diagnosis/*nursing/therapy
MH  - Humans
MH  - Nursing Care/*ethics
EDAT- 2011/05/26 06:00
MHDA- 2012/01/06 06:00
CRDT- 2011/05/26 06:00
PHST- 2011/05/26 06:00 [entrez]
PHST- 2011/05/26 06:00 [pubmed]
PHST- 2012/01/06 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2011 Apr 26;91(16):1081-3.


PMID- 21609413
OWN - NLM
STAT- MEDLINE
DCOM- 20120202
LR  - 20110928
IS  - 1747-4949 (Electronic)
IS  - 1747-4930 (Linking)
VI  - 6
IP  - 5
DP  - 2011 Oct
TI  - Reading difficulty after stroke: ocular and non ocular causes.
PG  - 404-11
LID - 10.1111/j.1747-4949.2011.00583.x [doi]
AB  - BACKGROUND: Ocular causes of reading impairment following stroke include visual
      field loss, eye movement impairment and poor central vision. Non ocular causes
      may include cognitive errors or language impairment. AIM: The purpose of this
      study was to identify all patients referred with suspected visual impairment who 
      had reported reading difficulty to establish the prevalence of ocular and non
      ocular causes. METHODS: Prospective, multicentre, observation study with
      standardised referral and assessment forms across 21 sites. Visual assessment
      included visual acuity measurement, visual field assessment, ocular alignment,
      and movement and visual inattention assessment. Multicentre ethical approval and 
      informed patient consent were obtained. RESULTS: A total of 915 patients were
      recruited, with a mean age of 69.18 years (standard deviation 14.19). Reading
      difficulties were reported by 177 patients (19.3%), with reading difficulty as
      the only symptom in 39 patients. Fifteen patients had normal visual assessment
      but with a diagnosis of expressive or receptive aphasia. Eight patients had
      alexia. One hundred and nine patients had visual field loss, 85 with eye movement
      abnormality, 27 with low vision and 39 patients with visual perceptual
      impairment. Eighty-seven patients had multiple ocular diagnoses with combined
      visual field, eye movement, low vision or inattention problems. All patients with
      visual impairment were given targeted treatment and/or advice including prisms,
      occlusion, refraction, low vision aids and scanning exercises. CONCLUSIONS:
      Patients complaining of reading difficulty were mostly found to have visual
      impairment relating to low vision, eye movement or visual field loss. A small
      number were found to have non ocular causes of reading difficulty. Treatment or
      advice was possible for all patients with visual impairment.
CI  - (c) 2011 The Authors. International Journal of Stroke (c) 2011 World Stroke
      Organization.
FAU - Rowe, Fiona
AU  - Rowe F
AD  - Orthoptics and vision science, University of Liverpool, Liverpool, UK.
      rowef@liverpool.ac.uk
FAU - Wright, David
AU  - Wright D
FAU - Brand, Darren
AU  - Brand D
FAU - Jackson, Carole
AU  - Jackson C
FAU - Price, Alison
AU  - Price A
FAU - Walker, Linda
AU  - Walker L
FAU - Harrison, Shirley
AU  - Harrison S
FAU - Eccleston, Carla
AU  - Eccleston C
FAU - Maan, Tallat
AU  - Maan T
FAU - Scott, Claire
AU  - Scott C
FAU - Vogwell, Linda
AU  - Vogwell L
FAU - Peel, Sarah
AU  - Peel S
FAU - Robson, Leonie
AU  - Robson L
FAU - Akerman, Nicola
AU  - Akerman N
FAU - Dodridge, Caroline
AU  - Dodridge C
FAU - Howard, Claire
AU  - Howard C
FAU - Shipman, Tracey
AU  - Shipman T
FAU - Sperring, Una
AU  - Sperring U
FAU - Yarde, Sue
AU  - Yarde S
FAU - Rowe, Fiona
AU  - Rowe F
FAU - Macdiarmid, Sonia
AU  - Macdiarmid S
FAU - Freeman, Cicely
AU  - Freeman C
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20110301
PL  - United States
TA  - Int J Stroke
JT  - International journal of stroke : official journal of the International Stroke
      Society
JID - 101274068
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Agnosia/*etiology/physiopathology
MH  - Aphasia/etiology
MH  - Dyslexia, Acquired/*etiology/physiopathology/rehabilitation
MH  - Eyeglasses
MH  - Female
MH  - Hemianopsia/*etiology/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Ocular Motility Disorders/*etiology/physiopathology/rehabilitation
MH  - Orthoptics
MH  - Prospective Studies
MH  - *Reading
MH  - Stroke/*complications/physiopathology
MH  - Visual Acuity
MH  - Visual Fields
MH  - Visual Perception
EDAT- 2011/05/26 06:00
MHDA- 2012/02/03 06:00
CRDT- 2011/05/26 06:00
PHST- 2011/05/26 06:00 [entrez]
PHST- 2011/05/26 06:00 [pubmed]
PHST- 2012/02/03 06:00 [medline]
AID - 10.1111/j.1747-4949.2011.00583.x [doi]
PST - ppublish
SO  - Int J Stroke. 2011 Oct;6(5):404-11. doi: 10.1111/j.1747-4949.2011.00583.x. Epub
      2011 Mar 1.


PMID- 21609172
OWN - NLM
STAT- MEDLINE
DCOM- 20110920
LR  - 20110525
IS  - 1466-187X (Electronic)
IS  - 0142-159X (Linking)
VI  - 33
IP  - 6
DP  - 2011
TI  - The ethics of student assessment.
PG  - 435-6
LID - 10.3109/0142159X.2011.579647 [doi]
FAU - Bandaranayake, Raja C
AU  - Bandaranayake RC
AD  - rajabanda@yahoo.com.au
LA  - eng
PT  - Journal Article
PL  - England
TA  - Med Teach
JT  - Medical teacher
JID - 7909593
SB  - IM
MH  - Clinical Competence
MH  - Decision Making/ethics
MH  - *Educational Measurement
MH  - *Ethics, Professional
MH  - *Faculty, Medical
MH  - Humans
MH  - *Students, Medical
EDAT- 2011/05/26 06:00
MHDA- 2011/09/21 06:00
CRDT- 2011/05/26 06:00
PHST- 2011/05/26 06:00 [entrez]
PHST- 2011/05/26 06:00 [pubmed]
PHST- 2011/09/21 06:00 [medline]
AID - 10.3109/0142159X.2011.579647 [doi]
PST - ppublish
SO  - Med Teach. 2011;33(6):435-6. doi: 10.3109/0142159X.2011.579647.


PMID- 21608506
OWN - NLM
STAT- MEDLINE
DCOM- 20110609
LR  - 20110525
IS  - 1029-4864 (Print)
IS  - 1029-4864 (Linking)
VI  - 66
IP  - 2
DP  - 2011 Mar
TI  - Dental ethics case 9. What to do when the patient cannot pay?
PG  - 89
FAU - Naidoo, S
AU  - Naidoo S
AD  - Department of Community, Oral Health, University of the Western Cape, Private Bag
      X1, Tygerberg, 7505. Tel: 021 937 3148. suenaidoo@uwc.ac.za
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - SADJ
JT  - SADJ : journal of the South African Dental Association = tydskrif van die
      Suid-Afrikaanse Tandheelkundige Vereniging
JID - 9812497
MH  - Emergency Treatment/*ethics
MH  - *Ethics, Dental
MH  - Humans
MH  - Organizational Policy
MH  - Practice Management, Dental/*ethics
MH  - Social Responsibility
MH  - Uncompensated Care/ethics
EDAT- 2011/05/26 06:00
MHDA- 2011/06/10 06:00
CRDT- 2011/05/26 06:00
PHST- 2011/05/26 06:00 [entrez]
PHST- 2011/05/26 06:00 [pubmed]
PHST- 2011/06/10 06:00 [medline]
PST - ppublish
SO  - SADJ. 2011 Mar;66(2):89.


PMID- 21608377
OWN - NLM
STAT- MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 0008-4263 (Print)
IS  - 0008-4263 (Linking)
VI  - 102
IP  - 2
DP  - 2011 Mar-Apr
TI  - Is there a need for heroin substitution treatment in Vancouver's Downtown
      Eastside? Yes there is, and in many other places too.
PG  - 87-9
AB  - The prescription of medically-supervised diacetylmorphine, the active ingredient 
      in heroin, to individuals with treatment-refractory opioid dependence is a
      controversial and often politically charged subject. Just as methadone
      maintenance was opposed in the 1960s by some treatment providers who preferred
      abstinence-based therapies, heroin-assisted therapy is now being opposed by some 
      methadone treatment providers--this despite the fact that the effectiveness of
      heroin-assisted treatment has been demonstrated in no less than six randomized
      trials in Switzerland, the Netherlands, Spain, Germany, Canada and the UK. The
      North American Opiate Medication Initiative (NAOMI) trial in Canada clearly
      showed heroin-assisted therapy to be superior to methadone in individuals with
      chronic, treatment-refractory heroin addiction both in terms of retention in
      addiction treatment and clinical response. An international internal review
      panel, three Research Ethics Boards, the CIHR RCT review panel, the Therapeutic
      Products Directorate of Health Canada, and several journal peer-reviewers
      reviewed the NAOMI trial. Nevertheless, authors of a commentary in this issue of 
      CJPH find fault with the trial in terms of methadone prescribing, use of
      intention-to-treat analysis, safety and cost. We take this opportunity to respond
      to the numerous misconceptions and errors in their commentary.
FAU - Schechter, Martin T
AU  - Schechter MT
AD  - School of Population and Public Health, University of British Columbia, 2206 East
      Mall, Vancouver, BC V6T 1Z3. martin.schechter@ubc.ca
FAU - Kendall, Perry
AU  - Kendall P
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - Switzerland
TA  - Can J Public Health
JT  - Canadian journal of public health = Revue canadienne de sante publique
JID - 0372714
RN  - 0 (Narcotics)
RN  - 70D95007SX (Heroin)
RN  - UC6VBE7V1Z (Methadone)
SB  - IM
CON - Can J Public Health. 2011 Mar-Apr;102(2):84-6. PMID: 21608376
CIN - Can J Public Health. 2011 May-Jun;102(3):235; author reply 235. PMID: 21714326
MH  - Attitude of Health Personnel
MH  - British Columbia
MH  - Heroin/*administration & dosage
MH  - Heroin Dependence/*drug therapy/rehabilitation
MH  - Humans
MH  - Methadone/*administration & dosage
MH  - Narcotics/administration & dosage
MH  - Opiate Substitution Treatment/*methods
MH  - Randomized Controlled Trials as Topic
PMC - PMC6973737
EDAT- 2011/05/26 06:00
MHDA- 2011/07/16 06:00
CRDT- 2011/05/26 06:00
PHST- 2011/05/26 06:00 [entrez]
PHST- 2011/05/26 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
PST - ppublish
SO  - Can J Public Health. 2011 Mar-Apr;102(2):87-9.


PMID- 21608106
OWN - NLM
STAT- MEDLINE
DCOM- 20111012
LR  - 20110621
IS  - 1551-3793 (Electronic)
IS  - 1551-3777 (Linking)
VI  - 7
IP  - 3
DP  - 2011 Jul
TI  - Social and ethical issues in environmental risk management.
PG  - 404-5
LID - 10.1002/ieam.226 [doi]
AB  - The recognition of the social and ethical aspects of radiation risk management
      has been an important part of international projects following the Chernobyl
      accident of 1986. This study comments on the science and policy issues in
      environmental risk assessment, including the social and ethical dimensions of
      emergency preparedness and remediation experiences gained from the Chernobyl
      accident. While the unique situation of Fukushima, combined with an earthquake
      and tsunami, raises its own social and political challenges, it is hoped that
      some of the lessons learnt from Chernobyl will be relevant to long-term
      management of the Fukushima site.
CI  - Copyright (c) 2011 SETAC.
FAU - Oughton, Deborah H
AU  - Oughton DH
AD  - Norwegian University of Life Sciences, 1432 Aas, Norway. deborah.oughton@umb.no
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Integr Environ Assess Manag
JT  - Integrated environmental assessment and management
JID - 101234521
SB  - IM
MH  - *Environment
MH  - Public Policy
MH  - Radioactive Hazard Release
MH  - Risk Management/*ethics
MH  - *Social Change
EDAT- 2011/05/25 06:00
MHDA- 2011/10/13 06:00
CRDT- 2011/05/25 06:00
PHST- 2011/05/25 06:00 [entrez]
PHST- 2011/05/25 06:00 [pubmed]
PHST- 2011/10/13 06:00 [medline]
AID - 10.1002/ieam.226 [doi]
PST - ppublish
SO  - Integr Environ Assess Manag. 2011 Jul;7(3):404-5. doi: 10.1002/ieam.226.


PMID- 21608074
OWN - NLM
STAT- MEDLINE
DCOM- 20121116
LR  - 20151119
IS  - 1099-1611 (Electronic)
IS  - 1057-9249 (Linking)
VI  - 21
IP  - 9
DP  - 2012 Sep
TI  - The impact of molar pregnancy on the male partner.
PG  - 970-6
LID - 10.1002/pon.1992 [doi]
AB  - BACKGROUND: Molar pregnancy is a complication of 1 in 200-2000 pregnancies
      whereby abnormal placental tissue proliferates in the absence of a fetus and may 
      lead to metastases. The disease origin lies in dispermy or dual fertilisation of 
      the egg. The aim of this study was to explore the impact of molar pregnancy upon 
      the male partner. METHODS: Institutional ethics committee approval and individual
      consent were obtained. All women listed on the state molar pregnancy database who
      were receiving active follow-up (n = 102) and a random sample of women who had
      been registered in the previous 30 years (n = 56) were sent a postal survey
      outlining the purpose of the study and an invitation for their partner to
      participate. Sixty-six women gave permission for their partner to participate in 
      the study. Questionnaires included the Hospital Anxiety and Depression Scale,
      Satisfaction with Life Scale and Sexual History Form 12. Responding partners were
      also invited to make comments about any aspect of particular concern. A reminder 
      mail out was issued after 6 weeks. RESULTS: The response rate was 62% (N = 41).
      The key findings were that 32.5% and 12.5% of men met the case criteria for
      anxiety and depressive disorder, respectively. These figures represent a doubling
      of usual community rates for anxiety disorder. However, overall quality of life
      and sexual functioning outcomes were consistent with community samples. The
      presence of children played a protective role and was associated with
      significantly better psychological function and quality of life in univariate and
      multivariate analysis. Qualitative results complemented the quantitative data,
      with anxiety as the dominant emotional theme. CONCLUSION: There are high
      persisting levels of anxiety in male partners of women with molar pregnancy.
      Partners may benefit from therapy where anxiety disorders are detected.
CI  - Copyright (c) 2011 John Wiley & Sons, Ltd.
FAU - Quinlivan, Julie A
AU  - Quinlivan JA
AD  - University of Notre Dame Australia, Fremantle, WA, Australia; Ramsay Healthcare
      Joondalup Health Campus, Joondalup, WA, Australia. quinlivanj@ramsayhealth.com.au
FAU - Ung, Kim A
AU  - Ung KA
FAU - Petersen, Rodney W
AU  - Petersen RW
LA  - eng
PT  - Journal Article
DEP - 20110524
PL  - England
TA  - Psychooncology
JT  - Psycho-oncology
JID - 9214524
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Anxiety/epidemiology/etiology/psychology
MH  - Cross-Sectional Studies
MH  - Depression/epidemiology/etiology/psychology
MH  - Female
MH  - Humans
MH  - Hydatidiform Mole/epidemiology/*psychology
MH  - Male
MH  - Pregnancy
MH  - Pregnancy Complications, Neoplastic/epidemiology/*psychology
MH  - Prevalence
MH  - Psychiatric Status Rating Scales
MH  - Qualitative Research
MH  - Quality of Life
MH  - Sexual Behavior
MH  - Sexual Partners/*psychology
MH  - Social Support
MH  - Socioeconomic Factors
MH  - Spouses/psychology/statistics & numerical data
MH  - Surveys and Questionnaires
MH  - Uterine Neoplasms/epidemiology/*psychology
MH  - Young Adult
EDAT- 2011/05/25 06:00
MHDA- 2012/12/10 06:00
CRDT- 2011/05/25 06:00
PHST- 2010/08/04 00:00 [received]
PHST- 2011/03/30 00:00 [revised]
PHST- 2011/04/04 00:00 [accepted]
PHST- 2011/05/25 06:00 [entrez]
PHST- 2011/05/25 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1002/pon.1992 [doi]
PST - ppublish
SO  - Psychooncology. 2012 Sep;21(9):970-6. doi: 10.1002/pon.1992. Epub 2011 May 24.


PMID- 21607983
OWN - NLM
STAT- MEDLINE
DCOM- 20110912
LR  - 20131121
IS  - 1097-4598 (Electronic)
IS  - 0148-639X (Linking)
VI  - 44
IP  - 2
DP  - 2011 Aug
TI  - Fluoroquinolones influence the intracellular calcium handling in individuals
      susceptible to malignant hyperthermia.
PG  - 208-12
LID - 10.1002/mus.22021 [doi]
AB  - INTRODUCTION: The mechanisms of fluoroquinolone-induced myotoxicity are unknown
      but an involvement of intracellular calcium handling is suspected. An in vitro
      contracture test used to investigate cellular processes in malignant hyperthermia
      (MH) can be applied to study the effects of fluoroquinolones. METHODS: With
      approval of the local ethics committee, muscle biopsies of 18 MH susceptible
      (MHS) and 12 MHS non-susceptible (MHN) pigs were performed. Individual bundles
      were mounted on an isometric force transducer, preloaded, and electrically
      stimulated. After equilibration they were exposed to ciprofloxacin or
      levofloxacin. The measured baseline tension was analyzed (Wilcoxon test: P <
      0.05). RESULTS: There were no differences in weight, length, or predrug tension
      between the groups. Both levofloxacin an ciprofloxacin induced significant
      contractures in MHS muscle bundles but not in MHN. CONCLUSIONS: Fluoroquinolones 
      appear to have a pathological influence on intracellular calcium handling. A
      pre-existing impairment of the calcium homeostasis, however, seems to be
      necessary for this behavior.
CI  - Copyright (c) 2011 Wiley Periodicals, Inc.
FAU - Metterlein, Thomas
AU  - Metterlein T
AD  - Department of Anesthesiology, University Hospital Regensburg,
      Franz-Josef-Strauss-Allee 11, Regensburg 93053, Germany. tom.metterlein@gmx.net
FAU - Schuster, Frank
AU  - Schuster F
FAU - Tadda, Lukas
AU  - Tadda L
FAU - Hager, Martin
AU  - Hager M
FAU - Muldoon, Sheila
AU  - Muldoon S
FAU - Capacchione, John
AU  - Capacchione J
FAU - Roewer, Norbert
AU  - Roewer N
FAU - Anetseder, Martin
AU  - Anetseder M
LA  - eng
PT  - Journal Article
DEP - 20110523
PL  - United States
TA  - Muscle Nerve
JT  - Muscle & nerve
JID - 7803146
RN  - 0 (Fluoroquinolones)
RN  - 0 (Nucleic Acid Synthesis Inhibitors)
RN  - 5E8K9I0O4U (Ciprofloxacin)
RN  - 6GNT3Y5LMF (Levofloxacin)
RN  - A4P49JAZ9H (Ofloxacin)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Calcium/*metabolism
MH  - Ciprofloxacin/pharmacology
MH  - Disease Susceptibility
MH  - Fluoroquinolones/*pharmacology
MH  - Levofloxacin
MH  - Malignant Hyperthermia/genetics/*metabolism
MH  - Muscle Contraction/drug effects
MH  - Muscle, Skeletal/*drug effects/metabolism
MH  - Nucleic Acid Synthesis Inhibitors/*pharmacology
MH  - Ofloxacin/pharmacology
MH  - Swine
EDAT- 2011/05/25 06:00
MHDA- 2011/09/13 06:00
CRDT- 2011/05/25 06:00
PHST- 2011/12/26 00:00 [accepted]
PHST- 2011/05/25 06:00 [entrez]
PHST- 2011/05/25 06:00 [pubmed]
PHST- 2011/09/13 06:00 [medline]
AID - 10.1002/mus.22021 [doi]
PST - ppublish
SO  - Muscle Nerve. 2011 Aug;44(2):208-12. doi: 10.1002/mus.22021. Epub 2011 May 23.


PMID- 21607840
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20211020
IS  - 1867-108X (Electronic)
IS  - 1867-1071 (Linking)
VI  - 29
IP  - 4
DP  - 2011 May
TI  - Pancreatic cancer screening employing noncontrast magnetic resonance imaging
      combined with ultrasonography.
PG  - 265-71
LID - 10.1007/s11604-010-0554-6 [doi]
AB  - PURPOSE: We have conducted an initial evaluation on the potential of combining
      noncontrast magnetic resonance imaging (MRI) and ultrasonography (US) to screen
      for pancreatic cancer. MATERIALS AND METHODS: An independent ethics committee
      approved this study. A total of 2511 patients who underwent US were enrolled.
      Among them, noncontrast MRI was performed in patients in whom the entire pancreas
      was difficult to depict or in those with US-suspected pancreatic lesions. In
      total, using 1.5-T MRI, T1- and T2-weighted imaging, magnetic resonance
      cholangiopancreatography, and diffusion-weighted imaging, we acquired a variety
      of images. The efficacy of US and MRI in screening for pancreatic lesions,
      including pancreatic cancer, was evaluated. RESULTS: Of 2511 patients, 184
      underwent MRI, and the pancreas was demonstrated in all of them. Among the 2511, 
      five pancreatic cancers were detected by MRI combined with US (detection rate
      0.20%). Of the five pancreatic cancers, three were detected by US (detection rate
      0.12%) and two by MRI. Four of the five pancreatic cancers were resectable.
      CONCLUSION: By combining noncontrast MRI with US, pancreatic cancer can be
      detected with high accuracy. Other pancreatic lesions that require follow-up,
      including intraductal papillary mucinous neoplasms, can also be detected. Thus,
      pancreatic cancer screening with a combination of US and MRI is suggested.
FAU - Kuroki-Suzuki, Seiko
AU  - Kuroki-Suzuki S
AD  - Research Center for Cancer Prevention and Screening, National Cancer Center,
      5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. skuroki@ncc.go.jp
FAU - Kuroki, Yoshifumi
AU  - Kuroki Y
FAU - Nasu, Katsuhiro
AU  - Nasu K
FAU - Nagashima, Chieko
AU  - Nagashima C
FAU - Machida, Minoru
AU  - Machida M
FAU - Muramatsu, Yukio
AU  - Muramatsu Y
FAU - Moriyama, Noriyuki
AU  - Moriyama N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110524
PL  - Japan
TA  - Jpn J Radiol
JT  - Japanese journal of radiology
JID - 101490689
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cholangiopancreatography, Magnetic Resonance
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Mass Screening/methods
MH  - Middle Aged
MH  - Pancreatic Neoplasms/*diagnosis/diagnostic imaging
MH  - Prospective Studies
MH  - Ultrasonography
EDAT- 2011/05/25 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/05/25 06:00
PHST- 2010/09/24 00:00 [received]
PHST- 2010/12/16 00:00 [accepted]
PHST- 2011/05/25 06:00 [entrez]
PHST- 2011/05/25 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 10.1007/s11604-010-0554-6 [doi]
PST - ppublish
SO  - Jpn J Radiol. 2011 May;29(4):265-71. doi: 10.1007/s11604-010-0554-6. Epub 2011
      May 24.


PMID- 21607579
OWN - NLM
STAT- MEDLINE
DCOM- 20120315
LR  - 20220408
IS  - 1434-4726 (Electronic)
IS  - 0937-4477 (Linking)
VI  - 268
IP  - 11
DP  - 2011 Nov
TI  - Transnasal endoscopic marsupialization of postoperative maxillary mucoceles:
      middle meatal antrostomy versus inferior meatal antrostomy.
PG  - 1583-7
LID - 10.1007/s00405-011-1636-5 [doi]
AB  - The aim of this study was to evaluate the efficacy of transnasal endoscopic
      marsupialization as a treatment modality in patients with postoperative maxillary
      mucoceles and to compare the efficacy of marsupialization via middle meatal
      antrostomy with that of marsupialization via inferior meatal antrostomy. The
      study design was a retrospective clinical series and the setting was a tertiary
      referral center. After obtaining approval from the local ethics committee, we
      reviewed the medical records of 39 consecutive patients with postoperative
      maxillary mucoceles who were diagnosed and treated at the Department of
      Otolaryngology, Chang Gung Memorial Hospital, Taiwan, from 2004 to 2009.
      Transnasal endoscopic marsupialization was performed on 32 patients (34 sides)
      with postoperative maxillary mucoceles. All patients were followed for more than 
      12 months after surgery, and recurrence was noted in five patients (14.9%).
      Recurrence was experienced by five patients who underwent inferior meatal
      antrostomy and zero patients who underwent middle meatal antrostomy; thus, a
      statistically significant difference (p = 0.04) was observed. Transnasal
      endoscopic marsupialization is an effective modality for postoperative maxillary 
      mucoceles and results in reduced morbidity. The use of middle meatal antrostomy
      in particular is preferred.
FAU - Huang, Chien-Chia
AU  - Huang CC
AD  - Division of Rhinology, Department of Otolaryngology, Chang Gung Memorial Hospital
      and Chang Gung University, Kweishan, Taoyuan, Taiwan.
FAU - Chen, Chiang-Wen
AU  - Chen CW
FAU - Lee, Ta-Jen
AU  - Lee TJ
FAU - Chang, Po-Hung
AU  - Chang PH
FAU - Chen, Yi-Wei
AU  - Chen YW
FAU - Chen, Ying-Lin
AU  - Chen YL
FAU - Fu, Chia-Hsiang
AU  - Fu CH
FAU - Wu, Chia-Chen
AU  - Wu CC
FAU - Huang, Chi-Che
AU  - Huang CC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110524
PL  - Germany
TA  - Eur Arch Otorhinolaryngol
JT  - European archives of oto-rhino-laryngology : official journal of the European
      Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the
      German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JID - 9002937
SB  - IM
MH  - Adult
MH  - Aged
MH  - Endoscopy/*methods
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Maxillary Sinus/diagnostic imaging/pathology/*surgery
MH  - Middle Aged
MH  - Mucocele/diagnosis/*surgery
MH  - Nose
MH  - Otorhinolaryngologic Surgical Procedures/*methods
MH  - Paranasal Sinus Diseases/diagnosis/*surgery
MH  - Retrospective Studies
MH  - Time Factors
MH  - Tomography, X-Ray Computed
MH  - Treatment Outcome
EDAT- 2011/05/25 06:00
MHDA- 2012/03/16 06:00
CRDT- 2011/05/25 06:00
PHST- 2011/03/19 00:00 [received]
PHST- 2011/05/10 00:00 [accepted]
PHST- 2011/05/25 06:00 [entrez]
PHST- 2011/05/25 06:00 [pubmed]
PHST- 2012/03/16 06:00 [medline]
AID - 10.1007/s00405-011-1636-5 [doi]
PST - ppublish
SO  - Eur Arch Otorhinolaryngol. 2011 Nov;268(11):1583-7. doi:
      10.1007/s00405-011-1636-5. Epub 2011 May 24.


PMID- 21607056
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 0975-1505 (Electronic)
IS  - 0975-1483 (Linking)
VI  - 3
IP  - 1
DP  - 2011 Jan
TI  - A study of practical parameters and their relative importance as perceived by
      various stakeholders in clinical trials.
PG  - 60-4
LID - 10.4103/0975-1483.76421 [doi]
AB  - A contract research organization (CRO) is a company which conducts a Good
      Clinical Practice (GCP) in clinical trial. There are literally hundreds of CROs
      worldwide employing a workforce of nearly 100,000 professionals. The project
      proposes the study of practical parameters and their relative importance as
      perceived by the various stakeholders in clinical trials. The survey was
      conducted in Bangalore and New Delhi. Primary market data was obtained by primary
      market research which included 80 clinical trial stakeholders by having a
      preliminary communication with them, followed by administering a questionnaire
      along with prior permission. There were 15 Sponsors/ CROs, 27 Investigators
      /Monitors and 38 Ethics committee members involved in the study. It was shown
      from the study that a clinical investigator involved in a clinical trial is
      responsible for ensuring that an investigation is conducted according to the
      signed investigator statement, the investigational plan, and applicable
      regulations; for protecting the rights, safety, and welfare of the subjects under
      the investigator's care; and for the control of drugs under investigation. It was
      also shown from the study that the sponsors of a clinical trial carry the
      ultimate responsibility for the initiation, management and financing of the
      clinical trial. The study has identified a specific training need at the level of
      the individual stakeholder to perform a particular job function and to identify
      the actual practical parameters in the Indian context important for the
      conduction of clinical trials (GCP) with respect to the different stakeholders,
      to determine the relative importance of these parameters as perceived by various 
      stakeholders involved in clinical trials, and to identify the relative
      contributions of different stakeholders to the success/ satisfactory conduct of a
      clinical trial.
FAU - Pant, R
AU  - Pant R
AD  - Himalayan Institute of Pharmacy & Research, Atak Farm, Rajawala, via Prem Nagar, 
      Dehradun (Uttarakhand), India.
FAU - Joshi, Y
AU  - Joshi Y
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Young Pharm
JT  - Journal of young pharmacists : JYP
JID - 101537066
PMC - PMC3094562
OTO - NOTNLM
OT  - Contract research organizations
OT  - investigators
OT  - sponsors
OT  - stakeholders
EDAT- 2011/05/25 06:00
MHDA- 2011/05/25 06:01
CRDT- 2011/05/25 06:00
PHST- 2011/05/25 06:00 [entrez]
PHST- 2011/05/25 06:00 [pubmed]
PHST- 2011/05/25 06:01 [medline]
AID - 10.4103/0975-1483.76421 [doi]
AID - S0975-1483(11)31010-2 [pii]
PST - ppublish
SO  - J Young Pharm. 2011 Jan;3(1):60-4. doi: 10.4103/0975-1483.76421.


PMID- 21606127
OWN - NLM
STAT- MEDLINE
DCOM- 20120723
LR  - 20151119
IS  - 1477-030X (Electronic)
IS  - 0269-2163 (Linking)
VI  - 26
IP  - 4
DP  - 2012 Jun
TI  - Bereaved relatives' views about participating in cancer research.
PG  - 379-83
LID - 10.1177/0269216311405091 [doi]
AB  - BACKGROUND: Bereaved relatives are considered to be a vulnerable group and there 
      is debate as to whether it is ethical to engage them in research at a time that
      can be difficult for them. AIM: We conducted a cross-sectional study using
      cognitive interviewing with the aim of exploring the acceptability of a mortality
      follow-back survey among bereaved relatives of recently deceased cancer patients 
      to inform the development of a large-scale survey about end-of-life care.
      RESULTS: Thirty-three next-of-kin of recently deceased cancer patients were
      invited to participate in a face-to-face interview, or to complete a postal
      questionnaire. At the end, they were asked about their views of engaging in the
      study. Nine bereaved relatives participated in a face-to-face interview and 11
      completed the postal questionnaire. Eleven relatives reported it was helpful to
      take part in the study; of these, six did not consider it distressing, and five
      stated whilst it had been distressing it had been helpful. Thoughts about
      bringing back memories, altruism and therapeutic value emerged. CONCLUSIONS: We
      have new evidence that although engaging in follow-back surveys can evoke
      distress, many participants report it to be a positive experience. We therefore
      believe that this approach is acceptable when conducted sensitively.
FAU - Koffman, Jonathan
AU  - Koffman J
AD  - King's College London, Cicely Saunders Institute, Department of Palliative Care, 
      Policy and Rehabilitation, London, UK. jonathan.koffman@kcl.ac.uk
FAU - Higginson, Irene J
AU  - Higginson IJ
FAU - Hall, Sue
AU  - Hall S
FAU - Riley, Julia
AU  - Riley J
FAU - McCrone, Paul
AU  - McCrone P
FAU - Gomes, Barbara
AU  - Gomes B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110523
PL  - England
TA  - Palliat Med
JT  - Palliative medicine
JID - 8704926
SB  - IM
CIN - Evid Based Nurs. 2013 Apr;16(2):64-5. PMID: 23144012
MH  - *Bereavement
MH  - Cross-Sectional Studies
MH  - *Ethics, Research
MH  - Family/*psychology
MH  - Female
MH  - Health Services Research/*ethics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/*psychology/therapy
MH  - Research Subjects/*psychology
MH  - Surveys and Questionnaires
MH  - *Terminal Care
EDAT- 2011/05/25 06:00
MHDA- 2012/07/24 06:00
CRDT- 2011/05/25 06:00
PHST- 2011/05/25 06:00 [entrez]
PHST- 2011/05/25 06:00 [pubmed]
PHST- 2012/07/24 06:00 [medline]
AID - 0269216311405091 [pii]
AID - 10.1177/0269216311405091 [doi]
PST - ppublish
SO  - Palliat Med. 2012 Jun;26(4):379-83. doi: 10.1177/0269216311405091. Epub 2011 May 
      23.


PMID- 21606057
OWN - NLM
STAT- MEDLINE
DCOM- 20120525
LR  - 20111123
IS  - 1525-1489 (Electronic)
IS  - 0885-0666 (Linking)
VI  - 26
IP  - 6
DP  - 2011 Nov-Dec
TI  - The history of ethical decision making in neonatal intensive care.
PG  - 368-84
LID - 10.1177/0885066610393315 [doi]
AB  - Neonatal ethics has focused on 2 questions: is withholding potentially
      live-saving treatment from neonates ethically justified? and if so, who has the
      authority to decide? This article details how these questions developed and
      provides a description of the possible answers. In the first section, we review a
      selection of seminal articles by noted authors in the fields of ethics, medicine,
      and law. The second section provides a detailed account of the development of the
      Baby Doe Regulations and the impact they had on neonatal ethics, with particular 
      attention to the emergence of the Best Interest Standard as a guideline for
      decision making. In the last section, we review the landmark position statements 
      by the American Academy of Pediatric (AAP), and the focus on evidence-based
      decision making. We conclude that forgoing life-saving treatment is ethically
      justified. However, this requires a rigorous evidence-based process and is
      limited by the Best Interest Standard. The second question is more difficult to
      answer, but we feel that in light of legal limitations, physicians acting as both
      the infant advocate and a proxy for the state, decide what falls in the range of 
      acceptable treatment options, with the parents free to choose within that range.
FAU - Placencia, Frank X
AU  - Placencia FX
AD  - Department of Pediatrics, Section of Neonatology, Baylor College of Medicine, and
      Texas Children's Hospital, Houston, TX, USA. fxplacen@bcm.edu
FAU - McCullough, Laurence B
AU  - McCullough LB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110523
PL  - United States
TA  - J Intensive Care Med
JT  - Journal of intensive care medicine
JID - 8610344
SB  - IM
MH  - Benchmarking
MH  - Decision Making/*ethics
MH  - Evidence-Based Medicine
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Newborn, Diseases/*therapy
MH  - Intensive Care Units, Neonatal/*ethics/trends
MH  - Life Support Care/*legislation & jurisprudence
MH  - Patient Advocacy
MH  - Pediatrics
MH  - Quality Assurance, Health Care
MH  - *Resuscitation Orders
MH  - Withholding Treatment/legislation & jurisprudence
EDAT- 2011/05/25 06:00
MHDA- 2012/05/26 06:00
CRDT- 2011/05/25 06:00
PHST- 2011/05/25 06:00 [entrez]
PHST- 2011/05/25 06:00 [pubmed]
PHST- 2012/05/26 06:00 [medline]
AID - 0885066610393315 [pii]
AID - 10.1177/0885066610393315 [doi]
PST - ppublish
SO  - J Intensive Care Med. 2011 Nov-Dec;26(6):368-84. doi: 10.1177/0885066610393315.
      Epub 2011 May 23.


PMID- 21605849
OWN - NLM
STAT- MEDLINE
DCOM- 20111122
LR  - 20140211
IS  - 1578-2190 (Electronic)
IS  - 0001-7310 (Linking)
VI  - 102
IP  - 6
DP  - 2011 Jul-Aug
TI  - [Ethics in medical research in humans: a historical perspective].
PG  - 395-401
LID - 10.1016/j.ad.2011.03.016 [doi]
FAU - Sierra, X
AU  - Sierra X
AD  - Dermatologo ICS, Licenciado en Humanidades, CAP Rambla, Terrassa.
LA  - spa
PT  - Historical Article
PT  - Journal Article
TT  - Etica e investigacion medica en humanos: perspectiva historica.
DEP - 20110524
PL  - Spain
TA  - Actas Dermosifiliogr
JT  - Actas dermo-sifiliograficas
JID - 0373062
SB  - IM
MH  - Biomedical Research/*ethics/*history
MH  - History, 18th Century
MH  - History, 19th Century
MH  - History, 20th Century
EDAT- 2011/05/25 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/05/25 06:00
PHST- 2010/10/02 00:00 [received]
PHST- 2011/01/18 00:00 [revised]
PHST- 2011/03/31 00:00 [accepted]
PHST- 2011/05/25 06:00 [entrez]
PHST- 2011/05/25 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0001-7310(11)00194-3 [pii]
AID - 10.1016/j.ad.2011.03.016 [doi]
PST - ppublish
SO  - Actas Dermosifiliogr. 2011 Jul-Aug;102(6):395-401. doi: 10.1016/j.ad.2011.03.016.
      Epub 2011 May 24.


PMID- 21605707
OWN - NLM
STAT- MEDLINE
DCOM- 20111201
LR  - 20211020
IS  - 1872-8278 (Electronic)
IS  - 1567-7249 (Linking)
VI  - 11
IP  - 5
DP  - 2011 Sep
TI  - Why are there no proven therapies for genetic mitochondrial diseases?
PG  - 679-85
LID - 10.1016/j.mito.2011.05.002 [doi]
AB  - Although mitochondrial disease research in general is robust, adequate treatment 
      of these life-threatening conditions has lagged, partly because of a persistence 
      of clinical anecdotes as substitutes for scientifically and ethically rigorous
      clinical trials. Here I summarize the key lessons learned from some of the "first
      generation" of randomized controlled trials for genetic mitochondrial diseases
      and suggest how future trials may benefit from both past experience and exciting 
      new resources available for patient-oriented research and training in this field.
CI  - Copyright (c) 2011 (c) Elsevier B.V. and Mitochondria Research Society. All
      rights reserved. Published by Elsevier B.V. All rights reserved.
FAU - Stacpoole, Peter W
AU  - Stacpoole PW
AD  - Department of Medicine, Division of Endocrinology and Metabolism, College of
      Medicine, University of Florida, Gainesville, FL 32610, USA. pws@ufl.edu
LA  - eng
GR  - R01 FD003032/FD/FDA HHS/United States
GR  - R34 HD065991/HD/NICHD NIH HHS/United States
GR  - R34 HD065991-01/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20110513
PL  - Netherlands
TA  - Mitochondrion
JT  - Mitochondrion
JID - 100968751
RN  - 1339-63-5 (Ubiquinone)
RN  - 9LSH52S3LQ (Dichloroacetic Acid)
RN  - EJ27X76M46 (coenzyme Q10)
SB  - IM
MH  - Acidosis, Lactic/congenital/drug therapy
MH  - Animals
MH  - Dichloroacetic Acid/therapeutic use
MH  - Financing, Government
MH  - Humans
MH  - MELAS Syndrome/drug therapy
MH  - Mitochondrial Diseases/*drug therapy/*genetics
MH  - Neglected Diseases/drug therapy
MH  - Randomized Controlled Trials as Topic/economics/trends
MH  - Rare Diseases/drug therapy
MH  - Societies, Medical/economics/organization & administration
MH  - Ubiquinone/analogs & derivatives/therapeutic use
MH  - United States
PMC - PMC3155622
MID - NIHMS296549
EDAT- 2011/05/25 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/05/25 06:00
PHST- 2011/02/15 00:00 [received]
PHST- 2011/04/04 00:00 [revised]
PHST- 2011/05/05 00:00 [accepted]
PHST- 2011/05/25 06:00 [entrez]
PHST- 2011/05/25 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S1567-7249(11)00190-5 [pii]
AID - 10.1016/j.mito.2011.05.002 [doi]
PST - ppublish
SO  - Mitochondrion. 2011 Sep;11(5):679-85. doi: 10.1016/j.mito.2011.05.002. Epub 2011 
      May 13.


PMID- 21605450
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1471-2253 (Electronic)
IS  - 1471-2253 (Linking)
VI  - 11
DP  - 2011 May 23
TI  - Short term non-invasive ventilation post-surgery improves arterial blood-gases in
      obese subjects compared to supplemental oxygen delivery - a randomized controlled
      trial.
PG  - 10
LID - 10.1186/1471-2253-11-10 [doi]
AB  - BACKGROUND: In the immediate postoperative period, obese patients are more likely
      to exhibit hypoxaemia due to atelectasis and impaired respiratory mechanics,
      changes which can be attenuated by non-invasive ventilation (NIV). The aim of the
      study was to evaluate the duration of any effects of early initiation of short
      term pressure support NIV vs. traditional oxygen delivery via venturi mask in
      obese patients during their stay in the PACU. METHODS: After ethics committee
      approval and informed consent, we prospectively studied 60 obese patients (BMI
      30-45) undergoing minor peripheral surgery. Half were randomly assigned to
      receive short term NIV during their PACU stay, while the others received routine 
      treatment (supplemental oxygen via venturi mask). Premedication, general
      anaesthesia and respiratory settings were standardized. We measured arterial
      oxygen saturation by pulse oximetry and blood gas analysis on air breathing.
      Inspiratory and expiratory lung function was measured preoperatively (baseline)
      and at 10 min, 1 h, 2 h, 6 h and 24 h after extubation, with the patient supine, 
      in a 30 degrees head-up position. The two groups were compared using
      repeated-measure analysis of variance (ANOVA) and t-test analysis. Statistical
      significance was considered to be P < 0.05. RESULTS: There were no differences at
      the first assessment. During the PACU stay, pulmonary function in the NIV group
      was significantly better than in the controls (p < 0.0001). Blood gases and the
      alveolar to arterial oxygen partial pressure difference were also better (p <
      0.03), but with the addition that overall improvements are of questionable
      clinical relevance. These effects persisted for at least 24 hours after surgery
      (p < 0.05). CONCLUSION: Early initiation of short term NIV during in the PACU
      promotes more rapid recovery of postoperative lung function and oxygenation in
      the obese. The effect lasted 24 hours after discontinuation of NIV. Patient
      selection is necessary in order to establish clinically relevant improvements.
      TRIAL REGISTRATION#: DRKS00000751; http://www.germanctr.de.
FAU - Zoremba, Martin
AU  - Zoremba M
AD  - Department of Anaesthesia and Intensive Care Medicine, University of Marburg,
      D-35033 Marburg, Germany. zoremba@med.uni-marburg.de.
FAU - Kalmus, Gerald
AU  - Kalmus G
FAU - Begemann, Domenique
AU  - Begemann D
FAU - Eberhart, Leopold
AU  - Eberhart L
FAU - Zoremba, Norbert
AU  - Zoremba N
FAU - Wulf, Hinnerk
AU  - Wulf H
FAU - Dette, Frank
AU  - Dette F
LA  - eng
PT  - Journal Article
DEP - 20110523
PL  - England
TA  - BMC Anesthesiol
JT  - BMC anesthesiology
JID - 100968535
PMC - PMC3117807
EDAT- 2011/05/25 06:00
MHDA- 2011/05/25 06:01
CRDT- 2011/05/25 06:00
PHST- 2010/09/09 00:00 [received]
PHST- 2011/05/23 00:00 [accepted]
PHST- 2011/05/25 06:00 [entrez]
PHST- 2011/05/25 06:00 [pubmed]
PHST- 2011/05/25 06:01 [medline]
AID - 1471-2253-11-10 [pii]
AID - 10.1186/1471-2253-11-10 [doi]
PST - epublish
SO  - BMC Anesthesiol. 2011 May 23;11:10. doi: 10.1186/1471-2253-11-10.


PMID- 21605359
OWN - NLM
STAT- MEDLINE
DCOM- 20110929
LR  - 20211020
IS  - 1472-6963 (Electronic)
IS  - 1472-6963 (Linking)
VI  - 11
DP  - 2011 May 23
TI  - Missing clinical information in NHS hospital outpatient clinics: prevalence,
      causes and effects on patient care.
PG  - 114
LID - 10.1186/1472-6963-11-114 [doi]
AB  - BACKGROUND: In Britain over 39,000 reports were received by the National Patient 
      Safety Agency relating to failures in documentation in 2007 and the UK Health
      Services Journal estimated in 2008 that over a million hospital outpatient visits
      each year might take place without the full record available. Despite these high 
      numbers, the impact of missing clinical information has not been investigated for
      hospital outpatients in the UK.Studies in primary care in the USA have found
      13.6% of patient consultations have missing clinical information, with this
      adversely affecting care in about half of cases, and in Australia 1.8% of medical
      errors were found to be due to the unavailability of clinical information.Our
      objectives were to assess the frequency, nature and potential impact on patient
      care of missing clinical information in NHS hospital outpatients and to assess
      the principal causes. This is the first study to present such figures for the UK 
      and the first to look at how clinicians respond, including the associated impact 
      on patient care. METHODS: Prospective descriptive study of missing information
      reported by surgeons, supplemented by interviews on the causes.Data were
      collected by surgeons in general, gastrointestinal, colorectal and vascular
      surgical clinics in three teaching hospitals across the UK for over a thousand
      outpatient appointments. Fifteen interviews were conducted with those involved in
      collating clinical information for these clinics.The study had ethics approval
      (Hammersmith and Queen Charlotte's & Chelsea Research Ethics Committee),
      reference number (09/H0707/27). Participants involved in the interviews signed a 
      consent form and were offered the opportunity to review and agree the transcript 
      of their interview before analysis. No patients were involved in this research.
      RESULTS: In 15% of outpatient consultations key items of clinical information
      were missing. Of these patients, 32% experienced a delay or disruption to their
      care and 20% had a risk of harm. In over half of cases the doctor relied on the
      patient for the information, making a clinical decision despite the information
      being missing in 20% of cases. Hospital mergers, temporary staff and
      non-integrated IT systems were contributing factors. CONCLUSIONS: If these
      findings are replicated across the NHS then almost 10 million outpatients are
      seen each year without key clinical information, creating over a million
      unnecessary appointments, and putting nearly 2 million patients at risk of harm. 
      There is a need for a systematic, regular audit of the prevalence of missing
      clinical information. Only then will we know the impact on clinical decision
      making and patient care of new technology, service reorganisations and, crucially
      given the present financial climate, temporary or reduced staffing levels.
      Further research is needed to assess the relationship between missing clinical
      information and diagnostic errors; to examine the issue in primary care; and to
      consider the patients perspective.
FAU - Burnett, Susan J
AU  - Burnett SJ
AD  - Centre for Patient Safety and Service Quality, Imperial College London,
      Department of Surgery, Division of Surgery and Cancer, Faculty of Medicine, St
      Mary's Campus, Norfolk Place, London, UK. s.burnett@imperial.ac.uk
FAU - Deelchand, Vashist
AU  - Deelchand V
FAU - Franklin, Bryony Dean
AU  - Franklin BD
FAU - Moorthy, Krishna
AU  - Moorthy K
FAU - Vincent, Charles
AU  - Vincent C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110523
PL  - England
TA  - BMC Health Serv Res
JT  - BMC health services research
JID - 101088677
SB  - IM
MH  - Confidence Intervals
MH  - *Health Records, Personal
MH  - Hospitals, Teaching
MH  - Humans
MH  - Outpatient Clinics, Hospital/*statistics & numerical data
MH  - Outpatients/*statistics & numerical data
MH  - Patient Care/*methods/statistics & numerical data
MH  - Prevalence
MH  - Prospective Studies
MH  - Referral and Consultation/*statistics & numerical data
MH  - Risk Factors
MH  - State Medicine
MH  - Systems Analysis
MH  - United Kingdom
PMC - PMC3118108
EDAT- 2011/05/25 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/05/25 06:00
PHST- 2010/10/08 00:00 [received]
PHST- 2011/05/23 00:00 [accepted]
PHST- 2011/05/25 06:00 [entrez]
PHST- 2011/05/25 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - 1472-6963-11-114 [pii]
AID - 10.1186/1472-6963-11-114 [doi]
PST - epublish
SO  - BMC Health Serv Res. 2011 May 23;11:114. doi: 10.1186/1472-6963-11-114.


PMID- 21605154
OWN - NLM
STAT- MEDLINE
DCOM- 20120719
LR  - 20220409
IS  - 1471-6712 (Electronic)
IS  - 0283-9318 (Linking)
VI  - 26
IP  - 1
DP  - 2012 Mar
TI  - Living with haemodialysis when nearing end of life.
PG  - 45-52
LID - 10.1111/j.1471-6712.2011.00902.x [doi]
AB  - AIMS AND OBJECTIVES: The aim of this study was to describe and to elucidate the
      meanings of being severely ill living with haemodialysis when nearing end of
      life. INTRODUCTION: To have end stage renal disease and to be treated with
      maintenance haemodialysis implies being dependent on lifelong treatment. Several 
      studies have reported that these patients suffer a high symptom burden and an
      impaired quality of life due to both disease and treatment. In the dialysis unit,
      where the focus is on handling technology and maintaining life, end of life care 
      may be neglected or overlooked. Nevertheless, mortality rates show that about
      one-fourth of patients in haemodialysis care are in their last year of life.
      DESIGN: A qualitative interpretative design was used. METHODS: Serial qualitative
      interviews over a period of 12 months were conducted with eight patients (aged
      66-87). Altogether text of 31 interviews was interpreted using a phenomenological
      hermeneutical method in three phases. The study is ethically approved. FINDINGS: 
      The structural analysis resulted in 11 subthemes and thereafter the following
      three themes were formulated; being subordinate to the deteriorating body,
      changing outlook on life and striving for upheld dignity. The comprehensive
      interpretation revealed that being severely ill living with haemodialysis near
      the end of life means living with suffering simultaneously with reconciliation
      and well-being. Further, the meanings are understood as intertwined with being
      old. CONCLUSIONS: Findings contribute to an increased awareness of the
      complexities of these patients' life worlds and their meanings, and thus of the
      importance to listen to their experiences and their understandings. Findings
      suggest that to integrate the philosophy of palliative care in haemodialysis
      units may improve care for patients who are living with haemodialysis and
      approaching the end of their lives.
CI  - (c) 2011 The Authors. Scandinavian Journal of Caring Sciences (c) 2011 Nordic
      College of Caring Science.
FAU - Axelsson, Lena
AU  - Axelsson L
AD  - Sophiahemmet University College, Stockholm, Sweden. lena.axelsson@shh.se
FAU - Randers, Ingrid
AU  - Randers I
FAU - Jacobson, Stefan H
AU  - Jacobson SH
FAU - Klang, Birgitta
AU  - Klang B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110524
PL  - Sweden
TA  - Scand J Caring Sci
JT  - Scandinavian journal of caring sciences
JID - 8804206
MH  - *Adaptation, Psychological
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - Kidney Failure, Chronic/*psychology/therapy
MH  - Male
MH  - Qualitative Research
MH  - *Quality of Life
MH  - Renal Dialysis/*psychology
MH  - Sweden
MH  - Terminally Ill/*psychology
EDAT- 2011/05/25 06:00
MHDA- 2012/07/20 06:00
CRDT- 2011/05/25 06:00
PHST- 2011/05/25 06:00 [entrez]
PHST- 2011/05/25 06:00 [pubmed]
PHST- 2012/07/20 06:00 [medline]
AID - 10.1111/j.1471-6712.2011.00902.x [doi]
PST - ppublish
SO  - Scand J Caring Sci. 2012 Mar;26(1):45-52. doi: 10.1111/j.1471-6712.2011.00902.x. 
      Epub 2011 May 24.


PMID- 21604282
OWN - NLM
STAT- MEDLINE
DCOM- 20110824
LR  - 20191210
IS  - 1531-4995 (Electronic)
IS  - 0023-852X (Linking)
VI  - 121
IP  - 6
DP  - 2011 Jun
TI  - The ethics of medical publication.
PG  - 1132
LID - 10.1002/lary.21878 [doi]
FAU - Johnson, Jonas T
AU  - Johnson JT
LA  - eng
PT  - Editorial
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
SB  - IM
MH  - Duplicate Publications as Topic
MH  - Humans
MH  - Periodicals as Topic/ethics/*standards
MH  - *Scientific Misconduct/ethics
EDAT- 2011/05/24 06:00
MHDA- 2011/08/25 06:00
CRDT- 2011/05/24 06:00
PHST- 2011/05/24 06:00 [entrez]
PHST- 2011/05/24 06:00 [pubmed]
PHST- 2011/08/25 06:00 [medline]
AID - 10.1002/lary.21878 [doi]
PST - ppublish
SO  - Laryngoscope. 2011 Jun;121(6):1132. doi: 10.1002/lary.21878.


PMID- 21604188
OWN - NLM
STAT- MEDLINE
DCOM- 20120223
LR  - 20130424
IS  - 1573-6768 (Electronic)
IS  - 1389-5729 (Linking)
VI  - 12
IP  - 6
DP  - 2011 Dec
TI  - Ethical aspects of aging research.
PG  - 491-502
LID - 10.1007/s10522-011-9340-9 [doi]
AB  - During the last 50-60 years, due to development of medical care and hygienically 
      safe living conditions, the average life span of European citizens has
      substantially increased, with a rapid growth of the population older than 65
      years. This trend places ever-growing medical and economical burden on society,
      as many of the older subjects suffer from age-related diseases and frailty.
      Coping with these problems requires not only appropriate medical treatment and
      social support but also extensive research in many fields of aging-from biology
      to sociology, with involvement of older people as the research subjects. This
      work anticipates development and application of ethical standards suited to
      dynamic advances in aging research. The aim of this review is to update the
      knowledge in ethical requirements toward recruitment of older research subjects, 
      obtaining of informed consent, collection of biological samples, and use of stem 
      cells in preclinical and clinical settings. It is concluded that application of
      adequate ethical platform markedly facilitates recruitment of older persons for
      participation in research. Currently, the basic ethical concepts are subjected to
      extensive discussion, with participation of all interested parties, in order to
      guarantee successful research on problems of human aging, protect older people
      from undesired interference, and afford their benefits through supporting
      innovations in research, therapy, and care.
FAU - Seppet, Enn
AU  - Seppet E
AD  - Department of Pathophysiology, Institute of General and Molecular Pathology,
      University of Tartu, Estonia. enn.seppet@ut.ee
FAU - Paasuke, Mati
AU  - Paasuke M
FAU - Conte, Maria
AU  - Conte M
FAU - Capri, Miriam
AU  - Capri M
FAU - Franceschi, Claudio
AU  - Franceschi C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110522
PL  - Netherlands
TA  - Biogerontology
JT  - Biogerontology
JID - 100930043
SB  - IM
MH  - Aged
MH  - *Aging
MH  - Animals
MH  - Biomedical Research/*ethics
MH  - Geriatrics/*ethics
MH  - Guidelines as Topic
MH  - Humans
MH  - *Informed Consent
MH  - Longevity
MH  - Patient Selection/ethics
MH  - Specimen Handling/ethics
MH  - Stem Cell Research/ethics
MH  - Tissue Banks/ethics
EDAT- 2011/05/24 06:00
MHDA- 2012/02/24 06:00
CRDT- 2011/05/24 06:00
PHST- 2010/12/13 00:00 [received]
PHST- 2011/05/10 00:00 [accepted]
PHST- 2011/05/24 06:00 [entrez]
PHST- 2011/05/24 06:00 [pubmed]
PHST- 2012/02/24 06:00 [medline]
AID - 10.1007/s10522-011-9340-9 [doi]
PST - ppublish
SO  - Biogerontology. 2011 Dec;12(6):491-502. doi: 10.1007/s10522-011-9340-9. Epub 2011
      May 22.


PMID- 21604023
OWN - NLM
STAT- MEDLINE
DCOM- 20111212
LR  - 20211020
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 23
IP  - 2
DP  - 2011 Jun
TI  - Ethical review of global short-term medical volunteerism.
PG  - 91-103
LID - 10.1007/s10730-011-9152-y [doi]
AB  - Global short-term medical volunteerism is growing, and properly conducted, is a
      tool in the fight for greater global health equity. It is intrinsically "ethical"
      (i.e., it involves ethics at every step) and depends upon ethical conduct for its
      success. At present, ethical guidelines remain in their infancy, which presents a
      unique opportunity. This paper presents a set of basic ethical principles,
      building on prior work in this area and previously developed guidelines for
      international clinical research. The content of these principles, and the
      benchmarks used to evaluate them, remain intentionally vague and can only be
      filled by collaboration with those on-the-ground in local communities where this 
      work occurs. Ethical review must additionally take into consideration the
      different obligations arising from the type of institution, type of intervention,
      and type of relationship involved. This paper argues that frequent and formalized
      ethical review, conducted from the beginning with the local community (where this
      community helps define the terms of debate), remains the most important ethical
      safeguard for this work.
FAU - DeCamp, Matthew
AU  - DeCamp M
AD  - Division of General Internal Medicine, Johns Hopkins Berman Institute of
      Bioethics, 1830 E Monument Street, Room 8011, Baltimore, MD 21287, USA.
      mdecamp1@jhmi.edu
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - *Developing Countries
MH  - Global Health
MH  - Humans
MH  - Medical Missions/*ethics
MH  - *Volunteers
EDAT- 2011/05/24 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/05/24 06:00
PHST- 2011/05/24 06:00 [entrez]
PHST- 2011/05/24 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 10.1007/s10730-011-9152-y [doi]
PST - ppublish
SO  - HEC Forum. 2011 Jun;23(2):91-103. doi: 10.1007/s10730-011-9152-y.


PMID- 21604022
OWN - NLM
STAT- MEDLINE
DCOM- 20111212
LR  - 20220408
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 23
IP  - 2
DP  - 2011 Jun
TI  - The context of ethical problems in medical volunteer work.
PG  - 79-90
LID - 10.1007/s10730-011-9155-8 [doi]
AB  - Ethical problems are common in clinical medicine, so medical volunteers who
      practice clinical medicine in developing countries should expect to encounter
      them just as they would in their practice in the developed world. However, as
      this article argues, medical volunteers in developing countries should not expect
      to encounter the same ethical problems as those that dominate Western biomedicine
      or to address ethical problems in the same way as they do in their practice in
      developed countries. For example, poor health and advanced disease increase the
      risks and decrease the potential benefits of some interventions. Consequently,
      when medical volunteers intervene too readily, without considering the
      nutritional and general health status of patients, the results can be
      devastating. Medical volunteers cannot assume that the outcomes of interventions 
      in developing countries will be comparable to the outcomes of the same
      interventions in developed countries. Rather, they must realistically consider
      the complex medical conditions of patients when determining whether or not to
      intervene. Similarly, medical volunteers may face the question of whether to
      provide a pharmaceutical or perform an intervention that is below the acceptable 
      standard of care versus the alternative of doing nothing. This article critically
      explores the contextual features of medical volunteer work in developing
      countries that differentiate it from medical practice in developed countries,
      arguing that this context contributes to the creation of unique ethical problems 
      and affects the way in which these problems should be analyzed and resolved.
FAU - Wall, Anji
AU  - Wall A
AD  - Saint Louis University School of Medicine, 1402 South Grand Ave., St. Louis, MO
      63104, USA. wallae@slu.edu
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - Developing Countries
MH  - Humans
MH  - Medical Missions/*ethics
MH  - *Volunteers
EDAT- 2011/05/24 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/05/24 06:00
PHST- 2011/05/24 06:00 [entrez]
PHST- 2011/05/24 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 10.1007/s10730-011-9155-8 [doi]
PST - ppublish
SO  - HEC Forum. 2011 Jun;23(2):79-90. doi: 10.1007/s10730-011-9155-8.


PMID- 21603043
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 1871-4757 (Print)
IS  - 1871-4757 (Linking)
VI  - 5
IP  - 1
DP  - 2011 Apr
TI  - Precaution or Integrated Responsibility Approach to Nanovaccines in Fish Farming?
      A Critical Appraisal of the UNESCO Precautionary Principle.
PG  - 73-86
AB  - Nanoparticles have multifaceted advantages in drug administration as vaccine
      delivery and hence hold promises for improving protection of farmed fish against 
      diseases caused by pathogens. However, there are concerns that the benefits
      associated with distribution of nanoparticles may also be accompanied with risks 
      to the environment and health. The complexity of the natural and social systems
      involved implies that the information acquired in quantified risk assessments may
      be inadequate for evidence-based decisions. One controversial strategy for
      dealing with this kind of uncertainty is the precautionary principle. A few years
      ago, an UNESCO expert group suggested a new approach for implementation of the
      principle. Here we compare the UNESCO principle with earlier versions and explore
      the advantages and disadvantages by employing the UNESCO version to the use of
      PLGA nanoparticles for delivery of vaccines in aquaculture. Finally, we discuss
      whether a combined scientific and ethical analysis that involves the concept of
      responsibility will enable approaches that can provide a supplement to the
      precautionary principle as basis for decision-making in areas of scientific
      uncertainty, such as the application of nanoparticles in the vaccination of
      farmed fish.
FAU - Myhr, Anne Ingeborg
AU  - Myhr AI
FAU - Myskja, Bjorn K
AU  - Myskja BK
LA  - eng
PT  - Journal Article
DEP - 20110405
PL  - Netherlands
TA  - Nanoethics
JT  - Nanoethics
JID - 101311055
PMC - PMC3074079
EDAT- 2011/05/24 06:00
MHDA- 2011/05/24 06:01
CRDT- 2011/05/24 06:00
PHST- 2010/12/14 00:00 [received]
PHST- 2011/03/06 00:00 [accepted]
PHST- 2011/05/24 06:00 [entrez]
PHST- 2011/05/24 06:00 [pubmed]
PHST- 2011/05/24 06:01 [medline]
AID - 10.1007/s11569-011-0112-4 [doi]
AID - 112 [pii]
PST - ppublish
SO  - Nanoethics. 2011 Apr;5(1):73-86. doi: 10.1007/s11569-011-0112-4. Epub 2011 Apr 5.


PMID- 21602440
OWN - NLM
STAT- MEDLINE
DCOM- 20110920
LR  - 20220408
IS  - 1545-7230 (Electronic)
IS  - 1042-9670 (Linking)
VI  - 35
IP  - 3
DP  - 2011 May-Jun
TI  - Psychiatric residents' needs for education about informed consent, principles of 
      ethics and professionalism, and caring for vulnerable populations: results of a
      multisite survey.
PG  - 184-90
LID - 10.1176/appi.ap.35.3.184 [doi]
AB  - OBJECTIVE: The authors examined psychiatric residents' perceived needs for
      education in informed consent, principles of ethics and professionalism, and
      treating vulnerable populations. METHOD: A written survey was distributed to
      psychiatric residents (N=249) at seven U.S. residency programs in 2005. The
      survey contained 149 questions in 10 content domains, 6 questions regarding
      personal ethics experiences during training, and 5 demographic questions. Here,
      the authors report responses to items regarding informed consent, professional
      principles, and care of vulnerable populations. RESULTS: A total of 151
      psychiatric residents responded to the survey (61% overall response rate). On a
      scale of 1: Much Less, to 5: Same, to 9: Much More Education Desired, psychiatric
      residents indicated that 9 topics relating to informed consent, 10 issues
      surrounding professional principles, and 25 topics relating to care of vulnerable
      populations should receive more educational attention than currently provided. No
      topics were rated as needing less education. Higher ratings of the need for
      additional educational attention were associated with more reported ethical
      conflicts encountered during training. CONCLUSION: Psychiatric residents at seven
      diverse U.S. training programs expressed the need for greater educational
      attention to issues around informed consent, ethical and professional principles,
      and treating vulnerable populations. These findings reflect the ongoing need for 
      educators to devote curricular attention to these areas so that trainees can
      incorporate such knowledge effectively into their daily clinical practice in an
      always-complex, highly fragmented medical care environment.
FAU - Jain, Shaili
AU  - Jain S
AD  - VA Palo Alto Health Care System NCPTSD, Menlo Park, CA 94205, USA.
      sjain1@stanford.edu
FAU - Lapid, Maria I
AU  - Lapid MI
FAU - Dunn, Laura B
AU  - Dunn LB
FAU - Roberts, Laura Weiss
AU  - Roberts LW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Acad Psychiatry
JT  - Academic psychiatry : the journal of the American Association of Directors of
      Psychiatric Residency Training and the Association for Academic Psychiatry
JID - 8917200
SB  - IM
MH  - Curriculum
MH  - Data Collection
MH  - Ethics, Medical/*education
MH  - Humans
MH  - *Informed Consent/ethics
MH  - *Internship and Residency
MH  - Needs Assessment
MH  - Psychiatry/*education/ethics/standards
MH  - United States
MH  - *Vulnerable Populations
EDAT- 2011/05/24 06:00
MHDA- 2011/09/21 06:00
CRDT- 2011/05/24 06:00
PHST- 2011/05/24 06:00 [entrez]
PHST- 2011/05/24 06:00 [pubmed]
PHST- 2011/09/21 06:00 [medline]
AID - 35/3/184 [pii]
AID - 10.1176/appi.ap.35.3.184 [doi]
PST - ppublish
SO  - Acad Psychiatry. 2011 May-Jun;35(3):184-90. doi: 10.1176/appi.ap.35.3.184.


PMID- 21602439
OWN - NLM
STAT- MEDLINE
DCOM- 20110920
LR  - 20220408
IS  - 1545-7230 (Electronic)
IS  - 1042-9670 (Linking)
VI  - 35
IP  - 3
DP  - 2011 May-Jun
TI  - Results of a multisite survey of U.S. psychiatry residents on education in
      professionalism and ethics.
PG  - 175-83
LID - 10.1176/appi.ap.35.3.175 [doi]
AB  - OBJECTIVE: The authors assess the perspectives of psychiatry residents about the 
      goals of receiving education in professionalism and ethics, how topics should be 
      taught, and on what ethical principles the curriculum should be based. METHOD: A 
      written survey was sent to psychiatry residents (N=249) at seven U.S. residency
      programs in Spring 2005. The survey was based on an instrument originally
      developed at the University of New Mexico, consisting of 149 questions in 10
      content domains, with 6 questions regarding ethics experiences during training
      and 5 demographic questions. RESULTS: A total of 151 psychiatry residents (61%)
      returned usable responses to our survey. Residents reported receiving a moderate 
      amount of ethics training during medical school (mean: 5.20; scale: 1: None to 9:
      Very Much) and some ethics training during residency (mean: 4.60). Residents
      endorsed moderate to moderately-strong agreement with all 11 goals of medical
      education in professionalism and ethics (means: 5.29 to 7.49; scale: 1: Strongly 
      Disagree to 9: Strongly Agree). Respondents were more likely to endorse the value
      of clinically- and expert-oriented learning methods over web-based educational
      approaches. CONCLUSION: U.S. psychiatry residents endorse a range of goals for
      education in professionalism and ethics. At the same time, they prefer that these
      topics be taught in clinically relevant ways and through expert instruction. The 
      value of web-based approaches warrants further investigation.
FAU - Jain, Shaili
AU  - Jain S
AD  - VA Palo Alto Health Care System NCPTSD, Menlo Park, CA 94205, USA.
      sjain1@stanford.edu
FAU - Dunn, Laura B
AU  - Dunn LB
FAU - Warner, Christopher H
AU  - Warner CH
FAU - Roberts, Laura Weiss
AU  - Roberts LW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Acad Psychiatry
JT  - Academic psychiatry : the journal of the American Association of Directors of
      Psychiatric Residency Training and the Association for Academic Psychiatry
JID - 8917200
SB  - IM
MH  - Adult
MH  - Curriculum/standards
MH  - Data Collection
MH  - Female
MH  - Goals
MH  - Humans
MH  - *Internship and Residency
MH  - Male
MH  - Psychiatry/*education/ethics/standards
MH  - Schools, Medical/standards
MH  - United States
EDAT- 2011/05/24 06:00
MHDA- 2011/09/21 06:00
CRDT- 2011/05/24 06:00
PHST- 2011/05/24 06:00 [entrez]
PHST- 2011/05/24 06:00 [pubmed]
PHST- 2011/09/21 06:00 [medline]
AID - 35/3/175 [pii]
AID - 10.1176/appi.ap.35.3.175 [doi]
PST - ppublish
SO  - Acad Psychiatry. 2011 May-Jun;35(3):175-83. doi: 10.1176/appi.ap.35.3.175.


PMID- 21602438
OWN - NLM
STAT- MEDLINE
DCOM- 20110920
LR  - 20110523
IS  - 1545-7230 (Electronic)
IS  - 1042-9670 (Linking)
VI  - 35
IP  - 3
DP  - 2011 May-Jun
TI  - Professional boundaries in the era of the Internet.
PG  - 168-74
LID - 10.1176/appi.ap.35.3.168 [doi]
AB  - OBJECTIVE: The era of the Internet presents new dilemmas in educating
      psychiatrists about professional boundaries. The objective of this overview is to
      clarify those dilemmas and offer recommendations for dealing with them. METHOD:
      The characteristics of social networking sites, blogs, and search engines are
      reviewed with a specific focus on their potential to present problems of
      professional boundaries for psychiatrists. RESULTS: The professional boundary
      questions that have arisen in the expanded world of online communication can be
      subdivided into three areas: ethical concerns, professionalism issues, and
      clinical dilemmas. Only the first category involves true boundary problems as
      normally defined. CONCLUSIONS: The expansion of the Internet has redefined
      traditional areas of privacy and anonymity in the clinical setting. Guidelines
      are proposed to manage the alteration of professional boundaries, as well as
      issues of professionalism and clinical work, that have arisen from the
      complexities of cyberspace. The author discusses implications for residency
      training.
FAU - Gabbard, Glen O
AU  - Gabbard GO
AD  - Department of Psychiatry, Baylor College of Medicine, Houston, TX 77401, USA.
      ggabbard12@aol.com
FAU - Kassaw, Kristin A
AU  - Kassaw KA
FAU - Perez-Garcia, Gonzalo
AU  - Perez-Garcia G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Acad Psychiatry
JT  - Academic psychiatry : the journal of the American Association of Directors of
      Psychiatric Residency Training and the Association for Academic Psychiatry
JID - 8917200
SB  - IM
MH  - Blogging/standards
MH  - Communication
MH  - Humans
MH  - *Internet/standards
MH  - Physician's Role
MH  - Physician-Patient Relations/ethics
MH  - Privacy
MH  - Psychiatry/education/ethics/*standards
MH  - Social Support
EDAT- 2011/05/24 06:00
MHDA- 2011/09/21 06:00
CRDT- 2011/05/24 06:00
PHST- 2011/05/24 06:00 [entrez]
PHST- 2011/05/24 06:00 [pubmed]
PHST- 2011/09/21 06:00 [medline]
AID - 35/3/168 [pii]
AID - 10.1176/appi.ap.35.3.168 [doi]
PST - ppublish
SO  - Acad Psychiatry. 2011 May-Jun;35(3):168-74. doi: 10.1176/appi.ap.35.3.168.


PMID- 21601880
OWN - NLM
STAT- MEDLINE
DCOM- 20120106
LR  - 20111114
IS  - 1095-8673 (Electronic)
IS  - 0022-4804 (Linking)
VI  - 171
IP  - 2
DP  - 2011 Dec
TI  - Assessing residents in surgical ethics: we do it a lot; we only know a little.
PG  - 395-8
LID - 10.1016/j.jss.2011.04.008 [doi]
AB  - BACKGROUND: PGY-1 year of surgical residency brings together many persons of
      disparate experiences and educational backgrounds, including their exposure to
      ethics. We hypothesized that surgical PGY-1s would have a similar exposure to
      ethical scenarios but lack the confidence in practice and understanding of
      ethical principles compared with more senior residents. MATERIALS AND METHODS:
      Surgical residents were invited to resident-initiated surgical ethics workshops
      utilizing a standardized text. Here a survey and multiple choice tests were
      administered to participants. The survey determined prior exposure to ethics
      curricula, the frequency of exposure to various ethics topics, and their comfort 
      with these scenarios. A multiple choice test then quantified the knowledge base
      of participating residents. The results were collected and compared between
      surgical PGY-1s and more senior residents. RESULTS: Eighteen PGY-1s and 12 senior
      residents completed this curriculum. Resident exposure to ethical concepts was
      common. Resident confidence in these topics was ranked moderate or higher for
      both groups. Despite frequent clinical exposure and strong confidence in their
      skills of addressing these topics, performance on the test was poor, with an
      average score of 59% for PGY-1s and 47% for more senior residents (P=0.03).
      CONCLUSIONS: Despite clinical exposure to and confidence in their management of
      ethical topics, their knowledge base was poor and worse for more senior
      residents. Given the overall interest in a formal ethics curriculum and the
      knowledge deficit demonstrated, educational intervention and professional ethics 
      support should be provided for surgical residents even with the current
      educational time constraints.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Brewster, Luke P
AU  - Brewster LP
AD  - Department of Surgery, Emory University Hospital, Atlanta, Georgia 30022, USA.
      lukebrewst@aol.com
FAU - Hall, Dan E
AU  - Hall DE
FAU - Joehl, Raymond J
AU  - Joehl RJ
LA  - eng
PT  - Journal Article
DEP - 20110504
PL  - United States
TA  - J Surg Res
JT  - The Journal of surgical research
JID - 0376340
SB  - IM
MH  - Adult
MH  - Curriculum
MH  - Education, Medical, Undergraduate/*methods
MH  - Ethics, Medical/*education
MH  - Female
MH  - General Surgery/*education/*ethics
MH  - Health Care Surveys
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Internship and Residency/*ethics
MH  - Male
EDAT- 2011/05/24 06:00
MHDA- 2012/01/10 06:00
CRDT- 2011/05/24 06:00
PHST- 2011/01/08 00:00 [received]
PHST- 2011/03/24 00:00 [revised]
PHST- 2011/04/05 00:00 [accepted]
PHST- 2011/05/24 06:00 [entrez]
PHST- 2011/05/24 06:00 [pubmed]
PHST- 2012/01/10 06:00 [medline]
AID - S0022-4804(11)00361-1 [pii]
AID - 10.1016/j.jss.2011.04.008 [doi]
PST - ppublish
SO  - J Surg Res. 2011 Dec;171(2):395-8. doi: 10.1016/j.jss.2011.04.008. Epub 2011 May 
      4.


PMID- 21601753
OWN - NLM
STAT- MEDLINE
DCOM- 20120229
LR  - 20201209
IS  - 1878-1306 (Electronic)
IS  - 0195-5616 (Linking)
VI  - 41
IP  - 3
DP  - 2011 May
TI  - Euthanasia, moral stress, and chronic illness in veterinary medicine.
PG  - 651-9
LID - 10.1016/j.cvsm.2011.03.005 [doi]
AB  - Euthanasia is a double-edged sword in veterinary medicine. It is a powerful and
      ultimately the most powerful tool for ending the pain and suffering. Demand for
      its use for client convenience is morally reprehensible and creates major moral
      stress for ethically conscious practitioners. But equally reprehensible and
      stressful to veterinarians is the failure to use it when an animal faces only
      misery, pain, distress, and suffering. Finding the correct path through this
      minefield may well be the most important ethical task facing the conscientious
      veterinarian.
CI  - 2011 Elsevier Inc. All rights reserved.
FAU - Rollin, Bernard E
AU  - Rollin BE
AD  - Department of Philosophy, Colorado State University, 240 Eddy Hall, Fort Collins,
      CO 80523-1781, USA. Bernard.Rollin@colostate.edu
LA  - eng
PT  - Journal Article
DEP - 20110420
PL  - United States
TA  - Vet Clin North Am Small Anim Pract
JT  - The Veterinary clinics of North America. Small animal practice
JID - 7809942
SB  - IM
MH  - Animals
MH  - Chronic Disease
MH  - *Decision Making
MH  - Ethics, Medical
MH  - *Euthanasia, Animal
MH  - Hospice Care
MH  - *Human-Animal Bond
MH  - Humans
MH  - Morals
MH  - Palliative Care
MH  - Pets/psychology
MH  - *Professional-Patient Relations
MH  - Quality of Life
MH  - *Stress, Psychological
MH  - Veterinarians/*psychology
MH  - Veterinary Medicine/methods
EDAT- 2011/05/24 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/05/24 06:00
PHST- 2011/05/24 06:00 [entrez]
PHST- 2011/05/24 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - S0195-5616(11)00030-1 [pii]
AID - 10.1016/j.cvsm.2011.03.005 [doi]
PST - ppublish
SO  - Vet Clin North Am Small Anim Pract. 2011 May;41(3):651-9. doi:
      10.1016/j.cvsm.2011.03.005. Epub 2011 Apr 20.


PMID- 21601752
OWN - NLM
STAT- MEDLINE
DCOM- 20120229
LR  - 20110523
IS  - 1878-1306 (Electronic)
IS  - 0195-5616 (Linking)
VI  - 41
IP  - 3
DP  - 2011 May
TI  - Ten tips for veterinarians dealing with terminally ill patients.
PG  - 647-9
LID - 10.1016/j.cvsm.2011.03.012 [doi]
AB  - This article discusses tips for veterinarians dealing with terminally ill
      patients. These tips include veterinarians taking care of themselves physically, 
      mentally, and spiritually and exploring beliefs about pets dying. This article
      also addresses veterinarians' relationships to pets and owners and their role as 
      facilitator; studying the ethics of end-of-life-treatment; referring owners to
      other specialists; and taking care of staff.
CI  - 2011 Elsevier Inc. All rights reserved.
FAU - Akashi, Azaria
AU  - Akashi A
AD  - aakashi@columbus.rr.com
LA  - eng
PT  - Journal Article
DEP - 20110422
PL  - United States
TA  - Vet Clin North Am Small Anim Pract
JT  - The Veterinary clinics of North America. Small animal practice
JID - 7809942
SB  - IM
MH  - Animals
MH  - Decision Making
MH  - Ethics, Medical
MH  - Hospice Care
MH  - Humans
MH  - Palliative Care
MH  - *Professional Role
MH  - *Professional-Patient Relations
MH  - Veterinarians/*psychology
MH  - Veterinary Medicine/*methods
EDAT- 2011/05/24 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/05/24 06:00
PHST- 2011/05/24 06:00 [entrez]
PHST- 2011/05/24 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - S0195-5616(11)00037-4 [pii]
AID - 10.1016/j.cvsm.2011.03.012 [doi]
PST - ppublish
SO  - Vet Clin North Am Small Anim Pract. 2011 May;41(3):647-9. doi:
      10.1016/j.cvsm.2011.03.012. Epub 2011 Apr 22.


PMID- 21601681
OWN - NLM
STAT- MEDLINE
DCOM- 20110906
LR  - 20110523
IS  - 1557-7988 (Electronic)
IS  - 0076-6879 (Linking)
VI  - 498
DP  - 2011
TI  - Industrial scale gene synthesis.
PG  - 247-75
LID - 10.1016/B978-0-12-385120-8.00011-5 [doi]
AB  - The most recent developments in the area of deep DNA sequencing and downstream
      quantitative and functional analysis are rapidly adding a new dimension to
      understanding biochemical pathways and metabolic interdependencies. These
      increasing insights pave the way to designing new strategies that address public 
      needs, including environmental applications and therapeutic inventions, or novel 
      cell factories for sustainable and reconcilable energy or chemicals sources.
      Adding yet another level is building upon nonnaturally occurring networks and
      pathways. Recent developments in synthetic biology have created economic and
      reliable options for designing and synthesizing genes, operons, and eventually
      complete genomes. Meanwhile, high-throughput design and synthesis of extremely
      comprehensive DNA sequences have evolved into an enabling technology already
      indispensable in various life science sectors today. Here, we describe the
      industrial perspective of modern gene synthesis and its relationship with
      synthetic biology. Gene synthesis contributed significantly to the emergence of
      synthetic biology by not only providing the genetic material in high quality and 
      quantity but also enabling its assembly, according to engineering design
      principles, in a standardized format. Synthetic biology on the other hand, added 
      the need for assembling complex circuits and large complexes, thus fostering the 
      development of appropriate methods and expanding the scope of applications.
      Synthetic biology has also stimulated interdisciplinary collaboration as well as 
      integration of the broader public by addressing socioeconomic, philosophical,
      ethical, political, and legal opportunities and concerns. The demand-driven
      technological achievements of gene synthesis and the implemented processes are
      exemplified by an industrial setting of large-scale gene synthesis, describing
      production from order to delivery.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Notka, Frank
AU  - Notka F
AD  - Life Technologies Inc./GeneArt AG, Regensburg, Germany.
FAU - Liss, Michael
AU  - Liss M
FAU - Wagner, Ralf
AU  - Wagner R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Methods Enzymol
JT  - Methods in enzymology
JID - 0212271
RN  - 0 (Oligonucleotides)
RN  - 0 (Proteins)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - *Genes, Synthetic
MH  - Genetic Engineering/*methods
MH  - Humans
MH  - *Industry
MH  - Oligonucleotides/*chemical synthesis/genetics/metabolism
MH  - Proteins/genetics/metabolism
EDAT- 2011/05/24 06:00
MHDA- 2011/09/07 06:00
CRDT- 2011/05/24 06:00
PHST- 2011/05/24 06:00 [entrez]
PHST- 2011/05/24 06:00 [pubmed]
PHST- 2011/09/07 06:00 [medline]
AID - B978-0-12-385120-8.00011-5 [pii]
AID - 10.1016/B978-0-12-385120-8.00011-5 [doi]
PST - ppublish
SO  - Methods Enzymol. 2011;498:247-75. doi: 10.1016/B978-0-12-385120-8.00011-5.


PMID- 21601679
OWN - NLM
STAT- MEDLINE
DCOM- 20110906
LR  - 20110916
IS  - 1557-7988 (Electronic)
IS  - 0076-6879 (Linking)
VI  - 498
DP  - 2011
TI  - Methods for open innovation on a genome-design platform associating scientific,
      commercial, and educational communities in synthetic biology.
PG  - 189-203
LID - 10.1016/B978-0-12-385120-8.00009-7 [doi]
AB  - Synthetic biology requires both engineering efficiency and compliance with safety
      guidelines and ethics. Focusing on the rational construction of biological
      systems based on engineering principles, synthetic biology depends on a
      genome-design platform to explore the combinations of multiple biological
      components or BIO bricks for quickly producing innovative devices. This chapter
      explains the differences among various platform models and details a methodology 
      for promoting open innovation within the scope of the statutory exemption of
      patent laws. The detailed platform adopts a centralized evaluation model (CEM),
      computer-aided design (CAD) bricks, and a freemium model. It is also important
      for the platform to support the legal aspects of copyrights as well as patent and
      safety guidelines because intellectual work including DNA sequences designed
      rationally by human intelligence is basically copyrightable. An informational
      platform with high traceability, transparency, auditability, and security is
      required for copyright proof, safety compliance, and incentive management for
      open innovation in synthetic biology. GenoCon, which we have organized and
      explained here, is a competition-styled, open-innovation method involving
      worldwide participants from scientific, commercial, and educational communities
      that aims to improve the designs of genomic sequences that confer a desired
      function on an organism. Using only a Web browser, a participating contributor
      proposes a design expressed with CAD bricks that generate a relevant DNA
      sequence, which is then experimentally and intensively evaluated by the GenoCon
      organizers. The CAD bricks that comprise programs and databases as a Semantic Web
      are developed, executed, shared, reused, and well stocked on the secure Semantic 
      Web platform called the Scientists' Networking System or SciNetS/SciNeS, based on
      which a CEM research center for synthetic biology and open innovation should be
      established.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Toyoda, Tetsuro
AU  - Toyoda T
AD  - Bioinformatics and Systems Engineering division, RIKEN, Yokohama, Kanagawa,
      Japan.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Methods Enzymol
JT  - Methods in enzymology
JID - 0212271
SB  - IM
MH  - Base Sequence
MH  - *Computer-Aided Design
MH  - Copyright
MH  - Genetic Engineering/*instrumentation/legislation & jurisprudence/*methods
MH  - *Genome
MH  - Humans
MH  - Internet
MH  - Organisms, Genetically Modified/genetics
MH  - Research Personnel
MH  - *Software
MH  - Synthetic Biology/*instrumentation/*methods
EDAT- 2011/05/24 06:00
MHDA- 2011/09/07 06:00
CRDT- 2011/05/24 06:00
PHST- 2011/05/24 06:00 [entrez]
PHST- 2011/05/24 06:00 [pubmed]
PHST- 2011/09/07 06:00 [medline]
AID - B978-0-12-385120-8.00009-7 [pii]
AID - 10.1016/B978-0-12-385120-8.00009-7 [doi]
PST - ppublish
SO  - Methods Enzymol. 2011;498:189-203. doi: 10.1016/B978-0-12-385120-8.00009-7.


PMID- 21601666
OWN - NLM
STAT- MEDLINE
DCOM- 20110728
LR  - 20191210
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 95
IP  - 7
DP  - 2011 Jun
TI  - Ethical application of Shared Risk programs in assisted reproductive technology.
PG  - 2198-9
LID - 10.1016/j.fertnstert.2011.01.174 [doi]
AB  - Shared Risk programs require adherence to core principles: transparency, patient 
      autonomy, and appropriate medical care. These programs improve utilization of and
      perseverance with fertility treatment, receiving strong patient endorsements.
CI  - Copyright (c) 2011 American Society for Reproductive Medicine. Published by
      Elsevier Inc. All rights reserved.
FAU - Levens, Eric D
AU  - Levens ED
AD  - Shady Grove Fertility Reproductive Science Center, Rockville, Maryland 20850,
      USA.
FAU - Levy, Michael J
AU  - Levy MJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
SB  - IM
CIN - Fertil Steril. 2011 Jun;95(7):2192-7. PMID: 20655522
MH  - Contracts/ethics
MH  - Embryo Transfer/economics/ethics
MH  - Female
MH  - Fertilization in Vitro/economics/ethics
MH  - Health Care Costs/*ethics
MH  - Humans
MH  - Outcome and Process Assessment, Health Care/economics/*ethics
MH  - Patient Satisfaction
MH  - Pregnancy
MH  - Pregnancy Outcome
MH  - Pregnancy Rate
MH  - Program Development
MH  - Reproductive Techniques, Assisted/adverse effects/economics/*ethics
MH  - Risk Assessment
MH  - Risk Factors
MH  - Risk Sharing, Financial/*ethics
EDAT- 2011/05/24 06:00
MHDA- 2011/07/29 06:00
CRDT- 2011/05/24 06:00
PHST- 2011/01/04 00:00 [received]
PHST- 2011/01/10 00:00 [accepted]
PHST- 2011/05/24 06:00 [entrez]
PHST- 2011/05/24 06:00 [pubmed]
PHST- 2011/07/29 06:00 [medline]
AID - S0015-0282(11)00607-8 [pii]
AID - 10.1016/j.fertnstert.2011.01.174 [doi]
PST - ppublish
SO  - Fertil Steril. 2011 Jun;95(7):2198-9. doi: 10.1016/j.fertnstert.2011.01.174.


PMID- 21601331
OWN - NLM
STAT- MEDLINE
DCOM- 20110829
LR  - 20110620
IS  - 1523-6838 (Electronic)
IS  - 0272-6386 (Linking)
VI  - 58
IP  - 1
DP  - 2011 Jul
TI  - When enough is enough: the nephrologist's responsibility in ordering dialysis
      treatments.
PG  - 135-43
LID - 10.1053/j.ajkd.2011.03.019 [doi]
AB  - For more than 20 years, nephrologists have been reporting that they are
      increasingly being expected to dialyze patients whom they believe may receive
      little benefit from dialysis therapy. During this time, there has been
      substantial research about the outcomes of patients of differing ages and
      comorbid conditions requiring dialysis and the development of clinical practice
      guidelines for dialysis decision making based on research evidence, ethics, and
      the law. The importance of palliative medicine to the care of the patient
      throughout the continuum of kidney disease also has been recognized, and its
      application has been described. This article summarizes these advances and
      provides an approach for decision making and treatment for patients who are not
      likely to benefit from dialysis therapy.
CI  - Copyright (c) 2011 National Kidney Foundation, Inc. Published by Elsevier Inc.
      All rights reserved.
FAU - Germain, Michael J
AU  - Germain MJ
AD  - Division of Nephrology, Baystate Medical Center and Tufts University,
      Springfield, MA, USA. michael.germain@baystatehealth.org
FAU - Davison, Sara N
AU  - Davison SN
FAU - Moss, Alvin H
AU  - Moss AH
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20110520
PL  - United States
TA  - Am J Kidney Dis
JT  - American journal of kidney diseases : the official journal of the National Kidney
      Foundation
JID - 8110075
SB  - IM
MH  - Aged, 80 and over
MH  - Decision Making/ethics
MH  - Humans
MH  - Kidney Failure, Chronic/*therapy
MH  - Male
MH  - Nephrology/*ethics
MH  - Palliative Care/*ethics/legislation & jurisprudence
MH  - Patient Preference
MH  - *Physician's Role
MH  - Physician-Patient Relations
MH  - Practice Guidelines as Topic
MH  - Professional-Family Relations
MH  - Prognosis
MH  - Quality of Life
MH  - Renal Dialysis/*ethics
MH  - Renal Insufficiency, Chronic/*therapy
MH  - Withholding Treatment/ethics/legislation & jurisprudence
EDAT- 2011/05/24 06:00
MHDA- 2011/08/30 06:00
CRDT- 2011/05/24 06:00
PHST- 2011/01/20 00:00 [received]
PHST- 2011/03/18 00:00 [accepted]
PHST- 2011/05/24 06:00 [entrez]
PHST- 2011/05/24 06:00 [pubmed]
PHST- 2011/08/30 06:00 [medline]
AID - S0272-6386(11)00738-4 [pii]
AID - 10.1053/j.ajkd.2011.03.019 [doi]
PST - ppublish
SO  - Am J Kidney Dis. 2011 Jul;58(1):135-43. doi: 10.1053/j.ajkd.2011.03.019. Epub
      2011 May 20.


PMID- 21600362
OWN - NLM
STAT- MEDLINE
DCOM- 20110722
LR  - 20110523
IS  - 1532-8708 (Electronic)
IS  - 0093-7754 (Linking)
VI  - 38
IP  - 3
DP  - 2011 Jun
TI  - Best supportive care: a euphemism for no care or a standard of good care?
PG  - 351-7
LID - 10.1053/j.seminoncol.2011.03.002 [doi]
AB  - This article seeks to address the question: Is best supportive care (BSC) in
      research a euphemism for no care or a standard of good care? The data regarding
      the ethical and methodological validity of BSC studies are reviewed. Most of the 
      BSC studies published over the past 25 years are really treatment versus no
      treatment studies represented as BSC studies. By ignoring the best
      contemporaneous standards of BSC, standardizing practices in multicenter studies,
      validating participating centers, or documenting treatment delivery, researchers 
      belie the stated intention of studying BSC. Most studies sought to evaluate if
      there was any benefit of a new anti-tumor treatment versus discontinuation of
      anti-tumor therapies. Overwhelmingly, and with few exceptions, the impact of BSC 
      practices was not really part of the key research question. To be ethical and
      methodologically valid, BSC studies must incorporate standards consistent with
      contemporaneous, proven BSC practice standards. Work is underway to develop
      widely validated standards of practice for the control arm of best supportive
      care studies. These can be readily incorporated in to study development and
      evaluation.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Cherny, Nathan
AU  - Cherny N
AD  - Cancer Pain and Palliative Medicine Service, Department of Medical Oncology,
      Shaare Zedek Medical Center, Jerusalem, Israel. chernyn@etvision.net.il
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Semin Oncol
JT  - Seminars in oncology
JID - 0420432
SB  - IM
MH  - *Clinical Trials as Topic/ethics/standards
MH  - *Comprehensive Health Care
MH  - Ethics, Research
MH  - Humans
MH  - Neoplasms/*therapy
MH  - *Quality of Life
MH  - Reproducibility of Results
MH  - Research Design
MH  - *Standard of Care
EDAT- 2011/05/24 06:00
MHDA- 2011/07/23 06:00
CRDT- 2011/05/24 06:00
PHST- 2011/05/24 06:00 [entrez]
PHST- 2011/05/24 06:00 [pubmed]
PHST- 2011/07/23 06:00 [medline]
AID - S0093-7754(11)00072-8 [pii]
AID - 10.1053/j.seminoncol.2011.03.002 [doi]
PST - ppublish
SO  - Semin Oncol. 2011 Jun;38(3):351-7. doi: 10.1053/j.seminoncol.2011.03.002.


PMID- 21600163
OWN - NLM
STAT- MEDLINE
DCOM- 20111128
LR  - 20181201
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 91
IP  - 12
DP  - 2011 Mar 29
TI  - [A comparison of remifentanil versus sufentanil with target-controlled infusion
      in combined inhalation anesthesia for surgical patients: effects on hemodynamics 
      and postoperative recovery].
PG  - 828-31
AB  - OBJECTIVE: To compare the effect of remifentanil versus sufentanil with
      target-controlled infusion in combination with inhalation anesthesia for surgical
      patients on the parameters of hemodynamics and postoperative recovery. METHODS:
      Forty ASA I-II patients aged 18 - 65 years old with BMI (body mass index) < 30,
      undergoing colectomy or pedical screw interfix were enrolled. Upon the approval
      of institutional Ethics Committee, they were randomized to receive remifentanil
      or sufentanil at a target plasma concentration of 3 ng/ml and 0.3 ng/ml
      respectively in combination of inhalated anesthesia at 0.9 MAC (minimal alveolar 
      concentration). The infusion of remifentanil was discontinued at the end of
      surgery while the infusion of sufentanil at 40 - 60 minutes before the end of
      surgery. The arterial blood pressure (ABP), heart rate (HR), electrocardiogram
      (ECG) and pulse blood oxygen saturation during anesthesia were monitored. The
      time between the termination of anesthetic use and recovery of spontaneous
      breathing and extubation were observed. And the incidence of postoperative pain
      and respiratory depression were recorded. RESULTS: As compared with the baseline 
      values, BP and HR decreased significantly in both groups. BP was similar in both 
      groups whereas HR was lower in Group R than that in Group S at post-induction,
      post-intubation, incision, the end of surgery and extubation (P < 0.05). The time
      from termination of anesthesia to recovery of spontaneous breathing was 1.8 +/-
      1.4 min in Group R. And it was significantly shorter than that in Group S (2.9
      +/- 1.5 min) (P < 0.05). The time from termination of anesthetic use to
      extubation was 6.8 +/- 3.9 min in Group R. And it was also significantly shorter 
      than that in Group S (9.1 +/- 2.8 min) (P < 0.05). Seven patients experienced
      postoperative pain with visual analogue scale (VAS) > 4. And morphine was used
      for rescue analgesia in recovery room. CONCLUSION: When combined with inhalation 
      anesthesia, the effects on hemodynamics are similar between the patients
      receiving the target-controlled infusions of remifentanil and sufentanil.
      Remifentanil offers a shorter time to recovery of spontaneous breathing and
      tracheal extubation.
FAU - Yang, Xue-yuan
AU  - Yang XY
AD  - Department of Anesthesiology, First Peking University Hospital, Beijing 100034,
      China. yang81211978@sohu.com
FAU - Xu, Xing
AU  - Xu X
FAU - Wu, Xin-min
AU  - Wu XM
LA  - chi
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 0 (Anesthetics, Inhalation)
RN  - 0 (Piperidines)
RN  - AFE2YW0IIZ (Sufentanil)
RN  - P10582JYYK (Remifentanil)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Anesthesia Recovery Period
MH  - Anesthesia, Intravenous
MH  - Anesthetics, Inhalation
MH  - Blood Pressure
MH  - Female
MH  - Heart Rate
MH  - Hemodynamics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Piperidines/*administration & dosage
MH  - Remifentanil
MH  - Sufentanil/*administration & dosage
MH  - Young Adult
EDAT- 2011/05/24 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/05/24 06:00
PHST- 2011/05/24 06:00 [entrez]
PHST- 2011/05/24 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2011 Mar 29;91(12):828-31.


PMID- 21600129
OWN - NLM
STAT- MEDLINE
DCOM- 20111205
LR  - 20131121
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 91
IP  - 9
DP  - 2011 Mar 8
TI  - [A comparison of target controlled versus manually controlled infusion of
      propofol in elderly patients].
PG  - 600-3
AB  - OBJECTIVE: To evaluate the impact of anesthesia via target-controlled infusion
      (TCI) on drug consumption, intraoperative hemodynamic stability and recovery
      compared with manual-controlled infusion (MCI) in elderly patients. METHODS:
      Under the approval of the hospital ethics committee, 60 elderly patients
      undergoing laparoscopic surgery were randomly allocated by random numbers to
      either the MCI group (n = 30) or the TCI group (n = 30). The patients in MCI
      group received an infusion of propofol at 200 ml/h while those in TCI group
      propofol at an initial plasma concentration of 2.0 microg/ml and titrated upwards
      by 0.5 microg/ml steps until loss of consciousness. Both groups received an
      infusion of remifentanil. After intubation, the infusion rate or the target
      concentration of propofol was titrated to maintain BIS (bispectral index) values 
      between 40 and 60. The infusion of remifentanil was adapted to intraoperative
      hemodynamics. The doses of propofol and remifentanil were recorded, the
      hemodynamic parameters and the use of vasoactive drugs collected and the recovery
      times assessed. RESULTS: The time of loss of consciousness and the time to
      intubation, the doses of propofol and remifentanil during induction and
      maintenance were not significantly different between two groups. The times of
      pump adjustment were less in TCI group versus MCI group [(5.8 +/- 2.1) vs (7.8
      +/- 3.7) times, P < 0.01]. Blood pressure and heart rates were not statistically 
      different at any time point between two groups. There were no significant
      differences in BIS or the use of vasoactive drugs between two groups. The
      recovery times were similar for two groups. CONCLUSION: Although target infusion 
      system is easy to use and requires less time of adjustment, it fails to show
      added benefit on propofol consumption, hemodynamic stability, anesthesia depth
      and recovery in elderly patients.
FAU - Li, Min
AU  - Li M
AD  - Department of Anesthesiology, Peking University Third Hospital, Beijing 100191,
      China.
FAU - Xu, Chuan-ya
AU  - Xu CY
FAU - Wang, Xue-dong
AU  - Wang XD
FAU - Zhang, Li-ping
AU  - Zhang LP
FAU - Guo, Xiang-yang
AU  - Guo XY
LA  - chi
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - YI7VU623SF (Propofol)
SB  - IM
MH  - Aged
MH  - Anesthesia, Intravenous
MH  - Female
MH  - Humans
MH  - *Infusion Pumps
MH  - Infusions, Intravenous/*instrumentation
MH  - Male
MH  - Propofol/*administration & dosage
EDAT- 2011/05/24 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/05/24 06:00
PHST- 2011/05/24 06:00 [entrez]
PHST- 2011/05/24 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2011 Mar 8;91(9):600-3.


PMID- 21600104
OWN - NLM
STAT- MEDLINE
DCOM- 20111205
LR  - 20181201
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 91
IP  - 11
DP  - 2011 Mar 22
TI  - [Effect of remifentanil or esmolol on stress response during electric shock
      therapy in psychiatric patients].
PG  - 769-71
AB  - OBJECTIVE: To observe the effects of remifentanil or esmolol on the stress
      responses during electric shock therapy in psychiatric patients. METHODS: Upon
      the approval of institutional Ethics Committee, Eighty psychiatric patients
      requiring electric shock therapy were randomly divided into 2 groups:esmolol
      group (Group E) and remifentanil group (Group R) (n = 40 each). The patients in
      Groups E and R were injected with esmolol 1 mg/kg or remifentanil 2 microg/kg
      respectively before induction of anesthesia. Electric shock therapy was performed
      after a disappearance of fasciculation. MAP (mean arterial pressure) and HR
      (heart rate) were recorded at the following time points:prior to anesthesia (T0),
      prior to electric shock therapy (T1) and at 1 min (T2), 3 min (T3) & 5 min (T4)
      after electric shock therapy. Venous blood samples were collected at (T0) and
      (T4). The plasma levels of cortisol and norepinephrine were determined by
      enzyme-linked immunosorbent assay. RESULTS: The levels of MAP and HR at T2, T3
      were significantly higher than those at T0 in Group E (P < 0.05). And the levels 
      of cortisol and norepinephrine at T4 were significantly higher than those at T0
      in 2 groups (P < 0.05). However, their levels were significantly higher in Group 
      E than those in Group R (P > 0.05). CONCLUSION: In modified electric convulsive
      treatment, remifentanil is superior to esmolol in maintaining the stabilization
      of cardiovascular system and effectively inhibiting the stress responses.
FAU - Guan, Lei
AU  - Guan L
AD  - Department of Anesthesioloy, Century Altar Hospital of Beijing, Beijing 100038,
      China.
FAU - Guo, Xiang-yang
AU  - Guo XY
FAU - Li, Qun
AU  - Li Q
LA  - chi
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 0 (Piperidines)
RN  - 0 (Propanolamines)
RN  - MDY902UXSR (esmolol)
RN  - P10582JYYK (Remifentanil)
SB  - IM
MH  - Adult
MH  - Blood Pressure
MH  - Electroconvulsive Therapy/*adverse effects
MH  - Female
MH  - Heart Rate
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Piperidines/*therapeutic use
MH  - Propanolamines/*therapeutic use
MH  - Psychotic Disorders/*therapy
MH  - Remifentanil
MH  - Stress, Physiological/*drug effects
MH  - Young Adult
EDAT- 2011/05/24 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/05/24 06:00
PHST- 2011/05/24 06:00 [entrez]
PHST- 2011/05/24 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2011 Mar 22;91(11):769-71.


PMID- 21599860
OWN - NLM
STAT- MEDLINE
DCOM- 20110916
LR  - 20120109
IS  - 1747-0803 (Electronic)
IS  - 1747-079X (Linking)
VI  - 6
IP  - 3
DP  - 2011 May-Jun
TI  - Marketing code of ethics for pediatric cardiology programs.
PG  - 209-10
LID - 10.1111/j.1747-0803.2011.00523.x [doi]
FAU - Walsh, Edward P
AU  - Walsh EP
AD  - Department of Cardiology, Children's Hospital Boston, Boston, MA, 02115, USA.
      ed.walsh@cardio.chboston.org
FAU - Newburger, Jane W
AU  - Newburger JW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Congenit Heart Dis
JT  - Congenital heart disease
JID - 101256510
SB  - IM
MH  - Attitude of Health Personnel
MH  - Cardiology/*ethics
MH  - *Codes of Ethics
MH  - Guidelines as Topic
MH  - Humans
MH  - Marketing of Health Services/*ethics
MH  - North America
MH  - Pediatrics/*ethics
MH  - Professional Misconduct
MH  - Program Development
MH  - Truth Disclosure
EDAT- 2011/05/24 06:00
MHDA- 2011/09/17 06:00
CRDT- 2011/05/24 06:00
PHST- 2011/05/24 06:00 [entrez]
PHST- 2011/05/24 06:00 [pubmed]
PHST- 2011/09/17 06:00 [medline]
AID - 10.1111/j.1747-0803.2011.00523.x [doi]
PST - ppublish
SO  - Congenit Heart Dis. 2011 May-Jun;6(3):209-10. doi:
      10.1111/j.1747-0803.2011.00523.x.


PMID- 21598846
OWN - NLM
STAT- MEDLINE
DCOM- 20110603
LR  - 20191210
IS  - 1054-6863 (Print)
IS  - 1054-6863 (Linking)
VI  - 21
IP  - 1
DP  - 2011 Mar
TI  - Early stopping of clinical trials: charting the ethical terrain.
PG  - 51-78
AB  - The decision to terminate a clinical trial earlier than planned is often
      described as ethically problematic, but it is rarely systematically analyzed as
      an ethical issue in its own right. This paper provides an overview of the main
      ethical considerations at stake in such decisions and of the main tensions
      between these considerations. Arguments about informed consent and the impact of 
      early stopping on research and society are explored. We devote particular
      attention to a familiar conflict that arises with special urgency when early data
      suggest that the experimental treatment is superior. Should the trial be stopped 
      so that participants in the control group will not be allocated a seemingly
      inferior treatment, or should it continue in pursuit of evidence conclusive
      enough to improve the care of future patients? We scrutinize three ways to
      address this problem. Rather than dissolving the tension, they represent
      different trade-offs between the respective welfare interests of subjects and
      future patients.
FAU - Malmqvist, Erik
AU  - Malmqvist E
AD  - Centre for Research on Meaning, Ethics and Society, Universite Paris Descartes,
      France.
FAU - Juth, Niklas
AU  - Juth N
FAU - Lynoe, Niels
AU  - Lynoe N
FAU - Helgesson, Gert
AU  - Helgesson G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Kennedy Inst Ethics J
JT  - Kennedy Institute of Ethics journal
JID - 9109135
SB  - IM
MH  - Clinical Trials, Phase III as Topic/economics/*ethics
MH  - Conflict, Psychological
MH  - Double-Blind Method
MH  - Ethics, Research
MH  - *Evidence-Based Medicine/standards/trends
MH  - Humans
MH  - *Informed Consent/ethics
MH  - Randomized Controlled Trials as Topic/economics/*ethics
MH  - *Research Subjects
MH  - Safety
MH  - *Therapeutic Equipoise
MH  - Therapeutic Misconception
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2011/05/24 06:00
MHDA- 2011/06/04 06:00
CRDT- 2011/05/24 06:00
PHST- 2011/05/24 06:00 [entrez]
PHST- 2011/05/24 06:00 [pubmed]
PHST- 2011/06/04 06:00 [medline]
AID - 10.1353/ken.2011.0002 [doi]
PST - ppublish
SO  - Kennedy Inst Ethics J. 2011 Mar;21(1):51-78. doi: 10.1353/ken.2011.0002.


PMID- 21598845
OWN - NLM
STAT- MEDLINE
DCOM- 20110603
LR  - 20191112
IS  - 1054-6863 (Print)
IS  - 1054-6863 (Linking)
VI  - 21
IP  - 1
DP  - 2011 Mar
TI  - Board oversight of community benefit: an ethical imperative.
PG  - 25-50
AB  - Board oversight of community benefit responsibility in tax-exempt organizations
      in the nonprofit health care sector is attracting considerable attention.
      Scrutiny by the IRS and other official bodies has led to stricter measures of
      compliance with the community benefit standard. But stricter compliance does not 
      sufficiently engage the underlying ethical imperative for boards to provide
      effective oversight--an imperative that recent research suggests has not been
      sufficiently honored. This analysis considers why there is a distinctively
      ethical imperative for board oversight, the organizational nature of the
      imperative involved, and practical ways to fulfill its obligations. We adopt an
      organizational ethics paradigm to illuminate the constituent components of the
      ethical imperative and to clarify emerging benchmarks as flexible guidelines. As 
      these emerging benchmarks enhance board oversight of community benefit they also 
      can shed light on what it means to be a virtuous organization.
FAU - Magill, Gerard
AU  - Magill G
AD  - Center for Healthcare Ethics, Duquesne University, USA.
FAU - Prybil, Lawrence D
AU  - Prybil LD
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Kennedy Inst Ethics J
JT  - Kennedy Institute of Ethics journal
JID - 9109135
SB  - IM
MH  - Benchmarking
MH  - *Ethics, Institutional
MH  - Governing Board/*ethics
MH  - Health Care Sector/economics/*ethics
MH  - Humans
MH  - Organizations, Nonprofit/economics/*ethics/organization & administration
MH  - *Residence Characteristics
MH  - Tax Exemption/economics
MH  - United States
EDAT- 2011/05/24 06:00
MHDA- 2011/06/04 06:00
CRDT- 2011/05/24 06:00
PHST- 2011/05/24 06:00 [entrez]
PHST- 2011/05/24 06:00 [pubmed]
PHST- 2011/06/04 06:00 [medline]
AID - 10.1353/ken.2011.0001 [doi]
PST - ppublish
SO  - Kennedy Inst Ethics J. 2011 Mar;21(1):25-50. doi: 10.1353/ken.2011.0001.


PMID- 21598050
OWN - NLM
STAT- MEDLINE
DCOM- 20111212
LR  - 20211020
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 23
IP  - 2
DP  - 2011 Jun
TI  - Ethical concerns regarding operations by volunteer surgeons on vulnerable patient
      groups: the case of women with obstetric fistulas.
PG  - 115-27
LID - 10.1007/s10730-011-9153-x [doi]
AB  - By their very nature, overseas medical missions (and even domestic medical
      charities such as "free clinics") are designed to serve "vulnerable populations."
      If these groups were capable of protecting their own interests, they would not
      need the help of medical volunteers: their medical needs would be met through
      existing government health programs or by utilizing their own resources. Medical 
      volunteerism thus seems like an unfettered good: a charitable activity provided
      by well-meaning doctors and nurses who want to give of their time, skills, and
      resources to help those who would not otherwise be able to take care of their
      medical needs. In this article, I argue that if medical volunteerism is to be
      "good," however, it must always meet certain basic ethical requirements. These
      requirements may be (and perhaps often are) overlooked in the rush to organize
      and carry out short-term medical missions. I illustrate my point with special
      reference to short-term medical missions designed to provide surgical repair of
      obstetric vesico-vaginal fistula, a condition in which the tissues that normally 
      separate the bladder from the vagina are destroyed by obstetric trauma, leading
      to continuous and unremitting incontinence in the affected woman.
FAU - Wall, L Lewis
AU  - Wall LL
AD  - Department of Obstetrics & Gynecology, Washington University School of Medicine, 
      Campus Box 8064, 660 South Euclid Avenue, St. Louis, MO 63110, USA.
      WALLL@wustl.edu
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - Female
MH  - General Surgery/*ethics
MH  - Humans
MH  - Medical Missions/*ethics
MH  - *Obstetrics
MH  - *Physicians
MH  - Vesicovaginal Fistula/*surgery
MH  - *Volunteers
EDAT- 2011/05/21 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/05/21 06:00
PHST- 2011/05/21 06:00 [entrez]
PHST- 2011/05/21 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 10.1007/s10730-011-9153-x [doi]
PST - ppublish
SO  - HEC Forum. 2011 Jun;23(2):115-27. doi: 10.1007/s10730-011-9153-x.


PMID- 21598049
OWN - NLM
STAT- MEDLINE
DCOM- 20111212
LR  - 20211020
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 23
IP  - 2
DP  - 2011 Jun
TI  - Ethical issues of medical missions: the clinicians' view.
PG  - 105-13
LID - 10.1007/s10730-011-9154-9 [doi]
AB  - Surgery is an important part of health care worldwide. Without access to surgical
      treatments, morbidity and mortality increase. Access to surgical treatment is a
      significant problem in global public health because surgical services are not
      equally distributed in the world. There is a disproportionate scarcity of
      surgical access in low-income countries. There are many charitable organizations 
      around the world that sponsor surgical missions to under served nations. One such
      organization is Operation Smile International, a group with which both authors
      have volunteered. This paper will describe the purpose and processes involved in 
      Operation Smile and identify some of the key ethical issues that arise in short
      term medical volunteer work highlighting the importance of sustainability.
FAU - Ott, Barbara B
AU  - Ott BB
AD  - College of Nursing, Villanova University, Villanova, PA, USA.
      barbara.ott@villanova.edu
FAU - Olson, Robert M
AU  - Olson RM
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - Cleft Lip/surgery
MH  - Cleft Palate/surgery
MH  - Developing Countries
MH  - General Surgery
MH  - Health Personnel/*psychology
MH  - Humans
MH  - Informed Consent
MH  - Mass Screening
MH  - Medical Missions/*ethics/organization & administration
EDAT- 2011/05/21 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/05/21 06:00
PHST- 2011/05/21 06:00 [entrez]
PHST- 2011/05/21 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 10.1007/s10730-011-9154-9 [doi]
PST - ppublish
SO  - HEC Forum. 2011 Jun;23(2):105-13. doi: 10.1007/s10730-011-9154-9.


PMID- 21597907
OWN - NLM
STAT- MEDLINE
DCOM- 20110919
LR  - 20211020
IS  - 1573-0980 (Electronic)
IS  - 1386-7415 (Linking)
VI  - 32
IP  - 4
DP  - 2011 Aug
TI  - Double effect, all over again: the case of Sister Margaret McBride.
PG  - 271-83
LID - 10.1007/s11017-011-9183-z [doi]
AB  - As media reports have made widely known, in November 2009, the ethics committee
      of St. Joseph's Hospital in Phoenix, Arizona, permitted the abortion of an
      eleven-week-old fetus in order to save the life of its mother. This woman was
      suffering from acute pulmonary hypertension, which her doctors judged would prove
      fatal for both her and her previable child. The ethics committee believed
      abortion to be permitted in this case under the so-called principle of double
      effect, but Thomas J. Olmsted, the bishop of Phoenix, disagreed with the
      committee and pronounced its chair, Sister Margaret McBride, excommunicated latae
      sententiae, "by the very commission of the act." In this article, I take the much
      discussed Phoenix case as an occasion to subject the principle of double effect
      to another round of philosophical scrutiny. In particular, I examine the third
      condition of the principle in its textbook formulation, namely, that the evil
      effect in question may not be the means to the good effect. My argument, in
      brief, is that the textbook formulation of the principle does not withstand
      philosophical scrutiny. Nevertheless, in the end, I do not claim that we should
      then "do away" with the principle altogether. Instead, we do well to understand
      it within the context of casuistry, the tradition of moral reasoning from which
      it issued.
FAU - Prusak, Bernard G
AU  - Prusak BG
AD  - Center for Liberal Education, Villanova University, 800 Lancaster Ave.,
      Villanova, PA 19085, USA. bernard.g.prusak@villanova.edu
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Theor Med Bioeth
JT  - Theoretical medicine and bioethics
JID - 9805378
SB  - IM
MH  - Abortion, Therapeutic/*ethics
MH  - *Catholicism
MH  - *Double Effect Principle
MH  - Ethical Analysis
MH  - Ethical Theory
MH  - Female
MH  - Gestational Age
MH  - *Guideline Adherence/ethics
MH  - Guidelines as Topic
MH  - Hospitals, Religious/*standards
MH  - Humans
MH  - *Hypertension, Pulmonary
MH  - Philosophy
MH  - Pregnancy
MH  - *Pregnancy Complications
MH  - Religion and Medicine
EDAT- 2011/05/21 06:00
MHDA- 2011/09/20 06:00
CRDT- 2011/05/21 06:00
PHST- 2011/05/21 06:00 [entrez]
PHST- 2011/05/21 06:00 [pubmed]
PHST- 2011/09/20 06:00 [medline]
AID - 10.1007/s11017-011-9183-z [doi]
PST - ppublish
SO  - Theor Med Bioeth. 2011 Aug;32(4):271-83. doi: 10.1007/s11017-011-9183-z.


PMID- 21597539
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20111117
IS  - 0300-8495 (Print)
IS  - 0300-8495 (Linking)
VI  - 40
IP  - 4
DP  - 2011 Apr
TI  - Capacity to consent to treatment.
PG  - 249-50
AB  - A competent adult patient has an ethical and legal right to give, or withhold,
      consent to an examination, investigation or treatment. Depending on the nature
      and complexity of an intervention, a patient with an intellectual disability may 
      be capable of consenting to their own medical treatment. In circumstances in
      which an adult patient does not have the capacity to consent, there is specific
      guardianship legislation enacted in each state and territory which provides for
      valid consent by a substitute decision maker.
FAU - Bird, Sara
AU  - Bird S
AD  - Medico-Legal and Advisory Services, MDA National. sbird@mdanational.com.au
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Australia
TA  - Aust Fam Physician
JT  - Australian family physician
JID - 0326701
SB  - IM
MH  - Humans
MH  - *Informed Consent
MH  - Intellectual Disability
MH  - Male
MH  - *Mental Competency
MH  - Middle Aged
EDAT- 2011/05/21 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/05/21 06:00
PHST- 2011/05/21 06:00 [entrez]
PHST- 2011/05/21 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
PST - ppublish
SO  - Aust Fam Physician. 2011 Apr;40(4):249-50.


PMID- 21597110
OWN - NLM
STAT- MEDLINE
DCOM- 20120301
LR  - 20111019
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 11
DP  - 2011 Nov
TI  - Futile treatment, junior doctors and role virtues.
PG  - 646-9
LID - 10.1136/jme.2010.041095 [doi]
AB  - Futile treatment is one ethically challenging situation commonly encountered by
      junior doctors. By analysing an intern's story using a role virtues framework, I 
      propose a set of three steps for junior doctors facing this problem. I claim that
      junior doctors ought always to investigate the rationale underlying decisions to 
      proceed with apparently futile treatment and discuss their concerns with their
      seniors, even if such discussion will be difficult. I also suggest that junior
      doctors facing this ethical challenge ought always to be willing to initiate and 
      engage in ethical dialogue, and that in some situations further action (such as
      taking concerns outside the team or refusing to participate in treatment) may be 
      morally appropriate.
FAU - McDougall, Rosalind
AU  - McDougall R
AD  - Centre for Health and Society, University of Melbourne VIC 3010, Australia.
      rosjmcdougall@gmail.com
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110519
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Clinical Competence/*standards
MH  - Communication
MH  - Education, Medical/*standards
MH  - Humans
MH  - Medical Futility/*ethics/psychology
MH  - Medical Staff, Hospital/*ethics/psychology
MH  - Physician-Patient Relations
MH  - Physicians/*ethics/psychology
EDAT- 2011/05/21 06:00
MHDA- 2012/03/02 06:00
CRDT- 2011/05/21 06:00
PHST- 2011/05/21 06:00 [entrez]
PHST- 2011/05/21 06:00 [pubmed]
PHST- 2012/03/02 06:00 [medline]
AID - jme.2010.041095 [pii]
AID - 10.1136/jme.2010.041095 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Nov;37(11):646-9. doi: 10.1136/jme.2010.041095. Epub 2011 May 
      19.


PMID- 21597109
OWN - NLM
STAT- MEDLINE
DCOM- 20120301
LR  - 20111019
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 11
DP  - 2011 Nov
TI  - The Gettier Problem in informed consent.
PG  - 642-5
LID - 10.1136/jme.2010.041939 [doi]
AB  - The duty to procure informed consent (IC) from patients before any significant
      intervention is among the pillars of medical and research ethics. The provision
      by the doctor of relevant information about treatment and free decision-making by
      the patient are essential elements of IC. The paper presents cases of IC where
      the free decision about treatment is not causally related to the information
      provided, and claims that such cases pose a difficulty parallel to that presented
      by the Gettier Problem in epistemology. In analogy to the original problem with
      the concept of knowledge, these Gettier-type cases show an indeterminacy in the
      concept of IC: we either need to add some explicit additional condition of causal
      connection between information and consent, or else we should understand the
      concept in a new way-specifically, since the practice of autonomy necessarily
      involves some consideration of the relevant information, we must understand free 
      consent in a way that no longer refers to patient autonomy.
FAU - Cohen, Shlomo
AU  - Cohen S
AD  - Department of Philosophy, Hebrew University, Mt Scopus, 91905 Jerusalem, Israel. 
      shlomco@mscc.huji.ac.il
LA  - eng
PT  - Journal Article
DEP - 20110519
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Comprehension
MH  - Decision Making
MH  - *Ethics, Medical
MH  - Humans
MH  - Informed Consent/ethics/*psychology
MH  - Patient Acceptance of Health Care/*psychology
MH  - Personal Autonomy
MH  - Physician-Patient Relations
EDAT- 2011/05/21 06:00
MHDA- 2012/03/02 06:00
CRDT- 2011/05/21 06:00
PHST- 2011/05/21 06:00 [entrez]
PHST- 2011/05/21 06:00 [pubmed]
PHST- 2012/03/02 06:00 [medline]
AID - jme.2010.041939 [pii]
AID - 10.1136/jme.2010.041939 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Nov;37(11):642-5. doi: 10.1136/jme.2010.041939. Epub 2011 May 
      19.


PMID- 21597086
OWN - NLM
STAT- MEDLINE
DCOM- 20111123
LR  - 20181201
IS  - 1744-5019 (Electronic)
IS  - 0360-5310 (Linking)
VI  - 36
IP  - 3
DP  - 2011 Jun
TI  - Euthanasia and common sense: a reply to Garcia.
PG  - 321-7
LID - 10.1093/jmp/jhr016 [doi]
AB  - J. L. A. Garcia holds that my defense of voluntary euthanasia in an earlier paper
      amounts to an "assault on traditional common sense" about what medical ethics
      permits physicians to do, particularly insofar as I hold that a physician's duty 
      to abstain from intentionally killing is only a defeasible duty, not an
      unconditional one. But I argue here that it is Garcia's views that are more at
      odds with common sense, and that voluntary euthanasia is in fact a humane
      alternative that respects patient autonomy and is consistent with the most
      fundamental moral duties of physicians. Among these is a duty to relieve
      suffering, which can sometimes outweigh the fundamental duty to conserve life.
FAU - Seay, Gary
AU  - Seay G
AD  - Medgar Evers College, City University of New York, USA. garys@mec.cuny.edu
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20110519
PL  - United States
TA  - J Med Philos
JT  - The Journal of medicine and philosophy
JID - 7610512
SB  - IM
CON - J Med Philos. 2007 Jan-Feb;32(1):7-24. PMID: 17365443
MH  - Euthanasia/*ethics
MH  - Humans
MH  - *Morals
MH  - *Physician's Role
EDAT- 2011/05/21 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/05/21 06:00
PHST- 2011/05/21 06:00 [entrez]
PHST- 2011/05/21 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - jhr016 [pii]
AID - 10.1093/jmp/jhr016 [doi]
PST - ppublish
SO  - J Med Philos. 2011 Jun;36(3):321-7. doi: 10.1093/jmp/jhr016. Epub 2011 May 19.


PMID- 21597084
OWN - NLM
STAT- MEDLINE
DCOM- 20111123
LR  - 20220408
IS  - 1744-5019 (Electronic)
IS  - 0360-5310 (Linking)
VI  - 36
IP  - 3
DP  - 2011 Jun
TI  - Parental wisdom, empirical blindness, and normative evaluation of prenatal
      genetic enhancement.
PG  - 274-95
LID - 10.1093/jmp/jhr012 [doi]
AB  - The purpose of this paper is to unveil one problem that surrounds the debate over
      the moral standing of prenatal genetic enhancement (PGE) and to outline a
      solution to it. The problem is that we have no way to test our speculations about
      the consequences of prenatal enhancement without begging the question about the
      moral permissibility of enhancing unborn children. The only way to empirically
      support our speculations about the consequences of prenatal enhancement is to
      resort to ethically worrisome (and radical) experimental genetic research. The
      suggested solution to this problem is to focus on the character of good parents. 
      The virtue of parental wisdom is introduced and used as a basis for evaluating
      PGE. It is argued that good parents have good reason not to condone PGE for their
      children (in very many cases), especially as part of the first wave of
      genetically altered humans.
FAU - Tonkens, Ryan
AU  - Tonkens R
AD  - Department of Philosophy, York University, Toronto, Ontario, Canada.
      tonkens@yorku.ca
LA  - eng
PT  - Journal Article
DEP - 20110519
PL  - United States
TA  - J Med Philos
JT  - The Journal of medicine and philosophy
JID - 7610512
SB  - IM
MH  - Bioethics
MH  - Ethics, Medical
MH  - Family Planning Services/ethics
MH  - Forecasting
MH  - Genetic Enhancement/*ethics
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Judgment/*ethics
MH  - Morals
MH  - *Parents
MH  - Personal Autonomy
MH  - Reproductive Techniques, Assisted/*ethics
MH  - Social Perception
EDAT- 2011/05/21 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/05/21 06:00
PHST- 2011/05/21 06:00 [entrez]
PHST- 2011/05/21 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - jhr012 [pii]
AID - 10.1093/jmp/jhr012 [doi]
PST - ppublish
SO  - J Med Philos. 2011 Jun;36(3):274-95. doi: 10.1093/jmp/jhr012. Epub 2011 May 19.


PMID- 21597083
OWN - NLM
STAT- MEDLINE
DCOM- 20111123
LR  - 20110711
IS  - 1744-5019 (Electronic)
IS  - 0360-5310 (Linking)
VI  - 36
IP  - 3
DP  - 2011 Jun
TI  - Abortion, metaphysics and morality: a review of Francis Beckwith's defending
      life: a moral and legal case against abortion choice.
PG  - 261-73
LID - 10.1093/jmp/jhr015 [doi]
AB  - In Defending Life: A Moral and Legal Case Against Abortion Choice (2007) and an
      earlier article in this journal, "Defending Abortion Philosophically"(2006),
      Francis Beckwith argues that fetuses are, from conception, prima facie wrong to
      kill. His arguments are based on what he calls a "metaphysics of the human
      person" known as "The Substance View." I argue that Beckwith's metaphysics does
      not support his abortion ethic: Moral, not metaphysical, claims that are part of 
      this Substance View are the foundation of the argument, and Beckwith inadequately
      defends these moral claims. Thus, Beckwith's arguments do not provide strong
      support for what he calls the "pro-life" view of abortion.
FAU - Nobis, Nathan
AU  - Nobis N
AD  - Morehouse College, Atlanta, GA 30030, USA. nathan.nobis@gmail.com
LA  - eng
PT  - Historical Article
PT  - Journal Article
DEP - 20110519
PL  - United States
TA  - J Med Philos
JT  - The Journal of medicine and philosophy
JID - 7610512
SB  - IM
MH  - Abortion, Legal/*ethics/history
MH  - Attitude to Health
MH  - *Bioethical Issues
MH  - Bioethics
MH  - Ethical Theory
MH  - *Ethics, Medical
MH  - Female
MH  - History, 20th Century
MH  - Humans
MH  - *Metaphysics
MH  - *Moral Obligations
MH  - Personhood
MH  - *Philosophy, Medical
MH  - Pregnancy
MH  - Social Values
MH  - Value of Life
EDAT- 2011/05/21 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/05/21 06:00
PHST- 2011/05/21 06:00 [entrez]
PHST- 2011/05/21 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - jhr015 [pii]
AID - 10.1093/jmp/jhr015 [doi]
PST - ppublish
SO  - J Med Philos. 2011 Jun;36(3):261-73. doi: 10.1093/jmp/jhr015. Epub 2011 May 19.


PMID- 21596724
OWN - NLM
STAT- MEDLINE
DCOM- 20121012
LR  - 20211020
IS  - 1468-4373 (Electronic)
IS  - 0022-5045 (Linking)
VI  - 67
IP  - 3
DP  - 2012 Jul
TI  - War neuroses and Arthur Hurst: a pioneering medical film about the treatment of
      psychiatric battle casualties.
PG  - 345-73
LID - 10.1093/jhmas/jrr015 [doi]
AB  - From 1917 to 1918, Major Arthur Hurst filmed shell-shocked patients home from the
      war in France. Funded by the Medical Research Committee, and using Pathe
      cameramen, he recorded soldiers who suffered from intractable movement disorders 
      as they underwent treatment at the Royal Victoria Hospital in Netley and
      undertook programs of occupational therapy at Seale Hayne in Devon. As one of the
      earliest UK medical films, Hurst's efforts may have drawn inspiration from the
      official documentary of the Battle of the Somme and films made in 1916 by French 
      Army neurologists. Although initially motivated to make use of a novel medium to 
      illustrate lectures, Hurst was alert to the wider appeal of the motion picture
      and saw an opportunity to position himself in the postwar medical hierarchy. Some
      "before treatment" shots were reenacted for the camera. Hurst, like some other
      shell shock doctors, openly used deception as a therapeutic measure. On the basis
      that the ends justified the means, they defended this procedure as ethical.
      Clinicians also took advantage of changes in military regulations to address
      functional symptoms. Claims made of "cures" in the film and associated
      publications by Hurst were challenged by other doctors treating shell shock. The 
      absence of follow-up data and evidence from war pension files suggested that
      Hurst may have overstated the effectiveness of his methods. Nevertheless, the
      message conveyed in the film that chronic cases could be treated in a single
      session had a powerful resonance for ambitious or charismatic doctors and was
      revived in World War II.
FAU - Jones, Edgar
AU  - Jones E
AD  - King's College London, Institute of Psychiatry, London, UK.
      edgar.jones@iop.kcl.ac.uk
LA  - eng
GR  - 086071/Wellcome Trust/United Kingdom
PT  - Biography
PT  - Historical Article
PT  - Journal Article
DEP - 20110519
PL  - England
TA  - J Hist Med Allied Sci
JT  - Journal of the history of medicine and allied sciences
JID - 0413415
SB  - IM
MH  - Combat Disorders/*history/*therapy
MH  - France
MH  - History, 20th Century
MH  - Humans
MH  - Male
MH  - Military Personnel/*history/psychology
MH  - Motion Pictures/*history
MH  - United Kingdom
MH  - World War I
PS  - Hurst A
FPS - Hurst, Arthur
PMC - PMC5137781
MID - EMS70502
EDAT- 2011/05/21 06:00
MHDA- 2012/10/13 06:00
CRDT- 2011/05/21 06:00
PHST- 2011/05/21 06:00 [entrez]
PHST- 2011/05/21 06:00 [pubmed]
PHST- 2012/10/13 06:00 [medline]
AID - jrr015 [pii]
AID - 10.1093/jhmas/jrr015 [doi]
PST - ppublish
SO  - J Hist Med Allied Sci. 2012 Jul;67(3):345-73. doi: 10.1093/jhmas/jrr015. Epub
      2011 May 19.


PMID- 21596714
OWN - NLM
STAT- MEDLINE
DCOM- 20110831
LR  - 20120910
IS  - 1471-8391 (Electronic)
IS  - 0007-1420 (Linking)
VI  - 98
DP  - 2011
TI  - Guidance for withdrawal and withholding of intensive care as part of neonatal
      end-of-life care.
PG  - 99-113
LID - 10.1093/bmb/ldr016 [doi]
AB  - INTRODUCTION: Advances in foetal medicine and neonatology have enabled increased 
      antenatal diagnosis of life-limiting conditions and improved preterm survival,
      escalating the debate surrounding the ethics of neonatal end-of-life care and
      withholding or withdrawing intensive care. SOURCES OF DATA: Literature search of 
      MEDLINE and the Cochrane library databases using the search terms [neonatal
      palliative care] AND [neonatal AND withdrawal of intensive care and treatment].
      Review of consensus statements and guidelines. AREAS OF AGREEMENT: UK practice is
      aided by Grade 3-4 evidence, consensus statements and practice frameworks. There 
      is limited systematic evidence. AREAS OF CONTROVERSY: We illustrate UK practice
      with clinical cases and describe worldwide variations. GROWING POINTS: Neonatal
      end-of-life care incorporating withholding and withdrawing intensive care is not 
      uncommon. The child's 'best interests' take precedent and clinical guidance has
      been published to support the joint decision-making partnership of clinicians and
      families. Withholding and withdrawing intensive care should be part of an overall
      end-of-life care plan incorporating the principles and standards of palliative
      care. AREAS TIMELY FOR DEVELOPING RESEARCH: Further guidance on standards and
      staff training with regard to communicating and delivering neonatal end-of-life
      care is required to ensure consistent practice of staff and choices for families.
      The recommended establishment of neonatal outcome databases should aid UK preterm
      decision-making (NHS and Department of Health Neonatal Taskforce, Toolkit for
      high-quality neonatal services, London, Department of Health 2009).
FAU - Warrick, Catherine
AU  - Warrick C
AD  - Neonatal Unit, Northwick Park Hospital, North West London Hospitals NHS Trust,
      Harrow, UK.
FAU - Perera, Leonie
AU  - Perera L
FAU - Murdoch, Edile
AU  - Murdoch E
FAU - Nicholl, Richard M
AU  - Nicholl RM
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110519
PL  - England
TA  - Br Med Bull
JT  - British medical bulletin
JID - 0376542
SB  - IM
MH  - Bereavement
MH  - Evidence-Based Medicine
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Intensive Care, Neonatal/*standards
MH  - Palliative Care/standards
MH  - Practice Guidelines as Topic
MH  - Refusal to Treat
MH  - Terminal Care/*standards
MH  - Withholding Treatment/*standards
EDAT- 2011/05/21 06:00
MHDA- 2011/09/01 06:00
CRDT- 2011/05/21 06:00
PHST- 2011/05/21 06:00 [entrez]
PHST- 2011/05/21 06:00 [pubmed]
PHST- 2011/09/01 06:00 [medline]
AID - ldr016 [pii]
AID - 10.1093/bmb/ldr016 [doi]
PST - ppublish
SO  - Br Med Bull. 2011;98:99-113. doi: 10.1093/bmb/ldr016. Epub 2011 May 19.


PMID- 21596712
OWN - NLM
STAT- MEDLINE
DCOM- 20110831
LR  - 20120910
IS  - 1471-8391 (Electronic)
IS  - 0007-1420 (Linking)
VI  - 98
DP  - 2011
TI  - Non-medical sex-selective abortion in China: ethical and public policy issues in 
      the context of 40 million missing females.
PG  - 7-20
LID - 10.1093/bmb/ldr015 [doi]
AB  - INTRODUCTION: The rapidly growing imbalance of the sex ratio at birth (SRB) in
      China since the late 1980s demonstrates that, despite an extensive official
      prohibition, sex-selective abortion has been widely practised there in the past
      two or three decades. Given the reality of 30-40 million missing females, China
      has a more challenging set of ethical and social policy issues to be addressed
      regarding sex-selective abortion than is the case in Western and many other
      countries. SOURCES OF DATA: This article is based on a search and review of
      Chinese and English-language literature, including several very recent books in
      Chinese on the imbalance of the sex ratio at birth in China. It also draws on
      first-hand information gathered from the author's extensive fieldwork on Chinese 
      views and experiences of abortion. AREAS OF AGREEMENT: The current female deficit
      is a real and serious problem in China-not a 'false alarm' as earlier alleged. It
      is a direct consequence of the widespread practice of sex-selective abortion and 
      is chiefly caused by the strong socio-cultural preference for sons in China.
      Chinese academics-demographers and medical ethicists-in general agree with the
      official position that sex-selective abortion is morally wrong and should be
      legally prohibited. AREAS OF CONTROVERSY: Some critical voices, mainly in the
      English-language literature, have asked whether coercive state intervention in
      this area is ethically justifiable. Another controversial question is whether and
      to what degree China's ambitious and rigorous population control programme,
      widely known as the 'one child' policy, is a contributing factor to the
      phenomenon of millions of missing females. AREAS TIMELY FOR DEVELOPING RESEARCH: 
      Much further research on the ethical and social policy issues surrounding
      sex-selective abortion in the Chinese context needs to be done. Systematic
      quantitative and in-depth qualitative sociological investigations into Chinese
      people's attitudes toward the subject, and the role of medical professionals, are
      long overdue.
FAU - Nie, Jing-Bao
AU  - Nie JB
AD  - Bioethics Centre, Division of Health Science, University of Otago, Dunedin, New
      Zealand. jing-bao.nie@otago.ac.nz
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110519
PL  - England
TA  - Br Med Bull
JT  - British medical bulletin
JID - 0376542
SB  - IM
MH  - Abortion, Eugenic/ethics
MH  - Abortion, Induced/*ethics
MH  - China
MH  - Ethics, Medical
MH  - Female
MH  - Humans
MH  - Male
MH  - Pregnancy
MH  - Public Policy
MH  - Sex Preselection/*ethics/methods
MH  - Sex Ratio
EDAT- 2011/05/21 06:00
MHDA- 2011/09/01 06:00
CRDT- 2011/05/21 06:00
PHST- 2011/05/21 06:00 [entrez]
PHST- 2011/05/21 06:00 [pubmed]
PHST- 2011/09/01 06:00 [medline]
AID - ldr015 [pii]
AID - 10.1093/bmb/ldr015 [doi]
PST - ppublish
SO  - Br Med Bull. 2011;98:7-20. doi: 10.1093/bmb/ldr015. Epub 2011 May 19.


PMID- 21596586
OWN - NLM
STAT- MEDLINE
DCOM- 20120224
LR  - 20111021
IS  - 1090-2376 (Electronic)
IS  - 1053-8100 (Linking)
VI  - 20
IP  - 4
DP  - 2011 Dec
TI  - Persistent bias in expert judgments about free will and moral responsibility: a
      test of the expertise defense.
PG  - 1722-31
LID - 10.1016/j.concog.2011.04.007 [doi]
AB  - Many philosophers appeal to intuitions to support some philosophical views.
      However, there is reason to be concerned about this practice as scientific
      evidence has documented systematic bias in philosophically relevant intuitions as
      a function of seemingly irrelevant features (e.g., personality). One popular
      defense used to insulate philosophers from these concerns holds that
      philosophical expertise eliminates the influence of these extraneous factors.
      Here, we test this assumption. We present data suggesting that verifiable
      philosophical expertise in the free will debate-as measured by a reliable and
      validated test of expert knowledge-does not eliminate the influence of one
      important extraneous feature (i.e., the heritable personality trait extraversion)
      on judgments concerning freedom and moral responsibility. These results suggest
      that, in at least some important cases, the expertise defense fails. Implications
      for the practice of philosophy, experimental philosophy, and applied ethics are
      discussed.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Schulz, Eric
AU  - Schulz E
AD  - Center for Adaptive Behavior and Cognition, Max Planck Institute for Human
      Development, Germany.
FAU - Cokely, Edward T
AU  - Cokely ET
FAU - Feltz, Adam
AU  - Feltz A
LA  - eng
PT  - Journal Article
DEP - 20110518
PL  - United States
TA  - Conscious Cogn
JT  - Consciousness and cognition
JID - 9303140
SB  - IM
MH  - *Expert Testimony
MH  - Humans
MH  - Intuition
MH  - *Judgment
MH  - *Moral Obligations
MH  - *Observer Variation
MH  - *Personal Autonomy
MH  - Personality
MH  - Philosophy
EDAT- 2011/05/21 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/05/21 06:00
PHST- 2010/08/02 00:00 [received]
PHST- 2011/04/05 00:00 [revised]
PHST- 2011/04/10 00:00 [accepted]
PHST- 2011/05/21 06:00 [entrez]
PHST- 2011/05/21 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - S1053-8100(11)00123-1 [pii]
AID - 10.1016/j.concog.2011.04.007 [doi]
PST - ppublish
SO  - Conscious Cogn. 2011 Dec;20(4):1722-31. doi: 10.1016/j.concog.2011.04.007. Epub
      2011 May 18.


PMID- 21596242
OWN - NLM
STAT- MEDLINE
DCOM- 20110722
LR  - 20130520
IS  - 1873-4502 (Electronic)
IS  - 0886-3350 (Linking)
VI  - 37
IP  - 6
DP  - 2011 Jun
TI  - Sheep practice eye for ophthalmic surgery training in skills laboratory.
PG  - 987-91
LID - 10.1016/j.jcrs.2011.03.030 [doi]
AB  - UNLABELLED: Pig eyes are not available for surgical practice in the Middle East
      and Central Asia. We reviewed the literature to select an alternative animal
      practice eye based on biometry, availability, expense, and the ethical issue of
      animal sacrifice. Twenty enucleated sheep eyes were studied with an
      ultrasonography immersion technique, and a variety of techniques for globe
      harvesting were tested and compared. The sheep eye was judged to be the best
      practical choice for ophthalmic surgery practice and the "bone shattering"
      exenteration maneuver, the most efficient harvesting method. Several anterior
      segment procedures were performed in the sheep eyes. Introduction of this sheep
      model would be instrumental in the development of ophthalmology skills
      laboratories and surgical training in Middle Eastern and Central Asian regions.
      FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any
      material or method mentioned.
CI  - Copyright (c) 2011 ASCRS and ESCRS. Published by Elsevier Inc. All rights
      reserved.
FAU - Mohammadi, S Farzad
AU  - Mohammadi SF
AD  - Eye Research Center, Farabi Eye Hospital, Students' Scientific Research Center,
      Tehran University of Medical Sciences, Tehran, Iran.
FAU - Mazouri, Arash
AU  - Mazouri A
FAU - Jabbarvand, Mahmoud
AU  - Jabbarvand M
FAU - Rahman-A, Nazanin
AU  - Rahman-A N
FAU - Mohammadi, Aeen
AU  - Mohammadi A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Cataract Refract Surg
JT  - Journal of cataract and refractive surgery
JID - 8604171
SB  - IM
CIN - J Cataract Refract Surg. 2011 Oct;37(10):1916-7; author reply 1917-8. PMID:
      21930061
MH  - Animals
MH  - *Clinical Competence
MH  - *Clinical Laboratory Techniques
MH  - Eye Enucleation
MH  - Models, Educational
MH  - Ophthalmologic Surgical Procedures/*education
MH  - Ophthalmology/*education
MH  - Sheep
MH  - Tissue and Organ Harvesting
EDAT- 2011/05/21 06:00
MHDA- 2011/07/23 06:00
CRDT- 2011/05/21 06:00
PHST- 2010/12/27 00:00 [received]
PHST- 2011/01/29 00:00 [revised]
PHST- 2011/02/03 00:00 [accepted]
PHST- 2011/05/21 06:00 [entrez]
PHST- 2011/05/21 06:00 [pubmed]
PHST- 2011/07/23 06:00 [medline]
AID - S0886-3350(11)00449-4 [pii]
AID - 10.1016/j.jcrs.2011.03.030 [doi]
PST - ppublish
SO  - J Cataract Refract Surg. 2011 Jun;37(6):987-91. doi: 10.1016/j.jcrs.2011.03.030.


PMID- 21596192
OWN - NLM
STAT- MEDLINE
DCOM- 20111103
LR  - 20140205
IS  - 1806-907X (Electronic)
IS  - 0034-7094 (Linking)
VI  - 61
IP  - 3
DP  - 2011 May-Jun
TI  - [Non-invasive monitoring based on bioreactance reveals significant hemodynamic
      instability during elective cesarean delivery under spinal anesthesia].
PG  - 320-5
LID - 10.1016/S0034-7094(11)70038-1 [doi]
AB  - BACKGROUND AND OBJECTIVES: Blood pressure monitoring offers a limited
      understanding of the hemodynamic consequences of spinal anesthesia for cesarean
      delivery. The purpose of this study was to assess, with the aid of a non-invasive
      cardiac output monitor based on bioreactance, the hemodynamic changes during
      elective cesarean delivery under spinal anesthesia in which intermittent boluses 
      of phenylephrine were used to prevent and treat hypotension. METHODS: This
      observational study was conducted with the Research Ethics Board approval, and
      all participants provided written informed consent. Healthy patients undergoing
      elective cesarean delivery under spinal anesthesia were enrolled. Intermittent
      boluses of phenylephrine were administered in an attempt to maintain systolic
      blood pressure at baseline levels, and patients were assessed with a non-invasive
      cardiac output monitor based on bioreactance. Hemodynamic data was collected
      continuously at baseline, and during the postspinal and postdelivery periods.
      Data was analyzed using a mixed model ANOVA, and a p < 0.05 was considered
      significant. RESULTS: Systolic blood pressure was maintained within 79.2 +/- 14.2
      and 105.8 +/- 10.0 percent of baseline during the postspinal period, and 78.4 +/-
      11.3 and 100.9 +/- 10.7 percent of baseline in the postdelivery period (mean +/- 
      SD) There were significant fluctuations in systolic blood pressure, heart rate,
      and cardiac output during the postspinal period, and significant fluctuations in 
      systolic blood pressure and cardiac output in the postdelivery period.
      CONCLUSIONS: A new non-invasive monitor based on bioreactance reveals significant
      hemodynamic fluctuations during cesarean delivery under spinal anesthesia,
      despite attempts to maintain blood pressure at baseline levels with intermittent 
      boluses of phenylephrine.
CI  - 2011 Elsevier Editora Ltda. All rights reserved.
FAU - Doherty, Anne
AU  - Doherty A
AD  - Department of Anesthesia and Pain Management, Mount Sinai Hospital, University of
      Toronto.
FAU - Ohashi, Yayoi
AU  - Ohashi Y
FAU - Downey, Kristi
AU  - Downey K
FAU - Carvalho, Jose C A
AU  - Carvalho JC
LA  - mul
PT  - English Abstract
PT  - Journal Article
TT  - Monitorizacion no invasiva con base en la biorreactanciarevela inestabilidad
      hemodinamica significativa durante lacesarea por elegibilidad bajo
      raquianestesia.
PL  - Brazil
TA  - Rev Bras Anestesiol
JT  - Revista brasileira de anestesiologia
JID - 0401316
SB  - IM
MH  - *Anesthesia, Obstetrical
MH  - *Anesthesia, Spinal
MH  - Cesarean Section
MH  - Female
MH  - *Hemodynamics
MH  - Humans
MH  - Monitoring, Intraoperative/*methods
MH  - Pregnancy
EDAT- 2011/05/21 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/05/21 06:00
PHST- 2010/11/30 00:00 [received]
PHST- 2010/12/07 00:00 [accepted]
PHST- 2011/05/21 06:00 [entrez]
PHST- 2011/05/21 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
AID - S0034-7094(11)70038-1 [pii]
AID - 10.1016/S0034-7094(11)70038-1 [doi]
PST - ppublish
SO  - Rev Bras Anestesiol. 2011 May-Jun;61(3):320-5. doi:
      10.1016/S0034-7094(11)70038-1.


PMID- 21596187
OWN - NLM
STAT- MEDLINE
DCOM- 20111103
LR  - 20140205
IS  - 1806-907X (Electronic)
IS  - 0034-7094 (Linking)
VI  - 61
IP  - 3
DP  - 2011 May-Jun
TI  - [Evaluation of cytokine levels and pulmonary function in patients undergoing
      coronary artery bypass graft].
PG  - 275-85
LID - 10.1016/S0034-7094(11)70033-2 [doi]
AB  - BACKGROUND AND OBJECTIVES: Systemic inflammatory response syndrome is commonly
      observed in coronary artery bypass grafts (CABG) with cardiopulmonary bypass
      (CB). The objective of this study was to evaluate the systemic and pulmonary
      levels of cytokines and their correlation with lung function in patients
      undergoing myocardial revascularization (MR) with CB. METHODS: This study was
      approved by the Institutional Ethics Committee, and 13 patients undergoing MR
      with CB were evaluated. After anesthetic induction and at the end of CB, plasma
      and bronchoalveolar lavage levels of IL-1beta, IL-6, IL-8, IL-10, and TNF-alpha
      were determined. The duration of CB and surgery, PaO(2)/FiO(2) ratio,
      alveolar-arterial oxygen gradient (A-a gradient), shunt, and lung compliance were
      evaluated. Results were submitted to analysis of variance for repeated
      measurements (*p < 0.05) and Spearman's correlation coefficient. RESULTS: We
      observed increased levels of cytokines in plasma and bronchoalveolar lavage after
      CB and a direct relationship between the increase in IL-1beta and decrease in
      lung compliance (p = 0.0439), as well as the inverse relationship between the
      increase in IL-10 and a decrease in compliance (p = 0.0325). The increase in IL-6
      was directly related to the duration of CB (p = 0.012), while the increase in
      IL-8 was directly related to the duration of surgery (p < 0.0001). Levels of
      interleukin-1beta, IL-8, and TNF-alpha in bronchoalveolar lavage were higher than
      in plasma. CONCLUSIONS: There is an increase in cytokine levels in plasma and
      bronchoalveolar lavage after CB, as well as a correlation between increased
      cytokine levels and CB duration and surgery and changes in lung compliance.
CI  - 2011 Elsevier Editora Ltda. All rights reserved.
FAU - Machado, Luciano Brandao
AU  - Machado LB
AD  - Physician of the Servico de Anestesiologia UNIANEST, Bauru-SP.
FAU - Negri, Elnara Marcia
AU  - Negri EM
FAU - Bonafe, Wanderley Wesley
AU  - Bonafe WW
FAU - Santos, Luciana Moraes
AU  - Santos LM
FAU - Sa Malbouisson, Luis Marcelo
AU  - Sa Malbouisson LM
FAU - Carmona, Maria Jose Carvalho
AU  - Carmona MJ
LA  - mul
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
TT  - Evaluacion de los niveles de citocinas y de la funcionpulmonar de pacientes
      sometidos a la cirugia cardiaca concirculacion extracorporea.
PL  - Brazil
TA  - Rev Bras Anestesiol
JT  - Revista brasileira de anestesiologia
JID - 0401316
RN  - 0 (Cytokines)
SB  - IM
CIN - Rev Bras Anestesiol. 2012 Jan-Feb;62(1):137-8. PMID: 22248775
CIN - Rev Bras Anestesiol. 2012 Jul;62(4):596-8. PMID: 22793976
MH  - Aged
MH  - Bronchoalveolar Lavage Fluid/chemistry
MH  - *Coronary Artery Bypass
MH  - Cytokines/*analysis/blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Postoperative Care
MH  - Preoperative Care
MH  - Respiratory Function Tests
EDAT- 2011/05/21 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/05/21 06:00
PHST- 2010/07/21 00:00 [received]
PHST- 2010/12/07 00:00 [accepted]
PHST- 2011/05/21 06:00 [entrez]
PHST- 2011/05/21 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
AID - S0034-7094(11)70033-2 [pii]
AID - 10.1016/S0034-7094(11)70033-2 [doi]
PST - ppublish
SO  - Rev Bras Anestesiol. 2011 May-Jun;61(3):275-85. doi:
      10.1016/S0034-7094(11)70033-2.


PMID- 21596003
OWN - NLM
STAT- MEDLINE
DCOM- 20150521
LR  - 20220410
IS  - 1757-6512 (Electronic)
IS  - 1757-6512 (Linking)
VI  - 2
IP  - 3
DP  - 2011 May 19
TI  - Amnion-derived stem cells: in quest of clinical applications.
PG  - 25
LID - 10.1186/scrt66 [doi]
AB  - In the promising field of regenerative medicine, human perinatal stem cells are
      of great interest as potential stem cells with clinical applications. Perinatal
      stem cells could be isolated from normally discarded human placentae, which are
      an ideal cell source in terms of availability, the fewer number of ethical
      concerns, less DNA damage, and so on. Numerous studies have demonstrated that
      some of the placenta-derived cells possess stem cell characteristics like
      pluripotent differentiation ability, particularly in amniotic epithelial (AE)
      cells. Term human amniotic epithelium contains a relatively large number of stem 
      cell marker-positive cells as an adult stem cell source. In this review, we
      introduce a model theory of why so many AE cells possess stem cell
      characteristics. We also describe previous work concerning the therapeutic
      applications and discuss the pluripotency of the AE cells and potential pitfalls 
      for amnion-derived stem cell research.
FAU - Miki, Toshio
AU  - Miki T
AD  - Department of Developmental Biology, University of Pittsburgh, 530 45th Street,
      8112 Rangos Research Center, Pittsburgh, PA 15201, USA. toshiomi@usc.edu
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110519
PL  - England
TA  - Stem Cell Res Ther
JT  - Stem cell research & therapy
JID - 101527581
RN  - 0 (Antigens, Differentiation)
SB  - IM
MH  - Amnion/*cytology
MH  - Animals
MH  - Antigens, Differentiation/analysis
MH  - Cell Differentiation
MH  - Cell Lineage
MH  - Cell Separation/methods
MH  - Cells, Cultured/cytology/drug effects
MH  - Clinical Trials as Topic
MH  - Epithelial Cells/cytology
MH  - Female
MH  - Germ Layers/cytology
MH  - Humans
MH  - Immune Tolerance
MH  - Immunologic Deficiency Syndromes
MH  - Immunomodulation
MH  - Lysosomal Storage Diseases/surgery
MH  - Mice
MH  - Mice, Mutant Strains
MH  - Placenta/cytology
MH  - Pluripotent Stem Cells/*cytology
MH  - Pregnancy
MH  - Stem Cell Transplantation/adverse effects/ethics/*methods
MH  - Transplantation Immunology
MH  - Transplantation, Heterologous
MH  - Treatment Outcome
PMC - PMC3152995
GN  - NLM: Original DateCompleted: 20111110
EDAT- 2011/05/21 06:00
MHDA- 2011/05/21 06:01
CRDT- 2011/05/21 06:00
PHST- 2011/05/21 06:00 [entrez]
PHST- 2011/05/21 06:00 [pubmed]
PHST- 2011/05/21 06:01 [medline]
AID - scrt66 [pii]
AID - 10.1186/scrt66 [doi]
PST - epublish
SO  - Stem Cell Res Ther. 2011 May 19;2(3):25. doi: 10.1186/scrt66.


PMID- 21595413
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20170214
IS  - 0025-8024 (Print)
IS  - 0025-8024 (Linking)
VI  - 51
IP  - 1
DP  - 2011 Jan
TI  - Proceedings of the Sixth Northern Region Paediatric Colloquium.
PG  - 1-4
AB  - It is apparent that the practice of medicine in today's society can often raise
      difficult legal and ethical dilemmas. With this in mind, senior figures from the 
      medical, legal and theological professions have met on a biennial basis in order 
      to discuss anonymised case material of such a nature. This provides a valuable
      forum in which to discuss such dilemmas, enabling the sharing of knowledge and
      experience from which we all can learn. To this end, we report the proceedings of
      the 'Sixth Northern Region Paediatric Colloquium', which are now the third set of
      proceedings to be published.
FAU - Abbott, Mandy
AU  - Abbott M
AD  - CAMHS, 1st Floor Benton House 136, Sandyford Road, Newcastle upon Tyne NE2 1QE,
      UK. mandyabbott@gmail.com
FAU - Reid, Corrine
AU  - Reid C
LA  - eng
PT  - Journal Article
PL  - England
TA  - Med Sci Law
JT  - Medicine, science, and the law
JID - 0400721
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child Welfare/*legislation & jurisprudence
MH  - Circumcision, Male/legislation & jurisprudence
MH  - Congresses as Topic
MH  - Female
MH  - Humans
MH  - Male
MH  - Mental Competency/*legislation & jurisprudence
MH  - Pregnancy
MH  - Registries
MH  - Religion
MH  - Sex Offenses/*legislation & jurisprudence
MH  - Young Adult
EDAT- 2011/05/21 06:00
MHDA- 2011/06/29 06:00
CRDT- 2011/05/21 06:00
PHST- 2011/05/21 06:00 [entrez]
PHST- 2011/05/21 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
AID - 10.1258/msl.2010.010044 [doi]
PST - ppublish
SO  - Med Sci Law. 2011 Jan;51(1):1-4. doi: 10.1258/msl.2010.010044.


PMID- 21595359
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20110520
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 22
IP  - 1
DP  - 2011 Spring
TI  - Ethical issues related to direct nursing care time, compared to time spent
      charting in intensive care units.
PG  - 94
FAU - Roffey, Peter
AU  - Roffey P
FAU - Thangathurai, Duraiyah
AU  - Thangathurai D
LA  - eng
PT  - Letter
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
MH  - Humans
MH  - *Intensive Care Units/ethics/standards
MH  - Nurse-Patient Relations/ethics
MH  - Nursing Care/*ethics/standards/trends
MH  - *Nursing Records/statistics & numerical data
MH  - *Time Factors
EDAT- 2011/05/21 06:00
MHDA- 2011/06/03 06:00
CRDT- 2011/05/21 06:00
PHST- 2011/05/21 06:00 [entrez]
PHST- 2011/05/21 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2011 Spring;22(1):94.


PMID- 21595358
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20110520
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 22
IP  - 1
DP  - 2011 Spring
TI  - Legal briefing: Healthcare ethics committees.
PG  - 74-93
AB  - This issue's "Legal Briefing" column covers recent legal developments involving
      institutional healthcare ethics committees. This topic has been the subject of
      recent articles in JCE. Healthcare ethics committees have also recently been the 
      subject of significant public policy attention. Disturbingly, Bobby Schindler and
      others have described ethics committees as "death panels." But most of the recent
      attention has been positive. Over the past several months, legislatures and
      courts have expanded the use of ethics committees and clarified their roles
      concerning both end-of-life treatment and other issues. These developments are
      usefully grouped into the following eight categories: 1. Existence and
      availability. 2. Membership and composition. 3. Operating procedures. 4. Advisory
      roles. 5. Decision-making and gate-keeping roles. 6. Confidentiality. 7.
      Immunity. 8. Litigation and court cases.
FAU - Pope, Thaddeus Mason
AU  - Pope TM
AD  - Health Law Institute at Widener University School of Law, Wilmington, Deleware,
      USA. tmpope@widener.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
MH  - Alberta
MH  - Confidentiality/ethics
MH  - Decision Making/ethics
MH  - *Ethics Committees, Clinical/ethics/legislation & jurisprudence/organization &
      administration
MH  - Humans
MH  - Israel
MH  - Jurisprudence
MH  - Norway
MH  - *Public Policy/legislation & jurisprudence/trends
MH  - Singapore
MH  - Spain
MH  - Taiwan
MH  - United States
EDAT- 2011/05/21 06:00
MHDA- 2011/06/03 06:00
CRDT- 2011/05/21 06:00
PHST- 2011/05/21 06:00 [entrez]
PHST- 2011/05/21 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2011 Spring;22(1):74-93.


PMID- 21595355
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20110520
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 22
IP  - 1
DP  - 2011 Spring
TI  - Ethical care for infants with conditions not curable with intensive care.
PG  - 54-60
AB  - Offering intensive care to neonates who have conditions that carry extremely poor
      prognoses is a source of great contention amongst neonatologists. The concept of 
      best interests is commonly used as a rationale for refusing such care, despite
      the fact that parents of these infants often have a different view of what best
      interests means. This article takes up the question of what best interests should
      incorporate for infants with lethal conditions not curable with intensive care,
      and how and who should decide which treatment options should be implemented.
      Based on our recommendation that parents be apprised of the basis upon which
      physicians are evaluating treatment options, we offer a framework that allows all
      relevant parties to approach the issue of what is appropriate treatment from a
      similar place. We maintain that this approach will increase transparency,
      dialogue, understanding, and trust, which, in turn, may result in greater
      consensus.
FAU - Everett, Bethan J
AU  - Everett BJ
AD  - Faculty of Medicine, Department of Physical Therapy, University of British
      Columbia. bjeverett@shaw.ca
FAU - Albersheim, Susan G
AU  - Albersheim SG
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
MH  - *Abnormalities, Multiple/therapy
MH  - Choice Behavior/ethics
MH  - Chromosomes, Human, Pair 18
MH  - Communication
MH  - Consensus
MH  - Decision Making/*ethics
MH  - Ethics, Medical
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Intensive Care, Neonatal/*ethics
MH  - Negotiating
MH  - *Parents
MH  - Physicians/*ethics
MH  - Problem Solving/*ethics
MH  - Time Factors
MH  - Trisomy
MH  - Uncertainty
EDAT- 2011/05/21 06:00
MHDA- 2011/06/03 06:00
CRDT- 2011/05/21 06:00
PHST- 2011/05/21 06:00 [entrez]
PHST- 2011/05/21 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2011 Spring;22(1):54-60.


PMID- 21595354
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20110520
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 22
IP  - 1
DP  - 2011 Spring
TI  - Attending to social vulnerability when rationing pandemic resources.
PG  - 42-53
AB  - Pandemic plans are increasingly attending to groups experiencing health
      disparities and other social vulnerabilities. Although some pandemic guidance is 
      silent on the issue, guidance that attends to socially vulnerable groups ranges
      widely, some procedural (often calling for public engagement), and some
      substantive. Public engagement objectives vary from merely educational to seeking
      reflective input into the ethical commitments that should guide pandemic planning
      and response. Some plans that concern rationing during a severe pandemic
      recommend ways to protect socially vulnerable groups without prioritizing access 
      to scarce resources based on social vulnerability per se. The Minnesota Pandemic 
      Ethics Project (MPEP), a public engagement project on rationing scarce health
      resources during a severe influenza pandemic, agrees and recommends an integrated
      set of ways to attend to the needs of socially vulnerable people and avoid
      exacerbation of health disparities during a severe influenza pandemic. Among
      other things, MPEP recommends: 1. Engaging socially vulnerable populations to
      clarify unique needs and effective strategies; 2. Engaging socially vulnerable
      populations to elicit ethical values and perspectives on rationing; 3. Rejecting 
      rationing based on race, socioeconomic class, citizenship, quality of life,
      length of life-extension and first-come, first-served; 4. Prioritizing those in
      the general population for access to resources based on combinations of risk (of 
      death or severe complications from influenza, exposure to influenza, transmitting
      influenza to vulnerable groups) and the likelihood of responding well to the
      resource in question. 5. Protecting critical infrastructures on which vulnerable 
      populations and the general public rely; 6. Identifying and removing access
      barriers during pandemic planning and response; and 7. Collecting and promptly
      analyzing data during the pandemic to identify groups at disproportionate risk of
      influenza-related mortality and serious morbidity and to optimize the
      distribution of resources.
FAU - Vawter, Dorothy E
AU  - Vawter DE
AD  - Minnesota Center for Health Care Ethics, St. Paul, Minnesota, USA.
      vawter@mnhealthethics.org
FAU - Garrett, J Eline
AU  - Garrett JE
FAU - Gervais, Karen G
AU  - Gervais KG
FAU - Prehn, Angela Witt
AU  - Prehn AW
FAU - DeBruin, Debra A
AU  - DeBruin DA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
MH  - *Disasters
MH  - Health Care Rationing/*ethics
MH  - Health Services Needs and Demand
MH  - Healthcare Disparities/ethics
MH  - Humans
MH  - Influenza, Human/*epidemiology/mortality
MH  - Minnesota
MH  - Pandemics/*ethics
MH  - Prejudice
MH  - Program Evaluation
MH  - *Social Justice
MH  - *Vulnerable Populations
EDAT- 2011/05/21 06:00
MHDA- 2011/06/03 06:00
CRDT- 2011/05/21 06:00
PHST- 2011/05/21 06:00 [entrez]
PHST- 2011/05/21 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2011 Spring;22(1):42-53.


PMID- 21595353
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20110520
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 22
IP  - 1
DP  - 2011 Spring
TI  - Unaltered ethical standards for individual physicians in the face of drastically 
      reduced resources resulting from an improvised nuclear device event.
PG  - 33-41
AB  - When disaster disrupts healthcare and other systems, the ethical allocation of
      resources should follow principles of justice, defined as fairness, established
      for normal clinical practice. Standards of clinical practice may be altered
      during disaster, but ethical standards must remain centered on prioritizing the
      treatment of patients according to need and the effectiveness of treatment.
      Should resources become extremely limited, it is fair to restrict their use to
      patients who have the highest needs, provided that the intervention is effective.
      When resources become more available, patients with lower priority can be
      increasingly accommodated.
FAU - Caro, J Jaime
AU  - Caro JJ
AD  - Department of Epidemiology, Biostatistics and Occupational Health, Division of
      General Internal Medicine, McGill University, Montreal.
      Jaime.Caro@unitedbiosource.com
FAU - Coleman, C Norman
AU  - Coleman CN
FAU - Knebel, Ann
AU  - Knebel A
FAU - DeRenzo, Evan G
AU  - DeRenzo EG
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
MH  - Choice Behavior/ethics
MH  - Decision Making/*ethics
MH  - Health Care Rationing/*ethics
MH  - Health Resources/*supply & distribution
MH  - Humans
MH  - Physicians/*ethics/standards
MH  - *Radioactive Hazard Release
MH  - *Social Justice
MH  - Triage/*ethics
EDAT- 2011/05/21 06:00
MHDA- 2011/06/03 06:00
CRDT- 2011/05/21 06:00
PHST- 2011/05/21 06:00 [entrez]
PHST- 2011/05/21 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2011 Spring;22(1):33-41.


PMID- 21595352
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20140325
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 22
IP  - 1
DP  - 2011 Spring
TI  - Non-pharmaceutical interventions to limit the transmission of a pandemic virus:
      the need for complementary programs to address children's diverse needs.
PG  - 25-32
AB  - Non-pharmaceutical interventions, including social distancing, quarantine, and
      isolation, are a potentially attractive means to limit the transmission of a
      pandemic virus. Many of these interventions are directed at children given
      children's disproportionate role in amplifying epidemics. The ethics of
      non-pharmaceutical interventions can be analyzed using Nancy Kass' ethics
      framework for public health. Such an analysis highlights the limited data
      supporting these interventions' effectiveness. It also suggests the framework
      itself needs to be expanded to consider harms other than constraints on liberty
      and to consider affirmative programs to mitigate these broader harms.
FAU - Antommaria, Armand H Matheny
AU  - Antommaria AH
AD  - Division of Pediatric Inpatient Medicine, University of Utah School of Medicine, 
      Salt Lake City, USA. armand.antommaria@hsc.utah.edu
FAU - Thorell, Emily A
AU  - Thorell EA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Communicable Disease Control/*methods
MH  - Confidentiality/ethics
MH  - Freedom
MH  - Humans
MH  - Infection Control/methods
MH  - Pandemics/*ethics
MH  - Patient Isolation/*ethics
MH  - Pediatrics/*ethics
MH  - Personal Autonomy
MH  - Public Health/*ethics
MH  - Quarantine/*ethics
MH  - Social Justice/ethics
MH  - Virus Diseases/*prevention & control/transmission
EDAT- 2011/05/21 06:00
MHDA- 2011/06/03 06:00
CRDT- 2011/05/21 06:00
PHST- 2011/05/21 06:00 [entrez]
PHST- 2011/05/21 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2011 Spring;22(1):25-32.


PMID- 21595351
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20110520
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 22
IP  - 1
DP  - 2011 Spring
TI  - An ethical framework for the responsible management of pregnant patients in a
      medical disaster.
PG  - 20-4
AB  - The ethics of managing obstetric patients in medical disasters poses ethical
      challenges that are unique in comparison to other disaster patients, because the 
      medical needs of two patients--the pregnant patient and the fetal patient--must
      be considered. We provide an ethical framework for doing so. We base the
      framework on the justice-based prevention of exploitation of populations of
      patients, both obstetric and non-obstetric, in medical disasters. We use the
      concept of exploitation to identify a spectrum from ethically acceptable, to
      ethically challenging, to ethically unacceptable, management of obstetric
      patients in medical disasters. We also address the ethics of the care of
      obstetric and neonatal patients when the resources of a hospital are completely
      overwhelmed in a large-scale medical disaster.
FAU - Chervenak, Frank A
AU  - Chervenak FA
AD  - Department of Obstetrics and Gynecology at New York Presbyterian Hospital-Weill
      Cornell Medical College, New York City, USA.
FAU - McCullough, Laurence B
AU  - McCullough LB
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
MH  - Beneficence
MH  - Delivery, Obstetric/*ethics
MH  - *Disasters
MH  - Female
MH  - *Fetus
MH  - Health Care Rationing/*ethics
MH  - Health Services Needs and Demand/ethics
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Labor, Obstetric
MH  - Obstetrics/*ethics
MH  - Physician-Patient Relations/*ethics
MH  - Pregnancy
MH  - *Pregnant Women
MH  - Social Justice
MH  - *Triage
EDAT- 2011/05/21 06:00
MHDA- 2011/06/03 06:00
CRDT- 2011/05/21 06:00
PHST- 2011/05/21 06:00 [entrez]
PHST- 2011/05/21 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2011 Spring;22(1):20-4.


PMID- 21595350
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20110520
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 22
IP  - 1
DP  - 2011 Spring
TI  - Imagining the unthinkable, illuminating the present.
PG  - 17-9
AB  - During a catastrophe that disables the health system, ethically charged
      situations will undoubtedly emerge that will challenge patients, relatives,
      clinicians, and others involved in health delivery. This second of two special
      sections of The Journal of Clinical Ethics includes discussions of the
      implications of a system collapse on particularly vulnerable member of society,
      children, pregnant women, and those who are socio-economically, culturally, and
      linguistically disempowered. Additionally, it offers insights into the processes 
      used by committees to plan for catastrophic care.
FAU - Berger, Jeffrey T
AU  - Berger JT
AD  - S.U.NY Stony Brook School of Medicine, USA. jberger@winthrop.org
LA  - eng
PT  - Introductory Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
MH  - Child
MH  - Cultural Characteristics
MH  - *Disasters
MH  - Female
MH  - Health Care Rationing/*ethics
MH  - Humans
MH  - Intensive Care, Neonatal
MH  - Language
MH  - Pandemics/ethics
MH  - Pregnancy
MH  - Pregnant Women/psychology
MH  - Prognosis
MH  - Socioeconomic Factors
MH  - *Vulnerable Populations
EDAT- 2011/05/21 06:00
MHDA- 2011/06/03 06:00
CRDT- 2011/05/21 06:00
PHST- 2011/05/21 06:00 [entrez]
PHST- 2011/05/21 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2011 Spring;22(1):17-9.


PMID- 21595315
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20110519
IS  - 1660-9379 (Print)
IS  - 1660-9379 (Linking)
VI  - 7
IP  - 290
DP  - 2011 Apr 13
TI  - [Ethical miscellany].
PG  - 828-9
FAU - Nau, Jean-Yves
AU  - Nau JY
AD  - jeanyves.nau@gmail.com
LA  - fre
PT  - Journal Article
TT  - Miscellanees ethiques (1).
PL  - Switzerland
TA  - Rev Med Suisse
JT  - Revue medicale suisse
JID - 101219148
SB  - IM
MH  - *Bioethics
MH  - Europe
MH  - Humans
EDAT- 2011/05/21 06:00
MHDA- 2011/06/03 06:00
CRDT- 2011/05/21 06:00
PHST- 2011/05/21 06:00 [entrez]
PHST- 2011/05/21 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
PST - ppublish
SO  - Rev Med Suisse. 2011 Apr 13;7(290):828-9.


PMID- 21595115
STAT- Publisher
DA  - 20110520
ISBN- 9780309154000
ISBN- 0309154006
PB  - National Academies Press (US)
ED  - 8th
CTI - The National Academies Collection: Reports funded by National Institutes of
      Health
DP  - 2011
BTI - Guide for the Care and Use of Laboratory Animals
AB  - The purpose of the Guide for the Care and Use of Laboratory Animals (the Guide), 
      as expressed in the charge to the Committee for the Update of the Guide, is to
      assist institutions in caring for and using animals in ways judged to be
      scientifically, technically, and humanely appropriate. The Guide is also intended
      to assist investigators in fulfilling their obligation to plan and conduct animal
      experiments in accord with the highest scientific, humane, and ethical
      principles. Recommendations in the Guide are based on published data, scientific 
      principles, expert opinion, and experience with methods and practices that have
      proved to be consistent with both high-quality research and humane animal care
      and use. These recommendations should be used as a foundation for the development
      of a comprehensive animal care and use program, recognizing that the concept and 
      application of performance standards, in accordance with goals, outcomes, and
      considerations defined in the Guide, is essential to this process.
CI  - Copyright (c) 2011, National Academy of Sciences.
CN  - National Research Council (US) Committee for the Update of the Guide for the Care
      and Use of Laboratory Animals
LA  - eng
GR  - N01 OD042139/NIH HHS/United States
PT  - Review
PT  - Book
PL  - Washington (DC)
EDAT- 2011/05/20 06:00
MHDA- 2011/05/20 06:00
CDAT- 2011/05/20 06:00
AID - NBK54050 [bookaccession]
AID - 10.17226/12910 [doi]


PMID- 21595007
OWN - NLM
STAT- MEDLINE
DCOM- 20111205
LR  - 20211203
IS  - 1552-485X (Electronic)
IS  - 1552-4841 (Linking)
VI  - 156B
IP  - 5
DP  - 2011 Jul
TI  - Ethnic disparities in the perception of ethical risks from psychiatric genetic
      studies.
PG  - 569-80
LID - 10.1002/ajmg.b.31198 [doi]
AB  - To examine if ethnic differences in concerns about unfavorable consequences from 
      psychiatric genetic studies, existing between non-Hispanic Black and White
      populations, persist among participants in an actual genetic study of bipolar
      disorder. Historically, minority subjects have been less willing to participate
      in such studies. Participants in the US Bipolar Genome Study (BIGS) were assessed
      on six items of concerns in the Questionnaire on Genetic Risk (QGR). Each item
      had five response categories, ranging from "not at all" concerned to "very
      concerned." Responses from Black (N = 188) and White participants (N = 1,065)
      formed the base for this analysis. Concerns about unfavorable consequences of
      conducting psychiatric genetic studies were prevalent in the whole sample.
      Concern for medical insurance was most prevalent (63.4%), followed by job concern
      (58.8%) and stigma (57.4%). Racial discrimination was less prevalent (28.1%).
      Blacks endorsed significantly stronger concerns for all consequences except the
      medical insurance item (P < 0.008). The most significant ethnic disparity in
      concerns was for racial discrimination (P < 0.0001). Associations between levels 
      of concern and ethnicity remained significant after adjustments for other factors
      in multivariate models. Ethnic differences (Blacks vs. Whites) in perceived
      concerns about unfavorable consequences from participation persist among
      participants in an actual psychiatric genetic study. This suggests that other
      factors may play a more critical role in the decision not to participate. Future 
      studies should investigate more comprehensive sources of barriers to consenting
      for ongoing psychiatric genetic studies in representative samples, incorporating 
      assessments from non-participants as well as participants.
CI  - Copyright (c) 2011 Wiley-Liss, Inc.
FAU - Nwulia, E A
AU  - Nwulia EA
AD  - Howard University College of Medicine, Washington, District of Columbia, USA.
      enwulia@howard.edu
FAU - Hipolito, M M
AU  - Hipolito MM
FAU - Aamir, S
AU  - Aamir S
FAU - Lawson, W B
AU  - Lawson WB
FAU - Nurnberger, J I Jr
AU  - Nurnberger JI Jr
CN  - BiGS Consortium
LA  - eng
GR  - R01 MH059534/MH/NIMH NIH HHS/United States
GR  - R01 MH59545/MH/NIMH NIH HHS/United States
GR  - R01 MH59535/MH/NIMH NIH HHS/United States
GR  - R01 MH59553/MH/NIMH NIH HHS/United States
GR  - R01 MH60068/MH/NIMH NIH HHS/United States
GR  - R01MH059548/MH/NIMH NIH HHS/United States
GR  - R01 MH59567/MH/NIMH NIH HHS/United States
GR  - R01 MH042243/MH/NIMH NIH HHS/United States
GR  - R01 MH59533/MH/NIMH NIH HHS/United States
GR  - 1Z01MH002810-01/MH/NIMH NIH HHS/United States
GR  - K02 DA21237/DA/NIDA NIH HHS/United States
GR  - R01 MH059556/MH/NIMH NIH HHS/United States
GR  - ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
DEP - 20110518
PL  - United States
TA  - Am J Med Genet B Neuropsychiatr Genet
JT  - American journal of medical genetics. Part B, Neuropsychiatric genetics : the
      official publication of the International Society of Psychiatric Genetics
JID - 101235742
SB  - IM
MH  - Adult
MH  - African Americans/ethnology
MH  - Attitude/ethnology
MH  - Bipolar Disorder/ethnology/*genetics
MH  - Employment
MH  - Female
MH  - Health Services Accessibility/statistics & numerical data
MH  - Humans
MH  - Insurance, Health
MH  - Male
MH  - Middle Aged
MH  - Perception/ethics
MH  - Prejudice
MH  - Privacy
MH  - Public Opinion
MH  - Risk
MH  - Surveys and Questionnaires
MH  - Whites
EDAT- 2011/05/20 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/05/20 06:00
PHST- 2011/01/19 00:00 [received]
PHST- 2011/04/25 00:00 [accepted]
PHST- 2011/05/20 06:00 [entrez]
PHST- 2011/05/20 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1002/ajmg.b.31198 [doi]
PST - ppublish
SO  - Am J Med Genet B Neuropsychiatr Genet. 2011 Jul;156B(5):569-80. doi:
      10.1002/ajmg.b.31198. Epub 2011 May 18.


PMID- 21594612
OWN - NLM
STAT- MEDLINE
DCOM- 20111223
LR  - 20211020
IS  - 1437-1596 (Electronic)
IS  - 0937-9827 (Linking)
VI  - 125
IP  - 5
DP  - 2011 Sep
TI  - Bio-medicolegal scientific research in Europe. A country-based analysis.
PG  - 717-25
LID - 10.1007/s00414-011-0576-3 [doi]
AB  - The European mosaic of socio-cultural, economic and legal realities is reflected 
      in forensic and legal medicine, in which a great variety of operational modes of 
      forensic medical services, organisational systems, structures, functional
      competences and scientific research strategies can be observed. The present work 
      analyses the European bio-medicolegal scientific output of the last 5.5 years
      (exact time window, January 1, 2005-June 1, 2010), categorising papers by
      nationality of the corresponding author and forensic sub-discipline in question, 
      in order to identify the peculiarities of national sub-specialised competences
      and to build up international research projects. This country-based bibliometric 
      analysis, based on the number of articles and the impact factor produced by each 
      European country, also considering its economic profile (gross domestic product
      and per capita gross domestic product), highlights the prevailing productive role
      of Western and Southern Europe (Germany, Great Britain, Italy, Switzerland, Spain
      and France). Categorising scientific output by forensic sub-discipline and
      branch, significant in terms of impact factor are contributions from Germany
      (coming first in Pathology, Toxicology, Genetics, Anthropology and Biological
      Criminalistics), Great Britain (first in Clinical Forensic Medicine, Malpractice 
      and Invalidity-Social Insurance), Switzerland (first in Criminology), Italy
      (second in Toxicology, Anthropology and Invalidity-Social Insurance), The
      Netherlands (third in Clinical Forensic Medicine and Medical Law and Ethics),
      Spain (third in Genetics, Criminalistics and Invalidity-Social Insurance) and
      France (third in Toxicology and Malpractice). Interestingly, several countries
      with low gross domestic product, such as Poland, Turkey and other Eastern
      European nations, show notable scientific production in specific sub-disciplines 
      such as Pathology, Toxicology and Forensic Genetics, suggesting that fruitful
      international cooperation could be planned and be of interest to funding sources 
      within the European Community, also taking into account funds reserved for
      depressed areas undergoing development.
FAU - Viel, Guido
AU  - Viel G
AD  - Department of Environmental Medicine and Public Health, Institute of Legal
      Medicine, University-Hospital of Padova, Via Falloppio 50, Padua, Italy.
FAU - Boscolo-Berto, Rafael
AU  - Boscolo-Berto R
FAU - Cecchi, Rossana
AU  - Cecchi R
FAU - Bajanowski, Thomas
AU  - Bajanowski T
FAU - Vieira, Nuno Duarte
AU  - Vieira ND
FAU - Ferrara, Santo Davide
AU  - Ferrara SD
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110519
PL  - Germany
TA  - Int J Legal Med
JT  - International journal of legal medicine
JID - 9101456
SB  - IM
MH  - Bibliometrics
MH  - Biomedical Research/*statistics & numerical data
MH  - *Cross-Cultural Comparison
MH  - Europe
MH  - *European Union
MH  - Forensic Medicine/*statistics & numerical data
MH  - Humans
MH  - Journal Impact Factor
MH  - Periodicals as Topic/*statistics & numerical data
MH  - Publishing/*statistics & numerical data
EDAT- 2011/05/20 06:00
MHDA- 2011/12/24 06:00
CRDT- 2011/05/20 06:00
PHST- 2011/03/09 00:00 [received]
PHST- 2011/04/15 00:00 [accepted]
PHST- 2011/05/20 06:00 [entrez]
PHST- 2011/05/20 06:00 [pubmed]
PHST- 2011/12/24 06:00 [medline]
AID - 10.1007/s00414-011-0576-3 [doi]
PST - ppublish
SO  - Int J Legal Med. 2011 Sep;125(5):717-25. doi: 10.1007/s00414-011-0576-3. Epub
      2011 May 19.


PMID- 21593244
OWN - NLM
STAT- MEDLINE
DCOM- 20111212
LR  - 20211203
IS  - 1473-4265 (Electronic)
IS  - 1468-215X (Linking)
VI  - 37
IP  - 1
DP  - 2011 Jun
TI  - Black, white or green: 'race', gender and avatars within the therapeutic space.
PG  - 9-12
LID - 10.1136/jmh.2010.005637 [doi]
AB  - Personal identity is critical to provider--patient interactions. Patients and
      doctors tend to self-select, ideally forming therapeutic units that maximise the 
      patients' benefit. Recently, however, 'reality' has changed. The internet and
      virtual worlds such as Second Life (http://www.secondlife.com/) allow models of
      identity and provider--patient interactions that go beyond the limits of
      mainstream personal identity. In this paper some of the ethical implications of
      virtual patient--provider interactions, especially those that have to do with
      personal identity, are explored.
FAU - Graber, Mark A
AU  - Graber MA
AD  - Department of Emergency Medicine, University of Iowa Carver College of Medicine, 
      Iowa 52242, USA. mark-graber@uiowa.edu
FAU - Graber, Abraham D
AU  - Graber AD
LA  - eng
PT  - Journal Article
DEP - 20110217
PL  - United States
TA  - Med Humanit
JT  - Medical humanities
JID - 100959585
SB  - IM
MH  - Deception
MH  - Female
MH  - *Gender Identity
MH  - Humans
MH  - *Identification, Psychological
MH  - *Internet
MH  - Male
MH  - *Professional-Patient Relations/ethics
MH  - *Racial Groups
MH  - Social Networking
MH  - Telemedicine/ethics/*methods
EDAT- 2011/05/20 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/05/20 06:00
PHST- 2011/05/20 06:00 [entrez]
PHST- 2011/05/20 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - jmh.2010.005637 [pii]
AID - 10.1136/jmh.2010.005637 [doi]
PST - ppublish
SO  - Med Humanit. 2011 Jun;37(1):9-12. doi: 10.1136/jmh.2010.005637. Epub 2011 Feb 17.


PMID- 21592923
OWN - NLM
STAT- MEDLINE
DCOM- 20111222
LR  - 20110530
IS  - 1308-0032 (Electronic)
IS  - 1302-8723 (Linking)
VI  - 11
IP  - 4
DP  - 2011 Jun
TI  - A statement on ethics from the HEART Group.
PG  - 363-5
LID - 10.5152/akd.2011.103 [doi]
CN  - HEART Group
LA  - eng
PT  - Journal Article
DEP - 20110518
PL  - Turkey
TA  - Anadolu Kardiyol Derg
JT  - Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology
JID - 101095069
SB  - IM
MH  - Cardiology/*ethics
MH  - Editorial Policies
MH  - *Ethics, Research
MH  - Humans
MH  - Periodicals as Topic/*ethics
MH  - *Scientific Misconduct
MH  - Societies
MH  - Turkey
IR  - Ector H
FIR - Ector, Hugo
IR  - Lancellotti P
FIR - Lancellotti, Patrizio
IR  - Roberts WC
FIR - Roberts, William C
IR  - Wenger NK
FIR - Wenger, Nanette K
IR  - Moss AJ
FIR - Moss, Arthur J
IR  - Smith ER
FIR - Smith, Eldon R
IR  - Borer JS
FIR - Borer, Jeffrey S
IR  - Eagle KA
FIR - Eagle, Kim A
IR  - Freedman J
FIR - Freedman, Jane
IR  - Krum H
FIR - Krum, Henry
IR  - Lang C
FIR - Lang, Chim
IR  - Remme WJ
FIR - Remme, Willem J
IR  - Piper HM
FIR - Piper, Hans Michael
IR  - White CJ
FIR - White, Christopher J
IR  - Loscalzo J
FIR - Loscalzo, Joseph
IR  - Marban E
FIR - Marban, Eduardo
IR  - Sobel BE
FIR - Sobel, Burton E
IR  - Roberts R
FIR - Roberts, Robert
IR  - Rahimtoola SH
FIR - Rahimtoola, Shahbudin H
IR  - Camm AJ
FIR - Camm, A John
IR  - Van de Werf F
FIR - Van de Werf, Frans
IR  - Swedberg K
FIR - Swedberg, Karl
IR  - Timmis AD
FIR - Timmis, Adam D
IR  - Stone KS
FIR - Stone, Kathleen S
IR  - Zipes DP
FIR - Zipes, Douglas P
IR  - Iosseliani DG
FIR - Iosseliani, David G
IR  - Taylor AJ
FIR - Taylor, Allen J
IR  - Rosen MR
FIR - Rosen, Michael R
IR  - Grines CL
FIR - Grines, Cindy L
IR  - DeMaria AN
FIR - DeMaria, Anthony N
IR  - Narula J
FIR - Narula, Jagat
IR  - King SB 3rd
FIR - King, Spencer B 3rd
IR  - Wagner GS
FIR - Wagner, Galen S
IR  - Saksena S
FIR - Saksena, Sanjeev
IR  - Pearlman AS
FIR - Pearlman, Alan S
IR  - Bodnar E
FIR - Bodnar, Endre
IR  - Emery RW
FIR - Emery, Robert W
IR  - Cohn LH
FIR - Cohn, Lawrence H
IR  - van der Wall EE
FIR - van der Wall, Ernst E
IR  - Abdulla RI
FIR - Abdulla, Ra-id
IR  - Lesch M
FIR - Lesch, Michael
IR  - Alfonso F
FIR - Alfonso, Fernando
IR  - Ekroth R
FIR - Ekroth, Rolf
IR  - Timuralp B
FIR - Timuralp, Bilgin
EDAT- 2011/05/20 06:00
MHDA- 2011/12/23 06:00
CRDT- 2011/05/20 06:00
PHST- 2011/05/20 06:00 [entrez]
PHST- 2011/05/20 06:00 [pubmed]
PHST- 2011/12/23 06:00 [medline]
AID - 10.5152/akd.2011.103 [doi]
PST - ppublish
SO  - Anadolu Kardiyol Derg. 2011 Jun;11(4):363-5. doi: 10.5152/akd.2011.103. Epub 2011
      May 18.


PMID- 21592684
OWN - NLM
STAT- MEDLINE
DCOM- 20120123
LR  - 20181201
IS  - 1873-2542 (Electronic)
IS  - 0378-1135 (Linking)
VI  - 153
IP  - 1-2
DP  - 2011 Nov 21
TI  - Relevance in pathogenesis research.
PG  - 2-12
LID - 10.1016/j.vetmic.2011.04.020 [doi]
AB  - Research on pathogenesis of bacterial diseases involves exploration of the
      intricate and complex interactions among pathogen, host, and environment.
      Host-parasite-environment interactions that were relatively simple were the first
      to be understood. They include intoxications in which ingestion of a powerful
      bacterial toxin was sufficient to cause disease. In more complex cases bacteria
      occupy a variety of niches in the host and attack at an opportune time. Some
      bacterial pathogens have a brief encounter with the host; others are long-term
      guests. This variety of relationships involves a wide range of strategies for
      survival and transmission of bacterial pathogens. Molecular genetics, genomics
      and proteomics have facilitated understanding of the pathogens and hosts. Massive
      information often results from such studies and determining the relevance of the 
      data is frequently a challenge. In vitro studies often attempt to simulate one or
      two critical aspects of the environment, such as temperature, pH, and iron
      concentration, that may provide clues as to what goes on in the host. These
      studies sometimes identify critical bacterial virulence factors but regulation of
      bacterial virulence and host response is complex and often not well understood.
      Pathogenesis is a process of continuous change in which timing and degree of gene
      expression are critical and are highly regulated by the environment. It is
      impossible to get the full picture without the use of natural or experimental
      infections, although experimental infections involve ethical and economic
      considerations which may act as a deterrent.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Gyles, Carlton L
AU  - Gyles CL
AD  - Department of Pathobiology, University of Guelph, Guelph, Ontario, N1G 2W1
      Canada. cgyles@uoguelph.ca
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110422
PL  - Netherlands
TA  - Vet Microbiol
JT  - Veterinary microbiology
JID - 7705469
RN  - 0 (Virulence Factors)
SB  - IM
MH  - Animals
MH  - Bacteria/immunology/*pathogenicity
MH  - Bacterial Infections/immunology/*microbiology
MH  - *Host-Parasite Interactions
MH  - Humans
MH  - Virulence
MH  - Virulence Factors/metabolism
EDAT- 2011/05/20 06:00
MHDA- 2012/01/24 06:00
CRDT- 2011/05/20 06:00
PHST- 2010/12/23 00:00 [received]
PHST- 2011/04/09 00:00 [revised]
PHST- 2011/04/13 00:00 [accepted]
PHST- 2011/05/20 06:00 [entrez]
PHST- 2011/05/20 06:00 [pubmed]
PHST- 2012/01/24 06:00 [medline]
AID - S0378-1135(11)00234-3 [pii]
AID - 10.1016/j.vetmic.2011.04.020 [doi]
PST - ppublish
SO  - Vet Microbiol. 2011 Nov 21;153(1-2):2-12. doi: 10.1016/j.vetmic.2011.04.020. Epub
      2011 Apr 22.


PMID- 21592264
OWN - NLM
STAT- MEDLINE
DCOM- 20110907
LR  - 20220129
IS  - 1369-7625 (Electronic)
IS  - 1369-6513 (Linking)
VI  - 14
IP  - 2
DP  - 2011 Jun
TI  - Shared decision making: trade-offs between narrower and broader conceptions.
PG  - 210-9
LID - 10.1111/j.1369-7625.2011.00694.x [doi]
AB  - Shared decision-making approaches, by recognizing the autonomy and responsibility
      of both health professionals and patients, aim for an ethical 'middle way'
      between 'paternalistic' and 'consumerist' models of clinical decision making.
      Shared decision making has been understood in various ways. In this paper, we
      distinguish narrow and broader conceptions of shared decision making and explore 
      their relative strengths and weaknesses. In the first part of the paper, we
      construct a summary characterization of an archetypal narrow conception of shared
      decision making (a conception that does not coincide with any specific published 
      model but which reflects features of a variety of models). We show the
      shortcomings of such a conception and highlight the need to broaden out our
      thinking about shared decision making if the ethical (and instrumental) goals of 
      shared decision making are to be realized. In the second part of the paper, we
      acknowledge and explore the advantages and disadvantages of operating with
      broader conceptions of shared decision making by considering the analogies
      between health professional-patient relationships and familiar examples of
      'open-ended' relationships (e.g. friendships). We conclude by arguing that the
      illustrated 'trade-offs' between narrow conceptions (which may protect patients
      from inappropriately paternalistic professionals but preclude important forms of 
      professional support) and broad conceptions (which render more forms of
      professional support legitimate but may require skills or virtues that not all
      health professionals possess) suggest the need to find ways, in principle and in 
      practice, of taking seriously both patient autonomy and autonomy-supportive
      professional intervention.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Cribb, Alan
AU  - Cribb A
AD  - Centre for Public Policy Research, King's College, London. alan.cribb@kcl.ac.uk
FAU - Entwistle, Vikki A
AU  - Entwistle VA
LA  - eng
GR  - HSRU2/CSO_/Chief Scientist Office/United Kingdom
PT  - Comment
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Health Expect
JT  - Health expectations : an international journal of public participation in health 
      care and health policy
JID - 9815926
SB  - IM
CON - Health Expect. 2011 Jun;14(2):178-81. PMID: 21592263
MH  - *Decision Making/ethics
MH  - Humans
MH  - Patient Advocacy
MH  - Patient Rights
MH  - Personal Autonomy
MH  - Professional Autonomy
MH  - *Professional-Patient Relations/ethics
PMC - PMC5060567
EDAT- 2011/05/20 06:00
MHDA- 2011/09/08 06:00
CRDT- 2011/05/20 06:00
PHST- 2011/05/20 06:00 [entrez]
PHST- 2011/05/20 06:00 [pubmed]
PHST- 2011/09/08 06:00 [medline]
AID - 10.1111/j.1369-7625.2011.00694.x [doi]
PST - ppublish
SO  - Health Expect. 2011 Jun;14(2):210-9. doi: 10.1111/j.1369-7625.2011.00694.x.


PMID- 21592188
OWN - NLM
STAT- MEDLINE
DCOM- 20111227
LR  - 20151119
IS  - 1365-2648 (Electronic)
IS  - 0309-2402 (Linking)
VI  - 67
IP  - 11
DP  - 2011 Nov
TI  - Effects of a blended learning module on self-reported learning performances in
      baccalaureate nursing students.
PG  - 2435-44
LID - 10.1111/j.1365-2648.2011.05684.x [doi]
AB  - AIMS: This article is a report of a quasi-experimental study of the effects of
      blended modules on nursing students' learning of ethics course content.
      BACKGROUND: There is yet to be an empirically supported mix of strategies on
      which a working blended learning model can be built for nursing education.
      METHODS: This was a two-group pretest and post-test quasi-experimental study in
      2008 involving a total of 233 students. Two of the five clusters were designated 
      the experimental group to experience a blended learning model, and the rest were 
      designated the control group to be given classroom lectures only. The Case
      Analysis Attitude Scale, Case Analysis Self-Evaluation Scale, Blended Learning
      Satisfaction Scale, and Metacognition Scale were used in pretests and post-tests 
      for the students to rate their own performance. RESULTS: In this study, the
      experimental group did not register significantly higher mean scores on the Case 
      Analysis Attitude Scale at post-test and higher mean ranks on the Case Analysis
      Self-Evaluation Scale, the Blended Learning Satisfaction Scale, and the
      Metacognition Scale at post-test than the control group. Moreover, the
      experimental group registered significant progress in the mean ranks on the Case 
      Analysis Self-Evaluation Scale and the Metacognition Scale from pretest to
      post-test. CONCLUSIONS: No between-subjects effects of four scales at post-test
      were found. Newly developed course modules, be it blended learning or a
      combination of traditional and innovative components, should be tested repeatedly
      for effectiveness and popularity for the purpose of facilitating the ultimate
      creation of a most effective course module for nursing education.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Hsu, Li-Ling
AU  - Hsu LL
AD  - Graduate Institute of Health Allied Education, National Taipei University of
      Nursing and Health Sciences, Beitou, Taiwan. llhsu@ntunhs.edu.tw
FAU - Hsieh, Suh-Ing
AU  - Hsieh SI
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110519
PL  - England
TA  - J Adv Nurs
JT  - Journal of advanced nursing
JID - 7609811
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Computer-Assisted Instruction
MH  - Data Interpretation, Statistical
MH  - Education, Nursing, Baccalaureate/*methods
MH  - Educational Measurement/statistics & numerical data
MH  - Ethics, Nursing/*education
MH  - Humans
MH  - *Learning
MH  - Nursing Evaluation Research
MH  - Program Evaluation/statistics & numerical data
MH  - Students, Nursing/*psychology
MH  - *Surveys and Questionnaires
MH  - Young Adult
EDAT- 2011/05/20 06:00
MHDA- 2011/12/28 06:00
CRDT- 2011/05/20 06:00
PHST- 2011/05/20 06:00 [entrez]
PHST- 2011/05/20 06:00 [pubmed]
PHST- 2011/12/28 06:00 [medline]
AID - 10.1111/j.1365-2648.2011.05684.x [doi]
PST - ppublish
SO  - J Adv Nurs. 2011 Nov;67(11):2435-44. doi: 10.1111/j.1365-2648.2011.05684.x. Epub 
      2011 May 19.


PMID- 21592068
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20191112
IS  - 2212-3938 (Electronic)
IS  - 1574-8847 (Linking)
VI  - 6
IP  - 2
DP  - 2011 May
TI  - It is now personal: recent views on the assessment of therapeutic infidelity in
      severe mental illness.
PG  - 78-82
AB  - This paper starts with an attempt to chart the contemporary history of the term
      "Compliance" and its cognates. It also discusses the recently published
      guidelines concerning the assessment of adherence in patients with serious mental
      illnesses, dedicating its middle part to comment on the research and clinical
      methods to assess adherence in patients. The current consensus amongst experts
      can be summarized, from a clinical point of view, in a simple rule of thumb:
      enhancing adherence should depend on simple interventions originating from a
      multidisciplinary perspective and should include patients' input. Despite its
      apparent simplicity, improving the assessment of adherence and favouring its
      enhancement can generate interesting ethical quandaries that will be approached
      in the light of the relatively new emergent notion of "moral distress.".
FAU - Cabrera-Abreu, Casimiro
AU  - Cabrera-Abreu C
AD  - Queen's University Department of Psychiatry, Providence Care Mental Health
      Services, Kingston, ON, Canada. cabrerac@queensu.ca
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Clin Pharmacol
JT  - Current clinical pharmacology
JID - 101273158
SB  - IM
MH  - Humans
MH  - *Medication Adherence
MH  - Mental Disorders/*drug therapy
MH  - Morals
EDAT- 2011/05/20 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/05/20 06:00
PHST- 2011/02/24 00:00 [received]
PHST- 2011/04/27 00:00 [accepted]
PHST- 2011/05/20 06:00 [entrez]
PHST- 2011/05/20 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - BSP/CCP/E-Pub/0038 [pii]
AID - 10.2174/157488411796151138 [doi]
PST - ppublish
SO  - Curr Clin Pharmacol. 2011 May;6(2):78-82. doi: 10.2174/157488411796151138.


PMID- 21592022
OWN - NLM
STAT- MEDLINE
DCOM- 20120109
LR  - 20220409
IS  - 1466-187X (Electronic)
IS  - 0142-159X (Linking)
VI  - 33
IP  - 9
DP  - 2011
TI  - Academic dishonesty among undergraduates from private medical schools in India.
      Are we on the right track?
PG  - 759-61
LID - 10.3109/0142159X.2011.576717 [doi]
AB  - BACKGROUND: Though doctors are considered to be respectful role models of
      professionalism and ethics, medical students are no strangers to academic
      dishonesty. AIM: To assess the academic dishonesty practices among undergraduate 
      students from private medical schools in India. METHODS: A pre-tested and
      validated questionnaire containing 10 commonly done academic misconducts were
      administered and responses were collected. RESULTS: Out of 166 medical students
      enrolled in the study, 75% have given proxy for attendance and 49% have copied
      from others record book. During a theory exam, 74% of students have copied from
      their friends, 2% have tried to get the question paper before exam and 5% have
      influenced their teachers by unfair means to get more marks. During
      clinical/practical exam, 81% have got technical help, 45% had prior knowledge
      about the exam case, and 54% of them have falsely documented clinical findings.
      CONCLUSIONS: The prevalence of academic dishonesty is high. Academic integrity
      and ethics should be emphasized to the students which might help them in becoming
      professional and honest doctors.
FAU - Babu, Thirunavukkarasu Arun
AU  - Babu TA
AD  - Sri Lakshmi Narayana Institute of Medical Sciences (SLIMS), India.
      babuarun@yahoo.com
FAU - Joseph, Noyal Mariya
AU  - Joseph NM
FAU - Sharmila, Vijayan
AU  - Sharmila V
LA  - eng
PT  - Journal Article
DEP - 20110519
PL  - England
TA  - Med Teach
JT  - Medical teacher
JID - 7909593
SB  - IM
MH  - *Deception
MH  - *Education, Medical, Undergraduate
MH  - Female
MH  - Humans
MH  - India
MH  - Male
MH  - *Schools, Medical
MH  - *Students, Medical
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2011/05/20 06:00
MHDA- 2012/01/10 06:00
CRDT- 2011/05/20 06:00
PHST- 2011/05/20 06:00 [entrez]
PHST- 2011/05/20 06:00 [pubmed]
PHST- 2012/01/10 06:00 [medline]
AID - 10.3109/0142159X.2011.576717 [doi]
PST - ppublish
SO  - Med Teach. 2011;33(9):759-61. doi: 10.3109/0142159X.2011.576717. Epub 2011 May
      19.


PMID- 21591431
OWN - NLM
STAT- MEDLINE
DCOM- 20110708
LR  - 20110727
IS  - 0047-1852 (Print)
IS  - 0047-1852 (Linking)
VI  - 69
IP  - 4
DP  - 2011 Apr
TI  - [Medical ethics in terminal stage viewed from emergency and critical care in
      Japan].
PG  - 730-5
AB  - In Japan, several types of the proposal for terminal care have been published by 
      Medical Association, Ministry of Health, Labor and Welfare, etc. Among them, the 
      guidelines proposed by Japanese Association for Acute Medicine (JAAM) are
      appreciated as most concretely expressed ethically as well as practically
      regarding the judgment of terminal stages, the medical ethics needed through the 
      processes thereafter and the methods on withdrawal or withholding in terminal
      care. The author explained and considered the terminal care provided by medical
      professionals for the absolutely desperate including the brain dead following
      post-cardiac arrest syndrome for instance, according to the guidelines by JAAM.
      The best practice selected for the terminally ill ought to be reasonable and
      suitable from the aspects of both medical science and ethics.
FAU - Aruga, Tohru
AU  - Aruga T
AD  - Department of Emergency and Critical Care Medicine, Showa University School of
      Medicine.
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Nihon Rinsho
JT  - Nihon rinsho. Japanese journal of clinical medicine
JID - 0420546
SB  - IM
MH  - *Critical Care
MH  - *Emergency Medical Services
MH  - *Ethics, Medical
MH  - Humans
MH  - Japan
MH  - Practice Guidelines as Topic
MH  - *Terminal Care
MH  - Withholding Treatment
EDAT- 2011/05/20 06:00
MHDA- 2011/07/09 06:00
CRDT- 2011/05/20 06:00
PHST- 2011/05/20 06:00 [entrez]
PHST- 2011/05/20 06:00 [pubmed]
PHST- 2011/07/09 06:00 [medline]
PST - ppublish
SO  - Nihon Rinsho. 2011 Apr;69(4):730-5.


PMID- 21591373
OWN - NLM
STAT- MEDLINE
DCOM- 20110623
LR  - 20110518
IS  - 0241-6972 (Print)
IS  - 0241-6972 (Linking)
IP  - 274
DP  - 2011 May-Jun
TI  - [The therapeutic stay, a clinical, ethical and political act].
PG  - 13
FAU - Touzet, Patrick
AU  - Touzet P
LA  - fre
PT  - Introductory Journal Article
TT  - Le sejour therapeutique, un acte clinique, ethique et politique.
PL  - France
TA  - Soins Psychiatr
JT  - Soins. Psychiatrie
JID - 8203334
MH  - *Ethics, Nursing
MH  - France
MH  - Humans
MH  - Mental Disorders/*nursing/rehabilitation
MH  - *Patient Admission
MH  - *Politics
EDAT- 2011/05/20 06:00
MHDA- 2011/06/24 06:00
CRDT- 2011/05/20 06:00
PHST- 2011/05/20 06:00 [entrez]
PHST- 2011/05/20 06:00 [pubmed]
PHST- 2011/06/24 06:00 [medline]
PST - ppublish
SO  - Soins Psychiatr. 2011 May-Jun;(274):13.


PMID- 21590657
OWN - NLM
STAT- MEDLINE
DCOM- 20120113
LR  - 20110815
IS  - 1439-359X (Electronic)
IS  - 0939-7248 (Linking)
VI  - 21
IP  - 4
DP  - 2011 Aug
TI  - Failure to report ethical approval and informed consent in paediatric surgical
      publications.
PG  - 215-9
LID - 10.1055/s-0031-1277145 [doi]
AB  - INTRODUCTION: Medical research involving human subjects must follow ethical
      standards as outlined in the Declaration of Helsinki of the World Medical
      Association. The 3 journals J Ped Surg, Eur J Pediatr Surg and Pediatr Surg Int
      all require authors' statements regarding ethical approval and the patient or
      guardian informed consent for studies involving human subjects. It has previously
      been reported that ethical approval and informed consent is not documented in a
      considerable proportion of publications in other journals. The aim of this study 
      was to investigate whether ethical approval and informed consent was documented
      in a consecutive series of publications involving human subjects in the 3
      paediatric surgical journals. MATERIAL AND METHODS: All articles involving human 
      subjects or material published in the print and online issues of J Ped Surg, Eur 
      J Pediatr Surg and Pediatr Surg Int in 2010 were systematically reviewed as to
      whether ethics committee or institutional review board approval and patient or
      guardian consent to participate in the study was reported. Publications were
      categorised into prospective studies, retrospective studies, description of new
      methods and case reports. RESULTS: 579 articles were included in the study (324 J
      Ped Surg, 103 Eur J Pediatr Surg and 153 Pediatr Surg Int). In case reports
      (n=142), the lowest level of documentation of ethical approval (1.4%) and
      informed consent (1%) was observed. The remaining 437 original articles reported 
      ethical approval in 54% of publications (prospective studies 66%, retrospective
      studies 59%, new methods 27%). Informed consent was documented in 16% of the
      original articles (prospective studies 50%, retrospective studies 17%, new
      methods 14%). Detailed investigation of the different journals revealed the
      highest rate of reporting of ethical approval for J Pediatr Surg (71%), followed 
      by Eur J Pediatr Surg (43%), and Pediatr Surg Int (24%). Patient or guardian
      informed consent was reported in 15% of the publications in J Pediatr Surg and
      Pediatr Surg Int, respectively, and in 24% of the papers published in Eur J
      Pediatr Surg. CONCLUSION: Adherence to ethical principles in paediatric surgical 
      research should be improved. Information on ethical approval and informed consent
      should be included in all manuscripts accepted for publication. Editors should
      consider establishing a specific online template asking authors for the necessary
      information during the submission process.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Dingemann, J
AU  - Dingemann J
AD  - Centre of Pediatric Surgery Hannover Medical School and Bult Children's Hospital,
      Hannover, Germany.
FAU - Dingemann, C
AU  - Dingemann C
FAU - Ure, B
AU  - Ure B
LA  - eng
PT  - Journal Article
DEP - 20110517
PL  - United States
TA  - Eur J Pediatr Surg
JT  - European journal of pediatric surgery : official journal of Austrian Association 
      of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie
JID - 9105263
SB  - IM
MH  - Bibliometrics
MH  - *Ethics, Research
MH  - Helsinki Declaration
MH  - Humans
MH  - Informed Consent/*statistics & numerical data
MH  - Pediatrics/*ethics
MH  - Periodicals as Topic/*ethics/statistics & numerical data
MH  - Specialties, Surgical/*ethics
EDAT- 2011/05/19 06:00
MHDA- 2012/01/14 06:00
CRDT- 2011/05/19 06:00
PHST- 2011/05/19 06:00 [entrez]
PHST- 2011/05/19 06:00 [pubmed]
PHST- 2012/01/14 06:00 [medline]
AID - 10.1055/s-0031-1277145 [doi]
PST - ppublish
SO  - Eur J Pediatr Surg. 2011 Aug;21(4):215-9. doi: 10.1055/s-0031-1277145. Epub 2011 
      May 17.


PMID- 21590490
OWN - NLM
STAT- MEDLINE
DCOM- 20110823
LR  - 20110621
IS  - 1432-0851 (Electronic)
IS  - 0340-7004 (Linking)
VI  - 60
IP  - 7
DP  - 2011 Jul
TI  - Gastric type I carcinoid: a pilot study with human G17DT immunogen vaccination.
PG  - 1057-60
LID - 10.1007/s00262-011-1031-5 [doi]
AB  - CONTEXT: Gastric type I carcinoid is a rare neoplasm, deriving from
      enterochromaffin-like cells (ECL), mainly affecting women with autoimmune
      gastritis. The approach to treatment, either endoscopic, medical or surgical, is 
      not well defined, particularly in multifocal tumours or carcinoids with rapid
      growth/frequent recurrence. OBJECTIVE: To determine whether an anti-G17
      vaccination might interfere on the natural history of gastric type I carcinoid.
      SETTING: Padua teaching Hospital, outpatient clinic. DESIGN AND PATIENTS: Three
      patients with type I gastric carcinoid in autoimmune gastritis were administered,
      after informed consent and ethic committee approval, with a vaccine against
      gastrin 17 (G17), a synthetic peptide that stimulates specific and high-affinity 
      anti-G17 antibodies, and followed up endoscopically and clinically for a mean of 
      36 months. MAIN OUTCOME MEASURES: Gastric histology and specifically carcinoid
      growth/recurrence and trend in time in gastrin, G17, pepsinogens, chromogranin A 
      and clinical parameters. RESULTS: Following vaccination, carcinoid regression was
      observed in 2/3 patients and, in one of the patients, even the disappearance of
      ECL hyperplasia, with a reduced ECL cells stimulation, confirmed by a significant
      reduction in chromogranin A levels. Regression was observed in the two patients
      that showed a more clear local response to the vaccine. Increased autoantibody
      titre was observed, but no appearance of new autoimmune diseases. CONCLUSIONS:
      Anti-G17 vaccination induced regression of type I gastric carcinoid and could be 
      considered for the treatment of this tumour, when endoscopic removal is not
      indicated.
FAU - Tieppo, Chiara
AU  - Tieppo C
AD  - Department of Surgical and Gastroenterological Sciences, Policlinico
      Universitario, Via Giustiniani 2, Padua, Italy.
FAU - Betterle, Corrado
AU  - Betterle C
FAU - Basso, Daniela
AU  - Basso D
FAU - Mescoli, Claudia
AU  - Mescoli C
FAU - Rugge, Massimo
AU  - Rugge M
FAU - Martini, Chiara
AU  - Martini C
FAU - Zorzetto, Valerio
AU  - Zorzetto V
FAU - Maddalo, Gemma
AU  - Maddalo G
FAU - Cazzagon, Nora
AU  - Cazzagon N
FAU - Nitti, Donato
AU  - Nitti D
FAU - Farinati, Fabio
AU  - Farinati F
LA  - eng
PT  - Journal Article
DEP - 20110518
PL  - Germany
TA  - Cancer Immunol Immunother
JT  - Cancer immunology, immunotherapy : CII
JID - 8605732
RN  - 0 (Cancer Vaccines)
RN  - 0 (Gastrins)
RN  - 0 (gastrin immunogen)
SB  - IM
MH  - Aged
MH  - Cancer Vaccines/*administration & dosage
MH  - Carcinoid Tumor/immunology/*prevention & control
MH  - Female
MH  - Gastrins/*administration & dosage
MH  - Gastritis, Atrophic/immunology/prevention & control
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Male
MH  - Pilot Projects
MH  - Prognosis
MH  - Stomach Neoplasms/immunology/*prevention & control
MH  - Survival Rate
MH  - Tumor Microenvironment
MH  - Vaccination
EDAT- 2011/05/19 06:00
MHDA- 2011/08/24 06:00
CRDT- 2011/05/19 06:00
PHST- 2010/10/27 00:00 [received]
PHST- 2011/04/30 00:00 [accepted]
PHST- 2011/05/19 06:00 [entrez]
PHST- 2011/05/19 06:00 [pubmed]
PHST- 2011/08/24 06:00 [medline]
AID - 10.1007/s00262-011-1031-5 [doi]
PST - ppublish
SO  - Cancer Immunol Immunother. 2011 Jul;60(7):1057-60. doi:
      10.1007/s00262-011-1031-5. Epub 2011 May 18.


PMID- 21590407
OWN - NLM
STAT- MEDLINE
DCOM- 20110901
LR  - 20121115
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Linking)
VI  - 737
DP  - 2011
TI  - Ethical consideration.
PG  - 407-24
LID - 10.1007/978-1-61779-095-9_17 [doi]
AB  - The twofold distinction between interventions into the germ line and
      interventions into somatic cells on the one hand and between the treatment of
      diseases and enhancement on the other hand resulted in the concept of somatic
      gene therapy. There is a nearly unanimous agreement that somatic gene therapy has
      a high-ranking moral objective and uses methods that extend current techniques
      for treating diseases in a morally acceptable way. In its experimental phase
      principles of research ethics as the autonomy and the informed consent of the
      patient or the test person, a fair selection of test persons and a careful
      weighing of risks and benefits have to be taken into account and several specific
      points have to be considered. Experimental somatic gene therapy requires a
      positive vote of a competent and independent ethics committee.
FAU - Fuchs, Michael
AU  - Fuchs M
AD  - Institut fur Wissenschaft und Ethik, University Bonn, Bonn, Germany.
      fuchs@iwe.uni-bonn.de
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
SB  - IM
MH  - Clinical Trials as Topic/*ethics
MH  - Ethics Committees, Research/organization & administration
MH  - Genetic Enhancement/ethics
MH  - Genetic Therapy/*ethics/legislation & jurisprudence
MH  - Heredity
MH  - Humans
MH  - Public Opinion
EDAT- 2011/05/19 06:00
MHDA- 2011/09/02 06:00
CRDT- 2011/05/19 06:00
PHST- 2011/05/19 06:00 [entrez]
PHST- 2011/05/19 06:00 [pubmed]
PHST- 2011/09/02 06:00 [medline]
AID - 10.1007/978-1-61779-095-9_17 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2011;737:407-24. doi: 10.1007/978-1-61779-095-9_17.


PMID- 21587000
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20110518
IS  - 1538-1145 (Electronic)
IS  - 1527-4160 (Linking)
VI  - 17
IP  - 3
DP  - 2011 May
TI  - So they want you to be their medical director.
PG  - 208-11
LID - 10.1097/01.pra.0000398415.89986.18 [doi]
AB  - Clinicians, especially physicians, who become "medical directors" of facilities
      or agencies incur more responsibilities than they sometimes realize. Clinical
      administration, such as medical director roles and duties, creates personal,
      professional, management, and forensic issues. For some, their day-to-day work
      changes little; others experience a shift in duties and relationships,
      particularly duties to and relationships with the organization (as contrasted
      with its patients) that are unfamiliar to most clinical professionals. One who
      accepts such a position should understand the organization's needs and
      expectations and, within bounds of professional ethics, be prepared to meet them.
      Even medical directors of very small organizations, such as small private
      hospitals or clinics, routinely, and sometimes unknowingly, incur administrative 
      and/or legal responsibilities for which they may later be held accountable.
FAU - Reid, William H
AU  - Reid WH
AD  - American Academy of Psychiatry and the Law, USA. www.psychandlaw.org
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Psychiatr Pract
JT  - Journal of psychiatric practice
JID - 100901141
SB  - IM
MH  - Ethics, Institutional
MH  - Health Facility Administration/legislation & jurisprudence/*standards
MH  - Humans
MH  - Interdisciplinary Communication
MH  - *Physician Executives/ethics/legislation & jurisprudence/psychology/standards
MH  - *Public Relations
MH  - *Social Adjustment
MH  - Social Conformity
MH  - Social Responsibility
EDAT- 2011/05/19 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/05/19 06:00
PHST- 2011/05/19 06:00 [entrez]
PHST- 2011/05/19 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - 10.1097/01.pra.0000398415.89986.18 [doi]
AID - 00131746-201105000-00008 [pii]
PST - ppublish
SO  - J Psychiatr Pract. 2011 May;17(3):208-11. doi:
      10.1097/01.pra.0000398415.89986.18.


PMID- 21586403
OWN - NLM
STAT- MEDLINE
DCOM- 20120103
LR  - 20161125
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 10
DP  - 2011 Oct
TI  - Readiness for legally literate medical practice? Student perceptions of their
      undergraduate medico-legal education.
PG  - 616-22
LID - 10.1136/jme.2010.041566 [doi]
AB  - Medical councils increasingly require graduates to understand law and to practise
      medicine mindful of the legal rules. In the UK a revised curriculum for medical
      law and ethics has been published. However, coverage of law in medical education 
      remains variable and doubts exist about how far students acquire legal knowledge 
      and skills in its implementation. This survey of students in two UK medical
      schools measured their law learning and their confidence in using this knowledge.
      Concept maps and a self-audit questionnaire were used to capture students'
      understanding and perceptions of this knowledge domain and self-assessments of
      their legal knowledge and skills. A large sample was achieved across first,
      second and final year students. Students agree that a sound understanding of law 
      is essential to being a good doctor. Their perceptions of law are generally
      positive but the interface between the legal rules and codes of medical ethics
      creates difficulty. In some areas students offer relatively confident
      self-assessments of their legal knowledge and skills for practising law. However,
      levels of confidence in other areas of their law learning raise doubts about the 
      degree to which they can advocate for and protect their patients. Conclusions are
      drawn about the effectiveness of students' law learning and recommendations made 
      for further research.
FAU - Preston-Shoot, Michael
AU  - Preston-Shoot M
AD  - Faculty of Health and Social Sciences, University of Bedfordshire, Park Square,
      Luton, England, UK. michael.preston-shoot@beds.ac.uk
FAU - McKimm, Judy
AU  - McKimm J
FAU - Kong, Wing May
AU  - Kong WM
FAU - Smith, Sue
AU  - Smith S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110516
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Curriculum/*standards
MH  - Education, Medical, Undergraduate/*methods
MH  - Ethics, Medical/education
MH  - Humans
MH  - *Jurisprudence
MH  - Schools, Medical/*standards
MH  - Students, Medical/*psychology
MH  - United Kingdom
EDAT- 2011/05/19 06:00
MHDA- 2012/01/04 06:00
CRDT- 2011/05/19 06:00
PHST- 2011/05/19 06:00 [entrez]
PHST- 2011/05/19 06:00 [pubmed]
PHST- 2012/01/04 06:00 [medline]
AID - jme.2010.041566 [pii]
AID - 10.1136/jme.2010.041566 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Oct;37(10):616-22. doi: 10.1136/jme.2010.041566. Epub 2011 May
      16.


PMID- 21586382
OWN - NLM
STAT- MEDLINE
DCOM- 20110728
LR  - 20110518
IS  - 2115-8789 (Print)
IS  - 2115-7863 (Linking)
VI  - 9
IP  - 1
DP  - 2011 Mar
TI  - [Support for patients with Alzheimer's disease and their caregivers by
      gerontechnology].
PG  - 91-100
LID - 10.1684/pnv.2010.0248 [doi]
AB  - The increasing number of people suffering from Alzheimer's disease raises the
      question of their caring at home, especially when the disease causes disability
      and negative consequences in daily life such as isolation, falls, wandering,
      errors in drug taking. Furthermore, caregivers bear a substantial burden that can
      have adverse effects on their physical and mental health. New technologies of
      information could play an additional role as care providers without substituting 
      family or professional caregivers help. A review of literature focused on the
      different technological solutions conceived for patients suffering from
      Alzheimer's disease and their carers shows that these appliances could help to
      provide reminders in daily life (drugs, tasks and appointments, meals cooking),
      to activate residual cognitive resources by computerized cognitive stimulation
      intervention, to reduce stress, anxiety and depressive symptoms in patients by
      visual contact with families and professionals (webconference), to contribute to 
      patients safety by detecting falls and wandering, and to help families in the
      caring of patients with computerized information and counselling interventions.
      We also discuss the current limitations for a widespread use of these
      technologies and outline future research avenues. True needs of end-users are
      still poorly known and should be more clearly defined. Simplicity of the use of
      these appliances should be further improved. Demonstration of medical and social 
      benefits for elderly people should be carried out in randomized, controlled
      studies. Ethical reflexion should be developed in conjunction with the use of
      these gerontechnologies. Finally, the economical model which would enable the
      providing of these appliances to the largest number of patients and caregivers
      should be implemented. Although these gerontechnologies are promising, research
      is still needed to tailor them properly to the needs of end-users, assess their
      benefit in ecological context of people with Alzheimer's disease in order to
      provide them with appropriate tools in daily life.
FAU - Rigaud, Anne-Sophie
AU  - Rigaud AS
AD  - Hopital Broca, Assistance publique -Hopitaux de Paris et EA 4468, Universite
      Paris Descartes. anne-sophie.rigaud@bcr.aphp.fr
FAU - Pino, Maribel
AU  - Pino M
FAU - Wu, Ya-Huei
AU  - Wu YH
FAU - DE Rotrou, Jocelyne
AU  - DE Rotrou J
FAU - Boulay, Melodie
AU  - Boulay M
FAU - Seux, Marie-Laure
AU  - Seux ML
FAU - Hugonot-Diener, Laurence
AU  - Hugonot-Diener L
FAU - DE Sant'anna, Martha
AU  - DE Sant'anna M
FAU - Moulin, Florence
AU  - Moulin F
FAU - LE Gouverneur, Gregory
AU  - LE Gouverneur G
FAU - Cristancho-Lacroix, Victoria
AU  - Cristancho-Lacroix V
FAU - Lenoir, Hermine
AU  - Lenoir H
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - L'aide aux personnes souffrant de maladie d'Alzheimer et a leurs aidants par les 
      gerontechnologies.
PL  - France
TA  - Geriatr Psychol Neuropsychiatr Vieil
JT  - Geriatrie et psychologie neuropsychiatrie du vieillissement
JID - 101553404
SB  - IM
MH  - Accidental Falls/prevention & control
MH  - Aged
MH  - Alzheimer Disease/*psychology
MH  - Automation
MH  - Caregivers/*psychology
MH  - Computer-Assisted Instruction
MH  - *Cost of Illness
MH  - France
MH  - Geographic Information Systems
MH  - Humans
MH  - *Internet
MH  - Randomized Controlled Trials as Topic
MH  - Reminder Systems
MH  - Remote Consultation
MH  - Robotics
MH  - *Self-Help Devices
MH  - *Social Support
EDAT- 2011/05/19 06:00
MHDA- 2011/07/29 06:00
CRDT- 2011/05/19 06:00
PHST- 2011/05/19 06:00 [entrez]
PHST- 2011/05/19 06:00 [pubmed]
PHST- 2011/07/29 06:00 [medline]
AID - pnv.2010.0248 [pii]
AID - 10.1684/pnv.2010.0248 [doi]
PST - ppublish
SO  - Geriatr Psychol Neuropsychiatr Vieil. 2011 Mar;9(1):91-100. doi:
      10.1684/pnv.2010.0248.


PMID- 21586188
OWN - NLM
STAT- MEDLINE
DCOM- 20110923
LR  - 20110518
IS  - 1876-8784 (Electronic)
IS  - 0028-2162 (Linking)
VI  - 155
DP  - 2011
TI  - [Priority for live kidney donors in transplantation].
PG  - A3578
AB  - Patients in the Netherlands requiring a donor kidney spend 3 to 4 years on
      average on the transplant waiting list for a kidney from a deceased donor.
      Post-mortem donor kidneys are in short supply. Consequently, over the past 15
      years, an increasingly number of living persons have donated a kidney. This
      development raises the question as to whether these donors ought to be given
      priority on the donor kidney waiting list in the event of subsequently suffering 
      from severe renal insufficiency. The Health Council of the Netherlands concludes 
      that there are sound medical-ethical and legal arguments for awarding live kidney
      donors with end-stage renal failure 500 points in the points system that
      Eurotransplant uses to determine the position on the waiting list. Adopting this 
      approach would mean that donors would qualify for pre-emptive transplant of a
      post-mortem donor kidney. The Council is of the opinion that the proposal is
      reconcilable with national and international legal rules and the principles on
      which they are based.
FAU - van de Klippe, C J Hanneke
AU  - van de Klippe CJ
AD  - Gezondheidsraad, Den Haag, the Netherlands. h.vd.klippe@gr.nl
FAU - Allers, Janneke M
AU  - Allers JM
LA  - dut
PT  - English Abstract
PT  - Journal Article
TT  - Prioriteit voormalige nierdonoren bij transplantatie.
PL  - Netherlands
TA  - Ned Tijdschr Geneeskd
JT  - Nederlands tijdschrift voor geneeskunde
JID - 0400770
SB  - IM
CIN - Ned Tijdschr Geneeskd. 2011;155:A3562. PMID: 21586187
MH  - Humans
MH  - Kidney Failure, Chronic/*surgery
MH  - Kidney Transplantation/*legislation & jurisprudence
MH  - Living Donors/*legislation & jurisprudence
MH  - Netherlands
MH  - Risk Factors
MH  - Time Factors
MH  - Tissue and Organ Procurement/*legislation & jurisprudence
MH  - *Waiting Lists
EDAT- 2011/05/19 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/05/19 06:00
PHST- 2011/05/19 06:00 [entrez]
PHST- 2011/05/19 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
PST - ppublish
SO  - Ned Tijdschr Geneeskd. 2011;155:A3578.


PMID- 21585610
OWN - NLM
STAT- MEDLINE
DCOM- 20110830
LR  - 20211203
IS  - 1523-5378 (Electronic)
IS  - 1083-4389 (Linking)
VI  - 16
IP  - 3
DP  - 2011 Jun
TI  - Efficacy of 2-week, second-line Helicobacter pylori eradication therapy using
      rabeprazole, amoxicillin, and metronidazole for the Japanese population.
PG  - 234-40
LID - 10.1111/j.1523-5378.2011.00842.x [doi]
AB  - BACKGROUND: Following the failure of first-line Helicobacter pylori eradication
      therapy using a proton pump inhibitor, amoxicillin, and clarithromycin,
      second-line therapy is conducted for 1 week using metronidazole instead of
      clarithromycin in Japan. Recent studies indicate that metronidazole-containing
      therapy has a higher eradication rate with prolonged treatment duration, even
      with metronidazole resistance. The aim of this study was to reveal the efficacy
      of 2-week metronidazole-containing second-line therapy. METHODS: Eighty-two
      consecutive outpatients who had failed in the first-line eradication therapy were
      enrolled and second-line therapy was initiated with 10 mg rabeprazole, 750 mg
      amoxicillin, and 250 mg metronidazole twice daily. After they had been screened
      by hematological examination 1 week after initiation, the treatment was continued
      for 2 weeks after initiation in patients without hematological abnormality. Cure 
      was essentially confirmed by the urea breath test. RESULTS: After one patient was
      lost, hematological examination showed elevated serum aminotransferase in 14 of
      81 patients. Although it was mild without clinical issues, they were ethically
      excluded from this study. In the remaining 67 patients and the lost patient, the 
      eradication rate with 2-week therapy was 65/68 (96%, 95% confidence interval:
      88-98%) by intention to treat analysis and 65/65 (100%, 94-100%) by per protocol 
      analysis. The main adverse event was soft stools (39%), and no serious adverse
      event was observed. CONCLUSION: This 2-week metronidazole-containing second-line 
      therapy provides high efficacy in Japan where metronidazole resistance is rare.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Hori, Kazutoshi
AU  - Hori K
AD  - Department of Intestinal Inflammation Research, Hyogo College of Medicine,
      Nishinomiya, Hyogo 663-8501, Japan. k-hori@hyo-med.ac.jp
FAU - Miwa, Hiroto
AU  - Miwa H
FAU - Matsumoto, Takayuki
AU  - Matsumoto T
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - England
TA  - Helicobacter
JT  - Helicobacter
JID - 9605411
RN  - 0 (2-Pyridinylmethylsulfinylbenzimidazoles)
RN  - 0 (Anti-Bacterial Agents)
RN  - 140QMO216E (Metronidazole)
RN  - 32828355LL (Rabeprazole)
RN  - 804826J2HU (Amoxicillin)
SB  - IM
MH  - 2-Pyridinylmethylsulfinylbenzimidazoles/*administration & dosage/adverse effects
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Amoxicillin/*administration & dosage/adverse effects
MH  - Anti-Bacterial Agents/*administration & dosage/adverse effects
MH  - Asians
MH  - Female
MH  - Helicobacter Infections/*drug therapy/microbiology
MH  - Helicobacter pylori/drug effects
MH  - Humans
MH  - Japan
MH  - Male
MH  - Metronidazole/*administration & dosage/adverse effects
MH  - Middle Aged
MH  - Prospective Studies
MH  - Rabeprazole
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2011/05/19 06:00
MHDA- 2011/08/31 06:00
CRDT- 2011/05/19 06:00
PHST- 2011/05/19 06:00 [entrez]
PHST- 2011/05/19 06:00 [pubmed]
PHST- 2011/08/31 06:00 [medline]
AID - 10.1111/j.1523-5378.2011.00842.x [doi]
PST - ppublish
SO  - Helicobacter. 2011 Jun;16(3):234-40. doi: 10.1111/j.1523-5378.2011.00842.x.


PMID- 21585548
OWN - NLM
STAT- MEDLINE
DCOM- 20120809
LR  - 20120417
IS  - 1399-0012 (Electronic)
IS  - 0902-0063 (Linking)
VI  - 26
IP  - 2
DP  - 2012 Mar-Apr
TI  - Are informed consent forms for organ transplantation and donation too difficult
      to read?
PG  - 275-83
LID - 10.1111/j.1399-0012.2011.01480.x [doi]
AB  - Informed consent for organ transplantation and donation is an ethical obligation,
      legally required, and considered as part of the Patient's Rights Condition of
      Medicare Participation for hospitals. National policy-makers recommend that
      informed consent forms and patient education materials be written at a low
      reading level (5th-8th grade level) to facilitate patient comprehension. We
      assessed reading levels of informed consent forms (CFs) for adult organ
      transplant recipients and living organ donors across US transplant centers. CFs
      were analyzed using three measures of reading level: Lexile Measure,
      Flesch-Kincaid Grade Level, and the Gunning Fog Index. Of active transplant
      centers contacted (N=209), 75 (36%) sent a total of 332 CFs. CFs were written, on
      average, at the college level, which is a considerably higher reading level than 
      the standards set by policy-makers. CF reading levels were negatively correlated 
      with transplant center volume (r=-0.119; p<0.03). CFs for intestine
      transplantation and for evaluation/listing were the easiest to read, while
      consent forms for liver transplantation/donation and pre-transplant agreements
      were the most difficult to read. Reducing CFs' reading level may help to increase
      patient comprehension for adequate informed consent.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Gordon, Elisa J
AU  - Gordon EJ
AD  - Department of Surgery, Comprehensive Transplant Center, Institute for Healthcare 
      Studies, Feinberg School of Medicine, Northwestern University, Chicago, IL
      60611-3152, USA. e-gordon@northwestern.edu
FAU - Bergeron, Ashley
AU  - Bergeron A
FAU - McNatt, Gwen
AU  - McNatt G
FAU - Friedewald, John
AU  - Friedewald J
FAU - Abecassis, Michael M
AU  - Abecassis MM
FAU - Wolf, Michael S
AU  - Wolf MS
LA  - eng
PT  - Journal Article
DEP - 20110517
PL  - Denmark
TA  - Clin Transplant
JT  - Clinical transplantation
JID - 8710240
SB  - IM
MH  - Comprehension
MH  - *Consent Forms
MH  - Humans
MH  - *Organ Transplantation
MH  - Reading
MH  - *Tissue and Organ Procurement
EDAT- 2011/05/19 06:00
MHDA- 2012/08/10 06:00
CRDT- 2011/05/19 06:00
PHST- 2011/05/19 06:00 [entrez]
PHST- 2011/05/19 06:00 [pubmed]
PHST- 2012/08/10 06:00 [medline]
AID - 10.1111/j.1399-0012.2011.01480.x [doi]
PST - ppublish
SO  - Clin Transplant. 2012 Mar-Apr;26(2):275-83. doi:
      10.1111/j.1399-0012.2011.01480.x. Epub 2011 May 17.


PMID- 21585406
OWN - NLM
STAT- MEDLINE
DCOM- 20111227
LR  - 20181201
IS  - 1472-765X (Electronic)
IS  - 0266-8254 (Linking)
VI  - 53
IP  - 2
DP  - 2011 Aug
TI  - Temperature dependency of Clostridium botulinum C and D toxin production from
      anaerobically enriched bovine gastrointestinal samples.
PG  - 174-7
LID - 10.1111/j.1472-765X.2011.03087.x [doi]
AB  - AIMS: To determine whether Clostridium botulinum neurotoxin (BoNT) production in 
      anaerobic culture was affected by temperature and could influence the sandwich
      ELISA (sELISA) detection of group III toxins in pre-enriched gastrointestinal
      (GI) contents from clinically suspect cattle botulism cases. METHODS AND RESULTS:
      Bovine post-mortem GI samples taken from 124 and 96 animals with suspect and
      nonsuspect botulism, respectively, were pre-enriched anaerobically at 30 and 37
      degrees C prior to testing by sELISA. After enrichment at 37 degrees C, BoNT was 
      demonstrated in all clinically suspect bovine botulism cases that had been
      identified by the mouse bioassay, and enrichment by both temperatures enabled
      BoNT detection in a number of mouse bioassay-negative suspect cases. CONCLUSIONS:
      Culture temperature does influence the production of group III BoNT, and
      incubation at both 30 and 37 degrees C is required for optimum detection.
      SIGNIFICANCE AND IMPACT OF THE STUDY: The in vitro assay defined in this study
      has the potential of improving the confirmation rate of clinically suspect cattle
      botulism cases whilst reducing the use of the costly and ethically sensitive
      mouse bioassay, the current diagnostic gold standard for BoNT testing.
CI  - (c) 2011 The Authors. Letters in Applied Microbiology (c) 2011 The Society for
      Applied Microbiology.
FAU - Brooks, C E
AU  - Brooks CE
AD  - Agri-Food and Biosciences Institute (AFBI), Veterinary Sciences Division (VSD),
      Stormont, Belfast, UK. cathy.brooks@afbini.gov.uk
FAU - Clarke, H J
AU  - Clarke HJ
FAU - Ardis, T C
AU  - Ardis TC
FAU - Ball, H J
AU  - Ball HJ
LA  - eng
PT  - Journal Article
DEP - 20110602
PL  - England
TA  - Lett Appl Microbiol
JT  - Letters in applied microbiology
JID - 8510094
RN  - 331HTW151K (botulinum toxin type D)
RN  - EC 3.4.24.69 (Botulinum Toxins)
RN  - FPM7829VMX (botulinum toxin type C)
SB  - IM
MH  - Anaerobiosis
MH  - Animals
MH  - Biological Assay
MH  - Body Temperature
MH  - Botulinum Toxins/*metabolism
MH  - Botulism/diagnosis/*veterinary
MH  - Cattle
MH  - Cattle Diseases/diagnosis
MH  - Clostridium botulinum type C/*metabolism
MH  - Clostridium botulinum type D/*metabolism
MH  - Enzyme-Linked Immunosorbent Assay/methods/veterinary
MH  - Gastrointestinal Contents/*microbiology
EDAT- 2011/05/19 06:00
MHDA- 2011/12/28 06:00
CRDT- 2011/05/19 06:00
PHST- 2011/05/19 06:00 [entrez]
PHST- 2011/05/19 06:00 [pubmed]
PHST- 2011/12/28 06:00 [medline]
AID - 10.1111/j.1472-765X.2011.03087.x [doi]
PST - ppublish
SO  - Lett Appl Microbiol. 2011 Aug;53(2):174-7. doi: 10.1111/j.1472-765X.2011.03087.x.
      Epub 2011 Jun 2.


PMID- 21585305
OWN - NLM
STAT- MEDLINE
DCOM- 20110901
LR  - 20110518
IS  - 1757-6199 (Electronic)
IS  - 1757-6180 (Linking)
VI  - 3
IP  - 10
DP  - 2011 May
TI  - Dried blood spot sampling: practical considerations and recommendation for use
      with preclinical studies.
PG  - 1099-107
LID - 10.4155/BIO.11.68 [doi]
AB  - At present it is necessary to use animals to generate toxicokinetic data as part 
      of preclinical safety studies. However, ethical standards require animal use to
      be carefully monitored and the principles of the 3Rs: replacement, reduction and 
      refinement, to be considered and applied. Use of dried blood spot (DBS) samples, 
      typically 10 to 20 microl, rather than the larger blood volumes required to
      obtain plasma samples, fully embraces the latter two principles of reduction and 
      refinement. The use of DBS sampling enables the number of rodents per study to be
      reduced whilst also refining the way blood samples are taken from both rodents
      and non-rodents. The recent changes to the European Directive on the protection
      of animals used for scientific purposes favor DBS sampling becoming the standard 
      for generation of toxicokinetic data, and imply that pharmaceutical companies
      will have to justify why plasma samples (and therefore larger blood volumes) are 
      required for bioanalysis. Use of DBS samples has been, and is being, discussed
      widely within the pharmaceutical industry as the move away from taking large
      blood volumes becomes inevitable.
FAU - Burnett, Josephine Ec
AU  - Burnett JE
AD  - Covance Laboratories Ltd, Harrogate, North Yorkshire, UK. jo.burnett@covance.com
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Bioanalysis
JT  - Bioanalysis
JID - 101512484
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Animals
MH  - Blood Specimen Collection/*methods
MH  - Blood Volume
MH  - Dogs
MH  - *Drug Evaluation, Preclinical
MH  - Female
MH  - Male
MH  - Mice
MH  - Pharmaceutical Preparations/blood
MH  - Pharmacokinetics
MH  - Rats
EDAT- 2011/05/19 06:00
MHDA- 2011/09/02 06:00
CRDT- 2011/05/19 06:00
PHST- 2011/05/19 06:00 [entrez]
PHST- 2011/05/19 06:00 [pubmed]
PHST- 2011/09/02 06:00 [medline]
AID - 10.4155/bio.11.68 [doi]
PST - ppublish
SO  - Bioanalysis. 2011 May;3(10):1099-107. doi: 10.4155/bio.11.68.


PMID- 21585181
OWN - NLM
STAT- MEDLINE
DCOM- 20110616
LR  - 20150901
IS  - 0350-199X (Linking)
VI  - 65
IP  - 2
DP  - 2011
TI  - Follow-up of acute aortic dissection.
PG  - 89-91
AB  - INTRODUCTION: Aortic dissection is a tear in the wall of the aorta. It is a
      medical emergency. If left untreated the mortality rate is extremely high. Aortic
      dissection is divided into two types, A and B. Primary, because of low suspicion 
      the diagnosis can delay. The natural history is poorly understood. OBJECTIVES:
      Our objectives were to improve diagnosis of aortic dissection. To encourage use
      of trans esophageal echo cardiography in emergency room. To clarify the role of
      prompt treatment in prognosis of aortic dissection. METHODS: This study was
      approved by the Committee of Ethics. All of the patients signed a informed
      consent. Clinical evaluation was performed by expert cardiologists, using
      different modalities. A complete medical history and physical examination were
      performed. The follow-up time of patients was 24 months. RESULTS: Eleven patients
      were included in this study. Male/female ratio was 2.7:1. Type A was present in 7
      patients, hypertension in 9. All patients were symptomatic. Three patients died, 
      two in the emergency center, one after surgery. Surgery was performed in five
      patients, all with type A dissection. Four survived patients after operation and 
      all patients with type B dissection survived follow-up time of 24 months.
      CONCLUSION: Most crucial step in aortic dissection diagnosis remain clinical
      suspicion. It should be confirmed rapidly since it is lifesaving. We want to
      emphasize that the trans esophageal echo cardiography is very useful exam to make
      the diagnosis which is the key for correct treatment and for follow-up. It must
      be widely available in the emergency centre.
FAU - Kamberi, Lulzim S
AU  - Kamberi LS
AD  - University Clinical Centre of Kosova, Prishtina, Kosova. lulzimkamberi@gmail.com
FAU - Gorani, Daut R
AU  - Gorani DR
FAU - Karabulut, Ahmet M
AU  - Karabulut AM
FAU - Beqiri, Arton I
AU  - Beqiri AI
FAU - Mustafai, Ardian I
AU  - Mustafai AI
LA  - eng
PT  - Journal Article
PL  - Bosnia and Herzegovina
TA  - Med Arh
JT  - Medicinski arhiv
JID - 0400722
SB  - IM
MH  - Aneurysm, Dissecting/mortality/pathology/*surgery
MH  - Aortic Aneurysm/mortality/pathology/*surgery
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Survival Rate
MH  - Treatment Outcome
EDAT- 2011/05/19 06:00
MHDA- 2011/06/17 06:00
CRDT- 2011/05/19 06:00
PHST- 2011/05/19 06:00 [entrez]
PHST- 2011/05/19 06:00 [pubmed]
PHST- 2011/06/17 06:00 [medline]
PST - ppublish
SO  - Med Arh. 2011;65(2):89-91.


PMID- 21584467
OWN - NLM
STAT- MEDLINE
DCOM- 20110929
LR  - 20190907
IS  - 1678-4561 (Electronic)
IS  - 1413-8123 (Linking)
VI  - 16
IP  - 4
DP  - 2011 Apr
TI  - [Rehabilitation, ethics and technique].
PG  - 2263-9
LID - S1413-81232011000400025 [pii]
AB  - This paper initially includes the presentation of some ideas on the deficiency
      and the process of rehabilitation, whereby the latter is defined in its
      "condition" as a process. A few differences in relation to the idea of a program 
      in the strict sense (defined as a fixed set of previously defined procedures or
      techniques) will be detected, as well as some ethical implications in the social,
      health or educational fields for professionals working with the disabled. Thus,
      the handling of the technique and the use of institutional measures will be
      discussed in this context, inasmuch as they are related to subjective and
      educational processes inherent to rehabilitation work. In so doing, we hope to
      contribute to a better understanding of the role pertaining to these
      professionals.
FAU - De Martini, Andre
AU  - De Martini A
AD  - Instituto de Psicologia, Universidade de Sao Paulo, Av. Prof. Mello Moraes 1721, 
      Cidade Universitaria, 05508-030 Sao Paulo SP, Brazil. martini.de@gmail.com
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Reabilitacao, etica e tecnica.
PL  - Brazil
TA  - Cien Saude Colet
JT  - Ciencia & saude coletiva
JID - 9713483
SB  - IM
MH  - Disabled Persons/*rehabilitation
MH  - Humans
MH  - Rehabilitation/ethics
EDAT- 2011/05/18 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/05/18 06:00
PHST- 2007/05/11 00:00 [received]
PHST- 2009/09/04 00:00 [accepted]
PHST- 2011/05/18 06:00 [entrez]
PHST- 2011/05/18 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - S1413-81232011000400025 [pii]
AID - 10.1590/s1413-81232011000400025 [doi]
PST - ppublish
SO  - Cien Saude Colet. 2011 Apr;16(4):2263-9. doi: 10.1590/s1413-81232011000400025.


PMID- 21584444
OWN - NLM
STAT- MEDLINE
DCOM- 20110929
LR  - 20190907
IS  - 1678-4561 (Electronic)
IS  - 1413-8123 (Linking)
VI  - 16
IP  - 4
DP  - 2011 Apr
TI  - [Bioethics and research into mental health].
PG  - 2035-44
LID - S1413-81232011000400002 [pii]
AB  - This article discusses research in the field of mental health, examining the
      ethical is sues involved and the use of Informed Consent. In order to achieve
      these objectives two main approaches were used: (1) a brief history of the
      different treatments and research with patients with mental illness or
      disability; (2) theoretical and conceptual analysis of the main problems
      concerning the mental health field, namely the notion of vulnerability,
      responsibility and autonomy and the use of placebo control groups. Two main
      questions prompted the reflection on whether the patient with a mental disorder
      can sign an Informed Consent, and whether the use of a placebo is acceptable. The
      existence of antagonistic and contradictory positions indicates that mental
      health research is hampered by biases that are difficult to overcome. Ethical
      investigation that may contribute to the healing of mental disorders should not
      however be overlooked merely because of the difficulties involved in its
      implementation. It must be borne in mind that changes occurring in the context of
      Psychiatric Reform in Brazil are gradually altering archaic concepts about what
      constitutes mental illness and how this group should be understood and treated.
FAU - Braz, Marlene
AU  - Braz M
AD  - Escola Nacional de Saude Publica Sergio Arouca, Fundacao Oswaldo Cruz, Rio de
      Janeiro, RJ, Brazil. braz@iff.fiocruz.br
FAU - Schramm, Fermin Roland
AU  - Schramm FR
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Bioetica e pesquisa em saude mental.
PL  - Brazil
TA  - Cien Saude Colet
JT  - Ciencia & saude coletiva
JID - 9713483
SB  - IM
CIN - Cien Saude Colet. 2011 Apr;16(4):2045-6; author reply 2048-9. PMID: 21735760
CIN - Cien Saude Colet. 2011 Apr;16(4):2046-8; author reply 2048-9. PMID: 21735761
MH  - *Bioethical Issues
MH  - Biomedical Research/*ethics
MH  - Humans
MH  - *Mental Disorders
MH  - Mental Health
EDAT- 2011/05/18 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/05/18 06:00
PHST- 2011/05/18 06:00 [entrez]
PHST- 2011/05/18 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - S1413-81232011000400002 [pii]
AID - 10.1590/s1413-81232011000400002 [doi]
PST - ppublish
SO  - Cien Saude Colet. 2011 Apr;16(4):2035-44. doi: 10.1590/s1413-81232011000400002.


PMID- 21584379
OWN - NLM
STAT- MEDLINE
DCOM- 20111004
LR  - 20190608
IS  - 1518-8345 (Electronic)
IS  - 0104-1169 (Linking)
VI  - 19
IP  - 2
DP  - 2011 Mar-Apr
TI  - Colonization of nursing professionals by Staphylococcus aureus.
PG  - 325-31
LID - S0104-11692011000200014 [pii]
AB  - This cross-sectional study aimed to investigate the presence of Staphylococcus
      aureus in the saliva of the nursing team of a teaching hospital in the interior
      of Sao Paulo State. Three saliva samples were collected from 351 individuals with
      an interval of two months between each collection. All ethical aspects were
      considered. In 867 (82.3%) cultures there was no identification of Staphylococcus
      aureus in the saliva, in 88 (17.7%) cultures Staphylococcus aureus was isolated, 
      26 (2.5%) of which were resistant to methicillin. The prevalence of professionals
      colonized by Staphylococcus aureus was 41.0% (144/351), of which 7.1% (25/351)
      were characterized as methicillin-resistant Staphylococcus aureus. Transient
      carriers represented 81.2% and persistent carriers 18.8%. Resistance to mupirocin
      was 73.1% of MRSA and 9.3% of MSSA. The results demonstrate that it is the nurse 
      and nursing technician that are the professional categories most susceptible to
      MRSA. Broader discussion on the thematic and interventions are needed.
FAU - de Moura, Josely Pinto
AU  - de Moura JP
AD  - Escola de Enfermagem de Ribeirao Preto, Universidade de Sao Paulo, SP, Brazil.
      jpmfonseca@uol.com.br
FAU - Pimenta, Fabiana Cristina
AU  - Pimenta FC
FAU - Hayashida, Miyeko
AU  - Hayashida M
FAU - Cruz, Elaine Drehmer de Almeida
AU  - Cruz ED
FAU - Canini, Silvia Rita Marin da Silva
AU  - Canini SR
FAU - Gir, Elucir
AU  - Gir E
LA  - eng
LA  - por
LA  - spa
PT  - Journal Article
PL  - Brazil
TA  - Rev Lat Am Enfermagem
JT  - Revista latino-americana de enfermagem
JID - 9420934
MH  - Adult
MH  - Carrier State/epidemiology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Methicillin-Resistant Staphylococcus aureus/isolation & purification
MH  - Microbial Sensitivity Tests
MH  - Middle Aged
MH  - *Nursing Staff, Hospital
MH  - Saliva/*microbiology
MH  - Staphylococcus aureus/drug effects/*isolation & purification
MH  - Young Adult
EDAT- 2011/05/18 06:00
MHDA- 2011/10/05 06:00
CRDT- 2011/05/18 06:00
PHST- 2009/12/07 00:00 [received]
PHST- 2010/10/04 00:00 [accepted]
PHST- 2011/05/18 06:00 [entrez]
PHST- 2011/05/18 06:00 [pubmed]
PHST- 2011/10/05 06:00 [medline]
AID - S0104-11692011000200014 [pii]
AID - 10.1590/s0104-11692011000200014 [doi]
PST - ppublish
SO  - Rev Lat Am Enfermagem. 2011 Mar-Apr;19(2):325-31. doi:
      10.1590/s0104-11692011000200014.


PMID- 21584177
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 2229-5488 (Electronic)
IS  - 2229-3485 (Linking)
VI  - 2
IP  - 1
DP  - 2011 Jan
TI  - Phase 0 clinical trials in oncology new drug development.
PG  - 13-22
LID - 10.4103/2229-3485.76285 [doi]
AB  - Research focus of pharmaceutical industry has expanded to a larger extent in last
      few decades putting many more new molecules, particularly targeted agents, for
      the clinical development. On the other hand, researchers are facing serious
      challenges due to high failure rates of new molecules in clinical studies. The
      United States Food and Drug Administration (FDA) in combination with academia and
      industry experts identified many factors responsible for failures of new
      molecules, and with a vision of taking traditional drug development model toward 
      an innovative paradigm shift, issued regulatory guidance on conduct of
      exploratory investigational new drug (exploratory IND) studies, often called as
      phase 0 clinical trials, requiring reduced preclinical testing, which has special
      relevance to life-threatening diseases such as cancer. Phase 0 trials, utilizing 
      much lower drug doses, provide an opportunity to explore the clinical behavior of
      new molecules very early in the drug development pathway, helping to identify the
      promising candidates and eliminating non-promising molecules, thus improving the 
      efficiency of overall drug development with significant savings of resources.
      Being non-therapeutic in nature, these studies, however, pose certain ethical
      challenges requiring careful study designing and informed consent process. This
      article reviews the insights and perspectives for the feasibility, utility,
      planning, designing and conduct of phase 0 clinical trials, in addition to
      ethical issues and industrial perspective focused at oncology new drug
      development.
FAU - Gupta, Umesh Chandra
AU  - Gupta UC
AD  - Clinical Research and Medical Services, Fresenius Kabi Oncology Ltd., Gurgaon,
      Delhi.
FAU - Bhatia, Sandeep
AU  - Bhatia S
FAU - Garg, Amit
AU  - Garg A
FAU - Sharma, Amit
AU  - Sharma A
FAU - Choudhary, Vaibhav
AU  - Choudhary V
LA  - eng
PT  - Journal Article
PL  - India
TA  - Perspect Clin Res
JT  - Perspectives in clinical research
JID - 101551517
PMC - PMC3088951
OTO - NOTNLM
OT  - Phase 0
OT  - clinical trials
OT  - exploratory investigational new drug
OT  - oncology
EDAT- 2011/05/18 06:00
MHDA- 2011/05/18 06:01
CRDT- 2011/05/18 06:00
PHST- 2011/05/18 06:00 [entrez]
PHST- 2011/05/18 06:00 [pubmed]
PHST- 2011/05/18 06:01 [medline]
AID - 10.4103/2229-3485.76285 [doi]
AID - PCR-2-13 [pii]
PST - ppublish
SO  - Perspect Clin Res. 2011 Jan;2(1):13-22. doi: 10.4103/2229-3485.76285.


PMID- 21584176
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 2229-5488 (Electronic)
IS  - 2229-3485 (Linking)
VI  - 2
IP  - 1
DP  - 2011 Jan
TI  - Challenges in conducting psychiatry studies in India.
PG  - 8-12
LID - 10.4103/2229-3485.76284 [doi]
AB  - A large number of psychiatry studies are conducted in India. Psychiatry studies
      are complex and present unique challenges in the Indian setting. Ethical issues
      pertaining to the risk of worsening of illness, use of placebo and validity of
      informed consents are commonly faced. Site selection can be difficult due to the 
      relative paucity of ICH-GCP (International Conference on Harmonisation - Good
      Clinical Practice) trained psychiatry investigators in India. Recruitment can be 
      challenging due to issues such as strict eligibility criteria, (lack of)
      availability of caregiver, illness-related considerations, etc. Assessment of the
      consent capacity of patients is not simple, while structured assessments are not 
      commonly employed. As the illness fluctuates, the consent capacity may change,
      thus requiring continued assessment of consent capacity. Study patients run the
      risk of worsening of illness and suicide due to exposure to inactive treatments; 
      this risk is counterbalanced by use of appropriate study designs, as well as the 
      indirect psychotherapeutic support received. Psychiatry studies are associated
      with a high placebo response. This necessitates conduct of placebo-controlled
      studies despite the attendant difficulties. Also, the high placebo response is
      often the cause of failed trials. Rating scales are essential for assessment of
      drug response. Some rating instruments as well as some rater training procedures 
      may not be suitable for the Indian setting. Technological advancements may
      increase the procedural complexity but improve the quality of ratings. Psychiatry
      studies present monitors and auditors with unique scenarios too. Utilization of
      psychiatry specific training and expertise is recommended to ensure successful
      conduct of these studies in India.
FAU - Kharawala, Saifuddin
AU  - Kharawala S
AD  - Clinical Research Consultant, Consultant Psychiatrist, GlaxoSmithKline
      Pharmaceuticals India Ltd., Mumbai, Maharashtra, India.
FAU - Dalal, Jeroze
AU  - Dalal J
LA  - eng
PT  - Journal Article
PL  - India
TA  - Perspect Clin Res
JT  - Perspectives in clinical research
JID - 101551517
PMC - PMC3088958
OTO - NOTNLM
OT  - Challenges
OT  - India
OT  - informed consent
OT  - placebo
OT  - psychiatry
OT  - rating
EDAT- 2011/05/18 06:00
MHDA- 2011/05/18 06:01
CRDT- 2011/05/18 06:00
PHST- 2011/05/18 06:00 [entrez]
PHST- 2011/05/18 06:00 [pubmed]
PHST- 2011/05/18 06:01 [medline]
AID - 10.4103/2229-3485.76284 [doi]
AID - PCR-2-8 [pii]
PST - ppublish
SO  - Perspect Clin Res. 2011 Jan;2(1):8-12. doi: 10.4103/2229-3485.76284.


PMID- 21584175
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 2229-5488 (Electronic)
IS  - 2229-3485 (Linking)
VI  - 2
IP  - 1
DP  - 2011 Jan
TI  - Patient advocacy groups: Need and opportunity in India.
PG  - 4-7
LID - 10.4103/2229-3485.76283 [doi]
AB  - With an increasing number of corporate hospitals, healthcare related issues,
      research trials and undue attention by media in India, there is a need to focus
      more on patient's rights and protection. In India, multiple agencies like
      regulatory bodies, scientific review committees, ethics committees, NGOs, etc.
      work toward patient rights and protection. However, these agencies are inadequate
      to cater to the general issues related to patient's rights. There's a need to
      have a separate group of people who provide advocacy to the patient, or simply, a
      patient advocacy group which will work explicitly in these areas to increase
      transparency and credibility of healthcare system in India. This group will
      provide special attention to patient care and protection of rights from the
      planning stage rather than at the troubleshooting stage.
FAU - Shah, Kunal
AU  - Shah K
AD  - Eisai Clinical Research Singapore Pvt. Ltd., Mumbai, India.
FAU - Garg, Sunil
AU  - Garg S
LA  - eng
PT  - Journal Article
PL  - India
TA  - Perspect Clin Res
JT  - Perspectives in clinical research
JID - 101551517
PMC - PMC3088956
OTO - NOTNLM
OT  - Healthcare providers
OT  - government
OT  - media
OT  - patient advocacy
OT  - research
EDAT- 2011/05/18 06:00
MHDA- 2011/05/18 06:01
CRDT- 2011/05/18 06:00
PHST- 2011/05/18 06:00 [entrez]
PHST- 2011/05/18 06:00 [pubmed]
PHST- 2011/05/18 06:01 [medline]
AID - 10.4103/2229-3485.76283 [doi]
AID - PCR-2-4 [pii]
PST - ppublish
SO  - Perspect Clin Res. 2011 Jan;2(1):4-7. doi: 10.4103/2229-3485.76283.


PMID- 21577312
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 2150-5349 (Electronic)
IS  - 2150-5349 (Linking)
VI  - 2
IP  - 2
DP  - 2011 Apr 6
TI  - Identifying the best therapy for chronic anal fissure.
PG  - 9-16
LID - 10.4292/wjgpt.v2.i2.9 [doi]
AB  - Chronic anal fissure (CAF) is a painful tear or crack which occurs in the
      anoderm. The optimal algorithm of therapy for CAF is still debated. Lateral
      internal sphincterotomy (LIS) is a surgical treatment, considered as the 'gold
      standard' therapy for CAF. It relieves CAF symptoms with a high rate of healing. 
      Chemical sphincterotomy (CS) with nitrates, calcium blockers or botulinum toxin
      (BTX) is safe, with the rapid relief of pain, mild side-effects and no risk of
      surgery or anesthesia, but is a statistically less effective therapy for CAF than
      LIS. This article considers if aggressive treatment should only be offered to
      patients who fail pharmacological sphincterotomy. Aspects of anal fissure
      etiology, epidemiology and pathophysiology are considered with their meaning for 
      further management of CAF. A molecular model of chemical interdependence
      significant for the chemistry of CAF healing is examined. Its application may
      influence the development of optimal therapy for CAF. BTX is currently considered
      the most effective type of CS and discussion in this article scrutinizes this
      method specifically. Although the effectiveness of BTX vs. LIS has been
      discussed, the essential focus of the article concerns identifying the best
      therapy application for anal fissure. Elements are presented which may help us to
      predict CAF healing. They provide rationale for the expansion of the CAF therapy 
      algorithm. Ethical and economic factors are also considered in brief. As long as 
      the patient is willing to accept the potential risk of fecal incontinence, we
      have grounds for the 'gold standard' (LIS) as the first-line treatment for CAF.
      The author concludes that, when the diagnosis of the anal fissure is established,
      CS should be considered for both ethical and economic reasons. He is convinced
      that a greater understanding and recognition of benign anal disorders by the GP
      and a proactive involvement at the point of initial diagnosis would facilitate
      the consideration of CS at an earlier, more practical stage with improved
      outcomes for the patient.
FAU - Madalinski, Mariusz H
AU  - Madalinski MH
AD  - Mariusz H Madalinski, NHS Lothian-University Hospitals Division, Edinburgh EH4
      2XU, United Kingdom.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Gastrointest Pharmacol Ther
JT  - World journal of gastrointestinal pharmacology and therapeutics
JID - 101547456
PMC - PMC3091162
OTO - NOTNLM
OT  - Anal fissure
OT  - Benign anal diseases
OT  - Botulinum toxin
OT  - Chemical sphincterotomy
OT  - Ethics
OT  - Fissurectomy
OT  - Lateral internal sphincterotomy
OT  - Teaching
EDAT- 2011/05/18 06:00
MHDA- 2011/05/18 06:01
CRDT- 2011/05/18 06:00
PHST- 2010/07/17 00:00 [received]
PHST- 2011/03/20 00:00 [revised]
PHST- 2011/03/28 00:00 [accepted]
PHST- 2011/05/18 06:00 [entrez]
PHST- 2011/05/18 06:00 [pubmed]
PHST- 2011/05/18 06:01 [medline]
AID - 10.4292/wjgpt.v2.i2.9 [doi]
PST - ppublish
SO  - World J Gastrointest Pharmacol Ther. 2011 Apr 6;2(2):9-16. doi:
      10.4292/wjgpt.v2.i2.9.


PMID- 21577266
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20220311
IS  - 1662-5145 (Electronic)
IS  - 1662-5145 (Linking)
VI  - 5
DP  - 2011
TI  - DBS Makes You Feel Good! - Why Some of the Ethical Objections to the Use of DBS
      for Neuropsychiatric Disorders and Enhancement are Not Convincing.
PG  - 14
LID - 10.3389/fnint.2011.00014 [doi]
FAU - Pacholczyk, Anna
AU  - Pacholczyk A
AD  - Institute for Science, Ethics and Innovation, School of Law, University of
      Manchester Manchester, UK.
LA  - eng
PT  - Journal Article
DEP - 20110506
PL  - Switzerland
TA  - Front Integr Neurosci
JT  - Frontiers in integrative neuroscience
JID - 101477950
PMC - PMC3090675
EDAT- 2011/05/18 06:00
MHDA- 2011/05/18 06:01
CRDT- 2011/05/18 06:00
PHST- 2011/01/08 00:00 [received]
PHST- 2011/04/18 00:00 [accepted]
PHST- 2011/05/18 06:00 [entrez]
PHST- 2011/05/18 06:00 [pubmed]
PHST- 2011/05/18 06:01 [medline]
AID - 10.3389/fnint.2011.00014 [doi]
PST - epublish
SO  - Front Integr Neurosci. 2011 May 6;5:14. doi: 10.3389/fnint.2011.00014.
      eCollection 2011.


PMID- 21577250
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1662-5145 (Electronic)
IS  - 1662-5145 (Linking)
VI  - 5
DP  - 2011
TI  - Balancing the brain: resting state networks and deep brain stimulation.
PG  - 8
LID - 10.3389/fnint.2011.00008 [doi]
AB  - Over the last three decades, large numbers of patients with otherwise
      treatment-resistant disorders have been helped by deep brain stimulation (DBS),
      yet a full scientific understanding of the underlying neural mechanisms is still 
      missing. We have previously proposed that efficacious DBS works by restoring the 
      balance of the brain's resting state networks. Here, we extend this proposal by
      reviewing how detailed investigations of the highly coherent functional and
      structural brain networks in health and disease (such as Parkinson's) have the
      potential not only to increase our understanding of fundamental brain function
      but of how best to modulate the balance. In particular, some of the newly
      identified hubs and connectors within and between resting state networks could
      become important new targets for DBS, including potentially in neuropsychiatric
      disorders. At the same time, it is of essence to consider the ethical
      implications of this perspective.
FAU - Kringelbach, Morten L
AU  - Kringelbach ML
AD  - Department of Psychiatry, Warneford Hospital, University of Oxford Oxford, UK.
FAU - Green, Alexander L
AU  - Green AL
FAU - Aziz, Tipu Z
AU  - Aziz TZ
LA  - eng
PT  - Journal Article
DEP - 20110502
PL  - Switzerland
TA  - Front Integr Neurosci
JT  - Frontiers in integrative neuroscience
JID - 101477950
PMC - PMC3088866
OTO - NOTNLM
OT  - affective disorders
OT  - movement disorders
OT  - oscillations
OT  - resting state networks
OT  - spontaneous activity
EDAT- 2011/05/18 06:00
MHDA- 2011/05/18 06:01
CRDT- 2011/05/18 06:00
PHST- 2011/01/01 00:00 [received]
PHST- 2011/04/18 00:00 [accepted]
PHST- 2011/05/18 06:00 [entrez]
PHST- 2011/05/18 06:00 [pubmed]
PHST- 2011/05/18 06:01 [medline]
AID - 10.3389/fnint.2011.00008 [doi]
PST - epublish
SO  - Front Integr Neurosci. 2011 May 2;5:8. doi: 10.3389/fnint.2011.00008. eCollection
      2011.


PMID- 21577107
OWN - NLM
STAT- MEDLINE
DCOM- 20111017
LR  - 20130118
IS  - 1473-6551 (Electronic)
IS  - 1350-7540 (Linking)
VI  - 24
IP  - 4
DP  - 2011 Aug
TI  - Measuring the fading consciousness in the human brain.
PG  - 394-400
LID - 10.1097/WCO.0b013e328347da94 [doi]
AB  - PURPOSE OF REVIEW: Recent neuroimaging studies have provided novel insights on
      residual brain function in patients with disorders of consciousness, but also
      raised a number of ethical issues concerning the clinical management of these
      patients. RECENT FINDINGS: Clinical studies have rated the Coma Recovery Scale as
      the most appropriate scale to accurately differentiate patients in a vegetative
      state from patients in a minimally conscious state. At the population level, a
      number of neuroimaging studies have provided evidence for more preserved brain
      activity patterns and cerebral tissue integrity in minimally conscious as
      compared to vegetative-state patients. However, the use of neuroimaging
      techniques to diagnose consciousness at the single-patient level remains
      challenging. In particular, it has been shown that whereas command-following
      functional MRI paradigms may sometimes detect residual awareness in patients that
      are behaviorally unresponsive, they can also produce negative results in patients
      that are communicative at the bedside. SUMMARY: There is an urgent need of
      validation of functional MRI active paradigms on larger patient populations
      before they can be used in clinical routine. Further research on neural
      correlates of consciousness should hopefully allow using passive paradigms to
      assess the patients' conscious state without requiring their active
      collaboration.
FAU - Boly, Melanie
AU  - Boly M
AD  - Coma Science Group, Cyclotron Research Centre and Neurology Department,
      University of Liege and CHU Sart Tilman Hospital, Liege, Belgium. mboly@ulg.ac.be
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Curr Opin Neurol
JT  - Current opinion in neurology
JID - 9319162
SB  - IM
MH  - Awareness
MH  - Brain/*physiology/*physiopathology
MH  - Brain Mapping
MH  - Consciousness/*physiology
MH  - Consciousness Disorders/diagnosis/*physiopathology
MH  - Diagnostic Imaging/methods
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Persistent Vegetative State/diagnosis/physiopathology
EDAT- 2011/05/18 06:00
MHDA- 2011/10/18 06:00
CRDT- 2011/05/18 06:00
PHST- 2011/05/18 06:00 [entrez]
PHST- 2011/05/18 06:00 [pubmed]
PHST- 2011/10/18 06:00 [medline]
AID - 10.1097/WCO.0b013e328347da94 [doi]
PST - ppublish
SO  - Curr Opin Neurol. 2011 Aug;24(4):394-400. doi: 10.1097/WCO.0b013e328347da94.


PMID- 21576671
OWN - NLM
STAT- MEDLINE
DCOM- 20111013
LR  - 20181201
IS  - 1538-3660 (Electronic)
IS  - 1521-2491 (Linking)
VI  - 13
IP  - 3
DP  - 2011 May-Jun
TI  - Ethical behavior and the practice of medicine.
PG  - 214
LID - 10.1001/archfacial.2011.21 [doi]
FAU - Holt, G Richard
AU  - Holt GR
AD  - Center for Medical Humanities and Ethics, The University of Texas Health Science 
      Center, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA. holtg@uthscsa.edu
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Arch Facial Plast Surg
JT  - Archives of facial plastic surgery
JID - 100883500
SB  - IM
CON - Arch Facial Plast Surg. 2011 May-Jun;13(3):211-3. PMID: 21576669
MH  - *Bioethical Issues
MH  - *Ethics, Medical
EDAT- 2011/05/18 06:00
MHDA- 2011/10/14 06:00
CRDT- 2011/05/18 06:00
PHST- 2011/05/18 06:00 [entrez]
PHST- 2011/05/18 06:00 [pubmed]
PHST- 2011/10/14 06:00 [medline]
AID - 13/3/214 [pii]
AID - 10.1001/archfacial.2011.21 [doi]
PST - ppublish
SO  - Arch Facial Plast Surg. 2011 May-Jun;13(3):214. doi: 10.1001/archfacial.2011.21.


PMID- 21576669
OWN - NLM
STAT- MEDLINE
DCOM- 20111013
LR  - 20120924
IS  - 1538-3660 (Electronic)
IS  - 1521-2491 (Linking)
VI  - 13
IP  - 3
DP  - 2011 May-Jun
TI  - Are you ethical?: that may depend on who you are asking.
PG  - 211-3
LID - 10.1001/archfacial.2011.19 [doi]
AB  - Last week, I was stopped at a red light on a 2-lane street with construction
      barriers on both sides of my lane. Behind me, approaching fast, was an ambulance 
      with its siren wailing. In the oncoming lane, also stopped at the red light, was 
      a police car. Since I could not pull off to the right because of the barrier, my 
      only choice to get out of the path of the ambulance was to drive into the
      intersection despite the red light. However, if I did, I would be breaking the
      law in clear view of a police officer. But if I did not let the ambulance
      through, I would be violating an ethical norm. After quickly thinking through my 
      options, I made a judgment call and did what I thought best. What would you do?
FAU - Dayan, Steve
AU  - Dayan S
AD  - Division of Facial Plastic and Reconstructive Surgery, Department of
      Otolaryngology, University of Illinois at Chicago, 845 N Michigan Ave, Ste 923 E,
      Chicago, IL 60611, USA. sdayan@drdayan.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Arch Facial Plast Surg
JT  - Archives of facial plastic surgery
JID - 100883500
SB  - IM
CIN - Arch Facial Plast Surg. 2011 May-Jun;13(3):214. PMID: 21576671
MH  - *Bioethical Issues
MH  - Choice Behavior/ethics
MH  - *Ethics, Medical
MH  - Government Regulation
MH  - Judgment/ethics
MH  - United States
EDAT- 2011/05/18 06:00
MHDA- 2011/10/14 06:00
CRDT- 2011/05/18 06:00
PHST- 2011/05/18 06:00 [entrez]
PHST- 2011/05/18 06:00 [pubmed]
PHST- 2011/10/14 06:00 [medline]
AID - 13/3/211 [pii]
AID - 10.1001/archfacial.2011.19 [doi]
PST - ppublish
SO  - Arch Facial Plast Surg. 2011 May-Jun;13(3):211-3. doi:
      10.1001/archfacial.2011.19.


PMID- 21576191
OWN - NLM
STAT- MEDLINE
DCOM- 20121101
LR  - 20151119
IS  - 1525-1489 (Electronic)
IS  - 0885-0666 (Linking)
VI  - 27
IP  - 4
DP  - 2012 Jul-Aug
TI  - Consent for donation after cardiac death: a survey of organ procurement
      organizations.
PG  - 253-63
LID - 10.1177/0885066610397110 [doi]
AB  - CONTEXT: Despite the increasing number of policies governing organ donation after
      cardiac death (DCD), nothing is presently known about the informed consent
      process for DCD. Without guidelines, organ procurement organizations (OPOs) are
      likely to structure the consent process similarly to that for organ donation
      after brain death (DBD), despite important ethical differences between the 2
      modes of organ recovery. OBJECTIVE: To describe informed consent practices used
      by OPOs for DCD. DESIGN, SETTING, AND PARTICIPANTS: Cross-sectional,
      internet-based survey of the 58 OPOs in the United States. MAIN OUTCOME MEASURES:
      OPO policies and reported levels of physician participation in the consent
      process for DCD. RESULTS: Seventeen OPOs completed the survey (29%). Responders
      and nonresponders did not differ by DCD volume over the last year or last 5
      years. None of the OPO's policies require physician involvement in obtaining
      written informed consent; 94% of policies require only the OPO representative to 
      obtain written consent for DCD and 6% state that either the OPO representative or
      the treating physician may obtain consent; 71% of OPOs reported that discussions 
      with family regarding DCD occur with the treating physician present less than 51%
      of the time and 82% indicated that the OPO representative is solely involved in
      obtaining consent for DCD in the majority of cases. A total of 24% of OPOs
      require physicians to participate in obtaining consent for procedures performed
      prior to death exclusively for organ preservation. No differences were found
      between the OPO consent practices for DCD and DBD. CONCLUSIONS: None of the OPOs 
      responding to this survey have a policy requirement for physician involvement in 
      obtaining consent for DCD. These findings raise questions about the role of
      physicians in DCD and how best to maintain a patient- and family-centered focus
      on care for patients at the end of life while supporting organ recovery efforts.
FAU - Kalkbrenner, Kathy J
AU  - Kalkbrenner KJ
AD  - Center for Bioethics, Columbia University College of Physicians and Surgeons, New
      York, NY, USA. kjkalkbrenner@gmail.com
FAU - Hardart, George E
AU  - Hardart GE
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20110516
PL  - United States
TA  - J Intensive Care Med
JT  - Journal of intensive care medicine
JID - 8610344
SB  - IM
MH  - Brain Death/diagnosis
MH  - Cross-Sectional Studies
MH  - *Death
MH  - Health Surveys
MH  - Humans
MH  - Informed Consent/*standards
MH  - Organ Preservation
MH  - *Organizational Policy
MH  - *Practice Guidelines as Topic
MH  - *Practice Patterns, Physicians'
MH  - *Professional-Family Relations
MH  - Surveys and Questionnaires
MH  - Tissue and Organ Procurement/*organization & administration/standards
MH  - United States
EDAT- 2011/05/18 06:00
MHDA- 2012/11/02 06:00
CRDT- 2011/05/18 06:00
PHST- 2011/05/18 06:00 [entrez]
PHST- 2011/05/18 06:00 [pubmed]
PHST- 2012/11/02 06:00 [medline]
AID - 0885066610397110 [pii]
AID - 10.1177/0885066610397110 [doi]
PST - ppublish
SO  - J Intensive Care Med. 2012 Jul-Aug;27(4):253-63. doi: 10.1177/0885066610397110.
      Epub 2011 May 16.


PMID- 21576148
OWN - NLM
STAT- MEDLINE
DCOM- 20110913
LR  - 20211020
IS  - 1471-2970 (Electronic)
IS  - 0962-8436 (Linking)
VI  - 366
IP  - 1572
DP  - 2011 Jun 27
TI  - Placebo interventions, placebo effects and clinical practice.
PG  - 1905-12
LID - 10.1098/rstb.2010.0383 [doi]
AB  - This article reviews the role of placebo interventions and placebo effects in
      clinical practice. We first describe the relevance of different perspectives
      among scientists, physicians and patients on what is considered a placebo
      intervention in clinical practice. We then summarize how placebo effects have
      been investigated in randomized controlled trials under the questionable premise 
      that such effects are produced by placebo interventions. We further discuss why a
      shift of focus from the placebo intervention to the overall therapeutic context
      is necessary and what research methods can be used for the clinical investigation
      of the relevance of context effects. In the last part of the manuscript, we
      discuss why placebo or context effects are seen as positive in clinical practice 
      when they are associated with active treatments, while placebo interventions pose
      major ethical and professional problems and have to be avoided.
FAU - Linde, Klaus
AU  - Linde K
AD  - Institute of General Practice, Technische Universitat Munchen, 81667 Munich,
      Germany. klaus.linde@lrz.tum.de
FAU - Fassler, Margrit
AU  - Fassler M
FAU - Meissner, Karin
AU  - Meissner K
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Philos Trans R Soc Lond B Biol Sci
JT  - Philosophical transactions of the Royal Society of London. Series B, Biological
      sciences
JID - 7503623
SB  - IM
MH  - Clinical Medicine/*methods
MH  - Humans
MH  - *Placebo Effect
MH  - Randomized Controlled Trials as Topic/ethics/methods
MH  - Research Design
PMC - PMC3130396
EDAT- 2011/05/18 06:00
MHDA- 2011/09/14 06:00
CRDT- 2011/05/18 06:00
PHST- 2011/05/18 06:00 [entrez]
PHST- 2011/05/18 06:00 [pubmed]
PHST- 2011/09/14 06:00 [medline]
AID - 366/1572/1905 [pii]
AID - 10.1098/rstb.2010.0383 [doi]
PST - ppublish
SO  - Philos Trans R Soc Lond B Biol Sci. 2011 Jun 27;366(1572):1905-12. doi:
      10.1098/rstb.2010.0383.


PMID- 21576147
OWN - NLM
STAT- MEDLINE
DCOM- 20110913
LR  - 20220317
IS  - 1471-2970 (Electronic)
IS  - 0962-8436 (Linking)
VI  - 366
IP  - 1572
DP  - 2011 Jun 27
TI  - Reframing placebo in research and practice.
PG  - 1896-904
LID - 10.1098/rstb.2010.0405 [doi]
AB  - The terms 'placebo' and 'placebo effects' cause confusion among patients,
      practitioners and scientists. This confusion results in both the adoption of
      practices that have no evidence of specificity yet considerable risk (such as
      surgery for low back pain) or the elimination of clinical practices proven to
      facilitate healing because they are not 'better than placebo' (such as
      acupuncture for low back pain). In this article, I discuss these issues and
      introduce the concept of optimal healing environment as a framework for
      disentangling what is useful from placebo research for adopting into clinical
      practice in a manner that is ethical and evidence-based.
FAU - Jonas, Wayne B
AU  - Jonas WB
AD  - Samueli Institute, 1737 King Street, Suite 600, Alexandria, VA 22314, USA.
      wjonas@siib.org
LA  - eng
PT  - Journal Article
PL  - England
TA  - Philos Trans R Soc Lond B Biol Sci
JT  - Philosophical transactions of the Royal Society of London. Series B, Biological
      sciences
JID - 7503623
SB  - IM
MH  - Clinical Medicine/*methods
MH  - Clinical Trials as Topic
MH  - Evidence-Based Medicine
MH  - Humans
MH  - Learning
MH  - *Placebo Effect
MH  - *Research Design
MH  - Social Behavior
PMC - PMC3130408
EDAT- 2011/05/18 06:00
MHDA- 2011/09/14 06:00
CRDT- 2011/05/18 06:00
PHST- 2011/05/18 06:00 [entrez]
PHST- 2011/05/18 06:00 [pubmed]
PHST- 2011/09/14 06:00 [medline]
AID - 366/1572/1896 [pii]
AID - 10.1098/rstb.2010.0405 [doi]
PST - ppublish
SO  - Philos Trans R Soc Lond B Biol Sci. 2011 Jun 27;366(1572):1896-904. doi:
      10.1098/rstb.2010.0405.


PMID- 21575837
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20110517
IS  - 1558-0776 (Electronic)
IS  - 1071-9091 (Linking)
VI  - 18
IP  - 1
DP  - 2011 Mar
TI  - Evidence-based neuroethics for neurodevelopmental disorders.
PG  - 21-5
LID - 10.1016/j.spen.2011.02.002 [doi]
AB  - Many neurodevelopmental disorders affect early brain development in ways that are
      still poorly understood; yet, these disorders can place an enormous toll on
      patients, families, and society as a whole and affect all aspects of daily living
      for patients and their families. We describe a pragmatic, evidence-based
      framework for engaging in empiric ethics inquiry for a large consortium of
      researchers in neurodevelopmental disorders and provide relevant case studies of 
      pragmatic neuroethics. The 3 neurodevelopmental disorders that are at the focus
      of our research, cerebral palsy (CP), autism spectrum disorder (ASD), and fetal
      alcohol spectrum disorder (FASD), bring unique and intersecting challenges of
      translating ethically research into clinical care for children and neonates. We
      identify and discuss challenges related to health care delivery in CP; neonatal
      neurological decision making; alternative therapies; and identity, integrity, and
      personhood.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Racine, Eric
AU  - Racine E
AD  - Neuroethics Research Unit, Institut de recherches cliniques de Montreal,
      Montreal, Quebec, Canada. eric.racine@ircm.qc.ca
FAU - Bell, Emily
AU  - Bell E
FAU - Di Pietro, Nina C
AU  - Di Pietro NC
FAU - Wade, Lucie
AU  - Wade L
FAU - Illes, Judy
AU  - Illes J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Semin Pediatr Neurol
JT  - Seminars in pediatric neurology
JID - 9441351
SB  - IM
MH  - *Bioethical Issues
MH  - *Brain Diseases
MH  - Canada
MH  - Government Programs/*organization & administration
MH  - Humans
EDAT- 2011/05/18 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/05/18 06:00
PHST- 2011/05/18 06:00 [entrez]
PHST- 2011/05/18 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - S1071-9091(11)00003-9 [pii]
AID - 10.1016/j.spen.2011.02.002 [doi]
PST - ppublish
SO  - Semin Pediatr Neurol. 2011 Mar;18(1):21-5. doi: 10.1016/j.spen.2011.02.002.


PMID- 21575218
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1752-1505 (Electronic)
IS  - 1752-1505 (Linking)
VI  - 5
DP  - 2011 May 16
TI  - Public health equity in refugee situations.
PG  - 6
LID - 10.1186/1752-1505-5-6 [doi]
AB  - Addressing increasing concerns about public health equity in the context of
      violent conflict and the consequent forced displacement of populations is
      complex. Important operational questions now faced by humanitarian agencies can
      to some extent be clarified by reference to relevant ethical theory. Priorities
      of service delivery, the allocation choices, and the processes by which they are 
      arrived at are now coming under renewed scrutiny in the light of the estimated
      two million refugees who fled from Iraq since 2003.Operational questions that
      need to be addressed include health as a relative priority, allocations between
      and within different populations, and transition and exit strategies. Public
      health equity issues faced by the humanitarian community can be framed as issues 
      of resource allocation and issues of decision-making. The ethical approach to
      resource allocation in health requires taking adequate steps to reduce suffering 
      and promote wellbeing, with the upper bound being to avoid harming those at the
      lower end of the welfare continuum. Deliberations in the realm of international
      justice have not provided a legal or implementation platform for reducing health 
      disparities across the world, although norms and expectations, including within
      the humanitarian community, may be moving in that direction.Despite the
      limitations of applying ethical theory in the fluid, complex and highly political
      environment of refugee settings, this article explores how this theory could be
      used in these contexts and provides practical examples. The intent is to
      encourage professionals in the field, such as aid workers, health care providers,
      policy makers, and academics, to consider these ethical principles when making
      decisions.
FAU - Leaning, Jennifer
AU  - Leaning J
AD  - FXB Center for Health and Human Rights, Harvard School of Public Health, Boston, 
      MA, USA. jleaning@hsph.harvard.edu.
FAU - Spiegel, Paul
AU  - Spiegel P
FAU - Crisp, Jeff
AU  - Crisp J
LA  - eng
PT  - Journal Article
DEP - 20110516
PL  - England
TA  - Confl Health
JT  - Conflict and health
JID - 101286573
PMC - PMC3117691
EDAT- 2011/05/18 06:00
MHDA- 2011/05/18 06:01
CRDT- 2011/05/18 06:00
PHST- 2010/10/19 00:00 [received]
PHST- 2011/05/16 00:00 [accepted]
PHST- 2011/05/18 06:00 [entrez]
PHST- 2011/05/18 06:00 [pubmed]
PHST- 2011/05/18 06:01 [medline]
AID - 1752-1505-5-6 [pii]
AID - 10.1186/1752-1505-5-6 [doi]
PST - epublish
SO  - Confl Health. 2011 May 16;5:6. doi: 10.1186/1752-1505-5-6.


PMID- 21574790
OWN - NLM
STAT- MEDLINE
DCOM- 20110923
LR  - 20220330
IS  - 1360-0567 (Electronic)
IS  - 0963-8237 (Linking)
VI  - 20
IP  - 3
DP  - 2011 Jun
TI  - Perceptions of involuntary admission and risk of subsequent readmission at
      one-year follow-up: the influence of insight and recovery style.
PG  - 249-59
LID - 10.3109/09638237.2011.562263 [doi]
AB  - BACKGROUND: Involuntary admission is one of the most ethically challenging
      practices in medicine, yet we are only beginning to learn more about the
      patient's perspective. AIMS: To investigate (i) peoples' perception of the
      necessity of their involuntary admission at one year after discharge (ii)
      readmission rates to hospital and the influence of insight and recovery style.
      METHODS: We interviewed individuals admitted involuntarily at one year following 
      discharge using the Mac Arthur Admission Experience Interview, Birchwood Insight 
      Scale, the Drug Attitude Inventory, Global Assessment of Functioning and the
      Recovery Style Questionnaire. RESULTS: Sixty-eight people (84%) were
      re-interviewed at one year and fewer (60%) reported that their involuntary
      admission had been necessary when compared to inception (72%). Of the 33% that
      changed their views, most reflected negatively on their involuntary admission. We
      found that insight was moderately associated with the acknowledgement that the
      involuntary admission was necessary. Within a year, 43% were readmitted to
      hospital and half of these admissions were involuntary. Individuals with a
      sealing over recovery style were at four times the risk of involuntary
      readmission. CONCLUSIONS: Peoples' perception of the necessity of their
      involuntary admissions is not stable over time and risk of involuntary
      readmission is associated with recovery style.
FAU - O'Donoghue, Brian
AU  - O'Donoghue B
AD  - St John of God/ St Vincents University Hospital Postgraduate Training Scheme in
      Psychiatry, Dublin, Ireland. briannoelodonoghue@gmail.com
FAU - Lyne, John
AU  - Lyne J
FAU - Hill, Michele
AU  - Hill M
FAU - O'Rourke, Linda
AU  - O'Rourke L
FAU - Daly, Sally
AU  - Daly S
FAU - Larkin, Conall
AU  - Larkin C
FAU - Feeney, Larkin
AU  - Feeney L
FAU - O'Callaghan, Eadbhard
AU  - O'Callaghan E
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Ment Health
JT  - Journal of mental health (Abingdon, England)
JID - 9212352
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Awareness
MH  - *Commitment of Mentally Ill
MH  - Female
MH  - Humans
MH  - Ireland
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - *Patient Readmission
MH  - *Patient Satisfaction
MH  - Psychotic Disorders/psychology/*rehabilitation
MH  - Retrospective Studies
EDAT- 2011/05/18 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/05/18 06:00
PHST- 2011/05/18 06:00 [entrez]
PHST- 2011/05/18 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 10.3109/09638237.2011.562263 [doi]
PST - ppublish
SO  - J Ment Health. 2011 Jun;20(3):249-59. doi: 10.3109/09638237.2011.562263.


PMID- 21574413
OWN - NLM
STAT- MEDLINE
DCOM- 20110519
LR  - 20110516
IS  - 0023-7205 (Print)
IS  - 0023-7205 (Linking)
VI  - 108
IP  - 13
DP  - 2011 Mar 30-Apr 5
TI  - [Social media change the professional-patient relation. Clarification of ethical 
      guidelines concerning social networking on the Internet is necessary].
PG  - 727-9
FAU - Chenik, Marie
AU  - Chenik M
AD  - Karolinska universitetssjukhuset, Stockholm. marie.chenik@karolinska.se
FAU - Bolinder, Gunilla
AU  - Bolinder G
FAU - Juth, Niklas
AU  - Juth N
LA  - swe
PT  - Journal Article
TT  - Sociala medier forandrar relationen mellan patient och vardgivare. Tydligare
      etiska riktlinjer behovs i umganget pa Internet.
PL  - Sweden
TA  - Lakartidningen
JT  - Lakartidningen
JID - 0027707
SB  - IM
MH  - Blogging/ethics
MH  - Communication
MH  - Confidentiality/ethics
MH  - Guidelines as Topic
MH  - Humans
MH  - Internet/*ethics
MH  - Nurse-Patient Relations/ethics
MH  - Physician-Patient Relations
MH  - Professional-Patient Relations/*ethics
EDAT- 2011/05/18 06:00
MHDA- 2011/05/20 06:00
CRDT- 2011/05/18 06:00
PHST- 2011/05/18 06:00 [entrez]
PHST- 2011/05/18 06:00 [pubmed]
PHST- 2011/05/20 06:00 [medline]
PST - ppublish
SO  - Lakartidningen. 2011 Mar 30-Apr 5;108(13):727-9.


PMID- 21574320
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20110516
IS  - 0038-0814 (Print)
IS  - 0038-0814 (Linking)
IP  - 754
DP  - 2011 Apr
TI  - [Ethical questioning in the social and medical-social sector, a recommendation].
PG  - 55
FAU - Hervy, Marie-Pierre
AU  - Hervy MP
AD  - Agence nationale de I'evaluation et de la qualite des etablissements et services 
      sociaux et medico-sociaux. Marie-Pierre.Hervy@sante.gouv.fr
FAU - Lallemand, Dominique
AU  - Lallemand D
LA  - fre
PT  - Journal Article
TT  - Le questionnement ethique dans le secteur social et medico-social, une
      recommandation.
PL  - France
TA  - Soins
JT  - Soins; la revue de reference infirmiere
JID - 20910580R
MH  - Guidelines as Topic
MH  - Health Services/*ethics
MH  - Social Work/*ethics
EDAT- 2011/05/18 06:00
MHDA- 2011/06/29 06:00
CRDT- 2011/05/18 06:00
PHST- 2011/05/18 06:00 [entrez]
PHST- 2011/05/18 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
PST - ppublish
SO  - Soins. 2011 Apr;(754):55.


PMID- 21574319
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20110516
IS  - 0038-0814 (Print)
IS  - 0038-0814 (Linking)
IP  - 754
DP  - 2011 Apr
TI  - [Interdisciplinary teaching of ethical questioning].
PG  - 53-4
AB  - Interdisciplinary teaching of ethics has been developed at the university
      hospital of Besancon for students in various healthcare fields. The aim is to
      give future healthcare professionals a better understanding of the collegiality
      required to undertake, in a work situation, good quality ethical reflection.
FAU - Aubry, Regis
AU  - Aubry R
AD  - Centre Hospitalier Universitaire, Besancon. Raubry@chu-besancon.fr
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Un enseignement interdisciplinaire sur le questionnement ethique.
PL  - France
TA  - Soins
JT  - Soins; la revue de reference infirmiere
JID - 20910580R
MH  - *Ethics
MH  - Health Personnel/*education
EDAT- 2011/05/18 06:00
MHDA- 2011/06/29 06:00
CRDT- 2011/05/18 06:00
PHST- 2011/05/18 06:00 [entrez]
PHST- 2011/05/18 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
PST - ppublish
SO  - Soins. 2011 Apr;(754):53-4.


PMID- 21574318
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20110516
IS  - 0038-0814 (Print)
IS  - 0038-0814 (Linking)
IP  - 754
DP  - 2011 Apr
TI  - [Home care day to day and ethical reflection].
PG  - 52
FAU - Dayde, Marie-Claude
AU  - Dayde MC
AD  - mc.dayde@wanadoo.fr
LA  - fre
PT  - Journal Article
TT  - Soins a domicile au quotidien et reflexion ethique.
PL  - France
TA  - Soins
JT  - Soins; la revue de reference infirmiere
JID - 20910580R
MH  - Home Care Services/*ethics
MH  - Humans
EDAT- 2011/05/18 06:00
MHDA- 2011/06/29 06:00
CRDT- 2011/05/18 06:00
PHST- 2011/05/18 06:00 [entrez]
PHST- 2011/05/18 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
PST - ppublish
SO  - Soins. 2011 Apr;(754):52.


PMID- 21574317
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20110516
IS  - 0038-0814 (Print)
IS  - 0038-0814 (Linking)
IP  - 754
DP  - 2011 Apr
TI  - [The ethics of the healthcare manager].
PG  - 50-1
AB  - I After having become disassociated from the religious influence, management
      ethics has become caught up in the concept of management. Nowadays, healthcare
      managers, as such, must remain the kingpin, working midway between managing human
      relations and administering healthcare. They draw on their personal values to
      structure their professional position. As part of a nursing collective, managers'
      ethics are anchored in the care-giving practice.
FAU - Durand, Jean-Pierre
AU  - Durand JP
AD  - Cadre Superieur de Sante, Centre Hospitalier Specialise, Angers.
      jpantoinedurand@gmail.com
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - L'ethique du cadre de sante.
PL  - France
TA  - Soins
JT  - Soins; la revue de reference infirmiere
JID - 20910580R
MH  - Delivery of Health Care/*ethics/*organization & administration
EDAT- 2011/05/18 06:00
MHDA- 2011/06/29 06:00
CRDT- 2011/05/18 06:00
PHST- 2011/05/18 06:00 [entrez]
PHST- 2011/05/18 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
PST - ppublish
SO  - Soins. 2011 Apr;(754):50-1.


PMID- 21574316
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20110516
IS  - 0038-0814 (Print)
IS  - 0038-0814 (Linking)
IP  - 754
DP  - 2011 Apr
TI  - [Ageing, ethics and care].
PG  - 47-9
AB  - In today's society, ageing is a phenomenon which is as natural as it is complex. 
      Paradoxically, it is a sign of life. Elderly people must be treated with dignity 
      and spared from the prejudices which currently surround old age.
FAU - Fiat, Eric
AU  - Fiat E
AD  - Universite de Marne-la-Vallee. eric.fiat@wanadoo.fr
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Vieillissement, ethique et soins.
PL  - France
TA  - Soins
JT  - Soins; la revue de reference infirmiere
JID - 20910580R
MH  - Aged
MH  - *Aging
MH  - *Ethics
MH  - Geriatrics/*ethics
MH  - Humans
MH  - Personhood
EDAT- 2011/05/18 06:00
MHDA- 2011/06/29 06:00
CRDT- 2011/05/18 06:00
PHST- 2011/05/18 06:00 [entrez]
PHST- 2011/05/18 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
PST - ppublish
SO  - Soins. 2011 Apr;(754):47-9.


PMID- 21574314
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20151119
IS  - 0038-0814 (Print)
IS  - 0038-0814 (Linking)
IP  - 754
DP  - 2011 Apr
TI  - [Deciding to limit or stop acute care in paediatric intensive care].
PG  - 42-4
AB  - Staff in paediatric intensive care departments are faced with ethical questioning
      concerning their healthcare practice. Collaborative meetings involving all
      relevant professionals are essential in order to ensure the most appropriate,
      often difficult, decision is made, when it involves limiting or stopping ongoing 
      treatment. Two clinical situations illustrate this issue.
FAU - Ferreira, Paulo
AU  - Ferreira P
AD  - Cadre de Sante, Hopital Necker Enfants Malades, Paris (AP-HP).
      paulo.ferreira@nck.aphp.fr
FAU - Faury, Florence
AU  - Faury F
LA  - fre
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - Les decisions de limitation et d'arret des therapeutiques actives en reanimation 
      pediatrique.
PL  - France
TA  - Soins
JT  - Soins; la revue de reference infirmiere
JID - 20910580R
MH  - Critical Care/*ethics
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - Withholding Treatment/*ethics
EDAT- 2011/05/18 06:00
MHDA- 2011/06/29 06:00
CRDT- 2011/05/18 06:00
PHST- 2011/05/18 06:00 [entrez]
PHST- 2011/05/18 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
PST - ppublish
SO  - Soins. 2011 Apr;(754):42-4.


PMID- 21574311
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20110516
IS  - 0038-0814 (Print)
IS  - 0038-0814 (Linking)
IP  - 754
DP  - 2011 Apr
TI  - [Developing values].
PG  - 35-7
AB  - Changes in the meaning of values and the influence of the care ethic have altered
      the ways in which the moral values of care professionals are understood. The
      values expected of a professional are the same as for citizens, with the
      additional demand of competency.
FAU - Thominet, Patrick
AU  - Thominet P
AD  - IFSI, Centre Hospitalier Universitaire Paul Brousse, AP-HP, Villejuif.
      patrick.thominet@dfc.aphp.fr
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Les valeurs en devenir.
PL  - France
TA  - Soins
JT  - Soins; la revue de reference infirmiere
JID - 20910580R
MH  - Delivery of Health Care/*ethics
MH  - Humans
MH  - Social Values
EDAT- 2011/05/18 06:00
MHDA- 2011/06/29 06:00
CRDT- 2011/05/18 06:00
PHST- 2011/05/18 06:00 [entrez]
PHST- 2011/05/18 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
PST - ppublish
SO  - Soins. 2011 Apr;(754):35-7.


PMID- 21574310
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20110516
IS  - 0038-0814 (Print)
IS  - 0038-0814 (Linking)
IP  - 754
DP  - 2011 Apr
TI  - [Ethical principles in the care relationship].
PG  - 32-4
AB  - Ethical principles in the care relationship are at the heart of inter and
      multi-disciplinary communication quality between all the stakeholders. They give 
      meaning to actions and enable them to be applied in a fairer manner better suited
      to the person being treated.
FAU - Tocheport, Pascale
AU  - Tocheport P
AD  - Hopital Charles-Foix (AP-HP), Paris. Pascale.tocheport@wanadoo.fr
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Principes ethiques dans la relation de soins.
PL  - France
TA  - Soins
JT  - Soins; la revue de reference infirmiere
JID - 20910580R
MH  - Humans
MH  - Professional-Patient Relations/*ethics
EDAT- 2011/05/18 06:00
MHDA- 2011/06/29 06:00
CRDT- 2011/05/18 06:00
PHST- 2011/05/18 06:00 [entrez]
PHST- 2011/05/18 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
PST - ppublish
SO  - Soins. 2011 Apr;(754):32-4.


PMID- 21574309
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20110516
IS  - 0038-0814 (Print)
IS  - 0038-0814 (Linking)
IP  - 754
DP  - 2011 Apr
TI  - [Ethics, the absolute need of health personnel].
PG  - 31
FAU - Michon, Florence
AU  - Michon F
LA  - fre
PT  - Journal Article
TT  - L'ethique, une necessite absolue pour les soignants.
PL  - France
TA  - Soins
JT  - Soins; la revue de reference infirmiere
JID - 20910580R
MH  - Health Personnel/*ethics
MH  - Humans
EDAT- 2011/05/18 06:00
MHDA- 2011/06/29 06:00
CRDT- 2011/05/18 06:00
PHST- 2011/05/18 06:00 [entrez]
PHST- 2011/05/18 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
PST - ppublish
SO  - Soins. 2011 Apr;(754):31.


PMID- 21574306
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20110516
IS  - 0038-0814 (Print)
IS  - 0038-0814 (Linking)
IP  - 754
DP  - 2011 Apr
TI  - [Standard, performance and care of the disabled person].
PG  - 18-9
AB  - When caring for disabled people, the caregiver must learn to know them as a
      person. One of the main duties of teachers is to help students to change their
      outlook, so that rather than considering the performance, they consider the
      qualities inherent to the human being. Care must be based on this ethical
      understanding of humans whose only dignity lies in their humanity.
FAU - Haberey-Knuessi, Veronique
AU  - Haberey-Knuessi V
AD  - Haute Ecole de Sante Arc, Neuchatel, Suisse. Veronique.Haberey-Knuessi@he-arc.ch
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Norme, performance et accompagnement du handicap.
PL  - France
TA  - Soins
JT  - Soins; la revue de reference infirmiere
JID - 20910580R
MH  - Community Health Services/*standards
MH  - *Disabled Persons
MH  - Humans
EDAT- 2011/05/18 06:00
MHDA- 2011/06/29 06:00
CRDT- 2011/05/18 06:00
PHST- 2011/05/18 06:00 [entrez]
PHST- 2011/05/18 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
PST - ppublish
SO  - Soins. 2011 Apr;(754):18-9.


PMID- 21574186
OWN - NLM
STAT- MEDLINE
DCOM- 20120229
LR  - 20211020
IS  - 1531-8257 (Electronic)
IS  - 0885-3185 (Linking)
VI  - 26
IP  - 8
DP  - 2011 Jul
TI  - Risk of surgical delivery to deep nuclei: a meta-analysis.
PG  - 1415-21
LID - 10.1002/mds.23770 [doi]
AB  - Many novel strategies aimed at neuroprotection or neurorestoration involve
      surgical delivery of agents to deep nuclei along multiple trajectories. Using
      intracerebral hemorrhage on a per-trajectory basis as our primary end point, we
      quantified the level of surgical risk associated with agent delivery to deep
      nuclei. Secondarily, we quantified other event rates and examined relationships
      between intracerebral hemorrhage and 8 variables related to patient and practice 
      characteristics. Meta-analytic techniques were used to pool complication rates
      reported in published articles involving deep brain stimulator electrode
      implantation or infusion of vectors, tissues, or trophic factors. One hundred
      nine studies were included in our analysis, comprising 6237 patients and 9890
      trajectories to deep nuclei. The estimated per-trajectory intracerebral
      hemorrhage rate was 1.57% (95% confidence interval, 1.26%-1.95%). The proportion 
      of trajectories leading to permanent or serious neurological deficits was 0.41%
      (0.28%-0.60%). The estimated mortality rate per trajectory was 0.14%
      (0.07%-0.29%). No relationship between intracerebral hemorrhage and sex, age,
      duration of disease, or exclusion of patients with surgical complications was
      observed; a significant positive relationship was observed with the use of
      microelectrode recording and a significant negative relationship with putamenal
      delivery. Our results show a significant difference in intracerebral hemorrhage
      rates between inoculations and electrode implantation. Our findings suggest that 
      studies involving multiple trajectories to deep nuclei involve a high level of
      risk. However, inoculations may be significantly safer than electrode
      implantation. Our analysis has implications for the ethics of preclinical
      research, independent review of risk, subject selection, and adverse event
      reporting.
CI  - Copyright (c) 2011 Movement Disorder Society.
FAU - Kimmelman, Jonathan
AU  - Kimmelman J
AD  - Biomedical Ethics Unit, Department of Social Studies of Medicine, McGill
      University, Montreal, Quebec, Canada. jonathan.kimmelman@mcgill.ca
FAU - Duckworth, Katherine
AU  - Duckworth K
FAU - Ramsay, Tim
AU  - Ramsay T
FAU - Voss, Tiffini
AU  - Voss T
FAU - Ravina, Bernard
AU  - Ravina B
FAU - Emborg, Marina Elena
AU  - Emborg ME
LA  - eng
GR  - P51 RR000167/RR/NCRR NIH HHS/United States
GR  - P51 RR000167-50/RR/NCRR NIH HHS/United States
GR  - C06 RR015459-01/RR/NCRR NIH HHS/United States
GR  - C06 RR020141-01/RR/NCRR NIH HHS/United States
GR  - P51 OD011106/OD/NIH HHS/United States
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20110514
PL  - United States
TA  - Mov Disord
JT  - Movement disorders : official journal of the Movement Disorder Society
JID - 8610688
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cerebral Hemorrhage/*etiology
MH  - Child
MH  - Databases, Factual/statistics & numerical data
MH  - Deep Brain Stimulation/*adverse effects
MH  - Electrodes, Implanted/adverse effects
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nervous System Diseases/*etiology
MH  - Risk Factors
MH  - Stroke/*etiology
MH  - Young Adult
PMC - PMC4532377
MID - NIHMS286950
EDAT- 2011/05/17 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/05/17 06:00
PHST- 2010/12/21 00:00 [received]
PHST- 2011/03/21 00:00 [revised]
PHST- 2011/04/04 00:00 [accepted]
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - 10.1002/mds.23770 [doi]
PST - ppublish
SO  - Mov Disord. 2011 Jul;26(8):1415-21. doi: 10.1002/mds.23770. Epub 2011 May 14.


PMID- 21574074
OWN - NLM
STAT- MEDLINE
DCOM- 20110909
LR  - 20211020
IS  - 1545-5815 (Electronic)
IS  - 0898-9621 (Linking)
VI  - 18
IP  - 3
DP  - 2011 May
TI  - Science and society: some "made-in-Canada" options for improving integration.
PG  - 194-216
LID - 10.1080/08989621.2011.575246 [doi]
AB  - In this article, the authors describe relatively recent efforts by scientific
      research agencies to promote, through various funding programs, the integration
      of social sciences and humanities with the natural sciences. This "integrated"
      approach seeks to study science through a broader interdisciplinary lens in order
      to better anticipate, understand, and address its ethical, legal, and social
      implications. The authors review the origins and evolution of this trend, as well
      the arguments which have been formulated by both proponents and critics of
      integration. By using Genome Canada's "GE(3)LS" Research Program as a case study,
      the authors discuss the successes and continuing challenges of this model based
      on evaluation results available to date. The authors then go on to examine and
      compare three possible models for improving the future success of the GE(3)LS
      research program, including: 1) enhancing the current integrated research
      approach through incremental refinements based on concrete evidence and lessons
      learned; 2) promoting greater interaction and synergy across GE(3)LS research
      projects through a deliberate, systematic and coordinated "hub and spoke"
      approach; and 3) taking a broad programmatic approach to GE(3)LS research by
      creating a central resource of available expertise and advisory capacity.
FAU - Kosseim, Patricia
AU  - Kosseim P
AD  - Genome Canada, Canada. patricia.kossheim@priv.gc.ca
FAU - Chapman, Sheila
AU  - Chapman S
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Account Res
JT  - Accountability in research
JID - 9100813
SB  - IM
MH  - Canada
MH  - Communication
MH  - *Delivery of Health Care, Integrated
MH  - Female
MH  - Genetic Research
MH  - Human Genome Project/*organization & administration
MH  - Humans
MH  - Interprofessional Relations
MH  - Male
MH  - Models, Theoretical
MH  - Quality Improvement
MH  - Research Design
MH  - *Science
MH  - *Societies
PMC - PMC3173746
EDAT- 2011/05/17 06:00
MHDA- 2011/09/10 06:00
CRDT- 2011/05/17 06:00
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2011/09/10 06:00 [medline]
AID - 937541072 [pii]
AID - 10.1080/08989621.2011.575246 [doi]
PST - ppublish
SO  - Account Res. 2011 May;18(3):194-216. doi: 10.1080/08989621.2011.575246.


PMID- 21574073
OWN - NLM
STAT- MEDLINE
DCOM- 20110909
LR  - 20161125
IS  - 1545-5815 (Electronic)
IS  - 0898-9621 (Linking)
VI  - 18
IP  - 3
DP  - 2011 May
TI  - Current ethical issues in synthetic biology: where should we go from here?
PG  - 181-93
LID - 10.1080/08989621.2011.575035 [doi]
AB  - Synthetic biology (SynBio) is an emerging scientific field which has quickly
      established momentum and visibility. Although no single definition of SynBio
      prevails, the field broadly encompasses the application of engineering principles
      to biology, redesigning biological materials and using them as new substrates to 
      create products and entities not otherwise found in nature. This article first
      reviews SynBio, highlighting the novel aspects of this technology. It then
      synthesizes ethical issues highlighted in the literature to date and makes some
      initial claims that research on the ethical aspects of SynBio should: avoid
      creating a new subtype of bioethics, concentrate on novel concepts and problems, 
      and be situated within a context of cooperative interdisciplinary investigation.
FAU - Newson, Ainsley J
AU  - Newson AJ
AD  - Centre for Ethics in Medicine, School of Social and Community Medicine,
      University of Bristol, UK. ainsley.newson@bristol.ac.uk
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Account Res
JT  - Accountability in research
JID - 9100813
SB  - IM
MH  - *Bioethics
MH  - Biotechnology/*ethics/legislation & jurisprudence
MH  - Female
MH  - Forecasting
MH  - Genes, Synthetic
MH  - Genetic Engineering/*ethics/legislation & jurisprudence
MH  - Humans
MH  - Male
MH  - Needs Assessment
MH  - Risk Assessment
MH  - Synthetic Biology/*ethics/methods
MH  - United Kingdom
EDAT- 2011/05/17 06:00
MHDA- 2011/09/10 06:00
CRDT- 2011/05/17 06:00
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2011/09/10 06:00 [medline]
AID - 937541138 [pii]
AID - 10.1080/08989621.2011.575035 [doi]
PST - ppublish
SO  - Account Res. 2011 May;18(3):181-93. doi: 10.1080/08989621.2011.575035.


PMID- 21574072
OWN - NLM
STAT- MEDLINE
DCOM- 20110909
LR  - 20110516
IS  - 1545-5815 (Electronic)
IS  - 0898-9621 (Linking)
VI  - 18
IP  - 3
DP  - 2011 May
TI  - The microphysics of accountability.
PG  - 163-80
LID - 10.1080/08989621.2011.575034 [doi]
AB  - How is it possible to deploy the law to create and perform accountability? To
      answer this question, I address the argumentative function of the law in order to
      legitimize genetic medicine. Using interview data, I will in particular elaborate
      on how medical experts strive to convince interviewing social scientists that
      their own professional action is above all ethical reproach. For this purpose,
      medical experts capitalize on the law in specific ways. It is the aim of this
      article to expound exactly how this happens during qualitative research
      interviews. The analysis of the interview data is informed by the works of Sheila
      Jasanoff and Michel Foucault. The former provides an instructive conceptual
      background for demonstrating how the law serves as an important element of
      accountability practices. The latter is known for his plea not to understand the 
      law in repressive terms. Accordingly, the law does not prohibit specific medical 
      practices, but in a specific sense it rather makes medical practice socially
      robust. Based on qualitative analysis of interview data, I conclude that
      referring to the law allows experts of genetic medicine to evade engaging with
      ethical and social aspects of their work. The law was rhetorically utilized to
      bring a discussion on such issues to a communicative closure. For that purpose,
      the existence of the law was presented as proof that undesirable practices would 
      not be possible and consequently further discussions of the matter would be
      unnecessary. The law allows medical experts to transfer ethical problems to other
      places and actors and also to promote their professional interests.
FAU - Wieser, Bernhard
AU  - Wieser B
AD  - Inter-University Research Centre for Technology, Work, and Culture, Graz,
      Austria. wieser@ifz.tugraz.at
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Account Res
JT  - Accountability in research
JID - 9100813
SB  - IM
MH  - Austria
MH  - Decision Making
MH  - Female
MH  - Genetic Counseling/ethics/legislation & jurisprudence
MH  - Genetic Predisposition to Disease
MH  - Genetic Privacy
MH  - Genetic Research/ethics/legislation & jurisprudence
MH  - Genetic Testing/*ethics/*legislation & jurisprudence
MH  - Genomics/ethics/standards
MH  - Humans
MH  - Male
MH  - Quality Control
MH  - *Social Responsibility
EDAT- 2011/05/17 06:00
MHDA- 2011/09/10 06:00
CRDT- 2011/05/17 06:00
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2011/09/10 06:00 [medline]
AID - 937540845 [pii]
AID - 10.1080/08989621.2011.575034 [doi]
PST - ppublish
SO  - Account Res. 2011 May;18(3):163-80. doi: 10.1080/08989621.2011.575034.


PMID- 21574071
OWN - NLM
STAT- MEDLINE
DCOM- 20110909
LR  - 20110516
IS  - 1545-5815 (Electronic)
IS  - 0898-9621 (Linking)
VI  - 18
IP  - 3
DP  - 2011 May
TI  - A clinical perspective on ethical issues in genetic testing.
PG  - 148-62
LID - 10.1080/08989621.2011.575033 [doi]
AB  - Genetic testing is traditionally preceded by counselling to discuss its
      advantages and disadvantages with individuals so they can make informed
      decisions. The new technique of whole genome or exome sequencing, which is
      currently only used in research settings, can identify many gene mutations,
      including substantial numbers of mutations with unknown pathological effect; it
      may, therefore, threaten this balanced approach if it is used in a clinical
      setting. We discuss the ethical challenges of several approaches to pre- and
      postnatal DNA testing, individual privacy versus the interests of families and of
      scientists, and the clinician's duty to re-contact if new information or options 
      become available.
FAU - Sijmons, R H
AU  - Sijmons RH
AD  - Department of Genetics, University Medical Centre Groningen, University of
      Groningen, The Netherlands. r.h.sijmons@medgen.umcg.nl
FAU - Van Langen, I M
AU  - Van Langen IM
FAU - Sijmons, J G
AU  - Sijmons JG
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Account Res
JT  - Accountability in research
JID - 9100813
SB  - IM
MH  - Female
MH  - Genetic Counseling/*ethics/methods
MH  - Genetic Diseases, Inborn/*diagnosis/prevention & control
MH  - *Genetic Predisposition to Disease
MH  - Genetic Privacy/ethics/legislation & jurisprudence
MH  - Genetic Testing/*ethics/methods
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - Neonatal Screening/*ethics/methods
MH  - Netherlands
MH  - Pregnancy
MH  - Prenatal Diagnosis/ethics/methods
MH  - Quality Control
EDAT- 2011/05/17 06:00
MHDA- 2011/09/10 06:00
CRDT- 2011/05/17 06:00
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2011/09/10 06:00 [medline]
AID - 937541013 [pii]
AID - 10.1080/08989621.2011.575033 [doi]
PST - ppublish
SO  - Account Res. 2011 May;18(3):148-62. doi: 10.1080/08989621.2011.575033.


PMID- 21574069
OWN - NLM
STAT- MEDLINE
DCOM- 20110909
LR  - 20110516
IS  - 1545-5815 (Electronic)
IS  - 0898-9621 (Linking)
VI  - 18
IP  - 3
DP  - 2011 May
TI  - Editorial: genetic and genomic research-changing patterns of accountability.
PG  - 121-31
LID - 10.1080/08989621.2011.575031 [doi]
AB  - Debates about genomic science have raised questions about the implications for
      ethics and accountability. Accountability has external and internal aspects.
      Whereas ethical review, including attention to appropriate consent procedures,
      has been central to 'giving an account' externally, there are also issues
      internal to the practice of science itself. The pursuit of truth is central to
      the scientific endeavour, but truths can sometimes be 'inconvenient', leading to 
      complex questions of accountability that go beyond the issues of consent. This is
      illustrated by the case of the Havasupai.
FAU - Lunshof, Jeantine E
AU  - Lunshof JE
FAU - Chadwick, Ruth
AU  - Chadwick R
LA  - eng
PT  - Editorial
PL  - United States
TA  - Account Res
JT  - Accountability in research
JID - 9100813
SB  - IM
MH  - Biomedical Research/*ethics/standards
MH  - Female
MH  - Genetics, Medical/*ethics/standards
MH  - Genome
MH  - Human Genome Project/*ethics
MH  - Humans
MH  - Male
MH  - Quality Control
MH  - *Social Responsibility
EDAT- 2011/05/17 06:00
MHDA- 2011/09/10 06:00
CRDT- 2011/05/17 06:00
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2011/09/10 06:00 [medline]
AID - 937540880 [pii]
AID - 10.1080/08989621.2011.575031 [doi]
PST - ppublish
SO  - Account Res. 2011 May;18(3):121-31. doi: 10.1080/08989621.2011.575031.


PMID- 21574032
OWN - NLM
STAT- MEDLINE
DCOM- 20110916
LR  - 20211020
IS  - 1867-0687 (Electronic)
VI  - 7
IP  - 2
DP  - 2011 May
TI  - Swaddling: a traditional care method rediscovered.
PG  - 155-60
LID - 10.1007/s12519-011-0268-6 [doi]
AB  - BACKGROUND: This study was undertaken to compare the sleep profiles of healthy
      infants in swaddling and sleeping bag conditions. METHODS: Polysomnographs of 85 
      healthy infants (40 in the study group, 45 in the control group) with a mean age 
      of 7.5 weeks were recorded in the sleeping laboratory. A positive decision from
      the local Ethics Committee and the written consent of the parents were obtained
      for the study. RESULTS: Swaddling significantly reduces the rate of spontaneous
      waking (events/h: 1.39 [0.85-2.77] vs. 2.81 [1.49-4.53], P=0.020) and the number 
      of sleep stage changes (events/h: 3.82 [2.97-5.16] vs. 5.37 [3.58-6.67],
      P=0.015). Swaddling promotes quiet sleep (36.37% [29%-40.31%] vs. 30.2%
      [24.45%-36.78%], P=0.032), the time spent awake was decreased (8.98%
      [4.62%-14.25%] vs. 14.17% [9.2%-18.94%], P=0.001) and sleep efficiency was
      increased (91.02% [85.75%-95.38%] vs. 85.83% [81.06%-90.8%], P=0.001).
      CONCLUSION: Swaddling promotes a more quiet sleep in infants.
FAU - Meyer, Lars Eckehard
AU  - Meyer LE
AD  - Carl-Thiem-Klinikum Cottbus gGmbH, Clinic for Paediatric and Adolescent Medicine,
      Academic Teaching Hospital of the Charite - Universitatsmedizin Berlin, Cottbus, 
      Germany. l.meyer@ctk.de
FAU - Erler, Thomas
AU  - Erler T
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20110515
PL  - Switzerland
TA  - World J Pediatr
JT  - World journal of pediatrics : WJP
JID - 101278599
SB  - IM
MH  - Arousal/physiology
MH  - *Bedding and Linens
MH  - *Clothing
MH  - Humans
MH  - Infant
MH  - *Infant Care/methods
MH  - Polysomnography
MH  - *Sleep/physiology
MH  - Sleep Stages
MH  - Sudden Infant Death/prevention & control
MH  - Supine Position
EDAT- 2011/05/17 06:00
MHDA- 2011/09/17 06:00
CRDT- 2011/05/17 06:00
PHST- 2010/08/07 00:00 [received]
PHST- 2010/12/07 00:00 [accepted]
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2011/09/17 06:00 [medline]
AID - 10.1007/s12519-011-0268-6 [doi]
PST - ppublish
SO  - World J Pediatr. 2011 May;7(2):155-60. doi: 10.1007/s12519-011-0268-6. Epub 2011 
      May 15.


PMID- 21573873
OWN - NLM
STAT- MEDLINE
DCOM- 20121001
LR  - 20120424
IS  - 1438-2199 (Electronic)
IS  - 0939-4451 (Linking)
VI  - 42
IP  - 5
DP  - 2012 May
TI  - Neurogenic differentiation of amniotic fluid stem cells.
PG  - 1591-6
LID - 10.1007/s00726-011-0929-8 [doi]
AB  - In 2003, human amniotic fluid has been shown to contain stem cells expressing
      Oct-4, a marker for pluripotency. This finding initiated a rapidly growing and
      very promising new stem cell research field. Since then, amniotic fluid stem
      (AFS) cells have been demonstrated to harbour the potential to differentiate into
      any of the three germ layers and to form three-dimensional aggregates, so-called 
      embryoid bodies, known as the principal step in the differentiation of
      pluripotent stem cells. Marker selection and minimal dilution approaches allow
      the establishment of monoclonal AFS cell lineages with high proliferation
      potential. AFS cells have a lower risk for tumour development and do not raise
      the ethical issues of embryonic stem cells. Compared to induced pluripotent stem 
      cells, AFS cells do not need exogenic treatment to induce pluripotency, are
      chromosomal stable and do not harbour the epigenetic memory and accumulated
      somatic mutations of specific differentiated source cells. Compared to adult stem
      cells, AFS can be grown in larger quantities and show higher differentiation
      potential. Accordingly, in the recent past, AFS became increasingly accepted as
      an optimal tool for basic research and probably also for specific cell-based
      therapies. Here, we review the current knowledge on the neurogenic
      differentiation potential of AFS cells.
FAU - Rosner, M
AU  - Rosner M
AD  - Institute of Medical Genetics, Medical University of Vienna, Wahringer Strasse
      10, 1090, Vienna, Austria.
FAU - Mikula, M
AU  - Mikula M
FAU - Preitschopf, A
AU  - Preitschopf A
FAU - Feichtinger, M
AU  - Feichtinger M
FAU - Schipany, K
AU  - Schipany K
FAU - Hengstschlager, M
AU  - Hengstschlager M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110515
PL  - Austria
TA  - Amino Acids
JT  - Amino acids
JID - 9200312
RN  - 0 (Octamer Transcription Factor-3)
SB  - IM
MH  - Amniotic Fluid/*cytology
MH  - *Cell Differentiation
MH  - Cell Lineage
MH  - Embryonic Stem Cells/*cytology
MH  - Female
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*cytology
MH  - Neurons/*cytology
MH  - Octamer Transcription Factor-3/metabolism
MH  - Pregnancy
EDAT- 2011/05/17 06:00
MHDA- 2012/10/02 06:00
CRDT- 2011/05/17 06:00
PHST- 2011/04/13 00:00 [received]
PHST- 2011/04/28 00:00 [accepted]
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2012/10/02 06:00 [medline]
AID - 10.1007/s00726-011-0929-8 [doi]
PST - ppublish
SO  - Amino Acids. 2012 May;42(5):1591-6. doi: 10.1007/s00726-011-0929-8. Epub 2011 May
      15.


PMID- 21573081
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20220330
IS  - 1178-2021 (Electronic)
IS  - 1176-6328 (Linking)
VI  - 7
DP  - 2011
TI  - When neurologist and patient disagree on reasonable risk: new challenges in
      prescribing for patients with multiple sclerosis.
PG  - 197-208
LID - 10.2147/NDT.S17522 [doi]
AB  - New more powerful therapies for the treatment of multiple sclerosis may also
      confer a potential for unprecedented life-endangering side effects. How does a
      physician respond to a patient's request for a treatment the benefit of which
      cannot be clearly established as worth its risk? The current challenge with
      prescription of natalizumab (Tysabri((R)), Biogen Idec) is used to illustrate how
      this conflict creates an opportunity to re-examine our goals as physicians and
      the nature of the physician-patient relationship. Understanding the physician's
      role in that partnership, and the ethical and psychological issues impacting on
      how reasonable risk is determined, can improve the neurologist's capacity to
      explicate such quandaries. Redefining what is required to mediate disagreement
      between doctors and patients about reasonable risk is at the heart of why many of
      us became physicians. However, such nuanced interpersonal dynamics of patient
      care can be neglected due to the time and resource pressures of our practices.
      These demands have increased the seductiveness of the efficiencies promoted by
      the trend toward the pseudo-objectification of evidence-based care, which has
      arguably monopolized the healing conversation often to the detriment of the
      shared narrative. We examine and attempt to reframe the fiduciary and
      biopsychosocial contretemps of the doctor and patient disagreeing on risk,
      emphasizing its humanistic, relational dimensions.
FAU - Kachuck, Norman J
AU  - Kachuck NJ
AD  - University of Southern California, Keck School of Medicine, Los Angeles, CA, USA.
LA  - eng
PT  - Journal Article
DEP - 20110419
PL  - New Zealand
TA  - Neuropsychiatr Dis Treat
JT  - Neuropsychiatric disease and treatment
JID - 101240304
PMC - PMC3090283
OTO - NOTNLM
OT  - medical decision-making
OT  - medical ethics
OT  - multiple sclerosis
OT  - natalizumab
OT  - patient-physician relationship
EDAT- 2011/05/17 06:00
MHDA- 2011/05/17 06:01
CRDT- 2011/05/17 06:00
PHST- 2011/04/18 00:00 [received]
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2011/05/17 06:01 [medline]
AID - 10.2147/NDT.S17522 [doi]
AID - ndt-7-197 [pii]
PST - ppublish
SO  - Neuropsychiatr Dis Treat. 2011;7:197-208. doi: 10.2147/NDT.S17522. Epub 2011 Apr 
      19.


PMID- 21572889
OWN - NLM
STAT- MEDLINE
DCOM- 20110830
LR  - 20211020
IS  - 1552-4833 (Electronic)
IS  - 1552-4825 (Linking)
VI  - 155A
IP  - 4
DP  - 2011 Apr
TI  - Study newsletters, community and ethics advisory boards, and focus group
      discussions provide ongoing feedback for a large biobank.
PG  - 737-41
LID - 10.1002/ajmg.a.33896 [doi]
AB  - The Personalized Medicine Research Project (PMRP) is a population-based biobank
      with more than 20,000 adult participants in central Wisconsin. A Community
      Advisory Group (CAG) and Ethics and Security Advisory Board (ESAB) provide
      ongoing feedback. In addition, the study newsletter is used as a two-way
      communication tool with study participants. The aim of this study was to assess
      and compare feedback received from these communication/consultation strategies
      with results from focus group discussions in relation to protocol changes. In
      summer 2009, enrollee focus groups were held addressing these topics: newsletter 
      format, readability, and content of three articles written to solicit PMRP
      subject feedback. The CAG and ESAB jointly reviewed focus group results,
      discussed protocol changes to access residual blood samples, and made
      recommendations about the general communication approach. Nearly everyone in
      three focus groups stated that they wanted more information about PMRP. No focus 
      group participant said that accessing stored samples would have changed their
      enrollment decision. Most said they wanted to be informed directly about changes 
      affecting their original consent. For minimal-risk PMRP protocol changes, the
      community, CAG, and ESAB were comfortable with an opt-out model because of the
      initial broad consent. The planned duration of the biobank extends for decades;
      therefore regular, ongoing communication to enrollees is necessary to maintain
      awareness and trust, especially relating to protocol changes reflecting evolving 
      science. The multi-faceted approach to communication including newsletters,
      external advisory boards, and focus group discussions has been successful for the
      PMRP biobank and may be a model for others to consider.
CI  - Copyright (c) 2011 Wiley-Liss, Inc.
FAU - McCarty, Catherine A
AU  - McCarty CA
AD  - Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield,
      Wisconsin, USA. mccarty.catherine@mcrf.mfldclin.edu
FAU - Garber, Ann
AU  - Garber A
FAU - Reeser, Jonathan C
AU  - Reeser JC
FAU - Fost, Norman C
AU  - Fost NC
CN  - Personalized Medicine Research Project Community Advisory Group and Ethics and
      Security Advisory Board
LA  - eng
GR  - U01 HG004608/HG/NHGRI NIH HHS/United States
GR  - U01 HG004608-01/HG/NHGRI NIH HHS/United States
GR  - 1U01HG004608-01/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110315
PL  - United States
TA  - Am J Med Genet A
JT  - American journal of medical genetics. Part A
JID - 101235741
SB  - IM
MH  - Adult
MH  - Behavioral Research
MH  - Databases, Genetic/ethics/standards/*statistics & numerical data
MH  - *Focus Groups
MH  - Humans
MH  - Periodicals as Topic
MH  - *Precision Medicine
PMC - PMC3092645
MID - NIHMS261916
OTO - NOTNLM
OT  - Biobank
OT  - Community engagement
OT  - Ethics
OT  - Focus groups
OT  - Newsletters
IR  - Bartkowiak M
FIR - Bartkowiak, Mat
IR  - Boehning P
FIR - Boehning, Phil
IR  - Bredl S
FIR - Bredl, Sharon
IR  - Brubaker M
FIR - Brubaker, Margaret
IR  - Frey M
FIR - Frey, Mary
IR  - Gall P
FIR - Gall, Pat
IR  - Gardner J
FIR - Gardner, Jodie
IR  - Kaster N
FIR - Kaster, Nancy
IR  - Kelly C
FIR - Kelly, Colleen
IR  - Kobs M
FIR - Kobs, Mike
IR  - Kommer N
FIR - Kommer, Norm
IR  - Krake D
FIR - Krake, Darlene
IR  - Krueger RM
FIR - Krueger, Reverend Mark
IR  - Leveluis J
FIR - Leveluis, Julie
IR  - Minor J
FIR - Minor, Jerry
IR  - Moen N
FIR - Moen, Noreen
IR  - Paul M
FIR - Paul, Mike
IR  - Schneider M
FIR - Schneider, Marlin
IR  - Schultz S
FIR - Schultz, Scott
IR  - Schwanebeck J
FIR - Schwanebeck, Jean
IR  - Botkin J
FIR - Botkin, Jeffrey
IR  - Clayton EW
FIR - Clayton, Ellen Wright
IR  - Finucan FJ
FIR - Finucan, Father J Thomas
IR  - Fost NC
FIR - Fost, Norman C
IR  - Larson BA
FIR - Larson, Bishop April U
IR  - Merz JF
FIR - Merz, Jon F
IR  - McQuillan GM
FIR - McQuillan, Geraldine M
IR  - Rothenberg KH
FIR - Rothenberg, Karen H
IR  - Slack W
FIR - Slack, Warner
EDAT- 2011/05/17 06:00
MHDA- 2011/08/31 06:00
CRDT- 2011/05/17 06:00
PHST- 2010/08/06 00:00 [received]
PHST- 2010/12/22 00:00 [accepted]
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2011/08/31 06:00 [medline]
AID - 10.1002/ajmg.a.33896 [doi]
PST - ppublish
SO  - Am J Med Genet A. 2011 Apr;155A(4):737-41. doi: 10.1002/ajmg.a.33896. Epub 2011
      Mar 15.


PMID- 21572582
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 1050-8422 (Print)
IS  - 1050-8422 (Linking)
VI  - 21
IP  - 2
DP  - 2011 Jan 1
TI  - The Influence of Temporal Orientation and Affective Frame on use of Ethical
      Decision-Making Strategies.
PG  - 127-146
AB  - This study examined the role of temporal orientation and affective frame in the
      execution of ethical decision-making strategies. In reflecting on a past
      experience or imagining a future experience, participants thought about
      experiences that they considered either positive or negative. The participants
      recorded their thinking about that experience by responding to several questions,
      and their responses were content-analyzed for the use of ethical decision-making 
      strategies. The findings indicated that a future temporal orientation was
      associated with greater strategy use. Likewise, a positive affective frame was
      associated with greater strategy use. Future orientation may permit better
      strategy execution than a past orientation because it facilitates more objective,
      balanced contemplation of the reflected-upon situation, and minimizes potential
      self-threat associated with past behavior. A positive affective frame likely
      improves strategy execution because it facilitates active analysis of the
      experience. Future directions and implications of these findings are discussed.
FAU - Martin, Laura E
AU  - Martin LE
AD  - Midwestern State University.
FAU - Stenmark, Cheryl K
AU  - Stenmark CK
FAU - Thiel, Chase E
AU  - Thiel CE
FAU - Antes, Alison L
AU  - Antes AL
FAU - Mumford, Michael D
AU  - Mumford MD
FAU - Connelly, Shane
AU  - Connelly S
FAU - Devenport, Lynn D
AU  - Devenport LD
LA  - eng
GR  - R01 NR010341/NR/NINR NIH HHS/United States
GR  - R01 NR010341-02/NR/NINR NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Ethics Behav
JT  - Ethics & behavior
JID - 9102086
PMC - PMC3092480
MID - NIHMS291730
EDAT- 2011/05/17 06:00
MHDA- 2011/05/17 06:01
CRDT- 2011/05/17 06:00
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2011/05/17 06:01 [medline]
AID - 10.1080/10508422.2011.551470 [doi]
PST - ppublish
SO  - Ethics Behav. 2011 Jan 1;21(2):127-146. doi: 10.1080/10508422.2011.551470.


PMID- 21572507
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20220729
IS  - 2153-3539 (Electronic)
VI  - 2
DP  - 2011 Mar 31
TI  - Global manipulation of digital images can lead to variation in cytological
      diagnosis.
PG  - 20
LID - 10.4103/2153-3539.78498 [doi]
AB  - BACKGROUND: With the adoption of a completely electronic workflow by several
      journals and the advent of telepathology, digital imaging has become an integral 
      part of every scientific research. However, manipulating digital images is very
      easy, and it can lead to misinterpretations. AIM: To analyse the impact of
      manipulating digital images on their diagnosis. DESIGN: Digital images were
      obtained from Papanicolaou-stained smears of dysplastic and normal oral
      epithelium. They were manipulated using GNU Image Manipulation Program (GIMP) to 
      alter their brightness and contrast and color levels. A Power Point presentation 
      composed of slides of these manipulated images along with the unaltered originals
      arranged randomly was created. The presentation was shown to five observers
      individually who rated the images as normal, mild, moderate or severe dysplasia. 
      Weighted kappa statistics was used to measure and assess the levels of agreement 
      between observers. RESULTS: Levels of agreement between manipulated images and
      original images varied greatly among observers. Variation in diagnosis was in the
      form of overdiagnosis or under-diagnosis, usually by one grade. CONCLUSION:
      Global manipulations of digital images of cytological slides can significantly
      affect their interpretation. Such manipulations should therefore be kept to a
      minimum, and avoided wherever possible.
FAU - Prasad, H
AU  - Prasad H
AD  - Department of Oral Pathology and Microbiology, Modern Dental College and Research
      Centre, Indore, M.P - 453 112, India.
FAU - Wanjari, Sangeeta
AU  - Wanjari S
FAU - Parwani, Rajkumar
AU  - Parwani R
LA  - eng
PT  - Journal Article
DEP - 20110331
PL  - United States
TA  - J Pathol Inform
JT  - Journal of pathology informatics
JID - 101528849
PMC - PMC3073066
OTO - NOTNLM
OT  - Author guidelines
OT  - ethics
OT  - image manipulation
OT  - photomicrographs
OT  - telepathology
EDAT- 2011/05/17 06:00
MHDA- 2011/05/17 06:01
CRDT- 2011/05/17 06:00
PHST- 2011/02/02 00:00 [received]
PHST- 2011/02/14 00:00 [accepted]
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2011/05/17 06:01 [medline]
AID - 10.4103/2153-3539.78498 [doi]
AID - S2153-3539(22)00196-1 [pii]
PST - epublish
SO  - J Pathol Inform. 2011 Mar 31;2:20. doi: 10.4103/2153-3539.78498.


PMID- 21572469
OWN - NLM
STAT- MEDLINE
DCOM- 20110818
LR  - 20110516
IS  - 0035-6484 (Print)
IS  - 0035-6484 (Linking)
VI  - 46
IP  - 2
DP  - 2011 Mar-Apr
TI  - [Restraints and psychiatric emergencies in the metropolitan area of Rome].
PG  - 97-121
LID - 10.1708/626.7311 [doi]
AB  - This research, sponsored by the coordination center for the Psychiatric,
      Diagnosis, and Cure Services (SPDC), would verify if, and in which measure, the
      mechanical restraint is still today a mean necessary for the management of the
      states of agitation in the psychiatric emergencies. The perspective in which the 
      search is developed has been that to consider the restraint a point of synthesis 
      of the matters of ethic, of quality and safety, and not only and exclusively a
      moral matter. The results of the search have showed a conspicuous and diffused
      use the mechanical restraint as routine mean in the management of the serious
      agitation and the incisive influence of endogenous (SPDC) factors of risk and
      exogenous (catchment's area and mental health department) in to determine a
      recourse to it. In conclusion, he sustains that a effectiveness and winner action
      to limit and to eliminate, in perspective, the mechanical restraint in the
      current routine of SPDC cannot put aside at the most from an appointment level
      both type professional (leadership, staff training, guide lines, yearly audit)
      both type normative (the restraint as discriminating for the accreditation and
      for the evaluation of the executives, and business procedures for prevention of
      risk in the safety's optics for patients and operators).
FAU - Sangiorgio, Pietro
AU  - Sangiorgio P
AD  - UOC Dipartimento di Salute Mentale, Distretto ASL RMH1, Frascati, Roma.
      p_sangiorgio@yahoo.it
FAU - Mosticoni, Stefano
AU  - Mosticoni S
CN  - Gruppo di lavoro del coordinamento SPDC Regione Lazio
LA  - ita
PT  - English Abstract
PT  - Journal Article
TT  - Contenzioni ed emergenze psichiatriche a Roma.
PL  - Italy
TA  - Riv Psichiatr
JT  - Rivista di psichiatria
JID - 0425672
SB  - IM
MH  - Emergencies
MH  - Environment
MH  - Humans
MH  - Mental Disorders/*therapy
MH  - *Restraint, Physical/standards
MH  - Rome
MH  - Safety
MH  - Urban Health
EDAT- 2011/05/17 06:00
MHDA- 2011/08/19 06:00
CRDT- 2011/05/17 06:00
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2011/08/19 06:00 [medline]
AID - 10.1708/626.7311 [doi]
PST - ppublish
SO  - Riv Psichiatr. 2011 Mar-Apr;46(2):97-121. doi: 10.1708/626.7311.


PMID- 21572318
OWN - NLM
STAT- MEDLINE
DCOM- 20110823
LR  - 20220408
IS  - 1528-1175 (Electronic)
IS  - 0003-3022 (Linking)
VI  - 115
IP  - 1
DP  - 2011 Jul
TI  - Performance of the pediatric-sized i-gel compared with the Ambu AuraOnce
      laryngeal mask in anesthetized and ventilated children.
PG  - 102-10
LID - 10.1097/ALN.0b013e318219d619 [doi]
AB  - BACKGROUND: This prospective, randomized, controlled trial compares the
      performance of the pediatric i-gel (Intersurgical Ltd., Wokingham, United
      Kingdom) with the Ambu AuraOnce laryngeal mask (Ambu A/S, Ballerup, Denmark) in
      anesthetized and ventilated children. METHODS: With ethics committee approval and
      written informed consent, the authors included 208 children, aged 0-17 yr,
      scheduled for elective day-surgery under general anesthesia. The primary outcome 
      variable was oropharyngeal leak pressure. Other outcome variables were
      first-attempt and overall success, time to sufficient ventilation, and adverse
      events. RESULTS: Demographic data did not differ between groups. The leak
      pressure of the i-gel was significantly higher than the leak pressure of the Ambu
      (mean +/- SD: 22 +/- 5 cm H(2)O vs. 19 +/- 3, P < 0.01). First-attempt success
      was 91% for the i-gel and 93% for the Ambu (P = 0.50). Overall success was 93%
      for the i-gel versus 98% for the Ambu (P = 0.10). Successfully inserted i-gels
      needed to be secured by taping in place to ensure the seal in 44% (0% with the
      Ambu, P < 0.01). Insertion was faster with the Ambu (24 +/- 8 s vs. 27 +/- 11, P 
      = 0.02). There were no major side effects with either device. CONCLUSIONS: The
      leak pressure of the i-gel was statistically but not clinically significantly
      higher than the leak pressure of the Ambu. Time to insertion was longer with the 
      i-gel. Both airway devices are suitable for positive pressure ventilation with
      high success rates in infants and children. Because the i-gel is prone to sliding
      out, it must be taped in place to avoid loss of the airway.
FAU - Theiler, Lorenz G
AU  - Theiler LG
AD  - Department of Anesthesiology and Pain Therapy, Inselspital, University Hospital
      Bern, University of Bern, Bern, Switzerland.
FAU - Kleine-Brueggeney, Maren
AU  - Kleine-Brueggeney M
FAU - Luepold, Barbara
AU  - Luepold B
FAU - Stucki, Franziska
AU  - Stucki F
FAU - Seiler, Stefan
AU  - Seiler S
FAU - Urwyler, Natalie
AU  - Urwyler N
FAU - Greif, Robert
AU  - Greif R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Anesthesiology
JT  - Anesthesiology
JID - 1300217
SB  - IM
MH  - Adolescent
MH  - Airway Management/adverse effects/*instrumentation
MH  - *Anesthesia, General/adverse effects
MH  - Child
MH  - Child, Preschool
MH  - Disposable Equipment
MH  - Equipment Design
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - *Laryngeal Masks/adverse effects
MH  - Male
MH  - Postoperative Complications/epidemiology
MH  - *Respiration, Artificial/adverse effects
MH  - Treatment Outcome
EDAT- 2011/05/17 06:00
MHDA- 2011/08/24 06:00
CRDT- 2011/05/17 06:00
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2011/08/24 06:00 [medline]
AID - 10.1097/ALN.0b013e318219d619 [doi]
PST - ppublish
SO  - Anesthesiology. 2011 Jul;115(1):102-10. doi: 10.1097/ALN.0b013e318219d619.


PMID- 21571977
OWN - NLM
STAT- MEDLINE
DCOM- 20110823
LR  - 20151119
IS  - 1758-1052 (Electronic)
IS  - 0956-4624 (Linking)
VI  - 22
IP  - 5
DP  - 2011 May
TI  - Consent, confidentiality and curing sexually transmitted infection: an ethical
      trilemma.
PG  - 281-5
LID - 10.1258/ijsa.2009.009373 [doi]
AB  - When treating contacts of patients with sexually transmitted infections (STIs),
      health professionals may face conflicting ethical imperatives. We surveyed middle
      grade doctors in genitourinary (GU) medicine and asked how they would manage a
      hypothetical clinical scenario. This was analysed on the basis of principles of
      respect for autonomy and beneficence/non-maleficence to assess how they weigh up 
      duties of informed consent (autonomy of patient), partner confidentiality
      (autonomy of partner) and the need to achieve a good medical outcome. Responses
      indicated that the strategies that they employ in practice - what they actually
      say to patients (and what they leave unsaid) - balance the conflicting
      requirements of these ethical principles in quite different ways, some of which
      appear ethically problematic.
FAU - Dunphy, K P
AU  - Dunphy KP
AD  - West Hertfordshire Sexual Health Directorate, West Hertfordshire Hospitals NHS
      Trust, Watford Sexual Health Centre, Watford General Hospital, Watford, UK.
      kilian.dunphy@whht.nhs.uk
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Int J STD AIDS
JT  - International journal of STD & AIDS
JID - 9007917
SB  - IM
MH  - Confidentiality/*ethics
MH  - Contact Tracing/*ethics
MH  - Ethics, Medical
MH  - Female
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Male
MH  - Physicians
MH  - Sexually Transmitted Diseases/*diagnosis/*drug therapy/prevention & control
MH  - Surveys and Questionnaires
EDAT- 2011/05/17 06:00
MHDA- 2011/08/24 06:00
CRDT- 2011/05/17 06:00
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2011/08/24 06:00 [medline]
AID - 22/5/281 [pii]
AID - 10.1258/ijsa.2009.009373 [doi]
PST - ppublish
SO  - Int J STD AIDS. 2011 May;22(5):281-5. doi: 10.1258/ijsa.2009.009373.


PMID- 21571716
OWN - NLM
STAT- MEDLINE
DCOM- 20110929
LR  - 20220408
IS  - 1715-5258 (Electronic)
IS  - 0008-350X (Linking)
VI  - 57
IP  - 5
DP  - 2011 May
TI  - Primary care of adults with developmental disabilities: Canadian consensus
      guidelines.
PG  - 541-53, e154-68
AB  - OBJECTIVE: To update the 2006 Canadian guidelines for primary care of adults with
      developmental disabilities (DD) and to make practical recommendations based on
      current knowledge to address the particular health issues of adults with DD.
      QUALITY OF EVIDENCE: Knowledgeable health care providers participating in a
      colloquium and a subsequent working group discussed and agreed on revisions to
      the 2006 guidelines based on a comprehensive review of publications, feedback
      gained from users of the guidelines, and personal clinical experiences. Most of
      the available evidence in this area of care is from expert opinion or published
      consensus statements (level III). MAIN MESSAGE: Adults with DD have complex
      health issues, many of them differing from those of the general population. Good 
      primary care identifies the particular health issues faced by adults with DD to
      improve their quality of life, to improve their access to health care, and to
      prevent suffering, morbidity, and premature death. These guidelines synthesize
      general, physical, behavioural, and mental health issues of adults with DD that
      primary care providers should be aware of, and they present recommendations for
      screening and management based on current knowledge that practitioners can apply.
      Because of interacting biologic, psychoaffective, and social factors that
      contribute to the health and well-being of adults with DD, these guidelines
      emphasize involving caregivers, adapting procedures when appropriate, and seeking
      input from a range of health professionals when available. Ethical care is also
      emphasized. The guidelines are formulated within an ethical framework that pays
      attention to issues such as informed consent and the assessment of health
      benefits in relation to risks of harm. CONCLUSION: Implementation of the
      guidelines proposed here would improve the health of adults with DD and would
      minimize disparities in health and health care between adults with DD and those
      in the general population.
FAU - Sullivan, William F
AU  - Sullivan WF
AD  - St Michael's Hospital, Toronto, Ont. bill.sullivan@surreyplace.on.ca
FAU - Berg, Joseph M
AU  - Berg JM
FAU - Bradley, Elspeth
AU  - Bradley E
FAU - Cheetham, Tom
AU  - Cheetham T
FAU - Denton, Richard
AU  - Denton R
FAU - Heng, John
AU  - Heng J
FAU - Hennen, Brian
AU  - Hennen B
FAU - Joyce, David
AU  - Joyce D
FAU - Kelly, Maureen
AU  - Kelly M
FAU - Korossy, Marika
AU  - Korossy M
FAU - Lunsky, Yona
AU  - Lunsky Y
FAU - McMillan, Shirley
AU  - McMillan S
CN  - Colloquium on Guidelines for the Primary Health Care of Adults with Developmental
      Disabilities
LA  - eng
LA  - fre
PT  - Consensus Development Conference
PT  - Journal Article
PT  - Practice Guideline
PT  - Research Support, Non-U.S. Gov't
PL  - Canada
TA  - Can Fam Physician
JT  - Canadian family physician Medecin de famille canadien
JID - 0120300
SB  - IM
MH  - Adult
MH  - Canada
MH  - *Developmental Disabilities/therapy
MH  - Humans
MH  - *Primary Health Care
PMC - PMC3093586
EDAT- 2011/05/17 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/05/17 06:00
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - 57/5/541 [pii]
PST - ppublish
SO  - Can Fam Physician. 2011 May;57(5):541-53, e154-68.


PMID- 21571712
OWN - NLM
STAT- MEDLINE
DCOM- 20110929
LR  - 20211020
IS  - 1715-5258 (Electronic)
IS  - 0008-350X (Linking)
VI  - 57
IP  - 5
DP  - 2011 May
TI  - Opioid prescribing--a matter of ethics.
PG  - 531-2; discussion 532; author reply 537-9
FAU - Pakes, Barry N
AU  - Pakes BN
LA  - eng
PT  - Comment
PT  - Letter
PL  - Canada
TA  - Can Fam Physician
JT  - Canadian family physician Medecin de famille canadien
JID - 0120300
RN  - 0 (Analgesics, Opioid)
SB  - IM
CON - Can Fam Physician. 2011 Mar;57(3):e92-6. PMID: 21402956
MH  - Analgesics, Opioid/adverse effects/*therapeutic use
MH  - Family Practice/ethics
MH  - Humans
MH  - Inappropriate Prescribing/adverse effects/*ethics
PMC - PMC3093579
EDAT- 2011/05/17 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/05/17 06:00
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - 57/5/531 [pii]
PST - ppublish
SO  - Can Fam Physician. 2011 May;57(5):531-2; discussion 532; author reply 537-9.


PMID- 21571405
OWN - NLM
STAT- MEDLINE
DCOM- 20120608
LR  - 20151119
IS  - 1532-2793 (Electronic)
IS  - 0260-6917 (Linking)
VI  - 32
IP  - 3
DP  - 2012 Apr
TI  - Construction and testing of the Moral Development Scale for Professionals (MDSP).
PG  - 255-60
LID - 10.1016/j.nedt.2011.04.002 [doi]
AB  - Moral development among students is central for nursing education, because
      nursing is informed by moral ends, and it is essential that professional nurses
      have a well developed ability for moral behaviour, ethical reasoning and decision
      making. The aim of this study was to construct a new instrument for measuring
      moral development according to Kohlberg's theory of moral development among
      students and professionals, and initially test it for reliability and validity
      among students in professional education. Thirty-two items following the
      conventional and postconventional stages in the theory were developed. Different 
      actions for reducing the items were implemented. The final version of the
      instrument with 12 items was tested for reliability and validity among 326
      conveniently chosen students. A Cronbach's alpha coefficient of 0.67 and support 
      for construct validity was obtained.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Skisland, Anne
AU  - Skisland A
AD  - Department of Health and Nursing Sciences, University of Agder, Kristiansand and 
      Grimstad, Norway. anne.skisland@uia.no
FAU - Bjornestad, John Olav
AU  - Bjornestad JO
FAU - Soderhamn, Olle
AU  - Soderhamn O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110514
PL  - Scotland
TA  - Nurse Educ Today
JT  - Nurse education today
JID - 8511379
MH  - Adolescent
MH  - Adult
MH  - *Ethics, Nursing
MH  - Female
MH  - Humans
MH  - Male
MH  - *Moral Development
MH  - Nursing Education Research
MH  - Nursing Methodology Research
MH  - Nursing Theory
MH  - Psychometrics
MH  - Reproducibility of Results
MH  - Students, Nursing/*psychology
MH  - *Surveys and Questionnaires
MH  - Young Adult
EDAT- 2011/05/17 06:00
MHDA- 2012/06/09 06:00
CRDT- 2011/05/17 06:00
PHST- 2010/11/17 00:00 [received]
PHST- 2011/03/20 00:00 [revised]
PHST- 2011/04/05 00:00 [accepted]
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2012/06/09 06:00 [medline]
AID - S0260-6917(11)00084-0 [pii]
AID - 10.1016/j.nedt.2011.04.002 [doi]
PST - ppublish
SO  - Nurse Educ Today. 2012 Apr;32(3):255-60. doi: 10.1016/j.nedt.2011.04.002. Epub
      2011 May 14.


PMID- 21571338
OWN - NLM
STAT- MEDLINE
DCOM- 20110817
LR  - 20220410
IS  - 1527-3792 (Electronic)
IS  - 0022-5347 (Linking)
VI  - 186
IP  - 1
DP  - 2011 Jul
TI  - Effectiveness of procedural simulation in urology: a systematic review.
PG  - 26-34
LID - 10.1016/j.juro.2011.02.2684 [doi]
AB  - PURPOSE: We analyzed studies validating the effectiveness and deficiencies of
      simulation for training and assessment in urology. We documented simulation types
      (synthetic, virtual reality and animal models), participant experience level and 
      tasks performed. The feasibility, validity, cost-effectiveness, reliability and
      educational impact of the simulators were also evaluated. MATERIALS AND METHODS: 
      The MEDLINE(R), EMBASE and PsycINFO(R) databases were systematically searched
      until September 2010. References from retrieved articles were reviewed to broaden
      the search. RESULTS: The study included case reports, case series and empirical
      studies of training and assessment in urology using procedural simulation. The
      model name, training tasks, participant level, training duration and evaluation
      scoring were extracted from each study. We also extracted data on face, content
      and construct validity. Most studies suitably addressed content, construct and
      face validation as well as the feasibility, educational impact and
      cost-effectiveness of simulation models. Synthetic, animal and virtual reality
      models were demonstrated to be effective training and assessment tools for junior
      trainees. Few investigators looked at the transferability of skills from
      simulation to real patients. CONCLUSIONS: Current simulation models are valid and
      reliable for the initial phase of training and assessment. For advanced and
      specialist level skill acquisition animal models can be used but availability is 
      limited due to supply shortages and ethical restrictions. More research is needed
      to validate simulated environments for senior trainees and specialists.
CI  - Copyright (c) 2011 American Urological Association Education and Research, Inc.
      Published by Elsevier Inc. All rights reserved.
FAU - Ahmed, Kamran
AU  - Ahmed K
AD  - Medical Research Council Centre for Transplantation, King's College London,
      King's Health Partners, Guy's Hospital, London, United Kingdom.
      k.ahmed@imperial.ac.uk
FAU - Jawad, Muhammed
AU  - Jawad M
FAU - Abboudi, May
AU  - Abboudi M
FAU - Gavazzi, Andrea
AU  - Gavazzi A
FAU - Darzi, Ara
AU  - Darzi A
FAU - Athanasiou, Thanos
AU  - Athanasiou T
FAU - Vale, Justin
AU  - Vale J
FAU - Khan, Mohammad Shamim
AU  - Khan MS
FAU - Dasgupta, Prokar
AU  - Dasgupta P
LA  - eng
GR  - Department of Health/United Kingdom
GR  - Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20110514
PL  - United States
TA  - J Urol
JT  - The Journal of urology
JID - 0376374
SB  - IM
MH  - Cadaver
MH  - Computer Simulation
MH  - Education, Medical/*methods
MH  - Models, Anatomic
MH  - Models, Animal
MH  - Urology/*education
EDAT- 2011/05/17 06:00
MHDA- 2011/08/19 06:00
CRDT- 2011/05/17 06:00
PHST- 2010/08/03 00:00 [received]
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2011/08/19 06:00 [medline]
AID - S0022-5347(11)03178-8 [pii]
AID - 10.1016/j.juro.2011.02.2684 [doi]
PST - ppublish
SO  - J Urol. 2011 Jul;186(1):26-34. doi: 10.1016/j.juro.2011.02.2684. Epub 2011 May
      14.


PMID- 21569591
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1478-4505 (Electronic)
IS  - 1478-4505 (Linking)
VI  - 9
DP  - 2011 May 14
TI  - Collaborating with consumer and community representatives in health and medical
      research in Australia: results from an evaluation.
PG  - 18
LID - 10.1186/1478-4505-9-18 [doi]
AB  - OBJECTIVE: To collaborate with consumer and community representatives in the
      Alcohol and Pregnancy Project from 2006-2008
      http://www.ichr.uwa.edu.au/alcoholandpregnancy and evaluate researchers' and
      consumer and community representatives' perceptions of the process, context and
      impact of consumer and community participation in the project. METHODS: We formed
      two reference groups and sought consumer and community representatives'
      perspectives on all aspects of the project over a three year period. We developed
      an evaluation framework and asked consumer and community representatives and
      researchers to complete a self-administered questionnaire at the end of the
      project. RESULTS: Fifteen researchers (93.8%) and seven (53.8%) consumer and
      community representatives completed a questionnaire. Most consumer and community 
      representatives agreed that the process and context measures of their
      participation had been achieved. Both researchers and consumer and community
      representatives identified areas for improvement and offered suggestions how
      these could be improved for future research. Researchers thought consumer and
      community participation contributed to project outputs and outcomes by enhancing 
      scientific and ethical standards, providing legitimacy and authority, and
      increasing the project's credibility and participation. They saw it was
      fundamental to the research process and acknowledged consumer and community
      representatives for their excellent contribution. Consumer and community
      representatives were able to directly influence decisions about the research.
      They thought that consumer and community participation had significant influence 
      on the success of project outputs and outcomes. CONCLUSIONS: Consumer and
      community participation is an essential component of good research practice and
      contributed to the Alcohol and Pregnancy Project by enhancing research processes,
      outputs and outcomes, and this participation was valued by community and consumer
      representatives and researchers. The National Health and Medical Research Council
      in Australia expects researchers to work in partnership and involve consumer and 
      community representatives in health and medical research, and to evaluate
      community and consumer participation. It is important to demonstrate whether
      consumer and community participation makes a difference to health and medical
      research.
FAU - Payne, Janet M
AU  - Payne JM
AD  - Telethon Institute for Child Health Research, Centre for Child Health Research,
      The University of Western Australia, Subiaco, Western Australia.
      janp@ichr.uwa.edu.au.
FAU - D'Antoine, Heather A
AU  - D'Antoine HA
FAU - France, Kathryn E
AU  - France KE
FAU - McKenzie, Anne E
AU  - McKenzie AE
FAU - Henley, Nadine
AU  - Henley N
FAU - Bartu, Anne E
AU  - Bartu AE
FAU - Elliott, Elizabeth J
AU  - Elliott EJ
FAU - Bower, Carol
AU  - Bower C
LA  - eng
PT  - Journal Article
DEP - 20110514
PL  - England
TA  - Health Res Policy Syst
JT  - Health research policy and systems
JID - 101170481
PMC - PMC3118959
EDAT- 2011/05/17 06:00
MHDA- 2011/05/17 06:01
CRDT- 2011/05/17 06:00
PHST- 2010/12/20 00:00 [received]
PHST- 2011/05/14 00:00 [accepted]
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2011/05/17 06:01 [medline]
AID - 1478-4505-9-18 [pii]
AID - 10.1186/1478-4505-9-18 [doi]
PST - epublish
SO  - Health Res Policy Syst. 2011 May 14;9:18. doi: 10.1186/1478-4505-9-18.


PMID- 21569349
OWN - NLM
STAT- MEDLINE
DCOM- 20110916
LR  - 20211020
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 12
DP  - 2011 May 11
TI  - Does clinical equipoise apply to cluster randomized trials in health research?
PG  - 118
LID - 10.1186/1745-6215-12-118 [doi]
AB  - This article is part of a series of papers examining ethical issues in cluster
      randomized trials (CRTs) in health research. In the introductory paper in this
      series, Weijer and colleagues set out six areas of inquiry that must be addressed
      if the cluster trial is to be set on a firm ethical foundation. This paper
      addresses the third of the questions posed, namely, does clinical equipoise apply
      to CRTs in health research? The ethical principle of beneficence is the moral
      obligation not to harm needlessly and, when possible, to promote the welfare of
      research subjects. Two related ethical problems have been discussed in the CRT
      literature. First, are control groups that receive only usual care unduly
      disadvantaged? Second, when accumulating data suggests the superiority of one
      intervention in a trial, is there an ethical obligation to act?In individually
      randomized trials involving patients, similar questions are addressed by the
      concept of clinical equipoise, that is, the ethical requirement that, at the
      start of a trial, there be a state of honest, professional disagreement in the
      community of expert practitioners as to the preferred treatment. Since CRTs may
      not involve physician-researchers and patient-subjects, the applicability of
      clinical equipoise to CRTs is uncertain. Here we argue that clinical equipoise
      may be usefully grounded in a trust relationship between the state and research
      subjects, and, as a result, clinical equipoise is applicable to CRTs. Clinical
      equipoise is used to argue that control groups receiving only usual care are not 
      disadvantaged so long as the evidence supporting the experimental and control
      interventions is such that experts would disagree as to which is preferred.
      Further, while data accumulating during the course of a CRT may favor one
      intervention over another, clinical equipoise supports continuing the trial until
      the results are likely to be broadly convincing, often coinciding with the
      planned completion of the trial. Finally, clinical equipoise provides research
      ethics committees with formal and procedural guidelines that form an important
      part of the assessment of the benefits and harms of CRTs in health research.
FAU - Binik, Ariella
AU  - Binik A
AD  - Rotman Institute of Philosophy, Department of Philosophy, University of Western
      Ontario, London, ON, N6A 5B8, Canada.
FAU - Weijer, Charles
AU  - Weijer C
FAU - McRae, Andrew D
AU  - McRae AD
FAU - Grimshaw, Jeremy M
AU  - Grimshaw JM
FAU - Boruch, Robert
AU  - Boruch R
FAU - Brehaut, Jamie C
AU  - Brehaut JC
FAU - Donner, Allan
AU  - Donner A
FAU - Eccles, Martin P
AU  - Eccles MP
FAU - Saginur, Raphael
AU  - Saginur R
FAU - Taljaard, Monica
AU  - Taljaard M
FAU - Zwarenstein, Merrick
AU  - Zwarenstein M
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110511
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
SB  - IM
MH  - *Cluster Analysis
MH  - Evidence-Based Medicine/*ethics/statistics & numerical data
MH  - Humans
MH  - Moral Obligations
MH  - Patient Rights
MH  - Patient Selection/ethics
MH  - Randomized Controlled Trials as Topic/ethics/statistics & numerical data
MH  - *Research Design/statistics & numerical data
MH  - Risk Assessment
MH  - *Therapeutic Equipoise
MH  - Trust
PMC - PMC3113987
EDAT- 2011/05/17 06:00
MHDA- 2011/09/17 06:00
CRDT- 2011/05/17 06:00
PHST- 2010/09/30 00:00 [received]
PHST- 2011/05/11 00:00 [accepted]
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2011/09/17 06:00 [medline]
AID - 1745-6215-12-118 [pii]
AID - 10.1186/1745-6215-12-118 [doi]
PST - epublish
SO  - Trials. 2011 May 11;12:118. doi: 10.1186/1745-6215-12-118.


PMID- 21569295
OWN - NLM
STAT- MEDLINE
DCOM- 20110725
LR  - 20211020
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 12
DP  - 2011 May 11
TI  - Feeling trapped and being torn: physicians' narratives about ethical dilemmas in 
      hemodialysis care that evoke a troubled conscience.
PG  - 8
LID - 10.1186/1472-6939-12-8 [doi]
AB  - BACKGROUND: This study is part of a major study about difficulties in
      communicating ethical problems within and among professional groups working in
      hemodialysis care. Describing experiences of ethically difficult situations that 
      induce a troubled conscience may raise consciousness about ethical problems and
      thereby open the way to further reflection.The aim of this study was to
      illuminate the meanings of being in ethically difficult situations that led to
      the burden of a troubled conscience, as narrated by physicians working in
      dialysis care. METHOD: A phenomenological hermeneutic method was used to analyze 
      the transcribed narrative interviews with five physicians who had varying lengths
      of experience in nephrology. RESULTS: The analysis shows that physicians working 
      in hemodialysis care suffered from a troubled conscience when they felt torn by
      conflicting demands and trapped in irresolution. They faced ethical dilemmas
      where they were forced to make crucial decisions about life or death, or to
      prioritize when squeezed between time restraints and professional and personal
      demands. In these ethical dilemmas the physicians avoided arousing conflicts,
      were afraid of using their authority, were burdened by moral responsibility and
      felt devalued and questioned about their way of handling the situation. The
      findings point to another way of encountering ethical dilemmas, being guided by
      their conscience. This mean sharing the agony of deciding how to act, being brave
      enough to bring up the crucial problem, feeling certain that better ways of
      acting have not been overlooked, being respected and confirmed regarding
      decisions made. CONCLUSION: The meanings of being in ethically difficult
      situations that led to the burden of a troubled conscience in those working in
      hemodialysis care, indicate the importance of increasing the level of
      communication within and among various professional groups--to transform being
      burdened by a troubled conscience into using conscience as a guide--in situations
      where no way of solving the problem seems to be good.
FAU - Gronlund, Catarina E C Fischer
AU  - Gronlund CE
AD  - Department of Nursing, Umea University, 901 87 Umea, Sweden.
      catarina.fischer.gronlund@nurs.umu.se
FAU - Dahlqvist, Vera
AU  - Dahlqvist V
FAU - Soderberg, Anna I S
AU  - Soderberg AI
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110511
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Adult
MH  - Choice Behavior/ethics
MH  - *Conflict, Psychological
MH  - *Conscience
MH  - Decision Making/*ethics
MH  - Family
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Moral Obligations
MH  - *Narration
MH  - Nephrology/ethics
MH  - Nurses
MH  - Patient Participation
MH  - Physicians/*ethics/psychology
MH  - Practice Guidelines as Topic
MH  - Renal Dialysis/*ethics/nursing
MH  - Sweden
MH  - Tape Recording
MH  - Uncertainty
MH  - Withholding Treatment/*ethics
MH  - Workforce
PMC - PMC3104380
EDAT- 2011/05/17 06:00
MHDA- 2011/07/26 06:00
CRDT- 2011/05/17 06:00
PHST- 2010/11/20 00:00 [received]
PHST- 2011/05/11 00:00 [accepted]
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2011/07/26 06:00 [medline]
AID - 1472-6939-12-8 [pii]
AID - 10.1186/1472-6939-12-8 [doi]
PST - epublish
SO  - BMC Med Ethics. 2011 May 11;12:8. doi: 10.1186/1472-6939-12-8.


PMID- 21569244
OWN - NLM
STAT- MEDLINE
DCOM- 20111031
LR  - 20211020
IS  - 1747-5341 (Electronic)
IS  - 1747-5341 (Linking)
VI  - 6
DP  - 2011 May 10
TI  - Should we treat depression with drugs or psychological interventions? A reply to 
      Ioannidis.
PG  - 8
LID - 10.1186/1747-5341-6-8 [doi]
AB  - We reply to the Ioannidis's paper "Effectiveness of antidepressants; an evidence 
      based myth constructed from a thousand controlled trials." We disagree that
      antidepressants have no greater efficacy than placebo. We present the efficacy
      from hundreds of trials in terms of the percentage of patients with a substantial
      clinical response (a 50% improvement or more symptomatic reduction). This
      meta-analysis finds that 42-70% of depressed patients improve with drug and
      21%-39% improve with placebo. The response benefit of antidepressant treatment is
      33%-11% greater than placebo. Ioannidis argues that it would be vanishingly
      smaller because systematic biasing in these clinical trials would reduce the
      drug-placebo difference to zero. Ioannidis' argument that antidepressants have no
      benefit is eroded by his failures of logic because he does not present any
      evidence that there are a large number of studies where placebo is substantially 
      more effective than drug. (To reduce to zero, one would also have to show that
      some of the unpublished studies find placebo better than drug and have
      substantial systematic or methodological bias). We also present the empirical
      evidence showing that these methodological concerns generally have the opposite
      effect of what Ioannidis argues, supporting our contention that the measured
      efficacy of antidepressants likely underestimates true efficacy. Our most
      important criticism is Ioannidis' basic underlying argument about antidepressants
      that if the existing evidence is imperfect and methods can be criticized, then
      this proves that antidepressant are not efficacious. He presents no credible
      evidence that antidepressants have zero effect size. Valid arguments can point
      out difficulties with the data but do not prove that a given drug had no
      efficacy. Indeed better evidence might prove it was more efficacious that
      originally found. We find no empirical or ethical reason why psychiatrists should
      not try to help depressed patients with drugs and/or with
      psychotherapeutic/behavioral treatments given evidence of efficacy even though
      our treatment knowledge has limitations. The immense suffering of patients with
      major depression leads to ethical, moral, professional and legal obligations to
      treat patients with the best available tools at our disposal, while diligently
      and actively monitoring for adverse effects and actively revising treatment
      components as necessary.
FAU - Davis, John M
AU  - Davis JM
AD  - Psychiatric Institute, Department of Psychiatry, University of Illinois at
      Chicago, Chicago, IL, USA. JDavis@Psych.uic.edu
FAU - Giakas, William J
AU  - Giakas WJ
FAU - Qu, Jie
AU  - Qu J
FAU - Prasad, Pavan
AU  - Prasad P
FAU - Leucht, Stefan
AU  - Leucht S
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20110510
PL  - England
TA  - Philos Ethics Humanit Med
JT  - Philosophy, ethics, and humanities in medicine : PEHM
JID - 101258058
RN  - 0 (Antidepressive Agents)
SB  - IM
CON - Philos Ethics Humanit Med. 2008;3:14. PMID: 18505564
MH  - Antidepressive Agents/*therapeutic use
MH  - Depressive Disorder, Major/*drug therapy
MH  - Drug Approval/*statistics & numerical data
MH  - Evidence-Based Medicine/*methods
MH  - Humans
MH  - *Meta-Analysis as Topic
MH  - *Randomized Controlled Trials as Topic
PMC - PMC3123637
EDAT- 2011/05/17 06:00
MHDA- 2011/11/01 06:00
CRDT- 2011/05/17 06:00
PHST- 2010/04/12 00:00 [received]
PHST- 2011/05/10 00:00 [accepted]
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2011/11/01 06:00 [medline]
AID - 1747-5341-6-8 [pii]
AID - 10.1186/1747-5341-6-8 [doi]
PST - epublish
SO  - Philos Ethics Humanit Med. 2011 May 10;6:8. doi: 10.1186/1747-5341-6-8.


PMID- 21569237
OWN - NLM
STAT- MEDLINE
DCOM- 20110916
LR  - 20211020
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 12
DP  - 2011 May 10
TI  - Cluster randomised trial in the General Practice Research Database: 1. Electronic
      decision support to reduce antibiotic prescribing in primary care (eCRT study).
PG  - 115
LID - 10.1186/1745-6215-12-115 [doi]
AB  - BACKGROUND: The purpose of this research is to develop and evaluate methods for
      conducting cluster randomised trials in a primary care database that contains
      electronic patient records for large numbers of family practices. Cluster
      randomised trials are trials in which the units allocated represent groups of
      individuals, in this case family practices and their registered patients. Cluster
      randomised trials often suffer from the limitation that they include too few
      clusters, leading to problems of insufficient power and only imprecise estimation
      of the intraclass correlation coefficient, a key design parameter. This
      difficulty might be overcome by utilising databases that already hold electronic 
      patient records for large numbers of practices. The protocol describes one
      application: a study of antibiotic prescribing for acute respiratory infection; a
      second protocol outlines an intervention in a less frequent chronic condition of 
      public health importance, stroke. METHODS/DESIGN: The objective of the study is
      to implement a cluster randomised trial to test the effectiveness of an
      electronic record-based intervention at achieving a reduction in antibiotic
      prescribing at consultations for respiratory illness in patients aged 18 and 59
      years old in intervention family practices as compared with controls. Family
      practices will be recruited from the practices that presently contribute data to 
      the UK General Practice Research Database (GPRD). Following randomisation,
      electronic prompts will be installed remotely at intervention practices to
      promote adherence with evidence-based standards of medical practice. The
      intervention was developed through qualitative research at non-intervention
      practices. Data for outcome assessment will be obtained from anonymised
      electronic patient records that are routinely collected into GPRD. This protocol 
      outlines the proposed study designs, data sources, sample size requirements,
      analysis methods and dissemination plans. Ethical issues are also discussed.
      DISCUSSION: Results from this study will provide methodological evidence
      concerning the use of electronic patient records and databases for implementing
      cluster randomised trials in primary care. The study will also provide
      substantive findings in respect of electronic record-based interventions to
      reduce antibiotic prescribing in primary care. TRIAL REGISTRATION: Current
      Controlled Trials ISRCTN 47558792.
FAU - Gulliford, Martin C
AU  - Gulliford MC
AD  - Primary Care and Public Health Sciences, King's College London, UK.
      martin.gulliford@kcl.ac.uk
FAU - van Staa, Tjeerd
AU  - van Staa T
FAU - McDermott, Lisa
AU  - McDermott L
FAU - Dregan, Alex
AU  - Dregan A
FAU - McCann, Gerard
AU  - McCann G
FAU - Ashworth, Mark
AU  - Ashworth M
FAU - Charlton, Judith
AU  - Charlton J
FAU - Grieve, Andrew P
AU  - Grieve AP
FAU - Little, Paul
AU  - Little P
FAU - Moore, Michael V
AU  - Moore MV
FAU - Yardley, Lucy
AU  - Yardley L
CN  - electronic Cluster Randomised Trial Research Team eCRT Research Team
LA  - eng
SI  - ISRCTN/ISRCTN47558792
GR  - RP-PG-0407-10184/DH_/Department of Health/United Kingdom
GR  - WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110510
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Anti-Bacterial Agents/*therapeutic use
MH  - *Cluster Analysis
MH  - Databases as Topic
MH  - *Decision Support Systems, Clinical
MH  - Evidence-Based Medicine
MH  - *General Practice
MH  - Guideline Adherence
MH  - *Health Records, Personal
MH  - Humans
MH  - Middle Aged
MH  - Practice Guidelines as Topic
MH  - *Practice Patterns, Physicians'
MH  - *Primary Health Care
MH  - Referral and Consultation
MH  - *Reminder Systems
MH  - *Research Design
MH  - Respiration Disorders/diagnosis/*drug therapy
MH  - United Kingdom
MH  - Young Adult
PMC - PMC3101122
IR  - Delaney B
FIR - Delaney, Brendan
IR  - Taweel A
FIR - Taweel, Adel
IR  - Rudd A
FIR - Rudd, Anthony
IR  - Wolfe C
FIR - Wolfe, Charles
EDAT- 2011/05/17 06:00
MHDA- 2011/09/17 06:00
CRDT- 2011/05/17 06:00
PHST- 2011/03/09 00:00 [received]
PHST- 2011/05/10 00:00 [accepted]
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2011/09/17 06:00 [medline]
AID - 1745-6215-12-115 [pii]
AID - 10.1186/1745-6215-12-115 [doi]
PST - epublish
SO  - Trials. 2011 May 10;12:115. doi: 10.1186/1745-6215-12-115.


PMID- 21569145
OWN - NLM
STAT- MEDLINE
DCOM- 20110923
LR  - 20120910
IS  - 1365-2834 (Electronic)
IS  - 0966-0429 (Linking)
VI  - 19
IP  - 4
DP  - 2011 May
TI  - Leadership and management in mental health nursing.
PG  - 487-97
LID - 10.1111/j.1365-2834.2011.01237.x [doi]
AB  - BACKGROUND: Mental health nurses are agents of change, and their leadership,
      management role and characteristics exist at many levels in health care. Previous
      research presents a picture of mental health nurses as subordinate and passive
      recipients of the leader's influence and regard leadership and management as
      distinct from the nurses' practical work. AIM: The aim was to provide a synthesis
      of the studies conducted and to discuss the relationship between nursing
      leadership and nursing management in the context of mental health nursing.
      METHOD: A literature search was conducted using EBSCO-host, Academic Search
      Premier, Science Direct, CINAHL and PubMed for the period January 1995-July 2010.
      RESULTS: Leadership and management in the context of mental health nursing are
      human activities that imply entering into mutual relationships. CONCLUSION:
      Mental health nurses' leadership, management and transformational leadership are 
      positively related in terms of effectiveness and nurses' skills. IMPLICATION FOR 
      NURSING MANAGEMENT: It is important to consider mental health nurses' management 
      as a form of leadership similar to or as a natural consequence of
      transformational leadership (TL) and that ethical concerns must be constantly
      prioritized throughout every level of the organization.
CI  - (c) 2011 The Authors. Journal compilation (c) 2011 Blackwell Publishing Ltd.
FAU - Blegen, Nina Elisabeth
AU  - Blegen NE
AD  - Centre for Women's, Family and Child Health, Vestfold University College,
      Tonsberg, University of Stavanger, Norway. nina.blegen@hive.no
FAU - Severinsson, Elisabeth
AU  - Severinsson E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110406
PL  - England
TA  - J Nurs Manag
JT  - Journal of nursing management
JID - 9306050
MH  - Community Mental Health Services/*organization & administration
MH  - Humans
MH  - *Leadership
MH  - Mental Disorders/*nursing
MH  - Models, Psychological
MH  - Norway
MH  - Nursing, Supervisory
MH  - Psychiatric Nursing/*organization & administration
MH  - Psychological Theory
EDAT- 2011/05/17 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/05/17 06:00
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 10.1111/j.1365-2834.2011.01237.x [doi]
PST - ppublish
SO  - J Nurs Manag. 2011 May;19(4):487-97. doi: 10.1111/j.1365-2834.2011.01237.x. Epub 
      2011 Apr 6.


PMID- 21568680
OWN - NLM
STAT- MEDLINE
DCOM- 20111031
LR  - 20151119
IS  - 1744-8301 (Electronic)
IS  - 1479-6694 (Linking)
VI  - 7
IP  - 5
DP  - 2011 May
TI  - Improving oncology outcomes through targeted therapeutics will require electronic
      delivery systems.
PG  - 649-56
LID - 10.2217/fon.11.37 [doi]
AB  - Typically, chemotherapy selection takes into account patient demographic data,
      including disease symptoms, family history, environmental factors and concurrent 
      medications. Although validated and approved genomics tests are available for
      targeted therapeutics, a major challenge facing healthcare is the ability to
      process the genomic data in the patient's context and to return clinically
      interpretable dosing guidance to the physician in a realistic time frame.
      Delivery of these targeted therapeutics, made possible by clinical decision
      support systems connected to an electronic health record may help drive both the 
      acceptance and adaptation of an electronic health record system, as well as
      provide personalized information at point-of-care, as part of the routine
      workflow. The realization of targeted therapeutics will depend on the concerted
      efforts of stakeholder groups as they address political, ethical, socioeconomical
      and technical challenges to achieve personalized medicine adoption through
      real-world implementation.
FAU - van Rooij, Tibor
AU  - van Rooij T
AD  - Faculty of Pharmacy & Pharmaceutical Sciences, 3126 Dentistry/Pharmacy Centre,
      University of Alberta, Edmonton, AB T6G 2N8, Canada.
FAU - Marsh, Sharon
AU  - Marsh S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Future Oncol
JT  - Future oncology (London, England)
JID - 101256629
SB  - IM
MH  - *Drug Delivery Systems
MH  - *Electronic Health Records
MH  - Humans
MH  - *Molecular Targeted Therapy
MH  - Neoplasms/*drug therapy/pathology
MH  - Precision Medicine
MH  - Treatment Outcome
EDAT- 2011/05/17 06:00
MHDA- 2011/11/01 06:00
CRDT- 2011/05/17 06:00
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2011/11/01 06:00 [medline]
AID - 10.2217/fon.11.37 [doi]
PST - ppublish
SO  - Future Oncol. 2011 May;7(5):649-56. doi: 10.2217/fon.11.37.


PMID- 21568114
OWN - NLM
STAT- MEDLINE
DCOM- 20110719
LR  - 20110513
IS  - 0297-2964 (Print)
IS  - 0297-2964 (Linking)
IP  - 104
DP  - 2011 Mar
TI  - [A anthropological critique of the ethic of care].
PG  - 5-22
AB  - This article is a critique of the anthropology of vulnerability and of the needs 
      on which the ethics of care are based. Firstly, this critique confronts the
      universal postulate of the anthropology of vulnerability to the history of the
      anthropology of illness. The latter manages to build up a specific disciplinary
      field in refusing the supervision of the medical sciences and the implicit
      principle to consider illness as an universal fact. The paper refers to the
      anthropology of nature and Philippe Descola's work in order to develop a
      comparative study of the systems of representations, including the naturalism of 
      biomedicine as a model among others. It then presents the descriptions of the
      representations of vulnerability and the needs which are linked to the four main 
      ontologies defined by anthropology of nature, animism, totemism, analogy and
      naturalism, and gives a new light to the anthropology on which the ethics of care
      rest. That anthropology of vulnerability could be an involuntary factor in order 
      to make societies conform to an hygienic constraint. The ethics of care would
      therefore benefit greatly in freeing themselves from anthropology of
      vulnerability and focus on their original contextualism; in particular, they
      would benefit of the knowledge of the limits of naturalism at their basis. It
      will also allow them to provide a new tool for engineering social transformations
      in a time, the beginning of XXI century, when cultures happen to mix.
FAU - Bertrand, Alienor
AU  - Bertrand A
AD  - CNRS UMR 5 037.
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Une critique anthropologique de l'ethique du soin.
PL  - France
TA  - Rech Soins Infirm
JT  - Recherche en soins infirmiers
JID - 9715370
MH  - *Anthropology
MH  - *Ethics, Nursing
MH  - Humans
MH  - Philosophy, Nursing
EDAT- 2011/05/17 06:00
MHDA- 2011/07/20 06:00
CRDT- 2011/05/17 06:00
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2011/07/20 06:00 [medline]
PST - ppublish
SO  - Rech Soins Infirm. 2011 Mar;(104):5-22.


PMID- 21568107
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20110513
IS  - 0012-7183 (Print)
IS  - 0012-7183 (Linking)
VI  - 127
IP  - 8
DP  - 2011
TI  - [Euthanasia].
PG  - 793-9
AB  - Clinical practice may pose an ethical dilemma: is it better to actively kill a
      patient or let her/him die naturally and more slowly? The former may be
      considered to involve less suffering than a slow death possibly full of
      suffering. The central problem in respect of euthanasia is how to define, which
      level of suffering is intolerable. In practice, persons suffering particularly
      from degenerative and chronic neurological diseases experience helplessness and
      powerlessness as a burden. The scope of suffering is changing over time, whereby 
      the establishment of permanent guidelines for euthanasia is difficult.
FAU - Hanninen, Juha
AU  - Hanninen J
AD  - Terhokoti, Helsinki.
LA  - fin
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Eutanasia.
PL  - Finland
TA  - Duodecim
JT  - Duodecim; laaketieteellinen aikakauskirja
JID - 0373207
SB  - IM
MH  - Ethics, Medical
MH  - Euthanasia/*ethics
MH  - Humans
MH  - Nervous System Diseases/*pathology
MH  - Practice Guidelines as Topic
MH  - Stress, Psychological
EDAT- 2011/05/17 06:00
MHDA- 2011/06/29 06:00
CRDT- 2011/05/17 06:00
PHST- 2011/05/17 06:00 [entrez]
PHST- 2011/05/17 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
PST - ppublish
SO  - Duodecim. 2011;127(8):793-9.


PMID- 21567986
OWN - NLM
STAT- MEDLINE
DCOM- 20111222
LR  - 20220408
IS  - 1939-3806 (Electronic)
IS  - 1939-3806 (Linking)
VI  - 4
IP  - 4
DP  - 2011 Aug
TI  - Bridging autism, science and society: moving toward an ethically informed
      approach to autism research.
PG  - 271-82
LID - 10.1002/aur.201 [doi]
AB  - Recent developments in the science of autism have provoked widespread unease
      among autism activists. Drawing on the findings of a major international
      gathering of researchers, ethicists, and activists, this paper presents the first
      major analysis of the ethical questions arising from this unease. We outline the 
      scientific developments that have provoked the most discomfort, analyze the
      response to these developments from within and without the autism community, and 
      trace the current state of the ethical debate. Having done so, we contend that
      these ethical questions are unlikely to be resolved as they depend on
      fundamentally conflicting assumptions about the nature and desirability of
      neurocognitive difference. We conclude by arguing for a new range of democratic
      mechanisms that could enable the scientific community, autistics, and other
      concerned parties to respond collectively to such entrenched ethical disputes.
CI  - Copyright (c) 2011, International Society for Autism Research, Wiley-Liss, Inc.
FAU - Pellicano, Elizabeth
AU  - Pellicano E
AD  - Centre for Research in Autism and Education, Department of Psychology and Human
      Development, Institute of Education, London, UK. l.pellicano@ioe.ac.uk
FAU - Stears, Marc
AU  - Stears M
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110512
PL  - United States
TA  - Autism Res
JT  - Autism research : official journal of the International Society for Autism
      Research
JID - 101461858
SB  - IM
MH  - *Autistic Disorder
MH  - *Ethics, Research
MH  - Genetic Research/ethics
MH  - Genetic Testing/ethics
MH  - Humans
MH  - Morals
MH  - Neurobiology/ethics
MH  - Neurochemistry/ethics
MH  - Patient Advocacy/*ethics
MH  - Science/*ethics
EDAT- 2011/05/14 06:00
MHDA- 2011/12/23 06:00
CRDT- 2011/05/14 06:00
PHST- 2010/10/15 00:00 [received]
PHST- 2011/04/01 00:00 [accepted]
PHST- 2011/05/14 06:00 [entrez]
PHST- 2011/05/14 06:00 [pubmed]
PHST- 2011/12/23 06:00 [medline]
AID - 10.1002/aur.201 [doi]
PST - ppublish
SO  - Autism Res. 2011 Aug;4(4):271-82. doi: 10.1002/aur.201. Epub 2011 May 12.


PMID- 21567305
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140613
LR  - 20161021
IS  - 0035-1776 (Print)
IS  - 0035-1776 (Linking)
VI  - 132
IP  - 2
DP  - 2011
TI  - [The civil role of experimental rationalism in the work of Federigo Enriques].
PG  - 169-89
AB  - Scientific knowledge and philosophic knowledge have an ethical responsibility
      that should not be disregarded. This observation made by scholar-philosophers
      such as Henri Poincare and Federigo Enriques has experienced an importance of
      which 20(th) century epistemology has been unaware. It is important to relaunch
      this observation in the name of older values: equality, democracy, openness,
      research without dogmatic boundaries. The analysis of the work of Enriques
      enables us to grasp the stakes of such an endeavor.
FAU - Gattinara, Enrico Castelli
AU  - Gattinara EC
AD  - Departement d'histoire, Universite de Rome 1, place Aldo Moro 5, I-00185, Roma,
      Italy, aperture@aperture-rivista.it.
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Le Role Civique du Rationalisme Experimental Chez Federigo Enriques Die Zivile
      Rolle des Experimentellen Rationalismus bei Federigo Enriques Il Ruolo Civile del
      Razionalismo Sperimentale in Federigo Enriques.
PL  - France
TA  - Rev Synth
JT  - Revue de synthese
JID - 8711586
EDAT- 2011/05/14 06:00
MHDA- 2011/05/14 06:01
CRDT- 2011/05/14 06:00
PHST- 2011/05/14 06:00 [entrez]
PHST- 2011/05/14 06:00 [pubmed]
PHST- 2011/05/14 06:01 [medline]
AID - 10.1007/s11873-011-0151-6 [doi]
PST - ppublish
SO  - Rev Synth. 2011;132(2):169-89. doi: 10.1007/s11873-011-0151-6.


PMID- 21567264
OWN - NLM
STAT- MEDLINE
DCOM- 20111110
LR  - 20220817
IS  - 1573-076X (Electronic)
IS  - 0165-005X (Linking)
VI  - 35
IP  - 2
DP  - 2011 Jun
TI  - The moral aesthetics of simulated suffering in standardized patient performances.
PG  - 134-62
LID - 10.1007/s11013-011-9211-5 [doi]
AB  - Standardized patient (SP) performances are staged clinical encounters between
      health-professional students and people who specialize in role-playing the part
      of patients. Such performances have in recent years become increasingly central
      to the teaching and assessment of clinical skills in U.S. medical schools. SP
      performances are valued for being both "real" (in that they involve interaction
      with a real person, unlike written examinations) and "not real" (in that the SP
      does not actually suffer from the condition portrayed, unlike an actual patient).
      This article considers how people involved in creating SP performances reconcile 
      a moral commitment to avoid suffering (to keep it "not real"), with an aesthetic 
      commitment to realistically portray it (to keep it "real"). The term "moral
      aesthetic" is proposed, to indicate a sensibility that combines ideas about what 
      is morally right with ideas about what is aesthetically compelling. Drawing on
      ethnographic research among SPs and SP program staff and medical faculty who work
      closely with them, this article argues that their work of creating "realism" in
      simulated clinical encounters encompasses multiple different (and sometimes
      conflicting) understandings and practices of realism, informed by three different
      moral aesthetics: (1) a moral aesthetic of induction, in which an accurate
      portrayal with a well-documented provenance serves to introduce experientially
      distant forms of suffering; (2) a moral aesthetic of inoculation, in which the
      authenticity and emotional impact of a performance are meant to inoculate
      students against the impact of future encounters with suffering; (3) a moral
      aesthetic of presence, generating forms of voice and care that are born out of
      the embodied presence of suffering individuals in a clinical space. All are
      premised on the assumption that risk and suffering can be banished from SP
      performances. This article suggests, however, that SP performances necessarily
      raise the same difficult, important, fundamentally ethical questions that are
      always involved in learning from and on human beings who are capable of
      suffering, and who need and deserve recognition and respect as well as care.
FAU - Taylor, Janelle S
AU  - Taylor JS
AD  - University of Washington, Seattle, WA, USA. jstaylor@u.washington.edu
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Cult Med Psychiatry
JT  - Culture, medicine and psychiatry
JID - 7707467
SB  - IM
MH  - Anthropology, Cultural
MH  - Curriculum
MH  - Education, Medical/*ethics
MH  - Emotions
MH  - Esthetics/*psychology
MH  - Ethics, Medical
MH  - Female
MH  - Humans
MH  - Male
MH  - *Morals
MH  - *Patient Simulation
MH  - Physician-Patient Relations
MH  - Problem-Based Learning
MH  - Reality Testing
MH  - Stress, Psychological/psychology
EDAT- 2011/05/14 06:00
MHDA- 2011/11/11 06:00
CRDT- 2011/05/14 06:00
PHST- 2011/05/14 06:00 [entrez]
PHST- 2011/05/14 06:00 [pubmed]
PHST- 2011/11/11 06:00 [medline]
AID - 10.1007/s11013-011-9211-5 [doi]
PST - ppublish
SO  - Cult Med Psychiatry. 2011 Jun;35(2):134-62. doi: 10.1007/s11013-011-9211-5.


PMID- 21567236
OWN - NLM
STAT- MEDLINE
DCOM- 20120110
LR  - 20211020
IS  - 1573-7292 (Electronic)
IS  - 1389-9600 (Linking)
VI  - 10
IP  - 3
DP  - 2011 Sep
TI  - Attitudes toward childbearing and prenatal testing in individuals undergoing
      genetic testing for Lynch syndrome.
PG  - 549-56
LID - 10.1007/s10689-011-9448-8 [doi]
AB  - To examine attitudes toward childbearing and prenatal genetic testing among
      individuals at risk for Lynch syndrome (LS), the most common type of hereditary
      colorectal cancer. Individuals undergoing clinical genetic testing for mismatch
      repair (MMR) gene mutations completed written questionnaires before and after
      testing. 161 of 192 (84%) eligible individuals participated in the study. Mean
      age was 46 years (range 20-75), 71% were female, 53% had a personal diagnosis of 
      cancer, and 68% had children. Eighty percent worried about their children's risk 
      for developing cancer; however only 9% reported their decision to have children
      was affected by their family history of cancer. When asked whether providing
      prenatal testing to carriers of MMR gene mutations was ethical, 66% (86/130) of
      respondents agreed/strongly agreed, 25% (32) were neutral and 9% (12)
      disagreed/strongly disagreed. Of 48 individuals planning to have children in the 
      future, 57% (27) intended to have children regardless of their genetic test
      result. If found to carry a MMR gene mutation that confirmed LS, 42% (20) would
      consider prenatal testing for a future pregnancy and 20% (7/35) of women would
      consider having children earlier in order to have prophylactic surgery to reduce 
      their risk for gynecologic cancers. Individuals undergoing genetic testing for LS
      may utilize test results to make reproductive decisions. Clinicians should be
      prepared to discuss options of reproductive genetic technologies during
      counseling of LS patients of childbearing age.
FAU - Dewanwala, Akriti
AU  - Dewanwala A
AD  - Division of Population Sciences, Dana-Farber Cancer Institute, Boston, MA, USA.
FAU - Chittenden, Anu
AU  - Chittenden A
FAU - Rosenblatt, Margery
AU  - Rosenblatt M
FAU - Mercado, Rowena
AU  - Mercado R
FAU - Garber, Judy E
AU  - Garber JE
FAU - Syngal, Sapna
AU  - Syngal S
FAU - Stoffel, Elena M
AU  - Stoffel EM
LA  - eng
GR  - K24 CA113433/CA/NCI NIH HHS/United States
GR  - K07 CA 120448-04/CA/NCI NIH HHS/United States
GR  - K07 CA120448/CA/NCI NIH HHS/United States
GR  - K07 CA120448-04/CA/NCI NIH HHS/United States
GR  - 3K07CA120448-03S1/CA/NCI NIH HHS/United States
GR  - K24 CA 113433/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - Netherlands
TA  - Fam Cancer
JT  - Familial cancer
JID - 100898211
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Attitude
MH  - Colorectal Neoplasms, Hereditary Nonpolyposis/*diagnosis/genetics/psychology
MH  - DNA Mismatch Repair/*genetics
MH  - Decision Making
MH  - Female
MH  - Follow-Up Studies
MH  - Genetic Markers/genetics
MH  - *Genetic Testing
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mutation/genetics
MH  - Parents/*psychology
MH  - Pregnancy
MH  - Pregnancy Complications, Neoplastic/*psychology
MH  - *Prenatal Diagnosis
MH  - Surveys and Questionnaires
MH  - Young Adult
PMC - PMC3233843
MID - NIHMS304410
EDAT- 2011/05/14 06:00
MHDA- 2012/01/11 06:00
CRDT- 2011/05/14 06:00
PHST- 2011/05/14 06:00 [entrez]
PHST- 2011/05/14 06:00 [pubmed]
PHST- 2012/01/11 06:00 [medline]
AID - 10.1007/s10689-011-9448-8 [doi]
PST - ppublish
SO  - Fam Cancer. 2011 Sep;10(3):549-56. doi: 10.1007/s10689-011-9448-8.


PMID- 21566712
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 1660-3796 (Print)
IS  - 1660-3796 (Linking)
VI  - 38
IP  - 2
DP  - 2011
TI  - Cryopreservation of Human Stem Cells for Clinical Application: A Review.
PG  - 107-123
AB  - SUMMARY: Stem cells have been used in a clinical setting for many years.
      Haematopoietic stem cells have been used for the treatment of both haematological
      and non-haematological disease; while more recently mesenchymal stem cells
      derived from bone marrow have been the subject of both laboratory and early
      clinical studies. Whilst these cells show both multipotency and expansion
      potential, they nonetheless do not form stable cell lines in culture which is
      likely to limit the breadth of their application in the field of regenerative
      medicine. Human embryonic stem cells are pluripotent cells, capable of forming
      stable cell lines which retain the capacity to differentiate into cells from all 
      three germ layers. This makes them of special significance in both regenerative
      medicine and toxicology. Induced pluripotent stem (iPS) cells may also provide a 
      similar breadth of utility without some of the confounding ethical issues
      surrounding embryonic stem cells. An essential pre-requisite to the commercial
      and clinical application of stem cells are suitable cryopreservation protocols
      for long-term storage. Whilst effective methods for cryopreservation and storage 
      have been developed for haematopoietic and mesenchymal stem cells, embryonic
      cells and iPS cells have proved more refractory. This paper reviews the current
      state of cryopreservation as it pertains to stem cells and in particular the
      embryonic and iPS cell.
FAU - Hunt, Charles J
AU  - Hunt CJ
AD  - UK Stem Cell Bank, National Institute for Biological Standards and Control,
      Health Protection Agency, South Mimms, Potters Bar, UK.
LA  - eng
PT  - Journal Article
DEP - 20110316
PL  - Switzerland
TA  - Transfus Med Hemother
JT  - Transfusion medicine and hemotherapy : offizielles Organ der Deutschen
      Gesellschaft fur Transfusionsmedizin und Immunhamatologie
JID - 101176417
PMC - PMC3088734
EDAT- 2011/05/14 06:00
MHDA- 2011/05/14 06:01
CRDT- 2011/05/14 06:00
PHST- 2011/01/17 00:00 [received]
PHST- 2011/01/26 00:00 [accepted]
PHST- 2011/05/14 06:00 [entrez]
PHST- 2011/05/14 06:00 [pubmed]
PHST- 2011/05/14 06:01 [medline]
AID - 10.1159/000326623 [doi]
AID - 000326623 [pii]
PST - ppublish
SO  - Transfus Med Hemother. 2011;38(2):107-123. doi: 10.1159/000326623. Epub 2011 Mar 
      16.


PMID- 21566025
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20220309
IS  - 1541-0048 (Electronic)
IS  - 0090-0036 (Linking)
VI  - 101
IP  - 11
DP  - 2011 Nov
TI  - Impact and ethics of excluding sweetened beverages from the SNAP program.
PG  - 2037-43
LID - 10.2105/AJPH.2011.300225 [doi]
AB  - The state of New York recently petitioned the US Department of Agriculture (USDA)
      for permission to conduct a demonstration project in which sweetened beverages
      would be excluded from the foods eligible to be purchased with Supplemental
      Assistance Nutrition Program (SNAP) benefits (i.e., food stamps) in New York
      City. The USDA and advocacy groups have raised objections to new SNAP
      restrictions such as the proposed exclusion of sweetened beverages. Some
      objections rest on empirical issues best resolved by demonstration projects or
      pilot studies of new exclusions. Other objections question the equity of
      excluding sweetened beverages from SNAP; these objections are important but not
      ethically decisive. The USDA should approve the proposed demonstration project
      and should encourage other pilot studies to assess the effects of excluding
      sweetened beverages from SNAP.
FAU - Barnhill, Anne
AU  - Barnhill A
AD  - Berman Institute of Bioethics, Baltimore, MD 21205, USA. abarnhil@jhsph.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110512
PL  - United States
TA  - Am J Public Health
JT  - American journal of public health
JID - 1254074
SB  - IM
MH  - *Beverages
MH  - Health Education
MH  - Humans
MH  - New York City
MH  - Poverty
MH  - Prejudice
MH  - Public Assistance/*ethics/*legislation & jurisprudence
MH  - United States
MH  - United States Department of Agriculture
PMC - PMC3222381
EDAT- 2011/05/14 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/05/14 06:00
PHST- 2011/05/14 06:00 [entrez]
PHST- 2011/05/14 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - AJPH.2011.300225 [pii]
AID - 10.2105/AJPH.2011.300225 [doi]
PST - ppublish
SO  - Am J Public Health. 2011 Nov;101(11):2037-43. doi: 10.2105/AJPH.2011.300225. Epub
      2011 May 12.


PMID- 21565860
OWN - NLM
STAT- MEDLINE
DCOM- 20120103
LR  - 20161125
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 10
DP  - 2011 Oct
TI  - Whatever happened to medical politics?
PG  - 631-6
LID - 10.1136/jme.2010.041277 [doi]
AB  - This paper argues the case for coming to see 'medical politics' as a topic or
      subject within medical education. First, its absence is noted from the wide array
      of paramedical subjects (medical ethics, history of medicine, the medical
      humanities, etc) currently given attention in both the medical education
      literature and in specific curricula. Second the author suggests that 'the
      political' is implicitly recognisable in the historical roots of medical ethics
      education, specifically in certain of the London Medical Group's activities, and 
      also that the medical profession, or indeed any profession, cannot be understood 
      as an apolitical form of social organisation either in its institutional or
      scientific (epistemic) forms. Some brief suggestions for introductory and
      advanced topics in medical politics are discussed and the degree to which medical
      politics ought to be taken seriously and delivered as part of medical education
      is considered. Ultimately the author concludes that medical politics might be
      considered a useful subject within medical education, but it is perhaps best
      understood as a perspective or approach that can contribute to the development of
      a more expansive perspective within the extant paramedical subjects.
FAU - Emmerich, Nathan
AU  - Emmerich N
AD  - The Institute of Governance, Queen's University Belfast, 63 University Road,
      Belfast, UK. nemmerich01@qub.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20110512
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Curriculum
MH  - Education, Medical, Undergraduate/*methods/standards
MH  - Ethics, Medical/*education
MH  - Humans
MH  - *Politics
MH  - United Kingdom
EDAT- 2011/05/14 06:00
MHDA- 2012/01/04 06:00
CRDT- 2011/05/14 06:00
PHST- 2011/05/14 06:00 [entrez]
PHST- 2011/05/14 06:00 [pubmed]
PHST- 2012/01/04 06:00 [medline]
AID - jme.2010.041277 [pii]
AID - 10.1136/jme.2010.041277 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Oct;37(10):631-6. doi: 10.1136/jme.2010.041277. Epub 2011 May 
      12.


PMID- 21565374
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20151119
IS  - 0035-3787 (Print)
IS  - 0035-3787 (Linking)
VI  - 167
IP  - 6-7
DP  - 2011 Jun-Jul
TI  - [Severe stroke: prognosis, intensive care admission and withhold and withdrawal
      treatment decisions].
PG  - 468-73
LID - 10.1016/j.neurol.2011.01.012 [doi]
AB  - INTRODUCTION: Stroke can produce irreversible brain damage of massive proportion 
      leading to severe disability and poor quality of life. Resuscitation and
      mechanical ventilation of these patients remain controversial because of the high
      mortality and severe disability involved. STATE OF ART: When prognosis is very
      poor, do-not-resuscitate orders (DNR orders) and withhold or withdrawal of
      treatment may be discussed. Studies have shown that DNR orders are relatively
      frequent in acute stroke: up to 30% of all patients, and 50% of which are given
      upon admission. DNR orders are closely associated with severity of the
      neurological deficit and age. Precise estimates of withhold and withdrawal of
      treatment are not available, but terminal extubations in severe stroke could
      contribute to 40,000 to 60,000 acute stage deaths per year. Little is known about
      the decision making process and palliative care in these situations. The
      neurological prognosis is the main explicit criterion. However, evaluation of
      neurological outcome is highly uncertain and difficult, and does not always
      reflect quality of life. Several studies have raised the issue of this disability
      paradox. Thus, physician estimation of prognosis has a profound impact on
      decisions for life sustaining therapies, and may lead to self-fulfilling
      prophecies in case of false appreciation of published evidence. Other criteria
      could influence the withhold and withdrawal of treatment decision, such as social
      conditions and patient values. PERSPECTIVES AND CONCLUSION: Decisions for
      life-sustaining therapies in severe stroke are always difficult and often based
      on subjective and uncertain criteria. We have to improve prognosis estimation and
      our understanding of patient preferences to promote patient-centered care. An
      ethical approach may guide these complex decisions.
CI  - Copyright (c) 2011 Elsevier Masson SAS. All rights reserved.
FAU - Crozier, S
AU  - Crozier S
AD  - Service Urgences Cerebrovasculaires, CHU Pitie-Salpetriere, 47-83 Boulevard de
      l'Hopital, 75651 Paris cedex 13, France. sophie.crozier@psl.aphp.fr
FAU - Santoli, F
AU  - Santoli F
FAU - Outin, H
AU  - Outin H
FAU - Aegerter, P
AU  - Aegerter P
FAU - Ducrocq, X
AU  - Ducrocq X
FAU - Bollaert, P-E
AU  - Bollaert PE
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - AVC graves : pronostic, criteres d'admission en reanimation et decisions de
      limitations et arret de traitements.
DEP - 20110511
PL  - France
TA  - Rev Neurol (Paris)
JT  - Revue neurologique
JID - 2984779R
SB  - IM
MH  - Brain Ischemia/complications
MH  - Cerebral Hemorrhage/complications
MH  - *Critical Care
MH  - Humans
MH  - Intensive Care Units
MH  - Palliative Care
MH  - *Patient Admission
MH  - Prognosis
MH  - Respiration, Artificial
MH  - Resuscitation Orders
MH  - Stroke/etiology/*therapy
MH  - *Withholding Treatment
EDAT- 2011/05/14 06:00
MHDA- 2011/10/25 06:00
CRDT- 2011/05/14 06:00
PHST- 2010/08/20 00:00 [received]
PHST- 2010/11/26 00:00 [revised]
PHST- 2011/01/17 00:00 [accepted]
PHST- 2011/05/14 06:00 [entrez]
PHST- 2011/05/14 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
AID - S0035-3787(11)00127-5 [pii]
AID - 10.1016/j.neurol.2011.01.012 [doi]
PST - ppublish
SO  - Rev Neurol (Paris). 2011 Jun-Jul;167(6-7):468-73. doi:
      10.1016/j.neurol.2011.01.012. Epub 2011 May 11.


PMID- 21564509
OWN - NLM
STAT- MEDLINE
DCOM- 20110902
LR  - 20191210
IS  - 1526-4637 (Electronic)
IS  - 1526-2375 (Linking)
VI  - 12
IP  - 5
DP  - 2011 May
TI  - The impact of the "business" of pain medicine on patient care.
PG  - 763-72
LID - 10.1111/j.1526-4637.2011.01114.x [doi]
AB  - OBJECTIVE: The objective of this article was to examine the impact on patient
      care of the growing economic forces in pain medicine. DISCUSSION: Chronic pain is
      a growing problem in the United States, as more people seek treatment than ever
      before. The practice of pain medicine is influenced by many market forces,
      including industry relationships with pain providers, lawmakers and insurance
      companies, direct-to-consumer advertising, insurance reimbursement patterns, and 
      competition among health care systems and pain management providers. These
      economic factors can encourage innovation and efficiency and may increase access 
      to pain treatment. However, they have also resulted in unrealistic expectations
      for pain relief, increased reliance on medications, widespread use of
      inadequately tested or unnecessary pain management diagnostic and treatment
      techniques, decreased use of some effective treatments, and lack of adequate pain
      education. Patients are undergoing more treatments, but there is little evidence 
      of overall improved function. CONCLUSIONS: Following guidelines set out by the
      industry and pain medicine organizations, safeguarding against false or
      incomplete advertising, establishing easier methods for questioning advertising
      content, increasing the practice of evidence-based medicine, increasing
      government-sponsored research of definitive studies, and improving communication 
      of efficacious treatment will facilitate the practice of ethical pain medicine
      and improve patient care.
CI  - Wiley Periodicals, Inc.
FAU - Taylor, Mary Lou
AU  - Taylor ML
AD  - Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 
      53188, USA. mlt@mcw.edu
LA  - eng
PT  - Journal Article
PL  - England
TA  - Pain Med
JT  - Pain medicine (Malden, Mass.)
JID - 100894201
RN  - 0 (Analgesics)
SB  - IM
CIN - Pain Med. 2011 May;12(5):761-2. PMID: 21564508
MH  - Advertising
MH  - *Analgesics/economics/therapeutic use
MH  - Chronic Disease
MH  - *Commerce/economics/ethics
MH  - Drug Industry/economics/ethics
MH  - Guidelines as Topic
MH  - Humans
MH  - Insurance, Health, Reimbursement
MH  - Pain/*drug therapy
MH  - *Patient Care/economics/ethics
EDAT- 2011/05/14 06:00
MHDA- 2011/09/03 06:00
CRDT- 2011/05/14 06:00
PHST- 2011/05/14 06:00 [entrez]
PHST- 2011/05/14 06:00 [pubmed]
PHST- 2011/09/03 06:00 [medline]
AID - 10.1111/j.1526-4637.2011.01114.x [doi]
PST - ppublish
SO  - Pain Med. 2011 May;12(5):763-72. doi: 10.1111/j.1526-4637.2011.01114.x.


PMID- 21564388
OWN - NLM
STAT- MEDLINE
DCOM- 20120201
LR  - 20220409
IS  - 1460-9592 (Electronic)
IS  - 1155-5645 (Linking)
VI  - 21
IP  - 11
DP  - 2011 Nov
TI  - A novel isotonic balanced electrolyte solution with 1% glucose for intraoperative
      fluid therapy in neonates: results of a prospective multicentre observational
      postauthorisation safety study (PASS).
PG  - 1114-8
LID - 10.1111/j.1460-9592.2011.03610.x [doi]
AB  - BACKGROUND: Neonates have a higher metabolic rate and an increased risk of
      perioperative hypoglycemia and lipolysis, but during anesthesia, both oxygen
      consumption and metabolic rate are decreased, and this may lead to reduced
      intraoperative glucose requirements. OBJECTIVE: The objective of this prospective
      multicentre observational postauthorisation safety study was to evaluate the
      intraoperative use of a novel isotonic balanced electrolyte solution with a low
      glucose concentration of 1% (BS-G1) in neonates with a particular focus on
      changes in acid-base, electrolyte, and glucose concentrations. METHODS: Following
      the local ethics committee approval, neonates with a postmenstrual age under 45
      weeks and an ASA risk score of I-IV undergoing intraoperative administration of
      BS-G1 were enrolled. Patient demographics, the performed procedure, adverse drug 
      reactions, hemodynamic data, and the results of blood gas analysis before and
      after infusion were documented with a focus on changes in acid-base, electrolyte,
      and glucose concentrations. RESULTS: In 66 neonates (ASA I-IV; postmenstrual age 
      38 +/- 4, range 25-45 weeks; body weight 2.9 +/- 0.9, range 0.65-4.6 kg), the
      mean infusion rate was 10.4 +/- 3.2 (range 4.5-19.6) ml.kg(-1) .h(-1) BS-G1.
      During the infusion, hemoglobin, hematocrit, bicarbonate, base excess, anion gap,
      strong ion difference, and calcium decreased, and chloride and glucose increased 
      significantly within the physiological range. All other measured parameters
      including sodium and lactate remained stable. Neither hypoglycemia (glucose < 3
      mm) nor hyperglycemia (glucose > 10 mm) was documented after BS-G1 infusion. No
      adverse drug reactions were reported. CONCLUSION: The study shows that the
      intraoperative use of an isotonic balanced electrolyte solution with 1% glucose
      and a mean infusion rate of 10 ml.kg(-1) .h(-1) helps to avoid acid-base
      dysbalance, hyponatraemia, hypoglycemia, ketoacidosis, and hyperglycemia in
      surgical neonates. A careful intraoperative monitoring and adaptation of the
      infusion rate as needed is crucial because the glucose and fluid requirements may
      vary widely between subjects.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Sumpelmann, Robert
AU  - Sumpelmann R
AD  - Medizinische Hochschule Hannover, Klinik fur Anasthesiologie und
      Intensivmedizin-OE 8050, Hannover, Germany. suempelmann.robert@mh-hannover.de
FAU - Mader, Thomas
AU  - Mader T
FAU - Dennhardt, Nils
AU  - Dennhardt N
FAU - Witt, Lars
AU  - Witt L
FAU - Eich, Christoph
AU  - Eich C
FAU - Osthaus, Wilhelm A
AU  - Osthaus WA
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20110513
PL  - France
TA  - Paediatr Anaesth
JT  - Paediatric anaesthesia
JID - 9206575
RN  - 0 (Blood Glucose)
RN  - 0 (Electrolytes)
RN  - 0 (Hemoglobins)
RN  - 0 (Isotonic Solutions)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Acid-Base Equilibrium/physiology
MH  - Anesthesia
MH  - Blood Glucose/metabolism
MH  - Body Weight/physiology
MH  - Electrolytes/blood
MH  - Female
MH  - Fluid Therapy/adverse effects/*methods
MH  - Gestational Age
MH  - Glucose/administration & dosage/adverse effects/*therapeutic use
MH  - Hemoglobins/metabolism
MH  - Humans
MH  - Infant, Newborn
MH  - Intraoperative Care/*methods
MH  - Isotonic Solutions/adverse effects/chemistry/*therapeutic use
MH  - Male
MH  - Monitoring, Intraoperative
MH  - Patient Safety
MH  - Prospective Studies
MH  - Sample Size
EDAT- 2011/05/14 06:00
MHDA- 2012/02/02 06:00
CRDT- 2011/05/14 06:00
PHST- 2011/05/14 06:00 [entrez]
PHST- 2011/05/14 06:00 [pubmed]
PHST- 2012/02/02 06:00 [medline]
AID - 10.1111/j.1460-9592.2011.03610.x [doi]
PST - ppublish
SO  - Paediatr Anaesth. 2011 Nov;21(11):1114-8. doi: 10.1111/j.1460-9592.2011.03610.x. 
      Epub 2011 May 13.


PMID- 21564057
OWN - NLM
STAT- MEDLINE
DCOM- 20110919
LR  - 20220409
IS  - 1545-5300 (Electronic)
IS  - 0014-7370 (Linking)
VI  - 50
IP  - 2
DP  - 2011 Jun
TI  - Community-based applied research with Latino immigrant families: informing
      practice and research according to ethical and social justice principles.
PG  - 132-48
LID - 10.1111/j.1545-5300.2011.01351.x [doi]
AB  - This manuscript describes the implementation of two community-based programs of
      research with Latino immigrant populations exposed to intense contextual
      challenges. We provide background on our program of research and specific
      implementation of an evidence-based parenting intervention. We also describe how 
      our research efforts were seriously affected by immigration-related events such
      as the ICE raids in Utah and a history of discrimination and exclusion affecting 
      Latino immigrants in Michigan. These external political and social challenges
      have affected the very core principles of our efforts to implement
      community-based approaches. The current manuscript describes key lessons that we 
      have learned in this process. Finally, reflections for research, practice, and
      social policy are included.
CI  - 2011 (c) FPI, Inc.
FAU - Baumann, Ana
AU  - Baumann A
AD  - Washington University, St. Louis, MO, USA.
FAU - Domenech Rodriguez, Melanie
AU  - Domenech Rodriguez M
FAU - Parra-Cardona, Jose Ruben
AU  - Parra-Cardona JR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Fam Process
JT  - Family process
JID - 0400666
SB  - IM
MH  - Community-Based Participatory Research/*ethics
MH  - *Emigrants and Immigrants
MH  - *Family
MH  - Family Therapy/*ethics
MH  - *Hispanic or Latino
MH  - Humans
MH  - *Principle-Based Ethics
MH  - *Social Justice
MH  - United States
EDAT- 2011/05/14 06:00
MHDA- 2011/09/20 06:00
CRDT- 2011/05/14 06:00
PHST- 2011/05/14 06:00 [entrez]
PHST- 2011/05/14 06:00 [pubmed]
PHST- 2011/09/20 06:00 [medline]
AID - 10.1111/j.1545-5300.2011.01351.x [doi]
PST - ppublish
SO  - Fam Process. 2011 Jun;50(2):132-48. doi: 10.1111/j.1545-5300.2011.01351.x.


PMID- 21564016
OWN - NLM
STAT- MEDLINE
DCOM- 20120403
LR  - 20190923
IS  - 1875-5402 (Electronic)
IS  - 1386-2073 (Linking)
VI  - 14
IP  - 8
DP  - 2011 Sep
TI  - Fireflies in the coalmine: luciferase technologies in next-generation toxicity
      testing.
PG  - 688-702
AB  - Whole-animal studies have been the mainstay of toxicity testing for decades.
      These approaches are too expensive and laborious to effectively characterize all 
      of the chemicals currently in commercial use. In addition, there are social and
      ethical pressures to reduce, refine and replace animal testing in toxicology. The
      National Research Council (NRC) has outlined a new strategy to transition from
      animal-based tests to high throughput, cell-based assays and computational
      modeling approaches to characterize chemical toxicants. Critical to this vision, 
      assays that measure toxicity pathways associated with adverse health effects must
      be developed. Bioluminescent assays are particularly well suited to the demands
      of next-generation toxicity testing because they measure a wide range of
      biological activities in a quantitative and high throughput manner. This review
      describes the limitations of traditional, animal-based toxicity testing and
      discusses the current and developing uses of bioluminescent technologies in
      next-generation testing based on three general assay formats: luciferase-limited 
      assays, ATP-limited assays and luciferin-limited assays.
FAU - Simmons, Steven O
AU  - Simmons SO
AD  - Integrated Systems Toxicology Division, National Health and Environmental Effects
      Research Laboratory, US EPA, Research Triangle Park, North Carolina, USA.
      Simmons.Steve@epa.gov
LA  - eng
PT  - Journal Article
PL  - United Arab Emirates
TA  - Comb Chem High Throughput Screen
JT  - Combinatorial chemistry & high throughput screening
JID - 9810948
RN  - EC 1.13.12.- (Luciferases)
SB  - IM
MH  - Animals
MH  - *Coal Mining
MH  - *Fireflies
MH  - Luciferases/*metabolism
MH  - *Toxicity Tests
EDAT- 2011/05/14 06:00
MHDA- 2012/04/04 06:00
CRDT- 2011/05/14 06:00
PHST- 2010/08/27 00:00 [received]
PHST- 2010/10/05 00:00 [revised]
PHST- 2011/04/26 00:00 [accepted]
PHST- 2011/05/14 06:00 [entrez]
PHST- 2011/05/14 06:00 [pubmed]
PHST- 2012/04/04 06:00 [medline]
AID - BSP/CCHTS/E- Pub/00173 [pii]
AID - 10.2174/138620711796504451 [doi]
PST - ppublish
SO  - Comb Chem High Throughput Screen. 2011 Sep;14(8):688-702. doi:
      10.2174/138620711796504451.


PMID- 21563974
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20110630
IS  - 1557-8666 (Electronic)
IS  - 1066-5277 (Linking)
VI  - 18
IP  - 7
DP  - 2011 Jul
TI  - Is there room for ethics within bioinformatics education?
PG  - 907-16
LID - 10.1089/cmb.2010.0187 [doi]
AB  - When bioinformatics education is considered, several issues are addressed. At the
      undergraduate level, the main issue revolves around conveying information from
      two main and different fields: biology and computer science. At the graduate
      level, the main issue is bridging the gap between biology students and computer
      science students. However, there is an educational component that is rarely
      addressed within the context of bioinformatics education: the ethics component.
      Here, a different perspective is provided on bioinformatics education, and the
      current status of ethics is analyzed within the existing bioinformatics programs.
      Analysis of the existing undergraduate and graduate programs, in both Europe and 
      the United States, reveals the minimal attention given to ethics within
      bioinformatics education. Given that bioinformaticians speedily and effectively
      shape the biomedical sciences and hence their implications for society, here
      redesigning of the bioinformatics curricula is suggested in order to integrate
      the necessary ethics education. Unique ethical problems awaiting
      bioinformaticians and bioinformatics ethics as a separate field of study are
      discussed. In addition, a template for an "Ethics in Bioinformatics" course is
      provided.
FAU - Taneri, Bahar
AU  - Taneri B
AD  - Department of Biological Sciences, Faculty of Arts and Sciences, Eastern
      Mediterranean University, Famagusta, North Cyprus. bahar.taneri@emu.edu.tr
LA  - eng
PT  - Journal Article
DEP - 20110512
PL  - United States
TA  - J Comput Biol
JT  - Journal of computational biology : a journal of computational molecular cell
      biology
JID - 9433358
SB  - IM
MH  - Bioethics/*education
MH  - Biology/education
MH  - Computational Biology/*education/*ethics
MH  - Curriculum/*standards
MH  - Education, Graduate
MH  - Educational Status
MH  - Europe
MH  - Humans
MH  - PubMed
MH  - Students
MH  - Teaching
MH  - United States
EDAT- 2011/05/14 06:00
MHDA- 2011/10/25 06:00
CRDT- 2011/05/14 06:00
PHST- 2011/05/14 06:00 [entrez]
PHST- 2011/05/14 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
AID - 10.1089/cmb.2010.0187 [doi]
PST - ppublish
SO  - J Comput Biol. 2011 Jul;18(7):907-16. doi: 10.1089/cmb.2010.0187. Epub 2011 May
      12.


PMID- 21563637
OWN - NLM
STAT- MEDLINE
DCOM- 20110614
LR  - 20110513
IS  - 1078-4535 (Print)
IS  - 1078-4535 (Linking)
VI  - 17
IP  - 2
DP  - 2011
TI  - Ethics at the bedside: A conversation with Hans-Peter de Ruiter, PhD, RN; Deborah
      Freeman, BSN, RN; Ronda Hughes, PhD, RN, MHS, FAAN; and Richard Sellers, MDiv,
      MA.
PG  - 96-103
FAU - de Ruiter, Hans-Peter
AU  - de Ruiter HP
FAU - Freeman, Deborah
AU  - Freeman D
FAU - Hughes, Ronda
AU  - Hughes R
FAU - Sellers, Richard
AU  - Sellers R
LA  - eng
PT  - Interview
PL  - United States
TA  - Creat Nurs
JT  - Creative nursing
JID - 9505022
MH  - *Ethics, Nursing
MH  - Evidence-Based Nursing/*ethics
MH  - Humans
MH  - Nurse-Patient Relations/*ethics
MH  - Nursing Staff, Hospital/*ethics
MH  - *Professional Autonomy
MH  - United States
EDAT- 2011/05/14 06:00
MHDA- 2011/06/15 06:00
CRDT- 2011/05/14 06:00
PHST- 2011/05/14 06:00 [entrez]
PHST- 2011/05/14 06:00 [pubmed]
PHST- 2011/06/15 06:00 [medline]
PST - ppublish
SO  - Creat Nurs. 2011;17(2):96-103.


PMID- 21563631
OWN - NLM
STAT- MEDLINE
DCOM- 20110614
LR  - 20191112
IS  - 1078-4535 (Print)
IS  - 1078-4535 (Linking)
VI  - 17
IP  - 2
DP  - 2011
TI  - The association of civility and ethics.
PG  - 61-2
FAU - Hughes, Ronda
AU  - Hughes R
LA  - eng
PT  - Editorial
PT  - Introductory Journal Article
PL  - United States
TA  - Creat Nurs
JT  - Creative nursing
JID - 9505022
MH  - *Creativity
MH  - *Ethics, Nursing
MH  - Humans
MH  - Interprofessional Relations/*ethics
MH  - *Organizational Culture
EDAT- 2011/05/14 06:00
MHDA- 2011/06/15 06:00
CRDT- 2011/05/14 06:00
PHST- 2011/05/14 06:00 [entrez]
PHST- 2011/05/14 06:00 [pubmed]
PHST- 2011/06/15 06:00 [medline]
AID - 10.1891/1078-4535.17.2.61 [doi]
PST - ppublish
SO  - Creat Nurs. 2011;17(2):61-2. doi: 10.1891/1078-4535.17.2.61.


PMID- 21563630
OWN - NLM
STAT- MEDLINE
DCOM- 20110614
LR  - 20191112
IS  - 1078-4535 (Print)
IS  - 1078-4535 (Linking)
VI  - 17
IP  - 2
DP  - 2011
TI  - Ethical practice.
PG  - 59-60
FAU - Lewis-Hunstiger, Marty
AU  - Lewis-Hunstiger M
LA  - eng
PT  - Editorial
PT  - Introductory Journal Article
PL  - United States
TA  - Creat Nurs
JT  - Creative nursing
JID - 9505022
MH  - *Creativity
MH  - *Ethics, Nursing
MH  - Humans
EDAT- 2011/05/14 06:00
MHDA- 2011/06/15 06:00
CRDT- 2011/05/14 06:00
PHST- 2011/05/14 06:00 [entrez]
PHST- 2011/05/14 06:00 [pubmed]
PHST- 2011/06/15 06:00 [medline]
AID - 10.1891/1078-4535.17.2.59 [doi]
PST - ppublish
SO  - Creat Nurs. 2011;17(2):59-60. doi: 10.1891/1078-4535.17.2.59.


PMID- 21563296
OWN - NLM
STAT- MEDLINE
DCOM- 20120105
LR  - 20131121
IS  - 1527-6473 (Electronic)
IS  - 1527-6465 (Linking)
VI  - 17
IP  - 9
DP  - 2011 Sep
TI  - Overdose with suicidal intent: ethical considerations for liver transplant
      programs.
PG  - 1111-6
LID - 10.1002/lt.22332 [doi]
AB  - Liver transplantation (LT) programs encounter patients with fulminant hepatic
      failure resulting from suicide attempts involving acetaminophen or multidrug
      ingestion. Members of transplant teams often have different opinions about
      whether these patients should be offered transplantation. Disagreements can delay
      the transfer of these patients to a transplant facility and negatively affect
      their management. Currently, transplant programs have no guidelines to help them 
      with their decisions about the appropriateness of LT for these patients. Here we 
      present a clinical case encountered at our facility, and we discuss ethical
      principles that should help programs to make informed decisions about
      transplantation for these patients.
CI  - Copyright (c) 2011 American Association for the Study of Liver Diseases.
FAU - Rhodes, Rosamond
AU  - Rhodes R
AD  - Mount Sinai School of Medicine, New York, NY, USA.
FAU - Aggarwal, Sourabh
AU  - Aggarwal S
FAU - Schiano, Thomas D
AU  - Schiano TD
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Liver Transpl
JT  - Liver transplantation : official publication of the American Association for the 
      Study of Liver Diseases and the International Liver Transplantation Society
JID - 100909185
RN  - 362O9ITL9D (Acetaminophen)
SB  - IM
MH  - Acetaminophen/*toxicity
MH  - Adult
MH  - Drug Overdose
MH  - Ethics, Medical
MH  - Female
MH  - Humans
MH  - Liver Failure, Acute/surgery/*therapy
MH  - Liver Transplantation/*ethics/*methods
MH  - Mental Disorders/complications
MH  - Patient Selection
MH  - *Suicide, Attempted
MH  - Treatment Outcome
EDAT- 2011/05/13 06:00
MHDA- 2012/01/06 06:00
CRDT- 2011/05/13 06:00
PHST- 2011/05/13 06:00 [entrez]
PHST- 2011/05/13 06:00 [pubmed]
PHST- 2012/01/06 06:00 [medline]
AID - 10.1002/lt.22332 [doi]
PST - ppublish
SO  - Liver Transpl. 2011 Sep;17(9):1111-6. doi: 10.1002/lt.22332.


PMID- 21563015
OWN - NLM
STAT- MEDLINE
DCOM- 20120130
LR  - 20110929
IS  - 1744-4144 (Electronic)
IS  - 1385-4046 (Linking)
VI  - 25
IP  - 6
DP  - 2011 Aug
TI  - The role of the independent neuropsychologist in special education.
PG  - 1058-74
LID - 10.1080/13854046.2011.565077 [doi]
AB  - Neuropsychologists are playing an increasing role in special education. We
      explain steps that neuropsychologists can take to ethically and effectively
      approach the "quasi-forensic" role of independent evaluator. Because
      neuropsychologists may provide reports for treatment, school programming, and
      legal disputes, it is important that they are familiar with the school
      programming process and the unique litigation procedures available for children
      with disabilities in special education. We provide guidelines including
      determining referral questions, obtaining outside information, choosing
      assessments, considering the legal constructs of questions, reviewing discrepant 
      results from other evaluations and Individual Education Plans and communicating
      ideas.
FAU - Hurewitz, Felicia
AU  - Hurewitz F
AD  - Psychology Department, Drexel University, 3141 Chestnut Street, Philadelphia, PA 
      19104-2875, USA. fdh23@drexel.edu
FAU - Kerr, Sonja
AU  - Kerr S
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110624
PL  - England
TA  - Clin Neuropsychol
JT  - The Clinical neuropsychologist
JID - 8806548
SB  - IM
MH  - *Attitude to Health
MH  - Child
MH  - Communication
MH  - Disabled Children/*education
MH  - *Education, Special
MH  - Humans
MH  - Referral and Consultation
EDAT- 2011/05/13 06:00
MHDA- 2012/01/31 06:00
CRDT- 2011/05/13 06:00
PHST- 2011/05/13 06:00 [entrez]
PHST- 2011/05/13 06:00 [pubmed]
PHST- 2012/01/31 06:00 [medline]
AID - 937456896 [pii]
AID - 10.1080/13854046.2011.565077 [doi]
PST - ppublish
SO  - Clin Neuropsychol. 2011 Aug;25(6):1058-74. doi: 10.1080/13854046.2011.565077.
      Epub 2011 Jun 24.


PMID- 21562003
OWN - NLM
STAT- MEDLINE
DCOM- 20110718
LR  - 20211020
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 342
DP  - 2011 May 11
TI  - Inadequate reporting of research ethics review and informed consent in cluster
      randomised trials: review of random sample of published trials.
PG  - d2496
LID - 10.1136/bmj.d2496 [doi]
LID - bmj.d2496 [pii]
AB  - OBJECTIVES: To investigate the extent to which authors of cluster randomised
      trials adhered to two basic requirements of the World Medical Association's
      Declaration of Helsinki and the International Committee of Medical Journal
      Editors' uniform requirements for manuscripts (namely, reporting of research
      ethics review and informed consent), to determine whether the adequacy of
      reporting has improved over time, and to identify characteristics of cluster
      randomised trials associated with reporting of ethics practices. DESIGN: Review
      of a random sample of published cluster randomised trials from an electronic
      search in Medline. SETTING: Cluster randomised trials in health research
      published in English language journals from 2000 to 2008. Study sample 300
      cluster randomised trials published in 150 journals. RESULTS: 77 (26%, 95%
      confidence interval 21% to 31%) trials failed to report ethics review. The
      proportion reporting ethics review increased significantly over time (P<0.001).
      Trials with data collection interventions at the individual level were more
      likely to report ethics review than were trials that used routine data sources
      only (79% (n=151) v 55% (23); P=0.008). Trials that accounted for clustering in
      the design and analysis were more likely to report ethics review. The median
      impact factor of the journal of publication was higher for trials that reported
      ethics review (3.4 v 2.3; P<0.001). 93 (31%, 26% to 36%) trials failed to report 
      consent. Reporting of consent increased significantly over time (P<0.001). Trials
      with interventions targeting participants at the individual level were more
      likely to report consent than were trials with interventions targeting the
      cluster level (87% (90) v 48% (41); P<0.001). Trials with data collection
      interventions at the individual level were more likely to report consent than
      were those that used routine data sources only (78% (146) v 29% (11); P<0.001).
      CONCLUSIONS: Reporting of research ethics protections in cluster randomised
      trials is inadequate. In addition to research ethics approval, authors should
      report whether informed consent was sought, from whom consent was sought, and
      what consent was for.
FAU - Taljaard, Monica
AU  - Taljaard M
AD  - Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa
      Hospital, Civic Campus, 1053 Carling Avenue, Ottawa, ON, Canada K1Y 4E9.
      mtaljaard@ohri.ca
FAU - McRae, Andrew D
AU  - McRae AD
FAU - Weijer, Charles
AU  - Weijer C
FAU - Bennett, Carol
AU  - Bennett C
FAU - Dixon, Stephanie
AU  - Dixon S
FAU - Taleban, Julia
AU  - Taleban J
FAU - Skea, Zoe
AU  - Skea Z
FAU - Eccles, Martin P
AU  - Eccles MP
FAU - Brehaut, Jamie C
AU  - Brehaut JC
FAU - Donner, Allan
AU  - Donner A
FAU - Saginur, Raphael
AU  - Saginur R
FAU - Boruch, Robert F
AU  - Boruch RF
FAU - Grimshaw, Jeremy M
AU  - Grimshaw JM
LA  - eng
GR  - HSRU2/CSO_/Chief Scientist Office/United Kingdom
GR  - MOP85066/CAPMC/ CIHR/Canada
GR  - MOP89790/CAPMC/ CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110511
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
SB  - IM
MH  - Cluster Analysis
MH  - *Ethics, Research
MH  - Informed Consent/*ethics
MH  - Journal Impact Factor
MH  - Randomized Controlled Trials as Topic/*ethics
MH  - Research Design
PMC - PMC3092521
EDAT- 2011/05/13 06:00
MHDA- 2011/07/19 06:00
CRDT- 2011/05/13 06:00
PHST- 2011/05/13 06:00 [entrez]
PHST- 2011/05/13 06:00 [pubmed]
PHST- 2011/07/19 06:00 [medline]
AID - 10.1136/bmj.d2496 [doi]
PST - epublish
SO  - BMJ. 2011 May 11;342:d2496. doi: 10.1136/bmj.d2496.


PMID- 21561522
OWN - NLM
STAT- MEDLINE
DCOM- 20110922
LR  - 20181201
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 39
IP  - 2
DP  - 2011 Summer
TI  - Reining in the pharmacological enhancement train: we should remain vigilant about
      regulatory standards for prescribing controlled substances.
PG  - 272-9
LID - 10.1111/j.1748-720X.2011.00596.x [doi]
AB  - This article challenges recent assumptions that physicians may ethically and
      legally prescribe psychopharmacological enhancement drugs to patients and the
      counterintuitive notion that in some cases ingesting an enhancement drug
      constitutes the more ethical choice than foregoing this option. Enhancement
      proponents have touted modafinil as an ideal mechanism to improve concentration, 
      alertness, and forego sleep and keep pace with our society's demands. However,
      patients who use modafinil for these reasons risk potentially severe side effects
      and addiction, and face unintended consequences related to their cognitive,
      emotive, and physiological functioning. Importantly, prescribing a controlled
      substance such as modafinil for performance enhancement and sleep avoidance runs 
      contrary to a physician's ethical duty to the patient and the standard of
      practice set forth in legal requirements governing the prescription of controlled
      substances.
CI  - (c) 2011 American Society of Law, Medicine & Ethics, Inc.
FAU - Drabiak-Syed, Katherine
AU  - Drabiak-Syed K
AD  - Indiana University Center for Bioethics, IN, USA.
LA  - eng
GR  - RR025761/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Central Nervous System Stimulants)
RN  - R3UK8X3U3D (Modafinil)
MH  - Benzhydryl Compounds/adverse effects/*therapeutic use
MH  - Central Nervous System Stimulants/adverse effects/*therapeutic use
MH  - Cognition/*drug effects
MH  - Drug Approval
MH  - Drug Utilization
MH  - *Drug and Narcotic Control
MH  - Fatigue/*drug therapy
MH  - Humans
MH  - Modafinil
MH  - United States
MH  - United States Food and Drug Administration
MH  - Work Schedule Tolerance
EDAT- 2011/05/13 06:00
MHDA- 2011/09/23 06:00
CRDT- 2011/05/13 06:00
PHST- 2011/05/13 06:00 [entrez]
PHST- 2011/05/13 06:00 [pubmed]
PHST- 2011/09/23 06:00 [medline]
AID - 10.1111/j.1748-720X.2011.00596.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2011 Summer;39(2):272-9. doi: 10.1111/j.1748-720X.2011.00596.x.


PMID- 21561521
OWN - NLM
STAT- MEDLINE
DCOM- 20110922
LR  - 20191210
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 39
IP  - 2
DP  - 2011 Summer
TI  - Testing public health ethics: why the CDC's HIV screening recommendations may
      violate the least infringement principle.
PG  - 263-71
LID - 10.1111/j.1748-720X.2011.00595.x [doi]
AB  - The CDC's HIV screening recommendations for health care settings advocate
      abandoning two important autonomy protections: (1) pretest counseling and (2) the
      requirement that providers obtain affirmative agreement from patients prior to
      testing. The recommendations may violate the least infringement principle because
      there is insufficient evidence to conclude that abandoning pretest counseling or 
      affirmative agreement requirements will further the CDC's stated public health
      goals.
CI  - (c) 2011 American Society of Law, Medicine & Ethics, Inc.
FAU - Pierce, Matthew W
AU  - Pierce MW
AD  - Injury Prevention Research Center, University of North Carolina at Chapel Hill,
      NC, USA.
FAU - Maman, Suzanne
AU  - Maman S
FAU - Groves, Allison K
AU  - Groves AK
FAU - King, Elizabeth J
AU  - King EJ
FAU - Wyckoff, Sarah C
AU  - Wyckoff SC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - AIDS Serodiagnosis/economics/*ethics/psychology
MH  - *Centers for Disease Control and Prevention, U.S.
MH  - Counseling
MH  - Female
MH  - Humans
MH  - Informed Consent
MH  - Patient Acceptance of Health Care
MH  - *Patient Rights
MH  - Personal Autonomy
MH  - Pregnancy
MH  - United States
EDAT- 2011/05/13 06:00
MHDA- 2011/09/23 06:00
CRDT- 2011/05/13 06:00
PHST- 2011/05/13 06:00 [entrez]
PHST- 2011/05/13 06:00 [pubmed]
PHST- 2011/09/23 06:00 [medline]
AID - 10.1111/j.1748-720X.2011.00595.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2011 Summer;39(2):263-71. doi:
      10.1111/j.1748-720X.2011.00595.x.


PMID- 21561520
OWN - NLM
STAT- MEDLINE
DCOM- 20110922
LR  - 20181201
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 39
IP  - 2
DP  - 2011 Summer
TI  - Multi-professional recommendations for access and utilization of critical care
      services: towards consistency in practice and ethical decision-making processes.
PG  - 254-62
LID - 10.1111/j.1748-720X.2011.00594.x [doi]
AB  - Multiprofessional guidelines for fair access to and use of adult critical care
      services are desperately needed to define a consistent transparent standard of
      care: when such therapies have the potential to benefit and help a patient as
      they journey with illness and when they cannot.
CI  - (c) 2011 American Society of Law, Medicine & Ethics, Inc.
FAU - Hawryluck, Laura
AU  - Hawryluck L
AD  - University Health Network, University of Ottawa Hospital, Ottawa, Ontario,
      Canada.
FAU - Bouali, Redouane
AU  - Bouali R
FAU - Meth, Nathalie Danjoux
AU  - Meth ND
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Adult
MH  - *Bioethical Issues
MH  - Critical Care/ethics/*statistics & numerical data
MH  - *Health Services Accessibility/ethics
MH  - Humans
MH  - Life Support Care/ethics/statistics & numerical data
MH  - Medical Futility
MH  - Practice Guidelines as Topic
MH  - Quality of Health Care
MH  - United States
EDAT- 2011/05/13 06:00
MHDA- 2011/09/23 06:00
CRDT- 2011/05/13 06:00
PHST- 2011/05/13 06:00 [entrez]
PHST- 2011/05/13 06:00 [pubmed]
PHST- 2011/09/23 06:00 [medline]
AID - 10.1111/j.1748-720X.2011.00594.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2011 Summer;39(2):254-62. doi:
      10.1111/j.1748-720X.2011.00594.x.


PMID- 21561519
OWN - NLM
STAT- MEDLINE
DCOM- 20110922
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 39
IP  - 2
DP  - 2011 Summer
TI  - A living wage for research subjects.
PG  - 243-53
LID - 10.1111/j.1748-720X.2011.00593.x [doi]
AB  - Offering cash payments to research subjects is a common recruiting method, but
      this practice continues to be controversial because of its potential to
      compromise the protection of human subjects. Federal regulations and guidelines
      currently allow researchers to pay subjects for participation, but they say very 
      little about how much researchers can pay their subjects. This paper argues that 
      the federal regulations and guidelines should implement a standard payment
      formula. It argues for a wage payment model, and critically examines three
      candidates for a base wage: the nonfarm production wage, the FLSA minimum wage,
      and a living wage. After showing that the nonfarm production wage is too high to 
      satisfy ethical criteria, and the minimum wage is too low, this paper concludes
      that the wage payment model with a base wage equivalent to a living wage is the
      best candidate for a standard payment formula in human subjects research.
CI  - (c) 2011 American Society of Law, Medicine & Ethics, Inc.
FAU - Phillips, Trisha B
AU  - Phillips TB
AD  - Mississippi State University, MS, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - *Bioethical Issues
MH  - *Ethics, Research
MH  - Humans
MH  - Motivation
MH  - Research Subjects/*economics/psychology
MH  - *Salaries and Fringe Benefits
EDAT- 2011/05/13 06:00
MHDA- 2011/09/23 06:00
CRDT- 2011/05/13 06:00
PHST- 2011/05/13 06:00 [entrez]
PHST- 2011/05/13 06:00 [pubmed]
PHST- 2011/09/23 06:00 [medline]
AID - 10.1111/j.1748-720X.2011.00593.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2011 Summer;39(2):243-53. doi:
      10.1111/j.1748-720X.2011.00593.x.


PMID- 21561518
OWN - NLM
STAT- MEDLINE
DCOM- 20110922
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 39
IP  - 2
DP  - 2011 Summer
TI  - Fetal pain, abortion, viability, and the Constitution.
PG  - 235-42
LID - 10.1111/j.1748-720X.2011.00592.x [doi]
AB  - In early 2010, the Nebraska state legislature passed a new abortion restricting
      law asserting a new, compelling state interest in preventing fetal pain. In this 
      article, we review existing constitutional abortion doctrine and note
      difficulties presented by persistent legal attention to a socially derived
      viability construct. We then offer a substantive biological, ethical, and legal
      critique of the new fetal pain rationale.
CI  - (c) 2011 American Society of Law, Medicine & Ethics, Inc.
FAU - Cohen, I Glenn
AU  - Cohen IG
AD  - Petrie-Flom Center for Health Law Policy, Biotechnology, and Bioethics, Harvard
      Law School, MA, USA.
FAU - Sayeed, Sadath
AU  - Sayeed S
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Abortion, Induced/*legislation & jurisprudence
MH  - Female
MH  - *Fetal Viability
MH  - Fetus/*physiology
MH  - Humans
MH  - Nebraska
MH  - *Pain
MH  - Pregnancy
MH  - Supreme Court Decisions
MH  - United States
EDAT- 2011/05/13 06:00
MHDA- 2011/09/23 06:00
CRDT- 2011/05/13 06:00
PHST- 2011/05/13 06:00 [entrez]
PHST- 2011/05/13 06:00 [pubmed]
PHST- 2011/09/23 06:00 [medline]
AID - 10.1111/j.1748-720X.2011.00592.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2011 Summer;39(2):235-42. doi:
      10.1111/j.1748-720X.2011.00592.x.


PMID- 21561517
OWN - NLM
STAT- MEDLINE
DCOM- 20110922
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 39
IP  - 2
DP  - 2011 Summer
TI  - In the business of dying: questioning the commercialization of hospice.
PG  - 224-34
LID - 10.1111/j.1748-720X.2011.00591.x [doi]
AB  - This article critically questions the commercialization of hospice care and the
      ethical concerns associated with the industry's movement toward "market-driven
      medicine" at the end of life. For example, the article examines issues raised by 
      an influx of for-profit hospice providers whose business model appears at its
      core to have an ethical conflict of interest between shareholders doing well and 
      terminal patients dying well. Yet, empirical data analyzing the experience of
      patients across the hospice industry are limited, and general claims that
      end-of-life patient care is inferior among for-profit providers or even that
      their business practices are somehow unseemly when compared to nonprofit
      providers cannot be substantiated. In fact, non-profit providers are not immune
      to potentially conflicting concerns regarding financial viability (i.e., "no
      margin, no mission"). Given the limitations of existing empirical data and
      contrasting ideological commitments of for-profit versus non-profit providers,
      the questions raised by this article highlight important areas for reflection and
      further study. Policymakers and regulators are cautioned to keep ethical concerns
      in the fore as an increasingly commercialized hospice industry continues to
      emerge as a dominant component of the U.S. health care system. Both practitioners
      and researchers are encouraged to expand their efforts to better understand how
      business practices and commercial interests may compromise the death process of
      the patient and patient's family--a process premised upon a philosophy and
      ethical tradition that earlier generations of hospice providers and proponents
      established as a trusted, end-of-life alternative.
CI  - (c) 2011 American Society of Law, Medicine & Ethics, Inc.
FAU - Perry, Joshua E
AU  - Perry JE
AD  - Department of Business Law and Ethics, Kelley School of Business, Indiana
      University, IN, USA.
FAU - Stone, Robert C
AU  - Stone RC
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Health Expenditures
MH  - Health Facilities, Proprietary/*economics
MH  - Hospice Care/*economics
MH  - Humans
MH  - Medicare
MH  - Organizations, Nonprofit
MH  - *Terminal Care
MH  - United States
EDAT- 2011/05/13 06:00
MHDA- 2011/09/23 06:00
CRDT- 2011/05/13 06:00
PHST- 2011/05/13 06:00 [entrez]
PHST- 2011/05/13 06:00 [pubmed]
PHST- 2011/09/23 06:00 [medline]
AID - 10.1111/j.1748-720X.2011.00591.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2011 Summer;39(2):224-34. doi:
      10.1111/j.1748-720X.2011.00591.x.


PMID- 21561512
OWN - NLM
STAT- MEDLINE
DCOM- 20110922
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 39
IP  - 2
DP  - 2011 Summer
TI  - Futility, autonomy, and cost in end-of-life care.
PG  - 172-82
LID - 10.1111/j.1748-720X.2011.00586.x [doi]
AB  - This paper uses the controversy over the denial of care on futility grounds as a 
      window into the broader issue of the role of cost in decisions about treatment
      near the end of life. The focus is on a topic that has not received the attention
      it deserves: the difference between refusing medical treatment and demanding it. 
      The author discusses health care reform and the ethics of cost control, arguing
      that we cannot achieve universal access to quality care at affordable care
      without better public understanding of the moral legitimacy of taking cost into
      account in health care decisions, even decisions at the end of life.
CI  - (c) 2011 American Society of Law, Medicine & Ethics, Inc.
FAU - Baily, Mary Ann
AU  - Baily MA
AD  - The Hastings Center.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Family/psychology
MH  - *Health Care Costs
MH  - *Health Care Rationing
MH  - Humans
MH  - *Medical Futility/ethics
MH  - *Personal Autonomy
MH  - Professional Autonomy
MH  - Terminal Care/*economics/*ethics
MH  - Treatment Refusal
MH  - United States
EDAT- 2011/05/13 06:00
MHDA- 2011/09/23 06:00
CRDT- 2011/05/13 06:00
PHST- 2011/05/13 06:00 [entrez]
PHST- 2011/05/13 06:00 [pubmed]
PHST- 2011/09/23 06:00 [medline]
AID - 10.1111/j.1748-720X.2011.00586.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2011 Summer;39(2):172-82. doi:
      10.1111/j.1748-720X.2011.00586.x.


PMID- 21561509
OWN - NLM
STAT- MEDLINE
DCOM- 20110922
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 39
IP  - 2
DP  - 2011 Summer
TI  - Care, compassion, or cost: redefining the basis of treatment in ethics and law.
PG  - 130-9
LID - 10.1111/j.1748-720X.2011.00583.x [doi]
AB  - There are in two assumptions inherent in this issue's theme, both inimical to the
      traditional goals of medicine and to the standards of care it proposed. First,
      the idea that treatment must be limited for some (but not others) on the basis of
      cost was born in the early literature of bioethics. Second, that there is a
      quantifiable and diagnostically predictable period at the "end-of-life" where
      treatment is "futile," and therefore not worth supporting in a context of
      scarcity grew out of bioethics's construction of allocative protocols in the
      1990s. This paper traces the history of these ideas as constructs grounded in
      neither natural scarcity nor in firm diagnostic categories. Their relation to
      issues of care is therefore suspect.
CI  - (c) 2011 American Society of Law, Medicine & Ethics, Inc.
FAU - Koch, Tom
AU  - Koch T
AD  - Alton Medical Centre, Toronto, Ontario, Canada.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - *Bioethics
MH  - Chronic Disease/therapy
MH  - Critical Illness/therapy
MH  - Empathy/*ethics
MH  - Health Care Rationing
MH  - History, 20th Century
MH  - Humans
MH  - Terminal Care/*ethics/history
MH  - United States
MH  - Withholding Treatment/*ethics/history
EDAT- 2011/05/13 06:00
MHDA- 2011/09/23 06:00
CRDT- 2011/05/13 06:00
PHST- 2011/05/13 06:00 [entrez]
PHST- 2011/05/13 06:00 [pubmed]
PHST- 2011/09/23 06:00 [medline]
AID - 10.1111/j.1748-720X.2011.00583.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2011 Summer;39(2):130-9. doi: 10.1111/j.1748-720X.2011.00583.x.


PMID- 21561508
OWN - NLM
STAT- MEDLINE
DCOM- 20110922
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 39
IP  - 2
DP  - 2011 Summer
TI  - The ethical implications of health spending: death and other expensive
      conditions.
PG  - 121-9
LID - 10.1111/j.1748-720X.2011.00582.x [doi]
AB  - The cost of health care in the United States has important generational
      considerations whether analyzed at a point in time, or over many years. The
      budgets of governments contain important information about the funding of public 
      services, including health care, and the intra- and inter-generational
      implications of both the inherent tradeoffs, and the particular means of funding 
      the services. End-of-life expenditures, while a significant component of the cost
      of health care, are not the primary consideration in the ethical or moral
      questions raised.
CI  - (c) 2011 American Society of Law, Medicine & Ethics, Inc.
FAU - Crippen, Dan
AU  - Crippen D
AD  - National Governors Association.
FAU - Barnato, Amber E
AU  - Barnato AE
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Aged
MH  - Budgets
MH  - Child
MH  - Child Health Services/economics
MH  - Child Welfare/economics
MH  - Chronic Disease/economics
MH  - *Economics
MH  - *Health Expenditures
MH  - Health Services for the Aged/economics
MH  - Humans
MH  - Insurance, Health/economics
MH  - Medicaid/economics
MH  - Medicare/economics
MH  - Terminal Care/*economics
MH  - United States
EDAT- 2011/05/13 06:00
MHDA- 2011/09/23 06:00
CRDT- 2011/05/13 06:00
PHST- 2011/05/13 06:00 [entrez]
PHST- 2011/05/13 06:00 [pubmed]
PHST- 2011/09/23 06:00 [medline]
AID - 10.1111/j.1748-720X.2011.00582.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2011 Summer;39(2):121-9. doi: 10.1111/j.1748-720X.2011.00582.x.


PMID- 21561460
OWN - NLM
STAT- MEDLINE
DCOM- 20120227
LR  - 20111104
IS  - 1467-9566 (Electronic)
IS  - 0141-9889 (Linking)
VI  - 33
IP  - 7
DP  - 2011 Nov
TI  - Long-term effects of poor health on employment: the significance of life stage
      and educational level.
PG  - 1096-111
LID - 10.1111/j.1467-9566.2011.01346.x [doi]
AB  - Previous research has found the employment consequences of poor health to be of
      increased magnitude in low qualified groups. The purpose of this study is to
      investigate if this relationship varies within different stages of the life
      course when focusing on long term associations with non-employment. An
      expectation of the article is that stronger effects of poor health may be found
      in young adults compared to middle aged people. The article considers two
      possible explanations: normative change and life stage resources. Using
      three-wave panel data from the Norwegian county of Nord-Trondelag, the HUNT study
      allows the study of respondents over two decades. Two narrow cohorts have been
      selected for comparison, and health was measured by self-reported longstanding
      limiting illness. For the analyses, cross tabulations, logistic regression, and
      fixed effects logistic regression techniques are used. The article concludes in
      favour of the resource explanation; young adulthood is a critical period in
      relation to long term employment consequences of poor health, and especially so
      among people with fewer educational resources. Cohort differences in the
      employment consequences of poor health are not likely to be caused by poorer work
      ethics among younger cohorts.
CI  - (c) 2011 The Author. Sociology of Health & Illness (c) 2011 Foundation for the
      Sociology of Health & Illness/Blackwell Publishing Ltd.
FAU - van der Wel, Kjetil A
AU  - van der Wel KA
AD  - Faculty of Social Sciences, Oslo University College, Norway.
      kjetil.wel@sam.hio.no
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110511
PL  - England
TA  - Sociol Health Illn
JT  - Sociology of health & illness
JID - 8205036
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aging
MH  - Chronic Disease
MH  - Confidence Intervals
MH  - Educational Status
MH  - Employment/*psychology
MH  - Female
MH  - Health Status
MH  - *Health Status Disparities
MH  - Humans
MH  - Logistic Models
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Norway
MH  - Prejudice
MH  - Social Perception
MH  - *Time
MH  - Time Factors
MH  - Young Adult
EDAT- 2011/05/13 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/05/13 06:00
PHST- 2011/05/13 06:00 [entrez]
PHST- 2011/05/13 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - 10.1111/j.1467-9566.2011.01346.x [doi]
PST - ppublish
SO  - Sociol Health Illn. 2011 Nov;33(7):1096-111. doi:
      10.1111/j.1467-9566.2011.01346.x. Epub 2011 May 11.


PMID- 21561348
OWN - NLM
STAT- MEDLINE
DCOM- 20110601
LR  - 20220321
IS  - 1533-4406 (Electronic)
IS  - 0028-4793 (Linking)
VI  - 364
IP  - 19
DP  - 2011 May 12
TI  - Anterior colporrhaphy versus transvaginal mesh for pelvic-organ prolapse.
PG  - 1826-36
LID - 10.1056/NEJMoa1009521 [doi]
AB  - BACKGROUND: The use of standardized mesh kits for repair of pelvic-organ prolapse
      has spread rapidly in recent years, but it is unclear whether this approach
      results in better outcomes than traditional colporrhaphy. METHODS: In this
      multicenter, parallel-group, randomized, controlled trial, we compared the use of
      a trocar-guided, transvaginal polypropylene-mesh repair kit with traditional
      colporrhaphy in women with prolapse of the anterior vaginal wall (cystocele). The
      primary outcome was a composite of the objective anatomical designation of stage 
      0 (no prolapse) or 1 (position of the anterior vaginal wall more than 1 cm above 
      the hymen), according to the Pelvic Organ Prolapse Quantification system, and the
      subjective absence of symptoms of vaginal bulging 12 months after the surgery.
      RESULTS: Of 389 women who were randomly assigned to a study treatment, 200
      underwent prolapse repair with the transvaginal mesh kit and 189 underwent
      traditional colporrhaphy. At 1 year, the primary outcome was significantly more
      common in the women treated with transvaginal mesh repair (60.8%) than in those
      who underwent colporrhaphy (34.5%) (absolute difference, 26.3 percentage points; 
      95% confidence interval, 15.6 to 37.0). The surgery lasted longer and the rates
      of intraoperative hemorrhage were higher in the mesh-repair group than in the
      colporrhaphy group (P<0.001 for both comparisons). Rates of bladder perforation
      were 3.5% in the mesh-repair group and 0.5% in the colporrhaphy group (P=0.07),
      and the respective rates of new stress urinary incontinence after surgery were
      12.3% and 6.3% (P=0.05). Surgical reintervention to correct mesh exposure during 
      follow-up occurred in 3.2% of 186 patients in the mesh-repair group. CONCLUSIONS:
      As compared with anterior colporrhaphy, use of a standardized, trocar-guided mesh
      kit for cystocele repair resulted in higher short-term rates of successful
      treatment but also in higher rates of surgical complications and postoperative
      adverse events. (Funded by the Karolinska Institutet and Ethicon;
      ClinicalTrials.gov number, NCT00566917.).
FAU - Altman, Daniel
AU  - Altman D
AD  - Division of Obstetrics and Gynecology, Department of Clinical Science, Danderyd
      Hospital, Stockholm, Sweden. daniel.altman@ds.se
FAU - Vayrynen, Tapio
AU  - Vayrynen T
FAU - Engh, Marie Ellstrom
AU  - Engh ME
FAU - Axelsen, Susanne
AU  - Axelsen S
FAU - Falconer, Christian
AU  - Falconer C
CN  - Nordic Transvaginal Mesh Group
LA  - eng
SI  - ClinicalTrials.gov/NCT00566917
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - N Engl J Med
JT  - The New England journal of medicine
JID - 0255562
SB  - IM
EIN - N Engl J Med. 2013 Jan 24;368(4):394
MH  - Aged
MH  - Female
MH  - Gynecologic Surgical Procedures/*methods
MH  - Humans
MH  - Logistic Models
MH  - Middle Aged
MH  - Pelvic Organ Prolapse/*surgery
MH  - Postoperative Complications
MH  - *Surgical Mesh
MH  - Treatment Outcome
MH  - Urinary Bladder/injuries
MH  - Vagina/*surgery
IR  - Altman D
FIR - Altman, Daniel
IR  - Asplund Isaksson C
FIR - Asplund Isaksson, Catarina
IR  - Craford K
FIR - Craford, Kristina
IR  - Ek M
FIR - Ek, Marion
IR  - Elmer C
FIR - Elmer, Caroline
IR  - Enesund L
FIR - Enesund, Lena
IR  - Falconer C
FIR - Falconer, Christian
IR  - Flam F
FIR - Flam, Folke
IR  - Franzen K
FIR - Franzen, Karin
IR  - Gottlieb P
FIR - Gottlieb, Philip
IR  - Gunnarsson J
FIR - Gunnarsson, Jonas
IR  - Gustafson T
FIR - Gustafson, Tanja
IR  - Holm B
FIR - Holm, Bjorn
IR  - Hogeras I
FIR - Hogeras, Ingela
IR  - Json-Soderstrom A
FIR - Json-Soderstrom, Annelie
IR  - Kjaeldgaard A
FIR - Kjaeldgaard, Anders
IR  - Klemets U
FIR - Klemets, Ulrika
IR  - Krohn K
FIR - Krohn, Kenneth
IR  - Kroon UB
FIR - Kroon, Ulla-Beth
IR  - Kyrklund N
FIR - Kyrklund, Nina
IR  - Larsson G
FIR - Larsson, Gregor
IR  - Larsson PG
FIR - Larsson, P-G
IR  - Linqvist Berglund M
FIR - Linqvist Berglund, Margareta
IR  - Lowenadler P
FIR - Lowenadler, Paula
IR  - Murkes D
FIR - Murkes, Daniel
IR  - Rezapour M
FIR - Rezapour, Masoumeh
IR  - Sorensen J
FIR - Sorensen, Jesper
IR  - Taheri-Johansson F
FIR - Taheri-Johansson, Fatima
IR  - Tegerstedt G
FIR - Tegerstedt, Gunilla
IR  - Tsaknakis V
FIR - Tsaknakis, Vasiliki
IR  - Uustal Fornell E
FIR - Uustal Fornell, Eva
IR  - Vejt E
FIR - Vejt, Eva
IR  - Winberg T
FIR - Winberg, Tomas
IR  - Aaltonen R
FIR - Aaltonen, Riikka
IR  - Aukee P
FIR - Aukee, Pauliina
IR  - Kiilholma P
FIR - Kiilholma, Pentti
IR  - Kulju P
FIR - Kulju, Pekka
IR  - Mikkola T
FIR - Mikkola, Tomi
IR  - Molander P
FIR - Molander, Pontus
IR  - Raty R
FIR - Raty, Raija
IR  - Vallasto A
FIR - Vallasto, Arimo
IR  - Valpas A
FIR - Valpas, Antti
IR  - Vayrynen T
FIR - Vayrynen, Tapio
IR  - Axelsen S
FIR - Axelsen, Susanne
IR  - Bek KM
FIR - Bek, Karl Moller
IR  - Rudnicki M
FIR - Rudnicki, Martin
IR  - Engh ME
FIR - Engh, Marie Elstrom
IR  - Kasin K
FIR - Kasin, Kolbjorn
IR  - Kinne I
FIR - Kinne, Ingeborg
IR  - Kirschner R
FIR - Kirschner, Rolf
IR  - Kral G
FIR - Kral, Gabriel
IR  - Kulseng Hansen S
FIR - Kulseng Hansen, Sigurd
IR  - Milenkovic M
FIR - Milenkovic, Milan
IR  - Muehlan A
FIR - Muehlan, Axel
IR  - Petrovic V
FIR - Petrovic, Vladimir
IR  - Rosic B
FIR - Rosic, Branislav
IR  - Rygh A
FIR - Rygh, Astrid
IR  - Solberg P
FIR - Solberg, Per
IR  - Tjugum J
FIR - Tjugum, Jostein
EDAT- 2011/05/13 06:00
MHDA- 2011/06/02 06:00
CRDT- 2011/05/13 06:00
PHST- 2011/05/13 06:00 [entrez]
PHST- 2011/05/13 06:00 [pubmed]
PHST- 2011/06/02 06:00 [medline]
AID - 10.1056/NEJMoa1009521 [doi]
PST - ppublish
SO  - N Engl J Med. 2011 May 12;364(19):1826-36. doi: 10.1056/NEJMoa1009521.


PMID- 21560962
OWN - NLM
STAT- MEDLINE
DCOM- 20110701
LR  - 20110926
IS  - 1092-0811 (Print)
IS  - 1092-0811 (Linking)
VI  - 20
IP  - 2
DP  - 2011 Mar-Apr
TI  - Left ventricular assist device deactivation: ethical issues.
PG  - 98-100
FAU - Lachman, Vicki D
AU  - Lachman VD
AD  - Drexel University, Philadelphia, PA, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medsurg Nurs
JT  - Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses
JID - 9300545
CIN - Medsurg Nurs. 2011 Jul-Aug;20(4):207. PMID: 21941935
MH  - Ethics, Nursing
MH  - Heart Failure/nursing/*therapy
MH  - Heart-Assist Devices/*ethics
MH  - Humans
MH  - Medical Futility/*ethics
MH  - Nurse's Role
EDAT- 2011/05/13 06:00
MHDA- 2011/07/02 06:00
CRDT- 2011/05/13 06:00
PHST- 2011/05/13 06:00 [entrez]
PHST- 2011/05/13 06:00 [pubmed]
PHST- 2011/07/02 06:00 [medline]
PST - ppublish
SO  - Medsurg Nurs. 2011 Mar-Apr;20(2):98-100.


PMID- 21560951
OWN - NLM
STAT- MEDLINE
DCOM- 20110606
LR  - 20110512
IS  - 1461-3123 (Print)
IS  - 1461-3123 (Linking)
VI  - 14
IP  - 4
DP  - 2011 Apr
TI  - Using historical research to make sense of our past, our present and our future. 
      3. Finding and using historical sources.
PG  - 37-8
AB  - This article is the third of a series of four pieces looking at the use of
      historical research to explore midwifery. It considers the practicalities of
      finding and using historical sources, and at some of the ethical implications
      involved. Midwifery sources can be hard to track down as they range from
      catalogued collections to papers stored in shoe boxes under peoples' beds. Oral
      history can be a powerful way of capturing stories and memories that were never
      written down. Care needs to taken in using sources sensitively, particularly when
      they involve people who are still alive.
FAU - McIntosh, Tania
AU  - McIntosh T
AD  - University of Nottingham.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - England
TA  - Pract Midwife
JT  - The practising midwife
JID - 9814758
MH  - Education, Nursing, Baccalaureate/*organization & administration/trends
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - *History of Nursing
MH  - History, 20th Century
MH  - Humans
MH  - Midwifery/*education/*trends
MH  - Nurse Midwives/education
MH  - *Nurse's Role
MH  - *Nursing Records
MH  - Professional Autonomy
MH  - Students, Nursing
MH  - Women's Health
EDAT- 2011/05/13 06:00
MHDA- 2011/06/07 06:00
CRDT- 2011/05/13 06:00
PHST- 2011/05/13 06:00 [entrez]
PHST- 2011/05/13 06:00 [pubmed]
PHST- 2011/06/07 06:00 [medline]
PST - ppublish
SO  - Pract Midwife. 2011 Apr;14(4):37-8.


PMID- 21560552
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20180221
IS  - 1750-4589 (Print)
IS  - 1750-4589 (Linking)
VI  - 21
IP  - 4
DP  - 2011 Apr
TI  - A simple guide to gaining ethical approval for perioperative nursing research.
PG  - 123-7
AB  - Research ethics relate to three groups of perioperative nurses: those who
      undertake research within the clinical area, those clinically responsible for
      patients taking part in research studies or trials, and finally the students and 
      qualified staff who critique research articles and want to ensure that the
      standard of ethical rigour is acceptable. This article contains guidelines based 
      on essential research ethical principles for each of these three groups and
      outlines the application process for gaining ethical approval.
FAU - Rees, Colin
AU  - Rees C
AD  - School of Nursing and Midwifery Studies, Cardiff University, Ty Dewi Sant,
      Cardiff, CF14 4XN. reescb@cardiff.ac.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Perioper Pract
JT  - Journal of perioperative practice
JID - 101271023
MH  - *Ethics, Nursing
MH  - *Nursing Research
MH  - *Perioperative Nursing
EDAT- 2011/05/13 06:00
MHDA- 2011/06/03 06:00
CRDT- 2011/05/13 06:00
PHST- 2011/05/13 06:00 [entrez]
PHST- 2011/05/13 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
AID - 10.1177/175045891102100402 [doi]
PST - ppublish
SO  - J Perioper Pract. 2011 Apr;21(4):123-7. doi: 10.1177/175045891102100402.


PMID- 21560408
OWN - NLM
STAT- MEDLINE
DCOM- 20110804
LR  - 20110510
IS  - 0047-1860 (Print)
IS  - 0047-1860 (Linking)
VI  - 59
IP  - 3
DP  - 2011 Mar
TI  - [Ethical problems in utilization of specimens after laboratory examinations for
      clinical studies].
PG  - 264-72
AB  - Ethical Committee in Japanese Society of Laboratory Medicine published "Opinions 
      of Japanese Society of Laboratory Medicine about utilization of specimens after
      laboratory examinations for laboratory work, education and clinical studies" in
      2002. Ministry of Health, Labour and Welfare in Japan established "Ethical
      Guidelines for Clinical Studies" in 2003, and amended the document in 2008.
      According to the guidelines, Ethical Committee in Japanese Society of Laboratory 
      Medicine revised the "Opinions of Japanese Society of Laboratory Medicine about
      utilization of specimens after laboratory examinations for laboratory work,
      education and clinical studies" in 2010. Ethical problems in utilization of
      specimens after laboratory examinations for clinical studies are discussed.
FAU - Murakami, Masami
AU  - Murakami M
AD  - Department of Clinical Laboratory Medicine, Gunma University Graduate School of
      Medicine, Maebashi 371-8511, Japan. mmurakam@showa.gunma-u.ac.jp
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Rinsho Byori
JT  - Rinsho byori. The Japanese journal of clinical pathology
JID - 2984781R
SB  - IM
MH  - Humans
MH  - Japan
MH  - Pathology, Clinical/*ethics
MH  - Practice Guidelines as Topic
MH  - Societies, Medical
MH  - Specimen Handling/*ethics
EDAT- 2011/05/13 06:00
MHDA- 2011/08/05 06:00
CRDT- 2011/05/13 06:00
PHST- 2011/05/13 06:00 [entrez]
PHST- 2011/05/13 06:00 [pubmed]
PHST- 2011/08/05 06:00 [medline]
PST - ppublish
SO  - Rinsho Byori. 2011 Mar;59(3):264-72.


PMID- 21560031
OWN - NLM
STAT- MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1573-076X (Electronic)
IS  - 0165-005X (Linking)
VI  - 35
IP  - 2
DP  - 2011 Jun
TI  - Learning the moral economy of commodified health care: "community education,"
      failed consumers, and the shaping of ethical clinician-citizens.
PG  - 183-208
LID - 10.1007/s11013-011-9208-0 [doi]
AB  - Leaders of health professional schools often support community-based education as
      a means of promoting emerging practitioners' awareness of health disparities and 
      commitment to serving the poor. Yet, most programs do not teach about the causes 
      of health disparities, raising questions regarding what social and political
      lessons students learn from these experiences. This article examines the ways in 
      which community-based clinical education programs help shape the subjectivities
      of new dentists as ethical clinician-citizens within the US commodified health
      care system. Drawing on ethnographic research during volunteer and required
      community-based programs and interviews with participants, I demonstrate three
      implicit logics that students learned: (1) dialectical ideologies of volunteer
      entitlement and recipient debt; (2) forms of justification for the often inferior
      care provided to "failed" consumers (patients with Medicaid or uninsured); and
      (3) specific forms of obligations characterizing the ethical clinician-citizen. I
      explore the ways these messages reflected the structured relations of both
      student encounters and the overarching health care system, and examine the
      strategies faculty supervisors undertook to challenge these messages and
      relations. Finally, I argue that promoting commitments to social justice in
      health care should not rely on cultivating altruism, but should instead be
      pursued through educating new practitioners about the lives of poor people, the
      causal relationships between poverty and poor health, and attention to the
      structure of health care and provider-patient interactions. This approach
      involves shining a critical light on America's commodified health care system as 
      an arena based in relations of power and inequality.
FAU - Rivkin-Fish, Michele
AU  - Rivkin-Fish M
AD  - Department of Anthropology, University of North Carolina, Chapel Hill, 301 Alumni
      Bldg CB #3115, Chapel Hill, NC 27599-3115, USA. mrfish@unc.edu
LA  - eng
GR  - R24 HD050924/HD/NICHD NIH HHS/United States
PT  - Journal Article
PL  - Netherlands
TA  - Cult Med Psychiatry
JT  - Culture, medicine and psychiatry
JID - 7707467
SB  - IM
MH  - Anthropology, Cultural/*education/ethics
MH  - *Commodification
MH  - Community Dentistry/*education/*ethics
MH  - Curriculum
MH  - Delivery of Health Care/ethics
MH  - Dentist-Patient Relations
MH  - *Education, Dental
MH  - Empathy
MH  - Ethics, Dental
MH  - Healthcare Disparities/*ethics
MH  - Humans
MH  - Medical Indigency
MH  - *Morals
MH  - Social Responsibility
MH  - United States
MH  - Volunteers/education
EDAT- 2011/05/12 06:00
MHDA- 2011/11/11 06:00
CRDT- 2011/05/12 06:00
PHST- 2011/05/12 06:00 [entrez]
PHST- 2011/05/12 06:00 [pubmed]
PHST- 2011/11/11 06:00 [medline]
AID - 10.1007/s11013-011-9208-0 [doi]
PST - ppublish
SO  - Cult Med Psychiatry. 2011 Jun;35(2):183-208. doi: 10.1007/s11013-011-9208-0.


PMID- 21559921
OWN - NLM
STAT- MEDLINE
DCOM- 20120723
LR  - 20211020
IS  - 1573-2789 (Electronic)
IS  - 0010-3853 (Linking)
VI  - 48
IP  - 2
DP  - 2012 Apr
TI  - Military mental health professionals on operational deployment: an exploratory
      study.
PG  - 238-48
LID - 10.1007/s10597-011-9407-8 [doi]
AB  - This exploratory study aimed to develop greater insight into the occupational and
      personal nature of the practice of mental healthcare on operational deployments. 
      Twenty-eight British military mental health professionals were identified as
      having recently returned from deployment, with 35% agreeing to participate in
      semi-structured qualitative interviews. Results suggest that whilst this
      population have a range of stressors, their main concern is to work towards the
      success of the overall mission objectives, mainly through achieving their
      clinical goals. Such work is impacted by challenges such as ethical difficulties,
      professional obstacles, bonding with colleagues and personal issues. They do
      however rely upon a range of intra and inter-personal strategies to overcome
      these hurdles successfully. A number of suggestions for improved mental
      healthcare on deployment are also identified. A review of the implications of the
      findings is offered and recommendations for improved training and support for
      mental healthcare professionals are explored. Finally, potential avenues for
      future research are considered.
FAU - McCauley, Mathew
AU  - McCauley M
AD  - Behavioral Health Flight, 48 MDOS/SGOW, United States Air Force, RAF Lakenheath, 
      Lakenheath, UK. mathew.mccauley@lakenheath.af.mil
FAU - Liebling-Kalifani, Helen
AU  - Liebling-Kalifani H
FAU - Hughes, Jamie Hacker
AU  - Hughes JH
LA  - eng
PT  - Journal Article
DEP - 20110511
PL  - United States
TA  - Community Ment Health J
JT  - Community mental health journal
JID - 0005735
SB  - IM
MH  - Adult
MH  - England
MH  - Humans
MH  - Interviews as Topic
MH  - Iraq War, 2003-2011
MH  - *Mental Health Services
MH  - *Military Personnel
MH  - *Nurses
MH  - *Psychiatry
MH  - Reproducibility of Results
EDAT- 2011/05/12 06:00
MHDA- 2012/07/24 06:00
CRDT- 2011/05/12 06:00
PHST- 2010/02/09 00:00 [received]
PHST- 2011/04/25 00:00 [accepted]
PHST- 2011/05/12 06:00 [entrez]
PHST- 2011/05/12 06:00 [pubmed]
PHST- 2012/07/24 06:00 [medline]
AID - 10.1007/s10597-011-9407-8 [doi]
PST - ppublish
SO  - Community Ment Health J. 2012 Apr;48(2):238-48. doi: 10.1007/s10597-011-9407-8.
      Epub 2011 May 11.


PMID- 21559784
OWN - NLM
STAT- MEDLINE
DCOM- 20110909
LR  - 20110523
IS  - 1572-8358 (Electronic)
IS  - 0001-5342 (Linking)
VI  - 59
IP  - 2
DP  - 2011 Jun
TI  - The concept of animal welfare at the interface between producers and scientists: 
      the example of organic pig farming.
PG  - 173-83
LID - 10.1007/s10441-011-9135-z [doi]
AB  - In organic farming animal welfare is one important aspect included in the
      internationally agreed organic principles of health, ecology, fairness and care
      (IFOAM 2006), reflecting expectation of consumers and farmers. The definition of 
      organic animal welfare includes-besides traditional terms of animal
      welfare-'regeneration' and 'naturalness'. Organic animal welfare assessment needs
      to reflect this and use complex parameters, include natural behaviour and a
      systemic view. Furthermore, various parties with seemingly conflicting interests 
      are involved, causing ethical dilemmas, such as the use of nose rings for outdoor
      sows (impaired animal welfare vs. destruction of humus). Solutions can only be
      found when foundational concepts are translated and applied to practical
      situations. On-farm animal welfare assessment and implementation of improvement
      strategies are increasingly relevant scientific areas. They combine on-farm
      welfare assessment, identification of key problem areas and connected risk
      factors. Constant communication between all parties is crucial for success.
      Animal health and welfare planning is one application of this approach, which was
      carried out on Austrian organic pig farms as well as organic dairy farms in seven
      European countries. The projects included welfare assessment, feedback and
      benchmarking as a tool for communication between farmers, advisors and
      scientists. Finally goals were set by the farmer and improvement strategies
      applicable to organic farming were implemented. This included prevention of
      disease by management strategies instead of routine treatment with pharmaceutical
      products. It appeared that next to problem structuring, multidisciplinary problem
      solving demands good communications skills to relate animal welfare science to
      value reflections.
FAU - Leeb, Christine
AU  - Leeb C
AD  - University of Natural Resources and Life Sciences, Vienna, Austria.
      christine.leeb@boku.ac.at
LA  - eng
PT  - Journal Article
DEP - 20110511
PL  - Netherlands
TA  - Acta Biotheor
JT  - Acta biotheoretica
JID - 0421520
SB  - IM
MH  - Agriculture/methods
MH  - Animal Experimentation/*ethics
MH  - Animal Husbandry/*ethics/methods
MH  - Animal Rights
MH  - Animal Welfare/*ethics
MH  - Animals
MH  - *Animals, Domestic
MH  - Ethical Theory
MH  - Ethics
MH  - Europe
MH  - Organic Agriculture
MH  - Swine
EDAT- 2011/05/12 06:00
MHDA- 2011/09/10 06:00
CRDT- 2011/05/12 06:00
PHST- 2011/04/21 00:00 [received]
PHST- 2011/04/25 00:00 [accepted]
PHST- 2011/05/12 06:00 [entrez]
PHST- 2011/05/12 06:00 [pubmed]
PHST- 2011/09/10 06:00 [medline]
AID - 10.1007/s10441-011-9135-z [doi]
PST - ppublish
SO  - Acta Biotheor. 2011 Jun;59(2):173-83. doi: 10.1007/s10441-011-9135-z. Epub 2011
      May 11.


PMID- 21559322
OWN - NLM
STAT- MEDLINE
DCOM- 20110907
LR  - 20220317
IS  - 1545-7885 (Electronic)
IS  - 1544-9173 (Linking)
VI  - 9
IP  - 5
DP  - 2011 May
TI  - Limbic justice--amygdala involvement in immediate rejection in the Ultimatum
      Game.
PG  - e1001054
LID - 10.1371/journal.pbio.1001054 [doi]
AB  - Imaging studies have revealed a putative neural account of emotional bias in
      decision making. However, it has been difficult in previous studies to identify
      the causal role of the different sub-regions involved in decision making. The
      Ultimatum Game (UG) is a game to study the punishment of norm-violating behavior.
      In a previous influential paper on UG it was suggested that frontal insular
      cortex has a pivotal role in the rejection response. This view has not been
      reconciled with a vast literature that attributes a crucial role in emotional
      decision making to a subcortical structure (i.e., amygdala). In this study we
      propose an anatomy-informed model that may join these views. We also present a
      design that detects the functional anatomical response to unfair proposals in a
      subcortical network that mediates rapid reactive responses. We used a functional 
      MRI paradigm to study the early components of decision making and challenged our 
      paradigm with the introduction of a pharmacological intervention to perturb the
      elicited behavioral and neural response. Benzodiazepine treatment decreased the
      rejection rate (from 37.6% to 19.0%) concomitantly with a diminished amygdala
      response to unfair proposals, and this in spite of an unchanged feeling of
      unfairness and unchanged insular response. In the control group, rejection was
      directly linked to an increase in amygdala activity. These results allow a
      functional anatomical detection of the early neural components of rejection
      associated with the initial reactive emotional response. Thus, the act of
      immediate rejection seems to be mediated by the limbic system and is not solely
      driven by cortical processes, as previously suggested. Our results also prompt an
      ethical discussion as we demonstrated that a commonly used drug influences core
      functions in the human brain that underlie individual autonomy and economic
      decision making.
FAU - Gospic, Katarina
AU  - Gospic K
AD  - MR Research Center and Osher Center for Integrative Medicine, Department of
      Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
      katarina.gospic@ki.se
FAU - Mohlin, Erik
AU  - Mohlin E
FAU - Fransson, Peter
AU  - Fransson P
FAU - Petrovic, Predrag
AU  - Petrovic P
FAU - Johannesson, Magnus
AU  - Johannesson M
FAU - Ingvar, Martin
AU  - Ingvar M
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110503
PL  - United States
TA  - PLoS Biol
JT  - PLoS biology
JID - 101183755
RN  - 6GOW6DWN2A (Oxazepam)
SB  - IM
MH  - Adult
MH  - Amygdala/anatomy & histology/drug effects/*physiology
MH  - *Decision Making/drug effects
MH  - Female
MH  - *Games, Experimental
MH  - Humans
MH  - Limbic System/anatomy & histology/drug effects/*physiology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Neuropsychological Tests
MH  - Oxazepam/pharmacology
MH  - *Rejection, Psychology
MH  - Statistics, Nonparametric
MH  - Young Adult
PMC - PMC3086869
COIS- The authors have declared that no competing interests exist.
EDAT- 2011/05/12 06:00
MHDA- 2011/09/08 06:00
CRDT- 2011/05/12 06:00
PHST- 2011/01/26 00:00 [received]
PHST- 2011/03/21 00:00 [accepted]
PHST- 2011/05/12 06:00 [entrez]
PHST- 2011/05/12 06:00 [pubmed]
PHST- 2011/09/08 06:00 [medline]
AID - 10.1371/journal.pbio.1001054 [doi]
AID - PBIOLOGY-D-11-00371 [pii]
PST - ppublish
SO  - PLoS Biol. 2011 May;9(5):e1001054. doi: 10.1371/journal.pbio.1001054. Epub 2011
      May 3.


PMID- 21559317
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1937-5719 (Electronic)
IS  - 1937-5719 (Linking)
VI  - 11
DP  - 2011 Apr 29
TI  - Identity transfer and identity restoration in facial allotransplantation.
PG  - e20
AB  - OBJECTIVE: Facial allotransplantation is fast becoming a reconstructive option
      for severely disfigured individuals, but it is still in experimental stage.
      Facial allotransplantation will be considered fully ethical only when it
      addresses the recipient's identity concerns. There exist no such studies that
      quantify and predict identity changes following change in geometry of underlying 
      facial skeleton and overlying soft tissue morphology. I objectively address these
      identity concerns in the present study. METHODS: Using software (Mimics version
      14.0, Materialise, Plymouth, Michigan), I developed 3-dimensional facial models
      from the computed tomographic images of 4 identical and 1 nonidentical twin
      pairs. On the basis of cranial base anatomy, 3-dimensional coordinate values of
      selected landmark locations were measured (Surgicase, Materialise, Plymouth,
      Michigan) and a morphometric method was applied to quantify identity differences 
      between them. Identity parameters were drawn on a diagrammatic chart that
      depicted the biophysical identity range. Using software (Mimics version 14.0),
      facial allotransplant simulation was done involving most of the nasal bone,
      maxilla, and zygoma. Morphological parameters of resulting new identity were
      drawn on diagrammatic chart and if they fell within the chart, facial
      allotransplantation resulted in identity transfer. Moreover, a scale was used to 
      quantify identity transfer and identity restoration resulting from facial
      allotransplantation. RESULTS: Identity changes of facial allotransplantation are 
      objectively quantified that can be used as a communication tool in consent taking
      process. CONCLUSION: My findings suggest that donor facial allograft may be
      identified on the recipient's face depending upon underlying craniofacial
      morphology and accordingly, identity changes can be suitably predicted.
FAU - Modgil, Ajay
AU  - Modgil A
AD  - Home Clinic, Vikas Nagar, Una 174303, Himachal Pradesh, India.
LA  - eng
PT  - Journal Article
DEP - 20110429
PL  - United States
TA  - Eplasty
JT  - Eplasty
JID - 101316107
PMC - PMC3086515
EDAT- 2011/05/12 06:00
MHDA- 2011/05/12 06:01
CRDT- 2011/05/12 06:00
PHST- 2011/05/12 06:00 [entrez]
PHST- 2011/05/12 06:00 [pubmed]
PHST- 2011/05/12 06:01 [medline]
PST - epublish
SO  - Eplasty. 2011 Apr 29;11:e20.


PMID- 21559309
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1662-5145 (Electronic)
IS  - 1662-5145 (Linking)
VI  - 5
DP  - 2011
TI  - Informed consent in deep brain stimulation - ethical considerations in a stress
      field of pride and prejudice.
PG  - 7
LID - 10.3389/fnint.2011.00007 [doi]
FAU - Skuban, Tobias
AU  - Skuban T
AD  - Department of Psychiatry and Psychotherapy, University of Cologne Cologne,
      Germany.
FAU - Hardenacke, Katja
AU  - Hardenacke K
FAU - Woopen, Christiane
AU  - Woopen C
FAU - Kuhn, Jens
AU  - Kuhn J
LA  - eng
PT  - Journal Article
DEP - 20110429
PL  - Switzerland
TA  - Front Integr Neurosci
JT  - Frontiers in integrative neuroscience
JID - 101477950
PMC - PMC3085861
EDAT- 2011/05/12 06:00
MHDA- 2011/05/12 06:01
CRDT- 2011/05/12 06:00
PHST- 2010/12/31 00:00 [received]
PHST- 2011/04/18 00:00 [accepted]
PHST- 2011/05/12 06:00 [entrez]
PHST- 2011/05/12 06:00 [pubmed]
PHST- 2011/05/12 06:01 [medline]
AID - 10.3389/fnint.2011.00007 [doi]
PST - epublish
SO  - Front Integr Neurosci. 2011 Apr 29;5:7. doi: 10.3389/fnint.2011.00007.
      eCollection 2011.


PMID- 21558635
OWN - NLM
STAT- MEDLINE
DCOM- 20110830
LR  - 20110511
IS  - 1878-6448 (Electronic)
IS  - 1053-8135 (Linking)
VI  - 28
IP  - 3
DP  - 2011
TI  - Policies concerning assistive technology and home modification services for
      people with physical and cognitive disabilities in Sweden.
PG  - 303-8
LID - 10.3233/NRE-2011-0658 [doi]
AB  - The purpose of this paper is to describe policies, laws and regulations regarding
      the procurement of assistive technology and home modifications for individuals
      with disabilities in Sweden. Children up to ages 17-21 are entitled to free
      access to assistive technology. For adults the access is substantially subsidized
      with public funding. We will discuss the issues and implications of new
      technology, with an emphasis on assistive technology for cognitive impairment.
      Today, the social security system is financially burdened due to increasing
      demands and limited economic growth. However, the basic doctrine of the "Swedish 
      model" remains, evoking structural and ethical issues.
FAU - Bartfai, Aniko
AU  - Bartfai A
AD  - Karolinska Institutet, Department of Clinical Sciences Danderyds Hospital,
      Division of Rehabilitation Medicine, Stockholm, Sweden.
FAU - Boman, Inga-Lill
AU  - Boman IL
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - NeuroRehabilitation
JT  - NeuroRehabilitation
JID - 9113791
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cognition Disorders/rehabilitation
MH  - Disabled Persons/*rehabilitation
MH  - *Facility Design and Construction
MH  - *Housing
MH  - Humans
MH  - *Policy
MH  - Prescriptions
MH  - *Self-Help Devices/trends
MH  - Sweden
MH  - Young Adult
EDAT- 2011/05/12 06:00
MHDA- 2011/08/31 06:00
CRDT- 2011/05/12 06:00
PHST- 2011/05/12 06:00 [entrez]
PHST- 2011/05/12 06:00 [pubmed]
PHST- 2011/08/31 06:00 [medline]
AID - NL78V67U51613732 [pii]
AID - 10.3233/NRE-2011-0658 [doi]
PST - ppublish
SO  - NeuroRehabilitation. 2011;28(3):303-8. doi: 10.3233/NRE-2011-0658.


PMID- 21558633
OWN - NLM
STAT- MEDLINE
DCOM- 20110830
LR  - 20181201
IS  - 1878-6448 (Electronic)
IS  - 1053-8135 (Linking)
VI  - 28
IP  - 3
DP  - 2011
TI  - Creating an assistive technology clinic: the experience of the Johns Hopkins AT
      clinic for patients with ALS.
PG  - 281-93
LID - 10.3233/NRE-2011-0656 [doi]
AB  - For persons with Amyotrophic Lateral Sclerosis (ALS), comprehensive
      multidisciplinary care can effectively improve overall quality of life from
      diagnosis to end of life [16]. Considering the rapidly progressive loss in
      overall function experienced by persons with ALS, it is essential to provide
      comprehensive multidisciplinary care, including Assistive Technology (AT)
      services, in an effective and efficient manner. AT is an important adjunctive
      therapy for people with neurological disability. For people with complex
      conditions, access to a comprehensive AT clinic can be the best way to access
      these tools. Unfortunately, few medical centers have invested in AT clinics, and 
      managers may not understand how to go about developing AT resources at their
      facility. This article chronicles the step-by-step development of The Johns
      Hopkins Assistive Technology Clinic for persons with ALS. It offers background
      evidence, the process of program development, and insight into the experience of 
      professional accountability of one occupational therapist turned AT Director. It 
      also details descriptions of the stakeholders and their roles in the development 
      process, funding and ethical considerations, and barriers to implementation. It
      is hoped that this may provide guidance for teams who may wish to build AT
      facilities in their own practice settings.
FAU - Casey, Kelly Showalter
AU  - Casey KS
AD  - Johns Hopkins Hospital, Johns Hopkins ALS Clinic, 600 North Wolfe Street, Meyer
      2-109, Baltimore, MD 21287, USA. kshowal1@jhmi.edu
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - NeuroRehabilitation
JT  - NeuroRehabilitation
JID - 9113791
SB  - IM
MH  - *Ambulatory Care Facilities/organization & administration
MH  - Amyotrophic Lateral Sclerosis/physiopathology/psychology/*rehabilitation
MH  - Bioethics
MH  - Financial Support
MH  - Humans
MH  - Interdisciplinary Communication
MH  - Occupational Therapy
MH  - Personnel Staffing and Scheduling
MH  - Program Development/economics
MH  - Quality of Life
MH  - *Self-Help Devices/ethics
MH  - Speech-Language Pathology/methods
MH  - Treatment Outcome
MH  - Workforce
EDAT- 2011/05/12 06:00
MHDA- 2011/08/31 06:00
CRDT- 2011/05/12 06:00
PHST- 2011/05/12 06:00 [entrez]
PHST- 2011/05/12 06:00 [pubmed]
PHST- 2011/08/31 06:00 [medline]
AID - M5268R31H6U82T17 [pii]
AID - 10.3233/NRE-2011-0656 [doi]
PST - ppublish
SO  - NeuroRehabilitation. 2011;28(3):281-93. doi: 10.3233/NRE-2011-0656.


PMID- 21558581
OWN - NLM
STAT- MEDLINE
DCOM- 20110621
LR  - 20191210
IS  - 0895-2779 (Print)
IS  - 0895-2779 (Linking)
VI  - 33
IP  - 2
DP  - 2011 Apr
TI  - Masculinity, moral atmosphere, and moral functioning of high school football
      players.
PG  - 215-34
AB  - In order to identify factors associated with on-field moral functioning among
      student athletes within the unique context of football, we examined masculine
      gender role conflict, moral atmosphere, and athletic identity. Using structural
      equation modeling to assess survey data from 204 high school football players,
      results demonstrated that moral atmosphere (i.e., the influence of coaches and
      teammates) was significantly associated with participants' process of on-field
      moral functioning across the levels of judgment, intention, and behavior. Neither
      masculine gender role conflict nor athletic identity significantly predicted
      moral functioning, but the results indicated that participants' identification
      with the athlete role significantly predicted conflict with socialized gender
      roles. Results suggest that in the aggressive and violent sport of football,
      coaches can have a direct influence on players' moral functioning process.
      Coaches can also have an indirect effect by influencing all the players so that a
      culture of ethical play can be cultivated among teammates and spread from the top
      down.
FAU - Steinfeldt, Jesse A
AU  - Steinfeldt JA
AD  - Department of Counseling and Educational Psychology, Indiana University,
      Bloomington, IN, USA.
FAU - Rutkowski, Leslie A
AU  - Rutkowski LA
FAU - Vaughan, Ellen L
AU  - Vaughan EL
FAU - Steinfeldt, Matthew C
AU  - Steinfeldt MC
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Sport Exerc Psychol
JT  - Journal of sport & exercise psychology
JID - 8809258
SB  - IM
MH  - Adolescent
MH  - Conflict, Psychological
MH  - Football/*psychology
MH  - Humans
MH  - Intention
MH  - Judgment
MH  - Male
MH  - *Masculinity
MH  - *Morals
MH  - Personality Inventory/statistics & numerical data
MH  - Psychometrics
MH  - Social Desirability
MH  - Social Identification
MH  - Socialization
EDAT- 2011/05/12 06:00
MHDA- 2011/06/22 06:00
CRDT- 2011/05/12 06:00
PHST- 2011/05/12 06:00 [entrez]
PHST- 2011/05/12 06:00 [pubmed]
PHST- 2011/06/22 06:00 [medline]
AID - 10.1123/jsep.33.2.215 [doi]
PST - ppublish
SO  - J Sport Exerc Psychol. 2011 Apr;33(2):215-34. doi: 10.1123/jsep.33.2.215.


PMID- 21558311
OWN - NLM
STAT- MEDLINE
DCOM- 20110902
LR  - 20211020
IS  - 1945-7170 (Electronic)
IS  - 0013-7227 (Linking)
VI  - 152
IP  - 7
DP  - 2011 Jul
TI  - The expression and regulation of adrenomedullin in the human endometrium: a
      candidate for endometrial repair.
PG  - 2845-56
LID - 10.1210/en.2010-1256 [doi]
AB  - After menstruation, the endometrium has a remarkable capacity for repair, but the
      factors involved remain undefined. We hypothesize adrenomedullin (AM) plays a
      role in this process. Premenstrually progesterone levels decline, stimulating
      prostaglandin (PG) synthesis, vasoconstriction, and hypoxia. This study aimed to 
      determine 1) AM expression throughout the menstrual (M) cycle and 2) its
      regulation by PG and hypoxia. Human endometrial biopsies (n = 51) were collected 
      with ethical approval and consent. AM mRNA expression was examined by
      quantitative RT-PCR and was found to be selectively elevated in endometrium from 
      the menstrual (M) phase (P < 0.001). AM immunohistochemical staining was maximal 
      in M and proliferative (P) endometrium. Culture of secretory, but not P, explants
      with 100 nm PGF(2alpha) or hypoxia (0.5% O2) increased AM mRNA (P < 0.05). P
      explants were induced to increase AM expression using in vitro progesterone
      withdrawal but required the presence of hypoxia (P < 0.05). Short hairpin
      sequences against hypoxia-inducible factor-1alpha (HIF-1alpha) inhibited AM
      hypoxic up-regulation but did not alter PGF(2alpha)-induced expression. The AM
      receptor was immunolocalized to endothelial cells in both lymphatic and blood
      vessels. Conditioned medium from PGF(2alpha)-treated cells increased endothelial 
      cell proliferation and branching (P < 0.05). This was abolished by AM receptor
      antagonists. In conclusion, AM is elevated at the time of endometrial repair and 
      induces both angiogenesis and lymphangiogenesis by stimulating endothelial cell
      proliferation and tube formation. In the human endometrium, AM expression is
      up-regulated by two mechanisms: a HIF-1alpha-mediated hypoxic induction and a
      HIF-1alpha-independent PGF(2alpha) pathway. These physiological mechanisms may
      provide novel therapeutic targets for disorders such as heavy menstrual bleeding.
FAU - Maybin, Jacqueline A
AU  - Maybin JA
AD  - Centre for Reproductive Biology, The Queen's Medical Research Institute,
      University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom.
FAU - Battersby, Sharon
AU  - Battersby S
FAU - Hirani, Nikhil
AU  - Hirani N
FAU - Nikitenko, Leonid L
AU  - Nikitenko LL
FAU - Critchley, Hilary O D
AU  - Critchley HO
FAU - Jabbour, Henry N
AU  - Jabbour HN
LA  - eng
GR  - G0600048/MRC_/Medical Research Council/United Kingdom
GR  - G0600048(80179)/MRC_/Medical Research Council/United Kingdom
GR  - G1002033/MRC_/Medical Research Council/United Kingdom
GR  - WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110510
PL  - United States
TA  - Endocrinology
JT  - Endocrinology
JID - 0375040
RN  - 0 (ADM protein, human)
RN  - 0 (Angiogenesis Inducing Agents)
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - 0 (RNA, Messenger)
RN  - 0 (RNA, Small Interfering)
RN  - 0 (Receptors, Adrenomedullin)
RN  - 0 (Receptors, Prostaglandin)
RN  - 148498-78-6 (Adrenomedullin)
RN  - B7IN85G1HY (Dinoprost)
SB  - IM
MH  - Adrenomedullin/genetics/*metabolism
MH  - Adult
MH  - Angiogenesis Inducing Agents/metabolism
MH  - Cell Hypoxia
MH  - Cell Line
MH  - Cell Proliferation
MH  - Dinoprost/metabolism
MH  - Endometrium/blood supply/cytology/*physiology
MH  - Endothelium, Vascular/physiology
MH  - Female
MH  - *Gene Expression Regulation
MH  - Gene Silencing
MH  - Humans
MH  - Hypoxia-Inducible Factor 1/antagonists & inhibitors/genetics
MH  - Lymphangiogenesis
MH  - Menstrual Cycle/*metabolism
MH  - Middle Aged
MH  - Organ Culture Techniques
MH  - RNA, Messenger/metabolism
MH  - RNA, Small Interfering
MH  - Receptors, Adrenomedullin/antagonists & inhibitors/metabolism
MH  - Receptors, Prostaglandin/metabolism
PMC - PMC3192419
EDAT- 2011/05/12 06:00
MHDA- 2011/09/03 06:00
CRDT- 2011/05/12 06:00
PHST- 2011/05/12 06:00 [entrez]
PHST- 2011/05/12 06:00 [pubmed]
PHST- 2011/09/03 06:00 [medline]
AID - en.2010-1256 [pii]
AID - 10.1210/en.2010-1256 [doi]
PST - ppublish
SO  - Endocrinology. 2011 Jul;152(7):2845-56. doi: 10.1210/en.2010-1256. Epub 2011 May 
      10.


PMID- 21558120
OWN - NLM
STAT- MEDLINE
DCOM- 20110914
LR  - 20110511
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 3
DP  - 2011 May
TI  - Questions for debate. What is the role of moral theory in everyday nursing
      ethics? Is it right that Research Ethics Committees make judgements about the
      scientific quality of research proposals?
PG  - 460-3
LID - 10.1177/0969733011404112 [doi]
FAU - Edwards, Steve
AU  - Edwards S
AD  - University of Swansea, Wales.
FAU - Woods, Martin
AU  - Woods M
FAU - Humphreys, Stephen
AU  - Humphreys S
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Biomedical Research/*standards
MH  - *Ethics Committees
MH  - *Ethics, Nursing
MH  - Humans
MH  - *Morals
MH  - Nursing Care/*ethics
EDAT- 2011/05/12 06:00
MHDA- 2011/09/15 06:00
CRDT- 2011/05/12 06:00
PHST- 2011/05/12 06:00 [entrez]
PHST- 2011/05/12 06:00 [pubmed]
PHST- 2011/09/15 06:00 [medline]
AID - 18/3/460 [pii]
AID - 10.1177/0969733011404112 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 May;18(3):460-3. doi: 10.1177/0969733011404112.


PMID- 21558119
OWN - NLM
STAT- MEDLINE
DCOM- 20110914
LR  - 20110511
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 3
DP  - 2011 May
TI  - Educational content in nurse education in Japan: a Delphi study.
PG  - 441-54
LID - 10.1177/0969733010385530 [doi]
AB  - The purpose of this study was to clarify the minimum necessary educational
      content in the area of nursing ethics in a basic nursing education program, and
      the level of students' mastery of this content, based on a Delphi study in both
      educational and clinical settings. A Delphi study was conducted in three rounds
      with faculty members who teach nursing ethics at all 158 four-year nursing
      universities in Japan as targeted panelists. In this study the opinions on
      nursing ethics of nursing instructors responsible for hospital education at all
      82 special functioning hospitals were reflected in the panelists' opinions.
      Consensus was obtained on 41 items from a total of 63 items in 4 proposed
      frameworks. There were 20 items related to the Concept of nursing ethics, 7 items
      related to Ethical codes, 13 items related to Ethical issues and methods to
      resolve them, and 1 item related to Efforts and issues in practical and
      educational settings. Consensus as to desired level of mastery was reached on a
      total of 40 items. This agreed-upon level involved understanding of the concept
      for 22 items, the ability to explain the concept for 16 items, and the ability to
      act based on the concept for 2 items.
CI  - (c) The Author(s) 2011
FAU - Ito, Chiharu
AU  - Ito C
AD  - Chubu University, Kasugai, Aichi 487-8501, Japan. cito@isc.chubu.ac.jp
FAU - Ota, Katsumasa
AU  - Ota K
FAU - Matsuda, Masami
AU  - Matsuda M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Curriculum
MH  - Delphi Technique
MH  - *Education, Nursing, Baccalaureate
MH  - Ethics, Nursing/*education
MH  - Humans
MH  - Japan
EDAT- 2011/05/12 06:00
MHDA- 2011/09/15 06:00
CRDT- 2011/05/12 06:00
PHST- 2011/05/12 06:00 [entrez]
PHST- 2011/05/12 06:00 [pubmed]
PHST- 2011/09/15 06:00 [medline]
AID - 18/3/441 [pii]
AID - 10.1177/0969733010385530 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 May;18(3):441-54. doi: 10.1177/0969733010385530.


PMID- 21558117
OWN - NLM
STAT- MEDLINE
DCOM- 20110914
LR  - 20220321
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 3
DP  - 2011 May
TI  - Blended learning in ethics education: a survey of nursing students.
PG  - 418-30
LID - 10.1177/0969733011398097 [doi]
AB  - Nurses are experiencing new ethical issues as a result of global developments and
      changes in health care. With health care becoming increasingly sophisticated, and
      countries facing challenges of graying population, ethical issues involved in
      health care are bound to expand in quantity and in depth. Blended learning rather
      as a combination of multiple delivery media designed to promote meaningful
      learning. Specifically, this study was focused on two questions: (1) the
      students' satisfaction and attitudes as members of a scenario-based learning
      process in a blended learning environment; (2) the relationship between students'
      satisfaction ratings of nursing ethics course and their attitudes in the blended 
      learning environment. In total, 99 senior undergraduate nursing students
      currently studying at a public nursing college in Taiwan were invited to
      participate in this study. A cross-sectional survey design was adopted in this
      study. The participants were asked to fill out two Likert-scale questionnaire
      surveys: CAAS (Case Analysis Attitude Scale), and BLSS (Blended Learning
      Satisfaction Scale). The results showed what students felt about their blended
      learning experiences - mostly items ranged from 3.27-3.76 (the highest score is
      5). Another self-assessment of scenario analysis instrument revealed the mean
      scores ranged from 2.87-4.19. Nearly 57.8% of the participants rated the course
      'extremely helpful' or 'very helpful.' This study showed statistically
      significant correlations (r=0.43) between students' satisfaction with blended
      learning and case analysis attitudes. In addition, results testified to a
      potential of the blended learning model proposed in this study to bridge the gap 
      between students and instructors and the one between students and their peers,
      which are typical of blended learning, and to create meaningful learning by
      employing blended pedagogical consideration in the course design. The use of
      scenario instruction enables students to develop critical analysis and problem
      solving skills through active learning and social exchange of ideas.
CI  - (c) The Author(s) 2011
FAU - Hsu, Li-Ling
AU  - Hsu LL
AD  - Graduate Program Health Allied Education, National Taipei University of Nursing
      and Health Sciences, No. 365, Ming-Te Rd., Peitou 112, Taipei, Taiwan, ROC.
      hsu.liling@msa.hinet.net
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Computer-Assisted Instruction
MH  - Education, Nursing, Baccalaureate/*methods
MH  - Ethics, Nursing/*education
MH  - Female
MH  - Humans
MH  - Students, Nursing/*psychology
MH  - Surveys and Questionnaires
MH  - Taiwan
MH  - Young Adult
EDAT- 2011/05/12 06:00
MHDA- 2011/09/15 06:00
CRDT- 2011/05/12 06:00
PHST- 2011/05/12 06:00 [entrez]
PHST- 2011/05/12 06:00 [pubmed]
PHST- 2011/09/15 06:00 [medline]
AID - 18/3/418 [pii]
AID - 10.1177/0969733011398097 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 May;18(3):418-30. doi: 10.1177/0969733011398097.


PMID- 21558116
OWN - NLM
STAT- MEDLINE
DCOM- 20110914
LR  - 20110511
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 3
DP  - 2011 May
TI  - Home-based nursing: an endless journey.
PG  - 408-17
LID - 10.1177/0969733011398098 [doi]
AB  - The aim of this study was to explore metaphors for discovering values and norms
      held by nurses in home-based nursing care. Ten interviews were analysed and
      interpreted in accordance with a metaphor analytical method. In the analysis,
      metaphoric linguistic expressions and two entailments emerged, grounded in the
      conceptual metaphor 'home-based nursing care is an endless journey', which were
      created in a cross-domain mapping between the two conceptual domains of
      home-based nursing care and travel. The metaphor exposed home-based nursing care 
      as being in constant motion, thereby requiring nurses to adjust to circumstances 
      that demand ethical maturity. The study focuses on the importance of developing
      further theories supporting nurses' expressions of their experiences of everyday 
      ethical issues.
CI  - (c) The Author(s) 2011
FAU - Oresland, Stina
AU  - Oresland S
AD  - Umea University, Sweden. stina.oresland@hibu.no
FAU - Maatta, Sylvia
AU  - Maatta S
FAU - Norberg, Astrid
AU  - Norberg A
FAU - Lutzen, Kim
AU  - Lutzen K
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Adult
MH  - Attitude of Health Personnel
MH  - Female
MH  - *Home Care Services, Hospital-Based
MH  - Humans
MH  - Male
MH  - Metaphor
MH  - Middle Aged
MH  - Nursing Care/*psychology
MH  - Sweden
MH  - Travel
EDAT- 2011/05/12 06:00
MHDA- 2011/09/15 06:00
CRDT- 2011/05/12 06:00
PHST- 2011/05/12 06:00 [entrez]
PHST- 2011/05/12 06:00 [pubmed]
PHST- 2011/09/15 06:00 [medline]
AID - 18/3/408 [pii]
AID - 10.1177/0969733011398098 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 May;18(3):408-17. doi: 10.1177/0969733011398098.


PMID- 21558115
OWN - NLM
STAT- MEDLINE
DCOM- 20110914
LR  - 20110511
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 3
DP  - 2011 May
TI  - Feminist intersectionality: bringing social justice to health disparities
      research.
PG  - 397-407
LID - 10.1177/0969733011398094 [doi]
AB  - The principles of autonomy, beneficence, non-maleficence, and justice are well
      established ethical principles in health research. Of these principles, justice
      has received less attention by health researchers. The purpose of this article is
      to broaden the discussion of health research ethics, particularly the ethical
      principle of justice, to include societal considerations--who and what are
      studied and why?--and to critique current applications of ethical principles
      within this broader view. We will use a feminist intersectional approach in the
      context of health disparities research to firmly establish inseparable links
      between health research ethics, social action, and social justice. The aim is to 
      provide an ethical approach to health disparities research that simultaneously
      describes and seeks to eliminate health disparities.
CI  - (c) The Author(s) 2011
FAU - Rogers, Jamie
AU  - Rogers J
AD  - School of Nursing, The University of North Carolina at Chapel Hill, Carrington
      Hall, Campus Box 7460, Chapel Hill, NC 27599-7460, USA. jrogers3@email.unc.edu
FAU - Kelly, Ursula A
AU  - Kelly UA
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - *Bioethical Issues
MH  - Female
MH  - *Feminism
MH  - Health Services Research/*ethics
MH  - *Healthcare Disparities/ethics
MH  - Humans
MH  - Male
MH  - *Social Justice
EDAT- 2011/05/12 06:00
MHDA- 2011/09/15 06:00
CRDT- 2011/05/12 06:00
PHST- 2011/05/12 06:00 [entrez]
PHST- 2011/05/12 06:00 [pubmed]
PHST- 2011/09/15 06:00 [medline]
AID - 18/3/397 [pii]
AID - 10.1177/0969733011398094 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 May;18(3):397-407. doi: 10.1177/0969733011398094.


PMID- 21558114
OWN - NLM
STAT- MEDLINE
DCOM- 20110914
LR  - 20181201
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 3
DP  - 2011 May
TI  - Rationing home-based nursing care: professional ethical implications.
PG  - 386-96
LID - 10.1177/0969733011398099 [doi]
AB  - The purpose of this study was to investigate nurses' decisions about priorities
      in home-based nursing care. Qualitative research interviews were conducted with
      17 nurses in home-based care. The interviews were analyzed and interpreted
      according to a hermeneutic methodology. Nurses describe clinical priorities in
      home-based care as rationing care to mind the gap between an extensive workload
      and staff shortages. By organizing home-based care according to tight time
      schedules, the nurses' are able to provide care for as many patients as possible.
      Furthermore, legal norms set boundaries for clinical priority decisions,
      resulting in marginalized care. Hence, rationing care jeopardizes important
      values in the nurse-patient relationship, in particular the value of
      individualized and inclusive nursing care. The findings are highly relevant for
      clinical practice, since they have major implications for provision of nursing
      care. They revive debates about the protection of values and standards of care,
      and nurses' role and responsibility when resources are limited.
CI  - (c) The Author(s) 2011
FAU - Tonnessen, Siri
AU  - Tonnessen S
AD  - Department of Health and Social Sciences, Harstad University College, Harstad -
      N-9480, Norway. siri.tonnessen@hih.no
FAU - Nortvedt, Per
AU  - Nortvedt P
FAU - Forde, Reidun
AU  - Forde R
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Health Care Rationing/*ethics
MH  - *Home Care Services, Hospital-Based
MH  - Humans
MH  - Norway
MH  - Nursing Care/*ethics/organization & administration
MH  - Workforce
EDAT- 2011/05/12 06:00
MHDA- 2011/09/15 06:00
CRDT- 2011/05/12 06:00
PHST- 2011/05/12 06:00 [entrez]
PHST- 2011/05/12 06:00 [pubmed]
PHST- 2011/09/15 06:00 [medline]
AID - 18/3/386 [pii]
AID - 10.1177/0969733011398099 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 May;18(3):386-96. doi: 10.1177/0969733011398099.


PMID- 21558112
OWN - NLM
STAT- MEDLINE
DCOM- 20110914
LR  - 20151119
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 3
DP  - 2011 May
TI  - Placebo use in clinical practice by nurses in an Iranian teaching hospital.
PG  - 364-73
LID - 10.1177/0969733011398093 [doi]
AB  - The present study was carried out to explore Iranian nurses' use of placebos in
      clinical practice and their knowledge and attitude towards its use. A
      cross-sectional, descriptive study was conducted using self-report
      questionnaires. All nurses working in a university hospital in Arak (n=342) were 
      invited to participate in the study. Among 295 respondents, 221 (75%) reported
      that they had used at least one placebo within the past year and 179 (81%) told
      patients they were receiving actual medication. The most common reason and
      symptom for placebo use were after unjustified demand for medication and pain,
      respectively. Only 60 (20.33%) of the nurses believed that placebos should never 
      be used. Results showed that most nurses in our study had used placebos and
      probably will continue to use them. Placebo use is viewed as ethically
      permissible among nurses. Some patients benefit from the placebos, but their use 
      raises ethical questions. The role of placebo treatment, its mechanisms, and its 
      ethics issues should be taught to nurses.
CI  - (c) The Author(s) 2011
FAU - Baghcheghi, Nayereh
AU  - Baghcheghi N
AD  - Arak University of Medical Sciences, Basij SQ, Sardasht, Arak, Islamic Republic
      of Iran.
FAU - Koohestani, Hamid Reza
AU  - Koohestani HR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
RN  - 0 (Placebos)
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Female
MH  - *Hospitals, University
MH  - Humans
MH  - Iran
MH  - Male
MH  - Middle Aged
MH  - Nursing Care/*ethics
MH  - Nursing Staff, Hospital/*ethics
MH  - Placebos/*therapeutic use
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2011/05/12 06:00
MHDA- 2011/09/15 06:00
CRDT- 2011/05/12 06:00
PHST- 2011/05/12 06:00 [entrez]
PHST- 2011/05/12 06:00 [pubmed]
PHST- 2011/09/15 06:00 [medline]
AID - 18/3/364 [pii]
AID - 10.1177/0969733011398093 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 May;18(3):364-73. doi: 10.1177/0969733011398093.


PMID- 21558110
OWN - NLM
STAT- MEDLINE
DCOM- 20110914
LR  - 20151119
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 3
DP  - 2011 May
TI  - How nurses and physicians face ethical dilemmas--the Croatian experience.
PG  - 341-55
LID - 10.1177/0969733011398095 [doi]
AB  - The aim of this study was to assess nurses' and physicians' ethical dilemmas in
      clinical practice. Nurses and physicians of the Clinical Hospital Centre Rijeka
      were surveyed (N=364). A questionnaire was used to identify recent ethical
      dilemma, primary ethical issue in the situation, satisfaction with the
      resolution, perceived usefulness of help, and usage of clinical ethics
      consultations in practice. Recent ethical dilemmas include professional conduct
      for nurses (8%), and near-the-end-of-life decisions for physicians (27%). The
      main ethical issue is limiting life-sustaining therapy (nurses 15%, physicians
      24%) and euthanasia and physician-assisted suicide (nurses 16%, physicians 9%).
      The types of help available are similar for nurses and physicians: obtaining
      complete information about the patient (37% vs. 50%) and clarifying ethical
      issues (31% vs. 39%). Nurses and physicians experience similar ethical dilemmas
      in clinical practice. The usage of clinical ethics consultations is low. It is
      recommended that the individual and team consultations should be introduced in
      Croatian clinical ethics consultations services.
CI  - (c) The Author(s) 2011
FAU - Sorta-Bilajac, Iva
AU  - Sorta-Bilajac I
AD  - Department of Social Sciences and Medical Humanities, University of Rijeka -
      School of Medicine, B. Branchetta 20, 51 000 Rijeka, Croatia. iva.sorta@medri.hr
FAU - Bazdaric, Ksenija
AU  - Bazdaric K
FAU - Zagrovic, Morana Brkljacic
AU  - Zagrovic MB
FAU - Jancic, Ervin
AU  - Jancic E
FAU - Brozovic, Boris
AU  - Brozovic B
FAU - Cengic, Tomislav
AU  - Cengic T
FAU - Corluka, Stipe
AU  - Corluka S
FAU - Agich, George J
AU  - Agich GJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Adult
MH  - Attitude of Health Personnel
MH  - *Bioethical Issues
MH  - Croatia
MH  - Ethics Consultation
MH  - Ethics, Medical
MH  - Ethics, Nursing
MH  - Euthanasia/ethics
MH  - Female
MH  - Humans
MH  - Male
MH  - Medical Staff, Hospital/*ethics
MH  - Middle Aged
MH  - Nursing Staff, Hospital/*ethics
MH  - Surveys and Questionnaires
MH  - Terminal Care
MH  - Young Adult
EDAT- 2011/05/12 06:00
MHDA- 2011/09/15 06:00
CRDT- 2011/05/12 06:00
PHST- 2011/05/12 06:00 [entrez]
PHST- 2011/05/12 06:00 [pubmed]
PHST- 2011/09/15 06:00 [medline]
AID - 18/3/341 [pii]
AID - 10.1177/0969733011398095 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 May;18(3):341-55. doi: 10.1177/0969733011398095.


PMID- 21558109
OWN - NLM
STAT- MEDLINE
DCOM- 20110914
LR  - 20110511
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 3
DP  - 2011 May
TI  - Organizing moral case deliberation experiences in two Dutch nursing homes.
PG  - 327-40
LID - 10.1177/0969733011400299 [doi]
AB  - Moral case deliberation (MCD) is a specific form of clinical ethics, aiming to
      stimulate ethical reflection in daily practice in order to improve the quality of
      care. This article focuses on the implementation of MCD in nursing homes and the 
      questions how and where to organize MCD. The purpose of this study was to
      evaluate one way of organizing MCD in two Dutch nursing homes. In both of these
      nursing homes the MCD groups had a heterogeneous composition and were organized
      apart from existing institutional communication structures. As part of a
      naturalistic evaluation, systematic observations, interviews and focus groups
      were completed. The findings indicate that the heterogeneous composition and MCD 
      meetings separate from existing structures have benefits. However, the
      participants also reported negative experiences. This gives rise to the question 
      whether a mixed MCD group which meets separately is an effective way to embed MCD
      as an instrument for reflection on moral issues in daily practice. We conclude
      that there is no single answer to that question. In the end, the two
      implementation strategies (i.e. within existing communication structures and a
      mixed MCD group) can be complementary to each other.
CI  - (c) The Author(s) 2011
FAU - van der Dam, S Sandra
AU  - van der Dam SS
AD  - Department of Health, Ethics and Society, Maastricht University/CAPHRI, The
      Netherlands. s.vanderdam@hes.unimaas.nl
FAU - Abma, T A Tineke
AU  - Abma TA
FAU - Molewijk, A C Bert
AU  - Molewijk AC
FAU - Kardol, M J M Tinie
AU  - Kardol MJ
FAU - Schols, J M G A Jos
AU  - Schols JM
FAU - Widdershoven, G A M Guy
AU  - Widdershoven GA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Ethics Consultation
MH  - *Ethics, Clinical
MH  - Group Processes
MH  - Humans
MH  - *Interdisciplinary Communication
MH  - Netherlands
MH  - Nursing Homes/*ethics
MH  - Quality of Health Care/*ethics
EDAT- 2011/05/12 06:00
MHDA- 2011/09/15 06:00
CRDT- 2011/05/12 06:00
PHST- 2011/05/12 06:00 [entrez]
PHST- 2011/05/12 06:00 [pubmed]
PHST- 2011/09/15 06:00 [medline]
AID - 18/3/327 [pii]
AID - 10.1177/0969733011400299 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 May;18(3):327-40. doi: 10.1177/0969733011400299.


PMID- 21558108
OWN - NLM
STAT- MEDLINE
DCOM- 20110914
LR  - 20220318
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 3
DP  - 2011 May
TI  - Burnout in palliative care: a systematic review.
PG  - 317-26
LID - 10.1177/0969733011398092 [doi]
AB  - Burnout is a phenomenon characterized by fatigue and frustration, usually related
      to work stress and dedication to a cause, a way of life that does not match the
      person's expectations. Although it seems to be associated with risk factors
      stemming from a professional environment, this problem may affect any person.
      Palliative care is provided in a challenging environment, where professionals
      often have to make demanding ethical decisions and deal with death and dying.
      This article reports on the findings of a systematic review aimed at identifying 
      described burnout levels in palliative care nurses and physicians, and the
      related risks and protective factors. The main findings indicate that burnout
      levels in palliative care, or in health care settings related to this field, do
      not seem to be higher than in other contexts.
CI  - (c) The Author(s) 2011
FAU - Pereira, Sandra Martins
AU  - Pereira SM
AD  - Universidade dos Acores, Portugal. smpereira@uac.pt
FAU - Fonseca, Antonio M
AU  - Fonseca AM
FAU - Carvalho, Ana Sofia
AU  - Carvalho AS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Burnout, Professional/*etiology/psychology
MH  - Humans
MH  - Nurses/*psychology
MH  - Palliative Care/*psychology
MH  - Physicians/psychology
MH  - Portugal
MH  - Terminal Care/*psychology
EDAT- 2011/05/12 06:00
MHDA- 2011/09/15 06:00
CRDT- 2011/05/12 06:00
PHST- 2011/05/12 06:00 [entrez]
PHST- 2011/05/12 06:00 [pubmed]
PHST- 2011/09/15 06:00 [medline]
AID - 18/3/317 [pii]
AID - 10.1177/0969733011398092 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 May;18(3):317-26. doi: 10.1177/0969733011398092.


PMID- 21558107
OWN - NLM
STAT- MEDLINE
DCOM- 20110914
LR  - 20181201
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 3
DP  - 2011 May
TI  - Moral margins concerning the use of coercion in psychiatry.
PG  - 304-16
LID - 10.1177/0969733011400301 [doi]
AB  - In the closed wards of mental health institutions, moral decisions are made
      concerning the use of forced seclusion. In this article we focus on how these
      moral decisions are made and can be improved. We present a case study concerning 
      moral deliberations on the use of seclusion and its prevention among nurses of a 
      closed mental health ward. Moral psychology provides an explanation of how moral 
      judgments are developed through processes of interaction. We will make use of the
      Social Intuitionist Model of Jonathan Haidt that emphasizes the role of emotions,
      intuitions and the social context in moral judgments and reasoning. We argue that
      this model can help to explain social dynamics in the context of enforced
      seclusion. In the discussion we explore how moral psychology can be complemented 
      with the normative perspective of dialogical ethics to develop strategies for
      improving psychiatric practices. We conclude that social processes play an
      important role in moral deliberations and that moral development can be fostered 
      by bringing in new perspectives in the dialogue. Moral case deliberation provides
      a practical tool to systematically organize moral reflections among nurses on the
      work floor.
CI  - (c) The Author(s) 2011
FAU - Landeweer, Elleke G M
AU  - Landeweer EG
AD  - VU University Medical Centre, Department of Medical Humanities, Van der
      Boechorststraat 7, 1081 BT Amsterdam, The Netherlands. e.landeweer@vumc.nl
FAU - Abma, Tineke A
AU  - Abma TA
FAU - Widdershoven, Guy A M
AU  - Widdershoven GA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Adolescent
MH  - Adult
MH  - *Coercion
MH  - Female
MH  - Hospitals, Psychiatric
MH  - Humans
MH  - Male
MH  - *Morals
MH  - Netherlands
MH  - Organizational Culture
MH  - Patient Isolation/*ethics/statistics & numerical data
MH  - Psychiatric Nursing/*ethics
MH  - Safety Management/*ethics
MH  - *Violence
EDAT- 2011/05/12 06:00
MHDA- 2011/09/15 06:00
CRDT- 2011/05/12 06:00
PHST- 2011/05/12 06:00 [entrez]
PHST- 2011/05/12 06:00 [pubmed]
PHST- 2011/09/15 06:00 [medline]
AID - 18/3/304 [pii]
AID - 10.1177/0969733011400301 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 May;18(3):304-16. doi: 10.1177/0969733011400301.


PMID- 21558106
OWN - NLM
STAT- MEDLINE
DCOM- 20110914
LR  - 20220330
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 3
DP  - 2011 May
TI  - Organizational ethics: a literature review.
PG  - 285-303
LID - 10.1177/0969733011401123 [doi]
AB  - The aim of the study was to report the results of a systematically conducted
      literature review of empirical studies about healthcare organizations' ethics and
      management or leadership issues. Electronic databases MEDLINE and CINAHL yielded 
      909 citations. After a two stage application of the inclusion and exclusion
      criteria 56 full-text articles were included in the review. No large research
      programs were identified. Most of the studies were in acute hospital settings
      from the 1990s onwards. The studies focused on ethical challenges, dilemmas in
      practice, employee moral distress and ethical climates or environments. Study
      samples typically consisted of healthcare practitioners, operational, executive
      and strategic managers. Data collection was mainly by questionnaires or
      interviews and most of the studies were descriptive, correlational and
      cross-sectional. There is need to develop conceptual clarity and a theoretical
      framework around the subject of organizational ethics and the breadth of the
      contexts and scope of the research needs to be increased.
CI  - (c) The Author(s) 2011
FAU - Suhonen, Riitta
AU  - Suhonen R
AD  - University of Turku, Department of Nursing Science, Lemminkaisenkatu 1, 2 krs.,
      20014 University of Turku, Finland. riisuh@utu.fi
FAU - Stolt, Minna
AU  - Stolt M
FAU - Virtanen, Heli
AU  - Virtanen H
FAU - Leino-Kilpi, Helena
AU  - Leino-Kilpi H
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - *Ethics, Institutional
MH  - Humans
MH  - Personnel, Hospital/ethics
EDAT- 2011/05/12 06:00
MHDA- 2011/09/15 06:00
CRDT- 2011/05/12 06:00
PHST- 2011/05/12 06:00 [entrez]
PHST- 2011/05/12 06:00 [pubmed]
PHST- 2011/09/15 06:00 [medline]
AID - 18/3/285 [pii]
AID - 10.1177/0969733011401123 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 May;18(3):285-303. doi: 10.1177/0969733011401123.


PMID- 21557815
OWN - NLM
STAT- MEDLINE
DCOM- 20110906
LR  - 20151026
IS  - 1747-4949 (Electronic)
IS  - 1747-4930 (Linking)
VI  - 6
IP  - 3
DP  - 2011 Jun
TI  - The rationale and design of the Giant Intracranial Aneurysm Registry: a
      retrospective and prospective study.
PG  - 266-70
LID - 10.1111/j.1747-4949.2011.00588.x [doi]
AB  - AIMS AND HYPOTHESIS: Giant intracranial aneurysms have a poor prognosis mainly
      due to their high risk of rupture. Because their incidence is low, clinical trial
      evidence for adequate treatment is lacking. The Giant Intracranial Aneurysm
      Registry is designed to document current treatment strategies in giant aneurysm
      care and to monitor the course of the disease over five-years. It aims to
      evaluate the hypothesis that all three possible branches of therapy
      (conservative/endovascular/surgical) lead to equal rupture rates. DESIGN: The
      Giant Intracranial Aneurysm Registry is an interdisciplinary multicenter
      observational study. Each center recruits patients diagnosed with a giant
      intracranial aneurysm both prospectively and retrospectively. Primary outcome
      will be the aneurysm rupture rate at five-years of follow-up. STUDY OUTCOME:
      Patient enrollment has begun at 20 neurovascular centers throughout Germany, with
      19 further centers applying for local ethics approval to take part in the study. 
      The first nine months are designed as a pilot phase followed by the integration
      of study centers throughout the EU and the initiation of separate sub-studies.
      DISCUSSION: Giant intracranial aneurysms have often been ignored or marginalized 
      due to their low incidence. The Giant Intracranial Aneurysm Registry aims to lead
      to a better understanding of these complex lesions and to serve as a basis for
      the development of future clinical studies.
CI  - (c) 2011 The Authors. International Journal of Stroke (c) 2011 World Stroke
      Organization.
FAU - Dengler, Julius
AU  - Dengler J
AD  - Department of Neurosurgery, Charite, Universitaetsmedizin Berlin, CVK, Berlin,
      Germany.
FAU - Heuschmann, Peter U
AU  - Heuschmann PU
FAU - Endres, Matthias
AU  - Endres M
FAU - Meyer, Bernhard
AU  - Meyer B
FAU - Rohde, Veit
AU  - Rohde V
FAU - Rufenacht, Daniel A
AU  - Rufenacht DA
FAU - Vajkoczy, Peter
AU  - Vajkoczy P
CN  - Giant Intracranial Aneurysm Study Group
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20110407
PL  - United States
TA  - Int J Stroke
JT  - International journal of stroke : official journal of the International Stroke
      Society
JID - 101274068
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aneurysm, Ruptured/pathology
MH  - Female
MH  - Follow-Up Studies
MH  - Germany
MH  - Humans
MH  - Intracranial Aneurysm/mortality/*pathology/therapy
MH  - Male
MH  - Middle Aged
MH  - Patient Selection
MH  - Prognosis
MH  - Prospective Studies
MH  - *Registries
MH  - Retrospective Studies
MH  - Sample Size
MH  - Treatment Outcome
MH  - Young Adult
IR  - Behnke-Mursch J
FIR - Behnke-Mursch, J
IR  - Mursch K
FIR - Mursch, K
IR  - Grote A
FIR - Grote, A
IR  - Schramm J
FIR - Schramm, J
IR  - Simon M
FIR - Simon, M
IR  - Endres M
FIR - Endres, M
IR  - Grawe A
FIR - Grawe, A
IR  - Heuschmann P
FIR - Heuschmann, P U
IR  - Hosch H
FIR - Hosch, H
IR  - Joedicke A
FIR - Joedicke, A
IR  - Meier U
FIR - Meier, U
IR  - Moskopp D
FIR - Moskopp, D
IR  - Dengler J
FIR - Dengler, J
IR  - Vajkoczy P
FIR - Vajkoczy, P
IR  - Al-Amin A
FIR - Al-Amin, A
IR  - Fiss I
FIR - Fiss, I
IR  - Schultheiss R
FIR - Schultheiss, R
IR  - Eicker S
FIR - Eicker, S
IR  - Haenggi D
FIR - Haenggi, D
IR  - Steiger H
FIR - Steiger, H J
IR  - Turowski B
FIR - Turowski, B
IR  - Ardeshiri A
FIR - Ardeshiri, A
IR  - Sure U
FIR - Sure, U
IR  - Boerm W
FIR - Boerm, W
IR  - Riis P
FIR - Riis, P
IR  - Glaesker S
FIR - Glaesker, S
IR  - Van Velthoven V
FIR - Van Velthoven, V
IR  - Zentner J
FIR - Zentner, J
IR  - Bijlenga P
FIR - Bijlenga, P
IR  - Schaller K
FIR - Schaller, K
IR  - Rohde V
FIR - Rohde, V
IR  - Wachter D
FIR - Wachter, D
IR  - Guhl S
FIR - Guhl, S
IR  - Schroeder H
FIR - Schroeder, H
IR  - Hohaus C
FIR - Hohaus, C
IR  - Meisel HJ
FIR - Meisel, H J
IR  - Strauss C
FIR - Strauss, C
IR  - Regelsberger J
FIR - Regelsberger, J
IR  - Schmidt N
FIR - Schmidt, N
IR  - Westphal M
FIR - Westphal, M
IR  - Hong B
FIR - Hong, B
IR  - Krauss J
FIR - Krauss, J K
IR  - Nakamura M
FIR - Nakamura, M
IR  - Jung C
FIR - Jung, C
IR  - Unterberg A
FIR - Unterberg, A
IR  - Spetzger U
FIR - Spetzger, U
IR  - Winkler G
FIR - Winkler, G
IR  - Hoffmann K
FIR - Hoffmann, K T
IR  - Braunsdorf W
FIR - Braunsdorf, W
IR  - Barth M
FIR - Barth, M
IR  - Schmieder K
FIR - Schmieder, K
IR  - Lehmberg J
FIR - Lehmberg, J
IR  - Liebig T
FIR - Liebig, T
IR  - Lumenta C
FIR - Lumenta, C
IR  - Meyer B
FIR - Meyer, B
IR  - Roetzer S
FIR - Roetzer, S
IR  - Wostrack M
FIR - Wostrack, M
IR  - Jaksche H
FIR - Jaksche, H
IR  - Strowitzki M
FIR - Strowitzki, M
IR  - Brawanski A
FIR - Brawanski, A
IR  - Schebesch K
FIR - Schebesch, K M
IR  - Piek J
FIR - Piek, J
IR  - Stockhammer F
FIR - Stockhammer, F
IR  - Hopf N
FIR - Hopf, N
IR  - Musahl C
FIR - Musahl, C
IR  - Krischek B
FIR - Krischek, B
IR  - Tatagiba M
FIR - Tatagiba, M
IR  - Koenig R
FIR - Koenig, R
IR  - Wirtz R
FIR - Wirtz, R
IR  - Rufenacht D
FIR - Rufenacht, D A
IR  - Beckert M
FIR - Beckert, M
IR  - Warnke J
FIR - Warnke, J
EDAT- 2011/05/12 06:00
MHDA- 2011/09/07 06:00
CRDT- 2011/05/12 06:00
PHST- 2011/05/12 06:00 [entrez]
PHST- 2011/05/12 06:00 [pubmed]
PHST- 2011/09/07 06:00 [medline]
AID - 10.1111/j.1747-4949.2011.00588.x [doi]
PST - ppublish
SO  - Int J Stroke. 2011 Jun;6(3):266-70. doi: 10.1111/j.1747-4949.2011.00588.x. Epub
      2011 Apr 7.


PMID- 21556910
OWN - NLM
STAT- MEDLINE
DCOM- 20111227
LR  - 20220318
IS  - 1432-1084 (Electronic)
IS  - 0938-7994 (Linking)
VI  - 21
IP  - 9
DP  - 2011 Sep
TI  - Ultrasound features of malignancy in the preoperative diagnosis of parathyroid
      cancer: a retrospective analysis of parathyroid tumours larger than 15 mm.
PG  - 1865-73
LID - 10.1007/s00330-011-2141-3 [doi]
AB  - OBJECTIVE: Nearly all reported parathyroid cancers are >15 mm at presentation.
      The objective was to identify ultrasound criteria of malignancy in parathyroid
      lesions of >15 mm in size. MATERIALS AND METHODS: This study was approved by a
      local ethics committee. A retrospective review of patients identified from a
      database from 2004-2009 was performed. All patients underwent ultrasound imaging 
      according to the protocol. Two trained observers categorized findings using the
      pre-determined features: shape, calcification, pattern of vascularity, local
      infiltration and internal lesion gray scale appearances. RESULTS: Sixty-nine
      patients (mean age 54.3 years, range 19-79 years; male = 16, female = 53)
      fulfilled the criteria of a parathyroid lesion >15 mm; 8/69 (11.6%) with
      parathyroid cancer and 61/69 (88.4%) with benign solitary parathyroid adenoma. A 
      high positive predictive value (PPV) for cancer was identified for infiltration
      (PPV 100%) and calcification (PPV 100%), whilst a high negative predictive value 
      (NPV) was found for the absence of suspicious vascularity (NPV 97.6%), a thick
      capsule (NPV 96.7) and inhomogeneity (NPV 100%). CONCLUSION: In lesions >15 mm
      systematic ultrasound assessment of specific features provides a valuable tool to
      identify parathyroid cancers before surgery.
FAU - Sidhu, Paul S
AU  - Sidhu PS
AD  - Department of Radiology, King's College Hospital, King's Health Partners, London,
      UK.
FAU - Talat, Nadia
AU  - Talat N
FAU - Patel, Preena
AU  - Patel P
FAU - Mulholland, Nicola J
AU  - Mulholland NJ
FAU - Schulte, Klaus-Martin
AU  - Schulte KM
LA  - eng
PT  - Journal Article
DEP - 20110510
PL  - Germany
TA  - Eur Radiol
JT  - European radiology
JID - 9114774
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cohort Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Invasiveness/pathology
MH  - Neoplasm Staging
MH  - Parathyroid Glands/*diagnostic imaging/*pathology
MH  - Parathyroid Neoplasms/diagnosis/*diagnostic imaging/*surgery
MH  - Parathyroidectomy/methods
MH  - Preoperative Care/methods
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Treatment Outcome
MH  - Tumor Burden
MH  - Ultrasonography, Doppler, Color/*methods
MH  - Young Adult
EDAT- 2011/05/11 06:00
MHDA- 2011/12/28 06:00
CRDT- 2011/05/11 06:00
PHST- 2011/01/07 00:00 [received]
PHST- 2011/03/19 00:00 [accepted]
PHST- 2011/02/28 00:00 [revised]
PHST- 2011/05/11 06:00 [entrez]
PHST- 2011/05/11 06:00 [pubmed]
PHST- 2011/12/28 06:00 [medline]
AID - 10.1007/s00330-011-2141-3 [doi]
PST - ppublish
SO  - Eur Radiol. 2011 Sep;21(9):1865-73. doi: 10.1007/s00330-011-2141-3. Epub 2011 May
      10.


PMID- 21556472
OWN - NLM
STAT- MEDLINE
DCOM- 20111013
LR  - 20191210
IS  - 0379-5284 (Print)
IS  - 0379-5284 (Linking)
VI  - 32
IP  - 5
DP  - 2011 May
TI  - Repair of large abdominal wall defects using the Proceed surgical mesh with open 
      intra-peritonium onlay method.
PG  - 504-9
AB  - OBJECTIVE: To report our experience with the use of Proceed, Ethicon,
      Norderstedt, Germany surgical mesh in the management of large abdominal wall
      defects with the open intra-peritonium onlay method. METHODS: Thirty-six patients
      with large incisional hernia or defects resulting from tumor resection carried
      out at the Department of General Surgery, the First Affiliated Hospital, General 
      Hospital of People's Liberation Army, China between May 2007 and June 2010 were
      studied. The abdominal wall defect was repaired using Proceed mesh with the
      intra-peritonium onlay method. Different parameters were evaluated considering
      the complications such as seroma, hematoma, wound infection, mesh infection,
      chronic pain, wound sinus, and recurrences. RESULTS: All 36 defects were repaired
      using Proceed mesh. The mean size of the defects was 160 cm2 (range = 120-600
      cm2). Eleven patients (30.6%) developed a complication (6 seromas, one minor
      wound infection, one wound sinus, 2 pulmonary infection, and one urinary tract
      infection). The mean follow-up period was 28 months (range 6-36 months). There
      were no cases of intestinal fistula or problems related to intestinal adhesion
      and chronic wound pain. No hernia recurrence, or mesh infection occurred.
      CONCLUSION: The intra-peritoneum repair technique for a large abdominal wall
      defect using Proceed mesh is a feasible and safe method, with no major
      complications.
FAU - Liu, Feide
AU  - Liu F
AD  - Department of General Surgery, General Hospital of PLA, NO 51, FuCheng Road,
      HaiDian District, Beijing 100048, China. feide301@yahoo.com.cn
FAU - Li, Jiye
AU  - Li J
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - Saudi Arabia
TA  - Saudi Med J
JT  - Saudi medical journal
JID - 7909441
SB  - IM
MH  - Abdominal Wall/*surgery
MH  - Adult
MH  - Aged
MH  - Equipment Design
MH  - Female
MH  - Hernia, Abdominal/*surgery
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Reconstructive Surgical Procedures/methods
MH  - Retrospective Studies
MH  - *Surgical Mesh
EDAT- 2011/05/11 06:00
MHDA- 2011/10/14 06:00
CRDT- 2011/05/11 06:00
PHST- 2011/05/11 06:00 [entrez]
PHST- 2011/05/11 06:00 [pubmed]
PHST- 2011/10/14 06:00 [medline]
AID - 0' [pii]
PST - ppublish
SO  - Saudi Med J. 2011 May;32(5):504-9.


PMID- 21556305
OWN - NLM
STAT- MEDLINE
DCOM- 20110829
LR  - 20211020
IS  - 1564-0604 (Electronic)
IS  - 0042-9686 (Linking)
VI  - 89
IP  - 5
DP  - 2011 May 1
TI  - No-fault compensation following adverse events attributed to vaccination: a
      review of international programmes.
PG  - 371-8
LID - 10.2471/BLT.10.081901 [doi]
AB  - Programmes that provide no-fault compensation for an adverse event following
      vaccination have been implemented in 19 countries worldwide, the first in Germany
      in 1961 and the most recent in Hungary in 2005. We performed a review of these
      programmes and determined elements that were common to all of them:
      administration and funding, eligibility, process and decision-making, standard of
      proof, elements of compensation and litigation rights. Most programmes were
      administered by state or national governments except in Finland and Sweden where 
      they are coordinated by pharmaceutical manufacturers. Although funding is usually
      from Treasury, Taiwan (China) and the United States of America impose a tax on
      vaccine doses distributed. Decisions on compensation are made using established
      criteria or assessed on a case-by-case basis, while the standard of proof
      required is usually less than that required for court cases. Benefits provided by
      programmes include medical costs, disability pensions and benefits for
      noneconomic loss and death. Most countries allow claimants to seek legal damages 
      through the courts or a compensation scheme payout but not both. We conclude that
      a variety of programmes, based on ethical principles, have been successful and
      financially viable in developed countries throughout the world. We believe there 
      is a strong argument for widespread implementation of these programmes in other
      developed countries.
FAU - Looker, Clare
AU  - Looker C
AD  - Victorian Infectious Diseases Reference Laboratory, Carlton South, Vic.,
      Australia. Clare_Looker@hotmail.com
FAU - Kelly, Heath
AU  - Kelly H
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110321
PL  - Switzerland
TA  - Bull World Health Organ
JT  - Bulletin of the World Health Organization
JID - 7507052
RN  - 0 (Vaccines)
SB  - IM
MH  - Eligibility Determination
MH  - Humans
MH  - Insurance, Liability/*economics/*legislation & jurisprudence
MH  - Vaccines/*adverse effects/economics
PMC - PMC3089384
EDAT- 2011/05/11 06:00
MHDA- 2011/08/30 06:00
CRDT- 2011/05/11 06:00
PHST- 2010/08/10 00:00 [received]
PHST- 2011/02/01 00:00 [revised]
PHST- 2011/02/03 00:00 [accepted]
PHST- 2011/05/11 06:00 [entrez]
PHST- 2011/05/11 06:00 [pubmed]
PHST- 2011/08/30 06:00 [medline]
AID - 10.2471/BLT.10.081901 [doi]
PST - ppublish
SO  - Bull World Health Organ. 2011 May 1;89(5):371-8. doi: 10.2471/BLT.10.081901. Epub
      2011 Mar 21.


PMID- 21556181
OWN - NLM
STAT- MEDLINE
DCOM- 20110825
LR  - 20220317
IS  - 1660-4601 (Electronic)
IS  - 1660-4601 (Linking)
VI  - 8
IP  - 3
DP  - 2011 Mar
TI  - Subjects agree to participate in environmental health studies without fully
      comprehending the associated risk.
PG  - 830-41
LID - 10.3390/ijerph8030830 [doi]
AB  - Recent advances in environmental health research have greatly improved our
      ability to measure and quantify how individuals are exposed. These advances,
      however, bring bioethical uncertainties and potential risks that individuals
      should be aware of before consenting to participate. This study assessed how well
      participants from two environmental health studies comprehended consent form
      material. After signing the consent form, participants were asked to complete a
      comprehension assessment tool. The tool measured whether participants could
      recognize or recall six elements of the consent form they had just reviewed.
      Additional data were collected to look for differences in comprehension by
      gender, age, race, and the time spent reading the original consent form.
      Seventy-three participants completed a comprehension assessment tool. Scores
      ranged from 1.91 to 6.00 (mean = 4.66); only three people had perfect
      comprehension scores. Among the least comprehended material were questions on
      study-related risks. Overall, 53% of participants were not aware of two or more
      study-related risks. As environmental public health studies pose uncertainties
      and potential risks, researchers need to do more to assess participants'
      understanding before assuming that individuals have given their 'informed'
      consent.
FAU - Lee, Robin
AU  - Lee R
AD  - Division of Health Studies, US Agency for Toxic Substances and Disease Registry, 
      4770 Buford Highway NE, MS F-57, Atlanta, GA 30341, USA. RLee3@cdc.gov
FAU - Lampert, Samantha
AU  - Lampert S
FAU - Wilder, Lynn
AU  - Wilder L
FAU - Sowell, Anne L
AU  - Sowell AL
LA  - eng
PT  - Journal Article
DEP - 20110311
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
SB  - IM
MH  - Adult
MH  - Aged
MH  - Child
MH  - *Comprehension
MH  - *Consent Forms
MH  - *Environmental Health
MH  - Ethics, Research
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Research Subjects
MH  - Risk Assessment
MH  - Socioeconomic Factors
MH  - Young Adult
PMC - PMC3083672
OTO - NOTNLM
OT  - *bioethics
OT  - *comprehension
OT  - *consent forms
OT  - *environmental health
OT  - *ethics
OT  - *informed consent
OT  - *research subjects
EDAT- 2011/05/11 06:00
MHDA- 2011/08/27 06:00
CRDT- 2011/05/11 06:00
PHST- 2011/01/06 00:00 [received]
PHST- 2011/03/02 00:00 [revised]
PHST- 2011/03/08 00:00 [accepted]
PHST- 2011/05/11 06:00 [entrez]
PHST- 2011/05/11 06:00 [pubmed]
PHST- 2011/08/27 06:00 [medline]
AID - 10.3390/ijerph8030830 [doi]
AID - ijerph8030830 [pii]
PST - ppublish
SO  - Int J Environ Res Public Health. 2011 Mar;8(3):830-41. doi:
      10.3390/ijerph8030830. Epub 2011 Mar 11.


PMID- 21556086
OWN - NLM
STAT- MEDLINE
DCOM- 20110722
LR  - 20191210
IS  - 0807-7096 (Electronic)
IS  - 0029-2001 (Linking)
VI  - 131
IP  - 8
DP  - 2011 May 6
TI  - [Evaluation of the compulsory practice period for doctors in Norwegian
      hospitals].
PG  - 824-7
LID - 10.4045/tidsskr.10.0703 [doi]
AB  - BACKGROUND: The Norwegian Internship Council has uncovered weaknesses associated 
      with the compulsory practice period in hospitals for doctors, both on a national 
      basis and for North Trondelag County. MATERIAL AND METHODS: In 2007 and 2008, 79%
      (859) of all interns in Norwegian hospitals participated in the Council's
      national evaluation of the practice period. We compared the results from interns 
      serving at hospitals in Levanger and Namsos (North Trondelag) (n = 39) with those
      from interns serving at the other hospitals in Norway (n = 820). RESULTS: At the 
      surgical and medical departments in Levanger, the training in clinical procedures
      and acute medical conditions (simulator training) was similar or better than that
      in the other hospitals in Norway, but the guidance given to candidates in these
      departments was neither considered to be especially useful (12% and 17%) nor did 
      it focus on problems related to ethics (0-8%). In general the guidance was
      perceived as more useful and systematic in psychiatric wards than in somatic
      ones. Fewer candidates in Namsos had experience with patient rounds (69%) and
      writing of case reports (79%) than those in hospitals in the rest of the country,
      and no interns in psychiatry reported that they had received thorough training in
      cooperation with the primary health services or in psychopharmacology.
      INTERPRETATION: National data from the Internship Council conceal important
      variations between hospitals, and to be useful for local improvement work they
      have to be reanalysed. The identified weaknesses for interns in North Trondelag
      led to implementation of new routines for guidance, training in simulation and
      law before start of the practice period.
FAU - Bjerkeset, Ottar
AU  - Bjerkeset O
AD  - Forsknings- og utviklingsavdelingen (FoU), Helse Nord-Trondelag HF ogInstitutt
      for nevromedisin, Norges teknisk-naturvitenskapelige universitet, Norway.
      ottar.bjerkeset@ntnu.no
FAU - Romild, Ulla
AU  - Romild U
FAU - Haugdahl, Hege S
AU  - Haugdahl HS
FAU - Nylenna, Magne
AU  - Nylenna M
LA  - nor
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
TT  - Evaluering av turnustjenesten i sykehus.
PL  - Norway
TA  - Tidsskr Nor Laegeforen
JT  - Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny
      raekke
JID - 0413423
SB  - IM
MH  - Clinical Competence
MH  - Hospital Departments/organization & administration
MH  - Humans
MH  - *Internship and Residency/organization & administration/standards
MH  - Norway
MH  - Preceptorship
MH  - Surveys and Questionnaires
EDAT- 2011/05/11 06:00
MHDA- 2011/07/23 06:00
CRDT- 2011/05/11 06:00
PHST- 2011/05/11 06:00 [entrez]
PHST- 2011/05/11 06:00 [pubmed]
PHST- 2011/07/23 06:00 [medline]
AID - 2097588 [pii]
AID - 10.4045/tidsskr.10.0703 [doi]
PST - ppublish
SO  - Tidsskr Nor Laegeforen. 2011 May 6;131(8):824-7. doi: 10.4045/tidsskr.10.0703.


PMID- 21555942
OWN - NLM
STAT- MEDLINE
DCOM- 20120327
LR  - 20220409
IS  - 1530-0366 (Electronic)
IS  - 1098-3600 (Linking)
VI  - 13
IP  - 9
DP  - 2011 Sep
TI  - Active choice but not too active: public perspectives on biobank consent models.
PG  - 821-31
LID - 10.1097/GIM.0b013e31821d2f88 [doi]
AB  - PURPOSE: Despite important recent work, US public attitudes toward specific
      biobank consent models are not well understood. Public opinion data can help
      shape efforts to develop ethically sound and publicly trusted mechanisms for
      informing and consenting prospective biobank donors. The purpose of this study
      was to explore public perspectives toward a range of consent models currently
      being used or considered for use among comprehensive US biobanks. METHODS: The
      study used an exploratory mixed-methods design, using focus groups and telephone 
      surveys. Eligible participants were English-speaking residents in the catchment
      area of a comprehensive biobank being developed at the University of Iowa.
      RESULTS: Forty-eight participants in seven focus groups and 751 survey
      participants were recruited. Biobanks were unfamiliar to almost all study
      participants but were seen as valuable resources. Most focus group (63%) and
      survey (67%) participants preferred a prospective opt-in over an opt-out consent 
      approach. Broad, research-unspecific consent was preferred over categorical and
      study-specific consent models for purposes of approving future research use.
      CONCLUSION: Many individuals may want to make an active and informed choice at
      the point of being approached for biobank participation but are prepared to
      consent broadly to future research use and to forego additional choices as a
      result.
FAU - Simon, Christian M
AU  - Simon CM
AD  - Program in Bioethics and Humanities, Carver College of Medicine, Iowa City, Iowa 
      52242-1190, USA. christian-simon@uiowa.edu
FAU - L'heureux, Jamie
AU  - L'heureux J
FAU - Murray, Jeffrey C
AU  - Murray JC
FAU - Winokur, Patricia
AU  - Winokur P
FAU - Weiner, George
AU  - Weiner G
FAU - Newbury, Elizabeth
AU  - Newbury E
FAU - Shinkunas, Laura
AU  - Shinkunas L
FAU - Zimmerman, Bridget
AU  - Zimmerman B
LA  - eng
GR  - UL1 TR000442/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genet Med
JT  - Genetics in medicine : official journal of the American College of Medical
      Genetics
JID - 9815831
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biological Specimen Banks/*ethics
MH  - Female
MH  - Focus Groups
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Male
MH  - Mental Competency
MH  - Middle Aged
MH  - Public Opinion
MH  - United States
PMC - PMC3658114
MID - NIHMS453514
EDAT- 2011/05/11 06:00
MHDA- 2012/03/28 06:00
CRDT- 2011/05/11 06:00
PHST- 2011/05/11 06:00 [entrez]
PHST- 2011/05/11 06:00 [pubmed]
PHST- 2012/03/28 06:00 [medline]
AID - 10.1097/GIM.0b013e31821d2f88 [doi]
AID - S1098-3600(21)03646-7 [pii]
PST - ppublish
SO  - Genet Med. 2011 Sep;13(9):821-31. doi: 10.1097/GIM.0b013e31821d2f88.


PMID- 21555849
OWN - NLM
STAT- MEDLINE
DCOM- 20111130
LR  - 20110530
IS  - 1741-2552 (Electronic)
IS  - 1741-2552 (Linking)
VI  - 8
IP  - 3
DP  - 2011 Jun
TI  - Ethical guidance for the management of conflicts of interest for researchers,
      engineers and clinicians engaged in the development of therapeutic deep brain
      stimulation.
PG  - 033001
LID - 10.1088/1741-2560/8/3/033001 [doi]
AB  - The clinical promise of deep brain stimulation (DBS) for neuropsychiatric
      conditions is coupled with the potential for ethical conflicts of interest
      because the work is so heavily reliant upon collaborations between academia,
      industry and the clinic. To foster transparency and public trust, we offer
      ethical guidance for the management of conflicts of interest in the conduct of
      DBS research and practice so that this nascent field can better balance competing
      goods and engineer new and better strategies for the amelioration of human
      suffering. We also hope that our ethical analysis will be of relevance to those
      working with other related neuroprosthetic devices, such brain-computer
      interfaces and neural arrays, which naturally share many of the same concerns.
FAU - Fins, Joseph J
AU  - Fins JJ
AD  - Division of Medical Ethics, New York Presbyterian-Weill Cornell Medical Center,
      435 East 70th Street, Suite 4-J, New York, NY 10021, USA. jjfins@med.cornell.edu
FAU - Schlaepfer, Thomas E
AU  - Schlaepfer TE
FAU - Nuttin, Bart
AU  - Nuttin B
FAU - Kubu, Cynthia S
AU  - Kubu CS
FAU - Galert, Thorsten
AU  - Galert T
FAU - Sturm, Volker
AU  - Sturm V
FAU - Merkel, Reinhard
AU  - Merkel R
FAU - Mayberg, Helen S
AU  - Mayberg HS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110510
PL  - England
TA  - J Neural Eng
JT  - Journal of neural engineering
JID - 101217933
SB  - IM
MH  - Biomedical Engineering/*ethics
MH  - Biomedical Research/*ethics
MH  - *Conflict of Interest
MH  - Deep Brain Stimulation/*ethics
MH  - Humans
MH  - Internationality
MH  - Medical Staff/*ethics
EDAT- 2011/05/11 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/05/11 06:00
PHST- 2011/05/11 06:00 [entrez]
PHST- 2011/05/11 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S1741-2560(11)82782-5 [pii]
AID - 10.1088/1741-2560/8/3/033001 [doi]
PST - ppublish
SO  - J Neural Eng. 2011 Jun;8(3):033001. doi: 10.1088/1741-2560/8/3/033001. Epub 2011 
      May 10.


PMID- 21555753
OWN - NLM
STAT- MEDLINE
DCOM- 20110908
LR  - 20211020
IS  - 1544-1717 (Electronic)
IS  - 1544-1709 (Linking)
VI  - 9
IP  - 3
DP  - 2011 May-Jun
TI  - Preventing life-sustaining treatment by default.
PG  - 250-6
LID - 10.1370/afm.1227 [doi]
AB  - Many physicians will at some point care for patients who will receive
      life-sustaining treatment by default, because there are no instructions available
      from the patient as to what kind of care is preferred, and because surrogates are
      likely to ask for everything to be done when they do not know a patient's
      preferences. We use the methods of ethics informed by qualitative focus group
      research to identify 5 pathways to life-sustaining treatment by default
      originating with the patient's preferred decision-making style: deciding for
      oneself or letting others decide. We emphasize preventing the ethically unwelcome
      outcome of life-sustaining treatment by default by increasing the frequency with 
      which patients make clear decisions or clearly express their values and goals
      that they then communicate to physicians or surrogates.
FAU - Braun, Ursula K
AU  - Braun UK
AD  - Health Services Research and Development Center of Excellence, Michael E. DeBakey
      VA Medical Center, Houston, Texas, USA. ubraun@bcm.edu
FAU - McCullough, Laurence B
AU  - McCullough LB
LA  - eng
GR  - 1 K01 HP00074/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Ann Fam Med
JT  - Annals of family medicine
JID - 101167762
SB  - IM
MH  - Advance Directives/*ethics
MH  - Euthanasia, Passive/*ethics
MH  - Focus Groups
MH  - Humans
MH  - Life Support Care/*ethics
MH  - Patient Satisfaction
MH  - *Personal Autonomy
MH  - Physician-Patient Relations/*ethics
MH  - Qualitative Research
MH  - Terminal Care/*ethics
PMC - PMC3090434
EDAT- 2011/05/11 06:00
MHDA- 2011/09/09 06:00
CRDT- 2011/05/11 06:00
PHST- 2011/05/11 06:00 [entrez]
PHST- 2011/05/11 06:00 [pubmed]
PHST- 2011/09/09 06:00 [medline]
AID - 9/3/250 [pii]
AID - 10.1370/afm.1227 [doi]
PST - ppublish
SO  - Ann Fam Med. 2011 May-Jun;9(3):250-6. doi: 10.1370/afm.1227.


PMID- 21555586
OWN - NLM
STAT- MEDLINE
DCOM- 20111007
LR  - 20220408
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 108
IP  - 21
DP  - 2011 May 24
TI  - Generation of keratinocytes from normal and recessive dystrophic epidermolysis
      bullosa-induced pluripotent stem cells.
PG  - 8797-802
LID - 10.1073/pnas.1100332108 [doi]
AB  - Embryonic stem cells (ESCs) have an unlimited proliferative capacity and
      extensive differentiation capability. They are an alternative source for
      regenerative therapies with a potential role in the treatment of several human
      diseases. The clinical use of ESCs, however, has significant ethical and
      biological obstacles related to their derivation from embryos and potential for
      immunological rejection, respectively. These disadvantages can be circumvented by
      the alternative use of induced pluripotent stem cells (iPSCs), which are
      generated from an individual's (autologous) somatic cells by exogenous expression
      of defined transcription factors and have biological characteristics similar to
      ESCs. In recent years, patient-specific iPSCs have been generated to study
      disease mechanisms and develop iPSC-based therapies. The development of
      iPSC-based therapies for skin diseases requires successful differentiation of
      iPSCs into cellular components of the skin, including epidermal keratinocytes.
      Here, we succeeded in generating iPSCs not only from normal human fibroblasts but
      also from fibroblasts isolated from the skin of two patients with recessive
      dystrophic epidermolysis bullosa. Moreover, we differentiated both of these iPSCs
      into keratinocytes with high efficiency, and generated 3D skin equivalents using 
      iPSC-derived keratinocytes, suggesting that they were fully functional. Our
      studies indicate that autologous iPSCs have the potential to provide a source of 
      cells for regenerative therapies for specific skin diseases.
FAU - Itoh, Munenari
AU  - Itoh M
AD  - Departments of Dermatology, Columbia University, New York, NY 10032, USA.
FAU - Kiuru, Maija
AU  - Kiuru M
FAU - Cairo, Mitchell S
AU  - Cairo MS
FAU - Christiano, Angela M
AU  - Christiano AM
LA  - eng
GR  - P30 AR044535/AR/NIAMS NIH HHS/United States
GR  - P30AR044535/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110509
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
SB  - IM
MH  - Cell Culture Techniques/methods
MH  - Cell Differentiation
MH  - Epidermolysis Bullosa Dystrophica/*pathology
MH  - Fibroblasts/cytology
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*cytology
MH  - Keratinocytes/*cytology
MH  - Regenerative Medicine/*methods
MH  - Skin Diseases/therapy
PMC - PMC3102348
EDAT- 2011/05/11 06:00
MHDA- 2011/10/08 06:00
CRDT- 2011/05/11 06:00
PHST- 2011/05/11 06:00 [entrez]
PHST- 2011/05/11 06:00 [pubmed]
PHST- 2011/10/08 06:00 [medline]
AID - 1100332108 [pii]
AID - 10.1073/pnas.1100332108 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2011 May 24;108(21):8797-802. doi:
      10.1073/pnas.1100332108. Epub 2011 May 9.


PMID- 21555352
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20181201
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 260
IP  - 2
DP  - 2011 Aug
TI  - Dynamic microbubble contrast-enhanced US to measure tumor response to targeted
      therapy: a proposed clinical protocol with results from renal cell carcinoma
      patients receiving antiangiogenic therapy.
PG  - 581-90
LID - 10.1148/radiol.11101893 [doi]
AB  - PURPOSE: To develop and implement an evidence-based protocol for characterizing
      vascular response of renal cell carcinoma (RCC) to targeted therapy by using
      dynamic contrast material-enhanced (DCE) ultrasonography (US). MATERIALS AND
      METHODS: The study was approved by the institutional research ethics board;
      written informed consent was obtained from all patients. Seventeen patients (four
      women; median age, 58 years; range, 42-72 years; 13 men, median age, 62 years;
      range, 45-81 years) with metastatic RCC were examined by using DCE US before and 
      after 2 weeks of treatment with sunitinib (May 2007 to October 2009). Two
      contrast agent techniques--bolus injection and disruption-replenishment infusion 
      of microbubbles--were compared. Changes in tumor blood velocity and fractional
      blood volume were measured with both methods, together with reproducibility and
      effect of compensation for respiratory motion. Tumor changes were assessed with
      computed tomography, by using the best response with the Response Evaluation
      Criteria in Solid Tumors (RECIST) and progression-free survival (PFS). Follow-up 
      RECIST measurements were performed at 6-week intervals until progressive disease 
      was detected. RESULTS: In response to treatment, median tumor fractional blood
      volume measured with the disruption-replenishment infusion method decreased by
      73.2% (interquartile range, 46%-87%) (P < .002), with repeated-measure
      reproducibility of 9%-15%. Significant decreases were also seen with the bolus
      method, but with poor correlation of changes in bolus peak (r = 0.46, P = .066)
      and area under the curve (r = 0.47, P = .058), compared with infusion
      measurements. Changes in DCE US parameters over 2 weeks did not correlate with
      PFS and could not be used to predict long-term assessment of best response by
      using RECIST. Follow-up times ranged 28-501 days; the median was 164 days.
      CONCLUSION: DCE US provides reproducible and sensitive assessment of vascular
      changes in response to antiangiogenic therapy. The disruption-replenishment
      infusion protocol is a flexible method suitable for many tumor types, but further
      studies are needed to assess whether this protocol may be predictive of patient
      outcome.
CI  - (c) RSNA, 2011.
FAU - Williams, Ross
AU  - Williams R
AD  - Imaging Research, Sunnybrook Health Sciences Centre, University of Toronto, 2075 
      Bayview Ave, Room S6-39, Toronto, ON, Canada M4N 3M5. williams@sri.utoronto.ca
FAU - Hudson, John M
AU  - Hudson JM
FAU - Lloyd, Brendan A
AU  - Lloyd BA
FAU - Sureshkumar, Ahthavan R
AU  - Sureshkumar AR
FAU - Lueck, Gordon
AU  - Lueck G
FAU - Milot, Laurent
AU  - Milot L
FAU - Atri, Mostafa
AU  - Atri M
FAU - Bjarnason, Georg A
AU  - Bjarnason GA
FAU - Burns, Peter N
AU  - Burns PN
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110509
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Angiogenesis Inhibitors)
RN  - 0 (Contrast Media)
RN  - 0 (Definity)
RN  - 0 (Fluorocarbons)
RN  - 0 (Indoles)
RN  - 0 (Pyrroles)
RN  - V99T50803M (Sunitinib)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Angiogenesis Inhibitors/*therapeutic use
MH  - Area Under Curve
MH  - Carcinoma, Renal Cell/*diagnostic imaging/*drug therapy/pathology
MH  - *Contrast Media
MH  - Evidence-Based Medicine
MH  - Female
MH  - *Fluorocarbons
MH  - Humans
MH  - Indoles/*therapeutic use
MH  - Kidney Neoplasms/*diagnostic imaging/*drug therapy/pathology
MH  - Male
MH  - Microbubbles
MH  - Middle Aged
MH  - Neoplasm Metastasis
MH  - Pyrroles/*therapeutic use
MH  - Reproducibility of Results
MH  - Statistics, Nonparametric
MH  - Sunitinib
MH  - Survival Analysis
MH  - Tomography, X-Ray Computed
MH  - Ultrasonography
EDAT- 2011/05/11 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/05/11 06:00
PHST- 2011/05/11 06:00 [entrez]
PHST- 2011/05/11 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - radiol.11101893 [pii]
AID - 10.1148/radiol.11101893 [doi]
PST - ppublish
SO  - Radiology. 2011 Aug;260(2):581-90. doi: 10.1148/radiol.11101893. Epub 2011 May 9.


PMID- 21555351
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 260
IP  - 2
DP  - 2011 Aug
TI  - Distal ureteral calculi: US follow-up.
PG  - 575-80
LID - 10.1148/radiol.11101077 [doi]
AB  - PURPOSE: To assess accuracy of ultrasonographic (US) follow-up of distal ureteral
      calculi by using computed tomography (CT) and conventional radiography (kidneys, 
      ureters, and bladder) as reference standards. MATERIALS AND METHODS: The study
      was approved by the Regional Ethics Committee, and written informed consent was
      obtained. One hundred fifty-eight patients with CT-diagnosed symptomatic ureteral
      calculi, for whom follow-up imaging was ordered, were enrolled from February 2006
      to December 2008. Six were excluded, having not met study entry criteria, with
      121 men (mean age, 49 years; range, 20-91 years) and 31 women (mean age, 44
      years; range, 34-77 years) completing the protocol with adequate reference
      standard imaging. Targeted transabdominal US occurred coincidently with follow-up
      CT (n = 92) or radiography (n = 60), with US evaluation prospectively compared
      considering sensitivity and specificity. Statistical analysis was performed with 
      a chi(2) test, t test, or paired t test, as appropriate. RESULTS: Results of nine
      US examinations were nondiagnostic because of inadequate ureteral visualization, 
      and among these, two cases showed residual distal calculi. Of the remaining 143
      patients, 33 had residual distal calculi, all visualized with US. There was a
      single false-positive study, giving sensitivity, including nondiagnostic US
      examinations, of 94.3% (95% confidence interval [CI]: 80.8%, 99.3%) and
      specificity of 99.1% (95% CI: 95.3%, 100%). All calculi appeared hyperechoic with
      posterior acoustic shadowing. Additional diagnostic features included presence of
      a hypoechoic rim and Doppler twinkle artifact. Mean stone length was 7.2 mm +/-
      2.6 (standard deviation) (range, 4-18 mm). Mean ureteral length visualized was
      36.4 mm (range, 12-77 mm), with calculi positioned at a mean of 13.1 mm +/- 11.2 
      (range, 0-40 mm) from the ureterovesical junction (UVJ). Nondiagnostic results
      were more likely with bladder volume of 110 mL or less (eight [16%] of 50 vs one 
      [1%] of 102, P = .0009). CONCLUSION: Ureteral calculi within 35 mm of the UVJ can
      be accurately followed-up by using transabdominal US, which substantially reduces
      patient radiation burden.
CI  - (c) RSNA, 2011.
FAU - Moesbergen, Todd C
AU  - Moesbergen TC
AD  - Department of Radiology, Christchurch Hospital, 2 Riccarton Ave, Christchurch,
      Canterbury 8011, New Zealand. tmoesbergen@hotmail.com
FAU - de Ryke, Rex J
AU  - de Ryke RJ
FAU - Dunbar, Sally
AU  - Dunbar S
FAU - Wells, J Elisabeth
AU  - Wells JE
FAU - Anderson, Nigel G
AU  - Anderson NG
LA  - eng
PT  - Journal Article
DEP - 20110509
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Artifacts
MH  - Chi-Square Distribution
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Sensitivity and Specificity
MH  - Tomography, X-Ray Computed
MH  - Ultrasonography
MH  - Ureteral Calculi/*diagnostic imaging
EDAT- 2011/05/11 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/05/11 06:00
PHST- 2011/05/11 06:00 [entrez]
PHST- 2011/05/11 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - radiol.11101077 [pii]
AID - 10.1148/radiol.11101077 [doi]
PST - ppublish
SO  - Radiology. 2011 Aug;260(2):575-80. doi: 10.1148/radiol.11101077. Epub 2011 May 9.


PMID- 21553952
OWN - NLM
STAT- MEDLINE
DCOM- 20110912
LR  - 20220317
IS  - 1935-990X (Electronic)
IS  - 0003-066X (Linking)
VI  - 66
IP  - 4
DP  - 2011 May-Jun
TI  - The psychological impacts of global climate change.
PG  - 265-76
LID - 10.1037/a0023141 [doi]
AB  - An appreciation of the psychological impacts of global climate change entails
      recognizing the complexity and multiple meanings associated with climate change; 
      situating impacts within other social, technological, and ecological transitions;
      and recognizing mediators and moderators of impacts. This article describes three
      classes of psychological impacts: direct (e.g., acute or traumatic effects of
      extreme weather events and a changed environment); indirect (e.g., threats to
      emotional well-being based on observation of impacts and concern or uncertainty
      about future risks); and psychosocial (e.g., chronic social and community effects
      of heat, drought, migrations, and climate-related conflicts, and postdisaster
      adjustment). Responses include providing psychological interventions in the wake 
      of acute impacts and reducing the vulnerabilities contributing to their severity;
      promoting emotional resiliency and empowerment in the context of indirect
      impacts; and acting at systems and policy levels to address broad psychosocial
      impacts. The challenge of climate change calls for increased ecological literacy,
      a widened ethical responsibility, investigations into a range of psychological
      and social adaptations, and an allocation of resources and training to improve
      psychologists' competency in addressing climate change-related impacts.
FAU - Doherty, Thomas J
AU  - Doherty TJ
AD  - Department of Counseling Psychology, Lewis & Clark Graduate School of Education
      and Counseling, Portland, OR 97208-3174, USA. thomas@selfsustain.com
FAU - Clayton, Susan
AU  - Clayton S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am Psychol
JT  - The American psychologist
JID - 0370521
SB  - IM
MH  - Adaptation, Psychological
MH  - *Climate Change
MH  - *Disasters
MH  - *Environment
MH  - Humans
EDAT- 2011/05/11 06:00
MHDA- 2011/09/13 06:00
CRDT- 2011/05/11 06:00
PHST- 2011/05/11 06:00 [entrez]
PHST- 2011/05/11 06:00 [pubmed]
PHST- 2011/09/13 06:00 [medline]
AID - 2011-09485-003 [pii]
AID - 10.1037/a0023141 [doi]
PST - ppublish
SO  - Am Psychol. 2011 May-Jun;66(4):265-76. doi: 10.1037/a0023141.


PMID- 21553951
OWN - NLM
STAT- MEDLINE
DCOM- 20110912
LR  - 20110510
IS  - 1935-990X (Electronic)
IS  - 0003-066X (Linking)
VI  - 66
IP  - 4
DP  - 2011 May-Jun
TI  - Human behavioral contributions to climate change: psychological and contextual
      drivers.
PG  - 251-64
LID - 10.1037/a0023472 [doi]
AB  - We are facing rapid changes in the global climate, and these changes are
      attributable to human behavior. Humans produce this global impact through our use
      of natural resources, multiplied by the vast increase in population seen in the
      past 50 to 100 years. Our goal in this article is to examine the underlying
      psychosocial causes of human impact, primarily through patterns of reproduction
      and consumption. We identify and distinguish individual, societal, and behavioral
      predictors of environmental impact. Relevant research in these areas (as well as 
      areas that would be aided by greater attention by psychologists) are reviewed. We
      conclude by highlighting ethical issues that emerge when considering how to
      address human behavioral contributions to climate change.
FAU - Swim, Janet K
AU  - Swim JK
AD  - Department of Psychology, Pennsylvania State University, University Park,
      Pennsylvania 16802-3106, USA. jks4@psu.edu
FAU - Clayton, Susan
AU  - Clayton S
FAU - Howard, George S
AU  - Howard GS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am Psychol
JT  - The American psychologist
JID - 0370521
SB  - IM
MH  - *Behavior
MH  - Climate
MH  - *Climate Change
MH  - *Conservation of Natural Resources
MH  - Culture
MH  - *Environment
MH  - Humans
MH  - Population
EDAT- 2011/05/11 06:00
MHDA- 2011/09/13 06:00
CRDT- 2011/05/11 06:00
PHST- 2011/05/11 06:00 [entrez]
PHST- 2011/05/11 06:00 [pubmed]
PHST- 2011/09/13 06:00 [medline]
AID - 2011-09485-002 [pii]
AID - 10.1037/a0023472 [doi]
PST - ppublish
SO  - Am Psychol. 2011 May-Jun;66(4):251-64. doi: 10.1037/a0023472.


PMID- 21553950
OWN - NLM
STAT- MEDLINE
DCOM- 20110912
LR  - 20110510
IS  - 1935-990X (Electronic)
IS  - 0003-066X (Linking)
VI  - 66
IP  - 4
DP  - 2011 May-Jun
TI  - Psychology's contributions to understanding and addressing global climate change.
PG  - 241-50
LID - 10.1037/a0023220 [doi]
AB  - Global climate change poses one of the greatest challenges facing humanity in
      this century. This article, which introduces the American Psychologist special
      issue on global climate change, follows from the report of the American
      Psychological Association Task Force on the Interface Between Psychology and
      Global Climate Change. In this article, we place psychological dimensions of
      climate change within the broader context of human dimensions of climate change
      by addressing (a) human causes of, consequences of, and responses (adaptation and
      mitigation) to climate change and (b) the links between these aspects of climate 
      change and cognitive, affective, motivational, interpersonal, and organizational 
      responses and processes. Characteristics of psychology that cross content domains
      and that make the field well suited for providing an understanding of climate
      change and addressing its challenges are highlighted. We also consider ethical
      imperatives for psychologists' involvement and provide suggestions for ways to
      increase psychologists' contribution to the science of climate change.
FAU - Swim, Janet K
AU  - Swim JK
AD  - Department of Psychology, Pennsylvania State University, University Park, PA
      16802-3106, USA. jks4@psu.edu
FAU - Stern, Paul C
AU  - Stern PC
FAU - Doherty, Thomas J
AU  - Doherty TJ
FAU - Clayton, Susan
AU  - Clayton S
FAU - Reser, Joseph P
AU  - Reser JP
FAU - Weber, Elke U
AU  - Weber EU
FAU - Gifford, Robert
AU  - Gifford R
FAU - Howard, George S
AU  - Howard GS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am Psychol
JT  - The American psychologist
JID - 0370521
SB  - IM
MH  - *Climate Change
MH  - Environment
MH  - Humans
MH  - Interdisciplinary Studies
MH  - *Psychology
MH  - *Science
EDAT- 2011/05/11 06:00
MHDA- 2011/09/13 06:00
CRDT- 2011/05/11 06:00
PHST- 2011/05/11 06:00 [entrez]
PHST- 2011/05/11 06:00 [pubmed]
PHST- 2011/09/13 06:00 [medline]
AID - 2011-09485-001 [pii]
AID - 10.1037/a0023220 [doi]
PST - ppublish
SO  - Am Psychol. 2011 May-Jun;66(4):241-50. doi: 10.1037/a0023220.


PMID- 21553641
OWN - NLM
STAT- MEDLINE
DCOM- 20110526
LR  - 20170214
IS  - 0306-3127 (Print)
IS  - 0306-3127 (Linking)
VI  - 41
IP  - 1
DP  - 2011 Feb
TI  - Matters of care in technoscience: assembling neglected things. .
PG  - 85-106
AB  - This paper aims to encourage an ethos of care in the study of science and
      technology. It starts with a reading of Bruno Latour's notion of'matters of
      concern' as favouring an awareness of the ethico-political effects of
      constructivist accounts in STS. Introducing attention to concern brings us closer
      to a notion of care. However, there is a'critical' edge to care that Latour's
      politics of things tends to disregard. Drawing upon feminist knowledge politics, 
      I propose to treat matters of fact and sociotechnical assemblages as 'matters of 
      care' and argue that engaging with care requires a speculative commitment to
      neglected things.
FAU - de la Bellacasa, Maria Puig
AU  - de la Bellacasa MP
AD  - School of Management, University of Leicester, Ken Edwards Building, Leicester
      LEI 7RH, UK. m.puig@le.ac.uk
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Soc Stud Sci
JT  - Social studies of science
JID - 7506743
MH  - Ethics
MH  - Feminism
MH  - Humans
MH  - *Science
MH  - Sociology
MH  - *Technology
EDAT- 2011/05/11 06:00
MHDA- 2011/05/27 06:00
CRDT- 2011/05/11 06:00
PHST- 2011/05/11 06:00 [entrez]
PHST- 2011/05/11 06:00 [pubmed]
PHST- 2011/05/27 06:00 [medline]
AID - 10.1177/0306312710380301 [doi]
PST - ppublish
SO  - Soc Stud Sci. 2011 Feb;41(1):85-106. doi: 10.1177/0306312710380301.


PMID- 21553578
OWN - NLM
STAT- MEDLINE
DCOM- 20110607
LR  - 20191027
IS  - 0037-8046 (Print)
IS  - 0037-8046 (Linking)
VI  - 56
IP  - 2
DP  - 2011 Apr
TI  - Using spiritual interventions in practice: developing some guidelines from
      evidence-based practice.
PG  - 149-58
AB  - Research indicates that many social work practitioners are interested in using
      spiritual interventions in clinical settings. Unfortunately, studies also
      indicate that practitioners have frequently received minimal training on the
      topic during their graduate education. Drawing from the evidence-based practice
      movement, this article develops some guidelines to assist practitioners in using 
      spiritual interventions in an ethical, professional manner that fosters client
      well-being. These guidelines can be summarized under the following four rubrics: 
      (1) client preference, (2) evaluation of relevant research, (3) clinical
      expertise, and (4) cultural competency. The article concludes by emphasizing that
      these overlapping guidelines should be considered concurrently, in a manner that 
      privileges clients' needs and desires in the decision-making process.
FAU - Hodge, David R
AU  - Hodge DR
AD  - School of Social Work, Arizona State University, Phoenix 85004-0689, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Soc Work
JT  - Social work
JID - 2984852R
SB  - IM
MH  - Clinical Competence
MH  - Evidence-Based Practice
MH  - Humans
MH  - Professional-Patient Relations
MH  - Social Work/*methods
MH  - *Spiritual Therapies/education/methods
MH  - Spirituality
EDAT- 2011/05/11 06:00
MHDA- 2011/06/08 06:00
CRDT- 2011/05/11 06:00
PHST- 2011/05/11 06:00 [entrez]
PHST- 2011/05/11 06:00 [pubmed]
PHST- 2011/06/08 06:00 [medline]
AID - 10.1093/sw/56.2.149 [doi]
PST - ppublish
SO  - Soc Work. 2011 Apr;56(2):149-58. doi: 10.1093/sw/56.2.149.


PMID- 21553575
OWN - NLM
STAT- MEDLINE
DCOM- 20110607
LR  - 20191027
IS  - 0037-8046 (Print)
IS  - 0037-8046 (Linking)
VI  - 56
IP  - 2
DP  - 2011 Apr
TI  - Self-determination, the right to die, and culture: a literature review.
PG  - 119-28
AB  - Self-determination is a primary ethical principle underlying social work practice
      in health care settings. Since the 1970s, a right-to-die movement that shares the
      social work commitment to self-determination has grown and influences end-of-life
      care decisions. However, the role of culture is notably absent in discussions of 
      the right to die. A literature review was conducted to explore self-determination
      and the role of culture in the context of the history of the right-to-die
      movement. A total of 54 articles met the criteria for inclusion in the review. Of
      the total, 21 related to self-determination, and 12 related to ethnicity and
      culture at the end of life. A history based on the review of the right-to-die
      movement is presented. The review found that social workers support passively
      hastening death and that views of self-determination are affected by both law and
      culture. In response, social workers will face three tasks: (1) becoming more
      public in their support for client self-determination as an important standard in
      end-of-life care, (2) being more explicit in support of diverse cultural
      traditions in end-of-life decision making, and (3) expanding their traditional
      educational and bridging roles between families and medical personnel.
FAU - McCormick, Andrew J
AU  - McCormick AJ
AD  - Harborview Medical Center, University of Washington, Seattle, WA 98104, USA.
      andymcc@u.washington.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Soc Work
JT  - Social work
JID - 2984852R
SB  - IM
MH  - Attitude of Health Personnel
MH  - *Attitude to Death
MH  - Choice Behavior
MH  - Culture
MH  - Euthanasia, Active/legislation & jurisprudence/psychology
MH  - Humans
MH  - Palliative Care/psychology
MH  - *Personal Autonomy
MH  - *Right to Die/legislation & jurisprudence
MH  - Social Work
MH  - Supreme Court Decisions
MH  - United States
EDAT- 2011/05/11 06:00
MHDA- 2011/06/08 06:00
CRDT- 2011/05/11 06:00
PHST- 2011/05/11 06:00 [entrez]
PHST- 2011/05/11 06:00 [pubmed]
PHST- 2011/06/08 06:00 [medline]
AID - 10.1093/sw/56.2.119 [doi]
PST - ppublish
SO  - Soc Work. 2011 Apr;56(2):119-28. doi: 10.1093/sw/56.2.119.


PMID- 21553151
OWN - NLM
STAT- MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1573-076X (Electronic)
IS  - 0165-005X (Linking)
VI  - 35
IP  - 2
DP  - 2011 Jun
TI  - The ethical self-fashioning of physicians and health care systems in culturally
      appropriate health care.
PG  - 236-61
LID - 10.1007/s11013-011-9215-1 [doi]
AB  - Diverse advocacy groups have pushed for the recognition of cultural differences
      in health care as a means to redress inequalities in the U.S., elaborating a form
      of biocitizenship that draws on evidence of racial and ethnic health disparities 
      to make claims on both the state and health care providers. These efforts led to 
      federal regulations developed by the U.S. Office of Minority Health requiring
      health care organizations to provide Culturally and Linguistically Appropriate
      Services. Based on ethnographic research at workshops and conferences, in-depth
      interviews with cultural competence trainers, and an analysis of postings to a
      moderated listserv with 2,000 members, we explore cultural competence trainings
      as a new type of social technology in which health care providers and
      institutions are urged to engage in ethical self-fashioning to eliminate
      prejudice and embody the values of cultural relativism. Health care providers are
      called on to re-orient their practice (such as habits of gaze, touch, and
      decision-making) and to act on their own subjectivities to develop an orientation
      toward Others that is "culturally competent." We explore the diverse methods that
      cultural competence trainings use to foster a health care provider's ability to
      be self-reflexive, including face-to-face workshops and classes and self-guided
      on-line modules. We argue that the hybrid formation of culturally appropriate
      health care is becoming detached from its social justice origins as it becomes
      rationalized by and more firmly embedded in the operations of the health care
      marketplace.
FAU - Shaw, Susan J
AU  - Shaw SJ
AD  - School of Anthropology, University of Arizona, P.O. Box 210030, Tucson, AZ
      85721-0030, USA. shaws@email.arizona.edu
FAU - Armin, Julie
AU  - Armin J
LA  - eng
GR  - L60 MD000914/MD/NIMHD NIH HHS/United States
GR  - R03 HS014086/HS/AHRQ HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Cult Med Psychiatry
JT  - Culture, medicine and psychiatry
JID - 7707467
SB  - IM
MH  - Anthropology, Cultural/*education/ethics
MH  - Cultural Competency/*ethics
MH  - Curriculum
MH  - Delivery of Health Care/ethics
MH  - Education/ethics
MH  - Education, Medical/*ethics
MH  - Education, Medical, Continuing/ethics
MH  - Ethics, Medical/education
MH  - Healthcare Disparities/*ethics
MH  - Humans
MH  - Marketing of Health Services/ethics
MH  - Morals
MH  - Physician's Role
MH  - Prejudice
MH  - Social Justice/ethics
MH  - United States
PMC - PMC6360944
MID - NIHMS798905
EDAT- 2011/05/10 06:00
MHDA- 2011/11/11 06:00
CRDT- 2011/05/10 06:00
PHST- 2011/05/10 06:00 [entrez]
PHST- 2011/05/10 06:00 [pubmed]
PHST- 2011/11/11 06:00 [medline]
AID - 10.1007/s11013-011-9215-1 [doi]
PST - ppublish
SO  - Cult Med Psychiatry. 2011 Jun;35(2):236-61. doi: 10.1007/s11013-011-9215-1.


PMID- 21552759
OWN - NLM
STAT- MEDLINE
DCOM- 20111107
LR  - 20190606
IS  - 1518-8787 (Electronic)
IS  - 0034-8910 (Linking)
VI  - 45
IP  - 3
DP  - 2011 Jun
TI  - The role of plausibility in the evaluation of scientific research.
PG  - 617-20
LID - S0034-89102011000300021 [pii]
AB  - The paper discusses the impact of plausibility (the a priori probability) on the 
      results of scientific research, according to the approach proposed by Ioannidis, 
      concerning the percentage of null hypotheses erroneously classified as "positive"
      (statistically significant). The question "what fraction of positive results are 
      true-positives?", which is equivalent to the positive predictive value, is
      dependent on the combination of true and false hypotheses within a given area.
      For example, consider an area in which 90% of hypotheses are false and alpha =
      0.05 and power = 0.8: for every 1,000 hypotheses, 45 (900 x 0.05) are
      false-positives and 80 (100 x 0.8) are true-positives. Therefore, the probability
      of a positive result being a false-positive is 45/125. In addition, the reporting
      of negative results as if they were positive would contribute towards an increase
      in this fraction. Although this analysis is difficult to quantify, and these
      results are likely be overestimated, it has two implications: i) plausibility
      should be considered in the analysis of the ethical adequacy of a research
      proposal, and ii) mechanisms aimed at registering studies and protocols should be
      encouraged.
FAU - Almeida, Renan M V R
AU  - Almeida RM
AD  - Programa de Engenharia Biomedica, Universidade Federal do Rio de Janeiro, Rio de 
      Janeiro, RJ, Brasil. renan.m.v.r.almeida@gmail.com
LA  - eng
LA  - por
PT  - Journal Article
PL  - Brazil
TA  - Rev Saude Publica
JT  - Revista de saude publica
JID - 0135043
SB  - IM
MH  - *Biomedical Research
MH  - *Data Interpretation, Statistical
MH  - Humans
MH  - Models, Statistical
MH  - *Probability
MH  - Reproducibility of Results
MH  - Research Design
EDAT- 2011/05/10 06:00
MHDA- 2011/11/08 06:00
CRDT- 2011/05/10 06:00
PHST- 2010/07/14 00:00 [received]
PHST- 2010/11/14 00:00 [accepted]
PHST- 2011/05/10 06:00 [entrez]
PHST- 2011/05/10 06:00 [pubmed]
PHST- 2011/11/08 06:00 [medline]
AID - S0034-89102011000300021 [pii]
AID - 10.1590/s0034-89102011000300021 [doi]
PST - ppublish
SO  - Rev Saude Publica. 2011 Jun;45(3):617-20. doi: 10.1590/s0034-89102011000300021.


PMID- 21551464
OWN - NLM
STAT- MEDLINE
DCOM- 20120224
LR  - 20211020
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 9
DP  - 2011 Sep
TI  - Two concepts of therapeutic optimism.
PG  - 563-6
LID - 10.1136/jme.2010.038943 [doi]
AB  - Researchers and ethicists have long been concerned about the expectations for
      direct medical benefit expressed by participants in early phase clinical trials. 
      Early work on the issue considered the possibility that participants
      misunderstand the purpose of clinical research or that they are misinformed about
      the prospects for medical benefit from these trials. Recently, however, attention
      has turned to the possibility that research participants are simply expressing
      optimism or hope about their participation in these trials. The ethical
      significance of this therapeutic optimism remains unclear. This paper argues that
      there are two distinct phenomena that can be associated with the term
      'therapeutic optimism'-one is ethically benign and the other is potentially
      worrisome. Distinguishing these two phenomena is crucial for understanding the
      nature and ethical significance of therapeutic optimism. The failure to draw a
      distinction between these phenomena also helps to explain why different writers
      on the topic often speak past one another.
FAU - Jansen, Lynn A
AU  - Jansen LA
AD  - Center for Ethics in Health Care, Oregon Health and Science University, 3181 SW, 
      Sam Jackson Park, RD (UHN-86) Portland, OR 97239, USA. ljhomes@aol.com
LA  - eng
GR  - R21 CA131601/CA/NCI NIH HHS/United States
GR  - R21 CA131601-01A1/CA/NCI NIH HHS/United States
GR  - R21CA131601-01A1/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110507
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Attitude to Health
MH  - Biomedical Research/*ethics
MH  - Clinical Trials as Topic/psychology
MH  - Comprehension/drug effects
MH  - Ethics, Medical
MH  - Humans
MH  - Informed Consent/ethics/*psychology
MH  - Therapeutic Misconception/*ethics
PMC - PMC3159718
MID - NIHMS309761
EDAT- 2011/05/10 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/05/10 06:00
PHST- 2011/05/10 06:00 [entrez]
PHST- 2011/05/10 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - jme.2010.038943 [pii]
AID - 10.1136/jme.2010.038943 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Sep;37(9):563-6. doi: 10.1136/jme.2010.038943. Epub 2011 May
      7.


PMID- 21551385
OWN - NLM
STAT- MEDLINE
DCOM- 20120117
LR  - 20220331
IS  - 1541-0048 (Electronic)
IS  - 0090-0036 (Linking)
VI  - 101 Suppl 1
DP  - 2011 Dec
TI  - Health disparities and health equity: the issue is justice.
PG  - S149-55
LID - 10.2105/AJPH.2010.300062 [doi]
AB  - Eliminating health disparities is a Healthy People goal. Given the diverse and
      sometimes broad definitions of health disparities commonly used, a subcommittee
      convened by the Secretary's Advisory Committee for Healthy People 2020 proposed
      an operational definition for use in developing objectives and targets,
      determining resource allocation priorities, and assessing progress. Based on that
      subcommittee's work, we propose that health disparities are systematic, plausibly
      avoidable health differences adversely affecting socially disadvantaged groups;
      they may reflect social disadvantage, but causality need not be established. This
      definition, grounded in ethical and human rights principles, focuses on the
      subset of health differences reflecting social injustice, distinguishing health
      disparities from other health differences also warranting concerted attention,
      and from health differences in general. We explain the definition, its underlying
      concepts, the challenges it addresses, and the rationale for applying it to
      United States public health policy.
FAU - Braveman, Paula A
AU  - Braveman PA
AD  - University of California, San Francisco, CA 94118, USA. Braveman@fcm.ucsf.edu
FAU - Kumanyika, Shiriki
AU  - Kumanyika S
FAU - Fielding, Jonathan
AU  - Fielding J
FAU - Laveist, Thomas
AU  - Laveist T
FAU - Borrell, Luisa N
AU  - Borrell LN
FAU - Manderscheid, Ron
AU  - Manderscheid R
FAU - Troutman, Adewale
AU  - Troutman A
LA  - eng
GR  - R24 HD042854/HD/NICHD NIH HHS/United States
PT  - Journal Article
DEP - 20110506
PL  - United States
TA  - Am J Public Health
JT  - American journal of public health
JID - 1254074
SB  - IM
MH  - *Health Policy
MH  - *Health Status Disparities
MH  - Healthy People Programs
MH  - Humans
MH  - Principle-Based Ethics
MH  - Social Justice
MH  - Social Values
MH  - United States
MH  - Vulnerable Populations
PMC - PMC3222512
EDAT- 2011/05/10 06:00
MHDA- 2012/01/18 06:00
CRDT- 2011/05/10 06:00
PHST- 2011/05/10 06:00 [entrez]
PHST- 2011/05/10 06:00 [pubmed]
PHST- 2012/01/18 06:00 [medline]
AID - AJPH.2010.300062 [pii]
AID - 10.2105/AJPH.2010.300062 [doi]
PST - ppublish
SO  - Am J Public Health. 2011 Dec;101 Suppl 1:S149-55. doi: 10.2105/AJPH.2010.300062. 
      Epub 2011 May 6.


PMID- 21551372
OWN - NLM
STAT- MEDLINE
DCOM- 20120208
LR  - 20111011
IS  - 1708-8283 (Electronic)
IS  - 0883-0738 (Linking)
VI  - 26
IP  - 10
DP  - 2011 Oct
TI  - Ethics in health care services for young persons with neurodevelopmental
      disabilities: a focus on cerebral palsy.
PG  - 1221-9
LID - 10.1177/0883073811402074 [doi]
AB  - In this article we review and discuss some of the key ethical and social
      challenges that young persons with cerebral palsy face in health care delivery.
      We identify and explain these challenges, some of which are rarely discussed in
      contemporary medicine and biomedical ethics, partly because they are not
      considered genuine "ethical" challenges per se. Most of these challenges are
      heavily shaped by broader social context and institutional practices, which
      highlights the importance of nonbiological aspects of the care of young persons
      with cerebral palsy from an ethics standpoint.
FAU - Lariviere-Bastien, Danae
AU  - Lariviere-Bastien D
AD  - Neuroethics Research Unit, Institut de recherches cliniques de Montreal, QC,
      Canada.
FAU - Racine, Eric
AU  - Racine E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110506
PL  - United States
TA  - J Child Neurol
JT  - Journal of child neurology
JID - 8606714
SB  - IM
MH  - *Cerebral Palsy/complications/diagnosis/therapy
MH  - Databases, Factual/statistics & numerical data
MH  - Delivery of Health Care/*ethics
MH  - *Developmental Disabilities/complications/diagnosis/therapy
MH  - Health Communication/ethics
MH  - Health Services/*ethics
MH  - Humans
MH  - Medical Informatics
EDAT- 2011/05/10 06:00
MHDA- 2012/02/09 06:00
CRDT- 2011/05/10 06:00
PHST- 2011/05/10 06:00 [entrez]
PHST- 2011/05/10 06:00 [pubmed]
PHST- 2012/02/09 06:00 [medline]
AID - 0883073811402074 [pii]
AID - 10.1177/0883073811402074 [doi]
PST - ppublish
SO  - J Child Neurol. 2011 Oct;26(10):1221-9. doi: 10.1177/0883073811402074. Epub 2011 
      May 6.


PMID- 21551348
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20110921
IS  - 1525-3163 (Electronic)
IS  - 0021-8812 (Linking)
VI  - 89
IP  - 10
DP  - 2011 Oct
TI  - Genetic analysis of the longevity of French sport horses in jumping competition.
PG  - 2988-94
LID - 10.2527/jas.2011-3931 [doi]
AB  - The longevity of sport horses is an economic and ethical issue. The aim of this
      study was to analyze the duration of the competitive life of jumping horses in
      France to assess the potential for genetic evaluation and to propose rules of
      management for sport horses. Data included lifetimes spent in jumping
      competitions for the 209,296 horses born from 1968 onward with performances
      between 1972 and 2008; the data set contained 22% right-censored records.
      Longevity was measured in years. Discrete survival analysis included fixed
      effects of region of birth, month of birth, year of recording, age at first
      competition, interaction between sex and level of jumping performance as measured
      by the logarithm of earnings adjusted for sex, age, year, and random sire and
      maternal grand-sire effects. There were 16,668 sires and maternal grand-sires.
      All fixed effects were highly significant (P < 0.001). Management of the sports
      career had an important effect on longevity: against common belief, the younger
      the horse started competing, the longer it stayed in competition. For horses that
      started competing at an age of 6 yr, the risk of culling was 1.33-fold that of
      horses having started at 4 yr of age. The less success in competition, the
      greater was the chance for leaving competition, especially for horses without
      earnings. For a gelding without earnings, the risk of culling was 1.40-fold that 
      of an average-performance gelding and 2.57-fold that of a top-rated gelding
      (performance at least 2 SD above the mean). Mares always had greater relative
      risk than geldings or stallions because they may be culled from competition to be
      used for breeding. The risk of culling for females was 1.45-fold that of a
      gelding with the same performance. The heritability of the length of competitive 
      life was 0.10. Breeding values were predicted for sires, and 3,303 sires showed
      an accuracy greater than 0.60. Among these sires, 262 were used for breeding in
      2008.
FAU - Ricard, A
AU  - Ricard A
AD  - INRA, UMR 1313, 78352 Jouy-en-Josas, France. anne.ricard@toulouse.inra.fr
FAU - Blouin, C
AU  - Blouin C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110506
PL  - United States
TA  - J Anim Sci
JT  - Journal of animal science
JID - 8003002
SB  - IM
MH  - Animals
MH  - Breeding
MH  - Female
MH  - France
MH  - Genetic Variation
MH  - Horses/*genetics/*physiology
MH  - Male
MH  - Sports/*standards
MH  - Time Factors
EDAT- 2011/05/10 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/05/10 06:00
PHST- 2011/05/10 06:00 [entrez]
PHST- 2011/05/10 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - jas.2011-3931 [pii]
AID - 10.2527/jas.2011-3931 [doi]
PST - ppublish
SO  - J Anim Sci. 2011 Oct;89(10):2988-94. doi: 10.2527/jas.2011-3931. Epub 2011 May 6.


PMID- 21551132
OWN - NLM
STAT- MEDLINE
DCOM- 20110823
LR  - 20161020
IS  - 1941-2479 (Electronic)
IS  - 1010-5395 (Linking)
VI  - 23
IP  - 3
DP  - 2011 May
TI  - Pandemic preparedness in Asia: a role for law and ethics?
PG  - 419-30
LID - 10.1177/1010539511408411 [doi]
AB  - Management of pandemic influenza relies on complex coordination of many different
      dimensions of the health and social care systems, emergency services, levels of
      national and local government, civil society, communications and media, and
      cultural expectations. Law is one small but important component of those
      arrangements, which touch on fundamental ethical debates. This review
      demonstrates that the Asian region is actively engaging those issues in diverse
      ways in light of their varied socioeconomic and cultural backgrounds, but scope
      remains for prioritising further research into these relationships.
FAU - Bennett, Belinda
AU  - Bennett B
AD  - Faculty of Law, University of Sydney, Sydney, New South Wales, Australia.
      belinda.bennett@sydney.edu.au
FAU - Carney, Terry
AU  - Carney T
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110505
PL  - China
TA  - Asia Pac J Public Health
JT  - Asia-Pacific journal of public health
JID - 8708538
SB  - IM
MH  - Asia/epidemiology
MH  - Bioethical Issues
MH  - Disaster Planning/legislation & jurisprudence/*organization & administration
MH  - Humans
MH  - Influenza, Human/epidemiology/*prevention & control
MH  - Pandemics/*prevention & control
EDAT- 2011/05/10 06:00
MHDA- 2011/08/24 06:00
CRDT- 2011/05/10 06:00
PHST- 2011/05/10 06:00 [entrez]
PHST- 2011/05/10 06:00 [pubmed]
PHST- 2011/08/24 06:00 [medline]
AID - 1010539511408411 [pii]
AID - 10.1177/1010539511408411 [doi]
PST - ppublish
SO  - Asia Pac J Public Health. 2011 May;23(3):419-30. doi: 10.1177/1010539511408411.
      Epub 2011 May 5.


PMID- 21550854
OWN - NLM
STAT- MEDLINE
DCOM- 20111219
LR  - 20110715
IS  - 1472-6491 (Electronic)
IS  - 1472-6483 (Linking)
VI  - 23
IP  - 1
DP  - 2011 Jul
TI  - Current practice in tubal surgery and adhesion management: a review.
PG  - 53-62
LID - 10.1016/j.rbmo.2011.03.018 [doi]
AB  - The diminished role of tubal surgery in infertile women following widespread
      access to IVF is now being reviewed as more patients and surgeons today consider 
      tubal surgery as an effective alternative to assisted reproduction treatment in
      certain circumstances. The limitations of and lack of patient acceptance of
      assisted reproduction treatment for ethical and moral reasons have contributed to
      this change as well as advances in surgical techniques and instrument technology,
      notably developments in endoscopic surgery. Strategies in tubal surgery are
      largely unchanged but the mini-invasive nature of the endoscopic approach has
      added value because of less tissue trauma, better visualization of the operative 
      field and more rapid healing, which make surgery using today's techniques an
      integral part of the treatment strategy in infertile couples.
CI  - Copyright (c) 2011 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All
      rights reserved.
FAU - Watrelot, A
AU  - Watrelot A
AD  - Centre de Recherche et d'Etude de la Sterilite (CRES), Lyon, France.
      watrelot@wanadoo.fr
FAU - Chauvin, G
AU  - Chauvin G
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110327
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
SB  - IM
MH  - Fallopian Tube Diseases/pathology/*surgery
MH  - Fallopian Tubes/pathology/*surgery
MH  - Female
MH  - Gynecologic Surgical Procedures/instrumentation/*methods
MH  - Humans
MH  - Reproductive Techniques, Assisted
MH  - Tissue Adhesions/*prevention & control
EDAT- 2011/05/10 06:00
MHDA- 2011/12/20 06:00
CRDT- 2011/05/10 06:00
PHST- 2010/06/23 00:00 [received]
PHST- 2011/03/13 00:00 [revised]
PHST- 2011/03/22 00:00 [accepted]
PHST- 2011/05/10 06:00 [entrez]
PHST- 2011/05/10 06:00 [pubmed]
PHST- 2011/12/20 06:00 [medline]
AID - S1472-6483(11)00174-X [pii]
AID - 10.1016/j.rbmo.2011.03.018 [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2011 Jul;23(1):53-62. doi: 10.1016/j.rbmo.2011.03.018. Epub
      2011 Mar 27.


PMID- 21550673
OWN - NLM
STAT- MEDLINE
DCOM- 20130128
LR  - 20131121
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 160
IP  - 2
DP  - 2012 Oct 4
TI  - Myocardial extraction of intracellular magnesium and atrial fibrillation after
      coronary surgery.
PG  - 114-8
LID - 10.1016/j.ijcard.2011.04.015 [doi]
AB  - BACKGROUND: The effects of magnesium loading on the incidence of atrial
      fibrillation following coronary artery bypass graft surgery (CAGB) are equivocal.
      None of the previous studies assessed the influence of myocardial extraction of
      magnesium in these settings. The current trial aims to elucidate whether the
      incidence of atrial fibrillation following CABG is affected by the preoperative
      rate of myocardial extraction of magnesium. METHODS: The ethical committee
      approved the study protocol. 113 patients (94 male, mean age 63 +/- 11 years)
      planned for elective CABG surgery under normothermic cardiopulmonary bypass were 
      prospectively included. Preoperative independent variables included preoperative 
      treatment, electrocardiographic abnormalities, left ventricular ejection fraction
      estimation, left atrial size, creatinine clearance and assays of plasma and
      intracellular magnesium, calcium, albumin, potassium and ionized calcium, drawn
      preoperatively from the coronary sinus and the aortic root. The covariates -
      including the rate of myocardial extraction of magnesium - were entered in a
      logistic regression model to predict the odds of atrial fibrillation. RESULTS:
      The incidence of post operative atrial fibrillation was 16%. A rate of myocardial
      extraction of intracellular magnesium >/= 7% increases fivefold the multivariate 
      risk of postoperative atrial fibrillation (p < .01). Advanced age was also
      significantly associated to postoperative atrial fibrillation. CONCLUSIONS: This 
      study suggests that a preoperative rate of myocardial extraction of intracellular
      magnesium >/= 7% could be a new and a potent predictive factor for postoperative 
      atrial fibrillation.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Abdel-Massih, Tony E
AU  - Abdel-Massih TE
AD  - Department of Cardiology, Hotel-Dieu de France Hospital, Achrafieh, Beirut,
      Lebanon.
FAU - Sarkis, Antoine
AU  - Sarkis A
FAU - Sleilaty, Ghassan
AU  - Sleilaty G
FAU - El Rassi, Issam
AU  - El Rassi I
FAU - Chamandi, Chucralla
AU  - Chamandi C
FAU - Karam, Nicole
AU  - Karam N
FAU - Haddad, Fadia
AU  - Haddad F
FAU - Yazigi, Alexandre
AU  - Yazigi A
FAU - Madi-Jebara, Samia
AU  - Madi-Jebara S
FAU - Yazbeck, Patricia
AU  - Yazbeck P
FAU - El Asmar, Bechara
AU  - El Asmar B
FAU - Ashoush, Ramzi
AU  - Ashoush R
FAU - Jebara, Victor
AU  - Jebara V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110507
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
RN  - I38ZP9992A (Magnesium)
SB  - IM
MH  - Atrial Fibrillation/epidemiology/*etiology/*metabolism
MH  - Coronary Artery Bypass/adverse effects
MH  - Female
MH  - Humans
MH  - Intracellular Space
MH  - Magnesium/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*metabolism
MH  - Prospective Studies
EDAT- 2011/05/10 06:00
MHDA- 2013/01/29 06:00
CRDT- 2011/05/10 06:00
PHST- 2010/04/20 00:00 [received]
PHST- 2011/03/31 00:00 [revised]
PHST- 2011/04/14 00:00 [accepted]
PHST- 2011/05/10 06:00 [entrez]
PHST- 2011/05/10 06:00 [pubmed]
PHST- 2013/01/29 06:00 [medline]
AID - S0167-5273(11)00362-7 [pii]
AID - 10.1016/j.ijcard.2011.04.015 [doi]
PST - ppublish
SO  - Int J Cardiol. 2012 Oct 4;160(2):114-8. doi: 10.1016/j.ijcard.2011.04.015. Epub
      2011 May 7.


PMID- 21550542
OWN - NLM
STAT- MEDLINE
DCOM- 20110708
LR  - 20110509
IS  - 1521-6896 (Print)
IS  - 1521-6896 (Linking)
VI  - 25
IP  - 2
DP  - 2011 Jun
TI  - Managing the aftermath of critical incidents: meeting the needs of health-care
      providers and patients.
PG  - 169-79
LID - 10.1016/j.bpa.2011.02.004 [doi]
AB  - Critical incidents may have serious psychological and health-related impact on
      patients, their families and the health-care providers involved. Exploring the
      needs of health-care providers and patients and their families in the aftermath
      of a critical incident, this article highlights a disconnect between the widely
      acknowledged ethical obligation for open disclosure and current practice, reviews
      the available evidence on effective disclosure and barriers to open disclosure
      and provides an overview of what health-care organisations can do to alleviate
      the impact of critical incidents on staff, patients and their families. The most 
      critical elements are: (1) effective support systems for clinicians, (2)
      guidelines on critical incident management including immediate measures,
      disclosure standards and subsequent incident analysis and (3) educational
      interventions informing staff about disclosure standards and support systems and 
      training critical disclosure skills. Significant leadership commitment is
      required to successfully implement such comprehensive incident management
      systems.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Manser, Tanja
AU  - Manser T
AD  - University of Fribourg, Department of Psychology, Industrial Psychology and Human
      Factors Group, Rue P.-A. de Faucigny 2, CH-1700 Fribourg, Fribourg, Switzerland. 
      tanja.manser@unifr.ch
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Best Pract Res Clin Anaesthesiol
JT  - Best practice & research. Clinical anaesthesiology
JID - 101121446
SB  - IM
MH  - Disclosure/standards
MH  - Health Personnel
MH  - Health Services Needs and Demand
MH  - Humans
MH  - Leadership
MH  - *Medical Errors
MH  - *Risk Management
EDAT- 2011/05/10 06:00
MHDA- 2011/07/09 06:00
CRDT- 2011/05/10 06:00
PHST- 2011/01/13 00:00 [received]
PHST- 2011/02/08 00:00 [revised]
PHST- 2011/02/15 00:00 [accepted]
PHST- 2011/05/10 06:00 [entrez]
PHST- 2011/05/10 06:00 [pubmed]
PHST- 2011/07/09 06:00 [medline]
AID - S1521-6896(11)00011-5 [pii]
AID - 10.1016/j.bpa.2011.02.004 [doi]
PST - ppublish
SO  - Best Pract Res Clin Anaesthesiol. 2011 Jun;25(2):169-79. doi:
      10.1016/j.bpa.2011.02.004.


PMID- 21549323
OWN - NLM
STAT- MEDLINE
DCOM- 20111003
LR  - 20160518
IS  - 1875-9777 (Electronic)
IS  - 1875-9777 (Linking)
VI  - 8
IP  - 5
DP  - 2011 May 6
TI  - The tragedy of translation: the case of "first use" in human embryonic stem cell 
      research.
PG  - 479-81
LID - 10.1016/j.stem.2011.04.009 [doi]
AB  - Who should go first in phase-I human trials when neither risks nor benefits can
      be estimated? By assessing concerns raised by Bretzner et al. (2011), we
      highlight a tragic dimension underlying all such trials. We discuss strategies to
      avoid the pitfalls of ethical hubris by promoting fidelity and trust.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Solbakk, Jan Helge
AU  - Solbakk JH
AD  - Centre for Medical Ethics, Faculty of Medicine, Institute of Health and Society, 
      University of Oslo, Oslo, Norway. j.h.solbakk@medisin.uio.no
FAU - Zoloth, Laurie
AU  - Zoloth L
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Cell Stem Cell
JT  - Cell stem cell
JID - 101311472
SB  - IM
CON - Cell Stem Cell. 2011 May 6;8(5):468-75. PMID: 21549321
MH  - Biomedical Research/ethics
MH  - Biotechnology
MH  - Clinical Trials, Phase I as Topic
MH  - Cost-Benefit Analysis
MH  - Humans
MH  - Patient Selection/*ethics
MH  - Risk Adjustment
MH  - Spinal Cord Injuries/economics/epidemiology/*therapy
MH  - Stem Cell Research
MH  - *Stem Cell Transplantation
EDAT- 2011/05/10 06:00
MHDA- 2011/10/04 06:00
CRDT- 2011/05/10 06:00
PHST- 2011/05/10 06:00 [entrez]
PHST- 2011/05/10 06:00 [pubmed]
PHST- 2011/10/04 06:00 [medline]
AID - S1934-5909(11)00174-3 [pii]
AID - 10.1016/j.stem.2011.04.009 [doi]
PST - ppublish
SO  - Cell Stem Cell. 2011 May 6;8(5):479-81. doi: 10.1016/j.stem.2011.04.009.


PMID- 21549321
OWN - NLM
STAT- MEDLINE
DCOM- 20111003
LR  - 20160518
IS  - 1875-9777 (Electronic)
IS  - 1875-9777 (Linking)
VI  - 8
IP  - 5
DP  - 2011 May 6
TI  - Target populations for first-in-human embryonic stem cell research in spinal cord
      injury.
PG  - 468-75
LID - 10.1016/j.stem.2011.04.012 [doi]
AB  - Geron recently announced that it had begun enrolling patients in the world's
      first-in-human clinical trial involving cells derived from human embryonic stem
      cells (hESCs). This trial raises important questions regarding the future of
      hESC-based therapies, especially in spinal cord injury (SCI) patients. We address
      some safety and efficacy concerns with this research, as well as the ethics of
      fair subject selection. We consider other populations that might be better for
      this research: chronic complete SCI patients for a safety trial, subacute
      incomplete SCI patients for an efficacy trial, and perhaps primary progressive
      multiple sclerosis (MS) patients for a combined safety and efficacy trial.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Bretzner, Frederic
AU  - Bretzner F
AD  - Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova
      Scotia B3H 3J5, Canada. frederic.bretzner@dal.ca
FAU - Gilbert, Frederic
AU  - Gilbert F
FAU - Baylis, Francoise
AU  - Baylis F
FAU - Brownstone, Robert M
AU  - Brownstone RM
LA  - eng
GR  - NNF 80045/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell Stem Cell
JT  - Cell stem cell
JID - 101311472
SB  - IM
CIN - Cell Stem Cell. 2011 May 6;8(5):476-8. PMID: 21549322
CIN - Cell Stem Cell. 2011 May 6;8(5):479-81. PMID: 21549323
MH  - Biotechnology/ethics/trends
MH  - Clinical Trials, Phase I as Topic
MH  - Cost-Benefit Analysis
MH  - Embryonic Stem Cells/*transplantation
MH  - Humans
MH  - Multiple Sclerosis/epidemiology/*therapy
MH  - Patient Rights
MH  - Patient Selection/*ethics
MH  - Risk Adjustment
MH  - Spinal Cord Injuries/economics/epidemiology/*therapy
MH  - *Stem Cell Research
MH  - *Stem Cell Transplantation
EDAT- 2011/05/10 06:00
MHDA- 2011/10/04 06:00
CRDT- 2011/05/10 06:00
PHST- 2011/05/10 06:00 [entrez]
PHST- 2011/05/10 06:00 [pubmed]
PHST- 2011/10/04 06:00 [medline]
AID - S1934-5909(11)00177-9 [pii]
AID - 10.1016/j.stem.2011.04.012 [doi]
PST - ppublish
SO  - Cell Stem Cell. 2011 May 6;8(5):468-75. doi: 10.1016/j.stem.2011.04.012.


PMID- 21548729
OWN - NLM
STAT- MEDLINE
DCOM- 20111025
LR  - 20181201
IS  - 1746-076X (Electronic)
IS  - 1746-0751 (Linking)
VI  - 6
IP  - 3
DP  - 2011 May
TI  - An ethical framework for expanded access to cell-based therapies.
PG  - 273-5
LID - 10.2217/rme.11.12 [doi]
FAU - Hoppe, Nils
AU  - Hoppe N
FAU - Denoon, Alexander
AU  - Denoon A
LA  - eng
PT  - Editorial
PL  - England
TA  - Regen Med
JT  - Regenerative medicine
JID - 101278116
SB  - IM
MH  - Cell- and Tissue-Based Therapy/*ethics/statistics & numerical data
MH  - Embryonic Stem Cells/cytology
MH  - European Union
MH  - Health Services Accessibility/ethics
MH  - Humans
MH  - Research Embryo Creation/ethics
MH  - Stem Cell Research/ethics
EDAT- 2011/05/10 06:00
MHDA- 2011/10/26 06:00
CRDT- 2011/05/10 06:00
PHST- 2011/05/10 06:00 [entrez]
PHST- 2011/05/10 06:00 [pubmed]
PHST- 2011/10/26 06:00 [medline]
AID - 10.2217/rme.11.12 [doi]
PST - ppublish
SO  - Regen Med. 2011 May;6(3):273-5. doi: 10.2217/rme.11.12.


PMID- 21548419
OWN - NLM
STAT- MEDLINE
DCOM- 20110614
LR  - 20110509
IS  - 0017-8012 (Print)
IS  - 0017-8012 (Linking)
VI  - 89
IP  - 5
DP  - 2011 May
TI  - The wise leader.
PG  - 58-67, 146
AB  - In an era of increasing discontinuity, wise leadership has nearly vanished. Many 
      leaders find it difficult to reinvent their corporations rapidly enough to cope
      with new technologies, demographic shifts, and consumption trends. They can't
      develop truly global organizations that operate effortlessly across borders. And 
      they find it tough to ensure that their people adhere to values and ethics. The
      authors assert that leaders must acquire practical wisdom, or what Aristotle
      called phronesis: experiential knowledge that enables people to make ethically
      sound judgments. Wise leaders demonstrate six abilities: (i) They make decisions 
      on the basis of what is good for the organization and for society. (2) They
      quickly grasp the essence of a situation and fathom the nature and meaning of
      people, things, and events. (3) They provide contexts in which executives and
      employees can interact to create new meaning. (4) They employ metaphors and
      stories to convert their experience into tacit knowledge that others can use. (5)
      They exert political power to bring people together and spur them to act. (6)
      They use apprenticeship and mentoring to cultivate practical wisdom in orders.
FAU - Nonaka, Ikujiro
AU  - Nonaka I
AD  - Hitotsubashi University, Tokyo.
FAU - Takeuchi, Hirotaka
AU  - Takeuchi H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Harv Bus Rev
JT  - Harvard business review
JID - 9875796
MH  - *Administrative Personnel
MH  - Humans
MH  - *Intelligence
MH  - *Leadership
MH  - Social Responsibility
MH  - United States
EDAT- 2011/05/10 06:00
MHDA- 2011/06/15 06:00
CRDT- 2011/05/10 06:00
PHST- 2011/05/10 06:00 [entrez]
PHST- 2011/05/10 06:00 [pubmed]
PHST- 2011/06/15 06:00 [medline]
PST - ppublish
SO  - Harv Bus Rev. 2011 May;89(5):58-67, 146.


PMID- 21548078
OWN - NLM
STAT- MEDLINE
DCOM- 20120110
LR  - 20220129
IS  - 1552-4930 (Electronic)
IS  - 1552-4922 (Linking)
VI  - 79
IP  - 10
DP  - 2011 Oct
TI  - Wormometry-on-a-chip: Innovative technologies for in situ analysis of small
      multicellular organisms.
PG  - 799-813
LID - 10.1002/cyto.a.21070 [doi]
AB  - Small multicellular organisms such as nematodes, fruit flies, clawed frogs, and
      zebrafish are emerging models for an increasing number of biomedical and
      environmental studies. They offer substantial advantages over cell lines and
      isolated tissues, providing analysis under normal physiological milieu of the
      whole organism. Many bioassays performed on these alternative animal models
      mirror with a high level of accuracy those performed on inherently
      low-throughput, costly, and ethically controversial mammalian models of human
      disease. Analysis of small model organisms in a high-throughput and high-content 
      manner is, however, still a challenging task not easily susceptible to laboratory
      automation. In this context, recent advances in photonics, electronics, as well
      as material sciences have facilitated the emergence of miniaturized bioanalytical
      systems collectively known as Lab-on-a-Chip (LOC). These technologies combine
      micro- and nanoscale sciences, allowing the application of laminar fluid flow at 
      ultralow volumes in spatially confined chip-based circuitry. LOC technologies are
      particularly advantageous for the development of a wide array of automated
      functionalities. The present work outlines the development of innovative
      miniaturized chip-based devices for the in situ analysis of small model
      organisms. We also introduce a new term "wormometry" to collectively distinguish 
      these up-and-coming chip-based technologies that go far beyond the conventional
      meaning of the term "cytometry."
CI  - Copyright (c) 2011 International Society for Advancement of Cytometry.
FAU - Wlodkowic, Donald
AU  - Wlodkowic D
AD  - Department of Chemistry and MacDiarmid Institute for Advanced Materials and
      Nanotechnology, University of Auckland, Auckland, 1142, New Zealand.
      d.wlodkowic@auckland.ac.nz
FAU - Khoshmanesh, Khashayar
AU  - Khoshmanesh K
FAU - Akagi, Jin
AU  - Akagi J
FAU - Williams, David E
AU  - Williams DE
FAU - Cooper, Jonathan M
AU  - Cooper JM
LA  - eng
GR  - BB/C511572/1/BB_/Biotechnology and Biological Sciences Research Council/United
      Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110504
PL  - United States
TA  - Cytometry A
JT  - Cytometry. Part A : the journal of the International Society for Analytical
      Cytology
JID - 101235694
RN  - 0 (Biological Products)
SB  - IM
MH  - Animals
MH  - Automation, Laboratory
MH  - Biological Products/pharmacology
MH  - Caenorhabditis elegans/anatomy & histology/*drug effects/physiology
MH  - Drosophila melanogaster/anatomy & histology/*drug effects/physiology
MH  - Flow Cytometry/instrumentation/*methods
MH  - *High-Throughput Screening Assays
MH  - Humans
MH  - Image Cytometry/instrumentation/*methods
MH  - Microfluidic Analytical Techniques/instrumentation/*methods
MH  - Models, Animal
MH  - Nanotechnology/instrumentation/methods
MH  - Oligonucleotide Array Sequence Analysis
MH  - Xenopus laevis/anatomy & histology/*physiology
MH  - Zebrafish/anatomy & histology/*physiology
EDAT- 2011/05/07 06:00
MHDA- 2012/01/11 06:00
CRDT- 2011/05/07 06:00
PHST- 2011/01/30 00:00 [received]
PHST- 2011/03/09 00:00 [revised]
PHST- 2011/03/30 00:00 [accepted]
PHST- 2011/05/07 06:00 [entrez]
PHST- 2011/05/07 06:00 [pubmed]
PHST- 2012/01/11 06:00 [medline]
AID - 10.1002/cyto.a.21070 [doi]
PST - ppublish
SO  - Cytometry A. 2011 Oct;79(10):799-813. doi: 10.1002/cyto.a.21070. Epub 2011 May 4.


PMID- 21548015
OWN - NLM
STAT- MEDLINE
DCOM- 20111013
LR  - 20120703
IS  - 1545-5017 (Electronic)
IS  - 1545-5009 (Linking)
VI  - 57
IP  - 4
DP  - 2011 Oct
TI  - Methodological and ethical aspects of randomized controlled clinical trials in
      minors with malignant diseases.
PG  - 599-605
LID - 10.1002/pbc.23171 [doi]
AB  - BACKGROUND: Due to the new European regulations for pediatric medications, future
      clinical trials will include an increasing number of minors. It is therefore
      important to reconsider and evaluate recent methodological and ethical aspects of
      clinical trials in minors. PROCEDURE: The following questions were investigated: 
      How are randomized controlled clinical trials (RCTs) performed in practice? Do
      investigators take into consideration biomedical ethical principles, explicated
      for example by Beauchamp and Childress, when planning and conducting a trial? The
      study was conducted in a descriptive manner. A systematic, algorithm-guided
      search focusing on RCTs in minors with malignant diseases was carried out in
      PubMed. One-thousand-nine-hundred-sixty-two publications from 2001 to 2005 were
      randomized in sequence. The first 1,000 publications were screened according to a
      priori defined inclusion criteria. One hundred seventy-five publications met the 
      criteria and were reviewed using the SIGN methodological checklist (2004), the
      CONSORT Statement (2001, section Methods, items 3-12) and indicators for ethical 
      aspects. Seventeen publications were checked by two raters. RESULTS: Information 
      on randomization and blinding was often equivocal. The publications were mainly
      rated positive for the criteria of the SIGN checklist, and mostly rated negative 
      for the additional items of the CONSORT Statement. Regarding the ethical
      principles, only few contributions were found in the publications. Inter-rater
      reliability was good. CONCLUSIONS: In the publications analyzed, we found only
      limited information concerning methods and reflections on ethical principles of
      the trials. Improvements are thus necessary and possible. We suggest how such
      trials and their respective publications can be optimized for these aspects.
CI  - Copyright (c) 2011 Wiley-Liss, Inc.
FAU - Rothenberger, Lillian G
AU  - Rothenberger LG
AD  - Department of Pediatric Hematology and Oncology, University Children's Hospital, 
      Muenster, Germany.
FAU - Henschel, Andreas Dirk
AU  - Henschel AD
FAU - Schrey, Dominik
AU  - Schrey D
FAU - Becker, Andreas
AU  - Becker A
FAU - Boos, Joachim
AU  - Boos J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110505
PL  - United States
TA  - Pediatr Blood Cancer
JT  - Pediatric blood & cancer
JID - 101186624
SB  - IM
EIN - Pediatr Blood Cancer. 2012 Jul 15;59(1):205
MH  - Humans
MH  - Minors
MH  - Neoplasms/*therapy
MH  - Randomized Controlled Trials as Topic/*ethics/*methods
MH  - Research Design/*standards
EDAT- 2011/05/07 06:00
MHDA- 2011/10/14 06:00
CRDT- 2011/05/07 06:00
PHST- 2010/08/27 00:00 [received]
PHST- 2011/03/28 00:00 [accepted]
PHST- 2011/05/07 06:00 [entrez]
PHST- 2011/05/07 06:00 [pubmed]
PHST- 2011/10/14 06:00 [medline]
AID - 10.1002/pbc.23171 [doi]
PST - ppublish
SO  - Pediatr Blood Cancer. 2011 Oct;57(4):599-605. doi: 10.1002/pbc.23171. Epub 2011
      May 5.


PMID- 21547649
OWN - NLM
STAT- MEDLINE
DCOM- 20110928
LR  - 20160707
IS  - 1437-1588 (Electronic)
IS  - 1436-9990 (Linking)
VI  - 54
IP  - 5
DP  - 2011 May
TI  - [Bariatric surgery in extremely obese children and adolescents].
PG  - 577-83
LID - 10.1007/s00103-011-1268-3 [doi]
AB  - The management of childhood obesity is a clinical dilemma. Validated and
      evidence-based intervention programs are still missing for this age group, and
      pediatricians increasingly see children with morbid obesity and with
      obesity-related comorbidities. For those extremely obese patients who failed to
      respond to the classical therapeutic approaches, bariatric surgery is a
      therapeutic option. Although available data for bariatric surgery in childhood
      and adolescence is limited to date, significant postoperative reduction in BMI
      and an evident improvement of preoperatively existing metabolic and
      cardiovascular comorbidities and psychosocial well-being have been reported. The 
      indication for bariatric surgery in adolescents follows strict criteria and
      should be proposed within an interdisciplinary team in specialized centers,
      including a clinical ethics committee. This review discusses the present
      guidelines for bariatric surgery in childhood and adolescence as well as
      available follow-up data for both adults and pediatric patients.
FAU - Bluher, S
AU  - Bluher S
AD  - Klinik und Poliklinik fur Kinder und Jugendliche, Department fur Frauen- und
      Kindermedizin, Universitatsklinikum Leipzig AoR, Deutschland.
      susann.blueher@medizin.uni-leipzig.de
FAU - Till, H
AU  - Till H
FAU - Kiess, W
AU  - Kiess W
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Bariatrische Chirurgie bei extremer Adipositas im Kindes- und Jugendalter.
PL  - Germany
TA  - Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
JT  - Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
JID - 101181368
SB  - IM
MH  - Adolescent
MH  - Bariatric Surgery/*methods/*trends
MH  - Child
MH  - Germany
MH  - Humans
MH  - Obesity, Morbid/*therapy
MH  - *Patient Selection
EDAT- 2011/05/07 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/05/07 06:00
PHST- 2011/05/07 06:00 [entrez]
PHST- 2011/05/07 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 10.1007/s00103-011-1268-3 [doi]
PST - ppublish
SO  - Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2011
      May;54(5):577-83. doi: 10.1007/s00103-011-1268-3.


PMID- 21547526
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20220410
IS  - 1432-1084 (Electronic)
IS  - 0938-7994 (Linking)
VI  - 21
IP  - 8
DP  - 2011 Aug
TI  - Distinguishing benign from malignant parotid gland tumours: low-dose multi-phasic
      CT protocol with 5-minute delay.
PG  - 1692-8
LID - 10.1007/s00330-011-2101-y [doi]
AB  - OBJECTIVES: To explore the percentage enhancement wash-out ratio (PEW) and
      relative PEW (RPEW) of low-dose multi-phasic computed tomography (CT) in
      distinguishing benign from malignant parotid gland tumours. METHODS: This study
      was approved by the ethics committee, and informed patient consent was obtained. 
      51 patients with parotid tumours proven by histopathology received CT, including 
      18 with pleomorphic adenomas, 14 with Warthin's tumours and 19 with malignant
      tumours. Size and attenuation of parotid tumours were measured. Compared with
      5-min attenuation, the 30-s and 90-s PEW (PEW(30,) PEW(90)) and RPEW (RPEW(30),
      RPEW(90)) were calculated. RESULTS: There was a significant difference in
      PEW(30), RPEW(30), PEW(90) and RPEW(90) in the parotid neoplasms groups (P <
      0.01), and statistical significance existed simultaneously in pleomorphic
      adenomas vs malignant tumours and Warthin's tumours vs malignant tumours
      according to SNK-q test. The optimal diagnosis results of malignancy with 100%
      specificity (32/32) was obtained by using a combination of the following
      criteria: -70% > PEW(30) < 36%, -30% > PEW(30) < 19%, PEW(90) > 12%, and the
      sensitivity (74%) for diagnosis of malignancy was yield. CONCLUSIONS: Wash-out
      ratio may assist in differentiating the benign from malignant parotid gland
      tumours. Combining the percentage of enhanced wash-out ratios of CT protocols can
      yield diagnostic results for malignancy.
FAU - Jin, G Q
AU  - Jin GQ
AD  - Department of Radiology, Oncology Hospital, Guangxi Medical University, Nanning, 
      People's Republic of China. jgq2011@126.com
FAU - Su, D K
AU  - Su DK
FAU - Xie, D
AU  - Xie D
FAU - Zhao, W
AU  - Zhao W
FAU - Liu, L D
AU  - Liu LD
FAU - Zhu, X N
AU  - Zhu XN
LA  - eng
PT  - Journal Article
DEP - 20110311
PL  - Germany
TA  - Eur Radiol
JT  - European radiology
JID - 9114774
RN  - 0 (Contrast Media)
RN  - 4419T9MX03 (Iohexol)
RN  - 712BAC33MZ (iopromide)
SB  - IM
MH  - Adenolymphoma/diagnostic imaging
MH  - Adenoma, Pleomorphic/diagnostic imaging
MH  - Adult
MH  - Aged
MH  - Analysis of Variance
MH  - Contrast Media
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Iohexol/analogs & derivatives
MH  - Male
MH  - Middle Aged
MH  - Parotid Neoplasms/*diagnostic imaging
MH  - ROC Curve
MH  - Radiation Dosage
MH  - Sensitivity and Specificity
MH  - Time Factors
MH  - Tomography, X-Ray Computed/*methods
PMC - PMC3128264
EDAT- 2011/05/07 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/05/07 06:00
PHST- 2010/11/12 00:00 [received]
PHST- 2011/02/18 00:00 [accepted]
PHST- 2011/02/12 00:00 [revised]
PHST- 2011/05/07 06:00 [entrez]
PHST- 2011/05/07 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/s00330-011-2101-y [doi]
PST - ppublish
SO  - Eur Radiol. 2011 Aug;21(8):1692-8. doi: 10.1007/s00330-011-2101-y. Epub 2011 Mar 
      11.


PMID- 21547491
OWN - NLM
STAT- MEDLINE
DCOM- 20111227
LR  - 20211020
IS  - 2035-5114 (Electronic)
IS  - 2035-5114 (Linking)
VI  - 95
IP  - 2
DP  - 2011 Aug
TI  - The effect of posterior instrumentation of the spine on canal dimensions and
      neurological recovery in thoracolumbar and lumbar burst fractures.
PG  - 101-6
LID - 10.1007/s12306-011-0111-1 [doi]
AB  - A prospective study was designed to determine whether posterior instrumentation
      of the spine in thoracolumbar and lumbar burst fractures produces indirect
      decompression of the spinal canal leading to better remodeling and neurological
      recovery. The study was conducted in Kasturba Medical College Manipal, India.
      Sixty-eight consecutive cases of thoracolumbar and lumbar burst fractures were
      treated by posterior instrumentation, and approval from the hospital ethical
      committee was obtained. The degree of initial spinal canal compromise, indirect
      decompression, and remodeling were assessed from the computed tomography scans.
      The neurological status at the time of presentation and at final follow-up was
      assessed by the American Spinal Injury Association's modified Frankel's grading. 
      The median canal compromise in patients with and without neurological deficit was
      47.32 and 39.33%, respectively. The overall mean canal compromise at the time of 
      admission, post-operative, and final follow-up were 47.37, 26.58 and 14.85%,
      respectively (P = <0.001). The median canal compromise in patients who recovered 
      was 44.5% and in those with no neurological recovery was 55.85%. The median
      percentage of canal decompression achieved in patients who recovered was 22.15%, 
      whereas it was 22% in those who did not recover. The median remodeling in
      recovered and non-recovered groups was 64.50 and 80%, respectively. None of these
      differences was statistically significant. This study shows that posterior
      instrumentation of the spine produces significant indirect decompression of the
      spinal canal and better remodeling. However, these factors may not improve the
      neurological recovery.
FAU - Mohanty, S P
AU  - Mohanty SP
AD  - Department of Orthopaedics, Division of Spine Surgery, Kasturba Medical College, 
      Manipal 576104, Karnataka, India.
FAU - Bhat, Shyamasunder N
AU  - Bhat SN
FAU - Ishwara-Keerthi, C
AU  - Ishwara-Keerthi C
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110310
PL  - Italy
TA  - Musculoskelet Surg
JT  - Musculoskeletal surgery
JID - 101498346
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Algorithms
MH  - Decompression, Surgical/*instrumentation/methods
MH  - Disability Evaluation
MH  - Female
MH  - Follow-Up Studies
MH  - Fracture Fixation/methods
MH  - Humans
MH  - Lumbar Vertebrae/injuries
MH  - Male
MH  - Middle Aged
MH  - Orthopedic Procedures/methods
MH  - Prospective Studies
MH  - Radiography
MH  - Reconstructive Surgical Procedures
MH  - *Recovery of Function
MH  - Risk Assessment
MH  - Severity of Illness Index
MH  - Spinal Canal/diagnostic imaging/injuries/*surgery
MH  - Spinal Fractures/diagnostic imaging/*physiopathology/rehabilitation/*surgery
MH  - Spinal Fusion/*instrumentation/methods
MH  - Thoracic Vertebrae/injuries
MH  - Treatment Outcome
EDAT- 2011/05/07 06:00
MHDA- 2011/12/28 06:00
CRDT- 2011/05/07 06:00
PHST- 2009/10/15 00:00 [received]
PHST- 2011/02/22 00:00 [accepted]
PHST- 2011/05/07 06:00 [entrez]
PHST- 2011/05/07 06:00 [pubmed]
PHST- 2011/12/28 06:00 [medline]
AID - 10.1007/s12306-011-0111-1 [doi]
PST - ppublish
SO  - Musculoskelet Surg. 2011 Aug;95(2):101-6. doi: 10.1007/s12306-011-0111-1. Epub
      2011 Mar 10.


PMID- 21546522
OWN - NLM
STAT- MEDLINE
DCOM- 20120301
LR  - 20151119
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 11
DP  - 2011 Nov
TI  - Ethical issues in the development of tele-ICUs.
PG  - 655-7
LID - 10.1136/jme.2010.040311 [doi]
AB  - The past two decades have seen a dramatic increase in the use of telemedicine
      while the information technology revolution has contributed significantly to its 
      popularity. In addition, there has been a recent increase in the use of
      telemedicine in the intensive care unit (ICU), partially driven by a critical
      shortage of intensivists. However, the ethical questions raised by the
      implementation of tele-ICUs have not been adequately considered. In this essay,
      we will discuss the development of tele-ICUs from the perspective of autonomy,
      beneficence/non-malificence, justice and professionalism.
FAU - Nesher, Lior
AU  - Nesher L
AD  - Division of Internal Medicine, Soroka University Medical Center, Beer Sheva,
      Israel. nesherke@bgu.ac.il
FAU - Jotkowitz, Alan
AU  - Jotkowitz A
LA  - eng
PT  - Journal Article
DEP - 20110505
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Cost-Benefit Analysis
MH  - Critical Care/economics/*ethics/standards
MH  - Humans
MH  - Intensive Care Units
MH  - Israel
MH  - Personnel Staffing and Scheduling/economics
MH  - Remote Consultation/*ethics
MH  - Telemedicine/economics/*ethics/standards
EDAT- 2011/05/07 06:00
MHDA- 2012/03/02 06:00
CRDT- 2011/05/07 06:00
PHST- 2011/05/07 06:00 [entrez]
PHST- 2011/05/07 06:00 [pubmed]
PHST- 2012/03/02 06:00 [medline]
AID - jme.2010.040311 [pii]
AID - 10.1136/jme.2010.040311 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Nov;37(11):655-7. doi: 10.1136/jme.2010.040311. Epub 2011 May 
      5.


PMID- 21546521
OWN - NLM
STAT- MEDLINE
DCOM- 20120103
LR  - 20181201
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 10
DP  - 2011 Oct
TI  - Managing the public health risk of a 'sex worker' with hepatitis B infection:
      legal and ethical considerations.
PG  - 623-6
LID - 10.1136/jme.2010.041293 [doi]
AB  - This paper examines the ethical issues faced by health workers managing a
      fictional case of a female sex worker who is hepatitis B positive with a high
      level of virus but is asymptomatic. According to guidelines she does not require 
      treatment herself, but is potentially highly infectious to others. Recent legal
      cases in the UK show it can be criminal to pass on HIV or hepatitis B infection
      sexually if the risk is known and the partner has not been informed. However,
      there is no statute or case law showing that health workers are required to
      intervene to prevent such a potential 'crime', particularly when the partners are
      unknown, as in this case. The health workers could respond in various ways. They 
      could do nothing, thus making further infection probable. They could advise the
      sex worker to use condoms and to inform her clients. They could treat the sex
      worker to reduce her level of infectivity, although there is no benefit to her.
      They could disclose the sex worker's status, although breaking confidentiality is
      a serious matter ethically and may be of no benefit to the unknown client group. 
      Regulating prostitution might help; but sex workers with infection may work off
      licence. This paper discusses the clinical, moral and ethical issues associated
      with such a scenario and concludes that the most beneficial course is to target
      clients, through health education, to recognise the potential risks of infection 
      from a sex worker and to take suitable precautions including immunisation against
      hepatitis B.
FAU - Poll, Ray
AU  - Poll R
AD  - The Department of Infection and Tropical Medicine, Sheffield Teaching Hospitals
      NHS Trust, The Royal Hallamshire Hospital, Glossop Road, Sheffield, UK.
      ray.poll@sth.nhs.uk
LA  - eng
PT  - Journal Article
DEP - 20110505
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Attitude to Health
MH  - Condoms/*statistics & numerical data
MH  - Female
MH  - Health Education/*ethics
MH  - Hepatitis B/*prevention & control/psychology
MH  - Humans
MH  - *Public Health
MH  - Risk Factors
MH  - Sex Workers/*psychology
MH  - Sexual Behavior/psychology
MH  - Sexually Transmitted Diseases/*prevention & control/psychology
EDAT- 2011/05/07 06:00
MHDA- 2012/01/04 06:00
CRDT- 2011/05/07 06:00
PHST- 2011/05/07 06:00 [entrez]
PHST- 2011/05/07 06:00 [pubmed]
PHST- 2012/01/04 06:00 [medline]
AID - jme.2010.041293 [pii]
AID - 10.1136/jme.2010.041293 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Oct;37(10):623-6. doi: 10.1136/jme.2010.041293. Epub 2011 May 
      5.


PMID- 21546520
OWN - NLM
STAT- MEDLINE
DCOM- 20120224
LR  - 20211203
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 9
DP  - 2011 Sep
TI  - The justification of race in biological explanation.
PG  - 535-9
LID - 10.1136/jme.2011.043752 [doi]
AB  - In medicine, racial differences are frequently presented as part of the best
      explanation of differences in the risk of diseases. The problem of using racial
      classification in biomedical research has become important because of its ethical
      consequences in society. However, the biological relevance of the concept of race
      cannot be established by any ethical argument and the epistemological role of
      racial categorisation requires clarification. In this paper, different issues
      related to the concept of race are considered. This paper analyses the semantic
      problem concerning the definition of race, considers the ontological problem of
      race, drawing attention to the biological evidence for genetic differences among 
      human groups, and presents a promising epistemological approach to the problem of
      race. The purpose of the paper is to examine whether, or when, racial categories 
      belong in biological explanations. It shows that the concept of race cannot be
      justified in biology because it does not lead to successful predictions, and that
      genetic discontinuities are sufficient to explain differences in diseases but not
      needed in the explanation. The biomedical field should search for genetic
      patterns related to diseases, and should not assume racial discontinuities among 
      human groups and use racial clusters as proxies for undetected genetic patterns.
FAU - Lorusso, Ludovica
AU  - Lorusso L
AD  - University of Sassari, Via Torre Tonda 34, 07100, Sassari, Italy.
      lorusso@uniss.it
LA  - eng
PT  - Journal Article
DEP - 20110505
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Bias
MH  - Biomedical Research/trends
MH  - Ethics, Medical
MH  - Ethnicity/*genetics
MH  - *Genetic Predisposition to Disease
MH  - Genetic Variation
MH  - *Genetics, Population
MH  - Health Status Disparities
MH  - Humans
MH  - Racial Groups/*genetics
MH  - Semantics
EDAT- 2011/05/07 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/05/07 06:00
PHST- 2011/05/07 06:00 [entrez]
PHST- 2011/05/07 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - jme.2011.043752 [pii]
AID - 10.1136/jme.2011.043752 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Sep;37(9):535-9. doi: 10.1136/jme.2011.043752. Epub 2011 May
      5.


PMID- 21546261
OWN - NLM
STAT- MEDLINE
DCOM- 20111102
LR  - 20110603
IS  - 1036-7314 (Print)
IS  - 1036-7314 (Linking)
VI  - 24
IP  - 2
DP  - 2011 May
TI  - Explicit declaration of ethical approval for clinical research.
PG  - 89
LID - 10.1016/j.aucc.2011.04.001 [doi]
FAU - Eastwood, Glenn M
AU  - Eastwood GM
LA  - eng
PT  - Letter
DEP - 20110504
PL  - Australia
TA  - Aust Crit Care
JT  - Australian critical care : official journal of the Confederation of Australian
      Critical Care Nurses
JID - 9207852
CIN - Aust Crit Care. 2011 May;24(2):90. PMID: 21530303
MH  - Biomedical Research/*ethics
MH  - Clinical Trials as Topic/ethics
MH  - Ethics, Clinical
MH  - Ethics, Research
MH  - *Helsinki Declaration
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - *Journalism, Medical
MH  - *Periodicals as Topic
EDAT- 2011/05/07 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/05/07 06:00
PHST- 2011/03/31 00:00 [received]
PHST- 2011/04/12 00:00 [accepted]
PHST- 2011/05/07 06:00 [entrez]
PHST- 2011/05/07 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
AID - S1036-7314(11)00052-X [pii]
AID - 10.1016/j.aucc.2011.04.001 [doi]
PST - ppublish
SO  - Aust Crit Care. 2011 May;24(2):89. doi: 10.1016/j.aucc.2011.04.001. Epub 2011 May
      4.


PMID- 21546180
OWN - NLM
STAT- MEDLINE
DCOM- 20130110
LR  - 20220409
IS  - 1872-7727 (Electronic)
IS  - 0720-048X (Linking)
VI  - 81
IP  - 8
DP  - 2012 Aug
TI  - Mapping the brain in type II diabetes: Voxel-based morphometry using DARTEL.
PG  - 1870-6
LID - 10.1016/j.ejrad.2011.04.025 [doi]
AB  - PURPOSE: To investigate the pattern of brain volume changes of the brain in
      patients with type II diabetes mellitus using voxel-based morphometry. MATERIAL
      AND METHODS: Institutional ethics approval and informed consent were obtained.
      VBM based on the high resolution three-dimensional T1-weighted fast spoiled
      gradient recalled echo MRI images was obtained from 16 type II diabetes patients 
      (mean age 61.2 years) and 16 normal controls (mean age 59.6 years). All images
      were spatially preprocessed using Diffeomorphic Anatomical Registration using
      Exponentiated Lie algebra (DARTEL) algorithm, and the DARTEL templates were made 
      from 100 normal subjects. Statistical parametric mapping was generated using
      analysis of covariance (ANCOVA). RESULTS: An atrophy pattern of gray matter was
      seen in type II diabetes patients compared with controls that involved the right 
      superior, middle, and inferior temporal gyri, right precentral gyrus, and left
      rolandic operculum region. The loss of white matter volume in type II diabetes
      mellitus was observed in right temporal lobe and left inferior frontal triangle
      region. ROI analysis revealed that the gray and white matter volume of right
      temporal lobe were significant lower in type II diabetes mellitus than that in
      controls (P<0.05). CONCLUSION: This work demonstrated that type II diabetes
      mellitus patients mainly exhibited gray and white matter atrophy in right
      temporal lobe, and this finding supported that type II diabetes mellitus could
      lead to subtle diabetic brain structural changes in patients without dementia or 
      macrovascular complications.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Chen, Zhiye
AU  - Chen Z
AD  - Department of Radiology, PLA General Hospital, 28 Fuxing Road, Beijing 100853,
      China.
FAU - Li, Lin
AU  - Li L
FAU - Sun, Jie
AU  - Sun J
FAU - Ma, Lin
AU  - Ma L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110505
PL  - Ireland
TA  - Eur J Radiol
JT  - European journal of radiology
JID - 8106411
SB  - IM
MH  - Aged
MH  - Brain/*pathology
MH  - Diabetes Mellitus, Type 2/*pathology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers, Myelinated/*pathology
MH  - Neurons/*pathology
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
EDAT- 2011/05/07 06:00
MHDA- 2013/01/11 06:00
CRDT- 2011/05/07 06:00
PHST- 2011/02/24 00:00 [received]
PHST- 2011/04/06 00:00 [accepted]
PHST- 2011/05/07 06:00 [entrez]
PHST- 2011/05/07 06:00 [pubmed]
PHST- 2013/01/11 06:00 [medline]
AID - S0720-048X(11)00404-9 [pii]
AID - 10.1016/j.ejrad.2011.04.025 [doi]
PST - ppublish
SO  - Eur J Radiol. 2012 Aug;81(8):1870-6. doi: 10.1016/j.ejrad.2011.04.025. Epub 2011 
      May 5.


PMID- 21545854
OWN - NLM
STAT- MEDLINE
DCOM- 20120202
LR  - 20211203
IS  - 1743-9159 (Electronic)
IS  - 1743-9159 (Linking)
VI  - 9
IP  - 5
DP  - 2011
TI  - Facial transplantation revisited: findings from the very first public engagement 
      exercise.
PG  - 433-6
LID - 10.1016/j.ijsu.2011.04.005 [doi]
AB  - OBJECTIVES: Facial transplantation has emerged as a treatment option in facial
      reconstruction. In this pilot study, we investigate initial attitudes to this
      concept in relevant patient and health professional groups. METHOD: Attitudes
      towards facial transplantation as a procedure were examined among 200
      participants, including 30 nurses, 30 doctors, 30 plastic surgeons, 30 renal
      transplant patients, 30 medical students, 30 members of the lay public and 20
      patients with facial disfigurements through the use of a questionnaire. RESULTS: 
      Identity was important for all participating groups with 83.5% positive about
      receiving a facial transplant provided no resemblance to donor. There was an
      inverse relationship between the side effects of the immunosuppressant regimen
      and organ rejection and the willingness to undergo facial transplantation when
      compared to other forms of organ transplantation. A relationship to the recipient
      and familiarity with a transplant programme were positively related to potential 
      donation. CONCLUSION: This study identifies the key issues of altered identity
      and the understanding of immunosuppression and surgical risk as the focus for
      research and patient selection. The ethical aspects of facial transplantation are
      not addressed in this study, and have been addressed elsewhere.
CI  - Copyright (c) 2011 Surgical Associates Ltd. Published by Elsevier Ltd. All rights
      reserved.
FAU - Gwanmesia, Ivo
AU  - Gwanmesia I
AD  - Department of Plastic and Reconstructive Surgery, Royal Free Hampstead NHS Trust,
      Pond Street, Hampstead, London NW3 2QN, United Kingdom. gwanmesia@aol.com
FAU - Clarke, Alex
AU  - Clarke A
FAU - Butler, Peter E M
AU  - Butler PE
LA  - eng
PT  - Journal Article
DEP - 20110422
PL  - England
TA  - Int J Surg
JT  - International journal of surgery (London, England)
JID - 101228232
SB  - IM
CIN - Int J Surg. 2011;9(6):488-9. PMID: 21803178
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Attitude of Health Personnel
MH  - *Attitude to Health
MH  - Body Image
MH  - Facial Transplantation/*psychology
MH  - Female
MH  - Humans
MH  - *Immunosuppression Therapy
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - *Reconstructive Surgical Procedures/methods
MH  - Risk
MH  - Self Concept
MH  - Surveys and Questionnaires
MH  - Tissue Donors/psychology
EDAT- 2011/05/07 06:00
MHDA- 2012/02/03 06:00
CRDT- 2011/05/07 06:00
PHST- 2007/04/30 00:00 [received]
PHST- 2011/04/05 00:00 [revised]
PHST- 2011/04/13 00:00 [accepted]
PHST- 2011/05/07 06:00 [entrez]
PHST- 2011/05/07 06:00 [pubmed]
PHST- 2012/02/03 06:00 [medline]
AID - S1743-9191(11)00071-9 [pii]
AID - 10.1016/j.ijsu.2011.04.005 [doi]
PST - ppublish
SO  - Int J Surg. 2011;9(5):433-6. doi: 10.1016/j.ijsu.2011.04.005. Epub 2011 Apr 22.


PMID- 21545745
OWN - NLM
STAT- MEDLINE
DCOM- 20111026
LR  - 20211020
IS  - 1471-2458 (Electronic)
IS  - 1471-2458 (Linking)
VI  - 11
DP  - 2011 May 5
TI  - What could infant and young child nutrition learn from sweatshops?
PG  - 276
LID - 10.1186/1471-2458-11-276 [doi]
AB  - BACKGROUND: Adequate infant and young child nutrition demands high rates of
      breastfeeding and good access to nutrient rich complementary foods, requiring
      public sector action to promote breastfeeding and home based complementary
      feeding, and private sector action to refrain from undermining breastfeeding and 
      to provide affordable, nutrient rich complementary foods. Unfortunately, due to a
      lack of trust, the public and private sectors, from both the North and the South,
      do not work well together in achieving optimal infant and young child nutrition. 
      DISCUSSION: As the current debate in infant and young child nutrition is
      reminiscent of the "sweatshop" debate fifteen years ago, we argue that lessons
      from the sweatshops debate regarding cooperation between public and private
      sectors - and specific organizational experiences such as the Ethical Trading
      Initiative in which companies, trade unions, and civil society organizations work
      together to enhance implementation of labour standards and address alleged
      allegations - could serve as a model for improving cooperation and trust between 
      public, civil society and private groups, and ultimately health, in infant and
      young child nutrition. SUMMARY: Lessons from the sweatshops debate could serve as
      a model to promote cooperation and trust between public and private groups, such 
      that they learn to work together towards their common goal of improving infant
      and young child nutrition.
FAU - Singer, Peter A
AU  - Singer PA
AD  - McLaughlin-Rotman Centre for Global Health, University Health Network &
      University of Toronto, Toronto, Ontario, M5G 1L7, Canada.
      peter.singer@mrcglobal.org
FAU - Ansett, Sean
AU  - Ansett S
FAU - Sagoe-Moses, Isabella
AU  - Sagoe-Moses I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110505
PL  - England
TA  - BMC Public Health
JT  - BMC public health
JID - 100968562
SB  - IM
MH  - Adolescent
MH  - Breast Feeding
MH  - Child
MH  - Child Nutrition Disorders/*prevention & control
MH  - Humans
MH  - Infant
MH  - Infant Nutrition Disorders/*prevention & control
MH  - Infant, Newborn
MH  - *Learning
MH  - *Public-Private Sector Partnerships
PMC - PMC3103458
EDAT- 2011/05/07 06:00
MHDA- 2011/10/27 06:00
CRDT- 2011/05/07 06:00
PHST- 2010/11/17 00:00 [received]
PHST- 2011/05/05 00:00 [accepted]
PHST- 2011/05/07 06:00 [entrez]
PHST- 2011/05/07 06:00 [pubmed]
PHST- 2011/10/27 06:00 [medline]
AID - 1471-2458-11-276 [pii]
AID - 10.1186/1471-2458-11-276 [doi]
PST - epublish
SO  - BMC Public Health. 2011 May 5;11:276. doi: 10.1186/1471-2458-11-276.


PMID- 21545597
OWN - NLM
STAT- MEDLINE
DCOM- 20110712
LR  - 20110506
IS  - 1537-2995 (Electronic)
IS  - 0041-1132 (Linking)
VI  - 51
IP  - 5
DP  - 2011 May
TI  - Blood samples, repositories, and ethics.
PG  - 1123-5; author reply 1125
LID - 10.1111/j.1537-2995.2011.03065.x [doi]
FAU - Weiskopf, Richard B
AU  - Weiskopf RB
LA  - eng
PT  - Comment
PT  - Letter
PL  - United States
TA  - Transfusion
JT  - Transfusion
JID - 0417360
SB  - IM
CON - Transfusion. 2010 Sep;50(9):1866-9. PMID: 21050225
MH  - Biomedical Research/*ethics
MH  - Blood Banks/*ethics
MH  - Blood Donors/*ethics
MH  - Blood Preservation/*ethics
MH  - Humans
MH  - *Informed Consent
EDAT- 2011/05/07 06:00
MHDA- 2011/07/13 06:00
CRDT- 2011/05/07 06:00
PHST- 2011/05/07 06:00 [entrez]
PHST- 2011/05/07 06:00 [pubmed]
PHST- 2011/07/13 06:00 [medline]
AID - 10.1111/j.1537-2995.2011.03065.x [doi]
PST - ppublish
SO  - Transfusion. 2011 May;51(5):1123-5; author reply 1125. doi:
      10.1111/j.1537-2995.2011.03065.x.


PMID- 21545391
OWN - NLM
STAT- MEDLINE
DCOM- 20111103
LR  - 20110902
IS  - 1467-789X (Electronic)
IS  - 1467-7881 (Linking)
VI  - 12
IP  - 9
DP  - 2011 Sep
TI  - Ethics and prevention of overweight and obesity: an inventory.
PG  - 669-79
LID - 10.1111/j.1467-789X.2011.00880.x [doi]
AB  - Efforts to counter the rise in overweight and obesity, such as taxes on certain
      foods and beverages, limits to commercial advertising, a ban on chocolate drink
      at schools or compulsory physical exercise for obese employees, sometimes raise
      questions about what is considered ethically acceptable. There are obvious
      ethical incentives to these initiatives, such as improving individual and public 
      health, enabling informed choice and diminishing societal costs. Whereas we
      consider these positive arguments to put considerable effort in the prevention of
      overweight indisputable, we focus on potential ethical objections against such an
      effort. Our intention is to structure the ethical issues that may occur in
      programmes to prevent overweight and/or obesity in order to encourage further
      debate. We selected 60 recently reported interventions or policy proposals
      targeting overweight or obesity and systematically evaluated their ethically
      relevant aspects. Our evaluation was completed by discussing them in two expert
      meetings. We found that currently proposed interventions or policies to prevent
      overweight or obesity may (next to the benefits they strive for) include the
      following potentially problematic aspects: effects on physical health are
      uncertain or unfavourable; there are negative psychosocial consequences including
      uncertainty, fears and concerns, blaming and stigmatization and unjust
      discrimination; inequalities are aggravated; inadequate information is
      distributed; the social and cultural value of eating is disregarded; people's
      privacy is disrespected; the complexity of responsibilities regarding overweight 
      is disregarded; and interventions infringe upon personal freedom regarding
      lifestyle choices and raising children, regarding freedom of private enterprise
      or regarding policy choices by schools and other organizations. The obvious
      ethical incentives to combat the overweight epidemic do not necessarily override 
      the potential ethical constraints, and further debate is needed. An ethical
      framework to support decision makers in balancing potential ethical problems
      against the need to do something would be helpful. Developing programmes that are
      sound from an ethical point of view is not only valuable from a moral
      perspective, but may also contribute to preventing overweight and obesity, as
      societal objections to a programme may hamper its effectiveness.
CI  - (c) 2011 The Authors. obesity reviews (c) 2011 International Association for the 
      Study of Obesity.
FAU - ten Have, M
AU  - ten Have M
AD  - Department of Medical Ethics, Erasmus Medical Centre, Rotterdam, the Netherlands.
      m.tenhave@erasmusmc.nl
FAU - de Beaufort, I D
AU  - de Beaufort ID
FAU - Teixeira, P J
AU  - Teixeira PJ
FAU - Mackenbach, J P
AU  - Mackenbach JP
FAU - van der Heide, A
AU  - van der Heide A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110504
PL  - England
TA  - Obes Rev
JT  - Obesity reviews : an official journal of the International Association for the
      Study of Obesity
JID - 100897395
SB  - IM
MH  - Health Policy
MH  - Health Promotion/*ethics/*methods
MH  - Humans
MH  - Obesity/prevention & control
MH  - Overweight/*prevention & control
MH  - Public Health/*ethics
EDAT- 2011/05/07 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/05/07 06:00
PHST- 2011/05/07 06:00 [entrez]
PHST- 2011/05/07 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
AID - 10.1111/j.1467-789X.2011.00880.x [doi]
PST - ppublish
SO  - Obes Rev. 2011 Sep;12(9):669-79. doi: 10.1111/j.1467-789X.2011.00880.x. Epub 2011
      May 4.


PMID- 21545350
OWN - NLM
STAT- MEDLINE
DCOM- 20110909
LR  - 20110506
IS  - 1757-6199 (Electronic)
IS  - 1757-6180 (Linking)
VI  - 3
IP  - 9
DP  - 2011 May
TI  - GlaxoSmithKline's experience of incurred sample reanalysis for dried blood spot
      samples.
PG  - 1025-30
LID - 10.4155/bio.11.56 [doi]
AB  - Dried blood spots are becoming a popular alternative to plasma for many different
      applications. This has been driven by animal ethics but also by ease of use and
      cost savings. Recent regulatory guidance now has a requirement for incurred
      sample reanalysis. This article details three examples of incurred sample
      reanalysis using dried blood spot samples.
FAU - Barfield, Matthew
AU  - Barfield M
AD  - Platform Technology & Science, Drug Metabolism & Pharmacokinetics, Worldwide
      Bioanalysis & Systems Management, GlaxoSmithKline Pharmaceuticals, Park Road,
      Ware, Hertfordshire, UK. matthew.barfield@gsk.com
FAU - Ahmad, Sheelan
AU  - Ahmad S
FAU - Busz, Maria
AU  - Busz M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Bioanalysis
JT  - Bioanalysis
JID - 101512484
RN  - 0 (Reagent Strips)
SB  - IM
MH  - *Artifacts
MH  - Blood Chemical Analysis/*methods
MH  - Blood Specimen Collection/*methods
MH  - Chromatography, Liquid
MH  - Guidelines as Topic
MH  - Humans
MH  - Mass Spectrometry
MH  - Quality Control
MH  - Reagent Strips/*analysis
MH  - Reproducibility of Results
MH  - Validation Studies as Topic
EDAT- 2011/05/07 06:00
MHDA- 2011/09/10 06:00
CRDT- 2011/05/07 06:00
PHST- 2011/05/07 06:00 [entrez]
PHST- 2011/05/07 06:00 [pubmed]
PHST- 2011/09/10 06:00 [medline]
AID - 10.4155/bio.11.56 [doi]
PST - ppublish
SO  - Bioanalysis. 2011 May;3(9):1025-30. doi: 10.4155/bio.11.56.


PMID- 21544700
OWN - NLM
STAT- MEDLINE
DCOM- 20131122
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 18
IP  - 4
DP  - 2012 Dec
TI  - And lead us (not) into persuasion...? Persuasive technology and the ethics of
      communication.
PG  - 633-50
LID - 10.1007/s11948-011-9278-y [doi]
AB  - The paper develops ethical guidelines for the development and usage of persuasive
      technologies (PT) that can be derived from applying discourse ethics to this type
      of technologies. The application of discourse ethics is of particular interest
      for PT, since 'persuasion' refers to an act of communication that might be
      interpreted as holding the middle between 'manipulation' and 'convincing'. One
      can distinguish two elements of discourse ethics that prove fruitful when applied
      to PT: the analysis of the inherent normativity of acts of communication ('speech
      acts') and the Habermasian distinction between 'communicative' and 'strategic
      rationality' and their broader societal interpretation. This essay investigates
      what consequences can be drawn if one applies these two elements of discourse
      ethics to PT.
FAU - Spahn, Andreas
AU  - Spahn A
AD  - Ethics of Technology, School of Innovation Sciences, Eindhoven University of
      Technology, 5600 MB, Eindhoven, The Netherlands. a.spahn@tue.nl
LA  - eng
PT  - Journal Article
DEP - 20110505
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Communication
MH  - *Guidelines as Topic
MH  - Humans
MH  - *Persuasive Communication
MH  - Technology/*ethics
PMC - PMC3513602
EDAT- 2011/05/06 06:00
MHDA- 2013/12/16 06:00
CRDT- 2011/05/06 06:00
PHST- 2011/02/09 00:00 [received]
PHST- 2011/04/21 00:00 [accepted]
PHST- 2011/05/06 06:00 [entrez]
PHST- 2011/05/06 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1007/s11948-011-9278-y [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2012 Dec;18(4):633-50. doi: 10.1007/s11948-011-9278-y. Epub 2011 
      May 5.


PMID- 21544679
OWN - NLM
STAT- MEDLINE
DCOM- 20120206
LR  - 20211020
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 23
IP  - 3
DP  - 2011 Sep
TI  - The functioning of hospital ethics committees: a multiple-case study of four
      Canadian committees.
PG  - 225-38
LID - 10.1007/s10730-011-9151-z [doi]
AB  - A multiple-case study of four hospital ethics committees in Canada was conducted 
      and data collected included interviews with key informants, observation of
      committee meetings and ethics-related hospital documents, such as policies and
      committee minutes. We compared the hospital committees in terms of their
      structure, functioning and perceptions of key informants and found variation in
      the dimensions of empowerment, organizational culture of ethics, breadth of
      ethics mandate, achievements, dynamism, and expertise.
FAU - Gaudine, Alice
AU  - Gaudine A
AD  - School of Nursing, Memorial University of Newfoundland, St. John's, Newfoundland,
      Canada. agaudine@mun.ca
FAU - Lamb, Marianne
AU  - Lamb M
FAU - Lefort, Sandra M
AU  - Lefort SM
FAU - Thorne, Linda
AU  - Thorne L
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - Canada
MH  - Ethics Committees, Clinical/*organization & administration
MH  - Humans
MH  - Organizational Culture
MH  - Power, Psychological
MH  - Professional Competence
MH  - *Professional Role
MH  - Qualitative Research
EDAT- 2011/05/06 06:00
MHDA- 2012/02/07 06:00
CRDT- 2011/05/06 06:00
PHST- 2011/05/06 06:00 [entrez]
PHST- 2011/05/06 06:00 [pubmed]
PHST- 2012/02/07 06:00 [medline]
AID - 10.1007/s10730-011-9151-z [doi]
PST - ppublish
SO  - HEC Forum. 2011 Sep;23(3):225-38. doi: 10.1007/s10730-011-9151-z.


PMID- 21543989
OWN - NLM
STAT- MEDLINE
DCOM- 20110928
LR  - 20220210
IS  - 1530-0366 (Electronic)
IS  - 1098-3600 (Linking)
VI  - 13
IP  - 6
DP  - 2011 Jun
TI  - Implementation outcomes of a multiinstitutional web-based ethical, legal, and
      social implications genetics curriculum for primary care residents in three
      specialties.
PG  - 553-62
LID - 10.1097/GIM.0b013e31820e279a [doi]
AB  - PURPOSE: Medical genetics lends itself to disseminated teaching methods because
      of mismatches between numbers of physicians having patients with genetic
      disorders and availability of genetic specialists. METHOD: During 3 years, we
      implemented an interactive, web-based curriculum on ethical, legal, and social
      implications in medical genetics for primary care residents in three specialties 
      at three institutions. Residents took five (of 10) cases and three (of five)
      tutorials that varied by specialty. We assessed changes in self-efficacy (primary
      outcome), knowledge, application, and viewpoints. RESULTS: Overall enrollment was
      69% (279/403). One institution did not complete implementation and was dropped
      from pre-post comparisons. We developed a six-factor ethical, legal, and social
      implications self-efficacy scale (Cronbach alpha = 0.95). Baseline self-efficacy 
      was moderate (71/115; range: 23-115) and increased 15% after participation.
      Pre-post knowledge scores were high and unchanged. Residents reported that this
      curriculum covered ethical, legal, and social implications/genetics better than
      their usual curricula. Most (68-91%) identified advantages, especially in
      providing flexibility and stimulating self-directed learning. After
      participation, residents reported creating learning goals (66%) and acting on
      those goals (62%). CONCLUSIONS: Ethical, legal, and social implications genetics 
      curricular participation led to modest self-efficacy gains. Residents reported
      that the curriculum covered unique content areas, had advantages over traditional
      curriculum, and that they applied ethical, legal, and social implications content
      clinically. We share lessons from developing and implementing this complex
      web-based curriculum across multiple institutions.
FAU - Srinivasan, Malathi
AU  - Srinivasan M
AD  - Department of Medicine, University of California Davis, School of Medicine,
      Sacramento, California 95833, USA. malathi@ucdavis.edu
FAU - Day, Frank C
AU  - Day FC
FAU - Griffin, Erin
AU  - Griffin E
FAU - Tancredi, Daniel J
AU  - Tancredi DJ
FAU - Burke, Wylie
AU  - Burke W
FAU - Pinsky, Linda
AU  - Pinsky L
FAU - Pagon, Roberta A
AU  - Pagon RA
FAU - Hoffman, Jerome R
AU  - Hoffman JR
FAU - Wilkes, Michael S
AU  - Wilkes MS
LA  - eng
GR  - R25-HG002903/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genet Med
JT  - Genetics in medicine : official journal of the American College of Medical
      Genetics
JID - 9815831
SB  - IM
MH  - Education, Medical, Graduate/*standards
MH  - Genetics, Medical/*education/ethics/legislation & jurisprudence
MH  - Humans
MH  - *Internet
MH  - *Internship and Residency
MH  - *Primary Health Care
MH  - Workforce
EDAT- 2011/05/06 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/05/06 06:00
PHST- 2011/05/06 06:00 [entrez]
PHST- 2011/05/06 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 10.1097/GIM.0b013e31820e279a [doi]
AID - S1098-3600(21)04805-X [pii]
PST - ppublish
SO  - Genet Med. 2011 Jun;13(6):553-62. doi: 10.1097/GIM.0b013e31820e279a.


PMID- 21543248
OWN - NLM
STAT- MEDLINE
DCOM- 20120201
LR  - 20111010
IS  - 1887-1364 (Electronic)
IS  - 1134-282X (Linking)
VI  - 26
IP  - 5
DP  - 2011 Sep-Oct
TI  - [Conscientious objection in the clinical setting. A proposal for its appropriate 
      use (II)].
PG  - 320-4
LID - 10.1016/j.cali.2011.02.007 [doi]
AB  - Social changes and new technologies have brought new problems in doctor-patient
      relationship. In many clinical contexts conscientious objection is misused, with 
      negative effects for patients, healthcare professionals and institutions. In this
      article an attempt will be made to clarify the problem from a clinical point of
      view, assessing the increase in risks in clinical praxis due to patient choice,
      the complexity of current clinical praxis, and the appropriate use of life
      support measures. Likewise, it analyses socially controversial ethical values and
      professional practices with no curative value and with no clinical indication in 
      the physiological sense.
CI  - Copyright (c) 2011 SECA. Published by Elsevier Espana. All rights reserved.
FAU - Couceiro, A
AU  - Couceiro A
AD  - Facultad de Medicina (UPV/EHU), Bilbao, Bizcaia, Espana. acouceiro@arrakis.es
FAU - Seoane, J A
AU  - Seoane JA
FAU - Hernando, P
AU  - Hernando P
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - La objecion de conciencia en el ambito clinico. Propuesta para un uso apropiado
      (II).
DEP - 20110502
PL  - Spain
TA  - Rev Calid Asist
JT  - Revista de calidad asistencial : organo de la Sociedad Espanola de Calidad
      Asistencial
JID - 9601664
SB  - IM
MH  - Conscience
MH  - Humans
MH  - Life Support Care/ethics
MH  - Medical Futility
MH  - Patient Participation
MH  - *Refusal to Treat/ethics
EDAT- 2011/05/06 06:00
MHDA- 2012/02/02 06:00
CRDT- 2011/05/06 06:00
PHST- 2011/02/23 00:00 [received]
PHST- 2011/02/23 00:00 [accepted]
PHST- 2011/05/06 06:00 [entrez]
PHST- 2011/05/06 06:00 [pubmed]
PHST- 2012/02/02 06:00 [medline]
AID - S1134-282X(11)00042-X [pii]
AID - 10.1016/j.cali.2011.02.007 [doi]
PST - ppublish
SO  - Rev Calid Asist. 2011 Sep-Oct;26(5):320-4. doi: 10.1016/j.cali.2011.02.007. Epub 
      2011 May 2.


PMID- 21543247
OWN - NLM
STAT- MEDLINE
DCOM- 20110909
LR  - 20110517
IS  - 1887-1364 (Electronic)
IS  - 1134-282X (Linking)
VI  - 26
IP  - 3
DP  - 2011 May-Jun
TI  - [Conscientious objection in the clinical setting. A proposal for its appropriate 
      use].
PG  - 188-93
LID - 10.1016/j.cali.2011.02.008 [doi]
AB  - Social changes and new technologies have brought new problems in doctor-patient
      relationships. In many clinical contexts conscientious objection is misused, with
      negative effects for patients, healthcare professionals and institutions. The
      paper aims to clarify what conscientious objection means in a plural society
      based on a deliberative democracy and to show the different ways of understanding
      this society in order to respect both the ethical reasons of individuals and the 
      compulsory normative framework of the Rule of Law. Furthermore, the paper
      identifies some clinical settings where conscientious objection is often invoked 
      by healthcare professionals, and points out and analyses the arguments that
      explain why this appeal for conscientious objection is neither legitimate nor
      correct. Finally, it provides examples of the legal basis and Spanish
      jurisprudence, as well as the relevant clinical and ethical literature on this
      topic.
CI  - Copyright (c) 2011 SECA. Published by Elsevier Espana. All rights reserved.
FAU - Couceiro, A
AU  - Couceiro A
AD  - Facultad de Medicina (UPV/EHU), Bilbao, Bizcaia, Espana. acouceiro@arrakis.es
FAU - Seoane, J A
AU  - Seoane JA
FAU - Hernando, P
AU  - Hernando P
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - La objecion de conciencia en el ambito clinico. Propuesta para un uso apropiado. 
      I.
DEP - 20110502
PL  - Spain
TA  - Rev Calid Asist
JT  - Revista de calidad asistencial : organo de la Sociedad Espanola de Calidad
      Asistencial
JID - 9601664
SB  - IM
MH  - *Conscience
MH  - Decision Making/ethics
MH  - Democracy
MH  - Dissent and Disputes
MH  - Human Rights/*legislation & jurisprudence
MH  - Humans
MH  - Mental Competency
MH  - Moral Obligations
MH  - Patient Rights/legislation & jurisprudence
MH  - Personal Autonomy
MH  - Physician-Patient Relations/ethics
MH  - Professional Autonomy
MH  - Professional Practice/ethics/*legislation & jurisprudence
MH  - Refusal to Treat/ethics/*legislation & jurisprudence
MH  - Social Values
MH  - Spain
MH  - Terminal Care/*ethics/legislation & jurisprudence
MH  - Treatment Refusal/*ethics/legislation & jurisprudence
MH  - Withholding Treatment/ethics/legislation & jurisprudence
EDAT- 2011/05/06 06:00
MHDA- 2011/09/10 06:00
CRDT- 2011/05/06 06:00
PHST- 2011/02/05 00:00 [received]
PHST- 2011/02/22 00:00 [revised]
PHST- 2011/02/23 00:00 [accepted]
PHST- 2011/05/06 06:00 [entrez]
PHST- 2011/05/06 06:00 [pubmed]
PHST- 2011/09/10 06:00 [medline]
AID - S1134-282X(11)00043-1 [pii]
AID - 10.1016/j.cali.2011.02.008 [doi]
PST - ppublish
SO  - Rev Calid Asist. 2011 May-Jun;26(3):188-93. doi: 10.1016/j.cali.2011.02.008. Epub
      2011 May 2.


PMID- 21542889
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1756-994X (Electronic)
IS  - 1756-994X (Linking)
VI  - 3
IP  - 4
DP  - 2011 Apr 27
TI  - Methods for the de-identification of electronic health records for genomic
      research.
PG  - 25
LID - 10.1186/gm239 [doi]
AB  - Electronic health records are increasingly being linked to DNA repositories and
      used as a source of clinical information for genomic research. Privacy
      legislation in many jurisdictions, and most research ethics boards, require that 
      either personal health information is de-identified or that patient consent or
      authorization is sought before the data are disclosed for secondary purposes.
      Here, I discuss how de-identification has been applied in current genomic
      research projects. Recent metrics and methods that can be used to ensure that the
      risk of re-identification is low and that disclosures are compliant with privacy 
      legislation and regulations (such as the Health Insurance Portability and
      Accountability Act Privacy Rule) are reviewed. Although these methods can protect
      against the known approaches for re-identification, residual risks and specific
      challenges for genomic research are also discussed.
FAU - El Emam, Khaled
AU  - El Emam K
AD  - Children's Hospital of Eastern Ontario Research Institute, 401 Smyth Road,
      Ottawa, Ontario K1J 8L1, Canada. kelemam@uottawa.ca.
LA  - eng
PT  - Journal Article
DEP - 20110427
PL  - England
TA  - Genome Med
JT  - Genome medicine
JID - 101475844
PMC - PMC3129641
EDAT- 2011/05/06 06:00
MHDA- 2011/05/06 06:01
CRDT- 2011/05/06 06:00
PHST- 2011/05/06 06:00 [entrez]
PHST- 2011/05/06 06:00 [pubmed]
PHST- 2011/05/06 06:01 [medline]
AID - gm239 [pii]
AID - 10.1186/gm239 [doi]
PST - epublish
SO  - Genome Med. 2011 Apr 27;3(4):25. doi: 10.1186/gm239.


PMID- 21542880
OWN - NLM
STAT- MEDLINE
DCOM- 20120127
LR  - 20211020
IS  - 1466-609X (Electronic)
IS  - 1364-8535 (Linking)
VI  - 15
IP  - 2
DP  - 2011
TI  - European legislation impedes critical care research and fails to protect
      patients' rights.
PG  - 148
LID - 10.1186/cc10113 [doi]
AB  - The European Clinical Trials Directive requires an informed consent from the
      patient or a proxy in drug trials. Although informed consent is a valuable tool
      to protect patients' rights in clinical trials, this requirement largely impedes 
      research in critical care settings, and if pursued in this context, it does not
      provide the patient with adequate protection. Instead of insisting on informed
      consent, we suggest that the focus should be shifted towards two other ethically 
      relevant elements in human experimentation: risk assessment and selection of
      research subjects. When reviewing protocols in which a waiver of consent is
      deemed necessary, the Ethical Review Board should ensure that non-therapeutic
      risks are minimal, that the research is specifically designed to benefit
      critically ill patients, and that it cannot be conducted under circumstances
      where an informed consent can be obtained. If the European Directive is changed
      accordingly, this permits clinical trials in critical care settings, while
      adequate protection from risky non-therapeutic procedures is ensured and
      exploitation of the patient as an easily accessible research subject is
      prevented.
FAU - Berg, Ronan M G
AU  - Berg RM
AD  - Centre of Inflammation and Metabolism, Department of Infectious Diseases,
      Rigshospitalet, 2100 Copenhagen O, Denmark. ronan@dadlnet.dk
FAU - Moller, Kirsten
AU  - Moller K
FAU - Rossel, Peter J Hancke
AU  - Rossel PJ
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20110414
PL  - England
TA  - Crit Care
JT  - Critical care (London, England)
JID - 9801902
SB  - IM
CON - Crit Care. 2004 Apr;8(2):85-6. PMID: 15025761
MH  - Biomedical Research/*ethics
MH  - Critical Care/*ethics
MH  - Humans
MH  - Intensive Care Units/*ethics
MH  - *Risk Assessment
PMC - PMC3219370
EDAT- 2011/05/06 06:00
MHDA- 2012/01/28 06:00
CRDT- 2011/05/06 06:00
PHST- 2011/05/06 06:00 [entrez]
PHST- 2011/05/06 06:00 [pubmed]
PHST- 2012/01/28 06:00 [medline]
AID - cc10113 [pii]
AID - 10.1186/cc10113 [doi]
PST - ppublish
SO  - Crit Care. 2011;15(2):148. doi: 10.1186/cc10113. Epub 2011 Apr 14.


PMID- 21542261
OWN - NLM
STAT- MEDLINE
DCOM- 20110621
LR  - 20110504
IS  - 0253-0465 (Print)
IS  - 0253-0465 (Linking)
VI  - 104
IP  - 4
DP  - 2011
TI  - [Settimio Monteverde. "There is no ethics free space" (interview by Urs Luthi)].
PG  - 32-3
FAU - Monteverde, Settimio
AU  - Monteverde S
LA  - ger
PT  - Interview
TT  - Settimio Monteverde. "Es gibt keinen ethikfreien Raum".
PL  - Switzerland
TA  - Krankenpfl Soins Infirm
JT  - Krankenpflege. Soins infirmiers
JID - 8000153
MH  - Cost-Benefit Analysis
MH  - *Ethics, Nursing
MH  - Humans
MH  - National Health Programs/*economics/*ethics
MH  - Palliative Care/*economics/*ethics
MH  - Pastoral Care/*economics/*ethics
MH  - Switzerland
EDAT- 2011/05/06 06:00
MHDA- 2011/06/22 06:00
CRDT- 2011/05/06 06:00
PHST- 2011/05/06 06:00 [entrez]
PHST- 2011/05/06 06:00 [pubmed]
PHST- 2011/06/22 06:00 [medline]
PST - ppublish
SO  - Krankenpfl Soins Infirm. 2011;104(4):32-3.


PMID- 21541860
OWN - NLM
STAT- MEDLINE
DCOM- 20110801
LR  - 20151119
IS  - 1543-6136 (Electronic)
IS  - 1381-1118 (Linking)
VI  - 15
IP  - 2
DP  - 2011
TI  - Screening for suicidality in the emergency department: when must researchers act 
      to protect subjects' interests?
PG  - 140-50
LID - 10.1080/13811118.2011.565271 [doi]
AB  - The emergency department (ED) is a key site in preventing suicide. Yet there has 
      been very little research on ED screening and interventions targeting the
      suicidal patient. Conducting research on interventions for preventing suicidal
      behavior in the ED population may evoke the dilemma of how to fulfill ethical
      obligations to protect research subjects when doing so can impair the validity of
      the study. In this paper we present a case study of a research protocol on the
      utility of routine screening with a brief intervention for suicidal ideation that
      raised issues regarding researchers' obligation to disclose information about
      subjects' suicidality to ED staff. After exploring the imperfect relationship
      between suicidal ideation and completed suicide (i.e., many people with ideation 
      never attempt or commit suicide), we present an analysis of the causal
      relationship between these phenomena. This leads us to suggest that it should not
      be mandatory for researchers to disclose to ED staff when a subject reveals
      suicide ideation in a screening questionnaire-although other preventive measures 
      may be called for. In general, the extent of the duty placed on researchers to
      intervene on behalf of their subjects should be proportional to the likelihood
      and magnitude of risk presented to subjects by the underlying condition, and
      should be balanced against the importance of the research question.
FAU - Gold, Azgad
AU  - Gold A
AD  - Department of Psychiatry, Columbia University College of Physicians and Surgeons,
      New York, New York 10032, USA. atg2119@columbia.edu
FAU - Appelbaum, Paul S
AU  - Appelbaum PS
FAU - Stanley, Barbara
AU  - Stanley B
LA  - eng
PT  - Journal Article
PL  - England
TA  - Arch Suicide Res
JT  - Archives of suicide research : official journal of the International Academy for 
      Suicide Research
JID - 9504451
SB  - IM
MH  - Confidentiality
MH  - *Emergency Service, Hospital
MH  - *Ethics, Research
MH  - Female
MH  - Humans
MH  - Male
MH  - *Mass Screening
MH  - Moral Obligations
MH  - Research Personnel/ethics
MH  - Research Subjects
MH  - Researcher-Subject Relations/ethics
MH  - Suicide/*prevention & control
MH  - Surveys and Questionnaires
EDAT- 2011/05/05 06:00
MHDA- 2011/08/02 06:00
CRDT- 2011/05/05 06:00
PHST- 2011/05/05 06:00 [entrez]
PHST- 2011/05/05 06:00 [pubmed]
PHST- 2011/08/02 06:00 [medline]
AID - 937133959 [pii]
AID - 10.1080/13811118.2011.565271 [doi]
PST - ppublish
SO  - Arch Suicide Res. 2011;15(2):140-50. doi: 10.1080/13811118.2011.565271.


PMID- 21541791
OWN - NLM
STAT- MEDLINE
DCOM- 20111031
LR  - 20110614
IS  - 1573-2800 (Electronic)
IS  - 0004-0002 (Linking)
VI  - 40
IP  - 4
DP  - 2011 Aug
TI  - Theoretical issues in the study of asexuality.
PG  - 713-23
LID - 10.1007/s10508-011-9757-x [doi]
AB  - Academic interest in asexual people is new and researchers are beginning to
      discuss how to proceed methodologically and conceptually with the study of
      asexuality. This article explores several of the theoretical issues related to
      the study of asexuality. Researchers have tended to treat asexuality either as a 
      distinct sexual orientation or as a lack of sexual orientation. Difficulties
      arise when asexual participants are inconsistent in their self-identification as 
      asexual. Distinguishing between sexual and romantic attraction resolves this
      confusion, while simultaneously calling into question conceptualizations of the
      asexual population as a single homogenous group. Arguments are considered in
      favor of exploring diversity within the asexual population, particularly with
      respect to gender and romantic orientation, proposing that the categorical
      constructs employed in (a)sexuality research be replaced with continuous ones.
      Furthermore, given the recently noted bias toward including only self-identified 
      asexuals, as opposed to non-self-identified asexuals or "potential-asexuals," in 
      research about asexuality, the nature and meaning of asexual self-identification 
      are discussed. Particular attention is paid to the theoretical importance of
      acknowledging asexual self-identification or lack thereof in future research into
      asexuality. This article discusses what these current theoretical issues mean for
      the study of asexuality and sexuality more generally, including a brief
      consideration of ethical implications for research with asexual participants.
      Finally, directions for future research are suggested.
FAU - DeLuzio Chasin, C J
AU  - DeLuzio Chasin CJ
AD  - Department of Psychology, University of Windsor, Windsor, ON, N9B 3P4, Canada.
      chasin@uwindsor.ca
LA  - eng
PT  - Journal Article
DEP - 20110504
PL  - United States
TA  - Arch Sex Behav
JT  - Archives of sexual behavior
JID - 1273516
SB  - IM
MH  - Female
MH  - Humans
MH  - *Libido
MH  - Male
MH  - *Research
MH  - *Sexual Behavior
EDAT- 2011/05/05 06:00
MHDA- 2011/11/01 06:00
CRDT- 2011/05/05 06:00
PHST- 2009/10/30 00:00 [received]
PHST- 2011/02/12 00:00 [accepted]
PHST- 2010/07/31 00:00 [revised]
PHST- 2011/05/05 06:00 [entrez]
PHST- 2011/05/05 06:00 [pubmed]
PHST- 2011/11/01 06:00 [medline]
AID - 10.1007/s10508-011-9757-x [doi]
PST - ppublish
SO  - Arch Sex Behav. 2011 Aug;40(4):713-23. doi: 10.1007/s10508-011-9757-x. Epub 2011 
      May 4.


PMID- 21541083
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 2042-5333 (Electronic)
IS  - 2042-5333 (Linking)
VI  - 2
IP  - 3
DP  - 2011 Mar 14
TI  - The correlation of anxiety and depression levels with response to neoadjuvant
      chemotherapy in patients with breast cancer.
PG  - 15
LID - 10.1258/shorts.2010.010072 [doi]
AB  - BACKGROUND: The aim was to evaluate and correlate anxiety and depression levels
      with response to neoadjuvant chemotherapy in patients with breast cancer. The
      study also assessed the effects of family support on distress levels. DESIGN: It 
      was a prospective study in a cohort of 84 patients with locally advanced breast
      cancer. These assessments were done using the Hospital Anxiety and Depression
      Scale (HADS). SETTING: A prospective study in a developing world setting.
      PARTICIPANTS: Eighty-four patients with locally advanced breast cancer receiving 
      neoadjuvant chemotherapy were included after taking an informed consent and
      ethical committee clearance. MAIN OUTCOME MEASURES: A significant correlation was
      observed between response to neoadjuvant chemotherapy and depression levels in
      breast cancer patients. Joint family and literacy levels also had an impact on
      the levels of depression observed. RESULTS: A total of 84 patients receiving
      neoadjuvant chemotherapy for breast cancer were evaluated using HADS. The effect 
      of family support, literacy levels and employment on the psychological status of 
      these patients were also assessed. CONCLUSIONS: The response to neoadjuvant
      chemotherapy had a direct correlation with the levels of depression, the distress
      levels being lower in responders. This was found to be the most important
      variable determining the psychological status of the patients. It was also
      observed that Indian patients in comparison to their Western counterparts react
      differently to cancer-related stress.
FAU - Chintamani
AU  - Chintamani
AD  - VMMC, Safdarjang Hospital New Delhi - Surgery , New Delhi.
FAU - Gogne, Anupriya
AU  - Gogne A
FAU - Khandelwal, Rohan
AU  - Khandelwal R
FAU - Tandon, Megha
AU  - Tandon M
FAU - Jain, Sidharth
AU  - Jain S
FAU - Kumar, Yashwant
AU  - Kumar Y
FAU - Narayan, Nikhil
AU  - Narayan N
FAU - Bamal, Rahul
AU  - Bamal R
FAU - Srinivas, S
AU  - Srinivas S
FAU - Saxena, Sunita
AU  - Saxena S
LA  - eng
PT  - Journal Article
DEP - 20110314
PL  - England
TA  - JRSM Short Rep
JT  - JRSM short reports
JID - 101536254
PMC - PMC3086323
EDAT- 2011/05/05 06:00
MHDA- 2011/05/05 06:01
CRDT- 2011/05/05 06:00
PHST- 2011/05/05 06:00 [entrez]
PHST- 2011/05/05 06:00 [pubmed]
PHST- 2011/05/05 06:01 [medline]
AID - 10.1258/shorts.2010.010072 [doi]
PST - epublish
SO  - JRSM Short Rep. 2011 Mar 14;2(3):15. doi: 10.1258/shorts.2010.010072.


PMID- 21540683
OWN - NLM
STAT- MEDLINE
DCOM- 20110919
LR  - 20110504
IS  - 1550-5073 (Electronic)
IS  - 0893-2190 (Linking)
VI  - 25
IP  - 2
DP  - 2011 Apr-Jun
TI  - Redirecting treatment during neonatal transport.
PG  - 111-4
LID - 10.1097/JPN.0b013e31821a20ab [doi]
AB  - Neonatal transport teams comprise multidisciplinary health care providers who are
      skilled in patient care, communication and customer service, and equipment
      mechanics. They are extensively trained in resuscitation and stabilization,
      preparing for accelerating care, and their focus is preservation of life. In any 
      situation focused on caring for critically ill patients, ethical issues and
      questions may arise. For instance, is it compassionate and/or cost-effective to
      separate mothers and infants when continuing/accelerating care is futile, and
      when and how should care be redirected from acute and lifesaving care to comfort 
      care and bereavement support for the family? The knowledge and skills required to
      address such situations and communicate and participate in a redirection of care 
      may not be adequately emphasized in the preparation of the professionals
      responsible for stabilizing and transporting critically ill newborns. This
      article raises issues relating to transport and redirecting care such as
      eligibility for transport, parental request and consent, separation of mothers
      and infants, palliative and bereavement care, ethical considerations, competitive
      transport environment, and customer service. A shared mental model is essential. 
      The focus of this article is not to provide answers to all of these issues, but
      to highlight the complexity of the topic of redirecting treatment during neonatal
      transport. Redirecting treatment needs to be discussed, and health care
      professionals should be prepared during their transport team training. Each
      family and situation must be approached individually, with the acceptance that
      there will always be more questions than answers.
FAU - Dulkerian, Susan J
AU  - Dulkerian SJ
AD  - Department of Pediatrics, University of Maryland Hospital for Children,
      Baltimore, MD, USA. Sdulkerian@mdmercy.com
FAU - Douglas, Webra Price
AU  - Douglas WP
FAU - Taylor, Renee McCraine
AU  - Taylor RM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Perinat Neonatal Nurs
JT  - The Journal of perinatal & neonatal nursing
JID - 8801387
MH  - Academic Medical Centers
MH  - Critical Illness/mortality/therapy
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Newborn, Diseases/mortality/*therapy
MH  - Informed Consent
MH  - Interdisciplinary Communication
MH  - Male
MH  - Parental Consent
MH  - Patient Care Team/*organization & administration
MH  - Patient Transfer/*organization & administration
MH  - *Referral and Consultation
MH  - Risk Assessment
MH  - Survival Rate
MH  - Total Quality Management
EDAT- 2011/05/05 06:00
MHDA- 2011/09/20 06:00
CRDT- 2011/05/05 06:00
PHST- 2011/05/05 06:00 [entrez]
PHST- 2011/05/05 06:00 [pubmed]
PHST- 2011/09/20 06:00 [medline]
AID - 10.1097/JPN.0b013e31821a20ab [doi]
AID - 00005237-201104000-00006 [pii]
PST - ppublish
SO  - J Perinat Neonatal Nurs. 2011 Apr-Jun;25(2):111-4. doi:
      10.1097/JPN.0b013e31821a20ab.


PMID- 21540253
OWN - NLM
STAT- MEDLINE
DCOM- 20120705
LR  - 20120308
IS  - 1461-7196 (Electronic)
IS  - 1363-4593 (Linking)
VI  - 16
IP  - 2
DP  - 2012 Mar
TI  - Network gatekeeping: complementary medicine information on the websites of
      medical institutions.
PG  - 151-68
LID - 10.1177/1363459311403950 [doi]
AB  - Integrative medicine - complementary and alternative medicine (CAM) practised in 
      mainstream healthcare organizations - combines medical treatments based on
      incommensurable paradigms. As the Internet has been portrayed as a crucial
      pathway to CAM and sites administered by reputable organizations are considered
      to be relatively reliable sources of medical information, the research sought to 
      explore and compare the ways in which CAM is presented on the Internet websites
      of diverse medical institutions. The contents of the websites of the Ministry of 
      Health, the Israeli Medical Association and Israeli healthcare organizations were
      analysed, using an interdisciplinary theory of network gatekeeping. The websites 
      were analysed not only according to the degree to which they are considered to be
      informative, but also with regard to the perceptions of integration that they
      convey. Comparison of the websites of community healthcare organizations and
      hospitals indicates that while the former display CAM treatments as an attractive
      commodity, the latter convey a message stressing the need to subject CAM to
      bio-medical scrutiny. Little or no information was provided concerning a number
      of important issues, such as research findings about efficacy and safety, risks
      and ethical considerations.
FAU - Keshet, Yael
AU  - Keshet Y
AD  - Western Galilee Academic College, Israel. yaelk@wgalil.ac.il
LA  - eng
PT  - Journal Article
DEP - 20110503
PL  - England
TA  - Health (London)
JT  - Health (London, England : 1997)
JID - 9800465
SB  - IM
MH  - Complementary Therapies/*statistics & numerical data
MH  - Consumer Health Information/*methods
MH  - Health Services Administration/*statistics & numerical data
MH  - Humans
MH  - Internet/*statistics & numerical data
MH  - Israel
EDAT- 2011/05/05 06:00
MHDA- 2012/07/06 06:00
CRDT- 2011/05/05 06:00
PHST- 2011/05/05 06:00 [entrez]
PHST- 2011/05/05 06:00 [pubmed]
PHST- 2012/07/06 06:00 [medline]
AID - 1363459311403950 [pii]
AID - 10.1177/1363459311403950 [doi]
PST - ppublish
SO  - Health (London). 2012 Mar;16(2):151-68. doi: 10.1177/1363459311403950. Epub 2011 
      May 3.


PMID- 21539618
OWN - NLM
STAT- MEDLINE
DCOM- 20120105
LR  - 20110622
IS  - 1600-0625 (Electronic)
IS  - 0906-6705 (Linking)
VI  - 20
IP  - 7
DP  - 2011 Jul
TI  - Clinical application of multiphoton tomography in combination with confocal laser
      scanning microscopy for in vivo evaluation of skin diseases.
PG  - 589-94
LID - 10.1111/j.1600-0625.2011.01279.x [doi]
AB  - Multiphoton tomography (MPT) is an in vivo imaging technique with very high
      spatial resolution and efforts are made to combine MPT with other non-invasive
      imaging methods. The goals of the present study were the description of the
      features of different dermatological entities as seen in MPT and confocal laser
      scanning microscopy (CLSM) comparison of these two novel techniques and the
      'classical' diagnostic measures visual inspection, dermoscopy and histology with 
      respect to the strengths and weaknesses of the different methods and the
      potential benefit from their combined implementation. After study approval by the
      local Ethics Committee, 47 patients (31 male, 16 female, age range: 24-88 years) 
      were recruited from the Department of Dermatology of the University Hospital
      Jena. In this work, we present an illustrative selection of eleven cases from a
      clinical study combining in vivo MPT with in vivo CLSM. The patients presented
      with a broad range of dermatological disorders including seborrheic keratoses,
      angioma, actinic keratoses, melanocytic nevi, malignant melanoma, psoriasis,
      pemphigus vulgaris and scarring. Both methods, CLSM and MPT, were found to be
      suitable for in vivo imaging of superficial skin layers and may therefore be
      useful in dermatological practice for the diagnosis of skin diseases. However,
      both methods differ in their technical and physical principles. Thus, despite of 
      many similarities concerning the morphological presentation of cells and tissues,
      important differences are recognized. Synergies of the combination of CLSM and
      MPT may be obtained by combined implementation in order to benefit from the fast 
      overview given by CLSM and the detailed imaging of skin structures by MPT.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Koehler, Martin Johannes
AU  - Koehler MJ
AD  - Department of Dermatology, University Hospital Jena, Jena, Germany.
      johannes.koehler@med.uni-jena.de
FAU - Speicher, Marco
AU  - Speicher M
FAU - Lange-Asschenfeldt, Susanne
AU  - Lange-Asschenfeldt S
FAU - Stockfleth, Eggert
AU  - Stockfleth E
FAU - Metz, Susanne
AU  - Metz S
FAU - Elsner, Peter
AU  - Elsner P
FAU - Kaatz, Martin
AU  - Kaatz M
FAU - Konig, Karsten
AU  - Konig K
LA  - eng
PT  - Journal Article
DEP - 20110504
PL  - Denmark
TA  - Exp Dermatol
JT  - Experimental dermatology
JID - 9301549
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cicatrix/diagnosis/pathology
MH  - Dermis/pathology
MH  - Epidermis/pathology
MH  - Female
MH  - Hemangioma/diagnosis/pathology
MH  - Humans
MH  - Keratosis, Actinic/diagnosis/pathology
MH  - Keratosis, Seborrheic/diagnosis/pathology
MH  - Male
MH  - Melanoma/diagnosis/pathology
MH  - Microscopy, Confocal/methods
MH  - Middle Aged
MH  - Nevus, Pigmented/diagnosis/pathology
MH  - Pemphigus/diagnosis/pathology
MH  - Psoriasis/diagnosis/pathology
MH  - Skin Diseases/diagnosis/*pathology
MH  - Tomography/*methods
MH  - Young Adult
EDAT- 2011/05/05 06:00
MHDA- 2012/01/06 06:00
CRDT- 2011/05/05 06:00
PHST- 2011/05/05 06:00 [entrez]
PHST- 2011/05/05 06:00 [pubmed]
PHST- 2012/01/06 06:00 [medline]
AID - 10.1111/j.1600-0625.2011.01279.x [doi]
PST - ppublish
SO  - Exp Dermatol. 2011 Jul;20(7):589-94. doi: 10.1111/j.1600-0625.2011.01279.x. Epub 
      2011 May 4.


PMID- 21539461
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20110526
IS  - 1545-0066 (Electronic)
IS  - 1090-3127 (Linking)
VI  - 15
IP  - 3
DP  - 2011 Jul-Sep
TI  - Expert witness qualifications and ethical guidelines for emergency medical
      services litigation: resource document for the National Association of EMS
      Physicians position statement.
PG  - 426-31
LID - 10.3109/10903127.2011.561413 [doi]
AB  - The clinical provision of medical care by emergency medical services (EMS)
      providers in the out-of-hospital environment and the operation of EMS systems to 
      provide that care are unique in the medical arena. There is a substantive
      difference in the experience of individuals who provide medical care in the
      out-of-hospital setting and the experience of those who provide similar care in
      the hospital or other clinical settings. Furthermore, physicians who provide
      medical direction for EMS personnel have a clinical and oversight relationship
      with EMS personnel. This relationship uniquely qualifies EMS medical directors to
      provide expert opinions related to care provided by nonphysician EMS personnel.
      Physicians without specific EMS oversight experience are not uniformly qualified 
      to provide expert opinion regarding the provision of EMS. This resource document 
      reviews the current issues in expert witness testimony in cases involving EMS as 
      these issues relate to the unique qualifications of the expert witness, the
      standard of care, and the ethical expectations.
FAU - Maggiore, W Ann Winnie
AU  - Maggiore WA
AD  - Department of Emergency Medicine, University of New Mexico Hospital, Albuquerque,
      New Mexico, USA.
FAU - Kupas, Douglas F
AU  - Kupas DF
FAU - Glushak, Cai
AU  - Glushak C
CN  - National Association of EMS Physicians
LA  - eng
PT  - Journal Article
DEP - 20110503
PL  - England
TA  - Prehosp Emerg Care
JT  - Prehospital emergency care
JID - 9703530
SB  - IM
MH  - Clinical Competence
MH  - Emergency Medicine/*ethics/legislation & jurisprudence
MH  - Emergency Service, Hospital/*ethics/legislation & jurisprudence
MH  - *Ethics, Medical
MH  - Expert Testimony/ethics/*legislation & jurisprudence
MH  - *Guidelines as Topic
MH  - Humans
MH  - *Jurisprudence
MH  - Liability, Legal
MH  - Malpractice/*legislation & jurisprudence
MH  - United States
EDAT- 2011/05/05 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/05/05 06:00
PHST- 2011/05/05 06:00 [entrez]
PHST- 2011/05/05 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 10.3109/10903127.2011.561413 [doi]
PST - ppublish
SO  - Prehosp Emerg Care. 2011 Jul-Sep;15(3):426-31. doi: 10.3109/10903127.2011.561413.
      Epub 2011 May 3.


PMID- 21539178
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20110504
IS  - 8756-8160 (Print)
IS  - 8756-8160 (Linking)
VI  - 26
IP  - 3
DP  - 2011 Spring
TI  - Other people's lives: reflections on medicine, ethics, and euthanasia. Part two: 
      medicine versus euthanasia.
PG  - 239-79
FAU - Fenigsen, Richard
AU  - Fenigsen R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Issues Law Med
JT  - Issues in law & medicine
JID - 8511295
SB  - IM
MH  - Chronic Disease
MH  - Family
MH  - Humans
MH  - Pain/prevention & control
MH  - Physician's Role
MH  - Suicide, Assisted/*ethics
EDAT- 2011/05/05 06:00
MHDA- 2011/06/29 06:00
CRDT- 2011/05/05 06:00
PHST- 2011/05/05 06:00 [entrez]
PHST- 2011/05/05 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
PST - ppublish
SO  - Issues Law Med. 2011 Spring;26(3):239-79.


PMID- 21538435
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20110727
IS  - 1527-3350 (Electronic)
IS  - 0270-9139 (Linking)
VI  - 54
IP  - 2
DP  - 2011 Aug
TI  - The ethics of placebo treatment for patients with acute exacerbation of chronic
      hepatitis B.
PG  - 740; author reply 741-2
LID - 10.1002/hep.24392 [doi]
FAU - Lo, Gin-Ho
AU  - Lo GH
LA  - eng
PT  - Comment
PT  - Letter
PL  - United States
TA  - Hepatology
JT  - Hepatology (Baltimore, Md.)
JID - 8302946
RN  - 0 (Placebos)
SB  - IM
CON - Hepatology. 2011 Mar;53(3):774-80. PMID: 21294143
MH  - Acute Disease
MH  - *Bioethical Issues
MH  - Hepatitis B, Chronic/*drug therapy
MH  - Humans
MH  - Placebos/*therapeutic use
MH  - Severity of Illness Index
EDAT- 2011/05/04 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/05/04 06:00
PHST- 2011/05/04 06:00 [entrez]
PHST- 2011/05/04 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - 10.1002/hep.24392 [doi]
PST - ppublish
SO  - Hepatology. 2011 Aug;54(2):740; author reply 741-2. doi: 10.1002/hep.24392.


PMID- 21538126
OWN - NLM
STAT- MEDLINE
DCOM- 20120719
LR  - 20211020
IS  - 1590-3478 (Electronic)
IS  - 1590-1874 (Linking)
VI  - 33
IP  - 1
DP  - 2012 Feb
TI  - The Lombrosian prejudice in medicine. The case of epilepsy. Epileptic psychosis. 
      Epilepsy and aggressiveness.
PG  - 173-92
LID - 10.1007/s10072-011-0568-6 [doi]
AB  - In the nineteenth century, epilepsy became subject of experimental research.
      Lombroso established a relationship between epilepsy and criminality believing in
      the existence of epileptoid traits and atavism. He tried to demonstrate the
      common origin of epilepsy, criminality, and genius; factors deteriorating the CNS
      would act upon centers, which control behavior and ethics. This impairment would 
      cause a lack of control on the lower nervous centers, reducing restraints of
      instincts and criminal behavior. He described developmental frontal cortex
      lesions in epileptic patients (today Taylor's dysplasia) and these observations
      supported the erroneous conviction of a relationship between criminality and
      epilepsy. Neurological, behavioral, and criminological sciences analyzed
      Lombroso's doctrine, whereas it was controversial that epileptic patients should 
      be prone to violent actions and aggressive behavior. Today, there is an
      international panel of experts on epilepsy, which suggests five relevant criteria
      to determine if a crime committed with aggressiveness could result from epileptic
      seizures.
FAU - Granieri, Enrico
AU  - Granieri E
AD  - Department of Medical, Surgical Sciences of Communication and Behavior, Section
      of Neurology, University of Ferrara, Italy, Corso della Giovecca 203, 44100
      Ferrara, Italy. enrico.granieri@unife.it
FAU - Fazio, Patrik
AU  - Fazio P
LA  - eng
PT  - Biography
PT  - Historical Article
PT  - Journal Article
DEP - 20110503
PL  - Italy
TA  - Neurol Sci
JT  - Neurological sciences : official journal of the Italian Neurological Society and 
      of the Italian Society of Clinical Neurophysiology
JID - 100959175
SB  - IM
CIN - Neurol Sci. 2012 Feb;33(1):193-4. PMID: 21607755
MH  - Aggression/psychology
MH  - Criminals/psychology
MH  - Epilepsy/*history/psychology
MH  - History, 19th Century
MH  - Humans
MH  - Italy
MH  - Prejudice
PS  - Lombroso C
FPS - Lombroso, Cesare
EDAT- 2011/05/04 06:00
MHDA- 2012/07/20 06:00
CRDT- 2011/05/04 06:00
PHST- 2010/11/15 00:00 [received]
PHST- 2011/03/19 00:00 [accepted]
PHST- 2011/05/04 06:00 [entrez]
PHST- 2011/05/04 06:00 [pubmed]
PHST- 2012/07/20 06:00 [medline]
AID - 10.1007/s10072-011-0568-6 [doi]
PST - ppublish
SO  - Neurol Sci. 2012 Feb;33(1):173-92. doi: 10.1007/s10072-011-0568-6. Epub 2011 May 
      3.


PMID- 21538053
OWN - NLM
STAT- MEDLINE
DCOM- 20111212
LR  - 20211020
IS  - 1432-1262 (Electronic)
IS  - 0179-1958 (Linking)
VI  - 26
IP  - 9
DP  - 2011 Sep
TI  - Dynamic MRI defecography vs. entero-colpo-cysto-defecography in the evaluation of
      midline pelvic floor hernias in female pelvic floor disorders.
PG  - 1191-6
LID - 10.1007/s00384-011-1218-4 [doi]
AB  - PURPOSE: The aim of this study was to compare the diagnostic efficacy of dynamic 
      MR defecography (MR-D) with entero-colpo-cysto-defecography (ECCD) in the
      assessment of midline pelvic floor hernias (MPH) in female pelvic floor
      disorders. METHODS: From August 2004 to August 2010, 3,006 female patients who
      required ECCD for the evaluation of pelvic floor disorders were enrolled in this 
      study. All the 1,160 patients with ECCD findings of MPH were asked to undergo
      MR-D; 1,142 accepted to undergo MR-D and constituted the object of analysis. This
      study was approved by the Institutional Ethical Committee. All the patients gave 
      their written informed consent to take part in the study. RESULTS: Overall, the
      prevalence of MPH at ECCD was higher if compared with that at MR-D. Concerning
      the hernia content, there were significantly more enteroceles and sigmoidoceles
      on ECCD than on MR-D, whereas, in relation to the hernia development modalities, 
      the prevalence of elytroceles, edroceles, and Douglas' hernias at ECCD was
      significantly higher than that at MR-D. In spite of a 100% specificity, the
      sensibility of MR-D in the detection of an omentocele, sigmoidocele, and
      enterocele was, respectively, 95%, 82%, and 65%, showing an inferior diagnostic
      capacity if compared with that of ECCD. CONCLUSION: MR-D shows lower sensitivity 
      than ECCD in the detection of MPH development. The less-invasive MR-D may have a 
      role in a better evaluation of the entire pelvic anatomy and pelvic organ
      interaction especially in patients with multicompartmental defects, planned for
      surgery.
FAU - Cappabianca, Salvatore
AU  - Cappabianca S
AD  - Institute of Radiology, Second University of Naples, P.za Miraglia 2, 80138,
      Naples, Italy.
FAU - Reginelli, Alfonso
AU  - Reginelli A
FAU - Iacobellis, Francesca
AU  - Iacobellis F
FAU - Granata, Vincenza
AU  - Granata V
FAU - Urciuoli, Luigi
AU  - Urciuoli L
FAU - Alabiso, Maria Eleonora
AU  - Alabiso ME
FAU - Di Grezia, Graziella
AU  - Di Grezia G
FAU - Marano, Ines
AU  - Marano I
FAU - Gatta, Gianluca
AU  - Gatta G
FAU - Grassi, Roberto
AU  - Grassi R
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
DEP - 20110503
PL  - Germany
TA  - Int J Colorectal Dis
JT  - International journal of colorectal disease
JID - 8607899
SB  - IM
MH  - Defecography/*methods
MH  - Evaluation Studies as Topic
MH  - Female
MH  - Hernia/complications/*diagnostic imaging
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Pelvic Floor/*diagnostic imaging/*pathology
MH  - Pelvic Floor Disorders/complications/*diagnostic imaging
EDAT- 2011/05/04 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/05/04 06:00
PHST- 2011/04/14 00:00 [accepted]
PHST- 2011/05/04 06:00 [entrez]
PHST- 2011/05/04 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 10.1007/s00384-011-1218-4 [doi]
PST - ppublish
SO  - Int J Colorectal Dis. 2011 Sep;26(9):1191-6. doi: 10.1007/s00384-011-1218-4. Epub
      2011 May 3.


PMID- 21538039
OWN - NLM
STAT- MEDLINE
DCOM- 20111206
LR  - 20211020
IS  - 1546-9549 (Electronic)
IS  - 1546-9530 (Linking)
VI  - 8
IP  - 3
DP  - 2011 Sep
TI  - Palliative care and end-of-life issues in patients treated with left ventricular 
      assist devices as destination therapy.
PG  - 212-8
LID - 10.1007/s11897-011-0060-x [doi]
AB  - Left ventricular assist devices as destination therapy (DT) improve quality of
      life for many patients with advanced heart failure. However, DT can be associated
      with risks such as infection, bleeding, and stroke, and may impose psychosocial
      strain on patients and caregivers. Furthermore, patients treated with DT
      eventually will die with their device in place whether death is related to the
      device or not. In response to these concerns, palliative medicine consultation
      has been suggested with standard DT care to improve focus on quality of life,
      symptom management, and end-of-life planning. This article reviews key issues
      associated with caring for patients with DT, including psychosocial,
      quality-of-life, caregiving, and ethical issues, and discusses end-of-life
      management of patients with DT, including practical considerations, but moreover,
      review topics regarding communication, symptom management, and provision of
      appropriate comfort care.
FAU - Swetz, Keith M
AU  - Swetz KM
AD  - Division of General Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.
      swetz.keith@mayo.edu
FAU - Ottenberg, Abigale L
AU  - Ottenberg AL
FAU - Freeman, Monica R
AU  - Freeman MR
FAU - Mueller, Paul S
AU  - Mueller PS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Curr Heart Fail Rep
JT  - Current heart failure reports
JID - 101196487
SB  - IM
MH  - Advance Directives
MH  - Caregivers/psychology
MH  - Heart Failure/*psychology/*therapy
MH  - Heart-Assist Devices/ethics/*psychology
MH  - Humans
MH  - *Palliative Care
MH  - *Quality of Life
MH  - *Terminal Care
MH  - Ventricular Dysfunction, Left/*psychology/*therapy
EDAT- 2011/05/04 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/05/04 06:00
PHST- 2011/05/04 06:00 [entrez]
PHST- 2011/05/04 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/s11897-011-0060-x [doi]
PST - ppublish
SO  - Curr Heart Fail Rep. 2011 Sep;8(3):212-8. doi: 10.1007/s11897-011-0060-x.


PMID- 21537992
OWN - NLM
STAT- MEDLINE
DCOM- 20111114
LR  - 20211020
IS  - 1534-3170 (Electronic)
IS  - 1523-3782 (Linking)
VI  - 13
IP  - 4
DP  - 2011 Aug
TI  - Genetic counseling in the adult with congenital heart disease: what is the role?
PG  - 347-55
LID - 10.1007/s11886-011-0188-z [doi]
AB  - New discoveries using high-resolution methods for detecting genetic aberrations
      indicate that the genetic contribution to congenital heart disease has been
      significantly underestimated in the past. DNA diagnostics have become more
      accessible and genetic test results are increasingly being used to guide clinical
      management. Adult congenital heart disease specialists seeking to counsel adults 
      with congenital heart disease about the genetic aspects of their condition face
      the challenge of keeping abreast of new genetic techniques and discoveries. The
      emphasis of this review is on the genetic basis of structural cardiovascular
      defects. A framework for identifying adult congenital heart disease patients most
      likely to benefit from genetic testing is suggested, along with a summary of
      current techniques for genetic testing. The clinical and ethical challenges
      associated with genetic counseling are highlighted. Finally, emerging
      technologies and future directions in genetics and adult congenital heart disease
      are discussed.
FAU - Burchill, Luke
AU  - Burchill L
AD  - Department of Medicine, Division of Cardiology, Toronto General Hospital,
      Toronto, ON, Canada.
FAU - Greenway, Steven
AU  - Greenway S
FAU - Silversides, Candice K
AU  - Silversides CK
FAU - Mital, Seema
AU  - Mital S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Curr Cardiol Rep
JT  - Current cardiology reports
JID - 100888969
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Genetic Counseling/*methods
MH  - Genetic Testing/*methods
MH  - Genetic Variation
MH  - Heart Defects, Congenital/*epidemiology
MH  - Humans
MH  - *Professional Role
MH  - Recurrence
MH  - United States/epidemiology
EDAT- 2011/05/04 06:00
MHDA- 2011/11/15 06:00
CRDT- 2011/05/04 06:00
PHST- 2011/05/04 06:00 [entrez]
PHST- 2011/05/04 06:00 [pubmed]
PHST- 2011/11/15 06:00 [medline]
AID - 10.1007/s11886-011-0188-z [doi]
PST - ppublish
SO  - Curr Cardiol Rep. 2011 Aug;13(4):347-55. doi: 10.1007/s11886-011-0188-z.


PMID- 21537685
OWN - NLM
STAT- MEDLINE
DCOM- 20111025
LR  - 20220330
IS  - 1678-8060 (Electronic)
IS  - 0074-0276 (Linking)
VI  - 106
IP  - 2
DP  - 2011 Mar
TI  - Parvovirus B19 antibodies and correlates of infection in pregnant women attending
      an antenatal clinic in central Nigeria.
PG  - 227-31
LID - S0074-02762011000200018 [pii]
AB  - Human parvovirus B19 infection is associated with spontaneous abortion, hydrops
      foetalis, intrauterine foetal death, erythema infectiosum (5th disease), aplastic
      crisis and acute symmetric polyarthropathy. However, data concerning Nigerian
      patients with B19 infection have not been published yet. The purpose of this
      study was to establish the prevalence of B19 IgG and IgM antibodies, including
      correlates of infection, among pregnant women attending an antenatal clinic in
      Nigeria. Subsequent to clearance from an ethical committee, blood samples were
      collected between August-November 2008 from 273 pregnant women between the ages
      of 15-40 years who have given their informed consent and completed
      self-administered questionnaires. Recombinant IgG and IgM enzyme linked
      immunosorbent assay kits (Demeditec Diagnostics, Germany) were used for the
      assays. Out of the 273 participants, 111 (40.7%) had either IgG or IgM
      antibodies. Out of these, 75 (27.5%) had IgG antibodies whereas 36 (13.2%) had
      IgM antibodies, and those aged 36-40 years had the highest prevalence of IgG
      antibodies. Significant determinants of infection (p < 0.05) included the receipt
      of a blood transfusion, occupation and the presence of a large number of children
      in the household. Our findings have important implications for transfusion and
      foeto-maternal health policy in Nigeria. Routine screening for B19 IgM antibodies
      and accompanying clinical management of positive cases should be made mandatory
      for all Nigerian blood donors and women of childbearing age.
FAU - Emiasegen, Samuel E
AU  - Emiasegen SE
AD  - Department of Medical Microbiology, University of Jos, Plateau State, Nigeria.
FAU - Nimzing, Lohya
AU  - Nimzing L
FAU - Adoga, Moses P
AU  - Adoga MP
FAU - Ohagenyi, Adamu Y
AU  - Ohagenyi AY
FAU - Lekan, Rufai
AU  - Lekan R
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - Mem Inst Oswaldo Cruz
JT  - Memorias do Instituto Oswaldo Cruz
JID - 7502619
RN  - 0 (Antibodies, Viral)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antibodies, Viral/*blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Immunoglobulin G/*blood
MH  - Immunoglobulin M/*blood
MH  - Nigeria/epidemiology
MH  - Parvoviridae Infections/diagnosis/*epidemiology/immunology
MH  - Parvovirus B19, Human/*immunology
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/diagnosis/*epidemiology/immunology/virology
MH  - Prevalence
MH  - Risk Factors
MH  - Young Adult
EDAT- 2011/05/04 06:00
MHDA- 2011/10/26 06:00
CRDT- 2011/05/04 06:00
PHST- 2010/09/30 00:00 [received]
PHST- 2011/01/14 00:00 [accepted]
PHST- 2011/05/04 06:00 [entrez]
PHST- 2011/05/04 06:00 [pubmed]
PHST- 2011/10/26 06:00 [medline]
AID - S0074-02762011000200018 [pii]
AID - 10.1590/s0074-02762011000200018 [doi]
PST - ppublish
SO  - Mem Inst Oswaldo Cruz. 2011 Mar;106(2):227-31. doi:
      10.1590/s0074-02762011000200018.


PMID- 21537630
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20191027
IS  - 1808-8686 (Electronic)
IS  - 1808-8686 (Linking)
VI  - 77
IP  - 2
DP  - 2011 Mar-Apr
TI  - Current outlook of ethics in research with human subjects.
PG  - 263-6
LID - S1808-86942011000200018 [pii]
AB  - UNLABELLED: In the last decades, medical care has been increasingly permeated by 
      the concept of evidence-based-medicine, in which clinical research plays a
      crucial role in establishing diagnostic and treatment. Following the improvements
      in clinical research, we have a growing concern and understanding that some
      ethical issues must be respected when the subjects are human beings. Research
      with human subjects relies on the principles of autonomy, beneficence, no
      maleficence and justice. Ordinance 196/96 from the National Health Board adds to 
      the Brazilian legislation such renowned bioethical principles. AIM: Discuss the
      main ethical aspects involved in research with human subjects. MATERIALS AND
      METHODS: Critical analysis of Ordinance 196/96 and related literature.
      CONCLUSION: Ordinance 196/96 rules research with human subjects; nevertheless, it
      requires more in-depth discussions regarding the informed consent, use of
      placebo, research with vulnerable populations and research in developing
      countries.
FAU - Takahashi, Marystella Tomoe
AU  - Takahashi MT
AD  - University Hospital, Medical School, University of Sao Paulo, Brazil.
FAU - Ramos, Henrique Faria
AU  - Ramos HF
FAU - Pinheiro-Neto, Carlos Diogenes
AU  - Pinheiro-Neto CD
FAU - Miziara, Ivan Dieb
AU  - Miziara ID
FAU - Oliveira, Reynaldo Ayer de
AU  - Oliveira RA
LA  - eng
LA  - por
PT  - Journal Article
PT  - Review
PL  - Brazil
TA  - Braz J Otorhinolaryngol
JT  - Brazilian journal of otorhinolaryngology
JID - 101207337
SB  - IM
MH  - Brazil
MH  - *Ethics, Research
MH  - Human Experimentation/*ethics/legislation & jurisprudence
MH  - Humans
EDAT- 2011/05/04 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/05/04 06:00
PHST- 2009/12/16 00:00 [received]
PHST- 2010/01/03 00:00 [accepted]
PHST- 2011/05/04 06:00 [entrez]
PHST- 2011/05/04 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - S1808-8694(15)30818-1 [pii]
AID - 10.1590/s1808-86942011000200018 [doi]
PST - ppublish
SO  - Braz J Otorhinolaryngol. 2011 Mar-Apr;77(2):263-6. doi:
      10.1590/s1808-86942011000200018.


PMID- 21537133
OWN - NLM
STAT- MEDLINE
DCOM- 20110907
LR  - 20110503
IS  - 1550-512X (Electronic)
IS  - 1525-5794 (Linking)
VI  - 30
IP  - 2
DP  - 2011 Apr-Jun
TI  - The ethical leadership challenge: creating a culture of patient- and
      family-centered care in the hospital setting.
PG  - 125-32
LID - 10.1097/HCM.0b013e318216efb9 [doi]
AB  - The growing number of medical errors and resulting preventable deaths in
      hospitals presents an ethical dilemma that must be addressed by health care
      leaders and managers. These medical errors and deaths raise questions about
      safety and quality issues resulting in rising public mistrust and patient
      dissatisfaction. Many of these medical errors and deaths could have been avoided 
      by including the patient and family in the care. The ethical challenge for
      leadership is creating a culture of patient- and family-centered care as a means 
      to improve quality, safety, patient satisfaction, and public trust. This article 
      addresses ways to improve safety, quality, patient satisfaction, and cost and
      thereby reduce medical errors and deaths by implementing a patient- and
      family-centered care culture. The first critical step for improvement is for
      hospital leaders and managers to answer the ethical call to create a culture
      centered on patient- and family-centered care in the hospital setting.
FAU - Piper, Llewellyn E
AU  - Piper LE
AD  - Onslow Memorial Hospital, Jacksonville, North Carolina, USA.
      Sharon.turner@onslow.org
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Health Care Manag (Frederick)
JT  - The health care manager
JID - 100896672
MH  - Family Nursing/*ethics/organization & administration
MH  - *Hospitals
MH  - Humans
MH  - *Leadership
MH  - Medical Errors/prevention & control
MH  - *Organizational Culture
MH  - Patient Satisfaction
MH  - Patient-Centered Care/*ethics/organization & administration
MH  - Quality of Health Care
MH  - Safety Management
EDAT- 2011/05/04 06:00
MHDA- 2011/09/08 06:00
CRDT- 2011/05/04 06:00
PHST- 2011/05/04 06:00 [entrez]
PHST- 2011/05/04 06:00 [pubmed]
PHST- 2011/09/08 06:00 [medline]
AID - 10.1097/HCM.0b013e318216efb9 [doi]
AID - 00126450-201104000-00004 [pii]
PST - ppublish
SO  - Health Care Manag (Frederick). 2011 Apr-Jun;30(2):125-32. doi:
      10.1097/HCM.0b013e318216efb9.


PMID- 21536837
OWN - NLM
STAT- MEDLINE
DCOM- 20120315
LR  - 20211020
IS  - 1534-7796 (Electronic)
IS  - 0033-3174 (Linking)
VI  - 73
IP  - 4
DP  - 2011 May
TI  - Usual and unusual care: existing practice control groups in randomized controlled
      trials of behavioral interventions.
PG  - 323-35
LID - 10.1097/PSY.0b013e318218e1fb [doi]
AB  - OBJECTIVE: To evaluate the use of existing practice control groups in randomized 
      controlled trials of behavioral interventions and the role of extrinsic health
      care services in the design and conduct of behavioral trials. METHOD: Selective
      qualitative review. RESULTS: Extrinsic health care services, also known as
      nonstudy care, have important but under-recognized effects on the design and
      conduct of behavioral trials. Usual care, treatment-as-usual, standard of care,
      and other existing practice control groups pose a variety of methodological and
      ethical challenges, but they play a vital role in behavioral intervention
      research. CONCLUSIONS: This review highlights the need for a scientific consensus
      statement on control groups in behavioral trials.
FAU - Freedland, Kenneth E
AU  - Freedland KE
AD  - Department of Psychiatry, Washington University School of Medicine, 4320 Forest
      Park Ave, Suite 301, St Louis, Missouri 63108, USA. freedlak@bmc.wustl.edu
FAU - Mohr, David C
AU  - Mohr DC
FAU - Davidson, Karina W
AU  - Davidson KW
FAU - Schwartz, Joseph E
AU  - Schwartz JE
LA  - eng
GR  - R01 HL091918/HL/NHLBI NIH HHS/United States
GR  - R01 HL091918-03/HL/NHLBI NIH HHS/United States
GR  - RL1 HD058295/HD/NICHD NIH HHS/United States
GR  - UL1 RR025741/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20110502
PL  - United States
TA  - Psychosom Med
JT  - Psychosomatic medicine
JID - 0376505
SB  - IM
MH  - Behavior Therapy/standards
MH  - Behavioral Research/ethics/*methods
MH  - Confounding Factors, Epidemiologic
MH  - *Control Groups
MH  - *Evidence-Based Medicine
MH  - Humans
MH  - Randomized Controlled Trials as Topic/ethics/*methods
MH  - Research Design
MH  - Standard of Care
PMC - PMC3091006
MID - NIHMS288854
EDAT- 2011/05/04 06:00
MHDA- 2012/03/16 06:00
CRDT- 2011/05/04 06:00
PHST- 2011/05/04 06:00 [entrez]
PHST- 2011/05/04 06:00 [pubmed]
PHST- 2012/03/16 06:00 [medline]
AID - PSY.0b013e318218e1fb [pii]
AID - 10.1097/PSY.0b013e318218e1fb [doi]
PST - ppublish
SO  - Psychosom Med. 2011 May;73(4):323-35. doi: 10.1097/PSY.0b013e318218e1fb. Epub
      2011 May 2.


PMID- 21536713
OWN - NLM
STAT- MEDLINE
DCOM- 20111123
LR  - 20220310
IS  - 1465-3648 (Electronic)
IS  - 0268-1153 (Linking)
VI  - 26
IP  - 4
DP  - 2011 Aug
TI  - Hong Kong Chinese community leaders' perspectives on family health, happiness and
      harmony: a qualitative study.
PG  - 664-74
LID - 10.1093/her/cyr026 [doi]
AB  - This paper examines the views of Hong Kong community leaders on the underlying
      issues that affect family health, happiness and harmony (3Hs) in Hong Kong. Using
      a community reconnaissance method, a series of individual in-depth interviews
      with 26 leaders that represent neighbourhoods of diverse socio-economic status
      (SES) from June to August 2008 were conducted. Participants considered that
      changing family structure, economic situation and strong work ethic are the most 
      salient factors that affect family 3Hs. The deprived comprehensive social
      security assistance recipients, single-parent families and migrant women were
      considered to be the most vulnerable groups to breakdown in family 3Hs and
      particularly, they lack family resources. Families from different SES have to
      overcome different challenges in order to achieve and sustain family 3Hs. Leaders
      from low SES neighbourhood were concerned more about providing tangible help such
      as child care facilities to improve family resources, whereas leaders from high
      SES neighbourhood focused more on preventive interventions such as education on
      relationship skills to achieve better family well-being. The findings offer
      insights in designing effective social marketing education campaigns and
      family-friendly workplace policy to promote social harmony through the
      maintenance of 3Hs families.
FAU - Chan, Sophia S C
AU  - Chan SS
AD  - School of Nursing, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 
      Hong Kong, China. nssophia@hku.hk
FAU - Viswanath, K
AU  - Viswanath K
FAU - Au, Doreen W H
AU  - Au DW
FAU - Ma, C M S
AU  - Ma CM
FAU - Lam, W W T
AU  - Lam WW
FAU - Fielding, R
AU  - Fielding R
FAU - Leung, G M
AU  - Leung GM
FAU - Lam, Tai-Hing
AU  - Lam TH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110502
PL  - England
TA  - Health Educ Res
JT  - Health education research
JID - 8608459
MH  - Adult
MH  - *Family
MH  - Female
MH  - *Happiness
MH  - *Health Status
MH  - Hong Kong
MH  - Humans
MH  - Leadership
MH  - Male
MH  - Middle Aged
MH  - *Perception
MH  - Qualitative Research
MH  - Residence Characteristics
MH  - Socioeconomic Factors
EDAT- 2011/05/04 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/05/04 06:00
PHST- 2011/05/04 06:00 [entrez]
PHST- 2011/05/04 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - cyr026 [pii]
AID - 10.1093/her/cyr026 [doi]
PST - ppublish
SO  - Health Educ Res. 2011 Aug;26(4):664-74. doi: 10.1093/her/cyr026. Epub 2011 May 2.


PMID- 21536502
OWN - NLM
STAT- MEDLINE
DCOM- 20111013
LR  - 20110613
IS  - 1873-5010 (Electronic)
IS  - 1569-1993 (Linking)
VI  - 10
IP  - 4
DP  - 2011 Jul
TI  - Communication of information about reproductive and sexual health in cystic
      fibrosis. Patients, parents and caregivers' experience.
PG  - 221-7
LID - 10.1016/j.jcf.2011.04.001 [doi]
AB  - BACKGROUND: This review evaluated research concerning communication and
      information about reproductive and sexual health (RSH) in cystic fibrosis (CF).
      METHODS: Papers in the English language reporting RSH issues in CF, published
      between January 2000 and December 2010, were included. The review focused on (a) 
      the content of information given to parents and patients, (b) the timing of
      information, (c) the sources of information, (d) attitudes and emotional
      reactions, (e) chronic illness and sexual behavior, (f) methodological and
      cultural considerations and (g) ethical considerations. RESULTS: Eleven papers
      were identified originating from Australia, the United Kingdom and Poland.
      Patients and parents expressed the need for up-to-date, CF-related verbal and
      written information, provided by the CF team and infertility specialists.
      Patients were often embarrassed to initiate a discussion. Health care providers
      expressed the need for training to counsel patients in RSH. CONCLUSION: A
      pro-active discussion of RSH issues is proposed as a standard part of the
      care-pathway. A list of recommendations is given to initiate this process.
CI  - Copyright (c) 2011 European Cystic Fibrosis Society. Published by Elsevier B.V.
      All rights reserved.
FAU - Havermans, Trudy
AU  - Havermans T
AD  - Cystic Fibrosis Centre, University Hospital Leuven, Belgium.
      trudy.havermans@uzleuven.be
FAU - Abbott, Janice
AU  - Abbott J
FAU - Colpaert, Kristine
AU  - Colpaert K
FAU - De Boeck, Kris
AU  - De Boeck K
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110504
PL  - Netherlands
TA  - J Cyst Fibros
JT  - Journal of cystic fibrosis : official journal of the European Cystic Fibrosis
      Society
JID - 101128966
SB  - IM
MH  - *Communication
MH  - Cystic Fibrosis/*psychology
MH  - Humans
MH  - Parents/psychology
MH  - *Patient Education as Topic
MH  - *Physician-Patient Relations
MH  - *Reproductive Medicine
MH  - Sexuality/*psychology
EDAT- 2011/05/04 06:00
MHDA- 2011/10/14 06:00
CRDT- 2011/05/04 06:00
PHST- 2011/01/29 00:00 [received]
PHST- 2011/04/01 00:00 [revised]
PHST- 2011/04/04 00:00 [accepted]
PHST- 2011/05/04 06:00 [entrez]
PHST- 2011/05/04 06:00 [pubmed]
PHST- 2011/10/14 06:00 [medline]
AID - S1569-1993(11)00051-8 [pii]
AID - 10.1016/j.jcf.2011.04.001 [doi]
PST - ppublish
SO  - J Cyst Fibros. 2011 Jul;10(4):221-7. doi: 10.1016/j.jcf.2011.04.001. Epub 2011
      May 4.


PMID- 21536349
OWN - NLM
STAT- MEDLINE
DCOM- 20120110
LR  - 20211020
IS  - 1578-1275 (Electronic)
IS  - 0212-6567 (Linking)
VI  - 43
IP  - 9
DP  - 2011 Sep
TI  - [Ethics and esthetics in international cooperation].
PG  - 497-502
LID - 10.1016/j.aprim.2010.09.023 [doi]
AB  - Although more optimistic, the new report by the World Health Organization (WHO)
      continues to cast horrifying statistics on inequalities, not only in life
      expectancy but in many areas. Many Non-Governmental Organisations (NGOs) related 
      to medicine seek to address this imbalance. To cooperate does not in any way
      appeal to the call of sentimentality. Cooperation moves money and is accountable.
      It requires a strong background in both professional and human values. It
      requires research on vaccines and diseases foreign to our society. To cooperate
      means "operate with" local counterparts, according to their needs and global
      health project. And finally, cooperation implies the demand for change in certain
      aspects of the global economic order. We reflect on these questions and describe 
      the different ethical frameworks for the population and NGOs.
CI  - Copyright (c) 2010 Elsevier Espana, S.L. All rights reserved.
FAU - de Aranzabal Agudo, Maite
AU  - de Aranzabal Agudo M
AD  - Equipo de Atencion Primaria Centro de Salud Lakua-Arriaga, Vitoria-Gasteiz,
      Espana. mdearanzabal@gmail.com
FAU - Hermana Tezanos, Maria Teresa
AU  - Hermana Tezanos MT
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Etica y estetica en la Cooperacion Internacional.
DEP - 20110504
PL  - Spain
TA  - Aten Primaria
JT  - Atencion primaria
JID - 9111075
SB  - IM
MH  - *Codes of Ethics
MH  - Esthetics
MH  - *International Cooperation
MH  - Organizations/*ethics
PMC - PMC7025058
EDAT- 2011/05/04 06:00
MHDA- 2012/01/11 06:00
CRDT- 2011/05/04 06:00
PHST- 2010/05/18 00:00 [received]
PHST- 2010/09/20 00:00 [revised]
PHST- 2010/09/22 00:00 [accepted]
PHST- 2011/05/04 06:00 [entrez]
PHST- 2011/05/04 06:00 [pubmed]
PHST- 2012/01/11 06:00 [medline]
AID - S0212-6567(11)00069-2 [pii]
AID - 10.1016/j.aprim.2010.09.023 [doi]
PST - ppublish
SO  - Aten Primaria. 2011 Sep;43(9):497-502. doi: 10.1016/j.aprim.2010.09.023. Epub
      2011 May 4.


PMID- 21536344
OWN - NLM
STAT- MEDLINE
DCOM- 20110825
LR  - 20151119
IS  - 1097-6787 (Electronic)
IS  - 0190-9622 (Linking)
VI  - 65
IP  - 1
DP  - 2011 Jul
TI  - Should one offer an unsolicited dermatologic opinion? Ethics for the locker-room 
      dermatologist.
PG  - 134-6
LID - 10.1016/j.jaad.2010.12.027 [doi]
FAU - Bercovitch, Lionel
AU  - Bercovitch L
AD  - Department of Dermatology, Warren Alpert Medical School, Brown University and
      Rhode Island Hospital, Providence, Rhode Island 02903, USA.
      Lionel_Bercovitch@brown.edu
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20110504
PL  - United States
TA  - J Am Acad Dermatol
JT  - Journal of the American Academy of Dermatology
JID - 7907132
SB  - IM
MH  - Attitude of Health Personnel
MH  - Decision Making
MH  - Dermatology/*ethics
MH  - Female
MH  - Humans
MH  - Practice Patterns, Physicians'/*ethics
EDAT- 2011/05/04 06:00
MHDA- 2011/08/27 06:00
CRDT- 2011/05/04 06:00
PHST- 2010/11/03 00:00 [received]
PHST- 2010/12/09 00:00 [revised]
PHST- 2010/12/10 00:00 [accepted]
PHST- 2011/05/04 06:00 [entrez]
PHST- 2011/05/04 06:00 [pubmed]
PHST- 2011/08/27 06:00 [medline]
AID - S0190-9622(10)02267-X [pii]
AID - 10.1016/j.jaad.2010.12.027 [doi]
PST - ppublish
SO  - J Am Acad Dermatol. 2011 Jul;65(1):134-6. doi: 10.1016/j.jaad.2010.12.027. Epub
      2011 May 4.


PMID- 21535895
OWN - NLM
STAT- MEDLINE
DCOM- 20110916
LR  - 20220317
IS  - 1471-2407 (Electronic)
IS  - 1471-2407 (Linking)
VI  - 11
DP  - 2011 May 2
TI  - Admission of advanced lung cancer patients to intensive care unit: a
      retrospective study of 76 patients.
PG  - 159
LID - 10.1186/1471-2407-11-159 [doi]
AB  - BACKGROUND: Criteria for admitting patients with incurable diseases to the
      medical intensive care unit (MICU) remain unclear and have ethical implications. 
      METHODS: We retrospectively evaluated MICU outcomes and identified risk factors
      for MICU mortality in consecutive patients with advanced lung cancer admitted to 
      two university-hospital MICUs in France between 1996 and 2006. RESULTS: Of 76
      included patients, 49 had non-small cell lung cancer (stage IIIB n = 20; stage IV
      n = 29). In 60 patients, MICU admission was directly related to the lung cancer
      (complication of cancer management, n = 30; cancer progression, n = 14; and
      lung-cancer-induced diseases, n = 17). Mechanical ventilation was required during
      the MICU stay in 57 patients. Thirty-six (47.4%) patients died in the MICU. Three
      factors were independently associated with MICU mortality: use of vasoactive
      agents (odds ratio [OR] 6.81 95% confidence interval [95%CI] [1.77-26.26], p =
      0.005), mechanical ventilation (OR 6.61 95%CI [1.44-30.5], p = 0.015) and
      thrombocytopenia (OR 5.13; 95%CI [1.17-22.5], p = 0.030). In contrast, mortality 
      was lower in patients admitted for a complication of cancer management (OR 0.206;
      95%CI [0.058-0.738], p = 0.015). Of the 27 patients who returned home, four
      received specific lung cancer treatment after the MICU stay. CONCLUSIONS:
      Patients with acute complications of treatment for advanced lung cancer may
      benefit from MCIU admission. Further studies are necessary to assess outcomes
      such as quality of life after MICU discharge.
FAU - Andrejak, Claire
AU  - Andrejak C
AD  - Service de Pneumologie et Reanimation, Centre Hospitalier Universitaire, Amiens, 
      France. clandrejak@gmail.com
FAU - Terzi, Nicolas
AU  - Terzi N
FAU - Thielen, Stephanie
AU  - Thielen S
FAU - Bergot, Emmanuel
AU  - Bergot E
FAU - Zalcman, Gerard
AU  - Zalcman G
FAU - Charbonneau, Pierre
AU  - Charbonneau P
FAU - Jounieaux, Vincent
AU  - Jounieaux V
LA  - eng
PT  - Journal Article
DEP - 20110502
PL  - England
TA  - BMC Cancer
JT  - BMC cancer
JID - 100967800
SB  - IM
MH  - Aged
MH  - Female
MH  - Humans
MH  - Intensive Care Units/*statistics & numerical data
MH  - Lung Neoplasms/mortality/*pathology/*therapy
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Patient Admission/*statistics & numerical data
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Survival Analysis
MH  - Treatment Outcome
PMC - PMC3112156
EDAT- 2011/05/04 06:00
MHDA- 2011/09/17 06:00
CRDT- 2011/05/04 06:00
PHST- 2010/09/20 00:00 [received]
PHST- 2011/05/02 00:00 [accepted]
PHST- 2011/05/04 06:00 [entrez]
PHST- 2011/05/04 06:00 [pubmed]
PHST- 2011/09/17 06:00 [medline]
AID - 1471-2407-11-159 [pii]
AID - 10.1186/1471-2407-11-159 [doi]
PST - epublish
SO  - BMC Cancer. 2011 May 2;11:159. doi: 10.1186/1471-2407-11-159.


PMID- 21535127
OWN - NLM
STAT- MEDLINE
DCOM- 20120329
LR  - 20140730
IS  - 1651-2227 (Electronic)
IS  - 0803-5253 (Linking)
VI  - 100
IP  - 10
DP  - 2011 Oct
TI  - Can we prevent sudden cardiac death in young athletes: the debate about
      preparticipation sports screening.
PG  - 1297-301
LID - 10.1111/j.1651-2227.2011.02337.x [doi]
AB  - UNLABELLED: All high school athletes in the United States require a
      preparticipation screening examination. The American Heart Association recommends
      a focused history and physical examination. The European Society of Cardiology
      recommends that all examinations include an electrocardiogram (ECG). We review
      the risks and costs of screening, discuss legal ramifications and analyse the
      ethical implications of these considerations. There are too many unknown about
      ECG screening to require it as routine testing for all high school athletes.
      CONCLUSION: Doctors must inform young athletes and their parents about the option
      of ECG screening and about the debate over its efficacy. Patients and parents may
      then choose to have an ECG or not. Mandatory universal screening is not warranted
      at this time.
CI  - (c) 2011 The Author(s)/Acta Paediatrica (c) 2011 Foundation Acta Paediatrica.
FAU - Patel, Angira
AU  - Patel A
AD  - Division of Cardiology, Children's Memorial Hospital, Chicago, IL 64108, USA.
FAU - Lantos, John D
AU  - Lantos JD
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110601
PL  - Norway
TA  - Acta Paediatr
JT  - Acta paediatrica (Oslo, Norway : 1992)
JID - 9205968
SB  - IM
MH  - Adolescent
MH  - *Athletes
MH  - Cost-Benefit Analysis
MH  - Death, Sudden, Cardiac/*prevention & control
MH  - Dissent and Disputes
MH  - Electrocardiography
MH  - Humans
MH  - Liability, Legal
MH  - *Mass Screening/economics/legislation & jurisprudence
MH  - Practice Guidelines as Topic
MH  - Risk
MH  - United States
EDAT- 2011/05/04 06:00
MHDA- 2012/03/30 06:00
CRDT- 2011/05/04 06:00
PHST- 2011/05/04 06:00 [entrez]
PHST- 2011/05/04 06:00 [pubmed]
PHST- 2012/03/30 06:00 [medline]
AID - 10.1111/j.1651-2227.2011.02337.x [doi]
PST - ppublish
SO  - Acta Paediatr. 2011 Oct;100(10):1297-301. doi: 10.1111/j.1651-2227.2011.02337.x. 
      Epub 2011 Jun 1.


PMID- 21535063
OWN - NLM
STAT- MEDLINE
DCOM- 20130220
LR  - 20120913
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 26
IP  - 8
DP  - 2012 Oct
TI  - Ethical concerns regarding commercialization of deep brain stimulation for
      obsessive compulsive disorder.
PG  - 440-6
LID - 10.1111/j.1467-8519.2011.01886.x [doi]
AB  - The United States Food and Drug Administration's recent approval of the
      commercial use of Deep Brain Stimulation (DBS) as a treatment for Obsessive
      Compulsive Disorder (OCD) will be discussed within the context of the existing
      USA regulatory framework. The purpose will be to illustrate the current lack of
      regulation and oversight of the DBS market, which has resulted in the violation
      of basic ethical norms. The discussion will focus on: 1) the lack of available
      evidence on procedural safety and efficacy, 2) the numerous conflicts of interest
      held by research investigators, and 3) the ambiguity of both aforementioned
      categories due to an inherent lack of transparency in the research. It is argued 
      that in order to address these issues, ethical analyses of DBS for psychiatric
      disorders must include the role of the industry forces that have become the
      primary impetus for this research. As such, DBS for OCD serves as an important
      case example in studies of neurotechnology and innovative surgery.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Erickson-Davis, Cordelia
AU  - Erickson-Davis C
AD  - Mailman School of Public Health, Columbia University, Department of Sociomedical 
      Sciences, 701 W. 168 St, New York, NY 10032, USA. cordeliaedavis@gmail.com
LA  - eng
PT  - Journal Article
DEP - 20110429
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Conflict of Interest/legislation & jurisprudence
MH  - Deep Brain Stimulation/*ethics
MH  - Device Approval/*legislation & jurisprudence
MH  - Ethics, Research
MH  - Humans
MH  - Obsessive-Compulsive Disorder/*therapy
MH  - Off-Label Use/*ethics/legislation & jurisprudence
MH  - Patient Safety/legislation & jurisprudence
MH  - *Technology Transfer
MH  - United States
EDAT- 2011/05/04 06:00
MHDA- 2013/02/21 06:00
CRDT- 2011/05/04 06:00
PHST- 2011/05/04 06:00 [entrez]
PHST- 2011/05/04 06:00 [pubmed]
PHST- 2013/02/21 06:00 [medline]
AID - 10.1111/j.1467-8519.2011.01886.x [doi]
PST - ppublish
SO  - Bioethics. 2012 Oct;26(8):440-6. doi: 10.1111/j.1467-8519.2011.01886.x. Epub 2011
      Apr 29.


PMID- 21534638
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20211020
IS  - 1179-1969 (Electronic)
IS  - 1170-229X (Linking)
VI  - 28
IP  - 6
DP  - 2011 Jun 1
TI  - Medical foods for Alzheimer's disease.
PG  - 421-8
LID - 10.2165/11587380-000000000-00000 [doi]
AB  - Alzheimer's disease (AD) is a neurodegenerative condition associated with
      cognitive loss, behavioural changes, functional ability decline and caregiver
      burden. Given the worldwide public health impact of AD, novel interventions to
      reduce suffering experienced by AD patients need to be developed. Foods may offer
      a mechanism for intervention complementary to drugs, devices, biologicals and
      vaccines. Apart from foods with health claims (including dietary supplements),
      medical foods are also being explored as an intervention option. The purpose of
      this article is to describe how medical foods may complement other interventions 
      for AD patients by: (i) defining what a medical food is; (ii) discussing whether 
      AD is a condition amenable to medical food intervention; (iii) reviewing current 
      clinical trial data on medical foods used in participants with AD; and (iv)
      highlighting steps needed to establish a more comprehensive framework for
      developing medical foods for AD. While medical foods may be defined differently
      in other countries, the US Orphan Drug Act of 1998 defined a medical food as a
      food formulated for enteral intake, taken under physician supervision, and
      intended to meet the distinctive nutritional requirements identified for a
      disease or condition. For AD to be amenable to medical food intervention, it
      must: (i) result in limited or impaired capacity to ingest, digest, absorb or
      metabolize ordinary foodstuff or certain nutrients; or (ii) have unique,
      medically determined nutrient requirements; and (iii) require dietary management 
      that cannot be achieved by modification of the normal diet alone. While these
      criteria are most likely met in advanced AD, identifying unique nutritional
      requirements in early AD that cannot be met by normal diet modification requires 
      a better understanding of AD pathophysiology. A PubMed search using the terms
      'medical food' and 'Alzheimer', limited to clinical trials published in English
      with human participants with AD aged >65 years and supplemented by other articles
      known to meet the inclusion criteria, revealed that only two medical foods,
      AC-1202 and Souvenaid(R) with Fortasyn Connect, have clinical trial results
      available for discussion. As medical food development for AD is a relatively new 
      endeavour, a window of opportunity exists for all stakeholders to develop a
      comprehensive framework for assuring that medical food interventions for AD
      achieve the highest possible scientific and ethical standards to warrant
      commercialization.
FAU - Shah, Raj C
AU  - Shah RC
AD  - The Rush Alzheimer's Disease Center and Department of Family Medicine, Rush
      University Medical Center, Chicago, Illinois, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - New Zealand
TA  - Drugs Aging
JT  - Drugs & aging
JID - 9102074
SB  - IM
MH  - Alzheimer Disease/*diet therapy
MH  - Animals
MH  - Clinical Trials as Topic
MH  - *Food
MH  - Humans
EDAT- 2011/05/04 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/05/04 06:00
PHST- 2011/05/04 06:00 [entrez]
PHST- 2011/05/04 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - 10.2165/11587380-000000000-00000 [doi]
PST - ppublish
SO  - Drugs Aging. 2011 Jun 1;28(6):421-8. doi: 10.2165/11587380-000000000-00000.


PMID- 21534387
OWN - NLM
STAT- MEDLINE
DCOM- 20110623
LR  - 20190923
IS  - 1547-1896 (Print)
IS  - 0893-7400 (Linking)
VI  - 24
IP  - 4
DP  - 2011 Apr
TI  - HIV exceptionalism and ethical concerns surrounding HIV testing.
PG  - 66, 68
FAU - O'Hara, Kevin Michael
AU  - O'Hara KM
AD  - Department of Sociomedical Sciences, Columbia University, New York, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - JAAPA
JT  - JAAPA : official journal of the American Academy of Physician Assistants
JID - 9513102
RN  - 0 (HIV Antibodies)
MH  - AIDS Serodiagnosis/*ethics
MH  - Counseling
MH  - HIV Antibodies/blood
MH  - Humans
MH  - Informed Consent/*ethics
EDAT- 2011/05/04 06:00
MHDA- 2011/06/24 06:00
CRDT- 2011/05/04 06:00
PHST- 2011/05/04 06:00 [entrez]
PHST- 2011/05/04 06:00 [pubmed]
PHST- 2011/06/24 06:00 [medline]
AID - 10.1097/01720610-201104000-00013 [doi]
PST - ppublish
SO  - JAAPA. 2011 Apr;24(4):66, 68. doi: 10.1097/01720610-201104000-00013.


PMID- 21534151
OWN - NLM
STAT- MEDLINE
DCOM- 20110712
LR  - 20211203
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 11
IP  - 5
DP  - 2011 May
TI  - An ethically justified framework for clinical investigation to benefit pregnant
      and fetal patients.
PG  - 39-49
LID - 10.1080/15265161.2011.562595 [doi]
AB  - Research to improve the health of pregnant and fetal patients presents ethical
      challenges to clinical investigators, institutional review boards, funding
      agencies, and data safety and monitoring boards. The Common Rule sets out
      requirements that such research must satisfy but no ethical framework to guide
      their application. We provide such an ethical framework, based on the ethical
      concept of the fetus as a patient. We offer criteria for innovation and for Phase
      I and II and then for Phase III clinical trials to improve the health of pregnant
      patients and of fetal patients and also criteria to responsibly manage the
      transition from investigation to clinical practice. Basing ethical criteria for
      research involving pregnant women on the ethical concept of the fetus as a
      patient insulates the proposed ethical framework and therefore research on
      pregnant women from the divisive and politicized concepts and discourses of
      personhood, fetal rights, and unborn child.
FAU - Chervenak, Frank A
AU  - Chervenak FA
AD  - Weill Medical College of Cornell University, New York, NY 10065, USA.
FAU - McCullough, Laurence B
AU  - McCullough LB
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CIN - Am J Bioeth. 2011 May;11(5):W3-7. PMID: 21534136
CIN - Am J Bioeth. 2011 May;11(5):50-2. PMID: 21534152
CIN - Am J Bioeth. 2011 May;11(5):52-4. PMID: 21534153
CIN - Am J Bioeth. 2011 May;11(5):54-6. PMID: 21534154
CIN - Am J Bioeth. 2011 May;11(5):56-7. PMID: 21534155
CIN - Am J Bioeth. 2011 May;11(5):57-60. PMID: 21534156
CIN - Am J Bioeth. 2011 May;11(5):60-2. PMID: 21534157
CIN - Am J Bioeth. 2011 May;11(5):62-4. PMID: 21534158
CIN - Am J Bioeth. 2011 May;11(5):64-5. PMID: 21534159
CIN - Am J Bioeth. 2011 May;11(5):66-8. PMID: 21534160
MH  - Clinical Trials as Topic/*ethics/legislation & jurisprudence
MH  - Ethics Committees, Research
MH  - Ethics, Research
MH  - Female
MH  - Fetal Research/*ethics/legislation & jurisprudence
MH  - Fetal Viability
MH  - Human Experimentation/*ethics/legislation & jurisprudence
MH  - Humans
MH  - *Informed Consent/ethics/legislation & jurisprudence
MH  - *Moral Obligations
MH  - Patients
MH  - *Personhood
MH  - Physician-Patient Relations/*ethics
MH  - Pregnancy
MH  - *Pregnant Women
MH  - *Principle-Based Ethics
MH  - Research Subjects
MH  - Researcher-Subject Relations/*ethics
MH  - Translational Research, Biomedical/*ethics
MH  - United States
EDAT- 2011/05/03 06:00
MHDA- 2011/07/13 06:00
CRDT- 2011/05/03 06:00
PHST- 2011/05/03 06:00 [entrez]
PHST- 2011/05/03 06:00 [pubmed]
PHST- 2011/07/13 06:00 [medline]
AID - 936959997 [pii]
AID - 10.1080/15265161.2011.562595 [doi]
PST - ppublish
SO  - Am J Bioeth. 2011 May;11(5):39-49. doi: 10.1080/15265161.2011.562595.


PMID- 21534146
OWN - NLM
STAT- MEDLINE
DCOM- 20110712
LR  - 20110502
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 11
IP  - 5
DP  - 2011 May
TI  - Social contexts influence ethical considerations of research.
PG  - 24-30
LID - 10.1080/15265161.2011.560338 [doi]
AB  - This article argues that we could improve the design of research protocols by
      developing an awareness of and a responsiveness to the social contexts of all the
      actors in the research enterprise, including subjects, investigators, sponsors,
      and members of the community in which the research will be conducted. "Social
      context" refers to the settings in which the actors are situated, including, but 
      not limited to, their social, economic, political, cultural, and technological
      features. The utility of thinking about social contexts is introduced and
      exemplified by the presentation of a hypothetical case in which one central issue
      is limitation of the probability of injury to subjects by selection of
      individuals who are not expected to live long enough for the known risks of the
      study to become manifest as harms. Benefits of such considerations may include
      enhanced subject satisfaction and cooperation, community acceptance, and improved
      data quality, among other desirable consequences.
FAU - Gordon, Judith B
AU  - Gordon JB
AD  - Yale University School of Medicine, 31 Beach Point Drive, Milford, CT 06460, USA.
FAU - Levine, Robert J
AU  - Levine RJ
FAU - Mazure, Carolyn M
AU  - Mazure CM
FAU - Rubin, Philip E
AU  - Rubin PE
FAU - Schaller, Barry R
AU  - Schaller BR
FAU - Young, John L
AU  - Young JL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
RN  - 0 (AIDS Vaccines)
SB  - IM
CIN - Am J Bioeth. 2011 May;11(5):W1-2. PMID: 21534134
CIN - Am J Bioeth. 2011 May;11(5):31-2. PMID: 21534147
CIN - Am J Bioeth. 2011 May;11(5):33-4. PMID: 21534148
CIN - Am J Bioeth. 2011 May;11(5):35-6. PMID: 21534149
CIN - Am J Bioeth. 2011 May;11(5):37-8. PMID: 21534150
MH  - AIDS Vaccines/administration & dosage/immunology
MH  - Amyotrophic Lateral Sclerosis/complications
MH  - Clinical Trials as Topic/ethics
MH  - Ethics Committees, Research
MH  - Ethics, Research
MH  - HIV Infections/immunology/prevention & control
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - *Mass Media
MH  - *Public Opinion
MH  - *Research Design
MH  - *Research Personnel
MH  - *Research Subjects
MH  - *Social Environment
EDAT- 2011/05/03 06:00
MHDA- 2011/07/13 06:00
CRDT- 2011/05/03 06:00
PHST- 2011/05/03 06:00 [entrez]
PHST- 2011/05/03 06:00 [pubmed]
PHST- 2011/07/13 06:00 [medline]
AID - 936958899 [pii]
AID - 10.1080/15265161.2011.560338 [doi]
PST - ppublish
SO  - Am J Bioeth. 2011 May;11(5):24-30. doi: 10.1080/15265161.2011.560338.


PMID- 21534136
OWN - NLM
STAT- MEDLINE
DCOM- 20110712
LR  - 20110502
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 11
IP  - 5
DP  - 2011 May
TI  - The fetus as a patient and the ethics of human subjects research: response to
      commentaries on "An ethically justified framework for clinical investigation to
      benefit pregnant and fetal patients".
PG  - W3-7
LID - 10.1080/15265161.2011.576939 [doi]
FAU - McCullough, Laurence B
AU  - McCullough LB
AD  - Center for Medical Ethics and Health Policy, Baylor College of Medicine, One
      Baylor Plaza MS 420, Houston, TX 77030-3411, USA. mccullou@bcm.edu
FAU - Chervenak, Frank A
AU  - Chervenak FA
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2011 May;11(5):39-49. PMID: 21534151
MH  - Clinical Trials as Topic/*ethics
MH  - Female
MH  - Fetal Death
MH  - Fetal Research/ethics
MH  - *Fetus
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Informed Consent/ethics
MH  - *Moral Obligations
MH  - *Patients
MH  - Physician-Patient Relations/ethics
MH  - Pregnancy
MH  - *Pregnant Women
MH  - Prenatal Exposure Delayed Effects
MH  - *Research Subjects
MH  - Researcher-Subject Relations/ethics
MH  - Risk
MH  - Truth Disclosure
EDAT- 2011/05/03 06:00
MHDA- 2011/07/13 06:00
CRDT- 2011/05/03 06:00
PHST- 2011/05/03 06:00 [entrez]
PHST- 2011/05/03 06:00 [pubmed]
PHST- 2011/07/13 06:00 [medline]
AID - 936960236 [pii]
AID - 10.1080/15265161.2011.576939 [doi]
PST - ppublish
SO  - Am J Bioeth. 2011 May;11(5):W3-7. doi: 10.1080/15265161.2011.576939.


PMID- 21534134
OWN - NLM
STAT- MEDLINE
DCOM- 20110712
LR  - 20110502
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 11
IP  - 5
DP  - 2011 May
TI  - Response to open peer commentaries on "Social contexts influence ethical
      considerations of research".
PG  - W1-2
LID - 10.1080/15265161.2011.576936 [doi]
FAU - Levine, Robert J
AU  - Levine RJ
AD  - Yale University, 31 Beach Point Drive, Milford, CT 06460, USA.
      levinerj@sbcglobal.net
FAU - Gordon, Judith B
AU  - Gordon JB
FAU - Mazure, Carolyn M
AU  - Mazure CM
FAU - Rubin, Philip E
AU  - Rubin PE
FAU - Schaller, Barry R
AU  - Schaller BR
FAU - Young, John L
AU  - Young JL
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
RN  - 0 (AIDS Vaccines)
SB  - IM
CON - Am J Bioeth. 2011 May;11(5):24-30. PMID: 21534146
MH  - AIDS Vaccines
MH  - Amyotrophic Lateral Sclerosis/complications
MH  - Clinical Trials as Topic/*ethics
MH  - Ethics Committees, Research
MH  - Ethics, Research
MH  - HIV Infections/prevention & control
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Patents as Topic
MH  - *Public Opinion
MH  - *Research Design
MH  - Research Personnel
MH  - Research Subjects
MH  - *Social Environment
MH  - United States
EDAT- 2011/05/03 06:00
MHDA- 2011/07/13 06:00
CRDT- 2011/05/03 06:00
PHST- 2011/05/03 06:00 [entrez]
PHST- 2011/05/03 06:00 [pubmed]
PHST- 2011/07/13 06:00 [medline]
AID - 936959039 [pii]
AID - 10.1080/15265161.2011.576936 [doi]
PST - ppublish
SO  - Am J Bioeth. 2011 May;11(5):W1-2. doi: 10.1080/15265161.2011.576936.


PMID- 21534067
OWN - NLM
STAT- MEDLINE
DCOM- 20110826
LR  - 20110502
IS  - 1528-6916 (Electronic)
IS  - 0885-4726 (Linking)
VI  - 17
IP  - 1-2
DP  - 2011
TI  - Ethical issues in case study publication: "making our case(s)" ethically.
PG  - 55-74
LID - 10.1080/08854726.2011.559855 [doi]
AB  - As chaplains develop richly detailed case studies for publication, ethical
      questions about case study construction and publication are emerging. Concerns
      about seeking patients' permission to publish material about them suggest
      additional questions and raise broad confidentiality and privacy issues.
      Confidentiality-related practices in health care and psychotherapy provide the
      most extensive guidance for chaplains, but healthcare chaplaincy has roots in
      religious and professional traditions with distinct notions of confidentiality
      that deserve consideration. Single case studies do not appear to be "research"
      requiring informed consent, yet their publication exposes patients to some risk
      of harm. Obtaining the patient's/"case study subject's" permission to publish,
      disguising non-essential information, and allowing the patient to review the case
      study can mitigate the risks. Striking a balance between protecting patients and 
      providing sufficient detail to make case studies useful is a central ethical
      challenge of case study publication.
FAU - McCurdy, David B
AU  - McCurdy DB
AD  - Advocate Health Care, Park Ridge, Illinois 60068, USA.
      David.McCurdy@advocatehealth.com
FAU - Fitchett, George
AU  - Fitchett G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Health Care Chaplain
JT  - Journal of health care chaplaincy
JID - 8800764
MH  - Chaplaincy Service, Hospital/*ethics/organization & administration
MH  - Confidentiality/*ethics
MH  - Humans
MH  - Informed Consent/ethics
MH  - Organizational Case Studies/*ethics
MH  - Pastoral Care
MH  - Professional-Patient Relations
MH  - Publishing/*ethics
EDAT- 2011/05/03 06:00
MHDA- 2011/08/30 06:00
CRDT- 2011/05/03 06:00
PHST- 2011/05/03 06:00 [entrez]
PHST- 2011/05/03 06:00 [pubmed]
PHST- 2011/08/30 06:00 [medline]
AID - 936960642 [pii]
AID - 10.1080/08854726.2011.559855 [doi]
PST - ppublish
SO  - J Health Care Chaplain. 2011;17(1-2):55-74. doi: 10.1080/08854726.2011.559855.


PMID- 21533834
OWN - NLM
STAT- MEDLINE
DCOM- 20120727
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 18
IP  - 1
DP  - 2012 Mar
TI  - Engineering and the problem of moral overload.
PG  - 143-55
LID - 10.1007/s11948-011-9277-z [doi]
AB  - When thinking about ethics, technology is often only mentioned as the source of
      our problems, not as a potential solution to our moral dilemmas. When thinking
      about technology, ethics is often only mentioned as a constraint on developments,
      not as a source and spring of innovation. In this paper, we argue that ethics can
      be the source of technological development rather than just a constraint and
      technological progress can create moral progress rather than just moral problems.
      We show this by an analysis of how technology can contribute to the solution of
      so-called moral overload or moral dilemmas. Such dilemmas typically create a
      moral residue that is the basis of a second-order principle that tells us to
      reshape the world so that we can meet all our moral obligations. We can do so,
      among other things, through guided technological innovation.
CI  - (c) The Author(s) 2011. This article is published with open access at
      Springerlink.com
FAU - Van den Hoven, Jeroen
AU  - Van den Hoven J
AD  - Section of Philosophy, Faculty of Technology, Policy and Management, Delft
      University of Technology, P.O. Box 5015, 2600 GA Delft, The Netherlands.
FAU - Lokhorst, Gert-Jan
AU  - Lokhorst GJ
FAU - Van de Poel, Ibo
AU  - Van de Poel I
LA  - eng
PT  - Journal Article
DEP - 20110501
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Engineering/*ethics
MH  - Humans
MH  - *Moral Obligations
MH  - *Problem Solving
MH  - Technology/*ethics
PMC - PMC3275721
EDAT- 2011/05/03 06:00
MHDA- 2012/07/28 06:00
CRDT- 2011/05/03 06:00
PHST- 2010/11/10 00:00 [received]
PHST- 2011/04/17 00:00 [accepted]
PHST- 2011/05/03 06:00 [entrez]
PHST- 2011/05/03 06:00 [pubmed]
PHST- 2012/07/28 06:00 [medline]
AID - 10.1007/s11948-011-9277-z [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2012 Mar;18(1):143-55. doi: 10.1007/s11948-011-9277-z. Epub 2011 
      May 1.


PMID- 21533793
OWN - NLM
STAT- MEDLINE
DCOM- 20120727
LR  - 20211020
IS  - 1432-0460 (Electronic)
IS  - 0179-051X (Linking)
VI  - 27
IP  - 1
DP  - 2012 Mar
TI  - Promoting shared decision-making in rehabilitation: development of a framework
      for situations when patients with Dysphagia refuse diet modification recommended 
      by the treating team.
PG  - 81-7
LID - 10.1007/s00455-011-9341-5 [doi]
AB  - To address the risks of aspiration pneumonia, patients with dysphagia may be
      prescribed a modified diet. The goal of diet modification is to decrease the risk
      of patients aspirating food due to their diminished swallowing reflex. Some
      patients may not accept diet modification or may not adhere to the treatments
      identified by the interdisciplinary team. Such scenarios may result in important 
      moral uncertainty and concern for clinicians. As a result of several ethics
      consultations related to this issue, a working group of the Clinical Ethics
      Committee at the Jewish Rehabilitation Hospital in Laval, Quebec, Canada,
      developed a framework for responding to situations when patients do not adhere to
      recommended diet modification. The goal of this tool is to facilitate discussion 
      and collaboration between clinicians and patients, to clarify assumed versus real
      risk, and to promote shared decision-making in dysphagia care. In this article we
      examine the clinical context of diet modification for patients with dysphagia in 
      rehabilitation hospitals, explore ethical aspects of this topic, present the
      clinical algorithm, and discuss our experience with developing and piloting this 
      tool.
FAU - Kaizer, Franceen
AU  - Kaizer F
AD  - Jewish Rehabilitation Hospital, Laval, Canada. franceen_kaizer@ssss.gouv.qc.ca
FAU - Spiridigliozzi, Anna-Maria
AU  - Spiridigliozzi AM
FAU - Hunt, Matthew R
AU  - Hunt MR
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110501
PL  - United States
TA  - Dysphagia
JT  - Dysphagia
JID - 8610856
SB  - IM
MH  - Algorithms
MH  - *Decision Support Techniques
MH  - Deglutition Disorders/*diet therapy/rehabilitation
MH  - Humans
MH  - *Patient Care Team/ethics
MH  - Patient Compliance
MH  - *Patient Participation
MH  - Practice Guidelines as Topic
MH  - *Professional-Patient Relations/ethics
MH  - Quebec
MH  - Rehabilitation Centers
MH  - *Treatment Refusal/ethics
EDAT- 2011/05/03 06:00
MHDA- 2012/07/28 06:00
CRDT- 2011/05/03 06:00
PHST- 2010/05/05 00:00 [received]
PHST- 2011/03/26 00:00 [accepted]
PHST- 2011/05/03 06:00 [entrez]
PHST- 2011/05/03 06:00 [pubmed]
PHST- 2012/07/28 06:00 [medline]
AID - 10.1007/s00455-011-9341-5 [doi]
PST - ppublish
SO  - Dysphagia. 2012 Mar;27(1):81-7. doi: 10.1007/s00455-011-9341-5. Epub 2011 May 1.


PMID- 21533275
OWN - NLM
STAT- MEDLINE
DCOM- 20110830
LR  - 20211020
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 6
IP  - 4
DP  - 2011 Apr 12
TI  - Quality of reporting on the vegetative state in Italian newspapers. The case of
      Eluana Englaro.
PG  - e18706
LID - 10.1371/journal.pone.0018706 [doi]
AB  - BACKGROUND: Media coverage of the vegetative state (VS) includes refutations of
      the VS diagnosis and describes behaviors inconsistent with VS. We used a quality 
      score to assess the reporting in articles describing the medical characteristics 
      of VS in Italian newspapers. METHODOLOGY/PRINCIPAL FINDINGS: Our search covered a
      7-month period from July 1, 2008, to February 28, 2009, using the online
      searchable databases of four major Italian newspapers: Corriere della Sera, La
      Repubblica, La Stampa, and Avvenire. Medical reporting was judged as complete if 
      three core VS characteristics were described: patient unawareness of self and the
      environment, preserved wakefulness (eyes open), and spontaneous respiration
      (artificial ventilator not needed). We retrieved 2,099 articles, and 967 were
      dedicated to VS. Of these, 853 (88.2%) were non-medical and mainly focused on
      describing the political, legal, and ethical aspects of VS. Of the 114 (11.8%)
      medical articles, 53 (5.5%) discussed other medical problems such as death by
      dehydration, artificial nutrition, neuroimaging, brain death, or uterine
      hemorrhage, and 61 (6.3%) described VS. Of these 61, only 18 (1.9%) reported all 
      three CORE characteristics and were judged complete. We found no differences
      among the four investigated newspapers (Fisher's exact = 0.798), and incomplete
      articles were equally distributed between journalistic pieces and expert opinions
      (chi(2) = 1.8854, P = 0.170). Incorrect descriptions of VS were significantly
      more common among incomplete articles (13 of 43 vs. 1 of 18; Fisher's exact P =
      0.047). CONCLUSIONS/SIGNIFICANCE: Core VS characteristics are rarely reported in 
      Italian newspaper articles, which can alter adequate comprehension of new
      developments and (mis)inform political, legal, and ethical decisions.
FAU - Latronico, Nicola
AU  - Latronico N
AD  - Department of Neuroanesthesia and Neurointensive Care, University of Brescia,
      Spedali Civili, Brescia, Italy. nicola.latronico@med.unibs.it
FAU - Manenti, Ottavia
AU  - Manenti O
FAU - Baini, Luca
AU  - Baini L
FAU - Rasulo, Frank A
AU  - Rasulo FA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110412
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Humans
MH  - Italy
MH  - *Mass Media
MH  - Persistent Vegetative State/*physiopathology
PMC - PMC3075268
EDAT- 2011/05/03 06:00
MHDA- 2011/08/31 06:00
CRDT- 2011/05/03 06:00
PHST- 2010/08/23 00:00 [received]
PHST- 2011/03/16 00:00 [accepted]
PHST- 2011/05/03 06:00 [entrez]
PHST- 2011/05/03 06:00 [pubmed]
PHST- 2011/08/31 06:00 [medline]
AID - 10.1371/journal.pone.0018706 [doi]
PST - epublish
SO  - PLoS One. 2011 Apr 12;6(4):e18706. doi: 10.1371/journal.pone.0018706.


PMID- 21532816
OWN - NLM
STAT- MEDLINE
DCOM- 20110727
LR  - 20211020
IS  - 0008-5286 (Print)
IS  - 0008-5286 (Linking)
VI  - 52
IP  - 2
DP  - 2011 Feb
TI  - Veterinary medical ethics. An ethicist's commentary on the case of the client who
      abuses disease surveillance results.
PG  - 113-4
FAU - Rollin, Bernard E
AU  - Rollin BE
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Vet J
JT  - The Canadian veterinary journal = La revue veterinaire canadienne
JID - 0004653
SB  - IM
MH  - Animal Diseases/*epidemiology/transmission
MH  - Animals
MH  - Humans
MH  - Mandatory Reporting/*ethics
MH  - Prevalence
MH  - Public Health
MH  - Sentinel Surveillance/*veterinary
MH  - Veterinary Medicine/*ethics
PMC - PMC3022446
EDAT- 2011/05/03 06:00
MHDA- 2011/07/28 06:00
CRDT- 2011/05/03 06:00
PHST- 2011/05/03 06:00 [entrez]
PHST- 2011/05/03 06:00 [pubmed]
PHST- 2011/07/28 06:00 [medline]
PST - ppublish
SO  - Can Vet J. 2011 Feb;52(2):113-4.


PMID- 21532648
OWN - NLM
STAT- MEDLINE
DCOM- 20110915
LR  - 20191112
IS  - 2340-3527 (Electronic)
IS  - 1137-6627 (Linking)
VI  - 34
IP  - 1
DP  - 2011 Jan-Apr
TI  - [Confidentiality and the medical record. Ethical-legal considerations].
PG  - 73-82
AB  - Confidentiality is a key aspect in the relationship between health professionals 
      and patients. It involves the cession by the patient of a reserved part of
      herself and the ethical principles of autonomy and non-maleficency that are
      closely linked to its preservation. There are also numerous legal regulations
      that make professional secrecy obligatory, in some cases imposing hard sanctions 
      that are often not known about. As the medical record is the document where the
      relationship with the patient is recorded, it requires extraordinary protection
      due to the especially sensitive nature of the information it contains. It should 
      be compulsory that the professional who works with it should know some basic
      aspects of the fundamental laws that regulate it in different aspects. This
      article reviews questions that at times are only known in the abstract, but that 
      are contained in the legal regulations, such as ownership of the medical record, 
      subjective annotations, its custody and rectification or who can have access to
      it and why.
FAU - Antomas, J
AU  - Antomas J
AD  - Unidad de Hospitalizacion Psiquiatrica A, Complejo Hospitalario de Navarra,
      Pamplona, Spain. xabier.antomas.oses@navarra.es
FAU - Huarte del Barrio, S
AU  - Huarte del Barrio S
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Confidencialidad e historia clinica. Consideraciones etico-legales.
PL  - Spain
TA  - An Sist Sanit Navar
JT  - Anales del sistema sanitario de Navarra
JID - 9710381
SB  - IM
MH  - Confidentiality/*ethics/*legislation & jurisprudence
MH  - Medical Records/*legislation & jurisprudence
EDAT- 2011/05/03 06:00
MHDA- 2011/09/16 06:00
CRDT- 2011/05/03 06:00
PHST- 2011/05/03 06:00 [entrez]
PHST- 2011/05/03 06:00 [pubmed]
PHST- 2011/09/16 06:00 [medline]
AID - 10.4321/s1137-66272011000100008 [doi]
PST - ppublish
SO  - An Sist Sanit Navar. 2011 Jan-Apr;34(1):73-82. doi:
      10.4321/s1137-66272011000100008.


PMID- 21532128
OWN - NLM
STAT- MEDLINE
DCOM- 20110818
LR  - 20211020
IS  - 1529-8795 (Electronic)
IS  - 0031-5982 (Linking)
VI  - 54
IP  - 2
DP  - 2011 Spring
TI  - Experimental arrest of cerebral blood flow in human subjects: the red wing
      studies revisited.
PG  - 121-31
LID - 10.1353/pbm.2011.0018 [doi]
AB  - Loss of consciousness in pilots during rapid ascent after bombing missions was a 
      major problem in World War II, and experiments were undertaken to study the cause
      of this phenomenon. Postulating impaired cerebral blood flow as a likely
      mechanism, the investigators developed a neck device, the KRA Cuff, which when
      inflated could shut off blood supply to the brain. With cessation of blood flow
      for up to 100 seconds, the investigators observed a sequence of responses,
      including unconsciousness, followed by dilated pupils, tonic/clonic movements,
      loss of bladder and eventually bowel control, and appearance of pathological
      reflexes. This study, carried out in prisoners and patients with schizophrenia in
      1941-42, largely disappeared from public discourse for a number of years. It has 
      received occasional attention subsequently and been considered controversial.
      Recently discovered records, including extensive written and photographic data
      from the studies, shed new light on the methods and motives of the research team.
      We describe here this new information and its implications for the scientific and
      ethical assessment of the study.
FAU - Smith, Brian A
AU  - Smith BA
AD  - Autonomic Dysfunction Center,Vanderbilt University, Nashville, TN 37232-2195,
      USA.
FAU - Clayton, Ellen Wright
AU  - Clayton EW
FAU - Robertson, David
AU  - Robertson D
LA  - eng
GR  - U54 NS065736/NS/NINDS NIH HHS/United States
GR  - P01 HL056693/HL/NHLBI NIH HHS/United States
GR  - UL1RR024975/RR/NCRR NIH HHS/United States
GR  - UL1 RR024975/RR/NCRR NIH HHS/United States
GR  - R01 HL071784/HL/NHLBI NIH HHS/United States
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Perspect Biol Med
JT  - Perspectives in biology and medicine
JID - 0401132
SB  - IM
MH  - Aircraft
MH  - Altitude Sickness/physiopathology
MH  - Biomedical Research/*history
MH  - Blinking
MH  - Blood Circulation Time
MH  - Brain/*blood supply
MH  - *Cerebrovascular Circulation
MH  - Ethics, Medical
MH  - History, 20th Century
MH  - Humans
MH  - Hypoxia, Brain/*physiopathology
MH  - Physiology/*history
MH  - Pressure
MH  - Prisoners
MH  - Schizophrenia/physiopathology
MH  - Stress, Physiological
MH  - Unconsciousness/physiopathology
MH  - World War II
PMC - PMC3848716
MID - NIHMS522193
EDAT- 2011/05/03 06:00
MHDA- 2011/08/19 06:00
CRDT- 2011/05/03 06:00
PHST- 2011/05/03 06:00 [entrez]
PHST- 2011/05/03 06:00 [pubmed]
PHST- 2011/08/19 06:00 [medline]
AID - S1529879511200012 [pii]
AID - 10.1353/pbm.2011.0018 [doi]
PST - ppublish
SO  - Perspect Biol Med. 2011 Spring;54(2):121-31. doi: 10.1353/pbm.2011.0018.


PMID- 21531909
OWN - NLM
STAT- MEDLINE
DCOM- 20110824
LR  - 20110502
IS  - 1708-8283 (Electronic)
IS  - 0883-0738 (Linking)
VI  - 26
IP  - 5
DP  - 2011 May
TI  - Sterilization for individuals with mental disabilities: the other half of the
      equation.
PG  - 649-50
LID - 10.1177/0883073811402075 [doi]
AB  - Medical ethics can be defined as the study of moral values and judgments as they 
      apply to medicine. Healthcare providers, or for that matter all who make
      contributions to the field of medicine, are regularly confronted by ethical
      dilemmas. Like other predicaments, ethical dilemmas require thoughtful
      consideration. The overarching goal of Ethical Crossroads is to provide a forum
      for opinions on a contemporary ethical challenge that, at least tangentially,
      impacts the practice of child neurology.
FAU - Weisleder, Pedro
AU  - Weisleder P
AD  - Nationwide Children's Hospital, Columbus, Ohio, USA. weisleder.1@osu.edu
LA  - eng
PT  - Introductory Journal Article
PL  - United States
TA  - J Child Neurol
JT  - Journal of child neurology
JID - 8606714
SB  - IM
MH  - *Dissent and Disputes
MH  - *Ethics, Medical
MH  - Humans
MH  - *Mental Disorders
MH  - *Sterilization, Reproductive
EDAT- 2011/05/03 06:00
MHDA- 2011/08/25 06:00
CRDT- 2011/05/03 06:00
PHST- 2011/05/03 06:00 [entrez]
PHST- 2011/05/03 06:00 [pubmed]
PHST- 2011/08/25 06:00 [medline]
AID - 26/5/649 [pii]
AID - 10.1177/0883073811402075 [doi]
PST - ppublish
SO  - J Child Neurol. 2011 May;26(5):649-50. doi: 10.1177/0883073811402075.


PMID- 21531885
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20211020
IS  - 1942-5546 (Electronic)
IS  - 0025-6196 (Linking)
VI  - 86
IP  - 5
DP  - 2011 May
TI  - Ethics and values in clinical practice: whom do they help?
PG  - 421-4
LID - 10.4065/mcp.2010.0781 [doi]
FAU - Gabel, Stewart
AU  - Gabel S
AD  - Child and Family Services, New York State Office of Mental Health, 44 Holland
      Ave, Albany, NY 12208, USA. cocfsxg@omh.state.ny.us
LA  - eng
PT  - Journal Article
PL  - England
TA  - Mayo Clin Proc
JT  - Mayo Clinic proceedings
JID - 0405543
SB  - IM
MH  - *Burnout, Professional
MH  - Curriculum
MH  - Education, Medical
MH  - *Ethics, Institutional
MH  - *Ethics, Medical/education
MH  - Hippocratic Oath
MH  - Humans
MH  - Morals
MH  - Organizational Culture
MH  - Physicians/*psychology
MH  - Risk Factors
MH  - *Social Values
MH  - United States
MH  - Workload/psychology
PMC - PMC3084645
EDAT- 2011/05/03 06:00
MHDA- 2011/07/27 06:00
CRDT- 2011/05/03 06:00
PHST- 2011/05/03 06:00 [entrez]
PHST- 2011/05/03 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
AID - S0025-6196(11)60032-3 [pii]
AID - 10.4065/mcp.2010.0781 [doi]
PST - ppublish
SO  - Mayo Clin Proc. 2011 May;86(5):421-4. doi: 10.4065/mcp.2010.0781.


PMID- 21531519
OWN - NLM
STAT- MEDLINE
DCOM- 20121024
LR  - 20120601
IS  - 1872-7727 (Electronic)
IS  - 0720-048X (Linking)
VI  - 81
IP  - 7
DP  - 2012 Jul
TI  - Investigation of the role of computed tomography as an adjunct to autopsy in the 
      evaluation of stillbirth.
PG  - 1667-75
LID - 10.1016/j.ejrad.2011.03.093 [doi]
AB  - INTRODUCTION: The number of parents agreeing to autopsy following stillbirth is
      declining, which has undermined clinicians' ability to assess causes of
      intrauterine death and can impact counselling regarding recurrence. Post-mortem
      radiological imaging is a potential alternative method of investigating perinatal
      loss. The aim of this study was to assess the role of multi-detector computed
      tomography (MDCT) in the investigation of stillbirth. STUDY DESIGN: Following
      ethical approval and written consent, parents were offered MDCT of the stillborn 
      infant. MDCT was performed with 3D reconstruction, and images were analysed for
      image quality, anthropomorphic measurements and pathologic findings. Body part
      and organ-specific measurements were performed; including head, chest and
      abdominal circumferences, and muscle and liver mass was also measured. Findings
      were correlated with obstetric history, post-mortem skeletal survey (plain
      radiography), and formal autopsy. RESULTS: Fourteen third-trimester stillborn
      infants were scanned. Image quality was moderate to excellent for most body
      structures. CT was better than plain radiography for imaging skeletal structures 
      and large solid organs and demonstrated a range of pathologies including renal
      vein thrombosis, mesenteric calcification and skeletal hyperostosis that were not
      seen on plain radiographs. MDCT did not overlook autopsy findings and provided
      some additional information. CONCLUSION: This study confirms the feasibility of
      MDCT in the investigation of third trimester stillbirth. MDCT image quality is
      acceptable and the examination can demonstrate a range of anatomic and pathologic
      findings. Initially, its value may be as an important adjunct to conventional
      autopsy.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - O'Donoghue, Keelin
AU  - O'Donoghue K
AD  - Anu Research Centre, Department of Obstetrics and Gynaecology, University College
      Cork, Cork University Maternity Hospital, Wilton, Cork, Ireland.
      k.odonoghue@ucc.ie
FAU - O'Regan, Kevin N
AU  - O'Regan KN
FAU - Sheridan, Carmel P
AU  - Sheridan CP
FAU - O'Connor, Owen J
AU  - O'Connor OJ
FAU - Benson, Jodie
AU  - Benson J
FAU - McWilliams, Sebastian
AU  - McWilliams S
FAU - Moore, Niamh
AU  - Moore N
FAU - Murphy, Mary J
AU  - Murphy MJ
FAU - Chopra, Raj
AU  - Chopra R
FAU - Higgins, John R
AU  - Higgins JR
FAU - Maher, Michael M
AU  - Maher MM
LA  - eng
PT  - Journal Article
DEP - 20110430
PL  - Ireland
TA  - Eur J Radiol
JT  - European journal of radiology
JID - 8106411
SB  - IM
MH  - Autopsy/*methods
MH  - Cause of Death
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Pregnancy
MH  - Pregnancy Trimester, Third
MH  - Radiographic Image Interpretation, Computer-Assisted
MH  - Retrospective Studies
MH  - Statistics, Nonparametric
MH  - *Stillbirth
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2011/05/03 06:00
MHDA- 2012/10/25 06:00
CRDT- 2011/05/03 06:00
PHST- 2011/01/22 00:00 [received]
PHST- 2011/03/24 00:00 [revised]
PHST- 2011/03/30 00:00 [accepted]
PHST- 2011/05/03 06:00 [entrez]
PHST- 2011/05/03 06:00 [pubmed]
PHST- 2012/10/25 06:00 [medline]
AID - S0720-048X(11)00367-6 [pii]
AID - 10.1016/j.ejrad.2011.03.093 [doi]
PST - ppublish
SO  - Eur J Radiol. 2012 Jul;81(7):1667-75. doi: 10.1016/j.ejrad.2011.03.093. Epub 2011
      Apr 30.


PMID- 21531517
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20110516
IS  - 1873-4111 (Electronic)
IS  - 0378-5122 (Linking)
VI  - 69
IP  - 2
DP  - 2011 Jun
TI  - Sensor technology for smart homes.
PG  - 131-6
LID - 10.1016/j.maturitas.2011.03.016 [doi]
AB  - A smart home is a residence equipped with technology that observes the residents 
      and provides proactive services. Most recently, it has been introduced as a
      potential solution to support independent living of people with disabilities and 
      older adults, as well as to relieve the workload from family caregivers and
      health providers. One of the key supporting features of a smart home is its
      ability to monitor the activities of daily living and safety of residents, and in
      detecting changes in their daily routines. With the availability of inexpensive
      low-power sensors, radios, and embedded processors, current smart homes are
      typically equipped with a large amount of networked sensors which collaboratively
      process and make deductions from the acquired data on the state of the home as
      well as the activities and behaviors of its residents. This article reviews
      sensor technology used in smart homes with a focus on direct environment sensing 
      and infrastructure mediated sensing. The article also points out the strengths
      and limitations of different sensor technologies, as well as discusses challenges
      and opportunities from clinical, technical, and ethical perspectives. It is
      recommended that sensor technologies for smart homes address actual needs of all 
      stake holders including end users, their family members and caregivers, and their
      doctors and therapists. More evidence on the appropriateness, usefulness, and
      cost benefits analysis of sensor technologies for smart homes is necessary before
      these sensors should be widely deployed into real-world residential settings and 
      successfully integrated into everyday life and health care services.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Ding, Dan
AU  - Ding D
AD  - Department of Rehabilitation Science and Technology, University of Pittsburgh,
      Pittsburgh, PA 15260, USA. dad5@pitt.edu
FAU - Cooper, Rory A
AU  - Cooper RA
FAU - Pasquina, Paul F
AU  - Pasquina PF
FAU - Fici-Pasquina, Lavinia
AU  - Fici-Pasquina L
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20110504
PL  - Ireland
TA  - Maturitas
JT  - Maturitas
JID - 7807333
SB  - IM
MH  - Aged
MH  - Disabled Persons
MH  - *Electrical Equipment and Supplies
MH  - Environment
MH  - Facility Design and Construction
MH  - Health Services Needs and Demand
MH  - *Home Care Services
MH  - *Housing
MH  - Humans
MH  - *Independent Living
MH  - Monitoring, Ambulatory/*instrumentation
MH  - *Telemetry
EDAT- 2011/05/03 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/05/03 06:00
PHST- 2011/03/07 00:00 [received]
PHST- 2011/03/11 00:00 [accepted]
PHST- 2011/05/03 06:00 [entrez]
PHST- 2011/05/03 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0378-5122(11)00098-3 [pii]
AID - 10.1016/j.maturitas.2011.03.016 [doi]
PST - ppublish
SO  - Maturitas. 2011 Jun;69(2):131-6. doi: 10.1016/j.maturitas.2011.03.016. Epub 2011 
      May 4.


PMID- 21531268
OWN - NLM
STAT- MEDLINE
DCOM- 20110527
LR  - 20150616
IS  - 1474-547X (Electronic)
IS  - 0140-6736 (Linking)
VI  - 377
IP  - 9776
DP  - 2011 Apr 30
TI  - Live case demonstrations: patient safety, ethics, consent, and conflicts.
PG  - 1539-41
LID - 10.1016/S0140-6736(11)60357-7 [doi]
FAU - Kallmes, David F
AU  - Kallmes DF
AD  - Mayo Clinic, Rochester, MN 55902, USA. kallmes.david@mayo.edu
FAU - Cloft, Harry J
AU  - Cloft HJ
FAU - Molyneux, Andrew
AU  - Molyneux A
FAU - Burger, Ingrid
AU  - Burger I
FAU - Brinjikji, Waleed
AU  - Brinjikji W
FAU - Murphy, Kieren P
AU  - Murphy KP
LA  - eng
PT  - Journal Article
PL  - England
TA  - Lancet
JT  - Lancet (London, England)
JID - 2985213R
SB  - IM
MH  - *Conflict of Interest
MH  - Endovascular Procedures/*education
MH  - *Ethics, Medical
MH  - Humans
MH  - *Informed Consent
MH  - *Safety
MH  - Surgical Procedures, Operative/*education
EDAT- 2011/05/03 06:00
MHDA- 2011/05/28 06:00
CRDT- 2011/05/03 06:00
PHST- 2011/05/03 06:00 [entrez]
PHST- 2011/05/03 06:00 [pubmed]
PHST- 2011/05/28 06:00 [medline]
AID - S0140-6736(11)60357-7 [pii]
AID - 10.1016/S0140-6736(11)60357-7 [doi]
PST - ppublish
SO  - Lancet. 2011 Apr 30;377(9776):1539-41. doi: 10.1016/S0140-6736(11)60357-7.


PMID- 21531154
OWN - NLM
STAT- MEDLINE
DCOM- 20111004
LR  - 20220411
IS  - 1096-0961 (Electronic)
IS  - 1079-9796 (Linking)
VI  - 47
IP  - 1
DP  - 2011 Jun 15
TI  - Oral chelators in transfusion-dependent thalassemia major patients may prevent or
      reverse iron overload complications.
PG  - 33-40
LID - 10.1016/j.bcmd.2011.03.007 [doi]
AB  - Combined chelation treatment may be a better approach for transfusion-dependent
      thalassemia major patients with iron overload complications because of increased 
      efficacy. Combination therapy with desferrioxamine and deferiprone has already
      been reported to improve survival dramatically by reversing cardiac dysfunction
      and other endocrine complications. Some patients have intolerance or
      inconvenience to parenteral desferrioxamine. The hypothesis of this study was
      that combining two oral chelators, deferiprone and deferasirox, might lead to
      similar results. Following approval by the hospital ethical committee and a
      written informed consent from each patient, 16 patients who fulfilled the
      criteria participated in a study protocol for a period of up to 2 years. Efficacy
      measures analysis demonstrated a statistically significant decrease of total body
      iron load as estimated by serum ferritin, LIC and MRI T2* indices. Regarding the 
      safety assessment, the incidence of adverse events was minor compared to the
      associated toxicity of monotherapy of each drug. No new onset of iron
      overload-related complications was demonstrated. A reversal of cardiac
      dysfunction was observed in 2/4 patients, while the mean LVEF increased
      significantly. Regarding endocrine assessment, in 2/8 patients with impaired
      glucose tolerance, we noted a significant decrease in the mean 2h glucose in
      OGTT. Additionally an improvement in gonadal function was observed and one male
      and one female gave birth to two healthy children without hormonal stimulation.
      Combined oral chelation in thalassemia offers the promise of easier
      administration, better compliance and may lead to an improvement of patient
      quality of life by preventing or even reversing iron overload complications.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Farmaki, Kallistheni
AU  - Farmaki K
AD  - Thalassemia Unit, General Hospital of Corinth, 1 Dervenakion, Corinth, Greece.
      kallistheni.farmaki@gmail.com
FAU - Tzoumari, Ioanna
AU  - Tzoumari I
FAU - Pappa, Christina
AU  - Pappa C
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20110429
PL  - United States
TA  - Blood Cells Mol Dis
JT  - Blood cells, molecules & diseases
JID - 9509932
RN  - 0 (Blood Glucose)
RN  - 0 (Iron Chelating Agents)
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - Administration, Oral
MH  - Adult
MH  - Blood Glucose/metabolism
MH  - Female
MH  - Gonads/drug effects
MH  - Heart/drug effects
MH  - Heart Function Tests
MH  - Humans
MH  - Iron/metabolism
MH  - Iron Chelating Agents/pharmacology/*therapeutic use
MH  - *Iron Overload/drug therapy/etiology/prevention & control
MH  - Male
MH  - Middle Aged
MH  - Thyroid Gland/drug effects
MH  - *Transfusion Reaction
MH  - Young Adult
MH  - beta-Thalassemia/*complications/drug therapy/*therapy
EDAT- 2011/05/03 06:00
MHDA- 2011/10/05 06:00
CRDT- 2011/05/03 06:00
PHST- 2011/03/10 00:00 [received]
PHST- 2011/03/19 00:00 [revised]
PHST- 2011/03/21 00:00 [accepted]
PHST- 2011/05/03 06:00 [entrez]
PHST- 2011/05/03 06:00 [pubmed]
PHST- 2011/10/05 06:00 [medline]
AID - S1079-9796(11)00092-1 [pii]
AID - 10.1016/j.bcmd.2011.03.007 [doi]
PST - ppublish
SO  - Blood Cells Mol Dis. 2011 Jun 15;47(1):33-40. doi: 10.1016/j.bcmd.2011.03.007.
      Epub 2011 Apr 29.


PMID- 21531020
OWN - NLM
STAT- MEDLINE
DCOM- 20111103
LR  - 20181201
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 74
IP  - 6
DP  - 2011 Sep
TI  - The use of Eugenol and electro-narcosis as anaesthetics: transcriptional impacts 
      on the European eel (Anguilla anguilla L.).
PG  - 1573-7
LID - 10.1016/j.ecoenv.2011.04.009 [doi]
AB  - Ecotoxicological studies aim to assess the potential environmental risks of
      various products. This implies the use of various biological models and tests on 
      live animals. In case of handling fish and mammals, ethical rules have to be
      respected. The use of anaesthesia is considered to be the best way to ensure
      animal welfare. Eugenol and electro-narcosis are among the most popular chemical 
      and physical anaesthetics used in fisheries and by field biologists. In this
      study, the genetic and endocrine impacts of these anaesthetics were assessed in
      order to establish whether the use of such methods could skew the results of
      ecotoxicological studies. Twenty yellow European eels (Anguilla anguilla) were
      submitted to Eugenol (50mg/L) and electro-narcosis until they reached a level of 
      deep anaesthesia, while 20 other eels were kept aware. Five anaesthetized and
      five unanaesthetized eels were sacrificed and analysed directly after treatment
      and after 1, 7 and 21 days of recovery. At the brain level, Eugenol triggered an 
      increase in the transcription level of genes encoding proteins involved in
      oxidative stress responses (catalase expression 2.5-fold, mitochondrial
      superoxide dismutase expression 3-fold), probably due to a hypoxic event during
      anaesthesia. Later impacts were detected in muscles 21 days after anaesthesia
      (ATP synthase subunit 6 3-fold, NADH deshydrogenase subunit 5 4-fold and
      mitochondrial superoxide dismutase 3-fold increased) revealing oxidative stress
      from an accrued mitochondrial respiratory metabolism. Hormone dosages showed that
      the use of Eugenol reduced the release of plasma cortisol during anaesthesia.
      However, this impact seemed to be reversible within one day. In case of
      electro-narcosis, no significant variation in transcriptional levels could be
      detected between anaesthetized and unanaesthetized eels. Our results suggest that
      the use of Eugenol as an aesthetic in ecotoxicological studies measuring gene
      expression or plasma cortisol concentration is not appropriate, while
      electro-narcosis does not seem to have any impact, at least on the parameters
      taken into consideration in this study.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Renault, S
AU  - Renault S
AD  - University Bordeaux 1, UMR-EPOC CNRS-5805, Aquatic Ecotoxicology team (AE),
      Arcachon, France. so_renault@hotmail.com
FAU - Daverat, F
AU  - Daverat F
FAU - Pierron, F
AU  - Pierron F
FAU - Gonzalez, P
AU  - Gonzalez P
FAU - Dufour, S
AU  - Dufour S
FAU - Lanceleur, L
AU  - Lanceleur L
FAU - Schafer, J
AU  - Schafer J
FAU - Baudrimont, M
AU  - Baudrimont M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110430
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - 0 (Anesthetics)
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Water Pollutants, Chemical)
RN  - 3T8H1794QW (Eugenol)
RN  - EC 1.11.1.6 (Catalase)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Anesthetics/metabolism/*toxicity
MH  - Anguilla/genetics/metabolism/*physiology
MH  - Animals
MH  - Catalase/metabolism
MH  - Electronarcosis/*adverse effects
MH  - Endocrine Disruptors/toxicity
MH  - Endocrine System/drug effects/metabolism
MH  - Eugenol/*toxicity
MH  - Gene Expression/drug effects
MH  - Hydrocortisone/blood
MH  - Water Pollutants, Chemical/*toxicity
EDAT- 2011/05/03 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/05/03 06:00
PHST- 2010/06/16 00:00 [received]
PHST- 2011/02/21 00:00 [revised]
PHST- 2011/04/02 00:00 [accepted]
PHST- 2011/05/03 06:00 [entrez]
PHST- 2011/05/03 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
AID - S0147-6513(11)00093-5 [pii]
AID - 10.1016/j.ecoenv.2011.04.009 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2011 Sep;74(6):1573-7. doi: 10.1016/j.ecoenv.2011.04.009.
      Epub 2011 Apr 30.


PMID- 21530911
OWN - NLM
STAT- MEDLINE
DCOM- 20110719
LR  - 20110502
IS  - 1865-9217 (Print)
IS  - 1865-9217 (Linking)
VI  - 105
IP  - 3
DP  - 2011
TI  - [Data transparency - an ethical imperative? Approaching the issues].
PG  - 207-13
LID - 10.1016/j.zefq.2011.03.009 [doi]
AB  - Several studies show that the findings of clinical trials are often not published
      in full, resulting in a biased presentation of results (publication bias). First,
      this paper discusses the ethical arguments in favour of complete transparency of 
      biomedical research data. There are relevant deontological (like obligations
      towards study participants and research sponsors) and consequentialist (harm for 
      patients and misallocation of scarce resources) ethical reasons for the full
      publication of all trial results, which cannot be overridden by counter arguments
      like freedom of research, data protection or the individual interests of
      researchers and manufacturers. The article therefore discusses (1) which
      strategies are appropriate to guarantee data transparency and (2) who bears
      responsibility for the implementation of these strategies. Finally, open
      questions and the need for further action will be discussed.
CI  - Copyright (c) 2011. Published by Elsevier GmbH.
FAU - Marckmann, Georg
AU  - Marckmann G
AD  - Institut fur Ethik, Geschichte und Theorie der Medizin,
      Ludwig-Maximilians-Universitat Munchen. marckmann@lmu.de
FAU - Strech, Daniel
AU  - Strech D
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Datentransparenz - ein ethischer Imperativ? Eine Problemskizze.
DEP - 20110409
PL  - Netherlands
TA  - Z Evid Fortbild Qual Gesundhwes
JT  - Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen
JID - 101477604
SB  - IM
MH  - Access to Information/*ethics
MH  - Clinical Trials as Topic/*ethics
MH  - Computer Security/ethics
MH  - *Ethics, Research
MH  - Germany
MH  - Humans
MH  - Industry/ethics
MH  - Publishing/*ethics
EDAT- 2011/05/03 06:00
MHDA- 2011/07/20 06:00
CRDT- 2011/05/03 06:00
PHST- 2011/05/03 06:00 [entrez]
PHST- 2011/05/03 06:00 [pubmed]
PHST- 2011/07/20 06:00 [medline]
AID - S1865-9217(11)00075-4 [pii]
AID - 10.1016/j.zefq.2011.03.009 [doi]
PST - ppublish
SO  - Z Evid Fortbild Qual Gesundhwes. 2011;105(3):207-13. doi:
      10.1016/j.zefq.2011.03.009. Epub 2011 Apr 9.


PMID- 21530317
OWN - NLM
STAT- MEDLINE
DCOM- 20111031
LR  - 20131121
IS  - 1557-3117 (Electronic)
IS  - 1053-2498 (Linking)
VI  - 30
IP  - 8
DP  - 2011 Aug
TI  - Inhaled nitric oxide after left ventricular assist device implantation: a
      prospective, randomized, double-blind, multicenter, placebo-controlled trial.
PG  - 870-8
LID - 10.1016/j.healun.2011.03.005 [doi]
AB  - BACKGROUND: Used frequently for right ventricular dysfunction (RVD), the clinical
      benefit of inhaled nitric oxide (iNO) is still unclear. We conducted a
      randomized, double-blind, controlled trial to determine the effect of iNO on
      post-operative outcomes in the setting of left ventricular assist device (LVAD)
      placement. METHODS: Included were 150 patients undergoing LVAD placement with
      pulmonary vascular resistance >/= 200 dyne/sec/cm(-5). Patients received iNO (40 
      ppm) or placebo (an equivalent concentration of nitrogen) until 48 hours after
      separation from cardiopulmonary bypass, extubation, or upon meeting study-defined
      RVD. For ethical reasons, crossover to open-label iNO was allowed during the
      48-hour treatment period if RVD criteria were met. RESULTS: RVD criteria were met
      by 7 of 73 patients (9.6%; 95% confidence interval, 2.8-16.3) in the iNO group
      compared with 12 of 77 (15.6%; 95% confidence interval, 7.5-23.7) who received
      placebo (p = 0.330). Time on mechanical ventilation decreased in the iNO group
      (median days, 2.0 vs 3.0; p = 0.077), and fewer patients in the iNO group
      required an RVAD (5.6% vs 10%; p = 0.468); however, these trends did not meet
      statistical boundaries of significance. Hospital stay, intensive care unit stay, 
      and 28-day mortality rates were similar between groups, as were adverse events.
      Thirty-five patients crossed over to open-label iNO (iNO, n = 15; placebo, n =
      20). Eighteen patients (iNO, n = 9; placebo, n = 9) crossed over before RVD
      criteria were met. CONCLUSIONS: Use of iNO at 40 ppm in the perioperative phase
      of LVAD implantation did not achieve significance for the primary end point of
      reduction in RVD. Similarly, secondary end points of time on mechanical
      ventilation, hospital or intensive care unit stay, and the need for RVAD support 
      after LVAD placement were not significantly improved.
CI  - Copyright (c) 2011 International Society for Heart and Lung Transplantation.
      Published by Elsevier Inc. All rights reserved.
FAU - Potapov, Evgenij
AU  - Potapov E
AD  - Deutsches Herzzentrum Berlin, Berlin, Germany.
FAU - Meyer, Dan
AU  - Meyer D
FAU - Swaminathan, Madhav
AU  - Swaminathan M
FAU - Ramsay, Michael
AU  - Ramsay M
FAU - El Banayosy, Aly
AU  - El Banayosy A
FAU - Diehl, Christoph
AU  - Diehl C
FAU - Veynovich, Bryan
AU  - Veynovich B
FAU - Gregoric, Igor D
AU  - Gregoric ID
FAU - Kukucka, Marian
AU  - Kukucka M
FAU - Gromann, Tom W
AU  - Gromann TW
FAU - Marczin, Nandor
AU  - Marczin N
FAU - Chittuluru, Kanti
AU  - Chittuluru K
FAU - Baldassarre, James S
AU  - Baldassarre JS
FAU - Zucker, Mark J
AU  - Zucker MJ
FAU - Hetzer, Roland
AU  - Hetzer R
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110429
PL  - United States
TA  - J Heart Lung Transplant
JT  - The Journal of heart and lung transplantation : the official publication of the
      International Society for Heart Transplantation
JID - 9102703
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - IM
MH  - Administration, Inhalation
MH  - Aged
MH  - Double-Blind Method
MH  - Endpoint Determination
MH  - Female
MH  - Heart Failure/mortality/*therapy
MH  - *Heart-Assist Devices
MH  - Humans
MH  - Length of Stay
MH  - Male
MH  - Middle Aged
MH  - Nitric Oxide/*administration & dosage/pharmacology/*therapeutic use
MH  - Perioperative Period
MH  - Prospective Studies
MH  - Survival Rate
MH  - Treatment Outcome
MH  - Vascular Resistance/drug effects
MH  - Ventricular Dysfunction, Right/physiopathology/*prevention & control
EDAT- 2011/05/03 06:00
MHDA- 2011/11/01 06:00
CRDT- 2011/05/03 06:00
PHST- 2010/10/09 00:00 [received]
PHST- 2011/02/23 00:00 [revised]
PHST- 2011/03/02 00:00 [accepted]
PHST- 2011/05/03 06:00 [entrez]
PHST- 2011/05/03 06:00 [pubmed]
PHST- 2011/11/01 06:00 [medline]
AID - S1053-2498(11)00867-9 [pii]
AID - 10.1016/j.healun.2011.03.005 [doi]
PST - ppublish
SO  - J Heart Lung Transplant. 2011 Aug;30(8):870-8. doi: 10.1016/j.healun.2011.03.005.
      Epub 2011 Apr 29.


PMID- 21530303
OWN - NLM
STAT- MEDLINE
DCOM- 20111102
LR  - 20181201
IS  - 1036-7314 (Print)
IS  - 1036-7314 (Linking)
VI  - 24
IP  - 2
DP  - 2011 May
TI  - Re: Explicit declaration of ethical approval for clinical research.
PG  - 90
LID - 10.1016/j.aucc.2011.04.002 [doi]
FAU - Leslie, Gavin D
AU  - Leslie GD
LA  - eng
PT  - Letter
PT  - Comment
DEP - 20110506
PL  - Australia
TA  - Aust Crit Care
JT  - Australian critical care : official journal of the Confederation of Australian
      Critical Care Nurses
JID - 9207852
CON - Aust Crit Care. 2011 May;24(2):89. PMID: 21546261
MH  - Biomedical Research/*ethics
MH  - *Helsinki Declaration
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - *Journalism, Medical
MH  - *Periodicals as Topic
EDAT- 2011/05/03 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/05/03 06:00
PHST- 2011/05/03 06:00 [entrez]
PHST- 2011/05/03 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
AID - S1036-7314(11)00053-1 [pii]
AID - 10.1016/j.aucc.2011.04.002 [doi]
PST - ppublish
SO  - Aust Crit Care. 2011 May;24(2):90. doi: 10.1016/j.aucc.2011.04.002. Epub 2011 May
      6.


PMID- 21530007
OWN - NLM
STAT- MEDLINE
DCOM- 20111027
LR  - 20110606
IS  - 1578-1747 (Electronic)
IS  - 0211-139X (Linking)
VI  - 46
IP  - 3
DP  - 2011 May-Jun
TI  - [Informing of the diagnosis in dementia].
PG  - 163-9
LID - 10.1016/j.regg.2011.01.008 [doi]
AB  - Dementia is a syndrome characterized by a progressive deterioration of cognitive 
      functions, accompanied by psychiatric symptoms and behavioral disturbances that
      produce a progressive and irreversible disability. The way it should communicate 
      the diagnosis of dementia is a key discussion point on which there is no
      unanimous agreement so far. The communicating of the diagnosis of dementia is a
      complex issue that affects not only, the patient but also to caregivers and
      health professionals who care and must conform to the ethical principles
      governing medical practice (autonomy, nonmaleficence, beneficence, and justice). 
      Therefore, from the Dementia Working Group of the Catalan Geriatric Society
      (Grupo de Trabajo de Demencia de la Sociedad Catalana de Geriatria) arises the
      need to review the issue and propose a course of action for the disclosure of
      diagnosis.
CI  - Copyright (c) 2010 SEGG. Published by Elsevier Espana. All rights reserved.
FAU - Robles, Maria Jose
AU  - Robles MJ
AD  - Servicio de Geriatria del Parc de Salut Mar, Instituto de Geriatria, Hospital
      Esperanca, Centre Forum, Hospital del Mar, Barcelona, Espana.
      91737@parcdesalutmar.cat
FAU - Cucurella, Eulalia
AU  - Cucurella E
FAU - Formiga, Francesc
AU  - Formiga F
FAU - Fort, Isabel
AU  - Fort I
FAU - Rodriguez, Daniel
AU  - Rodriguez D
FAU - Barranco, Elena
AU  - Barranco E
FAU - Catena, Joan
AU  - Catena J
FAU - Cubi, Dolors
AU  - Cubi D
CN  - Grupo de Trabajo de Demencia de la Sociedad Catalana de Geriatria y Gerontologia
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Practice Guideline
PT  - Review
TT  - La informacion del diagnostico en la demencia.
DEP - 20110429
PL  - Spain
TA  - Rev Esp Geriatr Gerontol
JT  - Revista espanola de geriatria y gerontologia
JID - 8009022
SB  - IM
MH  - Dementia/*diagnosis
MH  - Family
MH  - Humans
MH  - *Truth Disclosure
EDAT- 2011/05/03 06:00
MHDA- 2011/10/28 06:00
CRDT- 2011/05/03 06:00
PHST- 2010/08/02 00:00 [received]
PHST- 2011/01/25 00:00 [revised]
PHST- 2011/01/25 00:00 [accepted]
PHST- 2011/05/03 06:00 [entrez]
PHST- 2011/05/03 06:00 [pubmed]
PHST- 2011/10/28 06:00 [medline]
AID - S0211-139X(11)00082-5 [pii]
AID - 10.1016/j.regg.2011.01.008 [doi]
PST - ppublish
SO  - Rev Esp Geriatr Gerontol. 2011 May-Jun;46(3):163-9. doi:
      10.1016/j.regg.2011.01.008. Epub 2011 Apr 29.


PMID- 21529370
OWN - NLM
STAT- MEDLINE
DCOM- 20110906
LR  - 20211020
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 12
DP  - 2011 Apr 30
TI  - A Depression Recognition and Treatment package for families living with Stroke
      (DepReT-Stroke): study protocol for a randomised controlled trial.
PG  - 105
LID - 10.1186/1745-6215-12-105 [doi]
AB  - BACKGROUND: Depression occurs in up to 50% of patients after stroke and limits
      rehabilitation and recovery. Mood disorders are also highly prevalent in carers; 
      their mental health intertwined with the physical and mental wellbeing of the
      person they are caring for. We argue that working with families, rather than
      patients alone may improve the treatment of depression in both patients and their
      carers enhancing the mental wellbeing and quality of life of both. METHODS: A
      single blind cluster randomised controlled trial to evaluate whether families
      after stroke who are treated with the Depression Recognition and Treatment
      package (DepReT-Stroke) in addition to treatment as usual (TAU) show improved
      mental well being compared to those families who receive only TAU. We aim to
      recruit one hundred and twenty-six families (63 in each group). The DepReT-Stroke
      intervention will help families to consider the various treatment options for
      depression, make choices about which are likely to fit best with their lives and 
      support them in the use of self-help therapies (e.g. computerised Cognitive
      Behavioural Therapy or exercise). An essential component of the DepReT-Stroke
      package will be to help people adhere to their chosen treatment(s). The primary
      outcome will be the Mental Component Subscale of the SF-36 assessed at baseline
      and again six months post intervention. Effectiveness of the intervention will be
      determined using analysis of co-variance; comparing the mean change in MCS scores
      from baseline to six months follow-up adjusting for the clustering effects of
      baseline scores and family. An economic evaluation of the intervention will help 
      us determine whether the intervention represents a cost-effective use of
      resources. DISCUSSION: Depression both for patients and their carers is common
      after stroke. Our Depression Recognition and Treatment package (DepReT-stroke)
      may help clinicians be more effective at detecting and managing a common
      co-morbidity that limits rehabilitation and recovery. TRIAL REGISTRATION: ISRCTN:
      ISRCTN32451749 Research Ethics Committee Reference Number: 10/H0310/23 Grant
      Reference Number: (NIHR) PB-PG-0808-17056.
FAU - Gray, Richard J
AU  - Gray RJ
AD  - Faculty of Medicine and Health Science, University of East Anglia, Norwich, UK.
      richard.gray@uea.ac.uk
FAU - Myint, Phyo K
AU  - Myint PK
FAU - Elender, Frances
AU  - Elender F
FAU - Barton, Garry
AU  - Barton G
FAU - Pfeil, Michael
AU  - Pfeil M
FAU - Price, Gill
AU  - Price G
FAU - Wyatt, Niki
AU  - Wyatt N
FAU - Ravenhill, Garth
AU  - Ravenhill G
FAU - Thomas, Ester
AU  - Thomas E
FAU - Jagger, Jenny
AU  - Jagger J
FAU - Hursey, Amelia
AU  - Hursey A
FAU - Waterfield, Kelly
AU  - Waterfield K
FAU - Hardy, Sheila
AU  - Hardy S
LA  - eng
SI  - ISRCTN/ISRCTN32451749
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110430
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
SB  - IM
MH  - Clinical Protocols
MH  - Depression/*diagnosis/*drug therapy
MH  - Humans
MH  - Single-Blind Method
MH  - Stroke/*psychology
PMC - PMC3096922
EDAT- 2011/05/03 06:00
MHDA- 2011/09/07 06:00
CRDT- 2011/05/03 06:00
PHST- 2011/03/08 00:00 [received]
PHST- 2011/04/30 00:00 [accepted]
PHST- 2011/05/03 06:00 [entrez]
PHST- 2011/05/03 06:00 [pubmed]
PHST- 2011/09/07 06:00 [medline]
AID - 1745-6215-12-105 [pii]
AID - 10.1186/1745-6215-12-105 [doi]
PST - epublish
SO  - Trials. 2011 Apr 30;12:105. doi: 10.1186/1745-6215-12-105.


PMID- 21529358
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1744-8603 (Electronic)
IS  - 1744-8603 (Linking)
VI  - 7
DP  - 2011 Apr 29
TI  - Trust and the regulation of pharmaceuticals: South Asia in a globalised world.
PG  - 10
LID - 10.1186/1744-8603-7-10 [doi]
AB  - BACKGROUND: Building appropriate levels of trust in pharmaceuticals is a
      painstaking and challenging task, involving participants from different spheres
      of life, including producers, distributors, retailers, prescribers, patients and 
      the mass media. Increasingly, however, trust is not just a national matter, but
      involves cross-border flows of knowledge, threats and promises. METHODS: Data for
      this paper comes from the project 'Tracing Pharmaceuticals in South Asia', which 
      used ethnographic fieldwork and qualitative interviews to compared the
      trajectories of three pharmaceuticals (Rifampicin, Oxytocin and Fluoxetine) from 
      producer to patient in three sites (north India, West Bengal and Nepal) between
      2005-08. RESULTS: We argue that issues of trust are crucial in reducing the
      likelihood of appropriate use of medicines. Unlike earlier discussions of trust, 
      we suggest that trust contexts beyond the patient-practitioner relationship are
      important. We illustrate these arguments through three case studies: (i) a
      conflict over ethics in Nepal, involving a suggested revised ethical code for
      retailers, medical representatives, producers and prescribers; (ii) disputes over
      counterfeit, fake, substandard and spurious medicines, and quality standards in
      Indian generic companies, looking particularly at the role played by the US FDA; 
      and (iii) the implications of lack of trust in the DOTS programmes in India and
      Nepal for the relationships among patients, government and the private sector.
      CONCLUSIONS: We conclude that the building of trust is a necessary but always
      vulnerable and contingent process. While it might be desirable to outline steps
      that can be taken to build trust, the range of conflicting interests in the
      pharmaceutical field make feasible solutions hard to implement.
FAU - Brhlikova, Petra
AU  - Brhlikova P
AD  - School of Social and Political Science, University of Edinburgh, Edinburgh, UK.
      rjeffery@staffmail.ed.ac.uk.
FAU - Harper, Ian
AU  - Harper I
FAU - Jeffery, Roger
AU  - Jeffery R
FAU - Rawal, Nabin
AU  - Rawal N
FAU - Subedi, Madhusudhan
AU  - Subedi M
FAU - Santhosh, Mr
AU  - Santhosh M
LA  - eng
PT  - Journal Article
DEP - 20110429
PL  - England
TA  - Global Health
JT  - Globalization and health
JID - 101245734
PMC - PMC3104379
EDAT- 2011/05/03 06:00
MHDA- 2011/05/03 06:01
CRDT- 2011/05/03 06:00
PHST- 2010/10/26 00:00 [received]
PHST- 2011/04/29 00:00 [accepted]
PHST- 2011/05/03 06:00 [entrez]
PHST- 2011/05/03 06:00 [pubmed]
PHST- 2011/05/03 06:01 [medline]
AID - 1744-8603-7-10 [pii]
AID - 10.1186/1744-8603-7-10 [doi]
PST - epublish
SO  - Global Health. 2011 Apr 29;7:10. doi: 10.1186/1744-8603-7-10.


PMID- 21528800
OWN - NLM
STAT- MEDLINE
DCOM- 20110531
LR  - 20170203
IS  - 0723-1393 (Print)
IS  - 0723-1393 (Linking)
VI  - 30
IP  - 1
DP  - 2011 Mar
TI  - Informed consent under the European Convention on Biomedicine and the UNESCO
      Declaration on Bioethics.
PG  - 101-13
AB  - The desirability of obtaining freely given consent is universally accepted. The
      point, however, is that there is no unanimity on the definition of informed
      consent or its application in bioethics. Whether informed consent is based on
      principalism or casuistry or the virtue theory, the problem is how to handle the 
      ethically complex situation created in the interface between informed consent and
      social justice under international biomedical instruments. This article will
      proceed by offering detailed historical and critical analyses of informed consent
      under the European Convention on Human Rights and Biomedicine 1997 and The UNESCO
      Universal Declaration on Bioethics and Human Rights 2005. Three conceptions of
      justice will be utilised to show that the doctrine of informed consent has driven
      the ethos of research on human beings and shaped the physician-patient
      relationship; and that casuistry and virtue theory are consistent with and not
      rivals of a principle-based account of informed consent.
FAU - Salako, Solomon E
AU  - Salako SE
AD  - Liverpool John Moores University, John Foster Building, 98 Mount Pleasant,
      Liverpool L3 5UZ, United Kingdom. s.e.salako@ljmu.ac.uk
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Law
JT  - Medicine and law
JID - 8218185
SB  - IM
MH  - *Bioethical Issues
MH  - Human Rights/legislation & jurisprudence
MH  - Humans
MH  - *Informed Consent
MH  - United Nations
EDAT- 2011/05/03 06:00
MHDA- 2011/06/01 06:00
CRDT- 2011/05/03 06:00
PHST- 2011/05/03 06:00 [entrez]
PHST- 2011/05/03 06:00 [pubmed]
PHST- 2011/06/01 06:00 [medline]
PST - ppublish
SO  - Med Law. 2011 Mar;30(1):101-13.


PMID- 21528799
OWN - NLM
STAT- MEDLINE
DCOM- 20110531
LR  - 20170203
IS  - 0723-1393 (Print)
IS  - 0723-1393 (Linking)
VI  - 30
IP  - 1
DP  - 2011 Mar
TI  - Bioethics education on deliberation--a view of a novel: Blue Gold, by Clive
      Cussler.
PG  - 79-99
AB  - Since the focus of Bioethics is the bridge between Humanities and the Life
      Sciences and bearing in mind that this bridge is often difficult to build, those 
      who believe that this dialogue is important in our days should promote it through
      Education. By educating in Bioethics it is possible to improve the participation 
      of the citizens in debates on the ethical issues raised by new technologies and
      scientific research. It is our conviction that literary texts are laboratories of
      ethical judgment, where the ethical questions concerning specific scientific/
      technological issues are addressed in an imaginary world. Therefore our purpose
      is to present a framework for ethical deliberation through the use of literature.
      Fiction allows us to "practise" ethical decision making, by focusing on the
      particular cases of the characters of the story and by checking how the
      principles/theories working in the background apply to the narrated cases.
FAU - Magalhaes, Susana
AU  - Magalhaes S
AD  - Research Centre of Bioethics, Institute of Bioethics, Portuguese Catholic
      University. Rua Diogo Botelho P-4150-005 Porto, Portugal. susanavtm@gmail.com
FAU - Araujo, Joana
AU  - Araujo J
FAU - Carvalho, Ana Sofia
AU  - Carvalho AS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Law
JT  - Medicine and law
JID - 8218185
SB  - IM
MH  - Bioethics/*education
MH  - *Ethical Analysis
MH  - Humans
MH  - Literature
MH  - Social Responsibility
MH  - Water Supply
EDAT- 2011/05/03 06:00
MHDA- 2011/06/01 06:00
CRDT- 2011/05/03 06:00
PHST- 2011/05/03 06:00 [entrez]
PHST- 2011/05/03 06:00 [pubmed]
PHST- 2011/06/01 06:00 [medline]
PST - ppublish
SO  - Med Law. 2011 Mar;30(1):79-99.


PMID- 21528798
OWN - NLM
STAT- MEDLINE
DCOM- 20110531
LR  - 20170203
IS  - 0723-1393 (Print)
IS  - 0723-1393 (Linking)
VI  - 30
IP  - 1
DP  - 2011 Mar
TI  - Ethics at Israeli universities: unlearned lessons from professional ethics.
PG  - 65-78
AB  - At the practical level, sustained attention to ethical issues in academia in
      Israel is inadequate. This paper suggests that professional models of ethics
      education and training present constructive alternatives. The author views this
      topic from the dual perspective of a professional clinical psychologist and a
      committed faculty member. After a brief introduction, the paper opens with a case
      vignette of ethical violations of trust in academia, its handling, and how a
      similar case 25 years later illustrates the lack of progress in preparing the
      academic community for such things. A discussion of normative actions and
      behavioral norms in academia follows. Three lessons from the professions are
      offered: 1) the importance of involving members in the process of identifying
      ethical violations; 2) the value of adopting for academia current practices
      preparing persons for work in research, (for example the standardization of
      online modules for training in ethics); and c) the significance of addressing
      self-interest and its limits. If silence around a code of ethics is being
      practiced, that silence should be broken.
FAU - Rubin, Simon Shimshon
AU  - Rubin SS
AD  - International Center for the Study of Loss, Breavement and Human Resilience,
      Department of Psychology, University of Haifa, Haifa 31950, Israel.
      rubin@psy.haifa.ac.il
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Law
JT  - Medicine and law
JID - 8218185
SB  - IM
MH  - Ethics, Professional/*education
MH  - Humans
MH  - Israel
MH  - Universities
EDAT- 2011/05/03 06:00
MHDA- 2011/06/01 06:00
CRDT- 2011/05/03 06:00
PHST- 2011/05/03 06:00 [entrez]
PHST- 2011/05/03 06:00 [pubmed]
PHST- 2011/06/01 06:00 [medline]
PST - ppublish
SO  - Med Law. 2011 Mar;30(1):65-78.


PMID- 21528795
OWN - NLM
STAT- MEDLINE
DCOM- 20110531
LR  - 20170203
IS  - 0723-1393 (Print)
IS  - 0723-1393 (Linking)
VI  - 30
IP  - 1
DP  - 2011 Mar
TI  - Surrogate motherhood as a medical treatment procedure for women's infertility.
PG  - 23-37
AB  - The content of this work is conceived on the research of the consequences of
      surrogate motherhood as a process of assisted procreation, which represent a way 
      of parenthood in cases when it is not possible to realize parenthood through a
      natural way. Surrogate motherhood is a process in which a woman (surrogate
      mother) agrees to carry a pregnancy with the intent to give the child to the
      couple with whom she has made a contract on surrogate maternity after the birth. 
      This process of conception and birth makes the determination of the child's
      origin on its mother's side hard to determine, because of the distinction of the 
      genetic and gestation phases of the two women. The concept of surrogate
      motherhood is to appear in two forms, depending on the existence or the
      non-existence of the genetic link between the surrogate mother and the child she 
      gives birth to. There are gestation (full) and genetic (partial) surrogates each 
      with different modalities and legal and ethical implications. In Serbia,
      Infertility Treatment and the Bio-medically Assisted Procreation Act from 2009
      explicitly forbids surrogate motherhood, despite the fact that an infertile
      couple decides to use it, as a rule, after having tried all other treatment
      procedures, in cases when there is a diagnosis but the conventional treatment
      applied has not produced the desired results. Given the fact that no one has the 
      right to ignore the sufferings of people who cannot procreate naturally, the
      medical practice and legal science in our country plead for a formulation of a
      legal framework in which to apply surrogate motherhood as an infertility
      treatment, under particular conditions.
FAU - Jovic, Olga S
AU  - Jovic OS
AD  - Law Faculty, University of Pristina, Headed in Kosovska Mitrovica Belgrade,
      Serbia. jovicolga@sbb.rs
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Law
JT  - Medicine and law
JID - 8218185
SB  - IM
MH  - Female
MH  - Humans
MH  - Infertility, Female/*therapy
MH  - Pregnancy
MH  - Reproductive Rights/legislation & jurisprudence
MH  - Serbia
MH  - Surrogate Mothers/*legislation & jurisprudence
EDAT- 2011/05/03 06:00
MHDA- 2011/06/01 06:00
CRDT- 2011/05/03 06:00
PHST- 2011/05/03 06:00 [entrez]
PHST- 2011/05/03 06:00 [pubmed]
PHST- 2011/06/01 06:00 [medline]
PST - ppublish
SO  - Med Law. 2011 Mar;30(1):23-37.


PMID- 21528736
OWN - NLM
STAT- MEDLINE
DCOM- 20110531
LR  - 20181201
IS  - 1320-159X (Print)
IS  - 1320-159X (Linking)
VI  - 18
IP  - 3
DP  - 2011 Mar
TI  - What makes a real man? Gender norms and Western Australia v. AH [2010] WASCA 172.
PG  - 478-97
AB  - In Western Australia v AH [2010] WASCA 172 the Western Australian Court of Appeal
      denied two female-to-male applicants for gender reassignment certificates the
      right to be legally recognised as men. In so doing, an opportunity was lost for
      Australia to be one of the first jurisdictions in the world to legally provide a 
      reassignment of gender without requiring permanent sterilising surgery. This
      column examines not only the legal issues considered in the case but the broader 
      ethical and human rights issues associated with denying female-to-male gender
      reassignment applicants who have not undergone a permanent sterilisation or
      genitalia alteration procedure, the right to be identified as males.
FAU - Townsend, Ruth
AU  - Townsend R
AD  - College of Law and Medical School, The Australian National University.
FAU - Klar, Danielle
AU  - Klar D
FAU - Faunce, Thomas
AU  - Faunce T
LA  - eng
PT  - Journal Article
PT  - Legal Case
PL  - Australia
TA  - J Law Med
JT  - Journal of law and medicine
JID - 9431853
SB  - IM
MH  - Australia
MH  - Female
MH  - Human Rights/legislation & jurisprudence
MH  - Humans
MH  - Male
MH  - *Sex Reassignment Procedures
EDAT- 2011/05/03 06:00
MHDA- 2011/06/01 06:00
CRDT- 2011/05/03 06:00
PHST- 2011/05/03 06:00 [entrez]
PHST- 2011/05/03 06:00 [pubmed]
PHST- 2011/06/01 06:00 [medline]
PST - ppublish
SO  - J Law Med. 2011 Mar;18(3):478-97.


PMID- 30082944
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 0024-3639 (Print)
IS  - 0024-3639 (Linking)
VI  - 78
IP  - 2
DP  - 2011 May
TI  - Safe Passages: Pro-Life Response to the Tragedy of Maternal Deaths.
PG  - 202-210
LID - 10.1179/002436311803888393 [doi]
AB  - Maternal mortality in Africa remains unacceptably high. The prevailing response
      to reducing maternal mortality has emphasized "reproductive health" and has
      failed to clearly focus on those causes responsible for 90 percent of maternal
      deaths. In contrast, the "Safe Passages" model directs training and resources
      toward interventions that save the lives of mothers and babies. Within the Safe
      Passages model, a "premise" and an "equation" offer an ethical and strategic
      framework for maternal health-care development which respects human life and
      dignity and prioritizes those interventions most likely to reduce maternal and
      newborn deaths. The Safe Passages "equation" emphasizes the key components of
      respect for persons, safe birth, and fertility literacy. Successful training and 
      development programs should work to insure participants and organizations are
      inspired, educated, equipped, and evaluated.
FAU - Mulcaire-Jones, George
AU  - Mulcaire-Jones G
AD  - Maternal Life International (MLI), starting its twelfth year as a global,
      non-profit AIDS avoidance and family health services organization based in Butte,
      Montana.
FAU - Scanlon, Robert
AU  - Scanlon R
AD  - Medical programs, Aiding Infants and Mothers (AIM), an organization based on Long
      Island, New York, Africa and helps provide medicines.
LA  - eng
PT  - Journal Article
DEP - 20110501
PL  - United States
TA  - Linacre Q
JT  - The Linacre quarterly
JID - 2985221R
PMC - PMC6027016
EDAT- 2011/05/01 00:00
MHDA- 2011/05/01 00:01
CRDT- 2018/08/08 06:00
PHST- 2018/08/08 06:00 [entrez]
PHST- 2011/05/01 00:00 [pubmed]
PHST- 2011/05/01 00:01 [medline]
AID - 10.1179/002436311803888393 [doi]
AID - 10.1179_002436311803888393 [pii]
PST - ppublish
SO  - Linacre Q. 2011 May;78(2):202-210. doi: 10.1179/002436311803888393. Epub 2011 May
      1.


PMID- 30082943
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 0024-3639 (Print)
IS  - 0024-3639 (Linking)
VI  - 78
IP  - 2
DP  - 2011 May
TI  - Culture, Tradition, and Faith in Global Women's Health: A Caribbean Perspective.
PG  - 195-201
LID - 10.1179/002436311803888339 [doi]
AB  - The legalization of elective induced abortion which swept through many developed 
      Western nations continues as a social and political issue in the Caribbean. Since
      2005, Jamaica has been the focus of an attempt to legalize abortion, and the
      strategies employed bear broad similarities to those which have operated in other
      jurisdictions, including somewhat clandestine attempts to establish a
      "rights-based" approach to women's reproductive health. This intervention by
      non-Jamaican organizations includes two invalid assumptions: 1) A falsely
      inflated rate of abortions, which are illegal in Jamaica and therefore labeled
      "unsafe"; and 2) the role of abortion in Jamaica as a "major cause" of maternal
      mortality. Investigation by the Statistical Institute and National Family
      Planning Board invalidates both assumptions. The origin of the "rights based"
      approach of "full access," initiated and sustained by international NGOs, was
      mediated via an "abortion consultant" closely linked to the Johannesburg
      Initiative, a blueprint for implementation of unrestricted abortion, and the
      APRAG recommendations aimed at providing de facto unrestricted abortion
      throughout pregnancy. This interference in national sovereignty on the part of
      international NGOs occurs despite surveys illustrating that the vast majority of 
      Jamaicans (64%) specifically reject the notion of a "right" to abortion based on 
      evidence rooted in biology, natural law and justice, women's health, sociology,
      and economics. The Jamaican legal protection of the unborn as an ethical and
      cultural norm necessitates its contextualization in a triad which equally
      emphasizes the stability of the family and support for women.
FAU - Brady-West, Doreen
AU  - Brady-West D
AD  - Coalition for the Defense of Life in Jamaica.
LA  - eng
PT  - Journal Article
DEP - 20110501
PL  - United States
TA  - Linacre Q
JT  - The Linacre quarterly
JID - 2985221R
PMC - PMC6027024
EDAT- 2011/05/01 00:00
MHDA- 2011/05/01 00:01
CRDT- 2018/08/08 06:00
PHST- 2018/08/08 06:00 [entrez]
PHST- 2011/05/01 00:00 [pubmed]
PHST- 2011/05/01 00:01 [medline]
AID - 10.1179/002436311803888339 [doi]
AID - 10.1179_002436311803888339 [pii]
PST - ppublish
SO  - Linacre Q. 2011 May;78(2):195-201. doi: 10.1179/002436311803888339. Epub 2011 May
      1.


PMID- 26421020
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150930
LR  - 20200930
IS  - 1738-6349 (Print)
IS  - 1738-6349 (Linking)
VI  - 15
IP  - 2
DP  - 2011 May
TI  - Ideal Experimental Rat Models for Liver Diseases.
PG  - 67-77
LID - 10.14701/kjhbps.2011.15.2.67 [doi]
AB  - There are many limitations for conducting liver disease research in human beings 
      due to the high cost and potential ethical issues. For this reason, conducting a 
      study that is difficult to perform in humans using appropriate animal models, can
      be beneficial in ascertaining the pathological physiology, and in developing new 
      treatment modalities. However, it is difficult to determine the appropriate
      animal model which is suitable for research purposes, since every patient has
      different and diverse clinical symptoms, adverse reactions, and complications due
      to the pathological physiology. Also, it is not easy to reproduce identically
      various clinical situations in animal models. Recently, the Guide for the Care
      and Use of Laboratory Animals has tightened up the regulations, and therefore it 
      is advisable to select the appropriate animals and decide upon the appropriate
      quantities through scientific and systemic considerations before conducting
      animal testing. Therefore, in this review article the authors examined various
      white rat animal testing models and determined the appropriate usable rat model, 
      and the pros and cons of its application in liver disease research. The authors
      believe that this review will be beneficial in selecting proper laboratory
      animals for research purposes.
FAU - Lee, Sang Woo
AU  - Lee SW
AD  - Department of Surgery, Yonsei University College of Medicine, Korea. ; Graduate
      School of Yonsei University, Graduate Program of Nano Science and Technology,
      Korea.
FAU - Kim, Sung Hoon
AU  - Kim SH
AD  - Department of Surgery, Yonsei University College of Medicine, Korea. ; Cell
      Therapy Center, Severance Hospital, Korea.
FAU - Min, Seon Ok
AU  - Min SO
AD  - Department of Surgery, Yonsei University College of Medicine, Korea. ; Graduate
      School of Yonsei University, Graduate Program of Nano Science and Technology,
      Korea.
FAU - Kim, Kyung Sik
AU  - Kim KS
AD  - Department of Surgery, Yonsei University College of Medicine, Korea. ; Cell
      Therapy Center, Severance Hospital, Korea.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110531
PL  - Korea (South)
TA  - Korean J Hepatobiliary Pancreat Surg
JT  - Korean journal of hepato-biliary-pancreatic surgery
JID - 101479046
PMC - PMC4582547
OTO - NOTNLM
OT  - Animal model
OT  - Liver disease
OT  - Rat
EDAT- 2011/05/01 00:00
MHDA- 2011/05/01 00:01
CRDT- 2015/10/01 06:00
PHST- 2015/10/01 06:00 [entrez]
PHST- 2011/05/01 00:00 [pubmed]
PHST- 2011/05/01 00:01 [medline]
AID - 10.14701/kjhbps.2011.15.2.67 [doi]
PST - ppublish
SO  - Korean J Hepatobiliary Pancreat Surg. 2011 May;15(2):67-77. doi:
      10.14701/kjhbps.2011.15.2.67. Epub 2011 May 31.


PMID- 24736717
OWN - NLM
STAT- MEDLINE
DCOM- 20151117
LR  - 20140416
IS  - 1539-0683 (Electronic)
IS  - 0361-929X (Linking)
VI  - 36
IP  - 3
DP  - 2011 May-Jun
TI  - A compelling human rights ethical issue: female genital mutilation.
PG  - 203
LID - 10.1097/NMC.0b013e31820fb50e [doi]
FAU - Callister, Lynn Clark
AU  - Callister LC
AD  - Lynn Clark Callister is a Professor Emerita, College of Nursing, Brigham Young
      University, Provo, UT, and an Editorial Board Member of MCN. She can be reached
      via e-mail at lynn_callister@byu.edu.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - MCN Am J Matern Child Nurs
JT  - MCN. The American journal of maternal child nursing
JID - 7605941
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Circumcision, Female/*ethics
MH  - Emigrants and Immigrants
MH  - Female
MH  - Global Health
MH  - Human Rights Abuses/*ethics/*prevention & control
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
EDAT- 2011/05/01 00:00
MHDA- 2015/11/18 06:00
CRDT- 2014/04/17 06:00
PHST- 2014/04/17 06:00 [entrez]
PHST- 2011/05/01 00:00 [pubmed]
PHST- 2015/11/18 06:00 [medline]
AID - 10.1097/NMC.0b013e31820fb50e [doi]
AID - 00005721-201105000-00017 [pii]
PST - ppublish
SO  - MCN Am J Matern Child Nurs. 2011 May-Jun;36(3):203. doi:
      10.1097/NMC.0b013e31820fb50e.


PMID- 24736716
OWN - NLM
STAT- MEDLINE
DCOM- 20151117
LR  - 20140416
IS  - 1539-0683 (Electronic)
IS  - 0361-929X (Linking)
VI  - 36
IP  - 3
DP  - 2011 May-Jun
TI  - Ethical perspectives of the personal health record.
PG  - 201
LID - 10.1097/NMC.0b013e31820fcec0 [doi]
FAU - McCartney, Patricia R
AU  - McCartney PR
AD  - Patricia R. McCartney is a Senior Clinical Nursing Instructor, Washington
      Hospital Center Georgetown Scholars Program, Washington, DC, Professor Emerita,
      State University of New York at Buffalo, and an Editorial Board Member of MCN.
      She can be reached via e-mail at patricia.mccartney@gmail.com.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - MCN Am J Matern Child Nurs
JT  - MCN. The American journal of maternal child nursing
JID - 7605941
SB  - IM
MH  - Confidentiality/*ethics
MH  - Disclosure/*ethics
MH  - Health Records, Personal/*ethics
MH  - Humans
MH  - *Nurse's Role
EDAT- 2011/05/01 00:00
MHDA- 2015/11/18 06:00
CRDT- 2014/04/17 06:00
PHST- 2014/04/17 06:00 [entrez]
PHST- 2011/05/01 00:00 [pubmed]
PHST- 2015/11/18 06:00 [medline]
AID - 10.1097/NMC.0b013e31820fcec0 [doi]
AID - 00005721-201105000-00016 [pii]
PST - ppublish
SO  - MCN Am J Matern Child Nurs. 2011 May-Jun;36(3):201. doi:
      10.1097/NMC.0b013e31820fcec0.


PMID- 24736715
OWN - NLM
STAT- MEDLINE
DCOM- 20151117
LR  - 20140416
IS  - 1539-0683 (Electronic)
IS  - 0361-929X (Linking)
VI  - 36
IP  - 3
DP  - 2011 May-Jun
TI  - Medically provided hydration and nutrition in infants: ethical considerations.
PG  - 199
LID - 10.1097/NMC.0b013e31820fb0e0 [doi]
FAU - Morin, Karen H
AU  - Morin KH
AD  - Karen H. Morin is a Professor and Director of the PhD program, University of
      Wisconsin-Milwaukee, and an Editorial Board Member of MCN. She can be reached via
      e-mail at KHMorin@sbcglobal.net.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - MCN Am J Matern Child Nurs
JT  - MCN. The American journal of maternal child nursing
JID - 7605941
SB  - IM
MH  - Adult
MH  - Decision Making/*ethics
MH  - Female
MH  - Fluid Therapy/*ethics
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Middle Aged
MH  - Neonatal Nursing/*ethics
MH  - *Nurse's Role
MH  - Nutritional Support/*ethics
MH  - Terminal Care/*ethics
EDAT- 2011/05/01 00:00
MHDA- 2015/11/18 06:00
CRDT- 2014/04/17 06:00
PHST- 2014/04/17 06:00 [entrez]
PHST- 2011/05/01 00:00 [pubmed]
PHST- 2015/11/18 06:00 [medline]
AID - 10.1097/NMC.0b013e31820fb0e0 [doi]
AID - 00005721-201105000-00015 [pii]
PST - ppublish
SO  - MCN Am J Matern Child Nurs. 2011 May-Jun;36(3):199. doi:
      10.1097/NMC.0b013e31820fb0e0.


PMID- 24736708
OWN - NLM
STAT- MEDLINE
DCOM- 20151117
LR  - 20140416
IS  - 1539-0683 (Electronic)
IS  - 0361-929X (Linking)
VI  - 36
IP  - 3
DP  - 2011 May-Jun
TI  - Enhancing maternal child nursing practice through ethical insight.
PG  - 150
LID - 10.1097/NMC.0b013e31820fb29f [doi]
FAU - Callister, Lynn Clark
AU  - Callister LC
AD  - Lynn Clark Callister is a Professor, College of Nursing, Brigham Young
      University, Provo, UT, and an Editorial Board Member of MCN. She can be reached
      via e-mail at lynn_callister@byu.edu. Tanya Sudia-Robinson is a Professor at the 
      Georgia Baptist College of Nursing of Mercer University, Atlanta GA. She can be
      reached by email at tsudiar@hotmail.com.
FAU - Sudia-Robinson, Tanya
AU  - Sudia-Robinson T
LA  - eng
PT  - Editorial
PT  - Introductory Journal Article
PL  - United States
TA  - MCN Am J Matern Child Nurs
JT  - MCN. The American journal of maternal child nursing
JID - 7605941
SB  - IM
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - *Ethics, Nursing
MH  - Family Nursing/*ethics
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Maternal-Child Nursing/*ethics
MH  - Middle Aged
MH  - Neonatal Nursing/*ethics
EDAT- 2011/05/01 00:00
MHDA- 2015/11/18 06:00
CRDT- 2014/04/17 06:00
PHST- 2014/04/17 06:00 [entrez]
PHST- 2011/05/01 00:00 [pubmed]
PHST- 2015/11/18 06:00 [medline]
AID - 10.1097/NMC.0b013e31820fb29f [doi]
AID - 00005721-201105000-00001 [pii]
PST - ppublish
SO  - MCN Am J Matern Child Nurs. 2011 May-Jun;36(3):150. doi:
      10.1097/NMC.0b013e31820fb29f.


PMID- 23905212
OWN - NLM
STAT- MEDLINE
DCOM- 20131112
LR  - 20191027
IS  - 1756-5391 (Electronic)
IS  - 1756-5391 (Linking)
VI  - 4
IP  - 2
DP  - 2011 May
TI  - Medical Research Ethics and Editing Ethics meeting minutes--the 2nd working
      meeting of ChiCTRPC.
PG  - 151-3
LA  - eng
PT  - Congress
PT  - News
PL  - England
TA  - J Evid Based Med
JT  - Journal of evidence-based medicine
JID - 101497477
SB  - IM
MH  - Biomedical Research/*ethics
MH  - *Editorial Policies
MH  - Humans
MH  - Publishing/*ethics
EDAT- 2011/05/01 00:00
MHDA- 2013/11/13 06:00
CRDT- 2013/08/03 06:00
PHST- 2013/08/03 06:00 [entrez]
PHST- 2011/05/01 00:00 [pubmed]
PHST- 2013/11/13 06:00 [medline]
AID - 10.1111/j.1756-5391.2011.01136.x [doi]
PST - ppublish
SO  - J Evid Based Med. 2011 May;4(2):151-3. doi: 10.1111/j.1756-5391.2011.01136.x.


PMID- 23722379
OWN - NLM
STAT- MEDLINE
DCOM- 20130828
LR  - 20191210
IS  - 1538-7488 (Electronic)
IS  - 0002-936X (Linking)
VI  - 111
IP  - 5
DP  - 2011 May
TI  - Organ donation after circulatory death: vital partnerships.
PG  - 32-8; quiz 39-40
LID - 10.1097/01.NAJ.0000398047.85051.ab [doi]
AB  - OVERVIEW: The authors present the case of a woman in her mid-50s who sustained
      extensive brain injury in an accident but wasn't declared brain dead. The case
      highlights some of the clinical and ethical considerations of organ donation
      after circulatory death (also known as non-heart-beating donation and donation
      after cardiac death). It also illustrates the interdisciplinary teamwork
      necessary for organ donation in such cases, involving nurses and other clinicians
      in the ICU, palliative care, and the local organ procurement organization, among 
      others. KEYWORDS: cardiac death, circulatory death, donation after cardiac death,
      end-of-life care, ethics, non-heart-beating donation, organ donation, organ
      donation after circulatory death, organ transplantation, palliative care.
FAU - Ringos Beach, Patricia
AU  - Ringos Beach P
AD  - Mercy Cancer Center, Toledo, OH, USA. pbeach@bex.net
FAU - Hallett, Annette M
AU  - Hallett AM
FAU - Zaruca, Kim
AU  - Zaruca K
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Am J Nurs
JT  - The American journal of nursing
JID - 0372646
SB  - IM
MH  - *Brain Injuries
MH  - Centers for Medicare and Medicaid Services, U.S./standards
MH  - *Death
MH  - Female
MH  - Glasgow Coma Scale/standards
MH  - Humans
MH  - Life Support Care/ethics/standards
MH  - Living Wills
MH  - Middle Aged
MH  - Organ Transplantation/*ethics/standards/statistics & numerical data
MH  - Organizational Policy
MH  - Palliative Care/ethics/standards
MH  - Patient Care Team/*ethics/organization & administration
MH  - Patient Preference
MH  - Professional-Family Relations
MH  - Time Factors
MH  - Tissue and Organ Procurement/*ethics/standards/statistics & numerical data
MH  - United States/epidemiology
MH  - Withholding Treatment/ethics/standards
EDAT- 2011/05/01 00:00
MHDA- 2013/08/29 06:00
CRDT- 2013/06/01 06:00
PHST- 2013/06/01 06:00 [entrez]
PHST- 2011/05/01 00:00 [pubmed]
PHST- 2013/08/29 06:00 [medline]
AID - 10.1097/01.NAJ.0000398047.85051.ab [doi]
AID - 00000446-201105000-00021 [pii]
PST - ppublish
SO  - Am J Nurs. 2011 May;111(5):32-8; quiz 39-40. doi:
      10.1097/01.NAJ.0000398047.85051.ab.


PMID- 23672703
OWN - NLM
STAT- MEDLINE
DCOM- 20131112
LR  - 20191210
IS  - 1756-5391 (Electronic)
IS  - 1756-5391 (Linking)
VI  - 4
IP  - 2
DP  - 2011 May
TI  - Ethical issues in preparing and publishing systematic reviews.
PG  - 130-4
LID - 10.1111/j.1756-5391.2011.01122.x [doi]
FAU - Wager, Elizabeth
AU  - Wager E
AD  - Publications Consultant, Sideview, Princes Risborough, UK.
      liz@sideview.demon.co.uk
FAU - Wiffen, Philip J
AU  - Wiffen PJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Evid Based Med
JT  - Journal of evidence-based medicine
JID - 101497477
SB  - IM
MH  - Duplicate Publications as Topic
MH  - Plagiarism
MH  - Publishing/*ethics
MH  - *Review Literature as Topic
MH  - *Writing
EDAT- 2011/05/01 00:00
MHDA- 2013/11/13 06:00
CRDT- 2013/05/16 06:00
PHST- 2013/05/16 06:00 [entrez]
PHST- 2011/05/01 00:00 [pubmed]
PHST- 2013/11/13 06:00 [medline]
AID - 10.1111/j.1756-5391.2011.01122.x [doi]
PST - ppublish
SO  - J Evid Based Med. 2011 May;4(2):130-4. doi: 10.1111/j.1756-5391.2011.01122.x.


PMID- 23193858
OWN - NLM
STAT- MEDLINE
DCOM- 20130108
LR  - 20121130
IS  - 1029-4864 (Print)
IS  - 1029-4864 (Linking)
VI  - 66
IP  - 4
DP  - 2011 May
TI  - Dental ethics case 11. Taking over a practice--what are your ethical obligations 
      in handling the previous practitioner's failed treatment?
PG  - 190
FAU - Naidoo, S
AU  - Naidoo S
AD  - Department of Community Oral Health, University of the Western Cape, Private Bag 
      X1, Tygerberg, 7505. suenaidoo@uwc.ac.za
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - SADJ
JT  - SADJ : journal of the South African Dental Association = tydskrif van die
      Suid-Afrikaanse Tandheelkundige Vereniging
JID - 9812497
MH  - Dental Care/*ethics
MH  - Dentist-Patient Relations/ethics
MH  - Dentists/*ethics
MH  - *Ethics, Dental
MH  - Humans
MH  - Patient Rights/ethics
MH  - Practice Management, Dental/ethics
MH  - Practice Valuation and Purchase/ethics
MH  - Treatment Failure
EDAT- 2011/05/01 00:00
MHDA- 2013/01/09 06:00
CRDT- 2012/12/01 06:00
PHST- 2012/12/01 06:00 [entrez]
PHST- 2011/05/01 00:00 [pubmed]
PHST- 2013/01/09 06:00 [medline]
PST - ppublish
SO  - SADJ. 2011 May;66(4):190.


PMID- 21528428
OWN - NLM
STAT- MEDLINE
DCOM- 20131122
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 18
IP  - 4
DP  - 2012 Dec
TI  - An analysis on the research ethics cases managed by the Committee on Publication 
      Ethics (COPE) between 1997 and 2010.
PG  - 621-31
LID - 10.1007/s11948-011-9273-3 [doi]
AB  - The growing emphasis on the importance of publishing scientific findings in the
      academic world has led to increasing prevalence of potentially significant
      publications in which scientific and ethical rigour may be questioned. This has
      not only hindered research progress, but also eroded public trust in all
      scientific advances. In view of the increasing concern and the complexity of
      research misconduct, the Committee on Publication Ethics (COPE) was established
      in 1997 to manage cases with ethical implications. In order to review the
      outcomes of cases investigated by COPE, a total of 408 cases that had been
      managed by COPE were successfully extracted and analysed with respect to 7
      distinct criteria. The results obtained indicate that the number of ethical
      implications per case has not changed significantly (p > 0.01) since the year
      COPE was instigated. Interestingly, the number of ethical cases, and to some
      extent, research misconduct, is not diminishing. Therefore, journal editors and
      publishers need to work closely together with COPE to inculcate adoption of
      appropriate research ethics and values in younger researchers while discouraging 
      others from lowering standards. It is hoped that with a more concerted effort
      from the academic community and better public awareness, there will be fewer
      incidences of ethically and scientifically challenged publications. The ultimate 
      aim being to enhance the quality of published works with concomittant public
      trust in the results.
FAU - Foo, Jong Yong Abdiel
AU  - Foo JY
AD  - Electronic and Computer Engineering Division, School of Engineering, Ngee Ann
      Polytechnic, 535 Clementi Road, Singapore, 599489, Singapore.
      abdielfoo@hotmail.com
FAU - Wilson, Stephen James
AU  - Wilson SJ
LA  - eng
PT  - Journal Article
DEP - 20110429
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Ethics Committees, Research
MH  - *Ethics, Research
MH  - Humans
MH  - Publications/*ethics/standards
MH  - Publishing/*ethics/standards
MH  - *Scientific Misconduct
EDAT- 2011/04/30 06:00
MHDA- 2013/12/16 06:00
CRDT- 2011/04/30 06:00
PHST- 2010/09/15 00:00 [received]
PHST- 2011/04/13 00:00 [accepted]
PHST- 2011/04/30 06:00 [entrez]
PHST- 2011/04/30 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1007/s11948-011-9273-3 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2012 Dec;18(4):621-31. doi: 10.1007/s11948-011-9273-3. Epub 2011 
      Apr 29.


PMID- 21528402
OWN - NLM
STAT- MEDLINE
DCOM- 20111031
LR  - 20220331
IS  - 1573-2800 (Electronic)
IS  - 0004-0002 (Linking)
VI  - 40
IP  - 4
DP  - 2011 Aug
TI  - Ethical and regulatory issues with conducting sexuality research with LGBT
      adolescents: a call to action for a scientifically informed approach.
PG  - 673-86
LID - 10.1007/s10508-011-9745-1 [doi]
AB  - Lesbian, gay, bisexual, and transgender (LGBT) adolescents experience disparities
      in mental and sexual health. There is also a lack of research on this population 
      relative to other adolescents, which limits our ability to effectively address
      these health disparities. Researchers may unfortunately avoid conducting research
      with this population because of anticipated or actual experiences with
      difficulties in obtaining IRB approval. A case example is provided to illustrate 
      the ethical and regulatory issues related to research with LGBT adolescents.
      Relevant U.S. federal and local regulations related to research on sexual and
      mental health with adolescents is then reviewed. Data are presented demonstrating
      that requiring parental consent for LGBT youth under age 18 would likely alter
      study result. Data are also presented on participants' appraisals of the risks
      and discomforts associated with research participation. The provision of such
      empirical data on the risks of research participation is consistent with the goal
      of moving the IRB process of risk/benefit assessment from being entirely
      subjective to being evidence-based. Finally, recommendations are provided on how 
      to approach these issues in IRB applications and investigators are called to help
      to build a corpus of scholarship that can advance empirical knowledge in this
      area.
FAU - Mustanski, Brian
AU  - Mustanski B
AD  - IMPACT LGBT Health and Development Program, University of Illinois at Chicago,
      Chicago, IL 60608, USA. brian@impactprogram.org
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Arch Sex Behav
JT  - Archives of sexual behavior
JID - 1273516
SB  - IM
MH  - Adolescent
MH  - Bisexuality
MH  - *Ethics Committees, Research
MH  - *Ethics, Research
MH  - Female
MH  - Homosexuality, Female
MH  - Homosexuality, Male
MH  - Humans
MH  - Male
MH  - Parental Consent
MH  - *Social Control, Formal
MH  - Transsexualism
EDAT- 2011/04/30 06:00
MHDA- 2011/11/01 06:00
CRDT- 2011/04/30 06:00
PHST- 2011/04/30 06:00 [entrez]
PHST- 2011/04/30 06:00 [pubmed]
PHST- 2011/11/01 06:00 [medline]
AID - 10.1007/s10508-011-9745-1 [doi]
PST - ppublish
SO  - Arch Sex Behav. 2011 Aug;40(4):673-86. doi: 10.1007/s10508-011-9745-1.


PMID- 21527966
OWN - NLM
STAT- MEDLINE
DCOM- 20110718
LR  - 20110429
IS  - 0016-3813 (Print)
IS  - 0016-3813 (Linking)
VI  - 147
IP  - 2
DP  - 2011 Mar-Apr
TI  - [Towards a new curriculum for the faculty of medicine of the National University 
      of Mexico (UNAM)].
PG  - 126-31
AB  - The 2010 undergraduate medical degree curriculum at the Faculty of Medicine of
      the Universidad Nacional Autonoma de Mexico (UNAM) is the result of eight years
      of collegiate work, which started under the leadership of Dr. Jose Narro Robles, 
      our current Dean. In order to fulfill the aim of integrally developing a
      physician in the scientific, technical, social and human aspects, this academic
      plan considered the adaptations from a self-assessment test, the opinions
      expressed during academic workshops with professors from different disciplines,
      the work of committees and the results of external evaluations, as well as
      national and international health issues. New areas of knowledge that arose from 
      whirling changes were also included in this plan, new technologies were adopted, 
      the student was considered responsible for his own learning, and the development 
      of unprecedented competences was considered. All this resulted in a departmental 
      infrastructure that is our Faculty of Medicine's strength.An education model was 
      defined by subjects with an outline of two years of basic sciences and
      two-and-a-half years of clinical work aside from internship and social service.
      In order to achieve this and seek a better curricular organization, three
      curricular axes were settled: bio- and sociomedical clinic integration,
      medicine/information technology link, and the ethical/humanistic professional
      combination. We are certain that the 2010 Academic Curriculum will draw the
      graduates we need to train and to the professional requisites for our society in 
      the XXI century.
FAU - Graue Wiechers, Enrique
AU  - Graue Wiechers E
AD  - Facultad de Medicina, Universidad Nacional Autonoma de Mexico (UNAM), Mexico,
      D.F. graue@unam.mx
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Hacia un nuevo Plan de Estudios de la facultad de medicina de la Universidad
      Nacional Autonoma de Mexico (UNAM).
PL  - Mexico
TA  - Gac Med Mex
JT  - Gaceta medica de Mexico
JID - 0010333
SB  - IM
MH  - *Curriculum
MH  - Education, Medical, Undergraduate/*organization & administration
MH  - Mexico
MH  - Organizational Objectives
MH  - Schools, Medical/*organization & administration
EDAT- 2011/04/30 06:00
MHDA- 2011/07/19 06:00
CRDT- 2011/04/30 06:00
PHST- 2011/04/30 06:00 [entrez]
PHST- 2011/04/30 06:00 [pubmed]
PHST- 2011/07/19 06:00 [medline]
PST - ppublish
SO  - Gac Med Mex. 2011 Mar-Apr;147(2):126-31.


PMID- 21527592
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20110429
IS  - 1941-2444 (Electronic)
IS  - 0148-6071 (Linking)
VI  - 35
IP  - 3
DP  - 2011 May
TI  - Ethical issues in nutrition support of severely disabled elderly persons: a guide
      for health professionals.
PG  - 295-302
LID - 10.1177/0148607111405338 [doi]
AB  - Providing or withholding nutrition in severely disabled elderly persons is a
      challenging dilemma for families, health professionals, and institutions. Despite
      limited evidence that nutrition support improves functional status in vulnerable 
      older persons, especially those suffering from dementia, the issue of nutrition
      support in this population is strongly debated. Nutrition might be considered a
      basic need that not only sustains life but provides comfort as well by patients
      and their families. Consequently, the decision to provide or withhold nutrition
      support during medical care is often complex and involves clinical, legal, and
      ethical considerations. This article proposes a guide for health professionals to
      appraise ethical issues related to nutrition support in severely disabled older
      persons. This guide is based on an 8-step process to identify the components of a
      situation, analyze conflicting values that result in the ethical dilemma, and
      eventually reach a consensus for the most relevant plan of care to implement in a
      specific clinical situation. A vignette is presented to illustrate the use of
      this guide when analyzing a clinical situation.
FAU - Monod, Stefanie
AU  - Monod S
AD  - Service of Geriatric Medicine and Geriatric Rehabilitation, University of
      Lausanne Medical Center, Lausanne, Switzerland. Stefanie.Monod-Zorzi@chuv.ch
FAU - Chiolero, Rene
AU  - Chiolero R
FAU - Bula, Christophe
AU  - Bula C
FAU - Benaroyo, Lazare
AU  - Benaroyo L
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - JPEN J Parenter Enteral Nutr
JT  - JPEN. Journal of parenteral and enteral nutrition
JID - 7804134
SB  - IM
CIN - JPEN J Parenter Enteral Nutr. 2011 Jul;35(4):437-9; author reply 440-2. PMID:
      21700964
MH  - Aged
MH  - Dementia/*therapy
MH  - *Disabled Persons
MH  - Dissent and Disputes
MH  - Health Personnel
MH  - Humans
MH  - Nutritional Support/*ethics
MH  - *Practice Guidelines as Topic/standards
MH  - Withholding Treatment/*ethics
EDAT- 2011/04/30 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/04/30 06:00
PHST- 2011/04/30 06:00 [entrez]
PHST- 2011/04/30 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 35/3/295 [pii]
AID - 10.1177/0148607111405338 [doi]
PST - ppublish
SO  - JPEN J Parenter Enteral Nutr. 2011 May;35(3):295-302. doi:
      10.1177/0148607111405338.


PMID- 21527359
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20220408
IS  - 1559-2030 (Electronic)
IS  - 1551-7144 (Linking)
VI  - 32
IP  - 4
DP  - 2011 Jul
TI  - In search of the sample: recent experiences of a trial team in orthodontics.
PG  - 530-4
LID - 10.1016/j.cct.2011.04.005 [doi]
AB  - Randomised clinical trials are commonly undertaken in medical and dental
      research. However, few authors discuss the difficulties associated with such
      studies, including costs, ethical issues and recruitment of an adequate number of
      patients. There is little information available on the number of studies which
      are terminated early as a result of these issues, but it seems likely that at
      least 10% of clinical studies never reach completion. This paper reviews two
      nationally funded clinical studies which were terminated early. It highlights the
      problems associated with patient recruitment and also some issues which may
      benefit researchers undertaking similar studies in the future.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Cunningham, Susan
AU  - Cunningham S
AD  - Department of Orthodontics, UCL Eastman Dental Institute, London, United Kingdom.
      S.Cunningham@eastman.ucl.ac.uk
FAU - Bearn, David
AU  - Bearn D
FAU - Benson, Philip
AU  - Benson P
FAU - Johal, Ama
AU  - Johal A
FAU - Millett, Declan
AU  - Millett D
FAU - O'Brien, Kevin
AU  - O'Brien K
FAU - Luther, Friedy
AU  - Luther F
LA  - eng
PT  - Journal Article
DEP - 20110417
PL  - United States
TA  - Contemp Clin Trials
JT  - Contemporary clinical trials
JID - 101242342
SB  - IM
MH  - *Early Termination of Clinical Trials
MH  - Humans
MH  - Multicenter Studies as Topic
MH  - *Orthodontics
MH  - *Patient Selection
MH  - *Randomized Controlled Trials as Topic
EDAT- 2011/04/30 06:00
MHDA- 2011/11/09 06:00
CRDT- 2011/04/30 06:00
PHST- 2010/10/28 00:00 [received]
PHST- 2011/03/28 00:00 [revised]
PHST- 2011/04/05 00:00 [accepted]
PHST- 2011/04/30 06:00 [entrez]
PHST- 2011/04/30 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - S1551-7144(11)00095-4 [pii]
AID - 10.1016/j.cct.2011.04.005 [doi]
PST - ppublish
SO  - Contemp Clin Trials. 2011 Jul;32(4):530-4. doi: 10.1016/j.cct.2011.04.005. Epub
      2011 Apr 17.


PMID- 21527197
OWN - NLM
STAT- MEDLINE
DCOM- 20110527
LR  - 20110510
IS  - 1527-3792 (Electronic)
IS  - 0022-5347 (Linking)
VI  - 185
IP  - 6 Suppl
DP  - 2011 Jun
TI  - Management of the urinary tract in spina bifida cases varies with lesion level
      and shunt presence.
PG  - 2547-51
LID - 10.1016/j.juro.2011.01.025 [doi]
AB  - PURPOSE: The urinary and gastrointestinal tracts remain an enormous burden to the
      patient with spinal dysraphism. We examined our cases to determine the
      relationship between the level and type of spinal dysraphism, presence of a
      ventricular shunt, and urinary and gastrointestinal tract management. MATERIALS
      AND METHODS: After receiving ethics approval we reviewed the charts of 155
      patients younger than 17 years with spinal dysraphism. We compiled all pertinent 
      neurological, genitourinary and gastrointestinal outcomes from our pediatric and 
      adolescent spina bifida clinic. RESULTS: Of our cohort 43% performed clean
      intermittent catheterization, including significantly more patients with
      myelomeningocele vs those with lipomeningocele or tethered cord (73% vs 19%, p
      <0.01). The intestinocystoplasty rate varied with lesion level and was
      significantly higher in cases of thoracic and thoracolumbar lesions than in cases
      of tethered cord, lipomeningocele and sacral myelomeningocele (p <0.005). Of the 
      patients 52% older than 5 years were continent of urine but this varied
      significantly with lesion level and ventricular shunt presence. The urinary
      continence rate was highest in patients with a tethered spinal cord (57%),
      lipomyelomeningocele (65%) or sacral myelomeningocele (60%) (vs thoracic and
      lumbar myelomeningocele p <0.005). However, there was minimal difference between 
      lumbar and thoracic lesions (25% and 26%, respectively). Of our patients 73% were
      also continent of feces, which did not vary with lesion level. CONCLUSIONS: Our
      data confirm the association of lesion level, a ventricular shunt and continence.
CI  - Copyright (c) 2011 American Urological Association Education and Research, Inc.
      Published by Elsevier Inc. All rights reserved.
FAU - Metcalfe, Peter
AU  - Metcalfe P
AD  - Division of Pediatric Surgery, Department of Surgery, University of Alberta,
      Edmonton, Alberta, Canada. pmetcalf@ualberta.ca
FAU - Gray, Darren
AU  - Gray D
FAU - Kiddoo, Darcie
AU  - Kiddoo D
LA  - eng
PT  - Journal Article
DEP - 20110427
PL  - United States
TA  - J Urol
JT  - The Journal of urology
JID - 0376374
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Fecal Incontinence/etiology/therapy
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Retrospective Studies
MH  - Spinal Dysraphism/*complications/*therapy
MH  - Urinary Incontinence/*etiology/*therapy
MH  - Ventriculoperitoneal Shunt
EDAT- 2011/04/30 06:00
MHDA- 2011/05/28 06:00
CRDT- 2011/04/30 06:00
PHST- 2010/08/23 00:00 [received]
PHST- 2011/04/30 06:00 [entrez]
PHST- 2011/04/30 06:00 [pubmed]
PHST- 2011/05/28 06:00 [medline]
AID - S0022-5347(11)00048-6 [pii]
AID - 10.1016/j.juro.2011.01.025 [doi]
PST - ppublish
SO  - J Urol. 2011 Jun;185(6 Suppl):2547-51. doi: 10.1016/j.juro.2011.01.025. Epub 2011
      Apr 27.


PMID- 21527071
OWN - NLM
STAT- MEDLINE
DCOM- 20110803
LR  - 20141216
IS  - 1839-4345 (Electronic)
IS  - 1034-7674 (Linking)
VI  - 22
IP  - 1-2
DP  - 2011 Apr
TI  - Developing a strategy to promote the generation and effective use of population
      health research for NSW Health: 2011-2015.
PG  - 4-10
LID - 10.1071/NB10066 [doi]
AB  - The Population Health Division of the NSW Department of Health has developed a
      5-year strategy to improve the effectiveness of its resource investment in
      population health research. This paper describes the development of the strategy,
      Promoting the generation and effective use of population health research in NSW: 
      a Strategy for NSW Health 2011-2015. A review of Australian and international
      strategic research documents and stakeholder interviews was conducted to support 
      the development of the strategy. The findings from these two processes influenced
      the structure of the document and supported the inclusion of strategies and
      actions to assist with identifying research priorities, improving communication, 
      enhancing networks and partnerships, supporting workforce development
      initiatives, providing research infrastructure, enhancing research and the use of
      research evidence and streamlining research governance and ethics processes.
      Small group discussions and a detailed review of literature were conducted to
      refine the thinking around four of the more complex aspects of the strategy.
      Finally, a broad consultation process was used to test the face validity of the
      proposed strategy content.
FAU - Biggs, Janice S
AU  - Biggs JS
AD  - NSW Public Health Officer Training Program, NSW Department of Health.
FAU - Stickney, Beth
AU  - Stickney B
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - N S W Public Health Bull
JT  - New South Wales public health bulletin
JID - 9712270
SB  - IM
MH  - Health Services Research/*trends
MH  - New South Wales
MH  - *Program Development
MH  - *Public Health
EDAT- 2011/04/30 06:00
MHDA- 2011/08/04 06:00
CRDT- 2011/04/30 06:00
PHST- 2011/04/30 06:00 [entrez]
PHST- 2011/04/30 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
AID - NB10066 [pii]
AID - 10.1071/NB10066 [doi]
PST - ppublish
SO  - N S W Public Health Bull. 2011 Apr;22(1-2):4-10. doi: 10.1071/NB10066.


PMID- 21526726
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20151119
IS  - 0026-2102 (Print)
IS  - 0026-2102 (Linking)
VI  - 93
IP  - 3
DP  - 2011 Mar
TI  - 'Amalgam-free' dental practices: are they ethical?
PG  - 24
FAU - Maihofer, Michael G
AU  - Maihofer MG
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Mich Dent Assoc
JT  - The Journal of the Michigan Dental Association
JID - 7505621
RN  - 0 (Dental Materials)
RN  - 8049-85-2 (Dental Amalgam)
MH  - *Dental Amalgam
MH  - Dental Materials
MH  - Dentist-Patient Relations/ethics
MH  - Dentists/*ethics
MH  - *Ethics, Dental
MH  - Humans
MH  - Michigan
MH  - Patient Participation
MH  - Practice Patterns, Dentists'/*ethics
MH  - Truth Disclosure/ethics
MH  - United States
EDAT- 2011/04/30 06:00
MHDA- 2011/06/03 06:00
CRDT- 2011/04/30 06:00
PHST- 2011/04/30 06:00 [entrez]
PHST- 2011/04/30 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
PST - ppublish
SO  - J Mich Dent Assoc. 2011 Mar;93(3):24.


PMID- 21503433
OWN - NLM
STAT- MEDLINE
DCOM- 20110803
LR  - 20190907
IS  - 1678-4561 (Electronic)
IS  - 1413-8123 (Linking)
VI  - 16 Suppl 1
DP  - 2011
TI  - [Ethical principles as a home care guide].
PG  - 855-63
LID - S1413-81232011000700017 [pii]
AB  - Home care is a health care strategy that aims to emphasize the autonomy of the
      patient as well as to enhance their functional skills in their home. The aim is
      to reflect the observance of ethical principles in home care, in the form of home
      assistance. The study is exploratory and descriptive, addressing a critical
      review of the literature, according to the analysis of Bardin. Home care is
      becoming indispensable in reducing hospital costs, hospitalization, number of
      hospitalizations and number of clinical complications as well as increased family
      participation in patient care, providing a better quality of life. However, it is
      necessary to take into consideration the purpose and quality of care delivered,
      analyzing it from the perspective of ethical principles in order not to make this
      kind of care only beneficial to one party, but a common good to all subjects
      involved in this care.
FAU - Santos, Leticia Rosa
AU  - Santos LR
AD  - Ministerio da Saude, Brasilia, DF 70058-900. tenenteleticia@yahoo.com.br
FAU - de Leon, Casandra Genoveva Rosales Martins Ponce
AU  - de Leon CG
FAU - Funghetto, Silvana Schwerz
AU  - Funghetto SS
LA  - por
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Principios eticos como norteadores no cuidado domiciliar.
PL  - Brazil
TA  - Cien Saude Colet
JT  - Ciencia & saude coletiva
JID - 9713483
SB  - IM
MH  - Beneficence
MH  - Home Care Services/*ethics
MH  - Humans
MH  - Personal Autonomy
MH  - Social Justice
EDAT- 2011/04/30 06:00
MHDA- 2011/08/04 06:00
CRDT- 2011/04/20 06:00
PHST- 2008/12/05 00:00 [received]
PHST- 2009/06/26 00:00 [accepted]
PHST- 2011/04/20 06:00 [entrez]
PHST- 2011/04/30 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
AID - S1413-81232011000700017 [pii]
AID - 10.1590/s1413-81232011000700017 [doi]
PST - ppublish
SO  - Cien Saude Colet. 2011;16 Suppl 1:855-63. doi: 10.1590/s1413-81232011000700017.


PMID- 21526315
OWN - NLM
STAT- MEDLINE
DCOM- 20111209
LR  - 20191210
IS  - 0717-6163 (Electronic)
IS  - 0034-9887 (Linking)
VI  - 139
IP  - 1
DP  - 2011 Jan
TI  - Teaching of medical ethics: students' perception in different periods of the
      course.
PG  - 36-44
LID - /S0034-98872011000100005 [doi]
AB  - BACKGROUND: Medical ethics is structured to guide doctors towards a better
      professional practice. However, its teaching in medical schools seems to be
      neglected. AIM: To evaluate the perception of Federal University of Sergipe
      medical students about ethical conflicts during their academic practice, in two
      different periods of a medical course. MATERIAL AND METHODS: A cross-sectional,
      analytic and observational study. Using a qualitative approach, analytic
      categories were identified using an open questionnaire answered by two groups of 
      students, before and after attending the medical ethics course. RESULTS: In
      everyday practice, the participants referred embarrassment in front of patients. 
      When considering the relationship with the professional/professor, they
      identified negligence and conflicts of interests in their practice. The students 
      also detected bad infrastructure and professional relationship in public
      services, when compared to private ones. The conflicts experienced by the
      students in their own practice were insecurity, inability to cope with patients' 
      problems and inadequate perception of medical confidentiality limits. According
      to the respondents, contribution of ethics teaching varied from adequate, when it
      was effective to orient their practice and provide confidence, to inadequate or
      absent because of an overall superficial approach. CONCLUSIONS: Major
      deficiencies related to the teaching of medical ethics were identified, pointing 
      to the need to change current medical education model.
FAU - Pimentel, Deborah
AU  - Pimentel D
AD  - Departamento de Medicina, Universidade Federal de Sergipe, Praca Tobias Barreto
      510-1208, bairro Sao Jose, Aracaju, Sergipe, Brazil. deborah@infonet.com.br
FAU - Barbosa de Oliveira, Carla
AU  - Barbosa de Oliveira C
FAU - Vieira, Maria Jesia
AU  - Vieira MJ
LA  - eng
PT  - Journal Article
DEP - 20110411
PL  - Chile
TA  - Rev Med Chil
JT  - Revista medica de Chile
JID - 0404312
SB  - IM
MH  - Adult
MH  - Attitude of Health Personnel
MH  - Brazil
MH  - *Conflict, Psychological
MH  - Cross-Sectional Studies
MH  - Education, Medical, Undergraduate/*standards
MH  - Ethics, Medical/*education
MH  - Female
MH  - Humans
MH  - *Interpersonal Relations
MH  - Male
MH  - Perception
MH  - Students, Medical/*psychology
MH  - Time Factors
MH  - Young Adult
EDAT- 2011/04/29 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/04/29 06:00
PHST- 2011/04/29 06:00 [entrez]
PHST- 2011/04/29 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - S0034-98872011000100005 [pii]
AID - /S0034-98872011000100005 [doi]
PST - ppublish
SO  - Rev Med Chil. 2011 Jan;139(1):36-44. doi: /S0034-98872011000100005. Epub 2011 Apr
      11.


PMID- 21526115
OWN - NLM
STAT- MEDLINE
DCOM- 20110816
LR  - 20211020
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 6
IP  - 4
DP  - 2011 Apr 22
TI  - Neuroethics and fMRI: mapping a fledgling relationship.
PG  - e18537
LID - 10.1371/journal.pone.0018537 [doi]
AB  - Human functional magnetic resonance imaging (fMRI) informs the understanding of
      the neural basis of mental function and is a key domain of ethical enquiry. It
      raises questions about the practice and implications of research, and reflexively
      informs ethics through the empirical investigation of moral judgments. It is at
      the centre of debate surrounding the importance of neuroscience findings for
      concepts such as personhood and free will, and the extent of their practical
      consequences. Here, we map the landscape of fMRI and neuroethics, using citation 
      analysis to uncover salient topics. We find that this landscape is sparsely
      populated: despite previous calls for debate, there are few articles that discuss
      both fMRI and ethical, legal, or social implications (ELSI), and even fewer
      direct citations between the two literatures. Recognizing that practical barriers
      exist to integrating ELSI discussion into the research literature, we argue
      nonetheless that the ethical challenges of fMRI, and controversy over its
      conceptual and practical implications, make this essential.
FAU - Garnett, Alex
AU  - Garnett A
AD  - National Core for Neuroethics, University of British Columbia, Vancouver, British
      Columbia, Canada.
FAU - Whiteley, Louise
AU  - Whiteley L
FAU - Piwowar, Heather
AU  - Piwowar H
FAU - Rasmussen, Edie
AU  - Rasmussen E
FAU - Illes, Judy
AU  - Illes J
LA  - eng
GR  - R01 MH084282/MH/NIMH NIH HHS/United States
GR  - 85117/CAPMC/ CIHR/Canada
GR  - R01MH84282/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110422
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Cluster Analysis
MH  - Databases as Topic
MH  - Humans
MH  - Magnetic Resonance Imaging/*ethics
MH  - Neurosciences/*ethics/legislation & jurisprudence
MH  - Periodicals as Topic
PMC - PMC3081297
EDAT- 2011/04/29 06:00
MHDA- 2011/08/17 06:00
CRDT- 2011/04/29 06:00
PHST- 2011/01/26 00:00 [received]
PHST- 2011/03/03 00:00 [accepted]
PHST- 2011/04/29 06:00 [entrez]
PHST- 2011/04/29 06:00 [pubmed]
PHST- 2011/08/17 06:00 [medline]
AID - 10.1371/journal.pone.0018537 [doi]
PST - epublish
SO  - PLoS One. 2011 Apr 22;6(4):e18537. doi: 10.1371/journal.pone.0018537.


PMID- 21525827
OWN - NLM
STAT- MEDLINE
DCOM- 20120508
LR  - 20120112
IS  - 1827-1596 (Electronic)
IS  - 0375-9393 (Linking)
VI  - 78
IP  - 1
DP  - 2012 Jan
TI  - Managing patients whose family members are physicians.
PG  - 63-8
AB  - The ethical complexities involving physicians who treat their own family members 
      are well known and it is generally accepted that such practice should not occur. 
      We present three anonymous cases in which patient family members who worked as
      physicians complicated the medical care of their hospitalized relatives. When a
      health care worker's family member becomes a hospital patient, the situation can 
      be emotionally charged due to the medical insight the multiple parties have, as
      well as the desire of relatives to be protective of their family members.
      Clinician-relatives need to allow the medical team to assume the role of
      caretaker when their family members are hospitalized. Teams may need to employ
      limit setting in order to ensure fair and consistent care for all patients on the
      ward, and to prevent escalation of emotionally charged situations.
FAU - Bramstedt, K A
AU  - Bramstedt KA
AD  - California Pacific Medical Center, San Francisco, USA. txbioethics@yahoo.com
FAU - Popovich, M
AU  - Popovich M
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20110426
PL  - Italy
TA  - Minerva Anestesiol
JT  - Minerva anestesiologica
JID - 0375272
SB  - IM
CIN - Minerva Anestesiol. 2012 Jan;78(1):13-4. PMID: 21654594
MH  - Abdominal Pain/therapy
MH  - Accidental Falls
MH  - Aged, 80 and over
MH  - Family/*psychology
MH  - Fatal Outcome
MH  - Female
MH  - Hematoma, Subdural, Acute/etiology/therapy
MH  - Humans
MH  - Liver Failure, Acute/complications/therapy
MH  - Liver Transplantation/ethics
MH  - Medical Futility
MH  - Patient Care Management/*ethics
MH  - Physicians/*ethics
MH  - Prognosis
MH  - Shock, Septic/therapy
EDAT- 2011/04/29 06:00
MHDA- 2012/05/09 06:00
CRDT- 2011/04/29 06:00
PHST- 2011/04/29 06:00 [entrez]
PHST- 2011/04/29 06:00 [pubmed]
PHST- 2012/05/09 06:00 [medline]
AID - R02116569 [pii]
PST - ppublish
SO  - Minerva Anestesiol. 2012 Jan;78(1):63-8. Epub 2011 Apr 26.


PMID- 21525798
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20110428
IS  - 1565-4753 (Print)
IS  - 1565-4753 (Linking)
VI  - 8
IP  - 3
DP  - 2011 Mar
TI  - Disorders of sex development-when and how to tell the patient.
PG  - 213-7; quiz 223
AB  - Physicians and other providers are often confronted with difficult decisions in
      the area of disclosure. This article examines a hypothetical situation relevant
      to the practice of pediatric endocrinology. The parents of a child with a
      disorder of sex development (DSD) wish the physician to treat their child, but
      without revealing key medical information to the child. Herein, we will explore
      the legal and ethical responsibilities of a provider to disclose information to
      an under-age DSD patient and to provide insight on when and how to tell the
      patient.
FAU - Austin, Juliana
AU  - Austin J
AD  - Department of Pediatrics, Division of Pediatric Endocrinology, Long Beach
      Memorial and Miller Children's Hospital, Long Beach, CA. julianala@gmail.com
FAU - Tamar-Mattis, Anne
AU  - Tamar-Mattis A
FAU - Mazur, Tom
AU  - Mazur T
FAU - Henwood, Maria J
AU  - Henwood MJ
FAU - Rossi, Wilma C
AU  - Rossi WC
LA  - eng
PT  - Journal Article
PL  - Israel
TA  - Pediatr Endocrinol Rev
JT  - Pediatric endocrinology reviews : PER
JID - 101202124
SB  - IM
MH  - Adolescent
MH  - Child
MH  - *Disclosure/ethics/legislation & jurisprudence
MH  - *Disorders of Sex Development/diagnosis
MH  - *Endocrinology/ethics/legislation & jurisprudence
MH  - Female
MH  - Humans
MH  - Informed Consent
MH  - Male
MH  - Parents
MH  - Patient Rights
MH  - *Pediatrics/ethics/legislation & jurisprudence
MH  - Physician-Patient Relations
MH  - Truth Disclosure/ethics
EDAT- 2011/04/29 06:00
MHDA- 2011/06/03 06:00
CRDT- 2011/04/29 06:00
PHST- 2011/04/29 06:00 [entrez]
PHST- 2011/04/29 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
PST - ppublish
SO  - Pediatr Endocrinol Rev. 2011 Mar;8(3):213-7; quiz 223.


PMID- 21525726
OWN - NLM
STAT- MEDLINE
DCOM- 20111031
LR  - 20181201
IS  - 1423-0356 (Electronic)
IS  - 0025-7931 (Linking)
VI  - 82
IP  - 1
DP  - 2011
TI  - A randomized controlled trial of hot versus cold biopsy forceps in the diagnosis 
      of endobronchial lesions: strengths, pitfalls, and ethics points in the study
      designing.
PG  - 65; author reply 66
LID - 10.1159/000326919 [doi]
FAU - Seifirad, Soroush
AU  - Seifirad S
LA  - eng
PT  - Letter
PT  - Comment
DEP - 20110427
PL  - Switzerland
TA  - Respiration
JT  - Respiration; international review of thoracic diseases
JID - 0137356
SB  - IM
CON - Respiration. 2011;81(2):129-33. PMID: 20980720
MH  - Bronchi/*pathology
MH  - *Bronchoscopy
MH  - *Electrocoagulation
MH  - Female
MH  - Humans
MH  - Male
MH  - Postoperative Hemorrhage/*etiology
EDAT- 2011/04/29 06:00
MHDA- 2011/11/01 06:00
CRDT- 2011/04/29 06:00
PHST- 2011/04/29 06:00 [entrez]
PHST- 2011/04/29 06:00 [pubmed]
PHST- 2011/11/01 06:00 [medline]
AID - 000326919 [pii]
AID - 10.1159/000326919 [doi]
PST - ppublish
SO  - Respiration. 2011;82(1):65; author reply 66. doi: 10.1159/000326919. Epub 2011
      Apr 27.


PMID- 21525206
OWN - NLM
STAT- MEDLINE
DCOM- 20110926
LR  - 20181201
IS  - 1521-0103 (Electronic)
IS  - 0022-3565 (Linking)
VI  - 338
IP  - 2
DP  - 2011 Aug
TI  - Paw inflammation model in dogs for preclinical pharmacokinetic/pharmacodynamic
      investigations of nonsteroidal anti-inflammatory drugs.
PG  - 548-58
LID - 10.1124/jpet.110.178350 [doi]
AB  - The goal of the present study was to develop and validate a new canine model of
      inflammation. The motivation was to make available a scientifically appropriate
      and ethically acceptable model to conduct pharmacokinetic/pharmacodynamic
      investigations for testing nonsteroidal anti-inflammatory drugs in dogs. A
      kaolin-induce paw inflammation model previously developed in cats was adapted to 
      the dog. The paw inflammation developed within a few hours, reached maximum
      values 24 h and up to 3 days after kaolin administration, and then progressively 
      resolved over 2 months. Five end points of clinical interest (body temperature,
      creeping time under a tunnel, paw withdrawal latency to a standardized thermal
      stimulus, lameness score, and vertical force developed during walking on a force 
      plate) were measured regularly over the next 24 h and beyond to characterize the 
      time development of the inflammation either in control conditions (placebo
      period) or after the administration of meloxicam (test period) according to a
      crossover design. Pharmacodynamic data were modeled using an indirect response
      pharmacokinetic/pharmacodynamic model. This model described three effects of
      meloxicam, namely, classic anti-inflammatory, analgesic, and antipyretic effects.
      The mean plasma meloxicam IC(50) values were 210 ng/ml for the antipyretic
      effect, 390 ng/ml for the analgesic effect, and 546 ng/ml for the vertical force 
      exerted by the paw on the ground as measured by force plates. These in vivo
      IC(50) values require approximately 80 (antipyretic effect) to 90% (all other
      effects) cyclooxygenase-2 inhibition as calculated ex vivo whole-blood assay
      data.
FAU - Jeunesse, E C
AU  - Jeunesse EC
AD  - TOXALIM, Institut National de la Recherche Agronomique, Toulouse, France.
FAU - Bargues, I A
AU  - Bargues IA
FAU - Toutain, C E
AU  - Toutain CE
FAU - Lacroix, M Z
AU  - Lacroix MZ
FAU - Letellier, I M
AU  - Letellier IM
FAU - Giraudel, J M
AU  - Giraudel JM
FAU - Toutain, P L
AU  - Toutain PL
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110427
PL  - United States
TA  - J Pharmacol Exp Ther
JT  - The Journal of pharmacology and experimental therapeutics
JID - 0376362
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Thiazines)
RN  - 0 (Thiazoles)
RN  - VG2QF83CGL (Meloxicam)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/*pharmacokinetics/*therapeutic use
MH  - *Disease Models, Animal
MH  - Dogs
MH  - Drug Evaluation, Preclinical/methods
MH  - Female
MH  - Foot/pathology
MH  - Inflammation/drug therapy/metabolism/pathology
MH  - Lameness, Animal/*drug therapy/metabolism/pathology
MH  - Male
MH  - Meloxicam
MH  - Pain Measurement/drug effects/methods
MH  - Random Allocation
MH  - Reproducibility of Results
MH  - Thiazines/*pharmacokinetics/*therapeutic use
MH  - Thiazoles/*pharmacokinetics/*therapeutic use
EDAT- 2011/04/29 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/04/29 06:00
PHST- 2011/04/29 06:00 [entrez]
PHST- 2011/04/29 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - jpet.110.178350 [pii]
AID - 10.1124/jpet.110.178350 [doi]
PST - ppublish
SO  - J Pharmacol Exp Ther. 2011 Aug;338(2):548-58. doi: 10.1124/jpet.110.178350. Epub 
      2011 Apr 27.


PMID- 21525093
OWN - NLM
STAT- MEDLINE
DCOM- 20110711
LR  - 20181023
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 342
DP  - 2011 Apr 27
TI  - The lawyer's brief on ethics.
PG  - d1815
LID - 10.1136/bmj.d1815 [doi]
LID - bmj.d1815 [pii]
FAU - Sokol, Daniel K
AU  - Sokol DK
AD  - daniel.sokol@talk21.com
LA  - eng
PT  - Journal Article
DEP - 20110427
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
SB  - IM
MH  - *Codes of Ethics
MH  - Confidentiality
MH  - *Ethics, Professional
MH  - *Lawyers
EDAT- 2011/04/29 06:00
MHDA- 2011/07/12 06:00
CRDT- 2011/04/29 06:00
PHST- 2011/04/29 06:00 [entrez]
PHST- 2011/04/29 06:00 [pubmed]
PHST- 2011/07/12 06:00 [medline]
AID - 10.1136/bmj.d1815 [doi]
PST - epublish
SO  - BMJ. 2011 Apr 27;342:d1815. doi: 10.1136/bmj.d1815.


PMID- 21524791
OWN - NLM
STAT- MEDLINE
DCOM- 20110926
LR  - 20151119
IS  - 1532-3102 (Electronic)
IS  - 0143-4004 (Linking)
VI  - 32
IP  - 7
DP  - 2011 Jul
TI  - Ethical aspects in placental perfusion studies: views of the researchers.
PG  - 511-5
LID - 10.1016/j.placenta.2011.04.006 [doi]
AB  - Within the EU-project NewGeneris human placental perfusion has been used for
      predicting fetal exposure to food carcinogens. Within the work package of ethical
      aspects of the research, we studied opinions of the researchers (n = 23) who
      carried out perfusions of human placenta. Data were collected by focus group
      interviews (n = 12) and an open-ended questionnaire (n =19 of which 8 were also
      attending the group session) from scientists representing 9 different
      nationalities. Both types of data were analysed together thematically and with
      data triangulation. Studied researchers considered communication between all
      stakeholders extremely important. Good communication was considered a
      prerequisite for the recruitment of mothers to donate the placenta, as well as
      for the process of getting the informed consent. Voluntariness, confidentiality
      and societal meaning were mentioned as important by all studied researchers.
      Educating the hospital personnel was regarded as essential in order to provide
      the best possible information to the mothers. The researchers also pointed out
      that cultural aspects should be respected, and that in Western thinking placenta 
      is mostly considered as waste. Some researchers suggested that current guidelines
      and processes for obtaining informed consent should be reviewed also from a
      cultural perspective. With the development of biobanks, the use of human tissues,
      including placenta will most probably increase in the future, and the awareness
      of ethical considerations both in legislation and in practice need support. Thus,
      continuous effort for better research ethics is essential and requires research
      on research ethics.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Halkoaho, A
AU  - Halkoaho A
AD  - University of Eastern Finland. arja.halkoaho@kuh.fi
FAU - Pietila, A-M
AU  - Pietila AM
FAU - Vahakangas, K
AU  - Vahakangas K
LA  - eng
PT  - Journal Article
DEP - 20110427
PL  - Netherlands
TA  - Placenta
JT  - Placenta
JID - 8006349
SB  - IM
MH  - Communication
MH  - *Ethics, Research
MH  - Female
MH  - Focus Groups
MH  - Human Experimentation/ethics
MH  - Humans
MH  - Informed Consent/ethics
MH  - Midwifery
MH  - Placenta/*physiology
MH  - Pregnancy
MH  - Research Personnel/ethics
MH  - Surveys and Questionnaires
MH  - Tissue and Organ Procurement/*ethics
EDAT- 2011/04/29 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/04/29 06:00
PHST- 2011/03/06 00:00 [received]
PHST- 2011/04/06 00:00 [revised]
PHST- 2011/04/06 00:00 [accepted]
PHST- 2011/04/29 06:00 [entrez]
PHST- 2011/04/29 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - S0143-4004(11)00145-7 [pii]
AID - 10.1016/j.placenta.2011.04.006 [doi]
PST - ppublish
SO  - Placenta. 2011 Jul;32(7):511-5. doi: 10.1016/j.placenta.2011.04.006. Epub 2011
      Apr 27.


PMID- 21524678
OWN - NLM
STAT- MEDLINE
DCOM- 20110816
LR  - 20151119
IS  - 1879-3185 (Electronic)
IS  - 0300-483X (Linking)
VI  - 285
IP  - 3
DP  - 2011 Jul 29
TI  - Comparative protective effects of HI-6 and MMB-4 against organophosphorous nerve 
      agent poisoning.
PG  - 90-6
LID - 10.1016/j.tox.2011.04.006 [doi]
AB  - The oximes pralidoxime (2-PAM), its dimethanesulphonate salt derivative P2S, and 
      obidoxime (toxogonin) are currently licensed and fielded for the treatment of
      chemical warfare (CW) organophosphorous (OP) nerve agent poisoning. While they
      are effective against several of the identified threat CW OP agents, they have
      little efficacy against others such as soman (GD) and cyclosarin (CF). In
      addition, they are also significantly less effective than other investigational
      oximes against the nerve agent known as Russian VX (RVX). Among the oximes
      currently being investigated, two in particular, HI-6 (asoxime) and MMB-4
      (ICD-039, methoxime) have been proposed as replacement therapies for the
      currently licensed oximes. HI-6 has been safely used in individuals to treat OP
      insecticide poisoning, as well as in human volunteers, although its efficacy
      against OP nerve agent poisoning in humans cannot be demonstrated due to ethical 
      considerations. It is currently available for use in defined military settings in
      Canada, Sweden and the Czech Republic, and is also under development in a number 
      of other countries. The oxime MMB-4 has not yet been studied clinically, but is
      fielded by the Czech Republic, and is being developed by the United States armed 
      services as a replacement for the currently fielded 2-PAM. This review compares
      the effectiveness of HI-6 and MMB-4 against nerve agent threats where comparisons
      can be made. HI-6 has been demonstrated to be generally a superior reactivator of
      nerve agent inhibited enzyme, particularly with human and non-human primate
      derived enzyme, and has also shown better protective effects against the
      lethality of most OP agents in a variety of species. Both compounds appear to be 
      clearly superior to the available oximes, obidoxime and 2-PAM.
CI  - Crown Copyright (c) 2011. Published by Elsevier Ireland Ltd. All rights reserved.
FAU - Lundy, Paul M
AU  - Lundy PM
AD  - Therapeutic Response Ltd., Medicine Hat, Alberta, Canada. PJlundy@shaw.ca
FAU - Hamilton, Murray G
AU  - Hamilton MG
FAU - Sawyer, Thomas W
AU  - Sawyer TW
FAU - Mikler, John
AU  - Mikler J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
DEP - 20110415
PL  - Ireland
TA  - Toxicology
JT  - Toxicology
JID - 0361055
RN  - 0 (Antidotes)
RN  - 0 (Chemical Warfare Agents)
RN  - 0 (Organophosphates)
RN  - 0 (Organophosphorus Compounds)
RN  - 0 (Oximes)
RN  - 0 (Pyridinium Compounds)
RN  - 61444-84-6 (N,N'-monomethylenebis(pyridiniumaldoxime))
RN  - 96-64-0 (Soman)
RN  - B4XG72QGFM (Sarin)
RN  - HUV88P6SJS (asoxime chloride)
RN  - S45M750QSH (tabun)
RN  - VM36F9N236 (cyclohexyl methylphosphonofluoridate)
SB  - IM
MH  - Antidotes/pharmacology/*therapeutic use
MH  - Chemical Warfare Agents/*poisoning
MH  - Humans
MH  - *Organophosphate Poisoning
MH  - Organophosphates/antagonists & inhibitors
MH  - Organophosphorus Compounds/antagonists & inhibitors
MH  - Oximes/pharmacology/*therapeutic use
MH  - Pyridinium Compounds/pharmacology/*therapeutic use
MH  - Sarin/antagonists & inhibitors/poisoning
MH  - Soman/antagonists & inhibitors/poisoning
EDAT- 2011/04/29 06:00
MHDA- 2011/08/17 06:00
CRDT- 2011/04/29 06:00
PHST- 2011/01/11 00:00 [received]
PHST- 2011/04/04 00:00 [revised]
PHST- 2011/04/08 00:00 [accepted]
PHST- 2011/04/29 06:00 [entrez]
PHST- 2011/04/29 06:00 [pubmed]
PHST- 2011/08/17 06:00 [medline]
AID - S0300-483X(11)00145-4 [pii]
AID - 10.1016/j.tox.2011.04.006 [doi]
PST - ppublish
SO  - Toxicology. 2011 Jul 29;285(3):90-6. doi: 10.1016/j.tox.2011.04.006. Epub 2011
      Apr 15.


PMID- 21524604
OWN - NLM
STAT- MEDLINE
DCOM- 20110823
LR  - 20110428
IS  - 1558-1527 (Electronic)
IS  - 1558-1527 (Linking)
VI  - 82
IP  - 5
DP  - 2011 May
TI  - Adverse action reports against optometrists: perspectives from the National
      Practitioner Data Bank over 18 years.
PG  - 318-21
LID - 10.1016/j.optm.2010.09.015 [doi]
AB  - PURPOSE: The aim of this analysis is to describe characteristics of National
      Provider Data Bank (NPDB) adverse action reports against optometrists. METHODS:
      NPDB public use files were analyzed for details of reported optometrist adverse
      actions from 1991 through 2008. Types of actions, basis for actions, and
      reporting source were identified, along with geographic and demographic data.
      RESULTS: Between 1991 and 2008, a total of 216 adverse actions against
      optometrists were recorded nationally. Exclusion from Medicare or another
      government program accounted for 92% of all reports; the remaining 8% were
      related to unfavorable privileging decisions. Most cases with identifiable
      explanations were the result of either defaults on student loans (55%) or charges
      of fraud and abuse (39%). Over two thirds of all reports originated in just 12
      states, and 74% involved younger optometrists (age 30 to 49). Repeat offenses
      were reported for 38% of sanctioned optometrists. CONCLUSION: NPDB reported
      adverse actions against optometrists are infrequent but most commonly involve
      exclusion from Medicare or similar government programs. Student loan default,
      particularly by younger optometrists, is the single most common cause, followed
      by allegations of fraud and abuse. Because this national database is permanently 
      archived and widely used by licensing and credentialing bodies, optometrists
      should endeavor to be ethically responsible and strive to avoid behaviors that
      mandate such action reports.
CI  - Published by Elsevier Inc.
FAU - Duszak, Robert S
AU  - Duszak RS
AD  - Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA.
      bduszak@mac.com
FAU - Duszak, Richard Jr
AU  - Duszak R Jr
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Optometry
JT  - Optometry (St. Louis, Mo.)
JID - 100912421
SB  - IM
MH  - Adult
MH  - Fraud
MH  - Government Programs
MH  - Humans
MH  - Mandatory Reporting
MH  - Medicare Assignment
MH  - Middle Aged
MH  - National Practitioner Data Bank/*statistics & numerical data
MH  - Optometry/*statistics & numerical data
MH  - Time Factors
MH  - Training Support
MH  - United States
EDAT- 2011/04/29 06:00
MHDA- 2011/08/24 06:00
CRDT- 2011/04/29 06:00
PHST- 2010/06/11 00:00 [received]
PHST- 2010/09/01 00:00 [revised]
PHST- 2010/09/08 00:00 [accepted]
PHST- 2011/04/29 06:00 [entrez]
PHST- 2011/04/29 06:00 [pubmed]
PHST- 2011/08/24 06:00 [medline]
AID - S1529-1839(11)00014-5 [pii]
AID - 10.1016/j.optm.2010.09.015 [doi]
PST - ppublish
SO  - Optometry. 2011 May;82(5):318-21. doi: 10.1016/j.optm.2010.09.015.


PMID- 21524390
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20110428
IS  - 1944-7930 (Electronic)
IS  - 1539-6509 (Linking)
VI  - 11
IP  - 59
DP  - 2011 Apr
TI  - Regulatory considerations for developing drugs for rare diseases: orphan
      designations and early phase clinical trials.
PG  - 367-75
AB  - The development of drug and biological products intended to treat rare diseases
      (Orphan diseases) is one of the fastest growing areas of clinical research, and
      also one of the most challenging. This article provides an introduction to two
      important regulatory considerations for Orphan drugs: Orphan status designations 
      and general considerations for the administration of investigational agents in
      early phase clinical trials. Incentives available to orphan drug developers under
      the Orphan Drug Act (ODA) and requirements for obtaining an orphan status
      designation are discussed. An introductory overview of ethical and statutory
      considerations for investigational drugs, requirements for initiating
      investigational new drug applications (INDs), and sources of information and
      advice from the US Food and Drug Administration (FDA) are also described.
FAU - Pariser, Anne R
AU  - Pariser AR
AD  - Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug
      Administration, Silver Spring, Maryland 20993, USA.
FAU - Xu, Kui
AU  - Xu K
FAU - Milto, John
AU  - Milto J
FAU - Cote, Timothy R
AU  - Cote TR
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Discov Med
JT  - Discovery medicine
JID - 101250006
SB  - IM
MH  - Animals
MH  - Clinical Trials as Topic/*legislation & jurisprudence
MH  - Drug Discovery/*legislation & jurisprudence
MH  - Humans
MH  - *Legislation, Drug
MH  - Orphan Drug Production/*legislation & jurisprudence
MH  - Rare Diseases/*drug therapy
EDAT- 2011/04/29 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/04/29 06:00
PHST- 2011/04/29 06:00 [entrez]
PHST- 2011/04/29 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
PST - ppublish
SO  - Discov Med. 2011 Apr;11(59):367-75.


PMID- 21523983
OWN - NLM
STAT- MEDLINE
DCOM- 20110525
LR  - 20110428
IS  - 1551-8892 (Print)
IS  - 1551-8892 (Linking)
IP  - 97
DP  - 2011 Spring
TI  - Ethics and lessons learned in transport.
PG  - 22-4
FAU - Tallbear, Sandra
AU  - Tallbear S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Midwifery Today Int Midwife
JT  - Midwifery today with international midwife
JID - 100888783
MH  - Anecdotes as Topic
MH  - Decision Making
MH  - Ethics, Nursing
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Midwifery/*ethics
MH  - *Nurse's Role
MH  - Perinatal Care/*ethics
MH  - Pregnancy
MH  - Pregnancy Outcome
MH  - Transportation of Patients/*ethics
EDAT- 2011/04/29 06:00
MHDA- 2011/05/26 06:00
CRDT- 2011/04/29 06:00
PHST- 2011/04/29 06:00 [entrez]
PHST- 2011/04/29 06:00 [pubmed]
PHST- 2011/05/26 06:00 [medline]
PST - ppublish
SO  - Midwifery Today Int Midwife. 2011 Spring;(97):22-4.


PMID- 21518750
OWN - NLM
STAT- MEDLINE
DCOM- 20110816
LR  - 20110426
IS  - 1532-2092 (Electronic)
IS  - 1099-5129 (Linking)
VI  - 13 Suppl 2
DP  - 2011 May
TI  - Health technology assessment: what is it? Current status and perspectives in the 
      field of electrophysiology.
PG  - ii49-53
LID - 10.1093/europace/eur083 [doi]
AB  - Health technology assessment (HTA) is the multidisciplinary field of policy
      analysis that studies medical, social, ethical, and economic implications of the 
      development, diffusion, and use of health technologies. Its worldwide diffusion
      needs to be understood in the context of evidence-based healthcare delivery
      policy, and it is strongly driven by the search for new cost-containment policies
      by the governments of universal healthcare systems. This article presents the
      three main pillars of HTA: evaluating comparative effectiveness,
      cost-effectiveness, and organizational impact. While comparative analysis is more
      familiar to cardiologists, cost-effectiveness and organizational studies are less
      widely known because they expand the perspective of the evaluation to
      institutional settings and society at large and require significant
      inter-disciplinary work. Sound economic and organizational studies that extend
      comparative effectiveness studies may facilitate dialogue between medical science
      and policymaking.
FAU - Fattore, Giovanni
AU  - Fattore G
AD  - Department of Institutional Analysis and Public Management, Centre for Research
      in Healthcare Management (CERGAS), Universita Bocconi, Via Roentgen 1, Milano
      20136, Italy.
FAU - Maniadakis, Nikos
AU  - Maniadakis N
FAU - Mantovani, Lorenzo G
AU  - Mantovani LG
FAU - Boriani, Giuseppe
AU  - Boriani G
LA  - eng
PT  - Journal Article
PL  - England
TA  - Europace
JT  - Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal 
      of the working groups on cardiac pacing, arrhythmias, and cardiac cellular
      electrophysiology of the European Society of Cardiology
JID - 100883649
SB  - IM
MH  - Biomedical Technology/*trends
MH  - Electrophysiologic Techniques, Cardiac/*trends
MH  - Europe
MH  - Forecasting
MH  - Technology Assessment, Biomedical/*trends
EDAT- 2011/04/29 06:00
MHDA- 2011/08/17 06:00
CRDT- 2011/04/27 06:00
PHST- 2011/04/27 06:00 [entrez]
PHST- 2011/04/29 06:00 [pubmed]
PHST- 2011/08/17 06:00 [medline]
AID - eur083 [pii]
AID - 10.1093/europace/eur083 [doi]
PST - ppublish
SO  - Europace. 2011 May;13 Suppl 2:ii49-53. doi: 10.1093/europace/eur083.


PMID- 21503427
OWN - NLM
STAT- MEDLINE
DCOM- 20110803
LR  - 20190907
IS  - 1678-4561 (Electronic)
IS  - 1413-8123 (Linking)
VI  - 16 Suppl 1
DP  - 2011
TI  - [Terms of informed consent for users of dental clinics in Brazil: legal and
      ethical issues].
PG  - 805-12
LID - S1413-81232011000700011 [pii]
AB  - The consent of patient before the beginning of any procedure has to be a
      respected condition, without any exception. It is necessary the patients to be
      aware of their health status, their specific needs, the intention of each
      treatment, the alternatives plans (including no treatment), to know their
      prognostic, risks, consequences, limitations, and to be aware of their
      responsibilities and those of your dentist, resulting in the success of the
      treatment. The Informed Consent (TCLE) aims to fortify and to clarify the
      position of the patient, being established the rights and duties of both parts - 
      patient and professional. The integral knowledge of the treatment will minimize
      the anxiety of the patient and treatment complications, and promote greater
      quality of dental services and improve the satisfaction of both dentist and
      patient. However, there are few articles in Brazil about this, but there are some
      ethics problems involving dental clinics regarding this document of information
      for the patient. Therefore, the aim of this work is to carry through a critical
      revision on the subject demonstrating the importance of the TCLE in the Brazilian
      dental clinics.
FAU - Sales-Peres, Silvia Helena de Carvalho
AU  - Sales-Peres SH
AD  - Departamento de Odontopediatria, Ortodontia e Saude Coletiva, Faculdade de
      Odontologia de Bauru, Universidade de Sao Paulo, Bauru, SP 17012-101.
      shcperes@usp.br
FAU - Sales-Peres, Arsenio
AU  - Sales-Peres A
FAU - Eleuterio, Adriana Silveira de Lima
AU  - Eleuterio AS
FAU - de Oliveira, Jose Luiz Goes
AU  - de Oliveira JL
FAU - Gigliotti, Mariana Pracucio
AU  - Gigliotti MP
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Termo de consentimento livre e esclarecido aos usuarios de clinicas odontologicas
      brasileiras: aspectos eticos e legais.
PL  - Brazil
TA  - Cien Saude Colet
JT  - Ciencia & saude coletiva
JID - 9713483
SB  - IM
MH  - Brazil
MH  - *Dental Clinics
MH  - Humans
MH  - Informed Consent/*ethics/*legislation & jurisprudence
EDAT- 2011/04/29 06:00
MHDA- 2011/08/04 06:00
CRDT- 2011/04/20 06:00
PHST- 2007/08/31 00:00 [received]
PHST- 2008/05/30 00:00 [accepted]
PHST- 2011/04/20 06:00 [entrez]
PHST- 2011/04/29 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
AID - S1413-81232011000700011 [pii]
AID - 10.1590/s1413-81232011000700011 [doi]
PST - ppublish
SO  - Cien Saude Colet. 2011;16 Suppl 1:805-12. doi: 10.1590/s1413-81232011000700011.


PMID- 21503426
OWN - NLM
STAT- MEDLINE
DCOM- 20110803
LR  - 20190907
IS  - 1678-4561 (Electronic)
IS  - 1413-8123 (Linking)
VI  - 16 Suppl 1
DP  - 2011
TI  - [The importance of the insertion of the nutritionist on the Family Health
      Strategy].
PG  - 797-804
LID - S1413-81232011000700010 [pii]
AB  - The Family Health Strategy has as its main purpose to reorganize the practice of 
      attention to health in new bases and to substitute the traditional model existing
      in Brazil. The new curriculum guidelines to graduate health professionals propose
      a general formation as well as ethics, having as its main focus the largest
      approach to the local health services. However, Nutrition still does not present 
      a regulation for an active participation in the Family Health Strategy.
      Considering this fact, the Family Health Strategy is directly linked to people's 
      welfare in many aspects (social, nutritional, psychological, etc). Therefore,
      this work intends to present the importance of the insertion of a nutritionist in
      the Family Health Strategy for the integrality of health actions. The conclusion 
      is that nutritionist is fully qualified to work in the Family Health Strategy,
      because the absence of this professional is against the principle of the
      integrality of the health actions, as it is evident that no other health
      professional possesses education to work with food and nutrition within the
      communities and this presence would contribute to promote people's health.
FAU - de Geus, Laryssa Maria Mendes
AU  - de Geus LM
AD  - Curso de Nutricao, Centro de Ensino Superior dos Campos Gerais, Ponta Grossa, PR 
      84030-000. laryssamendes@yahoo.com.br
FAU - Maciel, Cintia Sovek
AU  - Maciel CS
FAU - Burda, Isabel Cristina Araujo
AU  - Burda IC
FAU - Daros, Sara Jedida
AU  - Daros SJ
FAU - Batistel, Sunali
AU  - Batistel S
FAU - Martins, Thiciane Corina Antunes
AU  - Martins TC
FAU - Ferreira, Vanessa Aparecida
AU  - Ferreira VA
FAU - Ditterich, Rafael Gomes
AU  - Ditterich RG
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - A importancia na insercao do nutricionista na Estrategia Saude da Familia.
PL  - Brazil
TA  - Cien Saude Colet
JT  - Ciencia & saude coletiva
JID - 9713483
SB  - IM
MH  - Brazil
MH  - *Dietetics
MH  - *Family Health
MH  - *Government Programs
MH  - Health Policy
MH  - Humans
MH  - Primary Health Care
EDAT- 2011/04/29 06:00
MHDA- 2011/08/04 06:00
CRDT- 2011/04/20 06:00
PHST- 2008/02/08 00:00 [received]
PHST- 2008/11/30 00:00 [accepted]
PHST- 2011/04/20 06:00 [entrez]
PHST- 2011/04/29 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
AID - S1413-81232011000700010 [pii]
AID - 10.1590/s1413-81232011000700010 [doi]
PST - ppublish
SO  - Cien Saude Colet. 2011;16 Suppl 1:797-804. doi: 10.1590/s1413-81232011000700010.


PMID- 21503420
OWN - NLM
STAT- MEDLINE
DCOM- 20110803
LR  - 20190907
IS  - 1678-4561 (Electronic)
IS  - 1413-8123 (Linking)
VI  - 16 Suppl 1
DP  - 2011
TI  - [Education: new frontier of bioethics].
PG  - 735-45
LID - S1413-81232011000700004 [pii]
AB  - This study analyses the opinion of teachers regarding the inclusion of contents
      on Bioethics in the curricular structure of high school. Six schools were
      selected: three public and three private in the main administrative region of
      Brasilia. In a universe of 340 teachers, 150 joined the research. They were given
      a questionnaire with answers about the existence or not of curricular contents
      related to the construction of values in the students. The second phase counted
      with 140 teachers out of those who joined the first part of the research. These
      teachers received a text briefly explaining what Bioethics is with a closed space
      for answering if the inclusion of a new discipline on Bioethics would help
      creating values and ethics attitudes in the students. There was space for
      justifying this answer. Data analysis showed that: (a) the school has not carried
      out its role as an instrument of a critical vision; (b) according to the
      teachers, this is the result of the absence of a discipline focused on the
      approach to ethic questions; (c) 51% of the respondents took sides with the
      inclusion of a discipline that deals with Bioethics in the curricular structure
      of high school because they believe that it would help the construction of the
      students' moral values and affirmative attitudes.
FAU - Pires, Jansen Ribeiro
AU  - Pires JR
AD  - Programa de Pos-Graduacao em Bioetica, Nucleo de Estudos e Pesquisas em Bioetica,
      Catedra UNESCO de Bioetica, Brasilia, DF 70919-970. bioetica@unb.br
FAU - Garrafa, Volnei
AU  - Garrafa V
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Educacao: nova fronteira da bioetica.
PL  - Brazil
TA  - Cien Saude Colet
JT  - Ciencia & saude coletiva
JID - 9713483
SB  - IM
MH  - Bioethics/*education
MH  - Brazil
MH  - Curriculum
MH  - Faculty
MH  - Schools
EDAT- 2011/04/29 06:00
MHDA- 2011/08/04 06:00
CRDT- 2011/04/20 06:00
PHST- 2008/04/18 00:00 [received]
PHST- 2008/10/31 00:00 [accepted]
PHST- 2011/04/20 06:00 [entrez]
PHST- 2011/04/29 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
AID - S1413-81232011000700004 [pii]
AID - 10.1590/s1413-81232011000700004 [doi]
PST - ppublish
SO  - Cien Saude Colet. 2011;16 Suppl 1:735-45. doi: 10.1590/s1413-81232011000700004.


PMID- 21503419
OWN - NLM
STAT- MEDLINE
DCOM- 20110803
LR  - 20190907
IS  - 1678-4561 (Electronic)
IS  - 1413-8123 (Linking)
VI  - 16 Suppl 1
DP  - 2011
TI  - [Ethical issues in a market dispute between clinical laboratories and a health
      plan: case report].
PG  - 731-4
LID - S1413-81232011000700003 [pii]
AB  - In Brazil the private health plans appear as an alternative to the public health 
      assistance. This segment suffered great intensification in the seventies and
      eighties, culminating in the entry of large insurance company in the scenario of 
      supplementary medicine. Quickly, the service providers associated with these
      insurance companies, consolidating them in the market and triggering a
      relationship of dependency. This article analyzed, in the form of a case report, 
      a marketing dispute between clinical laboratories and a health plan, emphasizing 
      the moral and ethical aspects involved in this episode.
FAU - Pinheiro, Malone Santos
AU  - Pinheiro MS
AD  - Laboratorio Central de Biomedicina, Centro de Ciencias Biologicas e da Saude,
      Universidade Tiradentes, Aracaju, SE 49000-000. malonepinheiro@hotmail.com
FAU - de Brito, Ana Maria Guedes
AU  - de Brito AM
FAU - Jeraldo, Veronica de Lourdes Sierpe
AU  - Jeraldo Vde L
FAU - Pinheiro, Kariny Souza
AU  - Pinheiro KS
LA  - por
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - Aspectos eticos em uma disputa de mercado entre laboratorios clinicos e um plano 
      de saude: relato de caso.
PL  - Brazil
TA  - Cien Saude Colet
JT  - Ciencia & saude coletiva
JID - 9713483
SB  - IM
MH  - *Bioethical Issues
MH  - Brazil
MH  - *Dissent and Disputes
MH  - Humans
MH  - *Insurance, Health
MH  - Laboratories/*ethics
MH  - Marketing of Health Services/*ethics
MH  - Private Sector
EDAT- 2011/04/29 06:00
MHDA- 2011/08/04 06:00
CRDT- 2011/04/20 06:00
PHST- 2008/01/02 00:00 [received]
PHST- 2008/03/03 00:00 [accepted]
PHST- 2011/04/20 06:00 [entrez]
PHST- 2011/04/29 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
AID - S1413-81232011000700003 [pii]
AID - 10.1590/s1413-81232011000700003 [doi]
PST - ppublish
SO  - Cien Saude Colet. 2011;16 Suppl 1:731-4. doi: 10.1590/s1413-81232011000700003.


PMID- 21501431
OWN - NLM
STAT- MEDLINE
DCOM- 20110624
LR  - 20220318
IS  - 1471-2458 (Electronic)
IS  - 1471-2458 (Linking)
VI  - 11 Suppl 3
DP  - 2011 Apr 13
TI  - Protective efficacy of malaria case management and intermittent preventive
      treatment for preventing malaria mortality in children: a systematic review for
      the Lives Saved Tool.
PG  - S14
LID - 10.1186/1471-2458-11-S3-S14 [doi]
AB  - BACKGROUND: The Lives Saved Tool (LiST) model was developed to estimate the
      impact of the scale-up of child survival interventions on child mortality. New
      advances in antimalarials have improved their efficacy of treating uncomplicated 
      and severe malaria. Artemisinin-based combination therapies (ACTs) for
      uncomplicated Plasmodium falciparum malaria and parenteral or rectal artemisinin 
      or quinine for severe malaria syndromes have been shown to be very effective for 
      the treatment of malaria in children. These interventions are now being
      considered for inclusion in the LiST model. However, for obvious ethical reasons,
      their protective efficacy (PE) compared to placebo is unknown and their impact on
      reducing malaria-attributable mortality has not been quantified. METHODS: We
      performed systematic literature reviews of published studies in P. falciparum
      endemic settings to determine the protective efficacy (PE) of ACT treatment
      against malaria deaths among children with uncomplicated malaria, as well as the 
      PE of effective case management including parenteral quinine against malaria
      deaths among all hospitalized children. As no randomized placebo-controlled
      trials of malaria treatment have been conducted, we used multiple data sources to
      ascertain estimates of PE, including a previously performed Delphi estimate for
      treatment of uncomplicated malaria. RESULTS: Based on multiple data sources, we
      estimate the PE of ACT treatment of uncomplicated P. falciparum malaria on
      reducing malaria mortality in children 1-23 months to be 99% (range: 94-100%),
      and in children 24-59 months to be 97% (range: 86-99%). We estimate the PE of
      treatment of severe P. falciparum malaria with effective case management
      including intravenous quinine on reducing malaria mortality in children 1-59
      months to be 82% (range: 63-94%) compared to no treatment. CONCLUSIONS: This
      systematic review quantifies the PE of ACT used for treating uncomplicated
      malaria and effective case management including parenteral quinine for treating
      severe P. falciparum malaria for preventing malaria mortality in children <5.
      These data will be used in the Lives Saved Tool (LiST) model for estimating the
      impact of scaling-up these interventions against malaria. However, in order to
      estimate the reduction in child mortality due to scale-up of these interventions,
      it is imperative to develop standardized indicators to measure population
      coverage of these interventions.
FAU - Thwing, Julie
AU  - Thwing J
AD  - Malaria Branch, Malaria Branch, Center for Global Health, Centers for Disease
      Control and Prevention, Atlanta, GA, USA. jthwing@cdc.gov
FAU - Eisele, Thomas P
AU  - Eisele TP
FAU - Steketee, Richard W
AU  - Steketee RW
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20110413
PL  - England
TA  - BMC Public Health
JT  - BMC public health
JID - 100968562
RN  - 0 (Antimalarials)
RN  - 0 (Artemisinins)
RN  - 9RMU91N5K2 (artemisinin)
RN  - A7V27PHC7A (Quinine)
SB  - IM
MH  - Africa South of the Sahara/epidemiology
MH  - Antimalarials/*therapeutic use
MH  - Artemisinins/*therapeutic use
MH  - Case Management
MH  - Child
MH  - Child Mortality
MH  - Drug Therapy, Combination
MH  - Humans
MH  - Malaria, Falciparum/mortality/*prevention & control
MH  - Quinine/*therapeutic use
MH  - Treatment Outcome
PMC - PMC3231887
EDAT- 2011/04/29 06:00
MHDA- 2011/06/28 06:00
CRDT- 2011/04/20 06:00
PHST- 2011/04/20 06:00 [entrez]
PHST- 2011/04/29 06:00 [pubmed]
PHST- 2011/06/28 06:00 [medline]
AID - 1471-2458-11-S3-S14 [pii]
AID - 10.1186/1471-2458-11-S3-S14 [doi]
PST - epublish
SO  - BMC Public Health. 2011 Apr 13;11 Suppl 3:S14. doi: 10.1186/1471-2458-11-S3-S14.


PMID- 21522485
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1861-8863 (Electronic)
IS  - 1861-8863 (Linking)
VI  - 7
DP  - 2011 Apr 19
TI  - Over-, under- and misuse of pain treatment in Germany.
PG  - Doc03
LID - 10.3205/hta000094 [doi]
AB  - BACKGROUND: The HTA-report (Health Technology Assessment) deals with over- and
      undertreatment of pain therapy. Especially in Germany chronic pain is a common
      reason for the loss of working hours and early retirement. In addition to a
      reduction in quality of life for the affected persons, chronic pain is therefore 
      also an enormous economic burden for society. OBJECTIVES: Which diseases are in
      particular relevant regarding pain therapy?What is the social-medical care
      situation regarding pain facilities in Germany?What is the social-medical care
      situation in pain therapy when comparing on international level?Which effects,
      costs or cost-effects can be seen on the micro-, meso- and macro level with
      regard to pain therapy?Among which social-medical services in pain therapy is
      there is an over- or undertreatment with regard to the micro-, meso- and macro
      level?Which medical and organisational aspects that have an effect on the costs
      and/or cost-effectiveness have to be particularly taken into account with regard 
      to pain treatment/chronic pain?What is the influence of the individual patient's 
      needs (micro level) in different situations of pain (e. g. palliative situation) 
      on the meso- and macro level?Which social-medical and ethical aspects for an
      adequate treatment of chronic pain on each level have to be specially taken into 
      account?Is the consideration of these aspects appropriate to avoid over- or
      undertreatment?Are juridical questions included in every day care of chronic pain
      patients, mainly in palliative care?On which level can appropriate interventions 
      prevent over- or undertreatment? METHODS: A systematic literature research is
      done in 35 databases. In the HTA, reviews, epidemiological and clinical studies
      and economic evaluations are included which report about pain therapy and in
      particular palliative care in the years 2005 till 2010. RESULTS: 47 studies meet 
      the inclusion criteria. An undertreatment of acupuncture, over- and misuse with
      regard to opiate prescription and an overuse regarding unspecific chest pain and 
      chronic low back pain (LBP) can be observed. The results show the benefit and the
      cost-effectiveness of interdisciplinary as well as multi-professional approaches,
      multimodal pain therapy and cross-sectoral integrated medical care. Only rough
      values can be determined about the care situation regarding the supply of pain
      therapeutic and palliative medical facilities as the data are completely
      insufficient. DISCUSSION: Due to the broad research question the HTA-report
      contains inevitably different outcomes and study designs which partially differ
      qualitatively very strong from each other. In the field of palliative care
      hospices for in-patients and palliative wards as well as hospices for
      out-patients are becoming more and more important. Palliative care is a basic
      right of all terminally ill persons. CONCLUSION: Despite the relatively high
      number of studies in Germany the HTA-report shows a massive lack in health care
      research. Based on the studies a further expansion of out-patient pain and
      palliative care is recommended. Further training for all involved professional
      groups must be improved. An independent empirical analysis is necessary to
      determine over or undertreatment in pain care.
FAU - Dietl, Markus
AU  - Dietl M
AD  - GP Forschungsgruppe, Institut fur Grundlagen- und Programmforschung, Munchen,
      Deutschland.
FAU - Korczak, Dieter
AU  - Korczak D
LA  - eng
PT  - Journal Article
DEP - 20110419
PL  - Germany
TA  - GMS Health Technol Assess
JT  - GMS health technology assessment
JID - 101276045
PMC - PMC3080661
OTO - NOTNLM
OT  - EBM
OT  - HTA
OT  - HTA report
OT  - HTA-report
OT  - RCT
OT  - accident
OT  - analgesia
OT  - back pain
OT  - biomedical technology assessment
OT  - blinded
OT  - blinding
OT  - care
OT  - chronic
OT  - chronic pain
OT  - clinical study
OT  - clinical trial
OT  - controlled clinical study
OT  - controlled clinical trial
OT  - controlled clinical trials as topic
OT  - cost analysis
OT  - cost control
OT  - cost effectiveness
OT  - cost reduction
OT  - cost-benefit analyses
OT  - cost-benefit analysis
OT  - cost-cutting
OT  - cost-effectiveness
OT  - costs
OT  - costs and cost analysis
OT  - cross over; crossover
OT  - cross-over
OT  - cross-over studies
OT  - cross-over trials
OT  - decision making
OT  - delivery of health care
OT  - diagnosis
OT  - doctor's note
OT  - double blind
OT  - double-blind
OT  - double-blind method
OT  - doubleblind
OT  - early retirement
OT  - economic aspect
OT  - economics
OT  - economics, medical
OT  - effectiveness
OT  - efficacy
OT  - efficiency
OT  - ethics
OT  - evaluation studies as topic
OT  - evidence based medicine
OT  - evidence-based medicine
OT  - headache; health
OT  - health care
OT  - health care costs
OT  - health economic studies
OT  - health economics
OT  - health policy
OT  - health technology assessment
OT  - healthcare needs
OT  - hospice
OT  - humans
OT  - integrated care
OT  - ischialgia
OT  - judgment
OT  - juricical
OT  - lack of work
OT  - life qualities
OT  - low back pain
OT  - lumbar pain
OT  - medical assessment
OT  - medical care
OT  - medical costs
OT  - medical evaluation
OT  - meta analysis
OT  - meta-analysis
OT  - methods
OT  - migraine
OT  - misuse
OT  - models, economic
OT  - multicenter
OT  - multicenter trial
OT  - multicentre
OT  - multimodal supply
OT  - neck pain
OT  - overuse
OT  - pain
OT  - pain care
OT  - pain clinic
OT  - pain clinics
OT  - pain disorder
OT  - pain management
OT  - pain measurement
OT  - pain patient
OT  - pain reduction
OT  - pain situation
OT  - pain therapy
OT  - palliative
OT  - palliative care
OT  - palliative medicine
OT  - palliative therapy
OT  - palliative treatment
OT  - palliative treatments
OT  - peer review
OT  - pharmaeconomics
OT  - placebo
OT  - placebo effect
OT  - placebos
OT  - prevention
OT  - program effectiveness
OT  - prospective studies
OT  - psychotherapy
OT  - quality of life
OT  - random
OT  - random allocation
OT  - randomisation
OT  - randomised clinical study
OT  - randomised clinical trial
OT  - randomised controlled study
OT  - randomised controlled trial
OT  - randomised study
OT  - randomised trial
OT  - randomization
OT  - randomized clinical study
OT  - randomized clinical trial
OT  - randomized controlled study
OT  - randomized controlled trial
OT  - randomized study
OT  - randomized trial
OT  - rehabilitation
OT  - report
OT  - research article
OT  - research-article
OT  - review
OT  - review literature
OT  - rights
OT  - risk assessment
OT  - sensitivity
OT  - shoulder pain
OT  - sick certificate
OT  - sick note
OT  - sickness costs
OT  - single blind
OT  - single blind method
OT  - single-blind
OT  - singleblind
OT  - social economic factors
OT  - socioeconomic factors
OT  - socioeconomics
OT  - somatoform disorders
OT  - specifity
OT  - spinal column
OT  - spondylosis
OT  - stoppage
OT  - supply shortage
OT  - systematic review
OT  - technical report
OT  - technology
OT  - technology assessment
OT  - technology assessment, biomedical
OT  - technology evaluation
OT  - technology, medical
OT  - therapy
OT  - thoracic spine
OT  - thoracic vertebral column
OT  - treatment
OT  - trial, cross-over
OT  - trial, crossover
OT  - triple blind
OT  - triple-blind
OT  - tripleblind
OT  - underuse
OT  - validation studies
OT  - vertebral column
EDAT- 2011/04/28 06:00
MHDA- 2011/04/28 06:01
CRDT- 2011/04/28 06:00
PHST- 2011/04/28 06:00 [entrez]
PHST- 2011/04/28 06:00 [pubmed]
PHST- 2011/04/28 06:01 [medline]
AID - 10.3205/hta000094 [doi]
PST - epublish
SO  - GMS Health Technol Assess. 2011 Apr 19;7:Doc03. doi: 10.3205/hta000094.


PMID- 21521883
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20151119
IS  - 1097-6817 (Electronic)
IS  - 0194-5998 (Linking)
VI  - 145
IP  - 2
DP  - 2011 Aug
TI  - Clinical equipoise in sleep surgery: investigating clinical trial targets.
PG  - 347-53
LID - 10.1177/0194599811406053 [doi]
AB  - OBJECTIVE: Surgical approaches for alleviating snoring and/or obstructive sleep
      apnea (OSA) have been questioned because of a lack of evidence from high-quality 
      randomized controlled trials (RCTs). An ethical requirement for RCTs is that they
      must test questions where community equipoise (ie, uncertainty) exists as to the 
      correct treatment. We aimed to measure perceived importance, community equipoise,
      and willingness to enroll patients in 5 potential trial targets among members of 
      the Australian Society for Otolaryngology Head and Neck Surgery (ASOHNS). STUDY
      DESIGN, SETTING, AND SUBJECTS: All ASOHNS members were surveyed using a
      multistage mail, email, Internet, and phone-based questionnaire. METHODS:
      Equipoise was measured for each of the scenarios using a bidirectional linear
      scale comparing 2 treatments. Responses were categorized into 1 of 3 groups: (A) 
      preferred treatment 1, (B) completely undecided, and (C) preferred treatment 2.
      The resulting proportions are called equipoise ratios: A:B:C. Using tick boxes,
      the authors queried the general clinical importance and willingness to enroll
      patients for all scenarios. RESULTS: A total of 167 of 313 surgeons responded
      (53.4%). Three of the 5 trial scenarios exhibited evidence of community
      equipoise, but 2 scenarios, radiofrequency ablation plus
      uvulopalatopharyngoplasty (UPPP) versus UPPP alone and upper-airway
      reconstruction versus mandibular advancement splint (MAS), did not have strong
      support for enrolling patients. Informal feedback indicates one of these may be
      feasible in a smaller number of specifically trained surgeons. CONCLUSION: We
      suggest 2 potential RCT targets: septoplasty and turbinate reduction versus
      conservative measures for snoring and airway reconstruction versus MAS for OSA,
      where importance, clinical equipoise, and willingness all exist.
FAU - Field, Clarice J
AU  - Field CJ
AD  - Australasian Sleep Trials Network and National Health and Medical Research
      Council Centre for Integrated Research and Understanding of Sleep, Sydney Medical
      School, University of Sydney, Sydney, Australia.
FAU - Robinson, Sam
AU  - Robinson S
FAU - Mackay, Stuart
AU  - Mackay S
FAU - Harrison, James D
AU  - Harrison JD
FAU - Marshall, Nathaniel S
AU  - Marshall NS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110426
PL  - England
TA  - Otolaryngol Head Neck Surg
JT  - Otolaryngology--head and neck surgery : official journal of American Academy of
      Otolaryngology-Head and Neck Surgery
JID - 8508176
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Otorhinolaryngologic Surgical Procedures/*ethics/methods
MH  - Patient Selection/ethics
MH  - Randomized Controlled Trials as Topic/*ethics/methods
MH  - Reconstructive Surgical Procedures/*ethics/methods
MH  - Sleep Wake Disorders/*surgery
MH  - Surveys and Questionnaires
MH  - *Therapeutic Equipoise
EDAT- 2011/04/28 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/04/28 06:00
PHST- 2011/04/28 06:00 [entrez]
PHST- 2011/04/28 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 0194599811406053 [pii]
AID - 10.1177/0194599811406053 [doi]
PST - ppublish
SO  - Otolaryngol Head Neck Surg. 2011 Aug;145(2):347-53. doi:
      10.1177/0194599811406053. Epub 2011 Apr 26.


PMID- 21521807
OWN - NLM
STAT- MEDLINE
DCOM- 20140204
LR  - 20220409
IS  - 1545-1097 (Print)
IS  - 1545-1097 (Linking)
VI  - 11
IP  - 2
DP  - 2012 Mar-Apr
TI  - Assessment of stigma and discrimination experienced by people living with HIV and
      AIDS receiving care/treatment in University of Ilorin Teaching Hospital (UITH),
      Ilorin, Nigeria.
PG  - 121-7
LID - 10.1177/1545109711399443 [doi]
AB  - The research was designed to assess the stigma and discrimination faced by People
      living with HIV and AIDS (PLWHA) that are receiving treatment in UITH, Ilorin.
      The study was a descriptive cross-sectional survey conducted on three hundred
      (300) people living with HIV and AIDS receiving care at the antiretroviral
      therapy (ART) clinics within University of Ilorin Teaching Hospital (which was
      the only ART site in Kwara State as at then). A quantitative method through the
      use of interviewer administered questionnaire was used for data collection. This 
      study was a cross-sectional descriptive study design. All the patients who came
      to the clinic and met the selection criteria were recruited until the desired
      sample size was reached. Data were analyzed by EPI-INFO 2005 software package.
      The mean age of the respondents was 39 years (SD = 9.32), and their age ranged
      between 19 and 65 years. About two thirds (64.7%) of the respondents were
      females, 62.7% were married, and 62.9% were from monogamous family settings.
      Slightly less than half (47.3%) of the respondents were not informed before they 
      were tested for HIV, majority (63.3%) were not counseled before the test, but
      only 11% did not receive posttest counseling. One quarter of the respondents had 
      experienced stigmatization/discrimination. Various forms of
      stigmatization/discrimination experienced by the respondents include blame for
      being responsible for their HIV status, various name callings, telling them that 
      they are no more useful to anybody, violation of confidentiality, social
      isolation, restriction of their participation in family/religious activities,
      rejection by their spouses/families, dismissal from place of work, isolating them
      from other patients, and denying them care at health centers. It is therefore
      recommended that government at all levels should develop and implement programs
      to educate health care providers about HIV and AIDS, ethics, and treatment and
      care; educate the general population on HIV and AIDS, put in place policies that 
      will reduce/stop HIV-related stigma and discrimination at all levels of the
      society, educate PLWHA on their right to live and work without discrimination,
      and also ensure full community participation in HIV control programs.
FAU - Owolabi, Rotimi S
AU  - Owolabi RS
AD  - 1HIV Unit, Department of Medicine, University of Abuja Teaching Hospital,
      Gwagwalada, Abuja, Nigeria.
FAU - Araoye, Margaret O
AU  - Araoye MO
FAU - Osagbemi, Gordon K
AU  - Osagbemi GK
FAU - Odeigah, Louis
AU  - Odeigah L
FAU - Ogundiran, Adeniyi
AU  - Ogundiran A
FAU - Hussain, Nurudeen A
AU  - Hussain NA
LA  - eng
PT  - Journal Article
DEP - 20110426
PL  - United States
TA  - J Int Assoc Physicians AIDS Care (Chic)
JT  - Journal of the International Association of Physicians in AIDS Care (Chicago,
      Ill. : 2002)
JID - 101185740
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/drug therapy/*psychology
MH  - Adult
MH  - Aged
MH  - Anti-HIV Agents/therapeutic use
MH  - Cross-Sectional Studies
MH  - Family Relations
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nigeria
MH  - *Prejudice
MH  - Refusal to Treat
MH  - Social Isolation
MH  - *Social Stigma
MH  - Surveys and Questionnaires
MH  - Unemployment
MH  - Young Adult
EDAT- 2011/04/28 06:00
MHDA- 2014/02/05 06:00
CRDT- 2011/04/28 06:00
PHST- 2011/04/28 06:00 [entrez]
PHST- 2011/04/28 06:00 [pubmed]
PHST- 2014/02/05 06:00 [medline]
AID - 1545109711399443 [pii]
AID - 10.1177/1545109711399443 [doi]
PST - ppublish
SO  - J Int Assoc Physicians AIDS Care (Chic). 2012 Mar-Apr;11(2):121-7. doi:
      10.1177/1545109711399443. Epub 2011 Apr 26.


PMID- 21521429
OWN - NLM
STAT- MEDLINE
DCOM- 20110907
LR  - 20211020
IS  - 1369-7625 (Electronic)
IS  - 1369-6513 (Linking)
VI  - 14
IP  - 2
DP  - 2011 Jun
TI  - Final responsibility for treatment choice: the proper role of medical doctors?
PG  - 201-9
LID - 10.1111/j.1369-7625.2011.00673.x [doi]
AB  - AIMS: To analyse whether the traditional allocation of decision-making
      responsibility is still justifiable. And, if not to analyse the strength of
      claims made by other health care professions and by patients. BACKGROUND:
      Traditionally doctors have been responsible for choices of treatment, both in
      terms of deciding and in terms of taking responsibility for the decisions. But
      modern health care work often takes place in teams involving health care
      professionals from different professions as well as the patient. In such teams it
      may not be obvious who should be responsible for treatment choice. METHODS:
      Philosophical analysis of epistemic, ethical and organizational arguments,
      including analysis of the historical origins of these arguments. RESULTS: The
      epistemic, ethical and organizational arguments for maintaining a primary
      decision making role for doctors are not sound. Other health care professionals
      can, in some circumstances make stronger and more justified claims. The arguments
      against allocation decision making authority to patients are also invalid or
      unsound in many circumstances. CONCLUSION: There are many situations in which
      final responsibility for treatment choice should rest with health care
      professionals who are not doctors and with patients.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Holm, Soren
AU  - Holm S
AD  - Centre for Social Ethics and Policy, School of Law Manchester, University of
      Manchester, Manchester, UK. soren.holm@manchester.ac.uk
LA  - eng
PT  - Comment
PT  - Journal Article
DEP - 20110427
PL  - England
TA  - Health Expect
JT  - Health expectations : an international journal of public participation in health 
      care and health policy
JID - 9815926
SB  - IM
CON - Health Expect. 2011 Jun;14(2):178-81. PMID: 21592263
MH  - *Decision Making
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Interdisciplinary Communication
MH  - Knowledge
MH  - Patient Education as Topic/methods
MH  - *Patient Participation
MH  - *Personal Autonomy
MH  - Physician's Role
MH  - *Physician-Patient Relations
MH  - Professional Autonomy
MH  - Social Change
MH  - Therapeutics/psychology
PMC - PMC5060566
EDAT- 2011/04/28 06:00
MHDA- 2011/09/08 06:00
CRDT- 2011/04/28 06:00
PHST- 2011/04/28 06:00 [entrez]
PHST- 2011/04/28 06:00 [pubmed]
PHST- 2011/09/08 06:00 [medline]
AID - 10.1111/j.1369-7625.2011.00673.x [doi]
PST - ppublish
SO  - Health Expect. 2011 Jun;14(2):201-9. doi: 10.1111/j.1369-7625.2011.00673.x. Epub 
      2011 Apr 27.


PMID- 21521353
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20110915
IS  - 1600-0528 (Electronic)
IS  - 0301-5661 (Linking)
VI  - 39
IP  - 5
DP  - 2011 Oct
TI  - Does oral infection cause cardiovascular disease? Oral and moral challenges.
PG  - 385-92
LID - 10.1111/j.1600-0528.2011.00617.x [doi]
AB  - OBJECTIVES: To address three questions: (i) does oral infection cause
      cardiovascular disease (CVD)? (ii) what kind of uncertainty is there in the
      relationship between oral infection and CVD? and (iii) how do we handle this
      uncertainty in practice: what should we do? METHODS: Conceptual analysis with
      basis in standard methods in philosophy of science and ethics. In particular, the
      study refers to theories of causality and uncertainty, as well as decision making
      theory. RESULTS: Whether oral infections cause CVD deeply depends on what we mean
      by causality. An investigation of the most prominent conceptions of causality
      suggests that it is far from obvious that oral infection causes CVD. A further
      analysis reveals that uncertainty occurs as risk, specific uncertainty,
      ignorance, and indeterminacy, which has implications for how we should handle
      oral infections. One option is to apply the precautionary principle. Another
      option is to attribute a cause owing to the strong social commitment to prevent
      CVD. CONCLUSIONS: A conceptual analysis shows that it is not obvious that oral
      infections cause CVD and that the question of causality does not only involve
      descriptive issues of science but also moral matters of society. Hence, whether
      oral infections cause CVD is an ethical and not only a scientific issue.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Hofmann, Bjorn M
AU  - Hofmann BM
AD  - Center for Medical Ethics, University of Oslo, Oslo, Norway.
LA  - eng
PT  - Journal Article
DEP - 20110427
PL  - Denmark
TA  - Community Dent Oral Epidemiol
JT  - Community dentistry and oral epidemiology
JID - 0410263
SB  - IM
MH  - Bioethics
MH  - Cardiovascular Diseases/*epidemiology
MH  - Causality
MH  - Clinical Trials as Topic
MH  - Decision Making
MH  - Disease Susceptibility
MH  - Humans
MH  - Morals
MH  - Periodontal Diseases/*epidemiology
MH  - Uncertainty
EDAT- 2011/04/28 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/04/28 06:00
PHST- 2011/04/28 06:00 [entrez]
PHST- 2011/04/28 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - 10.1111/j.1600-0528.2011.00617.x [doi]
PST - ppublish
SO  - Community Dent Oral Epidemiol. 2011 Oct;39(5):385-92. doi:
      10.1111/j.1600-0528.2011.00617.x. Epub 2011 Apr 27.


PMID- 21521251
OWN - NLM
STAT- MEDLINE
DCOM- 20121112
LR  - 20211020
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 26
IP  - 6
DP  - 2012 Jul
TI  - The need for systematic reviews of reasons.
PG  - 315-28
LID - 10.1111/j.1467-8519.2011.01858.x [doi]
AB  - There are many ethical decisions in the practice of health research and care, and
      in the creation of policy and guidelines. We argue that those charged with making
      such decisions need a new genre of review. The new genre is an application of the
      systematic review, which was developed over decades to inform medical
      decision-makers about what the totality of studies that investigate links between
      smoking and cancer, for example, implies about whether smoking causes cancer. We 
      argue that there is a need for similarly inclusive and rigorous reviews of
      reason-based bioethics, which uses reasoning to address ethical questions. After 
      presenting a brief history of the systematic review, we reject the only existing 
      model for writing a systematic review of reason-based bioethics, which holds that
      such a review should address an ethical question. We argue that such a systematic
      review may mislead decision-makers when a literature is incomplete, or when there
      are mutually incompatible but individually reasonable answers to the ethical
      question. Furthermore, such a review can be written without identifying all the
      reasons given when the ethical questions are discussed, their alleged
      implications for the ethical question, and the attitudes taken to the reasons.
      The reviews we propose address instead the empirical question of which reasons
      have been given when addressing a specified ethical question, and present such
      detailed information on the reasons. We argue that this information is likely to 
      improve decision-making, both directly and indirectly, and also the academic
      literature. We explain the limitations of our alternative model for systematic
      reviews.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Sofaer, Neema
AU  - Sofaer N
AD  - King's College London - Centre of Medical Law and Ethics, Strand London WC2R 2LS,
      UK. neema.sofaer@kcl.ac.uk
FAU - Strech, Daniel
AU  - Strech D
LA  - eng
GR  - 088360/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110427
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Decision Making/ethics
MH  - Delivery of Health Care/ethics
MH  - *Ethical Analysis
MH  - Human Experimentation/ethics
MH  - Humans
MH  - Models, Theoretical
MH  - Policy Making
MH  - *Review Literature as Topic
PMC - PMC3458717
EDAT- 2011/04/28 06:00
MHDA- 2012/11/13 06:00
CRDT- 2011/04/28 06:00
PHST- 2011/04/28 06:00 [entrez]
PHST- 2011/04/28 06:00 [pubmed]
PHST- 2012/11/13 06:00 [medline]
AID - 10.1111/j.1467-8519.2011.01858.x [doi]
PST - ppublish
SO  - Bioethics. 2012 Jul;26(6):315-28. doi: 10.1111/j.1467-8519.2011.01858.x. Epub
      2011 Apr 27.


PMID- 21520777
OWN - NLM
STAT- MEDLINE
DCOM- 20110701
LR  - 20110427
IS  - 1221-9118 (Print)
IS  - 1221-9118 (Linking)
VI  - 106
IP  - 1
DP  - 2011 Jan-Feb
TI  - Laparoscopic surgical education--the experience of the first surgical unit Iasi.
PG  - 67-76
AB  - The classic apprenticeship model for surgical training takes place into the
      operating theater under the strict coordination of a senior surgeon. During the
      time and especially after the introduction of minimally invasive techniques as
      gold standard treatment for many diseases, other methods were developed to
      successful fulfill the well known three stages of training: skill-based behavior,
      rule-based behavior and knowledge-based behavior. The skills needed for minimally
      invasive surgery aren't easily obtained using classical apprenticeship model due 
      to ethical, medico-legal and economic considerations. In this way several types
      of simulators have been developed. Nowadays simulators are worldwide accepted for
      laparoscopic surgical training and provide formative feedback which allows an
      improvement of the performances of the young surgeons. The simulators currently
      used allow assimilating only skill based behavior and rule-based behavior.
      However, the training using animal models as well as new virtual reality
      simulators and augmented reality offer the possibility to achieve knowledge-based
      behavior. However it isn't a worldwide accepted laparoscopic training curriculum.
      We present our experience with different types of simulators and teaching methods
      used along the time in our surgical unit. We also performed a review of the
      literature data.
FAU - Tarcoveanu, E
AU  - Tarcoveanu E
AD  - First Surgical Unit, St. Spiridon Hospital, Research Center for Open and
      Laparoscopic Surgery Iasi, Romania. etarco@iasi.mednet.ro
FAU - Moldovanu, R
AU  - Moldovanu R
FAU - Bradea, C
AU  - Bradea C
FAU - Dimofte, G
AU  - Dimofte G
FAU - Lupascu, C
AU  - Lupascu C
FAU - Georgescu, St
AU  - Georgescu S
FAU - Andronic, D
AU  - Andronic D
FAU - Lotz, J C
AU  - Lotz JC
FAU - Vlad, N
AU  - Vlad N
FAU - Vasilescu, A
AU  - Vasilescu A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Romania
TA  - Chirurgia (Bucur)
JT  - Chirurgia (Bucharest, Romania : 1990)
JID - 9213031
SB  - IM
MH  - Animals
MH  - Clinical Competence
MH  - *Computer Simulation
MH  - Curriculum
MH  - *Education, Medical, Continuing/methods
MH  - *Education, Medical, Graduate/methods
MH  - Evidence-Based Medicine
MH  - General Surgery/*education
MH  - Humans
MH  - Laparoscopes
MH  - Laparoscopy/*education
MH  - User-Computer Interface
EDAT- 2011/04/28 06:00
MHDA- 2011/07/02 06:00
CRDT- 2011/04/28 06:00
PHST- 2011/04/28 06:00 [entrez]
PHST- 2011/04/28 06:00 [pubmed]
PHST- 2011/07/02 06:00 [medline]
PST - ppublish
SO  - Chirurgia (Bucur). 2011 Jan-Feb;106(1):67-76.


PMID- 21520219
OWN - NLM
STAT- MEDLINE
DCOM- 20111007
LR  - 20131121
IS  - 1097-4547 (Electronic)
IS  - 0360-4012 (Linking)
VI  - 89
IP  - 8
DP  - 2011 Aug
TI  - Reversal of chlorpyrifos neurobehavioral teratogenicity in mice by allographic
      transplantation of adult subventricular zone-derived neural stem cells.
PG  - 1185-93
LID - 10.1002/jnr.22631 [doi]
AB  - Neurobehavioral teratogenicity can be reversed with transplantation of neural
      stem cells. However, the usefulness of this therapy would be greatly enhanced by 
      employing adult stem cells. In pursuit of this this goal, we developed a model
      that uses subventricular zone (SVZ) cells. HS/Ibg mice were exposed prenatally to
      chlorpyrifos on gestational days 9-18 (3 mg/kg/day, SC) in order to induce
      deficits in their performance in the Morris water maze test. Both the control and
      the exposed offspring were transplanted with SVZ cells (or vehicle) on postnatal 
      day 35; this actually represents an allogenic transplantation, because the HS/Ibg
      strain is a heterogeneous stock. The transplanted cells were later observed in
      the host brain by DiI tracing, and their initial differentiation to cholinergic
      neurons and astrocytes was ascertained. On postnatal day 80, animals that had
      been exposed prenatally to chlorpyrifos displayed impaired Morris water maze
      performance, requiring more time to reach the platform. Transplantation of adult 
      SVZ-derived neural stem cells (NSC) reversed the deficits. Applying autologous
      transplantation provides an important demonstration that the methodological
      obstacles of immunological rejection and the ethical concerns related to using
      embryonic stem cells may be successfully bypassed in developing stem cell
      therapies for neurodevelopmental disorders.
CI  - Copyright (c) 2011 Wiley-Liss, Inc.
FAU - Turgeman, Gadi
AU  - Turgeman G
AD  - Department of Molecular Biology, Ariel University Center of Samaria, Ariel,
      Israel.
FAU - Pinkas, Adi
AU  - Pinkas A
FAU - Slotkin, Theodore A
AU  - Slotkin TA
FAU - Tfilin, Matanel
AU  - Tfilin M
FAU - Langford, Rachel
AU  - Langford R
FAU - Yanai, Joseph
AU  - Yanai J
LA  - eng
GR  - ES014258/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110421
PL  - United States
TA  - J Neurosci Res
JT  - Journal of neuroscience research
JID - 7600111
RN  - 0 (Teratogens)
RN  - JCS58I644W (Chlorpyrifos)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/drug effects/physiology
MH  - Cerebral Ventricles/cytology
MH  - Chlorpyrifos/*toxicity
MH  - Female
MH  - Maze Learning/*drug effects/physiology
MH  - Mice
MH  - Neural Stem Cells/*transplantation
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*therapy
MH  - Teratogens/*toxicity
MH  - Transplantation, Homologous
EDAT- 2011/04/27 06:00
MHDA- 2011/10/08 06:00
CRDT- 2011/04/27 06:00
PHST- 2010/10/21 00:00 [received]
PHST- 2010/12/07 00:00 [revised]
PHST- 2011/01/27 00:00 [accepted]
PHST- 2011/04/27 06:00 [entrez]
PHST- 2011/04/27 06:00 [pubmed]
PHST- 2011/10/08 06:00 [medline]
AID - 10.1002/jnr.22631 [doi]
PST - ppublish
SO  - J Neurosci Res. 2011 Aug;89(8):1185-93. doi: 10.1002/jnr.22631. Epub 2011 Apr 21.


PMID- 21519726
OWN - NLM
STAT- MEDLINE
DCOM- 20110901
LR  - 20220408
IS  - 1699-5198 (Electronic)
IS  - 0212-1611 (Linking)
VI  - 26
IP  - 1
DP  - 2011 Jan-Feb
TI  - The reduction of the metabolyc syndrome in Navarra-Spain (RESMENA-S) study: a
      multidisciplinary strategy based on chrononutrition and nutritional education,
      together with dietetic and psychological control.
PG  - 16-26
LID - S0212-16112011000100002 [pii]
AB  - INTRODUCTION: The high prevalence of metabolic syndrome (MS) in Spain requires
      additional efforts for prevention and treatment. OBJECTIVE: The study RESMENA-S
      aims to improve clinical criteria and biomarkers associated with MS though an
      integral therapy approach. METHODS: The study is a randomized prospective
      parallel design in which is expected to participate a total of 100 individuals.
      The RESMENA-S group (n = 50) is a personalized weight loss (30% energy
      restriction) diet, with a macronutrient distribution (carbohydrate / fat /
      protein) of 40/30/30, high meal frequency (7 / day), low glycemic index/load and 
      high antioxidant capacity as well as a high adherence to the Mediterranean diet. 
      The control group (n = 50) is assigned to a diet with the same energy restriction
      and based on the American Heart Association pattern. Both experimental groups are
      under dietary and psychological control during 8 weeks. Likewise, for an
      additional period of 16 weeks of self-control, is expected that volunteers will
      follow the same pattern but with no dietary advice. RESULTS: Anthropometrical
      data and body composition determinations as well as blood and urine samples are
      being collected at the beginning and end of each phase. This project is
      registered at www.clinicaltrials.gov with the number NCT01087086 and count with
      the Research Ethics Committee of the University of Navarra approval (065/2009).
      CONCLUSIONS: Intervention trials to promote the adoption of dietary patterns and 
      healthy lifestyle are of great importance to identify the outcomes and
      nutritional mechanisms that might explain the link between obesity, metabolic
      syndrome and associated complications.
FAU - Zulet, M A
AU  - Zulet MA
AD  - Department of Nutrition, Food Sciences, Physiology & Toxicology, University of
      Navarra, Pamplona, Spain.
FAU - Bondia-Pons, I
AU  - Bondia-Pons I
FAU - Abete, I
AU  - Abete I
FAU - de la Iglesia, R
AU  - de la Iglesia R
FAU - Lopez-Legarrea, P
AU  - Lopez-Legarrea P
FAU - Forga, L
AU  - Forga L
FAU - Navas-Carretero, S
AU  - Navas-Carretero S
FAU - Martinez, J A
AU  - Martinez JA
LA  - eng
SI  - ClinicalTrials.gov/NCT01087086
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - Spain
TA  - Nutr Hosp
JT  - Nutricion hospitalaria
JID - 9100365
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - Biomarkers
MH  - Body Composition
MH  - Caloric Restriction
MH  - Counseling
MH  - *Diet
MH  - Diet, Mediterranean
MH  - Female
MH  - *Health Education
MH  - Humans
MH  - Life Style
MH  - Male
MH  - Metabolic Syndrome/epidemiology/*prevention & control/psychology
MH  - *Nutritional Physiological Phenomena
MH  - Patient Care Team
MH  - Prospective Studies
MH  - Research Design
MH  - Spain/epidemiology
MH  - Weight Loss
EDAT- 2011/04/27 06:00
MHDA- 2011/09/02 06:00
CRDT- 2011/04/27 06:00
PHST- 2010/10/07 00:00 [received]
PHST- 2010/10/22 00:00 [accepted]
PHST- 2011/04/27 06:00 [entrez]
PHST- 2011/04/27 06:00 [pubmed]
PHST- 2011/09/02 06:00 [medline]
AID - S0212-16112011000100002 [pii]
PST - ppublish
SO  - Nutr Hosp. 2011 Jan-Feb;26(1):16-26.


PMID- 21519421
OWN - NLM
STAT- MEDLINE
DCOM- 20110812
LR  - 20211020
IS  - 1553-6467 (Electronic)
IS  - 0002-9459 (Linking)
VI  - 75
IP  - 2
DP  - 2011 Mar 10
TI  - Pharmacogenomics training using an instructional software system.
PG  - 32
AB  - OBJECTIVES: To implement an elective course in pharmacogenomics designed to teach
      pharmacy students about the fundamentals of pharmacogenomics and the anticipated 
      changes it will bring to the profession. DESIGN: The 8 sessions of the course
      covered the basics of pharmacogenomics, genomic biotechnology, implementation of 
      pharmacogenetics in pharmacy, information security and privacy, ethical issues
      related to the use of genomic data, pharmacoepidemiology, and use and promotion
      of GeneScription, a software program designed to mimic the professional pharmacy 
      environment. ASSESSMENT: Student grades were based on completion of a patient
      education pamphlet, a 2-page paper on pharmacogenomics, and precourse and
      postcourse survey instruments. In the postcourse survey, all students strongly
      agreed that genomic data could be used to determine the optimal dose of a drug
      and genomic data for metabolizing enzymes could be stored in a safe place.
      Students also were more willing to submit deoxyribonucleic acid (DNA) data for
      genetic profiling and better understood how DNA analysis is performed after
      completing the course. CONCLUSIONS: An elective course in pharmacogenomics
      equipped pharmacy students with the basic knowledge necessary to make clinical
      decisions based on pharmacogenomic data and to teach other healthcare
      professionals and patients about pharmacogenomics. For personalized medicine to
      become a reality, all pharmacists and pharmacy students must learn this knowledge
      and these skills.
FAU - Springer, John A
AU  - Springer JA
AD  - Department of Computer and Information Technology, Purdue University.
FAU - Iannotti, Nicholas V
AU  - Iannotti NV
FAU - Kane, Michael D
AU  - Kane MD
FAU - Haynes, Kevin
AU  - Haynes K
FAU - Sprague, Jon E
AU  - Sprague JE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Pharm Educ
JT  - American journal of pharmaceutical education
JID - 0372650
SB  - IM
MH  - *Computer-Assisted Instruction
MH  - Curriculum
MH  - Education, Pharmacy/*methods
MH  - Educational Measurement
MH  - Humans
MH  - Pharmacists/organization & administration
MH  - Pharmacogenetics/*education/methods
MH  - Precision Medicine/methods
MH  - Professional Role
MH  - Software
MH  - Students, Pharmacy
PMC - PMC3073107
OTO - NOTNLM
OT  - drug safety
OT  - instructional software
OT  - personalized medicine
OT  - pharmacogenomics
EDAT- 2011/04/27 06:00
MHDA- 2011/08/13 06:00
CRDT- 2011/04/27 06:00
PHST- 2010/08/25 00:00 [received]
PHST- 2010/11/15 00:00 [accepted]
PHST- 2011/04/27 06:00 [entrez]
PHST- 2011/04/27 06:00 [pubmed]
PHST- 2011/08/13 06:00 [medline]
AID - 10.5688/ajpe75232 [doi]
PST - ppublish
SO  - Am J Pharm Educ. 2011 Mar 10;75(2):32. doi: 10.5688/ajpe75232.


PMID- 21518377
OWN - NLM
STAT- MEDLINE
DCOM- 20120423
LR  - 20111215
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 26
IP  - 1
DP  - 2012 Jan
TI  - Responsibilities in elderly care: Mr Powell's narrative of duty and relations.
PG  - 22-31
LID - 10.1111/j.1467-8519.2011.01898.x [doi]
AB  - In Western countries a considerable number of older people move to a residential 
      home when their health declines. Institutionalization often results in increased 
      dependence, inactivity and loss of identity or self-worth (dignity). This raises 
      the moral question as to how older, institutionalized people can remain
      autonomous as far as continuing to live in line with their own values is
      concerned. Following Walker's meta-ethical framework on the assignment of
      responsibilities, we suggest that instead of directing all older people towards
      more autonomy in terms of independence, professional caregivers should listen to 
      the life narrative of older people and attempt to find out how their personal
      identity, relations and values in life can be continued in the new setting. If
      mutual normative expectations between caregivers and older people are not
      carefully negotiated, it creates tension. This tension is illustrated by the
      narrative of Mr Powell, a retired successful public servant now living in a
      residential home. The narrative describes his current life, his need for help,
      his independent frame of mind, and his encounters with institutional and
      professional policies. Mr Powell sees himself as a man who has always cared for
      himself and others, and who still feels that he has to fulfil certain duties in
      life. Mr Powell's story shows that he is not always understood well by caregivers
      who respond from a one-sided view of autonomy as independence. This leads to
      misunderstanding and an underestimation of his need to be noticed and involved in
      the residential community.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Abma, Tineke
AU  - Abma T
AD  - Department of Medical Humanities, VU University Medical Center, Amsterdam
      Vughterstede, The Netherlands. t.abma@vumc.nl
FAU - Bruijn, Anne
AU  - Bruijn A
FAU - Kardol, Tinie
AU  - Kardol T
FAU - Schols, Jos
AU  - Schols J
FAU - Widdershoven, Guy
AU  - Widdershoven G
LA  - eng
PT  - Journal Article
DEP - 20110426
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Activities of Daily Living
MH  - Aged, 80 and over
MH  - *Homes for the Aged
MH  - Humans
MH  - *Interpersonal Relations
MH  - Male
MH  - *Personal Autonomy
MH  - *Professional-Patient Relations
EDAT- 2011/04/27 06:00
MHDA- 2012/04/24 06:00
CRDT- 2011/04/27 06:00
PHST- 2011/04/27 06:00 [entrez]
PHST- 2011/04/27 06:00 [pubmed]
PHST- 2012/04/24 06:00 [medline]
AID - 10.1111/j.1467-8519.2011.01898.x [doi]
PST - ppublish
SO  - Bioethics. 2012 Jan;26(1):22-31. doi: 10.1111/j.1467-8519.2011.01898.x. Epub 2011
      Apr 26.


PMID- 21518376
OWN - NLM
STAT- MEDLINE
DCOM- 20130529
LR  - 20121015
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 26
IP  - 9
DP  - 2012 Nov
TI  - Human enhancement and sexual dimorphism.
PG  - 464-75
LID - 10.1111/j.1467-8519.2011.01884.x [doi]
AB  - I argue that the existence of sexual dimorphism poses a profound challenge to
      those philosophers who wish to deny the moral significance of the idea of 'normal
      human capacities' in debates about the ethics of human enhancement. The
      biological sex of a child will make a much greater difference to their life
      prospects than many of the genetic variations that the philosophical and
      bioethical literature has previously been concerned with. It seems, then, that
      bioethicists should have something to say about the choice between a male and a
      female embryo. Either, 1) parents have reason to choose boys over girls; (2)
      parents have reason to choose girls over boys; or, (3) parents have neither
      reason to choose girls over boys nor reason to choose boys over girls. Embracing 
      either of the first two alternatives has strongly counterintuitive--and arguably 
      morally repugnant--consequences. To motivate the third option we must either make
      reference to the idea of 'normal human capacities' or argue that parents should
      consider the interests of society when thinking about what sort of children they 
      should bring into the world - an implication that should be extremely
      controversial in debates about the 'new eugenics'. I conclude, then, that the
      idea of 'normal human capacities' is properly crucial to reasoning about the
      ethics of shaping future persons.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Sparrow, Rob
AU  - Sparrow R
AD  - Monash University, Centre for Human Bioethics, Clayton, Victoria, Australia.
      robert.sparrow@arts.monash.edu.au
LA  - eng
PT  - Journal Article
DEP - 20110426
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - *Attitude to Health
MH  - Female
MH  - Genetic Enhancement/*ethics
MH  - Humans
MH  - Male
MH  - Moral Obligations
MH  - Parents
MH  - Preimplantation Diagnosis/ethics
MH  - *Sex Characteristics
MH  - Sex Preselection/*ethics
EDAT- 2011/04/27 06:00
MHDA- 2013/05/31 06:00
CRDT- 2011/04/27 06:00
PHST- 2011/04/27 06:00 [entrez]
PHST- 2011/04/27 06:00 [pubmed]
PHST- 2013/05/31 06:00 [medline]
AID - 10.1111/j.1467-8519.2011.01884.x [doi]
PST - ppublish
SO  - Bioethics. 2012 Nov;26(9):464-75. doi: 10.1111/j.1467-8519.2011.01884.x. Epub
      2011 Apr 26.


PMID- 21518322
OWN - NLM
STAT- MEDLINE
DCOM- 20110816
LR  - 20220409
IS  - 1756-185X (Electronic)
IS  - 1756-1841 (Linking)
VI  - 14
IP  - 2
DP  - 2011 May
TI  - Mesenchymal stem cell therapy for knee osteoarthritis. Preliminary report of four
      patients.
PG  - 211-5
LID - 10.1111/j.1756-185X.2011.01599.x [doi]
AB  - BACKGROUND: Osteoarthritis (OA) is a cartilage degenerative process, involving
      the immune system, producing local inflammatory reactions, with production of
      pro-inflammatory cytokines and metalloproteinases. No treatment is still
      available to improve or reverse the process. Stem cell therapy opened new
      horizons for treatment of many incurable diseases. Mesenchymal stem cells (MSCs) 
      due to their multi-lineage potential, immunosuppressive activities, limited
      immunogenicity and relative ease of growth in culture, have attracted attentions 
      for clinical use. AIM: The aim of this study was to examine whether MSC
      transplantation could reverse the OA process in the knee joint. The project was
      approved by the Tehran University of Medical Sciences Research Committee and
      Ethical Committee. PATIENTS AND METHODS: Four patients with knee osteoarthritis
      were selected for the study. They were aged 55, 57, 65 and 54 years, and had
      moderate to severe knee OA. After their signed written consent, 30 mL of bone
      marrow were taken and cultured for MSC growth. After having enough MSCs in
      culture (4-5 weeks) and taking in consideration all safety measures, cells were
      injected in one knee of each patient. RESULTS: The walking time for the pain to
      appear improved for three patients and remained unchanged for one. The number of 
      stairs they could climb and the pain on visual analog scale improved for all of
      them. On physical examination, the improvement was mainly for crepitus. It was
      minor for the improvement of the range of motion. CONCLUSION: Results were
      encouraging, but not excellent. Improvement of the technique may improve the
      results.
CI  - (c) 2011 The Authors. International Journal of Rheumatic Diseases (c) 2011 Asia
      Pacific League of Associations for Rheumatology and Blackwell Publishing Asia Pty
      Ltd.
FAU - Davatchi, Fereydoun
AU  - Davatchi F
AD  - Rheumatology Research Center, Tehran University of Medical Sciences, Shariati
      Hospital, Kargar Avenue, Tehran, Iran. fddh@davatchi.net
FAU - Abdollahi, Bahar Sadeghi
AU  - Abdollahi BS
FAU - Mohyeddin, Mandana
AU  - Mohyeddin M
FAU - Shahram, Farhad
AU  - Shahram F
FAU - Nikbin, Behrooz
AU  - Nikbin B
LA  - eng
SI  - ClinicalTrials.gov/NCT00550524
PT  - Clinical Trial
PT  - Journal Article
DEP - 20110304
PL  - England
TA  - Int J Rheum Dis
JT  - International journal of rheumatic diseases
JID - 101474930
SB  - IM
MH  - Aged
MH  - Biomechanical Phenomena
MH  - Cells, Cultured
MH  - Humans
MH  - Iran
MH  - Knee Joint/physiopathology/*surgery
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Middle Aged
MH  - Osteoarthritis, Knee/complications/physiopathology/*surgery
MH  - Pain/etiology/prevention & control
MH  - Pain Measurement
MH  - Pilot Projects
MH  - Range of Motion, Articular
MH  - Recovery of Function
MH  - Severity of Illness Index
MH  - Time Factors
MH  - Treatment Outcome
MH  - Walking
EDAT- 2011/04/27 06:00
MHDA- 2011/08/17 06:00
CRDT- 2011/04/27 06:00
PHST- 2011/04/27 06:00 [entrez]
PHST- 2011/04/27 06:00 [pubmed]
PHST- 2011/08/17 06:00 [medline]
AID - 10.1111/j.1756-185X.2011.01599.x [doi]
PST - ppublish
SO  - Int J Rheum Dis. 2011 May;14(2):211-5. doi: 10.1111/j.1756-185X.2011.01599.x.
      Epub 2011 Mar 4.


PMID- 21517937
OWN - NLM
STAT- MEDLINE
DCOM- 20111027
LR  - 20110718
IS  - 1365-2648 (Electronic)
IS  - 0309-2402 (Linking)
VI  - 67
IP  - 8
DP  - 2011 Aug
TI  - Group sequential and adaptive designs: a novel, promising tool for nursing
      research.
PG  - 1824-33
LID - 10.1111/j.1365-2648.2011.05651.x [doi]
AB  - BACKGROUND: In the standard approach to designing clinical trials in nursing
      research, the primary endpoint and test statistic to be used for the primary
      analysis are specified before trial initiation. The false positive error rate for
      the null hypothesis and statistical power to detect the targeted size of
      treatment effect are also specified. The main purpose of this paper is to
      introduce the usage of monitoring procedures on emerging data during the course
      of the trial, such as the group sequential and adaptive designs, to the nursing
      science study setting. METHOD: The article briefly describes the bases which
      group sequential and adaptive designs rely on as well as their statistical
      properties and give some practical considerations to ease orientation in both
      respects. The different approaches to sample size estimation are applied to a
      non-inferiority trial on the effect of Skin-to-Skin contact after caesarean birth
      on infant temperature. RESULTS: Group sequential designs enable interim
      monitoring while maintaining the integrity of the standard approach. By contrast,
      adaptive monitoring procedures, seek to provide the flexibility to modify the
      prespecified design features during the course of the trial at the expense of
      statistical efficiency. Clinically meaningful effect size different than
      originally thought and initial budget limitations are the situations where the
      flexibility of adaptive designs may offset their loss of efficiency. DISCUSSION: 
      Interim analyses in nursing clinical trials are an important tool developed to
      balance ethical and financial advantages of coming to conclusions of efficacy and
      safety before the planned end of the study against the risk of an incorrect
      conclusion.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Baldi, Ileana
AU  - Baldi I
AD  - Researcher Unit of Cancer Epidemiology, CPO Piemonte and University of Torino,
      Torino, Italy.
FAU - Gouchon, Silvia Maria
AU  - Gouchon SM
FAU - Di Giulio, Paola
AU  - Di Giulio P
FAU - Buja, Alessandra
AU  - Buja A
FAU - Gregori, Dario
AU  - Gregori D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110426
PL  - England
TA  - J Adv Nurs
JT  - Journal of advanced nursing
JID - 7609811
SB  - IM
MH  - Body Temperature/physiology
MH  - Breast Feeding
MH  - Cesarean Section
MH  - Clinical Protocols
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Italy
MH  - Mother-Child Relations
MH  - *Nursing Methodology Research
MH  - Perinatal Care/*methods
MH  - Postoperative Period
MH  - Pregnancy
MH  - Randomized Controlled Trials as Topic/*methods/statistics & numerical data
MH  - Research Design
MH  - Skin
MH  - Statistics as Topic/*methods
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2011/04/27 06:00
MHDA- 2011/10/28 06:00
CRDT- 2011/04/27 06:00
PHST- 2011/04/27 06:00 [entrez]
PHST- 2011/04/27 06:00 [pubmed]
PHST- 2011/10/28 06:00 [medline]
AID - 10.1111/j.1365-2648.2011.05651.x [doi]
PST - ppublish
SO  - J Adv Nurs. 2011 Aug;67(8):1824-33. doi: 10.1111/j.1365-2648.2011.05651.x. Epub
      2011 Apr 26.


PMID- 21517686
OWN - NLM
STAT- MEDLINE
DCOM- 20110822
LR  - 20110426
IS  - 1466-187X (Electronic)
IS  - 0142-159X (Linking)
VI  - 33
IP  - 5
DP  - 2011
TI  - Making sense of ethics and law in the medical curriculum.
PG  - 384-7
LID - 10.3109/0142159X.2011.550966 [doi]
AB  - The moment a patient comes into the treatment room, the medical professional is
      placed in both an ethical and a legal context. The task for medical teachers is
      to equip students for this clinical reality in a way that makes sense both to the
      learners and to the variety of medical educators in the school, all of whom will 
      have their own interpretations of the nature of this subject area. Ethics and law
      in the medical curriculum (Dowie and Martin 2011), aims to provide an
      understanding of how ethics and law can be incorporated into the curriculum in a 
      structured, coherent, and logical manner. It is essential that we begin with a
      vision of the primary purpose of our course, and clarify the overall domain of
      learning to which it relates. Rather than presenting students with a miscellany
      of ethico-legal topics, their learning can be reinforced by constructing a frame 
      around the key emphases in law and ethics. A professional ethics frame is
      proposed, highlighting the everyday, theory-based, habits, intentions,
      consequences and society elements of this approach. The course also has to be
      mediated within the wider curriculum, and this benefits from a coherent and
      communicated course scheme that is directly meaningful within the educational
      setting of the medical school. Finally, within the Guide, examples of humanistic 
      schemes are presented that centre on aspects of boundary in patient care, themed 
      around body, person and community of practice.
FAU - Dowie, A L
AU  - Dowie AL
AD  - General Practice and Primary Care University of Glasgow, Scotland, UK.
      al.dowie@glasgow.ac.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - Med Teach
JT  - Medical teacher
JID - 7909593
SB  - IM
MH  - Curriculum
MH  - Education, Medical/*organization & administration
MH  - Ethics, Medical/*education
MH  - Humans
MH  - *Legislation, Medical
EDAT- 2011/04/27 06:00
MHDA- 2011/08/23 06:00
CRDT- 2011/04/27 06:00
PHST- 2011/04/27 06:00 [entrez]
PHST- 2011/04/27 06:00 [pubmed]
PHST- 2011/08/23 06:00 [medline]
AID - 10.3109/0142159X.2011.550966 [doi]
PST - ppublish
SO  - Med Teach. 2011;33(5):384-7. doi: 10.3109/0142159X.2011.550966.


PMID- 21517681
OWN - NLM
STAT- MEDLINE
DCOM- 20110822
LR  - 20110426
IS  - 1466-187X (Electronic)
IS  - 0142-159X (Linking)
VI  - 33
IP  - 5
DP  - 2011
TI  - The teaching of medical ethics.
PG  - 349-50
LID - 10.3109/0142159X.2011.571728 [doi]
FAU - Campbell, Alastair V
AU  - Campbell AV
AD  - Centre for Biomedical Ethics, Yong Loo Lin School of Medicine, National
      University of Singapore, Singapore. medavc@nus.edu.sg
LA  - eng
PT  - Introductory Journal Article
PL  - England
TA  - Med Teach
JT  - Medical teacher
JID - 7909593
SB  - IM
MH  - *Education, Medical
MH  - Ethics, Medical/*education
MH  - Humans
EDAT- 2011/04/27 06:00
MHDA- 2011/08/23 06:00
CRDT- 2011/04/27 06:00
PHST- 2011/04/27 06:00 [entrez]
PHST- 2011/04/27 06:00 [pubmed]
PHST- 2011/08/23 06:00 [medline]
AID - 10.3109/0142159X.2011.571728 [doi]
PST - ppublish
SO  - Med Teach. 2011;33(5):349-50. doi: 10.3109/0142159X.2011.571728.


PMID- 21517680
OWN - NLM
STAT- MEDLINE
DCOM- 20110822
LR  - 20220409
IS  - 1466-187X (Electronic)
IS  - 0142-159X (Linking)
VI  - 33
IP  - 5
DP  - 2011
TI  - Reflective ability and moral reasoning in final year medical students: a
      semi-qualitative cohort study.
PG  - e281-9
LID - 10.3109/0142159X.2011.558531 [doi]
AB  - BACKGROUND: Moral reasoning and reflective ability are important concepts in
      medical education. To date, the association between reflective ability and moral 
      reasoning in medical students has not been measured. AIM: This study tested the
      hypotheses that, amongst final year medical students, (1) moral reasoning and
      reflective ability improve over time and (2) positive change in reflective
      ability favourably influences moral reasoning. METHODS: With Institutional
      Ethical approval, 56 medical students (of a class of 110) participated fully both
      at the beginning and end of the final academic year. Reflective ability and moral
      reasoning were assessed at each time using Sobral's reflection-in-learning scale 
      (RLS), Boenink's overall reflection score and by employing Kohlberg's schema for 
      moral reasoning. RESULTS: The most important findings were that (1) Students'
      level of reflective ability scores related to medicine decreased significantly
      over the course of the year, (2) students demonstrated a predominantly
      conventional level of moral reasoning at both the beginning and end of the year, 
      (3) moral reasoning scores tended to decrease over the course of the year and (4)
      RLS is a strong predictor of change in moral reasoning over time. CONCLUSION:
      This study confirms the usefulness of Sobral's RLS and BOR score for evaluating
      moral development in the context of medical education. This study further
      documents regression and levelling in the moral reasoning of final year medical
      students and a decrease in reflective ability applied in the medical context.
      Further studies are required to determine factors that would favourably influence
      reflective ability and moral reasoning among final year medical students.
FAU - Chalmers, Patricia
AU  - Chalmers P
AD  - Department of Anaesthesia and Intensive Care Medicine, University College Cork,
      Wilton, Ireland. P.Chalmers@ucc.ie
FAU - Dunngalvin, Audrey
AU  - Dunngalvin A
FAU - Shorten, George
AU  - Shorten G
LA  - eng
PT  - Journal Article
PL  - England
TA  - Med Teach
JT  - Medical teacher
JID - 7909593
SB  - IM
MH  - Adult
MH  - Cohort Studies
MH  - Ethics, Medical
MH  - Female
MH  - Humans
MH  - *Learning
MH  - Male
MH  - *Morals
MH  - Observer Variation
MH  - Qualitative Research
MH  - Students, Medical/*psychology
MH  - Time Factors
EDAT- 2011/04/27 06:00
MHDA- 2011/08/23 06:00
CRDT- 2011/04/27 06:00
PHST- 2011/04/27 06:00 [entrez]
PHST- 2011/04/27 06:00 [pubmed]
PHST- 2011/08/23 06:00 [medline]
AID - 10.3109/0142159X.2011.558531 [doi]
PST - ppublish
SO  - Med Teach. 2011;33(5):e281-9. doi: 10.3109/0142159X.2011.558531.


PMID- 21516371
OWN - NLM
STAT- MEDLINE
DCOM- 20120919
LR  - 20181201
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 18
IP  - 2
DP  - 2012 Jun
TI  - Climate change: evidence of human causes and arguments for emissions reduction.
PG  - 393-410
LID - 10.1007/s11948-011-9270-6 [doi]
AB  - In a recent editorial, Raymond Spier expresses skepticism over claims that
      climate change is driven by human actions and that humanity should act to avoid
      climate change. This paper responds to this skepticism as part of a broader
      review of the science and ethics of climate change. While much remains uncertain 
      about the climate, research indicates that observed temperature increases are
      human-driven. Although opinions vary regarding what should be done, prominent
      arguments against action are based on dubious factual and ethical positions.
      Thus, the skepticisms in the recent editorial are unwarranted. This does not
      diminish the general merits of skeptical intellectual inquiry.
FAU - Baum, Seth D
AU  - Baum SD
AD  - Department of Geography, Pennsylvania State University, University Park, PA, USA.
      sbaum@psu.edu
FAU - Haqq-Misra, Jacob D
AU  - Haqq-Misra JD
FAU - Karmosky, Chris
AU  - Karmosky C
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20110423
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
CON - Sci Eng Ethics. 2008 Mar;14(1):1-2. PMID: 18273694
MH  - *Climate
MH  - *Greenhouse Effect
EDAT- 2011/04/26 06:00
MHDA- 2012/09/20 06:00
CRDT- 2011/04/26 06:00
PHST- 2009/04/02 00:00 [received]
PHST- 2011/02/03 00:00 [accepted]
PHST- 2011/04/26 06:00 [entrez]
PHST- 2011/04/26 06:00 [pubmed]
PHST- 2012/09/20 06:00 [medline]
AID - 10.1007/s11948-011-9270-6 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2012 Jun;18(2):393-410. doi: 10.1007/s11948-011-9270-6. Epub 2011
      Apr 23.


PMID- 21515929
OWN - NLM
STAT- MEDLINE
DCOM- 20110705
LR  - 20110425
IS  - 1881-6096 (Print)
IS  - 1881-6096 (Linking)
VI  - 63
IP  - 5
DP  - 2011 May
TI  - [Development of a telephone survey system for patients with amyotrophic lateral
      sclerosis using the ALSFRS-R (Japanese version) and application of this system in
      a longitudinal multicenter study].
PG  - 491-6
AB  - To investigate the various clinical courses of patients with amyotrophic lateral 
      sclerosis (ALS), we developed a telephone survey system for determining the
      activities of daily living (ADL) status of patients with ALS. In this system,
      every 3 months, clinical research coordinators (CRCs) conducted a telephone
      survey using the flow charts of the revised Amyotrophic Lateral Sclerosis
      Functional Rating Scale (ALSFRS-R; Japanese version). To confirm the reliability 
      of the results of the telephone survey, we compared the scores of 37 ALS patients
      obtained in the telephone surveys (telephone scores) to the scores obtained
      during clinical examinations by neurologists (neurologists' scores). The mean
      (SD) age of the included patients was 62.6 (11.8) years. Eighteen patients
      answered the surveys themselves, whereas the primary caregivers of 19 patients
      answered the surveys for the patients. Before the study, we informed the CRCs of 
      the study plan, general knowledge of ALS, procedures of the telephone survey,
      ethical issues relevant to the study, and requisite considerations for ALS
      patients and caregivers. The intraclass correlation coefficient (ICC) between the
      telephone scores and the neurologists' scores in the 37 ALS patients was 0.97
      (95% confidence interval [CI], 0.94-0.98). The kappa statistics of 12 questions
      of the ALSFRS-R between the telephone scores and the neurologists' scores ranged 
      from 0.58 to 0.85. The ICC of the scores of the 18 cases in which the patients
      answered the telephone questions themselves was 0.96 (95% CI, 0.89-0.98). The ICC
      of the scores of the 19 cases in which the caregivers answered the telephone
      questions was 0.97 (95% CI, 0.92-0.99). These results showed a good reliability
      of the telephone survey, regardless of whether the patients themselves or the
      caregivers answered telephone questions. In 2006, a longitudinal multicenter
      study of Japanese ALS patients was initiated called the Japanese Consortium for
      Amyotrophic Lateral Sclerosis research (JaCALS). In the JaCALS, prospective
      clinical information was obtained using this telephone survey system. Of the 284 
      ALS patients who were registered at JaCALS over a year ago, 93% were followed up 
      and provided ALSFRS-R scores and information relevant to prognosis. We have
      established an efficient and reliable telephone survey system for studying the
      longitudinal clinical courses of patients with ALS.
FAU - Atsuta, Naoki
AU  - Atsuta N
AD  - Department of Neurology, Nagoya University Hospital, Showa-ku, Nagoya, Japan.
FAU - Watanabe, Hirohisa
AU  - Watanabe H
FAU - Ito, Mizuki
AU  - Ito M
FAU - Nakamura, Ryoichi
AU  - Nakamura R
FAU - Senda, Jo
AU  - Senda J
FAU - Kato, Shigenori
AU  - Kato S
FAU - Sobue, Gen
AU  - Sobue G
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Brain Nerve
JT  - Brain and nerve = Shinkei kenkyu no shinpo
JID - 101299709
SB  - IM
MH  - *Activities of Daily Living
MH  - Aged
MH  - Amyotrophic Lateral Sclerosis/*psychology
MH  - Cohort Studies
MH  - Female
MH  - Health Surveys/*methods
MH  - Humans
MH  - Interviews as Topic/*methods
MH  - Japan
MH  - Language
MH  - *Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - *Multicenter Studies as Topic
MH  - Prospective Studies
MH  - Reproducibility of Results
MH  - *Telephone
EDAT- 2011/04/26 06:00
MHDA- 2011/07/06 06:00
CRDT- 2011/04/26 06:00
PHST- 2011/04/26 06:00 [entrez]
PHST- 2011/04/26 06:00 [pubmed]
PHST- 2011/07/06 06:00 [medline]
AID - 1416100908 [pii]
PST - ppublish
SO  - Brain Nerve. 2011 May;63(5):491-6.


PMID- 21515876
OWN - NLM
STAT- MEDLINE
DCOM- 20120301
LR  - 20111019
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 11
DP  - 2011 Nov
TI  - Moral experience: a framework for bioethics research.
PG  - 658-62
LID - 10.1136/jme.2010.039008 [doi]
AB  - Theoretical and empirical research in bioethics frequently focuses on ethical
      dilemmas or problems. This paper draws on anthropological and phenomenological
      sources to develop an alternative framework for bioethical enquiry that allows
      examination of a broader range of how the moral is experienced in the everyday
      lives of individuals and groups. Our account of moral experience is subjective
      and hermeneutic. We define moral experience as "Encompassing a person's sense
      that values that he or she deem important are being realised or thwarted in
      everyday life. This includes a person's interpretations of a lived encounter, or 
      a set of lived encounters, that fall on spectrums of right-wrong, good-bad or
      just-unjust". In our conceptualisation, moral experience is not limited to
      situations that are heavily freighted with ethically-troubling ramifications or
      are sources of debate and disagreement. Important aspects of moral experience are
      played out in mundane and everyday settings. Moral experience provides a research
      framework, the scope of which extends beyond the evaluation of ethical dilemmas, 
      processes of moral justification and decision-making, and moral distress. This
      broad research focus is consistent with views expressed by commentators within
      and beyond bioethics who have called for deeper and more sustained attention in
      bioethics scholarship to a wider set of concerns, experiences and issues that
      better captures what is ethically at stake for individuals and communities. In
      this paper we present our conceptualisation of moral experience, articulate its
      epistemological and ontological foundations and discuss opportunities for
      empirical bioethics research using this framework.
FAU - Hunt, Matthew R
AU  - Hunt MR
AD  - Centre de Recherche en Ethique (CREUM), University of Montreal, C.P. 6128, succ. 
      Centre-ville, Montreal, QC H3C 3J7, Canada. 1matthew.hunt@gmail.com
FAU - Carnevale, Franco A
AU  - Carnevale FA
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110422
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Bioethics
MH  - Biomedical Research/*ethics/methods/standards
MH  - *Ethics, Medical
MH  - Humans
MH  - Morals
EDAT- 2011/04/26 06:00
MHDA- 2012/03/02 06:00
CRDT- 2011/04/26 06:00
PHST- 2011/04/26 06:00 [entrez]
PHST- 2011/04/26 06:00 [pubmed]
PHST- 2012/03/02 06:00 [medline]
AID - jme.2010.039008 [pii]
AID - 10.1136/jme.2010.039008 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Nov;37(11):658-62. doi: 10.1136/jme.2010.039008. Epub 2011 Apr
      22.


PMID- 21515001
OWN - NLM
STAT- MEDLINE
DCOM- 20120209
LR  - 20220321
IS  - 1879-0046 (Electronic)
IS  - 0376-8716 (Linking)
VI  - 118
IP  - 2-3
DP  - 2011 Nov 1
TI  - Potential role of safer injection facilities in reducing HIV and hepatitis C
      infections and overdose mortality in the United States.
PG  - 100-10
LID - 10.1016/j.drugalcdep.2011.03.006 [doi]
AB  - BACKGROUND: Safer injection facilities (SIFs) reduce risks associated with
      injecting drugs, particularly public injection and overdose mortality. They exist
      in many countries, but do not exist in the United States. We assessed several
      ethical, operational, and public health considerations for establishing SIFs in
      the United States. METHOD: We used the six-factor Kass framework (goals,
      effectiveness, concerns, minimization of concerns, fair implementation, and
      balancing of benefits and concerns), summarized needs of persons who inject drugs
      in the United States, and reviewed global evidence for SIFs. RESULTS: SIFs offer 
      a hygienic environment to inject drugs, provide sterile injection equipment at
      time of injection, and allow for safe disposal of used equipment. Injection of
      pre-obtained drugs, purchased by persons who inject drugs, happens in a facility 
      where trained personnel provide on-site counseling and referral to addiction
      treatment and health care and intervene in overdose emergency situations. SIFs
      provide positive health benefits (reducing transmission of HIV and viral
      hepatitis, bacterial infections, and overdose mortality) without evidence for
      negative health or social consequences. SIFs serve most-at-risk persons,
      including those who inject in public or inject frequently, and those who do not
      use other public health programs. It is critical to address legal, ethical, and
      local concerns, develop and implement relevant policies and procedures, and
      assess individual- and community-level needs and benefits of SIFs given local
      epidemiologic data. CONCLUSIONS: SIFs have the potential to reduce viral and
      bacterial infections and overdose mortality among those who engage in high-risk
      injection behaviors by offering unique public health services that are
      complementary to other interventions.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Semaan, Salaam
AU  - Semaan S
AD  - Emory University, Rollins School of Public Health, Department of Behavioral
      Sciences and Health Education, Grace Crum Rollins Building, 1518 Clifton Road,
      Atlanta, GA 30322, USA. ssemaan@emory.edu
FAU - Fleming, Paul
AU  - Fleming P
FAU - Worrell, Caitlin
AU  - Worrell C
FAU - Stolp, Haley
AU  - Stolp H
FAU - Baack, Brittney
AU  - Baack B
FAU - Miller, Meghan
AU  - Miller M
LA  - eng
PT  - Journal Article
DEP - 20110423
PL  - Ireland
TA  - Drug Alcohol Depend
JT  - Drug and alcohol dependence
JID - 7513587
SB  - IM
MH  - Drug Overdose/mortality/*prevention & control
MH  - HIV Infections/etiology/*prevention & control
MH  - *Harm Reduction
MH  - Hepatitis C/etiology/*prevention & control
MH  - Humans
MH  - Injections
MH  - *Public Health
MH  - Substance Abuse, Intravenous/*complications
MH  - United States
EDAT- 2011/04/26 06:00
MHDA- 2012/02/10 06:00
CRDT- 2011/04/26 06:00
PHST- 2011/01/03 00:00 [received]
PHST- 2011/03/08 00:00 [revised]
PHST- 2011/03/09 00:00 [accepted]
PHST- 2011/04/26 06:00 [entrez]
PHST- 2011/04/26 06:00 [pubmed]
PHST- 2012/02/10 06:00 [medline]
AID - S0376-8716(11)00132-3 [pii]
AID - 10.1016/j.drugalcdep.2011.03.006 [doi]
PST - ppublish
SO  - Drug Alcohol Depend. 2011 Nov 1;118(2-3):100-10. doi:
      10.1016/j.drugalcdep.2011.03.006. Epub 2011 Apr 23.


PMID- 21514986
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20110718
IS  - 1873-1570 (Electronic)
IS  - 0300-9572 (Linking)
VI  - 82
IP  - 8
DP  - 2011 Aug
TI  - Hands-off time during insertion of six airway devices during cardiopulmonary
      resuscitation: a randomised manikin trial.
PG  - 1060-3
LID - 10.1016/j.resuscitation.2011.03.027 [doi]
AB  - INTRODUCTION: Cardiopulmonary resuscitation (CPR) guidelines recommend limiting
      interruptions of chest compressions because prolonged hands-off (i.e.,
      non-compression) time compromises tissue perfusion. 2010 European Resuscitation
      Council guidelines suggest that chest compressions should be paused less than 10 
      s during airway device insertion. METHODS: With approval of the local ethics
      committee of the Medical University of Vienna and written informed consent, we
      recruited 40 voluntary emergency medical technicians, none of whom had advanced
      airway management experience. After a standardised audio-visual lecture and
      practical demonstration, technicians performed airway management with each six
      airway devices (endotracheal tube, Combitube, EasyTube, laryngeal tube, Laryngeal
      Mask Airway, and I-Gel) during on-going chest compressions in a randomised
      sequence on a Resusci Anne Advanced Simulator. Data were analysed using a
      mixed-effects model accounting for the repeated measurements and pair-wise
      comparisons among the airway devices. RESULTS: The hands-off time associated with
      airway management using an endotracheal tube (including all intubation attempts) 
      was 48 s (95% confidence interval: 43-53). The hands-off time for airway
      management using a laryngeal tube was 8.4 (3.4-16.4) s, Combitube 10.0 (4.9-15.1)
      s, EasyTube 11.4 (6.4-16.4) s, LMA 13.3 (8.2-18.3) s and for I-Gel 15.9
      (10.8-20.9) s. Hands-off time was significantly longer with the conventional
      endotracheal tube than with any of the other airway systems. Only a third of the 
      technicians successfully inserted an endotracheal tube whereas all of them
      successfully positioned each supraglottic device. CONCLUSION: Supraglottic
      devices appear to be a reasonable emergency airway management strategy, even for 
      inexperienced personnel.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Ruetzler, Kurt
AU  - Ruetzler K
AD  - Department of Cardiothoracic and Vascular Anesthesia and Intensive Care Medicine,
      Medical University of Vienna, Vienna, Austria.
FAU - Gruber, Christina
AU  - Gruber C
FAU - Nabecker, Sabine
AU  - Nabecker S
FAU - Wohlfarth, Philipp
AU  - Wohlfarth P
FAU - Priemayr, Anita
AU  - Priemayr A
FAU - Frass, Michael
AU  - Frass M
FAU - Kimberger, Oliver
AU  - Kimberger O
FAU - Sessler, Daniel I
AU  - Sessler DI
FAU - Roessler, Bernhard
AU  - Roessler B
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20110406
PL  - Ireland
TA  - Resuscitation
JT  - Resuscitation
JID - 0332173
SB  - IM
MH  - Adult
MH  - Airway Management/*standards
MH  - Cardiopulmonary Resuscitation/*standards
MH  - Emergency Medical Technicians/*education
MH  - Female
MH  - Humans
MH  - Intubation, Intratracheal/standards
MH  - Laryngeal Masks/standards
MH  - Male
MH  - *Manikins
MH  - Professional Competence
EDAT- 2011/04/26 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/04/26 06:00
PHST- 2011/03/06 00:00 [received]
PHST- 2011/03/17 00:00 [revised]
PHST- 2011/03/24 00:00 [accepted]
PHST- 2011/04/26 06:00 [entrez]
PHST- 2011/04/26 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0300-9572(11)00221-8 [pii]
AID - 10.1016/j.resuscitation.2011.03.027 [doi]
PST - ppublish
SO  - Resuscitation. 2011 Aug;82(8):1060-3. doi: 10.1016/j.resuscitation.2011.03.027.
      Epub 2011 Apr 6.


PMID- 21514914
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20110913
IS  - 1878-0539 (Electronic)
IS  - 1748-6815 (Linking)
VI  - 64
IP  - 10
DP  - 2011 Oct
TI  - Transplantation of a latissimus dorsi flap between identical twins.
PG  - 1366-9
LID - 10.1016/j.bjps.2011.03.002 [doi]
AB  - We present a case of composite tissue transplantation of a latissimus dorsi flap 
      between monozygotic twins. The recipient twin, a 19 year old male, suffered from 
      a complex spinal kyphoscoliosis for which he had undergone multiple previous
      operations over many years. Soft tissue breakdown on his back causing metalwork
      exposure had necessitated the removal of his most recent spinal rod. This in turn
      led to rapid severe deterioration of his spinal deformity and consequent critical
      impairment of lung function. Robust soft tissue cover was required urgently in
      order to allow the insertion of a new spinal rod. His previous surgeries and body
      habitus precluded an adequate autologous reconstruction. Instead, reconstruction 
      using composite tissue transplantation from his identical twin brother was
      successfully undertaken. We discuss the ethical, psychological and surgical
      issues involved in this case.
CI  - Copyright (c) 2011 British Association of Plastic, Reconstructive and Aesthetic
      Surgeons. Published by Elsevier Ltd. All rights reserved.
FAU - Banwell, M E
AU  - Banwell ME
AD  - Plastic Surgery Department, Norfolk & Norwich University Hospital, Colney Lane,
      Norwich, NR4 7UY, UK.
FAU - Clibbon, J J
AU  - Clibbon JJ
FAU - Sassoon, E M
AU  - Sassoon EM
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20110422
PL  - Netherlands
TA  - J Plast Reconstr Aesthet Surg
JT  - Journal of plastic, reconstructive & aesthetic surgery : JPRAS
JID - 101264239
SB  - IM
MH  - Back
MH  - Diseases in Twins/psychology/surgery
MH  - Humans
MH  - Male
MH  - Muscle, Skeletal/*transplantation
MH  - Spinal Curvatures/*surgery
MH  - *Surgical Flaps
MH  - Tissue Transplantation/ethics/*psychology
MH  - Twins, Monozygotic
MH  - Wounds and Injuries/*surgery
MH  - Young Adult
EDAT- 2011/04/26 06:00
MHDA- 2011/11/09 06:00
CRDT- 2011/04/26 06:00
PHST- 2010/11/04 00:00 [received]
PHST- 2011/02/24 00:00 [revised]
PHST- 2011/03/02 00:00 [accepted]
PHST- 2011/04/26 06:00 [entrez]
PHST- 2011/04/26 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - S1748-6815(11)00096-9 [pii]
AID - 10.1016/j.bjps.2011.03.002 [doi]
PST - ppublish
SO  - J Plast Reconstr Aesthet Surg. 2011 Oct;64(10):1366-9. doi:
      10.1016/j.bjps.2011.03.002. Epub 2011 Apr 22.


PMID- 21514876
OWN - NLM
STAT- MEDLINE
DCOM- 20111013
LR  - 20110607
IS  - 1769-6682 (Electronic)
IS  - 1297-9589 (Linking)
VI  - 39
IP  - 6
DP  - 2011 Jun
TI  - [Precariousness, DRG's and health planning: pilot study at the Lariboisiere
      hospital in Paris].
PG  - 351-7
LID - 10.1016/j.gyobfe.2011.02.018 [doi]
AB  - OBJECTIVES: This paper considers the specific administrative procedures set up by
      managers of public healthcare establishments and those responsible for health and
      welfare policies to care for low-income pregnant women for whom 100% of the
      "price per act" (T2A) is refunded. What are the limitations and what improvements
      can be suggested? PATIENTS AND METHOD: The results are based on an analysis of
      data from semi-structured interviews, legislation and documents. RESULTS: The
      State, health insurance systems, public health establishments, local authorities,
      charities and outpatient services are involved in handling low-income parturients
      in different services and different establishments, both locally and regionally. 
      A health and welfare policy comprising specific, coordinated actions and measures
      has been developed. The T2A "price per act" system may threaten its survival: the
      limited number of front-line facilities is often saturated and demand is
      increasing, treatment is often reduced to reactive management leading to unwanted
      readmissions, ethics are sometimes called into question and there is a risk of
      patient selection. DISCUSSION AND CONCLUSION: This pilot study provided some
      encouraging information but also indicated the limitations of the approach
      adopted. However, it was still of interest to see whether it was possible to use 
      this approach, which did not require considerable resources, to reveal useful
      markers. This appeared to be the case. Regional Health Agencies (ARS) and local
      authorities could support the system. Additional funding is needed.
CI  - Copyright (c) 2011. Published by Elsevier SAS.
FAU - Mainpin, C
AU  - Mainpin C
AD  - Module interprofessionnel de sante publique 2009, ecole des hautes etudes en
      sante publique EHESP, avenue du Professeur-Leon-Bernard, 35043 Rennes cedex,
      France.
FAU - Blond, C
AU  - Blond C
FAU - Bottin, F
AU  - Bottin F
FAU - Gezequel, B
AU  - Gezequel B
FAU - Guillemot, M
AU  - Guillemot M
FAU - Horvath, M
AU  - Horvath M
FAU - Muller, M
AU  - Muller M
FAU - Prat, V
AU  - Prat V
FAU - Morel, O
AU  - Morel O
FAU - Barranger, E
AU  - Barranger E
FAU - Brechat, P-H
AU  - Brechat PH
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Precarite, tarification a l'activite et planification sanitaire et sociale: etude
      pilote a l'hopital Lariboisiere de Paris.
DEP - 20110422
PL  - France
TA  - Gynecol Obstet Fertil
JT  - Gynecologie, obstetrique & fertilite
JID - 100936305
SB  - IM
MH  - Diagnosis-Related Groups/economics/ethics/legislation &
      jurisprudence/*organization & administration
MH  - Female
MH  - Health Planning/economics/ethics/legislation & jurisprudence/*organization &
      administration
MH  - Hospital Administration/*economics/ethics/legislation & jurisprudence
MH  - Humans
MH  - Paris
MH  - Patient Selection/ethics
MH  - Pilot Projects
MH  - Poverty/economics/ethics/legislation & jurisprudence
MH  - Pregnancy
EDAT- 2011/04/26 06:00
MHDA- 2011/10/14 06:00
CRDT- 2011/04/26 06:00
PHST- 2010/03/05 00:00 [received]
PHST- 2010/11/26 00:00 [accepted]
PHST- 2011/04/26 06:00 [entrez]
PHST- 2011/04/26 06:00 [pubmed]
PHST- 2011/10/14 06:00 [medline]
AID - S1297-9589(11)00078-6 [pii]
AID - 10.1016/j.gyobfe.2011.02.018 [doi]
PST - ppublish
SO  - Gynecol Obstet Fertil. 2011 Jun;39(6):351-7. doi: 10.1016/j.gyobfe.2011.02.018.
      Epub 2011 Apr 22.


PMID- 21514497
OWN - NLM
STAT- MEDLINE
DCOM- 20110818
LR  - 20110425
IS  - 1532-656X (Electronic)
IS  - 0891-5245 (Linking)
VI  - 25
IP  - 3
DP  - 2011 May-Jun
TI  - Sharing "moral space": Ethical caveats for the PNP hospitalist.
PG  - 198-202
LID - 10.1016/j.pedhc.2011.02.010 [doi]
FAU - Fernandes, Ashley K
AU  - Fernandes AK
AD  - Department of Community Health, Boonshoft School of Medicine, Wright State
      University, 3640 Colonel Glenn Hwy, Dayton, OH 45435, USA.
      ashley.fernandes@wright.edu
FAU - Onady, Gary M
AU  - Onady GM
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Pediatr Health Care
JT  - Journal of pediatric health care : official publication of National Association
      of Pediatric Nurse Associates & Practitioners
JID - 8709735
MH  - Acute Disease
MH  - Communication
MH  - Gastroenteritis/*therapy
MH  - Gastroenterology/*ethics
MH  - Hospitalists/*ethics
MH  - Humans
MH  - Infant
MH  - Interprofessional Relations
MH  - Nurse Practitioners/*ethics/psychology
MH  - Pediatrics/*ethics
EDAT- 2011/04/26 06:00
MHDA- 2011/08/19 06:00
CRDT- 2011/04/26 06:00
PHST- 2011/01/11 00:00 [received]
PHST- 2011/02/10 00:00 [revised]
PHST- 2011/02/16 00:00 [accepted]
PHST- 2011/04/26 06:00 [entrez]
PHST- 2011/04/26 06:00 [pubmed]
PHST- 2011/08/19 06:00 [medline]
AID - S0891-5245(11)00079-4 [pii]
AID - 10.1016/j.pedhc.2011.02.010 [doi]
PST - ppublish
SO  - J Pediatr Health Care. 2011 May-Jun;25(3):198-202. doi:
      10.1016/j.pedhc.2011.02.010.


PMID- 21513259
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20110425
IS  - 0160-7480 (Print)
IS  - 0160-7480 (Linking)
VI  - 41
IP  - 12
DP  - 2011 Mar 21
TI  - Foundation reformed. ACHE ethics code provides basis for meeting the challenge of
      transparency.
PG  - 22
FAU - Stacey, Rulon
AU  - Stacey R
AD  - Poudre Valley Health System, Fort Collins, Colo, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Mod Healthc
JT  - Modern healthcare
JID - 7801798
MH  - *Codes of Ethics
MH  - Health Facility Administrators/*ethics
MH  - Humans
MH  - *Societies
MH  - Truth Disclosure/*ethics
MH  - United States
EDAT- 2011/04/26 06:00
MHDA- 2011/06/03 06:00
CRDT- 2011/04/26 06:00
PHST- 2011/04/26 06:00 [entrez]
PHST- 2011/04/26 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
PST - ppublish
SO  - Mod Healthc. 2011 Mar 21;41(12):22.


PMID- 21512859
OWN - NLM
STAT- MEDLINE
DCOM- 20120209
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 17
IP  - 2
DP  - 2011 Jun
TI  - Responsible authorship in engineering fields: an overview of current ethical
      challenges.
PG  - 355-64
LID - 10.1007/s11948-011-9272-4 [doi]
AB  - The primary aim of this article is to identify ethical challenges relating to
      authorship in engineering fields. Professional organizations and journals do
      provide crucial guidance in this realm, but this cannot replace the need for
      frequent and diligent discussions in engineering research communities about what 
      constitutes appropriate authorship practice. Engineering researchers should seek 
      to identify and address issues such as who is entitled to be an author and
      whether publishing their research could potentially harm the public.
FAU - Borenstein, Jason
AU  - Borenstein J
AD  - School of Public Policy, Georgia Tech, 685 Cherry Street, Atlanta, GA 30332-0345,
      USA. borenstein@gatech.edu
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110422
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Authorship
MH  - Engineering/*ethics
MH  - *Ethics, Research
MH  - Humans
MH  - Periodicals as Topic/*ethics
MH  - Publishing/ethics
MH  - *Social Responsibility
EDAT- 2011/04/23 06:00
MHDA- 2012/02/10 06:00
CRDT- 2011/04/23 06:00
PHST- 2007/09/02 00:00 [received]
PHST- 2011/02/25 00:00 [accepted]
PHST- 2011/04/23 06:00 [entrez]
PHST- 2011/04/23 06:00 [pubmed]
PHST- 2012/02/10 06:00 [medline]
AID - 10.1007/s11948-011-9272-4 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2011 Jun;17(2):355-64. doi: 10.1007/s11948-011-9272-4. Epub 2011 
      Apr 22.


PMID- 21512808
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20211020
IS  - 1437-9813 (Electronic)
IS  - 0179-0358 (Linking)
VI  - 27
IP  - 6
DP  - 2011 Jun
TI  - Emerging ethical issues in pediatric surgery.
PG  - 555-62
LID - 10.1007/s00383-011-2907-3 [doi]
AB  - With the rapid pace of technological advancement and changing political, social, 
      and legal attitudes, physicians face new ethical dilemmas. For pediatric
      surgeons, these emerging issues affect our relationship with, and the care we
      provide, to our patients and their families. In this review, we explore issues
      related to professionalism in pediatric surgery practice, the value of apology,
      and the risks associated with sleep deprivation. Furthermore, we discuss how the 
      imperative of patient safety presents an opportunity for specialty-driven effort 
      to define standards for the surgical care of children and a responsible process
      for introducing surgical innovations. Finally, we remind pediatric surgeons of
      their ethical and professional duty to support clinical research, and advocate
      the acceptance of community equipoise as sufficient basis for enrolling children 
      in clinical trials.
FAU - Nwomeh, Benedict C
AU  - Nwomeh BC
AD  - Ohio State University College of Medicine, Nationwide Children's Hospital,
      Columbus, OH 43205, USA. nwomeh.1@osu.edu
FAU - Caniano, Donna A
AU  - Caniano DA
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110422
PL  - Germany
TA  - Pediatr Surg Int
JT  - Pediatric surgery international
JID - 8609169
SB  - IM
MH  - Child
MH  - Clinical Competence/*standards
MH  - *Ethics, Medical
MH  - General Surgery/*ethics
MH  - Humans
MH  - Pediatrics/*ethics
MH  - Surgical Procedures, Operative/*ethics
EDAT- 2011/04/23 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/04/23 06:00
PHST- 2011/04/04 00:00 [accepted]
PHST- 2011/04/23 06:00 [entrez]
PHST- 2011/04/23 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/s00383-011-2907-3 [doi]
PST - ppublish
SO  - Pediatr Surg Int. 2011 Jun;27(6):555-62. doi: 10.1007/s00383-011-2907-3. Epub
      2011 Apr 22.


PMID- 21512524
OWN - NLM
STAT- MEDLINE
DCOM- 20110621
LR  - 20110422
IS  - 1532-6535 (Electronic)
IS  - 0009-9236 (Linking)
VI  - 89
IP  - 5
DP  - 2011 May
TI  - The bioethics of iPS cell-based drug discovery.
PG  - 646-7
LID - 10.1038/clpt.2010.308 [doi]
AB  - The ability to generate human induced pluripotent stem (iPS) cells presents
      exciting prospects for drug discovery and the development of safer, more
      effective drugs. Given the enormous potential for iPS cell-based drug
      development, what ethical issues could possibly cloud this new biomedical
      horizon?
FAU - Hyun, I
AU  - Hyun I
AD  - Department of Bioethics, Case Western Reserve University, School of Medicine,
      Cleveland, Ohio, USA. insoo.hyun@case.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Pharmacol Ther
JT  - Clinical pharmacology and therapeutics
JID - 0372741
SB  - IM
MH  - *Bioethical Issues
MH  - Cell Differentiation/physiology
MH  - Drug Discovery/*ethics/trends
MH  - Humans
MH  - *Induced Pluripotent Stem Cells/cytology/transplantation
MH  - Moral Obligations
EDAT- 2011/04/23 06:00
MHDA- 2011/06/22 06:00
CRDT- 2011/04/23 06:00
PHST- 2011/04/23 06:00 [entrez]
PHST- 2011/04/23 06:00 [pubmed]
PHST- 2011/06/22 06:00 [medline]
AID - clpt2010308 [pii]
AID - 10.1038/clpt.2010.308 [doi]
PST - ppublish
SO  - Clin Pharmacol Ther. 2011 May;89(5):646-7. doi: 10.1038/clpt.2010.308.


PMID- 21511970
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20151119
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 8
DP  - 2011 Aug
TI  - Need for ethics support in healthcare institutions: views of Dutch board members 
      and ethics support staff.
PG  - 456-60
LID - 10.1136/jme.2010.040626 [doi]
AB  - OBJECTIVE: The purpose of this article is to investigate the need for ethics
      support in Dutch healthcare institutions in order to understand why ethics
      support is often not used in practice and which factors are relevant in this
      context. METHODS: This study had a mixed methods design integrating quantitative 
      and qualitative research methods. Two survey questionnaires, two focus groups and
      17 interviews were conducted among board members and ethics support staff in
      Dutch healthcare institutions. FINDINGS: Most respondents see a need for ethics
      support. This need is related to the complexity of contemporary healthcare, the
      contribution of ethics support to the core business of the organisation and to
      the surplus value of paying structural attention to ethical issues. The need for 
      ethics support is, however, not unconditional. Reasons for a lacking need
      include: aversion of innovations, negative associations with the notion of ethics
      support service, and organisational factors like resources and setting.
      CONCLUSION: There is a conditioned need for ethics support in Dutch healthcare
      institutions. The promotion of ethics support in healthcare can be fostered by
      focusing on formats which fit the needs of (practitioners in) healthcare
      institutions. The emphasis should be on creating a (culture of) dialogue about
      the complex situations which emerge daily in contemporary healthcare practice.
FAU - Dauwerse, Linda
AU  - Dauwerse L
AD  - Department of Medical Humanities, EMGO Institute for Health and Care Research, VU
      University Medical Center, Amsterdam, The Netherlands. l.dauwerse@vumc.nl
FAU - Abma, Tineke
AU  - Abma T
FAU - Molewijk, Bert
AU  - Molewijk B
FAU - Widdershoven, Guy
AU  - Widdershoven G
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20110421
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Decision Support Systems, Clinical/*ethics
MH  - Delivery of Health Care
MH  - Ethics Consultation/*organization & administration
MH  - *Ethics, Institutional/education
MH  - Evaluation Studies as Topic
MH  - Focus Groups
MH  - Health Planning Support
MH  - Humans
MH  - Interviews as Topic
MH  - Needs Assessment
MH  - Netherlands
MH  - Qualitative Research
MH  - Surveys and Questionnaires
EDAT- 2011/04/23 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/04/23 06:00
PHST- 2011/04/23 06:00 [entrez]
PHST- 2011/04/23 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - jme.2010.040626 [pii]
AID - 10.1136/jme.2010.040626 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Aug;37(8):456-60. doi: 10.1136/jme.2010.040626. Epub 2011 Apr 
      21.


PMID- 21511969
OWN - NLM
STAT- MEDLINE
DCOM- 20120103
LR  - 20110922
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 10
DP  - 2011 Oct
TI  - Reflecting on senior medical students' ethics reports at the University of
      Auckland.
PG  - 627-30
LID - 10.1136/jme.2011.042903 [doi]
AB  - In January 2010, fifth year medical students in the medical programme at the
      University of Auckland were asked to write a 1200-word report as part of their
      ethics assessment. The purpose of the report was to get students to reflect
      critically on the ethical dimension of a clinical case or situation they had been
      involved in during the past 2 years. Students were required to identify and
      discuss the salient ethical issues that arose as they saw them, and consider what
      they had personally learnt from the situation. The purpose of the following
      discussion is twofold: first, to outline some of the ethical issues raised by
      year five medical students in their ethics reports; and second, to reflect on
      what we, as educators and health professionals can learn from their experiences
      and insights.
FAU - Malpas, Phillipa J
AU  - Malpas PJ
AD  - Department of Psychological Medicine, The University of Auckland, Auckland 1142, 
      New Zealand. p.malpas@auckland.ac.nz
LA  - eng
PT  - Journal Article
DEP - 20110421
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Curriculum
MH  - Education, Medical, Undergraduate/*methods/standards
MH  - Educational Measurement/*methods/standards
MH  - Ethics, Medical/*education
MH  - Humans
MH  - New Zealand
MH  - Students, Medical/*psychology
EDAT- 2011/04/23 06:00
MHDA- 2012/01/04 06:00
CRDT- 2011/04/23 06:00
PHST- 2011/04/23 06:00 [entrez]
PHST- 2011/04/23 06:00 [pubmed]
PHST- 2012/01/04 06:00 [medline]
AID - jme.2011.042903 [pii]
AID - 10.1136/jme.2011.042903 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Oct;37(10):627-30. doi: 10.1136/jme.2011.042903. Epub 2011 Apr
      21.


PMID- 21511845
OWN - NLM
STAT- MEDLINE
DCOM- 20110824
LR  - 20151119
IS  - 1461-7471 (Electronic)
IS  - 1363-4615 (Linking)
VI  - 48
IP  - 1-2
DP  - 2011 Apr
TI  - ''What are you?'' A recurring question in a cross-cultural psychiatrist's life
      and career.
PG  - 37-52
LID - 10.1177/1363461510383178 [doi]
AB  - This article contributes to the Transcultural Psychiatry special issue of
      autobiographical articles on: ''The Personal and the Professional: Lives and
      Careers of Cultural Psychiatrists.'' The author describes influences and themes
      in her professional development as a cross-cultural psychiatrist and academic.
      Growing up as a part-Chinese, part-white child in rural Midwestern America
      resulted in frequently being asked: ''What are you?'' This abrupt, bald, but
      essential question eventually became a useful tool in the productive, repeated
      re-working of identity, values, and goals throughout her personal and
      professional life. Experiences of being an outsider, family histories, and early 
      observations of racism are linked to later interests in cross-cultural
      psychiatry, ethics, and the protection of vulnerable populations. She describes
      her research on cross-cultural measurement, depression, suicidality, domestic
      violence and violence in war. Issues of career advancement and internal conflict 
      are described for women academics who occupy three simultaneous, primary roles:
      academic, doctor and mother. The theme of ''crossing,'' as in ''cross-cultural,''
      indicates the effort and intention required to move between races, cultures,
      classes, intellectual disciplines, personal and professional identities, clinical
      and academic roles, and social roles allocated to men and women.
FAU - Hicks, Madelyn Hsiao-Rei
AU  - Hicks MH
AD  - Community Mental Health and Cultural Psychiatry, Health Service and Population
      Research Department, Institute of Psychiatry, King's College London, London, UK. 
      MJHHicks@aol.com
LA  - eng
PT  - Journal Article
PL  - England
TA  - Transcult Psychiatry
JT  - Transcultural psychiatry
JID - 9708119
SB  - IM
MH  - Asian Americans/*psychology
MH  - *Career Choice
MH  - Career Mobility
MH  - Cultural Diversity
MH  - Domestic Violence/ethnology/psychology
MH  - Ethnopsychology/education/*trends
MH  - Faculty, Medical
MH  - Forecasting
MH  - Gender Identity
MH  - Humans
MH  - Leadership
MH  - Mental Disorders/ethnology/psychology
MH  - Physician's Role/*psychology
MH  - Physicians, Women/psychology
MH  - Prejudice
MH  - Refugees/psychology
MH  - Research/trends
MH  - Risk Factors
MH  - Social Values
MH  - Suicide/ethnology/psychology
MH  - United States
MH  - Warfare
EDAT- 2011/04/23 06:00
MHDA- 2011/08/25 06:00
CRDT- 2011/04/23 06:00
PHST- 2011/04/23 06:00 [entrez]
PHST- 2011/04/23 06:00 [pubmed]
PHST- 2011/08/25 06:00 [medline]
AID - 48/1-2/37 [pii]
AID - 10.1177/1363461510383178 [doi]
PST - ppublish
SO  - Transcult Psychiatry. 2011 Apr;48(1-2):37-52. doi: 10.1177/1363461510383178.


PMID- 21511680
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20220316
IS  - 1940-1574 (Electronic)
IS  - 0003-3197 (Linking)
VI  - 62
IP  - 7
DP  - 2011 Oct
TI  - Methodological issues in the quantitative assessment of quality of life.
PG  - 517-9
LID - 10.1177/0003319711403735 [doi]
AB  - The term quality of life can be identified in Aristotle's classical writings of
      330 BC. In his Nichomachian ethics he recognises the multiple relationships
      between happiness, well-being, "eudemonia" and quality of life. Historically the 
      concept of quality of life has undergone various interpretations. It involves
      personal experience, perceptions and beliefs, attitudes concerning philosophical,
      cultural, spiritual, psychological, political, and financial aspects of everyday 
      living. Quality of life has been extensively used both as an outcome and an
      explanatory factor in relation to human health, in various clinical trials,
      epidemiologic studies and health interview surveys. Because of the variations in 
      the definition of quality of life, both in theory and in practice, there are also
      a wide range of procedures that are used to assess quality of life. In this paper
      several methodological issues regarding the tools used to evaluate quality of
      life is discussed. In summary, the use of components consisted of large number of
      classes, as well as the use of specific weights for each scale component, and the
      low-to-moderate inter-correlation level between the components, is evident from
      simulated and empirical studies.
FAU - Panagiotakos, Demosthenes B
AU  - Panagiotakos DB
FAU - Yfantopoulos, John N
AU  - Yfantopoulos JN
LA  - eng
PT  - Editorial
DEP - 20110420
PL  - United States
TA  - Angiology
JT  - Angiology
JID - 0203706
SB  - IM
MH  - *Health Status Indicators
MH  - Humans
MH  - *Quality of Life
MH  - Reproducibility of Results
MH  - Socioeconomic Factors
EDAT- 2011/04/23 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/04/23 06:00
PHST- 2011/04/23 06:00 [entrez]
PHST- 2011/04/23 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 0003319711403735 [pii]
AID - 10.1177/0003319711403735 [doi]
PST - ppublish
SO  - Angiology. 2011 Oct;62(7):517-9. doi: 10.1177/0003319711403735. Epub 2011 Apr 20.


PMID- 21511532
OWN - NLM
STAT- MEDLINE
DCOM- 20120117
LR  - 20190429
IS  - 1873-5223 (Electronic)
IS  - 1471-5953 (Linking)
VI  - 11
IP  - 6
DP  - 2011 Nov
TI  - Enhancing health students' understanding of generic research concepts using a
      web-based video resource.
PG  - 375-9
LID - 10.1016/j.nepr.2011.03.012 [doi]
AB  - This paper presents the development and evaluation of a set of innovative video
      resources aimed at enhancing health students' understanding and learning of
      generic research concepts. It is vital that health students achieve a solid
      foundation in research methods in order to support and inform evidence-based
      practice. Research concepts were identified through a stakeholder consultation
      with research methods teaching staff from a variety of health professions.
      Research concepts and processes included reliability, validity, statistical
      significance, descriptive statistics, qualitative and quantitative methods,
      sampling and population, research ethics and searching for and evaluating
      literature. Videos were produced, informed by a 3-component model, including:
      first, animated slides of concept definition, second, acted analogical scenarios 
      of concepts and third, interviews with staff regarding the application of the
      concepts in their own research. Workshop-style focus groups were conducted with
      27 students from midwifery, paramedicine and physiotherapy degree programmes.
      Overall, students perceived the resources as demystifying the topic of research
      methods through the clarification of definition and application of concepts and
      making sense of concepts through the analogical videos. Students evaluated the
      resources extremely positively in comparison with books and lectures and believed
      that the combination of audio and visual media benefited their learning.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Callaghan, Lynne
AU  - Callaghan L
AD  - Faculty of Health, University of Plymouth, Plymouth, UK.
      lcallaghan@plymouth.ac.uk
FAU - Lea, Susan J
AU  - Lea SJ
FAU - Mutton, Lauren
AU  - Mutton L
FAU - Whittlesea, Emma
AU  - Whittlesea E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110420
PL  - Scotland
TA  - Nurse Educ Pract
JT  - Nurse education in practice
JID - 101090848
SB  - IM
MH  - Attitude of Health Personnel
MH  - Education, Nursing/*methods
MH  - Female
MH  - Focus Groups
MH  - Humans
MH  - *Internet
MH  - Male
MH  - Nursing Education Research
MH  - Research/*education
MH  - Students, Nursing/*psychology
MH  - *Video Recording
EDAT- 2011/04/23 06:00
MHDA- 2012/01/18 06:00
CRDT- 2011/04/23 06:00
PHST- 2010/05/19 00:00 [received]
PHST- 2011/01/31 00:00 [revised]
PHST- 2011/03/13 00:00 [accepted]
PHST- 2011/04/23 06:00 [entrez]
PHST- 2011/04/23 06:00 [pubmed]
PHST- 2012/01/18 06:00 [medline]
AID - S1471-5953(11)00052-7 [pii]
AID - 10.1016/j.nepr.2011.03.012 [doi]
PST - ppublish
SO  - Nurse Educ Pract. 2011 Nov;11(6):375-9. doi: 10.1016/j.nepr.2011.03.012. Epub
      2011 Apr 20.


PMID- 21511295
OWN - NLM
STAT- MEDLINE
DCOM- 20110719
LR  - 20110512
IS  - 1527-3792 (Electronic)
IS  - 0022-5347 (Linking)
VI  - 185
IP  - 6
DP  - 2011 Jun
TI  - The portrayal of J. Marion Sims' controversial surgical legacy.
PG  - 2424-7
LID - 10.1016/j.juro.2011.01.077 [doi]
AB  - PURPOSE: In the mid 1800s Dr. J. Marion Sims reported the successful repair of
      vesicovaginal fistulas with a technique he developed by performing multiple
      operations on female slaves. A venerated physician in his time, the legacy of Dr.
      Sims is controversial and represents a significant chapter in the mistreatment of
      African-Americans by the medical establishment. This review compares the modern
      debate surrounding his legacy with the presentation of his operation in widely
      consulted urological texts and journals. MATERIALS AND METHODS: A literature
      review was performed of medical, sociological and periodical sources (1851 to the
      present) regarding J. Marion Sims and vesicovaginal fistula repair. RESULTS:
      During the last several decades, while the controversy around Dr. Sims' surgical 
      development has produced a steady stream of articles in the historical and
      popular literature, relatively little mention is found in standard urology
      textbooks or journals. With increased public attention, some have debated the
      removal or modification of public tributes to Dr. Sims. This move has been
      countered by arguments against the validity of judging a 19th century physician
      by modern standards. CONCLUSIONS: While historians, ethicists and the popular
      press have debated Dr. Sims' legacy, medical sources have continued to portray
      him unquestionably as a great figure in medical history. This division keeps the 
      medical profession uninformed and detached from the public debate on his legacy
      and, thus, the larger issues of ethical treatment of surgical patients.
CI  - Copyright (c) 2011 American Urological Association Education and Research, Inc.
      Published by Elsevier Inc. All rights reserved.
FAU - Spettel, Sara
AU  - Spettel S
AD  - Division of Urology, Department of Surgery, Albany Medical College, Albany, New
      York 12208, USA. spettes@mail.amc.edu
FAU - White, Mark Donald
AU  - White MD
LA  - eng
PT  - Biography
PT  - Historical Article
PT  - Journal Article
PT  - Review
DEP - 20110420
PL  - United States
TA  - J Urol
JT  - The Journal of urology
JID - 0376374
SB  - IM
MH  - Female
MH  - Gynecologic Surgical Procedures/*history
MH  - History, 19th Century
MH  - Humans
MH  - Social Problems
MH  - United States
MH  - Urologic Surgical Procedures/*history
MH  - Vesicovaginal Fistula/*history/surgery
PS  - Sims JM
FPS - Sims, J Marion
EDAT- 2011/04/23 06:00
MHDA- 2011/07/20 06:00
CRDT- 2011/04/23 06:00
PHST- 2010/08/10 00:00 [received]
PHST- 2011/04/23 06:00 [entrez]
PHST- 2011/04/23 06:00 [pubmed]
PHST- 2011/07/20 06:00 [medline]
AID - S0022-5347(11)00227-8 [pii]
AID - 10.1016/j.juro.2011.01.077 [doi]
PST - ppublish
SO  - J Urol. 2011 Jun;185(6):2424-7. doi: 10.1016/j.juro.2011.01.077. Epub 2011 Apr
      20.


PMID- 21511102
OWN - NLM
STAT- MEDLINE
DCOM- 20110923
LR  - 20191210
IS  - 1989-7286 (Electronic)
IS  - 0365-6691 (Linking)
VI  - 86
IP  - 3
DP  - 2011 Mar
TI  - [Blepharoplasty: to suture or to use cyanoacrylate?].
PG  - 81-4
LID - 10.1016/j.oftal.2010.12.006 [doi]
AB  - OBJECTIVE: To study the safety and surgical time required when using the tissue
      adhesive 2-ethyl-cyanoacrylate compared with conventional suture in upper lid
      blepharoplasty. METHOD: A retrospective study was performed on 40 eyes of 20
      patients who underwent bilateral upper lid blepharoplasty. In 7 patients,
      continuous non-absorbable suture (6-0 nylon monofilament Ethilon((R)), Ethicon
      Inc., Somerville, NJ) was used for closure of the incision and in 13 patients
      2-ethyl-cyanoacrylate (Epiglue((R)), Meyer -Haake, Germany) was used. The
      variables studied were intraoperative time required to close the incision, the
      cost of the material used and the incidence of infections and suture dehiscence. 
      RESULTS: The average time taken to close the incision was 6.069 minutes with
      cyanoacrylate and 11.914 minutes with conventional suture (P<.05). The price of
      surgical material used was practically similar. No cases of infection or wound
      dehiscence were found. CONCLUSION: The closure of the incision in upper lid
      blepharoplasty using 2-ethyl-cyanoacrylate is a safe, effective, and faster, but 
      not less expensive method than conventional suture.
CI  - Copyright (c) 2010 Sociedad Espanola de Oftalmologia. Published by Elsevier
      Espana. All rights reserved.
FAU - Suriano, M M
AU  - Suriano MM
AD  - Servicio de Oftalmologia, Hospital Clinico Universitario de Valencia, Espana.
      mayerlingsuriano@yahoo.it
FAU - Stirbu, O
AU  - Stirbu O
FAU - Perez M, D
AU  - Perez M D
FAU - Serra Segarra, M
AU  - Serra Segarra M
LA  - spa
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
TT  - Blefaroplastia: inverted question marksuturar o usar cianocrilato?
DEP - 20110310
PL  - Spain
TA  - Arch Soc Esp Oftalmol
JT  - Archivos de la Sociedad Espanola de Oftalmologia
JID - 1304603
RN  - 0 (Cyanoacrylates)
RN  - 0 (Tissue Adhesives)
RN  - 2G95FOH7SF (ethyl 2-cyanoacrylate)
SB  - IM
MH  - Blepharoplasty/economics/*methods
MH  - Costs and Cost Analysis
MH  - Cyanoacrylates/economics/*therapeutic use
MH  - Humans
MH  - Postoperative Complications
MH  - Retrospective Studies
MH  - Spain
MH  - *Suture Techniques/economics
MH  - Sutures/economics
MH  - Tissue Adhesives/economics/*therapeutic use
MH  - *Wound Closure Techniques/economics
EDAT- 2011/04/23 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/04/23 06:00
PHST- 2010/07/13 00:00 [received]
PHST- 2010/11/28 00:00 [revised]
PHST- 2010/12/14 00:00 [accepted]
PHST- 2011/04/23 06:00 [entrez]
PHST- 2011/04/23 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - S0365-6691(11)00003-7 [pii]
AID - 10.1016/j.oftal.2010.12.006 [doi]
PST - ppublish
SO  - Arch Soc Esp Oftalmol. 2011 Mar;86(3):81-4. doi: 10.1016/j.oftal.2010.12.006.
      Epub 2011 Mar 10.


PMID- 21511096
OWN - NLM
STAT- MEDLINE
DCOM- 20110815
LR  - 20211020
IS  - 1557-8216 (Electronic)
IS  - 0272-5231 (Linking)
VI  - 32
IP  - 2
DP  - 2011 Jun
TI  - Lung retransplantation.
PG  - 367-77
LID - 10.1016/j.ccm.2011.02.013 [doi]
AB  - Lung retransplantation comprises a small proportion of lung transplants performed
      throughout the world, but has become more frequent in recent years. The selection
      criteria for lung retransplantation are similar to those for initial lung
      transplant. Survival after lung retransplantation has improved over time, but
      still lags behind that of initial lung transplantation. These differences in
      outcome may be attributable to medical comorbidities. Lung retransplantation
      appears to be ethically justified; however, the optimal approach to lung
      allocation for retransplantation needs to be defined.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Kawut, Steven M
AU  - Kawut SM
AD  - Pulmonary, Allergy, and Critical Care Division, Department of Medicine, and the
      Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania
      School of Medicine, Philadelphia, PA 19104, USA. kawut@upenn.edu
LA  - eng
GR  - R01 HL086719/HL/NHLBI NIH HHS/United States
GR  - R01 HL086719-04/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Clin Chest Med
JT  - Clinics in chest medicine
JID - 7907612
SB  - IM
MH  - Humans
MH  - *Lung Transplantation/ethics/methods/statistics & numerical data
MH  - Patient Selection
MH  - *Reoperation/ethics/methods/statistics & numerical data
MH  - Treatment Outcome
PMC - PMC3081645
MID - NIHMS274685
EDAT- 2011/04/23 06:00
MHDA- 2011/08/16 06:00
CRDT- 2011/04/23 06:00
PHST- 2011/04/23 06:00 [entrez]
PHST- 2011/04/23 06:00 [pubmed]
PHST- 2011/08/16 06:00 [medline]
AID - S0272-5231(11)00027-X [pii]
AID - 10.1016/j.ccm.2011.02.013 [doi]
PST - ppublish
SO  - Clin Chest Med. 2011 Jun;32(2):367-77. doi: 10.1016/j.ccm.2011.02.013.


PMID- 21510519
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20110422
IS  - 0017-8012 (Print)
IS  - 0017-8012 (Linking)
VI  - 89
IP  - 4
DP  - 2011 Apr
TI  - Ethical breakdowns.
PG  - 58-65, 137
AB  - Companies are spending a great deal of time and money to install codes of ethics,
      ethics training, compliance programs, and in-house watchdogs. If these efforts
      worked, the money would be well spent. But unethical behavior appears to be on
      the rise. The authors observe that even the best-intentioned executives may be
      unaware of their own or their employees' unethical behavior. Drawing from
      extensive research on cognitive biases, they offer five reasons for this
      blindness and suggest what to do about them. Ill-conceived goals may actually
      encourage negative behavior. Brainstorm unintended consequences when devising
      your targets. Motivated blindness makes us overlook unethical behavior when
      remaining ignorant would benefit us. Root out conflicts of interest. Indirect
      blindness softens our assessment of unethical behavior when it's carried out by
      third parties. Take ownership of the implications when you outsource work. The
      slippery slope mutes our awareness when unethical behavior develops gradually. Be
      alert for even trivial infractions and investigate them immediately. Overvaluing 
      outcomes may lead us to give a pass to unethical behavior. Examine good outcomes 
      to ensure they're not driven by unethical tactics.
FAU - Bazerman, Max H
AU  - Bazerman MH
AD  - Harvard Business School, USA.
FAU - Tenbrunsel, Ann E
AU  - Tenbrunsel AE
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Harv Bus Rev
JT  - Harvard business review
JID - 9875796
MH  - Administrative Personnel/*ethics
MH  - Commerce/*ethics
MH  - Humans
MH  - United States
EDAT- 2011/04/23 06:00
MHDA- 2011/06/03 06:00
CRDT- 2011/04/23 06:00
PHST- 2011/04/23 06:00 [entrez]
PHST- 2011/04/23 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
PST - ppublish
SO  - Harv Bus Rev. 2011 Apr;89(4):58-65, 137.


PMID- 21510516
OWN - NLM
STAT- MEDLINE
DCOM- 20110524
LR  - 20110422
IS  - 0193-7758 (Print)
IS  - 0193-7758 (Linking)
VI  - 33
IP  - 2
DP  - 2011 Mar-Apr
TI  - Ideal ethical standards for contraceptive use in research.
PG  - 19-20
FAU - Baylis, Francoise
AU  - Baylis F
FAU - Kaposy, Chris
AU  - Kaposy C
LA  - eng
PT  - Comment
PT  - Letter
PL  - United States
TA  - IRB
JT  - IRB
JID - 7906878
RN  - 0 (Contraceptive Agents)
SB  - IM
CON - IRB. 2010 Nov-Dec;32(6):13-6. PMID: 21375115
MH  - Biomedical Research/*ethics
MH  - *Contraceptive Agents/adverse effects
MH  - Female
MH  - Humans
EDAT- 2011/04/23 06:00
MHDA- 2011/05/25 06:00
CRDT- 2011/04/23 06:00
PHST- 2011/04/23 06:00 [entrez]
PHST- 2011/04/23 06:00 [pubmed]
PHST- 2011/05/25 06:00 [medline]
PST - ppublish
SO  - IRB. 2011 Mar-Apr;33(2):19-20.


PMID- 21510329
OWN - HMD
STAT- MEDLINE
DCOM- 20110623
LR  - 20191027
IS  - 0886-7356 (Print)
IS  - 0886-7356 (Linking)
VI  - 26
IP  - 1
DP  - 2011
TI  - Making time for the children: self-temporalization and the cultivation of the
      antisuicidal subject in south India.
PG  - 112-37
AB  - This article examines suicide prevention among children in India's "suicide
      capital" of Kerala to interrogate the ways temporalization practices inform the
      cultivation of ethical, life-avowing subjects in late capitalism. As economic
      liberalization and migration expand consumer aspiration in Kerala, mental health 
      experts link the quickening of material gratification in middle-class parenting
      to the production of insatiable, maladjusted, and impulsively suicidal children. 
      Experiences of accelerated time through consumption in "modern" Kerala parenting 
      practice reflect ideas about the threats of globalization that are informed both 
      by national economic shifts and by nostalgia for the state's communist and
      developmentalist histories, suggesting that late capitalism's time-space
      compression is not a universalist phenomenon so much as one that is unevenly
      experienced through regionally specific renderings of the past. I demonstrate how
      experts position the Malayali child as uniquely vulnerable to the fatal dangers
      of immediate gratification, and thus exhort parents to retemporalize children
      through didactic games built around the deferral of desires for everyday consumer
      items. Teaching children how to wait as a pleasurable and explicitly antisuicidal
      way of being reveals anxieties, contestations, and contradictions concerning what
      ought to constitute "quality" investment in children as temporal subjects of late
      capitalism. The article concludes by bringing efforts to save elite lives into
      conversation with suicide prevention among migrants to draw out the ways distinct
      vulnerabilities and conditions of precarity situate waiting subjects in radically
      different ways against the prospect of self-destruction.
FAU - Chua, Jocelyn Lim
AU  - Chua JL
AD  - University of North Carolina at Chapel Hill.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - Cult Anthropol
JT  - Cultural anthropology : journal of the Society for Cultural Anthropology
JID - 101092924
MH  - *Family Health/ethnology
MH  - Family Relations/ethnology/legislation & jurisprudence
MH  - History, 19th Century
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - India/ethnology
MH  - Nuclear Family/ethnology/history/psychology
MH  - *Parent-Child Relations/ethnology/legislation & jurisprudence
MH  - Parenting/ethnology/history/psychology
MH  - Population Groups/education/ethnology/history/legislation &
      jurisprudence/psychology
MH  - *Preventive Psychiatry/education/history
MH  - Social Class/history
MH  - Social Conditions/economics/history/legislation & jurisprudence
MH  - *Socioeconomic Factors/history
MH  - *Suicide/economics/ethnology/history/legislation & jurisprudence/psychology
EDAT- 2011/04/23 06:00
MHDA- 2011/06/24 06:00
CRDT- 2011/04/23 06:00
PHST- 2011/04/23 06:00 [entrez]
PHST- 2011/04/23 06:00 [pubmed]
PHST- 2011/06/24 06:00 [medline]
AID - 10.1111/j.1548-1360.2010.01082.x [doi]
PST - ppublish
SO  - Cult Anthropol. 2011;26(1):112-37. doi: 10.1111/j.1548-1360.2010.01082.x.


PMID- 21510226
OWN - NLM
STAT- MEDLINE
DCOM- 20110512
LR  - 20151119
IS  - 0300-9009 (Print)
IS  - 0300-9009 (Linking)
VI  - 111
IP  - 1
DP  - 2011 Mar
TI  - Impulse control disorders in patients with Parkinson's disease.
PG  - 3-9
AB  - In patients with Parkinson's disease with higher prevalence than in current
      population there appear pathological behaviours characterized by compulsion,
      repetitiveness and impulsivity, which are connected with material profit or
      pleasurable experience. They are, in particular, pathological gambling,
      hypersexuality, compulsive shopping and compulsive eating (in the literature they
      are collectively referred to as impulse control disorders). Pathological
      preoccupation with repeated mechanical activities (so-called punding) and
      excessive compulsive intake of dopaminergic medication (so-called dopamine
      dysregulation syndrome or also syndrome of hedonistic homeostatic dysregulation) 
      are of similar nature. The paper treats briefly the risk factors and prevalence
      of these pathological behaviours. In current clinical practice, these psychiatric
      complications frequently escape doctors' attention, they are underdiagnosed.
      Although no generally valid recommendations for their therapy are currently
      available, they can be influenced medically. Of advantage can be modified
      dopaminergic medication (usually dose reduction ofdopaminergic agonists);
      multidisciplinary approach to the problem is appropriate. The pathological
      behaviours given above can frequently lead to considerable material losses and
      markedly aggravate patients' handicap in the social sphere; it can be expected
      that in the future they can become a problem also from the ethical and legal
      points of view.
FAU - Gescheidt, Tomas
AU  - Gescheidt T
AD  - Department of Neurology St. Anne's Hospital Medical Faculty Masaryk University
      Brno, Czech Republic.
FAU - Bares, Martin
AU  - Bares M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Italy
TA  - Acta Neurol Belg
JT  - Acta neurologica Belgica
JID - 0247035
SB  - IM
MH  - Disruptive, Impulse Control, and Conduct
      Disorders/diagnosis/epidemiology/*etiology/prevention & control
MH  - Gambling/etiology/psychology
MH  - Humans
MH  - Parkinson Disease/*complications/epidemiology/*psychology
MH  - Quality of Life
MH  - Risk Factors
EDAT- 2011/04/23 06:00
MHDA- 2011/05/13 06:00
CRDT- 2011/04/23 06:00
PHST- 2011/04/23 06:00 [entrez]
PHST- 2011/04/23 06:00 [pubmed]
PHST- 2011/05/13 06:00 [medline]
PST - ppublish
SO  - Acta Neurol Belg. 2011 Mar;111(1):3-9.


PMID- 21510176
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20110421
IS  - 1029-4864 (Print)
IS  - 1029-4864 (Linking)
VI  - 66
IP  - 1
DP  - 2011 Feb
TI  - Dental ethics case 8. Patient declines my proposed treatment plan.
PG  - 34
FAU - Naidoo, S
AU  - Naidoo S
AD  - Department of Community Oral Health, University of the Western Cape, Private Bag 
      XI, Tygerberg 7505. suenaidoo@uwc.ac.za
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - SADJ
JT  - SADJ : journal of the South African Dental Association = tydskrif van die
      Suid-Afrikaanse Tandheelkundige Vereniging
JID - 9812497
MH  - Beneficence
MH  - Dental Care
MH  - Dentist-Patient Relations/ethics
MH  - Dentists/*ethics
MH  - *Ethics, Dental
MH  - Female
MH  - Humans
MH  - Informed Consent/ethics
MH  - Patient Care Planning/ethics
MH  - Patient Participation
MH  - Personal Autonomy
MH  - Treatment Refusal/*ethics
EDAT- 2011/04/23 06:00
MHDA- 2011/06/03 06:00
CRDT- 2011/04/23 06:00
PHST- 2011/04/23 06:00 [entrez]
PHST- 2011/04/23 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
PST - ppublish
SO  - SADJ. 2011 Feb;66(1):34.


PMID- 21509714
OWN - NLM
STAT- MEDLINE
DCOM- 20130409
LR  - 20211020
IS  - 1439-0221 (Electronic)
IS  - 0032-0943 (Linking)
VI  - 77
IP  - 13
DP  - 2011 Sep
TI  - Control in the middle (CIM) for three-period crossover studies.
PG  - 1473-6
LID - 10.1055/s-0030-1271044 [doi]
AB  - Three-period crossover studies can be efficient and convenient methods of
      conducting Phase II clinical trials. Non-randomly placing control in the middle
      (CIM) has not been practiced but may be extremely useful in studies testing
      herbal products for which placebos are not available, or for distinguishing
      between behavioral and biological effects. Furthermore, this design can serve as 
      a valuable addition to classical studies of either (a) two competing treatments
      or (b) treatment versus placebo versus an open label "nothing" as the control.
      Therefore, we propose rigorous designs that will help practitioners efficiently
      answer research questions where (1) two active treatments need to be compared
      against each other with treatment vs. placebo comparisons being of secondary
      importance; (2) a single active treatment needs to be tested where no placebo is 
      available; or (3) the placebo effect is of interest in a treatment vs. placebo
      trial. For studies where no placebo is available, deception will be required,
      with participants told that in one randomly selected period (#1 or #3) they will 
      receive the active treatment, and that they will receive a new experimental inert
      placebo in the other period. Assuming this design is approved by an ethics
      committee, it can be very useful in biomedical research.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Shuster, Jonathan
AU  - Shuster J
AD  - Department of Health Outcomes and Policy, College of Medicine (COM), University
      of Florida, Gainesville, Florida 32610-0177, USA. jshuster@biostat.ufl.edu
FAU - Anton, Stephen D
AU  - Anton SD
FAU - Theriaque, Douglas
AU  - Theriaque D
FAU - Yoon, Saunjoo
AU  - Yoon S
LA  - eng
GR  - K23 AT004251-02/AT/NCCIH NIH HHS/United States
GR  - K23 AT004251/AT/NCCIH NIH HHS/United States
GR  - M01RR00082/RR/NCRR NIH HHS/United States
GR  - UL1 RR029890-02/RR/NCRR NIH HHS/United States
GR  - 1UL 1RR029890/RR/NCRR NIH HHS/United States
GR  - U54RR025208/RR/NCRR NIH HHS/United States
GR  - UL1 RR029890-01/RR/NCRR NIH HHS/United States
GR  - K23AT004251/AT/NCCIH NIH HHS/United States
GR  - M01 RR000082/RR/NCRR NIH HHS/United States
GR  - UL1 RR029890/RR/NCRR NIH HHS/United States
GR  - P30 AG028740/AG/NIA NIH HHS/United States
GR  - K23 AT004251-03/AT/NCCIH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110420
PL  - Germany
TA  - Planta Med
JT  - Planta medica
JID - 0066751
RN  - 0 (Plant Preparations)
SB  - IM
MH  - Clinical Trials as Topic/*methods/standards
MH  - Cross-Over Studies
MH  - Deception
MH  - Humans
MH  - Placebo Effect
MH  - Plant Preparations/therapeutic use
MH  - *Research Design
PMC - PMC3296130
MID - NIHMS357762
EDAT- 2011/04/22 06:00
MHDA- 2013/04/10 06:00
CRDT- 2011/04/22 06:00
PHST- 2011/04/22 06:00 [entrez]
PHST- 2011/04/22 06:00 [pubmed]
PHST- 2013/04/10 06:00 [medline]
AID - 10.1055/s-0030-1271044 [doi]
PST - ppublish
SO  - Planta Med. 2011 Sep;77(13):1473-6. doi: 10.1055/s-0030-1271044. Epub 2011 Apr
      20.


PMID- 21509554
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20211020
IS  - 1826-6983 (Electronic)
IS  - 0033-8362 (Linking)
VI  - 116
IP  - 6
DP  - 2011 Sep
TI  - Forensic radiology and personal identification of unidentified bodies: a review.
PG  - 960-8
LID - 10.1007/s11547-011-0677-6 [doi]
AB  - Personal identification of unidentified bodies is crucial for ethical, juridical 
      and civil reasons and is performed through comparison between biological data
      obtained from the cadaver and antemortem material from one or more missing
      persons to whom the body may have belonged in life. The increasing applications
      of forensic radiology and the wide use of conventional radiography and computed
      tomography (CT) in routine clinical practice demonstrate the potential of these
      technologies as tools for verifying the correspondence between an unidentified
      body and an identity suspect. This paper reviews the literature concerning the
      application of forensic radiology to the difficult issue of personal
      identification. Despite the increasing importance of the comparison between
      radiographic and CT findings, numerous limitations still need to be overcome,
      including the fact that few forensic centres have access to sophisticated X-ray
      technologies and that the reliability of those technologies for detecting
      specific morphological traits and bone lesions is a matter of intense debate. In 
      addition, as with other morphological methods for identification, comparisons
      between antemortem and postmortem data require standardisation and statistical
      analysis, especially in Europe where there are very few indications concerning
      the admission in court of evidence obtained by anthropological and radiological
      methods. In the future, with developments in radiographic technologies and
      increasing numbers of studies on their application to the forensic setting,
      radiology will become one of the most useful tools in the field of personal
      identification.
FAU - Ciaffi, R
AU  - Ciaffi R
AD  - LABANOF, Laboratorio di Antropologia e Odontologia Forense, Sezione di Medicina
      Legale, DMU-Dipartimento di Morfologia Umana e Scienze Biomediche, Universita
      degli Studi di Milano, Via Mangiagalli 37, Milano, Italy.
FAU - Gibelli, D
AU  - Gibelli D
FAU - Cattaneo, C
AU  - Cattaneo C
LA  - eng
LA  - ita
PT  - Journal Article
PT  - Review
DEP - 20110419
PL  - Italy
TA  - Radiol Med
JT  - La Radiologia medica
JID - 0177625
SB  - IM
MH  - Forensic Medicine/instrumentation/*methods
MH  - Humans
MH  - Postmortem Changes
MH  - *Radiography
MH  - Time Factors
MH  - Tomography, X-Ray Computed
EDAT- 2011/04/22 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/04/22 06:00
PHST- 2010/08/12 00:00 [received]
PHST- 2010/11/19 00:00 [accepted]
PHST- 2011/04/22 06:00 [entrez]
PHST- 2011/04/22 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/s11547-011-0677-6 [doi]
PST - ppublish
SO  - Radiol Med. 2011 Sep;116(6):960-8. doi: 10.1007/s11547-011-0677-6. Epub 2011 Apr 
      19.


PMID- 21509188
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1942-0889 (Electronic)
IS  - 1942-0889 (Linking)
VI  - 4
IP  - 1
DP  - 2011 Jan
TI  - Ethical advantages of using domestic bird species for magnetic orientation
      research.
PG  - 84-5
LID - 10.4161/cib.4.1.14064 [doi]
AB  - Identifying the mechanism in birds that controls magnetic orientation behavior is
      proving elusive and is currently attracting a plethora of research activity. Much
      of this research involves wild birds that are caught in nets, tested and
      released. Ethical concerns regarding these experiments are likely to encompass
      the welfare of animals, their "rights" and conservation issues. Recently, Pekin
      ducks derived from migratory ancestors have been shown to posses a magnetic
      compass in a simple conditioning procedure. The use of domestic bird species
      provides a refinement in the ethics of animal experimentation since these birds
      are not caught in nets, are less fearful of humans and their use does not raise
      conservation concerns. The study of magnetic orientation is a high profile and
      fascinating areas of animal behavior research and one in which behavioral
      scientists should be seen to actively embrace the principles of the 3R's.
FAU - Freire, Rafael
AU  - Freire R
AD  - School of Animal and Veterinary Sciences; Charles Sturt University; Wagga Wagga, 
      NSW, Australia.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Commun Integr Biol
JT  - Communicative & integrative biology
JID - 101478473
PMC - PMC3073280
OTO - NOTNLM
OT  - behavior
OT  - domestic birds
OT  - magnetic orientation
OT  - research ethics
OT  - welfare
EDAT- 2011/04/22 06:00
MHDA- 2011/04/22 06:01
CRDT- 2011/04/22 06:00
PHST- 2011/11/01 00:00 [received]
PHST- 2011/11/01 00:00 [accepted]
PHST- 2011/04/22 06:00 [entrez]
PHST- 2011/04/22 06:00 [pubmed]
PHST- 2011/04/22 06:01 [medline]
AID - 10.4161/cib.4.1.14064 [doi]
PST - ppublish
SO  - Commun Integr Biol. 2011 Jan;4(1):84-5. doi: 10.4161/cib.4.1.14064.


PMID- 21508761
OWN - NLM
STAT- MEDLINE
DCOM- 20150324
LR  - 20220318
IS  - 1873-233X (Electronic)
IS  - 0029-7844 (Linking)
VI  - 117
IP  - 5
DP  - 2011 May
TI  - Obstetric ethics: an essential dimension of planned home birth.
PG  - 1183-1187
LID - 10.1097/AOG.0b013e3182172a97 [doi]
AB  - The American College of Obstetricians and Gynecologists (the College) Committee
      Opinion, "Planned Home Birth," invokes two core concepts of obstetric ethics, the
      right of a woman to make a medically informed decision about delivery and the
      informed consent process. We set out a framework for obstetric ethics that
      empowers the autonomy of pregnant women by focusing on when, in beneficence-based
      clinical judgment, clinical management should be offered, should be recommended, 
      and should be recommended against in the informed consent process. Using this
      ethical framework, we show that the College statement does not provide adequate
      guidance to obstetricians in fulfilling their ethical obligations in the informed
      consent process with pregnant women who express an interest in, or preference for
      planned home birth. Obstetricians have an ethical obligation to disclose the
      increased risks of perinatal and neonatal mortality and morbidity from planned
      home birth in the context of American healthcare and should recommend against it.
      Obstetricians should recommend hospital-based delivery and respond to refusal of 
      these recommendations with respectful persuasion. As a matter of
      beneficence-based professional integrity, obstetricians should not participate in
      planned home birth. At the same time, obstetricians have a beneficence-based
      obligation to continue to provide prenatal and emergency obstetric care. The
      obstetric profession should continuously strive to make hospital births more
      humane and support home-birth-like environments in the hospital as well as
      continuously improve safety for both pregnant and fetal patients.
FAU - Chervenak, Frank A
AU  - Chervenak FA
AD  - From the Department of Obstetrics and Gynecology, Weill Medical College of
      Cornell University, New York, New York; the Center for Medical Ethics and Health 
      Policy, Baylor College of Medicine, Houston, Texas; and the Center for Mother and
      Child, Marburg University Hospital, Marburg, Germany.
FAU - McCullough, Laurence B
AU  - McCullough LB
FAU - Arabin, Birgit
AU  - Arabin B
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Obstet Gynecol
JT  - Obstetrics and gynecology
JID - 0401101
SB  - IM
CON - Obstet Gynecol. 2011 Feb;117(2 Pt 1):425-8. PMID: 21252776
CIN - Obstet Gynecol. 2011 Aug;118(2 Pt 1):357; author reply 357-8. PMID: 21775854
CIN - Obstet Gynecol. 2011 Aug;118(2 Pt 1):357; author reply 357-8. PMID: 21775855
MH  - Female
MH  - *Home Childbirth
MH  - Humans
MH  - Pregnancy
EDAT- 2011/04/22 06:00
MHDA- 2015/03/25 06:00
CRDT- 2011/04/22 06:00
PHST- 2011/04/22 06:00 [entrez]
PHST- 2011/04/22 06:00 [pubmed]
PHST- 2015/03/25 06:00 [medline]
AID - 10.1097/AOG.0b013e3182172a97 [doi]
AID - 00006250-201105000-00024 [pii]
PST - ppublish
SO  - Obstet Gynecol. 2011 May;117(5):1183-1187. doi: 10.1097/AOG.0b013e3182172a97.


PMID- 21508760
OWN - NLM
STAT- MEDLINE
DCOM- 20130708
LR  - 20210107
IS  - 1873-233X (Electronic)
IS  - 0029-7844 (Linking)
VI  - 117
IP  - 5
DP  - 2011 May
TI  - Home birth: what are physicians' ethical obligations when patient choices may
      carry increased risk?
PG  - 1179-1182
LID - 10.1097/AOG.0b013e3182167413 [doi]
AB  - Patient choices and plans may sometimes carry increased risk or include
      alternatives that individual physicians feel uncomfortable supporting or
      recommending. We consider in this commentary how the ethical principles of
      respect for autonomy and nonmaleficence can be balanced using, among other
      examples, the choice by some for a home birth. We discuss how absolute rather
      than relative risk should guide individuals' evaluation of patient choices, and
      how in some circumstances the value and safety added by a physician's
      participation may outweigh a potentially small increment in absolute risk that a 
      particular patient choice carries.
FAU - Ecker, Jeffrey
AU  - Ecker J
AD  - From the Department of Obstetrics and Gynecology, Massachusetts General Hospital,
      Harvard Medical School, Boston, Massachusetts; and the Department of Obstetrics
      and Gynecology, Maimonides Medical Center and SUNY Downstate Medical Center, New 
      York, New York.
FAU - Minkoff, Howard
AU  - Minkoff H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Obstet Gynecol
JT  - Obstetrics and gynecology
JID - 0401101
SB  - IM
MH  - *Ethics, Medical
MH  - Female
MH  - Home Childbirth/*ethics
MH  - Humans
MH  - Patient Acceptance of Health Care
MH  - Personal Autonomy
MH  - Physician-Patient Relations
MH  - Pregnancy
MH  - Risk
EDAT- 2011/04/22 06:00
MHDA- 2013/07/09 06:00
CRDT- 2011/04/22 06:00
PHST- 2011/04/22 06:00 [entrez]
PHST- 2011/04/22 06:00 [pubmed]
PHST- 2013/07/09 06:00 [medline]
AID - 10.1097/AOG.0b013e3182167413 [doi]
AID - 00006250-201105000-00023 [pii]
PST - ppublish
SO  - Obstet Gynecol. 2011 May;117(5):1179-1182. doi: 10.1097/AOG.0b013e3182167413.


PMID- 21508722
OWN - NLM
STAT- MEDLINE
DCOM- 20110729
LR  - 20111227
IS  - 1539-0667 (Electronic)
IS  - 1533-1458 (Linking)
VI  - 34
IP  - 3
DP  - 2011 May-Jun
TI  - Developing an effective quantitative research proposal.
PG  - 181-6
LID - 10.1097/NAN.0b013e3182117204 [doi]
AB  - In 2010, the Infusion Nurses Society began work to identify research priorities
      for infusion nursing. Nurses need to understand the research process and become
      proficient in collaboration to promote research in their specialty. One of the
      most important components of conducting research is the written research
      proposal. A poorly written proposal may result in denial of funding, rejected
      publications, and prolonged discussion and revision at the institutional or
      ethics review board. This article provides an overview of the elements needed in 
      a research proposal, identifies institutional review board requirements, and
      highlights important criteria for recruitment and consent of subjects.
FAU - Merrill, Katreena Collette
AU  - Merrill KC
AD  - College of Nursing, Brigham Young University, 563 SWKT, Provo, UT 84602, USA.
      Katreena.Merrill@byu.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Infus Nurs
JT  - Journal of infusion nursing : the official publication of the Infusion Nurses
      Society
JID - 101124170
CIN - J Infus Nurs. 2011 Nov-Dec;34(6):345-6. PMID: 22101627
MH  - Infusions, Intravenous
MH  - *Nursing Research
MH  - Societies, Nursing
MH  - United States
EDAT- 2011/04/22 06:00
MHDA- 2011/07/30 06:00
CRDT- 2011/04/22 06:00
PHST- 2011/04/22 06:00 [entrez]
PHST- 2011/04/22 06:00 [pubmed]
PHST- 2011/07/30 06:00 [medline]
AID - 10.1097/NAN.0b013e3182117204 [doi]
AID - 00129804-201105000-00005 [pii]
PST - ppublish
SO  - J Infus Nurs. 2011 May-Jun;34(3):181-6. doi: 10.1097/NAN.0b013e3182117204.


PMID- 21508425
OWN - NLM
STAT- MEDLINE
DCOM- 20111212
LR  - 20110519
IS  - 1473-4265 (Electronic)
IS  - 1468-215X (Linking)
VI  - 37
IP  - 1
DP  - 2011 Jun
TI  - Moral erosion: how can medical professionals safeguard against the slippery
      slope?
PG  - 53-5
LID - 10.1136/jmh.2010.006296 [doi]
AB  - The extensive participation of German physicians in the atrocities of the
      Holocaust raises many questions concerning the potential for moral erosion in
      medicine. What circumstances and methods of rationalisation allowed doctors to
      turn from healers into accomplices of genocide? Are physicians still vulnerable
      to corruption of their guiding principles and, if so, what can be done to prevent
      this process from occurring? With these thoughts in mind, the author reflects on 
      his experiences participating in the Fellowships at Auschwitz for the Study of
      Professional Ethics program and offers a medical student's perspective on the
      ethical issues encountered in clinical training and the practice of medicine.
FAU - Liebowitz, Jason
AU  - Liebowitz J
AD  - Johns Hopkins School of Medicine, Baltimore, MD 21202, USA. jliebow3@jhmi.edu
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110420
PL  - United States
TA  - Med Humanit
JT  - Medical humanities
JID - 100959585
SB  - IM
MH  - Ethics, Medical/*history
MH  - Ethics, Professional/*history
MH  - Germany
MH  - History, 20th Century
MH  - Holocaust/*history
MH  - Homicide/*history
MH  - Humans
MH  - Physicians/ethics/*history
EDAT- 2011/04/22 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/04/22 06:00
PHST- 2011/04/22 06:00 [entrez]
PHST- 2011/04/22 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - jmh.2010.006296 [pii]
AID - 10.1136/jmh.2010.006296 [doi]
PST - ppublish
SO  - Med Humanit. 2011 Jun;37(1):53-5. doi: 10.1136/jmh.2010.006296. Epub 2011 Apr 20.


PMID- 21508253
OWN - NLM
STAT- MEDLINE
DCOM- 20120118
LR  - 20110808
IS  - 1049-7323 (Print)
IS  - 1049-7323 (Linking)
VI  - 21
IP  - 9
DP  - 2011 Sep
TI  - Ethical reflections: examining reflexivity through the narrative paradigm.
PG  - 1283-94
LID - 10.1177/1049732311405800 [doi]
AB  - Being reflexive and providing these reflections for public scrutiny is often
      considered a key element of ethical, rigorous qualitative research. Prevalent
      conceptualizations of reflexivity, however, need interrogating and sharpening. We
      aim to contribute to this by examining reflexive practice, and in particular
      researchers' reflexive accounts, through the lens of the narrative paradigm. Our 
      aim is to demonstrate that acknowledging the role of narrative reconstruction in 
      reflexivity creates more ethical research, and that it is therefore crucial for
      researchers to more explicitly recognize this. Both authors present an analysis
      of one particular exchange between interviewer and participant. This analysis
      highlights that despite our best efforts at "doing reflexivity," both immediately
      following and when reflecting back on an interview, there are influential factors
      that escape our gaze. Reflections of the past are particularly imperfect. Without
      fully recognizing this, we are not utilizing all the tools available for ensuring
      honest, ethical research.
FAU - Bishop, Emily C
AU  - Bishop EC
AD  - School of Sociology and Social Work, University of Tasmania, Launceston,
      Tasmania, Australia. Emily.Bishop@utas.edu.au
FAU - Shepherd, Marie L
AU  - Shepherd ML
LA  - eng
PT  - Journal Article
DEP - 20110420
PL  - United States
TA  - Qual Health Res
JT  - Qualitative health research
JID - 9202144
MH  - *Adaptation, Psychological
MH  - *Ethics, Research
MH  - Humans
MH  - *Narration
MH  - Postmodernism
MH  - Psychological Theory
MH  - *Qualitative Research
MH  - Research Personnel/*psychology
MH  - Self Concept
MH  - Social Identification
EDAT- 2011/04/22 06:00
MHDA- 2012/01/19 06:00
CRDT- 2011/04/22 06:00
PHST- 2011/04/22 06:00 [entrez]
PHST- 2011/04/22 06:00 [pubmed]
PHST- 2012/01/19 06:00 [medline]
AID - 1049732311405800 [pii]
AID - 10.1177/1049732311405800 [doi]
PST - ppublish
SO  - Qual Health Res. 2011 Sep;21(9):1283-94. doi: 10.1177/1049732311405800. Epub 2011
      Apr 20.


PMID- 21508192
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20110421
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 5
DP  - 2011 May
TI  - Harris, harmed states, and sexed bodies.
PG  - 276-9
LID - 10.1136/jme.2010.039982 [doi]
AB  - This paper criticises John Harris's attempts to defend an account of a 'harmed
      condition' that can stand independently of intuitions about what is 'normal'. I
      argue that because Homo sapiens is a sexually dimorphic species, determining
      whether a particular individual is in a harmed condition or not will sometimes
      require making reference to the normal capacities of their sex. Consequently,
      Harris's account is unable to play the role he intends for it in debates about
      the ethics of human enhancement.
FAU - Sparrow, Robert
AU  - Sparrow R
AD  - Centre for Human Bioethics, School of Philosophical, Historical, and
      International Studies, Monash University, Clayton, Victoria 3800, Australia.
      robert.sparrow@arts.monash.edu.au
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
CIN - J Med Ethics. 2011 May;37(5):262-6. PMID: 21508191
MH  - *Bioethical Issues
MH  - Decision Making/*ethics
MH  - Female
MH  - Genetic Diseases, Inborn/*prevention & control
MH  - Genetic Enhancement/*ethics
MH  - Humans
MH  - Male
MH  - Reproductive Behavior/*ethics
MH  - Social Values
EDAT- 2011/04/22 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/04/22 06:00
PHST- 2011/04/22 06:00 [entrez]
PHST- 2011/04/22 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 37/5/276 [pii]
AID - 10.1136/jme.2010.039982 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 May;37(5):276-9. doi: 10.1136/jme.2010.039982.


PMID- 21507277
OWN - NLM
STAT- MEDLINE
DCOM- 20110816
LR  - 20220317
IS  - 1497-0015 (Electronic)
IS  - 0706-7437 (Linking)
VI  - 56
IP  - 4
DP  - 2011 Apr
TI  - Are Canadians providing advance directives about health care and research
      participation in the event of decisional incapacity?
PG  - 209-18
AB  - OBJECTIVE: Advance planning for health care and research participation has been
      promoted as a mechanism to retain some control over one's life, and ease
      substitute decision making, in the event of decisional incapacity. Limited data
      are available on Canadians' current advance planning activities. We conducted a
      postal survey to estimate the frequency with which Canadians communicate their
      preferences about health care and research should they become incapacitated.
      METHOD: We surveyed 5 populations (older adults, informal caregivers, physicians,
      researchers in aging, and research ethics board members) from Nova Scotia,
      Ontario, Alberta, and British Columbia. We asked respondents whether they had
      expressed their preferences regarding a substitute decision maker, health care,
      and research participation in the event of incapacity. RESULTS: Two out of 3
      respondents (62.0%; 95% CI 59.1% to 64.8%) had been advised to communicate their 
      health care preferences in advance. Oral expression of wishes was reported by
      69.1% of respondents (95% CI 66.8% to 71.3%), and written expression by 46.7%
      (95% CI 44.3% to 49.2%). Among respondents who had expressed wishes in advance
      (orally or in writing), 91.2% had chosen a substitute decision maker, 80.9% had
      voiced health care preferences, and 19.5% had voiced preferences regarding
      research participation. Having been advised to communicate wishes was a strong
      predictor of the likelihood of having done so. CONCLUSIONS: Advance planning has 
      increased over the last 2 decades in Canada. Nonetheless, further efforts are
      needed to encourage Canadians to voice their health care and research preferences
      in the event of incapacity. Physicians are well situated to promote advance
      planning to Canadians.
FAU - Bravo, Gina
AU  - Bravo G
AD  - Department of Community Health Sciences, University of Sherbrooke, Sherbrooke,
      Quebec. Gina.Bravo@USherbrooke.ca
FAU - Dubois, Marie-France
AU  - Dubois MF
FAU - Cohen, Carole
AU  - Cohen C
FAU - Wildeman, Sheila
AU  - Wildeman S
FAU - Graham, Janice
AU  - Graham J
FAU - Painter, Karen
AU  - Painter K
FAU - Bellemare, Suzanne
AU  - Bellemare S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Can J Psychiatry
JT  - Canadian journal of psychiatry. Revue canadienne de psychiatrie
JID - 7904187
SB  - IM
MH  - Adult
MH  - *Advance Care Planning/ethics/organization & administration/statistics &
      numerical data
MH  - Advance Directive Adherence/standards
MH  - *Advance Directives/ethics/psychology
MH  - Aged
MH  - Attitude of Health Personnel
MH  - *Bioethical Issues
MH  - Canada
MH  - Choice Behavior
MH  - Decision Making
MH  - Female
MH  - Health Services Needs and Demand
MH  - Humans
MH  - Male
MH  - Mental Competency
MH  - Middle Aged
MH  - Patient Advocacy
MH  - Patient Participation/psychology
MH  - *Patient Rights
MH  - Patient Selection/*ethics
MH  - Physician-Patient Relations/ethics
EDAT- 2011/04/22 06:00
MHDA- 2011/08/17 06:00
CRDT- 2011/04/22 06:00
PHST- 2011/04/22 06:00 [entrez]
PHST- 2011/04/22 06:00 [pubmed]
PHST- 2011/08/17 06:00 [medline]
AID - 10.1177/070674371105600404 [doi]
PST - ppublish
SO  - Can J Psychiatry. 2011 Apr;56(4):209-18. doi: 10.1177/070674371105600404.


PMID- 21507276
OWN - NLM
STAT- MEDLINE
DCOM- 20110816
LR  - 20170214
IS  - 1497-0015 (Electronic)
IS  - 0706-7437 (Linking)
VI  - 56
IP  - 4
DP  - 2011 Apr
TI  - Placebos in clinical practice: comparing attitudes, beliefs, and patterns of use 
      between academic psychiatrists and nonpsychiatrists.
PG  - 198-208
AB  - Controversial and ethically tenuous, the use of placebos is central to medicine
      but even more pivotal to psychosocial therapies. Scholars, researchers, and
      practitioners largely disagree about the conceptualization of placebos. While
      different professionals often confound the meanings of placebo effects with
      placebo responses, physicians continue to prescribe placebos as part of clinical 
      practice. Our study aims to review attitudes and beliefs concerning placebos
      outside of clinical research. Herein we compare patterns of placebo use reported 
      by academic psychiatrists with those reported by physicians from different
      specialties across Canadian medical schools. Using a web-based tool, we
      circulated an online survey to all 17 Canadian medical schools, with a special
      emphasis on psychiatry departments therein and in university-affiliated teaching 
      hospitals. A variation on earlier efforts, our 5-minute, 21-question survey was
      anonymous. Among the 606 respondents who completed our online survey, 257 were
      psychiatrists. Our analysis revealed that psychiatrists prescribed significantly 
      more subtherapeutic doses of medication than physicians in other specialties,
      although about 20% of both psychiatrists and nonpsychiatrists prescribed placebos
      regularly as part of routine clinical practice. However, compared with 6% of
      nonpsychiatrists, only 2% of psychiatrists deemed placebos of no clinical
      benefit. In addition, more than 60% of psychiatrists either agreed or strongly
      agreed that placebos had therapeutic effects relative to fewer than 45% of other 
      practitioners. Findings from this pan-Canadian survey suggest that, compared with
      other physicians, psychiatrists seem to better value the influence placebos wield
      on the mind and body and maintain more favourable beliefs and attitudes toward
      placebo phenomena.
FAU - Raz, Amir
AU  - Raz A
AD  - Departments of Psychiatry, Neurology and Neuroscience, and Psychology, McGill
      University and the Jewish General Hospital, Montreal Neurological Institute,
      Montreal, Quebec. amir.raz@mcgill.ca
FAU - Campbell, Natasha
AU  - Campbell N
FAU - Guindi, Daniella
AU  - Guindi D
FAU - Holcroft, Christina
AU  - Holcroft C
FAU - Dery, Catherine
AU  - Dery C
FAU - Cukier, Olivia
AU  - Cukier O
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Can J Psychiatry
JT  - Canadian journal of psychiatry. Revue canadienne de psychiatrie
JID - 7904187
RN  - 0 (Placebos)
SB  - IM
CIN - Can J Psychiatry. 2011 Apr;56(4):191-2. PMID: 21507274
CIN - Can J Psychiatry. 2011 Sep;56(9):575; author reply 575-6. PMID: 21959033
CIN - Can J Psychiatry. 2011 Nov;56(11):703-4; author reply 704. PMID: 22114927
MH  - Attitude of Health Personnel
MH  - *Clinical Medicine/methods/standards
MH  - *Complementary Therapies/ethics/methods/standards
MH  - Culture
MH  - Data Collection
MH  - Ethics, Medical
MH  - General Practitioners/ethics/psychology
MH  - Health Services Research
MH  - Hospitals, University
MH  - Humans
MH  - *Placebo Effect
MH  - Placebos/*therapeutic use
MH  - *Practice Patterns, Physicians'/ethics/standards
MH  - Psychiatric Department, Hospital
MH  - *Psychiatry/ethics/methods/standards
MH  - Surveys and Questionnaires
EDAT- 2011/04/22 06:00
MHDA- 2011/08/17 06:00
CRDT- 2011/04/22 06:00
PHST- 2011/04/22 06:00 [entrez]
PHST- 2011/04/22 06:00 [pubmed]
PHST- 2011/08/17 06:00 [medline]
AID - 10.1177/070674371105600403 [doi]
PST - ppublish
SO  - Can J Psychiatry. 2011 Apr;56(4):198-208. doi: 10.1177/070674371105600403.


PMID- 21507273
OWN - NLM
STAT- MEDLINE
DCOM- 20110929
LR  - 20211020
IS  - 1472-6963 (Electronic)
IS  - 1472-6963 (Linking)
VI  - 11
DP  - 2011 Apr 21
TI  - Practicing provider-initiated HIV testing in high prevalence settings: consent
      concerns and missed preventive opportunities.
PG  - 87
LID - 10.1186/1472-6963-11-87 [doi]
AB  - BACKGROUND: Counselling is considered a prerequisite for the proper handling of
      testing and for ensuring effective HIV preventive efforts. HIV testing services
      have recently been scaled up substantially with a particular focus on
      provider-initiated models. Increasing HIV test rates have been attributed to the 
      rapid scale-up of the provider-initiated testing model, but there is limited
      documentation of experiences with this new service model. The aim of this study
      was to determine the use of different types of HIV testing services and to
      investigate perceptions and experiences of these services with a particular
      emphasis on the provider initiated testing in three selected districts in Kenya, 
      Tanzania, and, Zambia. METHODS: A concurrent triangulation mixed methods design
      was applied using quantitative and qualitative approaches. A population-based
      survey was conducted among adults in the three study districts, and qualitative
      data were obtained from 34 focus group discussions and 18 in-depth interviews.
      The data originates from the ongoing EU funded research project "REsponse to
      ACountable Priority Setting for Trust in Health Systems" (REACT) implemented in
      the three countries which has a research component linked to HIV and testing, and
      from an additional study focusing on HIV testing, counselling perceptions and
      experiences in Kenya. RESULTS: Proportions of the population formerly tested for 
      HIV differed sharply between the study districts and particularly among women
      (54% Malindi, 34% Kapiri Mposhi and 27% Mbarali) (p < 0.001). Women were much
      more likely to be tested than men in the districts that had scaled-up programmes 
      for preventing mother to child transmission of HIV (PMTCT). Only minor gender
      differences appeared for voluntary counselling and testing. In places where, the 
      provider-initiated model in PMTCT programmes had been rolled out extensively
      testing was accompanied by very limited pre- and post-test counselling and by a
      related neglect of preventative measures. Informants expressed frustration
      related to their experienced inability to 'opt-out' or decline from the
      provider-initiated HIV testing services. CONCLUSION: Counselling emerged as a
      highly valued process during HIV testing. However, counselling efforts were
      limited in the implementation of the provider-initiated opt-out HIV testing
      model. The approach was moreover not perceived as voluntary. This raises serious 
      ethical concerns and implies missed preventive opportunities inherent in the
      counselling concept. Moreover, implementation of the new testing approach seem to
      add a burden to pregnant women as disproportionate numbers of women get to know
      their HIV status, reveal their HIV status to their spouse and recruit their
      spouses to go for a test. We argue that there is an urgent need to reconsider the
      manner in which the provider initiated HIV testing model is implemented in order 
      to protect the client's autonomy and to maximise access to HIV prevention.
FAU - Njeru, Mercy K
AU  - Njeru MK
AD  - Centre for Public Health Research, Kenya Medical Research Institute, Nairobi,
      Kenya. mercy.njeru@cih.uib.no
FAU - Blystad, Astrid
AU  - Blystad A
FAU - Shayo, Elizabeth H
AU  - Shayo EH
FAU - Nyamongo, Isaac K
AU  - Nyamongo IK
FAU - Fylkesnes, Knut
AU  - Fylkesnes K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110421
PL  - England
TA  - BMC Health Serv Res
JT  - BMC health services research
JID - 101088677
SB  - IM
MH  - AIDS Serodiagnosis/*methods
MH  - Adolescent
MH  - Adult
MH  - Data Collection
MH  - Directive Counseling/*methods/statistics & numerical data
MH  - Female
MH  - Focus Groups
MH  - HIV Infections/*diagnosis/epidemiology/transmission
MH  - Health Education
MH  - Humans
MH  - Infectious Disease Transmission, Vertical/*prevention & control
MH  - Kenya/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Patient Education as Topic/*methods/statistics & numerical data
MH  - Pregnancy
MH  - Prevalence
MH  - Qualitative Research
MH  - Tanzania/epidemiology
MH  - Time Factors
MH  - Young Adult
MH  - Zambia/epidemiology
PMC - PMC3105945
EDAT- 2011/04/22 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/04/22 06:00
PHST- 2010/05/01 00:00 [received]
PHST- 2011/04/21 00:00 [accepted]
PHST- 2011/04/22 06:00 [entrez]
PHST- 2011/04/22 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - 1472-6963-11-87 [pii]
AID - 10.1186/1472-6963-11-87 [doi]
PST - epublish
SO  - BMC Health Serv Res. 2011 Apr 21;11:87. doi: 10.1186/1472-6963-11-87.


PMID- 21507237
OWN - NLM
STAT- MEDLINE
DCOM- 20110916
LR  - 20220331
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 12
DP  - 2011 Apr 20
TI  - Ethical issues posed by cluster randomized trials in health research.
PG  - 100
LID - 10.1186/1745-6215-12-100 [doi]
AB  - The cluster randomized trial (CRT) is used increasingly in knowledge translation 
      research, quality improvement research, community based intervention studies,
      public health research, and research in developing countries. However, cluster
      trials raise difficult ethical issues that challenge researchers, research ethics
      committees, regulators, and sponsors as they seek to fulfill responsibly their
      respective roles. Our project will provide a systematic analysis of the ethics of
      cluster trials. Here we have outlined a series of six areas of inquiry that must 
      be addressed if the cluster trial is to be set on a firm ethical foundation: 1.
      Who is a research subject? 2. From whom, how, and when must informed consent be
      obtained? 3. Does clinical equipoise apply to CRTs? 4. How do we determine if the
      benefits outweigh the risks of CRTs? 5. How ought vulnerable groups be protected 
      in CRTs? 6. Who are gatekeepers and what are their responsibilities? Subsequent
      papers in this series will address each of these areas, clarifying the ethical
      issues at stake and, where possible, arguing for a preferred solution. Our hope
      is that these papers will serve as the basis for the creation of international
      ethical guidelines for the design and conduct of cluster randomized trials.
FAU - Weijer, Charles
AU  - Weijer C
AD  - Rotman Institute of Philosophy, Department of Philosophy, University of Western
      Ontario, London, ON, N6A 5B8, Canada. cweijer@uwo.ca
FAU - Grimshaw, Jeremy M
AU  - Grimshaw JM
FAU - Taljaard, Monica
AU  - Taljaard M
FAU - Binik, Ariella
AU  - Binik A
FAU - Boruch, Robert
AU  - Boruch R
FAU - Brehaut, Jamie C
AU  - Brehaut JC
FAU - Donner, Allan
AU  - Donner A
FAU - Eccles, Martin P
AU  - Eccles MP
FAU - Gallo, Antonio
AU  - Gallo A
FAU - McRae, Andrew D
AU  - McRae AD
FAU - Saginur, Raphael
AU  - Saginur R
FAU - Zwarenstein, Merrick
AU  - Zwarenstein M
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Introductory Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110420
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
SB  - IM
CIN - Indian J Med Ethics. 2011 Oct-Dec;8(4):253-4. PMID: 22106673
MH  - *Cluster Analysis
MH  - *Data Interpretation, Statistical
MH  - *Ethics, Research
MH  - Evidence-Based Medicine/*ethics/statistics & numerical data
MH  - Humans
MH  - Informed Consent/ethics
MH  - Patient Rights/ethics
MH  - Patient Selection/ethics
MH  - Randomized Controlled Trials as Topic/*ethics/statistics & numerical data
MH  - Research Subjects
MH  - Risk Assessment
MH  - Therapeutic Equipoise
MH  - Vulnerable Populations
PMC - PMC3107798
EDAT- 2011/04/22 06:00
MHDA- 2011/09/17 06:00
CRDT- 2011/04/22 06:00
PHST- 2010/09/30 00:00 [received]
PHST- 2011/04/20 00:00 [accepted]
PHST- 2011/04/22 06:00 [entrez]
PHST- 2011/04/22 06:00 [pubmed]
PHST- 2011/09/17 06:00 [medline]
AID - 1745-6215-12-100 [pii]
AID - 10.1186/1745-6215-12-100 [doi]
PST - epublish
SO  - Trials. 2011 Apr 20;12:100. doi: 10.1186/1745-6215-12-100.


PMID- 21507103
OWN - NLM
STAT- MEDLINE
DCOM- 20110922
LR  - 20110421
IS  - 1365-2834 (Electronic)
IS  - 0966-0429 (Linking)
VI  - 19
IP  - 3
DP  - 2011 Apr
TI  - Brazilian registered nurses' perceptions and attitudes towards adverse events in 
      nursing care: a phenomenological study.
PG  - 331-8
LID - 10.1111/j.1365-2834.2011.01208.x [doi]
AB  - AIM: To describe the perceptions and attitudes of registered nurses (RNs) towards
      adverse events (AEs) in nursing care. BACKGROUND: The professionals' subjective
      perspectives should be taken into account for the prevention of AEs in care
      settings. METHOD: Schutz's social phenomenology was developed. Interviews were
      conducted with nine Intensive Care Unit RNs. RESULTS: The following five
      descriptive categories emerged: (1) the occurrence of AEs is inherent to the
      human condition but provokes a feeling of insecurity, (2) the occurrence of AEs
      indicates the existence of failures in health care systematization, (3) the
      professionals' attitudes towards AEs should be permeated by ethical principles;
      (4) the priority regarding AEs should be the mitigation of harm to patients, and 
      (5) decisions regarding the communication of AEs were determined by the severity 
      of the error. CONCLUSIONS: The various subjective perspectives related to the
      occurrence of AEs requires a health care systematization with a focus on
      prevention. Ethical behaviour is essential for the patients' safety. IMPLICATIONS
      FOR NURSING MANAGEMENT: Activities aimed at the prevention of AEs should be
      integrated jointly with both the professionals and the health care institution. A
      culture of safety, not punishment, and improvement in the quality of care
      provided to patients should be priorities.
CI  - (c) 2011 The Authors. Journal compilation (c) 2011 Blackwell Publishing Ltd.
FAU - De Freitas, Genival Fernandes
AU  - De Freitas GF
AD  - School of Nursing, University of Sao Paulo, Sao Paulo, Brazil. genivalf@usp.br
FAU - Hoga, Luiza Akiko Komura
AU  - Hoga LA
FAU - Fernandes, Maria de Fatima Prado
AU  - Fernandes Mde F
FAU - Gonzalez, Jose Siles
AU  - Gonzalez JS
FAU - Ruiz, Maria Carmen Solano
AU  - Ruiz MC
FAU - Bonini, Barbara Barrionuevo
AU  - Bonini BB
LA  - eng
PT  - Journal Article
DEP - 20110301
PL  - England
TA  - J Nurs Manag
JT  - Journal of nursing management
JID - 9306050
MH  - Accident Prevention/*methods
MH  - *Attitude of Health Personnel
MH  - Brazil
MH  - Delivery of Health Care
MH  - Humans
MH  - Intensive Care Units
MH  - Medical Errors/*nursing/prevention & control/psychology
MH  - Motivation
MH  - Nurses/*psychology
MH  - Nursing, Supervisory
MH  - *Perception
MH  - Psychological Theory
MH  - Qualitative Research
MH  - Tape Recording
EDAT- 2011/04/22 06:00
MHDA- 2011/09/23 06:00
CRDT- 2011/04/22 06:00
PHST- 2011/04/22 06:00 [entrez]
PHST- 2011/04/22 06:00 [pubmed]
PHST- 2011/09/23 06:00 [medline]
AID - 10.1111/j.1365-2834.2011.01208.x [doi]
PST - ppublish
SO  - J Nurs Manag. 2011 Apr;19(3):331-8. doi: 10.1111/j.1365-2834.2011.01208.x. Epub
      2011 Mar 1.


PMID- 21507100
OWN - NLM
STAT- MEDLINE
DCOM- 20110922
LR  - 20110421
IS  - 1365-2834 (Electronic)
IS  - 0966-0429 (Linking)
VI  - 19
IP  - 3
DP  - 2011 Apr
TI  - Reply to 'Civilizing the "Barbarian": a critical analysis of behaviour
      modification programmes in forensic psychiatry settings'.
PG  - 302-4
LID - 10.1111/j.1365-2834.2011.01259.x [doi]
AB  - AIM: To consider ethical propositions relating to nursing in UK forensic
      settings. BACKGROUND: A previous paper considered behavioural programmes with a
      Canadian forensic population. METHOD: Some literature and personal reflections
      are presented. RESULTS: Whilst some similarities with the nature of Canadian
      forensic settings are identified, the UK is developing its' own
      cognitive-behavioural tradition of working. CONCLUSIONS: The skills necessary for
      working with forensic patients are a development of a wider mental health nursing
      and therapy skill-set. IMPLICATIONS FOR NURSING MANAGEMENT: Nurse managers within
      forensic services need to be clear about the values of their services and ensure 
      that therapeutic approaches are consistent with these values. Managers must
      consider how to support nurses acquire the requisite skill-set.
CI  - (c) 2011 The Authors. Journal compilation (c) 2011 Blackwell Publishing Ltd.
FAU - Bowler, N
AU  - Bowler N
AD  - Advanced Clinical Practice (Mental Health Nursing), College of Human and Health
      Science, Swansea University, Swansea, UK. N.J.Bowler@swansea.ac.uk
FAU - Williams, M
AU  - Williams M
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - England
TA  - J Nurs Manag
JT  - Journal of nursing management
JID - 9306050
CON - J Nurs Manag. 2011 Apr;19(3):293-301. PMID: 21507099
MH  - *Ethics, Nursing
MH  - Forensic Nursing/*ethics
MH  - Forensic Psychiatry/*ethics
MH  - Humans
MH  - Nursing Evaluation Research/*methods
MH  - Nursing Research
MH  - Patient Care/ethics
MH  - Personal Autonomy
EDAT- 2011/04/22 06:00
MHDA- 2011/09/23 06:00
CRDT- 2011/04/22 06:00
PHST- 2011/04/22 06:00 [entrez]
PHST- 2011/04/22 06:00 [pubmed]
PHST- 2011/09/23 06:00 [medline]
AID - 10.1111/j.1365-2834.2011.01259.x [doi]
PST - ppublish
SO  - J Nurs Manag. 2011 Apr;19(3):302-4. doi: 10.1111/j.1365-2834.2011.01259.x.


PMID- 21507099
OWN - NLM
STAT- MEDLINE
DCOM- 20110922
LR  - 20220331
IS  - 1365-2834 (Electronic)
IS  - 0966-0429 (Linking)
VI  - 19
IP  - 3
DP  - 2011 Apr
TI  - Civilizing the 'Barbarian': a critical analysis of behaviour modification
      programmes in forensic psychiatry settings.
PG  - 293-301
LID - 10.1111/j.1365-2834.2011.01207.x [doi]
AB  - AIM: Drawing on the works of Erving Goffman and Michel Foucault, this article
      presents part of the results of a qualitative study conducted in a forensic
      psychiatry setting. BACKGROUND: For many years, behaviour modification programmes
      (BMPs) have been subjected to scrutiny and harsh criticism on the part of
      researchers, clinicians and professional organizations. Nevertheless, BMPs
      continue to be in vogue in some 'total' institutions, such as psychiatric
      hospitals and prisons. METHOD: Discourse analysis of mute evidence available in
      situ was used to critically look at behaviour modification programmes. RESULTS:
      Compelling examples of behaviour modification care plans are used to illustrate
      our critical analysis and to support our claim that BMPs violate both scientific 
      and ethical norms in the name of doing 'what is best' for the patients.
      CONCLUSION: We argue that the continued use of BMPs is not only flawed from a
      scientific perspective, but constitutes an unethical approach to the management
      of nursing care for mentally ill offenders. IMPLICATIONS FOR NURSING MANAGEMENT: 
      Nurse managers need to be aware that BMPs violate ethical standards in nursing.
      As a consequence, they should overtly question the use of these approaches in
      psychiatric nursing.
CI  - (c) 2011 The Authors. Journal compilation (c) 2011 Blackwell Publishing Ltd.
FAU - Holmes, Dave
AU  - Holmes D
AD  - School of Nursing, Faculty of Health Sciences, University of Ottawa, Ottawa, ON, 
      Canada. dholmes@uottawa.ca
FAU - Murray, Stuart J
AU  - Murray SJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110321
PL  - England
TA  - J Nurs Manag
JT  - Journal of nursing management
JID - 9306050
CIN - J Nurs Manag. 2011 Apr;19(3):302-4. PMID: 21507100
CIN - J Nurs Manag. 2012 Mar;20(2):296-7. PMID: 22380423
MH  - Behavior Therapy/*methods
MH  - *Ethics, Nursing
MH  - Forensic Nursing/*methods
MH  - Forensic Psychiatry/*methods
MH  - Humans
MH  - Nursing Evaluation Research/*methods
MH  - Nursing Research
MH  - Patient Care/ethics
MH  - Personal Autonomy
MH  - Qualitative Research
EDAT- 2011/04/22 06:00
MHDA- 2011/09/23 06:00
CRDT- 2011/04/22 06:00
PHST- 2011/04/22 06:00 [entrez]
PHST- 2011/04/22 06:00 [pubmed]
PHST- 2011/09/23 06:00 [medline]
AID - 10.1111/j.1365-2834.2011.01207.x [doi]
PST - ppublish
SO  - J Nurs Manag. 2011 Apr;19(3):293-301. doi: 10.1111/j.1365-2834.2011.01207.x. Epub
      2011 Mar 21.


PMID- 21507012
OWN - NLM
STAT- MEDLINE
DCOM- 20120227
LR  - 20161125
IS  - 1467-9566 (Electronic)
IS  - 0141-9889 (Linking)
VI  - 33
IP  - 7
DP  - 2011 Nov
TI  - Enterprising or altruistic selves? Making up research subjects in genetics
      research.
PG  - 1081-95
LID - 10.1111/j.1467-9566.2011.01348.x [doi]
AB  - The emergence of direct-to-consumer (DTC) personal genomics companies in 2007 was
      accompanied by considerable media attention and criticism from clinical
      geneticists and other health professionals, regulators, policy advisors, and
      ethicists. As well as offering genetic testing services, some firms are also
      engaged in building their own databases and conducting research with the data
      obtained from their customers. In this paper, we examine how one of these
      companies, 23andMe, is creating a certain kind of 'research subject' in
      opposition to that constituted in conventional forms of disease research. Drawing
      on debates about neoliberalism, contemporary health discourses and subjectivity, 
      we consider two kinds of subjectivities produced through the discursive and
      material practices of 23andMe and UK Biobank, namely, 'enterprising' and
      'altruistic' selves. We argue that the 23andMe model promotes the idea that
      curiosity about one's genome on the one hand, and participation in research on
      the other, are not only compatible but complementary aspects of being an
      entrepreneurial subject of contemporary health and medicine framed by the
      technologies of web 2.0.
CI  - (c) 2011 The Authors. Sociology of Health & Illness (c) 2011 Foundation for the
      Sociology of Health & Illness/Blackwell Publishing Ltd.
FAU - Tutton, Richard
AU  - Tutton R
AD  - ESRC Centre for Economic and Social Aspects of Genomics (Cesagen), Department of 
      Sociology, Lancaster University. r.tutton@lancaster.ac.uk
FAU - Prainsack, Barbara
AU  - Prainsack B
LA  - eng
PT  - Journal Article
DEP - 20110420
PL  - England
TA  - Sociol Health Illn
JT  - Sociology of health & illness
JID - 8205036
RN  - 0 (Genetic Markers)
SB  - IM
MH  - *Altruism
MH  - Biomedical Research/*ethics
MH  - Decision Making
MH  - *Ethics, Research
MH  - Genetic Markers
MH  - Genetic Research/*ethics
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Internet
MH  - Metagenomics/ethics
MH  - *Motivation
MH  - Patient Selection/*ethics
MH  - Surveys and Questionnaires
MH  - United Kingdom
EDAT- 2011/04/22 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/04/22 06:00
PHST- 2011/04/22 06:00 [entrez]
PHST- 2011/04/22 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - 10.1111/j.1467-9566.2011.01348.x [doi]
PST - ppublish
SO  - Sociol Health Illn. 2011 Nov;33(7):1081-95. doi:
      10.1111/j.1467-9566.2011.01348.x. Epub 2011 Apr 20.


PMID- 21506689
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20110701
IS  - 1748-6963 (Electronic)
IS  - 1743-5889 (Linking)
VI  - 6
IP  - 4
DP  - 2011 Jun
TI  - Scientists' perception of ethical issues in nanomedicine: a case study.
PG  - 681-91
LID - 10.2217/nnm.11.9 [doi]
AB  - AIM: Research and development in nanomedicine has been accompanied by the
      consideration of ethical issues; however, little is known about how researchers
      working in this area perceive such issues. This case-study explores scientists'
      attitude towards and knowledge of ethical issues. METHOD: Data were collected by 
      semi-structured interviews with 22 nanomedicine practitioners and subject to
      content analysis. RESULTS: We found that scientists reflect with ambiguity on the
      reputed novelty of nanomedicine and what the ethical issues and risks are in
      their work. Respondents see no necessity for a paradigm shift in ethical
      considerations, but view ethical issues in nanomedicine as overlapping with those
      of other areas of biomedical research. Most respondents discuss ethical issues
      they faced in scientific work with their colleagues, but expect benefit from
      additional information and training on ethics. CONCLUSION: Our findings that
      scientists are motivated to reflect on ethical issues in their work, can
      contribute to the design of new strategies, including training programs, to
      engage scientists in ethical discussion and stimulate their responsibility as
      nanomedicine practitioners.
FAU - Silva Costa, Helena
AU  - Silva Costa H
AD  - Instituto de Biologia Molecular e Celular, Universidade do Porto, Rua do Campo
      Alegre, 823, 4150-180 Porto, Portugal. helena.costa@kit.edu
FAU - Sethe, Sebastian
AU  - Sethe S
FAU - Pego, Ana P
AU  - Pego AP
FAU - Olsson, I Anna S
AU  - Olsson IA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110420
PL  - England
TA  - Nanomedicine (Lond)
JT  - Nanomedicine (London, England)
JID - 101278111
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Models, Theoretical
MH  - Nanomedicine/*ethics/*methods
MH  - Nanotechnology
MH  - Perception
MH  - Research Personnel/*psychology
MH  - Young Adult
EDAT- 2011/04/22 06:00
MHDA- 2011/10/25 06:00
CRDT- 2011/04/22 06:00
PHST- 2011/04/22 06:00 [entrez]
PHST- 2011/04/22 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
AID - 10.2217/nnm.11.9 [doi]
PST - ppublish
SO  - Nanomedicine (Lond). 2011 Jun;6(4):681-91. doi: 10.2217/nnm.11.9. Epub 2011 Apr
      20.


PMID- 21483419
OWN - NLM
STAT- MEDLINE
DCOM- 20110519
LR  - 20151119
IS  - 1476-5497 (Electronic)
IS  - 0307-0565 (Linking)
VI  - 35 Suppl 1
DP  - 2011 Apr
TI  - The ethics of evaluating obesity intervention studies on children.
PG  - S24-9
LID - 10.1038/ijo.2011.32 [doi]
AB  - The methodology of the IDEFICS (Identification and prevention of dietary- and
      lifestyle-induced health effects in children and infants) study raises a number
      of important ethical questions. Many of these are already well recognised in
      ethical guidelines that uphold principles of individual and parental consent,
      confidentiality and scientific review. There are, however, wider issues that
      require ethical reflection. In this paper, we focus on a set of problems
      surrounding the evaluation of complex social interventions, and argue that
      comprehensive and objective evaluation is a much more ethically charged aim than 
      it may first appear. In particular, we contend that standard scientific
      measures-of body size and biomarkers-convey only part of the story. This is
      partly because, when we intervene in communities, we are also concerned with
      complex social effects. These effects are made even more complex by contemporary 
      social anxieties about fat and physical appearance, as well as about the safety
      and security of children. Such anxieties increase the risk of undesirable side
      effects that are themselves difficult to gauge. In the face of these and other
      complexities, we argue that the evaluation of interventions should involve a
      strong ethical dimension. First, it must include-as does the IDEFICS
      study-consideration of the opinions of the people affected, who are subjected to 
      interventions in ways that necessarily go beyond individual consent. Second, we
      suggest that interventions might also be assessed by how much they empower
      people-and especially those persons, such as children, who are otherwise often
      disempowered.
FAU - Wickins-Drazilova, D
AU  - Wickins-Drazilova D
AD  - Department of Politics, Philosophy and Religion, Lancaster University, UK.
      d.wickins-drazilova@lancaster.ac.uk
FAU - Williams, G
AU  - Williams G
CN  - IDEFICS Consortium
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Obes (Lond)
JT  - International journal of obesity (2005)
JID - 101256108
RN  - 0 (Biomarkers)
SB  - IM
MH  - *Bioethical Issues
MH  - Biomarkers/analysis
MH  - Body Size
MH  - Child
MH  - Child, Preschool
MH  - *Diet
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Infant
MH  - Life Style
MH  - Male
MH  - Obesity/*prevention & control
MH  - Parents
MH  - Preventive Health Services/*ethics/standards
EDAT- 2011/04/22 06:00
MHDA- 2011/05/20 06:00
CRDT- 2011/04/13 06:00
PHST- 2011/04/13 06:00 [entrez]
PHST- 2011/04/22 06:00 [pubmed]
PHST- 2011/05/20 06:00 [medline]
AID - ijo201132 [pii]
AID - 10.1038/ijo.2011.32 [doi]
PST - ppublish
SO  - Int J Obes (Lond). 2011 Apr;35 Suppl 1:S24-9. doi: 10.1038/ijo.2011.32.


PMID- 21481047
OWN - NLM
STAT- MEDLINE
DCOM- 20110527
LR  - 20211020
IS  - 1365-2184 (Electronic)
IS  - 0960-7722 (Linking)
VI  - 44 Suppl 1
DP  - 2011 Apr
TI  - From embryonic stem cells to iPS - an ethical perspective.
PG  - 70-84
LID - 10.1111/j.1365-2184.2010.00723.x [doi]
FAU - Suaudeau, J
AU  - Suaudeau J
AD  - Pontifical Academy for Life, Rome, Italy. jsuaudeau@pav.va
LA  - eng
PT  - Journal Article
PL  - England
TA  - Cell Prolif
JT  - Cell proliferation
JID - 9105195
SB  - IM
MH  - Embryonic Stem Cells/*cytology/metabolism
MH  - Humans
MH  - Stem Cell Research/*ethics
PMC - PMC6496856
EDAT- 2011/04/22 06:00
MHDA- 2011/05/28 06:00
CRDT- 2011/04/13 06:00
PHST- 2011/04/13 06:00 [entrez]
PHST- 2011/04/22 06:00 [pubmed]
PHST- 2011/05/28 06:00 [medline]
AID - 10.1111/j.1365-2184.2010.00723.x [doi]
PST - ppublish
SO  - Cell Prolif. 2011 Apr;44 Suppl 1:70-84. doi: 10.1111/j.1365-2184.2010.00723.x.


PMID- 21481046
OWN - NLM
STAT- MEDLINE
DCOM- 20110527
LR  - 20211020
IS  - 1365-2184 (Electronic)
IS  - 0960-7722 (Linking)
VI  - 44 Suppl 1
DP  - 2011 Apr
TI  - The umbilical cord: a rich and ethical stem cell source to advance regenerative
      medicine.
PG  - 60-9
LID - 10.1111/j.1365-2184.2010.00729.x [doi]
AB  - Science and medicine place a lot of hope in the development of stem cell research
      and regenerative medicine. This review will define the concept of regenerative
      medicine and focus on an abundant stem cell source - neonatal tissues such as the
      umbilical cord. Umbilical cord blood has been used clinically for over 20 years
      as a cell source for haematopoietic stem cell transplantation. Beyond this, cord 
      blood and umbilical cord-derived stem cells have demonstrated potential for
      pluripotent lineage differentiation (liver, pancreatic, neural tissues and more) 
      in vitro and in vivo. This promising research has opened up a new era for
      utilization of neonatal stem cells, now used beyond haematology in clinical
      trials for autoimmune disorders, cerebral palsy or type I diabetes.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Forraz, N
AU  - Forraz N
AD  - CTI-LYON, Cell Therapy Research Institute, Parc Technologique de Lyon St Priest, 
      France.
FAU - McGuckin, C P
AU  - McGuckin CP
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Cell Prolif
JT  - Cell proliferation
JID - 9105195
SB  - IM
MH  - Animals
MH  - Fetal Blood/*cytology
MH  - Humans
MH  - Regenerative Medicine/*trends
MH  - Stem Cell Research
MH  - Stem Cells/*cytology
PMC - PMC6495455
EDAT- 2011/04/22 06:00
MHDA- 2011/05/28 06:00
CRDT- 2011/04/13 06:00
PHST- 2011/04/13 06:00 [entrez]
PHST- 2011/04/22 06:00 [pubmed]
PHST- 2011/05/28 06:00 [medline]
AID - 10.1111/j.1365-2184.2010.00729.x [doi]
PST - ppublish
SO  - Cell Prolif. 2011 Apr;44 Suppl 1:60-9. doi: 10.1111/j.1365-2184.2010.00729.x.


PMID- 21506243
OWN - NLM
STAT- MEDLINE
DCOM- 20110914
LR  - 20110420
IS  - 1527-6473 (Electronic)
IS  - 1527-6465 (Linking)
VI  - 17
IP  - 5
DP  - 2011 May
TI  - Utilization of elderly donors in living donor liver transplantation: when more is
      less?
PG  - 548-55
LID - 10.1002/lt.22276 [doi]
AB  - An accepted definition of donor exclusion criteria has not been established for
      living donor liver transplantation (LDLT). The use of elderly donors to expand
      the living donor pool raises ethical concerns about donor safety. The aims of
      this study were (1) the comparison of the postoperative outcomes of living liver 
      donors by age (>/= 50 versus < 50 years) and (2) the evaluation of the impact of 
      the extent of right hepatectomy on donor outcomes. The study group included 150
      donors who underwent donor right hepatectomy between October 2004 and April 2009.
      Extended criteria surgery (ECS) was defined as right hepatectomy with middle
      hepatic vein (MHV) harvesting or right hepatectomy resulting in an estimated
      remnant liver volume (RLV) less than 35%. The primary endpoints were donor
      outcomes in terms of donor complications graded according to the Clavien
      classification. Group 1 consisted of donors who were 50 years old or older (n =
      28), and group 2 consisted of donors who were less than 50 years old (n = 122).
      At least 1 ECS criterion was present in 74% of donors: 57% had 1 criterion, and
      17% had 2 criteria. None of the donors had grade 4 complications or died. The
      overall and major complication rates were similar in the 2 donor age groups
      [28.6% and 14.3% in group 1 and 32% and 8.2% in group 2 for the overall
      complication rates (P = 0.8) and the major complication rates (P = 0.2),
      respectively]. However, there was a significant correlation between the rate of
      major complications and the type of surgery in donors who were 50 years old or
      older. In LDLT, extending the limits of surgery comes at the price of more
      complications in elderly donors. Right hepatectomy with MHV harvesting and any
      procedure causing an RLV less than 35% should be avoided in living liver donors
      who are 50 years old or older.
CI  - Copyright (c) 2011 American Association for the Study of Liver Diseases.
FAU - Dayangac, Murat
AU  - Dayangac M
AD  - Center for Organ Transplantation, Florence Nightingale Hospital, Istanbul,
      Turkey.
FAU - Taner, C Burcin
AU  - Taner CB
FAU - Yaprak, Onur
AU  - Yaprak O
FAU - Demirbas, Tolga
AU  - Demirbas T
FAU - Balci, Deniz
AU  - Balci D
FAU - Duran, Cihan
AU  - Duran C
FAU - Yuzer, Yildiray
AU  - Yuzer Y
FAU - Tokat, Yaman
AU  - Tokat Y
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Liver Transpl
JT  - Liver transplantation : official publication of the American Association for the 
      Study of Liver Diseases and the International Liver Transplantation Society
JID - 100909185
SB  - IM
CIN - Liver Transpl. 2011 May;17(5):494-5. PMID: 21360647
CIN - Nat Rev Gastroenterol Hepatol. 2011 May;8(5):251-2. PMID: 21468122
MH  - Adult
MH  - *Age Factors
MH  - Biopsy
MH  - Donor Selection
MH  - Female
MH  - Hepatectomy/methods
MH  - Humans
MH  - Liver/surgery
MH  - Liver Transplantation/*methods
MH  - Living Donors
MH  - Male
MH  - Middle Aged
MH  - Postoperative Complications/surgery
MH  - Postoperative Period
MH  - Tissue and Organ Harvesting
MH  - Tissue and Organ Procurement/*methods
MH  - Treatment Outcome
EDAT- 2011/04/21 06:00
MHDA- 2011/09/15 06:00
CRDT- 2011/04/21 06:00
PHST- 2011/04/21 06:00 [entrez]
PHST- 2011/04/21 06:00 [pubmed]
PHST- 2011/09/15 06:00 [medline]
AID - 10.1002/lt.22276 [doi]
PST - ppublish
SO  - Liver Transpl. 2011 May;17(5):548-55. doi: 10.1002/lt.22276.


PMID- 21505137
OWN - NLM
STAT- MEDLINE
DCOM- 20110421
LR  - 20161017
IS  - 1538-3598 (Electronic)
IS  - 0098-7484 (Linking)
VI  - 305
IP  - 15
DP  - 2011 Apr 20
TI  - How to enroll participants in research ethically.
PG  - 1587-8
LID - 10.1001/jama.2011.421 [doi]
FAU - Wendler, David
AU  - Wendler D
AD  - Department of Bioethics, National Institutes of Health Clinical Center, Bethesda,
      Maryland 20892, USA. dwendler@nih.gov
LA  - eng
PT  - Journal Article
PL  - United States
TA  - JAMA
JT  - JAMA
JID - 7501160
SB  - IM
CIN - JAMA. 2011 Jul 20;306(3):266; author reply 266. PMID: 21771984
MH  - Biomedical Research/ethics
MH  - Comprehension
MH  - Decision Making
MH  - Humans
MH  - Informed Consent/*ethics/*standards
MH  - Jurisprudence
MH  - Mental Competency
MH  - Patient Selection/*ethics
EDAT- 2011/04/21 06:00
MHDA- 2011/04/22 06:00
CRDT- 2011/04/21 06:00
PHST- 2011/04/21 06:00 [entrez]
PHST- 2011/04/21 06:00 [pubmed]
PHST- 2011/04/22 06:00 [medline]
AID - 305/15/1587 [pii]
AID - 10.1001/jama.2011.421 [doi]
PST - ppublish
SO  - JAMA. 2011 Apr 20;305(15):1587-8. doi: 10.1001/jama.2011.421.


PMID- 21505086
OWN - NLM
STAT- MEDLINE
DCOM- 20120727
LR  - 20131121
IS  - 1552-4604 (Electronic)
IS  - 0091-2700 (Linking)
VI  - 52
IP  - 4
DP  - 2012 Apr
TI  - Cost of adverse drug reactions in a South Indian tertiary care teaching hospital.
PG  - 559-65
LID - 10.1177/0091270011398867 [doi]
AB  - In India, very few reports on the cost of adverse drug reactions (ADRs) are
      available. There is a need to study this aspect of health care in order to
      understand the economic burden imposed by ADRs. The aim of the current work was
      to study the costs associated with documented ADRs in a tertiary care teaching
      hospital. This study was conducted in medical wards of a south Indian tertiary
      care teaching hospital over a 6-month period. The study protocol was assessed and
      approved by the institutional ethics committee. A total of 317 ADRs from 246
      patients were identified during the study period. The present study used an
      intensive monitoring method to detect ADRs and assessed an incidence of 32.7%
      adverse reactions in the monitored group. The causality, severity,
      predictability, and preventability of the documented ADRs were assessed. The
      total cost to the hospital due to ADRs was found to be Rs. 1,567,397 (US$36 451).
      The average cost per patient hospitalized with an ADR was Rs. 4,945 (US$115). The
      cost per reaction was found to be higher in the Indian context, as the per capita
      annual expenditure on health in this country is around US$109.
FAU - Rajakannan, Thiyagu
AU  - Rajakannan T
AD  - Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences,
      Manipal University, Manipal, India. rthiyagu82@gmail.com
FAU - Mallayasamy, Surulivelrajan
AU  - Mallayasamy S
FAU - Guddattu, Vasudeva
AU  - Guddattu V
FAU - Kamath, Asha
AU  - Kamath A
FAU - Vilakkthala, Rajesh
AU  - Vilakkthala R
FAU - Rao, Padma G M
AU  - Rao PG
FAU - Bairy, Laxminarayana K
AU  - Bairy LK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110419
PL  - England
TA  - J Clin Pharmacol
JT  - Journal of clinical pharmacology
JID - 0366372
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Drug Monitoring
MH  - *Drug-Related Side Effects and Adverse Reactions/*economics
MH  - Female
MH  - Hospital Costs/*statistics & numerical data
MH  - Hospitals, Teaching/*economics/statistics & numerical data
MH  - Humans
MH  - Incidence
MH  - India
MH  - Male
MH  - Middle Aged
MH  - Pharmaceutical Preparations/economics
MH  - Severity of Illness Index
MH  - Young Adult
EDAT- 2011/04/21 06:00
MHDA- 2012/07/28 06:00
CRDT- 2011/04/21 06:00
PHST- 2011/04/21 06:00 [entrez]
PHST- 2011/04/21 06:00 [pubmed]
PHST- 2012/07/28 06:00 [medline]
AID - 0091270011398867 [pii]
AID - 10.1177/0091270011398867 [doi]
PST - ppublish
SO  - J Clin Pharmacol. 2012 Apr;52(4):559-65. doi: 10.1177/0091270011398867. Epub 2011
      Apr 19.


PMID- 21504798
OWN - NLM
STAT- MEDLINE
DCOM- 20111007
LR  - 20181201
IS  - 1878-5832 (Electronic)
IS  - 1359-6446 (Linking)
VI  - 16
IP  - 11-12
DP  - 2011 Jun
TI  - Drug discovery management, small is still beautiful: Why a number of companies
      get it wrong.
PG  - 476-84
LID - 10.1016/j.drudis.2011.04.002 [doi]
AB  - This review provides an account of why more companies involved in drug discovery 
      fail than succeed at releasing the creative energy of gifted scientists, whose
      invention of new drugs they rely upon to remain at the forefront of the biopharma
      industry. Initiatives aimed at improving output of new chemical entities often
      have the opposite effect from that intended and scientists become demotivated.
      Those with drive, vision and enthusiasm may move to smaller companies to
      rediscover the spirit of discovery. Some executives fail to understand the psyche
      of researchers; an applied understanding of the intrinsic motivation of
      scientists would improve research performance. Entities that focus on smaller
      autonomous units and sound ethical values will discover the most innovative and
      successful new drugs.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Knutsen, Lars J S
AU  - Knutsen LJ
AD  - Discovery Pharma Consulting LLC, West Chester, PA 19382, USA.
      lars@discoverypharm.com
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110409
PL  - England
TA  - Drug Discov Today
JT  - Drug discovery today
JID - 9604391
SB  - IM
MH  - Drug Discovery/*organization & administration/trends
MH  - Drug Industry/*organization & administration/trends
MH  - Motivation
MH  - Organizational Innovation
MH  - Organizational Objectives
MH  - *Research Personnel/psychology
MH  - Workforce
MH  - *Workplace/organization & administration/psychology
EDAT- 2011/04/21 06:00
MHDA- 2011/10/08 06:00
CRDT- 2011/04/21 06:00
PHST- 2010/07/06 00:00 [received]
PHST- 2011/02/23 00:00 [revised]
PHST- 2011/04/01 00:00 [accepted]
PHST- 2011/04/21 06:00 [entrez]
PHST- 2011/04/21 06:00 [pubmed]
PHST- 2011/10/08 06:00 [medline]
AID - S1359-6446(11)00108-5 [pii]
AID - 10.1016/j.drudis.2011.04.002 [doi]
PST - ppublish
SO  - Drug Discov Today. 2011 Jun;16(11-12):476-84. doi: 10.1016/j.drudis.2011.04.002. 
      Epub 2011 Apr 9.


PMID- 21503811
OWN - NLM
STAT- MEDLINE
DCOM- 20120419
LR  - 20211020
IS  - 1573-6571 (Electronic)
IS  - 0022-4197 (Linking)
VI  - 50
IP  - 4
DP  - 2011 Dec
TI  - Surrogate motherhood revisited: maternal identity from a Jewish perspective.
PG  - 835-40
LID - 10.1007/s10943-011-9494-4 [doi]
AB  - A new bill regulating ovum donation in Israel is set to pass its second and third
      readings in the Israel Parliament in the upcoming months. The new law will expand
      the number of locally donated ova available, as previously Israeli women were
      prohibited from donating eggs unless they were undergoing fertility treatment.
      Parallel to this legislative initiative, there has been a change in rabbinical
      thinking over who is considered the mother in a case of surrogacy. Previously,
      the consensus has been that the birth mother is to be considered the mother, but 
      over the last few years there has been a change in thinking and the genetic
      mother is now considered the mother. The purpose of this paper is to present the 
      ethical and legal issues from a Jewish perspective in determining maternal
      identity. The dilemma also demonstrates some of the difficulties in applying
      Talmudic law to modern problems and the various methodologies used to overcome
      these issues.
FAU - Jotkowitz, Alan
AU  - Jotkowitz A
AD  - The Jakobovits Center for Jewish Medical Ethics, Faculty of Health Sciences,
      Ben-Gurion University of the Negev, Beer-Sheva, Israel. ajotkowitz@hotmail.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Relig Health
JT  - Journal of religion and health
JID - 2985199R
SB  - IM
MH  - Adult
MH  - Attitude to Health/ethnology
MH  - Female
MH  - Fertilization in Vitro/*legislation & jurisprudence
MH  - Government Regulation
MH  - Health Behavior/ethnology
MH  - Humans
MH  - Infertility, Female/therapy
MH  - Interpersonal Relations
MH  - Israel
MH  - Jews
MH  - *Judaism
MH  - Maternal Welfare/*legislation & jurisprudence
MH  - Patient Advocacy/*legislation & jurisprudence
MH  - Pregnancy
MH  - Social Isolation
MH  - Surrogate Mothers/*legislation & jurisprudence/psychology
MH  - Tissue Donors
MH  - Women's Health/*legislation & jurisprudence
MH  - Young Adult
EDAT- 2011/04/20 06:00
MHDA- 2012/04/20 06:00
CRDT- 2011/04/20 06:00
PHST- 2011/04/20 06:00 [entrez]
PHST- 2011/04/20 06:00 [pubmed]
PHST- 2012/04/20 06:00 [medline]
AID - 10.1007/s10943-011-9494-4 [doi]
PST - ppublish
SO  - J Relig Health. 2011 Dec;50(4):835-40. doi: 10.1007/s10943-011-9494-4.


PMID- 21503596
OWN - NLM
STAT- MEDLINE
DCOM- 20111219
LR  - 20211020
IS  - 1534-6269 (Electronic)
IS  - 1523-3790 (Linking)
VI  - 13
IP  - 4
DP  - 2011 Aug
TI  - The challenges of providing palliative care for older people with dementia.
PG  - 295-301
LID - 10.1007/s11912-011-0171-2 [doi]
AB  - Palliative care seems the right approach to dementia, except that it suggests a
      dichotomy between cure and care. As in cancer care, supportive care provides a
      broader framework, viewing dementia from the time of diagnosis until death and
      bereavement. The challenge is to find the right approach to the individual. This 
      challenge arises in the person's own home, in long-term care homes, and in
      hospitals. The challenging features of palliative care for older people with
      dementia are found in connection with the use of antibiotics, antipsychotics, and
      other medications, as well as in decisions about whether the person is in pain or
      in distress, or whether artificial feeding should be contemplated or not, as well
      as about the use of advance care plans. In short, the challenges are essentially 
      ethical as well as clinical. The right approach will be the one that recognizes
      this facet of clinical care.
FAU - Kupper, Anita-Luise
AU  - Kupper AL
AD  - Northumberland, Tyne and Wear NHS Foundation Trust, Older People's Services, St. 
      George's Park, Morpeth, NE61 2NU, UK. Anita-Luise.Kupper@ntw.nhs.uk
FAU - Hughes, Julian C
AU  - Hughes JC
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Oncol Rep
JT  - Current oncology reports
JID - 100888967
RN  - 0 (Antipsychotic Agents)
SB  - IM
MH  - Advance Care Planning
MH  - Aged
MH  - Antipsychotic Agents/administration & dosage
MH  - Dementia/diagnosis/*therapy
MH  - Humans
MH  - Nutritional Support
MH  - Pain Management
MH  - *Palliative Care
EDAT- 2011/04/20 06:00
MHDA- 2011/12/20 06:00
CRDT- 2011/04/20 06:00
PHST- 2011/04/20 06:00 [entrez]
PHST- 2011/04/20 06:00 [pubmed]
PHST- 2011/12/20 06:00 [medline]
AID - 10.1007/s11912-011-0171-2 [doi]
PST - ppublish
SO  - Curr Oncol Rep. 2011 Aug;13(4):295-301. doi: 10.1007/s11912-011-0171-2.


PMID- 21502430
OWN - NLM
STAT- MEDLINE
DCOM- 20110617
LR  - 20191210
IS  - 1943-7722 (Electronic)
IS  - 0002-9173 (Linking)
VI  - 135
IP  - 5
DP  - 2011 May
TI  - Pathology archive: evaluation of integrity, regulatory compliance, and
      construction of searchable database from print reports.
PG  - 753-9
LID - 10.1309/AJCP3CVA2NAVUUVU [doi]
AB  - Tissue repositories maintained by pathology departments represent an abundant
      resource of clinically annotated human specimens. The storage expenses associated
      with pathology archives are known to administrators of most pathology
      departments. However, such basic repository characteristics as the quality of
      stored materials, ease of access, and search and retrieval rates are often
      unclear. The aims of our work were to design a framework to assess the quality of
      a historic pathology archive, to propose the definition of "archive integrity,"
      and to provide benchmarks for tissue block retrieval rates and DNA integrity. We 
      share our experience with scanning approximately 120,000 pathology reports from
      1956 to 1979 into an electronically searchable archive, with a $9,000 budget,
      completed in 6 weeks. Several ethical and legal considerations that shaped the
      technical side of this project are discussed.
FAU - Smith, Matthew A
AU  - Smith MA
AD  - Department of Pathology, University of Pittsburgh Medical Center, PA 15261, USA.
FAU - Barnes, E Leon
AU  - Barnes EL
FAU - Chiosea, Simion I
AU  - Chiosea SI
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - *Archives
MH  - DNA/analysis
MH  - *Databases, Factual/ethics/legislation & jurisprudence/standards
MH  - Humans
MH  - *Pathology
EDAT- 2011/04/20 06:00
MHDA- 2011/06/18 06:00
CRDT- 2011/04/20 06:00
PHST- 2011/04/20 06:00 [entrez]
PHST- 2011/04/20 06:00 [pubmed]
PHST- 2011/06/18 06:00 [medline]
AID - 135/5/753 [pii]
AID - 10.1309/AJCP3CVA2NAVUUVU [doi]
PST - ppublish
SO  - Am J Clin Pathol. 2011 May;135(5):753-9. doi: 10.1309/AJCP3CVA2NAVUUVU.


PMID- 21502385
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20110722
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 260
IP  - 2
DP  - 2011 Aug
TI  - Assessing signal intensity change on well-registered images: comparing
      subtraction, color-encoded subtraction, and parallel display formats.
PG  - 400-7
LID - 10.1148/radiol.11101092 [doi]
AB  - PURPOSE: To assess the sensitivity, specificity, accuracy, and interobserver
      reliability of subtraction, color-encoded subtraction, and parallel display
      formats in assessing signal intensity (SI) differences between well-registered
      images. MATERIALS AND METHODS: Institutional ethics approval for the study and a 
      waiver of individual patient consent were obtained. Five radiologists graded the 
      severity of fatty liver by using a seven-point scale for four imaging sets
      created from 179 pairs of dual-echo in- and opposed-phase magnetic resonance
      images from 179 patients. The four sets contained images displayed in parallel,
      subtraction images, color-encoded subtraction images, and images from the three
      previous formats presented together. The order of the images and sets was
      randomized. Sensitivity and specificity were assessed with the McNemar test.
      Accuracy was assessed by using three-way analysis of variance, with Tukey post
      hoc methods used to assess differences between the four formats. Interobserver
      reliability was assessed by using the Fleiss kappa value. RESULTS: Subtraction (P
      = .016 at a 5% SI difference threshold) and color-encoded subtraction (P = .031
      at a 4% SI difference threshold) formats had higher sensitivity than did the
      parallel format. The accuracy of the subtraction format was superior to that of
      the parallel format (P < .0001). Interobserver reliability of the subtraction
      (kappa = 0.53) and color-encoded subtraction (kappa = 0.39) formats was superior 
      to that of the parallel format (kappa = 0.33) (P < .0001 and P = .0085,
      respectively). CONCLUSION: When images are well registered, subtraction and
      color-encoded subtraction techniques offer advantages over the traditional
      parallel presentation format for the assessment of SI differences.
CI  - (c) RSNA, 2011.
FAU - Tay, Kevin L
AU  - Tay KL
AD  - Department of Radiology, Royal Melbourne Hospital, Parkville, Australia.
      ktay8280@mail.usyd.edu.au
FAU - Yang, Jessica L
AU  - Yang JL
FAU - Phal, Pramit M
AU  - Phal PM
FAU - Lim, Beng Ghee
AU  - Lim BG
FAU - Pascoe, Diane M
AU  - Pascoe DM
FAU - Stella, Damien L
AU  - Stella DL
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110418
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Analysis of Variance
MH  - Child
MH  - Fatty Liver/*pathology
MH  - Female
MH  - Humans
MH  - Image Enhancement/methods
MH  - Image Interpretation, Computer-Assisted
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Signal Processing, Computer-Assisted
MH  - Subtraction Technique
EDAT- 2011/04/20 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/04/20 06:00
PHST- 2011/04/20 06:00 [entrez]
PHST- 2011/04/20 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - radiol.11101092 [pii]
AID - 10.1148/radiol.11101092 [doi]
PST - ppublish
SO  - Radiology. 2011 Aug;260(2):400-7. doi: 10.1148/radiol.11101092. Epub 2011 Apr 18.


PMID- 21502383
OWN - NLM
STAT- MEDLINE
DCOM- 20110902
LR  - 20151119
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 260
IP  - 1
DP  - 2011 Jul
TI  - Use of dynamic contrast-enhanced MR imaging to predict survival in patients with 
      primary breast cancer undergoing neoadjuvant chemotherapy.
PG  - 68-78
LID - 10.1148/radiol.11102493 [doi]
AB  - PURPOSE: To investigate whether early changes in vascular parameters determined
      with dynamic contrast material-enhanced magnetic resonance (MR) imaging after two
      cycles of neoadjuvant chemotherapy (NAC) are predictive of disease-free and
      overall survival in primary breast cancer. MATERIALS AND METHODS: Institutional
      ethics approval and informed consent were obtained. Patients with primary breast 
      cancer (median age, 45 years; age range, 22-70 years) recruited from January 2001
      to September 2008 underwent dynamic contrast-enhanced MR imaging before and after
      two cycles of NAC. Quantitative and semiquantitative kinetic parameters were
      calculated, including the volume transfer constant (K(trans)) and the initial
      area under the gadolinium concentration-time curve over 60 seconds (IAUGC(60)).
      Cut points optimized to the receiver operating characteristic curve were used to 
      dichotomize MR imaging data for Kaplan-Meier survival analysis. MR imaging
      parameters and known prognostic indicators in primary breast cancer were
      correlated with disease-free and overall survival by using the Cox proportional
      hazards model for univariate and multivariate analyses. RESULTS: MR imaging was
      performed before (n = 62) and after (n = 58) two cycles of NAC. The median
      follow-up time was 43.9 months for disease-free survival and 60.3 months for
      overall survival. There were 28 recurrences; 26 patients had distant metastases
      (two had additional local recurrence) and two had local recurrence only. There
      were 20 deaths, all of which were related to breast cancer. At univariate
      analysis, progesterone receptor status, the type of surgery performed, higher
      posttreatment K(trans) (P = .048), and larger posttreatment IAUGC(60) (P = .035) 
      were significant predictors of worse disease-free survival. At multivariate
      analysis, progesterone receptor status (P = .002) and mean transit time (P =
      .025) were significant predictors of disease-free survival. Univariate analysis
      showed that clinical tumor stage (P = .005), progesterone receptor status (P =
      .025), and type of surgery performed (P = .017) were significant predictors of
      overall survival. Higher posttreatment K(trans) (P = .043), larger IAUGC(60) (P =
      .029), and larger tumor size at posttreatment MR imaging were predictive of worse
      overall survival (P = .018). Of these variables, K(trans) remained an independent
      indicator of overall survival (P = .038). CONCLUSION: Higher posttreatment tumor 
      vascularization as depicted with dynamic contrast-enhanced MR imaging may be
      associated with higher recurrence and lower survival rates. Dynamic
      contrast-enhanced MR imaging parameters, in conjunction with traditional
      prognostic factors, have the potential to be prognostic biomarkers for
      disease-free and overall survival in primary breast cancer.
FAU - Li, Sonia P
AU  - Li SP
AD  - Academic Oncology Unit, Mount Vernon Cancer Centre, Rickmansworth Rd, Northwood, 
      Middlesex, HA6 2RN, England. soniali@gmail.com
FAU - Makris, Andreas
AU  - Makris A
FAU - Beresford, Mark J
AU  - Beresford MJ
FAU - Taylor, N Jane
AU  - Taylor NJ
FAU - Ah-See, Mei-Lin W
AU  - Ah-See ML
FAU - Stirling, J James
AU  - Stirling JJ
FAU - d'Arcy, James A
AU  - d'Arcy JA
FAU - Collins, David J
AU  - Collins DJ
FAU - Kozarski, Robert
AU  - Kozarski R
FAU - Padhani, Anwar R
AU  - Padhani AR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110418
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Breast Neoplasms/diagnosis/*drug therapy/*mortality
MH  - Chemotherapy, Adjuvant/mortality
MH  - Contrast Media
MH  - England
MH  - Female
MH  - *Gadolinium DTPA
MH  - Humans
MH  - Magnetic Resonance Imaging/*statistics & numerical data
MH  - Middle Aged
MH  - Neoadjuvant Therapy
MH  - Prevalence
MH  - Prognosis
MH  - Risk Assessment/methods
MH  - Risk Factors
MH  - Survival Analysis
MH  - Survival Rate
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2011/04/20 06:00
MHDA- 2011/09/03 06:00
CRDT- 2011/04/20 06:00
PHST- 2011/04/20 06:00 [entrez]
PHST- 2011/04/20 06:00 [pubmed]
PHST- 2011/09/03 06:00 [medline]
AID - radiol.11102493 [pii]
AID - 10.1148/radiol.11102493 [doi]
PST - ppublish
SO  - Radiology. 2011 Jul;260(1):68-78. doi: 10.1148/radiol.11102493. Epub 2011 Apr 18.


PMID- 21502247
OWN - NLM
STAT- MEDLINE
DCOM- 20110607
LR  - 20131121
IS  - 1098-4275 (Electronic)
IS  - 0031-4005 (Linking)
VI  - 127 Suppl 1
DP  - 2011 May
TI  - A parent's decision on immunization: making the right choice.
PG  - S5-8
LID - 10.1542/peds.2010-1722B [doi]
AB  - A loving parent faces peer pressure to reject routine vaccination of her
      children. She begins researching immunizations to make a well-informed health
      care decision in the best interests of her children. Misleading and frightening
      information is readily accessible. She simply cannot find answers to her
      questions and concerns about vaccines. Her poor choice made in ignorance and fear
      results in her 1-year-old daughter contracting spinal meningitis. Once her
      daughter is in a pediatric intensive care isolation room suffering from this
      deadly disease, the mom gains access to accurate information regarding
      immunizations. All her questions regarding vaccine production, testing, safety,
      and ethics are answered. She wants accurate information readily available to all 
      parents.
FAU - Walther, Suzanne
AU  - Walther S
AD  - sswalther@gmail.com
LA  - eng
PT  - Journal Article
DEP - 20110418
PL  - United States
TA  - Pediatrics
JT  - Pediatrics
JID - 0376422
RN  - 0 (Vaccines)
SB  - IM
MH  - Adult
MH  - Awareness
MH  - Child, Preschool
MH  - *Decision Making
MH  - Drug-Related Side Effects and Adverse Reactions
MH  - Health Education/*organization & administration
MH  - Humans
MH  - Immunization Programs/organization & administration
MH  - Infant
MH  - Male
MH  - Mass Media
MH  - Needs Assessment
MH  - Parent-Child Relations
MH  - Refusal to Participate
MH  - United States
MH  - Vaccination/standards/*trends
MH  - Vaccines/administration & dosage/*adverse effects
EDAT- 2011/04/20 06:00
MHDA- 2011/06/08 06:00
CRDT- 2011/04/20 06:00
PHST- 2011/04/20 06:00 [entrez]
PHST- 2011/04/20 06:00 [pubmed]
PHST- 2011/06/08 06:00 [medline]
AID - peds.2010-1722B [pii]
AID - 10.1542/peds.2010-1722B [doi]
PST - ppublish
SO  - Pediatrics. 2011 May;127 Suppl 1:S5-8. doi: 10.1542/peds.2010-1722B. Epub 2011
      Apr 18.


PMID- 21502232
OWN - NLM
STAT- MEDLINE
DCOM- 20110711
LR  - 20220409
IS  - 1098-4275 (Electronic)
IS  - 0031-4005 (Linking)
VI  - 127
IP  - 5
DP  - 2011 May
TI  - Ethics of resuscitation at different stages of life: a survey of perinatal
      physicians.
PG  - e1221-9
LID - 10.1542/peds.2010-1031 [doi]
AB  - OBJECTIVE: We surveyed US neonatologists and high-risk obstetricians about
      preferences for resuscitation in ethically difficult situations to determine
      whether (1) their responses adhered to traditional ethical principles of best
      interests and patient autonomy and (2) physician specialty seemed to influence
      the response. METHODS: In an electronic survey, we presented 8 vignettes with
      varying prognoses for survival and long-term outcome. Respondents were provided
      outcome data for mortality and morbidity in each vignette. We asked whether
      resuscitation was in the patient's best interest and whether the physician would 
      accede to requests for nonresuscitation. RESULTS: We analyzed surveys for 587
      neonatologists and 108 high-risk obstetricians (15% overall response rate, 75% of
      web site visitors). There were no statistically significant differences in
      responses between the 2 physician subspecialty groups. As expected, in most cases
      there were inverse relationships between valuation of best interest and deferred 
      resuscitation at the family's request. For example, for the oldest patient (an
      80-year-old), 9.9% found resuscitation to be in the patient's best interest and
      94.3% would allow nonresuscitation; for a 2-month-old, 93.9% found resuscitation 
      to be in the patient's best interest and 24.5% would allow nonresuscitation.
      However, this pattern was not observed in the 2 newborn cases, in which
      resuscitation and nonresuscitation were both acceptable. In the triage scenario, 
      the 7-year-old with cerebral palsy and acute trauma was consistently resuscitated
      first despite others having equivalent or better short- and long-term prognoses. 
      CONCLUSIONS: On the basis of our results, physicians' decisions to resuscitate
      seem to be context-specific, rather than based on prognosis or consistent
      application of best-interest or autonomy principles. Despite their different
      professional perspectives, neonatologists and high-risk obstetricians seemed to
      converge on these judgments.
FAU - Laventhal, Naomi
AU  - Laventhal N
AD  - University of Michigan Health System, F5790 C.S. Mott Children's Hospital, 1500 E
      Medical Center Dr, SPC 5254, Ann Arbor, MI 48109-5254, USA.
      naomilav@med.umich.edu
FAU - Spelke, M Bridget
AU  - Spelke MB
FAU - Andrews, Bree
AU  - Andrews B
FAU - Larkin, L Knoll
AU  - Larkin LK
FAU - Meadow, William
AU  - Meadow W
FAU - Janvier, Annie
AU  - Janvier A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110418
PL  - United States
TA  - Pediatrics
JT  - Pediatrics
JID - 0376422
SB  - IM
CIN - Evid Based Nurs. 2012 Jan;15(1):9. PMID: 22108562
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged, 80 and over
MH  - Attitude of Health Personnel
MH  - Child
MH  - Child, Preschool
MH  - Decision Making/ethics
MH  - Female
MH  - Health Care Surveys
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Obstetrics/*ethics/methods
MH  - Perinatology/*ethics/methods
MH  - Physician-Patient Relations
MH  - Practice Patterns, Physicians'/ethics/trends
MH  - *Professional Autonomy
MH  - Resuscitation/*ethics/trends
MH  - Risk Factors
MH  - Surveys and Questionnaires
MH  - Total Quality Management
MH  - Young Adult
EDAT- 2011/04/20 06:00
MHDA- 2011/07/12 06:00
CRDT- 2011/04/20 06:00
PHST- 2011/04/20 06:00 [entrez]
PHST- 2011/04/20 06:00 [pubmed]
PHST- 2011/07/12 06:00 [medline]
AID - peds.2010-1031 [pii]
AID - 10.1542/peds.2010-1031 [doi]
PST - ppublish
SO  - Pediatrics. 2011 May;127(5):e1221-9. doi: 10.1542/peds.2010-1031. Epub 2011 Apr
      18.


PMID- 21501267
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20131121
IS  - 1365-2354 (Electronic)
IS  - 0961-5423 (Linking)
VI  - 20
IP  - 5
DP  - 2011 Sep
TI  - Perceptions of the ethical conduct of cancer trials by oncology nurses.
PG  - 585-92
LID - 10.1111/j.1365-2354.2011.01251.x [doi]
AB  - Informed consent and subject protection are internationally mandated requirements
      for the ethical conduct of research; however, the monitoring of the day-to-day
      conduct of research may be insufficient for ensuring consistent compliance with
      required ethical ideals. Oncology nurses were surveyed about their perceptions of
      ethical issues relevant to cancer trials research. Utilising an
      investigator-developed instrument, multi-item scales assessed six ethical
      domains. Of 192 respondents, 95% or more held definite views in 12 of 15 items
      about patient understanding of cancer trials, informed consent and the welfare of
      participants. Approximately 95% perceived that patients consented freely and knew
      how to withdraw from a trial, and 81% perceived better monitoring of trial than
      non-trial patients. However, more than 80% of respondents perceived that at times
      patients had unrealistic expectations of participation, and more than 50%
      perceived that participants sometimes did not understand the nature and risk of
      cancer trials. Although the conative attributes of patients place limits on the
      goals of bioethics, the results of this study show first that oncology nurses
      have opinions about ethical constructs directly linked to the daily conduct of
      cancer clinical trials, and second that this link warrants further investigation 
      in order to benchmark trial conduct against the ideals of ethical research.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Beadle, G
AU  - Beadle G
AD  - Translational Research Laboratory, Queensland Institute of Medical Research,
      Brisbane, Qld, Australia. geoffbe@qimr.edu.au
FAU - Mengersen, K
AU  - Mengersen K
FAU - Moynihan, S
AU  - Moynihan S
FAU - Yates, P
AU  - Yates P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110419
PL  - England
TA  - Eur J Cancer Care (Engl)
JT  - European journal of cancer care
JID - 9301979
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Clinical Trials as Topic/*ethics/standards
MH  - *Ethics, Medical
MH  - Female
MH  - Humans
MH  - Informed Consent/ethics
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/*therapy
MH  - Nurses/*psychology
MH  - Oncology Nursing
MH  - Young Adult
EDAT- 2011/04/20 06:00
MHDA- 2011/10/25 06:00
CRDT- 2011/04/20 06:00
PHST- 2011/04/20 06:00 [entrez]
PHST- 2011/04/20 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
AID - 10.1111/j.1365-2354.2011.01251.x [doi]
PST - ppublish
SO  - Eur J Cancer Care (Engl). 2011 Sep;20(5):585-92. doi:
      10.1111/j.1365-2354.2011.01251.x. Epub 2011 Apr 19.


PMID- 21501049
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20110818
IS  - 1360-046X (Electronic)
IS  - 0268-8697 (Linking)
VI  - 25
IP  - 5
DP  - 2011 Oct
TI  - Radionecrosis following Gamma Knife treatment for mesial temporal lobe epilepsy.
PG  - 649-51
LID - 10.3109/02688697.2011.552651 [doi]
AB  - A 24-year-old male patient was treated with Gamma Knife surgery (GKS) for medial 
      temporal lobe epilepsy. The treatment parameters were in accordance with
      established practice. Epilepsy stopped after 2 years and medication was
      discontinued. Four years later, he developed a profound radionecrosis leading to 
      blindness. As had refused surgical intervention his blindness has become
      permanent. As this is the second such case to be reported, it is considered a
      cause for concern, since microsurgery remains a safe alternative treatment. It is
      suggested that GKS for mesial temporal lobe epilepsy should be restricted to
      University centres of excellence as part of research projects under the control
      of ethics committees. It should not at present be considered to be a safe
      treatment for general use.
FAU - Ganz, Jeremy C
AU  - Ganz JC
AD  - Shantou University Medical College, Shantou, China. jcganz@gmail.com
FAU - Reda, Wael Abdelhalim
AU  - Reda WA
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20110418
PL  - England
TA  - Br J Neurosurg
JT  - British journal of neurosurgery
JID - 8800054
SB  - IM
MH  - Blindness/*etiology
MH  - Epilepsy, Temporal Lobe/*surgery
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Necrosis
MH  - Radiation Dosage
MH  - Radiation Injuries/*pathology
MH  - Radiosurgery/*adverse effects/instrumentation
MH  - Treatment Refusal
MH  - Visual Pathways/*pathology
MH  - Young Adult
EDAT- 2011/04/20 06:00
MHDA- 2011/11/09 06:00
CRDT- 2011/04/20 06:00
PHST- 2011/04/20 06:00 [entrez]
PHST- 2011/04/20 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - 10.3109/02688697.2011.552651 [doi]
PST - ppublish
SO  - Br J Neurosurg. 2011 Oct;25(5):649-51. doi: 10.3109/02688697.2011.552651. Epub
      2011 Apr 18.


PMID- 21500692
OWN - NLM
STAT- MEDLINE
DCOM- 20110525
LR  - 20161125
IS  - 0029-6570 (Print)
IS  - 0029-6570 (Linking)
VI  - 25
IP  - 29
DP  - 2011 Mar 23-29
TI  - Nurse prescribing ethics and medical marketing.
PG  - 62-6
AB  - This article suggests that nurse prescribers require an awareness of key concepts
      in ethics, such as deontology and utilitarianism to reflect on current debates
      and contribute to them. The principles of biomedical ethics have also been
      influential in the development of professional codes of conduct. Attention is
      drawn to the importance of the Association of the British Pharmaceutical
      Industry's code of practice for the pharmaceutical industry in regulating
      marketing aimed at prescribers.
FAU - Adams, J
AU  - Adams J
AD  - Anglia Ruskin University, Peterborough. frosses02@btinternet.com
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Stand
JT  - Nursing standard (Royal College of Nursing (Great Britain) : 1987)
JID - 9012906
MH  - *Drug Prescriptions
MH  - *Ethics, Nursing
MH  - Humans
MH  - *Nurses
MH  - United Kingdom
EDAT- 2011/04/20 06:00
MHDA- 2011/05/26 06:00
CRDT- 2011/04/20 06:00
PHST- 2011/04/20 06:00 [entrez]
PHST- 2011/04/20 06:00 [pubmed]
PHST- 2011/05/26 06:00 [medline]
AID - 10.7748/ns2011.03.25.29.62.c8405 [doi]
PST - ppublish
SO  - Nurs Stand. 2011 Mar 23-29;25(29):62-6. doi: 10.7748/ns2011.03.25.29.62.c8405.


PMID- 21500008
OWN - NLM
STAT- MEDLINE
DCOM- 20110711
LR  - 20181201
IS  - 1364-6915 (Electronic)
IS  - 1360-7863 (Linking)
VI  - 15
IP  - 4
DP  - 2011 May
TI  - Ethics of using assistive technology in the care for community-dwelling elderly
      people: an overview of the literature.
PG  - 419-27
LID - 10.1080/13607863.2010.543662 [doi]
AB  - OBJECTIVES: This article provides an overview of the international literature on 
      the most important ethical considerations in the field of assistive technology
      (AT) in the care for community-dwelling elderly people, focused on dementia.
      METHOD: A systematic literature review was performed. RESULTS: A total of 46
      papers met the inclusion criteria. Three main themes were found. The first theme,
      personal living environment, involves the subthemes privacy, autonomy and
      obtrusiveness. The second theme, the outside world, involves the subthemes stigma
      and human contact. The third theme, the design of AT devices, involves the
      subthemes individual approach, affordability and safety. The often referred to
      umbrella term of 'obtrusiveness' is frequently used by many authors in the
      discussion, while a clear description of the concept is mostly absent.
      CONCLUSION: When it comes to AT use in the care for elderly people living at
      home, ethical debate appears not to be a priority. The little discussion there
      relies heavily on thick concepts such as autonomy and obtrusiveness which seem to
      complicate the debate rather than clarify it, because they contain many
      underlying ambiguous concepts and assumptions. Most encountered ethical
      objections originate from the view that people are, or should be, independent and
      self-determinant. It is questionable whether the view is correct and helpful in
      the debate on AT use in the care for (frail) elderly people. Other ethical
      approaches that view people as social and reciprocal might be more applicable and
      shed a different light on the ethical aspects of AT use.
FAU - Zwijsen, Sandra A
AU  - Zwijsen SA
AD  - Department of Nursing Home Medicine, EMGO+ Institute for Health and Care
      Research, VU University Medical Center, Amsterdam, The Netherlands.
      s.zwijsen@vumc.nl
FAU - Niemeijer, Alistair R
AU  - Niemeijer AR
FAU - Hertogh, Cees M P M
AU  - Hertogh CM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
PL  - England
TA  - Aging Ment Health
JT  - Aging & mental health
JID - 9705773
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Community Health Services
MH  - Dementia/*rehabilitation
MH  - Female
MH  - Frail Elderly
MH  - *Home Care Services
MH  - Home Nursing/*ethics/methods
MH  - Humans
MH  - Male
MH  - Personal Autonomy
MH  - Privacy
MH  - Self-Help Devices/*ethics
MH  - Social Environment
MH  - Telemedicine/*ethics/instrumentation
EDAT- 2011/04/19 06:00
MHDA- 2011/07/12 06:00
CRDT- 2011/04/19 06:00
PHST- 2011/04/19 06:00 [entrez]
PHST- 2011/04/19 06:00 [pubmed]
PHST- 2011/07/12 06:00 [medline]
AID - 936414677 [pii]
AID - 10.1080/13607863.2010.543662 [doi]
PST - ppublish
SO  - Aging Ment Health. 2011 May;15(4):419-27. doi: 10.1080/13607863.2010.543662.


PMID- 21498335
OWN - NLM
STAT- MEDLINE
DCOM- 20110711
LR  - 20110418
IS  - 1600-0455 (Electronic)
IS  - 0284-1851 (Linking)
VI  - 52
IP  - 1
DP  - 2011 Feb 1
TI  - Staging of hip avascular necrosis: is there a need for DWI?
PG  - 111-4
LID - 10.1258/ar.2010.100231 [doi]
AB  - BACKGROUND: No comprehensive study has been performed to stage avascular necrosis
      of the hip using diffusion-weighted imaging (DWI). PURPOSE: To determine apparent
      diffusion co-efficient (ADC) alterations in hip avascular necrosis (AVN) and to
      determine variations of ADC values according to stages of disease. MATERIAL AND
      METHODS: The study is approved by our institutional review board and local
      ethical committee. Written informed consent was present for each subject.
      Thirty-five femoral heads of 21 cases affected by AVN were included in the study.
      Control group consisted of both femoral heads of 10 healthy volunteers. The hips 
      affected by AVN were staged according to Ficat and Arlet classification system
      from I to IV. All cases underwent to routine hip magnetic resonance imaging (MRI)
      and DWI performed with a single-shot fast spin echo sequence at a b value of 600 
      s/mm(2). The ADC values were calculated automatically by placing ROIs on AVN
      lesions in affected patients and both femoral heads of control group. The median 
      ADC value obtained from femoral heads of control group and that from AVN lesions 
      were compared by Mann-Whitney U test. The median ADC values of AVN lesions at
      different stages were compared by Kruskal-Wallis test. RESULTS: The median ADC
      value of normal bone measured in control group was 185.5 +/- 133.2 x 10(-6)
      mm(2)/s. The median ADC value measured in hip avascular necrosis lesions was
      988.0 +/- 332.7 x 10(-6) mm(2)/s. ADC values in hip AVN lesions were
      statistically significantly higher than normal bone marrow (P<0.01). The median
      ADC values of hips with avascular necrosis at stage I, II, III, IV were 817.5 +/-
      172.1 x 10(-6) mm(2)/s, 902.0 +/- 181.0 x 10(-6) mm(2)/s, 1200.0 +/- 363.2 x
      10(-6) mm(2)/s and 1024.0 +/- 324.0 x 10(-6) mm(2)/s, respectively. There was no 
      statistically significant difference among AVN lesions at stages I, II, III and
      IV (P>0.05). CONCLUSION: Although DWI is a promising imaging tool that provides
      valuable diagnostic information in hip AVN, it fails to distinguish between
      different stages, and therefore is of limited value.
FAU - Oner, A Yusuf
AU  - Oner AY
AD  - Gazi University School of Medicine Department of Radiology, Ankara, Turkey.
      yusuf@tr.net
FAU - Aggunlu, Levent
AU  - Aggunlu L
FAU - Akpek, Sergin
AU  - Akpek S
FAU - Celik, Azim
AU  - Celik A
FAU - Le Roux, Patrick
AU  - Le Roux P
FAU - Tali, Turgut
AU  - Tali T
FAU - Gultekin, Serap
AU  - Gultekin S
LA  - eng
PT  - Journal Article
PL  - England
TA  - Acta Radiol
JT  - Acta radiologica (Stockholm, Sweden : 1987)
JID - 8706123
SB  - IM
MH  - Adult
MH  - Aged
MH  - Diffusion Magnetic Resonance Imaging/*methods
MH  - Female
MH  - Femur Head Necrosis/*pathology
MH  - Hip Joint/*pathology
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Middle Aged
MH  - Observer Variation
MH  - Severity of Illness Index
MH  - Young Adult
EDAT- 2011/04/19 06:00
MHDA- 2011/07/12 06:00
CRDT- 2011/04/19 06:00
PHST- 2011/04/19 06:00 [entrez]
PHST- 2011/04/19 06:00 [pubmed]
PHST- 2011/07/12 06:00 [medline]
AID - 52/1/111 [pii]
AID - 10.1258/ar.2010.100231 [doi]
PST - ppublish
SO  - Acta Radiol. 2011 Feb 1;52(1):111-4. doi: 10.1258/ar.2010.100231.


PMID- 21498293
OWN - NLM
STAT- MEDLINE
DCOM- 20110708
LR  - 20161125
IS  - 1600-0455 (Electronic)
IS  - 0284-1851 (Linking)
VI  - 52
IP  - 4
DP  - 2011 May 1
TI  - Clinical and radiological features of pandemic H1N1 2009 influenza virus
      infection manifesting as acute febrile respiratory illness at their initial
      presentations: comparison with contemporaneous non-H1N1 patients.
PG  - 410-6
LID - 10.1258/ar.2011.100411 [doi]
AB  - BACKGROUND: Since the first outbreak caused by the pandemic H1N1 2009 influenza
      in Mexico, the virus has spread widely across the world with meaningful morbidity
      and mortality. However, there are few data on the comparative investigations to
      assess the clinical and radiological features between the H1N1 patient and
      non-H1N1 patients. PURPOSE: To assess the clinical and radiological features of
      patients infected by the pandemic H1N1 2009 flu virus at their initial
      presentation and to compare them with contemporaneous non-H1N1 patients with
      acute febrile respiratory illness. MATERIAL AND METHODS: This retrospective study
      was approved by the ethics committee of the Armed Forces Medical Command, South
      Korea. From August to September 2009, 337 consecutive patients presented with an 
      acute febrile respiratory illness in a tertiary military hospital.
      Reverse-transcriptase polymerase-chain-reaction tests were performed in 62 of
      these patients under the impression of H1N1 infection. Clinical and radiological 
      features at their initial presentation were described for the H1N1 group (n = 35)
      and non-H1N1 group (n = 27) and compared between the two groups. RESULTS:
      Increased C-reactive protein level (97%) without leukocytosis (9%) or increased
      erythrocyte sedimentation rate (0%) was common in the H1N1 group at their initial
      presentation. On chest radiographs, 12 of 35 (34%) H1N1 patients had abnormal
      findings; nodules in 10 patients (83%) and consolidations in two (17%). Of the 28
      H1N1 patients who underwent thin-section CT 16 patients (57%) showed abnormal
      findings; ground-glass opacities (GGOs) in 15 (94%), and nodules in 13 (81%).
      However, there were no significant differences between the H1N1 group and
      non-H1N1 group in terms of symptoms, laboratory results, or radiological findings
      (P > 0.05). CONCLUSION: Patients with H1N1 infection show consistent clinical and
      radiological features at their initial presentation, however, clinical and
      radiological features of the H1N1 group are not significantly different from
      those of the non-H1N1 group.
FAU - Yun, Tae Jin
AU  - Yun TJ
AD  - Department of Radiology, Armed Force Byukjae Hospital, Gyeonggi-do, Korea.
FAU - Park, Chang Min
AU  - Park CM
FAU - Kwon, Gu Jin
AU  - Kwon GJ
FAU - Woo, Sung Koo
AU  - Woo SK
FAU - Park, Seung Hoon
AU  - Park SH
FAU - Choi, Seung Hong
AU  - Choi SH
FAU - Lee, Hyun Ju
AU  - Lee HJ
FAU - Goo, Jin Mo
AU  - Goo JM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110309
PL  - England
TA  - Acta Radiol
JT  - Acta radiologica (Stockholm, Sweden : 1987)
JID - 8706123
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Acute Disease
MH  - Blood Sedimentation
MH  - C-Reactive Protein/analysis
MH  - Fever
MH  - Humans
MH  - *Influenza A Virus, H1N1 Subtype
MH  - Influenza, Human/*diagnostic imaging/epidemiology
MH  - Male
MH  - *Pandemics
MH  - Radiography, Thoracic
MH  - Republic of Korea/epidemiology
MH  - Respiratory Tract Diseases/diagnostic imaging
MH  - Retrospective Studies
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Tomography, X-Ray Computed
MH  - Young Adult
EDAT- 2011/04/19 06:00
MHDA- 2011/07/09 06:00
CRDT- 2011/04/19 06:00
PHST- 2011/04/19 06:00 [entrez]
PHST- 2011/04/19 06:00 [pubmed]
PHST- 2011/07/09 06:00 [medline]
AID - ar.2011.100411 [pii]
AID - 10.1258/ar.2011.100411 [doi]
PST - ppublish
SO  - Acta Radiol. 2011 May 1;52(4):410-6. doi: 10.1258/ar.2011.100411. Epub 2011 Mar
      9.


PMID- 21498175
OWN - NLM
STAT- MEDLINE
DCOM- 20110620
LR  - 20220321
IS  - 2042-7670 (Electronic)
IS  - 0042-4900 (Linking)
VI  - 168
IP  - 10
DP  - 2011 Mar 12
TI  - Veterinary opinions on refusing euthanasia: justifications and philosophical
      frameworks.
PG  - 263
LID - 10.1136/vr.c6352 [doi]
AB  - To obtain information on euthanasia decisions from practising veterinary
      surgeons, respondents were asked to estimate how often during their time in
      practice they had refused to euthanase a dog and how often they had wanted to
      refuse to euthanase a dog but not done so because of other pressures. For each,
      respondents were then asked to state their most common reasons for refusing/not
      refusing in free text. The responses of clinicians were considered in the light
      of established ethical concepts to produce an evidence-based ethical framework
      for decision making. In total, 58 practitioners responded. Common reasons given
      for decisions on whether to refuse euthanasia referred to the patient's
      interests, such as the possibility of treatment or rehoming, and the fear of
      other unacceptable outcomes for the dog. Other reasons were based on concern for 
      owners' interests. Some respondents reported being pressured into euthanasia by
      clients and other veterinary surgeons. This gives insight into the ethical
      principles that explicitly underlie veterinary surgeons' euthanasia decisions and
      the resultant framework may be useful for discussing and teaching euthanasia.
FAU - Yeates, J W
AU  - Yeates JW
AD  - Department of Clinical Veterinary Science, University of Bristol, Myrtle Cottage,
      Stock Lane, Langford, Bristol BS40 5EW. james.yeates@bristol.ac.uk
FAU - Main, D C J
AU  - Main DC
LA  - eng
PT  - Journal Article
DEP - 20110228
PL  - England
TA  - Vet Rec
JT  - The Veterinary record
JID - 0031164
SB  - IM
MH  - Animal Welfare
MH  - Animals
MH  - Animals, Domestic
MH  - Cats
MH  - Decision Making
MH  - Dogs
MH  - *Ethics, Professional
MH  - Euthanasia, Animal/*ethics
MH  - Housing, Animal
MH  - Human-Animal Bond
MH  - Humans
MH  - Ownership
MH  - *Practice Patterns, Physicians'
MH  - Public Opinion
MH  - Veterinarians/*ethics/*psychology
EDAT- 2011/04/19 06:00
MHDA- 2011/06/21 06:00
CRDT- 2011/04/19 06:00
PHST- 2011/04/19 06:00 [entrez]
PHST- 2011/04/19 06:00 [pubmed]
PHST- 2011/06/21 06:00 [medline]
AID - vr.c6352 [pii]
AID - 10.1136/vr.c6352 [doi]
PST - ppublish
SO  - Vet Rec. 2011 Mar 12;168(10):263. doi: 10.1136/vr.c6352. Epub 2011 Feb 28.


PMID- 21498122
OWN - NLM
STAT- MEDLINE
DCOM- 20110928
LR  - 20110606
IS  - 1472-6491 (Electronic)
IS  - 1472-6483 (Linking)
VI  - 22
IP  - 7
DP  - 2011 Jun
TI  - Robert G Edwards and the Roman Catholic Church.
PG  - 665-72
LID - 10.1016/j.rbmo.2011.03.004 [doi]
AB  - The Roman Catholic Church reacted negatively to the announcement that the Nobel
      Prize for Medicine had been awarded to Robert G Edwards. Thirty-three years ago, 
      Cardinal Albino Luciani, on the eve of his election to become Pope, stated that, 
      whereas progress is certainly a beautiful thing, mankind has not always benefited
      from progress. Catholic criticism has raised seven points: (i) God wants human
      life to begin through the 'conjugal act' and not artificially; (ii) artificial
      interventions at the beginning of human life are dangerous and ethically
      unacceptable; (iii) limits can be imposed even upon an individual's freedom to
      achieve a legitimate goal, such as having a child within marriage; (iv) the
      massive loss of preimplantation embryos characterizing IVF must be considered as 
      a tragic loss of 'nascent' human persons; (v) Edwards bears a moral
      responsibility for all subsequent developments in assisted reproduction
      technology and for all 'abuses' made possible by IVF; (vi) there can be
      deleterious consequences for offspring of assisted reproduction technology; and
      (vii) Edwards' discovery did not eliminate the causes of infertility. This
      article elaborates from the Roman Catholic perspective on each of these points,
      some of which are found to be more substantial than others.
CI  - Copyright (c) 2011 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All
      rights reserved.
FAU - Benagiano, Giuseppe
AU  - Benagiano G
AD  - Department of Gynaecology, Obstetrics and Urology, Sapienza, University of Rome, 
      Italy. gbenagiano@libero.it
FAU - Carrara, Sabina
AU  - Carrara S
FAU - Filippi, Valentina
AU  - Filippi V
LA  - eng
PT  - Journal Article
DEP - 20110311
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
SB  - IM
CIN - Reprod Biomed Online. 2011 Jun;22(7):663-4. PMID: 21493150
CIN - Reprod Biomed Online. 2011 Jun;22(7):661-2. PMID: 21493153
CIN - Reprod Biomed Online. 2011 Jun;22(7):658-60. PMID: 21493155
MH  - Beginning of Human Life
MH  - *Catholicism
MH  - Coitus
MH  - Embryo, Mammalian
MH  - Fertilization in Vitro/adverse effects/*ethics
MH  - Humans
MH  - Infertility/therapy
MH  - Nobel Prize
MH  - *Religion and Medicine
MH  - Reproductive Medicine
MH  - Social Responsibility
EDAT- 2011/04/19 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/04/19 06:00
PHST- 2010/11/23 00:00 [received]
PHST- 2011/01/12 00:00 [revised]
PHST- 2011/03/03 00:00 [accepted]
PHST- 2011/04/19 06:00 [entrez]
PHST- 2011/04/19 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - S1472-6483(11)00157-X [pii]
AID - 10.1016/j.rbmo.2011.03.004 [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2011 Jun;22(7):665-72. doi: 10.1016/j.rbmo.2011.03.004.
      Epub 2011 Mar 11.


PMID- 21496358
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1742-9994 (Electronic)
IS  - 1742-9994 (Linking)
VI  - 8
IP  - 1
DP  - 2011 Apr 18
TI  - Mitigating amphibian disease: strategies to maintain wild populations and control
      chytridiomycosis.
PG  - 8
LID - 10.1186/1742-9994-8-8 [doi]
AB  - BACKGROUND: Rescuing amphibian diversity is an achievable conservation challenge.
      Disease mitigation is one essential component of population management. Here we
      assess existing disease mitigation strategies, some in early experimental stages,
      which focus on the globally emerging chytrid fungus Batrachochytrium
      dendrobatidis. We discuss the precedent for each strategy in systems ranging from
      agriculture to human medicine, and the outlook for each strategy in terms of
      research needs and long-term potential. RESULTS: We find that the effects of
      exposure to Batrachochytrium dendrobatidis occur on a spectrum from transient
      commensal to lethal pathogen. Management priorities are divided between (1)
      halting pathogen spread and developing survival assurance colonies, and (2)
      prophylactic or remedial disease treatment. Epidemiological models of
      chytridiomycosis suggest that mitigation strategies can control disease without
      eliminating the pathogen. Ecological ethics guide wildlife disease research, but 
      several ethical questions remain for managing disease in the field. CONCLUSIONS: 
      Because sustainable conservation of amphibians in nature is dependent on
      long-term population persistence and co-evolution with potentially lethal
      pathogens, we suggest that disease mitigation not focus exclusively on the
      elimination or containment of the pathogen, or on the captive breeding of
      amphibian hosts. Rather, successful disease mitigation must be context specific
      with epidemiologically informed strategies to manage already infected populations
      by decreasing pathogenicity and host susceptibility. We propose population level 
      treatments based on three steps: first, identify mechanisms of disease
      suppression; second, parameterize epizootiological models of disease and
      population dynamics for testing under semi-natural conditions; and third, begin a
      process of adaptive management in field trials with natural populations.
FAU - Woodhams, Douglas C
AU  - Woodhams DC
AD  - Institute of Evolutionary Biology and Environmental Studies, University of
      Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
      dwoodhams@gmail.com.
FAU - Bosch, Jaime
AU  - Bosch J
FAU - Briggs, Cheryl J
AU  - Briggs CJ
FAU - Cashins, Scott
AU  - Cashins S
FAU - Davis, Leyla R
AU  - Davis LR
FAU - Lauer, Antje
AU  - Lauer A
FAU - Muths, Erin
AU  - Muths E
FAU - Puschendorf, Robert
AU  - Puschendorf R
FAU - Schmidt, Benedikt R
AU  - Schmidt BR
FAU - Sheafor, Brandon
AU  - Sheafor B
FAU - Voyles, Jamie
AU  - Voyles J
LA  - eng
PT  - Journal Article
DEP - 20110418
PL  - England
TA  - Front Zool
JT  - Frontiers in zoology
JID - 101231669
PMC - PMC3098159
EDAT- 2011/04/19 06:00
MHDA- 2011/04/19 06:01
CRDT- 2011/04/19 06:00
PHST- 2010/09/24 00:00 [received]
PHST- 2011/04/18 00:00 [accepted]
PHST- 2011/04/19 06:00 [entrez]
PHST- 2011/04/19 06:00 [pubmed]
PHST- 2011/04/19 06:01 [medline]
AID - 1742-9994-8-8 [pii]
AID - 10.1186/1742-9994-8-8 [doi]
PST - epublish
SO  - Front Zool. 2011 Apr 18;8(1):8. doi: 10.1186/1742-9994-8-8.


PMID- 21496244
OWN - NLM
STAT- MEDLINE
DCOM- 20110725
LR  - 20211020
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 12
DP  - 2011 Apr 15
TI  - Ethical issues in autologous stem cell transplantation (ASCT) in advanced breast 
      cancer: a systematic literature review.
PG  - 6
LID - 10.1186/1472-6939-12-6 [doi]
AB  - BACKGROUND: An effectiveness assessment on ASCT in locally advanced and
      metastatic breast cancer identified serious ethical issues associated with this
      intervention. Our objective was to systematically review these aspects by means
      of a literature analysis. METHODS: We chose the reflexive Socratic approach as
      the review method using Hofmann's question list, conducted a comprehensive
      literature search in biomedical, psychological and ethics bibliographic databases
      and screened the resulting hits in a 2-step selection process. Relevant arguments
      were assembled from the included articles, and were assessed and assigned to the 
      question list. Hofmann's questions were addressed by synthesizing these
      arguments. RESULTS: Of the identified 879 documents 102 included arguments
      related to one or more questions from Hofmann's question list. The most important
      ethical issues were the implementation of ASCT in clinical practice on the basis 
      of phase-II trials in the 1990s and the publication of falsified data in the
      first randomized controlled trials (Bezwoda fraud), which caused significant
      negative effects on recruiting patients for further clinical trials and the
      doctor-patient relationship. Recent meta-analyses report a marginal effect in
      prolonging disease-free survival, accompanied by severe harms, including death.
      ASCT in breast cancer remains a stigmatized technology. Reported
      health-related-quality-of-life data are often at high risk of bias in favor of
      the survivors. Furthermore little attention has been paid to those patients who
      were dying. CONCLUSIONS: The questions were addressed in different degrees of
      completeness. All arguments were assignable to the questions. The central ethical
      dimensions of ASCT could be discussed by reviewing the published literature.
FAU - Droste, Sigrid
AU  - Droste S
AD  - Institute for Quality and Efficiency in Health Care (IQWiG), Cologne, Germany.
      Sigrid.Droste@iqwig.de
FAU - Herrmann-Frank, Annegret
AU  - Herrmann-Frank A
FAU - Scheibler, Fueloep
AU  - Scheibler F
FAU - Krones, Tanja
AU  - Krones T
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20110415
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Breast Neoplasms/pathology/*surgery
MH  - Disease-Free Survival
MH  - Female
MH  - Humans
MH  - Informed Consent/ethics
MH  - Meta-Analysis as Topic
MH  - Neoplasm Staging
MH  - Personal Autonomy
MH  - Personhood
MH  - Publishing/*ethics
MH  - Quality of Life
MH  - Randomized Controlled Trials as Topic/ethics
MH  - Research Design
MH  - *Scientific Misconduct/ethics
MH  - *Social Values
MH  - Stem Cell Transplantation/*ethics/*mortality
MH  - Transplantation, Autologous/ethics
PMC - PMC3103481
EDAT- 2011/04/19 06:00
MHDA- 2011/07/26 06:00
CRDT- 2011/04/19 06:00
PHST- 2010/10/29 00:00 [received]
PHST- 2011/04/15 00:00 [accepted]
PHST- 2011/04/19 06:00 [entrez]
PHST- 2011/04/19 06:00 [pubmed]
PHST- 2011/07/26 06:00 [medline]
AID - 1472-6939-12-6 [pii]
AID - 10.1186/1472-6939-12-6 [doi]
PST - epublish
SO  - BMC Med Ethics. 2011 Apr 15;12:6. doi: 10.1186/1472-6939-12-6.


PMID- 21495964
OWN - NLM
STAT- MEDLINE
DCOM- 20120112
LR  - 20191027
IS  - 1996-3181 (Electronic)
IS  - 1871-5273 (Linking)
VI  - 10
IP  - 4
DP  - 2011 Jun
TI  - Emerging restorative treatments for Parkinson's disease: manipulation and
      inducement of dopaminergic neurons from adult stem cells.
PG  - 509-16
AB  - Parkinson's disease (PD) is a common neurodegenerative disease, characterized by 
      a selective loss of midbrain Dopaminergic (DA) neurons. To address this problem, 
      various types of stem cells that have potential to differentiate into DA neurons 
      are being investigated as cellular therapies for PD, including cells derived from
      embryonic or adult donor tissue, and embryonic stem cells. These cell sources,
      however, have raised certain questions with regard to ethical and rejection
      issues. Recent progress in adult stems has further proved that the cells derived 
      from adult tissue could be expanded and differentiated into DA precursor cells in
      vitro, and cell therapy with adult stem cells could produce a clear improvement
      for PD models. Using adult stem cells for clinic application may not only
      overcome the ethical problem inherent in using human fetal tissue or embryonic
      stem cells, but also open the possibility for autologous transplantation. The
      patient-specific adult stem cell is therefore a potential and prospective
      candidate for PD treatment.
FAU - Zhao, Junpeng
AU  - Zhao J
AD  - Beijing Institute for Neuroscience, Beijing Center for Neural Regeneration and
      Repair, Key Laboratory for Neurodegenerative Diseases of the Ministry of
      Education, Capital Medical University, No.10 Xi tou tiao, You an men, Beijing
      100069, P.R. China. xuqy@ccmu.edu.cn.
FAU - Xu, Qunyuan
AU  - Xu Q
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - CNS Neurol Disord Drug Targets
JT  - CNS & neurological disorders drug targets
JID - 101269155
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Adult
MH  - Adult Stem Cells/*transplantation
MH  - Cell Differentiation/physiology
MH  - Dopamine/physiology
MH  - Dopaminergic Neurons/*physiology
MH  - Embryonic Stem Cells/transplantation
MH  - Humans
MH  - Parkinson Disease/*therapy
MH  - Stem Cell Transplantation/*methods
MH  - Transplantation, Autologous/*methods/physiology
EDAT- 2011/04/19 06:00
MHDA- 2012/01/13 06:00
CRDT- 2011/04/19 06:00
PHST- 2010/09/01 00:00 [received]
PHST- 2010/12/24 00:00 [accepted]
PHST- 2011/04/19 06:00 [entrez]
PHST- 2011/04/19 06:00 [pubmed]
PHST- 2012/01/13 06:00 [medline]
AID - BSP/CDTCNSND/E-Pub/00120 [pii]
AID - 10.2174/187152711795563921 [doi]
PST - ppublish
SO  - CNS Neurol Disord Drug Targets. 2011 Jun;10(4):509-16. doi:
      10.2174/187152711795563921.


PMID- 21495603
OWN - NLM
STAT- MEDLINE
DCOM- 20110701
LR  - 20191210
IS  - 1055-3134 (Print)
IS  - 1055-3134 (Linking)
VI  - 74
IP  - 1
DP  - 2011 Spring
TI  - Ethics empowerment: deal with moral distress.
PG  - 1, 4
FAU - Payne, Kate
AU  - Payne K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Tenn Nurse
JT  - Tennessee nurse
JID - 9102869
MH  - Burnout, Professional/*prevention & control
MH  - *Conflict, Psychological
MH  - Humans
MH  - Nursing Care/*ethics
MH  - Nursing Staff, Hospital/*ethics/*psychology
MH  - United States
EDAT- 2011/04/19 06:00
MHDA- 2011/07/02 06:00
CRDT- 2011/04/19 06:00
PHST- 2011/04/19 06:00 [entrez]
PHST- 2011/04/19 06:00 [pubmed]
PHST- 2011/07/02 06:00 [medline]
PST - ppublish
SO  - Tenn Nurse. 2011 Spring;74(1):1, 4.


PMID- 21495515
OWN - NLM
STAT- MEDLINE
DCOM- 20110513
LR  - 20191112
IS  - 0093-0334 (Print)
IS  - 0093-0334 (Linking)
VI  - 41
IP  - 2
DP  - 2011 Mar-Apr
TI  - Questioning the quantitative imperative: decision aids, prevention, and the
      ethics of disclosure.
PG  - 30-9
AB  - Patients should not always receive hard data about the risks and benefits of a
      medical intervention. That information should always be available to patients who
      expressly ask for it, but it should be part of standard disclosure only
      sometimes, and only for some patients. And even then, we need to think about how 
      to offer it.
FAU - Schwartz, Peter H
AU  - Schwartz PH
AD  - Indiana University Center for Bioethics, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hastings Cent Rep
JT  - The Hastings Center report
JID - 0410447
SB  - IM
CIN - Hastings Cent Rep. 2012 Jan-Feb;42(1):4; author reply 7-8. PMID: 22616384
CIN - Hastings Cent Rep. 2012 Jan-Feb;42(1):4-5; author reply 7-8. PMID: 22616385
CIN - Hastings Cent Rep. 2012 Jan-Feb;42(1):5-6; author reply 7-8. PMID: 22616386
CIN - Hastings Cent Rep. 2012 Jan-Feb;42(1):6-7; author reply 7-8. PMID: 22616387
MH  - Choice Behavior
MH  - *Decision Making
MH  - *Decision Support Techniques
MH  - Educational Status
MH  - Humans
MH  - Informed Consent/*ethics
MH  - *Judgment
MH  - Mathematical Computing
MH  - *Problem Solving
MH  - *Truth Disclosure/ethics
EDAT- 2011/04/19 06:00
MHDA- 2011/05/14 06:00
CRDT- 2011/04/19 06:00
PHST- 2011/04/19 06:00 [entrez]
PHST- 2011/04/19 06:00 [pubmed]
PHST- 2011/05/14 06:00 [medline]
AID - 10.1353/hcr.2011.0029 [doi]
PST - ppublish
SO  - Hastings Cent Rep. 2011 Mar-Apr;41(2):30-9. doi: 10.1353/hcr.2011.0029.


PMID- 21495059
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20211020
IS  - 1097-0258 (Electronic)
IS  - 0277-6715 (Linking)
VI  - 30
IP  - 15
DP  - 2011 Jul 10
TI  - Bias in estimating accuracy of a binary screening test with differential disease 
      verification.
PG  - 1852-64
LID - 10.1002/sim.4232 [doi]
AB  - Sensitivity, specificity, positive and negative predictive value are typically
      used to quantify the accuracy of a binary screening test. In some studies, it may
      not be ethical or feasible to obtain definitive disease ascertainment for all
      subjects using a gold standard test. When a gold standard test cannot be used, an
      imperfect reference test that is less than 100 per cent sensitive and specific
      may be used instead. In breast cancer screening, for example, follow-up for
      cancer diagnosis is used as an imperfect reference test for women where it is not
      possible to obtain gold standard results. This incomplete ascertainment of true
      disease, or differential disease verification, can result in biased estimates of 
      accuracy. In this paper, we derive the apparent accuracy values for studies
      subject to differential verification. We determine how the bias is affected by
      the accuracy of the imperfect reference test, the percent who receive the
      imperfect reference standard test not receiving the gold standard, the prevalence
      of the disease, and the correlation between the results for the screening test
      and the imperfect reference test. It is shown that designs with differential
      disease verification can yield biased estimates of accuracy. Estimates of
      sensitivity in cancer screening trials may be substantially biased. However,
      careful design decisions, including selection of the imperfect reference test,
      can help to minimize bias. A hypothetical breast cancer screening study is used
      to illustrate the problem.
CI  - Copyright (c) 2011 John Wiley & Sons, Ltd.
FAU - Alonzo, Todd A
AU  - Alonzo TA
AD  - Division of Biostatistics, University of Southern California, Keck School of
      Medicine, Arcadia, CA 91006, U.S.A.. talonzo@childrensoncologygroup.org
FAU - Brinton, John T
AU  - Brinton JT
FAU - Ringham, Brandy M
AU  - Ringham BM
FAU - Glueck, Deborah H
AU  - Glueck DH
LA  - eng
GR  - R03 CA136048/CA/NCI NIH HHS/United States
GR  - R03 CA136048-01A1/CA/NCI NIH HHS/United States
GR  - 1R03CA136048-01A1/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110415
PL  - England
TA  - Stat Med
JT  - Statistics in medicine
JID - 8215016
SB  - IM
MH  - Bias
MH  - Biopsy/standards/*statistics & numerical data
MH  - Breast Neoplasms/*diagnosis/epidemiology
MH  - Computer Simulation
MH  - Diagnosis, Differential
MH  - Diagnostic Errors/*statistics & numerical data
MH  - Early Detection of Cancer/methods/standards/statistics & numerical data
MH  - Epidemiologic Research Design
MH  - Female
MH  - Humans
MH  - Mammography/standards/*statistics & numerical data
MH  - Sensitivity and Specificity
PMC - PMC3115446
MID - NIHMS279636
EDAT- 2011/04/16 06:00
MHDA- 2011/10/25 06:00
CRDT- 2011/04/16 06:00
PHST- 2010/06/09 00:00 [received]
PHST- 2011/01/18 00:00 [accepted]
PHST- 2011/04/16 06:00 [entrez]
PHST- 2011/04/16 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
AID - 10.1002/sim.4232 [doi]
PST - ppublish
SO  - Stat Med. 2011 Jul 10;30(15):1852-64. doi: 10.1002/sim.4232. Epub 2011 Apr 15.


PMID- 21493947
OWN - NLM
STAT- MEDLINE
DCOM- 20110712
LR  - 20211020
IS  - 1541-0048 (Electronic)
IS  - 0090-0036 (Linking)
VI  - 101
IP  - 6
DP  - 2011 Jun
TI  - Facilitating HIV disclosure across diverse settings: a review.
PG  - 1011-23
LID - 10.2105/AJPH.2010.300102 [doi]
AB  - HIV status disclosure is central to debates about HIV because of its potential
      for HIV prevention and its links to privacy and confidentiality as human-rights
      issues. Our review of the HIV-disclosure literature found that few people keep
      their status completely secret; disclosure tends to be iterative and to be higher
      in high-income countries; gender shapes disclosure motivations and reactions;
      involuntary disclosure and low levels of partner disclosure highlight the
      difficulties faced by health workers; the meaning and process of disclosure
      differ across settings; stigmatization increases fears of disclosure; and the
      ethical dilemmas resulting from competing values concerning confidentiality
      influence the extent to which disclosure can be facilitated. Our results suggest 
      that structural changes, including making more services available, could
      facilitate HIV disclosure as much as individual approaches and counseling do.
FAU - Obermeyer, Carla Makhlouf
AU  - Obermeyer CM
AD  - Department of HIV/AIDS, World Health Organization, 20 Ave Appia, 1211 Geneva,
      Switzerland. obermeyerc@who.int
FAU - Baijal, Parijat
AU  - Baijal P
FAU - Pegurri, Elisabetta
AU  - Pegurri E
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110414
PL  - United States
TA  - Am J Public Health
JT  - American journal of public health
JID - 1254074
SB  - IM
MH  - Confidentiality
MH  - HIV Infections/prevention & control/*psychology
MH  - Humans
MH  - Interpersonal Relations
MH  - *Professional-Patient Relations
MH  - Socioeconomic Factors
MH  - *Truth Disclosure
PMC - PMC3093267
EDAT- 2011/04/16 06:00
MHDA- 2011/07/13 06:00
CRDT- 2011/04/16 06:00
PHST- 2011/04/16 06:00 [entrez]
PHST- 2011/04/16 06:00 [pubmed]
PHST- 2011/07/13 06:00 [medline]
AID - AJPH.2010.300102 [pii]
AID - 10.2105/AJPH.2010.300102 [doi]
PST - ppublish
SO  - Am J Public Health. 2011 Jun;101(6):1011-23. doi: 10.2105/AJPH.2010.300102. Epub 
      2011 Apr 14.


PMID- 21493945
OWN - NLM
STAT- MEDLINE
DCOM- 20110712
LR  - 20211020
IS  - 1541-0048 (Electronic)
IS  - 0090-0036 (Linking)
VI  - 101
IP  - 6
DP  - 2011 Jun
TI  - A US policy perspective on oral preexposure prophylaxis for HIV.
PG  - 982-5
LID - 10.2105/AJPH.2010.300066 [doi]
AB  - Orally administered preexposure prophylaxis is an innovative and controversial
      HIV prevention strategy involving the regular use of antiretroviral medications
      by uninfected individuals. Antiretroviral medications protect against potential
      HIV infection by reducing susceptibility to the virus. Recent clinical trial
      results indicate that preexposure prophylaxis can be safe and efficacious for men
      who have sexual intercourse with men, yet there remain policy considerations
      surrounding costs, opportunity costs, and ethical issues that must be addressed
      before broad implementation in the United States.
FAU - Leibowitz, Arleen A
AU  - Leibowitz AA
AD  - Department of Public Policy, University of California, Los Angeles School of
      Public Affairs, Los Angeles, CA 90095-1656, USA. arleen@ucla.edu
FAU - Parker, Karen Byrnes
AU  - Parker KB
FAU - Rotheram-Borus, Mary Jane
AU  - Rotheram-Borus MJ
LA  - eng
GR  - P30 MH058107/MH/NIMH NIH HHS/United States
GR  - P30 MH058107-12/MH/NIMH NIH HHS/United States
GR  - P30 MH 58107/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110414
PL  - United States
TA  - Am J Public Health
JT  - American journal of public health
JID - 1254074
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - Administration, Oral
MH  - Anti-HIV Agents/administration & dosage/economics/*therapeutic use
MH  - Bioethical Issues
MH  - Counseling/economics
MH  - HIV Infections/*prevention & control
MH  - *Health Policy
MH  - Health Resources/supply & distribution
MH  - *Homosexuality, Male
MH  - Humans
MH  - Male
MH  - Randomized Controlled Trials as Topic
MH  - United States
PMC - PMC3093264
MID - NIHMS302589
EDAT- 2011/04/16 06:00
MHDA- 2011/07/13 06:00
CRDT- 2011/04/16 06:00
PHST- 2011/04/16 06:00 [entrez]
PHST- 2011/04/16 06:00 [pubmed]
PHST- 2011/07/13 06:00 [medline]
AID - AJPH.2010.300066 [pii]
AID - 10.2105/AJPH.2010.300066 [doi]
PST - ppublish
SO  - Am J Public Health. 2011 Jun;101(6):982-5. doi: 10.2105/AJPH.2010.300066. Epub
      2011 Apr 14.


PMID- 21493153
OWN - NLM
STAT- MEDLINE
DCOM- 20110928
LR  - 20110606
IS  - 1472-6491 (Electronic)
IS  - 1472-6483 (Linking)
VI  - 22
IP  - 7
DP  - 2011 Jun
TI  - Invited commentary on 'Robert G Edwards and the Roman Catholic Church'.
PG  - 661-2
LID - 10.1016/j.rbmo.2011.03.005 [doi]
AB  - The objectification of procreation and its products - i.e. their separation from 
      their normal human context and meaning - is an inevitable consequence of assisted
      reproduction technology. This should be a matter for serious ethical reflection, 
      for we are all diminished if becoming a mother or a father, or carrying a child, 
      or if children themselves are stripped of their profound human meanings.
CI  - Copyright (c) 2011 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All
      rights reserved.
FAU - McGovern, Kevin
AU  - McGovern K
AD  - Caroline Chisholm Centre for Health Ethics, East Melbourne, Victoria 3002,
      Australia.
LA  - eng
PT  - Comment
PT  - Journal Article
DEP - 20110311
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
SB  - IM
CON - Reprod Biomed Online. 2011 Jun;22(7):665-72. PMID: 21498122
MH  - Catholicism
MH  - Humans
MH  - *Religion and Medicine
MH  - Reproductive Techniques, Assisted/*ethics
EDAT- 2011/04/16 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/04/16 06:00
PHST- 2011/02/07 00:00 [received]
PHST- 2011/03/03 00:00 [accepted]
PHST- 2011/04/16 06:00 [entrez]
PHST- 2011/04/16 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - S1472-6483(11)00158-1 [pii]
AID - 10.1016/j.rbmo.2011.03.005 [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2011 Jun;22(7):661-2. doi: 10.1016/j.rbmo.2011.03.005. Epub
      2011 Mar 11.


PMID- 21493149
OWN - NLM
STAT- MEDLINE
DCOM- 20110928
LR  - 20110606
IS  - 1472-6491 (Electronic)
IS  - 1472-6483 (Linking)
VI  - 22
IP  - 7
DP  - 2011 Jun
TI  - The ethical dimension of assisted reproduction technology.
PG  - 655-7
LID - 10.1016/j.rbmo.2011.03.007 [doi]
FAU - Benagiano, Giuseppe
AU  - Benagiano G
LA  - eng
PT  - Editorial
PT  - Introductory Journal Article
DEP - 20110310
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
SB  - IM
MH  - *Catholicism
MH  - Humans
MH  - *Religion and Medicine
MH  - Reproductive Techniques, Assisted/*ethics
EDAT- 2011/04/16 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/04/16 06:00
PHST- 2011/03/03 00:00 [received]
PHST- 2011/03/03 00:00 [accepted]
PHST- 2011/04/16 06:00 [entrez]
PHST- 2011/04/16 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - S1472-6483(11)00160-X [pii]
AID - 10.1016/j.rbmo.2011.03.007 [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2011 Jun;22(7):655-7. doi: 10.1016/j.rbmo.2011.03.007. Epub
      2011 Mar 10.


PMID- 21492397
OWN - NLM
STAT- MEDLINE
DCOM- 20111110
LR  - 20220317
IS  - 1743-6109 (Electronic)
IS  - 1743-6095 (Linking)
VI  - 8
IP  - 6
DP  - 2011 Jun
TI  - Female genital cosmetic and plastic surgery: a review.
PG  - 1813-25
LID - 10.1111/j.1743-6109.2011.02254.x [doi]
AB  - INTRODUCTION: This review studies rationale and outcome of vulvovaginal aesthetic
      surgery. AIM: Discuss procedures designed to alter genital appearance and
      function; investigate sexual, philosophical, and ethical issues; examine
      outcomes. METHODS: (i) Medline search of the existing literature utilizing terms 
      labiaplasty, clitoral hood reduction, hymenoplasty (HP), vaginoplasty (VP),
      perineoplasty (PP), female genital surgery, sexual satisfaction/body image, and
      anterior/posterior colporrhaphy; (ii) references from bibliographies of papers
      found through the literature search and in the author's reading of available
      literature. MAIN OUTCOME MEASURES: (i) Demographics and psychosexual dynamics of 
      women requesting female genital plastic/cosmetic surgery; (ii) overall and sexual
      satisfaction of subjects undergoing these procedures. RESULTS: The majority of
      studies regarding patient satisfaction and sexual function after vaginal
      aesthetic and functional plastic procedures report beneficial results, with
      overall patient satisfaction in the 90-95% range, sexual satisfaction over
      80-85%. These data are supported by outcome data from nonelective vaginal support
      procedures. Complications appear minor and acceptable to patients. There are
      little data available regarding outcomes and satisfaction of HP, or function
      during the rigors of subsequent vaginal childbirth, although the literature
      contains no case reports of labiaplasty disruption during parturition.
      CONCLUSION: Women requesting labiaplasty and reduction of their clitoral hoods do
      so for both cosmetic and functional (chafing, interference with coitus,
      interference with athletic activities, etc.) reasons, while patients requesting
      VP and/or PP do so in order to increase friction and sexual satisfaction,
      occasionally for aesthetic reasons. Patients appear generally happy with
      outcomes. The majority of patients undergoing genital plastic surgery report
      overall satisfaction and subjective enhancement of sexual function and body
      image, but the literature is retrospective. Female genital plastic surgery
      procedures appear to fulfill the majority of patient's desires for cosmetic and
      functional improvement, as well as enhancement of the sexual experience. Little
      information is available regarding HP outcomes.
CI  - (c) 2011 International Society for Sexual Medicine.
FAU - Goodman, Michael P
AU  - Goodman MP
AD  - Caring For Women Wellness Center, Davis, CA 95616, USA.
      michaelgoodman250@gmail.com
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110414
PL  - Netherlands
TA  - J Sex Med
JT  - The journal of sexual medicine
JID - 101230693
SB  - IM
MH  - Adult
MH  - Body Image
MH  - Clitoris/*surgery
MH  - Ethics, Medical
MH  - Female
MH  - Humans
MH  - Patient Satisfaction
MH  - Perineum/*surgery
MH  - Postoperative Complications/etiology
MH  - Reconstructive Surgical Procedures/ethics/*methods
MH  - Sexual Behavior
MH  - Surgical Flaps
MH  - Treatment Outcome
MH  - Vagina/*surgery
MH  - Vulva/*surgery
EDAT- 2011/04/16 06:00
MHDA- 2011/11/11 06:00
CRDT- 2011/04/16 06:00
PHST- 2011/04/16 06:00 [entrez]
PHST- 2011/04/16 06:00 [pubmed]
PHST- 2011/11/11 06:00 [medline]
AID - 10.1111/j.1743-6109.2011.02254.x [doi]
AID - S1743-6095(15)33555-4 [pii]
PST - ppublish
SO  - J Sex Med. 2011 Jun;8(6):1813-25. doi: 10.1111/j.1743-6109.2011.02254.x. Epub
      2011 Apr 14.


PMID- 21489218
OWN - NLM
STAT- MEDLINE
DCOM- 20110831
LR  - 20211020
IS  - 1476-069X (Electronic)
IS  - 1476-069X (Linking)
VI  - 10 Suppl 1
DP  - 2011 Apr 5
TI  - Epidemiology of childhood cancer.
PG  - S8
LID - 10.1186/1476-069X-10-S1-S8 [doi]
AB  - At least in economically developed countries, in the last decades, the incidence 
      of childhood cancer has increased and the increase is unlikely to be an artefact.
      Causes of the increase have not been identified: a role of preventable
      environmental exposures is possible. Changes have also occurred in the age
      distribution of acute lymphoblastic leukaemia.Currently, children with cancer can
      be successfully treated and cured. However, access to the best therapy differs
      widely among countries because of the unequal distribution of resources for
      cancer care. Any double standard in the fate of children with cancer is ethically
      unacceptable.
CI  - (c) 2011 Terracini; licensee BioMed Central Ltd.
FAU - Terracini, Benedetto
AU  - Terracini B
AD  - Center for Cancer Prevention, University of Torino, San Giovanni Battista
      University Hospital, Italy. benedetto.terracini@fastwebnet.it
LA  - eng
PT  - Journal Article
DEP - 20110405
PL  - England
TA  - Environ Health
JT  - Environmental health : a global access science source
JID - 101147645
SB  - IM
MH  - Age Distribution
MH  - Child
MH  - *Environmental Exposure
MH  - Health Services Accessibility/ethics
MH  - Humans
MH  - Incidence
MH  - Neoplasms/*epidemiology/*prevention & control
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/epidemiology
MH  - Socioeconomic Factors
PMC - PMC3073200
EDAT- 2011/04/16 06:00
MHDA- 2011/09/01 06:00
CRDT- 2011/04/15 06:00
PHST- 2011/04/15 06:00 [entrez]
PHST- 2011/04/16 06:00 [pubmed]
PHST- 2011/09/01 06:00 [medline]
AID - 1476-069X-10-S1-S8 [pii]
AID - 10.1186/1476-069X-10-S1-S8 [doi]
PST - epublish
SO  - Environ Health. 2011 Apr 5;10 Suppl 1:S8. doi: 10.1186/1476-069X-10-S1-S8.


PMID- 21489217
OWN - NLM
STAT- MEDLINE
DCOM- 20110831
LR  - 20211020
IS  - 1476-069X (Electronic)
IS  - 1476-069X (Linking)
VI  - 10 Suppl 1
DP  - 2011 Apr 5
TI  - The socioeconomic determinants of cancer.
PG  - S7
LID - 10.1186/1476-069X-10-S1-S7 [doi]
AB  - This paper provides a synthesis on socioeconomic inequalities in cancer
      incidence, mortality and survival across countries and within countries, with
      particular focus on the Italian context; the paper also describes the underlying 
      mechanisms documented for cancer incidence, and reports some remarks on policies 
      to tackle inequalities.From a worldwide perspective, the burden of cancer appears
      to be particularly increasing in developing countries, where many cancers with a 
      poor prognosis (liver, stomach and oesophagus) are much more common than in
      richer countries. As in the case of incidence and mortality, also in cancer
      survival we observe a great variability across countries. Different studies have 
      suggested a possible impact of health care on the social gradients in cancer
      survival, even in countries with a National Health System providing equitable
      access to care.In developed countries, there is increasing awareness of social
      inequalities as an important public health issue; as a consequence, there is a
      variety of strategies and policies being implemented throughout Europe. However, 
      recent reviews emphasize that present knowledge on effectiveness of policies and 
      interventions on health inequalities is not sufficient to offer a robust and
      evidence-based guide to the choice and design of interventions, and that more
      evaluation studies are needed.The large disparities in health that we can measure
      within and between countries represent a challenge to the world; social health
      inequalities are avoidable, and their reduction therefore represents an
      achievable goal and an ethical imperative.
CI  - (c) 2011 Merletti et al; licensee BioMed Central Ltd.
FAU - Merletti, Franco
AU  - Merletti F
AD  - Center for Cancer Prevention, University of Turin, San Giovanni Battista
      University Hospital, Italy. franco.merletti@unito.it
FAU - Galassi, Claudia
AU  - Galassi C
FAU - Spadea, Teresa
AU  - Spadea T
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110405
PL  - England
TA  - Environ Health
JT  - Environmental health : a global access science source
JID - 101147645
SB  - IM
MH  - Developed Countries
MH  - Developing Countries
MH  - Europe/epidemiology
MH  - Female
MH  - Health Policy
MH  - Humans
MH  - Incidence
MH  - Italy/epidemiology
MH  - Male
MH  - Neoplasms/*epidemiology/mortality
MH  - Socioeconomic Factors
PMC - PMC3073199
EDAT- 2011/04/16 06:00
MHDA- 2011/09/01 06:00
CRDT- 2011/04/15 06:00
PHST- 2011/04/15 06:00 [entrez]
PHST- 2011/04/16 06:00 [pubmed]
PHST- 2011/09/01 06:00 [medline]
AID - 1476-069X-10-S1-S7 [pii]
AID - 10.1186/1476-069X-10-S1-S7 [doi]
PST - epublish
SO  - Environ Health. 2011 Apr 5;10 Suppl 1:S7. doi: 10.1186/1476-069X-10-S1-S7.


PMID- 21491611
OWN - NLM
STAT- MEDLINE
DCOM- 20110908
LR  - 20141120
IS  - 1935-9780 (Electronic)
IS  - 1935-9772 (Linking)
VI  - 4
IP  - 3
DP  - 2011 May-Jun
TI  - Body parts removed during surgery: a useful training source.
PG  - 151-6
LID - 10.1002/ase.218 [doi]
AB  - Current undergraduate medical curricula provides relatively little time for
      cadaver dissection. The Department of Human Anatomy and Physiology at the
      University of Padova has organized a pilot project with the University Hospital
      for the donation of body parts that are surgically removed for therapeutic
      purposes and destined under Italian law for destruction. The aim of the project
      is to improve residents' practical training skills. A survey over the last two
      years has shown that about 60 body parts were available each year. These included
      13 upper limbs or their parts (i.e., forearm with hand, hand, and fingers) and 47
      lower limbs or their parts (i.e., legs with feet, feet, or toes). The residents
      explained the aim of the project to potential donors, and, if patients were
      willing to donate, their informed consent was obtained. The residents were
      present in the operating theater during the surgical procedure. In the
      post-operative phase, the same residents performed dissections on the body
      part(s), following a teaching schedule prepared by a clinical anatomist, who also
      assisted residents during their studies. Residents also acted as tutors for
      undergraduate medical students who attended these dissections. The underlying
      pathology for which the body part was removed was examined, and surgical
      procedures were practiced on the body part itself. Our project provided an
      opportunity for a close relationship between anatomists and surgeons, reinforcing
      core knowledge of anatomy by appreciation of its clinical importance. The active 
      involvement of residents as learners and as teachers in the various steps of this
      project improved their knowledge of surgical techniques and helped to establish a
      sense of ethical responsibility and respect for the human body. This approach
      involves study of anatomical structures from new perspectives and leads to
      improved surgical practice.
CI  - Copyright (c) 2011 American Association of Anatomists.
FAU - Macchi, Veronica
AU  - Macchi V
AD  - Department of Human Anatomy and Physiology, Section of Anatomy, University of
      Padova, Padova, Italy.
FAU - Porzionato, Andrea
AU  - Porzionato A
FAU - Stecco, Carla
AU  - Stecco C
FAU - Tiengo, Cesare
AU  - Tiengo C
FAU - Parenti, Anna
AU  - Parenti A
FAU - Cestrone, Adriano
AU  - Cestrone A
FAU - De Caro, Raffaele
AU  - De Caro R
LA  - eng
PT  - Journal Article
DEP - 20110413
PL  - United States
TA  - Anat Sci Educ
JT  - Anatomical sciences education
JID - 101392205
SB  - IM
MH  - Anatomy/*education
MH  - Elective Surgical Procedures
MH  - Ethics Committees
MH  - Hospitals, University
MH  - Pilot Projects
MH  - Serologic Tests
MH  - *Tissue and Organ Harvesting
MH  - *Tissue and Organ Procurement
EDAT- 2011/04/15 06:00
MHDA- 2011/09/09 06:00
CRDT- 2011/04/15 06:00
PHST- 2011/02/08 00:00 [received]
PHST- 2011/03/04 00:00 [revised]
PHST- 2011/03/16 00:00 [accepted]
PHST- 2011/04/15 06:00 [entrez]
PHST- 2011/04/15 06:00 [pubmed]
PHST- 2011/09/09 06:00 [medline]
AID - 10.1002/ase.218 [doi]
PST - ppublish
SO  - Anat Sci Educ. 2011 May-Jun;4(3):151-6. doi: 10.1002/ase.218. Epub 2011 Apr 13.


PMID- 21491211
OWN - NLM
STAT- MEDLINE
DCOM- 20110729
LR  - 20180802
IS  - 1424-3997 (Electronic)
IS  - 0036-7672 (Linking)
VI  - 141
DP  - 2011
TI  - Life-extension: a biomedical goal? Scientific prospects, ethical concerns.
PG  - w13181
LID - 10.4414/smw.2011.13181 [doi]
LID - 2011;141:w13181 [pii]
AB  - The potential for development of biomedical technologies capable of extending the
      human lifespan raises at least two kinds of question that it is important both to
      distinguish and to connect with one another: scientific, factual questions
      regarding the feasibility of life extension interventions; and questions
      concerning the ethical issues related to the extension of life- and healthspans. 
      This paper provides an account of some life extension interventions considered to
      be amongst the most promising, and presents the ethical questions raised by the
      prospect of their pursuit. It is suggested that problems concerning the effects
      of these technologies on health care resources and on intergenerational
      relationships will be the most difficult to tackle.
FAU - Barazzetti, Gaia
AU  - Barazzetti G
AD  - Plateforme Ethos, University of Lausanne, Switzerland. Gaia.Barazzetti@unil.ch
FAU - Reichlin, Massimo
AU  - Reichlin M
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110413
PL  - Switzerland
TA  - Swiss Med Wkly
JT  - Swiss medical weekly
JID - 100970884
SB  - IM
MH  - Aging/physiology
MH  - Biomedical Technology/*ethics
MH  - Humans
MH  - *Life Expectancy
EDAT- 2011/04/15 06:00
MHDA- 2011/07/30 06:00
CRDT- 2011/04/15 06:00
PHST- 2011/04/15 06:00 [entrez]
PHST- 2011/04/15 06:00 [pubmed]
PHST- 2011/07/30 06:00 [medline]
AID - smw-13181 [pii]
AID - 10.4414/smw.2011.13181 [doi]
PST - epublish
SO  - Swiss Med Wkly. 2011 Apr 13;141:w13181. doi: 10.4414/smw.2011.13181. eCollection 
      2011.


PMID- 21489908
OWN - NLM
STAT- MEDLINE
DCOM- 20110722
LR  - 20110524
IS  - 1167-1122 (Print)
IS  - 1167-1122 (Linking)
VI  - 21
IP  - 2
DP  - 2011 Mar-Apr
TI  - Spitzoid melanoma and micrometastases in two lymph node regions: a critical
      situation.
PG  - 229-33
LID - 10.1684/ejd.2010.1238 [doi]
AB  - Atypical Spitz tumors can hardly be differentiated from spitzoid melanoma. CGH
      might help in the differential diagnosis. An 8 year old child with an atypical
      Spitz tumor (with a CGH pattern compatible with melanoma) of 8.0 mm Breslow
      thickness and micrometastases in two lymph node regions was seen at our
      department. The management and prognosis of atypical Spitz tumors is
      controversial, and aggressive procedural steps similar to melanoma are usually
      not recommended. Even performing sentinel lymph node biopsy has been questioned. 
      After extensive interdisciplinary consultations, we did not recommend resection
      of both lymph node regions and chose instead to follow-up with regular whole-body
      MRI and adjuvant treatment with pegylated interferon. Treatment decisions for
      atypical Spitz tumors are a major medical and ethical challenge due to the
      limited available data.
FAU - Navarini, Alexander A
AU  - Navarini AA
AD  - Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, 8091
      Zurich, Switzerland.
FAU - Bauer, Jurgen
AU  - Bauer J
FAU - Barysch, Marjam J
AU  - Barysch MJ
FAU - Kempf, Werner
AU  - Kempf W
FAU - Mihic-Probst, Daniela
AU  - Mihic-Probst D
FAU - Kerl, Katrin
AU  - Kerl K
FAU - Kamarashev, Jivko
AU  - Kamarashev J
FAU - Giovanoli, Pietro
AU  - Giovanoli P
FAU - Kolios, Antonios G A
AU  - Kolios AG
FAU - Bergstraesser, Eva
AU  - Bergstraesser E
FAU - Dummer, Reinhard
AU  - Dummer R
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - Eur J Dermatol
JT  - European journal of dermatology : EJD
JID - 9206420
SB  - IM
MH  - Child
MH  - Comparative Genomic Hybridization
MH  - DNA Copy Number Variations
MH  - Humans
MH  - Lymphatic Metastasis
MH  - Melanoma/genetics/*pathology/therapy
MH  - Nevus, Epithelioid and Spindle Cell/genetics/*pathology/therapy
MH  - Skin Neoplasms/genetics/*pathology/therapy
EDAT- 2011/04/15 06:00
MHDA- 2011/07/23 06:00
CRDT- 2011/04/15 06:00
PHST- 2011/04/15 06:00 [entrez]
PHST- 2011/04/15 06:00 [pubmed]
PHST- 2011/07/23 06:00 [medline]
AID - ejd.2010.1238 [pii]
AID - 10.1684/ejd.2010.1238 [doi]
PST - ppublish
SO  - Eur J Dermatol. 2011 Mar-Apr;21(2):229-33. doi: 10.1684/ejd.2010.1238.


PMID- 21489644
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20220310
IS  - 1873-3735 (Electronic)
IS  - 0165-6147 (Linking)
VI  - 32
IP  - 6
DP  - 2011 Jun
TI  - India's growing participation in global clinical trials.
PG  - 327-9
LID - 10.1016/j.tips.2011.02.017 [doi]
AB  - Lower operational costs, recent regulatory reforms and several logistic
      advantages make India an attractive destination for conducting clinical trials.
      Efforts for maintaining stringent ethical standards and the launch of
      Pharmacovigilance Program of India are expected to maximize the potential of the 
      country for clinical research.
CI  - Copyright (c) 2011. Published by Elsevier Ltd.
FAU - Gupta, Yogendra K
AU  - Gupta YK
AD  - Department of Pharmacology, All India Institute of Medical Sciences, New Delhi
      110029, India.
FAU - Padhy, Biswa M
AU  - Padhy BM
LA  - eng
PT  - Journal Article
DEP - 20110412
PL  - England
TA  - Trends Pharmacol Sci
JT  - Trends in pharmacological sciences
JID - 7906158
SB  - IM
MH  - *Biomedical Research/economics/ethics/trends
MH  - Clinical Trials as Topic/*economics/*ethics/trends
MH  - Commerce/economics/trends
MH  - Drug Industry/*economics/organization & administration/trends
MH  - Humans
MH  - India
MH  - Informed Consent/ethics/legislation & jurisprudence
MH  - International Cooperation
MH  - Outsourced Services/*economics/ethics/trends
EDAT- 2011/04/15 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/04/15 06:00
PHST- 2010/12/02 00:00 [received]
PHST- 2011/02/11 00:00 [revised]
PHST- 2011/02/15 00:00 [accepted]
PHST- 2011/04/15 06:00 [entrez]
PHST- 2011/04/15 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - S0165-6147(11)00041-1 [pii]
AID - 10.1016/j.tips.2011.02.017 [doi]
PST - ppublish
SO  - Trends Pharmacol Sci. 2011 Jun;32(6):327-9. doi: 10.1016/j.tips.2011.02.017. Epub
      2011 Apr 12.


PMID- 21489244
OWN - NLM
STAT- MEDLINE
DCOM- 20120927
LR  - 20211020
IS  - 1757-6512 (Electronic)
IS  - 1757-6512 (Linking)
VI  - 2
IP  - 2
DP  - 2011 Apr 13
TI  - Gene expression changes with differentiation of cord blood stem cells to
      respiratory epithelial cells: a preliminary observation.
PG  - 19
LID - 10.1186/scrt60 [doi]
AB  - INTRODUCTION: Owing to wide availability, low cost and avoidance of ethical
      concerns, umbilical cord blood (UCB) provides an attractive source of stem cells 
      for investigational and therapeutic uses. In this study, we sought to
      characterize the gene expression changes as stem cells from UCB differentiate
      toward alveolar type II pneumocytes (ATII). METHODS: Control and experimental
      cells were cultured in maintenance medium (mesenchymal stem cell growth medium)
      or differentiation medium (small airway growth medium (SAGM)), respectively, for 
      8 days. Total RNA was isolated from control and experimental groups for gene
      expression profiling and real-time polymerase chain reaction assay. RESULTS:
      Analysis of only mixed cell lines (n = 2) with parameters including a P value of 
      0.01 and an intergroup gap of 2.0 yielded a set of 373 differentially expressed
      genes. Prominently upregulated genes included several genes associated with ATII 
      cells and also lung cancers: ALDH3A1, VDR and CHKA. Several upregulated genes
      have been shown to be integral or related to ATII functioning: SGK1, HSD17B11 and
      LEPR. Finally, several upregulated genes appear to play a role in lung cancers,
      including FDXR and GP96. Downregulated genes appear to be associated with bone,
      muscle and central nervous system tissues as well as other widespread tissues.
      CONCLUSIONS: To the best of our knowledge, this accounting of the gene expression
      changes associated with the differentiation of a human UCB-derived stem cell
      toward an ATII cell represents the first such effort. Dissecting which components
      of SAGM affect specific gene regulation events is warranted.
FAU - Berger, Michael J
AU  - Berger MJ
AD  - Department of Laboratory Medicine and Pathology, University of Minnesota, 420
      Delaware Street SE, MMC609, Minneapolis, MN 5545, USA. berg0754@umn.edu
FAU - Minnerath, Sharon R
AU  - Minnerath SR
FAU - Adams, Sheryl D
AU  - Adams SD
FAU - Tigges, Barbara M
AU  - Tigges BM
FAU - Sprague, Stacey L
AU  - Sprague SL
FAU - McKenna, David H Jr
AU  - McKenna DH Jr
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110413
PL  - England
TA  - Stem Cell Res Ther
JT  - Stem cell research & therapy
JID - 101527581
SB  - IM
MH  - Cell Differentiation
MH  - Cells, Cultured
MH  - Down-Regulation
MH  - Epithelial Cells/cytology/*metabolism
MH  - Fetal Blood/*cytology
MH  - Gene Expression Profiling
MH  - Humans
MH  - Lung Neoplasms/genetics/metabolism
MH  - Stem Cells/*cytology
MH  - Up-Regulation
PMC - PMC3226290
GN  - NLM: Original DateCompleted: 20111110
EDAT- 2011/04/15 06:00
MHDA- 2011/04/15 06:01
CRDT- 2011/04/15 06:00
PHST- 2011/01/10 00:00 [received]
PHST- 2011/03/17 00:00 [revised]
PHST- 2011/04/13 00:00 [accepted]
PHST- 2011/04/15 06:00 [entrez]
PHST- 2011/04/15 06:00 [pubmed]
PHST- 2011/04/15 06:01 [medline]
AID - scrt60 [pii]
AID - 10.1186/scrt60 [doi]
PST - epublish
SO  - Stem Cell Res Ther. 2011 Apr 13;2(2):19. doi: 10.1186/scrt60.


PMID- 21488560
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20181201
IS  - 0748-8157 (Print)
IS  - 0748-8157 (Linking)
VI  - 27
IP  - 3
DP  - 2011 Spring
TI  - Ethical issues arising from variation in health services utilization at the end
      of life.
PG  - 17-26
AB  - Research on health services delivery, particularly at the end of life, has
      demonstrated that more care does not necessarily lead to better technical
      quality, patient satisfaction, or outcomes. These findings raise three ethical
      issues: (1) justice in the allocation of scarce resources across health service
      areas; (2) nonmaleficence in the provision of appropriate amounts of care to
      patients; and (3) transparency about local healthcare practice so patients can
      make enlightened decisions about healthcare choices. We conclude that in this era
      of healthcare accountability, managers and clinicians can use these ethical
      principles to drive change in the process of providing more efficient, more
      effective, and more patient-centered care, especially at the end of life.
FAU - Weeks, William Brinson
AU  - Weeks WB
AD  - Dartmouth Institute for Health Policy and Clinical Practice, USA.
FAU - Nelson, William A
AU  - Nelson WA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Front Health Serv Manage
JT  - Frontiers of health services management
JID - 8501389
CIN - Front Health Serv Manage. 2011 Spring;27(3):27-33. PMID: 21488561
CIN - Front Health Serv Manage. 2011 Spring;27(3):35-41. PMID: 21488562
CIN - Front Health Serv Manage. 2011 Spring;27(3):43-8. PMID: 21488563
MH  - Beneficence
MH  - Decision Making
MH  - Health Resources
MH  - Health Services Research
MH  - Humans
MH  - Informed Consent
MH  - Medicare
MH  - Palliative Care/economics/ethics/statistics & numerical data
MH  - Terminal Care/*economics/*ethics/*statistics & numerical data
MH  - United States
EDAT- 2011/04/15 06:00
MHDA- 2011/06/03 06:00
CRDT- 2011/04/15 06:00
PHST- 2011/04/15 06:00 [entrez]
PHST- 2011/04/15 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
PST - ppublish
SO  - Front Health Serv Manage. 2011 Spring;27(3):17-26.


PMID- 21488517
OWN - NLM
STAT- MEDLINE
DCOM- 20110513
LR  - 20180831
IS  - 0002-9564 (Print)
IS  - 0002-9564 (Linking)
VI  - 65
IP  - 1
DP  - 2011
TI  - Ethics in practice: a critical appreciation of Mikhail Bakhtin's concept of
      "outsideness" in relation to responsibility and the creation of meaning in
      psychotherapy.
PG  - 1-25
AB  - High standards of ethical practice are paramount in psychotherapy and involve the
      negotiation of complex issues in societies characterised by ethnic, cultural and 
      religious diversity. Bakhtin's concept of "outsideness" offers a potential way of
      thinking about the ethical implications of therapist interventions that is
      transtheoretical and that pays particular attention to the use of language and
      the embodied nature of human interaction.
FAU - Pollard, Rachel
AU  - Pollard R
AD  - United Kingdom Council for Psychotherapy (UKCP), Association for Cognitive
      Analytic Therapy (ACAT), London, UK. Psypracticewc1@Goolgemail.Com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Psychother
JT  - American journal of psychotherapy
JID - 0110672
SB  - IM
MH  - Humans
MH  - Professional-Patient Relations/*ethics
MH  - Psychotherapy/*ethics
EDAT- 2011/04/15 06:00
MHDA- 2011/05/14 06:00
CRDT- 2011/04/15 06:00
PHST- 2011/04/15 06:00 [entrez]
PHST- 2011/04/15 06:00 [pubmed]
PHST- 2011/05/14 06:00 [medline]
AID - 10.1176/appi.psychotherapy.2011.65.1.1 [doi]
PST - ppublish
SO  - Am J Psychother. 2011;65(1):1-25. doi: 10.1176/appi.psychotherapy.2011.65.1.1.


PMID- 21487542
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 2158-8341 (Electronic)
IS  - 2158-8333 (Linking)
VI  - 8
IP  - 3
DP  - 2011 Mar
TI  - Five skills psychiatrists should have in order to provide patients with optimal
      ethical care.
PG  - 19-25
AB  - Analyses of empirical research and ethical problems require different skills and 
      approaches. This article presents five core skills psychiatrists need to be able 
      to address ethical problems optimally. These include their being able to
      recognize ethical conflicts and distinguish them from empirical questions, apply 
      all morally relevant values, and know good from bad ethical arguments. Clinical
      examples of each are provided.
FAU - Howe, Edmund
AU  - Howe E
AD  - Dr. Howe is Professor, Department of Psychiatry, Director, Programs in Medical
      Ethics, and Senior Scientist, Center for the Study of Traumatic Stress, Uniformed
      Services University of the Health Sciences, Bethesda, Maryland.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Innov Clin Neurosci
JT  - Innovations in clinical neuroscience
JID - 101549695
PMC - PMC3074197
OTO - NOTNLM
OT  - Ethics
OT  - advance directives
OT  - autonomy
OT  - cancer
OT  - caregivers
OT  - cholinesterase inhibitors
OT  - confidentiality
OT  - dementia
OT  - genetics
OT  - memory
OT  - mental status exam
OT  - minimal cognitive impairment
OT  - research
OT  - suicide
EDAT- 2011/04/14 06:00
MHDA- 2011/04/14 06:01
CRDT- 2011/04/14 06:00
PHST- 2011/04/14 06:00 [entrez]
PHST- 2011/04/14 06:00 [pubmed]
PHST- 2011/04/14 06:01 [medline]
PST - ppublish
SO  - Innov Clin Neurosci. 2011 Mar;8(3):19-25.


PMID- 21487211
OWN - NLM
STAT- MEDLINE
DCOM- 20120123
LR  - 20211020
IS  - 1662-8063 (Electronic)
IS  - 1662-4246 (Linking)
VI  - 14
IP  - 6
DP  - 2011
TI  - Attitudes toward genetic research review: results from a survey of human genetics
      researchers.
PG  - 337-45
LID - 10.1159/000324931 [doi]
AB  - BACKGROUND: Researchers often relate personal experiences of difficulties and
      challenges with Institutional Review Board (IRB) review of their human genetic
      research protocols. However, there have been no studies that document the range
      and frequency of these concerns among researchers conducting human
      genetic/genomic studies. METHODS: An online anonymous survey was used to collect 
      information from human genetic researchers regarding views about IRB review of
      genetic protocols. Logistic regression was used to test specific hypotheses.
      Results from the national online survey of 351 human genomic researchers are
      summarized in this report. RESULTS: Issues involving considerable discussion with
      IRBs included reconsent of subjects (51%), protection of participants' personal
      information (39%) and return of results to participants (34%). Over half of the
      participants had experienced one or more negative consequences of the IRB review 
      process and approximately 25% had experienced one or more positive consequences. 
      Respondents who had served on an IRB were about 80% more likely to report
      positive consequences of IRB review than their colleagues who had never served on
      an IRB (p = 0.03). Survey responses were mixed on the need for reconsent before
      data sharing and risks related to participant reidentification from genomic data.
      CONCLUSION: The results from this study provide important perspectives of
      researchers regarding genetic research review and show lack of consensus on key
      research ethics issues in genomic research.
CI  - Copyright (c) 2011 S. Karger AG, Basel.
FAU - Edwards, K L
AU  - Edwards KL
AD  - Department of Epidemiology, University of Washington, Seattle, WA 98115, USA.
      keddy@uw.edu
FAU - Lemke, A A
AU  - Lemke AA
FAU - Trinidad, S B
AU  - Trinidad SB
FAU - Lewis, S M
AU  - Lewis SM
FAU - Starks, H
AU  - Starks H
FAU - Quinn Griffin, M T
AU  - Quinn Griffin MT
FAU - Wiesner, G L
AU  - Wiesner GL
LA  - eng
GR  - P50 HG003374/HG/NHGRI NIH HHS/United States
GR  - P50 HG003390/HG/NHGRI NIH HHS/United States
GR  - R01 CA149051/CA/NCI NIH HHS/United States
GR  - U01 HG004609/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110411
PL  - Switzerland
TA  - Public Health Genomics
JT  - Public health genomics
JID - 101474167
SB  - IM
MH  - *Attitude
MH  - Bioethics
MH  - Confidentiality
MH  - Data Collection
MH  - *Ethics Committees, Research
MH  - Female
MH  - Genetic Research/*ethics
MH  - Genetics/*trends
MH  - Genomics
MH  - Humans
MH  - *Informed Consent
MH  - Male
MH  - Privacy
MH  - Regression Analysis
MH  - Research Personnel
MH  - Software
PMC - PMC3221257
EDAT- 2011/04/14 06:00
MHDA- 2012/01/24 06:00
CRDT- 2011/04/14 06:00
PHST- 2010/02/08 00:00 [received]
PHST- 2011/02/04 00:00 [accepted]
PHST- 2011/04/14 06:00 [entrez]
PHST- 2011/04/14 06:00 [pubmed]
PHST- 2012/01/24 06:00 [medline]
AID - 000324931 [pii]
AID - 10.1159/000324931 [doi]
PST - ppublish
SO  - Public Health Genomics. 2011;14(6):337-45. doi: 10.1159/000324931. Epub 2011 Apr 
      11.


PMID- 21487119
OWN - NLM
STAT- MEDLINE
DCOM- 20110512
LR  - 20110429
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Linking)
VI  - 332
IP  - 6029
DP  - 2011 Apr 29
TI  - Ethics. Ethical framework for biofuels.
PG  - 540-1
LID - 10.1126/science.1206064 [doi]
FAU - Buyx, Alena
AU  - Buyx A
AD  - Nuffield Council on Bioethics, London WC1B 3JS, UK. abuyx@nuffieldbioethics.org
FAU - Tait, Joyce
AU  - Tait J
LA  - eng
PT  - Journal Article
DEP - 20110412
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Biofuels)
SB  - IM
MH  - Biodiversity
MH  - *Biofuels/economics
MH  - Climate Change
MH  - Conservation of Natural Resources
MH  - Costs and Cost Analysis
MH  - Ecosystem
MH  - *Ethics
MH  - Greenhouse Effect
MH  - Human Rights
MH  - Humans
MH  - Intellectual Property
MH  - International Cooperation
MH  - *Policy
MH  - Policy Making
MH  - Research
MH  - Salaries and Fringe Benefits
EDAT- 2011/04/14 06:00
MHDA- 2011/05/13 06:00
CRDT- 2011/04/14 06:00
PHST- 2011/04/14 06:00 [entrez]
PHST- 2011/04/14 06:00 [pubmed]
PHST- 2011/05/13 06:00 [medline]
AID - science.1206064 [pii]
AID - 10.1126/science.1206064 [doi]
PST - ppublish
SO  - Science. 2011 Apr 29;332(6029):540-1. doi: 10.1126/science.1206064. Epub 2011 Apr
      12.


PMID- 21486622
OWN - NLM
STAT- MEDLINE
DCOM- 20110729
LR  - 20220408
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 43
IP  - 3
DP  - 2011 Apr
TI  - Bispectral index monitoring to guide end-tidal isoflurane concentration at three 
      phases of operation in patients with end-stage liver disease undergoing
      orthotopic liver transplantation.
PG  - 892-5
LID - 10.1016/j.transproceed.2010.11.023 [doi]
AB  - It has been shown that anesthetic requirements during liver transplantation are
      inversely proportional to the degree of hepatic dysfunction. We investigate
      alterations during the three phases of requirements for intraoperative isoflurane
      within the target of 40 to 55 Bispectral Index (BIS) values concerning patients
      with end-stage liver disease who are undergoing liver transplantation. After
      faculty ethics committee approval, we studied 50 patients of (age range, 18 to 65
      years) who were undergoing liver transplantation. After induction, we used
      isoflurane with air/oxygen (FiO(2) = 0.5%) for anesthetic maintenance. The
      isoflurane concentration was set within the range of 40 to 55 BIS values.
      Remifentanil (0.15 mug/kg/min) was infused for analgesia and cisatracurium was
      administered via continuous infusion. After anesthetic induction, we inserted
      arterial, pulmonary artery, and central venous catheters. The heart rate, mean
      arterial pressure (MAP), mean pulmonary arterial pressure (MPAP), body
      temperature, BIS values, end-tidal isoflurane concentration (ETiso) and end-tidal
      carbon dioxide concentration (ETCO(2)) were recorded at 30-minute intervals
      during the dissection and neohepatic phases, at 15-minute intervals during the
      anhepatic phase. In addition, we calculated the cardiac index during the three
      phases. There was no difference in heart rates among the operative phases. In
      contrast, there were significant changes in MAP, MPAP, BIS, ETCO(2) and body
      temperature values. However, all of these parameters were in physiological ranges
      and clinically acceptable. The ETiso values were lowest in the anhepatic phase
      compared to other phases, but the differences were not clinically important. The 
      ETiso values in the dissection and neohepatic phases were compared with the
      anhepatic phase higher 5% and 8.6% respectively. During liver transplantation,
      ETiso requirement for the anhepatic phase was lower compared with the other two
      phases within the range of 40 to 55 BIS values.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Toprak, H I
AU  - Toprak HI
AD  - Department of Anesthesiology, Medical School of Inonu University, Malatya,
      Turkey. hilksen@inonu.edu.tr
FAU - Sener, A
AU  - Sener A
FAU - Gedik, E
AU  - Gedik E
FAU - Ucar, M
AU  - Ucar M
FAU - Karahan, K
AU  - Karahan K
FAU - Aydogan, M S
AU  - Aydogan MS
FAU - Ersoy, M O
AU  - Ersoy MO
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - 0 (Anesthetics, Inhalation)
RN  - CYS9AKD70P (Isoflurane)
SB  - IM
MH  - Adult
MH  - Anesthetics, Inhalation/*administration & dosage
MH  - End Stage Liver Disease/*surgery
MH  - Female
MH  - Humans
MH  - Isoflurane/*administration & dosage
MH  - Liver Transplantation/*methods
MH  - Male
MH  - Middle Aged
MH  - Monitoring, Physiologic/*methods
EDAT- 2011/04/14 06:00
MHDA- 2011/07/30 06:00
CRDT- 2011/04/14 06:00
PHST- 2011/04/14 06:00 [entrez]
PHST- 2011/04/14 06:00 [pubmed]
PHST- 2011/07/30 06:00 [medline]
AID - S0041-1345(10)01730-6 [pii]
AID - 10.1016/j.transproceed.2010.11.023 [doi]
PST - ppublish
SO  - Transplant Proc. 2011 Apr;43(3):892-5. doi: 10.1016/j.transproceed.2010.11.023.


PMID- 21486600
OWN - NLM
STAT- MEDLINE
DCOM- 20110729
LR  - 20110413
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 43
IP  - 3
DP  - 2011 Apr
TI  - Exchange donor transplantation: ethical option for living renal transplantation.
PG  - 795-7
LID - 10.1016/j.transproceed.2010.11.022 [doi]
AB  - PURPOSE: Taking in consideration the opinion of our team, which necessitates
      obligation of a relative relation between donors and recipients (genetic or
      matrimonial), we performed donor exchanges as an ethical alternative in living
      donor transplantations. We reviewed the outcomes of our exchange series. METHODS:
      Between July 2003 and August 2010 we performed 110 exchange donor
      transplantations in four hospitals: one four-way, two three-way, and 100 two-way 
      cases. Donors were mostly spouses (n = 71) or mothers (n = 15). The mean age of
      the donors was 48.8 (range = 23-69) and the recipients 41.4 years (range = 5-66).
      Two were transplanted preemptively and the others had a mean dialysis duration of
      43 months (range = 1-120). RESULTS: Among 110 patients, three compatible pairs
      joined the group voluntarily; 71, due to ABO incompatibility and 36, due to
      crossmatch positivity. Induction therapy was used in 92 patients. HLA mismatches 
      (MM) were: one MM in three; two MM in three; three MM in 18, four MM in 36; five 
      MM in 34; and six MM in 18. Among 90 patients tested for panel-reactive
      antibodies PRA, five showed class I and 10, class II positivity. In 11 patients, 
      B-cell positivity was detected by flow cytometry. Delayed graft function (n = 2),
      acute rejection (n = 11), BK virus infection (n = 1), and cytomegalovirus
      infection (n = 3) were seen postoperatively. Three (2.7%) patients died due to
      sepsis. Five patients returned to dialysis program due to interstitial fibrosis
      tubular atrophy (IFTA) (n = 2), renal vein thrombosis (n = 1), de novo
      glomerulopathy (n = 1), or primary nonfunction (n = 1). The 1- and 5-year patient
      and graft survival rates were 96% and 96%, 95% and 89%, respectively. CONCLUSION:
      We believe that exchange donor transplantation is as successful as direct
      transplants; it is a good, ethical alternative to unrelated living
      transplantations.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Gurkan, A
AU  - Gurkan A
AD  - Gaziosmanpasa Hospital, Istanbul, Turkey. alpgurkan@superonline.com
FAU - Kacar, S
AU  - Kacar S
FAU - Varilsuha, C
AU  - Varilsuha C
FAU - Tilif, S
AU  - Tilif S
FAU - Turunc, V
AU  - Turunc V
FAU - Dogan, M
AU  - Dogan M
FAU - Dheir, H
AU  - Dheir H
FAU - Sahin, S
AU  - Sahin S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Ethics
MH  - Family
MH  - Female
MH  - Histocompatibility Testing
MH  - Humans
MH  - *Kidney Transplantation
MH  - *Living Donors
MH  - Male
MH  - Middle Aged
EDAT- 2011/04/14 06:00
MHDA- 2011/07/30 06:00
CRDT- 2011/04/14 06:00
PHST- 2011/04/14 06:00 [entrez]
PHST- 2011/04/14 06:00 [pubmed]
PHST- 2011/07/30 06:00 [medline]
AID - S0041-1345(10)01729-X [pii]
AID - 10.1016/j.transproceed.2010.11.022 [doi]
PST - ppublish
SO  - Transplant Proc. 2011 Apr;43(3):795-7. doi: 10.1016/j.transproceed.2010.11.022.


PMID- 21486579
OWN - NLM
STAT- MEDLINE
DCOM- 20110729
LR  - 20110413
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 43
IP  - 3
DP  - 2011 Apr
TI  - Preoperative natriuretic peptide-B values and ascites in male liver transplant
      recipients.
PG  - 705-7
LID - 10.1016/j.transproceed.2011.01.086 [doi]
AB  - Plasma preoperative values of natriuretic B peptide (pro-BNP) were correlated
      with ascites in men experiencing hepatic cirrhosis due to different etiologies on
      the active waiting list for liver transplantation. The study was performed in 54 
      male recipients of a liver transplant. Written informed consent was obtained from
      the patients or their relatives, and the study protocol was approved by our local
      Clinical Research (Ethics) Committee. Male patients were classified into two
      groups: group 1 included patients with alcoholic hepatic cirrhosis (n = 30)
      distributed as 19 men with no ascites, four with nonrefractory ascites, and seven
      with refractory ascites; group 2 included cases of viral hepatitis cirrhosis (n =
      24) distributed as 13 men with no ascites, nine with non-refractory ascites, and 
      two with refractory ascites. A group of six healthy male volunteers was used to
      establish normal (basal) values of pro-BNP and left auricular diameter (LAD).
      Pro-BNP values were determined in plasma samples by an electrochemiluminiscence
      immunoassay. Pro-BNP plasma levels in patients with alcoholic cirrhosis were
      threefold greater among patients with no ascites or no refractory ascites
      compared with healthy men, whereas pro-BNP values were fivefold enhanced among
      alcoholic patients with refractory ascites. The viral hepatitis cirrhosis group
      showed pro-BNP plasma values 1.5-fold enhanced in men with no ascites, whereas
      pro-BNP reached fivefold with either nonrefractory or refractory ascites. The
      enhanced pro-BNP plasma levels indicated advanced hepatic degradation, seemingly 
      related to the presence of refractory ascites associated with cirrhosis.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Espinosa, M-D
AU  - Espinosa MD
AD  - Virgen de las Nieves University Hospital, Granada, Spain.
FAU - Olmedo, C
AU  - Olmedo C
FAU - Muffak-Granero, K
AU  - Muffak-Granero K
FAU - Comino, A
AU  - Comino A
FAU - Nogueras, M-F
AU  - Nogueras MF
FAU - Villegas, M-T
AU  - Villegas MT
FAU - Becerra, A
AU  - Becerra A
FAU - Garrote, D
AU  - Garrote D
FAU - Bueno, P
AU  - Bueno P
FAU - Ferron, J-A
AU  - Ferron JA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Ascites/*blood
MH  - Humans
MH  - Immunoassay/methods
MH  - *Liver Transplantation
MH  - Luminescence
MH  - Male
MH  - Natriuretic Peptide, Brain/*blood
MH  - Preoperative Period
EDAT- 2011/04/14 06:00
MHDA- 2011/07/30 06:00
CRDT- 2011/04/14 06:00
PHST- 2011/04/14 06:00 [entrez]
PHST- 2011/04/14 06:00 [pubmed]
PHST- 2011/07/30 06:00 [medline]
AID - S0041-1345(11)00170-9 [pii]
AID - 10.1016/j.transproceed.2011.01.086 [doi]
PST - ppublish
SO  - Transplant Proc. 2011 Apr;43(3):705-7. doi: 10.1016/j.transproceed.2011.01.086.


PMID- 21486543
OWN - NLM
STAT- MEDLINE
DCOM- 20110623
LR  - 20110413
IS  - 0948-6259 (Print)
IS  - 0948-6259 (Linking)
VI  - 25
IP  - 1
DP  - 2011
TI  - [Coercion in Psychiatry - a taboo?].
PG  - 44-50
AB  - History shows that the discussion concerning coercive measures against mentally
      ill is as old as psychiatry itself. The dilemma of psychiatry lies in its double 
      role - having both a therapeutic and a regulatory function. Violence against sick
      and disabled people conflicts with the ethical principles of helping professions.
      This, however, is where the danger lies: that the violent parts of psychiatric
      work - which in the opinion of experts cannot be entirely avoided - are repressed
      or seen as taboo and are therefore more difficult to control. Comparisons between
      EU countries of the nature, frequency and duration of coercive measures are
      difficult because of the heterogeneity of regulation and differences in
      established practice. Scientific examination of this issue seems to be
      insufficient. There are only a few studies on important issues such as how
      patients rate these measures. An open and thorough debate about the meaning and
      meaninglessness of coercion and violence in psychiatric treatment would be
      necessary to prevent "routine violence" or the excessive use of force against the
      mentally ill.
FAU - Meise, Ullrich
AU  - Meise U
AD  - Gesellschaft fur Psychische Gesundheit - pro mente tirol, Innsbruck.
      meise.u@gpg-tirol.at
FAU - Frajo-Apor, Beatrice
AU  - Frajo-Apor B
FAU - Stippler, Stippler
AU  - Stippler S
FAU - Wancata, Johannes
AU  - Wancata J
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Zwangsmassnahmen in der Psychiatrie - ein Tabu?
PL  - Germany
TA  - Neuropsychiatr
JT  - Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der
      Gesellschaft Osterreichischer Nervenarzte und Psychiater
JID - 9440588
RN  - 0 (Psychotropic Drugs)
SB  - IM
MH  - Adaptation, Psychological/ethics
MH  - Austria
MH  - *Coercion
MH  - Commitment of Mentally Ill
MH  - Humans
MH  - Mental Disorders/psychology/*therapy
MH  - Paternalism/ethics
MH  - Patient Isolation/ethics
MH  - Patient Satisfaction
MH  - Personal Autonomy
MH  - Professional-Patient Relations/ethics
MH  - Psychotropic Drugs/therapeutic use
MH  - Restraint, Physical/ethics
MH  - Self Concept
MH  - Taboo/*psychology
MH  - Treatment Refusal/ethics
MH  - Violence/*ethics
EDAT- 2011/04/14 06:00
MHDA- 2011/06/24 06:00
CRDT- 2011/04/14 06:00
PHST- 2011/04/14 06:00 [entrez]
PHST- 2011/04/14 06:00 [pubmed]
PHST- 2011/06/24 06:00 [medline]
PST - ppublish
SO  - Neuropsychiatr. 2011;25(1):44-50.


PMID- 21486538
OWN - NLM
STAT- MEDLINE
DCOM- 20110623
LR  - 20110413
IS  - 0948-6259 (Print)
IS  - 0948-6259 (Linking)
VI  - 25
IP  - 1
DP  - 2011
TI  - [Deep brain stimulation: a review on current research].
PG  - 1-8
AB  - Recently Deep brain stimulation (DBS) has found continuous use in treatment of
      neurological movement disorders. However DBS in psychiatric illnesses is less
      investigated. Its application in depression, obsessive-compulsive disorder, and
      therapy-resistant Tourette- Syndrome shows positive effects and offers an
      advanced alternative to neurosurgical therapies of the past. There are also case 
      reports suggesting therapeutic benefits in schizophrenia and addiction. To a
      large extent, the mechanisms of action appear to be still unknown; the side
      effects seem partially modulated through the stimulation parameters. Furthermore,
      some ethics committees argue that DBS exhibits a relevant impact on the
      personality. The novel approach as well as the unknown long term effects of DBS
      implicate that the technique can be performed only under strict individual
      diagnosis and rigorous consideration of all ethical concerns.
FAU - Conca, Andreas
AU  - Conca A
AD  - Psychiatrischer Dienst des Gesundheitsbezirkes Bozen-Suditrol.
FAU - Di Pauli, Jan
AU  - Di Pauli J
FAU - Hinterhuber, Hartmann
AU  - Hinterhuber H
FAU - Kapfhammer, Hans-Peter
AU  - Kapfhammer HP
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Die tiefe Hirnstimulation: Zum Stand der aktuellen Forschung - eine Ubersicht.
PL  - Germany
TA  - Neuropsychiatr
JT  - Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der
      Gesellschaft Osterreichischer Nervenarzte und Psychiater
JID - 9440588
SB  - IM
MH  - Austria
MH  - Brain/physiopathology
MH  - Brain Mapping
MH  - Central Nervous System Diseases/physiopathology/*therapy
MH  - Deep Brain Stimulation/ethics/*methods
MH  - Electrodes, Implanted
MH  - Ethics, Medical
MH  - Humans
MH  - Mental Disorders/physiopathology/*therapy
MH  - Risk Assessment/ethics
MH  - Synaptic Transmission/physiology
EDAT- 2011/04/14 06:00
MHDA- 2011/06/24 06:00
CRDT- 2011/04/14 06:00
PHST- 2011/04/14 06:00 [entrez]
PHST- 2011/04/14 06:00 [pubmed]
PHST- 2011/06/24 06:00 [medline]
PST - ppublish
SO  - Neuropsychiatr. 2011;25(1):1-8.


PMID- 21486292
OWN - NLM
STAT- MEDLINE
DCOM- 20110621
LR  - 20170612
IS  - 1749-6632 (Electronic)
IS  - 0077-8923 (Linking)
VI  - 1224
DP  - 2011 Apr
TI  - Interview with Michael Gazzaniga.
PG  - 1-8
LID - 10.1111/j.1749-6632.2011.05998.x [doi]
AB  - Widely considered the father of the field of cognitive neuroscience, Professor
      Michael S. Gazzaniga is one of the world's premier neuroscientists. He founded
      the Center for Neuroscience at the University of California, Davis; the Center
      for Cognitive Neuroscience at Dartmouth College; the Cognitive Neuroscience
      Institute; Journal of Cognitive Neuroscience; and the Cognitive Neuroscience
      Society. He is currently the director of the Sage Center for the Study of the
      Mind at the University of California, Santa Barbara. Born on December 12, 1939 in
      Los Angeles and educated at Dartmouth College, he received his Ph.D. in
      psychobiology at the California Institute of Technology under the tutelage of
      Roger Sperry. As a graduate student, Professor Gazzaniga initiated the first
      lateralized testing of human split-brain patients, leading to a fundamental shift
      in our understanding of functional lateralization in the brain and how the
      cerebral hemispheres communicate with one another. His many scholarly
      publications and pioneering work during the last 50 years have produced
      significant contributions to our understanding of how the brain enables the mind.
      His landmark 1995 book for MIT Press, The Cognitive Neurosciences, now in its
      fourth edition, is recognized as the sourcebook for the field. He has also
      published many books accessible to a lay audience, including Mind Matters,
      Nature's Mind, and The Ethical Brain.
LA  - eng
PT  - Historical Article
PT  - Interview
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
SB  - IM
MH  - Cognition/physiology
MH  - Culture
MH  - Education, Medical
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Neurobiology/education/history/methods/*trends
MH  - Neuropsychological Tests/history
MH  - Neuropsychology/history/methods/*trends
MH  - Neurosciences/education/history/methods/trends
MH  - Publishing/trends
MH  - Punishment/psychology
MH  - Reward
EDAT- 2011/04/14 06:00
MHDA- 2011/06/22 06:00
CRDT- 2011/04/14 06:00
PHST- 2011/04/14 06:00 [entrez]
PHST- 2011/04/14 06:00 [pubmed]
PHST- 2011/06/22 06:00 [medline]
AID - 10.1111/j.1749-6632.2011.05998.x [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2011 Apr;1224:1-8. doi: 10.1111/j.1749-6632.2011.05998.x.


PMID- 21485979
OWN - NLM
STAT- MEDLINE
DCOM- 20110708
LR  - 20220316
IS  - 0279-3695 (Print)
IS  - 0279-3695 (Linking)
VI  - 49
IP  - 5
DP  - 2011 May
TI  - Integrating a professional apprenticeship model with psychiatric clinical
      simulation.
PG  - 42-9
LID - 10.3928/02793695-20110329-01 [doi]
AB  - In this article, we present a theory-based application of clinical simulation in 
      psychiatric-mental health nursing education. As described by Benner, Sutphen,
      Leonard, and Day, a three-pronged apprenticeship that integrates intellectual,
      practical, and ethical aspects of the professional role is critical in the
      development of practical reasoning in nursing education and training. Clinical
      encounters are often fraught with ambiguity and uncertainty. Therefore, educating
      for a practice discipline requires experiential and situated learning. Using the 
      three-pronged experiential model in simulated psychiatric-mental health nursing
      practice supports the development of critical nursing skills, ethics, and
      theoretical concepts. A clinical scenario is presented that demonstrates the
      application of this model of professional apprenticeship in psychiatric-mental
      health education. Applications of the concept presented may be used in training
      nurses new to the practice of psychiatric-mental health nursing.
CI  - Copyright 2011, SLACK Incorporated.
FAU - Crider, Mark C
AU  - Crider MC
AD  - The Valley Foundation School of Nursing, San Jose State University, San Jose,
      California 95192-0057, USA. Mark.Crider@sjsu.edu
FAU - McNiesh, Susan G
AU  - McNiesh SG
LA  - eng
PT  - Journal Article
DEP - 20110413
PL  - United States
TA  - J Psychosoc Nurs Ment Health Serv
JT  - Journal of psychosocial nursing and mental health services
JID - 8200911
SB  - IM
MH  - Adult
MH  - Curriculum
MH  - Female
MH  - Humans
MH  - Mental Disorders/*nursing
MH  - *Models, Educational
MH  - Nurse's Role/psychology
MH  - Nurse-Patient Relations
MH  - Nursing Assessment
MH  - Patient Admission
MH  - *Patient Simulation
MH  - Preceptorship/*methods
MH  - Psychiatric Department, Hospital
MH  - Psychiatric Nursing/*education
MH  - Schizophrenia, Paranoid/nursing
EDAT- 2011/04/14 06:00
MHDA- 2011/07/09 06:00
CRDT- 2011/04/14 06:00
PHST- 2010/12/08 00:00 [received]
PHST- 2011/02/14 00:00 [accepted]
PHST- 2011/04/14 06:00 [entrez]
PHST- 2011/04/14 06:00 [pubmed]
PHST- 2011/07/09 06:00 [medline]
AID - 10.3928/02793695-20110329-01 [doi]
PST - ppublish
SO  - J Psychosoc Nurs Ment Health Serv. 2011 May;49(5):42-9. doi:
      10.3928/02793695-20110329-01. Epub 2011 Apr 13.


PMID- 21485948
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20191112
IS  - 1526-9248 (Print)
IS  - 1526-9248 (Linking)
VI  - 21
IP  - 1
DP  - 2011 Mar
TI  - Ethics at the end of life in transplant recipients.
PG  - 83-7
AB  - The field of transplantation is intended to try to save or improve people's
      lives. In some situations though, the length of a person's life is not as vital
      as the quality of that life. As a member of a transplant team, one must recognize
      the differences between quality and quantity and apply the ethical principles of 
      autonomy, justice, nonmaleficence, and beneficence. When a lung transplant
      recipient became ill with posttransplant lymphoproliferative disease 10 months
      after her surgery, these ethical principles came to the foreground. This dynamic,
      vibrant woman, recently engaged, faced her own mortality with grace. There is a
      time for everything. When death is a long time coming, many people are referred
      to hospice care and the death is viewed as a blessing. This situation rarely
      occurs in the transplant field. Many people, whether professionals or laypersons,
      have a difficult time letting go. Our team and this very special woman all knew
      when it was time. Creating a warm and open environment in the intensive care unit
      helped her through the rhythms of transition in dying.
FAU - Stecher, Jo
AU  - Stecher J
AD  - Florida Gulf Coast University, Fort Myers, Florida 33965, USA. jstecher@fgcu.edu
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Prog Transplant
JT  - Progress in transplantation (Aliso Viejo, Calif.)
JID - 100909380
MH  - Adult
MH  - Female
MH  - Humans
MH  - Living Wills
MH  - Lung Transplantation/*ethics
MH  - Patient Care Team
MH  - Quality of Life
MH  - Terminal Care/*ethics
EDAT- 2011/04/14 06:00
MHDA- 2011/06/29 06:00
CRDT- 2011/04/14 06:00
PHST- 2011/04/14 06:00 [entrez]
PHST- 2011/04/14 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
AID - 10.7182/prtr.21.1.n1w1108r172r2372 [doi]
PST - ppublish
SO  - Prog Transplant. 2011 Mar;21(1):83-7. doi: 10.7182/prtr.21.1.n1w1108r172r2372.


PMID- 21485790
OWN - NLM
STAT- MEDLINE
DCOM- 20110601
LR  - 20190923
IS  - 1550-7033 (Print)
IS  - 1550-7033 (Linking)
VI  - 7
IP  - 1
DP  - 2011 Feb
TI  - Policy and ethical concerns in nanotechnology safety: case of Indian health
      sector.
PG  - 34-5
AB  - The governance of nanotechnology in the health sector in India poses certain
      challenges on the front of capability and innovation, risks and regulation.
      Devising and adhering to the voluntary standards at a stage of regulatory
      uncertainty, collation and provision of knowledge on impacts, occupational
      hazards, waste disposal etc. for further risk research and policy design are the 
      issues industry can address in shaping the nanotechnology governance framework.
FAU - Anand, Manish
AU  - Anand M
AD  - The Energy and Resources Institute (TERI), IHC Complex, Lodhi Road, New Delhi
      110003, India.
FAU - Srivastava, Nidhi
AU  - Srivastava N
FAU - Sarma, Shilpanjali
AU  - Sarma S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Biomed Nanotechnol
JT  - Journal of biomedical nanotechnology
JID - 101230869
SB  - IM
MH  - *Consumer Product Safety
MH  - Delivery of Health Care/*ethics
MH  - Drug-Related Side Effects and Adverse Reactions/*prevention & control
MH  - Health Care Sector/*ethics
MH  - *Health Policy
MH  - Humans
MH  - India
MH  - Nanomedicine/*ethics
EDAT- 2011/04/14 06:00
MHDA- 2011/06/02 06:00
CRDT- 2011/04/14 06:00
PHST- 2011/04/14 06:00 [entrez]
PHST- 2011/04/14 06:00 [pubmed]
PHST- 2011/06/02 06:00 [medline]
AID - 10.1166/jbn.2011.1188 [doi]
PST - ppublish
SO  - J Biomed Nanotechnol. 2011 Feb;7(1):34-5. doi: 10.1166/jbn.2011.1188.


PMID- 21485617
OWN - NLM
STAT- MEDLINE
DCOM- 20110525
LR  - 20110413
IS  - 0097-9805 (Print)
IS  - 0097-9805 (Linking)
VI  - 37
IP  - 1
DP  - 2011 Jan-Feb
TI  - Brain death, the pediatric patient, and the nurse.
PG  - 17-21, 38; quiz 22
AB  - The term "brain death" has ties to medical, legal, ethical, and philosophical
      discourse, and is therefore a complicated and potentially ambiguous term. Some
      state that with brain death a person no longer has a "master regulating" organ
      integrating his or her organism as a whole, and the proponents of this view
      equate this loss of integration with clinical death. Others believe this is not a
      tenable reason to deem an individual who is brain dead as clinically dead; thus, 
      controversy exists surrounding this issue, and nurses are not resistant to this
      debate. Whether one supports the definition of brain death as clinical death or
      not appears to depend on one's view of the mind-body relationship. Pediatric
      nurses are involved in this controversy because of the care they provide to both 
      the affected child and family in this troubling time.
FAU - Zielinski, Pamela B
AU  - Zielinski PB
AD  - University of Alberta, Edmonton, Alberta, Canada.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pediatr Nurs
JT  - Pediatric nursing
JID - 7505804
MH  - *Brain Death/diagnosis/legislation & jurisprudence
MH  - Child
MH  - Education, Nursing, Continuing
MH  - Humans
MH  - *Nurses
EDAT- 2011/04/14 06:00
MHDA- 2011/05/26 06:00
CRDT- 2011/04/14 06:00
PHST- 2011/04/14 06:00 [entrez]
PHST- 2011/04/14 06:00 [pubmed]
PHST- 2011/05/26 06:00 [medline]
PST - ppublish
SO  - Pediatr Nurs. 2011 Jan-Feb;37(1):17-21, 38; quiz 22.


PMID- 21485215
OWN - NLM
STAT- MEDLINE
DCOM- 20120223
LR  - 20110411
IS  - 1001-5515 (Print)
IS  - 1001-5515 (Linking)
VI  - 28
IP  - 1
DP  - 2011 Feb
TI  - [Generation and application of pluripotent stem cells from spermatogonial stem
      cells].
PG  - 208-12
AB  - Recent studies have confirmed that diverse adult tissue cells can be reprogrammed
      and induced to pluripotency, that is so-called induced pluripotent stem cells
      (iPS cells). But most of these dedifferentiated processes are induced by gene
      delivery with retroviral vectors. Some of the delivered genes are cancer causing.
      So, in current situation, these adult-derived embryonic stem-like cells cannot be
      used in clinical therapy to cure human diseases. Recently some articles that were
      published in the authoritative journals are receiving attentions. They show that,
      in mice and human, spermatogonial stem cells (SSCs) can be used for generating
      pluripotent stem cells without the exogenous genes and retroviruses, and they can
      also be used for autologous transplantation without ethical problems. These
      findings suggest that human SSCs may have considerable potential for cell-based, 
      autologous organ regeneration therapy for various diseases. In this review, we
      describe and compare the methods that have been used to isolate, purificate and
      culture SSCs. We also describe the recent results in which SSCs can be
      transformed into pluripotent stem cells, and the pluripotent stem cells have
      potential applications in regenerative medicine and genetic medicine.
FAU - Zhang, Yan
AU  - Zhang Y
AD  - Key Laboratory of China Education Ministry for the Research of Mammal
      Reproductive Biology and Biotechnology, Inner Mongolia University, Hohhot 010021,
      China.
FAU - Wu, Yingji
AU  - Wu Y
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - China
TA  - Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
JT  - Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering =
      Shengwu yixue gongchengxue zazhi
JID - 9426398
SB  - IM
MH  - Cell Culture Techniques/*methods
MH  - Cell Dedifferentiation/*physiology
MH  - Cells, Cultured
MH  - Humans
MH  - Male
MH  - Pluripotent Stem Cells/*cytology
MH  - Spermatogonia/*cytology
MH  - Stem Cells/*cytology
EDAT- 2011/04/13 06:00
MHDA- 2012/02/24 06:00
CRDT- 2011/04/13 06:00
PHST- 2011/04/13 06:00 [entrez]
PHST- 2011/04/13 06:00 [pubmed]
PHST- 2012/02/24 06:00 [medline]
PST - ppublish
SO  - Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2011 Feb;28(1):208-12.


PMID- 21485041
OWN - NLM
STAT- MEDLINE
DCOM- 20110517
LR  - 20161020
IS  - 0723-2276 (Print)
IS  - 0723-2276 (Linking)
VI  - 30
IP  - 3
DP  - 2011 Mar
TI  - [Ethical principles in the health care career. "Nursing with heart"].
PG  - 96
FAU - Foellbach, Heidemarie
AU  - Foellbach H
AD  - heidifoellbach@gmail.com
LA  - ger
PT  - Journal Article
TT  - Ethische Grundsatze im Gesundheitsberuf. "Mit dem Herzen pflegen".
PL  - Germany
TA  - Kinderkrankenschwester
JT  - Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege
JID - 8305989
MH  - Child
MH  - *Emotional Intelligence
MH  - *Empathy
MH  - *Ethics, Nursing
MH  - Humans
MH  - Nurse-Patient Relations/*ethics
EDAT- 2011/04/13 06:00
MHDA- 2011/05/18 06:00
CRDT- 2011/04/13 06:00
PHST- 2011/04/13 06:00 [entrez]
PHST- 2011/04/13 06:00 [pubmed]
PHST- 2011/05/18 06:00 [medline]
PST - ppublish
SO  - Kinderkrankenschwester. 2011 Mar;30(3):96.


PMID- 21484841
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20191210
IS  - 1097-0223 (Electronic)
IS  - 0197-3851 (Linking)
VI  - 31
IP  - 6
DP  - 2011 Jun
TI  - When referring physicians and researchers disagree on equipoise: the TOTAL trial 
      experience.
PG  - 589-94
LID - 10.1002/pd.2756 [doi]
AB  - OBJECTIVE: In this article, we reflect on whether randomized controlled trials
      (RCTs) are adequate for the clinical evaluation of maternal-fetal surgery for
      congenital diaphragmatic hernia (CDH), focusing on the role of patients'
      preferences in the setting up of research protocols, on the requirement of
      equipoise and on the concept of therapeutic misconception (TM). METHOD: We
      describe the conception and setting up of the tracheal occlusion (TO) to
      accelerate lung growth trial and analyze the ethical dilemmas faced by the
      research team during that time. RESULTS: Depending on the view adopted regarding 
      the scope of equipoise, there are two ways of dealing with patient's preferences 
      concerning fetoscopic endoluminal TO and expectant management during pregnancy
      for CDH. CONCLUSION: The solution adopted for fetoscopic endoluminal tracheal
      occlusion (FETO) is justified by the extended period of time it has been
      available to patients before the start of the RCT. Strong patient and referring
      physician preferences do not entail a right to have FETO, since it is a procedure
      of yet unproven efficacy and safety. In the future, to avoid the dilemmas posed
      by the TM and in name of the right of future generations of patients to have
      access to treatment of proven safety and efficacy, researchers must be able to
      plan RCT in due time.
CI  - Copyright (c) 2011 John Wiley & Sons, Ltd.
FAU - Rodrigues, H C M L
AU  - Rodrigues HC
AD  - Department of Obstetrics and Gynecology, University Medical Centre Groningen,
      Groningen, The Netherlands. h.c.m.l.rodriques@og.umcg.nl
FAU - Deprest, J
AU  - Deprest J
FAU - v d Berg, P P
AU  - v d Berg PP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110411
PL  - England
TA  - Prenat Diagn
JT  - Prenatal diagnosis
JID - 8106540
SB  - IM
MH  - Conflict, Psychological
MH  - *Dissent and Disputes
MH  - Female
MH  - Fetoscopy/ethics/statistics & numerical data
MH  - *Hernia, Diaphragmatic/surgery
MH  - Hernias, Diaphragmatic, Congenital
MH  - Humans
MH  - Patient Preference
MH  - Patient Selection/ethics
MH  - *Physicians, Primary Care/ethics
MH  - Pregnancy
MH  - Randomized Controlled Trials as Topic/ethics/methods/standards
MH  - *Referral and Consultation/statistics & numerical data
MH  - Research Design
MH  - *Research Personnel/ethics
MH  - Retrospective Studies
MH  - *Therapeutic Equipoise
EDAT- 2011/04/13 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/04/13 06:00
PHST- 2011/02/02 00:00 [received]
PHST- 2011/03/03 00:00 [revised]
PHST- 2011/03/03 00:00 [accepted]
PHST- 2011/04/13 06:00 [entrez]
PHST- 2011/04/13 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - 10.1002/pd.2756 [doi]
PST - ppublish
SO  - Prenat Diagn. 2011 Jun;31(6):589-94. doi: 10.1002/pd.2756. Epub 2011 Apr 11.


PMID- 21484320
OWN - NLM
STAT- MEDLINE
DCOM- 20131122
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 18
IP  - 4
DP  - 2012 Dec
TI  - The conception of life in synthetic biology.
PG  - 757-74
LID - 10.1007/s11948-011-9269-z [doi]
AB  - The phrase 'synthetic biology' is used to describe a set of different scientific 
      and technological disciplines, which share the objective to design and produce
      new life forms. This essay addresses the following questions: What conception of 
      life stands behind this ambitious objective? In what relation does this
      conception of life stand to that of traditional biology and biotechnology? And,
      could such a conception of life raise ethical concerns? Three different
      observations that provide useful indications for the conception of life in
      synthetic biology will be discussed in detail: 1. Synthetic biologists focus on
      different features of living organisms in order to design new life forms, 2.
      Synthetic biologists want to contribute to the understanding of life, and 3.
      Synthetic biologists want to modify life through a rational design, which implies
      the notions of utilising, minimising/optimising, varying and overcoming life.
      These observations indicate a tight connection between science and technology, a 
      focus on selected aspects of life, a production-oriented approach to life, and a 
      design-oriented understanding of life. It will be argued that through this
      conception of life synthetic biologists present life in a different light. This
      conception of life will be illustrated by the metaphor of a toolbox. According to
      the notion of life as a toolbox, the different features of living organisms are
      perceived as various rationally designed instruments that can be used for the
      production of the living organism itself or secondary products made by the
      organism. According to certain ethical positions this conception of life might
      raise ethical concerns related to the status of the organism, the motives of the 
      scientists and the role of technology in our society.
FAU - Deplazes-Zemp, Anna
AU  - Deplazes-Zemp A
AD  - University of Zurich, IBME, Pestalozzistr. 24, 8032, Zurich, Switzerland.
      deplazes@ethik.uzh.ch
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110412
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Biotechnology/*ethics
MH  - *Comprehension
MH  - *Concept Formation
MH  - *Life
MH  - Metaphor
MH  - Synthetic Biology/*ethics
EDAT- 2011/04/13 06:00
MHDA- 2013/12/16 06:00
CRDT- 2011/04/13 06:00
PHST- 2010/11/23 00:00 [received]
PHST- 2011/03/28 00:00 [accepted]
PHST- 2011/04/13 06:00 [entrez]
PHST- 2011/04/13 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1007/s11948-011-9269-z [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2012 Dec;18(4):757-74. doi: 10.1007/s11948-011-9269-z. Epub 2011 
      Apr 12.


PMID- 21484234
OWN - NLM
STAT- MEDLINE
DCOM- 20120906
LR  - 20211020
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Linking)
VI  - 28
IP  - 3
DP  - 2012 Mar
TI  - A minimally-invasive closed chest myocardial occlusion-reperfusion model in
      rhesus monkeys (Macaca mulatta): monitoring by contrast-enhanced ultrasound
      imaging.
PG  - 531-42
LID - 10.1007/s10554-011-9859-5 [doi]
AB  - Myocardial infarction is frequently developed in canine and porcine models but
      exceptionally in non-human primates. The aim of this study was to develop a
      minimally invasive myocardial ischemic/reperfusion model in the monkey intended
      to be combined with imaging techniques, in particular myocardial contrast
      echocardiography (MCE). A balloon-tipped catheter was advanced via the femoral
      artery into the left anterior descending artery (LAD) under fluoroscopic guidance
      in ten anaesthetized male rhesus monkeys (Macaca mulatta). The balloon was
      inflated to completely occlude the vessel. Coronary angiography (CA) was
      performed to control the reality of the LAD occlusion/reperfusion. The ischemia
      period was followed by 3-6 h of reperfusion. Myocardial perfusion was evaluated
      during ischemia and at reperfusion by MCE using a novel ultrasound contrast agent
      (BR38). Occlusion was successfully induced during 18-50 min in nine out of the
      ten evaluated monkeys. ST segment elevation indicated myocardial ischemia. MCE
      showed complete transmural arrest of myocardial blood flow during the ischemia
      period and no persistent microvascular perfusion defects during reperfusion. A
      minimally invasive closed-chest model was successfully developed for creating
      myocardial ischemia in the rhesus monkey (Macaca mulatta). This technique could
      have an important role in mimicking acute coronary syndrome under physiologically
      and ethically-acceptable conditions. MCE provides non-invasively information on
      myocardial perfusion status, information not available from CA.
FAU - Contamin, Hugues
AU  - Contamin H
AD  - Cynbiose, 1 avenue Bourgelat, 69280 Marcy l'Etoile, France.
      hugues.contamin@cynbiose.com
FAU - Rioufol, Gilles
AU  - Rioufol G
FAU - Bettinger, Thierry
AU  - Bettinger T
FAU - Helbert, Alexandre
AU  - Helbert A
FAU - Portier, Karine G
AU  - Portier KG
FAU - Lepage, Olivier M
AU  - Lepage OM
FAU - Thomas, Regi
AU  - Thomas R
FAU - Broillet, Anne
AU  - Broillet A
FAU - Tranquart, Francois
AU  - Tranquart F
FAU - Schneider, Michel
AU  - Schneider M
LA  - eng
PT  - Journal Article
DEP - 20110412
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
RN  - 0 (Contrast Media)
SB  - IM
MH  - Animals
MH  - Balloon Occlusion
MH  - Collateral Circulation
MH  - *Contrast Media
MH  - Coronary Angiography
MH  - *Coronary Circulation
MH  - Disease Models, Animal
MH  - Echocardiography/*methods
MH  - Macaca mulatta
MH  - Male
MH  - Microbubbles
MH  - Myocardial Infarction/*diagnostic imaging/etiology/pathology/physiopathology
MH  - Myocardial Ischemia/*diagnostic imaging/etiology/pathology/physiopathology
MH  - Myocardial Reperfusion Injury/*diagnostic
      imaging/etiology/pathology/physiopathology
MH  - Myocardium/pathology
MH  - Stroke Volume
MH  - Time Factors
MH  - Ventricular Function, Left
EDAT- 2011/04/13 06:00
MHDA- 2012/09/07 06:00
CRDT- 2011/04/13 06:00
PHST- 2010/10/14 00:00 [received]
PHST- 2011/03/29 00:00 [accepted]
PHST- 2011/04/13 06:00 [entrez]
PHST- 2011/04/13 06:00 [pubmed]
PHST- 2012/09/07 06:00 [medline]
AID - 10.1007/s10554-011-9859-5 [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2012 Mar;28(3):531-42. doi: 10.1007/s10554-011-9859-5. 
      Epub 2011 Apr 12.


PMID- 21484199
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20220129
IS  - 1866-1955 (Electronic)
IS  - 1866-1947 (Linking)
VI  - 3
IP  - 2
DP  - 2011 Jun
TI  - A family with autism and rare copy number variants disrupting the Duchenne/Becker
      muscular dystrophy gene DMD and TRPM3.
PG  - 124-31
LID - 10.1007/s11689-011-9076-5 [doi]
AB  - Autism spectrum disorder is a genetically complex and clinically heterogeneous
      neurodevelopmental disorder. A recent study by the Autism Genome Project (AGP)
      used 1M single-nucleotide polymorphism arrays to show that rare genic copy number
      variants (CNVs), possibly acting in tandem, play a significant role in the
      genetic aetiology of this condition. In this study, we describe the phenotypic
      and genomic characterisation of a multiplex autism family from the AGP study that
      was found to harbour a duplication of exons 31-44 of the Duchenne/Becker muscular
      dystrophy gene DMD and also a rare deletion involving exons 1-9 of TRPM3. Further
      characterisation of these extremely rare CNVs was carried out using quantitative 
      PCR, fluorescent in situ hybridisation, long-range PCR amplification and
      sequencing of junction fragments. The maternal chrX:32,097,213-32,321,945 tandem 
      duplication and paternal chr9:72,480,413-73,064,196 deletion (NCBI build 36
      coordinates) were transmitted to both affected boys, potentially signifying a
      multi-hit mechanism. The DMD reading frame rule predicts a Becker phenotype,
      characterised by later onset and milder symptoms. When last evaluated, neither
      child had developed signs of muscular dystrophy. These data are consistent with a
      degree of comorbidity between autism and muscular dystrophy and suggest that
      genomic background as well as the position of the mutation within the DMD gene
      may impact on the neurological correlates of Duchenne/Becker muscular dystrophy. 
      Finally, communicating unexpected findings such as these back to families raises 
      a number of ethical questions, which are discussed.
FAU - Pagnamenta, Alistair T
AU  - Pagnamenta AT
AD  - Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, 
      Headington, Oxford, OX3 7BN, UK.
FAU - Holt, Richard
AU  - Holt R
FAU - Yusuf, Mohammed
AU  - Yusuf M
FAU - Pinto, Dalila
AU  - Pinto D
FAU - Wing, Kirsty
AU  - Wing K
FAU - Betancur, Catalina
AU  - Betancur C
FAU - Scherer, Stephen W
AU  - Scherer SW
FAU - Volpi, Emanuela V
AU  - Volpi EV
FAU - Monaco, Anthony P
AU  - Monaco AP
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - 090532/WT_/Wellcome Trust/United Kingdom
GR  - G0601030/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
DEP - 20110212
PL  - England
TA  - J Neurodev Disord
JT  - Journal of neurodevelopmental disorders
JID - 101483832
PMC - PMC3105230
MID - HALMS598894
OID - NLM: HALMS598894
EDAT- 2011/04/13 06:00
MHDA- 2011/04/13 06:01
CRDT- 2011/04/13 06:00
PHST- 2010/11/17 00:00 [received]
PHST- 2011/01/27 00:00 [accepted]
PHST- 2011/04/13 06:00 [entrez]
PHST- 2011/04/13 06:00 [pubmed]
PHST- 2011/04/13 06:01 [medline]
AID - 10.1007/s11689-011-9076-5 [doi]
PST - ppublish
SO  - J Neurodev Disord. 2011 Jun;3(2):124-31. doi: 10.1007/s11689-011-9076-5. Epub
      2011 Feb 12.


PMID- 21484074
OWN - NLM
STAT- MEDLINE
DCOM- 20110901
LR  - 20191027
IS  - 2013-6463 (Electronic)
IS  - 1575-0620 (Linking)
VI  - 13
IP  - 1
DP  - 2011
TI  - [Concordance of tuberculin tests and Interferon gamma release assays in the
      prison population].
PG  - 15-20
LID - S1575-06202011000100003 [pii]
AB  - OBJECTIVE: To study the agreement of Tuberculin Skin Tests (TST) and Interferon
      Gamma Release Assays (IGRA) when screening tuberculosis infection amongst inmates
      recently admitted to prison. MATERIALS AND METHODS: Prospective study conducted
      in a prison during the months of May and June 2009. Inmates without a TB history,
      with previous TST negatives or without prior TSTs were included. Participants
      signed an informed consent form and the study was approved by an independent
      Ethical Committee. TST (positive 10 > or = mm) and IGRA (Quantiferon TB-Gold)
      were performed and standardized data collection was carried out. The agreement
      between both tests was analysed using the Kappa index. RESULTS: A total of 181
      people were included. 62% were foreign-born, 17% had previous BCG vaccination,
      8.4% were IDUs and 4% HIV-infected. Foreign born subjects were more frequently
      vaccinated and presented less drug use and HIV infection than people born in
      Spain. (p=0.02, p=0.02 and p=0.01 respectively). TST results were positive in 24%
      and IGRA in 26%. Both tests were performed in 149 people (82%). Discordant
      results were observed in 15.8%. Agreement of the Kappa coefficient was 0.6 (CI
      0.4-0.7). Agreement was better in the native population (K=0.8) and worse in BCG 
      vaccinated (K=0.4) and foreign-born subjects (K=0.8). CONCLUSION: Overall
      agreement was moderate and was less amongst vaccinated subjects and those born
      abroad. Extension of the study could be useful to evaluate which test better
      predicts the risk of progression to active TB and the cost-benefit of both tests 
      among the prison population.
FAU - Marco Mourino, A
AU  - Marco Mourino A
AD  - Servicios Medicos, Centro Penitenciario de Hombres de Barcelona, Barcelona,
      Espana. andres.marco.m@gmail.com
FAU - Orcau Palau, A
AU  - Orcau Palau A
FAU - Jane Galliga, R
AU  - Jane Galliga R
FAU - Escribano Ibanez, M
AU  - Escribano Ibanez M
FAU - Cayla Buqueras, J A
AU  - Cayla Buqueras JA
FAU - Sole Zapata, N
AU  - Sole Zapata N
FAU - del Bano Hollin, L
AU  - del Bano Hollin L
FAU - Quintero del Rio, S
AU  - Quintero del Rio S
FAU - Ferrer Escobar, M D
AU  - Ferrer Escobar MD
FAU - Mangues Bafalluy, J
AU  - Mangues Bafalluy J
FAU - Guerrero Moreno, R A
AU  - Guerrero Moreno RA
FAU - Martin Sanchez, V
AU  - Martin Sanchez V
LA  - spa
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
TT  - Concordancia de las pruebas de tuberculina e Interferon gamma en poblacion
      reclusa.
PL  - Spain
TA  - Rev Esp Sanid Penit
JT  - Revista espanola de sanidad penitenciaria
JID - 101284897
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Humans
MH  - Interferon-gamma/*blood
MH  - Male
MH  - Middle Aged
MH  - *Prisoners
MH  - Prospective Studies
MH  - *Tuberculin Test
MH  - Tuberculosis/*blood/*diagnosis
MH  - Young Adult
EDAT- 2011/04/13 06:00
MHDA- 2011/09/02 06:00
CRDT- 2011/04/13 06:00
PHST- 2010/10/18 00:00 [received]
PHST- 2011/02/05 00:00 [accepted]
PHST- 2011/04/13 06:00 [entrez]
PHST- 2011/04/13 06:00 [pubmed]
PHST- 2011/09/02 06:00 [medline]
AID - S1575-06202011000100003 [pii]
AID - 10.4321/s1575-06202011000100003 [doi]
PST - ppublish
SO  - Rev Esp Sanid Penit. 2011;13(1):15-20. doi: 10.4321/s1575-06202011000100003.


PMID- 21483402
OWN - NLM
STAT- MEDLINE
DCOM- 20110902
LR  - 20110412
IS  - 0026-4806 (Print)
IS  - 0026-4806 (Linking)
VI  - 102
IP  - 2
DP  - 2011 Apr
TI  - Guidelines for genetic counselling for neurological diseases: ethical issues.
PG  - 149-59
AB  - Genetic testing are available for a long list of neurodegenerative diseases. The 
      most authoritative scientific and health-care institutions agree that dementia is
      going to be one of the major problems and most challenging priorities for public 
      health care in upcoming years. Genetic counselling is a complex field.
      Technically speaking, the term "guideline" has a very specific meaning. Several
      guidelines for genetic testing for neurology diseases are available. The article 
      summarizes, from an ethical perspective, the main guidelines for genetic
      counselling in the neurological filed and suggests four main conclusions: 1)
      guidelines contain a superabundance of indications for genetic counselling for
      persons who are potentially at risk of developing neurological disorders, but
      perhaps are lacking with regard to the question of genetic counselling for
      persons already affected by mental disorders; 2) there is a risk that genetic
      testing abuses for disorders of neurological complexity will lead to confusion;
      3) there is a risk that confusion will derive not only from the overuse of
      genetic testing, but also from the proliferation of guidelines; 4) codes and
      guidelines do not eliminate the need for ethical awareness in interpreting them.
FAU - Petrini, C
AU  - Petrini C
AD  - Bioethics Unit, National Institute of Health, Rome, Italy. carlo.petrini@iss.it
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - Minerva Med
JT  - Minerva medica
JID - 0400732
SB  - IM
MH  - Bioethical Issues/*standards
MH  - Dementia/genetics
MH  - Ethical Theory
MH  - Genetic Counseling/*ethics
MH  - Humans
MH  - Nervous System Diseases/*genetics
MH  - *Practice Guidelines as Topic
EDAT- 2011/04/13 06:00
MHDA- 2011/09/03 06:00
CRDT- 2011/04/13 06:00
PHST- 2011/04/13 06:00 [entrez]
PHST- 2011/04/13 06:00 [pubmed]
PHST- 2011/09/03 06:00 [medline]
AID - R10113125 [pii]
PST - ppublish
SO  - Minerva Med. 2011 Apr;102(2):149-59.


PMID- 21482703
OWN - NLM
STAT- MEDLINE
DCOM- 20120320
LR  - 20211203
IS  - 1552-6127 (Electronic)
IS  - 1090-1981 (Linking)
VI  - 38
IP  - 6
DP  - 2011 Dec
TI  - To test or not to test? The role of attitudes, knowledge, and religious
      involvement among U.S. adults on intent-to-obtain adult genetic testing.
PG  - 617-28
LID - 10.1177/1090198110389711 [doi]
AB  - Genetic testing can advance cancer prevention if current screening behaviors
      improve. Increased prevalence of high-risk genotypes within specific religious
      groups, use of religious venues for recruiting to genetic screening, and
      ethical-religious considerations argue for exploring the role of religiosity in
      forming genetic testing decisions. This study uses the theory of reasoned action 
      and structural equation modeling to test the effects of religious involvement,
      attitudes, knowledge, and previous experience on intent-to-obtain genetic testing
      within a representative sample of 1,824 U.S. adults. A majority of respondents
      indicate willingness to test, especially for curable disorders. Attitudes,
      knowledge, and previous experience have significant direct effects, and religious
      involvement has an indirect effect, through its negative effect on attitudes, on 
      intent-to-test. High religious involvement is associated with more negative
      attitudes toward genetic testing. The findings underscore the need to refine
      genetic testing outreach efforts to account for multiple influences on consumer
      intent-to-test.
FAU - Botoseneanu, Anda
AU  - Botoseneanu A
AD  - University of Michigan, Ann Arbor, MI, USA. andabm@umich.edu
FAU - Alexander, Jeffrey A
AU  - Alexander JA
FAU - Banaszak-Holl, Jane
AU  - Banaszak-Holl J
LA  - eng
PT  - Journal Article
DEP - 20110411
PL  - United States
TA  - Health Educ Behav
JT  - Health education & behavior : the official publication of the Society for Public 
      Health Education
JID - 9704962
SB  - IM
MH  - Adult
MH  - African Americans
MH  - Catholicism/psychology
MH  - Factor Analysis, Statistical
MH  - Genetic Predisposition to Disease/ethnology/psychology
MH  - *Genetic Testing
MH  - Health Knowledge, Attitudes, Practice/*ethnology
MH  - Health Surveys
MH  - Humans
MH  - Intention
MH  - Jews/genetics/psychology
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/diagnosis/*genetics/prevention & control
MH  - *Religion and Medicine
MH  - United States
MH  - Whites
EDAT- 2011/04/13 06:00
MHDA- 2012/03/21 06:00
CRDT- 2011/04/13 06:00
PHST- 2011/04/13 06:00 [entrez]
PHST- 2011/04/13 06:00 [pubmed]
PHST- 2012/03/21 06:00 [medline]
AID - 1090198110389711 [pii]
AID - 10.1177/1090198110389711 [doi]
PST - ppublish
SO  - Health Educ Behav. 2011 Dec;38(6):617-28. doi: 10.1177/1090198110389711. Epub
      2011 Apr 11.


PMID- 21482129
OWN - NLM
STAT- MEDLINE
DCOM- 20120925
LR  - 20131121
IS  - 1878-4119 (Electronic)
IS  - 1010-5182 (Linking)
VI  - 40
IP  - 3
DP  - 2012 Apr
TI  - Resistance of the sheep skull after a monocortical cranial graft harvest.
PG  - 261-5
LID - 10.1016/j.jcms.2011.03.013 [doi]
AB  - INTRODUCTION: Cranial bone grafts are commonly used for preimplant or facial
      reconstructive surgery. However, removing bone may weaken the parietal bone and
      lead to a loss of strength. This loss has never been quantified. Bone harvest
      site reconstruction is being carried out more frequently than in the past, but
      its effect on the strength of the donor site is unknown. The aim of our study is 
      to quantify the loss of strength due to a monocortical cranial bone graft harvest
      in sheep. MATERIALS AND METHODS: Thirty-four fresh sheep cadaver heads were used 
      for the study. We performed a monocortical bone graft harvest on the posterior
      part of the right frontal bone. We used a surgical navigation system with
      optoelectronic tracking to measure bone thickness. To evaluate the resistance of 
      the skull to an impact we developed a pendulum Charpy impact testing machine. The
      impact force hit a defined target frontal area. RESULTS: The total thickness on
      both sides ranged from 3 mm to 10 mm with a mean of 6 mm (SD = 1.4 mm). The loss 
      of strength between the intact left side and the harvested right side varied with
      a mean of 49% (SD = 17%) and was significant (p = 6.10(-10)). CONCLUSION: This
      study has demonstrated that there is a loss of strength in the skull on the side 
      where a bone graft has been harvested. Reconstruction of the harvested site using
      biomaterials reduces the poor aesthetic outcome due to depression at the site,
      but we do not know its effects on strength. This kind of study cannot be
      performed in humans for ethical reasons. Data obtained from this study will allow
      us to carry out a study in sheep to evaluate strength of the frontal area of a
      skull with a harvest site reconstructed with hydroxyapatite cement.
CI  - Copyright (c) 2011 European Association for Cranio-Maxillo-Facial Surgery.
      Published by Elsevier Ltd. All rights reserved.
FAU - Laure, Boris
AU  - Laure B
AD  - Service de Chirurgie Maxillo-faciale et Plastique de la Face, Universite Francois
      Rabelais, Hopital Trousseau CHRU Tours, Tours Cedex, France.
FAU - Petraud, Anais
AU  - Petraud A
FAU - Sury, Florent
AU  - Sury F
FAU - Tranquart, Francois
AU  - Tranquart F
FAU - Goga, Dominique
AU  - Goga D
LA  - eng
PT  - Journal Article
DEP - 20110408
PL  - Scotland
TA  - J Craniomaxillofac Surg
JT  - Journal of cranio-maxillo-facial surgery : official publication of the European
      Association for Cranio-Maxillo-Facial Surgery
JID - 8704309
RN  - 0 (Bone Cements)
RN  - 0 (Hydroxyapatites)
RN  - 0 (hydroxyapatite cement)
SB  - IM
MH  - Animals
MH  - Biomechanical Phenomena
MH  - Bone Cements/therapeutic use
MH  - Cephalometry/methods
MH  - Frontal Bone/injuries/pathology/*surgery
MH  - Hydroxyapatites/therapeutic use
MH  - Models, Animal
MH  - Optical Devices
MH  - Reconstructive Surgical Procedures/methods
MH  - Sheep
MH  - Skull Fracture, Depressed/physiopathology
MH  - Stress, Mechanical
MH  - Surgery, Computer-Assisted
MH  - Tissue and Organ Harvesting/methods
MH  - Transplant Donor Site/pathology/*surgery
EDAT- 2011/04/13 06:00
MHDA- 2012/09/26 06:00
CRDT- 2011/04/13 06:00
PHST- 2010/09/17 00:00 [received]
PHST- 2011/01/06 00:00 [revised]
PHST- 2011/03/01 00:00 [accepted]
PHST- 2011/04/13 06:00 [entrez]
PHST- 2011/04/13 06:00 [pubmed]
PHST- 2012/09/26 06:00 [medline]
AID - S1010-5182(11)00056-4 [pii]
AID - 10.1016/j.jcms.2011.03.013 [doi]
PST - ppublish
SO  - J Craniomaxillofac Surg. 2012 Apr;40(3):261-5. doi: 10.1016/j.jcms.2011.03.013.
      Epub 2011 Apr 8.


PMID- 21481935
OWN - NLM
STAT- MEDLINE
DCOM- 20110816
LR  - 20111110
IS  - 1873-6386 (Electronic)
IS  - 0160-2527 (Linking)
VI  - 34
IP  - 2
DP  - 2011 Mar-Apr
TI  - Review on female sexual offenders: findings about profile and personality.
PG  - 122-6
LID - 10.1016/j.ijlp.2011.02.006 [doi]
AB  - INTRODUCTION: Although in the past sexual abuse was perceived as an issue
      connected only with males the contemporary literature is placing increasing
      emphasis on the role of female sexual perpetrators. There is still disagreement
      about the definition of sexual abuse, the frequency that it occurs and the
      characteristics of the women that are sexual abusers. METHODS: Thorough research 
      of the main databases (MEDLINE and PsycInfo), for case reviews and studies along 
      with restriction on European and North American literature, is due to perceived
      culture differences. Further investigation for relevant studies through web
      search engines such as Google, locates agencies and organizations that are
      interested and connected to sexual abuse issues. RESULTS: Distinction between
      sexual offense and sexual abuse has as a result difference in the characteristics
      of female sexual perpetrators. They are mainly young (age up to 36 years old),
      friends or relatives of the victim, using more persuasion and psychological
      coercion and legally charged in a lesser extent compared with male abusers.
      However the psychological consequences for the victim can be more severe.
      CONCLUSION: A unanimous view of what is female sexual abuse is difficult to
      reach. Often it is under reported, unrecognized or considered ethically more
      acceptable than male abuse. It is also connected with an increased self-report of
      history of sexual abuse of the perpetrators. A typology of female sexual abusers 
      should be developed. Treatments focusing on different psychological interventions
      along with prevention and public awareness can be a powerful tool in reduction of
      sexual abuse perpetrated by females.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Tsopelas, Christos
AU  - Tsopelas C
AD  - Psychiatric Hospital of Attica, Athens, Greece. tsopelas@gmail.com
FAU - Tsetsou, Spyridoula
AU  - Tsetsou S
FAU - Douzenis, Athanasios
AU  - Douzenis A
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110408
PL  - Netherlands
TA  - Int J Law Psychiatry
JT  - International journal of law and psychiatry
JID - 7806862
SB  - IM
EIN - Int J Law Psychiatry. 2011 Sep;34(5):379. Spyridoula, Tsetsou [corrected to
      Tsetsou, Spyridoula]; Athanasios, Douzenis [corrected to Douzenis, Athanasios]
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Child Abuse, Sexual/*psychology/statistics & numerical data
MH  - Family Conflict/psychology
MH  - Female
MH  - Humans
MH  - Male
MH  - Personality
MH  - Personality Disorders/psychology
MH  - Sex Factors
MH  - Young Adult
EDAT- 2011/04/13 06:00
MHDA- 2011/08/17 06:00
CRDT- 2011/04/13 06:00
PHST- 2011/04/13 06:00 [entrez]
PHST- 2011/04/13 06:00 [pubmed]
PHST- 2011/08/17 06:00 [medline]
AID - S0160-2527(11)00019-7 [pii]
AID - 10.1016/j.ijlp.2011.02.006 [doi]
PST - ppublish
SO  - Int J Law Psychiatry. 2011 Mar-Apr;34(2):122-6. doi: 10.1016/j.ijlp.2011.02.006. 
      Epub 2011 Apr 8.


PMID- 21481578
OWN - NLM
STAT- MEDLINE
DCOM- 20110916
LR  - 20110530
IS  - 1873-4758 (Electronic)
IS  - 0955-3959 (Linking)
VI  - 22
IP  - 3
DP  - 2011 May
TI  - Drug policy, harm and human rights: a rationalist approach.
PG  - 233-8
LID - 10.1016/j.drugpo.2011.02.003 [doi]
AB  - BACKGROUND: It has recently been argued that drug-related harms cannot be
      compared, so making it impossible to choose rationally between various drug
      policy options. Attempts to apply international human rights law to this area are
      valid, but have found it difficult to overcome the problems in applying codified 
      human rights to issues of drug policy. METHOD: This article applies the
      rationalist ethical argument of Gewirth (1978) to this issue. It outlines his
      argument to the 'principle of generic consistency' and the hierarchy of basic,
      nonsubtractive and additive rights that it entails. It then applies these ideas
      to drug policy issues, such as whether there is a right to use drugs, whether the
      rights of drug 'addicts' can be limited, and how different harms can be compared 
      in choosing between policies. RESULT: There is an additive right to use drugs,
      but only insofar as this right does not conflict with the basic and
      nonsubtractive rights of others. People whose freedom to choose whether to use
      drugs is compromised by compulsion have a right to receive treatment. They retain
      enforceable duties not to inflict harms on others. Policies which reduce harms to
      basic and nonsubtractive rights should be pursued, even if they lead to harms to 
      additive rights. CONCLUSION: There exists a sound, rational, extra-legal basis
      for the discussion of drug policy and related harms which enables commensurable
      discussion of drug policy options.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Stevens, Alex
AU  - Stevens A
AD  - School of Social Policy, Sociology and Social Research, University of Kent,
      Medway, United Kingdom. a.w.stevens@kent.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20110409
PL  - Netherlands
TA  - Int J Drug Policy
JT  - The International journal on drug policy
JID - 9014759
SB  - IM
MH  - *Drug and Narcotic Control
MH  - Harm Reduction/*ethics
MH  - *Human Rights
MH  - Humans
MH  - Internationality
MH  - Public Policy
MH  - Substance-Related Disorders/epidemiology/*prevention & control
EDAT- 2011/04/13 06:00
MHDA- 2011/09/17 06:00
CRDT- 2011/04/13 06:00
PHST- 2010/06/01 00:00 [received]
PHST- 2011/01/21 00:00 [revised]
PHST- 2011/02/04 00:00 [accepted]
PHST- 2011/04/13 06:00 [entrez]
PHST- 2011/04/13 06:00 [pubmed]
PHST- 2011/09/17 06:00 [medline]
AID - S0955-3959(11)00023-5 [pii]
AID - 10.1016/j.drugpo.2011.02.003 [doi]
PST - ppublish
SO  - Int J Drug Policy. 2011 May;22(3):233-8. doi: 10.1016/j.drugpo.2011.02.003. Epub 
      2011 Apr 9.


PMID- 21481448
OWN - NLM
STAT- MEDLINE
DCOM- 20110815
LR  - 20220409
IS  - 1474-547X (Electronic)
IS  - 0140-6736 (Linking)
VI  - 378
IP  - 9790
DP  - 2011 Aug 6
TI  - Mathematical models in the evaluation of health programmes.
PG  - 515-25
LID - 10.1016/S0140-6736(10)61505-X [doi]
AB  - Modelling is valuable in the planning and evaluation of interventions, especially
      when a controlled trial is ethically or logistically impossible. Models are often
      used to calculate the expected course of events in the absence of more formal
      assessments. They are also used to derive estimates of rare or future events from
      recorded intermediate points. When developing models, decisions are needed about 
      the appropriate level of complexity to be represented and about model structure
      and assumptions. The degree of rigor in model development and assessment can vary
      greatly, and there is a danger that existing beliefs inappropriately influence
      judgments about model assumptions and results.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Garnett, Geoffrey P
AU  - Garnett GP
AD  - Department of Infectious Disease Epidemiology, Imperial College London, London,
      UK.
FAU - Cousens, Simon
AU  - Cousens S
FAU - Hallett, Timothy B
AU  - Hallett TB
FAU - Steketee, Richard
AU  - Steketee R
FAU - Walker, Neff
AU  - Walker N
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110408
PL  - England
TA  - Lancet
JT  - Lancet (London, England)
JID - 2985213R
RN  - 0 (AIDS Vaccines)
RN  - 0 (Measles Vaccine)
RN  - 0 (Papillomavirus Vaccines)
SB  - IM
MH  - AIDS Vaccines/administration & dosage
MH  - Age Factors
MH  - *Decision Support Techniques
MH  - Epidemics/statistics & numerical data
MH  - Evaluation Studies as Topic
MH  - HIV Infections/epidemiology/prevention & control
MH  - *Health Planning
MH  - Humans
MH  - Linear Models
MH  - Measles/mortality/prevention & control
MH  - Measles Vaccine/administration & dosage
MH  - Models, Statistical
MH  - *Models, Theoretical
MH  - Papillomavirus Vaccines/administration & dosage
MH  - Program Evaluation/*methods
MH  - Quality Assurance, Health Care
MH  - Sensitivity and Specificity
MH  - Stochastic Processes
MH  - Time Factors
MH  - Uncertainty
MH  - United Kingdom
EDAT- 2011/04/13 06:00
MHDA- 2011/08/16 06:00
CRDT- 2011/04/13 06:00
PHST- 2011/04/13 06:00 [entrez]
PHST- 2011/04/13 06:00 [pubmed]
PHST- 2011/08/16 06:00 [medline]
AID - S0140-6736(10)61505-X [pii]
AID - 10.1016/S0140-6736(10)61505-X [doi]
PST - ppublish
SO  - Lancet. 2011 Aug 6;378(9790):515-25. doi: 10.1016/S0140-6736(10)61505-X. Epub
      2011 Apr 8.


PMID- 21480878
OWN - NLM
STAT- MEDLINE
DCOM- 20110824
LR  - 20110615
IS  - 1528-1167 (Electronic)
IS  - 0013-9580 (Linking)
VI  - 52
IP  - 6
DP  - 2011 Jun
TI  - The causes of epilepsy: changing concepts of etiology of epilepsy over the past
      150 years.
PG  - 1033-44
LID - 10.1111/j.1528-1167.2011.03051.x [doi]
AB  - This paper provides a survey of the changing concepts of the etiology of epilepsy
      from 1860 to 2010, focusing on the first two 50-year periods and outlining more
      briefly major developments in the past 50 years. Among the concepts reviewed in
      the first 100 years are: the division between predisposing and exciting causes,
      idiopathic and genuine epilepsy, organic epilepsy, the concept of "cause" being
      equivalent to "causal mechanism," Russell Reynolds etiological classification,
      the neurological taint and theories of degeneration, the self-perpetuating nature
      of seizures, reflex theories of etiology, autointoxication, heredity and
      eugenics, epilepsy due to brain disorders, the role of EEG and of hippocampal
      sclerosis, psychological theories of causation, and the multifactorial view of
      epilepsy etiology. In the past 50 years, the major advances in studying causation
      in epilepsy have been: clinical biochemistry, neuroimaging, molecular genetics,
      studies of mechanisms of epilepsy, better statistical methodologies and
      classification. A number of general observations can be made: the identification 
      of "cause" is not as simple as it might at first appear; progress in the study of
      causation has been often erratic and travelled up many cul-de-sacs; theories of
      causation are heavily influenced by societal influences and fashion, and is also 
      heavily dependent on applied methodologies; the recently explored possibility
      that the underlying inherited mechanisms of epilepsy are shared with other
      neuropsychiatric conditions is in effect a reinvention of the concept of the
      neurological trait, and this has ethical and social implications. Considering and
      classifying cause in terms of causal mechanism, as was suggested by Hughlings
      Jackson, is an ultimate goal.
CI  - Wiley Periodicals, Inc. (c) 2011 International League Against Epilepsy.
FAU - Shorvon, Simon D
AU  - Shorvon SD
AD  - UCL Institute of Neurology, University College London, London, UK.
      s.shorvon@ion.ucl.ac.uk
LA  - eng
PT  - Historical Article
PT  - Journal Article
DEP - 20110411
PL  - United States
TA  - Epilepsia
JT  - Epilepsia
JID - 2983306R
SB  - IM
MH  - Brain Injuries/complications/history
MH  - Electroencephalography/history
MH  - Epilepsy/etiology/*history
MH  - History, 19th Century
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Stress, Psychological/complications/history
EDAT- 2011/04/13 06:00
MHDA- 2011/08/25 06:00
CRDT- 2011/04/13 06:00
PHST- 2011/04/13 06:00 [entrez]
PHST- 2011/04/13 06:00 [pubmed]
PHST- 2011/08/25 06:00 [medline]
AID - 10.1111/j.1528-1167.2011.03051.x [doi]
PST - ppublish
SO  - Epilepsia. 2011 Jun;52(6):1033-44. doi: 10.1111/j.1528-1167.2011.03051.x. Epub
      2011 Apr 11.


PMID- 21480826
OWN - NLM
STAT- MEDLINE
DCOM- 20110912
LR  - 20190918
IS  - 1873-4316 (Electronic)
IS  - 1389-2010 (Linking)
VI  - 12
IP  - 5
DP  - 2011 May
TI  - Assessing drug transport across the human placental barrier: from in vivo and in 
      vitro measurements to the ex vivo perfusion method and in silico techniques.
PG  - 804-13
AB  - Assessing drug transport across the human placental barrier is of vital
      importance in order to guarantee drug safety during pregnancy. However, due to
      ethical reasons, in vivo fetal development risk assessment studies related to
      maternal drugs and chemicals exposure remain extremely limited. To overcome any
      ethical issues, several in vitro models applying primary trophoblastic cells,
      immortal cell lines and tissue explants of placental origin have recently been
      advanced. Alternatively, ex vivo human placental perfusion seems to be a more
      representative and highly informative method, which offers better insights into
      the different drug transporters, xenobiotic metabolism and tissue binding.
      Recently, in silico techniques have further been advanced as complementary tools 
      to validate experimental placental transfer data, offering an attractive
      alternative for high throughput screening of potential fetotoxicity at the early 
      stages of drug design. The present review scrutinizes, from a critical point of
      view, the current trends and perspectives in the emerging topic of drug transport
      across the human placental barrier. The special characteristics of the recently
      developed biopharmaceuticals on the transplacental transfer process are also
      discussed.
FAU - Giaginis, Constantinos
AU  - Giaginis C
AD  - Department of Forensic Medicine and Toxicology, Medical School, University of
      Athens, 75 Mikras Asias Street, Athens 11527, Greece. cgiaginis@yahoo.gr
FAU - Tsantili-Kakoulidou, Anna
AU  - Tsantili-Kakoulidou A
FAU - Theocharis, Stamatios
AU  - Theocharis S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Curr Pharm Biotechnol
JT  - Current pharmaceutical biotechnology
JID - 100960530
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Animals
MH  - Biological Transport
MH  - Drug Design
MH  - Female
MH  - Humans
MH  - *Maternal-Fetal Exchange
MH  - Pharmaceutical Preparations/*metabolism
MH  - Placenta/*metabolism
MH  - Pregnancy
EDAT- 2011/04/13 06:00
MHDA- 2011/09/13 06:00
CRDT- 2011/04/13 06:00
PHST- 2010/02/26 00:00 [received]
PHST- 2010/11/10 00:00 [accepted]
PHST- 2011/04/13 06:00 [entrez]
PHST- 2011/04/13 06:00 [pubmed]
PHST- 2011/09/13 06:00 [medline]
AID - BSP/CPB/E-Pub/00097-12-1 [pii]
AID - 10.2174/138920111795470930 [doi]
PST - ppublish
SO  - Curr Pharm Biotechnol. 2011 May;12(5):804-13. doi: 10.2174/138920111795470930.


PMID- 21480228
OWN - NLM
STAT- MEDLINE
DCOM- 20111102
LR  - 20110607
IS  - 1097-4679 (Electronic)
IS  - 0021-9762 (Linking)
VI  - 67
IP  - 7
DP  - 2011 Jul
TI  - Training competent psychologists in the field of child maltreatment.
PG  - 752-7
LID - 10.1002/jclp.20803 [doi]
AB  - Child maltreatment is a serious threat to children's physical and psychological
      well-being; therefore, it is critically important to develop high-quality
      educational programs to train psychologists in effectively addressing child abuse
      and neglect. Various health care disciplines and areas within the field of
      psychology have established competencies as a guide for student training
      curricula; however, none have been established for the area of child
      maltreatment. The present article presents training competencies for the field of
      child maltreatment that have been developed from a program designed to train
      psychology graduate students to practice and conduct research in child
      maltreatment. The competencies have been divided into eight core areas including 
      assessment, treatment, multidisciplinary collaboration, advocacy, ethics,
      research, research ethics, and professional development.
CI  - (c) 2011 Wiley Periodicals, Inc.
FAU - Damashek, Amy
AU  - Damashek A
AD  - Western Michigan University.
FAU - Balachova, Tatiana
AU  - Balachova T
FAU - Bonner, Barbara
AU  - Bonner B
LA  - eng
GR  - D40HP08524/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20110408
PL  - United States
TA  - J Clin Psychol
JT  - Journal of clinical psychology
JID - 0217132
SB  - IM
MH  - Child
MH  - Child Abuse/*therapy
MH  - Humans
MH  - Professional Competence/*standards
MH  - Psychology/*education
EDAT- 2011/04/12 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/04/12 06:00
PHST- 2011/04/12 06:00 [entrez]
PHST- 2011/04/12 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
AID - 10.1002/jclp.20803 [doi]
PST - ppublish
SO  - J Clin Psychol. 2011 Jul;67(7):752-7. doi: 10.1002/jclp.20803. Epub 2011 Apr 8.


PMID- 21480077
OWN - NLM
STAT- MEDLINE
DCOM- 20110606
LR  - 20191210
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 11
IP  - 4
DP  - 2011 Apr
TI  - Public health ethics and the justification of HIV screening.
PG  - 48-9
LID - 10.1080/15265161.2011.552160 [doi]
FAU - Dawson, Angus
AU  - Dawson A
AD  - Centre for Professional Ethics, School of Law, Keele University, Staffordshire
      ST55BG, United Kingdom. a.j.dawson@keele.ac.uk
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2011 Apr;11(4):31-40. PMID: 21480073
MH  - AIDS Serodiagnosis/*ethics
MH  - Centers for Disease Control and Prevention, U.S.
MH  - HIV Infections/*diagnosis
MH  - Humans
MH  - Mass Screening/*ethics/methods/standards
MH  - Practice Guidelines as Topic/standards
MH  - Public Health/*ethics/standards/trends
MH  - *Social Values
MH  - United States
EDAT- 2011/04/12 06:00
MHDA- 2011/06/07 06:00
CRDT- 2011/04/12 06:00
PHST- 2011/04/12 06:00 [entrez]
PHST- 2011/04/12 06:00 [pubmed]
PHST- 2011/06/07 06:00 [medline]
AID - 936085363 [pii]
AID - 10.1080/15265161.2011.552160 [doi]
PST - ppublish
SO  - Am J Bioeth. 2011 Apr;11(4):48-9. doi: 10.1080/15265161.2011.552160.


PMID- 21480073
OWN - NLM
STAT- MEDLINE
DCOM- 20110606
LR  - 20191210
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 11
IP  - 4
DP  - 2011 Apr
TI  - An ethical evaluation of the 2006 Centers for Disease Control and Prevention
      Recommendations for HIV testing in health care settings.
PG  - 31-40
LID - 10.1080/15265161.2011.560339 [doi]
AB  - When in 2006 the Centers for Disease Control and Prevention issued revised
      recommendations for HIV testing in health care settings, vocal opponents charged 
      that use of an "opt-out" approach to presenting HIV testing to patients; the
      implementation of nontargeted, widespread HIV screening; the elimination of a
      separate signed consent; and the decoupling of required HIV prevention counseling
      from HIV testing are unethical. Here we undertake the first systematic ethical
      examination of the arguments both for and against the recommendations. Our
      examination reveals that the ethical concerns raised by the critics predominantly
      pertain not to ethically suspect elements of the recommendations themselves, but 
      to suspicions that they will be implemented improperly. It has not been shown
      that the recommendations cannot be implemented properly. Here we show that in the
      United States the recommendations are morally justifiable and that safeguards or 
      regulatory oversight may serve to ensure that the recommendations are properly
      implemented.
FAU - Celada, M Teresa
AU  - Celada MT
AD  - Wheaton College, USA.
FAU - Merchant, Roland C
AU  - Merchant RC
FAU - Waxman, Michael J
AU  - Waxman MJ
FAU - Sherwin, Angela M
AU  - Sherwin AM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CIN - Am J Bioeth. 2011 Apr;11(4):41-3. PMID: 21480074
CIN - Am J Bioeth. 2011 Apr;11(4):43-5. PMID: 21480075
CIN - Am J Bioeth. 2011 Apr;11(4):46-8. PMID: 21480076
CIN - Am J Bioeth. 2011 Apr;11(4):48-9. PMID: 21480077
MH  - AIDS Serodiagnosis/ethics
MH  - Adolescent
MH  - Adult
MH  - Centers for Disease Control and Prevention, U.S.
MH  - Coercion
MH  - *Counseling/ethics
MH  - Ethical Analysis
MH  - HIV Infections/*diagnosis/prevention & control
MH  - Health Policy/trends
MH  - Humans
MH  - Informed Consent/*ethics/standards
MH  - Mass Screening/*ethics/methods/standards
MH  - Middle Aged
MH  - *Practice Guidelines as Topic/standards
MH  - *Public Health/standards/trends
MH  - Stereotyping
MH  - United States
MH  - Voluntary Programs
EDAT- 2011/04/12 06:00
MHDA- 2011/06/07 06:00
CRDT- 2011/04/12 06:00
PHST- 2011/04/12 06:00 [entrez]
PHST- 2011/04/12 06:00 [pubmed]
PHST- 2011/06/07 06:00 [medline]
AID - 936109252 [pii]
AID - 10.1080/15265161.2011.560339 [doi]
PST - ppublish
SO  - Am J Bioeth. 2011 Apr;11(4):31-40. doi: 10.1080/15265161.2011.560339.


PMID- 21480063
OWN - NLM
STAT- MEDLINE
DCOM- 20110606
LR  - 20140325
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 11
IP  - 4
DP  - 2011 Apr
TI  - Assessing the remedy: the case for contracts in clinical trials.
PG  - 3-12
LID - 10.1080/15265161.2011.560340 [doi]
AB  - Current orthodoxy in research ethics assumes that subjects of clinical trials
      reserve rights to withdraw at any time and without giving any reason. This view
      sees the right to withdraw as a simple extension of the right to refuse to
      participate all together. In this paper, however, I suggest that subjects should 
      assume some responsibilities for the internal validity of the trial at consent
      and that these responsibilities should be captured by contract. This would allow 
      the researcher to impose a penalty on the subject if he were to withdraw without 
      good reason and on a whim. This proposal still leaves open the possibility of
      withdrawing without penalty when it is in the subject's best interests to do so. 
      Giving researchers recourse to legal remedy may now be necessary to protect the
      science, as existing methods used to increase retention are inadequate for one
      reason or another.
FAU - Edwards, Sarah J L
AU  - Edwards SJ
AD  - Centre for Philosophy, Justice and Health, University College London, London
      W1W7EJ, United Kingdom. sarah.edwards@ucl.ac.uk
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CIN - Am J Bioeth. 2011 Apr;11(4):W1-3. PMID: 21480062
CIN - Am J Bioeth. 2011 Apr;11(4):13-4. PMID: 21480064
CIN - Am J Bioeth. 2011 Apr;11(4):14-6. PMID: 21480065
CIN - Am J Bioeth. 2011 Apr;11(4):16-8. PMID: 21480066
CIN - Am J Bioeth. 2011 Apr;11(4):18-20. PMID: 21480067
CIN - Am J Bioeth. 2011 Apr;11(4):20-1. PMID: 21480068
CIN - Am J Bioeth. 2011 Apr;11(4):22-3. PMID: 21480069
CIN - Am J Bioeth. 2011 Apr;11(4):24-5. PMID: 21480070
CIN - Am J Bioeth. 2011 Apr;11(4):25-7. PMID: 21480071
CIN - Am J Bioeth. 2011 Apr;11(4):27-30. PMID: 21480072
MH  - Clinical Trials as Topic/*ethics
MH  - Contracts/*ethics
MH  - Ethics Committees, Research
MH  - Ethics, Research
MH  - Freedom
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Patient Dropouts/*legislation & jurisprudence
MH  - Patient Rights/ethics
MH  - Physician-Patient Relations/ethics
MH  - Reproducibility of Results
MH  - Research Personnel/*ethics/legislation & jurisprudence
MH  - Research Subjects/*legislation & jurisprudence
MH  - Researcher-Subject Relations/*ethics
MH  - Volunteers
EDAT- 2011/04/12 06:00
MHDA- 2011/06/07 06:00
CRDT- 2011/04/12 06:00
PHST- 2011/04/12 06:00 [entrez]
PHST- 2011/04/12 06:00 [pubmed]
PHST- 2011/06/07 06:00 [medline]
AID - 936101829 [pii]
AID - 10.1080/15265161.2011.560340 [doi]
PST - ppublish
SO  - Am J Bioeth. 2011 Apr;11(4):3-12. doi: 10.1080/15265161.2011.560340.


PMID- 21479827
OWN - NLM
STAT- MEDLINE
DCOM- 20120315
LR  - 20211020
IS  - 1708-0428 (Electronic)
IS  - 0960-8923 (Linking)
VI  - 21
IP  - 9
DP  - 2011 Sep
TI  - Ethical issues of obesity surgery--a health technology assessment.
PG  - 1469-76
LID - 10.1007/s11695-011-0386-1 [doi]
AB  - New surgical technologies may challenge societal values, and their adoption may
      lead to ethical challenges. Despite proven cost-effectiveness, obesity
      (bariatric) surgery and its public funding have been questioned on ethical
      arguments relating to, for example, the self-inflicted or non-disease nature of
      obesity. Our aim was to analyze the ethical issues relevant to bariatric surgery.
      A comprehensive health technology assessment was conducted on bariatric surgery
      for morbid obesity using the EUnetHTA method, including a fully integrated
      ethical analysis. The ethical arguments suggesting that obesity should not be
      surgically treated because it is self-inflicted were rejected. Medicalization of 
      obesity may have both positive and negative effects that impact the various
      stakeholders differently, thus being difficult to balance. Informing bariatric
      surgery patients and actively supporting their autonomy is exceptionally
      important, as the benefits and harms of both obesity and bariatric surgery are
      complex, and the outcome depends on how well the patient understands and adheres 
      to the life-long changes in eating habits required. Justice considerations are
      important in organizing surgical treatment of obesity, as the obese are
      discriminated against in many ways and obesity is more common in
      socioeconomically disadvantaged populations who might have problems of access to 
      treatments. Obesity should be treated like other diseases in health care, and
      obesity surgery rationed like other cost-effective treatments. Positive actions
      to ensure patient autonomy and just access to surgical treatments may be
      warranted.
FAU - Saarni, Samuli I
AU  - Saarni SI
AD  - Department of Mental Health and Substance Abuse Services, National Institute for 
      Health and Welfare, Helsinki, Finland. samuli.saarni@helsinki.fi
FAU - Anttila, Heidi
AU  - Anttila H
FAU - Saarni, Suoma E
AU  - Saarni SE
FAU - Mustajoki, Pertti
AU  - Mustajoki P
FAU - Koivukangas, Vesa
AU  - Koivukangas V
FAU - Ikonen, Tuija S
AU  - Ikonen TS
FAU - Malmivaara, Antti
AU  - Malmivaara A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Obes Surg
JT  - Obesity surgery
JID - 9106714
SB  - IM
MH  - Bariatric Surgery/economics/*ethics
MH  - Diet
MH  - Humans
MH  - Obesity/*surgery
MH  - Personal Autonomy
MH  - Prejudice
MH  - Social Justice
MH  - Social Responsibility
MH  - Social Values
MH  - Socioeconomic Factors
MH  - Technology Assessment, Biomedical
EDAT- 2011/04/12 06:00
MHDA- 2012/03/16 06:00
CRDT- 2011/04/12 06:00
PHST- 2011/04/12 06:00 [entrez]
PHST- 2011/04/12 06:00 [pubmed]
PHST- 2012/03/16 06:00 [medline]
AID - 10.1007/s11695-011-0386-1 [doi]
PST - ppublish
SO  - Obes Surg. 2011 Sep;21(9):1469-76. doi: 10.1007/s11695-011-0386-1.


PMID- 21479794
OWN - NLM
STAT- MEDLINE
DCOM- 20110919
LR  - 20211020
IS  - 1573-0980 (Electronic)
IS  - 1386-7415 (Linking)
VI  - 32
IP  - 4
DP  - 2011 Aug
TI  - The placebo phenomenon and medical ethics: rethinking the relationship between
      informed consent and risk-benefit assessment.
PG  - 229-43
LID - 10.1007/s11017-011-9179-8 [doi]
AB  - It has been presumed within bioethics that the benefits and risks of treatments
      can be assessed independently of information disclosure to patients as part of
      the informed consent process. Research on placebo and nocebo effects indicates
      that this is not true for symptomatic treatments. The benefits and risks that
      patients experience from symptomatic treatments can be shaped powerfully by
      information about these treatments provided by clinicians. In this paper we
      discuss the implications of placebo and nocebo research for risk-benefit
      assessment and informed consent.
FAU - Miller, Franklin G
AU  - Miller FG
AD  - Department of Bioethics Clinical Center, National Institutes of Health, Building 
      10, Bethesda, MD 20892-1156, USA. fmiller@nih.gov
FAU - Colloca, Luana
AU  - Colloca L
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PL  - Netherlands
TA  - Theor Med Bioeth
JT  - Theoretical medicine and bioethics
JID - 9805378
SB  - IM
MH  - Color Perception
MH  - Controlled Clinical Trials as Topic/*ethics
MH  - Ethics, Medical
MH  - Ethics, Research
MH  - Humans
MH  - *Informed Consent/ethics/psychology
MH  - Pain Perception
MH  - *Personal Autonomy
MH  - *Placebo Effect
MH  - *Research Subjects/psychology
MH  - *Risk Assessment
MH  - Truth Disclosure
EDAT- 2011/04/12 06:00
MHDA- 2011/09/20 06:00
CRDT- 2011/04/12 06:00
PHST- 2011/04/12 06:00 [entrez]
PHST- 2011/04/12 06:00 [pubmed]
PHST- 2011/09/20 06:00 [medline]
AID - 10.1007/s11017-011-9179-8 [doi]
PST - ppublish
SO  - Theor Med Bioeth. 2011 Aug;32(4):229-43. doi: 10.1007/s11017-011-9179-8.


PMID- 21478423
OWN - NLM
STAT- MEDLINE
DCOM- 20120103
LR  - 20110620
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 7
DP  - 2011 Jul
TI  - Double effect: a useful rule that alone cannot justify hastening death.
PG  - 437-40
LID - 10.1136/jme.2010.041160 [doi]
AB  - The rule of double effect is regularly invoked in ethical discussions about
      palliative sedation, terminal extubation and other clinical acts that may be
      viewed as hastening death for imminently dying patients. Unfortunately, the
      literature tends to employ this useful principle in a fashion suggesting that it 
      offers the final word on the moral acceptability of such medical procedures. In
      fact, the rule cannot be applied appropriately without invoking moral theories
      that are not explicit in the rule itself. Four tenets of the rule each require
      their own ethical justification. A variety of moral theories are relevant to
      making judgements in a pluralistic society. Much of the rich moral conversation
      germane to the rule has been reflected in arguments about physician-assisted
      suicide and voluntary active euthanasia, but the rule itself has limited
      relevance to these debates, and requires its own moral justifications when
      applied to other practices that might hasten death.
FAU - Billings, J Andrew
AU  - Billings JA
AD  - jandrew.billings@gmail.com
LA  - eng
PT  - Journal Article
DEP - 20110408
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Double Effect Principle
MH  - *Ethics, Medical
MH  - Euthanasia/*ethics
MH  - Humans
MH  - *Philosophy, Medical
EDAT- 2011/04/12 06:00
MHDA- 2012/01/04 06:00
CRDT- 2011/04/12 06:00
PHST- 2011/04/12 06:00 [entrez]
PHST- 2011/04/12 06:00 [pubmed]
PHST- 2012/01/04 06:00 [medline]
AID - jme.2010.041160 [pii]
AID - 10.1136/jme.2010.041160 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Jul;37(7):437-40. doi: 10.1136/jme.2010.041160. Epub 2011 Apr 
      8.


PMID- 21478422
OWN - NLM
STAT- MEDLINE
DCOM- 20120224
LR  - 20151119
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 9
DP  - 2011 Sep
TI  - Patients' perspectives of the substitute decision maker: who makes better
      decisions?
PG  - 523-5
LID - 10.1136/jme.2010.040691 [doi]
AB  - INTRODUCTION: Substitute decision making on behalf of incapable patients is based
      on the ethical principle of 'respect for autonomy'. This study was conducted to
      assess patients' wishes and preferences in terms of a substitute decision maker
      and determinants of such preferences. METHODS: The authors conducted a
      cross-sectional study and selected samples randomly from patients presenting at
      Farabi Eye Hospital clinics who were 18&emsp14;years of age or older.
      Questionnaires were completed through interviews. RESULTS: 200 patients between
      the ages of 18 and 83&emsp14;years were interviewed. About 52% (N=105) were men
      and 73% (N=77) were married. Among married patients, the spouse was chosen as the
      substitute decision maker in only 51% of cases. Single men preferred their father
      first in 36% (N=9) of cases, while single girls chose their father in 5.6% (N=1) 
      of cases and their most prevalent choice was other unmentioned people (33.3%,
      N=6). Most patients (93.5%) wished to be asked about their substitute decision
      maker when hospitalised. CONCLUSION: The results of this study show that the
      people we usually consult for decisions concerning patient treatment are
      significantly different from the patients' preferred substitute decision makers. 
      The authors suggest patients be allowed to choose their substitute decision maker
      while conscious.
FAU - Mirzaei, Komeil
AU  - Mirzaei K
AD  - Department of Surgery, Facultyof Medicine, Tehran Universityof Medical Sciences, 
      Tehran, Iran.
FAU - Milanifar, Alireza
AU  - Milanifar A
FAU - Asghari, Fariba
AU  - Asghari F
LA  - eng
PT  - Journal Article
DEP - 20110408
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Advance Directives/trends
MH  - Aged
MH  - Aged, 80 and over
MH  - Cross-Sectional Studies/methods
MH  - Decision Making/*ethics
MH  - Ethics, Clinical
MH  - Female
MH  - Humans
MH  - Iran
MH  - Male
MH  - Middle Aged
MH  - *Patient Participation
MH  - Patient Preference
MH  - Personal Autonomy
MH  - Physician-Patient Relations
MH  - Surveys and Questionnaires
MH  - Third-Party Consent/*ethics
MH  - Young Adult
EDAT- 2011/04/12 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/04/12 06:00
PHST- 2011/04/12 06:00 [entrez]
PHST- 2011/04/12 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - jme.2010.040691 [pii]
AID - 10.1136/jme.2010.040691 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Sep;37(9):523-5. doi: 10.1136/jme.2010.040691. Epub 2011 Apr
      8.


PMID- 21478420
OWN - NLM
STAT- MEDLINE
DCOM- 20120224
LR  - 20110822
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 9
DP  - 2011 Sep
TI  - The 'patient's physician one-step removed': the evolving roles of medical tourism
      facilitators.
PG  - 530-4
LID - 10.1136/jme.2011.042374 [doi]
AB  - BACKGROUND: Medical tourism involves patients travelling internationally to
      receive medical services. This practice raises a range of ethical issues,
      including potential harms to the patient's home and destination country and risks
      to the patient's own health. Medical tourists often engage the services of a
      facilitator who may book travel and accommodation and link the patient with a
      hospital abroad. Facilitators have the potential to exacerbate or mitigate the
      ethical concerns associated with medical tourism, but their roles are poorly
      understood. METHODS: 12 facilitators were interviewed from 10 Canadian medical
      tourism companies. RESULTS: Three themes were identified: facilitators' roles
      towards the patient, health system and medical tourism industry. Facilitators'
      roles towards the patient were typically described in terms of advocacy and the
      provision of information, but limited by facilitators' legal liability.
      Facilitators felt they played a positive role in the lives of their patients and 
      the Canadian health system and served as catalysts for reform, although they
      noted an adversarial relationship with some Canadian physicians. Many
      facilitators described personally visiting medical tourism sites and forming
      personal relationships with surgeons abroad, but noted the need for greater
      regulation of their industry. CONCLUSION: Facilitators play a substantial and
      evolving role in the practice of medical tourism and may be entering a period of 
      professionalisation. Because of the key role of facilitators in determining the
      effects of medical tourism on patients and public health, this paper recommends a
      planned conversation between medical tourism stakeholders to define and shape
      facilitators' roles.
FAU - Snyder, Jeremy
AU  - Snyder J
AD  - Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada.
      jcs12@sfu.ca
FAU - Crooks, Valorie A
AU  - Crooks VA
FAU - Adams, Krystyna
AU  - Adams K
FAU - Kingsbury, Paul
AU  - Kingsbury P
FAU - Johnston, Rory
AU  - Johnston R
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20110408
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Adult
MH  - Canada
MH  - Communication
MH  - Continuity of Patient Care/standards
MH  - *Ethics, Medical
MH  - Health Care Sector/*ethics
MH  - Humans
MH  - Interviews as Topic
MH  - Marketing of Health Services/*ethics/*standards
MH  - Medical Tourism/*ethics
MH  - Physician-Patient Relations
MH  - Public Health
MH  - Role
MH  - Social Control, Formal
MH  - Travel
EDAT- 2011/04/12 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/04/12 06:00
PHST- 2011/04/12 06:00 [entrez]
PHST- 2011/04/12 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - jme.2011.042374 [pii]
AID - 10.1136/jme.2011.042374 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Sep;37(9):530-4. doi: 10.1136/jme.2011.042374. Epub 2011 Apr
      8.


PMID- 21478417
OWN - NLM
STAT- MEDLINE
DCOM- 20120224
LR  - 20110822
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 9
DP  - 2011 Sep
TI  - Human dignity and human tissue: a meaningful ethical relationship?
PG  - 552-6
LID - 10.1136/jme.2010.041509 [doi]
AB  - Human dignity has long been used as a foundational principle in policy documents 
      and ethical guidelines intended to govern various forms of biomedical research.
      Despite the vast amount of literature concerning human dignity and embryonic
      tissues, the majority of biomedical research uses non-embryonic human tissue.
      Therefore, this contribution addresses a notable lacuna in the literature: the
      relationship, if any, between human dignity and human tissue. This paper first
      elaborates a multidimensional understanding of human dignity that overcomes many 
      of the shortcomings associated with the use of human dignity in other ethical
      debates. Second, it discusses the relationship between such an understanding of
      human dignity and 'non-embryonic' human tissue. Finally, it considers the
      implications of this relationship for biomedical research and practice involving 
      human tissue. The contribution demonstrates that while human tissue cannot be
      said to have human dignity, human dignity is nevertheless implicated by human
      tissue, making what is done with human tissue and how it is done worthy of moral 
      consideration.
FAU - Kirchhoffer, David G
AU  - Kirchhoffer DG
AD  - Centre for Biomedical Ethics and Law, Katholieke Universiteit Leuven,
      Kapucijnenvoer 35 Blok D-bus 7001, Leuven 3000, Belgium.
FAU - Dierickx, Kris
AU  - Dierickx K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110408
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Ethics, Research
MH  - Human Experimentation/*ethics
MH  - Human Rights/psychology
MH  - Humans
MH  - Morals
MH  - *Personhood
MH  - Research/standards
MH  - Self Concept
MH  - Stem Cell Research/ethics
EDAT- 2011/04/12 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/04/12 06:00
PHST- 2011/04/12 06:00 [entrez]
PHST- 2011/04/12 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - jme.2010.041509 [pii]
AID - 10.1136/jme.2010.041509 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Sep;37(9):552-6. doi: 10.1136/jme.2010.041509. Epub 2011 Apr
      8.


PMID- 21478327
OWN - NLM
STAT- MEDLINE
DCOM- 20110822
LR  - 20211203
IS  - 1740-7753 (Electronic)
IS  - 1740-7745 (Linking)
VI  - 8
IP  - 2
DP  - 2011 Apr
TI  - The effect of heterogeneity on HIV prevention trials.
PG  - 144-54
LID - 10.1177/1740774511398923 [doi]
AB  - BACKGROUND: Randomized controlled trials (RCTs) for the prevention of HIV
      heterosexual acquisition are usually conducted among adult African populations
      with high heterogeneity in individual risk of infection. PURPOSE: The objectives 
      were to (a) review how this heterogeneity has been considered when designing and 
      interpreting such RCTs, (b) evaluate its effect on the findings and the
      statistical power of these trials, and (c) assess the potential advantages of
      using the crossover design with single failure-time endpoint. METHODS:
      Individual-level HIV prevention RCTs conducted in Africa and published in the
      period 1998-2008 were reviewed. Using Monte Carlo simulations and statistical
      calculations, we assessed the effect of heterogeneity on the findings and the
      statistical power of HIV prevention RCTs. RESULTS: All reviewed RCTs used the
      parallel design. The heterogeneity in individual risk of infection within study
      sites was not used for stratification nor generally considered in the design and 
      interpretation of RCTs. Simulations showed that in the context of high HIV
      incidence, high heterogeneity can lead to a substantial underestimation of the
      impact of an intervention and reduced statistical power. Calculations
      demonstrated that the crossover design allowed for similar or better estimation
      and statistical power. The crossover design has the ethical advantage of sharing 
      the potential benefits and risks of the intervention between participants.
      LIMITATIONS: Only trials with two treatment arms and two follow-up periods were
      modeled. The baseline risk of infection of each participant was assumed to be
      constant over time and HIV status was assessed at the end of each follow-up
      period. CONCLUSIONS: The heterogeneity in individual risk of HIV infection is an 
      underestimated problem which should be taken into account when designing and
      interpreting RCTs that test prevention methods of HIV heterosexual acquisition in
      adult African populations with high HIV incidence. When the effects of tested
      interventions are rapidly reversible, the use of the crossover design should be
      considered.
FAU - Auvert, Bertran
AU  - Auvert B
AD  - INSERM U1018, Villejuif, France. Bertran.auvert@uvsq.fr
FAU - Sitta, Remi
AU  - Sitta R
FAU - Zarca, Kevin
AU  - Zarca K
FAU - Mahiane, Severin Guy
AU  - Mahiane SG
FAU - Pretorius, Carel
AU  - Pretorius C
FAU - Lissouba, Pascale
AU  - Lissouba P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Clin Trials
JT  - Clinical trials (London, England)
JID - 101197451
SB  - IM
MH  - Adult
MH  - Africa South of the Sahara
MH  - Blacks
MH  - Computer Simulation
MH  - Cross-Over Studies
MH  - Female
MH  - HIV Infections/*prevention & control/*transmission
MH  - Heterosexuality
MH  - Humans
MH  - Individuality
MH  - Male
MH  - *Models, Statistical
MH  - Randomized Controlled Trials as Topic/*methods
MH  - Research Design
MH  - Risk Factors
MH  - Sexual Partners
EDAT- 2011/04/12 06:00
MHDA- 2011/08/23 06:00
CRDT- 2011/04/12 06:00
PHST- 2011/04/12 06:00 [entrez]
PHST- 2011/04/12 06:00 [pubmed]
PHST- 2011/08/23 06:00 [medline]
AID - 8/2/144 [pii]
AID - 10.1177/1740774511398923 [doi]
PST - ppublish
SO  - Clin Trials. 2011 Apr;8(2):144-54. doi: 10.1177/1740774511398923.


PMID- 21477981
OWN - NLM
STAT- MEDLINE
DCOM- 20111212
LR  - 20151119
IS  - 1873-6513 (Electronic)
IS  - 0885-3924 (Linking)
VI  - 42
IP  - 1
DP  - 2011 Jul
TI  - Palliative treatment alternatives and euthanasia consultations: a qualitative
      interview study.
PG  - 32-43
LID - 10.1016/j.jpainsymman.2010.10.260 [doi]
AB  - CONTEXT: There is much debate about euthanasia within the context of palliative
      care. The six criteria of careful practice for lawful euthanasia in The
      Netherlands aim to safeguard the euthanasia practice against abuse and a
      disregard of palliative treatment alternatives. Those criteria need to be
      evaluated by the treating physician as well as an independent euthanasia
      consultant. OBJECTIVES: To investigate 1) whether and how palliative treatment
      alternatives come up during or preceding euthanasia consultations and 2) how the 
      availability of possible palliative treatment alternatives are assessed by the
      independent consultant. METHODS: We interviewed 14 euthanasia consultants and 12 
      physicians who had requested a euthanasia consultation. We transcribed and
      analyzed the interviews and held consensus meetings about the interpretation.
      RESULTS: Treating physicians generally discuss the whole range of treatment
      options with the patient before the euthanasia consultation. Consultants actively
      start thinking about and proposing palliative treatment alternatives after
      consultations, when they have concluded that the criteria for careful practice
      have not been met. During the consultation, they take into account various
      aspects while assessing the criterion concerning the availability of reasonable
      alternatives, and they clearly distinguish between euthanasia and continuous deep
      sedation. Most consultants said that it was necessary to verify which forms of
      palliative care had previously been discussed. Advice concerning palliative care 
      seemed to be related to the timing of the consultation ("early" or "late").
      Euthanasia consultants were sometimes unsure whether or not to advise about
      palliative care, considering it not their task or inappropriate in view of the
      previous discussions. CONCLUSION: Two different roles of a euthanasia consultant 
      were identified: a limited one, restricted to the evaluation of the criteria for 
      careful practice, and a broad one, extended to actively providing advice about
      palliative care. Further medical and ethical debate is needed to determine
      consultants' most appropriate role.
CI  - Copyright (c) 2011 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. 
      All rights reserved.
FAU - Buiting, Hilde M
AU  - Buiting HM
AD  - VU University Medical Center, EMGO Institute for Health and Care Research,
      Department of Public and Occupational Health, Expertise Center for Palliative
      Care, Amsterdam, The Netherlands. h.buiting@vumc.nl
FAU - Willems, Dick L
AU  - Willems DL
FAU - Pasman, H Roeline W
AU  - Pasman HR
FAU - Rurup, Mette L
AU  - Rurup ML
FAU - Onwuteaka-Philipsen, Bregje D
AU  - Onwuteaka-Philipsen BD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110407
PL  - United States
TA  - J Pain Symptom Manage
JT  - Journal of pain and symptom management
JID - 8605836
SB  - IM
MH  - Euthanasia, Active, Voluntary/*ethics
MH  - Humans
MH  - Interviews as Topic
MH  - Netherlands
MH  - Palliative Care/*ethics
MH  - Physicians
MH  - *Practice Patterns, Physicians'
MH  - Qualitative Research
MH  - *Referral and Consultation
EDAT- 2011/04/12 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/04/12 06:00
PHST- 2010/05/12 00:00 [received]
PHST- 2010/09/29 00:00 [revised]
PHST- 2010/10/06 00:00 [accepted]
PHST- 2011/04/12 06:00 [entrez]
PHST- 2011/04/12 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - S0885-3924(11)00017-0 [pii]
AID - 10.1016/j.jpainsymman.2010.10.260 [doi]
PST - ppublish
SO  - J Pain Symptom Manage. 2011 Jul;42(1):32-43. doi:
      10.1016/j.jpainsymman.2010.10.260. Epub 2011 Apr 7.


PMID- 21477825
OWN - NLM
STAT- MEDLINE
DCOM- 20111128
LR  - 20161109
IS  - 1578-178X (Electronic)
IS  - 0033-8338 (Linking)
VI  - 53
IP  - 3
DP  - 2011 May-Jun
TI  - [Training in noninterpretive skills and radioprotection].
PG  - 220-5
LID - 10.1016/j.rx.2010.12.006 [doi]
AB  - Noninterpretive skills comprise a set of knowledge, skills, and attitudes
      considered necessary for residents to acquire. Important Noninterpretative skills
      include radioprotection, statistics, scientific communication, research
      methodology, critical reading of the scientific literature, ethics, legislation
      about medical issues, communicating with patients and other professionals, and
      management and quality control. The lack of specific dedication to these subjects
      in undergraduate medical education means that this training is being carried out 
      by the regional governments through the "Complementary Common Program".
CI  - Copyright (c) 2010 SERAM. Published by Elsevier Espana. All rights reserved.
FAU - Puig, J
AU  - Puig J
AD  - Servicio de Diagnostico por Imagen, UDIAT CD, Corporacio Sanitaria Parc Tauli,
      Sabadell, Barcelona, Espana. jpuig@tauli.cat
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Formacion en habilidades complementarias y Radioproteccion.
DEP - 20110407
PL  - Spain
TA  - Radiologia
JT  - Radiologia
JID - 0120775
SB  - IM
MH  - Curriculum
MH  - *Health Knowledge, Attitudes, Practice
MH  - *Internship and Residency
MH  - *Radiation Protection
MH  - Radiology/*education
EDAT- 2011/04/12 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/04/12 06:00
PHST- 2010/10/13 00:00 [received]
PHST- 2010/12/11 00:00 [revised]
PHST- 2010/12/14 00:00 [accepted]
PHST- 2011/04/12 06:00 [entrez]
PHST- 2011/04/12 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0033-8338(11)00055-5 [pii]
AID - 10.1016/j.rx.2010.12.006 [doi]
PST - ppublish
SO  - Radiologia. 2011 May-Jun;53(3):220-5. doi: 10.1016/j.rx.2010.12.006. Epub 2011
      Apr 7.


PMID- 21477643
OWN - NLM
STAT- MEDLINE
DCOM- 20121010
LR  - 20151119
IS  - 1879-3169 (Electronic)
IS  - 0378-4274 (Linking)
VI  - 213
IP  - 1
DP  - 2012 Aug 13
TI  - The use of biomarkers in occupational health research, practice, and policy.
PG  - 91-9
LID - 10.1016/j.toxlet.2011.03.027 [doi]
AB  - Biomarkers are potentially useful tools for occupational health and safety
      research, practice, and policy. However, the full realization of this potential
      has not been achieved. In this paper, the progress made in these three usage
      areas is reviewed to identify what efforts can be taken to realize the full
      promise of biomarkers. Biomarker uses are described by a diverse taxonomy that
      builds on the categories of exposure, effect and susceptibility, and the
      continuum between exposure and disease prognosis. The most significant uses of
      biomarkers in occupational health have been in biological monitoring of workers. 
      Other important uses have been in enhancing research and assessing mechanisms of 
      action of occupational toxicants at low exposures. Seven critical areas will
      influence the extent to which the potential of biomarkers in occupational health 
      and safety is realized. These include: (1) adequate investment in validation; (2)
      obtaining international agreement on exposure guidelines; (3) exploring the
      utility of biomarkers in regulation; (4) applying biomarkers to critical
      occupational safety and health questions; (5) developing the exposome; (6)
      utilizing biomarkers to address emerging occupational health issues; and (7)
      continuing to address the ethical and social justice issues related to
      biomarkers. Overall, if biomarkers are to make a major contribution to
      occupational health and safety then a more holistic approach to bringing them
      from the laboratory to practice will be needed.
CI  - Published by Elsevier Ireland Ltd.
FAU - Schulte, P A
AU  - Schulte PA
AD  - National Institute for Occupational Safety and Health, 4676 Columbia Parkway,
      Cincinnati, OH 45226, USA. PSchulte@cdc.gov
FAU - Hauser, J E
AU  - Hauser JE
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110406
PL  - Netherlands
TA  - Toxicol Lett
JT  - Toxicology letters
JID - 7709027
RN  - 0 (Biomarkers)
SB  - IM
MH  - Biomarkers/*analysis
MH  - *Health Policy
MH  - Humans
MH  - Occupational Diseases/chemically induced/diagnosis
MH  - Occupational Exposure/*analysis
MH  - Occupational Health
EDAT- 2011/04/12 06:00
MHDA- 2012/10/12 06:00
CRDT- 2011/04/12 06:00
PHST- 2011/01/28 00:00 [received]
PHST- 2011/03/25 00:00 [accepted]
PHST- 2011/04/12 06:00 [entrez]
PHST- 2011/04/12 06:00 [pubmed]
PHST- 2012/10/12 06:00 [medline]
AID - S0378-4274(11)00126-3 [pii]
AID - 10.1016/j.toxlet.2011.03.027 [doi]
PST - ppublish
SO  - Toxicol Lett. 2012 Aug 13;213(1):91-9. doi: 10.1016/j.toxlet.2011.03.027. Epub
      2011 Apr 6.


PMID- 21477522
OWN - NLM
STAT- MEDLINE
DCOM- 20110830
LR  - 20180126
IS  - 2444-054X (Electronic)
IS  - 0009-7411 (Linking)
VI  - 79
IP  - 1
DP  - 2011 Jan-Feb
TI  - [Surgical laboratory in pregraduate medicine.]
PG  - 75-82
AB  - Surgical laboratory in pregraduate students in medicine is beneficial and
      improves learning processes in cognitive aspects and skills acquisition. It is
      also an early initiation into scientific research. The laboratory is the
      introductory pathway into basic concepts of medical science (meaningful
      learning). It is also where students gain knowledge in procedures and abilities
      to obtain professional skills, an interactive teacher-student process. Medicine
      works rapidly to change from an art to a science. This fact compromises all
      schools and medical faculties to analyze their actual lesson plans. Simulators
      give students confidence and ability and save time, money and resources,
      eliminating at the same time the ethical factor of using live animals and the
      fear of patient safety. Multimedia programs may give a cognitive context evolving
      logically with an explanation based on written and visual animation followed by a
      clinical problem and its demonstration in a simulator, all before applying
      knowledge to the patient.
FAU - Tapia-Jurado, Jesus
AU  - Tapia-Jurado J
AD  - Departamento de Cirugia, Facultad de Medicina, Universidad Nacional Autonoma de
      Mexico, Mexico, DF Mexico. tapiajj@amcg.org.mx
LA  - eng
LA  - spa
PT  - Journal Article
PL  - Mexico
TA  - Cir Cir
JT  - Cirugia y cirujanos
JID - 0372736
SB  - IM
MH  - Computer Simulation
MH  - Curriculum
MH  - *Education, Medical, Undergraduate
MH  - General Surgery/*education
MH  - Laboratories
MH  - Models, Animal
EDAT- 2011/04/12 06:00
MHDA- 2011/08/31 06:00
CRDT- 2011/04/12 06:00
PHST- 2011/04/12 06:00 [entrez]
PHST- 2011/04/12 06:00 [pubmed]
PHST- 2011/08/31 06:00 [medline]
PST - ppublish
SO  - Cir Cir. 2011 Jan-Feb;79(1):75-82.


PMID- 21477521
OWN - NLM
STAT- MEDLINE
DCOM- 20110830
LR  - 20180126
IS  - 2444-054X (Electronic)
IS  - 0009-7411 (Linking)
VI  - 79
IP  - 1
DP  - 2011 Jan-Feb
TI  - [The role of surgical education in pregraduate medical education.]
PG  - 70-4
AB  - Surgical education in pregraduate medicine is important because it is during this
      period where students acquire abilities that will allow them to make important
      future decisions when performing surgical procedures. Faculties of medicine make 
      significant efforts to design innovative and rigorous curricula that will provide
      medical professionals with abilities to carryout medical procedures in a changing
      panorama of health systems as well as to provide scientific and technological
      advances. Intellectual and clinical proficiency, discipline, ethics and human
      values that a student acquires during pregraduate training and education will
      result in becoming a very efficient health professional.
FAU - Patino-Restrepo, Jose Felix
AU  - Patino-Restrepo JF
AD  - Departamento de Cirugia, Hospital Universitario, Fundacion Santa Fe de Bogota,
      Colombia. jfpatinore@gmail.com
LA  - eng
LA  - spa
PT  - Journal Article
PL  - Mexico
TA  - Cir Cir
JT  - Cirugia y cirujanos
JID - 0372736
SB  - IM
CIN - Cir Cir. 2013 May-Jun;81(3):262-3. PMID: 23769259
CIN - Cir Cir. 2013 May-Jun;81(3):262. PMID: 23946973
MH  - *Education, Medical, Undergraduate
MH  - General Surgery/*education
EDAT- 2011/04/12 06:00
MHDA- 2011/08/31 06:00
CRDT- 2011/04/12 06:00
PHST- 2011/04/12 06:00 [entrez]
PHST- 2011/04/12 06:00 [pubmed]
PHST- 2011/08/31 06:00 [medline]
PST - ppublish
SO  - Cir Cir. 2011 Jan-Feb;79(1):70-4.


PMID- 21477223
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20110525
IS  - 1540-8159 (Electronic)
IS  - 0147-8389 (Linking)
VI  - 34
IP  - 5
DP  - 2011 May
TI  - Ethics in electrophysiology: can you handle the truth?
PG  - 528-30
LID - 10.1111/j.1540-8159.2011.03079.x [doi]
AB  - A case is presented examining the need to disclose the truth in cases where there
      is a question of device and personnel performance. This case examines the
      responsibilities of physicians to their patients and the community at large to
      disclose factual accounts of events, even in the case of medical error and
      potential liability.
CI  - (c)2011, The Author. Journal compilation (c)2011 Wiley Periodicals, Inc.
FAU - Beauregard, Lou-Anne M
AU  - Beauregard LA
AD  - Heart Specialists of Central Jersey, Manalapan, New Jersey, USA.
      drbeauregard@gmail.com
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20110408
PL  - United States
TA  - Pacing Clin Electrophysiol
JT  - Pacing and clinical electrophysiology : PACE
JID - 7803944
SB  - IM
MH  - Aged
MH  - Defibrillators, Implantable
MH  - Electrocardiography
MH  - Electrophysiologic Techniques, Cardiac/*ethics
MH  - Emergency Medical Services/*ethics
MH  - *Ethics, Medical
MH  - Fatal Outcome
MH  - Humans
MH  - Male
MH  - Primary Prevention
MH  - Professional-Family Relations/*ethics
MH  - Tachycardia, Ventricular/*physiopathology/*prevention & control
EDAT- 2011/04/12 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/04/12 06:00
PHST- 2011/04/12 06:00 [entrez]
PHST- 2011/04/12 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 10.1111/j.1540-8159.2011.03079.x [doi]
PST - ppublish
SO  - Pacing Clin Electrophysiol. 2011 May;34(5):528-30. doi:
      10.1111/j.1540-8159.2011.03079.x. Epub 2011 Apr 8.


PMID- 21477117
OWN - NLM
STAT- MEDLINE
DCOM- 20111109
LR  - 20161125
IS  - 1365-2648 (Electronic)
IS  - 0309-2402 (Linking)
VI  - 67
IP  - 9
DP  - 2011 Sep
TI  - The value of reflexivity in resolving ethical dilemmas research in care homes.
PG  - 2068-77
LID - 10.1111/j.1365-2648.2011.05632.x [doi]
AB  - AIM: This paper highlights ethical dilemmas experienced by researchers when
      undertaking qualitative inquiry with vulnerable older people in care homes.
      Scenarios from research that adopted a constructivist approach illustrate a range
      of ethical dilemmas and propose practical strategies. BACKGROUND: The importance 
      of ethical comportment within qualitative inquiry is uncontested within the
      literature. Ethical guidelines exist to support qualitative researchers, but
      there appears limited consensus on how these are applied. Subsequently, ethical
      conduct in qualitative research relies heavily on researcher reflexivity and the 
      development of positive relationships with participants. Although these aspects
      are widely recognized, there is limited literature on how this is achieved in the
      research process. DISCUSSION: In-depth analysis of confidentiality, privacy and
      informed consent supports researchers in navigating these ethical issues in care 
      homes research. Placing the older person at the centre of ethical decisions
      enables the researcher to consider simultaneously the context and relationships
      that exist. This promotes a transparent process that demonstrates ethical
      sensitivity. CONCLUSION: When involved in ethical decisions in care homes,
      researchers are encouraged to consider how each participant may engage in a
      consultative process, acknowledging that they are a person living in a social
      world, interacting with both researcher and their environment. This approach
      promotes the inclusion of older people in decisions affecting the research
      process.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Wilson, Christine Brown
AU  - Wilson CB
AD  - Christine Brown Wilson PhD RN Lecturer in Continuing Care School of Nursing,
      Midwifery and Social Work, University of Manchester, UK.
      christine.brownwilson@manchester.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20110408
PL  - England
TA  - J Adv Nurs
JT  - Journal of advanced nursing
JID - 7609811
SB  - IM
MH  - Aged
MH  - Community Participation
MH  - Confidentiality/ethics
MH  - Disclosure/ethics
MH  - *Ethics, Research
MH  - Female
MH  - *Homes for the Aged
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Male
MH  - Nursing Methodology Research
MH  - Privacy
MH  - Qualitative Research
MH  - Research Subjects/psychology
MH  - Researcher-Subject Relations/ethics
MH  - United Kingdom
MH  - Vulnerable Populations
EDAT- 2011/04/12 06:00
MHDA- 2011/11/10 06:00
CRDT- 2011/04/12 06:00
PHST- 2011/04/12 06:00 [entrez]
PHST- 2011/04/12 06:00 [pubmed]
PHST- 2011/11/10 06:00 [medline]
AID - 10.1111/j.1365-2648.2011.05632.x [doi]
PST - ppublish
SO  - J Adv Nurs. 2011 Sep;67(9):2068-77. doi: 10.1111/j.1365-2648.2011.05632.x. Epub
      2011 Apr 8.


PMID- 21477104
OWN - NLM
STAT- MEDLINE
DCOM- 20111114
LR  - 20110712
IS  - 1600-9657 (Electronic)
IS  - 1600-4469 (Linking)
VI  - 27
IP  - 4
DP  - 2011 Aug
TI  - Critical considerations when planning experimental in vivo studies in dental
      traumatology.
PG  - 275-80
LID - 10.1111/j.1600-9657.2011.00983.x [doi]
AB  - In vivo studies are sometimes needed to understand healing processes after
      trauma. For several reasons, not the least ethical, such studies have to be
      carefully planned and important considerations have to be taken into account
      about suitability of the experimental model, sample size and optimizing the
      accuracy of the analysis. Several manuscripts of in vivo studies are submitted
      for publication to Dental Traumatology and rejected because of inadequate design,
      methodology or insufficient documentation of the results. The authors have
      substantial experience in experimental in vivo studies of tissue healing in
      dental traumatology and share their knowledge regarding critical considerations
      when planning experimental in vivo studies.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Andreasen, Jens O
AU  - Andreasen JO
AD  - Department of Oral and Maxillofacial Surgery, Resource Centre for Rare Oral
      Diseases, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark.
      jens.ove.andreasen@rh.regionh.dk
FAU - Andersson, Lars
AU  - Andersson L
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110407
PL  - Denmark
TA  - Dent Traumatol
JT  - Dental traumatology : official publication of International Association for
      Dental Traumatology
JID - 101091305
MH  - Animal Experimentation/*ethics/standards
MH  - Animals
MH  - Dental Pulp/injuries
MH  - *Models, Animal
MH  - Periodontal Ligament/injuries
MH  - *Research Design
MH  - Statistics as Topic
MH  - Tooth Injuries/*therapy
MH  - Traumatology/methods
MH  - *Wound Healing
EDAT- 2011/04/12 06:00
MHDA- 2011/11/15 06:00
CRDT- 2011/04/12 06:00
PHST- 2011/04/12 06:00 [entrez]
PHST- 2011/04/12 06:00 [pubmed]
PHST- 2011/11/15 06:00 [medline]
AID - 10.1111/j.1600-9657.2011.00983.x [doi]
PST - ppublish
SO  - Dent Traumatol. 2011 Aug;27(4):275-80. doi: 10.1111/j.1600-9657.2011.00983.x.
      Epub 2011 Apr 7.


PMID- 21476900
OWN - NLM
STAT- MEDLINE
DCOM- 20111123
LR  - 20110526
IS  - 1557-850X (Electronic)
IS  - 1538-7135 (Linking)
VI  - 9
IP  - 2
DP  - 2011 Jun
TI  - Challenges for mental health services raised by disaster preparedness: mapping
      the ethical and therapeutic terrain.
PG  - 175-9
LID - 10.1089/bsp.2010.0068 [doi]
AB  - Identifying vulnerable groups and ensuring that their needs are met during
      disasters--whether naturally occurring or manmade--are vital aspects of
      preparedness planning. Developing preparedness strategies that are responsive to 
      those at greatest risk is a moral mandate, justified by the principles of
      beneficence, justice, and respect for autonomy. Individuals with preexisting
      mental disorders and newly emergent psychological symptoms are particularly
      vulnerable to adverse outcomes during and after disasters. Without advance
      planning, these individuals might not benefit from necessary mental health
      services and treatments during and after disasters. In this commentary, we
      discuss ethical issues that arise in emergency preparedness planning for
      vulnerable individuals with psychological and psychiatric conditions and
      disorders.
FAU - Rabins, Peter V
AU  - Rabins PV
AD  - Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of
      Medicine, Baltimore, Maryland 21287-7279, USA. pvrabins@jhmi.edu
FAU - Kass, Nancy E
AU  - Kass NE
FAU - Rutkow, Lainie
AU  - Rutkow L
FAU - Vernick, Jon S
AU  - Vernick JS
FAU - Hodge, James G
AU  - Hodge JG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20110410
PL  - United States
TA  - Biosecur Bioterror
JT  - Biosecurity and bioterrorism : biodefense strategy, practice, and science
JID - 101156085
RN  - 0 (Psychotropic Drugs)
SB  - IM
MH  - Cognition Disorders/therapy
MH  - Continuity of Patient Care
MH  - Disaster Planning/*organization & administration
MH  - Humans
MH  - Mental Health Services/*ethics/*organization & administration
MH  - Psychotropic Drugs/supply & distribution
MH  - Stress Disorders, Traumatic, Acute/diagnosis/epidemiology/therapy
MH  - Substance-Related Disorders/therapy
EDAT- 2011/04/12 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/04/12 06:00
PHST- 2011/04/12 06:00 [entrez]
PHST- 2011/04/12 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1089/bsp.2010.0068 [doi]
PST - ppublish
SO  - Biosecur Bioterror. 2011 Jun;9(2):175-9. doi: 10.1089/bsp.2010.0068. Epub 2011
      Apr 10.


PMID- 21475333
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20181201
IS  - 1175-8716 (Electronic)
IS  - 0028-8446 (Linking)
VI  - 124
IP  - 1328
DP  - 2011 Jan 21
TI  - CPR for all? Ethical and medicolegal considerations.
PG  - 7-9
FAU - Freebairn, Ross
AU  - Freebairn R
LA  - eng
PT  - Editorial
PT  - Comment
DEP - 20110121
PL  - New Zealand
TA  - N Z Med J
JT  - The New Zealand medical journal
JID - 0401067
SB  - IM
CON - N Z Med J. 2011 Jan 21;124(1328):106-12. PMID: 21475345
MH  - *Cardiopulmonary Resuscitation/ethics/statistics & numerical data
MH  - Humans
MH  - *Liability, Legal
MH  - New Zealand
MH  - Resuscitation Orders/ethics/legislation & jurisprudence
EDAT- 2011/04/09 06:00
MHDA- 2011/06/29 06:00
CRDT- 2011/04/09 06:00
PHST- 2011/04/09 06:00 [entrez]
PHST- 2011/04/09 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
PST - epublish
SO  - N Z Med J. 2011 Jan 21;124(1328):7-9.


PMID- 21475314
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20220309
IS  - 1476-5454 (Electronic)
IS  - 0950-222X (Linking)
VI  - 25
IP  - 7
DP  - 2011 Jul
TI  - Prevalence of ocular motor cranial nerve palsy and associations following stroke.
PG  - 881-7
LID - 10.1038/eye.2011.78 [doi]
AB  - AIM: Occurrence of ocular motor cranial nerve palsies (OMCNP), following stroke, 
      has not been reported in relation to the type of OMCNP seen and in relation to
      brain area affected by stroke. The aim of this study was to identify all patients
      referred with suspected visual impairment to establish the presence and type of
      OMCNP. METHODS: Prospective, observation study with standardised referral and
      assessment forms across 20 sites. Visual assessment included visual acuity
      measurement, visual field assessment, ocular alignment, and movement and visual
      inattention assessment. Multicentre ethics approval and informed patient consent 
      was obtained. RESULTS: In total, 915 patients were recruited with mean age of
      69.18 years (SD 14.19). Altogether, 498 patients (54%) were diagnosed with ocular
      motility abnormalities. Of these, 89 patients (18%) had OMCNP. Unilateral third
      nerve palsy was present in 23 patients (26%), fourth nerve palsy in 14 patients
      (16%), and sixth nerve palsy in 52 patients (58%). Out of these, 44 patients had 
      isolated OMCNP and 45 had OMCNP combined with other ocular motility
      abnormalities. Location of stroke was reported mainly in cerebellum, brain stem, 
      thalamus, and internal and external capsules. Treatment was provided for each
      case including prisms, occlusion, typoscope, scanning exercises, and refraction. 
      CONCLUSIONS: OMCNP account for 18% of eye movement abnormalities in this stroke
      sub-population. Sixth CNP was most common, followed by third and fourth CNP. Half
      were isolated and half combined with other eye movement abnormality. Most were
      treated with prisms or occlusion. The reported brain area affected by stroke was 
      typically the cerebellum, brain stem, and diencephalic structures.
FAU - Rowe, F
AU  - Rowe F
AD  - Directorate of Orthoptics and Vision Science, University of Liverpool, Liverpool,
      UK. rowef@liverpool.ac.uk
CN  - VIS group UK
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20110408
PL  - England
TA  - Eye (Lond)
JT  - Eye (London, England)
JID - 8703986
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Middle Aged
MH  - Ocular Motility Disorders/*epidemiology/etiology
MH  - Prevalence
MH  - Prospective Studies
MH  - Stroke/*complications/physiopathology
MH  - United Kingdom/epidemiology
MH  - Vision Disorders/epidemiology
MH  - Visual Perception/physiology
MH  - Young Adult
PMC - PMC3178159
IR  - Wright D
FIR - Wright, David
IR  - Brand D
FIR - Brand, Darren
IR  - Jackson C
FIR - Jackson, Carole
IR  - Harrison S
FIR - Harrison, Shirley
IR  - Eccleston C
FIR - Eccleston, Carla
IR  - Maan T
FIR - Maan, Tallat
IR  - Scott C
FIR - Scott, Claire
IR  - Vogwell L
FIR - Vogwell, Linda
IR  - Peel S
FIR - Peel, Sarah
IR  - Robson L
FIR - Robson, Leonie
IR  - Akerman N
FIR - Akerman, Nicola
IR  - Dodridge C
FIR - Dodridge, Caroline
IR  - Howard C
FIR - Howard, Claire
IR  - Shipman T
FIR - Shipman, Tracey
IR  - Sperring U
FIR - Sperring, Una
IR  - Yarde S
FIR - Yarde, Sue
IR  - Rowe F
FIR - Rowe, Fiona
IR  - MacDiarmid S
FIR - MacDiarmid, Sonia
IR  - Freeman C
FIR - Freeman, Cicely
EDAT- 2011/04/09 06:00
MHDA- 2011/11/09 06:00
CRDT- 2011/04/09 06:00
PHST- 2011/04/09 06:00 [entrez]
PHST- 2011/04/09 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - eye201178 [pii]
AID - 10.1038/eye.2011.78 [doi]
PST - ppublish
SO  - Eye (Lond). 2011 Jul;25(7):881-7. doi: 10.1038/eye.2011.78. Epub 2011 Apr 8.


PMID- 21475273
OWN - NLM
STAT- MEDLINE
DCOM- 20110922
LR  - 20161125
IS  - 1476-5373 (Electronic)
IS  - 0007-0610 (Linking)
VI  - 210
IP  - 7
DP  - 2011 Apr 9
TI  - Homeopathy and its ethical use in dentistry.
PG  - 299-301
LID - 10.1038/sj.bdj.2011.237 [doi]
AB  - Media coverage of homeopathy over the past few years has tended to concentrate on
      the very negative position taken by sceptics, while the possible benefits of
      homeopathy are ignored. This has resulted in coverage that has been rather
      one-sided, inaccurate and at times hysterical. A perfect example is Dr David
      Shaw's opinion piece 'Unethical aspects of homeopathic dentistry' (Br Dent J
      2010; 209: 493-496) which falls far short of providing a basis for balanced
      intellectual discussion. The authors are therefore grateful to the BDJ for the
      opportunity to outline the case for integrating homeopathy in dental practice.
FAU - Eames, S
AU  - Eames S
AD  - Faculty of Homeopathy, Hahnemann House, 29 Park Street West, Luton, LU1 3BE.
FAU - Darby, P
AU  - Darby P
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br Dent J
JT  - British dental journal
JID - 7513219
SB  - IM
CIN - Br Dent J. 2011 Jun;210(12):557. PMID: 21701451
CIN - Br Dent J. 2011 Jun;210(12):558. PMID: 21701453
CIN - Br Dent J. 2011 Jun;210(12):558. PMID: 21701454
MH  - *Dentistry
MH  - Ethics, Dental
MH  - Homeopathy/ethics/*methods/standards
MH  - Humans
MH  - Licensure
MH  - Meta-Analysis as Topic
MH  - Mouth Diseases/drug therapy
MH  - Placebo Effect
MH  - Randomized Controlled Trials as Topic
MH  - Registries
MH  - Science
MH  - Societies, Scientific
MH  - Treatment Outcome
MH  - United Kingdom
EDAT- 2011/04/09 06:00
MHDA- 2011/09/23 06:00
CRDT- 2011/04/09 06:00
PHST- 2011/02/22 00:00 [accepted]
PHST- 2011/04/09 06:00 [entrez]
PHST- 2011/04/09 06:00 [pubmed]
PHST- 2011/09/23 06:00 [medline]
AID - sj.bdj.2011.237 [pii]
AID - 10.1038/sj.bdj.2011.237 [doi]
PST - ppublish
SO  - Br Dent J. 2011 Apr 9;210(7):299-301. doi: 10.1038/sj.bdj.2011.237.


PMID- 21475100
OWN - NLM
STAT- MEDLINE
DCOM- 20110519
LR  - 20191112
IS  - 1750-8460 (Print)
IS  - 1750-8460 (Linking)
VI  - 72
IP  - 3
DP  - 2011 Mar
TI  - Self harm on prescription: the lesser of two evils?
PG  - 172-3
AB  - This article reports an innovative method of using a diabetic lancet pen to
      reduce complex self-injurious behaviour and discuss the ethical considerations.
FAU - Durrani, Amanullah
AU  - Durrani A
AD  - South Staffordshire and Shropshire Mental Health NHS Foundation Trust, Shelton
      Hospital, Bicton Heath, Shrewsbury SY3 8DN.
FAU - Deahl, Martin
AU  - Deahl M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Br J Hosp Med (Lond)
JT  - British journal of hospital medicine (London, England : 2005)
JID - 101257109
SB  - IM
MH  - Adult
MH  - Drug Overdose
MH  - Female
MH  - Hospitalization
MH  - Humans
MH  - Prescriptions
MH  - Self-Injurious Behavior/*prevention & control/psychology
MH  - *Surgical Instruments
MH  - Treatment Outcome
EDAT- 2011/04/09 06:00
MHDA- 2011/05/20 06:00
CRDT- 2011/04/09 06:00
PHST- 2011/04/09 06:00 [entrez]
PHST- 2011/04/09 06:00 [pubmed]
PHST- 2011/05/20 06:00 [medline]
AID - 10.12968/hmed.2011.72.3.172 [doi]
PST - ppublish
SO  - Br J Hosp Med (Lond). 2011 Mar;72(3):172-3. doi: 10.12968/hmed.2011.72.3.172.


PMID- 21475053
OWN - NLM
STAT- MEDLINE
DCOM- 20110805
LR  - 20110825
IS  - 1932-8095 (Electronic)
IS  - 1932-8087 (Linking)
VI  - 16
IP  - 3
DP  - 2011 May-Jun
TI  - Introducing HCM v3.0: a standard model for hospital case management practice.
PG  - 109-25; quiz 126-7
LID - 10.1097/NCM.0b013e318212b5c1 [doi]
AB  - PURPOSE/OBJECTIVES: Like the professional definitions of case management, the
      practice of hospital management is a dynamic process. However, because hospital
      case management programs come in so many shapes and sizes, there is a widespread 
      tendency to forego the process and instead focus on the static tasks associated
      with utilization review and discharge plan arrangements. As a result, the
      research identifying best practices is inhibited and hospital case management
      practice is constrained. This article speaks to the need for a standard approach 
      to hospital case management and offers a model that positions the hospital case
      manager as the primary patient advocate and physician partner that are among the 
      essential ingredients for successful participation in accountable care
      organizations, progression-of-care management, and transitions of care support.
      PRIMARY PRACTICE SETTING: Acute care hospitals, integrated delivery systems.
      IMPLICATIONS FOR CASE MANAGEMENT PRACTICE: 1. Hospital case managers must
      practice in accordance with the professional process of case management. 2.
      Hospital case management programs must be structured in such a way as to support 
      the professional process of case management. 3. The roles and responsibilities of
      hospital case managers must be unmistakably defined to make certain that
      proactive advocacy is visible as the essential ethical obligation.
FAU - Daniels, Stefani
AU  - Daniels S
AD  - Phoenix: The Hospital Case Management Company, 1401 South Ocean Boulevard,
      Pompano Beach, FL 33062, USA. daniels@phoenixmed.net
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Prof Case Manag
JT  - Professional case management
JID - 101291585
MH  - *Continuity of Patient Care
MH  - Decision Making
MH  - Evidence-Based Practice/methods/standards
MH  - Hospitals/*standards
MH  - Humans
MH  - Models, Organizational
MH  - Organizational Culture
MH  - Patient Advocacy
MH  - *Patient Discharge
MH  - United States
EDAT- 2011/04/09 06:00
MHDA- 2011/08/06 06:00
CRDT- 2011/04/09 06:00
PHST- 2011/04/09 06:00 [entrez]
PHST- 2011/04/09 06:00 [pubmed]
PHST- 2011/08/06 06:00 [medline]
AID - 10.1097/NCM.0b013e318212b5c1 [doi]
AID - 01269241-201105000-00004 [pii]
PST - ppublish
SO  - Prof Case Manag. 2011 May-Jun;16(3):109-25; quiz 126-7. doi:
      10.1097/NCM.0b013e318212b5c1.


PMID- 21474707
OWN - NLM
STAT- MEDLINE
DCOM- 20110902
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 260
IP  - 1
DP  - 2011 Jul
TI  - Hemorrhagic shock in polytrauma patients: early detection with renal Doppler
      resistive index measurements.
PG  - 112-8
LID - 10.1148/radiol.11102338 [doi]
AB  - PURPOSE: To investigate whether renal Doppler resistive index (RI) changes occur 
      early during posttraumatic bleeding and may be predictive of occult
      hypoperfusion-and thus hemorrhagic shock-in patients with polytrauma. MATERIALS
      AND METHODS: This study was approved by the institutional ethics committee, and
      informed consent was obtained from all patients. The renal Doppler RI was
      measured in 52 hemodynamically stable adult patients admitted to the emergency
      department (ED) because of polytrauma. Renal Doppler RI, hemoglobin, standard
      base excess, lactate, systolic blood pressure, pH, heart rate, and inferior vena 
      cava diameter values were recorded at admittance and correlated with outcome
      (progression or nonprogression to hemorrhagic shock). Logistic regression
      analysis was performed to assess the risk factors for progression to hemorrhagic 
      shock. RESULTS: Twenty-nine patients developed hemorrhagic shock, and 23 did not.
      At univariable analysis, the hemorrhagic shock group, as compared with the
      nonhemorrhagic shock group, had higher renal Doppler RI (mean, 0.80 +/- 0.10
      [standard deviation] vs 0.63 +/- 0.03; P < .01), injury severity score (mean, 36 
      +/- 11 vs 26 +/- 5; P < .01), and standard base excess (mean, -4.0 mEq/L +/- 4 vs
      1 mEq/L +/- 3; P = .04) values. At logistic regression analysis, a renal Doppler 
      RI greater than 0.7 (vs less than or equal to 0.7) was the only independent risk 
      factor for progression to hemorrhagic shock (odds ratio, 57.8; 95% confidence
      interval: 10.5, 317.0) (P < .001). CONCLUSION: In polytrauma patients who are
      hemodynamically stable at admittance to the ED, renal cortical blood flow
      redistribution occurs very early in response to occult bleeding and might be
      noninvasively detected by using the renal Doppler RI. A renal Doppler RI greater 
      than 0.7 is predictive of progression to hemorrhagic shock in polytrauma
      patients.
FAU - Corradi, Francesco
AU  - Corradi F
AD  - Dipartimento di Scienze Chirurgiche e Diangostiche Integrate, Universita degli
      Studi di Genova, Largo Rosanna Benzi 8, 16132 Genova, Italy.
      francescorradi@gmail.com
FAU - Brusasco, Claudia
AU  - Brusasco C
FAU - Vezzani, Antonella
AU  - Vezzani A
FAU - Palermo, Salvatore
AU  - Palermo S
FAU - Altomonte, Fiorella
AU  - Altomonte F
FAU - Moscatelli, Paolo
AU  - Moscatelli P
FAU - Pelosi, Paolo
AU  - Pelosi P
LA  - eng
PT  - Journal Article
DEP - 20110407
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Early Diagnosis
MH  - Female
MH  - Humans
MH  - Kidney/*diagnostic imaging/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Multiple Trauma/complications/*diagnostic imaging/*physiopathology
MH  - Renal Circulation
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Shock, Hemorrhagic/*diagnostic imaging/etiology/*physiopathology
MH  - Ultrasonography, Doppler/*methods
MH  - Vascular Resistance
MH  - Young Adult
EDAT- 2011/04/09 06:00
MHDA- 2011/09/03 06:00
CRDT- 2011/04/09 06:00
PHST- 2011/04/09 06:00 [entrez]
PHST- 2011/04/09 06:00 [pubmed]
PHST- 2011/09/03 06:00 [medline]
AID - radiol.11102338 [pii]
AID - 10.1148/radiol.11102338 [doi]
PST - ppublish
SO  - Radiology. 2011 Jul;260(1):112-8. doi: 10.1148/radiol.11102338. Epub 2011 Apr 7.


PMID- 21474704
OWN - NLM
STAT- MEDLINE
DCOM- 20110902
LR  - 20220318
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 260
IP  - 1
DP  - 2011 Jul
TI  - Microstructural brain abnormalities in patients with obsessive-compulsive
      disorder: diffusion-tensor MR imaging study at 3.0 T.
PG  - 216-23
LID - 10.1148/radiol.11101971 [doi]
AB  - PURPOSE: To use diffusion-tensor (DT) magnetic resonance (MR) imaging to explore 
      the integrity and connectivity of brain white matter in patients with
      obsessive-compulsive disorder (OCD) and to correlate DT parameters with clinical 
      measures. MATERIALS AND METHODS: This study was approved by the local ethical
      committee, and written informed consent was obtained from all participants. DT
      imaging was performed by using a 3.0-T MR imager in 23 patients with OCD and 23
      healthy control subjects matched for age, sex, education level, and handedness.
      By using voxel-based analysis, fractional anisotropy (FA) and axial and radial
      diffusivities were compared between patients and control subjects with a
      two-sample t test and were tested for correlation with symptom severity, as
      measured by using the Yale-Brown Obsessive-Compulsive Scale and
      obsessive-compulsive subscale scores, and with illness duration, as measured by
      using simple regression in statistical parametric mapping program. RESULTS:
      Compared with control subjects, OCD patients demonstrated significantly increased
      FA in the genu and body of corpus callosum and white matter of right superior
      frontal gyrus and corpus callosum; no areas of significantly decreased FA were
      found. For areas of increased FA, axial diffusivity was higher than that in
      control subjects, while radial diffusivity was not significantly different. The
      FA values in the white matter of left middle temporal gyrus in OCD patients
      correlated positively with clinical measures (r = 0.542, P < .001). CONCLUSION:
      OCD is associated with axonal microstructural abnormalities within the white
      matter, which may indicate impaired axonal integrity and increased connectivity. 
      The positive correlation between DT abnormalities and symptom severity suggests
      that DT imaging may be of clinical value in measuring and following disability in
      OCD patients.
FAU - Li, Fei
AU  - Li F
AD  - Department of Radiology, Huaxi MR Research Center, West China Hospital of Sichuan
      University, 37 Guo Xuexiang, Chengdu, Sichuan 610041, China.
FAU - Huang, Xiaoqi
AU  - Huang X
FAU - Yang, Yanchun
AU  - Yang Y
FAU - Li, Bin
AU  - Li B
FAU - Wu, Qizhu
AU  - Wu Q
FAU - Zhang, Tijiang
AU  - Zhang T
FAU - Lui, Su
AU  - Lui S
FAU - Kemp, Graham J
AU  - Kemp GJ
FAU - Gong, Qiyong
AU  - Gong Q
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110407
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adult
MH  - Brain/*pathology
MH  - Brain Diseases/*complications/*pathology
MH  - Diffusion Magnetic Resonance Imaging/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Obsessive-Compulsive Disorder/*complications/*pathology
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
EDAT- 2011/04/09 06:00
MHDA- 2011/09/03 06:00
CRDT- 2011/04/09 06:00
PHST- 2011/04/09 06:00 [entrez]
PHST- 2011/04/09 06:00 [pubmed]
PHST- 2011/09/03 06:00 [medline]
AID - radiol.11101971 [pii]
AID - 10.1148/radiol.11101971 [doi]
PST - ppublish
SO  - Radiology. 2011 Jul;260(1):216-23. doi: 10.1148/radiol.11101971. Epub 2011 Apr 7.


PMID- 21474573
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20170528
IS  - 1931-3543 (Electronic)
IS  - 0012-3692 (Linking)
VI  - 140
IP  - 4
DP  - 2011 Oct
TI  - Measurement of right and left ventricular function by ECG-synchronized CT
      scanning in patients with acute pulmonary embolism: usefulness for predicting
      short-term outcome.
PG  - 1008-1015
LID - S0012-3692(11)60538-2 [pii]
LID - 10.1378/chest.10-3174 [doi]
AB  - BACKGROUND: Right ventricular (RV) function is predictive of outcome in patients 
      with acute pulmonary embolism (PE). We assessed the possible incremental value of
      ventricular function with ECG-synchronized cardiac CT scanning over pulmonary CT 
      scan angiography (CTA) for predicting short-term outcome in patients with
      suspected acute PE. METHODS: The local ethics committee approved the study, and
      informed consent was obtained. In addition to standard CTA, 430 consecutive
      patients (193 men, 237 women; age, 55 +/- 17 years) with suspected acute PE
      underwent ECG-synchronized CT scanning to assess ventricular function. RV/left
      ventricular (LV) function ratio and pulmonary obstruction index were obtained
      from non-ECG-synchronized CTA. Ventricular function was used to predict adverse
      events (< 6 weeks). Receiver operating characteristic analysis was performed to
      determine differences between ECG-synchronized CT scan and CTA in predicting
      outcome. RESULTS: In 113 patients with PE, RV and LV ejection fraction (EF) and
      RV/LV diameter and volume ratios were associated with adverse outcome (P < .05), 
      whereas vascular obstruction index was not. RVEF had the largest area under the
      receiver operating characteristic curve (0.75; 95% CI, 0.62-0.88) for predicting 
      adverse outcome but had no significant incremental value over the RV/LV function 
      ratio (0.72; 95% CI, 0.57-0.86; P = .25). All parameters revealed high negative
      predictive values (94%-98%) but low positive predictive values (13%-18%). For
      disease-specific outcome, areas under the curve were 0.80 (95% CI, 0.69-0.91) for
      RVEF vs 0.68 (95% CI, 0.48-0.88) for axial RV/LV ratio; the difference was not
      significant (P = .07). RVEF and RV/LV ratio proved better predictors for outcome 
      than pulmonary obstruction index (both P < .001). CONCLUSIONS: RVEF was the best 
      predictor for clinical outcome in patients with acute PE. However, incremental
      value of RVEF over axial RV/LV ratio was not found.
FAU - van der Bijl, Noortje
AU  - van der Bijl N
AD  - Department of Radiology, Leiden University Medical Center, Leiden, The
      Netherlands.
FAU - Klok, Frederikus A
AU  - Klok FA
AD  - Section of Vascular Medicine, Department of General Internal
      Medicine-Endocrinology, Leiden University Medical Center, Leiden, The
      Netherlands.
FAU - Huisman, Menno V
AU  - Huisman MV
AD  - Section of Vascular Medicine, Department of General Internal
      Medicine-Endocrinology, Leiden University Medical Center, Leiden, The
      Netherlands.
FAU - van Rooden, Jan-Kees
AU  - van Rooden JK
AD  - Department of Radiology, Haga Teaching Hospital, Den Haag, The Netherlands.
FAU - Mertens, Bart J A
AU  - Mertens BJA
AD  - Department of Medical Statistics and Bioinformatics, Leiden University Medical
      Center, Leiden, The Netherlands.
FAU - de Roos, Albert
AU  - de Roos A
AD  - Department of Radiology, Leiden University Medical Center, Leiden, The
      Netherlands.
FAU - Kroft, Lucia J M
AU  - Kroft LJM
AD  - Department of Radiology, Leiden University Medical Center, Leiden, The
      Netherlands. Electronic address: l.j.m.kroft@lumc.nl.
LA  - eng
PT  - Journal Article
DEP - 20110407
PL  - United States
TA  - Chest
JT  - Chest
JID - 0231335
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Aged
MH  - Cohort Studies
MH  - *Electrocardiography
MH  - Female
MH  - Follow-Up Studies
MH  - Heart/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Prospective Studies
MH  - Pulmonary Embolism/*diagnosis/diagnostic imaging/*physiopathology
MH  - ROC Curve
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - Stroke Volume/physiology
MH  - *Tomography, X-Ray Computed
MH  - Ventricular Dysfunction, Left/diagnostic imaging/*physiopathology
MH  - Ventricular Dysfunction, Right/diagnostic imaging/*physiopathology
EDAT- 2011/04/09 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/04/09 06:00
PHST- 2011/04/09 06:00 [entrez]
PHST- 2011/04/09 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0012-3692(11)60538-2 [pii]
AID - 10.1378/chest.10-3174 [doi]
PST - ppublish
SO  - Chest. 2011 Oct;140(4):1008-1015. doi: 10.1378/chest.10-3174. Epub 2011 Apr 7.


PMID- 21474230
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20191210
IS  - 1579-2242 (Electronic)
IS  - 0300-8932 (Linking)
VI  - 64
IP  - 5
DP  - 2011 May
TI  - [Ethical considerations in the publication of scientific articles].
PG  - 427-9
LID - 10.1016/j.recesp.2011.02.006 [doi]
FAU - Avanzas, Pablo
AU  - Avanzas P
FAU - Bayes-Genis, Antoni
AU  - Bayes-Genis A
FAU - Perez de Isla, Leopoldo
AU  - Perez de Isla L
FAU - Sanchis, Juan
AU  - Sanchis J
FAU - Heras, Magda
AU  - Heras M
LA  - spa
PT  - Editorial
TT  - Consideraciones eticas de la publicacion de articulos cientificos.
DEP - 20110406
PL  - Spain
TA  - Rev Esp Cardiol
JT  - Revista espanola de cardiologia
JID - 0404277
SB  - IM
MH  - Authorship
MH  - Conflict of Interest
MH  - Duplicate Publications as Topic
MH  - *Ethics, Research
MH  - Publishing/*ethics
MH  - Scientific Misconduct
EDAT- 2011/04/09 06:00
MHDA- 2013/03/13 06:00
CRDT- 2011/04/09 06:00
PHST- 2011/02/03 00:00 [received]
PHST- 2011/02/03 00:00 [accepted]
PHST- 2011/04/09 06:00 [entrez]
PHST- 2011/04/09 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
AID - S0300-8932(11)00273-9 [pii]
AID - 10.1016/j.recesp.2011.02.006 [doi]
PST - ppublish
SO  - Rev Esp Cardiol. 2011 May;64(5):427-9. doi: 10.1016/j.recesp.2011.02.006. Epub
      2011 Apr 6.


PMID- 21474099
OWN - NLM
STAT- MEDLINE
DCOM- 20110729
LR  - 20160518
IS  - 1875-9777 (Electronic)
IS  - 1875-9777 (Linking)
VI  - 8
IP  - 4
DP  - 2011 Apr 8
TI  - Donation of embryos for human development and stem cell research.
PG  - 360-2
LID - 10.1016/j.stem.2011.02.018 [doi]
AB  - Using donated human embryos for scientific research raises ethical questions
      about the donation process. We describe a two-stage consent process designed to
      help couples make informed decisions about embryo disposition. This consent
      methodology minimizes conflict of interest, respects patient choice, and provides
      a much-needed resource to patients and the research community.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Kalista, Tasha
AU  - Kalista T
AD  - Institute for Stem Cell Biology and Regenerative Medicine, Stanford University,
      Stanford, CA 94305, USA.
FAU - Freeman, H Austinn
AU  - Freeman HA
FAU - Behr, Barry
AU  - Behr B
FAU - Pera, Renee Reijo
AU  - Pera RR
FAU - Scott, Christopher Thomas
AU  - Scott CT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell Stem Cell
JT  - Cell stem cell
JID - 101311472
SB  - IM
MH  - *Embryo Disposition/ethics
MH  - Embryo Research/ethics
MH  - Humans
MH  - Informed Consent
MH  - Methods
MH  - *Stem Cell Research/ethics
EDAT- 2011/04/09 06:00
MHDA- 2011/07/30 06:00
CRDT- 2011/04/09 06:00
PHST- 2011/04/09 06:00 [entrez]
PHST- 2011/04/09 06:00 [pubmed]
PHST- 2011/07/30 06:00 [medline]
AID - S1934-5909(11)00104-4 [pii]
AID - 10.1016/j.stem.2011.02.018 [doi]
PST - ppublish
SO  - Cell Stem Cell. 2011 Apr 8;8(4):360-2. doi: 10.1016/j.stem.2011.02.018.


PMID- 21473728
OWN - NLM
STAT- MEDLINE
DCOM- 20110830
LR  - 20151119
IS  - 1752-0371 (Electronic)
IS  - 1752-0363 (Linking)
VI  - 5
IP  - 2
DP  - 2011 Apr
TI  - Analysis of protein biomarkers in human clinical tumor samples: critical aspects 
      to success from tissue acquisition to analysis.
PG  - 227-48
LID - 10.2217/bmm.11.9 [doi]
AB  - There has been increased interest in the analysis of protein biomarkers in
      clinical tumor tissues in recent years. Tissue-based biomarker assays can add
      value and aid decision-making at all stages of drug development, as well as being
      developed for use as predictive biomarkers and for patient stratification and
      prognostication in the clinic. However, there must be an awareness of the legal
      and ethical issues related to the sourcing of human tissue samples. This article 
      also discusses the limits of scope and critical aspects on the successful use of 
      the following tissue-based methods: immunohistochemistry, tissue microarrays and 
      automated image analysis. Future advances in standardization of tissue biobanking
      methods, immunohistochemistry and quantitative image analysis techniques are also
      discussed.
FAU - Warren, Madhuri V
AU  - Warren MV
AD  - Pathology Diagnostics Ltd, St John's Innovation Centre, Cowley Road, Cambridge,
      CB4 0WS, UK. mvw@pathologydiagnostics.com
FAU - Chan, W Y Iris
AU  - Chan WY
FAU - Ridley, John M
AU  - Ridley JM
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Biomark Med
JT  - Biomarkers in medicine
JID - 101312535
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Neoplasm Proteins)
SB  - IM
MH  - Automation
MH  - Biomarkers, Tumor/*analysis
MH  - Clinical Trials as Topic
MH  - Diagnostic Imaging
MH  - European Union
MH  - Humans
MH  - Immunohistochemistry
MH  - Neoplasm Proteins/*analysis
MH  - Organ Preservation
MH  - Tissue Array Analysis
MH  - Tissue and Organ Harvesting/ethics/legislation & jurisprudence/*methods
MH  - United States
EDAT- 2011/04/09 06:00
MHDA- 2011/08/31 06:00
CRDT- 2011/04/09 06:00
PHST- 2011/04/09 06:00 [entrez]
PHST- 2011/04/09 06:00 [pubmed]
PHST- 2011/08/31 06:00 [medline]
AID - 10.2217/bmm.11.9 [doi]
PST - ppublish
SO  - Biomark Med. 2011 Apr;5(2):227-48. doi: 10.2217/bmm.11.9.


PMID- 21473562
OWN - NLM
STAT- MEDLINE
DCOM- 20110526
LR  - 20190923
IS  - 0278-4807 (Print)
IS  - 0278-4807 (Linking)
VI  - 36
IP  - 2
DP  - 2011 Mar-Apr
TI  - Ethical perspectives on self-neglect among older adults.
PG  - 60-5
AB  - Self-neglect is a serious and growing problem among older adults. A 2004 survey
      from Adult Protective Services (APS) showed that adults age 60 or older were
      named in 85,000 reports of self-neglect from 21 states (Naik, Lai, Kunik, & Dyer,
      2008; Teaster, Dugar, Mendiondo, Abner, & Cecil, 2006). Although rehabilitation
      nurses are obligated to uphold the autonomy of older adults and strengthen their 
      independence, dilemmas result when people's poor health behaviors put them or
      others at risk for negative consequences. When making decisions about nursing
      actions related to self-neglecting elderly people, the basic principles of
      autonomy, beneficence, nonmaleficence, and capacity must be considered. The
      purpose of this article is to discuss major ethical perspectives related to
      self-neglect among older adults.
FAU - Mauk, Kristen L
AU  - Mauk KL
AD  - Valparaiso University, Valparaiso, IN, USA. kris.mauk@valpo.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Rehabil Nurs
JT  - Rehabilitation nursing : the official journal of the Association of
      Rehabilitation Nurses
JID - 8104825
MH  - Aged
MH  - Elder Abuse/*ethics
MH  - Humans
MH  - Independent Living/*ethics
MH  - Rehabilitation Nursing/*ethics
MH  - Self Care/*ethics
EDAT- 2011/04/09 06:00
MHDA- 2011/05/27 06:00
CRDT- 2011/04/09 06:00
PHST- 2011/04/09 06:00 [entrez]
PHST- 2011/04/09 06:00 [pubmed]
PHST- 2011/05/27 06:00 [medline]
AID - 10.1002/j.2048-7940.2011.tb00067.x [doi]
PST - ppublish
SO  - Rehabil Nurs. 2011 Mar-Apr;36(2):60-5. doi: 10.1002/j.2048-7940.2011.tb00067.x.


PMID- 21473313
OWN - NLM
STAT- MEDLINE
DCOM- 20110524
LR  - 20220409
IS  - 0954-7762 (Print)
IS  - 0954-7762 (Linking)
VI  - 107
IP  - 5
DP  - 2011 Feb 8-14
TI  - How do nurses cope when values and practice conflict?
PG  - 20-3
AB  - BACKGROUND: A lack of opportunity to express values in nursing practice and a
      conflict of ideals with organisational constraints are associated with low job
      satisfaction and high attrition rates. AIM: To explore the stories of mental
      health nurses to find how values influence their experience of nursing practice. 
      METHOD: Twelve participants, who had between six months', and three years'
      experience of post-registration practice, were interviewed. RESULTS: Nurses'
      values were often established before they started training. Participants
      described values that were consistent with a commitment to person-centred care
      and professional and ethical principles expected by governing bodies. CONCLUSION:
      Mental health nurses are aware of the dissonance that arises when there is a
      conflict between their values and their practice. They respond to this in a
      variety of ways, notably through acceptance, rejection or innovation.
FAU - Stacey, Gemma
AU  - Stacey G
AD  - Division of Nursing, University of Nottingham.
FAU - Johnston, Kirsty
AU  - Johnston K
FAU - Stickley, Theo
AU  - Stickley T
FAU - Diamond, Bob
AU  - Diamond B
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Times
JT  - Nursing times
JID - 0423236
MH  - *Adaptation, Psychological
MH  - Burnout, Professional/*psychology
MH  - Ethics, Nursing
MH  - Humans
MH  - Nursing Methodology Research
MH  - Professional Practice/*ethics
MH  - Psychiatric Nursing/*ethics
MH  - *Social Values
EDAT- 2011/04/09 06:00
MHDA- 2011/05/25 06:00
CRDT- 2011/04/09 06:00
PHST- 2011/04/09 06:00 [entrez]
PHST- 2011/04/09 06:00 [pubmed]
PHST- 2011/05/25 06:00 [medline]
PST - ppublish
SO  - Nurs Times. 2011 Feb 8-14;107(5):20-3.


PMID- 21473225
OWN - NLM
STAT- MEDLINE
DCOM- 20110524
LR  - 20220409
IS  - 0094-6354 (Print)
IS  - 0094-6354 (Linking)
VI  - 79
IP  - 1
DP  - 2011 Feb
TI  - Moral distress in certified registered nurse anesthetists: implications for
      nursing practice.
PG  - 39-45
AB  - Registered nurses are frequently confronted with ethical dilemmas in their
      nursing practice. As a consequence of their decisions regarding ethical
      challenges, nurses report experiencing moral distress. This experience is often
      manifested by such feelings as anger, guilt, and sadness, and has been identified
      as a contributing factor to burnout and turnover in nursing. The purpose of this 
      exploratory, descriptive study was to determine if Certified Registered Nurse
      Anesthetists (CRNAs) experience moral distress in their nursing practice. A
      random sample of 800 CRNAs from the registry of the American Association of Nurse
      Anesthetists was selected to participate in this study. Participating nurses were
      asked to complete a demographic data survey and the Ethics Stress Scale. Three
      hundred surveys were analyzed for this study. The data supported the assumption
      that CRNAs do experience moral distress in their nursing practice. Although a
      small number of nurse anesthetists experienced high levels of moral distress,
      CRNAs generally experienced moderate levels of moral distress. Moral distress was
      associated with situations in which anesthetists believed they were aware of the 
      morally correct course of action but were unable to follow through with these
      behaviors. Also, CRNAs reported physical and psychological manifestations in
      relation to moral distress.
FAU - Radzvin, Linda Clerici
AU  - Radzvin LC
AD  - Community College of Allegheny County, Boyce Campus, Monroeville, Pennsylvania,
      USA. lradzvin@ccac.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - AANA J
JT  - AANA journal
JID - 0431420
MH  - *Affective Symptoms
MH  - Burnout, Professional/epidemiology/*psychology
MH  - Data Collection
MH  - Female
MH  - Humans
MH  - Male
MH  - Nurse Anesthetists/*ethics/*psychology/statistics & numerical data
MH  - Professional Practice/*ethics/statistics & numerical data
EDAT- 2011/04/09 06:00
MHDA- 2011/05/25 06:00
CRDT- 2011/04/09 06:00
PHST- 2011/04/09 06:00 [entrez]
PHST- 2011/04/09 06:00 [pubmed]
PHST- 2011/05/25 06:00 [medline]
PST - ppublish
SO  - AANA J. 2011 Feb;79(1):39-45.


PMID- 21473188
OWN - NLM
STAT- MEDLINE
DCOM- 20110524
LR  - 20190923
IS  - 0743-2550 (Print)
IS  - 0743-2550 (Linking)
VI  - 28
IP  - 2
DP  - 2011 Apr-Jun
TI  - Ethics and empathy (part two).
PG  - 74
FAU - Salladay, Susan A
AU  - Salladay SA
AD  - Cedarville University, Ohio, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Christ Nurs
JT  - Journal of Christian nursing : a quarterly publication of Nurses Christian
      Fellowship
JID - 8411743
MH  - *Altruism
MH  - *Christianity
MH  - *Empathy
MH  - *Ethics, Nursing
MH  - Humans
EDAT- 2011/04/09 06:00
MHDA- 2011/05/25 06:00
CRDT- 2011/04/09 06:00
PHST- 2011/04/09 06:00 [entrez]
PHST- 2011/04/09 06:00 [pubmed]
PHST- 2011/05/25 06:00 [medline]
AID - 10.1097/cnj.0b013e31820ca835 [doi]
PST - ppublish
SO  - J Christ Nurs. 2011 Apr-Jun;28(2):74. doi: 10.1097/cnj.0b013e31820ca835.


PMID- 21473168
OWN - HMD
STAT- MEDLINE
DCOM- 20110623
LR  - 20191112
IS  - 1460-8235 (Print)
IS  - 1460-8235 (Linking)
VI  - 13
IP  - 1
DP  - 2011
TI  - Eternal hate and conscience: on the filiation between Freudian psychoanalysis and
      sixteenth and early seventeenth century Protestant thought.
PG  - 5-24
AB  - In his seminar on ethics Jacques Lacan suggests there exists a "filiation or
      cultural paternity" between Freudian psychoanalysis and a "new direction of
      thought" that starts with Luther's conceptualization of God's eternal hate of
      man, and is then futher continued in Calvinism. In this article this thesis is
      explored. The author argues that there is not only a familiarity between the
      Protestant doctrines of predestination and Freud's reconstruction of prehistoric 
      events and primal scenes, but also that Lacan's views on conscience formation and
      his elaborations of the complexity of moral decisions resembles Calvinist thought
      on civil and spiritual conscience, and the longing for restoration of a lost
      image of God.
FAU - Westerink, Herman
AU  - Westerink H
AD  - University of Vienna, Austria.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - England
TA  - Psychoanal Hist
JT  - Psychoanalysis and history
JID - 100887289
MH  - *Conscience
MH  - *Ethics/history
MH  - *Freudian Theory/history
MH  - *Hate
MH  - History, 16th Century
MH  - History, 17th Century
MH  - History, 19th Century
MH  - History, 20th Century
MH  - Protestantism/history/psychology
MH  - *Psychoanalysis/education/history
MH  - Psychoanalytic Interpretation
MH  - *Religion/history
EDAT- 2011/04/09 06:00
MHDA- 2011/06/24 06:00
CRDT- 2011/04/09 06:00
PHST- 2011/04/09 06:00 [entrez]
PHST- 2011/04/09 06:00 [pubmed]
PHST- 2011/06/24 06:00 [medline]
AID - 10.3366/pah.2011.0002 [doi]
PST - ppublish
SO  - Psychoanal Hist. 2011;13(1):5-24. doi: 10.3366/pah.2011.0002.


PMID- 21465002
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20191210
IS  - 0882-2786 (Print)
IS  - 0882-2786 (Linking)
VI  - 26 Suppl
DP  - 2011
TI  - Health technology assessment in oral health.
PG  - 93-100; discussion 101-2
AB  - Health-care costs are rising at an alarmingly fast rate worldwide, particularly
      in developed countries such as the United States. This is predominantly a result 
      of the development of new, high-cost health technologies intended for improved
      diagnosis and treatment. The purpose of health technology assessment is to
      systematically determine the true benefits of new technologies, taking into
      account clinical efficacy/effectiveness and cost as well as societal preference
      and ethical issues. In this report, the purpose of health technology assessment
      is explained in light of new developments in oral health technology, particularly
      intraoral implants. This information is intended to educate and to challenge oral
      health opinion leaders to consider all of the issues involved in the development 
      and diffusion of new oral health technologies.
FAU - Esfandiari, Shahrokh
AU  - Esfandiari S
AD  - Faculty of Dentistry, Oral Health and Society Research Unit, McGill University,
      Montreal, Quebec, Canada. shahrokh.esfandiari@mcgill.ca
FAU - Feine, Jocelyne
AU  - Feine J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Int J Oral Maxillofac Implants
JT  - The International journal of oral & maxillofacial implants
JID - 8611905
RN  - 0 (Dental Implants)
SB  - IM
MH  - Attitude to Health
MH  - Cost-Benefit Analysis
MH  - Dental Implants/economics/ethics/standards
MH  - Ethics, Dental
MH  - Health Care Costs
MH  - Humans
MH  - Oral Health
MH  - Outcome Assessment, Health Care
MH  - *Technology Assessment, Biomedical/economics/ethics/standards
MH  - *Technology, Dental/economics/ethics/standards
MH  - Technology, High-Cost
MH  - United States
EDAT- 2011/04/09 06:00
MHDA- 2011/06/03 06:00
CRDT- 2011/04/06 06:00
PHST- 2011/04/06 06:00 [entrez]
PHST- 2011/04/09 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
PST - ppublish
SO  - Int J Oral Maxillofac Implants. 2011;26 Suppl:93-100; discussion 101-2.


PMID- 21471909
OWN - NLM
STAT- MEDLINE
DCOM- 20110616
LR  - 20161125
IS  - 1357-6321 (Print)
IS  - 1357-6321 (Linking)
VI  - 17
IP  - 3
DP  - 2011 Mar
TI  - Overcoming the hurdles: setting up clinical trials in three UK hospices.
PG  - 131-4
AB  - Three nurses, all experienced in palliative care but new to a research role, were
      employed by a Comprehensive Local Research Network to form part of the first
      network of 'research-active hospices' in the UK. This article outlines the
      challenges and hurdles faced by the research nurses and illustrates how their
      achievements can be capitalized on to ensure that future research nurses have a
      greater insight into the research process when undertaking clinical palliative
      care research studies in a non-NHS setting. The research nurses' experiences have
      highlighted issues that need addressing, particularly in relation to research
      governance-ethical and Research and Development approval for National Institute
      for Health Research portfolio studies being undertaken in what are effectively
      classed as non-NHS institutions with NHS patients. These issues are hopefully now
      being taken forward by those responsible for policy-making, ensuring that an
      ever-growing population of palliative care patients involved with hospice
      services has the same access to participation in research as other NHS patients.
FAU - Dunleavy, Lesley
AU  - Dunleavy L
AD  - St Catherine's Hospice, Preston, UK. lesley.dunleavy@nhs.net
FAU - Griggs, Anita
AU  - Griggs A
FAU - Wiley, Gail
AU  - Wiley G
FAU - Hughes, Mandy
AU  - Hughes M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Palliat Nurs
JT  - International journal of palliative nursing
JID - 9506762
MH  - *Clinical Trials as Topic
MH  - Hospices/*organization & administration
MH  - *Palliative Care
MH  - State Medicine
MH  - United Kingdom
EDAT- 2011/04/08 06:00
MHDA- 2011/06/17 06:00
CRDT- 2011/04/08 06:00
PHST- 2011/04/08 06:00 [entrez]
PHST- 2011/04/08 06:00 [pubmed]
PHST- 2011/06/17 06:00 [medline]
AID - 10.12968/ijpn.2011.17.3.131 [doi]
PST - ppublish
SO  - Int J Palliat Nurs. 2011 Mar;17(3):131-4. doi: 10.12968/ijpn.2011.17.3.131.


PMID- 21471902
OWN - NLM
STAT- MEDLINE
DCOM- 20110608
LR  - 20181201
IS  - 0966-0461 (Print)
IS  - 0966-0461 (Linking)
VI  - 20
IP  - 6
DP  - 2011 Mar 24-Apr 14
TI  - Evaluation of three commonly used pressure ulcer risk assessment scales.
PG  - S27-8, S30, S32 Passim
AB  - UNLABELLED: Pressure ulcers are a huge concern for health professionals, cause
      suffering to patients and are associated with increased morbidity. AIM: This
      literature review provides an overview of the literature on the three most
      commonly used pressure ulcer risk assessment scales-the Waterlow scale, the
      Braden scale and the Norton scale. METHOD: A search was undertaken through the
      databases CINAHL, MEDLINE, British Nursing Index, ProQuest and Cochrane Library. 
      Key terms included pressure ulcers, pressure sores, risk assessment, Braden
      scale, Norton scale and Waterlow scale. RESULTS: While risk assessment scales are
      beneficial they should not be used without the aid of nurses' clinical judgment. 
      Over-predicting pressure ulcers is a common problem when using risk assessment
      scales. However, ethical considerations preclude investigation into the
      predictive capacity of a scale. Ongoing education in the prevention and
      management of pressure ulcers is essential for nurses. Risk assessment scales
      should be adapted to suit the needs of the clinical setting in which they are
      used. CONCLUSION: The Waterlow scale is the most widely used risk assessment
      scale in the UK and Ireland, even though there is no evidence to suggest it is
      more effective than the other most commonly used scales.
FAU - O'Tuathail, Claire
AU  - O'Tuathail C
AD  - Aras Mayola, School of Nursing and Midwifery, National University of Ireland,
      Galway, Ireland.
FAU - Taqi, Rebecca
AU  - Taqi R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Br J Nurs
JT  - British journal of nursing (Mark Allen Publishing)
JID - 9212059
MH  - Humans
MH  - Nursing Assessment/*methods/*statistics & numerical data
MH  - Pressure Ulcer/*epidemiology/*nursing
MH  - Risk Assessment/methods/statistics & numerical data
MH  - Risk Factors
MH  - United Kingdom/epidemiology
EDAT- 2011/04/08 06:00
MHDA- 2011/06/09 06:00
CRDT- 2011/04/08 06:00
PHST- 2011/04/08 06:00 [entrez]
PHST- 2011/04/08 06:00 [pubmed]
PHST- 2011/06/09 06:00 [medline]
AID - 10.12968/bjon.2011.20.Sup2.S27 [doi]
PST - ppublish
SO  - Br J Nurs. 2011 Mar 24-Apr 14;20(6):S27-8, S30, S32 Passim. doi:
      10.12968/bjon.2011.20.Sup2.S27.


PMID- 21471843
OWN - NLM
STAT- MEDLINE
DCOM- 20120228
LR  - 20111114
IS  - 1524-4040 (Electronic)
IS  - 0148-396X (Linking)
VI  - 69
IP  - 2 Suppl Operative
DP  - 2011 Dec
TI  - Results of a prospective randomized study comparing a novel retractor with a
      Caspar retractor in anterior cervical surgery.
PG  - ons156-60; discussion ons160
LID - 10.1227/NEU.0b013e318219565f [doi]
AB  - BACKGROUND: Retraction injury might explain the soft tissue complications seen
      after anterior cervical surgery. A novel retractor system (Seex retractor system 
      [SRS]) that uses a principle of bone fixation with rotation has been shown to
      reduce retraction pressure in a cadaveric model of anterior cervical
      decompression and fusion. OBJECTIVE: To compare the conventional Cloward-style
      retractor (CRS) with the SRS in a prospective randomized clinical trial. METHODS:
      After ethics and study registration (ACTRN 12608000430336), eligible patients
      were randomized to either the CRS or SRS before 1- or 2-level anterior cervical
      decompression and fusion. The pressure beneath the medial retractor blade was
      recorded with a thin pressure transducer strip. Postoperative sore throat,
      dysphagia, and dysphonia were assessed after 1, 7, and 28 days. RESULTS:
      Twenty-six patients were randomized. There were no serious complications.
      Complication rates were low with a trend favoring SRS that was not statistically 
      different. Average retraction pressure with SRS was 1.9 mm Hg and with CRS was
      5.6 mm Hg (P < .001 on F test; P = .002 on 2-tailed t test). Mean average peak
      retraction pressure with the SRS was 3.4 mm Hg and with the CRS was 20 mm Hg (P <
      .001 on F test; P = .005 on 2-tailed t test). CONCLUSION: The new retractor is
      safe, and statistically similar complication rates were observed with the 2
      systems. The SRS generated significantly less retraction pressure compared with
      the CRS. This difference can be explained by the different principles governing
      the function of these retractors. Bone fixation gives stability and rotation
      reduces tissue pressure, both desirable in a retractor.
FAU - Pattavilakom, Ananthababu
AU  - Pattavilakom A
AD  - Department of Neurosurgery, Nepean Hospital, Penrith, Australia.
      ananthababu@hotmail.com
FAU - Seex, Kevin A
AU  - Seex KA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Neurosurgery
JT  - Neurosurgery
JID - 7802914
SB  - IM
MH  - Cervical Vertebrae/surgery
MH  - Decompression, Surgical/instrumentation
MH  - Deglutition Disorders/epidemiology
MH  - Diskectomy/instrumentation
MH  - Humans
MH  - Pharyngitis/epidemiology
MH  - Spinal Fusion/*instrumentation
MH  - *Surgical Instruments/adverse effects
EDAT- 2011/04/08 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/04/08 06:00
PHST- 2011/04/08 06:00 [entrez]
PHST- 2011/04/08 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - 10.1227/NEU.0b013e318219565f [doi]
PST - ppublish
SO  - Neurosurgery. 2011 Dec;69(2 Suppl Operative):ons156-60; discussion ons160. doi:
      10.1227/NEU.0b013e318219565f.


PMID- 21471705
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20220318
IS  - 1661-7819 (Electronic)
IS  - 1661-7800 (Linking)
VI  - 100
IP  - 2
DP  - 2011
TI  - The French Society of Neonatology's proposals for neonatal end-of-life
      decision-making.
PG  - 206-14
LID - 10.1159/000324119 [doi]
AB  - BACKGROUND: Opinions and practice regarding end-of-life decisions in neonatal
      medicine show considerable variations between countries. A recent change of the
      legal framework, together with an ongoing debate among French neonatologists, led
      the French Society of Neonatology to reconsider and update its previous
      recommendations. OBJECTIVES: To propose a set of recommendations on the ethical
      principles to be respected in the making and application of end-of-life
      decisions. METHODS: A multidisciplinary working group on ethical issues in
      perinatal medicine composed of neonatologists, obstetricians and ethicists.
      RESULTS: Withholding or withdrawing life-sustaining treatment may be acceptable, 
      and unreasonable therapeutic obstinacy is condemned. This implies that the
      child's best interests must always be the central consideration. Although the
      parents must be involved in the decision process so that they form an alliance
      with the healthcare team, and a collegial approach is of utmost importance, any
      crucial decision affecting the patient's life calls for individual medical
      responsibility. Because every newborn is rightfully an integral member of a human
      family, his or her dignity must be preserved. The goal of palliative care is to
      preserve the quality of a life, also at its end. The intention underlying an act 
      has to be analyzed perceptively. Euthanasia, i.e. to perform an act with the
      deliberate intention to cause or hasten a patient's death, is legally and morally
      forbidden. Conversely, to withhold or withdraw a life-sustaining treatment can be
      justified when the intention is to cease opposing, in an unreasonable manner, the
      natural course of a disease. CONCLUSIONS: This statement provides the principles 
      identified by French neonatologists on which to base their decisions concerning
      the ending of life. Arguments are set forth, discussed and compared with
      international statements and previously published considerations.
CI  - Copyright (c) 2011 S. Karger AG, Basel.
FAU - Dageville, C
AU  - Dageville C
AD  - Neonatal Intensive Care Unit, Division of Pediatrics, University Hospital, Nice, 
      France.
FAU - Betremieux, P
AU  - Betremieux P
FAU - Gold, F
AU  - Gold F
FAU - Simeoni, U
AU  - Simeoni U
CN  - Working Group on Ethical Issues in Perinatology
LA  - eng
PT  - Consensus Development Conference
PT  - Journal Article
DEP - 20110401
PL  - Switzerland
TA  - Neonatology
JT  - Neonatology
JID - 101286577
SB  - IM
CIN - Neonatology. 2011;100(2):215-6. PMID: 21654182
MH  - Decision Making/*ethics
MH  - Ethics, Medical
MH  - France
MH  - Humans
MH  - Infant, Newborn
MH  - *Neonatology
MH  - Palliative Care
MH  - Quality of Life
MH  - *Societies, Medical
MH  - Terminal Care/ethics/*trends
IR  - Simeoni U
FIR - Simeoni, Umberto
IR  - Altavilla AG
FIR - Altavilla, Anna-Grazia
IR  - Andrini P
FIR - Andrini, Pierre
IR  - Aujard Y
FIR - Aujard, Yannick
IR  - Azria E
FIR - Azria, Elie
IR  - Betremieux P
FIR - Betremieux, Pierre
IR  - Caeymaex L
FIR - Caeymaex, Laurence
IR  - Collet M
FIR - Collet, Michel
IR  - Dageville C
FIR - Dageville, Christian
IR  - Danan C
FIR - Danan, Claude
IR  - Debillon T
FIR - Debillon, Thierry
IR  - Dehan M
FIR - Dehan, Michel
IR  - Denizot S
FIR - Denizot, Sophie
IR  - Dommergues M
FIR - Dommergues, Marc
IR  - Farnoux C
FIR - Farnoux, Caroline
IR  - Fournie A
FIR - Fournie, Alain
IR  - Gold F
FIR - Gold, Francis
IR  - Gouyon J
FIR - Gouyon, Jean- Bernard
IR  - Grassin M
FIR - Grassin, Marc
IR  - Guidicelli B
FIR - Guidicelli, Beatrice
IR  - Huillery ML
FIR - Huillery, Marie-Luce
IR  - Jarreau PH
FIR - Jarreau, Pierre-Henri
IR  - Kuhn P
FIR - Kuhn, Pierre
IR  - Le Coz P
FIR - Le Coz, Pierre
IR  - Lequien P
FIR - Lequien, Pierre
IR  - Mahieu-Caputo D
FIR - Mahieu-Caputo, Dominique
IR  - Moriette G
FIR - Moriette, Guy
IR  - Oriot D
FIR - Oriot, Denis
IR  - Parat S
FIR - Parat, Sophie
IR  - Puech F
FIR - Puech, Francis
IR  - Rameix S
FIR - Rameix, Suzanne
IR  - Roze JC
FIR - Roze, Jean-Christophe
IR  - Storme L
FIR - Storme, Laurent
EDAT- 2011/04/08 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/04/08 06:00
PHST- 2010/09/01 00:00 [received]
PHST- 2011/01/01 00:00 [accepted]
PHST- 2011/04/08 06:00 [entrez]
PHST- 2011/04/08 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - 000324119 [pii]
AID - 10.1159/000324119 [doi]
PST - ppublish
SO  - Neonatology. 2011;100(2):206-14. doi: 10.1159/000324119. Epub 2011 Apr 1.


PMID- 21471031
OWN - NLM
STAT- MEDLINE
DCOM- 20110722
LR  - 20110407
IS  - 1552-7409 (Electronic)
IS  - 0894-3184 (Linking)
VI  - 24
IP  - 2
DP  - 2011 Apr
TI  - An ethical exploration of quality and safety initiatives in nurse practice.
PG  - 107-10
LID - 10.1177/0894318411399471 [doi]
AB  - Current professional healthcare literature is filled with the call for quality
      and safety initiatives in the provision of healthcare. The popular media
      frequently reports on the need for healthcare reform and the need for cost-saving
      measures as healthcare costs skyrocket. Reported medical and nurse errors are on 
      the rise and the discipline of nursing is responding to the call with
      interprofessional quality and safety initiatives that are intended to reduce
      errors and promote safety in cross-disciplinary healthcare practices. This column
      begins an ethical exploration on the topic from a humanbecoming theoretical
      perspective regarding the need for theory-guided nurse practice and possible
      meanings and implications for future disciplinary nurse practice.
FAU - Milton, Constance L
AU  - Milton CL
AD  - California Baptist University, 8432 Magnolia Avenue, Riverside, CA 92504, USA.
      constancemilton@yahoo.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Nurs Sci Q
JT  - Nursing science quarterly
JID - 8805022
MH  - Cost Savings
MH  - *Ethics, Nursing
MH  - Health Care Reform
MH  - Medical Errors/*prevention & control
MH  - Professional Competence
MH  - *Quality of Health Care
MH  - *Safety Management
MH  - United States
EDAT- 2011/04/08 06:00
MHDA- 2011/07/23 06:00
CRDT- 2011/04/08 06:00
PHST- 2011/04/08 06:00 [entrez]
PHST- 2011/04/08 06:00 [pubmed]
PHST- 2011/07/23 06:00 [medline]
AID - 24/2/107 [pii]
AID - 10.1177/0894318411399471 [doi]
PST - ppublish
SO  - Nurs Sci Q. 2011 Apr;24(2):107-10. doi: 10.1177/0894318411399471.


PMID- 21470766
OWN - NLM
STAT- MEDLINE
DCOM- 20120125
LR  - 20220311
IS  - 1872-7654 (Electronic)
IS  - 0301-2115 (Linking)
VI  - 157
IP  - 2
DP  - 2011 Aug
TI  - Relationship between adenomyosis and uterine polyps.
PG  - 185-9
LID - 10.1016/j.ejogrb.2011.02.014 [doi]
AB  - OBJECTIVE: To evaluate whether adenomyosis is associated with uterine polyps.
      STUDY DESIGN: To perform an ethical human study, we planned a large retrospective
      observational study covering the entire patient population of the ULSS 17-Veneto 
      district who underwent resectoscopy in 2007 and 2008 (959 patients). We enrolled 
      all the patients underwent resectoscopy with resection of uterine polyps, with
      resection of myomas, with endometrial ablations by slicing, and with endometrial 
      biopsies in both the presence and absence of hysteroscopically visible lesions.
      The diagnosis of adenomyosis was made by pathological examination of tissue
      specimens obtained using a resectoscope loop. Multivariate logistic regression
      was performed to determine if adenomyosis was one of the various risk factors for
      the presence and number of uterine polyps. Statistical Package for the Social
      Sciences (SPSS 16.0) was employed, and p</=0.05 was the minimum for significance.
      RESULTS: Age (p=0.005), adenomyosis (p=0.013), high fasting glucose levels
      (p=0.004), and hypertension (p=0.045) were significantly associated with
      endometrial polyps. The presence of multiple endometrial polyps seemed to be
      associated with the presence of adenomyosis (p=0.016). The presence of cervical
      polyps was significantly associated only with presence of adenomyosis (p=0.002). 
      The presence of multiple cervical polyps did not seem to be influenced by any of 
      the variables considered. CONCLUSIONS: The results clearly demonstrate an
      association between adenomyosis and uterine polyps. The pathogenetic role of
      adenomyosis in the development of polyps should therefore be investigated
      further.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Indraccolo, Ugo
AU  - Indraccolo U
AD  - Department of Surgical Sciences, University of Foggia, Italy.
      ugo.indraccolo@libero.it
FAU - Barbieri, Fabrizio
AU  - Barbieri F
LA  - eng
PT  - Journal Article
DEP - 20110405
PL  - Ireland
TA  - Eur J Obstet Gynecol Reprod Biol
JT  - European journal of obstetrics, gynecology, and reproductive biology
JID - 0375672
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Blood Glucose/metabolism
MH  - Endometriosis/*complications/epidemiology
MH  - Female
MH  - Humans
MH  - Hypertension/complications/epidemiology
MH  - Italy
MH  - Logistic Models
MH  - Middle Aged
MH  - Polyps/blood/epidemiology/*etiology
MH  - Prevalence
MH  - Retrospective Studies
MH  - Uterine Diseases/blood/epidemiology/*etiology
EDAT- 2011/04/08 06:00
MHDA- 2012/01/26 06:00
CRDT- 2011/04/08 06:00
PHST- 2010/08/18 00:00 [received]
PHST- 2011/01/09 00:00 [revised]
PHST- 2011/02/27 00:00 [accepted]
PHST- 2011/04/08 06:00 [entrez]
PHST- 2011/04/08 06:00 [pubmed]
PHST- 2012/01/26 06:00 [medline]
AID - S0301-2115(11)00126-6 [pii]
AID - 10.1016/j.ejogrb.2011.02.014 [doi]
PST - ppublish
SO  - Eur J Obstet Gynecol Reprod Biol. 2011 Aug;157(2):185-9. doi:
      10.1016/j.ejogrb.2011.02.014. Epub 2011 Apr 5.


PMID- 21470458
OWN - NLM
STAT- MEDLINE
DCOM- 20110722
LR  - 20211020
IS  - 1080-6059 (Electronic)
IS  - 1080-6040 (Linking)
VI  - 17
IP  - 4
DP  - 2011 Apr
TI  - Remaining questions about clinical variola major.
PG  - 676-80
LID - 10.3201/eid1704.101960 [doi]
AB  - After the recent summary of World Health Organization-authorized research on
      smallpox, several clinical issues remain. This policy review addresses whether
      early hemorrhagic smallpox is disseminated intravascular coagulation and
      speculates about the cause of the high mortality rate among pregnant women and
      whether ocular smallpox is partly the result of trachoma or vitamin A deficiency.
      The joint destruction common in children with smallpox might be prevented by
      antiviral drugs, but intraarticular infusion of antiviral drugs is unprecedented.
      Development of highly effective antiviral drugs against smallpox raises the issue
      of whether postexposure vaccination can be performed without interference by an
      antiviral drug. Clinicians should consider whether patients with smallpox should 
      be admitted to general hospitals. Although an adequate supply of
      second-generation smallpox vaccine exists in the United States, its use is
      unclear. Finally, political and ethical forces suggest that destruction of the
      remaining stocks of live smallpox virus is now appropriate.
FAU - Lane, J Michael
AU  - Lane JM
AD  - Emory University School of Medicine, Atlanta, Georgia, USA. mikelane869@yahoo.com
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Emerg Infect Dis
JT  - Emerging infectious diseases
JID - 9508155
RN  - 0 (Antiviral Agents)
RN  - 0 (Smallpox Vaccine)
SB  - IM
MH  - Animals
MH  - Antiviral Agents/therapeutic use
MH  - Blindness/etiology
MH  - Disseminated Intravascular Coagulation/etiology
MH  - Female
MH  - *Health Policy
MH  - Hemorrhage/etiology
MH  - Humans
MH  - Immune Tolerance
MH  - Joint Diseases/etiology/pathology
MH  - Pregnancy
MH  - *Smallpox/complications/drug therapy/immunology/mortality/prevention & control
MH  - Smallpox Vaccine/administration & dosage/supply & distribution
MH  - Trachoma/complications/etiology
MH  - Vaccination
PMC - PMC3377426
EDAT- 2011/04/08 06:00
MHDA- 2011/07/23 06:00
CRDT- 2011/04/08 06:00
PHST- 2011/04/08 06:00 [entrez]
PHST- 2011/04/08 06:00 [pubmed]
PHST- 2011/07/23 06:00 [medline]
AID - 10.3201/eid1704.101960 [doi]
PST - ppublish
SO  - Emerg Infect Dis. 2011 Apr;17(4):676-80. doi: 10.3201/eid1704.101960.


PMID- 21470415
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1744-8603 (Electronic)
IS  - 1744-8603 (Linking)
VI  - 7
DP  - 2011 Apr 6
TI  - Fly-By medical care: Conceptualizing the global and local social responsibilities
      of medical tourists and physician voluntourists.
PG  - 6
LID - 10.1186/1744-8603-7-6 [doi]
AB  - BACKGROUND: Medical tourism is a global health practice where patients travel
      abroad to receive health care. Voluntourism is a practice where physicians travel
      abroad to deliver health care. Both of these practices often entail travel from
      high income to low and middle income countries and both have been associated with
      possible negative impacts. In this paper, we explore the social responsibilities 
      of medical tourists and voluntourists to identify commonalities and distinctions 
      that can be used to develop a wider understanding of social responsibility in
      global health care practices. DISCUSSION: Social responsibility is a
      responsibility to promote the welfare of the communities to which one belongs or 
      with which one interacts. Physicians stress their social responsibility to care
      for the welfare of their patients and their domestic communities. When physicians
      choose to travel to another county to provide medical care, this social
      responsibility is expanded to this new community. Patients too have a social
      responsibility to use their community's health resources efficiently and to
      promote the health of their community. When these patients choose to go abroad to
      receive medical care, this social responsibility applies to the new community as 
      well. While voluntourists and medical tourists both see the scope of their social
      responsibilities expand by engaging in these global practices, the social
      responsibilities of physician voluntourists are much better defined than those of
      medical tourists. Guidelines for engaging in ethical voluntourism and training
      for voluntourists still need better development, but medical tourism as a
      practice should follow the lead of voluntourism by developing clearer norms for
      ethical medical tourism. SUMMARY: Much can be learned by examining the social
      responsibilities of medical tourists and voluntourists when they engage in global
      health practices. While each group needs better guidance for engaging in
      responsible forms of these practices, patients are at a disadvantage in
      understanding the effects of medical tourism and organizing responses to these
      impacts. Members of the medical professions and the medical tourism industry must
      take responsibility for providing better guidance for medical tourists.
FAU - Snyder, Jeremy
AU  - Snyder J
AD  - Faculty of Health Sciences, Simon Fraser University, Blusson Hall 11300, 8888
      University Drive Burnaby BC, Canada. jcs12@sfu.ca.
FAU - Dharamsi, Shafik
AU  - Dharamsi S
FAU - Crooks, Valorie A
AU  - Crooks VA
LA  - eng
PT  - Journal Article
DEP - 20110406
PL  - England
TA  - Global Health
JT  - Globalization and health
JID - 101245734
PMC - PMC3083338
EDAT- 2011/04/08 06:00
MHDA- 2011/04/08 06:01
CRDT- 2011/04/08 06:00
PHST- 2010/12/02 00:00 [received]
PHST- 2011/04/06 00:00 [accepted]
PHST- 2011/04/08 06:00 [entrez]
PHST- 2011/04/08 06:00 [pubmed]
PHST- 2011/04/08 06:01 [medline]
AID - 1744-8603-7-6 [pii]
AID - 10.1186/1744-8603-7-6 [doi]
PST - epublish
SO  - Global Health. 2011 Apr 6;7:6. doi: 10.1186/1744-8603-7-6.


PMID- 21470229
OWN - NLM
STAT- MEDLINE
DCOM- 20111219
LR  - 20161125
IS  - 1556-4029 (Electronic)
IS  - 0022-1198 (Linking)
VI  - 56
IP  - 4
DP  - 2011 Jul
TI  - Reverse engineering--rapid prototyping of the skull in forensic trauma analysis.
PG  - 1015-7
LID - 10.1111/j.1556-4029.2011.01764.x [doi]
AB  - Rapid prototyping (RP) comprises a variety of automated manufacturing techniques 
      such as selective laser sintering (SLS), stereolithography, and three-dimensional
      printing (3DP), which use virtual 3D data sets to fabricate solid forms in a
      layer-by-layer technique. Despite a growing demand for (virtual) reconstruction
      models in daily forensic casework, maceration of the skull is frequently assigned
      to ensure haptic evidence presentation in the courtroom. Owing to the progress in
      the field of forensic radiology, 3D data sets of relevant cases are usually
      available to the forensic expert. Here, we present a first application of RP in
      forensic medicine using computed tomography scans for the fabrication of an SLS
      skull model in a case of fatal hammer impacts to the head. The report is intended
      to show that this method fully respects the dignity of the deceased and is
      consistent with medical ethics but nevertheless provides an excellent 3D
      impression of anatomical structures and injuries.
CI  - (c) 2011 American Academy of Forensic Sciences.
FAU - Kettner, Mattias
AU  - Kettner M
AD  - Institute of Forensic Medicine, Center of Legal Medicine, Goethe-University
      Frankfurt/M, Kennedyallee 104, 60596 Frankfurt/M., Germany.
      M.Kettner@med.uni-frankfurt.de
FAU - Schmidt, Peter
AU  - Schmidt P
FAU - Potente, Stefan
AU  - Potente S
FAU - Ramsthaler, Frank
AU  - Ramsthaler F
FAU - Schrodt, Michael
AU  - Schrodt M
LA  - eng
PT  - Journal Article
DEP - 20110406
PL  - United States
TA  - J Forensic Sci
JT  - Journal of forensic sciences
JID - 0375370
SB  - IM
MH  - Forensic Pathology/methods
MH  - Fractures, Comminuted/*diagnostic imaging
MH  - Humans
MH  - Image Processing, Computer-Assisted/*methods
MH  - Imaging, Three-Dimensional/*methods
MH  - *Models, Anatomic
MH  - Skull Fracture, Depressed/*diagnostic imaging
MH  - Tomography, X-Ray Computed
EDAT- 2011/04/08 06:00
MHDA- 2011/12/20 06:00
CRDT- 2011/04/08 06:00
PHST- 2011/04/08 06:00 [entrez]
PHST- 2011/04/08 06:00 [pubmed]
PHST- 2011/12/20 06:00 [medline]
AID - 10.1111/j.1556-4029.2011.01764.x [doi]
PST - ppublish
SO  - J Forensic Sci. 2011 Jul;56(4):1015-7. doi: 10.1111/j.1556-4029.2011.01764.x.
      Epub 2011 Apr 6.


PMID- 21470110
OWN - NLM
STAT- MEDLINE
DCOM- 20111121
LR  - 20211020
IS  - 1873-4286 (Electronic)
IS  - 1381-6128 (Linking)
VI  - 17
IP  - 13
DP  - 2011
TI  - Caenorhabditis elegans-based model systems for antifungal drug discovery.
PG  - 1225-33
AB  - The substantial morbidity and mortality associated with invasive fungal
      infections constitute undisputed tokens of their severity. The continued
      expansion of susceptible population groups (such as immunocompromised
      individuals, patients undergoing extensive surgery, and those hospitalized with
      serious underlying diseases especially in the intensive care unit) and the
      limitations of current antifungal agents due to toxicity issues or to the
      development of resistance, mandate the development of novel antifungal drugs.
      Currently, drug discovery is transitioning from the traditional in vitro
      large-scale screens of chemical libraries to more complex bioassays, including in
      vivo studies on whole animals; invertebrates, such as Caenorhabditis elegans, are
      thus gaining momentum as screening tools. Key pathogenesis features of fungal
      infections, including filament formation, are expressed in certain invertebrate
      and mammalian hosts; among the various potential hosts, C. elegans provides an
      attractive platform both for the study of host-pathogen interactions and the
      identification of new antifungal agents. Advantages of compound screening in this
      facile, relatively inexpensive and not as ethically challenged whole-animal
      context, include the simultaneous assessment of antifungal efficacy and toxicity 
      that could result in the identification of compounds with distinct mechanisms of 
      action, for example by promoting host immune responses or by impeding fungal
      virulence factors. With the recent advent of using predictive models to screen
      for compounds with improved chances of bioavailability in the nematode a priori, 
      high-throughput screening of chemical libraries using the C. elegans-C. albicans 
      antifungal discovery assay holds even greater promise for the identification of
      novel antifungal agents in the near future.
FAU - Anastassopoulou, Cleo G
AU  - Anastassopoulou CG
AD  - Division of Infectious Diseases, Massachusetts General Hospital and Harvard
      Medical School, Boston, Massachusetts 02114, USA.
FAU - Fuchs, Beth Burgwyn
AU  - Fuchs BB
FAU - Mylonakis, Eleftherios
AU  - Mylonakis E
LA  - eng
GR  - P01 AI083214/AI/NIAID NIH HHS/United States
GR  - R01 AI075286/AI/NIAID NIH HHS/United States
GR  - R21 AI079569/AI/NIAID NIH HHS/United States
GR  - P01 AI 083214/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United Arab Emirates
TA  - Curr Pharm Des
JT  - Current pharmaceutical design
JID - 9602487
RN  - 0 (Antifungal Agents)
RN  - 0 (Small Molecule Libraries)
SB  - IM
MH  - Animals
MH  - Antifungal Agents/adverse effects/chemistry/*pharmacology
MH  - Caenorhabditis elegans/*microbiology
MH  - Drug Discovery/*methods
MH  - Fungi/drug effects/physiology
MH  - High-Throughput Screening Assays/methods
MH  - Host-Pathogen Interactions
MH  - Humans
MH  - Mycoses/drug therapy/microbiology
MH  - Small Molecule Libraries
PMC - PMC3719869
MID - NIHMS495636
EDAT- 2011/04/08 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/04/08 06:00
PHST- 2011/03/09 00:00 [received]
PHST- 2011/03/21 00:00 [accepted]
PHST- 2011/04/08 06:00 [entrez]
PHST- 2011/04/08 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - BSP/CPD/E-Pub/000411 [pii]
AID - 10.2174/138161211795703753 [doi]
PST - ppublish
SO  - Curr Pharm Des. 2011;17(13):1225-33. doi: 10.2174/138161211795703753.


PMID- 21469379
OWN - NLM
STAT- MEDLINE
DCOM- 20110504
LR  - 20110406
IS  - 0866-4811 (Print)
IS  - 0866-4811 (Linking)
VI  - 21
IP  - 1
DP  - 2011 Jan
TI  - [Publication ethics: regulation of financial conflicts of interests in medical
      journals].
PG  - 65-71
FAU - Kakuk, Peter
AU  - Kakuk P
AD  - Kozep-europai Egyetem bioetikai kutatokozpont kutatoja. kakukp@dote.hu
LA  - hun
PT  - Journal Article
TT  - Publikacios etika: a penzugyi erdekkonfliktusok szabalyozasa az orvosi
      folyoiratokban.
PL  - Hungary
TA  - Lege Artis Med
JT  - Lege artis medicinae : uj magyar orvosi hirmondo
JID - 9425319
MH  - *Conflict of Interest
MH  - *Drug Industry/economics/ethics/legislation & jurisprudence
MH  - Guidelines as Topic
MH  - Humans
MH  - International Cooperation
MH  - Periodicals as Topic/*economics/*ethics/legislation &
      jurisprudence/standards/trends
MH  - Publishing/*economics/*ethics/legislation & jurisprudence/standards/trends
MH  - Research Support as Topic/economics/*ethics
MH  - Treatment Failure
MH  - Truth Disclosure
MH  - United States
EDAT- 2011/04/08 06:00
MHDA- 2011/05/05 06:00
CRDT- 2011/04/08 06:00
PHST- 2011/04/08 06:00 [entrez]
PHST- 2011/04/08 06:00 [pubmed]
PHST- 2011/05/05 06:00 [medline]
PST - ppublish
SO  - Lege Artis Med. 2011 Jan;21(1):65-71.


PMID- 21389762
OWN - NLM
STAT- MEDLINE
DCOM- 20110721
LR  - 20110310
IS  - 1423-0240 (Electronic)
IS  - 0378-584X (Linking)
VI  - 34 Suppl 1
DP  - 2011
TI  - [Benefit-risk evaluation of new drugs as a basis for decisions on prioritization 
      in hematology/oncology: methodical challenges and problem-solving strategies].
PG  - 6-10
LID - 10.1159/000323064 [doi]
AB  - Innovations in the drug treatment of cancer patients pose several medical and
      ethical challenges. The increasing incidence and prevalence of cancer, in
      combination with the availability of new and usually highly expensive anticancer 
      drugs, are associated with a significant increase in the general costs for the
      treatment of cancer patients. Therefore, the development of scientific strategies
      for judgments on benefits is indispensable. In this paper, the authors analyze
      the benefit assessment and the benefit-risk assessment as a foundation for
      decisions on prioritization in hematology and oncology. In a first step,
      regulatory aspects and shortcomings regarding the design of clinical trials in
      oncology before and after approval of anticancer drugs are identified as factors 
      that contribute to difficulties in establishing the effectiveness of new drugs
      entering the health care market. The authors will conclude with suggestions for
      the improvement of benefit-risk analyses and the generation of scientific data
      necessary for such analyses.
CI  - Copyright (c) 2011 S. Karger AG, Basel.
FAU - Ludwig, Wolf-Dieter
AU  - Ludwig WD
AD  - Klinik fur Hamatologie, Onkologie und Tumorimmunologie, HELIOS Klinikum
      Berlin-Buch, Berlin, Germany. wolf-dieter.ludwig@helios-kliniken.de
FAU - Schildmann, Jan
AU  - Schildmann J
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Nutzen-Risiko-Bewertung neuer Wirkstoffe als Grundlage fur
      Priorisierungsentscheidungen in der Hamatologie/Onkologie: Methodische
      Herausforderungen und Losungsansatze.
DEP - 20110117
PL  - Switzerland
TA  - Onkologie
JT  - Onkologie
JID - 7808556
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Antineoplastic Agents/*economics/*therapeutic use
MH  - Germany
MH  - Health Care Rationing/economics/*ethics
MH  - Health Priorities/economics/*ethics
MH  - Hematology/economics/ethics
MH  - Humans
MH  - Medical Oncology/economics/*ethics
MH  - Neoplasms/*drug therapy/economics
EDAT- 2011/04/08 06:00
MHDA- 2011/07/22 06:00
CRDT- 2011/03/11 06:00
PHST- 2011/03/11 06:00 [entrez]
PHST- 2011/04/08 06:00 [pubmed]
PHST- 2011/07/22 06:00 [medline]
AID - 000323064 [pii]
AID - 10.1159/000323064 [doi]
PST - ppublish
SO  - Onkologie. 2011;34 Suppl 1:6-10. doi: 10.1159/000323064. Epub 2011 Jan 17.


PMID- 21389761
OWN - NLM
STAT- MEDLINE
DCOM- 20110721
LR  - 20110310
IS  - 1423-0240 (Electronic)
IS  - 0378-584X (Linking)
VI  - 34 Suppl 1
DP  - 2011
TI  - [Rationalization, rationing, prioritization: terminology and ethical approaches
      to the allocation of limited resources in hematology/oncology].
PG  - 2-5
LID - 10.1159/000323063 [doi]
AB  - The field of oncology with its numerous high-priced innovations contributes
      considerably to the fact that medical progress is expensive. Additionally, due to
      the demographic changes and the increasing life expectancy, a growing number of
      cancer patients want to profit from this progress. Since resources are limited
      also in the health system, the fair distribution of the available resources
      urgently needs to be addressed. Dealing with scarcity is a typical problem in the
      domain of justice theory; therefore, this article first discusses different
      strategies to manage limited resources: rationalization, rationing, and
      prioritization. It then presents substantive as well as procedural criteria that 
      assist in the just distribution of effective health benefits. There are various
      strategies to reduce the utilization of limited resources: Rationalization means 
      that efficiency reserves are being exhausted; by means of rationing, effective
      health benefits are withheld due to cost considerations. Rationing can occur
      implicitly and thus covertly, e.g. through budgeting or the implementation of
      waiting periods, or explicitly, through transparent rules or policies about
      healthcare coverage. Ranking medical treatments according to their importance
      (prioritization) is often a prerequisite for rationing decisions. In terms of
      requirements of justice, both procedural and substantive criteria (e.g. equality,
      urgency, benefit) are relevant for the acceptance and quality of a decision to
      limit access to effective health benefits.
CI  - Copyright (c) 2011 S. Karger AG, Basel.
FAU - Winkler, Eva
AU  - Winkler E
AD  - Medizinische Klinik und Poliklinik III, Ludwig-Maximilian-Universitat, Munchen,
      Germany. eva.winkler@med.uni-muenchen.de
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Rationalisierung, Rationierung, Priorisierung: Terminologie und ethische
      Begrundungsansatze zur Allokation bei begrenzten Ressourcen in der
      Hamatologie/Onkologie.
DEP - 20110117
PL  - Switzerland
TA  - Onkologie
JT  - Onkologie
JID - 7808556
SB  - IM
MH  - Delivery of Health Care/economics/ethics
MH  - Germany
MH  - Health Care Rationing/*economics/*ethics
MH  - Health Priorities/economics/*ethics
MH  - Hematology/*economics
MH  - Humans
MH  - Medical Oncology/*economics/*ethics
MH  - *Terminology as Topic
EDAT- 2011/04/08 06:00
MHDA- 2011/07/22 06:00
CRDT- 2011/03/11 06:00
PHST- 2011/03/11 06:00 [entrez]
PHST- 2011/04/08 06:00 [pubmed]
PHST- 2011/07/22 06:00 [medline]
AID - 000323063 [pii]
AID - 10.1159/000323063 [doi]
PST - ppublish
SO  - Onkologie. 2011;34 Suppl 1:2-5. doi: 10.1159/000323063. Epub 2011 Jan 17.


PMID- 21468497
OWN - NLM
STAT- MEDLINE
DCOM- 20110830
LR  - 20190911
IS  - 1984-0446 (Electronic)
IS  - 0034-7167 (Linking)
VI  - 64
IP  - 1
DP  - 2011 Jan-Feb
TI  - [Construction of a nursing care concept: contribution for undergraduate nursing
      education].
PG  - 106-13
LID - S0034-71672011000100016 [pii]
AB  - The purpose of this research was to construct a nursing care concept, based on
      the understanding of nurses and students from an undergraduate course. This is a 
      qualitative study. A focus group was used to construct a nursing care concept for
      use in undergraduate teaching. The research was carried out at Faculdade Catolica
      Rainha do Sertao in Quixada, CE, Brazil, from August to December 2007. Three
      categories emerged from the process: the understanding of the care concept,
      nursing care and the meaning of care. The constructed concept involved attitudes 
      of awareness, ethics, zeal, solidarity and love, which express a "know-how" based
      on science, art, ethics and esthetics, directed at individual, family and
      community needs.
FAU - Vale, Eucleia Gomes
AU  - Vale EG
AD  - Departamento de Enfermagem, Universidade Federal do Ceara, Fortaleza, CE.
      eucleavale@yahoo.com.br
FAU - Pagliuca, Lorita Marlena Freitag
AU  - Pagliuca LM
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Construcao de um conceito de cuidado de enfermagem: contribuicao para o ensino de
      graduacao.
PL  - Brazil
TA  - Rev Bras Enferm
JT  - Revista brasileira de enfermagem
JID - 7910105
MH  - *Education, Nursing
MH  - Nursing Care/*standards
MH  - *Nursing Process
EDAT- 2011/04/07 06:00
MHDA- 2011/08/31 06:00
CRDT- 2011/04/07 06:00
PHST- 2009/10/27 00:00 [received]
PHST- 2010/09/26 00:00 [accepted]
PHST- 2011/04/07 06:00 [entrez]
PHST- 2011/04/07 06:00 [pubmed]
PHST- 2011/08/31 06:00 [medline]
AID - S0034-71672011000100016 [pii]
AID - 10.1590/s0034-71672011000100016 [doi]
PST - ppublish
SO  - Rev Bras Enferm. 2011 Jan-Feb;64(1):106-13. doi: 10.1590/s0034-71672011000100016.


PMID- 21468485
OWN - NLM
STAT- MEDLINE
DCOM- 20110830
LR  - 20190911
IS  - 1984-0446 (Electronic)
IS  - 0034-7167 (Linking)
VI  - 64
IP  - 1
DP  - 2011 Jan-Feb
TI  - [Privacy in critical care units: the patient's rights and implications for
      nursing professionals].
PG  - 25-30
LID - S0034-71672011000100004 [pii]
AB  - The purpose of this study was to understand the experiences of nursing
      professionals about the patient's privacy hospitalized in the ICU and their
      implications. This qualitative study based on content analysis revealed the
      following categories: Exposing the patients' body and intimacy: the
      professionals' attitudes and actions; intimacy: difficulties experienced by the
      professionals and the patients' reactions; the lack of intimacy protection of the
      patient: contradictions that arise from the practice. The results point to the
      need for professionals to rethink their achievements in relation to the
      protection of the patient's privacy, by means of acts/attitudes which provide
      security in care actions. Privacy preservation is the patient's right and the
      professional's ethical commitment, giving to people dignity in the care process
      in the ICU.
FAU - Baggio, Maria Aparecida
AU  - Baggio MA
AD  - Programa de Pos-graduacao em Enfermagem, Universidade Federal de Santa Catarina, 
      Florianopolis, SC. mariabaggio@yahoo.com.br
FAU - Pomatti, Dalva Maria
AU  - Pomatti DM
FAU - Bettinelli, Luiz Antonio
AU  - Bettinelli LA
FAU - Erdmann, Alacoque Lorenzini
AU  - Erdmann AL
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Privacidade em unidades de terapia intensiva: direitos do paciente e implicacoes 
      para a enfermagem.
PL  - Brazil
TA  - Rev Bras Enferm
JT  - Revista brasileira de enfermagem
JID - 7910105
MH  - Adult
MH  - *Critical Care
MH  - *Ethics, Nursing
MH  - Female
MH  - Humans
MH  - *Intensive Care Units
MH  - Male
MH  - *Patient Rights
MH  - *Privacy
MH  - Young Adult
EDAT- 2011/04/07 06:00
MHDA- 2011/08/31 06:00
CRDT- 2011/04/07 06:00
PHST- 2009/09/14 00:00 [received]
PHST- 2010/09/12 00:00 [accepted]
PHST- 2011/04/07 06:00 [entrez]
PHST- 2011/04/07 06:00 [pubmed]
PHST- 2011/08/31 06:00 [medline]
AID - S0034-71672011000100004 [pii]
AID - 10.1590/s0034-71672011000100004 [doi]
PST - ppublish
SO  - Rev Bras Enferm. 2011 Jan-Feb;64(1):25-30. doi: 10.1590/s0034-71672011000100004.


PMID- 21468480
OWN - NLM
STAT- MEDLINE
DCOM- 20111025
LR  - 20190907
IS  - 1678-9849 (Electronic)
IS  - 0037-8682 (Linking)
VI  - 44
IP  - 2
DP  - 2011 Mar-Apr
TI  - How effective is dog culling in controlling zoonotic visceral leishmaniasis? A
      critical evaluation of the science, politics and ethics behind this public health
      policy.
PG  - 232-42
LID - S0037-86822011005000014 [pii]
AB  - INTRODUCTION: Zoonotic kala-azar, a lethal disease caused by protozoa of the
      genus Leishmania is considered out of control in parts of the world, particularly
      in Brazil, where transmission has spread to cities throughout most of the
      territory and mortality presents an increasing trend. Although a highly debatable
      measure, the Brazilian government regularly culls seropositive dogs to control
      the disease. Since control is failing, critical analysis concerning the actions
      focused on the canine reservoir was conducted. METHODS: In a review of the
      literature, a historical perspective focusing mainly on comparisons between the
      successful Chinese and Soviet strategies and the Brazilian approach is presented.
      In addition, analyses of the principal studies regarding the role of dogs as risk
      factors to humans and of the main intervention studies regarding the efficacy of 
      the dog killing strategy were undertaken. Brazilian political reaction to a
      recently published systematic review that concluded that the dog culling program 
      lacked efficiency and its effect on public policy were also reviewed. RESULTS: No
      firm evidence of the risk conferred by the presence of dogs to humans was
      verified; on the contrary, a lack of scientific support for the policy of killing
      dogs was confirmed. A bias for distorting scientific data towards maintaining the
      policy of culling animals was observed. CONCLUSIONS: Since there is no evidence
      that dog culling diminishes visceral leishmaniasis transmission, it should be
      abandoned as a control measure. Ethical considerations have been raised regarding
      distorting scientific results and the killing of animals despite minimal or
      absent scientific evidence.
FAU - Costa, Carlos Henrique Nery
AU  - Costa CH
AD  - Departamento de Medicina Comunitaria, Universidade Federal do Piaui, Teresina,
      PI, Brasil. chncosta@gmail.com.br
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20110401
PL  - Brazil
TA  - Rev Soc Bras Med Trop
JT  - Revista da Sociedade Brasileira de Medicina Tropical
JID - 7507456
SB  - IM
MH  - Animals
MH  - Brazil
MH  - Disease Reservoirs/*veterinary
MH  - Dog Diseases/parasitology/*prevention & control/transmission
MH  - Dogs
MH  - Euthanasia, Animal/*ethics
MH  - Humans
MH  - Leishmaniasis, Visceral/*prevention & control/transmission/veterinary
MH  - *Public Policy
MH  - Risk Factors
MH  - Zoonoses
EDAT- 2011/04/07 06:00
MHDA- 2011/10/26 06:00
CRDT- 2011/04/07 06:00
PHST- 2010/05/14 00:00 [received]
PHST- 2010/11/29 00:00 [accepted]
PHST- 2011/04/07 06:00 [entrez]
PHST- 2011/04/07 06:00 [pubmed]
PHST- 2011/10/26 06:00 [medline]
AID - S0037-86822011005000014 [pii]
AID - 10.1590/s0037-86822011005000014 [doi]
PST - ppublish
SO  - Rev Soc Bras Med Trop. 2011 Mar-Apr;44(2):232-42. doi:
      10.1590/s0037-86822011005000014. Epub 2011 Apr 1.


PMID- 21468293
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 2158-8341 (Electronic)
IS  - 2158-8333 (Linking)
VI  - 8
IP  - 2
DP  - 2011 Feb
TI  - Setting up a Death Row Psychiatry Program.
PG  - 19-22
AB  - Death row psychiatry contains a complex set of clinical, ethical, and legal
      questions. This Forensic Files column makes a case for correctional institutions 
      starting death row programs to address these issues through uniform policies. A
      list of the relevant issues is provided. Specific issues discussed include death 
      row psychiatric assessment, considering "justifiable" depression, treating for
      competency to be executed, and balancing boundaries between clinical and forensic
      work.
FAU - Yanofski, Jason
AU  - Yanofski J
AD  - Dr. Yanofski is a forensic and clinical psychiatrist at the Minor Traumatic Brain
      Injury (MTBI) Clinic at US Army Garrison, Bamberg, Germany. Dr. Yanofski trained 
      at Johns Hopkins University in Baltimore, Maryland; University of Texas
      Southwestern in Dallas, Texas; and Yale University in New Haven, Connecticut.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Innov Clin Neurosci
JT  - Innovations in clinical neuroscience
JID - 101549695
PMC - PMC3071089
OTO - NOTNLM
OT  - Forensic psychiatry
OT  - competency
OT  - correctional psychiatry
OT  - death penalty
OT  - mood disorders
EDAT- 2011/04/07 06:00
MHDA- 2011/04/07 06:01
CRDT- 2011/04/07 06:00
PHST- 2011/04/07 06:00 [entrez]
PHST- 2011/04/07 06:00 [pubmed]
PHST- 2011/04/07 06:01 [medline]
PST - ppublish
SO  - Innov Clin Neurosci. 2011 Feb;8(2):19-22.


PMID- 21468290
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1861-8863 (Electronic)
IS  - 1861-8863 (Linking)
VI  - 7
DP  - 2011 Apr 1
TI  - Effectiveness of programmes as part of primary prevention demonstrated on the
      example of cardiovascular diseases and the metabolic syndrome.
PG  - Doc02
LID - 10.3205/hta000093 [doi]
AB  - BACKGROUND: The HTA-report (HTA = Health Technology Assessment) deals with the
      primary prevention of cardiovascular diseases and diabetes mellitus type 2. In
      2009 approximately 356,000 people died in Germany due to cardiovascular diseases.
      According to estimations about 6.3 million people are suffering from diabetes
      mellitus type 2. The interventions that are subsidized by the public health
      insurance are mainly focused on sufficient physical activities, healthy
      nutrition, stress management and the reduction of the consumption of addictive
      drugs and luxury food. OBJECTIVES: Which lifestyle-related measures and/or
      programmes for primary prevention of cardiovascular diseases and of the metabolic
      syndrome are effective? To what extent will the health status be improved by
      these offers? To what extent will existing health resources and skills be
      strengthened by these offers? Are there any differences regarding the
      effectiveness among the interventions with respect to different settings or
      subgroups? Which lifestyle-related interventions and/or programmes for primary
      prevention of cardiovascular diseases and of the metabolic syndrome are
      sustainable and cost-effective? Which outcome parameters are in the view of the
      contributors decisive for the evaluation of the effectiveness? In the view of the
      contributor are there different values between the outcome parameters? In the
      view of the payers and other actors are there different values between the
      outcome parameters? Which ethical and juridical factors have to be considered?
      Which social and/or socio-economic parameters influence the use of the services
      and effectiveness? METHODS: A systematic literature research is done in 35
      databases. For the period 2005 to 2010, reviews, epidemiological and clinical
      studies as well as economical evaluations which deal with primary prevention
      programmes regarding cardiovascular diseases or the metabolic syndrome are
      included. RESULTS: 44 publications meet the inclusion criteria. These studies
      confirm the effectiveness of the primary prevention programmes. Physical activity
      programs seem to have a stronger effect than nutrition programmes. Psychological 
      programmes prove as well effectiveness, if they include cognitive behaviour
      therapy. The identified economical studies indicate that programmes for
      cardiovascular prevention can be conducted cost-effectively. Interventions that
      focus on the general population turn out to be particularly cost-effective and
      sustainable. DISCUSSION: There is a wide range of primary preventive effective
      lifestyle-related interventions with high evidence. The outcomes and results are 
      consistent with the recommendations of the two identified evidence-based
      guidelines regarding the recommendations on lifestyle and healthy nutrition.
      Furthermore, the cost-effectiveness of primary prevention services is proven.
      With regard to the economical studies it is however worth noting that this result
      is based on very few publications. The transferability has to be critically
      assessed as the studies mainly originate from the American health system.
      CONCLUSION: On the whole a comprehensive setting approach with educative,
      somatic, psychosocial and activity therapeutic components is recommended. The
      sustainability of a prevention intervention must be ensured from programme to
      programme. Long-term studies are necessary to make valid statements regarding the
      sustainable effectiveness: There is an essential deficit in the current practiced
      evaluation of the use of primary prevention services provided by the health
      insurance - mainly regarding the comprehensive setting approach - regarding the
      evidence-based evaluation of the prescribed preventive interventions. With regard
      to the ethical, social and economical evaluation the research situation is
      deficient. The situation has to be particularly analyzed for the socially
      deprived and one has to respond to their specific needs for prevention.
FAU - Korczak, Dieter
AU  - Korczak D
AD  - GP Forschungsgruppe, Institut fur Grundlagen- und Programmforschung, Munchen,
      Deutschland.
FAU - Dietl, Markus
AU  - Dietl M
FAU - Steinhauser, Gerlinde
AU  - Steinhauser G
LA  - eng
PT  - Journal Article
DEP - 20110401
PL  - Germany
TA  - GMS Health Technol Assess
JT  - GMS health technology assessment
JID - 101276045
PMC - PMC3070433
OTO - NOTNLM
OT  - EBM
OT  - HTA
OT  - RCT
OT  - accident
OT  - adiposity
OT  - apoplexia
OT  - apoplexy
OT  - behavior therapy
OT  - biomedical technology assessment
OT  - blinded
OT  - blinding
OT  - blood glucose
OT  - blood sugar
OT  - cardiovascular diseases
OT  - care
OT  - cerebrovascular accident
OT  - clinical trial
OT  - clinical trials as topic
OT  - controlled clinical trial
OT  - controlled clinical trials as topic
OT  - cost analysis
OT  - cost control
OT  - cost effectiveness
OT  - cost reduction
OT  - cost-cutting
OT  - cost-effectiveness
OT  - costs
OT  - costs and cost analysis
OT  - decision making
OT  - diabetes mellitus
OT  - economic aspect
OT  - economics
OT  - economics, medical
OT  - effectiveness
OT  - effectiveness, cost
OT  - efficacy
OT  - efficiency
OT  - ethics
OT  - evaluation studies as topic
OT  - evidence based medicine
OT  - evidence-based medicine
OT  - health
OT  - health campaign
OT  - health care action
OT  - health care sector
OT  - health economic studies
OT  - health economics
OT  - health education
OT  - health policy
OT  - health promotion
OT  - health technology assessment
OT  - heart disease
OT  - heart diseases
OT  - high blood pressure
OT  - humans
OT  - hypertension
OT  - insulin resistance
OT  - insult
OT  - judgment
OT  - juridical
OT  - life qualities
OT  - life style
OT  - lipid metabolism
OT  - lipometabolism
OT  - medical assessment
OT  - medical costs
OT  - medical evaluation
OT  - meta analysis
OT  - meta analysis as topic
OT  - meta-analysis
OT  - metabolic syndrome
OT  - metabolic syndrome X
OT  - methods
OT  - models, economic
OT  - movement
OT  - multicenter studies as topic
OT  - multicenter trial
OT  - nutritional physiological phenomena
OT  - overweight
OT  - peer review
OT  - pharmaeconomics
OT  - placebo
OT  - placebo effect
OT  - prevention
OT  - prevention program
OT  - prevention research
OT  - preventive care
OT  - preventive medicine
OT  - primary prevention
OT  - program effectiveness
OT  - program evaluation
OT  - prophylaxis
OT  - prospective studies
OT  - quality of life
OT  - random
OT  - randomisation
OT  - randomised clinical trial
OT  - randomised controlled trial
OT  - randomised trial
OT  - randomization
OT  - randomized clinical trial
OT  - randomized controlled trial
OT  - randomized controlled trials as topic
OT  - randomized trial
OT  - rehabilitation
OT  - relaxation
OT  - research article
OT  - research-article
OT  - review
OT  - review literature
OT  - review literature as topic
OT  - risk assessment
OT  - sensitivity
OT  - sickness costs
OT  - social economic factors
OT  - socioeconomic factors
OT  - socioeconomics
OT  - specifity
OT  - stroke
OT  - systematic review
OT  - technical report
OT  - technology
OT  - technology assessment
OT  - technology assessment, biomedical
OT  - technology evaluation
OT  - technology, medical
OT  - therapy
OT  - treatment
OT  - validation studies
EDAT- 2011/04/07 06:00
MHDA- 2011/04/07 06:01
CRDT- 2011/04/07 06:00
PHST- 2011/04/07 06:00 [entrez]
PHST- 2011/04/07 06:00 [pubmed]
PHST- 2011/04/07 06:01 [medline]
AID - 10.3205/hta000093 [doi]
PST - epublish
SO  - GMS Health Technol Assess. 2011 Apr 1;7:Doc02. doi: 10.3205/hta000093.


PMID- 21468289
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1861-8863 (Electronic)
IS  - 1861-8863 (Linking)
VI  - 7
DP  - 2011 Feb 2
TI  - Informative value of Patient Reported Outcomes (PRO) in Health Technology
      Assessment (HTA).
PG  - Doc01
LID - 10.3205/hta000092 [doi]
AB  - BACKGROUND: "Patient-Reported Outcome" (PRO) is used as an umbrella term for
      different concepts for measuring subjectively perceived health status e. g. as
      treatment effects. Their common characteristic is, that the appraisal of the
      health status is reported by the patient himself. In order to describe the
      informative value of PRO in Health Technology Assessment (HTA) first an overview 
      of concepts, classifications and methods of measurement is given. The overview is
      complemented by an empirical analysis of clinical trials and HTA-reports on
      rheumatoid arthritis and breast cancer in order to report on type, frequency and 
      consequences of PRO used in these documents. METHODS: For both issues systematic 
      reviews of the literature have been performed. The search for methodological
      literature covers the publication period from 1990 to 2009, the search for
      clinical trials of rheumatoid arthritis and breast cancer covers the period 2005 
      to 2009. Both searches were performed in the medical databases of the German
      Institute of Medical Documentation and Information (DIMDI). The search for
      HTA-reports and methodological papers of HTA-agencies was performed in the
      CRD-Databases (CRD = Centre for Reviews and Dissemination) and by handsearching
      the websites of INAHTA member agencies (INAHTA = International Network of
      Agencies for Health Technology Assessment). For all issues specific inclusion and
      exclusion criteria were defined. The methodological quality of randomized
      controlled trials (RCT) was assessed by a modified version of the Cochrane Risk
      of Bias Tool. For the methodological part information extraction from the
      literature is structured by the report's chapters, for the empirical part data
      extraction sheets were constructed. All information is summarized in a
      qualitative manner. RESULTS: Concerning the methodological issues the literature 
      search retrieved 158 documents (87 documents related to definition or
      classification, 125 documents related to operationalisation of PRO). For the
      empirical analyses 225 RCT (rheumatoid arthritis: 77; breast cancer: 148) and 40 
      HTA-reports and method papers were found. The analysis of the methodological
      literature confirms the role of PRO as an umbrella term for a variety of
      different concepts. The newest classification system facilitates the description 
      of PRO measures by construct, target population and the method of measurement.
      Steps of operationalisation involve defining a conceptual framework, instrument
      development, exploration of measurement properties or, possibly, the modification
      of existing instruments. Seven out of 59 RCT analysing the effects of antibody
      therapy for rheumatoid arthritis define PRO as the primary endpoint, 38 trials
      utilize composite measures (ACR, DAS) and ten trials report clinical or
      radiological parameters as the primary endpoint. Six out of 123 chemotherapy
      trials for breast cancer define PRO as the primary endpoint, while 98 trials
      report clinical endpoints (survival, tumour response, progression) in their
      primary analyses. Discrepancies in the number of trials result from inaccurate
      specifications of endpoints in the publications. This distribution is reflected
      in the HTA-reports: while almost all reports on rheumatoid arthritis refer to
      PRO, this is only the case in about half of the reports on breast cancer.
      CONCLUSIONS: As definition and classification of PRO are concerned, coherent
      concepts are found in the literature. Their operationalisation and implementation
      must be guided by scientific principles. The type and frequency of PRO used in
      clinical trials largely depend on the disease analysed. The HTA-community seems
      to pursue the utilization of PRO proactively - in case of missing data the need
      for further research is stated.
FAU - Brettschneider, Christian
AU  - Brettschneider C
AD  - University Medical Center Hamburg-Eppendorf, Department of Medical Sociology and 
      Health Economics, Hamburg, Germany.
FAU - Luhmann, Dagmar
AU  - Luhmann D
FAU - Raspe, Heiner
AU  - Raspe H
LA  - eng
PT  - Journal Article
DEP - 20110202
PL  - Germany
TA  - GMS Health Technol Assess
JT  - GMS health technology assessment
JID - 101276045
PMC - PMC3070434
OTO - NOTNLM
OT  - EBM
OT  - HTA
OT  - HTA report
OT  - HTA-report
OT  - Health Technology Assessment
OT  - RCT
OT  - academic review
OT  - accident
OT  - arthritis, rheumatoid
OT  - biomedical technology assessment
OT  - blinded
OT  - blinded study
OT  - blinded trial
OT  - blinding
OT  - breast cancer
OT  - breast neoplasms
OT  - carcinoma of the breast
OT  - care
OT  - clinical studies
OT  - clinical trials
OT  - clinical trials as topic
OT  - concept
OT  - controlled clinical study
OT  - controlled clinical trial
OT  - controlled clinical trials as topic
OT  - cost analysis
OT  - cost control
OT  - cost effectiveness
OT  - cost reduction
OT  - cost-benefit analyses
OT  - cost-benefit-analyses
OT  - cost-cutting
OT  - cost-effectiveness
OT  - costs
OT  - costs and cost analysis
OT  - cross-over procedure
OT  - cross-over studies
OT  - cross-over trials
OT  - crossover procedure
OT  - decision making
OT  - diagnosis
OT  - double blind
OT  - double blind method
OT  - double blind procedure
OT  - double-blind method
OT  - double-blind procedure
OT  - doubleblind
OT  - economic aspect
OT  - economics
OT  - economics, medical
OT  - effectiveness
OT  - efficacy
OT  - efficiency
OT  - endpoint
OT  - endpoint determination
OT  - ethics
OT  - evaluation studies as topic
OT  - evidence based medicine
OT  - evidence-based medicine
OT  - health
OT  - health economic studies
OT  - health economics
OT  - health policy
OT  - health status
OT  - humans
OT  - judgement
OT  - juridical
OT  - medical assessment
OT  - medical costs
OT  - medical evaluation
OT  - meta analysis
OT  - meta analysis as topic
OT  - meta-analysis
OT  - methods
OT  - models, economic
OT  - multicenter studies
OT  - multicenter studies as topic
OT  - multicenter trial
OT  - multicenter trials
OT  - patient report
OT  - patient reported outcome
OT  - patient satisfaction
OT  - patient statement
OT  - patient-relevant
OT  - patient-relevant endpoint
OT  - patient-reported outcome
OT  - patients
OT  - peer review
OT  - pharmacoeconomics
OT  - placebo
OT  - placebo effect
OT  - placebos
OT  - prevention
OT  - prospective studies
OT  - quality of life
OT  - random
OT  - random allocation
OT  - randomisation
OT  - randomised clinical study
OT  - randomised clinical trial
OT  - randomised controlled study
OT  - randomised controlled trial
OT  - randomised study
OT  - randomised trial
OT  - randomization
OT  - randomized clinical study
OT  - randomized clinical trial
OT  - randomized controlled study
OT  - randomized controlled trial
OT  - randomized controlled trials as topic
OT  - randomized study
OT  - randomized trial
OT  - rehabilitation
OT  - report
OT  - research article
OT  - research-article
OT  - review
OT  - review literature
OT  - review literature as topic
OT  - rheumatoid arthritis
OT  - rights
OT  - risk assessment
OT  - sensitivity
OT  - sickness costs
OT  - single blind
OT  - single blind method
OT  - single blind procedure
OT  - single-blind
OT  - single-blind method
OT  - single-blind procedure
OT  - social economic factors
OT  - socioeconomic factors
OT  - socioeconomics
OT  - specifity
OT  - systematic review
OT  - technical report
OT  - technology
OT  - technology assessment
OT  - technology assessment, biomedical
OT  - technology evaluation
OT  - technology, medical
OT  - therapy
OT  - treatment
OT  - trial, cross-over
OT  - trial, crossover
OT  - triple blind
OT  - triple blind method
OT  - triple blind procedure
OT  - triple-blind procedure
OT  - tripleblind
OT  - tripleblind method
OT  - validation studies
OT  - validation studies as topic
EDAT- 2011/04/07 06:00
MHDA- 2011/04/07 06:01
CRDT- 2011/04/07 06:00
PHST- 2011/04/07 06:00 [entrez]
PHST- 2011/04/07 06:00 [pubmed]
PHST- 2011/04/07 06:01 [medline]
AID - 10.3205/hta000092 [doi]
PST - epublish
SO  - GMS Health Technol Assess. 2011 Feb 2;7:Doc01. doi: 10.3205/hta000092.


PMID- 21468157
OWN - NLM
STAT- MEDLINE
DCOM- 20110621
LR  - 20110406
IS  - 0019-1639 (Print)
IS  - 0019-1639 (Linking)
VI  - 67
IP  - 1
DP  - 2011 Jan-Feb
TI  - [Management, quality of health and occupational safety and hospital organization:
      is integration possible?].
PG  - 93-117
AB  - The evolution of the national and European legislation has progressively
      transformed the working environments into organized environments. Specific models
      for its management are being proposed, which should be integrated into general
      management strategies. In the case of hospitals this integration should consider 
      the peculiar organizational complexity, where the management of the occupational 
      risk needs to be integrated with clinical risk management and economic risk
      management. Resources management should also consider that Occupational Medicine 
      has not a direct monetary benefit for the organisation, but only indirect health 
      consequences in terms of reduction of accidents and occupational diseases. The
      deep and simultaneous analysis of the current general management systems and the 
      current management methods of occupational safety and health protection allows
      one to hyphotesise a possible integration between them. For both of them the Top 
      Management is the main responsible of the quality management strategies and the
      use of specific documents in the managerial process, such as the document of
      risks evaluation in the occupational management and the quality manual in the
      general management, is of paramount importance. An integrated management has also
      the scope to pursue a particular kind of quality management, where ethics and job
      satisfaction are innovative, as established by recent European guidelines,
      management systems and national legislations.
FAU - Corrao, Carmela Romana Natalina
AU  - Corrao CR
AD  - Sapienza Universita di Roma Dipartimento di Sanita Pubblica e Malattie Infettive.
      carmela.corrao@uniroma1.it
LA  - ita
PT  - English Abstract
PT  - Journal Article
TT  - Management e qualita della salute e della sicurezza sul lavoro e organizzazione
      ospedaliera: integrazione possibile?
PL  - Italy
TA  - Ig Sanita Pubbl
JT  - Igiene e sanita pubblica
JID - 0373022
SB  - IM
MH  - Documentation
MH  - *Hospital Administration
MH  - Italy
MH  - Models, Theoretical
MH  - Occupational Health/*legislation & jurisprudence
MH  - Occupational Medicine/legislation & jurisprudence/*organization & administration
MH  - *Quality of Health Care
MH  - Resource Allocation
MH  - Risk Management/organization & administration
MH  - Systems Integration
EDAT- 2011/04/07 06:00
MHDA- 2011/06/22 06:00
CRDT- 2011/04/07 06:00
PHST- 2011/04/07 06:00 [entrez]
PHST- 2011/04/07 06:00 [pubmed]
PHST- 2011/06/22 06:00 [medline]
PST - ppublish
SO  - Ig Sanita Pubbl. 2011 Jan-Feb;67(1):93-117.


PMID- 21467797
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20190724
IS  - 1347-5231 (Electronic)
IS  - 0031-6903 (Linking)
VI  - 131
IP  - 4
DP  - 2011 Apr
TI  - [Pharmacoeconomic evaluation of hypothetical over-the-counter
      angiotensin-converting enzyme (ACE) inhibitors for the prevention of stroke in
      patients with grade I hypertension].
PG  - 571-80
AB  - The effectiveness and safety of angiotensin-converting enzyme (ACE) inhibitors
      for the treatment of hypertension have been confirmed during long-term use.
      Therefore, ACE inhibitors were selected as one candidate for the switch from
      ethical drugs to over-the-counter (OTC) medications. The objective of this study 
      was to perform a cost-effectiveness analysis if ACE inhibitors were switched to
      OTC medications and used by grade I hypertension patients in Japan. We conducted 
      a cost-effectiveness analysis from a social perspective over a lifetime horizon
      using a Markov Model in 50-year-old men and women with grade I hypertension. They
      were divided into 3 groups: 1) untreated group; 2) consultation group visiting a 
      clinic and receiving prescriptions for ACE inhibitors; and 3) OTC group
      purchasing OTC ACE inhibitors. The cost of OTC medications was estimated based on
      a previous study of willingness to pay ( yen7,237/month). Average life
      expectancies in both the OTC and consultation groups were 20.20 for men and 22.63
      for women, while in the untreated group it was 19.97 for men and 22.47 for women.
      Incremental costs per expected life-year (ICER) were yen1,743,557 for men and
      yen8,647,069 for women in the OTC group and yen3,819,861 for men and yen9,639,844
      for women in the consultation group. These results suggest that longer life
      expectancies can be achieved with ACE inhibitors, and the total cost is decreased
      using OTC ACE inhibitors compared with ethical drugs. OTC ACE inhibitors
      therefore appear be a useful alternative for patients who do not have time to
      visit a clinic regularly.
FAU - Uchikura, Takeshi
AU  - Uchikura T
AD  - Division for Evaluation and Analysis of Drug Information, Keio University Faculty
      of Pharmacy, Tokyo, Japan. eric_2432@z8.keio.jp
FAU - Yokoi, Nobuyuki
AU  - Yokoi N
FAU - Hashiguchi, Masayuki
AU  - Hashiguchi M
FAU - Mochizuki, Mayumi
AU  - Mochizuki M
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Yakugaku Zasshi
JT  - Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
JID - 0413613
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - 0 (Nonprescription Drugs)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Angiotensin-Converting Enzyme Inhibitors/*economics
MH  - *Cost-Benefit Analysis
MH  - *Economics, Pharmaceutical
MH  - Female
MH  - Humans
MH  - Hypertension/complications/*drug therapy
MH  - Incidence
MH  - Japan/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Nonprescription Drugs/*economics
MH  - Stroke/economics/epidemiology/etiology/*prevention & control
MH  - Surveys and Questionnaires
EDAT- 2011/04/07 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/04/07 06:00
PHST- 2011/04/07 06:00 [entrez]
PHST- 2011/04/07 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - JST.JSTAGE/yakushi/131.571 [pii]
AID - 10.1248/yakushi.131.571 [doi]
PST - ppublish
SO  - Yakugaku Zasshi. 2011 Apr;131(4):571-80. doi: 10.1248/yakushi.131.571.


PMID- 21467250
OWN - NLM
STAT- MEDLINE
DCOM- 20110902
LR  - 20191210
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 260
IP  - 1
DP  - 2011 Jul
TI  - Hepatic perfusion disorder associated with focal liver lesions: contrast-enhanced
      US patterns--correlation study with contrast-enhanced CT.
PG  - 274-81
LID - 10.1148/radiol.11101454 [doi]
AB  - PURPOSE: To retrospectively compare the detection and characterization of hepatic
      perfusion disorder (HPD) associated with focal liver lesions (FLLs) at contrast
      material-enhanced ultrasonography (US) by using contrast-enhanced computed
      tomography (CT) as the reference standard. MATERIALS AND METHODS: The study was
      approved by the local institutional ethics committee, and informed consent was
      waived. Three hundred fifty patients (mean age, 50 years +/- 11 [standard
      deviation]; age range, 19-82 years; 168 women, 182 men) underwent
      contrast-enhanced US and contrast-enhanced CT between April 2008 and July 2010.
      Two independent readers reviewed contrast-enhanced US images for the detection
      and characterization of HPD. The largest lesion or the lesion best identified at 
      contrast-enhanced US per patient was used for statistical analysis.
      Contrast-enhanced CT was used as the reference standard. Contrast-enhanced US and
      CT interreader agreement of diagnoses was assessed by using the weighted kappa
      coefficient, and influences of lesion size, enhancement covering rate, and liver 
      cirrhosis were evaluated by using logistic regression analysis and the paired
      chi(2) test. Sensitivity, specificity, positive and negative predictive values,
      and accuracy of contrast-enhanced US for HPD detection were calculated. RESULTS: 
      Contrast-enhanced US results showed HPD features similar to those of CT imaging. 
      CT depicted 50 HPDs in 350 patients, and contrast-enhanced US depicted 55 HPDs in
      350 patients. The agreement for HPD diagnosis between US and CT was good (kappa =
      0.749). Sensitivity, specificity, positive predictive value, negative predictive 
      value, and accuracy of contrast-enhanced US were 84.0%, 95.7%, 76.4%, 97.3%, and 
      0.945, respectively. Rapid enhancement coverage (P < .001) and lesion size (P =
      .002) were significant predictors of the occurrence of HPD. Liver cirrhosis did
      not have significant influence for HPD detection (P = .087). Image zooming,
      limited acoustic window, lesion diameter greater than 5 cm, attenuation, and
      blurred images were the main reasons for the false-positive diagnosis of HPD at
      contrast-enhanced US. CONCLUSION: The HPD in FLLs can reliably be detected with
      contrast-enhanced US, which correlated well with contrast-enhanced CT images.
FAU - Zhou, Xiang
AU  - Zhou X
AD  - Department of Ultrasound, West China Hospital, Sichuan University, Guoxue Xiang
      37, Chengdu, Sichuan 610041, China.
FAU - Luo, Yan
AU  - Luo Y
FAU - Peng, Yu-Lan
AU  - Peng YL
FAU - Cai, Wei
AU  - Cai W
FAU - Lu, Qiang
AU  - Lu Q
FAU - Lin, Ling
AU  - Lin L
FAU - Sha, Xiao-Xi
AU  - Sha XX
FAU - Li, Yong-Zhong
AU  - Li YZ
FAU - Zhu, Meng
AU  - Zhu M
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20110405
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - 0 (Phospholipids)
RN  - 0 (contrast agent BR1)
RN  - 4419T9MX03 (Iohexol)
RN  - WS7LR3I1D6 (Sulfur Hexafluoride)
SB  - IM
CIN - Radiology. 2011 Dec;261(3):1002; author reply 1002-3. PMID: 22096005
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Contrast Media
MH  - Female
MH  - Humans
MH  - *Iohexol
MH  - Liver Diseases/*diagnosis
MH  - Male
MH  - Middle Aged
MH  - Peripheral Vascular Diseases/*diagnosis
MH  - *Phospholipids
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Statistics as Topic
MH  - *Sulfur Hexafluoride
MH  - Tomography, X-Ray Computed/*methods
MH  - Ultrasonography/*methods
EDAT- 2011/04/07 06:00
MHDA- 2011/09/03 06:00
CRDT- 2011/04/07 06:00
PHST- 2011/04/07 06:00 [entrez]
PHST- 2011/04/07 06:00 [pubmed]
PHST- 2011/09/03 06:00 [medline]
AID - radiol.11101454 [pii]
AID - 10.1148/radiol.11101454 [doi]
PST - ppublish
SO  - Radiology. 2011 Jul;260(1):274-81. doi: 10.1148/radiol.11101454. Epub 2011 Apr 5.


PMID- 21467204
OWN - NLM
STAT- MEDLINE
DCOM- 20110912
LR  - 20110518
IS  - 1460-2350 (Electronic)
IS  - 0268-1161 (Linking)
VI  - 26
IP  - 6
DP  - 2011 Jun
TI  - Human procreation in unchartered territory: new twists in ethical discussions.
PG  - 1284-7
LID - 10.1093/humrep/der093 [doi]
AB  - Since their validation in mammals, there have been profound ethical discussions
      on the possible applications of somatic cell nuclear transfer, human embryonic
      stem cells and induced pluripotent stem cells to reproductive medicine. This has 
      been the case whether these technologies were considered as direct (i.e. when
      procreation is the ultimate goal) or indirect applications. In most countries,
      the majority of these approaches have been either stringently regulated, or
      regulation has been strongly and consensually suggested. However, this is not
      necessarily the case for possibilities such as same-sex chimaeras or the direct
      differentiation of gametes from somatic cells, skipping a pluripotent cell
      intermediate. The author suggests that the field of reproductive medicine should 
      be more proactive in discussing both current and emerging developments with
      possible implications for human reproduction, even those reaching beyond current 
      paradigms.
FAU - Ramalho-Santos, Joao
AU  - Ramalho-Santos J
AD  - Center for Neuroscience and Cell Biology, Department of Life Sciences, University
      of Coimbra, PO Box 3046, 3001-401 Coimbra, Portugal. jramalho@ci.uc.pt
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110405
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
SB  - IM
MH  - Cloning, Organism/ethics
MH  - Embryonic Stem Cells/cytology
MH  - Humans
MH  - Induced Pluripotent Stem Cells/cytology
MH  - Nuclear Transfer Techniques/*ethics
MH  - Pluripotent Stem Cells/cytology
MH  - Reproductive Medicine/*ethics
MH  - Reproductive Techniques, Assisted/ethics
EDAT- 2011/04/07 06:00
MHDA- 2011/09/13 06:00
CRDT- 2011/04/07 06:00
PHST- 2011/04/07 06:00 [entrez]
PHST- 2011/04/07 06:00 [pubmed]
PHST- 2011/09/13 06:00 [medline]
AID - der093 [pii]
AID - 10.1093/humrep/der093 [doi]
PST - ppublish
SO  - Hum Reprod. 2011 Jun;26(6):1284-7. doi: 10.1093/humrep/der093. Epub 2011 Apr 5.


PMID- 21467110
OWN - NLM
STAT- MEDLINE
DCOM- 20110614
LR  - 20181023
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 342
DP  - 2011 Apr 5
TI  - GH in idiopathic short stature. Is treating a poorly defined illness ethical?
PG  - d2144
LID - 10.1136/bmj.d2144 [doi]
LID - bmj.d2144 [pii]
FAU - Caldwell, Paul J
AU  - Caldwell PJ
LA  - eng
PT  - Comment
PT  - Letter
DEP - 20110405
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
RN  - 12629-01-5 (Human Growth Hormone)
SB  - IM
CON - BMJ. 2011;342:d1248. PMID: 21402668
MH  - Dwarfism/*drug therapy
MH  - Ethics, Medical
MH  - Human Growth Hormone/*therapeutic use
MH  - Humans
EDAT- 2011/04/07 06:00
MHDA- 2011/06/15 06:00
CRDT- 2011/04/07 06:00
PHST- 2011/04/07 06:00 [entrez]
PHST- 2011/04/07 06:00 [pubmed]
PHST- 2011/06/15 06:00 [medline]
AID - 10.1136/bmj.d2144 [doi]
PST - epublish
SO  - BMJ. 2011 Apr 5;342:d2144. doi: 10.1136/bmj.d2144.


PMID- 21467109
OWN - NLM
STAT- MEDLINE
DCOM- 20110614
LR  - 20181023
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 342
DP  - 2011 Apr 5
TI  - GH in idiopathic short stature. Is growth hormone treatment ethical or cost
      effective?
PG  - d2142
LID - 10.1136/bmj.d2142 [doi]
LID - bmj.d2142 [pii]
FAU - Wales, Jerry K
AU  - Wales JK
LA  - eng
PT  - Comment
PT  - Letter
DEP - 20110405
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
RN  - 12629-01-5 (Human Growth Hormone)
SB  - IM
CON - BMJ. 2011;342:c7157. PMID: 21398350
MH  - Cost-Benefit Analysis
MH  - Dwarfism/*drug therapy
MH  - Ethics, Medical
MH  - Human Growth Hormone/*economics
MH  - Humans
EDAT- 2011/04/07 06:00
MHDA- 2011/06/15 06:00
CRDT- 2011/04/07 06:00
PHST- 2011/04/07 06:00 [entrez]
PHST- 2011/04/07 06:00 [pubmed]
PHST- 2011/06/15 06:00 [medline]
AID - 10.1136/bmj.d2142 [doi]
PST - epublish
SO  - BMJ. 2011 Apr 5;342:d2142. doi: 10.1136/bmj.d2142.


PMID- 21467104
OWN - NLM
STAT- MEDLINE
DCOM- 20110614
LR  - 20220316
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 342
DP  - 2011 Apr 5
TI  - Reporting of eligibility criteria of randomised trials: cohort study comparing
      trial protocols with subsequent articles.
PG  - d1828
LID - 10.1136/bmj.d1828 [doi]
LID - bmj.d1828 [pii]
AB  - OBJECTIVE: To determine whether and how eligibility criteria of participants
      prespecified in protocols of randomised trials are reported in subsequent
      articles. DESIGN: Cohort study. SETTING: Protocols submitted to the ethics
      committee of a German medical faculty. DATA SOURCES: 52 trial protocols and 78
      subsequent publications published between 2000 and 2006. MAIN OUTCOME MEASURE:
      Proportion of matching, missing, modified, or newly added eligibility criteria
      between trial protocols and subsequent publications. RESULTS: Differences were
      found between protocols and subsequent publications for all 52 trials.
      Information on eligibility criteria was missing in the publications for all 52
      trials (100%, 95% confidence interval 93% to 100%), modified for 44 (85%, 72% to 
      93%), and newly added for 21 (41%, 27% to 55%). The mean number of eligibility
      criteria for each trial was 25 (range 7-43) and the mean proportion of matching
      eligibility criteria per trial was 50% (95% confidence interval 44% to 55%, range
      13-93). Of 1248 eligibility criteria prespecified in the protocols, 606 (49%, 46%
      to 51%) were matching in subsequent publications, 479 (38%, 36% to 41%) were
      missing, and 163 (13%, 11% to 15%) were modified. 51 eligibility criteria were
      added to publications. Most prespecified eligibility criteria were about
      comorbidity (42%, 39% to 45%), treatment (20%, 18% to 22%), or type or severity
      of illness (17%, 15% to 19%). Most of the missing eligibility criteria (96%, 94% 
      to 97%) and modified eligibility criteria (54%, 46% to 62%) suggested broader
      study populations and most of the added eligibility criteria (86%, 74% to 94%)
      suggested narrower study populations. CONCLUSIONS: Many users of trial
      information rely on published journal articles. These articles generally do not
      reflect the exact definition of the study population as prespecified in the
      protocol. Incomplete or inadequate reporting of eligibility criteria hampers a
      proper assessment of the applicability of trial results.
FAU - Blumle, Anette
AU  - Blumle A
AD  - Department of Medical Biometry and Statistics, Institute of Medical Biometry and 
      Medical Informatics, University Medical Center Freiburg, German Cochrane Center, 
      Berliner Allee 29, 79110 Freiburg, Germany. bluemle@cochrane.de
FAU - Meerpohl, Joerg J
AU  - Meerpohl JJ
FAU - Rucker, Gerta
AU  - Rucker G
FAU - Antes, Gerd
AU  - Antes G
FAU - Schumacher, Martin
AU  - Schumacher M
FAU - von Elm, Erik
AU  - von Elm E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110405
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
SB  - IM
MH  - *Clinical Protocols
MH  - Cohort Studies
MH  - Humans
MH  - *Patient Selection
MH  - *Randomized Controlled Trials as Topic
MH  - Research Design
MH  - Selection Bias
PMC - PMC3071036
EDAT- 2011/04/07 06:00
MHDA- 2011/06/15 06:00
CRDT- 2011/04/07 06:00
PHST- 2011/04/07 06:00 [entrez]
PHST- 2011/04/07 06:00 [pubmed]
PHST- 2011/06/15 06:00 [medline]
AID - 10.1136/bmj.d1828 [doi]
PST - epublish
SO  - BMJ. 2011 Apr 5;342:d1828. doi: 10.1136/bmj.d1828.


PMID- 21466580
OWN - NLM
STAT- MEDLINE
DCOM- 20111109
LR  - 20110810
IS  - 1365-2648 (Electronic)
IS  - 0309-2402 (Linking)
VI  - 67
IP  - 9
DP  - 2011 Sep
TI  - Knowledge mobilized by a critical thinking process deployed by nursing students
      in practical care situations: a qualitative study.
PG  - 1930-40
LID - 10.1111/j.1365-2648.2011.05637.x [doi]
AB  - AIM: This paper is a report of a qualitative study of mobilization of knowledge
      within the critical thinking process deployed by female undergraduate nursing
      students in practical care situations. BACKGROUND: Holistic practice is based on 
      variety of knowledge mobilized by a critical thinking process. Novices and, more 
      specifically, students experience many difficulties in this regard. Therefore, a 
      better understanding of the knowledge they mobilize in their practice is
      important for nurse educators. DESIGN: A qualitative study, guided by grounded
      theory, was carried out. Sixteen nursing students, registered in an undergraduate
      programme in an Eastern Canadian university, were recruited. Descriptions of
      practical care situations were obtained through explicitation interviews in 2007.
      A sociodemographic questionnaire, semi-structured interviews and field notes were
      also used. Data were analysed using an approach based on grounded theory. An
      additional stage of analysis involved data condensation. FINDINGS: Various types 
      of knowledge guide nursing students' practice. These include intrapersonal,
      interpersonal, perceptual, moral/ethical, experiential, practical, scientific and
      contextual knowledge. The mobilization of these types of knowledge is only
      possible when the process of critical thinking has attained a higher level,
      giving rise to a new knowledge that we have termed combinational constructive
      knowledge rather than aesthetic knowledge. CONCLUSION: Clarification of the types
      of knowledge guiding the practice of student nurses and of the role of critical
      thinking in their mobilization could lead to innovative educational strategies.
      The findings provide guidance for the revision and development of both academic
      and clinical training programmes.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Lechasseur, Kathleen
AU  - Lechasseur K
AD  - Nursing Faculty, Universite Laval, Quebec, Quebec, Canada.
      kathleen.lechasseur@fsi.ulaval.ca
FAU - Lazure, Ginette
AU  - Lazure G
FAU - Guilbert, Louise
AU  - Guilbert L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110406
PL  - England
TA  - J Adv Nurs
JT  - Journal of advanced nursing
JID - 7609811
SB  - IM
MH  - Adult
MH  - Canada
MH  - *Decision Making
MH  - Education, Nursing, Baccalaureate
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Holistic Nursing/ethics
MH  - Humans
MH  - *Knowledge
MH  - Nurse-Patient Relations
MH  - Nursing Education Research
MH  - Qualitative Research
MH  - Students, Nursing/*psychology
MH  - *Thinking
MH  - Young Adult
EDAT- 2011/04/07 06:00
MHDA- 2011/11/10 06:00
CRDT- 2011/04/07 06:00
PHST- 2011/04/07 06:00 [entrez]
PHST- 2011/04/07 06:00 [pubmed]
PHST- 2011/11/10 06:00 [medline]
AID - 10.1111/j.1365-2648.2011.05637.x [doi]
PST - ppublish
SO  - J Adv Nurs. 2011 Sep;67(9):1930-40. doi: 10.1111/j.1365-2648.2011.05637.x. Epub
      2011 Apr 6.


PMID- 21466028
OWN - NLM
STAT- MEDLINE
DCOM- 20110518
LR  - 20110406
IS  - 1932-149X (Print)
IS  - 1932-149X (Linking)
VI  - 6
IP  - 1
DP  - 2011 Jan-Feb
TI  - A framework for physician activity during disasters and surge events.
PG  - 39-46
AB  - OBJECTIVES: Delineation of the problem of physician role during disaster
      activations both for disaster responders and for general physicians in a Middle
      East state facility. SETTING: The hospital described has 500 medical-surgical
      beds, 59 intensive care unit beds, eight operating rooms (ORs), and 60 emergency 
      room (ER) beds. Its ER sees 150,000 presentations per year and between 11 and 26 
      multitrauma cases per day. Most casualties are the result of industrial accidents
      (50.5 percent) and road traffic accidents (34 percent). It is the principle
      trauma center for Dubai, UAE. The hospital is also the designated primary
      regional responder for medical, chemical, and biological events. Its disaster
      plan has been activated 10 times in the past 3 years and it is consistently over 
      its bed capacity. INTERVENTIONS: A review of the activity of physicians during
      disaster activations revealed problems of role identification, conflict, and lack
      of training. Interventions included training nonacute teams in reverse triaging
      and responder teams in coordinated emergency care. Both actions were fostered and
      controlled by a Disaster Control Centre and its Committee. RESULTS: Clear
      identification of medical leadership in disaster situations, introduction of a
      process of reverse triage to meet surge based on an ethical framework, and
      improvement of flow through the ER and OR. CONCLUSIONS: Reverse triage can be
      made to work in the Middle East despite its lack of primary healthcare
      infrastructure. Lessons from the restructuring of responder teams may be
      applicable to the deployment to prehospital environments of hospital teams, and
      further development of audit tools is required to measure improvement in these
      areas.
FAU - Griffiths, Jane L
AU  - Griffiths JL
AD  - University of Western Sydney, Sydney, Australia.
FAU - Estipona, Aurora
AU  - Estipona A
FAU - Waterson, James A
AU  - Waterson JA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Disaster Med
JT  - American journal of disaster medicine
JID - 101291100
SB  - IM
MH  - Disaster Planning/*organization & administration
MH  - *Disasters
MH  - Emergency Medical Services/*organization & administration
MH  - Emergency Service, Hospital/organization & administration
MH  - Hospital Bed Capacity
MH  - Humans
MH  - Leadership
MH  - Operating Rooms/organization & administration
MH  - *Physician's Role
MH  - Triage/*organization & administration
MH  - United Arab Emirates
EDAT- 2011/04/07 06:00
MHDA- 2011/05/19 06:00
CRDT- 2011/04/07 06:00
PHST- 2011/04/07 06:00 [entrez]
PHST- 2011/04/07 06:00 [pubmed]
PHST- 2011/05/19 06:00 [medline]
PST - ppublish
SO  - Am J Disaster Med. 2011 Jan-Feb;6(1):39-46.


PMID- 21465958
OWN - NLM
STAT- MEDLINE
DCOM- 20110621
LR  - 20131121
IS  - 0030-9982 (Print)
IS  - 0030-9982 (Linking)
VI  - 61
IP  - 3
DP  - 2011 Mar
TI  - Augmentation of anti-platelet effects of aspirin.
PG  - 304-7
AB  - OBJECTIVE: To establish the anti-platelet or aspirin like effects of flavonoid
      rich food (chocolate). METHODS: This was a non-randomized quasi experimental
      study in which, 65 healthy adult volunteers, 27 males and 38 females,
      participated. The subjects included were healthy, non-smoking adults. Health of
      subjects was evaluated by a questionnaire for which a written informed consent
      was taken prior to admission in the study. Research protocol was approved by the 
      college's, "Research and Ethical committee". Division of subjects into two
      groups, a control group which consumed 100 mgs of oral aspirin and an
      interventional group consuming 100 mgs oral aspirin and 18.75 gms of dark
      chocolate (flavonoid rich), was carried out. The Bleeding time estimation for
      both the groups was done by "Duke Method" of bleeding time estimation. RESULTS:
      Data was analyzed by SPSS 15.0. First, a bivariate analysis was done by comparing
      both the pre-test groups i.e. before consumption of aspirin and also before
      consumption of chocolate and aspirin together through independent t-test Later,
      regression analysis was also done. Bivariate analysis compared both the control
      and interventional groups. After comparing pre-test groups a p-value of 0.798 was
      obtained and after comparing post test groups a p-value of 0.006 was determined. 
      Regression analysis yeilded an R-square of 0.25. CONCLUSION: Chocolate has a
      significant role in augmenting the anti-platelet effects of aspirin.
FAU - Zubair, Muhammad Haseeb
AU  - Zubair MH
AD  - Karachi Medical and Dental College, Karachi.
FAU - Zubair, Muhammad Habib
AU  - Zubair MH
FAU - Zubair, Muhammad Naqeeb
AU  - Zubair MN
FAU - Zubair, Muhammad Mujeeb
AU  - Zubair MM
FAU - Aftab, Tariq
AU  - Aftab T
FAU - Asad, Farah
AU  - Asad F
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - Pakistan
TA  - J Pak Med Assoc
JT  - JPMA. The Journal of the Pakistan Medical Association
JID - 7501162
RN  - 0 (Cyclooxygenase Inhibitors)
RN  - 0 (Flavonoids)
RN  - 0 (Platelet Aggregation Inhibitors)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - Adult
MH  - Aspirin/*pharmacology
MH  - Bleeding Time
MH  - Cacao/*chemistry
MH  - Cyclooxygenase Inhibitors/*pharmacology
MH  - Drug Interactions
MH  - Female
MH  - Flavonoids/*pharmacology
MH  - Humans
MH  - Logistic Models
MH  - Platelet Activation/*drug effects
MH  - Platelet Aggregation Inhibitors/*pharmacology
MH  - Platelet Count
EDAT- 2011/04/07 06:00
MHDA- 2011/06/22 06:00
CRDT- 2011/04/07 06:00
PHST- 2011/04/07 06:00 [entrez]
PHST- 2011/04/07 06:00 [pubmed]
PHST- 2011/06/22 06:00 [medline]
AID - 2662 [pii]
PST - ppublish
SO  - J Pak Med Assoc. 2011 Mar;61(3):304-7.


PMID- 21465923
OWN - NLM
STAT- MEDLINE
DCOM- 20110524
LR  - 20190923
IS  - 0035-8665 (Print)
IS  - 0035-8665 (Linking)
VI  - 157
IP  - 1
DP  - 2011 Mar
TI  - Medical ethics in mountain and wilderness medicine.
PG  - 124-6
FAU - Stokes, S
AU  - Stokes S
AD  - Locum SHO in Emergency Medicine, Leicester Royal Infirmary, Infirmary Square,
      Leicester. suzystokes@doctors.org.uk
FAU - Mackenzie, S
AU  - Mackenzie S
FAU - Thomas, C
AU  - Thomas C
LA  - eng
PT  - Journal Article
PL  - England
TA  - J R Army Med Corps
JT  - Journal of the Royal Army Medical Corps
JID - 7505627
SB  - IM
MH  - Emergency Medical Services/ethics
MH  - *Ethics, Medical
MH  - Humans
MH  - *Mountaineering
MH  - *Wilderness
EDAT- 2011/04/07 06:00
MHDA- 2011/05/25 06:00
CRDT- 2011/04/07 06:00
PHST- 2011/04/07 06:00 [entrez]
PHST- 2011/04/07 06:00 [pubmed]
PHST- 2011/05/25 06:00 [medline]
AID - 10.1136/jramc-157-01-21 [doi]
PST - ppublish
SO  - J R Army Med Corps. 2011 Mar;157(1):124-6. doi: 10.1136/jramc-157-01-21.


PMID- 21465396
OWN - NLM
STAT- MEDLINE
DCOM- 20110823
LR  - 20160707
IS  - 1437-1588 (Electronic)
IS  - 1436-9990 (Linking)
VI  - 54
IP  - 4
DP  - 2011 Apr
TI  - [Strengthening patient involvement in rehabilitation].
PG  - 411-9
LID - 10.1007/s00103-011-1243-z [doi]
AB  - Stronger involvement from the patient in health care is advocated because of the 
      changed role perception, due to the increasing therapeutic possibilities in the
      course of medical progress, thoughts concerning ethical considerations and
      medical legislation, and also on the basis of scientific findings. Different
      levels of personal involvement can be identified: participation in
      decision-making processes, participation in the management of diseases, as well
      as participation on the system level. The implementation of these in health care 
      is still insufficient due to various barriers at different levels. Besides
      barriers on the physicians' side, limited health literacy and low patient
      activation are discussed as obstacles for stronger patient involvement.
      Furthermore, specific adjustments are necessary for implementation in
      rehabilitative health care, especially due to the treatment in a
      multiprofessional team. In a current funding initiative with an emphasis on
      rehabilitation, research projects with a focus on participative healthcare are
      being performed.
FAU - Dirmaier, J
AU  - Dirmaier J
AD  - Institut und Poliklinik fur Medizinische Psychologie, Zentrum fur Psychosoziale
      Medizin, Universitatsklinikum Hamburg-Eppendorf, Martinistrasse 52 (Gebaude W
      26), 20246, Hamburg, Deutschland. dirmaier@uke.uni-hamburg.de
FAU - Harter, M
AU  - Harter M
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Starkung der Selbstbeteiligung in der Rehabilitation.
PL  - Germany
TA  - Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
JT  - Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
JID - 101181368
SB  - IM
MH  - Germany
MH  - Health Services Research/*organization & administration
MH  - Humans
MH  - Patient Participation/*methods
MH  - Rehabilitation/*organization & administration
EDAT- 2011/04/06 06:00
MHDA- 2011/08/24 06:00
CRDT- 2011/04/06 06:00
PHST- 2011/04/06 06:00 [entrez]
PHST- 2011/04/06 06:00 [pubmed]
PHST- 2011/08/24 06:00 [medline]
AID - 10.1007/s00103-011-1243-z [doi]
PST - ppublish
SO  - Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2011
      Apr;54(4):411-9. doi: 10.1007/s00103-011-1243-z.


PMID- 21465320
OWN - NLM
STAT- MEDLINE
DCOM- 20110912
LR  - 20131121
IS  - 1496-8975 (Electronic)
IS  - 0832-610X (Linking)
VI  - 58
IP  - 6
DP  - 2011 Jun
TI  - A comparison between the Boussignac continuous positive airway pressure mask and 
      the venturi mask in terms of improvement in the PaO2/F(I)O2 ratio in morbidly
      obese patients undergoing bariatric surgery: a randomized controlled trial.
PG  - 532-9
LID - 10.1007/s12630-011-9497-3 [doi]
AB  - PURPOSE: This study compared the Boussignac continuous positive airway pressure
      (CPAP) mask with the venturi face mask in terms of the postoperative PaO2/F(I)O2 
      (PF) ratio in morbidly obese patients after bariatric surgery. METHODS: Following
      hospital Research Ethics Board approval and written informed consent, morbidly
      obese (body mass index > 35 kg.m(-2)) patients undergoing bariatric surgery were 
      recruited. The patients were anesthetized and laparoscopic Roux-en-Y gastric
      bypass was performed. Patients were assigned randomly to receive either the
      Boussignac (Boussignac Group) or the venturi face mask (Venturi Group)
      immediately after tracheal extubation. Patients were transported to the
      postanesthesia care unit, and the respective devices were applied for one hour.
      The PF ratio was recorded after tracheal intubation and at one hour and two hours
      post extubation. The percent forced expiratory volume (%FEV1) and the percent
      forced vital capacity (%FVC) were recorded preoperatively and at one hour and two
      hours post extubation. Independent Student's t tests were used for continuous
      variables, and the Chi square test was used for categorical variables. P < 0.05
      was considered statistically significant. RESULTS: Eighty-one patients (Group
      Boussignac, n = 43; Group Venturi, n = 38) completed the study. Mean ages and
      body mass indices were similar in the two groups. At one hour post extubation,
      the PF ratio in the Boussignac Group was 361 (170) compared with 279 (91) in the 
      Venturi Group (P = 0.007), and at two hours post extubation, the PF ratio in the 
      Boussignac Group was 371 (162) compared with 323 (127) in the Venturi Group (P = 
      0.1). The postoperative %FEV(1) and %FVC were comparable in both groups at all
      time points. CONCLUSION: Compared with the venturi mask, the Boussignac CPAP mask
      improves the postoperative PF ratio in morbidly obese patients after bariatric
      surgery. The postoperative %FEV1 and %FVC are comparable for both groups.
FAU - Wong, David T
AU  - Wong DT
AD  - Department of Anesthesia, Toronto Western Hospital, 399 Bathurst St., MC2-405,
      Toronto, ON, M5T 2S8, Canada. david.wong@uhn.on.ca
FAU - Adly, Elaheh
AU  - Adly E
FAU - Ip, Hui Yun Vivian
AU  - Ip HY
FAU - Thapar, Shikha
AU  - Thapar S
FAU - Maxted, Grant R
AU  - Maxted GR
FAU - Chung, Frances F
AU  - Chung FF
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110405
PL  - United States
TA  - Can J Anaesth
JT  - Canadian journal of anaesthesia = Journal canadien d'anesthesie
JID - 8701709
RN  - S88TT14065 (Oxygen)
SB  - IM
CIN - Can J Anaesth. 2011 Oct;58(10):969-70; author reply 970. PMID: 21748663
MH  - Adult
MH  - *Bariatric Surgery
MH  - Continuous Positive Airway Pressure/*instrumentation
MH  - Female
MH  - Forced Expiratory Volume
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity, Morbid/physiopathology/*surgery
MH  - Oxygen/*blood
MH  - Vital Capacity
EDAT- 2011/04/06 06:00
MHDA- 2011/09/13 06:00
CRDT- 2011/04/06 06:00
PHST- 2010/12/16 00:00 [received]
PHST- 2011/03/17 00:00 [accepted]
PHST- 2011/04/06 06:00 [entrez]
PHST- 2011/04/06 06:00 [pubmed]
PHST- 2011/09/13 06:00 [medline]
AID - 10.1007/s12630-011-9497-3 [doi]
PST - ppublish
SO  - Can J Anaesth. 2011 Jun;58(6):532-9. doi: 10.1007/s12630-011-9497-3. Epub 2011
      Apr 5.


PMID- 21465238
OWN - NLM
STAT- MEDLINE
DCOM- 20111021
LR  - 20211020
IS  - 1573-4919 (Electronic)
IS  - 0300-8177 (Linking)
VI  - 354
IP  - 1-2
DP  - 2011 Aug
TI  - Induction of pluripotent stem cells transplantation therapy for ischemic stroke.
PG  - 67-75
LID - 10.1007/s11010-011-0806-5 [doi]
AB  - Stroke can cause permanent neurological damage, complications, and even death.
      However, there is no treatment exists to restore its lost function. Human
      embryonic stems transplantation therapy was a novel and potential therapeutic
      approach for stroke. However, as we have seen, the ethical controversy pertains
      to embryonic stem cell research. Human induced pluripotent stem cells (iPSCs) are
      the latest generation of stem cells that may be a solution to the controversy of 
      using embryonic cells. In our study, we generated iPSCs from adult human
      fibroblasts by introduction of four defined transcription factors (Oct4, Sox2,
      Nanog, and Lin-28). And then, we investigated the efficacy of iPSCs
      transplantation therapy for stroke on the animal models of middle cerebral artery
      occlusion. Surprisingly, we found that transplanted iPSCs migrated to injured
      brain areas, and differentiated into neuron-like cells successfully. After 4-16
      days iPSCs grafting, sensorimotor function of rats has been improved
      significantly. In one word, we may prove that iPSCs therapy in stroke to be an
      effective form of treatment.
FAU - Jiang, Mei
AU  - Jiang M
AD  - Department of Neurology, Shanghai Pudong New Area Gongli Hospital, 219 Miao Pu
      Road, Shanghai 200135, People's Republic of China.
FAU - Lv, Lei
AU  - Lv L
FAU - Ji, Haifeng
AU  - Ji H
FAU - Yang, Xuelian
AU  - Yang X
FAU - Zhu, Wei
AU  - Zhu W
FAU - Cai, Liying
AU  - Cai L
FAU - Gu, Xiaju
AU  - Gu X
FAU - Chai, Changfeng
AU  - Chai C
FAU - Huang, Shu
AU  - Huang S
FAU - Sun, Jian
AU  - Sun J
FAU - Dong, Qiang
AU  - Dong Q
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110405
PL  - Netherlands
TA  - Mol Cell Biochem
JT  - Molecular and cellular biochemistry
JID - 0364456
RN  - 0 (Antigens, Differentiation)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Transcription Factors)
RN  - EC 3.1.3.1 (Alkaline Phosphatase)
SB  - IM
MH  - Alkaline Phosphatase/metabolism
MH  - Animals
MH  - Antigens, Differentiation/metabolism
MH  - Brain Ischemia/*therapy
MH  - Cell Differentiation
MH  - Cells, Cultured
MH  - Cerebral Cortex/pathology
MH  - Coculture Techniques
MH  - Disease Models, Animal
MH  - Female
MH  - Fibroblasts/cytology
MH  - Gait Disorders, Neurologic/therapy
MH  - Humans
MH  - Induced Pluripotent Stem Cells/cytology/metabolism/*transplantation
MH  - Male
MH  - Middle Aged
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Recombinant Proteins/genetics/metabolism
MH  - Recovery of Function
MH  - Stroke/*therapy
MH  - Transcription Factors/genetics/metabolism
MH  - Transplantation, Heterologous
EDAT- 2011/04/06 06:00
MHDA- 2011/10/22 06:00
CRDT- 2011/04/06 06:00
PHST- 2011/01/31 00:00 [received]
PHST- 2011/03/24 00:00 [accepted]
PHST- 2011/04/06 06:00 [entrez]
PHST- 2011/04/06 06:00 [pubmed]
PHST- 2011/10/22 06:00 [medline]
AID - 10.1007/s11010-011-0806-5 [doi]
PST - ppublish
SO  - Mol Cell Biochem. 2011 Aug;354(1-2):67-75. doi: 10.1007/s11010-011-0806-5. Epub
      2011 Apr 5.


PMID- 21464832
OWN - NLM
STAT- MEDLINE
DCOM- 20111004
LR  - 20111103
IS  - 1989-2284 (Electronic)
IS  - 0211-6995 (Linking)
VI  - 31
IP  - 3
DP  - 2011
TI  - Ethical challenges in transplant practice in Latin America: the Aguascalientes
      Document.
PG  - 275-85
LID - 10.3265/Nefrologia.pre2011.Feb.10820 [doi]
AB  - Organ transplants are currently an alternative treatment for a growing number of 
      diseases, which were previously considered terminal. Bioethics has played an
      important role since the advent of this surgical technique, mainly in defining
      death criteria and the optimum transplantation conditions. This issue continues
      being a universal focal point, mainly concerning the equity of access to
      transplantation, criteria for assigning deceased-donor organs, living-donor
      safety, risk of commercial trade, fair access to high-quality immunosuppressive
      drugs and organ transplant legislation. These problems are characteristic of
      Latin America and the Caribbean, and were the driving force behind the First
      Latin American Bioethics and Transplant Forum, sponsored by the Latin American
      and Caribbean Transplant Society (STALYC), and all the transplant societies from 
      subsidiary countries. The "Document of Aguascalientes" is a collection of all the
      ideas and opinions that were proposed during round tables and analyses. The
      document is divided into four sections: 1) living donor; 2) organ trading and
      transplant tourism; 3) the state role in legislation, transplant distribution and
      coverage; and 4) access to and quality of immunosuppression. The Bioethics and
      Transplant Forum was created to analyse and find solutions for this complex
      issue. The "Document of Aguascalientes" aims to serve as an instrument of
      expression and a vehicle for the ideas put forward during the Forum, so that they
      can act as transplant practice guidelines in Latin America.
FAU - Baquero, A
AU  - Baquero A
AD  - Transplant Institute, Dr Baquero Foundation. Santo Domingo. Dominican Republic.
      trasplante_dr@hotmail.com
FAU - Alberu, J
AU  - Alberu J
CN  - Documento de Aguascalientes
LA  - eng
LA  - spa
PT  - Journal Article
DEP - 20110315
PL  - Spain
TA  - Nefrologia
JT  - Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia
JID - 8301215
SB  - IM
MH  - Consensus
MH  - Humans
MH  - Latin America
MH  - Mexico
MH  - Organ Transplantation/*ethics
MH  - Tissue and Organ Procurement/*ethics
IR  - Baquero A
FIR - Baquero, Ashley
IR  - Alberu J
FIR - Alberu, Josefina
IR  - Delpin ES
FIR - Delpin, Eduardo Santiago
IR  - Tanus E
FIR - Tanus, Eduardo
IR  - Acevedo RR
FIR - Acevedo, Rafael Reyes
IR  - Matamoros MA
FIR - Matamoros, Maria Amalia
IR  - Tanus R
FIR - Tanus, Roberto
IR  - Bacile MS
FIR - Bacile, Mariela Salome
IR  - Orihuela S
FIR - Orihuela, Sergio
IR  - Fihlo MA
FIR - Fihlo, Mario Abbud
IR  - Bacque Mdel C
FIR - Bacque, Maria del Carmen
IR  - Casadei D
FIR - Casadei, Domingo
IR  - Figueroa AA
FIR - Figueroa, Alger Aquino
IR  - Arroyo RB
FIR - Arroyo, Roberto Barriga
IR  - Bello Bello MM
FIR - Bello Bello, Martha Magalis
IR  - Bengochea M
FIR - Bengochea, Milka
IR  - Lopez JD
FIR - Lopez, Jorge David Cancino
IR  - Quintanilla GR
FIR - Quintanilla, Guillermo Rafael Cantu
IR  - Jimenez IC
FIR - Jimenez, Irene Cordova
IR  - Perez RE
FIR - Perez, Ramon Espinoza
IR  - Corrales JP
FIR - Corrales, Jose Pablo Garbanzo
IR  - Juarez CG
FIR - Juarez, Carmen Gracida
IR  - Mautone M
FIR - Mautone, Mariela
IR  - Cerriteno JL
FIR - Cerriteno, Jose Luis Medina
IR  - Rangel AM
FIR - Rangel, Avelino Mendez
IR  - Padilla AM
FIR - Padilla, Arnoldo Mondragon
IR  - Cardoso CN
FIR - Cardoso, Cruz Netza
IR  - Rial Mdel C
FIR - Rial, Maria del Carmen
IR  - Allen AR
FIR - Allen, Ana Rodriguez
IR  - Jaramillo Mde L
FIR - Jaramillo, Maria de la Cruz Ruiz
IR  - Panebianco LZ
FIR - Panebianco, Luciano Zylberberg
EDAT- 2011/04/06 06:00
MHDA- 2011/10/05 06:00
CRDT- 2011/04/06 06:00
PHST- 2011/02/26 00:00 [accepted]
PHST- 2011/04/06 06:00 [entrez]
PHST- 2011/04/06 06:00 [pubmed]
PHST- 2011/10/05 06:00 [medline]
AID - 10.3265/Nefrologia.pre2011.Feb.10820 [doi]
PST - ppublish
SO  - Nefrologia. 2011;31(3):275-85. doi: 10.3265/Nefrologia.pre2011.Feb.10820. Epub
      2011 Mar 15.


PMID- 21464467
OWN - NLM
STAT- MEDLINE
DCOM- 20111130
LR  - 20110719
IS  - 1049-7323 (Print)
IS  - 1049-7323 (Linking)
VI  - 21
IP  - 8
DP  - 2011 Aug
TI  - Utilizing participants' strengths to reduce risk of harm in a study of family
      estrangement.
PG  - 1136-46
LID - 10.1177/1049732311405065 [doi]
AB  - In this article I examine some issues involved in researching vulnerable
      populations and sensitive issues, and the challenges and risks of researching
      issues of a deeply personal nature. Participants might have complex needs and
      vulnerabilities, but they also have many resources to ensure their own
      well-being. I ask researchers to move beyond the minimum standards espoused by
      human ethics committees, and utilize participant strengths to further reduce the 
      risk of harm. My reflections on a study of older people who were experiencing
      family estrangement highlight some of the actions that participants used to
      increase their personal safety. I discuss the usefulness of "strengths" questions
      in assessing risk and facilitating participant strengths to minimize harm.
      Finally, I propose a three-way model for reducing risk that involves the "lessons
      learned" from ethics committees, researchers, and the participants themselves.
FAU - Agllias, Kylie
AU  - Agllias K
AD  - University of Newcastle, Newcastle, New South Wales, Australia.
      Kylie.Agllias@newcastle.edu.au
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110404
PL  - United States
TA  - Qual Health Res
JT  - Qualitative health research
JID - 9202144
MH  - Adult Children
MH  - Aged
MH  - Aged, 80 and over
MH  - Community-Based Participatory Research/*ethics/methods
MH  - Ethics Committees, Research/standards
MH  - *Family Relations
MH  - Female
MH  - Harm Reduction
MH  - Human Experimentation/standards
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Middle Aged
MH  - New South Wales
MH  - Qualitative Research
MH  - Researcher-Subject Relations/ethics
MH  - Social Alienation/*psychology
MH  - *Vulnerable Populations
EDAT- 2011/04/06 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/04/06 06:00
PHST- 2011/04/06 06:00 [entrez]
PHST- 2011/04/06 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 1049732311405065 [pii]
AID - 10.1177/1049732311405065 [doi]
PST - ppublish
SO  - Qual Health Res. 2011 Aug;21(8):1136-46. doi: 10.1177/1049732311405065. Epub 2011
      Apr 4.


PMID- 21463720
OWN - NLM
STAT- MEDLINE
DCOM- 20110727
LR  - 20110405
IS  - 1879-3231 (Electronic)
IS  - 0093-691X (Linking)
VI  - 75
IP  - 8
DP  - 2011 May
TI  - Fetal adnexa derived stem cells from domestic animal: progress and perspectives.
PG  - 1400-15
LID - 10.1016/j.theriogenology.2010.12.032 [doi]
AB  - The fetal adnexa such as umbilical cord, amnion and amniotic fluid have been
      proposed as ideal sources of different stem cell lineages. Use of adnexal tissue 
      has many potential advantages, including the noninvasive nature of the isolation 
      procedure, the large tissue mass from which cells can be harvested with high
      efficiency and the potential of these cells to differentiate. Moreover,
      particularly in human medicine, the harvesting of these tissues is more ethically
      acceptable making these sources of stem cells very attractive for regenerative
      therapies and biotechnological applications. The adnexal tissue cells preserve
      some of the characteristics of the primitive embryonic layers from which they
      originate. Indeed, many studies indicate that these stem cells exhibit some
      features of embryonic stem cells as expression of embryonic markers and
      proliferation capability, without showing immunogenicity. However, the
      differentiation potential of these cells, either in vivo or in vitro, is
      intermediate between the pluripotent embryonic stem cells and the multipotent
      adult stem cells. Non-embryonic extra-fetal derived stem cells have opened new
      perspectives for developmental biology and for regenerative medicine, not only in
      humans but also in animals. In this update, we report the state of the art of
      fetal adnexa-derived stem cells from domestic animals and analyze their
      applications and potential uses in veterinary medicine.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Cremonesi, F
AU  - Cremonesi F
AD  - Universita degli Studi di Milano, Faculty of Veterinary Medicine, Via
      dell'Universita 6,-26900 Lodi, Italy.
FAU - Corradetti, B
AU  - Corradetti B
FAU - Lange Consiglio, A
AU  - Lange Consiglio A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Theriogenology
JT  - Theriogenology
JID - 0421510
SB  - IM
MH  - Amnion/*cytology
MH  - Amniotic Fluid/*cytology
MH  - Animals
MH  - Animals, Domestic
MH  - Fetal Blood/*cytology
MH  - Fetal Stem Cells/*physiology
EDAT- 2011/04/06 06:00
MHDA- 2011/07/28 06:00
CRDT- 2011/04/06 06:00
PHST- 2010/08/06 00:00 [received]
PHST- 2010/12/20 00:00 [revised]
PHST- 2010/12/31 00:00 [accepted]
PHST- 2011/04/06 06:00 [entrez]
PHST- 2011/04/06 06:00 [pubmed]
PHST- 2011/07/28 06:00 [medline]
AID - S0093-691X(11)00013-6 [pii]
AID - 10.1016/j.theriogenology.2010.12.032 [doi]
PST - ppublish
SO  - Theriogenology. 2011 May;75(8):1400-15. doi:
      10.1016/j.theriogenology.2010.12.032.


PMID- 21463416
OWN - NLM
STAT- MEDLINE
DCOM- 20110707
LR  - 20191210
IS  - 1753-6405 (Electronic)
IS  - 1326-0200 (Linking)
VI  - 35
IP  - 2
DP  - 2011 Apr
TI  - Vaccines--but not as we know them: an ethical evaluation of HPV vaccination
      policy in Australia.
PG  - 176-9
LID - 10.1111/j.1753-6405.2011.00652.x [doi]
AB  - OBJECTIVE: To show how systematic ethical evaluation of public health policy may 
      reveal issues of moral significance for critical examination. METHOD: Using
      Australia's human papillomavirus (HPV) vaccination program as an exemplar and
      adopting an approach outlined elsewhere, we determine whether conditions of
      effectiveness, proportionality, necessity and least infringement, and public
      justification, are met such that any breach of autonomy or justice principles
      associated with this intervention can be defended. CONCLUSIONS: While the HPV
      vaccine itself may be efficacious, some aspects of the program lack sufficient
      moral justification and raise concerns around procedural and social justice and
      gender equity. IMPLICATIONS: Public health interventions deploying new
      technologies against new targets--such as vaccines against cancer and chronic
      illness--require approaches crafted to their specific risk-benefit profiles that 
      have carefully considered the ethical issues involved. Systematic ethical
      reflection is a useful tool for this.
CI  - (c) 2011 The Authors. ANZJPH (c) 2011 Public Health Association of Australia.
FAU - Rae, Merelyn
AU  - Rae M
AD  - Family Planning New South Wales, Fairfield, New South Wales.
      merelynr@fpnsw.org.au
FAU - Kerridge, Ian
AU  - Kerridge I
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20110307
PL  - Australia
TA  - Aust N Z J Public Health
JT  - Australian and New Zealand journal of public health
JID - 9611095
RN  - 0 (Papillomavirus Vaccines)
SB  - IM
CIN - Aust N Z J Public Health. 2012 Feb;36(1):96. PMID: 22313719
MH  - Adolescent
MH  - Adult
MH  - Australia
MH  - Child
MH  - Female
MH  - Humans
MH  - Papillomavirus Infections/*prevention & control
MH  - *Papillomavirus Vaccines
MH  - Public Health/ethics
MH  - *Public Policy
MH  - Uterine Cervical Neoplasms/prevention & control/virology
MH  - Vaccination/*ethics/methods
MH  - Young Adult
EDAT- 2011/04/06 06:00
MHDA- 2011/07/08 06:00
CRDT- 2011/04/06 06:00
PHST- 2011/04/06 06:00 [entrez]
PHST- 2011/04/06 06:00 [pubmed]
PHST- 2011/07/08 06:00 [medline]
AID - 10.1111/j.1753-6405.2011.00652.x [doi]
PST - ppublish
SO  - Aust N Z J Public Health. 2011 Apr;35(2):176-9. doi:
      10.1111/j.1753-6405.2011.00652.x. Epub 2011 Mar 7.


PMID- 21463226
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20211020
IS  - 1742-8149 (Electronic)
IS  - 1464-7273 (Linking)
VI  - 14
IP  - 2
DP  - 2011 Jun
TI  - Constructing an ethical framework for embryo donation to research: is it time for
      a restricted consent policy?
PG  - 115-21
LID - 10.3109/14647273.2011.557762 [doi]
AB  - An Ethics & Policy Workshop was held with 20 invited UK stakeholders to consider 
      whether embryo donors should be able to restrict the future use of human
      embryonic stem cells (hESCs) created from their embryos. Participants cited
      tensions between pure altruism and a more reciprocal basis for donation; and
      between basic research (in which genetic material would never form part of
      another living being) and treatment applications. Two restriction models were
      suggested to acknowledge specific ethical issues raised by hESCs' use in research
      and treatments: (1) a two tier system: hESCs with unrestricted consent could go
      to the UK Stem Cell Bank; those with restricted consent could be used in
      individual labs which could guarantee to honour the restrictions, and Bank
      deposit would not be required. (2) a three category system: restrictions could
      include (i) basic hESC research; (ii) hESC research and treatment; no gamete
      derivation (iii) 'unrestricted' hESC research and treatment.
FAU - Ehrich, Kathryn
AU  - Ehrich K
AD  - NIHR King's Patient Safety & Service Quality Research Centre, King's College
      London, London, UK. kathryn.ehrich@kcl.ac.uk
FAU - Farsides, Bobbie
AU  - Farsides B
FAU - Williams, Clare
AU  - Williams C
FAU - Scott, Rosamund
AU  - Scott R
LA  - eng
GR  - 086034/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110405
PL  - England
TA  - Hum Fertil (Camb)
JT  - Human fertility (Cambridge, England)
JID - 100888143
SB  - IM
MH  - Embryo Research/*ethics
MH  - Embryonic Stem Cells
MH  - Fetal Tissue Transplantation/*ethics
MH  - Humans
MH  - Parental Consent/*ethics
MH  - Policy
MH  - Stem Cell Transplantation/*ethics
MH  - United Kingdom
EDAT- 2011/04/06 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/04/06 06:00
PHST- 2011/04/06 06:00 [entrez]
PHST- 2011/04/06 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - 10.3109/14647273.2011.557762 [doi]
PST - ppublish
SO  - Hum Fertil (Camb). 2011 Jun;14(2):115-21. doi: 10.3109/14647273.2011.557762. Epub
      2011 Apr 5.


PMID- 21462490
OWN - NLM
STAT- MEDLINE
DCOM- 20110504
LR  - 20110404
IS  - 0241-6972 (Print)
IS  - 0241-6972 (Linking)
IP  - 273
DP  - 2011 Mar-Apr
TI  - [The ethical, legislative and regulatory basis of therapeutic education].
PG  - 16-8
AB  - Beyond its interest in the field of public health and the political aspect with
      the "Hospital, patients, health and territories" law, therapeutic education now
      occupies an important place in nursing care. This new nursing culture provides
      another clinical approach for the nurse and a real means of learning for the
      patient in the framework of a support and guidance plan drawn up together.
FAU - Dodero, Muriel
AU  - Dodero M
AD  - EPS Maison Blanche, Paris. muriel.dodero@ch-maison-blanche.fr
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Les fondements ethiques, legislatifs et reglementaires de l'education
      therapeutique.
PL  - France
TA  - Soins Psychiatr
JT  - Soins. Psychiatrie
JID - 8203334
MH  - France
MH  - Government Regulation
MH  - Health Policy/legislation & jurisprudence
MH  - Humans
MH  - National Health Programs/ethics/organization & administration
MH  - *Nurse's Role
MH  - Patient Care Planning/ethics/organization & administration
MH  - *Patient Education as Topic/ethics/organization & administration
MH  - *Patient Participation/legislation & jurisprudence/methods
MH  - Self Care/ethics
EDAT- 2011/04/06 06:00
MHDA- 2011/05/05 06:00
CRDT- 2011/04/06 06:00
PHST- 2011/04/06 06:00 [entrez]
PHST- 2011/04/06 06:00 [pubmed]
PHST- 2011/05/05 06:00 [medline]
PST - ppublish
SO  - Soins Psychiatr. 2011 Mar-Apr;(273):16-8.


PMID- 21461722
OWN - NLM
STAT- MEDLINE
DCOM- 20130423
LR  - 20211020
IS  - 1433-8726 (Electronic)
IS  - 0724-4983 (Linking)
VI  - 30
IP  - 5
DP  - 2012 Oct
TI  - Initial experience with laparoscopic single-incision triangulated umbilical
      surgery (SITUS) in simple and radical nephrectomy.
PG  - 613-8
LID - 10.1007/s00345-011-0670-7 [doi]
AB  - INTRODUCTION: New transumbilical laparoendoscopic procedures are an emerging
      field in urologic surgery. We introduced the concept of single-incision
      triangulated umbilical surgery (SITUS) in 2009. SITUS technique uses straight
      optics and instruments in a triangulated fashion via three trocars placed through
      an umbilical incision resulting in a familiar laparoscopic environment. Aim of
      the study was to demonstrate the feasibility of SITUS in simple and radical
      nephrectomy in daily routine. MATERIALS AND METHODS: From October 2009 to July
      2010, in 3 patients with cirrhotic kidneys a simple and in 12 patients a radical 
      nephrectomy was performed in SITUS technique. The umbilical fold was incised at
      three-fourth of its circumference; in the patient with radical nephrectomy,
      additionally small "c"-shaped skin flaps were removed. After achieving a
      pneumoperitoneum by Verres technique, a 5-mm camera port and then a cranial 5 mm 
      and a caudal 11 mm working trocar were placed with at a distance of 5-10 cm with 
      the aid of two Langenbeck hooks, thus allowing triangulation except in the
      radical nephrectomy patients, where an 11-mm caudal trocar (Endopath, Ethicon,
      Hamburg, GER) was used. Using long conventional laparoscopic instruments, En-Seal
      pressure coagulator and dissector (Erbe, Tuebingen, Germany), Hem-O-Lock clips
      (Weck, Teleflex, USA), and a 30 degrees 5-mm optic (Karl Storz, Tuttlingen, GER),
      the interventions were executed like conventional laparoscopic transperitoneal
      procedures. RESULTS: OR time was mean 127 min [120, 153] for cirrhotic kidney
      nephrectomy group and mean 137 min [91, 185] in the radical nephrectomy group.
      Mean hemoglobin drop was 1.5 g/dl [1.2, 1.7] in benign cases and 2.4 [1.1, 4.9]
      in radial nephrectomies. All except one diabetic patient with wound infection had
      an uneventful follow-up without postoperative complications. The patients were
      discharged at postoperative day 5 [3, 29]. CONCLUSION: SITUS technique for simple
      and radical nephrectomy is an attractive alternative to conventional laparoscopy 
      and single-port surgery. It combines the common principles of traditional
      laparoscopy (straight instruments and triangulation) with single-port surgery
      (cosmesis and minimally invasiveness) resulting in adequate or time and short
      learning curve.
FAU - Nagele, Udo
AU  - Nagele U
AD  - Department of Urology and Andrology, LandesKrankenhaus Hall i. T., Milser Str.
      10, 6060 Hall i. T., Austria. Udo.Nagele@tilak.at
FAU - Walcher, Ute
AU  - Walcher U
FAU - Herrmann, Thomas R W
AU  - Herrmann TR
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20110402
PL  - Germany
TA  - World J Urol
JT  - World journal of urology
JID - 8307716
SB  - IM
MH  - Aged
MH  - Blood Loss, Surgical
MH  - Female
MH  - Fibrosis/surgery
MH  - Germany
MH  - Humans
MH  - Kidney/surgery
MH  - Kidney Diseases/*surgery
MH  - Kidney Neoplasms/*surgery
MH  - Laparoscopes
MH  - Laparoscopy/instrumentation/*methods
MH  - Male
MH  - Middle Aged
MH  - Nephrectomy/instrumentation/*methods
MH  - Operative Time
MH  - Surgical Instruments
MH  - Treatment Outcome
MH  - Umbilicus/surgery
EDAT- 2011/04/05 06:00
MHDA- 2013/04/24 06:00
CRDT- 2011/04/05 06:00
PHST- 2010/11/16 00:00 [received]
PHST- 2011/03/01 00:00 [accepted]
PHST- 2011/04/05 06:00 [entrez]
PHST- 2011/04/05 06:00 [pubmed]
PHST- 2013/04/24 06:00 [medline]
AID - 10.1007/s00345-011-0670-7 [doi]
PST - ppublish
SO  - World J Urol. 2012 Oct;30(5):613-8. doi: 10.1007/s00345-011-0670-7. Epub 2011 Apr
      2.


PMID- 21461713
OWN - NLM
STAT- MEDLINE
DCOM- 20120316
LR  - 20211203
IS  - 2629-3277 (Electronic)
IS  - 2629-3277 (Linking)
VI  - 7
IP  - 4
DP  - 2011 Nov
TI  - Do we still need human embryonic stem cells for stem cell-based therapies?
      Epistemic and ethical aspects.
PG  - 761-74
LID - 10.1007/s12015-011-9257-3 [doi]
AB  - While scientific community disagrees about similarities and differences between
      human embryonic stem (hES) cells and human induced pluripotent stem (hiPS) cells,
      some politicians embrace translational hiPS cell research as a replacement for
      translational hES cell research. We examine the ethical relevance of the main
      differences between hES and hiPS cell-based therapies and discuss whether, given 
      the current state of knowledge, certain differences are essential. We discuss
      whether well-founded preferences can be made in hypothetical scenarios with
      varying levels of patient safety, treatment efficacy, treatment accessibility and
      ethical controversy.
FAU - Hug, Kristina
AU  - Hug K
AD  - Department of Medical Ethics, Lund University, Lund, Sweden.
      Kristina.Hug@med.lu.se
FAU - Hermeren, Goran
AU  - Hermeren G
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Stem Cell Rev Rep
JT  - Stem cell reviews and reports
JID - 101752767
SB  - IM
MH  - Embryonic Stem Cells/*cytology/transplantation
MH  - Humans
MH  - Induced Pluripotent Stem Cells/cytology
MH  - Stem Cell Research/*ethics
MH  - Stem Cell Transplantation/ethics
MH  - Translational Research, Biomedical/*ethics
EDAT- 2011/04/05 06:00
MHDA- 2012/03/17 06:00
CRDT- 2011/04/05 06:00
PHST- 2011/04/05 06:00 [entrez]
PHST- 2011/04/05 06:00 [pubmed]
PHST- 2012/03/17 06:00 [medline]
AID - 10.1007/s12015-011-9257-3 [doi]
PST - ppublish
SO  - Stem Cell Rev Rep. 2011 Nov;7(4):761-74. doi: 10.1007/s12015-011-9257-3.


PMID- 21461203
OWN - NLM
STAT- MEDLINE
DCOM- 20110523
LR  - 20211020
IS  - 0008-5286 (Print)
IS  - 0008-5286 (Linking)
VI  - 52
IP  - 1
DP  - 2011 Jan
TI  - An ethicist's commentary on political correctness versus farm animal welfare.
PG  - 13-6
FAU - Rollin, Bernard E
AU  - Rollin BE
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Vet J
JT  - The Canadian veterinary journal = La revue veterinaire canadienne
JID - 0004653
SB  - IM
MH  - Animal Welfare/*ethics
MH  - Animals
MH  - *Culture
MH  - Humans
MH  - *Politics
MH  - Veterinary Medicine/*ethics
PMC - PMC3003570
EDAT- 2011/04/05 06:00
MHDA- 2011/05/24 06:00
CRDT- 2011/04/05 06:00
PHST- 2011/04/05 06:00 [entrez]
PHST- 2011/04/05 06:00 [pubmed]
PHST- 2011/05/24 06:00 [medline]
PST - ppublish
SO  - Can Vet J. 2011 Jan;52(1):13-6.


PMID- 21460742
OWN - NLM
STAT- MEDLINE
DCOM- 20111019
LR  - 20110805
IS  - 1529-8809 (Electronic)
IS  - 0022-5282 (Linking)
VI  - 71
IP  - 1
DP  - 2011 Jul
TI  - Decompressive craniectomy for diffuse cerebral swelling after trauma: long-term
      outcome and ethical considerations.
PG  - 128-32
LID - 10.1097/TA.0b013e3182117b6c [doi]
AB  - BACKGROUND: There is currently much interest in the use of decompressive for the 
      management of diffuse cerebral swelling after trauma. Although the use of the
      procedure may improve survival, some of those survivors may be left severely
      disabled. The aim of this study was to see whether severe disability can be
      predicted and discuss the difficult ethical issue that this raises. METHODS: This
      was a retrospective cohort subgroup analysis of those patients with severe head
      injury in Western Australia between 2004 and 2008 who had had a decompressive
      craniectomy for intractably raised intracranial pressure despite maximal medical 
      management. RESULTS: Among a total of 1,786 adult neurotrauma patients admitted
      between 2004 and 2008, 74 patients required a bifrontal decompressive craniectomy
      for intractably raised intracranial pressure. After the application of
      Corticosteroid Randomization After Significant Head Injury (CRASH) trial
      collaborators' prediction model, predicted and observed outcomes were compared.
      The mean timing and median timing of surgery were 42 hours and 30 hours after
      hospital admission, respectively. The timing of decompressive craniectomy was
      inversely correlated to the severity of the head injury (Spearman's correlation
      coefficient = -0.251, p = 0.031). At 18-month follow-up, 16 patients were
      deceased, 3 were in a persistent vegetative state, and 10 were severely disabled.
      In contrast to these unfavorable outcomes, 35 patients had a good outcome and 10 
      were moderately disabled at 18 months. The discrimination of the CRASH prediction
      model was excellent (area under receiver-operating characteristic curve, 0.905;
      95% confidence interval, 0.829-0.982; p = 0.001). CONCLUSION: Our data provide
      some evidence that the CRASH prediction model may help clinicians and families to
      make informed decision about the benefits and risks of decompressive craniectomy 
      for diffuse cerebral swelling.
FAU - Honeybul, Stephen
AU  - Honeybul S
AD  - Department of Neurosurgery, Sir Charles Gairdner Hospital, Perth, Western
      Australia. stephen.honeybul@health.wa.gov.au
FAU - Ho, Kwok M
AU  - Ho KM
FAU - Lind, Christopher R P
AU  - Lind CR
FAU - Gillett, Grant R
AU  - Gillett GR
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - J Trauma
JT  - The Journal of trauma
JID - 0376373
SB  - IM
CIN - J Trauma. 2011 Jul;71(1):266-7; author reply 267. PMID: 21818043
MH  - Adolescent
MH  - Adult
MH  - Brain Edema/epidemiology/etiology/*surgery
MH  - Confidence Intervals
MH  - Craniocerebral Trauma/*complications/diagnosis/surgery
MH  - Craniotomy/*ethics
MH  - Decompression, Surgical/ethics/*methods
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Prognosis
MH  - ROC Curve
MH  - Retrospective Studies
MH  - Time Factors
MH  - Trauma Severity Indices
MH  - Western Australia/epidemiology
MH  - Young Adult
EDAT- 2011/04/05 06:00
MHDA- 2011/10/20 06:00
CRDT- 2011/04/05 06:00
PHST- 2011/04/05 06:00 [entrez]
PHST- 2011/04/05 06:00 [pubmed]
PHST- 2011/10/20 06:00 [medline]
AID - 10.1097/TA.0b013e3182117b6c [doi]
PST - ppublish
SO  - J Trauma. 2011 Jul;71(1):128-32. doi: 10.1097/TA.0b013e3182117b6c.


PMID- 21460643
OWN - NLM
STAT- MEDLINE
DCOM- 20110808
LR  - 20211020
IS  - 1473-6578 (Electronic)
IS  - 0951-7367 (Linking)
VI  - 24
IP  - 3
DP  - 2011 May
TI  - Ethical issues in mental health research: the case for community engagement.
PG  - 208-14
LID - 10.1097/YCO.0b013e3283459422 [doi]
AB  - PURPOSE OF REVIEW: To describe community-engaged research (CEnR) and how it may
      improve the quality of a research study while addressing ethical concerns that
      communities may have with mental health and substance abuse research. This
      article includes a review of the literature as well as recommendations from an
      expert panel convened with funding from the US National Institute of Mental
      Health. RECENT FINDINGS: CEnR represents a broad spectrum of practices, including
      representation on institutional ethics committees, attitude research with
      individuals from the study population, engaging community advisory boards,
      forming research partnerships with community organizations, and including
      community members as co-investigators. SUMMARY: CEnR poses some challenges; for
      example, it requires funding and training for researchers and community members. 
      However, it offers many benefits to researchers and communities, and some form of
      CEnR is appropriate and feasible in nearly every study involving human
      participants.
FAU - Dubois, James M
AU  - Dubois JM
AD  - Gnaegi Center for Healthcare Ethics, Salus 5th floor, Saint Louis University,
      3545 Lafayette Avenue, St Louis, MO 63104, USA. duboisjm@slu.edu
FAU - Bailey-Burch, Brendolyn
AU  - Bailey-Burch B
FAU - Bustillos, Dan
AU  - Bustillos D
FAU - Campbell, Jean
AU  - Campbell J
FAU - Cottler, Linda
AU  - Cottler L
FAU - Fisher, Celia B
AU  - Fisher CB
FAU - Hadley, Whitney B
AU  - Hadley WB
FAU - Hoop, Jinger G
AU  - Hoop JG
FAU - Roberts, Laura
AU  - Roberts L
FAU - Salter, Erica K
AU  - Salter EK
FAU - Sieber, Joan E
AU  - Sieber JE
FAU - Stevenson, Richard D
AU  - Stevenson RD
LA  - eng
GR  - R13 MH079690/MH/NIMH NIH HHS/United States
GR  - UL1 RR024992/RR/NCRR NIH HHS/United States
GR  - UL1 TR000448/TR/NCATS NIH HHS/United States
GR  - 1R13MH079690/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United States
TA  - Curr Opin Psychiatry
JT  - Current opinion in psychiatry
JID - 8809880
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Ethics Committees, Research
MH  - *Ethics, Research
MH  - Humans
MH  - *Mental Disorders
MH  - Mental Health
MH  - Residence Characteristics
PMC - PMC3528105
MID - NIHMS419279
EDAT- 2011/04/05 06:00
MHDA- 2011/08/09 06:00
CRDT- 2011/04/05 06:00
PHST- 2011/04/05 06:00 [entrez]
PHST- 2011/04/05 06:00 [pubmed]
PHST- 2011/08/09 06:00 [medline]
AID - 10.1097/YCO.0b013e3283459422 [doi]
AID - 00001504-201105000-00007 [pii]
PST - ppublish
SO  - Curr Opin Psychiatry. 2011 May;24(3):208-14. doi: 10.1097/YCO.0b013e3283459422.


PMID- 21460642
OWN - NLM
STAT- MEDLINE
DCOM- 20110808
LR  - 20110404
IS  - 1473-6578 (Electronic)
IS  - 0951-7367 (Linking)
VI  - 24
IP  - 3
DP  - 2011 May
TI  - Ethical, legal and social issues related to alcohol and drug research.
PG  - 181-5
LID - 10.1097/YCO.0b013e32834593bc [doi]
AB  - PURPOSE OF REVIEW: To present some highlights and comments about ethical, legal
      and social issues related to alcohol and drug research. RECENT FINDINGS: Alcohol 
      and drug research has a lack of scientific production related to ethical, legal
      and social issues. Many papers simply describe summarily the informed consent
      process and other related issues. SUMMARY: Informed consent process is one of the
      most important issues in research ethics. Obtaining a valid consent from a
      prospective research participant is always a challenge. We present many different
      ways to reach ethical, legal and social adequacy related to the informed consent 
      process.
FAU - Goldim, Jose R
AU  - Goldim JR
AD  - Bioethics Division, Hospital de Clinicas de Porto Alegre, Brazil.
      jgoldim@hcpa.ufrgs.br
FAU - Fernandes, Marcia S
AU  - Fernandes MS
FAU - Pechansky, Flavio
AU  - Pechansky F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Curr Opin Psychiatry
JT  - Current opinion in psychiatry
JID - 8809880
SB  - IM
MH  - Biomedical Research/*ethics/legislation & jurisprudence
MH  - *Ethics, Research
MH  - Humans
MH  - Informed Consent/*ethics/legislation & jurisprudence
MH  - *Substance-Related Disorders
EDAT- 2011/04/05 06:00
MHDA- 2011/08/09 06:00
CRDT- 2011/04/05 06:00
PHST- 2011/04/05 06:00 [entrez]
PHST- 2011/04/05 06:00 [pubmed]
PHST- 2011/08/09 06:00 [medline]
AID - 10.1097/YCO.0b013e32834593bc [doi]
AID - 00001504-201105000-00002 [pii]
PST - ppublish
SO  - Curr Opin Psychiatry. 2011 May;24(3):181-5. doi: 10.1097/YCO.0b013e32834593bc.


PMID- 21460592
OWN - NLM
STAT- MEDLINE
DCOM- 20110607
LR  - 20110404
IS  - 1556-2646 (Print)
IS  - 1556-2646 (Linking)
VI  - 6
IP  - 1
DP  - 2011 Mar
TI  - The influence of prior experience on research participants' perspectives: a
      research agenda.
PG  - 83-4
LID - 10.1525/jer.2011.6.1.83 [doi]
AB  - A small preliminary study of 15 teachers who had participated in education
      research in England examined the effects of prior experience as research
      participants on why they participated and how they perceived the methodology and 
      ethics of the research. Nine participants were research novices, while six were
      research experienced. The latter group were found to be more perceptive and
      critical of the ethics of the research and focused on the research purposes and
      adequacy of the methods. The findings are discussed in the context of how a
      future research agenda might be informed by an understanding of participants'
      prior research experience. This study has particular relevance to research where 
      participants are likely to have had prior experience or contact as participants
      (e.g., subject pools, participants in longitudinal studies).
FAU - Mitchell, Nick
AU  - Mitchell N
AD  - Leeds Metropolitan University, Leads, UK. N.N.Mitchell@leeds-met.ac.uk
FAU - Hobson, Andrew J
AU  - Hobson AJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - *Education
MH  - *Ethics, Research
MH  - Humans
MH  - Research Subjects/*psychology
EDAT- 2011/04/05 06:00
MHDA- 2011/06/08 06:00
CRDT- 2011/04/05 06:00
PHST- 2011/04/05 06:00 [entrez]
PHST- 2011/04/05 06:00 [pubmed]
PHST- 2011/06/08 06:00 [medline]
AID - 10.1525/jer.2011.6.1.83 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2011 Mar;6(1):83-4. doi: 10.1525/jer.2011.6.1.83.


PMID- 21460591
OWN - NLM
STAT- MEDLINE
DCOM- 20110607
LR  - 20110404
IS  - 1556-2646 (Print)
IS  - 1556-2646 (Linking)
VI  - 6
IP  - 1
DP  - 2011 Mar
TI  - Strengthening the educational value of undergraduate participation in research as
      part of a psychology department subject pool.
PG  - 75-82
LID - 10.1525/jer.2011.6.1.75 [doi]
AB  - Participating in research must be an educational experience for students in order
      to ethically justify its inclusion as a requirement in college courses.
      Introductory Psychology students (N = 280) completed a written class assignment
      describing their research participation as a means to enhance this educational
      mission. Approximately half of students spontaneously mentioned something
      positive about the significance of the research or what they learned, with the
      remainder providing neutral, mixed, or negative comments. Students could
      articulate clearly and knowledgeably about the research in which they had
      participated. Such an assignment is an effective means to foster an understanding
      of the science of psychology.
FAU - Moyer, Anne
AU  - Moyer A
AD  - Department of Psychology, Stony Brook University, Stony Brook, NY 11974-2500,
      USA. anne.moyer@sunysb.edu
FAU - Franklin, Nancy
AU  - Franklin N
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Biomedical Research
MH  - Female
MH  - Humans
MH  - Male
MH  - Psychology/*education
MH  - Students/*psychology
MH  - Young Adult
EDAT- 2011/04/05 06:00
MHDA- 2011/06/08 06:00
CRDT- 2011/04/05 06:00
PHST- 2011/04/05 06:00 [entrez]
PHST- 2011/04/05 06:00 [pubmed]
PHST- 2011/06/08 06:00 [medline]
AID - 10.1525/jer.2011.6.1.75 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2011 Mar;6(1):75-82. doi: 10.1525/jer.2011.6.1.75.


PMID- 21460589
OWN - NLM
STAT- MEDLINE
DCOM- 20110607
LR  - 20211020
IS  - 1556-2646 (Print)
IS  - 1556-2646 (Linking)
VI  - 6
IP  - 1
DP  - 2011 Mar
TI  - Measuring how people view biomedical research: Reliability and validity analysis 
      of the Research Attitudes Questionnaire.
PG  - 63-8
LID - 10.1525/jer.2011.6.1.63 [doi]
AB  - With increasing numbers of studies on research ethics and a need to improve the
      recruitment of research subjects, the ability to measure attitudes toward
      biomedical research has become important. The Research Attitudes Questionnaire is
      a significant predictor of the public's attitudes toward and willingness to
      participate in research, yet limited data are available on its psychometric
      properties. This study establishes the scale's internal consistency and
      dimensionality using a large Internet-based sample from the United States. One
      item was removed due to a poor item-total correlation, and three additional items
      were removed which formed a reverse-wording measurement artifact factor. With
      improved internal consistency and dimensionality, the seven-item version has the 
      advantages of shorter administration time and improved psychometric properties.
FAU - Rubright, Jonathan D
AU  - Rubright JD
AD  - University of Delaware.
FAU - Cary, Mark S
AU  - Cary MS
FAU - Karlawish, Jason H
AU  - Karlawish JH
FAU - Kim, Scott Y H
AU  - Kim SY
LA  - eng
GR  - P30 AG010124/AG/NIA NIH HHS/United States
GR  - P30-AG-10124/AG/NIA NIH HHS/United States
GR  - R01 MH071643/MH/NIMH NIH HHS/United States
GR  - R01-MH071643/MH/NIMH NIH HHS/United States
GR  - R01 MH071643-01A2/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Aged
MH  - *Attitude
MH  - *Biomedical Research
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Psychometrics
MH  - Reproducibility of Results
MH  - *Surveys and Questionnaires
PMC - PMC3253733
MID - NIHMS345745
EDAT- 2011/04/05 06:00
MHDA- 2011/06/08 06:00
CRDT- 2011/04/05 06:00
PHST- 2011/04/05 06:00 [entrez]
PHST- 2011/04/05 06:00 [pubmed]
PHST- 2011/06/08 06:00 [medline]
AID - 10.1525/jer.2011.6.1.63 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2011 Mar;6(1):63-8. doi: 10.1525/jer.2011.6.1.63.


PMID- 21460587
OWN - NLM
STAT- MEDLINE
DCOM- 20110607
LR  - 20110404
IS  - 1556-2646 (Print)
IS  - 1556-2646 (Linking)
VI  - 6
IP  - 1
DP  - 2011 Mar
TI  - Ethical behaviors of latin american psychotherapy researchers.
PG  - 51-4
LID - 10.1525/jer.2011.6.1.51 [doi]
AB  - The ethical practices of psychotherapy researchers in Latin America were surveyed
      online. Of the 114 psychotherapy researchers to whom the survey was sent, 76
      responded (67% response rate). Seventy-seven percent of the respondents had not
      received formal training in research ethics, yet 84% indicated that formal
      training is useful for the prevention of scientific misbehavior. Researchers
      admitted to various ethically questionable practices, the most common of which
      were related to authorship. None reported having fabricated or falsified data.
      The need for adequate training and evaluation of research projects is addressed.
FAU - Roussos, Andres J
AU  - Roussos AJ
AD  - Universidad de Belgrano, Zabala, CABA, Argentina.
      andres.roussos@comunidad.ub.edu.ar
FAU - Braun, Malena
AU  - Braun M
FAU - Duarte, Adela Leibovich de
AU  - Duarte AL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Humans
MH  - Latin America
MH  - Professional Misconduct/*ethics
MH  - Psychotherapy/*ethics
EDAT- 2011/04/05 06:00
MHDA- 2011/06/08 06:00
CRDT- 2011/04/05 06:00
PHST- 2011/04/05 06:00 [entrez]
PHST- 2011/04/05 06:00 [pubmed]
PHST- 2011/06/08 06:00 [medline]
AID - 10.1525/jer.2011.6.1.51 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2011 Mar;6(1):51-4. doi: 10.1525/jer.2011.6.1.51.


PMID- 21460584
OWN - NLM
STAT- MEDLINE
DCOM- 20110607
LR  - 20211020
IS  - 1556-2646 (Print)
IS  - 1556-2646 (Linking)
VI  - 6
IP  - 1
DP  - 2011 Mar
TI  - Consequences identification in forecasting and ethical decision-making.
PG  - 25-32
LID - 10.1525/jer.2011.6.1.25 [doi]
AB  - Forecasting involves predicting outcomes based on observations of the situation
      at hand. We examined the impact of the number and types of consequences
      considered on the quality of ethical decision-making. Undergraduates role-played 
      several ethical problems in which they forecast potential outcomes and made
      decisions. Performance pressure (difficult demands placed on the situation) and
      interpersonal conflict (clashes among people in the problem situation) were
      manipulated within each problem scenario. The results indicated that the
      identification of potential consequences was positively associated with both
      higher quality forecasts and more ethical decisions. Neither performance pressure
      nor interpersonal conflict affected the quality of forecasts or decisions.
      Theoretical and practical implications of these findings and the use of this
      research approach are discussed.
FAU - Stenmark, Cheryl K
AU  - Stenmark CK
AD  - Department of Psychology, Sociology, and Social Work, Angelo State University,
      ASU Station #10907, San Angelo, TX 76909-0907, USA. cherylstenmark@gmail.com
FAU - Antes, Alison L
AU  - Antes AL
FAU - Thiel, Chase E
AU  - Thiel CE
FAU - Caughron, Jared J
AU  - Caughron JJ
FAU - Wang, Xiaoqian
AU  - Wang X
FAU - Mumford, Michael D
AU  - Mumford MD
LA  - eng
GR  - R01 NR010341/NR/NINR NIH HHS/United States
GR  - R01 NR010341-02/NR/NINR NIH HHS/United States
GR  - 5R01NR010341-02/NR/NINR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Conflict, Psychological
MH  - Decision Making/*ethics
MH  - Female
MH  - *Forecasting
MH  - Humans
MH  - Interpersonal Relations
MH  - Male
MH  - Motivation
MH  - Outcome Assessment, Health Care
MH  - Stress, Psychological
MH  - Young Adult
PMC - PMC4470570
MID - NIHMS345733
EDAT- 2011/04/05 06:00
MHDA- 2011/06/08 06:00
CRDT- 2011/04/05 06:00
PHST- 2011/04/05 06:00 [entrez]
PHST- 2011/04/05 06:00 [pubmed]
PHST- 2011/06/08 06:00 [medline]
AID - 10.1525/jer.2011.6.1.25 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2011 Mar;6(1):25-32. doi: 10.1525/jer.2011.6.1.25.


PMID- 21460583
OWN - NLM
STAT- MEDLINE
DCOM- 20110607
LR  - 20211020
IS  - 1556-2646 (Print)
IS  - 1556-2646 (Linking)
VI  - 6
IP  - 1
DP  - 2011 Mar
TI  - A delphi study to establish important aspects of ethics review.
PG  - 21-4
LID - 10.1525/jer.2011.6.1.21 [doi]
AB  - Little research has been done to examine the cost-effectiveness of REC review, or
      the components of review that make the greatest contributions to the protection
      of human subjects. We describe a process used to obtain consensus on the
      important categories and outcomes of REC review using the Delphi method and an
      array of stakeholders in a limited domain of research (biomedical). Study
      participants recruited from the University of Michigan Medical School's RECs, REC
      council, and principal investigators identified the following six categories as
      being the most important aspects of REC review: (1) A favorable risk/benefit
      ratio; (2) minimization of risk to subjects; (3) clarity of consent; (4)
      protection of vulnerable populations; (5) protection of privacy and
      confidentiality; and (6) review time. We believe that this kind of information
      can be used to assist in the development of a metric to assess the effectiveness 
      and efficiency of REC review in the various research domains.
FAU - Geisser, Michael E
AU  - Geisser ME
AD  - University of Michigan Health System, The Spine Program 325 E. Eisenhower
      Parkway, Ann Arbor, MI 48108, USA. mgeisser@umich.edu
FAU - Alschuler, Kevin N
AU  - Alschuler KN
FAU - Hutchinson, Raymond
AU  - Hutchinson R
LA  - eng
GR  - UL1 RR024986/RR/NCRR NIH HHS/United States
GR  - UL1 RR024986-02/RR/NCRR NIH HHS/United States
GR  - UL1RR024986/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Confidentiality
MH  - Delphi Technique
MH  - *Ethics Committees
MH  - Informed Consent
MH  - Michigan
MH  - Risk Assessment
MH  - Schools, Medical
MH  - Surveys and Questionnaires
MH  - Vulnerable Populations
PMC - PMC3253534
MID - NIHMS345728
EDAT- 2011/04/05 06:00
MHDA- 2011/06/08 06:00
CRDT- 2011/04/05 06:00
PHST- 2011/04/05 06:00 [entrez]
PHST- 2011/04/05 06:00 [pubmed]
PHST- 2011/06/08 06:00 [medline]
AID - 10.1525/jer.2011.6.1.21 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2011 Mar;6(1):21-4. doi: 10.1525/jer.2011.6.1.21.


PMID- 21460030
OWN - NLM
STAT- MEDLINE
DCOM- 20110902
LR  - 20220318
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 260
IP  - 1
DP  - 2011 Jul
TI  - Cartilage quality assessment by using glycosaminoglycan chemical exchange
      saturation transfer and (23)Na MR imaging at 7 T.
PG  - 257-64
LID - 10.1148/radiol.11101841 [doi]
AB  - PURPOSE: To compare a glycosaminoglycan chemical exchange saturation transfer
      (gagCEST) imaging method, which enables sampling of the water signal as a
      function of the presaturation offset (z-spectrum) at 13 points in clinically
      feasible imaging times, with sodium 23 ((23)Na) magnetic resonance (MR) imaging
      in patients after cartilage repair surgery (matrix-associated autologous
      chondrocyte transplantation and microfracture therapy). MATERIALS AND METHODS:
      One female patient (67.3 years), and 11 male patients (median age, 28.8 years;
      interquartile range [IQR], 24.6-32.3 years) were examined with a 7-T whole-body
      system, with approval of the local ethics committee after written informed
      consent was obtained. A modified three-dimensional gradient-echo sequence and a
      28-channel knee coil were used for gagCEST imaging. (23)Na imaging was performed 
      with a circularly polarized knee coil by using a modified gradient-echo sequence.
      Statistical analysis of differences and Spearman correlation were applied.
      RESULTS: The median of asymmetries in gagCEST z-spectra summed over all offsets
      from 0 to 1.3 ppm was 7.99% (IQR, 6.33%-8.79%) in native cartilage and 5.13%
      (IQR, 2.64%-6.34%) in repair tissue. A strong correlation (r = 0.701; 95%
      confidence interval: 0.21, 0.91) was found between ratios of signal intensity
      from native cartilage to signal intensity from repair tissue obtained with
      gagCEST or (23)Na imaging. The median of dimensionless ratios between native
      cartilage and repair tissue was 1.28 (IQR, 1.20-1.58) for gagCEST and 1.26 (IQR, 
      1.21-1.48) for (23)Na MR imaging. CONCLUSION: The high correlation between the
      introduced gagCEST method and (23)Na imaging implies that gagCEST is a
      potentially useful biomarker for glycosaminoglycans.
FAU - Schmitt, Benjamin
AU  - Schmitt B
AD  - Division of Medical Physics in Radiology, German Cancer Research Center, Im
      Neuenheimer Feld 280, D-69120 Heidelberg, Germany. b.schmitt@dkfz-heidelberg.de
FAU - Zbyn, Stefan
AU  - Zbyn S
FAU - Stelzeneder, David
AU  - Stelzeneder D
FAU - Jellus, Vladimir
AU  - Jellus V
FAU - Paul, Dominik
AU  - Paul D
FAU - Lauer, Lars
AU  - Lauer L
FAU - Bachert, Peter
AU  - Bachert P
FAU - Trattnig, Siegfried
AU  - Trattnig S
LA  - eng
GR  - I 652/FWF_/Austrian Science Fund FWF/Austria
GR  - I 690/FWF_/Austrian Science Fund FWF/Austria
PT  - Journal Article
DEP - 20110401
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - 0 (Glycosaminoglycans)
RN  - 0 (Sodium Isotopes)
SB  - IM
MH  - Adult
MH  - Arthroplasty, Subchondral
MH  - Cartilage, Articular/*metabolism/*pathology
MH  - Contrast Media/pharmacokinetics
MH  - Female
MH  - Glycosaminoglycans/*metabolism
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Sodium Isotopes/pharmacokinetics
MH  - Young Adult
EDAT- 2011/04/05 06:00
MHDA- 2011/09/03 06:00
CRDT- 2011/04/05 06:00
PHST- 2011/04/05 06:00 [entrez]
PHST- 2011/04/05 06:00 [pubmed]
PHST- 2011/09/03 06:00 [medline]
AID - radiol.11101841 [pii]
AID - 10.1148/radiol.11101841 [doi]
PST - ppublish
SO  - Radiology. 2011 Jul;260(1):257-64. doi: 10.1148/radiol.11101841. Epub 2011 Apr 1.


PMID- 21459532
OWN - NLM
STAT- MEDLINE
DCOM- 20121024
LR  - 20220309
IS  - 1872-7727 (Electronic)
IS  - 0720-048X (Linking)
VI  - 81
IP  - 7
DP  - 2012 Jul
TI  - 1.5T conventional MR-guided iodine-125 interstitial implants for hepatocellular
      carcinoma: feasibility and preliminary clinical experience.
PG  - 1420-5
LID - 10.1016/j.ejrad.2011.03.043 [doi]
AB  - PURPOSE: To evaluate the feasibility and therapeutic efficacy of 1.5 T
      conventional MR-guided percutaneous interstitial implantation of I-125
      radioactive seeds in patients with hepatocellular carcinoma (HCC). MATERIALS AND 
      METHODS: The institutional ethics committee approved this study. After imformed
      consent was obtained, twenty-three patients suffering from a total of 65 HCC
      lesions were treated with I-125 seed permanent interstitial implantation under
      the guidance of a 1.5T conventional magnetic resonance imaging (MRI) system. The 
      FSE T2WI, T1 FSPGR, FIESTA 2D, 3D Dyn T1WI sequences were used to guide an 18 G
      MR-compatible needle inserted into the lesions to introduce the I-125 seeds. The 
      response evaluation criteria in solid tumors (RECIST) were used to evaluate the
      curative effect. RESULTS: The needle and I-125 seed were seen clearly on MRI
      images. The final dose delivered to total decay was 173.46 +/- 32.44 Gy (range,
      110-270 Gy) as calculated by postoperative TPS. The complete response (CR) was
      seen in 22 lesions (33.8%), partial response (PR) in 24 lesions (36.9%), stable
      disease (SD) in 9 lesions (13.8%), and progressive disease (PD) in 10 lesions
      (15.4%). The post-operative alpha-fetoprotein (AFP) was decreased (t = 3.117, P =
      0.005<0.05). Two patients were observed a small area of subcapsular bleeding that
      did not lead to any symptoms or clinical sequelae. CONCLUSION: MR-guided I-125
      implantation for HCC is technically feasible and effective.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Lin, Zheng-Yu
AU  - Lin ZY
AD  - The Department of Radiology, First Affiliated Hospital of Fujian Medical
      University, 20 Chazhong Road, Fuzhou 350005, China. linsinlan@yahoo.com.cn
FAU - Lin, Jun
AU  - Lin J
FAU - Lin, Cong
AU  - Lin C
FAU - Li, Yin-Guan
AU  - Li YG
FAU - Chen, Shao-Ming
AU  - Chen SM
FAU - Hu, Jian-Ping
AU  - Hu JP
FAU - Hu, Rui
AU  - Hu R
FAU - Chen, Jin
AU  - Chen J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110403
PL  - Ireland
TA  - Eur J Radiol
JT  - European journal of radiology
JID - 8106411
RN  - 0 (Iodine Radioisotopes)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brachytherapy/*methods
MH  - Carcinoma, Hepatocellular/*radiotherapy
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Iodine Radioisotopes/administration & dosage/*therapeutic use
MH  - Liver Neoplasms/*radiotherapy
MH  - Magnetic Resonance Imaging, Interventional/*methods
MH  - Male
MH  - Middle Aged
MH  - Radiotherapy Planning, Computer-Assisted
MH  - Treatment Outcome
EDAT- 2011/04/05 06:00
MHDA- 2012/10/25 06:00
CRDT- 2011/04/05 06:00
PHST- 2011/01/06 00:00 [received]
PHST- 2011/03/05 00:00 [revised]
PHST- 2011/03/11 00:00 [accepted]
PHST- 2011/04/05 06:00 [entrez]
PHST- 2011/04/05 06:00 [pubmed]
PHST- 2012/10/25 06:00 [medline]
AID - S0720-048X(11)00313-5 [pii]
AID - 10.1016/j.ejrad.2011.03.043 [doi]
PST - ppublish
SO  - Eur J Radiol. 2012 Jul;81(7):1420-5. doi: 10.1016/j.ejrad.2011.03.043. Epub 2011 
      Apr 3.


PMID- 21459500
OWN - NLM
STAT- MEDLINE
DCOM- 20120515
LR  - 20220309
IS  - 1532-3099 (Electronic)
IS  - 0266-6138 (Linking)
VI  - 28
IP  - 1
DP  - 2012 Feb
TI  - Views of midwives about ethical aspects of participation in placental perfusion
      studies.
PG  - 131-7
LID - 10.1016/j.midw.2011.02.003 [doi]
AB  - BACKGROUND: Little is known regarding the role of the midwife in recruiting
      mothers to participate in scientific research. OBJECTIVE: To describe ethical
      aspects of participation of midwives in placental perfusion studies. DESIGN:
      Qualitative study involving thematic interviews and thematic content analysis.
      SETTING: Two university hospitals in Finland in 2008-2009. PARTICIPANTS: Midwives
      (n=20) who had been involved in recruiting mothers for a placental perfusion
      study. FINDINGS: Midwives felt that the situation, when inviting the mothers to
      donate their placentas, was restless and hasty because of the considerable number
      of tasks required during a birth. For recruitment, they explained how they tried 
      their best to find a quiet opportunity to provide information about the placental
      perfusion study, so that the mother could take her time reading the written
      information. During a birth, it was difficult to give information to the mother
      in such a way that she would truly understand. Information for the mother was
      planned to be provided in an equal, dialogic conversation, with the subject of
      research introduced by the midwife. Placental perfusion studies as carried out in
      this setting were not seen to have any risks for the mothers, and midwives were
      under less strain in this study than in other medical research projects. The
      midwives considered it normal to use placentas in scientific research, and did
      not see any associated ethical problems. In their opinion, the use of placentas
      was acceptable and even desirable, provided that the mother was informed about
      the research and gave voluntary informed consent. CONCLUSIONS AND IMPLICATIONS
      FOR PRACTISE: Recruitment must be taken into account in management of the ward,
      and should be planned so that no recruitment is undertaken during medical
      procedures. Midwives need more education about the research including the
      important aspects of the creation of general knowledge about substances which may
      harm the fetus. Dialogue is needed between the mother and the midwife to ensure
      genuine informed consent.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Halkoaho, Arja
AU  - Halkoaho A
AD  - Department of Nursing Science, Faculty of Health Sciences, University of Eastern 
      Finland, 70211 Kuopio, Finland. arja.halkoaho@kuh.fi
FAU - Kirsi Vahakangas
AU  - Kirsi Vahakangas
FAU - Haggman-Laitila, Arja
AU  - Haggman-Laitila A
FAU - Pietila, Anna-Maija
AU  - Pietila AM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110402
PL  - Scotland
TA  - Midwifery
JT  - Midwifery
JID - 8510930
MH  - Adult
MH  - *Ethics, Nursing
MH  - Female
MH  - Finland
MH  - Human Experimentation/ethics
MH  - Humans
MH  - Informed Consent/ethics
MH  - Midwifery/*ethics/methods
MH  - Mothers/education
MH  - Nurse-Patient Relations/*ethics
MH  - Patient Selection/*ethics
MH  - Perfusion/*ethics
MH  - Placenta/*blood supply
MH  - Pregnancy
MH  - Tissue Donors/ethics
MH  - Tissue and Organ Procurement/*ethics
MH  - Young Adult
EDAT- 2011/04/05 06:00
MHDA- 2012/05/16 06:00
CRDT- 2011/04/05 06:00
PHST- 2010/11/11 00:00 [received]
PHST- 2011/01/12 00:00 [revised]
PHST- 2011/02/12 00:00 [accepted]
PHST- 2011/04/05 06:00 [entrez]
PHST- 2011/04/05 06:00 [pubmed]
PHST- 2012/05/16 06:00 [medline]
AID - S0266-6138(11)00012-X [pii]
AID - 10.1016/j.midw.2011.02.003 [doi]
PST - ppublish
SO  - Midwifery. 2012 Feb;28(1):131-7. doi: 10.1016/j.midw.2011.02.003. Epub 2011 Apr
      2.


PMID- 21459225
OWN - NLM
STAT- MEDLINE
DCOM- 20110606
LR  - 20110404
IS  - 1549-4713 (Electronic)
IS  - 0161-6420 (Linking)
VI  - 118
IP  - 4
DP  - 2011 Apr
TI  - Ethical problems in invasive clinical research.
PG  - 787-8; author reply 788-9
LID - 10.1016/j.ophtha.2011.01.020 [doi]
FAU - Grzybowski, Andrzej
AU  - Grzybowski A
FAU - Sade, Robert
AU  - Sade R
FAU - Loff, Bebe
AU  - Loff B
LA  - eng
PT  - Comment
PT  - Letter
PL  - United States
TA  - Ophthalmology
JT  - Ophthalmology
JID - 7802443
SB  - IM
CON - Ophthalmology. 2010 Feb;117(2):259-66. PMID: 19969367
MH  - Biomedical Research
MH  - Blood Pressure/physiology
MH  - Cerebrospinal Fluid Pressure/*physiology
MH  - *Ethics, Medical
MH  - Glaucoma, Open-Angle/etiology/*physiopathology
MH  - Humans
MH  - Intracranial Hypotension/*physiopathology
MH  - Intraocular Pressure/*physiology
MH  - Optic Nerve Diseases/etiology/*physiopathology
MH  - Spinal Puncture
MH  - Visual Fields/physiology
EDAT- 2011/04/05 06:00
MHDA- 2011/06/07 06:00
CRDT- 2011/04/05 06:00
PHST- 2010/07/09 00:00 [received]
PHST- 2011/01/06 00:00 [accepted]
PHST- 2011/04/05 06:00 [entrez]
PHST- 2011/04/05 06:00 [pubmed]
PHST- 2011/06/07 06:00 [medline]
AID - S0161-6420(11)00047-9 [pii]
AID - 10.1016/j.ophtha.2011.01.020 [doi]
PST - ppublish
SO  - Ophthalmology. 2011 Apr;118(4):787-8; author reply 788-9. doi:
      10.1016/j.ophtha.2011.01.020.


PMID- 21459109
OWN - NLM
STAT- MEDLINE
DCOM- 20120503
LR  - 20181201
IS  - 1872-678X (Electronic)
IS  - 0165-0270 (Linking)
VI  - 204
IP  - 1
DP  - 2012 Feb 15
TI  - Can conditioned reinforcers and Variable-Ratio Schedules make food- and fluid
      control redundant? A comment on the NC3Rs Working Group's report.
PG  - 202-205
LID - S0165-0270(11)00169-5 [pii]
LID - 10.1016/j.jneumeth.2011.03.021 [doi]
AB  - This commentary challenges the conclusions of the NC3Rs Working Group's recent
      special report that food- or fluid control is sometimes necessary to conduct
      modern neuroscientific investigations in macaque monkeys (Prescott et al., 2010).
      Given the potential suffering of animals subjected to food- or fluid control, the
      decision to subject an animal to such practices should be taken hesitantly. That 
      decision hinges on to which extent the animal is willing to be involved in the
      task. The authors have done a scientific literature search and express expert
      opinion, but fail to mention two techniques that may greatly influence the
      animals' motivation to participate in the task and thus reduce the need for food-
      or fluid control, namely (1) the use of conditioned reinforcers in addition to
      primary reinforcers; and (2) the use of Variable-Ratio Schedules rather than
      continuous reinforcement. An ethical and humane approach to animal
      experimentation suggests that all options should be explored and thoroughly
      investigated before resorting to methods potentially challenging the animals'
      welfare.
CI  - Copyright (c) 2011. Published by Elsevier B.V.
FAU - Westlund, Karolina
AU  - Westlund K
AD  - The Swedish Institute for Infectious Disease Control, Nobels v 18, 171 82 Solna, 
      Sweden. Electronic address: karolina.westlund@smi.se.
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20110401
PL  - Netherlands
TA  - J Neurosci Methods
JT  - Journal of neuroscience methods
JID - 7905558
SB  - IM
CON - J Neurosci Methods. 2010 Nov 30;193(2):167-88. PMID: 20868708
MH  - Animals
MH  - Behavior, Animal/*physiology
MH  - *Behavioral Research
MH  - *Macaca
MH  - Motivation/*physiology
MH  - *Neurosciences
EDAT- 2011/04/05 06:00
MHDA- 2012/05/04 06:00
CRDT- 2011/04/05 06:00
PHST- 2010/11/25 00:00 [received]
PHST- 2011/03/15 00:00 [revised]
PHST- 2011/03/26 00:00 [accepted]
PHST- 2011/04/05 06:00 [entrez]
PHST- 2011/04/05 06:00 [pubmed]
PHST- 2012/05/04 06:00 [medline]
AID - S0165-0270(11)00169-5 [pii]
AID - 10.1016/j.jneumeth.2011.03.021 [doi]
PST - ppublish
SO  - J Neurosci Methods. 2012 Feb 15;204(1):202-205. doi:
      10.1016/j.jneumeth.2011.03.021. Epub 2011 Apr 1.


PMID- 21458349
OWN - NLM
STAT- MEDLINE
DCOM- 20110830
LR  - 20110418
IS  - 1953-8022 (Electronic)
IS  - 1246-7820 (Linking)
VI  - 18
IP  - 2
DP  - 2011 Apr
TI  - [European Blood Alliance (EBA) and EuroNet TMS: what challenges for the
      transfusion of tomorrow?].
PG  - 106-14
LID - 10.1016/j.tracli.2011.02.016 [doi]
AB  - The primary mission of the European Blood Alliance (EBA) is to contribute to the 
      safety and efficiency of the supply of blood products, cells and tissues, in
      developing an active network of blood establishments in Europe (25 countries).
      Its strategic objectives are to improve performance (through working groups and
      projects funded by the European Union), to engage in regulatory affairs
      (particularly at the European Commission level) to promote best practices and to 
      facilitate a network to collect and share knowledge and experiences. The main
      objective of EuroNet TMS, combining the blood scientific societies from more than
      30 countries in Europe, is to update and publish regularly, intended for
      policymakers, a White Book on the transfusion chain from donor to patient and
      probable or possible changes in the coming 5 years. Since 2008, EBA and EuroNet
      TMS actively collaborate on the drafting of the 2nd edition to be published in
      2011. The two presidents jointly drafted the final chapter outlining the major
      issues of transfusion for tomorrow, summarized thereafter. Transfusion will still
      be useful for a long time and for reasons of safety and ethics the voluntary and 
      unpaid donations, with non-profit blood establishments, will remain, the
      cornerstone of the supply of blood products. This renders crucial the continuous 
      improvement of donor management and optimal blood use. On the regulatory side,
      after 5 years of implementation, EU directives must be independently evaluated
      and the Blood Guide of the Council of Europe should gradually become a regulatory
      standard. Finally, if a competition should be introduced for the blood products, 
      it should be strictly regulated to prevent any threat to the security of their
      supply and quality for patients.
CI  - Copyright (c) 2011 Elsevier Masson SAS. All rights reserved.
FAU - Follea, G
AU  - Follea G
AD  - European Blood Alliance, 17, rue du Tabellion, 1050 Bruxelles, Belgique.
      g.follea@sanquin.nl
FAU - de Wit, J
AU  - de Wit J
FAU - Rouger, P
AU  - Rouger P
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - European Blood Alliance (EBA) et EuroNet TMS: quels enjeux pour la transfusion de
      demain?
DEP - 20110331
PL  - France
TA  - Transfus Clin Biol
JT  - Transfusion clinique et biologique : journal de la Societe francaise de
      transfusion sanguine
JID - 9423846
SB  - IM
MH  - Benchmarking/organization & administration
MH  - Blood Banks/legislation & jurisprudence/*organization & administration/standards
MH  - Blood Safety/standards
MH  - Blood Transfusion/legislation & jurisprudence/standards/*trends
MH  - Cooperative Behavior
MH  - Europe
MH  - European Union/organization & administration
MH  - Forecasting
MH  - Goals
MH  - Health Planning Organizations/*organization & administration
MH  - Humans
MH  - Interinstitutional Relations
MH  - International Agencies/organization & administration
MH  - Policy Making
MH  - Quality Improvement
EDAT- 2011/04/05 06:00
MHDA- 2011/08/31 06:00
CRDT- 2011/04/05 06:00
PHST- 2011/02/16 00:00 [received]
PHST- 2011/02/17 00:00 [accepted]
PHST- 2011/04/05 06:00 [entrez]
PHST- 2011/04/05 06:00 [pubmed]
PHST- 2011/08/31 06:00 [medline]
AID - S1246-7820(11)00042-5 [pii]
AID - 10.1016/j.tracli.2011.02.016 [doi]
PST - ppublish
SO  - Transfus Clin Biol. 2011 Apr;18(2):106-14. doi: 10.1016/j.tracli.2011.02.016.
      Epub 2011 Mar 31.


PMID- 21458188
OWN - NLM
STAT- MEDLINE
DCOM- 20120928
LR  - 20120511
IS  - 1872-7727 (Electronic)
IS  - 0720-048X (Linking)
VI  - 81
IP  - 6
DP  - 2012 Jun
TI  - The influence of body temperature on image contrast in post mortem MRI.
PG  - 1366-70
LID - 10.1016/j.ejrad.2011.02.062 [doi]
AB  - OBJECTIVE: To assess the temperature dependency of tissue contrast on post mortem
      magnetic resonance (PMMR) images both objectively and subjectively; and to
      visually demonstrate the changes of image contrast at various temperatures.
      MATERIALS AND METHODS: The study was approved by the responsible justice
      department and the ethics committee. The contrast of water, fat, and muscle was
      measured using regions of interest (ROI) in the orbit of 41 human corpses to
      assess how body temperature (range 2.1-39.8 degrees C) relates to image contrast 
      of T1-weighted (T1W) and T2-weighted (T2W) sequences on PMMR. Regressions were
      calculated using the method of least squares. Three readers judged visible
      changes of image contrast subjectively by consensus. RESULTS: There was a
      positive relationship between temperature and contrast on T1-weighted (T1W)
      images and between temperature and the contrast of fat/muscle on T2-weighted
      (T2W) images. There was a negative relationship between temperature and the
      contrast of water/fat and water/muscle on T2W images. Subjectively, the influence
      of temperature became visible below 20 degrees C on T2W images, and below 10
      degrees C on T1W images. CONCLUSION: Image contrast on PMMR depends on the
      temperature of a corpse. Radiologists involved in post mortem imaging must be
      aware of temperature-related changes in MR image contrast. To preserve technical 
      quality, scanning corpses below 10 degrees C should be avoided.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Ruder, Thomas D
AU  - Ruder TD
AD  - Center for Forensic Imaging and Virtopsy, Institute of Forensic Medicine,
      University of Bern, Buehlstrasse 20, CH-3012 Bern, Switzerland.
      thomas.ruder@irm.unibe.ch
FAU - Hatch, Gary M
AU  - Hatch GM
FAU - Siegenthaler, Lea
AU  - Siegenthaler L
FAU - Ampanozi, Garyfalia
AU  - Ampanozi G
FAU - Mathier, Sandra
AU  - Mathier S
FAU - Thali, Michael J
AU  - Thali MJ
FAU - Weber, Oliver M
AU  - Weber OM
LA  - eng
PT  - Journal Article
DEP - 20110331
PL  - Ireland
TA  - Eur J Radiol
JT  - European journal of radiology
JID - 8106411
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Body Temperature
MH  - Cadaver
MH  - Child
MH  - Female
MH  - Humans
MH  - Least-Squares Analysis
MH  - Linear Models
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - *Postmortem Changes
MH  - Whole Body Imaging
EDAT- 2011/04/05 06:00
MHDA- 2012/09/29 06:00
CRDT- 2011/04/05 06:00
PHST- 2011/01/07 00:00 [received]
PHST- 2011/02/28 00:00 [accepted]
PHST- 2011/04/05 06:00 [entrez]
PHST- 2011/04/05 06:00 [pubmed]
PHST- 2012/09/29 06:00 [medline]
AID - S0720-048X(11)00254-3 [pii]
AID - 10.1016/j.ejrad.2011.02.062 [doi]
PST - ppublish
SO  - Eur J Radiol. 2012 Jun;81(6):1366-70. doi: 10.1016/j.ejrad.2011.02.062. Epub 2011
      Mar 31.


PMID- 21458127
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20220409
IS  - 1531-5053 (Electronic)
IS  - 0278-2391 (Linking)
VI  - 69
IP  - 7
DP  - 2011 Jul
TI  - Maxillectomy through mandibulotomy--a retrospective clinical review.
PG  - 2040-7
LID - 10.1016/j.joms.2010.10.030 [doi]
AB  - PURPOSE: To review retrospectively the benefits of using mandibulotomy as an
      access for tumors involving the maxilla and infratemporal fossa. PATIENTS AND
      METHODS: Twenty-four consecutive patients with tumors involving the maxilla and
      infratemporal fossa underwent maxillectomy through mandibular access osteotomy.
      Patient details and postoperative follow-up were reviewed and recorded.
      Postoperative complications such as neural morbidity and problems relevant to the
      procedure were evaluated. Ethical clearance from the medical practices board of
      the hospital was not required for this study. RESULTS: All but 1 patient
      underwent en bloc resection of the maxillary tumor with a histologically negative
      margin. One patient with adenoid cystic carcinoma had a positive orbital margin. 
      Residual mouth opening smaller than 2.5 cm was observed in 4 patients. Healing of
      the osteotomy site was satisfactory in 21 patients. Three patients had
      osteotomy-related complications that required secondary intervention. Neural
      morbidity was temporary and cosmetic outcome of the procedure was excellent.
      CONCLUSION: Mandibular access osteotomy is an acceptable approach to tumors
      involving the maxilla and infratemporal fossa. The advantages of wide exposure,
      minimal morbidity, and good cosmesis make it superior to the conventional
      panfacial approach. This article highlights the advantages of this procedure and 
      discusses conventional approaches with review of the literature.
CI  - Copyright (c) 2011 American Association of Oral and Maxillofacial Surgeons.
      Published by Elsevier Inc. All rights reserved.
FAU - Nair, Sanjiv
AU  - Nair S
AD  - Department of Maxillofacial Surgery, Bangalore Institute of Dental Sciences,
      Bangalore, India. snmaxfax@gmail.com
FAU - Sridhar, K R
AU  - Sridhar KR
FAU - Shah, Anjan
AU  - Shah A
FAU - Kumar, Balasubramaniam
AU  - Kumar B
FAU - Nayak, Kishore
AU  - Nayak K
FAU - Shetty, Pritam
AU  - Shetty P
LA  - eng
PT  - Journal Article
DEP - 20110331
PL  - United States
TA  - J Oral Maxillofac Surg
JT  - Journal of oral and maxillofacial surgery : official journal of the American
      Association of Oral and Maxillofacial Surgeons
JID - 8206428
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Adenoid Cystic/surgery
MH  - Carcinoma, Squamous Cell/surgery
MH  - Esthetics
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Lingual Nerve Injuries
MH  - Male
MH  - Mandible/*surgery
MH  - Maxilla/*surgery
MH  - Maxillary Neoplasms/*surgery
MH  - Middle Aged
MH  - Neck Dissection
MH  - Orbit/surgery
MH  - Osteotomy/*methods
MH  - Postoperative Complications
MH  - Reconstructive Surgical Procedures
MH  - Reoperation
MH  - Retrospective Studies
MH  - Skull Neoplasms/surgery
MH  - Temporal Bone/surgery
MH  - Treatment Outcome
MH  - Trigeminal Nerve Injuries
MH  - Trismus/etiology
MH  - Wound Healing/physiology
MH  - Young Adult
EDAT- 2011/04/05 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/04/05 06:00
PHST- 2010/05/25 00:00 [received]
PHST- 2010/08/01 00:00 [revised]
PHST- 2010/10/07 00:00 [accepted]
PHST- 2011/04/05 06:00 [entrez]
PHST- 2011/04/05 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - S0278-2391(10)01473-4 [pii]
AID - 10.1016/j.joms.2010.10.030 [doi]
PST - ppublish
SO  - J Oral Maxillofac Surg. 2011 Jul;69(7):2040-7. doi: 10.1016/j.joms.2010.10.030.
      Epub 2011 Mar 31.


PMID- 21457851
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20191210
IS  - 1097-6752 (Electronic)
IS  - 0889-5406 (Linking)
VI  - 139
IP  - 4
DP  - 2011 Apr
TI  - Ethics in orthodontics. Truth in advertising.
PG  - 429-30
LID - 10.1016/j.ajodo.2011.01.004 [doi]
FAU - Greco, Peter M
AU  - Greco PM
AD  - Philadelphia, PA, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Orthod Dentofacial Orthop
JT  - American journal of orthodontics and dentofacial orthopedics : official
      publication of the American Association of Orthodontists, its constituent
      societies, and the American Board of Orthodontics
JID - 8610224
SB  - IM
MH  - Advertising/*ethics
MH  - *Ethics, Dental
MH  - Humans
MH  - Orthodontics/*ethics
MH  - Professional Competence
MH  - Truth Disclosure/*ethics
MH  - United States
MH  - United States Federal Trade Commission
EDAT- 2011/04/05 06:00
MHDA- 2011/06/03 06:00
CRDT- 2011/04/05 06:00
PHST- 2011/01/01 00:00 [received]
PHST- 2011/01/01 00:00 [revised]
PHST- 2011/01/01 00:00 [accepted]
PHST- 2011/04/05 06:00 [entrez]
PHST- 2011/04/05 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
AID - S0889-5406(11)00049-7 [pii]
AID - 10.1016/j.ajodo.2011.01.004 [doi]
PST - ppublish
SO  - Am J Orthod Dentofacial Orthop. 2011 Apr;139(4):429-30. doi:
      10.1016/j.ajodo.2011.01.004.


PMID- 21457676
OWN - NLM
STAT- MEDLINE
DCOM- 20120118
LR  - 20220311
IS  - 1555-2101 (Electronic)
IS  - 0160-6689 (Linking)
VI  - 72
IP  - 11
DP  - 2011 Nov
TI  - An algorithm-based approach to first-episode schizophrenia: response rates over 3
      prospective antipsychotic trials with a retrospective data analysis.
PG  - 1439-44
LID - 10.4088/JCP.09m05785yel [doi]
AB  - OBJECTIVE: Early, effective treatment in first-episode schizophrenia is
      advocated, although evidence based on a systematic approach over multiple
      antipsychotic trials is lacking. Employing a naturalistic design, we examined
      response rates over 3 circumscribed antipsychotic trials. METHOD: Between June
      2003 and December 2008, 244 individuals with first-episode schizophrenia or
      schizoaffective disorder according to DSM-IV criteria were treated at the Centre 
      for Addiction and Mental Health, Toronto, Ontario, Canada, following an algorithm
      that moved them through 2 antipsychotic trials, followed by a trial with
      clozapine. For the first 2 trials, treatment consisted of risperidone followed by
      olanzapine, or vice versa; each trial consisted of 3 stages (low-, full-, or
      high-dose) lasting up to 4 weeks at each level and adjusted according to
      response/tolerability. Clinical response was defined as a Clinical Global
      Impressions-Improvement score of 2 (much improved) or 1 (very much improved)
      and/or a Brief Psychiatric Rating Scale Thought Disorder subscale score </= 6.
      Data were analyzed retrospectively, and publication of anonymized clinical data
      was approved by the Research Ethics Board of the Centre for Addiction and Mental 
      Health in May 2003. RESULTS: In trial 1, 74.5% of individuals responded, with
      rates significantly higher for olanzapine (82.1%, 115/140) versus risperidone
      (66.3%, 69/104; P = .005). With trial 2, response rate dropped dramatically to
      16.6% but again was significantly higher for olanzapine (25.7%, 9/35) compared to
      risperidone (4.0%, 1/25; P = .04). Response rate climbed above 70% once more,
      specifically 75.0% (21/28), in those individuals who agreed to a third trial with
      clozapine. CONCLUSIONS: Results confirm a high response rate (75%) to initial
      antipsychotic treatment in first-episode schizophrenia. A considerably lower
      response rate (< 20%) occurs with a second antipsychotic trial. Results here were
      specific to olanzapine and risperidone, suggesting clinical differences (ie,
      olanzapine more effective than risperidone). A subsequent trial with clozapine is
      clearly warranted, although it remains unclear whether outcome would be further
      enhanced if it were used earlier in the treatment algorithm.
CI  - (c) Copyright 2011 Physicians Postgraduate Press, Inc.
FAU - Agid, Ofer
AU  - Agid O
AD  - Schizophrenia Program, Centre for Addiction and Mental Health, 250 College St,
      Toronto, Ontario, M5T 1R8, Canada. Ofer_agid@camh.net
FAU - Arenovich, Tamara
AU  - Arenovich T
FAU - Sajeev, Gautam
AU  - Sajeev G
FAU - Zipursky, Robert B
AU  - Zipursky RB
FAU - Kapur, Shitij
AU  - Kapur S
FAU - Foussias, George
AU  - Foussias G
FAU - Remington, Gary
AU  - Remington G
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110308
PL  - United States
TA  - J Clin Psychiatry
JT  - The Journal of clinical psychiatry
JID - 7801243
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Dibenzothiazepines)
RN  - 12794-10-4 (Benzodiazepines)
RN  - 2S3PL1B6UJ (Quetiapine Fumarate)
RN  - J60AR2IKIC (Clozapine)
RN  - L6UH7ZF8HC (Risperidone)
RN  - N7U69T4SZR (Olanzapine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Algorithms
MH  - Antipsychotic Agents/administration & dosage/*therapeutic use
MH  - Benzodiazepines/therapeutic use
MH  - Clozapine/therapeutic use
MH  - Dibenzothiazepines/therapeutic use
MH  - Female
MH  - Humans
MH  - Male
MH  - Olanzapine
MH  - Prospective Studies
MH  - Quetiapine Fumarate
MH  - Retrospective Studies
MH  - Risperidone/therapeutic use
MH  - Schizophrenia/*drug therapy
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2011/04/05 06:00
MHDA- 2012/01/19 06:00
CRDT- 2011/04/05 06:00
PHST- 2009/10/21 00:00 [received]
PHST- 2010/04/26 00:00 [accepted]
PHST- 2011/04/05 06:00 [entrez]
PHST- 2011/04/05 06:00 [pubmed]
PHST- 2012/01/19 06:00 [medline]
AID - 10.4088/JCP.09m05785yel [doi]
PST - ppublish
SO  - J Clin Psychiatry. 2011 Nov;72(11):1439-44. doi: 10.4088/JCP.09m05785yel. Epub
      2011 Mar 8.


PMID- 21457377
OWN - NLM
STAT- MEDLINE
DCOM- 20111013
LR  - 20110614
IS  - 1365-2702 (Electronic)
IS  - 0962-1067 (Linking)
VI  - 20
IP  - 13-14
DP  - 2011 Jul
TI  - Ethical challenges in nursing emergency practice.
PG  - 2064-70
LID - 10.1111/j.1365-2702.2010.03606.x [doi]
AB  - AIM: The aim of this study is to illuminate nurses' experiences of being in
      ethically difficult situations in an emergency ward. BACKGROUND: Nurses working
      in emergency practice are frequently faced with ethical issues and challenges in 
      their work. Many studies have been conducted concerning ethical challenges, but
      no empirical studies related to ethics in emergency wards in Norway have been
      carried out. DESIGN: A qualitative interview study was conducted. METHOD: Five
      registered nurses were interviewed about their experiences in an emergency ward
      in a hospital in Norway. The concept of ethically difficult situations was not
      defined that the question was left open for the respondents themselves to define 
      what they experienced as ethically difficult. A phenomenological hermeneutical
      method was used. RESULTS: The most salient point revealed by the study is the
      enormous difficulty associated with the prioritisation of tasks and the attendant
      sense of responsibility which this entailed, particularly in the case of nurses
      in charge. The narratives reveal the vulnerability of the nurses in ethically
      challenging situations. CONCLUSIONS: Despite the pressure of responsibility for
      their patients, the nurses enjoy a sense of satisfaction in their work. Those
      recognising the ethical dimension in their own professional practice are unable
      to hide behind others and thus evade their share of the responsibility. RELEVANCE
      TO CLINICAL PRACTICE: Nurses with similar experiences may find the results
      credible recognising the descriptions or interpretations and seeing them in
      relation to similar situations. Nurses working on medical and surgical wards, in 
      nursing homes and community care may also feel a great responsibility,
      difficulties in prioritising and a lack of time for the patients.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Langeland, Kari
AU  - Langeland K
AD  - Faculty of Health Science, Vestfold University College, Vestfold, Norway.
      kari.langeland@hive.no
FAU - Sorlie, Venke
AU  - Sorlie V
LA  - eng
PT  - Journal Article
DEP - 20110404
PL  - England
TA  - J Clin Nurs
JT  - Journal of clinical nursing
JID - 9207302
MH  - *Emergency Nursing
MH  - *Ethics, Nursing
MH  - Norway
EDAT- 2011/04/05 06:00
MHDA- 2011/10/14 06:00
CRDT- 2011/04/05 06:00
PHST- 2011/04/05 06:00 [entrez]
PHST- 2011/04/05 06:00 [pubmed]
PHST- 2011/10/14 06:00 [medline]
AID - 10.1111/j.1365-2702.2010.03606.x [doi]
PST - ppublish
SO  - J Clin Nurs. 2011 Jul;20(13-14):2064-70. doi: 10.1111/j.1365-2702.2010.03606.x.
      Epub 2011 Apr 4.


PMID- 21457094
OWN - NLM
STAT- MEDLINE
DCOM- 20111121
LR  - 20110726
IS  - 1937-335X (Electronic)
IS  - 1937-3341 (Linking)
VI  - 17
IP  - 15-16
DP  - 2011 Aug
TI  - Combined transplantation of bone marrow stromal cell-derived neural progenitor
      cells with a collagen sponge and basic fibroblast growth factor releasing
      microspheres enhances recovery after cerebral ischemia in rats.
PG  - 1993-2004
LID - 10.1089/ten.TEA.2010.0585 [doi]
AB  - Bone marrow stromal cells (MSCs) are a useful source of cells because of their
      abundant supply and few associated ethical problems. We have previously reported 
      that neural progenitor cells (NS-MSCs) can be effectively induced from MSCs and
      differentiate into neurons to contribute to functional recovery when transplanted
      into the rat stroke model. In this study, we attempted to enhance the therapeutic
      effects of NS-MSCs with a collagen sponge and basic fibroblast growth factor
      (bFGF) releasing microspheres. NS-MSCs were generated from MSCs by transfection
      of Notch-1 intracellular domain followed by culturing the cells in a
      free-floating culture system. The resulting NS-MSCs were transplanted into the
      rats with induced brain ischemia by using collagen sponges as scaffolds for
      transplanted cells, and with bFGF incorporated into gelatin microspheres to aid
      neovascularization around the transplanted region and proliferation of neural
      stem cells/neural progenitor cells. In culture, NS-MSCs successfully formed
      spheres containing cells highly expressing neural progenitor markers. Cell
      survival, neovascularization, and proliferation of host neural stem cells/neural 
      progenitor cells were improved in animals that received NS-MSCs together with
      these biomaterials. Behavioral analysis also revealed significant functional
      recovery. These observations demonstrate that transplantation of NS-MSCs in
      combination with a collagen sponge and bFGF releasing microspheres significantly 
      improves histological and functional recovery in the rat stroke model. When used 
      with these biomaterials, NS-MSCs would be a promising cell source for treating
      stroke and neurodegenerative diseases.
FAU - Matsuse, Dai
AU  - Matsuse D
AD  - Department of Stem Cell Biology and Histology, Tohoku University Graduate School 
      of Medicine, Sendai, Japan.
FAU - Kitada, Masaaki
AU  - Kitada M
FAU - Ogura, Fumitaka
AU  - Ogura F
FAU - Wakao, Shohei
AU  - Wakao S
FAU - Kohama, Misaki
AU  - Kohama M
FAU - Kira, Jun-ichi
AU  - Kira J
FAU - Tabata, Yasuhiko
AU  - Tabata Y
FAU - Dezawa, Mari
AU  - Dezawa M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110512
PL  - United States
TA  - Tissue Eng Part A
JT  - Tissue engineering. Part A
JID - 101466659
RN  - 103107-01-3 (Fibroblast Growth Factor 2)
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Bone Marrow Cells/*cytology/drug effects/metabolism
MH  - Brain Ischemia/pathology/*physiopathology/*therapy
MH  - Cell Proliferation/drug effects
MH  - Collagen/*pharmacology
MH  - Fibroblast Growth Factor 2/*pharmacology
MH  - Immunohistochemistry
MH  - Microspheres
MH  - Neural Stem Cells/cytology/drug effects/*transplantation
MH  - Rats
MH  - Rats, Wistar
MH  - Recovery of Function/*drug effects
MH  - Spheroids, Cellular/cytology/drug effects
MH  - Stromal Cells/cytology/drug effects/metabolism
MH  - Tissue Scaffolds/chemistry
EDAT- 2011/04/05 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/04/05 06:00
PHST- 2011/04/05 06:00 [entrez]
PHST- 2011/04/05 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1089/ten.TEA.2010.0585 [doi]
PST - ppublish
SO  - Tissue Eng Part A. 2011 Aug;17(15-16):1993-2004. doi: 10.1089/ten.TEA.2010.0585. 
      Epub 2011 May 12.


PMID- 21456499
OWN - NLM
STAT- MEDLINE
DCOM- 20110414
LR  - 20110825
IS  - 0952-6862 (Print)
IS  - 0952-6862 (Linking)
VI  - 24
IP  - 1
DP  - 2011
TI  - Sustainable leadership in a Thai healthcare services provider.
PG  - 67-80
AB  - PURPOSE: Rhineland leadership practices contrast sharply with the prevailing
      Anglo/US business model of short-term maximization of profitability, and are said
      to lead to greater corporate sustainability, at least in highly developed
      economies. However, the applicability of Rhineland leadership to less developed
      economies has not yet been demonstrated. This paper sets out to compare the
      business practices of a social enterprise that delivers healthcare services in
      Thailand and Avery's 19 sustainable leadership practices derived from Rhineland
      enterprises. DESIGN/METHODOLOGY/APPROACH: Adopting a case study approach,
      multi-data collection methods included non-participant observations made during
      visits to the enterprise, and reference to internal and published documentation
      and information. Semi-structured interview sessions were held with many
      stakeholders, including top management, staff, patients and a former consultant. 
      FINDINGS: In the Thai healthcare organization studied, evidence was found for
      compliance with 15 of Avery's 19 sustainable leadership elements, but to varying 
      degrees. The elements were grouped into six core sets of practices: adopting a
      long-term perspective, staff development, organizational culture, innovation,
      social responsibility, and ethical behavior. One element was found to be not
      applicable, and no evidence was found for conformity with Rhineland principles on
      the remaining three sustainable practices. The paper concludes that Avery's 19
      Rhineland practices provide a useful framework for evaluating the corporate
      sustainability of this Thai enterprise. PRACTICAL IMPLICATIONS: Healthcare
      enterprises in Thailand and possibly in other Asian countries that wish to
      sustain their organizational success could adopt Avery's 19 Sustainable
      Leadership Grid elements to examine their leadership practices, and adjust them
      to become more sustainable. ORIGINALITY/VALUE: The relevance of Rhineland
      sustainable leadership principles to enterprises in less developed economies
      remains to be investigated. This study attempts to uncover this unknown.
FAU - Kantabutra, Sooksan
AU  - Kantabutra S
AD  - College of Management, Mahidol University, Bangkok, Thailand.
      cmsooksan@mahidol.ac.th
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Health Care Qual Assur
JT  - International journal of health care quality assurance
JID - 8916799
MH  - Ethics, Institutional
MH  - *Hospital Administration
MH  - Humans
MH  - *Leadership
MH  - Organizational Case Studies
MH  - Organizational Culture
MH  - Organizational Innovation
MH  - Staff Development
MH  - Thailand
EDAT- 2011/04/05 06:00
MHDA- 2011/04/16 06:00
CRDT- 2011/04/05 06:00
PHST- 2011/04/05 06:00 [entrez]
PHST- 2011/04/05 06:00 [pubmed]
PHST- 2011/04/16 06:00 [medline]
AID - 10.1108/09526861111098256 [doi]
PST - ppublish
SO  - Int J Health Care Qual Assur. 2011;24(1):67-80. doi: 10.1108/09526861111098256.


PMID- 21455899
OWN - NLM
STAT- MEDLINE
DCOM- 20110614
LR  - 20110401
IS  - 0047-262X (Print)
VI  - 58
IP  - 2
DP  - 2011 Apr
TI  - [Introduction to nursing aesthetics].
PG  - 93-7
AB  - Empirical, aesthetic, ethical, and personal knowing are the four fundamental
      patterns of knowledge inquiry. Of these, the aesthetic knowing pattern is least
      discussed in nursing literature. This article discusses the definition of nursing
      aesthetics; its utilization in practice; and correlations between aesthetics and 
      clinical practice. One of the advantages inherent to nursing is its ability to
      deliver skillful care directly to patients. Skillful performance is essential to 
      reduce discrepancies between goals and patterns. Aesthetic nursing addresses more
      than the form of nursing. It further addresses the crucial elements of nursing
      knowledge. The science of nursing is influential in its ability to attain harmony
      among abundant empiric content, power of beneficence, and pleasure of aesthetic
      experience. In clinical practice, nurses can employ aesthetic nursing through
      various channels to create meaning and promote the professional image of nurses. 
      Concepts listed in this article may be utilized in clinical supervision, practice
      and education.
FAU - Chen, Chen-Jung
AU  - Chen CJ
AD  - School of Nursing, Jen-Teh Junior of Medicine Nursing and Management, & Doctoral 
      Student, Institute of Medical Science, Tzu Chi University, ROC.
FAU - Tsai, Chuan-Hsiu
AU  - Tsai CH
FAU - Chen, Yi-Chang
AU  - Chen YC
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China (Republic : 1949- )
TA  - Hu Li Za Zhi
JT  - Hu li za zhi The journal of nursing
JID - 0073267
SB  - IM
MH  - *Esthetics/classification
MH  - Humans
MH  - *Nursing
EDAT- 2011/04/02 06:00
MHDA- 2011/06/15 06:00
CRDT- 2011/04/02 06:00
PHST- 2011/04/02 06:00 [entrez]
PHST- 2011/04/02 06:00 [pubmed]
PHST- 2011/06/15 06:00 [medline]
PST - ppublish
SO  - Hu Li Za Zhi. 2011 Apr;58(2):93-7.


PMID- 21455550
OWN - NLM
STAT- MEDLINE
DCOM- 20110919
LR  - 20151119
IS  - 1545-9616 (Print)
IS  - 1545-9616 (Linking)
VI  - 10
IP  - 4
DP  - 2011 Apr
TI  - An open-label, prospective cohort pilot study to evaluate the efficacy and safety
      of etanercept in the treatment of moderate to severe plaque psoriasis in patients
      who have not had an adequate response to adalimumab.
PG  - 396-402
AB  - BACKGROUND: The past several years have seen the approval of five different
      biologic agents for the treatment of moderate to severe plaque psoriasis in the
      United States and Canada. Psoriasis has proven to be a difficult disease to treat
      and treatment failures, even with newer biologic therapies, are not uncommon. The
      vast majority of clinical data for these medications is derived from treatment of
      biologic-naive patients, or patients who have not responded to, or lost response 
      to, or not tolerated systemic therapy for psoriasis. There is currently little
      data available on therapeutic response of a second biologic therapy after loss of
      response, or no response, to the first biologic therapy initiated. It has become 
      common clinical practice to switch medications that are structurally distinct but
      therapeutically similar in order to achieve an improved clinical outcome.
      Therapeutic interchange now is being applied to the biologic agents used to treat
      psoriasis. OBJECTIVES: Using a proof of concept study, describe the response of
      etanercept after adalimumab has failed to produce a satisfactory response in
      moderate to severe plaque psoriasis. METHODS: A total of 10 biologically naive
      patients with moderate to severe psoriasis who were initiated on adalimumab for
      at least 12 weeks but had a Physician's Global Assessment (PGA) of mild or worse 
      were transitioned to commercial etanercept 50 mg twice weekly (BIW) for 12 weeks 
      followed by a dose reduction to 50 mg once weekly (OW) for an additional 12
      weeks. Ethics approval was obtained and the study registered with
      ClinicalTrials.gov (NCT00833729). The primary outcome measured was the mean
      change in Physician?s Global Assessment (PGA) score (range 0-5) from baseline
      (when the first etanercept injection is given) to 12 weeks of etanercept therapy.
      The secondary outcomes measures included the mean change in Dermatology Quality
      of Life Index (DLQI), mean change in body surface area (BSA) covered in
      psoriasis, Subject's Global Assessment of disease (SGA), proportion of patients
      achieving an improvement in PGA score from baseline to 12 weeks and again at 24
      weeks and safety. RESULTS: Overall, there were significant favorable changes in
      all outcomes measured (PGA, SGA, BSA and DLQI) with respect to etanercept's
      efficacy after an inadequate response to at least 12 weeks of adalimumab therapy.
      There were no significant safety issues noted especially during the transition
      period from adalimumab to etanercept. ClinicalTrials.gov identifier: NCT00833729.
FAU - Vender, Ronald
AU  - Vender R
AD  - Dermatrials Research; McMaster University, Hamilton, ON, Canada.
LA  - eng
SI  - ClinicalTrials.gov/NCT00833729
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - J Drugs Dermatol
JT  - Journal of drugs in dermatology : JDD
JID - 101160020
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antibodies, Monoclonal, Humanized)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - FYS6T7F842 (Adalimumab)
RN  - OP401G7OJC (Etanercept)
SB  - IM
MH  - Adalimumab
MH  - Adult
MH  - Aged
MH  - Antibodies, Monoclonal/adverse effects/*therapeutic use
MH  - Antibodies, Monoclonal, Humanized
MH  - Cohort Studies
MH  - Etanercept
MH  - Female
MH  - Humans
MH  - Immunoglobulin G/adverse effects/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - Prospective Studies
MH  - Psoriasis/*therapy
MH  - Receptors, Tumor Necrosis Factor/*therapeutic use
MH  - Severity of Illness Index
MH  - Treatment Outcome
MH  - Tumor Necrosis Factor-alpha/antagonists & inhibitors
EDAT- 2011/04/02 06:00
MHDA- 2011/09/20 06:00
CRDT- 2011/04/02 06:00
PHST- 2011/04/02 06:00 [entrez]
PHST- 2011/04/02 06:00 [pubmed]
PHST- 2011/09/20 06:00 [medline]
PST - ppublish
SO  - J Drugs Dermatol. 2011 Apr;10(4):396-402.


PMID- 21455414
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1998-3751 (Electronic)
IS  - 0253-7613 (Linking)
VI  - 43
IP  - 1
DP  - 2011 Feb
TI  - Clinical trials of antihypertensives: Nature of control and design.
PG  - 13-7
LID - 10.4103/0253-7613.75659 [doi]
AB  - This paper reviews the critical issues in the control and design of
      antihypertension (anti-HT) clinical trials. The international guidelines and
      current clinical and biostatistical practices were reviewed for relevant
      clinical, design, end-point assessments and regulatory issues. The results are
      grouped mainly into ethical, protocol and assessment issues. Ethical issues arise
      as placebo-controlled trials (PCTs) for HT-lowering agents in patients with
      moderate to severe HT are undertaken. Patients with organ damage due to HT should
      not be included in long-term PCT. Active-control trials, however, are suitable
      for all randomized subsets of patients, including men and women, and different
      ethnic and age groups. Severity subgroups must be studied separately with
      consideration to specific study design. Mortality and morbidity outcome studies
      are not required in anti-HT trials except when significant mortality and
      cardiovascular morbidity are suspected. Generally, changes in both systolic and
      diastolic blood pressures (BP) at the end of the dosing interval from the
      baseline are compared between the active and the control arms as the primary
      endpoint of anti-HT effect. Onset of the anti-HT effect can be studied as the
      secondary endpoint. For maintenance of efficacy, long-term studies of >/=6 months
      need to be undertaken. Error-free measurement of BP is a serious issue as
      spontaneous changes in BP are large and active drug effect on diastolic BP is
      often small. Placebo-controlled short-term studies (of ~12 weeks) for
      dose-response and titration are very useful. Safety studies must be very vigilant
      on hypotension, orthostatic hypotension and effects on heart. In dose-response
      studies, at least three doses in addition to placebo should be used to well
      characterize the benefits and side-effects.
FAU - Chakraborty, Bhaswat S
AU  - Chakraborty BS
AD  - Cadila Pharmaceuticals, Ahmedabad, Gujarat - 387 810, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Pharmacol
JT  - Indian journal of pharmacology
JID - 7902477
PMC - PMC3062112
OTO - NOTNLM
OT  - Blood pressure
OT  - endpoints
OT  - good clinical practices
OT  - hypertension
OT  - randomized clinical trials
EDAT- 2011/04/02 06:00
MHDA- 2011/04/02 06:01
CRDT- 2011/04/02 06:00
PHST- 2010/05/19 00:00 [received]
PHST- 2010/08/21 00:00 [revised]
PHST- 2010/10/21 00:00 [accepted]
PHST- 2011/04/02 06:00 [entrez]
PHST- 2011/04/02 06:00 [pubmed]
PHST- 2011/04/02 06:01 [medline]
AID - 10.4103/0253-7613.75659 [doi]
PST - ppublish
SO  - Indian J Pharmacol. 2011 Feb;43(1):13-7. doi: 10.4103/0253-7613.75659.


PMID- 21455191
OWN - NLM
STAT- MEDLINE
DCOM- 20120312
LR  - 20191210
IS  - 1476-5624 (Electronic)
IS  - 1362-4393 (Linking)
VI  - 49
IP  - 4
DP  - 2011 Apr
TI  - New techniques? Yes, but let it be ethical. A warning from ISCoS.
PG  - 485
LID - 10.1038/sc.2011.25 [doi]
FAU - Wyndaele, J J
AU  - Wyndaele JJ
LA  - eng
PT  - Editorial
PT  - Introductory Journal Article
PL  - England
TA  - Spinal Cord
JT  - Spinal cord
JID - 9609749
SB  - IM
MH  - Humans
MH  - Outcome Assessment, Health Care/ethics/methods/*standards
MH  - Quackery/*ethics/*prevention & control
MH  - Spinal Cord Injuries/physiopathology/*surgery
MH  - Stem Cell Transplantation/adverse effects/economics/*ethics
EDAT- 2011/04/02 06:00
MHDA- 2012/03/13 06:00
CRDT- 2011/04/02 06:00
PHST- 2011/04/02 06:00 [entrez]
PHST- 2011/04/02 06:00 [pubmed]
PHST- 2012/03/13 06:00 [medline]
AID - sc201125 [pii]
AID - 10.1038/sc.2011.25 [doi]
PST - ppublish
SO  - Spinal Cord. 2011 Apr;49(4):485. doi: 10.1038/sc.2011.25.


PMID- 21454886
OWN - NLM
STAT- MEDLINE
DCOM- 20120313
LR  - 20191210
IS  - 1552-8456 (Electronic)
IS  - 0193-9459 (Linking)
VI  - 33
IP  - 8
DP  - 2011 Dec
TI  - Putting the bio in biobehavioral: animal models.
PG  - 1017-29
LID - 10.1177/0193945911403776 [doi]
AB  - Animal models are useful in research that examines physiological mechanisms and, 
      as such, are invaluable in developing therapies to alleviate illness and promote 
      health. Ethical considerations are essential for proper animal use and include
      replacement by nonanimal models where possible, reduction in the numbers of
      animals used, and refinement of experimental protocols to reduce animal
      suffering. Choosing the optimum model depends on the long- and short-term goals
      of the project, and the choice of a model goes hand in hand with appropriate
      study design. Five key features to think about when choosing a model are as
      follows: model asymmetry, necessary differences, specificity to the study, model 
      validity, and model improvement. Appropriate use of both male and female animals 
      has also become an important issue in recent times. These considerations will
      assist in understanding animal model use.
FAU - Holden, Janean E
AU  - Holden JE
AD  - The University of Michigan, Ann Arbor, MI 48109-5482, USA. holdenje@umich.edu
LA  - eng
PT  - Journal Article
PT  - Validation Study
DEP - 20110331
PL  - United States
TA  - West J Nurs Res
JT  - Western journal of nursing research
JID - 7905435
SB  - IM
MH  - Animals
MH  - Female
MH  - *Health Behavior
MH  - Male
MH  - Mice
MH  - *Models, Animal
MH  - Rats
EDAT- 2011/04/02 06:00
MHDA- 2012/03/14 06:00
CRDT- 2011/04/02 06:00
PHST- 2011/04/02 06:00 [entrez]
PHST- 2011/04/02 06:00 [pubmed]
PHST- 2012/03/14 06:00 [medline]
AID - 0193945911403776 [pii]
AID - 10.1177/0193945911403776 [doi]
PST - ppublish
SO  - West J Nurs Res. 2011 Dec;33(8):1017-29. doi: 10.1177/0193945911403776. Epub 2011
      Mar 31.


PMID- 21454361
OWN - NLM
STAT- MEDLINE
DCOM- 20120131
LR  - 20111114
IS  - 1468-2044 (Electronic)
IS  - 0003-9888 (Linking)
VI  - 96
IP  - 12
DP  - 2011 Dec
TI  - The challenge of the information culture for the paediatrician.
PG  - 1167-72
LID - 10.1136/adc.2009.178129 [doi]
AB  - 'Liberating the NHS' and the new outcomes framework place information at the
      heart of the management of the National Health Service (NHS) and develop further 
      the quality framework defined by Lord Darzi. In support of children,
      paediatricians have a responsibility to understand the informatics agenda and to 
      ensure that data collection is as accurate as possible. There are particular
      difficulties in supplying a comprehensive health record for children and
      providing them with the benefits of access to their health records. It is
      essential that paediatricians work to ensure that these problems are overcome and
      that children do not miss out because of legal, practical and ethical issues
      which can be overcome, but often are permitted to stand in the way of real
      improvements.
FAU - Spencer, Andy
AU  - Spencer A
AD  - The NHS Information Centre, 1 Trevelyan Square, Boar Lane, Leeds LS1 6AE, UK.
      andy.spencer@ic.nhs.uk
FAU - Low, David
AU  - Low D
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110331
PL  - England
TA  - Arch Dis Child
JT  - Archives of disease in childhood
JID - 0372434
SB  - IM
MH  - Child
MH  - Child Health Services/*organization & administration
MH  - Forms and Records Control/organization & administration
MH  - Humans
MH  - Medical Informatics/*organization & administration
MH  - Medical Records/standards
MH  - Pediatrics/*trends
MH  - Physician's Role
MH  - Quality Assurance, Health Care/methods
MH  - State Medicine/*organization & administration
EDAT- 2011/04/02 06:00
MHDA- 2012/02/01 06:00
CRDT- 2011/04/02 06:00
PHST- 2011/04/02 06:00 [entrez]
PHST- 2011/04/02 06:00 [pubmed]
PHST- 2012/02/01 06:00 [medline]
AID - adc.2009.178129 [pii]
AID - 10.1136/adc.2009.178129 [doi]
PST - ppublish
SO  - Arch Dis Child. 2011 Dec;96(12):1167-72. doi: 10.1136/adc.2009.178129. Epub 2011 
      Mar 31.


PMID- 21454029
OWN - NLM
STAT- MEDLINE
DCOM- 20120619
LR  - 20121115
IS  - 1872-7727 (Electronic)
IS  - 0720-048X (Linking)
VI  - 81
IP  - 3
DP  - 2012 Mar
TI  - Diffusion-weighted MR imaging allows monitoring the effect of combretastatin A4
      phosphate on rabbit implanted VX2 tumor model: 12-day dynamic results.
PG  - 578-83
LID - 10.1016/j.ejrad.2011.03.009 [doi]
AB  - OBJECTIVES: To investigate the 12-day dynamic characteristics of tumor response
      to intravenous administration of CA4P in rabbit VX2 tumor models. METHODS: Study 
      protocol was approved by local ethical committee for animal care and use. Sixteen
      rabbits with 32 tumors on bilateral legs were randomly divided into treated and
      control groups. Conventional and DWI images were acquired before and 24 h, 4
      days, 8 days and 12 days after treatment. The dynamic changes of tumor on images 
      were correlated with histological results. ADCs were compared among and between
      groups at different time points. RESULTS: The tumors in treated group grew slower
      than those in control group. In treaded group, the mean ADC decreased slightly at
      24 h point due to cell edema caused by ischemia. Then, it increased significantly
      at 4 days and 8 days because of progressive central necrosis. Finally, peripheral
      tumor proliferation caused a second decrease of ADC at 12 days. The significant
      difference of DeltaADC% between the two groups at 24 h, 4 days and 8 days
      indicated that the change of ADC in treated group was really caused by CA4P.
      CONCLUSION: The dynamic histological changes of tumor caused by CA4P as reflected
      exactly by diffusion-weighted MR imaging indicate a noninvasive measure for
      monitoring tumor vascular targeting treatment.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Shao, Haibo
AU  - Shao H
AD  - Department of Radiology, The First Hospital of China Medical University,
      Shenyang, China. haiboshao@yahoo.com.cn
FAU - Ni, Yicheng
AU  - Ni Y
FAU - Dai, Xu
AU  - Dai X
FAU - Zhang, Jian
AU  - Zhang J
FAU - Chen, Feng
AU  - Chen F
FAU - Fan, Guoguang
AU  - Fan G
FAU - Sun, Ziping
AU  - Sun Z
FAU - Li, Yaming
AU  - Li Y
FAU - Zhou, Hongxu
AU  - Zhou H
FAU - Xu, Ke
AU  - Xu K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110330
PL  - Ireland
TA  - Eur J Radiol
JT  - European journal of radiology
JID - 8106411
RN  - 0 (Stilbenes)
RN  - I5590ES2QZ (fosbretabulin)
SB  - IM
MH  - Animals
MH  - Diffusion Magnetic Resonance Imaging/*methods
MH  - Disease Models, Animal
MH  - Hindlimb
MH  - Infusions, Intravenous
MH  - Neoplasms, Experimental/*drug therapy/*pathology
MH  - Rabbits
MH  - Random Allocation
MH  - Stilbenes/administration & dosage/*pharmacology
EDAT- 2011/04/02 06:00
MHDA- 2012/06/20 06:00
CRDT- 2011/04/02 06:00
PHST- 2011/01/21 00:00 [received]
PHST- 2011/03/02 00:00 [accepted]
PHST- 2011/04/02 06:00 [entrez]
PHST- 2011/04/02 06:00 [pubmed]
PHST- 2012/06/20 06:00 [medline]
AID - S0720-048X(11)00265-8 [pii]
AID - 10.1016/j.ejrad.2011.03.009 [doi]
PST - ppublish
SO  - Eur J Radiol. 2012 Mar;81(3):578-83. doi: 10.1016/j.ejrad.2011.03.009. Epub 2011 
      Mar 30.


PMID- 21454006
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20120126
IS  - 1873-1570 (Electronic)
IS  - 0300-9572 (Linking)
VI  - 82
IP  - 7
DP  - 2011 Jul
TI  - Effects and limitations of an AED with audiovisual feedback for cardiopulmonary
      resuscitation: a randomized manikin study.
PG  - 902-7
LID - 10.1016/j.resuscitation.2011.02.023 [doi]
AB  - PURPOSE: Correctly performed basic life support (BLS) and early defibrillation
      are the most effective measures to treat sudden cardiac arrest. Audiovisual
      feedback improves BLS. Automated external defibrillators (AED) with feedback
      technology may play an important role in improving CPR quality. The aim of this
      simulation study was to investigate if an AED with audiovisual feedback improves 
      CPR parameters during standard BLS performed by trained laypersons. METHODS: With
      ethics committee approval and informed consent, 68 teams (2 flight attendants
      each) performed 12 min of standard CPR with the AED's audiovisual feedback
      mechanism enabled or disabled. We recorded CPR quality parameters during
      resuscitation on a manikin in this open, prospective, randomized controlled
      trial. Between the feedback and control-group we measured differences in
      compression depth and rate as main outcome parameters and effective compressions,
      correct hand position, and incomplete decompression as secondary outcome
      parameters. An effective compression was defined as a compression with correct
      depth, hand position, and decompression. RESULTS: The feedback-group delivered
      compression rates closest to the recommended guidelines (101 +/- 9 vs. 109 +/-
      15/min, p=0.009), more effective compressions (20 +/- 18 vs. 5 +/- 6%, p<0.001), 
      more compressions with correct hand position (96 +/- 13 vs. 88 +/- 16%, p<0.001),
      and less leaning (21 +/- 31 vs. 77 +/- 33%, p<0.001). However, only the
      control-group adhered to the recommended compression depth (44 +/- 7 mm vs. 39
      +/- 6, p=0.003). CONCLUSION: Use of an AED's audiovisual feedback system improved
      some CPR-quality parameters, thus confirming findings of earlier studies with the
      notable exception of decreased compression depth, which is a key parameter that
      might be linked to reduced cardiac output.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Fischer, Henrik
AU  - Fischer H
AD  - Division of Cardio-Thoracic-Vascular Surgical Anaesthesia and Intensive Care
      Medicine Department of Anaesthesia, General Intensive Care and Pain Medicine,
      Medical University, Waehringer Gurtel 18-20, 1090 Vienna, Austria.
FAU - Gruber, Julia
AU  - Gruber J
FAU - Neuhold, Stephanie
AU  - Neuhold S
FAU - Frantal, Sophie
AU  - Frantal S
FAU - Hochbrugger, Eva
AU  - Hochbrugger E
FAU - Herkner, Harald
AU  - Herkner H
FAU - Schochl, Herbert
AU  - Schochl H
FAU - Steinlechner, Barbara
AU  - Steinlechner B
FAU - Greif, Robert
AU  - Greif R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20110331
PL  - Ireland
TA  - Resuscitation
JT  - Resuscitation
JID - 0332173
SB  - IM
CIN - Resuscitation. 2012 Jan;83(1):e9. PMID: 21963819
MH  - Adult
MH  - Cardiopulmonary Resuscitation/*education/methods
MH  - *Defibrillators
MH  - Education, Medical/*methods
MH  - Feedback
MH  - Female
MH  - Humans
MH  - Male
MH  - *Manikins
MH  - Out-of-Hospital Cardiac Arrest/*therapy
MH  - Prospective Studies
EDAT- 2011/04/02 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/04/02 06:00
PHST- 2010/08/05 00:00 [received]
PHST- 2010/11/30 00:00 [revised]
PHST- 2011/02/17 00:00 [accepted]
PHST- 2011/04/02 06:00 [entrez]
PHST- 2011/04/02 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0300-9572(11)00134-1 [pii]
AID - 10.1016/j.resuscitation.2011.02.023 [doi]
PST - ppublish
SO  - Resuscitation. 2011 Jul;82(7):902-7. doi: 10.1016/j.resuscitation.2011.02.023.
      Epub 2011 Mar 31.


PMID- 21453815
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20211020
IS  - 1557-8240 (Electronic)
IS  - 0031-3955 (Linking)
VI  - 58
IP  - 2
DP  - 2011 Apr
TI  - Can food allergy be prevented? The current evidence.
PG  - 481-509, xii
LID - 10.1016/j.pcl.2011.02.002 [doi]
AB  - Food allergy is a recognized public health concern, for which preventative
      strategies are required. Although an intervention that adequately protects
      against the development of food allergy has still to be identified, limited
      benefits have been shown for the prevention of related allergic conditions such
      as eczema, and to a lesser extent asthma and rhinitis; these benefits are usually
      limited to at-risk populations. Prevention strategies need to be tested using
      randomized controlled study designs that account for the numerous methodological 
      challenges, safety concerns, and necessary ethical limitations.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Du Toit, George
AU  - Du Toit G
AD  - Division of Asthma, Allergy and Lung Biology, Guy's and St Thomas' National
      Health Service Foundation Trust, Medical Research Council, London, UK.
      george.dutoit@kcl.ac.uk
FAU - Lack, Gideon
AU  - Lack G
LA  - eng
GR  - MC_G1001205/MRC_/Medical Research Council/United Kingdom
GR  - MC_PC_15020/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Pediatr Clin North Am
JT  - Pediatric clinics of North America
JID - 0401126
RN  - 0 (Prebiotics)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Asthma/immunology/prevention & control
MH  - Breast Feeding
MH  - Child
MH  - Child, Preschool
MH  - Cross Reactions/immunology
MH  - Dietary Supplements
MH  - Eczema/immunology/prevention & control
MH  - Female
MH  - Food Hypersensitivity/immunology/*prevention & control
MH  - Humans
MH  - Immune Tolerance
MH  - Immunoglobulin E/immunology
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Maternal-Fetal Exchange
MH  - Milk Hypersensitivity/prevention & control
MH  - Nutritional Requirements
MH  - Prebiotics
MH  - Pregnancy
MH  - Probiotics
MH  - Randomized Controlled Trials as Topic
MH  - Rhinitis/immunology/prevention & control
EDAT- 2011/04/02 06:00
MHDA- 2011/06/29 06:00
CRDT- 2011/04/02 06:00
PHST- 2011/04/02 06:00 [entrez]
PHST- 2011/04/02 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
AID - S0031-3955(11)00004-6 [pii]
AID - 10.1016/j.pcl.2011.02.002 [doi]
PST - ppublish
SO  - Pediatr Clin North Am. 2011 Apr;58(2):481-509, xii. doi:
      10.1016/j.pcl.2011.02.002.


PMID- 21453543
OWN - NLM
STAT- MEDLINE
DCOM- 20111012
LR  - 20211020
IS  - 1471-2288 (Electronic)
IS  - 1471-2288 (Linking)
VI  - 11
DP  - 2011 Mar 31
TI  - Recruitment difficulties in a primary care cluster randomised trial:
      investigating factors contributing to general practitioners' recruitment of
      patients.
PG  - 35
LID - 10.1186/1471-2288-11-35 [doi]
AB  - BACKGROUND: Recruitment of patients by health professionals is reported as one of
      the most challenging steps when undertaking studies in primary care settings.
      Numerous investigations of the barriers to patient recruitment in trials which
      recruit patients to receive an intervention have been published. However, we are 
      not aware of any studies that have reported on the recruitment barriers as
      perceived by health professionals to recruiting patients into cluster randomised 
      trials where patients do not directly receive an intervention. This particular
      subtype of cluster trial is commonly termed a professional-cluster trial. The aim
      of this study was to investigate factors that contributed to general
      practitioners recruitment of patients in a professional-cluster trial which
      evaluated the effectiveness of an intervention to increase general practitioners 
      adherence to a clinical practice guideline for acute low-back pain. METHOD:
      General practitioners enrolled in the study were posted a questionnaire,
      consisting of quantitative items and an open-ended question, to assess possible
      reasons for poor patient recruitment. Descriptive statistics were used to
      summarise quantitative items and responses to the open-ended question were coded 
      into categories. RESULTS: Seventy-nine general practitioners completed at least
      one item (79/94 = 84%), representing 68 practices (85% practice response rate),
      and 44 provided a response to the open-ended question. General practitioners
      recalled inviting a median of two patients with acute low-back pain to
      participate in the trial over a seven-month period; they reported that they
      intended to recruit patients, but forgot to approach patients to participate; and
      they did not perceive that patients had a strong interest or disinterest in
      participating. Additional open-ended comments were generally consistent with the 
      quantitative data. CONCLUSION: A number of barriers to the recruitment of
      patients with acute low-back pain by general practitioners in a
      professional-cluster trial were identified. These barriers were similar to those 
      that have been identified in the literature surrounding the recruitment of
      patients in individual patient randomised trials. To advance the evidence base
      for patient recruitment strategies in primary care settings, trialists
      undertaking professional-cluster trials need to develop and evaluate patient
      recruitment strategies that minimise the efforts required by practice staff to
      recruit patients, while also meeting privacy and ethical responsibilities and
      minimising the risk of selection bias.
FAU - Page, Matthew J
AU  - Page MJ
AD  - School of Public Health and Preventive Medicine, Monash University, Melbourne,
      Australia. matthew.page@monash.edu
FAU - French, Simon D
AU  - French SD
FAU - McKenzie, Joanne E
AU  - McKenzie JE
FAU - O'Connor, Denise A
AU  - O'Connor DA
FAU - Green, Sally E
AU  - Green SE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110331
PL  - England
TA  - BMC Med Res Methodol
JT  - BMC medical research methodology
JID - 100968545
SB  - IM
MH  - General Practitioners
MH  - *Low Back Pain/epidemiology
MH  - *Patient Selection
MH  - *Randomized Controlled Trials as Topic
MH  - Surveys and Questionnaires
PMC - PMC3076278
EDAT- 2011/04/02 06:00
MHDA- 2011/10/13 06:00
CRDT- 2011/04/02 06:00
PHST- 2010/09/08 00:00 [received]
PHST- 2011/03/31 00:00 [accepted]
PHST- 2011/04/02 06:00 [entrez]
PHST- 2011/04/02 06:00 [pubmed]
PHST- 2011/10/13 06:00 [medline]
AID - 1471-2288-11-35 [pii]
AID - 10.1186/1471-2288-11-35 [doi]
PST - epublish
SO  - BMC Med Res Methodol. 2011 Mar 31;11:35. doi: 10.1186/1471-2288-11-35.


PMID- 21453454
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20220311
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 12
DP  - 2011 Mar 31
TI  - Use of deferred consent for severely ill children in a multi-centre phase III
      trial.
PG  - 90
LID - 10.1186/1745-6215-12-90 [doi]
AB  - BACKGROUND: Voluntary participation of a subject in research respects a subject's
      rights, strengthens its ethical conduct, and is formalized by the informed
      consent process. Clinical trials of life-saving interventions for medical
      emergencies often necessitate enrollment of patients where prior written
      individual informed consent is impossible. Although there are regulations and
      guidelines on protecting subjects in emergency research, these have been
      criticised for being limited and unnecessarily restrictive. Across Europe and the
      United States stringent regulations have resulted in a substantial decline of
      clinical trials involving emergency interventions. METHODS: We are conducting a
      trial of fluid resuscitation in children with hypovolaemic shock in six hospitals
      across three malaria-endemic African countries. The design is pragmatic as
      children are enrolled on clinical criteria alone and is being conducted in
      hospitals with facilities typical of many district hospitals across Africa. The
      trial aims to inform strategy for managing children with febrile illness and
      features of shock. In order to develop appropriate consent processes for the
      trial, we conducted a narrative review of current international recommendations
      for emergency consent. RESULTS: Practical or specific guidance was generally
      sparse or confusing with few examples in the literature to direct our informed
      consent process. For a sub-group of children who were critically sick or where
      parents themselves were otherwise too distressed to consider prior written
      consent, we opted for a modified form of deferred consent. This included verbal
      assent from guardians at the point of enrollment, with full written consent
      obtained after stabilising the child. For children who died prior to full written
      consent, ethical permission was received to waiver full consent. CONCLUSIONS: In 
      light of the controversy around guidance and regulations in this area we report
      how and why we have used a modified system of deferred consent in an emergency
      intervention trial in children. Although approved by all relevant ethics
      committees and operational in 3 countries in Africa, formal research is now
      necessary to explore the perceptions and experiences of parents, health workers, 
      researchers and ethics committees of the modified method of deferred consent.
FAU - Maitland, Kathryn
AU  - Maitland K
AD  - Kemri-Wellcome Centre for Geographic Medicine, Coast, Kenya.
FAU - Molyneux, Sassy
AU  - Molyneux S
FAU - Boga, Mwamvua
AU  - Boga M
FAU - Kiguli, Sarah
AU  - Kiguli S
FAU - Lang, Trudie
AU  - Lang T
LA  - eng
SI  - ISRCTN/ISRCTN69856593
GR  - G0601027/MRC_/Medical Research Council/United Kingdom
GR  - G0801439/MRC_/Medical Research Council/United Kingdom
PT  - Clinical Trial, Phase III
PT  - Journal Article
PT  - Multicenter Study
PT  - Review
DEP - 20110331
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
SB  - IM
MH  - Africa
MH  - Child
MH  - Critical Illness
MH  - *Fluid Therapy
MH  - Humans
MH  - *Informed Consent/ethics
MH  - *Patient Selection/ethics
MH  - Practice Guidelines as Topic
MH  - *Research Design
MH  - Resuscitation/*methods
MH  - Severity of Illness Index
MH  - Shock/*therapy
MH  - *Third-Party Consent/ethics
MH  - Time Factors
MH  - Treatment Outcome
PMC - PMC3077324
EDAT- 2011/04/02 06:00
MHDA- 2011/06/29 06:00
CRDT- 2011/04/02 06:00
PHST- 2010/08/16 00:00 [received]
PHST- 2011/03/31 00:00 [accepted]
PHST- 2011/04/02 06:00 [entrez]
PHST- 2011/04/02 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
AID - 1745-6215-12-90 [pii]
AID - 10.1186/1745-6215-12-90 [doi]
PST - epublish
SO  - Trials. 2011 Mar 31;12:90. doi: 10.1186/1745-6215-12-90.


PMID- 21453451
OWN - NLM
STAT- MEDLINE
DCOM- 20130423
LR  - 20220318
IS  - 1748-5908 (Electronic)
IS  - 1748-5908 (Linking)
VI  - 6
DP  - 2011 Mar 31
TI  - Requirements for ethics committee review for studies submitted to Implementation 
      Science.
PG  - 32
LID - 10.1186/1748-5908-6-32 [doi]
AB  - The requirement for ethics review of studies submitted to Implementation Science 
      has been unclear. Therefore, in this editorial, we set out our requirements for
      ethics committee review of experimental and non-experimental studies. For any
      study that meets the criteria of human subject research (which includes research 
      on healthcare providers), irrespective of study design, we will require proof of 
      either satisfactory ethics committee review or of the granting of an official
      exemption or waiver.
FAU - Eccles, Martin P
AU  - Eccles MP
AD  - Institute of Health & Society, Baddiley-Clark Building, Newcastle upon Tyne, NE2 
      4AX, UK. martin.eccles@ncl.ac.uk
FAU - Weijer, Charles
AU  - Weijer C
FAU - Mittman, Brian
AU  - Mittman B
LA  - eng
PT  - Journal Article
DEP - 20110331
PL  - England
TA  - Implement Sci
JT  - Implementation science : IS
JID - 101258411
SB  - IM
MH  - *Editorial Policies
MH  - Ethics Committees, Research/*standards
MH  - Humans
MH  - Informed Consent/standards
MH  - Periodicals as Topic/*standards
MH  - Quality Improvement/standards
PMC - PMC3076240
GN  - NLM: Original DateCompleted: 20110714
EDAT- 2011/04/02 06:00
MHDA- 2011/04/02 06:01
CRDT- 2011/04/02 06:00
PHST- 2011/03/08 00:00 [received]
PHST- 2011/03/31 00:00 [accepted]
PHST- 2011/04/02 06:00 [entrez]
PHST- 2011/04/02 06:00 [pubmed]
PHST- 2011/04/02 06:01 [medline]
AID - 1748-5908-6-32 [pii]
AID - 10.1186/1748-5908-6-32 [doi]
PST - epublish
SO  - Implement Sci. 2011 Mar 31;6:32. doi: 10.1186/1748-5908-6-32.


PMID- 21453199
OWN - NLM
STAT- MEDLINE
DCOM- 20120229
LR  - 20110722
IS  - 1937-3376 (Electronic)
IS  - 1937-3368 (Linking)
VI  - 17
IP  - 4
DP  - 2011 Aug
TI  - Ethical issues regarding the donation and source of cells for tissue engineering:
      a European focus group study.
PG  - 229-34
LID - 10.1089/ten.TEB.2010.0683 [doi]
AB  - This article is part of the EuroSTEC project, which aims at developing tissue
      engineering-based treatments for structural disorders present at birth. EuroSTEC 
      is positioned at the intersection of three areas with their own ethical issues:
      (1) regenerative medicine, (2) research with pregnant women and fetuses, and (3) 
      research with neonates. Because of the link between these three areas in this
      project, one can expect to be confronted with new ethical challenges. To be able 
      to respond adequately and timely to current and possible future ethical issues, a
      prospective and anticipatory ethical analysis is essential. To obtain a first
      impression of the ethical issues that might arise during the different phases of 
      the project, a Delphi method was used. On the basis of the results of two
      previous rounds of questionnaires, two topics were selected for discussion in
      focus groups: ethical issues associated with (1) source of cells and (2)
      donation. The results could be divided into three clusters: Tissue, Donor, and
      Scientist. Where the former two clusters roughly coincide with the results of the
      previous rounds, the third subject was entirely new but discussed by both groups:
      the role of the scientist in the tissue engineering process.
FAU - Oerlemans, Anke J M
AU  - Oerlemans AJ
AD  - Section Ethics, Philosophy, and History of Medicine, Scientific Institute for
      Quality of Healthcare, Radboud University Nijmegen Medical Centre, Nijmegen, The 
      Netherlands. a.oerlemans@iq.umcn.nl
FAU - van den Berg, Paul P
AU  - van den Berg PP
FAU - van Leeuwen, Evert
AU  - van Leeuwen E
FAU - Dekkers, Wim J M
AU  - Dekkers WJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Tissue Eng Part B Rev
JT  - Tissue engineering. Part B, Reviews
JID - 101466660
SB  - IM
MH  - Cells/*metabolism
MH  - Europe
MH  - Female
MH  - *Focus Groups
MH  - Humans
MH  - Male
MH  - Research Personnel/ethics
MH  - Tissue Donors/*ethics
MH  - Tissue Engineering/*ethics
EDAT- 2011/04/02 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/04/02 06:00
PHST- 2011/04/02 06:00 [entrez]
PHST- 2011/04/02 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - 10.1089/ten.TEB.2010.0683 [doi]
PST - ppublish
SO  - Tissue Eng Part B Rev. 2011 Aug;17(4):229-34. doi: 10.1089/ten.TEB.2010.0683.


PMID- 21448046
OWN - NLM
STAT- MEDLINE
DCOM- 20110420
LR  - 20111006
IS  - 1536-3678 (Electronic)
IS  - 1077-4114 (Linking)
VI  - 33 Suppl 1
DP  - 2011 Apr
TI  - Current status of palliative care in Turkey.
PG  - S78-80
LID - 10.1097/MPH.0b013e3182122470 [doi]
AB  - Patients with cancer are still suffering a lot, especially those in developing
      countries. The concept of palliative care has improved and disseminated slowly in
      Turkey since the early 1990's. It is essential that improved palliative care
      program should be integrated into national health-care systems to control this
      suffering. In this review the history of the development of palliative care,
      opioid availability and some ethical issues in Turkey are reported.
FAU - Komurcu, Seref
AU  - Komurcu S
AD  - Gulhane Medical Academy, Ankara, Turkey. skomurcu@hotmail.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pediatr Hematol Oncol
JT  - Journal of pediatric hematology/oncology
JID - 9505928
RN  - 0 (Analgesics, Opioid)
SB  - IM
MH  - Analgesics, Opioid/therapeutic use
MH  - Ethics, Medical
MH  - National Health Programs/ethics/*organization & administration/*standards/trends
MH  - Palliative Care/ethics/*organization & administration/*standards/trends
MH  - Turkey
EDAT- 2011/04/02 06:00
MHDA- 2011/04/22 06:00
CRDT- 2011/03/31 06:00
PHST- 2011/03/31 06:00 [entrez]
PHST- 2011/04/02 06:00 [pubmed]
PHST- 2011/04/22 06:00 [medline]
AID - 10.1097/MPH.0b013e3182122470 [doi]
AID - 00043426-201104001-00020 [pii]
PST - ppublish
SO  - J Pediatr Hematol Oncol. 2011 Apr;33 Suppl 1:S78-80. doi:
      10.1097/MPH.0b013e3182122470.


PMID- 21448037
OWN - NLM
STAT- MEDLINE
DCOM- 20110420
LR  - 20111006
IS  - 1536-3678 (Electronic)
IS  - 1077-4114 (Linking)
VI  - 33 Suppl 1
DP  - 2011 Apr
TI  - Current status of palliative care in Israel: a pediatric oncologist's
      perspective.
PG  - S56-9
LID - 10.1097/MPH.0b013e3182122047 [doi]
AB  - Pediatric cancer palliative care is characterized by diversity of care delivery
      models; effect of cancer on the family as the central focus of care and
      consideration of culture, spirituality, communication, and ethical standards. In 
      Israel, children who are in palliative care are treated by the staff of the
      centers and about 70 to 80 % of the children are dying in the pediatric
      Hematology Oncology departments and units. Special efforts are also made in the
      pediatric departments in order to better treat adolescents in terminal phases.
      Palliative care education program in Israel was started several years ago
      together with adult palliative care specialists, the Israeli pediatric
      oncologists still witness many barriers for treatment amongst parents as well as 
      in medical pediatric teams especially in pain management. During the last years, 
      the Israeli pediatric palliative care teams improved the management of all
      symptoms in a dying child with special attention to existential, emotional and
      social demands of the child and the whole family. Education of the medical and
      nursing team is imperative, training in pharmacology and metabolism of antalgic
      drugs is also mandatory in order to better manage symptom control of the children
      at the end of life.
FAU - Ben-Arush, Myriam Weyl
AU  - Ben-Arush MW
AD  - Pediatric Hematology Oncology Department, Meyer Children's Hospital, Rambam
      Medical Center, Technion Faculty of Medicine, Bat Galim Street, Haifa, Israel.
      M_benarush@rambam.health.gov.il
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pediatr Hematol Oncol
JT  - Journal of pediatric hematology/oncology
JID - 9505928
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child Health Services/*organization & administration/*standards/trends
MH  - Child, Preschool
MH  - Education, Medical, Continuing/*organization & administration/standards
MH  - Female
MH  - Humans
MH  - Infant
MH  - Israel
MH  - Male
MH  - Neoplasms/*therapy
MH  - Palliative Care/*organization & administration/*standards/trends
EDAT- 2011/04/02 06:00
MHDA- 2011/04/22 06:00
CRDT- 2011/03/31 06:00
PHST- 2011/03/31 06:00 [entrez]
PHST- 2011/04/02 06:00 [pubmed]
PHST- 2011/04/22 06:00 [medline]
AID - 10.1097/MPH.0b013e3182122047 [doi]
AID - 00043426-201104001-00012 [pii]
PST - ppublish
SO  - J Pediatr Hematol Oncol. 2011 Apr;33 Suppl 1:S56-9. doi:
      10.1097/MPH.0b013e3182122047.


PMID- 21452153
OWN - NLM
STAT- MEDLINE
DCOM- 20110809
LR  - 20191112
IS  - 1724-6075 (Electronic)
IS  - 0391-5603 (Linking)
VI  - 78
IP  - 1
DP  - 2011 Jan-Mar
TI  - [Circumcision: history, religion and law].
PG  - 1-9
AB  - The aim of this article is to describe the circumcision procedure during history,
      its therapeutic and preventive goals, with focus on bioethical, economic and law 
      issues. The origins of this practice are lost in antiquity. It was performed
      since 3000 BC by the Egyptians for hygienic and religious reasons. Moreover, male
      circumcision is a religious commandment in Judaism and Islam, and it is customary
      in some Oriental Orthodox and other Christian churches of Africa. Nowadays,
      circumcision is performed as a routine procedure by the Jews and the Muslims for 
      religious reasons. The world prevalence of men with circumcision is 12.5-33%,
      especially in USA, Canada, Islamic people and Africa; in Europe the prevalence
      rate is low (in Great Britain it is 1.5%). Currently, male circumcision is being 
      highly debated because of ethical, law and scientific issues and the different
      roles of this procedure: therapeutic, prophylactic (but there is no universal
      consensus) and ritualistic role. Nowadays, in Italy there is a strong debate
      about the consensus for this practice and its indications. The Italian law does
      not allow performing ritualistic circumcision, as a free of charge procedure in
      public hospitals, at the government's expenses, because the Italian law must
      protect different religious cultures, in name of the laity of the State. Thus,
      national bioethical committee (CNB) has established that ritualistic circumcision
      may only be performed on a paying basis in public hospitals. As a protective
      practice, circumcision has decreased in the entire world because of the
      improvement of hygienical conditions and, above all, the lack of unanimous
      consent on the real usefulness of protective circumcision, even if several
      studies have recently demonstrated the protecting role of male circumcision
      against HIV infection.
FAU - Totaro, Angelo
AU  - Totaro A
AD  - Clinica Urologica, Universita Cattolica del Sacro Cuore, Roma, Italy.
      dr.totaro@gmail.com
FAU - Volpe, Andrea
AU  - Volpe A
FAU - Racioppi, Marco
AU  - Racioppi M
FAU - Pinto, Francesco
AU  - Pinto F
FAU - Sacco, Emilio
AU  - Sacco E
FAU - Bassi, Pier Francesco
AU  - Bassi PF
LA  - ita
PT  - Journal Article
PT  - Review
TT  - La circoncisione tra storia, religione e giurisdizione.
PL  - United States
TA  - Urologia
JT  - Urologia
JID - 0417372
SB  - IM
MH  - Africa
MH  - Americas
MH  - Australia
MH  - Ceremonial Behavior
MH  - Circumcision, Male/adverse effects/*legislation & jurisprudence/statistics &
      numerical data/*trends
MH  - Dissent and Disputes
MH  - Egypt
MH  - Europe
MH  - HIV Infections/prevention & control
MH  - Humans
MH  - Hygiene
MH  - Infant, Newborn
MH  - Italy
MH  - Male
MH  - Penile Neoplasms/prevention & control
MH  - *Religion
EDAT- 2011/04/01 06:00
MHDA- 2011/08/10 06:00
CRDT- 2011/04/01 06:00
PHST- 2010/08/25 00:00 [accepted]
PHST- 2011/04/01 06:00 [entrez]
PHST- 2011/04/01 06:00 [pubmed]
PHST- 2011/08/10 06:00 [medline]
AID - 2B43DD32-5095-43DB-9EDB-34368C272DD3 [pii]
AID - 10.5301/ru.2011.6433 [doi]
PST - ppublish
SO  - Urologia. 2011 Jan-Mar;78(1):1-9. doi: 10.5301/ru.2011.6433.


PMID- 21452145
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20110331
IS  - 0036-7281 (Print)
IS  - 0036-7281 (Linking)
VI  - 153
IP  - 4
DP  - 2011 Apr
TI  - Housing and care of laboratory cats: from requirements to practice.
PG  - 157-64
LID - 10.1024/0036-7281/a000175 [doi]
AB  - Increased public awareness of the welfare and well-being of laboratory animals in
      biomedical research and related ethical considerations inspired us to review
      recent developments and recommendations for the care and housing of laboratory
      cats. The present review focuses on the practical requirements for maintaining
      domestic cats as laboratory animals - from the construction of animal shelters to
      the termination of an experiment. An excellent standard of housing and care will 
      reduce the bias of experimental results due to stress. To provide cats with
      living conditions that best meet their natural physical requirements and permit
      natural social behaviour, laboratories should spare no effort to achieve high
      housing standards. Hence, the present report not only aims to be a practical
      reference for those who are involved in the care and husbandry of cats, but it
      also aims to motivate researchers to improve their knowledge in this field and to
      provide humane conditions for all cats kept for scientific purposes.
FAU - Geret, C
AU  - Geret C
AD  - Clinical Laboratory, University of Zurich, Switzerland.
FAU - Riond, B
AU  - Riond B
FAU - Cattori, V
AU  - Cattori V
FAU - Meli, M
AU  - Meli M
FAU - Hofmann-Lehmann, R
AU  - Hofmann-Lehmann R
FAU - Lutz, H
AU  - Lutz H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Switzerland
TA  - Schweiz Arch Tierheilkd
JT  - Schweizer Archiv fur Tierheilkunde
JID - 0424247
SB  - IM
MH  - Animal Husbandry/*standards
MH  - Animal Welfare/*standards
MH  - Animals
MH  - *Animals, Laboratory
MH  - Cats/*physiology/psychology
MH  - Housing, Animal/standards
EDAT- 2011/04/01 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/04/01 06:00
PHST- 2011/04/01 06:00 [entrez]
PHST- 2011/04/01 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - 10.1024/0036-7281/a000175 [doi]
PST - ppublish
SO  - Schweiz Arch Tierheilkd. 2011 Apr;153(4):157-64. doi: 10.1024/0036-7281/a000175.


PMID- 21451262
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20190516
IS  - 1554-8619 (Electronic)
IS  - 1554-8600 (Linking)
VI  - 7
IP  - 4
DP  - 2011 Apr
TI  - Provenge: revolutionary technology or ethical bust?
PG  - 477-80
AB  - Sipuleucel-T (known by the trade name, "Provenge") is the first prostate cancer
      vaccine approved by the Food and Drug Administration (FDA), and represents a new 
      type of cancer therapy termed, Autologous Cellular Immunotherapy (ACT). This
      therapy has been described as a revolution in technology by clinicians and
      researchers alike. However, policy-makers and health economists question the
      efficacy of such treatment given its costs, while mainstream media often bemoan
      Provenge as yet another example of a healthcare system gone awry. This paper
      examines the debate for and against Provenge, and discusses why Medicare adoption
      of payment protocols for the vaccine may violate the egalitarian and feminist
      principles of distributive justice theory. The paper also acknowledges the larger
      context of the Provenge debate within the bioethical community; that is, how much
      should society be willing to invest to prevent death? The paper concludes by
      arguing for a more thorough ethical review of such new technologies by
      policy-makers prior to the adoption of funding protocols.
FAU - Dickerson, Justin B
AU  - Dickerson JB
AD  - Department of Health Policy & Management; School of Rural Public Health; Texas
      A&M Health Science Center; College Station, TX, USA. dickerson@srph.tamhsc.edu
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110401
PL  - United States
TA  - Hum Vaccin
JT  - Human vaccines
JID - 101265291
RN  - 0 (Cancer Vaccines)
RN  - 0 (Tissue Extracts)
RN  - 8Q622VDR18 (sipuleucel-T)
SB  - IM
MH  - Cancer Vaccines/*economics/*therapeutic use
MH  - Humans
MH  - Immunotherapy/*economics/*ethics/methods
MH  - Male
MH  - Prostatic Neoplasms/immunology/*therapy
MH  - Tissue Extracts/*economics/*therapeutic use
EDAT- 2011/04/01 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/04/01 06:00
PHST- 2011/04/01 06:00 [entrez]
PHST- 2011/04/01 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - 14189 [pii]
AID - 10.4161/hv.7.4.14189 [doi]
PST - ppublish
SO  - Hum Vaccin. 2011 Apr;7(4):477-80. doi: 10.4161/hv.7.4.14189. Epub 2011 Apr 1.


PMID- 21450748
OWN - NLM
STAT- MEDLINE
DCOM- 20120103
LR  - 20120730
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 7
DP  - 2011 Jul
TI  - Infant homicide and accidental death in the United States, 1940-2005: ethics and 
      epidemiological classification.
PG  - 445-8
LID - 10.1136/jme.2010.041053 [doi]
AB  - Potential ethical issues can arise during the process of epidemiological
      classification. For example, unnatural infant deaths are classified as accidental
      deaths or homicides. Societal sensitivity to the physical abuse and neglect of
      children has increased over recent decades. This enhanced sensitivity could
      impact reported infant homicide rates. Infant homicide and accident mortality
      rates in boys and girls in the USA from 1940 to 2005 were analysed. In 1940,
      infant accident mortality rates were over 20 times greater than infant homicide
      rates in both boys and girls. After about 1980, when the ratio of infant accident
      mortality rates to infant homicide rates decreased to less than five, and the sum
      of infant accident and homicide rates became relatively constant, further
      decreases in infant accident mortality rates were associated with increases in
      reported infant homicide rates. These findings suggest that the dramatic decline 
      of accidental infant mortality and recent increased societal sensitivity to child
      abuse may be related to the increased infant homicide rates observed in the USA
      since 1980 rather than an actual increase in societal violence directed against
      infants. Ethical consequences of epidemiological classification, involving the
      principles of beneficence, non-maleficence and justice, are suggested by observed
      patterns in infant accidental deaths and homicides in the USA from 1940 to 2005.
FAU - Riggs, Jack E
AU  - Riggs JE
AD  - Department of Neurology, West Virginia University, Morgantown, WV 26506-9180,
      USA. jriggs@wvu.edu
FAU - Hobbs, Gerald R
AU  - Hobbs GR
LA  - eng
PT  - Journal Article
DEP - 20110330
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Accidents/*mortality/statistics & numerical data
MH  - Cause of Death
MH  - Female
MH  - Homicide/*statistics & numerical data
MH  - Humans
MH  - Infant
MH  - Infant Mortality
MH  - Male
MH  - Risk Factors
MH  - United States/epidemiology
EDAT- 2011/04/01 06:00
MHDA- 2012/01/04 06:00
CRDT- 2011/04/01 06:00
PHST- 2011/04/01 06:00 [entrez]
PHST- 2011/04/01 06:00 [pubmed]
PHST- 2012/01/04 06:00 [medline]
AID - jme.2010.041053 [pii]
AID - 10.1136/jme.2010.041053 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Jul;37(7):445-8. doi: 10.1136/jme.2010.041053. Epub 2011 Mar
      30.


PMID- 21450747
OWN - NLM
STAT- MEDLINE
DCOM- 20120224
LR  - 20110822
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 9
DP  - 2011 Sep
TI  - Bioethics in a clinic for women with psychosis.
PG  - 518-22
LID - 10.1136/jme.2010.042069 [doi]
AB  - Clinical ethics takes on a special cast in a rehabilitation clinic for psychosis 
      where many patients come from severely disadvantaged backgrounds and many suffer 
      from fluctuating decisional capacity. This paper illustrates several ethical
      issues-truth telling and partiality, prescribing concealed medication,
      questionable billing practices, industry collaboration, limits of
      confidentiality, grounds for abandonment and the primacy of autonomy-in the hope 
      that discussing such matters will lead to a clearer framework for work with this 
      population.
FAU - Seeman, Mary V
AU  - Seeman MV
AD  - Departmentof Psychiatry, University of Toronto, Toronto, Canada.
      mary.seeman@utoronto.ca
FAU - Seeman, Bob
AU  - Seeman B
LA  - eng
PT  - Journal Article
DEP - 20110330
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Bioethics
MH  - Community-Institutional Relations
MH  - Confidentiality/ethics
MH  - Cooperative Behavior
MH  - Drug Industry/trends
MH  - Empathy/ethics
MH  - *Ethics, Clinical
MH  - Ethics, Medical
MH  - Ethics, Professional
MH  - Female
MH  - Health Care Costs/ethics
MH  - Humans
MH  - Moral Obligations
MH  - Patient Rights/ethics
MH  - Professional Autonomy
MH  - Psychotic Disorders/*rehabilitation
MH  - Refusal to Treat/ethics
MH  - Truth Disclosure/*ethics
MH  - Women
EDAT- 2011/04/01 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/04/01 06:00
PHST- 2011/04/01 06:00 [entrez]
PHST- 2011/04/01 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - jme.2010.042069 [pii]
AID - 10.1136/jme.2010.042069 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Sep;37(9):518-22. doi: 10.1136/jme.2010.042069. Epub 2011 Mar 
      30.


PMID- 21450745
OWN - NLM
STAT- MEDLINE
DCOM- 20120224
LR  - 20110822
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 9
DP  - 2011 Sep
TI  - Rethinking paternalism: an exploration of responses to the Israel Patient's
      Rights Act 1996.
PG  - 540-3
LID - 10.1136/jme.2010.042101 [doi]
AB  - Questions of patient autonomy have formed an important part of ethical debate in 
      medicine from at least the post-war period onwards. Although initially important 
      as a counterweight to widespread medical paternalism, recent years have seen a
      reaction against a widely perceived 'triumph of autonomy'. In particular,
      competent patients' refusal of life-saving or clearly beneficial treatment
      presents complex dilemmas for both healthcare professionals and ethicists.
      Discussion of the mechanism provided by the Israel Patient's Rights Act of 1996
      for ethics committees to override refusal of treatment by such patients has
      provided several examples in which it seems an obligation to benefit the patient 
      can outweigh concerns regarding respect for their autonomy. However, such
      analyses as have been undertaken so far may be seen to omit important elements of
      the moral decision-making process that takes place even when the latter appears
      to 'win out'. In addition to helping better prepare clinicians to meet such
      challenges in the future, a fuller appreciation of those elements that are
      present in justified cases of coercive treatment may enable them to arrive at a
      better understanding of what autonomy itself can mean in a medical context.
FAU - Waltho, Simon
AU  - Waltho S
AD  - walthos1@cardiff.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20110330
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Beneficence
MH  - Coercion
MH  - Decision Making/ethics
MH  - Ethics, Medical
MH  - Humans
MH  - Informed Consent/ethics
MH  - Israel
MH  - Jurisprudence
MH  - Morals
MH  - Paternalism/*ethics
MH  - Patient Rights/*ethics
MH  - Personal Autonomy
MH  - Treatment Refusal/ethics
EDAT- 2011/04/01 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/04/01 06:00
PHST- 2011/04/01 06:00 [entrez]
PHST- 2011/04/01 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - jme.2010.042101 [pii]
AID - 10.1136/jme.2010.042101 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Sep;37(9):540-3. doi: 10.1136/jme.2010.042101. Epub 2011 Mar
      30.


PMID- 21450483
OWN - NLM
STAT- MEDLINE
DCOM- 20120306
LR  - 20111017
IS  - 1873-734X (Electronic)
IS  - 1010-7940 (Linking)
VI  - 40
IP  - 5
DP  - 2011 Nov
TI  - Mortality meetings: ethical considerations and adherence to evidence-based
      practice from 6 years of experience in a mixed cardiac department.
PG  - 1039-45
LID - 10.1016/j.ejcts.2011.02.050 [doi]
AB  - OBJECTIVE: Most patients die unexpectedly in cardiac departments. We analyzed the
      ethical issues raised by poor outcomes and the leading causes of hospital deaths 
      including organic causes of deaths, system failures, and questionable caregivers'
      attitudes. METHOD: We analyzed reports from 99 mortality conferences in a mixed
      cardiac department (surgery and interventional cardiology) where 146 patients
      died from 2002 to 2008. RESULTS: Patients were referred for cardiac surgery
      (n=115), interventional cardiology (n=25), or medical therapy (n=11). Highly
      recommended class I interventions were performed in most patients (n=120, 82%). A
      history of renal failure (25%), peripheral artery disease (21%), diabetes (18%), 
      cancer (16%), or respiratory disease (16%) was frequently noticed. The areas most
      frequently identified as potentially problematic were preoperative strategy
      (58%), surgical technique (50%), monitoring (47%), reactivity (43%), drug
      prescription (32%), difficulties or delays in diagnosis (27%), and transfer
      (21%). At least one transgression from routine medical practice was identified in
      66 (45%) patients, and a causal relationship between this transgression and the
      patient's death was suggested in 33 cases (23%). Serious errors were identified
      for five patients (3%), with a suggested causal relationship to death in two
      cases. Ethical discussions focused on alternatives in treatment (73%), good
      medical practice (44%), secondary recommendations (18%), information (12%),
      consent (12%), non-malfeasance (7%), and equity (6%). CONCLUSIONS: Mortality
      conferences provide an opportunity to identify many system failures. Poor outcome
      is multifactorial. Technical and ethical aspects should be considered for quality
      care improvement.
CI  - Copyright (c) 2011 European Association for Cardio-Thoracic Surgery. Published by
      Elsevier B.V. All rights reserved.
FAU - Larrazet, Fabrice
AU  - Larrazet F
AD  - Hopital Saint Camille, 2 rue des Peres Camilliens, 94366 Bry sur Marne, France.
      f.larrazet@ch-bry.org
FAU - Folliguet, Thierry
AU  - Folliguet T
FAU - Laborde, Francois
AU  - Laborde F
FAU - Bachet, Jean
AU  - Bachet J
FAU - Herve, Christian
AU  - Herve C
LA  - eng
PT  - Journal Article
DEP - 20110329
PL  - Germany
TA  - Eur J Cardiothorac Surg
JT  - European journal of cardio-thoracic surgery : official journal of the European
      Association for Cardio-thoracic Surgery
JID - 8804069
SB  - IM
CIN - Eur J Cardiothorac Surg. 2011 Nov;40(5):1045-6. PMID: 21543234
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Attitude of Health Personnel
MH  - Cardiac Surgical Procedures/ethics/*mortality/standards
MH  - Cardiology Service, Hospital/ethics/*standards
MH  - Cardiovascular Diseases/*mortality/*therapy
MH  - Clinical Competence
MH  - Comorbidity
MH  - Cross Infection/mortality
MH  - Epidemiologic Methods
MH  - Ethics, Medical
MH  - Evidence-Based Medicine/methods
MH  - Female
MH  - France/epidemiology
MH  - Health Services Research
MH  - Humans
MH  - Male
MH  - Medical Audit/ethics/*organization & administration
MH  - Middle Aged
MH  - Young Adult
EDAT- 2011/04/01 06:00
MHDA- 2012/03/07 06:00
CRDT- 2011/04/01 06:00
PHST- 2011/01/06 00:00 [received]
PHST- 2011/02/17 00:00 [revised]
PHST- 2011/02/21 00:00 [accepted]
PHST- 2011/04/01 06:00 [entrez]
PHST- 2011/04/01 06:00 [pubmed]
PHST- 2012/03/07 06:00 [medline]
AID - S1010-7940(11)00252-1 [pii]
AID - 10.1016/j.ejcts.2011.02.050 [doi]
PST - ppublish
SO  - Eur J Cardiothorac Surg. 2011 Nov;40(5):1039-45. doi:
      10.1016/j.ejcts.2011.02.050. Epub 2011 Mar 29.


PMID- 21450424
OWN - NLM
STAT- MEDLINE
DCOM- 20111103
LR  - 20110628
IS  - 1872-6283 (Electronic)
IS  - 0379-0738 (Linking)
VI  - 210
IP  - 1-3
DP  - 2011 Jul 15
TI  - Combined chemical and optical methods for monitoring the early decay stages of
      surrogate human models.
PG  - 154-63
LID - 10.1016/j.forsciint.2011.02.023 [doi]
AB  - As the body decays shortly after death, a variety of gases and volatile organic
      compounds (VOCs) constantly emanate. Ethical and practical reasons limit the use 
      of human corpses in controlled, time-dependent, intervening experiments for
      monitoring the chemistry of body decay. Therefore the utilization of pig
      carcasses serves as a potential surrogate to human models. The aim of this work
      was to study buried body decay in conditions of entrapment in collapsed
      buildings. Six domestic pigs were used to study carcass decay. They were enclosed
      in plastic body bags after being partially buried with rubbles, resembling
      entrapment in collapsed buildings. Three experimental cycles were performed,
      employing two pig carcasses in each cycle; VOCs and inorganic gases were measured
      daily, along with daily visible and thermal images. VOCs were collected in
      standard sorbent tubes and subsequently analyzed using a Thermal Desorption/Gas
      Chromatograph/high sensitivity bench-top Time-of-Flight Mass Spectrometer
      (TD/GC/TOF-MS). A comprehensive, stage by stage, detailed information on the
      decay process is being presented based on the experimental macroscopic
      observations, justifying thus the use of pig carcasses as surrogate material. A
      variety of VOCs were identified including almost all chemical classes: sulfur,
      nitrogen, oxygen compounds (aldehydes, alcohols, ketones, acids and esters),
      hydrocarbons, fluorides and chlorides. Carcasses obtained from a pig farm
      resulted in more sulfur and nitrogen cadaveric volatiles. Carbon dioxide was by
      far the most abundant inorganic gas identified along with carbon monoxide,
      hydrogen sulfide and sulfur dioxide. Visual monitoring was based on video
      captured images allowing for macroscopic observations, while thermal camera
      monitoring which is mostly temperature dependent, resulted in highlighting the
      local micro-changes on the carcasses, as a result of the intense microbial
      activity. The combination of chemical and optical methods proved very useful and 
      informative, uncovering hidden aspects of the early stages of decay and also
      guiding in the development of combined chemical and imaging methods for the
      detection of dead bodies.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Statheropoulos, M
AU  - Statheropoulos M
AD  - School of Chemical Engineering, National Technical University of Athens (NTUA),
      Field Analytical Chemistry and Technology Unit, 9 Iroon Polytechniou Str., 157 73
      Athens, Greece.
FAU - Agapiou, A
AU  - Agapiou A
FAU - Zorba, E
AU  - Zorba E
FAU - Mikedi, K
AU  - Mikedi K
FAU - Karma, S
AU  - Karma S
FAU - Pallis, G C
AU  - Pallis GC
FAU - Eliopoulos, C
AU  - Eliopoulos C
FAU - Spiliopoulou, C
AU  - Spiliopoulou C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110330
PL  - Ireland
TA  - Forensic Sci Int
JT  - Forensic science international
JID - 7902034
RN  - 0 (Gases)
RN  - 0 (Volatile Organic Compounds)
SB  - IM
MH  - Animals
MH  - Body Temperature
MH  - Burial
MH  - Confined Spaces
MH  - Forensic Pathology
MH  - Gas Chromatography-Mass Spectrometry
MH  - Gases/*analysis
MH  - Humans
MH  - *Models, Animal
MH  - *Postmortem Changes
MH  - Swine
MH  - Time Factors
MH  - Videotape Recording
MH  - Volatile Organic Compounds/*analysis
EDAT- 2011/04/01 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/04/01 06:00
PHST- 2010/07/04 00:00 [received]
PHST- 2011/02/02 00:00 [revised]
PHST- 2011/02/28 00:00 [accepted]
PHST- 2011/04/01 06:00 [entrez]
PHST- 2011/04/01 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
AID - S0379-0738(11)00109-5 [pii]
AID - 10.1016/j.forsciint.2011.02.023 [doi]
PST - ppublish
SO  - Forensic Sci Int. 2011 Jul 15;210(1-3):154-63. doi:
      10.1016/j.forsciint.2011.02.023. Epub 2011 Mar 30.


PMID- 21450237
OWN - NLM
STAT- MEDLINE
DCOM- 20120511
LR  - 20120102
IS  - 1538-9375 (Electronic)
IS  - 1525-8610 (Linking)
VI  - 13
IP  - 1
DP  - 2012 Jan
TI  - End-of-life care of the geriatric patient and nurses' moral distress.
PG  - 80.e7-13
LID - 10.1016/j.jamda.2010.12.014 [doi]
AB  - OBJECTIVES: Moral distress (MD) occurs when the health care provider feels
      certain of the ethical course of action but is constrained from taking that
      action. The purpose was to examine MD in geriatric nursing care and to identify
      factors related to MD. DESIGN: Cross-sectional survey. SETTING: Twenty nursing
      homes and 3 acute geriatric wards in Flanders (Belgium). PARTICIPANTS:
      Participants were 222 nurses providing geriatric care. MEASUREMENTS: Moral
      distress was assessed with an 18-item questionnaire, adapted from the Moral
      Distress Scale. Multivariate linear regression analysis was used to identify key 
      factors (situational, work, and personal factors) related to MD. RESULTS: The
      response rate was 57%. The frequency score of MD was 1.1 (mean, range 0-4) and
      the intensity score of MD was 2.3 (mean, range 0-4). Nurses identified situations
      involving unjustifiable life support (mean product score MPS 4.8), unnecessary
      tests and treatments (MPS 4.4), and working with incompetent colleagues (MPS 4.3)
      as causing the most MD. Responding to requests for euthanasia (MPS 0.8) and
      increasing morphine in an unconscious patient believed to hasten death (MPS 1.2) 
      were least likely to cause MD. The total MD score (sum of the 18 product scores) 
      was significantly higher in nurses with intentional or actual job-leave (mean
      difference = 15.1, t = -3.5, P = .001). After adjusting for demographic factors, 
      the following factors were independently associated with elevated MD: working in 
      an acute geriatric care setting (as compared with the chronic geriatric care
      setting), a lack of involvement in end-of-life decisions, a lack of ethical
      debate, and specific measures of burnout (emotional exhaustion and personal
      accomplishment). CONCLUSION: Providing futile and inadequate care contributes to 
      moral distress more than euthanasia and believing to hasten an unconscious
      patient's death by increasing morphine in geriatric end-of-life care. Nurses'
      moral distress is related to situational and work characteristics as well as to
      burnout and job-leave.
CI  - Copyright (c) 2012 American Medical Directors Association, Inc. Published by
      Elsevier Inc. All rights reserved.
FAU - Piers, Ruth D
AU  - Piers RD
AD  - Department of Geriatrics, Ghent University Hospital, Ghent, Belgium.
      ruth.piers@ugent.be
FAU - Van den Eynde, Magali
AU  - Van den Eynde M
FAU - Steeman, Els
AU  - Steeman E
FAU - Vlerick, Peter
AU  - Vlerick P
FAU - Benoit, Dominique D
AU  - Benoit DD
FAU - Van Den Noortgate, Nele J
AU  - Van Den Noortgate NJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110211
PL  - United States
TA  - J Am Med Dir Assoc
JT  - Journal of the American Medical Directors Association
JID - 100893243
SB  - IM
MH  - Adult
MH  - Belgium
MH  - Cross-Sectional Studies
MH  - Female
MH  - *Geriatric Nursing
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - *Morals
MH  - Nurses/*psychology
MH  - Nursing Homes
MH  - Terminal Care/*ethics
MH  - Young Adult
EDAT- 2011/04/01 06:00
MHDA- 2012/05/12 06:00
CRDT- 2011/04/01 06:00
PHST- 2010/11/03 00:00 [received]
PHST- 2010/12/15 00:00 [revised]
PHST- 2010/12/15 00:00 [accepted]
PHST- 2011/04/01 06:00 [entrez]
PHST- 2011/04/01 06:00 [pubmed]
PHST- 2012/05/12 06:00 [medline]
AID - S1525-8610(10)00429-9 [pii]
AID - 10.1016/j.jamda.2010.12.014 [doi]
PST - ppublish
SO  - J Am Med Dir Assoc. 2012 Jan;13(1):80.e7-13. doi: 10.1016/j.jamda.2010.12.014.
      Epub 2011 Feb 11.


PMID- 21450153
OWN - NLM
STAT- MEDLINE
DCOM- 20110531
LR  - 20211020
IS  - 1555-2101 (Electronic)
IS  - 0160-6689 (Linking)
VI  - 72
IP  - 3
DP  - 2011 Mar
TI  - Evolution of psychopharmacology trial design and analysis: six decades in the
      making.
PG  - 331-40
LID - 10.4088/JCP.10r06669 [doi]
AB  - OBJECTIVE: The evolution of trial design and analysis during the lifespan of
      psychopharmacology is examined. BACKGROUND: The clinical trial methodology used
      to evaluate psychopharmacologic agents has evolved considerably over the past 6
      decades. The first and most productive decade was characterized by case series,
      each with a small number of patients. These trials used nonstandardized clinical 
      observation as outcomes and seldom had a comparison group. The crossover design
      became widely used to examine acute psychiatric treatments in the 1950s and
      1960s. Although this strategy provided comparison data, it introduced problems in
      study implementation and interpretation. In 1962, the US Food and Drug
      Administration began to require "substantial evidence of effectiveness from
      adequate and well-controlled studies." Subsequent decades saw remarkable advances
      in clinical trial design, assessment, and statistical analyses. Standardized
      instruments were developed and parallel groups, double-blinding, and placebo
      controls became the benchmark. Sample sizes increased and data analytic
      procedures were developed that could accommodate the problems of attrition.
      Randomized withdrawal designs were introduced in the 1970s to examine maintenance
      therapies. Ethical principles for research became codified in the United States
      at that time. A wave of regulatory approvals of novel antipsychotics,
      antidepressants, and anticonvulsants came in the 1980s and 1990s, each based on
      data from randomized double-blind, parallel-group, placebo-controlled clinical
      trials. These trial designs often involved fixed-dose comparisons based, in part,
      on a greater appreciation that much of the benefit and harm in psychopharmacology
      was dose related. CONCLUSIONS: Despite the progress in randomized controlled
      trial (RCT) design, the discovery of new mechanisms of action and blockbuster
      interventions has slowed during the past decade.
CI  - (c) Copyright 2011 Physicians Postgraduate Press, Inc.
FAU - Leon, Andrew C
AU  - Leon AC
AD  - Weill Cornell Medical College, Department of Psychiatry, Box 140, 525 East 68th
      St, New York, NY 10065, USA. acleon@med.cornell.edu
LA  - eng
GR  - RC4 MH092606-01/MH/NIMH NIH HHS/United States
GR  - P30 MH085943-03/MH/NIMH NIH HHS/United States
GR  - MH068638/MH/NIMH NIH HHS/United States
GR  - R01 MH060447/MH/NIMH NIH HHS/United States
GR  - RC4 MH092606/MH/NIMH NIH HHS/United States
GR  - MH092606/MH/NIMH NIH HHS/United States
GR  - P30 MH068638/MH/NIMH NIH HHS/United States
GR  - P30 MH085943/MH/NIMH NIH HHS/United States
GR  - R01 MH060447-07/MH/NIMH NIH HHS/United States
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Clin Psychiatry
JT  - The Journal of clinical psychiatry
JID - 7801243
RN  - 0 (Placebos)
RN  - 0 (Psychotropic Drugs)
SB  - IM
CIN - J Clin Psychiatry. 2011 Aug;72(8):1156-7, author reply 1157. PMID: 21899821
CIN - J Clin Psychiatry. 2012 Feb;73(2):e257-63. PMID: 22401486
MH  - Clinical Trials as Topic/*history/methods
MH  - Data Interpretation, Statistical
MH  - Double-Blind Method
MH  - Drug Evaluation/history
MH  - Guidelines as Topic
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Mental Disorders/drug therapy
MH  - Placebos/history
MH  - Psychopharmacology/*history
MH  - Psychotropic Drugs/history/therapeutic use
MH  - Randomized Controlled Trials as Topic/history/methods
MH  - Sample Size
MH  - United States
PMC - PMC3088431
MID - NIHMS292774
EDAT- 2011/04/01 06:00
MHDA- 2011/06/01 06:00
CRDT- 2011/04/01 06:00
PHST- 2010/10/28 00:00 [received]
PHST- 2010/12/09 00:00 [accepted]
PHST- 2011/04/01 06:00 [entrez]
PHST- 2011/04/01 06:00 [pubmed]
PHST- 2011/06/01 06:00 [medline]
AID - 10.4088/JCP.10r06669 [doi]
PST - ppublish
SO  - J Clin Psychiatry. 2011 Mar;72(3):331-40. doi: 10.4088/JCP.10r06669.


PMID- 21449986
OWN - NLM
STAT- MEDLINE
DCOM- 20111109
LR  - 20151119
IS  - 1365-2648 (Electronic)
IS  - 0309-2402 (Linking)
VI  - 67
IP  - 9
DP  - 2011 Sep
TI  - Nurses' perceptions of individualized care: an international comparison.
PG  - 1895-907
LID - 10.1111/j.1365-2648.2011.05626.x [doi]
AB  - AIM: This paper is a report of a study of internationally-based differences in
      nurses' perceptions of individualized care in orthopaedic surgical in-patient
      wards. BACKGROUND: Individualized care is valued in healthcare policy, practice
      and ethical statements as an indicator of care quality. However, nurses'
      assessments of individualized care are limited and comparative cross-cultural
      studies on individualized nursing care are lacking. METHODS: A descriptive
      comparative survey was used to sample orthopaedic surgical nurses (n = 1163)
      working in 91 inpatient wards in 34 acute hospitals in Finland, Cyprus, Greece,
      Portugal, Sweden, Turkey and the United States of America. Data were collected
      between March and November 2009 using the Individualized Care Scale-Nurse and
      analysed using descriptive and inferential statistics. RESULTS: Nurses in
      different countries perceived that they supported patients' individuality
      generally and provided individualized care during nursing activities. Although
      the highest scores were in support of patients' individuality in the clinical
      situation both through nursing provision and nurses' perceptions of
      individuality, there were between-country differences within these scores.
      Generally, the Greek and American nurses gave the highest scores and the Turkish,
      Cypriot and Portuguese nurses the lowest. CONCLUSIONS: Between-country
      differences found may be attributed to differing roles of nurses, care processes,
      healthcare systems and/or the ways nursing care is defined and organized. As this
      was the first time the Individualized Care Scale-Nurse was used in an
      international context, the results are formative and indicate the need to
      continue studies in this area.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Suhonen, Riitta
AU  - Suhonen R
AD  - Principal Investigator Department of Nursing Science, University of Turku,
      Finland. suhonen.riitta@kolumbus.fi
FAU - Papastavrou, Evridiki
AU  - Papastavrou E
FAU - Efstathiou, Georgios
AU  - Efstathiou G
FAU - Lemonidou, Chryssoula
AU  - Lemonidou C
FAU - Kalafati, Maria
AU  - Kalafati M
FAU - da Luz, Maria Deolinda Antunes
AU  - da Luz MD
FAU - Idvall, Ewa
AU  - Idvall E
FAU - Berg, Agneta
AU  - Berg A
FAU - Acaroglu, Rengin
AU  - Acaroglu R
FAU - Sendir, Merdiye
AU  - Sendir M
FAU - Kanan, Nevin
AU  - Kanan N
FAU - Sousa, Valmi D
AU  - Sousa VD
FAU - Katajisto, Jouko
AU  - Katajisto J
FAU - Valimaki, Maritta
AU  - Valimaki M
FAU - Leino-Kilpi, Helena
AU  - Leino-Kilpi H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110330
PL  - England
TA  - J Adv Nurs
JT  - Journal of advanced nursing
JID - 7609811
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - *Attitude of Health Personnel
MH  - Clinical Competence
MH  - *Cross-Cultural Comparison
MH  - Europe
MH  - Female
MH  - Hospital Units/statistics & numerical data
MH  - Humans
MH  - Individuality
MH  - Male
MH  - Nurse's Role/psychology
MH  - Nurse-Patient Relations
MH  - Nursing Methodology Research
MH  - Nursing Staff, Hospital/*psychology/statistics & numerical data
MH  - Orthopedic Procedures/nursing
MH  - *Patient Care Planning
MH  - *Precision Medicine
MH  - Surveys and Questionnaires
MH  - United States
EDAT- 2011/04/01 06:00
MHDA- 2011/11/10 06:00
CRDT- 2011/04/01 06:00
PHST- 2011/04/01 06:00 [entrez]
PHST- 2011/04/01 06:00 [pubmed]
PHST- 2011/11/10 06:00 [medline]
AID - 10.1111/j.1365-2648.2011.05626.x [doi]
PST - ppublish
SO  - J Adv Nurs. 2011 Sep;67(9):1895-907. doi: 10.1111/j.1365-2648.2011.05626.x. Epub 
      2011 Mar 30.


PMID- 21449866
OWN - NLM
STAT- MEDLINE
DCOM- 20110606
LR  - 20201219
IS  - 1326-5377 (Electronic)
IS  - 0025-729X (Linking)
VI  - 194
IP  - 1
DP  - 2011 Jan 3
TI  - Medical merchants: conflict of interest, office product sales and notifiable
      conduct.
PG  - 34-7
AB  - Professional ethical codes identify the issue of conflict of interest, which can 
      distort doctors' objective judgements concerning the best interests of patients. 
      Legal fiduciary duties may be owed by doctors to patients in situations of
      potential conflict of interest. Prescribing and dispensing functions have been
      largely legally separated to prevent conflicts of interest arising. The advent of
      integrative medicine has been accompanied by an apparent growth of in-house
      selling of therapeutic products. Medical merchandising constitutes a prima-facie 
      conflict of interest and may amount to notifiable conduct under the Health
      Practitioner Regulation National Law provisions. We believe that doctors who sell
      therapeutic products should adhere to strict conditions to avoid significantly
      departing from accepted professional standards. Doctors who have a reasonable
      belief that a colleague is failing to comply with these conditions could consider
      notifying the Medical Board of Australia.
FAU - Parker, Malcolm H
AU  - Parker MH
AD  - School of Medicine, University of Queensland, Brisbane, QLD, Australia.
      m.parker@uq.edu.au
FAU - Wardle, Jon L
AU  - Wardle JL
FAU - Weir, Michael
AU  - Weir M
FAU - Stewart, Cameron L
AU  - Stewart CL
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Med J Aust
JT  - The Medical journal of Australia
JID - 0400714
SB  - IM
MH  - Australia
MH  - *Conflict of Interest
MH  - Drug Industry/ethics
MH  - Drug Prescriptions/standards
MH  - *Ethics, Medical
MH  - Humans
MH  - Mandatory Reporting/*ethics
MH  - Marketing/*ethics
MH  - Patient Rights/ethics
MH  - Professional Misconduct/ethics
EDAT- 2011/04/01 06:00
MHDA- 2011/06/07 06:00
CRDT- 2011/04/01 06:00
PHST- 2010/06/07 00:00 [received]
PHST- 2010/10/28 00:00 [accepted]
PHST- 2011/04/01 06:00 [entrez]
PHST- 2011/04/01 06:00 [pubmed]
PHST- 2011/06/07 06:00 [medline]
AID - par10613_fm [pii]
AID - 10.5694/j.1326-5377.2011.tb04143.x [doi]
PST - ppublish
SO  - Med J Aust. 2011 Jan 3;194(1):34-7. doi: 10.5694/j.1326-5377.2011.tb04143.x.


PMID- 21449681
OWN - NLM
STAT- MEDLINE
DCOM- 20110720
LR  - 20181201
IS  - 1744-8042 (Electronic)
IS  - 1462-2416 (Linking)
VI  - 12
IP  - 3
DP  - 2011 Mar
TI  - Use of a comprehensive panel of biomarkers to predict response to a
      fluorouracil-oxaliplatin regimen in patients with metastatic colorectal cancer.
PG  - 433-42
LID - 10.2217/pgs.10.196 [doi]
AB  - AIM: Polymorphisms in the metabolism, detoxification or DNA repair pathways have 
      been proposed as potential predictors of response to 5-fluorouracil and
      oxaliplatin. We have studied the predictive value of a set of germline genetic
      polymorphisms in metastatic colorectal cancer patients treated with mFolfox-6.
      MATERIALS & METHODS: A total of 72 patients, comprising 50 men (69.4%) and 22
      women (30.6%), were included after the signing of an informed consent form.
      Median age was 65.5 years (range: 32-80). All participants received mFolfox-6.
      DNA was extracted from peripheral blood samples and genotyped by direct
      sequencing, SnapShot((R)) and multiplex PCR techniques. Eight polymorphisms
      within six genes were investigated: TS 5 -UTR (variable number tandem repeat +
      G/C), TS 3 -UTR (TS1494del6); MTHFR C677T and A1298C; GSTP1 I105V; ERCC1 C118T;
      XPD Lys751Gln and XRCC1 Arg399Gln. Association was evaluated by univariate
      analysis, and Cox regression and Kaplan-Meier assessed survival. The local ethics
      committee approved the pharmacogenetic study protocol and all subjects signed an 
      informed consent before participating in the study. RESULTS: The sample was in
      Hardy-Weinberg equilibrium. Only XPD Lys751Gln was found to be significantly
      associated with a favorable progression-free survival (PFS). Median PFS for XPD
      Lys751Gln patients (n = 33) was 16 months (95% CI: 9.2-22.7), 10 months (95% CI: 
      6.1-13.9) for Gln/Gln (n = 11) and 8 months (95% CI: 5.8-10.2) for Lys/Lys (n =
      28), p = 0.019. The increased risk of progression was: 1.93 (95% CI: 1.13-13.30; 
      p = 0.017) for Lys/Lys and 2.1 (95% CI: 1.01-4.22; p = 0.047) for Gln/Gln.
      Patients with one or two Val alleles of GSTP1 tended to a lower risk of
      progression compared with Ile/Ile homozygotes, p = 0.067. When XPD Lys751Gln and 
      GSTP1 were analyzed jointly, patients who carried one or two favorable genotypes,
      XPD Lys751Gln and Val, had a longer median PFS: 11 months (95% CI: 7.4-14.6)
      compared with six (95% CI: 4.6-7.4) with unfavorable genotypes, p < 0.001.
      CONCLUSION: In metastatic colorectal cancer patients treated with mFolfox-6, the 
      combination of haplotype XPD Lys751Gln-GSTP1 105Val seems to predict the risk of 
      progression.
FAU - Lamas, Maria J
AU  - Lamas MJ
AD  - Oncology Pharmacy Unit, Complejo Hospitalario Universitario of Santiago (CHUS),
      Choupana S/N, Santiago de Compostela 15706, Spain. mlamasd@yahoo.es
FAU - Duran, Goretti
AU  - Duran G
FAU - Balboa, Emilia
AU  - Balboa E
FAU - Bernardez, Beatriz
AU  - Bernardez B
FAU - Touris, Manuel
AU  - Touris M
FAU - Vidal, Yolanda
AU  - Vidal Y
FAU - Gallardo, Elena
AU  - Gallardo E
FAU - Lopez, Rafael
AU  - Lopez R
FAU - Carracedo, Angel
AU  - Carracedo A
FAU - Barros, Francisco
AU  - Barros F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Pharmacogenomics
JT  - Pharmacogenomics
JID - 100897350
RN  - 0 (Biomarkers, Pharmacological)
RN  - 0 (Organoplatinum Compounds)
RN  - 04ZR38536J (Oxaliplatin)
RN  - U3P01618RT (Fluorouracil)
SB  - IM
CIN - Pharmacogenomics. 2011 Sep;12(9):1243-8. PMID: 21919602
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Antineoplastic Combined Chemotherapy Protocols
MH  - *Biomarkers, Pharmacological
MH  - Colorectal Neoplasms/*drug therapy/*genetics/pathology
MH  - Disease-Free Survival
MH  - Drug Resistance, Neoplasm/*genetics
MH  - Female
MH  - Fluorouracil/*therapeutic use
MH  - Genetic Association Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Organoplatinum Compounds/*therapeutic use
MH  - Oxaliplatin
MH  - Polymorphism, Genetic
EDAT- 2011/04/01 06:00
MHDA- 2011/07/21 06:00
CRDT- 2011/04/01 06:00
PHST- 2011/04/01 06:00 [entrez]
PHST- 2011/04/01 06:00 [pubmed]
PHST- 2011/07/21 06:00 [medline]
AID - 10.2217/pgs.10.196 [doi]
PST - ppublish
SO  - Pharmacogenomics. 2011 Mar;12(3):433-42. doi: 10.2217/pgs.10.196.


PMID- 21449530
OWN - NLM
STAT- MEDLINE
DCOM- 20111102
LR  - 20110627
IS  - 0148-4834 (Print)
IS  - 0148-4834 (Linking)
VI  - 50
IP  - 7
DP  - 2011 Jul
TI  - Facebook: a tool for nursing education research.
PG  - 414-6
LID - 10.3928/01484834-20110331-01 [doi]
AB  - Facebook is an online social networking Web site that allows users to connect
      with other users. Nurse educators can use this technology to advance nursing
      research. Social networks provide new opportunities for locating potential
      research participants and maintaining contact during the research process. The
      purpose of this article is to explain how the researcher used Facebook to locate 
      previous nursing students to ask them to participate in a qualitative study.
      Between 2006 and 2008, 22 nursing students had participated in international
      trips over a 3-year period. Because the students had graduated and moved to other
      geographical areas, the researcher had little or no contact information to use to
      follow-up with them. The researcher used Facebook to locate 18 of the 22 nursing 
      graduates and invite them to participate in a qualitative research study. A
      discussion of the process and the potential ethical issues are provided.
CI  - Copyright 2011, SLACK Incorporated.
FAU - Amerson, Roxanne
AU  - Amerson R
AD  - School of Nursing, Clemson University, Clemson, South Carolina, USA.
      roxanna@clemson.edu
LA  - eng
PT  - Journal Article
DEP - 20110331
PL  - United States
TA  - J Nurs Educ
JT  - The Journal of nursing education
JID - 7705432
SB  - IM
MH  - Humans
MH  - *Internet
MH  - *Nursing Education Research/ethics
MH  - Qualitative Research
MH  - Social Support
EDAT- 2011/04/01 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/04/01 06:00
PHST- 2010/07/21 00:00 [received]
PHST- 2010/10/13 00:00 [accepted]
PHST- 2011/04/01 06:00 [entrez]
PHST- 2011/04/01 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
AID - 10.3928/01484834-20110331-01 [doi]
PST - ppublish
SO  - J Nurs Educ. 2011 Jul;50(7):414-6. doi: 10.3928/01484834-20110331-01. Epub 2011
      Mar 31.


PMID- 21449235
OWN - NLM
STAT- MEDLINE
DCOM- 20110527
LR  - 20211020
IS  - 0022-1058 (Print)
IS  - 0022-1058 (Linking)
VI  - 43
IP  - 1
DP  - 2011 Mar
TI  - The Professor Merry Lecture: Endings and beginnings.
PG  - P17-22
AB  - Organ transplantation has become an established and worthwhile treatment for many
      otherwise intractable conditions in many countries around the world. For example,
      over 4000 patients have benefited from heart or lung transplants (or both) since 
      the first heart transplant in Australia or New Zealand was carried out in 1984.
      However, there is thought to be a worldwide shortage of donors relative to the
      number of organs needed. Many people, notably many of those involved with
      situations in which organ donation might be possible, value the opportunity to
      contribute organs. This has led to interest in expanding the criteria for
      donation. Standard criteria donation (SCD) involves the formal diagnosis of brain
      death, and conservative criteria for donor eligibility. Extended criteria
      donation allows slightly more liberal eligibility criteria, thought acceptable in
      light of improved results in SCD. In donation after cardiac death (DCD), an
      alternative approach to increasing the pool of available donors, a formal
      diagnosis of brain death is not required. The formal diagnosis of brain death is 
      very reliable, but prognosis in less definitive manifestations of severe brain
      damage is less so, as illustrated by numerous anecdotal reports. There is a
      tension between providing enough time between withdrawal of treatment and
      declaration of death for reasonable confidence to be maintained in the process of
      DCD and the desirability of keeping warm ischemic time to a minimum in the
      interest of organ survival. In Australia and New Zealand, DCD is undertaken only 
      in the context of planned withdrawal of support in intensive care units
      (Maastricht category 3). There has been a considered and carefully implemented
      approach to DCD, and the educational initiatives associated with its introduction
      may have had incidental benefit to the SCD program as well. It is, nevertheless, 
      important that all involved are cognizant of the practical and ethical issues at 
      stake.
FAU - Merry, Alan F
AU  - Merry AF
AD  - Department of Anaesthesiology, University of Auckland, Auckland, New Zealand.
      a.merry@auckland.ac.nz
LA  - eng
PT  - Lecture
PL  - United States
TA  - J Extra Corpor Technol
JT  - The journal of extra-corporeal technology
JID - 0267637
MH  - Australia
MH  - *Death
MH  - *Heart Transplantation
MH  - Humans
MH  - New Zealand
MH  - *Tissue Donors
PMC - PMC4680091
EDAT- 2011/04/01 06:00
MHDA- 2011/05/28 06:00
CRDT- 2011/04/01 06:00
PHST- 2011/04/01 06:00 [entrez]
PHST- 2011/04/01 06:00 [pubmed]
PHST- 2011/05/28 06:00 [medline]
PST - ppublish
SO  - J Extra Corpor Technol. 2011 Mar;43(1):P17-22.


PMID- 26069574
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150613
LR  - 20181113
IS  - 1947-6035 (Print)
IS  - 1947-6035 (Linking)
VI  - 2
IP  - 2
DP  - 2011 Apr
TI  - Guidelines for the Design and Conduct of Clinical Studies in Knee Articular
      Cartilage Repair: International Cartilage Repair Society Recommendations Based on
      Current Scientific Evidence and Standards of Clinical Care.
PG  - 100-21
LID - 10.1177/1947603510392913 [doi]
AB  - OBJECTIVE: To summarize current clinical research practice and develop
      methodological standards for objective scientific evaluation of knee cartilage
      repair procedures and products. DESIGN: A comprehensive literature review was
      performed of high-level original studies providing information relevant for the
      design of clinical studies on articular cartilage repair in the knee. Analysis of
      cartilage repair publications and synopses of ongoing trials were used to
      identify important criteria for the design, reporting, and interpretation of
      studies in this field. RESULTS: Current literature reflects the methodological
      limitations of the scientific evidence available for articular cartilage repair. 
      However, clinical trial databases of ongoing trials document a trend suggesting
      improved study designs and clinical evaluation methodology. Based on the current 
      scientific information and standards of clinical care, detailed methodological
      recommendations were developed for the statistical study design, patient
      recruitment, control group considerations, study endpoint definition,
      documentation of results, use of validated patient-reported outcome instruments, 
      and inclusion and exclusion criteria for the design and conduct of scientifically
      sound cartilage repair study protocols. A consensus statement among the
      International Cartilage Repair Society (ICRS) and contributing authors
      experienced in clinical trial design and implementation was achieved.
      CONCLUSIONS: High-quality clinical research methodology is critical for the
      optimal evaluation of current and new cartilage repair technologies. In addition 
      to generally applicable principles for orthopedic study design, specific criteria
      and considerations apply to cartilage repair studies. Systematic application of
      these criteria and considerations can facilitate study designs that are
      scientifically rigorous, ethical, practical, and appropriate for the question(s) 
      being addressed in any given cartilage repair research project.
FAU - Mithoefer, Kai
AU  - Mithoefer K
AD  - Harvard Vanguard Medical Associates, Harvard Medical School, Boston, MA, USA.
FAU - Saris, Daniel B F
AU  - Saris DB
AD  - University Medical Centre, Utrecht, the Netherlands.
FAU - Farr, Jack
AU  - Farr J
AD  - OrthoIndy Knee Care Institute, Indianapolis, IN, USA.
FAU - Kon, Elizaveta
AU  - Kon E
AD  - Rizzoli Orthopedic Institute, Bologna, Italy.
FAU - Zaslav, Kenneth
AU  - Zaslav K
AD  - Virginia Commonwealth University, Richmond, VA, USA.
FAU - Cole, Brian J
AU  - Cole BJ
AD  - Rush University Medical Center, Chicago, IL, USA.
FAU - Ranstam, Jonas
AU  - Ranstam J
AD  - Lund University Hospital, Lund, Sweden.
FAU - Yao, Jian
AU  - Yao J
AD  - Zimmer Orthobiologics, Austin, TX, USA.
FAU - Shive, Matthew
AU  - Shive M
AD  - Biosyntech, Laval, QC, Canada.
FAU - Levine, David
AU  - Levine D
AD  - Genzyme Biosurgery, Cambridge, MA, USA.
FAU - Dalemans, Wilfried
AU  - Dalemans W
AD  - Tigenix, Leuven, Belgium.
FAU - Brittberg, Mats
AU  - Brittberg M
AD  - University of Gothenburg, Kungsbacka, Sweden.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cartilage
JT  - Cartilage
JID - 101518378
PMC - PMC4300780
OTO - NOTNLM
OT  - cartilage repair repair
OT  - clinical trial general
OT  - general
OT  - knee joint involved
OT  - randomized controlled trials diagnostics
OT  - regulatory issues
EDAT- 2011/04/01 00:00
MHDA- 2011/04/01 00:01
CRDT- 2015/06/13 06:00
PHST- 2015/06/13 06:00 [entrez]
PHST- 2011/04/01 00:00 [pubmed]
PHST- 2011/04/01 00:01 [medline]
AID - 10.1177/1947603510392913 [doi]
AID - 10.1177_1947603510392913 [pii]
PST - ppublish
SO  - Cartilage. 2011 Apr;2(2):100-21. doi: 10.1177/1947603510392913.


PMID- 25587251
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150114
LR  - 20220321
IS  - 1680-6433 (Print)
IS  - 1680-6433 (Linking)
VI  - 9
IP  - 2
DP  - 2011 Spring
TI  - Observing principles of medical ethics during family planning services at Tehran 
      urban healthcare centers in 2007.
PG  - 77-82
AB  - BACKGROUND: Family planning has been defined in the framework of mothers and
      children plan as one of Primary Healthcare (PHC) details. Besides quantity, the
      quality of services, particularly in terms of ethics, such as observing
      individuals' privacy, is of great importance in offering family planning
      services. OBJECTIVE: A preliminary study to gather information about the degree
      of medical ethics offered during family planning services at Tehran urban
      healthcare centers. MATERIALS AND METHODS: A questionnaire was designed for
      study. In the first question regarding informed consent, 47 clients who were
      advised about various contraception methods were asked whether advantages and
      disadvantages of the contraceptive methods have been discussed by the service
      provider. Then a certain rank was measured for either client or method in 2007.
      Finally, average value of advantage and disadvantage for each method was
      measured. In questions about autonomy, justice and beneficence, yes/no answers
      have been expected and measured accordingly. RESULTS: Health care providers have 
      stressed more on the advantages of pills and disadvantages of tubectomy and have 
      paid less attention to advantages of injection ampoules and disadvantages of
      pills in first time clients. While they have stressed more on the advantages and 
      disadvantages of tubectomy and less attention to advantages of condom and
      disadvantages of vasectomy in second time clients. Clients divulged their 100%
      satisfaction in terms of observing turns and free charges services. Observance
      degree of autonomy was 64.7% and 77.3% for first time and second- time clients
      respectively. CONCLUSION: Applying the consultant's personal viewpoint for
      selecting a method will breach an informed consent for first and second time
      clients. System has good consideration to justice and no malfeasance.
FAU - Motevallizadeh, Saeed
AU  - Motevallizadeh S
AD  - Research and Technology Deputy, Ministry of Health and Medical Education, Tehran,
      Iran.
FAU - Malek Afzali, Hossein
AU  - Malek Afzali H
AD  - Epidemiology and Biostatistics Department, School of Public Health, Tehran
      University of Medical Sciences, Tehran, Iran.
FAU - Larijani, Bagher
AU  - Larijani B
AD  - Endocrinology and Metabolism Research center, Tehran, Iran.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Reprod Med
JT  - Iranian journal of reproductive medicine
JID - 101463749
PMC - PMC4216439
OTO - NOTNLM
OT  - Client'srights
OT  - Familyplanning
OT  - Principlesofethics
EDAT- 2011/04/01 00:00
MHDA- 2011/04/01 00:01
CRDT- 2015/01/15 06:00
PHST- 2010/06/09 00:00 [received]
PHST- 2010/12/14 00:00 [accepted]
PHST- 2015/01/15 06:00 [entrez]
PHST- 2011/04/01 00:00 [pubmed]
PHST- 2011/04/01 00:01 [medline]
PST - ppublish
SO  - Iran J Reprod Med. 2011 Spring;9(2):77-82.


PMID- 25330560
OWN - HSR
STAT- MEDLINE
DCOM- 20141103
LR  - 20141020
IS  - 1069-0565 (Print)
IS  - 1069-0565 (Linking)
VI  - 20
IP  - 3
DP  - 2011 Spring
TI  - Refractory pain, existential suffering, and palliative care: releasing an
      unbearable lightness of being.
PG  - 469-532
AB  - Since the beginning of the hospice movement in 1967, "total pain management" has 
      been the declared goal of hospice care. Palliating the whole person's physical,
      psychosocial, and spiritual states or conditions is central to managing the pain 
      that induces suffering. At the end-stage of life, an inextricable component of
      the ethics of adjusted care requires recognition of a fundamental right to avoid 
      cruel and unusual suffering from terminal illness. This Article urges wider
      consideration and use of terminal sedation, or sedation until death, as an
      efficacious palliative treatment and as a reasonable medical procedure in order
      to safeguard the "right" to a dignified death. Once the state establishes a human
      right to avoid refractory pain of whatever nature in end-stage illness, a
      coordinate responsibility must be assumed by health care providers to make
      medical judgments consistent with preserving the best interests of a patient's
      quality of life by alleviating suffering. The principle of medical futility is
      the preferred construct for implementing this professional responsibility. Rather
      than continue to be mired in the vexatious quagmire of the doctrine of double
      effect--all in an effort to "test" whether end-stage decisions by health care
      providers are licit or illicit--a relatively simple test of proportionality, or
      cost-benefit analysis, is proffered. Imbedded, necessarily, in this equation is
      the humane virtue of compassion, charity, mercy or agape. Assertions of state
      interest in safeguarding public morality by restricting intimate associational
      freedoms to accelerate death in a terminal illness are suspicious, if, indeed,
      not invalid. No terminally ill individual suffering from either intractable
      somatic or non-somatic pain, or both, should be forced to continue living.
FAU - Smith, George P Jr
AU  - Smith GP Jr
AD  - The Catholic University of America, Washington, D.C., United States.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cornell J Law Public Policy
JT  - Cornell journal of law and public policy
JID - 9892180
RN  - 0 (Hypnotics and Sedatives)
MH  - *Death
MH  - Deep Sedation/*ethics/methods
MH  - Empathy
MH  - Europe
MH  - Euthanasia/*ethics/*legislation & jurisprudence/*psychology
MH  - Hospice Care/trends
MH  - Human Rights
MH  - Humans
MH  - Hypnotics and Sedatives/*administration & dosage/*therapeutic use
MH  - Medical Futility/psychology
MH  - Morals
MH  - Pain Management/*methods
MH  - Pain, Intractable/*psychology/*therapy
MH  - Palliative Care/*ethics/*methods/*psychology
MH  - Personal Autonomy
MH  - Quality of Life
MH  - Right to Die/*ethics/*legislation & jurisprudence
MH  - Stress, Psychological/psychology/therapy
MH  - Suicide, Assisted/ethics/legislation & jurisprudence/psychology
MH  - Terminal Care/*ethics/*methods/*psychology
MH  - Terminally Ill/*legislation & jurisprudence/*psychology
MH  - United States
EDAT- 2011/04/01 00:00
MHDA- 2014/11/05 06:00
CRDT- 2014/10/22 06:00
PHST- 2014/10/22 06:00 [entrez]
PHST- 2011/04/01 00:00 [pubmed]
PHST- 2014/11/05 06:00 [medline]
PST - ppublish
SO  - Cornell J Law Public Policy. 2011 Spring;20(3):469-532.


PMID- 24956427
OWN - NLM
STAT- MEDLINE
DCOM- 20170124
LR  - 20191027
IS  - 1710-2774 (Print)
IS  - 1710-2774 (Linking)
VI  - 14 Spec No 2
DP  - 2011
TI  - Youth justice and mental health in perspective.
PG  - 58-63
AB  - Research indentifies that a significant proportion of youth within the justice
      system possess some form of mental health disorder, and that the presence of an
      emotional disorder can provide important explanatory value regarding the causes
      of crime. Evidence is now overwhelming that services within the youth justice
      system need to account for the causes of crime in order to effectively reduce the
      likelihood of reoffending. Such an ethic within youth justice service delivery
      not only reduces symptoms and risk within the youth and their families but also
      is linked to increasing community safety through reductions in reoffending. This 
      review characterizes the relevance of mental health disorder in considering the
      needs of anti-social youth, and how this appreciation is linked to the delivery
      of effective services as well as what constitutes supportive youth justice
      legislation.
FAU - Leschied, Alan
AU  - Leschied A
AD  - PhD, C Psych, is a psychologist and professor at the University of Western
      Ontario, in London, Ontario. He has been involved in children's services for over
      30 years, providing assessment to the court and developing knowledge in the
      assessment and treatment of youth who are in conflict with their communities,
      involved in the child welfare or involved in the children's mental health
      systems.
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Healthc Q
JT  - Healthcare quarterly (Toronto, Ont.)
JID - 101208192
MH  - Adolescent
MH  - Canada
MH  - Child
MH  - Child Abuse/psychology
MH  - *Criminal Law/legislation & jurisprudence
MH  - Criminals/psychology
MH  - Female
MH  - Humans
MH  - Male
MH  - Mental Disorders/therapy
MH  - *Mental Health/legislation & jurisprudence
MH  - Sex Factors
MH  - Substance-Related Disorders/psychology
EDAT- 2011/04/01 00:00
MHDA- 2017/01/25 06:00
CRDT- 2014/06/24 06:00
PHST- 2014/06/24 06:00 [entrez]
PHST- 2011/04/01 00:00 [pubmed]
PHST- 2017/01/25 06:00 [medline]
AID - 10.12927/hcq.2011.22364 [doi]
PST - ppublish
SO  - Healthc Q. 2011;14 Spec No 2:58-63. doi: 10.12927/hcq.2011.22364.


PMID- 24600534
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 2151-805X (Print)
IS  - 2151-805X (Linking)
VI  - 2
IP  - 2
DP  - 2011 Apr 1
TI  - Need for an Ethical Framework for Testing for Systemic Diseases in Dental
      Clinics.
PG  - 115-136
AB  - Testing for systemic diseases in dental clinics is a potentially attractive
      avenue for oral health professionals and may be viewed as an opportunity to
      increase professional reach, expand practice, and improve financial returns.
      However, several ethical questions arise that must be addressed before such
      activities are adopted. (1) What should be the level of training dentists must
      acquire to deal with challenges associated with testing? (2) How well are dental 
      practices aware of and compliant with the Health Insurance Portability and
      Accountability Act and procedures related to informed consent? (3) What is the
      evidence regarding acceptability and effectiveness of testing? (4) What should be
      the acceptable standard of practice for conduct of invasive and noninvasive
      tests? (5) What is the boundary delineating "testing" and "reporting" vis-a-vis
      counseling? (6) What is the value of testing without counseling? (7) What
      assurances need to be in place to ensure voluntariness of testing? (8) How would 
      data from testing be used in "research," especially with the growth of practice
      based research networks? and (9) Does the American Dental Association Code of
      Ethics need to incorporate guidance for practicing dentists? We discuss how
      ethical principles can be used to develop a framework of guidelines for potential
      testing for systemic diseases in dental clinics..
FAU - Silveira, Marushka Leanne
AU  - Silveira ML
AD  - Division of Biostatistics & Epidemiology, University of Massachusetts, Amherst,
      MA.
FAU - Chattopadhyay, Amit
AU  - Chattopadhyay A
AD  - Office of Science Policy and Analysis National Institute of Dental and
      Craniofacial Research, National Institutes of Health, Bethesda, MD.
LA  - eng
GR  - Z99 DE999999/Intramural NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Ethics Biol Eng Med
JT  - Ethics in biology, engineering & medicine
JID - 101527948
PMC - PMC3940436
MID - NIHMS400743
OTO - NOTNLM
OT  - dental clinic
OT  - ethics
OT  - systemic disease
OT  - testing
EDAT- 2011/04/01 00:00
MHDA- 2011/04/01 00:01
CRDT- 2014/03/07 06:00
PHST- 2014/03/07 06:00 [entrez]
PHST- 2011/04/01 00:00 [pubmed]
PHST- 2011/04/01 00:01 [medline]
AID - 10.1615/EthicsBiologyEngMed.2012004545 [doi]
PST - ppublish
SO  - Ethics Biol Eng Med. 2011 Apr 1;2(2):115-136. doi:
      10.1615/EthicsBiologyEngMed.2012004545.


PMID- 23908807
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130805
LR  - 20220716
IS  - 2076-9172 (Print)
IS  - 2076-9172 (Linking)
VI  - 2
IP  - 2
DP  - 2011 Apr
TI  - Challenges in organ transplantation.
PG  - e0049
LID - 10.5041/RMMJ.10049 [doi]
AB  - Organ transplantation has progressed tremendously with improvements in surgical
      methods, organ preservation, and pharmaco-immunologic therapies and has become a 
      critical pathway in the management of severe organ failure worldwide. The major
      sources of organs are deceased donors after brain death; however, a substantial
      number of organs come from live donations, and a significant number can also be
      obtained from non-heart-beating donors. Yet, despite progress in medical,
      pharmacologic, and surgical techniques, the shortage of organs is a worldwide
      problem that needs to be addressed internationally at the highest possible
      levels. This particular field involves medical ethics, religion, and society
      behavior and beliefs. Some of the critical ethical issues that require aggressive
      interference are organ trafficking, payments for organs, and the delicate balance
      in live donations between the benefit to the recipient and the possible harm to
      the donor and others. A major issue in organ transplantation is the definition of
      death and particularly brain death. Another major critical factor is the internal
      tendency of a specific society to donate organs. In the review below, we will
      discuss the various challenges that face organ donation worldwide, and
      particularly in Israel, and some proposed mechanisms to overcome this difficulty.
FAU - Beyar, Rafael
AU  - Beyar R
AD  - Director, Rambam Health Care Campus, Haifa, Israel; Professor of Medicine &
      Biomedical Engineering, Women's Division - Dr Phillip & Sarah Gotlieb Chair,
      Technion, Haifa, Israel; Chairman of the Steering Committee of the Israel
      National Transplantation center, Ministry of Health, Tel Aviv, Israel.
LA  - eng
PT  - Journal Article
DEP - 20110430
PL  - Israel
TA  - Rambam Maimonides Med J
JT  - Rambam Maimonides medical journal
JID - 101538065
PMC - PMC3678939
OTO - NOTNLM
OT  - Israel National Transplantation Committee
OT  - brain and respiratory death
OT  - organ transplantation
EDAT- 2011/04/01 00:00
MHDA- 2011/04/01 00:01
CRDT- 2013/08/03 06:00
PHST- 2013/08/03 06:00 [entrez]
PHST- 2011/04/01 00:00 [pubmed]
PHST- 2011/04/01 00:01 [medline]
AID - 10.5041/RMMJ.10049 [doi]
AID - rmmj_2-2-e0049 [pii]
PST - epublish
SO  - Rambam Maimonides Med J. 2011 Apr 30;2(2):e0049. doi: 10.5041/RMMJ.10049. Print
      2011 Apr.


PMID- 23908804
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130805
LR  - 20211021
IS  - 2076-9172 (Print)
IS  - 2076-9172 (Linking)
VI  - 2
IP  - 2
DP  - 2011 Apr
TI  - Islamic sunni mainstream opinions on compensation to unrelated live organ donors.
PG  - e0046
LID - 10.5041/RMMJ.10046 [doi]
AB  - This article focuses on contemporary Islamic attitudes towards the question of
      compensation to a non-relative live organ donor. This article presents the
      history of the debate on organ transplantation in Islam since the 1950s and the
      key ethical questions. It continues by presenting the opinions of the mainstream 
      ulema such as Tantawi and Qaradawi. The article ends with a conclusion that there
      must be no compensation made to a non-related live organ donor, not even a
      symbolic gift of honor (ikramiyya).
FAU - Natour, Ahmad
AU  - Natour A
AD  - President, High Muslim Court of Appeal, Jerusalem, Israel, and.
FAU - Fishman, Shammai
AU  - Fishman S
LA  - eng
PT  - Journal Article
DEP - 20110430
PL  - Israel
TA  - Rambam Maimonides Med J
JT  - Rambam Maimonides medical journal
JID - 101538065
PMC - PMC3678941
OTO - NOTNLM
OT  - Islam
OT  - fatwa
OT  - organ donation
OT  - transplantation
EDAT- 2011/04/01 00:00
MHDA- 2011/04/01 00:01
CRDT- 2013/08/03 06:00
PHST- 2013/08/03 06:00 [entrez]
PHST- 2011/04/01 00:00 [pubmed]
PHST- 2011/04/01 00:01 [medline]
AID - 10.5041/RMMJ.10046 [doi]
AID - rmmj_2-2-e0046 [pii]
PST - epublish
SO  - Rambam Maimonides Med J. 2011 Apr 30;2(2):e0046. doi: 10.5041/RMMJ.10046. Print
      2011 Apr.


PMID- 23169083
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130110
LR  - 20220409
IS  - 1948-8270 (Electronic)
IS  - 1948-8270 (Linking)
VI  - 18
IP  - 2
DP  - 2011 Apr
TI  - Randomized comparison of 2 different methods of intrabronchial lidocaine delivery
      during flexible bronchoscopy: a pilot study.
PG  - 144-8
LID - 10.1097/LBR.0b013e318216da26 [doi]
AB  - BACKGROUND: Adequate anesthesia during bronchoscopy is essential for patient
      comfort and tolerance, and for achieving a good sample yield. The Enk device was 
      designed for use during anesthesia for awake intubations. The objective of this
      study was to compare patient tolerability and frequency of cough during flexible 
      bronchoscopy according to the method of administration of local anesthetic.
      METHODS: Patients were randomized to receive topical lidocaine either nebulized
      through an Enk device or with conventional injection through the working channel 
      of the bronchoscope. All patients, physicians, and the assisting nurse completed 
      a questionnaire that included items on tolerability, ease of procedure, frequency
      of cough, etc. The response was marked on a 10-cm-long visual analog scale, with 
      a higher score indicating better outcome. RESULTS: Fifty patients were divided
      into 2 groups of 25 patients each. The mean +/- standard deviation duration of
      procedure was no different in the Enk group than in the syringe group (12.8 +/-
      7.5 and 10.8 +/- 6.9 min, respectively). There was no statistically significant
      difference between the 2 groups in the scores of each of the questions.
      CONCLUSIONS: The Enk device showed a nonsignificant trend toward greater ease of 
      procedure for the operator with no difference in the frequency of cough. For the 
      patients, there was no significant difference. A further investigation through
      comparison with other methods, such as transtracheal installation, over a larger 
      population may yield more significant results. TRIAL REGISTRATION: This trial was
      registered with the Local Research Ethics Committee and with International
      Standard Randomised Controlled Trial Number.
FAU - MacDougall, Michelle
AU  - MacDougall M
AD  - Department of Respiratory Medicine, Salford Royal Foundation Trust, Salford, UK. 
      michelle.macdougall@srft.nhs.uk
FAU - Mohan, Anant
AU  - Mohan A
FAU - Mills, Janet
AU  - Mills J
FAU - Munavvar, Mohammed
AU  - Munavvar M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Bronchology Interv Pulmonol
JT  - Journal of bronchology & interventional pulmonology
JID - 101496866
EDAT- 2011/04/01 00:00
MHDA- 2011/04/01 00:01
CRDT- 2012/11/22 06:00
PHST- 2012/11/22 06:00 [entrez]
PHST- 2011/04/01 00:00 [pubmed]
PHST- 2011/04/01 00:01 [medline]
AID - 10.1097/LBR.0b013e318216da26 [doi]
AID - 01436970-201104000-00008 [pii]
PST - ppublish
SO  - J Bronchology Interv Pulmonol. 2011 Apr;18(2):144-8. doi:
      10.1097/LBR.0b013e318216da26.


PMID- 22929723
OWN - NLM
STAT- MEDLINE
DCOM- 20130118
LR  - 20191210
IS  - 1999-6217 (Electronic)
IS  - 1727-5482 (Linking)
VI  - 9
IP  - 1
DP  - 2011 Apr
TI  - Health impacts and research ethics in female trafficking.
PG  - 89-91
AB  - Female trafficking is a social and public health problem, associated with
      physical and sexual abuse, psychological trauma, injuries from violence, sexually
      transmitted infections, adverse reproductive outcomes and substance misuse. It
      faces several challenges ranging from the hidden nature of the problem to ethical
      and human rights issues. The objectives of this paper are to analyze health
      impact of trafficking; ethical and research issues and anti-trafficking
      strategies in the Nepalese context. We collected published and unpublished data
      assessing the public health, ethical burden and research needs from different
      sources. Trafficked female involved in sex-industry that face grave situation as 
      depicted and it might a reservoir of sexually transmitted diseases. Ethical
      issues related to survey of assessing the burden are difficult to carry out. The 
      best ways to prevent and control these problems are to enhance anti- trafficking 
      laws and raise awareness, empower and mobilize females and establish
      organizational capacity.
FAU - Dhital, S R
AU  - Dhital SR
AD  - Unit for Health Promotion Research, University of Southern Denmark, Esbjerg,
      Denmark. heducator@gmail.com
FAU - Aro, R A
AU  - Aro RA
FAU - Sapkota, K
AU  - Sapkota K
LA  - eng
PT  - Journal Article
PL  - Nepal
TA  - J Nepal Health Res Counc
JT  - Journal of Nepal Health Research Council
JID - 101292936
SB  - IM
MH  - *Crime
MH  - *Ethics, Research
MH  - Female
MH  - *Health Status
MH  - Humans
MH  - Nepal
MH  - Power, Psychological
MH  - *Sex Work
EDAT- 2011/04/01 00:00
MHDA- 2013/01/19 06:00
CRDT- 2012/08/30 06:00
PHST- 2012/08/30 06:00 [entrez]
PHST- 2011/04/01 00:00 [pubmed]
PHST- 2013/01/19 06:00 [medline]
PST - ppublish
SO  - J Nepal Health Res Counc. 2011 Apr;9(1):89-91.


PMID- 22929722
OWN - NLM
STAT- MEDLINE
DCOM- 20130118
LR  - 20120829
IS  - 1999-6217 (Electronic)
IS  - 1727-5482 (Linking)
VI  - 9
IP  - 1
DP  - 2011 Apr
TI  - Scenario of health camps in Nepal.
PG  - 86-8
AB  - It has become a rising trend in Nepal to conduct health camps. This article tries
      to give an overview about the direction to which this aspect of community based
      service is going to and also points out a few pros and cons related to this. A
      couple of issues has also been raised like; ethical issues, lack of governing
      bodies and a lack of national policy, unavailability of data upon health camps
      and so forth. Above all, this article tries to clarify the importance of
      conducting health camps in a country like ours and if properly conducted this has
      a balanced benefit to all.
FAU - Pandey, A
AU  - Pandey A
AD  - Department of Cardiology, Shahid Gangalal National Heart Centre, Bansbari,
      Kathmandu, Nepal. aranikopandey@gmail.com
FAU - Paudel, P
AU  - Paudel P
FAU - Paudel, L
AU  - Paudel L
LA  - eng
PT  - Journal Article
PL  - Nepal
TA  - J Nepal Health Res Counc
JT  - Journal of Nepal Health Research Council
JID - 101292936
SB  - IM
MH  - Community Health Services/*organization & administration
MH  - Community-Institutional Relations
MH  - Nepal
MH  - *Referral and Consultation
EDAT- 2011/04/01 00:00
MHDA- 2013/01/19 06:00
CRDT- 2012/08/30 06:00
PHST- 2012/08/30 06:00 [entrez]
PHST- 2011/04/01 00:00 [pubmed]
PHST- 2013/01/19 06:00 [medline]
PST - ppublish
SO  - J Nepal Health Res Counc. 2011 Apr;9(1):86-8.


PMID- 22701397
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1583-5170 (Print)
IS  - 1583-5170 (Linking)
VI  - 9
IP  - 2
DP  - 2011 Apr
TI  - ETHICAL REVIEW OF BIOMEDICAL RESEARCH IN BELARUS: CURRENT STATUS, PROBLEMS AND
      PERSPECTIVES.
PG  - 74-83
AB  - The paper provides description of the system of ethical review for biomedical
      research in Belarus, with special emphasis on its historical background, legal
      and regulatory framework, structure and functioning. It concludes that the
      situation with research ethics in Belarus corresponds to the tendency of
      bureaucratic approach to establishment of systems of ethical review for
      biomedical research, observed in a number of countries of Central and Eastern
      Europe. Different social, economical and political factors of transition have
      major impact on capacities of the Belarusian RECs to ensure adequate protection
      of human subjects. Among the main problems identified are non-equivalent
      stringency of ethical review for different types of biomedical research; lack of 
      independence, multidisciplinarity, pluralism and lay representation experienced
      by RECs; low level of research ethics education and transparency of RECs
      activities. Recommendations are made to raise the issue of research ethics on the
      national agenda in order to develop and maintain the research ethics system
      capable to effectively protect research participants and promote ethical conduct 
      in research.
FAU - Famenka, Andrei
AU  - Famenka A
AD  - Legal medicine specialist, the State Service of Legal Medicine, Minsk, Belarus,
      fomenko_expert@mail.ru.
LA  - eng
GR  - R25 TW007085/TW/FIC NIH HHS/United States
GR  - R25 TW007085-08/TW/FIC NIH HHS/United States
PT  - Journal Article
PL  - Romania
TA  - Rev Rom Bioet
JT  - Revista romana de bioetica
JID - 101205285
PMC - PMC3372927
MID - NIHMS367381
EDAT- 2011/04/01 00:00
MHDA- 2011/04/01 00:01
CRDT- 2012/06/16 06:00
PHST- 2012/06/16 06:00 [entrez]
PHST- 2011/04/01 00:00 [pubmed]
PHST- 2011/04/01 00:01 [medline]
PST - ppublish
SO  - Rev Rom Bioet. 2011 Apr;9(2):74-83.


PMID- 21448589
OWN - NLM
STAT- MEDLINE
DCOM- 20111230
LR  - 20211020
IS  - 0219-1032 (Electronic)
IS  - 1016-8478 (Linking)
VI  - 32
IP  - 2
DP  - 2011 Aug
TI  - Pluripotency of male germline stem cells.
PG  - 113-21
LID - 10.1007/s10059-011-1024-4 [doi]
AB  - The ethical issues and public concerns regarding the use of embryonic stem (ES)
      cells in human therapy have motivated considerable research into the generation
      of pluripotent stem cell lines from non-embryonic sources. Numerous reports have 
      shown that pluripotent cells can be generated and derived from germline stem
      cells (GSCs) in mouse and human testes during in vitro cultivation. The gene
      expression patterns of these cells are similar to those of ES cells and show the 
      typical self-renewal and differentiation patterns of pluripotent cells in vivo
      and in vitro. However, the mechanisms underlying the spontaneous
      dedifferentiation of GSCs remain to be elucidated. Studies to identify master
      regulators in this reprogramming process are of critical importance for
      understanding the gene regulatory networks that sustain the cellular status of
      these cells. The results of such studies would provide a theoretical background
      for the practical use of these cells in regenerative medicine. Such studies would
      also help elucidate the molecular mechanisms underlying certain diseases, such as
      testicular germ cell tumors.
FAU - Kim, Sungtae
AU  - Kim S
AD  - Department of Chemistry, Korea University, Seoul 136-701, Korea.
FAU - Izpisua Belmonte, Juan Carlos
AU  - Izpisua Belmonte JC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110324
PL  - Korea (South)
TA  - Mol Cells
JT  - Molecules and cells
JID - 9610936
SB  - IM
MH  - Animals
MH  - Cell Dedifferentiation/genetics
MH  - Gene Expression Profiling
MH  - Gene Regulatory Networks
MH  - Germ Cells/*physiology
MH  - Humans
MH  - Male
MH  - Mice
MH  - Pluripotent Stem Cells/*physiology/transplantation
MH  - Regenerative Medicine
MH  - *Stem Cell Transplantation
MH  - Testicular Neoplasms/pathology/*therapy
PMC - PMC3887674
EDAT- 2011/03/31 06:00
MHDA- 2011/12/31 06:00
CRDT- 2011/03/31 06:00
PHST- 2011/02/10 00:00 [received]
PHST- 2011/03/07 00:00 [accepted]
PHST- 2011/03/06 00:00 [revised]
PHST- 2011/03/31 06:00 [entrez]
PHST- 2011/03/31 06:00 [pubmed]
PHST- 2011/12/31 06:00 [medline]
AID - 10.1007/s10059-011-1024-4 [doi]
PST - ppublish
SO  - Mol Cells. 2011 Aug;32(2):113-21. doi: 10.1007/s10059-011-1024-4. Epub 2011 Mar
      24.


PMID- 21448547
OWN - NLM
STAT- MEDLINE
DCOM- 20110809
LR  - 20211203
IS  - 1972-6007 (Electronic)
IS  - 0009-9074 (Linking)
VI  - 162
IP  - 1
DP  - 2011
TI  - From bench to bedside and to health policies: ethics in translational research.
PG  - 51-9
AB  - Translation of biomedical research knowledge to effective clinical treatment is
      essential to the public good. The first level of translation ("from bench to
      bedside") corresponds to efficacy studies under controlled conditions with
      careful attention to internal validity (clinical research). The second level is
      the translation of results from clinical studies into everyday clinical practice 
      and health decision making. The article summarises the ethical issues involved in
      the translation of biomedical research advances to clinical applications and to
      clinical practice. In particular, the article synthesizes theory from clinical
      ethics, operational design, and philosophy to examine the unique bioethical
      issues raised by the recent focus on translational research. In this framework
      safety of study participants and balancing of risk due to treatment with the
      potential benefits of the research are crucial: in clinical research there is a
      danger that the emphasis on advancements in scientific knowledge might prevail
      over the protection of the people who participate in research. These issues
      involve basic scientists, clinicians and bioethicists because of their
      application to comparative effectiveness research, clinical trials and
      evidence-based medicine, as well basic biomedical research.
FAU - Petrini, C
AU  - Petrini C
AD  - Bioethics Unit, Office of the President, Istituto Superiore di Sanita, Rome,
      Italy. carlo.petrini@iss.it
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - Clin Ter
JT  - La Clinica terapeutica
JID - 0372604
SB  - IM
MH  - Adult
MH  - Animal Experimentation
MH  - Animals
MH  - Bioethics
MH  - Clinical Trials as Topic/ethics
MH  - Control Groups
MH  - *Health Policy
MH  - Human Experimentation/ethics
MH  - Humans
MH  - Informed Consent
MH  - Moral Obligations
MH  - Patients/psychology
MH  - Risk Assessment
MH  - Role
MH  - Therapeutic Human Experimentation/ethics/legislation & jurisprudence
MH  - Translational Research, Biomedical/*ethics
MH  - Young Adult
EDAT- 2011/03/31 06:00
MHDA- 2011/08/10 06:00
CRDT- 2011/03/31 06:00
PHST- 2011/03/31 06:00 [entrez]
PHST- 2011/03/31 06:00 [pubmed]
PHST- 2011/08/10 06:00 [medline]
PST - ppublish
SO  - Clin Ter. 2011;162(1):51-9.


PMID- 21447857
OWN - NLM
STAT- MEDLINE
DCOM- 20110725
LR  - 20190513
IS  - 1930-6180 (Electronic)
IS  - 1084-2020 (Linking)
VI  - 52
IP  - 1
DP  - 2011
TI  - The Brazilian legal framework on the scientific use of animals.
PG  - E8-15
AB  - Brazil has an exceptionally dynamic research sector in Latin America in health,
      biotechnology, and pharmacology, backed by defined government policies on science
      and technology and a health research agenda focusing on important neglected
      diseases: malaria, leishmaniasis, Chagas disease, turberculosis, leprosy, and
      dengue. The Brazilian health research policy promotes partnerships and networks
      among scientists in academic institutions in both wealthy industrialized and
      disease-endemic countries, and in these efforts the government's guidelines for
      animal use in biomedical research are considered fundamental to guarantee both
      animal welfare and the quality of research. Given international discussions of
      animal experimentation regulations and guidelines, in this article we describe
      current Brazilian legislation governing the use of animals in scientific
      investigations. We conclude that, despite advances in the implementation of the
      3Rs (reduction, refinement, replacement), the new regulatory framework does not
      sufficiently incorporate ethical considerations, lacking explicit reference to
      the 3Rs as well as measures for their full application. The more humane use of
      animals in research will depend on the approach adopted by Brazil's National
      Council for the Control of Animal Experimentation to promote the 3Rs and to
      improve internal regulations as well as data collection and analysis in research 
      institutions. In Brazil as elsewhere, one of the greatest challenges to
      policymakers is to harmonize the myriad and intertwined legal provisions without 
      hindering biomedical research.
FAU - Filipecki, Ana Tereza Pinto
AU  - Filipecki AT
AD  - Escola Politecnica de Saude Joaquim Venancio (EPSJV/LIC-Provoc), Fundacao Oswaldo
      Cruz (Fiocruz), Av. Brasil, 4365, Manguinhos, Rio de Janeiro CEP 21040-360,
      Brazil. afilipecki@fiocruz.br
FAU - Machado, Carlos Jose Saldanha
AU  - Machado CJ
FAU - Valle, Silvio
AU  - Valle S
FAU - Teixeira, Marcia de Oliveira
AU  - Teixeira Mde O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - ILAR J
JT  - ILAR journal
JID - 9516416
SB  - IM
MH  - Animal Experimentation/*legislation & jurisprudence
MH  - Animal Rights/legislation & jurisprudence
MH  - Animal Welfare/legislation & jurisprudence
MH  - Animals
MH  - Biomedical Research/*legislation & jurisprudence
MH  - Brazil
EDAT- 2011/03/31 06:00
MHDA- 2011/07/26 06:00
CRDT- 2011/03/31 06:00
PHST- 2011/03/31 06:00 [entrez]
PHST- 2011/03/31 06:00 [pubmed]
PHST- 2011/07/26 06:00 [medline]
AID - 10.1093/ilar.52.1.e8 [doi]
PST - ppublish
SO  - ILAR J. 2011;52(1):E8-15. doi: 10.1093/ilar.52.1.e8.


PMID- 21447578
OWN - NLM
STAT- MEDLINE
DCOM- 20110525
LR  - 20181023
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 342
DP  - 2011 Mar 29
TI  - Unethical health reforms. This ethical argument seems irrelevant to the real
      world.
PG  - d1946
LID - 10.1136/bmj.d1946 [doi]
LID - bmj.d1946 [pii]
FAU - Black, Stephen
AU  - Black S
LA  - eng
PT  - Letter
PT  - Comment
DEP - 20110329
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
SB  - IM
CON - BMJ. 2011;342:d1430. PMID: 21393319
MH  - Family Practice/*ethics
MH  - Gatekeeping/*ethics
MH  - Humans
MH  - State Medicine/*ethics
MH  - United Kingdom
EDAT- 2011/03/31 06:00
MHDA- 2011/05/26 06:00
CRDT- 2011/03/31 06:00
PHST- 2011/03/31 06:00 [entrez]
PHST- 2011/03/31 06:00 [pubmed]
PHST- 2011/05/26 06:00 [medline]
AID - 10.1136/bmj.d1946 [doi]
PST - epublish
SO  - BMJ. 2011 Mar 29;342:d1946. doi: 10.1136/bmj.d1946.


PMID- 21447161
OWN - NLM
STAT- MEDLINE
DCOM- 20110802
LR  - 20211020
IS  - 1471-227X (Electronic)
IS  - 1471-227X (Linking)
VI  - 11
DP  - 2011 Mar 29
TI  - Prehospital evaluation and economic analysis of different coronary syndrome
      treatment strategies--PREDICT--rationale, development and implementation.
PG  - 4
LID - 10.1186/1471-227X-11-4 [doi]
AB  - BACKGROUND: A standard of prehospital care for patients presenting with
      ST-segment elevation myocardial infarction (STEMI) includes prehospital 12-lead
      and advance Emergency Department notification or prehospital bypass to
      percutaneous coronary intervention centres. Implementation of either care
      strategies is variable across communities and neither may exist in some
      communities. The main objective is to compare prehospital care strategies for
      time to treatment and survival outcomes as well as cost effectiveness.
      METHODS/DESIGN: PREDICT is a multicentre, prospective population-based cohort
      study of all chest pain patients 18 years or older presenting within 30 mins to 6
      hours of symptom onset and treated with nitroglycerin, transported by paramedics 
      in a number of different urban and rural regions in Ontario. The primary
      objective of this study is to compare the proportion of study subjects who
      receive reperfusion within the target door-to-reperfusion times in subjects
      obtained after four prehospital strategies: 12-lead ECG and advance emergency
      department (ED) notification or 3-lead ECG monitoring and alert to dispatch prior
      to hospital arrival; either with or without the opportunity to bypass to a PCI
      centre. DISCUSSION: We anticipate four challenges to successful study
      implementation and have developed strategies for each: 1) diversity in the
      interpretation of the ethical and privacy issues across 47 research ethics
      boards/committees covering 71 hospitals, 2) remote oversight of data guardian
      abstraction, 3) timeliness of implementation, and 4) potential interference in
      the study by concurrent technological advances. Research ethics approvals from
      academic centres were obtained initially and submitted to non academic centre
      applications. Data guardians were trained by a single investigator and data entry
      is informed by a detailed data dictionary including variable definitions and
      abstraction instructions and subjected to error and logic checks. Quality
      oversight provided by a single investigator. The window of the trial in each
      community has been confirmed with the base-hospital medical director to
      correspond to the planned technological advances of the system of care. We hope
      this comparative analysis across treatment strategies for clinical outcomes and
      cost will provide sufficient evidence to implement the superior strategy across
      all communities and improve outcomes for all STEMI patients.
FAU - Morrison, Laurie J
AU  - Morrison LJ
AD  - Rescue, Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's
      Hospital, University of Toronto, Toronto, Ontario, Canada. MorrisonL@smh.ca
FAU - Rac, Valeria E
AU  - Rac VE
FAU - Bowen, James M
AU  - Bowen JM
FAU - Schwartz, Brian
AU  - Schwartz B
FAU - Perreira, Tyrone
AU  - Perreira T
FAU - Ryan, Welson
AU  - Ryan W
FAU - Zahn, Cathy
AU  - Zahn C
FAU - Chadha, Rishab
AU  - Chadha R
FAU - Craig, Alan
AU  - Craig A
FAU - O'Reilly, Daria
AU  - O'Reilly D
FAU - Goeree, Ron
AU  - Goeree R
LA  - eng
SI  - ClinicalTrials.gov/NCT00747656
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20110329
PL  - England
TA  - BMC Emerg Med
JT  - BMC emergency medicine
JID - 100968543
RN  - G59M7S0WS3 (Nitroglycerin)
SB  - IM
MH  - Acute Coronary Syndrome/*therapy
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Clinical Protocols
MH  - Cohort Studies
MH  - Cost-Benefit Analysis
MH  - Electrocardiography/*economics/methods
MH  - Emergency Medical Services/*economics/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/diagnosis/therapy
MH  - *Myocardial Reperfusion/economics
MH  - Nitroglycerin/therapeutic use
MH  - Ontario
MH  - Prospective Studies
MH  - Time Factors
MH  - Transportation of Patients
MH  - Young Adult
PMC - PMC3076236
EDAT- 2011/03/31 06:00
MHDA- 2011/08/04 06:00
CRDT- 2011/03/31 06:00
PHST- 2010/11/27 00:00 [received]
PHST- 2011/03/29 00:00 [accepted]
PHST- 2011/03/31 06:00 [entrez]
PHST- 2011/03/31 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
AID - 1471-227X-11-4 [pii]
AID - 10.1186/1471-227X-11-4 [doi]
PST - epublish
SO  - BMC Emerg Med. 2011 Mar 29;11:4. doi: 10.1186/1471-227X-11-4.


PMID- 21446781
OWN - NLM
STAT- MEDLINE
DCOM- 20120117
LR  - 20211020
IS  - 1557-7422 (Electronic)
IS  - 1043-0342 (Linking)
VI  - 22
IP  - 9
DP  - 2011 Sep
TI  - When ethics constrains clinical research: trial design of control arms in
      "greater than minimal risk" pediatric trials.
PG  - 1121-7
LID - 10.1089/hum.2010.230 [doi]
AB  - For more than three decades clinical research in the United States has been
      explicitly guided by the idea that ethical considerations must be central to
      research design and practice. In spite of the centrality of this idea, attempting
      to balance the sometimes conflicting values of advancing scientific knowledge and
      protecting human subjects continues to pose challenges. Possible conflicts
      between the standards of scientific research and those of ethics are particularly
      salient in relation to trial design. Specifically, the choice of a control arm is
      an aspect of trial design in which ethical and scientific issues are deeply
      entwined. Although ethical quandaries related to the choice of control arms may
      arise when conducting any type of clinical trials, they are conspicuous in early 
      phase gene transfer trials that involve highly novel approaches and surgical
      procedures and have children as the research subjects. Because of children's and 
      their parents' vulnerabilities, in trials that investigate therapies for fatal,
      rare diseases affecting minors, the scientific and ethical concerns related to
      choosing appropriate controls are particularly significant. In this paper we use 
      direct gene transfer to the central nervous system to treat late infantile
      neuronal ceroid lipofuscinosis to illustrate some of these ethical issues and
      explore possible solutions to real and apparent conflicts between scientific and 
      ethical considerations.
FAU - de Melo-Martin, Inmaculada
AU  - de Melo-Martin I
AD  - Division of Medical Ethics, Department of Public Health, Weill Cornell Medical
      College, New York, NY 10065, USA.
FAU - Sondhi, Dolan
AU  - Sondhi D
FAU - Crystal, Ronald G
AU  - Crystal RG
LA  - eng
GR  - R01 NS061848/NS/NINDS NIH HHS/United States
GR  - U01 NS047458/NS/NINDS NIH HHS/United States
GR  - UL1-RR024996/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110519
PL  - United States
TA  - Hum Gene Ther
JT  - Human gene therapy
JID - 9008950
RN  - Ceroid lipofuscinosis, neuronal 1, infantile
SB  - IM
MH  - Animals
MH  - Biomedical Research/ethics
MH  - Central Nervous System/metabolism
MH  - Child
MH  - Controlled Clinical Trials as Topic/*ethics
MH  - Genetic Therapy/*ethics
MH  - Humans
MH  - Neuronal Ceroid-Lipofuscinoses/genetics/therapy
MH  - Pediatrics/ethics
MH  - Research Design
MH  - *Research Subjects
MH  - Transduction, Genetic
PMC - PMC3177948
EDAT- 2011/03/31 06:00
MHDA- 2012/01/18 06:00
CRDT- 2011/03/31 06:00
PHST- 2011/03/31 06:00 [entrez]
PHST- 2011/03/31 06:00 [pubmed]
PHST- 2012/01/18 06:00 [medline]
AID - 10.1089/hum.2010.230 [doi]
PST - ppublish
SO  - Hum Gene Ther. 2011 Sep;22(9):1121-7. doi: 10.1089/hum.2010.230. Epub 2011 May
      19.


PMID- 21445913
OWN - NLM
STAT- MEDLINE
DCOM- 20110725
LR  - 20110329
IS  - 1539-3429 (Electronic)
IS  - 1470-8175 (Linking)
VI  - 39
IP  - 2
DP  - 2011 Mar-Apr
TI  - Hypothetical biotechnology companies: A role-playing student centered activity
      for undergraduate science students.
PG  - 173-9
LID - 10.1002/bmb.20480 [doi]
AB  - Science students leaving undergraduate programs are entering the biotechnology
      industry where they are presented with issues which require integration of
      science content. Students find this difficult as through-out their studies, most 
      content is limited to a single subdiscipline (e.g., biochemistry, immunology). In
      addition, students need knowledge of the ethical, economic, and legal frame work 
      in which the industry operates. This article presents an approach to deliver
      these outcomes in a collaborative and active learning modality which promotes
      deep learning. In the model, groups of final year undergraduate students form
      hypothetical biotechnology companies and identify real issues of interest to
      industry, make integrative team decisions, use professional level technology, and
      develop appropriate communication skills. The final successful teaching paradigm 
      was based on self reflection, observation, and student feedback to ensure
      appropriate attainment of content, group work skills and increased confidence in 
      professional decision-making. It is these outcomes which will facilitate life
      long learning skills, a major outcome applicable for all tertiary education.
CI  - Copyright (c) 2011 Wiley Periodicals, Inc.
FAU - Chuck, Jo-Anne
AU  - Chuck JA
AD  - School of Natural Sciences (Parramatta Campus), University of Western Sydney,
      Penrith South DC 1797, New South Wales, Australia. j.chuck@uws.edu.au
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Biochem Mol Biol Educ
JT  - Biochemistry and molecular biology education : a bimonthly publication of the
      International Union of Biochemistry and Molecular Biology
JID - 100970605
SB  - IM
MH  - Biotechnology/*education
MH  - Curriculum
MH  - Decision Making
MH  - Humans
MH  - Problem-Based Learning/methods
MH  - *Role Playing
MH  - Students/*psychology
MH  - Teaching/*methods
EDAT- 2011/03/30 06:00
MHDA- 2011/07/26 06:00
CRDT- 2011/03/30 06:00
PHST- 2011/03/30 06:00 [entrez]
PHST- 2011/03/30 06:00 [pubmed]
PHST- 2011/07/26 06:00 [medline]
AID - 10.1002/bmb.20480 [doi]
PST - ppublish
SO  - Biochem Mol Biol Educ. 2011 Mar-Apr;39(2):173-9. doi: 10.1002/bmb.20480.


PMID- 21445862
OWN - NLM
STAT- MEDLINE
DCOM- 20111102
LR  - 20131121
IS  - 1097-4644 (Electronic)
IS  - 0730-2312 (Linking)
VI  - 112
IP  - 8
DP  - 2011 Aug
TI  - Synthetic sulfonyl-hydrazone-1 positively regulates cardiomyogenic microRNA
      expression and cardiomyocyte differentiation of induced pluripotent stem cells.
PG  - 2006-14
LID - 10.1002/jcb.23118 [doi]
AB  - Induced pluripotent stem cells (iPSCs) are obtained from adult cells through
      overexpression of pluripotency factors. iPSCs share many features with embryonic 
      stem cells (ESCs), circumventing ethical issues, and, noteworthy, match donor's
      genotype. iPSCs represent therefore a valuable tool for regenerative medicine.
      Cardiac differentiation of ESCs can be enhanced via microRNAs (miRNAs) and small 
      chemical compounds, which probably act as chromatin remodelers. Cardiomyogenic
      potential of iPSCs is currently intensely investigated for cell therapy or in
      vitro drug screening and disease modeling. However, influences of small compounds
      on iPSC-related cardiomyogenesis have not yet been investigated in details. Here,
      we compared the effects of two small molecules, bis-peroxo-vanadium (bpV) and
      sulfonyl-hydrazone-1 (SHZ) at varying concentrations, during cardiac
      differentiation of murine iPSCs. SHZ (5 microM) enhanced specific marker
      expression and cardiomyocyte yield, without loss of cell viability. In contrast, 
      bpV showed negligible effects on cardiac differentiation rate and appeared to
      induce Casp3-dependent apoptosis in differentiating iPSCs. Furthermore,
      SHZ-treated iPSCs were able to increase beating foci rate and upregulate early
      and late cardiomyogenic miRNA expression (miR-1, miR-133a, and miR-208a). Thus,
      our results demonstrate that small chemical compounds, such as SHZ, can
      constitute a novel and clinically feasible strategy to improve iPSC-derived
      cardiac differentiation.
CI  - Copyright (c) 2011 Wiley-Liss, Inc.
FAU - Quattrocelli, Mattia
AU  - Quattrocelli M
AD  - Translational Cardiomyology, Stem Cell Institute, K.U.Leuven, Leuven, Belgium.
FAU - Palazzolo, Giacomo
AU  - Palazzolo G
FAU - Agnolin, Irene
AU  - Agnolin I
FAU - Martino, Sabata
AU  - Martino S
FAU - Bouche, Marina
AU  - Bouche M
FAU - Anastasia, Luigi
AU  - Anastasia L
FAU - Sampaolesi, Maurilio
AU  - Sampaolesi M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Cell Biochem
JT  - Journal of cellular biochemistry
JID - 8205768
RN  - 0 (Antigens, Differentiation)
RN  - 0 (Hydrazones)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (MicroRNAs)
RN  - 0 (Sulfones)
RN  - 0 (peroxovanadate)
RN  - 3WHH0066W5 (Vanadates)
RN  - EC 3.4.22.- (Casp3 protein, mouse)
RN  - EC 3.4.22.- (Caspase 3)
SB  - IM
MH  - Animals
MH  - Antigens, Differentiation/biosynthesis
MH  - Caspase 3/metabolism
MH  - Cell Differentiation
MH  - Cell- and Tissue-Based Therapy/methods
MH  - Gene Expression Regulation/*drug effects/physiology
MH  - Hydrazones/chemical synthesis/*pharmacology
MH  - Hypoglycemic Agents/pharmacology
MH  - Induced Pluripotent Stem Cells/cytology/*metabolism
MH  - Mice
MH  - MicroRNAs/*biosynthesis
MH  - Myocytes, Cardiac/cytology/*metabolism
MH  - Sulfones/chemical synthesis/*pharmacology
MH  - Vanadates/pharmacology
EDAT- 2011/03/30 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/03/30 06:00
PHST- 2011/03/30 06:00 [entrez]
PHST- 2011/03/30 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
AID - 10.1002/jcb.23118 [doi]
PST - ppublish
SO  - J Cell Biochem. 2011 Aug;112(8):2006-14. doi: 10.1002/jcb.23118.


PMID- 21445480
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20191027
IS  - 1678-2674 (Electronic)
IS  - 0102-8650 (Linking)
VI  - 26
IP  - 2
DP  - 2011 Apr
TI  - Proposal of a synthetic ethylene-vinyl acetate bench model for surgical
      foundations learning: suture training.
PG  - 149-52
LID - S0102-86502011000200014 [pii]
AB  - Due to ethical and legal aspects involved in the handling of cadavers and animals
      the synthetic simulators are an alternative for learning how to suture technique 
      plus the practice of various procedures such as incision and surgical flap. In
      this context, this paper describes and propose the use of a synthetic model
      manufactured from plates of ethylene-vinyl acetate (EVA) to teach primary
      surgical skills in medical students with no previous exposure to surgery. The
      model that provides the convenience of being easily reproducible, allowing the
      students in training can thus improve their skills before applying the technique 
      in clinical practice.
FAU - Bastos, Erika Malheiros
AU  - Bastos EM
AD  - Department of Surgery, School of Medical Sciences, UNIMAR, Marilia, SP, Brazil.
      erika.mb@uol.com.br
FAU - Silva, Rafael Denadai Pigozzi
AU  - Silva RD
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - Acta Cir Bras
JT  - Acta cirurgica brasileira
JID - 9103983
RN  - 0 (Polyvinyls)
RN  - 24937-78-8 (ethylenevinylacetate copolymer)
SB  - IM
MH  - Clinical Competence
MH  - Education, Medical/*methods
MH  - General Surgery/*education
MH  - Humans
MH  - *Polyvinyls/economics
MH  - Students, Medical
MH  - Suture Techniques/economics/*education/ethics
EDAT- 2011/03/30 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/03/30 06:00
PHST- 2010/09/10 00:00 [received]
PHST- 2010/12/14 00:00 [accepted]
PHST- 2011/03/30 06:00 [entrez]
PHST- 2011/03/30 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - S0102-86502011000200014 [pii]
AID - 10.1590/s0102-86502011000200014 [doi]
PST - ppublish
SO  - Acta Cir Bras. 2011 Apr;26(2):149-52. doi: 10.1590/s0102-86502011000200014.


PMID- 21445467
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20191027
IS  - 1678-2674 (Electronic)
IS  - 0102-8650 (Linking)
VI  - 26
IP  - 2
DP  - 2011 Apr
TI  - [Moral and ethical importance of experimental research to clinical practice].
PG  - 80-1
LID - S0102-86502011000200001 [pii]
FAU - Goldenberg, Saul
AU  - Goldenberg S
LA  - por
PT  - Editorial
TT  - Importancia etica e moral da pesquisa experimental para a pratica medica.
PL  - Brazil
TA  - Acta Cir Bras
JT  - Acta cirurgica brasileira
JID - 9103983
SB  - IM
MH  - Animal Experimentation/*ethics/legislation & jurisprudence
MH  - Animals
MH  - Humans
EDAT- 2011/03/30 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/03/30 06:00
PHST- 2011/03/30 06:00 [entrez]
PHST- 2011/03/30 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - S0102-86502011000200001 [pii]
AID - 10.1590/s0102-86502011000200001 [doi]
PST - ppublish
SO  - Acta Cir Bras. 2011 Apr;26(2):80-1. doi: 10.1590/s0102-86502011000200001.


PMID- 21445091
OWN - NLM
STAT- MEDLINE
DCOM- 20110914
LR  - 20110523
IS  - 1473-1150 (Electronic)
IS  - 1470-269X (Linking)
VI  - 11
IP  - 3
DP  - 2011 Jun
TI  - Informed consent in the context of pharmacogenomic research: ethical
      considerations.
PG  - 155-61
LID - 10.1038/tpj.2011.11 [doi]
AB  - Although the scientific research surrounding pharmacogenomics (PGx) has been
      relatively plentiful, the ethical research concerning this discipline has
      developed rather conservatively. Following investigation of the ethical, legal
      and social issues (ELSI) of PGx research, as well as consulting with key
      stakeholders, we identified six outstanding ethical issues raised by the informed
      consent process in PGx research: (1) scope of consent; (2) consent to 'add-on'
      studies; (3) protection of personal information; (4) commercialization; (5) data 
      sharing; and (6) potential risks stemming from population-based research. In
      discussing these six areas as well as offering specific considerations, this
      article offers a solid base from which future practical guidelines for informed
      consent in PGx research can be constructed. As such, this effort works toward
      filling the ELSI gap and provides ethical support to the numerous PGx projects
      undertaken by researchers every year.
FAU - Howard, H C
AU  - Howard HC
AD  - Centre for Biomedical Ethics and Law, KULeuven, Leuven, Belgium.
      heidi.howard@med.kuleuven.be
FAU - Joly, Y
AU  - Joly Y
FAU - Avard, D
AU  - Avard D
FAU - Laplante, N
AU  - Laplante N
FAU - Phillips, M
AU  - Phillips M
FAU - Tardif, J C
AU  - Tardif JC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110329
PL  - United States
TA  - Pharmacogenomics J
JT  - The pharmacogenomics journal
JID - 101083949
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Confidentiality/ethics
MH  - Humans
MH  - Information Dissemination/ethics
MH  - Informed Consent/*ethics/legislation & jurisprudence
MH  - Pharmacogenetics/economics/*ethics/legislation & jurisprudence
EDAT- 2011/03/30 06:00
MHDA- 2011/09/15 06:00
CRDT- 2011/03/30 06:00
PHST- 2011/03/30 06:00 [entrez]
PHST- 2011/03/30 06:00 [pubmed]
PHST- 2011/09/15 06:00 [medline]
AID - tpj201111 [pii]
AID - 10.1038/tpj.2011.11 [doi]
PST - ppublish
SO  - Pharmacogenomics J. 2011 Jun;11(3):155-61. doi: 10.1038/tpj.2011.11. Epub 2011
      Mar 29.


PMID- 21445006
OWN - NLM
STAT- MEDLINE
DCOM- 20111220
LR  - 20190516
IS  - 1554-8619 (Electronic)
IS  - 1554-8600 (Linking)
VI  - 7
IP  - 6
DP  - 2011 Jun
TI  - Vaccines against viral hemorrhagic fevers: non-human primate models.
PG  - 667-73
AB  - Viral hemorrhagic fevers are a group of disease syndromes caused by infection
      with certain RNA viruses. The disease is marked by a febrile response, malaise,
      coagulopathy and vascular permeability culminating in death. Case fatality rates 
      can reach 90% depending on the etiologic agent. Currently, there is no approved
      antiviral treatment. Because of the high case fatality, risk of importation and
      the potential to use these agents as biological weapons, development of
      countermeasures to these agents is a high priority. The sporadic nature of
      disease outbreaks and the ethical issues associated with conducting a human trial
      for such diseases make human studies impractical; therefore, development of
      countermeasures must occur in relevant animal models. Non-human primates are
      superior models to study infectious disease because their immune system is
      similar to humans and they are good predictors of efficacy in vaccine development
      and other intervention strategies. This review article summarizes viral
      hemorrhagic fever non-human primate models.
FAU - Carrion, Ricardo Jr
AU  - Carrion R Jr
AD  - Department of Virology and Immunology, Southwest National Primate Research
      Center, Southwest Foundation for Biomedical Research, San Antonio, TX, USA.
FAU - Patterson, Jean L
AU  - Patterson JL
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110601
PL  - United States
TA  - Hum Vaccin
JT  - Human vaccines
JID - 101265291
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - *Disease Models, Animal
MH  - Hemorrhagic Fevers, Viral/*immunology
MH  - Humans
MH  - Primates
MH  - Viral Vaccines/*immunology
EDAT- 2011/03/30 06:00
MHDA- 2011/12/21 06:00
CRDT- 2011/03/30 06:00
PHST- 2011/03/30 06:00 [entrez]
PHST- 2011/03/30 06:00 [pubmed]
PHST- 2011/12/21 06:00 [medline]
AID - 14981 [pii]
AID - 10.4161/hv.7.6.14981 [doi]
PST - ppublish
SO  - Hum Vaccin. 2011 Jun;7(6):667-73. doi: 10.4161/hv.7.6.14981. Epub 2011 Jun 1.


PMID- 21444030
OWN - NLM
STAT- MEDLINE
DCOM- 20110718
LR  - 20110329
IS  - 1558-1977 (Electronic)
IS  - 0889-8588 (Linking)
VI  - 25
IP  - 2
DP  - 2011 Apr
TI  - Leukemia and lymphoma in pregnancy.
PG  - 277-91, vii
LID - 10.1016/j.hoc.2011.01.001 [doi]
AB  - Treatment of pregnant women with chemotherapy may pose a risk to the fetus,
      raising therapeutic, ethical, moral, and social dilemmas. Publications on this
      issue are limited to retrospective series and case reports, thus further
      complicating decision making. Diagnosis and staging are usually performed as in
      nonpregnant women, but procedures that expose the fetus to radiation are
      excluded. Chemotherapy is not recommended in the first trimester to avoid fetal
      malformations. Thus, the option is either treatment delay or pregnancy
      termination. Later in pregnancy, treatment is often initiated without delay, with
      no apparent evidence of teratogenicity.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Abadi, Uri
AU  - Abadi U
AD  - Department of Medicine, Hematology Institute, Meir Medical Center, Kfar Saba,
      Israel.
FAU - Koren, Gideon
AU  - Koren G
FAU - Lishner, Michael
AU  - Lishner M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Hematol Oncol Clin North Am
JT  - Hematology/oncology clinics of North America
JID - 8709473
SB  - IM
MH  - Age Factors
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Leukemia/epidemiology/physiopathology/*therapy
MH  - Lymphoma/epidemiology/physiopathology/*therapy
MH  - Male
MH  - Maternal-Fetal Exchange
MH  - Pregnancy
MH  - Pregnancy Complications, Hematologic/epidemiology/physiopathology/*therapy
MH  - Pregnancy Complications, Neoplastic/epidemiology/physiopathology/*therapy
EDAT- 2011/03/30 06:00
MHDA- 2011/07/19 06:00
CRDT- 2011/03/30 06:00
PHST- 2011/03/30 06:00 [entrez]
PHST- 2011/03/30 06:00 [pubmed]
PHST- 2011/07/19 06:00 [medline]
AID - S0889-8588(11)00003-7 [pii]
AID - 10.1016/j.hoc.2011.01.001 [doi]
PST - ppublish
SO  - Hematol Oncol Clin North Am. 2011 Apr;25(2):277-91, vii. doi:
      10.1016/j.hoc.2011.01.001.


PMID- 21443766
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1755-7682 (Electronic)
IS  - 1755-7682 (Linking)
VI  - 4
DP  - 2011 Mar 28
TI  - The essence of governance in health development.
PG  - 11
LID - 10.1186/1755-7682-4-11 [doi]
AB  - BACKGROUND: Governance and leadership in health development are critically
      important for the achievement of the health Millennium Development Goals (MDGs)
      and other national health goals. Those two factors might explain why many
      countries in Africa are not on track to attain the health MDGs by 2015. This
      paper debates the meaning of 'governance in health development', reviews briefly 
      existing governance frameworks, proposes a modified framework on health
      development governance (HDG), and develops a HDG index. DISCUSSION: We argue that
      unlike 'leadership in health development', 'governance in health development' is 
      the sole prerogative of the Government through the Ministry of Health, which can 
      choose to delegate (but not abrogate) some of the governance tasks. The general
      governance domains of the UNDP and the World Bank are very pertinent but not
      sufficient for assessment of health development governance. The WHO six domains
      of governance do not include effective external partnerships for health, equity
      in health development, efficiency in resource allocation and use, ethical
      practises in health research and service provision, and macroeconomic and
      political stability. The framework for assessing health systems governance
      developed by Siddiqi et al also does not include macroeconomic and political
      stability as a separate principle. The Siddiqi et al framework does not propose a
      way of scoring the various governance domains to facilitate aggregation,
      inter-country comparisons and health development governance tracking over
      time.This paper argues for a broader health development governance framework
      because other sectors that assure human rights to education, employment, food,
      housing, political participation, and security combined have greater impact on
      health development than the health systems. It also suggests some amendments to
      Siddigi et al's framework to make it more relevant to the broader concept of
      'governance in health development' and to the WHO African Region context.
      SUMMARY: A strong case for broader health development governance framework has
      been made. A health development governance index with 10 functions and 42
      sub-functions has been proposed to facilitate inter-country comparisons.
      Potential sources of data for estimating HDGI have been suggested. The Governance
      indices for individual sub-functions can aid policy-makers to establish the
      sources of weak health governance and subsequently develop appropriate
      interventions for ameliorating the situation.
FAU - Kirigia, Joses Muthuri
AU  - Kirigia JM
AD  - World Health Organization, Regional Office for Africa, B,P, 06, Brazzaville,
      Congo. kirigiaj@afro.who.int.
FAU - Kirigia, Doris Gatwiri
AU  - Kirigia DG
LA  - eng
PT  - Journal Article
DEP - 20110328
PL  - England
TA  - Int Arch Med
JT  - International archives of medicine
JID - 101317943
PMC - PMC3072323
EDAT- 2011/03/30 06:00
MHDA- 2011/03/30 06:01
CRDT- 2011/03/30 06:00
PHST- 2010/11/19 00:00 [received]
PHST- 2011/03/28 00:00 [accepted]
PHST- 2011/03/30 06:00 [entrez]
PHST- 2011/03/30 06:00 [pubmed]
PHST- 2011/03/30 06:01 [medline]
AID - 1755-7682-4-11 [pii]
AID - 10.1186/1755-7682-4-11 [doi]
PST - epublish
SO  - Int Arch Med. 2011 Mar 28;4:11. doi: 10.1186/1755-7682-4-11.


PMID- 21443492
OWN - NLM
STAT- MEDLINE
DCOM- 20120105
LR  - 20190911
IS  - 1875-5305 (Electronic)
IS  - 0929-8665 (Linking)
VI  - 18
IP  - 8
DP  - 2011 Aug
TI  - Protamine withdrawal from human sperm nuclei following heterologous ICSI into
      hamster oocytes.
PG  - 811-6
AB  - During late stages of spermatogenesis in mammals, most histones bound to DNA are 
      replaced by protamines (PRM), which results in formation of supercondensed and
      genetically inert sperm chromatin. At fertilization, mature spermatozoon
      penetrates oocyte and chromatin is remodeled "back" from nucleoprotamine to
      nucleohistone state. While being crucial for activation of male genome and
      ultimately for initiation of embryonic development, this process is poorly
      studied, especially in humans. Data on model animals concerning PRM to histones
      exchange post fertilization are few and contradictory. As direct experimentation 
      with human embryos is impossible due to ethical, legal and technical reasons, we 
      evaluate the timing and mode of PRM removal in a heterologous ICSI system using
      hamster ova injected with human sperm. Localization of human PRM 1 and 2 in
      hybrid zygotes was established using immunofluorescence. We observed a marked
      zygote to zygote variability in male pronuclei size for any time point post ICSI 
      and demonstrated that PRM removal correlates with the developing pronuclei area
      rather than time after injection. Overall, the disappearance of protamines from
      sperm is rather rapid and most likely completed within 1 hr. We propose that the 
      critical characteristic influencing PRM removal after heterologous fertilization 
      is the intrinsic heterogeneity of the human sperm population. The same yet
      unexplored variance may be one of the reasons for canceled, delayed or aberrant
      early embryonic development during natural or artificial fertilization in humans.
FAU - Jones, Estella L
AU  - Jones EL
AD  - The Jones Institute for Reproductive Medicine, Eastern Virginia Medical School,
      Norfolk, VA 23507, USA.
FAU - Zalensky, Andrei O
AU  - Zalensky AO
FAU - Zalenskaya, Irina A
AU  - Zalenskaya IA
LA  - eng
GR  - HD-042748/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Protein Pept Lett
JT  - Protein and peptide letters
JID - 9441434
RN  - 0 (Protamines)
SB  - IM
MH  - Animals
MH  - Cell Nucleus/chemistry/*metabolism
MH  - Cricetinae
MH  - Humans
MH  - Male
MH  - Microscopy, Fluorescence
MH  - Oocytes/*physiology
MH  - Protamines/chemistry/*metabolism
MH  - *Sperm Injections, Intracytoplasmic
MH  - Spermatozoa/chemistry/*metabolism
MH  - Zygote/chemistry/metabolism
EDAT- 2011/03/30 06:00
MHDA- 2012/01/06 06:00
CRDT- 2011/03/30 06:00
PHST- 2010/05/13 00:00 [received]
PHST- 2010/10/05 00:00 [accepted]
PHST- 2011/03/30 06:00 [entrez]
PHST- 2011/03/30 06:00 [pubmed]
PHST- 2012/01/06 06:00 [medline]
AID - BSP/ PPL/ E pub/0318 [pii]
AID - 10.2174/092986611795713925 [doi]
PST - ppublish
SO  - Protein Pept Lett. 2011 Aug;18(8):811-6. doi: 10.2174/092986611795713925.


PMID- 21442629
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20191210
IS  - 1097-0223 (Electronic)
IS  - 0197-3851 (Linking)
VI  - 31
IP  - 6
DP  - 2011 Jun
TI  - Monoamniotic twin pregnancy discordant for lethal open cranial defect: management
      dilemmas.
PG  - 578-82
LID - 10.1002/pd.2751 [doi]
AB  - OBJECTIVE: To report the sonographic findings, prenatal courses, and management
      options in four cases of monoamniotic twin pregnancy complicated by a discordant,
      lethal open cranial vault defect. METHODS: Cases were collected from two Latin
      American fetal medicine referral centers after the sonographic detection of a
      monoamniotic twin pregnancy in which one fetus was structurally normal and the
      other had a lethal open cranial vault defect. Three abnormal fetuses had
      acrania-anencephaly sequence and one had a large occipital encephalocele. The
      diagnosis was confirmed at referral, at which time umbilical cord entanglement
      was also diagnosed with color Doppler ultrasound in all cases. RESULTS: Two cases
      were managed with selective termination, one of which required referral to a
      fetal surgery center abroad because this option was illegal in Chile. The other
      case underwent radiofrequency ablation of the fetal intra-abdominal umbilical
      vessels after the corresponding ethics and legal committees approved the
      procedure. In both cases, the non-anomalous twin was born after 35 weeks and had 
      no perinatal complications. Expectant management was performed in the other two
      cases, resulting in the death of the normal twin at 25 weeks. CONCLUSIONS:
      Monoamniotic twin pregnancy discordant for severe cranial vault defect is a
      serious condition with a high risk of fetal demise of the structurally normal
      fetus. Our experience, although limited, suggests that aggressive management with
      selective termination of the abnormal twin and transection of its umbilical cord 
      in these cases may prevent the demise of the structurally normal co-twin.
CI  - Copyright (c) 2011 John Wiley & Sons, Ltd.
FAU - Sepulveda, Waldo
AU  - Sepulveda W
AD  - Maternal-Fetal Medicine Unit, Department of Obstetrics and Gynecology, San Jose
      Hospital, University of Santiago de Chile, Santiago, Chile. fetalmed@yahoo.com
FAU - Wong, Amy E
AU  - Wong AE
FAU - Sandoval, Rodrigo
AU  - Sandoval R
FAU - Aiello, Horacio
AU  - Aiello H
FAU - Otano, Lucas
AU  - Otano L
LA  - eng
PT  - Case Reports
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110327
PL  - England
TA  - Prenat Diagn
JT  - Prenatal diagnosis
JID - 8106540
SB  - IM
MH  - Abortion, Eugenic/methods
MH  - Adult
MH  - Anencephaly/diagnostic imaging/therapy
MH  - Diseases in Twins/diagnostic imaging/*therapy
MH  - Encephalocele/complications/congenital/therapy
MH  - Female
MH  - Humans
MH  - Pregnancy
MH  - *Pregnancy, Multiple
MH  - Prenatal Care/methods
MH  - Skull/*abnormalities/surgery
MH  - *Twins, Monozygotic
MH  - Ultrasonography, Prenatal
EDAT- 2011/03/29 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/03/29 06:00
PHST- 2010/09/27 00:00 [received]
PHST- 2011/02/16 00:00 [revised]
PHST- 2011/02/26 00:00 [accepted]
PHST- 2011/03/29 06:00 [entrez]
PHST- 2011/03/29 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - 10.1002/pd.2751 [doi]
PST - ppublish
SO  - Prenat Diagn. 2011 Jun;31(6):578-82. doi: 10.1002/pd.2751. Epub 2011 Mar 27.


PMID- 21442310
OWN - NLM
STAT- MEDLINE
DCOM- 20110729
LR  - 20110414
IS  - 1661-4917 (Electronic)
IS  - 0004-069X (Linking)
VI  - 59
IP  - 3
DP  - 2011 Jun
TI  - Ethical considerations in face transplantation: ethical issues related to
      inclusion criteria for face transplant candidates.
PG  - 157-9
LID - 10.1007/s00005-011-0121-6 [doi]
FAU - Siemionow, Maria
AU  - Siemionow M
LA  - eng
PT  - Editorial
DEP - 20110327
PL  - Switzerland
TA  - Arch Immunol Ther Exp (Warsz)
JT  - Archivum immunologiae et therapiae experimentalis
JID - 0114365
SB  - IM
MH  - *Ethics, Medical
MH  - Face/*surgery
MH  - Humans
MH  - Patient Selection/*ethics
MH  - Practice Guidelines as Topic
MH  - Quality of Life
MH  - *Surgery, Plastic
MH  - Tissue Donors/ethics/psychology
MH  - Tissue Transplantation/*ethics/psychology
MH  - United States
EDAT- 2011/03/29 06:00
MHDA- 2011/07/30 06:00
CRDT- 2011/03/29 06:00
PHST- 2011/03/15 00:00 [received]
PHST- 2011/03/17 00:00 [accepted]
PHST- 2011/03/29 06:00 [entrez]
PHST- 2011/03/29 06:00 [pubmed]
PHST- 2011/07/30 06:00 [medline]
AID - 10.1007/s00005-011-0121-6 [doi]
PST - ppublish
SO  - Arch Immunol Ther Exp (Warsz). 2011 Jun;59(3):157-9. doi:
      10.1007/s00005-011-0121-6. Epub 2011 Mar 27.


PMID- 21441972
OWN - NLM
STAT- MEDLINE
DCOM- 20110719
LR  - 20211020
IS  - 1995-8218 (Electronic)
IS  - 1995-8218 (Linking)
VI  - 27
IP  - 2
DP  - 2011 Apr
TI  - Induced pluripotent stem cells and neurodegenerative diseases.
PG  - 107-14
LID - 10.1007/s12264-011-1147-9 [doi]
AB  - Neurodegenerative diseases, including Parkinson's disease, Alzheimer's disease
      and Amyotrophic Lateral Sclerosis, are characterized by idiopathic neuron loss in
      different regions of the central nervous system, which contributes to the
      relevant dysfunctions in the patients. The application of cell replacement
      therapy using human embryonic stem (hES) cells, though having attracted much
      attention, has been hampered by the intrinsic ethical problems. It has been
      demonstrated that adult somatic cells can be reprogrammed into the embryonic
      state, called induced pluripotent stem (iPS) cells. It is soon realized that iPS 
      cells may be an alternative source for cell replacement therapy, because it
      raises no ethical problems and using patient-specific iPS cells for autologous
      transplantation will not lead to immunological rejection. What's more, certain
      types of neurons derived from patient-specific iPS cells may display
      disease-relevant phenotypes. Thus, patient-specific iPS cells can provide a
      unique opportunity to directly investigate the pathological properties of
      relevant neural cells in individual patient, and to study the vulnerability of
      neural cells to pathogenic factors in vitro, which may help reveal the
      pathogenesis of many neurodegenerative diseases. In this review, the recent
      development in cellular treatment of neurodegenerative diseases using iPS cells
      was summarized, and the potential value of iPS cells in the modeling of
      neurodegenerative disease was discussed.
FAU - Chen, Chao
AU  - Chen C
AD  - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 
      Shanghai 200030, China.
FAU - Xiao, Shi-Fu
AU  - Xiao SF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Singapore
TA  - Neurosci Bull
JT  - Neuroscience bulletin
JID - 101256850
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*physiology/*transplantation
MH  - Neurodegenerative Diseases/*surgery
PMC - PMC5560343
EDAT- 2011/03/29 06:00
MHDA- 2011/07/20 06:00
CRDT- 2011/03/29 06:00
PHST- 2011/03/29 06:00 [entrez]
PHST- 2011/03/29 06:00 [pubmed]
PHST- 2011/07/20 06:00 [medline]
AID - 10.1007/s12264-011-1147-9 [doi]
PST - ppublish
SO  - Neurosci Bull. 2011 Apr;27(2):107-14. doi: 10.1007/s12264-011-1147-9.


PMID- 21441762
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20130410
IS  - 2154-8331 (Print)
IS  - 2154-8331 (Linking)
VI  - 39
IP  - 1
DP  - 2011 Feb
TI  - The use of advance directives among patients with left ventricular assist
      devices.
PG  - 78-84
LID - 10.3810/hp.2011.02.377 [doi]
AB  - Patients who undergo implantation of left ventricular assist devices (LVADs)
      often have improved quality of life, but may eventually succumb to their heart
      failure and/or sustain LVAD-related complications. In end-of-life situations,
      decisions must be made about when to deactivate LVAD support. Previous studies
      have demonstrated that end-of-life planning, particularly with the use of advance
      directives (ADs), can clarify patients' end-of-life preferences when they are
      unable to speak for themselves. However, many patients do not have ADs, and among
      patients who do, the ADs may lack useful information on how to guide care
      surrogates and clinicians regarding patients' preferences on life-sustaining
      treatments. The authors retrospectively reviewed the charts of 68 patients with
      advanced heart failure (56 men [82%]; mean [standard deviation] age, 59.0 +/-
      12.2 years) who underwent LVAD implantation between March 2003 and January 2009. 
      The indication for the LVAD was destination therapy in 36 (53%) patients and
      bridge to heart transplant in 32 (47%) patients. Overall, 32 (47%) patients had
      ADs of varying types; 25 (78%) ADs were completed before LVAD implantation.
      Although life-sustaining treatments (eg, tube feeding, cardiopulmonary
      resuscitation, mechanical ventilation, and hemodialysis) were mentioned, none
      explicitly mentioned the LVAD or withdrawal of LVAD support at the end of life.
      We hypothesize that if instructions regarding LVAD management in ADs are
      explicit, surrogate and clinician distress may decrease, and ethical dilemmas may
      be avoided.
FAU - Swetz, Keith M
AU  - Swetz KM
AD  - Division of General Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.
      swetz.keith@mayo.edu
FAU - Mueller, Paul S
AU  - Mueller PS
FAU - Ottenberg, Abigale L
AU  - Ottenberg AL
FAU - Dib, Chadi
AU  - Dib C
FAU - Freeman, Monica R
AU  - Freeman MR
FAU - Sulmasy, Daniel P
AU  - Sulmasy DP
LA  - eng
PT  - Journal Article
PL  - England
TA  - Hosp Pract (1995)
JT  - Hospital practice (1995)
JID - 101268948
SB  - IM
MH  - *Advance Directives
MH  - Chi-Square Distribution
MH  - Female
MH  - *Heart-Assist Devices
MH  - Humans
MH  - Life Expectancy
MH  - Male
MH  - Middle Aged
MH  - Quality of Life
MH  - Statistics, Nonparametric
MH  - Ventricular Dysfunction, Left/*therapy
EDAT- 2011/03/29 06:00
MHDA- 2011/06/03 06:00
CRDT- 2011/03/29 06:00
PHST- 2011/03/29 06:00 [entrez]
PHST- 2011/03/29 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
AID - 10.3810/hp.2011.02.377 [doi]
PST - ppublish
SO  - Hosp Pract (1995). 2011 Feb;39(1):78-84. doi: 10.3810/hp.2011.02.377.


PMID- 21441691
OWN - NLM
STAT- MEDLINE
DCOM- 20110712
LR  - 20211020
IS  - 0971-5916 (Print)
IS  - 0971-5916 (Linking)
VI  - 133
DP  - 2011 Mar
TI  - Strengthening ethics in clinical research.
PG  - 339-40
FAU - Pandey, Arvind
AU  - Pandey A
FAU - Aggarwal, Abha
AU  - Aggarwal A
FAU - Seth, S D
AU  - Seth SD
FAU - Maulik, Mohua
AU  - Maulik M
FAU - Juneja, Atul
AU  - Juneja A
LA  - eng
PT  - Letter
PL  - India
TA  - Indian J Med Res
JT  - The Indian journal of medical research
JID - 0374701
SB  - IM
MH  - *Ethics, Medical
MH  - *Ethics, Research
PMC - PMC3103162
EDAT- 2011/03/29 06:00
MHDA- 2011/07/13 06:00
CRDT- 2011/03/29 06:00
PHST- 2011/03/29 06:00 [entrez]
PHST- 2011/03/29 06:00 [pubmed]
PHST- 2011/07/13 06:00 [medline]
AID - IndianJMedRes_2011_133_3_339_78381 [pii]
PST - ppublish
SO  - Indian J Med Res. 2011 Mar;133:339-40.


PMID- 21441632
OWN - NLM
STAT- MEDLINE
DCOM- 20110804
LR  - 20181201
IS  - 1881-6096 (Print)
IS  - 1881-6096 (Linking)
VI  - 63
IP  - 4
DP  - 2011 Apr
TI  - [Comprehensive management for women with epilepsy].
PG  - 301-8
AB  - Medical treatment of epilepsy is quite different for women than for men. It is
      known that estrogen facilitates while progesterone inhibits the generation of
      epileptic seizures. Due to the direct neuronal effects of estrogen, progesterone,
      and their metabolites, as well as the cyclic nature of sex hormone release, women
      are particularly susceptible to the effects of these hormones on seizure
      frequency and severity. Antiepileptic drugs (AEDs) may result in reproductive
      endocrine disorders, inhibition of sexuality, decrease in oral contraceptive
      effects, or congenital malformations. Results of a systematic literature review
      suggest that the overall incidence of the congenital malformations in children
      born to women with epilepsy is approximately three times that of healthy women.
      The risk is elevated in all patients receiving AED monotherapy and further
      elevated in those receiving AED polytherapy compared to women without epilepsy.
      Studies have shown that many of these risks can be minimized with appropriate
      treatment and preconception counseling. The present review article summarizes the
      comprehensive management of women with epilepsy from a bio-psycho-socio-ethical
      point of view.
FAU - Chiba, Shigeru
AU  - Chiba S
AD  - Department of Psychiatry and Neurology, School of Medicine, Asahikawa Medical
      University, Midorigaoka Higashi, Hokkaido, Japan.
LA  - jpn
PT  - Journal Article
PT  - Review
PT  - Systematic Review
PL  - Japan
TA  - Brain Nerve
JT  - Brain and nerve = Shinkei kenkyu no shinpo
JID - 101299709
RN  - 0 (Anticonvulsants)
RN  - 0 (Contraceptives, Oral, Hormonal)
RN  - 0 (Estrogens)
RN  - 4G7DS2Q64Y (Progesterone)
SB  - IM
MH  - Abnormalities, Drug-Induced/etiology
MH  - Anticonvulsants/*adverse effects/pharmacokinetics
MH  - *Comprehensive Health Care
MH  - Contraceptives, Oral, Hormonal
MH  - Counseling
MH  - Drug Interactions
MH  - Endocrine System Diseases/chemically induced
MH  - Epilepsy/epidemiology/*therapy
MH  - Estrogens/*physiology
MH  - Female
MH  - Humans
MH  - Pregnancy
MH  - Pregnancy Complications
MH  - Progesterone/*physiology
MH  - Risk
MH  - Sexuality/drug effects
EDAT- 2011/03/29 06:00
MHDA- 2011/08/05 06:00
CRDT- 2011/03/29 06:00
PHST- 2011/03/29 06:00 [entrez]
PHST- 2011/03/29 06:00 [pubmed]
PHST- 2011/08/05 06:00 [medline]
AID - 1416100873 [pii]
PST - ppublish
SO  - Brain Nerve. 2011 Apr;63(4):301-8.


PMID- 21441498
OWN - NLM
STAT- MEDLINE
DCOM- 20110803
LR  - 20110328
IS  - 1544-0737 (Electronic)
IS  - 0895-9374 (Linking)
VI  - 23
IP  - 1
DP  - 2011 Apr
TI  - Traditional medicines, HIV, and related infections: workshop 2C.
PG  - 159-64
LID - 10.1177/0022034511400077 [doi]
AB  - Traditional medicines are an integral part of health care worldwide, even though 
      their efficacy has not been scientifically proven. HIV-infected individuals may
      use them singularly or in combination with conventional medicines. Many in vitro 
      studies have proven the anti-HIV, anti-Candida, and anti-herpes simplex virus
      potential of traditional plants and identified some of the mechanisms of action. 
      Very few in vivo studies are available that involve a small number of
      participants and show controversial results. In addition, knowledge is limited of
      the role of traditional medicines in the enhancement of the immune system. The
      use of traditional medicines with antiretroviral drugs (ARVs) has created a
      problem because drug interactions compromise the efficacy of ARVs. Several
      currently popular plants have been studied in the laboratory for their
      interaction with ARVs, with disadvantageous results. Unfortunately, no clinical
      trials are available. The science of traditional medicines is relatively new and 
      is at present being modernized worldwide. However, there are still ethical issues
      regarding traditional medicines that need to be addressed-for example,
      regulations regarding quality control and standardization of medicines,
      regulation and education of healers who deliver these medicines, and unregulated 
      clinical trials. The workshop addressed the following questions about traditional
      medicine and their use in HIV infection: What are the mechanisms of action of
      anti-HIV traditional medicines? Should traditional medicines be used in
      conjunction with ARV? Do traditional medicines enhance the immune system? Should 
      medicinal plants be used for the control of oral infections associated with HIV? 
      What are the ethical issues surrounding the use of traditional medicines for the 
      treatment of HIV and associated infections?
FAU - Patel, M
AU  - Patel M
AD  - Department of Clinical Microbiology and Infectious Diseases, National Health
      Laboratory Services, and School of Pathology, University of the Witwatersrand,
      Johannesburg, South Africa. mrudula.patel@wits.ac.za
FAU - Bessong, P
AU  - Bessong P
FAU - Liu, H
AU  - Liu H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Adv Dent Res
JT  - Advances in dental research
JID - 8802131
RN  - 0 (Anti-HIV Agents)
RN  - 0 (Drug Combinations)
RN  - 0 (Drugs, Chinese Herbal)
MH  - AIDS-Related Opportunistic Infections/*drug therapy
MH  - Anti-HIV Agents/chemistry/pharmacology/*therapeutic use
MH  - Candida albicans/drug effects
MH  - Candidiasis, Oral/*drug therapy
MH  - Drug Combinations
MH  - Drugs, Chinese Herbal/chemistry/pharmacology/*therapeutic use
MH  - Ethics
MH  - Focus Groups
MH  - HIV Infections/*drug therapy
MH  - HIV-1/*drug effects
MH  - Humans
MH  - Leukoplakia, Hairy/drug therapy
MH  - Qi
MH  - Simplexvirus/drug effects
EDAT- 2011/03/29 06:00
MHDA- 2011/08/04 06:00
CRDT- 2011/03/29 06:00
PHST- 2011/03/29 06:00 [entrez]
PHST- 2011/03/29 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
AID - 23/1/159 [pii]
AID - 10.1177/0022034511400077 [doi]
PST - ppublish
SO  - Adv Dent Res. 2011 Apr;23(1):159-64. doi: 10.1177/0022034511400077.


PMID- 21441495
OWN - NLM
STAT- MEDLINE
DCOM- 20110803
LR  - 20151119
IS  - 1544-0737 (Electronic)
IS  - 0895-9374 (Linking)
VI  - 23
IP  - 1
DP  - 2011 Apr
TI  - Mucosal fluids and biomarkers of clinical disease: workshop 3B.
PG  - 137-41
LID - 10.1177/0022034511400078 [doi]
AB  - Diagnostic tests for a range of oral and systemic diseases using fluids sampled
      from the mouth are under intense investigation and are increasingly being used.
      Methods exist for identification of HIV antibody and nucleic acid and for other
      viral infections of the mouth, such as Kaposi sarcoma herpes virus or human
      herpesvirus-8, which may coexist with HIV. A number of commercial test kits are
      available, with variable evidence of sensitivity, specificity, and utility. There
      is intense research on sophisticated but potentially facile handheld in-office
      devices for many disease markers. Challenges to their uptake require
      well-designed studies on their practical reliability and utility, with
      appropriate controls. A range of ethical, social, and political issues need to be
      addressed in such studies.
FAU - Johnson, N W
AU  - Johnson NW
AD  - Griffith Institute for Health and Medical Research and Griffith Medical Research 
      College, Griffith University, Queensland, Australia. n.johnson@griffith.edu.au.
FAU - Malamud, D
AU  - Malamud D
FAU - Reznik, D
AU  - Reznik D
FAU - Speicher, D J
AU  - Speicher DJ
FAU - Phelan, J
AU  - Phelan J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Adv Dent Res
JT  - Advances in dental research
JID - 8802131
RN  - 0 (Biomarkers)
RN  - 0 (RNA, Viral)
MH  - Biomarkers/analysis
MH  - Focus Groups
MH  - HIV Infections/complications/*diagnosis
MH  - HIV-1/isolation & purification
MH  - Herpesvirus 8, Human/isolation & purification
MH  - Humans
MH  - Immunologic Tests
MH  - Lab-On-A-Chip Devices
MH  - Mass Screening/methods
MH  - Mouth Diseases/complications/*diagnosis/virology
MH  - Mouth Neoplasms/complications/diagnosis/virology
MH  - RNA, Viral/*analysis
MH  - Saliva/chemistry/*virology
MH  - Sarcoma, Kaposi/complications/*diagnosis/virology
MH  - Sensitivity and Specificity
EDAT- 2011/03/29 06:00
MHDA- 2011/08/04 06:00
CRDT- 2011/03/29 06:00
PHST- 2011/03/29 06:00 [entrez]
PHST- 2011/03/29 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
AID - 23/1/137 [pii]
AID - 10.1177/0022034511400078 [doi]
PST - ppublish
SO  - Adv Dent Res. 2011 Apr;23(1):137-41. doi: 10.1177/0022034511400078.


PMID- 21441492
OWN - NLM
STAT- MEDLINE
DCOM- 20110803
LR  - 20110328
IS  - 1544-0737 (Electronic)
IS  - 0895-9374 (Linking)
VI  - 23
IP  - 1
DP  - 2011 Apr
TI  - Social aspects of HIV and their relationship to craniofacial problems: workshop
      4C.
PG  - 117-21
LID - 10.1177/0022034511400223 [doi]
AB  - The oral research community needs an understanding of the social causes,
      consequences, and costs of disease in relation to oral health. This workshop
      concluded that HIV infection constitutes a special dental need requiring specific
      arrangements to facilitate oral care for infected persons. Oral manifestations of
      HIV infection affect everyday life, but more evidence is needed on the effects of
      interventions to alleviate these impacts. Other oral health habits add to the
      burden of HIV/AIDS-associated oral diseases and compete with them for resources. 
      These problems are most acute where the prevalence of HIV is high and resources
      are scarce. Effective health promotion is therefore important in these areas.
      Without data on the utility of oral health care in developing countries,
      practical approaches are guided by societal and multidisciplinary principles.
      There are also important ethical considerations.
FAU - Umadevi, K R
AU  - Umadevi KR
AD  - Oral Pathology, Ragas Dental College, Chennai, India.
FAU - Blignaut, E
AU  - Blignaut E
FAU - Glick, M
AU  - Glick M
FAU - Nasir, E
AU  - Nasir E
FAU - Yengopal, V
AU  - Yengopal V
FAU - Younai, F
AU  - Younai F
FAU - Robinson, P G
AU  - Robinson PG
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Adv Dent Res
JT  - Advances in dental research
JID - 8802131
MH  - Areca
MH  - Clinical Trials as Topic/*ethics
MH  - Cost of Illness
MH  - Cost-Benefit Analysis
MH  - Cultural Competency
MH  - *Dental Care for Chronically Ill
MH  - *Developing Countries
MH  - Focus Groups
MH  - HIV Infections/complications/*psychology
MH  - Humans
MH  - Informed Consent/ethics
MH  - *Quality of Life
MH  - Resource Allocation
MH  - Smoking
MH  - Socioeconomic Factors
MH  - Substance-Related Disorders/complications
EDAT- 2011/03/29 06:00
MHDA- 2011/08/04 06:00
CRDT- 2011/03/29 06:00
PHST- 2011/03/29 06:00 [entrez]
PHST- 2011/03/29 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
AID - 23/1/117 [pii]
AID - 10.1177/0022034511400223 [doi]
PST - ppublish
SO  - Adv Dent Res. 2011 Apr;23(1):117-21. doi: 10.1177/0022034511400223.


PMID- 21441491
OWN - NLM
STAT- MEDLINE
DCOM- 20110803
LR  - 20110328
IS  - 1544-0737 (Electronic)
IS  - 0895-9374 (Linking)
VI  - 23
IP  - 1
DP  - 2011 Apr
TI  - Oral lesions, HIV phenotypes, and management of HIV-related disease: Workshop 4A.
PG  - 112-6
LID - 10.1177/0022034511400079 [doi]
AB  - The workshop considered 5 questions related to oral lesions, HIV phenotypes, and 
      the management of HIV-related disease, with a focus on evidence and challenges in
      resource-poor settings. First, are oral lesions unique with respect to geographic
      location or phenotype? Second, how useful would an oral lesion index be to
      predict HIV in resource-poor countries with no access to CD4 counts or viral
      load? Third, what are the latest methods and delivery modes for drugs used to
      treat oral lesions associated with HIV? Fourth, what is the role of the oral
      health care worker in rapid diagnostic testing for HIV? Fifth, what ethical and
      legal issues are to be considered when managing the HIV patient? The consensus of
      the workshop was the need for additional research in 4 key areas in developing
      countries: (1) additional investigation of comorbidities associated with HIV
      infection that may affect oral lesion presentation and distribution, especially
      in pediatric populations; (2) the development of region-specific algorithms
      involving HIV oral lesions, indicating cumulative risk of immune suppression and 
      the presence of HIV disease; (3) well-designed clinical trials to test new
      therapies for oral lesions, new treatments for resistant oral fungal and viral
      diseases, effectiveness of therapies in children, and new drug delivery systems; 
      and (4) the role of the oral health care worker in rapid diagnostic testing for
      HIV in various regions of the world.
FAU - Patton, L L
AU  - Patton LL
AD  - Department of Dental Ecology, School of Dentistry, University of North Carolina, 
      Chapel Hill, North Carolina, USA. Lauren_Patton@dentistry.unc.edu
FAU - Ranganathan, K
AU  - Ranganathan K
FAU - Naidoo, S
AU  - Naidoo S
FAU - Bhayat, A
AU  - Bhayat A
FAU - Balasundaram, S
AU  - Balasundaram S
FAU - Adeyemi, O
AU  - Adeyemi O
FAU - Taiwo, O
AU  - Taiwo O
FAU - Speicher, D J
AU  - Speicher DJ
FAU - Chandra, L
AU  - Chandra L
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Adv Dent Res
JT  - Advances in dental research
JID - 8802131
MH  - Caregivers/ethics
MH  - Dental Care for Chronically Ill/ethics
MH  - *Developing Countries
MH  - Disease Transmission, Infectious/prevention & control
MH  - Drug Delivery Systems
MH  - Focus Groups
MH  - HIV Infections/*complications/diagnosis/drug therapy/epidemiology
MH  - HIV-1/classification/*genetics
MH  - HIV-2/classification/genetics
MH  - Health Resources
MH  - Humans
MH  - Informed Consent
MH  - Molecular Epidemiology
MH  - Mouth Diseases/*complications/diagnosis/drug therapy
MH  - Mouth Mucosa/*pathology/virology
MH  - Phenotype
MH  - Treatment Refusal
EDAT- 2011/03/29 06:00
MHDA- 2011/08/04 06:00
CRDT- 2011/03/29 06:00
PHST- 2011/03/29 06:00 [entrez]
PHST- 2011/03/29 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
AID - 23/1/112 [pii]
AID - 10.1177/0022034511400079 [doi]
PST - ppublish
SO  - Adv Dent Res. 2011 Apr;23(1):112-6. doi: 10.1177/0022034511400079.


PMID- 21441308
OWN - NLM
STAT- MEDLINE
DCOM- 20110912
LR  - 20220427
IS  - 1477-0873 (Electronic)
IS  - 0269-2155 (Linking)
VI  - 25
IP  - 6
DP  - 2011 Jun
TI  - A systematic review and synthesis of the quantitative and qualitative evidence
      behind patient-centred goal setting in stroke rehabilitation.
PG  - 501-14
LID - 10.1177/0269215510394467 [doi]
AB  - OBJECTIVE: To map out from the literature the nature, extent and effects of
      application of patient-centred goal setting in stroke rehabilitation practice.
      DESIGN: Systematic review. DATA SOURCES: A search was conducted in the Cochrane
      (Wiley), AMED, Medline (EBSCO), Embase, Sports discuss, Medline (Ovid) and CINAHL
      databases. Secondary search based on references from the preliminary search was
      undertaken. REVIEW METHODS: Quantitative and qualitative studies that included
      aspects of patient-centredness and goal setting in stroke patients from 1980 to
      June 2010 were collected. Studies were scrutinized for relevance and quality
      based on published methodology. The findings were synthesized by aggregating the 
      themes from the qualitative studies and relating them to relevant findings from
      the quantitative studies. RESULTS: Eighteen qualitative and eight quantitative
      and one mixed method study conducted in stroke rehabilitation services ranging
      from acute to community rehabilitation were included. Themes that emerged were
      related to perceptions of patients and professionals regarding
      patient-centredness, nominal adoption of this concept, consequences of
      discrepancies in the perceptions and practice, related ethical conflicts,
      challenges to application and strategies to improve its application. The effects 
      of following patient-centred goal-setting practice have been studied mostly with 
      weak methodologies and studies show some benefit with psychological outcomes.
      CONCLUSION: Patient-centred goal setting is minimally adopted in goal-setting
      practice due to various barriers. Since the effects of incorporating this concept
      have not been evaluated rigorously it is suggested that further research is
      essential to investigate its effect on patient outcomes.
FAU - Rosewilliam, Sheeba
AU  - Rosewilliam S
AD  - School of Health and Population Sciences-Nursing and Physiotherapy, University of
      Birmingham, UK. s.b.rosewilliam@bham.ac.uk
FAU - Roskell, Carolyn Anne
AU  - Roskell CA
FAU - Pandyan, A D
AU  - Pandyan AD
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20110325
PL  - England
TA  - Clin Rehabil
JT  - Clinical rehabilitation
JID - 8802181
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Databases, Bibliographic
MH  - Evaluation Studies as Topic
MH  - Goals
MH  - Humans
MH  - Patient Participation/*psychology
MH  - *Patient Preference
MH  - Patient-Centered Care
MH  - Perception
MH  - *Professional-Patient Relations
MH  - Qualitative Research
MH  - *Stroke Rehabilitation
EDAT- 2011/03/29 06:00
MHDA- 2011/09/13 06:00
CRDT- 2011/03/29 06:00
PHST- 2011/03/29 06:00 [entrez]
PHST- 2011/03/29 06:00 [pubmed]
PHST- 2011/09/13 06:00 [medline]
AID - 0269215510394467 [pii]
AID - 10.1177/0269215510394467 [doi]
PST - ppublish
SO  - Clin Rehabil. 2011 Jun;25(6):501-14. doi: 10.1177/0269215510394467. Epub 2011 Mar
      25.


PMID- 21441112
OWN - NLM
STAT- MEDLINE
DCOM- 20140211
LR  - 20220410
IS  - 1544-2217 (Electronic)
IS  - 0300-9858 (Linking)
VI  - 49
IP  - 2
DP  - 2012 Mar
TI  - Swine as models in biomedical research and toxicology testing.
PG  - 344-56
LID - 10.1177/0300985811402846 [doi]
AB  - Swine are considered to be one of the major animal species used in translational 
      research, surgical models, and procedural training and are increasingly being
      used as an alternative to the dog or monkey as the choice of nonrodent species in
      preclinical toxicologic testing of pharmaceuticals. There are unique advantages
      to the use of swine in this setting given that they share with humans similar
      anatomic and physiologic characteristics involving the cardiovascular, urinary,
      integumentary, and digestive systems. However, the investigator needs to be
      familiar with important anatomic, histopathologic, and clinicopathologic features
      of the laboratory pig and minipig in order to put background lesions or
      xenobiotically induced toxicologic changes in their proper perspective and also
      needs to consider specific anatomic differences when using the pig as a surgical 
      model. Ethical considerations, as well as the existence of significant amounts of
      background data, from a regulatory perspective, provide further support for the
      use of this species in experimental or pharmaceutical research studies. It is
      likely that pigs and minipigs will become an increasingly important animal model 
      for research and pharmaceutical development applications.
FAU - Swindle, M M
AU  - Swindle MM
AD  - Medical University of South Carolina, Department of Comparative Medicine, MSC
      777, 114 Doughty St, Charleston, SC 29425-7770, USA. swindlem@musc.edu
FAU - Makin, A
AU  - Makin A
FAU - Herron, A J
AU  - Herron AJ
FAU - Clubb, F J Jr
AU  - Clubb FJ Jr
FAU - Frazier, K S
AU  - Frazier KS
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110325
PL  - United States
TA  - Vet Pathol
JT  - Veterinary pathology
JID - 0312020
SB  - IM
EIN - Vet Pathol. 2012 Jul;49(4):738
MH  - Animal Use Alternatives
MH  - Animals
MH  - Biomedical Research
MH  - Drug-Related Side Effects and Adverse Reactions
MH  - Female
MH  - Humans
MH  - Male
MH  - *Models, Animal
MH  - *Sus scrofa/anatomy & histology/physiology
MH  - Swine
MH  - *Swine, Miniature/anatomy & histology/physiology
MH  - Toxicity Tests
EDAT- 2011/03/29 06:00
MHDA- 2014/02/12 06:00
CRDT- 2011/03/29 06:00
PHST- 2011/03/29 06:00 [entrez]
PHST- 2011/03/29 06:00 [pubmed]
PHST- 2014/02/12 06:00 [medline]
AID - 0300985811402846 [pii]
AID - 10.1177/0300985811402846 [doi]
PST - ppublish
SO  - Vet Pathol. 2012 Mar;49(2):344-56. doi: 10.1177/0300985811402846. Epub 2011 Mar
      25.


PMID- 21440275
OWN - NLM
STAT- MEDLINE
DCOM- 20110929
LR  - 20161109
IS  - 1578-178X (Electronic)
IS  - 0033-8338 (Linking)
VI  - 53
IP  - 2
DP  - 2011 Mar-Apr
TI  - [Formal training in medical journalism: why, who, when, how?].
PG  - 108-15
LID - 10.1016/j.rx.2011.01.002 [doi]
AB  - Despite the proliferation of journals and the demanding responsibilities of an
      editorship, there are very few clearly delineated standards for editorial
      education. The editor of a medical journal has a challenging role. He or she must
      deal with scientific decisions and appraisals that require skill in both writing 
      and critical review. But the editor also has to cope with other concerns,
      including ethical issues, opposition within the editorial board, and conflict
      with disgruntled authors. The editor has also to design the journal's future, and
      make decisions considering the strategic interest of the journal and the needs of
      the journal's readers. In this paper, we examine the medical editor's role,
      review the topic of education for those interested in medical editorial work and 
      discuss the tenets and structure of existing medical editorial training programs.
CI  - Copyright (c) 2010 SERAM. Published by Elsevier Espana. All rights reserved.
FAU - Heller, Samantha Lynn
AU  - Heller SL
AD  - Department of Radiology, New York University Medical Center, Nueva York, Estados 
      Unidos.
FAU - Garcia Santos, Jose Maria
AU  - Garcia Santos JM
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Formacion reglada en editorialismo medico: inverted question markpor que, quien, 
      cuando, como?
DEP - 20110325
PL  - Spain
TA  - Radiologia
JT  - Radiologia
JID - 0120775
SB  - IM
MH  - *Education, Professional/standards
MH  - Fellowships and Scholarships
MH  - *Journalism, Medical
MH  - Publishing
EDAT- 2011/03/29 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/03/29 06:00
PHST- 2010/12/10 00:00 [received]
PHST- 2011/01/20 00:00 [revised]
PHST- 2011/01/24 00:00 [accepted]
PHST- 2011/03/29 06:00 [entrez]
PHST- 2011/03/29 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - S0033-8338(11)00049-X [pii]
AID - 10.1016/j.rx.2011.01.002 [doi]
PST - ppublish
SO  - Radiologia. 2011 Mar-Apr;53(2):108-15. doi: 10.1016/j.rx.2011.01.002. Epub 2011
      Mar 25.


PMID- 21440113
OWN - NLM
STAT- MEDLINE
DCOM- 20110526
LR  - 20110328
IS  - 1552-6259 (Electronic)
IS  - 0003-4975 (Linking)
VI  - 91
IP  - 4
DP  - 2011 Apr
TI  - Partial anomalous pulmonary venous connection to the superior vena cava.
PG  - e64-6
LID - 10.1016/j.athoracsur.2010.12.007 [doi]
AB  - We describe the surgical technique of reimplantation of the right superior
      pulmonary vein into the left atrium in 2 patients with partial anomalous
      pulmonary venous connection to the superior vena cava without atrial septal
      defect. A right axillary minithoracotomy is done through the fourth intercostal
      space. The pulmonary vein is detached from its origin in the superior vena cava. 
      This is sutured with 6-0 reabsorbable polydioxanone suture (Ethicon, Somerville, 
      NJ). A lateral clamp is applied to the left atrium, and the pulmonary vein is
      reimplanted. The patient is extubated in the operating room. Neither
      cardiopulmonary bypass nor blood transfusion was required. It is simple, safe,
      and reproducible.
CI  - Copyright (c) 2011 The Society of Thoracic Surgeons. Published by Elsevier Inc.
      All rights reserved.
FAU - Aramendi, Jose I
AU  - Aramendi JI
AD  - Division of Cardiac Surgery, Hospital De Cruces, Barakaldo, Spain.
      ji.aramendi@terra.es
FAU - Rey, Estibaliz
AU  - Rey E
FAU - Hamzeh, Gadah
AU  - Hamzeh G
FAU - Crespo, Alejandro
AU  - Crespo A
FAU - Luis, Maite
AU  - Luis M
FAU - Voces, Roberto
AU  - Voces R
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Ann Thorac Surg
JT  - The Annals of thoracic surgery
JID - 15030100R
SB  - IM
MH  - Abnormalities, Multiple/*surgery
MH  - Child
MH  - Humans
MH  - Pulmonary Veins/*abnormalities/*surgery
MH  - Vascular Surgical Procedures/methods
MH  - Vena Cava, Superior/*abnormalities/*surgery
EDAT- 2011/03/29 06:00
MHDA- 2011/05/27 06:00
CRDT- 2011/03/29 06:00
PHST- 2010/11/06 00:00 [received]
PHST- 2010/11/25 00:00 [revised]
PHST- 2010/12/07 00:00 [accepted]
PHST- 2011/03/29 06:00 [entrez]
PHST- 2011/03/29 06:00 [pubmed]
PHST- 2011/05/27 06:00 [medline]
AID - S0003-4975(10)02753-0 [pii]
AID - 10.1016/j.athoracsur.2010.12.007 [doi]
PST - ppublish
SO  - Ann Thorac Surg. 2011 Apr;91(4):e64-6. doi: 10.1016/j.athoracsur.2010.12.007.


PMID- 21439602
OWN - NLM
STAT- MEDLINE
DCOM- 20110928
LR  - 20110418
IS  - 1776-257X (Electronic)
IS  - 0035-1768 (Linking)
VI  - 112
IP  - 2
DP  - 2011 Apr
TI  - [From the first face replants operations to the first total face transplant: the 
      history of surgical prowess].
PG  - 93-100
LID - 10.1016/j.stomax.2011.02.006 [doi]
AB  - Composite tissue allografts of the face were considered as science-fiction just a
      decade ago. They have become wonderful realities in our hospitals. Face
      transplantation is one of the great scientific adventures of the 21(th) century
      that history will remember. Physicians dreamed to give a new face to disfigured
      patients. Allografts of the face have become a reality thanks to breakthroughs in
      anatomy and plastic surgery, HLA system research, microsurgery, neurology, and
      immunosuppressive molecules. In 2010, two teams performed the first total face
      transplants in the world. They represent technical milestones in the history of
      transplantation. These face transplants, which have raised a lot of controversy
      and ethical questions, open the way for other surgical perspectives, allowing
      medicine to write new history, and show that progress is also made through
      transgression.
CI  - Copyright (c) 2011 Elsevier Masson SAS. All rights reserved.
FAU - Pirnay, P
AU  - Pirnay P
AD  - Laboratoire d'ethique medicale et de medecine legale, faculte de medecine,
      universite Paris Descartes, 45, rue des Saints-Peres, Paris 75006, France.
      drphp1@orange.fr
FAU - Herve, C
AU  - Herve C
FAU - Meningaud, J-P
AU  - Meningaud JP
LA  - fre
PT  - English Abstract
PT  - Historical Article
PT  - Journal Article
TT  - Des premieres reimplantations aux premieres transplantations totales de la face: 
      l'histoire de prouesses chirurgicales.
DEP - 20110324
PL  - France
TA  - Rev Stomatol Chir Maxillofac
JT  - Revue de stomatologie et de chirurgie maxillo-faciale
JID - 0201010
SB  - IM
MH  - Face/*surgery
MH  - Facial Transplantation/*history
MH  - History, 16th Century
MH  - History, 17th Century
MH  - History, 18th Century
MH  - History, 19th Century
MH  - History, 20th Century
MH  - History, 21st Century
MH  - History, Medieval
MH  - Humans
MH  - Reconstructive Surgical Procedures/*history
MH  - Transplantation, Homologous
EDAT- 2011/03/29 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/03/29 06:00
PHST- 2010/12/09 00:00 [received]
PHST- 2011/01/27 00:00 [revised]
PHST- 2011/02/23 00:00 [accepted]
PHST- 2011/03/29 06:00 [entrez]
PHST- 2011/03/29 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - S0035-1768(11)00043-X [pii]
AID - 10.1016/j.stomax.2011.02.006 [doi]
PST - ppublish
SO  - Rev Stomatol Chir Maxillofac. 2011 Apr;112(2):93-100. doi:
      10.1016/j.stomax.2011.02.006. Epub 2011 Mar 24.


PMID- 21439434
OWN - NLM
STAT- MEDLINE
DCOM- 20110803
LR  - 20110328
IS  - 1558-4488 (Electronic)
IS  - 0270-9295 (Linking)
VI  - 31
IP  - 2
DP  - 2011 Mar
TI  - Peritoneal dialysis in infants and young children.
PG  - 213-24
LID - 10.1016/j.semnephrol.2011.01.009 [doi]
AB  - Although end-stage renal disease is rare in infants and young children, its
      development can be associated with significant morbidity and mortality and only
      through the provision of experienced, multidisciplinary care can a favorable
      outcome be anticipated. Peritoneal dialysis is the renal replacement modality of 
      choice for this age group and serves as an essential bridge until successful
      renal transplantation can occur. In this review, we discuss the practice of
      peritoneal dialysis in infants including the unique ethical and technical
      considerations facing pediatric nephrologists and caregivers. In addition, we
      review current guidelines concerning nutrition, growth, and adequacy, as well as 
      the literature on complications and outcomes.
CI  - Copyright (c) 2011. Published by Elsevier Inc.
FAU - Zaritsky, Joshua
AU  - Zaritsky J
AD  - Department of Pediatrics, David Geffen School of Medicine at University of
      California Los Angeles, Los Angeles, CA, USA.
FAU - Warady, Bradley A
AU  - Warady BA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Semin Nephrol
JT  - Seminars in nephrology
JID - 8110298
RN  - 0 (Dialysis Solutions)
SB  - IM
MH  - Catheters, Indwelling
MH  - Child Development
MH  - Child Nutritional Physiological Phenomena
MH  - Child, Preschool
MH  - Dialysis Solutions
MH  - Humans
MH  - Infant
MH  - Kidney Failure, Chronic/physiopathology/therapy
MH  - *Peritoneal Dialysis/adverse effects/ethics/instrumentation/methods
EDAT- 2011/03/29 06:00
MHDA- 2011/08/04 06:00
CRDT- 2011/03/29 06:00
PHST- 2011/03/29 06:00 [entrez]
PHST- 2011/03/29 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
AID - S0270-9295(11)00026-X [pii]
AID - 10.1016/j.semnephrol.2011.01.009 [doi]
PST - ppublish
SO  - Semin Nephrol. 2011 Mar;31(2):213-24. doi: 10.1016/j.semnephrol.2011.01.009.


PMID- 21439306
OWN - NLM
STAT- MEDLINE
DCOM- 20110929
LR  - 20220410
IS  - 1873-507X (Electronic)
IS  - 0031-9384 (Linking)
VI  - 103
IP  - 5
DP  - 2011 Jul 6
TI  - Breakfast consumption and cognitive function in adolescent schoolchildren.
PG  - 431-9
LID - 10.1016/j.physbeh.2011.03.018 [doi]
AB  - This study examined the effects of breakfast consumption on cognitive function,
      mood and blood glucose concentration in adolescent schoolchildren. With the
      institution's ethical advisory committee approval, 96 adolescents (12 to 15 years
      old) completed two randomly assigned trials (one following breakfast consumption 
      and one following breakfast omission), scheduled 7 days apart. Cognitive function
      tests (visual search test, Stroop test and Sternberg paradigm), a mood
      questionnaire and a finger prick blood sample (in a subgroup of 60 participants) 
      were completed immediately following breakfast and 120 min after the baseline
      measures. Following breakfast consumption, accuracy on the more complex level of 
      the visual search test was higher than following breakfast omission (p=0.021).
      Similarly, accuracy on the Stroop test was better maintained across the morning
      following breakfast consumption when compared to breakfast omission (p=0.022).
      Furthermore, responses on the Sternberg paradigm were quicker later in the
      morning following breakfast consumption, particularly on the more complex levels 
      (p=0.012). Breakfast consumption also produced higher self-report energy and
      fullness, lower self-report tiredness and hunger and higher blood glucose
      concentrations (all p<0.0005). Overall, the findings of the present study suggest
      that breakfast consumption enhances cognitive function in an adolescent
      population when compared to breakfast omission.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Cooper, Simon B
AU  - Cooper SB
AD  - Institute of Youth Sport, School of Sport, Exercise & Health Sciences,
      Loughborough University, Leicestershire, LE11 3TU, UK. S.B.Cooper@lboro.ac.uk
FAU - Bandelow, Stephan
AU  - Bandelow S
FAU - Nevill, Mary E
AU  - Nevill ME
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20110323
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adolescent
MH  - Adolescent Behavior/physiology/*psychology
MH  - Adolescent Nutritional Physiological Phenomena/*physiology
MH  - Affect/physiology
MH  - Blood Glucose/physiology
MH  - Child
MH  - Cognition/*physiology
MH  - Eating/*physiology/*psychology
MH  - Female
MH  - Humans
MH  - Male
MH  - Population
MH  - Psychomotor Performance/physiology
MH  - Reaction Time/physiology
MH  - Self Report
EDAT- 2011/03/29 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/03/29 06:00
PHST- 2010/07/28 00:00 [received]
PHST- 2011/01/21 00:00 [revised]
PHST- 2011/03/16 00:00 [accepted]
PHST- 2011/03/29 06:00 [entrez]
PHST- 2011/03/29 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - S0031-9384(11)00137-5 [pii]
AID - 10.1016/j.physbeh.2011.03.018 [doi]
PST - ppublish
SO  - Physiol Behav. 2011 Jul 6;103(5):431-9. doi: 10.1016/j.physbeh.2011.03.018. Epub 
      2011 Mar 23.


PMID- 21439213
OWN - NLM
STAT- MEDLINE
DCOM- 20110803
LR  - 20211020
IS  - 2769-6677 (Electronic)
IS  - 1559-6109 (Linking)
VI  - 50
IP  - 2
DP  - 2011 Mar
TI  - Evaluation of a sustained-release formulation of buprenorphine for analgesia in
      rats.
PG  - 198-204
AB  - Preventing and minimizing pain in laboratory animals is a basic tenet of
      biomedical research and is warranted for ethical, legal, and scientific reasons. 
      Postoperative analgesia is an important facet of pain management. A
      sustained-release formulation of buprenorphine was tested in rats for analgesic
      efficacy and plasma concentration over a 72-h time period. Rats were injected
      subcutaneously with either 1.2 mg/kg sustained-release formulation (Bup-SR), 0.2 
      mL/kg buprenorphine HCl (Bup-HCl), or an equivalent volume of sustained-release
      vehicle and tested in a thermal nociception model or a surgical postoperative
      pain model. In both models, Bup-SR showed evidence of providing analgesia for 2
      to 3 d. Thermal latency response in rats that received the sustained-release
      formulation increased 28.4% and 15.6% compared with baseline values on days 1 and
      2, respectively. Rats with a unicortical tibial defect and treated with Bup-SR
      showed similar willingness to bear weight on the hindlimbs as did
      negative-control animals (no surgery), demonstrated by counting vertical raises; 
      rats treated with Bup-HCl had significantly fewer vertical raises than did
      control rats for 5 d after surgery. Plasma concentrations of buprenorphine
      remained over 1 ng/mL for 72 h after a single dose of Bup-SR. Taken together, the
      results indicate that this formulation of buprenorphine may be a viable option
      for treating postsurgical pain in laboratory rats.
FAU - Foley, Patricia L
AU  - Foley PL
AD  - Office of Animal Welfare, University of Virginia, Charlottesville, Virginia, USA.
      plf6z@virginia.edu
FAU - Liang, Haixiang
AU  - Liang H
FAU - Crichlow, Andrew R
AU  - Crichlow AR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Am Assoc Lab Anim Sci
JT  - Journal of the American Association for Laboratory Animal Science : JAALAS
JID - 101269489
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Drug Combinations)
RN  - 40D3SCR4GZ (Buprenorphine)
SB  - IM
MH  - Analgesia/methods/*veterinary
MH  - Analgesics, Opioid/blood/*pharmacology
MH  - Animals
MH  - Buprenorphine/blood/*pharmacology
MH  - Delayed-Action Preparations/pharmacology
MH  - Drug Combinations
MH  - Injections, Subcutaneous/veterinary
MH  - Male
MH  - Pain Measurement/*veterinary
MH  - Pain, Postoperative/drug therapy/*veterinary
MH  - *Rats
MH  - Rats, Sprague-Dawley
PMC - PMC3061420
EDAT- 2011/03/29 06:00
MHDA- 2011/08/04 06:00
CRDT- 2011/03/29 06:00
PHST- 2011/03/29 06:00 [entrez]
PHST- 2011/03/29 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
PST - ppublish
SO  - J Am Assoc Lab Anim Sci. 2011 Mar;50(2):198-204.


PMID- 21439178
OWN - NLM
STAT- MEDLINE
DCOM- 20110527
LR  - 20211020
IS  - 1478-5242 (Electronic)
IS  - 0960-1643 (Linking)
VI  - 61
IP  - 585
DP  - 2011 Apr
TI  - Seeking ethical approval for an international study in primary care patient
      safety.
PG  - 197-204
LID - 10.3399/bjgp11X567144 [doi]
AB  - Seeking ethics committee approval for research can be challenging even for
      relatively simple studies occurring in single settings. Complicating factors such
      as multicentre studies and/or contentious research issues can challenge review
      processes, and conducting such studies internationally adds a further layer of
      complexity. This paper draws on the experiences of the LINNAEUS Collaboration, an
      international group of primary care researchers, in obtaining ethics approval to 
      conduct an international study investigating medical error in general practice in
      six countries. It describes the ethics review processes applied to exactly the
      same research protocol for a study run in Australia, Canada, England, the
      Netherlands, New Zealand, and the US. Wide variation in ethics review responses
      to the research proposal occurred, from no approval being deemed necessary to the
      study plan narrowly avoiding rejection. The authors' experiences demonstrated
      that ethics committees operate in their own historical and cultural context,
      which can lead to radically different subjective interpretations of commonly-held
      ethical principles, and raised further issues such as 'what is research?'. This
      first LINNAEUS study started when patient safety was a particularly sensitive
      subject. Although it is now a respectable area of inquiry, patient safety is
      still a topic that can excite emotions and prejudices. The LINNAEUS Collaboration
      now extends to more countries and continues to pursue an international research
      agenda, so reflection on the influences of history, social context, and structure
      of each country's ethical review processes is timely.
FAU - Dovey, Susan
AU  - Dovey S
AD  - Department of General Practice and Rural Health, Dunedin School of Medicine,
      University of Otago, Dunedin, New Zealand. susan.dovey@otago.ac.nz
FAU - Hall, Katherine
AU  - Hall K
FAU - Makeham, Meredith
AU  - Makeham M
FAU - Rosser, Walter
AU  - Rosser W
FAU - Kuzel, Anton
AU  - Kuzel A
FAU - Van Weel, Chris
AU  - Van Weel C
FAU - Esmail, Aneez
AU  - Esmail A
FAU - Phillips, Robert
AU  - Phillips R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Gen Pract
JT  - The British journal of general practice : the journal of the Royal College of
      General Practitioners
JID - 9005323
SB  - IM
MH  - Australia
MH  - Canada
MH  - *Ethical Review
MH  - *Ethics Committees
MH  - Europe
MH  - General Practice/*standards
MH  - Humans
MH  - Medical Errors/*prevention & control
MH  - New Zealand
MH  - *Research
MH  - Safety Management
MH  - United States
PMC - PMC3063049
EDAT- 2011/03/29 06:00
MHDA- 2011/05/28 06:00
CRDT- 2011/03/29 06:00
PHST- 2011/03/29 06:00 [entrez]
PHST- 2011/03/29 06:00 [pubmed]
PHST- 2011/05/28 06:00 [medline]
AID - 10.3399/bjgp11X567144 [doi]
PST - ppublish
SO  - Br J Gen Pract. 2011 Apr;61(585):197-204. doi: 10.3399/bjgp11X567144.


PMID- 21438938
OWN - NLM
STAT- MEDLINE
DCOM- 20110920
LR  - 20211020
IS  - 1360-0443 (Electronic)
IS  - 0965-2140 (Linking)
VI  - 106
IP  - 7
DP  - 2011 Jul
TI  - Randomized controlled trials in pregnancy: scientific and ethical aspects.
      Exposure to different opioid medications during pregnancy in an intra-individual 
      comparison.
PG  - 1355-62
LID - 10.1111/j.1360-0443.2011.03440.x [doi]
AB  - BACKGROUND: Chronic medical conditions such as opioid dependence require
      evidence-based treatment recommendations. However, pregnant women are
      under-represented in clinical trials. We describe the first within-subject
      comparison of maternal and neonatal outcomes for methadone- versus
      buprenorphine-exposed pregnancies. Although methadone is the established
      treatment of pregnant opioid-dependent women, recent investigations have shown a 
      trend for a milder neonatal abstinence syndrome (NAS) under buprenorphine.
      However, it is not only the choice of maintenance medication that determines the 
      occurrence of NAS; other factors such as maternal metabolism, illicit substance
      abuse and nicotine consumption also influence its severity and duration and
      represent confounding factors in the assessment of randomized clinical trials.
      CASE SERIES DESCRIPTION: Three women who were part of the European cohort of a
      randomized, double-blind multi-center trial with a contingency management tool
      [the Maternal Opioid Treatment: Human Experimental Research (MOTHER) study], each
      had two consecutive pregnancies and were maintained on either methadone or
      buprenorphine for their first and then the respective opposite, still-blinded
      medication for their second pregnancy. Birth measurements, the total neonatal
      abstinence score, the total amounts of medication used to treat NAS and the days 
      of NAS treatment duration were assessed. RESULTS: Both medications were effective
      and safe in reducing illicit opioid relapse and avoiding preterm labor. Methadone
      maintenance yielded to a significantly higher neonatal birth weight. Data
      patterns suggest that buprenorphine exposure was associated with lower neonatal
      abstinence syndrome (NAS) scores. Findings from this unique case series are
      consistent with earlier reports using between-group analyses. CONCLUSIONS:
      Buprenorphine has the potential to become an established treatment alternative to
      methadone for pregnant opioid-dependent women. Under special consideration of
      ethical boundaries, psychopharmacological treatment during pregnancy must be
      addressed as an integral part of clinical research projects in order to optimize 
      treatment for women and neonates.
CI  - (c) 2011 The Authors, Addiction (c) 2011 Society for the Study of Addiction.
FAU - Unger, Annemarie
AU  - Unger A
AD  - The Department of Psychiatry and Psychotherapy, Medical University of Vienna,
      Vienna, Austria.
FAU - Jagsch, Reinhold
AU  - Jagsch R
FAU - Jones, Hendree
AU  - Jones H
FAU - Arria, Amelia
AU  - Arria A
FAU - Leitich, Harald
AU  - Leitich H
FAU - Rohrmeister, Klaudia
AU  - Rohrmeister K
FAU - Aschauer, Constantin
AU  - Aschauer C
FAU - Winklbaur, Berndadette
AU  - Winklbaur B
FAU - Bawert, Andjela
AU  - Bawert A
FAU - Fischer, Gabriele
AU  - Fischer G
LA  - eng
GR  - R01 DA018417-03/DA/NIDA NIH HHS/United States
GR  - R01 DA015764/DA/NIDA NIH HHS/United States
GR  - R01 DA018417-04S1/DA/NIDA NIH HHS/United States
GR  - R01DA018417/DA/NIDA NIH HHS/United States
GR  - R01 DA018417/DA/NIDA NIH HHS/United States
GR  - R01 DA018417-05/DA/NIDA NIH HHS/United States
GR  - R01 DA018417-01/DA/NIDA NIH HHS/United States
GR  - R01 DA018417-02/DA/NIDA NIH HHS/United States
GR  - R01 DA018417-04/DA/NIDA NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
DEP - 20110512
PL  - England
TA  - Addiction
JT  - Addiction (Abingdon, England)
JID - 9304118
RN  - 0 (Analgesics, Opioid)
RN  - 40D3SCR4GZ (Buprenorphine)
RN  - UC6VBE7V1Z (Methadone)
SB  - IM
MH  - Adult
MH  - Analgesics, Opioid/*therapeutic use
MH  - Birth Weight/drug effects
MH  - Buprenorphine/*therapeutic use
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - Methadone/*therapeutic use
MH  - Neonatal Abstinence Syndrome/*epidemiology/etiology/prevention & control
MH  - Opiate Substitution Treatment/methods
MH  - Opioid-Related Disorders/complications/*drug therapy
MH  - Pregnancy
MH  - Pregnancy Complications/*drug therapy
MH  - Severity of Illness Index
MH  - Smoking/epidemiology
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC3107876
MID - NIHMS282888
EDAT- 2011/03/29 06:00
MHDA- 2011/09/21 06:00
CRDT- 2011/03/29 06:00
PHST- 2011/03/29 06:00 [entrez]
PHST- 2011/03/29 06:00 [pubmed]
PHST- 2011/09/21 06:00 [medline]
AID - 10.1111/j.1360-0443.2011.03440.x [doi]
PST - ppublish
SO  - Addiction. 2011 Jul;106(7):1355-62. doi: 10.1111/j.1360-0443.2011.03440.x. Epub
      2011 May 12.


PMID- 21438325
OWN - NLM
STAT- MEDLINE
DCOM- 20110411
LR  - 20110325
IS  - 1003-0034 (Print)
IS  - 1003-0034 (Linking)
VI  - 24
IP  - 2
DP  - 2011 Feb
TI  - [Effect of Panax Notoginseng Saponins on autograft tendon healing in bone tunnel:
      interface histological characteristics].
PG  - 132-6
AB  - OBJECTIVE: To investigate the effect of Panax Notoginseng Saponins (PNS) on
      tendon healing in bone tunnel. METHODS: The experiment was performed in the
      animal laboratory, Wangjing hospital from April to August, 2010. All the
      experiment procedures were accorded with the animal ethical requirements. Twenty 
      New Zealand rabbits were randomly divided into blank control group and PNS group 
      with 10 animals in each group. Anterior cruciate ligament reconstruction with toe
      extensor tendon was done in knee joints of rabbits by suspend fixation model. PNS
      was injected in bone tunnel of rabbits in PNS group, and nothing was given to
      blank group. Specimens were collected at 4 and 8 weeks after surgery. Sections
      were stained with HE stain to observe the changes of interface tissue between
      bone tunnel and tendon graft. Interface types were classified according to
      Yamakado method. RESULTS: At 4 weeks after surgery, the interface was filled with
      connective tissue in both group, while at 8 weeks, there was not obvious gap
      between bone and tendon graft in both groups under macrography. Under microscope,
      there were more fibroblast in the PNS group. There was larger new bone formation 
      area in PNS group. The classification on the Yamakado type was significantly
      different between two group (P < 0.05). CONCLUSION: PNS can enhance tendon-bone
      healing in bone tunnel, and promote the connection between tendon and bone. The
      study lacks quantitative analysis of those criteria, and the mechanics of the
      promotion of tendon-bone healing has not been totally clear.
FAU - Zhang, Lei
AU  - Zhang L
AD  - Department of Arthroscopy and Sports Medicine, Wangfing Hospital, China Academy
      of Chinese Medical Sciences, Beijing 100700, China.
FAU - Li, Zhi-yao
AU  - Li ZY
FAU - Sun, Jin
AU  - Sun J
FAU - Ma, Jia
AU  - Ma J
FAU - Zhang, Sheng
AU  - Zhang S
FAU - Liu, Jin-song
AU  - Liu JS
FAU - Zhu, Jia
AU  - Zhu J
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Gu Shang
JT  - Zhongguo gu shang = China journal of orthopaedics and traumatology
JID - 9815790
RN  - 0 (Saponins)
SB  - IM
MH  - Animals
MH  - Bone and Bones/*drug effects/pathology/*physiopathology
MH  - Cell Count
MH  - Cell Proliferation/drug effects
MH  - Cell Shape/drug effects
MH  - Fibroblasts/drug effects/pathology
MH  - Male
MH  - Neovascularization, Physiologic/drug effects
MH  - Panax notoginseng/*chemistry
MH  - Rabbits
MH  - Saponins/*pharmacology
MH  - Tendons/*drug effects/pathology/*physiopathology/transplantation
MH  - Transplantation, Autologous
MH  - Wound Healing/*drug effects
EDAT- 2011/03/29 06:00
MHDA- 2011/04/13 06:00
CRDT- 2011/03/29 06:00
PHST- 2011/03/29 06:00 [entrez]
PHST- 2011/03/29 06:00 [pubmed]
PHST- 2011/04/13 06:00 [medline]
PST - ppublish
SO  - Zhongguo Gu Shang. 2011 Feb;24(2):132-6.


PMID- 24059570
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130925
LR  - 20170214
IS  - 1971-4009 (Print)
IS  - 1971-4009 (Linking)
VI  - 24
IP  - 1
DP  - 2011 Mar 29
TI  - Clinical application of susceptibility weighted imaging: exploring from routine
      service.
PG  - 38-47
AB  - To evaluate the usefulness of susceptibility weighted imaging (SWI) in clinical
      brain MRI. Retrospective study was performed after approval from institution
      Ethical Committee. The brain MRIs with SWI were selected from data base of the
      radiology department. Only cases with no abnormality in extra-axial location were
      included into the study. Two neuroradiologists revealed the images without
      knowledge of patients' history and diagnosis. The SWI was first interpreted. Then
      conventional MRI (cMRI) was interpreted after finishing data collection from SWI.
      Clinical data and final diagnosis were collected from information given on
      requested forms and followed up imaging studies. Descriptive analysis was
      performed. From January 2007 to December 2009, 82 cases were satisfied the
      inclusion criteria. There were 40 males and 42 females with age 7-79 years old
      (means = 47.45). The final diagnosis were normal brain imaging 4 cases (4.9%),
      dementia/atypical Parkinson disease 2 cases (2.4%), cerebrovascular disease 24
      cases (29.3%), parenchymal brain tumors 35 cases (42.7%), infection 4 cases
      (4.9%), multiple sclerosis (MS) 6 cases (7.3%) and inconclusive diagnosis 7 cases
      (8.5%). The abnormalities found on SWI were related to cMRI in 67 cases (81.7%). 
      Three cases (3.7%) had lesions on SWI not demonstrated on cMRI. The information
      got from SWI added on cMRI for interpretation and diagnosis in 43 cases (52.4%). 
      SWI were shown more detectable microbleed and changing visualization of cortical 
      and transmedullary veins. Microvascular structure inside the mass was
      demonstrated on SWI in brain tumor group. The increased transmedullary veins on
      SWI helped to confirm the non-neoplastic lesions. In selected cases with
      suspected or diagnosis of vascular disease and tumor, SWI added more information 
      on cMRI especially microbleed and microvascular structure.
FAU - Chawalparit, O
AU  - Chawalparit O
AD  - Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol
      University; Bangkok, Thailand - oak_art@yahoo.com.
FAU - Tritrakarn, S-O
AU  - Tritrakarn SO
FAU - Charnchaowanish, P
AU  - Charnchaowanish P
FAU - Pornpunyawut, P
AU  - Pornpunyawut P
FAU - Chobaroom, S
AU  - Chobaroom S
LA  - eng
PT  - Journal Article
DEP - 20110405
PL  - United States
TA  - Neuroradiol J
JT  - The neuroradiology journal
JID - 101295103
EDAT- 2011/03/29 00:00
MHDA- 2011/03/29 00:01
CRDT- 2013/09/25 06:00
PHST- 2010/10/04 00:00 [received]
PHST- 2011/01/03 00:00 [accepted]
PHST- 2013/09/25 06:00 [entrez]
PHST- 2011/03/29 00:00 [pubmed]
PHST- 2011/03/29 00:01 [medline]
AID - NRJ.v24.i1.p38 [pii]
AID - 10.1177/197140091102400108 [doi]
PST - ppublish
SO  - Neuroradiol J. 2011 Mar 29;24(1):38-47. doi: 10.1177/197140091102400108. Epub
      2011 Apr 5.


PMID- 21438180
OWN - NLM
STAT- MEDLINE
DCOM- 20110412
LR  - 20190918
IS  - 1532-7361 (Electronic)
IS  - 0039-6060 (Linking)
VI  - 149
IP  - 3
DP  - 2011 Mar
TI  - All in the family: how close is too close? The ethics of treating loved ones.
PG  - 433-7
FAU - Kerrigan, Jimmy
AU  - Kerrigan J
AD  - Department of Internal Medicine, Washington University School of Medicine, St.
      Louis, MO 63131, USA.
FAU - Rovelstad, Susan
AU  - Rovelstad S
FAU - Kodner, Ira J
AU  - Kodner IJ
FAU - La Puma, John
AU  - La Puma J
FAU - Keune, Jason D
AU  - Keune JD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Surgery
JT  - Surgery
JID - 0417347
SB  - IM
MH  - Aged
MH  - Coronary Artery Bypass/*ethics
MH  - *Ethics, Medical
MH  - Family
MH  - Female
MH  - Humans
MH  - *Physician-Patient Relations
MH  - Practice Guidelines as Topic
EDAT- 2011/03/26 06:00
MHDA- 2011/04/13 06:00
CRDT- 2011/03/26 06:00
PHST- 2011/03/26 06:00 [entrez]
PHST- 2011/03/26 06:00 [pubmed]
PHST- 2011/04/13 06:00 [medline]
AID - S0039-6060(11)00012-2 [pii]
AID - 10.1016/j.surg.2011.01.001 [doi]
PST - ppublish
SO  - Surgery. 2011 Mar;149(3):433-7. doi: 10.1016/j.surg.2011.01.001.


PMID- 21438164
OWN - NLM
STAT- MEDLINE
DCOM- 20120306
LR  - 20160511
IS  - 1942-7611 (Electronic)
IS  - 1942-7603 (Linking)
VI  - 3
IP  - 4
DP  - 2011 Apr
TI  - Phosphatidylethanol in blood (B-PEth): a marker for alcohol use and abuse.
PG  - 195-200
LID - 10.1002/dta.278 [doi]
AB  - Phosphatidylethanol (PEth) represents a group of glycerophospholipid homologues
      where ethanol by phospholipase D has been bound at the position that normally
      contains an amino-alcohol. Since the formation of PEth is specifically dependent 
      on ethanol, the diagnostic specificity of PEth as an alcohol biomarker is
      theoretically 100%. The half-life of PEth in blood is approximately 4 days. The
      amount of alcohol consumed correlates to blood concentration of PEth and PEth has
      been shown to be a more sensitive indicator of alcohol consumption than
      traditional alcohol markers, such as CDT (carbohydrate-deficient transferrin),
      GGT (gamma-glutamyl transferase), and MCV (mean corpuscular volume) or a
      combination of these. Almost all clinical data so far available are based on a
      high performance liquid chromatography (HPLC) method with limited analytical
      sensitivity. With the advent of methods with considerably higher analytical
      sensitivity (e.g. mass spectrometric methods), clinical sensitivity will increase
      correspondingly. The possibility of determining very low concentrations of PEth
      by new sensitive analytical techniques may, however, have both ethical and legal 
      consequences that have to be considered.
CI  - Copyright (c) 2011 John Wiley & Sons, Ltd.
FAU - Isaksson, Anders
AU  - Isaksson A
AD  - Department of Laboratory Medicine, Lund University, Skane University Hospital,
      SE-221 85 Lund, Sweden. anders.isaksson@skane.se
FAU - Walther, Lisa
AU  - Walther L
FAU - Hansson, Therese
AU  - Hansson T
FAU - Andersson, Anders
AU  - Andersson A
FAU - Alling, Christer
AU  - Alling C
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20110325
PL  - England
TA  - Drug Test Anal
JT  - Drug testing and analysis
JID - 101483449
RN  - 0 (Biomarkers)
RN  - 0 (Glycerophospholipids)
RN  - 0 (phosphatidylethanol)
SB  - IM
MH  - Alcohol Drinking/blood
MH  - Alcoholism/*blood/*diagnosis
MH  - Biomarkers/blood
MH  - Female
MH  - Glycerophospholipids/*blood/chemistry
MH  - Humans
MH  - Male
MH  - Middle Aged
EDAT- 2011/03/26 06:00
MHDA- 2012/03/07 06:00
CRDT- 2011/03/26 06:00
PHST- 2010/12/03 00:00 [received]
PHST- 2011/01/20 00:00 [revised]
PHST- 2011/01/20 00:00 [accepted]
PHST- 2011/03/26 06:00 [entrez]
PHST- 2011/03/26 06:00 [pubmed]
PHST- 2012/03/07 06:00 [medline]
AID - 10.1002/dta.278 [doi]
PST - ppublish
SO  - Drug Test Anal. 2011 Apr;3(4):195-200. doi: 10.1002/dta.278. Epub 2011 Mar 25.


PMID- 21437749
OWN - NLM
STAT- MEDLINE
DCOM- 20120116
LR  - 20220316
IS  - 1554-3528 (Electronic)
IS  - 1554-351X (Linking)
VI  - 43
IP  - 3
DP  - 2011 Sep
TI  - The viability of crowdsourcing for survey research.
PG  - 800-13
LID - 10.3758/s13428-011-0081-0 [doi]
AB  - Online contract labor portals (i.e., crowdsourcing) have recently emerged as
      attractive alternatives to university participant pools for the purposes of
      collecting survey data for behavioral research. However, prior research has not
      provided a thorough examination of crowdsourced data for organizational
      psychology research. We found that, as compared with a traditional university
      participant pool, crowdsourcing respondents were older, were more ethnically
      diverse, and had more work experience. Additionally, the reliability of the data 
      from the crowdsourcing sample was as good as or better than the corresponding
      university sample. Moreover, measurement invariance generally held across these
      groups. We conclude that the use of these labor portals is an efficient and
      appropriate alternative to a university participant pool, despite small
      differences in personality and socially desirable responding across the samples. 
      The risks and advantages of crowdsourcing are outlined, and an overview of
      practical and ethical guidelines is provided.
FAU - Behrend, Tara S
AU  - Behrend TS
AD  - Organizational Sciences & Communication, George Washington University,
      Washington, DC, USA. behrend@gwu.edu
FAU - Sharek, David J
AU  - Sharek DJ
FAU - Meade, Adam W
AU  - Meade AW
FAU - Wiebe, Eric N
AU  - Wiebe EN
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Behav Res Methods
JT  - Behavior research methods
JID - 101244316
SB  - IM
MH  - Behavioral Research
MH  - Data Collection/*methods
MH  - Humans
MH  - *Patient Selection
MH  - Personality
MH  - *Research Design
MH  - *Research Subjects
EDAT- 2011/03/26 06:00
MHDA- 2012/01/17 06:00
CRDT- 2011/03/26 06:00
PHST- 2011/03/26 06:00 [entrez]
PHST- 2011/03/26 06:00 [pubmed]
PHST- 2012/01/17 06:00 [medline]
AID - 10.3758/s13428-011-0081-0 [doi]
PST - ppublish
SO  - Behav Res Methods. 2011 Sep;43(3):800-13. doi: 10.3758/s13428-011-0081-0.


PMID- 21437515
OWN - NLM
STAT- MEDLINE
DCOM- 20111109
LR  - 20190606
IS  - 1678-4170 (Electronic)
IS  - 0066-782X (Linking)
VI  - 96
IP  - 4
DP  - 2011 Apr
TI  - Cardiovascular profile in patients with obstructive sleep apnea.
PG  - 293-9
LID - S0066-782X2011005000030 [pii]
AB  - BACKGROUND: Obstructive Sleep Apnea (OSA) is a risk factor for several
      cardiovascular conditions including increased cardiovascular mortality. It is
      therefore essential to know the major cardiovascular effects of sleep-disordered 
      breathing during a clinical evaluation. OBJECTIVE: To analyze the cardiovascular 
      characteristics of patients with OSA. METHODS: Patients underwent baseline
      polysomnography and were consecutively selected from the database of the Sleep
      Institute between March 2007 and March 2009. All patients were instructed to
      attend the clinic for blood collection, physical examination, 12-lead
      electrocardiogram, spirometry, cardiopulmonary exercise testing on a treadmill
      and transthoracic echocardiography. The study was approved by the Research Ethics
      Committee and recorded at http://clinicaltrials.gov/ under number: NCT00768625.
      RESULTS: We analyzed 261 patients and 108 controls. The main characteristics of
      patients with OSA were: obesity, hypertension, low plasma levels of high density 
      lipoprotein (HDL) and increased left atrial diameter compared with controls (3.75
      +/- 0.42; 3.61 +/- 0.41, p = 0.001), respectively. These associated
      characteristics correspond to a 16.6 increase in the likelihood of OSA regardless
      of reporting any symptoms of this disorder, such as sleepiness or snoring.
      CONCLUSION: In the sample studied, the mostly found cardiovascular profile of
      patients with OSA was: obesity, hypertension, low plasma levels of HDL and left
      atrial diameter increased.
FAU - Cintra, Fatima Dumas
AU  - Cintra FD
AD  - Departamento de Psicobiologia, Universidade Federal de Sao Paulo, SP, Brazil.
      fatimacintra@cardiol.br
FAU - Tufik, Sergio
AU  - Tufik S
FAU - Paola, Angelo de
AU  - Paola Ad
FAU - Feres, Marcia C
AU  - Feres MC
FAU - Melo-Fujita, Luciane
AU  - Melo-Fujita L
FAU - Oliveira, Wercules
AU  - Oliveira W
FAU - Rizzi, Camila
AU  - Rizzi C
FAU - Poyares, Dalva
AU  - Poyares D
LA  - eng
LA  - por
LA  - spa
SI  - ClinicalTrials.gov/NCT00768625
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110318
PL  - Brazil
TA  - Arq Bras Cardiol
JT  - Arquivos brasileiros de cardiologia
JID - 0421031
SB  - IM
MH  - Adult
MH  - Blood Chemical Analysis
MH  - Cardiovascular System/*physiopathology
MH  - Case-Control Studies
MH  - Exercise Test
MH  - Humans
MH  - Hypertension/complications
MH  - Male
MH  - Middle Aged
MH  - Obesity/complications
MH  - Polysomnography
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Sleep Apnea, Obstructive/etiology/*physiopathology
MH  - Spirometry
MH  - Time Factors
EDAT- 2011/03/26 06:00
MHDA- 2011/11/10 06:00
CRDT- 2011/03/26 06:00
PHST- 2011/03/26 06:00 [entrez]
PHST- 2011/03/26 06:00 [pubmed]
PHST- 2011/11/10 06:00 [medline]
AID - S0066-782X2011005000030 [pii]
AID - 10.1590/s0066-782x2011005000030 [doi]
PST - ppublish
SO  - Arq Bras Cardiol. 2011 Apr;96(4):293-9. doi: 10.1590/s0066-782x2011005000030.
      Epub 2011 Mar 18.


PMID- 21437469
OWN - NLM
STAT- MEDLINE
DCOM- 20111020
LR  - 20211020
IS  - 1678-7765 (Electronic)
IS  - 1678-7757 (Linking)
VI  - 19
IP  - 1
DP  - 2011 Jan-Feb
TI  - Validation of an experimental polyurethane model for biomechanical studies on
      implant-supported prosthesis--compression tests.
PG  - 47-51
LID - S1678-77572011000100010 [pii]
AB  - OBJECTIVES: The complexity and heterogeneity of human bone, as well as ethical
      issues, most always hinder the performance of clinical trials. Thus, in vitro
      studies become an important source of information for the understanding of
      biomechanical events on implant-supported prostheses, although study results
      cannot be considered reliable unless validation studies are conducted. The
      purpose of this work was to validate an artificial experimental model based on
      its modulus of elasticity, to simulate the performance of human bone in vivo in
      biomechanical studies of implant-supported prostheses. MATERIAL AND METHODS: In
      this study, fast-curing polyurethane (F16 polyurethane, Axson) was used to build 
      40 specimens that were divided into five groups. The following reagent ratios
      (part A/part B) were used: Group A (0.5/1.0), Group B (0.8/1.0), Group C
      (1.0/1.0), Group D (1.2/1.0), and Group E (1.5/1.0). A universal testing machine 
      (Kratos model K - 2000 MP) was used to measure modulus of elasticity values by
      compression. RESULTS: Mean modulus of elasticity values were: Group A - 389.72
      MPa, Group B - 529.19 MPa, Group C - 571.11 MPa, Group D - 470.35 MPa, Group E - 
      437.36 MPa. CONCLUSION: The best mechanical characteristics and modulus of
      elasticity value comparable to that of human trabecular bone were obtained when
      A/B ratio was 1:1.
FAU - Moretti Neto, Rafael Tobias
AU  - Moretti Neto RT
AD  - Department of Clinics and Surgery, Dental School, Federal University of Alfenas, 
      Alfenas, MG, Brazil.
FAU - Hiramatsu, Daniel Afonso
AU  - Hiramatsu DA
FAU - Suedam, Valdey
AU  - Suedam V
FAU - Conti, Paulo Cesar Rodrigues
AU  - Conti PC
FAU - Rubo, Jose Henrique
AU  - Rubo JH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
PL  - Brazil
TA  - J Appl Oral Sci
JT  - Journal of applied oral science : revista FOB
JID - 101189774
RN  - 0 (Dental Implants)
RN  - 0 (Polyurethanes)
SB  - IM
MH  - Analysis of Variance
MH  - Biomechanical Phenomena
MH  - Compressive Strength
MH  - *Dental Implants
MH  - Dental Prosthesis Design/*methods
MH  - Dental Prosthesis, Implant-Supported/*methods
MH  - Elasticity
MH  - Materials Testing
MH  - Models, Theoretical
MH  - *Polyurethanes
PMC - PMC4245863
EDAT- 2011/03/26 06:00
MHDA- 2011/10/21 06:00
CRDT- 2011/03/26 06:00
PHST- 2009/05/19 00:00 [received]
PHST- 2010/04/27 00:00 [accepted]
PHST- 2011/03/26 06:00 [entrez]
PHST- 2011/03/26 06:00 [pubmed]
PHST- 2011/10/21 06:00 [medline]
AID - S1678-77572011000100010 [pii]
AID - 10.1590/s1678-77572011000100010 [doi]
PST - ppublish
SO  - J Appl Oral Sci. 2011 Jan-Feb;19(1):47-51. doi: 10.1590/s1678-77572011000100010.


PMID- 21437364
OWN - NLM
STAT- MEDLINE
DCOM- 20110722
LR  - 20191210
IS  - 1680-5348 (Electronic)
IS  - 1020-4989 (Linking)
VI  - 29
IP  - 2
DP  - 2011 Feb
TI  - [Drug advertising and promotion: regulations and extent of compliance in five
      Latin American countries].
PG  - 76-83
LID - S1020-49892011000200002 [pii]
AB  - OBJECTIVE: To analyze differing regulations regarding drug promotion, and the
      extent of compliance as seen in samples of advertising directed to the public in 
      Argentina, Colombia, Ecuador, Nicaragua, and Peru. METHODS: A total of 683 pieces
      of promotional material on display in health facilities, pharmacies, and on the
      street were collected, 132 of which were randomly selected for analysis. The
      regulations governing pharmaceutical advertising, taken from official websites
      and interviews with regulatory officials and Ministry of Health staff in the five
      countries covered, were reviewed, along with their adherence to the ethical
      criteria of the World Health Organization (WHO). The contents of the materials in
      the sample were evaluated to determine their degree of compliance with national
      regulations and WHO recommendations on drug promotion. RESULTS: The countries
      have regulations incorporating WHO ethical criteria. Over 80% of the material
      analyzed included the indications for the drug, while over 70% omitted
      information on adverse effects. Fifty percent of the advertisements for
      over-the-counter (OTC) drugs on display in pharmacies listed indications not
      approved by the relevant health authority. In advertising in pharmacies, the
      risks from inadequate information were not found to differ significantly for OTC 
      or prescription medications. Compared with materials provided in health
      facilities, the relative risk of the absence of information on dosage in the
      material distributed in pharmacies was 2.08 (confidence interval 95% 1.32-3.39). 
      CONCLUSIONS: Although regulations on drug promotion and advertising in the five
      countries studied generally incorporate the WHO recommendations, promotional
      materials often fail to reflect the fact.
FAU - Vacca, Claudia
AU  - Vacca C
AD  - Universidad Nacional de Colombia, Bogota, Colombia. cpvacag@bt.unal.edu.co
FAU - Vargas, Claudia
AU  - Vargas C
FAU - Canas, Martin
AU  - Canas M
FAU - Reveiz, Ludovic
AU  - Reveiz L
LA  - spa
PT  - Comparative Study
PT  - Journal Article
TT  - Publicidad y promocion de medicamentos: regulaciones y grado de acatamiento en
      cinco paises de America Latina.
PL  - United States
TA  - Rev Panam Salud Publica
JT  - Revista panamericana de salud publica = Pan American journal of public health
JID - 9705400
RN  - 0 (Nonprescription Drugs)
SB  - IM
MH  - Advertising/ethics/*legislation & jurisprudence/standards/statistics & numerical 
      data
MH  - Guideline Adherence
MH  - Health Facilities
MH  - Health Promotion
MH  - Internet
MH  - Latin America
MH  - *Legislation, Drug
MH  - Marketing/ethics/legislation & jurisprudence/standards/statistics & numerical
      data
MH  - Nonprescription Drugs
MH  - Persuasive Communication
MH  - Pharmacies
MH  - Sampling Studies
MH  - World Health Organization
EDAT- 2011/03/26 06:00
MHDA- 2011/07/23 06:00
CRDT- 2011/03/26 06:00
PHST- 2010/05/14 00:00 [received]
PHST- 2010/11/01 00:00 [accepted]
PHST- 2011/03/26 06:00 [entrez]
PHST- 2011/03/26 06:00 [pubmed]
PHST- 2011/07/23 06:00 [medline]
AID - S1020-49892011000200002 [pii]
AID - 10.1590/s1020-49892011000200002 [doi]
PST - ppublish
SO  - Rev Panam Salud Publica. 2011 Feb;29(2):76-83. doi:
      10.1590/s1020-49892011000200002.


PMID- 21436957
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1687-9856 (Electronic)
IS  - 1687-9848 (Linking)
VI  - 2011
DP  - 2011
TI  - Pediatric ethics guidelines for hereditary medullary thyroid cancer.
PG  - 847603
LID - 10.1155/2011/847603 [doi]
AB  - Hereditary medullary thyroid cancer is an aggressive cancer for which there is no
      standard effective systemic therapy, but which can be prevented through genetic
      screening and prophylactic thyroidectomy. Although this cancer accounts for
      roughly 17% of all pediatric thyroid cancers, a significant percentage of
      affected families do not "accept" screening, while many gene carriers delay or
      refuse prophylactic thyroid surgery for their children. Current genetic screening
      practices in medullary thyroid cancer are inadequate; more than 50% of index
      patients with hereditary medullary thyroid cancer present with a thyroid mass; up
      to 75% have distant metastasis. These proposed pediatric ethics guidelines focus 
      on two ethical issues that affect at-risk children: (1) how do we identify
      at-risk children whose RET-positive relative refuses to disclose that they carry 
      the mutation? (2) How do we protect RET-positive children whose parents refuse
      prophylactic thyroidectomy?
FAU - Rosenthal, M Sara
AU  - Rosenthal MS
AD  - Program for Bioethics, Department of Internal Medicine, University of Kentucky,
      Suite K522, 740 South Limestone Street, Lexington, KY 40536-0284, USA.
FAU - Diekema, Douglas S
AU  - Diekema DS
LA  - eng
PT  - Journal Article
DEP - 20110307
PL  - England
TA  - Int J Pediatr Endocrinol
JT  - International journal of pediatric endocrinology
JID - 101516111
PMC - PMC3198744
EDAT- 2011/03/26 06:00
MHDA- 2011/03/26 06:01
CRDT- 2011/03/26 06:00
PHST- 2010/11/10 00:00 [received]
PHST- 2011/01/12 00:00 [accepted]
PHST- 2011/03/26 06:00 [entrez]
PHST- 2011/03/26 06:00 [pubmed]
PHST- 2011/03/26 06:01 [medline]
AID - 10.1155/2011/847603 [doi]
PST - ppublish
SO  - Int J Pediatr Endocrinol. 2011;2011:847603. doi: 10.1155/2011/847603. Epub 2011
      Mar 7.


PMID- 21436781
OWN - NLM
STAT- MEDLINE
DCOM- 20110812
LR  - 20160210
IS  - 2329-0358 (Electronic)
IS  - 1425-9524 (Linking)
VI  - 16
IP  - 1
DP  - 2011 Jan-Mar
TI  - Chimerism in hand transplantation.
PG  - 83-9
AB  - Hand transplantation (HTx), a non-life saving reconstructive procedure,
      significantly improves the quality of life of upper limb amputees. However, HTx
      recipients need to take immunosuppressive drugs for the remainder of their lives 
      and, despite dramatic improvements in the safety of modern immunosuppressive
      protocols, these patients continue to suffer from adverse effects, a fact which
      raises ethical doubts regarding the legitimacy of HTx given its non-life saving
      nature. Furthermore, the effectiveness of immunosuppressive treatment in
      preventing chronic rejection remains unclear. In order to circumvent these
      important impediments, the ultimate goal of composite tissue allografting (CTA)
      needs to be the induction of donor-specific tolerance. A possible way of
      attaining this objective may be chimerism, the coexistence in the host organism
      of 2 populations of cells of both donor and recipient origin. Clinical
      experiments of solid-organ transplant recipients and CTA research in animal
      models provide promising perspectives for establishing chimerism with the use of 
      the facilitating cells and regulatory T-cells. This article reviews the available
      data on achieved chimerism in HTx and the relevant literature.
FAU - Szajerka, Tobiasz
AU  - Szajerka T
AD  - Subdepartment of Limb Replantation of St. Jadwiga of Silesia Hospital in
      Trzebnica, Trzebnica, Poland.
FAU - Klimczak, Aleksandra
AU  - Klimczak A
FAU - Jablecki, Jerzy
AU  - Jablecki J
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Ann Transplant
JT  - Annals of transplantation
JID - 9802544
SB  - IM
MH  - Animals
MH  - Bone Marrow Transplantation
MH  - Dendritic Cells/immunology/transplantation
MH  - *Hand Transplantation
MH  - Humans
MH  - Immune Tolerance
MH  - Models, Animal
MH  - T-Lymphocytes, Regulatory/immunology/transplantation
MH  - Tissue Donors
MH  - Transplantation Chimera/*immunology
MH  - Transplantation Conditioning
MH  - Transplantation, Homologous
EDAT- 2011/03/26 06:00
MHDA- 2011/08/13 06:00
CRDT- 2011/03/26 06:00
PHST- 2011/03/26 06:00 [entrez]
PHST- 2011/03/26 06:00 [pubmed]
PHST- 2011/08/13 06:00 [medline]
AID - 881645 [pii]
PST - ppublish
SO  - Ann Transplant. 2011 Jan-Mar;16(1):83-9.


PMID- 21436671
OWN - NLM
STAT- MEDLINE
DCOM- 20110819
LR  - 20191210
IS  - 1938-808X (Electronic)
IS  - 1040-2446 (Linking)
VI  - 86
IP  - 5
DP  - 2011 May
TI  - Developing personal values: trainees' attitudes toward strikes by health care
      providers.
PG  - 580-5
LID - 10.1097/ACM.0b013e318212b551 [doi]
AB  - Worldwide, health care providers use strikes and job actions to influence policy.
      For health care providers, especially physicians, strikes create an ethical
      tension between an obligation to care for current patients (e.g., to provide care
      and avoid abandonment) and an obligation to better care for future patients by
      seeking system improvements (e.g., improvements in safety, to access, and in the 
      composition and strength of the health care workforce). This tension is further
      intensified when the potential benefit of a strike involves professional
      self-interest and the potential risk involves patient harm or death. By
      definition, trainees are still forming their professional identities and values, 
      including their opinions on fair wages, health policy, employee benefits,
      professionalism, and strikes. In this article, the authors explore these ethical 
      tensions, beginning with a discussion of reactions to a potential 2005 nursing
      strike at the University of California, Davis, Medical Center. The authors then
      propose a conceptual model describing factors that may influence health care
      providers' decisions to strike (including personal ethics, personal agency, and
      strike-related context). In particular, the authors explore the relationship
      between training level and attitudes toward taking a job action, such as going on
      strike. Because trainees' attitudes toward strikes continue to evolve during
      training, the authors maintain that open discussion around the ethics of health
      care professionals' strikes and other methods of conflict resolution should be
      included in medical education to enhance professionalism and systems-based
      practice training. The authors include sample case vignettes to help initiate
      these important discussions.
CI  - Copyright (c) by the Association of American medical Colleges.
FAU - Li, Su-Ting T
AU  - Li ST
AD  - Department of Pediatrics, University of California, Davis, School of Medicine,
      Sacramento, California 95817, USA. suting.li@ucdmc.ucdavis.edu
FAU - Srinivasan, Malathi
AU  - Srinivasan M
FAU - Der-Martirosian, Claudia
AU  - Der-Martirosian C
FAU - Kravitz, Richard L
AU  - Kravitz RL
FAU - Wilkes, Michael S
AU  - Wilkes MS
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Acad Med
JT  - Academic medicine : journal of the Association of American Medical Colleges
JID - 8904605
SB  - IM
CIN - Acad Med. 2011 May;86(5):548-51. PMID: 21646971
MH  - Attitude of Health Personnel
MH  - California
MH  - Female
MH  - Health Care Reform
MH  - Health Personnel/ethics/*organization & administration
MH  - Health Policy/*trends
MH  - Humans
MH  - *Internship and Residency
MH  - Male
MH  - Outcome Assessment, Health Care
MH  - Personal Satisfaction
MH  - Social Change
MH  - Social Responsibility
MH  - *Social Values
MH  - Strikes, Employee/*ethics/organization & administration
EDAT- 2011/03/26 06:00
MHDA- 2011/08/20 06:00
CRDT- 2011/03/26 06:00
PHST- 2011/03/26 06:00 [entrez]
PHST- 2011/03/26 06:00 [pubmed]
PHST- 2011/08/20 06:00 [medline]
AID - 10.1097/ACM.0b013e318212b551 [doi]
PST - ppublish
SO  - Acad Med. 2011 May;86(5):580-5. doi: 10.1097/ACM.0b013e318212b551.


PMID- 21436173
OWN - NLM
STAT- MEDLINE
DCOM- 20150612
LR  - 20151119
IS  - 0885-0666 (Print)
IS  - 0885-0666 (Linking)
VI  - 26
IP  - 5
DP  - 2011 Sep-Oct
TI  - End-of-life care in ICU: a practical guide.
PG  - 295-303
LID - 10.1177/0885066610392697 [doi]
AB  - Proper critical care training and management rests on 3 pillars-evidence-based
      patient care, proficient procedural skills, and compassionate end-of-life (EOL)
      management. The purpose of this manuscript is to provide a practical guide to EOL
      management for all bedside practitioners. The manuscript outlines not all but
      some fundamentally important ethical concepts and provides helpful rules and
      steps on end-of-life management based on my own personal experience and practice.
      Moreover, nowhere in the rigorous training of critical care or hospitalist
      physicians do we teach the procedure for removal of life-sustaining measures.
      Like any other procedure in medicine, it requires preparation, implementation and
      conclusion, as well as supervision and repetition to become proficient.
      Therefore, at the conclusion of this paper, an attempt is made to correct this
      lack of training by providing such outline and a guide.
CI  - (c) SAGE Publications 2011.
FAU - Spinello, Irene M
AU  - Spinello IM
AD  - Kern Medical Center, Department of Medicine, Bakersfield, CA, USA.
      spinelloi@kernmedctr.com
CN  - Kern Medical Center, Department of Medicine, Bakersfield, CA, USA
LA  - eng
PT  - Journal Article
PT  - Practice Guideline
PT  - Review
DEP - 20110324
PL  - United States
TA  - J Intensive Care Med
JT  - Journal of intensive care medicine
JID - 8610344
SB  - IM
MH  - *Critical Care/ethics/methods
MH  - Humans
MH  - Medical Futility/ethics
MH  - Resuscitation Orders
MH  - Right to Die
MH  - *Terminal Care/ethics/methods/psychology
MH  - Withholding Treatment
OTO - NOTNLM
OT  - communication
OT  - death
OT  - end-of-life care
OT  - futility
OT  - resuscitation
OT  - withdrawing treatment
OT  - withholding treatment
EDAT- 2011/03/26 06:00
MHDA- 2015/06/13 06:00
CRDT- 2011/03/26 06:00
PHST- 2010/01/15 00:00 [received]
PHST- 2011/03/26 06:00 [entrez]
PHST- 2011/03/26 06:00 [pubmed]
PHST- 2015/06/13 06:00 [medline]
AID - 0885066610392697 [pii]
AID - 10.1177/0885066610392697 [doi]
PST - ppublish
SO  - J Intensive Care Med. 2011 Sep-Oct;26(5):295-303. doi: 10.1177/0885066610392697. 
      Epub 2011 Mar 24.


PMID- 21436089
OWN - NLM
STAT- MEDLINE
DCOM- 20110811
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 259
IP  - 3
DP  - 2011 Jun
TI  - Mammography with synchrotron radiation: first clinical experience with
      phase-detection technique.
PG  - 684-94
LID - 10.1148/radiol.11100745 [doi]
AB  - PURPOSE: To prospectively evaluate the diagnostic contribution of mammography
      with synchrotron radiation in patients with questionable or suspicious breast
      abnormalities identified at combined digital mammography (DM) and ultrasonography
      (US). MATERIALS AND METHODS: The ethics committee approved this prospective
      study, and written informed consent was obtained from all patients. Mammography
      with synchrotron radiation was performed with a phase-detection technique at a
      synchrotron radiation laboratory. Forty-nine women who met at least one of the
      inclusion criteria (palpable mass, focal asymmetry, architectural distortion, or 
      equivocal or suspicious mass at DM; none clarified at US) were enrolled.
      Forty-seven women (mean age, 57.8 years +/- 8.8 [standard deviation]; age range, 
      43-78 years) completed the study protocol, which involved biopsy or follow-up for
      1 year as the reference standard. Breast Imaging Reporting and Data System
      (BI-RADS) scores of 1-3 were considered to indicate a negative result, while
      scores 4-5 were considered to indicate a positive result. The visibility of
      breast abnormalities and the glandular parenchymal structure at DM and at
      mammography with synchrotron radiation was compared by using the Wilcoxon signed 
      rank test. RESULTS: In 29 of the 31 patients with a final diagnosis of benign
      entity, mammography with synchrotron radiation yielded BI-RADS scores of 1-3. In 
      13 of the remaining 16 patients with a final diagnosis of malignancy, mammography
      with synchrotron radiation yielded BI-RADS scores of 4-5. Therefore, a
      sensitivity of 81% (13 of 16 patients) and a specificity of 94% (29 of 31
      patients) were achieved with use of the described BI-RADS dichotomization system.
      CONCLUSION: These study results suggest that mammography with synchrotron
      radiation can be used to clarify cases of questionable or suspicious breast
      abnormalities identified at DM. SUPPLEMENTAL MATERIAL:
      http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.11100745/-/DC1.
CI  - RSNA, 2011
FAU - Castelli, Edoardo
AU  - Castelli E
AD  - Department of Physics, University of Trieste, Via A. Valerio 2, 34127 Trieste,
      Italy. castelli@ts.infn.it
FAU - Tonutti, Maura
AU  - Tonutti M
FAU - Arfelli, Fulvia
AU  - Arfelli F
FAU - Longo, Renata
AU  - Longo R
FAU - Quaia, Emilio
AU  - Quaia E
FAU - Rigon, Luigi
AU  - Rigon L
FAU - Sanabor, Daniela
AU  - Sanabor D
FAU - Zanconati, Fabrizio
AU  - Zanconati F
FAU - Dreossi, Diego
AU  - Dreossi D
FAU - Abrami, Alessando
AU  - Abrami A
FAU - Quai, Elisa
AU  - Quai E
FAU - Bregant, Paola
AU  - Bregant P
FAU - Casarin, Katia
AU  - Casarin K
FAU - Chenda, Valentina
AU  - Chenda V
FAU - Menk, Ralf Hendrik
AU  - Menk RH
FAU - Rokvic, Tatjana
AU  - Rokvic T
FAU - Vascotto, Alessandro
AU  - Vascotto A
FAU - Tromba, Giuliana
AU  - Tromba G
FAU - Cova, Maria Assunta
AU  - Cova MA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110324
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biopsy
MH  - Breast Neoplasms/*diagnostic imaging
MH  - Female
MH  - Humans
MH  - Mammography/*methods
MH  - Middle Aged
MH  - Prospective Studies
MH  - Radiation Dosage
MH  - Sensitivity and Specificity
MH  - Statistics, Nonparametric
MH  - *Synchrotrons
EDAT- 2011/03/26 06:00
MHDA- 2011/08/13 06:00
CRDT- 2011/03/26 06:00
PHST- 2011/03/26 06:00 [entrez]
PHST- 2011/03/26 06:00 [pubmed]
PHST- 2011/08/13 06:00 [medline]
AID - radiol.11100745 [pii]
AID - 10.1148/radiol.11100745 [doi]
PST - ppublish
SO  - Radiology. 2011 Jun;259(3):684-94. doi: 10.1148/radiol.11100745. Epub 2011 Mar
      24.


PMID- 21436087
OWN - NLM
STAT- MEDLINE
DCOM- 20110811
LR  - 20220318
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 259
IP  - 3
DP  - 2011 Jun
TI  - T1rho MR imaging is sensitive to evaluate liver fibrosis: an experimental study
      in a rat biliary duct ligation model.
PG  - 712-9
LID - 10.1148/radiol.11101638 [doi]
AB  - PURPOSE: To correlate spin-lattice relaxation time in the rotating frame (T1rho) 
      measurements with degree of liver fibrosis in a rat model. MATERIALS AND METHODS:
      The protocols and procedures were approved by the local Animal Experimentation
      Ethics Committee. Liver fibrosis was induced with biliary duct ligation (BDL).
      Two studies, 1 month apart, were performed with a 3-T clinical imager. The first 
      study involved longitudinal magnetic resonance (MR) imaging follow-up of BDL rats
      (n = 8) and control rats (n = 4) on days 8, 15, 21, and 29 after BDL. The second 
      study involved MR imaging of another group of BDL and control rats (n = 5 for
      each) on days 24 and 38 after BDL. Hematoxylin-eosin and picrosirius red staining
      were performed in liver specimens from days 8, 15, 24, and 38 after BDL.
      Repeated-measures analysis of variance was used, and treatment groups were
      compared (Bonferroni adjustment). RESULTS: On day 8, there were proliferation of 
      bile duct and inflammatory cell infiltration around portal triads. While there
      was overlap, BDL rats (n = 8) demonstrated higher mean liver T1rho values than
      did control rats (n = 4) on day 8 (46.7 msec +/- 2.9 [standard deviation] vs 44.7
      msec +/- 1.2, P = .4). On day 15, BDL rats demonstrated liver fibrosis with a
      background of inflammatory infiltration. On day 15, mean T1rho values in BDL rats
      could be largely separated from those in control rats (52.6 msec +/- 6.0 vs 43.8 
      msec +/- 1.5, P = .02). On day 24, BDL rats had liver T1rho values 23.5% higher
      than in control rats (n = 5 for each group, P = .0007). Histomorphometric
      analysis showed that collagen content increased after surgery from days 8 to 24
      (n = 6 for each group, P < .0001), with no further increase between days 24 and
      38 (n = 6 for each group, P >.99). CONCLUSION: In this model, liver fibrosis was 
      detected with T1rho MR imaging; the degree of fibrosis was correlated with degree
      of increase in T1rho measurements. SUPPLEMENTAL MATERIAL:
      http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.11101638/-/DC1.
CI  - RSNA, 2011
FAU - Wang, Yi-Xiang J
AU  - Wang YX
AD  - Department of Imaging and Interventional Radiology, Prince of Wales Hospital, the
      Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.
      yixiang_wang@cuhk.edu.hk
FAU - Yuan, Jing
AU  - Yuan J
FAU - Chu, Eagle S H
AU  - Chu ES
FAU - Go, Minnie Y Y
AU  - Go MY
FAU - Huang, Hua
AU  - Huang H
FAU - Ahuja, Anil T
AU  - Ahuja AT
FAU - Sung, Joseph J Y
AU  - Sung JJ
FAU - Yu, Jun
AU  - Yu J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110324
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
CIN - Radiology. 2011 Jun;259(3):619-20. PMID: 21602499
MH  - Analysis of Variance
MH  - Animals
MH  - Bile Ducts/surgery
MH  - Disease Models, Animal
MH  - Ligation
MH  - Linear Models
MH  - Liver Cirrhosis/*pathology
MH  - Magnetic Resonance Imaging/*methods
MH  - Rats
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
EDAT- 2011/03/26 06:00
MHDA- 2011/08/13 06:00
CRDT- 2011/03/26 06:00
PHST- 2011/03/26 06:00 [entrez]
PHST- 2011/03/26 06:00 [pubmed]
PHST- 2011/08/13 06:00 [medline]
AID - radiol.11101638 [pii]
AID - 10.1148/radiol.11101638 [doi]
PST - ppublish
SO  - Radiology. 2011 Jun;259(3):712-9. doi: 10.1148/radiol.11101638. Epub 2011 Mar 24.


PMID- 21435934
OWN - NLM
STAT- MEDLINE
DCOM- 20110810
LR  - 20151119
IS  - 1769-6682 (Electronic)
IS  - 1297-9589 (Linking)
VI  - 39
IP  - 4
DP  - 2011 Apr
TI  - [Decision-making in termination of pregnancy: a French perspective].
PG  - 198-204
LID - 10.1016/j.gyobfe.2011.02.002 [doi]
AB  - OBJECTIVE: To evaluate the caregivers' opinions regarding decision-making in
      termination of pregnancy (TOP) for fetal anomaly. MATERIAL AND METHODS:
      Questionnaire survey using a semi-structured survey based on visual analogue
      scales, sent to all multidisciplinary centres for prenatal diagnosis in France.
      Answers were received from 26 centres nation-wide. RESULTS: Response rate was 39%
      (213 responses received over 550 questionnaires sent). Fifty-five percent of
      respondents were women, 90% physicians, 7,5% midwives. A vast majority (69.8%)
      believes that their own convictions play a bigger role in decision in real
      practice than in their ideal. The major decisional factors in decision-making for
      TOP are: the long-term prognosis of the anomaly, a specialized opinion on its
      curability, the quality of the information given to the future parents, their
      expressed opinion, the existence of a multidisciplinary decision, the ability of 
      the future parents to understand the medical data, the obtention of a medical
      consensus, the proof level of the medical information. For only 55% of the
      respondents, the current legal framework is adequate to manage the situations
      that result from prenatal diagnostic practices today. The question of late
      third-trimester TOP raises ethical debate: over a third (37%) see no ethical
      difference between TOP and withdrawal of care during the neonatal period; the
      majority (48% versus 43%) feel that ethically speaking a neonate and a foetus at 
      39 weeks gestational age (GA) should not be treated differently; 37% of the
      respondents feel that current practice is likely to lead to eugenism. DISCUSSION 
      AND CONCLUSION: As far as TOP is concerned, the huge discrepancies in responses
      from the professionals highlight the ongoing ethical debate, especially
      concerning the concept of informed choice in TOP, which we believe should be
      entirely revisited.
CI  - Copyright (c) 2011 Elsevier Masson SAS. All rights reserved.
FAU - Gorincour, G
AU  - Gorincour G
AD  - Espace ethique Mediterraneen, EA 3783, universite de la Mediterranee, hopital de 
      La Timone, Marseille, France. guillaume.gorincour@ap-hm.fr
FAU - Tassy, S
AU  - Tassy S
FAU - Payot, A
AU  - Payot A
FAU - Philip, N
AU  - Philip N
FAU - Malzac, P
AU  - Malzac P
FAU - Harle, J-R
AU  - Harle JR
FAU - Mattei, J-F
AU  - Mattei JF
FAU - Le Coz, P
AU  - Le Coz P
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Decision d'interruption medicale de grossesse : le point de vue des soignants
      francais.
DEP - 20110323
PL  - France
TA  - Gynecol Obstet Fertil
JT  - Gynecologie, obstetrique & fertilite
JID - 100936305
SB  - IM
MH  - Abortion, Induced/*psychology
MH  - Attitude of Health Personnel
MH  - Congenital Abnormalities/*psychology
MH  - *Decision Making
MH  - Female
MH  - France
MH  - Health Surveys
MH  - Humans
MH  - Male
MH  - Parents/psychology
MH  - Pregnancy
MH  - Prenatal Diagnosis/psychology
MH  - Surveys and Questionnaires
EDAT- 2011/03/26 06:00
MHDA- 2011/08/11 06:00
CRDT- 2011/03/26 06:00
PHST- 2010/10/29 00:00 [received]
PHST- 2011/02/01 00:00 [accepted]
PHST- 2011/03/26 06:00 [entrez]
PHST- 2011/03/26 06:00 [pubmed]
PHST- 2011/08/11 06:00 [medline]
AID - S1297-9589(11)00040-3 [pii]
AID - 10.1016/j.gyobfe.2011.02.002 [doi]
PST - ppublish
SO  - Gynecol Obstet Fertil. 2011 Apr;39(4):198-204. doi: 10.1016/j.gyobfe.2011.02.002.
      Epub 2011 Mar 23.


PMID- 21435814
OWN - NLM
STAT- MEDLINE
DCOM- 20120628
LR  - 20120416
IS  - 0736-4679 (Print)
IS  - 0736-4679 (Linking)
VI  - 42
IP  - 4
DP  - 2012 Apr
TI  - Pseudoaneurysm in the hand of a three-year-old boy: a case report.
PG  - e87-9
LID - 10.1016/j.jemermed.2010.11.049 [doi]
AB  - BACKGROUND: Post-traumatic, true aneurysm of the hand is a well-documented
      phenomenon. Hypothenar hammer syndrome is often a consequence of repeated blunt
      trauma to the palm, but a false aneurysm, or pseudoaneurysm, of the palm is much 
      rarer. A pseudoaneurysm is often the result of focal penetrating trauma.
      OBJECTIVES: The goal of this article is to describe a rare case of a child with a
      pseudoaneurysm of the superficial palmar arch and his subsequent surgical
      treatment. CASE REPORT: A 3-year-old boy sustained an accidental laceration to
      his palm while picking up a knife from a counter. The child was initially treated
      in a local Emergency Department (ED) with local wound care and Dermabond
      (Ethicon, Inc., Somerville, NJ). No imaging was undertaken at that time. The boy 
      subsequently developed a large, pulsatile, painful mass in his palm near the site
      of injury, and he presented to our ED for evaluation. Using a combination of
      imaging modalities and a careful history, the boy was accurately diagnosed with a
      pseudoaneurysm of the superficial palmar arch. This lesion was subsequently
      successfully resected and repaired. The child has healed well after surgery, with
      no lasting sensory or motor deficits to the hand. To date, this is one of only
      two reported post-traumatic pseudoaneurysms of the palmar arch in a child in
      North America. CONCLUSION: Although a rare phenomenon, pseudoaneurysm of the
      superficial palmar arch after local penetrating trauma remains an important item 
      on the differential for patients presenting with palmar masses. Pseudoaneurysm
      can be effectively diagnosed and treated with excellent results.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Hughes, Christopher D
AU  - Hughes CD
AD  - Integrated General Surgery Residency, University of Connecticut, Farmington, CT
      06119, USA.
FAU - Binette, Christopher
AU  - Binette C
FAU - Babigian, Alan
AU  - Babigian A
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20110323
PL  - United States
TA  - J Emerg Med
JT  - The Journal of emergency medicine
JID - 8412174
SB  - IM
MH  - Aneurysm, False/*etiology
MH  - Child, Preschool
MH  - Hand Injuries/*complications
MH  - Humans
MH  - Male
MH  - *Radial Artery
MH  - Wounds, Penetrating/*complications
EDAT- 2011/03/26 06:00
MHDA- 2012/06/29 06:00
CRDT- 2011/03/26 06:00
PHST- 2010/04/23 00:00 [received]
PHST- 2010/07/14 00:00 [revised]
PHST- 2010/11/09 00:00 [accepted]
PHST- 2011/03/26 06:00 [entrez]
PHST- 2011/03/26 06:00 [pubmed]
PHST- 2012/06/29 06:00 [medline]
AID - S0736-4679(11)00200-9 [pii]
AID - 10.1016/j.jemermed.2010.11.049 [doi]
PST - ppublish
SO  - J Emerg Med. 2012 Apr;42(4):e87-9. doi: 10.1016/j.jemermed.2010.11.049. Epub 2011
      Mar 23.


PMID- 21435805
OWN - NLM
STAT- MEDLINE
DCOM- 20111028
LR  - 20110418
IS  - 1873-4111 (Electronic)
IS  - 0378-5122 (Linking)
VI  - 69
IP  - 1
DP  - 2011 May
TI  - The ethics of IVF over 40.
PG  - 37-40
LID - 10.1016/j.maturitas.2011.02.012 [doi]
AB  - The average age of women having their first child has been rising in recent
      decades [1]. Since fertility declines with age, it is not surprising that larger 
      numbers of women over 40 are seeking IVF. Any change in reproductive norms tends 
      to generate concern. Women's apparent postponement of motherhood has met with
      criticism directed variously at women themselves, and at society for its failure 
      to support women to have children at the 'appropriate' time. The provision of IVF
      to women over 40 is one facet of this broader social trend towards later
      reproduction.In this paper I consider a number of ethical problems that might be 
      connected with the provision of IVF to patients over 40. I look at risks to women
      and offspring, and also consider questions of efficacy and cost-effectiveness. I 
      discuss the possibility that IVF for older women could raise increase the
      problems associated with egg procurement. Finally I address the concept of
      medicalisation and suggest that as long as IVF is regarded as a medical
      treatment, access to it should not be used as a means of social control. Nor
      should it be provided or withheld on the basis of moral judgements about
      patients' values or lifestyles.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Smajdor, Anna
AU  - Smajdor A
AD  - School of Medicine, Health Policy and Practice, University of East Anglia,
      Norwich, UK. acsmajdor@gmail.com
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110323
PL  - Ireland
TA  - Maturitas
JT  - Maturitas
JID - 7807333
SB  - IM
MH  - Adult
MH  - Aging/physiology
MH  - Female
MH  - Fertilization in Vitro/*ethics
MH  - Humans
MH  - Infertility, Female
MH  - Maternal Age
MH  - Middle Aged
MH  - Refusal to Treat/*ethics
MH  - Reproduction/*ethics
EDAT- 2011/03/26 06:00
MHDA- 2011/10/29 06:00
CRDT- 2011/03/26 06:00
PHST- 2011/02/10 00:00 [received]
PHST- 2011/02/14 00:00 [accepted]
PHST- 2011/03/26 06:00 [entrez]
PHST- 2011/03/26 06:00 [pubmed]
PHST- 2011/10/29 06:00 [medline]
AID - S0378-5122(11)00047-8 [pii]
AID - 10.1016/j.maturitas.2011.02.012 [doi]
PST - ppublish
SO  - Maturitas. 2011 May;69(1):37-40. doi: 10.1016/j.maturitas.2011.02.012. Epub 2011 
      Mar 23.


PMID- 21435766
OWN - NLM
STAT- MEDLINE
DCOM- 20120522
LR  - 20161125
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 74
IP  - 1
DP  - 2012 Jan
TI  - Cross-border mobility of health professionals: contesting patients' right to
      health.
PG  - 20-7
LID - 10.1016/j.socscimed.2011.02.012 [doi]
AB  - Cross-border labour mobility in the health sector is portrayed as both an
      opportunity for health professionals immigrating to developed countries, and as a
      challenge for patients remaining in low-income countries with restricted access
      to health care provision. In policy debate, this problem is articulated as the
      opposition between, 'the right to freedom of movement' and 'the right to health'.
      The underlying layers of this dilemma expose competing institutional interests
      for source and destination countries, international organisations, private
      recruitment agencies, trade unions and professional organisations. To resolve
      some of these tensions, a 'soft law' regulation (ethical recruitment policy) was 
      adopted in the UK in the early 2000s. This article argues that this ethical
      recruitment policy produces an ambivalent effect. The qualitative content
      analysis refers to documents produced by international organisations, government 
      bodies, professional organisations and trade unions in the UK and source
      countries. We found that ethical recruitment on the one hand proposes a practical
      mechanism to the realisation of the right to health in source countries, through 
      encouraging employers' behaviour in accordance with ethical principles in
      international recruitment. On the other hand, this policy protects the reputation
      of institutional stakeholders changing rhetoric around international recruitment 
      rather than the practice. The findings of this study contribute to a broader
      discussion of the international norms diffusion and the ambivalent role of 'soft 
      law' in their implementation.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Plotnikova, Evgeniya Vadimovna
AU  - Plotnikova EV
AD  - Social and Political Studies, University of Edinburgh, George Square 15A,
      Chrystal Macmillan Building, Edinburgh EH8 9LD, United Kingdom.
      E.Plotnikova@sms.ed.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20110303
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - *Emigration and Immigration/legislation & jurisprudence
MH  - *Health Personnel
MH  - Health Services Accessibility
MH  - Humans
MH  - *Patient Rights
MH  - Personnel Selection/*ethics
MH  - Public Policy
MH  - United Kingdom
EDAT- 2011/03/26 06:00
MHDA- 2012/05/23 06:00
CRDT- 2011/03/26 06:00
PHST- 2010/01/31 00:00 [received]
PHST- 2011/01/31 00:00 [revised]
PHST- 2011/02/08 00:00 [accepted]
PHST- 2011/03/26 06:00 [entrez]
PHST- 2011/03/26 06:00 [pubmed]
PHST- 2012/05/23 06:00 [medline]
AID - S0277-9536(11)00098-0 [pii]
AID - 10.1016/j.socscimed.2011.02.012 [doi]
PST - ppublish
SO  - Soc Sci Med. 2012 Jan;74(1):20-7. doi: 10.1016/j.socscimed.2011.02.012. Epub 2011
      Mar 3.


PMID- 21435303
OWN - NLM
STAT- MEDLINE
DCOM- 20110531
LR  - 20141120
IS  - 1469-2147 (Electronic)
IS  - 0963-1801 (Linking)
VI  - 20
IP  - 2
DP  - 2011 Apr
TI  - Access to life-saving medicines and intellectual property rights: an ethical
      assessment.
PG  - 279-89
LID - 10.1017/S0963180110000939 [doi]
FAU - Schroeder, Doris
AU  - Schroeder D
AD  - Centre for Professional Ethics, University of Central Lancashire, Preston, UK.
FAU - Singer, Peter
AU  - Singer P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Camb Q Healthc Ethics
JT  - Cambridge quarterly of healthcare ethics : CQ : the international journal of
      healthcare ethics committees
JID - 9208482
SB  - IM
MH  - Developing Countries
MH  - *Drug Industry/ethics/legislation & jurisprudence
MH  - Ethical Analysis
MH  - Ethical Theory
MH  - Global Health
MH  - Health Services Accessibility/*ethics
MH  - Humans
MH  - *Intellectual Property
MH  - *Legislation, Drug/ethics/standards/trends
MH  - *Neglected Diseases/drug therapy
MH  - Patents as Topic/legislation & jurisprudence
MH  - *Patient Rights/ethics/legislation & jurisprudence/trends
MH  - *Social Justice
MH  - Social Responsibility
EDAT- 2011/03/26 06:00
MHDA- 2011/06/01 06:00
CRDT- 2011/03/26 06:00
PHST- 2011/03/26 06:00 [entrez]
PHST- 2011/03/26 06:00 [pubmed]
PHST- 2011/06/01 06:00 [medline]
AID - S0963180110000939 [pii]
AID - 10.1017/S0963180110000939 [doi]
PST - ppublish
SO  - Camb Q Healthc Ethics. 2011 Apr;20(2):279-89. doi: 10.1017/S0963180110000939.


PMID- 21435295
OWN - NLM
STAT- MEDLINE
DCOM- 20110531
LR  - 20191210
IS  - 1469-2147 (Electronic)
IS  - 0963-1801 (Linking)
VI  - 20
IP  - 2
DP  - 2011 Apr
TI  - The challenge of nonconfrontational ethics.
PG  - 204-15
LID - 10.1017/S096318011000085X [doi]
FAU - Harris, John
AU  - Harris J
AD  - The Institute for Science, Ethics and Innovation, School of Law, University of
      Manchester, United Kingdom.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Camb Q Healthc Ethics
JT  - Cambridge quarterly of healthcare ethics : CQ : the international journal of
      healthcare ethics committees
JID - 9208482
SB  - IM
MH  - Abortion, Induced/ethics
MH  - Bioethics/*trends
MH  - *Biomedical Enhancement/ethics
MH  - Conflict, Psychological
MH  - *Ethical Theory
MH  - Homicide
MH  - Humans
MH  - *Interprofessional Relations
MH  - Personhood
MH  - Problem Solving
MH  - *Quality of Life
MH  - Social Justice
MH  - *Value of Life
EDAT- 2011/03/26 06:00
MHDA- 2011/06/01 06:00
CRDT- 2011/03/26 06:00
PHST- 2011/03/26 06:00 [entrez]
PHST- 2011/03/26 06:00 [pubmed]
PHST- 2011/06/01 06:00 [medline]
AID - S096318011000085X [pii]
AID - 10.1017/S096318011000085X [doi]
PST - ppublish
SO  - Camb Q Healthc Ethics. 2011 Apr;20(2):204-15. doi: 10.1017/S096318011000085X.


PMID- 21435197
OWN - NLM
STAT- MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1471-2296 (Electronic)
IS  - 1471-2296 (Linking)
VI  - 12
DP  - 2011 Mar 24
TI  - The use of pure and impure placebo interventions in primary care - a qualitative 
      approach.
PG  - 11
LID - 10.1186/1471-2296-12-11 [doi]
AB  - BACKGROUND: Placebos play an important role in clinical trials and several
      surveys have shown that they are also common in daily practice. Previous research
      focused primarily on the frequency of placebo use in outpatient care. Our aim was
      to explore physicians' views on the use of placebos in daily practice, whereby
      distinction was made between pure placebos (substances with no pharmacological
      effect, e.g. sugar pills) and impure placebos (substances with pharmacological
      effect but not on the condition being treated, e.g. antibiotics in viral
      infections or vitamins). METHODS: We performed semi-structured interviews with a 
      sample of twelve primary care physicians (PCPs). The interview addressed
      individual definitions of a placebo, attitudes towards placebos and the
      participants' reasons for prescribing them. The interviews were transcribed and
      analysed using qualitative content analysis. RESULTS: The definition of a placebo
      given by the majority of the PCPs in our study was one which actually only
      describes pure placebos. This definition, combined with the fact that most impure
      placebos were not regarded as placebos at all, means that most of the
      participating PCPs were not aware of the extent to which placebos are used in
      daily practice. The PCPs stated that they use placebos (both pure and impure)
      mainly in the case of non-severe diseases for which there was often no
      satisfactory somatic explanation. According to the PCPs, cases like this are
      often treated by complementary and alternative therapies and these, too, are
      associated with placebo effects. However, all PCPs felt that the ethical aspects 
      of such treatment were unclear and they were unsure as to how to communicate the 
      use of placebos to their patients. Most of them would appreciate ethical
      guidelines on how to deal with this issue. CONCLUSIONS: Many PCPs seem to be
      unaware that some of the drugs they prescribe are classified as impure placebos. 
      Perceptions of effectiveness and doubts about the legal and ethical aspects of
      the use of placebos by PCPs may discourage their application. Dissemination of
      guidelines and consensus papers may be one approach, but it has to be
      acknowledged that the topic itself is in conflict with the PCPs' perception of
      themselves as professional and reliable physicians.
FAU - Fent, Rahel
AU  - Fent R
AD  - Institute of General Practice and Health Services Research, University of Zurich,
      Pestalozzistrasse 24, 8091 Zurich, Switzerland.
FAU - Rosemann, Thomas
AU  - Rosemann T
FAU - Fassler, Margrit
AU  - Fassler M
FAU - Senn, Oliver
AU  - Senn O
FAU - Huber, Carola A
AU  - Huber CA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110324
PL  - England
TA  - BMC Fam Pract
JT  - BMC family practice
JID - 100967792
RN  - 0 (Placebos)
SB  - IM
MH  - Aged
MH  - *Attitude of Health Personnel
MH  - Evaluation Studies as Topic
MH  - Female
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Middle Aged
MH  - Physicians, Family/*psychology
MH  - Placebo Effect
MH  - Placebos/*administration & dosage
MH  - Practice Patterns, Physicians'
MH  - Primary Health Care
PMC - PMC3068943
EDAT- 2011/03/26 06:00
MHDA- 2011/07/16 06:00
CRDT- 2011/03/26 06:00
PHST- 2010/09/14 00:00 [received]
PHST- 2011/03/24 00:00 [accepted]
PHST- 2011/03/26 06:00 [entrez]
PHST- 2011/03/26 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
AID - 1471-2296-12-11 [pii]
AID - 10.1186/1471-2296-12-11 [doi]
PST - epublish
SO  - BMC Fam Pract. 2011 Mar 24;12:11. doi: 10.1186/1471-2296-12-11.


PMID- 21435153
OWN - NLM
STAT- MEDLINE
DCOM- 20111123
LR  - 20151119
IS  - 1464-410X (Electronic)
IS  - 1464-4096 (Linking)
VI  - 108
IP  - 8 Pt 2
DP  - 2011 Oct
TI  - A pilot study of endorectal magnetic resonance imaging and magnetic resonance
      spectroscopic imaging changes with dutasteride in patients with low risk prostate
      cancer.
PG  - E164-70
LID - 10.1111/j.1464-410X.2010.10061.x [doi]
AB  - OBJECTIVE: *To evaluate the effects of dutasteride on treatment-naive prostate
      cancer in men using serial magnetic resonance imaging (MRI) and magnetic
      resonance spectroscopic imaging (MRSI) in this pilot study. PATIENTS AND METHODS:
      *This investigator-initiated prospective single-arm study was approved by the
      institutional committee on human research ethics board. *The target accrual was
      10 patients. Newly diagnosed prostate cancer patients with low risk disease
      either with symptomatic benign prostatic hypertrophy or deemed to require
      pre-brachytherapy androgen suppression therapy were eligible. In the latter
      group, dutasteride was used to achieve cytoreduction. *All patients received 6
      months of dutasteride 3.5 mg daily and underwent baseline blood work,
      health-related quality of life indices and MRI/MRSI, which were repeated at 1, 3 
      and 6 months. *MRSI spectra were examined and scored as healthy or cancerous. The
      change in cancerous volumes over time was evaluated. RESULTS: *Of the 10 patients
      enrolled, nine patients completed the entire study. One patient withdrew after 3 
      months because of drug-related toxicity. *Because a significant decrease in
      citrate and polyamines on MRSI spectra was noted at 1 month compared with
      baseline, healthy tissue appeared to be more like cancer and thus created a false
      impression that the cancer had grown after 1 month. To reduce this bias,
      comparisons were made between the 1-month and 6-month scans. *The median MR
      cancer volumes at 6 months and 3 months were 100% and 101% of the 1-month value, 
      respectively. Three of the nine patients had a 30-45% decrease in cancer volume
      at 6 months relative to 1-month measures. Of the others, two had no change in
      cancer volume and four had an increase (range 65-167% of the 1-month value). *The
      median cancer volume (range) at baseline was only 0.5 (0.1-5.6) mL. CONCLUSIONS: 
      *The inclusion of only men with low volume disease may have limited our ability
      to accurately assess response rates after dutasteride due to the background
      effects on normal prostate metabolism. Despite this, one-third of patients had a 
      30-45% reduction in cancer volume at 6 months. *Future studies including men with
      larger volume disease may enable estimates of response rates to be made more
      accurately.
CI  - (c) 2011 THE AUTHORS. BJU INTERNATIONAL (c) 2011 BJU INTERNATIONAL.
FAU - Chung, Hans T
AU  - Chung HT
AD  - Department of Radiation Oncology, Odette Cancer Centre, University of Toronto,
      Canada. hans.chung@sunnybrook.ca
FAU - Noworolski, Susan M
AU  - Noworolski SM
FAU - Kurhanewicz, John
AU  - Kurhanewicz J
FAU - Weinberg, Vivian
AU  - Weinberg V
FAU - Roach Iii, Mack
AU  - Roach Iii M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110324
PL  - England
TA  - BJU Int
JT  - BJU international
JID - 100886721
RN  - 0 (5-alpha Reductase Inhibitors)
RN  - 0 (Azasteroids)
RN  - O0J6XJN02I (Dutasteride)
SB  - IM
MH  - 5-alpha Reductase Inhibitors/*therapeutic use
MH  - Adenocarcinoma/*diagnosis/*drug therapy
MH  - Aged
MH  - Azasteroids/*therapeutic use
MH  - Dutasteride
MH  - Humans
MH  - *Magnetic Resonance Imaging/methods
MH  - *Magnetic Resonance Spectroscopy
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - Prospective Studies
MH  - Prostatic Neoplasms/*diagnosis/*drug therapy
MH  - Rectum
EDAT- 2011/03/26 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/03/26 06:00
PHST- 2011/03/26 06:00 [entrez]
PHST- 2011/03/26 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1111/j.1464-410X.2010.10061.x [doi]
PST - ppublish
SO  - BJU Int. 2011 Oct;108(8 Pt 2):E164-70. doi: 10.1111/j.1464-410X.2010.10061.x.
      Epub 2011 Mar 24.


PMID- 21434750
OWN - NLM
STAT- MEDLINE
DCOM- 20110722
LR  - 20191210
IS  - 1943-2852 (Electronic)
IS  - 1546-0371 (Linking)
VI  - 39
IP  - 1
DP  - 2011 Spring
TI  - The family doctor: psychodynamic psychotherapy in tightly knit communities.
PG  - 169-77
LID - 10.1521/jaap.2011.39.1.169 [doi]
AB  - Although unusual, psychodynamic psychiatrists engage in the practice of treating 
      multiple members, and constellations of members, of families with psychodynamic
      psychotherapy as well as other treatment modalities. Such clinicians are
      considered the "Family Psychiatrist." Psychological characteristics of such
      families who cannot be referred to other clinicians are articulated. The
      literature on psychotherapy in small rural communities is reviewed as having
      relevance to define the ethical issues that arise in such treatments. These
      issues include: maintaining therapeutic neutrality; creating functional,
      flexible, and appropriate boundaries; maintaining confidentiality; promoting
      patient autonomy and growth; as well as managing conflicts of interest. Relevant 
      countertransference issues are examined.
FAU - Katz-Bearnot, Sherry
AU  - Katz-Bearnot S
AD  - Columbia University College of Physicians and Surgeons, Department of Psychiatry,
      New York, New York 10023, USA. spk1@columbia.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Acad Psychoanal Dyn Psychiatry
JT  - The journal of the American Academy of Psychoanalysis and Dynamic Psychiatry
JID - 101177980
SB  - IM
MH  - Communication
MH  - Confidentiality
MH  - Countertransference
MH  - Family/*psychology
MH  - Humans
MH  - Personal Autonomy
MH  - *Professional-Family Relations
MH  - Psychoanalytic Therapy/*ethics
MH  - Rural Health Services
MH  - United States
EDAT- 2011/03/26 06:00
MHDA- 2011/07/23 06:00
CRDT- 2011/03/26 06:00
PHST- 2011/03/26 06:00 [entrez]
PHST- 2011/03/26 06:00 [pubmed]
PHST- 2011/07/23 06:00 [medline]
AID - 10.1521/jaap.2011.39.1.169 [doi]
AID - 10.1521/jaap.2011.39.1.169 [pii]
PST - ppublish
SO  - J Am Acad Psychoanal Dyn Psychiatry. 2011 Spring;39(1):169-77. doi:
      10.1521/jaap.2011.39.1.169.


PMID- 21434486
OWN - NLM
STAT- MEDLINE
DCOM- 20110407
LR  - 20220408
IS  - 1128-3602 (Print)
IS  - 1128-3602 (Linking)
VI  - 15
IP  - 2
DP  - 2011 Feb
TI  - [Congenital toxoplasmosis treatment]
PG  - 193-8
AB  - OBJECTIVES: Congenital toxoplasmosis is a particular manifestation of Toxoplasma 
      gondii infection, which may present as a mild or severe neonatal disease. This
      pathology remains a difficult challenge in terms of therapy for the pediatrician 
      and gynecologist. In this article we have set ourselves the objective to provide 
      an overview of the main aspects of the disease, with particular attention to the 
      treatment, based on the information in the literature. RESULTS: Two kinds of
      treatment are currently available: prenatal and postnatal. When pregnant women
      seroconvert, spiramycin is administered in order to prevent the mother-to-child
      transmission. When the fetal infection is confirmed the association of
      pyrimethamine and sulfadiazine is prescribed. After birth the specific therapy is
      based on the administration of pyrimethamine and sulfadiazine. However, to date, 
      there is not strong evidence on the effectiveness of treatment, whether prenatal 
      or postnatal. CONCLUSIONS: The studies undertaken so far have not given
      satisfactory answers. Double-blind randomized controlled trials would be
      required, but for obvious ethical reasons they cannot be achieved.
FAU - Serranti, D
AU  - Serranti D
AD  - Department of Pediatrics, Catholic University of the Sacred Heart, Rome, Italy.
FAU - Buonsenso, D
AU  - Buonsenso D
FAU - Valentini, P
AU  - Valentini P
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - Eur Rev Med Pharmacol Sci
JT  - European review for medical and pharmacological sciences
JID - 9717360
SB  - IM
MH  - Female
MH  - Guidelines as Topic
MH  - Humans
MH  - Infant, Newborn
MH  - Pregnancy
MH  - Pregnancy Complications, Parasitic/drug therapy
MH  - Toxoplasma/*drug effects
MH  - Toxoplasmosis, Congenital/diagnosis/*drug therapy/epidemiology
EDAT- 2011/03/26 06:00
MHDA- 2011/04/08 06:00
CRDT- 2011/03/26 06:00
PHST- 2011/03/26 06:00 [entrez]
PHST- 2011/03/26 06:00 [pubmed]
PHST- 2011/04/08 06:00 [medline]
PST - ppublish
SO  - Eur Rev Med Pharmacol Sci. 2011 Feb;15(2):193-8.


PMID- 21432713
OWN - NLM
STAT- MEDLINE
DCOM- 20110509
LR  - 20120329
IS  - 1528-7394 (Print)
IS  - 0098-4108 (Linking)
VI  - 74
IP  - 10
DP  - 2011
TI  - Alternative bioassay for the detection of saxitoxin using the speckled cockroach 
      (Nauphoeta cinerea).
PG  - 621-37
LID - 10.1080/15287394.2011.534426 [doi]
AB  - Paralytic shellfish poisoning (PSP) toxins produced by cyanobacteria pose a risk 
      to public health as they occur in drinking water reservoirs and recreational
      lakes and accumulate in the food chain. One of these PSP toxins, saxitoxin (STX) 
      is one of the most toxic nonprotein substances known. Accordingly, there is a
      requirement to monitor for these toxins. The standard bioassay used to detect
      these toxins is the mouse bioassay; however, its use is constrained by animal
      ethics guidelines and practical considerations. Reported here is the use of the
      globally distributed speckled cockroach Nauphoeta cinerea as a bioassay test
      organism for the selective detection of PSP toxicity of Anabaena circinalis
      aqueous extract and STX. N. cinerea was shown to be tolerant to pure
      cylindrospermopsin (CYN) and microcystin-LR (MC-LR) at doses 10-fold greater than
      mouse LD(5)(0) values while being sensitive to STX. Similarly, N. cinerea was
      shown to be tolerant of toxin-containing aqueous extracts of Cylindrospermopsis
      raciborskii, Microcystis aeruginosa, and Nodularia spumigena while being
      sensitive to A. circinalis. Peak sensitivity to STX was 60 min postinjection with
      a KD(5)(0) of 31.2 ng/g body weight. While this was approximately 3-fold less
      sensitive than the mouse bioassay, the insect test organism was around 34-fold
      smaller in mass than a mouse (20 g); thus one-tenth the amount of toxin in
      absolute quantity was required to reach an ED(5)(0) level. The N. cinerea
      bioassay presents a selective test for PSP toxicity that is rapid, economical,
      efficient, and simple to perform.
FAU - Ruebhart, David R
AU  - Ruebhart DR
AD  - HydroTox Services Australia Pty Ltd, Croydon, Victoria 3136, Australia.
      david_ruebhart@hydrotox.com.au
FAU - Radcliffe, Wendy L
AU  - Radcliffe WL
FAU - Eaglesham, Geoffrey K
AU  - Eaglesham GK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Toxicol Environ Health A
JT  - Journal of toxicology and environmental health. Part A
JID - 100960995
RN  - 0 (Poisons)
RN  - 35523-89-8 (Saxitoxin)
RN  - 7786-34-7 (Mevinphos)
SB  - IM
MH  - Anabaena
MH  - Animals
MH  - Biological Assay/*methods
MH  - Cockroaches/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - Environmental Monitoring/methods
MH  - Mevinphos/toxicity
MH  - Nervous System/drug effects
MH  - Poisons/isolation & purification/*toxicity
MH  - Saxitoxin/isolation & purification/*toxicity
MH  - Shellfish Poisoning/prevention & control
EDAT- 2011/03/25 06:00
MHDA- 2011/05/10 06:00
CRDT- 2011/03/25 06:00
PHST- 2011/03/25 06:00 [entrez]
PHST- 2011/03/25 06:00 [pubmed]
PHST- 2011/05/10 06:00 [medline]
AID - 935263378 [pii]
AID - 10.1080/15287394.2011.534426 [doi]
PST - ppublish
SO  - J Toxicol Environ Health A. 2011;74(10):621-37. doi:
      10.1080/15287394.2011.534426.


PMID- 21431935
OWN - NLM
STAT- MEDLINE
DCOM- 20120313
LR  - 20211020
IS  - 2210-7711 (Electronic)
VI  - 33
IP  - 3
DP  - 2011 Jun
TI  - Generic and therapeutic substitution: ethics meets health economics.
PG  - 469-70
LID - 10.1007/s11096-011-9500-7 [doi]
FAU - Simoens, Steven
AU  - Simoens S
LA  - eng
PT  - Letter
DEP - 20110324
PL  - Netherlands
TA  - Int J Clin Pharm
JT  - International journal of clinical pharmacy
JID - 101554912
RN  - 0 (Drugs, Generic)
SB  - IM
CIN - Int J Clin Pharm. 2011 Dec;33(6):881. PMID: 21927801
MH  - Drug Substitution/*economics/*ethics
MH  - Drugs, Generic/*economics
MH  - Health Care Costs/*ethics
MH  - Humans
EDAT- 2011/03/25 06:00
MHDA- 2012/03/14 06:00
CRDT- 2011/03/25 06:00
PHST- 2011/02/21 00:00 [received]
PHST- 2011/02/24 00:00 [accepted]
PHST- 2011/03/25 06:00 [entrez]
PHST- 2011/03/25 06:00 [pubmed]
PHST- 2012/03/14 06:00 [medline]
AID - 10.1007/s11096-011-9500-7 [doi]
PST - ppublish
SO  - Int J Clin Pharm. 2011 Jun;33(3):469-70. doi: 10.1007/s11096-011-9500-7. Epub
      2011 Mar 24.


PMID- 21431529
OWN - NLM
STAT- MEDLINE
DCOM- 20110701
LR  - 20181201
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Linking)
VI  - 698
DP  - 2011
TI  - Hepatic transplantation of mesenchymal stem cells in rodent animal models.
PG  - 315-30
LID - 10.1007/978-1-60761-999-4_24 [doi]
AB  - The hepatocyte is the smallest functional entity of the liver and executes the
      majority of this organ's -metabolic functions. Hence, hepatocyte transplantation 
      has become a versatile alternative to whole organ liver transplantation. This
      novel treatment option is based on the assumption that transplanted -hepatocytes 
      integrate into the host liver, proliferate at the site of tissue damage, take
      over the long-term hepatic -synthetic capacity, and thus substitute for the
      diseased host tissue. However, clinical success is still waiting for a
      breakthrough, likely because of two major reasons including (1) the scarcity of
      cadaveric donor livers and (2) the largely poor quality of cells isolated from
      marginal quality donor organs. Therefore, alternative cell sources have to be
      established to further prompt the clinical success of hepatocyte transplantation.
      Due to their multiple differentiation potential and nearly unlimited
      availability, stem cells are an attractive -alternate resource. Because of both
      clinical and ethical objections, adult stem cells are often preferred over
      embryonic stem cells as a starting material. Recent studies have demonstrated the
      ability of mesenchymal stem cells derived from various tissues to differentiate
      into hepatocyte-like cells in vitro as well as showing specific hepatocyte
      functions in vivo after transplantation into the livers of mice or rats.
FAU - Christ, Bruno
AU  - Christ B
AD  - First Department of Medicine, Martin-Luther University of Halle-Wittenberg,
      Halle/Saale, Germany. bruno.christ@medizin.uni-halle.de
FAU - Bruckner, Sandra
AU  - Bruckner S
FAU - Stock, Peggy
AU  - Stock P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
RN  - EC 3.4.14.5 (Dipeptidyl Peptidase 4)
SB  - IM
MH  - Adipose Tissue/cytology
MH  - Animals
MH  - Bone Marrow Cells/cytology
MH  - Cell Separation
MH  - Dipeptidyl Peptidase 4/metabolism
MH  - Flow Cytometry
MH  - Gene Expression Regulation
MH  - Humans
MH  - Immunohistochemistry
MH  - Liver/*cytology
MH  - Mesenchymal Stem Cell Transplantation/*methods
MH  - Mesenchymal Stem Cells/metabolism
MH  - Mice
MH  - Models, Animal
MH  - Perfusion
MH  - Portal Vein
MH  - Rats
MH  - Spleen/metabolism
EDAT- 2011/03/25 06:00
MHDA- 2011/07/02 06:00
CRDT- 2011/03/25 06:00
PHST- 2011/03/25 06:00 [entrez]
PHST- 2011/03/25 06:00 [pubmed]
PHST- 2011/07/02 06:00 [medline]
AID - 10.1007/978-1-60761-999-4_24 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2011;698:315-30. doi: 10.1007/978-1-60761-999-4_24.


PMID- 21431286
OWN - NLM
STAT- MEDLINE
DCOM- 20120316
LR  - 20211020
IS  - 2629-3277 (Electronic)
IS  - 2629-3277 (Linking)
VI  - 7
IP  - 4
DP  - 2011 Nov
TI  - Umbilical cord lining stem cells as a novel and promising source for ocular
      surface regeneration.
PG  - 935-47
LID - 10.1007/s12015-011-9245-7 [doi]
AB  - The stem cells involved in renewal of the corneal epithelium are located in the
      basal region of the limbus, a narrow transition zone surrounding the cornea. In
      many ocular surface disorders loss of these stem cells results in partial or
      complete vision loss. Conventional corneal transplant in these patients is
      associated with dismal results. Stem cell transplantation offers new hope to such
      patients. The umbilical cord is emerging as an important source of stem cells
      that may have potential clinical applications. There are advantages to the use of
      umbilical cord stem cells as these cells are less immunogenic, non-tumorigenic,
      highly proliferative and ethically acceptable. In this study, we have confirmed
      the expression of several putative limbal stem cell markers such as HES1, ABCG2, 
      BMI1, CK15 as well as cell adhesion-associated molecules INTEGRIN-alpha6,
      -alpha9, -beta1, COLLAGEN-IV and LAMININ in our recently characterized CLEC-muc
      population derived from human umbilical cord. Ex vivo expansion of these cells on
      a human amniotic membrane substrate formed a stratified cell sheet that similarly
      expresses some of these molecules as well as cornea-specific cytokeratins, CK3
      and CK12. Transplantation of a bioengineered CLEC-muc sheet in limbal stem
      cell-deficient rabbit eyes resulted in regeneration of a smooth, clear corneal
      surface with phenotypic expression of the normal corneal-specific epithelial
      markers CK3, CK12 but not CK4 or CK1/10. Our results suggest that CLEC-muc is a
      novel stem cell that can be ex vivo expanded for corneal epithelial regeneration 
      in the treatment of various eye diseases.
FAU - Reza, Hasan Mahmud
AU  - Reza HM
AD  - Singapore Eye Research Institute, Singapore, Singapore.
FAU - Ng, Boon-Yee
AU  - Ng BY
FAU - Gimeno, Federico Luengo
AU  - Gimeno FL
FAU - Phan, Toan Thang
AU  - Phan TT
FAU - Ang, Leonard Pek-Kiang
AU  - Ang LP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Stem Cell Rev Rep
JT  - Stem cell reviews and reports
JID - 101752767
RN  - 0 (Biomarkers)
RN  - 0 (Cell Adhesion Molecules)
SB  - IM
MH  - Amnion/metabolism
MH  - Animals
MH  - Biomarkers/analysis/metabolism
MH  - Cell Adhesion Molecules/metabolism
MH  - Cells, Cultured
MH  - Corneal Diseases/metabolism/*therapy
MH  - Epithelium, Corneal/injuries/metabolism/transplantation
MH  - Gene Expression Regulation
MH  - Humans
MH  - Immunohistochemistry
MH  - Limbus Corneae/injuries/metabolism
MH  - Models, Animal
MH  - Phenotype
MH  - Rabbits
MH  - *Regeneration
MH  - Stem Cell Transplantation
MH  - Stem Cells/*cytology/metabolism
MH  - Tissue Engineering/methods
MH  - Transplantation, Heterologous
MH  - Umbilical Cord/*cytology
EDAT- 2011/03/25 06:00
MHDA- 2012/03/17 06:00
CRDT- 2011/03/25 06:00
PHST- 2011/03/25 06:00 [entrez]
PHST- 2011/03/25 06:00 [pubmed]
PHST- 2012/03/17 06:00 [medline]
AID - 10.1007/s12015-011-9245-7 [doi]
PST - ppublish
SO  - Stem Cell Rev Rep. 2011 Nov;7(4):935-47. doi: 10.1007/s12015-011-9245-7.


PMID- 21431084
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1559-3258 (Electronic)
IS  - 1559-3258 (Linking)
VI  - 9
IP  - 1
DP  - 2011 Feb 22
TI  - Human Health and the Biological Effects of Tritium in Drinking Water: Prudent
      Policy Through Science - Addressing the ODWAC New Recommendation.
PG  - 6-31
LID - 10.2203/dose-response.10-048.Boreham [doi]
AB  - Tritium is a radioactive form of hydrogen and is a by-product of energy
      production in Canadian Deuterium Uranium (CANDU) reactors. The release of this
      radioisotope into the environment is carefully managed at CANDU facilities in
      order to minimize radiation exposure to the public. However, under some
      circumstances, small accidental releases to the environment can occur. The
      radiation doses to humans and non-human biota from these releases are low and
      orders of magnitude less than doses received from naturally occurring
      radioisotopes or from manmade activities, such as medical imaging and air travel.
      There is however a renewed interest in the biological consequences of low dose
      tritium exposures and a new limit for tritium levels in Ontario drinking water
      has been proposed. The Ontario Drinking Water Advisory Council (ODWAC) issued a
      formal report in May 2009 in response to a request by the Minister of the
      Environment, concluding that the Ontario Drinking Water Quality Standard for
      tritium should be revised from the current 7,000 Bq/L level to a new, lower 20
      Bq/L level. In response to this recommendation, an international scientific
      symposium was held at McMaster University to address the issues surrounding this 
      change in direction and the validity of a new policy. Scientists, regulators,
      government officials, and industrial stakeholders were present to discuss the
      potential health risks associated with low level radiation exposure from tritium.
      The regulatory, economic, and social implications of the new proposed limit were 
      also considered.The new recommendation assumed a linear-no-threshold model to
      calculate carcinogenic risk associated with tritium exposure, and considered
      tritium as a non-threshold chemical carcinogen. Both of these assumptions are
      highly controversial given that recent research suggests that low dose exposures 
      have thresholds below which there are no observable detrimental effects.
      Furthermore, mutagenic and carcinogenic risk calculated from tritium exposure at 
      20 Bq/L would be orders of magnitude less than that from exposure to natural
      background sources of radiation. The new proposed standard would set the
      radiation dose limit for drinking water to 0.0003 mSv/year, which is equivalent
      to approximately three times the dose from naturally occurring tritium in
      drinking water. This new standard is incongruent with national and international 
      standards for safe levels of radiation exposure, currently set at 1 mSv/year for 
      the general public. Scientific research from leading authorities on the
      carcinogenic health effects of tritium exposure supports the notion that the
      current standard of 7,000 Bq/L (annual dose of 0.1 mSv) is a safe standard for
      human health.Policy-making for the purpose of regulating tritium levels in
      drinking water is a dynamic multi-stage process that is influenced by more than
      science alone. Ethics, economics, and public perception also play important roles
      in policy development; however, these factors sometimes undermine the scientific 
      evidence that should form the basis of informed decision making. Consequently,
      implementing a new standard without a scientific basis may lead the public to
      perceive that risks from tritium have been historically underestimated. It was
      concluded that the new recommendation is not supported by any new scientific
      insight regarding negative consequences of low dose effects, and may be contrary 
      to new data on the potential benefits of low dose effects. Given the lack of cost
      versus benefit analysis, this type of dramatic policy change could have
      detrimental effects to society from an ethical, economical, and public perception
      perspective.
FAU - Dingwall, S
AU  - Dingwall S
AD  - Department of Medical Physics and Applied Radiation Sciences, McMaster
      University, Hamilton, ON, CAN, L8S 4K1.
FAU - Mills, C E
AU  - Mills CE
FAU - Phan, N
AU  - Phan N
FAU - Taylor, K
AU  - Taylor K
FAU - Boreham, D R
AU  - Boreham DR
LA  - eng
PT  - Journal Article
DEP - 20110222
PL  - United States
TA  - Dose Response
JT  - Dose-response : a publication of International Hormesis Society
JID - 101308899
PMC - PMC3057633
OTO - NOTNLM
OT  - Carcinogen
OT  - Health Risk
OT  - Low Dose Radiation
OT  - Standard
OT  - Tritium
EDAT- 2011/03/25 06:00
MHDA- 2011/03/25 06:01
CRDT- 2011/03/25 06:00
PHST- 2011/03/25 06:00 [entrez]
PHST- 2011/03/25 06:00 [pubmed]
PHST- 2011/03/25 06:01 [medline]
AID - 10.2203/dose-response.10-048.Boreham [doi]
PST - epublish
SO  - Dose Response. 2011 Feb 22;9(1):6-31. doi: 10.2203/dose-response.10-048.Boreham.


PMID- 21431014
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1998-3794 (Electronic)
IS  - 0019-5545 (Linking)
VI  - 53
IP  - 1
DP  - 2011 Jan
TI  - Placeboxetine for major depressive disorder: Researcher, author, reader, and
      reviewer perspectives on randomized controlled trials.
PG  - 73-6
LID - 10.4103/0019-5545.75553 [doi]
AB  - BACKGROUND: Postgraduate students, budding authors, clinicians who read journals,
      and new reviewers need to develop skills in reading, writing, and reviewing
      papers that describe randomized controlled trials (RCTs). MATERIALS AND METHODS: 
      This commentary critically examines a specially-written paper (published in the
      same issue of this journal) that describes a fictitious, industry-driven,
      multicentre RCT comparing the fictitious antidepressant placeboxetine with
      sertraline in Indian patients with major depressive disorder. Readers are invited
      to independently assess the RCT paper before they continue with this commentary. 
      RESULTS: Scientific aspects of the design and execution of the RCT are examined
      in the context of ethical issues in research. Comments and suggestions are
      offered on issues such as the statistical handling of data, manuscript content,
      and manuscript writing style. The reader's attention is drawn to subtle and
      not-so-subtle errors, as well as to curiosities in the data. CONCLUSIONS: It is
      hoped that this practical commentary on research design, execution, analysis, and
      reporting, based on specific examples, will benefit researchers, authors,
      readers, and reviewers more than guidance delivered in the form of general
      advice.
FAU - Andrade, Chittaranjan
AU  - Andrade C
AD  - Department of Psychopharmacology, National Institute of Mental Health and
      Neurosciences, Bangalore, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Psychiatry
JT  - Indian journal of psychiatry
JID - 0013255
PMC - PMC3056194
OTO - NOTNLM
OT  - Authors
OT  - major depressive disorder
OT  - placeboxetine
OT  - randomized controlled trial
OT  - reviewers
OT  - surviving peer review
OT  - writing skills
EDAT- 2011/03/25 06:00
MHDA- 2011/03/25 06:01
CRDT- 2011/03/25 06:00
PHST- 2011/03/25 06:00 [entrez]
PHST- 2011/03/25 06:00 [pubmed]
PHST- 2011/03/25 06:01 [medline]
AID - 10.4103/0019-5545.75553 [doi]
PST - ppublish
SO  - Indian J Psychiatry. 2011 Jan;53(1):73-6. doi: 10.4103/0019-5545.75553.


PMID- 21431011
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1998-3794 (Electronic)
IS  - 0019-5545 (Linking)
VI  - 53
IP  - 1
DP  - 2011 Jan
TI  - "Attenuated psychotic symptoms syndrome" as a risk syndrome of psychosis,
      diagnosis in DSM-V: The debate.
PG  - 57-65
LID - 10.4103/0019-5545.75560 [doi]
AB  - Schizophrenia is a common disorder, affecting approximately 1 out of every 100
      people, with a typical onset during adolescence and early adulthood. The personal
      and societal costs of schizophrenia are extremely high. Prevention of
      schizophrenia, would offer substantial benefits to patients, their family
      members, and the community at large. The prodromal phase of schizophrenia has
      been recognized since the 19th century. At-risk individuals for psychosis and
      schizophrenia are the subjects who can provide information for intervention prior
      to development of frank psychosis. This approach is currently being investigated.
      The question remains, however, whether it can be a diagnostic category by itself.
      The proposal for including the risk syndrome is one of the recommendations by the
      working group on schizophrenia and psychotic disorders for the forthcoming DSM-V.
      There are differing views in academia regarding this proposal. Prior to becoming 
      fully psychotic, a consistent literature demonstrates that patients generally had
      suffered from accelerating attenuated symptoms and distress. It is important that
      the prodromal phase be accurately recognized in order to accomplish the goal of
      prevention. We can then purposefully engage in early intervention aiming toward
      prevention. A recent strong resurgent interest in this area stems largely from
      two developments: First, the identification of the neurobiological deficit
      processes associated with the severity and chronicity of schizophrenia, and
      second, the development of reliable criteria for diagnosis. Although the general 
      at-risk construct appears to offer great potential to advance both the treatment 
      and research dealing with psychotic illnesses, it seems premature to many
      researchers to include the syndrome as an established entity in the text of the
      new DSM-V. It would be far more appropriate to include this proposed syndrome in 
      the appendix and evaluate the many contemporary issues in future studies. The
      main issues involved in this discussion are the clinical validity of the
      syndrome, concern about stigma and unnecessary treatment, and need for responding
      to patients' distress in addition to the ethical dilemma. In this review we
      examine the issue of inclusion of the risk syndrome as a diagnosis.
FAU - Shrivastava, Amresh
AU  - Shrivastava A
AD  - Department of Psychiatry, The University of Western Ontario, London and Physician
      Lead, Elgin-Prevention and Early Intervention Program for Psychoses (Elgin-PEPP),
      Regional Mental Health Care, St.Thomas, Ontario, Canada.
FAU - McGorry, P D
AU  - McGorry PD
FAU - Tsuang, Ming
AU  - Tsuang M
FAU - Woods, Scott W
AU  - Woods SW
FAU - Cornblatt, Barbara A
AU  - Cornblatt BA
FAU - Corcoran, Cheryl
AU  - Corcoran C
FAU - Carpenter, William
AU  - Carpenter W
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Psychiatry
JT  - Indian journal of psychiatry
JID - 0013255
PMC - PMC3056191
EDAT- 2011/03/25 06:00
MHDA- 2011/03/25 06:01
CRDT- 2011/03/25 06:00
PHST- 2011/03/25 06:00 [entrez]
PHST- 2011/03/25 06:00 [pubmed]
PHST- 2011/03/25 06:01 [medline]
AID - 10.4103/0019-5545.75560 [doi]
PST - ppublish
SO  - Indian J Psychiatry. 2011 Jan;53(1):57-65. doi: 10.4103/0019-5545.75560.


PMID- 21430654
OWN - NLM
STAT- MEDLINE
DCOM- 20111013
LR  - 20110620
IS  - 1935-3456 (Electronic)
IS  - 1933-0219 (Linking)
VI  - 4
IP  - 4
DP  - 2011 Jul
TI  - Coming of age: reconstruction of heterosexual HIV-1 transmission in human ex vivo
      organ culture systems.
PG  - 383-96
LID - 10.1038/mi.2011.12 [doi]
AB  - Heterosexual transmission of human immunodeficiency virus-1 (HIV-1), from men to 
      women, involves exposure to infectious HIV-1 in semen. Therefore, the cellular
      and molecular processes that underlie HIV-1 transmission are closely
      interconnected with fundamental principles of human reproductive biology. Human
      ex vivo organ culture systems allow experimental reconstruction of HIV-1
      transmission, using human semen and premenopausal cervicovaginal mucosal tissue, 
      with specific emphasis on the progression from exposure to development of primary
      HIV-1 infection. Clearly, an isolated piece of human tissue cannot duplicate the 
      full complexity of events in natural infections, but with correct observation of 
      conventional medical and ethical standards, there is no opportunity to study
      HIV-1 exposure and primary infection in young women. Human mucosal organ cultures
      allow direct study of HIV-1 infection in a reproducible format while retaining
      major elements of complexity and variability that typify community-based HIV-1
      transmission. Experimental manipulation of human mucosal tissue both allows and
      requires acquisition of new insights into basic processes of human mucosal
      immunology. Expanding from the current foundations, we believe that human organ
      cultures will become increasingly prominent in experimental studies of HIV-1
      transmission and continuing efforts to prevent HIV-1 infection at human mucosal
      surfaces.
FAU - Southern, P J
AU  - Southern PJ
AD  - Department of Microbiology, University of Minnesota, Minneapolis, Minnesota, USA.
      south003@umn.edu
FAU - Horbul, J E
AU  - Horbul JE
FAU - Miller, B R L
AU  - Miller BR
FAU - Maher, D M
AU  - Maher DM
LA  - eng
GR  - DE 15090/DE/NIDCR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20110323
PL  - United States
TA  - Mucosal Immunol
JT  - Mucosal immunology
JID - 101299742
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/*immunology/*transmission
MH  - Cervix Uteri/cytology/immunology/virology
MH  - Disease Progression
MH  - Epithelium/immunology/virology
MH  - Female
MH  - HIV-1/*physiology
MH  - Heterosexuality
MH  - Humans
MH  - Male
MH  - Mucous Membrane/immunology/virology
MH  - Organ Culture Techniques
MH  - Semen/virology
EDAT- 2011/03/25 06:00
MHDA- 2011/10/14 06:00
CRDT- 2011/03/25 06:00
PHST- 2011/03/25 06:00 [entrez]
PHST- 2011/03/25 06:00 [pubmed]
PHST- 2011/10/14 06:00 [medline]
AID - mi201112 [pii]
AID - 10.1038/mi.2011.12 [doi]
PST - ppublish
SO  - Mucosal Immunol. 2011 Jul;4(4):383-96. doi: 10.1038/mi.2011.12. Epub 2011 Mar 23.


PMID- 21430613
OWN - NLM
STAT- MEDLINE
DCOM- 20110404
LR  - 20220408
IS  - 2380-8942 (Electronic)
IS  - 2380-8942 (Linking)
VI  - 60
IP  - 1
DP  - 2011 Jan 14
TI  - Rationale for regular reporting on health disparities and inequalities - United
      States.
PG  - 3-10
AB  - Most U.S. residents want a society in which all persons live long, healthy lives;
      however, that vision is yet to be realized fully. As two of its primary goals,
      CDC aims to reduce preventable morbidity and mortality and to eliminate
      disparities in health between segments of the U.S. population. The first of its
      kind, this 2011 CDC Health Disparities and Inequalities Report (2011 CHDIR)
      represents a milestone in CDC's long history of working to eliminate disparities.
      Health disparities are differences in health outcomes and their determinants
      between segments of the population, as defined by social, demographic,
      environmental, and geographic attributes. Health inequalities, which is sometimes
      used interchangeably with the term health disparities, is more often used in the 
      scientific and economic literature to refer to summary measures of population
      health associated with individual- or group-specific attributes (e.g., income,
      education, or race/ethnicity). Health inequities are a subset of health
      inequalities that are modifiable, associated with social disadvantage, and
      considered ethically unfair. Health disparities, inequalities, and inequities are
      important indicators of community health and provide information for decision
      making and intervention implementation to reduce preventable morbidity and
      mortality. Except in the next section of this report that describes selected
      health inequalities, this report uses the term health disparities as it is
      defined in U.S. federal laws and commonly used in the U.S. public health
      literature to refer to gaps in health between segments of the population.
FAU - Truman, Benedict I
AU  - Truman BI
AD  - Epidemiology and Analysis Program Office, CDC, Atlanta, GA 30333, USA.
      bit1@cdc.gov
FAU - Smith, Kay C
AU  - Smith KC
FAU - Roy, Kakoli
AU  - Roy K
FAU - Chen, Zhuo
AU  - Chen Z
FAU - Moonesinghe, Ramal
AU  - Moonesinghe R
FAU - Zhu, Julia
AU  - Zhu J
FAU - Crawford, Carol Gotway
AU  - Crawford CG
FAU - Zaza, Stephanie
AU  - Zaza S
CN  - Centers for Disease Control and Prevention (CDC)
LA  - eng
PT  - Journal Article
PL  - United States
TA  - MMWR Suppl
JT  - MMWR supplements
JID - 101677337
SB  - IM
MH  - Data Collection
MH  - Female
MH  - *Health Status Disparities
MH  - Health Status Indicators
MH  - Humans
MH  - Male
MH  - *Public Health
MH  - United States/epidemiology
EDAT- 2011/03/25 06:00
MHDA- 2011/04/05 06:00
CRDT- 2011/03/25 06:00
PHST- 2011/03/25 06:00 [entrez]
PHST- 2011/03/25 06:00 [pubmed]
PHST- 2011/04/05 06:00 [medline]
AID - su6001a2 [pii]
PST - ppublish
SO  - MMWR Suppl. 2011 Jan 14;60(1):3-10.


PMID- 21430537
OWN - NLM
STAT- MEDLINE
DCOM- 20110808
LR  - 20110413
IS  - 1473-6578 (Electronic)
IS  - 0951-7367 (Linking)
VI  - 24
IP  - 3
DP  - 2011 May
TI  - Ethical and policy issues in using vaccines to treat and prevent cocaine and
      nicotine dependence.
PG  - 191-6
LID - 10.1097/YCO.0b013e328345922b [doi]
AB  - PURPOSE OF REVIEW: To describe the rationale of vaccines against cocaine and
      nicotine, to review progress in developing and trialing vaccines to treat
      dependence on these drugs and to discuss some of the ethical issues that may
      arise from their use in legally coerced addiction treatment or for prevention of 
      addiction in adolescents. RECENT FINDINGS: Several randomized controlled trials
      of cocaine and nicotine vaccines for relapse prevention have produced mixed
      results. The studies demonstrate that it is possible to raise antibodies to
      cocaine and nicotine in humans. In abstinent patients who show high levels of
      drug antibodies, the rewarding effects of these drugs are attenuated. Phase 2
      trials have not found nicotine vaccines to be superior to placebo because only a 
      third of those vaccinated develop sufficient levels of antibody to block the
      effects of nicotine. SUMMARY: Vaccines are a novel approach to relapse prevention
      that need to more reliably induce immunity in a larger proportion of vaccinated
      patients if they are to protect against relapse after achieving abstinence.
      Vaccines are unlikely to prevent addiction in adolescents. Their use under legal 
      coercion should only be considered after considerable experience with their use
      in voluntary patients.
FAU - Hall, Wayne
AU  - Hall W
AD  - Queensland Brain Institute, The University of Queensland, Brisbane, Queensland,
      Australia. w.hall@uq.edu.au
FAU - Gartner, Coral
AU  - Gartner C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Curr Opin Psychiatry
JT  - Current opinion in psychiatry
JID - 8809880
RN  - 0 (Vaccines)
SB  - IM
MH  - Cocaine-Related Disorders/*drug therapy
MH  - Humans
MH  - Policy
MH  - Randomized Controlled Trials as Topic
MH  - Recurrence
MH  - Tobacco Use Disorder/*drug therapy
MH  - Vaccination/*ethics/*legislation & jurisprudence
MH  - Vaccines/immunology/*therapeutic use
EDAT- 2011/03/25 06:00
MHDA- 2011/08/09 06:00
CRDT- 2011/03/25 06:00
PHST- 2011/03/25 06:00 [entrez]
PHST- 2011/03/25 06:00 [pubmed]
PHST- 2011/08/09 06:00 [medline]
AID - 10.1097/YCO.0b013e328345922b [doi]
PST - ppublish
SO  - Curr Opin Psychiatry. 2011 May;24(3):191-6. doi: 10.1097/YCO.0b013e328345922b.


PMID- 21430534
OWN - NLM
STAT- MEDLINE
DCOM- 20110808
LR  - 20110413
IS  - 1473-6578 (Electronic)
IS  - 0951-7367 (Linking)
VI  - 24
IP  - 3
DP  - 2011 May
TI  - A review of current ethical concerns and challenges in substance use disorder
      research.
PG  - 186-90
LID - 10.1097/YCO.0b013e328345926a [doi]
AB  - PURPOSE OF REVIEW: To consider and summarize provocative and important
      publications from 2009 and 2010 related to the ethics of international substance 
      use disorder research. RECENT FINDINGS: This review highlights publications
      related to the interconnected areas of responsible conduct of research, human
      participant protections and the increasingly important area of community concerns
      in research, all within the larger realm of ethical concerns. Ongoing concerns
      highlighted include standards for conflict of interest, recruitment and
      remuneration practices. Other literature discussed expands the ethical dialogue
      to consider the community perspective on research, stigmatization of drug users
      from research and the absence of the 'moral voice' of drug users in ethical
      decision-making. SUMMARY: Ethical dilemmas are inherent in the pursuit of any
      research; in substance use disorder research, often situated in a community with 
      at-risk populations, questions such as who sets the research agenda and what
      norms are followed are critically important. Responsible research that protects
      participants and their communities internationally requires ongoing vigilance.
FAU - Striley, Catherine W
AU  - Striley CW
AD  - Department of Psychiatry, Washington University School of Medicine, 40 N.
      Kingshighway, Suite 4, St Louis, MO 63108, USA. strileyc@epi.wustl.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Psychiatry
JT  - Current opinion in psychiatry
JID - 8809880
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Conflict of Interest
MH  - *Ethics, Research
MH  - Humans
MH  - Patient Selection/ethics
MH  - *Substance-Related Disorders
EDAT- 2011/03/25 06:00
MHDA- 2011/08/09 06:00
CRDT- 2011/03/25 06:00
PHST- 2011/03/25 06:00 [entrez]
PHST- 2011/03/25 06:00 [pubmed]
PHST- 2011/08/09 06:00 [medline]
AID - 10.1097/YCO.0b013e328345926a [doi]
PST - ppublish
SO  - Curr Opin Psychiatry. 2011 May;24(3):186-90. doi: 10.1097/YCO.0b013e328345926a.


PMID- 21430348
OWN - NLM
STAT- MEDLINE
DCOM- 20110715
LR  - 20110324
IS  - 2384-8553 (Electronic)
IS  - 0021-2571 (Linking)
VI  - 47
IP  - 1
DP  - 2011
TI  - Clinical trials and gender medicine.
PG  - 100-3
LID - 10.4415/ANN_11_01_20 [doi]
AB  - Women use more medicines than men because they fall ill more often and suffer
      more from chronic diseases, but also because women pay more attention to their
      health and have more consciousness and care about themselves. Although medicines 
      can have different effects on women and men, women still represent a small
      percentage in the first phases of trials (22%) which are essential to verify
      drugs dosage, side effects, and safety. Even though women are more present in
      trials, studies results are not presented with a gender approach. This situation 
      is due to educational, social, ethical and economical factors. The scientific
      research must increase feminine presence in clinical trials in order to be equal 
      and correct, and all the key stakeholder should be involved in this process. We
      still have a long way to cover and it doesn't concern only women but also
      children and old people. The aim is to have a medicine not only illness-focused
      but patient-focused: a medicine able to take into consideration all the patient
      characteristics and so to produce a really personalized therapy. What above
      described is part of the reasons why in 2005 was founded the National Observatory
      for Women's Health (Osservatorio Nazionale sulla Salute della Donna, ONDa) which 
      promotes a gender health awareness and culture in Italy, at all the levels of the
      civil and scientific society.
FAU - Cassese, Mariarita
AU  - Cassese M
AD  - Osservatorio Nazionale sulla Salute della Donna (ONDa), Milan, Italy.
      m.cassese@ondaosservatorio.it
FAU - Zuber, Veronica
AU  - Zuber V
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - Ann Ist Super Sanita
JT  - Annali dell'Istituto superiore di sanita
JID - 7502520
SB  - IM
MH  - *Clinical Trials as Topic
MH  - Female
MH  - Gender Identity
MH  - Humans
MH  - Italy
MH  - Male
MH  - *Women
MH  - Women's Health
EDAT- 2011/03/25 06:00
MHDA- 2011/07/16 06:00
CRDT- 2011/03/25 06:00
PHST- 2011/03/25 06:00 [entrez]
PHST- 2011/03/25 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
AID - 10.4415/ANN_11_01_20 [doi]
PST - ppublish
SO  - Ann Ist Super Sanita. 2011;47(1):100-3. doi: 10.4415/ANN_11_01_20.


PMID- 21430340
OWN - NLM
STAT- MEDLINE
DCOM- 20110715
LR  - 20110324
IS  - 2384-8553 (Electronic)
IS  - 0021-2571 (Linking)
VI  - 47
IP  - 1
DP  - 2011
TI  - Need to improve clinical trials in rare neurodegenerative disorders.
PG  - 55-9
LID - 10.4415/ANN_11_01_12 [doi]
AB  - Rare neurodegenerative diseases are fatal and no therapy is available to cure or 
      slow down the progression of disease. We report possibly weaknesses in the
      management of clinical studies in these diseases, ranging from poor preclinical
      studies, difficulties in the recruitment of patients, delay in the onset of
      treatment because of lack in early disease-specific biomarkers, and suboptimal
      design of Phase II clinical trials. The adoption of innovative statistical
      approaches in early Phase II trials might improve the screening of drugs in rare 
      neurodegenerative disorders, but this implicates efforts from clinical
      researchers, statisticians, and regulatory people to the development of new
      strategies that should maintain rigorous scientific integrity together with a
      more ethical approach to human experimentations.
FAU - Puopolo, Maria
AU  - Puopolo M
AD  - Dipartimento di Biologia Cellulare e Neuroscienze, Istituto Superiore di Sanita, 
      Rome, Italy.
FAU - Pocchiari, Maurizio
AU  - Pocchiari M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - Ann Ist Super Sanita
JT  - Annali dell'Istituto superiore di sanita
JID - 7502520
SB  - IM
MH  - Animals
MH  - Clinical Trials as Topic/*trends
MH  - Drug Evaluation, Preclinical
MH  - Health Services Needs and Demand
MH  - Humans
MH  - Neurodegenerative Diseases/*therapy
MH  - Patient Selection
MH  - Rare Diseases/*therapy
MH  - Research Design
EDAT- 2011/03/25 06:00
MHDA- 2011/07/16 06:00
CRDT- 2011/03/25 06:00
PHST- 2011/03/25 06:00 [entrez]
PHST- 2011/03/25 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
AID - 10.4415/ANN_11_01_12 [doi]
PST - ppublish
SO  - Ann Ist Super Sanita. 2011;47(1):55-9. doi: 10.4415/ANN_11_01_12.


PMID- 21429960
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20220318
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 6
DP  - 2011 Jun
TI  - A taxonomy of multinational ethical and methodological standards for clinical
      trials of therapeutic interventions.
PG  - 368-73
LID - 10.1136/jme.2010.039255 [doi]
AB  - BACKGROUND: If trials of therapeutic interventions are to serve society's
      interests, they must be of high methodological quality and must satisfy moral
      commitments to human subjects. The authors set out to develop a clinical-trials
      compendium in which standards for the ethical treatment of human subjects are
      integrated with standards for research methods. METHODS: The authors rank-ordered
      the world's nations and chose the 31 with >700 active trials as of 24 July 2008. 
      Governmental and other authoritative entities of the 31 countries were searched, 
      and 1004 English-language documents containing ethical and/or methodological
      standards for clinical trials were identified. The authors extracted standards
      from 144 of those: 50 designated as 'core', 39 addressing trials of invasive
      procedures and a 5% sample (N=55) of the remainder. As the integrating framework 
      for the standards we developed a coherent taxonomy encompassing all elements of a
      trial's stages. FINDINGS: Review of the 144 documents yielded nearly 15 000
      discrete standards. After duplicates were removed, 5903 substantive standards
      remained, distributed in the taxonomy as follows: initiation, 1401 standards, 8
      divisions; design, 1869 standards, 16 divisions; conduct, 1473 standards, 8
      divisions; analysing and reporting results, 997 standards, four divisions; and
      post-trial standards, 168 standards, 5 divisions. CONCLUSIONS: The overwhelming
      number of source documents and standards uncovered in this study was not
      anticipated beforehand and confirms the extraordinary complexity of the clinical 
      trials enterprise. This taxonomy of multinational ethical and methodological
      standards may help trialists and overseers improve the quality of clinical
      trials, particularly given the globalisation of clinical research.
FAU - Ashton, Carol M
AU  - Ashton CM
AD  - Department of Surgery, The Methodist Hospital Research Institute, The Methodist
      Hospital, Houston, TX 77030, USA. cashton@tmhs.org
FAU - Wray, Nelda P
AU  - Wray NP
FAU - Jarman, Anna F
AU  - Jarman AF
FAU - Kolman, Jacob M
AU  - Kolman JM
FAU - Wenner, Danielle M
AU  - Wenner DM
FAU - Brody, Baruch A
AU  - Brody BA
LA  - eng
GR  - R01 CA134995/CA/NCI NIH HHS/United States
GR  - R01CA134995/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110323
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Biomedical Research/*ethics/standards
MH  - Clinical Trials as Topic/*ethics/standards
MH  - Drug Therapy/ethics/standards
MH  - Humans
MH  - Informed Consent/*ethics/standards
MH  - International Cooperation
MH  - Research Design/*standards
PMC - PMC3571710
MID - NIHMS438886
EDAT- 2011/03/25 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/03/25 06:00
PHST- 2011/03/25 06:00 [entrez]
PHST- 2011/03/25 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - jme.2010.039255 [pii]
AID - 10.1136/jme.2010.039255 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Jun;37(6):368-73. doi: 10.1136/jme.2010.039255. Epub 2011 Mar 
      23.


PMID- 21429959
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20181201
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 6
DP  - 2011 Jun
TI  - Normative consent and organ donation: a vindication.
PG  - 362-3
LID - 10.1136/jme.2010.039990 [doi]
AB  - In an earlier article, I argued that David Estlund's notion of 'normative
      consent' could provide justification for an opt-out system of organ donation that
      does not involve presumptions about the deceased donor's consent. Where it would 
      be wrong of someone to refuse their consent, then the fact that they have not
      actually given it is irrelevant, though an explicit denial of consent (as in
      opting out) may still be binding. My argument has recently been criticised by
      Potts et al, who argue that such a policy would involve taking organs from people
      whose organs should not be taken and would be a recipe for totalitarianism. The
      present response seeks to rebut both the ethical and political objections. I
      argue that people can indeed be under a moral obligation to donate their organs, 
      even if they are not technically dead at the time and their donation does not
      save anyone else's life. Moreover, I argue that an opt-out system-unlike
      mandatory donation-is not totalitarian because it preserves the right of
      individuals to act morally wrongly, by opting out when they have no good moral
      reason to do so. The policy I propose is neither immoral nor totalitarian.
FAU - Saunders, Ben
AU  - Saunders B
AD  - Philosophy, University of Stirling, Stirling, UK. ben.saunders@stir.ac.uk
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20110323
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
CON - J Med Ethics. 2010 Aug;36(8):498-9. PMID: 20663768
MH  - Humans
MH  - Presumed Consent/*ethics
MH  - Refusal to Participate/*ethics
MH  - Tissue and Organ Procurement/*ethics
EDAT- 2011/03/25 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/03/25 06:00
PHST- 2011/03/25 06:00 [entrez]
PHST- 2011/03/25 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - jme.2010.039990 [pii]
AID - 10.1136/jme.2010.039990 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Jun;37(6):362-3. doi: 10.1136/jme.2010.039990. Epub 2011 Mar
      23.


PMID- 21429958
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20181201
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 8
DP  - 2011 Aug
TI  - Women's views on the moral status of nature in the context of prenatal screening 
      decisions.
PG  - 461-5
LID - 10.1136/jme.2010.040592 [doi]
AB  - Appeals to the moral authority of nature play an important role in ethical
      discussions about the acceptability of prenatal testing. While opponents consider
      testing a dangerous violation of the moral inviolable course of nature, defenders
      see testing as a new step in improving dominion over nature. In this study we
      explored the meaning of appeals to nature among pregnant women to whom a prenatal
      screening test was offered and the impact of these appeals on their choices
      regarding the acceptance of screening. Contrary to theoretical debates we found
      that appeals to the moral authority of nature do not prevent women from welcoming
      the possibilities of controlling the outcomes of pregnancy, neither do they
      provide prima facie justification for (not) intervening in the natural course of 
      events. Both acceptors and decliners believed in an inherent morality in nature
      that must be respected. They welcome the possibility of knowing more about the
      health of the fetus and to make their own reproductive decisions. Concerns for
      the quality of their child's life and for their capacity to assure a good life
      for their family and disabled child appear to play a central role in the decision
      regarding the use of screening. Appeals to nature can be interpreted as an
      attempt to justify beliefs regarding suffering that must be avoided and the
      impact that family interests may have on the decision. These findings have
      significant implications for ethical guidance in debates about the acceptability 
      and boundaries of control of offspring characteristics by prenatal testing.
FAU - Garcia, Elisa
AU  - Garcia E
AD  - Department of Ethics, Philosophy and History of Medicine, University Medical
      Center St Radboud, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
      e.garciagonzalez@iq.umcn.nl
FAU - Timmermans, Danielle R M
AU  - Timmermans DR
FAU - van Leeuwen, Evert
AU  - van Leeuwen E
LA  - eng
PT  - Journal Article
DEP - 20110323
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Decision Making/ethics
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - *Morals
MH  - Patient Acceptance of Health Care/*psychology
MH  - Pregnancy
MH  - Pregnant Women/*psychology
MH  - Prenatal Care/*ethics
MH  - Prenatal Diagnosis/*ethics/psychology/statistics & numerical data
MH  - Qualitative Research
MH  - Randomized Controlled Trials as Topic
EDAT- 2011/03/25 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/03/25 06:00
PHST- 2011/03/25 06:00 [entrez]
PHST- 2011/03/25 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - jme.2010.040592 [pii]
AID - 10.1136/jme.2010.040592 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Aug;37(8):461-5. doi: 10.1136/jme.2010.040592. Epub 2011 Mar
      23.


PMID- 21429797
OWN - NLM
STAT- MEDLINE
DCOM- 20120308
LR  - 20220409
IS  - 1532-2122 (Electronic)
IS  - 1462-3889 (Linking)
VI  - 15
IP  - 5
DP  - 2011 Dec
TI  - Are paediatric oncology nurses acknowledging the effects of restraint? A review
      of the current policy and research.
PG  - 513-8
LID - 10.1016/j.ejon.2011.02.001 [doi]
AB  - PURPOSE: The literature pertaining to restraint of children for procedures and
      administration of medication continues to indicate this is a widespread
      phenomenon and that nurses caring for children often fail to consider effects of 
      this. This paper reviews the current literature and policy surrounding the
      practice of paediatric restraint within oncology nursing. METHOD: A review of
      research and policy identified three significant themes relating to restraint:
      effects of restraint on the family, professional considerations; ethical and
      legal implications. RESULTS: This paper through an analysis of the literature and
      policy demonstrates that paediatric restraint is a contentious issue in
      children's oncology nursing and that while essential in many cases, requires
      careful consideration. Alternatives to restraint should always be considered to
      minimise the effect upon child and family. CONCLUSIONS: A number of key issues
      are highlighted in this paper which would be useful. Most importantly the notion 
      of children's rights, negotiation and partnership with children and their
      families and the nurses responsibility in relation to the law and the Nursing and
      Midwifery Council. Professional bodies such as the Royal College of Nursing have 
      attempted to offer guidance in this area; the key message is that restraint
      should always be the last option; it is our opinion that often it is the first.
CI  - Copyright A(c) 2011 Elsevier Ltd. All rights reserved.
FAU - Hull, Ken
AU  - Hull K
AD  - Bristol Royal Hospital for Children, Bristol BS2 8BJ, UK.
      ken.hull@uhbristol.nhs.uk
FAU - Clarke, Dave
AU  - Clarke D
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110322
PL  - Scotland
TA  - Eur J Oncol Nurs
JT  - European journal of oncology nursing : the official journal of European Oncology 
      Nursing Society
JID - 100885136
SB  - IM
MH  - Child
MH  - Child, Hospitalized/psychology
MH  - Family/psychology
MH  - Health Policy
MH  - Humans
MH  - *Nurse-Patient Relations
MH  - Nursing Methodology Research
MH  - Oncology Nursing/*methods
MH  - Pediatric Nursing/*methods
MH  - *Restraint, Physical/ethics/legislation & jurisprudence/psychology
EDAT- 2011/03/25 06:00
MHDA- 2012/03/09 06:00
CRDT- 2011/03/25 06:00
PHST- 2009/08/13 00:00 [received]
PHST- 2011/01/27 00:00 [revised]
PHST- 2011/02/05 00:00 [accepted]
PHST- 2011/03/25 06:00 [entrez]
PHST- 2011/03/25 06:00 [pubmed]
PHST- 2012/03/09 06:00 [medline]
AID - S1462-3889(11)00017-2 [pii]
AID - 10.1016/j.ejon.2011.02.001 [doi]
PST - ppublish
SO  - Eur J Oncol Nurs. 2011 Dec;15(5):513-8. doi: 10.1016/j.ejon.2011.02.001. Epub
      2011 Mar 22.


PMID- 21429638
OWN - NLM
STAT- MEDLINE
DCOM- 20120608
LR  - 20120220
IS  - 1532-2793 (Electronic)
IS  - 0260-6917 (Linking)
VI  - 32
IP  - 3
DP  - 2012 Apr
TI  - Ethical conduct in nurse education: creating safe staff-student boundaries.
PG  - 320-4
LID - 10.1016/j.nedt.2011.02.013 [doi]
AB  - This article synthesises principles and ideas from relevant literature on
      professional boundaries and applies them to higher education settings with the
      intention of contributing to contemporary debates on appropriate, respectful, and
      ethical conduct in academia. This is against a background of structural changes
      and growing complexity of academic institutions in concert with decreasing
      adherence to rules of conduct and established privileges historically handed down
      from traditional universities. The professional and personal conduct of nurse
      academics is increasingly unfettered in association with 'market' forces and
      simultaneously more available for scrutiny in association with a greater
      awareness of and institutionalisation of human rights and protections across all 
      sectors of society.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Cleary, Michelle
AU  - Cleary M
AD  - Family and Community Health Research Group, School of Nursing and Midwifery,
      University of Western Sydney, Sydney, NSW, Australia. m.cleary@uws.edu.au
FAU - Horsfall, Jan
AU  - Horsfall J
FAU - Jackson, Debra
AU  - Jackson D
FAU - Hunt, Glenn E
AU  - Hunt GE
LA  - eng
PT  - Journal Article
DEP - 20110323
PL  - Scotland
TA  - Nurse Educ Today
JT  - Nurse education today
JID - 8511379
MH  - Education, Nursing/*ethics/organization & administration
MH  - *Faculty, Nursing
MH  - Humans
MH  - Interprofessional Relations/*ethics
MH  - Nursing Education Research
MH  - Organizational Culture
MH  - Safety Management
MH  - *Students, Nursing
EDAT- 2011/03/25 06:00
MHDA- 2012/06/09 06:00
CRDT- 2011/03/25 06:00
PHST- 2010/12/17 00:00 [received]
PHST- 2011/02/22 00:00 [revised]
PHST- 2011/02/25 00:00 [accepted]
PHST- 2011/03/25 06:00 [entrez]
PHST- 2011/03/25 06:00 [pubmed]
PHST- 2012/06/09 06:00 [medline]
AID - S0260-6917(11)00059-1 [pii]
AID - 10.1016/j.nedt.2011.02.013 [doi]
PST - ppublish
SO  - Nurse Educ Today. 2012 Apr;32(3):320-4. doi: 10.1016/j.nedt.2011.02.013. Epub
      2011 Mar 23.


PMID- 21429277
OWN - NLM
STAT- MEDLINE
DCOM- 20140414
LR  - 20161020
IS  - 1741-203X (Electronic)
IS  - 1041-6102 (Linking)
VI  - 23
IP  - 9
DP  - 2011 Nov
TI  - Comfort with proxy consent to research involving decisionally impaired older
      adults: do type of proxy and risk-benefit profile matter?
PG  - 1479-88
LID - 10.1017/S1041610211000433 [doi]
AB  - BACKGROUND: Dementia research often requires the participation of people with
      dementia. Obtaining informed consent is problematic when potential participants
      lack the capacity to provide it. We investigated comfort with proxy consent to
      research involving older adults deemed incapable of this decision, and examined
      if comfort varies with the type of proxy and the study's risk-benefit profile.
      METHODS: We surveyed random samples of five relevant groups (older adults,
      informal caregivers, physicians, researchers in aging, and Research Ethics Board 
      members) from four Canadian provinces. Respondents were presented with scenarios 
      involving four types of proxies (non-assigned, designated in a healthcare advance
      directive with or without instructions specific to research participation, and
      court-appointed). Given a series of risk-benefit profiles, respondents indicated 
      whether they were comfortable with proxy consent to research for each scenario.
      RESULTS: Two percent of the respondents felt proxy consent should never be
      allowed. In all groups, comfort depended far more on the risk-benefit profile
      associated with the research scenario than with type of proxy. For research
      involving little or no risk and potential personal benefits, over 90% of the
      respondents felt comfortable with substitute consent by a designated or
      court-appointed proxy while 80% were at ease with a non-assigned proxy. For
      studies involving serious risks with potentially greater personal benefits, older
      adults and informal caregivers were less comfortable with proxy consent.
      CONCLUSIONS: A large majority of Canadians are comfortable with proxy consent for
      low-risk research. Further work is needed to establish what kinds of research are
      considered to be low risk.
FAU - Dubois, Marie-France
AU  - Dubois MF
AD  - Department of Community Health Sciences, University of Sherbrooke, Sherbrooke,
      Quebec, Canada. Marie-France.Dubois@USherbrooke.ca
FAU - Bravo, Gina
AU  - Bravo G
FAU - Graham, Janice
AU  - Graham J
FAU - Wildeman, Sheila
AU  - Wildeman S
FAU - Cohen, Carole
AU  - Cohen C
FAU - Painter, Karen
AU  - Painter K
FAU - Bellemare, Suzanne
AU  - Bellemare S
LA  - eng
GR  - 200409MOP/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110324
PL  - England
TA  - Int Psychogeriatr
JT  - International psychogeriatrics
JID - 9007918
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Canada
MH  - Data Collection
MH  - Dementia/*psychology
MH  - Ethics, Research
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Proxy
MH  - *Third-Party Consent/ethics
MH  - Young Adult
EDAT- 2011/03/25 06:00
MHDA- 2014/04/15 06:00
CRDT- 2011/03/25 06:00
PHST- 2011/03/25 06:00 [entrez]
PHST- 2011/03/25 06:00 [pubmed]
PHST- 2014/04/15 06:00 [medline]
AID - S1041610211000433 [pii]
AID - 10.1017/S1041610211000433 [doi]
PST - ppublish
SO  - Int Psychogeriatr. 2011 Nov;23(9):1479-88. doi: 10.1017/S1041610211000433. Epub
      2011 Mar 24.


PMID- 21428029
OWN - NLM
STAT- MEDLINE
DCOM- 20110504
LR  - 20140102
IS  - 1827-6806 (Print)
IS  - 1827-6806 (Linking)
VI  - 12
IP  - 1
DP  - 2011 Jan
TI  - [Withholding and withdrawing therapy in cardiac intensive care units: ethical and
      clinical criteria in end-of-life decisions].
PG  - 50-7
AB  - In the last years dramatic changes in clinical and epidemiological
      characteristics of patients admitted to cardiac intensive care units have been
      observed. Aging population, non-ischemic cardiovascular diseases, acute and
      chronic severe comorbidities, all increased the susceptibility to develop
      life-threatening critical settings. In this context, palliative care programs are
      needed more frequently. In this review, the ethical and clinical criteria to
      withdrawing and withholding artificial cardiocirculatory, respiratory and renal
      supports are analyzed, as well as the cultural delays of cardiologists involved
      in this peculiar clinical setting.
FAU - Romano, Massimo
AU  - Romano M
AD  - S.C. di Cardiologia, Ospedale di Vigevano, Azienda Ospedaliera Provincia di
      Pavia. max.romano51@gmail.com
LA  - ita
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - La desistenza terapeutica in unita di terapia intensiva cardiologica: criteri
      decisionali fra etica e clinica.
PL  - Italy
TA  - G Ital Cardiol (Rome)
JT  - Giornale italiano di cardiologia (2006)
JID - 101263411
SB  - IM
CIN - G Ital Cardiol (Rome). 2013 Oct;14(10):647-9. PMID: 24121888
MH  - Cardiology/*ethics
MH  - Decision Making
MH  - Heart Diseases/*therapy
MH  - Humans
MH  - *Intensive Care Units
MH  - Palliative Care/*ethics
MH  - Withholding Treatment/*ethics
EDAT- 2011/03/25 06:00
MHDA- 2011/05/05 06:00
CRDT- 2011/03/25 06:00
PHST- 2011/03/25 06:00 [entrez]
PHST- 2011/03/25 06:00 [pubmed]
PHST- 2011/05/05 06:00 [medline]
PST - ppublish
SO  - G Ital Cardiol (Rome). 2011 Jan;12(1):50-7.


PMID- 21428011
OWN - NLM
STAT- MEDLINE
DCOM- 20110526
LR  - 20110323
IS  - 0210-5020 (Print)
IS  - 0210-5020 (Linking)
VI  - 34
IP  - 1
DP  - 2011 Jan
TI  - [Hydration in clinical practice].
PG  - 59-64
AB  - Water is an essential foundation for life, having both a regulatory and
      structural function. The former results from active and passive participation in 
      all metabolic reactions, and its role in conserving and maintaining body
      temperature. Structurally speaking it is the major contributer to tissue mass,
      accounting for 60% of the basis of blood plasma, intracellular and intersticial
      fluid. Water is also part of the primary structures of life such as genetic
      material or proteins. Therefore, it is necessary that the nurse makes an early
      assessment of patients water needs to detect if there are signs of electrolyte
      imbalance. Dehydration can be a very serious problem, especially in children and 
      the elderly. Dehydrations treatment with oral rehydration solution decreases the 
      risk of developing hydration disorders, but even so, it is recommended to follow 
      preventive measures to reduce the incidence and severity of dehydration. The key 
      to having a proper hydration is prevention. Artificial nutrition encompasses the 
      need for precise calculation of water needs in enteral nutrition as parenteral,
      so the nurse should be part of this process and use the tools for calculating the
      patient's requirements. All this helps to ensure an optimal nutritional status in
      patients at risk. Ethical dilemmas are becoming increasingly common in clinical
      practice. On the subject of artificial nutrition and hydration, there isn't yet
      any unanimous agreement regarding hydration as a basic care. It is necessary to
      take decisions in consensus with the health team, always thinking of the best
      interests of the patient.
FAU - Maristany, Cleofe Perez-Portabella
AU  - Maristany CP
AD  - Unidad de Soporte Nutricional Hospital Vall d'Hebron, Barcelona.
FAU - Segurola Gurruchaga, Hegoi
AU  - Segurola Gurruchaga H
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - La hidratacion en la practica clinica.
PL  - Spain
TA  - Rev Enferm
JT  - Revista de enfermeria (Barcelona, Spain)
JID - 8309920
MH  - Dehydration/*therapy
MH  - *Fluid Therapy/standards
MH  - Humans
MH  - Nutritional Support
EDAT- 2011/03/25 06:00
MHDA- 2011/05/27 06:00
CRDT- 2011/03/25 06:00
PHST- 2011/03/25 06:00 [entrez]
PHST- 2011/03/25 06:00 [pubmed]
PHST- 2011/05/27 06:00 [medline]
PST - ppublish
SO  - Rev Enferm. 2011 Jan;34(1):59-64.


PMID- 21427664
OWN - NLM
STAT- MEDLINE
DCOM- 20110607
LR  - 20110323
IS  - 1319-6138 (Print)
IS  - 1319-6138 (Linking)
VI  - 16
IP  - 2
DP  - 2011 Apr
TI  - Determining factors of anxiety in patients at the preoperative stage.
PG  - 146-9
AB  - OBJECTIVE: To estimate patient preoperative anxiety, and determine associated
      factors. METHODS: Fifty surgical patients were investigated prospectively at the 
      University Hospital, Rabat, Morocco between January and June 2008. Ethical
      Committee approval was obtained prior to conducting this study. A short version
      of the Hamilton scale was used. Descriptive statistics, student`s t-test, and
      ANOVA were performed to probe the sociodemographic impact factors on Hamilton
      scores. We investigated scores superior to 14 indicating a pathologic anxiety
      situation. A logistic regression was carried out by including all variables; the 
      significant threshold was 0.15 in single variable analysis, and we retained a
      significant threshold of 0.05 in the final model. RESULTS: A significant decrease
      in anxiety from the preoperative to the postoperative stage was observed in all
      patients of merged surgery groups. Females had higher preoperational anxiety
      compared with males. A longer hospitalization stay and lower knowledge of
      patients regarding their pathologies were the main factors that increased the
      anxiety scores towards a pathological anxiety state. This applied to all
      patients, including higher education and prosperous social classes. CONCLUSION:
      Patient sociodemographic, psychological history, and surgery type have to be
      considered for identifying patients at risk for developing anxiety before and
      after surgery. Psychological support has to be established to avoid additional
      suffering of the patient from anxiety.
FAU - Aalouane, Rachid
AU  - Aalouane R
AD  - Psychiatric Department, University Hospital Ibn Al Hassan, Fez, Morocco.
FAU - Rammouz, Ismail
AU  - Rammouz I
FAU - Tahiri-Alaoui, Driss
AU  - Tahiri-Alaoui D
FAU - Elrhazi, Karima
AU  - Elrhazi K
FAU - Boujraf, Said
AU  - Boujraf S
LA  - eng
PT  - Journal Article
PL  - Saudi Arabia
TA  - Neurosciences (Riyadh)
JT  - Neurosciences (Riyadh, Saudi Arabia)
JID - 101252453
SB  - IM
MH  - Adult
MH  - Aged
MH  - Analysis of Variance
MH  - Anxiety/*etiology/*psychology
MH  - Educational Status
MH  - Female
MH  - Hospitalization
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Preoperative Period
MH  - Retrospective Studies
MH  - Sex Factors
MH  - Surgical Procedures, Operative/*psychology
MH  - Time Factors
MH  - Young Adult
EDAT- 2011/03/24 06:00
MHDA- 2011/06/08 06:00
CRDT- 2011/03/24 06:00
PHST- 2011/03/24 06:00 [entrez]
PHST- 2011/03/24 06:00 [pubmed]
PHST- 2011/06/08 06:00 [medline]
AID - 20100609 [pii]
PST - ppublish
SO  - Neurosciences (Riyadh). 2011 Apr;16(2):146-9.


PMID- 21427594
OWN - NLM
STAT- MEDLINE
DCOM- 20110824
LR  - 20131121
IS  - 1536-0210 (Electronic)
IS  - 0020-9996 (Linking)
VI  - 46
IP  - 6
DP  - 2011 Jun
TI  - Distinguishing hepatic metastasis from hemangioma using gadoxetic acid-enhanced
      magnetic resonance imaging.
PG  - 359-65
LID - 10.1097/RLI.0b013e3182104b77 [doi]
AB  - PURPOSE: To retrospectively determine the findings of gadoxetic acid-enhanced
      magnetic resonance imaging (MRI) to distinguish hemangioma and metastasis of the 
      liver. MATERIALS AND METHODS: The University's ethics committee approved this
      retrospective study. We assessed 45 patients without chronic liver disease who
      underwent gadoxetic acid-enhanced MRI. Diagnosis of 58 metastases and 47
      hemangiomas was confirmed using histopathology or multimodality evaluation. Two
      radiologists independently assessed the following MRI findings of metastasis and 
      hemangioma: their appearance on T2-weighted images (T2WI) and dynamic contrast
      enhancement patterns after gadoxetic acid administration. The metastasis and
      hemangioma findings were compared using Fisher exact test. The lesion-to-liver
      signal intensity ratio on hepatocyte phase was compared using the Mann-Whitney U 
      test. Multivariate analysis was performed to identify independent imaging
      findings distinguishing the 2 diseases. Receiver operating characteristic
      analysis was used to estimate the diagnostic ability of gadoxetic acid-enhanced
      MRI to distinguish metastasis from hemangioma. RESULTS: The lesion-to-liver
      signal intensity ratio was comparable in both diseases. Peripheral-dot
      enhancement, ring-like, geographic, and moderate late-phase enhancement, rapid
      contrast filling, and bright signal on T2WI could differentiate between the 2
      diseases. In multivariate analysis, bright signal on T2WI (94%-98% in hemangioma 
      and 13%-25% in metastasis) and ring-like enhancement (4% in hemangioma and
      58%-60% in metastasis) were the independent findings suggesting hemangioma and
      metastasis, respectively. The areas under the receiver operating characteristic
      curves to distinguish metastasis from hemangioma were 0.95 and 0.98 for Reader 1 
      and 2, respectively. CONCLUSION: Reliable findings to distinguish hepatic
      metastasis from hemangioma on gadoxetic acid-enhanced MRI were ring-like
      enhancement on arterial-phase images and bright signal on T2WI.
FAU - Motosugi, Utaroh
AU  - Motosugi U
AD  - Department of Radiology, University of Yamanashi, Chuo, Japan.
FAU - Ichikawa, Tomoaki
AU  - Ichikawa T
FAU - Onohara, Kojiro
AU  - Onohara K
FAU - Sou, Hironobu
AU  - Sou H
FAU - Sano, Katsuhiro
AU  - Sano K
FAU - Muhi, Ali
AU  - Muhi A
FAU - Araki, Tsutomu
AU  - Araki T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Invest Radiol
JT  - Investigative radiology
JID - 0045377
RN  - 0 (Contrast Media)
RN  - 0 (gadolinium ethoxybenzyl DTPA)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Contrast Media
MH  - Female
MH  - *Gadolinium DTPA
MH  - Hemangioma/*diagnosis
MH  - Humans
MH  - Liver Neoplasms/*diagnosis/pathology
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
EDAT- 2011/03/24 06:00
MHDA- 2011/08/25 06:00
CRDT- 2011/03/24 06:00
PHST- 2011/03/24 06:00 [entrez]
PHST- 2011/03/24 06:00 [pubmed]
PHST- 2011/08/25 06:00 [medline]
AID - 10.1097/RLI.0b013e3182104b77 [doi]
PST - ppublish
SO  - Invest Radiol. 2011 Jun;46(6):359-65. doi: 10.1097/RLI.0b013e3182104b77.


PMID- 21427542
OWN - NLM
STAT- MEDLINE
DCOM- 20110520
LR  - 20110323
IS  - 1528-1175 (Electronic)
IS  - 0003-3022 (Linking)
VI  - 114
IP  - 4
DP  - 2011 Apr
TI  - Ethics and human experimentation.
PG  - 1001-2; author reply 1002-3
LID - 10.1097/ALN.0b013e31820d84fb [doi]
FAU - Butterworth, John F 4th
AU  - Butterworth JF 4th
LA  - eng
PT  - Comment
PT  - Historical Article
PT  - Letter
PL  - United States
TA  - Anesthesiology
JT  - Anesthesiology
JID - 1300217
SB  - IM
CON - Anesthesiology. 2010 Sep;113(3):685-6. PMID: 20693869
CON - Anesthesiology. 2010 Sep;113(3):678-84. PMID: 20693870
MH  - Anesthesiology/ethics/history
MH  - Ethics, Research/*history
MH  - Helsinki Declaration/history
MH  - History, 20th Century
MH  - Human Experimentation/ethics/*history
MH  - Humans
MH  - Informed Consent/ethics/*history
MH  - Prisoners/history
MH  - United States
EDAT- 2011/03/24 06:00
MHDA- 2011/05/21 06:00
CRDT- 2011/03/24 06:00
PHST- 2011/03/24 06:00 [entrez]
PHST- 2011/03/24 06:00 [pubmed]
PHST- 2011/05/21 06:00 [medline]
AID - 10.1097/ALN.0b013e31820d84fb [doi]
AID - 00000542-201104000-00042 [pii]
PST - ppublish
SO  - Anesthesiology. 2011 Apr;114(4):1001-2; author reply 1002-3. doi:
      10.1097/ALN.0b013e31820d84fb.


PMID- 21426482
OWN - NLM
STAT- MEDLINE
DCOM- 20111006
LR  - 20211020
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 11
IP  - 2
DP  - 2011 Aug
TI  - Getting personal: ethics and identity in global health research.
PG  - 82-92
LID - 10.1111/j.1471-8847.2011.00297.x [doi]
AB  - 'Researcher identity' affects global health research in profound and complex
      ways. Anthropologists in particular have led the way in portraying the multiple, 
      and sometimes tension-generating, identities that researchers ascribe to
      themselves, or have ascribed to them, in their places of research. However, the
      central importance of researcher identity in the ethical conduct of global health
      research has yet to be fully appreciated. The capacity of researchers to respond 
      effectively to the ethical tensions surrounding their identities is hampered by
      lack of conceptual clarity, as to the nature and scope of the issues involved.
      This paper strives to provide some clarification of these ethical tensions by
      considering researcher identity from the perspective of (1) Guillemin and
      Heggen's (2009) key distinction between procedural ethics and ethics in practice,
      and (2) our own distinction between perceptions of identity that are either
      symmetrical or asymmetrical, with the potential to shift research relationships
      toward greater or lesser ethical harmony. Discussion of these concepts is
      supported with ethnographic examples from relevant literature and from our own
      (United States (US) Government-funded) research in South Africa. A preliminary
      set of recommendations is provided in an effort to equip researchers with a
      greater sense of organization and control over the ethics of researcher identity.
      The paper concludes that the complex construction of researcher identity needs to
      be central among the ethical concerns of global health researchers, and that the 
      conceptual tools discussed in the paper are a useful starting point for better
      organizing and acting on these ethical concerns.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Simon, Christian
AU  - Simon C
AD  - University of Iowa, Iowa City, IA 52242-1190, USA. christian-simon@uiowa.edu
FAU - Mosavel, Maghboeba
AU  - Mosavel M
LA  - eng
GR  - R03 CA113086/CA/NCI NIH HHS/United States
GR  - R03 CA113086-01A1/CA/NCI NIH HHS/United States
PT  - Journal Article
DEP - 20110322
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
SB  - IM
MH  - Clinical Trials as Topic/*ethics
MH  - Community-Based Participatory Research/*ethics
MH  - Developed Countries
MH  - Developing Countries
MH  - Ethics, Research
MH  - Humans
MH  - Mass Media
MH  - Politics
MH  - Research Personnel/*ethics/psychology/standards
MH  - Research Support as Topic/ethics
MH  - Researcher-Subject Relations/*ethics/psychology
MH  - Residence Characteristics
MH  - *Role
MH  - *Social Identification
MH  - *Social Justice
MH  - *Social Responsibility
MH  - *Truth Disclosure/ethics
PMC - PMC3145018
MID - NIHMS304033
EDAT- 2011/03/24 06:00
MHDA- 2011/10/07 06:00
CRDT- 2011/03/24 06:00
PHST- 2011/03/24 06:00 [entrez]
PHST- 2011/03/24 06:00 [pubmed]
PHST- 2011/10/07 06:00 [medline]
AID - 10.1111/j.1471-8847.2011.00297.x [doi]
PST - ppublish
SO  - Dev World Bioeth. 2011 Aug;11(2):82-92. doi: 10.1111/j.1471-8847.2011.00297.x.
      Epub 2011 Mar 22.


PMID- 21426287
OWN - NLM
STAT- MEDLINE
DCOM- 20110603
LR  - 20201230
IS  - 1326-5377 (Electronic)
IS  - 0025-729X (Linking)
VI  - 194
IP  - 6
DP  - 2011 Mar 21
TI  - Self-audit as part of a research governance framework for health research.
PG  - 310-2
AB  - Clinical research is an area of increasing activity for hospitals, universities
      and research institutions, which requires formal governance and oversight to
      manage risks. Monitoring research practice should be a part of research
      governance activities. However, formal audits have proved time consuming for
      researchers and auditors. To increase attention to good research practice and
      screen for poor practice, the Department of Epidemiology and Preventive Medicine 
      at Monash University and the Alfred Research and Ethics Unit in Melbourne have
      developed a brief self-audit tool for researchers. We evaluated the self-audit
      using a questionnaire for researchers. The results were positive, with most
      respondents believing that it promoted good research practice.
FAU - Crammond, Bradley R
AU  - Crammond BR
AD  - School of Population Health and Preventive Medicine, Monash University,
      Melbourne, VIC, Australia. brad.crammond@med.monash.edu.au
FAU - Parker, Anna V
AU  - Parker AV
FAU - Brooks, Megan
AU  - Brooks M
FAU - Skiba, Marina
AU  - Skiba M
FAU - McNeil, John J
AU  - McNeil JJ
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Med J Aust
JT  - The Medical journal of Australia
JID - 0400714
SB  - IM
MH  - Australia
MH  - Biomedical Research/*standards/trends
MH  - Clinical Governance/organization & administration
MH  - *Ethics, Research
MH  - Female
MH  - Humans
MH  - Male
MH  - Management Audit/organization & administration
MH  - Medical Audit/*organization & administration
MH  - Organizational Policy
MH  - Research Personnel/organization & administration
MH  - *Self-Assessment
MH  - Surveys and Questionnaires
EDAT- 2011/03/24 06:00
MHDA- 2011/06/04 06:00
CRDT- 2011/03/24 06:00
PHST- 2010/05/24 00:00 [received]
PHST- 2010/09/01 00:00 [accepted]
PHST- 2011/03/24 06:00 [entrez]
PHST- 2011/03/24 06:00 [pubmed]
PHST- 2011/06/04 06:00 [medline]
AID - cra10564_fm [pii]
AID - 10.5694/j.1326-5377.2011.tb02981.x [doi]
PST - ppublish
SO  - Med J Aust. 2011 Mar 21;194(6):310-2. doi: 10.5694/j.1326-5377.2011.tb02981.x.


PMID- 21426286
OWN - NLM
STAT- MEDLINE
DCOM- 20110603
LR  - 20201230
IS  - 1326-5377 (Electronic)
IS  - 0025-729X (Linking)
VI  - 194
IP  - 6
DP  - 2011 Mar 21
TI  - Battlefield euthanasia - courageous compassion or war crime?
PG  - 307-9
AB  - Issues relating to voluntary euthanasia that are currently being debated by
      Australian society are distinctly different from those encountered by battlefield
      doctors. Doctors in war undertake to treat those affected by conflict; their
      participation in euthanasia challenges the profession's definition of "duty of
      care". Euthanasia must be distinguished from "triage" and medical withdrawal of
      care (which are decided within a medical facility where, although resources may
      be limited, comfort care can be provided in the face of treatment futility).
      Battlefield euthanasia is a decision made, often immediately after hostile
      action, in the face of apparently overwhelming injuries; there is often limited
      availability of pain relief, support systems or palliation that would be
      available in a civilian environment. The battlefield situation is further
      complicated by issues of personal danger, the immediacy of decision making and
      difficulties with distinguishing civilians from combatants. Regardless of the
      circumstances on a battlefield, doctors, whether they are civilians or members of
      a defence force, are subject to the laws of armed conflict, the special
      provisions of the Geneva Conventions and the ethical codes of the medical
      profession.
FAU - Neuhaus, Susan J
AU  - Neuhaus SJ
AD  - Department of Surgery, University of Adelaide, Adelaide, SA, Australia.
      padrneuhaus@apsa.com.au
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Australia
TA  - Med J Aust
JT  - The Medical journal of Australia
JID - 0400714
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Australia
MH  - Conflict of Interest
MH  - Empathy/ethics
MH  - Euthanasia, Active/*ethics/trends
MH  - Female
MH  - Humans
MH  - Liability, Legal
MH  - Male
MH  - Military Medicine/*ethics/methods
MH  - Practice Patterns, Physicians'
MH  - War Crimes/ethics
MH  - *Warfare
EDAT- 2011/03/24 06:00
MHDA- 2011/06/04 06:00
CRDT- 2011/03/24 06:00
PHST- 2010/06/21 00:00 [received]
PHST- 2010/12/22 00:00 [accepted]
PHST- 2011/03/24 06:00 [entrez]
PHST- 2011/03/24 06:00 [pubmed]
PHST- 2011/06/04 06:00 [medline]
AID - neu10673_fm [pii]
AID - 10.5694/j.1326-5377.2011.tb02980.x [doi]
PST - ppublish
SO  - Med J Aust. 2011 Mar 21;194(6):307-9. doi: 10.5694/j.1326-5377.2011.tb02980.x.


PMID- 21425514
OWN - NLM
STAT- MEDLINE
DCOM- 20111223
LR  - 20191112
IS  - 1532-8651 (Electronic)
IS  - 1098-7339 (Linking)
VI  - 36
IP  - 2
DP  - 2011 Mar-Apr
TI  - Ultrasound guidance improves a continuous popliteal sciatic nerve block when
      compared with nerve stimulation.
PG  - 181-4
AB  - BACKGROUND AND OBJECTIVES: Continuous sciatic nerve blockade at the popliteal
      level effectively alleviates postoperative pain after major foot and ankle
      surgery. No randomized controlled trials have previously compared the success
      rate of continuous sciatic nerve sensory blockade between ultrasound and nerve
      stimulation guidance. In the current study, we tested the hypothesis that
      ultrasound-guided catheter placement improves the success rate of continuous
      sciatic nerve sensory blockade compared with catheter placement with nerve
      stimulation guidance. METHODS: After research ethics committee approval and
      informed consent, 100 patients scheduled for elective major foot and ankle
      surgery were randomly allocated to popliteal catheter placement either with
      ultrasound or nerve stimulation guidance. The primary outcome was the success
      rate of sensory block the first 48 postoperative hours. Successful sensory
      blockade was defined as sensory loss in both the tibial and common peroneal nerve
      territories at 1, 6, 24, and 48 hrs postoperatively. RESULTS: The ultrasound
      group had significantly higher success rate of sensory block compared with the
      nerve stimulation group (94% versus 79%, P=0.03). Ultrasound compared with nerve 
      stimulation guidance also entails reduced morphine consumption (median of 18 mg
      [range, 0-159 mg] versus 34 mg [range, 0-152 mg], respectively, P=0.02), fewer
      needle passes (median of 1 [range, 1-6] versus 2 [range, 1-10], respectively,
      P=0.0005), and greater patient satisfaction (median numeric rating scale 9
      [range, 5-10] versus 8 [range, 3-10)] respectively, P=0.0006) during catheter
      placement. CONCLUSION: Ultrasound guidance used for sciatic catheter placement
      improves the success rate of sensory block, number of needle passes, patient
      satisfaction during catheter placement, and morphine consumption compared with
      nerve stimulation guidance.
CI  - Copyright (c) 2011 by American Society of Regional Anesthesia and Pain Medicine
FAU - Bendtsen, Thomas F
AU  - Bendtsen TF
AD  - Department of Anesthesia and Intensive Care Medicine, Aarhus University Hospital,
      Aarhus, Denmark. tfb@dadlnet.dk
FAU - Nielsen, Thomas D
AU  - Nielsen TD
FAU - Rohde, Claus V
AU  - Rohde CV
FAU - Kibak, Kristian
AU  - Kibak K
FAU - Linde, Frank
AU  - Linde F
LA  - eng
SI  - ClinicalTrials.gov/NCT00497276
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Reg Anesth Pain Med
JT  - Regional anesthesia and pain medicine
JID - 9804508
SB  - IM
CIN - Reg Anesth Pain Med. 2011 Jul-Aug;36(4):414-5. PMID: 21697695
MH  - Adult
MH  - Aged
MH  - Elective Surgical Procedures/adverse effects/methods
MH  - Electric Stimulation/methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Block/*methods
MH  - Pain, Postoperative/etiology/prevention & control
MH  - *Sciatic Nerve/physiology
MH  - Ultrasonography, Interventional/*methods
EDAT- 2011/03/23 06:00
MHDA- 2011/12/24 06:00
CRDT- 2011/03/23 06:00
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2011/12/24 06:00 [medline]
AID - 10.1097/aap.0b013e31820d421f [doi]
PST - ppublish
SO  - Reg Anesth Pain Med. 2011 Mar-Apr;36(2):181-4. doi: 10.1097/aap.0b013e31820d421f.


PMID- 21425513
OWN - NLM
STAT- MEDLINE
DCOM- 20111223
LR  - 20191112
IS  - 1532-8651 (Electronic)
IS  - 1098-7339 (Linking)
VI  - 36
IP  - 2
DP  - 2011 Mar-Apr
TI  - A review of the benefits and pitfalls of phantoms in ultrasound-guided regional
      anesthesia.
PG  - 162-70
AB  - With the growth of ultrasound-guided regional anesthesia, so has the requirement 
      for training tools to practice needle guidance skills and evaluate echogenic
      needles. Ethically, skills in ultrasound-guided needle placement should be gained
      in a phantom before performance of nerve blocks on patients in clinical practice.
      However, phantom technology is varied, and critical evaluation of the images is
      needed to understand their application to clinical use. Needle visibility depends
      on the echogenicity of the needle relative to the echogenicity of the tissue
      adjacent the needle. We demonstrate this point using images of echogenic and
      nonechogenic needles in 5 different phantoms at both shallow angles (20 degrees) 
      and steep angles (45 degrees). The echogenicity of phantoms varies enormously,
      and this impacts on how needles are visualized. Water is anechoic, making all
      needles highly visible, but does not fix the needle to allow practice placement. 
      Gelatin phantoms and Blue Phantoms provide tactile feedback but have very low
      background echogenicity, which greatly exaggerates needle visibility. This makes 
      skill acquisition easier but can lead to false confidence in regard to clinical
      ability. Fresh-frozen cadavers retain much of the textural feel of live human
      tissue and are nearly as echogenic. Similar to clinical practice, this makes
      needles inserted at steep angles practically invisible, unless they are highly
      echogenic. This review describes the uses and pitfalls of phantoms that have been
      described or commercially produced.
CI  - Copyright (c) 2011 by American Society of Regional Anesthesia and Pain Medicine
FAU - Hocking, Graham
AU  - Hocking G
AD  - School of Medicine and Pharmacology, The University of Western Australia, Perth, 
      Western Australia. graham.hocking@anaesthesia.uwa.edu.au
FAU - Hebard, Simon
AU  - Hebard S
FAU - Mitchell, Christopher H
AU  - Mitchell CH
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Reg Anesth Pain Med
JT  - Regional anesthesia and pain medicine
JID - 9804508
SB  - IM
MH  - Anesthesia, Conduction/*instrumentation/*methods
MH  - Animals
MH  - Humans
MH  - Nerve Block/instrumentation/methods
MH  - *Phantoms, Imaging
MH  - Ultrasonography, Interventional/*instrumentation/*methods
EDAT- 2011/03/23 06:00
MHDA- 2011/12/24 06:00
CRDT- 2011/03/23 06:00
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2011/12/24 06:00 [medline]
AID - 10.1097/aap.0b013e31820d4207 [doi]
PST - ppublish
SO  - Reg Anesth Pain Med. 2011 Mar-Apr;36(2):162-70. doi:
      10.1097/aap.0b013e31820d4207.


PMID- 21425498
OWN - NLM
STAT- MEDLINE
DCOM- 20110425
LR  - 20110321
IS  - 1660-9379 (Print)
IS  - 1660-9379 (Linking)
VI  - 7
IP  - 282
DP  - 2011 Feb 16
TI  - [Ethics in medicine and elsewhere].
PG  - 418-9
FAU - Martin, Jean
AU  - Martin J
AD  - jean.martin@urbanet.ch
LA  - fre
PT  - Journal Article
TT  - Ethique, en medecine et ailleurs.
PL  - Switzerland
TA  - Rev Med Suisse
JT  - Revue medicale suisse
JID - 101219148
SB  - IM
MH  - *Bioethics
MH  - Down Syndrome/diagnosis
MH  - Early Diagnosis
MH  - Humans
MH  - Journalism, Medical
MH  - Patient Rights/*ethics/legislation & jurisprudence
MH  - Societies, Medical
MH  - Switzerland
MH  - Vietnam Conflict
MH  - World War II
EDAT- 2011/03/23 06:00
MHDA- 2011/04/26 06:00
CRDT- 2011/03/23 06:00
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2011/04/26 06:00 [medline]
PST - ppublish
SO  - Rev Med Suisse. 2011 Feb 16;7(282):418-9.


PMID- 21425414
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20191210
IS  - 1549-4918 (Electronic)
IS  - 1066-5099 (Linking)
VI  - 29
IP  - 3
DP  - 2011 Mar
TI  - Production of mouse embryonic stem cell lines from maturing oocytes by direct
      conversion of meiosis into mitosis.
PG  - 517-27
LID - 10.1002/stem.585 [doi]
AB  - ESCs are most commonly derived from embryos originating from oocytes that reached
      metaphase II. We describe here a novel approach where ESCs with all pluripotency 
      parameters were established from oocytes in which metaphase I was converted, from
      the cell cycle perspective, directly into metaphase II-like stage without the
      intervening anaphase to telophase I transition. The resulting embryos initiate
      development and reach the blastocyst stage from which the ESC lines are then
      established. Thus, our approach could represent an ethically acceptable method
      that can exploit oocytes that are typically discarded in in vitro fertilization
      clinics. Moreover, our results also indicate that the meiotic cell cycle can be
      converted into mitosis by modulating chromosomal contacts that are typical for
      meiosis with subsequent licensing of chromatin for DNA replication.
CI  - Copyright (c) 2011 AlphaMed Press.
FAU - Fulka, Helena
AU  - Fulka H
AD  - Department of Biology of Reproduction, Institute of Animal Science, Prague, Czech
      Republic.
FAU - Hirose, Michiko
AU  - Hirose M
FAU - Inoue, Kimiko
AU  - Inoue K
FAU - Ogonuki, Narumi
AU  - Ogonuki N
FAU - Wakisaka, Noriko
AU  - Wakisaka N
FAU - Matoba, Shogo
AU  - Matoba S
FAU - Ogura, Atsuo
AU  - Ogura A
FAU - Mosko, Tibor
AU  - Mosko T
FAU - Kott, Tomas
AU  - Kott T
FAU - Fulka, Josef Jr
AU  - Fulka J Jr
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Stem Cells
JT  - Stem cells (Dayton, Ohio)
JID - 9304532
SB  - IM
MH  - Animals
MH  - Cell Culture Techniques/methods
MH  - Cell Differentiation/physiology
MH  - Cell Line
MH  - Embryonic Stem Cells/*cytology/*physiology
MH  - Female
MH  - Male
MH  - Meiosis/*physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred DBA
MH  - Mitosis/genetics/*physiology
MH  - Oocytes/*cytology/physiology
MH  - Oogenesis/physiology
MH  - Parthenogenesis/physiology
MH  - Pregnancy
EDAT- 2011/03/23 06:00
MHDA- 2011/07/27 06:00
CRDT- 2011/03/23 06:00
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
AID - 10.1002/stem.585 [doi]
PST - ppublish
SO  - Stem Cells. 2011 Mar;29(3):517-27. doi: 10.1002/stem.585.


PMID- 21425401
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20211203
IS  - 1549-4918 (Electronic)
IS  - 1066-5099 (Linking)
VI  - 29
IP  - 3
DP  - 2011 Mar
TI  - Law, ethics, religion, and clinical translation in the 21st century--a
      conversation with Anthony D. Ho. Interview by Majlinda Lako, Alan O. Trounson,
      and Susan Daher.
PG  - 387-8
LID - 10.1002/stem.601 [doi]
FAU - Ho, Anthony D
AU  - Ho AD
LA  - eng
PT  - Historical Article
PT  - Interview
PT  - Portrait
PL  - England
TA  - Stem Cells
JT  - Stem cells (Dayton, Ohio)
JID - 9304532
SB  - IM
MH  - Cell Differentiation/physiology
MH  - Cell Proliferation
MH  - History, 21st Century
MH  - Humans
MH  - Molecular Biology/methods/trends
MH  - Pluripotent Stem Cells/cytology/physiology
MH  - *Religion and Science
MH  - Stem Cell Research/*ethics/*legislation & jurisprudence
MH  - Translational Research, Biomedical/ethics/*history/legislation &
      jurisprudence/*trends
EDAT- 2011/03/23 06:00
MHDA- 2011/07/27 06:00
CRDT- 2011/03/23 06:00
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
AID - 10.1002/stem.601 [doi]
PST - ppublish
SO  - Stem Cells. 2011 Mar;29(3):387-8. doi: 10.1002/stem.601.


PMID- 21425046
OWN - NLM
STAT- MEDLINE
DCOM- 20110815
LR  - 20191210
IS  - 1438-9592 (Electronic)
IS  - 0044-409X (Linking)
VI  - 136
IP  - 2
DP  - 2011 Apr
TI  - [Ethical conflicts in the surgical intensive care setting - impact of ethics
      consultations].
PG  - 113-7
LID - 10.1055/s-0031-1271398 [doi]
AB  - INTRODUCTION: In surgical intensive care medicine an increase in ethical
      conflicts regarding treatment plans has been observed due to marked changes in
      medical possibilities and social epidemiology resulting in intensive care
      treatment of old and oldest patients following surgery, trauma or
      transplantation. Without ethical support, physicians, nurses, and families are
      not able to come to a decision about medical treatment when value conflicts are
      involved. METHODS: We present a report on the basis of medical ethics and
      personal experience and provide an overview on the impact of ethics
      consultations. RESULTS: Ethical conflicts are common in the surgical intensive
      care setting, since the patient's preferences often are not known exactly, and in
      modern "high-tech" intensive care medicine the prognosis of recovery and / or
      quality of life of (old) patients seems to be hard to assess. Ethical definitions
      of treatment perspectives will find an important and increasing place in
      intensive care competence in the future, although nowadays there is a lack of
      theoretical and practical instruction in ethics. The goal of ethics consultations
      is to help physicians, nurses and family members by structuring the problem and
      by a moderation of discussion and problem resolution including a special "ethical
      workflow". Ethics consultations seem to be useful in resolving conflicts that may
      inappropriately prolong unwanted treatments. CONCLUSIONS: The incidence of
      ethical conflicts increases even in surgical intensive care units and ethics
      consultations may help in the integration of ethics principles in clinical
      practice.
CI  - (c) Georg Thieme Verlag KG Stuttgart New York.
FAU - Bein, T
AU  - Bein T
AD  - Universitatsklinik, Operative Intensivmedizin, Regensburg, Deutschland.
      thomas.bein@klinik.uni-regensburg.de
LA  - ger
PT  - Case Reports
PT  - Journal Article
PT  - Review
TT  - Ethische Grenzsituationen in der chirurgischen Intensivmedizin - Bedeutung einer 
      ethischen Fallberatung.
DEP - 20110321
PL  - Germany
TA  - Zentralbl Chir
JT  - Zentralblatt fur Chirurgie
JID - 0413645
SB  - IM
MH  - Aged, 80 and over
MH  - *Conflict, Psychological
MH  - *Cooperative Behavior
MH  - Critical Care/*ethics
MH  - Ethics Consultation/ethics
MH  - *Ethics, Medical
MH  - Humans
MH  - *Interdisciplinary Communication
MH  - Life Support Care/ethics
MH  - Male
MH  - Medical Futility/ethics
MH  - Pancreatic Neoplasms/therapy
MH  - Prognosis
MH  - Quality of Life
MH  - Renal Replacement Therapy/ethics
MH  - Ventilator Weaning/ethics
MH  - Withholding Treatment/ethics
EDAT- 2011/03/23 06:00
MHDA- 2011/08/16 06:00
CRDT- 2011/03/23 06:00
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2011/08/16 06:00 [medline]
AID - 10.1055/s-0031-1271398 [doi]
PST - ppublish
SO  - Zentralbl Chir. 2011 Apr;136(2):113-7. doi: 10.1055/s-0031-1271398. Epub 2011 Mar
      21.


PMID- 21424778
OWN - NLM
STAT- MEDLINE
DCOM- 20110819
LR  - 20211020
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 23
IP  - 1
DP  - 2011 Mar
TI  - Report of an international conference on the medical and ethical management of
      the neonate at the edge of viability: a review of approaches from five countries.
PG  - 31-42
LID - 10.1007/s10730-011-9149-6 [doi]
AB  - Current United States guidelines for neonatal resuscitation note that there is no
      mandate to resuscitate infants in all situations. For example, the fetus that at 
      the time of delivery is determined to be so premature as to be non-viable need
      not be aggressively resuscitated. The hypothetical case of an extremely premature
      infant was presented to neonatologists from the United States and four other
      European countries at a September 2006 international meeting sponsored by the
      World Health Organization Collaborating Center in Reproductive Health of Atlanta 
      (currently, the Global Collaborating Center in Reproductive Health). Responses to
      the case varied by country, due to differences in legal, ethical and related
      practice parameters, rather than differences in medical technology, as similar
      medical technology was available within each country. Variations in approach
      seemed to stem from physicians' perceptions of their ability to remove the
      neonate from life support if this appeared non-beneficial. There appears to be a 
      desire for greater convergence in practice options and more open discussion
      regarding the practical problems underlying the variability. Specifically, the
      conference attendees identified four areas that need to be addressed: (1) lack of
      international consensus guidelines in viability and therapeutic options, (2) lack
      of bodies capable of generating these guidelines, (3) variation in laws between
      countries, and (4) the frequent failure of physicians and families to confront
      death at the beginning of life.
FAU - Sexson, William R
AU  - Sexson WR
AD  - Emory University School of Medicine, Atlanta, GA 30303, USA. wsexson@emory.edu
FAU - Cruze, Deborah K
AU  - Cruze DK
FAU - Escobedo, Marilyn B
AU  - Escobedo MB
FAU - Brann, Alfred W
AU  - Brann AW
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - Concept Formation
MH  - *Congresses as Topic
MH  - Europe
MH  - Humans
MH  - Infant, Newborn
MH  - *Infant, Premature
MH  - Intensive Care, Neonatal/*ethics
MH  - Resuscitation/*ethics
MH  - Russia
MH  - United States
EDAT- 2011/03/23 06:00
MHDA- 2011/08/20 06:00
CRDT- 2011/03/23 06:00
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2011/08/20 06:00 [medline]
AID - 10.1007/s10730-011-9149-6 [doi]
PST - ppublish
SO  - HEC Forum. 2011 Mar;23(1):31-42. doi: 10.1007/s10730-011-9149-6.


PMID- 21424518
OWN - NLM
STAT- MEDLINE
DCOM- 20110926
LR  - 20211020
IS  - 1432-1971 (Electronic)
IS  - 0172-0643 (Linking)
VI  - 32
IP  - 5
DP  - 2011 Jun
TI  - Clinical experience with Berlin Heart Excor in pediatric patients in Argentina:
      1373 days of cardiac support.
PG  - 652-8
LID - 10.1007/s00246-011-9949-0 [doi]
AB  - The objective of this study was to describe our experience (1373 days of support)
      with the Berlin Heart Excor (BH) ventricular-assist device (VAD) as bridging to
      cardiac transplantation in pediatric patients with end-stage cardiomyopathy. This
      study involved a retrospective observational cohort. Records of patients
      supported with the BH VAD were reviewed. Data regarding age, sex, weight,
      diagnosis, preoperative condition, single versus biventricular support,
      morbidity, and mortality were collected. Criteria for single versus biventricular
      support and intensive care unit management were registered. The procedure was
      approved by our Institutional Ethics Committee, and informed consent was
      obtained. Between March 2006 and March 2010, 12 patients with diagnosis of
      dilated (n = 10) and restrictive (n = 2) cardiomyopathy were supported. Median
      age was 56.6 months (range 20.1-165.9); mean weight was 18.3 kg (range 8.5-45);
      and nine patients were female. Every patient presented with severe heart failure 
      refractory to pharmacological therapy. Biventricular support was necessary in
      four patients. Nine patients underwent heart transplantation. No child was weaned
      off the BH VAD because of myocardial recovery. Mean length of support was 73 days
      (range 3-331), and the total number of days of support was 1373. Three patients
      had fatal complications: 2 had thrombo-hemorrhagic stroke leading to brain death,
      and one had refractory vasoplegic shock. The BH VAD is a useful and reasonable
      safe device for cardiac transplantation bridging in children with end-stage heart
      failure. Team experience resulted in less morbidity and mortality, and time for
      implantation, surgical procedure, anticoagulation monitoring, and patient care
      improved.
FAU - Moreno, Guillermo E
AU  - Moreno GE
AD  - Cardiac Intensive Care Unit, Hospital de Pediatria "Dr. Juan P. Garrahan", Buenos
      Aires, Argentina. guillermo.moreno1@gmail.com
FAU - Charroqui, Alberto
AU  - Charroqui A
FAU - Pilan, Maria L
AU  - Pilan ML
FAU - Magliola, Ricardo H
AU  - Magliola RH
FAU - Krynski, Mariela P
AU  - Krynski MP
FAU - Althabe, Maria
AU  - Althabe M
FAU - Landry, Luis M
AU  - Landry LM
FAU - Sciuccati, Gabriela
AU  - Sciuccati G
FAU - Villa, Alejandra
AU  - Villa A
FAU - Vogelfang, Horacio
AU  - Vogelfang H
LA  - eng
PT  - Journal Article
DEP - 20110320
PL  - United States
TA  - Pediatr Cardiol
JT  - Pediatric cardiology
JID - 8003849
SB  - IM
MH  - Adolescent
MH  - Argentina
MH  - Cardiomyopathy, Dilated/mortality/*surgery
MH  - Cardiomyopathy, Restrictive/mortality/*surgery
MH  - Cause of Death
MH  - Child
MH  - Child, Preschool
MH  - *Cross-Cultural Comparison
MH  - Female
MH  - Heart Failure/mortality/surgery
MH  - *Heart Transplantation/mortality
MH  - *Heart-Assist Devices
MH  - Hospital Mortality
MH  - Humans
MH  - Infant
MH  - Intensive Care Units, Pediatric
MH  - Male
MH  - Postoperative Complications/mortality/surgery
MH  - Prosthesis Design
MH  - Retrospective Studies
MH  - Survival Rate
EDAT- 2011/03/23 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/03/23 06:00
PHST- 2010/12/03 00:00 [received]
PHST- 2011/02/24 00:00 [accepted]
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 10.1007/s00246-011-9949-0 [doi]
PST - ppublish
SO  - Pediatr Cardiol. 2011 Jun;32(5):652-8. doi: 10.1007/s00246-011-9949-0. Epub 2011 
      Mar 20.


PMID- 21424292
OWN - NLM
STAT- MEDLINE
DCOM- 20110815
LR  - 20211020
IS  - 1433-0385 (Electronic)
IS  - 0009-4722 (Linking)
VI  - 82
IP  - 4
DP  - 2011 Apr
TI  - [Cell sources for cardiovascular tissue engineering].
PG  - 295-302
LID - 10.1007/s00104-010-2030-3 [doi]
AB  - Numerous studies have confirmed that stem cell therapy has significant potential 
      for the regeneration of congenital and acquired heart diseases. The utilization
      of embryonic stem cells and induced pluripotent stem cells promises a possible
      generation and regeneration of all cardiovascular structures. On the one hand
      fetal and adult stem cells, e.g. endothelial progenitors, mesenchymal,
      hematopoietic, cardiac stem cells and myoblasts, possess limited potential for
      multilinear differentiation. On the other hand these cells have high paracrin
      activity and support with well-confirmed safety the reconstruction and formation 
      of cardiovascular structures. On the visionary track towards an autonomously
      functioning autologous heart generated by tissue engineering, vascular, valvular 
      and myocardial tissues have already been successfully created. This manuscript
      describes the possible stem cell sources for cardiovascular tissue engineering
      and evaluates their potency and safety from a medical and ethical point of view
      employing the data from systematic reviews (Medline database) and own
      investigations.
FAU - Klopsch, C
AU  - Klopsch C
AD  - Referenz- und Translationszentrum fur kardiale Stammzelltherapie, Universitat
      Rostock, Rostock, Germany.
FAU - Donndorf, P
AU  - Donndorf P
FAU - Kaminski, A
AU  - Kaminski A
FAU - Ma, N
AU  - Ma N
FAU - Steinhoff, G
AU  - Steinhoff G
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Zellquellen fur kardiovaskulares Tissue Engineering.
PL  - Germany
TA  - Chirurg
JT  - Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
JID - 16140410R
SB  - IM
MH  - Animals
MH  - Cardiovascular Diseases/*surgery
MH  - Cell Differentiation/physiology
MH  - Embryonic Stem Cells/cytology/transplantation
MH  - Ethics, Medical
MH  - Ethics, Research
MH  - Guided Tissue Regeneration/ethics/methods
MH  - Humans
MH  - Multipotent Stem Cells/cytology/transplantation
MH  - Pluripotent Stem Cells/cytology/transplantation
MH  - Stem Cell Transplantation/methods
MH  - Tissue Engineering/ethics/*methods
MH  - Totipotent Stem Cells/cytology/transplantation
EDAT- 2011/03/23 06:00
MHDA- 2011/08/16 06:00
CRDT- 2011/03/23 06:00
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2011/08/16 06:00 [medline]
AID - 10.1007/s00104-010-2030-3 [doi]
PST - ppublish
SO  - Chirurg. 2011 Apr;82(4):295-302. doi: 10.1007/s00104-010-2030-3.


PMID- 21424235
OWN - NLM
STAT- MEDLINE
DCOM- 20120316
LR  - 20211203
IS  - 2629-3277 (Electronic)
IS  - 2629-3277 (Linking)
VI  - 7
IP  - 4
DP  - 2011 Nov
TI  - Variation in mesodermal and hematopoietic potential of adult skin-derived induced
      pluripotent stem cell lines in mice.
PG  - 958-68
LID - 10.1007/s12015-011-9249-3 [doi]
AB  - Induced pluripotent stem cells (iPSCs) are a promising tool for regenerative
      medicine. Use of iPSC lines for future hematotherapy will require examination of 
      their hematopoietic potential. Adult skin fibroblast somatic cells constitute a
      source of iPSCs that can be accessed clinically without ethical issues. Here, we 
      used different methods to compare mesodermal and hematopoietic potential by
      embryoid body formation of five iPSC lines established from adult mouse tail-tip 
      fibroblasts (TTFs). We observed variation in proliferation and in expression of
      genes (Brachyury, Tbx1, Gata1, Klf1, Csf1r) and proteins (Flk1, Ter119 and CD45) 
      among TTF-derived lines. 256H18 iPSCs showed highest proliferation and most
      efficient differentiation into mesodermal and hematopoietic cells, while
      expression levels of the pluripotency genes Oct3/4, Sox2, Klf4 and Nanog were
      lowest among lines analyzed. By contrast, the 212B2 line, transduced with c-Myc, 
      showed lowest proliferation and differentiation potential, although expression
      levels of Oct3/4, Sox2 and Klf4 were highest. Overall, we find that mesodermal
      and hematopoietic potential varies among iPSCs from an identical tissue source
      and that c-Myc expression likely underlies these differences.
FAU - Inoue, Tomoko
AU  - Inoue T
AD  - Department of Hematopoietic Stem Cells, SSP Stem Cell Unit, Kyushu University
      Faculty of Medical Sciences, Station for Collaborative Research 1 4F, 3-1-1
      Maidashi, Higashi-Ku, Fukuoka 812-8582, Japan.
FAU - Kulkeaw, Kasem
AU  - Kulkeaw K
FAU - Okayama, Satoko
AU  - Okayama S
FAU - Tani, Kenzaburo
AU  - Tani K
FAU - Sugiyama, Daisuke
AU  - Sugiyama D
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Stem Cell Rev Rep
JT  - Stem cell reviews and reports
JID - 101752767
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Klf4 protein, mouse)
RN  - 0 (Kruppel-Like Factor 4)
RN  - 0 (Myc protein, mouse)
RN  - 0 (Nanog Homeobox Protein)
RN  - 0 (Nanog protein, mouse)
RN  - 0 (Proto-Oncogene Proteins c-myc)
RN  - 0 (T-Box Domain Proteins)
RN  - 0 (Tbx1 protein, mouse)
SB  - IM
MH  - Animals
MH  - Cell Count
MH  - Cell Culture Techniques
MH  - *Cell Differentiation
MH  - Cell Line
MH  - Cell Proliferation
MH  - Embryoid Bodies/cytology/metabolism
MH  - Fibroblasts/cytology/metabolism
MH  - Gene Expression Regulation
MH  - Hematopoietic Stem Cells/*cytology/metabolism
MH  - Homeodomain Proteins/genetics/metabolism
MH  - Induced Pluripotent Stem Cells/*cytology/metabolism
MH  - Kruppel-Like Factor 4
MH  - Mesoderm/*cytology/metabolism
MH  - Mice
MH  - Nanog Homeobox Protein
MH  - Proto-Oncogene Proteins c-myc/genetics/metabolism
MH  - Retroviridae/genetics/metabolism
MH  - Skin/cytology
MH  - T-Box Domain Proteins/genetics/metabolism
MH  - Transfection
EDAT- 2011/03/23 06:00
MHDA- 2012/03/17 06:00
CRDT- 2011/03/23 06:00
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2012/03/17 06:00 [medline]
AID - 10.1007/s12015-011-9249-3 [doi]
PST - ppublish
SO  - Stem Cell Rev Rep. 2011 Nov;7(4):958-68. doi: 10.1007/s12015-011-9249-3.


PMID- 21424171
OWN - NLM
STAT- MEDLINE
DCOM- 20110805
LR  - 20110331
IS  - 1432-5241 (Electronic)
IS  - 0364-216X (Linking)
VI  - 35
IP  - 2
DP  - 2011 Apr
TI  - Which principles? : commentary on "Ethical issues in plastic and reconstructive
      surgery".
PG  - 268-9
LID - 10.1007/s00266-011-9693-0 [doi]
FAU - Bognar, Greg
AU  - Bognar G
AD  - Center for Bioethics, New York University, NY 10003, USA. Greg.bognar@nyu.edu
LA  - eng
PT  - Comment
PT  - Journal Article
DEP - 20110318
PL  - United States
TA  - Aesthetic Plast Surg
JT  - Aesthetic plastic surgery
JID - 7701756
SB  - IM
CON - Aesthetic Plast Surg. 2011 Apr;35(2):262-7. PMID: 21336881
MH  - Attitude of Health Personnel
MH  - Beneficence
MH  - Female
MH  - Humans
MH  - Male
MH  - Personal Autonomy
MH  - Physician-Patient Relations
MH  - *Principle-Based Ethics
MH  - Quality Control
MH  - Reconstructive Surgical Procedures/*ethics/methods
MH  - Surgery, Plastic/*ethics/methods
EDAT- 2011/03/23 06:00
MHDA- 2011/08/06 06:00
CRDT- 2011/03/23 06:00
PHST- 2011/02/17 00:00 [received]
PHST- 2011/02/17 00:00 [accepted]
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2011/08/06 06:00 [medline]
AID - 10.1007/s00266-011-9693-0 [doi]
PST - ppublish
SO  - Aesthetic Plast Surg. 2011 Apr;35(2):268-9. doi: 10.1007/s00266-011-9693-0. Epub 
      2011 Mar 18.


PMID- 21423584
OWN - NLM
STAT- MEDLINE
DCOM- 20110729
LR  - 20211020
IS  - 1549-1676 (Electronic)
IS  - 1549-1277 (Linking)
VI  - 8
IP  - 3
DP  - 2011 Mar
TI  - The challenge of discharging research ethics duties in resource-constrained
      settings.
PG  - e1000421
LID - 10.1371/journal.pmed.1000421 [doi]
FAU - Singh, Jerome Amir
AU  - Singh JA
AD  - Centre for the AIDS Programme of Research in South Africa (CAPRISA), University
      of Kwazulu-Natal, Durban, South Africa. singhj9@ukzn.ac.za
LA  - eng
PT  - Comment
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110315
PL  - United States
TA  - PLoS Med
JT  - PLoS medicine
JID - 101231360
RN  - 0 (Antitubercular Agents)
SB  - IM
CON - PLoS Med. 2011 Mar;8(3):e1000427. PMID: 21423586
MH  - Antitubercular Agents/standards/*therapeutic use
MH  - Cohort Studies
MH  - Developing Countries
MH  - *Ethics, Research
MH  - Humans
MH  - Prospective Studies
MH  - Randomized Controlled Trials as Topic
MH  - Retreatment
MH  - Treatment Outcome
MH  - Tuberculosis, Multidrug-Resistant/*drug therapy
MH  - Tuberculosis, Pulmonary/*drug therapy
MH  - Uganda/epidemiology
PMC - PMC3058061
EDAT- 2011/03/23 06:00
MHDA- 2011/07/30 06:00
CRDT- 2011/03/23 06:00
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2011/07/30 06:00 [medline]
AID - 10.1371/journal.pmed.1000421 [doi]
PST - ppublish
SO  - PLoS Med. 2011 Mar;8(3):e1000421. doi: 10.1371/journal.pmed.1000421. Epub 2011
      Mar 15.


PMID- 21423344
OWN - NLM
STAT- MEDLINE
DCOM- 20110729
LR  - 20211020
IS  - 1549-1676 (Electronic)
IS  - 1549-1277 (Linking)
VI  - 8
IP  - 3
DP  - 2011 Mar
TI  - Predicting harms and benefits in translational trials: ethics, evidence, and
      uncertainty.
PG  - e1001010
LID - 10.1371/journal.pmed.1001010 [doi]
FAU - Kimmelman, Jonathan
AU  - Kimmelman J
AD  - Biomedical Ethics Unit, Department of Social Studies of Medicine, McGill
      University, Montreal, Quebec, Canada.
FAU - London, Alex John
AU  - London AJ
LA  - eng
GR  - EOG 102823/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110308
PL  - United States
TA  - PLoS Med
JT  - PLoS medicine
JID - 101231360
SB  - IM
CIN - PLoS Med. 2011 Mar;8(3):e1001011. PMID: 21423343
MH  - Clinical Trials as Topic/*ethics
MH  - *Drug Evaluation, Preclinical
MH  - Eligibility Determination
MH  - *Ethics, Research
MH  - *Evidence-Based Practice
MH  - Forecasting
MH  - Humans
MH  - Reproducibility of Results
MH  - Risk Assessment
MH  - *Uncertainty
PMC - PMC3050916
EDAT- 2011/03/23 06:00
MHDA- 2011/07/30 06:00
CRDT- 2011/03/23 06:00
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2011/07/30 06:00 [medline]
AID - 10.1371/journal.pmed.1001010 [doi]
PST - ppublish
SO  - PLoS Med. 2011 Mar;8(3):e1001010. doi: 10.1371/journal.pmed.1001010. Epub 2011
      Mar 8.


PMID- 21423060
OWN - NLM
STAT- MEDLINE
DCOM- 20151117
LR  - 20191210
IS  - 1539-0683 (Electronic)
IS  - 0361-929X (Linking)
VI  - 36
IP  - 3
DP  - 2011 May-Jun
TI  - An overview of ethics in maternal-child nursing.
PG  - 154-9; quiz 160-1
LID - 10.1097/NMC.0b013e3182102175 [doi]
AB  - Ethical issues across the childbearing year are multiple and complex. This
      article addresses ethical challenges facing maternal-child nurses and identifies 
      strategies for making ethical decisions utilizing ethical principles and
      frameworks. Coping strategies for dealing with moral distress, how nurses
      demonstrate moral courage, and the attributes of an effective ethical decision
      maker are described. Ethical issues related to healthcare team relationships are 
      discussed, with implications for nurses provided.
FAU - Callister, Lynn Clark
AU  - Callister LC
AD  - Lynn Clark Callister is a Professor Emerita at Brigham Young University College
      of Nursing. She can be reached via e-mail at Lynn_callister@byu.edu Tanya
      Sudia-Robinson is a Professor at Georgia Baptist College of Nursing of Mercer
      University. She can be reached via e-mail at Robinson_ts@mercer.edu.
FAU - Sudia-Robinson, Tanya
AU  - Sudia-Robinson T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - MCN Am J Matern Child Nurs
JT  - MCN. The American journal of maternal child nursing
JID - 7605941
SB  - IM
MH  - *Adaptation, Psychological
MH  - Conflict, Psychological
MH  - *Decision Making
MH  - Education, Nursing, Continuing
MH  - *Ethics, Nursing
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - International Council of Nurses
MH  - Maternal-Child Nursing/*ethics
MH  - *Moral Obligations
MH  - Nurse's Role
MH  - Nurse-Patient Relations
MH  - Nursing Staff, Hospital/*ethics/*psychology
MH  - Pregnancy
MH  - Stress, Psychological
EDAT- 2011/03/23 06:00
MHDA- 2015/11/18 06:00
CRDT- 2011/03/23 06:00
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2015/11/18 06:00 [medline]
AID - 10.1097/NMC.0b013e3182102175 [doi]
PST - ppublish
SO  - MCN Am J Matern Child Nurs. 2011 May-Jun;36(3):154-9; quiz 160-1. doi:
      10.1097/NMC.0b013e3182102175.


PMID- 21422090
OWN - NLM
STAT- MEDLINE
DCOM- 20110531
LR  - 20220317
IS  - 1098-4275 (Electronic)
IS  - 0031-4005 (Linking)
VI  - 127
IP  - 4
DP  - 2011 Apr
TI  - Legal, ethical, and financial dilemmas in electronic health record adoption and
      use.
PG  - e1042-7
LID - 10.1542/peds.2010-2184 [doi]
AB  - Electronic health records (EHRs) facilitate several innovations capable of
      reforming health care. Despite their promise, many currently unanswered legal,
      ethical, and financial questions threaten the widespread adoption and use of
      EHRs. Key legal dilemmas that must be addressed in the near-term pertain to the
      extent of clinicians' responsibilities for reviewing the entire
      computer-accessible clinical synopsis from multiple clinicians and institutions, 
      the liabilities posed by overriding clinical decision support warnings and
      alerts, and mechanisms for clinicians to publically report potential EHR safety
      issues. Ethical dilemmas that need additional discussion relate to opt-out
      provisions that exclude patients from electronic record storage, sale of
      deidentified patient data by EHR vendors, adolescent control of access to their
      data, and use of electronic data repositories to redesign the nation's health
      care delivery and payment mechanisms on the basis of statistical analyses.
      Finally, one overwhelming financial question is who should pay for EHR
      implementation because most users and current owners of these systems will not
      receive the majority of benefits. The authors recommend that key stakeholders
      begin discussing these issues in a national forum. These actions can help
      identify and prioritize solutions to the key legal, ethical, and financial
      dilemmas discussed, so that widespread, safe, effective, interoperable EHRs can
      help transform health care.
FAU - Sittig, Dean F
AU  - Sittig DF
AD  - University of Texas Memorial Hermann Center for Healthcare Quality and Safety,
      University of Texas School of Biomedical Informatics at Houston, 6410 Fannin St, 
      UTPB 1100.43, Houston, TX 77030, USA. dean.f.sittig@uth.tmc.edu
FAU - Singh, Hardeep
AU  - Singh H
LA  - eng
GR  - ONC #10510592/PHS HHS/United States
GR  - R01-LM006942/LM/NLM NIH HHS/United States
GR  - K23CA125585/CA/NCI NIH HHS/United States
GR  - R01 LM006942/LM/NLM NIH HHS/United States
GR  - K23 CA125585/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20110321
PL  - United States
TA  - Pediatrics
JT  - Pediatrics
JID - 0376422
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Confidentiality/ethics/legislation & jurisprudence
MH  - Decision Support Techniques
MH  - Electronic Health Records/economics/*ethics/*legislation & jurisprudence
MH  - *Ethics, Medical
MH  - Financial Support/ethics
MH  - Health Care Reform/economics/ethics/legislation & jurisprudence
MH  - Health Plan Implementation/economics
MH  - Humans
MH  - Infant
MH  - Liability, Legal
MH  - Physician's Role
MH  - Safety Management
MH  - United States
PMC - PMC3065078
EDAT- 2011/03/23 06:00
MHDA- 2011/06/01 06:00
CRDT- 2011/03/23 06:00
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2011/06/01 06:00 [medline]
AID - peds.2010-2184 [pii]
AID - 10.1542/peds.2010-2184 [doi]
PST - ppublish
SO  - Pediatrics. 2011 Apr;127(4):e1042-7. doi: 10.1542/peds.2010-2184. Epub 2011 Mar
      21.


PMID- 21421205
OWN - NLM
STAT- MEDLINE
DCOM- 20110803
LR  - 20190117
IS  - 1728-7731 (Electronic)
IS  - 1726-4901 (Linking)
VI  - 74
IP  - 3
DP  - 2011 Mar
TI  - Performance of European system for cardiac operative risk evaluation in Veterans 
      General Hospital Kaohsiung cardiac surgery.
PG  - 115-20
LID - 10.1016/j.jcma.2011.01.025 [doi]
AB  - BACKGROUND: The European System for Cardiac Operative Risk Evaluation (EuroSCORE)
      model is a widely-used risk prediction algorithm for in-hospital or 30-day
      mortality in adult cardiac surgery patients. Recent studies indicated that
      EuroSCORE tends to overpredict mortality. The aim of our study is to evaluate the
      validity of EuroSCORE in Veterans General Hospital Kaohsiung (VGHKS) cardiac
      surgery including a number of different surgical and risk subgroups. METHODS:
      From January 2006 to December 2009, 1,240 adult patients who underwent cardiac
      surgery in VGHKS were included in this study. The study was followed the
      guidelines of the Ethics Committee of Kaohsiung Veterans General Hospital,
      Taiwan. Both additive and logistic score of all patients were calculated
      depending on the formula in the official EuroSCORE website. The entire cohort,
      different surgical type and risk stratification subgroups were analyzed. Model
      discrimination was tested by determining the area under receiver operating
      characteristic (ROC) curve. Model calibration was tested by the Hosmer-Lemeshow
      chi-square test. Clinical performance of model was assessed by comparing the
      observed and predicted mortality rates. RESULTS: There were significant
      differences between the VGHKS and European cardiac surgical populations. The
      additive score and logistic score for the overall group were 7.16% and 12.88%,
      respectively. Observed mortality was 10.72% overall, 5.68% for isolated coronary 
      artery bypass grafting (CABG), 4.67% for the mitral valve only and 4.25% for the 
      aortic valve only group. The discriminative ability EuroSCORE was very good in
      all and various surgical subgroups, with area under the ROC curve from 0.75 to
      0.87. The addictive and logistic models of EuroSCORE showed excellent accuracy,
      0.839 and 0.845, respectively. Good calibration power was recognized by p value
      higher than 0.05 for the entire cohort and all subgroups of patients except for
      isolated CABG. The logistic EuroSCORE model overestimated mortality to different 
      degrees in the various subgroups, indicating that the logistic EuroSCORE needs to
      be recalibrated by a factor about 0.55 for uncomplicated surgery and low-risk
      groups, and 0.85 for high-risk patients with original additive score more than
      six. CONCLUSION: EuroSCORE is simple and easy to use. In the present study, the
      model demonstrated excellent accuracy in all and various surgical subgroups in
      VGHKS cardiovascular surgery populations. Good calibration ability in all and
      different risk categories was identified except for isolated CABG group.
      Recalibration factors of 0.55 and 0.85 were suggested for the various operative
      subgroups and risk categories.
CI  - Copyright (c) 2011. Published by Elsevier B.V.
FAU - Shih, Hsin-Hung
AU  - Shih HH
AD  - Division of Cardiovascular Surgery, Kaohsiung Veterans General Hospital,
      Kaohsiung, Taiwan, ROC.
FAU - Kang, Pei-Luen
AU  - Kang PL
FAU - Pan, Jun-Yen
AU  - Pan JY
FAU - Wu, Tung-Ho
AU  - Wu TH
FAU - Wu, Chieh-Ten
AU  - Wu CT
FAU - Lin, Chun-Yao
AU  - Lin CY
FAU - Lin, Yu-Hsin
AU  - Lin YH
FAU - Chou, Wan-Ting
AU  - Chou WT
LA  - eng
PT  - Journal Article
DEP - 20110301
PL  - Netherlands
TA  - J Chin Med Assoc
JT  - Journal of the Chinese Medical Association : JCMA
JID - 101174817
SB  - IM
MH  - Aged
MH  - Cardiac Surgical Procedures/*mortality
MH  - Coronary Artery Bypass/mortality
MH  - Female
MH  - Hospital Mortality
MH  - Hospitals, Veterans
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - ROC Curve
MH  - Taiwan
EDAT- 2011/03/23 06:00
MHDA- 2011/08/04 06:00
CRDT- 2011/03/23 06:00
PHST- 2010/07/26 00:00 [received]
PHST- 2010/11/02 00:00 [accepted]
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
AID - S1726-4901(11)00027-X [pii]
AID - 10.1016/j.jcma.2011.01.025 [doi]
PST - ppublish
SO  - J Chin Med Assoc. 2011 Mar;74(3):115-20. doi: 10.1016/j.jcma.2011.01.025. Epub
      2011 Mar 1.


PMID- 21420909
OWN - NLM
STAT- MEDLINE
DCOM- 20120127
LR  - 20151119
IS  - 1525-5069 (Electronic)
IS  - 1525-5050 (Linking)
VI  - 22
IP  - 1
DP  - 2011 Sep
TI  - Newly diagnosed epilepsy and pharmacogenomics research: a step in the right
      direction?
PG  - 3-8
LID - 10.1016/j.yebeh.2011.02.012 [doi]
AB  - Pharmacogenomics holds the promise of selecting the right drug at the right dose 
      for the right person. Its research and application in epilepsy are in their
      infancy. Although advances have been made in identifying genetic markers of
      adverse effects in terms of severe cutaneous reactions, there has been little
      progress in predicting efficacy. Most studies have been retrospective and
      case-control in design, despite the associated problems of recall bias and a
      usually undefined relationship between genotype and outcome. We describe the
      epidemiological framework necessary to detect genetic influences on antiepileptic
      drug response, and propose an ambitious prospective outcome study of newly
      diagnosed epilepsy across all age ranges, countries, and continents, which would 
      provide the template for a global pharmacogenomic project. Other epidemiological 
      considerations and statistical constraints and issues related to study design,
      databases, and ethics that are critical for advancement in the field are also
      discussed.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Johnson, Michael R
AU  - Johnson MR
AD  - Centre for Neuroscience, Department of Medicine, Imperial College London, UK.
FAU - Tan, Nigel C K
AU  - Tan NC
FAU - Kwan, Patrick
AU  - Kwan P
FAU - Brodie, Martin J
AU  - Brodie MJ
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110321
PL  - United States
TA  - Epilepsy Behav
JT  - Epilepsy & behavior : E&B
JID - 100892858
SB  - IM
MH  - Biomedical Research/methods
MH  - Databases, Factual
MH  - Epilepsy/diagnosis/genetics/*therapy
MH  - Genetic Testing
MH  - Humans
MH  - Pharmacogenetics/*methods
MH  - *Precision Medicine
MH  - Predictive Value of Tests
EDAT- 2011/03/23 06:00
MHDA- 2012/01/28 06:00
CRDT- 2011/03/23 06:00
PHST- 2011/02/08 00:00 [received]
PHST- 2011/02/10 00:00 [accepted]
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2012/01/28 06:00 [medline]
AID - S1525-5050(11)00068-0 [pii]
AID - 10.1016/j.yebeh.2011.02.012 [doi]
PST - ppublish
SO  - Epilepsy Behav. 2011 Sep;22(1):3-8. doi: 10.1016/j.yebeh.2011.02.012. Epub 2011
      Mar 21.


PMID- 21420666
OWN - NLM
STAT- MEDLINE
DCOM- 20110901
LR  - 20110412
IS  - 1578-1860 (Electronic)
IS  - 0014-2565 (Linking)
VI  - 211
IP  - 4
DP  - 2011 Apr
TI  - [Nazism and medicine. Learning from history].
PG  - 199-203
LID - 10.1016/j.rce.2010.06.015 [doi]
AB  - Between 1933-1945 in Nazi Germany, physicians and other professional care
      providers participated in forced sterilization of patients who were carriers of
      genetic origin diseases and psychiatric disorders, extermination of children and 
      adults with congenital and mental diseases, "scientific and pseudoscientific"
      medical experiments without consent and mass extermination of people based on
      their religion, political, cultural or sexual identity (Jews, gypsies,
      homosexuals). At present, the same ethical issues present during Nazi Period
      (research limits, end-life decisions, role of the physician as state or health
      system servant, and genetic research) continue to be present in routine medical
      care. Having knowledge of the past and the role played by Nazi doctors reinforces
      the necessary emphasis on bioethics and professionalism within the training of
      professional health providers.
CI  - Copyright (c) 2010 Elsevier Espana, S.L. All rights reserved.
FAU - Gonzalez-Lopez, E
AU  - Gonzalez-Lopez E
AD  - Unidad de Medicina de Familia y Atencion Primaria, Departamento de Medicina,
      Centro de Salud Universitario Villanueva de la Canada, Universidad Autonoma de
      Madrid, Espana. estebangl@wanadoo.es
LA  - spa
PT  - English Abstract
PT  - Historical Article
PT  - Journal Article
TT  - Medicina y nazismo. Aprender de la historia.
DEP - 20110321
PL  - Spain
TA  - Rev Clin Esp
JT  - Revista clinica espanola
JID - 8608576
SB  - IM
MH  - Ethics, Medical/*history
MH  - Germany
MH  - *History of Medicine
MH  - History, 20th Century
MH  - National Socialism/*history
EDAT- 2011/03/23 06:00
MHDA- 2011/09/02 06:00
CRDT- 2011/03/23 06:00
PHST- 2010/06/13 00:00 [received]
PHST- 2010/06/21 00:00 [accepted]
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2011/09/02 06:00 [medline]
AID - S0014-2565(11)00054-3 [pii]
AID - 10.1016/j.rce.2010.06.015 [doi]
PST - ppublish
SO  - Rev Clin Esp. 2011 Apr;211(4):199-203. doi: 10.1016/j.rce.2010.06.015. Epub 2011 
      Mar 21.


PMID- 21420314
OWN - NLM
STAT- MEDLINE
DCOM- 20120224
LR  - 20220321
IS  - 1036-7314 (Print)
IS  - 1036-7314 (Linking)
VI  - 24
IP  - 4
DP  - 2011 Nov
TI  - Intensive Care Research Coordinators in Australia and New Zealand: a
      cross-sectional survey of demographics, responsibilities, job satisfaction and
      importance.
PG  - 259-68
LID - 10.1016/j.aucc.2011.02.003 [doi]
AB  - INTRODUCTION: The achievement of successful clinical research projects depends on
      multiple team members including Research Coordinators (RCs), who are the link
      between the researcher and the trial participants. The RCs main responsibility is
      to ensure that all research is conducted according to the appropriate protocols, 
      regulations and guidelines. AIM: Description of demographics, the role and
      associated responsibilities and assessment of items of importance to, and
      satisfaction with, various job related items. METHOD: An observational web-based 
      cross-sectional study of RCs working in Intensive Care Units (ICU) across
      Australia and New Zealand. RESULTS: Fifty-six participants completed the survey. 
      Forty percent had more than 6 years experience in ICU research and one-third held
      a Masters Degree. Most respondents performed research related tasks including
      ethics submission, patient screening, education and data collection. Autonomy and
      work hours were the most satisfying job characteristics reported and aspects
      relating to autonomy were most important for the RCs. Inadequate remuneration was
      of great concern to the participants. CONCLUSION: Research Coordinators in
      Australia and New Zealand have many and varied roles with a significant workload.
      Unfortunately, the RCs do not feel their employers are adequately remunerating
      the demand on their time and efforts. The results indicate that RCs enjoy high
      levels of satisfaction with general conditions and facets of their work and its
      environment and they remain passionate about their role in the ICU setting.
CI  - Crown Copyright (c) 2011. Published by Elsevier Ltd. All rights reserved.
FAU - Roberts, Brigit
AU  - Roberts B
AD  - Department of Intensive Care, Sir Charles Gairdner Hospital, Hospital Avenue,
      Nedlands, Perth, Western Australia 6009, Australia.
      Brigit.Roberts@health.wa.gov.au
FAU - Eastwood, Glenn M
AU  - Eastwood GM
FAU - Raunow, Heike
AU  - Raunow H
FAU - Howe, Belinda
AU  - Howe B
FAU - Rickard, Claire M
AU  - Rickard CM
LA  - eng
PT  - Journal Article
DEP - 20110321
PL  - Australia
TA  - Aust Crit Care
JT  - Australian critical care : official journal of the Confederation of Australian
      Critical Care Nurses
JID - 9207852
MH  - Adult
MH  - Australia
MH  - Critical Care/*organization & administration
MH  - Cross-Sectional Studies
MH  - Demography
MH  - Female
MH  - Humans
MH  - *Job Description
MH  - *Job Satisfaction
MH  - Male
MH  - Middle Aged
MH  - New Zealand
MH  - Professional Autonomy
MH  - *Research Personnel
MH  - Surveys and Questionnaires
EDAT- 2011/03/23 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/03/23 06:00
PHST- 2010/08/30 00:00 [received]
PHST- 2011/02/11 00:00 [revised]
PHST- 2011/02/22 00:00 [accepted]
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - S1036-7314(11)00049-X [pii]
AID - 10.1016/j.aucc.2011.02.003 [doi]
PST - ppublish
SO  - Aust Crit Care. 2011 Nov;24(4):259-68. doi: 10.1016/j.aucc.2011.02.003. Epub 2011
      Mar 21.


PMID- 21420209
OWN - NLM
STAT- MEDLINE
DCOM- 20110908
LR  - 20191210
IS  - 1879-1700 (Electronic)
IS  - 0265-931X (Linking)
VI  - 102
IP  - 6
DP  - 2011 Jun
TI  - Human bones obtained from routine joint replacement surgery as a tool for studies
      of plutonium, americium and (9)(0)Sr body-burden in general public.
PG  - 559-65
LID - 10.1016/j.jenvrad.2011.02.013 [doi]
AB  - The paper presents a new sampling method for studying in-body radioactive
      contamination by bone-seeking radionuclides such as (90)Sr, (239+240)Pu, (238)Pu,
      (241)Am and selected gamma-emitters, in human bones. The presented results were
      obtained for samples retrieved from routine surgeries, namely knee or hip joints 
      replacements with implants, performed on individuals from Southern Poland. This
      allowed to collect representative sets of general public samples. The applied
      analytical radiochemical procedure for bone matrix is described in details. Due
      to low concentrations of (238)Pu the ratio of Pu isotopes which might be used for
      Pu source identification is obtained only as upper limits other then global
      fallout (for example Chernobyl) origin of Pu. Calculated concentrations of
      radioisotopes are comparable to the existing data from post-mortem studies on
      human bones retrieved from autopsy or exhumations. Human bones removed during
      knee or hip joint surgery provide a simple and ethical way for obtaining samples 
      for plutonium, americium and (90)Sr in-body contamination studies in general
      public.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Mietelski, Jerzy W
AU  - Mietelski JW
AD  - The Henryk Niewodniczanski Institute of Nuclear Physics, Polish Academy of
      Sciences, Radzikowskiego 152, 31-342 Cracow, Poland. jerzy.mietelski@ifj.edu.pl
FAU - Golec, Edward B
AU  - Golec EB
FAU - Tomankiewicz, Ewa
AU  - Tomankiewicz E
FAU - Golec, Joanna
AU  - Golec J
FAU - Nowak, Sebastian
AU  - Nowak S
FAU - Szczygiel, Elzbieta
AU  - Szczygiel E
FAU - Brudecki, Kamil
AU  - Brudecki K
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110321
PL  - England
TA  - J Environ Radioact
JT  - Journal of environmental radioactivity
JID - 8508119
RN  - 0 (Strontium Radioisotopes)
RN  - 53023GN24M (Plutonium)
RN  - VW92PHU2UY (Americium)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Americium/*analysis
MH  - Body Burden
MH  - Bone and Bones/*chemistry/surgery
MH  - Female
MH  - Hip Joint/*chemistry/surgery
MH  - Humans
MH  - Knee Joint/*chemistry/surgery
MH  - Male
MH  - Middle Aged
MH  - Plutonium/*analysis
MH  - Radiochemistry/*methods
MH  - Strontium Radioisotopes/*analysis
EDAT- 2011/03/23 06:00
MHDA- 2011/09/09 06:00
CRDT- 2011/03/23 06:00
PHST- 2010/03/18 00:00 [received]
PHST- 2011/02/04 00:00 [revised]
PHST- 2011/02/18 00:00 [accepted]
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2011/09/09 06:00 [medline]
AID - S0265-931X(11)00035-X [pii]
AID - 10.1016/j.jenvrad.2011.02.013 [doi]
PST - ppublish
SO  - J Environ Radioact. 2011 Jun;102(6):559-65. doi: 10.1016/j.jenvrad.2011.02.013.
      Epub 2011 Mar 21.


PMID- 21419897
OWN - NLM
STAT- MEDLINE
DCOM- 20110516
LR  - 20110322
IS  - 1097-685X (Electronic)
IS  - 0022-5223 (Linking)
VI  - 141
IP  - 4
DP  - 2011 Apr
TI  - The ethics of innovation: Columbus and others try something new.
PG  - 863-6
LID - 10.1016/j.jtcvs.2011.01.003 [doi]
FAU - McKneally, Martin F
AU  - McKneally MF
LA  - eng
PT  - Editorial
PL  - United States
TA  - J Thorac Cardiovasc Surg
JT  - The Journal of thoracic and cardiovascular surgery
JID - 0376343
SB  - IM
MH  - Clinical Competence
MH  - Conflict of Interest
MH  - Cost-Benefit Analysis
MH  - *Diffusion of Innovation
MH  - Evidence-Based Medicine/economics/*ethics
MH  - Health Care Costs
MH  - Humans
MH  - Informed Consent
MH  - Practice Guidelines as Topic
MH  - Risk Assessment
MH  - Therapies, Investigational/adverse effects/economics/*ethics
MH  - Thoracic Surgery/economics/*ethics
MH  - Thoracic Surgical Procedures/adverse effects/economics/*ethics
EDAT- 2011/03/23 06:00
MHDA- 2011/05/17 06:00
CRDT- 2011/03/23 06:00
PHST- 2010/12/14 00:00 [received]
PHST- 2010/12/14 00:00 [revised]
PHST- 2011/01/03 00:00 [accepted]
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2011/05/17 06:00 [medline]
AID - S0022-5223(11)00005-5 [pii]
AID - 10.1016/j.jtcvs.2011.01.003 [doi]
PST - ppublish
SO  - J Thorac Cardiovasc Surg. 2011 Apr;141(4):863-6. doi:
      10.1016/j.jtcvs.2011.01.003.


PMID- 21419540
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20220408
IS  - 1531-5053 (Electronic)
IS  - 0278-2391 (Linking)
VI  - 69
IP  - 7
DP  - 2011 Jul
TI  - Factors affecting incidence of dry socket: a prospective community-based study.
PG  - 1880-4
LID - 10.1016/j.joms.2010.11.006 [doi]
AB  - Dry socket, or alveolar osteitis, can occur because of the removal of teeth. No
      clear etiology has been acknowledged; however, numerous risk factors have been
      proposed and tested. We report on the results of a prospective, multicenter study
      of the incidence and factors affecting the occurrence of alveolar osteitis at the
      Royal Dental Hospital of Melbourne and Community Dental Clinics in Melbourne,
      Australia. Ethics approval was gained from the University of Melbourne and Dental
      Health Services Victoria. The data were analyzed in a descriptive fashion, and
      the factors affecting alveolar osteitis were assessed using logistic regression
      analysis. The incidence of alveolar osteitis was 2.3% of all teeth extracted,
      with 4.2% of all patients experiencing alveolar osteitis in a public dental
      setting. Multivariate analysis revealed operator experience, perioperative crown 
      and root fractures, periodontal disease, posterior teeth, and, interestingly, the
      use of mental health medications to be significant independent risk factors for
      the development of alveolar osteitis. No alveolar osteitis was reported in
      patients taking antibiotics, the oral contraceptive pill, bisphosphonates, or
      oral steroid drugs. Smoking and extraction technique (either operative or
      nonoperative) were also not found to significantly affect the development of
      alveolar osteitis.
CI  - Copyright (c) 2011 American Association of Oral and Maxillofacial Surgeons.
      Published by Elsevier Inc. All rights reserved.
FAU - Parthasarathi, Krishnan
AU  - Parthasarathi K
AD  - Oral and Maxillofacial Surgery, Prince of Wales Hospital, Sydney, New South
      Wales, Australia.
FAU - Smith, Andrew
AU  - Smith A
FAU - Chandu, Arun
AU  - Chandu A
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20110321
PL  - United States
TA  - J Oral Maxillofac Surg
JT  - Journal of oral and maxillofacial surgery : official journal of the American
      Association of Oral and Maxillofacial Surgeons
JID - 8206428
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Bone Density Conservation Agents)
RN  - 0 (Contraceptives, Oral)
RN  - 0 (Diphosphonates)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Psychotropic Drugs)
SB  - IM
CIN - J Oral Maxillofac Surg. 2011 Dec;69(12):2945; author reply 2946. PMID: 22117702
MH  - Anti-Bacterial Agents/therapeutic use
MH  - Bone Density Conservation Agents/therapeutic use
MH  - Contraceptives, Oral/therapeutic use
MH  - Dental Caries/epidemiology
MH  - Diphosphonates/therapeutic use
MH  - Dry Socket/*epidemiology
MH  - Female
MH  - Humans
MH  - Hypoglycemic Agents/therapeutic use
MH  - Incidence
MH  - Intraoperative Complications/epidemiology
MH  - Male
MH  - Mandibular Diseases/epidemiology
MH  - Oral Hygiene/statistics & numerical data
MH  - Periodontal Diseases/epidemiology
MH  - Postoperative Complications/epidemiology
MH  - Prospective Studies
MH  - Psychotropic Drugs/therapeutic use
MH  - Risk Factors
MH  - Smoking/epidemiology
MH  - Tooth Crown/injuries
MH  - Tooth Extraction/statistics & numerical data
MH  - Tooth Fractures/epidemiology
MH  - Tooth Root/injuries
MH  - Tooth Socket/pathology
MH  - Victoria/epidemiology
EDAT- 2011/03/23 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/03/23 06:00
PHST- 2010/04/05 00:00 [received]
PHST- 2010/09/21 00:00 [revised]
PHST- 2010/11/04 00:00 [accepted]
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - S0278-2391(10)01559-4 [pii]
AID - 10.1016/j.joms.2010.11.006 [doi]
PST - ppublish
SO  - J Oral Maxillofac Surg. 2011 Jul;69(7):1880-4. doi: 10.1016/j.joms.2010.11.006.
      Epub 2011 Mar 21.


PMID- 21419533
OWN - NLM
STAT- MEDLINE
DCOM- 20120425
LR  - 20151119
IS  - 1532-2793 (Electronic)
IS  - 0260-6917 (Linking)
VI  - 32
IP  - 1
DP  - 2012 Jan
TI  - A study of an ethics education topic for undergraduate nursing students.
PG  - 111-5
LID - 10.1016/j.nedt.2011.02.006 [doi]
AB  - The study aims to explore nursing students' perceptions of the relative value of 
      various aspects of the ethical component of the undergraduate topic, 'Ethics and 
      Law applied to Nursing' (topic NURS2104). To enable time for reflection on ethics
      in nursing, sampling occurred 1 year after successful completion of the
      above-mentioned topic and after successful completion of all but the final
      clinical experience components of the Bachelor of Nursing (BN) degree. A
      significant proportion of respondents perceived ethics education as relevant to
      professional practices. It is also noteworthy that the ethical decision-making
      strategies that had been incorporated into the topic (NURS2104) became
      transformed by the clinical experience of each particular student. While results 
      of this study are not conclusive, they nevertheless provide important information
      for future nursing students on the evolutionary development of ethics education.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Kalaitzidis, Evdokia
AU  - Kalaitzidis E
AD  - School of Nursing and Midwifery, Flinders University, Bedford Park, Adelaide
      South Australia, Australia. evdokia.kalaitzidis@flinders.edu.au
FAU - Schmitz, Karl
AU  - Schmitz K
LA  - eng
PT  - Journal Article
DEP - 20110317
PL  - Scotland
TA  - Nurse Educ Today
JT  - Nurse education today
JID - 8511379
MH  - Australia
MH  - *Curriculum
MH  - Decision Making/ethics
MH  - Education, Nursing, Baccalaureate/*ethics
MH  - Educational Measurement/methods
MH  - Educational Status
MH  - Ethics, Nursing/*education
MH  - Humans
MH  - Schools, Nursing/ethics
MH  - *Students, Nursing
MH  - Surveys and Questionnaires
MH  - Teaching/*methods
EDAT- 2011/03/23 06:00
MHDA- 2012/04/26 06:00
CRDT- 2011/03/23 06:00
PHST- 2010/12/07 00:00 [received]
PHST- 2011/02/08 00:00 [revised]
PHST- 2011/02/09 00:00 [accepted]
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2012/04/26 06:00 [medline]
AID - S0260-6917(11)00049-9 [pii]
AID - 10.1016/j.nedt.2011.02.006 [doi]
PST - ppublish
SO  - Nurse Educ Today. 2012 Jan;32(1):111-5. doi: 10.1016/j.nedt.2011.02.006. Epub
      2011 Mar 17.


PMID- 21419461
OWN - NLM
STAT- MEDLINE
DCOM- 20110920
LR  - 20111117
IS  - 1578-8989 (Electronic)
IS  - 0025-7753 (Linking)
VI  - 136
IP  - 15
DP  - 2011 May 28
TI  - [Medical ethics and pain].
PG  - 671-3
LID - 10.1016/j.medcli.2011.01.004 [doi]
FAU - Gamboa Antinolo, Fernando Miguel
AU  - Gamboa Antinolo FM
LA  - spa
PT  - Editorial
TT  - Etica medica y dolor.
DEP - 20110317
PL  - Spain
TA  - Med Clin (Barc)
JT  - Medicina clinica
JID - 0376377
RN  - 0 (Analgesics)
SB  - IM
MH  - Analgesia/adverse effects/*ethics/methods
MH  - Analgesics/adverse effects/therapeutic use
MH  - Attitude to Health
MH  - Dissent and Disputes
MH  - Humans
MH  - Pain/drug therapy/prevention & control/psychology
MH  - *Pain Management
MH  - Patient Preference
MH  - Personal Autonomy
MH  - Physician-Patient Relations
MH  - Professional Autonomy
MH  - Social Values
MH  - Stress, Psychological/etiology
EDAT- 2011/03/23 06:00
MHDA- 2011/09/21 06:00
CRDT- 2011/03/23 06:00
PHST- 2010/10/27 00:00 [received]
PHST- 2011/01/13 00:00 [revised]
PHST- 2011/01/25 00:00 [accepted]
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2011/09/21 06:00 [medline]
AID - S0025-7753(11)00098-4 [pii]
AID - 10.1016/j.medcli.2011.01.004 [doi]
PST - ppublish
SO  - Med Clin (Barc). 2011 May 28;136(15):671-3. doi: 10.1016/j.medcli.2011.01.004.
      Epub 2011 Mar 17.


PMID- 21419362
OWN - NLM
STAT- MEDLINE
DCOM- 20110718
LR  - 20220309
IS  - 1532-9283 (Electronic)
IS  - 1360-8592 (Linking)
VI  - 15
IP  - 2
DP  - 2011 Apr
TI  - Application of perineometer in the assessment of pelvic floor muscle strength and
      endurance: a reliability study.
PG  - 209-14
LID - 10.1016/j.jbmt.2009.07.007 [doi]
AB  - Despite different studies on the reliability of pelvic floor muscle assessment,
      there is still no general consensus on the most valid and reliable method. The
      purpose of this study was to investigate the intra-rater (within-day and
      between-days) reliability of perineometer in the assessment of pelvic floor
      muscle strength and endurance. Following ethical approval, 15 healthy women aged 
      from 22 to 50-years old, with no history of low back pain were recruited. The
      Peritron perineometer instrument was used to measure pelvic floor muscle strength
      and endurance. Two measurements were taken on the same day with an hour interval 
      to assess within-day reliability and the third measurement was taken five days
      later to determine between-days reliability. Intraclass Correlation Coefficients 
      (ICCs) and the level of agreement between measurements were used for data
      analysis. The high ICC values (0.95 for strength and 0.94 for endurance) and high
      level of agreement between measurements indicated high within-day reliability for
      pelvic floor muscle strength and endurance. The perineometer was also shown to be
      reliable for between-days measurements with high ICC (0.88 for strength and 0.83 
      for endurance) and high level of agreement between measurements. The results
      demonstrated that the perineometer appears to be a highly reliable method of
      measuring pelvic floor muscle strength and endurance when measurements are taken 
      in healthy subject by the same investigator.
CI  - Copyright (c) 2009 Elsevier Ltd. All rights reserved.
FAU - Rahmani, Nahid
AU  - Rahmani N
AD  - Physiotherapy Department, The University of Social Welfare and Rehabilitation
      Sciences, Evin, Tehran, Iran.
FAU - Mohseni-Bandpei, Mohammad A
AU  - Mohseni-Bandpei MA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090807
PL  - United States
TA  - J Bodyw Mov Ther
JT  - Journal of bodywork and movement therapies
JID - 9700068
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Muscle Strength/*physiology
MH  - Observer Variation
MH  - Pelvic Floor/*physiology
MH  - Physical Therapy Modalities/*instrumentation
MH  - Prospective Studies
MH  - Reproducibility of Results
EDAT- 2011/03/23 06:00
MHDA- 2011/07/19 06:00
CRDT- 2011/03/23 06:00
PHST- 2009/01/18 00:00 [received]
PHST- 2009/07/08 00:00 [revised]
PHST- 2009/07/08 00:00 [accepted]
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2011/07/19 06:00 [medline]
AID - S1360-8592(09)00089-8 [pii]
AID - 10.1016/j.jbmt.2009.07.007 [doi]
PST - ppublish
SO  - J Bodyw Mov Ther. 2011 Apr;15(2):209-14. doi: 10.1016/j.jbmt.2009.07.007. Epub
      2009 Aug 7.


PMID- 21419257
OWN - NLM
STAT- MEDLINE
DCOM- 20110526
LR  - 20110322
IS  - 1558-3171 (Electronic)
IS  - 0039-6109 (Linking)
VI  - 91
IP  - 2
DP  - 2011 Apr
TI  - Palliative surgical oncology.
PG  - 343-53, viii
LID - 10.1016/j.suc.2010.12.004 [doi]
AB  - Palliative surgical oncology is a relatively new concept, but builds on a long
      tradition in surgery. As the field of palliative medicine grows and becomes its
      own specialty, surgeons have been receiving some specialized training in
      palliative care; devising specific palliative surgical procedures; and
      reevaluating the ethics of their interactions with patients, especially for the
      selection of palliative surgical procedures. This is leading to a new form of
      surgical practice in which the emphasis is on relief of present or anticipated
      symptoms, even if the interventions do not prolong a patient's life span.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Hanna, Nader N
AU  - Hanna NN
AD  - Division of Surgical Oncology, University of Maryland School of Medicine,
      Baltimore, MD 21201, USA. nhanna@smail.umaryland.edu
FAU - Bellavance, Emily
AU  - Bellavance E
FAU - Keay, Timothy
AU  - Keay T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Surg Clin North Am
JT  - The Surgical clinics of North America
JID - 0074243
SB  - IM
MH  - Advance Directives
MH  - Communication
MH  - Curriculum
MH  - Decision Making
MH  - General Surgery/*education
MH  - Humans
MH  - Internship and Residency
MH  - Medical Futility
MH  - *Medical Oncology/ethics
MH  - *Palliative Care/ethics/organization & administration
MH  - Quality of Life
MH  - Surgical Procedures, Operative/ethics
EDAT- 2011/03/23 06:00
MHDA- 2011/05/27 06:00
CRDT- 2011/03/23 06:00
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2011/05/27 06:00 [medline]
AID - S0039-6109(10)00190-8 [pii]
AID - 10.1016/j.suc.2010.12.004 [doi]
PST - ppublish
SO  - Surg Clin North Am. 2011 Apr;91(2):343-53, viii. doi: 10.1016/j.suc.2010.12.004.


PMID- 21419253
OWN - NLM
STAT- MEDLINE
DCOM- 20110526
LR  - 20110322
IS  - 1558-3171 (Electronic)
IS  - 0039-6109 (Linking)
VI  - 91
IP  - 2
DP  - 2011 Apr
TI  - Spiritual dimensions of surgical palliative care.
PG  - 305-15, vii
LID - 10.1016/j.suc.2010.12.007 [doi]
AB  - The spiritual dimensions of surgical palliative care encompass recognition of
      mortality (physician and patient); knowledge of moral and ethical dilemmas of
      medical decision making; respect for each individual and for all belief systems; 
      responsibility to remain physically and psychologically present for the patient
      and family; and knowledge of when chaplains, palliative care professionals, or
      social workers should be consulted. Certain aspects of surgical palliative care
      distinguish it from palliative care in other medical disciplines such as the 2
      definitions (palliative procedure and palliative care), treating a
      disproportionate share of patients who suffer unforeseen tragic events, and the
      surgical system.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Tarpley, Margaret J
AU  - Tarpley MJ
AD  - Department of Surgery, Vanderbilt University, Nashville, TN 37232-2730, USA.
      Margaret.tarpley@vanderbilt.edu
FAU - Tarpley, John L
AU  - Tarpley JL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Surg Clin North Am
JT  - The Surgical clinics of North America
JID - 0074243
SB  - IM
MH  - Chaplaincy Service, Hospital
MH  - Culture
MH  - Decision Making
MH  - Humans
MH  - *Palliative Care
MH  - Physician-Patient Relations
MH  - Professional-Family Relations
MH  - *Spirituality
MH  - Surgical Procedures, Operative
MH  - Terminal Care
EDAT- 2011/03/23 06:00
MHDA- 2011/05/27 06:00
CRDT- 2011/03/23 06:00
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2011/05/27 06:00 [medline]
AID - S0039-6109(10)00193-3 [pii]
AID - 10.1016/j.suc.2010.12.007 [doi]
PST - ppublish
SO  - Surg Clin North Am. 2011 Apr;91(2):305-15, vii. doi: 10.1016/j.suc.2010.12.007.


PMID- 21419005
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20110322
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 91
IP  - 5
DP  - 2011 Feb 1
TI  - [A prevalence survey of infertility in Beijing, China].
PG  - 313-6
AB  - OBJECTIVE: To investigate the prevalence of infertility and its risk factors in
      the fertile-age couples of Beijing, China. METHODS: A cross-sectional survey on
      the prevalence and risk factors was conducted from July 2007 to May 2008 in 7
      Beijing districts. The districts were subdivided into the administrative units of
      "communities". A total of 33 communities were sampled and households selected
      randomly within each community. Of 5862 couples (women aged 20 - 49 years) who
      were eligible for an interview, 5632 (96.07%) provided information in relation to
      all the questionnaire questions. The other couples did not participate because
      they were not at home for the interview, or became incapacitated, refused or
      others. The trained interviewers administered a detailed questionnaire to each
      study couple at their home, collecting the relevant information about
      contraception, sexual practices, marriage and a complete pregnancy history. The
      definition of infertility in the study was "a noncontracepting couple who want
      another child or a child if childless tried to conceive for at least 2 years"
      following the WHO recommendation([c2]). The study protocol was approved by the
      ethics committee of National Research Institute for Family Planning (NRIFP).
      RESULTS: A total of 97 couples were classified as infertile. And the total
      prevalence of infertility in 7 Beijing districts was 1.72%. The standardized
      prevalence of infertility was 2.1%. 57 (58.76%) couples were classified as of
      primary infertility and 40 (41.24%) of secondary infertility. So the prevalence
      of primary and secondary infertilities were 1.01% and 0.71% respectively. In
      women, the prevalence of infertility was the highest in the age group of 20 - 29 
      (3.13%) and the lowest in the age group of 40 - 49 (1.38%). The prevalence rate
      of infertility in the women whose marriage age were younger than 20 years or
      elder than 29 years of age was apparently higher than those of the 20 - 29 years 
      old. The risk factors of infertility were tuberculosis (TB), endometriosis (EM)
      and pelvic infection disease (PID). CONCLUSION: The prevalence rate of
      infertility declines with age in women. Both EM and PID are the risk factors for 
      infertility.
FAU - Yang, Yan-Qing
AU  - Yang YQ
AD  - National Research Institute for Family Planning, Beijing 100081, China.
FAU - Shen, He
AU  - Shen H
FAU - Chen, Jie
AU  - Chen J
FAU - Chen, Zhen-Wen
AU  - Chen ZW
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
SB  - IM
MH  - Adult
MH  - China/epidemiology
MH  - Cross-Sectional Studies
MH  - Endometriosis/complications
MH  - Female
MH  - Humans
MH  - Infertility/*epidemiology/etiology
MH  - Middle Aged
MH  - Pelvic Inflammatory Disease/complications
MH  - Prevalence
MH  - Risk Factors
MH  - Young Adult
EDAT- 2011/03/23 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/03/23 06:00
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2011 Feb 1;91(5):313-6.


PMID- 21418632
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211020
IS  - 1758-9193 (Electronic)
VI  - 3
IP  - 2
DP  - 2011 Mar 21
TI  - For debate: substituting placebo controls in long-term Alzheimer's prevention
      trials.
PG  - 9
LID - 10.1186/alzrt68 [doi]
AB  - INTRODUCTION: Novel compounds with potential to attenuate or stop the progression
      of Alzheimer's disease (AD) from its presymptomatic stage to dementia are being
      tested in man. The study design commonly used is the long-term randomized,
      placebo-controlled trial (RPCT), meaning that many patients will receive placebo 
      for 18 months or longer. It is ethically problematic to expose presymptomatic AD 
      patients, who by definition are at risk of developing dementia, to prolonged
      placebo treatment. As an alternative to long-term RPCTs we propose a novel
      clinical study design, termed the placebo group simulation approach (PGSA), using
      mathematical models to forecast outcomes of presymptomatic AD patients from their
      own baseline data. Forecasted outcomes are compared with outcomes observed on
      candidate drugs, thus replacing a concomitant placebo group. METHODS: First
      models were constructed using mild cognitive impairment (MCI) data from the
      Alzheimer's Disease Neuroimaging Initiative (ADNI) database. One outcome is the
      Alzheimer Disease Assessment Scale - cognitive subscale (ADAScog) score after 24 
      months, predicted in a linear regression model; the other is the trajectory over 
      36 months of a composite neuropsychological test score (Neuro-Psychological
      Battery (NP-Batt)), using a mixed model. Demographics and clinical, biological
      and neuropsychological baseline values were tested as potential predictors in
      both models. RESULTS: ADAScog scores after 24 months are predicted from gender,
      obesity, Functional Assessment Questionnaire (FAQ) and baseline scores of
      Mini-Mental State Examination, ADAScog and NP-Batt with an R2 of 0.63 and a
      residual standard deviation of 0.67, allowing reasonably precise estimates of
      sample means. The model of the NP-Batt trajectory has random intercepts and
      slopes and fixed effects for body mass index, time, apolipoprotein E4, age, FAQ, 
      baseline scores of ADAScog and NP-Batt, and four interaction terms. Estimates of 
      the residual standard deviation range from 0.3 to 0.5 on a standard normal scale.
      If novel drug candidates are expected to diminish the negative slope of scores
      with time, a change of 0.04 per year could be detected in samples of 400 with a
      power of about 80%. CONCLUSIONS: First PGSA models derived from ADNI MCI data
      allow prediction of cognitive endpoints and trajectories that correspond well
      with real observed values. Corroboration of these models with data from other
      observational studies is ongoing. It is suggested that the PGSA may complement
      RPCT designs in forthcoming long-term drug studies with presymptomatic AD
      individuals.
FAU - Spiegel, Rene
AU  - Spiegel R
AD  - University Hospital Department of Geriatrics, Memory Clinic, Schanzenstrasse 55, 
      CH 4031 Basel, Switzerland. rene.spiegel@unibas.ch.
FAU - Berres, Manfred
AU  - Berres M
FAU - Miserez, Andre R
AU  - Miserez AR
FAU - Monsch, Andreas U
AU  - Monsch AU
CN  - Alzheimer's Disease Neuroimaging Initiative
LA  - eng
GR  - U19 AG010483/AG/NIA NIH HHS/United States
PT  - Journal Article
DEP - 20110321
PL  - England
TA  - Alzheimers Res Ther
JT  - Alzheimer's research & therapy
JID - 101511643
PMC - PMC3226271
EDAT- 2011/03/23 06:00
MHDA- 2011/03/23 06:01
CRDT- 2011/03/23 06:00
PHST- 2010/08/30 00:00 [received]
PHST- 2011/01/02 00:00 [revised]
PHST- 2011/03/21 00:00 [accepted]
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2011/03/23 06:01 [medline]
AID - alzrt68 [pii]
AID - 10.1186/alzrt68 [doi]
PST - epublish
SO  - Alzheimers Res Ther. 2011 Mar 21;3(2):9. doi: 10.1186/alzrt68.


PMID- 21418562
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20220129
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 12
DP  - 2011 Mar 18
TI  - Ethical issues in human genomics research in developing countries.
PG  - 5
LID - 10.1186/1472-6939-12-5 [doi]
AB  - BACKGROUND: Genome-wide association studies (GWAS) provide a powerful means of
      identifying genetic variants that play a role in common diseases. Such studies
      present important ethical challenges. An increasing number of GWAS is taking
      place in lower income countries and there is a pressing need to identify the
      particular ethical challenges arising in such contexts. In this paper, we draw
      upon the experiences of the MalariaGEN Consortium to identify specific ethical
      issues raised by such research in Africa, Asia and Oceania. DISCUSSION: We
      explore ethical issues in three key areas: protecting the interests of research
      participants, regulation of international collaborative genomics research and
      protecting the interests of scientists in low income countries. With regard to
      participants, important challenges are raised about community consultation and
      consent. Genomics research raises ethical and governance issues about sample
      export and ownership, about the use of archived samples and about the complexity 
      of reviewing such large international projects. In the context of protecting the 
      interests of researchers in low income countries, we discuss aspects of data
      sharing and capacity building that need to be considered for sustainable and
      mutually beneficial collaborations. SUMMARY: Many ethical issues are raised when 
      genomics research is conducted on populations that are characterised by lower
      average income and literacy levels, such as the populations included in
      MalariaGEN. It is important that such issues are appropriately addressed in such 
      research. Our experience suggests that the ethical issues in genomics research
      can best be identified, analysed and addressed where ethics is embedded in the
      design and implementation of such research projects.
FAU - de Vries, Jantina
AU  - de Vries J
AD  - The Ethox Centre, Department of Public Health and Primary Care, University of
      Oxford, Old Road Campus, Headington, Oxford, OX3 7LF, UK.
      jantina.devries@ethox.ox.ac.uk
FAU - Bull, Susan J
AU  - Bull SJ
FAU - Doumbo, Ogobara
AU  - Doumbo O
FAU - Ibrahim, Muntaser
AU  - Ibrahim M
FAU - Mercereau-Puijalon, Odile
AU  - Mercereau-Puijalon O
FAU - Kwiatkowski, Dominic
AU  - Kwiatkowski D
FAU - Parker, Michael
AU  - Parker M
LA  - eng
GR  - G0600230/MRC_/Medical Research Council/United Kingdom
GR  - WT 083326/Z/07/Z/WT_/Wellcome Trust/United Kingdom
GR  - G0600718/MRC_/Medical Research Council/United Kingdom
GR  - 087285/Z/08/Z/WT_/Wellcome Trust/United Kingdom
GR  - 077383/Z/05/Z/WT_/Wellcome Trust/United Kingdom
GR  - G19/9/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110318
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Databases, Factual/*ethics
MH  - *Developing Countries
MH  - Ethics Committees, Research
MH  - Ethics, Research
MH  - Genome-Wide Association Study/*ethics
MH  - Genomics/*ethics
MH  - Humans
MH  - Income
MH  - Informed Consent/*ethics
MH  - International Cooperation
MH  - *Malaria/genetics
MH  - Nontherapeutic Human Experimentation/*ethics
MH  - Ownership
MH  - *Research Personnel
MH  - *Research Subjects
MH  - Social Justice
PMC - PMC3076260
EDAT- 2011/03/23 06:00
MHDA- 2011/06/03 06:00
CRDT- 2011/03/23 06:00
PHST- 2010/10/04 00:00 [received]
PHST- 2011/03/18 00:00 [accepted]
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
AID - 1472-6939-12-5 [pii]
AID - 10.1186/1472-6939-12-5 [doi]
PST - epublish
SO  - BMC Med Ethics. 2011 Mar 18;12:5. doi: 10.1186/1472-6939-12-5.


PMID- 21418288
OWN - NLM
STAT- MEDLINE
DCOM- 20111027
LR  - 20110718
IS  - 1365-2648 (Electronic)
IS  - 0309-2402 (Linking)
VI  - 67
IP  - 8
DP  - 2011 Aug
TI  - Nurses' perceptions of attempting cardiopulmonary resuscitation on oldest old
      patients.
PG  - 1739-48
LID - 10.1111/j.1365-2648.2011.05622.x [doi]
AB  - AIM: This paper is a report of a study to explore nurses' thoughts and attitudes 
      about cardiopulmonary resuscitation of oldest old patients. BACKGROUND: Although 
      it is recognized that nurses and doctors have different approaches to
      resuscitation, little is known about nurses' attitudes towards attempting
      resuscitation of the oldest old (85+ years). METHODS: Ten nurses working in three
      hospitals participated in in-depth interviews during 2009-2010. The data were
      analysed according to a constructivist-grounded theory tradition. RESULTS: The
      appropriate availability of 'do not attempt resuscitation' orders was important
      to the participants. Participants experienced stress in end-of-life care
      situations when resuscitation status was not decided for patients they considered
      should have a 'do not attempt resuscitation' order. Participants acknowledged the
      difficulties in end-of-life decision-making, but stated that 'do not attempt
      resuscitation' orders are underused and sometimes delayed. Participants were
      sceptical about attempting resuscitation. Nevertheless, respect for patient
      autonomy was strong, and participants were adamant about the necessity of
      following the legal requirements governing resuscitation. Five of the
      participants had been asked by physicians to use 'slow codes', cardiopulmonary
      resuscitation efforts that intentionally are conducted too slowly for
      resuscitation to occur, and agreed this was unethical. Some participants
      described the information on cardiopulmonary resuscitation and 'do not attempt
      resuscitation' given by physicians to patients as inadequate. CONCLUSIONS:
      End-of-life decisions impact on nurses' comfort in their working situation as
      they face ethical dilemmas and anxiety about performing cardiopulmonary
      resuscitation. Greater collaboration between all stakeholders might reduce these.
      Nurses may need additional education or updates about laws about end-of-life
      treatment, as participants were unaware of current legislation concerning
      end-of-life decision-making.
CI  - (c) 2011 The Authors. Journal of Advanced Nursing (c) 2011 Blackwell Publishing
      Ltd.
FAU - Saevareid, Trygve Johannes
AU  - Saevareid TJ
AD  - Diakonhjemmet Hospital, Medical Department, Oslo, Norway. tjsaevareid@yahoo.com
FAU - Balandin, Susan
AU  - Balandin S
LA  - eng
PT  - Journal Article
DEP - 20110321
PL  - England
TA  - J Adv Nurs
JT  - Journal of advanced nursing
JID - 7609811
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged, 80 and over
MH  - *Attitude of Health Personnel
MH  - Cardiopulmonary Resuscitation/ethics/*nursing/psychology
MH  - Decision Making, Organizational
MH  - Ethics, Nursing
MH  - Female
MH  - Heart Arrest/therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Norway
MH  - Nurse's Role
MH  - Nurse-Patient Relations
MH  - Nurses/*psychology
MH  - Patient Preference
MH  - Personal Autonomy
MH  - Physicians
MH  - Qualitative Research
MH  - Resuscitation Orders/ethics/legislation & jurisprudence/psychology
MH  - Right to Die
MH  - Stress, Psychological/epidemiology
MH  - Treatment Outcome
EDAT- 2011/03/23 06:00
MHDA- 2011/10/28 06:00
CRDT- 2011/03/23 06:00
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2011/10/28 06:00 [medline]
AID - 10.1111/j.1365-2648.2011.05622.x [doi]
PST - ppublish
SO  - J Adv Nurs. 2011 Aug;67(8):1739-48. doi: 10.1111/j.1365-2648.2011.05622.x. Epub
      2011 Mar 21.


PMID- 21418227
OWN - NLM
STAT- MEDLINE
DCOM- 20110715
LR  - 20110322
IS  - 1440-1630 (Electronic)
IS  - 0045-0766 (Linking)
VI  - 58
IP  - 2
DP  - 2011 Apr
TI  - What needs to be done? Occupational therapy responsibilities and challenges
      regarding human rights.
PG  - 60-6
LID - 10.1111/j.1440-1630.2011.00922.x [doi]
AB  - BACKGROUND: Addressing human rights issues brings forth ethical and political
      responsibilities for occupational therapists and requires new epistemological and
      educational approaches. The way occupational therapists have faced these
      challenges has depended upon historical, cultural and social contexts. AIM AND
      METHOD: By means of literature review and historical analysis, this paper
      reflects on how occupational therapists have dealt with human matters issues and 
      on the contemporary changes within the profession. RESULTS AND DISCUSSION: The
      paper portrays how Latin American occupational therapists have engaged in social 
      transformation by choosing not to transform ethical and political problems into
      technical matters. Taking into account experiences and views from South Africa,
      Brazil and Chile, the paper outlines the importance of developing political
      literacy and interdisciplinary professional/postprofessional education to prepare
      the new generation of occupational therapists to engage in social transformation.
      Addressing issues of invisibility and lack of access to human rights, the paper
      reflects on the need of developing conceptual tools and strategies for change,
      and discusses the transformations being produced in contemporary occupational
      therapy. CONCLUSION: Occupational therapists and scientists need to be attentive 
      to human rights issues. They also need to answer the call for interconnectedness 
      in the present-day complex societies, and engage in networking and a
      cross-bordering dialogue. Nevertheless, although necessary and welcome,
      international cooperation requires a permanent exercise of cultural sensitivity, 
      political awareness and self-awareness.
CI  - (c) 2011 The Author. Australian Occupational Therapy Journal (c) 2011 Australian 
      Association of Occupational Therapists.
FAU - Galheigo, Sandra Maria
AU  - Galheigo SM
AD  - Department of Physiotherapy, Communication Science & Disorders, and Occupational 
      Therapy, Faculty of Medicine, University of Sao Paulo, Rua Cipotanea 51, Sao
      Paulo, Brazil. sandramg@usp.br
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Australia
TA  - Aust Occup Ther J
JT  - Australian occupational therapy journal
JID - 15420200R
SB  - IM
MH  - Cultural Competency
MH  - *Human Rights
MH  - Humans
MH  - International Cooperation
MH  - Latin America
MH  - Occupational Therapy/*ethics/standards
MH  - Patient Advocacy/*ethics/standards
MH  - Politics
MH  - *Social Change
MH  - Social Support
EDAT- 2011/03/23 06:00
MHDA- 2011/07/16 06:00
CRDT- 2011/03/23 06:00
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
AID - 10.1111/j.1440-1630.2011.00922.x [doi]
PST - ppublish
SO  - Aust Occup Ther J. 2011 Apr;58(2):60-6. doi: 10.1111/j.1440-1630.2011.00922.x.


PMID- 21418153
OWN - NLM
STAT- MEDLINE
DCOM- 20111209
LR  - 20181201
IS  - 1399-6576 (Electronic)
IS  - 0001-5172 (Linking)
VI  - 55
IP  - 5
DP  - 2011 May
TI  - Sniffing position combined with mouth opening improves facemask ventilation in
      children with adenotonsillar hypertrophy.
PG  - 530-4
LID - 10.1111/j.1399-6576.2011.02417.x [doi]
AB  - BACKGROUND: This study evaluates the influence of sniffing position combined with
      mouth opening on the effectiveness of facemask ventilation in paralyzed pediatric
      patients undergoing adenotonsillectomy during sevoflurane-N(2)O anesthesia.
      METHODS: After Institutional Ethics Committee approval, 40 children 5-11 years of
      age who were scheduled for an elective adenotonsillectomy operation were enrolled
      in this prospective randomized study. After routine monitoring and
      pre-oxygenation, anesthesia was induced with sevoflurane 8% in a mixture of 50%
      N(2)O-O(2). Three minutes after the administration of vecuronium, the sequence of
      the positions was randomized. Three positions were applied during facemask
      ventilation: Position CN (closed mouth - neutral head and neck position),
      position CS (closed mouth-sniffing position) and position OS (opened
      mouth-sniffing position). Volume-controlled ventilation was started. Peak
      inspiratory pressure (PIP), tidal volume (V(T)), expired tidal volume (V(Texp))
      and end-tidal CO(2) pressure were recorded. The percent of leakage was
      calculated. The primary endpoint of this study was the expired tidal volume
      (V(Texp)). RESULTS: There was a statistically significant difference among the
      three positions for V(Texp) and PIP values. The OS resulted in higher V(Texp)
      values when compared with CN (P=0.022). The OS was significantly better than the 
      other two positions, resulting in lower PIP values (P<0.001 and P=0.004, for CN
      and CS, respectively). The OS also resulted in less leakage during facemask
      ventilation when compared with CN and CS. CONCLUSIONS: Sniffing position combined
      with mouth opening improves V(Texp) and PIP values during facemask ventilation
      during sevoflurane-N(2)O anesthesia in paralyzed pediatric patients with
      adenotonsillar hypertrophy.
FAU - Cuvas, O
AU  - Cuvas O
AD  - Department of Anaesthesia and Intensive Care Medicine, Ankara Training and
      Research Hospital, Turkey. ozguncuvas@yahoo.com
FAU - Dikmen, B
AU  - Dikmen B
FAU - Yucel, F
AU  - Yucel F
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110321
PL  - England
TA  - Acta Anaesthesiol Scand
JT  - Acta anaesthesiologica Scandinavica
JID - 0370270
RN  - 0 (Anesthetics, Inhalation)
RN  - 0 (Methyl Ethers)
RN  - 142M471B3J (Carbon Dioxide)
RN  - 38LVP0K73A (Sevoflurane)
SB  - IM
MH  - *Adenoidectomy
MH  - Adenoids/*pathology
MH  - Anesthesia, Inhalation
MH  - Anesthetics, Inhalation/administration & dosage
MH  - Carbon Dioxide/blood
MH  - Child
MH  - Child, Preschool
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Hypertrophy
MH  - Male
MH  - Masks
MH  - Methyl Ethers/administration & dosage
MH  - *Mouth
MH  - Palatine Tonsil/*pathology
MH  - Peak Expiratory Flow Rate
MH  - *Posture
MH  - Preanesthetic Medication
MH  - Prospective Studies
MH  - Respiration, Artificial/*methods
MH  - Sevoflurane
MH  - Tidal Volume
MH  - *Tonsillectomy
EDAT- 2011/03/23 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/03/23 06:00
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 10.1111/j.1399-6576.2011.02417.x [doi]
PST - ppublish
SO  - Acta Anaesthesiol Scand. 2011 May;55(5):530-4. doi:
      10.1111/j.1399-6576.2011.02417.x. Epub 2011 Mar 21.


PMID- 21417842
OWN - NLM
STAT- MEDLINE
DCOM- 20110804
LR  - 20121115
IS  - 1365-2931 (Electronic)
IS  - 1364-5706 (Linking)
VI  - 20
IP  - 2
DP  - 2011 Apr
TI  - Open balloon aortic valvuloplasty in aortic stenosis: implications for
      transcatheter aortic valve implantations.
PG  - 95-100
LID - 10.3109/13645706.2011.553959 [doi]
AB  - Balloon aortic valvuloplasty (BAV) plays a crucial role in transcatheter aortic
      valve implantation (TAVI). However, data on morphology during BAV are lacking.
      During surgical aortic valve replacement, open BAV was performed as a
      non-therapeutic in-vivo model prior to aortic valve excision. Twenty-six patients
      with severe aortic stenosis were included in the study after ethics committee
      approval. A valvuloplasty balloon was advanced from the open aorta, across the
      stenotic aortic valve and was rapidly inflated and deflated. All patients except 
      for one had tricuspid aortic valves with severe visible calcification on the
      aortic side of leaflets. All valves were successfully dilated. Only in the
      presence of severe central calcific noduli, fractures occurred in the middle
      portion of the leaflets in three and in the commissural part in four patients. No
      embolization of valvular debris occurred, however, ten coronary leaflets
      partially reached coronary orifices, resulting in three near-obstructions. The
      present study visualized for the first time the behaviour of bulky leaflet
      calcifications during valvuloplasty. Fractures in the middle portion of the free 
      edge may occur whenever a huge calcification completely affects the whole leaflet
      area. No signs of embolization were observed, possibly explaining low stroke
      rates during TAVI procedures.
FAU - Wendt, Daniel
AU  - Wendt D
AD  - Department of Thoracic and Cardiovascular Surgery, West-German Heart Center
      Essen, University Hospital Essen, Essen, Germany. daniel.wendt@uk-essen.de
FAU - Tossios, Paschalis
AU  - Tossios P
FAU - Pasa, Susanne
AU  - Pasa S
FAU - Thielmann, Matthias
AU  - Thielmann M
FAU - Pizanis, Nikolaus
AU  - Pizanis N
FAU - Tsagakis, Konstantinos
AU  - Tsagakis K
FAU - Jakob, Heinz
AU  - Jakob H
LA  - eng
PT  - Journal Article
PL  - England
TA  - Minim Invasive Ther Allied Technol
JT  - Minimally invasive therapy & allied technologies : MITAT : official journal of
      the Society for Minimally Invasive Therapy
JID - 9612996
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aortic Valve/*pathology
MH  - Aortic Valve Stenosis/*therapy
MH  - Catheterization/instrumentation/*methods
MH  - Female
MH  - Heart Valve Prosthesis Implantation/instrumentation/*methods
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Sternotomy/instrumentation/methods
EDAT- 2011/03/23 06:00
MHDA- 2011/08/05 06:00
CRDT- 2011/03/23 06:00
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2011/08/05 06:00 [medline]
AID - 10.3109/13645706.2011.553959 [doi]
PST - ppublish
SO  - Minim Invasive Ther Allied Technol. 2011 Apr;20(2):95-100. doi:
      10.3109/13645706.2011.553959.


PMID- 21416899
OWN - NLM
STAT- MEDLINE
DCOM- 20110401
LR  - 20110321
IS  - 1268-6034 (Print)
IS  - 1268-6034 (Linking)
IP  - 87
DP  - 2011 Jan-Feb
TI  - [Setting up of a community/hospital network providing care for patients and their
      families].
PG  - 18-21
AB  - With the ageing of the population, dementia has become a public healthcare
      priority. A network designed to help the families of patients suffering from
      dementia on a medical as well as a social and psychological level has been set
      up. This structure has been developed in close coordination with community
      practitioners and physicians and in line with the latest recommendations in
      particular with regard to ethics. Its first three years of existence confirm the 
      importance of this type of approach which complements the care provided by
      hospitals.
FAU - Koskas, Pierre
AU  - Koskas P
AD  - Hopital Bretonneau. pierre.koskas@brt.aphp.fr
FAU - Misme, Aurelie
AU  - Misme A
FAU - Lepresle, Claude
AU  - Lepresle C
FAU - Drunat, Olivier
AU  - Drunat O
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Mise en place d'une structure ville/hopital de prise en charge des patients et de
      leurs familles.
PL  - France
TA  - Soins Gerontol
JT  - Soins. Gerontologie
JID - 9616322
MH  - Aged
MH  - Community Networks/ethics/*organization & administration
MH  - *Community-Institutional Relations
MH  - Dementia/epidemiology/*prevention & control
MH  - Health Services for the Aged/ethics/*organization & administration
MH  - Hospitals, Urban/ethics/*organization & administration
MH  - Humans
MH  - National Health Programs/ethics/organization & administration
MH  - Paris
MH  - Patient Care Team/ethics/*organization & administration
MH  - Program Development
EDAT- 2011/03/23 06:00
MHDA- 2011/04/02 06:00
CRDT- 2011/03/23 06:00
PHST- 2011/03/23 06:00 [entrez]
PHST- 2011/03/23 06:00 [pubmed]
PHST- 2011/04/02 06:00 [medline]
PST - ppublish
SO  - Soins Gerontol. 2011 Jan-Feb;(87):18-21.


PMID- 21402811
OWN - NLM
STAT- MEDLINE
DCOM- 20110324
LR  - 20220321
IS  - 1938-744X (Electronic)
IS  - 1935-7893 (Linking)
VI  - 5 Suppl 1
DP  - 2011 Mar
TI  - Resource allocation after a nuclear detonation incident: unaltered standards of
      ethical decision making.
PG  - S46-53
LID - 10.1001/dmp.2011.14 [doi]
AB  - This article provides practical ethical guidance for clinicians making decisions 
      after a nuclear detonation, in advance of the full establishment of a coordinated
      response. We argue that the utilitarian maxim of the greatest good for the
      greatest number, interpreted only as "the most lives saved," needs refinement. We
      take the philosophical position that utilitarian efficiency should be tempered by
      the principle of fairness in making decisions about providing lifesaving
      interventions and palliation. The most practical way to achieve these goals is to
      mirror the ethical precepts of routine clinical practice, in which 3 factors
      govern resource allocation: order of presentation, patient's medical need, and
      effectiveness of an intervention. Although these basic ethical standards do not
      change, priority is given in a crisis to those at highest need in whom
      interventions are expected to be effective. If available resources will not be
      effective in meeting the need, then it is unfair to expend them and they should
      be allocated to another patient with high need and greater expectation for
      survival if treated. As shortage becomes critical, thresholds for intervention
      become more stringent. Although the focus of providers will be on the victims of 
      the event, the needs of patients already receiving care before the detonation
      also must be considered. Those not allocated intervention must still be provided 
      as much appropriate comfort, assistance, relief of symptoms, and explanations as 
      possible, given the available resources. Reassessment of patients' clinical
      status and priority for intervention also should be conducted with regularity.
FAU - Caro, J Jaime
AU  - Caro JJ
AD  - Department of Epidemiology, Biostatistics and Occupational Health, McGill
      University. jaime.caro@mcgill.ca
FAU - DeRenzo, Evan G
AU  - DeRenzo EG
FAU - Coleman, C Norman
AU  - Coleman CN
FAU - Weinstock, David M
AU  - Weinstock DM
FAU - Knebel, Ann R
AU  - Knebel AR
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Disaster Med Public Health Prep
JT  - Disaster medicine and public health preparedness
JID - 101297401
SB  - IM
MH  - Decision Making/*ethics
MH  - Health Services Needs and Demand
MH  - Humans
MH  - *Nuclear Weapons
MH  - *Radioactive Hazard Release
MH  - Resource Allocation/*ethics
MH  - Severity of Illness Index
MH  - *Standard of Care
MH  - Terrorism
MH  - Treatment Outcome
MH  - *Triage
EDAT- 2011/03/22 06:00
MHDA- 2011/03/25 06:00
CRDT- 2011/03/16 06:00
PHST- 2011/03/16 06:00 [entrez]
PHST- 2011/03/22 06:00 [pubmed]
PHST- 2011/03/25 06:00 [medline]
AID - 5/Supplement_1/S46 [pii]
AID - 10.1001/dmp.2011.14 [doi]
PST - ppublish
SO  - Disaster Med Public Health Prep. 2011 Mar;5 Suppl 1:S46-53. doi:
      10.1001/dmp.2011.14.


PMID- 21402809
OWN - NLM
STAT- MEDLINE
DCOM- 20110324
LR  - 20220408
IS  - 1938-744X (Electronic)
IS  - 1935-7893 (Linking)
VI  - 5 Suppl 1
DP  - 2011 Mar
TI  - Allocation of scarce resources after a nuclear detonation: setting the context.
PG  - S20-31
LID - 10.1001/dmp.2011.25 [doi]
AB  - The purpose of this article is to set the context for this special issue of
      Disaster Medicine and Public Health Preparedness on the allocation of scarce
      resources in an improvised nuclear device incident. A nuclear detonation occurs
      when a sufficient amount of fissile material is brought suddenly together to
      reach critical mass and cause an explosion. Although the chance of a nuclear
      detonation is thought to be small, the consequences are potentially catastrophic,
      so planning for an effective medical response is necessary, albeit complex. A
      substantial nuclear detonation will result in physical effects and a great number
      of casualties that will require an organized medical response to save lives. With
      this type of incident, the demand for resources to treat casualties will far
      exceed what is available. To meet the goal of providing medical care (including
      symptomatic/palliative care) with fairness as the underlying ethical principle,
      planning for allocation of scarce resources among all involved sectors needs to
      be integrated and practiced. With thoughtful and realistic planning, the medical 
      response in the chaotic environment may be made more effective and efficient for 
      both victims and medical responders.
FAU - Knebel, Ann R
AU  - Knebel AR
AD  - Office of the Assistant Secretary for Preparedness and Response, Department of
      Health and Human Services, USA. ann.knebel@hhs.gov
FAU - Coleman, C Norman
AU  - Coleman CN
FAU - Cliffer, Kenneth D
AU  - Cliffer KD
FAU - Murrain-Hill, Paula
AU  - Murrain-Hill P
FAU - McNally, Richard
AU  - McNally R
FAU - Oancea, Victor
AU  - Oancea V
FAU - Jacobs, Jimmie
AU  - Jacobs J
FAU - Buddemeier, Brooke
AU  - Buddemeier B
FAU - Hick, John L
AU  - Hick JL
FAU - Weinstock, David M
AU  - Weinstock DM
FAU - Hrdina, Chad M
AU  - Hrdina CM
FAU - Taylor, Tammy
AU  - Taylor T
FAU - Matzo, Marianne
AU  - Matzo M
FAU - Bader, Judith L
AU  - Bader JL
FAU - Livinski, Alicia A
AU  - Livinski AA
FAU - Parker, Gerald
AU  - Parker G
FAU - Yeskey, Kevin
AU  - Yeskey K
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Disaster Med Public Health Prep
JT  - Disaster medicine and public health preparedness
JID - 101297401
RN  - 0 (Radioactive Fallout)
SB  - IM
MH  - *Disaster Planning
MH  - Emergency Medical Services/organization & administration
MH  - Explosions/classification
MH  - Humans
MH  - Mass Casualty Incidents/statistics & numerical data
MH  - *Nuclear Weapons
MH  - Palliative Care
MH  - Radiation Injuries/therapy
MH  - *Radioactive Fallout
MH  - *Radioactive Hazard Release/classification
MH  - Resource Allocation/*methods
MH  - Terrorism
MH  - Triage
EDAT- 2011/03/22 06:00
MHDA- 2011/03/25 06:00
CRDT- 2011/03/16 06:00
PHST- 2011/03/16 06:00 [entrez]
PHST- 2011/03/22 06:00 [pubmed]
PHST- 2011/03/25 06:00 [medline]
AID - 5/Supplement_1/S20 [pii]
AID - 10.1001/dmp.2011.25 [doi]
PST - ppublish
SO  - Disaster Med Public Health Prep. 2011 Mar;5 Suppl 1:S20-31. doi:
      10.1001/dmp.2011.25.


PMID- 21416581
OWN - NLM
STAT- MEDLINE
DCOM- 20120106
LR  - 20220408
IS  - 1545-5017 (Electronic)
IS  - 1545-5009 (Linking)
VI  - 57
IP  - 6
DP  - 2011 Dec 1
TI  - Knowledge and health beliefs of Jamaican adolescents with sickle cell disease.
PG  - 1044-8
LID - 10.1002/pbc.23091 [doi]
AB  - BACKGROUND: The adolescent stage of life is generally perceived to be a
      challenging period, which may be magnified when a chronic illness such as sickle 
      cell disease (SCD) is present. In this study, we sought to determine the
      knowledge and health beliefs of Jamaican adolescents with SCD as these factors
      may impact their self-management skills. PROCEDURE: An interviewer-administered
      questionnaire was completed by 117 patients (93 SS:24 SC; 48 males:69 females)
      between the ages of 15 and 19 years at their routine health maintenance visit to 
      the Sickle Cell Unit, UWI. A maximum total score of 17 could be attained for
      knowledge. The health belief questions were assessed using a 5-point Likert scale
      and correlations between knowledge and health beliefs were done. Multiple
      regression models were created to study the predictors of knowledge and health
      belief scores. The study was granted ethical approval by UWI/UHWI Ethics
      Committee. RESULTS: The mean knowledge score was 64% (range 88-29%). No
      differences were found in the mean knowledge scores between genotypes and
      educational attainment but females appeared to score higher than males (P-value
      <0.05). Most adolescents perceived SCD to be a severe illness and thought it is
      important for people to know their SCD status. However, almost 30% thought their 
      partners would be hard to convince for testing. Higher knowledge scores predicted
      positive health beliefs in the adolescent. CONCLUSIONS: Whereas most adolescents 
      were knowledgeable about how the disease was inherited and tested for, further
      education especially about disease and pregnancy complications is needed.
CI  - Copyright (c) 2011 Wiley-Liss, Inc.
FAU - Bhatt, Komal
AU  - Bhatt K
AD  - Sickle Cell Unit, Tropical Medicine Research Institute, University of the West
      Indies, Mona Campus, Kingston, Jamaica.
FAU - Reid, Marvin E
AU  - Reid ME
FAU - Lewis, Norma A
AU  - Lewis NA
FAU - Asnani, Monika R
AU  - Asnani MR
LA  - eng
PT  - Journal Article
DEP - 20110317
PL  - United States
TA  - Pediatr Blood Cancer
JT  - Pediatric blood & cancer
JID - 101186624
SB  - IM
MH  - Adolescent
MH  - *Anemia, Sickle Cell/diagnosis/genetics/psychology
MH  - Female
MH  - Genotype
MH  - *Health Behavior
MH  - Health Education
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Jamaica
MH  - Linear Models
MH  - Male
MH  - Predictive Value of Tests
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2011/03/19 06:00
MHDA- 2012/01/10 06:00
CRDT- 2011/03/19 06:00
PHST- 2010/09/23 00:00 [received]
PHST- 2011/01/25 00:00 [accepted]
PHST- 2011/03/19 06:00 [entrez]
PHST- 2011/03/19 06:00 [pubmed]
PHST- 2012/01/10 06:00 [medline]
AID - 10.1002/pbc.23091 [doi]
PST - ppublish
SO  - Pediatr Blood Cancer. 2011 Dec 1;57(6):1044-8. doi: 10.1002/pbc.23091. Epub 2011 
      Mar 17.


PMID- 21416397
OWN - NLM
STAT- MEDLINE
DCOM- 20110804
LR  - 20211203
IS  - 1433-0385 (Electronic)
IS  - 0009-4722 (Linking)
VI  - 82
IP  - 3
DP  - 2011 Mar
TI  - [Challenges in the organization of investigator initiated trials: in
      transplantation medicine].
PG  - 249-54
LID - 10.1007/s00104-010-1997-0 [doi]
AB  - INTRODUCTION: Transplantation medicine offers multiple translational questions
      which should preferably be transferred to clinical evidence. The current gold
      standard for testing such questions and hypotheses is by prospective randomized
      controlled trials (RCT). The trials should be performed independently from the
      medical industry to avoid conflicts of interests and to guarantee a strict
      scientific approach. A good model is an investigator initiated trial (IIT) in
      which academic institutions function as the sponsor and in which normally a
      scientific idea stands before marketing interests of a certain medical product.
      METHODS: We present a model for an IIT which is sponsored and coordinated by
      Regensburg University Hospital at 45 sites in 13 nations (SiLVER study),
      highlight special pitfalls of this study and offer alternatives to this approach.
      RESULTS: Finances: financial support in clinical trials can be obtained from the 
      medical industry. Alternatively in Germany the Federal Ministry of Education and 
      Research (Bundesministerium fur Bildung und Forschung) offers annual grants. The 
      expansion of financial support through foundations is desirable. Infrastructure: 
      sponsorship within the pharmaceutics act (Arzneimittelgesetz) demands excellent
      infrastructural conditions and a professional team to accomplish clinical,
      logistic, regulatory, legal and ethical challenges in a RCT. If a large trial has
      sufficient financial support certain tasks can be outsourced and delegated to
      contract research organizations, coordinating centers for clinical trials or
      partners in the medical industry. CONCLUSIONS: Clinical scientific advances to
      improve evidence are an enormous challenge when performed as an IIT. However,
      academic sponsors can perform (international) IITs when certain rules are
      followed and should be defined as the gold standard when scientific findings have
      to be established clinically.
FAU - Schnitzbauer, A A
AU  - Schnitzbauer AA
AD  - Klinik und Poliklinik fur Chirurgie, Universitatsklinikum Regensburg,
      Franz-Josef-Strauss-Allee 11, Regensburg, Germany.
      andreas.schnitzbauer@klinik.uni-r.de
FAU - Lamby, P E
AU  - Lamby PE
FAU - Mutzbauer, I
AU  - Mutzbauer I
FAU - von Hassel, J
AU  - von Hassel J
FAU - Geissler, E K
AU  - Geissler EK
FAU - Schlitt, H J
AU  - Schlitt HJ
LA  - ger
PT  - Journal Article
PT  - Review
TT  - Herausforderungen in der Organisation "investigator initiated trials": Am
      Beispiel der Transplantationsmedizin.
PL  - Germany
TA  - Chirurg
JT  - Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
JID - 16140410R
SB  - IM
MH  - Conflict of Interest
MH  - Drug Industry/ethics
MH  - *Ethics, Research
MH  - Evidence-Based Medicine/ethics/organization & administration
MH  - Financing, Government/ethics/organization & administration
MH  - Germany
MH  - Hospitals, University/ethics/organization & administration
MH  - Humans
MH  - Marketing/ethics/organization & administration
MH  - Multicenter Studies as Topic/ethics/methods
MH  - Outsourced Services/ethics/organization & administration
MH  - Prospective Studies
MH  - Randomized Controlled Trials as Topic/*ethics/*methods
MH  - Research Personnel/*ethics/*organization & administration
MH  - Research Support as Topic/ethics/organization & administration
MH  - Translational Research, Biomedical/ethics/organization & administration
MH  - Transplantation/*ethics/*methods
EDAT- 2011/03/19 06:00
MHDA- 2011/08/05 06:00
CRDT- 2011/03/19 06:00
PHST- 2011/03/19 06:00 [entrez]
PHST- 2011/03/19 06:00 [pubmed]
PHST- 2011/08/05 06:00 [medline]
AID - 10.1007/s00104-010-1997-0 [doi]
PST - ppublish
SO  - Chirurg. 2011 Mar;82(3):249-54. doi: 10.1007/s00104-010-1997-0.


PMID- 21416240
OWN - NLM
STAT- MEDLINE
DCOM- 20120515
LR  - 20211020
IS  - 1437-7772 (Electronic)
IS  - 1341-9625 (Linking)
VI  - 16
IP  - 6
DP  - 2011 Dec
TI  - First case of vaginal radical trachelectomy in a pregnant Japanese woman.
PG  - 737-40
LID - 10.1007/s10147-011-0209-3 [doi]
AB  - A diagnosis of cervical cancer during pregnancy poses difficult management and
      ethical problems. Survival of the patient is the foremost concern, but fetal
      viability and well-being must also be addressed. Radical trachelectomy (RT) has
      recently begun to be performed as a possible treatment modality for early stage
      invasive uterine cervical cancer in pregnant patients who would like to continue 
      their pregnancy. A 32-year-old Japanese woman visited a local hospital for
      prenatal care, and was diagnosed with a FIGO I B1 adenocarcinoma of the uterine
      cervix. She had a strong desire to avoid pregnancy termination, so she was
      admitted to our hospital for fertility-preserving surgery. After extensive
      counseling, vaginal radical trachelectomy with abdominal pelvic lymphadenectomy
      was performed in the 16th gestational week. The excised uterine cervix and lymph 
      nodes were pathologically negative for cancer. To maintain her pregnancy, daily
      vaginal disinfection with povidone iodine, bed rest, and administration of
      ritodrine and an ulinastatin vaginal suppository were continued until the
      delivery. At 34 weeks' gestation, an emergency cesarean section was performed
      because of sudden premature rupture of the membranes. A baby girl was born
      weighing 2112 g, with Apgar score of 8/9. The mother remains without evidence of 
      recurrence at the time of this report. This is the first case of successful
      pregnancy and delivery in Japan after vaginal RT.
FAU - Iwami, Nanako
AU  - Iwami N
AD  - Department of Obstetrics and Gynecology, Sapporo Medical University, Minami 1-jo 
      Nishi 16-chome, Chuo-ku, Sapporo, Hokkaido 064-8453, Japan.
FAU - Ishioka, Shin-ichi
AU  - Ishioka S
FAU - Endo, Toshiaki
AU  - Endo T
FAU - Baba, Tsuyoshi
AU  - Baba T
FAU - Nagasawa, Kunihiko
AU  - Nagasawa K
FAU - Takahashi, Madoka
AU  - Takahashi M
FAU - Sugio, Asuka
AU  - Sugio A
FAU - Takada, Sakura
AU  - Takada S
FAU - Mariya, Tasuku
AU  - Mariya T
FAU - Mizunuma, Masahiro
AU  - Mizunuma M
FAU - Saito, Tsuyoshi
AU  - Saito T
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20110318
PL  - Japan
TA  - Int J Clin Oncol
JT  - International journal of clinical oncology
JID - 9616295
SB  - IM
MH  - Adenocarcinoma/diagnosis/pathology/*surgery
MH  - Adult
MH  - Cesarean Section
MH  - Female
MH  - Gynecologic Surgical Procedures
MH  - Humans
MH  - Hysterectomy
MH  - Infant, Newborn
MH  - Japan
MH  - Lymph Node Excision
MH  - Neoplasm Staging
MH  - Pregnancy
MH  - Pregnancy Complications, Neoplastic/pathology/*surgery
MH  - Uterine Cervical Neoplasms/diagnosis/pathology/*surgery
EDAT- 2011/03/19 06:00
MHDA- 2012/05/16 06:00
CRDT- 2011/03/19 06:00
PHST- 2010/12/21 00:00 [received]
PHST- 2011/02/13 00:00 [accepted]
PHST- 2011/03/19 06:00 [entrez]
PHST- 2011/03/19 06:00 [pubmed]
PHST- 2012/05/16 06:00 [medline]
AID - 10.1007/s10147-011-0209-3 [doi]
PST - ppublish
SO  - Int J Clin Oncol. 2011 Dec;16(6):737-40. doi: 10.1007/s10147-011-0209-3. Epub
      2011 Mar 18.


PMID- 21416064
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220311
IS  - 1754-9973 (Print)
IS  - 1754-9973 (Linking)
VI  - 4
IP  - 1
DP  - 2011 Apr
TI  - Working with Concepts: The Role of Community in International Collaborative
      Biomedical Research.
PG  - 26-39
AB  - The importance of communities in strengthening the ethics of international
      collaborative research is increasingly highlighted, but there has been much
      debate about the meaning of the term 'community' and its specific normative
      contribution. We argue that 'community' is a contingent concept that plays an
      important normative role in research through the existence of morally significant
      interplay between notions of community and individuality. We draw on experience
      of community engagement in rural Kenya to illustrate two aspects of this
      interplay: (i) that taking individual informed consent seriously involves
      understanding and addressing the influence of communities in which individuals'
      lives are embedded; (ii) that individual participation can generate risks and
      benefits for communities as part of the wider implications of research. We
      further argue that the contingent nature of a community means that defining
      boundaries is generally a normative process itself, with ethical implications.
      Community engagement supports the enactment of normative roles; building mutual
      understanding and trust between researchers and community members have been
      important goals in Kilifi, requiring a broad range of approaches. Ethical
      dilemmas are continuously generated as part of these engagement activities,
      including the risks of perverse outcomes related to existing social relations in 
      communities and conditions of 'half knowing' intrinsic to processes of developing
      new understandings.
FAU - Marsh, V M
AU  - Marsh VM
AD  - The Kenya Medical Research Institute (KEMRI)- Wellcome Trust Research programme; 
      The Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of
      Medicine, Oxford University; The Ethox Centre, Department of Public Health and
      Primary Health Care, Oxford University.
FAU - Kamuya, D K
AU  - Kamuya DK
FAU - Parker, M J
AU  - Parker MJ
FAU - Molyneux, C S
AU  - Molyneux CS
LA  - eng
PT  - Journal Article
DEP - 20110302
PL  - England
TA  - Public Health Ethics
JT  - Public health ethics
JID - 101463048
PMC - PMC3058176
EDAT- 2011/03/19 06:00
MHDA- 2011/03/19 06:01
CRDT- 2011/03/19 06:00
PHST- 2011/03/19 06:00 [entrez]
PHST- 2011/03/19 06:00 [pubmed]
PHST- 2011/03/19 06:01 [medline]
AID - 10.1093/phe/phr007 [doi]
PST - ppublish
SO  - Public Health Ethics. 2011 Apr;4(1):26-39. doi: 10.1093/phe/phr007. Epub 2011 Mar
      2.


PMID- 21415829
OWN - NLM
STAT- MEDLINE
DCOM- 20110630
LR  - 20110318
IS  - 1531-7013 (Electronic)
IS  - 1087-2418 (Linking)
VI  - 16
IP  - 2
DP  - 2011 Apr
TI  - The elderly as recipients of living donor kidneys, how old is too old?
PG  - 250-5
LID - 10.1097/MOT.0b013e328344bfd6 [doi]
AB  - PURPOSE OF REVIEW: Transplantation of the elderly often invokes strong and
      sometimes passionate arguments both in support and in opposition. Age alone has
      not been an absolute contraindication to a life-sustaining organ transplant for
      several decades. A comprehensive evaluation of the risks associated with surgery 
      and suppression of the immune system in this often comorbid population becomes
      the focus. Risk for the recipient, however, must continually be evaluated and
      frequently updated in the context of that for the donor. RECENT FINDINGS:
      Following careful and critical evaluation, elderly patients appreciate the
      increase in life expectancy and improvements in quality of life as demonstrated
      in their younger counterparts. The outcome of recipients receiving kidneys from
      living donors has demonstrated superior graft and patient survival compared to
      deceased donors. Careful monitoring of medication levels for prevention of
      rejection while avoiding over immunosuppression and infection is critical to
      ensure such benefit. SUMMARY: Transplantation of the elderly via living donation 
      is not only justified but in the appropriately chosen patient, with informed
      consent of both donor and recipient, is ethically sound. The expectations of both
      parties must be clearly stated and donor safety must remain the top priority.
      Living donors must be fully cognizant of the potential risk both in patient and
      graft survival prior to making such a life-changing decision to donate.
FAU - Cooper, Matthew
AU  - Cooper M
AD  - University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
      mcooper@smail.umaryland.edu
FAU - Forland, Cynthia L
AU  - Forland CL
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Organ Transplant
JT  - Current opinion in organ transplantation
JID - 9717388
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - *Aging
MH  - Graft Rejection/etiology/prevention & control
MH  - Graft Survival
MH  - Health Services Accessibility
MH  - Healthcare Disparities
MH  - Humans
MH  - *Kidney Transplantation/adverse effects/mortality
MH  - *Living Donors
MH  - Middle Aged
MH  - *Patient Selection
MH  - Quality of Life
MH  - Risk Assessment
MH  - Risk Factors
MH  - Treatment Outcome
MH  - Waiting Lists
EDAT- 2011/03/19 06:00
MHDA- 2011/07/01 06:00
CRDT- 2011/03/19 06:00
PHST- 2011/03/19 06:00 [entrez]
PHST- 2011/03/19 06:00 [pubmed]
PHST- 2011/07/01 06:00 [medline]
AID - 10.1097/MOT.0b013e328344bfd6 [doi]
AID - 00075200-201104000-00020 [pii]
PST - ppublish
SO  - Curr Opin Organ Transplant. 2011 Apr;16(2):250-5. doi:
      10.1097/MOT.0b013e328344bfd6.


PMID- 21415822
OWN - NLM
STAT- MEDLINE
DCOM- 20110630
LR  - 20110318
IS  - 1531-7013 (Electronic)
IS  - 1087-2418 (Linking)
VI  - 16
IP  - 2
DP  - 2011 Apr
TI  - Intracerebral xenotransplantation: recent findings and perspectives for local
      immunosuppression.
PG  - 190-4
LID - 10.1097/MOT.0b013e32834494b5 [doi]
AB  - PURPOSE OF REVIEW: Cell therapy is a promising strategy for tissue repair in the 
      central nervous system. In this perspective, several cell types are being
      considered, including allogenic neuroblasts, embryonic stem cells and induced
      pluripotent stem cells. The use of allogenic neuroblasts as cell source is
      limited by logistics and ethical problems whereas transplantation of the last two
      cell types is hampered by their propensity to generate tumour. In this context,
      transplantation of xenogeneic neural cells appears as an attractive approach for 
      effective neuronal replacement in case of neurodegenerative disorders. RECENT
      FINDINGS: With the emergence of embryonic and induced pluripotent stem cells as
      potential cell source in regenerative medicine, little attention has been paid to
      the possibility of transplanting xenogenic neural cells in the central nervous
      system. However, recent progress to circumvent the host immune response in the
      brain has raised encouraging perspectives for intracerebral xenotransplantation
      as restorative strategy. SUMMARY: To date, most of the immunosuppressive
      strategies designed for long-term survival of intracerebral neural transplants
      were based on systemic immunosuppression that has detrimental side-effects. The
      immunological status of the brain and the presence of the blood-brain barrier
      raise the possibility of local immunosuppression. This article provides an
      overview of the strategies recently developed to protect intracerebral neural
      transplants with special focus on local immunosuppression.
FAU - Leveque, Xavier
AU  - Leveque X
AD  - INSERM, UMR643, CHU de Nantes, Institut de Transplantation-Urologie-Nephrologie, 
      ITUN, France.
FAU - Cozzi, Emanuele
AU  - Cozzi E
FAU - Naveilhan, Philippe
AU  - Naveilhan P
FAU - Neveu, Isabelle
AU  - Neveu I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Curr Opin Organ Transplant
JT  - Current opinion in organ transplantation
JID - 9717388
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Animals
MH  - Brain/immunology/*surgery
MH  - Cell Survival
MH  - Graft Survival
MH  - Humans
MH  - Immunosuppressive Agents/therapeutic use
MH  - Nerve Regeneration
MH  - Neurons/immunology/*transplantation
MH  - *Stem Cell Transplantation
MH  - *Transplantation Tolerance
MH  - *Transplantation, Heterologous
MH  - Treatment Outcome
EDAT- 2011/03/19 06:00
MHDA- 2011/07/01 06:00
CRDT- 2011/03/19 06:00
PHST- 2011/03/19 06:00 [entrez]
PHST- 2011/03/19 06:00 [pubmed]
PHST- 2011/07/01 06:00 [medline]
AID - 10.1097/MOT.0b013e32834494b5 [doi]
AID - 00075200-201104000-00010 [pii]
PST - ppublish
SO  - Curr Opin Organ Transplant. 2011 Apr;16(2):190-4. doi:
      10.1097/MOT.0b013e32834494b5.


PMID- 21415248
OWN - NLM
STAT- MEDLINE
DCOM- 20110902
LR  - 20220129
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 260
IP  - 1
DP  - 2011 Jul
TI  - Rapid flow assessment of congenital heart disease with
      high-spatiotemporal-resolution gated spiral phase-contrast MR imaging.
PG  - 79-87
LID - 10.1148/radiol.11101844 [doi]
AB  - PURPOSE: To validate a prospectively triggered spiral phase-contrast magnetic
      resonance (MR) sequence accelerated with sensitivity encoding (SENSE) in a
      population of children and adults with congenital heart disease. MATERIALS AND
      METHODS: The local research ethics committee approved this study, and written
      consent was obtained from all patients or guardians. Stroke volumes were
      quantified in 40 patients (mean age +/- standard deviation: 21.4 years +/- 13.8, 
      age range: 3.0-61.3 years; 22 male patients aged 3.0-38.0 years [mean age, 17.2
      years +/- 10.5], 18 female patients aged 4.7-61.3 years [mean age, 26.6 years +/-
      15.9]) with congenital heart disease in the aorta (n = 40), main pulmonary artery
      (n = 38), right pulmonary artery (n = 22), and left pulmonary artery (n = 24).
      Stroke volumes were obtained with (a) breath-hold spiral phase-contrast MR
      imaging with SENSE, (b) conventional breath-hold cartesian phase-contrast MR
      imaging, and (c) reference free-breathing phase-contrast MR imaging. Stroke
      volumes were compared by using repeated-measures analysis of variance,
      Bland-Altman analysis, and correlation coefficients. RESULTS: Imaging time with
      the breath-hold spiral phase-contrast MR sequence was significantly lower than
      that with the conventional breath-hold phase-contrast MR sequence (~5 seconds vs 
      ~16 seconds, respectively; P < .0001). There was excellent agreement in stroke
      volumes in all vessels between the reference free-breathing sequence (mean
      volume, 60.3 mL +/- 27.3) and the two breath-hold sequences-spiral SENSE
      phase-contrast MR imaging (mean volume, 59.5 mL +/- 27.1; P < .001) and
      conventional cartesian phase-contrast MR imaging (mean volume, 59.8 mL +/- 27.6; 
      P = .268). The limits of agreement were smaller with the spiral breath-hold
      sequence than with the conventional breath-hold sequence (-4.4 mL, 2.9 mL vs
      -10.3 mL, 9.3 mL, respectively); correlation was similar (r = 0.998 vs r = 0.984,
      respectively). CONCLUSION: Flow volumes can be accurately and reliably quantified
      by using a spiral SENSE phase-contrast MR sequence, with high spatiotemporal
      resolution obtained in a short breath hold.
FAU - Steeden, Jennifer A
AU  - Steeden JA
AD  - Centre for Medical Image Computing, UCL Department of Medical Physics &
      Bioengineering, London, England.
FAU - Atkinson, David
AU  - Atkinson D
FAU - Hansen, Michael S
AU  - Hansen MS
FAU - Taylor, Andrew M
AU  - Taylor AM
FAU - Muthurangu, Vivek
AU  - Muthurangu V
LA  - eng
GR  - FS/08/012/24454/BHF_/British Heart Foundation/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20110317
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Blood Flow Velocity
MH  - Cardiac-Gated Imaging Techniques/*methods
MH  - Child
MH  - Child, Preschool
MH  - *Coronary Circulation
MH  - Female
MH  - Heart Defects, Congenital/*pathology/*physiopathology
MH  - Humans
MH  - Image Interpretation, Computer-Assisted/*methods
MH  - Magnetic Resonance Angiography/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardial Perfusion Imaging/*methods
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Young Adult
PMC - PMC3121014
EDAT- 2011/03/19 06:00
MHDA- 2011/09/03 06:00
CRDT- 2011/03/19 06:00
PHST- 2011/03/19 06:00 [entrez]
PHST- 2011/03/19 06:00 [pubmed]
PHST- 2011/09/03 06:00 [medline]
AID - radiol.11101844 [pii]
AID - 10.1148/radiol.11101844 [doi]
PST - ppublish
SO  - Radiology. 2011 Jul;260(1):79-87. doi: 10.1148/radiol.11101844. Epub 2011 Mar 17.


PMID- 21415194
OWN - NLM
STAT- MEDLINE
DCOM- 20110816
LR  - 20110318
IS  - 1527-1323 (Electronic)
IS  - 0271-5333 (Linking)
VI  - 31
IP  - 2
DP  - 2011 Mar-Apr
TI  - EXIT procedure: technique and indications with prenatal imaging parameters for
      assessment of airway patency.
PG  - 511-26
LID - 10.1148/rg.312105108 [doi]
AB  - Successful management of fetal conditions in which airway obstruction is
      anticipated is now possible because of advances in prenatal imaging and the
      development of innovative techniques to secure the fetal airway before complete
      separation of the fetus from the maternal circulation. Fetal ultrasonography and 
      fetal magnetic resonance imaging are complementary imaging modalities in the
      assessment of fetuses with potential airway obstruction. The ex utero intrapartum
      therapy (EXIT) procedure is used to secure the fetal airway before complete
      delivery of the fetus. However, successful intrapartum treatment of fetuses who
      may need prolonged placental support depends on a multidisciplinary assessment in
      which the benefits of the EXIT procedure for the fetus are weighed against the
      risk of maternal complications that may occur during prolongation of the
      intrapartum period to secure the fetal airway. This multidisciplinary approach
      requires an understanding of the types of lesions in which intrapartum fetal
      airway access would be beneficial, a knowledge of the prenatal images that would 
      best delineate the anatomic defect and thus help guide the best approach to
      securing the airway, and consensus and coordination among medical ethicists,
      radiologists, obstetric anesthesiologists and obstetricians, pediatric surgeons
      and anesthesiologists, and neonatologists.
CI  - (c) RSNA, 2011.
FAU - Dighe, Manjiri K
AU  - Dighe MK
AD  - Department of Radiology, University of Washington Medical Center, Seattle, WA
      98195-7117, USA.
FAU - Peterson, Suzanne E
AU  - Peterson SE
FAU - Dubinsky, Theodore J
AU  - Dubinsky TJ
FAU - Perkins, Jonathan
AU  - Perkins J
FAU - Cheng, Edith
AU  - Cheng E
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Radiographics
JT  - Radiographics : a review publication of the Radiological Society of North
      America, Inc
JID - 8302501
SB  - IM
MH  - Diagnostic Imaging/*methods
MH  - Fetal Therapies/*methods
MH  - Humans
MH  - Prenatal Diagnosis/*methods
MH  - Radiography, Interventional/*methods
EDAT- 2011/03/19 06:00
MHDA- 2011/08/17 06:00
CRDT- 2011/03/19 06:00
PHST- 2011/03/19 06:00 [entrez]
PHST- 2011/03/19 06:00 [pubmed]
PHST- 2011/08/17 06:00 [medline]
AID - 31/2/511 [pii]
AID - 10.1148/rg.312105108 [doi]
PST - ppublish
SO  - Radiographics. 2011 Mar-Apr;31(2):511-26. doi: 10.1148/rg.312105108.


PMID- 21414696
OWN - NLM
STAT- MEDLINE
DCOM- 20120608
LR  - 20220317
IS  - 1532-2793 (Electronic)
IS  - 0260-6917 (Linking)
VI  - 32
IP  - 3
DP  - 2012 Apr
TI  - The development and evaluation of a 'blended' enquiry based learning model for
      mental health nursing students: "making your experience count".
PG  - 303-8
LID - 10.1016/j.nedt.2011.02.009 [doi]
AB  - To meet the demands required for safe and effective care, nurses must be able to 
      integrate theoretical knowledge with clinical practice (Kohen and Lehman, 2008;
      Polit and Beck, 2008; Shirey, 2006). This should include the ability to adapt
      research in response to changing clinical environments and the changing needs of 
      service users. It is through reflective practice that students develop their
      clinical reasoning and evaluation skills to engage in this process. This paper
      aims to describe the development, implementation and evaluation of a project
      designed to provide a structural approach to the recognition and resolution of
      clinical, theoretical and ethical dilemmas identified by 3rd year undergraduate
      mental health nursing students. This is the first paper to describe the iterative
      process of developing a 'blended' learning model which provides students with an 
      opportunity to experience the process of supervision and to become more
      proficient in using information technology to develop and maintain their clinical
      skills. Three cohorts of student nurses were exposed to various combinations of
      face to face group supervision and a virtual learning environment (VLE) in order 
      to apply their knowledge of good practice guidelines and evidenced-based practice
      to identified clinical issues. A formal qualitative evaluation using
      independently facilitated focus groups was conducted with each student cohort and
      thematically analysed (Miles & Huberman, 1994). The themes that emerged were:
      relevance to practice; facilitation of independent learning; and the discussion
      of clinical issues. The results of this study show that 'blending' face-to-face
      groups with an e-learning component was the most acceptable and effective form of
      delivery which met the needs of students' varied learning styles. Additionally,
      students reported that they were more aware of the importance of clinical
      supervision and of their role as supervisees.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Rigby, Lindsay
AU  - Rigby L
AD  - School of Nursing, Midwifery and Social Work, The University of Manchester, Jean 
      McFarlane Building, Oxford Road, Manchester, M13 9PL, UK.
      Lindsay.Rigby@manchester.ac.uk
FAU - Wilson, Ian
AU  - Wilson I
FAU - Baker, John
AU  - Baker J
FAU - Walton, Tim
AU  - Walton T
FAU - Price, Owen
AU  - Price O
FAU - Dunne, Kate
AU  - Dunne K
FAU - Keeley, Philip
AU  - Keeley P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110317
PL  - Scotland
TA  - Nurse Educ Today
JT  - Nurse education today
JID - 8511379
MH  - Attitude of Health Personnel
MH  - Cohort Studies
MH  - *Computer-Assisted Instruction
MH  - Education, Nursing, Baccalaureate/*methods
MH  - Female
MH  - Focus Groups
MH  - Humans
MH  - Internet
MH  - *Interprofessional Relations
MH  - Male
MH  - *Models, Educational
MH  - Nursing Education Research
MH  - Nursing Evaluation Research
MH  - Nursing Methodology Research
MH  - Psychiatric Nursing/*education
MH  - Students, Nursing/psychology
EDAT- 2011/03/19 06:00
MHDA- 2012/06/09 06:00
CRDT- 2011/03/19 06:00
PHST- 2010/09/08 00:00 [received]
PHST- 2011/01/17 00:00 [revised]
PHST- 2011/02/14 00:00 [accepted]
PHST- 2011/03/19 06:00 [entrez]
PHST- 2011/03/19 06:00 [pubmed]
PHST- 2012/06/09 06:00 [medline]
AID - S0260-6917(11)00052-9 [pii]
AID - 10.1016/j.nedt.2011.02.009 [doi]
PST - ppublish
SO  - Nurse Educ Today. 2012 Apr;32(3):303-8. doi: 10.1016/j.nedt.2011.02.009. Epub
      2011 Mar 17.


PMID- 21414556
OWN - NLM
STAT- MEDLINE
DCOM- 20110630
LR  - 20110318
IS  - 1552-5279 (Electronic)
IS  - 1552-5260 (Linking)
VI  - 7
IP  - 2
DP  - 2011 Mar
TI  - Global issues in drug development for Alzheimer's disease.
PG  - 197-207
LID - 10.1016/j.jalz.2011.01.001 [doi]
AB  - The number of clinical trials for Alzheimer's disease conducted outside the
      United States in a broad array of countries is increasing. As the number of
      compounds ready for clinical testing increases, and as trials become longer and
      more complex, this trend is expected to grow. The cultural and ethical context of
      global clinical trials, potential benefits for those involved, and practical
      approaches to obstacles generated by these global trials were discussed at a
      meeting of the Alzheimer's Association Research Roundtable. Regulatory issues,
      including regional differences in study registration procedures, rules for
      collecting and reporting serious adverse events, requirements for national
      identity of study populations, and regulatory audits were also discussed by
      individuals who are knowledgeable about global clinical trials for Alzheimer's
      disease.
CI  - Copyright (c) 2011 The Alzheimer's Association. Published by Elsevier Inc. All
      rights reserved.
FAU - Doody, Rachelle S
AU  - Doody RS
AD  - Baylor College of Medicine, Houston, TX, USA. rdoody@bcm.edu
FAU - Cole, Patricia E
AU  - Cole PE
FAU - Miller, David S
AU  - Miller DS
FAU - Siemers, Eric
AU  - Siemers E
FAU - Black, Ronald
AU  - Black R
FAU - Feldman, Howard
AU  - Feldman H
FAU - Schindler, Rachel
AU  - Schindler R
FAU - Graham, Stephen
AU  - Graham S
FAU - Heath, Theresa
AU  - Heath T
FAU - Khachaturian, Ara S
AU  - Khachaturian AS
FAU - Evans, Rebecca
AU  - Evans R
FAU - Carrillo, Maria C
AU  - Carrillo MC
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Alzheimers Dement
JT  - Alzheimer's & dementia : the journal of the Alzheimer's Association
JID - 101231978
SB  - IM
MH  - Alzheimer Disease/*drug therapy
MH  - *Clinical Trials as Topic
MH  - Congresses as Topic
MH  - *Drug Discovery
MH  - Humans
EDAT- 2011/03/19 06:00
MHDA- 2011/07/01 06:00
CRDT- 2011/03/19 06:00
PHST- 2011/01/14 00:00 [received]
PHST- 2011/01/26 00:00 [accepted]
PHST- 2011/03/19 06:00 [entrez]
PHST- 2011/03/19 06:00 [pubmed]
PHST- 2011/07/01 06:00 [medline]
AID - S1552-5260(11)00032-X [pii]
AID - 10.1016/j.jalz.2011.01.001 [doi]
PST - ppublish
SO  - Alzheimers Dement. 2011 Mar;7(2):197-207. doi: 10.1016/j.jalz.2011.01.001.


PMID- 21414391
OWN - NLM
STAT- MEDLINE
DCOM- 20111028
LR  - 20141120
IS  - 1879-3169 (Electronic)
IS  - 0378-4274 (Linking)
VI  - 206
IP  - 1
DP  - 2011 Sep 25
TI  - In vitro kinetic interactions of pyridostigmine, physostigmine and soman with
      erythrocyte and muscle acetylcholinesterase from different species.
PG  - 41-6
LID - 10.1016/j.toxlet.2011.03.004 [doi]
AB  - The low effectiveness of atropine and oxime treatment in soman poisoning may be
      enhanced by carbamates pre-treatment. For ethical reasons medical countermeasures
      can only be tested in animal models despite the fact of substantial species
      differences. With this kinetic in vitro study the interactions between
      pyridostigmine, physostigmine and soman with human, Rhesus monkey, swine and
      guinea pig erythrocyte AChE were investigated. In addition, the effect of the
      carbamates on the residual activity and enzyme recovery after soman inhibition
      was examined with erythrocyte and intercostal muscle AChE from these species with
      a dynamic in vitro model with real-time determination of AChE activity. Only
      small to moderate species differences of the inhibition and decarbamylation
      kinetics were recorded. It was possible to show that with erythrocyte and muscle 
      AChE a similar level of protection by carbamates and reactivation after
      discontinuation of the carbamates and soman could be observed. Thus, these data
      indicate that carbamate pre-treatment is expected to protect a critical level of 
      muscle AChE and confirm the presumption that erythrocyte AChE may serve as a
      surrogate for synaptic AChE. Hence, these and previous data fortify the notion
      that erythrocyte AChE is a proper tool for in vitro kinetic studies as well as
      for therapeutic monitoring in experimental and clinical studies.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Herkert, N M
AU  - Herkert NM
AD  - Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstrasse 11, 80937 
      Munich, Germany.
FAU - Thiermann, H
AU  - Thiermann H
FAU - Worek, F
AU  - Worek F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110322
PL  - Netherlands
TA  - Toxicol Lett
JT  - Toxicology letters
JID - 7709027
RN  - 0 (Carbamates)
RN  - 0 (Cholinesterase Inhibitors)
RN  - 96-64-0 (Soman)
RN  - 9U1VM840SP (Physostigmine)
RN  - EC 3.1.1.7 (Acetylcholinesterase)
RN  - KVI301NA53 (Pyridostigmine Bromide)
SB  - IM
MH  - Acetylcholinesterase/*metabolism
MH  - Animals
MH  - Carbamates/chemistry/*pharmacology
MH  - Cholinesterase Inhibitors/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Drug Evaluation, Preclinical
MH  - Drug Interactions
MH  - Erythrocytes/*drug effects/enzymology
MH  - Female
MH  - Guinea Pigs
MH  - Humans
MH  - In Vitro Techniques
MH  - Kinetics
MH  - Macaca mulatta
MH  - Male
MH  - Muscle, Skeletal/*drug effects/enzymology
MH  - Physostigmine/chemistry/pharmacology
MH  - Pyridostigmine Bromide/chemistry/pharmacology
MH  - Soman/*pharmacology
MH  - Species Specificity
MH  - Swine
EDAT- 2011/03/19 06:00
MHDA- 2011/10/29 06:00
CRDT- 2011/03/19 06:00
PHST- 2011/02/22 00:00 [received]
PHST- 2011/03/02 00:00 [accepted]
PHST- 2011/03/19 06:00 [entrez]
PHST- 2011/03/19 06:00 [pubmed]
PHST- 2011/10/29 06:00 [medline]
AID - S0378-4274(11)00101-9 [pii]
AID - 10.1016/j.toxlet.2011.03.004 [doi]
PST - ppublish
SO  - Toxicol Lett. 2011 Sep 25;206(1):41-6. doi: 10.1016/j.toxlet.2011.03.004. Epub
      2011 Mar 22.


PMID- 21413946
OWN - NLM
STAT- MEDLINE
DCOM- 20110719
LR  - 20220409
IS  - 1365-4632 (Electronic)
IS  - 0011-9059 (Linking)
VI  - 50
IP  - 4
DP  - 2011 Apr
TI  - Recruiting underserved populations to dermatologic research: a systematic review.
PG  - 385-95
LID - 10.1111/j.1365-4632.2010.04813.x [doi]
AB  - Recruitment of participants to dermatologic research studies can be challenging, 
      particularly with historically underserved populations. Recruitment of these
      groups is essential to ethical, valid, and useful dermatologic research. This
      article discusses findings from a review of 78 studies that examined factors
      influencing participation in health research studies with an emphasis on
      underserved populations, particularly women and ethnic minorities. The most
      commonly encountered barriers to research participation are mistrust of research,
      lack of access to research programs, and culturally incompetent research design. 
      Motives to participate in research include receipt of benefit from participation,
      perceived opportunities to help others, and culturally competent research design.
      Practical methods for addressing barriers and enhancing research participation
      include culturally competent research design, community-based recruitment, and
      easily understandable informed consent. These factors should be considered when
      recruiting subjects for dermatologic research, especially when recruitment of
      underserved populations is desired. In addition, the literature demonstrates a
      paucity of research among rural residents, infants, and children, as well as
      within clinical dermatologic research.
CI  - (c) 2011 The International Society of Dermatology.
FAU - Spears, Chaya R
AU  - Spears CR
AD  - Departments of Family Medicine, Wake Forest University School of Medicine,
      Winston-Salem, NC 27157, USA.
FAU - Nolan, Bridgit V
AU  - Nolan BV
FAU - O'Neill, Jenna L
AU  - O'Neill JL
FAU - Arcury, Thomas A
AU  - Arcury TA
FAU - Grzywacz, Joseph G
AU  - Grzywacz JG
FAU - Feldman, Steven R
AU  - Feldman SR
LA  - eng
GR  - R21 AI070687/AI/NIAID NIH HHS/United States
GR  - R21 AI 70687/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
PL  - England
TA  - Int J Dermatol
JT  - International journal of dermatology
JID - 0243704
SB  - IM
MH  - Biomedical Research/*methods
MH  - *Dermatology
MH  - Humans
MH  - *Medically Underserved Area
MH  - *Patient Selection
PMC - PMC3645484
MID - NIHMS457632
EDAT- 2011/03/19 06:00
MHDA- 2011/07/20 06:00
CRDT- 2011/03/19 06:00
PHST- 2011/03/19 06:00 [entrez]
PHST- 2011/03/19 06:00 [pubmed]
PHST- 2011/07/20 06:00 [medline]
AID - 10.1111/j.1365-4632.2010.04813.x [doi]
PST - ppublish
SO  - Int J Dermatol. 2011 Apr;50(4):385-95. doi: 10.1111/j.1365-4632.2010.04813.x.


PMID- 21413928
OWN - NLM
STAT- MEDLINE
DCOM- 20110714
LR  - 20220317
IS  - 1095-8355 (Electronic)
IS  - 1065-6995 (Linking)
VI  - 35
IP  - 4
DP  - 2011 Apr
TI  - Transdifferentiation: why and how?
PG  - 373-9
LID - 10.1042/CBI20100445 [doi]
AB  - Cell therapy is based on the replacement of damaged cells in order to restore
      injured tissues. The first consideration is that an abundant source of cells is
      needed; second, these cells should be immunologically compatible with the guest
      and third, there should be no real threat of these cells undergoing malignant
      transformation in the future. Given these requirements, already differentiated
      adult cells or adult stem cells obtained from the body of the patient appear to
      be the ideal candidates to meet all of these demands. The utilization of somatic 
      cells also avoids numerous ethical and political drawbacks and concerns.
      Transdifferentiation is the phenomenon by which an adult differentiated cell
      switches to another differentiated cell. This paper reviews the importance of
      transdifferentiation, discussing the cells that are suitable for this process and
      the methods currently employed to induce the change in cell type.
FAU - Peran, Macarena
AU  - Peran M
AD  - Department of Human Anatomy and Embryology, University of Granada, 18012 Granada,
      Spain. mperan@ugr.es
FAU - Marchal, Juan Antonio
AU  - Marchal JA
FAU - Rodriguez-Serrano, Fernando
AU  - Rodriguez-Serrano F
FAU - Alvarez, Pablo
AU  - Alvarez P
FAU - Aranega, Antonia
AU  - Aranega A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Cell Biol Int
JT  - Cell biology international
JID - 9307129
SB  - IM
MH  - Adult Stem Cells/*cytology
MH  - Animals
MH  - Cell Culture Techniques/methods
MH  - *Cell Transdifferentiation
MH  - Cell- and Tissue-Based Therapy
MH  - Humans
MH  - Stem Cell Transplantation
EDAT- 2011/03/19 06:00
MHDA- 2011/07/16 06:00
CRDT- 2011/03/19 06:00
PHST- 2011/03/19 06:00 [entrez]
PHST- 2011/03/19 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
AID - CBI20100445 [pii]
AID - 10.1042/CBI20100445 [doi]
PST - ppublish
SO  - Cell Biol Int. 2011 Apr;35(4):373-9. doi: 10.1042/CBI20100445.


PMID- 21412638
OWN - NLM
STAT- MEDLINE
DCOM- 20110830
LR  - 20220310
IS  - 1518-8345 (Electronic)
IS  - 0104-1169 (Linking)
VI  - 19
IP  - 1
DP  - 2011 Jan-Feb
TI  - Nurses' clinical practice in primary care: a process under construction.
PG  - 123-30
LID - S0104-11692011000100017 [pii]
AB  - This study aims to present the re-signification process of the meanings of
      nurses' clinical practice in primary care from the perspective of extended clinic
      and permanent education. An intervention research was carried out with the
      approval of an ethics committee. Nine nurses participated in reflection groups
      from September to December 2008 in Ribeirao Preto-SP-Brazil. The redefinition
      process of the meanings proposed by the institutional analysis was mapped. The
      results point out that the nurses perceive differences in clinical work, by
      acknowledging the sense of user-centered clinical practice; daily limits and
      tensions and the need for support from managers and the team to deal with users' 
      problems and situations. They identify the necessity to open space in the
      schedule to do that. It was concluded that nurses' clinical practice is being
      consolidated, and that collective analysis processes permit learning and the
      reconstruction of practices.
FAU - Matumoto, Silvia
AU  - Matumoto S
AD  - Escola de Enfermagem de Ribeirao Preto, Universidade de Sao Paulo, Brazil.
      smatumoto@eerp.usp.br
FAU - Fortuna, Cinira Magali
AU  - Fortuna CM
FAU - Kawata, Lauren Suemi
AU  - Kawata LS
FAU - Mishima, Silvana Martins
AU  - Mishima SM
FAU - Pereira, Maria Jose Bistafa
AU  - Pereira MJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Brazil
TA  - Rev Lat Am Enfermagem
JT  - Revista latino-americana de enfermagem
JID - 9420934
MH  - Humans
MH  - Nursing Process
MH  - *Primary Care Nursing
EDAT- 2011/03/18 06:00
MHDA- 2011/08/31 06:00
CRDT- 2011/03/18 06:00
PHST- 2009/10/14 00:00 [received]
PHST- 2010/07/16 00:00 [accepted]
PHST- 2011/03/18 06:00 [entrez]
PHST- 2011/03/18 06:00 [pubmed]
PHST- 2011/08/31 06:00 [medline]
AID - S0104-11692011000100017 [pii]
AID - 10.1590/s0104-11692011000100017 [doi]
PST - ppublish
SO  - Rev Lat Am Enfermagem. 2011 Jan-Feb;19(1):123-30. doi:
      10.1590/s0104-11692011000100017.


PMID- 21412629
OWN - NLM
STAT- MEDLINE
DCOM- 20110830
LR  - 20190608
IS  - 1518-8345 (Electronic)
IS  - 0104-1169 (Linking)
VI  - 19
IP  - 1
DP  - 2011 Jan-Feb
TI  - Predictive validity of the Braden scale for pressure ulcer risk in critical care 
      patients.
PG  - 50-7
LID - S0104-11692011000100008 [pii]
AB  - This methodological study aimed to evaluate the predictive validity of the Braden
      scale in critical care patients. The study was conducted in four intensive care
      units of a general private hospital. After approval of the project by the
      Hospital Ethics Committee, during six months, adult patients admitted to ICUs
      with a Braden score <18 and without PU were assessed upon admission and at
      48-hours intervals as long as the patient remained at risk or until the
      development of PU, patients' discharge, death or transfer from the ICU. The
      cut-off scores of the Braden scale in the first, second and third assessments
      were 12, 13 and 13, respectively. Sensitivity was 85.7%, 71.4% and 71.4% and
      specificity was 64.6%, 81.5% and 83.1%, respectively. Areas under the ROC curves 
      revealed very good accuracy for the cut-off scores. The Braden cut-off score 13
      in the third assessment showed the best predictive performance in critical care
      patients.
FAU - Serpa, Leticia Faria
AU  - Serpa LF
AD  - Escola de Enfermagem, Universidade de Sao Paulo, SP, Brazil. lfserpa@uol.com.br
FAU - Santos, Vera Lucia Conceicao de Gouveia
AU  - Santos VL
FAU - Campanili, Ticiane Carolina Goncalves Faustino
AU  - Campanili TC
FAU - Queiroz, Moelisa
AU  - Queiroz M
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - Rev Lat Am Enfermagem
JT  - Revista latino-americana de enfermagem
JID - 9420934
MH  - Critical Care
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Pressure Ulcer/*diagnosis/epidemiology
MH  - Reproducibility of Results
MH  - Risk Assessment
MH  - Sensitivity and Specificity
EDAT- 2011/03/18 06:00
MHDA- 2011/08/31 06:00
CRDT- 2011/03/18 06:00
PHST- 2009/08/04 00:00 [received]
PHST- 2010/07/16 00:00 [accepted]
PHST- 2011/03/18 06:00 [entrez]
PHST- 2011/03/18 06:00 [pubmed]
PHST- 2011/08/31 06:00 [medline]
AID - S0104-11692011000100008 [pii]
AID - 10.1590/s0104-11692011000100008 [doi]
PST - ppublish
SO  - Rev Lat Am Enfermagem. 2011 Jan-Feb;19(1):50-7. doi:
      10.1590/s0104-11692011000100008.


PMID- 21412306
OWN - NLM
STAT- MEDLINE
DCOM- 20110406
LR  - 20110317
IS  - 1476-4687 (Electronic)
IS  - 0028-0836 (Linking)
VI  - 471
IP  - 7338
DP  - 2011 Mar 17
TI  - Hidden toll of embryo ethics war.
PG  - 279
LID - 10.1038/471279a [doi]
FAU - Ledford, Heidi
AU  - Ledford H
LA  - eng
PT  - News
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
SB  - IM
MH  - Blastocyst/cytology
MH  - Blastomeres/cytology
MH  - Cell Line
MH  - Clinical Trials as Topic/economics
MH  - Corneal Dystrophies, Hereditary/therapy
MH  - *Embryonic Stem Cells/cytology
MH  - Humans
MH  - Induced Pluripotent Stem Cells/cytology
MH  - National Institutes of Health (U.S.)
MH  - Stem Cell Research/economics/*ethics/*legislation & jurisprudence
MH  - Tissue Banks
MH  - United States
EDAT- 2011/03/18 06:00
MHDA- 2011/04/07 06:00
CRDT- 2011/03/18 06:00
PHST- 2011/03/18 06:00 [entrez]
PHST- 2011/03/18 06:00 [pubmed]
PHST- 2011/04/07 06:00 [medline]
AID - 471279a [pii]
AID - 10.1038/471279a [doi]
PST - ppublish
SO  - Nature. 2011 Mar 17;471(7338):279. doi: 10.1038/471279a.


PMID- 21412253
OWN - NLM
STAT- MEDLINE
DCOM- 20110519
LR  - 20211020
IS  - 1474-1768 (Electronic)
IS  - 1474-175X (Linking)
VI  - 11
IP  - 4
DP  - 2011 Apr
TI  - The Bio-PIN: a concept to improve biobanking.
PG  - 303-8
LID - 10.1038/nrc3022 [doi]
AB  - A new biobanking method is proposed, wherein samples and associated data would be
      deposited anonymously and labelled using a PIN code that is produced on the basis
      of personal biological characteristics, such as single nucleotide polymorphisms. 
      The code would be the 'Bio-PIN' to uniquely distinguish the sample depositors,
      plus their samples and data. This method could help to diminish several
      long-discussed ethical, legal and societal problems in biobanking regarding
      privacy, informed consent, autonomy, data security and public trust.
FAU - Nietfeld, J J
AU  - Nietfeld JJ
AD  - Department of Pathology, University Medical Center Utrecht, Heidelberglaan 100,
      Utrecht 3584CX, The Netherlands. J.J.Nietfeld@umcutrecht.nl
FAU - Sugarman, Jeremy
AU  - Sugarman J
FAU - Litton, Jan-Eric
AU  - Litton JE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110317
PL  - England
TA  - Nat Rev Cancer
JT  - Nature reviews. Cancer
JID - 101124168
SB  - IM
CIN - Nat Rev Cancer. 2011 Dec;11(12):895; author reply 895. PMID: 22051861
MH  - Biological Specimen Banks/*ethics/*standards
MH  - *Computer Security
MH  - Humans
MH  - *Patient Identification Systems
MH  - Patient Rights
EDAT- 2011/03/18 06:00
MHDA- 2011/05/20 06:00
CRDT- 2011/03/18 06:00
PHST- 2011/03/18 06:00 [entrez]
PHST- 2011/03/18 06:00 [pubmed]
PHST- 2011/05/20 06:00 [medline]
AID - nrc3022 [pii]
AID - 10.1038/nrc3022 [doi]
PST - ppublish
SO  - Nat Rev Cancer. 2011 Apr;11(4):303-8. doi: 10.1038/nrc3022. Epub 2011 Mar 17.


PMID- 21411427
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20110317
IS  - 1048-2911 (Print)
IS  - 1048-2911 (Linking)
VI  - 21
IP  - 1
DP  - 2011
TI  - The differing perspectives of workers and occupational medicine physicians on the
      ethical, legal and social issues of genetic testing in the workplace.
PG  - 89-102
LID - 10.2190/NS.21.1.j [doi]
AB  - Genetic testing in the workplace holds the promise of improving worker health but
      also raises ethical, legal, and social issues. In considering such testing, it is
      critical to understand the perspectives of workers, who are most directly
      affected by it, and occupational health professionals, who are often directly
      involved in its implementation. Therefore, a series of focus groups of unionized 
      workers (n=25) and occupational medicine physicians (n=23) was conducted. The
      results demonstrated strikingly different perspectives of workers and physicians 
      in several key areas, including the goals and appropriateness of genetic testing,
      and methods to minimize its risks. In general, workers were guided by a profound 
      mistrust of the employer, physician, and government, while physicians were guided
      primarily by scientific and medical concerns, and, in many cases, by the business
      concerns distrusted by the workers.
FAU - Brandt-Rauf, Sherry I
AU  - Brandt-Rauf SI
FAU - Brandt-Rauf, Elka
AU  - Brandt-Rauf E
FAU - Gershon, Robyn
AU  - Gershon R
FAU - Brandt-Rauf, Paul W
AU  - Brandt-Rauf PW
LA  - eng
GR  - R01-OH04192/OH/NIOSH CDC HHS/United States
GR  - R03-HG03682/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - New Solut
JT  - New solutions : a journal of environmental and occupational health policy : NS
JID - 9100937
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Attitude of Health Personnel
MH  - Chi-Square Distribution
MH  - Female
MH  - Focus Groups
MH  - Genetic Testing/*ethics/*legislation & jurisprudence
MH  - Humans
MH  - Labor Unions
MH  - Male
MH  - Middle Aged
MH  - Occupational Medicine/*ethics/*legislation & jurisprudence
MH  - Physicians/*psychology
MH  - *Workplace
EDAT- 2011/03/18 06:00
MHDA- 2011/06/29 06:00
CRDT- 2011/03/18 06:00
PHST- 2011/03/18 06:00 [entrez]
PHST- 2011/03/18 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
AID - HNUW280711271K33 [pii]
AID - 10.2190/NS.21.1.j [doi]
PST - ppublish
SO  - New Solut. 2011;21(1):89-102. doi: 10.2190/NS.21.1.j.


PMID- 21411284
OWN - NLM
STAT- MEDLINE
DCOM- 20111027
LR  - 20220409
IS  - 1878-5921 (Electronic)
IS  - 0895-4356 (Linking)
VI  - 64
IP  - 9
DP  - 2011 Sep
TI  - Systematic review of stepped wedge cluster randomized trials shows that design is
      particularly used to evaluate interventions during routine implementation.
PG  - 936-48
LID - 10.1016/j.jclinepi.2010.12.003 [doi]
AB  - OBJECTIVE: To describe the application of the stepped wedge cluster randomized
      controlled trial (CRCT) design. STUDY DESIGN AND SETTING: Systematic review. We
      searched Medline, Embase, PsycINFO, HMIC, CINAHL, Cochrane Library, Web of
      Knowledge, and Current Controlled Trials Register for articles published up to
      January 2010. Stepped wedge CRCTs from all fields of research were included. Two 
      authors independently reviewed and extracted data from the studies. RESULTS:
      Twenty-five studies were included in the review. Motivations for using the design
      included ethical, logistical, financial, social, and political acceptability and 
      methodological reasons. Most studies were evaluating an intervention during
      routine implementation. For most of the included studies, there was also a belief
      or empirical evidence suggesting that the intervention would do more good than
      harm. There was variation in data analysis methods and insufficient quality of
      reporting. CONCLUSIONS: The stepped wedge CRCT design has been mainly used for
      evaluating interventions during routine implementation, particularly for
      interventions that have been shown to be effective in more controlled research
      settings, or where there is lack of evidence of effectiveness but there is a
      strong belief that they will do more good than harm. There is need for consistent
      data analysis and reporting.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Mdege, Noreen D
AU  - Mdege ND
AD  - York Trials Unit, Department of Health Sciences, University of York, Heslington, 
      York YO10 5DD, UK. nm619@york.ac.uk
FAU - Man, Mei-See
AU  - Man MS
FAU - Taylor Nee Brown, Celia A
AU  - Taylor Nee Brown CA
FAU - Torgerson, David J
AU  - Torgerson DJ
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20110316
PL  - United States
TA  - J Clin Epidemiol
JT  - Journal of clinical epidemiology
JID - 8801383
SB  - IM
CIN - J Clin Epidemiol. 2014 Jul;67(7):833-4. PMID: 24751180
CIN - J Clin Epidemiol. 2014 Jul;67(7):831-3. PMID: 24774471
MH  - Cluster Analysis
MH  - Comparative Effectiveness Research
MH  - Cross-Over Studies
MH  - Data Interpretation, Statistical
MH  - Databases, Bibliographic
MH  - Humans
MH  - Randomized Controlled Trials as Topic/ethics/*methods/statistics & numerical data
MH  - *Research Design
MH  - Therapeutic Equipoise
MH  - Time Factors
EDAT- 2011/03/18 06:00
MHDA- 2011/10/28 06:00
CRDT- 2011/03/18 06:00
PHST- 2010/05/06 00:00 [received]
PHST- 2010/11/26 00:00 [revised]
PHST- 2010/12/03 00:00 [accepted]
PHST- 2011/03/18 06:00 [entrez]
PHST- 2011/03/18 06:00 [pubmed]
PHST- 2011/10/28 06:00 [medline]
AID - S0895-4356(10)00435-X [pii]
AID - 10.1016/j.jclinepi.2010.12.003 [doi]
PST - ppublish
SO  - J Clin Epidemiol. 2011 Sep;64(9):936-48. doi: 10.1016/j.jclinepi.2010.12.003.
      Epub 2011 Mar 16.


PMID- 21411001
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211020
IS  - 1472-698X (Electronic)
IS  - 1472-698X (Linking)
VI  - 11 Suppl 1
DP  - 2011 Mar 9
TI  - Building partnerships towards strengthening Makerere University College of Health
      Sciences: a stakeholder and sustainability analysis.
PG  - S14
LID - 10.1186/1472-698X-11-S1-S14 [doi]
AB  - BACKGROUND: Partnerships and networking are important for an institution of
      higher learning like Makerere University College of Health Sciences (MakCHS) to
      be competitive and sustainable. METHODS: A stakeholder and sustainability
      analysis of 25 key informant interviews was conducted among past, current and
      potential stakeholders of MakCHS to obtain their perspectives and contributions
      to sustainability of the College in its role to improve health outcomes. RESULTS:
      The College has multiple internal and external stakeholders. Stakeholders from
      Uganda wanted the College to use its enormous academic capacity to fulfil its
      vision, take initiative, and be innovative in conducting more research and
      training relevant to the country's health needs. Many stakeholders felt that the 
      initiative for collaboration currently came more from the stakeholders than the
      College. External stakeholders felt that MakCHS was insufficiently marketing
      itself and not directly engaging the private sector or Parliament. Stakeholders
      also identified the opportunity for MakCHS to embrace information technology in
      research, learning and training, and many also wanted MakCHS to start leadership 
      and management training programmes in health systems. The need for MakCHS to be
      more vigorous in training to enhance professionalism and ethical conduct was also
      identified. DISCUSSION: As a constituent of a public university, MakCHS has
      relied on public funding, which has been inadequate to fulfill its mission.
      Broader networking, marketing to mobilize resources, and providing strong
      leadership and management support to inspire confidence among its current and
      potential stakeholders will be essential to MakCHS' further growth. MakCHS'
      relevance is hinged on generating research knowledge for solving the country's
      contemporary health problems and starting relevant programs and embracing
      technologies. It should share new knowledge widely through publications and other
      forms of dissemination. Whether institutional leadership is best in the hands of 
      academicians or professional managers is a debatable matter. CONCLUSIONS: This
      study points towards the need for MakCHS and other African public universities to
      build a broad network of partnerships to strengthen their operations, relevance, 
      and sustainability. Conducting stakeholder and sustainability analyses are
      instructive toward this end, and have provided information and perspectives on
      how to make long-range informed choices for success.
FAU - Okui, Olico
AU  - Okui O
AD  - Department of Health Policy, Planning and Management, School of Public Health,
      Makerere University College of Health Sciences P,O,Box 7072, Kampala, Uganda.
      ookui@musph.ac.ug.
FAU - Ayebare, Elizabeth
AU  - Ayebare E
FAU - Chalo, Rose Nabirye
AU  - Chalo RN
FAU - Pariyo, George W
AU  - Pariyo GW
FAU - Groves, Sara
AU  - Groves S
FAU - Peters, David H
AU  - Peters DH
LA  - eng
PT  - Journal Article
DEP - 20110309
PL  - England
TA  - BMC Int Health Hum Rights
JT  - BMC international health and human rights
JID - 101088678
PMC - PMC3059473
EDAT- 2011/03/18 06:00
MHDA- 2011/03/18 06:01
CRDT- 2011/03/18 06:00
PHST- 2011/03/18 06:00 [entrez]
PHST- 2011/03/18 06:00 [pubmed]
PHST- 2011/03/18 06:01 [medline]
AID - 1472-698X-11-S1-S14 [pii]
AID - 10.1186/1472-698X-11-S1-S14 [doi]
PST - epublish
SO  - BMC Int Health Hum Rights. 2011 Mar 9;11 Suppl 1:S14. doi:
      10.1186/1472-698X-11-S1-S14.


PMID- 21410866
OWN - NLM
STAT- MEDLINE
DCOM- 20110531
LR  - 20110317
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 11
IP  - 1
DP  - 2011 Apr
TI  - Public health ethics and the law of the land.
PG  - ii-iii
LID - 10.1111/j.1471-8847.2011.00298.x [doi]
FAU - Schuklenk, Udo
AU  - Schuklenk U
LA  - eng
PT  - Editorial
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
SB  - IM
MH  - *Criminal Law/trends
MH  - *Cultural Characteristics
MH  - HIV Infections/epidemiology/*prevention & control/transmission
MH  - *Homosexuality, Male
MH  - Humans
MH  - Jamaica
MH  - Male
MH  - Prevalence
MH  - *Public Health/ethics/legislation & jurisprudence
MH  - Terminology as Topic
EDAT- 2011/03/18 06:00
MHDA- 2011/06/01 06:00
CRDT- 2011/03/18 06:00
PHST- 2011/03/18 06:00 [entrez]
PHST- 2011/03/18 06:00 [pubmed]
PHST- 2011/06/01 06:00 [medline]
AID - 10.1111/j.1471-8847.2011.00298.x [doi]
PST - ppublish
SO  - Dev World Bioeth. 2011 Apr;11(1):ii-iii. doi: 10.1111/j.1471-8847.2011.00298.x.


PMID- 21410849
OWN - NLM
STAT- MEDLINE
DCOM- 20110519
LR  - 20110317
IS  - 1365-3156 (Electronic)
IS  - 1360-2276 (Linking)
VI  - 16
IP  - 4
DP  - 2011 Apr
TI  - Double ethical review of North-South collaborative clinical research: hidden
      paternalism or real partnership?
PG  - 527-30
LID - 10.1111/j.1365-3156.2011.02732.x [doi]
AB  - Despite their universal character, the ethical principles governing clinical
      research need to be translated into procedures and practices, which will vary
      among countries and regions because of differences in local cultural norms and in
      the available resources. Double ethical review, by which a research protocol is
      submitted for ethical clearance both in the country or countries where the
      research takes place and in the country of the sponsor or funding agency, will
      then help ensure that all relevant perspectives are taken into account. In
      addition, a geographically and culturally close ethics committee can do a much
      better informed and comprehensive assessment of the respective skills of the
      clinical sites and of the sponsor. But the practical implementation of double
      ethical review can bring significant difficulties and delays, especially in
      multi-site and multi-country researches. Currently, most ethics committees do not
      proactively seek communication with others evaluating the same research protocol 
      in different socio-economical and cultural contexts, so in practice there is no
      mutual learning process. Proactive communication would help to build
      collaborative partnership among ethical bodies, promoting common practices and
      resolving conflicting opinions.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Ravinetto, Raffaella
AU  - Ravinetto R
AD  - Clinical Trials Unit, Institute of Tropical Medicine Prince Leopold, Antwerp,
      Belgium. rravinetto@itg.be
FAU - Buve, Anne
AU  - Buve A
FAU - Halidou, Tinto
AU  - Halidou T
FAU - Lutumba, Pascal
AU  - Lutumba P
FAU - Talisuna, Ambrose
AU  - Talisuna A
FAU - Juffrie, Mohammad
AU  - Juffrie M
FAU - D'Alessandro, Umberto
AU  - D'Alessandro U
FAU - Boelaert, Marleen
AU  - Boelaert M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110201
PL  - England
TA  - Trop Med Int Health
JT  - Tropical medicine & international health : TM & IH
JID - 9610576
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Clinical Trials as Topic/ethics
MH  - Cooperative Behavior
MH  - *Ethical Review
MH  - Ethics Committees
MH  - Humans
MH  - *International Cooperation
MH  - *Paternalism/ethics
EDAT- 2011/03/18 06:00
MHDA- 2011/05/20 06:00
CRDT- 2011/03/18 06:00
PHST- 2011/03/18 06:00 [entrez]
PHST- 2011/03/18 06:00 [pubmed]
PHST- 2011/05/20 06:00 [medline]
AID - 10.1111/j.1365-3156.2011.02732.x [doi]
PST - ppublish
SO  - Trop Med Int Health. 2011 Apr;16(4):527-30. doi:
      10.1111/j.1365-3156.2011.02732.x. Epub 2011 Feb 1.


PMID- 21410789
OWN - NLM
STAT- MEDLINE
DCOM- 20110527
LR  - 20110317
IS  - 1365-2796 (Electronic)
IS  - 0954-6820 (Linking)
VI  - 269
IP  - 4
DP  - 2011 Apr
TI  - Commentary: systems, rules and the costs of being ethical--a response to D.
      Chalmers and to S. Whitney and C. Schneider.
PG  - 403-6
LID - 10.1111/j.1365-2796.2011.02351_3.x [doi]
FAU - Holm, S
AU  - Holm S
AD  - Centre for Social Ethics and Policy, School of Law, University of Manchester,
      Manchester, UK. Soren.holm@manchester.ac.uk
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - England
TA  - J Intern Med
JT  - Journal of internal medicine
JID - 8904841
SB  - IM
CON - J Intern Med. 2011 Apr;269(4):392-5. PMID: 21410787
CON - J Intern Med. 2011 Apr;269(4):396-402. PMID: 21410788
MH  - Biomedical Research/*ethics/legislation & jurisprudence
MH  - Ethical Review/*legislation & jurisprudence
MH  - Ethics Committees, Research/ethics/legislation & jurisprudence
MH  - Ethics, Research
MH  - Humans
MH  - Informed Consent/ethics/legislation & jurisprudence
EDAT- 2011/03/18 06:00
MHDA- 2011/05/28 06:00
CRDT- 2011/03/18 06:00
PHST- 2011/03/18 06:00 [entrez]
PHST- 2011/03/18 06:00 [pubmed]
PHST- 2011/05/28 06:00 [medline]
AID - 10.1111/j.1365-2796.2011.02351_3.x [doi]
PST - ppublish
SO  - J Intern Med. 2011 Apr;269(4):403-6. doi: 10.1111/j.1365-2796.2011.02351_3.x.


PMID- 21410788
OWN - NLM
STAT- MEDLINE
DCOM- 20110527
LR  - 20220316
IS  - 1365-2796 (Electronic)
IS  - 0954-6820 (Linking)
VI  - 269
IP  - 4
DP  - 2011 Apr
TI  - Viewpoint: a method to estimate the cost in lives of ethics board review of
      biomedical research.
PG  - 396-402
LID - 10.1111/j.1365-2796.2011.02351_2.x [doi]
FAU - Whitney, S N
AU  - Whitney SN
AD  - Department of Family and Community Medicine, Baylor College of Medicine, Houston,
      TX 77098, USA. swhitney@bcm.edu
FAU - Schneider, C E
AU  - Schneider CE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Intern Med
JT  - Journal of internal medicine
JID - 8904841
SB  - IM
CIN - J Intern Med. 2011 Apr;269(4):403-6. PMID: 21410789
MH  - Biomedical Research/*ethics/legislation & jurisprudence
MH  - Clinical Trials as Topic/ethics/legislation & jurisprudence
MH  - Ethical Review/legislation & jurisprudence
MH  - Ethics Committees, Research/*ethics/legislation & jurisprudence
MH  - Humans
MH  - Models, Theoretical
MH  - Survival Analysis
EDAT- 2011/03/18 06:00
MHDA- 2011/05/28 06:00
CRDT- 2011/03/18 06:00
PHST- 2011/03/18 06:00 [entrez]
PHST- 2011/03/18 06:00 [pubmed]
PHST- 2011/05/28 06:00 [medline]
AID - 10.1111/j.1365-2796.2011.02351_2.x [doi]
PST - ppublish
SO  - J Intern Med. 2011 Apr;269(4):396-402. doi: 10.1111/j.1365-2796.2011.02351_2.x.


PMID- 21410787
OWN - NLM
STAT- MEDLINE
DCOM- 20110527
LR  - 20110317
IS  - 1365-2796 (Electronic)
IS  - 0954-6820 (Linking)
VI  - 269
IP  - 4
DP  - 2011 Apr
TI  - Viewpoint: are the research ethics committees working in the best interests of
      participants in an increasingly globalized research environment?
PG  - 392-5
LID - 10.1111/j.1365-2796.2011.02351_1.x [doi]
FAU - Chalmers, D
AU  - Chalmers D
AD  - Faculty of Law, University of Tasmania, Hobart, Tas., Australia.
      Don.Chalmers@utas.edu.au
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Intern Med
JT  - Journal of internal medicine
JID - 8904841
SB  - IM
CIN - J Intern Med. 2011 Apr;269(4):403-6. PMID: 21410789
MH  - Biomedical Research/ethics/*trends
MH  - Ethics Committees, Research/*trends
MH  - Ethics, Research
MH  - Humans
MH  - Internationality
MH  - Multicenter Studies as Topic/ethics/trends
EDAT- 2011/03/18 06:00
MHDA- 2011/05/28 06:00
CRDT- 2011/03/18 06:00
PHST- 2011/03/18 06:00 [entrez]
PHST- 2011/03/18 06:00 [pubmed]
PHST- 2011/05/28 06:00 [medline]
AID - 10.1111/j.1365-2796.2011.02351_1.x [doi]
PST - ppublish
SO  - J Intern Med. 2011 Apr;269(4):392-5. doi: 10.1111/j.1365-2796.2011.02351_1.x.


PMID- 21410781
OWN - NLM
STAT- MEDLINE
DCOM- 20110527
LR  - 20110317
IS  - 1365-2796 (Electronic)
IS  - 0954-6820 (Linking)
VI  - 269
IP  - 4
DP  - 2011 Apr
TI  - Is medical ethics doing its job?
PG  - 366-9
LID - 10.1111/j.1365-2796.2011.02348.x [doi]
FAU - Hansson, M G
AU  - Hansson MG
AD  - Centre for Research Ethics and Bioethics, Uppsala University, Uppsala, UK.
FAU - Chadwick, R
AU  - Chadwick R
LA  - eng
PT  - Introductory Journal Article
PL  - England
TA  - J Intern Med
JT  - Journal of internal medicine
JID - 8904841
SB  - IM
MH  - Bioethical Issues
MH  - Costs and Cost Analysis/statistics & numerical data
MH  - Ethical Review/economics
MH  - *Ethics, Medical
MH  - Ethics, Research
MH  - Humans
EDAT- 2011/03/18 06:00
MHDA- 2011/05/28 06:00
CRDT- 2011/03/18 06:00
PHST- 2011/03/18 06:00 [entrez]
PHST- 2011/03/18 06:00 [pubmed]
PHST- 2011/05/28 06:00 [medline]
AID - 10.1111/j.1365-2796.2011.02348.x [doi]
PST - ppublish
SO  - J Intern Med. 2011 Apr;269(4):366-9. doi: 10.1111/j.1365-2796.2011.02348.x.


PMID- 21410748
OWN - NLM
STAT- MEDLINE
DCOM- 20111017
LR  - 20110610
IS  - 1467-7717 (Electronic)
IS  - 0361-3666 (Linking)
VI  - 35
IP  - 3
DP  - 2011 Jul
TI  - Establishing moral bearings: ethics and expatriate health care professionals in
      humanitarian work.
PG  - 606-22
LID - 10.1111/j.1467-7717.2011.01232.x [doi]
AB  - Expatriate health care professionals frequently participate in international
      responses to natural disasters and humanitarian emergencies. This field of
      practice presents important clinical, logistical and ethical challenges for
      clinicians. This paper considers the ethics of health care practice in
      humanitarian contexts. It examines features that contribute to forming the moral 
      landscape of humanitarian work, and discusses normative guidelines and approaches
      that are relevant for this work. These tools and frameworks provide important
      ethics resources for humanitarian settings. Finally, it elaborates a set of
      questions that can aid health care professionals as they analyse ethical issues
      that they experience in the field. The proposed process can assist clinicians as 
      they seek to establish their moral bearings in situations of ethical complexity
      and uncertainty. Identifying and developing ethics resources and vocabulary for
      clinical practice in humanitarian work will help health care professionals
      provide ethically sound care to patients and communities.
CI  - (c) 2011 The Author(s). Disasters (c) Overseas Development Institute, 2011.
FAU - Hunt, Matthew R
AU  - Hunt MR
AD  - Centre for Research on Ethics, University of Montreal, Canada.
      1matthew.hunt@gmail.com
LA  - eng
PT  - Journal Article
DEP - 20110316
PL  - England
TA  - Disasters
JT  - Disasters
JID - 7702072
SB  - IM
MH  - *Altruism
MH  - Delivery of Health Care/*ethics
MH  - Disaster Planning
MH  - Disasters
MH  - Humans
MH  - *Morals
MH  - Relief Work/*ethics
EDAT- 2011/03/18 06:00
MHDA- 2011/10/18 06:00
CRDT- 2011/03/18 06:00
PHST- 2011/03/18 06:00 [entrez]
PHST- 2011/03/18 06:00 [pubmed]
PHST- 2011/10/18 06:00 [medline]
AID - 10.1111/j.1467-7717.2011.01232.x [doi]
PST - ppublish
SO  - Disasters. 2011 Jul;35(3):606-22. doi: 10.1111/j.1467-7717.2011.01232.x. Epub
      2011 Mar 16.


PMID- 21410579
OWN - NLM
STAT- MEDLINE
DCOM- 20111216
LR  - 20191210
IS  - 1365-2524 (Electronic)
IS  - 0966-0410 (Linking)
VI  - 19
IP  - 5
DP  - 2011 Sep
TI  - Counselling teenage girls on problems related to the 'protection of family
      honour' from the perspective of school nurses and counsellors.
PG  - 476-84
LID - 10.1111/j.1365-2524.2011.00993.x [doi]
AB  - Approximately 1,500 young immigrant women living in Sweden sought help from
      various public organisations during 2004 due to problems related to Protection of
      Family Honour (PFH). Often they seek help from school nurses and counsellors.
      Information on how the school nurses and counsellors manage this complex PFH
      phenomenon is limited in Sweden. The aim was to generate a theoretical model that
      illuminates the experiences of school counsellors and school nurses counselling
      teenage girls, who worry about problems related to protection of family honour.
      Data were collected through individual interviews of the school welfare staff.
      The study subjects included welfare staff from six upper-secondary schools
      consisting of four nurses and six counsellors. Grounded theory methods were used 
      to generate new knowledge as this is a new field of research. The staff's main
      goal was to provide the best support and help for the teenage girls. In addition,
      they wanted to be true to their professional ethics and values. However, this was
      difficult and created professional dilemmas because some teenage girls prevented 
      them from doing what they thought was needed to support the teenage girls and
      protect them from violence. As a result, staff sometimes felt hampered, unable to
      help or able to help only in ways hidden from the teenage girls' families.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Alizadeh, Venus
AU  - Alizadeh V
AD  - Centre of Family and Community Medicine, Karolinska Institutet, Huddinge, Sweden,
      Linkoping University, Linkoping, Sweden. venus.alizadeh@sll.se
FAU - Tornkvist, Lena
AU  - Tornkvist L
FAU - Hylander, Ingrid
AU  - Hylander I
LA  - eng
PT  - Journal Article
DEP - 20110316
PL  - England
TA  - Health Soc Care Community
JT  - Health & social care in the community
JID - 9306359
SB  - IM
MH  - Adolescent
MH  - Adolescent Behavior/*psychology
MH  - Conflict, Psychological
MH  - Culture
MH  - *Directive Counseling
MH  - Emigrants and Immigrants
MH  - *Family Relations
MH  - Female
MH  - Humans
MH  - Models, Theoretical
MH  - *Patient Satisfaction
MH  - Qualitative Research
MH  - *School Nursing
MH  - *Social Identification
MH  - Sweden
EDAT- 2011/03/18 06:00
MHDA- 2011/12/17 06:00
CRDT- 2011/03/18 06:00
PHST- 2011/03/18 06:00 [entrez]
PHST- 2011/03/18 06:00 [pubmed]
PHST- 2011/12/17 06:00 [medline]
AID - 10.1111/j.1365-2524.2011.00993.x [doi]
PST - ppublish
SO  - Health Soc Care Community. 2011 Sep;19(5):476-84. doi:
      10.1111/j.1365-2524.2011.00993.x. Epub 2011 Mar 16.


PMID- 21410107
OWN - NLM
STAT- MEDLINE
DCOM- 20110727
LR  - 20161125
IS  - 1938-2375 (Electronic)
IS  - 1542-8877 (Linking)
VI  - 42
IP  - 2
DP  - 2011 Mar-Apr
TI  - Adjunctive bevacizumab in patients undergoing Ahmed valve implantation: a pilot
      study.
PG  - 132-7
LID - 10.3928/15428877-20110316-02 [doi]
AB  - BACKGROUND AND OBJECTIVE: To report on preliminary findings of adjunctive
      subconjunctival bevacizumab (SCB) injections in patients undergoing Ahmed valve
      implantation (AVI) (New World Medical, Rancho Cucamonga, CA). PATIENTS AND
      METHODS: The study was approved by the institution's ethics committee. Patients
      were prospectively recruited during a 1-month period and randomized to receive
      AVI with postoperative SCB (days 1 and 7, n = 7) or AVI without SCB (n = 6).
      RESULTS: Baseline intraocular pressure (IOP) in the treatment (AVI+SCB) group was
      19.4 +/- 8.6 mm Hg, whereas baseline IOP in the control (AVI) group was 32.1 +/- 
      17.7 mm Hg (P = .119). Final IOP was 13.8 mm Hg (n = 7) for the treatment group
      and 12.7 mm Hg for the control group (n = 5, P = .790). One eye in the control
      group required further glaucoma intervention at day 45 and was considered a
      failure. The pre-massage postoperative IOP was significantly lower for the
      treatment group only at day 45 (16.1 vs 26.0 mm Hg, P = .012). Mean post-massage 
      IOP was significantly lower in the treatment group at day 15 (11.28 vs 17.16 mm
      Hg, P = .004), day 30 (11.28 vs 20.83 mm Hg, P = .015), and day 45 (12.16 vs
      21.33 mm Hg, P = .001), and similar at month 3. Mean change in bleb area was 11.4
      mm(2) in the treatment group and -0.4 mm(2) in the control group (P = .036 and P 
      = .361, respectively, Student's paired samples t test). CONCLUSION: Bevacizumab
      was associated with a less aggressive hypertensive period as measured by
      post-massage IOP measurements, postoperative glaucoma medications, and
      cross-sectional bleb area by ultrasound. Further prospective studies are needed
      to better understand the utility of SCB at the time of AVI surgery.
CI  - Copyright 2011, SLACK Incorporated.
FAU - Rojo-Arnao, Maria
AU  - Rojo-Arnao M
AD  - Asociacion Para Evitar la Ceguera en Mexico, Coyoacan, Mexico.
FAU - Albis-Donado, Oscar D
AU  - Albis-Donado OD
FAU - Lliteras-Cardin, Manuel
AU  - Lliteras-Cardin M
FAU - Kahook, Malik Y
AU  - Kahook MY
FAU - Gil-Carrasco, Felix
AU  - Gil-Carrasco F
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Ophthalmic Surg Lasers Imaging
JT  - Ophthalmic surgery, lasers & imaging : the official journal of the International 
      Society for Imaging in the Eye
JID - 101155780
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antibodies, Monoclonal, Humanized)
RN  - 0 (Antihypertensive Agents)
RN  - 2S9ZZM9Q9V (Bevacizumab)
SB  - IM
MH  - Aged
MH  - Antibodies, Monoclonal/*administration & dosage
MH  - Antibodies, Monoclonal, Humanized
MH  - Antihypertensive Agents/administration & dosage
MH  - Bevacizumab
MH  - Conjunctiva
MH  - Female
MH  - Glaucoma/physiopathology/*surgery
MH  - *Glaucoma Drainage Implants/adverse effects
MH  - Humans
MH  - Injections, Intraocular
MH  - Intraocular Pressure
MH  - Male
MH  - Massage
MH  - Middle Aged
MH  - Ocular Hypertension/diagnostic imaging/etiology/physiopathology/prevention &
      control
MH  - Pilot Projects
MH  - Postoperative Care
MH  - Postoperative Period
MH  - Prospective Studies
MH  - Ultrasonography
EDAT- 2011/03/18 06:00
MHDA- 2011/07/28 06:00
CRDT- 2011/03/18 06:00
PHST- 2010/08/05 00:00 [received]
PHST- 2011/01/06 00:00 [accepted]
PHST- 2011/03/18 06:00 [entrez]
PHST- 2011/03/18 06:00 [pubmed]
PHST- 2011/07/28 06:00 [medline]
AID - 10.3928/15428877-20110316-02 [doi]
PST - ppublish
SO  - Ophthalmic Surg Lasers Imaging. 2011 Mar-Apr;42(2):132-7. doi:
      10.3928/15428877-20110316-02.


PMID- 21409974
OWN - NLM
STAT- MEDLINE
DCOM- 20110531
LR  - 20191112
IS  - 0929-0273 (Print)
IS  - 0929-0273 (Linking)
VI  - 18
IP  - 1
DP  - 2011 Jan
TI  - Ethical standards for clinical trials conducted in third countries: the new
      strategy of the European Medicines Agency.
PG  - 65-75
AB  - Clinical trials increasingly occur on a global scale as industry and government
      sponsors in wealthy countries move trials to low- and middle-income countries.
      The globalization of clinical research raises important questions about the
      economical and ethical aspects of clinical research and the translation of trial 
      results to clinical practice: which ethical standards are applied? Are trials
      results accurate and valid, and can they be extrapolated to other settings? This 
      article provides an overview of the strategy approved by the European Medicines
      Agency (EMA) to clarify ethical standards for clinical research conducted outside
      the European Economic Area (EEA) and included in Marketing Authorization
      Applications. Reference to the EMA Reflection paper is made.
FAU - Altavilla, Annagrazia
AU  - Altavilla A
AD  - Espace Ethique Mediterraneen (Bioethics Research Centre E.A. 3783), Universite de
      la Mediterranee, Marseille, France.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Eur J Health Law
JT  - European journal of health law
JID - 9431861
SB  - IM
MH  - Clinical Trials as Topic/*ethics/standards
MH  - *Developing Countries
MH  - Europe
MH  - Government Agencies
MH  - Human Experimentation/ethics
MH  - Humans
EDAT- 2011/03/18 06:00
MHDA- 2011/06/01 06:00
CRDT- 2011/03/18 06:00
PHST- 2011/03/18 06:00 [entrez]
PHST- 2011/03/18 06:00 [pubmed]
PHST- 2011/06/01 06:00 [medline]
AID - 10.1163/157180911x546129 [doi]
PST - ppublish
SO  - Eur J Health Law. 2011 Jan;18(1):65-75. doi: 10.1163/157180911x546129.


PMID- 21409969
OWN - NLM
STAT- MEDLINE
DCOM- 20110531
LR  - 20191112
IS  - 0929-0273 (Print)
IS  - 0929-0273 (Linking)
VI  - 18
IP  - 1
DP  - 2011 Jan
TI  - Age determination of unaccompanied asylum seeking minors in the European Union: a
      health law perspective.
PG  - 11-25
AB  - In the European Union, unaccompanied asylum seekers below 18 years of age are
      entitled to specific treatment. Age assessment practices to verify the
      age-statement by the asylum seeker differ between EU Member States. Medical
      methods in use raise questions about accuracy, reliability and safety. The
      medical, legal and ethical acceptability of invasive methods (notably X-rays) in 
      particular is controversial. Human rights are at stake. The lack of common
      practices results in different levels of protection (discrimination). The absence
      ofstandardisation is an obstacle for the functioning of the Common European
      Asylum System. EU Best Practice Guidelines should remedy the situation; such
      guidelines should reflect the best interest of the child.
FAU - Abbing, Henriette D C Roscam
AU  - Abbing HD
AD  - Professor Emeritus of Health Law, Amsterdam, The Netherlands.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Eur J Health Law
JT  - European journal of health law
JID - 9431861
SB  - IM
MH  - Age Determination by Skeleton
MH  - Bone and Bones/diagnostic imaging
MH  - European Union
MH  - Humans
MH  - *Minors
MH  - Public Policy/*legislation & jurisprudence
MH  - *Refugees
EDAT- 2011/03/18 06:00
MHDA- 2011/06/01 06:00
CRDT- 2011/03/18 06:00
PHST- 2011/03/18 06:00 [entrez]
PHST- 2011/03/18 06:00 [pubmed]
PHST- 2011/06/01 06:00 [medline]
AID - 10.1163/157180911x546101 [doi]
PST - ppublish
SO  - Eur J Health Law. 2011 Jan;18(1):11-25. doi: 10.1163/157180911x546101.


PMID- 21407262
OWN - NLM
STAT- MEDLINE
DCOM- 20111005
LR  - 20211020
IS  - 1476-5438 (Electronic)
IS  - 1018-4813 (Linking)
VI  - 19
IP  - 7
DP  - 2011 Jul
TI  - Not so simple: a quasi-experimental study of how researchers adjudicate genetic
      research results.
PG  - 740-7
LID - 10.1038/ejhg.2011.34 [doi]
AB  - Ethicists contend that researchers are obliged to report genetic research
      findings to individual study participants when they are clinically significant,
      that is, when they are clinically useful or personally meaningful to
      participants. Yet whether such standards are well understood and can be
      consistently applied remains unknown. We conducted an international,
      cross-sectional survey of cystic fibrosis (CF) and autism genetics researchers
      using a quasi-experimental design to explore factors influencing researchers'
      judgments. Eighty percent of researchers agreed, in principle, that clinically
      significant findings should be reported to individual participants. Yet judgments
      about when a specific finding was considered clinically significant or warranted 
      reporting varied by scientific factors (replication, robustness, intentionality, 
      and disease context), capacity of the research team to explain the results, and
      type of research ethics guidance. Further, judgments were influenced by the
      researchers' disease community (autism or CF), their primary role (clinical,
      molecular, statistical) and their beliefs regarding a general reporting
      obligation. In sum, judgments about the clinical significance of genetic research
      results, and about whether they should be reported, are influenced by scientific 
      parameters as well as contextual factors related to the specific research project
      and the individual researcher. These findings call into question the assumption
      that the conditions under which an obligation to disclose arises are uniformly
      understood and actionable. Adjudicating the clinical readiness of provisional
      data may be a responsibility better suited to evaluative experts at arms' length 
      of the provisional data in question, rather than a responsibility imposed upon
      researchers themselves.
FAU - Hayeems, Robin Zoe
AU  - Hayeems RZ
AD  - Department of Health Policy, Management and Evaluation, University of Toronto,
      Toronto, Ontario, Canada. robin.hayeems@utoronto.ca
FAU - Miller, Fiona Alice
AU  - Miller FA
FAU - Li, Li
AU  - Li L
FAU - Bytautas, Jessica Peace
AU  - Bytautas JP
LA  - eng
GR  - 80495/Cancer Research UK/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110316
PL  - England
TA  - Eur J Hum Genet
JT  - European journal of human genetics : EJHG
JID - 9302235
SB  - IM
MH  - Adult
MH  - Child
MH  - Child Development Disorders, Pervasive/genetics
MH  - Cross-Sectional Studies
MH  - Cystic Fibrosis/genetics
MH  - Disclosure/*ethics
MH  - *Ethics, Research
MH  - Female
MH  - Genetic Research/*ethics
MH  - Health Surveys
MH  - Humans
MH  - Judgment
MH  - Male
MH  - Models, Statistical
MH  - Research Personnel/*ethics/psychology
PMC - PMC3137502
EDAT- 2011/03/17 06:00
MHDA- 2011/10/06 06:00
CRDT- 2011/03/17 06:00
PHST- 2011/03/17 06:00 [entrez]
PHST- 2011/03/17 06:00 [pubmed]
PHST- 2011/10/06 06:00 [medline]
AID - ejhg201134 [pii]
AID - 10.1038/ejhg.2011.34 [doi]
PST - ppublish
SO  - Eur J Hum Genet. 2011 Jul;19(7):740-7. doi: 10.1038/ejhg.2011.34. Epub 2011 Mar
      16.


PMID- 21407122
OWN - NLM
STAT- MEDLINE
DCOM- 20151117
LR  - 20140417
IS  - 1539-0683 (Electronic)
IS  - 0361-929X (Linking)
VI  - 36
IP  - 3
DP  - 2011 May-Jun
TI  - Ethical implications of newborn screening, life-limiting conditions, and
      palliative care.
PG  - 188-96; quiz 197-8
LID - 10.1097/NMC.0b013e318210214c [doi]
AB  - While the first few days of an infant's life usually involve incorporation into a
      joyous family, this period can also be fraught with conditions that affect and
      potentially threaten survival. This article explores the ethical components of
      neonatal conditions such as disorders of sex development and metabolic disorders.
      Ethical issues surrounding futility, requests for unwarranted care, palliative
      care, and neonatal hospice are also discussed. Helping parents through the grief 
      process and ensuring that they are provided opportunities to participate in
      important decisions for their neonate are key components of the nursing role.
      Implications for clinical practice are provided in the form of a case study and
      practical suggestions for assisting parents through these difficult situations.
FAU - Sudia-Robinson, Tanya
AU  - Sudia-Robinson T
AD  - Tanya Sudia-Robinson is a Professor at Georgia Baptist College of Nursing of
      Mercer University where she teaches ethics and research courses in the doctoral
      program. She can be reached via e-mail at Robinson_ts@mercer.edu.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - MCN Am J Matern Child Nurs
JT  - MCN. The American journal of maternal child nursing
JID - 7605941
SB  - IM
MH  - Adult
MH  - Child
MH  - Decision Making/*ethics
MH  - Education, Nursing, Continuing
MH  - Female
MH  - Grief
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Intensive Care, Neonatal/*ethics
MH  - Male
MH  - Neonatal Nursing/*ethics
MH  - Neonatal Screening/*ethics
MH  - *Nurse's Role
MH  - Palliative Care/*ethics
EDAT- 2011/03/17 06:00
MHDA- 2015/11/18 06:00
CRDT- 2011/03/17 06:00
PHST- 2011/03/17 06:00 [entrez]
PHST- 2011/03/17 06:00 [pubmed]
PHST- 2015/11/18 06:00 [medline]
AID - 10.1097/NMC.0b013e318210214c [doi]
PST - ppublish
SO  - MCN Am J Matern Child Nurs. 2011 May-Jun;36(3):188-96; quiz 197-8. doi:
      10.1097/NMC.0b013e318210214c.


PMID- 21407121
OWN - NLM
STAT- MEDLINE
DCOM- 20151117
LR  - 20140417
IS  - 1539-0683 (Electronic)
IS  - 0361-929X (Linking)
VI  - 36
IP  - 3
DP  - 2011 May-Jun
TI  - Neonatal ethical issues: viability, advance directives, family centered care.
PG  - 180-5; quiz 186-7
LID - 10.1097/NMC.0b013e3182102162 [doi]
AB  - Ethical issues in perinatal and NICU settings can arise from a variety of
      situations. This article focuses on issues surrounding viability and the
      incorporation of advance directives and family-centered care. Prenatal education 
      about infant viability, probable scenarios, and parental involvement in
      decision-making are addressed. Considerations for advance directives for complex 
      births and critical decisions at the time of birth are also discussed.
      Implications for nurses and suggested dialogue strategies are provided.
FAU - Sudia-Robinson, Tanya
AU  - Sudia-Robinson T
AD  - Tanya Sudia-Robinson is a Professor at Georgia Baptist College of Nursing of
      Mercer University where she teaches ethics and research courses in the doctoral
      program. She can be reached via e-mail at Robinson_ts@mercer.edu.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - MCN Am J Matern Child Nurs
JT  - MCN. The American journal of maternal child nursing
JID - 7605941
SB  - IM
MH  - Adult
MH  - Advance Directives/*ethics
MH  - Decision Making
MH  - Education, Nursing, Continuing
MH  - Family Nursing/*ethics
MH  - Female
MH  - Fetal Viability
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Intensive Care, Neonatal/*ethics
MH  - Male
MH  - Middle Aged
MH  - Neonatal Nursing/*ethics
MH  - Nurse's Role
MH  - Pregnancy
EDAT- 2011/03/17 06:00
MHDA- 2015/11/18 06:00
CRDT- 2011/03/17 06:00
PHST- 2011/03/17 06:00 [entrez]
PHST- 2011/03/17 06:00 [pubmed]
PHST- 2015/11/18 06:00 [medline]
AID - 10.1097/NMC.0b013e3182102162 [doi]
PST - ppublish
SO  - MCN Am J Matern Child Nurs. 2011 May-Jun;36(3):180-5; quiz 186-7. doi:
      10.1097/NMC.0b013e3182102162.


PMID- 21407081
OWN - NLM
STAT- MEDLINE
DCOM- 20110802
LR  - 20220210
IS  - 1530-0366 (Electronic)
IS  - 1098-3600 (Linking)
VI  - 13
IP  - 4
DP  - 2011 Apr
TI  - Informed consent to microsatellite instability and immunohistochemistry screening
      for Lynch syndrome.
PG  - 356-60
LID - 10.1097/GIM.0b013e31820aee09 [doi]
AB  - OBJECTIVE: Routine microsatellite instability and immunohistochemistry screening 
      of colorectal cancers can assist in identifying a significant proportion of
      cancers attributable to Lynch syndrome. This article considers whether it is
      necessary to obtain patient informed consent for microsatellite instability and
      immunohistochemistry screening. RESULTS: Although microsatellite instability
      screening examines genetic features of a tumor, it lacks several important
      characteristics that typically mandate formal informed consent to genetic
      testing. Microsatellite instability screening describes discrete tissue samples
      and does not provide information about the rest of the patient's body or
      germline. In contrast, immunohistochemistry screening is a proteomic test that
      may reveal information about the patient's germline. As such,
      immunohistochemistry screening can be viewed as similar to other forms of genetic
      testing, in which explicit patient consent is regarded as an ethical
      prerequisite. CONCLUSION: There is no ethical requirement to obtain explicit
      informed consent for microsatellite instability screening of colorectal tumor
      samples for Lynch syndrome. There is support for obtaining patient consent to
      immunohistochemistry testing, given its similarities with other genetic analyses 
      for which informed consent is typically deemed necessary. Regardless of which
      screening test is used, it is important to prepare patients and their families
      for the possibility of a positive screening test.
FAU - Chubak, Barbara
AU  - Chubak B
AD  - Department of Bioethics, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH
      44195, USA.
FAU - Heald, Brandie
AU  - Heald B
FAU - Sharp, Richard R
AU  - Sharp RR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Genet Med
JT  - Genetics in medicine : official journal of the American College of Medical
      Genetics
JID - 9815831
SB  - IM
CIN - Genet Med. 2011 Sep;13(9):848-9. PMID: 21885923
MH  - Colorectal Neoplasms/genetics
MH  - Colorectal Neoplasms, Hereditary Nonpolyposis/*diagnosis/*genetics/pathology
MH  - Genetic Testing/*ethics
MH  - Humans
MH  - Immunohistochemistry
MH  - *Informed Consent
MH  - *Microsatellite Instability
MH  - Proteomics
EDAT- 2011/03/17 06:00
MHDA- 2011/08/04 06:00
CRDT- 2011/03/17 06:00
PHST- 2011/03/17 06:00 [entrez]
PHST- 2011/03/17 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
AID - 10.1097/GIM.0b013e31820aee09 [doi]
AID - S1098-3600(21)00126-X [pii]
PST - ppublish
SO  - Genet Med. 2011 Apr;13(4):356-60. doi: 10.1097/GIM.0b013e31820aee09.


PMID- 21407035
OWN - NLM
STAT- MEDLINE
DCOM- 20110516
LR  - 20110316
IS  - 1537-1948 (Electronic)
IS  - 0025-7079 (Linking)
VI  - 49
IP  - 4
DP  - 2011 Apr
TI  - Discordant views of experts and laypersons on the adoption of new fertility
      technology.
PG  - 420-3
LID - 10.1097/MLR.0b013e3182028ca3 [doi]
AB  - BACKGROUND: Healthcare costs are increased by the adoption of novel technologies 
      before solid evidence on efficacy and risks. Oocyte cryopreservation for
      preserving fertility raises special ethical challenges. We compared opinions of
      professionals for assisted reproductive technology (ART), bioethicists, medical
      students and the general population toward the questions: do you support access
      to oocyte cryopreservation to preserve fertility for personal reasons and who
      should bear the costs? METHODS: The surveys conducted for this study were carried
      out in Israel included the following: (1) survey of 21 ART unit directors; (2)
      interviews with 23 bioethics experts; (3) survey of 196 medical students from 2
      universities; (4) random digit-dial population-based survey of the public
      (N=600). RESULTS: Nearly 80% of ART and bioethics experts and 56% of students
      thought that oocyte cryopreservation should be allowed even for personal reasons.
      While expressing concerns about social consequences, bioethicists emphasized
      individuals' rights. In contrast, among the public, only 40% supported the use of
      this technology for personal reasons (ranging from 24% among Ultra-orthodox Jews 
      and Arabs, to 51% among seculars or with academic education). Of note, 15% were
      undecided (vs. <2% among students, P<0.001). Most experts suggested private
      financing of the procedure for personal reasons, whereas the public preferred
      national or private insurance coverage. CONCLUSIONS: Nonexperts present a greater
      level of ambivalence than experts toward the use of a novel fertility technology 
      for nonmedical reasons. Experts' preferences and interests may facilitate
      adoption of novel technologies with yet unclear effectiveness and safety,
      potentially contributing to increased healthcare costs.
FAU - Brezis, Mayer
AU  - Brezis M
AD  - Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
      brezis@vms.huji.ac.il
FAU - Malkiel, Avishay
AU  - Malkiel A
FAU - Chinitz, David
AU  - Chinitz D
FAU - Lehmann, Lisa Soleymani
AU  - Lehmann LS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Care
JT  - Medical care
JID - 0230027
SB  - IM
MH  - Adult
MH  - *Attitude
MH  - Bioethics
MH  - Cryopreservation
MH  - Data Collection
MH  - *Diffusion of Innovation
MH  - Female
MH  - *Fertility
MH  - Health Policy
MH  - Humans
MH  - Interviews as Topic
MH  - Israel
MH  - Male
MH  - Middle Aged
MH  - Oocyte Retrieval/economics/*ethics
MH  - *Public Opinion
MH  - *Reproductive Techniques, Assisted
EDAT- 2011/03/17 06:00
MHDA- 2011/05/17 06:00
CRDT- 2011/03/17 06:00
PHST- 2011/03/17 06:00 [entrez]
PHST- 2011/03/17 06:00 [pubmed]
PHST- 2011/05/17 06:00 [medline]
AID - 10.1097/MLR.0b013e3182028ca3 [doi]
AID - 00005650-201104000-00015 [pii]
PST - ppublish
SO  - Med Care. 2011 Apr;49(4):420-3. doi: 10.1097/MLR.0b013e3182028ca3.


PMID- 21406651
OWN - NLM
STAT- MEDLINE
DCOM- 20110317
LR  - 20220408
IS  - 1538-3598 (Electronic)
IS  - 0098-7484 (Linking)
VI  - 305
IP  - 11
DP  - 2011 Mar 16
TI  - Informed consent in clinical care: practical considerations in the effort to
      achieve ethical goals.
PG  - 1130-1
LID - 10.1001/jama.2011.333 [doi]
FAU - Schenker, Yael
AU  - Schenker Y
AD  - Division of General Internal Medicine, Section of Palliative Care and Medical
      Ethics, University of Pittsburgh, 230 McKee Pl, Ste 600, Pittsburgh, PA 15213,
      USA. schenkery@upmc.edu
FAU - Meisel, Alan
AU  - Meisel A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - JAMA
JT  - JAMA
JID - 7501160
SB  - IM
MH  - Communication
MH  - *Decision Making
MH  - *Ethics, Medical
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Liability, Legal
MH  - Physician's Role
MH  - Time Factors
MH  - *User-Computer Interface
EDAT- 2011/03/17 06:00
MHDA- 2011/03/18 06:00
CRDT- 2011/03/17 06:00
PHST- 2011/03/17 06:00 [entrez]
PHST- 2011/03/17 06:00 [pubmed]
PHST- 2011/03/18 06:00 [medline]
AID - 305/11/1130 [pii]
AID - 10.1001/jama.2011.333 [doi]
PST - ppublish
SO  - JAMA. 2011 Mar 16;305(11):1130-1. doi: 10.1001/jama.2011.333.


PMID- 21406628
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20140730
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 259
IP  - 2
DP  - 2011 May
TI  - Effect of resting-state functional MR imaging duration on stability of graph
      theory metrics of brain network connectivity.
PG  - 516-24
LID - 10.1148/radiol.11101708 [doi]
AB  - PURPOSE: To investigate the effect of resting-state (RS) functional magnetic
      resonance (MR) imaging blood oxygen level-dependent (BOLD) signal acquisition
      duration on stability of computed graph theory metrics of brain network
      connectivity. MATERIALS AND METHODS: An institutional ethics committee approved
      this study, and informed consent was obtained. BOLD signal (7.5 minutes worth)
      was obtained from 30 subjects and truncated into 30-second time bins that ranged 
      from 1.5 to 7.5 minutes. A binarized adjacency matrix for each subject and
      acquisition duration was generated at network costs between 0.1 and 0.5, where
      network cost is defined as the ratio of the number of edges (connections) in a
      network to the maximum possible number of edges. Measures of correlation
      coefficient stability associated with functional connectivity matrices
      (correlation coefficient standard deviation [SD] and correlation threshold) and
      associated graph theory metrics (small worldness, local efficiency, and global
      efficiency) were computed for each subject at each BOLD signal acquisition
      duration. Computations were implemented with a 15-node 30-core computer cluster
      to enable analysis of the approximately 2000 resulting brain networks. Analysis
      of variance and posthoc analyses were conducted to identify differences between
      time bins for each measure. RESULTS: Small worldness, local efficiency, and
      global efficiency stabilized after 2 minutes of BOLD signal acquisition, whereas 
      correlation coefficient data from functional connectivity matrices (correlation
      coefficient SD and cost-associated threshold) stabilized after 5 minutes of BOLD 
      signal acquisition. CONCLUSION: Graph theory metrics of brain network
      connectivity (small worldness, local efficiency, and global efficiency) may be
      accurately computed from as little as 1.5-2.0 minutes of RS functional MR imaging
      BOLD signal. As such, implementation of these methods in the context of
      time-constrained clinical imaging protocols may be feasible and cost-effective.
      SUPPLEMENTAL MATERIAL:
      http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.11101708/-/DC1.
CI  - RSNA, 2011
FAU - Whitlow, Christopher T
AU  - Whitlow CT
AD  - Advanced NeuroScience Imaging Research Laboratory, Division of Radiologic
      Sciences, Department of Radiology, Wake Forest University School of Medicine,
      Medical Center Blvd, Winston-Salem, NC 27157-1088, USA. cwhitlow@wfubmc.edu
FAU - Casanova, Ramon
AU  - Casanova R
FAU - Maldjian, Joseph A
AU  - Maldjian JA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110315
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
CIN - Radiology. 2011 May;259(2):317-20. PMID: 21502388
MH  - Adolescent
MH  - Adult
MH  - Analysis of Variance
MH  - Brain Diseases/*diagnosis
MH  - Brain Mapping/*methods
MH  - Female
MH  - Humans
MH  - Image Enhancement/*methods
MH  - Image Interpretation, Computer-Assisted
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - *Models, Neurological
MH  - Nerve Net/*anatomy & histology
MH  - Reference Values
EDAT- 2011/03/17 06:00
MHDA- 2011/07/27 06:00
CRDT- 2011/03/17 06:00
PHST- 2011/03/17 06:00 [entrez]
PHST- 2011/03/17 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
AID - radiol.11101708 [pii]
AID - 10.1148/radiol.11101708 [doi]
PST - ppublish
SO  - Radiology. 2011 May;259(2):516-24. doi: 10.1148/radiol.11101708. Epub 2011 Mar
      15.


PMID- 21406625
OWN - NLM
STAT- MEDLINE
DCOM- 20110902
LR  - 20191210
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 260
IP  - 1
DP  - 2011 Jul
TI  - Feasibility of a pneumatically actuated MR-compatible robot for transrectal
      prostate biopsy guidance.
PG  - 241-7
LID - 10.1148/radiol.11101106 [doi]
AB  - PURPOSE: To assess the feasibility of using a remote-controlled, pneumatically
      actuated magnetic resonance (MR)-compatible robotic device to aid transrectal
      biopsy of the prostate performed with real-time 3-T MR imaging guidance.
      MATERIALS AND METHODS: This prospective study was approved by the ethics review
      board, and written informed consent was obtained from all patients. Twelve
      consecutive men who were clinically suspected of having prostate cancer and had a
      history of at least one transrectal ultrasonography (US)-guided prostate biopsy
      with negative results underwent diagnostic multiparametric MR imaging of the
      prostate. Two radiologists in consensus identified cancer-suspicious regions
      (CSRs) in 10 patients. These regions were subsequently targeted with the robot
      for MR imaging-guided prostate biopsy. To direct the needle guide toward the
      CSRs, the MR-compatible robotic device was remote controlled at the MR console by
      means of a controller and a graphical user interface for real-time MR imaging
      guidance of the needle guide. The ability to reach the CSRs with the robot for
      biopsy was analyzed. RESULTS: A total of 17 CSRs were detected in 10 patients at 
      the diagnostic MR examinations. These regions were targeted for MR imaging-guided
      robot-assisted prostate biopsy. Thirteen (76%) of the 17 CSRs could be reached
      with the robot for biopsy. Biopsy of the remaining four CSRs was performed
      without use of the robot. CONCLUSION: It is feasible to perform transrectal
      prostate biopsy with real-time 3-T MR imaging guidance with the aid of a
      remote-controlled, pneumatically actuated MR-compatible robotic device.
FAU - Yakar, Derya
AU  - Yakar D
AD  - Department of Radiology, Radboud University Nijmegen Medical Centre, Geert
      Grooteplein 10, 6500 HB Nijmegen, The Netherlands. D.Yakar@rad.umcn.nl
FAU - Schouten, Martijn G
AU  - Schouten MG
FAU - Bosboom, Dennis G H
AU  - Bosboom DG
FAU - Barentsz, Jelle O
AU  - Barentsz JO
FAU - Scheenen, Tom W J
AU  - Scheenen TW
FAU - Futterer, Jurgen J
AU  - Futterer JJ
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20110315
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Aged
MH  - Biopsy, Needle/*instrumentation
MH  - Equipment Design
MH  - Equipment Failure Analysis
MH  - Feasibility Studies
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Prostatic Neoplasms/*pathology
MH  - Rectum
MH  - Robotics/*instrumentation
MH  - Sensitivity and Specificity
MH  - Surgery, Computer-Assisted/*instrumentation
MH  - Telemedicine/*instrumentation
EDAT- 2011/03/17 06:00
MHDA- 2011/09/03 06:00
CRDT- 2011/03/17 06:00
PHST- 2011/03/17 06:00 [entrez]
PHST- 2011/03/17 06:00 [pubmed]
PHST- 2011/09/03 06:00 [medline]
AID - radiol.11101106 [pii]
AID - 10.1148/radiol.11101106 [doi]
PST - ppublish
SO  - Radiology. 2011 Jul;260(1):241-7. doi: 10.1148/radiol.11101106. Epub 2011 Mar 15.


PMID- 21406340
OWN - NLM
STAT- MEDLINE
DCOM- 20110629
LR  - 20131121
IS  - 1846-9558 (Electronic)
IS  - 1330-0075 (Linking)
VI  - 61
IP  - 1
DP  - 2011 Mar
TI  - International pharmaceutical social risk regulation: An ethical perspective.
PG  - 15-23
LID - 10.2478/v10007-011-0010-x [doi]
AB  - Pharmaceutical production and distribution constitute big business. For the
      companies the rewards can be substantial. Rates of return on drug company
      investments tend to be higher than many other manufacturing enterprises. But
      reward is only one side of the story. There is also the issue of social risk, the
      focus of this article. Social risk for pharmaceutical production is especially
      pronounced. An ineffective or, worse, dangerous drug, can have dire consequences 
      for the population at large. For this reason, there is elaborate government
      regulation and oversight of drug safety and risk. These systems, especially in
      the US and Europe, will be the main focus of this paper. The two systems will be 
      described, and then compared and contrasted in terms of their framing of social
      risk and actions governments take to limit it. Systems elsewhere, especially in
      the developing world, are increasing in relative importance and these will be
      briefly discussed as well. Ethical issues that have arisen in these various
      systems will be surfaced and analysed. The paper will close with some conclusions
      and suggestions for further research.
FAU - Gordon, Cameron
AU  - Gordon C
AD  - Faculty of Business and Government, University of Canberra, Bruce, ACT 2601
      Australia. Cameron.gordon@canberra.edu.au
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Poland
TA  - Acta Pharm
JT  - Acta pharmaceutica (Zagreb, Croatia)
JID - 9303678
SB  - IM
MH  - Drug Industry/economics/ethics/*legislation & jurisprudence
MH  - *Drug-Related Side Effects and Adverse Reactions
MH  - Europe
MH  - Humans
MH  - *Legislation, Drug
MH  - Risk
MH  - Risk Assessment/legislation & jurisprudence
MH  - Social Responsibility
MH  - United States
EDAT- 2011/03/17 06:00
MHDA- 2011/06/30 06:00
CRDT- 2011/03/17 06:00
PHST- 2011/03/17 06:00 [entrez]
PHST- 2011/03/17 06:00 [pubmed]
PHST- 2011/06/30 06:00 [medline]
AID - L15M37142639N277 [pii]
AID - 10.2478/v10007-011-0010-x [doi]
PST - ppublish
SO  - Acta Pharm. 2011 Mar;61(1):15-23. doi: 10.2478/v10007-011-0010-x.


PMID- 21406113
OWN - NLM
STAT- MEDLINE
DCOM- 20110614
LR  - 20211020
IS  - 1475-2875 (Electronic)
IS  - 1475-2875 (Linking)
VI  - 10
DP  - 2011 Mar 15
TI  - Randomized controlled trials of malaria intervention trials in Africa, 1948 to
      2007: a descriptive analysis.
PG  - 61
LID - 10.1186/1475-2875-10-61 [doi]
AB  - BACKGROUND: Nine out of ten deaths from malaria occur in sub-Saharan Africa.
      Various control measures have achieved some progress in the control of the
      disease, but malaria is still a major public health problem in Africa. Randomized
      controlled trials (RCTs) are universally considered the best study type to
      rigorously assess whether an intervention is effective. The study reported here
      provides a descriptive analysis of RCTs reporting interventions for the
      prevention and treatment of malaria conducted in Africa, with the aim of
      providing detailed information on their main clinical and methodological
      characteristics, that could be used by researchers and policy makers to help plan
      future research. METHODS: Systematic searches for malaria RCTs were conducted
      using electronic databases (Medline, Embase, the Cochrane Library), and an
      African geographic search filter to identify RCTs conducted in Africa was
      applied. Results were exported to the statistical package STATA 8 to obtain a
      random sample from the overall data set. Final analysis of trial characteristics 
      was done in a double blinded fashion by two authors using a standardized data
      extraction form. RESULTS: A random sample of 92 confirmed RCTs (from a total of
      943 reports obtained between 1948 and 2007) was prepared. Most trials
      investigated drug treatment in children with uncomplicated malaria. Few trials
      reported on treatment of severe malaria or on interventions in pregnant women.
      Most trials were of medium size (100-500 participants), individually randomized
      and based in a single centre. Reporting of trial quality was variable. Although
      three-quarter of trials provided information on participants' informed consent
      and ethics approval, more details are needed. CONCLUSIONS: The majority of
      malaria RCT conducted in Africa report on drug treatment and prevention in
      children; there is need for more research done in pregnant women. Sources of
      funding, informed consent and trial quality were often poorly reported. Overall, 
      clearer reporting of trials is needed.
FAU - Lutje, Vittoria
AU  - Lutje V
AD  - International Health Research Group, Liverpool School of Tropical Medicine,
      Liverpool, UK. vlutje@liv.ac.uk
FAU - Gerritsen, Annette
AU  - Gerritsen A
FAU - Siegfried, Nandi
AU  - Siegfried N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110315
PL  - England
TA  - Malar J
JT  - Malaria journal
JID - 101139802
SB  - IM
MH  - Adult
MH  - Africa/epidemiology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Malaria/*drug therapy/*epidemiology/prevention & control
MH  - Male
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/drug therapy/prevention & control
MH  - *Randomized Controlled Trials as Topic
PMC - PMC3064642
EDAT- 2011/03/17 06:00
MHDA- 2011/06/15 06:00
CRDT- 2011/03/17 06:00
PHST- 2010/10/04 00:00 [received]
PHST- 2011/03/15 00:00 [accepted]
PHST- 2011/03/17 06:00 [entrez]
PHST- 2011/03/17 06:00 [pubmed]
PHST- 2011/06/15 06:00 [medline]
AID - 1475-2875-10-61 [pii]
AID - 10.1186/1475-2875-10-61 [doi]
PST - epublish
SO  - Malar J. 2011 Mar 15;10:61. doi: 10.1186/1475-2875-10-61.


PMID- 21404784
OWN - NLM
STAT- MEDLINE
DCOM- 20110503
LR  - 20211020
IS  - 1470-2118 (Print)
IS  - 1470-2118 (Linking)
VI  - 11
IP  - 1
DP  - 2011 Feb
TI  - Paper use in research ethics applications and study conduct.
PG  - 44-7
AB  - Application for Research Ethics Committee (REC) approval and the conduct of
      medical research is paper intensive. This retrospective study examined all
      applications to a single REC in the south of England over one year. It estimated 
      the mass of paper used, comparing the proportional paper consumption of different
      trial types and during different stages of the research process, quantifying the 
      consumption in terms of carbon dioxide emissions. In 2009, 68 trials were
      submitted to the REC. Total paper consumption for the REC process and study
      conduct was 176,150 sheets of A4 paper (879 kg), equivalent to an estimated 11.5 
      million sheets (88 tonnes, 2100 trees) a year for the U.K.; the REC process
      accounted for 26.4%. REC applications and the conduct of approved trials generate
      considerable environmental impact through paper consumption contributing to the
      NHS's carbon footprint. Paper use might be reduced through the implementation of 
      digital technologies and revised research methods, namely changing attitudes in
      both researchers and ethics committees.
FAU - Chakladar, Abhijoy
AU  - Chakladar A
AD  - Department of Anaesthesia, Brighton and Sussex University Hospitals NHS Trust.
      abhijoy.chakladar@gmail.com
FAU - Eckstein, Sue
AU  - Eckstein S
FAU - White, Stuart M
AU  - White SM
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Med (Lond)
JT  - Clinical medicine (London, England)
JID - 101092853
SB  - IM
MH  - Biomedical Research/ethics/*instrumentation
MH  - Ethics Committees/*organization & administration
MH  - *Ethics, Research
MH  - Humans
MH  - *Paper
MH  - Retrospective Studies
MH  - Surveys and Questionnaires
MH  - United Kingdom
PMC - PMC5873802
EDAT- 2011/03/17 06:00
MHDA- 2011/05/04 06:00
CRDT- 2011/03/17 06:00
PHST- 2011/03/17 06:00 [entrez]
PHST- 2011/03/17 06:00 [pubmed]
PHST- 2011/05/04 06:00 [medline]
AID - 10.7861/clinmedicine.11-1-44 [doi]
PST - ppublish
SO  - Clin Med (Lond). 2011 Feb;11(1):44-7. doi: 10.7861/clinmedicine.11-1-44.


PMID- 21404715
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20181201
IS  - 1009-3591 (Print)
IS  - 1009-3591 (Linking)
VI  - 17
IP  - 2
DP  - 2011 Feb
TI  - [Progress in researches on 46, XY disorders of sexual development].
PG  - 156-9
AB  - 46, XY disorders of sexual development (46, XY DSD) are a group of complicated
      clinical conditions, which involve medical care, society, ethics and many other
      aspects. As chronic diseases, they necessitate long-term or even lifelong
      physical and mental follow-up and treatment. Early diagnosis and reasonable
      treatment could not only achieve appropriate development of the secondary sexual 
      characteristics, but also effectively prevent gonadal malignancy. In recent
      years, environment pollution and other factors are contributing to the increasing
      incidence of 46, XY DSD all over the world. A deeper clinical insight into these 
      disorders helps their earlier diagnosis and maximum improvement of prognosis. The
      etiology, new classification and treatment of 46, XY DSD are reviewed in this
      article.
FAU - Duan, Shou-xing
AU  - Duan SX
AD  - Department of Pediatric Surgery, The Second Hospital of Shantou University
      Medical College, Shantou, Guangdong 515041, China.
FAU - Li, Jian-hong
AU  - Li JH
FAU - Jiang, Xue-wu
AU  - Jiang XW
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - China
TA  - Zhonghua Nan Ke Xue
JT  - Zhonghua nan ke xue = National journal of andrology
JID - 101093592
SB  - IM
MH  - *Disorder of Sex Development, 46,XY/classification/diagnosis/therapy
MH  - Humans
MH  - Male
EDAT- 2011/03/17 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/03/17 06:00
PHST- 2011/03/17 06:00 [entrez]
PHST- 2011/03/17 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
PST - ppublish
SO  - Zhonghua Nan Ke Xue. 2011 Feb;17(2):156-9.


PMID- 21404506
OWN - NLM
STAT- MEDLINE
DCOM- 20110517
LR  - 20110315
IS  - 0253-0465 (Print)
IS  - 0253-0465 (Linking)
VI  - 104
IP  - 2
DP  - 2011
TI  - [Ethical considerations. Boundary limits in the home].
PG  - 44-7
FAU - Germanier, Francois
AU  - Germanier F
AD  - Fondation des services d'aide et de soins a domicile, Geneve.
      francois.germanier@fsasd.ch
FAU - Loew, Francois
AU  - Loew F
FAU - Ummel, Marinette
AU  - Ummel M
FAU - Zumwald, Catherine
AU  - Zumwald C
LA  - fre
PT  - Case Reports
PT  - Journal Article
TT  - Considerations ethiques. Les limites du maintien a domicile.
PL  - Switzerland
TA  - Krankenpfl Soins Infirm
JT  - Krankenpflege. Soins infirmiers
JID - 8000153
MH  - Aged, 80 and over
MH  - Chronic Disease/*nursing/psychology
MH  - Communication
MH  - *Ethics, Nursing
MH  - Female
MH  - Home Care Services/*ethics
MH  - Humans
MH  - Interdisciplinary Communication
MH  - Male
MH  - Nurse-Patient Relations/ethics
MH  - Nursing Assessment
MH  - Patient Care Team
MH  - Personal Autonomy
MH  - Population Dynamics
MH  - Quality of Life/psychology
MH  - Switzerland
EDAT- 2011/03/17 06:00
MHDA- 2011/05/18 06:00
CRDT- 2011/03/17 06:00
PHST- 2011/03/17 06:00 [entrez]
PHST- 2011/03/17 06:00 [pubmed]
PHST- 2011/05/18 06:00 [medline]
PST - ppublish
SO  - Krankenpfl Soins Infirm. 2011;104(2):44-7.


PMID- 21403972
OWN - NLM
STAT- MEDLINE
DCOM- 20110913
LR  - 20220331
IS  - 1757-9708 (Electronic)
IS  - 1757-9694 (Linking)
VI  - 3
IP  - 5
DP  - 2011 May
TI  - The mass-action law based algorithms for quantitative econo-green bio-research.
PG  - 548-59
LID - 10.1039/c0ib00130a [doi]
AB  - The relationship between dose and effect is not random, but rather governed by
      the unified theory based on the median-effect equation (MEE) of the mass-action
      law. Rearrangement of MEE yields the mathematical form of the Michaelis-Menten,
      Hill, Henderson-Hasselbalch and Scatchard equations of biochemistry and
      biophysics, and the median-effect plot allows linearization of all dose-effect
      curves regardless of potency and shape. The "median" is the universal common-link
      and reference-point for the 1st-order to higher-order dynamics, and from
      single-entities to multiple-entities and thus, it allows the all for one and one 
      for all unity theory to "integrate" simple and complex systems. Its applications 
      include the construction of a dose-effect curve with a theoretical minimum of
      only two data points if they are accurately determined; quantification of
      synergism or antagonism at all dose and effect levels; the low-dose risk
      assessment for carcinogens, toxic substances or radiation; and the determination 
      of competitiveness and exclusivity for receptor binding. Since the MEE algorithm 
      allows the reduced requirement of the number of data points for small size
      experimentation, and yields quantitative bioinformatics, it points to the
      deterministic, efficient, low-cost biomedical research and drug discovery, and
      ethical planning for clinical trials. It is concluded that the contemporary
      biomedical sciences would greatly benefit from the mass-action law based "Green
      Revolution".
FAU - Chou, Ting-Chao
AU  - Chou TC
AD  - Preclinical Pharmacology Core Laboratory, Molecular Pharmacology & Chemistry
      Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY
      10065, USA. chout@mskcc.org
LA  - eng
PT  - Journal Article
DEP - 20110314
PL  - England
TA  - Integr Biol (Camb)
JT  - Integrative biology : quantitative biosciences from nano to macro
JID - 101478378
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - *Algorithms
MH  - Cell Physiological Phenomena/*drug effects
MH  - Computer Simulation
MH  - *Dose-Response Relationship, Drug
MH  - Green Chemistry Technology/*trends
MH  - *Models, Biological
MH  - Pharmaceutical Preparations/*administration & dosage
EDAT- 2011/03/16 06:00
MHDA- 2011/09/14 06:00
CRDT- 2011/03/16 06:00
PHST- 2011/03/16 06:00 [entrez]
PHST- 2011/03/16 06:00 [pubmed]
PHST- 2011/09/14 06:00 [medline]
AID - 10.1039/c0ib00130a [doi]
PST - ppublish
SO  - Integr Biol (Camb). 2011 May;3(5):548-59. doi: 10.1039/c0ib00130a. Epub 2011 Mar 
      14.


PMID- 21403931
OWN - NLM
STAT- MEDLINE
DCOM- 20110407
LR  - 20210227
IS  - 1461-5185 (Print)
IS  - 1461-5185 (Linking)
VI  - 13
IP  - 1
DP  - 2011 Feb
TI  - Ethics in publishing.
PG  - 3
LID - 10.3290/j.jad.a21214 [doi]
FAU - Roulet, Jean-Francois
AU  - Roulet JF
LA  - eng
PT  - Editorial
PL  - Germany
TA  - J Adhes Dent
JT  - The journal of adhesive dentistry
JID - 100888552
MH  - *Authorship
MH  - *Editorial Policies
MH  - Humans
MH  - Periodicals as Topic/*ethics
MH  - Publishing/*ethics
EDAT- 2011/03/16 06:00
MHDA- 2011/04/08 06:00
CRDT- 2011/03/16 06:00
PHST- 2011/03/16 06:00 [entrez]
PHST- 2011/03/16 06:00 [pubmed]
PHST- 2011/04/08 06:00 [medline]
AID - 842876 [pii]
AID - 10.3290/j.jad.a21214 [doi]
PST - ppublish
SO  - J Adhes Dent. 2011 Feb;13(1):3. doi: 10.3290/j.jad.a21214.


PMID- 21403486
OWN - NLM
STAT- MEDLINE
DCOM- 20110712
LR  - 20110315
IS  - 1550-5103 (Electronic)
IS  - 0363-9568 (Linking)
VI  - 35
IP  - 2
DP  - 2011 Apr-Jun
TI  - Ethical perspectives of sustaining residents' autonomy: a cultural transformation
      best practice.
PG  - 126-33
LID - 10.1097/NAQ.0b013e31820fbd80 [doi]
AB  - Baby boomers are demanding changes in care delivery models that reflect patient
      autonomy, individuality, and dignity. To meet this challenge, the Veterans
      Administration has adopted a cultural transformation model of patient-centered
      care. Veterans Administration nursing homes are now community living centers; the
      staff's mission is to deliver patient-centered care in a homelike environment.
      How the challenge was met and how the ethics committee helps to sustain the
      changes, are discussed in this article.
FAU - Dunbar, Berthenya
AU  - Dunbar B
AD  - Haley's Cove Community Living Center, James A Haley Veterans Hospital, Tampa,
      Florida 33612, USA. berthenya.dunbar@va.gov
FAU - Sink, Paul
AU  - Sink P
FAU - Alsobrook, Devon
AU  - Alsobrook D
FAU - Bailey, Bonita
AU  - Bailey B
FAU - Lonczak, Terry
AU  - Lonczak T
FAU - Starnes, Rhonda
AU  - Starnes R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Nurs Adm Q
JT  - Nursing administration quarterly
JID - 7703976
MH  - *Benchmarking
MH  - Efficiency, Organizational
MH  - Ethics Committees
MH  - *Ethics, Nursing
MH  - Humans
MH  - Nursing Homes/ethics
MH  - *Organizational Culture
MH  - Patient-Centered Care/*ethics
MH  - *Personal Autonomy
MH  - Personhood
MH  - Quality of Life/*psychology
MH  - Social Support
MH  - United States
MH  - United States Department of Veterans Affairs
EDAT- 2011/03/16 06:00
MHDA- 2011/07/13 06:00
CRDT- 2011/03/16 06:00
PHST- 2011/03/16 06:00 [entrez]
PHST- 2011/03/16 06:00 [pubmed]
PHST- 2011/07/13 06:00 [medline]
AID - 10.1097/NAQ.0b013e31820fbd80 [doi]
AID - 00006216-201104000-00006 [pii]
PST - ppublish
SO  - Nurs Adm Q. 2011 Apr-Jun;35(2):126-33. doi: 10.1097/NAQ.0b013e31820fbd80.


PMID- 21403179
OWN - NLM
STAT- MEDLINE
DCOM- 20110719
LR  - 20110315
IS  - 1555-824X (Electronic)
IS  - 1062-8606 (Linking)
VI  - 26
IP  - 2
DP  - 2011 Mar-Apr
TI  - Quality, safety, and institutional review boards: navigating ethics and oversight
      in applied health systems research.
PG  - 157-9
LID - 10.1177/1062860610377109 [doi]
FAU - Kass, Nancy E
AU  - Kass NE
AD  - Johns Hopkins Berman Institute of Bioethics, Johns Hopkins Bloomberg School of
      Public Health, 624 N Broadway, Baltimore, MD 21205, USA. nkass@jhsph.edu
FAU - Pronovost, Peter J
AU  - Pronovost PJ
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Am J Med Qual
JT  - American journal of medical quality : the official journal of the American
      College of Medical Quality
JID - 9300756
SB  - IM
MH  - Decision Making, Organizational
MH  - *Ethics Committees, Research
MH  - Health Services Research/*ethics/organization & administration
MH  - Hospitals
MH  - Humans
MH  - Informed Consent/ethics
MH  - *Quality Improvement/ethics
MH  - *Safety Management/ethics
MH  - United States
EDAT- 2011/03/16 06:00
MHDA- 2011/07/20 06:00
CRDT- 2011/03/16 06:00
PHST- 2011/03/16 06:00 [entrez]
PHST- 2011/03/16 06:00 [pubmed]
PHST- 2011/07/20 06:00 [medline]
AID - 26/2/157 [pii]
AID - 10.1177/1062860610377109 [doi]
PST - ppublish
SO  - Am J Med Qual. 2011 Mar-Apr;26(2):157-9. doi: 10.1177/1062860610377109.


PMID- 21403046
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20211020
IS  - 1538-3679 (Electronic)
IS  - 0003-9926 (Linking)
VI  - 171
IP  - 5
DP  - 2011 Mar 14
TI  - The impact of medical school oaths and other professional codes of ethics:
      results of a national physician survey.
PG  - 469-71
LID - 10.1001/archinternmed.2011.47 [doi]
FAU - Antiel, Ryan M
AU  - Antiel RM
FAU - Curlin, Farr A
AU  - Curlin FA
FAU - Hook, C Christopher
AU  - Hook CC
FAU - Tilburt, Jon C
AU  - Tilburt JC
LA  - eng
GR  - KL2 RR024151/RR/NCRR NIH HHS/United States
GR  - 1 KL2 RR024151/RR/NCRR NIH HHS/United States
PT  - Letter
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Arch Intern Med
JT  - Archives of internal medicine
JID - 0372440
SB  - IM
CIN - Arch Ophthalmol. 2011 Sep;129(9):1221-2. PMID: 21911672
MH  - Adult
MH  - Female
MH  - Health Care Surveys/ethics
MH  - *Hippocratic Oath
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Physicians/*ethics
MH  - Schools, Medical/*ethics
MH  - United States
PMC - PMC3951008
MID - NIHMS552527
EDAT- 2011/03/16 06:00
MHDA- 2011/06/03 06:00
CRDT- 2011/03/16 06:00
PHST- 2011/03/16 06:00 [entrez]
PHST- 2011/03/16 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
AID - 171/5/469 [pii]
AID - 10.1001/archinternmed.2011.47 [doi]
PST - ppublish
SO  - Arch Intern Med. 2011 Mar 14;171(5):469-71. doi: 10.1001/archinternmed.2011.47.


PMID- 21402635
OWN - NLM
STAT- MEDLINE
DCOM- 20110531
LR  - 20120111
IS  - 1098-4275 (Electronic)
IS  - 0031-4005 (Linking)
VI  - 127
IP  - 4
DP  - 2011 Apr
TI  - An infant with trisomy 18 and a ventricular septal defect.
PG  - 754-9
LID - 10.1542/peds.2010-1971 [doi]
AB  - Decisions for critically ill infants with trisomy 18 raise thorny issues about
      values, futility, the burdens of treatment, cost-effectiveness, and justice. We
      presented the case of an infant with trisomy 18 to 2 neonatologists with
      experience in clinical ethics, Annie Janvier and Felix Okah, and to a parent,
      Barbara Farlow. They do not agree about the right thing to do.
FAU - Janvier, Annie
AU  - Janvier A
AD  - Department of Pediatrics, University of Montreal, Montreal, Quebec, Canada.
FAU - Okah, Felix
AU  - Okah F
FAU - Farlow, Barbara
AU  - Farlow B
FAU - Lantos, John D
AU  - Lantos JD
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20110314
PL  - United States
TA  - Pediatrics
JT  - Pediatrics
JID - 0376422
RN  - Chromosome 18, trisomy 18p
SB  - IM
CIN - Pediatrics. 2011 Dec;128(6):e1642-3; author reply e1643-4. PMID: 22135415
MH  - Abortion, Eugenic/ethics
MH  - Child
MH  - Child, Preschool
MH  - Chromosomes, Human, Pair 18/genetics
MH  - *Ethics, Medical
MH  - Female
MH  - Genetic Counseling/*ethics
MH  - Heart Septal Defects, Ventricular/diagnosis/*genetics/mortality/surgery
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Life Support Care/ethics
MH  - Male
MH  - Palliative Care/*ethics
MH  - Parental Consent/ethics
MH  - Pregnancy
MH  - Prenatal Diagnosis/*ethics
MH  - Professional-Family Relations
MH  - Prognosis
MH  - Survival Rate
MH  - Trisomy/diagnosis/genetics
MH  - Withholding Treatment/ethics
EDAT- 2011/03/16 06:00
MHDA- 2011/06/01 06:00
CRDT- 2011/03/16 06:00
PHST- 2011/03/16 06:00 [entrez]
PHST- 2011/03/16 06:00 [pubmed]
PHST- 2011/06/01 06:00 [medline]
AID - peds.2010-1971 [pii]
AID - 10.1542/peds.2010-1971 [doi]
PST - ppublish
SO  - Pediatrics. 2011 Apr;127(4):754-9. doi: 10.1542/peds.2010-1971. Epub 2011 Mar 14.


PMID- 21402004
OWN - NLM
STAT- MEDLINE
DCOM- 20110525
LR  - 20211020
IS  - 1478-5242 (Electronic)
IS  - 0960-1643 (Linking)
VI  - 61
IP  - 582
DP  - 2011 Jan
TI  - Our first experience of an ethics committee: entering the Dragon's Den.
PG  - 70
LID - 10.3399/bjgp11X549117 [doi]
FAU - Sandhu, Jagdeep
AU  - Sandhu J
FAU - Khan, Nyla
AU  - Khan N
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Gen Pract
JT  - The British journal of general practice : the journal of the Royal College of
      General Practitioners
JID - 9005323
SB  - IM
MH  - *Ethics Committees, Research
MH  - *Ethics, Medical
MH  - Humans
MH  - *Research
PMC - PMC3020061
EDAT- 2011/03/16 06:00
MHDA- 2011/05/26 06:00
CRDT- 2011/03/16 06:00
PHST- 2011/03/16 06:00 [entrez]
PHST- 2011/03/16 06:00 [pubmed]
PHST- 2011/05/26 06:00 [medline]
AID - 10.3399/bjgp11X549117 [doi]
PST - ppublish
SO  - Br J Gen Pract. 2011 Jan;61(582):70. doi: 10.3399/bjgp11X549117.


PMID- 21401975
OWN - NLM
STAT- MEDLINE
DCOM- 20141117
LR  - 20140321
IS  - 1710-1107 (Electronic)
IS  - 0714-9808 (Linking)
VI  - 30
IP  - 1
DP  - 2011 Mar
TI  - [Palliative care decision making among the elderly and family: a theoretical
      model].
PG  - 127-42
LID - 10.1017/S0714980810000772 [doi]
AB  - The elderly in palliative care are confronted with difficult decisions relating
      to treatments. The philosophy of palliative care, namely, including the patient
      and his/her family right away, leads the doctor to consult with the two parties
      involved when choosing a treatment. As no theoretical model allows us to
      understand how the decision-making process hinges on the trio (a capable elderly 
      person, a family caregiver, and the doctor) in a context of palliative care, we
      propose one which was developed from three strategies of document analysis:
      theoretical synthesis, theoretical analysis, and theoretical derivation.
      According to our model, the decision-making process depends on individual factors
      influencing the decision of the participant, expectations and attitudes as to the
      role, the level of confidence amongst the parties involved, the manner in which
      they communicate with each other, their mutual understanding of the clinical and 
      ethical issues, and, finally, their ability to cooperate.
FAU - Lamontagne, Julie
AU  - Lamontagne J
AD  - Universite de Sherbrooke.
FAU - Beaulieu, Marie
AU  - Beaulieu M
AD  - Universite de Sherbrooke.
FAU - Arcand, Marcel
AU  - Arcand M
AD  - Universite de Sherbrooke.
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Le choix de traitement en triade incluant un patient age apte en soins palliatifs
      : a la recherche d'un modele theorique.
DEP - 20110315
PL  - Canada
TA  - Can J Aging
JT  - Canadian journal on aging = La revue canadienne du vieillissement
JID - 8708560
SB  - IM
MH  - Aged
MH  - Communication
MH  - *Decision Making
MH  - *Family
MH  - Family Relations
MH  - Humans
MH  - *Models, Theoretical
MH  - *Palliative Care
MH  - Physician-Patient Relations
MH  - Professional-Family Relations
EDAT- 2011/03/16 06:00
MHDA- 2014/11/18 06:00
CRDT- 2011/03/16 06:00
PHST- 2011/03/16 06:00 [entrez]
PHST- 2011/03/16 06:00 [pubmed]
PHST- 2014/11/18 06:00 [medline]
AID - S0714980810000772 [pii]
AID - 10.1017/S0714980810000772 [doi]
PST - ppublish
SO  - Can J Aging. 2011 Mar;30(1):127-42. doi: 10.1017/S0714980810000772. Epub 2011 Mar
      15.


PMID- 21401762
OWN - NLM
STAT- MEDLINE
DCOM- 20111013
LR  - 20110614
IS  - 1365-2702 (Electronic)
IS  - 0962-1067 (Linking)
VI  - 20
IP  - 13-14
DP  - 2011 Jul
TI  - Literature review: understanding nursing competence in dementia care.
PG  - 1948-60
LID - 10.1111/j.1365-2702.2010.03511.x [doi]
AB  - AIMS AND OBJECTIVES: The aim of this study was to review dementia nursing
      competencies. The objectives were to explain the relevancy of dementia
      competencies across care settings and levels of practice. BACKGROUND: Dementia is
      strongly associated with increasing age and as the world population ages there is
      an imperative to ensure the healthcare workforce is fully equipped to meet the
      needs of people with dementia and their carers. DESIGN: A literature review study
      addressed the research aim and objectives. METHOD: Literature sources were (i)
      academic databases, (ii) the internet and (iii) snowballing. Search terms were
      'dementia', 'care standards', 'training and education' and 'competency'. RESULTS:
      The sample consisted of 59 reviewed publications. A synthesis of the findings
      generated 10 dementia competencies: (i) Understanding Dementia; (ii) Recognising 
      Dementia; (iii) Effective Communication; (iv) Assisting with Daily Living
      Activities; (v) Promoting a Positive Environment; (vi) Ethical and Person-Centred
      Care; (vii) Therapeutic Work (Interventions); (viii) Responding the needs of
      Family Carers; (ix) Preventative Work and Health Promotion and (x) Special Needs 
      Groups. There were also five levels of practice: (i) Novice; (ii) Beginner; (iii)
      Competent; (iv) Proficient and (v) Expert and no care setting specific
      competencies were generated. CONCLUSION: Government initiatives demonstrate
      commitments to dementia, such as Australia's adoption of dementia as a National
      Health Priority and the UK National Dementia Strategy. Registration boards for
      the nursing workforce in Japan and the UK included dementia competencies in
      generalist frameworks to emphasise the importance of dementia as a healthcare
      issue. This study demonstrated that there is no dementia competency framework
      relevant across care settings or levels of practice. RELEVANCE TO CLINICAL
      PRACTICE: An empirical study will develop a multi-disciplinary dementia
      competency framework relevant across care settings and levels of practice to
      ensure the healthcare workforce can effectively deliver services to people with
      dementia and their carers.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Traynor, Victoria
AU  - Traynor V
AD  - Rehabilitation, Continuing & Aged Care and NSW/ACT Dementia Training Study
      Centre, University of Wollongong, Wollongong, NSW, Australia.
      victoria_traynor@uow.edu.au
FAU - Inoue, Kumiyo
AU  - Inoue K
FAU - Crookes, Patrick
AU  - Crookes P
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110315
PL  - England
TA  - J Clin Nurs
JT  - Journal of clinical nursing
JID - 9207302
MH  - *Clinical Competence
MH  - Dementia/*nursing
MH  - Humans
EDAT- 2011/03/16 06:00
MHDA- 2011/10/14 06:00
CRDT- 2011/03/16 06:00
PHST- 2011/03/16 06:00 [entrez]
PHST- 2011/03/16 06:00 [pubmed]
PHST- 2011/10/14 06:00 [medline]
AID - 10.1111/j.1365-2702.2010.03511.x [doi]
PST - ppublish
SO  - J Clin Nurs. 2011 Jul;20(13-14):1948-60. doi: 10.1111/j.1365-2702.2010.03511.x.
      Epub 2011 Mar 15.


PMID- 21401681
OWN - NLM
STAT- MEDLINE
DCOM- 20110524
LR  - 20110315
IS  - 1365-2923 (Electronic)
IS  - 0308-0110 (Linking)
VI  - 45
IP  - 4
DP  - 2011 Apr
TI  - Towards effective outcomes in teaching, learning and assessment of law in medical
      education.
PG  - 339-46
LID - 10.1111/j.1365-2923.2010.03882.x [doi]
AB  - CONTEXT: Law is slowly emerging as a core subject area in medical education,
      alongside content on the ethical responsibilities of doctors to protect and
      promote patient health and well-being. Curriculum statements have begun to advise
      on core content and methods for organising teaching and assessment. However, no
      comprehensive overview of approaches to the delivery of this law curriculum has
      been undertaken. OBJECTIVES: This paper reports an assessment of the nature and
      strength of the published evidence base for the teaching, learning and assessment
      of law in medical education. It also provides a thematic content overview from
      the best available literature on the teaching of law to medical students and on
      the assessment of their legal knowledge and skills. METHODS: A systematic review 
      of the evidence base was completed. Detailed scrutiny resulted in the inclusion
      of 31 empirical sources and 11 conceptual papers. The quality of the included
      material was assessed. RESULTS: Significant gaps exist in the evidence base.
      Empirical studies of the teaching of law are characterised by insufficient sample
      sizes and a focus on individual study programmes. They rely on measures of
      student satisfaction and on evaluating short-term outcomes rather than assessing 
      whether knowledge is retained and whether learning impacts on patient outcomes.
      Studies reveal a lack of coordination between pre- or non-clinical and clinical
      medico-legal education. Although evidence on the development of students'
      knowledge is available, much learning is distant from the practice in which its
      application would be tested. Law learning in clinical placements appears to be
      opportunistic rather than structured. CONCLUSIONS: The place of law in the
      curriculum remains uncertain and should be more clearly identified. A more robust
      knowledge base is needed to realise the aspirations behind curriculum statements 
      on law and to enable medical students to develop sufficient legal literacy to
      manage challenging practice encounters. Further research is needed into effective
      methods of teaching, learning and assessing legal knowledge and skills during and
      following initial medical education.
CI  - (c) Blackwell Publishing Ltd 2011.
FAU - Preston-Shoot, Michael
AU  - Preston-Shoot M
AD  - Faculty of Health and Social Sciences, University of Bedfordshire, Luton, UK.
      michael.preston-shoot@beds.ac.uk
FAU - McKimm, Judy
AU  - McKimm J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Med Educ
JT  - Medical education
JID - 7605655
SB  - IM
MH  - Clinical Competence
MH  - Clinical Medicine/*education
MH  - *Curriculum
MH  - Education, Medical, Undergraduate/*methods
MH  - Ethics, Medical/*education
MH  - Humans
MH  - *Legislation, Medical
MH  - Teaching/methods
EDAT- 2011/03/16 06:00
MHDA- 2011/05/25 06:00
CRDT- 2011/03/16 06:00
PHST- 2011/03/16 06:00 [entrez]
PHST- 2011/03/16 06:00 [pubmed]
PHST- 2011/05/25 06:00 [medline]
AID - 10.1111/j.1365-2923.2010.03882.x [doi]
PST - ppublish
SO  - Med Educ. 2011 Apr;45(4):339-46. doi: 10.1111/j.1365-2923.2010.03882.x.


PMID- 21401629
OWN - NLM
STAT- MEDLINE
DCOM- 20110506
LR  - 20110315
IS  - 1749-6632 (Electronic)
IS  - 0077-8923 (Linking)
VI  - 1221
DP  - 2011 Mar
TI  - Uterine transplantation: a promising surrogate to surrogacy?
PG  - 47-53
LID - 10.1111/j.1749-6632.2011.05952.x [doi]
AB  - Infertility due to the inability of the uterus to carry a pregnancy ranks among
      the most unresolved issues in reproductive medicine. It affects millions of women
      worldwide who have congenital or acquired uterine affections, often requiring
      hysterectomy, and potentially represents a considerable fraction of the general
      infertile population. Patients suffering from severe uterine infertility are
      currently compelled to go through gestational surrogacy or adoption; both
      approaches, unfortunately, deprive them of the maternal experience of pregnancy
      and birth. Uterine transplantation represents an outstanding, yet complex,
      perspective to alleviating definitive uterine infertility. In the past decades, a
      number of scientific experiments conducted both in animals and women, focusing on
      uterine transplantation, have led to promising results. Collectively, these
      findings undoubtedly constitute a sound basis to clinically apply uterine
      transplantation in the near future. This paper is, however, an overview not only 
      of the extent and limitations of accumulated scientific knowledge on uterine
      transplantation, but also its ethical implications, in an effort to define the
      actual place of such an approach among the therapeutic arsenal for alleviating
      infertility.
CI  - (c) 2011 New York Academy of Sciences.
FAU - Grynberg, Michael
AU  - Grynberg M
AD  - AP-HP, Service de Gynecologie-Obstetrique et Medecine de la Reproduction, Hopital
      Antoine Beclere, Clamart, France.
FAU - Ayoubi, Jean-Marc
AU  - Ayoubi JM
FAU - Bulletti, Carlo
AU  - Bulletti C
FAU - Frydman, Rene
AU  - Frydman R
FAU - Fanchin, Renato
AU  - Fanchin R
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
SB  - IM
MH  - Female
MH  - Humans
MH  - Infertility, Female/*surgery/therapy
MH  - Pregnancy
MH  - Surrogate Mothers
MH  - Uterus/abnormalities/physiology/*surgery/*transplantation
EDAT- 2011/03/16 06:00
MHDA- 2011/05/07 06:00
CRDT- 2011/03/16 06:00
PHST- 2011/03/16 06:00 [entrez]
PHST- 2011/03/16 06:00 [pubmed]
PHST- 2011/05/07 06:00 [medline]
AID - 10.1111/j.1749-6632.2011.05952.x [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2011 Mar;1221:47-53. doi: 10.1111/j.1749-6632.2011.05952.x.


PMID- 21401465
OWN - NLM
STAT- MEDLINE
DCOM- 20110524
LR  - 20201230
IS  - 1326-5377 (Electronic)
IS  - 0025-729X (Linking)
VI  - 194
IP  - 4
DP  - 2011 Feb 21
TI  - Mandatory reporting, doctors' health and ethical obligations.
PG  - 205
FAU - Parker, Malcolm H
AU  - Parker MH
LA  - eng
PT  - Letter
PL  - Australia
TA  - Med J Aust
JT  - The Medical journal of Australia
JID - 0400714
SB  - IM
MH  - Australia
MH  - *Ethics, Medical
MH  - Humans
MH  - *Mandatory Programs/ethics/legislation & jurisprudence
MH  - *Physician Impairment/legislation & jurisprudence
EDAT- 2011/03/16 06:00
MHDA- 2011/05/25 06:00
CRDT- 2011/03/16 06:00
PHST- 2010/10/21 00:00 [received]
PHST- 2010/11/29 00:00 [accepted]
PHST- 2011/03/16 06:00 [entrez]
PHST- 2011/03/16 06:00 [pubmed]
PHST- 2011/05/25 06:00 [medline]
AID - letters_210211_fm-1 [pii]
AID - 10.5694/j.1326-5377.2011.tb03775.x [doi]
PST - ppublish
SO  - Med J Aust. 2011 Feb 21;194(4):205. doi: 10.5694/j.1326-5377.2011.tb03775.x.


PMID- 21382851
OWN - NLM
STAT- MEDLINE
DCOM- 20110321
LR  - 20191210
IS  - 1651-1905 (Electronic)
IS  - 1403-4948 (Linking)
VI  - 39
IP  - 6 Suppl
DP  - 2011 Mar
TI  - Developing health promotion education: mainstreaming or acknowledging tensions in
      an evolving discipline?
PG  - 79-84
LID - 10.1177/1403494810384428 [doi]
AB  - AIMS: To contribute to development of global frameworks for health promotion
      education, by means of constructive criticism of the Galway Consensus Conference 
      Statement (GCCS), and, furthermore, to substantiate that such frameworks must
      transcend political trends if they are to contribute to the ongoing development
      of health promotion both as a discipline and as a professional practice. This
      article is based on a workshop on competence domains in health promotion, held at
      the Sixth Nordic Health Promotion Research Conference in Gothenburg, Sweden,
      20-22 August 2009. METHODS: The GCCS's delimitations of health, health promotion,
      and health promotion ethics is analysed and contrasted with the authors' ongoing 
      experiences from a master's programme in health promotion. RESULTS: Three
      important limitations in the GCCS are identified: the GCCS does not promote
      perspectives on health other than absence of disease, defines no role for health 
      promotion other than disease prevention, and includes no perspectives on ethical 
      challenges for practitioners. The examples from the master's programme illustrate
      how and why these delimitations are problematic. CONCLUSIONS: Despite its
      limitations the GCCS has the potential to set a global agenda for health
      promotion education because of its emphasis on domains of core competencies in
      health promotion practice. To further this potential the GCCS' context of use
      should be changed from mainstreaming health promotion into a technology for
      disease prevention, to enabling dialog between contributors to health promotion
      with differing political and scientific ideals. Such dialog must relate to
      tensions and ambiguities experienced by health promotion practitioners in
      real-life situations.
FAU - Hauge, Hans A
AU  - Hauge HA
AD  - Vestfold University College, Faculty of Health Science, Research Centre for
      Health Promotion in Settings, Tonsberg, Norway. Hans.Hauge@hive.no
FAU - Hem, Hans Einar
AU  - Hem HE
LA  - eng
PT  - Journal Article
PL  - Sweden
TA  - Scand J Public Health
JT  - Scandinavian journal of public health
JID - 100883503
SB  - IM
MH  - Consensus
MH  - *Health Education/trends
MH  - Health Policy
MH  - *Health Promotion/trends
MH  - Humans
MH  - *Mainstreaming, Education/trends
MH  - Professional Competence
MH  - Public Health
EDAT- 2011/03/16 06:00
MHDA- 2011/03/22 06:00
CRDT- 2011/03/09 06:00
PHST- 2011/03/09 06:00 [entrez]
PHST- 2011/03/16 06:00 [pubmed]
PHST- 2011/03/22 06:00 [medline]
AID - 39/6_suppl/79 [pii]
AID - 10.1177/1403494810384428 [doi]
PST - ppublish
SO  - Scand J Public Health. 2011 Mar;39(6 Suppl):79-84. doi: 10.1177/1403494810384428.


PMID- 21400380
OWN - NLM
STAT- MEDLINE
DCOM- 20110516
LR  - 20110314
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 11
IP  - 3
DP  - 2011 Mar
TI  - An obscure rider obstructing science: the conflation of parthenotes with embryos 
      in the Dickey-Wicker amendment.
PG  - 20-8
LID - 10.1080/15265161.2010.546472 [doi]
AB  - In 1996 Congress passed the Dickey-Wicker Amendment (DWA) as part of an
      appropriations bill; it has been renewed every year since. The DWA bans federal
      funding for research using embryos and parthenotes. In this paper, we call for a 
      public discussion on parthenote research and a questioning of its inclusion in
      the DWA. We begin by explaining what parthenotes are and why they are useful for 
      research on reproduction, cancer, and stem cells. We then argue that the
      scientific difference between embryos and parthenotes translates into ethical
      differences, and claim that research on parthenotes is much less ethically
      problematic. Finally, we contextualize the original passage of the DWA to provide
      an explanation for why the two were possibly conflated in this law. We conclude
      by calling for a public discussion on reconsidering the DWA in its entirety,
      starting with the removal of parthenogenesis from this prohibition of National
      Institutes of Health (NIH) funding.
FAU - Rodriguez, Sarah
AU  - Rodriguez S
AD  - Oncofertility Consortium, Northwestern University, 303 E. Superior, Chicago, IL
      60611, USA.
FAU - Campo-Engelstein, Lisa
AU  - Campo-Engelstein L
FAU - Tingen, Candace
AU  - Tingen C
FAU - Woodruff, Teresa
AU  - Woodruff T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CIN - Am J Bioeth. 2011 Mar;11(3):1. PMID: 21400372
CIN - Am J Bioeth. 2011 Mar;11(3):W1-2. PMID: 21400373
CIN - Am J Bioeth. 2011 Mar;11(3):29-30. PMID: 21400381
CIN - Am J Bioeth. 2011 Mar;11(3):31-2. PMID: 21400382
CIN - Am J Bioeth. 2011 Mar;11(3):33-5. PMID: 21400383
CIN - Am J Bioeth. 2011 Mar;11(3):35-6. PMID: 21400384
CIN - Am J Bioeth. 2011 Mar;11(3):37-9. PMID: 21400385
MH  - Embryo Research/*economics/*ethics/legislation & jurisprudence
MH  - Embryo, Mammalian
MH  - Financing, Government/*legislation & jurisprudence
MH  - Humans
MH  - Moral Obligations
MH  - *Parthenogenesis
MH  - Research Support as Topic/*legislation & jurisprudence
MH  - United States
EDAT- 2011/03/15 06:00
MHDA- 2011/05/17 06:00
CRDT- 2011/03/15 06:00
PHST- 2011/03/15 06:00 [entrez]
PHST- 2011/03/15 06:00 [pubmed]
PHST- 2011/05/17 06:00 [medline]
AID - 934749129 [pii]
AID - 10.1080/15265161.2010.546472 [doi]
PST - ppublish
SO  - Am J Bioeth. 2011 Mar;11(3):20-8. doi: 10.1080/15265161.2010.546472.


PMID- 21400354
OWN - NLM
STAT- MEDLINE
DCOM- 20110531
LR  - 20110314
IS  - 1545-5882 (Electronic)
IS  - 0145-9740 (Linking)
VI  - 30
IP  - 2
DP  - 2011 Mar
TI  - The rings around Jonathan's eyes: HIV/AIDS medicine at the margins of
      administration.
PG  - 222-39
LID - 10.1080/01459740.2011.552452 [doi]
AB  - In this article I explore how a medical protocol is encountered by a doctor
      practicing in a South African setting. I examine how the attempt at standardizing
      medical services is simultaneously challenged and upheld within medical practice 
      by illustrating the cognitivist assumptions upon which standardizing medical
      decision making is based, and showing how this is a product of a particular
      history of thought. This is challenged by the practice of medicine. I then
      explore the ethical implications of standardization. The case studies demonstrate
      that relationships between doctors and patients do not fit necessarily into the
      pre-established categories created by protocols.
CI  - Copyright (c) 2011 Taylor & Francis Group, LLC
FAU - Human, Oliver
AU  - Human O
AD  - Department of Sociology and Social Anthropology, Stellenbosch University, South
      Africa. olhuman@gmail.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Anthropol
JT  - Medical anthropology
JID - 7707343
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/*drug therapy
MH  - *Decision Making
MH  - HIV Infections/*drug therapy
MH  - Humans
MH  - Logic
MH  - Male
MH  - Practice Management, Medical/*standards
MH  - South Africa
EDAT- 2011/03/15 06:00
MHDA- 2011/06/01 06:00
CRDT- 2011/03/15 06:00
PHST- 2011/03/15 06:00 [entrez]
PHST- 2011/03/15 06:00 [pubmed]
PHST- 2011/06/01 06:00 [medline]
AID - 934837724 [pii]
AID - 10.1080/01459740.2011.552452 [doi]
PST - ppublish
SO  - Med Anthropol. 2011 Mar;30(2):222-39. doi: 10.1080/01459740.2011.552452.


PMID- 21400352
OWN - NLM
STAT- MEDLINE
DCOM- 20110531
LR  - 20211020
IS  - 1545-5882 (Electronic)
IS  - 0145-9740 (Linking)
VI  - 30
IP  - 2
DP  - 2011 Mar
TI  - Dynamics of care, situations of choice: HIV tests in times of ART.
PG  - 183-201
LID - 10.1080/01459740.2011.552455 [doi]
AB  - In the 1990s, African AIDS programs followed a voluntary counseling and testing
      (VCT) approach to HIV testing. In the wake of large scale AIDS treatment
      programs, policymakers opted for routine provider-initiated testing (PITC) with
      less emphasis on counseling, which led to concerns about the ethical conduct of
      HIV testing. Inspired by Annemarie Mol, we ask if PITC can be framed as good
      care, rather than as medical domination that threatens to violate patients'
      rights. Based on fieldwork in Ugandan and Kenyan health facilities, we reveal
      that situations of choice vary: patients in hospital wards, are given time to
      decide whether they want a test, while in antenatal care testing women find it
      very hard to opt-out. We argue that the medical context inherent in PITC provides
      an attractive moral space for people to undergo HIV tests.
CI  - Copyright (c) 2011 Taylor & Francis Group, LLC
FAU - Hardon, Anita
AU  - Hardon A
AD  - Amsterdam Institute for Social Science Research (AISSR), University of Amsterdam,
      Amsterdam, The Netherlands. a.p.hardon@uva.nl
FAU - Kageha, Emmy
AU  - Kageha E
FAU - Kinsman, John
AU  - Kinsman J
FAU - Kyaddondo, David
AU  - Kyaddondo D
FAU - Wanyenze, Rhoda
AU  - Wanyenze R
FAU - Obermeyer, Carla Makhlouf
AU  - Obermeyer CM
LA  - eng
GR  - R01 HD053268/HD/NICHD NIH HHS/United States
GR  - 5 R01HD053268-05/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Med Anthropol
JT  - Medical anthropology
JID - 7707343
RN  - 0 (Anti-Retroviral Agents)
SB  - IM
MH  - AIDS Serodiagnosis
MH  - Anti-Retroviral Agents/therapeutic use
MH  - Counseling
MH  - Female
MH  - HIV/isolation & purification
MH  - HIV Infections/*diagnosis/*drug therapy/virology
MH  - Health Knowledge, Attitudes, Practice
MH  - *Health Policy
MH  - Hospitals
MH  - Humans
MH  - Kenya
MH  - Male
MH  - Mass Screening/methods
MH  - Uganda
MH  - *Voluntary Programs
PMC - PMC4260149
MID - NIHMS636318
EDAT- 2011/03/15 06:00
MHDA- 2011/06/01 06:00
CRDT- 2011/03/15 06:00
PHST- 2011/03/15 06:00 [entrez]
PHST- 2011/03/15 06:00 [pubmed]
PHST- 2011/06/01 06:00 [medline]
AID - 934841135 [pii]
AID - 10.1080/01459740.2011.552455 [doi]
PST - ppublish
SO  - Med Anthropol. 2011 Mar;30(2):183-201. doi: 10.1080/01459740.2011.552455.


PMID- 21400219
OWN - NLM
STAT- MEDLINE
DCOM- 20110816
LR  - 20211020
IS  - 1573-0980 (Electronic)
IS  - 1386-7415 (Linking)
VI  - 32
IP  - 3
DP  - 2011 Jun
TI  - What we worry about when we worry about the ethics of clinical research.
PG  - 161-80
LID - 10.1007/s11017-011-9176-y [doi]
AB  - Clinical research is thought to be ethically problematic and is subject to
      extensive regulation and oversight. Despite frequent endorsement of this view,
      there has been almost no systematic evaluation of why clinical research might be 
      ethically problematic. As a result, it is difficult to determine whether the
      regulations to which clinical research is subject address the ethical concerns it
      raises. Commentators who consider this question at all tend to assume that
      clinical research is ethically problematic because it exposes some individuals to
      risks for the benefit of others. Yet, many other activities that expose some
      individuals to risks for the benefit of others are not subject to extensive
      regulation and oversight. This difference raises the question of whether clinical
      research is distinct from these activities in normatively relevant ways and, if
      so, what implications this difference (or differences) has for how clinical
      research should be regulated and conducted. The present manuscript attempts to
      answer this question by comparing clinical research to two other activities that 
      expose some individuals to risks for the benefit of others. This comparison
      highlights an aspect of clinical research which has received relatively little
      attention, namely, the active role investigators play in exposing subjects to
      risks. I argue that this aspect explains much of the ethical concern expressed
      regarding clinical research. I end by considering the normative significance of
      this feature and the implications it has for how clinical research should be
      regulated and conducted.
FAU - Wendler, David
AU  - Wendler D
AD  - Department of Bioethics, NIH Clinical Center, Building 10, Room 1C118, Bethesda, 
      MD 20892, USA. dwendler@nih.gov
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Theor Med Bioeth
JT  - Theoretical medicine and bioethics
JID - 9805378
SB  - IM
MH  - Biomedical Research/*ethics
MH  - *Ethics, Research
MH  - Humans
MH  - Industry
MH  - Informed Consent/ethics
MH  - Nontherapeutic Human Experimentation/ethics
MH  - Pediatrics
MH  - Research Design
MH  - Research Personnel/*ethics
MH  - Vulnerable Populations
EDAT- 2011/03/15 06:00
MHDA- 2011/08/17 06:00
CRDT- 2011/03/15 06:00
PHST- 2011/03/15 06:00 [entrez]
PHST- 2011/03/15 06:00 [pubmed]
PHST- 2011/08/17 06:00 [medline]
AID - 10.1007/s11017-011-9176-y [doi]
PST - ppublish
SO  - Theor Med Bioeth. 2011 Jun;32(3):161-80. doi: 10.1007/s11017-011-9176-y.


PMID- 21399970
OWN - NLM
STAT- MEDLINE
DCOM- 20120316
LR  - 20220408
IS  - 1708-0428 (Electronic)
IS  - 0960-8923 (Linking)
VI  - 21
IP  - 10
DP  - 2011 Oct
TI  - Morbidity in patients with or at high risk for obstructive sleep apnea after
      ambulatory laparoscopic gastric banding.
PG  - 1494-8
LID - 10.1007/s11695-011-0381-6 [doi]
AB  - Considerable controversy exists about the perioperative management of patients at
      high risk for obstructive sleep apnea (OSA) in free-standing clinics.
      Eighty-eight percent of an American Society of Anesthesiologists expert panel
      felt that upper abdominal laparoscopic surgery could not be performed safely on
      an outpatient basis. We sought to review the incidence of major adverse events
      after outpatient laparoscopic adjustable gastric banding (LAGB) in a high risk
      population for OSA at a free-standing facility. Research Ethics Board approval
      was obtained and charts were reviewed retrospectively for 2,370 LAGB performed at
      a free-standing clinic between 2005 and 2009. In this observational cohort study,
      patients were classified as high risk for OSA if they received continuous
      positive airway pressure (CPAP) treatment for OSA pre-operatively or had a
      history of at least three STOP-BANG criteria. Follow-up was verified and adverse 
      events reviewed, including death, unanticipated transfer or admission to hospital
      within 30 days. A total of 746 of the 2,370 patients (31%) met criteria for or
      were at high risk for OSA (357 received CPAP for OSA and 389 by STOP-BANG
      criteria). The incidence of transient desaturation to less than 93% was 39.5%.
      There were no deaths and no cases of respiratory failure or re-intubation. The
      30-day mortality was zero and the 30-day anesthesia related morbidity was less
      than 0.5%. For patients at high risk for OSA after LAGB, the significance of
      transient oxygen desaturation and the need to develop monitoring and admission
      standards remain to be determined.
FAU - Kurrek, Matt M
AU  - Kurrek MM
AD  - Department of Anesthesia, University of Toronto, 150 College Street, Fitzgerald
      Building, Room 121, Toronto, Ontario, M5S 3E2, Canada. m.kurrek@utoronto.ca
FAU - Cobourn, Chris
AU  - Cobourn C
FAU - Wojtasik, Ziggy
AU  - Wojtasik Z
FAU - Kiss, Alexander
AU  - Kiss A
FAU - Dain, Steven L
AU  - Dain SL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Obes Surg
JT  - Obesity surgery
JID - 9106714
SB  - IM
MH  - Adult
MH  - Ambulatory Surgical Procedures
MH  - Comorbidity
MH  - Female
MH  - Gastroplasty/*adverse effects
MH  - Humans
MH  - Incidence
MH  - Laparoscopy
MH  - Male
MH  - Middle Aged
MH  - Morbidity
MH  - Obesity/*epidemiology/surgery
MH  - Sleep Apnea, Obstructive/*epidemiology
MH  - Young Adult
EDAT- 2011/03/15 06:00
MHDA- 2012/03/17 06:00
CRDT- 2011/03/15 06:00
PHST- 2011/03/15 06:00 [entrez]
PHST- 2011/03/15 06:00 [pubmed]
PHST- 2012/03/17 06:00 [medline]
AID - 10.1007/s11695-011-0381-6 [doi]
PST - ppublish
SO  - Obes Surg. 2011 Oct;21(10):1494-8. doi: 10.1007/s11695-011-0381-6.


PMID- 21399544
OWN - NLM
STAT- MEDLINE
DCOM- 20111130
LR  - 20211203
IS  - 1529-8809 (Electronic)
IS  - 0022-5282 (Linking)
VI  - 71
IP  - 4
DP  - 2011 Oct
TI  - Insurance status and hospital discharge disposition after trauma: inequities in
      access to postacute care.
PG  - 1011-5
LID - 10.1097/TA.0b013e3182092c27 [doi]
AB  - BACKGROUND: Postacute care is an essential component of medical care aimed at
      returning trauma patients to their preinjury functional status. Rehabilitation
      services, skilled nursing facilities, and home care all play a role in
      facilitating the healing process. Access to such care may be limited based on
      insurance status, leaving the uninsured with limited resources to reach full
      recovery. We hypothesized that access to specialized postacute care is less
      available to patients who lack health insurance. METHODS: A retrospective cohort 
      of trauma patients in the National Trauma Databank from 2002 to 2006 was assessed
      to determine whether insurance status was a predictor of discharge to a
      specialized postacute care facility (rehabilitation, skilled nursing facilities, 
      and home health). Using multivariate logistic regression, we assessed the
      likelihood of discharge to such facilities on the basis of insurance status,
      controlling for patient demographics and injury severity. RESULTS: Adjusting for 
      variation in age, race/ethicity, gender, and injury type and severity, uninsured 
      patients had the lowest odds of being discharged to a skilled nursing facility
      (odds ratio [OR], 0.76; 95% confidence interval [CI] 0.73-0.80; p<0.001), home
      health (OR, 0.51; 95% CI 0.49-0.53; p<0.001), and rehabilitation (OR, 0.45; 95%
      CI 0.44-0.46; p<0.001). Uninsured patients had the highest odds, however, of
      being discharged directly home (OR, 1.32; 95% CI 1.30-1.34; p<0.001). CONCLUSION:
      Insurance status is an important predictor of hospital disposition and access to 
      specialized posthospital care. Uninsured patients are less likely to have access 
      to the full range of medical care available to ensure complete recovery from
      traumatic injuries.
FAU - Sacks, Greg D
AU  - Sacks GD
AD  - Department of Health Policy and Management, Center for Surgery and Public Health,
      Harvard School of Public Health, and Division of Burn, Trauma, and Surgical
      Critical Care, Department of Surgery, Center for Surgery and Public Health,
      Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
FAU - Hill, Caterina
AU  - Hill C
FAU - Rogers, Selwyn O Jr
AU  - Rogers SO Jr
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Trauma
JT  - The Journal of trauma
JID - 0376373
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Confidence Intervals
MH  - Databases, Factual
MH  - Female
MH  - Health Services Accessibility/statistics & numerical data
MH  - *Healthcare Disparities/statistics & numerical data
MH  - Hispanic or Latino/statistics & numerical data
MH  - Humans
MH  - Injury Severity Score
MH  - *Insurance Coverage/statistics & numerical data
MH  - *Insurance, Health/statistics & numerical data
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Odds Ratio
MH  - Patient Discharge/statistics & numerical data
MH  - Racial Groups/statistics & numerical data
MH  - Regression Analysis
MH  - Retrospective Studies
MH  - Trauma Centers/statistics & numerical data
MH  - United States
MH  - Wounds and Injuries/*rehabilitation
MH  - Young Adult
EDAT- 2011/03/15 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/03/15 06:00
PHST- 2011/03/15 06:00 [entrez]
PHST- 2011/03/15 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1097/TA.0b013e3182092c27 [doi]
PST - ppublish
SO  - J Trauma. 2011 Oct;71(4):1011-5. doi: 10.1097/TA.0b013e3182092c27.


PMID- 21399420
OWN - NLM
STAT- MEDLINE
DCOM- 20110512
LR  - 20110314
IS  - 1538-5159 (Electronic)
IS  - 0017-9078 (Linking)
VI  - 100
IP  - 1
DP  - 2011 Jan
TI  - Role of the International Radiation Protection Association.
PG  - 103-6
LID - 10.1097/HP.0b013e3181f56d14 [doi]
AB  - Global concerns over energy supply and climate change have given rise to an
      increase in uranium prospecting, mining and extraction. The changing world
      economy is spreading the use of advanced nuclear and radiation-related
      technologies to many parts of the world, giving rise to global initiatives on
      nuclear energy and operation of nuclear fuel cycle facilities. The emerging
      global nuclear safety regime promotes and encourages high standards of radiation 
      safety worldwide. These developments call for increasing capacity and
      capabilities in radiation protection expertise and continue to present both
      challenges and opportunities to the International Radiation Protection
      Association (IRPA), an association of 46 societies representing 58 countries with
      an individual membership of approximately 17,000. IRPA's objectives include: (1) 
      assisting the development of competent radiation protection programs; (2)
      fostering the exchange of scientific and technical information through its
      international and regional congresses; (3) promoting the scientific and
      professional recognition of the radiation protection expert; and (4) supporting
      continuing education programs at each IRPA congress. IRPA has adopted a Code of
      Ethics and Guiding Principles for the Conduct of Stakeholder Engagement. Recently
      work began to develop guidance for maintaining and improving current levels of
      radiation protection and transferring this culture to future radiation protection
      professionals. These IRPA projects are developed through the Associate Society
      Forum discussions that are held at each IRPA international and regional congress.
      Finally, IRPA maintains a close working relationship with various international
      organizations and is also represented on the Inter-Agency Committee on Radiation 
      Safety.
CI  - Copyright (c) 2010 Health Physics Society
FAU - Kase, Kenneth R
AU  - Kase KR
AD  - International Radiation Protection Association, 28 rue de la Redoute, F-92260,
      Fontenay-aux-Roses, France. kr.kase@stanfordalumni.org
FAU - Metcalf, Phil
AU  - Metcalf P
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Health Phys
JT  - Health physics
JID - 2985093R
SB  - IM
MH  - Communication
MH  - Education
MH  - International Agencies/legislation & jurisprudence/*organization & administration
MH  - Internationality
MH  - Organizational Objectives
MH  - *Radiation Protection/legislation & jurisprudence/methods/standards
MH  - Societies/organization & administration
EDAT- 2011/03/15 06:00
MHDA- 2011/05/13 06:00
CRDT- 2011/03/15 06:00
PHST- 2011/03/15 06:00 [entrez]
PHST- 2011/03/15 06:00 [pubmed]
PHST- 2011/05/13 06:00 [medline]
AID - 10.1097/HP.0b013e3181f56d14 [doi]
AID - 00004032-201101000-00019 [pii]
PST - ppublish
SO  - Health Phys. 2011 Jan;100(1):103-6. doi: 10.1097/HP.0b013e3181f56d14.


PMID- 21399409
OWN - NLM
STAT- MEDLINE
DCOM- 20110512
LR  - 20110314
IS  - 1538-5159 (Electronic)
IS  - 0017-9078 (Linking)
VI  - 100
IP  - 1
DP  - 2011 Jan
TI  - Radiation protection at U.S. nuclear power plants--today and tomorrow.
PG  - 35-8
LID - 10.1097/HP.0b013e3181f6590d [doi]
AB  - The nuclear power industry work ethic and culture is founded on learning from
      experience and continuously finding ways to improve performance--especially in
      regard to radiation safety. Over the past 25 y, this process of continuous
      improvement has yielded exceptional results in regard to radiation protection of 
      workers, the public and the environment. In light of the resurgence of nuclear
      energy in the United States, the nuclear power industry is developing strategies 
      to achieve continuous improvements to performance and address emerging challenges
      in the area of radiation protection.
CI  - Copyright (c) 2010 Health Physics Society
FAU - Blevins, Michael R
AU  - Blevins MR
AD  - Luminant Power, Dallas, TX 75201, USA. mike.blevins@luminant.com
FAU - Andersen, Ralph L
AU  - Andersen RL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Health Phys
JT  - Health physics
JID - 2985093R
SB  - IM
MH  - Conservation of Natural Resources
MH  - Humans
MH  - International Agencies/standards
MH  - Nuclear Power Plants/standards/*statistics & numerical data
MH  - Occupational Exposure/prevention & control/standards
MH  - Perception
MH  - Radiation Dosage
MH  - Radiation Protection/standards/*statistics & numerical data
MH  - United States
EDAT- 2011/03/15 06:00
MHDA- 2011/05/13 06:00
CRDT- 2011/03/15 06:00
PHST- 2011/03/15 06:00 [entrez]
PHST- 2011/03/15 06:00 [pubmed]
PHST- 2011/05/13 06:00 [medline]
AID - 10.1097/HP.0b013e3181f6590d [doi]
AID - 00004032-201101000-00008 [pii]
PST - ppublish
SO  - Health Phys. 2011 Jan;100(1):35-8. doi: 10.1097/HP.0b013e3181f6590d.


PMID- 21398390
OWN - NLM
STAT- MEDLINE
DCOM- 20110908
LR  - 20110520
IS  - 1758-1109 (Electronic)
IS  - 1357-633X (Linking)
VI  - 17
IP  - 4
DP  - 2011
TI  - The use of email as a component of adult stammering therapy: a preliminary
      report.
PG  - 163-7
LID - 10.1258/jtt.2010.100114 [doi]
AB  - In West Glasgow email has evolved from a rapid means of arranging therapy
      appointments with adults who stammer into a medium for exchange of therapeutic
      messages with some clients. Since 2004, sixteen clients have used email to
      communicate as part of their therapy programme. The benefits include improving
      access to services, supporting speech change, facilitating lasting personal
      growth, improving clinical decision-making, equalizing the therapist-client
      relationship and enhancing caseload management. Although this experience suggests
      that email is appropriate for stammering therapy, the effectiveness and ethics
      of, and the rationale for, clinical practice that includes email need careful
      consideration. Further research is required to formally evaluate the client
      experience.
FAU - Allen, Carolyn R
AU  - Allen CR
AD  - Speech and Language Therapy, University of Strathclyde, Glasgow G13 1PP, UK.
      carolyn.allen@strath.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20110311
PL  - England
TA  - J Telemed Telecare
JT  - Journal of telemedicine and telecare
JID - 9506702
SB  - IM
MH  - Adult
MH  - Communication
MH  - Decision Making
MH  - *Electronic Mail
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Professional-Patient Relations
MH  - Speech Therapy/*education
MH  - Stuttering/*therapy
MH  - Treatment Outcome
EDAT- 2011/03/15 06:00
MHDA- 2011/09/09 06:00
CRDT- 2011/03/15 06:00
PHST- 2011/03/15 06:00 [entrez]
PHST- 2011/03/15 06:00 [pubmed]
PHST- 2011/09/09 06:00 [medline]
AID - jtt.2010.100114 [pii]
AID - 10.1258/jtt.2010.100114 [doi]
PST - ppublish
SO  - J Telemed Telecare. 2011;17(4):163-7. doi: 10.1258/jtt.2010.100114. Epub 2011 Mar
      11.


PMID- 21397771
OWN - NLM
STAT- MEDLINE
DCOM- 20110629
LR  - 20171116
IS  - 1879-114X (Electronic)
IS  - 0149-2918 (Linking)
VI  - 33
IP  - 1
DP  - 2011 Jan
TI  - Clinical effectiveness of biphasic insulin aspart 30:70 versus biphasic human
      insulin 30 in UK general clinical practice: a retrospective database study.
PG  - 27-35
LID - 10.1016/j.clinthera.2011.01.023 [doi]
AB  - BACKGROUND: Premixed, or biphasic, insulins containing varying proportions of
      rapid- and intermediate-acting insulin components have been developed to limit
      the number of daily injections for patients who require both prandial and basal
      insulin injections. OBJECTIVES: This study was conducted to determine whether
      there were differences in glycosylated hemoglobin (HbA(1c)), weight change,
      hypoglycemia occurrence, and treatment discontinuation between patients treated
      with biphasic insulin aspart 30 (BIAsp-30) or biphasic human insulin 30 (BHI-30) 
      in UK general practice. METHODS: Data were from >350 general practices from the
      United Kingdom. Patients were stratified by treatment regimen, diabetes type, and
      insulin status (naive or experienced). Changes in HbA(1c) and weight were
      compared from baseline (the date of the first prescription for either insulin)
      through 180 days of follow-up using ANCOVA. Hypoglycemia incidence rate ratios
      were compared, and the adjusted likelihood of hypoglycemia was evaluated by
      logistic regression. Rates of treatment discontinuation were compared using the
      Cox proportional hazards model. RESULTS: The study included data from 7720
      patients, of whom 1333 (17.3%) had type 1 diabetes and 4457 (57.7%) were male.
      Patients' mean (SD) age was 57.9 (19.8) years, and their mean body mass index was
      29.5 (6.2) kg/m(2). The difference in HbA(1c) reduction was significant for
      BIAsp-30 compared with BHI-30 in insulin-naive patients with type 1 diabetes
      (0.57%; P = 0.045), insulin-naive patients with type 2 diabetes (-0.17%; P =
      0.003), and insulin-experienced patients with type 2 diabetes (-0.23%; P =
      0.007). The difference between insulins was not significant in
      insulin-experienced patients with type 1 diabetes. Five hundred ninety-four
      patients (7.7%) experienced at least one hypoglycemic event. The incidence rate
      ratio for reported hypoglycemia was significantly lower with BIAsp-30 compared
      with BHI-30 in insulin-naive patients with type 2 diabetes (0.74; 95% CI,
      0.62-0.89; P = 0.001); the difference between insulins was not significant in the
      other groups. The adjusted hazard ratio for treatment discontinuation was
      significant for BIAsp-30 versus BHI-30 in insulin-experienced patients with type 
      2 diabetes (0.693; 95% CI, 0.543-0.884; P = 0.003), whereas the hazard ratios for
      the other groups did not reach statistical significance. There were no
      significant differences in weight change between BIAsp-30 and BHI-30 in any of
      the groups. CONCLUSIONS: In this analysis, BIAsp-30 was associated with improved 
      glycemic control (HbA(1c)) compared with BHI-30 in insulin-naive patients with
      type 1 or type 2 diabetes and insulin-experienced patients with type 2 diabetes. 
      BIAsp-30 was associated with reduced hypoglycemia in insulin-naive patients with 
      type 2 diabetes and lower rates of treatment discontinuation in
      insulin-experienced patients with type 2 diabetes. Cambridgeshire Research Ethics
      Committee: REC 08/H0305/47.
CI  - Copyright (c) 2011. Published by EM Inc USA.
FAU - Morgan, Christopher Ll
AU  - Morgan CL
AD  - Department of Epidemiology, Pharmatelligence, Cardiff, United Kingdom.
FAU - Evans, Marc
AU  - Evans M
FAU - Toft, Anders D
AU  - Toft AD
FAU - Jenkins-Jones, Sara
AU  - Jenkins-Jones S
FAU - Poole, Chris D
AU  - Poole CD
FAU - Currie, Craig J
AU  - Currie CJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Clin Ther
JT  - Clinical therapeutics
JID - 7706726
RN  - 0 (Biphasic Insulins)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
RN  - 0 (insulin aspart, insulin aspart protamine drug combination 30:70)
RN  - 53027-39-7 (Insulin, Isophane)
RN  - D933668QVX (Insulin Aspart)
SB  - IM
EIN - Clin Ther. 2011 Mar;33(3):391
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Analysis of Variance
MH  - Biphasic Insulins
MH  - Body Weight
MH  - Child
MH  - Databases, Factual
MH  - Diabetes Mellitus, Type 1/*drug therapy
MH  - Diabetes Mellitus, Type 2/*drug therapy
MH  - Female
MH  - Glycated Hemoglobin A/metabolism
MH  - Humans
MH  - Hypoglycemia/chemically induced
MH  - Hypoglycemic Agents/*administration & dosage/adverse effects
MH  - Insulin/administration & dosage/adverse effects/*analogs & derivatives
MH  - Insulin Aspart
MH  - Insulin, Isophane
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Treatment Outcome
MH  - United Kingdom
MH  - Young Adult
EDAT- 2011/03/15 06:00
MHDA- 2011/06/30 06:00
CRDT- 2011/03/15 06:00
PHST- 2010/10/08 00:00 [accepted]
PHST- 2011/03/15 06:00 [entrez]
PHST- 2011/03/15 06:00 [pubmed]
PHST- 2011/06/30 06:00 [medline]
AID - S0149-2918(11)00070-1 [pii]
AID - 10.1016/j.clinthera.2011.01.023 [doi]
PST - ppublish
SO  - Clin Ther. 2011 Jan;33(1):27-35. doi: 10.1016/j.clinthera.2011.01.023.


PMID- 21397558
OWN - NLM
STAT- MEDLINE
DCOM- 20150702
LR  - 20211020
IS  - 1472-6491 (Electronic)
IS  - 1472-6483 (Linking)
VI  - 22
IP  - 5
DP  - 2011 May
TI  - The politics of human embryo research and the motivation to achieve PGD.
PG  - 457-71
LID - 10.1016/j.rbmo.2011.01.008 [doi]
AB  - This article reports a historical study of factors influencing the achievement of
      clinical preimplantation genetic diagnosis (PGD) in 1990, 22 years after its
      first demonstration in animals. During the 1970s, research on PGD continued in
      large farm animals, but serious interest in human PGD was not evident until 1986.
      First, interest in PGD during the 1970s waned with the advent of prenatal
      testing, which for gynaecologists was clinically more familiar, technically
      simpler and ethically less challenging than IVF. Indeed, IVF was viewed with
      widespread suspicion until the first IVF births in 1978. Second, interest in
      clinical PGD was stimulated by the UK Parliamentary reaction against human embryo
      research that greeted the Warnock Report in 1984. This hostility led scientists
      to initiate a pro-research campaign, further galvanized in 1985 by MP Enoch
      Powell's bid to ban such research. However, while Powell abhorred embryo
      research, he approved of PGD, a stance that divided the anti-research lobby.
      Accordingly, the campaigners for research emphasized that it was needed to
      achieve PGD. Powell demanded evidence of such projects and PGD research increased
      from 1986. It is concluded that UK political debates on embryo research played a 
      critical role in stimulating the achievement of clinical PGD. Human pregnancies
      following preimplantation genetic diagnosis (PGD) for embryo sex were announced
      in 1990, 22 years after the technique was pioneered in animals. PGD in humans
      required not only technological advances, such as IVF and sensitive diagnostic
      tests, but also the motivation to develop and apply them. Our historical analysis
      shows that, although research on PGD continued in large farm animals during the
      1970s, and techniques of the required sensitivity were developed on mouse embryo 
      models, interest in clinical PGD was not evident until 1986. Two factors
      stimulated this sudden change in motivation. First, interest in PGD was depressed
      during the 1970s by the advent of prenatal diagnostic techniques, which for
      gynaecologists were clinically, technically and ethically less challenging than
      IVF. IVF was then regarded with a suspicion that only started to wane in the
      early 1980s following the first IVF births. Second, the UK Parliamentary reaction
      against human embryo research that greeted the Warnock Report in 1984 provided a 
      positive stimulus to clinical PGD by prompting scientists to form a pro-research 
      lobby, which was further galvanized in early 1985 by MP Enoch Powell's
      almost-successful bid to ban human embryo research. We show that while Powell
      abhorred embryo research, he approved of PGD, a stance that fractured the unity
      of the anti-research lobby. Accordingly, the pro-research lobby emphasized that
      embryo research was needed to achieve PGD. Powell demanded evidence of such
      projects, thereby, we argue, stimulating PGD research from 1986. Our evidence
      shows that UK political debates about PGD played a critical role in stimulating
      the achievement of PGD clinically.
CI  - Copyright (c) 2011 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All
      rights reserved.
FAU - Theodosiou, Anastasia A
AU  - Theodosiou AA
AD  - Anatomy School and Trophoblast Research Centre, Department of Physiology,
      Development and Neuroscience, Downing Street, Cambridge CB2 3DY, UK.
FAU - Johnson, Martin H
AU  - Johnson MH
LA  - eng
GR  - 084418/Wellcome Trust/United Kingdom
GR  - 088708/Wellcome Trust/United Kingdom
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110124
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
SB  - IM
CIN - Reprod Biomed Online. 2011 May;22(5):410-20. PMID: 21388885
CIN - Reprod Biomed Online. 2011 May;22(5):408-9. PMID: 21393061
MH  - Animals
MH  - Embryo Research/ethics/*history/legislation & jurisprudence
MH  - History, 20th Century
MH  - Humans
MH  - Preimplantation Diagnosis/*history
MH  - United Kingdom
PMC - PMC3101706
EDAT- 2011/03/15 06:00
MHDA- 2015/07/03 06:00
CRDT- 2011/03/15 06:00
PHST- 2010/10/14 00:00 [received]
PHST- 2010/12/07 00:00 [revised]
PHST- 2011/01/05 00:00 [accepted]
PHST- 2011/03/15 06:00 [entrez]
PHST- 2011/03/15 06:00 [pubmed]
PHST- 2015/07/03 06:00 [medline]
AID - S1472-6483(11)00024-1 [pii]
AID - 10.1016/j.rbmo.2011.01.008 [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2011 May;22(5):457-71. doi: 10.1016/j.rbmo.2011.01.008.
      Epub 2011 Jan 24.


PMID- 21397111
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20110314
IS  - 1545-7206 (Electronic)
IS  - 0033-3182 (Linking)
VI  - 52
IP  - 2
DP  - 2011 Mar-Apr
TI  - To treat or not to treat: psychosis, palliative care, and ethics at the
      end-of-life: a case analysis.
PG  - 178-84
LID - 10.1016/j.psym.2010.12.003 [doi]
FAU - Geppert, Cynthia M A
AU  - Geppert CM
AD  - New Mexico Veteran's Affairs Health Care System, Department of Psychiatry and
      Ethics Education, 1501 San Pedro Dr. SE, Albuquerque, NM 87108, USA.
      ethivdoc@comcast.net
FAU - Rabjohn, Patrick
AU  - Rabjohn P
FAU - Vlaskovits, Joseph
AU  - Vlaskovits J
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Psychosomatics
JT  - Psychosomatics
JID - 0376506
SB  - IM
MH  - *Ethics, Medical
MH  - Fatal Outcome
MH  - Humans
MH  - Laryngeal Neoplasms/*psychology/*therapy
MH  - Male
MH  - Middle Aged
MH  - Palliative Care/*ethics
MH  - Psychotic Disorders/drug therapy/psychology
MH  - Terminal Care/*ethics
EDAT- 2011/03/15 06:00
MHDA- 2011/07/27 06:00
CRDT- 2011/03/15 06:00
PHST- 2009/10/06 00:00 [received]
PHST- 2010/02/19 00:00 [revised]
PHST- 2010/02/22 00:00 [accepted]
PHST- 2011/03/15 06:00 [entrez]
PHST- 2011/03/15 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
AID - S0033-3182(10)00026-5 [pii]
AID - 10.1016/j.psym.2010.12.003 [doi]
PST - ppublish
SO  - Psychosomatics. 2011 Mar-Apr;52(2):178-84. doi: 10.1016/j.psym.2010.12.003.


PMID- 21396685
OWN - NLM
STAT- MEDLINE
DCOM- 20111102
LR  - 20121115
IS  - 1879-2472 (Electronic)
IS  - 0049-3848 (Linking)
VI  - 128
IP  - 1
DP  - 2011 Jul
TI  - Induced human pluripotent stem cells and advanced therapies: future perspectives 
      for the treatment of haemophilia?
PG  - 8-13
LID - 10.1016/j.thromres.2011.01.010 [doi]
AB  - Human induced pluripotent stem cells (iPSCs) have revolutionized the stem cell
      field. These iPSCs from somatic cells have been reprogrammed with the
      introduction of transcription factors and are capable to differentiate into cells
      from all three germ layers. These strategies require retrovirus transduction or
      transfection of plasmid vectors strategy without viral transduction. Another
      promising strategy is based on direct delivery of the reprogramming proteins,
      addition of signal transduction inhibitors and chemical promoter cell survival.
      The main advantages of iPSCs cells are that they have not included in the debate 
      over the ethics of embryonic stem cell. Current therapy of haemophilia is based
      on factor VIII (FVIII) or factor IX (FIX) replacement therapy including
      prophylactic or demand protocols of fixed-dose, and as future alternative, gene
      and cell therapy. Gene therapy can be made by using viral vectors, mainly
      lentiviral (LVV) and adeno-associated viruses (AAV) in adult stem cells and
      autologous fibroblasts, platelets or haematopoietic stem cells, and transfer
      using non-viral vectors (NVV). Cell therapy for haemophilia is based, mainly, in 
      transplantation of healthy cells to replace the deficient function, for example, 
      the transplantation of liver sinusoidal endothelial cells or endothelial
      progenitor cells derived from iPSCs. Recently, as first time in haemophilia,
      endothelial progenitor cells derived from iPSCs cells express FVIII protein
      effectively, engraft within the hepatic parenchyma, and functionally integrate to
      provide the therapeutic benefit for a phenotypic correction in haemophilia.
      Advanced therapies, gene and cell therapy and tissue engineering or iPSCs
      technology, can provide a potential clinical application in the treatment of
      haemophilia and other monogenic disorders. Because to date there are not relevant
      results for phenotypic correction in haemophilia, iPSCs technology could
      represent a potential alternative based on cellular therapy.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Liras, A
AU  - Liras A
AD  - Department of Physiology, Biology School, Universidad Complutense of Madrid,
      Spain. aliras@hotmail.com
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110310
PL  - United States
TA  - Thromb Res
JT  - Thrombosis research
JID - 0326377
SB  - IM
MH  - Adult
MH  - Animals
MH  - Cell Differentiation/physiology
MH  - Genetic Therapy/methods
MH  - Hemophilia A/genetics/surgery/*therapy
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*physiology/*transplantation
EDAT- 2011/03/15 06:00
MHDA- 2011/11/04 06:00
CRDT- 2011/03/15 06:00
PHST- 2010/09/23 00:00 [received]
PHST- 2011/01/25 00:00 [revised]
PHST- 2011/01/28 00:00 [accepted]
PHST- 2011/03/15 06:00 [entrez]
PHST- 2011/03/15 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
AID - S0049-3848(11)00060-0 [pii]
AID - 10.1016/j.thromres.2011.01.010 [doi]
PST - ppublish
SO  - Thromb Res. 2011 Jul;128(1):8-13. doi: 10.1016/j.thromres.2011.01.010. Epub 2011 
      Mar 10.


PMID- 21396235
OWN - NLM
STAT- MEDLINE
DCOM- 20110623
LR  - 20220317
IS  - 1555-3892 (Electronic)
IS  - 0963-6897 (Linking)
VI  - 20
IP  - 1
DP  - 2011
TI  - Mesenchymal stem cells.
PG  - 5-14
LID - 10.3727/096368910X [doi]
AB  - Stem cells have two features: the ability to differentiate along different
      lineages and the ability of self-renewal. Two major types of stem cells have been
      described, namely, embryonic stem cells and adult stem cells. Embryonic stem
      cells (ESC) are obtained from the inner cell mass of the blastocyst and are
      associated with tumorigenesis, and the use of human ESCs involves ethical and
      legal considerations. The use of adult mesenchymal stem cells is less problematic
      with regard to these issues. Mesenchymal stem cells (MSCs) are stromal cells that
      have the ability to self-renew and also exhibit multilineage differentiation.
      MSCs can be isolated from a variety of tissues, such as umbilical cord,
      endometrial polyps, menses blood, bone marrow, adipose tissue, etc. This is
      because the ease of harvest and quantity obtained make these sources most
      practical for experimental and possible clinical applications. Recently, MSCs
      have been found in new sources, such as menstrual blood and endometrium. There
      are likely more sources of MSCs waiting to be discovered, and MSCs may be a good 
      candidate for future experimental or clinical applications. One of the major
      challenges is to elucidate the mechanisms of differentiation, mobilization, and
      homing of MSCs, which are highly complex. The multipotent properties of MSCs make
      them an attractive choice for possible development of clinical applications.
      Future studies should explore the role of MSCs in differentiation,
      transplantation, and immune response in various diseases.
FAU - Ding, Dah-Ching
AU  - Ding DC
AD  - Department of Obstetrics and Gynecology, Buddhist Tzu Chi General Hospital, Tzu
      Chi University, Hualien, Taiwan, ROC.
FAU - Shyu, Woei-Cherng
AU  - Shyu WC
FAU - Lin, Shinn-Zong
AU  - Lin SZ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Cell Transplant
JT  - Cell transplantation
JID - 9208854
SB  - IM
MH  - Cell Differentiation
MH  - Endometrium/cytology
MH  - Fallopian Tubes/cytology
MH  - Female
MH  - Fetal Blood/cytology
MH  - Humans
MH  - Ligaments, Articular/cytology
MH  - Mesenchymal Stem Cell Transplantation
MH  - Mesenchymal Stem Cells/*cytology/immunology/metabolism
EDAT- 2011/03/15 06:00
MHDA- 2011/06/24 06:00
CRDT- 2011/03/15 06:00
PHST- 2011/03/15 06:00 [entrez]
PHST- 2011/03/15 06:00 [pubmed]
PHST- 2011/06/24 06:00 [medline]
AID - 10.3727/096368910X [doi]
PST - ppublish
SO  - Cell Transplant. 2011;20(1):5-14. doi: 10.3727/096368910X.


PMID- 21396152
OWN - NLM
STAT- MEDLINE
DCOM- 20120905
LR  - 20211020
IS  - 1469-5111 (Electronic)
IS  - 1461-1457 (Linking)
VI  - 15
IP  - 4
DP  - 2012 May
TI  - The ethics of elective psychopharmacology.
PG  - 559-71
LID - 10.1017/S146114571100037X [doi]
AB  - Pharmacological cognitive enhancers (PCEs) are used to improve cognitive
      functions, such as attention, learning, memory and planning in patients with
      impairments in cognition resulting from traumatic brain injury (TBI) or from
      neuropsychiatric disorders such as Alzheimer's disease (AD), mild cognitive
      impairment, schizophrenia, and attention deficit hyperactivity disorder (ADHD).
      Moreover, PCEs have been shown to improve cognition in healthy volunteers with no
      psychiatric disorders. This article describes the rationale behind the need for
      their use in neuropsychiatric patients and illustrates how PCEs can ameliorate
      cognitive impairments, improve quality of life and wellbeing, and therefore
      reduce the economic burden associated with these disorders. We also describe
      evidence that PCEs are being used as cognitive enhancers by healthy people.
      Crucially, as the lifestyle use of these drugs becomes very popular in the
      healthy population, a final aim is to present an overview of the current and
      future neuroethical considerations of enhancing the healthy brain. As information
      regarding their actual use, benefits and harms in various healthy populations is 
      currently lacking, we propose research that aims to obtain relevant empirical
      data, monitor the short- and long-term effectiveness and side-effects, and
      initiate accurate surveys to determine current patterns and quantity of usage of 
      PCE drugs by healthy people. Furthermore, in order to instigate a dialogue
      between neuroethics and neuropsychopharmacology, we urge scientists to explore
      and communicate the social and ethical implications of their research to the
      public. Finally, we discuss and highlight other means of enhancing cognition in
      both patients and healthy adults, including education and physical exercise.
FAU - Mohamed, Ahmed D
AU  - Mohamed AD
AD  - Department of Psychiatry, University of Cambridge School of Clinical Medicine,
      Addenbrooke's Hospital, Cambridge, UK. adm67@cam.ac.uk
FAU - Sahakian, Barbara J
AU  - Sahakian BJ
LA  - eng
GR  - 086041/Wellcome Trust/United Kingdom
GR  - G0001354/MRC_/Medical Research Council/United Kingdom
GR  - 019407/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110314
PL  - England
TA  - Int J Neuropsychopharmacol
JT  - The international journal of neuropsychopharmacology
JID - 9815893
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Neurotransmitter Agents)
SB  - IM
MH  - Central Nervous System Stimulants/*pharmacology
MH  - Cognition/*drug effects/ethics
MH  - *Ethics
MH  - Humans
MH  - Life Style
MH  - Neurotransmitter Agents/metabolism
MH  - Pharmacogenetics/ethics
MH  - Psychopharmacology/*ethics
PMC - PMC3325502
EDAT- 2011/03/15 06:00
MHDA- 2012/09/06 06:00
CRDT- 2011/03/15 06:00
PHST- 2011/03/15 06:00 [entrez]
PHST- 2011/03/15 06:00 [pubmed]
PHST- 2012/09/06 06:00 [medline]
AID - S146114571100037X [pii]
AID - 10.1017/S146114571100037X [doi]
PST - ppublish
SO  - Int J Neuropsychopharmacol. 2012 May;15(4):559-71. doi:
      10.1017/S146114571100037X. Epub 2011 Mar 14.


PMID- 21392915
OWN - NLM
STAT- MEDLINE
DCOM- 20120822
LR  - 20211020
IS  - 1872-7727 (Electronic)
IS  - 0720-048X (Linking)
VI  - 81
IP  - 5
DP  - 2012 May
TI  - Perfusion CT assessment of the colon and rectum: feasibility of quantification of
      bowel wall perfusion and vascularization.
PG  - 821-4
LID - 10.1016/j.ejrad.2011.02.033 [doi]
AB  - The aim was to determine the feasibility of vascular quantification of the bowel 
      wall for different anatomical segments of the colorectum. Following institutional
      ethical approval and informed consent, 39 patients with colorectal cancer
      underwent perfusion CT. Blood flow (BF), blood volume (BV), mean transit time
      (MTT), and permeability surface area product (PS) were assessed for different
      segments of the colorectum: ascending, transverse, descending colon, sigmoid, or 
      rectum, that were distant from the tumor, and which were proven normal on
      contemporary colonoscopy, and subsequent imaging and clinical follow up. Mean
      (SD) for BF, BV, MTT and PS for the different anatomical colorectal segments were
      obtained and compared using a pooled t-test. Significance was at 5%. Assessment
      was not possible in 9 of 39 (23%) patients as the bowel wall was </= 5 mm
      precluding quantitative analysis. Forty-four segments were evaluated in the
      remaining 30 patients. Mean BF was higher in the proximal than distal colon: 24.0
      versus 17.8 mL/min/100g tissue; p=0.009; BV, MTT and PS were not significantly
      different; BV: 3.46 versus 3.15 mL/100g tissue, p=0.45; MTT: 15.1 versus 18.3s;
      p=0.10; PS: 6.84 versus 8.97 mL/min/100 tissue, p=0.13, respectively. In
      conclusion, assessment of bowel wall perfusion may fail in 23% of patients. The
      colorectum demonstrates segmental differences in perfusion.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Khan, Sairah
AU  - Khan S
AD  - Paul Strickland Scanner Centre, Mount Vernon Hospital, Rickmansworth Road,
      Northwood, Middlesex, HA6 2RN, United Kingdom. sairah.khan@imperial.ac.uk
FAU - Goh, Vicky
AU  - Goh V
FAU - Tam, Emily
AU  - Tam E
FAU - Wellsted, David
AU  - Wellsted D
FAU - Halligan, Steve
AU  - Halligan S
LA  - eng
GR  - 09/22/49/DH_/Department of Health/United Kingdom
GR  - PB-PG-0110-21073/DH_/Department of Health/United Kingdom
GR  - PB-PG-0909-19044/DH_/Department of Health/United Kingdom
PT  - Journal Article
DEP - 20110309
PL  - Ireland
TA  - Eur J Radiol
JT  - European journal of radiology
JID - 8106411
SB  - IM
MH  - Aged
MH  - Blood Flow Velocity
MH  - Colon/blood supply/*diagnostic imaging/*physiology
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Perfusion Imaging/*methods
MH  - Rectum/blood supply/*diagnostic imaging/*physiology
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2011/03/12 06:00
MHDA- 2012/08/23 06:00
CRDT- 2011/03/12 06:00
PHST- 2010/09/28 00:00 [received]
PHST- 2011/02/05 00:00 [revised]
PHST- 2011/02/07 00:00 [accepted]
PHST- 2011/03/12 06:00 [entrez]
PHST- 2011/03/12 06:00 [pubmed]
PHST- 2012/08/23 06:00 [medline]
AID - S0720-048X(11)00218-X [pii]
AID - 10.1016/j.ejrad.2011.02.033 [doi]
PST - ppublish
SO  - Eur J Radiol. 2012 May;81(5):821-4. doi: 10.1016/j.ejrad.2011.02.033. Epub 2011
      Mar 9.


PMID- 21392699
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20110311
IS  - 1097-6752 (Electronic)
IS  - 0889-5406 (Linking)
VI  - 139
IP  - 3
DP  - 2011 Mar
TI  - Litigation, legislation, and ethics. When patients lie to their doctors.
PG  - 417-8
LID - 10.1016/j.ajodo.2010.09.004 [doi]
FAU - Jerrold, Laurance
AU  - Jerrold L
AD  - Orthodontic Consulting Group, LLC., Jacksonville, FL, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Orthod Dentofacial Orthop
JT  - American journal of orthodontics and dentofacial orthopedics : official
      publication of the American Association of Orthodontists, its constituent
      societies, and the American Board of Orthodontics
JID - 8610224
SB  - IM
MH  - *Deception
MH  - Diagnostic Errors/legislation & jurisprudence
MH  - Humans
MH  - Malpractice/*legislation & jurisprudence
MH  - *Medical History Taking
MH  - *Professional-Patient Relations
MH  - Risk Management/legislation & jurisprudence
MH  - United States
EDAT- 2011/03/12 06:00
MHDA- 2011/06/03 06:00
CRDT- 2011/03/12 06:00
PHST- 2010/09/01 00:00 [received]
PHST- 2010/09/01 00:00 [revised]
PHST- 2010/09/01 00:00 [accepted]
PHST- 2011/03/12 06:00 [entrez]
PHST- 2011/03/12 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
AID - S0889-5406(10)00765-1 [pii]
AID - 10.1016/j.ajodo.2010.09.004 [doi]
PST - ppublish
SO  - Am J Orthod Dentofacial Orthop. 2011 Mar;139(3):417-8. doi:
      10.1016/j.ajodo.2010.09.004.


PMID- 21391078
OWN - NLM
STAT- MEDLINE
DCOM- 20110711
LR  - 20121101
IS  - 1552-4264 (Electronic)
IS  - 1552-4264 (Linking)
VI  - 7
IP  - 1
DP  - 2011
TI  - Key role of social work in effective communication and conflict resolution
      process: Medical Orders for Life-Sustaining Treatment (MOLST) Program in New York
      and shared medical decision making at the end of life.
PG  - 56-82
LID - 10.1080/15524256.2011.548047 [doi]
AB  - In this article, the authors review the development of the Medical Orders for
      Life-Sustaining Treatment (MOLST) Program and recent landmark legislation in New 
      York State in the context of advance care planning and shared medical decision
      making at the end of life. Social workers are central health care professionals
      in working with patients, families, practitioners, health care agents, and
      surrogates in the health systems and in the communication and conflict resolution
      process that is integral to health care decision making. The critical importance 
      of ethics and end-of-life training and education for social workers is also
      addressed. Data from a pilot study evaluating interdisciplinary ethics training
      on legal and ethical content in communication and conflict resolution skills in
      health care decision making are reported. Recommendations are made for research
      on education and training of social workers, and investigation of the role and
      influence of systems in shaping social work involvement in end-of-life and
      palliative care.
FAU - Bomba, Patricia A
AU  - Bomba PA
AD  - University of Rochester Medical Center, Rochester, NY, USA.
      Patricia.Bomba@lifethc.com
FAU - Morrissey, Mary Beth
AU  - Morrissey MB
FAU - Leven, David C
AU  - Leven DC
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Soc Work End Life Palliat Care
JT  - Journal of social work in end-of-life & palliative care
JID - 101235219
SB  - IM
MH  - Advance Care Planning/legislation & jurisprudence/*organization & administration
MH  - Communication
MH  - Decision Making
MH  - Family/psychology
MH  - Humans
MH  - Life Support Care
MH  - *Negotiating
MH  - New York
MH  - Palliative Care/economics/*organization & administration
MH  - Patient Preference
MH  - Social Work/*organization & administration
MH  - Terminal Care/economics/*organization & administration
MH  - Third-Party Consent/legislation & jurisprudence
MH  - Withholding Treatment/ethics/legislation & jurisprudence
EDAT- 2011/03/11 06:00
MHDA- 2011/07/12 06:00
CRDT- 2011/03/11 06:00
PHST- 2011/03/11 06:00 [entrez]
PHST- 2011/03/11 06:00 [pubmed]
PHST- 2011/07/12 06:00 [medline]
AID - 934189636 [pii]
AID - 10.1080/15524256.2011.548047 [doi]
PST - ppublish
SO  - J Soc Work End Life Palliat Care. 2011;7(1):56-82. doi:
      10.1080/15524256.2011.548047.


PMID- 21391076
OWN - NLM
STAT- MEDLINE
DCOM- 20110711
LR  - 20121101
IS  - 1552-4264 (Electronic)
IS  - 1552-4264 (Linking)
VI  - 7
IP  - 1
DP  - 2011
TI  - Phenomenology of pain and suffering at the end of life: a humanistic perspective 
      in gerontological health and social work.
PG  - 14-38
LID - 10.1080/15524256.2011.548045 [doi]
AB  - In this article, the author examines the phenomenology of pain and suffering and 
      the fundamentally social nature of living with serious illness for older adults
      at life's end. She focuses on three concerns in gerontological health and social 
      work: developing a phenomenological account of lived experiences of pain and
      suffering; articulating a humanistic phenomenological perspective on the
      axiological and ethical dimensions of pain and suffering; and exploring a
      phenomenological approach to a more humanistic, person-centered social work
      practice with older adults in end-of-life and palliative care. The contribution
      that the author makes through this article is in elaborating a humanistic
      framework for understanding agency, obligation, and ethical choice in end-of-life
      decision making.
FAU - Morrissey, Mary Beth
AU  - Morrissey MB
AD  - Fordham Ravazzin Center on Aging, West Harrison, NY, USA. mamorrissey@fordham.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Soc Work End Life Palliat Care
JT  - Journal of social work in end-of-life & palliative care
JID - 101235219
SB  - IM
MH  - *Aging
MH  - Decision Making
MH  - Humanism
MH  - Humans
MH  - Interdisciplinary Communication
MH  - Pain/*psychology
MH  - Palliative Care/*organization & administration
MH  - Social Work/*organization & administration
MH  - Terminal Care/*organization & administration
EDAT- 2011/03/11 06:00
MHDA- 2011/07/12 06:00
CRDT- 2011/03/11 06:00
PHST- 2011/03/11 06:00 [entrez]
PHST- 2011/03/11 06:00 [pubmed]
PHST- 2011/07/12 06:00 [medline]
AID - 934189843 [pii]
AID - 10.1080/15524256.2011.548045 [doi]
PST - ppublish
SO  - J Soc Work End Life Palliat Care. 2011;7(1):14-38. doi:
      10.1080/15524256.2011.548045.


PMID- 21390963
OWN - NLM
STAT- MEDLINE
DCOM- 20120112
LR  - 20110906
IS  - 1744-1706 (Electronic)
IS  - 1744-1692 (Linking)
VI  - 6
IP  - 7
DP  - 2011
TI  - A critical public-health ethics analysis of Canada's international response to
      HIV.
PG  - 777-93
LID - 10.1080/17441692.2011.553627 [doi]
AB  - As interconnections between health, ideology and politics become increasingly
      acknowledged, gaps in the literature also become visible in terms of analytic
      frameworks to engage these issues and empirical studies to understand the
      complexities. 'Critical public-health ethics' provides such an analytic lens.
      This article presents the results of a critical public-health ethics analysis of 
      the government of Canada's international response to HIV. This qualitative study 
      involved in-depth, semi-structured interviews with 23 experts on Canada's
      international response over time. Descriptive, thematic and theoretical analyses 
      revealed an underlying dilemma between Canada's philanthropic desire to 'do the
      right thing' for the broader public good and Canada's commitment to its own
      economic growth and other forms of self-interest. Related to this tension were
      four conspicuous areas of silence in the data: (1) The relative absence of moral 
      vocabulary for discussing Canada's duty to respond to the global HIV pandemic.
      (2) Scant reference to solutions based on poverty reduction. (3) Little awareness
      about the dominance of neoliberal economic rationality and its impact on HIV. (4)
      Limited understanding of Canada's function within the international economic
      order in terms of its role in poverty creation. Our study has implications for
      Canada and other rich nations through its empirical contribution to the chorus of
      calls challenging the legitimised, institutionalised and normative practice of
      considering the economic growth of wealthy countries as the primary objective of 
      global economic policy.
FAU - Nixon, Stephanie A
AU  - Nixon SA
AD  - Department of Physical Therapy, Dalla Lana School of Public Health, University of
      Toronto, 160-500 University Avenue, Toronto, ON M5G 1V7, Canada.
      stephanie.nixon@utoronto.ca
FAU - Benatar, Solomon R
AU  - Benatar SR
LA  - eng
PT  - Journal Article
DEP - 20110524
PL  - England
TA  - Glob Public Health
JT  - Global public health
JID - 101256323
SB  - IM
MH  - Canada
MH  - Female
MH  - *HIV Infections
MH  - Humans
MH  - *International Cooperation
MH  - Interviews as Topic
MH  - Male
MH  - Public Health/*ethics
EDAT- 2011/03/11 06:00
MHDA- 2012/01/13 06:00
CRDT- 2011/03/11 06:00
PHST- 2011/03/11 06:00 [entrez]
PHST- 2011/03/11 06:00 [pubmed]
PHST- 2012/01/13 06:00 [medline]
AID - 934647113 [pii]
AID - 10.1080/17441692.2011.553627 [doi]
PST - ppublish
SO  - Glob Public Health. 2011;6(7):777-93. doi: 10.1080/17441692.2011.553627. Epub
      2011 May 24.


PMID- 21390874
OWN - NLM
STAT- MEDLINE
DCOM- 20110721
LR  - 20171116
IS  - 1545-5815 (Electronic)
IS  - 0898-9621 (Linking)
VI  - 18
IP  - 2
DP  - 2011 Mar
TI  - The responsible conduct of bioethics research.
PG  - 102-19
LID - 10.1080/08989621.2011.557302 [doi]
AB  - The responsible conduct of research in the biomedical and behavioral sciences has
      received significant attention since the late 1980s. However, very little has
      been written about the responsible conduct of bioethics research. Bioethics is an
      interdisciplinary field and brings together divergent ethical standards and
      practices which may be the source of tension or conflict. This article argues
      that bioethicists should reflect more on ethical issues in the responsible
      conduct of bioethics research through examination of authorship practices and
      peer review. I also outline three possible approaches to promote research
      integrity in bioethics.
FAU - Master, Zubin
AU  - Master Z
AD  - Health Law Institute, Law Centre, University of Alberta, Edmonton, Alberta,
      Canada. zubin@zubsplace.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Account Res
JT  - Accountability in research
JID - 9100813
SB  - IM
MH  - *Authorship
MH  - Biomedical Research/*ethics
MH  - *Ethics, Research
MH  - Humans
MH  - *Manuscripts, Medical as Topic
MH  - Peer Review/*ethics
MH  - *Social Responsibility
EDAT- 2011/03/11 06:00
MHDA- 2011/07/22 06:00
CRDT- 2011/03/11 06:00
PHST- 2011/03/11 06:00 [entrez]
PHST- 2011/03/11 06:00 [pubmed]
PHST- 2011/07/22 06:00 [medline]
AID - 934341631 [pii]
AID - 10.1080/08989621.2011.557302 [doi]
PST - ppublish
SO  - Account Res. 2011 Mar;18(2):102-19. doi: 10.1080/08989621.2011.557302.


PMID- 21390526
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140607
LR  - 20211020
IS  - 0022-5010 (Print)
IS  - 0022-5010 (Linking)
VI  - 44
IP  - 4
DP  - 2011 Winter
TI  - The seven sisters: subgenres of bioi of contemporary life scientists.
PG  - 633-50
LID - 10.1007/s10739-011-9272-x [doi]
AB  - Today, scientific biography is primarily thought of as a way of writing
      contextual history of science. But the genre has other functions as well. This
      article discusses seven kinds of ideal-typical subgenres of scientific biography.
      In addition to its mainstream function as an ancilla historiae, it is also
      frequently used to enrich the understanding of the individual construction of
      scientific knowledge, to promote the public engagement with science, and as a
      substitute for belles-lettres. Currently less acknowledged kinds of scientific
      biography include its use as a medium for public and private, respectively,
      commemoration. Finally, the use of scientific biography as a research (virtue)
      ethical genre, providing examples of 'the good life in science', is emphasized.
FAU - Soderqvist, Thomas
AU  - Soderqvist T
AD  - Medical Museion, University of Copenhagen, Fredericiagade 18, 1310, Copenhagen,
      Denmark, ths@sund.ku.dk.
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - J Hist Biol
JT  - Journal of the history of biology
JID - 0202503
EDAT- 2011/03/11 06:00
MHDA- 2011/03/11 06:01
CRDT- 2011/03/11 06:00
PHST- 2011/03/11 06:00 [entrez]
PHST- 2011/03/11 06:00 [pubmed]
PHST- 2011/03/11 06:01 [medline]
AID - 10.1007/s10739-011-9272-x [doi]
PST - ppublish
SO  - J Hist Biol. 2011 Winter;44(4):633-50. doi: 10.1007/s10739-011-9272-x.


PMID- 21390175
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20220330
IS  - 2093-0569 (Electronic)
IS  - 2005-9159 (Linking)
VI  - 24
IP  - 1
DP  - 2011 Mar
TI  - A Randomised, Placebo-controlled Trial of the Effects of Preoperative Pregabalin 
      on Pain Intensity and Opioid Consumption following Lumbar Discectomy.
PG  - 22-30
LID - 10.3344/kjp.2011.24.1.22 [doi]
AB  - BACKGROUND: Pregabalin has been shown to have analgesic effect in acute pain
      models. The primary objective was to examine the efficacy a single dose of
      pregabalin, would have on morphine consumption following lumbar discectomy.
      METHODS: With ethical approval a randomized, placebo-controlled prospective trial
      was undertaken in 32 patients (ASA I-II, 18-65 years) with radicular low back
      pain for > 3 months undergoing elective lumbar discectomy. Patients received
      either oral pregabalin 300 mg (PG Group) or placebo (C Group) one hour before
      surgery. Pain intensity, the accumulative morphine consumption and adverse
      effects were recorded for 24 hours following surgery. Functional, psychological
      and quantitative sensory testing were also assessed. RESULTS: Fourteen patients
      out of the 32 recruited were randomized to receive pregabalin. Morphine
      consumption was reduced (absolute difference of 42.3%) between groups with medium
      effect size. (Mann-Whitney; U = 52.5, z-score= 2.84, P = 0.004, r = 0.14). This
      was not associated with a significant difference in the incidence of adverse
      effects between the two groups. The median pain intensity (VAS) on movement was
      not significantly different between groups. CONCLUSIONS: A single pre-operative
      dose of pregabalin (300 mg) did not result in a reduction in pain intensity
      compared to placebo in this patient cohort but the significant reduction in
      morphine consumption suggests that a fixed peri-operative dosing regime warrants 
      investigation.
FAU - Hegarty, Dominic A
AU  - Hegarty DA
AD  - Department of Anaesthesia, Intensive Care & Pain Medicine, Cork University
      Hospital, Wilton, Cork, Ireland.
FAU - Shorten, George D
AU  - Shorten GD
LA  - eng
PT  - Journal Article
DEP - 20110225
PL  - Korea (South)
TA  - Korean J Pain
JT  - The Korean journal of pain
JID - 101528125
PMC - PMC3049973
OTO - NOTNLM
OT  - morphine consumption
OT  - post-operative pain
OT  - pregabalin
EDAT- 2011/03/11 06:00
MHDA- 2011/03/11 06:01
CRDT- 2011/03/11 06:00
PHST- 2010/12/07 00:00 [received]
PHST- 2011/01/16 00:00 [revised]
PHST- 2011/01/21 00:00 [accepted]
PHST- 2011/03/11 06:00 [entrez]
PHST- 2011/03/11 06:00 [pubmed]
PHST- 2011/03/11 06:01 [medline]
AID - 10.3344/kjp.2011.24.1.22 [doi]
PST - ppublish
SO  - Korean J Pain. 2011 Mar;24(1):22-30. doi: 10.3344/kjp.2011.24.1.22. Epub 2011 Feb
      25.


PMID- 21390038
OWN - NLM
STAT- MEDLINE
DCOM- 20110920
LR  - 20151119
IS  - 1435-232X (Electronic)
IS  - 1434-5161 (Linking)
VI  - 56
IP  - 5
DP  - 2011 May
TI  - For what am I participating? The need for communication after receiving consent
      from biobanking project participants: experience in Japan.
PG  - 358-63
LID - 10.1038/jhg.2011.19 [doi]
AB  - This paper introduces methods used to communicate with participants in the
      'Biobank Japan Project (BBJP)', which is a disease-focused biobanking project.
      The methods and their implications are discussed in the context of the ethical
      conduct of the biobanking project. Informed consent, which ensures the autonomous
      decisions of participants, is believed to be practically impossible for the
      biobanking project in general. Consequently, the concept of 'trust', which is
      'judgement and action in conditions of less than perfect information', has been
      suggested to compensate for this limitation. As a means to maintain the trust
      participants feel for the project, this paper proposes communication with
      participants after receiving their consent. After describing the limitations of
      informed consent within the BBJP, based on a survey we conducted, we introduce
      our attempts to communicate with participants, discussing their implications as a
      means to compensate for the limitations of informed consent at the biobanking
      project.
FAU - Watanabe, Maiko
AU  - Watanabe M
AD  - Department of Public Policy, Human Genome Centre, The Institute of Medical
      Sciences, The University of Tokyo, Minato-ku, Tokyo, Japan.
FAU - Inoue, Yusuke
AU  - Inoue Y
FAU - Chang, Chiungfang
AU  - Chang C
FAU - Hong, Hyunsoo
AU  - Hong H
FAU - Kobayashi, Izumi
AU  - Kobayashi I
FAU - Suzuki, Satoshi
AU  - Suzuki S
FAU - Muto, Kaori
AU  - Muto K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110310
PL  - England
TA  - J Hum Genet
JT  - Journal of human genetics
JID - 9808008
SB  - IM
CIN - J Hum Genet. 2011 Jun;56(6):405. PMID: 21525876
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biological Specimen Banks/*ethics
MH  - Child
MH  - *Communication
MH  - *Ethics, Research
MH  - Female
MH  - Health Records, Personal/ethics
MH  - Humans
MH  - *Informed Consent
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - *Patient Participation
MH  - Periodicals as Topic
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2011/03/11 06:00
MHDA- 2011/09/21 06:00
CRDT- 2011/03/11 06:00
PHST- 2011/03/11 06:00 [entrez]
PHST- 2011/03/11 06:00 [pubmed]
PHST- 2011/09/21 06:00 [medline]
AID - jhg201119 [pii]
AID - 10.1038/jhg.2011.19 [doi]
PST - ppublish
SO  - J Hum Genet. 2011 May;56(5):358-63. doi: 10.1038/jhg.2011.19. Epub 2011 Mar 10.


PMID- 21389877
OWN - NLM
STAT- MEDLINE
DCOM- 20151117
LR  - 20140417
IS  - 1539-0683 (Electronic)
IS  - 0361-929X (Linking)
VI  - 36
IP  - 3
DP  - 2011 May-Jun
TI  - Ethical considerations for genetic testing, infertility, and balancing
      maternal-fetal needs.
PG  - 162-8; quiz 169-70
LID - 10.1097/NMC.0b013e3182102221 [doi]
AB  - Among the ethical issues confronting maternal-child nurses are questions
      surrounding genetic testing, contraception and sterilization,
      infertility/assisted reproductive technology, and equality in balancing
      maternal-fetal needs. This article explores these issues, reviews the literature 
      currently available, and discusses nursing clinical implications for each as well
      as representative case studies. The types of support needed by childbearing
      families who are facing ethical issues requires emotional and physical support,
      informational support, and advocacy support. The role of the nurse in educating
      women about the ethical implications of their choices cannot be overestimated.
      When women have been educated about the implications of their decisions and are
      therefore empowered to make informed decisions about their lives and their
      pregnancies, clinical nurses who practice ethically respect those decisions and
      support the women in their choices.
FAU - Callister, Lynn Clark
AU  - Callister LC
AD  - Lynn Clark Callister is a Professor Emerita at Brigham Young University College
      of Nursing. She can be reached via e-mail at Lynn_callister@byu.edu.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - MCN Am J Matern Child Nurs
JT  - MCN. The American journal of maternal child nursing
JID - 7605941
SB  - IM
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Decision Making/*ethics
MH  - Education, Nursing, Continuing
MH  - *Ethics, Nursing
MH  - Female
MH  - Genetic Testing/*ethics
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Infertility/*nursing
MH  - Male
MH  - Maternal-Child Nursing/*ethics
MH  - Neonatal Nursing/*ethics
MH  - Nurse's Role
MH  - Nurse-Patient Relations
MH  - Pregnancy
MH  - Reproductive Techniques, Assisted/*ethics
EDAT- 2011/03/11 06:00
MHDA- 2015/11/18 06:00
CRDT- 2011/03/11 06:00
PHST- 2011/03/11 06:00 [entrez]
PHST- 2011/03/11 06:00 [pubmed]
PHST- 2015/11/18 06:00 [medline]
AID - 10.1097/NMC.0b013e3182102221 [doi]
PST - ppublish
SO  - MCN Am J Matern Child Nurs. 2011 May-Jun;36(3):162-8; quiz 169-70. doi:
      10.1097/NMC.0b013e3182102221.


PMID- 21389876
OWN - NLM
STAT- MEDLINE
DCOM- 20151117
LR  - 20140417
IS  - 1539-0683 (Electronic)
IS  - 0361-929X (Linking)
VI  - 36
IP  - 3
DP  - 2011 May-Jun
TI  - Ethics of infant relinquishment, cultural considerations, and obstetric
      conveniences.
PG  - 171-7; quiz 178-9
LID - 10.1097/NMC.0b013e3182102236 [doi]
AB  - Ethical issues relating to infant relinquishment, caring for culturally diverse
      women, the importance of shared power between women and their caregivers, and the
      provision of evidence-based practice versus reliance on obstetric conveniences
      are addressed in this article. Respectful care of women relinquishing their
      infants including use of appropriate language demonstrates moral and ethical
      nursing practice; providing cultural competent care of multilinguistic,
      multicultural, and multiethnic childbearing women and their families is an
      ethical imperative. Nurses practicing ethically will foster adoption of best
      practices on perinatal and neonatal units, and generate a clearly articulated
      vision of woman and family centered organizational culture. In ethical terms,
      this demonstrates respect for others as well as beneficence. Promoting the use of
      ethical nursing practice and evidence-based practice requires that nurses
      identify change agents, those who are champions and facilitators of
      evidence-based practice, and then reward such innovators and make sure that
      clinical guidelines be developed based on best practices.
FAU - Callister, Lynn Clark
AU  - Callister LC
AD  - Lynn Clark Callister is a Professor Emerita at Brigham Young University College
      of Nursing. She can be reached via e-mail at Lynn_callister@byu.edu.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - MCN Am J Matern Child Nurs
JT  - MCN. The American journal of maternal child nursing
JID - 7605941
SB  - IM
MH  - *Adoption
MH  - Adult
MH  - *Cultural Diversity
MH  - Culturally Competent Care/*ethics
MH  - Education, Nursing, Continuing
MH  - *Ethics, Nursing
MH  - Evidence-Based Nursing/*ethics
MH  - Female
MH  - Humans
MH  - Male
MH  - Neonatal Nursing/*ethics
MH  - Nurse's Role
MH  - Nurse-Patient Relations
MH  - Obstetric Nursing/*ethics
MH  - Pregnancy
EDAT- 2011/03/11 06:00
MHDA- 2015/11/18 06:00
CRDT- 2011/03/11 06:00
PHST- 2011/03/11 06:00 [entrez]
PHST- 2011/03/11 06:00 [pubmed]
PHST- 2015/11/18 06:00 [medline]
AID - 10.1097/NMC.0b013e3182102236 [doi]
PST - ppublish
SO  - MCN Am J Matern Child Nurs. 2011 May-Jun;36(3):171-7; quiz 178-9. doi:
      10.1097/NMC.0b013e3182102236.


PMID- 21389174
OWN - NLM
STAT- MEDLINE
DCOM- 20110725
LR  - 20110310
IS  - 1943-3662 (Electronic)
IS  - 1093-6793 (Linking)
VI  - 39
IP  - 1
DP  - 2011
TI  - Psychotropics without borders: ethics and legal implications of internet-based
      access to psychiatric medications.
PG  - 104-11
AB  - Medical practitioners are revisiting many of the ethics and the legal
      implications surrounding the clinical frameworks within which we operate. In
      today's world, distinguishing between virtual and physical reality continues to
      be increasingly difficult. The physician may be found grappling with the decision
      of whether to continue to treat a patient who may be obtaining psychotropic
      medications through the Internet. This article approaches some of the clinical
      and legal implications and the ethics regarding the availability of prescription 
      psychotropics over the Internet.
FAU - Klein, Carolina A
AU  - Klein CA
AD  - Saint Elizabeths Hospital, Department of Mental Health, Washington, DC, USA.
      carolina.klein@gmail.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Acad Psychiatry Law
JT  - The journal of the American Academy of Psychiatry and the Law
JID - 9708963
RN  - 0 (Psychotropic Drugs)
SB  - IM
MH  - Health Services Accessibility/*ethics
MH  - Humans
MH  - *Internet
MH  - Psychotropic Drugs/*supply & distribution/therapeutic use
EDAT- 2011/03/11 06:00
MHDA- 2011/07/26 06:00
CRDT- 2011/03/11 06:00
PHST- 2011/03/11 06:00 [entrez]
PHST- 2011/03/11 06:00 [pubmed]
PHST- 2011/07/26 06:00 [medline]
AID - 39/1/104 [pii]
PST - ppublish
SO  - J Am Acad Psychiatry Law. 2011;39(1):104-11.


PMID- 21389173
OWN - NLM
STAT- MEDLINE
DCOM- 20110725
LR  - 20151119
IS  - 1943-3662 (Electronic)
IS  - 1093-6793 (Linking)
VI  - 39
IP  - 1
DP  - 2011
TI  - Treatment of sex offenders in Israeli prison settings.
PG  - 100-3
AB  - The number of incarcerated sex offenders in the Israeli prison system has
      steadily increased during the past decade. While treatment of sex offenders is
      complex, treatment of those in prison seems to be more challenging. This
      publication presents major considerations and dilemmas, clinical as well as
      ethics-related, derived from the experience of the psychiatric division in the
      Israeli prison service in treating sex offenders in this special setting. The
      psychiatrist treating the incarcerated offender must always maintain a sensitive 
      balance between the needs and wishes of his patient and the potential threat to
      society stemming from recidivism.
FAU - Birger, Moshe
AU  - Birger M
AD  - Forensic Psychiatric Division of the Israeli Prison Service (IPS), Beer-Yaacov
      Mental Health Center affiliated with the Sackler School of Medicine, Tel Aviv
      University, Tel Aviv, Israel.
FAU - Bergman-Levy, Tal
AU  - Bergman-Levy T
FAU - Asman, Oren
AU  - Asman O
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Acad Psychiatry Law
JT  - The journal of the American Academy of Psychiatry and the Law
JID - 9708963
SB  - IM
MH  - Humans
MH  - Israel
MH  - Paraphilic Disorders/therapy
MH  - Prisoners/*psychology
MH  - Prisons
MH  - Psychopharmacology/ethics
MH  - Sex Offenses/*psychology
EDAT- 2011/03/11 06:00
MHDA- 2011/07/26 06:00
CRDT- 2011/03/11 06:00
PHST- 2011/03/11 06:00 [entrez]
PHST- 2011/03/11 06:00 [pubmed]
PHST- 2011/07/26 06:00 [medline]
AID - 39/1/100 [pii]
PST - ppublish
SO  - J Am Acad Psychiatry Law. 2011;39(1):100-3.


PMID- 21388538
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20220408
IS  - 1472-684X (Electronic)
IS  - 1472-684X (Linking)
VI  - 10
DP  - 2011 Mar 9
TI  - End of life care in sub-Saharan Africa: a systematic review of the qualitative
      literature.
PG  - 6
LID - 10.1186/1472-684X-10-6 [doi]
AB  - BACKGROUND: End of life (EoL) care in sub-Saharan Africa still lacks the sound
      evidence-base needed for the development of effective, appropriate service
      provision. It is essential to make evidence from all types of research available 
      alongside clinical and health service data, to ensure that EoL care is ethical
      and culturally appropriate. This article aims to synthesize qualitative research 
      on EoL care in sub-Saharan Africa to inform policy, practice and further
      research. It seeks to identify areas of existing research; describe findings
      specifically relevant to the African context; and, identify areas lacking
      evidence. METHODS: Relevant literature was identified through eight electronic
      databases: AMED, British Nursing Index & Archive, CINAHL, EMBASE, IBSS, MEDLINE, 
      PsycINFO, and the Social Sciences Citation Index; and hand searches. Inclusion
      criteria were: published qualitative or mixed-method studies in sub-Saharan
      Africa, about EoL care. Study quality was assessed using a standard grading
      scale. Relevant data including findings and practice recommendations were
      extracted and compared in tabular format. RESULTS: Of the 407 articles initially 
      identified, 51 were included in the qualitative synthesis. Nineteen came from
      South Africa and the majority (38) focused on HIV/AIDS. Nine dealt with multiple 
      or unspecified conditions and four were about cancer. Study respondents included 
      health professionals, informal carers, patients, community members and bereaved
      relatives. Informal carers were typically women, the elderly and children,
      providing total care in the home, and lacking support from professionals or the
      extended family. Twenty studies focused on home-based care, describing how
      programmes function in practice and what is needed to make them effective.
      Patients and carers were reported to prefer institutional care but this needs to 
      be understood in context. Studies focusing on culture discussed good and bad
      death, culture-specific approaches to symptoms and illness, and the bereavement
      process. CONCLUSIONS: The data support or complement the findings from
      quantitative research. The review prompts a reconsideration of the assumption
      that in Africa the extended family care for the sick, and that people prefer
      home-based care. The review identifies areas relevant for a research agenda on
      socio-cultural issues at the EoL in sub-Saharan Africa.
FAU - Gysels, Marjolein
AU  - Gysels M
AD  - Barcelona Centre for International Health Research (CRESIB, Hospital
      Clinic-Universitat de Barcelona), C/Rossello 132 SA 1 feminine, Barcelona 08036, 
      Spain. Robert.pool@cresib.cat.
FAU - Pell, Christopher
AU  - Pell C
FAU - Straus, Lianne
AU  - Straus L
FAU - Pool, Robert
AU  - Pool R
LA  - eng
PT  - Journal Article
DEP - 20110309
PL  - England
TA  - BMC Palliat Care
JT  - BMC palliative care
JID - 101088685
PMC - PMC3070681
EDAT- 2011/03/11 06:00
MHDA- 2011/03/11 06:01
CRDT- 2011/03/11 06:00
PHST- 2010/10/14 00:00 [received]
PHST- 2011/03/09 00:00 [accepted]
PHST- 2011/03/11 06:00 [entrez]
PHST- 2011/03/11 06:00 [pubmed]
PHST- 2011/03/11 06:01 [medline]
AID - 1472-684X-10-6 [pii]
AID - 10.1186/1472-684X-10-6 [doi]
PST - epublish
SO  - BMC Palliat Care. 2011 Mar 9;10:6. doi: 10.1186/1472-684X-10-6.


PMID- 21388330
OWN - NLM
STAT- MEDLINE
DCOM- 20110322
LR  - 20180510
IS  - 1533-4406 (Electronic)
IS  - 0028-4793 (Linking)
VI  - 364
IP  - 10
DP  - 2011 Mar 10
TI  - Up in the air--suspending ethical medical practice.
PG  - 980; author reply 980
LID - 10.1056/NEJMc1100731 [doi]
FAU - Sventek, Jeffrey
AU  - Sventek J
LA  - eng
PT  - Letter
PT  - Comment
PL  - United States
TA  - N Engl J Med
JT  - The New England journal of medicine
JID - 0255562
SB  - IM
CON - N Engl J Med. 2010 Nov 18;363(21):1988-9. PMID: 21083383
MH  - Aerospace Medicine/*ethics
MH  - Aviation/ethics
MH  - Cardiopulmonary Resuscitation/*ethics
MH  - Ethics, Institutional
MH  - Ethics, Medical
MH  - Heart Arrest/therapy
MH  - Humans
MH  - Medical Futility/ethics
EDAT- 2011/03/11 06:00
MHDA- 2011/03/23 06:00
CRDT- 2011/03/11 06:00
PHST- 2011/03/11 06:00 [entrez]
PHST- 2011/03/11 06:00 [pubmed]
PHST- 2011/03/23 06:00 [medline]
AID - 10.1056/NEJMc1100731 [doi]
AID - 10.1056/NEJMc1100731#SA1 [pii]
PST - ppublish
SO  - N Engl J Med. 2011 Mar 10;364(10):980; author reply 980. doi:
      10.1056/NEJMc1100731.


PMID- 21387973
OWN - NLM
STAT- MEDLINE
DCOM- 20110421
LR  - 20190923
IS  - 1547-1896 (Print)
IS  - 0893-7400 (Linking)
VI  - 24
IP  - 2
DP  - 2011 Feb
TI  - When your mother wants a script: the ethics of treating family members.
PG  - 59-60
FAU - Hill, Helene
AU  - Hill H
FAU - Hill, Matthew
AU  - Hill M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - JAAPA
JT  - JAAPA : official journal of the American Academy of Physician Assistants
JID - 9513102
MH  - *Ethics, Medical
MH  - *Family
MH  - Humans
EDAT- 2011/03/11 06:00
MHDA- 2011/04/22 06:00
CRDT- 2011/03/11 06:00
PHST- 2011/03/11 06:00 [entrez]
PHST- 2011/03/11 06:00 [pubmed]
PHST- 2011/04/22 06:00 [medline]
AID - 10.1097/01720610-201102000-00012 [doi]
PST - ppublish
SO  - JAAPA. 2011 Feb;24(2):59-60. doi: 10.1097/01720610-201102000-00012.


PMID- 21387104
OWN - NLM
STAT- MEDLINE
DCOM- 20110929
LR  - 20211020
IS  - 1433-8726 (Electronic)
IS  - 0724-4983 (Linking)
VI  - 29
IP  - 3
DP  - 2011 Jun
TI  - The role of ethical publishing in promoting the evidence-based practice of
      urology.
PG  - 319-24
LID - 10.1007/s00345-011-0661-8 [doi]
AB  - INTRODUCTION: An evidence-based approach to the practice of urology relies on the
      accumulation of a body of evidence from clinical research. Ethical publishing has
      a major role to play in building confidence in the compiled evidence, which can
      lead to the development of clinical practice guidelines and new treatment
      paradigms. METHODS: The literature on the recent developments in ethical
      publishing was reviewed to highlight how this supported the promotion of the
      evidence-based practice of urology. CONCLUSION: The requirements for complete and
      transparent reporting of results, the honest and full declaration of conflicts of
      interest, and the correct assignment of authorship are essential to build up
      confidence in the evidence-based practice of urology. Increasing the quality of
      the reporting of trials allows the evidence base to be scrutinized and validated.
      Reporting the experience and expertise of authors in compiling, analysing and
      interpreting evidence also helps to develop this trust. A great deal of progress 
      has been made in the recent years, but there is a lot more work to be done.
FAU - Sharrock, Gavin
AU  - Sharrock G
AD  - Wiley-Blackwell, Oxford, UK.
FAU - Graf, Chris
AU  - Graf C
FAU - Fitzpatrick, John M
AU  - Fitzpatrick JM
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110309
PL  - Germany
TA  - World J Urol
JT  - World journal of urology
JID - 8307716
SB  - IM
MH  - Clinical Trials as Topic/ethics
MH  - Conflict of Interest
MH  - Evidence-Based Medicine/*ethics
MH  - Humans
MH  - Reproducibility of Results
MH  - Scientific Misconduct/*trends
MH  - Urology/*ethics
EDAT- 2011/03/10 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/03/10 06:00
PHST- 2010/12/08 00:00 [received]
PHST- 2011/02/11 00:00 [accepted]
PHST- 2011/03/10 06:00 [entrez]
PHST- 2011/03/10 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - 10.1007/s00345-011-0661-8 [doi]
PST - ppublish
SO  - World J Urol. 2011 Jun;29(3):319-24. doi: 10.1007/s00345-011-0661-8. Epub 2011
      Mar 9.


PMID- 21386873
OWN - NLM
STAT- MEDLINE
DCOM- 20111005
LR  - 20211020
IS  - 1476-5438 (Electronic)
IS  - 1018-4813 (Linking)
VI  - 19
IP  - 7
DP  - 2011 Jul
TI  - Children, biobanks and the scope of parental consent.
PG  - 735-9
LID - 10.1038/ejhg.2011.29 [doi]
AB  - The use of stored tissue samples from children for genetic research raises
      specific ethical questions that are not all analogous to those raised when adult 
      participants are concerned. These include issues with regard to consent, as it is
      typically a parent who consents to the use of samples from children. In this
      paper, we discuss the scope of parental consent. This scope has a temporal
      dimension and one related to the content of consent. It is not questioned that
      the temporal scope of parental consent is limited and that young adults have the 
      right to decide on the fate of their samples when they reach the age of maturity.
      With regard to the content of consent, the question remains whether parents are
      allowed to give full broad consent to any possible future research on the samples
      of their children. We argue that they should not be allowed to do so, based on
      two premises. First, it is generally acknowledged that children have a right to
      express their own values and that they should be given the opportunity to develop
      their own autonomy as they grow older. Second, research and science are not
      completely value-free and some types of research may be more sensitive than other
      types. Children should be given the opportunity to express their values also in
      this respect.
FAU - Hens, Kristien
AU  - Hens K
AD  - Centre for Biomedical Ethics and Law, Department of Public Health, Katholieke
      Universiteit Leuven, Leuven, Belgium. Kristien.Hens@med.kuleuven.be
FAU - Cassiman, Jean-Jacques
AU  - Cassiman JJ
FAU - Nys, Herman
AU  - Nys H
FAU - Dierickx, Kris
AU  - Dierickx K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110309
PL  - England
TA  - Eur J Hum Genet
JT  - European journal of human genetics : EJHG
JID - 9302235
SB  - IM
MH  - Biological Specimen Banks/*ethics
MH  - Biomedical Research/ethics
MH  - Child
MH  - Humans
MH  - Parental Consent/*ethics
MH  - Patient Rights/ethics
MH  - Pediatrics
PMC - PMC3137499
EDAT- 2011/03/10 06:00
MHDA- 2011/10/06 06:00
CRDT- 2011/03/10 06:00
PHST- 2011/03/10 06:00 [entrez]
PHST- 2011/03/10 06:00 [pubmed]
PHST- 2011/10/06 06:00 [medline]
AID - ejhg201129 [pii]
AID - 10.1038/ejhg.2011.29 [doi]
PST - ppublish
SO  - Eur J Hum Genet. 2011 Jul;19(7):735-9. doi: 10.1038/ejhg.2011.29. Epub 2011 Mar
      9.


PMID- 21386054
OWN - NLM
STAT- MEDLINE
DCOM- 20110811
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 259
IP  - 3
DP  - 2011 Jun
TI  - Persistent petrosquamosal sinus: high incidence in cases of complete aplasia of
      the semicircular canals.
PG  - 825-33
LID - 10.1148/radiol.11101466 [doi]
AB  - PURPOSE: To determine the frequency and to describe the morphologic
      characteristics and associated skull base anomalies of the petrosquamosal sinus
      (PSS) in cochlear implant candidates with complete aplasia of the semicircular
      canals (SCCs). MATERIALS AND METHODS: Ethics committee approval was obtained.
      Index cases were retrospectively selected from an electronic database in which
      all inner ear malformations observed in patients presenting to a tertiary
      referral center between 1995 and 2010 were collected. Computed tomography (CT)
      data were reviewed by neuroradiologists. Clinical consequences of the
      neuroradiologic findings were analyzed. The Pearson chi(2) test and the
      Mann-Whitney U test were used to determine significant differences between the
      number of PSSs observed in cases of complete aplasia of the SCCs and the number
      observed in cases of other types of inner ear malformations. RESULTS: Inner ear
      malformations were analyzed in 241 patients. Thirty-one patients (13%) with
      bilateral SCC aplasia were identified. Among 31 patients, a uni- or bilateral PSS
      was observed in 25 (81%). In the ears with SCC aplasia, a PSS was observed in 40 
      (65%) of 62. The three cases in which these PSS occupy the largest area correlate
      with bilateral absence of the jugular foramen. In seven of eight ears with a PSS,
      the PSS inhibited surgical exposure or resulted in accidental opening of the PSS 
      during surgery. In all other patients with inner ear malformations, a PSS was
      observed in 39 (9%) of 412 ears only. CONCLUSION: The PSS presents a risk for
      cochlear implant surgery that can be detected by the neuroradiologist in advance.
      Venous CT angiography is advisable in certain cases. The previous assumption that
      a persistent PSS is encountered more frequently in cases of skull base deformity 
      can be affirmed in the special situation of complete aplasia of the SCCs.
CI  - RSNA, 2011
FAU - Giesemann, Anja M
AU  - Giesemann AM
AD  - Department of Diagnostic and Interventional Neuroradiology, Hannover Medical
      School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.
      Giesemann.Anja@mh-hannover.de
FAU - Goetz, G Friedrich
AU  - Goetz GF
FAU - Neuburger, Jurgen
AU  - Neuburger J
FAU - Lenarz, Thomas
AU  - Lenarz T
FAU - Lanfermann, Heinrich
AU  - Lanfermann H
LA  - eng
PT  - Journal Article
DEP - 20110308
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adolescent
MH  - Cerebral Veins/*abnormalities/*diagnostic imaging
MH  - Chi-Square Distribution
MH  - Child
MH  - Child, Preschool
MH  - Cochlear Implantation
MH  - Cranial Sinuses/*abnormalities/*diagnostic imaging
MH  - Female
MH  - Hearing Loss, Sensorineural/*etiology/surgery
MH  - Humans
MH  - Incidence
MH  - Infant
MH  - Male
MH  - Retrospective Studies
MH  - Semicircular Canals/*abnormalities/*diagnostic imaging
MH  - Statistics, Nonparametric
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2011/03/10 06:00
MHDA- 2011/08/13 06:00
CRDT- 2011/03/10 06:00
PHST- 2011/03/10 06:00 [entrez]
PHST- 2011/03/10 06:00 [pubmed]
PHST- 2011/08/13 06:00 [medline]
AID - radiol.11101466 [pii]
AID - 10.1148/radiol.11101466 [doi]
PST - ppublish
SO  - Radiology. 2011 Jun;259(3):825-33. doi: 10.1148/radiol.11101466. Epub 2011 Mar 8.


PMID- 21385429
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20211020
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 12
DP  - 2011 Mar 8
TI  - Ethical issues of unrelated hematopoietic stem cell transplantation in adult
      thalassemia patients.
PG  - 4
LID - 10.1186/1472-6939-12-4 [doi]
AB  - BACKGROUND: Beta thalassemia major is a severe inherited form of hemolytic anemia
      that results from ineffective erythropoiesis. Allogenic hematopoietic stem cell
      transplantation (HSCT) remains the only potentially curative therapy.
      Unfortunately, the subgroup of adult thalassemia patients with hepatomegaly,
      portal fibrosis and a history of irregular iron chelation have an elevated risk
      for transplantation-related mortality that is currently estimated to be about 29 
      percent. DISCUSSION: Thalassemia patients may be faced with a difficult choice:
      they can either continue conventional transfusion and iron chelation therapy or
      accept the high mortality risk of HSCT in the hope of obtaining complete
      recovery.Throughout the decision making process, every effort should be made to
      sustain and enhance autonomous choice. The concept of conscious consent becomes
      particularly important. The patient must be made fully aware of the favourable
      and adverse outcomes of HSCT. Although it is the physician's duty to illustrate
      the possibility of completely restoring health, considerable emphasis should be
      put on the adverse effects of the procedure. The physician also needs to decide
      whether the patient is eligible for HSCT according to the "rule of descending
      order". The patient must be given full details on self-care and fundamental
      lifestyle changes and be fully aware that he/she will be partly responsible for
      the outcome. SUMMARY: Only if all the aforesaid conditions are satisfied can it
      be considered reasonable to propose unrelated HSCT as a potential cure for high
      risk thalassemia patients.
FAU - Caocci, Giovanni
AU  - Caocci G
AD  - Department of Hematology, University of Cagliari, Cagliari, Italy.
FAU - La Nasa, Giorgio
AU  - La Nasa G
FAU - d'Aloja, Ernesto
AU  - d'Aloja E
FAU - Vacca, Adriana
AU  - Vacca A
FAU - Piras, Eugenia
AU  - Piras E
FAU - Pintor, Michela
AU  - Pintor M
FAU - Demontis, Roberto
AU  - Demontis R
FAU - Pisu, Salvatore
AU  - Pisu S
LA  - eng
PT  - Journal Article
DEP - 20110308
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - Adult
MH  - *Beneficence
MH  - Blood Transfusion
MH  - Chelation Therapy
MH  - Choice Behavior/ethics
MH  - Comprehension
MH  - Decision Making/*ethics
MH  - *Graft vs Host Disease/etiology
MH  - Hematopoietic Stem Cell Transplantation/adverse effects/*ethics/*mortality
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Iron
MH  - Judgment
MH  - Life Style
MH  - Motivation
MH  - Patient Education as Topic/ethics
MH  - Patient Selection/*ethics
MH  - Patients/*psychology
MH  - *Personal Autonomy
MH  - Problem Solving
MH  - Quality of Life
MH  - Self Care
MH  - Survival Rate
MH  - Transplantation, Homologous/mortality
MH  - Truth Disclosure/ethics
MH  - beta-Thalassemia/physiopathology/surgery/*therapy
PMC - PMC3063251
EDAT- 2011/03/10 06:00
MHDA- 2011/06/03 06:00
CRDT- 2011/03/10 06:00
PHST- 2010/08/29 00:00 [received]
PHST- 2011/03/08 00:00 [accepted]
PHST- 2011/03/10 06:00 [entrez]
PHST- 2011/03/10 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
AID - 1472-6939-12-4 [pii]
AID - 10.1186/1472-6939-12-4 [doi]
PST - epublish
SO  - BMC Med Ethics. 2011 Mar 8;12:4. doi: 10.1186/1472-6939-12-4.


PMID- 21385246
OWN - NLM
STAT- MEDLINE
DCOM- 20110419
LR  - 20181201
IS  - 0961-7671 (Print)
IS  - 0961-7671 (Linking)
VI  - 19
IP  - 2
DP  - 2011 Apr
TI  - Pharmacist use of social media.
PG  - 140-2
LID - 10.1111/j.2042-7174.2010.00087.x [doi]
AB  - INTRODUCTION: The rapid emergence and exploding usage of social media (also
      called Web 2.0) present pharmacists with new professional, ethical and time
      management challenges. OBJECTIVES: To describe social media use among pharmacists
      in West Virginia, USA. METHODS: A survey was administered during the West
      Virginia Pharmacist Association 102nd Annual Convention held in October 2009. The
      meeting participants were pharmacists practising in the different regions of West
      Virginia. All conference attendees were eligible to participate. RESULTS: The
      survey was completed by all 50 pharmacists in attendance, yielding a response
      rate of 100%. Social media use was found to be common among West Virginia
      pharmacists, with the most frequently used applications including: YouTube (74%),
      Wikipedia (72%), Facebook (50%), and blogs (26%). However, there were some tools 
      that pharmacists barely used such as Bebo, Hi5, Flickr and Friendster. Given the 
      widespread use of Facebook by respondent pharmacists, it is noteworthy that they 
      indicated the main purposes for using it were for chatting, uploading pictures
      and keeping touch with friends rather than for professional and educational
      purposes. DISCUSSION: Presently, pharmacists utilize social media primarily for
      personal purposes. As social media becomes more sophisticated and widely adopted 
      in the healthcare arena, it is probable that pharmacists will also increasingly
      utilize it for professional and educational purposes.
CI  - (c) 2011 The Authors. IJPP (c) 2011 Royal Pharmaceutical Society.
FAU - Alkhateeb, Fadi M
AU  - Alkhateeb FM
AD  - Pharmaceutical and Administrative Sciences, University of Charleston, School of
      Pharmacy, Charleston, WV25705, USA. fadialkhateed@ucwv.edu
FAU - Clauson, Kevin A
AU  - Clauson KA
FAU - Latif, David A
AU  - Latif DA
LA  - eng
PT  - Journal Article
DEP - 20110225
PL  - England
TA  - Int J Pharm Pract
JT  - The International journal of pharmacy practice
JID - 9204243
SB  - IM
MH  - Blogging/*statistics & numerical data
MH  - Communication
MH  - Data Collection
MH  - Humans
MH  - Internet/*statistics & numerical data
MH  - Pharmacists/*statistics & numerical data
MH  - West Virginia
EDAT- 2011/03/10 06:00
MHDA- 2011/04/20 06:00
CRDT- 2011/03/10 06:00
PHST- 2011/03/10 06:00 [entrez]
PHST- 2011/03/10 06:00 [pubmed]
PHST- 2011/04/20 06:00 [medline]
AID - 10.1111/j.2042-7174.2010.00087.x [doi]
PST - ppublish
SO  - Int J Pharm Pract. 2011 Apr;19(2):140-2. doi: 10.1111/j.2042-7174.2010.00087.x.
      Epub 2011 Feb 25.


PMID- 21385084
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20151119
IS  - 1557-7740 (Electronic)
IS  - 1557-7740 (Linking)
VI  - 14
IP  - 5
DP  - 2011 May
TI  - A study investigating the need and impact of pediatric palliative care education 
      on undergraduate medical students in Japan.
PG  - 560-2
LID - 10.1089/jpm.2010.0475 [doi]
AB  - BACKGROUND: Education for medical students is crucial to providing pediatric
      palliative care (PPC). However, few comprehensive curricula of PPC exist in
      Japan. OBJECTIVE: This study aimed to identify and explore the need for education
      of, as well as the impact of that education on, medical students in Japan.
      PARTICIPANTS: The participants were 5th-year medical students (n = 30) who
      studied in our hospital from April 2009 to March 2010. DESIGN/METHODS: The first 
      survey questionnaire was administered before, during, and after a small group
      lecture on PPC, followed by a discussion. The lecture discussed and imparted
      knowledge about general principles of PPC. The second survey questionnaire was
      administered in September 2010 to determine students understanding and attitudes 
      about PPC. RESULTS: In the first survey, none of the students reported any
      exposure to PPC through textbooks or lectures prior to the lecture. In addition, 
      all of them defined PPC as pain management in end-of-life care for children with 
      cancer. The survey also indicated that after the lecture, they understood the
      principles of PPC well. Although they scored low in their understanding of PPC in
      the second survey, their attitude toward the lecture was positive.
      DISCUSSIONS/CONCLUSIONS: This study provided the first opportunity to effectively
      understand the effect of education on PPC in the short term. However, this effect
      was inadequate in the long term. Development of organized medical education
      systems with a primary focus on PPC is urgently needed. Discussion with
      professionals from multiple disciplines with regard to ethical, legal, and
      cultural issues, and social consensus are necessary to develop good educational
      systems.
FAU - Kato, Yoko
AU  - Kato Y
AD  - Department of Pediatrics, Daisan Hospital, Jikei University School of Medicine,
      Minato-ku, Tokyo, Japan. y_kato.ped@jikei.ac.jp
FAU - Akiyama, Masaharu
AU  - Akiyama M
FAU - Itoh, Fumiyuki
AU  - Itoh F
FAU - Ida, Hiroyuki
AU  - Ida H
LA  - eng
PT  - Journal Article
DEP - 20110308
PL  - United States
TA  - J Palliat Med
JT  - Journal of palliative medicine
JID - 9808462
SB  - IM
MH  - Curriculum
MH  - *Education, Medical, Undergraduate
MH  - Humans
MH  - Japan
MH  - *Palliative Care
MH  - *Students, Medical
MH  - Surveys and Questionnaires
EDAT- 2011/03/10 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/03/10 06:00
PHST- 2011/03/10 06:00 [entrez]
PHST- 2011/03/10 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - 10.1089/jpm.2010.0475 [doi]
PST - ppublish
SO  - J Palliat Med. 2011 May;14(5):560-2. doi: 10.1089/jpm.2010.0475. Epub 2011 Mar 8.


PMID- 21384773
OWN - NLM
STAT- MEDLINE
DCOM- 20110407
LR  - 20181201
IS  - 0031-9376 (Print)
IS  - 0031-9376 (Linking)
VI  - 54
IP  - 1
DP  - 2011 Feb
TI  - 2010 Walter C. Randall lecture in biomedical ethics. Scientific integrity:
      positive & negative academic/industry relationships.
PG  - 1, 3-8
FAU - Schwinn, Debra A
AU  - Schwinn DA
AD  - Univ. of Washington, Seattle, USA.
LA  - eng
PT  - Historical Article
PT  - Lecture
PL  - United States
TA  - Physiologist
JT  - The Physiologist
JID - 0401143
SB  - IM
MH  - *Bioethics
MH  - Biomedical Research/ethics
MH  - Conflict of Interest
MH  - History, 21st Century
MH  - Humans
MH  - Industry/*ethics
MH  - Physiology/history
MH  - Science/*ethics
MH  - Societies, Medical
MH  - United States
EDAT- 2011/03/10 06:00
MHDA- 2011/04/08 06:00
CRDT- 2011/03/10 06:00
PHST- 2011/03/10 06:00 [entrez]
PHST- 2011/03/10 06:00 [pubmed]
PHST- 2011/04/08 06:00 [medline]
PST - ppublish
SO  - Physiologist. 2011 Feb;54(1):1, 3-8.


PMID- 21383751
OWN - NLM
STAT- MEDLINE
DCOM- 20110823
LR  - 20110308
IS  - 1573-6741 (Electronic)
IS  - 0002-9548 (Linking)
VI  - 71
IP  - 1
DP  - 2011 Mar
TI  - Toward a psychodynamic approach to bioethics.
PG  - 58-66
LID - 10.1057/ajp.2010.32 [doi]
AB  - Although many first-generation bioethicists were psychiatrists and some received 
      psychoanalytic training, the field of bioethics has developed largely in
      isolation from psychodynamic theory. While much has been written regarding the
      ethics of psychoanalysis, only a few scholars have attempted to explain
      bioethical phenomena in psychodynamic terms. This paper argues for the
      development of a comprehensive theory of "psychodynamic bioethics" that attempts 
      to explain individual and collective attitudes toward bioethical controversy in
      psychodynamic terms.
FAU - Appel, Jacob M
AU  - Appel JM
AD  - The Mount Sinai Hospital, New York, Ny 10027, USA. jacobmappel@gmail.com
LA  - eng
PT  - Journal Article
PL  - England
TA  - Am J Psychoanal
JT  - American journal of psychoanalysis
JID - 0372630
SB  - IM
MH  - *Bioethical Issues
MH  - *Bioethics
MH  - Ethicists
MH  - Humans
MH  - Psychoanalysis/*ethics
EDAT- 2011/03/09 06:00
MHDA- 2011/08/24 06:00
CRDT- 2011/03/09 06:00
PHST- 2011/03/09 06:00 [entrez]
PHST- 2011/03/09 06:00 [pubmed]
PHST- 2011/08/24 06:00 [medline]
AID - ajp201032 [pii]
AID - 10.1057/ajp.2010.32 [doi]
PST - ppublish
SO  - Am J Psychoanal. 2011 Mar;71(1):58-66. doi: 10.1057/ajp.2010.32.


PMID- 21383564
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20151119
IS  - 1530-0358 (Electronic)
IS  - 0012-3706 (Linking)
VI  - 54
IP  - 4
DP  - 2011 Apr
TI  - Prevalence of anal intraepithelial neoplasia in women with genital neoplasia.
PG  - 442-5
LID - 10.1007/DCR.0b013e3182061b34 [doi]
AB  - BACKGROUND: Anal intraepithelial neoplasia is believed to be a precursor of anal 
      cancer, and it appears to be related to high-risk human papillomavirus. Women
      with genital neoplasia have been shown to be at increased risk for anal cancer.
      OBJECTIVE: The aim of this study is to determine the prevalence of anal
      intraepithelial neoplasia in women with genital neoplasia. DESIGN: This is a
      cross-sectional study. SETTING: This study took place at Hospital Nossa Senhora
      da Conceicao, Porto Alegre, Brazil, from May 2008 to April 2010. PATIENTS:
      Included in the study were 106 immunocompetent women with a histopathological
      diagnosis of genital neoplasia and 74 women without gynecologic neoplasia. MAIN
      OUTCOME MEASURE: All women underwent high-resolution anoscopy with biopsies of
      acetowhite areas or abnormal vascular features such as punctation and mosaics for
      histopathological diagnosis of anal intraepithelial neoplasia. RESULTS: : The
      overall prevalence of anal intraepithelial neoplasia was 6.6%. In women with
      genital neoplasia, the prevalence was 10.4% (95% CI, 5.6%-17.3%), whereas the
      prevalence was 1.4% (95% CI, 0.07%-6.5%) in women without genital neoplasia (P = 
      .016). The prevalence ratio was 7.68 (95% CI, 1.01-58.21). LIMITATION: Women with
      normal results on high-resolution anoscopy were not submitted to random biopsies 
      for ethical reasons. Small lesions could be missed, and thus our findings might
      be underestimated. CONCLUSION: The prevalence of anal intraepithelial neoplasia
      is higher in women with genital neoplasia.
FAU - Koppe, Daniela Cerqueira
AU  - Koppe DC
AD  - Hospital de Clinicas de Porto Alegre, Programa de Pos-Graduacao: Ciencias em
      Gastroenterologia e Hepatologia, Faculdade de Medicina, Universidade Federal do
      Rio Grande do Sul, Porto Alegre, Brazil. danielakoppe@hotmail.com
FAU - Bandeira, Cleia Bertinetti
AU  - Bandeira CB
FAU - Rosa, Margarete Ribeiro Duarte
AU  - Rosa MR
FAU - Cambruzzi, Eduardo
AU  - Cambruzzi E
FAU - Meurer, Luise
AU  - Meurer L
FAU - Fagundes, Renato Borges
AU  - Fagundes RB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Dis Colon Rectum
JT  - Diseases of the colon and rectum
JID - 0372764
SB  - IM
MH  - Adult
MH  - Anus Neoplasms/*epidemiology/pathology
MH  - Biopsy
MH  - Brazil/epidemiology
MH  - Carcinoma in Situ/*epidemiology/pathology
MH  - Cervical Intraepithelial Neoplasia/*epidemiology/pathology
MH  - Chi-Square Distribution
MH  - Colposcopy
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Prevalence
MH  - Proctoscopy
MH  - Statistics, Nonparametric
MH  - Surveys and Questionnaires
MH  - Uterine Cervical Neoplasms/*epidemiology/pathology
EDAT- 2011/03/09 06:00
MHDA- 2011/06/03 06:00
CRDT- 2011/03/09 06:00
PHST- 2011/03/09 06:00 [entrez]
PHST- 2011/03/09 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
AID - 10.1007/DCR.0b013e3182061b34 [doi]
AID - 00003453-201104000-00008 [pii]
PST - ppublish
SO  - Dis Colon Rectum. 2011 Apr;54(4):442-5. doi: 10.1007/DCR.0b013e3182061b34.


PMID- 21383270
OWN - NLM
STAT- MEDLINE
DCOM- 20110531
LR  - 20151119
IS  - 1538-3628 (Electronic)
IS  - 1072-4710 (Linking)
VI  - 165
IP  - 3
DP  - 2011 Mar
TI  - The window of opportunity for treatment withdrawal.
PG  - 211-5
LID - 10.1001/archpediatrics.2011.4 [doi]
AB  - Physicians sometimes refer to a "window of opportunity" for withdrawing
      life-sustaining treatment in patients with acute severe brain injury. There is a 
      period of critical illness and physiological instability when treatment
      withdrawal is likely to be followed by death but prognosis is uncertain. If
      decisions are delayed, greater prognostic certainty can be achieved, but with the
      risk that the patient is no longer dependent on life support and survives with
      very severe disability. In this article I draw on the example of birth asphyxia
      and highlight the role that the window of opportunity sometimes plays in
      decisions about life-sustaining treatment in intensive care. I outline the
      potential arguments in favor of and against taking the window into account. I
      argue that it is, at least sometimes, ethical and appropriate for physicians and 
      parents to be influenced by the window of opportunity in their decisions about
      life-sustaining treatment.
FAU - Wilkinson, Dominic
AU  - Wilkinson D
AD  - Oxford Uehiro Centre for Practical Ethics, University of Oxford, Littlegate
      House, St Ebbes, Oxford, England. dominic.wilkinson@adelaide.edu.au
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Arch Pediatr Adolesc Med
JT  - Archives of pediatrics & adolescent medicine
JID - 9422751
SB  - IM
MH  - Critical Care
MH  - *Decision Making
MH  - Double Effect Principle
MH  - Humans
MH  - *Hypoxia-Ischemia, Brain
MH  - Infant, Newborn
MH  - Parents
MH  - Prognosis
MH  - Quality of Life
MH  - Respiration, Artificial
MH  - Uncertainty
MH  - *Withholding Treatment
EDAT- 2011/03/09 06:00
MHDA- 2011/06/01 06:00
CRDT- 2011/03/09 06:00
PHST- 2011/03/09 06:00 [entrez]
PHST- 2011/03/09 06:00 [pubmed]
PHST- 2011/06/01 06:00 [medline]
AID - 165/3/211 [pii]
AID - 10.1001/archpediatrics.2011.4 [doi]
PST - ppublish
SO  - Arch Pediatr Adolesc Med. 2011 Mar;165(3):211-5. doi:
      10.1001/archpediatrics.2011.4.


PMID- 21383222
OWN - NLM
STAT- MEDLINE
DCOM- 20110705
LR  - 20111017
IS  - 1558-7118 (Electronic)
IS  - 1557-2625 (Linking)
VI  - 24
IP  - 2
DP  - 2011 Mar-Apr
TI  - Living on the edge.
PG  - 211-3
LID - 10.3122/jabfm.2011.02.090185 [doi]
AB  - This essay describes a remarkable patient with severe medical and psychological
      problems who died a tragic death when she was only 46 years old. Despite
      suffering early coronary artery disease, persistent abuse from her spouse, and
      caring for a daughter with severe physical handicaps, the patient did not
      complain or seek pity for her condition. Rather, through her belief in God and a 
      focus on the day forward rather than the day behind, she reminds clinicians that 
      the sum of a person's life is more than their medical problems. After the
      patient's death, her husband's medical problems force him to seek care; this
      raised ethical issues because the doctor who was treating him also cared for his 
      wife.
FAU - Goldstein, Adam O
AU  - Goldstein AO
AD  - Department of Family Medicine, University of North Carolina School of Medicine,
      Chapel Hill, NC 27599, USA. aog@med.unc.edu
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Am Board Fam Med
JT  - Journal of the American Board of Family Medicine : JABFM
JID - 101256526
SB  - IM
CIN - J Am Board Fam Med. 2011 Sep-Oct;24(5):617; author reply 618. PMID: 21900448
MH  - Anxiety/complications
MH  - Coronary Disease/complications/*psychology
MH  - Family
MH  - Fatal Outcome
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Religion
MH  - Smoking/adverse effects/psychology
MH  - Spouse Abuse/*psychology
EDAT- 2011/03/09 06:00
MHDA- 2011/07/06 06:00
CRDT- 2011/03/09 06:00
PHST- 2011/03/09 06:00 [entrez]
PHST- 2011/03/09 06:00 [pubmed]
PHST- 2011/07/06 06:00 [medline]
AID - 24/2/211 [pii]
AID - 10.3122/jabfm.2011.02.090185 [doi]
PST - ppublish
SO  - J Am Board Fam Med. 2011 Mar-Apr;24(2):211-3. doi: 10.3122/jabfm.2011.02.090185.


PMID- 21382253
OWN - NLM
STAT- MEDLINE
DCOM- 20110531
LR  - 20191027
IS  - 0256-9574 (Print)
VI  - 101
IP  - 3
DP  - 2011 Mar 1
TI  - Disclosure of child murder: a case study of ethical dilemmas in research.
PG  - 164, 166, 168
FAU - Sikweyiya, Yandisa Msimelelo
AU  - Sikweyiya YM
AD  - South African Medical Research Council. yandisa.sikweyiya@mrc.ac.za
FAU - Jewkes, Rachel
AU  - Jewkes R
LA  - eng
PT  - Journal Article
DEP - 20110301
PL  - South Africa
TA  - S Afr Med J
JT  - South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
JID - 0404520
SB  - IM
MH  - Child Abuse/legislation & jurisprudence
MH  - Child Welfare/legislation & jurisprudence
MH  - Child, Preschool
MH  - Disclosure/*ethics/legislation & jurisprudence
MH  - *Ethics, Research
MH  - Homicide/*legislation & jurisprudence
MH  - Humans
MH  - Police
MH  - *Research Personnel
MH  - Research Subjects
MH  - South Africa
EDAT- 2011/03/09 06:00
MHDA- 2011/06/01 06:00
CRDT- 2011/03/09 06:00
PHST- 2010/08/16 00:00 [received]
PHST- 2010/09/15 00:00 [accepted]
PHST- 2011/03/09 06:00 [entrez]
PHST- 2011/03/09 06:00 [pubmed]
PHST- 2011/06/01 06:00 [medline]
AID - 10.7196/samj.4461 [doi]
PST - epublish
SO  - S Afr Med J. 2011 Mar 1;101(3):164, 166, 168. doi: 10.7196/samj.4461.


PMID- 21382185
OWN - NLM
STAT- MEDLINE
DCOM- 20110809
LR  - 20161125
IS  - 1754-9485 (Electronic)
IS  - 1754-9477 (Linking)
VI  - 55
IP  - 1
DP  - 2011 Feb
TI  - Incidental findings from lung CT scans: implications for research.
PG  - 20-5
LID - 10.1111/j.1754-9485.2010.02224.x [doi]
AB  - INTRODUCTION: We aimed to evaluate the number and nature of incidental findings
      in CT chest scans in the context of a study of the pulmonary effects of cannabis.
      METHODS: Three hundred fifty-seven participants were recruited: 78 cannabis-only 
      smokers, 92 tobacco-only smokers, 106 smokers of cannabis and tobacco and 81
      never smokers. All participants underwent a high-resolution CT scan of their
      thorax. Two radiologists read the scans. Associations between abnormalities and
      age, sex, tobacco and cannabis smoking status were expressed as odds ratios (OR) 
      with 95% confidence interval. RESULTS: Seventy-six findings requiring referral or
      further investigations were found in 71/357 (19.9%) of participants. In
      multivariate analyses, only older age, OR (per decade) 2.1 (1.4 to 3.0), was
      associated with a respiratory abnormality on the CT scan. A total of 37/76
      (48.7%) of the abnormalities detected were extra-pulmonary, with findings
      observed across a wide range of organ systems. Only older age, OR (per decade)
      1.7 (1.2 to 2.5), was associated with a non-respiratory abnormality. CONCLUSION: 
      The common occurrence of abnormal findings requiring referral or further
      investigations raises practical, ethical and medico-legal issues which need to be
      carefully considered in research programmes utilising chest CT scanning.
CI  - (c) 2011 The Authors. Journal of Medical Imaging and Radiation Oncology (c) 2011 
      The Royal Australian and New Zealand College of Radiologists.
FAU - Aldington, Sarah
AU  - Aldington S
AD  - Medical Research Institute of New Zealand, Wellington, New Zealand.
FAU - Shirtcliffe, Philippa
AU  - Shirtcliffe P
FAU - Nowitz, Mike
AU  - Nowitz M
FAU - Kingzett-Taylor, Andrew
AU  - Kingzett-Taylor A
FAU - Tweed, Mike
AU  - Tweed M
FAU - Weatherall, Mark
AU  - Weatherall M
FAU - Soriano, Joan B
AU  - Soriano JB
FAU - Beasley, Richard
AU  - Beasley R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - J Med Imaging Radiat Oncol
JT  - Journal of medical imaging and radiation oncology
JID - 101469340
SB  - IM
MH  - Comorbidity
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Incidental Findings
MH  - Lung/*diagnostic imaging
MH  - Lung Diseases/*diagnostic imaging/*epidemiology
MH  - Male
MH  - Middle Aged
MH  - New Zealand/epidemiology
MH  - Prevalence
MH  - Radiography, Thoracic/*statistics & numerical data
MH  - Reproducibility of Results
MH  - Respiration Disorders/*diagnostic imaging/*epidemiology
MH  - Sensitivity and Specificity
MH  - Tomography, X-Ray Computed/*statistics & numerical data
EDAT- 2011/03/09 06:00
MHDA- 2011/08/10 06:00
CRDT- 2011/03/09 06:00
PHST- 2011/03/09 06:00 [entrez]
PHST- 2011/03/09 06:00 [pubmed]
PHST- 2011/08/10 06:00 [medline]
AID - 10.1111/j.1754-9485.2010.02224.x [doi]
PST - ppublish
SO  - J Med Imaging Radiat Oncol. 2011 Feb;55(1):20-5. doi:
      10.1111/j.1754-9485.2010.02224.x.


PMID- 21382183
OWN - NLM
STAT- MEDLINE
DCOM- 20110809
LR  - 20111117
IS  - 1754-9485 (Electronic)
IS  - 1754-9477 (Linking)
VI  - 55
IP  - 1
DP  - 2011 Feb
TI  - Association between preoperative magnetic resonance imaging, pain intensity and
      quantitative sensory testing in patients awaiting lumbar diskectomy.
PG  - 4-10
LID - 10.1111/j.1754-9485.2010.02222.x [doi]
AB  - INTRODUCTION: Magnetic resonance imaging (MRI) offers important information
      regarding the morphology, location and size of a herniated disc, which influences
      the decision to offer lumbar diskectomy (LD). This study aims to examine the
      association between clinical neurophysiologic indices including pain intensity
      and quantitative sensory testing (QST), and the degree of lumbar nerve root
      compromise depicted on magnetic resonance (MR) in patients awaiting LD. METHODS: 
      With institutional ethical approval, 16 patients (American Society of
      Anaesthesiologists Grades I-II, 18-65 years) with radicular pain for greater than
      3 months undergoing elective LD were studied. Preoperative pain was assessed
      using (i) a visual analogue scale measuring pain intensity at rest and with
      movement and (ii) by quantifying pain sensory thresholds (St), pain perception
      thresholds (PPt), and pain tolerance threshold (PTt) using QST. MR images were
      independently graded by two radiologists blinded to the clinical data using the
      Pfirrmann grading system. Statistical analyses using Student's t-tests and
      Pearson's correlation were preformed where appropriate. RESULTS: This study
      showed that: (i) findings on MR imaging corresponded with the symptomatic side
      and distribution of the pain; (ii) the degree of nerve root compromise, detected 
      on MRI correlated with increased pain intensity at rest; and (iii) QST identified
      a trend towards higher St, PPt and PTt in patients with higher Pfirrmann grades. 
      CONCLUSIONS: The Pfirrmann grading system of nerve root compromise may be
      clinically useful preoperatively as a method of identifying individuals who would
      benefit most from LD. However, additional studies with greater patient numbers
      and longer follow-up are required to definitively confirm the findings of this
      study.
CI  - (c) 2011 The Authors. Journal of Medical Imaging and Radiation Oncology (c) 2011 
      The Royal Australian and New Zealand College of Radiologists.
FAU - Hegarty, Dominic
AU  - Hegarty D
AD  - Department of Anaesthetics Radiology, Cork University Hospital, Cork, Ireland.
FAU - O'Connor, Owen J
AU  - O'Connor OJ
FAU - Moore, Micheal
AU  - Moore M
FAU - O'Regan, Kevin N
AU  - O'Regan KN
FAU - Shorten, George
AU  - Shorten G
FAU - Maher, Michael M
AU  - Maher MM
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Med Imaging Radiat Oncol
JT  - Journal of medical imaging and radiation oncology
JID - 101469340
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Diskectomy
MH  - Female
MH  - Humans
MH  - Intervertebral Disc Displacement/*diagnosis/*surgery
MH  - Lumbar Vertebrae/*surgery
MH  - Male
MH  - Middle Aged
MH  - Pain Measurement/*methods
MH  - Patient Selection
MH  - Preoperative Care/methods
MH  - Prognosis
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Young Adult
EDAT- 2011/03/09 06:00
MHDA- 2011/08/10 06:00
CRDT- 2011/03/09 06:00
PHST- 2011/03/09 06:00 [entrez]
PHST- 2011/03/09 06:00 [pubmed]
PHST- 2011/08/10 06:00 [medline]
AID - 10.1111/j.1754-9485.2010.02222.x [doi]
PST - ppublish
SO  - J Med Imaging Radiat Oncol. 2011 Feb;55(1):4-10. doi:
      10.1111/j.1754-9485.2010.02222.x.


PMID- 21382003
OWN - NLM
STAT- MEDLINE
DCOM- 20110517
LR  - 20201219
IS  - 1326-5377 (Electronic)
IS  - 0025-729X (Linking)
VI  - 194
IP  - 5
DP  - 2011 Mar 7
TI  - Trade in human tissue products.
PG  - 263-5
AB  - Trade in human tissue in Australia is prohibited by state law, and in ethical
      guidelines by the National Health and Medical Research Council: National
      statement on ethical conduct in human research; Organ and tissue donation by
      living donors: guidelines for ethical practice for health professionals. However,
      trade in human tissue products is a common practice especially for:
      reconstructive orthopaedic or plastic surgery; novel human tissue products such
      as a replacement trachea created by using human mesenchymal stem cells;
      biomedical research using cell lines, DNA and protein provided through biobanks. 
      Cost pressures on these have forced consideration of commercial models to sustain
      their operations. Both the existing and novel activities require a robust
      framework to enable commercial uses of human tissue products while maintaining
      community acceptability of such practices, but to date no such framework exists. 
      In this article, we propose a model ethical framework for ethical governance
      which identifies specific ethical issues such as: privacy; unique value of a
      person's tissue; commodification of the body; equity and benefit to the
      community; perverse incentives; and "attenuation" as a potentially useful concept
      to help deal with the broad range of subjective views relevant to whether it is
      acceptable to commercialise certain human tissue products.
FAU - Tonti-Filippini, Nicholas
AU  - Tonti-Filippini N
AD  - John Paul II Institute for Marriage and Family, Melbourne, VIC, Australia.
      ntonti-filippini@jp2institute.org
FAU - Zeps, Nikolajs
AU  - Zeps N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Med J Aust
JT  - The Medical journal of Australia
JID - 0400714
SB  - IM
MH  - Australia
MH  - *Bioethical Issues
MH  - Biological Specimen Banks/legislation & jurisprudence
MH  - Commerce
MH  - *Ethics, Research
MH  - Humans
MH  - Organ Transplantation/legislation & jurisprudence
MH  - Privacy
EDAT- 2011/03/09 06:00
MHDA- 2011/05/18 06:00
CRDT- 2011/03/09 06:00
PHST- 2010/06/18 00:00 [received]
PHST- 2010/09/13 00:00 [accepted]
PHST- 2011/03/09 06:00 [entrez]
PHST- 2011/03/09 06:00 [pubmed]
PHST- 2011/05/18 06:00 [medline]
AID - ton10644_fm [pii]
AID - 10.5694/j.1326-5377.2011.tb02961.x [doi]
PST - ppublish
SO  - Med J Aust. 2011 Mar 7;194(5):263-5. doi: 10.5694/j.1326-5377.2011.tb02961.x.


PMID- 21381936
OWN - NLM
STAT- MEDLINE
DCOM- 20110714
LR  - 20110308
IS  - 1745-3062 (Electronic)
IS  - 1745-3054 (Linking)
VI  - 34
IP  - 1
DP  - 2011 Mar
TI  - Ethical dimensions to reflection.
PG  - 36-7
LID - 10.3109/17453054.2011.550851 [doi]
FAU - Bryson, David
AU  - Bryson D
AD  - University of Derby, UK. d.bryson@derby.ac.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Vis Commun Med
JT  - Journal of visual communication in medicine
JID - 101254059
SB  - IM
MH  - Confidentiality/ethics
MH  - *Ethics, Clinical
MH  - Humans
MH  - Judgment/*ethics
MH  - Perception/*ethics
EDAT- 2011/03/09 06:00
MHDA- 2011/07/16 06:00
CRDT- 2011/03/09 06:00
PHST- 2011/03/09 06:00 [entrez]
PHST- 2011/03/09 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
AID - 10.3109/17453054.2011.550851 [doi]
PST - ppublish
SO  - J Vis Commun Med. 2011 Mar;34(1):36-7. doi: 10.3109/17453054.2011.550851.


PMID- 21381794
OWN - NLM
STAT- MEDLINE
DCOM- 20110617
LR  - 20220311
IS  - 1533-0338 (Electronic)
IS  - 1533-0338 (Linking)
VI  - 10
IP  - 2
DP  - 2011 Apr
TI  - Geometric performance and efficiency of an optical tracking system for daily
      pre-treatment positioning in pelvic radiotherapy patients.
PG  - 163-70
AB  - The purpose of this study was to characterize the accuracy of a novel in-house
      optical tracking system (OTS), and to determine its efficiency for daily
      pre-treatment positioning of pelvic radiotherapy patients compared to
      conventional optical distance indicator (ODI) methodology. The OTS is comprised
      of a passive infrared stereoscopic camera, and custom control software for use in
      assisting radiotherapy patient setup. Initially, the system was calibrated and
      tested for stability inside a radiation therapy treatment room. Subsequently,
      under an ethics approved protocol, the clinical efficiency of the OTS was
      compared to conventional ODI setup methodology through 17 pelvic radiotherapy
      patients. Differences between orthogonal source-to-skin distance (SSD) readings
      and overall set-up time resultant from both systems were compared. The precision 
      of the OTS was 0.01 +/- 0.01 mm, 0.02 +/- 0.02 mm, and -0.01 +/- 0.06 mm in the
      left/right (L/R), anterior/posterior (A/P), and cranial/caudal (C/C) directions, 
      respectively. Discrepancies measured between the linac radiographic center in the
      treatment room and the calibrated origin of the camera (OTS) by two independent
      observers was submillimeter. Analysis of 146 fractions from 17 patients showed a 
      high correlation between the SSD readings of the OTS and ODI setup methodologies 
      (r = 0.99). The average time for pre-treatment positioning using the OTS couch
      shift calculation was 2.60 +/- 0.69 minutes, and for conventional ODI setup, 3.62
      +/- 0.82 minutes; the difference of 1.02 minutes was statistically significant (p
      < 0.001). In conclusion, the OTS is a precise and robust tool for use as an
      independent check of treatment room patient positioning. The system is indicated 
      as geometrically equivalent to current methods of daily pre-treatment patient
      positioning with potential for gains in efficiency by decreasing setup times in
      the treatment room.
FAU - Li, Winnie
AU  - Li W
AD  - Radiation Medicine Program, Level 2B Cobalt Lounge, Princess Margaret Hospital,
      610 University Ave., Toronto, Ontario, Canada M5G 2M9. Winnie.Li@rmp.uhn.on.ca
FAU - Sie, Fanny
AU  - Sie F
FAU - Bootsma, Gregory
AU  - Bootsma G
FAU - Moseley, Douglas
AU  - Moseley D
FAU - Catton, Charles N
AU  - Catton CN
FAU - Jaffray, David A
AU  - Jaffray DA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Technol Cancer Res Treat
JT  - Technology in cancer research & treatment
JID - 101140941
SB  - IM
MH  - Calibration
MH  - Female
MH  - Genital Neoplasms, Female/*radiotherapy
MH  - Humans
MH  - Optical Devices
MH  - Radiotherapy Planning, Computer-Assisted/instrumentation/*methods
MH  - Urogenital Neoplasms/*radiotherapy
EDAT- 2011/03/09 06:00
MHDA- 2011/06/18 06:00
CRDT- 2011/03/09 06:00
PHST- 2011/03/09 06:00 [entrez]
PHST- 2011/03/09 06:00 [pubmed]
PHST- 2011/06/18 06:00 [medline]
AID - c4313/Geometric-Performance-and-Efficiency-of-an-Optical-Tracking-System-for-Dail
      y-Pre-treatment-Positioning-in-Pelvic-Radiotherapy-Patients-163-170-p17851.html
      [pii]
AID - 10.7785/tcrt.2012.500191 [doi]
PST - ppublish
SO  - Technol Cancer Res Treat. 2011 Apr;10(2):163-70. doi: 10.7785/tcrt.2012.500191.


PMID- 21381480
OWN - NLM
STAT- MEDLINE
DCOM- 20110419
LR  - 20170214
IS  - 1757-9139 (Print)
IS  - 1757-9147 (Linking)
VI  - 131
IP  - 1
DP  - 2011 Jan
TI  - An emerging model for publishing and using open educational resources in public
      health.
PG  - 38-43
AB  - INTRODUCTION: The open source revolution has enabled the development of open
      educational resources (OER) and the potential for sharing lessons learned. We
      present a potential model for publishing OER in public health to inform workforce
      development. METHODS: As part of the PHORUS (Public Health Open Resources for the
      University Sector) Project, a review of the literature relating to the
      development of OER was followed by an online search for OER resources relating
      specifically to public health. Furthermore, a Delphi study was conducted to
      identify and prioritize barriers and enablers to the production and use of public
      health OER. RESULTS: A wide array of OER literature was identified, although
      there were a limited number of public health-related papers. The key concepts
      influencing public health OER release found in the literature were identified as 
      quality, ethics and values, rewards, risks and practical aspects, such as
      technological developments. These concepts were then further developed through
      the PHORUS project research findings to produce the basis of a potential model
      for OER development in public health. DISCUSSION/CONCLUSION: The synthesis of a
      literature review and Delphi study has produced a potential model to guide the
      development of OER in public health. The model provides a matrix where the
      questions about whether and how an academic can produce and publish OER are
      answered, according to various risks and benefits to them and their institution. 
      We hope that this will provide practical assistance and encouragement for the
      academic public health community to create and share OER.
FAU - Hemingway, A
AU  - Hemingway A
AD  - School of Health and Social Care, Bournemouth University, Bournemouth BH1 3LT UK.
      ahemingway@bournemouth.ac.uk
FAU - Angell, C
AU  - Angell C
FAU - Hartwell, H
AU  - Hartwell H
FAU - Heller, Richard F
AU  - Heller RF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Perspect Public Health
JT  - Perspectives in public health
JID - 101499631
SB  - IM
MH  - Databases, Bibliographic
MH  - Delphi Technique
MH  - Education, Public Health Professional/*methods
MH  - Humans
MH  - Information Dissemination/*methods
MH  - *Public Health
MH  - *Publishing
EDAT- 2011/03/09 06:00
MHDA- 2011/04/20 06:00
CRDT- 2011/03/09 06:00
PHST- 2011/03/09 06:00 [entrez]
PHST- 2011/03/09 06:00 [pubmed]
PHST- 2011/04/20 06:00 [medline]
AID - 10.1177/1757913910391034 [doi]
PST - ppublish
SO  - Perspect Public Health. 2011 Jan;131(1):38-43. doi: 10.1177/1757913910391034.


PMID- 21381185
OWN - NLM
STAT- MEDLINE
DCOM- 20110609
LR  - 20220309
IS  - 1542-0760 (Electronic)
IS  - 1542-0752 (Linking)
VI  - 91 Suppl 1
DP  - 2011 Mar
TI  - Paper 6: EUROCAT member registries: organization and activities.
PG  - S51-S100
LID - 10.1002/bdra.20775 [doi]
AB  - BACKGROUND: EUROCAT is a network of population-based congenital anomaly
      registries providing standardized epidemiologic information on congenital
      anomalies in Europe. There are three types of EUROCAT membership: full,
      associate, or affiliate. Full member registries send individual records of all
      congenital anomalies covered by their region. Associate members transmit
      aggregate case counts for each EUROCAT anomaly subgroup by year and by type of
      birth. This article describes the organization and activities of each of the
      current 29 full member and 6 associate member registries of EUROCAT. METHODS:
      Each registry description provides information on the history and funding of the 
      registry, population coverage including any changes in coverage over time,
      sources for ascertaining cases of congenital anomalies, and upper age limit for
      registering cases of congenital anomalies. It also details the legal requirements
      relating to termination of pregnancy for fetal anomalies, the definition of
      stillbirths and fetal deaths, and the prenatal screening policy within the
      registry. Information on availability of exposure information and denominators is
      provided. The registry description describes how each registry conforms to the
      laws and guidelines regarding ethics, consent, and confidentiality issues within 
      their own jurisdiction. Finally, information on electronic and web-based data
      capture, recent registry activities, and publications relating to congenital
      anomalies, along with the contact details of the registry leader, are provided.
      CONCLUSIONS: The registry description gives a detailed account of the
      organizational and operational aspects of each registry and is an invaluable
      resource that aids interpretation and evaluation of registry prevalence data.
CI  - Copyright (c) 2011 Wiley-Liss, Inc.
FAU - Greenlees, Ruth
AU  - Greenlees R
AD  - University of Ulster, Newtownabbey, Co Antrim, Northern Ireland, United Kingdom. 
      r.greenlees@ulster.ac.uk
FAU - Neville, Amanda
AU  - Neville A
FAU - Addor, Marie-Claude
AU  - Addor MC
FAU - Amar, Emmanuelle
AU  - Amar E
FAU - Arriola, Larraitz
AU  - Arriola L
FAU - Bakker, Marian
AU  - Bakker M
FAU - Barisic, Ingeborg
AU  - Barisic I
FAU - Boyd, Patricia A
AU  - Boyd PA
FAU - Calzolari, Elisa
AU  - Calzolari E
FAU - Doray, Berenice
AU  - Doray B
FAU - Draper, Elizabeth
AU  - Draper E
FAU - Vollset, Stein Emil
AU  - Vollset SE
FAU - Garne, Ester
AU  - Garne E
FAU - Gatt, Miriam
AU  - Gatt M
FAU - Haeusler, Martin
AU  - Haeusler M
FAU - Kallen, Karin
AU  - Kallen K
FAU - Khoshnood, Babak
AU  - Khoshnood B
FAU - Latos-Bielenska, Anna
AU  - Latos-Bielenska A
FAU - Martinez-Frias, Maria-Luisa
AU  - Martinez-Frias ML
FAU - Materna-Kiryluk, Anna
AU  - Materna-Kiryluk A
FAU - Dias, Carlos Matias
AU  - Dias CM
FAU - McDonnell, Bob
AU  - McDonnell B
FAU - Mullaney, Carmel
AU  - Mullaney C
FAU - Nelen, Vera
AU  - Nelen V
FAU - O'Mahony, Mary
AU  - O'Mahony M
FAU - Pierini, Anna
AU  - Pierini A
FAU - Queisser-Luft, Annette
AU  - Queisser-Luft A
FAU - Randrianaivo-Ranjatoelina, Hanitra
AU  - Randrianaivo-Ranjatoelina H
FAU - Rankin, Judith
AU  - Rankin J
FAU - Rissmann, Anke
AU  - Rissmann A
FAU - Ritvanen, Annukka
AU  - Ritvanen A
FAU - Salvador, Joaquin
AU  - Salvador J
FAU - Sipek, Antonin
AU  - Sipek A
FAU - Tucker, David
AU  - Tucker D
FAU - Verellen-Dumoulin, Christine
AU  - Verellen-Dumoulin C
FAU - Wellesley, Diana
AU  - Wellesley D
FAU - Wertelecki, Wladimir
AU  - Wertelecki W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110304
PL  - United States
TA  - Birth Defects Res A Clin Mol Teratol
JT  - Birth defects research. Part A, Clinical and molecular teratology
JID - 101155107
SB  - IM
MH  - Abortion, Induced/statistics & numerical data
MH  - Committee Membership
MH  - Congenital Abnormalities/*epidemiology
MH  - Databases, Factual
MH  - Europe/epidemiology
MH  - Evaluation Studies as Topic
MH  - Female
MH  - Fetal Death/epidemiology
MH  - Humans
MH  - Internet
MH  - *Population Surveillance
MH  - Pregnancy
MH  - Prenatal Diagnosis
MH  - Prevalence
MH  - Registries/*statistics & numerical data
MH  - Stillbirth/epidemiology
EDAT- 2011/03/08 06:00
MHDA- 2011/06/10 06:00
CRDT- 2011/03/08 06:00
PHST- 2010/11/22 00:00 [received]
PHST- 2010/11/30 00:00 [accepted]
PHST- 2011/03/08 06:00 [entrez]
PHST- 2011/03/08 06:00 [pubmed]
PHST- 2011/06/10 06:00 [medline]
AID - 10.1002/bdra.20775 [doi]
PST - ppublish
SO  - Birth Defects Res A Clin Mol Teratol. 2011 Mar;91 Suppl 1:S51-S100. doi:
      10.1002/bdra.20775. Epub 2011 Mar 4.


PMID- 21380736
OWN - NLM
STAT- MEDLINE
DCOM- 20131122
LR  - 20121204
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 18
IP  - 4
DP  - 2012 Dec
TI  - Civil engineering at the crossroads in the twenty-first century.
PG  - 681-7
LID - 10.1007/s11948-011-9258-2 [doi]
AB  - The twenty-first century presents a major challenge for civil engineering. The
      magnitude and future importance of some of the problems perceived by society are 
      directly related to the field of the civil engineer, implying an inescapable
      burden of responsibility for a group whose technical soundness, rational approach
      and efficiency is highly valued and respected by the citizen. However, the
      substantial changes in society and in the way it perceives the problems that it
      considers important call for a thorough review of our structures, both
      professional and educational; so that our profession, with its undeniable
      historical prestige, may modernize certain approaches and attitudes in order to
      continue to be a reliable instrument in the service of society, giving priority
      from an ethical standpoint to its actions in pursuit of "the public good". It
      possesses important tools to facilitate this work (new technologies, the
      development of communications, the transmission of scientific thought....); but
      there is nevertheless a need for deep reflection on the very essence of civil
      engineering: what we want it to be in the future, and the ability and willingness
      to take the lead at a time when society needs disinterested messages, technically
      supported, reasonably presented and dispassionately transmitted.
FAU - Ramirez, Francisco
AU  - Ramirez F
AD  - Department of Projects and Rural Engineering, Public University of Navarre,
      31006, Pamplona, Spain. 18frc@ciccp.es
FAU - Seco, Andres
AU  - Seco A
LA  - eng
PT  - Journal Article
DEP - 20110306
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Engineering/ethics
MH  - Humans
MH  - *Social Responsibility
EDAT- 2011/03/08 06:00
MHDA- 2013/12/16 06:00
CRDT- 2011/03/08 06:00
PHST- 2010/11/17 00:00 [received]
PHST- 2011/01/28 00:00 [accepted]
PHST- 2011/03/08 06:00 [entrez]
PHST- 2011/03/08 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1007/s11948-011-9258-2 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2012 Dec;18(4):681-7. doi: 10.1007/s11948-011-9258-2. Epub 2011
      Mar 6.


PMID- 21380599
OWN - NLM
STAT- MEDLINE
DCOM- 20120606
LR  - 20211020
IS  - 1525-1497 (Electronic)
IS  - 0884-8734 (Linking)
VI  - 26
IP  - 9
DP  - 2011 Sep
TI  - Artificial nutrition and hydration: the evolution of ethics, evidence, and
      policy.
PG  - 1053-8
LID - 10.1007/s11606-011-1659-z [doi]
AB  - INTRODUCTION: The debate over use of artificial nutrition and hydration (ANH) in 
      terminal illness, including advanced dementia, remains contentious despite
      extensive ethical and empirical investigation. METHODS: For this narrative review
      we undertook a focused, selective review of literature reflecting ethical
      analysis, empirical assessment of outcomes, legal responses, and thinking within 
      the Roman Catholic religious tradition. RESULTS: The history of the debate over
      the past 60 years results from a complex interplay of ethical concerns, a growing
      empirical database, legal changes, public opinion, and financial as well as
      institutional concerns. Discussions of ANH today are often conducted without any 
      understanding of this historical context. DISCUSSION: Patients' interests could
      be better protected through remedial action at both the individual and the policy
      levels.
FAU - Brody, Howard
AU  - Brody H
AD  - Institute for the Medical Humanities, University of Texas Medical Branch, 301
      University Boulevard, Galveston, TX 77555-1311, USA. habrody@utmb.edu
FAU - Hermer, Laura D
AU  - Hermer LD
FAU - Scott, Larry D
AU  - Scott LD
FAU - Grumbles, L Lee
AU  - Grumbles LL
FAU - Kutac, Julie E
AU  - Kutac JE
FAU - McCammon, Susan D
AU  - McCammon SD
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110305
PL  - United States
TA  - J Gen Intern Med
JT  - Journal of general internal medicine
JID - 8605834
SB  - IM
MH  - Catholicism
MH  - *Ethics, Medical
MH  - Fluid Therapy/*ethics/trends
MH  - *Health Policy/legislation & jurisprudence/trends
MH  - Humans
MH  - Nutritional Support/*ethics/trends
MH  - Palliative Care/*ethics/legislation & jurisprudence/trends
PMC - PMC3157529
EDAT- 2011/03/08 06:00
MHDA- 2012/06/07 06:00
CRDT- 2011/03/08 06:00
PHST- 2010/08/04 00:00 [received]
PHST- 2011/02/04 00:00 [accepted]
PHST- 2011/01/24 00:00 [revised]
PHST- 2011/03/08 06:00 [entrez]
PHST- 2011/03/08 06:00 [pubmed]
PHST- 2012/06/07 06:00 [medline]
AID - 10.1007/s11606-011-1659-z [doi]
PST - ppublish
SO  - J Gen Intern Med. 2011 Sep;26(9):1053-8. doi: 10.1007/s11606-011-1659-z. Epub
      2011 Mar 5.


PMID- 21380487
OWN - NLM
STAT- MEDLINE
DCOM- 20110627
LR  - 20211020
IS  - 1537-744X (Electronic)
IS  - 1537-744X (Linking)
VI  - 11
DP  - 2011 Mar 1
TI  - Biometrics applications: technology, ethics, and health hazards. Special issue.
PG  - 529-31
LID - 10.1100/tsw.2011.53 [doi]
FAU - Tzaphlidou, Margaret
AU  - Tzaphlidou M
AD  - Department of Medical Physics, Medical School, Ioannina University, Ioannina
      Greece. mtzaphli@uoi.gr
FAU - Pavlidou, Fotini-Niovi
AU  - Pavlidou FN
LA  - eng
PT  - Introductory Journal Article
DEP - 20110301
PL  - United States
TA  - ScientificWorldJournal
JT  - TheScientificWorldJournal
JID - 101131163
SB  - IM
MH  - *Biometry
MH  - *Ethics
MH  - Humans
PMC - PMC5720074
EDAT- 2011/03/08 06:00
MHDA- 2011/06/28 06:00
CRDT- 2011/03/08 06:00
PHST- 2011/03/08 06:00 [entrez]
PHST- 2011/03/08 06:00 [pubmed]
PHST- 2011/06/28 06:00 [medline]
AID - 10.1100/tsw.2011.53 [doi]
PST - epublish
SO  - ScientificWorldJournal. 2011 Mar 1;11:529-31. doi: 10.1100/tsw.2011.53.


PMID- 21380481
OWN - NLM
STAT- MEDLINE
DCOM- 20110627
LR  - 20211020
IS  - 1537-744X (Electronic)
IS  - 1537-744X (Linking)
VI  - 11
DP  - 2011 Mar 1
TI  - Democracies restricting democratic rights: some classical sources and
      implications for ethics of biometrics.
PG  - 463-73
LID - 10.1100/tsw.2011.47 [doi]
AB  - Ancient Greek and 17th century English philosophy are not usually discussed along
      with the ethics of biometrics and data sharing. Academic ethics today, however,
      suffers from a lack of background in classical texts. We may discuss whether
      biometrics and data sharing are consistent with democracy, but if we do not know 
      what democracy is, then we cannot know what actions are consistent with it. I
      shall discuss how and why democracies have restricted the rights of their
      citizens. I will give the most attention to two paradigms that have most
      influenced modern democratic thinking: 17th century English democracy and ancient
      Athens. I do not accept the dogma that the Athenians were obviously wrong to try 
      and then to condemn Socrates. His death-loving doctrine could not but have
      weakened the will of the youth to work and fight for the good of Athens. I will
      try to understand the Athenians' point of view and their need to defend their
      security. At the end, I will apply these lessons to biometrics and data sharing
      for security reasons.
FAU - Leavitt, Frank J
AU  - Leavitt FJ
AD  - Medical Ethics Centre, Faculty of Health Sciences, Ben Gurion University of the
      Negev, Beer Sheva, Israel. yeruham.l@gmail.com
LA  - eng
PT  - Historical Article
PT  - Journal Article
DEP - 20110301
PL  - United States
TA  - ScientificWorldJournal
JT  - TheScientificWorldJournal
JID - 101131163
SB  - IM
MH  - *Biometry
MH  - *Civil Rights
MH  - *Democracy
MH  - *Ethics
MH  - Greece
MH  - History, 17th Century
MH  - History, Ancient
PMC - PMC5720008
EDAT- 2011/03/08 06:00
MHDA- 2011/06/28 06:00
CRDT- 2011/03/08 06:00
PHST- 2011/03/08 06:00 [entrez]
PHST- 2011/03/08 06:00 [pubmed]
PHST- 2011/06/28 06:00 [medline]
AID - 10.1100/tsw.2011.47 [doi]
PST - epublish
SO  - ScientificWorldJournal. 2011 Mar 1;11:463-73. doi: 10.1100/tsw.2011.47.


PMID- 21379431
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20220408
IS  - 2005-6745 (Electronic)
IS  - 2005-6737 (Linking)
VI  - 52
IP  - 2
DP  - 2011 Feb
TI  - Realistic anatomical prostate models for surgical skills workshops using
      ballistic gelatin for nerve-sparing radical prostatectomy and fruit for simple
      prostatectomy.
PG  - 130-5
LID - 10.4111/kju.2011.52.2.130 [doi]
AB  - PURPOSE: Understanding of prostate anatomy has evolved as techniques have been
      refined and improved for radical prostatectomy (RP), particularly regarding the
      importance of the neurovascular bundles for erectile function. The objectives of 
      this study were to develop inexpensive and simple but anatomically accurate
      prostate models not involving human or animal elements to teach the terminology
      and practical aspects of nerve-sparing RP and simple prostatectomy (SP).
      MATERIALS AND METHODS: The RP model used a Foley catheter with ballistics gelatin
      in the balloon and mesh fabric (neurovascular bundles) and balloons (prostatic
      fascial layers) on either side for the practice of inter- and intrafascial
      techniques. The SP model required only a ripe clementine, for which the skin
      represented compressed normal prostate, the pulp represented benign tissue, and
      the pith mimicked fibrous adhesions. A modification with a balloon through the
      fruit center acted as a "urethra." RESULTS: Both models were easily created and
      successfully represented the principles of anatomical nerve-sparing RP and SP.
      Both models were tested in workshops by urologists and residents of differing
      levels with positive feedback. CONCLUSIONS: Low-fidelity models for prostate
      anatomy demonstration and surgical practice are feasible. They are inexpensive
      and simple to construct. Importantly, these models can be used for education on
      the practical aspects of nerve-sparing RP and SP. The models will require further
      validation as educational and competency tools, but as we move to an era in which
      human donors and animal experiments become less ethical and more difficult to
      complete, so too will low-fidelity models become more attractive.
FAU - Lawrentschuk, Nathan
AU  - Lawrentschuk N
AD  - Department of Urology and Surgical Oncology, Princess Margaret Hospital,
      University of Toronto, Toronto, Canada.
FAU - Lindner, Uri
AU  - Lindner U
FAU - Klotz, Laurence
AU  - Klotz L
LA  - eng
PT  - Journal Article
DEP - 20110221
PL  - Korea (South)
TA  - Korean J Urol
JT  - Korean journal of urology
JID - 101499376
PMC - PMC3045719
OTO - NOTNLM
OT  - Anatomic models
OT  - Autonomic pathways
OT  - Education
OT  - Fascia
OT  - Prostatectomy
EDAT- 2011/03/08 06:00
MHDA- 2011/03/08 06:01
CRDT- 2011/03/08 06:00
PHST- 2010/09/17 00:00 [received]
PHST- 2010/12/13 00:00 [accepted]
PHST- 2011/03/08 06:00 [entrez]
PHST- 2011/03/08 06:00 [pubmed]
PHST- 2011/03/08 06:01 [medline]
AID - 10.4111/kju.2011.52.2.130 [doi]
PST - ppublish
SO  - Korean J Urol. 2011 Feb;52(2):130-5. doi: 10.4111/kju.2011.52.2.130. Epub 2011
      Feb 21.


PMID- 21378616
OWN - NLM
STAT- MEDLINE
DCOM- 20110609
LR  - 20191112
IS  - 1750-8460 (Print)
IS  - 1750-8460 (Linking)
VI  - 72
IP  - 2
DP  - 2011 Feb
TI  - Medical futility: a commonly used and potentially abused idea in medical ethics.
PG  - 96-9
AB  - Hospital doctors frequently invoke the idea of medical futility in making
      decisions regarding end-of-life care. This concept of futility will be reviewed
      and the differing definitions and how it relates to other important principles in
      biomedical ethics discussed.
FAU - Thompson, Richard J
AU  - Thompson RJ
AD  - Northern Ireland Medical and Dental Training Agency, Graigavon Area Hospital,
      Portadown, UK.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Br J Hosp Med (Lond)
JT  - British journal of hospital medicine (London, England : 2005)
JID - 101257109
SB  - IM
MH  - Decision Making
MH  - *Ethics, Medical
MH  - Humans
MH  - *Medical Futility
MH  - *Personal Autonomy
MH  - Terminal Care/*ethics
MH  - Terminology as Topic
EDAT- 2011/03/08 06:00
MHDA- 2011/06/10 06:00
CRDT- 2011/03/08 06:00
PHST- 2011/03/08 06:00 [entrez]
PHST- 2011/03/08 06:00 [pubmed]
PHST- 2011/06/10 06:00 [medline]
AID - 10.12968/hmed.2011.72.2.96 [doi]
PST - ppublish
SO  - Br J Hosp Med (Lond). 2011 Feb;72(2):96-9. doi: 10.12968/hmed.2011.72.2.96.


PMID- 21378403
OWN - NLM
STAT- MEDLINE
DCOM- 20110713
LR  - 20211020
IS  - 1468-2060 (Electronic)
IS  - 0003-4967 (Linking)
VI  - 70
IP  - 6
DP  - 2011 Jun
TI  - Reporting of long-term extension studies: lack of consistency calls for
      consensus.
PG  - 886-90
LID - 10.1136/ard.2010.143420 [doi]
AB  - Double-blind, randomised controlled studies represent the gold-standard approach 
      to determine the safety and efficacy of therapeutic interventions. In chronic
      conditions such as rheumatoid arthritis (RA), long-term data are vital to confirm
      maintenance of effect and identify potential safety signals. The recent
      introduction of numerous biological therapies for RA has been followed by various
      long-term extension (LTE) studies. Although useful, the design and method of
      analysis in such studies vary significantly, partly due to their complexity. This
      viewpoint highlights general considerations needed when undertaking a LTE study
      and illustrates the lack of consistency in studies of RA to date. It addresses
      issues of selection bias, patient discontinuation and missing data. Although used
      for safety reporting, the lack of adequate powering makes LTE studies of limited 
      benefit. Ethical considerations and challenges are highlighted, including
      potential conflicts of interest. Finally, the authors suggest the need for
      consensus to ensure more reliable interpretation and application of data for
      clinical practice. Following the development of guidelines on reporting of
      clinical trials in RA and more recently, registry data, a similar approach for
      LTE studies would be a useful endeavour.
FAU - Buch, Maya H
AU  - Buch MH
AD  - Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine,
      University of Leeds, 2nd Floor, Chapel Allerton Hospital, Chapeltown Road, Leeds 
      LS7 4SA, UK. m.buch@leeds.ac.uk
FAU - Aletaha, Daniel
AU  - Aletaha D
FAU - Emery, Paul
AU  - Emery P
FAU - Smolen, Josef S
AU  - Smolen JS
LA  - eng
GR  - 18475/ARC_/Arthritis Research UK/United Kingdom
GR  - 18475/VAC_/Versus Arthritis/United Kingdom
PT  - Journal Article
DEP - 20110306
PL  - England
TA  - Ann Rheum Dis
JT  - Annals of the rheumatic diseases
JID - 0372355
RN  - 0 (Antirheumatic Agents)
SB  - IM
MH  - Antirheumatic Agents/*therapeutic use
MH  - Arthritis, Rheumatoid/*drug therapy
MH  - Consensus
MH  - Ethics, Research
MH  - Follow-Up Studies
MH  - Humans
MH  - Randomized Controlled Trials as Topic/*standards
MH  - Research Design/standards
MH  - Treatment Outcome
EDAT- 2011/03/08 06:00
MHDA- 2011/07/14 06:00
CRDT- 2011/03/08 06:00
PHST- 2011/03/08 06:00 [entrez]
PHST- 2011/03/08 06:00 [pubmed]
PHST- 2011/07/14 06:00 [medline]
AID - ard.2010.143420 [pii]
AID - 10.1136/ard.2010.143420 [doi]
PST - ppublish
SO  - Ann Rheum Dis. 2011 Jun;70(6):886-90. doi: 10.1136/ard.2010.143420. Epub 2011 Mar
      6.


PMID- 21378127
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20220408
IS  - 1476-6256 (Electronic)
IS  - 0002-9262 (Linking)
VI  - 173
IP  - 8
DP  - 2011 Apr 15
TI  - Estimates of the duration of untreated acute malnutrition in children from Niger.
PG  - 932-40
LID - 10.1093/aje/kwq436 [doi]
AB  - Expected incidence of acute malnutrition is the most appropriate measure for
      projecting the needs of a nutritional treatment program over time in terms of
      staffing, food, and other treatments, but direct estimation of incidence is
      rarely feasible at the onset of an intervention. While incidence may be
      approximated as prevalence/average duration, ethical constraints preclude
      measurement of the duration of acute malnutrition in the absence of treatment.
      The authors used a compartmental model to estimate the duration of untreated
      moderate acute malnutrition (MAM) and severe acute malnutrition (SAM) in children
      aged 6-60 months. The model was informed by data from a community-based cohort of
      children in Niger followed from August 2006 to March 2007. Maximum likelihood
      estimates for the duration of untreated MAM, defined by weight-for-height z score
      and middle upper arm circumference, were 75-81 days and 101-116 days,
      respectively. The duration of untreated SAM, defined by weight-for-height z
      score, was 45 days. The duration of untreated MAM appears to have been shorter
      among children aged 6-35 months compared with those aged 36-60 months. Such
      estimates of the duration, and thus incidence, of untreated malnutrition can be
      used to improve projections of program needs and estimates of the global burden
      of acute malnutrition.
FAU - Isanaka, Sheila
AU  - Isanaka S
AD  - Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, 
      Boston, MA 02115, USA. sisanaka@hsph.harvard.edu
FAU - Grais, Rebecca F
AU  - Grais RF
FAU - Briend, Andre
AU  - Briend A
FAU - Checchi, Francesco
AU  - Checchi F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110304
PL  - United States
TA  - Am J Epidemiol
JT  - American journal of epidemiology
JID - 7910653
SB  - IM
MH  - Age Factors
MH  - Body Weights and Measures
MH  - Child Nutrition Disorders/*epidemiology
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Epidemiologic Methods
MH  - Humans
MH  - Incidence
MH  - Infant
MH  - Niger/epidemiology
MH  - Nutrition Surveys/*methods
MH  - Severity of Illness Index
MH  - Time Factors
EDAT- 2011/03/08 06:00
MHDA- 2011/06/03 06:00
CRDT- 2011/03/08 06:00
PHST- 2011/03/08 06:00 [entrez]
PHST- 2011/03/08 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
AID - kwq436 [pii]
AID - 10.1093/aje/kwq436 [doi]
PST - ppublish
SO  - Am J Epidemiol. 2011 Apr 15;173(8):932-40. doi: 10.1093/aje/kwq436. Epub 2011 Mar
      4.


PMID- 21377304
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111103
LR  - 20120202
IS  - 1872-6283 (Electronic)
IS  - 0379-0738 (Linking)
VI  - 210
IP  - 1-3
DP  - 2011 Jul 15
TI  - Minimum requirements for application of ink dating methods based on solvent
      analysis in casework.
PG  - 52-62
LID - 10.1016/j.forsciint.2011.01.034 [doi]
AB  - Several ink dating methods based on solvents analysis using gas
      chromatography/mass spectrometry (GC/MS) were proposed in the last decades. These
      methods follow the drying of solvents from ballpoint pen inks on paper and seem
      very promising. However, several questions arose over the last few years among
      questioned documents examiners regarding the transparency and reproducibility of 
      the proposed techniques. These questions should be carefully studied for accurate
      and ethical application of this methodology in casework. Inspired by a real
      investigation involving ink dating, the present paper discusses this particular
      issue throughout four main topics: aging processes, dating methods, validation
      procedures and data interpretation. This work presents a wide picture of the ink 
      dating field, warns about potential shortcomings and also proposes some solutions
      to avoid reporting errors in court.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Weyermann, Celine
AU  - Weyermann C
AD  - Institut de Police Scientifique, University of Lausanne, Batochime, CH-1015
      Lausanne, Switzerland. celine.weyermann@unil.ch
FAU - Almog, Joseph
AU  - Almog J
FAU - Bugler, Jurgen
AU  - Bugler J
FAU - Cantu, Antonio A
AU  - Cantu AA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110304
PL  - Ireland
TA  - Forensic Sci Int
JT  - Forensic science international
JID - 7902034
EIN - Forensic Sci Int. 2012 Jan 10;214(1-3):214
EDAT- 2011/03/08 06:00
MHDA- 2011/03/08 06:01
CRDT- 2011/03/08 06:00
PHST- 2010/11/11 00:00 [received]
PHST- 2011/01/21 00:00 [revised]
PHST- 2011/01/25 00:00 [accepted]
PHST- 2011/03/08 06:00 [entrez]
PHST- 2011/03/08 06:00 [pubmed]
PHST- 2011/03/08 06:01 [medline]
AID - S0379-0738(11)00049-1 [pii]
AID - 10.1016/j.forsciint.2011.01.034 [doi]
PST - ppublish
SO  - Forensic Sci Int. 2011 Jul 15;210(1-3):52-62. doi:
      10.1016/j.forsciint.2011.01.034. Epub 2011 Mar 4.


PMID- 21377293
OWN - NLM
STAT- MEDLINE
DCOM- 20120316
LR  - 20220311
IS  - 1879-355X (Electronic)
IS  - 0360-3016 (Linking)
VI  - 82
IP  - 2
DP  - 2012 Feb 1
TI  - Stereotactic body radiotherapy for medically inoperable lung cancer: prospective,
      single-center study of 108 consecutive patients.
PG  - 967-73
LID - 10.1016/j.ijrobp.2010.12.039 [doi]
AB  - PURPOSE: To present the results of stereotactic body radiotherapy (SBRT) for
      medically inoperable patients with Stage I non-small-cell lung cancer (NSCLC) and
      contrast outcomes in patients with and without a pathologic diagnosis. METHODS
      AND MATERIALS: Between December 2004 and October 2008, 108 patients (114 tumors) 
      underwent treatment according to the prospective research ethics board-approved
      SBRT protocols at our cancer center. Of the 108 patients, 88 (81.5%) had
      undergone pretreatment whole-body [18F]-fluorodeoxyglucose positron emission
      tomography/computed tomography. A pathologic diagnosis was unavailable for 33
      (28.9%) of the 114 lesions. The SBRT schedules included 48 Gy in 4 fractions or
      54-60 Gy in 3 fractions for peripheral lesions and 50-60 Gy in 8-10 fractions for
      central lesions. Toxicity and radiologic response were assessed at the 3-6-month 
      follow-up visits using conventional criteria. RESULTS: The mean tumor diameter
      was 2.4-cm (range, 0.9-5.7). The median follow-up was 19.1 months (range,
      1-55.7). The estimated local control rate at 1 and 4 years was 92% (95%
      confidence interval [CI], 86-97%) and 89% (95% CI, 81-96%). The cause-specific
      survival rate at 1 and 4 years was 92% (95% CI, 87-98%) and 77% (95% CI, 64-89%),
      respectively. No statistically significant difference was found in the local,
      regional, and distant control between patients with and without pathologically
      confirmed NSCLC. The most common acute toxicity was Grade 1 or 2 fatigue (53 of
      108 patients). No toxicities of Grade 4 or greater were identified. CONCLUSIONS: 
      Lung SBRT for early-stage NSCLC resulted in excellent local control and
      cause-specific survival with minimal toxicity. The disease-specific outcomes were
      comparable for patients with and without a pathologic diagnosis. SBRT can be
      considered an option for selected patients with proven or presumed early-stage
      NSCLC.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Taremi, Mojgan
AU  - Taremi M
AD  - Radiation Medicine Program, Princess Margaret Hospital, Toronto, ON, Canada.
      mojgan.taremi@rmp.uhn.on.ca
FAU - Hope, Andrew
AU  - Hope A
FAU - Dahele, Max
AU  - Dahele M
FAU - Pearson, Shannon
AU  - Pearson S
FAU - Fung, Sharon
AU  - Fung S
FAU - Purdie, Thomas
AU  - Purdie T
FAU - Brade, Anthony
AU  - Brade A
FAU - Cho, John
AU  - Cho J
FAU - Sun, Alexander
AU  - Sun A
FAU - Bissonnette, Jean-Pierre
AU  - Bissonnette JP
FAU - Bezjak, Andrea
AU  - Bezjak A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110304
PL  - United States
TA  - Int J Radiat Oncol Biol Phys
JT  - International journal of radiation oncology, biology, physics
JID - 7603616
RN  - 0 (Radiopharmaceuticals)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cancer Care Facilities
MH  - Carcinoma, Non-Small-Cell Lung/diagnostic imaging/mortality/pathology/*surgery
MH  - Confidence Intervals
MH  - Disease-Free Survival
MH  - Dose Fractionation, Radiation
MH  - Female
MH  - Fluorodeoxyglucose F18
MH  - Humans
MH  - Lung Neoplasms/diagnostic imaging/mortality/pathology/*surgery
MH  - Male
MH  - Middle Aged
MH  - Multimodal Imaging
MH  - Ontario
MH  - Positron-Emission Tomography
MH  - Prospective Studies
MH  - Radiation Injuries/pathology
MH  - Radiopharmaceuticals
MH  - Radiosurgery/adverse effects/*methods
MH  - Radiotherapy, Image-Guided/methods
MH  - Survival Rate
MH  - Tomography, X-Ray Computed
MH  - Treatment Outcome
MH  - Tumor Burden
EDAT- 2011/03/08 06:00
MHDA- 2012/03/17 06:00
CRDT- 2011/03/08 06:00
PHST- 2010/08/27 00:00 [received]
PHST- 2010/12/19 00:00 [revised]
PHST- 2010/12/21 00:00 [accepted]
PHST- 2011/03/08 06:00 [entrez]
PHST- 2011/03/08 06:00 [pubmed]
PHST- 2012/03/17 06:00 [medline]
AID - S0360-3016(11)00027-7 [pii]
AID - 10.1016/j.ijrobp.2010.12.039 [doi]
PST - ppublish
SO  - Int J Radiat Oncol Biol Phys. 2012 Feb 1;82(2):967-73. doi:
      10.1016/j.ijrobp.2010.12.039. Epub 2011 Mar 4.


PMID- 21376810
OWN - NLM
STAT- MEDLINE
DCOM- 20111006
LR  - 20220408
IS  - 1096-1186 (Electronic)
IS  - 1043-6618 (Linking)
VI  - 64
IP  - 3
DP  - 2011 Sep
TI  - The development of medicines for children. Part of a series on Pediatric
      Pharmacology, guest edited by Gianvincenzo Zuccotti, Emilio Clementi, and Massimo
      Molteni.
PG  - 169-75
LID - 10.1016/j.phrs.2011.01.016 [doi]
AB  - The lack of availability of appropriate medicines for children is an extensive
      and well known problem. As a consequence off label or unlicensed administration
      of medicinal products in every day paediatric practice is frequent. A variety of 
      obstacles hinder the development of paediatric indications for drugs primarily
      intended for the adult market. The barriers to proper research on children's drug
      development include several complex factors, such as the limited commercial
      interest, lack of suitable infrastructure and competence for conducting
      paediatric clinical trials, difficulties in trial design, ethical worries and
      many others. Medicinal products used to treat children should be subjected to
      ethical research of high quality and be explicitly authorised for use in children
      as it happens in adults. Conducting adequate clinical trials in children is
      challenging and demanding. Identification of paediatric medical needs,
      extrapolation from adult data, modelling and simulation, specific clinical trial 
      methodology are important features in the development of drugs intended for
      children. Market forces alone have proven insufficient to stimulate adequate
      research aimed at specific authorisation of medicinal products for the paediatric
      population, and for that reason, following the US experience, the European
      Paediatric Regulation has been amended in January 2007 by the European
      Commission. The objective of the Paediatric Regulation is to improve the
      development of high quality and ethically researched medicines for children aged 
      0 to 17 years, to facilitate the availability of information on the use of
      medicines for children, without subjecting children to unnecessary trials, or
      delaying the authorisation of medicines for use in adults. The impact of the
      Paediatric Regulation reflects in an increase in the number of paediatric studies
      to be performed, even if a significant number of these studies have not started
      yet. The objective of this review is to describe the main regulatory and
      scientific features which play a role in the complex issue of paediatric drug
      development.
CI  - 2011 Elsevier Ltd. All rights reserved.
FAU - Rocchi, Francesca
AU  - Rocchi F
AD  - European Assessment Unit - Agenzia Italiana del Farmaco (AIFA), via del Tritone
      181, 00187 Rome, Italy. F.Rocchi@aifa.gov.it
FAU - Tomasi, Paolo
AU  - Tomasi P
LA  - eng
PT  - Editorial
PT  - Review
DEP - 20110303
PL  - Netherlands
TA  - Pharmacol Res
JT  - Pharmacological research
JID - 8907422
SB  - IM
MH  - Child
MH  - Clinical Trials as Topic
MH  - Drug Discovery/ethics/*legislation & jurisprudence/*methods
MH  - Drug and Narcotic Control
MH  - Europe
MH  - Humans
MH  - Legislation, Drug
MH  - Pediatrics/ethics/legislation & jurisprudence/methods
EDAT- 2011/03/08 06:00
MHDA- 2011/10/07 06:00
CRDT- 2011/03/08 06:00
PHST- 2011/01/26 00:00 [received]
PHST- 2011/01/27 00:00 [accepted]
PHST- 2011/03/08 06:00 [entrez]
PHST- 2011/03/08 06:00 [pubmed]
PHST- 2011/10/07 06:00 [medline]
AID - S1043-6618(11)00059-4 [pii]
AID - 10.1016/j.phrs.2011.01.016 [doi]
PST - ppublish
SO  - Pharmacol Res. 2011 Sep;64(3):169-75. doi: 10.1016/j.phrs.2011.01.016. Epub 2011 
      Mar 3.


PMID- 21376601
OWN - NLM
STAT- MEDLINE
DCOM- 20110921
LR  - 20220321
IS  - 1532-4036 (Electronic)
IS  - 0964-3397 (Linking)
VI  - 27
IP  - 3
DP  - 2011 Jun
TI  - The intensive care research coordinator position in Australia and New Zealand:
      Self-perception of professional development priorities and "best" and "worst"
      aspects of the position. A cross-sectional web-based study.
PG  - 129-37
LID - 10.1016/j.iccn.2011.02.002 [doi]
AB  - BACKGROUND: Many intensive care units (ICU) research coordinators (RCs) work in
      isolation with limited access to professional development and peer support. AIMS:
      (1) To map professional development priorities and "best" and "worst" aspects of 
      the ICU RC role. (2) To compare results of "best" and "worst" aspects to a
      similar 2004 study. METHODS: On-line study conducted from July 2009 to October
      2009. Respondents scored 26 individual items related to professional development 
      and described in free text "best" and "worst" aspects. RESULTS: 56 RCs
      participated. Maintaining high ethical standards for the research participant was
      ranked the highest priority. RCs had considerable interest but less confidence in
      completing own research. The "best" and "worst" aspects exposed three thematic
      clusters: work conditions; work environment; work role. Most often recorded
      notations were Work Conditions for "best" and work environment for "worst"
      aspects. CONCLUSION: RCs judge adherence to international research guidelines the
      most important pre-requisite for the position and wish involvement in research
      design and dissemination. With little change from 2004, inadequate peer support
      and unsatisfactory employment conditions constituted most of the "worst" aspects.
      Autonomy and working in the ICU team are the "best" aspects of the role in
      addition to the intellectual stimulation of research.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Roberts, Brigit
AU  - Roberts B
AD  - Department of Intensive Care, Sir Charles Gairdner Hospital, Perth, Western
      Australia, Australia. Brigit.Roberts@health.wa.gov.au
FAU - Eastwood, Glenn M
AU  - Eastwood GM
FAU - Raunow, Heike
AU  - Raunow H
FAU - Howe, Belinda
AU  - Howe B
FAU - Rickard, Claire M
AU  - Rickard CM
LA  - eng
PT  - Journal Article
DEP - 20110304
PL  - Netherlands
TA  - Intensive Crit Care Nurs
JT  - Intensive & critical care nursing
JID - 9211274
MH  - Adult
MH  - Australia
MH  - Clinical Nursing Research/*organization & administration
MH  - Critical Care
MH  - Data Collection
MH  - Female
MH  - Health Services Research/*organization & administration
MH  - Humans
MH  - *Intensive Care Units
MH  - Internet
MH  - Job Satisfaction
MH  - Male
MH  - Middle Aged
MH  - New Zealand
MH  - Young Adult
EDAT- 2011/03/08 06:00
MHDA- 2011/09/22 06:00
CRDT- 2011/03/08 06:00
PHST- 2010/12/07 00:00 [received]
PHST- 2011/02/02 00:00 [revised]
PHST- 2011/02/05 00:00 [accepted]
PHST- 2011/03/08 06:00 [entrez]
PHST- 2011/03/08 06:00 [pubmed]
PHST- 2011/09/22 06:00 [medline]
AID - S0964-3397(11)00010-3 [pii]
AID - 10.1016/j.iccn.2011.02.002 [doi]
PST - ppublish
SO  - Intensive Crit Care Nurs. 2011 Jun;27(3):129-37. doi: 10.1016/j.iccn.2011.02.002.
      Epub 2011 Mar 4.


PMID- 21376518
OWN - NLM
STAT- MEDLINE
DCOM- 20120207
LR  - 20180717
IS  - 1557-8615 (Electronic)
IS  - 0883-9441 (Linking)
VI  - 26
IP  - 5
DP  - 2011 Oct
TI  - Consent in critical care trials: a survey of Canadian research ethics boards and 
      critical care researchers.
PG  - 533.e11-533.e22
LID - S0883-9441(10)00348-5 [pii]
LID - 10.1016/j.jcrc.2010.12.009 [doi]
AB  - PURPOSE: Reliance on third party consent for patients without decision-making
      capacity presents unique challenges for critical care research. We compared the
      attitudes and beliefs of Canadian research ethics boards (REBs) and intensive
      care unit researchers toward the use of various consent models for a low-risk
      randomized controlled trial. MATERIALS AND METHODS: Self-administered,
      scenario-based survey. RESULTS: Sixty-two percent of eligible REBs (n = 83) and
      78% of eligible researchers (n = 124) completed the questionnaire. The REBs were 
      less comfortable endorsing alternative consent models when a substitute decision 
      maker was unavailable, including consent provided by (a) the intensivist involved
      with the trial (2.0% vs 15.3%; P = .014), (b) the intensivist not involved with
      the trial (10.0% vs 36.7%; P = .001), (c) 2 physicians (the intensivist and
      another consultant, neither of whom is involved with the trial) (18.0% vs 54.1%; 
      P < .001), and (d) 2 physicians involved neither with the trial nor the patient's
      care (10.2% vs 52.0%; P < .001). In similar circumstances, REBs were less
      comfortable approving both deferred (8.0% vs 43.3%; P < .001) and waived (4.1% vs
      22.4%; P = .005) consent. CONCLUSIONS: In this survey of scenarios involving
      low-risk critical care research, REBs were significantly more conservative in
      approving alternative consent models compared with investigators.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Duffett, Mark
AU  - Duffett M
AD  - McMaster Children's Hospital, Hamilton, Ontario, Canada. Electronic address:
      duffett@hhsc.ca.
FAU - Burns, Karen E
AU  - Burns KE
AD  - St. Michael's Hospital, Toronto, Ontario, Canada.
FAU - Kho, Michelle E
AU  - Kho ME
AD  - Johns Hopkins University, Baltimore, MD.
FAU - Lauzier, Francois
AU  - Lauzier F
AD  - Universite Laval, Quebec City, Quebec, Canada.
FAU - Meade, Maureen O
AU  - Meade MO
AD  - McMaster Children's Hospital, Hamilton, Ontario, Canada.
FAU - Arnold, Donald M
AU  - Arnold DM
AD  - McMaster Children's Hospital, Hamilton, Ontario, Canada.
FAU - Adhikari, Neill K J
AU  - Adhikari NKJ
AD  - Sunnybrook Health Sciences Centre and University of Toronto, Toronto, Ontario,
      Canada.
FAU - Lamontagne, Francois
AU  - Lamontagne F
AD  - Universite de Sherbrooke, Sherbrooke, Quebec, Canada.
FAU - Cook, Deborah J
AU  - Cook DJ
AD  - McMaster Children's Hospital, Hamilton, Ontario, Canada.
CN  - Academy of Critical CAre: Development, Evaluation, and MethodologY (ACCADEMY) and
      the Canadian Critical Care Trials group
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110303
PL  - United States
TA  - J Crit Care
JT  - Journal of critical care
JID - 8610642
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Canada
MH  - Critical Care/*ethics
MH  - Data Collection
MH  - *Ethics Committees, Research
MH  - Humans
MH  - Models, Theoretical
MH  - Randomized Controlled Trials as Topic/*ethics
MH  - Research Personnel/*psychology
MH  - Risk Assessment
MH  - Third-Party Consent/*ethics
EDAT- 2011/03/08 06:00
MHDA- 2012/02/09 06:00
CRDT- 2011/03/08 06:00
PHST- 2010/09/08 00:00 [received]
PHST- 2010/12/08 00:00 [revised]
PHST- 2010/12/12 00:00 [accepted]
PHST- 2011/03/08 06:00 [entrez]
PHST- 2011/03/08 06:00 [pubmed]
PHST- 2012/02/09 06:00 [medline]
AID - S0883-9441(10)00348-5 [pii]
AID - 10.1016/j.jcrc.2010.12.009 [doi]
PST - ppublish
SO  - J Crit Care. 2011 Oct;26(5):533.e11-533.e22. doi: 10.1016/j.jcrc.2010.12.009.
      Epub 2011 Mar 3.


PMID- 21376509
OWN - NLM
STAT- MEDLINE
DCOM- 20110719
LR  - 20161209
IS  - 2213-0276 (Electronic)
IS  - 0755-4982 (Linking)
VI  - 40
IP  - 5
DP  - 2011 May
TI  - [Distress during end-of-life: Ethical questions about sedation].
PG  - 486-92
LID - 10.1016/j.lpm.2011.01.012 [doi]
AB  - Distress and suffering are words currently used in the medical vocabulary, the
      first carrying a more acute and dramatic feature, while suffering is more
      subjective. They may concern the somatic, psychic, social, and spiritual domains,
      with interactions such as excrutiating and unrelieved pain causing psychological 
      distress. Distress during the end of life is induced by the threatening of an
      unavoidable death, more or less foreseen by the patient. It may correspond to an 
      existential distress, with loss of the meaning of life, and of the social role,
      along with metaphysical anxiety. Patient's next of kin and carers can also be
      involved by the distress, either by empathic transmission, or due to specific
      factors. Palliative care and anticipation should allow to prevent or relieve
      distress and suffering. This imply to ask for palliative care on due time, and to
      anticipate the foreseeable situations, trying meanwhile to identify the patient's
      preferences. Pharmacologic sedation is becoming a frequent practice during
      terminal phase of diseases, raising ethical questioning on its motives and aims. 
      Deep continuous sedation maintained until death may be viewed as a psychic and
      social euthanasia, ethically questionable, and should be foreseen only in case of
      intractable distress. A controlled and reversible sedation, when needed, should
      be preferred, always with the agreement of the patient or his/her proxy.
      Existential distress by itself should not justify a deep continuous sedation.
CI  - Copyright (c) 2011 Elsevier Masson SAS. All rights reserved.
FAU - Zittoun, Robert
AU  - Zittoun R
AD  - Hotel-Dieu, centre de diagnostic, 75004 Paris, France.
      robert.zittoun@club-internet.fr
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Detresse en fin de vie : questionnement ethique sur la sedation.
DEP - 20110303
PL  - France
TA  - Presse Med
JT  - Presse medicale (Paris, France : 1983)
JID - 8302490
SB  - IM
MH  - Deep Sedation/*ethics
MH  - Humans
MH  - Pain Management
MH  - Palliative Care/*ethics
MH  - Stress, Psychological/therapy
MH  - Terminal Care/*ethics
EDAT- 2011/03/08 06:00
MHDA- 2011/07/20 06:00
CRDT- 2011/03/08 06:00
PHST- 2010/12/08 00:00 [received]
PHST- 2011/01/13 00:00 [revised]
PHST- 2011/01/18 00:00 [accepted]
PHST- 2011/03/08 06:00 [entrez]
PHST- 2011/03/08 06:00 [pubmed]
PHST- 2011/07/20 06:00 [medline]
AID - S0755-4982(11)00064-9 [pii]
AID - 10.1016/j.lpm.2011.01.012 [doi]
PST - ppublish
SO  - Presse Med. 2011 May;40(5):486-92. doi: 10.1016/j.lpm.2011.01.012. Epub 2011 Mar 
      3.


PMID- 21376315
OWN - NLM
STAT- MEDLINE
DCOM- 20120113
LR  - 20111010
IS  - 1879-0267 (Electronic)
IS  - 0020-1383 (Linking)
VI  - 42
IP  - 10
DP  - 2011 Oct
TI  - Re-use of explanted osteosynthesis devices: a reliable and inexpensive
      reprocessing protocol.
PG  - 1101-6
LID - 10.1016/j.injury.2011.02.006 [doi]
AB  - INTRODUCTION: Orthopaedic surgical treatments emphasizing immobilization using
      open reduction and internal fixation with osteosynthesis devices are widely
      accepted for their efficacy in treating complex fractures and reducing permanent 
      musculoskeletal deformity. However, such treatments are profoundly underutilized 
      in low- and middle-income countries (LMIC), partially due to inadequate
      availability of the costly osteosynthesis devices. Orthopaedic surgeons in some
      LMIC regularly re-use osteosynthesis devices in an effort to meet treatment
      demands, even though such devices typically are regulated for single-use only.
      The purpose of this study is to report a reprocessing protocol applied to
      explanted osteosynthesis devices obtained at a leading trauma care hospital.
      METHODS: Explanted osteosynthesis devices were identified through a Register of
      Explanted Orthopaedic Prostheses. Guidelines to handle ethical issues were
      approved by the local Ethical Committee and informed patient consent was obtained
      at the time of explant surgery. Primary acceptance criteria were established and 
      applied to osteosynthesis devices explanted between 2005 and 2008. A rigorous
      protocol for conducting decontamination and visual inspection based on specific
      screening criteria was implemented using simple equipment that is readily
      available in LMIC. RESULTS: A total of 2050 osteosynthesis devices, including a
      large variety of plates, screws and staples, were reprocessed using the
      decontamination and inspection protocols. The acceptance rate was 66%. Estimated 
      labour time and implementation time of the protocol to reprocess a typical
      osteosynthesis unit (1 plate and 5 screws) was 25 min, with an estimated fixed
      cost (in Italy) of euro10 per unit for implementing the protocol, plus an
      additional euro5 for final sterilization at the end-user hospital site.
      DISCUSSION: This study was motivated by the treatment demands encountered by
      orthopaedic surgeons providing medical treatment in several different LMIC and
      their need for access to basic osteosynthesis devices. The rigorous
      decontamination protocol and generalized inspection criteria proved useful for
      efficiently screening a large volume of devices. Given that re-used
      osteosynthesis devices can yield satisfactory results, this study addresses
      potential complications of re-used devices and valid concerns that relate to
      patient safety. Implementing this defined reprocessing protocol into existing
      re-use practises in LMIC helps to limit the risks of inadequate sterilization and
      structural failure without adding additional risks to patients receiving re-used 
      devices.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Danesi, Valentina
AU  - Danesi V
AD  - Medical Technology Lab, Rizzoli Orthopaedic Institute, Bologna, Italy.
      vdanesi@tecno.ior.it
FAU - Cristofolini, Luca
AU  - Cristofolini L
FAU - Stea, Susanna
AU  - Stea S
FAU - Traina, Francesco
AU  - Traina F
FAU - Beraudi, Alina
AU  - Beraudi A
FAU - Tersi, Luca
AU  - Tersi L
FAU - Harman, Melinda
AU  - Harman M
FAU - Viceconti, Marco
AU  - Viceconti M
LA  - eng
PT  - Journal Article
DEP - 20110304
PL  - Netherlands
TA  - Injury
JT  - Injury
JID - 0226040
SB  - IM
MH  - Africa South of the Sahara
MH  - Decontamination/economics/methods/standards
MH  - Developing Countries
MH  - Equipment Contamination/prevention & control
MH  - Equipment Reuse/economics/standards
MH  - Equipment Safety/economics/standards
MH  - Fracture Fixation, Internal/economics/*instrumentation/standards
MH  - Guidelines as Topic
MH  - Humans
MH  - Internal Fixators/economics/standards/*supply & distribution
MH  - Recycling/methods
MH  - Sterilization/economics/methods/standards
EDAT- 2011/03/08 06:00
MHDA- 2012/01/14 06:00
CRDT- 2011/03/08 06:00
PHST- 2010/10/26 00:00 [received]
PHST- 2011/01/31 00:00 [revised]
PHST- 2011/02/08 00:00 [accepted]
PHST- 2011/03/08 06:00 [entrez]
PHST- 2011/03/08 06:00 [pubmed]
PHST- 2012/01/14 06:00 [medline]
AID - S0020-1383(11)00070-2 [pii]
AID - 10.1016/j.injury.2011.02.006 [doi]
PST - ppublish
SO  - Injury. 2011 Oct;42(10):1101-6. doi: 10.1016/j.injury.2011.02.006. Epub 2011 Mar 
      4.


PMID- 21376203
OWN - NLM
STAT- MEDLINE
DCOM- 20110705
LR  - 20220330
IS  - 1531-5037 (Electronic)
IS  - 0022-3468 (Linking)
VI  - 46
IP  - 3
DP  - 2011 Mar
TI  - Online hypospadias support group data analysis.
PG  - 520-4
LID - 10.1016/j.jpedsurg.2010.08.017 [doi]
AB  - BACKGROUND: Although hypospadias is the most common malformation of the penis,
      this condition is virtually unknown to the general population. This lack of
      information may lead to psychological distress to both parents and patients. In
      this study the content of an Internet-based hypospadias support group is
      analyzed. MATERIALS AND METHODS: All comments and postings made by members of an 
      online support group between 2001 and 2008 were analyzed. No personalized data
      were used for evaluation. RESULTS: At the end of 2008, the group consisted of 535
      members. In the study period, 3050 postings were published. Major issues
      discussed in the group were (a) medical questions, exchange of medical knowledge,
      experience, and history; (b) psychological, ethical, and philosophical aspects;
      (c) practical questions and recommendations; (d) recommendations for surgeons;
      and (e) hypospadias in adults. CONCLUSIONS: Online hypospadias support groups
      play an important role in how parents and patients cope with the condition.
      Surgeons dealing with hypospadias should be aware of the importance of
      Internet-based information in the field of hypospadias. They may benefit from the
      valuable feedback information from patients and parents to improve their practice
      and outcome.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Springer, Alexander
AU  - Springer A
AD  - Department of Pediatric Surgery, Medical University of Vienna, Vienna, Austria.
      alexander.springer@meduniwien.ac.at
FAU - Reck, Carlos A
AU  - Reck CA
FAU - Huber, Christiane
AU  - Huber C
FAU - Horcher, Ernst
AU  - Horcher E
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pediatr Surg
JT  - Journal of pediatric surgery
JID - 0052631
SB  - IM
MH  - Adult
MH  - *Bibliometrics
MH  - Child
MH  - Female
MH  - Humans
MH  - *Hypospadias/psychology
MH  - Internet
MH  - Male
MH  - Parents/psychology
MH  - Patients/psychology
MH  - Self Concept
MH  - *Self-Help Groups/statistics & numerical data
MH  - Social Support
EDAT- 2011/03/08 06:00
MHDA- 2011/07/06 06:00
CRDT- 2011/03/08 06:00
PHST- 2010/04/07 00:00 [received]
PHST- 2010/08/10 00:00 [revised]
PHST- 2010/08/11 00:00 [accepted]
PHST- 2011/03/08 06:00 [entrez]
PHST- 2011/03/08 06:00 [pubmed]
PHST- 2011/07/06 06:00 [medline]
AID - S0022-3468(10)00692-5 [pii]
AID - 10.1016/j.jpedsurg.2010.08.017 [doi]
PST - ppublish
SO  - J Pediatr Surg. 2011 Mar;46(3):520-4. doi: 10.1016/j.jpedsurg.2010.08.017.


PMID- 21376119
OWN - NLM
STAT- MEDLINE
DCOM- 20110802
LR  - 20151119
IS  - 1873-2518 (Electronic)
IS  - 0264-410X (Linking)
VI  - 29
IP  - 17
DP  - 2011 Apr 12
TI  - Public engagement on ethical principles in allocating scarce resources during an 
      influenza pandemic.
PG  - 3111-7
LID - 10.1016/j.vaccine.2011.02.032 [doi]
AB  - OBJECTIVES: To investigate the views of students, support staff and academic
      staff at the University of Alberta in Edmonton, Canada on the allocation of
      scarce resources during an influenza pandemic to discover if there were any
      shared values. METHODS: A web-based questionnaire was circulated to students,
      support staff and academic staff asking them how they would rank the priority of 
      eleven different groups for access to scarce resources. They were also asked to
      select one of seven priority access plans. RESULTS: The highest priority was
      given to health care workers by 89% of respondents, closely followed by emergency
      workers (85%). Only 12.7% of respondents gave politicians high priority.
      Respondents favored the "Save the most lives" priority access (39.9%) (N=5220).
      CONCLUSION: Current policies in place for the allocation of scarce resources
      during an influenza pandemic may not properly reflect the views of the general
      public. Further public consultation should be undertaken in order to uncover how 
      they would allocate scarce resources.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Bailey, Tracey M
AU  - Bailey TM
AD  - Health Law Institute, Faculty of Law, University of Alberta, Edmonton, Alberta,
      Canada T6G 2H5. tbailey@law.ualberta.ca
FAU - Haines, Christina
AU  - Haines C
FAU - Rosychuk, Rhonda J
AU  - Rosychuk RJ
FAU - Marrie, Thomas J
AU  - Marrie TJ
FAU - Yonge, Olive
AU  - Yonge O
FAU - Lake, Robert
AU  - Lake R
FAU - Herman, Ben
AU  - Herman B
FAU - Ammann, Mark
AU  - Ammann M
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110302
PL  - Netherlands
TA  - Vaccine
JT  - Vaccine
JID - 8406899
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alberta
MH  - Child
MH  - Child, Preschool
MH  - Disaster Planning
MH  - Female
MH  - Health Care Rationing/*ethics
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Influenza, Human/diagnosis/drug therapy/*epidemiology/*prevention & control
MH  - Male
MH  - Middle Aged
MH  - Pandemics/*prevention & control
MH  - Surveys and Questionnaires
MH  - Universities
MH  - Young Adult
EDAT- 2011/03/08 06:00
MHDA- 2011/08/04 06:00
CRDT- 2011/03/08 06:00
PHST- 2009/11/17 00:00 [received]
PHST- 2011/02/07 00:00 [revised]
PHST- 2011/02/13 00:00 [accepted]
PHST- 2011/03/08 06:00 [entrez]
PHST- 2011/03/08 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
AID - S0264-410X(11)00245-3 [pii]
AID - 10.1016/j.vaccine.2011.02.032 [doi]
PST - ppublish
SO  - Vaccine. 2011 Apr 12;29(17):3111-7. doi: 10.1016/j.vaccine.2011.02.032. Epub 2011
      Mar 2.


PMID- 21375762
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20211020
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 12
DP  - 2011 Mar 5
TI  - Prevention of hypertension in patients with pre-hypertension: protocol for the
      PREVER-prevention trial.
PG  - 65
LID - 10.1186/1745-6215-12-65 [doi]
AB  - BACKGROUND: Blood pressure (BP) within pre-hypertensive levels confers higher
      cardiovascular risk and is an intermediate stage for full hypertension, which
      develops in an annual rate of 7 out of 100 individuals with 40 to 50 years of
      age. Non-drug interventions to prevent hypertension have had low effectiveness.
      In individuals with previous cardiovascular disease or diabetes, the use of
      BP-lowering agents reduces the incidence of major cardiovascular events. In the
      absence of higher baseline risk, the use of BP agents reduces the incidence of
      hypertension. The PREVER-prevention trial aims to investigate the efficacy,
      safety and feasibility of a population-based intervention to prevent the
      incidence of hypertension and the development of target-organ damage. METHODS:
      This is a randomized, double-blind, placebo-controlled clinical trial, with
      participants aged 30 to 70 years, with pre-hypertension. The trial arms will be
      chlorthalidone 12.5 mg plus amiloride 2.5 mg or identical placebo. The primary
      outcomes will be the incidence of hypertension, adverse events and development or
      worsening of microalbuminuria and of left ventricular hypertrophy in the EKG. The
      secondary outcomes will be fatal or non-fatal cardiovascular events: myocardial
      infarction, stroke, heart failure, evidence of new sub-clinical atherosclerosis, 
      and sudden death. The study will last 18 months. The sample size was calculated
      on the basis of an incidence of hypertension of 14% in the control group, a size 
      effect of 40%, power of 85% and P alpha of 5%, resulting in 625 participants per 
      group. The project was approved by the Ethics committee of each participating
      institution. DISCUSSION: The early use of blood pressure-lowering drugs,
      particularly diuretics, which act on the main mechanism of blood pressure rising 
      with age, may prevent cardiovascular events and the incidence of hypertension in 
      individuals with hypertension. If this intervention shows to be effective and
      safe in a population-based perspective, it could be the basis for an innovative
      public health program to prevent hypertension in Brazil. TRIAL REGISTRATION:
      Clinical Trials NCT00970931.
FAU - Fuchs, Flavio D
AU  - Fuchs FD
AD  - Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, 
      Porto Alegre, Brazil. ffuchs@hcpa.ufrgs.br
FAU - Fuchs, Sandra C
AU  - Fuchs SC
FAU - Moreira, Leila B
AU  - Moreira LB
FAU - Gus, Miguel
AU  - Gus M
FAU - Nobrega, Antonio C
AU  - Nobrega AC
FAU - Poli-de-Figueiredo, Carlos E
AU  - Poli-de-Figueiredo CE
FAU - Mion, Decio
AU  - Mion D
FAU - Bortoloto, Luiz
AU  - Bortoloto L
FAU - Consolim-Colombo, Fernanda
AU  - Consolim-Colombo F
FAU - Nobre, Fernando
AU  - Nobre F
FAU - Coelho, Eduardo Barbosa
AU  - Coelho EB
FAU - Vilela-Martin, Jose F
AU  - Vilela-Martin JF
FAU - Moreno, Heitor Jr
AU  - Moreno H Jr
FAU - Cesarino, Evandro Jose
AU  - Cesarino EJ
FAU - Franco, Roberto
AU  - Franco R
FAU - Brandao, Andrea Araujo
AU  - Brandao AA
FAU - de Sousa, Marcos R
AU  - de Sousa MR
FAU - Ribeiro, Antonio Luiz Pinho
AU  - Ribeiro AL
FAU - Jardim, Paulo Cesar
AU  - Jardim PC
FAU - Neto, Abrahao Afiune
AU  - Neto AA
FAU - Scala, Luiz Cesar N
AU  - Scala LC
FAU - Mota, Marco
AU  - Mota M
FAU - Chaves, Hilton
AU  - Chaves H
FAU - Alves, Joao Guilherme
AU  - Alves JG
FAU - Filho, Dario C Sobral
AU  - Filho DC
FAU - Pereira e Silva, Ricardo
AU  - Pereira e Silva R
FAU - Neto, Jose A Figueiredo
AU  - Neto JA
FAU - Irigoyen, Maria Claudia
AU  - Irigoyen MC
FAU - Castro, Iran
AU  - Castro I
FAU - Steffens, Andre Avelino
AU  - Steffens AA
FAU - Schlatter, Rosane
AU  - Schlatter R
FAU - de Mello, Renato Bandeira
AU  - de Mello RB
FAU - Mosele, Francisca
AU  - Mosele F
FAU - Ghizzoni, Flavia
AU  - Ghizzoni F
FAU - Berwanger, Otavio
AU  - Berwanger O
LA  - eng
SI  - ClinicalTrials.gov/NCT00970931
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110305
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Diuretics)
RN  - 0 (Drug Combinations)
RN  - 7DZO8EB0Z3 (Amiloride)
RN  - Q0MQD1073Q (Chlorthalidone)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Amiloride/*therapeutic use
MH  - Antihypertensive Agents/*therapeutic use
MH  - Blood Pressure/drug effects
MH  - Brazil
MH  - Chlorthalidone/*therapeutic use
MH  - Diuretics/*therapeutic use
MH  - Double-Blind Method
MH  - Drug Combinations
MH  - Female
MH  - Humans
MH  - Hypertension/etiology/physiopathology/*therapy
MH  - Male
MH  - Middle Aged
MH  - Placebo Effect
MH  - Prehypertension/complications/*drug therapy/physiopathology
MH  - *Research Design
MH  - Treatment Outcome
PMC - PMC3059277
EDAT- 2011/03/08 06:00
MHDA- 2011/06/29 06:00
CRDT- 2011/03/08 06:00
PHST- 2010/12/08 00:00 [received]
PHST- 2011/03/05 00:00 [accepted]
PHST- 2011/03/08 06:00 [entrez]
PHST- 2011/03/08 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
AID - 1745-6215-12-65 [pii]
AID - 10.1186/1745-6215-12-65 [doi]
PST - epublish
SO  - Trials. 2011 Mar 5;12:65. doi: 10.1186/1745-6215-12-65.


PMID- 21375747
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1472-684X (Electronic)
IS  - 1472-684X (Linking)
VI  - 10
DP  - 2011 Mar 4
TI  - The perspectives of clinical staff and bereaved informal care-givers on the use
      of continuous sedation until death for cancer patients: The study protocol of the
      UNBIASED study.
PG  - 5
LID - 10.1186/1472-684X-10-5 [doi]
AB  - BACKGROUND: A significant minority of dying people experience refractory symptoms
      or extreme distress unresponsive to conventional therapies. In such
      circumstances, sedation may be used to decrease or remove consciousness until
      death occurs. This practice is described in a variety of ways, including:
      'palliative sedation', 'terminal sedation', 'continuous deep sedation until
      death', 'proportionate sedation' or 'palliative sedation to unconsciousness'.
      Surveys show large unexplained variation in incidence of sedation at the end of
      life across countries and care settings and there are ethical concerns about the 
      use, intentions, risks and significance of the practice in palliative care. There
      are also questions about how to explain international variation in the use of the
      practice. This protocol relates to the UNBIASED study (UK Netherlands Belgium
      International Sedation Study), which comprises three linked studies with separate
      funding sources in the UK, Belgium and the Netherlands. The aims of the study are
      to explore decision-making surrounding the application of continuous sedation
      until death in contemporary clinical practice, and to understand the experiences 
      of clinical staff and decedents' informal care-givers of the use of continuous
      sedation until death and their perceptions of its contribution to the dying
      process. The UNBIASED study is part of the European Association for Palliative
      Care Research Network. METHODS/DESIGN: To realize the study aims, a two-phase
      study has been designed. The study settings include: the domestic home, hospital 
      and expert palliative care sites. Phase 1 consists of: a) focus groups with
      health care staff and bereaved informal care-givers; and b) a preliminary case
      notes review to study the range of sedation therapy provided at the end of life
      to cancer patients who died within a 12 week period. Phase 2 employs qualitative 
      methods to develop 30 patient-centred case studies in each country. These involve
      interviews with staff and informal care-givers closely involved in the care of
      cancer patients who received continuous sedation until death. DISCUSSION: To our 
      knowledge, this is one of the few studies which seek to take a qualitative
      perspective on clinical decision making surrounding the use of continuous
      sedation until death and the only one which includes the perspectives of nurses, 
      physicians, as well as bereaved informal care-givers. It has several potential
      strengths, weaknesses, opportunities and threats associated with the specific
      design of the study, as well as with the sensitive nature of the topic and the
      different frameworks for ethical review in the participating countries.
FAU - Seymour, Jane
AU  - Seymour J
AD  - School of Nursing, Midwifery and Physiotherapy, University of Nottingham, Queen's
      Medical Centre, Derby Road, Nottingham, NG7 2UH, UK.
      jane.seymour@nottingham.ac.uk.
FAU - Rietjens, Judith
AU  - Rietjens J
FAU - Brown, Jayne
AU  - Brown J
FAU - van der Heide, Agnes
AU  - van der Heide A
FAU - Sterckx, Sigrid
AU  - Sterckx S
FAU - Deliens, Luc
AU  - Deliens L
CN  - UNBIASED study team
LA  - eng
PT  - Journal Article
DEP - 20110304
PL  - England
TA  - BMC Palliat Care
JT  - BMC palliative care
JID - 101088685
PMC - PMC3056823
EDAT- 2011/03/08 06:00
MHDA- 2011/03/08 06:01
CRDT- 2011/03/08 06:00
PHST- 2010/12/21 00:00 [received]
PHST- 2011/03/04 00:00 [accepted]
PHST- 2011/03/08 06:00 [entrez]
PHST- 2011/03/08 06:00 [pubmed]
PHST- 2011/03/08 06:01 [medline]
AID - 1472-684X-10-5 [pii]
AID - 10.1186/1472-684X-10-5 [doi]
PST - epublish
SO  - BMC Palliat Care. 2011 Mar 4;10:5. doi: 10.1186/1472-684X-10-5.


PMID- 21375745
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20220316
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 12
DP  - 2011 Mar 4
TI  - A trial on unruptured intracranial aneurysms (the TEAM trial): results, lessons
      from a failure and the necessity for clinical care trials.
PG  - 64
LID - 10.1186/1745-6215-12-64 [doi]
AB  - The trial on endovascular management of unruptured intracranial aneurysms (TEAM),
      a prospective randomized trial comparing coiling and conservative management,
      initiated in September 2006, was stopped in June 2009 because of poor recruitment
      (80 patients). Aspects of the trial design that may have contributed to this
      failure are reviewed in the hope of identifying better ways to successfully
      complete this special type of pragmatic trial which seeks to test two strategies 
      that are in routine clinical use. Cultural, conceptual and bureaucratic hurdles
      and difficulties obstruct all trials. These obstacles are however particularly
      misplaced when the trial aims to identify what a good medical practice should be.
      A clean separation between research and practice, with diverging ethical and
      scientific requirements, has been enforced for decades, but it cannot work when
      care needs to be provided in the presence of pervasive uncertainty. Hence valid
      and robust scientific methods need to be legitimately re-integrated into clinical
      practice when reliable knowledge is in want. A special status should be reserved 
      for what we would call 'clinical care trials', if we are to practice in a
      transparent and prospective fashion a medicine that leads to demonstrably better 
      patient outcomes.
FAU - Raymond, Jean
AU  - Raymond J
AD  - Centre hospitalier de l'Universite de Montreal (CHUM), Notre-Dame Hospital,
      Department of Radiology, Montreal, Quebec, Canada. jean.raymond@umontreal.ca
FAU - Darsaut, Tim E
AU  - Darsaut TE
FAU - Molyneux, Andrew J
AU  - Molyneux AJ
CN  - TEAM collaborative Group
LA  - eng
GR  - 80799/CAPMC/ CIHR/Canada
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
DEP - 20110304
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
SB  - IM
MH  - *Early Termination of Clinical Trials
MH  - *Endovascular Procedures
MH  - Evidence-Based Medicine
MH  - Humans
MH  - Intracranial Aneurysm/*therapy
MH  - *Patient Selection
MH  - Prospective Studies
MH  - Treatment Outcome
PMC - PMC3060834
IR  - Moret J
FIR - Moret, Jacques
IR  - Berenstein A
FIR - Berenstein, Alejandro
IR  - Zeumer H
FIR - Zeumer, Herman
IR  - Fiehler J
FIR - Fiehler, Jens
IR  - Choi IS
FIR - Choi, In Sup
IR  - McDougall C
FIR - McDougall, Cameron
IR  - Rinkel GJ
FIR - Rinkel, Gabriel J E
IR  - Feng L
FIR - Feng, Ling
IR  - Spears J
FIR - Spears, Julian
IR  - Raymond J
FIR - Raymond, Jean
IR  - Molyneux A
FIR - Molyneux, Andrew
IR  - Johnston C
FIR - Johnston, Claiborne
IR  - Rouleau I
FIR - Rouleau, Isabelle
IR  - Fox AJ
FIR - Fox, Allan J
IR  - Collet JP
FIR - Collet, Jean-Paul
IR  - Lepage Y
FIR - Lepage, Yves
IR  - Gasparini A
FIR - Gasparini, Antonieta
IR  - Gevry G
FIR - Gevry, Guylaine
IR  - Klink R
FIR - Klink, Ruby
IR  - Loor M
FIR - Loor, Marcia
IR  - Picard L
FIR - Picard, Luc
IR  - Eliasziw M
FIR - Eliasziw, Michael
IR  - Lebrun LH
FIR - Lebrun, Louise-Helene
IR  - Winslow GR
FIR - Winslow, Gerald R
IR  - Hosinec MJ
FIR - Hosinec, M James
IR  - Strother C
FIR - Strother, Charles
IR  - Lindegaard KF
FIR - Lindegaard, Karl-Fredrik
IR  - Roy D
FIR - Roy, Daniel
IR  - Lanthier S
FIR - Lanthier, Sylvain
IR  - Cote R
FIR - Cote, Robert
IR  - Minuk J
FIR - Minuk, Jeffrey
IR  - Mackey A
FIR - Mackey, Ariane
IR  - Fox AJ
FIR - Fox, Allan J
IR  - Weill A
FIR - Weill, Alain
IR  - White P
FIR - White, Philip
IR  - Rouleau I
FIR - Rouleau, Isabelle
IR  - de Miquel MA
FIR - de Miquel, Maria Angeles
IR  - Pasco-Papon A
FIR - Pasco-Papon, A
IR  - Bonneville JF
FIR - Bonneville, J F
IR  - Courtheoux P
FIR - Courtheoux, P
IR  - Chabert E
FIR - Chabert, E
IR  - Tournade A
FIR - Tournade, A
IR  - Gaston A
FIR - Gaston, A
IR  - Blanc R
FIR - Blanc, R
IR  - Le Bas JF
FIR - Le Bas, J F
IR  - Pruvo JP
FIR - Pruvo, J P
IR  - Leclerc X
FIR - Leclerc, X
IR  - Chapot R
FIR - Chapot, R
IR  - Turjman F
FIR - Turjman, F
IR  - Lamy B
FIR - Lamy, B
IR  - Tahon F
FIR - Tahon, F
IR  - Bracard S
FIR - Bracard, S
IR  - Anxionnat R
FIR - Anxionnat, R
IR  - De Kersaint GA
FIR - De Kersaint, Gilly A
IR  - Desal H
FIR - Desal, H
IR  - Meder JF
FIR - Meder, J F
IR  - Trystram D
FIR - Trystram, D
IR  - Godon-Hardy S
FIR - Godon-Hardy, S
IR  - Moret J
FIR - Moret, J
IR  - Piotin M
FIR - Piotin, M
IR  - Spelle L
FIR - Spelle, L
IR  - Mounayer C
FIR - Mounayer, C
IR  - Zuber M
FIR - Zuber, M
IR  - Houdart E
FIR - Houdart, E
IR  - Biondi A
FIR - Biondi, A
IR  - Bonneville F
FIR - Bonneville, F
IR  - Jean B
FIR - Jean, B
IR  - Sourour N
FIR - Sourour, N
IR  - Chiras J
FIR - Chiras, J
IR  - Pierot L
FIR - Pierot, L
IR  - Gallas S
FIR - Gallas, S
IR  - Manera L
FIR - Manera, L
IR  - Rodesch G
FIR - Rodesch, G
IR  - Cognard C
FIR - Cognard, C
IR  - Januel AC
FIR - Januel, A C
IR  - Tall P
FIR - Tall, P
IR  - Herbreteau D
FIR - Herbreteau, D
IR  - Molyneux AJ
FIR - Molyneux, A J
IR  - Byrne J
FIR - Byrne, J
IR  - Kerr R
FIR - Kerr, R
IR  - Adams W
FIR - Adams, W
IR  - Lamin S
FIR - Lamin, S
IR  - Halpin S
FIR - Halpin, S
IR  - White P
FIR - White, P
IR  - Sellar R
FIR - Sellar, R
IR  - Chawda S
FIR - Chawda, S
IR  - Nahser H
FIR - Nahser, H
IR  - Shaw D
FIR - Shaw, D
IR  - Jeffree M
FIR - Jeffree, M
IR  - Grieve J
FIR - Grieve, J
IR  - Kitchen N
FIR - Kitchen, N
IR  - Gholkar A
FIR - Gholkar, A
IR  - Lenthall R
FIR - Lenthall, R
IR  - Patankar T
FIR - Patankar, T
IR  - Hughes D
FIR - Hughes, D
IR  - Laitt R
FIR - Laitt, R
IR  - Herwadkar A
FIR - Herwadkar, A
IR  - Millar J
FIR - Millar, J
IR  - Olney J
FIR - Olney, J
IR  - Raymond J
FIR - Raymond, J
IR  - Roy D
FIR - Roy, D
IR  - Guilbert F
FIR - Guilbert, F
IR  - Weill A
FIR - Weill, A
IR  - Tampieri D
FIR - Tampieri, D
IR  - Mohr G
FIR - Mohr, G
IR  - Milot G
FIR - Milot, G
IR  - Gariepy JL
FIR - Gariepy, J L
IR  - Redekop G
FIR - Redekop, G
IR  - Lum C
FIR - Lum, C
IR  - Silvaggio J
FIR - Silvaggio, J
IR  - Iancu D
FIR - Iancu, D
IR  - Marotta T
FIR - Marotta, T
IR  - Montanera W
FIR - Montanera, W
IR  - Chen M
FIR - Chen, M
IR  - Lee V
FIR - Lee, V
IR  - Temes R
FIR - Temes, R
IR  - Chaloupka J
FIR - Chaloupka, J
IR  - Hayakawa M
FIR - Hayakawa, M
IR  - Klucznik RP
FIR - Klucznik, R P
IR  - Kase C
FIR - Kase, C
IR  - Lau H
FIR - Lau, H
IR  - Berenstein A
FIR - Berenstein, A
IR  - Niimi Y
FIR - Niimi, Y
IR  - Gobin P
FIR - Gobin, P
IR  - Mangla S
FIR - Mangla, S
IR  - McDougall C
FIR - McDougall, C
IR  - Turk A
FIR - Turk, A
IR  - Tummala R
FIR - Tummala, R
IR  - Qureshi A
FIR - Qureshi, A
IR  - Von Kummer R
FIR - Von Kummer, R
IR  - Zeumer J
FIR - Zeumer, J
IR  - Fiehler H
FIR - Fiehler, H
IR  - Valvassori L
FIR - Valvassori, L
IR  - Boccardi E
FIR - Boccardi, E
IR  - Quillici L
FIR - Quillici, L
IR  - Bakke SJ
FIR - Bakke, S J
IR  - Kindergaard KF
FIR - Kindergaard, K F
IR  - Kobayashi A
FIR - Kobayashi, A
IR  - de Miquel MA
FIR - de Miquel, M A
IR  - Stefani M
FIR - Stefani, M
IR  - Szikora I
FIR - Szikora, I
IR  - Kulcsar Z
FIR - Kulcsar, Z
EDAT- 2011/03/08 06:00
MHDA- 2011/06/29 06:00
CRDT- 2011/03/08 06:00
PHST- 2010/10/25 00:00 [received]
PHST- 2011/03/04 00:00 [accepted]
PHST- 2011/03/08 06:00 [entrez]
PHST- 2011/03/08 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
AID - 1745-6215-12-64 [pii]
AID - 10.1186/1745-6215-12-64 [doi]
PST - epublish
SO  - Trials. 2011 Mar 4;12:64. doi: 10.1186/1745-6215-12-64.


PMID- 21375101
OWN - NLM
STAT- MEDLINE
DCOM- 20110322
LR  - 20190319
IS  - 0310-057X (Print)
IS  - 0310-057X (Linking)
VI  - 39
IP  - 1
DP  - 2011 Jan
TI  - End-of-life decisions in Hungarian intensive care units.
PG  - 116-21
AB  - The awareness of local practice of end-of-life decisions in accordance with the
      law and ethical principles is essential for intensive care physicians in all
      countries. The first step for the required social dialogue is to investigate
      local practice. We performed the first Hungarian survey with the aim of better
      understanding local practice in end-of-life decisions in intensive care units.
      Questionnaires were sent out electronically to 743 members of the Hungarian
      Society of Anaesthesiology and Intensive Care. Respecting anonymity, we have
      statistically evaluated 103 replies (response rate 13.8%) and compared the
      results to data from other European countries. The results show that the practice
      of intensive care physicians in Hungary is rather paternalistic. Intensive care
      physicians generally make their decisions alone (3.75/5 points) without
      considering the opinion of the patient (2.57/5 points), the relatives (2.14/5
      points) or other medical staff (2.37/5 points). Furthermore, they prefer not to
      start a form of treatment rather than to withdraw an ongoing one. Nevertheless,
      the frequency of end-of-life decisions (3 to 9% of intensive care unit patients) 
      made in Hungarian intensive care units is less than in other European countries. 
      End-of-life decisions are part of medical practice. Since the legal and ethical
      framework is unclear practice varies between locations and mostly depends on
      individual decisions rather than established protocols or guidance. For
      end-of-life decisions, self-determination must be supported and a dialogue must
      be established between lawmakers and physicians.
FAU - Zubek, L
AU  - Zubek L
AD  - Department ofAnaesthesiology and Intensive Therapy, Semmelweis University,
      Budapest, Hungary. lzubek@freemail.hu
FAU - Szabo, L
AU  - Szabo L
FAU - Dioszeghy, Cs
AU  - Dioszeghy C
FAU - Gal, J
AU  - Gal J
FAU - Elo, G
AU  - Elo G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Anaesth Intensive Care
JT  - Anaesthesia and intensive care
JID - 0342017
SB  - IM
MH  - Attitude of Health Personnel
MH  - Critical Care
MH  - *Decision Making
MH  - Europe
MH  - Female
MH  - Humans
MH  - Hungary
MH  - *Intensive Care Units
MH  - Male
MH  - Paternalism
MH  - Physician-Patient Relations
MH  - Practice Patterns, Physicians'/*statistics & numerical data
MH  - Sex Distribution
MH  - Surveys and Questionnaires
MH  - Terminal Care/*methods/statistics & numerical data
MH  - Withholding Treatment/*statistics & numerical data
EDAT- 2011/03/08 06:00
MHDA- 2011/03/23 06:00
CRDT- 2011/03/08 06:00
PHST- 2011/03/08 06:00 [entrez]
PHST- 2011/03/08 06:00 [pubmed]
PHST- 2011/03/23 06:00 [medline]
AID - 20100472 [pii]
AID - 10.1177/0310057X1103900119 [doi]
PST - ppublish
SO  - Anaesth Intensive Care. 2011 Jan;39(1):116-21. doi: 10.1177/0310057X1103900119.


PMID- 21373958
OWN - NLM
STAT- MEDLINE
DCOM- 20110823
LR  - 20211020
IS  - 1573-3599 (Electronic)
IS  - 1059-7700 (Linking)
VI  - 20
IP  - 3
DP  - 2011 Jun
TI  - Teaching about genetic testing issues in the undergraduate classroom: a case
      study.
PG  - 231-40
LID - 10.1007/s10897-011-9352-2 [doi]
AB  - Educating undergraduates about current genetic testing and genomics can involve
      novel and creative teaching practices. The higher education literature describes 
      numerous pedagogical approaches in the laboratory designed to engage science and 
      liberal arts students. Often these experiences involve students analyzing their
      own genes for various polymorphisms, some of which are associated with disease
      states such as an increased risk for developing cancer. While the literature
      acknowledges possible ethical ramifications of such laboratory exercises, authors
      do not present recommendations or rubrics for evaluating whether or not the
      testing is, in fact, ethical. In response, we developed a laboratory
      investigation and discussion which allowed undergraduate science students to
      explore current DNA manipulation techniques to isolate their p53 gene, followed
      by a dialogue probing the ethical implications of examining their sample for
      various polymorphisms. Students never conducted genotyping on their samples
      because of ethical concerns, so the discussion served to replace actual genetic
      testing in the class. A basic scientist led the laboratory portion of the
      assignment. A genetic counselor facilitated the discussion, which centered around
      existing ethical guidelines for clinical genetic testing and possible challenges 
      of human genotyping outside the medical setting. In their final papers, students 
      demonstrated an understanding of the practice guidelines established by the
      genetics community and acknowledged the ethical considerations inherent in p53
      genotyping. Given the burgeoning market for personalized medicine, teaching
      undergraduates about the psychosocial and ethical dimensions of human gene
      testing seems important and timely, and introduces an additional role genetic
      counselors can play in educating consumers about genomics.
FAU - Rogers, Jill Cellars
AU  - Rogers JC
AD  - Pre-health Advising, Wabash College, Crawfordsville, IN 47933-0352, USA.
      rogersji@wabash.edu
FAU - Taylor, Ann T S
AU  - Taylor AT
LA  - eng
PT  - Journal Article
DEP - 20110304
PL  - United States
TA  - J Genet Couns
JT  - Journal of genetic counseling
JID - 9206865
SB  - IM
MH  - California
MH  - Education/*methods
MH  - Ethics, Medical
MH  - Female
MH  - Genes, p53
MH  - *Genetic Testing
MH  - Humans
MH  - Male
MH  - Pedigree
MH  - Polymorphism, Genetic
MH  - *Universities
EDAT- 2011/03/05 06:00
MHDA- 2011/08/24 06:00
CRDT- 2011/03/05 06:00
PHST- 2010/09/21 00:00 [received]
PHST- 2011/01/14 00:00 [accepted]
PHST- 2011/03/05 06:00 [entrez]
PHST- 2011/03/05 06:00 [pubmed]
PHST- 2011/08/24 06:00 [medline]
AID - 10.1007/s10897-011-9352-2 [doi]
PST - ppublish
SO  - J Genet Couns. 2011 Jun;20(3):231-40. doi: 10.1007/s10897-011-9352-2. Epub 2011
      Mar 4.


PMID- 21373941
OWN - NLM
STAT- MEDLINE
DCOM- 20110922
LR  - 20211020
IS  - 1435-2451 (Electronic)
IS  - 1435-2443 (Linking)
VI  - 396
IP  - 4
DP  - 2011 Apr
TI  - Mesenchymal stem cells and progenitor cells in connective tissue engineering and 
      regenerative medicine: is there a future for transplantation?
PG  - 489-97
LID - 10.1007/s00423-011-0762-2 [doi]
AB  - PURPOSE: Transplantation surgery suffers from a shortage of donor organs
      worldwide. Cell injection and tissue engineering (TE), thus emerge as alternative
      therapy options. The purpose of this article is to review the progress of TE
      technology, focusing on mesenchymal stem cells (MSC) as a cell source for
      artificial functional tissue. RESULTS: MSC from many different sources can be
      minimally invasively harvested: peripheral blood, fat tissue, bone marrow,
      amniotic fluid, cord blood. In comparison to embryonic stem cells (ESC), there
      are no ethical concerns; MSC can be extracted from autologous or allogenic tissue
      and cause an immune modulatory effect by suppressing the graft-versus-host
      reaction (GvHD). Furthermore, MSC do not develop into teratomas when
      transplanted, a consequence observed with ESC and iPS cells. CONCLUSION: MSC as
      multipotent cells are capable of differentiating into mesodermal and
      non-mesodermal lineages. However, further studies must be performed to elucidate 
      the differentiation capacity of MSC from different sources, and to understand the
      involved pathways and processes. Already, MSC have been successfully applied in
      clinical trials, e.g., to heal large bone defects, cartilage lesions, spinal cord
      injuries, cardiovascular diseases, hematological pathologies, osteogenesis
      imperfecta, and GvHD. A detailed understanding of the behavior and homing of MSC 
      is desirable to enlarge the clinical application spectrum of MSC towards the in
      vitro generation of functional tissue for implantation, for example, resilient
      cartilage, contractile myocardial replacement tissue, and bioartificial heart
      valves.
FAU - Hilfiker, Andres
AU  - Hilfiker A
AD  - Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO),
      Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover, Germany.
      hilfiker.andres@mh-hannover.de
FAU - Kasper, Cornelia
AU  - Kasper C
FAU - Hass, Ralf
AU  - Hass R
FAU - Haverich, Axel
AU  - Haverich A
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110304
PL  - Germany
TA  - Langenbecks Arch Surg
JT  - Langenbeck's archives of surgery
JID - 9808285
SB  - IM
MH  - Connective Tissue/growth & development/transplantation
MH  - Connective Tissue Cells/cytology
MH  - Humans
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Mesenchymal Stem Cells/*physiology
MH  - *Regenerative Medicine
MH  - *Tissue Engineering
EDAT- 2011/03/05 06:00
MHDA- 2011/09/23 06:00
CRDT- 2011/03/05 06:00
PHST- 2011/01/17 00:00 [received]
PHST- 2011/02/21 00:00 [accepted]
PHST- 2011/03/05 06:00 [entrez]
PHST- 2011/03/05 06:00 [pubmed]
PHST- 2011/09/23 06:00 [medline]
AID - 10.1007/s00423-011-0762-2 [doi]
PST - ppublish
SO  - Langenbecks Arch Surg. 2011 Apr;396(4):489-97. doi: 10.1007/s00423-011-0762-2.
      Epub 2011 Mar 4.


PMID- 21373804
OWN - NLM
STAT- MEDLINE
DCOM- 20120430
LR  - 20211020
IS  - 0148-5598 (Print)
IS  - 0148-5598 (Linking)
VI  - 35
IP  - 5
DP  - 2011 Oct
TI  - A lightweight security scheme for wireless body area networks: design, energy
      evaluation and proposed microprocessor design.
PG  - 1289-98
LID - 10.1007/s10916-011-9669-2 [doi]
AB  - In order for wireless body area networks to meet widespread adoption, a number of
      security implications must be explored to promote and maintain fundamental
      medical ethical principles and social expectations. As a result, integration of
      security functionality to sensor nodes is required. Integrating security
      functionality to a wireless sensor node increases the size of the stored software
      program in program memory, the required time that the sensor's microprocessor
      needs to process the data and the wireless network traffic which is exchanged
      among sensors. This security overhead has dominant impact on the energy
      dissipation which is strongly related to the lifetime of the sensor, a critical
      aspect in wireless sensor network (WSN) technology. Strict definition of the
      security functionality, complete hardware model (microprocessor and radio), WBAN 
      topology and the structure of the medium access control (MAC) frame are required 
      for an accurate estimation of the energy that security introduces into the WBAN. 
      In this work, we define a lightweight security scheme for WBAN, we estimate the
      additional energy consumption that the security scheme introduces to WBAN based
      on commercial available off-the-shelf hardware components (microprocessor and
      radio), the network topology and the MAC frame. Furthermore, we propose a new
      microcontroller design in order to reduce the energy consumption of the system.
      Experimental results and comparisons with other works are given.
FAU - Selimis, Georgios
AU  - Selimis G
AD  - Holst Centre/IMEC, Eindhoven, The Netherlands. georgios.selimis@imec-nl.nl
FAU - Huang, Li
AU  - Huang L
FAU - Masse, Fabien
AU  - Masse F
FAU - Tsekoura, Ioanna
AU  - Tsekoura I
FAU - Ashouei, Maryam
AU  - Ashouei M
FAU - Catthoor, Francky
AU  - Catthoor F
FAU - Huisken, Jos
AU  - Huisken J
FAU - Stuyt, Jan
AU  - Stuyt J
FAU - Dolmans, Guido
AU  - Dolmans G
FAU - Penders, Julien
AU  - Penders J
FAU - De Groot, Harmke
AU  - De Groot H
LA  - eng
PT  - Journal Article
DEP - 20110305
PL  - United States
TA  - J Med Syst
JT  - Journal of medical systems
JID - 7806056
SB  - IM
MH  - Computer Communication Networks
MH  - Computer Security/*instrumentation
MH  - *Electricity
MH  - Equipment Design
MH  - Humans
MH  - *Microcomputers
MH  - Monitoring, Physiologic/*instrumentation
MH  - Telemetry/*instrumentation
EDAT- 2011/03/05 06:00
MHDA- 2012/05/01 06:00
CRDT- 2011/03/05 06:00
PHST- 2010/10/31 00:00 [received]
PHST- 2011/02/16 00:00 [accepted]
PHST- 2011/03/05 06:00 [entrez]
PHST- 2011/03/05 06:00 [pubmed]
PHST- 2012/05/01 06:00 [medline]
AID - 10.1007/s10916-011-9669-2 [doi]
PST - ppublish
SO  - J Med Syst. 2011 Oct;35(5):1289-98. doi: 10.1007/s10916-011-9669-2. Epub 2011 Mar
      5.


PMID- 21372556
OWN - NLM
STAT- MEDLINE
DCOM- 20111212
LR  - 20110810
IS  - 1421-9964 (Electronic)
IS  - 1015-3837 (Linking)
VI  - 30
IP  - 1
DP  - 2011
TI  - Ethical issues on pregnancy termination: impact of new imaging modalities.
PG  - 1-8
LID - 10.1159/000324540 [doi]
AB  - OBJECTIVE: To explicate the ontological statuses of both the fetus and neonate as
      a basis for clinical ethical judgments about the obligations of both physicians
      and pregnant women to protect the life and health of both the fetus and the
      neonate. METHODS: Despite drastic changes in perinatology, there is still a legal
      separation between fetuses and neonates. Neonatal status remains specific because
      of the prohibition of 'transgressing human life'. Nevertheless, the concept of a 
      'prenatal human being' recently emerged. While new technologies blur the
      fetus/neonate borderline, why is it still legal in many European countries to
      terminate a fetal life in the late stages of pregnancy? One might even support
      the idea that what is authorized before birth should also be after, thereby
      'fetalizing' neonates. RESULTS: The 'personalistic' approach is against this
      'fetalization', considering that terminating a neonate life is 'transgressive'.
      The 'utilitarian' model considers we cannot decide what is good for someone else,
      which justifies terminating the life of neonates who are not persons yet. A
      phenomenological view supports the ontological difference on our perceptions,
      differing whether we observe ultrasound fetal images or real neonatal pictures.
      CONCLUSION: This does not mean the weight of fetal images should be
      underestimated.
CI  - Copyright (c) 2011 S. Karger AG, Basel.
FAU - Gorincour, Guillaume
AU  - Gorincour G
AD  - Mediterranean Ethical Forum, EA 3783, Universite de la Mediterranee, La Timone
      Hospital, Marseille, France. Guillaume.GORINCOUR@ap-hm.fr
FAU - Tassy, Sebastien
AU  - Tassy S
FAU - Simeoni, Umberto
AU  - Simeoni U
FAU - Le Coz, Pierre
AU  - Le Coz P
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110303
PL  - Switzerland
TA  - Fetal Diagn Ther
JT  - Fetal diagnosis and therapy
JID - 9107463
SB  - IM
MH  - Abortion, Induced/*ethics
MH  - Female
MH  - *Fetus
MH  - Humans
MH  - *Infant, Newborn
MH  - Pregnancy
MH  - *Ultrasonography, Prenatal
EDAT- 2011/03/05 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/03/05 06:00
PHST- 2010/11/02 00:00 [received]
PHST- 2011/01/17 00:00 [accepted]
PHST- 2011/03/05 06:00 [entrez]
PHST- 2011/03/05 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 000324540 [pii]
AID - 10.1159/000324540 [doi]
PST - ppublish
SO  - Fetal Diagn Ther. 2011;30(1):1-8. doi: 10.1159/000324540. Epub 2011 Mar 3.


PMID- 21372535
OWN - NLM
STAT- MEDLINE
DCOM- 20110825
LR  - 20190724
IS  - 0031-6903 (Print)
IS  - 0031-6903 (Linking)
VI  - 131
IP  - 3
DP  - 2011 Mar
TI  - [History of the Nippon Shinyaku Institute for Botanical Research].
PG  - 395-400
AB  - Soon after its foundation in 1919, Nippon Shinyaku Co., Ltd began to develop the 
      domestic production of Santonin, an anthelmintic agent, which, until then, had
      been totally imported from Russia. In 1927, Artemisia maritima ssp. monogyna was 
      introduced from Europe and confirmed to contain Santonin. This European aster
      plant was named Mibu-yomogi after the place name of the headquarters of Nippon
      Shinyaku. In 1934, Yamashina Experimental Farm was founded to breed Mibu-yomogi
      cultivars of high quality as a plant material for Santonin production in Japan.
      In 1953, the Experimental Farm was reorganized into the Institute for Botanical
      Research for the continuous breeding of Santonin-containing aster plants and for 
      the development of any new medicines from medicinal plants. Through the breeding 
      of Santonin-containing aster plants, many cultivars including Yamashina No. 2
      from Mibu-yomogi, Penta-yomogi and Hexa-yomogi which were crosssed with
      Mibu-yomogi and A. kurramensis, were bred. Furthermore, we still have four
      ethical drug products originated from medicinal plants. Since 1994, the Institute
      has become a botanical garden in order to maintain, develop and exhibit the plant
      collection and for the cultivation studies of rare plants.
FAU - Yamaura, Takao
AU  - Yamaura T
AD  - The Nippon Shinyaku Institute for Botanical Research, Nippon Shinyaku Co., Ltd.
      t.yamaura@po.nippon-shinyaku.co.jp
LA  - jpn
PT  - English Abstract
PT  - Historical Article
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Yakugaku Zasshi
JT  - Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
JID - 0413613
RN  - 1VL8J38ERO (Santonin)
SB  - IM
MH  - *Academies and Institutes/history/trends
MH  - Aster Plant
MH  - *Botany/history/trends
MH  - Breeding
MH  - *Drug Discovery/history/trends
MH  - *Drug Industry/history/trends
MH  - Endangered Species
MH  - History, 20th Century
MH  - Japan
MH  - Plants, Medicinal
MH  - Santonin
MH  - Social Responsibility
EDAT- 2011/03/05 06:00
MHDA- 2011/08/27 06:00
CRDT- 2011/03/05 06:00
PHST- 2011/03/05 06:00 [entrez]
PHST- 2011/03/05 06:00 [pubmed]
PHST- 2011/08/27 06:00 [medline]
AID - JST.JSTAGE/yakushi/131.395 [pii]
AID - 10.1248/yakushi.131.395 [doi]
PST - ppublish
SO  - Yakugaku Zasshi. 2011 Mar;131(3):395-400. doi: 10.1248/yakushi.131.395.


PMID- 21372245
OWN - NLM
STAT- MEDLINE
DCOM- 20110715
LR  - 20161125
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 2
DP  - 2011 Mar
TI  - Reflections on a grounded theory and nursing ethics workshop.
PG  - 272-3
LID - 10.1177/0969733010395699 [doi]
FAU - King, Linda
AU  - King L
AD  - Kingston University and St George's University of London, UK.
FAU - Wood, Julia
AU  - Wood J
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - *Ethical Theory
MH  - Ethicists
MH  - Ethics, Nursing/*education
MH  - Humans
MH  - Nurse's Role
MH  - Nursing Care/*ethics
MH  - *Nursing Theory
MH  - *Philosophy, Nursing
MH  - United Kingdom
EDAT- 2011/03/05 06:00
MHDA- 2011/07/16 06:00
CRDT- 2011/03/05 06:00
PHST- 2011/03/05 06:00 [entrez]
PHST- 2011/03/05 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
AID - 18/2/272 [pii]
AID - 10.1177/0969733010395699 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Mar;18(2):272-3. doi: 10.1177/0969733010395699.


PMID- 21372239
OWN - NLM
STAT- MEDLINE
DCOM- 20110715
LR  - 20110304
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 2
DP  - 2011 Mar
TI  - Care transformations: attentiveness, professional ethics and thoughts towards
      differentiation.
PG  - 258-61
LID - 10.1177/0969733010396818 [doi]
FAU - Kohlen, Helen
AU  - Kohlen H
AD  - University of Vallendar, Germany. kohlenh@pthv.de
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
CON - Nurs Ethics. 2011 Mar;18(2):161-73. PMID: 21372229
CON - Nurs Ethics. 2011 Mar;18(2):174-83. PMID: 21372230
CON - Nurs Ethics. 2011 Mar;18(2):184-91. PMID: 21372231
CON - Nurs Ethics. 2011 Mar;18(2):192-200. PMID: 21372232
CON - Nurs Ethics. 2011 Mar;18(2):209-16. PMID: 21372234
CON - Nurs Ethics. 2011 Mar;18(2):217-31. PMID: 21372235
MH  - Empathy/*ethics
MH  - Ethical Theory
MH  - *Ethics, Nursing
MH  - Humans
MH  - Morals
MH  - *Nurse's Role
MH  - Nurse-Patient Relations/ethics
MH  - Nursing Care/*ethics
MH  - Principle-Based Ethics
EDAT- 2011/03/05 06:00
MHDA- 2011/07/16 06:00
CRDT- 2011/03/05 06:00
PHST- 2011/03/05 06:00 [entrez]
PHST- 2011/03/05 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
AID - 18/2/258 [pii]
AID - 10.1177/0969733010396818 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Mar;18(2):258-61. doi: 10.1177/0969733010396818.


PMID- 21372237
OWN - NLM
STAT- MEDLINE
DCOM- 20110715
LR  - 20110304
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 2
DP  - 2011 Mar
TI  - Commentary: Care tactics--arguments, absences and assumptions in relational
      ethics.
PG  - 243-54; discussion 262-71
LID - 10.1177/0969733010393070 [doi]
FAU - Paley, John
AU  - Paley J
AD  - Department of Nursing and Midwifery, University of Stirling, Stirling FK9 4LA,
      Scotland, UK. j.h.paley@stir.ac.uk
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
CON - Nurs Ethics. 2011 Mar;18(2):149-60. PMID: 21372228
CON - Nurs Ethics. 2011 Mar;18(2):161-73. PMID: 21372229
CON - Nurs Ethics. 2011 Mar;18(2):174-83. PMID: 21372230
CON - Nurs Ethics. 2011 Mar;18(2):192-200. PMID: 21372232
CON - Nurs Ethics. 2011 Mar;18(2):209-16. PMID: 21372234
CON - Nurs Ethics. 2011 Mar;18(2):217-31. PMID: 21372235
CON - Nurs Ethics. 2011 Mar;18(2):232-42. PMID: 21372236
MH  - Empathy/ethics
MH  - *Ethical Theory
MH  - Ethics, Nursing
MH  - Evidence-Based Nursing
MH  - Humans
MH  - Moral Obligations
MH  - Morals
MH  - *Nurse's Role
MH  - Nurse-Patient Relations/*ethics
MH  - Nursing Care/*ethics
MH  - *Philosophy, Nursing
MH  - *Principle-Based Ethics
EDAT- 2011/03/05 06:00
MHDA- 2011/07/16 06:00
CRDT- 2011/03/05 06:00
PHST- 2011/03/05 06:00 [entrez]
PHST- 2011/03/05 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
AID - 18/2/243 [pii]
AID - 10.1177/0969733010393070 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Mar;18(2):243-54; discussion 262-71. doi:
      10.1177/0969733010393070.


PMID- 21372236
OWN - NLM
STAT- MEDLINE
DCOM- 20110715
LR  - 20110304
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 2
DP  - 2011 Mar
TI  - Researching lived experience in health care: significance for care ethics.
PG  - 232-42
LID - 10.1177/0969733010389253 [doi]
AB  - The aim of this article is to demonstrate the usefulness of qualitative research 
      for studying the ethics of care, bringing to light the lived experience of health
      care recipients, together with the importance of methods that allow
      reconstruction of the processes underlying this lived experience. Lived
      experiences of families being approached for organ donation, parents facing the
      imminent death of their child and patients being treated using stem cell
      transplantation are used to illustrate how ethical principles are differentiated,
      modified or contradicted by the narrative context of persons concerned. The
      integration of empirical data into ethics will help caregivers in their ethical
      decision making and may enrich care ethics as a narrative and interpretative
      field.
FAU - Dierckx de Casterle, Bernadette
AU  - Dierckx de Casterle B
AD  - Centre of Health Services and Nursing Research, Faculty of Medicine, Catholic
      University of Leuven, Kapucijnenvoer 35 blok, 3000 Leuven, Belgium.
      bernadette.dierckxdecasterle@med.kuleuven.be
FAU - Verhaeghe, Sofie T L
AU  - Verhaeghe ST
FAU - Kars, Marijke C
AU  - Kars MC
FAU - Coolbrandt, Annemarie
AU  - Coolbrandt A
FAU - Stevens, Marleen
AU  - Stevens M
FAU - Stubbe, Maaike
AU  - Stubbe M
FAU - Deweirdt, Nathalie
AU  - Deweirdt N
FAU - Vincke, Jeroen
AU  - Vincke J
FAU - Grypdonck, Maria
AU  - Grypdonck M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
CIN - Nurs Ethics. 2011 Mar;18(2):243-54; discussion 262-71. PMID: 21372237
MH  - Empathy/ethics
MH  - *Ethical Theory
MH  - Ethics, Nursing
MH  - Humans
MH  - Moral Obligations
MH  - Morals
MH  - *Nurse's Role
MH  - Nurse-Patient Relations/*ethics
MH  - Nursing Care/*ethics
MH  - *Philosophy, Nursing
MH  - Principle-Based Ethics
EDAT- 2011/03/05 06:00
MHDA- 2011/07/16 06:00
CRDT- 2011/03/05 06:00
PHST- 2011/03/05 06:00 [entrez]
PHST- 2011/03/05 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
AID - 18/2/232 [pii]
AID - 10.1177/0969733010389253 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Mar;18(2):232-42. doi: 10.1177/0969733010389253.


PMID- 21372234
OWN - NLM
STAT- MEDLINE
DCOM- 20110715
LR  - 20110304
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 2
DP  - 2011 Mar
TI  - Mature care in professional relationships and health care prioritizations.
PG  - 209-16
LID - 10.1177/0969733010389257 [doi]
AB  - This article addresses some ambiguities and normative problems with the concept
      of mature care in professional relationships and in health care priorities.
      Mature care has recently been introduced in the literature on care ethics as an
      alternative to prevailing altruistic conceptions of care. The essence of mature
      care is an emphasis on reciprocity, where the mature agent has the ability to
      balance the concerns of self with those of others and act from a principle of not
      causing harm. Our basic claim is that the prevailing concept of mature care does 
      not capture the real nature of professional relationships and role obligations in
      health care. As the focus of attention in professional care is and must be the
      patient's particular medical and care needs, such care must principally be
      altruistic. Furthermore, we argue that mature care cannot adequately address
      moral conflict in health care without accepting some more principle-based
      approaches and a richer notion of partiality.
FAU - Nordhaug, Marita
AU  - Nordhaug M
AD  - Centre for the Study of Professions, Oslo University College, PO Box 4, St Olavs 
      Plass, N-0130 Oslo, Norway. marita.nordhaug@hio.no
FAU - Nortvedt, Per
AU  - Nortvedt P
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
CIN - Nurs Ethics. 2011 Mar;18(2):243-54; discussion 262-71. PMID: 21372237
CIN - Nurs Ethics. 2011 Mar;18(2):255-7. PMID: 21372238
CIN - Nurs Ethics. 2011 Mar;18(2):258-61. PMID: 21372239
MH  - *Altruism
MH  - Attitude of Health Personnel
MH  - Empathy/ethics
MH  - Ethical Theory
MH  - *Ethics, Medical
MH  - Humans
MH  - Morals
MH  - Patient Care/*ethics
MH  - Patient-Centered Care/ethics
MH  - *Principle-Based Ethics
MH  - *Professional Role
MH  - Professional-Patient Relations/*ethics
EDAT- 2011/03/05 06:00
MHDA- 2011/07/16 06:00
CRDT- 2011/03/05 06:00
PHST- 2011/03/05 06:00 [entrez]
PHST- 2011/03/05 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
AID - 18/2/209 [pii]
AID - 10.1177/0969733010389257 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Mar;18(2):209-16. doi: 10.1177/0969733010389257.


PMID- 21372233
OWN - NLM
STAT- MEDLINE
DCOM- 20110715
LR  - 20110304
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 2
DP  - 2011 Mar
TI  - Ethics of caring and professional roles.
PG  - 201-8
LID - 10.1177/0969733010392302 [doi]
AB  - Normative discussions about modern health care often revolve around principles
      stating what must not be done or how to ration scarce resources in the name of
      justice. These are important discussions. However, in order to have an impact on 
      clinical roles, ethical reflection must be able to describe and address the
      complexities and challenges of modern nursing and doctoring, and maybe even the
      patient role. A multi-principled approach, such as the one suggested by Beauchamp
      and Childress, can obviously address almost any such issue, but a great deal of
      translation is often required in order to address role-related issues. I shall
      here argue that an ethics of caring is better suited to grasping the big picture 
      when the question is how to create value-informed clinical roles in an era of
      rapid development.
FAU - Paulsen, Jens Erik
AU  - Paulsen JE
AD  - Centre for Medical Ethics, University of Oslo, PO Box 1130, Blindern, NO-0318
      Oslo, Norway. j.e.paulsen@medisin.uio.no
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Attitude of Health Personnel
MH  - Empathy/ethics
MH  - Ethical Theory
MH  - *Ethics, Medical
MH  - Humans
MH  - Morals
MH  - Patient Care/*ethics
MH  - *Principle-Based Ethics
MH  - *Professional Role
MH  - Professional-Patient Relations/*ethics
EDAT- 2011/03/05 06:00
MHDA- 2011/07/16 06:00
CRDT- 2011/03/05 06:00
PHST- 2011/03/05 06:00 [entrez]
PHST- 2011/03/05 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
AID - 18/2/201 [pii]
AID - 10.1177/0969733010392302 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Mar;18(2):201-8. doi: 10.1177/0969733010392302.


PMID- 21372232
OWN - NLM
STAT- MEDLINE
DCOM- 20110715
LR  - 20220408
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 2
DP  - 2011 Mar
TI  - The ethics of care: role obligations and moderate partiality in health care.
PG  - 192-200
LID - 10.1177/0969733010388926 [doi]
AB  - This article contends that an ethics of care has a particular moral ontology that
      makes it suitable to argue for the normative significance of relational
      responsibilities within professional health care. This ontology is relational. It
      means that moral choices always have to account for the web of relationships, the
      relational networks and responsibilities that are an essential part of particular
      moral circumstances. Given this ontology, the article investigates the conditions
      for health care professionals to be partial and to act on the basis of particular
      responsibilities to their patients. We will argue that priorities could be
      partial in three ways: first, because there may be exceptional circumstances that
      allow for giving priority to one patient over another; second, because the
      integrity of the patient and a health care worker may be connected in special
      ways; and, finally, even if impartiality is essential, the institutional basis of
      health care must always give ample space for an ethically qualified individual
      and personal care for patients. Even if difficult priorities may be necessary,
      the conditions of institutional health care should always seek to create the
      prerequisites for nurses and doctors to administer proper care.
FAU - Nortvedt, Per
AU  - Nortvedt P
AD  - Section for Medical Ethics, Institute of Health and Society, University of Oslo, 
      PO 1130, Blindern, NO-0318 Oslo, Norway. p.nortvedt@medisin.uio.no
FAU - Hem, Marit Helene
AU  - Hem MH
FAU - Skirbekk, Helge
AU  - Skirbekk H
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
CIN - Nurs Ethics. 2011 Mar;18(2):243-54; discussion 262-71. PMID: 21372237
CIN - Nurs Ethics. 2011 Mar;18(2):255-7. PMID: 21372238
CIN - Nurs Ethics. 2011 Mar;18(2):258-61. PMID: 21372239
MH  - Empathy/*ethics
MH  - Ethical Theory
MH  - *Ethics, Nursing
MH  - Humans
MH  - *Moral Obligations
MH  - Morals
MH  - *Nurse's Role
MH  - Nurse-Patient Relations/ethics
MH  - Nursing Care/*ethics
MH  - Principle-Based Ethics
EDAT- 2011/03/05 06:00
MHDA- 2011/07/16 06:00
CRDT- 2011/03/05 06:00
PHST- 2011/03/05 06:00 [entrez]
PHST- 2011/03/05 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
AID - 18/2/192 [pii]
AID - 10.1177/0969733010388926 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Mar;18(2):192-200. doi: 10.1177/0969733010388926.


PMID- 21372231
OWN - NLM
STAT- MEDLINE
DCOM- 20110715
LR  - 20110304
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 2
DP  - 2011 Mar
TI  - Is there a distinctive care ethics?
PG  - 184-91
LID - 10.1177/0969733010389431 [doi]
AB  - Is it true that an ethics of care offers something distinct from other approaches
      to ethical problems in nursing, especially principlism? In this article an
      attempt is made to clarify an ethics of care and then to argue that there need be
      no substantial difference between principlism and an ethics of care when the
      latter is considered in the context of nursing. The article begins by considering
      the question of how one could in fact differentiate moral theories. As is
      explained, this cannot be done merely in light of the moral judgements they
      defend, nor their ontological commitments (e.g. their view of the nature of
      persons). Following these methodological beginnings, care-based ethics is
      described and critically discussed. It is shown that ontological commitments
      embraced within care ethics do not themselves show that care ethics is distinct
      from other approaches. The idea of 'psychological care' is also discussed, which 
      stems from the work of Margaret Little. Her claim that the 'gestalts' of justice 
      and care cannot be combined is rejected in favour of an approach that does just
      that and which has been developed by Joan Tronto. It is then claimed that the
      moral commitments of principlism are certainly not incompatible with those of an 
      ethics of care in the nursing context. A challenge to the idea that principlism
      and ethics of care might be compatible is anticipated in the work of Eva Feder
      Kittay. This challenge is responded to and it is concluded that care considered
      as a moral orientation and the moral values embedded in principlism are best
      combined in the nursing context. Care provides a moral orientation over which the
      obligations referred to in principlism can be laid.
FAU - Edwards, Steven D
AU  - Edwards SD
AD  - Department of Philosophy, History and Law, School of Health and Human Science,
      Swansea University, Swansea SA2 8PP, UK. s.d.edwards@swansea.ac.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
CIN - Nurs Ethics. 2011 Mar;18(2):255-7. PMID: 21372238
CIN - Nurs Ethics. 2011 Mar;18(2):258-61. PMID: 21372239
MH  - Empathy/*ethics
MH  - *Ethical Theory
MH  - Ethics, Nursing
MH  - Humans
MH  - Moral Obligations
MH  - Nurse's Role
MH  - Nurse-Patient Relations/*ethics
MH  - Nursing Care/*ethics
MH  - *Nursing Theory
MH  - *Philosophy, Nursing
MH  - Principle-Based Ethics
MH  - Professional Competence
EDAT- 2011/03/05 06:00
MHDA- 2011/07/16 06:00
CRDT- 2011/03/05 06:00
PHST- 2011/03/05 06:00 [entrez]
PHST- 2011/03/05 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
AID - 18/2/184 [pii]
AID - 10.1177/0969733010389431 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Mar;18(2):184-91. doi: 10.1177/0969733010389431.


PMID- 21372230
OWN - NLM
STAT- MEDLINE
DCOM- 20110715
LR  - 20110304
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 2
DP  - 2011 Mar
TI  - Harm in the absence of care: Towards a medical ethics that cares.
PG  - 174-83
LID - 10.1177/0969733010392304 [doi]
AB  - The aim of this article is to investigate the concept of care in contemporary
      medical practice and medical ethics. Although care has been hailed throughout the
      centuries as a crucial ideal in medical practice and as an honourable virtue to
      be observed in codes of medical ethics, I argue that contemporary medicine and
      medical ethics suffer from the lack of a theoretically sustainable concept of
      care and then discuss possible reasons that may help to explain this absence. I
      draw on the empirical studies of Carol Gilligan on care and connectedness as
      ontologically situated realities in human life. Based on a philosophical
      elaboration of her findings on the ethics of care emphasizing relationality, I
      try to show how the notion of 'relational ontology' originating from this stream 
      of thought may be of help in developing a medical ethics that acknowledges care
      as a perspective to be observed in all interactions between physicians and
      patients.
FAU - Martinsen, Elin
AU  - Martinsen E
AD  - Section for Medical Ethics, Institute of Health and Society, Faculty of Medicine,
      University of Oslo, PO BOX 1130, Blindern, 0318 Oslo, Norway.
      e.h.martinsen@medisin.uio.no
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
CIN - Nurs Ethics. 2011 Mar;18(2):243-54; discussion 262-71. PMID: 21372237
CIN - Nurs Ethics. 2011 Mar;18(2):258-61. PMID: 21372239
MH  - Empathy/ethics
MH  - Ethical Theory
MH  - *Ethics, Clinical
MH  - *Ethics, Medical
MH  - Humans
MH  - Morals
MH  - Patient Advocacy/ethics
MH  - Patient Care/*ethics
MH  - *Principle-Based Ethics
MH  - Professional-Patient Relations/*ethics
MH  - Social Values
MH  - *Virtues
EDAT- 2011/03/05 06:00
MHDA- 2011/07/16 06:00
CRDT- 2011/03/05 06:00
PHST- 2011/03/05 06:00 [entrez]
PHST- 2011/03/05 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
AID - 18/2/174 [pii]
AID - 10.1177/0969733010392304 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Mar;18(2):174-83. doi: 10.1177/0969733010392304.


PMID- 21372229
OWN - NLM
STAT- MEDLINE
DCOM- 20110715
LR  - 20220317
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 2
DP  - 2011 Mar
TI  - A personalist approach to care ethics.
PG  - 161-73
LID - 10.1177/0969733010388924 [doi]
AB  - Notwithstanding the fact that care ethics has received increased attention, it
      has also faced much criticism. One of the focal points of critics is the
      normativity of care. Only when the objective normative basis of care is
      sufficiently clarified can care practices be evaluated and optimized from an
      ethical point of view. We emphasize that two levels of normativity can be
      identified: the context level and the foundational anthropology level. The
      personalist approach to care ethics is normatively stronger, at least on one
      level, namely the foundational anthropology level. This personalist approach to
      care ethics indicates in which direction action must be taken so that human
      action may be considered ethically sound.
FAU - Vanlaere, Linus
AU  - Vanlaere L
AD  - sTimul: Care-Ethics Lab, Sint-Maartensplein 13, 8560 Moorsele, Belgium.
      linus.vanlaere@stimul.be
FAU - Gastmans, Chris
AU  - Gastmans C
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
CIN - Nurs Ethics. 2011 Mar;18(2):243-54; discussion 262-71. PMID: 21372237
CIN - Nurs Ethics. 2011 Mar;18(2):255-7. PMID: 21372238
CIN - Nurs Ethics. 2011 Mar;18(2):258-61. PMID: 21372239
MH  - Empathy/ethics
MH  - *Ethical Theory
MH  - Ethics, Nursing
MH  - Evidence-Based Nursing
MH  - Humans
MH  - Moral Obligations
MH  - Morals
MH  - *Nurse's Role
MH  - Nurse-Patient Relations/*ethics
MH  - Nursing Care/*ethics
MH  - *Philosophy, Nursing
MH  - *Principle-Based Ethics
EDAT- 2011/03/05 06:00
MHDA- 2011/07/16 06:00
CRDT- 2011/03/05 06:00
PHST- 2011/03/05 06:00 [entrez]
PHST- 2011/03/05 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
AID - 18/2/161 [pii]
AID - 10.1177/0969733010388924 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Mar;18(2):161-73. doi: 10.1177/0969733010388924.


PMID- 21372228
OWN - NLM
STAT- MEDLINE
DCOM- 20110715
LR  - 20110304
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 2
DP  - 2011 Mar
TI  - Caring, objectivity and justice: an integrative view.
PG  - 149-60
LID - 10.1177/0969733010388927 [doi]
AB  - The argument of this article is framed by a debate between the principle of
      humanity and the principle of justice. Whereas the principle of humanity requires
      us to care about others and to want to help them meet their vital needs, and so
      to be partial towards those others, the principle of justice requires us to
      consider their needs without the intrusion of our subjective interests or
      emotions so that we can act with impartiality. I argue that a deep form of caring
      lies behind both approaches and so unites them. In the course of the argument, I 
      reject Michael Slote's sentimentalist form of an ethics of care, and expound
      Thomas Nagel's moral theory, which seems to lie at the opposite end of a spectrum
      ranging from moral sentiments to impersonal objectivity. Nevertheless, Nagel's
      theory of normative realism provides unexpected support for the thesis that a
      deep and subjective form of caring lies at the base of even our most objective
      moral reasons.
FAU - van Hooft, Stan
AU  - van Hooft S
AD  - Faculty of Arts and Education, Deakin University, 221 Burwood Highway, Burwood,
      Victoria 3125, Australia. stanvh@deakin.edu.au
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
CIN - Nurs Ethics. 2011 Mar;18(2):243-54; discussion 262-71. PMID: 21372237
MH  - Emotions
MH  - *Empathy
MH  - *Ethics, Nursing
MH  - Evidence-Based Nursing
MH  - Humans
MH  - Models, Nursing
MH  - *Morals
MH  - *Nurse's Role
MH  - Nurse-Patient Relations/*ethics
MH  - Nursing Care/*ethics
MH  - Patient Advocacy/ethics
MH  - Social Perception
EDAT- 2011/03/05 06:00
MHDA- 2011/07/16 06:00
CRDT- 2011/03/05 06:00
PHST- 2011/03/05 06:00 [entrez]
PHST- 2011/03/05 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
AID - 18/2/149 [pii]
AID - 10.1177/0969733010388927 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Mar;18(2):149-60. doi: 10.1177/0969733010388927.


PMID- 21372227
OWN - NLM
STAT- MEDLINE
DCOM- 20110715
LR  - 20110304
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 2
DP  - 2011 Mar
TI  - An ethics of care: normative challenges.
PG  - 147-8
LID - 10.1177/0969733010393072 [doi]
FAU - Nortvedt, Per
AU  - Nortvedt P
LA  - eng
PT  - Editorial
PT  - Introductory Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - *Ethics, Nursing
MH  - Evidence-Based Nursing
MH  - Humans
MH  - Models, Nursing
MH  - Morals
MH  - Norway
MH  - *Nurse's Role
MH  - Nurse-Patient Relations/*ethics
MH  - Nursing Care/*ethics
MH  - Patient Advocacy/ethics
EDAT- 2011/03/05 06:00
MHDA- 2011/07/16 06:00
CRDT- 2011/03/05 06:00
PHST- 2011/03/05 06:00 [entrez]
PHST- 2011/03/05 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
AID - 18/2/147 [pii]
AID - 10.1177/0969733010393072 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Mar;18(2):147-8. doi: 10.1177/0969733010393072.


PMID- 21372150
OWN - NLM
STAT- MEDLINE
DCOM- 20110823
LR  - 20220331
IS  - 1479-6805 (Electronic)
IS  - 0022-0795 (Linking)
VI  - 210
IP  - 1
DP  - 2011 Jul
TI  - Bridging endometrial receptivity and implantation: network of hormones,
      cytokines, and growth factors.
PG  - 5-14
LID - 10.1530/JOE-10-0461 [doi]
AB  - The prerequisite of successful implantation depends on achieving the appropriate 
      embryo development to the blastocyst stage and at the same time the development
      of an endometrium that is receptive to the embryo. Implantation is a very
      intricate process, which is controlled by a number of complex molecules like
      hormones, cytokines, and growth factors and their cross talk. A network of these 
      molecules plays a crucial role in preparing receptive endometrium and blastocyst.
      Furthermore, timely regulation of the expression of embryonic and maternal
      endometrial growth factors and cytokines plays a major role in determining the
      fate of embryo. Most of the existing data comes from animal studies due to
      ethical issues. In this study, we comprehend the data from both animal models and
      humans for better understanding of implantation and positive outcomes of
      pregnancy. The purpose of this review is to describe the potential roles of
      embryonic and uterine factors in implantation process such as prostaglandins,
      cyclooxygenases, leukemia inhibitory factor, interleukin (IL) 6, IL11,
      transforming growth factor-beta, IGF, activins, NODAL, epidermal growth factor
      (EGF), and heparin binding-EGF. Understanding the function of these players will 
      help us to address the reasons of implantation failure and infertility.
CI  - (c) 2011 Society for Endocrinology
FAU - Singh, Mohan
AU  - Singh M
AD  - Research Group in Molecular Oncology and Endocrinology, Department of
      Chemistry-Biology, University of Quebec, Trois-Rivieres, 3351, Boulevard Des
      Forges, CP 500, Trois-Rivieres, Quebec G8Y 5H7, Canada.
FAU - Chaudhry, Parvesh
AU  - Chaudhry P
FAU - Asselin, Eric
AU  - Asselin E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110303
PL  - England
TA  - J Endocrinol
JT  - The Journal of endocrinology
JID - 0375363
RN  - 0 (Cytokines)
RN  - 0 (Hormones)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
SB  - IM
MH  - Animals
MH  - Cytokines/*metabolism
MH  - *Embryo Implantation
MH  - Endometrium/*physiology
MH  - Female
MH  - Hormones/*metabolism
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins/*metabolism
MH  - Pregnancy
MH  - Pregnancy Outcome
EDAT- 2011/03/05 06:00
MHDA- 2011/08/24 06:00
CRDT- 2011/03/05 06:00
PHST- 2011/03/05 06:00 [entrez]
PHST- 2011/03/05 06:00 [pubmed]
PHST- 2011/08/24 06:00 [medline]
AID - JOE-10-0461 [pii]
AID - 10.1530/JOE-10-0461 [doi]
PST - ppublish
SO  - J Endocrinol. 2011 Jul;210(1):5-14. doi: 10.1530/JOE-10-0461. Epub 2011 Mar 3.


PMID- 21371966
OWN - NLM
STAT- MEDLINE
DCOM- 20110714
LR  - 20220129
IS  - 2151-2396 (Electronic)
IS  - 0227-5910 (Linking)
VI  - 32
IP  - 1
DP  - 2011
TI  - Doing qualitative research on suicide in a developing country: practical and
      ethical challenges.
PG  - 15-23
LID - 10.1027/0227-5910/a000047 [doi]
AB  - BACKGROUND: This article describes and discusses the challenges faced by
      researchers who conducted a qualitative interview study on attitudes toward
      suicide among the Baganda, Uganda. Many of the challenges addressed in this
      article have not been described earlier in suicide research conducted in the
      developing world. AIMS: The aim of this study was to explore attitudes and
      cultural responses toward suicide among the Baganda, Uganda. METHODS: Data were
      collected and analyzed using grounded theory. A total of 28 focus group
      discussions and 30 key informant interviews were conducted. RESULTS: The findings
      of this study are organized under two broad categories: community access
      challenges and expectation challenges. Community access challenges entailed
      cultural, legal, rapport, informed consent, language, and other research process 
      related issues that could hinder effective access to the study respondents.
      Expectation challenges concerned how to deal with the immediate and strategic
      needs of the study communities. CONCLUSIONS: This study demonstrates that
      culturally sensitive approaches to data collection can reduce ethical challenges 
      and, through innovative approaches, practical challenges faced during data
      collection can be minimized.
FAU - Mugisha, James
AU  - Mugisha J
AD  - Norwegian University of Science and Technology, Trondheim, Norway.
      jmmugi77@hotmail.com
FAU - Knizek, Birthe Loa
AU  - Knizek BL
FAU - Kinyanda, Eugene
AU  - Kinyanda E
FAU - Hjelmeland, Heidi
AU  - Hjelmeland H
LA  - eng
GR  - MC_U950088495/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Canada
TA  - Crisis
JT  - Crisis
JID - 8218602
SB  - IM
EIN - Crisis. 2011;32(2):64
MH  - Attitude to Health
MH  - *Behavioral Research/ethics/methods
MH  - Communication
MH  - Culture
MH  - *Developing Countries
MH  - Humans
MH  - Informed Consent
MH  - Interviews as Topic/methods
MH  - *Suicide
MH  - Uganda
EDAT- 2011/03/05 06:00
MHDA- 2011/07/16 06:00
CRDT- 2011/03/05 06:00
PHST- 2011/03/05 06:00 [entrez]
PHST- 2011/03/05 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
AID - WWV8703605143655 [pii]
AID - 10.1027/0227-5910/a000047 [doi]
PST - ppublish
SO  - Crisis. 2011;32(1):15-23. doi: 10.1027/0227-5910/a000047.


PMID- 21371511
OWN - NLM
STAT- MEDLINE
DCOM- 20110928
LR  - 20211020
IS  - 1872-8294 (Electronic)
IS  - 0169-409X (Linking)
VI  - 63
IP  - 4-5
DP  - 2011 Apr 30
TI  - Induced pluripotent stem cells for regenerative cardiovascular therapies and
      biomedical discovery.
PG  - 324-30
LID - 10.1016/j.addr.2011.01.013 [doi]
AB  - The discovery of induced pluripotent stem cells (iPSC) has, in the short time
      since their discovery, revolutionized the field of stem cell biology. This
      technology allows the generation of a virtually unlimited supply of cells with
      pluripotent potential similar to that of embryonic stem cells (ESC). However, in 
      contrast to ESC, iPSC are not subject to the same ethical concerns and can be
      easily generated from living individuals. For the first time, patient-specific
      iPSC can be generated and offer a supply of genetically identical cells that can 
      be differentiated into all somatic cell types for potential use in regenerative
      therapies or drug screening and testing. As the techniques for generation of iPSC
      lines are constantly evolving, new uses for human iPSC are emerging from in-vitro
      disease modeling to high throughput drug discovery and screening. This technology
      promises to revolutionize the field of medicine and offers new hope for
      understanding and treatment of numerous diseases.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Nsair, Ali
AU  - Nsair A
AD  - Department of Medicine, Cardiovascular Research Laboratories and Eli Broad Center
      for Regenerative Medicine and Stem Cell Research,David Geffen School of Medicine 
      at UCLA, United States
FAU - MacLellan, W Robb
AU  - MacLellan WR
LA  - eng
GR  - HL094941/HL/NHLBI NIH HHS/United States
GR  - HL080111/HL/NHLBI NIH HHS/United States
GR  - P01 HL080111/HL/NHLBI NIH HHS/United States
GR  - R21 HL094941/HL/NHLBI NIH HHS/United States
GR  - R21 HL094941-02/HL/NHLBI NIH HHS/United States
GR  - R01 HL070748/HL/NHLBI NIH HHS/United States
GR  - R01 HL070748-04/HL/NHLBI NIH HHS/United States
GR  - R01 HL070748-06/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110301
PL  - Netherlands
TA  - Adv Drug Deliv Rev
JT  - Advanced drug delivery reviews
JID - 8710523
SB  - IM
MH  - Animals
MH  - Cardiovascular Diseases/physiopathology/*therapy
MH  - Cell Differentiation
MH  - Cellular Reprogramming
MH  - Drug Discovery/methods
MH  - High-Throughput Screening Assays
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*metabolism
MH  - Regenerative Medicine/*methods
PMC - PMC3109180
MID - NIHMS285589
EDAT- 2011/03/05 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/03/05 06:00
PHST- 2010/11/19 00:00 [received]
PHST- 2011/01/17 00:00 [revised]
PHST- 2011/01/31 00:00 [accepted]
PHST- 2011/03/05 06:00 [entrez]
PHST- 2011/03/05 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - S0169-409X(11)00041-X [pii]
AID - 10.1016/j.addr.2011.01.013 [doi]
PST - ppublish
SO  - Adv Drug Deliv Rev. 2011 Apr 30;63(4-5):324-30. doi: 10.1016/j.addr.2011.01.013. 
      Epub 2011 Mar 1.


PMID- 21371306
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 1472-684X (Electronic)
IS  - 1472-684X (Linking)
VI  - 10
DP  - 2011 Mar 3
TI  - "Card sorting": a tool for research in ethics on treatment decision-making at the
      end of life in Alzheimer patients with a life threatening complication.
PG  - 4
LID - 10.1186/1472-684X-10-4 [doi]
AB  - BACKGROUND: End stage dementia is a particularly difficult aspect of care for
      patients with Alzheimer's disease and related dementias. In care institutions,
      caregivers and family are concerned by treatment decision-making for an acute
      life threatening complication occurring in Alzheimer patients at the end of life.
      How should the best treatment pathway be decided: to treat or not to treat? Which
      arguments are used for decision-making? These are mainly ethical questions which 
      are currently difficult to express and investigate. METHODS/DESIGN: Cross
      sectional multicentre study of clinical cases involving 67 health centres
      (university hospitals, general hospitals, local hospitals and homes for the
      elderly) in the east of France. The method was based on the "card sorting"
      technique, with a set of 36 cards, each labelled with a different item relating
      to arguments for treatment decision-making. For each clinical case, medical staff
      and carers expressed in a meeting the pieces of information which they believed
      had been taken into account in the decision. Each participant received a card
      game, selected fewer than ten and ranked them according to the importance they
      attached to each one. All selected cards were then put on the table anonymously
      for participants, respecting the order of importance of the cards in each pile.
      Lastly, all games were photographed together in order to analyse occurrence and
      order frequencies. The cards were then classified on the table by frequency to
      open the discussion. Discussion time, which was conducted by the head carer of
      the department, concerned the clinical situation of the patient based on the
      shared responses. DISCUSSION: During team meetings, the "card sorting" method was
      quickly adopted by professionals as a tool to assist with discussion beyond the
      context of the study. The participants were not compelled to mention their
      feelings in relation to a case, and it is significant that the anonymity which we
      tried to maintain so that each person felt "listened to" without value judgement 
      was very often discarded by the individuals themselves.
FAU - Pazart, Lionel
AU  - Pazart L
AD  - Clinical Investigation Centre, Inserm CIT 808, Besancon University Hospital, 2,
      Place St Jacques, 25030 Besancon, France. lpazart@chu-besancon.fr.
FAU - Vidal, Chrystelle
AU  - Vidal C
FAU - Chalon, Didier Faivre
AU  - Chalon DF
FAU - Gauthier, Sophie
AU  - Gauthier S
FAU - Schepens, Florent
AU  - Schepens F
FAU - Cretin, Elodie
AU  - Cretin E
FAU - Beal, Jean-Louis
AU  - Beal JL
FAU - Pfitzenmeyer, Pierre
AU  - Pfitzenmeyer P
FAU - Aubry, Regis
AU  - Aubry R
LA  - eng
PT  - Journal Article
DEP - 20110303
PL  - England
TA  - BMC Palliat Care
JT  - BMC palliative care
JID - 101088685
PMC - PMC3056822
EDAT- 2011/03/05 06:00
MHDA- 2011/03/05 06:01
CRDT- 2011/03/05 06:00
PHST- 2011/01/27 00:00 [received]
PHST- 2011/03/03 00:00 [accepted]
PHST- 2011/03/05 06:00 [entrez]
PHST- 2011/03/05 06:00 [pubmed]
PHST- 2011/03/05 06:01 [medline]
AID - 1472-684X-10-4 [pii]
AID - 10.1186/1472-684X-10-4 [doi]
PST - epublish
SO  - BMC Palliat Care. 2011 Mar 3;10:4. doi: 10.1186/1472-684X-10-4.


PMID- 21371249
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20211020
IS  - 1466-769X (Electronic)
IS  - 1466-7681 (Linking)
VI  - 12
IP  - 2
DP  - 2011 Apr
TI  - Integrity at work: managing routine moral stress in professional roles.
PG  - 119-27
LID - 10.1111/j.1466-769X.2011.00484.x [doi]
AB  - In this paper I consider the routine moral burden of occupying a professional
      role and having to negotiate tensions between the normative expectations attached
      to that role and one's own personal moral compass. Using an example to introduce 
      this central issue I then seek to explore it through a discussion of the tensions
      between, and spaces between, 'identifying' with one's role and 'separating'
      oneself from one's role. I suggest that ethical integrity at work is revealed
      through the successful negotiation of these tensions, but that such negotiation
      depends upon the power and other resources available to individual professionals.
      Finally I argue that this discussion of 'the ethics of role occupation' has
      important implication for 'the ethics of role construction' and adds weight to
      concerns about the potential moral costs of managerialism.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Cribb, Alan
AU  - Cribb A
AD  - Centre for Public Policy Research, King's College London, London, UK.
      alan.cribb@kcl.ac.uk
LA  - eng
GR  - 086034/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PL  - England
TA  - Nurs Philos
JT  - Nursing philosophy : an international journal for healthcare professionals
JID - 100897394
SB  - IM
MH  - *Ethics, Nursing
MH  - Humans
MH  - *Moral Obligations
MH  - *Nurse's Role
MH  - *Philosophy, Nursing
MH  - *Professional Practice
MH  - *Stress, Psychological
MH  - *Workplace
EDAT- 2011/03/05 06:00
MHDA- 2011/07/27 06:00
CRDT- 2011/03/05 06:00
PHST- 2011/03/05 06:00 [entrez]
PHST- 2011/03/05 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
AID - 10.1111/j.1466-769X.2011.00484.x [doi]
PST - ppublish
SO  - Nurs Philos. 2011 Apr;12(2):119-27. doi: 10.1111/j.1466-769X.2011.00484.x.


PMID- 21371248
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20220408
IS  - 1466-769X (Electronic)
IS  - 1466-7681 (Linking)
VI  - 12
IP  - 2
DP  - 2011 Apr
TI  - Integrity: is it still relevant to modern healthcare?
PG  - 107-18
LID - 10.1111/j.1466-769X.2011.00486.x [doi]
AB  - Personal integrity is often seen as a core value for delivering ethical
      healthcare. This paper will explore what this might mean and particularly what
      place integrity has in a multi-professional healthcare system. Two opposing
      arguments can be made: the first is that the multi-professional nature of modern 
      healthcare means that personal integrity is at best a futile luxury and at worst,
      an obstacle to delivering affordable high-quality care to large populations. The 
      converse is that without personal integrity healthcare loses its humanity and
      becomes mere biological and social engineering. Part of the analysis rests on
      whether integrity is primarily a personally held moral framework or whether it is
      a social concept. Chester Calhoun's analysis, in which she identifies the
      integrated-self, personal identity, and (morally) clean-hands as three pictures
      of integrity, is used as the basis for suggesting that integrity is a rich and
      complex social virtue through which the individual is able to demonstrate their
      relationship with the values and mores of the communities of which they are
      members. In addition, I will argue that integrity is not a value itself, but is a
      framework through which one or more sets of those values that characterize the
      communities of which the person is a part, can be expressed. Because a person may
      belong to many communities - nation, gender, religion, family, profession, trade,
      sport, etc. - each individual has their own unique meta-set of values that
      informs their personal sense of integrity. However, in specific circumstances,
      conflicts may arise between this personal global sense and the set of values
      associated with one community.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Tyreman, Stephen
AU  - Tyreman S
AD  - Osteopathic Education Development, British School of Osteopathy (BSO), London,
      UK. s.tyreman@bso.ac.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Philos
JT  - Nursing philosophy : an international journal for healthcare professionals
JID - 100897394
SB  - IM
MH  - Codes of Ethics
MH  - *Ethics, Nursing
MH  - Humans
MH  - *Moral Obligations
MH  - *Nurse-Patient Relations
MH  - *Philosophy, Nursing
MH  - *Self Concept
EDAT- 2011/03/05 06:00
MHDA- 2011/07/27 06:00
CRDT- 2011/03/05 06:00
PHST- 2011/03/05 06:00 [entrez]
PHST- 2011/03/05 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
AID - 10.1111/j.1466-769X.2011.00486.x [doi]
PST - ppublish
SO  - Nurs Philos. 2011 Apr;12(2):107-18. doi: 10.1111/j.1466-769X.2011.00486.x.


PMID- 21370972
OWN - NLM
STAT- MEDLINE
DCOM- 20130816
LR  - 20181201
IS  - 1545-2107 (Electronic)
IS  - 0066-4286 (Linking)
VI  - 49
DP  - 2011
TI  - Norman Borlaug: the man I worked with and knew.
PG  - 17-30
LID - 10.1146/annurev-phyto-072910-095308 [doi]
AB  - Much has been written about Norman Borlaug the agricultural scientist and
      humanitarian whose achievements are recognized with many accolades; to add to
      those writings is a difficult task. This brief paper is an attempt to provide a
      personal perspective on Norman Borlaug that can come only from someone who has
      worked closely with him throughout his professional life. I have endeavored to
      recollect my early impressions of working with Borlaug as a wheat breeder in
      Mexico and to highlight his innovative approach to wheat breeding, as well as his
      views on global population and food security, fertilizers, organic agriculture,
      biotechnology, and conventional academia. His work ethic was instrumental in his 
      vision for the international agricultural system as an instrument of change in
      the world. His spirit serves as a reminder to future agricultural scientists that
      the battle must be vigorously engaged and can be won.
CI  - Copyright (c) 2011 by Annual Reviews. All rights reserved.
FAU - Rajaram, Sanjaya
AU  - Rajaram S
AD  - Resource Seeds International, Toluca, Mexico.
LA  - eng
PT  - Biography
PT  - Historical Article
PT  - Journal Article
PT  - Portrait
PL  - United States
TA  - Annu Rev Phytopathol
JT  - Annual review of phytopathology
JID - 0372373
RN  - 0 (Fertilizers)
SB  - IM
MH  - Agriculture/*history/trends
MH  - Biotechnology/history
MH  - Breeding/history
MH  - Fertilizers/history
MH  - *Food Supply/history
MH  - Global Health/history
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Mexico
MH  - Nobel Prize
MH  - Triticum/genetics/history
MH  - United States
PS  - Borlaug N
FPS - Borlaug, Norman
EDAT- 2011/03/05 06:00
MHDA- 2013/08/21 06:00
CRDT- 2011/03/05 06:00
PHST- 2011/03/05 06:00 [entrez]
PHST- 2011/03/05 06:00 [pubmed]
PHST- 2013/08/21 06:00 [medline]
AID - 10.1146/annurev-phyto-072910-095308 [doi]
PST - ppublish
SO  - Annu Rev Phytopathol. 2011;49:17-30. doi: 10.1146/annurev-phyto-072910-095308.


PMID- 21368248
OWN - NLM
STAT- MEDLINE
DCOM- 20110317
LR  - 20110303
IS  - 1930-7837 (Electronic)
IS  - 0022-0337 (Linking)
VI  - 75
IP  - 3 Suppl
DP  - 2011 Mar
TI  - Ethics, trust, and global leadership: an IWLC Working Group report.
PG  - S33-34
FAU - Rambob, Isabel
AU  - Rambob I
AD  - Department of Oncology and Diagnostic Sciences, University of Maryland Baltimore,
      MD, USA.
FAU - Boyd, Marcia
AU  - Boyd M
FAU - Dillenberg, Jack
AU  - Dillenberg J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Dent Educ
JT  - Journal of dental education
JID - 8000150
SB  - IM
MH  - Cultural Competency
MH  - *Dentists, Women/ethics
MH  - Emotional Intelligence
MH  - *Ethics, Dental
MH  - Goals
MH  - Humans
MH  - Interprofessional Relations
MH  - *Leadership
MH  - Morals
MH  - Social Values
MH  - *Trust
EDAT- 2011/03/05 06:00
MHDA- 2011/03/18 06:00
CRDT- 2011/03/04 06:00
PHST- 2011/03/04 06:00 [entrez]
PHST- 2011/03/05 06:00 [pubmed]
PHST- 2011/03/18 06:00 [medline]
AID - 75/3suppl/S33 [pii]
PST - ppublish
SO  - J Dent Educ. 2011 Mar;75(3 Suppl):S33-34.


PMID- 21370085
OWN - NLM
STAT- MEDLINE
DCOM- 20110609
LR  - 20110303
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Linking)
VI  - 719
DP  - 2011
TI  - Computational analysis of high throughput sequencing data.
PG  - 199-217
LID - 10.1007/978-1-61779-027-0_9 [doi]
AB  - The advent of High Throughput Sequencing (HTS) methods opens new opportunities
      for the analysis of genomes and transcriptomes. While the sequencing of a whole
      mammalian genome took several years at the turn of this century, today it is only
      a matter of weeks. The race towards the thousand-dollar genome is fueled by the -
      ethically challenging - idea of personalized genomic medicine. However, these
      methods allow new and interesting insights in many aspects such as the discovery 
      of novel noncoding RNA classes, structural variants, or alternative splice sites 
      to name a few. Meanwhile, several methods for HTS have been introduced to the
      markets. Here, an overview on the technologies and the bioinformatics analysis of
      HTS data is given.
FAU - Hoffmann, Steve
AU  - Hoffmann S
AD  - Interdisciplinary Center for Bioinformatics and The Junior Research Group for
      Transcriptome Bioinformatics in the LIFE Research Cluster, University Leipzig,
      Leipzig, Germany. steve@bioinf.uni-leipzig.de
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Chromosome Mapping
MH  - Computational Biology/*methods
MH  - Humans
MH  - Oligonucleotide Array Sequence Analysis
MH  - Sequence Analysis, DNA/*methods
MH  - Statistics as Topic
EDAT- 2011/03/04 06:00
MHDA- 2011/06/10 06:00
CRDT- 2011/03/04 06:00
PHST- 2011/03/04 06:00 [entrez]
PHST- 2011/03/04 06:00 [pubmed]
PHST- 2011/06/10 06:00 [medline]
AID - 10.1007/978-1-61779-027-0_9 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2011;719:199-217. doi: 10.1007/978-1-61779-027-0_9.


PMID- 21370028
OWN - NLM
STAT- MEDLINE
DCOM- 20110608
LR  - 20110303
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Linking)
VI  - 717
DP  - 2011
TI  - Imaging techniques in signal transduction IHC.
PG  - 113-42
LID - 10.1007/978-1-61779-024-9_7 [doi]
AB  - Augmentation of digital images is almost always a necessity in order to obtain a 
      reproduction that matches the appearance of the original. However, that
      augmentation can mislead if it is done incorrectly and not within reasonable
      limits. When procedures are in place for ensuring that originals are archived,
      and image manipulation steps are reported, scientists not only follow good
      laboratory practices, but also avoid ethical issues associated with
      postprocessing and protect their labs from any future allegations of scientific
      misconduct. Also, when procedures are in place for correct acquisition of images,
      the extent of postprocessing is minimized or eliminated. These procedures include
      color balancing (for brighfield images), keeping tonal values within the dynamic 
      range of the detector, frame averaging to eliminate noise (typically in
      fluorescence imaging), use of the highest bit depth when a choice is available,
      flatfield correction, and archiving of the image in a nonlossy format (not
      JPEG).When postprocessing is necessary, the commonly used applications for
      correction include Photoshop, and ImageJ, but a free program (GIMP) can also be
      used. Corrections to images include scaling the bit depth to higher and lower
      ranges, removing color casts from brightfield images, setting brightness and
      contrast, reducing color noise, reducing "grainy" noise, conversion of pure
      colors to grayscale, conversion of grayscale to colors typically used in
      fluorescence imaging, correction of uneven illumination and flatfield correction,
      blending color images (fluorescence), and extending the depth of focus. These
      corrections are explained in step-by-step procedures in the chapter that follows.
FAU - Sedgewick, Jerry
AU  - Sedgewick J
AD  - Sedgewick Initiatives, Saint Paul, MN, USA. jerry@imagingandanalysis.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
SB  - IM
MH  - Image Processing, Computer-Assisted/*methods
MH  - Immunohistochemistry/*methods
MH  - Signal Transduction
MH  - Software
EDAT- 2011/03/04 06:00
MHDA- 2011/06/09 06:00
CRDT- 2011/03/04 06:00
PHST- 2011/03/04 06:00 [entrez]
PHST- 2011/03/04 06:00 [pubmed]
PHST- 2011/06/09 06:00 [medline]
AID - 10.1007/978-1-61779-024-9_7 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2011;717:113-42. doi: 10.1007/978-1-61779-024-9_7.


PMID- 21370003
OWN - NLM
STAT- MEDLINE
DCOM- 20110613
LR  - 20131121
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Linking)
VI  - 724
DP  - 2011
TI  - Regulatory and ethical issues on the utilization of FFPE tissues in research.
PG  - 1-21
LID - 10.1007/978-1-61779-055-3_1 [doi]
AB  - Formalin-fixed, paraffin-embedded (FFPE) archival tissues and their associated
      diagnostic records represent an invaluable source of information on diseases
      where the patient outcomes are already known. Older archives contain many unique 
      FFPE tissue specimens that would be impossible to replicate today due to changes 
      in medical practice and technology. Unfortunately, there is no single regulatory 
      or bioethical standard that covers research with FFPE tissue specimens. This
      makes it difficult for researchers to prepare protocols involving FFPE tissues
      and equally difficult for Institutional Review Boards to evaluate them. In this
      review, focused on US regulatory policy, the application of the Common Rule and
      the Privacy Rule of the Health Insurance Portability and Accountability Act to
      research involving FFPE tissue specimens will be discussed. It will be shown that
      the difficulty in applying regulatory and ethical standards to FFPE tissues
      results not from the tissues themselves, but from the personally identifiable
      health information associated with the tissue specimens.
FAU - With, Catherine M
AU  - With CM
AD  - Legal Counsel, Armed Forces Institute of Pathology, Washington, DC, USA.
FAU - Evers, David L
AU  - Evers DL
FAU - Mason, Jeffrey T
AU  - Mason JT
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
RN  - 1HG84L3525 (Formaldehyde)
SB  - IM
MH  - *Ethics, Research
MH  - Formaldehyde/*chemistry
MH  - Informed Consent
MH  - Paraffin Embedding/*ethics/*methods
MH  - Research/*legislation & jurisprudence
MH  - Tissue Fixation/*ethics/*methods
EDAT- 2011/03/04 06:00
MHDA- 2011/06/15 06:00
CRDT- 2011/03/04 06:00
PHST- 2011/03/04 06:00 [entrez]
PHST- 2011/03/04 06:00 [pubmed]
PHST- 2011/06/15 06:00 [medline]
AID - 10.1007/978-1-61779-055-3_1 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2011;724:1-21. doi: 10.1007/978-1-61779-055-3_1.


PMID- 21369760
OWN - NLM
STAT- MEDLINE
DCOM- 20120116
LR  - 20211020
IS  - 1432-0932 (Electronic)
IS  - 0940-6719 (Linking)
VI  - 20
IP  - 9
DP  - 2011 Sep
TI  - A novel synthetic material for spinal fusion: a prospective clinical trial of
      porous bioactive titanium metal for lumbar interbody fusion.
PG  - 1486-95
LID - 10.1007/s00586-011-1728-3 [doi]
AB  - The objective of this study was to establish the efficacy and safety of porous
      bioactive titanium metal for use in a spinal fusion device, based on a
      prospective human clinical trial. A high-strength spinal interbody fusion device 
      was manufactured from porous titanium metal. A bioactive surface was produced by 
      simple chemical and thermal treatment. Five patients with unstable lumbar spine
      disease were treated surgically using this device in a clinical trial approved by
      our Ethics Review Committee and the University Hospital Medical Information
      Network. Clinical and radiological results were reported at the minimum follow-up
      period of 1 year. The optimal mechanical strength and interconnected structure of
      the porous titanium metal were adjusted for the device. The whole surface of
      porous titanium metal was treated uniformly and its bioactive ability was
      confirmed before clinical use. Successful bony union was achieved in all cases
      within 6 months without the need for autologous iliac crest bone grafting. Two
      specific findings including an anchoring effect and gap filling were evident
      radiologically. All clinical parameters improved significantly after the
      operation and no adverse effects were encountered during the follow-up period.
      Although a larger and longer-term follow-up clinical study is mandatory to reach 
      any firm conclusions, the study results show that this porous bioactive titanium 
      metal is promising material for a spinal fusion device.
FAU - Fujibayashi, Shunsuke
AU  - Fujibayashi S
AD  - Department of Orthopedic Surgery, Graduate School of Medicine, Kyoto University, 
      Kyoto 606-8507, Japan. shfuji@kuhp.kyoto-u.ac.jp
FAU - Takemoto, Mitsuru
AU  - Takemoto M
FAU - Neo, Masashi
AU  - Neo M
FAU - Matsushita, Tomiharu
AU  - Matsushita T
FAU - Kokubo, Tadashi
AU  - Kokubo T
FAU - Doi, Kenji
AU  - Doi K
FAU - Ito, Tatsuya
AU  - Ito T
FAU - Shimizu, Akira
AU  - Shimizu A
FAU - Nakamura, Takashi
AU  - Nakamura T
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110303
PL  - Germany
TA  - Eur Spine J
JT  - European spine journal : official publication of the European Spine Society, the 
      European Spinal Deformity Society, and the European Section of the Cervical Spine
      Research Society
JID - 9301980
RN  - D1JT611TNE (Titanium)
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Lumbar Vertebrae/*surgery
MH  - Male
MH  - Middle Aged
MH  - Pain Measurement
MH  - Patient Satisfaction
MH  - Prospective Studies
MH  - Spinal Fusion/*instrumentation/methods
MH  - Spondylolisthesis/*surgery
MH  - *Titanium
MH  - Treatment Outcome
PMC - PMC3175892
EDAT- 2011/03/04 06:00
MHDA- 2012/01/17 06:00
CRDT- 2011/03/04 06:00
PHST- 2010/12/06 00:00 [received]
PHST- 2011/02/16 00:00 [accepted]
PHST- 2011/01/23 00:00 [revised]
PHST- 2011/03/04 06:00 [entrez]
PHST- 2011/03/04 06:00 [pubmed]
PHST- 2012/01/17 06:00 [medline]
AID - 10.1007/s00586-011-1728-3 [doi]
PST - ppublish
SO  - Eur Spine J. 2011 Sep;20(9):1486-95. doi: 10.1007/s00586-011-1728-3. Epub 2011
      Mar 3.


PMID- 21369632
OWN - NLM
STAT- MEDLINE
DCOM- 20110623
LR  - 20200825
IS  - 0304-4602 (Print)
IS  - 0304-4602 (Linking)
VI  - 40
IP  - 1
DP  - 2011 Jan
TI  - Maternal and fetal best interests in day-to-day obstetrics.
PG  - 43-9
AB  - In medicine, it is the physician's obligation to promote and protect the
      patient's interest. In obstetrics, the ethical principles of beneficence and
      autonomy provide the fundamental framework which guides the management of all
      pregnant patients. As there is the need for consideration of the fetus, autonomy 
      can become a complex issue giving rise to what is sometimes called
      "maternal-fetal conflict." In this paper, we aim to discuss some scenarios we
      encounter in our day-to-day obstetric practice such as pre-eclampsia, fetal
      growth restriction and labour induction when the best interests of the mother and
      fetus may be conflicted. We hope to illustrate that logical consideration for
      maternal and fetal best interests is only possible when there is adequate
      knowledge to support clinical practice. Certainly, with the rapid availability of
      newer knowledge and technology, it is the duty of the physician to be educated
      continuously so as to protect the patient from harm.
FAU - Yeo, George S H
AU  - Yeo GS
AD  - Department of Maternal Fetal Medicine, KK Women's & Children's Hospital,
      Singapore. dr.george.sh.yeo@gmail.com
FAU - Lim, May Li
AU  - Lim ML
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Singapore
TA  - Ann Acad Med Singap
JT  - Annals of the Academy of Medicine, Singapore
JID - 7503289
SB  - IM
MH  - Beneficence
MH  - Clinical Competence
MH  - Conflict, Psychological
MH  - *Ethics, Medical
MH  - Female
MH  - Fetal Growth Retardation
MH  - Fetus
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - *Maternal Welfare
MH  - Maternal-Fetal Relations
MH  - Obstetrics/ethics/*methods
MH  - Patient Care/ethics
MH  - Patient Rights
MH  - *Personal Autonomy
MH  - Physician-Patient Relations/*ethics
MH  - Pregnancy
MH  - Pregnancy Complications
MH  - Prenatal Diagnosis
EDAT- 2011/03/04 06:00
MHDA- 2011/06/24 06:00
CRDT- 2011/03/04 06:00
PHST- 2011/03/04 06:00 [entrez]
PHST- 2011/03/04 06:00 [pubmed]
PHST- 2011/06/24 06:00 [medline]
PST - ppublish
SO  - Ann Acad Med Singap. 2011 Jan;40(1):43-9.


PMID- 21369630
OWN - NLM
STAT- MEDLINE
DCOM- 20110623
LR  - 20200825
IS  - 0304-4602 (Print)
IS  - 0304-4602 (Linking)
VI  - 40
IP  - 1
DP  - 2011 Jan
TI  - The ethics of responding to a novel pandemic.
PG  - 30-5
AB  - Recent epidemics and pandemics have highlighted a number of ethical concerns
      about the response to the increasing threat of emerging infectious diseases. Some
      of these ethical concerns are very fundamental. They include why a pandemic was
      declared, how much clinical information can be collected for public health
      without threatening patient confidentiality and how to ensure fairness in the
      distribution of resources. We discuss these issues and suggest approaches to
      resolve these dilemmas as we anticipate the next pandemic.
FAU - Ng, Esther S T
AU  - Ng ES
AD  - Department of Medicine, National University Health System, Singapore.
      u0302066@gmail.com
FAU - Tambyah, Paul Ananth
AU  - Tambyah PA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Singapore
TA  - Ann Acad Med Singap
JT  - Annals of the Academy of Medicine, Singapore
JID - 7503289
SB  - IM
MH  - Communicable Disease Control
MH  - Communicable Diseases/*epidemiology
MH  - Disease Outbreaks/*ethics
MH  - *Ethics, Medical
MH  - Global Health
MH  - Humans
MH  - Pandemics/*ethics
MH  - Public Health Practice/*ethics
MH  - Quarantine
MH  - Sentinel Surveillance
MH  - Singapore/epidemiology
EDAT- 2011/03/04 06:00
MHDA- 2011/06/24 06:00
CRDT- 2011/03/04 06:00
PHST- 2011/03/04 06:00 [entrez]
PHST- 2011/03/04 06:00 [pubmed]
PHST- 2011/06/24 06:00 [medline]
PST - ppublish
SO  - Ann Acad Med Singap. 2011 Jan;40(1):30-5.


PMID- 21369629
OWN - NLM
STAT- MEDLINE
DCOM- 20110623
LR  - 20200825
IS  - 0304-4602 (Print)
IS  - 0304-4602 (Linking)
VI  - 40
IP  - 1
DP  - 2011 Jan
TI  - An approach to the ethical evaluation of innovative surgical procedures.
PG  - 26-9
AB  - While there is an ethical obligation to improve clinical outcomes by developing
      better therapies, surgical innovation has largely progressed without the strict
      regulations required of novel pharmaceutical products. We explore the reasons why
      new surgical techniques are frequently introduced without the benefit of
      randomised controlled trials, and present an approach to the ethical evaluation
      of novel surgical procedures.
FAU - Tan, Veronique K M
AU  - Tan VK
AD  - Department of General Surgery, Singapore General Hospital, Singapore.
FAU - Chow, Pierce K H
AU  - Chow PK
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Singapore
TA  - Ann Acad Med Singap
JT  - Annals of the Academy of Medicine, Singapore
JID - 7503289
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Clinical Competence
MH  - *Diffusion of Innovation
MH  - *Ethics, Medical
MH  - General Surgery/*ethics/methods/standards
MH  - Humans
MH  - Informed Consent
MH  - Medical Audit
MH  - Medicine
MH  - Singapore
MH  - Specialty Boards
EDAT- 2011/03/04 06:00
MHDA- 2011/06/24 06:00
CRDT- 2011/03/04 06:00
PHST- 2011/03/04 06:00 [entrez]
PHST- 2011/03/04 06:00 [pubmed]
PHST- 2011/06/24 06:00 [medline]
PST - ppublish
SO  - Ann Acad Med Singap. 2011 Jan;40(1):26-9.


PMID- 21369627
OWN - NLM
STAT- MEDLINE
DCOM- 20110623
LR  - 20200825
IS  - 0304-4602 (Print)
IS  - 0304-4602 (Linking)
VI  - 40
IP  - 1
DP  - 2011 Jan
TI  - Evaluating the effects of an integrated medical ethics curriculum on first-year
      students.
PG  - 4-18
AB  - INTRODUCTION: An integrated biomedical ethics track was implemented as part of
      the new medical undergraduate curriculum at the National University of Singapore 
      Yong Loo Lin School of Medicine in academic year (AY) 2008/2009. This study
      analyses the effects of the new curriculum on fi rst-year students' knowledge,
      confidence and opinions in relation to the subject. MATERIALS AND METHODS: In a
      cohort-based quasi-experimental study, we administered a pre-course and
      post-course questionnaire to a group of fi rst-year students in AY2008/2009 who
      underwent the new biomedical ethics curriculum. The same questionnaire was
      carried out with the fi rst-year cohort of AY2007/2008, who had received only ad 
      hoc teaching in biomedical ethics. The questionnaire focused on the students'
      opinions on selected taught topics in biomedical ethics and law, and formal
      ethics education; their confidence in relation to specific clinical ethical
      competencies; and their knowledge of selected taught topics in the fi rst-year
      syllabus. RESULTS: The experimental cohort acquired more knowledge and
      confidence. They rated more positively formal ethics teaching and assessment as a
      requirement of medical education. Attitudes were found to have been
      'professionalised' within the experimental group, with significantly greater
      receptiveness towards ethical codes of the profession and the regulatory role of 
      the Singapore Medical Council. They were found to be more conservative with
      respect to legislative changes in healthcare. CONCLUSION: The pioneer biomedical 
      ethics curriculum had significant effects on the ethical development of fi
      rst-year medical students. Longitudinal research through further phases of the
      integrated curriculum is needed to identify learning issues that affect the
      consolidation of knowledge, confidence and attitudes in medical ethics, law and
      professionalism.
FAU - Chin, Jacqueline J L
AU  - Chin JJ
AD  - Centre for Biomedical Ethics, Yong Loo Lin School of Medicine, National
      University of Singapore, Singapore. medjcjl@nus.edu.sg
FAU - Voo, Teck Chuan
AU  - Voo TC
FAU - Karim, Syahirah Abdul
AU  - Karim SA
FAU - Chan, Yiong Huak
AU  - Chan YH
FAU - Campbell, Alastair V
AU  - Campbell AV
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - Singapore
TA  - Ann Acad Med Singap
JT  - Annals of the Academy of Medicine, Singapore
JID - 7503289
SB  - IM
MH  - Clinical Competence
MH  - Cohort Studies
MH  - *Curriculum
MH  - Education, Medical, Undergraduate/*methods
MH  - Ethics, Medical/*education
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Learning
MH  - Logistic Models
MH  - Male
MH  - Singapore
MH  - Students, Medical/*psychology
MH  - Surveys and Questionnaires
MH  - Teaching
EDAT- 2011/03/04 06:00
MHDA- 2011/06/24 06:00
CRDT- 2011/03/04 06:00
PHST- 2011/03/04 06:00 [entrez]
PHST- 2011/03/04 06:00 [pubmed]
PHST- 2011/06/24 06:00 [medline]
PST - ppublish
SO  - Ann Acad Med Singap. 2011 Jan;40(1):4-18.


PMID- 21369626
OWN - NLM
STAT- MEDLINE
DCOM- 20110623
LR  - 20200825
IS  - 0304-4602 (Print)
IS  - 0304-4602 (Linking)
VI  - 40
IP  - 1
DP  - 2011 Jan
TI  - Preserving medical ethics and professionalism: meeting the challenges of modern
      practice.
PG  - 1-3
FAU - Campbell, Alastair V
AU  - Campbell AV
FAU - Chin, Jing Jih
AU  - Chin JJ
LA  - eng
PT  - Editorial
PL  - Singapore
TA  - Ann Acad Med Singap
JT  - Annals of the Academy of Medicine, Singapore
JID - 7503289
SB  - IM
MH  - *Ethics, Medical
MH  - Humans
MH  - *Physician's Role
MH  - Physician-Patient Relations
MH  - *Practice Patterns, Physicians'
MH  - Singapore
MH  - *Social Identification
MH  - Social Responsibility
MH  - Trust
EDAT- 2011/03/04 06:00
MHDA- 2011/06/24 06:00
CRDT- 2011/03/04 06:00
PHST- 2011/03/04 06:00 [entrez]
PHST- 2011/03/04 06:00 [pubmed]
PHST- 2011/06/24 06:00 [medline]
PST - ppublish
SO  - Ann Acad Med Singap. 2011 Jan;40(1):1-3.


PMID- 21367768
OWN - NLM
STAT- MEDLINE
DCOM- 20110523
LR  - 20110318
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 4
DP  - 2011 Apr
TI  - Is there a right not to know one's sex? The ethics of 'gender verification' in
      women's sports competition.
PG  - 216-20
LID - 10.1136/jme.2010.039081 [doi]
AB  - The paper discusses the current medical practice of 'gender verification' in
      sports from an ethical point of view. It takes the recent public discussion about
      800&emsp14;m runner Caster Semenya as a starting point. At the World
      Championships in Athletics 2009 in Berlin, Germany, Semenya was challenged by
      competitors as being a so called 'sex impostor'. A medical examination to verify 
      her sex ensued. The author analyses whether athletes like Semenya could claim a
      right not to know that is generally acknowledged in human genetics and enforced
      by international and national genetic privacy laws. The relevance of this right
      for genetic diagnosis in sports is discussed. To this end, the interests of the
      athlete concerned and of third parties are balanced according to the expected
      benefits and harms.Harm is documented in a number of cases and includes
      unjustified disqualification, severe sex and gender identity crisis, demeaning
      reactions, social isolation, depression and suicide. Benefits are dubious as most
      cases of intersex are considered irrelevant for sports competition. It has to be 
      concluded that the benefits to be gained from 'gender verification' in sports via
      genetic testing do not outweigh the grave individual disadvantages. The current
      practice of athletic associations to largely ignore the right of competitors not 
      to know does not comply with prevailing ethical provisions on the protection of
      sensitive personal data. Therefore, genetic 'gender verification' in sports
      should be abolished.
FAU - Wiesemann, Claudia
AU  - Wiesemann C
AD  - Department of Medical Ethics and History of Medicine, Goettingen University
      Medical Center, Humboldtallee 36, 37073 Goettingen, Germany. cwiesem@gwdg.de
LA  - eng
PT  - Journal Article
DEP - 20110301
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Disorders of Sex Development/*diagnosis/psychology
MH  - Female
MH  - Genetic Counseling
MH  - Humans
MH  - Male
MH  - *Sex Characteristics
MH  - Sex Determination Analysis/*ethics
MH  - Sports/*ethics/legislation & jurisprudence
MH  - Truth Disclosure/*ethics
EDAT- 2011/03/04 06:00
MHDA- 2011/05/24 06:00
CRDT- 2011/03/04 06:00
PHST- 2011/03/04 06:00 [entrez]
PHST- 2011/03/04 06:00 [pubmed]
PHST- 2011/05/24 06:00 [medline]
AID - jme.2010.039081 [pii]
AID - 10.1136/jme.2010.039081 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Apr;37(4):216-20. doi: 10.1136/jme.2010.039081. Epub 2011 Mar 
      1.


PMID- 21367682
OWN - NLM
STAT- MEDLINE
DCOM- 20111209
LR  - 20110711
IS  - 1872-9177 (Electronic)
IS  - 1769-7255 (Linking)
VI  - 7
IP  - 4
DP  - 2011 Jul
TI  - [Physician-patient communication in nephrology].
PG  - 201-6
LID - 10.1016/j.nephro.2011.01.009 [doi]
AB  - Training the nephrologist-to-be to physician-patient communication (PPC) has
      several objectives: to guide his/her history taking in order to make a diagnosis,
      of course, but also to help him/her establish a long-lasting relationship, inform
      and motivate the patient, and prepare him/her to break bad news and to deal with 
      end-of-life issues. PPC rests on specific strategies and on the ethical grounds
      of a human encounter, the success of which expresses itself in care. An effective
      PPC offers many benefits to the patient, but also to the clinician. Talking about
      renal failure and dialysis, about kidney transplantation, and about withdrawing
      or not starting therapy: these are a few of the communicational challenges
      awaiting the nephrologist in training, mostly with patients requiring long-term
      follow-up. PPC also requires specific skills in the field of pediatric
      nephrology, where one deals alternately with children, adolescents and parents.
      Whatever the personal abilities of the nephrologist-to-be, PPC is a competency
      that can be learned and improved, for the benefit of the patient, and also of the
      physician.
CI  - Copyright (c) 2011 Association Societe de nephrologie. Published by Elsevier SAS.
      All rights reserved.
FAU - Querin, Serge
AU  - Querin S
AD  - Service de nephrologie, hopital du Sacre-Coeur de Montreal, 5400, boulevard Gouin
      Ouest, Montreal, Quebec, H4J 1C5 Canada. serge.querin@umontreal.ca
FAU - Clermont, Marie-Jose
AU  - Clermont MJ
FAU - Dupre-Goudable, Catherine
AU  - Dupre-Goudable C
FAU - Dalmon, Pauline
AU  - Dalmon P
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - La communication medecin-malade en nephrologie.
DEP - 20110302
PL  - France
TA  - Nephrol Ther
JT  - Nephrologie & therapeutique
JID - 101248950
SB  - IM
MH  - *Clinical Competence
MH  - Humans
MH  - *Information Dissemination
MH  - Kidney Transplantation
MH  - *Nephrology/education
MH  - Palliative Care
MH  - *Patient Education as Topic
MH  - *Physician-Patient Relations
MH  - Renal Dialysis
MH  - Renal Insufficiency/therapy
MH  - Risk Factors
EDAT- 2011/03/04 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/03/04 06:00
PHST- 2010/04/03 00:00 [received]
PHST- 2011/01/26 00:00 [revised]
PHST- 2011/01/26 00:00 [accepted]
PHST- 2011/03/04 06:00 [entrez]
PHST- 2011/03/04 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - S1769-7255(11)00045-9 [pii]
AID - 10.1016/j.nephro.2011.01.009 [doi]
PST - ppublish
SO  - Nephrol Ther. 2011 Jul;7(4):201-6. doi: 10.1016/j.nephro.2011.01.009. Epub 2011
      Mar 2.


PMID- 21367558
OWN - NLM
STAT- MEDLINE
DCOM- 20110718
LR  - 20191210
IS  - 1097-6809 (Electronic)
IS  - 0741-5214 (Linking)
VI  - 53
IP  - 5
DP  - 2011 May
TI  - Health care trends and vascular specialists: the good, the bad, and the ugly.
PG  - 1439-45
LID - 10.1016/j.jvs.2010.12.035 [doi]
AB  - Current health care trends include movements toward general health care reform
      and rapidly evolving changes affecting treatment of vascular disease.
      Government-sponsored programs and private coalitions increasingly influence
      practice management and patient care. Emerging organizational influences derive
      from public perceptions, policies, laws, and regulations intended to make health 
      care safe, effective, patient centered, timely, efficient, and equitable. These
      trends energized methods of quality assessment, cost containment, and practice
      protocols over individual judgments and seek to exert increasing direction over
      clinical practice. Some evolving measures are good, some controversial, and some,
      without deliberate intent, may be harmful. This review considers evolving
      initiatives in the context of ethics of practice and practicalities of managing
      patients with vascular disease. Key issues include compliance with purely
      process-based measures, pay for performance, and assessment of quality outcomes. 
      Strengths, weaknesses, opportunities, and potential threats to vascular practice 
      are outlined.
CI  - Copyright (c) 2011. Published by Mosby, Inc.
FAU - Depalma, Ralph G
AU  - Depalma RG
AD  - Department of Veterans Affairs, Office of Research and Development, Washington,
      DC, USA. ralph.depalma@va.gov
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110302
PL  - United States
TA  - J Vasc Surg
JT  - Journal of vascular surgery
JID - 8407742
SB  - IM
MH  - Evidence-Based Medicine/trends
MH  - Health Care Reform/economics/ethics/legislation & jurisprudence/*trends
MH  - Humans
MH  - Outcome and Process Assessment, Health Care/trends
MH  - Practice Management, Medical/economics/ethics/legislation & jurisprudence/*trends
MH  - Private Sector/trends
MH  - Public Opinion
MH  - Public Sector/trends
MH  - Quality of Health Care/trends
MH  - Reimbursement, Incentive/trends
MH  - Vascular Surgical Procedures/economics/ethics/legislation & jurisprudence/*trends
EDAT- 2011/03/04 06:00
MHDA- 2011/07/19 06:00
CRDT- 2011/03/04 06:00
PHST- 2010/12/03 00:00 [received]
PHST- 2010/12/06 00:00 [revised]
PHST- 2010/12/06 00:00 [accepted]
PHST- 2011/03/04 06:00 [entrez]
PHST- 2011/03/04 06:00 [pubmed]
PHST- 2011/07/19 06:00 [medline]
AID - S0741-5214(10)03055-7 [pii]
AID - 10.1016/j.jvs.2010.12.035 [doi]
PST - ppublish
SO  - J Vasc Surg. 2011 May;53(5):1439-45. doi: 10.1016/j.jvs.2010.12.035. Epub 2011
      Mar 2.


PMID- 21366145
OWN - NLM
STAT- MEDLINE
DCOM- 20110329
LR  - 20111117
IS  - 0198-7097 (Print)
IS  - 0198-7097 (Linking)
VI  - 33
IP  - 1
DP  - 2011 Jan-Feb
TI  - Corporate social responsibility of future radiology professionals.
PG  - 40-3
AB  - Plagued by difficult economic times, many radiology managers may find themselves 
      faced with ethical dilemmas surrounding ongoing organizational pressures to
      maintain high levels of productivity with restricted resources. This often times 
      tests the level of moral resilience and corporate social consciousness of even
      the most experienced radiology professionals. A study was conducted to determine 
      what Corporate Social Responsibility (CSR) orientation and viewpoint future
      radiology professionals may have. The results of the study indicate that these
      study participants may initially consider patient care more important than profit
      maximization. Study results indicate that these specific future radiology
      professionals will not need laws, legal sanctions, and intensified rules to force
      them to act ethically. However,they may need ongoing training as to the necessity
      of profit maximization if they seek the highest quality of care possible for
      their patients.
FAU - Collins, Sandra K
AU  - Collins SK
AD  - Southern Illinois University, Carbondale, USA. skcollin@siu.edu
FAU - Collins, Kevin S
AU  - Collins KS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Radiol Manage
JT  - Radiology management
JID - 8001971
MH  - Humans
MH  - Medical Laboratory Personnel/*ethics
MH  - Organizational Policy
MH  - Radiology Department, Hospital/economics/*organization & administration
MH  - *Social Responsibility
EDAT- 2011/03/04 06:00
MHDA- 2011/03/30 06:00
CRDT- 2011/03/04 06:00
PHST- 2011/03/04 06:00 [entrez]
PHST- 2011/03/04 06:00 [pubmed]
PHST- 2011/03/30 06:00 [medline]
PST - ppublish
SO  - Radiol Manage. 2011 Jan-Feb;33(1):40-3.


PMID- 21365474
OWN - NLM
STAT- MEDLINE
DCOM- 20120919
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 18
IP  - 2
DP  - 2012 Jun
TI  - A tale of two perspectives: regulation versus self-regulation. A financial
      reporting approach (from Sarbanes-Oxley) for research ethics.
PG  - 241-6
LID - 10.1007/s11948-011-9260-8 [doi]
AB  - Reports of research fraud have raised concerns about research integrity similar
      to concerns raised about financial accounting fraud. We propose a departure from 
      self-regulation in that researchers adopt the financial accounting approach in
      establishing trust through an external validation process, in addition to the
      reporting entities and the regulatory agencies. The general conceptual framework 
      for reviewing financial reports, utilizes external auditors who are certified and
      objective in using established standards to provide an opinion on the financial
      reports. These standards have become both broader in scope and increasingly
      specific as to what information is reported and the methodologies to be employed.
      We believe that the financial reporting overhaul encompassed in the US
      Sarbanes-Oxley Act of 2002, which aims at preventing accounting fraud, can be
      applied to scientific research in 4 ways. First, Sarbanes-Oxley requires
      corporations to have a complete set of internal accounting controls. Research
      organizations should use appropriate sampling techniques and audit research
      projects for conformity with the initial research protocols. Second, corporations
      are required to have the chief financial officer certify the accuracy of their
      financial statements. In a similar way, each research organization should have
      their vice-president of research (or equivalent) certify the research integrity
      of their research activities. In contrast, the primary responsibility of the
      existing Research Integrity Officers is to handle allegations of research
      misconduct, an after-the-fact activity. Third, generally accepted auditing
      standards specify the appropriate procedures for external review of a
      corporation's financial statements. For similar reasons, the research review
      process would also require corresponding external auditing standards. Finally,
      these new requirements would be implemented in stages, with the largest 14
      research organizations that receive 25% of the total National Institutes of
      Health funding, adopting these research oversight enhancements first.
FAU - Richman, Vincent
AU  - Richman V
AD  - School of Business and Economics, Sonoma State University, 1801 East Cotati
      Avenue, Rohnert Park, CA, 94928, USA. Vincent.Richman@Sonoma.edu
FAU - Richman, Alex
AU  - Richman A
LA  - eng
PT  - Journal Article
DEP - 20110302
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Ethics, Business
MH  - *Ethics, Research
MH  - Financial Audit
MH  - *Fraud
MH  - *Guidelines as Topic
MH  - Humans
MH  - Science/*ethics/standards
MH  - *Scientific Misconduct
MH  - *Trust
MH  - United States
EDAT- 2011/03/03 06:00
MHDA- 2012/09/20 06:00
CRDT- 2011/03/03 06:00
PHST- 2010/07/07 00:00 [received]
PHST- 2011/01/31 00:00 [accepted]
PHST- 2011/03/03 06:00 [entrez]
PHST- 2011/03/03 06:00 [pubmed]
PHST- 2012/09/20 06:00 [medline]
AID - 10.1007/s11948-011-9260-8 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2012 Jun;18(2):241-6. doi: 10.1007/s11948-011-9260-8. Epub 2011
      Mar 2.


PMID- 21365389
OWN - NLM
STAT- MEDLINE
DCOM- 20110907
LR  - 20211020
IS  - 2210-7711 (Electronic)
VI  - 33
IP  - 1
DP  - 2011 Feb
TI  - Review of paediatric gastrointestinal physiology data relevant to oral drug
      delivery.
PG  - 20-4
LID - 10.1007/s11096-010-9455-0 [doi]
AB  - AIM OF THE REVIEW: relatively new European Union regulations on children's
      medicines have emphasised the need for scientists to consider paediatric
      populations during drug development. This requires an understanding of the
      physiology in the paediatric population compared to that of adults. In this
      review, data cited in the public literature on the gastrointestinal (GI)
      physiology that could affect drug absorption have been summarised to draw
      attention to some of the differences between adults and paediatric populations
      that can make predicting the pharmacokinetics of oral drugs in the paediatric
      population a complex task. METHOD: a search for relevant articles was conducted
      using EMBASE, MEDLINE (through PubMed) and The National Institute for Public
      Health and the Environment. Additional journals were found from the references in
      the initial search results. Furthermore, a selection of common textbooks was used
      to fill in gaps in physiology data or understanding not covered by the journal
      articles found. Only data obtained from healthy individuals was used. RESULTS:
      information on the pH and transit time along the GI tract, as well as other GI
      physiology data was collated and summarised. There was less data available in the
      literature on the younger population partly as a consequence of the challenging
      ethics of carrying out invasive tests on healthy children. DISCUSSION AND
      CONCLUSION: it was found that considerable variability in physiology exists
      within the paediatric population. The pH and transit time of the GI tract varies 
      with age, with the greatest changes occurring during the neonate's first month.
      Other GI physiology also varies with age potentially having an impact on drug
      absorption. This review highlights the variability of paediatric physiological
      values within the literature, indicating the difficulty in performing
      measurements in the paediatric population as well as the natural variability that
      exists in this age group.
FAU - Kaye, Jonathan L
AU  - Kaye JL
AD  - GlaxoSmithKline Pharmaceuticals, Harlow South, New Frontiers Science Park,
      Harlow, Essex CM19 5AW, UK. Jonathan.L.Kaye@gsk.com
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110112
PL  - Netherlands
TA  - Int J Clin Pharm
JT  - International journal of clinical pharmacy
JID - 101554912
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Administration, Oral
MH  - Adolescent
MH  - Adult
MH  - Aging
MH  - Child
MH  - Child, Preschool
MH  - Drug and Narcotic Control
MH  - Gastrointestinal Tract/drug effects/*physiology
MH  - Gastrointestinal Transit
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Intestinal Absorption
MH  - Pharmaceutical Preparations/*administration & dosage
EDAT- 2011/03/03 06:00
MHDA- 2011/09/08 06:00
CRDT- 2011/03/03 06:00
PHST- 2010/08/18 00:00 [received]
PHST- 2010/11/09 00:00 [accepted]
PHST- 2011/03/03 06:00 [entrez]
PHST- 2011/03/03 06:00 [pubmed]
PHST- 2011/09/08 06:00 [medline]
AID - 10.1007/s11096-010-9455-0 [doi]
PST - ppublish
SO  - Int J Clin Pharm. 2011 Feb;33(1):20-4. doi: 10.1007/s11096-010-9455-0. Epub 2011 
      Jan 12.


PMID- 21365213
OWN - NLM
STAT- MEDLINE
DCOM- 20120313
LR  - 20211020
IS  - 1434-4726 (Electronic)
IS  - 0937-4477 (Linking)
VI  - 268
IP  - 12
DP  - 2011 Dec
TI  - Transoral robotic surgery for the management of head and neck tumors: learning
      curve.
PG  - 1795-801
LID - 10.1007/s00405-011-1537-7 [doi]
AB  - Transoral robotic surgery (TORS) is an emerging technique for the treatment of
      head and neck tumors. The objective of this study is to describe our first steps 
      and present our experience on the technical feasibility, safety, and efficacy of 
      TORS for the treatment of selected malignant lesions. From April 2008 to
      September 2009, 24 patients were enrolled in this prospective trial. Inclusion
      criteria were: adults with T1, T2 and selected T3 tumors involving the oral
      cavity, pharynx, and supraglottic larynx and a signed informed consent was
      obtained from the patient. Exclusion criteria were: tumors not accessible to TORS
      after unsuccessful attempts to expose properly the lesion to operate. The ethical
      committee's approval was obtained to perform this study. Twenty-four patients
      were included in this study: 10 supraglottic tumors, 10 pharyngeal tumors and 4
      oral cavity tumors. Nine patients had T1 tumors, 12 had T2 tumors, and 1 patient 
      had a T3 tumor. In all cases, tumor resection could be performed by robotic
      surgery exclusively and negative resection margins were achieved with control by 
      frozen section. None of them received intraoperative reconstruction. None of the 
      patients required tracheotomy. There was no intraoperative complication related
      to the use of the robot. The average setup time was 24 +/- 14 min (range 10-60
      min). The average surgical time was 67 +/- 46 min (range 12-180 min). Surgical
      and setup time decreased after the first cases. The mean hospital stay was 9
      days. Oral feeding was resumed at 3 days. TORS seems to be a safe, feasible,
      minimally invasive treatment modality for malignant head and neck tumors with a
      short learning curve for surgeons already experienced in endoscopic surgery.
FAU - Lawson, Georges
AU  - Lawson G
AD  - Otolaryngology-Head and Neck Surgery Department, Louvain University Hospital of
      Mont-Godinne, Dr Therasse Avenue No. 1, Yvoir, Belgium.
FAU - Matar, Nayla
AU  - Matar N
FAU - Remacle, Marc
AU  - Remacle M
FAU - Jamart, Jacques
AU  - Jamart J
FAU - Bachy, Vincent
AU  - Bachy V
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20110302
PL  - Germany
TA  - Eur Arch Otorhinolaryngol
JT  - European archives of oto-rhino-laryngology : official journal of the European
      Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the
      German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JID - 9002937
SB  - IM
MH  - Adult
MH  - Aged
MH  - Equipment Design
MH  - Feasibility Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Head and Neck Neoplasms/pathology/*surgery
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mouth
MH  - Natural Orifice Endoscopic Surgery/*methods
MH  - Neoplasm Staging
MH  - Otorhinolaryngologic Surgical Procedures/*instrumentation
MH  - Prospective Studies
MH  - Robotics/*instrumentation
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2011/03/03 06:00
MHDA- 2012/03/14 06:00
CRDT- 2011/03/03 06:00
PHST- 2010/12/01 00:00 [received]
PHST- 2011/02/07 00:00 [accepted]
PHST- 2011/03/03 06:00 [entrez]
PHST- 2011/03/03 06:00 [pubmed]
PHST- 2012/03/14 06:00 [medline]
AID - 10.1007/s00405-011-1537-7 [doi]
PST - ppublish
SO  - Eur Arch Otorhinolaryngol. 2011 Dec;268(12):1795-801. doi:
      10.1007/s00405-011-1537-7. Epub 2011 Mar 2.


PMID- 21364916
OWN - NLM
STAT- MEDLINE
DCOM- 20110901
LR  - 20211020
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 6
IP  - 2
DP  - 2011 Feb 25
TI  - Mode of effective connectivity within a putative neural network differentiates
      moral cognitions related to care and justice ethics.
PG  - e14730
LID - 10.1371/journal.pone.0014730 [doi]
AB  - BACKGROUND: Moral sensitivity refers to the interpretive awareness of moral
      conflict and can be justice or care oriented. Justice ethics is associated
      primarily with human rights and the application of moral rules, whereas care
      ethics is related to human needs and a situational approach involving social
      emotions. Among the core brain regions involved in moral issue processing are:
      medial prefrontal cortex, anterior (ACC) and posterior (PCC) cingulate cortex,
      posterior superior temporal sulcus (pSTS), insula and amygdala. This study sought
      to inform the long standing debate of whether care and justice moral ethics
      represent one or two different forms of cognition. METHODOLOGY/PRINCIPAL
      FINDINGS: Model-free and model-based connectivity analysis were used to identify 
      functional neural networks underlying care and justice ethics for a moral
      sensitivity task. In addition to modest differences in patterns of associated
      neural activity, distinct modes of functional and effective connectivity were
      observed for moral sensitivity for care and justice issues that were modulated by
      individual variation in moral ability. CONCLUSIONS/SIGNIFICANCE: These results
      support a neurobiological differentiation between care and justice ethics and
      suggest that human moral behavior reflects the outcome of integrating opposing
      rule-based, self-other perspectives, and emotional responses.
FAU - Caceda, Ricardo
AU  - Caceda R
AD  - Department of Psychiatry and Behavioral Sciences, Emory University School of
      Medicine, Atlanta, Georgia, United States of America.
FAU - James, G Andrew
AU  - James GA
FAU - Ely, Timothy D
AU  - Ely TD
FAU - Snarey, John
AU  - Snarey J
FAU - Kilts, Clinton D
AU  - Kilts CD
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110225
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adult
MH  - Cognition/*physiology
MH  - Efficiency
MH  - Empathy/ethics/*physiology
MH  - Humans
MH  - Judgment/physiology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Models, Neurological
MH  - *Morals
MH  - Nerve Net/*physiology
MH  - Social Justice/*ethics/*psychology
PMC - PMC3045376
EDAT- 2011/03/03 06:00
MHDA- 2011/09/02 06:00
CRDT- 2011/03/03 06:00
PHST- 2009/11/12 00:00 [received]
PHST- 2010/12/01 00:00 [accepted]
PHST- 2011/03/03 06:00 [entrez]
PHST- 2011/03/03 06:00 [pubmed]
PHST- 2011/09/02 06:00 [medline]
AID - 10.1371/journal.pone.0014730 [doi]
PST - epublish
SO  - PLoS One. 2011 Feb 25;6(2):e14730. doi: 10.1371/journal.pone.0014730.


PMID- 21364270
OWN - NLM
STAT- MEDLINE
DCOM- 20120117
LR  - 20220408
IS  - 1108-7161 (Print)
IS  - 1108-7161 (Linking)
VI  - 11
IP  - 1
DP  - 2011 Mar
TI  - What do we currently know from in vivo bone strain measurements in humans?
PG  - 8-20
AB  - Bone strains are the most important factors for osteogenic adaptive responses.
      During the past decades, scientists have been trying to describe the relationship
      between bone strain and bone osteogenic responses quantitatively. However, only a
      few studies have examined bone strains under physiological condition in humans,
      owing to technical difficulty and ethical restrictions. The present paper reviews
      previous work on in vivo bone strain measurements in humans, and the various
      methodologies adopted in these measurements are discussed. Several proposals are 
      made for future work to improve our understanding of the human musculoskeletal
      system. Literature suggests that strains and strain patterns vary systematically 
      in response to different locomotive activities, foot wear, and even different
      venues. The principal compressive, tension and engineering shear strain,
      compressive strain rate and shear strain rate in the tibia during running seem to
      be higher than those during walking. The high impact exercises, such as zig-zag
      hopping and basketball rebounding induced greater principal strains and strain
      rates in the tibia than normal activities. Also, evidence suggests an increase of
      tibia strain and strain rate after muscle fatigue, which strongly supports the
      opinion that muscle contractions play a role on the alteration of bone strain
      patterns.
FAU - Yang, P F
AU  - Yang PF
AD  - Division Space Physiology, Institute of Aerospace Medicine, German Aerospace
      Center, Cologne, Germany. Pengfei.Yang@dlr.de
FAU - Bruggemann, G-P
AU  - Bruggemann GP
FAU - Rittweger, J
AU  - Rittweger J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Greece
TA  - J Musculoskelet Neuronal Interact
JT  - Journal of musculoskeletal & neuronal interactions
JID - 101084496
SB  - IM
MH  - Bioengineering/instrumentation/*methods/trends
MH  - Biomechanical Phenomena/*physiology
MH  - Bone and Bones/*physiology
MH  - Humans
MH  - *Stress, Mechanical
EDAT- 2011/03/03 06:00
MHDA- 2012/01/18 06:00
CRDT- 2011/03/03 06:00
PHST- 2011/03/03 06:00 [entrez]
PHST- 2011/03/03 06:00 [pubmed]
PHST- 2012/01/18 06:00 [medline]
PST - ppublish
SO  - J Musculoskelet Neuronal Interact. 2011 Mar;11(1):8-20.


PMID- 21364083
OWN - NLM
STAT- MEDLINE
DCOM- 20110811
LR  - 20151119
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 259
IP  - 3
DP  - 2011 Jun
TI  - Analysis of gadobenate dimeglumine-enhanced MR findings for characterizing small 
      (1-2-cm) hepatic nodules in patients at high risk for hepatocellular carcinoma.
PG  - 730-8
LID - 10.1148/radiol.11101549 [doi]
AB  - PURPOSE: To retrospectively identify magnetic resonance (MR) imaging findings
      that are associated with hepatocellular carcinoma (HCC) in 1-2-cm nodules
      detected at surveillance ultrasonography (US) and to propose newer MR imaging
      diagnostic criteria. MATERIALS AND METHODS: Institutional research ethics board
      approval was obtained, and informed patient consent was waived. Among 145
      consecutive patients who had 1-2-cm nodules that were newly detected at
      surveillance US, 108 patients underwent gadobenate dimeglumine-enhanced MR
      imaging. After excluding hemangiomas and unconfirmed nodules, the study sample
      comprised 96 patients with 116 nodules, including 43 HCCs and 73 benign nodules. 
      MR imaging findings were assessed for signal intensity at each sequence. On the
      basis of the results of univariate and multivariable logistic regression
      analyses, several diagnostic criteria were developed by using combinations of MR 
      imaging findings, which were then compared with the American Association for the 
      Study of Liver Diseases (AASLD) practice guideline. RESULTS: Univariate analysis 
      revealed four imaging findings associated with HCC, including arterial phase
      hyperintensity, portal or delayed phase hypointensity (washout), hyperintensity
      on T2-weighted images, and hepatobiliary phase hypointensity (P < .001 for each).
      In the multivariable analysis, arterial phase hyperintensity (adjusted odds ratio
      [OR], 17.1; P = .003) and washout (adjusted OR, 11.7; P = .007) were associated
      with HCC. Of the developed criteria, the criteria including nodules fitting the
      AASLD practice guideline (arterial phase hyperintensity and washout) or nodules
      having three or more findings were considered most reasonable, showing improved
      sensitivity (77% [33 of 43] versus 67% [29 of 43], P = .048) and comparable
      specificity (95% [69 of 73] versus 99% [72 of 73], P = .09), as compared with
      AASLD practice guideline. CONCLUSION: Alternative MR imaging criteria for
      diagnosing HCC in 1-2-cm nodules detected at surveillance US that can improve
      sensitivity compared with the AASLD practice guideline were proposed. A larger
      study is needed to verify the preliminary criteria in this study. SUPPLEMENTAL
      MATERIAL:
      http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.11101549/-/DC1.
CI  - RSNA, 2011
FAU - Kim, Tae Kyoung
AU  - Kim TK
AD  - Department of Medical Imaging, University of Toronto, Toronto General Hospital,
      585 University Ave, Toronto, ON, Canada M5G 2N2. taekyoung.kim@uhn.on.ca
FAU - Lee, Kyoung Ho
AU  - Lee KH
FAU - Jang, Hyun-Jung
AU  - Jang HJ
FAU - Haider, Masoom A
AU  - Haider MA
FAU - Jacks, Lindsay M
AU  - Jacks LM
FAU - Menezes, Ravi J
AU  - Menezes RJ
FAU - Park, Seong Ho
AU  - Park SH
FAU - Yazdi, Leyla
AU  - Yazdi L
FAU - Sherman, Morris
AU  - Sherman M
FAU - Khalili, Korosh
AU  - Khalili K
LA  - eng
PT  - Journal Article
DEP - 20110301
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 15G12L5X8K (gadobenic acid)
RN  - 6HG8UB2MUY (Meglumine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Hepatocellular/*diagnosis/pathology
MH  - *Contrast Media
MH  - Female
MH  - Humans
MH  - Liver Neoplasms/*diagnosis/pathology
MH  - Logistic Models
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Meglumine/*analogs & derivatives
MH  - Middle Aged
MH  - *Organometallic Compounds
MH  - Population Surveillance
MH  - Practice Guidelines as Topic
MH  - Predictive Value of Tests
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
EDAT- 2011/03/03 06:00
MHDA- 2011/08/13 06:00
CRDT- 2011/03/03 06:00
PHST- 2011/03/03 06:00 [entrez]
PHST- 2011/03/03 06:00 [pubmed]
PHST- 2011/08/13 06:00 [medline]
AID - radiol.11101549 [pii]
AID - 10.1148/radiol.11101549 [doi]
PST - ppublish
SO  - Radiology. 2011 Jun;259(3):730-8. doi: 10.1148/radiol.11101549. Epub 2011 Mar 1.


PMID- 21364011
OWN - NLM
STAT- MEDLINE
DCOM- 20110615
LR  - 20161020
IS  - 1526-3347 (Electronic)
IS  - 0191-9601 (Linking)
VI  - 32
IP  - 3
DP  - 2011 Mar
TI  - Ethics for the pediatrician: providing culturally effective health care.
PG  - e39-43
LID - 10.1542/pir.32-3-e39 [doi]
FAU - Swota, Alissa Hurwitz
AU  - Swota AH
AD  - Department of Philosophy, University of North Florida, USA.
FAU - Hester, D Micah
AU  - Hester DM
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Pediatr Rev
JT  - Pediatrics in review
JID - 8103046
SB  - IM
MH  - Child
MH  - Communication Barriers
MH  - Cultural Competency/*ethics
MH  - Diabetes Mellitus, Type 1/drug therapy
MH  - Humans
MH  - Informed Consent/ethics
MH  - Male
MH  - Patient Participation
MH  - Pediatrics/*ethics
MH  - Persons With Hearing Impairments
MH  - Physician-Patient Relations
MH  - Translating
EDAT- 2011/03/03 06:00
MHDA- 2011/06/16 06:00
CRDT- 2011/03/03 06:00
PHST- 2011/03/03 06:00 [entrez]
PHST- 2011/03/03 06:00 [pubmed]
PHST- 2011/06/16 06:00 [medline]
AID - 32/3/e39 [pii]
AID - 10.1542/pir.32-3-e39 [doi]
PST - ppublish
SO  - Pediatr Rev. 2011 Mar;32(3):e39-43. doi: 10.1542/pir.32-3-e39.


PMID- 21362731
OWN - NLM
STAT- MEDLINE
DCOM- 20111007
LR  - 20141120
IS  - 1569-9285 (Electronic)
IS  - 1569-9285 (Linking)
VI  - 12
IP  - 6
DP  - 2011 Jun
TI  - Comparative study of the non-dependent continuous positive pressure ventilation
      and high-frequency positive-pressure ventilation during one-lung ventilation for 
      video-assisted thoracoscopic surgery.
PG  - 899-902
LID - 10.1510/icvts.2010.264911 [doi]
AB  - The application of volume controlled high-frequency positive-pressure ventilation
      (HFPPV) to the non-dependent lung (NL) may have comparable effects to continuous 
      positive-airway pressure (CPAP) on the surgical conditions during one-lung
      ventilation (OLV) for video-assisted thoracoscopic surgery (VATS). After local
      Ethics Committee approval and informed consent, we randomly allocated 30 patients
      scheduled for elective VATS after the first 15 min of OLV to ventilate the NL
      with CPAP of 2 cm H(2)O (NL-CPAP(2)) and HFPPV using tidal volume 2 ml/kg,
      inspiratory to expiratory ratio <0.3 and respiratory rate 60/min (NL-HFPPV) for
      30 min, each in a randomized crossover order. Intraoperative adequacy of surgical
      conditions was evaluated using a visual analog scale and the changes in
      hemodynamic and arterial oxygen were recorded. The application of NL-CPAP(2) and 
      NL-HFPPV resulted in more improved arterial oxygenation than during OLV for VATS 
      (P<0.001). The operative field was much better during the application of
      NL-CPAP(2) than during NL-HFPPV (P<0.001). We concluded that the application of
      CPAP to the NL during OLV offers good quality of operative field and improved
      arterial oxygenation for VATS.
FAU - El-Tahan, Mohamed R
AU  - El-Tahan MR
AD  - Department of Anaesthesia and Surgical Intensive Care Unit, King Fahd Hospital of
      the University of Dammam, Al Khubar, Saudi Arabia. mohamedrefaateltahan@yahoo.com
FAU - El Ghoneimy, Yasser F
AU  - El Ghoneimy YF
FAU - Regal, Mohamed A
AU  - Regal MA
FAU - El Emam, Hatem
AU  - El Emam H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20110301
PL  - England
TA  - Interact Cardiovasc Thorac Surg
JT  - Interactive cardiovascular and thoracic surgery
JID - 101158399
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Analysis of Variance
MH  - *Continuous Positive Airway Pressure
MH  - Cross-Over Studies
MH  - Elective Surgical Procedures
MH  - Female
MH  - Forced Expiratory Volume
MH  - Hemodynamics
MH  - *High-Frequency Ventilation
MH  - Humans
MH  - Lung/*physiology
MH  - Male
MH  - Middle Aged
MH  - Monitoring, Intraoperative
MH  - Oxygen/blood
MH  - Prospective Studies
MH  - Respiratory Mechanics
MH  - Saudi Arabia
MH  - *Thoracic Surgery, Video-Assisted
MH  - Tidal Volume
MH  - Vital Capacity
MH  - Young Adult
EDAT- 2011/03/03 06:00
MHDA- 2011/10/08 06:00
CRDT- 2011/03/03 06:00
PHST- 2011/03/03 06:00 [entrez]
PHST- 2011/03/03 06:00 [pubmed]
PHST- 2011/10/08 06:00 [medline]
AID - icvts.2010.264911 [pii]
AID - 10.1510/icvts.2010.264911 [doi]
PST - ppublish
SO  - Interact Cardiovasc Thorac Surg. 2011 Jun;12(6):899-902. doi:
      10.1510/icvts.2010.264911. Epub 2011 Mar 1.


PMID- 21362691
OWN - NLM
STAT- MEDLINE
DCOM- 20110908
LR  - 20181201
IS  - 1743-0593 (Electronic)
IS  - 1743-0585 (Linking)
VI  - 96
IP  - 3
DP  - 2011 Jun
TI  - Analgosedation in neonates: do we still need additional tools after 30 years of
      clinical research?
PG  - 112-8
LID - 10.1136/adc.2008.145565 [doi]
AB  - Approximately 30 years ago, the myth that nervous system immaturity precluded
      neonates from pain perception and its negative effects was rejected.
      Neurobiologists further explored neurodevelopmental nociception. These
      observations strongly suggest that early pain experience contributes to
      neurodevelopmental outcome, pain thresholds, pain or stress-related behaviour and
      physiological responses in later life. Effective management of pain therefore
      remains an important indicator of the quality of care provided to neonates, not
      only from an ethical, but also from a short and long-term outcome perspective.
      Simultaneously, neonatal care itself has changed and data on neuro-apoptosis and 
      impaired synaptogenesis following exposure to analgosedatives emerged. When
      developmental pharmacology concepts are applied to neonatal analgosedation, this 
      means that this should be based on systematic assessment, followed by titrated
      administration of the most appropriate analgesic(s) with subsequent re-assessment
      to adapt treatment. This review will focus on the limitations of the available
      assessment tools, newly emerging analgosedatives in neonates to illustrate how
      these compounds can be integrated into the changing concepts of neonatal care.
FAU - Thewissen, Liesbeth
AU  - Thewissen L
AD  - Neonatal Intensive Care Unit, Division of Woman and Child, University Hospital,
      Gasthuisberg, Herestraat, Leuven, Belgium.
FAU - Allegaert, Karel
AU  - Allegaert K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110228
PL  - England
TA  - Arch Dis Child Educ Pract Ed
JT  - Archives of disease in childhood. Education and practice edition
JID - 101220684
RN  - 0 (Adrenergic alpha-2 Receptor Agonists)
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Hypnotics and Sedatives)
RN  - 0 (Piperidines)
RN  - 362O9ITL9D (Acetaminophen)
RN  - 67VB76HONO (Dexmedetomidine)
RN  - 76I7G6D29C (Morphine)
RN  - P10582JYYK (Remifentanil)
RN  - R60L0SM5BC (Midazolam)
RN  - YI7VU623SF (Propofol)
SB  - IM
MH  - Acetaminophen/pharmacology
MH  - Adrenergic alpha-2 Receptor Agonists/pharmacology
MH  - Analgesia/*methods
MH  - Analgesics, Opioid/therapeutic use
MH  - Dexmedetomidine/pharmacology
MH  - Humans
MH  - Hypnotics and Sedatives/*pharmacology
MH  - Infant, Newborn
MH  - Midazolam/pharmacology
MH  - Morphine/pharmacology
MH  - Pain/*prevention & control
MH  - Pain Measurement
MH  - Piperidines/pharmacology
MH  - Propofol/pharmacology
MH  - Quality of Health Care
MH  - Remifentanil
EDAT- 2011/03/03 06:00
MHDA- 2011/09/09 06:00
CRDT- 2011/03/03 06:00
PHST- 2011/03/03 06:00 [entrez]
PHST- 2011/03/03 06:00 [pubmed]
PHST- 2011/09/09 06:00 [medline]
AID - adc.2008.145565 [pii]
AID - 10.1136/adc.2008.145565 [doi]
PST - ppublish
SO  - Arch Dis Child Educ Pract Ed. 2011 Jun;96(3):112-8. doi: 10.1136/adc.2008.145565.
      Epub 2011 Feb 28.


PMID- 21362653
OWN - NLM
STAT- MEDLINE
DCOM- 20110421
LR  - 20170519
IS  - 1931-3543 (Electronic)
IS  - 0012-3692 (Linking)
VI  - 139
IP  - 3
DP  - 2011 Mar
TI  - A brief historical and theoretical perspective on patient autonomy and medical
      decision making: Part I: The beneficence model.
PG  - 669-673
LID - S0012-3692(11)60136-0 [pii]
LID - 10.1378/chest.10-2532 [doi]
AB  - As part of a larger series addressing the intersection of law and medicine, this 
      essay is the first of two introductory pieces. This article explores the nature
      of the physician-patient relationship and of the practice of medicine dating from
      the Hippocratic tradition to the end of the 19th century, a period during which a
      beneficence-based medical ethic remained relatively stable. The medical
      literature dating from the Hippocratic texts to the early codes of the American
      Medical Association did not include a meaningful role for the patient in the
      decision-making process. In fact, the practice of benevolent deception--the
      deliberate withholding of any information thought by the physician to be
      detrimental to the patient's prognosis--was encouraged. However, as philosophers 
      identified an inherent value in respecting patient self-determination and the law
      imposed a duty on physicians to obtain informed consent, 2,400 years of relative 
      stability under the beneficence model gave way to the autonomy model.
FAU - Will, Jonathan F
AU  - Will JF
AD  - Bioethics and Health Law Center, Mississippi College School of Law, Jackson, MS. 
      Electronic address: will@mc.edu.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - Chest
JT  - Chest
JID - 0231335
SB  - IM
CIN - Chest. 2011 Mar;139(3):488-9. PMID: 21362649
MH  - American Medical Association/history
MH  - Decision Making/*ethics
MH  - *Decision Support Techniques
MH  - Ethics, Medical/*history
MH  - Hippocratic Oath
MH  - History, 15th Century
MH  - History, 16th Century
MH  - History, 17th Century
MH  - History, 18th Century
MH  - History, 19th Century
MH  - History, Ancient
MH  - History, Medieval
MH  - Humans
MH  - Patient Participation/history
MH  - Patient Rights/ethics/*history/legislation & jurisprudence
MH  - Physician-Patient Relations/ethics
MH  - Physicians/ethics/legislation & jurisprudence
MH  - Quality of Health Care/ethics/legislation & jurisprudence/standards
MH  - United States
EDAT- 2011/03/03 06:00
MHDA- 2011/04/22 06:00
CRDT- 2011/03/03 06:00
PHST- 2011/03/03 06:00 [entrez]
PHST- 2011/03/03 06:00 [pubmed]
PHST- 2011/04/22 06:00 [medline]
AID - S0012-3692(11)60136-0 [pii]
AID - 10.1378/chest.10-2532 [doi]
PST - ppublish
SO  - Chest. 2011 Mar;139(3):669-673. doi: 10.1378/chest.10-2532.


PMID- 21362649
OWN - NLM
STAT- MEDLINE
DCOM- 20110421
LR  - 20170519
IS  - 1931-3543 (Electronic)
IS  - 0012-3692 (Linking)
VI  - 139
IP  - 3
DP  - 2011 Mar
TI  - The interface of law and medicine: a new series in the "Medical Ethics" section.
PG  - 488-489
LID - S0012-3692(11)60111-6 [pii]
LID - 10.1378/chest.10-3177 [doi]
FAU - Manthous, Constantine A
AU  - Manthous CA
AD  - Bridgeport Hospital and Yale University School of Medicine, Bridgeport, CT.
      Electronic address: Pcmant@bpthosp.org.
FAU - Irwin, Richard S
AU  - Irwin RS
AD  - University of Massachusetts and the Editorial Office of CHEST, Worcester, MA.
LA  - eng
PT  - Comment
PT  - Editorial
PL  - United States
TA  - Chest
JT  - Chest
JID - 0231335
SB  - IM
CON - Chest. 2011 Mar;139(3):669-73. PMID: 21362653
MH  - Decision Support Techniques
MH  - *Ethics, Medical
MH  - Ethics, Professional
MH  - Humans
MH  - *Jurisprudence
MH  - *Medicine
MH  - Patient Rights/ethics/legislation & jurisprudence
MH  - Quality of Health Care/ethics/legislation & jurisprudence/standards
MH  - United States
EDAT- 2011/03/03 06:00
MHDA- 2011/04/22 06:00
CRDT- 2011/03/03 06:00
PHST- 2011/03/03 06:00 [entrez]
PHST- 2011/03/03 06:00 [pubmed]
PHST- 2011/04/22 06:00 [medline]
AID - S0012-3692(11)60111-6 [pii]
AID - 10.1378/chest.10-3177 [doi]
PST - ppublish
SO  - Chest. 2011 Mar;139(3):488-489. doi: 10.1378/chest.10-3177.


PMID- 21362099
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20110315
IS  - 1553-2712 (Electronic)
IS  - 1069-6563 (Linking)
VI  - 18
IP  - 3
DP  - 2011 Mar
TI  - Conflicts of interest in human subjects research: special considerations for
      academic emergency physicians.
PG  - 292-6
LID - 10.1111/j.1553-2712.2010.00998.x [doi]
AB  - Trust in the doctor-patient or investigator-subject relationship is vital to the 
      practice of medicine and advancement through biomedical research. Individual and 
      environmental factors can make this trust more difficult to establish in the
      emergency department (ED). To perform research ethically and maintain this trust,
      it is important to minimize and manage conflicts of interest in human subjects
      research. While principle-based ethics are an important starting point, the
      virtue of the individual investigator is required to assure that the interests
      and safety of research participants are prioritized over the interests of the
      investigator or the medical community at large. SAEM Ethics Committee 2009-2010
      Objective 4: "Based on the results of the didactic session presented at the
      annual meeting, develop a guide to assist SAEM members in the recognition of
      potential conflicts of interest in the practice of academic emergency medicine".
CI  - (c) 2011 by the Society for Academic Emergency Medicine.
FAU - Asher, Shellie L
AU  - Asher SL
AD  - Department of Emergency Medicine, Albany Medical College, Albany, NY, USA.
      AsherSh@mail.amc.edu
FAU - Schears, Raquel M
AU  - Schears RM
FAU - Miller, Chadwick D
AU  - Miller CD
LA  - eng
PT  - Journal Article
DEP - 20110301
PL  - United States
TA  - Acad Emerg Med
JT  - Academic emergency medicine : official journal of the Society for Academic
      Emergency Medicine
JID - 9418450
SB  - IM
MH  - *Conflict of Interest
MH  - Disclosure
MH  - Emergency Medicine/*ethics
MH  - Ethics Committees, Research
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - *Researcher-Subject Relations
EDAT- 2011/03/03 06:00
MHDA- 2011/07/27 06:00
CRDT- 2011/03/03 06:00
PHST- 2011/03/03 06:00 [entrez]
PHST- 2011/03/03 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
AID - 10.1111/j.1553-2712.2010.00998.x [doi]
PST - ppublish
SO  - Acad Emerg Med. 2011 Mar;18(3):292-6. doi: 10.1111/j.1553-2712.2010.00998.x. Epub
      2011 Mar 1.


PMID- 21362005
OWN - NLM
STAT- MEDLINE
DCOM- 20111220
LR  - 20191210
IS  - 1471-6712 (Electronic)
IS  - 0283-9318 (Linking)
VI  - 25
IP  - 3
DP  - 2011 Sep
TI  - Nurses' perceived work-related empowerment in Lithuanian context.
PG  - 599-607
LID - 10.1111/j.1471-6712.2011.00871.x [doi]
AB  - UNLABELLED: STUDY'S RATIONALE: Empowerment is widely used within the nursing
      literature in different countries, but perceived empowerment of Lithuanian nurses
      has not been studied before. There is a lack of research which has analysed
      nurses' views and feelings of empowerment. AIMS AND OBJECTIVES: The aim of this
      study was to describe the perception of Lithuanian nurses' work-related
      empowerment. The study describes how empowered the nurses felt in their work and 
      how background factors were related to empowerment. ETHICAL ISSUES: The
      permission to use the questionnaire was given by copyright holders. The
      questionnaire was approved by the Ethics Committee. RESEARCH METHODS AND
      INSTRUMENT: The data were collected using a structured questionnaire comprised of
      two parts: the background questions and the Work Empowerment Questionnaire
      divided into three areas: verbal, behavioural, and outcome empowerment. The data 
      were analysed statistically using SPSS, and Microsoft Excel programs. The
      descriptive statistics, non-parametric tests and Spearman correlations were
      conducted. The sample consisted of 212 participants. RESULTS: The nurses
      experienced strong general empowerment (mean 7.9; max 10.0). They were more
      confident in their abilities to perform actions related to behavioural (mean 8.3)
      and verbal (mean 8.0) empowerment, and less confident in outcome (mean 7.3)
      empowerment. All aspects of empowerment were closely related to each other (p </=
      0.001). Several significant relations were found between the aspects of
      empowerment and the background variables. STUDY LIMITATIONS: The Work Empowerment
      Questionnaire used in the study was originally developed in Canada. Differences
      in language, culture, health care organizations, and nursing practice may affect 
      the validity of translated questionnaire in Baltic context. CONCLUSIONS: To
      prepare nurses for roles in which they may successfully exercise the power to
      create change, they need experience the process of empowerment during their
      education, and experience later supportive management.
CI  - (c) 2011 The Authors. Scandinavian Journal of Caring Sciences (c) 2011 Nordic
      College of Caring Science.
FAU - Trus, Marija
AU  - Trus M
AD  - Faculty of Health Sciences, Klaipeda University, Klaipeda, Lithuania.
      marijatrush@gmail.com
FAU - Suominen, Tarja
AU  - Suominen T
FAU - Doran, Diane
AU  - Doran D
FAU - Razbadauskas, Arturas
AU  - Razbadauskas A
LA  - eng
PT  - Journal Article
DEP - 20110301
PL  - Sweden
TA  - Scand J Caring Sci
JT  - Scandinavian journal of caring sciences
JID - 8804206
MH  - Environmental Exposure
MH  - Humans
MH  - Lithuania
MH  - Nurses/*psychology
MH  - *Power, Psychological
EDAT- 2011/03/03 06:00
MHDA- 2011/12/21 06:00
CRDT- 2011/03/03 06:00
PHST- 2011/03/03 06:00 [entrez]
PHST- 2011/03/03 06:00 [pubmed]
PHST- 2011/12/21 06:00 [medline]
AID - 10.1111/j.1471-6712.2011.00871.x [doi]
PST - ppublish
SO  - Scand J Caring Sci. 2011 Sep;25(3):599-607. doi:
      10.1111/j.1471-6712.2011.00871.x. Epub 2011 Mar 1.


PMID- 21361892
OWN - NLM
STAT- MEDLINE
DCOM- 20120224
LR  - 20220410
IS  - 1541-0420 (Electronic)
IS  - 0006-341X (Linking)
VI  - 67
IP  - 3
DP  - 2011 Sep
TI  - Hierarchical commensurate and power prior models for adaptive incorporation of
      historical information in clinical trials.
PG  - 1047-56
LID - 10.1111/j.1541-0420.2011.01564.x [doi]
AB  - Bayesian clinical trial designs offer the possibility of a substantially reduced 
      sample size, increased statistical power, and reductions in cost and ethical
      hazard. However when prior and current information conflict, Bayesian methods can
      lead to higher than expected type I error, as well as the possibility of a
      costlier and lengthier trial. This motivates an investigation of the feasibility 
      of hierarchical Bayesian methods for incorporating historical data that are
      adaptively robust to prior information that reveals itself to be inconsistent
      with the accumulating experimental data. In this article, we present several
      models that allow for the commensurability of the information in the historical
      and current data to determine how much historical information is used. A primary 
      tool is elaborating the traditional power prior approach based upon a measure of 
      commensurability for Gaussian data. We compare the frequentist performance of
      several methods using simulations, and close with an example of a colon cancer
      trial that illustrates a linear models extension of our adaptive borrowing
      approach. Our proposed methods produce more precise estimates of the model
      parameters, in particular, conferring statistical significance to the observed
      reduction in tumor size for the experimental regimen as compared to the control
      regimen.
CI  - (c) 2011, The International Biometric Society.
FAU - Hobbs, Brian P
AU  - Hobbs BP
AD  - Department of Biostatistics, M.D. Anderson Cancer Center, Houston, Texas 77030,
      USA. bphobbs@mdanderson.org
FAU - Carlin, Bradley P
AU  - Carlin BP
FAU - Mandrekar, Sumithra J
AU  - Mandrekar SJ
FAU - Sargent, Daniel J
AU  - Sargent DJ
LA  - eng
GR  - R01 CA095955/CA/NCI NIH HHS/United States
GR  - U10-CA25224/CA/NCI NIH HHS/United States
GR  - U10 CA025224/CA/NCI NIH HHS/United States
GR  - R01 CA095955-07/CA/NCI NIH HHS/United States
GR  - R01-CA095955/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110301
PL  - United States
TA  - Biometrics
JT  - Biometrics
JID - 0370625
SB  - IM
MH  - *Bayes Theorem
MH  - Biometry/methods
MH  - Clinical Trials as Topic/*statistics & numerical data
MH  - Colonic Neoplasms
MH  - Humans
MH  - *Models, Statistical
MH  - Tumor Burden
PMC - PMC3134568
MID - NIHMS272506
EDAT- 2011/03/03 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/03/03 06:00
PHST- 2011/03/03 06:00 [entrez]
PHST- 2011/03/03 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - 10.1111/j.1541-0420.2011.01564.x [doi]
PST - ppublish
SO  - Biometrics. 2011 Sep;67(3):1047-56. doi: 10.1111/j.1541-0420.2011.01564.x. Epub
      2011 Mar 1.


PMID- 21360035
OWN - NLM
STAT- MEDLINE
DCOM- 20120608
LR  - 20211020
IS  - 1433-7339 (Electronic)
IS  - 0941-4355 (Linking)
VI  - 20
IP  - 3
DP  - 2012 Mar
TI  - Integrative oncology research in the Middle East: weaving traditional and
      complementary medicine in supportive care.
PG  - 557-64
LID - 10.1007/s00520-011-1121-0 [doi]
AB  - INTRODUCTION: Complementary and alternative medicine (CAM) has an important role 
      in supportive cancer care in the Middle East and is often used in association
      with traditional medicine. This article provides a comprehensive review of
      published data on CAM research in supportive cancer care in the Middle East.
      METHODS AND RESULTS: A multi-disciplinary Middle-Eastern Research Group in
      Integrative Oncology (MERGIO) was established in six countries. Authors
      independently searched Medline database for articles in Arabic, Hebrew, French,
      and Turkish using oncology and CAM-related keywords. Articles were recorded
      according to the first author's affiliation with an academic or clinical
      institution in the Middle East. RESULTS: We identified 143 articles on CAM and
      cancer care that had been published in 12 Middle-Eastern countries. Eighty-five
      articles were directly related to cancer supportive care. The latter included
      studies on the prevalence of CAM use by patients with cancer, aspects related to 
      of doctor-patient communication, ethics and regulation, psychosocial aspects of
      CAM, CAM safety and quality assurance, studies of CAM education for health care
      providers, and ethno-botanical studies and reviews. Twenty-eight articles
      referred to clinical research on supportive care, and the use of specific CAM
      modalities that included acupuncture, anthroposophic medicine, dietary and
      nutritional therapies herbal medicine, homeopathy, mind-body medicine, shiatsu,
      therapeutic touch, and yoga. CONCLUSIONS: CAM-related supportive care research is
      prevalent in the Middle East, a fact that may serve as a basis for future
      multinational-multidisciplinary research work in supportive care in oncology.
FAU - Ben-Arye, Eran
AU  - Ben-Arye E
AD  - Integrative Oncology Program, The Oncology Service and Lin Medical Center, Clalit
      Health Services, Haifa and Western Galilee District, 35 Rothschild St, Haifa,
      Israel 35152. eranben@netvision.net.il
FAU - Ali-Shtayeh, Mohammed Saleem
AU  - Ali-Shtayeh MS
FAU - Nejmi, Mati
AU  - Nejmi M
FAU - Schiff, Elad
AU  - Schiff E
FAU - Hassan, Esmat
AU  - Hassan E
FAU - Mutafoglu, Kamer
AU  - Mutafoglu K
FAU - Afifi, Fatma U
AU  - Afifi FU
FAU - Jamous, Rana Majed
AU  - Jamous RM
FAU - Lev, Efraim
AU  - Lev E
FAU - Silbermman, Michael
AU  - Silbermman M
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110301
PL  - Germany
TA  - Support Care Cancer
JT  - Supportive care in cancer : official journal of the Multinational Association of 
      Supportive Care in Cancer
JID - 9302957
SB  - IM
MH  - Humans
MH  - Integrative Medicine/*methods/statistics & numerical data
MH  - Islam
MH  - Medical Oncology/*methods
MH  - Medicine, Traditional/*methods/*statistics & numerical data
MH  - Middle East
MH  - Neoplasms/*therapy
MH  - Patient Preference
MH  - Physician-Patient Relations
EDAT- 2011/03/02 06:00
MHDA- 2012/06/09 06:00
CRDT- 2011/03/02 06:00
PHST- 2010/11/08 00:00 [received]
PHST- 2011/02/13 00:00 [accepted]
PHST- 2011/03/02 06:00 [entrez]
PHST- 2011/03/02 06:00 [pubmed]
PHST- 2012/06/09 06:00 [medline]
AID - 10.1007/s00520-011-1121-0 [doi]
PST - ppublish
SO  - Support Care Cancer. 2012 Mar;20(3):557-64. doi: 10.1007/s00520-011-1121-0. Epub 
      2011 Mar 1.


PMID- 21359908
OWN - NLM
STAT- MEDLINE
DCOM- 20110914
LR  - 20110520
IS  - 1554-3528 (Electronic)
IS  - 1554-351X (Linking)
VI  - 43
IP  - 2
DP  - 2011 Jun
TI  - The use of visual and automatized behavioral markers to assess methodologies: a
      study case on PIT-tagging in the Alpine newt.
PG  - 568-76
LID - 10.3758/s13428-011-0058-z [doi]
AB  - In various research fields, biomarkers are now widely used as tools for assessing
      individual integrity. The recent advances in quantification methods for
      behavioral patterns, such as computerized video-tracking procedures, make them
      valuable biomarkers. However, the corollary of these novelties is that they
      remain relatively unknown and unused. In this study, we show that such tools can 
      assess the validity of research methods, such as individual recognition. To
      demonstrate this, we employed, as a model, a marking method (passive integrated
      transponder [PIT] tagging) widely used in amphibians. Detailed visual
      observations and video-tracking methods were complementary in highlighting
      components at different behavioral scales: locomotion, feeding, and breeding. We 
      illustrate the scientific and ethical adequacy of the targeted marking method but
      also suggest that more studies should integrate behavioral analyses. Such
      biomarkers are a powerful tool for assessing conservation concerns when other
      techniques cannot detect detrimental effects.
FAU - Winandy, Laurane
AU  - Winandy L
AD  - Laboratory of Fish and Amphibian Ethology, Behavioural Biology Unit, Department
      of Environmental Sciences, University of Liege, 22 Quai van Beneden, 4020, Liege,
      Belgium. L.winandy@student.ulg.ac.be
FAU - Denoel, Mathieu
AU  - Denoel M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Behav Res Methods
JT  - Behavior research methods
JID - 101244316
SB  - IM
MH  - Animals
MH  - Behavior, Animal
MH  - Female
MH  - Male
MH  - *Research Design
MH  - Salamandridae
MH  - Telemetry/*methods
MH  - Video Recording/*methods
EDAT- 2011/03/02 06:00
MHDA- 2011/09/15 06:00
CRDT- 2011/03/02 06:00
PHST- 2011/03/02 06:00 [entrez]
PHST- 2011/03/02 06:00 [pubmed]
PHST- 2011/09/15 06:00 [medline]
AID - 10.3758/s13428-011-0058-z [doi]
PST - ppublish
SO  - Behav Res Methods. 2011 Jun;43(2):568-76. doi: 10.3758/s13428-011-0058-z.


PMID- 21359253
OWN - NLM
STAT- MEDLINE
DCOM- 20110606
LR  - 20110301
IS  - 1172-6156 (Electronic)
IS  - 1172-6156 (Linking)
VI  - 3
IP  - 1
DP  - 2011 Mar 1
TI  - The relativistic, naturalistic nature of ethics and other issues.
PG  - 2-3
FAU - Goodyear-Smith, Felicity
AU  - Goodyear-Smith F
LA  - eng
PT  - Editorial
PT  - Introductory Journal Article
DEP - 20110301
PL  - Australia
TA  - J Prim Health Care
JT  - Journal of primary health care
JID - 101524060
SB  - IM
MH  - *Bioethical Issues
MH  - Health Care Costs
MH  - Health Care Rationing/*ethics
MH  - Humans
MH  - Primary Health Care/economics
EDAT- 2011/03/02 06:00
MHDA- 2011/06/07 06:00
CRDT- 2011/03/02 06:00
PHST- 2011/03/02 06:00 [entrez]
PHST- 2011/03/02 06:00 [pubmed]
PHST- 2011/06/07 06:00 [medline]
PST - epublish
SO  - J Prim Health Care. 2011 Mar 1;3(1):2-3.


PMID- 21358180
OWN - NLM
STAT- MEDLINE
DCOM- 20110531
LR  - 20190710
IS  - 0065-3071 (Print)
IS  - 0065-3071 (Linking)
VI  - 70
DP  - 2011
TI  - Ordering genetic tests and interpreting the results.
PG  - 18-24
LID - 10.1159/000322466 [doi]
AB  - As the number of clinical genetic laboratories becomes more abundant, it will
      become increasingly challenging for clinicians in the medical and surgical
      specialties to navigate the vast menus of testing available and decide upon the
      most appropriate approach for molecular diagnosis of a particular disorder. There
      are many associated ethical and psychosocial issues involved with ordering
      clinical genetic tests of which practitioners need to remain aware, including
      predictive testing of minors, implications of the test result for other family
      members, theoretical risks of insurance or employment discrimination, and how to 
      appropriately counsel families once test results have been finalized and
      reported. Finally, as the field of genetic testing changes so rapidly, it will be
      of great help for otolaryngologists to familiarize themselves and remain up to
      date with the general terminology and interpretive criteria that go into clinical
      molecular genetic laboratory reports, in order to make it useful and
      understandable to clinicians and patients.
CI  - Copyright (c) 2011 S. Karger AG, Basel.
FAU - Deignan, Joshua L
AU  - Deignan JL
FAU - Grody, Wayne W
AU  - Grody WW
LA  - eng
PT  - Journal Article
DEP - 20110224
PL  - Switzerland
TA  - Adv Otorhinolaryngol
JT  - Advances in oto-rhino-laryngology
JID - 0242534
SB  - IM
MH  - Employment
MH  - Ethics, Medical
MH  - Genetic Counseling
MH  - Genetic Predisposition to Disease
MH  - *Genetic Privacy
MH  - *Genetic Testing
MH  - Humans
MH  - Informed Consent
MH  - Otorhinolaryngologic Diseases/*genetics
MH  - Prejudice
EDAT- 2011/03/02 06:00
MHDA- 2011/06/01 06:00
CRDT- 2011/03/02 06:00
PHST- 2011/03/02 06:00 [entrez]
PHST- 2011/03/02 06:00 [pubmed]
PHST- 2011/06/01 06:00 [medline]
AID - 000322466 [pii]
AID - 10.1159/000322466 [doi]
PST - ppublish
SO  - Adv Otorhinolaryngol. 2011;70:18-24. doi: 10.1159/000322466. Epub 2011 Feb 24.


PMID- 21357971
OWN - NLM
STAT- MEDLINE
DCOM- 20110531
LR  - 20211020
IS  - 1758-1095 (Electronic)
IS  - 0141-0768 (Linking)
VI  - 104
IP  - 3
DP  - 2011 Mar
TI  - Primary care ethics: a body of literature and a community of scholars?
PG  - 94-6
LID - 10.1258/jrsm.2010.100353 [doi]
FAU - Papanikitas, Andrew
AU  - Papanikitas A
FAU - Toon, Peter
AU  - Toon P
LA  - eng
PT  - Editorial
PL  - England
TA  - J R Soc Med
JT  - Journal of the Royal Society of Medicine
JID - 7802879
SB  - IM
MH  - General Practice/*education/*ethics
MH  - Humans
MH  - Primary Health Care/*ethics/*organization & administration
MH  - *State Medicine
MH  - United Kingdom
PMC - PMC3046200
EDAT- 2011/03/02 06:00
MHDA- 2011/06/01 06:00
CRDT- 2011/03/02 06:00
PHST- 2011/03/02 06:00 [entrez]
PHST- 2011/03/02 06:00 [pubmed]
PHST- 2011/06/01 06:00 [medline]
AID - 104/3/94 [pii]
AID - 10.1258/jrsm.2010.100353 [doi]
PST - ppublish
SO  - J R Soc Med. 2011 Mar;104(3):94-6. doi: 10.1258/jrsm.2010.100353.


PMID- 21357869
OWN - NLM
STAT- MEDLINE
DCOM- 20110712
LR  - 20190709
IS  - 1943-4723 (Electronic)
IS  - 0002-8177 (Linking)
VI  - 142
IP  - 3
DP  - 2011 Mar
TI  - Is providing onabotulinumtoxina or similar injections ethical?
PG  - 335-7
FAU - Henner, Kevin A
AU  - Henner KA
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Am Dent Assoc
JT  - Journal of the American Dental Association (1939)
JID - 7503060
RN  - 0 (Neuromuscular Agents)
RN  - EC 3.4.24.69 (Botulinum Toxins, Type A)
SB  - IM
CIN - J Am Dent Assoc. 2011 Sep;142(9):999-1002; author reply 1002-3. PMID: 21881063
MH  - Botulinum Toxins, Type A/administration & dosage
MH  - Cosmetic Techniques/*ethics
MH  - Dentists/*ethics
MH  - *Ethics, Dental
MH  - Humans
MH  - Injections, Intramuscular/ethics
MH  - Neuromuscular Agents/administration & dosage
EDAT- 2011/03/02 06:00
MHDA- 2011/07/13 06:00
CRDT- 2011/03/02 06:00
PHST- 2011/03/02 06:00 [entrez]
PHST- 2011/03/02 06:00 [pubmed]
PHST- 2011/07/13 06:00 [medline]
AID - S0002-8177(14)62046-8 [pii]
AID - 10.14219/jada.archive.2011.0175 [doi]
PST - ppublish
SO  - J Am Dent Assoc. 2011 Mar;142(3):335-7. doi: 10.14219/jada.archive.2011.0175.


PMID- 21357796
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20110524
IS  - 1538-3679 (Electronic)
IS  - 0003-9926 (Linking)
VI  - 171
IP  - 10
DP  - 2011 May 23
TI  - Optimism amid serious disease: clinical panacea or ethical conundrum?: comment on
      "Recovery expectations and long-term prognosis of patients with coronary heart
      disease".
PG  - 935-6
LID - 10.1001/archinternmed.2011.40 [doi]
FAU - Gramling, Robert
AU  - Gramling R
AD  - Family Medicine Research and Centers for Ethics, Medical Humanities and
      Palliative Care, University of Rochester, NY 14620, USA.
      Robert_Gramling@URMC.Rochester.edu
FAU - Epstein, Ronald
AU  - Epstein R
LA  - eng
PT  - Comment
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110228
PL  - United States
TA  - Arch Intern Med
JT  - Archives of internal medicine
JID - 0372440
SB  - IM
CON - Arch Intern Med. 2011 May 23;171(10):929-35. PMID: 21357800
MH  - Adaptation, Psychological
MH  - Coronary Disease/*ethnology/mortality/*psychology/therapy
MH  - *Culture
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Prognosis
MH  - Recovery of Function
MH  - Sickness Impact Profile
MH  - Survival Rate
MH  - Time Factors
MH  - Treatment Outcome
MH  - United States
EDAT- 2011/03/02 06:00
MHDA- 2011/07/27 06:00
CRDT- 2011/03/02 06:00
PHST- 2011/03/02 06:00 [entrez]
PHST- 2011/03/02 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
AID - archinternmed.2011.40 [pii]
AID - 10.1001/archinternmed.2011.40 [doi]
PST - ppublish
SO  - Arch Intern Med. 2011 May 23;171(10):935-6. doi: 10.1001/archinternmed.2011.40.
      Epub 2011 Feb 28.


PMID- 21357699
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20150505
IS  - 1758-1117 (Electronic)
IS  - 0023-6772 (Linking)
VI  - 45
IP  - 2
DP  - 2011 Apr
TI  - A new technique for feeding dogs with a congenital cleft palate for surgical
      research.
PG  - 70-80
LID - 10.1258/la.2010.010044 [doi]
AB  - In humans, cleft palate (CP) is one of the most common malformations. Although
      surgeons use palatoplasty to close CP defects in children, its consequences for
      subsequent facial growth have prompted investigations into other novel surgical
      alternatives. The animal models of CP used to evaluate new surgical treatments
      are frequently obtained by creating surgically induced clefts in adult dogs. This
      procedure has been ethically criticized due to its severity and questionable
      value as an animal model for human CP. Dogs born with a congenital CP would be
      much better for this purpose, provided they developed CP at a sufficient rate and
      could be fed. Up until now, feeding these pups carried the risk of aspiration
      pneumonia, while impeding normal suckling and chewing, and thus compromising
      orofacial growth. We developed a technique for feeding dog pups with CP from
      birth to the time of surgery using two old Spanish pointer dog pups bearing a
      complete CP. This dog strain develops CP in 15-20% of the offspring
      spontaneously. Custom-made feeding teats and palatal prostheses adapted to the
      pups' palates were made from thermoplastic plates. This feeding technique allowed
      lactation, eating and drinking in the pups with CP, with only sporadic rhinitis. 
      To determine whether the use of this palatal prosthesis interferes with palatal
      growth, the palates of three littermate German shorthaired pointer pups without
      CP, either wearing or not wearing (controls) the prosthesis, were measured. The
      results showed that the permanent use of this prosthesis does not impede palatal 
      growth in the pups.
FAU - Martinez-Sanz, Elena
AU  - Martinez-Sanz E
AD  - Departamento de Anatomia y Embriologia Humana I, Facultad de Odontologia,
      Universidad Complutense de Madrid, Avda. Complutense, s/n 28040 Madrid, Spain.
FAU - Casado-Gomez, Inmaculada
AU  - Casado-Gomez I
FAU - Martin, Concepcion
AU  - Martin C
FAU - Lopez-Gordillo, Yamila
AU  - Lopez-Gordillo Y
FAU - Gonzalez, Pablo
AU  - Gonzalez P
FAU - Rodriguez-Bobada, Cruz
AU  - Rodriguez-Bobada C
FAU - Paradas, Irene
AU  - Paradas I
FAU - Gonzalez-Meli, Beatriz
AU  - Gonzalez-Meli B
FAU - Maldonado, Estela
AU  - Maldonado E
FAU - Maestro, Carmen
AU  - Maestro C
FAU - Prados, Juan Carlos
AU  - Prados JC
FAU - Martinez-Alvarez, Concepcion
AU  - Martinez-Alvarez C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110228
PL  - England
TA  - Lab Anim
JT  - Laboratory animals
JID - 0112725
SB  - IM
MH  - Animals
MH  - Cleft Palate/surgery/*veterinary
MH  - Disease Models, Animal
MH  - Dogs/*abnormalities
MH  - Feeding Methods/*instrumentation
MH  - Female
MH  - Humans
MH  - Male
MH  - Palatal Obturators/*veterinary
MH  - Palate/abnormalities/growth & development
EDAT- 2011/03/02 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/03/02 06:00
PHST- 2011/03/02 06:00 [entrez]
PHST- 2011/03/02 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - la.2010.010044 [pii]
AID - 10.1258/la.2010.010044 [doi]
PST - ppublish
SO  - Lab Anim. 2011 Apr;45(2):70-80. doi: 10.1258/la.2010.010044. Epub 2011 Feb 28.


PMID- 21357522
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 259
IP  - 2
DP  - 2011 May
TI  - Prostate cancer ablation with transrectal high-intensity focused ultrasound:
      assessment of tissue destruction with contrast-enhanced US.
PG  - 583-91
LID - 10.1148/radiol.11101489 [doi]
AB  - PURPOSE: To assess contrast material-enhanced ultrasonographic (US) findings seen
      after high-intensity focused ultrasound (HIFU) ablation of prostate cancer and
      correlate the US findings with post-HIFU biopsy findings. MATERIALS AND METHODS: 
      The study was ethics committee approved. Written informed consent was obtained
      from all patients. Twenty-eight patients referred for HIFU prostate cancer
      ablation underwent contrast-enhanced prostate US before treatment,
      gadolinium-enhanced magnetic resonance (MR) imaging and repeat contrast-enhanced 
      US 1-3 days after treatment, and contrast-enhanced US-guided biopsy 30-45 days
      after treatment. The contrast-enhanced US enhancement patterns of the biopsy
      sites--assigned a score of S0 for no enhancement, S1 for mild and/or patchy
      enhancement, or S2 for marked enhancement--were compared with corresponding
      biopsy findings, which were assigned a score of B0 for necrosis and/or fibrosis
      without viable prostate gland tissue, B1 for vascularized tissue without viable
      gland tissue, or B2 for viable gland tissue (benign or malignant). Then, six
      additional patients underwent contrast-enhanced prostate US 15-30 minutes and 1
      day after HIFU ablation, and the results of these two US examinations were
      compared. RESULTS: Contrast-enhanced US performed on days 1-3 and days 30-45
      after HIFU ablation depicted a large devascularized zone with peripheral
      enhancing areas that were localized anteriorly in all 28 patients, posteriorly in
      nine, laterally in five, and at the apex in 20 patients. MR findings were
      concordant. At biopsy, viable gland tissue was found at nine (6.2%) of 146 S0
      sites, 10 (34%) of 29 S1 sites, and 44 (60%) of 73 S2 sites. The odds ratios for 
      finding viable tissue (score B1 or B2) at S1 and S2 sites as opposed to S0 sites 
      were 21 (95% confidence interval [CI]: 6, 71) and 73 (95% CI: 22, 243),
      respectively (P < .0001). Contrast-enhanced US performed 15-30 minutes and 1 day 
      after treatment in the six additional patients had similar findings. CONCLUSION: 
      Contrast-enhanced US is a promising tool for distinguishing between ablated
      (devascularized) and viable (enhancing) tissue immediately after HIFU treatment.
CI  - RSNA, 2011
FAU - Rouviere, Olivier
AU  - Rouviere O
AD  - Department of Urinary and Vascular Radiology, Hopital Edouard Herriot, Hospices
      Civils de Lyon, 5 place d'Arsonval, Pavilion P Radio, Lyon F-69437, France.
      olivier.rouviere@netcourrier.com
FAU - Glas, Ludivine
AU  - Glas L
FAU - Girouin, Nicolas
AU  - Girouin N
FAU - Mege-Lechevallier, Florence
AU  - Mege-Lechevallier F
FAU - Gelet, Albert
AU  - Gelet A
FAU - Dantony, Emmanuelle
AU  - Dantony E
FAU - Rabilloud, Muriel
AU  - Rabilloud M
FAU - Chapelon, Jean-Yves
AU  - Chapelon JY
FAU - Lyonnet, Denis
AU  - Lyonnet D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110225
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 0 (Phospholipids)
RN  - 0 (contrast agent BR1)
RN  - 6HG8UB2MUY (Meglumine)
RN  - L0ND3981AG (gadoterate meglumine)
RN  - WS7LR3I1D6 (Sulfur Hexafluoride)
SB  - IM
MH  - Aged
MH  - Biopsy
MH  - Contrast Media
MH  - Humans
MH  - Logistic Models
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Meglumine
MH  - Organometallic Compounds
MH  - Phospholipids
MH  - Prostatic Neoplasms/*diagnostic imaging/pathology/*therapy
MH  - Retreatment
MH  - Sulfur Hexafluoride
MH  - Treatment Outcome
MH  - Ultrasonography, Interventional
MH  - Ultrasound, High-Intensity Focused, Transrectal/methods
EDAT- 2011/03/02 06:00
MHDA- 2011/07/27 06:00
CRDT- 2011/03/02 06:00
PHST- 2011/03/02 06:00 [entrez]
PHST- 2011/03/02 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
AID - radiol.11101489 [pii]
AID - 10.1148/radiol.11101489 [doi]
PST - ppublish
SO  - Radiology. 2011 May;259(2):583-91. doi: 10.1148/radiol.11101489. Epub 2011 Feb
      25.


PMID- 21357519
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20220311
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 259
IP  - 2
DP  - 2011 May
TI  - Sonoelastography of the plantar fascia.
PG  - 502-7
LID - 10.1148/radiol.11101665 [doi]
AB  - PURPOSE: To compare the stiffness of the plantar fascia by using sonoelastography
      in healthy subjects of different ages, as well as patients with plantar
      fasciitis. MATERIALS AND METHODS: The study protocol was approved by the Research
      Ethics Committee of the hospital, and all of the subjects gave their informed
      consent. Bilateral feet of 40 healthy subjects and 13 subjects with plantar
      fasciitis (fasciitis group) were examined by using color-coded sonoelastography. 
      Healthy subjects were divided into younger (18-50 years) and older (> 50 years)
      groups. The color scheme was red (hard), green (medium stiffness), and blue
      (soft). The color histogram was subsequently analyzed. Each pixel of the image
      was separated into red, green, and blue components (color intensity range,
      0-255). The color histogram then computed the mean intensity of each color
      component of the pixels within a standardized area. Mixed model for repeated
      measurements was used for comparison of the plantar fascia thickness and the
      intensity of the color components on sonoelastogram. RESULTS: Quantitative
      analysis of the color histogram revealed a significantly greater intensity of
      blue in older healthy subjects than in younger (94.5 +/- 5.6 [+/- standard
      deviation] vs 90.0 +/- 4.6, P = .002) subjects. The intensity of red and green
      was the same between younger and older healthy subjects (P = .68 and 0.12). The
      intensity of red was significantly greater in older healthy subjects than in the 
      fasciitis group (147.8 +/- 10.3 vs 133.7 +/- 13.4, P < .001). The intensity of
      green and blue was the same between older healthy subjects and those in the
      fasciitis group (P = .33 and .71). CONCLUSION: Sonoelastography revealed that the
      plantar fascia softens with age and in subjects with plantar fasciitis.
CI  - RSNA, 2011
FAU - Wu, Chueh-Hung
AU  - Wu CH
AD  - Department of Physical Medicine & Rehabilitation, National Taiwan University
      Hospital Yun-Lin Branch, Yunlin, Taiwan, ROC.
FAU - Chang, Ke-Vin
AU  - Chang KV
FAU - Mio, Sun
AU  - Mio S
FAU - Chen, Wen-Shiang
AU  - Chen WS
FAU - Wang, Tyng-Guey
AU  - Wang TG
LA  - eng
PT  - Journal Article
DEP - 20110225
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
CIN - Radiology. 2011 Dec;261(3):995-6. PMID: 22096000
MH  - Adolescent
MH  - Adult
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - Color
MH  - Elasticity Imaging Techniques/*methods
MH  - Fascia/*diagnostic imaging
MH  - Fasciitis, Plantar/*diagnostic imaging
MH  - Female
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Male
MH  - Middle Aged
MH  - Reproducibility of Results
EDAT- 2011/03/02 06:00
MHDA- 2011/07/27 06:00
CRDT- 2011/03/02 06:00
PHST- 2011/03/02 06:00 [entrez]
PHST- 2011/03/02 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
AID - radiol.11101665 [pii]
AID - 10.1148/radiol.11101665 [doi]
PST - ppublish
SO  - Radiology. 2011 May;259(2):502-7. doi: 10.1148/radiol.11101665. Epub 2011 Feb 25.


PMID- 21357208
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20110421
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 5
DP  - 2011 May
TI  - Advance directives and older people: ethical challenges in the promotion of
      advance directives in New Zealand.
PG  - 285-9
LID - 10.1136/jme.2010.039701 [doi]
AB  - In New Zealand an advance directive can be either an oral statement or a written 
      document. Such directives give individuals the opportunity to make choices about 
      future medical treatment in the event they are cognitively impaired or otherwise 
      unable to make their preferences known. All consumers of health care have the
      right to make an advance directive in accordance with the common law. When we
      consider New Zealand's rapidly ageing population, the fact that more people now
      live with and die of chronic rather than acute conditions, the importance given
      to respecting autonomous decision-making, increasing numbers of individuals who
      require long-term residential care, and financial pressures in the allocation of 
      medical resources, there would seem to be a number of compelling reasons to
      encourage individuals to write or verbalize an advance directive. Indeed the
      promotion of advance directives is encouraged. However, caution should be
      exercised in promoting advance directives to older people, especially in light of
      several factors: ageist attitudes and stereotypes towards them, challenges in the
      primary healthcare setting, and the way in which advance directives are currently
      focused and formulated. This paper considers some of the specific challenges that
      need to be addressed if the promotion of advance directives are to improve
      outcomes of patient treatment and care near the end of life.
FAU - Malpas, Phillipa J
AU  - Malpas PJ
AD  - Department of Psychological Medicine, Faculty of Medical and Health Sciences,
      University of Auckland, Private Bag 92019, Auckland, New Zealand.
      p.malpas@auckland.ac.nz
LA  - eng
PT  - Journal Article
DEP - 20110227
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Advance Directives/*legislation & jurisprudence/psychology
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Attitude to Death
MH  - Choice Behavior
MH  - *Decision Making
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Living Wills/*legislation & jurisprudence/psychology
MH  - Male
MH  - New Zealand
MH  - Patient Rights/legislation & jurisprudence
MH  - Primary Health Care
MH  - Quality of Life
MH  - Right to Die/*legislation & jurisprudence
EDAT- 2011/03/02 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/03/02 06:00
PHST- 2011/03/02 06:00 [entrez]
PHST- 2011/03/02 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - jme.2010.039701 [pii]
AID - 10.1136/jme.2010.039701 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 May;37(5):285-9. doi: 10.1136/jme.2010.039701. Epub 2011 Feb
      27.


PMID- 21356496
OWN - NLM
STAT- MEDLINE
DCOM- 20110412
LR  - 20110301
IS  - 1879-1190 (Electronic)
IS  - 1072-7515 (Linking)
VI  - 212
IP  - 3
DP  - 2011 Mar
TI  - Ethicon prolene hernia system is not a plug.
PG  - 424; author reply 424-5
LID - 10.1016/j.jamcollsurg.2010.11.010 [doi]
FAU - Kent, Raleigh
AU  - Kent R
LA  - eng
PT  - Comment
PT  - Letter
PL  - United States
TA  - J Am Coll Surg
JT  - Journal of the American College of Surgeons
JID - 9431305
RN  - 0 (Biocompatible Materials)
RN  - 0 (Polypropylenes)
SB  - IM
CON - J Am Coll Surg. 2010 Oct;211(4):481-4. PMID: 20822742
MH  - Biocompatible Materials
MH  - Hernia, Inguinal/*surgery
MH  - Humans
MH  - *Polypropylenes
MH  - *Surgical Mesh
EDAT- 2011/03/02 06:00
MHDA- 2011/04/13 06:00
CRDT- 2011/03/02 06:00
PHST- 2010/11/08 00:00 [received]
PHST- 2010/11/23 00:00 [accepted]
PHST- 2011/03/02 06:00 [entrez]
PHST- 2011/03/02 06:00 [pubmed]
PHST- 2011/04/13 06:00 [medline]
AID - S1072-7515(10)01231-7 [pii]
AID - 10.1016/j.jamcollsurg.2010.11.010 [doi]
PST - ppublish
SO  - J Am Coll Surg. 2011 Mar;212(3):424; author reply 424-5. doi:
      10.1016/j.jamcollsurg.2010.11.010.


PMID- 21356097
OWN - NLM
STAT- MEDLINE
DCOM- 20110720
LR  - 20220316
IS  - 1472-6947 (Electronic)
IS  - 1472-6947 (Linking)
VI  - 11
DP  - 2011 Feb 28
TI  - The role of the user within the medical device design and development process:
      medical device manufacturers' perspectives.
PG  - 15
LID - 10.1186/1472-6947-11-15 [doi]
AB  - BACKGROUND: Academic literature and international standards bodies suggest that
      user involvement, via the incorporation of human factors engineering methods
      within the medical device design and development (MDDD) process, offer many
      benefits that enable the development of safer and more usable medical devices
      that are better suited to users' needs. However, little research has been carried
      out to explore medical device manufacturers' beliefs and attitudes towards user
      involvement within this process, or indeed what value they believe can be added
      by doing so. METHODS: In-depth interviews with representatives from 11 medical
      device manufacturers are carried out. We ask them to specify who they believe the
      intended users of the device to be, who they consult to inform the MDDD process, 
      what role they believe the user plays within this process, and what value (if
      any) they believe users add. Thematic analysis is used to analyse the fully
      transcribed interview data, to gain insight into medical device manufacturers'
      beliefs and attitudes towards user involvement within the MDDD process. RESULTS: 
      A number of high-level themes emerged, relating who the user is perceived to be, 
      the methods used, the perceived value and barriers to user involvement, and the
      nature of user contributions. The findings reveal that despite standards agencies
      and academic literature offering strong support for the employment formal
      methods, manufacturers are still hesitant due to a range of factors including:
      perceived barriers to obtaining ethical approval; the speed at which such
      activity may be carried out; the belief that there is no need given the
      'all-knowing' nature of senior health care staff and clinical champions; a belief
      that effective results are achievable by consulting a minimal number of
      champions. Furthermore, less senior health care practitioners and patients were
      rarely seen as being able to provide valuable input into the process.
      CONCLUSIONS: Medical device manufacturers often do not see the benefit of
      employing formal human factors engineering methods within the MDDD process.
      Research is required to better understand the day-to-day requirements of
      manufacturers within this sector. The development of new or adapted methods may
      be required if user involvement is to be fully realised.
FAU - Money, Arthur G
AU  - Money AG
AD  - Department of Computer Science and Technology, University of Bedfordshire, Park
      Square, Luton, UK. arthur.money@brunel.ac.uk
FAU - Barnett, Julie
AU  - Barnett J
FAU - Kuljis, Jasna
AU  - Kuljis J
FAU - Craven, Michael P
AU  - Craven MP
FAU - Martin, Jennifer L
AU  - Martin JL
FAU - Young, Terry
AU  - Young T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110228
PL  - England
TA  - BMC Med Inform Decis Mak
JT  - BMC medical informatics and decision making
JID - 101088682
SB  - IM
MH  - *Community Participation
MH  - *Equipment Design
MH  - Humans
MH  - Safety
MH  - Technology Assessment, Biomedical/methods
PMC - PMC3058010
EDAT- 2011/03/02 06:00
MHDA- 2011/07/21 06:00
CRDT- 2011/03/02 06:00
PHST- 2010/10/28 00:00 [received]
PHST- 2011/02/28 00:00 [accepted]
PHST- 2011/03/02 06:00 [entrez]
PHST- 2011/03/02 06:00 [pubmed]
PHST- 2011/07/21 06:00 [medline]
AID - 1472-6947-11-15 [pii]
AID - 10.1186/1472-6947-11-15 [doi]
PST - epublish
SO  - BMC Med Inform Decis Mak. 2011 Feb 28;11:15. doi: 10.1186/1472-6947-11-15.


PMID- 21355765
OWN - NLM
STAT- MEDLINE
DCOM- 20110830
LR  - 20211020
IS  - 1360-046X (Electronic)
IS  - 0268-8697 (Linking)
VI  - 25
IP  - 3
DP  - 2011 Jun
TI  - Obtaining regulatory approval for multicentre randomised controlled trials:
      experiences in the STICH II trial.
PG  - 352-6
LID - 10.3109/02688697.2010.551675 [doi]
AB  - BACKGROUND AND PURPOSE: Centres wishing to participate in international
      multicentre randomised controlled surgical trials such as STICH II (Surgical
      Trial in Lobar Intracerebral Haemorrhage) have to go through a number of
      regulatory hurdles. These depend on the nature of the study. In surgical studies,
      there is a need to obtain ethical approval and individual hospital approval
      including fully executing contracts between the host organisation and each
      institution. Firsthand experience has been gained in STICH II by guiding over 80 
      hospitals through this process in over 20 different countries worldwide. METHODS:
      This article examines the administrative challenges of setting up the STICH II
      trial which include the time that it has taken for each hospital to obtain
      ethical approval, sign the study agreement and become a fully registered site.
      The aim of this article is to inform potential triallists planning multinational 
      surgical trials about the potential delays and difficulties that may be
      encountered in the hope that it will encourage the medical research community to 
      simplify administrative systems. We also hope to influence trial funders to build
      in 'start up periods' for new studies so that they can get up and running in a
      realistic time frame. The difficulties which were faced will be highlighted so
      that the organisers of other randomised controlled surgical trials can be aware
      of these delays. CONCLUSION: From the experiences in this trial, it can be
      concluded that delays will be experienced in obtaining ethical approval and in
      agreeing on site contracts.
FAU - Kenyon, Gillian M
AU  - Kenyon GM
AD  - Neurosurgical Trials Unit, Newcastle University, Newcastle upon Tyne, NE2 4AE,
      UK. gilliankenyon1986@hotmail.co.uk
FAU - Mendelow, Alexander David
AU  - Mendelow AD
FAU - Gregson, Barbara A
AU  - Gregson BA
FAU - Rowan, Elise
AU  - Rowan E
LA  - eng
GR  - G0501444/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Review
DEP - 20110228
PL  - England
TA  - Br J Neurosurg
JT  - British journal of neurosurgery
JID - 8800054
SB  - IM
MH  - Cerebral Hemorrhage/*surgery
MH  - Ethics Committees/*organization & administration
MH  - Guidelines as Topic
MH  - Humans
MH  - Multicenter Studies as Topic/*ethics
MH  - Prospective Studies
MH  - Randomized Controlled Trials as Topic/*ethics
EDAT- 2011/03/02 06:00
MHDA- 2011/08/31 06:00
CRDT- 2011/03/02 06:00
PHST- 2011/03/02 06:00 [entrez]
PHST- 2011/03/02 06:00 [pubmed]
PHST- 2011/08/31 06:00 [medline]
AID - 10.3109/02688697.2010.551675 [doi]
PST - ppublish
SO  - Br J Neurosurg. 2011 Jun;25(3):352-6. doi: 10.3109/02688697.2010.551675. Epub
      2011 Feb 28.


PMID- 21355688
OWN - NLM
STAT- MEDLINE
DCOM- 20120109
LR  - 20110822
IS  - 1466-187X (Electronic)
IS  - 0142-159X (Linking)
VI  - 33
IP  - 9
DP  - 2011
TI  - How we implemented an integrated professionalism curriculum to 2nd year medical
      students at the National University of Ireland Galway Medical School, with
      examples from students' final output.
PG  - 710-2
LID - 10.3109/0142159X.2010.546908 [doi]
AB  - Since the introduction of professionalism in medical curricula worldwide, little 
      evidence has been published to exemplify good educational practice. The Medical
      school at the National University of Ireland Galway teaches professionalism in an
      interdisciplinary manner, integrating the learning objectives of health
      informatics, understanding health & illness in society, medical law and ethics.
      Students work in small groups on clinical cases. Enquiry-based learning is used
      as the teaching method following a few introductory lectures on specific
      objectives. Students present their work in the format of a scientific essay. The 
      latter is assessed by a board of reviewers. The purpose of this article is to
      demonstrate evidence of excellent professional output and illustrate the benefits
      to a fully integrated professionalism curriculum.
FAU - McNair, Antonia
AU  - McNair A
AD  - National University of Ireland Galway, Ireland.
FAU - Moran, Conor
AU  - Moran C
FAU - McGrath, Erinn
AU  - McGrath E
FAU - Naqvi, Syed
AU  - Naqvi S
FAU - Connolly, Claire
AU  - Connolly C
FAU - McKenna, Verna
AU  - McKenna V
FAU - Kropmans, Thomas
AU  - Kropmans T
LA  - eng
PT  - Journal Article
DEP - 20110228
PL  - England
TA  - Med Teach
JT  - Medical teacher
JID - 7909593
SB  - IM
MH  - *Curriculum
MH  - Education, Medical, Undergraduate
MH  - Humans
MH  - Ireland
MH  - Organizational Case Studies
MH  - Program Development/*methods
MH  - *Program Evaluation
MH  - *Schools, Medical
EDAT- 2011/03/02 06:00
MHDA- 2012/01/10 06:00
CRDT- 2011/03/02 06:00
PHST- 2011/03/02 06:00 [entrez]
PHST- 2011/03/02 06:00 [pubmed]
PHST- 2012/01/10 06:00 [medline]
AID - 10.3109/0142159X.2010.546908 [doi]
PST - ppublish
SO  - Med Teach. 2011;33(9):710-2. doi: 10.3109/0142159X.2010.546908. Epub 2011 Feb 28.


PMID- 21353977
OWN - NLM
STAT- MEDLINE
DCOM- 20110413
LR  - 20131121
IS  - 1878-4321 (Electronic)
IS  - 1049-3867 (Linking)
VI  - 21
IP  - 2
DP  - 2011 Mar-Apr
TI  - Do religious restrictions influence ectopic pregnancy management? A national
      qualitative study.
PG  - 104-9
LID - 10.1016/j.whi.2010.11.006 [doi]
AB  - INTRODUCTION: In the United States, ectopic pregnancies are relatively common and
      associated with significant maternal morbidity and mortality. The Ethical and
      Religious Directives for Catholic Health Care Services (the Directives) govern
      the provision of care in Catholic-affiliated hospitals and prohibit the provision
      of abortion in almost all circumstances. Although ectopic pregnancies are not
      viable, some Catholic ethicists have argued that the Directives preclude
      physicians at Catholic hospitals from managing tubal pregnancies with methods and
      procedures that involve "direct" action against the embryo. METHODS: We undertook
      this qualitative study to explore the relationship between the Directives,
      hospital policies regarding ectopic pregnancy management, and clinical practices.
      We recruited participants at non-Catholic, longstanding Catholic, and recently
      merged facilities and conducted focused interviews with 24 physicians at 16
      hospitals in 10 states. FINDINGS: Participants from three Catholic facilities
      reported that medical therapy with methotrexate was not offered because of their 
      hospitals' religious affiliation. The lack of methotrexate resulted in changes in
      counseling and practice patterns, including managing ectopic pregnancies
      expectantly, providing the medication surreptitiously, and transferring patients 
      to other facilities. Further, several physicians reported that, before initiating
      treatment, they were required to document nonviability through what they
      perceived as unnecessary paperwork, tests, and imaging studies. CONCLUSION: Our
      findings suggest that some interpretations of the Directives are precluding
      physicians from providing women with ectopic pregnancies with information about
      and access to a full range of treatment options and are resulting in practices
      that delay care and may expose women to unnecessary risks.
CI  - Copyright (c) 2011 Jacobs Institute of Women's Health. Published by Elsevier Inc.
      All rights reserved.
FAU - Foster, Angel M
AU  - Foster AM
AD  - Ibis Reproductive Health, 17 Dunster Street, Cambridge, MA 02138, USA.
      afoster@ibisreproductivehealth.org
FAU - Dennis, Amanda
AU  - Dennis A
FAU - Smith, Fiona
AU  - Smith F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Womens Health Issues
JT  - Women's health issues : official publication of the Jacobs Institute of Women's
      Health
JID - 9101000
RN  - 0 (Abortifacient Agents, Nonsteroidal)
RN  - YL5FZ2Y5U1 (Methotrexate)
SB  - IM
MH  - Abortifacient Agents, Nonsteroidal/therapeutic use
MH  - *Catholicism
MH  - *Ethics, Institutional
MH  - Female
MH  - Hospitals, Religious/*organization & administration/standards
MH  - Humans
MH  - Methotrexate/therapeutic use
MH  - Organizational Culture
MH  - Organizational Policy
MH  - Physicians
MH  - Pregnancy
MH  - Pregnancy, Tubal/*therapy
MH  - Qualitative Research
MH  - *Religion and Medicine
MH  - United States
EDAT- 2011/03/01 06:00
MHDA- 2011/04/14 06:00
CRDT- 2011/03/01 06:00
PHST- 2010/07/21 00:00 [received]
PHST- 2010/11/15 00:00 [revised]
PHST- 2010/11/16 00:00 [accepted]
PHST- 2011/03/01 06:00 [entrez]
PHST- 2011/03/01 06:00 [pubmed]
PHST- 2011/04/14 06:00 [medline]
AID - S1049-3867(10)00155-6 [pii]
AID - 10.1016/j.whi.2010.11.006 [doi]
PST - ppublish
SO  - Womens Health Issues. 2011 Mar-Apr;21(2):104-9. doi: 10.1016/j.whi.2010.11.006.


PMID- 31051796
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1876-7982 (Electronic)
IS  - 1876-7982 (Linking)
VI  - 42
IP  - 1
DP  - 2011 Mar
TI  - An Investigation into the Variability of Breast Tangent Setups Using the Portal
      Imaging Process.
PG  - 32-36
LID - 10.1016/j.jmir.2010.11.002 [doi]
AB  - This study set out to examine the imaging schedule for a specific group of
      patients, that is, those receiving the two-field tangent technique for breast
      cancer treatment at our centre. This group makes up a large percentage of our
      workload. The departmental policy on imaging for breast tangent patients at the
      time the study was conducted stated that one image be taken on either the medial 
      or lateral tangent field on the first day of treatment. The majority of images
      were taken pre-treatment (the current policy has been updated to specify
      pre-treatment images) and if a setup discrepancy was noted adjustments were made 
      and another image taken. The study consisted of eighteen patients who attended
      the centre for treatment and who were prescribed a tangent technique. Eligible
      patients were identified from the appointment scheduling system. Consent to
      participate was given at the time of the patients planning appointment. The study
      was reviewed by the Research Ethics Board at our affiliated hospital and was
      supported by the breast site group at the centre. There was no exclusion
      criterion. 133 images were taken during the course of this study. The lung volume
      was measured at three specific points with the measuring tools available from the
      software programme. The results demonstrated that for the majority of patients
      (94%) the setup variability does not warrant a change to the current imaging
      protocol. Data from one patient (6%), however, suggested that for some patients
      there may be a need for a more comprehensive imaging schedule. The variability of
      setup for these patients was unpredictable. This group of patients would require 
      further investigation and discussion within the site group at our centre.
CI  - Crown Copyright (c) 2011. Published by Elsevier Inc. All rights reserved.
FAU - Turner, Angela S
AU  - Turner AS
AD  - Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario,
      Canada.
FAU - Goodbrand, Anne
AU  - Goodbrand A
AD  - Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario,
      Canada.
FAU - Di Prospero, Lisa
AU  - Di Prospero L
AD  - Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario,
      Canada.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Med Imaging Radiat Sci
JT  - Journal of medical imaging and radiation sciences
JID - 101469694
EDAT- 2011/03/01 00:00
MHDA- 2011/03/01 00:01
CRDT- 2019/05/05 06:00
PHST- 2010/08/24 00:00 [received]
PHST- 2010/11/03 00:00 [revised]
PHST- 2010/11/08 00:00 [accepted]
PHST- 2019/05/05 06:00 [entrez]
PHST- 2011/03/01 00:00 [pubmed]
PHST- 2011/03/01 00:01 [medline]
AID - S1939-8654(10)00079-2 [pii]
AID - 10.1016/j.jmir.2010.11.002 [doi]
PST - ppublish
SO  - J Med Imaging Radiat Sci. 2011 Mar;42(1):32-36. doi: 10.1016/j.jmir.2010.11.002.


PMID- 28683607
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1833-3575 (Electronic)
IS  - 1833-3583 (Linking)
VI  - 40
IP  - 1
DP  - 2011 Mar
TI  - Emerging Technologies: Web 2.0.
PG  - 33-35
LID - 10.1177/183335831104000106 [doi]
AB  - Web 2.0 has brought a change to how we communicate and disseminate information
      with the use of Twitter, Facebook, YouTube, instant messaging and blogging. This 
      technology is beginning to be used in the health field for public awareness
      campaigns, emergency health alerts, medical education and remote healthcare
      services. Australian Health Information Managers will be called upon to reconcile
      their organisations' policies and procedures regarding the use of Web 2.0
      technologies within the existing legal framework of privacy, confidentiality and 
      consent. This article explores various applications of Web 2.0, their benefits
      and some of their potential legal and ethical implications when implemented in
      Australia.
FAU - Holt, Claire
AU  - Holt C
AD  - Claire Holt BHIM Honours Candidate, Health Information Management Department,
      School of Public Health, La Trobe University, Bundoora VIC 3086, AUSTRALIA,
      Previously, Nursing Education Administration Co-ordinator, Royal Melbourne
      Hospital.
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Health Inf Manag
JT  - Health information management : journal of the Health Information Management
      Association of Australia
JID - 9438200
OTO - NOTNLM
OT  - Confidentiality
OT  - Information Dissemination
OT  - Information Sharing
OT  - Internet
OT  - Social Networks
EDAT- 2011/03/01 00:00
MHDA- 2011/03/01 00:01
CRDT- 2017/07/08 06:00
PHST- 2017/07/08 06:00 [entrez]
PHST- 2011/03/01 00:00 [pubmed]
PHST- 2011/03/01 00:01 [medline]
AID - 10.1177/183335831104000106 [doi]
PST - ppublish
SO  - Health Inf Manag. 2011 Mar;40(1):33-35. doi: 10.1177/183335831104000106.


PMID- 26086980
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20161230
IS  - 1552-8448 (Electronic)
IS  - 1077-8012 (Linking)
VI  - 17
IP  - 3
DP  - 2011 Mar
TI  - The Need for Experimental Methodology in Intimate Partner Violence: Finding
      Programs That Effectively Prevent IPV.
PG  - 340-58
LID - 10.1177/1077801211398620 [doi]
AB  - The lack of rigorous evaluations of intimate partner violence (IPV) programs has 
      severely limited our knowledge about what works. However, IPV programs can be
      rigorously evaluated through randomized controlled trials (RCTs) conducted
      ethically and safely. This article provides an example of how a RCT to test an
      IPV preventive intervention-the Enhanced Nurse Family Partnership Study
      (ENFPS)-was successfully implemented by a partnership of researchers and
      practitioners. The article concludes with some recommendations, arrived at by the
      researchers and practitioners on the ENFPS team, for achieving a successful
      collaboration thought to be essential in executing a field experiment.
CI  - (c) The Author(s) 2011.
FAU - Feder, Lynette
AU  - Feder L
AD  - Portland State University, LFeder@pdx.edu.
FAU - Holditch Niolon, Phyllis
AU  - Holditch Niolon P
AD  - Centers for Disease Control and Prevention, Division of Violence Prevention.
FAU - Campbell, Jacquelyn
AU  - Campbell J
AD  - Johns Hopkins University School of Nursing.
FAU - Wallinder, Jan
AU  - Wallinder J
AD  - Multnomah County Health Department.
FAU - Nelson, Robin
AU  - Nelson R
AD  - Multnomah County Health Department.
FAU - Larrouy, Hattie
AU  - Larrouy H
AD  - Multnomah County Health Department.
LA  - eng
GR  - HHS-1-U49-CE000516/CE/NCIPC CDC HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Violence Against Women
JT  - Violence against women
JID - 9506308
SB  - IM
MH  - *Cooperative Behavior
MH  - Domestic Violence/*prevention & control
MH  - Female
MH  - Humans
MH  - Intimate Partner Violence/*prevention & control
MH  - Male
MH  - Nurses
MH  - *Program Evaluation/methods
MH  - Rape/*prevention & control
MH  - Research Design
MH  - Research Personnel
MH  - Sexual Partners
OTO - NOTNLM
OT  - experimental research
OT  - intimate partner violence
OT  - prevention
EDAT- 2011/03/01 00:00
MHDA- 2016/12/15 06:00
CRDT- 2015/06/19 06:00
PHST- 2015/06/19 06:00 [entrez]
PHST- 2011/03/01 00:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - 17/3/340 [pii]
AID - 10.1177/1077801211398620 [doi]
PST - ppublish
SO  - Violence Against Women. 2011 Mar;17(3):340-58. doi: 10.1177/1077801211398620.


PMID- 25299558
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151026
LR  - 20141010
IS  - 0103-507X (Print)
IS  - 0103-507X (Linking)
VI  - 23
IP  - 1
DP  - 2011 Mar
TI  - Dilemmas and difficulties involving end-of-life decisions and palliative care in 
      children.
PG  - 78-86
LID - S0103-507X2011000100013 [pii]
AB  - This review discusses the main dilemmas and difficulties related to end-of-life
      decision's in children with terminal and irreversible diseases and propose a
      rational sequence for delivering palliative care to this patients' group. The
      Medline and Lilacs databases were searched using the terms 'end of life',
      'palliative care', 'death' and 'terminal disease' for articles published in
      recent years. The most relevant articles and those enrolling pediatric patients
      were selected and compared to previous authors' studies in this field. The
      current Brazilian Medical Ethics Code (2010) was analyzed regarding end-oflife
      practices and palliative care for terminal patients. Lack of knowledge,
      insufficient specific training, and legal concerns are the main reasons why
      end-of-life decisions in terminal children are based on medical opinion with
      scarce family participation. The current Brazilian Medical Ethics Code (2010)
      fully supports end-of-life decisions made consensually with active family
      participation. Honest dialogue with the family regarding diagnostic, prognostic, 
      therapeutic and palliative care measures should be established gradually to
      identify the best strategy to meet the child's end-of-life needs. Treatment
      focused on the child's welfare combined with the family's participation is the
      basis for successful palliative care of children with terminal diseases.
FAU - Piva, Jefferson Pedro
AU  - Piva JP
AD  - Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre,
      RS, Brasil.
FAU - Garcia, Pedro Celiny Ramos
AU  - Garcia PC
AD  - Faculdade de Medicina, Universidade Catolica do Rio Grande do Sul, Porto Alegre, 
      RS.
FAU - Lago, Patricia Miranda
AU  - Lago PM
AD  - Hospital de Clinicas, Porto Alegre.
LA  - eng
LA  - por
PT  - Journal Article
TT  - Dilemas e dificuldades envolvendo decisoes de final de vida e oferta de cuidados 
      paliativos em pediatria.
PL  - Brazil
TA  - Rev Bras Ter Intensiva
JT  - Revista Brasileira de terapia intensiva
JID - 9506692
EDAT- 2011/03/01 00:00
MHDA- 2011/03/01 00:01
CRDT- 2014/10/10 06:00
PHST- 2010/12/03 00:00 [received]
PHST- 2011/01/18 00:00 [accepted]
PHST- 2014/10/10 06:00 [entrez]
PHST- 2011/03/01 00:00 [pubmed]
PHST- 2011/03/01 00:01 [medline]
AID - S0103-507X2011000100013 [pii]
PST - ppublish
SO  - Rev Bras Ter Intensiva. 2011 Mar;23(1):78-86.


PMID- 24850201
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140523
LR  - 20160511
IS  - 1947-5535 (Print)
IS  - 1947-5543 (Linking)
VI  - 9
IP  - 1
DP  - 2011 Mar
TI  - Setting up a Prospective Thyroid Biobank for Translational Research: Practical
      Approach of a Single Institution (2004-2009, Pasteur Hospital, Nice, France).
PG  - 9-19
LID - 10.1089/bio.2010.0024 [doi]
AB  - In the last few years, conditions for setting up a human biobank in France have
      been upgraded by taking into account (1) the new laws and regulations that
      integrate the ethical and societal dimension of biobanking and delineate the
      risks for patients associated with the procurement of human cells and tissues,
      (2) the increasing request by scientists for human samples with proven biological
      quality and sophisticated sets of annotations, including information produced
      through the evergrowing use of molecular biology in pathology, and (3)
      establishment of procedures concerning the safety of the personnel working with
      biological products. For this purpose, health authorities and national research
      institutes in France have provided significant support for the set up of
      biobanks. The present work was conducted to describe how we set up a biobank
      targeting diseases of a specific organ (thyroid gland), with the aim of rapidly
      developing translational research projects. The prospective experience of a
      single institution (Pasteur Hospital, Nice, France) over a 6-year period
      (2004-2009) is presented from the practical point of view of a surgical pathology
      laboratory. We describe different procedures required to obtain high-quality
      thyroid biological resources and clinical annotations. The procedures were
      established for the management of biological products obtained from 1454 patients
      who underwent thyroid surgery. The preanalytical steps leading to the storage of 
      frozen specimens were carried out in parallel with diagnostic procedures. As the 
      number of international networks for research programs using biological products 
      is steadily increasing, it is crucial to harmonize the procedures used by
      biobanks. In this regard, the described thyroid biobank has been set up using
      criteria established by the French National Cancer Institute (Institut National
      du Cancer) to guarantee the quality of different collections stored in biobanks.
FAU - Lassalle, Sandra
AU  - Lassalle S
AD  - 1 Biobank Unit, Pasteur Hospital , Nice, France .
FAU - Hofman, Veronique
AU  - Hofman V
FAU - Ilie, Marius
AU  - Ilie M
FAU - Butori, Catherine
AU  - Butori C
FAU - Bonnetaud, Christelle
AU  - Bonnetaud C
FAU - Gaziello, Marie Clotilde
AU  - Gaziello MC
FAU - Selva, Eric
AU  - Selva E
FAU - Gavric-Tanga, Virginie
AU  - Gavric-Tanga V
FAU - Guevara, Nicolas
AU  - Guevara N
FAU - Castillo, Laurent
AU  - Castillo L
FAU - Santini, Jose
AU  - Santini J
FAU - Chabannon, Christian
AU  - Chabannon C
FAU - Hofman, Paul
AU  - Hofman P
LA  - eng
PT  - Journal Article
DEP - 20110322
PL  - United States
TA  - Biopreserv Biobank
JT  - Biopreservation and biobanking
JID - 101507284
EDAT- 2011/03/01 00:00
MHDA- 2011/03/01 00:01
CRDT- 2014/05/23 06:00
PHST- 2014/05/23 06:00 [entrez]
PHST- 2011/03/01 00:00 [pubmed]
PHST- 2011/03/01 00:01 [medline]
AID - 10.1089/bio.2010.0024 [doi]
PST - ppublish
SO  - Biopreserv Biobank. 2011 Mar;9(1):9-19. doi: 10.1089/bio.2010.0024. Epub 2011 Mar
      22.


PMID- 24038045
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130917
LR  - 20160511
IS  - 1876-3413 (Print)
IS  - 1876-3405 (Linking)
VI  - 3
IP  - 1
DP  - 2011 Mar
TI  - Sharing experiences and dilemmas of conducting focus group discussions on HIV and
      tuberculosis in resource-poor settings.
PG  - 7-14
LID - 10.1016/j.inhe.2010.09.006 [doi]
AB  - Focus group discussions (FGD) are gaining in popularity in research on HIV and
      tuberculosis (TB) internationally as researchers seek to understand the
      experiences, needs and perspectives of people living with TB and/or HIV as well
      as their carers within the community and health sector. Conducting FGDs in
      resource-poor settings with vulnerable participants who are living with diseases 
      that are frequently stigmatised poses multiple challenges. Our approach in this
      discussion paper is to follow the research cycle to present the practical
      experience of research teams using FGDs in TB and HIV in resource-poor contexts
      in Africa and Asia in order to contribute to effective practice. The approach
      highlights dilemmas and shares effective practice for negotiating initial
      discussions with different communities, constructing sampling frames and samples,
      choosing a facilitator, encouraging discussion, ethics, translation, pitfalls and
      dissemination. We demonstrate the techniques and adaptations needed to ensure
      that FGDs provide rich, high-quality and policy-relevant data on the voices and
      perspectives of people living with HIV and TB, community groups and health
      workers within the challenges of resource-poor settings. In applying theory to
      develop good practice in FGDs across the research cycle, a critical and reflexive
      approach is needed.
FAU - Theobald, Sally
AU  - Theobald S
AD  - Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.
FAU - Nyirenda, Lot
AU  - Nyirenda L
FAU - Tulloch, Olivia
AU  - Tulloch O
FAU - Makwiza, Ireen
AU  - Makwiza I
FAU - Soonthorndhada, Amara
AU  - Soonthorndhada A
FAU - Tolhurst, Rachel
AU  - Tolhurst R
FAU - Bongololo, Grace
AU  - Bongololo G
FAU - Sanou, Armande
AU  - Sanou A
FAU - Katjire, Marjorie
AU  - Katjire M
FAU - Kilonzo, Nduku
AU  - Kilonzo N
FAU - Yan, Fei
AU  - Yan F
FAU - Al-Aghbari, Nasher
AU  - Al-Aghbari N
FAU - Al-Sonboli, Najla
AU  - Al-Sonboli N
FAU - Cuevas, Rachel Anderson de
AU  - Cuevas RA
FAU - Fergusson, Pamela
AU  - Fergusson P
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int Health
JT  - International health
JID - 101517095
EDAT- 2011/03/01 00:00
MHDA- 2011/03/01 00:01
CRDT- 2013/09/17 06:00
PHST- 2013/09/17 06:00 [entrez]
PHST- 2011/03/01 00:00 [pubmed]
PHST- 2011/03/01 00:01 [medline]
AID - j.inhe.2010.09.006 [pii]
AID - 10.1016/j.inhe.2010.09.006 [doi]
PST - ppublish
SO  - Int Health. 2011 Mar;3(1):7-14. doi: 10.1016/j.inhe.2010.09.006.


PMID- 23050908
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121210
LR  - 20160519
IS  - 1876-2026 (Electronic)
IS  - 1876-2018 (Linking)
VI  - 4
IP  - 1
DP  - 2011 Mar
TI  - Pharmaceutical industry and the market: The case of Prozac and other
      antidepressants.
PG  - 14-8
LID - 10.1016/j.ajp.2011.01.002 [doi]
AB  - OBJECTIVE: This article attempts to critically evaluate the role of the
      pharmaceutical industry in health care from the theoretical standpoint of
      'medical-industrial complex'. METHODS: The historical context of the expansion of
      the pharmaceutical industry is summarized followed by a critical evaluation of
      the methods of studying effectiveness of pharmaceutical agents and the aspects
      involved in reporting, publication and marketing. Further issues are elaborated
      with a case study of the antidepressants. RESULTS: The establishment of
      pharmaceutical industry is premised on various ethical principles and moral norms
      yet such guiding values are forsaken resulting in a contradictory stance where
      human life and suffering are devalued rather than saved and ameliorated in a bid 
      to maximize profits. CONCLUSION: The conventional response of more stringent
      regulation and the broader reason of economic model of unequal power need to be
      reevaluated.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Das, Anindya
AU  - Das A
AD  - Centre for Social Medicine and Community Health, Jawaharlal Nehru University, New
      Delhi, PIN 110067, India.
LA  - eng
PT  - Journal Article
DEP - 20110217
PL  - Netherlands
TA  - Asian J Psychiatr
JT  - Asian journal of psychiatry
JID - 101517820
EDAT- 2011/03/01 00:00
MHDA- 2011/03/01 00:01
CRDT- 2012/10/12 06:00
PHST- 2009/02/08 00:00 [received]
PHST- 2010/05/29 00:00 [revised]
PHST- 2011/01/18 00:00 [accepted]
PHST- 2012/10/12 06:00 [entrez]
PHST- 2011/03/01 00:00 [pubmed]
PHST- 2011/03/01 00:01 [medline]
AID - S1876-2018(11)00003-7 [pii]
AID - 10.1016/j.ajp.2011.01.002 [doi]
PST - ppublish
SO  - Asian J Psychiatr. 2011 Mar;4(1):14-8. doi: 10.1016/j.ajp.2011.01.002. Epub 2011 
      Feb 17.


PMID- 23008980
OWN - NLM
STAT- MEDLINE
DCOM- 20121018
LR  - 20120926
IS  - 1015-7867 (Print)
IS  - 1015-7867 (Linking)
VI  - 17
IP  - 1
DP  - 2011 Mar
TI  - Left-sided congenital abdominal wall defect and intestinal malformation--a rare
      case.
PG  - 154-6
AB  - A case report of a female newborn with a rare congenital abdominal wall defect
      associated with intestinal malformation. To our knowledge, only a few case
      reports of left sided congenital abdominal wall defect with this type of
      anomalies have been reported in the world literatures and this is the first in
      Fiji. This case brought numerous challenges to the team in terms of defining the 
      pathology, role of undertaking surgery, providing supportive and nutritional
      therapy to a neonate and the ethical dilemma with the management in a developing 
      country.
FAU - Cama, J
AU  - Cama J
AD  - Department of Medical Sciences, Fiji School of Medicine/Colonial War Memorial
      Hospital, Suva. Jitoko.Cama@fnu.ac.fj
FAU - Nagra, S
AU  - Nagra S
FAU - Chang, A
AU  - Chang A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - New Zealand
TA  - Pac Health Dialog
JT  - Pacific health dialog
JID - 9434923
SB  - IM
MH  - Abdominal Wall/*abnormalities
MH  - Abnormalities, Multiple/*surgery
MH  - Female
MH  - Fiji
MH  - Gastroschisis/*surgery
MH  - Humans
MH  - Infant, Newborn
MH  - Intestines/*abnormalities
EDAT- 2011/03/01 00:00
MHDA- 2012/10/19 06:00
CRDT- 2012/09/27 06:00
PHST- 2012/09/27 06:00 [entrez]
PHST- 2011/03/01 00:00 [pubmed]
PHST- 2012/10/19 06:00 [medline]
PST - ppublish
SO  - Pac Health Dialog. 2011 Mar;17(1):154-6.


PMID- 23008974
OWN - NLM
STAT- MEDLINE
DCOM- 20121018
LR  - 20171116
IS  - 1015-7867 (Print)
IS  - 1015-7867 (Linking)
VI  - 17
IP  - 1
DP  - 2011 Mar
TI  - 'Getting rid of tobacco...that's the key': strong feelings of Pacific
      policymakers in New Zealand about tobacco, and smoking around children.
PG  - 99-106
AB  - AIM: To further explore the views of New Zealand-based Pacific policymakers on
      smoking in general, smoking in public and private spaces, and smoking around
      children. METHODS: Key informants (n = 18) were recruited and interviewed by
      Pacific interviewers during May-October 2008, in person or by phone. RESULTS: The
      interviews revealed a great depth of feeling about smoking in general, smoking in
      public places, and smoking around children. There was considerable variance of
      opinion on the extent to which smokefree areas should be extended, with some
      informants reluctant to interfere with smokers' "choices" There was a general
      consensus that adults' right to smoke should be limited by social and ethical
      responsibilities to children. CONCLUSIONS: The strong feelings found in favour of
      tobacco control by some of the interviewees is notable. Mobilising such feelings 
      may help facilitate further progress for advancing tobacco control for Pacific
      communities in New Zealand and for assisting tobacco control in other South
      Pacific island nations.
FAU - Austin, Salote
AU  - Austin S
AD  - Department of Public Health, University of Otago, Wellington, New Zealand.
      austin@otago.ac.nz
FAU - Thomson, George
AU  - Thomson G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - New Zealand
TA  - Pac Health Dialog
JT  - Pacific health dialog
JID - 9434923
RN  - 0 (Tobacco Smoke Pollution)
SB  - IM
MH  - Administrative Personnel/*psychology
MH  - Adult
MH  - *Attitude
MH  - Child
MH  - Child Welfare/*legislation & jurisprudence
MH  - Child, Preschool
MH  - Federal Government
MH  - Female
MH  - Humans
MH  - Male
MH  - New Zealand/ethnology
MH  - Pacific Islands/ethnology
MH  - Smoking/*legislation & jurisprudence
MH  - *Smoking Prevention
MH  - Tobacco Smoke Pollution/*legislation & jurisprudence/*prevention & control
EDAT- 2011/03/01 00:00
MHDA- 2012/10/19 06:00
CRDT- 2012/09/27 06:00
PHST- 2012/09/27 06:00 [entrez]
PHST- 2011/03/01 00:00 [pubmed]
PHST- 2012/10/19 06:00 [medline]
PST - ppublish
SO  - Pac Health Dialog. 2011 Mar;17(1):99-106.


PMID- 22647202
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20140731
IS  - 1746-045X (Electronic)
IS  - 1746-0441 (Linking)
VI  - 6
IP  - 3
DP  - 2011 Mar
TI  - Nonhuman primates as models for the discovery and development of ebolavirus
      therapeutics.
PG  - 233-50
LID - 10.1517/17460441.2011.554815 [doi]
AB  - INTRODUCTION: Ebolaviruses are human pathogenic Category A priority pathogens for
      which no vaccines or therapeutics are currently licensed; however, several
      therapeutic agents have shown promising efficacy in nonhuman primate models of
      infection and are potential candidates for use in humans. Demonstration of
      efficacy in nonhuman primate models of ebolavirus infection will probably be
      central to the development and eventual licensure of ebolavirus medical
      countermeasures given the ethical and feasibility constraints of human efficacy
      assessments. AREAS COVERED: The authors describe ebolavirus hemorrhagic fever
      (EHF), with an emphasis on comparing human and nonhuman primate pathophysiology. 
      Published data examining human and animal clinical disease parameters,
      histopathological findings, and immune responses in fatal and nonfatal cases are 
      synthesized and evaluated. Importantly, the authors also introduce and describe
      the FDA Animal Efficacy Rule as well as recent advances in antiviral drug
      development strategies for the treatment of EHF. EXPERT OPINION:
      Well-characterized models of ebolavirus infection are currently under development
      and scrutiny as to their accuracy and utility for modeling fatal infection in
      humans. The advanced development and eventual licensure of therapeutic agents
      will require demonstration that mechanisms conferring protection in nonhuman
      primate models of infection are predictive of protective responses in humans.
FAU - Shurtleff, Amy C
AU  - Shurtleff AC
AD  - US Army Medical Research Institute of Infectious Diseases, Integrated Toxicology 
      Division, 1425 Porter Street, Fort Detrick, Frederick, MD 21702, USA +1 301 619
      4246 ; +1 541 754 3545 ; sina.bavari@us.army.mil.
FAU - Warren, Travis K
AU  - Warren TK
FAU - Bavari, Sina
AU  - Bavari S
LA  - eng
PT  - Journal Article
PL  - England
TA  - Expert Opin Drug Discov
JT  - Expert opinion on drug discovery
JID - 101295755
EDAT- 2011/03/01 00:00
MHDA- 2011/03/01 00:01
CRDT- 2012/06/01 06:00
PHST- 2012/06/01 06:00 [entrez]
PHST- 2011/03/01 00:00 [pubmed]
PHST- 2011/03/01 00:01 [medline]
AID - 10.1517/17460441.2011.554815 [doi]
PST - ppublish
SO  - Expert Opin Drug Discov. 2011 Mar;6(3):233-50. doi: 10.1517/17460441.2011.554815.


PMID- 21350931
OWN - NLM
STAT- MEDLINE
DCOM- 20120223
LR  - 20211020
IS  - 1543-0154 (Electronic)
IS  - 0885-8195 (Linking)
VI  - 26
IP  - 3
DP  - 2011 Sep
TI  - Professional development and the informal curriculum in end-of-life care.
PG  - 444-50
LID - 10.1007/s13187-011-0199-x [doi]
AB  - Although professionalism has emerged as a key competency for today's physicians, 
      there exists little insight into how best to teach medical students the relevant 
      skills or instill in them the commitment required to practice according to the
      highest professional standards. Ten UCSF medical students were interviewed at
      three time points (second, third, and fourth years of school). Interviews focused
      on students' learning and development regarding end-of-life care (EOLC). Students
      described varying steps in their professional development from their second to
      fourth years of school, including feeling confused about the definition of
      professionalism and integrating their personal and professional identities. In
      addition to professional development, four other themes contributed to the
      development of medical student understanding of how to provide EOLC as a
      professional: (1) curricular discordance, (2) role models, (3) the tightrope
      between trained versus human reactions, and (4) ethical dilemmas. These five
      themes represent dilemmas that students often learned how to respond to over the 
      course of school. Professional development in EOLC required the acquisition of
      skills necessary to balance the tension between and navigate conflicting messages
      present in medical student training.
FAU - Baker, Megan
AU  - Baker M
AD  - School of Medicine, University of California, San Francisco, San Francisco, CA
      94117, USA. megan.baker@ucsf.edu
FAU - Wrubel, Judith
AU  - Wrubel J
FAU - Rabow, Michael W
AU  - Rabow MW
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Cancer Educ
JT  - Journal of cancer education : the official journal of the American Association
      for Cancer Education
JID - 8610343
SB  - IM
MH  - Adult
MH  - *Curriculum
MH  - *Education, Medical, Undergraduate
MH  - Ethics, Clinical/*education
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Professional Competence/*standards
MH  - Students, Medical/*psychology
MH  - *Terminal Care
PMC - PMC3161185
EDAT- 2011/02/26 06:00
MHDA- 2012/02/24 06:00
CRDT- 2011/02/26 06:00
PHST- 2011/02/26 06:00 [entrez]
PHST- 2011/02/26 06:00 [pubmed]
PHST- 2012/02/24 06:00 [medline]
AID - 10.1007/s13187-011-0199-x [doi]
PST - ppublish
SO  - J Cancer Educ. 2011 Sep;26(3):444-50. doi: 10.1007/s13187-011-0199-x.


PMID- 21350895
OWN - NLM
STAT- MEDLINE
DCOM- 20120321
LR  - 20211020
IS  - 1433-2965 (Electronic)
IS  - 0937-941X (Linking)
VI  - 23
IP  - 1
DP  - 2012 Jan
TI  - Assessment of health claims in the field of bone: a view of the Group for the
      Respect of Ethics and Excellence in Science (GREES).
PG  - 193-9
LID - 10.1007/s00198-011-1561-x [doi]
AB  - UNLABELLED: Health claims for food products in Europe are permitted if the
      nutrient has been shown to have a beneficial nutritional or physiological effect.
      This paper defines health claims related to bone health and provides guidelines
      for the design and the methodology of clinical studies to support claims.
      INTRODUCTION: Regulation (EC) no. 1924/2006 on nutrition and health claims
      targeting food products was introduced in Europe stating that health claims shall
      only be permitted if the substance in respect of which the claim is made has been
      shown to have a beneficial nutritional or physiological effect. The objective of 
      this paper is to define health claims related to bone health and to provide
      guidelines for the design and the methodology of clinical studies which need to
      be adopted to assert such health claims. METHODS: Literature review followed by a
      consensus discussion during two 1-day meetings organized by the Group for the
      Respect of Ethics and Excellence in Science (GREES). RESULTS: The GREES
      identified six acceptable health claims related to bone health based on the
      potential of food products to show an effect on either the bioavailability of
      calcium or osteoclast regulatory proteins or bone turnover markers or bone
      mineral density or bone structure or fracture incidence. The GREES considers that
      well-designed human randomized controlled trial on a relevant outcome is the best
      design to assess health claims. The substantiation of health claim could also be 
      supported by animal studies showing either an improvement in bone strength with
      the food product or showing the relationship between changes induced by the food 
      product on a surrogate marker and changes in bone strength. CONCLUSION: The
      consensus reached is that the level of health claim may differ according to the
      surrogate endpoint used and on additional animal studies provided to support the 
      claim.
FAU - Bruyere, O
AU  - Bruyere O
AD  - Department of Public Health, Epidemiology and Health Economics, University of
      Liege, Liege, Belgium. olivier.bruyere@ulg.ac.be
FAU - Rizzoli, R
AU  - Rizzoli R
FAU - Coxam, V
AU  - Coxam V
FAU - Avouac, B
AU  - Avouac B
FAU - Chevalier, T
AU  - Chevalier T
FAU - Fabien-Soule, V
AU  - Fabien-Soule V
FAU - Kanis, J A
AU  - Kanis JA
FAU - Kaufman, J-M
AU  - Kaufman JM
FAU - Tsouderos, Y
AU  - Tsouderos Y
FAU - Reginster, J-Y
AU  - Reginster JY
LA  - eng
PT  - Consensus Development Conference
PT  - Journal Article
DEP - 20110225
PL  - England
TA  - Osteoporos Int
JT  - Osteoporosis international : a journal established as result of cooperation
      between the European Foundation for Osteoporosis and the National Osteoporosis
      Foundation of the USA
JID - 9100105
SB  - IM
MH  - Bone Density/physiology
MH  - Bone Remodeling/physiology
MH  - Bone and Bones/metabolism/*physiology
MH  - Europe
MH  - Evidence-Based Medicine/methods
MH  - Food Industry/legislation & jurisprudence
MH  - Functional Food/*standards
MH  - Guidelines as Topic
MH  - Humans
MH  - Legislation, Food
MH  - Nutritional Physiological Phenomena/*physiology
MH  - Research Design
PMC - PMC3249193
EDAT- 2011/02/26 06:00
MHDA- 2012/03/22 06:00
CRDT- 2011/02/26 06:00
PHST- 2011/01/04 00:00 [received]
PHST- 2011/01/26 00:00 [accepted]
PHST- 2011/02/26 06:00 [entrez]
PHST- 2011/02/26 06:00 [pubmed]
PHST- 2012/03/22 06:00 [medline]
AID - 10.1007/s00198-011-1561-x [doi]
PST - ppublish
SO  - Osteoporos Int. 2012 Jan;23(1):193-9. doi: 10.1007/s00198-011-1561-x. Epub 2011
      Feb 25.


PMID- 21350376
OWN - NLM
STAT- MEDLINE
DCOM- 20110707
LR  - 20211203
IS  - 1539-0683 (Electronic)
IS  - 0361-929X (Linking)
VI  - 36
IP  - 2
DP  - 2011 Mar-Apr
TI  - Sailing against the tide: Taiwanese women's journey from pregnancy loss to
      motherhood.
PG  - 127-33
LID - 10.1097/NMC.0b013e3182073629 [doi]
AB  - PURPOSE: To understand the experiences of Asian women in Taiwan who are adjusting
      to motherhood following previous pregnancy loss. STUDY DESIGN AND METHODS:
      Phenomenology was used as the study design, and interviews were used to collect
      data in a medical center in Northern Taiwan with six women who had given birth to
      a healthy baby after previous pregnancy loss. Following ethical approval,
      interviews were audio-recorded, transcribed, and analyzed to develop data themes.
      RESULTS: The nautical metaphor was chosen because of the fact that Taiwan is an
      island and surround by sea. The sea has deep cultural meaning of uncertainty in
      life for the Taiwanese people. A metaphor of "sailing against the tide" emerged
      from the data to depict three stages of the women's journey: remembering the
      previous journey of loss; the rising sun brings new life within; and changing
      tide brings new birth. The essence of their journey through the pregnancy and
      birth was a permutation of fear, uncertainty, and a deep desire for reassurance
      of fetal well-being. CLINICAL IMPLICATIONS: This study reinforces the
      difficulties that women have after a pregnancy loss, but examines it with a
      unique cultural focus. Nurses and midwives can use these findings to develop
      caring and understanding practices designed to help women in these circumstances.
      Pregnancy after a loss is never the same as a previous pregnancy, and is
      perceived as different from a pregnancy that other "normal" pregnant women have. 
      Women need nurses and midwives who can provide comprehensive practical, physical,
      culturally specific, psychosocial, and spiritual support to help them
      successfully chart their journey out of profound loss.
FAU - Sun, Hui-Lin
AU  - Sun HL
AD  - Mackay Medicine, Nursing and Management College, Taipei, Taiwan.
      mjcn130@hotmail.com
FAU - Sinclair, Marlene
AU  - Sinclair M
FAU - Kernohan, George W
AU  - Kernohan GW
FAU - Chang, Te-Hsin
AU  - Chang TH
FAU - Patterson, Hilary
AU  - Patterson H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - MCN Am J Matern Child Nurs
JT  - MCN. The American journal of maternal child nursing
JID - 7605941
SB  - IM
EIN - MCN Am J Matern Child Nurs. 2011 May-Jun;36(3):168. Paterson, Hillary [corrected 
      to Patterson, Hilary]
MH  - Abortion, Spontaneous/ethnology/*psychology
MH  - *Adaptation, Psychological
MH  - Asians/*psychology
MH  - Female
MH  - Grief
MH  - Humans
MH  - Mothers/*psychology
MH  - Pregnancy/ethnology/*psychology
MH  - Stillbirth/ethnology/*psychology
MH  - Taiwan
EDAT- 2011/02/26 06:00
MHDA- 2011/07/08 06:00
CRDT- 2011/02/26 06:00
PHST- 2011/02/26 06:00 [entrez]
PHST- 2011/02/26 06:00 [pubmed]
PHST- 2011/07/08 06:00 [medline]
AID - 10.1097/NMC.0b013e3182073629 [doi]
PST - ppublish
SO  - MCN Am J Matern Child Nurs. 2011 Mar-Apr;36(2):127-33. doi:
      10.1097/NMC.0b013e3182073629.


PMID- 21349800
OWN - NLM
STAT- MEDLINE
DCOM- 20110525
LR  - 20191210
IS  - 1769-6917 (Electronic)
IS  - 0007-4551 (Linking)
VI  - 98
IP  - 2
DP  - 2011 Feb
TI  - [Translation and validation of Brief Edinburgh Depression Scale (BEDS) in
      French].
PG  - 199-208
LID - 10.1684/bdc.2011.1310 [doi]
AB  - BACKGROUND: Depression is an important symptom for many palliative care patients 
      but is rarely identified. It's known to reduce quality of life and impact on
      palliation of physical symptom. These physical symptoms can be improved by an
      adequate treatment of depression. Many depressed cancer patients are not treated 
      due to the difficulty in assessment. The Brief Edinburgh Depression Scale (BEDS) 
      is widely used within the UK and also in other countries but its use is limited
      by the lack of translations. In this study, we report the translation and
      validation of the BEDS in French. METHOD: A group of experts translate the BEDS
      using back-to-back translation and the standard procedures of the EORTC. All the 
      patients admitted to our Palliative Care Unit between November 2007 and April
      2008 were eligible to take part in the study. The French BEDS was validated
      against the gold standard, a semi structured psychiatric interview (according to 
      the SADS ou Schedule for Affective Disorders Scale). For this study full regional
      ethical approval was obtained. RESULTS: Forty-eight patients participated in the 
      validation study. The prevalence of depression according to psychiatric interview
      was found to be 56.3% and the optimum cut-off of the French BEDS was 7, which
      yielded a sensitivity of 82.4% and a specificity of 68.4%. CONCLUSION: We believe
      that the French BEDS is a valid and sensitive tool for screening depression, and 
      that it can be used within the palliative care population. Further work might be 
      necessary to extend its use to the wider oncology population.
FAU - Rhondali, Wadih
AU  - Rhondali W
AD  - Hospices civils de Lyon, universite Lyon-I, domaine Rockefeller, France.
      wadihrhondali@gmail.com
FAU - Perceau, Elise
AU  - Perceau E
FAU - Saltel, Pierre
AU  - Saltel P
FAU - Girard, Raphaelle
AU  - Girard R
FAU - Filbet, Marilene
AU  - Filbet M
LA  - fre
PT  - Journal Article
PT  - Review
PT  - Validation Study
TT  - Validation linguistique et metrique de la version francaise de la Brief Edinburgh
      Depression Scale (BEDS).
PL  - France
TA  - Bull Cancer
JT  - Bulletin du cancer
JID - 0072416
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Brief Psychiatric Rating Scale/standards
MH  - Depression/*diagnosis
MH  - Female
MH  - Humans
MH  - *Language
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/*psychology/therapy
MH  - Palliative Care/*psychology
MH  - Psychometrics
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - *Translations
MH  - Young Adult
EDAT- 2011/02/26 06:00
MHDA- 2011/05/26 06:00
CRDT- 2011/02/26 06:00
PHST- 2011/02/26 06:00 [entrez]
PHST- 2011/02/26 06:00 [pubmed]
PHST- 2011/05/26 06:00 [medline]
AID - 10.1684/bdc.2011.1310 [doi]
AID - S0007-4551(15)30687-1 [pii]
PST - ppublish
SO  - Bull Cancer. 2011 Feb;98(2):199-208. doi: 10.1684/bdc.2011.1310.


PMID- 21349754
OWN - NLM
STAT- MEDLINE
DCOM- 20110803
LR  - 20110307
IS  - 1579-2013 (Electronic)
IS  - 1130-8621 (Linking)
VI  - 21
IP  - 1
DP  - 2011 Jan-Feb
TI  - [Ethical conflicts over verbal statements regarding last wishes].
PG  - 47-51
LID - 10.1016/j.enfcli.2010.07.009 [doi]
AB  - Within our socio-professional framework, there are few occasions in which there
      is sincere communication between health care teams and patients and their
      families that allows questions to be raised about decisions made during the
      process of an illness i.e., whether an intervention, or its omission in certain
      cases, would be accepted. Decisions regarding representation or living wills are 
      merely an extension of the inclusion of the patients' moral autonomy in clinical 
      decision making. Nevertheless, the best way to make patients' rights effective is
      not by focussing on these documents, but rather by achieving the development of
      integral processes that promote patient participation and decision making. On the
      basis of a discussion in which a number of ethical conflicts that concern
      patients' last wishes are intertwined, we present the following clinical case
      that allows reflection on the most effective kind of intervention, the nature of 
      its duration and intensity and the way health care professionals must be faithful
      to patients' and families' desires and expressions in these cases.
CI  - Copyright (c) 2010 Elsevier Espana, S.L. All rights reserved.
FAU - Perello-Campaner, Catalina
AU  - Perello-Campaner C
AD  - Departamento de Enfermeria y Fisioterapia, Universitat de les Illes Balears,
      Palma de Mallorca, Baleares, Espana. c.perello@uib.es
FAU - Molina-Mula, Jesus
AU  - Molina-Mula J
FAU - Miro-Bonet, Rosa
AU  - Miro-Bonet R
LA  - spa
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - Conflictos eticos ante la manifestacion verbal de las ultimas voluntades.
DEP - 20110223
PL  - Spain
TA  - Enferm Clin
JT  - Enfermeria clinica
JID - 101190915
SB  - IM
MH  - Advance Directives/*ethics
MH  - Aged
MH  - Humans
MH  - Male
MH  - Verbal Behavior
EDAT- 2011/02/26 06:00
MHDA- 2011/08/04 06:00
CRDT- 2011/02/26 06:00
PHST- 2010/04/27 00:00 [received]
PHST- 2010/07/12 00:00 [revised]
PHST- 2010/07/27 00:00 [accepted]
PHST- 2011/02/26 06:00 [entrez]
PHST- 2011/02/26 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
AID - S1130-8621(10)00191-9 [pii]
AID - 10.1016/j.enfcli.2010.07.009 [doi]
PST - ppublish
SO  - Enferm Clin. 2011 Jan-Feb;21(1):47-51. doi: 10.1016/j.enfcli.2010.07.009. Epub
      2011 Feb 23.


PMID- 21349646
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20161125
IS  - 1879-1409 (Electronic)
IS  - 0305-4179 (Linking)
VI  - 37
IP  - 5
DP  - 2011 Aug
TI  - Randomized controlled single center study comparing a polyhexanide containing
      bio-cellulose dressing with silver sulfadiazine cream in partial-thickness dermal
      burns.
PG  - 800-4
LID - 10.1016/j.burns.2011.01.027 [doi]
AB  - OBJECTIVE: A prospective, randomized, controlled single center study was designed
      to evaluate clinical efficacy of a polyhexanide containing bio-cellulose dressing
      (group B) compared to a silver-sulfadiazine cream (group A) in sixty
      partial-thickness burn patients. PATIENTS AND METHODS: Local ethics committee
      approval was obtained and patients consented. Parameters were: pain reduction
      (VAS), healing time and wound bed condition, comparing day 0 (start) versus day
      14 (end), as well as, ease of dressing use and treatment costs. RESULTS: All
      completed the study (n=30/n=30) and were included in the ITT analysis, with a
      total of 72 burns (group A: n=38, group B: n=34). We noted no differences in
      healing time. Pain reduction was significantly faster and better in group B
      (p<0.01). There were fewer dressing changes in group B, compared to group A. Ease
      of use for the bio-cellulose dressing was rated better compared to group A. In
      group B, euro 95.20 was saved for a 10 day treatment period, compared to group A.
      CONCLUSION: Group B demonstrated a better and faster pain reduction in the
      treated partial-thickness burns, compared to group A. The results indicate the
      polyhexanide containing bio-cellulose dressing to be a safe and cost effective
      treatment for partial-thickness burns.
CI  - Copyright (c) 2011 Elsevier Ltd and ISBI. All rights reserved.
FAU - Piatkowski, A
AU  - Piatkowski A
AD  - Department of Plastic Surgery and Hand Surgery-Burn Unit, RWTH-University
      Hospital Aachen, Pauwelsstr. 30, 52057 Aachen, Germany. apiatkowski@ukaachen.de
FAU - Drummer, N
AU  - Drummer N
FAU - Andriessen, A
AU  - Andriessen A
FAU - Ulrich, D
AU  - Ulrich D
FAU - Pallua, N
AU  - Pallua N
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20110223
PL  - Netherlands
TA  - Burns
JT  - Burns : journal of the International Society for Burn Injuries
JID - 8913178
RN  - 0 (Anti-Infective Agents, Local)
RN  - 0 (Biguanides)
RN  - 0 (Biocompatible Materials)
RN  - 322U039GMF (polihexanide)
RN  - 9004-34-6 (Cellulose)
RN  - W46JY43EJR (Silver Sulfadiazine)
SB  - IM
MH  - Adult
MH  - Anti-Infective Agents, Local/*therapeutic use
MH  - *Bandages/economics
MH  - Biguanides/therapeutic use
MH  - Biocompatible Materials/economics/*therapeutic use
MH  - Burns/drug therapy/economics/*therapy
MH  - Cellulose/*therapeutic use
MH  - Female
MH  - Health Care Costs
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pain Measurement
MH  - Prospective Studies
MH  - Silver Sulfadiazine/*therapeutic use
MH  - Wound Healing/drug effects
MH  - Young Adult
EDAT- 2011/02/26 06:00
MHDA- 2011/10/25 06:00
CRDT- 2011/02/26 06:00
PHST- 2010/11/23 00:00 [received]
PHST- 2011/01/24 00:00 [revised]
PHST- 2011/01/26 00:00 [accepted]
PHST- 2011/02/26 06:00 [entrez]
PHST- 2011/02/26 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
AID - S0305-4179(11)00049-0 [pii]
AID - 10.1016/j.burns.2011.01.027 [doi]
PST - ppublish
SO  - Burns. 2011 Aug;37(5):800-4. doi: 10.1016/j.burns.2011.01.027. Epub 2011 Feb 23.


PMID- 21349593
OWN - NLM
STAT- MEDLINE
DCOM- 20120329
LR  - 20220408
IS  - 1872-6976 (Electronic)
IS  - 0167-4943 (Linking)
VI  - 54
IP  - 1
DP  - 2012 Jan-Feb
TI  - Designing robots for the elderly: appearance issue and beyond.
PG  - 121-6
LID - 10.1016/j.archger.2011.02.003 [doi]
AB  - This paper provides the results of three focus groups organized in the framework 
      of the ROBADOM project, aiming at designing a service type assistive robot for
      the elderly with mild cognitive impairment living at home. The main objective of 
      these focus groups was to give some recommendations to engineers in charge of the
      design of the robot's appearance. Results showed that although many humanoid
      robots were criticized by most participants, some small creative humanoid robots 
      were appreciated. However, beyond the issue of the robot appearance, many ethical
      and social issues were raised. These focus groups offered an opportunity for
      participants to discuss the very idea of an assistive robot and to challenge some
      implicit preconceptions of the roboticists. Finally, we discuss how assistive
      robots could be designed considering the social context of the elderly and how to
      implicate the elderly as future end-users in the design process.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Wu, Ya-Huei
AU  - Wu YH
AD  - Assistance Publique-Hopitaux de Paris (APHP), Hopital Broca & Research Team 4468,
      Paris Descartes University, 54-56, rue Pascal, 75013 Paris, France.
      yahuei.wu@brc.aphp.fr
FAU - Fassert, Christine
AU  - Fassert C
FAU - Rigaud, Anne-Sophie
AU  - Rigaud AS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110223
PL  - Netherlands
TA  - Arch Gerontol Geriatr
JT  - Archives of gerontology and geriatrics
JID - 8214379
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Attitude
MH  - Equipment Design
MH  - Esthetics
MH  - Female
MH  - Focus Groups
MH  - Humans
MH  - Male
MH  - *Robotics
MH  - User-Computer Interface
EDAT- 2011/02/26 06:00
MHDA- 2012/03/30 06:00
CRDT- 2011/02/26 06:00
PHST- 2010/09/03 00:00 [received]
PHST- 2011/01/24 00:00 [revised]
PHST- 2011/01/25 00:00 [accepted]
PHST- 2011/02/26 06:00 [entrez]
PHST- 2011/02/26 06:00 [pubmed]
PHST- 2012/03/30 06:00 [medline]
AID - S0167-4943(11)00028-8 [pii]
AID - 10.1016/j.archger.2011.02.003 [doi]
PST - ppublish
SO  - Arch Gerontol Geriatr. 2012 Jan-Feb;54(1):121-6. doi:
      10.1016/j.archger.2011.02.003. Epub 2011 Feb 23.


PMID- 21349192
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20211020
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 12
DP  - 2011 Feb 24
TI  - A comparison between diuretics and angiotensin-receptor blocker agents in
      patients with stage I hypertension (PREVER-treatment trial): study protocol for a
      randomized double-blind controlled trial.
PG  - 53
LID - 10.1186/1745-6215-12-53 [doi]
AB  - BACKGROUND: Cardiovascular disease is the leading cause of death in Brazil, and
      hypertension is its major risk factor. The benefit of its drug treatment to
      prevent major cardiovascular events was consistently demonstrated.
      Angiotensin-receptor blockers (ARB) have been the preferential drugs in the
      management of hypertension worldwide, despite the absence of any consistent
      evidence of advantage over older agents, and the concern that they may be
      associated with lower renal protection and risk for cancer. Diuretics are as
      efficacious as other agents, are well tolerated, have longer duration of action
      and low cost, but have been scarcely compared with ARBs. A study comparing
      diuretic and ARB is therefore warranted. METHODS/DESIGN: This is a randomized,
      double-blind, clinical trial, comparing the association of chlorthalidone and
      amiloride with losartan as first drug option in patients aged 30 to 70 years,
      with stage I hypertension. The primary outcomes will be variation of blood
      pressure by time, adverse events and development or worsening of microalbuminuria
      and of left ventricular hypertrophy in the EKG. The secondary outcomes will be
      fatal or non-fatal cardiovascular events: myocardial infarction, stroke, heart
      failure, evidence of new subclinical atherosclerosis and sudden death. The study 
      will last 18 months. The sample size will be of 1200 participants for group in
      order to confer enough power to test for all primary outcomes. The project was
      approved by the Ethics committee of each participating institution. DISCUSSION:
      The putative pleiotropic effects of ARB agents, particularly renal protection,
      have been disputed, and they have been scarcely compared with diuretics in large 
      clinical trials, despite that they have been at least as efficacious as newer
      agents in managing hypertension. Even if the null hypothesis is not rejected, the
      information will be useful for health care policy to treat hypertension in
      Brazil. CLINICAL TRIALS REGISTRATION NUMBER: ClinicalTrials.gov: NCT00971165.
FAU - Fuchs, Flavio D
AU  - Fuchs FD
AD  - Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, 
      Porto Alegre, Brazil. ffuchs@hcpa.ufrgs.br
FAU - Fuchs, Sandra C
AU  - Fuchs SC
FAU - Moreira, Leila B
AU  - Moreira LB
FAU - Gus, Miguel
AU  - Gus M
FAU - Nobrega, Antonio C
AU  - Nobrega AC
FAU - Poli-de-Figueiredo, Carlos E
AU  - Poli-de-Figueiredo CE
FAU - Mion, Decio
AU  - Mion D
FAU - Bortolotto, Luiz
AU  - Bortolotto L
FAU - Consolim-Colombo, Fernanda
AU  - Consolim-Colombo F
FAU - Nobre, Fernando
AU  - Nobre F
FAU - Coelho, Eduardo Barbosa
AU  - Coelho EB
FAU - Vilela-Martin, Jose F
AU  - Vilela-Martin JF
FAU - Moreno, Heitor Jr
AU  - Moreno H Jr
FAU - Cesarino, Evandro Jose
AU  - Cesarino EJ
FAU - Franco, Roberto
AU  - Franco R
FAU - Brandao, Andrea Araujo
AU  - Brandao AA
FAU - de Sousa, Marcos R
AU  - de Sousa MR
FAU - Ribeiro, Antonio Luiz Pinho
AU  - Ribeiro AL
FAU - Jardim, Paulo Cesar
AU  - Jardim PC
FAU - Afiune Neto, Abrahao
AU  - Afiune Neto A
FAU - Scala, Luiz Cesar N
AU  - Scala LC
FAU - Mota, Marco
AU  - Mota M
FAU - Chaves, Hilton
AU  - Chaves H
FAU - Alves, Joao Guilherme
AU  - Alves JG
FAU - Sobral Filho, Dario C
AU  - Sobral Filho DC
FAU - Pereira e Silva, Ricardo
AU  - Pereira e Silva R
FAU - Figueiredo Neto, Jose A
AU  - Figueiredo Neto JA
FAU - Irigoyen, Maria Claudia
AU  - Irigoyen MC
FAU - Castro, Iran
AU  - Castro I
FAU - Steffens, Andre Avelino
AU  - Steffens AA
FAU - Schlatter, Rosane
AU  - Schlatter R
FAU - de Mello, Renato Bandeira
AU  - de Mello RB
FAU - Mosele, Francisca
AU  - Mosele F
FAU - Ghizzoni, Flavia
AU  - Ghizzoni F
FAU - Berwanger, Otavio
AU  - Berwanger O
LA  - eng
SI  - ClinicalTrials.gov/NCT00971165
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110224
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
RN  - 0 (Angiotensin II Type 1 Receptor Blockers)
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Diuretics)
RN  - 7DZO8EB0Z3 (Amiloride)
RN  - JMS50MPO89 (Losartan)
RN  - Q0MQD1073Q (Chlorthalidone)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Amiloride/adverse effects/*therapeutic use
MH  - Angiotensin II Type 1 Receptor Blockers/adverse effects/*therapeutic use
MH  - Antihypertensive Agents/adverse effects/*therapeutic use
MH  - Blood Pressure/*drug effects
MH  - Brazil
MH  - Chlorthalidone/adverse effects/*therapeutic use
MH  - Diuretics/adverse effects/*therapeutic use
MH  - Double-Blind Method
MH  - Drug Therapy, Combination
MH  - Female
MH  - Humans
MH  - Hypertension/*drug therapy/physiopathology
MH  - Losartan/adverse effects/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - *Research Design
MH  - Severity of Illness Index
MH  - Time Factors
MH  - Treatment Outcome
PMC - PMC3056809
EDAT- 2011/02/26 06:00
MHDA- 2011/06/29 06:00
CRDT- 2011/02/26 06:00
PHST- 2010/12/08 00:00 [received]
PHST- 2011/02/24 00:00 [accepted]
PHST- 2011/02/26 06:00 [entrez]
PHST- 2011/02/26 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
AID - 1745-6215-12-53 [pii]
AID - 10.1186/1745-6215-12-53 [doi]
PST - epublish
SO  - Trials. 2011 Feb 24;12:53. doi: 10.1186/1745-6215-12-53.


PMID- 21349187
OWN - NLM
STAT- MEDLINE
DCOM- 20110502
LR  - 20211020
IS  - 1747-5341 (Electronic)
IS  - 1747-5341 (Linking)
VI  - 6
DP  - 2011 Feb 24
TI  - The being of leadership.
PG  - 5
LID - 10.1186/1747-5341-6-5 [doi]
AB  - The ethical foundation of the medical profession, which values service above
      reward and holds the doctor-patient relationship as inviolable, continues to be
      challenged by the commercialization of health care. This article contends that a 
      realigned leadership framework - one that distinguishes being a leader as the
      ontological basis for what leaders know, have, and do - is central to
      safeguarding medicine's ethical foundation. Four ontological pillars of
      leadership - awareness, commitment, integrity, and authenticity - are proposed as
      fundamental elements that anchor this foundation and the basic tenets of
      professionalism. Ontological leadership is shaped by and accessible through
      language; what health care leaders create in language "uses" them by providing a 
      point of view (a context) within and from which they orient their conversations, 
      decisions, and conduct such that they are ethically aligned and grounded. This
      contextual leadership framework exposes for us the limitations imposed by our
      mental maps, creating new opportunity sets for being and action (previously
      unavailable) that embody medicine's charter on professionalism. While this
      leadership methodology contrasts with the conventional results-oriented model
      where leading is generally equated with a successful clinical practice, a
      distinguished research program, or a promotion, it is not a replacement for it;
      indeed, results are essential for performance. Rather, being and action are
      interrelated and their correlated nature equips leaders with a framework for
      tackling health care's most complex problems in a manner that preserves
      medicine's venerable ethical heritage.
FAU - Souba, Wiley W
AU  - Souba WW
AD  - School of Medicine, Dartmouth College, Dartmouth Medical School, Hanover, NH,
      USA. chip.souba@dartmouth.edu
LA  - eng
PT  - Journal Article
DEP - 20110224
PL  - England
TA  - Philos Ethics Humanit Med
JT  - Philosophy, ethics, and humanities in medicine : PEHM
JID - 101258058
SB  - IM
MH  - *Ethics, Medical
MH  - Humans
MH  - *Leadership
MH  - *Philosophy
MH  - *Social Responsibility
PMC - PMC3050817
EDAT- 2011/02/26 06:00
MHDA- 2011/05/03 06:00
CRDT- 2011/02/26 06:00
PHST- 2010/03/29 00:00 [received]
PHST- 2011/02/24 00:00 [accepted]
PHST- 2011/02/26 06:00 [entrez]
PHST- 2011/02/26 06:00 [pubmed]
PHST- 2011/05/03 06:00 [medline]
AID - 1747-5341-6-5 [pii]
AID - 10.1186/1747-5341-6-5 [doi]
PST - epublish
SO  - Philos Ethics Humanit Med. 2011 Feb 24;6:5. doi: 10.1186/1747-5341-6-5.


PMID- 21349184
OWN - NLM
STAT- MEDLINE
DCOM- 20110630
LR  - 20220317
IS  - 1471-2458 (Electronic)
IS  - 1471-2458 (Linking)
VI  - 11
DP  - 2011 Feb 24
TI  - Testing the effectiveness of a mindfulness-based intervention to reduce emotional
      distress in outpatients with diabetes (DiaMind): design of a randomized
      controlled trial.
PG  - 131
LID - 10.1186/1471-2458-11-131 [doi]
AB  - BACKGROUND: Approximately 20-40% of outpatients with diabetes experience elevated
      levels of emotional distress, varying from disease-specific distress to general
      symptoms of anxiety and depression. The patient's emotional well-being is related
      to other unfavorable outcomes, like reduced quality of life, sub-optimal
      self-care, impaired glycemic control, higher risk of complications, and increased
      mortality rates. The purpose of this study is to test the effectiveness of a new 
      diabetes-specific, mindfulness-based psychological intervention. First, with
      regard to reducing emotional distress; second, with respect to improving quality 
      of life, dispositional mindfulness, and self-esteem of patients with diabetes;
      third, with regard to self-care and clinical outcomes; finally, a potential
      effect modification by clinical and personality characteristics will be explored.
      METHODS/DESIGN: The Diabetes and Mindfulness study (DiaMind) is a randomized
      controlled trial. Patients with diabetes with low levels of emotional well-being 
      will be recruited from outpatient diabetes clinics. Eligible patients will be
      randomized to an intervention group or a wait-list control group. The
      intervention group will receive the mindfulness program immediately, while the
      control group will receive the program eight months later. The primary outcome is
      emotional distress (anxiety, stress, depressive symptoms), for which data will be
      collected at baseline, four weeks, post intervention, and after six months
      follow-up. In addition, self-report data will be collected on quality of life,
      dispositional mindfulness, self-esteem, self-care, and personality, while
      complications and glycemic control will be assessed from medical files and blood 
      pressure will be measured. Group differences will be analyzed with repeated
      measures analysis of covariance.The study is supported by grants from the Dutch
      Diabetes Research Foundation and Tilburg University and has been approved by a
      medical ethics committee. DISCUSSION: It is hypothesized that emotional
      well-being, quality of life, dispositional mindfulness, self-esteem, self-care,
      and blood pressure will improve significantly more in the mindfulness group
      compared to the control group. Results of this study can contribute to a better
      care for patients with diabetes with lowered levels of emotional well-being. It
      is expected that the first results will become available in 2012. TRIAL
      REGISTRATION: Dutch Trial Register NTR2145.
FAU - van Son, Jenny
AU  - van Son J
AD  - Center of Research on Psychology in Somatic diseases (CoRPS), Department of
      Medical Psychology and Neuropsychology, Tilburg University, Tilburg, The
      Netherlands.
FAU - Nyklicek, Ivan
AU  - Nyklicek I
FAU - Pop, Victor J M
AU  - Pop VJ
FAU - Pouwer, Francois
AU  - Pouwer F
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110224
PL  - England
TA  - BMC Public Health
JT  - BMC public health
JID - 100968562
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Awareness
MH  - Cognitive Behavioral Therapy
MH  - Diabetes Mellitus/physiopathology/*psychology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Netherlands
MH  - Outpatients/*psychology
MH  - *Research Design
MH  - Stress, Psychological/*prevention & control
MH  - Surveys and Questionnaires
MH  - Young Adult
PMC - PMC3053244
EDAT- 2011/02/26 06:00
MHDA- 2011/07/01 06:00
CRDT- 2011/02/26 06:00
PHST- 2011/01/17 00:00 [received]
PHST- 2011/02/24 00:00 [accepted]
PHST- 2011/02/26 06:00 [entrez]
PHST- 2011/02/26 06:00 [pubmed]
PHST- 2011/07/01 06:00 [medline]
AID - 1471-2458-11-131 [pii]
AID - 10.1186/1471-2458-11-131 [doi]
PST - epublish
SO  - BMC Public Health. 2011 Feb 24;11:131. doi: 10.1186/1471-2458-11-131.


PMID- 21349182
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1744-8603 (Electronic)
IS  - 1744-8603 (Linking)
VI  - 7
DP  - 2011 Feb 24
TI  - State strategies of governance in biomedical innovation: aligning conceptual
      approaches for understanding 'Rising Powers' in the global context.
PG  - 3
LID - 10.1186/1744-8603-7-3 [doi]
AB  - BACKGROUND: 'Innovation' has become a policy focus in its own right in many
      states as they compete to position themselves in the emerging knowledge
      economies. Innovation in biomedicine is a global enterprise in which 'Rising
      Power' states figure prominently, and which undoubtedly will re-shape health
      systems and health economies globally. Scientific and technological innovation
      processes and policies raise difficult issues in the domains of
      science/technology, civil society, and the economic and healthcare marketplace.
      The production of knowledge in these fields is complex, uncertain,
      inter-disciplinary and inter-institutional, and subject to a continuing political
      struggle for advantage. As part of this struggle, a wide variety of issues -
      regulation, intellectual property, ethics, scientific boundaries, healthcare
      market formation - are raised and policy agendas negotiated. METHODS: A range of 
      social science disciplines and approaches have conceptualised such innovation
      processes. Against a background of concepts such as the competition state and the
      developmental state, and national innovation systems, we give an overview of a
      range of approaches that have potential for advancing understanding of governance
      of global life science and biomedical innovation, with special reference to the
      'Rising Powers', in order to examine convergences and divergences between them.
      Conceptual approaches that we focus on include those drawn from political
      science/political economy, sociology of technology; Innovation Studies and
      Science & Technology Studies. The paper is part of a project supported by the UK 
      ESRC's Rising Powers programme. RESULTS: We show convergences and
      complementarities between the approaches discussed, and argue that the role of
      the national state itself has become relatively neglected in much of the relevant
      theorising. CONCLUSIONS: We conclude that an approach is required that enables
      innovation and governance to be seen as 'co-producing' each other in a
      multi-level, global ecology of innovation, taking account of the particular,
      differing characteristics of different emerging scientific fields and
      technologies. We suggest key points to take account of in order in the future to 
      move toward a satisfactory integrative conceptual framework, capable of better
      understanding the processes of the emergence, state steerage and transnational
      governance of innovative biomedical sectors in the Rising Powers and global
      context.
FAU - Salter, Brian
AU  - Salter B
AD  - Department of Political Economy, King's College London, Strand, London WC2R 2LS, 
      UK. alex.faulkner@kcl.ac.uk.
FAU - Faulkner, Alex
AU  - Faulkner A
LA  - eng
PT  - Journal Article
DEP - 20110224
PL  - England
TA  - Global Health
JT  - Globalization and health
JID - 101245734
PMC - PMC3049135
EDAT- 2011/02/26 06:00
MHDA- 2011/02/26 06:01
CRDT- 2011/02/26 06:00
PHST- 2010/10/09 00:00 [received]
PHST- 2011/02/24 00:00 [accepted]
PHST- 2011/02/26 06:00 [entrez]
PHST- 2011/02/26 06:00 [pubmed]
PHST- 2011/02/26 06:01 [medline]
AID - 1744-8603-7-3 [pii]
AID - 10.1186/1744-8603-7-3 [doi]
PST - epublish
SO  - Global Health. 2011 Feb 24;7:3. doi: 10.1186/1744-8603-7-3.


PMID- 21348929
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20191210
IS  - 1939-3938 (Electronic)
IS  - 1556-3693 (Linking)
VI  - 7
IP  - 1
DP  - 2011 Mar
TI  - Respect in forensic psychiatric nurse-patient relationships: a practical
      compromise.
PG  - 3-16
LID - 10.1111/j.1939-3938.2010.01090.x [doi]
AB  - The context of forensic psychiatric nursing is distinct from other psychiatric
      settings as, it involves placement of patients in secure environments with
      restrictions determined by the courts. Previous literature has identified that
      nurses morally struggle with respecting patients who have committed heinous
      offences, which can lead to the patient being depersonalized and dehumanized.
      Although respect is fundamental to ethical nursing practice, it has not been
      adequately explored conceptually or empirically. As a result, little knowledge
      exists that identifies how nurses develop, maintain, and express respect for
      patients. The purpose of this study is to analyze the concept of respect
      systematically, from a forensic psychiatric nurse's perspective using the
      qualitative methodology of focused ethnography. Forensic psychiatric nurses were 
      recruited from two medium secure forensic rehabilitation units. In the first
      interview, 13 registered nurses (RNs) and two registered practical nurses (RPNs) 
      participated, and although all informants were invited to the second interview,
      six RNs were lost to follow-up. Despite this loss, saturation was achieved and
      the data were interpreted through a feminist philosophical lens. Respect was
      influenced by factors categorized into four themes: (1) emotive-cognitive
      reactions, (2) nonjudgmental approach, (3) social identity and power, and (4)
      context. The data from the themes indicate that forensic psychiatric nurses
      strike a practical compromise, in their understanding and enactment of respect in
      therapeutic relationships with forensic psychiatric patients.
CI  - (c) 2011 International Association of Forensic Nurses.
FAU - Rose, Donald N
AU  - Rose DN
AD  - Daphne Cockwell School of Nursing, Faculty of Community Services, Ryerson
      University Toronto, ON, Canada. donrose@ryerson.ca
FAU - Peter, Elizabeth
AU  - Peter E
FAU - Gallop, Ruth
AU  - Gallop R
FAU - Angus, Jan E
AU  - Angus JE
FAU - Liaschenko, Joan
AU  - Liaschenko J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Forensic Nurs
JT  - Journal of forensic nursing
JID - 101234500
SB  - IM
MH  - Anthropology, Cultural
MH  - Empathy
MH  - Empirical Research
MH  - Fear
MH  - *Forensic Nursing
MH  - Humans
MH  - Interviews as Topic
MH  - Morals
MH  - *Nurse-Patient Relations
MH  - Power, Psychological
MH  - *Psychiatric Nursing
MH  - Social Identification
MH  - Trust
EDAT- 2011/02/26 06:00
MHDA- 2011/06/29 06:00
CRDT- 2011/02/26 06:00
PHST- 2011/02/26 06:00 [entrez]
PHST- 2011/02/26 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
AID - 10.1111/j.1939-3938.2010.01090.x [doi]
PST - ppublish
SO  - J Forensic Nurs. 2011 Mar;7(1):3-16. doi: 10.1111/j.1939-3938.2010.01090.x.


PMID- 21348904
OWN - NLM
STAT- MEDLINE
DCOM- 20110907
LR  - 20211020
IS  - 1369-7625 (Electronic)
IS  - 1369-6513 (Linking)
VI  - 14
IP  - 2
DP  - 2011 Jun
TI  - Personal financial incentives in health promotion: where do they fit in an ethic 
      of autonomy?
PG  - 191-200
LID - 10.1111/j.1369-7625.2011.00664.x [doi]
AB  - AIM: This paper reviews the ethical controversy concerning the use of monetary
      incentives in health promotion, focussing specifically on the arguments relating 
      to the impact on personal autonomy of such incentives. BACKGROUND: Offering
      people small amounts of money in the context of health promotion and medical care
      has been attempted in a number of settings in recent years. This use of personal 
      financial incentives has attracted a degree of ethical controversy. One form of
      criticism is that such schemes interfere with the autonomy of the patient or
      citizen in an illegitimate way. METHODS: This paper presents a thematic analysis 
      of the main arguments concerning personal autonomy and the use of monetary
      incentives in behaviour change. RESULTS: The main moral objections to the uses of
      incentives are that they may be in general or in specific instances
      paternalistic, coercive, involve bribery, or undermine the agency of the person. 
      CONCLUSION: While incentive schemes may engage these problems on occasion, there 
      is no good reason to think that they do so inherently and of necessity. We need
      better behavioural science evidence to understand how incentives work, in order
      to evaluate their moral effects in practice.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Ashcroft, Richard E
AU  - Ashcroft RE
AD  - Queen Mary University of London, School of Law, London, UK. r.ashcroft@qmul.ac.uk
LA  - eng
GR  - 086031/Wellcome Trust/United Kingdom
GR  - WT086031MF/WT_/Wellcome Trust/United Kingdom
PT  - Comment
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110223
PL  - England
TA  - Health Expect
JT  - Health expectations : an international journal of public participation in health 
      care and health policy
JID - 9815926
SB  - IM
CON - Health Expect. 2011 Jun;14(2):178-81. PMID: 21592263
MH  - Coercion
MH  - Ethics
MH  - Health Behavior
MH  - *Health Promotion/economics
MH  - Humans
MH  - *Moral Obligations
MH  - *Motivation
MH  - *Personal Autonomy
MH  - Social Responsibility
PMC - PMC3123700
EDAT- 2011/02/26 06:00
MHDA- 2011/09/08 06:00
CRDT- 2011/02/26 06:00
PHST- 2011/02/26 06:00 [entrez]
PHST- 2011/02/26 06:00 [pubmed]
PHST- 2011/09/08 06:00 [medline]
AID - 10.1111/j.1369-7625.2011.00664.x [doi]
PST - ppublish
SO  - Health Expect. 2011 Jun;14(2):191-200. doi: 10.1111/j.1369-7625.2011.00664.x.
      Epub 2011 Feb 23.


PMID- 21348764
OWN - NLM
STAT- MEDLINE
DCOM- 20110811
LR  - 20220318
IS  - 1557-8674 (Electronic)
IS  - 1096-2964 (Linking)
VI  - 12
IP  - 2
DP  - 2011 Apr
TI  - Peritonitis in children: our experience in Benin City, Nigeria.
PG  - 127-30
LID - 10.1089/sur.2010.046 [doi]
AB  - BACKGROUND: Peritonitis is a surgical emergency of variable etiology with a high 
      mortality rate, particularly in children. This paper reports our experience with 
      the epidemiology and outcome of management of childhood peritonitis in an African
      setting. PATIENTS AND METHODS: Consecutive children with peritonitis managed over
      six years (2004-2009) at the University of Benin Teaching Hospital, Nigeria, were
      included in this prospective experience after approval by the local Ethics
      Committee. RESULTS: Of the 721 children aged between one day and 18 years (mean 5
      +/- 4.2 years), comprising 415 males and 306 females (male/female ratio 1.4:1)
      who were managed for gastrointestinal disease, 182 (25.2%) developed peritonitis,
      179 (98.4%) preoperatively and three (1.6%) postoperatively. Secondary bacterial 
      peritonitis most often followed complicated appendicitis (120; 65.9%),
      intussusception (13; 7.1%), volvulus (5; 2.7%), and intestinal atresia (4; 2.2%).
      Peritonitis was generalized in all children younger than 11 years but less so
      after that age, and the outcome was poorest in neonatal infants, who accounted
      for 14 (63.6%) of the 18 peritonitis-related deaths (p < 0.0001). All the
      children had thorough peritoneal irrigation and lavage that included the
      insertion of drains in cases of localized peritonitis. The choice of antibiotics 
      and additional surgical options that included bowel resection and anastomosis,
      stoma creation, and closure of perforation depended on the primary pathology and 
      bacteriology findings. The duration of hospitalization was increased to between
      seven days in older children with localized peritonitis and 25 days in neonatal
      infants with generalized peritonitis compared with 3-5 days in children with
      similar pathology who did not have peritonitis (p < 0.0001). CONCLUSION:
      Peritonitis was severe and generalized in younger children, especially neonatal
      infants, who accounted for the majority of the deaths recorded. Early referral of
      children, particularly neonatal infants, having gastrointestinal complaints for
      surgical consultation and prompt surgical management is recommended to prevent
      peritonitis and to improve the outcome of children with the disease.
FAU - Osifo, Osarumwense D
AU  - Osifo OD
AD  - Pediatric Surgery Unit, Department of Surgery, University of Benin Teaching
      Hospital, Benin City, Nigeria. Leadekso@yahoo.com
FAU - Ogiemwonyi, Scott O
AU  - Ogiemwonyi SO
LA  - eng
PT  - Journal Article
DEP - 20110224
PL  - United States
TA  - Surg Infect (Larchmt)
JT  - Surgical infections
JID - 9815642
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Nigeria/epidemiology
MH  - Peritonitis/*epidemiology/mortality/pathology/*surgery
MH  - Prospective Studies
MH  - Treatment Outcome
EDAT- 2011/02/26 06:00
MHDA- 2011/08/13 06:00
CRDT- 2011/02/26 06:00
PHST- 2011/02/26 06:00 [entrez]
PHST- 2011/02/26 06:00 [pubmed]
PHST- 2011/08/13 06:00 [medline]
AID - 10.1089/sur.2010.046 [doi]
PST - ppublish
SO  - Surg Infect (Larchmt). 2011 Apr;12(2):127-30. doi: 10.1089/sur.2010.046. Epub
      2011 Feb 24.


PMID- 21348548
OWN - NLM
STAT- MEDLINE
DCOM- 20110617
LR  - 20141212
IS  - 1944-706X (Electronic)
IS  - 1083-4087 (Linking)
VI  - 17
IP  - 2
DP  - 2011 Mar
TI  - What do we really know about VBID? Quality of the evidence and ethical
      considerations for health plan sponsors.
PG  - 156-74
FAU - Fairman, Kathleen A
AU  - Fairman KA
FAU - Curtiss, Frederic R
AU  - Curtiss FR
LA  - eng
PT  - Comment
PT  - Editorial
PL  - United States
TA  - J Manag Care Pharm
JT  - Journal of managed care pharmacy : JMCP
JID - 9605854
SB  - IM
CON - J Manag Care Pharm. 2010 Mar;16(2):130-3. PMID: 20178398
CON - J Manag Care Pharm. 2011 Mar;17(2):143-55. PMID: 21348547
MH  - Health Care Reform/*economics
MH  - Health Policy/*economics
MH  - Health Services/economics
MH  - Humans
MH  - Insurance, Health/economics/ethics/*organization & administration
MH  - Research/standards
MH  - *Research Design
MH  - United States
MH  - United States Agency for Healthcare Research and Quality
EDAT- 2011/02/26 06:00
MHDA- 2011/06/18 06:00
CRDT- 2011/02/26 06:00
PHST- 2011/02/26 06:00 [entrez]
PHST- 2011/02/26 06:00 [pubmed]
PHST- 2011/06/18 06:00 [medline]
AID - 2011(17)2: 156-174 [pii]
AID - 10.18553/jmcp.2011.17.2.156 [doi]
PST - ppublish
SO  - J Manag Care Pharm. 2011 Mar;17(2):156-74. doi: 10.18553/jmcp.2011.17.2.156.


PMID- 21321345
OWN - NLM
STAT- MEDLINE
DCOM- 20110311
LR  - 20110215
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Linking)
VI  - 76
IP  - 7 Suppl 2
DP  - 2011 Feb 15
TI  - Amyotrophic lateral sclerosis: ethical challenges.
PG  - S1-5
LID - 10.1212/WNL.0b013e31820d57ee [doi]
FAU - Johnston, Wendy S
AU  - Johnston WS
AD  - Department of Medicine (Neurology), University of Alberta, Edmonton, Alberta,
      Canada. wendy.johnston@ualberta.ca
FAU - Hoskins, Katelin
AU  - Hoskins K
FAU - McCluskey, Leo
AU  - McCluskey L
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
SB  - IM
MH  - Amyotrophic Lateral Sclerosis/*psychology/*therapy
MH  - *Ethicists
MH  - Humans
EDAT- 2011/02/26 06:00
MHDA- 2011/03/12 06:00
CRDT- 2011/02/16 06:00
PHST- 2011/02/16 06:00 [entrez]
PHST- 2011/02/26 06:00 [pubmed]
PHST- 2011/03/12 06:00 [medline]
AID - 76/7_Supplement_2/S1 [pii]
AID - 10.1212/WNL.0b013e31820d57ee [doi]
PST - ppublish
SO  - Neurology. 2011 Feb 15;76(7 Suppl 2):S1-5. doi: 10.1212/WNL.0b013e31820d57ee.


PMID- 21347934
OWN - NLM
STAT- MEDLINE
DCOM- 20120327
LR  - 20211020
IS  - 1744-1706 (Electronic)
IS  - 1744-1692 (Linking)
VI  - 7
IP  - 1
DP  - 2012
TI  - British American Tobacco's partnership with Earthwatch Europe and its
      implications for public health.
PG  - 14-28
LID - 10.1080/17441692.2010.549832 [doi]
AB  - This paper explores a partnership between British American Tobacco (BAT) and the 
      environmental organisation Earthwatch Europe (EE) and considers its implications 
      for countries implementing Article 5.3 of the World Health Organization Framework
      Convention on Tobacco Control. We reviewed approximately 100 internal BAT
      documents, interviewed EE's former executive director and examined media accounts
      and BAT and EE websites. We analysed materials by reviewing them iteratively,
      identifying themes, constructing a timeline of events and assembling a case
      study. BAT sought a partnership with EE to gain a global ally that could provide 
      entree into the larger non-governmental organisation (NGO) community. EE debated 
      the ethics of working with BAT, resolving them in BAT's favour and taking a
      narrow view of its own overall organisational mission. To protect its reputation,
      EE delayed public disclosure of the partnership. Instead, EE promoted it to
      policy-makers and other NGOs, extending BAT's reputation and reach into
      influential circles. The potential for normalising the tobacco industry presence 
      within government through NGO partnerships and the benefits that accrued to BAT
      even when the partnership was not being publicised show why governments seeking
      to protect effective tobacco control policies from industry influence need to
      consider ways to identify and discourage 'hidden' NGO partnerships.
FAU - McDaniel, Patricia A
AU  - McDaniel PA
AD  - Department of Social and Behavioral Sciences, University of California, San
      Francisco, 3333 California Street, Suite 455, San Francisco, CA 94118, USA.
      patricia.mcdaniel@ucsf.edu
FAU - Malone, Ruth E
AU  - Malone RE
LA  - eng
GR  - R01 CA120138/CA/NCI NIH HHS/United States
GR  - R01 CA120138-05/CA/NCI NIH HHS/United States
GR  - 1R01 CA120138/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20110524
PL  - England
TA  - Glob Public Health
JT  - Global public health
JID - 101256323
SB  - IM
MH  - Environmental Health/*ethics/organization & administration
MH  - Ethics, Business
MH  - Europe
MH  - Humans
MH  - Interinstitutional Relations
MH  - Organizations/ethics
MH  - Smoking/adverse effects
MH  - *Smoking Prevention
MH  - *Social Responsibility
MH  - Tobacco Industry/*ethics/organization & administration
MH  - United Kingdom
MH  - United States
MH  - World Health Organization
PMC - PMC3134627
MID - NIHMS263345
EDAT- 2011/02/25 06:00
MHDA- 2012/03/28 06:00
CRDT- 2011/02/25 06:00
PHST- 2011/02/25 06:00 [entrez]
PHST- 2011/02/25 06:00 [pubmed]
PHST- 2012/03/28 06:00 [medline]
AID - 933891939 [pii]
AID - 10.1080/17441692.2010.549832 [doi]
PST - ppublish
SO  - Glob Public Health. 2012;7(1):14-28. doi: 10.1080/17441692.2010.549832. Epub 2011
      May 24.


PMID- 21347737
OWN - NLM
STAT- MEDLINE
DCOM- 20110804
LR  - 20110419
IS  - 1496-8975 (Electronic)
IS  - 0832-610X (Linking)
VI  - 58
IP  - 5
DP  - 2011 May
TI  - Perioperative myocardial ischemia and isolated systolic hypertension in
      non-cardiac surgery.
PG  - 428-35
LID - 10.1007/s12630-011-9477-7 [doi]
AB  - PURPOSE: To determine whether patients with isolated systolic hypertension (ISH) 
      undergoing non-cardiac surgery have a higher incidence of perioperative
      myocardial ischemia than normotensive patients and hence a greater risk for
      perioperative adverse events. METHODS: After obtaining Research Ethics Board
      approval, patients were recruited to either an ISH group (systolic blood pressure
      [SBP] > 140 mmHg with diastolic blood pressure [DBP] < 90 mmHg) or a normotensive
      group (SBP < 140 mmHg and DBP < 90 mmHg), according to their resting preoperative
      blood pressure. The primary outcome was the overall incidence of perioperative
      myocardial ischemia (PMI) as determined by 48-hr ambulatory Holter monitoring. P 
      values </= 0.05 were considered to be statistically significant. RESULTS: A total
      of 312 (150 ISH and 162 normotensive) patients completed the study. Orthopedic
      surgery was the most frequent surgical procedure in both groups. The overall
      incidence of PMI was 19.7% in the ISH group compared with 18.8% in the
      normotensive group (difference 0.9%; 95% confidence interval [CI], -7.9% to
      9.8%). The overall incidence of adverse events was 4.0% in the ISH group compared
      with 1.9% in the normotensive group (difference 2.2%; 95% CI, -1.6% to 5.9%).
      CONCLUSION: In this study, we chose to examine ISH as potential cardiac risk
      factor for patients undergoing non-cardiac surgery. The incidence of myocardial
      ischemia, a surrogate outcome, was similar in the two groups. The relatively high
      incidence of myocardial ischemia (19.2%) was of particular interest in this
      relatively low cardiac risk surgical population. (ClinicalTrials.gov number,
      NCT01237652).
FAU - Fayad, Ashraf A
AU  - Fayad AA
AD  - Department of Anesthesiology, University of Ottawa, 1053 Carling Ave (B3),
      Ottawa, ON K1Y 4E9, Canada. afayad@ottawahospital.on.ca
FAU - Yang, Homer Y
AU  - Yang HY
FAU - Ruddy, Terrence D
AU  - Ruddy TD
FAU - Watters, James M
AU  - Watters JM
FAU - Wells, George A
AU  - Wells GA
LA  - eng
SI  - ClinicalTrials.gov/NCT01237652
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110224
PL  - United States
TA  - Can J Anaesth
JT  - Canadian journal of anaesthesia = Journal canadien d'anesthesie
JID - 8701709
SB  - IM
MH  - Aged
MH  - Blood Pressure
MH  - Case-Control Studies
MH  - Electrocardiography, Ambulatory
MH  - Female
MH  - Humans
MH  - Hypertension/*complications
MH  - Incidence
MH  - Intraoperative Complications/*epidemiology/etiology
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/*epidemiology/etiology
MH  - Postoperative Complications/*epidemiology/etiology
MH  - Prospective Studies
MH  - Risk Factors
MH  - Surgical Procedures, Operative/adverse effects/methods
EDAT- 2011/02/25 06:00
MHDA- 2011/08/05 06:00
CRDT- 2011/02/25 06:00
PHST- 2010/08/24 00:00 [received]
PHST- 2011/02/14 00:00 [accepted]
PHST- 2011/02/25 06:00 [entrez]
PHST- 2011/02/25 06:00 [pubmed]
PHST- 2011/08/05 06:00 [medline]
AID - 10.1007/s12630-011-9477-7 [doi]
PST - ppublish
SO  - Can J Anaesth. 2011 May;58(5):428-35. doi: 10.1007/s12630-011-9477-7. Epub 2011
      Feb 24.


PMID- 21347576
OWN - NLM
STAT- MEDLINE
DCOM- 20120315
LR  - 20191210
IS  - 0942-0940 (Electronic)
IS  - 0001-6268 (Linking)
VI  - 153
IP  - 5
DP  - 2011 May
TI  - Surgical intervention for severe head injury: ethical considerations when
      performing life-saving but non-restorative surgery.
PG  - 1105-10
LID - 10.1007/s00701-011-0974-9 [doi]
AB  - BACKGROUND: The aim of this study was to compare the predicted outcome with
      observed outcome in those patients who have had a unilateral decompressive
      craniectomy following evacuation of an intracranial mass lesion and to consider
      some of the ethical issues that need to be addressed when performing life-saving 
      but non-restorative surgery. METHODS: By using the web-based outcome prediction
      model developed by the CRASH trial collaborators predicted and observed outcomes 
      were compared for those patients who had had a unilateral decompression after
      evacuation of a mass lesion in the two major neurotrauma hospitals in Western
      Australia between 2004 and 2008. Three cases were selected with differing outcome
      predictions. RESULTS: For the three selected cases the predicted risk of an
      unfavourable outcome at 6 months was 65.8%, 78.9% and 91.3%, respectively. For
      the 11 patients in this cohort with an outcome prediction between 61% and 70%,
      the observed outcome at 18 months (GOS) was: 5 had a good outcome, 4 were
      moderately disabled, and 3 were severely disabled. For the ten patients with an
      outcome prediction between 90-100%, observed outcome confirmed: one patient was
      moderately disabled, four patients were severely disabled, one patient was in a
      permanent vegetative state, and four patients had died. CONCLUSION: As the index 
      of injury severity (as adjudged by the CRASH outcome prediction model) increases,
      clinical decision making and discussion with surrogates must reflect the evidence
      provided by observed outcome, prior to life-saving but potentially
      non-restorative decompressive surgery.
FAU - Honeybul, Stephen
AU  - Honeybul S
AD  - Department of Neurosurgery, Sir Charles Gairdner Hospital and Royal Perth
      Hospital, Perth, Western Australia, Australia. stephen.honeybul@health.wa.gov.au
FAU - Ho, Kwok M
AU  - Ho KM
FAU - Lind, Christopher R P
AU  - Lind CR
FAU - Gillett, Grant R
AU  - Gillett GR
LA  - eng
PT  - Case Reports
PT  - Comparative Study
PT  - Journal Article
DEP - 20110224
PL  - Austria
TA  - Acta Neurochir (Wien)
JT  - Acta neurochirurgica
JID - 0151000
SB  - IM
MH  - Adult
MH  - Brain Injuries/diagnosis/mortality/surgery
MH  - Cohort Studies
MH  - Craniocerebral Trauma/diagnosis/*mortality/*surgery
MH  - Decompressive Craniectomy/*ethics/*mortality
MH  - Humans
MH  - Middle Aged
MH  - Outcome Assessment, Health Care/methods
MH  - Prognosis
MH  - Severity of Illness Index
EDAT- 2011/02/25 06:00
MHDA- 2012/03/16 06:00
CRDT- 2011/02/25 06:00
PHST- 2010/11/23 00:00 [received]
PHST- 2011/02/10 00:00 [accepted]
PHST- 2011/02/25 06:00 [entrez]
PHST- 2011/02/25 06:00 [pubmed]
PHST- 2012/03/16 06:00 [medline]
AID - 10.1007/s00701-011-0974-9 [doi]
PST - ppublish
SO  - Acta Neurochir (Wien). 2011 May;153(5):1105-10. doi: 10.1007/s00701-011-0974-9.
      Epub 2011 Feb 24.


PMID- 21346757
OWN - NLM
STAT- MEDLINE
DCOM- 20110511
LR  - 20110322
IS  - 1532-6535 (Electronic)
IS  - 0009-9236 (Linking)
VI  - 89
IP  - 4
DP  - 2011 Apr
TI  - Challenges in obtaining adequate genetic sample sets in clinical trials: the
      perspective of the industry pharmacogenomics working group.
PG  - 529-36
LID - 10.1038/clpt.2010.305 [doi]
AB  - Collection of DNA samples from subjects participating in clinical trials is vital
      to understanding variability in drug response. The purpose of this study was to
      assess pharmacogenetic sample-collection practices in the industry and to gather 
      information on issues affecting collection. A survey questionnaire was developed 
      and distributed to 20 pharmaceutical companies; 15 provided responses.
      Assessments included rate of DNA sample collection, reasons for low collection
      rates, reasons for rejection by health authorities (HAs) and institutional review
      boards/ethics committees (IRBs/ECs), and country-specific hurdles to sample
      collection. The results indicated that, although DNA samples are frequently
      collected, sample-acquisition rates remain lower than expected. Overall, the
      companies' experience has been that restrictions on sample usage are not
      consistently applied by regulatory bodies. This may reflect changing
      opinions/interpretations of HAs/IRBs/ECs. Collection of DNA samples in industry
      trials is still a challenge. Harmonization of sample-collection practices may
      facilitate the process.
FAU - Warner, A W
AU  - Warner AW
AD  - Clinical Pharmacogenomics and Clinical Specimen Management, Merck & Co., Inc.,
      North Wales, Pennsylvania, USA. amelia.warner@merck.com
FAU - Bhathena, A
AU  - Bhathena A
FAU - Gilardi, S
AU  - Gilardi S
FAU - Mohr, D
AU  - Mohr D
FAU - Leong, D
AU  - Leong D
FAU - Bienfait, K L
AU  - Bienfait KL
FAU - Sarang, J
AU  - Sarang J
FAU - Duprey, S
AU  - Duprey S
FAU - Franc, M A
AU  - Franc MA
FAU - Nelsen, A
AU  - Nelsen A
FAU - Snapir, A
AU  - Snapir A
LA  - eng
PT  - Journal Article
DEP - 20110223
PL  - United States
TA  - Clin Pharmacol Ther
JT  - Clinical pharmacology and therapeutics
JID - 0372741
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Clinical Trials as Topic/*methods
MH  - DNA/*analysis
MH  - Data Collection
MH  - Drug Industry/*statistics & numerical data
MH  - Humans
MH  - Pharmacogenetics/*methods
MH  - Specimen Handling/methods
EDAT- 2011/02/25 06:00
MHDA- 2011/05/12 06:00
CRDT- 2011/02/25 06:00
PHST- 2011/02/25 06:00 [entrez]
PHST- 2011/02/25 06:00 [pubmed]
PHST- 2011/05/12 06:00 [medline]
AID - clpt2010305 [pii]
AID - 10.1038/clpt.2010.305 [doi]
PST - ppublish
SO  - Clin Pharmacol Ther. 2011 Apr;89(4):529-36. doi: 10.1038/clpt.2010.305. Epub 2011
      Feb 23.


PMID- 21346753
OWN - NLM
STAT- MEDLINE
DCOM- 20110511
LR  - 20110322
IS  - 1532-6535 (Electronic)
IS  - 0009-9236 (Linking)
VI  - 89
IP  - 4
DP  - 2011 Apr
TI  - Global requirements for DNA sample collections: results of a survey of 204 ethics
      committees in 40 countries.
PG  - 554-61
LID - 10.1038/clpt.2010.319 [doi]
AB  - The Industry Pharmacogenomics Working Group has an interest in attaining a better
      understanding of global requirements for sample collections intended for
      pharmacogenetics research. To have adequately powered pharmacogenetics studies
      representative of the clinical trial population, it is important to collect DNA
      samples from a majority of consenting study participants under many institutional
      review board/ethics committee (IRB/EC) jurisdictions. A survey was distributed to
      gather information from local and central IRBs/ECs. The survey included questions
      related to the approval of pharmacogenetics studies, collection and banking of
      samples, and return of data to subjects. A total of 204 responses were received
      from global IRBs/ECs with pharmacogenetic experience. The data show that
      requirements for approval of pharmacogenetic research differ between IRBs/ECs
      within and between countries but not between regions of the United States. A
      better understanding of differing requirements should facilitate global sample
      collection of DNA for pharmacogenetics research and may provide the basis for
      harmonized regulations for collection of genetic samples in the future.
FAU - Ricci, D S
AU  - Ricci DS
AD  - Johnson & Johnson Pharmaceutical Research and Development, Raritan, New Jersey,
      USA. dricci@its.jnj.com
FAU - Broderick, E D
AU  - Broderick ED
FAU - Tchelet, A
AU  - Tchelet A
FAU - Hong, F
AU  - Hong F
FAU - Mayevsky, S
AU  - Mayevsky S
FAU - Mohr, D M
AU  - Mohr DM
FAU - Schaffer, M E
AU  - Schaffer ME
FAU - Warner, A W
AU  - Warner AW
FAU - Hakkulinen, P
AU  - Hakkulinen P
FAU - Snapir, A
AU  - Snapir A
LA  - eng
PT  - Journal Article
DEP - 20110223
PL  - United States
TA  - Clin Pharmacol Ther
JT  - Clinical pharmacology and therapeutics
JID - 0372741
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Clinical Trials as Topic/methods
MH  - DNA/*analysis
MH  - Data Collection
MH  - Drug Design
MH  - Ethics Committees, Research/*statistics & numerical data
MH  - Humans
MH  - Pharmacogenetics/*methods
MH  - Specimen Handling/methods
EDAT- 2011/02/25 06:00
MHDA- 2011/05/12 06:00
CRDT- 2011/02/25 06:00
PHST- 2011/02/25 06:00 [entrez]
PHST- 2011/02/25 06:00 [pubmed]
PHST- 2011/05/12 06:00 [medline]
AID - clpt2010319 [pii]
AID - 10.1038/clpt.2010.319 [doi]
PST - ppublish
SO  - Clin Pharmacol Ther. 2011 Apr;89(4):554-61. doi: 10.1038/clpt.2010.319. Epub 2011
      Feb 23.


PMID- 21346752
OWN - NLM
STAT- MEDLINE
DCOM- 20110511
LR  - 20110322
IS  - 1532-6535 (Electronic)
IS  - 0009-9236 (Linking)
VI  - 89
IP  - 4
DP  - 2011 Apr
TI  - Coding of DNA samples and data in the pharmaceutical industry: current practices 
      and future directions--perspective of the I-PWG.
PG  - 537-45
LID - 10.1038/clpt.2010.306 [doi]
AB  - DNA samples collected in clinical trials and stored for future research are
      valuable to pharmaceutical drug development. Given the perceived higher risk
      associated with genetic research, industry has implemented complex coding methods
      for DNA. Following years of experience with these methods and with addressing
      questions from institutional review boards (IRBs), ethics committees (ECs) and
      health authorities, the industry has started reexamining the extent of the added 
      value offered by these methods. With the goal of harmonization, the Industry
      Pharmacogenomics Working Group (I-PWG) conducted a survey to gain an
      understanding of company practices for DNA coding and to solicit opinions on
      their effectiveness at protecting privacy. The results of the survey and the
      limitations of the coding methods are described. The I-PWG recommends dialogue
      with key stakeholders regarding coding practices such that equal standards are
      applied to DNA and non-DNA samples. The I-PWG believes that industry standards
      for privacy protection should provide adequate safeguards for DNA and non-DNA
      samples/data and suggests a need for more universal standards for samples stored 
      for future research.
FAU - Franc, M A
AU  - Franc MA
AD  - Department of Pharmacogenomics, Johnson & Johnson Pharmaceutical Research and
      Development, Raritan, New Jersey, USA. mfranc@its.jnj.com
FAU - Cohen, N
AU  - Cohen N
FAU - Warner, A W
AU  - Warner AW
FAU - Shaw, P M
AU  - Shaw PM
FAU - Groenen, P
AU  - Groenen P
FAU - Snapir, A
AU  - Snapir A
CN  - Industry Pharmacogenomics Working Group
LA  - eng
PT  - Journal Article
DEP - 20110223
PL  - United States
TA  - Clin Pharmacol Ther
JT  - Clinical pharmacology and therapeutics
JID - 0372741
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Clinical Coding/methods
MH  - Clinical Trials as Topic/*methods
MH  - DNA/*analysis
MH  - Data Collection
MH  - Drug Design
MH  - Drug Industry/*methods
MH  - Humans
MH  - Pharmacogenetics/*methods
MH  - Privacy
MH  - Specimen Handling/methods/standards
EDAT- 2011/02/25 06:00
MHDA- 2011/05/12 06:00
CRDT- 2011/02/25 06:00
PHST- 2011/02/25 06:00 [entrez]
PHST- 2011/02/25 06:00 [pubmed]
PHST- 2011/05/12 06:00 [medline]
AID - clpt2010306 [pii]
AID - 10.1038/clpt.2010.306 [doi]
PST - ppublish
SO  - Clin Pharmacol Ther. 2011 Apr;89(4):537-45. doi: 10.1038/clpt.2010.306. Epub 2011
      Feb 23.


PMID- 21346627
OWN - NLM
STAT- MEDLINE
DCOM- 20120305
LR  - 20211020
IS  - 1708-8267 (Electronic)
IS  - 1081-5589 (Linking)
VI  - 59
IP  - 5
DP  - 2011 Jun
TI  - Ethics and technology transfer: patients, patents, and public trust.
PG  - 762-7
LID - 10.2310/JIM.0b013e318210eeb0 [doi]
AB  - Universities and academic medical centers have been increasing their focus on
      technology transfer and research commercialization. With this shift in focus,
      academic-industry ties have become prevalent. These relationships can benefit
      academic researchers and help then to transform their research into tangible
      societal benefits. However, there also are concerns that these ties and the
      greater academic focus on commercialization might lead to conflicts of interest, 
      especially financial conflicts of interest. This paper briefly explores some of
      these conflicts of interest, particularly relating to research and training. This
      paper also discusses some of the policies that have been, and are being,
      developed to try to mitigate and manage these conflicts so that academic
      involvement in technology transfer and commercialization can continue without
      jeopardizing academic work or the public's trust in them.
FAU - Zucker, Deborah
AU  - Zucker D
AD  - Tufts University School of Medicine, Boston, MA 02111, USA.
      dzucker@post.harvard.edu
LA  - eng
GR  - R01 EB002009/EB/NIBIB NIH HHS/United States
GR  - R13 RR023236/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - J Investig Med
JT  - Journal of investigative medicine : the official publication of the American
      Federation for Clinical Research
JID - 9501229
SB  - IM
MH  - Biomedical Research/ethics/trends
MH  - Conflict of Interest
MH  - Disclosure/ethics
MH  - Humans
MH  - Industry/ethics
MH  - Patents as Topic/*ethics
MH  - Public Opinion
MH  - Research Support as Topic/*ethics
MH  - *Technology Transfer
MH  - Trust
MH  - Universities
PMC - PMC3703588
MID - NIHMS274776
EDAT- 2011/02/25 06:00
MHDA- 2012/03/06 06:00
CRDT- 2011/02/25 06:00
PHST- 2011/02/25 06:00 [entrez]
PHST- 2011/02/25 06:00 [pubmed]
PHST- 2012/03/06 06:00 [medline]
AID - 10.2310/JIM.0b013e318210eeb0 [doi]
PST - ppublish
SO  - J Investig Med. 2011 Jun;59(5):762-7. doi: 10.2310/JIM.0b013e318210eeb0.


PMID- 21345861
OWN - NLM
STAT- MEDLINE
DCOM- 20120103
LR  - 20161125
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 7
DP  - 2011 Jul
TI  - Emergency research in children: options for ethical recruitment.
PG  - 429-32
LID - 10.1136/jme.2010.040667 [doi]
AB  - The paucity of research data to guide current paediatric practice has led to
      children being termed therapeutic orphans. This difficulty is especially
      pertinent to research in emergency situations, such as acute resuscitation or
      critical care, where accepted ethical standards for overall research, have
      historically created practical difficulties for researchers. The welcome
      establishment of organisations to support UK paediatric research is helping to
      ensure safer and more effective medications for children, however as the balance 
      between protection and access at the heart of the paediatric research ethical
      debate shifts to ever increasing access for researchers to children, it remains
      crucial to ensure the protection for these vulnerable participants. The
      fundamental protection for research subjects, namely their full informed consent 
      before any recruitment, is not tenable in true emergency situations and so other 
      approaches are warranted if standards are to be improved by human subjects
      research in such areas. Proxy, deferred and retrospective consent have all been
      advocated as solutions to this difficulty and this paper explores the ethical
      justification for these approaches and their utility in safeguarding children and
      families in emergency situations when traditional informed consent, as currently 
      defined, cannot be obtained in the necessary time frame to enable research.
FAU - Brierley, Joe
AU  - Brierley J
AD  - Paediatric and Neonatal Intensive Care Unit, Great Ormond Street Hospital for
      Children NHS Trust, Great Ormond St, London, UK. brierj@gosh.nhs.uk
FAU - Larcher, Vic
AU  - Larcher V
LA  - eng
PT  - Journal Article
DEP - 20110223
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Child
MH  - Child, Preschool
MH  - Clinical Trials as Topic/*ethics
MH  - Emergencies
MH  - Emergency Medicine/*ethics
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Informed Consent/*ethics
MH  - *Research Subjects
MH  - United Kingdom
EDAT- 2011/02/25 06:00
MHDA- 2012/01/04 06:00
CRDT- 2011/02/25 06:00
PHST- 2011/02/25 06:00 [entrez]
PHST- 2011/02/25 06:00 [pubmed]
PHST- 2012/01/04 06:00 [medline]
AID - jme.2010.040667 [pii]
AID - 10.1136/jme.2010.040667 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Jul;37(7):429-32. doi: 10.1136/jme.2010.040667. Epub 2011 Feb 
      23.


PMID- 21345860
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20110421
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 5
DP  - 2011 May
TI  - Disclosure of individual research results in clinico-genomic trials: challenges, 
      classification and criteria for decision-making.
PG  - 271-5
LID - 10.1136/jme.2009.034041 [doi]
AB  - While an ethical obligation to report findings of clinical research to trial
      participants is increasingly recognised, the academic debate is often vague about
      what kinds of data should be fed back and how such a process should be organised.
      In this article, we present a classification of different actors, processes and
      data involved in the feedback of research results pertaining to an individual. In
      a second step, we reflect on circumstances requiring further ethical
      consideration. In regard to a concrete research setting--the one of
      clinico-genomic research--we discuss what kinds of difficulties have to be faced 
      when returning individual research results to trial participants. In a last step,
      we elaborate on a stepwise model to trigger the individual feedback process.
      Hence, this paper gives guidance on how to feedback individual research results
      in a specific research setting and responds at the same time to new challenges in
      the debate on the duty to return individual research findings.
FAU - Kollek, Regine
AU  - Kollek R
AD  - University of Hamburg, Research Centre for Biotechnology, Society and the
      Environment, Research Group on Medicine and Neuroscience, Lottestrasse 55,
      D-22529 Hamburg, Germany.
FAU - Petersen, Imme
AU  - Petersen I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110223
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Clinical Trials as Topic/*ethics
MH  - Decision Making/*ethics
MH  - Disclosure/*ethics
MH  - Female
MH  - Genetic Research/*ethics
MH  - Humans
MH  - Informed Consent/*ethics/psychology
MH  - Male
MH  - Research
MH  - Research Design
EDAT- 2011/02/25 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/02/25 06:00
PHST- 2011/02/25 06:00 [entrez]
PHST- 2011/02/25 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - jme.2009.034041 [pii]
AID - 10.1136/jme.2009.034041 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 May;37(5):271-5. doi: 10.1136/jme.2009.034041. Epub 2011 Feb
      23.


PMID- 21345573
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20110425
IS  - 1873-1570 (Electronic)
IS  - 0300-9572 (Linking)
VI  - 82
IP  - 5
DP  - 2011 May
TI  - Point prevalence of patients fulfilling MET criteria in ten MET equipped
      hospitals. The methodology of the RESCUE study.
PG  - 529-34
LID - 10.1016/j.resuscitation.2011.01.012 [doi]
AB  - OBJECTIVE: The RESCUE study examined the prevalence of patients at risk of a
      medical emergency in acute care settings by assessing the prevalence of cases
      where patients fulfil the hospital-specific criteria for MET activation. This
      article will detail the study methodology including the ethics applications and
      approvals process, organisational preparation, research staff training, tools for
      data collection, as well as barriers encountered during the conduct of the study.
      DESIGN AND SETTING: A point prevalence design conducted at 10 hospitals,
      comprising of private and public, secondary and tertiary referral, ICU equipped, 
      metropolitan and regional settings. PATIENTS: All inpatients were eligible except
      intensive care and psychiatric patients. MEASUREMENT AND MAIN RESULTS: On a
      single day consenting inpatients in each hospital had a single set of vital signs
      obtained, their observation chart reviewed and followed up for MET activations,
      unplanned ICU admissions, cardiac arrests and 30 and 60 day mortality. Of 2199
      eligible patients, 1688 (76.76%) were assessed, 175 (7.95%) refused consent and
      336 (15.28%) were unavailable. Access to patients was refused in some wards
      despite ethics approval. Data collection required 2 student nurses approximately 
      14 min per patient assessment. CONCLUSION: In conducting a large multi-site point
      prevalence study, critical organisational processes were shown to influence the
      access to patients. This study demonstrated the impact of variation in Human
      Research Ethics Committee interpretations of protocols on consenting processes
      and the importance of communication and leadership at ward level to promote
      access to patients.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Bucknall, Tracey K
AU  - Bucknall TK
AD  - Cabrini Health, Australia. tracey.bucknall@deakin.edu.au
FAU - Jones, Daryl
AU  - Jones D
FAU - Barrett, Jonathon
AU  - Barrett J
FAU - Bellomo, Rinaldo
AU  - Bellomo R
FAU - Botti, Mari
AU  - Botti M
FAU - Considine, Julie
AU  - Considine J
FAU - Currey, Judy
AU  - Currey J
FAU - Dunning, Trisha L
AU  - Dunning TL
FAU - Green, David
AU  - Green D
FAU - Levinson, Michele
AU  - Levinson M
FAU - Livingston, Patricia M
AU  - Livingston PM
FAU - O'Connell, Bev
AU  - O'Connell B
FAU - Ruseckaite, Rasa
AU  - Ruseckaite R
FAU - Staples, Margaret
AU  - Staples M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20110222
PL  - Ireland
TA  - Resuscitation
JT  - Resuscitation
JID - 0332173
SB  - IM
MH  - Critical Care/*organization & administration
MH  - Critical Illness/*mortality
MH  - Emergency Service, Hospital/*organization & administration
MH  - Hospital Mortality/trends
MH  - *Hospitals, University
MH  - Humans
MH  - Intensive Care Units/organization & administration
MH  - Patient Care Team/*organization & administration
MH  - Prospective Studies
MH  - Victoria
MH  - Workload/*statistics & numerical data
EDAT- 2011/02/25 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/02/25 06:00
PHST- 2010/11/04 00:00 [received]
PHST- 2010/12/21 00:00 [revised]
PHST- 2011/01/10 00:00 [accepted]
PHST- 2011/02/25 06:00 [entrez]
PHST- 2011/02/25 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - S0300-9572(11)00059-1 [pii]
AID - 10.1016/j.resuscitation.2011.01.012 [doi]
PST - ppublish
SO  - Resuscitation. 2011 May;82(5):529-34. doi: 10.1016/j.resuscitation.2011.01.012.
      Epub 2011 Feb 22.


PMID- 21345555
OWN - NLM
STAT- MEDLINE
DCOM- 20130321
LR  - 20220310
IS  - 1532-3099 (Electronic)
IS  - 0266-6138 (Linking)
VI  - 28
IP  - 2
DP  - 2012 Apr
TI  - Using diaries to explore midwives' experiences in intrapartum care: an evaluation
      of the method in a phenomenological study.
PG  - 150-5
LID - 10.1016/j.midw.2010.12.007 [doi]
AB  - AIM: finding appropriate ways of obtaining contemporaneous data in acute settings
      is an ethical and practical dilemma for researchers. Our aim was to evaluate the 
      use of diaries by midwives in a research study informed by a phenomenological
      approach. SETTING AND SAMPLE: a purposive sample of 12 midwives working across
      three Trusts in the North West of England. METHOD: a phenomenological approach
      was used to guide a study exploring midwives views of confidence when providing
      intrapartum care. Two methods of data collection were used; diaries and
      semi-structured interviews. This is a methodological paper reporting on the
      usefulness of diaries used with participants who were health professionals in a
      health-care setting. RESULTS: participants completing qualitative diaries
      provided rich data, recording not only a description of events but also their
      emotional response to such events. A high degree of self-reflection and analysis 
      was also evident. The participants provided contextual and time situated data
      although remaining focused on the phenomena being explored. Furthermore, the
      diaries highlighted the data that may not have been uncovered by interview alone.
      CONCLUSION: use of diaries for qualitative data collection is feasible and well
      received by health professionals. Individuals completing diaries were engaged in 
      a reflective process enabling them to address significant events. Hence, diaries 
      may provide benefits to both the researcher and the participant. They proved
      appropriate to a study requiring an exploration of the lived experience of the
      participants. Researchers conducting research informed by a phenomenological
      perspective should consider diaries as a valuable data collection tool.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Bedwell, Carol
AU  - Bedwell C
AD  - School of Nursing, Midwifery and Social Work, University of Manchester, Oxford
      Road, Manchester, United Kingdom. carol.bedwell@manchester.ac.uk
FAU - McGowan, Linda
AU  - McGowan L
FAU - Lavender, Tina
AU  - Lavender T
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20110222
PL  - Scotland
TA  - Midwifery
JT  - Midwifery
JID - 8510930
MH  - *Attitude of Health Personnel
MH  - Delivery of Health Care
MH  - England
MH  - Female
MH  - Humans
MH  - Midwifery/*methods
MH  - Nursing Methodology Research
MH  - *Nursing Records
MH  - Perinatal Care/*methods
MH  - Pregnancy
MH  - Qualitative Research
EDAT- 2011/02/25 06:00
MHDA- 2013/03/22 06:00
CRDT- 2011/02/25 06:00
PHST- 2010/08/23 00:00 [received]
PHST- 2010/12/03 00:00 [revised]
PHST- 2010/12/22 00:00 [accepted]
PHST- 2011/02/25 06:00 [entrez]
PHST- 2011/02/25 06:00 [pubmed]
PHST- 2013/03/22 06:00 [medline]
AID - S0266-6138(10)00205-6 [pii]
AID - 10.1016/j.midw.2010.12.007 [doi]
PST - ppublish
SO  - Midwifery. 2012 Apr;28(2):150-5. doi: 10.1016/j.midw.2010.12.007. Epub 2011 Feb
      22.


PMID- 21345295
OWN - NLM
STAT- MEDLINE
DCOM- 20110503
LR  - 20181201
IS  - 0392-856X (Print)
IS  - 0392-856X (Linking)
VI  - 29
IP  - 1
DP  - 2011 Jan-Feb
TI  - Identification and quantification of selected inflammatory genes modulated by
      leflunomide and prednisone treatment in early rheumatoid arthritis patients.
PG  - 72-9
AB  - OBJECTIVES: The present study evaluates the effects of combined leflunomide (LEF)
      and low dose of prednisone therapy, on selected inflammatory gene expression in
      peripheral blood mononuclear cells (PBMCs) of early rheumatoid arthritis (ERA)
      patients by gene microarray analysis and quantitative real time-polymerase chain 
      reaction (qRT-PCR). METHODS: Ten ERA patients (mean age 53 +/- 10 years) were
      assigned as untreated (group 1) or pre-treated (group 2) with prednisone (5
      mg/day for 3 months) after informed consent and ethics committee approval. Five
      sex- and age-matched healthy subjects were used as controls (CNT). RNA was
      extracted by PBMCs, amplified, labelled and hybridised on inflammation DualChip
      microarray. The expression ratio of 282 inflammatory genes between CNT and ERA
      patients, before (T0) and after 12 weeks (T1) of combined therapy was detected.
      qRT-PCR was performed on 7 selected inflammatory RA-related genes (STAT4, MAPK9, 
      HIF1A, MIF, STAT6, NFKB1, TNFRSF1B). RESULTS: At T0, microarray analysis showed
      34 altered genes in both ERA groups when compared to CNT (vs. CNT). Seven
      RA-related genes, investigated in further details, were found up-regulated in
      group 1 and down-regulated or unchanged in group 2 vs. CNT. At T1, combined
      therapy induced the down-regulation of these genes in both groups vs. CNT as also
      confirmed by qRT-PCR performed on selected genes. CONCLUSIONS: Untreated ERA
      patients seem characterised by up-regulation of specific genes involved both in
      the resistance/inhibition to apoptosis and in the stimulation of pro-inflammatory
      cytokine production by immune inflammatory cells. Combined LEF and low dose of
      prednisone therapy seems to play synergistic effects on down-regulation of these 
      genes.
FAU - Cutolo, Maurizio
AU  - Cutolo M
AD  - Department of Internal Medicine, University of Genova, Genova, Italy.
      mcutolo@unige.it
FAU - Villaggio, Barbara
AU  - Villaggio B
FAU - Brizzolara, Renata
AU  - Brizzolara R
FAU - Montagna, Paola
AU  - Montagna P
FAU - Gallo, Fabio
AU  - Gallo F
FAU - Moretti, Stefano
AU  - Moretti S
FAU - Bonassi, Stefano
AU  - Bonassi S
FAU - Sulli, Alberto
AU  - Sulli A
FAU - Soldano, Stefano
AU  - Soldano S
LA  - eng
PT  - Journal Article
DEP - 20110223
PL  - Italy
TA  - Clin Exp Rheumatol
JT  - Clinical and experimental rheumatology
JID - 8308521
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Cytokines)
RN  - 0 (Glucocorticoids)
RN  - 0 (Isoxazoles)
RN  - 0 (RNA, Messenger)
RN  - 0 (Transcription Factors)
RN  - G162GK9U4W (Leflunomide)
RN  - VB0R961HZT (Prednisone)
SB  - IM
MH  - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use
MH  - Apoptosis/drug effects/genetics
MH  - Arthritis, Rheumatoid/*drug therapy/genetics
MH  - Cytokines/metabolism
MH  - Drug Synergism
MH  - Drug Therapy, Combination
MH  - Female
MH  - Gene Expression Profiling
MH  - Glucocorticoids/*therapeutic use
MH  - Humans
MH  - Isoxazoles/*therapeutic use
MH  - Leflunomide
MH  - Male
MH  - Microarray Analysis
MH  - Middle Aged
MH  - Prednisone/*therapeutic use
MH  - RNA, Messenger
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Synovitis/drug therapy/genetics
MH  - Transcription Factors/*genetics
MH  - Up-Regulation
EDAT- 2011/02/25 06:00
MHDA- 2011/05/04 06:00
CRDT- 2011/02/25 06:00
PHST- 2010/08/05 00:00 [received]
PHST- 2010/12/15 00:00 [accepted]
PHST- 2011/02/25 06:00 [entrez]
PHST- 2011/02/25 06:00 [pubmed]
PHST- 2011/05/04 06:00 [medline]
AID - 4207 [pii]
PST - ppublish
SO  - Clin Exp Rheumatol. 2011 Jan-Feb;29(1):72-9. Epub 2011 Feb 23.


PMID- 21345280
OWN - NLM
STAT- MEDLINE
DCOM- 20120816
LR  - 20211020
IS  - 1466-609X (Electronic)
IS  - 1364-8535 (Linking)
VI  - 15
IP  - 1
DP  - 2011 Jan 24
TI  - Organ donation and the ethics of muddling through.
PG  - 109
LID - 10.1186/cc9379 [doi]
AB  - Organ donation offers opportunities for people in critical care units to help
      save the lives of other patients. It is not always easy, however, to handle the
      transition from treating a patient to preserving a potential donor, and organ
      donation consistently provokes ethical questions in critical care units. What do 
      we expect ethics to deliver? In light of a recent ethics conference in Denmark,
      we suggest that by acknowledging that decisions made in the clinic rarely abide
      to rational decision trees with clear ethical priorities, we can better learn
      from each other's experiences. We suggest embracing an 'ethics of muddling
      through' to enhance relevant reflections and stimulate a productive dialogue
      among health professionals.
CI  - (c) 2011 BioMed Central Ltd
FAU - Hoeyer, Klaus
AU  - Hoeyer K
AD  - Department of Public Health, Faculty of Health Sciences, University of
      Copenhagen, CSS, Ouster Farimagsgade 5, Room 10.0.09, DK-1014 Copenhagen,
      Denmark. klho@sund.ku.dk
FAU - Jensen, Anja M B
AU  - Jensen AM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110124
PL  - England
TA  - Crit Care
JT  - Critical care (London, England)
JID - 9801902
SB  - IM
MH  - *Attitude to Death
MH  - Decision Making/ethics
MH  - Ethics, Medical
MH  - Humans
MH  - Tissue Donors/*ethics
MH  - Tissue and Organ Procurement/*ethics
PMC - PMC3222022
EDAT- 2011/02/25 06:00
MHDA- 2012/08/17 06:00
CRDT- 2011/02/25 06:00
PHST- 2011/02/25 06:00 [entrez]
PHST- 2011/02/25 06:00 [pubmed]
PHST- 2012/08/17 06:00 [medline]
AID - cc9379 [pii]
AID - 10.1186/cc9379 [doi]
PST - epublish
SO  - Crit Care. 2011 Jan 24;15(1):109. doi: 10.1186/cc9379.


PMID- 21345226
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20211020
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 12
DP  - 2011 Feb 23
TI  - Double-blinded, randomized controlled trial comparing real versus placebo
      acupuncture to improve tolerance of diagnostic esophagogastroduodenoscopy without
      sedation: a study protocol.
PG  - 52
LID - 10.1186/1745-6215-12-52 [doi]
AB  - BACKGROUND: Sedation prior to performance of diagnostic
      esophagogastroduodenoscopy (EGDE) is widespread and increases patient comfort.
      But 98% of all serious adverse events during EGDEs are ascribed to sedation. The 
      S3 guideline for sedation procedures in gastrointestinal endoscopy published in
      2008 in Germany increases patient safety by standardization. These new
      regulations increase costs because of the need for more personnel and a prolonged
      discharge procedure after examinations with sedation. Many patients have
      difficulties to meet the discharge criteria regulated by the S3 guideline, e.g.
      the call for a second person to escort them home, to resign from driving and
      working for the rest of the day, resulting in a refusal of sedation. Therefore,
      we would like to examine if an acupuncture during elective, diagnostic EGDEs
      could increase the comfort of patients refusing systemic sedation.
      METHODS/DESIGN: A single-center, double blinded, placebo controlled superiority
      trial to compare the success rates of elective, diagnostic EGDEs with real and
      placebo acupuncture. All patients aged 18 years or older scheduled for elective, 
      diagnostic EGDE who refuse a systemic sedation are eligible. 354 patients will be
      randomized. The primary endpoint is the rate of successful EGDEs with the
      randomized technique. INTERVENTION: Real or placebo acupuncture before and during
      EGDE. Duration of study: Approximately 24 months. DISCUSSION:
      Organisation/Responsibility The ACUPEND--Trial will be conducted in accordance
      with the protocol and in compliance with the moral, ethical, and scientific
      principles governing clinical research as set out in the Declaration of Helsinki 
      (1989) and Good Clinical Practice (GCP). The Interdisciplinary Endoscopy Center
      (IEZ) of the University Hospital Heidelberg is responsible for design and conduct
      of the trial, including randomization and documentation of patients' data. Data
      management and statistical analysis will be performed by the independent
      Institute for Medical Biometry and Informatics (IMBI) and the Center of Clinical 
      Trials (KSC) at the Department of General, Visceral and Transplantation Surgery, 
      University of Heidelberg. TRIAL REGISTRATION: The trial is registered at
      Germanctr.de (DRKS00000164) on December 10th 2009. The first patient was
      randomized on February 2nd 2010.
FAU - Knebel, P
AU  - Knebel P
AD  - Department of General, Visceral and Transplantation Surgery, University of
      Heidelberg, Germany. phillip.knebel@med.uni-heidelberg.de
FAU - Schwan, K
AU  - Schwan K
FAU - Bruckner, T
AU  - Bruckner T
FAU - Seiler, Cm
AU  - Seiler C
FAU - Plaschke, K
AU  - Plaschke K
FAU - Streitberger, K
AU  - Streitberger K
FAU - Schaible, A
AU  - Schaible A
FAU - Bopp, C
AU  - Bopp C
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20110223
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
SB  - IM
MH  - *Acupuncture Therapy/adverse effects
MH  - Double-Blind Method
MH  - *Endoscopy, Digestive System/adverse effects
MH  - Germany
MH  - Humans
MH  - Patient Satisfaction
MH  - Predictive Value of Tests
MH  - *Research Design
MH  - Treatment Outcome
PMC - PMC3055829
EDAT- 2011/02/25 06:00
MHDA- 2011/06/29 06:00
CRDT- 2011/02/25 06:00
PHST- 2010/08/10 00:00 [received]
PHST- 2011/02/23 00:00 [accepted]
PHST- 2011/02/25 06:00 [entrez]
PHST- 2011/02/25 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
AID - 1745-6215-12-52 [pii]
AID - 10.1186/1745-6215-12-52 [doi]
PST - epublish
SO  - Trials. 2011 Feb 23;12:52. doi: 10.1186/1745-6215-12-52.


PMID- 21345195
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20211020
IS  - 1824-7288 (Electronic)
IS  - 1720-8424 (Linking)
VI  - 37
DP  - 2011 Feb 23
TI  - Framework conditions facilitating paediatric clinical research.
PG  - 12
LID - 10.1186/1824-7288-37-12 [doi]
AB  - The use of unlicensed and "off-label" medicines in children is widespread.
      Between 50-80% of the medicines currently administered to children have neither
      been tested nor authorized for their use in the paediatric population which
      represents approximately 25% of the whole European population. On 26 January
      2007, entered into force the European Regulation of Paediatric Medicines. It aims
      at the quality of research into medicines for children but without subjecting the
      paediatric population to unnecessary clinical trial. This article addresses
      ethical and legal issues arising from the regulation and makes recommendations
      for the framework conditions facilitating the development of clinical research
      with children.
FAU - Knellwolf, Anne-Laure
AU  - Knellwolf AL
AD  - Dept, of Therapeutic Research and Medicines Evaluation, Istituto Superiore di
      Sanita, Rome, Italy. anne.knellwolf@iss.it
FAU - Bauzon, Stephane
AU  - Bauzon S
FAU - Alberighi, Ornella Della Casa
AU  - Alberighi OD
FAU - Lutsar, Irja
AU  - Lutsar I
FAU - Bacsy, Erno
AU  - Bacsy E
FAU - Alfarez, Deborah
AU  - Alfarez D
FAU - Panei, Pietro
AU  - Panei P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110223
PL  - England
TA  - Ital J Pediatr
JT  - Italian journal of pediatrics
JID - 101510759
SB  - IM
MH  - Biomedical Research/*ethics/*legislation & jurisprudence
MH  - Child
MH  - Clinical Trials as Topic/*ethics/*legislation & jurisprudence
MH  - Europe
MH  - Humans
MH  - Pediatrics/*ethics/*legislation & jurisprudence
PMC - PMC3055809
EDAT- 2011/02/25 06:00
MHDA- 2011/07/27 06:00
CRDT- 2011/02/25 06:00
PHST- 2011/02/07 00:00 [received]
PHST- 2011/02/23 00:00 [accepted]
PHST- 2011/02/25 06:00 [entrez]
PHST- 2011/02/25 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
AID - 1824-7288-37-12 [pii]
AID - 10.1186/1824-7288-37-12 [doi]
PST - epublish
SO  - Ital J Pediatr. 2011 Feb 23;37:12. doi: 10.1186/1824-7288-37-12.


PMID- 21345175
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111123
LR  - 20211020
IS  - 1758-9193 (Electronic)
VI  - 3
IP  - 1
DP  - 2011 Feb 8
TI  - Should EOAD patients be included in clinical trials?
PG  - 4
LID - 10.1186/alzrt63 [doi]
AB  - Alzheimer disease (AD) is a devastating neurodegenerative disease affecting 1 in 
      68 in the population. An arbitrary cutoff 65 years as the age of onset to
      distinguish between early- and late-onset AD has been proposed and has been used 
      in the literature for decades. As the majority of patients develop AD after 65
      years of age, most clinical trials address this population. While the early-onset
      cases represent only 1% to 6% of AD cases, this population is the active working 
      subset and thus contributes to a higher public health burden per individual, and 
      early-onset cases are the most devastating at the level of the individual and
      their families. In this review, we compare and contrast the clinical,
      neuropsychological, imaging, genetic, biomarker, and pathological features of
      these two arbitrary groups. Finally, we discuss the ethical dilemma of
      non-abandonment and justice as it pertains to exclusion of the early-onset AD
      patients from clinical trials.
FAU - Szigeti, Kinga
AU  - Szigeti K
AD  - Department of Neurology and Alzheimer's Disease and Memory Disorders Center,
      Baylor College of Medicine, 7200B Cambridge Street, Suite E5,101, Houston, TX
      77030, USA. rdoody@bcm.edu.
FAU - Doody, Rachelle S
AU  - Doody RS
LA  - eng
PT  - Journal Article
DEP - 20110208
PL  - England
TA  - Alzheimers Res Ther
JT  - Alzheimer's research & therapy
JID - 101511643
PMC - PMC3109413
EDAT- 2011/02/25 06:00
MHDA- 2011/02/25 06:01
CRDT- 2011/02/25 06:00
PHST- 2011/02/25 06:00 [entrez]
PHST- 2011/02/25 06:00 [pubmed]
PHST- 2011/02/25 06:01 [medline]
AID - alzrt63 [pii]
AID - 10.1186/alzrt63 [doi]
PST - epublish
SO  - Alzheimers Res Ther. 2011 Feb 8;3(1):4. doi: 10.1186/alzrt63.


PMID- 21345062
OWN - NLM
STAT- MEDLINE
DCOM- 20110609
LR  - 20121115
IS  - 1466-187X (Electronic)
IS  - 0142-159X (Linking)
VI  - 33
IP  - 3
DP  - 2011
TI  - Research in assessment: consensus statement and recommendations from the Ottawa
      2010 Conference.
PG  - 224-33
LID - 10.3109/0142159X.2011.551558 [doi]
AB  - Medical education research in general is a young scientific discipline which is
      still finding its own position in the scientific range. It is rooted in both the 
      biomedical sciences and the social sciences, each with their own scientific
      language. A more unique feature of medical education (and assessment) research is
      that it has to be both locally and internationally relevant. This is not always
      easy and sometimes leads to purely ideographic descriptions of an assessment
      procedure with insufficient general lessons or generalised scientific knowledge
      being generated or vice versa. For medical educational research, a plethora of
      methodologies is available to cater to many different research questions. This
      article contains consensus positions and suggestions on various elements of
      medical education (assessment) research. Overarching is the position that without
      a good theoretical underpinning and good knowledge of the existing literature,
      good research and sound conclusions are impossible to produce, and that there is 
      no inherently superior methodology, but that the best methodology is the one most
      suited to answer the research question unambiguously. Although the positions
      should not be perceived as dogmas, they should be taken as very serious
      recommendations. Topics covered are: types of research, theoretical frameworks,
      designs and methodologies, instrument properties or psychometrics,
      costs/acceptability, ethics, infrastructure and support.
FAU - Schuwirth, Lambert
AU  - Schuwirth L
AD  - Educational Development and Research, Maastricht University, PO Box 616,
      Maastricht, 6200 MD, The Netherlands. l.schuwirth@maastrichtuniversity.nl
FAU - Colliver, Jerry
AU  - Colliver J
FAU - Gruppen, Larry
AU  - Gruppen L
FAU - Kreiter, Clarence
AU  - Kreiter C
FAU - Mennin, Stewart
AU  - Mennin S
FAU - Onishi, Hirotaka
AU  - Onishi H
FAU - Pangaro, Louis
AU  - Pangaro L
FAU - Ringsted, Charlotte
AU  - Ringsted C
FAU - Swanson, David
AU  - Swanson D
FAU - Van Der Vleuten, Cees
AU  - Van Der Vleuten C
FAU - Wagner-Menghin, Michaela
AU  - Wagner-Menghin M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Med Teach
JT  - Medical teacher
JID - 7909593
SB  - IM
MH  - Consensus Development Conferences as Topic
MH  - *Education, Medical
MH  - Educational Measurement/*methods
MH  - Ethics, Research
MH  - Humans
MH  - Probability Theory
MH  - Reproducibility of Results
MH  - Research/*organization & administration
MH  - *Research Design
EDAT- 2011/02/25 06:00
MHDA- 2011/06/10 06:00
CRDT- 2011/02/25 06:00
PHST- 2011/02/25 06:00 [entrez]
PHST- 2011/02/25 06:00 [pubmed]
PHST- 2011/06/10 06:00 [medline]
AID - 10.3109/0142159X.2011.551558 [doi]
PST - ppublish
SO  - Med Teach. 2011;33(3):224-33. doi: 10.3109/0142159X.2011.551558.


PMID- 21344823
OWN - NLM
STAT- MEDLINE
DCOM- 20110315
LR  - 20110224
IS  - 1077-3525 (Print)
IS  - 1077-3525 (Linking)
VI  - 17
IP  - 1
DP  - 2011 Jan-Mar
TI  - Human rights and health: opportunities to advance rural occupational health.
PG  - 80-92
AB  - Human rights norms principally apply to governments, setting out state
      obligations and citizen entitlements to a range of social and material claims,
      whereas the highest ethical standards of occupational health professionals (OHPs)
      are outlined in ethical codes. Human rights discourse is rarely used to shape
      professional standards for health and safety. Yet there is much potential for
      synergy by applying human rights approaches to workplace health and safety and
      professional ethics. A review of international treaties confirms an extensive
      articulation of the right to workplace health and safety. A case study of
      pesticide exposure risks to small farmers in developing countries illustrates the
      links between human rights, occupational health practice, and professional
      ethics. OHPs have a responsibility to assist in the realization of workers'
      occupational health rights, particularly by promoting meaningful participation of
      those affected by hazardous exposures. Human rights approaches may assist the
      prevention of work-related morbidity.
FAU - London, Leslie
AU  - London L
AD  - School of Public Health and Family Medicine, University of Cape Town, Anzia Road,
      Observatory, Cape Town 7925, South Africa. leslie.london@uct.ac.za
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Occup Environ Health
JT  - International journal of occupational and environmental health
JID - 9505217
RN  - 0 (Pesticides)
SB  - IM
MH  - Agricultural Workers' Diseases/*prevention & control
MH  - *Human Rights
MH  - Humans
MH  - International Cooperation
MH  - Occupational Exposure/*ethics
MH  - *Occupational Health
MH  - Pesticides/toxicity
MH  - *Rural Health
EDAT- 2011/02/25 06:00
MHDA- 2011/03/16 06:00
CRDT- 2011/02/25 06:00
PHST- 2011/02/25 06:00 [entrez]
PHST- 2011/02/25 06:00 [pubmed]
PHST- 2011/03/16 06:00 [medline]
AID - 10.1179/107735211799031103 [doi]
PST - ppublish
SO  - Int J Occup Environ Health. 2011 Jan-Mar;17(1):80-92. doi:
      10.1179/107735211799031103.


PMID- 21344041
OWN - NLM
STAT- MEDLINE
DCOM- 20110713
LR  - 20211020
IS  - 1550-9397 (Electronic)
IS  - 1550-9389 (Linking)
VI  - 7
IP  - 1
DP  - 2011 Feb 15
TI  - Ethical issues in the conduct of clinical trials in obstructive sleep apnea.
PG  - 103-8
AB  - Scientifically rigorous clinical trials are needed to test continuous positive
      airway pressure's (CPAP) effect on important clinical endpoints known to be
      associated with obstructive sleep apnea, such as myocardial infarction, cardiac
      arrhythmias, stroke, mortality, seizures, and cognitive function. In this
      "Special Article," we review the regulatory and ethical issues that surround the 
      design and conduct of CPAP trials, including selection of the appropriate control
      condition, exclusion criteria, and follow-up duration.
FAU - Brown, Devin L
AU  - Brown DL
AD  - Stroke Program, University of Michigan, Ann Arbor, MI 48109-5855, USA.
      devinb@umich.edu
FAU - Anderson, Craig S
AU  - Anderson CS
FAU - Chervin, Ronald D
AU  - Chervin RD
FAU - Kushida, Clete A
AU  - Kushida CA
FAU - Lewin, Daniel S
AU  - Lewin DS
FAU - Malow, Beth A
AU  - Malow BA
FAU - Redline, Susan
AU  - Redline S
FAU - Goldman, Edward B
AU  - Goldman EB
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Clin Sleep Med
JT  - Journal of clinical sleep medicine : JCSM : official publication of the American 
      Academy of Sleep Medicine
JID - 101231977
SB  - IM
MH  - *Comorbidity
MH  - Continuous Positive Airway Pressure/adverse effects/*ethics/methods
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Informed Consent/ethics
MH  - Male
MH  - Patient Selection
MH  - Randomized Controlled Trials as Topic/*ethics
MH  - Risk Assessment
MH  - Sleep Apnea, Obstructive/diagnosis/*therapy
MH  - Total Quality Management
MH  - United States
PMC - PMC3041615
OTO - NOTNLM
OT  - Obstructive sleep apnea
OT  - clinical trials
OT  - ethics
EDAT- 2011/02/24 06:00
MHDA- 2011/07/14 06:00
CRDT- 2011/02/24 06:00
PHST- 2011/02/24 06:00 [entrez]
PHST- 2011/02/24 06:00 [pubmed]
PHST- 2011/07/14 06:00 [medline]
PST - ppublish
SO  - J Clin Sleep Med. 2011 Feb 15;7(1):103-8.


PMID- 21343794
OWN - NLM
STAT- MEDLINE
DCOM- 20110412
LR  - 20210107
IS  - 1873-233X (Electronic)
IS  - 0029-7844 (Linking)
VI  - 117
IP  - 3
DP  - 2011 Mar
TI  - Committee Opinion No. 480: Empathy in women's health care.
PG  - 756-761
LID - 10.1097/AOG.0b013e3182147865 [doi]
AB  - Empathy is the process through which one attempts to project oneself into
      another's life and imagine a situation from his or her point of view. Most
      individuals do have an innate capacity to show empathy toward others. Empathy is 
      as important to being a good physician as technical competence. However, at times
      the health care environment and educational process overly emphasize
      technological competence, curing disease rather than healing the patient, or the 
      economic aspects of medicine. This may interfere with an empathic approach in the
      clinical setting. In this Committee Opinion, the Committee on Ethics of the
      American College of Obstetricians and Gynecologists defines empathy and related
      terms, describes the role of empathy in medicine, outlines objections and
      barriers to incorporating empathy into clinical care, reviews research on
      measuring empathy, discusses the inclusion of empathy in medical education, and
      makes recommendations about empathic care for health care providers and the
      health care system.
LA  - eng
PT  - Journal Article
PT  - Practice Guideline
PL  - United States
TA  - Obstet Gynecol
JT  - Obstetrics and gynecology
JID - 0401101
SB  - IM
MH  - Clinical Competence
MH  - Education, Medical
MH  - *Empathy
MH  - Female
MH  - Gynecology/standards
MH  - Humans
MH  - Obstetrics/standards
MH  - Patient Care
MH  - Physician-Patient Relations
MH  - *Women's Health
EDAT- 2011/02/24 06:00
MHDA- 2011/04/13 06:00
CRDT- 2011/02/24 06:00
PHST- 2011/02/24 06:00 [entrez]
PHST- 2011/02/24 06:00 [pubmed]
PHST- 2011/04/13 06:00 [medline]
AID - 10.1097/AOG.0b013e3182147865 [doi]
AID - 00006250-201103000-00045 [pii]
PST - ppublish
SO  - Obstet Gynecol. 2011 Mar;117(3):756-761. doi: 10.1097/AOG.0b013e3182147865.


PMID- 21343743
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20110223
IS  - 1539-073X (Electronic)
IS  - 1520-9229 (Linking)
VI  - 13
IP  - 1
DP  - 2011 Jan-Mar
TI  - Nurse drug diversion and nursing leader's responsibilities: legal, regulatory,
      ethical, humanistic, and practical considerations.
PG  - 13-6
LID - 10.1097/NHL.0b013e31820bd9e6 [doi]
AB  - Nurses who divert drugs pose significant threats to patient safety, but also
      become a liability to healthcare organizations and the nursing department where
      the diversion occurred. Healthcare and nursing leaders have a responsibility to
      ensure that security systems are in place to prevent diversion and protect
      patients if nursing impairment is suspected as a result of drug diversion.
      Nursing leaders must consider legal, regulatory, ethical, humanistic, and
      practical considerations in resolving this issue.
FAU - Tanga, Hazel Y
AU  - Tanga HY
AD  - Department of Veterans Affairs Hospital of San Diego, California, USA.
      hazel.tanga@va.gov
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - JONAS Healthc Law Ethics Regul
JT  - JONA'S healthcare law, ethics and regulation
JID - 100888423
MH  - Drug and Narcotic Control/*legislation & jurisprudence/*methods
MH  - Ethics, Nursing
MH  - Humans
MH  - *Leadership
MH  - Legislation, Nursing
MH  - *Medication Systems, Hospital
MH  - *Nurse Administrators
MH  - Professional Impairment
MH  - Security Measures
MH  - *Social Responsibility
MH  - Substance-Related Disorders/diagnosis/rehabilitation
MH  - Theft/*ethics/*legislation & jurisprudence
EDAT- 2011/02/24 06:00
MHDA- 2011/07/27 06:00
CRDT- 2011/02/24 06:00
PHST- 2011/02/24 06:00 [entrez]
PHST- 2011/02/24 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
AID - 10.1097/NHL.0b013e31820bd9e6 [doi]
AID - 00128488-201101000-00003 [pii]
PST - ppublish
SO  - JONAS Healthc Law Ethics Regul. 2011 Jan-Mar;13(1):13-6. doi:
      10.1097/NHL.0b013e31820bd9e6.


PMID- 21343629
OWN - NLM
STAT- MEDLINE
DCOM- 20120103
LR  - 20110620
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 7
DP  - 2011 Jul
TI  - Quality of ethical guidelines and ethical content in clinical guidelines: the
      example of end-of-life decision-making.
PG  - 390-6
LID - 10.1136/jme.2010.040121 [doi]
AB  - BACKGROUND: While there are many guidelines on how to make ethical decisions at
      the end of life, there is little evidence regarding the quality of this sort of
      ethical guidelines. OBJECTIVES: First, this study aims to demonstrate the
      conceptual transferability of the Appraisal of Guidelines for Research and
      Evaluation (AGREE) instrument for the quality assessment of ethical guidelines.
      Second, it aims to illustrate the status quo of the quality of guidelines on
      end-of-life decision-making by using the AGREE instrument in a first practice
      test. METHOD: The transferability of the AGREE instrument on the quality
      assessment of ethical guidelines is demonstrated by conceptual analysis.
      Guidelines on end-of-life decisions in medicine are identified through a
      systematic search in MEDLINE (from June 1999 to June 2009). The quality of all
      included guidelines was assessed with a slightly modified AGREE instrument.
      RESULTS: Of 103 guidelines identified, 34 were included as relevant. The majority
      of the guidelines analysed in this study were assessed as qualitatively
      insufficient in five out of six AGREE quality domains. A few guidelines
      demonstrated, however, that a high level of quality in accordance with the AGREE 
      requirements is possible. CONCLUSION: This review concludes that the quality of
      many ethical guidelines should and can be improved in all quality domains
      specified by the AGREE instrument. Furthermore, conceptual analysis indicates
      that a slightly modified AGREE instrument is transferable to the comprehensive
      evaluation of the quality of ethical guidelines. Nevertheless, future research is
      needed to improve the assessment of the presentation of the guidelines' normative
      basis.
FAU - Strech, Daniel
AU  - Strech D
AD  - Centre for Ethics and Law in the Life Sciences (CELLS), Institut fur Geschichte, 
      Ethik und Philosophie der Medizin, Medizinische Hochschule Hannover, Carl-Neuberg
      Strasse 1, Hannover, Germany. strech.daniel@mh-hannover.de
FAU - Schildmann, Jan
AU  - Schildmann J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110222
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Advance Directives/ethics
MH  - Decision Making/*ethics
MH  - Humans
MH  - *Practice Guidelines as Topic
MH  - Terminal Care/*ethics
EDAT- 2011/02/24 06:00
MHDA- 2012/01/04 06:00
CRDT- 2011/02/24 06:00
PHST- 2011/02/24 06:00 [entrez]
PHST- 2011/02/24 06:00 [pubmed]
PHST- 2012/01/04 06:00 [medline]
AID - jme.2010.040121 [pii]
AID - 10.1136/jme.2010.040121 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Jul;37(7):390-6. doi: 10.1136/jme.2010.040121. Epub 2011 Feb
      22.


PMID- 21342593
OWN - NLM
STAT- MEDLINE
DCOM- 20110909
LR  - 20110223
IS  - 1876-8784 (Electronic)
IS  - 0028-2162 (Linking)
VI  - 155
DP  - 2011
TI  - [Patient safety in clinical intervention research].
PG  - A2359
AB  - In clinical intervention research, the monitoring of patient safety is essential.
      In December 2009, a symposium on the role of the different parties involved was
      organised. Research starts with a robust protocol with a section dealing with
      interim decision-making and procedures for reporting during the research. After
      the approval by an accredited Ethics Committee, the responsibility for the
      patient safety primarily lies with the investigators and sponsor (in the case of 
      investigator-initiated research generally the Institutional Board of Directors). 
      In addition, the appointment of a Data and Safety Monitoring Committee (DSMC) has
      become more frequent during recent years. This committee monitors the safety of
      patients by means of evaluation of interim results and advises the sponsor
      accordingly. The decision process concerning premature ending is a clinical
      decision, which should not exclusively be based on exceeding a statistical limit.
      The focus of the DSMC should be on safety issues; only in exceptional cases
      should a trial be discontinued because of clear efficacy, or the lack of it.
FAU - Brekelmans, Cecile T M
AU  - Brekelmans CT
AD  - Centrale Commissie voor Mensgebonden Onderzoek, Den Haag, The Netherlands.
      c.brekelmans@ccmo.nl
FAU - Kenter, Marcel J H
AU  - Kenter MJ
FAU - Bouter, Lex M
AU  - Bouter LM
FAU - Koeter, Gerard H
AU  - Koeter GH
LA  - dut
PT  - English Abstract
PT  - Journal Article
TT  - Patientveiligheid bij klinisch interventieonderzoek.
PL  - Netherlands
TA  - Ned Tijdschr Geneeskd
JT  - Nederlands tijdschrift voor geneeskunde
JID - 0400770
SB  - IM
MH  - Clinical Trials as Topic/*standards
MH  - *Decision Making
MH  - *Ethics Committees, Research
MH  - Humans
MH  - Research Design
MH  - Safety
EDAT- 2011/02/24 06:00
MHDA- 2011/09/10 06:00
CRDT- 2011/02/24 06:00
PHST- 2011/02/24 06:00 [entrez]
PHST- 2011/02/24 06:00 [pubmed]
PHST- 2011/09/10 06:00 [medline]
PST - ppublish
SO  - Ned Tijdschr Geneeskd. 2011;155:A2359.


PMID- 21342444
OWN - NLM
STAT- MEDLINE
DCOM- 20110609
LR  - 20110727
IS  - 1600-6143 (Electronic)
IS  - 1600-6135 (Linking)
VI  - 11
IP  - 3
DP  - 2011 Mar
TI  - The use of executed prisoners as a source of organ transplants in China must
      stop.
PG  - 426-8
LID - 10.1111/j.1600-6143.2010.03417.x [doi]
AB  - Internationally accepted ethical standards are unequivocal in their prohibition
      of the use of organs recovered from executed prisoners: yet this practice
      continues in China despite indications that Ministry of Health officials intend
      to end this abhorrent practice. Recently published articles on this topic
      emphasize the medical complications that result from liver transplantation from
      executed 'donors' but scant attention is given to the source of the organs,
      raising concern that the transplant community may be becoming inured to
      unacceptable practice. Strategies to influence positive change in organ donation 
      practice in China by the international transplant community are discussed. They
      include an absolutist policy whereby no clinical data from China is deemed
      acceptable until unacceptable donation practices end, and an incremental policy
      whereby clinical data is carefully evaluated for acceptability. The relative
      advantages and drawbacks of these strategies are discussed together with some
      practical suggestions for response available to individuals and the transplant
      community.
CI  - (c)2011 The Authors Journal compilation(c)2011 The American Society of
      Transplantation and the American Society of Transplant Surgeons.
FAU - Danovitch, G M
AU  - Danovitch GM
AD  - David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
FAU - Shapiro, M E
AU  - Shapiro ME
FAU - Lavee, J
AU  - Lavee J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
SB  - IM
CIN - Am J Transplant. 2011 Jun;11(6):1341; author reply 1342. PMID: 21564532
MH  - China
MH  - Humans
MH  - Living Donors/*statistics & numerical data
MH  - Organ Transplantation/*ethics
MH  - Prisoners/*legislation & jurisprudence
MH  - Tissue and Organ Procurement/*ethics
EDAT- 2011/02/24 06:00
MHDA- 2011/06/10 06:00
CRDT- 2011/02/24 06:00
PHST- 2011/02/24 06:00 [entrez]
PHST- 2011/02/24 06:00 [pubmed]
PHST- 2011/06/10 06:00 [medline]
AID - 10.1111/j.1600-6143.2010.03417.x [doi]
PST - ppublish
SO  - Am J Transplant. 2011 Mar;11(3):426-8. doi: 10.1111/j.1600-6143.2010.03417.x.


PMID- 21342420
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20191210
IS  - 1547-5069 (Electronic)
IS  - 1527-6546 (Linking)
VI  - 43
IP  - 1
DP  - 2011 Mar
TI  - Early indicators and risk factors for ethical issues in clinical practice.
PG  - 13-21
LID - 10.1111/j.1547-5069.2010.01380.x [doi]
AB  - PURPOSE: Nurses in all clinical settings encounter ethical issues that frequently
      lead to moral distress. This critical incident study explored nurses'
      descriptions of ethically difficult situations to identify risk factors and early
      indicators of ethical conflicts. METHODS: Employing the critical incident
      technique, researchers developed a questionnaire that collected information on
      ethically difficult situations, their risk factors and early indicators, nurse
      actions, and situational outcomes. Two nurse researchers independently analyzed
      and categorized data using a constant comparison technique. FINDINGS: Most of the
      ethically difficult situations pertained to end-of-life care for children and
      adults. Conflicts in interpersonal relationships were prevalent. Nurses were
      especially moved by patient and family suffering and concerned about patient
      vulnerability, harm-benefit ratio, and patient autonomy. Researchers discovered
      risk factor categories for patients, families, healthcare providers, and health
      systems. Additionally, researchers found subcategories in six major categories of
      early indicators: signs of conflict, patient suffering, nurse distress, ethics
      violation, unrealistic expectations, and poor communication. CONCLUSIONS: Nurses 
      are keenly aware of pertinent risk factors and early indicators of unfolding
      ethical conflicts. Many nurses reported feeling powerless in the face of ethical 
      conflict. Research that develops interventions to strengthen nurses' voices in
      ethically difficult situation is warranted. CLINICAL RELEVANCE: Nurses are in a
      key position to identify patient situations with a high risk for ethical
      conflict. Initiating early ethics consultation and interventions can alter the
      course of pending conflicts and diminish the potential for patient and family
      suffering and nurses' moral distress.
CI  - (c) 2011 Sigma Theta Tau International.
FAU - Pavlish, Carol
AU  - Pavlish C
AD  - UCLA School of Nursing, Los Angeles, CA, USA. cpavlish@sonnet.ucla.edu
FAU - Brown-Saltzman, Katherine
AU  - Brown-Saltzman K
FAU - Hersh, Mary
AU  - Hersh M
FAU - Shirk, Marilyn
AU  - Shirk M
FAU - Nudelman, Olga
AU  - Nudelman O
LA  - eng
PT  - Journal Article
DEP - 20110114
PL  - United States
TA  - J Nurs Scholarsh
JT  - Journal of nursing scholarship : an official publication of Sigma Theta Tau
      International Honor Society of Nursing
JID - 100911591
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Attitude to Death
MH  - Communication
MH  - *Conflict, Psychological
MH  - Decision Making
MH  - *Ethics, Nursing
MH  - Female
MH  - Humans
MH  - Male
MH  - Morals
MH  - Risk Factors
MH  - Surveys and Questionnaires
MH  - Task Performance and Analysis
MH  - Terminal Care/psychology
EDAT- 2011/02/24 06:00
MHDA- 2011/07/27 06:00
CRDT- 2011/02/24 06:00
PHST- 2011/02/24 06:00 [entrez]
PHST- 2011/02/24 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
AID - 10.1111/j.1547-5069.2010.01380.x [doi]
PST - ppublish
SO  - J Nurs Scholarsh. 2011 Mar;43(1):13-21. doi: 10.1111/j.1547-5069.2010.01380.x.
      Epub 2011 Jan 14.


PMID- 21342068
OWN - NLM
STAT- MEDLINE
DCOM- 20110617
LR  - 20110223
IS  - 1744-8336 (Electronic)
IS  - 1478-7210 (Linking)
VI  - 9
IP  - 2
DP  - 2011 Feb
TI  - HIV testing strategies: test performance is important, but not sufficient.
PG  - 207-14
LID - 10.1586/eri.10.165 [doi]
AB  - Minimum accuracy of HIV diagnostic tests is considered the pillar on which
      testing strategies for all settings must be based. Systematic reviews and
      meta-analyses have shown that performance of the same test in different settings 
      may vary according to several factors, resulting in different confidence
      intervals for sensitivity and specificity. Prevalence of HIV infection may
      influence observed test accuracy. The purpose of this article is to use the
      knowledge from meta-analyses of general diagnostic tests to inform the specific
      field of HIV diagnostic strategies. We propose the 'Bayesian' thinking:
      considering the pretest probability (i.e., prevalence, risk factors) and
      understanding test limitations to estimate a post-test probability of HIV
      diagnosis. Cost-effectiveness analysis, patient preferences and ethical issues
      must also be considered in HIV testing strategies.
FAU - Cota, Glaucia Fernandes
AU  - Cota GF
AD  - Hospital das Clinicas, Federal University of Minas Gerais, Brazil.
FAU - de Abreu Ferrari, Teresa Cristina
AU  - de Abreu Ferrari TC
FAU - de Sousa, Marcos Roberto
AU  - de Sousa MR
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Expert Rev Anti Infect Ther
JT  - Expert review of anti-infective therapy
JID - 101181284
SB  - IM
MH  - AIDS Serodiagnosis/economics/*methods/*standards
MH  - Algorithms
MH  - Bayes Theorem
MH  - Cost-Benefit Analysis
MH  - HIV Infections/*diagnosis/epidemiology
MH  - Humans
MH  - Male
MH  - Meta-Analysis as Topic
MH  - Predictive Value of Tests
MH  - Prevalence
MH  - Risk Factors
MH  - Sensitivity and Specificity
EDAT- 2011/02/24 06:00
MHDA- 2011/06/18 06:00
CRDT- 2011/02/24 06:00
PHST- 2011/02/24 06:00 [entrez]
PHST- 2011/02/24 06:00 [pubmed]
PHST- 2011/06/18 06:00 [medline]
AID - 10.1586/eri.10.165 [doi]
PST - ppublish
SO  - Expert Rev Anti Infect Ther. 2011 Feb;9(2):207-14. doi: 10.1586/eri.10.165.


PMID- 21340565
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20211020
IS  - 1432-1955 (Electronic)
IS  - 0932-0113 (Linking)
VI  - 109
IP  - 3
DP  - 2011 Sep
TI  - Opisthorchis viverrini infection causes liver and biliary cirrhosis in gerbils.
PG  - 545-51
LID - 10.1007/s00436-011-2282-y [doi]
AB  - Opisthorchis viverrini infection causes many hepatobiliary diseases, including
      cholangiocarcinoma. Hence, the study of O. viverrini infection in humans is
      subject to ethical limitations, so an animal model, the Syrian hamster, is often 
      used. O. viverrini can develop into the adult stage not only in Syrian hamsters
      but also in other animals, including gerbils, but until now, there has been no
      report on pathology and susceptibility in gerbils. The present study revealed the
      pathology of O. viverrini infection in gerbils through gross appearance,
      histopathology, and worm recovery at various time points. Gerbils were infected
      with 50 O. viverrini metacercariae and then sacrificed at the time of
      observation. The gross appearance of the liver showed micronodules at the liver
      surface, suggesting liver and biliary cirrhosis. Light microscopic observation
      was correlated to the gross appearance with cholecystitis, fatty liver changes,
      fibrous septa, and generalized cirrhosis. The range of worm burden fluctuated
      from 1 to 25 worms with large body size, which was correlated with pathology.
      These novel findings indicate that O. viverrini infection can cause liver and
      biliary cirrhosis in gerbils, depending on the worm burden, worm size, and
      habitat.
FAU - Wonkchalee, Orasa
AU  - Wonkchalee O
AD  - Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 
      40002, Thailand.
FAU - Boonmars, Thidarut
AU  - Boonmars T
FAU - Kaewkes, Sasithron
AU  - Kaewkes S
FAU - Chamgramol, Yaovaluk
AU  - Chamgramol Y
FAU - Pairojkul, Chawalit
AU  - Pairojkul C
FAU - Wu, Zhiliang
AU  - Wu Z
FAU - Juasook, Amornrat
AU  - Juasook A
FAU - Sudsarn, Pakkayanee
AU  - Sudsarn P
FAU - Boonjaraspinyo, Sirintip
AU  - Boonjaraspinyo S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110222
PL  - Germany
TA  - Parasitol Res
JT  - Parasitology research
JID - 8703571
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - Gerbillinae/*parasitology
MH  - Histocytochemistry
MH  - Liver Cirrhosis/parasitology/*pathology
MH  - Liver Cirrhosis, Biliary/parasitology/*pathology
MH  - Microscopy
MH  - Opisthorchiasis/*complications/parasitology/pathology
MH  - Opisthorchis/*pathogenicity
MH  - Rodent Diseases/parasitology/pathology
EDAT- 2011/02/23 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/02/23 06:00
PHST- 2010/12/28 00:00 [received]
PHST- 2011/02/01 00:00 [accepted]
PHST- 2011/02/23 06:00 [entrez]
PHST- 2011/02/23 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/s00436-011-2282-y [doi]
PST - ppublish
SO  - Parasitol Res. 2011 Sep;109(3):545-51. doi: 10.1007/s00436-011-2282-y. Epub 2011 
      Feb 22.


PMID- 21339390
OWN - NLM
STAT- MEDLINE
DCOM- 20110915
LR  - 20110520
IS  - 1744-5019 (Electronic)
IS  - 0360-5310 (Linking)
VI  - 36
IP  - 2
DP  - 2011 Apr
TI  - The rise of empirical research in medical ethics: a MacIntyrean critique and
      proposal.
PG  - 206-16
LID - 10.1093/jmp/jhr001 [doi]
AB  - Hume's is/ought distinction has long limited the role of empirical research in
      ethics, saying that data about what something is cannot yield conclusions about
      the way things ought to be. However, interest in empirical research in ethics has
      been growing despite this countervailing principle. We attribute some of this
      increased interest to a conceptual breakdown of the is/ought distinction.
      MacIntyre, in reviewing the history of the is/ought distinction, argues that is
      and ought are not strictly separate realms but exist in a close relationship that
      is clarified by adopting a teleological orientation. We propose that, instead of 
      recovering a teleological orientation, society tends to generate its own goals
      via democratic methods like those described by Rousseau or adopt agnosticism
      about teleology such as described by Richard Rorty. In both latter scenarios, the
      distinction between is and ought is obscured, and the role for empirical research
      grows, but for controversial reasons. MacIntyre warns that the is/ought
      distinction should remain, but reminds ethicists to make careful arguments about 
      when and why it is legitimate to move from is to ought.
FAU - Lawrence, Ryan E
AU  - Lawrence RE
AD  - Columbia University Medical Center, Department of Psychiatry, New York State
      Psychiatric Institute, 1051 Riverside Drive, Box 103, New York, NY 10032, USA.
      rlawrence@uchicago.edu
FAU - Curlin, Farr A
AU  - Curlin FA
LA  - eng
PT  - Journal Article
DEP - 20110221
PL  - United States
TA  - J Med Philos
JT  - The Journal of medicine and philosophy
JID - 7610512
SB  - IM
MH  - *Empirical Research
MH  - *Ethics, Medical
MH  - Humans
MH  - Morals
MH  - Philosophy, Medical
EDAT- 2011/02/23 06:00
MHDA- 2011/09/16 06:00
CRDT- 2011/02/23 06:00
PHST- 2011/02/23 06:00 [entrez]
PHST- 2011/02/23 06:00 [pubmed]
PHST- 2011/09/16 06:00 [medline]
AID - jhr001 [pii]
AID - 10.1093/jmp/jhr001 [doi]
PST - ppublish
SO  - J Med Philos. 2011 Apr;36(2):206-16. doi: 10.1093/jmp/jhr001. Epub 2011 Feb 21.


PMID- 21338872
OWN - NLM
STAT- MEDLINE
DCOM- 20110408
LR  - 20110222
IS  - 1097-4199 (Electronic)
IS  - 0896-6273 (Linking)
VI  - 69
IP  - 4
DP  - 2011 Feb 24
TI  - Cognitive enhancement: promises and perils.
PG  - 595-8
LID - 10.1016/j.neuron.2011.02.012 [doi]
AB  - The potential use of drugs to enhance cognition, emotion, and executive function 
      has engendered controversy despite the fact that few such agents exist today.
      Here, I provide a context for discussions based on medical, regulatory, and
      ethical concerns that have been raised by the possibility that enhancers will
      emerge from current efforts to discover drugs for neuropsychiatric disorders.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Hyman, Steven E
AU  - Hyman SE
AD  - Office of the Provost, Massachusetts Hall, Harvard University, Cambridge, MA
      02138, USA. seh@harvard.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - 0 (Nootropic Agents)
SB  - IM
MH  - Cognition/*drug effects/physiology
MH  - Cognition Disorders/drug therapy
MH  - Humans
MH  - Nootropic Agents/*pharmacology/therapeutic use
EDAT- 2011/02/23 06:00
MHDA- 2011/04/09 06:00
CRDT- 2011/02/23 06:00
PHST- 2011/02/23 06:00 [entrez]
PHST- 2011/02/23 06:00 [pubmed]
PHST- 2011/04/09 06:00 [medline]
AID - S0896-6273(11)00109-7 [pii]
AID - 10.1016/j.neuron.2011.02.012 [doi]
PST - ppublish
SO  - Neuron. 2011 Feb 24;69(4):595-8. doi: 10.1016/j.neuron.2011.02.012.


PMID- 21338544
OWN - NLM
STAT- MEDLINE
DCOM- 20110803
LR  - 20110317
IS  - 1744-134X (Electronic)
IS  - 1744-1331 (Linking)
VI  - 6
IP  - 2
DP  - 2011 Apr
TI  - Commentary 1: The ethics of licensing smokers.
PG  - 273-7; discussion 283-5
LID - 10.1017/S1744133111000041 [doi]
FAU - Wilkinson, T M
AU  - Wilkinson TM
AD  - Department of Political Studies, University of Auckland, Auckland, New Zealand.
      m.wilkinson@auckland.ac.nz
LA  - eng
PT  - Comment
PT  - Journal Article
DEP - 20110222
PL  - England
TA  - Health Econ Policy Law
JT  - Health economics, policy, and law
JID - 101247224
SB  - IM
CON - Health Econ Policy Law. 2011 Apr;6(2):265-72. PMID: 21338546
MH  - Humans
MH  - Licensure/*ethics
MH  - Policy Making
MH  - Russia
MH  - *Smoking
MH  - Tobacco Industry
MH  - Tobacco Use Disorder
EDAT- 2011/02/23 06:00
MHDA- 2011/08/04 06:00
CRDT- 2011/02/23 06:00
PHST- 2011/02/23 06:00 [entrez]
PHST- 2011/02/23 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
AID - S1744133111000041 [pii]
AID - 10.1017/S1744133111000041 [doi]
PST - ppublish
SO  - Health Econ Policy Law. 2011 Apr;6(2):273-7; discussion 283-5. doi:
      10.1017/S1744133111000041. Epub 2011 Feb 22.


PMID- 21338514
OWN - NLM
STAT- MEDLINE
DCOM- 20110607
LR  - 20211020
IS  - 1746-6148 (Electronic)
IS  - 1746-6148 (Linking)
VI  - 7
DP  - 2011 Feb 21
TI  - Reported analgesic administration to rabbits undergoing experimental surgical
      procedures.
PG  - 12
LID - 10.1186/1746-6148-7-12 [doi]
AB  - BACKGROUND: It has become widely accepted that whenever animals are used in
      scientific procedures, the 3Rs principle of replacement, reduction and refinement
      described by William Russell and Rex Burch should be adhered to. Animals should
      be replaced with non-sentient alternatives if possible, the number of animals
      used should be reduced and experimental procedures should be refined to minimise 
      pain, suffering and distress. Administration of analgesic agents to animals
      undergoing surgical procedures is a refinement used to alleviate pain. In this
      study, a structured literature review was carried out to examine current trends
      in analgesic administration to rabbits undergoing experimental surgical
      procedures. RESULTS: 128 papers from 51 peer-reviewed journals were selected for 
      inclusion in this review. Reporting administration of systemic analgesia to
      rabbits in peer-reviewed scientific papers increased significantly from 16% to
      50% between 1995-1997 and 2005-2007 (P < 0.001). Papers that reported ethical
      approval were more likely than papers that did not specify approval to report
      systemic analgesic administration (P < 0.001). When systemic analgesics were
      administered, buprenorphine was the most frequently used agent and non-steroidal 
      anti-inflammatory drugs were used less frequently than opioids in both time
      periods. CONCLUSIONS: Although this review provides evidence that systemic
      analgesic administration to rabbits undergoing surgical procedures is increasing,
      rabbits do not always receive analgesia when they undergo experimental surgery.
      Other practices in rabbit perioperative care that could be improved, highlighted 
      by this survey include: 1) changing the timing of analgesic administration by
      giving systemic analgesics pre- or perioperatively rather than only
      postoperatively, 2) using multimodal analgesia when pain is likely to be moderate
      to severe and 3) increasing the use of non-steroidal anti-inflammatory drugs and 
      use of other techniques such as epidural analgesia particularly for orthopaedic
      procedures.
FAU - Coulter, Claire A
AU  - Coulter CA
AD  - Comparative Biology Centre, Newcastle University, Newcastle upon Tyne, UK.
FAU - Flecknell, Paul A
AU  - Flecknell PA
FAU - Leach, Matthew C
AU  - Leach MC
FAU - Richardson, Claire A
AU  - Richardson CA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110221
PL  - England
TA  - BMC Vet Res
JT  - BMC veterinary research
JID - 101249759
RN  - 0 (Analgesics)
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 40D3SCR4GZ (Buprenorphine)
SB  - IM
MH  - Analgesia/*statistics & numerical data/trends
MH  - Analgesics/*administration & dosage
MH  - Analgesics, Opioid/administration & dosage
MH  - Animals
MH  - Animals, Laboratory/*surgery
MH  - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage
MH  - Buprenorphine/administration & dosage
MH  - Rabbits/*surgery
PMC - PMC3058034
EDAT- 2011/02/23 06:00
MHDA- 2011/06/08 06:00
CRDT- 2011/02/23 06:00
PHST- 2010/04/12 00:00 [received]
PHST- 2011/02/21 00:00 [accepted]
PHST- 2011/02/23 06:00 [entrez]
PHST- 2011/02/23 06:00 [pubmed]
PHST- 2011/06/08 06:00 [medline]
AID - 1746-6148-7-12 [pii]
AID - 10.1186/1746-6148-7-12 [doi]
PST - epublish
SO  - BMC Vet Res. 2011 Feb 21;7:12. doi: 10.1186/1746-6148-7-12.


PMID- 21338492
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20211020
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 12
DP  - 2011 Feb 21
TI  - Intrathecal opioid versus ultrasound guided fascia iliaca plane block for
      analgesia after primary hip arthroplasty: study protocol for a randomised,
      blinded, noninferiority controlled trial.
PG  - 51
LID - 10.1186/1745-6215-12-51 [doi]
AB  - BACKGROUND: Hip replacement surgery is increasingly common due to an ageing
      population, and rising levels of obesity. The provision of excellent pain relief 
      with minimal side effects is important in order to facilitate patient
      mobilisation and rehabilitation.Spinal opioids provide excellent analgesia but
      are associated with adverse effects. The fascia-iliaca block is an alternative
      technique which provides analgesia to the nerves innervating the hip. The success
      of fascia iliaca blocks has been demonstrated to be superior when using
      ultrasound compared to landmark techniques. However, the clinical benefit of this
      improvement has yet to be investigated.The aim of this study is to compare the
      efficacy and safety of ultrasound guided fascia iliaca block with spinal morphine
      for hip replacement surgery. METHODS/DESIGN: This study is a randomised, blinded,
      placebo-controlled, noninferiority trial. Patients scheduled to undergo
      unilateral primary hip arthroplasty will receive a study information sheet and
      consent will be obtained in keeping with the Declaration of Helsinki. Patients
      will be randomised to receive either; (i) Ultrasound guided fascia iliaca block
      using levobupivacaine, plus spinal anaesthesia with hyperbaric bupivacaine
      containing no morphine, or (ii) sham ultrasound guided fascia iliaca block
      performed with sterile saline, and spinal anaesthesia containing hyperbaric
      bupivacaine and 0.1 mg of spinal morphine.A total of 108 patients will be
      recruited. Primary outcome is post-operative morphine consumption in a 24 hour
      period. Secondary outcomes include; pain scores at 3, 6, 12, 24, 36 and 48 hours,
      episodes of respiratory depression, hypotension, nausea and vomiting, pruritus,
      sedation, time to first mobilisation and patient satisfaction. CONCLUSIONS: There
      are no studies to date comparing ultrasound guided fascia iliaca block with
      spinal morphine for pain control after hip arthroplasty. If the ultrasound guided
      fascia iliaca block provides pain relief which is not inferior to spinal
      morphine, then morphine could be removed from the spinal injection. This could
      reduce side effects and improve patient safety. TRIAL REGISTRATION: This study
      has been approved by the West of Scotland Research Ethics Committee 4 (reference 
      no. 10/S0704/43) and is registered with ClinicalTrials.gov (reference no.
      NCT01217294).
FAU - Kearns, Rachel J
AU  - Kearns RJ
AD  - Glasgow University Academic Unit of Anaesthesia, Pain and Critical Care Medicine,
      Glasgow Royal Infirmary, Glasgow. rkearns@doctors.org.uk
FAU - Macfarlane, Alan J R
AU  - Macfarlane AJ
FAU - Anderson, Keith J
AU  - Anderson KJ
FAU - Kinsella, John
AU  - Kinsella J
LA  - eng
SI  - ClinicalTrials.gov/NCT01217294
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110221
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
RN  - 0 (Analgesics, Non-Narcotic)
RN  - 0 (Analgesics, Opioid)
RN  - 362O9ITL9D (Acetaminophen)
RN  - 76I7G6D29C (Morphine)
SB  - IM
MH  - Acetaminophen/administration & dosage
MH  - Analgesia/adverse effects/*methods
MH  - Analgesia, Patient-Controlled
MH  - Analgesics, Non-Narcotic/administration & dosage
MH  - Analgesics, Opioid/*administration & dosage/adverse effects
MH  - *Arthroplasty, Replacement, Hip/adverse effects
MH  - Double-Blind Method
MH  - Humans
MH  - Injections, Spinal
MH  - Morphine/*administration & dosage/adverse effects
MH  - *Nerve Block/adverse effects
MH  - Pain Measurement
MH  - Pain, Postoperative/etiology/*prevention & control
MH  - *Research Design
MH  - Scotland
MH  - Time Factors
MH  - Treatment Outcome
MH  - *Ultrasonography, Interventional
PMC - PMC3050756
EDAT- 2011/02/23 06:00
MHDA- 2011/06/29 06:00
CRDT- 2011/02/23 06:00
PHST- 2010/11/28 00:00 [received]
PHST- 2011/02/21 00:00 [accepted]
PHST- 2011/02/23 06:00 [entrez]
PHST- 2011/02/23 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
AID - 1745-6215-12-51 [pii]
AID - 10.1186/1745-6215-12-51 [doi]
PST - epublish
SO  - Trials. 2011 Feb 21;12:51. doi: 10.1186/1745-6215-12-51.


PMID- 21338481
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20211020
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 12
DP  - 2011 Feb 21
TI  - Developing a placebo-controlled trial in surgery: issues of design, acceptability
      and feasibility.
PG  - 50
LID - 10.1186/1745-6215-12-50 [doi]
AB  - BACKGROUND: Surgical placebos are controversial. This in-depth study explored the
      design, acceptability, and feasibility issues relevant to designing a surgical
      placebo-controlled trial for the evaluation of the clinical and cost
      effectiveness of arthroscopic lavage for the management of people with
      osteoarthritis of the knee in the UK. METHODS: Two surgeon focus groups at a UK
      national meeting for orthopaedic surgeons and one regional surgeon focus group
      (41 surgeons); plenary discussion at a UK national meeting for orthopaedic
      anaesthetists (130 anaesthetists); three focus groups with anaesthetists (one
      national, two regional; 58 anaesthetists); two focus groups with members of the
      patient organisation Arthritis Care (7 participants); telephone interviews with
      people on consultant waiting lists from two UK regional centres (15
      participants); interviews with Chairs of UK ethics committees (6 individuals);
      postal surveys of members of the British Association of Surgeons of the Knee (382
      surgeons) and members of the British Society of Orthopaedic Anaesthetists (398
      anaesthetists); two centre pilot (49 patients assessed). RESULTS: There was
      widespread acceptance that evaluation of arthroscopic lavage had to be conducted 
      with a placebo control if scientific rigour was not to be compromised. The choice
      of placebo surgical procedure (three small incisions) proved easier than the
      method of anaesthesia (general anaesthesia). General anaesthesia, while an
      excellent mimic, was more intrusive and raised concerns among some stakeholders
      and caused extensive discussion with local decision-makers when seeking formal
      approval for the pilot.Patients were willing to participate in a pilot with a
      placebo arm; although some patients when allocated to surgery became apprehensive
      about the possibility of receiving placebo, and withdrew. Placebo surgery was
      undertaken successfully. CONCLUSIONS: Our study illustrated the opposing and
      often strongly held opinions about surgical placebos, the ethical issues
      underpinning this controversy, and the challenges that exist even when ethics
      committee approval has been granted. It showed that a placebo-controlled trial
      could be conducted in principle, albeit with difficulty. It also highlighted that
      not only does a placebo-controlled trial in surgery have to be ethically and
      scientifically acceptable but that it also must be a feasible course of action.
      The place of placebo-controlled surgical trials more generally is likely to be
      limited and require specific circumstances to be met. Suggested criteria are
      presented. TRIAL REGISTRATION NUMBER: The trial was assigned ISRCTN02328576
      through http://controlled-trials.com/ in June 2006. The first patient was
      randomised to the pilot in July 2007.
FAU - Campbell, M K
AU  - Campbell MK
AD  - Health Services Research Unit, University of Aberdeen, Aberdeen, UK.
      m.k.campbell@abdn.ac.uk
FAU - Entwistle, V A
AU  - Entwistle VA
FAU - Cuthbertson, B H
AU  - Cuthbertson BH
FAU - Skea, Z C
AU  - Skea ZC
FAU - Sutherland, A G
AU  - Sutherland AG
FAU - McDonald, A M
AU  - McDonald AM
FAU - Norrie, J D
AU  - Norrie JD
FAU - Carlson, R V
AU  - Carlson RV
FAU - Bridgman, S
AU  - Bridgman S
CN  - KORAL study group
LA  - eng
SI  - ISRCTN/ISRCTN02328576
GR  - 03/48/01/DH_/Department of Health/United Kingdom
GR  - HSRU1/CSO_/Chief Scientist Office/United Kingdom
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110221
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
SB  - IM
MH  - Anesthesia, General
MH  - *Arthroscopy/ethics
MH  - Attitude of Health Personnel
MH  - Feasibility Studies
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Osteoarthritis, Knee/*surgery
MH  - Patient Acceptance of Health Care
MH  - *Patient Selection/ethics
MH  - Pilot Projects
MH  - Placebo Effect
MH  - *Research Design
MH  - Therapeutic Irrigation
MH  - Treatment Outcome
MH  - United Kingdom
PMC - PMC3052178
IR  - Cotton S
FIR - Cotton, Seonaidh
IR  - Donaldson A
FIR - Donaldson, Angela
IR  - Fitzpatrick R
FIR - Fitzpatrick, Ray
IR  - Grant A
FIR - Grant, Adrian
IR  - Gray A
FIR - Gray, Alastair
IR  - Hutchison J
FIR - Hutchison, James
IR  - Johnston M
FIR - Johnston, Marie
IR  - Murray D
FIR - Murray, David
IR  - Ramsay C
FIR - Ramsay, Craig
IR  - Rowley D
FIR - Rowley, David
IR  - Vale L
FIR - Vale, Luke
IR  - Wigderowitz C
FIR - Wigderowitz, Carlos
EDAT- 2011/02/23 06:00
MHDA- 2011/06/29 06:00
CRDT- 2011/02/23 06:00
PHST- 2010/11/03 00:00 [received]
PHST- 2011/02/21 00:00 [accepted]
PHST- 2011/02/23 06:00 [entrez]
PHST- 2011/02/23 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
AID - 1745-6215-12-50 [pii]
AID - 10.1186/1745-6215-12-50 [doi]
PST - epublish
SO  - Trials. 2011 Feb 21;12:50. doi: 10.1186/1745-6215-12-50.


PMID- 21338262
OWN - NLM
STAT- MEDLINE
DCOM- 20110622
LR  - 20181201
IS  - 1757-6199 (Electronic)
IS  - 1757-6180 (Linking)
VI  - 3
IP  - 4
DP  - 2011 Feb
TI  - Determination of oseltamivir (Tamiflu(R)) and oseltamivir carboxylate in dried
      blood spots using offline or online extraction.
PG  - 421-37
LID - 10.4155/bio.11.4 [doi]
AB  - BACKGROUND: Using dried blood spots (DBS) for quantitation of the antiviral drug 
      oseltamivir (Tamiflu((R))), an ester prodrug, and its active metabolite
      oseltamivir carboxylate could provide ethical and logistic benefits. Hence, its
      feasibility was investigated using a previously developed column-switching
      LC-MS/MS method. RESULTS: Sensitivity, precision and accuracy in DBS were
      comparable to standard plasma assays. Chemically treated cards provided enhanced 
      ex vivo stability of the ester prodrug in rodent blood. Online extraction was
      realized using the manual TLC-MS interface or the fully automated Sample Card and
      Prep system. Rat pharmacokinetic study data showed good correlation between
      plasma, liquid blood and DBS. CONCLUSION: From a bioanalytical perspective, DBS
      is potentially suited for Tamiflu analysis in animals and humans. Automation of
      the process by online DBS extraction promises workload reduction and throughput
      increase.
FAU - Heinig, Katja
AU  - Heinig K
AD  - F. Hoffmann-La Roche AG, Pharma Research, Nonclinical Drug Safety, Development
      DMPK Department, Grenzacherstrasse 124, 4070 Basel, Switzerland.
      katja.heinig@roche.com
FAU - Wirz, Thomas
AU  - Wirz T
FAU - Bucheli, Franz
AU  - Bucheli F
FAU - Gajate-Perez, Almudena
AU  - Gajate-Perez A
LA  - eng
PT  - Journal Article
PL  - England
TA  - Bioanalysis
JT  - Bioanalysis
JID - 101512484
RN  - 20O93L6F9H (Oseltamivir)
RN  - K6106LV5Q8 (oseltamivir carboxylate)
SB  - IM
MH  - Analytic Sample Preparation Methods
MH  - Animals
MH  - Blood Chemical Analysis/*methods
MH  - Blood Specimen Collection/*methods
MH  - Chemical Fractionation/*methods
MH  - Chromatography, Liquid
MH  - Chromatography, Thin Layer
MH  - Humans
MH  - Male
MH  - Online Systems
MH  - Oseltamivir/*analogs & derivatives/*blood/*isolation &
      purification/pharmacokinetics
MH  - Rats
MH  - Rats, Wistar
MH  - Reproducibility of Results
MH  - Tandem Mass Spectrometry
EDAT- 2011/02/23 06:00
MHDA- 2011/06/23 06:00
CRDT- 2011/02/23 06:00
PHST- 2011/02/23 06:00 [entrez]
PHST- 2011/02/23 06:00 [pubmed]
PHST- 2011/06/23 06:00 [medline]
AID - 10.4155/bio.11.4 [doi]
PST - ppublish
SO  - Bioanalysis. 2011 Feb;3(4):421-37. doi: 10.4155/bio.11.4.


PMID- 21337264
OWN - NLM
STAT- MEDLINE
DCOM- 20110418
LR  - 20171116
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 11
IP  - 2
DP  - 2011 Feb
TI  - Behavioral equipoise: a way to resolve ethical stalemates in clinical research.
PG  - 1-8
LID - 10.1080/15265161.2010.540061 [doi]
AB  - Randomized trials depend on clinicians feeling that they are morally justified in
      allowing their patients to be randomized across treatment arms. Typically such
      justification rides on what has been called "clinical equipoise"--when there is
      disagreement of opinion among the community of experts about whether one
      treatment is better than another, then physicians can ethically enter their
      patients into a clinical trial, even if individual physicians are not at
      equipoise. Recent debates over prominent studies, however, illustrate that
      controversy can be easily created rather than dispelled by trials, with many
      clinicians choosing not to use the proven therapy until they receive more
      convincing evidence of its superiority. In such situations, we propose that a new
      standard of equipoise be used to guide decisions about the ethical justifications
      for research trials--a standard of behavioral equipoise. Under behavioral
      equipoise, a trial is potentially justifiable if it addresses behavioral
      resistance to prior scientific evidence.
FAU - Ubel, Peter A
AU  - Ubel PA
AD  - Fuqua School of Business, Duke University, Durham, NC 27708, USA.
      peter.ubel@duke.edu
FAU - Silbergleit, Robert
AU  - Silbergleit R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
RN  - EC 3.4.21.68 (Tissue Plasminogen Activator)
SB  - IM
CIN - Am J Bioeth. 2011 Feb;11(2):W1-2. PMID: 21337265
CIN - Am J Bioeth. 2011 Feb;11(2):9-10. PMID: 21337267
CIN - Am J Bioeth. 2011 Feb;11(2):10-2. PMID: 21337268
CIN - Am J Bioeth. 2011 Feb;11(2):13-4. PMID: 21337269
CIN - Am J Bioeth. 2011 Feb;11(2):14-6. PMID: 21337270
CIN - Am J Bioeth. 2011 Feb;11(2):16-7. PMID: 21337271
CIN - Am J Bioeth. 2011 Feb;11(2):18-9. PMID: 21337272
MH  - Cerebral Hemorrhage/chemically induced
MH  - Decision Making/*ethics
MH  - Emergency Medicine/ethics/standards
MH  - Ethics, Research
MH  - Evidence-Based Medicine/*ethics
MH  - *Expert Testimony/ethics
MH  - Humans
MH  - Multicenter Studies as Topic/ethics
MH  - National Institute of Neurological Disorders and Stroke (U.S.)
MH  - Physicians/ethics/psychology
MH  - Practice Patterns, Physicians'/*ethics/standards
MH  - Randomized Controlled Trials as Topic/*ethics
MH  - Stroke/drug therapy
MH  - *Therapeutic Equipoise
MH  - Thrombolytic Therapy/ethics/methods
MH  - Tissue Plasminogen Activator/administration & dosage/adverse effects
MH  - Uncertainty
MH  - United States
EDAT- 2011/02/22 06:00
MHDA- 2011/04/19 06:00
CRDT- 2011/02/22 06:00
PHST- 2011/02/22 06:00 [entrez]
PHST- 2011/02/22 06:00 [pubmed]
PHST- 2011/04/19 06:00 [medline]
AID - 933638828 [pii]
AID - 10.1080/15265161.2010.540061 [doi]
PST - ppublish
SO  - Am J Bioeth. 2011 Feb;11(2):1-8. doi: 10.1080/15265161.2010.540061.


PMID- 21336881
OWN - NLM
STAT- MEDLINE
DCOM- 20110805
LR  - 20220310
IS  - 1432-5241 (Electronic)
IS  - 0364-216X (Linking)
VI  - 35
IP  - 2
DP  - 2011 Apr
TI  - Ethical issues in plastic and reconstructive surgery.
PG  - 262-7
LID - 10.1007/s00266-011-9674-3 [doi]
AB  - Plastic, reconstructive, and cosmetic surgery refers to a variety of operations
      performed in order to repair or restore body parts to look normal or to enhance a
      certain structure or anatomy that is already normal. Several ethical
      considerations such as a patient's right for autonomy, informed consent,
      beneficence, and nonmalfeasance need to be given careful consideration. The
      principal objective of the medical profession is to render services to humanity
      with full respect for human dignity. Plastic surgeons should merit the confidence
      of patients entrusted to their care, rendering to each a full measure of service 
      and devotion. They require an extensive amount of education and training. The
      increases in demand for aesthetic plastic surgery and the advocacy of practice in
      the media have raised concerns about the circumstances under which cosmetic
      surgery is ethical and permissible. Innovative research, and new technologies
      derived from such research, almost always raises ethical and policy concerns.
      Medical ethics regulate what is, and what is not, correct in promoting plastic
      surgery to the public. It is essential to create an educated and informed public 
      about the ethical issues in the plastic and reconstructive surgery field. Plastic
      surgeons need to carefully evaluate the degree of deformity, physical and
      emotional maturity, and desired outcome of patients who request plastic surgery
      procedures. Science is a powerful force for change in modern society and plastic 
      surgeons have a responsibility to shepherd that change with thoughtful advocacy
      and careful ethical scrutiny of their own behavior.
FAU - Sterodimas, Aris
AU  - Sterodimas A
AD  - Plastic Surgery Department, Pontifical Catholic University of Rio de Janeiro,
      Carlos Chagas Post-Graduate Medical Institute, RJ, Brazil. steroaris@yahoo.com
FAU - Radwanski, Henrique N
AU  - Radwanski HN
FAU - Pitanguy, Ivo
AU  - Pitanguy I
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110220
PL  - United States
TA  - Aesthetic Plast Surg
JT  - Aesthetic plastic surgery
JID - 7701756
SB  - IM
CIN - Aesthetic Plast Surg. 2011 Apr;35(2):268-9. PMID: 21424171
CIN - Aesthetic Plast Surg. 2013 Jun;37(3):648-9. PMID: 23494027
MH  - Beneficence
MH  - Brazil
MH  - Female
MH  - Humans
MH  - Informed Consent/ethics
MH  - Male
MH  - Patient Rights/*ethics
MH  - *Personal Autonomy
MH  - Physician-Patient Relations
MH  - Principle-Based Ethics
MH  - Reconstructive Surgical Procedures/*ethics/methods
MH  - Risk Factors
MH  - Surgery, Plastic/*ethics/methods
EDAT- 2011/02/22 06:00
MHDA- 2011/08/06 06:00
CRDT- 2011/02/22 06:00
PHST- 2010/07/18 00:00 [received]
PHST- 2011/01/24 00:00 [accepted]
PHST- 2011/02/22 06:00 [entrez]
PHST- 2011/02/22 06:00 [pubmed]
PHST- 2011/08/06 06:00 [medline]
AID - 10.1007/s00266-011-9674-3 [doi]
PST - ppublish
SO  - Aesthetic Plast Surg. 2011 Apr;35(2):262-7. doi: 10.1007/s00266-011-9674-3. Epub 
      2011 Feb 20.


PMID- 21336697
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20211020
IS  - 1543-0154 (Electronic)
IS  - 0885-8195 (Linking)
VI  - 26
IP  - 2
DP  - 2011 Jun
TI  - Ethics corner--Biospecimen Banking: poetry of the flesh.
PG  - 212-4
LID - 10.1007/s13187-011-0206-2 [doi]
AB  - This Ethics Corners poses a series of queries concerning Biospecimen Banking.
      Particular attention is given to ownership v custodianship, and informed consent.
FAU - Michalek, Arthur M
AU  - Michalek AM
AD  - D'Youville College, Buffalo, NY, USA. michalea@dyc.edu
FAU - Wicher, Camille C
AU  - Wicher CC
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Cancer Educ
JT  - Journal of cancer education : the official journal of the American Association
      for Cancer Education
JID - 8610343
SB  - IM
MH  - Biomedical Research
MH  - Confidentiality
MH  - *Ethics, Medical
MH  - Humans
MH  - Informed Consent
MH  - Ownership
MH  - *Specimen Handling
MH  - *Tissue Banks
EDAT- 2011/02/22 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/02/22 06:00
PHST- 2011/02/22 06:00 [entrez]
PHST- 2011/02/22 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 10.1007/s13187-011-0206-2 [doi]
PST - ppublish
SO  - J Cancer Educ. 2011 Jun;26(2):212-4. doi: 10.1007/s13187-011-0206-2.


PMID- 21336181
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20220408
IS  - 1556-1380 (Electronic)
IS  - 1556-0864 (Linking)
VI  - 6
IP  - 4
DP  - 2011 Apr
TI  - The feasibility study of Carboplatin plus Etoposide for advanced small cell lung 
      cancer with idiopathic interstitial pneumonias.
PG  - 801-7
LID - 10.1097/JTO.0b013e3182103d3c [doi]
AB  - BACKGROUND: Idiopathic interstitial pneumonias (IIPs) are among the most common
      complications in patients with lung cancer. In such patients with cancer, the
      most serious expression of toxicity in Japan is acute exacerbation of IIPs caused
      by anticancer treatment. Nevertheless, there has been no consensus and no
      evidence presented, regarding optimal treatment for advanced lung cancer with
      IIP. PATIENTS AND METHODS: Chemotherapy-naive patients with advanced small cell
      lung cancer (SCLC) with IIP who were ineligible for curative radiotherapy were
      enrolled. Patients received carboplatin every 21 days at a dose of area under the
      curve 6.0 on day 1 and etoposide at a dose of 100 mg/m on days 1 to 3. RESULTS:
      Between July 2002 and October 2008, 17 patients with SCLC with IIP, including 14 
      men, eight of whom were diagnosed with idiopathic pulmonary fibrosis, were
      enrolled and treated for a mean of 3.5 cycles of carboplatin plus etoposide. One 
      patient (5.9%; 95% confidence interval, 0-18.4%) with clinically confirmed
      idiopathic pulmonary fibrosis had acute exacerbation of IIPs associated with the 
      treatment. The overall response rate was 88.2%. The median progression-free
      survival, median survival time, and 1-year survival rate were 5.5 months, 8.7
      months, and 29.4%, respectively. CONCLUSION: This is the first report indicating 
      that patients with advanced SCLC with IIPs may benefit from chemotherapy.
      Patients with advanced SCLC with IIP treated with etoposide and carboplatin
      combination chemotherapy gain benefits, with safety equivalent to that seen in
      patients without IIP. The results from this study would support, on ethical
      grounds, the conduct of a large-scale study to evaluate this regimen.
FAU - Minegishi, Yuji
AU  - Minegishi Y
AD  - Division of Pulmonary medicine, Infectious disease, and Oncology, Department of
      Internal Medicine, Nippon Mediccl School, Tokyo, Japan. yminegis@nms.ac.jp
FAU - Kuribayashi, Hidehiko
AU  - Kuribayashi H
FAU - Kitamura, Kazuhiro
AU  - Kitamura K
FAU - Mizutani, Hideki
AU  - Mizutani H
FAU - Kosaihira, Seiji
AU  - Kosaihira S
FAU - Okano, Tetsuya
AU  - Okano T
FAU - Seike, Masahiro
AU  - Seike M
FAU - Azuma, Arata
AU  - Azuma A
FAU - Yoshimura, Akinobu
AU  - Yoshimura A
FAU - Kudoh, Shoji
AU  - Kudoh S
FAU - Gemma, Akihiko
AU  - Gemma A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Thorac Oncol
JT  - Journal of thoracic oncology : official publication of the International
      Association for the Study of Lung Cancer
JID - 101274235
RN  - 6PLQ3CP4P3 (Etoposide)
RN  - BG3F62OND5 (Carboplatin)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
MH  - Carboplatin/administration & dosage
MH  - Etoposide/administration & dosage
MH  - Feasibility Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Idiopathic Interstitial Pneumonias/complications/*drug therapy
MH  - Lung Neoplasms/complications/*drug therapy
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Prospective Studies
MH  - Small Cell Lung Carcinoma/complications/*drug therapy
MH  - Survival Rate
EDAT- 2011/02/22 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/02/22 06:00
PHST- 2011/02/22 06:00 [entrez]
PHST- 2011/02/22 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 10.1097/JTO.0b013e3182103d3c [doi]
AID - S1556-0864(15)33398-0 [pii]
PST - ppublish
SO  - J Thorac Oncol. 2011 Apr;6(4):801-7. doi: 10.1097/JTO.0b013e3182103d3c.


PMID- 21336006
OWN - NLM
STAT- MEDLINE
DCOM- 20110823
LR  - 20151119
IS  - 1423-0372 (Electronic)
IS  - 1011-6125 (Linking)
VI  - 89
IP  - 2
DP  - 2011
TI  - The contemporary practice of psychiatric surgery: results from a survey of North 
      American functional neurosurgeons.
PG  - 103-10
LID - 10.1159/000323545 [doi]
AB  - BACKGROUND: Deep brain stimulation (DBS) for psychiatric indications is becoming 
      increasingly safe and effective. As a result, the treatment of these conditions
      by neurosurgeons is becoming more widespread and a larger part of the functional 
      neurosurgeons' practice. Given the troubled history of the field and its current 
      renaissance, it is important to evaluate current practices, to serve as a
      baseline for future comparison, and to gauge changing cultural attitudes towards 
      invasive neuromodulation. OBJECTIVES: The purpose of this study was to obtain a
      snapshot of the practice of the contemporary functional neurosurgeon engaged in
      psychiatric surgery. Current practices as well as attitudes towards the direction
      of the field and its future were also investigated. METHODS: We designed an
      online survey and distributed it electronically to 299 functional neurosurgeons
      in North America identified by membership in the World Society for Stereotactic
      and Functional Neurosugery. Subsequent statistical and thematic analysis was
      performed on the data obtained. RESULTS: Of 299 surveys sent out, 84 were
      completed (28%). Fifty percent of functional neurosurgeons are currently engaged 
      in some form of psychiatric surgery, with DBS for obsessive-compulsive disorder
      and depression accounting for most cases. Most surgeons see psychiatric surgery
      as a growing field, with multidisciplinary teams and a greater engagement with
      psychiatry necessary for the expansion of the field. Opinions differed
      substantially on hypothetical scenarios dealing with surgical cognitive
      enhancement, with some in favour of it, citing patient autonomy and choice, and
      others drawing a clear distinction between pathologic and non-pathologic states. 
      CONCLUSIONS: Surgery for psychiatric indications is a growing field in the
      contemporary functional neurosurgeon's practice. Most neurosurgeons see the field
      continuing to grow and psychiatric surgery becoming a larger part of their daily 
      practice, with the appropriate ethical and psychiatric oversight. Future editions
      of this survey and their results can be used to trace the development and growth 
      of the field as technology and cultural attitudes continue to evolve.
CI  - Copyright (c) 2011 S. Karger AG, Basel.
FAU - Lipsman, Nir
AU  - Lipsman N
AD  - Division of Neurosurgery, Toronto Western Hospital, University Health Network,
      University of Toronto, Toronto, Ont., Canada.
FAU - Mendelsohn, Daniel
AU  - Mendelsohn D
FAU - Taira, Takaomi
AU  - Taira T
FAU - Bernstein, Mark
AU  - Bernstein M
LA  - eng
GR  - NNF 80045/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110217
PL  - Switzerland
TA  - Stereotact Funct Neurosurg
JT  - Stereotactic and functional neurosurgery
JID - 8902881
SB  - IM
MH  - Attitude of Health Personnel
MH  - Data Collection
MH  - Deep Brain Stimulation/*trends
MH  - Depression/epidemiology/therapy
MH  - Humans
MH  - Mental Disorders/epidemiology/*therapy
MH  - Neurosurgery/*trends
MH  - North America/epidemiology
MH  - Obsessive-Compulsive Disorder/epidemiology/therapy
MH  - Practice Patterns, Physicians'/*trends
MH  - Treatment Outcome
EDAT- 2011/02/22 06:00
MHDA- 2011/08/24 06:00
CRDT- 2011/02/22 06:00
PHST- 2010/09/13 00:00 [received]
PHST- 2010/12/13 00:00 [accepted]
PHST- 2011/02/22 06:00 [entrez]
PHST- 2011/02/22 06:00 [pubmed]
PHST- 2011/08/24 06:00 [medline]
AID - 000323545 [pii]
AID - 10.1159/000323545 [doi]
PST - ppublish
SO  - Stereotact Funct Neurosurg. 2011;89(2):103-10. doi: 10.1159/000323545. Epub 2011 
      Feb 17.


PMID- 21335848
OWN - NLM
STAT- MEDLINE
DCOM- 20110517
LR  - 20110221
IS  - 0926-9630 (Print)
IS  - 0926-9630 (Linking)
VI  - 163
DP  - 2011
TI  - Virtual reality applications for addressing the needs of those aging with
      disability.
PG  - 510-6
AB  - As persons with disabilities age, progressive declines in health and medical
      status can challenge the adaptive resources required to maintain functional
      independence and quality of life [1]. These challenges are further compounded by 
      economic factors, medication side effects, loss of a spouse or caregiver, and
      psychosocial disorders [1-2]. With the gradual loss of functional independence
      and increased reliance on others for transportation, access to general medical
      and rehabilitation care can be jeopardized [2]. The combination of these factors 
      when seen in the context of the average increase in lifespan in industrialized
      societies has lead to a growing crisis that is truly global in proportion. While 
      research indicates that functional motor capacity can be improved, maintained, or
      recovered via consistent participation in a motor exercise and rehabilitation
      regimen [3], independent adherence to such preventative and/or rehabilitative
      programming outside the clinic setting is notoriously low [1]. This state of
      affairs has produced a compelling and ethical motivation to address the needs of 
      individuals who are aging with disabilities by promoting home-based access to
      low-cost, interactive virtual reality (VR) systems designed to engage and
      motivate individuals to participate with "game"-driven physical activities and
      rehabilitation programming. The creation of such systems could serve to enhance, 
      maintain and rehabilitate the sensorimotor processes that are needed to maximize 
      independence and quality of life. This is the theme of the research to be
      presented at this MMVR workshop.
FAU - Rizzo, Albert
AU  - Rizzo A
AD  - University of Southern California, Institute for Creative Technologies, Playa
      Vista, CA 90064, USA. arizzo@usc.edu
FAU - Requejo, Phil
AU  - Requejo P
FAU - Winstein, Carolee J
AU  - Winstein CJ
FAU - Lange, Belinda
AU  - Lange B
FAU - Ragusa, Gisele
AU  - Ragusa G
FAU - Merians, Alma
AU  - Merians A
FAU - Patton, James
AU  - Patton J
FAU - Banerjee, Pat
AU  - Banerjee P
FAU - Aisen, Mindy
AU  - Aisen M
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Stud Health Technol Inform
JT  - Studies in health technology and informatics
JID - 9214582
MH  - *Activities of Daily Living
MH  - Aged
MH  - Aged, 80 and over
MH  - Disabled Persons/*rehabilitation
MH  - Female
MH  - Humans
MH  - Male
MH  - Surgery, Computer-Assisted/*methods
MH  - Therapy, Computer-Assisted/*methods
MH  - United States
MH  - *User-Computer Interface
MH  - *Video Games
EDAT- 2011/02/22 06:00
MHDA- 2011/05/18 06:00
CRDT- 2011/02/22 06:00
PHST- 2011/02/22 06:00 [entrez]
PHST- 2011/02/22 06:00 [pubmed]
PHST- 2011/05/18 06:00 [medline]
PST - ppublish
SO  - Stud Health Technol Inform. 2011;163:510-6.


PMID- 21335724
OWN - NLM
STAT- MEDLINE
DCOM- 20110622
LR  - 20161125
IS  - 0926-9630 (Print)
IS  - 0926-9630 (Linking)
VI  - 164
DP  - 2011
TI  - Who's users? Participation and empowerment in socio-technical approaches to
      health IT developments.
PG  - 280-5
AB  - Health informatics researchers advocating socio-technical approaches to the
      design, implementation and evaluation of health information technology (HIT)
      consistently promote the important role of users. Aside from conventional ethical
      and legal considerations around their involvement, there are a number of
      philosophical and methodological issues that have received less attention because
      of the tendency for researchers to assume the term 'user' is well defined and
      understood. It is however, evident that there are significant differences amongst
      users, and differences in how researchers engage, involve and interact with them 
      during health IT developments. Failure to acknowledge these differences and their
      impact on Health IT developments makes comparisons across different studies
      problematic and raises fundamental questions about participation and empowerment 
      of end-users in our developments. This paper re-examines the term user in the
      context of socio-technical approaches to HIT and presents a preliminary approach 
      to differentiating between types of users and our changing expectations of their 
      roles in enhancing different HIT projects across design, implementation and
      evaluation.
FAU - Kushniruk, Andre W
AU  - Kushniruk AW
AD  - School of Health Information Science, University of Victoria, Victoria, Canada.
FAU - Turner, Paul
AU  - Turner P
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Stud Health Technol Inform
JT  - Studies in health technology and informatics
JID - 9214582
MH  - *Community Participation
MH  - *Equipment Design
MH  - *Medical Informatics
MH  - *User-Computer Interface
EDAT- 2011/02/22 06:00
MHDA- 2011/06/23 06:00
CRDT- 2011/02/22 06:00
PHST- 2011/02/22 06:00 [entrez]
PHST- 2011/02/22 06:00 [pubmed]
PHST- 2011/06/23 06:00 [medline]
PST - ppublish
SO  - Stud Health Technol Inform. 2011;164:280-5.


PMID- 21335703
OWN - NLM
STAT- MEDLINE
DCOM- 20110622
LR  - 20110221
IS  - 0926-9630 (Print)
IS  - 0926-9630 (Linking)
VI  - 164
DP  - 2011
TI  - e-Health promises and challenges: some ethical considerations.
PG  - 148-53
AB  - eHealth is a cost-effective and efficient way of providing health care to
      patients who would otherwise be excluded or underserviced. However, eHealth also 
      presents a series of ethical and legal challenges which, if not met before its
      implementation, can undermine its success. Among other things, privacy, consent
      and liability are implicated, as are changes in the health care
      professional-patient relationship and in the role of health informatics
      professionals. Legacy systems and interoperability present further challenges,
      and outsourcing may pose special problems. This paper highlights some of these
      issues and outlines their implications.
FAU - Kluge, Eike-Henner W
AU  - Kluge EH
AD  - University of Victoria, Victoria, British Columbia, Canada. ekluge@uvic.ca
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Stud Health Technol Inform
JT  - Studies in health technology and informatics
JID - 9214582
MH  - Confidentiality/ethics
MH  - Electronic Health Records/*ethics
MH  - Liability, Legal
MH  - Outsourced Services
EDAT- 2011/02/22 06:00
MHDA- 2011/06/23 06:00
CRDT- 2011/02/22 06:00
PHST- 2011/02/22 06:00 [entrez]
PHST- 2011/02/22 06:00 [pubmed]
PHST- 2011/06/23 06:00 [medline]
PST - ppublish
SO  - Stud Health Technol Inform. 2011;164:148-53.


PMID- 21335696
OWN - NLM
STAT- MEDLINE
DCOM- 20110622
LR  - 20110221
IS  - 0926-9630 (Print)
IS  - 0926-9630 (Linking)
VI  - 164
DP  - 2011
TI  - The use of biometrics in the Personal Health Record (PHR).
PG  - 110-6
AB  - The emergence of the Personal Health Record (PHR) has made individual health
      information more readily accessible to a wide range of users including patients, 
      consumers, practitioners, and healthcare providers. However, increased
      accessibility of PHR threatens the confidentiality, privacy, and security of
      personalized health information. Therefore, a need for robust and reliable forms 
      of authentication is of prime concern. The concept of biometric authentication is
      now highly visible to healthcare providers as a technology to prevent
      unauthorized access to individual health information. Implementing biometric
      authentication mechanisms to protect PHR facilitates access control and secure
      exchange of health information. In this paper, a literature review is used to
      explore the key benefits, technical barriers, challenges, and ethical
      implications for using biometric authentication in PHR.
FAU - Bonney, Wilfred
AU  - Bonney W
AD  - School of Business and Technology, Capella University, USA. bonney@cs.dal.ca
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Stud Health Technol Inform
JT  - Studies in health technology and informatics
JID - 9214582
MH  - *Biometry
MH  - Computer Security
MH  - Confidentiality
MH  - *Health Records, Personal/ethics
MH  - Systems Integration
MH  - United States
EDAT- 2011/02/22 06:00
MHDA- 2011/06/23 06:00
CRDT- 2011/02/22 06:00
PHST- 2011/02/22 06:00 [entrez]
PHST- 2011/02/22 06:00 [pubmed]
PHST- 2011/06/23 06:00 [medline]
PST - ppublish
SO  - Stud Health Technol Inform. 2011;164:110-6.


PMID- 21335592
OWN - NLM
STAT- MEDLINE
DCOM- 20110624
LR  - 20211020
IS  - 1740-7753 (Electronic)
IS  - 1740-7745 (Linking)
VI  - 8
IP  - 1
DP  - 2011 Feb
TI  - Fostering community understanding of sufficient benefit and early stopping for a 
      phase 2B HIV prevention clinical trial in Africa.
PG  - 103-11
LID - 10.1177/1740774510387170 [doi]
AB  - BACKGROUND: Most trials of interventions are designed to address the traditional 
      null hypothesis of no benefit. VOICE, a phase 2B HIV prevention trial funded by
      NIH and conducted in Africa, is designed to assess if the intervention will
      prevent a substantial fraction of infections. Planned interim analysis may
      provide conclusive evidence against the traditional null hypothesis without
      establishing substantial benefit. At this interim point, the Data and Safety
      Monitoring Board would then face the dilemma of knowing the product has some
      positive effect, but perhaps not as great an effect as the protocol has declared 
      necessary. PURPOSE: In March 2008, NIH program staff recommended that the VOICE
      protocol team discuss the stopping rules with stakeholders prior to initiating
      the protocol. The goals of the workshop were to inform community representatives 
      about the potential ethical dilemma associated with stopping rules and engage in 
      dialogue about these issues. We describe the resulting community consultation and
      summarize the outcomes. METHODS: A 2-day workshop was convened with the goal of
      having a clear and transparent consultation with the stakeholders around the
      question, 'Given emerging evidence that a product could prevent some infections, 
      would the community support a decision to continue accruing to the trial?'
      Participants included research staff and community stakeholders. Lectures with
      visual aids, discussions, and exercises using interactive learning tasks were
      used, with a focus on statistics and interpreting data from trials, particularly 
      interim data. RESULTS: Results of oral and written evaluations by participants
      were reviewed. The feedback was mostly positive, with some residual confusion
      regarding statistical concepts. However, discussions with attendees later
      revealed that not all felt prepared to engage fully in the workshop. LIMITATIONS:
      This was the presenters' first experience facilitating a formal discussion with
      an audience that had no advanced science, research, or mathematics training.
      Community representatives' concern regarding speaking for their communities
      without consulting them also created a challenge for the workshop. CONCLUSIONS:
      Open discussion around trial stopping rules requires that all discussants have an
      understanding of trial design concepts and feel a sense of empowerment to ask and
      answer questions. The VOICE CWG workshop was a first step toward the goal of open
      discussion regarding trial stopping rules and interim results for the study;
      however, ongoing education and dialogue must occur to ensure that all
      stakeholders fully participate in the process.
FAU - White, Rhonda
AU  - White R
AD  - FHI, Research Triangle Park, Durham, NC, USA. rwhite@fhi.org
FAU - Chileshe, Modesta
AU  - Chileshe M
FAU - Dawson, Liza
AU  - Dawson L
FAU - Donnell, Deborah
AU  - Donnell D
FAU - Hillier, Sharon
AU  - Hillier S
FAU - Morar, Neetha
AU  - Morar N
FAU - Noguchi, Lisa
AU  - Noguchi L
FAU - Dixon, Dennis
AU  - Dixon D
LA  - eng
GR  - U01 AI068633/AI/NIAID NIH HHS/United States
GR  - 5U01AI068633/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Trials
JT  - Clinical trials (London, England)
JID - 101197451
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - Africa
MH  - Anti-HIV Agents/therapeutic use
MH  - *Clinical Trials, Phase II as Topic
MH  - Early Termination of Clinical Trials/*psychology
MH  - Education
MH  - HIV Infections/drug therapy/*prevention & control
MH  - *Health Education
MH  - *Health Knowledge, Attitudes, Practice
MH  - Health Promotion
MH  - Humans
MH  - National Institutes of Health (U.S.)
MH  - Residence Characteristics
MH  - Social Marketing
MH  - Therapeutic Equipoise
MH  - Time
MH  - United States
PMC - PMC3478774
MID - NIHMS409269
EDAT- 2011/02/22 06:00
MHDA- 2011/06/28 06:00
CRDT- 2011/02/22 06:00
PHST- 2011/02/22 06:00 [entrez]
PHST- 2011/02/22 06:00 [pubmed]
PHST- 2011/06/28 06:00 [medline]
AID - 8/1/103 [pii]
AID - 10.1177/1740774510387170 [doi]
PST - ppublish
SO  - Clin Trials. 2011 Feb;8(1):103-11. doi: 10.1177/1740774510387170.


PMID- 21335572
OWN - NLM
STAT- MEDLINE
DCOM- 20110523
LR  - 20161125
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 4
DP  - 2011 Apr
TI  - Health and human rights: an area of neglect in the core curriculum?
PG  - 258-60
LID - 10.1136/jme.2010.037556 [doi]
AB  - Medical ethics and law education in the UK is undergoing continuous
      transformation. In parallel, human rights teaching with respect to health is
      expanding as a distinct field. Yet a resistance to the inclusion of human rights 
      in the medical ethics and law curriculum persists. In response to Stirrat and
      colleagues, this article seeks to highlight the mutual benefit that could be
      derived from an integration of human rights into the already established medical 
      ethics and law teaching in medical schools. It proposes that incorporating human 
      rights into the curriculum would add value to traditional medical ethics and law 
      teaching and provide a promising opportunity to enhance the interest from the
      student body.
FAU - Fitchett, Joseph Robert
AU  - Fitchett JR
AD  - Imperial College London, School of Public Health, Wright-Fleming Institute, St
      Mary's Hospital, 56 St Dunstan's Road, London W6 8RA, UK.
      joseph.fitchett@doctors.org.uk
FAU - Ferran, Elena
AU  - Ferran E
FAU - Footer, Katherine
AU  - Footer K
FAU - Ahmed, Natasha
AU  - Ahmed N
LA  - eng
PT  - Journal Article
DEP - 20110218
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Curriculum
MH  - Education, Medical, Undergraduate/*organization & administration/standards
MH  - Ethics, Medical/*education
MH  - Human Rights/*education
MH  - Humans
MH  - Schools, Medical/*organization & administration/standards
MH  - United Kingdom
EDAT- 2011/02/22 06:00
MHDA- 2011/05/24 06:00
CRDT- 2011/02/22 06:00
PHST- 2011/02/22 06:00 [entrez]
PHST- 2011/02/22 06:00 [pubmed]
PHST- 2011/05/24 06:00 [medline]
AID - jme.2010.037556 [pii]
AID - 10.1136/jme.2010.037556 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Apr;37(4):258-60. doi: 10.1136/jme.2010.037556. Epub 2011 Feb 
      18.


PMID- 21335362
OWN - NLM
STAT- MEDLINE
DCOM- 20110908
LR  - 20171116
IS  - 1461-7196 (Electronic)
IS  - 1363-4593 (Linking)
VI  - 15
IP  - 3
DP  - 2011 May
TI  - A way into empathy: a 'case' of photo-elicitation in illness research.
PG  - 259-75
LID - 10.1177/1363459310397976 [doi]
AB  - Brain injury patients often face a lack of empathy that leads to feelings of
      being disrespected and powerless. This article explores the use of
      photo-elicitation as one way to generate empathy in research (and clinical)
      relationships with acquired brain injury survivors through a re-examination of
      the process and products of photo-elicitation research conducted several years
      ago. The 'case' starkly illustrates the limits of researcher empathy and analysis
      even as the ethics of visual methods create opportunities for participants to
      share research power, contest research analyses, and present an alternate view
      that displays health and strength as well as illness. The 'case' prompts us to
      remain vigilant of the ways in which our personal lenses and histories affect
      what we see and shape our production of knowledge. Practicing empathy by using
      photos to create discursive spaces in research relationships may help us to learn
      about ourselves as we learn with patients.
FAU - Lorenz, Laura S
AU  - Lorenz LS
AD  - Institute for Behavioral Health, Heller School for Social Policy and Management, 
      Brandeis University, 415 South Street, Waltham, MA 01752, USA.
      llorenz@brandeis.edu
LA  - eng
PT  - Journal Article
DEP - 20110218
PL  - England
TA  - Health (London)
JT  - Health (London, England : 1997)
JID - 9800465
SB  - IM
MH  - Brain Injuries/*psychology
MH  - *Empathy
MH  - Humans
MH  - Interviews as Topic
MH  - Medicine in the Arts
MH  - New England
MH  - *Photography
MH  - *Professional-Patient Relations
MH  - Rehabilitation Centers
MH  - Research Design
EDAT- 2011/02/22 06:00
MHDA- 2011/09/09 06:00
CRDT- 2011/02/22 06:00
PHST- 2011/02/22 06:00 [entrez]
PHST- 2011/02/22 06:00 [pubmed]
PHST- 2011/09/09 06:00 [medline]
AID - 1363459310397976 [pii]
AID - 10.1177/1363459310397976 [doi]
PST - ppublish
SO  - Health (London). 2011 May;15(3):259-75. doi: 10.1177/1363459310397976. Epub 2011 
      Feb 18.


PMID- 21335154
OWN - NLM
STAT- MEDLINE
DCOM- 20110531
LR  - 20110221
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 43
IP  - 1
DP  - 2011 Jan-Feb
TI  - Secondary school teachers' assessment of the introduction of an educational
      program about organ donation and transplantation.
PG  - 58-60
LID - 10.1016/j.transproceed.2010.11.004 [doi]
AB  - INTRODUCTION: It is essential to provide information about organ donation and
      transplantation (ODT) to encourage school pupils to have favorable attitudes
      toward this matter in the future. The role of the teacher is crucial in this
      respect. The objective of this study was to determine acceptance by secondary
      school teachers of an educational program about ODT. MATERIALS AND METHODS: A
      random sample of secondary school teachers was taken from 10 secondary schools in
      the southeast of Spain. A total of 288 teachers were surveyed using a
      questionnaire that assessed the following; (1) acceptance of the educational
      program; (2) who should carry it out; and (3) some psychosocial variables related
      to ODT. RESULTS: Of the 288 secondary teachers surveyed, 283 of them responded to
      the acceptance of an educational program on ODT. Approximately half (54%) of the 
      respondents believed that it would be appropriate to introduce an educational
      program about ODT in secondary schools, 22% believed that there were currently
      other more important educational considerations, 20% had doubts, and 4% believed 
      that it would not be useful. The vast majority (71%) believed that a collaborator
      from the Regional Transplant Team would be the best person to carry out the
      program followed by any teacher (11%) or a teacher of ethics (9%). The remaining 
      9% were not sure. There was greater acceptance of an educational program about
      ODT among teachers who had a favorable attitude toward the matter (P = .003).
      CONCLUSIONS: An educational program about ODT in secondary education was not
      equally accepted by all teachers. Most teachers believed that the program should 
      be delivered by the Transplant Coordination Center rather than teachers
      themselves.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Rios, A
AU  - Rios A
AD  - International Collaborative Donor Project, and Transplant Unit, Hospital
      Universitario Virgen de la Arrixaca, Servicio Murciano de Salud, Murcia, Spain.
      ARZRIOS@teleline.es
FAU - Febrero, B
AU  - Febrero B
FAU - Lopez-Navas, A
AU  - Lopez-Navas A
FAU - Martinez-Alarcon, L
AU  - Martinez-Alarcon L
FAU - Sanchez, J
AU  - Sanchez J
FAU - Guzman, D
AU  - Guzman D
FAU - Ramis, G
AU  - Ramis G
FAU - Ramirez, P
AU  - Ramirez P
FAU - Parrilla, P
AU  - Parrilla P
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - *Faculty
MH  - Health Education/*methods
MH  - Humans
MH  - *Organ Transplantation
MH  - Spain
MH  - *Tissue and Organ Procurement
EDAT- 2011/02/22 06:00
MHDA- 2011/06/01 06:00
CRDT- 2011/02/22 06:00
PHST- 2011/02/22 06:00 [entrez]
PHST- 2011/02/22 06:00 [pubmed]
PHST- 2011/06/01 06:00 [medline]
AID - S0041-1345(10)01711-2 [pii]
AID - 10.1016/j.transproceed.2010.11.004 [doi]
PST - ppublish
SO  - Transplant Proc. 2011 Jan-Feb;43(1):58-60. doi:
      10.1016/j.transproceed.2010.11.004.


PMID- 21334689
OWN - NLM
STAT- MEDLINE
DCOM- 20110526
LR  - 20151119
IS  - 1527-3792 (Electronic)
IS  - 0022-5347 (Linking)
VI  - 185
IP  - 4
DP  - 2011 Apr
TI  - A survey of ethically challenging issues in urological practice.
PG  - 1407-11
LID - 10.1016/j.juro.2010.12.007 [doi]
AB  - PURPOSE: We surveyed ethical attitudes among urological and nonurological
      practitioners, allowing for thought and discussion regarding ethical issues in a 
      larger audience. MATERIALS AND METHODS: With input from an academic urologist, a 
      senior medical student and a hospital ethics committee member, a survey was
      created which asked for multiple choice responses to 3 demographic questions
      (practice type, age, location) and 10 ethically challenging clinical questions.
      Surveys were distributed online or via mail to 5 groups including academic
      urologists, urologists in private practice, medical students, hospital risk
      managers/attorneys and members of a bioethical society. Surveys were analyzed
      according to demographic variables. RESULTS: Surveys were sent out to 1,447
      individuals and 340 responses were received (24%). There were statistically
      significant differences in the responses to several questions based on practice
      type, age and practice location. There was a lack of consistency in answer
      choices with greater than 50% agreeing on a single answer choice for only 4 of 10
      questions (40%). CONCLUSIONS: This is the first study to our knowledge which
      attempts to objectively categorize ethical attitudes in a broad based survey of
      urologists and nonurologists, and challenges members of our profession to study
      their own responses to these ethical issues.
CI  - Copyright (c) 2011 American Urological Association Education and Research, Inc.
      Published by Elsevier Inc. All rights reserved.
FAU - Klausner, Adam P
AU  - Klausner AP
AD  - Virginia Commonwealth University Health System, Richmond, Virginia, USA.
      apklausner@vcu.edu
FAU - King, Ashley B
AU  - King AB
FAU - Velasquez, Monica
AU  - Velasquez M
FAU - Stike, Aaron B
AU  - Stike AB
FAU - Boone, Jacob
AU  - Boone J
FAU - Lyckholm, Laurel
AU  - Lyckholm L
FAU - Wolfe, Luke
AU  - Wolfe L
FAU - Koo, Harry P
AU  - Koo HP
LA  - eng
PT  - Journal Article
DEP - 20110222
PL  - United States
TA  - J Urol
JT  - The Journal of urology
JID - 0376374
SB  - IM
MH  - *Bioethical Issues
MH  - Humans
MH  - Practice Patterns, Physicians'/*ethics
MH  - Surveys and Questionnaires
MH  - Urology/*ethics
EDAT- 2011/02/22 06:00
MHDA- 2011/05/27 06:00
CRDT- 2011/02/22 06:00
PHST- 2010/08/11 00:00 [received]
PHST- 2011/02/22 06:00 [entrez]
PHST- 2011/02/22 06:00 [pubmed]
PHST- 2011/05/27 06:00 [medline]
AID - S0022-5347(10)05213-4 [pii]
AID - 10.1016/j.juro.2010.12.007 [doi]
PST - ppublish
SO  - J Urol. 2011 Apr;185(4):1407-11. doi: 10.1016/j.juro.2010.12.007. Epub 2011 Feb
      22.


PMID- 21334556
OWN - NLM
STAT- MEDLINE
DCOM- 20110705
LR  - 20110221
IS  - 1873-6513 (Electronic)
IS  - 0885-3924 (Linking)
VI  - 41
IP  - 2
DP  - 2011 Feb
TI  - Shades of truth: cultural and psychological factors affecting communication in
      pediatric palliative care.
PG  - 491-5
LID - 10.1016/j.jpainsymman.2010.12.002 [doi]
AB  - Communication with children who have life-threatening illnesses is a major
      challenge. Communication practices are greatly influenced by factors such as the 
      child's age, the parents' wishes, and the cultural norms. This article presents
      the case of a 12-year-old Japanese boy with advanced hepatoblastoma. The patient 
      also was diagnosed with Asperger's syndrome, which impairs interpersonal
      communication. The case is discussed from the perspective of clinical ethics,
      especially with regard to truth telling. The health care team faced an ethical
      dilemma because of the complications involved. Physicians treating children with 
      cancer should be aware of these issues to be able to effectively communicate with
      their patients.
CI  - Copyright (c) 2011 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. 
      All rights reserved.
FAU - Hatano, Yutaka
AU  - Hatano Y
AD  - Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural
      University of Medicine, Kawaramachi-Hirokoji, Kyoto, Japan.
      yhatano@koto.kpu-m.ac.jp
FAU - Yamada, Miwa
AU  - Yamada M
FAU - Fukui, Kenji
AU  - Fukui K
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Pain Symptom Manage
JT  - Journal of pain and symptom management
JID - 8605836
SB  - IM
MH  - Asperger Syndrome/*complications/psychology
MH  - Child
MH  - *Communication
MH  - Culture
MH  - Family/psychology
MH  - Hepatoblastoma/*complications/psychology/therapy
MH  - Humans
MH  - Liver Neoplasms/*complications/psychology/therapy
MH  - Male
MH  - Palliative Care/*ethics/psychology
MH  - Physician-Patient Relations/ethics
MH  - Professional-Family Relations/ethics
MH  - Truth Disclosure/*ethics
EDAT- 2011/02/22 06:00
MHDA- 2011/07/06 06:00
CRDT- 2011/02/22 06:00
PHST- 2010/08/16 00:00 [received]
PHST- 2010/11/13 00:00 [revised]
PHST- 2010/12/22 00:00 [accepted]
PHST- 2011/02/22 06:00 [entrez]
PHST- 2011/02/22 06:00 [pubmed]
PHST- 2011/07/06 06:00 [medline]
AID - S0885-3924(11)00009-1 [pii]
AID - 10.1016/j.jpainsymman.2010.12.002 [doi]
PST - ppublish
SO  - J Pain Symptom Manage. 2011 Feb;41(2):491-5. doi:
      10.1016/j.jpainsymman.2010.12.002.


PMID- 21334514
OWN - NLM
STAT- MEDLINE
DCOM- 20110803
LR  - 20140205
IS  - 1806-907X (Electronic)
IS  - 0034-7094 (Linking)
VI  - 61
IP  - 1
DP  - 2011 Jan-Feb
TI  - Bioethics and anesthesia: a reflexive study of reports published in the Brazilian
      Journal of Anesthesiology.
PG  - 121-7
LID - 10.1016/S0034-7094(11)70013-7 [doi]
AB  - BACKGROUND AND OBJECTIVES: There is a great lack of theoretical subsidies to
      guide ethical principles, specifically in the case of Anesthesiology. The
      objective of the present study was to analyze the bibliographic production
      regarding Bioethics in studies published by the Brazilian Journal of
      Anesthesiology between 1999 and 2009. METHODS: Three studies published between
      1999 and 2009 by the Brazilian Journal of Anesthesiology were selected. Those
      studies covered bioethical issues in Anesthesiology or correlated anesthesia and 
      Bioethics. A content analysis was used, according to the model of Bardin.
      RESULTS: It was observed that Bioethical ideals were the most predominant issue, 
      especially Principialism (f 23; 23.5%). On the other hand, the class that defines
      ethics as the cradle of Bioethics obtained the lowest amount of elementary
      context Units (CU) (f 15, 15.3%). CONCLUSIONS: In the studies mentioned,
      Bioethics is considered an ideal to be achieved, facing difficulties to be
      applied in daily Anesthesia practice. The need of studies that focus on
      anesthesia and Bioethics more specifically, reflecting problems regarding both
      subjects, should be emphasized.
CI  - Copyright (c) 2011 Elsevier Editora Ltda. All rights reserved.
FAU - Dos Santos, Maria de Fatima Oliveira
AU  - Dos Santos Mde F
AD  - Universidade do Porto, Portugal. fatimadeosantos@hotmail.com
FAU - de Franca, Genival Veloso
AU  - de Franca GV
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - Rev Bras Anestesiol
JT  - Revista brasileira de anestesiologia
JID - 0401316
SB  - IM
MH  - Anesthesia/*ethics
MH  - *Anesthesiology
MH  - Bibliometrics
MH  - *Bioethical Issues
MH  - Brazil
MH  - Humans
MH  - *Periodicals as Topic
MH  - *Publishing
EDAT- 2011/02/22 06:00
MHDA- 2011/08/04 06:00
CRDT- 2011/02/22 06:00
PHST- 2010/03/05 00:00 [received]
PHST- 2010/08/02 00:00 [accepted]
PHST- 2011/02/22 06:00 [entrez]
PHST- 2011/02/22 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
AID - S0034-7094(11)70013-7 [pii]
AID - 10.1016/S0034-7094(11)70013-7 [doi]
PST - ppublish
SO  - Rev Bras Anestesiol. 2011 Jan-Feb;61(1):121-7. doi:
      10.1016/S0034-7094(11)70013-7.


PMID- 21334018
OWN - NLM
STAT- MEDLINE
DCOM- 20110526
LR  - 20220309
IS  - 1527-3792 (Electronic)
IS  - 0022-5347 (Linking)
VI  - 185
IP  - 4
DP  - 2011 Apr
TI  - Focal therapy for localized prostate cancer: a phase I/II trial.
PG  - 1246-54
LID - 10.1016/j.juro.2010.11.079 [doi]
AB  - PURPOSE: Men with localized prostate cancer currently face a number of treatment 
      options that treat the entire prostate. These can cause significant sexual and
      urinary side effects. Focal therapy offers a novel strategy that targets the
      cancer rather than the prostate in an attempt to preserve tissue and function.
      MATERIALS AND METHODS: A prospective, ethics committee approved trial was
      conducted to determine the side effects of focal therapy using high intensity
      focused ultrasound. Multiparametric magnetic resonance imaging (T2-weighted,
      dynamic contrast enhanced, diffusion-weighted) and template transperineal
      prostate mapping biopsies were used to identify unilateral disease. Genitourinary
      side effects and quality of life outcomes were assessed using validated
      questionnaires. Posttreatment biopsies were performed at 6 months and followup
      was completed to 12 months. RESULTS: A total of 20 men underwent high intensity
      focused ultrasound hemiablation. Mean age was 60.4 years (SD 5.4, range 50 to 70)
      with mean prostate specific antigen 7.3 ng/ml (SD 2.8, range 3.4 to 11.8). Of the
      men 25% had low risk and 75% had intermediate risk cancer. Return of erections
      sufficient for penetrative sex occurred in 95% of men (19 of 20). In addition,
      90% of men (18 of 20) were pad-free, leak-free continent while 95% were pad-free.
      Mean prostate specific antigen decreased 80% to 1.5 ng/ml (SD 1.3) at 12 months. 
      Of the men 89% (17 of 19, 1 refused biopsy) had no histological evidence of any
      cancer, and none had histological evidence of high volume or Gleason 7 or greater
      cancer in the treated lobe. In addition, 89% of men achieved the trifecta status 
      of pad-free, leak-free continence, erections sufficient for intercourse and
      cancer control at 12 months. CONCLUSIONS: Our results appear sufficiently
      promising to support the further evaluation of focal therapy as a strategy to
      decrease some of the harms and costs associated with standard whole gland
      treatments.
CI  - Copyright (c) 2011 American Urological Association Education and Research, Inc.
      Published by Elsevier Inc. All rights reserved.
FAU - Ahmed, H U
AU  - Ahmed HU
AD  - Division of Surgery and Interventional Science, University College London,
      London, United Kingdom. hashim.ahmed@ucl.ac.uk
FAU - Freeman, A
AU  - Freeman A
FAU - Kirkham, A
AU  - Kirkham A
FAU - Sahu, M
AU  - Sahu M
FAU - Scott, R
AU  - Scott R
FAU - Allen, C
AU  - Allen C
FAU - Van der Meulen, J
AU  - Van der Meulen J
FAU - Emberton, M
AU  - Emberton M
LA  - eng
SI  - ClinicalTrials.gov/NCT00561262
SI  - ISRCTN/ISRCTN25145525
GR  - G0701302/MRC_/Medical Research Council/United Kingdom
GR  - G1002509/MRC_/Medical Research Council/United Kingdom
PT  - Clinical Trial, Phase I
PT  - Clinical Trial, Phase II
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110222
PL  - United States
TA  - J Urol
JT  - The Journal of urology
JID - 0376374
SB  - IM
CIN - J Urol. 2011 Apr;185(4):1254-5. PMID: 21334019
MH  - Aged
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Prostatic Neoplasms/*therapy
MH  - *Ultrasound, High-Intensity Focused, Transrectal
EDAT- 2011/02/22 06:00
MHDA- 2011/05/27 06:00
CRDT- 2011/02/22 06:00
PHST- 2010/08/30 00:00 [received]
PHST- 2011/02/22 06:00 [entrez]
PHST- 2011/02/22 06:00 [pubmed]
PHST- 2011/05/27 06:00 [medline]
AID - S0022-5347(10)05190-6 [pii]
AID - 10.1016/j.juro.2010.11.079 [doi]
PST - ppublish
SO  - J Urol. 2011 Apr;185(4):1246-54. doi: 10.1016/j.juro.2010.11.079. Epub 2011 Feb
      22.


PMID- 21333991
OWN - NLM
STAT- MEDLINE
DCOM- 20111118
LR  - 20140730
IS  - 1873-491X (Electronic)
IS  - 0020-7489 (Linking)
VI  - 48
IP  - 8
DP  - 2011 Aug
TI  - Development and psychometric testing of the Adaptive Capacity Index, an
      instrument to measure adaptive capacity in individuals with advanced cancer.
PG  - 986-94
LID - 10.1016/j.ijnurstu.2011.01.013 [doi]
AB  - BACKGROUND: We have proposed that declines in adaptive capacity, defined as the
      ability to adapt to multiple stressors, may serve as an indicator of risk for
      fatigue. A comprehensive measure of adaptive capacity does not exist. OBJECTIVES:
      In this paper we describe construction of an instrument to measure adaptive
      capacity, the Adaptive Capacity Index (ACI). DESIGN: Descriptive and
      psychometric. SETTING: Six sites providing palliative care in Western Canada.
      PARTICIPANTS: INCLUSION CRITERIA: >/=18 years old, diagnosed with advanced
      cancer, able to read and write English, Mini-Mental Status Exam score >/=22.
      Pilot study n=48; Main study n=225 stratified using the Edmonton Symptom
      Assessment Scale (ESAS) tiredness score (>/=0 to </=2 n=60; >/=3 to </=6 n=108;
      >/=7 and </=10 n=57). METHODS: Following ethics approval, 17 experts in symptom
      management assisted with content validation and consenting individuals completed 
      the Functional Assessment of Cancer Therapy-Fatigue (FACT-F), the Profile of Mood
      States-Vigor short form (POMS-Vsf), and the ACI. A research assistant collected
      demographic information and assigned an Eastern Cooperative Oncology Group (ECOG)
      score. Data were analyzed using descriptive and inferential statistics (i.e.,
      exploratory factor analyses, correlation, multivariate analyses of variance, and 
      multiple regression). RESULTS: Five 6-item ACI factors/subscales (Cognitive
      Function, Stamina/Muscle Endurance, Sleep Quality, Emotional Reactivity, and
      Social Interaction) were identified. The ACI-total scale and its subscales were
      internally consistent (Cronbach's alpha 0.76-0.89), and were significantly
      correlated with each other, and with each fatigue measure (Pearson's r ranging
      from -0.724 to 0.634). The ACI total score was sensitive to changes in the ESAS
      tiredness score. Stamina/Muscle Endurance, Cognitive Function, and Sleep Quality 
      predicted 60.8% of the variance in FACT-F. Stamina/Muscle Endurance and Social
      Interaction predicted 36.8% of the variance in POMS-Vsf. Stamina/Muscle Endurance
      and Sleep Quality predicted 8% of the variance in ECOG. CONCLUSIONS: The ACI is
      reliable and has beginning evidence of validity. In future studies we will
      examine relationships between ACI subscale scores and subsequent increases in
      fatigue and explore linkages to physiological processes. We will also establish
      ACI norms for early and late stage cancers and explore variations in ACI subscale
      scores base on age or gender.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Olson, K
AU  - Olson K
AD  - Faculty of Nursing, The University of Alberta, Edmonton, Alberta, Canada.
      Karin.Olson@ualberta.ca
FAU - Rogers, W T
AU  - Rogers WT
FAU - Cui, Y
AU  - Cui Y
FAU - Cree, M
AU  - Cree M
FAU - Baracos, V
AU  - Baracos V
FAU - Rust, T
AU  - Rust T
FAU - Mellott, I
AU  - Mellott I
FAU - Johnson, L
AU  - Johnson L
FAU - Macmillan, K
AU  - Macmillan K
FAU - Bonville, N
AU  - Bonville N
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20110218
PL  - England
TA  - Int J Nurs Stud
JT  - International journal of nursing studies
JID - 0400675
SB  - IM
MH  - *Adaptation, Psychological
MH  - Canada
MH  - Humans
MH  - Neoplasms/*psychology
MH  - *Psychometrics
EDAT- 2011/02/22 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/02/22 06:00
PHST- 2010/07/05 00:00 [received]
PHST- 2011/01/18 00:00 [revised]
PHST- 2011/01/22 00:00 [accepted]
PHST- 2011/02/22 06:00 [entrez]
PHST- 2011/02/22 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0020-7489(11)00033-2 [pii]
AID - 10.1016/j.ijnurstu.2011.01.013 [doi]
PST - ppublish
SO  - Int J Nurs Stud. 2011 Aug;48(8):986-94. doi: 10.1016/j.ijnurstu.2011.01.013. Epub
      2011 Feb 18.


PMID- 21333008
OWN - NLM
STAT- MEDLINE
DCOM- 20110707
LR  - 20211020
IS  - 1475-2891 (Electronic)
IS  - 1475-2891 (Linking)
VI  - 10
IP  - 1
DP  - 2011 Feb 18
TI  - Food for thought: an exploratory study of how physicians experience poor
      workplace nutrition.
PG  - 18
LID - 10.1186/1475-2891-10-18 [doi]
AB  - BACKGROUND: Nutrition is often a casualty of the busy work day for physicians. We
      aimed to explore physicians' views of their nutrition in the workplace including 
      their perceptions of the impact of inadequate nutrition upon their personal
      wellness and their professional performance. METHODS: This is a qualitative study
      of a sample of 20 physicians practicing in a large urban teaching hospital.
      Semi-structured open ended interviews were conducted to explore physicians' views
      of workplace nutrition. The same physicians had agreed to participate in a
      related nutrition based wellness intervention study that compared nutritional
      intake and cognitive function during a day of usual nutrition patterns against
      another day with scheduled nutrition breaks. A second set of interviews was
      conducted after the intervention study to explore how participation in the
      intervention impacted these views. Detailed interview content notes were
      transcribed and analyzed independently with differences reconciled by discussion.
      RESULTS: At initial interview, participants reported difficulty accessing
      adequate nutrition at work, linking this deficit with emotional (irritable and
      frustrated), physical (tired and hungry), and cognitive (difficulty concentrating
      and poor decision making) symptoms. In addition to identifying practical barriers
      such as lack of time to stop and eat, inconvenient access to food and poor food
      choices, the physicians described how their sense of professionalism and work
      ethic also hinder their work nutrition practices. After participating in the
      intervention, most physicians reported heightened awareness of their nutrition
      patterns and intentions to improve their workplace nutrition. CONCLUSIONS:
      Physicians report that inadequate workplace nutrition has a significant negative 
      impact on their personal wellness and professional performance. Given this threat
      to health care delivery, health care organizations and the medical profession
      need to address both the practical and professional barriers identified.
FAU - Lemaire, Jane B
AU  - Lemaire JB
AD  - Department of Medicine, Faculty of Medicine, University of Calgary, Health
      Sciences Center, 3330 University Drive NW, Calgary, AB, T2N 4N1, Canada.
      lemaire@ucalgary.ca
FAU - Wallace, Jean E
AU  - Wallace JE
FAU - Dinsmore, Kelly
AU  - Dinsmore K
FAU - Roberts, Delia
AU  - Roberts D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110218
PL  - England
TA  - Nutr J
JT  - Nutrition journal
JID - 101152213
SB  - IM
MH  - Adult
MH  - Cognition
MH  - Delivery of Health Care
MH  - *Energy Intake
MH  - *Feeding Behavior
MH  - Female
MH  - Food
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Middle Aged
MH  - Nutritional Status/*physiology
MH  - Physicians/*psychology
MH  - Professional Competence
MH  - *Surveys and Questionnaires
MH  - *Workplace
PMC - PMC3068081
EDAT- 2011/02/22 06:00
MHDA- 2011/07/08 06:00
CRDT- 2011/02/22 06:00
PHST- 2010/09/10 00:00 [received]
PHST- 2011/02/18 00:00 [accepted]
PHST- 2011/02/22 06:00 [entrez]
PHST- 2011/02/22 06:00 [pubmed]
PHST- 2011/07/08 06:00 [medline]
AID - 1475-2891-10-18 [pii]
AID - 10.1186/1475-2891-10-18 [doi]
PST - epublish
SO  - Nutr J. 2011 Feb 18;10(1):18. doi: 10.1186/1475-2891-10-18.


PMID- 21332933
OWN - NLM
STAT- MEDLINE
DCOM- 20110718
LR  - 20220330
IS  - 1526-4637 (Electronic)
IS  - 1526-2375 (Linking)
VI  - 12
IP  - 3
DP  - 2011 Mar
TI  - The role of the health insurance industry in perpetuating suboptimal pain
      management.
PG  - 415-26
LID - 10.1111/j.1526-4637.2011.01061.x [doi]
AB  - BACKGROUND: Unlike pain practitioners, health care insurers in the United States 
      are not expected to function according to a system of medical ethics. Rather,
      they are permitted to function under the business "ethic" of cost-containment and
      profitability. Despite calls for balancing the disparate agendas of stakeholders 
      in pain management in a pluralistic system, the health insurance industry has
      continued to fail to take the needs of suffering chronic pain patients into
      consideration in developing and enacting their policies that ultimately dictate
      the quality and quantity of pain management services available to enrollees. This
      essay examined these self-serving strategies, which include failure to reimburse 
      services and certain medications irrespective of their evidence-bases for
      clinical efficacy and cost-efficiency; "carving out" specific services from
      interdisciplinary treatment programs; and delaying and/or interrupting the
      provision of medically necessary treatment. Blatant and more subtle strategies
      utilized by insurers to achieve these ethically questionable goals are examined. 
      Additionally, this essay addressed some of the insurance industry's efforts to
      delegitimize chronic pain and its treatment as a whole. CONCLUSION: The author
      concludes that the outlook for chronic pain sufferers is not particularly bright,
      until such time that a not-for-profit single-payer system replaces the current
      treatment/reimbursement paradigm.
CI  - Wiley Periodicals, Inc.
FAU - Schatman, Michael E
AU  - Schatman ME
AD  - Foundation for Ethics in Pain Management, Bellevue, Washington 22203, USA.
      jgiordano@potomacinstitute.org
LA  - eng
PT  - Historical Article
PT  - Journal Article
DEP - 20110218
PL  - England
TA  - Pain Med
JT  - Pain medicine (Malden, Mass.)
JID - 100894201
SB  - IM
MH  - History, 18th Century
MH  - History, 19th Century
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - *Insurance, Health/economics/ethics/history
MH  - *Pain Management
MH  - Patients
MH  - Physicians
MH  - United States
EDAT- 2011/02/22 06:00
MHDA- 2011/07/19 06:00
CRDT- 2011/02/22 06:00
PHST- 2011/02/22 06:00 [entrez]
PHST- 2011/02/22 06:00 [pubmed]
PHST- 2011/07/19 06:00 [medline]
AID - 10.1111/j.1526-4637.2011.01061.x [doi]
PST - ppublish
SO  - Pain Med. 2011 Mar;12(3):415-26. doi: 10.1111/j.1526-4637.2011.01061.x. Epub 2011
      Feb 18.


PMID- 21332927
OWN - NLM
STAT- MEDLINE
DCOM- 20110718
LR  - 20141120
IS  - 1526-4637 (Electronic)
IS  - 1526-2375 (Linking)
VI  - 12
IP  - 3
DP  - 2011 Mar
TI  - The shifting architectonics of pain medicine: toward ethical realignment of
      scientific, medical and market values for the emerging global
      community--groundwork for policy.
PG  - 406-14
LID - 10.1111/j.1526-4637.2011.01055.x [doi]
AB  - Following the Second Industrial Revolution, Western medicine has become an
      interwoven enterprise of humanitarian and technologic values. In this essay, we
      posited that rather than being seen as a means toward achieving the ends of
      providing technically right and morally sound pain care, the resources and goods 
      of pain medicine have been subordinated to a market-based values system that
      regards these tools as ends unto themselves. We argued that this approach is 1)
      pragmatically inapt, in that it fails to acknowledge and provide those tools as
      rightly necessary for the "good" of pain medicine to be enacted; and is therefore
      2) morally unsound, in that the good, while recognized, is not afforded, thereby 
      disserving the fiduciary of science/technology, medicine, and economics. We
      framed these issues within 1) the context(s) and effects of postmodernism and 2) 
      the increasing call for a globally relevant and applicable system of pain care.
      Toward this latter end, we addressed how policies can be created that accommodate
      differing social values, and still enable the execution of care in ways that are 
      morally sound, yet economically viable. We posited that such policies need to be 
      finely grained so as to 1) sustain research in pain diagnosis, assessment,
      treatment, and management; 2) translate research efforts into clinically relevant
      resources; 3) enable availability and just distribution of both low- and
      high-tech resources; and 4) prompt fiscal programs that support, allow, and
      reinforce responsible choice (of such resources) as socioculturally required,
      valued, and valid.
CI  - Wiley Periodicals, Inc.
FAU - Giordano, James
AU  - Giordano J
AD  - Center for Neurotechnology Studies, Potomac Institute for Policy Studies,
      Arlington, Virginia 22203, USA. jgiordano@potomacinstitute.org
FAU - Benedikter, Roland
AU  - Benedikter R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110218
PL  - England
TA  - Pain Med
JT  - Pain medicine (Malden, Mass.)
JID - 100894201
SB  - IM
MH  - Culture
MH  - *Ethics, Medical
MH  - Global Health
MH  - Health Services Accessibility
MH  - Humans
MH  - *Medicine
MH  - Pain/*economics/psychology
MH  - *Pain Management
MH  - *Policy
MH  - Postmodernism
MH  - *Residence Characteristics
MH  - Social Values
EDAT- 2011/02/22 06:00
MHDA- 2011/07/19 06:00
CRDT- 2011/02/22 06:00
PHST- 2011/02/22 06:00 [entrez]
PHST- 2011/02/22 06:00 [pubmed]
PHST- 2011/07/19 06:00 [medline]
AID - 10.1111/j.1526-4637.2011.01055.x [doi]
PST - ppublish
SO  - Pain Med. 2011 Mar;12(3):406-14. doi: 10.1111/j.1526-4637.2011.01055.x. Epub 2011
      Feb 18.


PMID- 21332831
OWN - NLM
STAT- MEDLINE
DCOM- 20120207
LR  - 20211203
IS  - 1365-277X (Electronic)
IS  - 0952-3871 (Linking)
VI  - 24
IP  - 2
DP  - 2011 Apr
TI  - A qualitative study of cardiac rehabilitation patients' perspectives on making
      dietary changes.
PG  - 122-7
LID - 10.1111/j.1365-277X.2010.01136.x [doi]
AB  - BACKGROUND: Making healthier food choices is recognised as being important in the
      secondary prevention of coronary heart disease (CHD) and the provision of
      information about making dietary changes should be included in cardiac
      rehabilitation (CR), a secondary prevention strategy. Studies indicate that
      patients do not always make the recommended dietary changes, although research on
      CR patients' perspectives on dietary change appears to be limited. The present
      study aimed to explore CR patients' perspectives on making and maintaining
      dietary changes. METHODS: Following ethical approval, in-depth, audiotaped,
      qualitative interviews were conducted with 15 post-myocardial infarction CR
      patients (11 men and four women) who had completed a hospital-based CR programme.
      Participants comprised White British individuals aged 42-65 years, from a variety
      of socioeconomic backgrounds. Interview topics included perspectives on CHD and
      lifestyle changes, including diet. Follow-up interviews with 10 patients,
      conducted approximately 9 months later, explored whether their perspectives had
      changed. RESULTS: Patients tended to only make and maintain dietary changes if
      they perceived their diet to be a cause of their CHD. The only dietary changes
      patients reported involved 'cutting things out' of their diet; patients did not
      make dietary changes if they considered that they did not need to 'cut things
      out'. CONCLUSIONS: These findings suggest that, despite receiving information
      about eating a balanced diet, CR patients may perceive dietary change in terms of
      whether or not they need to 'cut things out' of their diet. Greater emphasis may 
      be needed in dietary information on increasing the proportion of healthy foods
      consumed and choosing healthier alternatives.
CI  - (c) 2011 The Authors. Journal compilation (c) 2011 The British Dietetic
      Association Ltd.
FAU - White, S
AU  - White S
AD  - Division of Social Research in Medicines and Health, School of Pharmacy,
      University of Nottingham, Nottingham, UK. s.j.white@mema.keele.ac.uk
FAU - Bissell, P
AU  - Bissell P
FAU - Anderson, C
AU  - Anderson C
LA  - eng
PT  - Journal Article
DEP - 20110221
PL  - England
TA  - J Hum Nutr Diet
JT  - Journal of human nutrition and dietetics : the official journal of the British
      Dietetic Association
JID - 8904840
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Attitude to Health
MH  - Coronary Disease/*diet therapy
MH  - *Diet
MH  - *Feeding Behavior
MH  - Female
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*prevention & control/rehabilitation
MH  - Perception
MH  - Qualitative Research
MH  - *Secondary Prevention
MH  - United Kingdom
MH  - Whites
EDAT- 2011/02/22 06:00
MHDA- 2012/02/09 06:00
CRDT- 2011/02/22 06:00
PHST- 2011/02/22 06:00 [entrez]
PHST- 2011/02/22 06:00 [pubmed]
PHST- 2012/02/09 06:00 [medline]
AID - 10.1111/j.1365-277X.2010.01136.x [doi]
PST - ppublish
SO  - J Hum Nutr Diet. 2011 Apr;24(2):122-7. doi: 10.1111/j.1365-277X.2010.01136.x.
      Epub 2011 Feb 21.


PMID- 21332501
OWN - NLM
STAT- MEDLINE
DCOM- 20110418
LR  - 20110221
IS  - 1749-6632 (Electronic)
IS  - 0077-8923 (Linking)
VI  - 1219
DP  - 2011 Feb
TI  - What should we call instruments commonly known as payments for environmental
      services? A review of the literature and a proposal.
PG  - 209-25
LID - 10.1111/j.1749-6632.2010.05941.x [doi]
AB  - Researchers, policy makers, and practitioners have used various terms to describe
      instruments that reward the stewardship of ecosystem services that benefit
      "external" actors. Payments for environmental services, or PES, has been the
      predominant name. However, critics have challenged both the payments and
      environmental components of this nomenclature, most commonly proposing markets,
      compensation, or rewards as alternatives for the former, and ecosystem for the
      latter. Additional questions arise regarding what to call the agents directly
      involved in the transaction: sellers and buyers, or stewards and beneficiaries?
      For some, concerns about this terminology have emerged from so-called "pro-poor
      PES" debates that ask if actors could and should incorporate poverty alleviation 
      goals into PES instruments. This review of the modulating use of terms and the
      arguments about which best fit theory and experience points to the key policy and
      ethical issues at stake as PES programs face critical and timely questions about 
      the direction they will head. The author contends that the choices of terms will 
      influence that direction and proposes a new alternative-rewards for ecosystem
      service stewardship (RESS)-that better encompasses pro-poor options.
CI  - (c) 2011 New York Academy of Sciences.
FAU - Shelley, Barry G
AU  - Shelley BG
AD  - Graduate Programs in Sustainable International Development, The Heller School for
      Social Policy and Management, Brandeis University, Waltham, Massachusetts, USA.
      bshelley@brandeis.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
SB  - IM
MH  - *Ecosystem
MH  - *Environment
EDAT- 2011/02/22 06:00
MHDA- 2011/04/19 06:00
CRDT- 2011/02/22 06:00
PHST- 2011/02/22 06:00 [entrez]
PHST- 2011/02/22 06:00 [pubmed]
PHST- 2011/04/19 06:00 [medline]
AID - 10.1111/j.1749-6632.2010.05941.x [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2011 Feb;1219:209-25. doi: 10.1111/j.1749-6632.2010.05941.x.


PMID- 21332250
OWN - NLM
STAT- MEDLINE
DCOM- 20110715
LR  - 20110221
IS  - 1179-1896 (Electronic)
IS  - 1175-5652 (Linking)
VI  - 9
IP  - 2
DP  - 2011 Mar 1
TI  - Germany's decision rule for setting ceiling prices of drugs: a comparative
      analysis with other decision rules.
PG  - 65-71
LID - 10.2165/11586640-000000000-00000 [doi]
AB  - In Germany, the Institute for Quality and Efficiency in Health Care (IQWiG) makes
      recommendations for ceiling prices of drugs based on an evaluation of the
      relationship between costs and effectiveness. To set ceiling prices, IQWiG uses
      the following decision rule: the incremental cost-effectiveness ratio (ICER) of a
      new drug compared with the next effective intervention should not be higher than 
      that of the next effective intervention compared with its comparator. The purpose
      of this article is to analyse ethical implications of IQWiG's rule and compare
      them with those of two alternative decision rules, one that is based on an
      absolute cost-effectiveness threshold and one that falls in between. To this end,
      constrained optimization problems are defined that yield each decision rule. This
      article shows that IQWiG's rule accounts for severity of disease and past
      resource consumption. Potential problems and pitfalls are discussed.
FAU - Gandjour, Afschin
AU  - Gandjour A
AD  - Louisiana State University, Pennington Biomedical Research Center, Baton Rouge,
      LA 70808, USA. afschin.gandjour@pbrc.edu
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - New Zealand
TA  - Appl Health Econ Health Policy
JT  - Applied health economics and health policy
JID - 101150314
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - *Advisory Committees/ethics/organization & administration
MH  - *Bioethical Issues
MH  - Cost-Benefit Analysis
MH  - *Decision Making, Organizational
MH  - Germany
MH  - Humans
MH  - Insurance, Health, Reimbursement
MH  - Pharmaceutical Preparations/*economics
MH  - Quality Assurance, Health Care/ethics/*organization & administration
EDAT- 2011/02/22 06:00
MHDA- 2011/07/16 06:00
CRDT- 2011/02/22 06:00
PHST- 2011/02/22 06:00 [entrez]
PHST- 2011/02/22 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
AID - 1 [pii]
AID - 10.2165/11586640-000000000-00000 [doi]
PST - ppublish
SO  - Appl Health Econ Health Policy. 2011 Mar 1;9(2):65-71. doi:
      10.2165/11586640-000000000-00000.


PMID- 21330895
OWN - NLM
STAT- MEDLINE
DCOM- 20110606
LR  - 20110218
IS  - 1538-9855 (Electronic)
IS  - 0363-3624 (Linking)
VI  - 36
IP  - 2
DP  - 2011 Mar-Apr
TI  - The mock trial: a collaborative interdisciplinary approach to understanding legal
      and ethical issues.
PG  - 66-9
LID - 10.1097/NNE.0b013e31820b5029 [doi]
AB  - To provide high-quality, safe, patient-centered care, RNs must exhibit a strong
      understanding of legal and ethical issues. The authors describe an
      interdisciplinary teaching learning strategy, the premock, actual, and postmock
      trial, to augment student retention of legal and ethical concepts and enhance the
      development of their personal accountability.
FAU - March, Alice L
AU  - March AL
AD  - The University of Alabama, Capstone College of Nursing, Tuscaloosa, AL, USA.
      almarch@bama.ua.edu
FAU - Ford, Cassandra D
AU  - Ford CD
FAU - Adams, Marsha Howell
AU  - Adams MH
FAU - Cheshire, Michelle
AU  - Cheshire M
FAU - Collins, Angela S
AU  - Collins AS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Nurse Educ
JT  - Nurse educator
JID - 7701902
MH  - *Cooperative Behavior
MH  - Education, Medical/*legislation & jurisprudence
MH  - Education, Nursing/*legislation & jurisprudence
MH  - Faculty, Nursing
MH  - Humans
MH  - *Learning
MH  - Liability, Legal
MH  - Nursing Research
MH  - Patient Care Team/*legislation & jurisprudence
MH  - Patient-Centered Care/ethics/legislation & jurisprudence
MH  - Quality of Health Care/ethics/legislation & jurisprudence
MH  - Social Responsibility
MH  - Students, Nursing
MH  - Teaching/*methods
MH  - United States
EDAT- 2011/02/19 06:00
MHDA- 2011/06/07 06:00
CRDT- 2011/02/19 06:00
PHST- 2011/02/19 06:00 [entrez]
PHST- 2011/02/19 06:00 [pubmed]
PHST- 2011/06/07 06:00 [medline]
AID - 10.1097/NNE.0b013e31820b5029 [doi]
AID - 00006223-201103000-00012 [pii]
PST - ppublish
SO  - Nurse Educ. 2011 Mar-Apr;36(2):66-9. doi: 10.1097/NNE.0b013e31820b5029.


PMID- 21330567
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 259
IP  - 2
DP  - 2011 May
TI  - Obstetric brachial plexus lesions: CT myelography.
PG  - 508-15
LID - 10.1148/radiol.10101417 [doi]
AB  - PURPOSE: To evaluate the value of computed tomographic (CT) myelography in the
      detection of root damage and differentiation of root avulsions from neurotmesis
      in a large cohort of patients with an obstetric brachial plexus lesion (OBPL).
      MATERIALS AND METHODS: Institutional review board approval was obtained. Informed
      consent was waived by the medical ethics committee. One hundred eighteen patients
      with OBPL born in the cephalic position and six patients born in the breech
      position were selected for surgery by two neurosurgeons in a multidisciplinary
      team. Functional loss of the C5 through T1 innervated muscles was noted. All
      patients underwent preoperative CT myelography at an average age of 19 weeks. CT 
      myelographic examination results were reviewed by two radiologists, who were
      blinded to the clinical findings, for the presence of root avulsions and
      pseudocysts. Interobserver agreement was assessed by calculating kappa values.
      RESULTS: CT myelographic results showed root avulsions in at least one level in
      66 (56%) of 118 patients born in the cephalic position and in six (100%) of six
      patients born in the breech position. Levels C7 and C8 showed the most root
      avulsions, even if not expected from clinical examination results. A large number
      of root avulsions showed pseudocysts (73 [68%] of 107 levels in patients born in 
      the cephalic position and 11 [73%] of 15 levels in patients born in the breech
      position). CONCLUSION: CT myelographic results showed root avulsions in more than
      half of patients with OBPL. Root avulsions were even detected at levels that were
      not expected at clinical examination. Because root avulsions require specific
      reconstructive techniques, CT myelography is recommended for every preoperative
      patient with OBPL.
CI  - RSNA, 2011
FAU - Steens, Stefan C A
AU  - Steens SC
AD  - Department of Radiology, Leiden University Medical Center, C2S, PO Box 9600, 2300
      RC Leiden, The Netherlands. s.steens@rad.umcn.nl
FAU - Pondaag, Willem
AU  - Pondaag W
FAU - Malessy, Martijn J A
AU  - Malessy MJ
FAU - Verbist, Berit M
AU  - Verbist BM
LA  - eng
PT  - Journal Article
DEP - 20110217
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Birth Injuries/*diagnostic imaging
MH  - Brachial Plexus/*diagnostic imaging/*injuries
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Myelography/*methods
MH  - Retrospective Studies
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2011/02/19 06:00
MHDA- 2011/07/27 06:00
CRDT- 2011/02/19 06:00
PHST- 2011/02/19 06:00 [entrez]
PHST- 2011/02/19 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
AID - radiol.10101417 [pii]
AID - 10.1148/radiol.10101417 [doi]
PST - ppublish
SO  - Radiology. 2011 May;259(2):508-15. doi: 10.1148/radiol.10101417. Epub 2011 Feb
      17.


PMID- 21330557
OWN - NLM
STAT- MEDLINE
DCOM- 20110527
LR  - 20220310
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 259
IP  - 1
DP  - 2011 Apr
TI  - Hepatic resection versus transarterial lipiodol chemoembolization as the initial 
      treatment for large, multiple, and resectable hepatocellular carcinomas: a
      prospective nonrandomized analysis.
PG  - 286-95
LID - 10.1148/radiol.10101072 [doi]
AB  - PURPOSE: To compare the survival outcomes between hepatic resection and
      transarterial lipiodol chemoembolization (TACE) used as the initial treatment in 
      patients with large (>/=5 cm), multiple, and resectable hepatocellular
      carcinomas. MATERIALS AND METHODS: This study had local ethical committee
      approval; all patients gave written informed consent. Between January 2004 and
      December 2006, 168 consecutive patients were prospectively studied. As an initial
      treatment, 85 patients underwent hepatic resection and 83 underwent TACE. Of the 
      29 of 83 patients in whom there was a good response to TACE, 13 underwent
      subsequent hepatic resection. The remaining 16 patients, who refused hepatic
      resection, underwent TACE and local ablation. Repeated TACE was performed in
      patients with stable disease or progressive disease after initial TACE. The
      differences in survival between groups and subgroups were calculated with the
      Kaplan-Meier method. Univariate and multivariate analyses were performed to
      clarify the prognostic factors for survival. RESULTS: The 1-, 3-, and 5-year
      overall survival rates for the initial hepatic resection group and the initial
      TACE group were 70.6%, 35.3%, 23.9% and 67.2%, 26.0%, 18.9%, respectively (P =
      .26). Complication rates were significantly higher in the initial hepatic
      resection group than in the initial TACE group (P < .01). The 1-, 3-, and 5-year 
      overall survival rates in patients who underwent initial TACE and subsequent
      hepatic resection were 92.3%, 67.3%, and 50.5%, respectively, which were
      significantly higher than rates in patients treated with initial hepatic
      resection (P = .04) but were not significantly higher than in patients who
      responded well to TACE but refused hepatic resection (P = .07). Tumor size was
      the independent risk factor for survival. CONCLUSION: TACE might be a better
      initial treatment in patients with large, multiple, and resectable hepatocellular
      carcinomas; hepatic resection should be recommended to patients who respond well 
      to TACE.
CI  - (c) RSNA, 2011.
FAU - Luo, Jun
AU  - Luo J
AD  - Department of Hepatobiliary Oncology, Cancer Center, Sun Yat-sen University, 651 
      Dongfeng Road East, Guangzhou 510060, P.R. China.
FAU - Peng, Zhen-Wei
AU  - Peng ZW
FAU - Guo, Rong-Ping
AU  - Guo RP
FAU - Zhang, Ya-Qi
AU  - Zhang YQ
FAU - Li, Jin-Qing
AU  - Li JQ
FAU - Chen, Min-Shan
AU  - Chen MS
FAU - Shi, Ming
AU  - Shi M
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110217
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Hemostatics)
RN  - 8008-53-5 (Ethiodized Oil)
SB  - IM
MH  - Carcinoma, Hepatocellular/diagnosis/*mortality/*therapy
MH  - Chemoembolization, Therapeutic/*statistics & numerical data
MH  - China/epidemiology
MH  - Ethiodized Oil/*administration & dosage
MH  - Female
MH  - Hemostatics/administration & dosage
MH  - Hepatectomy/*statistics & numerical data
MH  - Humans
MH  - Injections, Intra-Arterial
MH  - Liver Neoplasms/diagnosis/*mortality/*therapy
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Prognosis
MH  - Prospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Survival Analysis
MH  - Survival Rate
MH  - Treatment Outcome
EDAT- 2011/02/19 06:00
MHDA- 2011/05/28 06:00
CRDT- 2011/02/19 06:00
PHST- 2011/02/19 06:00 [entrez]
PHST- 2011/02/19 06:00 [pubmed]
PHST- 2011/05/28 06:00 [medline]
AID - radiol.10101072 [pii]
AID - 10.1148/radiol.10101072 [doi]
PST - ppublish
SO  - Radiology. 2011 Apr;259(1):286-95. doi: 10.1148/radiol.10101072. Epub 2011 Feb
      17.


PMID- 21330505
OWN - NLM
STAT- MEDLINE
DCOM- 20110308
LR  - 20110218
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Linking)
VI  - 331
IP  - 6019
DP  - 2011 Feb 18
TI  - Emerging forensics field may hit legal, ethical obstacles.
PG  - 840
LID - 10.1126/science.331.6019.840 [doi]
FAU - Enserink, Martin
AU  - Enserink M
LA  - eng
PT  - News
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
SB  - IM
MH  - Biometric Identification/*ethics
MH  - DNA Fingerprinting
MH  - Europe
MH  - Forensic Genetics/*ethics/*legislation & jurisprudence/methods
MH  - Genetic Privacy
MH  - Humans
MH  - *Phenotype
MH  - United States
EDAT- 2011/02/19 06:00
MHDA- 2011/03/09 06:00
CRDT- 2011/02/19 06:00
PHST- 2011/02/19 06:00 [entrez]
PHST- 2011/02/19 06:00 [pubmed]
PHST- 2011/03/09 06:00 [medline]
AID - 331/6019/840 [pii]
AID - 10.1126/science.331.6019.840 [doi]
PST - ppublish
SO  - Science. 2011 Feb 18;331(6019):840. doi: 10.1126/science.331.6019.840.


PMID- 21329524
OWN - NLM
STAT- MEDLINE
DCOM- 20110714
LR  - 20220408
IS  - 1471-2296 (Electronic)
IS  - 1471-2296 (Linking)
VI  - 12
DP  - 2011 Feb 17
TI  - Genetic educational needs and the role of genetics in primary care: a focus group
      study with multiple perspectives.
PG  - 5
LID - 10.1186/1471-2296-12-5 [doi]
AB  - BACKGROUND: Available evidence suggests that improvements in genetics education
      are needed to prepare primary care providers for the impact of ongoing rapid
      advances in genomics. Postgraduate (physician training) and master (midwifery
      training) programmes in primary care and public health are failing to meet these 
      perceived educational needs. The aim of this study was to explore the role of
      genetics in primary care (i.e. family medicine and midwifery care) and the need
      for education in this area as perceived by primary care providers, patient
      advocacy groups and clinical genetics professionals. METHODS: Forty-four
      participants took part in three types of focus groups: mono-disciplinary groups
      of general practitioners and midwives, respectively and multidisciplinary groups 
      composed of a diverse set of experts. The focus group sessions were audio-taped, 
      transcribed verbatim and analysed using content analysis. Recurrent themes were
      identified. RESULTS: Four themes emerged regarding the educational needs and the 
      role of genetics in primary care: (1) genetics knowledge, (2) family history, (3)
      ethical dilemmas and psychosocial effects in relation to genetics and (4) insight
      into the organisation and role of clinical genetics services. These themes
      reflect a shift in the role of genetics in primary care with implications for
      education. Although all focus group participants acknowledged the importance of
      genetics education, general practitioners felt this need more urgently than
      midwives and more strongly emphasized their perceived knowledge deficiencies.
      CONCLUSION: The responsibilities of primary care providers with regard to
      genetics require further study. The results of this study will help to develop
      effective genetics education strategies to improve primary care providers'
      competencies in this area. More research into the educational priorities in
      genetics is needed to design courses that are suitable for postgraduate and
      master programmes for general practitioners and midwives.
FAU - Houwink, Elisa Jf
AU  - Houwink EJ
AD  - Department of Clinical Genetics, EMGO Institute for Health and Care Research, VU 
      University Medical Center, Amsterdam, The Netherlands. e.houwink@vumc.nl
FAU - van Luijk, Scheltus J
AU  - van Luijk SJ
FAU - Henneman, Lidewij
AU  - Henneman L
FAU - van der Vleuten, Cees
AU  - van der Vleuten C
FAU - Jan Dinant, Geert
AU  - Jan Dinant G
FAU - Cornel, Martina C
AU  - Cornel MC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110217
PL  - England
TA  - BMC Fam Pract
JT  - BMC family practice
JID - 100967792
SB  - IM
MH  - Adult
MH  - Education, Medical, Graduate/*methods
MH  - Evaluation Studies as Topic
MH  - Female
MH  - Focus Groups
MH  - Genetic Predisposition to Disease
MH  - Genetics/*education
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Midwifery/*education
MH  - *Needs Assessment
MH  - Physicians, Primary Care/*education
MH  - Primary Health Care
MH  - Young Adult
PMC - PMC3053218
EDAT- 2011/02/19 06:00
MHDA- 2011/07/16 06:00
CRDT- 2011/02/19 06:00
PHST- 2010/08/11 00:00 [received]
PHST- 2011/02/17 00:00 [accepted]
PHST- 2011/02/19 06:00 [entrez]
PHST- 2011/02/19 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
AID - 1471-2296-12-5 [pii]
AID - 10.1186/1471-2296-12-5 [doi]
PST - epublish
SO  - BMC Fam Pract. 2011 Feb 17;12:5. doi: 10.1186/1471-2296-12-5.


PMID- 21329498
OWN - NLM
STAT- MEDLINE
DCOM- 20110610
LR  - 20211020
IS  - 1471-2288 (Electronic)
IS  - 1471-2288 (Linking)
VI  - 11
DP  - 2011 Feb 17
TI  - Methodological issues associated with collecting sensitive information over the
      telephone--experience from an Australian non-suicidal self-injury (NSSI)
      prevalence study.
PG  - 20
LID - 10.1186/1471-2288-11-20 [doi]
AB  - BACKGROUND: Collecting population data on sensitive issues such as non-suicidal
      self-injury (NSSI) is problematic. Case note audits or hospital/clinic based
      presentations only record severe cases and do not distinguish between suicidal
      and non-suicidal intent. Community surveys have largely been limited to school
      and university students, resulting in little much needed population-based data on
      NSSI. Collecting these data via a large scale population survey presents
      challenges to survey methodologists. This paper addresses the methodological
      issues associated with collecting this type of data via CATI. METHODS: An
      Australia-wide population survey was funded by the Australian Government to
      determine prevalence estimates of NSSI and associations, predictors,
      relationships to suicide attempts and suicide ideation, and outcomes. Computer
      assisted telephone interviewing (CATI) on a random sample of the Australian
      population aged 10+ years of age from randomly selected households, was
      undertaken. RESULTS: Overall, from 31,216 eligible households, 12,006 interviews 
      were undertaken (response rate 38.5%). The 4-week prevalence of NSSI was 1.1%
      (95% ci 0.9-1.3%) and lifetime prevalence was 8.1% (95% ci
      7.6-8.6).Methodological concerns and challenges in regard to collection of these 
      data included extensive interviewer training and post interview counselling.
      Ethical considerations, especially with children as young as 10 years of age
      being asked sensitive questions, were addressed prior to data collection. The
      solution required a large amount of information to be sent to each selected
      household prior to the telephone interview which contributed to a lower than
      expected response rate. Non-coverage error caused by the population of interest
      being highly mobile, homeless or institutionalised was also a suspected issue in 
      this low prevalence condition. In many circumstances the numbers missing from the
      sampling frame are small enough to not cause worry, especially when compared with
      the population as a whole, but within the population of interest to us, we
      believe that the most likely direction of bias is towards an underestimation of
      our prevalence estimates. CONCLUSION: Collecting valid and reliable data is a
      paramount concern of health researchers and survey research methodologists. The
      challenge is to design cost-effective studies especially those associated with
      low-prevalence issues, and to balance time and convenience against validity,
      reliability, sampling, coverage, non-response and measurement error issues.
FAU - Taylor, Anne W
AU  - Taylor AW
AD  - Population Research and Outcome Studies, School of Medicine, University of
      Adelaide, Adelaide (5000), Australia. anne.taylor@adelaide.edu.au
FAU - Martin, Graham
AU  - Martin G
FAU - Dal Grande, Eleonora
AU  - Dal Grande E
FAU - Swannell, Sarah
AU  - Swannell S
FAU - Fullerton, Simon
AU  - Fullerton S
FAU - Hazell, Philip
AU  - Hazell P
FAU - Harrison, James E
AU  - Harrison JE
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20110217
PL  - England
TA  - BMC Med Res Methodol
JT  - BMC medical research methodology
JID - 100968545
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Australia
MH  - Child
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Interviews as Topic/*methods
MH  - Male
MH  - Middle Aged
MH  - Population Surveillance/*methods
MH  - Self-Injurious Behavior/epidemiology
MH  - *Truth Disclosure
MH  - Young Adult
PMC - PMC3049141
EDAT- 2011/02/19 06:00
MHDA- 2011/06/11 06:00
CRDT- 2011/02/19 06:00
PHST- 2010/08/02 00:00 [received]
PHST- 2011/02/17 00:00 [accepted]
PHST- 2011/02/19 06:00 [entrez]
PHST- 2011/02/19 06:00 [pubmed]
PHST- 2011/06/11 06:00 [medline]
AID - 1471-2288-11-20 [pii]
AID - 10.1186/1471-2288-11-20 [doi]
PST - epublish
SO  - BMC Med Res Methodol. 2011 Feb 17;11:20. doi: 10.1186/1471-2288-11-20.


PMID- 21329426
OWN - NLM
STAT- MEDLINE
DCOM- 20110525
LR  - 20110218
IS  - 1744-8387 (Electronic)
IS  - 1478-9450 (Linking)
VI  - 8
IP  - 1
DP  - 2011 Feb
TI  - Defining pluripotent stem cells through quantitative proteomic analysis.
PG  - 29-42
LID - 10.1586/epr.10.100 [doi]
AB  - Embryonic stem cells (ESCs) are at the center stage of intense research, inspired
      by their potential to give rise to all cell types of the adult individual. This
      property makes ESCs suitable candidates for generating specialized cells to
      replace damaged tissue lost after injury or disease. However, such clinical
      applications require a detailed insight of the molecular mechanisms underlying
      the self-renewal, expansion and differentiation of stem cells. This has gained
      further relevance since the introduction of induced pluripotent stem cells
      (iPSCs), which are functionally very similar to ESCs. The key property that iPSCs
      can be derived from somatic cells lifts some of the major ethical issues related 
      to the need for embryos to generate ESCs. Yet, this has only increased the need
      to define the similarity of iPSCs and ESCs at the molecular level, both before
      and after they are induced to differentiate. In this article, we describe the
      proteomic approaches that have been used to characterize ESCs with regard to
      self-renewal and differentiation, with an emphasis on signaling cascades and
      histone modifications. We take this as a lead to discuss how quantitative
      proteomics can be deployed to study reprogramming and iPSC identity. In addition,
      we discuss how emerging proteomic technologies can become a useful tool to
      monitor the (de)differentiation status of ESCs and iPSCs.
FAU - Reiland, Sonja
AU  - Reiland S
AD  - European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany.
FAU - Salekdeh, Ghasem Hosseini
AU  - Salekdeh GH
FAU - Krijgsveld, Jeroen
AU  - Krijgsveld J
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Expert Rev Proteomics
JT  - Expert review of proteomics
JID - 101223548
RN  - 0 (Chromatin)
RN  - 0 (Histones)
RN  - 0 (Receptors, Cell Surface)
SB  - IM
MH  - Animals
MH  - Cell Differentiation/genetics
MH  - Chromatin/genetics
MH  - Chromatography, Liquid
MH  - Embryonic Stem Cells/*metabolism
MH  - Evaluation Studies as Topic
MH  - Histones/analysis
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*metabolism
MH  - Mass Spectrometry
MH  - Mice
MH  - Phosphorylation/genetics
MH  - Protein Processing, Post-Translational/genetics
MH  - Proteomics/*methods
MH  - Receptors, Cell Surface/analysis
MH  - Regenerative Medicine
EDAT- 2011/02/19 06:00
MHDA- 2011/05/26 06:00
CRDT- 2011/02/19 06:00
PHST- 2011/02/19 06:00 [entrez]
PHST- 2011/02/19 06:00 [pubmed]
PHST- 2011/05/26 06:00 [medline]
AID - 10.1586/epr.10.100 [doi]
PST - ppublish
SO  - Expert Rev Proteomics. 2011 Feb;8(1):29-42. doi: 10.1586/epr.10.100.


PMID- 21329102
OWN - NLM
STAT- MEDLINE
DCOM- 20110407
LR  - 20191112
IS  - 0093-0334 (Print)
IS  - 0093-0334 (Linking)
VI  - 41
IP  - 1
DP  - 2011 Jan-Feb
TI  - Values engineering: the ethics of design in community health centers.
PG  - 27-8
FAU - Boltin, Benjamin
AU  - Boltin B
AD  - The Hasting Center, USA.
FAU - Berlinger, Nancy
AU  - Berlinger N
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Hastings Cent Rep
JT  - The Hastings Center report
JID - 0410447
SB  - IM
MH  - American Recovery and Reinvestment Act/*economics
MH  - Architectural Accessibility/ethics/standards
MH  - Child
MH  - Child Health Services/economics
MH  - Community Health Centers/economics/ethics/*standards
MH  - Economic Recession
MH  - Engineering/standards
MH  - Environment Design/standards
MH  - Facility Design and Construction/economics/ethics/*standards
MH  - Humans
MH  - Medicaid/economics
MH  - Medically Uninsured
MH  - Mobile Health Units/ethics/standards
MH  - State Health Plans/economics
MH  - United States
EDAT- 2011/02/19 06:00
MHDA- 2011/04/08 06:00
CRDT- 2011/02/19 06:00
PHST- 2011/02/19 06:00 [entrez]
PHST- 2011/02/19 06:00 [pubmed]
PHST- 2011/04/08 06:00 [medline]
AID - 10.1002/j.1552-146x.2011.tb00096.x [doi]
PST - ppublish
SO  - Hastings Cent Rep. 2011 Jan-Feb;41(1):27-8. doi:
      10.1002/j.1552-146x.2011.tb00096.x.


PMID- 21328725
OWN - NLM
STAT- MEDLINE
DCOM- 20110720
LR  - 20211020
IS  - 1332-8166 (Electronic)
IS  - 0353-9504 (Linking)
VI  - 52
IP  - 1
DP  - 2011 Feb
TI  - The founding of the Centre for Palliative Medicine, Medical Ethics and
      Communication Skills: a new step toward the development of patient-oriented
      medicine in Croatia.
PG  - 87-8
FAU - Dordevic, Veljko
AU  - Dordevic V
FAU - Bras, Marijana
AU  - Bras M
FAU - Milunovic, Vibor
AU  - Milunovic V
FAU - Brajkovic, Lovorka
AU  - Brajkovic L
FAU - Stevanovic, Ranko
AU  - Stevanovic R
FAU - Polasek, Ozren
AU  - Polasek O
LA  - eng
PT  - News
PL  - Croatia
TA  - Croat Med J
JT  - Croatian medical journal
JID - 9424324
SB  - IM
MH  - *Academic Medical Centers
MH  - Croatia
MH  - Education
MH  - *Ethics, Medical
MH  - Humans
MH  - Interdisciplinary Communication
MH  - *Medical Informatics
MH  - Organizational Innovation
MH  - Organizations/*organization & administration
MH  - *Palliative Care
PMC - PMC3046497
EDAT- 2011/02/18 06:00
MHDA- 2011/07/21 06:00
CRDT- 2011/02/18 06:00
PHST- 2011/02/18 06:00 [entrez]
PHST- 2011/02/18 06:00 [pubmed]
PHST- 2011/07/21 06:00 [medline]
AID - 10.3325/cmj.2011.52.87 [doi]
PST - ppublish
SO  - Croat Med J. 2011 Feb;52(1):87-8. doi: 10.3325/cmj.2011.52.87.


PMID- 21328508
OWN - NLM
STAT- MEDLINE
DCOM- 20111013
LR  - 20110407
IS  - 1549-4918 (Electronic)
IS  - 1066-5099 (Linking)
VI  - 29
IP  - 4
DP  - 2011 Apr
TI  - Molecular and functional characterizations of gastrula organizer cells derived
      from human embryonic stem cells.
PG  - 600-8
LID - 10.1002/stem.621 [doi]
AB  - The Spemann-Mangold organizer is the structure that provides the signals, which
      initiate pattern formation in the developing vertebrate embryo, affecting the
      main body axes. Very little is known about axial induction in the gastrulating
      human embryo, as research is hindered by obvious ethical restrictions. Human
      embryonic stem cells (hESCs) are pluripotent cells derived from the pregastrula
      embryo that can differentiate in culture following a program similar to normal
      embryonic development but without pattern formation. Here, we show that in
      hESC-derived embryoid bodies, we can induce differentiation of cells that harbor 
      markers and characteristics of the gastrula-organizer. Moreover, genetic labeling
      of these cells enabled their purification, and the discovery of a comprehensive
      set of their secreted proteins, cell surface receptors, and nuclear factors
      characteristic of the organizer. Remarkably, transplantation of cell populations 
      enriched for the putative human organizer into frog embryos induced a secondary
      axis. Our research demonstrates that the human organizer can be induced in vitro 
      and paves the way for the study of pattern formation and the initial regulation
      of body axis establishment in humans.
CI  - Copyright (c) 2011 AlphaMed Press.
FAU - Sharon, Nadav
AU  - Sharon N
AD  - Stem Cell Unit, Department of Genetics, Silberman Institute of Life Sciences, The
      Hebrew University, Jerusalem, Israel.
FAU - Mor, Ishay
AU  - Mor I
FAU - Golan-lev, Tamar
AU  - Golan-lev T
FAU - Fainsod, Abraham
AU  - Fainsod A
FAU - Benvenisty, Nissim
AU  - Benvenisty N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Stem Cells
JT  - Stem cells (Dayton, Ohio)
JID - 9304532
RN  - 0 (Goosecoid Protein)
RN  - 0 (Transforming Growth Factor beta)
RN  - 0 (Wnt Proteins)
SB  - IM
MH  - Body Patterning
MH  - Cell Differentiation/physiology
MH  - Embryoid Bodies/metabolism
MH  - Embryonic Induction
MH  - Embryonic Stem Cells/*metabolism
MH  - *Gastrulation
MH  - Gene Expression Regulation, Developmental
MH  - Goosecoid Protein/biosynthesis
MH  - Humans
MH  - Organizers, Embryonic/*metabolism
MH  - Signal Transduction
MH  - Transforming Growth Factor beta/metabolism
MH  - Wnt Proteins/metabolism
EDAT- 2011/02/18 06:00
MHDA- 2011/10/14 06:00
CRDT- 2011/02/18 06:00
PHST- 2011/02/18 06:00 [entrez]
PHST- 2011/02/18 06:00 [pubmed]
PHST- 2011/10/14 06:00 [medline]
AID - 10.1002/stem.621 [doi]
PST - ppublish
SO  - Stem Cells. 2011 Apr;29(4):600-8. doi: 10.1002/stem.621.


PMID- 21328213
OWN - NLM
STAT- MEDLINE
DCOM- 20110511
LR  - 20110217
IS  - 0047-262X (Print)
VI  - 58
IP  - 1
DP  - 2011 Feb
TI  - [Unity of knowing and action- exploring moral courage in nursing practice].
PG  - 102-7
AB  - Ethics is a core value of nursing, and hospital nurses will try, as much as
      possible, to be "good" in terms of established nursing ethics and values. Nurses 
      learn the value of providing "patient centered care" in school and try to
      establish relationships of trust with their patients in clinical settings.
      However, the realities of working in the hospital teaches nurses that actual
      situations are complex to the point of inducing "ethical dilemmas" and "moral
      distress" because of the many factors that affect medical decisions regarding
      individual patients. If nurses could follow their conscience in managing
      difficult ethical situations with moral courage, they would promote the value of 
      "good nurse" which is innate in both nurses and society. This article defines the
      parameters of conscience and moral courage, the conditions such should exhibit,
      strategies nurses should consider, and appropriate nursing training methods. The 
      authors hope to help foster the development of moral courage and create positive 
      practice environments for nursing staff.
FAU - Ko, Hsun-Kuei
AU  - Ko HK
AD  - School of Nursing, Kaohsiung Medical University, ROC.
FAU - Wang, Ruey-Hsia
AU  - Wang RH
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China (Republic : 1949- )
TA  - Hu Li Za Zhi
JT  - Hu li za zhi The journal of nursing
JID - 0073267
SB  - IM
MH  - *Ethics, Nursing
MH  - Humans
MH  - *Morals
EDAT- 2011/02/18 06:00
MHDA- 2011/05/12 06:00
CRDT- 2011/02/18 06:00
PHST- 2011/02/18 06:00 [entrez]
PHST- 2011/02/18 06:00 [pubmed]
PHST- 2011/05/12 06:00 [medline]
PST - ppublish
SO  - Hu Li Za Zhi. 2011 Feb;58(1):102-7.


PMID- 21328113
OWN - NLM
STAT- MEDLINE
DCOM- 20110818
LR  - 20110414
IS  - 1465-3419 (Electronic)
IS  - 1355-7858 (Linking)
VI  - 16
IP  - 2
DP  - 2011 Apr
TI  - Muslim women's reflections on the acceptability of vaginal microbicidal products 
      to prevent HIV infection.
PG  - 89-106
LID - 10.1080/13557858.2010.539196 [doi]
AB  - This paper examines South African Muslim women's opinions of the acceptability of
      microbicidal products to prevent HIV infection if these were to become available 
      in the future. In the context of the HIV pandemic, prophylactic methods such as
      male circumcision, vaccines and microbicidal preparations are increasingly
      thought of as ways to reduce the incidence of infection. We examine the extent to
      which participants' religious beliefs and the implications of religious norms and
      ideals might influence decision-making concerning hypothetical acceptability to
      use a microbicide. We conducted qualitative interviews with 29 Muslim women
      residing in South Africa, a country with one of the highest HIV prevalence rates 
      in the world. Four themes emerged from the data, namely, (1) participants'
      questioning of the need for microbicides; (2) reasons they gave in favour of
      microbicide use; (3) the juxtaposition of microbicide use and religious ethics;
      and (4) the role of religious authorities in decision-making regarding
      microbicide use. The juxtaposition of microbicide use and religious ethics was
      further informed by three sub-themes, namely, the life-promoting nature of both
      Islam and microbicide use, the possibility that microbicide use could encourage
      sexual risk-taking among male partners, and that the use of these products
      contradicted womens' notions of ethical agency and ideals about marriage. These
      themes and sub-themes are analysed in the context of gender relations among South
      African Muslims. The study findings are significant in light of recent data
      showing the effectiveness of a microbicidal preparation in reducing the risk of
      HIV infection in South Africa. We also show that the acceptability of
      microbicidal products is to a certain extent linked to a variety of religious
      persuasions and ideals. When microbicides become available in the future,
      proponents of their use will need to consider religious reasoning of potential
      users, including that of Muslim women.
FAU - Hoel, Nina
AU  - Hoel N
AD  - Department of Religious Studies, University of Cape Town, Cape Town, South
      Africa.
FAU - Shaikh, Sadiyya
AU  - Shaikh S
FAU - Kagee, Ashraf
AU  - Kagee A
LA  - eng
PT  - Journal Article
PL  - England
TA  - Ethn Health
JT  - Ethnicity & health
JID - 9608374
RN  - 0 (Anti-Infective Agents, Local)
SB  - IM
MH  - Administration, Intravaginal
MH  - Adult
MH  - Aged
MH  - Anti-Infective Agents, Local/*administration & dosage
MH  - Female
MH  - HIV Infections/*prevention & control
MH  - Humans
MH  - Islam/*psychology
MH  - Male
MH  - Middle Aged
MH  - Patient Acceptance of Health Care/*psychology
MH  - *Religion and Sex
MH  - Sexually Transmitted Diseases/*prevention & control
MH  - South Africa/ethnology
MH  - Women's Health
MH  - Young Adult
EDAT- 2011/02/18 06:00
MHDA- 2011/08/19 06:00
CRDT- 2011/02/18 06:00
PHST- 2011/02/18 06:00 [entrez]
PHST- 2011/02/18 06:00 [pubmed]
PHST- 2011/08/19 06:00 [medline]
AID - 933520923 [pii]
AID - 10.1080/13557858.2010.539196 [doi]
PST - ppublish
SO  - Ethn Health. 2011 Apr;16(2):89-106. doi: 10.1080/13557858.2010.539196.


PMID- 21327773
OWN - NLM
STAT- MEDLINE
DCOM- 20110812
LR  - 20220310
IS  - 1863-2300 (Electronic)
IS  - 1863-2297 (Linking)
VI  - 33
IP  - 2
DP  - 2011 Mar
TI  - Clinical transplantation tolerance.
PG  - 91-104
LID - 10.1007/s00281-011-0255-y [doi]
AB  - Transplantation is the treatment of choice for many if not most causes of
      end-stage organ failure. Over 20,000 organ transplant procedures were performed
      in the USA in 2009 to treat patients with failed or failing kidneys, livers,
      hearts, lungs, and intestines, and there remain 85,000 individuals waiting on the
      transplant list. Currently, in the USA, there are over 170,000 individuals living
      with a transplanted organ. Virtually, all of these individuals receive
      maintenance immunosuppression in an attempt to maximize the function and survival
      of the transplanted organ. However, it is clear that the long-term use of
      immunosuppressive agents is associated with an extensive list of undesirable side
      effects that have the potential to limit the survival of the patient and
      transplanted organ as well as to compromise quality of life. Although the ability
      to induce reproducibly a state of robust, stable tolerance would address this
      problem, tolerance remains an infrequent event in clinical transplantation that
      is largely a consequence of chance. Factors limiting the broader investigation of
      clinical transplantation tolerance include the lack of therapeutic regimens known
      to favor tolerance in humans, the lack of validated assays or biomarkers
      predictive of tolerance, and concerns about the safety and ethics of complete
      withdrawal of immunosuppression given the very good results achievable with
      current immunosuppression. Despite these barriers, a number of investigators have
      continued to conduct well-designed and carefully supervised studies with the
      long-term goal of making clinical transplantation tolerance more feasible. The
      aim of this review is to summarize the status of these studies.
FAU - Newell, Kenneth A
AU  - Newell KA
AD  - Department of Surgery and the Emory Transplant Center, Emory University, Atlanta,
      GA 30322, USA. kanewel@emory.edu
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110214
PL  - Germany
TA  - Semin Immunopathol
JT  - Seminars in immunopathology
JID - 101308769
SB  - IM
MH  - Humans
MH  - Immune Tolerance/genetics/immunology
MH  - Immunosuppression Therapy
MH  - Kidney Transplantation/immunology
MH  - Liver Transplantation/immunology
MH  - Transplantation Tolerance/genetics/*immunology
EDAT- 2011/02/18 06:00
MHDA- 2011/08/13 06:00
CRDT- 2011/02/18 06:00
PHST- 2010/11/20 00:00 [received]
PHST- 2011/01/13 00:00 [accepted]
PHST- 2011/02/18 06:00 [entrez]
PHST- 2011/02/18 06:00 [pubmed]
PHST- 2011/08/13 06:00 [medline]
AID - 10.1007/s00281-011-0255-y [doi]
PST - ppublish
SO  - Semin Immunopathol. 2011 Mar;33(2):91-104. doi: 10.1007/s00281-011-0255-y. Epub
      2011 Feb 14.


PMID- 21327770
OWN - NLM
STAT- MEDLINE
DCOM- 20120315
LR  - 20211020
IS  - 1432-1920 (Electronic)
IS  - 0028-3940 (Linking)
VI  - 53
IP  - 7
DP  - 2011 Jul
TI  - When research is reconciled with care and ethics with science, reimbursement for 
      clinical procedures can be linked to trial participation.
PG  - 541-3
LID - 10.1007/s00234-011-0843-5 [doi]
FAU - Raymond, Jean
AU  - Raymond J
FAU - Darsaut, Tim E
AU  - Darsaut TE
LA  - eng
PT  - Letter
PT  - Comment
DEP - 20110216
PL  - Germany
TA  - Neuroradiology
JT  - Neuroradiology
JID - 1302751
SB  - IM
CON - Neuroradiology. 2010 Nov;52(11):1061-2. PMID: 20737141
MH  - *Government Regulation
MH  - Neuroradiography/*standards
MH  - Randomized Controlled Trials as Topic/*legislation & jurisprudence
MH  - Vascular Surgical Procedures/*standards
EDAT- 2011/02/18 06:00
MHDA- 2012/03/16 06:00
CRDT- 2011/02/18 06:00
PHST- 2011/01/10 00:00 [received]
PHST- 2011/01/28 00:00 [accepted]
PHST- 2011/02/18 06:00 [entrez]
PHST- 2011/02/18 06:00 [pubmed]
PHST- 2012/03/16 06:00 [medline]
AID - 10.1007/s00234-011-0843-5 [doi]
PST - ppublish
SO  - Neuroradiology. 2011 Jul;53(7):541-3. doi: 10.1007/s00234-011-0843-5. Epub 2011
      Feb 16.


PMID- 21327728
OWN - NLM
STAT- MEDLINE
DCOM- 20111214
LR  - 20220318
IS  - 1434-4726 (Electronic)
IS  - 0937-4477 (Linking)
VI  - 268
IP  - 9
DP  - 2011 Sep
TI  - Treatment of sudden sensorineural hearing loss with transtympanic injection of
      steroids as single therapy: a randomized clinical study.
PG  - 1273-8
LID - 10.1007/s00405-011-1523-0 [doi]
AB  - The aim of this study was to verify the efficacy and the safety of transtympanic 
      dexamethasone to treat sudden sensorineural hearing loss as first and single drug
      method. Considering ethical implication of performing a mininvasive procedure on 
      middle ear, we matched such proposed treatment with systemic prednisone
      administration that represents the widest adopted protocol. Randomized
      prospective study was conducted. The inclusion criterion was a sudden
      sensorineural hearing loss of at least 30 dB across three contiguous frequencies 
      over a period of 24 h. Group A received transtympanic steroid injections; Group B
      received oral administration of steroids. 25 patients were treated with
      transtympanic therapy whereas 21 underwent systemic treatment. The mean of
      initial PTA was 59 dB for the whole series: 65 dB for group A and 51 dB for group
      B. The recovery better than 10 dB was obtained in 80% of patients of group A and 
      in 17 81% of patients of group B, with a total of 80.5%. The mean relative gain
      in PTA was 41.16% in the group A and 44.7% in the group B. In the frequencies
      tested (0.5, 1, 2, and 4 kHz) PTA improvements after transtympanic treatment were
      higher than after systemic treatment, but these differences were not
      statistically significant (P = 0.61). Both transtympanic and systemic treatment
      had similar clinical recovery times. This prospective randomized clinical study
      showed good result in terms of hearing recovery, better than the expected results
      of the simple observation without treatment. We can consider transtympanic
      administration as a first line treatment, because of the statistical analysis
      confirmed similar results with systemic therapy, reducing possible side effects
      of systemic drug administration. The delay of treatment does not influence the
      outcome, allowing treating patients within 10 days of onset.
FAU - Dispenza, Francesco
AU  - Dispenza F
AD  - Dipartimento Discipline Chirurgiche e Oncologiche-U.O. Otorinolaringoiatria,
      Universita degli Studi di Palermo, Palermo, Italy. francesco.dispenza@gmail.com
FAU - Amodio, Emanuele
AU  - Amodio E
FAU - De Stefano, Alessandro
AU  - De Stefano A
FAU - Gallina, Salvatore
AU  - Gallina S
FAU - Marchese, Donatella
AU  - Marchese D
FAU - Mathur, Navneet
AU  - Mathur N
FAU - Riggio, Francesco
AU  - Riggio F
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20110216
PL  - Germany
TA  - Eur Arch Otorhinolaryngol
JT  - European archives of oto-rhino-laryngology : official journal of the European
      Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the
      German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JID - 9002937
RN  - 7S5I7G3JQL (Dexamethasone)
SB  - IM
MH  - Administration, Oral
MH  - Adult
MH  - Aged
MH  - Analysis of Variance
MH  - Audiometry/methods
MH  - Dexamethasone/*administration & dosage
MH  - Dose-Response Relationship, Drug
MH  - Drug Administration Schedule
MH  - Female
MH  - Follow-Up Studies
MH  - Hearing Loss, Sensorineural/diagnosis/*drug therapy
MH  - Hearing Loss, Sudden/diagnosis/*drug therapy
MH  - Humans
MH  - Injections, Intralesional
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Risk Assessment
MH  - Severity of Illness Index
MH  - Treatment Outcome
MH  - Tympanic Membrane/*drug effects
EDAT- 2011/02/18 06:00
MHDA- 2011/12/15 06:00
CRDT- 2011/02/18 06:00
PHST- 2010/10/27 00:00 [received]
PHST- 2011/02/01 00:00 [accepted]
PHST- 2011/02/18 06:00 [entrez]
PHST- 2011/02/18 06:00 [pubmed]
PHST- 2011/12/15 06:00 [medline]
AID - 10.1007/s00405-011-1523-0 [doi]
PST - ppublish
SO  - Eur Arch Otorhinolaryngol. 2011 Sep;268(9):1273-8. doi:
      10.1007/s00405-011-1523-0. Epub 2011 Feb 16.


PMID- 21326261
OWN - NLM
STAT- MEDLINE
DCOM- 20110404
LR  - 20211020
IS  - 1532-6535 (Electronic)
IS  - 0009-9236 (Linking)
VI  - 89
IP  - 3
DP  - 2011 Mar
TI  - Ethical issues in developing pharmacogenetic research partnerships with American 
      Indigenous communities.
PG  - 343-5
LID - 10.1038/clpt.2010.303 [doi]
AB  - Pharmacogenetic research offers the potential to improve the safety and efficacy 
      of drug prescribing. Assuring that the benefits of this research reach indigenous
      and other medically underserved people is an important justice concern. First,
      however, a legacy of mistrust, derived from traditional research practices that
      disempower communities, must be overcome. Linking pharmacogenetic research to
      collaborative, power-sharing research partnerships provides a valuable
      opportunity to develop new and positive precedents for genetic research in
      indigenous communities.
FAU - Boyer, B B
AU  - Boyer BB
AD  - Center for Alaska Native Health Research, University of Alaska Fairbanks,
      Fairbanks, Alaska, USA.
FAU - Dillard, D
AU  - Dillard D
FAU - Woodahl, E L
AU  - Woodahl EL
FAU - Whitener, R
AU  - Whitener R
FAU - Thummel, K E
AU  - Thummel KE
FAU - Burke, W
AU  - Burke W
LA  - eng
GR  - U01 GM092676-01/GM/NIGMS NIH HHS/United States
GR  - P20 RR016430/RR/NCRR NIH HHS/United States
GR  - 1U01GM092676-01/GM/NIGMS NIH HHS/United States
GR  - P20 RR016430-09/RR/NCRR NIH HHS/United States
GR  - U01 GM092676/GM/NIGMS NIH HHS/United States
GR  - 5P20RR016430-09/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Clin Pharmacol Ther
JT  - Clinical pharmacology and therapeutics
JID - 0372741
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Community-Based Participatory Research/organization & administration
MH  - Cooperative Behavior
MH  - Drug-Related Side Effects and Adverse Reactions
MH  - Genetic Research/*ethics
MH  - Health Services Accessibility
MH  - Humans
MH  - *Indians, North American
MH  - Medically Underserved Area
MH  - Pharmaceutical Preparations/*administration & dosage
MH  - Pharmacogenetics/*ethics/organization & administration
MH  - Practice Patterns, Physicians'
MH  - Trust
MH  - United States
PMC - PMC3090734
MID - NIHMS287602
EDAT- 2011/02/18 06:00
MHDA- 2011/04/05 06:00
CRDT- 2011/02/18 06:00
PHST- 2011/02/18 06:00 [entrez]
PHST- 2011/02/18 06:00 [pubmed]
PHST- 2011/04/05 06:00 [medline]
AID - clpt2010303 [pii]
AID - 10.1038/clpt.2010.303 [doi]
PST - ppublish
SO  - Clin Pharmacol Ther. 2011 Mar;89(3):343-5. doi: 10.1038/clpt.2010.303.


PMID- 21326034
OWN - NLM
STAT- MEDLINE
DCOM- 20110504
LR  - 20191210
IS  - 1533-4066 (Electronic)
IS  - 1052-9551 (Linking)
VI  - 20
IP  - 1
DP  - 2011 Mar
TI  - Validation of the multiplex ligation-dependent probe amplification (MLPA)
      technique for the determination of HER2 gene amplification in breast cancer.
PG  - 11-7
LID - 10.1097/PDM.0b013e3181ed7832 [doi]
AB  - BACKGROUND: Multiplex ligation-dependent probe amplification (MLPA) is a
      polymerase chain reaction-based assay that can assess HER2 gene copy number
      relative to control genes. DESIGN: Institutional ethics board approval was
      obtained. Using commercially available kits, 208 consecutive invasive breast
      cancers undergoing routine in situ hybridization testing (chromogenic in situ
      hybridization and fluorescence in situ hybridization) were also tested
      independently by MLPA. The American Society of Clinical Oncology/College of
      American Pathologists guidelines were applied for the reporting of ISH results.
      In accordance with earlier studies, MLPA results were reported as amplified when 
      the HER2 gene copy number per cell was >/= 4.0. RESULTS: At the conclusion of all
      ISH testing 25 of 208 cases (12.0%) were regarded as amplified, 182 (87.5%) as
      nonamplified, and 1 case (0.5%) as undetermined owing to insufficient tissue.
      This case is excluded from further analysis. Of the 182 cases categorized as not 
      amplified by ISH, all were also negative by MLPA. Of the 25 cases amplified by
      ISH, 23 (92.0%) were amplified by MLPA, but the 2 remaining ISH-amplified cases
      were negative by MLPA. Using ISH as the reference test, MLPA has the following
      diagnostic indices: sensitivity 92.0%, specificity 100%, positive predictive
      value 100%, negative predictive value 98.9%, and overall accuracy 99.0%.
      CONCLUSIONS: The high level of concordance between MLPA and ISH results,
      exceeding the American Society of Clinical Oncology requirements for validation
      of a new test, supports the use of MLPA for assessment of HER2-amplification.
      These results merit further consideration of MLPA as a possible alternative or
      additional platform for HER2 testing.
FAU - Farshid, Gelareh
AU  - Farshid G
AD  - Royal Adelaide Hospital campus, SA Pathology, BreastScreen, SA.
      gelareh.farshid@health.sa.gov.au
FAU - Cheetham, Glenice
AU  - Cheetham G
FAU - Davies, Ruth
AU  - Davies R
FAU - Moore, Sarah
AU  - Moore S
FAU - Rudzki, Zbigniew
AU  - Rudzki Z
LA  - eng
PT  - Journal Article
PT  - Validation Study
PL  - United States
TA  - Diagn Mol Pathol
JT  - Diagnostic molecular pathology : the American journal of surgical pathology, part
      B
JID - 9204924
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Biomarkers, Tumor/*genetics/metabolism
MH  - Breast Neoplasms/diagnosis/*genetics/metabolism
MH  - Female
MH  - *Gene Amplification
MH  - Gene Dosage
MH  - Genes, erbB-2/*genetics
MH  - Humans
MH  - In Situ Hybridization
MH  - Polymerase Chain Reaction/*methods
EDAT- 2011/02/18 06:00
MHDA- 2011/05/05 06:00
CRDT- 2011/02/18 06:00
PHST- 2011/02/18 06:00 [entrez]
PHST- 2011/02/18 06:00 [pubmed]
PHST- 2011/05/05 06:00 [medline]
AID - 10.1097/PDM.0b013e3181ed7832 [doi]
AID - 00019606-201103000-00002 [pii]
PST - ppublish
SO  - Diagn Mol Pathol. 2011 Mar;20(1):11-7. doi: 10.1097/PDM.0b013e3181ed7832.


PMID- 21325099
OWN - NLM
STAT- MEDLINE
DCOM- 20110928
LR  - 20220409
IS  - 1542-6270 (Electronic)
IS  - 1060-0280 (Linking)
VI  - 45
IP  - 3
DP  - 2011 Mar
TI  - Provision of primary care to patients with chronic cough in the community
      pharmacy setting.
PG  - 402-8
LID - 10.1345/aph.1P514 [doi]
AB  - BACKGROUND: Community pharmacies are at the forefront of primary care providers
      and have an important role in the referral of patients to a medical practitioner 
      for review when necessary. Chronic cough is a common disorder in the community
      and requires medical assessment. The proficiency of community pharmacy staff to
      refer patients with chronic cough is currently unknown. OBJECTIVE: To assess the 
      ability of community pharmacy staff to recognize and medically refer patients
      with a chronic nonproductive cough. METHODS: Following ethics approval, a
      simulated patient study of 156 community pharmacies in Perth, Western Australia, 
      was conducted over a 3-month period. Simulated patients presented to the pharmacy
      requesting treatment for a cough. The simulated patient required a referral based
      on a designated scenario. Demographic details, assessment questions, and advice
      provided were recorded by the simulated patient immediately postvisit. A logistic
      regression analysis was performed, with referral for medical assessment as the
      dependent variable. RESULTS: Of the 155 community pharmacies included in the
      analysis, 38% provided appropriate medical referral. Cough suppressants were
      provided as therapy in 72% of all visits. Predictors of medical referral were
      assessment of symptom duration, medical history, current medications being taken,
      frequency of reliever use, and the position of the pharmacy staff member
      conducting the consultation. A third of community pharmacies provided appropriate
      primary care by recommending medical referral advice to patients with chronic
      cough. The majority of pharmacy staff members acquired information from the
      patient that suggested a need for medical referral, yet did not provide referral 
      advice. CONCLUSIONS: Appropriate medical referral is more likely when adequate
      assessment is undertaken and when a pharmacist is directly involved in the
      consultation. This highlights the need for pharmacies to ensure that processes
      are in place for patients to access the pharmacist.
FAU - Schneider, Carl R
AU  - Schneider CR
AD  - School of Biomedical, Biomolecular and Chemical Sciences, The University of
      Western Australia, Crawley, Australia. c.r.schneider@aston.ac.uk
FAU - Everett, Alan W
AU  - Everett AW
FAU - Geelhoed, Elizabeth
AU  - Geelhoed E
FAU - Kendall, Peter A
AU  - Kendall PA
FAU - Murray, Kevin
AU  - Murray K
FAU - Garnett, Peter
AU  - Garnett P
FAU - Salama, Mariam
AU  - Salama M
FAU - Clifford, Rhonda M
AU  - Clifford RM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110215
PL  - United States
TA  - Ann Pharmacother
JT  - The Annals of pharmacotherapy
JID - 9203131
SB  - IM
MH  - Chronic Disease
MH  - Community Pharmacy Services
MH  - Cough/*drug therapy
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Male
MH  - Patient Simulation
MH  - Pharmacies
MH  - *Pharmacists
MH  - *Primary Health Care
MH  - Referral and Consultation
MH  - Western Australia
EDAT- 2011/02/18 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/02/18 06:00
PHST- 2011/02/18 06:00 [entrez]
PHST- 2011/02/18 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - aph.1P514 [pii]
AID - 10.1345/aph.1P514 [doi]
PST - ppublish
SO  - Ann Pharmacother. 2011 Mar;45(3):402-8. doi: 10.1345/aph.1P514. Epub 2011 Feb 15.


PMID- 21324840
OWN - NLM
STAT- MEDLINE
DCOM- 20110527
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 259
IP  - 1
DP  - 2011 Apr
TI  - Early measurement of pulsatility and resistive indexes: correlation with
      long-term renal transplant function.
PG  - 278-85
LID - 10.1148/radiol.10101329 [doi]
AB  - PURPOSE: To correlate pulsatility index (PI) and resistive index (RI) measured at
      early specific intervals after transplantation with 1-year estimated glomerular
      filtration rate (eGFR) and death-censored transplant survival to assess the
      long-term prognostic value of these Doppler indexes. MATERIALS AND METHODS: The
      local ethics committee was consulted, and no formal approval was required. This
      retrospective review included 178 consecutive patients (111 male, 67 female; mean
      age, 43.9 years +/- 13.4 [standard deviation]; age range, 16-72 years) undergoing
      first deceased-donor renal transplantation between 1997 and 2000. All patients
      were identified from a prospectively maintained database. Spectral Doppler
      analysis was performed within 1 week after transplantation in all patients and
      between 1 week and 3 months after transplantation in 124 patients. Average PI and
      RI were determined from measurements obtained in the upper, lower, and interpolar
      regions. For statistical analysis, the chi(2) test, analysis of variance, the
      Student t test, Kaplan-Meier survival plots, and Cox proportional hazards models 
      were used. RESULTS: Within 1 week after transplantation, there was a significant 
      association between PI and 1-year eGFR when analyzed as tertiles (P = .02).
      Between 1 week and 3 months after transplantation, there was a significant
      relationship between 1-year eGFR and both PI and RI when comparing the lowest and
      highest tertiles (47.5 mL/min/1.73 m(2) for PI <1.26 vs 32.7 mL/min/1.73 m(2) for
      PI >1.49 [P = .01], 42.8 mL/min/1.73 m(2) for RI <0.69 vs 32.3 mL/min/1.73 m(2)
      for RI >0.74 [P = .03]). Both PI and RI were independent predictors of
      death-censored transplant survival (hazard ratio, 1.68 per unit [P < .001] and
      260.4 per unit, respectively [P = .02]). CONCLUSION: PI and RI in the early
      posttransplantation period correlate with long-term transplant function and can
      potentially be used as prognostic markers to aid risk stratification for future
      transplant dysfunction.
CI  - (c) RSNA, 2011.
FAU - McArthur, Claire
AU  - McArthur C
AD  - Department of Radiology and Renal Medicine, Western Infirmary, Dumbarton Rd,
      Glasgow G11 6NT, Scotland. claire.mcarthur@nhs.net
FAU - Geddes, Colin C
AU  - Geddes CC
FAU - Baxter, Grant M
AU  - Baxter GM
LA  - eng
PT  - Journal Article
DEP - 20110128
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Female
MH  - *Health Status Indicators
MH  - Humans
MH  - Kidney Function Tests/*methods/*statistics & numerical data
MH  - Kidney Transplantation/*diagnostic imaging/*mortality
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Prognosis
MH  - Pulsatile Flow
MH  - Reproducibility of Results
MH  - Risk Assessment/methods
MH  - Risk Factors
MH  - Scotland/epidemiology
MH  - Sensitivity and Specificity
MH  - Statistics as Topic
MH  - Survival Analysis
MH  - Survival Rate
MH  - Treatment Outcome
MH  - Ultrasonography, Doppler/*methods/*statistics & numerical data
MH  - Vascular Resistance
MH  - Young Adult
EDAT- 2011/02/18 06:00
MHDA- 2011/05/28 06:00
CRDT- 2011/02/18 06:00
PHST- 2011/02/18 06:00 [entrez]
PHST- 2011/02/18 06:00 [pubmed]
PHST- 2011/05/28 06:00 [medline]
AID - radiol.10101329 [pii]
AID - 10.1148/radiol.10101329 [doi]
PST - ppublish
SO  - Radiology. 2011 Apr;259(1):278-85. doi: 10.1148/radiol.10101329. Epub 2011 Jan
      28.


PMID- 21324839
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20220409
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 259
IP  - 2
DP  - 2011 May
TI  - Muscle fat fraction in neuromuscular disorders: dual-echo dual-flip-angle spoiled
      gradient-recalled MR imaging technique for quantification--a feasibility study.
PG  - 487-94
LID - 10.1148/radiol.10101108 [doi]
AB  - PURPOSE: To prospectively evaluate the muscle fat fraction (MFF) measured with
      dual-echo dual-flip-angle spoiled gradient-recalled acquisition in the steady
      state (SPGR) magnetic resonance (MR) imaging technique by using muscle biopsy as 
      the reference standard. MATERIALS AND METHODS: After ethics approval, written
      informed consent from all patients was obtained. Twenty-seven consecutive
      patients, evaluated at the Neuromuscular Disorders Center with a possible
      diagnosis of neuromuscular disorder, were prospectively studied with MR imaging
      of the lower extremities to quantify muscle fatty infiltration by means of MFF
      calculation. Spin-density- and T1-weighted fast SPGR in-phase and opposed-phase
      dual-echo sequences were performed, respectively, with 20 degrees and 80 degrees 
      flip angles. Round regions of interest were drawn by consensus on selected MR
      sections corresponding to anticipated biopsy sites. These were marked on the
      patient's skin with a pen by using the infrared spider light of the system, and
      subsequent muscle biopsy was performed. MR images with regions of interest were
      stored on a secondary console where the MFF calculation was performed by another 
      radiologist blinded to the biopsy results. MFFs calculated with dual-echo
      dual-flip-angle SPGR MR imaging and biopsy were compared by using a paired t
      test, Pearson correlation coefficient, and Bland-Altman plots. P value of < .05
      was considered to indicate a statistically significant difference. RESULTS: The
      mean MFFs obtained with dual-echo dual-flip-angle SPGR MR imaging and biopsy were
      20.3% (range, 1.7%-45.1%) and 20.6% (range, 3%-46.1%), respectively. The mean
      difference, standard deviation of the difference, and t value were -0.3, 1.3, and
      -1.3 (P > .2), respectively. The Pearson correlation coefficient was 0.995; with 
      the Bland-Altman method, all data points were within the +/- 2 SDs limits of
      agreement. CONCLUSION: The results show that dual-echo dual-flip-angle SPGR MR
      imaging technique provides reliable calculation of MFF, consistent with biopsy
      measurements.
CI  - RSNA, 2011
FAU - Gaeta, Michele
AU  - Gaeta M
AD  - Department of Radiological Sciences, Policlinico G. Martino, Via Consolare
      Valeria 1, 98125 Messina, Italy.
FAU - Scribano, Emanuele
AU  - Scribano E
FAU - Mileto, Achille
AU  - Mileto A
FAU - Mazziotti, Silvio
AU  - Mazziotti S
FAU - Rodolico, Carmelo
AU  - Rodolico C
FAU - Toscano, Antonio
AU  - Toscano A
FAU - Settineri, Nicola
AU  - Settineri N
FAU - Ascenti, Giorgio
AU  - Ascenti G
FAU - Blandino, Alfredo
AU  - Blandino A
LA  - eng
PT  - Journal Article
DEP - 20110128
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adipose Tissue/*pathology
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Biopsy
MH  - Child
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Linear Models
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Muscle, Skeletal/*pathology
MH  - Muscular Atrophy/pathology
MH  - Neuromuscular Diseases/*diagnosis
MH  - Prospective Studies
EDAT- 2011/02/18 06:00
MHDA- 2011/07/27 06:00
CRDT- 2011/02/18 06:00
PHST- 2011/02/18 06:00 [entrez]
PHST- 2011/02/18 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
AID - radiol.10101108 [pii]
AID - 10.1148/radiol.10101108 [doi]
PST - ppublish
SO  - Radiology. 2011 May;259(2):487-94. doi: 10.1148/radiol.10101108. Epub 2011 Jan
      28.


PMID- 21324120
OWN - NLM
STAT- MEDLINE
DCOM- 20110516
LR  - 20220331
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 12
DP  - 2011 Feb 15
TI  - How participatory is parental consent in low literacy rural settings in low
      income countries? Lessons learned from a community based study of infants in
      South India.
PG  - 3
LID - 10.1186/1472-6939-12-3 [doi]
AB  - BACKGROUND: A requisite for ethical human subjects research is that participation
      should be informed and voluntary. Participation during the informed consent
      process by way of asking questions is an indicator of the extent to which consent
      is informed. AIMS: The aims of this study were to assess the extent to which
      parents providing consent for children's participation in an observational
      tuberculosis (TB) research study in India actively participated during the
      informed consent discussion, and to identify correlates of that participation.
      METHODS: In an observational cohort study of tuberculosis in infants in South
      India, field supervisors who were responsible for obtaining informed consent
      noted down questions asked during the informed consent discussions for 4,382
      infants who were enrolled in the study. These questions were post-coded by topic.
      Bivariate and multivariate analysis was conducted to examine factors associated
      with asking at least one question during the informed consent process. RESULTS:
      In total, 590 out of 4,382 (13.4%) parents/guardians asked any question during
      the informed consent process. We found that the likelihood of parents asking
      questions during the informed consent process was significantly associated with
      education level of either parent both parents being present, and location.
      CONCLUSIONS: The findings have implications for planning the informed consent
      process in a largely rural setting with low levels of literacy. Greater effort
      needs to be directed towards developing simple participatory communication
      materials for the informed consent process. Furthermore, including both parents
      in a discussion about a child's participation in a research study may increase
      the extent to which consent is truly informed. Finally, continuing efforts need
      to be made to improve the communication skills of research workers with regard to
      explaining research processes and putting potential research participants at
      ease.
FAU - Rajaraman, Divya
AU  - Rajaraman D
AD  - Division of Epidemiology, St John's Research Institute, Bangalore, India.
      divya.rajaraman@sjri.res.in
FAU - Jesuraj, Nelson
AU  - Jesuraj N
FAU - Geiter, Lawrence
AU  - Geiter L
FAU - Bennett, Sean
AU  - Bennett S
FAU - Grewal, Harleen Ms
AU  - Grewal HM
FAU - Vaz, Mario
AU  - Vaz M
CN  - TB Trials Study Group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110215
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - *Developing Countries
MH  - Educational Status
MH  - Female
MH  - Humans
MH  - *Income
MH  - India
MH  - Infant
MH  - Male
MH  - Multivariate Analysis
MH  - Parental Consent/*ethics
MH  - *Parents
MH  - Research Personnel/education
MH  - Residence Characteristics
MH  - *Rural Population/statistics & numerical data
MH  - Socioeconomic Factors
MH  - Surveys and Questionnaires
MH  - Tuberculosis
PMC - PMC3050861
IR  - Vaz M
FIR - Vaz, Mario
IR  - Kurpad AV
FIR - Kurpad, Anura V
IR  - Kenneth J
FIR - Kenneth, John
IR  - Macaden R
FIR - Macaden, Rajini
IR  - Jacob A
FIR - Jacob, Auburn
IR  - Grewal H
FIR - Grewal, Harleen
IR  - Lindtjorn B
FIR - Lindtjorn, Bernt
IR  - Jahnsen F
FIR - Jahnsen, Frode
IR  - Bennett S
FIR - Bennett, Sean
IR  - Geiter L
FIR - Geiter, Lawrence
IR  - Doherty M
FIR - Doherty, Mark
IR  - Hesseling AC
FIR - Hesseling, Anneke C
EDAT- 2011/02/18 06:00
MHDA- 2011/05/17 06:00
CRDT- 2011/02/18 06:00
PHST- 2010/07/09 00:00 [received]
PHST- 2011/02/15 00:00 [accepted]
PHST- 2011/02/18 06:00 [entrez]
PHST- 2011/02/18 06:00 [pubmed]
PHST- 2011/05/17 06:00 [medline]
AID - 1472-6939-12-3 [pii]
AID - 10.1186/1472-6939-12-3 [doi]
PST - epublish
SO  - BMC Med Ethics. 2011 Feb 15;12:3. doi: 10.1186/1472-6939-12-3.


PMID- 21324070
OWN - NLM
STAT- MEDLINE
DCOM- 20110617
LR  - 20220409
IS  - 1743-498X (Electronic)
IS  - 1743-4971 (Linking)
VI  - 8
IP  - 1
DP  - 2011 Mar
TI  - Online role-playing for faculty development.
PG  - 31-6
LID - 10.1111/j.1743-498X.2010.00401.x [doi]
AB  - BACKGROUND: There has been a rapid growth of online teaching in the past few
      years, yet the implementation of role-play for formal educational activities in
      an online setting is growing more slowly. The use of online role-playing for the 
      development of health professions educators is virtually un-documented in the
      literature. INNOVATION: In the project reported here we use role-playing as a
      method to motivate and increase active participation in an online web-based
      discussion on community-based medical education (CBME). The Foundation for
      Advancement of International Medical Education & Research (FAIMER((R)) )
      Institute hosts virtual group discussions for fellows as part of its fellowship
      programmes, in order to deepen their knowledge base in health professions
      education and research. In June 2008, a group of seven FAIMER((R)) fellows and
      faculty members moderated an online discussion on CBME using an online role-play 
      exercise with other fellows and faculty members. RESULTS: Out of a total of 102
      fellows, 36 (35.3%) participated actively, which exceeded the typical percentage 
      of list server participation. In addition, a rich discussion resulted in a
      comprehensive report on the goals, challenges, logistical components, role of
      Health Ministry policy and the possible ethical mandate of CBME in developing
      countries. CONCLUSION: Online role-play encouraged distributed participation
      among a highly diverse international group of participants, supporting the
      conclusion that role-playing can be used effectively with mid-career health
      professional faculty members in the online environment.
CI  - (c) Blackwell Publishing Ltd 2011.
FAU - Ladhani, Zahra
AU  - Ladhani Z
AD  - Department of Community Health, Shifa College of Nursing, Islamabad, Pakistan.
      zladhani@yahoo.com
FAU - Chhatwal, Jugesh
AU  - Chhatwal J
FAU - Vyas, Rashmi
AU  - Vyas R
FAU - Iqbal, Mobeen
AU  - Iqbal M
FAU - Tan, Christina
AU  - Tan C
FAU - Diserens, Deborah
AU  - Diserens D
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Teach
JT  - The clinical teacher
JID - 101227511
SB  - IM
MH  - Community Participation/methods
MH  - Curriculum
MH  - Education, Medical, Continuing/*methods
MH  - *Faculty, Medical
MH  - Health Knowledge, Attitudes, Practice
MH  - Health Policy
MH  - Humans
MH  - *Internet
MH  - Motivation
MH  - Philadelphia
MH  - Problem-Based Learning/methods
MH  - Program Development
MH  - Program Evaluation
MH  - *Role Playing
MH  - Staff Development/*methods
MH  - Teaching/*methods
EDAT- 2011/02/18 06:00
MHDA- 2011/06/18 06:00
CRDT- 2011/02/18 06:00
PHST- 2011/02/18 06:00 [entrez]
PHST- 2011/02/18 06:00 [pubmed]
PHST- 2011/06/18 06:00 [medline]
AID - 10.1111/j.1743-498X.2010.00401.x [doi]
PST - ppublish
SO  - Clin Teach. 2011 Mar;8(1):31-6. doi: 10.1111/j.1743-498X.2010.00401.x.


PMID- 21323998
OWN - NLM
STAT- MEDLINE
DCOM- 20110712
LR  - 20220321
IS  - 1525-139X (Electronic)
IS  - 0894-0959 (Linking)
VI  - 24
IP  - 1
DP  - 2011 Jan-Feb
TI  - Cherry picking in ESRD: an ethical challenge in the era of pay for performance.
PG  - 5-8
LID - 10.1111/j.1525-139X.2010.00806.x [doi]
AB  - In poorly designed pay-for-performance schemes in which case mix adjustments are 
      not adequate, self-interest could lead nephrologists toward cherry picking
      dialysis patients. Cherry picking, however, is morally problematic. First, it may
      manifest itself as a subtle form of covert rationing which threatens to undermine
      patient trust. Second, it involves shifting the burden of caring for sicker (and 
      less financially attractive) patients to other nephrologists and dialysis units
      that do not practice cherry picking, creating injustices in the health care
      system. Finally, it treats patients as mere means through which nephrologists
      achieve reimbursement instead of as persons possessing dignity and deserving of
      respect.
CI  - (c) 2011 Wiley Periodicals, Inc.
FAU - Parker, J Clint
AU  - Parker JC
LA  - eng
PT  - Editorial
DEP - 20110217
PL  - United States
TA  - Semin Dial
JT  - Seminars in dialysis
JID - 8911629
SB  - IM
MH  - Humans
MH  - Kidney Failure, Chronic/economics/*therapy
MH  - Nephrology/economics/*ethics
MH  - Physicians/*economics
MH  - Reimbursement, Incentive/*economics
MH  - Renal Dialysis/economics/*ethics
EDAT- 2011/02/18 06:00
MHDA- 2011/07/13 06:00
CRDT- 2011/02/18 06:00
PHST- 2011/02/18 06:00 [entrez]
PHST- 2011/02/18 06:00 [pubmed]
PHST- 2011/07/13 06:00 [medline]
AID - 10.1111/j.1525-139X.2010.00806.x [doi]
PST - ppublish
SO  - Semin Dial. 2011 Jan-Feb;24(1):5-8. doi: 10.1111/j.1525-139X.2010.00806.x. Epub
      2011 Feb 17.


PMID- 21323878
OWN - NLM
STAT- MEDLINE
DCOM- 20110704
LR  - 20191210
IS  - 1745-8315 (Electronic)
IS  - 0020-7578 (Linking)
VI  - 92
IP  - 1
DP  - 2011 Feb
TI  - Termination: the hidden face of analysis.
PG  - 57-73
LID - 10.1111/j.1745-8315.2010.00358.x [doi]
AB  - Although the question of analytic endings has been the subject of many
      contributions and round tables, it always presents a theoretical and clinical
      dilemma that remains unresolved by the search for more explicit criteria. The
      problem of the final phase is a post-Freudian development which coincides
      historically with the emergence of studies on the countertransference, and it
      presupposes prior questions concerning the goals and results of analytic
      treatment. The following question is posed: what is the specific psychoanalytic
      event of the final phase? The author begins by examining the theoretical issues
      linked to temporality and separation, clarifying certain clinical aspects linked 
      to the precession of the countertransference in determining the ending, before
      going on to illustrate a number of indicators with a clinical vignette. He
      proposes that the movement which develops in analysis from the transitional
      relationship towards the patient's capacity to 'stand on his own two feet' in the
      clinical setting constitutes a crucial factor in the decision to embark on the
      process of termination. The conclusion opens out onto ethical issues, in view of 
      the prior necessity for a movement to occur in the countertransference.
CI  - Copyright (c) 2011 Institute of Psychoanalysis.
FAU - Sirois, Francois
AU  - Sirois F
AD  - sirois.rondeau@sympatico.ca
LA  - eng
PT  - Journal Article
DEP - 20110111
PL  - England
TA  - Int J Psychoanal
JT  - The International journal of psycho-analysis
JID - 2985179R
SB  - IM
MH  - *Countertransference
MH  - Goals
MH  - Humans
MH  - *Professional-Patient Relations
MH  - Psychoanalytic Therapy/*methods
EDAT- 2011/02/18 06:00
MHDA- 2011/07/05 06:00
CRDT- 2011/02/18 06:00
PHST- 2011/02/18 06:00 [entrez]
PHST- 2011/02/18 06:00 [pubmed]
PHST- 2011/07/05 06:00 [medline]
AID - 10.1111/j.1745-8315.2010.00358.x [doi]
PST - ppublish
SO  - Int J Psychoanal. 2011 Feb;92(1):57-73. doi: 10.1111/j.1745-8315.2010.00358.x.
      Epub 2011 Jan 11.


PMID- 21322180
OWN - NLM
STAT- MEDLINE
DCOM- 20110512
LR  - 20191027
IS  - 1942-7611 (Electronic)
IS  - 1942-7603 (Linking)
VI  - 3
IP  - 1
DP  - 2011 Jan
TI  - The use of in vitro technologies and high-resolution/accurate-mass LC-MS to
      screen for metabolites of 'designer' steroids in the equine.
PG  - 74-87
AB  - Detection of androgenic-anabolic steroid abuse in equine sports requires
      knowledge of the drug's metabolism in order to target appropriate metabolites,
      especially where urine is the matrix of choice. Studying 'designer' steroid
      metabolism is problematic since it is difficult to obtain ethical approval for in
      vivo metabolism studies due to a lack of toxicological data. In this study, the
      equine in vitro metabolism of eight steroids available for purchase on the
      Internet is reported; including androsta-1,4,6-triene-3,17-dione,
      4-chloro,17alpha-methyl-androsta-1,4-diene-3,17beta-diol,
      estra-4,9-diene-3,17-dione, 4-hydroxyandrostenedione, 20-hydroxyecdysone,
      11-keto-androstenedione, 17alpha-methyldrostanolone, and tetrahydrogestrinone. In
      order to allow for retrospective analysis of sample testing data, the use of a
      high-resolution (HR) accurate-mass Thermo LTQ-Orbitrap liquid chromatography-mass
      spectrometry (LC-MS) instrument was employed for metabolite identification of
      underivatized sample extracts. The full scan LC-HRMS Orbitrap data were
      complimented by LC-HRMS/MS and gas-chromatography-mass spectrometry (GC-MS)
      experiments in order to provide fragmentation information and to ascertain
      whether GC-MS was capable of detecting any metabolite not detected by LC-HRMS.
      With the exception of 20-hydroxyecdysone, all compounds were found to be
      metabolized by equine liver S9 and/or microsomes. With the exception of
      17alpha-methyldrostanolone, which produced metabolites that could only be
      detected by GC-MS, the metabolites of all other compounds could be identified
      using LC-HRMS, thus allowing retrospective analysis of previously acquired
      full-scan data resulting from routine equine drug testing screens. In summary,
      while in vitro techniques do not serve as a replacement for more definitive in
      vivo studies in all situations, their use does offer an alternative in situations
      where it would not be ethical to administer untested drugs to animals.
FAU - Clarke, Adam
AU  - Clarke A
AD  - aclarke@hfl.co.uk
FAU - Scarth, James
AU  - Scarth J
FAU - Teale, Phil
AU  - Teale P
FAU - Pearce, Clive
AU  - Pearce C
FAU - Hillyer, Lynn
AU  - Hillyer L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Drug Test Anal
JT  - Drug testing and analysis
JID - 101483449
RN  - 0 (Anabolic Agents)
RN  - 0 (Androgens)
RN  - 0 (Designer Drugs)
RN  - 0 (Performance-Enhancing Substances)
RN  - 0 (Steroids)
SB  - IM
MH  - Anabolic Agents/*analysis/chemistry/metabolism
MH  - Androgens/*analysis/chemistry/metabolism
MH  - Animals
MH  - Biotransformation
MH  - Chromatography, Liquid/*veterinary
MH  - Designer Drugs/*analysis/chemistry/metabolism
MH  - *Doping in Sports
MH  - Gas Chromatography-Mass Spectrometry/veterinary
MH  - Horses/*metabolism
MH  - In Vitro Techniques
MH  - Magnetic Resonance Spectroscopy
MH  - Mass Spectrometry/*veterinary
MH  - Microsomes, Liver/metabolism
MH  - Molecular Structure
MH  - Performance-Enhancing Substances/*analysis/chemistry/metabolism
MH  - Reproducibility of Results
MH  - Species Specificity
MH  - Steroids/*analysis/chemistry/metabolism
MH  - Substance Abuse Detection/*veterinary
EDAT- 2011/02/16 06:00
MHDA- 2011/05/13 06:00
CRDT- 2011/02/16 06:00
PHST- 2011/02/16 06:00 [entrez]
PHST- 2011/02/16 06:00 [pubmed]
PHST- 2011/05/13 06:00 [medline]
AID - 10.1002/dta.250 [doi]
PST - ppublish
SO  - Drug Test Anal. 2011 Jan;3(1):74-87. doi: 10.1002/dta.250.


PMID- 21322059
OWN - NLM
STAT- MEDLINE
DCOM- 20110809
LR  - 20211203
IS  - 1098-2353 (Electronic)
IS  - 0897-3806 (Linking)
VI  - 24
IP  - 4
DP  - 2011 May
TI  - The pattern of arrangement of the lumbrical muscles in an African population.
PG  - 423-8
LID - 10.1002/ca.21092 [doi]
AB  - The pattern of arrangement of the lumbrical muscles in the hand of an African
      population was studied. Sixty-four upper limb specimen from 32 male cadavers
      between the ages 18 and 40 were obtained from the Department of Anatomy,
      University of Calabar, Nigeria were used. Ethical approval was granted by the
      Ethics Committee of the University, and each of the limbs of the cadavers was
      labeled. Observations were grouped as A, B, C, D, and E and their incidence
      calculated using simple percentages. Group A constituted 50% and represented the 
      standard pattern. In this group, the first and second bellies of lumbrical
      muscles arose each from the radial sides of the corresponding flexor digitorum
      profundus (FDP) tendons, while the third and fourth bellies of the lumbrical
      muscles arose each from the contiguous sides of the FDP tendons of the middle and
      ring fingers, and the ring and little fingers, respectively. All the bellies were
      inserted to their corresponding sides in the radial part of the dorsal digital
      expansion. Groups B and E constituting 12.5 and 6.25%, respectively, presented
      single origins and insertions in all the four bellies of the lumbrical muscles.
      Groups C and D constituting 18.75 and 12.5%, respectively, showed double origins 
      in the third belly of the lumbrical muscle, with the first, second, and fourth
      having single origins. In conclusion, our study showed variations already
      reported, and peculiar pattern of lumbrical muscle arrangement in a single hand. 
      Therefore, this study is of anatomical, anthropological, and clinical importance.
CI  - Copyright (c) 2011 Wiley-Liss, Inc.
FAU - Igiri, Anozeng Oyono
AU  - Igiri AO
AD  - Department of Anatomy, University of Calabar, Calabar, Nigeria.
FAU - Mesembe, Otu Effiong
AU  - Mesembe OE
FAU - Ekong, Moses Bassey
AU  - Ekong MB
FAU - Akpan, Nsikak Ubong
AU  - Akpan NU
LA  - eng
PT  - Journal Article
DEP - 20110214
PL  - United States
TA  - Clin Anat
JT  - Clinical anatomy (New York, N.Y.)
JID - 8809128
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Blacks
MH  - Body Patterning
MH  - Cadaver
MH  - Hand/*anatomy & histology
MH  - Humans
MH  - Male
MH  - Muscle, Skeletal/*anatomy & histology
MH  - Young Adult
EDAT- 2011/02/16 06:00
MHDA- 2011/08/10 06:00
CRDT- 2011/02/16 06:00
PHST- 2008/11/08 00:00 [received]
PHST- 2010/07/21 00:00 [revised]
PHST- 2010/10/05 00:00 [accepted]
PHST- 2011/02/16 06:00 [entrez]
PHST- 2011/02/16 06:00 [pubmed]
PHST- 2011/08/10 06:00 [medline]
AID - 10.1002/ca.21092 [doi]
PST - ppublish
SO  - Clin Anat. 2011 May;24(4):423-8. doi: 10.1002/ca.21092. Epub 2011 Feb 14.


PMID- 21320763
OWN - NLM
STAT- MEDLINE
DCOM- 20120517
LR  - 20220408
IS  - 1872-7727 (Electronic)
IS  - 0720-048X (Linking)
VI  - 81
IP  - 2
DP  - 2012 Feb
TI  - Radiologic identification of disaster victims: a simple and reliable method using
      CT of the paranasal sinuses.
PG  - e132-8
LID - 10.1016/j.ejrad.2011.01.060 [doi]
AB  - OBJECTIVE: To assess the reliability of radiologic identification using visual
      comparison of ante and post mortem paranasal sinus computed tomography (CT).
      SUBJECTS AND METHODS: The study was approved by the responsible justice
      department and university ethics committee. Four blinded readers with varying
      radiological experience separately compared 100 post mortem to 25 ante mortem
      head CTs with the goal to identify as many matching pairs as possible (out of 23 
      possible matches). Sensitivity, specificity, positive and negative predictive
      values were calculated for all readers. The chi-square test was applied to
      establish if there was significant difference in sensitivity between radiologists
      and non-radiologists. RESULTS: For all readers, sensitivity was 83.7%,
      specificity was 100.0%, negative predictive value (NPV) was 95.4%, positive
      predictive value (PPV) was 100.0%, and accuracy was 96.3%. For radiologists,
      sensitivity was 97.8%, NPV was 99.4%, and accuracy was 99.5%. For
      non-radiologists, average sensitivity was 69.6%, negative predictive value (NPV) 
      was 91.7%, and accuracy was 93.0%. Radiologists achieved a significantly higher
      sensitivity (p < 0.01) than non-radiologists. CONCLUSIONS: Visual comparison of
      ante mortem and post mortem CT of the head is a robust and reliable method for
      identifying unknown decedents, particularly in regard to positive matches. The
      sensitivity and NPV of the method depend on the reader's experience.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Ruder, Thomas D
AU  - Ruder TD
AD  - Center for Forensic Imaging and Virtopsy, Institute of Forensic Medicine,
      University of Bern, Buehlstrasse 20, CH-3012 Bern, Switzerland.
      thomas.ruder@irm.unibe.ch
FAU - Kraehenbuehl, Markus
AU  - Kraehenbuehl M
FAU - Gotsmy, Walther F
AU  - Gotsmy WF
FAU - Mathier, Sandra
AU  - Mathier S
FAU - Ebert, Lars C
AU  - Ebert LC
FAU - Thali, Michael J
AU  - Thali MJ
FAU - Hatch, Gary M
AU  - Hatch GM
LA  - eng
PT  - Journal Article
DEP - 20110212
PL  - Ireland
TA  - Eur J Radiol
JT  - European journal of radiology
JID - 8106411
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biometric Identification/*methods
MH  - Child
MH  - Child, Preschool
MH  - *Disasters
MH  - Female
MH  - Forensic Anthropology/*methods
MH  - Humans
MH  - Infant
MH  - Male
MH  - Middle Aged
MH  - Paranasal Sinuses/*diagnostic imaging
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Single-Blind Method
MH  - Tomography, X-Ray Computed/*methods
MH  - Triage
MH  - Young Adult
EDAT- 2011/02/16 06:00
MHDA- 2012/05/18 06:00
CRDT- 2011/02/16 06:00
PHST- 2010/12/25 00:00 [received]
PHST- 2011/01/03 00:00 [accepted]
PHST- 2011/02/16 06:00 [entrez]
PHST- 2011/02/16 06:00 [pubmed]
PHST- 2012/05/18 06:00 [medline]
AID - S0720-048X(11)00089-1 [pii]
AID - 10.1016/j.ejrad.2011.01.060 [doi]
PST - ppublish
SO  - Eur J Radiol. 2012 Feb;81(2):e132-8. doi: 10.1016/j.ejrad.2011.01.060. Epub 2011 
      Feb 12.


PMID- 21320164
OWN - NLM
STAT- MEDLINE
DCOM- 20120522
LR  - 20111213
IS  - 1399-0012 (Electronic)
IS  - 0902-0063 (Linking)
VI  - 25
IP  - 6
DP  - 2011 Nov-Dec
TI  - Adult living-related liver donation for acute liver failure: is it ethically
      appropriate?
PG  - 813-20
LID - 10.1111/j.1399-0012.2011.01413.x [doi]
AB  - Acute liver failure (ALF) results in the annual death of approximately 3.5 per
      million people in the United States. Unfortunately, given the marked shortage of 
      cadaveric liver donations and the ethical questions that plague utilization of
      living donor liver transplantation (LDLT) for ALF, many patients with ALF die
      before a liver is allocated to them. In this review, we discuss how the
      consistent utilization of LDLT for ALF could decrease the mortality rate of ALF. 
      Additionally, we examine a key underlying issue: is LDLT for ALF ethically
      appropriate?
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Carlisle, Erica M
AU  - Carlisle EM
AD  - Department of Surgery, University of Chicago Medical Center, Chicago, IL 60637,
      USA.
FAU - Angelos, Peter
AU  - Angelos P
FAU - Siegler, Mark
AU  - Siegler M
FAU - Testa, Giuliano
AU  - Testa G
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110215
PL  - Denmark
TA  - Clin Transplant
JT  - Clinical transplantation
JID - 8710240
SB  - IM
MH  - Adult
MH  - Humans
MH  - Liver Failure, Acute/*therapy
MH  - Liver Transplantation/*ethics
MH  - Living Donors/*ethics
EDAT- 2011/02/16 06:00
MHDA- 2012/05/23 06:00
CRDT- 2011/02/16 06:00
PHST- 2011/02/16 06:00 [entrez]
PHST- 2011/02/16 06:00 [pubmed]
PHST- 2012/05/23 06:00 [medline]
AID - 10.1111/j.1399-0012.2011.01413.x [doi]
PST - ppublish
SO  - Clin Transplant. 2011 Nov-Dec;25(6):813-20. doi:
      10.1111/j.1399-0012.2011.01413.x. Epub 2011 Feb 15.


PMID- 21320146
OWN - NLM
STAT- MEDLINE
DCOM- 20130220
LR  - 20220311
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 26
IP  - 8
DP  - 2012 Oct
TI  - Against homeopathy--a utilitarian perspective.
PG  - 398-409
LID - 10.1111/j.1467-8519.2010.01876.x [doi]
AB  - I examine the positive and negative features of homeopathy from an ethical
      perspective. I consider: (a) several potentially beneficial features of
      homeopathy, including non-invasiveness, cost-effectiveness, holism, placebo
      benefits and agent autonomy; and (b) several potentially negative features of
      homeopathy, including failure to seek effective healthcare, wastage of resources,
      promulgation of false beliefs and a weakening of commitment to scientific
      medicine. A utilitarian analysis of the utilities and disutilities leads to the
      conclusion that homeopathy is ethically unacceptable and ought to be actively
      rejected by healthcare professionals.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Smith, Kevin
AU  - Smith K
AD  - Abertay University - Contemporary Sciences, Baxter Building, Dundee, Tayside DD1 
      1HG, UK. k.smith@abertay.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20110214
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
CIN - Bioethics. 2012 Nov;26(9):506-7; discussion 508-12. PMID: 22506605
CIN - Bioethics. 2012 Nov;26(9):501-3; discussion 508-12. PMID: 22506616
CIN - Bioethics. 2012 Nov;26(9):499-500; discussion 508-12. PMID: 22506658
CIN - Bioethics. 2012 Nov;26(9):504-5; discussion 508-12. PMID: 22506685
MH  - Attitude to Health
MH  - Biomedical Research
MH  - Cost-Benefit Analysis
MH  - Ethical Theory
MH  - Homeopathy/*ethics/statistics & numerical data
MH  - Humans
MH  - Personal Autonomy
MH  - Placebo Effect
EDAT- 2011/02/16 06:00
MHDA- 2013/02/21 06:00
CRDT- 2011/02/16 06:00
PHST- 2011/02/16 06:00 [entrez]
PHST- 2011/02/16 06:00 [pubmed]
PHST- 2013/02/21 06:00 [medline]
AID - 10.1111/j.1467-8519.2010.01876.x [doi]
PST - ppublish
SO  - Bioethics. 2012 Oct;26(8):398-409. doi: 10.1111/j.1467-8519.2010.01876.x. Epub
      2011 Feb 14.


PMID- 21320145
OWN - NLM
STAT- MEDLINE
DCOM- 20121112
LR  - 20191210
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 26
IP  - 6
DP  - 2012 Jul
TI  - 'Because we see them naked' - nurses' experiences in caring for hospitalized
      patients with dementia: considering artificial nutrition or hydration (ANH).
PG  - 285-95
LID - 10.1111/j.1467-8519.2010.01875.x [doi]
AB  - The aim of this study was to explore and describe how Flemish nurses experience
      their involvement in the care of hospitalized patients with dementia,
      particularly in relation to artificial nutrition or hydration (ANH). We
      interviewed 21 hospital nurses who were carefully selected from nine hospitals in
      different regions of Flanders. 'Being touched by the vulnerability of the
      demented patient' was the central experience of the nurses, having great impact
      on them professionally as well as personally. This feeling can be described as
      encompassing the various stages of the care process: the nurses' initial meeting 
      with the vulnerable patient; the intense decision-making process, during which
      the nurses experienced several intense emotions influenced by supporting or
      hindering contextual factors; and the final coping process, a time when nurses
      came to terms with this challenging experience. From our examination of this care
      process, it is obvious that nurses' involvement in ANH decision-making processes 
      that concern patients with dementia is a difficult and ethically sensitive
      experience. On the one hand, the feeling of 'being touched' can imply strength,
      as it demonstrates that nurses are willing to provide good care. On the other
      hand, the feeling of 'being touched' can also imply weakness, as it makes nurses 
      vulnerable to moral distress stemming from contextual influences. Therefore,
      nurses have to be supported as they carry out this ethically sensitive
      assignment. Practical implications are given.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Bryon, Els
AU  - Bryon E
AD  - Centre for Biomedical Ethics and Law, Centre for Health Services and Nursing
      Research, Catholic University of Leuven, Kapucijnenvoer 35/3, B-3000 Leuven,
      Belgium. els.bryon@med.kuleuven.be
FAU - Dierckx de Casterle, Bernadette
AU  - Dierckx de Casterle B
FAU - Gastmans, Chris
AU  - Gastmans C
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20110214
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Adult
MH  - Aged
MH  - Belgium
MH  - *Conflict, Psychological
MH  - Decision Making/*ethics
MH  - Dementia/*nursing
MH  - Emotions
MH  - Female
MH  - Fluid Therapy/*ethics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Narration
MH  - Nurse-Patient Relations/ethics
MH  - Nursing Staff, Hospital/*ethics/psychology
MH  - Nutritional Support/*ethics
MH  - Qualitative Research
EDAT- 2011/02/16 06:00
MHDA- 2012/11/13 06:00
CRDT- 2011/02/16 06:00
PHST- 2011/02/16 06:00 [entrez]
PHST- 2011/02/16 06:00 [pubmed]
PHST- 2012/11/13 06:00 [medline]
AID - 10.1111/j.1467-8519.2010.01875.x [doi]
PST - ppublish
SO  - Bioethics. 2012 Jul;26(6):285-95. doi: 10.1111/j.1467-8519.2010.01875.x. Epub
      2011 Feb 14.


PMID- 21320144
OWN - NLM
STAT- MEDLINE
DCOM- 20130529
LR  - 20121015
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 26
IP  - 9
DP  - 2012 Nov
TI  - Cluster randomization and political philosophy.
PG  - 476-84
LID - 10.1111/j.1467-8519.2010.01874.x [doi]
AB  - In this paper, I will argue that, while the ethical issues raised by cluster
      randomization can be challenging, they are not new. My thesis divides neatly into
      two parts. In the first, easier part I argue that many of the ethical challenges 
      posed by cluster randomized human subjects research are clearly present in other 
      types of human subjects research, and so are not novel. In the second, more
      difficult part I discuss the thorniest ethical challenge for cluster randomized
      research--cases where consent is genuinely impractical to obtain. I argue that
      once again these cases require no new analytic insight; instead, we should look
      to political philosophy for guidance. In other words, the most serious ethical
      problem that arises in cluster randomized research also arises in political
      philosophy.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Chwang, Eric
AU  - Chwang E
AD  - University of Colorado at Boulder, Boulder, CO 80309-0232, USA.
      chwang@colorado.edu
LA  - eng
PT  - Journal Article
DEP - 20110214
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Fluoridation/ethics
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Informed Consent/*ethics
MH  - *Philosophy
MH  - *Politics
MH  - Randomized Controlled Trials as Topic/*ethics
MH  - Social Justice
MH  - Taxes
MH  - United States
EDAT- 2011/02/16 06:00
MHDA- 2013/05/31 06:00
CRDT- 2011/02/16 06:00
PHST- 2011/02/16 06:00 [entrez]
PHST- 2011/02/16 06:00 [pubmed]
PHST- 2013/05/31 06:00 [medline]
AID - 10.1111/j.1467-8519.2010.01874.x [doi]
PST - ppublish
SO  - Bioethics. 2012 Nov;26(9):476-84. doi: 10.1111/j.1467-8519.2010.01874.x. Epub
      2011 Feb 14.


PMID- 21319437
OWN - NLM
STAT- MEDLINE
DCOM- 20110303
LR  - 20110214
IS  - 1546-3141 (Electronic)
IS  - 0361-803X (Linking)
VI  - 196
IP  - 2
DP  - 2011 Feb
TI  - Education in authorship ethics: should it be compulsory?
PG  - 235-6
FAU - Dighe, Manjiri K
AU  - Dighe MK
AD  - University of Washington Seattle, WA, USA.
FAU - Berquist, Thomas H
AU  - Berquist TH
LA  - eng
PT  - Journal Article
PL  - United States
TA  - AJR Am J Roentgenol
JT  - AJR. American journal of roentgenology
JID - 7708173
SB  - IM
MH  - Authorship/*standards
MH  - *Editorial Policies
MH  - *Education, Continuing/organization & administration
MH  - Efficiency/classification
MH  - Ethics, Professional/*education
MH  - Health Knowledge, Attitudes, Practice
MH  - Information Science/*education
MH  - Professional Misconduct/ethics
MH  - Publishing/*ethics
MH  - Societies, Medical
EDAT- 2011/02/16 06:00
MHDA- 2011/03/04 06:00
CRDT- 2011/02/16 06:00
PHST- 2011/02/16 06:00 [entrez]
PHST- 2011/02/16 06:00 [pubmed]
PHST- 2011/03/04 06:00 [medline]
AID - 10.2214/AJR.10.6121 [doi]
PST - ppublish
SO  - AJR Am J Roentgenol. 2011 Feb;196(2):235-6. doi: 10.2214/AJR.10.6121.


PMID- 21309898
OWN - NLM
STAT- MEDLINE
DCOM- 20110517
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 39 Suppl 1
DP  - 2011 Mar
TI  - Protecting the mental health of first responders: legal and ethical
      considerations.
PG  - 56-9
LID - 10.1111/j.1748-720X.2011.00567.x [doi]
FAU - Rutkow, Lainie
AU  - Rutkow L
AD  - Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
FAU - Gable, Lance
AU  - Gable L
FAU - Links, Jonathan M
AU  - Links JM
LA  - eng
GR  - 5P01TP000288-02/TP/OPHPR CDC HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Confidentiality
MH  - Humans
MH  - Mass Screening
MH  - Mental Health Services/*organization & administration
MH  - Occupational Diseases/*prevention & control
MH  - *Relief Work
MH  - *Rescue Work
MH  - Stress Disorders, Post-Traumatic/*prevention & control
MH  - United States
MH  - Workers' Compensation
EDAT- 2011/02/16 06:00
MHDA- 2011/05/18 06:00
CRDT- 2011/02/12 06:00
PHST- 2011/02/12 06:00 [entrez]
PHST- 2011/02/16 06:00 [pubmed]
PHST- 2011/05/18 06:00 [medline]
AID - 10.1111/j.1748-720X.2011.00567.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2011 Mar;39 Suppl 1:56-9. doi:
      10.1111/j.1748-720X.2011.00567.x.


PMID- 21319307
OWN - NLM
STAT- MEDLINE
DCOM- 20110329
LR  - 20110214
IS  - 1934-662X (Print)
IS  - 1934-662X (Linking)
VI  - 119
IP  - 1
DP  - 2011 Feb 25
TI  - Small lesions, big dilemmas: earlier detection creates ethical questions.
PG  - 1-2
LID - 10.1002/cncy.20137 [doi]
FAU - Nelson, Bryn
AU  - Nelson B
LA  - eng
PT  - News
PL  - United States
TA  - Cancer Cytopathol
JT  - Cancer cytopathology
JID - 101499453
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Diagnostic Imaging
MH  - *Ethics, Medical
MH  - Humans
MH  - Neoplasms/*diagnosis
MH  - Physicians/ethics/*psychology
EDAT- 2011/02/15 06:00
MHDA- 2011/03/30 06:00
CRDT- 2011/02/15 06:00
PHST- 2011/02/15 06:00 [entrez]
PHST- 2011/02/15 06:00 [pubmed]
PHST- 2011/03/30 06:00 [medline]
AID - 10.1002/cncy.20137 [doi]
PST - ppublish
SO  - Cancer Cytopathol. 2011 Feb 25;119(1):1-2. doi: 10.1002/cncy.20137.


PMID- 21318596
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20211020
IS  - 2629-3277 (Electronic)
IS  - 2629-3277 (Linking)
VI  - 7
IP  - 3
DP  - 2011 Sep
TI  - Application of iPS in assisted reproductive technology: sperm from somatic cells?
PG  - 714-21
LID - 10.1007/s12015-011-9236-8 [doi]
AB  - Infertility is an emotionally charged problem, and it is a condition of
      increasing incidence. In addition, in 40% to 60% of all infertile couples, it was
      the male who had a problem that led to infertility. Among the male fertility
      problems, non-obstructive azoospermia (NOA) (caused by testis failure or impaired
      spermatogenesis) is the most prevalent. Despite enormous clinical and
      experimental efforts, treatment of this disorder--assistant reproduction
      technique (ART) with donor spermatozoa remains controversial. We present the
      hypothesis that induced pluripotent stem (iPS) cell derived spermatozoa can be a 
      potential source for male gametes for patients with NOA; we support this with the
      following three evidence: the first is the generation of viable, live-born,
      fertile mature organism from iPS cells; the second is the successful induced
      differentiation of male gametes from pluripotent cells in vitro; and the last is 
      the wide use of intracytoplasmic sperm injection (ICSI) in human assisted
      reproduction. If the hiPS derived spermatozoa prove practical in the generation
      offspring with ICSI, this method might be able to grant a new chance for NOA
      patients to have their genetic children with fewer emotional, ethical and
      legislative problems. To ensure the safety of the technology itself and the
      production of healthy offspring, further investigations are needed. We also
      suggest several laboratory and clinical approaches for testing our hypothesis.
FAU - Yao, Lin
AU  - Yao L
AD  - Changhai Hospital, Second Military Medical University, 168 Changhai Road,
      Shanghai, China. liushanrong@hotmail.com
FAU - Yu, Xiya
AU  - Yu X
FAU - Hui, Ning
AU  - Hui N
FAU - Liu, Shanrong
AU  - Liu S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Stem Cell Rev Rep
JT  - Stem cell reviews and reports
JID - 101752767
SB  - IM
MH  - Animals
MH  - Female
MH  - Humans
MH  - Induced Pluripotent Stem Cells/cytology/*physiology
MH  - Infertility, Male/*therapy
MH  - Male
MH  - *Reproductive Techniques, Assisted
MH  - Spermatozoa/cytology/*physiology
EDAT- 2011/02/15 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/02/15 06:00
PHST- 2011/02/15 06:00 [entrez]
PHST- 2011/02/15 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - 10.1007/s12015-011-9236-8 [doi]
PST - ppublish
SO  - Stem Cell Rev Rep. 2011 Sep;7(3):714-21. doi: 10.1007/s12015-011-9236-8.


PMID- 21318325
OWN - NLM
STAT- MEDLINE
DCOM- 20131122
LR  - 20121204
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 18
IP  - 4
DP  - 2012 Dec
TI  - A plea for judgment.
PG  - 789-808
LID - 10.1007/s11948-011-9254-6 [doi]
AB  - Judgment is central to engineering, medicine, the sciences and many other
      practical activities. For example, one who otherwise knows what engineers know
      but lacks "engineering judgment" may be an expert of sorts, a handy resource much
      like a reference book or database, but cannot be a competent engineer. Though
      often overlooked or at least passed over in silence, the central place of
      judgment in engineering, the sciences, and the like should be obvious once
      pointed out. It is important here because it helps to explain where ethics fits
      into these disciplines. There is no good engineering, no good science, and so on 
      without good judgment and no good judgment in these disciplines without ethics.
      Doing even a minimally decent job of teaching one of these disciplines
      necessarily includes teaching its ethics; teaching the ethics is teaching the
      discipline (or at least a large part of it).
FAU - Davis, Michael
AU  - Davis M
AD  - Humanities Department, Senior Fellow, Center for the Study of Ethics in the
      Professions, Illinois Institute of Technology, Chicago, IL 60615, USA.
      davism@iit.edu
LA  - eng
PT  - Journal Article
DEP - 20110213
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Decision Making/*ethics
MH  - Engineering/*ethics
MH  - *Ethics, Medical
MH  - Humans
MH  - Judgment/*ethics
MH  - *Professional Competence
MH  - Science/*ethics
MH  - Teaching
EDAT- 2011/02/15 06:00
MHDA- 2013/12/16 06:00
CRDT- 2011/02/15 06:00
PHST- 2010/08/22 00:00 [received]
PHST- 2011/01/24 00:00 [accepted]
PHST- 2011/02/15 06:00 [entrez]
PHST- 2011/02/15 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1007/s11948-011-9254-6 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2012 Dec;18(4):789-808. doi: 10.1007/s11948-011-9254-6. Epub 2011
      Feb 13.


PMID- 21318324
OWN - NLM
STAT- MEDLINE
DCOM- 20120919
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 18
IP  - 2
DP  - 2012 Jun
TI  - ABET Criterion 3.f: how much curriculum content is enough?
PG  - 369-92
LID - 10.1007/s11948-011-9255-5 [doi]
AB  - Even after multiple cycles of ABET accreditation, many engineering programs are
      unsure of how much curriculum content is needed to meet the requirements of
      ABET's Criterion 3.f (an understanding of professional and ethical
      responsibility). This study represents the first scholarly attempt to assess the 
      impact of curriculum reform following the introduction of ABET Criterion 3.f.
      This study sought to determine how much professional and ethical responsibility
      curriculum content was used between 1995 and 2005, as well as how, when, why, and
      to what effect changes in the amount of content occurred. Subsequently, the study
      sought to evaluate if different amounts of curriculum content generated differing
      student outcomes. The amount of curriculum content used by each of the
      participating programs was identified during semi-structured interviews with
      program administrators and a review of ABET Self-Study documents. Quantitative
      methods were applied to determine if a relationship existed between the
      curriculum content and performance on a nationally administered,
      engineering-specific standardized examination. The findings indicate a
      statistical relationship, but a lack of structure between the amount of required 
      content in the curriculum and performance on the examination. Additional findings
      were also generated regarding the way that programs interpret the Criterion 3.f
      feedback generated during accreditation visits. The primary impact of this study 
      is that it dispels the myth that more courses or course time on professionalism
      and ethics will necessarily lead to positive engineering education outcomes. Much
      of the impetus to add more curriculum content results from a lack of conclusive
      feedback during ABET accreditation visits.
FAU - Barry, B E
AU  - Barry BE
AD  - Department of Civil and Mechanical Engineering, United States Military Academy,
      Bldg. 752 Mahan Hall, West Point, NY, 10996, USA. brock.barry@usma.edu
FAU - Ohland, M W
AU  - Ohland MW
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20110212
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Accreditation
MH  - Curriculum/*standards
MH  - Educational Measurement/*standards
MH  - Engineering/*education/ethics
MH  - Ethics, Professional/*education
MH  - Feedback
MH  - *Guidelines as Topic
MH  - Humans
MH  - Interviews as Topic
MH  - *Program Evaluation
EDAT- 2011/02/15 06:00
MHDA- 2012/09/20 06:00
CRDT- 2011/02/15 06:00
PHST- 2010/09/01 00:00 [received]
PHST- 2011/01/24 00:00 [accepted]
PHST- 2011/02/15 06:00 [entrez]
PHST- 2011/02/15 06:00 [pubmed]
PHST- 2012/09/20 06:00 [medline]
AID - 10.1007/s11948-011-9255-5 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2012 Jun;18(2):369-92. doi: 10.1007/s11948-011-9255-5. Epub 2011 
      Feb 12.


PMID- 21318323
OWN - NLM
STAT- MEDLINE
DCOM- 20120919
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 18
IP  - 2
DP  - 2012 Jun
TI  - Publication ethics from the perspective of PhD students of health sciences: a
      limited experience.
PG  - 213-22
LID - 10.1007/s11948-011-9256-4 [doi]
AB  - Publication ethics, an important subtopic of science ethics, deals with
      determination of the misconducts of science in performing research or in the
      dissemination of ideas, data and products. Science, the main features of which
      are secure, reliable and ethically obtained data, plays a major role in shaping
      the society. As long as science maintains its quality by being based on reliable 
      and ethically obtained data, it will be possible to maintain its role in shaping 
      the society. This article is devoted to the presentation of opinions of PhD
      candidate students in health sciences in Ankara concerning publication ethics.
      The data obtained from 143 PhD students from the fields of medicine, dentistry,
      pharmacy and veterinary reveal limited but unique experiences. It also shows that
      plagiarism is one of the worst issues in the publication ethics from the
      perspective of these young academics.
FAU - Arda, Berna
AU  - Arda B
AD  - Deontology, Medical Ethics Department, Ankara University School of Medicine,
      Sihhiye, 06100, Ankara, Turkey. arda@medicine.ankara.edu.tr
LA  - eng
PT  - Journal Article
DEP - 20110212
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Education, Medical, Graduate
MH  - *Ethics, Research
MH  - Female
MH  - Humans
MH  - Information Dissemination/*ethics
MH  - Male
MH  - *Plagiarism
MH  - Publishing/*ethics
MH  - Science/*ethics
MH  - *Students
EDAT- 2011/02/15 06:00
MHDA- 2012/09/20 06:00
CRDT- 2011/02/15 06:00
PHST- 2009/06/30 00:00 [received]
PHST- 2011/01/28 00:00 [accepted]
PHST- 2011/02/15 06:00 [entrez]
PHST- 2011/02/15 06:00 [pubmed]
PHST- 2012/09/20 06:00 [medline]
AID - 10.1007/s11948-011-9256-4 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2012 Jun;18(2):213-22. doi: 10.1007/s11948-011-9256-4. Epub 2011 
      Feb 12.


PMID- 21318321
OWN - NLM
STAT- MEDLINE
DCOM- 20120919
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 18
IP  - 2
DP  - 2012 Jun
TI  - Framing ethical acceptability: a problem with nuclear waste in Canada.
PG  - 301-13
LID - 10.1007/s11948-011-9262-6 [doi]
AB  - Ethical frameworks are often used in professional fields as a means of providing 
      explicit ethical guidance for individuals and institutions when confronted with
      ethically important decisions. The notion of an ethical framework has received
      little critical attention, however, and the concept subsequently lends itself
      easily to misuse and ambiguous application. This is the case with the 'ethical
      framework' offered by Canada's Nuclear Waste Management Organization (NWMO), the 
      crown-corporation which owns and is responsible for the long-term management of
      Canada's high-level nuclear fuel waste. It makes a very specific claim, namely
      that it is managing Canada's long-lived radioactive nuclear fuel waste in an
      ethically responsible manner. According to this organization, what it means to
      behave in an ethically responsible manner is to act and develop policy in
      accordance with its ethical framework. What, then, is its ethical framework, and 
      can it be satisfied? In this paper I will show that the NWMO's ethical and social
      framework is deeply flawed in two respects: (a) it fails to meet the minimum
      requirements of a code of ethic or ethical framework by offering only questions, 
      and no principles or rules of conduct; and (b) if posed as principles or rules of
      conduct, some of its questions are unsatisfiable. In particular, I will show that
      one of its claims, namely that it seek informed consent from individuals exposed 
      to risk of harm from nuclear waste, cannot be satisfied as formulated. The result
      is that the NWMO's ethical framework is not, at present, ethically acceptable.
FAU - Wilding, Ethan T
AU  - Wilding ET
AD  - Philosophy Department, University of Waterloo, 200 University Ave W., Waterloo,
      ON, N2L 3G1, Canada. ethan.wilding@uwaterloo.ca
LA  - eng
PT  - Journal Article
DEP - 20110212
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
RN  - 0 (Radioactive Waste)
SB  - IM
MH  - Canada
MH  - *Codes of Ethics
MH  - Environmental Exposure/*ethics
MH  - *Ethics, Business
MH  - *Guidelines as Topic
MH  - Humans
MH  - Informed Consent/ethics
MH  - Policy
MH  - Radioactive Waste/*ethics
MH  - *Social Responsibility
MH  - Waste Management/*ethics
EDAT- 2011/02/15 06:00
MHDA- 2012/09/20 06:00
CRDT- 2011/02/15 06:00
PHST- 2010/09/23 00:00 [received]
PHST- 2011/01/31 00:00 [accepted]
PHST- 2011/02/15 06:00 [entrez]
PHST- 2011/02/15 06:00 [pubmed]
PHST- 2012/09/20 06:00 [medline]
AID - 10.1007/s11948-011-9262-6 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2012 Jun;18(2):301-13. doi: 10.1007/s11948-011-9262-6. Epub 2011 
      Feb 12.


PMID- 21318320
OWN - NLM
STAT- MEDLINE
DCOM- 20120109
LR  - 20211020
IS  - 1573-7373 (Electronic)
IS  - 0167-594X (Linking)
VI  - 104
IP  - 3
DP  - 2011 Sep
TI  - Competing for patients: an ethical framework for recruiting patients with brain
      tumors into clinical trials.
PG  - 623-7
LID - 10.1007/s11060-011-0536-2 [doi]
AB  - With more rapid advances in potential treatments for brain tumours, the number of
      clinical trials for brain tumour patients is rising. In the context of the
      challenges of recruitment and enrollment of patients with brain tumors, the
      dichotomy between the paucity of subjects and abundance of clinical trials
      creates a unique ethical dilemma, whereby a single patient may be eligible for
      several studies. Here, we identify and present three approaches for recruiting
      and enrolling patients who may be eligible for several trials. The ethical
      implications of the full disclosure, paternalistic, and random approaches are
      discussed. The full disclosure approach presents information to patients
      regarding all ongoing concurrent trials, allowing them to make an informed
      decision, while the paternalistic approach allows the healthcare providers to
      select the trial for which they believe the patient is most suitable. These
      introduce the biases into circumstances where equipoise is necessary and risk
      selection bias in study design. The random approach randomly allocates patients
      to each trial, which may erode patient autonomy and decrease trial enrollment.
      Brain tumor patients comprise a vulnerable population and it remains incumbent on
      healthcare providers to maintain the highest ethical standards when approaching
      them for clinical research. Changes in clinical trial design are required to
      mitigate the conflicts created by competition for patients.
FAU - Ibrahim, George M
AU  - Ibrahim GM
FAU - Chung, Caroline
AU  - Chung C
FAU - Bernstein, Mark
AU  - Bernstein M
LA  - eng
PT  - Editorial
DEP - 20110212
PL  - United States
TA  - J Neurooncol
JT  - Journal of neuro-oncology
JID - 8309335
SB  - IM
MH  - Biomedical Research/ethics/methods
MH  - Brain Neoplasms/*therapy
MH  - Clinical Trials as Topic/*ethics
MH  - Humans
MH  - Patient Selection/*ethics
EDAT- 2011/02/15 06:00
MHDA- 2012/01/10 06:00
CRDT- 2011/02/15 06:00
PHST- 2010/12/05 00:00 [received]
PHST- 2011/01/31 00:00 [accepted]
PHST- 2011/02/15 06:00 [entrez]
PHST- 2011/02/15 06:00 [pubmed]
PHST- 2012/01/10 06:00 [medline]
AID - 10.1007/s11060-011-0536-2 [doi]
PST - ppublish
SO  - J Neurooncol. 2011 Sep;104(3):623-7. doi: 10.1007/s11060-011-0536-2. Epub 2011
      Feb 12.


PMID- 21317441
OWN - NLM
STAT- MEDLINE
DCOM- 20110418
LR  - 20200219
IS  - 2561-8741 (Electronic)
IS  - 2561-8741 (Linking)
VI  - 18
IP  - 1
DP  - 2011
TI  - A survey of Canadian medical student attitudes towards the ethics of pediatric
      clinical trials: are they different from Canadian and British health care
      professionals?
PG  - e10-6
AB  - BACKGROUND: Due to ethical concerns and constraints inherent to research in
      children, the conduct of clinical trials in children has often been difficult.
      The views of medical professionals and trainees towards conducting clinical
      trials in children have been largely unexplored and are potentially important
      towards working to increase the number of appropriate trials conducted in
      children. OBJECTIVE: To explore the views of Canadian medical school trainees
      towards paediatric clinical trials and to compare these views with that of an
      earlier pilot study conducted amongst Canadian and British health care
      professionals. METHODS: Participants were given a questionnaire which consisted
      of direct questions as well as scenarios with ethical dilemmas. Responders were
      asked to state whether they would enter children in the trial documented in the
      scenario and to justify their reasons. RESULTS: 89 questionnaires were collected 
      (74% response rate). 42% had formal teaching regarding paediatric ethical
      dilemmas but only 2% had formal teaching on pharmaceutical testing in children.
      The students were divided on whether children should only participate in trials
      where they receive direct benefit. Most students (85%; 95% CI: 77% to 91%) were
      comfortable with non-inferiority trials even with post-hoc consent. Only a third 
      (33%; 95% CI: 24% to 43%) agreed with the use of placebo in an analgesia trial.
      CONCLUSION: Teaching on the ethics of paediatric clinical trials still appears to
      be lacking amongst medical trainees. However, there does seem to be increased
      willingness on the part of trainees compared to practicing medical professionals 
      in enrolling children in clinical trials.
FAU - Wang, Dianna
AU  - Wang D
AD  - School of Medicine and Dentistry, University of Western Ontario, London, Ontario,
      Canada.
FAU - Bahm, Allison L
AU  - Bahm AL
FAU - Seabrook, Jamie A
AU  - Seabrook JA
FAU - Sammons, Helen M
AU  - Sammons HM
FAU - Rieder, Michael J
AU  - Rieder MJ
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110128
PL  - Australia
TA  - J Popul Ther Clin Pharmacol
JT  - Journal of population therapeutics and clinical pharmacology = Journal de la
      therapeutique des populations et de la pharmacologie clinique
JID - 101530023
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Canada
MH  - Child
MH  - Clinical Trials as Topic/*ethics
MH  - Female
MH  - Humans
MH  - Male
MH  - *Pediatrics
MH  - *Students, Medical
MH  - Surveys and Questionnaires
MH  - United Kingdom
EDAT- 2011/02/15 06:00
MHDA- 2011/04/19 06:00
CRDT- 2011/02/15 06:00
PHST- 2011/02/15 06:00 [entrez]
PHST- 2011/02/15 06:00 [pubmed]
PHST- 2011/04/19 06:00 [medline]
PST - ppublish
SO  - J Popul Ther Clin Pharmacol. 2011;18(1):e10-6. Epub 2011 Jan 28.


PMID- 21317432
OWN - NLM
STAT- MEDLINE
DCOM- 20110711
LR  - 20131121
IS  - 1468-2044 (Electronic)
IS  - 0003-9888 (Linking)
VI  - 96
IP  - 6
DP  - 2011 Jun
TI  - Networking in paediatrics: the example of the Paediatric Rheumatology
      International Trials Organisation (PRINTO).
PG  - 596-601
LID - 10.1136/adc.2010.188946 [doi]
AB  - Networking is key to overcoming the logistical, methodological and ethical
      problems related to the implementation of paediatric studies. The adoption of
      legislation to encourage paediatric clinical trials by the American and European 
      regulatory agencies has opened a new era in the assessment of drug safety and
      efficacy in children. Two very large international trial networks--the Pediatric 
      Rheumatology Collaborative Study Group (PRCSG) and the Paediatric Rheumatology
      International Trials Organisation (PRINTO)--have played a critical role in the
      implementation of this legislation and have facilitated several successful
      controlled studies on the safety and the efficacy of new and old drugs in
      paediatric rheumatic diseases. The PRINTO and PRCSG networks can be seen as a
      model for international co-operation in other paediatric subspecialties.
FAU - Ruperto, Nicolino
AU  - Ruperto N
AD  - Pediatria II, Reumatologia, University of Genoa, EULAR Centre of Excellence in
      Rheumatology 2008-13, IRCCS G Gaslini, Largo G Gaslini 5, Genoa, Italy.
FAU - Martini, Alberto
AU  - Martini A
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110212
PL  - England
TA  - Arch Dis Child
JT  - Archives of disease in childhood
JID - 0372434
RN  - 0 (Antirheumatic Agents)
SB  - IM
MH  - Antirheumatic Agents/therapeutic use
MH  - Arthritis, Juvenile/drug therapy
MH  - Biomedical Research/organization & administration
MH  - Child
MH  - Controlled Clinical Trials as Topic/*methods
MH  - Humans
MH  - *International Cooperation
MH  - Pediatrics/*organization & administration
MH  - Rheumatology/*organization & administration
EDAT- 2011/02/15 06:00
MHDA- 2011/07/12 06:00
CRDT- 2011/02/15 06:00
PHST- 2011/02/15 06:00 [entrez]
PHST- 2011/02/15 06:00 [pubmed]
PHST- 2011/07/12 06:00 [medline]
AID - adc.2010.188946 [pii]
AID - 10.1136/adc.2010.188946 [doi]
PST - ppublish
SO  - Arch Dis Child. 2011 Jun;96(6):596-601. doi: 10.1136/adc.2010.188946. Epub 2011
      Feb 12.


PMID- 21316938
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20191210
IS  - 1532-2963 (Electronic)
IS  - 0958-2592 (Linking)
VI  - 21
IP  - 3
DP  - 2011 Sep
TI  - A longitudinal study of hallux valgus surgical outcomes using a validated patient
      centred outcome measure.
PG  - 133-7
LID - 10.1016/j.foot.2011.01.012 [doi]
AB  - BACKGROUND: Hallux valgus is a common chronic condition affecting up to a third
      of the population. Progressive disruption to the complex anatomy of the first ray
      involving metatarsal, sesamoids and hallux impose both structural and functional 
      alteration to the foot which underpin the secondary pathologies associated with
      this condition. It is common for patients to seek correction of the deformity in 
      order to alleviate pain and improve footwear tolerance. Surgical intervention
      remains the only viable means to restore osseous alignments. To date there
      remains no universally accepted standards for procedure selection. METHODS: A
      total of 179 consecutive participants were recruited into the study. Ethical
      approval was obtained and all participants consented to participate in the study,
      in accordance with the Helsinki Declaration. All patients attending the
      Department of Podiatric Surgery, between July 2004 and October 2007 for the
      surgical management of hallux valgus were invited to complete a Foot Health
      Status Questionnaire. Pre-operative data collection on all participants was
      undertaken on the day of admission, using the validated Foot Health Status
      Questionnaire measurement tool as with previous studies. RESULTS: A total of 179 
      complete data sets were recorded in this longitudinal study with an average
      participant age of 49.4 years (SD 14.5). The group comprised 164 females and 15
      males. The mean days for administration of the Foot Health Status Questionnaire
      post operative follow up was 1045 days (149 weeks or 2.9 years). The results
      demonstrated that within all four foot specific domains, the minimal important
      differences were achieved by the majority of the group. Meanwhile, in domains
      relating to general health, physical activity, vigour and social capacity, the
      majority of participants failed to attain the calculated minimal important
      difference (94 [53%], 96 [54%], 93 [52%], 93 [52%], respectively). CONCLUSIONS:
      The authors have presented for the first time minimal important difference for
      all eight domains for the Foot Health Status Questionnaire quality of life tool
      in respect to hallux valgus surgery. Results demonstrate that surgical correction
      of hallux valgus undertaken under local anaesthetic as a Day Case procedure is an
      effective intervention directly benefiting patients by reducing perceived foot
      pain, improving foot function and general foot health for the majority of
      patients.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Spruce, Michelle C
AU  - Spruce MC
AD  - School of Health Sciences, University of Southampton, Highfield Campus,
      Southampton, UK. mcs2@soton.ac.uk
FAU - Bowling, Frank L
AU  - Bowling FL
FAU - Metcalfe, Stuart A
AU  - Metcalfe SA
LA  - eng
PT  - Journal Article
DEP - 20110212
PL  - Scotland
TA  - Foot (Edinb)
JT  - Foot (Edinburgh, Scotland)
JID - 9109564
SB  - IM
MH  - Female
MH  - Hallux Valgus/*surgery
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - *Outcome Assessment, Health Care
MH  - *Quality of Life
MH  - *Surveys and Questionnaires
EDAT- 2011/02/15 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/02/15 06:00
PHST- 2010/11/08 00:00 [received]
PHST- 2011/01/12 00:00 [revised]
PHST- 2011/01/14 00:00 [accepted]
PHST- 2011/02/15 06:00 [entrez]
PHST- 2011/02/15 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - S0958-2592(11)00013-7 [pii]
AID - 10.1016/j.foot.2011.01.012 [doi]
PST - ppublish
SO  - Foot (Edinb). 2011 Sep;21(3):133-7. doi: 10.1016/j.foot.2011.01.012. Epub 2011
      Feb 12.


PMID- 21316172
OWN - NLM
STAT- MEDLINE
DCOM- 20120619
LR  - 20161125
IS  - 1872-7727 (Electronic)
IS  - 0720-048X (Linking)
VI  - 81
IP  - 3
DP  - 2012 Mar
TI  - Demonstration of the dorsal pancreatic artery by CTA to facilitate superselective
      arterial infusion of stem cells into the pancreas.
PG  - 461-5
LID - 10.1016/j.ejrad.2010.12.077 [doi]
AB  - PURPOSE: To investigate the diagnostic performance of 64-section CTA in the
      detection of dorsal pancreatic artery before interventional therapy for patients 
      with diabetes. MATERIALS AND METHODS: The study was approved by the institutional
      ethics committee; written informed consent was obtained. Forty-two consecutive
      patients with diabetes received an experimental treatment of autologous bone
      marrow-derived stem cell transplantation by means of infusion into the dorsal
      pancreatic artery. All cases underwent abdominal CTA before angiography of
      pancreatic arteries in order to locate the origin and course of dorsal pancreatic
      artery. Angiography of coeliac artery, splenic artery, common hepatic artery and 
      superior mesenteric artery were performed both in CTA and DSA. Superselective
      catheterization of dorsal pancreatic artery was carried out for the infusion of
      stem cell. Sensitivity, specificity and accuracy for the detection of dorsal
      pancreatic artery with CTA were calculated using DSA images as the reference
      standard. RESULTS: Thirty-five and thirty-six dorsal pancreatic arteries were
      detected by CTA and DSA respectively. Dorsal pancreatic artery was not visualized
      in either CTA or DSA in 5 patients. The sensitivity, specificity and accuracy for
      CTA were 94.4%, 83.3% and 92.9%. CONCLUSION: 64-section CTA is accurate for the
      detection of dorsal pancreatic artery. It may be useful for the facilitation of
      superselective arterial infusion of stem cells to pancreas.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Lin, Yuning
AU  - Lin Y
AD  - Department of Medical Imaging, Fuzhou General Hospital of Nanjing Military Area
      Command of Chinese PLA, Fuzhou 350025, Fujian Province, China. linyn911@163.com
FAU - Yang, Xizhang
AU  - Yang X
FAU - Chen, Ziqian
AU  - Chen Z
FAU - Tan, Jianming
AU  - Tan J
FAU - Zhong, Qun
AU  - Zhong Q
FAU - Yang, Li
AU  - Yang L
FAU - Wu, Zhixian
AU  - Wu Z
LA  - eng
PT  - Journal Article
DEP - 20110211
PL  - Ireland
TA  - Eur J Radiol
JT  - European journal of radiology
JID - 8106411
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Angiography, Digital Subtraction/*methods
MH  - Celiac Artery/diagnostic imaging
MH  - Diabetes Mellitus/diagnostic imaging/therapy
MH  - Female
MH  - Hepatic Artery/diagnostic imaging
MH  - Humans
MH  - Infusions, Intra-Arterial
MH  - Male
MH  - Mesenteric Artery, Superior/diagnostic imaging
MH  - Middle Aged
MH  - Pancreas/*blood supply/*diagnostic imaging
MH  - Radiographic Image Interpretation, Computer-Assisted
MH  - Radiography, Abdominal
MH  - Sensitivity and Specificity
MH  - Splenic Artery/diagnostic imaging
MH  - Stem Cell Transplantation/methods
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2011/02/15 06:00
MHDA- 2012/06/20 06:00
CRDT- 2011/02/15 06:00
PHST- 2010/09/05 00:00 [received]
PHST- 2010/12/16 00:00 [revised]
PHST- 2010/12/28 00:00 [accepted]
PHST- 2011/02/15 06:00 [entrez]
PHST- 2011/02/15 06:00 [pubmed]
PHST- 2012/06/20 06:00 [medline]
AID - S0720-048X(11)00026-X [pii]
AID - 10.1016/j.ejrad.2010.12.077 [doi]
PST - ppublish
SO  - Eur J Radiol. 2012 Mar;81(3):461-5. doi: 10.1016/j.ejrad.2010.12.077. Epub 2011
      Feb 11.


PMID- 21315123
OWN - NLM
STAT- MEDLINE
DCOM- 20110920
LR  - 20220408
IS  - 1095-8304 (Electronic)
IS  - 0195-6663 (Linking)
VI  - 56
IP  - 3
DP  - 2011 Jun
TI  - Replacement of meat by meat substitutes. A survey on person- and product-related 
      factors in consumer acceptance.
PG  - 662-73
LID - 10.1016/j.appet.2011.02.001 [doi]
AB  - What does it take to increase the consumption of meat substitutes and attract new
      consumers? We identified main barriers and drivers by a consumer survey (n=553)
      in the U.K. and the Netherlands. Person-related factors (food neophobia and food 
      choice motives) and product-related attitudes and beliefs towards meat and meat
      substitutes were compared between non-users (n=324), light/medium-users (n=133)
      and heavy-users of meat substitutes (n=96). Consumer acceptance was largely
      determined by the attitudes and beliefs towards meat substitutes and food
      neophobia. Key barriers for non-users and light/medium-users were the
      unfamiliarity with meat substitutes and the lower sensory attractiveness compared
      to meat. In addition, non-users had a higher tendency to avoid new foods. Hence, 
      the less consumers were using meat substitutes, the more they wanted these
      products to be similar to meat. Although non-users and light/medium-users did
      recognize the ethical and weight-control aspects of meat substitutes, this was
      obviously less relevant to them. Actually, only heavy-users had high motivations 
      to choose ethical foods, which explains their choice for meat substitutes. In
      order to make meat substitutes more attractive to meat consumers, we would not
      recommend to focus on communication of ethical arguments, but to significantly
      improve the sensory quality and resemblance to meat.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Hoek, Annet C
AU  - Hoek AC
AD  - Division of Human Nutrition, Wageningen University (Bode 62), P.O. Box 8129, 6700
      EV Wageningen, The Netherlands. annethoek@yahoo.co.uk
FAU - Luning, Pieternel A
AU  - Luning PA
FAU - Weijzen, Pascalle
AU  - Weijzen P
FAU - Engels, Wim
AU  - Engels W
FAU - Kok, Frans J
AU  - Kok FJ
FAU - de Graaf, Cees
AU  - de Graaf C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110217
PL  - England
TA  - Appetite
JT  - Appetite
JID - 8006808
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Attitude to Health
MH  - Choice Behavior/physiology
MH  - Consumer Behavior/*statistics & numerical data
MH  - Diet Surveys/*methods/statistics & numerical data
MH  - Diet, Vegetarian/statistics & numerical data
MH  - Food Preferences/physiology
MH  - Food, Formulated/*statistics & numerical data
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Male
MH  - *Meat
MH  - Netherlands
MH  - Socioeconomic Factors
MH  - Surveys and Questionnaires
MH  - United Kingdom
EDAT- 2011/02/15 06:00
MHDA- 2011/09/21 06:00
CRDT- 2011/02/15 06:00
PHST- 2009/08/30 00:00 [received]
PHST- 2010/12/16 00:00 [revised]
PHST- 2011/02/02 00:00 [accepted]
PHST- 2011/02/15 06:00 [entrez]
PHST- 2011/02/15 06:00 [pubmed]
PHST- 2011/09/21 06:00 [medline]
AID - S0195-6663(11)00052-3 [pii]
AID - 10.1016/j.appet.2011.02.001 [doi]
PST - ppublish
SO  - Appetite. 2011 Jun;56(3):662-73. doi: 10.1016/j.appet.2011.02.001. Epub 2011 Feb 
      17.


PMID- 21314796
OWN - NLM
STAT- MEDLINE
DCOM- 20110621
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 39
IP  - 1
DP  - 2011 Spring
TI  - Harmonization of ethics policies in pediatric research.
PG  - 70-8
LID - 10.1111/j.1748-720X.2011.00551.x [doi]
FAU - Blake, Valarie
AU  - Blake V
AD  - Pediatric Hematology/Oncology at Dana-Farber Cancer Institute (DFCI) and
      Children's Hospital in Boston, MA, USA.
FAU - Joffe, Steve
AU  - Joffe S
FAU - Kodish, Eric
AU  - Kodish E
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Child
MH  - *Ethics, Research
MH  - Europe
MH  - Humans
MH  - Pediatrics/*ethics
MH  - *Public Policy
MH  - United States
MH  - United States Food and Drug Administration
EDAT- 2011/02/15 06:00
MHDA- 2011/06/22 06:00
CRDT- 2011/02/15 06:00
PHST- 2011/02/15 06:00 [entrez]
PHST- 2011/02/15 06:00 [pubmed]
PHST- 2011/06/22 06:00 [medline]
AID - 10.1111/j.1748-720X.2011.00551.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2011 Spring;39(1):70-8. doi: 10.1111/j.1748-720X.2011.00551.x.


PMID- 21314068
OWN - NLM
STAT- MEDLINE
DCOM- 20110308
LR  - 20191027
IS  - 0037-8046 (Print)
IS  - 0037-8046 (Linking)
VI  - 56
IP  - 1
DP  - 2011 Jan
TI  - Alcohol treatment and cognitive-behavioral therapy: enhancing effectiveness by
      incorporating spirituality and religion.
PG  - 21-31
AB  - Cognitive-behavioral therapy (CBT) is an effective modality for the treatment of 
      alcoholism. Given widespread interest in incorporating spirituality into
      professional treatment, this article orients practitioners to spiritually
      modified CBT, an approach that may enhance outcomes with some spiritually
      motivated clients. More specifically, by integrating clients' spiritual beliefs
      and practices into treatment, this modality may speed recovery, enhance treatment
      compliance, prevent relapse, and reduce treatment disparities by providing more
      culturally congruent services. The process of constructing spiritually modified
      CBT self-statements is described and illustrated, and suggestions are provided
      for working with client spirituality in an ethical manner. The article concludes 
      by emphasizing the importance of this approach in light of the growing spiritual 
      diversity that characterizes contemporary society.
FAU - Hodge, David R
AU  - Hodge DR
AD  - School of Social Work, Arizona State University, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Soc Work
JT  - Social work
JID - 2984852R
SB  - IM
MH  - Alcoholism/psychology/*therapy
MH  - Cognitive Behavioral Therapy/*methods
MH  - Humans
MH  - Professional-Patient Relations
MH  - *Religion and Psychology
MH  - Secondary Prevention
EDAT- 2011/02/15 06:00
MHDA- 2011/03/09 06:00
CRDT- 2011/02/15 06:00
PHST- 2011/02/15 06:00 [entrez]
PHST- 2011/02/15 06:00 [pubmed]
PHST- 2011/03/09 06:00 [medline]
AID - 10.1093/sw/56.1.21 [doi]
PST - ppublish
SO  - Soc Work. 2011 Jan;56(1):21-31. doi: 10.1093/sw/56.1.21.


PMID- 21312052
OWN - NLM
STAT- MEDLINE
DCOM- 20110909
LR  - 20110523
IS  - 1572-8358 (Electronic)
IS  - 0001-5342 (Linking)
VI  - 59
IP  - 2
DP  - 2011 Jun
TI  - Concepts of animal welfare in relation to positions in animal ethics.
PG  - 153-71
LID - 10.1007/s10441-011-9128-y [doi]
AB  - When animal ethicists deal with welfare they seem to face a dilemma: On the one
      hand, they recognize the necessity of welfare concepts for their ethical
      approaches. On the other hand, many animal ethicists do not want to be considered
      reformist welfarists. Moreover, animal welfare scientists may feel pressed by
      moral demands for a fundamental change in our attitude towards animals. The
      analysis of this conflict from the perspective of animal ethics shows that animal
      welfare science and animal ethics highly depend on each other. Welfare concepts
      are indispensable in the whole field of animal ethics. Evidence for this can be
      found by analyzing the structure of theories of animal ethics and the different
      ways in which these theories employ welfare concepts. Furthermore, the background
      of values underneath every welfare theory is essential to pursue animal welfare
      science. Animal ethics can make important contributions to the clarification of
      underlying normative assumptions with regard to the value of the animal, with
      regard to ideas about what is valuable for the animal, and with regard to the
      actions that should follow from the results of animal welfare science.
FAU - Schmidt, Kirsten
AU  - Schmidt K
AD  - Institut fur Philosophie, Ruhr-Universitat Bochum, Germany.
      kirsten.schmidt@rub.de
LA  - eng
PT  - Journal Article
DEP - 20110211
PL  - Netherlands
TA  - Acta Biotheor
JT  - Acta biotheoretica
JID - 0421520
SB  - IM
MH  - Animal Experimentation/*ethics
MH  - Animal Rights
MH  - Animal Welfare/*ethics
MH  - Animals
MH  - Ethical Theory
MH  - Ethics
MH  - Humans
MH  - Models, Theoretical
MH  - Morals
MH  - Philosophy
EDAT- 2011/02/12 06:00
MHDA- 2011/09/10 06:00
CRDT- 2011/02/12 06:00
PHST- 2011/01/24 00:00 [received]
PHST- 2011/01/31 00:00 [accepted]
PHST- 2011/02/12 06:00 [entrez]
PHST- 2011/02/12 06:00 [pubmed]
PHST- 2011/09/10 06:00 [medline]
AID - 10.1007/s10441-011-9128-y [doi]
PST - ppublish
SO  - Acta Biotheor. 2011 Jun;59(2):153-71. doi: 10.1007/s10441-011-9128-y. Epub 2011
      Feb 11.


PMID- 21312000
OWN - NLM
STAT- MEDLINE
DCOM- 20120919
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 18
IP  - 2
DP  - 2012 Jun
TI  - Authorship and responsibility in health sciences research: a review of procedures
      for fairly allocating authorship in multi-author studies.
PG  - 199-212
LID - 10.1007/s11948-011-9263-5 [doi]
AB  - While there has been significant discussion in the health sciences and ethics
      literatures about problems associated with publication practices (e.g., ghost-
      and gift-authorship, conflicts of interest), there has been relatively little
      practical guidance developed to help researchers determine how they should fairly
      allocate credit for multi-authored publications. Fair allocation of credit
      requires that participating authors be acknowledged for their contribution and
      responsibilities, but it is not obvious what contributions should warrant
      authorship, nor who should be responsible for the quality and content of the
      scientific research findings presented in a publication. In this paper, we review
      arguments presented in the ethics and health science literatures, and the
      policies or guidelines proposed by learned societies and journals, in order to
      explore the link between author contribution and responsibility in multi-author
      multidisciplinary health science publications. We then critically examine the
      various procedures used in the field to help researchers fairly allocate
      authorship.
FAU - Smith, Elise
AU  - Smith E
AD  - Bioethics Programs, Department of Social and Preventive Medicine, School of
      Public Health, Universite de Montreal, C.P. 6128, succ. Centre-ville, Montreal,
      QC, H3C 3J7, Canada. elise.smith@umontreal.ca
FAU - Williams-Jones, Bryn
AU  - Williams-Jones B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110211
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Authorship
MH  - Biomedical Research/*ethics
MH  - *Editorial Policies
MH  - *Guidelines as Topic
MH  - Humans
MH  - Periodicals as Topic/*ethics
MH  - Publishing/*ethics
MH  - Research Personnel/ethics
MH  - *Social Responsibility
EDAT- 2011/02/12 06:00
MHDA- 2012/09/20 06:00
CRDT- 2011/02/12 06:00
PHST- 2010/09/30 00:00 [received]
PHST- 2011/01/31 00:00 [accepted]
PHST- 2011/02/12 06:00 [entrez]
PHST- 2011/02/12 06:00 [pubmed]
PHST- 2012/09/20 06:00 [medline]
AID - 10.1007/s11948-011-9263-5 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2012 Jun;18(2):199-212. doi: 10.1007/s11948-011-9263-5. Epub 2011
      Feb 11.


PMID- 21311882
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20211020
IS  - 1432-2161 (Electronic)
IS  - 0364-2348 (Linking)
VI  - 40
IP  - 10
DP  - 2011 Oct
TI  - CT-guided percutaneous cryoablation of osteoid osteoma in children: an initial
      study.
PG  - 1303-10
LID - 10.1007/s00256-011-1119-1 [doi]
AB  - OBJECTIVE: The purpose of this study was to evaluate the safety and efficacy of
      CT-guided percutaneous cryoablation for osteoid osteoma in children. MATERIALS
      AND METHODS: This study was approved by the institutional ethics committee. From 
      January 2007 to July 2008, six children (four boys, two girls, mean age 12.6
      years old) with osteoid osteoma were treated with CT-guided percutaneous
      cryoablation. The procedures were carried out under conscious sedation and local 
      anesthesia. CT guidance was used for procedural planning, instrument guidance,
      and monitoring. An argon-based cryoablation system was used. Each cryoablation
      included two freezing-thawing cycles. Follow-up was performed to assess technical
      and clinical outcome for a minimum of 12 months. A visual analog scale (VAS) was 
      used to assess severity of pain pre- and post-procedure, and mean VAS for the
      group was compared pre- and post-procedure with a t-test. The mean clinical
      follow-up period was 28.7 months (ranging from 18 to 36 months). RESULTS:
      Cryoablation was technically and clinically successful for all patients. No major
      immediate or delayed complications were observed. Significant pain relief (P
      <0.05) was observed in all patients after operation. Mean VAS were 6.57 +/- 0.55 
      pre-procedure and 0.57 +/- 0.10 1 month post-procedure. Patients were allowed to 
      fully bear their weight and function without limitation within 3 days after the
      procedure. Pain recurrence was not observed in any patient. CONCLUSION:
      Percutaneous cryoablation is safe and effective for the treatment of osteoid
      osteomas in children. Notably, this procedure can be accomplished without general
      anesthesia.
FAU - Wu, Bin
AU  - Wu B
AD  - Department of Radiology, Chinese PLA General Hospital, Fuxing Road 28, Beijing
      100853, China. mikewubin@163.com
FAU - Xiao, Yue-Yong
AU  - Xiao YY
FAU - Zhang, Xiao
AU  - Zhang X
FAU - Zhao, Lei
AU  - Zhao L
FAU - Carrino, John A
AU  - Carrino JA
LA  - eng
PT  - Journal Article
DEP - 20110212
PL  - Germany
TA  - Skeletal Radiol
JT  - Skeletal radiology
JID - 7701953
SB  - IM
MH  - Adolescent
MH  - Child
MH  - *Cryosurgery/standards
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Osteoma, Osteoid/*surgery
MH  - Patient Safety
MH  - Retrospective Studies
MH  - *Tomography, X-Ray Computed
MH  - Treatment Outcome
EDAT- 2011/02/12 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/02/12 06:00
PHST- 2010/10/18 00:00 [received]
PHST- 2011/01/25 00:00 [accepted]
PHST- 2011/01/22 00:00 [revised]
PHST- 2011/02/12 06:00 [entrez]
PHST- 2011/02/12 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - 10.1007/s00256-011-1119-1 [doi]
PST - ppublish
SO  - Skeletal Radiol. 2011 Oct;40(10):1303-10. doi: 10.1007/s00256-011-1119-1. Epub
      2011 Feb 12.


PMID- 21311694
OWN - NLM
STAT- MEDLINE
DCOM- 20110607
LR  - 20211020
IS  - 1178-2005 (Electronic)
IS  - 1176-9106 (Linking)
VI  - 6
DP  - 2011 Jan 1
TI  - Unicentric study of cell therapy in chronic obstructive pulmonary
      disease/pulmonary emphysema.
PG  - 63-71
LID - 10.2147/COPD.S15292 [doi]
AB  - Within the chronic obstructive pulmonary disease (COPD) spectrum, lung emphysema 
      presents, as a primarily histopathologic feature, the destruction of pulmonary
      parenchyma and, accordingly, an increase in the airflow obstruction distal to the
      terminal bronchiole. Notwithstanding the significant advances in prevention and
      treatment of symptoms, no effective or curative therapy has been accomplished. In
      this context, cellular therapy with stem cells (SCs) arises as a new therapeutic 
      approach, with a wide application potential. The purpose of this study is to
      evaluate the safety of SCs infusion procedure in patients with advanced COPD
      (stage IV dyspnea). After selection, patients underwent clinical examination and 
      received granulocyte colony-stimulating factor, immediately prior to the bone
      marrow harvest. The bone marrow mononuclear cells (BMMC) were isolated and
      infused into a peripheral vein. The 12-month follow-up showed a significant
      improvement in the quality of life, as well as a clinical stable condition, which
      suggest a change in the natural process of the disease. Therefore, the proposed
      methodology in this study for BMMC cell therapy in sufferers of advanced COPD was
      demonstrated to be free of significant adverse effects. Although a larger sample 
      and a greater follow-up period are needed, it is possible to infer that BMMC cell
      therapy introduces an unprecedented change in the course or in the natural
      history of emphysema, inhibiting or slowing the progression of disease. This
      clinical trial was registered with ClinicalTrials.gov (NCT01110252) and was
      approved by the Brazilian National Committee of Ethics in Research (registration 
      no. 14764, CONEP report 233/2009).
FAU - Ribeiro-Paes, Joao Tadeu
AU  - Ribeiro-Paes JT
AD  - Department of Biological Sciences, Universidade Estadual Paulista, Campus de
      Assis, Assis, SP, Brazil. jtrpaes@yahoo.com.br
FAU - Bilaqui, Aldemir
AU  - Bilaqui A
FAU - Greco, Oswaldo T
AU  - Greco OT
FAU - Ruiz, Milton Artur
AU  - Ruiz MA
FAU - Marcelino, Monica Y
AU  - Marcelino MY
FAU - Stessuk, Talita
AU  - Stessuk T
FAU - de Faria, Carolina A
AU  - de Faria CA
FAU - Lago, Mario R
AU  - Lago MR
LA  - eng
SI  - ClinicalTrials.gov/NCT01110252
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110101
PL  - New Zealand
TA  - Int J Chron Obstruct Pulmon Dis
JT  - International journal of chronic obstructive pulmonary disease
JID - 101273481
RN  - 0 (Recombinant Proteins)
RN  - 143011-72-7 (Granulocyte Colony-Stimulating Factor)
RN  - PVI5M0M1GW (Filgrastim)
SB  - IM
MH  - Aged
MH  - Brazil
MH  - Filgrastim
MH  - Forced Expiratory Volume
MH  - Granulocyte Colony-Stimulating Factor/therapeutic use
MH  - Humans
MH  - Infusions, Intravenous
MH  - Lung/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Disease, Chronic Obstructive/diagnosis/physiopathology/*surgery
MH  - Pulmonary Emphysema/diagnosis/physiopathology/*surgery
MH  - Recombinant Proteins
MH  - Severity of Illness Index
MH  - *Stem Cell Transplantation
MH  - Time Factors
MH  - Treatment Outcome
MH  - Vital Capacity
PMC - PMC3034284
OTO - NOTNLM
OT  - BMMC
OT  - cell therapy
OT  - chronic obstructive pulmonary disease COPD
OT  - pulmonary emphysema
OT  - stem cells
EDAT- 2011/02/12 06:00
MHDA- 2011/06/08 06:00
CRDT- 2011/02/12 06:00
PHST- 2011/02/12 06:00 [entrez]
PHST- 2011/02/12 06:00 [pubmed]
PHST- 2011/06/08 06:00 [medline]
AID - 10.2147/COPD.S15292 [doi]
PST - epublish
SO  - Int J Chron Obstruct Pulmon Dis. 2011 Jan 1;6:63-71. doi: 10.2147/COPD.S15292.


PMID- 21311421
OWN - NLM
STAT- MEDLINE
DCOM- 20110830
LR  - 20110211
IS  - 0026-4784 (Print)
IS  - 0026-4784 (Linking)
VI  - 63
IP  - 1
DP  - 2011 Feb
TI  - Social and ethical determinants of sexuality: gender and health.
PG  - 71-84
AB  - The aim of this paper is to expand concepts of gender and explore how behaviours 
      associated with sexual identity affect health risks, as well as the right to
      sexual expression for sexual minorities and persons with disabilities, to promote
      safe sexual behaviour and reduce the incidence of sexually transmitted diseases, 
      through the internationally sanctioned Sexual and Reproductive Health concept.
      During the XX century the multiple meanings of sexuality have been progressively 
      recognized and its physical and psychological health dimension have become a
      reality, enshrined in United Nations (UN) documents. Countries have begun to
      adapt their legislations to this new reality and Conventions today guarantee
      equal sexual and reproductive rights to persons with disabilities, while the
      nature of variant sexual behaviours is being debated. Sexual and reproductive
      health is today an acknowledged goal for every individual and the right to
      equality for persons with variant behaviours and disabilities, as well as the
      coexistence of diverse meanings of sexuality an established fact. Healthy and
      safe sexual behaviour should become an important goal for all societies and
      cultures.
FAU - Benagiano, G
AU  - Benagiano G
AD  - Department of Obstetrics and Gynecology, La Sapienza University, Rome, Italy.
      giuseppe.benagiano@uniroma1.it
FAU - Carrara, S
AU  - Carrara S
FAU - Filippi, V
AU  - Filippi V
FAU - Shedlin, M G
AU  - Shedlin MG
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - Minerva Ginecol
JT  - Minerva ginecologica
JID - 0400731
SB  - IM
MH  - Disabled Persons
MH  - Female
MH  - Humans
MH  - Interpersonal Relations
MH  - Male
MH  - Religion
MH  - Reproductive Medicine
MH  - *Sexual Behavior/ethics/psychology
MH  - Sexually Transmitted Diseases/*prevention & control
MH  - Sociology
EDAT- 2011/02/12 06:00
MHDA- 2011/08/31 06:00
CRDT- 2011/02/12 06:00
PHST- 2011/02/12 06:00 [entrez]
PHST- 2011/02/12 06:00 [pubmed]
PHST- 2011/08/31 06:00 [medline]
AID - R09113193 [pii]
PST - ppublish
SO  - Minerva Ginecol. 2011 Feb;63(1):71-84.


PMID- 21311415
OWN - NLM
STAT- MEDLINE
DCOM- 20110830
LR  - 20110211
IS  - 0026-4784 (Print)
IS  - 0026-4784 (Linking)
VI  - 63
IP  - 1
DP  - 2011 Feb
TI  - [Role of a mini-invasive approach in the diagnosis and treatment of
      tubo-peritoneal infertility as an altenative to IVF].
PG  - 1-10
AB  - AIM: Tubal factor infertility accounts for approximately 25-35% of cases of
      female infertility. Identifiable causes of tubal infertility are postinfectious
      tubal damage, postsurgical adhesion formation, and endometriosis-related
      adhesions. Aim of this study was to evaluate the results of a
      diagnostic/therapeutic minimally invasive approach in patients with suspect or
      ascertained mechanical infertility in terms of obtained pregnancies. METHODS: The
      study enrolled 143 patients who underwent diagnostic or operative laparoscopy,
      with chromopertubation, peritoneal or endometrial culture, salpingoscopy when
      indicated and diagnostic or operative hysteroscopy. Nine patients with
      submucous-intramural or multiple intramural fibroids underwent miomectomy by
      minilaparotomy following hysteroscopy and chromopertubation. Patients were
      contacted periodically by telephone to monitor the onset and outcome of
      pregnancy. The mean length of follow- up was 49 months (range: 11 to 118 months).
      RESULTS: Of the 152 patients considered in the study, 61 became pregnant (40%).
      Twenty-three pregnancies resulted in miscarriage, two in tubal pregnancy and one 
      patient aborted after a diagnosis of Down syndrome. In total, 32% of the patients
      achieved a term pregnancy. CONCLUSION: The diagnostic/therapeutic mini-invasive
      approach allows women to become pregnant naturally and it is, therefore, an
      option for couples with ethical and religious concerns. The percentage of
      pregnancies is higher than after in-vitro fertilization. When efficacious, this
      approach allows additional spontaneous conceptions without renewed therapy and
      the course of pregnancy and the type of delivery will not differ from those in a 
      normal population.
FAU - Marana, R
AU  - Marana R
AD  - Dipartimento per la Tutela della Salute della Donna e della Vita Nascente,
      Policlinico Universitario Agostino Gemelli, Roma, Italia.
      riccardo.marana@rm.unicatt.it
FAU - Ferrari, S
AU  - Ferrari S
FAU - Merola, A
AU  - Merola A
FAU - Astorri, A L
AU  - Astorri AL
FAU - Pompa, G
AU  - Pompa G
FAU - Milardi, D
AU  - Milardi D
FAU - Giampietro, A
AU  - Giampietro A
FAU - Lecca, A
AU  - Lecca A
FAU - Marana, E
AU  - Marana E
LA  - ita
PT  - English Abstract
PT  - Journal Article
TT  - Il ruolo di un approccio chirurgico mini-invasivo nello diagnosi e trattamento
      della sterilita tubo-peritoneale in alternativa alla FIVET.
PL  - Italy
TA  - Minerva Ginecol
JT  - Minerva ginecologica
JID - 0400731
SB  - IM
MH  - Adult
MH  - Endometriosis/complications/diagnosis/surgery
MH  - Fallopian Tube Diseases/complications/*diagnosis/surgery
MH  - Female
MH  - Humans
MH  - Infertility, Female/*diagnosis/etiology/*surgery
MH  - *Laparoscopy
MH  - Middle Aged
MH  - Peritoneum
EDAT- 2011/02/12 06:00
MHDA- 2011/08/31 06:00
CRDT- 2011/02/12 06:00
PHST- 2011/02/12 06:00 [entrez]
PHST- 2011/02/12 06:00 [pubmed]
PHST- 2011/08/31 06:00 [medline]
AID - R09113202 [pii]
PST - ppublish
SO  - Minerva Ginecol. 2011 Feb;63(1):1-10.


PMID- 21311340
OWN - NLM
STAT- MEDLINE
DCOM- 20110615
LR  - 20220210
IS  - 1530-0366 (Electronic)
IS  - 1098-3600 (Linking)
VI  - 13
IP  - 3
DP  - 2011 Mar
TI  - Downsizing genomic medicine: approaching the ethical complexity of whole-genome
      sequencing by starting small.
PG  - 191-4
LID - 10.1097/GIM.0b013e31820f603f [doi]
AB  - As we look to a time when whole-genome sequencing is integrated into patient
      care, it is possible to anticipate a number of ethical challenges that will need 
      to be addressed. The most intractable of these concern informed consent and the
      responsible management of very large amounts of genetic information. Given the
      range of possible findings, it remains unclear to what extent it will be possible
      to obtain meaningful patient consent to genomic testing. Equally unclear is how
      clinicians will disseminate the enormous volume of genetic information produced
      by whole-genome sequencing. Toward developing practical strategies for managing
      these ethical challenges, we propose a research agenda that approaches
      multiplexed forms of clinical genetic testing as natural laboratories in which to
      develop best practices for managing the ethical complexities of genomic medicine.
FAU - Sharp, Richard R
AU  - Sharp RR
AD  - Department of Bioethics and Genomic Medicine Institute, Lerner College of
      Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA. sharpr3@ccf.org
LA  - eng
GR  - HG003390/HG/NHGRI NIH HHS/United States
GR  - HG004500/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Genet Med
JT  - Genetics in medicine : official journal of the American College of Medical
      Genetics
JID - 9815831
SB  - IM
MH  - Confidentiality
MH  - Genetic Testing/ethics
MH  - Genetics, Medical/*ethics/*standards
MH  - Genome, Human/genetics
MH  - Humans
MH  - Informed Consent
MH  - Sequence Analysis/ethics
EDAT- 2011/02/12 06:00
MHDA- 2011/06/16 06:00
CRDT- 2011/02/12 06:00
PHST- 2011/02/12 06:00 [entrez]
PHST- 2011/02/12 06:00 [pubmed]
PHST- 2011/06/16 06:00 [medline]
AID - 10.1097/GIM.0b013e31820f603f [doi]
AID - S1098-3600(21)00133-7 [pii]
PST - ppublish
SO  - Genet Med. 2011 Mar;13(3):191-4. doi: 10.1097/GIM.0b013e31820f603f.


PMID- 21311265
OWN - NLM
STAT- MEDLINE
DCOM- 20110616
LR  - 20110211
IS  - 1550-5073 (Electronic)
IS  - 0893-2190 (Linking)
VI  - 25
IP  - 1
DP  - 2011 Jan-Mar
TI  - Truth telling and severe fetal diagnosis: a virtue ethics perspective.
PG  - 13-20
LID - 10.1097/JPN.0b013e318201edff [doi]
AB  - PURPOSE: Increased use of prenatal technologies has increased the numbers of
      women and partners whose fetus is diagnosed with a severe impairment. Virtue
      ethics provides a useful perspective to consider truth telling in this context,
      specifically how couples and providers interpret the diagnosis and prognosis to
      create truth. Virtue ethics is person-centered rather than act-centered, with
      moral actions guided by how a virtuous person would act in the same circumstance.
      Phronesis (practical wisdom) guides these actions. SUBJECTS AND METHODS: Fifteen 
      women and 10 male partners with a severe fetal diagnosis participated in this
      longitudinal ethnography examining their experiences across 3 available care
      options: termination, routine obstetric care, and perinatal end-of-life care.
      Data from 39 interviews were analyzed to determine how they created meaning and
      truth in context of the diagnosis. RESULTS AND CONCLUSIONS: Providers'
      interactions were usually, but not always, characterized by the practice of
      phronesis. Couples were in a more complex moral situation than were providers.
      Those who terminated created a socially acceptable truth within a negative social
      environment related to abortion. Those seeking routine care had uncertain fetal
      prognoses and struggled with the meanings of "odds" of survival. One couple with 
      end-of-life care experienced a close alignment of the facts and the truth they
      made public.
FAU - Black, Beth Perry
AU  - Black BP
AD  - School of Nursing, University of North Carolina at Chapel Hill, Chapel Hill, NC
      27599, USA. beth_black@unc.edu
LA  - eng
GR  - K12 HD01441/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Perinat Neonatal Nurs
JT  - The Journal of perinatal & neonatal nursing
JID - 8801387
MH  - Abnormalities, Multiple/*nursing/*psychology
MH  - Adaptation, Psychological
MH  - Adult
MH  - Ethics, Nursing
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Neonatal Nursing/*ethics
MH  - Nurse-Patient Relations/*ethics
MH  - Parents/*psychology
MH  - Philosophy, Nursing
MH  - Pregnancy
MH  - Truth Disclosure/*ethics
MH  - Young Adult
EDAT- 2011/02/12 06:00
MHDA- 2011/06/17 06:00
CRDT- 2011/02/12 06:00
PHST- 2011/02/12 06:00 [entrez]
PHST- 2011/02/12 06:00 [pubmed]
PHST- 2011/06/17 06:00 [medline]
AID - 10.1097/JPN.0b013e318201edff [doi]
AID - 00005237-201101000-00008 [pii]
PST - ppublish
SO  - J Perinat Neonatal Nurs. 2011 Jan-Mar;25(1):13-20. doi:
      10.1097/JPN.0b013e318201edff.


PMID- 21311241
OWN - NLM
STAT- MEDLINE
DCOM- 20110830
LR  - 20200930
IS  - 1551-4005 (Electronic)
IS  - 1551-4005 (Linking)
VI  - 10
IP  - 4
DP  - 2011 Feb 15
TI  - Daring to venture beyond the bench.
PG  - 553-60
AB  - Few people are exactly where they thought they would be 20 years into their
      careers. Careers, like life, are full of twists and turns. Brains and an
      inviolable work ethic are table stakes in virtually every profession involving
      science. Beyond these basics, however, each of us brings our personal blend of
      talents and skills to creating a career. Some of us know exactly what we want and
      chart a direct course. Others are masters at seizing opportunities. Still others 
      go with the natural flow of events. Since success and security can only come with
      time, begin by choosing your adventure. Follow your interests and passions.
      Radically rewrite your resume, network, take people to coffee, get out of your
      comfort zone. Sticking to the same things you've already tried simply means you
      travel the same path over and over. Stepping out into the unknown can be scary,
      but it can also lead to unexpected places. Take a look.
FAU - Wylie, Catarina
AU  - Wylie C
AD  - Landes Bioscience, Austin, TX USA.
LA  - eng
PT  - Interview
DEP - 20110215
PL  - United States
TA  - Cell Cycle
JT  - Cell cycle (Georgetown, Tex.)
JID - 101137841
SB  - IM
MH  - Biotechnology
MH  - *Career Choice
MH  - *Career Mobility
MH  - Cell Biology
MH  - Computational Biology
MH  - Intellectual Property
MH  - Molecular Biology
MH  - Publishing
EDAT- 2011/02/12 06:00
MHDA- 2011/08/31 06:00
CRDT- 2011/02/12 06:00
PHST- 2011/02/12 06:00 [entrez]
PHST- 2011/02/12 06:00 [pubmed]
PHST- 2011/08/31 06:00 [medline]
AID - 14922 [pii]
AID - 10.4161/cc.10.4.14922 [doi]
PST - ppublish
SO  - Cell Cycle. 2011 Feb 15;10(4):553-60. doi: 10.4161/cc.10.4.14922. Epub 2011 Feb
      15.


PMID- 21311013
OWN - NLM
STAT- MEDLINE
DCOM- 20110302
LR  - 20110610
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Linking)
VI  - 331
IP  - 6018
DP  - 2011 Feb 11
TI  - Ensuring the data-rich future of the social sciences.
PG  - 719-21
LID - 10.1126/science.1197872 [doi]
AB  - Massive increases in the availability of informative social science data are
      making dramatic progress possible in analyzing, understanding, and addressing
      many major societal problems. Yet the same forces pose severe challenges to the
      scientific infrastructure supporting data sharing, data management, informatics, 
      statistical methodology, and research ethics and policy, and these are
      collectively holding back progress. I address these changes and challenges and
      suggest what can be done.
FAU - King, Gary
AU  - King G
AD  - Institute for Quantitative Social Science, 1737 Cambridge Street, Harvard
      University, Cambridge, MA 02138, USA. king@harvard.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
SB  - IM
CIN - Science. 2011 Jun 10;332(6035):1263. PMID: 21659589
MH  - Access to Information
MH  - Humans
MH  - *Informatics
MH  - *Information Dissemination
MH  - *Information Management
MH  - Information Storage and Retrieval
MH  - Privacy
MH  - Publishing
MH  - *Social Sciences/ethics/trends
EDAT- 2011/02/12 06:00
MHDA- 2011/03/03 06:00
CRDT- 2011/02/12 06:00
PHST- 2011/02/12 06:00 [entrez]
PHST- 2011/02/12 06:00 [pubmed]
PHST- 2011/03/03 06:00 [medline]
AID - 331/6018/719 [pii]
AID - 10.1126/science.1197872 [doi]
PST - ppublish
SO  - Science. 2011 Feb 11;331(6018):719-21. doi: 10.1126/science.1197872.


PMID- 21310675
OWN - NLM
STAT- MEDLINE
DCOM- 20120524
LR  - 20191210
IS  - 1872-9177 (Electronic)
IS  - 1769-7255 (Linking)
VI  - 7
IP  - 7
DP  - 2011 Dec
TI  - [Outcome and outlook of living donor kidney transplantation activity in France].
PG  - 535-43
LID - 10.1016/j.nephro.2011.01.001 [doi]
AB  - INTRODUCTION: In France, the bioethic law of 2004 authorized the extension of the
      living donor (LD) pool to members of the extended family and any person
      justifying of a 2 year-long relationship. The number of living donor kidney
      transplantation (LDKT) increased until reaching a maximum of 246 grafts in 2006
      (9% of total activity). Two years later, in 2008, LKG activity slowed down to
      7.6% of the total activity (222 grafts). METHODS: We analyzed all LDKT carried
      out in France since 2000 according to various indicators. In addition, a
      questionnaire was sent to renal transplant teams in order to identify potential
      causes for the decrease in LKG observed in France. RESULTS: From 2000 to 2006,
      over 1400 LDKT were performed in France. However, donor to recipient relations
      show that the large increase observed in 2006 was not linked to the extension of 
      the LD pool. LDKT activity then started decreasing as soon as 2007. The
      questionnaire was sent back by 40/44 (91%) renal transplant teams. Their answers 
      led to the identification of potential constrain impacting LDKT activity in
      France. Among these obstacles: workload and time-consuming to prepare the
      transplantation and the donor, ethical constrains and lack of appropriate
      communication and information delivered to the professionals. DISCUSSION: The
      important increase in LKG activity in 2006 is not clearly understood. However,
      several approaches to develop the activity in the next years have been
      identified.
CI  - Copyright (c) 2011 Association Societe de nephrologie. Published by Elsevier SAS.
      All rights reserved.
FAU - Lamy, Francois-Xavier
AU  - Lamy FX
AD  - Agence de la biomedecine, direction medicale et scientifique-1, avenue du
      Stade-de-France-Saint-Denis, 93212 La-Plaine cedex, France.
      francoisxavier.lamy@biomedecine.fr
FAU - Savoye, Emilie
AU  - Savoye E
FAU - Macher, Marie-Alice
AU  - Macher MA
FAU - Thuong, Marie
AU  - Thuong M
LA  - fre
PT  - Journal Article
TT  - Bilan et perspectives de l'activite de greffe renale a partir de donneur vivant
      en France.
DEP - 20110209
PL  - France
TA  - Nephrol Ther
JT  - Nephrologie & therapeutique
JID - 101248950
SB  - IM
CIN - Nephrol Ther. 2011 Dec;7(7):519-20. PMID: 21600863
MH  - Communication
MH  - Ethics
MH  - Family
MH  - France/epidemiology
MH  - Health Care Surveys
MH  - Humans
MH  - Kidney Failure, Chronic/*surgery
MH  - Kidney Transplantation/legislation & jurisprudence/*statistics & numerical
      data/*trends
MH  - Living Donors/legislation & jurisprudence/*statistics & numerical data
MH  - Outcome Assessment, Health Care
MH  - *Patient Care Team
MH  - Risk Factors
MH  - Surveys and Questionnaires
MH  - Time Factors
MH  - Workload
EDAT- 2011/02/12 06:00
MHDA- 2012/05/25 06:00
CRDT- 2011/02/12 06:00
PHST- 2010/03/09 00:00 [received]
PHST- 2010/11/26 00:00 [revised]
PHST- 2011/01/02 00:00 [accepted]
PHST- 2011/02/12 06:00 [entrez]
PHST- 2011/02/12 06:00 [pubmed]
PHST- 2012/05/25 06:00 [medline]
AID - S1769-7255(11)00003-4 [pii]
AID - 10.1016/j.nephro.2011.01.001 [doi]
PST - ppublish
SO  - Nephrol Ther. 2011 Dec;7(7):535-43. doi: 10.1016/j.nephro.2011.01.001. Epub 2011 
      Feb 9.


PMID- 21310404
OWN - NLM
STAT- MEDLINE
DCOM- 20110621
LR  - 20110420
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 95
IP  - 6
DP  - 2011 May
TI  - Quintuplets after a transfer of two embryos following in vitro fertilization: a
      proved superfecundation.
PG  - 2124.e13-6
LID - 10.1016/j.fertnstert.2011.01.029 [doi]
AB  - OBJECTIVE: To report a genetically proved superfecundation of quintuplets after
      transfer of two embryos in IVF procedure and successful completion of the
      pregnancy after fetal reduction. DESIGN: Case report. SETTING: Academic
      reproductive medicine center. PATIENT(S): A 31-year-old woman, gravida 0, who
      underwent her second IVF cycle after three IUIs. INTERVENTION(S): After 5 years
      of primary infertility, three IUIs, and one IVF, the patient underwent her second
      IVF cycle with transfer of two fresh embryos on day 2. MAIN OUTCOME MEASURE(S):
      Development of five separate embryonic sacs. Fetal reduction to twins at 12 weeks
      of gestation. Successful pregnancy and delivery. Deoxyribonucleic acid analysis
      of the three reduced embryos, the live-born twins, and their parents. RESULT(S): 
      Analysis of the seven DNA samples, because all were different, confirmed the
      superfecundation and disproved the zygote's division after transfer. Fetal growth
      restriction motivated preterm delivery by cesarean section. Both twins were in
      good health. CONCLUSION(S): Superfecundation can explain high-order multiple
      pregnancy and can be proved by DNA analysis. Couples must be informed because of 
      the implications of fetal reduction for ethical issues, risks of pregnancy loss, 
      fetal growth restriction, preterm delivery, and its consequences.
CI  - Copyright (c) 2011 American Society for Reproductive Medicine. Published by
      Elsevier Inc. All rights reserved.
FAU - Peigne, Maeliss
AU  - Peigne M
AD  - Service de Gynecologie endocrinienne et Medecine de la Reproduction, CHRU Lille, 
      France. maeliss_peigne@hotmail.com
FAU - Andrieux, Joris
AU  - Andrieux J
FAU - Deruelle, Philippe
AU  - Deruelle P
FAU - Vuillaume, Isabelle
AU  - Vuillaume I
FAU - Leroy, Maryse
AU  - Leroy M
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20110209
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
SB  - IM
MH  - Adult
MH  - Embryo Transfer/*methods
MH  - Female
MH  - Fertility/*physiology
MH  - *Fertilization in Vitro/methods
MH  - Humans
MH  - Infant, Newborn
MH  - Pregnancy
MH  - Pregnancy Reduction, Multifetal
MH  - *Pregnancy, Multiple/physiology
MH  - *Quintuplets
MH  - Twins
EDAT- 2011/02/12 06:00
MHDA- 2011/06/22 06:00
CRDT- 2011/02/12 06:00
PHST- 2010/10/22 00:00 [received]
PHST- 2010/12/29 00:00 [revised]
PHST- 2011/01/07 00:00 [accepted]
PHST- 2011/02/12 06:00 [entrez]
PHST- 2011/02/12 06:00 [pubmed]
PHST- 2011/06/22 06:00 [medline]
AID - S0015-0282(11)00039-2 [pii]
AID - 10.1016/j.fertnstert.2011.01.029 [doi]
PST - ppublish
SO  - Fertil Steril. 2011 May;95(6):2124.e13-6. doi: 10.1016/j.fertnstert.2011.01.029. 
      Epub 2011 Feb 9.


PMID- 21310174
OWN - NLM
STAT- MEDLINE
DCOM- 20110815
LR  - 20110502
IS  - 1095-6808 (Electronic)
IS  - 0091-3022 (Linking)
VI  - 32
IP  - 2
DP  - 2011 Apr
TI  - Developmental, sexual and reproductive neuroendocrinology: historical, clinical
      and ethical considerations.
PG  - 255-63
LID - 10.1016/j.yfrne.2011.02.003 [doi]
AB  - Different milestones have marked the development of the field of
      neuroendocrinology. This is an essay in which a new direction is proposed; one in
      which the field is marked more by a concern for ethical considerations than
      experimental procedures. Among the primary concerns is the need for a national
      registry for intersex and transsexual cases to follow how they are managed and to
      assess the long-term results. As in Europe, the data in the registries should be 
      available to qualified and certified researchers and clinicians for analysis. A
      secondary focus is on the surgery often imposed in cases of intersex. Many
      current procedures have been found to have negative effects. The overall aim is
      to provide better management and treatment. Other topics are offered for ethical 
      consideration.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Diamond, Milton
AU  - Diamond M
LA  - eng
PT  - Editorial
DEP - 20110218
PL  - United States
TA  - Front Neuroendocrinol
JT  - Frontiers in neuroendocrinology
JID - 7513292
RN  - 0 (Androgens)
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Androgens/physiology
MH  - Disorders of Sex Development/genetics/therapy
MH  - Environmental Pollutants/adverse effects
MH  - Female
MH  - Humans
MH  - Informed Consent/ethics
MH  - Male
MH  - Neuroendocrinology/*ethics
MH  - Penis/abnormalities/surgery
MH  - Registries/*ethics
MH  - Sexual Behavior/ethics/physiology
MH  - Sexual Development/*physiology
MH  - Transsexualism/therapy
EDAT- 2011/02/12 06:00
MHDA- 2011/08/16 06:00
CRDT- 2011/02/12 06:00
PHST- 2011/02/12 06:00 [entrez]
PHST- 2011/02/12 06:00 [pubmed]
PHST- 2011/08/16 06:00 [medline]
AID - S0091-3022(11)00021-5 [pii]
AID - 10.1016/j.yfrne.2011.02.003 [doi]
PST - ppublish
SO  - Front Neuroendocrinol. 2011 Apr;32(2):255-63. doi: 10.1016/j.yfrne.2011.02.003.
      Epub 2011 Feb 18.


PMID- 21310040
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20211020
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 12
DP  - 2011 Feb 10
TI  - A method to study the effect of bronchodilators on smoke retention in COPD
      patients: study protocol for a randomized controlled trial.
PG  - 37
LID - 10.1186/1745-6215-12-37 [doi]
AB  - BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a common disease,
      associated with cardiovascular disease. Many patients use (long-acting)
      bronchodilators, whilst they continue smoking alongside. We hypothesised an
      interaction between bronchodilators and smoking that enhances smoke exposure, and
      hence cardiovascular disease. In this paper, we report our study protocol that
      explores the fundamental interaction, i.e. smoke retention. METHOD: The design
      consists of a double-blinded, placebo-controlled, randomised crossover trial, in 
      which 40 COPD patients smoke cigarettes during both undilated and maximal
      bronchodilated conditions. Our primary outcome is the retention of cigarette
      smoke, expressed as tar and nicotine weight. The inhaled tar weights are
      calculated from the correlated extracted nicotine weights in cigarette filters,
      whereas the exhaled weights are collected on Cambridge filters. We established
      the inhaled weight calculations by a pilot study, that included paired
      measurements from several smoking regimes. Our study protocol is approved by the 
      local accredited medical review ethics committee. DISCUSSION: Our study is
      currently in progress. The pilot study revealed valid equations for inhaled tar
      and nicotine, with an R2 of 0.82 and 0.74 (p < 0.01), respectively. We developed 
      a method to study pulmonary smoke retentions in COPD patients under the influence
      of bronchodilation which may affect smoking-related disease. This trial will
      provide fundamental knowledge about the (cardiovascular) safety of
      bronchodilators in patients with COPD who persist in their habit of cigarette
      smoking. TRIAL REGISTRATION: ClinicalTrials.gov: NCT00981851.
FAU - van Dijk, W D
AU  - van Dijk WD
AD  - Department of Primary and Community Care, Radboud University Nijmegen Medical
      Centre, Nijmegen, the Netherlands. w.vandijk@aios.umcn.nl
FAU - Scheepers, P T J
AU  - Scheepers PT
FAU - Cremers, R
AU  - Cremers R
FAU - Lenders, J W M
AU  - Lenders JW
FAU - Klerx, W
AU  - Klerx W
FAU - van Weel, C
AU  - van Weel C
FAU - Schermer, T R J
AU  - Schermer TR
FAU - Heijdra, Y
AU  - Heijdra Y
LA  - eng
SI  - ClinicalTrials.gov/NCT00981851
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110210
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
RN  - 0 (Bronchodilator Agents)
SB  - IM
MH  - Administration, Inhalation
MH  - Breath Tests
MH  - Bronchodilator Agents/*administration & dosage/adverse effects
MH  - Cardiovascular Diseases/*etiology
MH  - Cross-Over Studies
MH  - Double-Blind Method
MH  - Humans
MH  - Inhalation Exposure
MH  - Lung/*drug effects/physiopathology
MH  - Netherlands
MH  - Pulmonary Disease, Chronic Obstructive/*drug therapy/etiology/physiopathology
MH  - *Research Design
MH  - Respiratory Function Tests
MH  - Risk Assessment
MH  - Risk Factors
MH  - Smoking/*adverse effects
MH  - Surveys and Questionnaires
PMC - PMC3048554
EDAT- 2011/02/12 06:00
MHDA- 2011/06/29 06:00
CRDT- 2011/02/12 06:00
PHST- 2010/07/02 00:00 [received]
PHST- 2011/02/10 00:00 [accepted]
PHST- 2011/02/12 06:00 [entrez]
PHST- 2011/02/12 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
AID - 1745-6215-12-37 [pii]
AID - 10.1186/1745-6215-12-37 [doi]
PST - epublish
SO  - Trials. 2011 Feb 10;12:37. doi: 10.1186/1745-6215-12-37.


PMID- 21310021
OWN - NLM
STAT- MEDLINE
DCOM- 20130423
LR  - 20220311
IS  - 1748-5908 (Electronic)
IS  - 1748-5908 (Linking)
VI  - 6
DP  - 2011 Feb 10
TI  - Implementing accountability for reasonableness framework at district level in
      Tanzania: a realist evaluation.
PG  - 11
LID - 10.1186/1748-5908-6-11 [doi]
AB  - BACKGROUND: Despite the growing importance of the Accountability for
      Reasonableness (A4R) framework in priority setting worldwide, there is still an
      inadequate understanding of the processes and mechanisms underlying its influence
      on legitimacy and fairness, as conceived and reflected in service management
      processes and outcomes. As a result, the ability to draw scientifically sound
      lessons for the application of the framework to services and interventions is
      limited. This paper evaluates the experiences of implementing the A4R approach in
      Mbarali District, Tanzania, in order to find out how the innovation was shaped,
      enabled, and constrained by the interaction between contexts, mechanisms and
      outcomes. METHODS: This study draws on the principles of realist evaluation -- a 
      largely qualitative approach, chiefly concerned with testing and refining
      programme theories by exploring the complex interactions of contexts, mechanisms,
      and outcomes. Mixed methods were used in data collection, including individual
      interviews, non-participant observation, and document reviews. A thematic
      framework approach was adopted for the data analysis. RESULTS: The study found
      that while the A4R approach to priority setting was helpful in strengthening
      transparency, accountability, stakeholder engagement, and fairness, the efforts
      at integrating it into the current district health system were challenging.
      Participatory structures under the decentralisation framework, central
      government's call for partnership in district-level planning and priority
      setting, perceived needs of stakeholders, as well as active engagement between
      researchers and decision makers all facilitated the adoption and implementation
      of the innovation. In contrast, however, limited local autonomy, low level of
      public awareness, unreliable and untimely funding, inadequate accountability
      mechanisms, and limited local resources were the major contextual factors that
      hampered the full implementation. CONCLUSION: This study documents an important
      first step in the effort to introduce the ethical framework A4R into district
      planning processes. This study supports the idea that a greater involvement and
      accountability among local actors through the A4R process may increase the
      legitimacy and fairness of priority-setting decisions. Support from researchers
      in providing a broader and more detailed analysis of health system elements, and 
      the socio-cultural context, could lead to better prediction of the effects of the
      innovation and pinpoint stakeholders' concerns, thereby illuminating areas that
      require special attention to promote sustainability.
FAU - Maluka, Stephen
AU  - Maluka S
AD  - Institute of Development Studies, University of Dar Es Salaam, P.O. Box 35169 Dar
      Es Salaam, Tanzania. stephenmaluka@yahoo.co.uk
FAU - Kamuzora, Peter
AU  - Kamuzora P
FAU - Sansebastian, Miguel
AU  - Sansebastian M
FAU - Byskov, Jens
AU  - Byskov J
FAU - Ndawi, Benedict
AU  - Ndawi B
FAU - Olsen, Oystein E
AU  - Olsen OE
FAU - Hurtig, Anna-Karin
AU  - Hurtig AK
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110210
PL  - England
TA  - Implement Sci
JT  - Implementation science : IS
JID - 101258411
SB  - IM
MH  - Health Priorities/organization & administration/*standards
MH  - Health Resources/organization & administration/standards
MH  - Humans
MH  - Outcome and Process Assessment, Health Care/methods/*standards
MH  - Program Development
MH  - Regional Health Planning/methods/standards
MH  - *Social Responsibility
MH  - Tanzania
PMC - PMC3041695
GN  - NLM: Original DateCompleted: 20110714
EDAT- 2011/02/12 06:00
MHDA- 2011/02/12 06:01
CRDT- 2011/02/12 06:00
PHST- 2010/07/30 00:00 [received]
PHST- 2011/02/10 00:00 [accepted]
PHST- 2011/02/12 06:00 [entrez]
PHST- 2011/02/12 06:00 [pubmed]
PHST- 2011/02/12 06:01 [medline]
AID - 1748-5908-6-11 [pii]
AID - 10.1186/1748-5908-6-11 [doi]
PST - epublish
SO  - Implement Sci. 2011 Feb 10;6:11. doi: 10.1186/1748-5908-6-11.


PMID- 21309878
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20110608
IS  - 1440-1754 (Electronic)
IS  - 1034-4810 (Linking)
VI  - 47
IP  - 6
DP  - 2011 Jun
TI  - The placebo mystique: Implications for clinical trial methodology.
PG  - 361-6
LID - 10.1111/j.1440-1754.2010.01983.x [doi]
AB  - AIM: The World Medical Association Declaration of Helsinki states that the use of
      a placebo in a clinical trial can only be justified ethically when no proven
      active treatment is available as a comparison. Despite this, placebos remain a
      popular choice as controls in clinical trials. Recent literature reviews have
      suggested that reliance on placebos may, in part, be because of methodological
      misconceptions about the need for placebos to control for the 'placebo effect'.
      This study aimed to assess doctors' understanding of the requirements for placebo
      use in clinical trials. METHODS: Two hundred doctors working in tertiary
      hospitals in Melbourne, Australia were surveyed in regards to their understanding
      of the role of the placebo and placebo effects in clinical trials. There was a
      72% response rate. Doctors were specifically asked if a placebo was required in a
      randomised clinical trial, in preference to another form of control, to control
      for the 'placebo effect'. RESULTS: The majority of respondents (62%) incorrectly 
      believed that placebos are essential to control for the 'placebo effect' in a
      randomised clinical trial. CONCLUSIONS: Misconceptions about the methodological
      requirement for placebos in randomised controlled trials may influence researcher
      decisions to use placebo controls in unethical situations.
CI  - (c) 2011 The Author. Journal of Paediatrics and Child Health (c) 2011 Paediatrics
      and Child Health Division (Royal Australasian College of Physicians).
FAU - Clifford, Vanessa
AU  - Clifford V
AD  - Murdoch Children's Research Institute, Parkville, Victoria, Australia.
      vanessa.clifford@rch.org.au
LA  - eng
PT  - Journal Article
DEP - 20110211
PL  - Australia
TA  - J Paediatr Child Health
JT  - Journal of paediatrics and child health
JID - 9005421
RN  - 0 (Placebos)
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Health Care Surveys
MH  - Humans
MH  - Medical Staff, Hospital/*psychology
MH  - *Placebos
MH  - Randomized Controlled Trials as Topic/*ethics
MH  - Victoria
EDAT- 2011/02/12 06:00
MHDA- 2011/11/09 06:00
CRDT- 2011/02/12 06:00
PHST- 2011/02/12 06:00 [entrez]
PHST- 2011/02/12 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - 10.1111/j.1440-1754.2010.01983.x [doi]
PST - ppublish
SO  - J Paediatr Child Health. 2011 Jun;47(6):361-6. doi:
      10.1111/j.1440-1754.2010.01983.x. Epub 2011 Feb 11.


PMID- 21309078
OWN - NLM
STAT- MEDLINE
DCOM- 20111012
LR  - 20191210
IS  - 1551-3793 (Electronic)
IS  - 1551-3777 (Linking)
VI  - 7
IP  - 3
DP  - 2011 Jul
TI  - Toward sustainability: a case study demonstrating transdisciplinary learning
      through the selection and use of indicators in a decision-making process.
PG  - 483-98
LID - 10.1002/ieam.181 [doi]
AB  - The purpose of this article is to use a case study example to demonstrate how a
      transparent, transdisciplinary approach to decision making allows the US
      Environmental Protection Agency Region III (USEPA Region III) to fulfill its
      decision-making responsibilities while taking critical steps toward engaging in
      sustainability discussions. The case study goals were to use information about
      environmental condition to inform staff and fiscal resource prioritization and
      allocation for the federal 2010 fiscal year. This article will use a select group
      of 3 indicators to show 1) that data are not the same as indicators, 2) the
      feasibility of using disparate data in the same analysis, and 3) specific
      discussions about indicators can lead to transdisciplinary learning, supporting
      more informed decision making. We show that, when used in a transdisciplinary
      learning process, these indicator lessons provide a stepping stone for
      organizations like USEPA Region III to consider sustainability as more than just 
      a lofty, ethical concept. Instead, these kinds of organizations can more
      routinely and substantively address sustainability through a progression of
      individual decisions. We discuss how sustainability can be linked to decision
      making through a process that requires stakeholders to articulate and confront
      their values. In this process, selecting indicators and understanding what those 
      choices imply regarding the issues that are highlighted and the population
      affected is part of the assessment of environmental condition, which is the focus
      of the case study.
CI  - Copyright (c) 2011 SETAC.
FAU - Stahl, Cynthia
AU  - Stahl C
AD  - US Environmental Protection Agency, Region III (3EA10), 1650 Arch Street,
      Philadelphia, Pennsylvania 19103, USA. stahl.cynthia@epa.gov
FAU - Cimorelli, Alan
AU  - Cimorelli A
FAU - Mazzarella, Christine
AU  - Mazzarella C
FAU - Jenkins, Bill
AU  - Jenkins B
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Integr Environ Assess Manag
JT  - Integrated environmental assessment and management
JID - 101234521
SB  - IM
MH  - Abstracting and Indexing
MH  - Animals
MH  - Atlantic Ocean
MH  - *Decision Making
MH  - Environment
MH  - Humans
MH  - *Learning
MH  - Program Evaluation/*standards
MH  - Quality Control
MH  - United States
MH  - United States Environmental Protection Agency/legislation & jurisprudence
EDAT- 2011/02/11 06:00
MHDA- 2011/10/13 06:00
CRDT- 2011/02/11 06:00
PHST- 2011/02/11 06:00 [entrez]
PHST- 2011/02/11 06:00 [pubmed]
PHST- 2011/10/13 06:00 [medline]
AID - 10.1002/ieam.181 [doi]
PST - ppublish
SO  - Integr Environ Assess Manag. 2011 Jul;7(3):483-98. doi: 10.1002/ieam.181.


PMID- 21309035
OWN - NLM
STAT- MEDLINE
DCOM- 20111012
LR  - 20110426
IS  - 1098-1004 (Electronic)
IS  - 1059-7794 (Linking)
VI  - 32
IP  - 5
DP  - 2011 May
TI  - A SImplified method for Segregation Analysis (SISA) to determine penetrance and
      expression of a genetic variant in a family.
PG  - 568-71
LID - 10.1002/humu.21441 [doi]
AB  - A method for SImplified rapid Segregation Analysis (SISA) to assess penetrance
      and expression of genetic variants in pedigrees of any complexity is presented.
      For this purpose the probability for recombination between the variant and the
      gene is zero. An assumption is that the variant of undetermined significance
      (VUS) is introduced into the family once only. If so, all family members in
      between two members demonstrated to carry a VUS, are obligate carriers.
      Probabilities for cosegregation of disease and VUS by chance, penetrance, and
      expression, may be calculated. SISA return values do not include person
      identifiers and need no explicit informed consent. There will be no ethical
      complications in submitting SISA return values to central databases. Values for
      several families may be combined. Values for a family may be updated by the
      contributor. SISA is used to consider penetrance whenever sequencing demonstrates
      a VUS in the known cancer-predisposing genes. Any family structure at hand in a
      genetic clinic may be used. One may include an extended lineage in a family
      through demonstrating the same VUS in a distant relative, and thereby identifying
      all obligate carriers in between. Such extension is a way to escape the selection
      biases through expanding the families outside the clusters used to select the
      families.
CI  - (c) 2011 Wiley-Liss, Inc.
FAU - Moller, Pal
AU  - Moller P
AD  - Section for Cancer Genetics, Department of Genetics, Radiumhosptialet, Oslo
      University Hospital, N-0310 Oslo, Norway. Moller.pal@gmail.com
FAU - Clark, Neal
AU  - Clark N
FAU - Maehle, Lovise
AU  - Maehle L
LA  - eng
PT  - Journal Article
DEP - 20110222
PL  - United States
TA  - Hum Mutat
JT  - Human mutation
JID - 9215429
SB  - IM
MH  - Computational Biology/methods
MH  - Family
MH  - *Genetic Predisposition to Disease
MH  - *Genetic Variation
MH  - Humans
MH  - Methods
MH  - *Models, Theoretical
MH  - *Penetrance
EDAT- 2011/02/11 06:00
MHDA- 2011/10/13 06:00
CRDT- 2011/02/11 06:00
PHST- 2010/09/11 00:00 [received]
PHST- 2010/12/14 00:00 [accepted]
PHST- 2011/02/11 06:00 [entrez]
PHST- 2011/02/11 06:00 [pubmed]
PHST- 2011/10/13 06:00 [medline]
AID - 10.1002/humu.21441 [doi]
PST - ppublish
SO  - Hum Mutat. 2011 May;32(5):568-71. doi: 10.1002/humu.21441. Epub 2011 Feb 22.


PMID- 21308413
OWN - NLM
STAT- MEDLINE
DCOM- 20110711
LR  - 20211020
IS  - 1573-6547 (Electronic)
IS  - 0278-095X (Linking)
VI  - 32
IP  - 1
DP  - 2011 Feb
TI  - Should people with unhealthy lifestyles pay higher health insurance premiums?
PG  - 17-21
LID - 10.1007/s10935-011-0235-y [doi]
AB  - This commentary sets the article by Dubois on the ethical justification for
      charging higher insurance premiums for people with unhealthy lifestyles in the
      context of US health care reform. It reviews the relevance and strength of
      normative concerns identified by Dubois about the acceptability of such
      differentiated "means-tested" plans. It identifies key issues involving whether
      certain health behaviors matter ethically, and if so, the grounds that would
      justify an obligation for people to take action. The article frames the answer in
      terms of the need to achieve an ethically acceptable balance between the
      principle of equality and principle of merit and concludes with four ethical
      standards to focus the terms of the debate.
FAU - Buchanan, David R
AU  - Buchanan DR
AD  - School of Public Health & Health Sciences, University of Massachusetts, Amherst, 
      MA 01003, USA. Buchanan@schoolph.umass.edu
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - Netherlands
TA  - J Prim Prev
JT  - The journal of primary prevention
JID - 8213457
SB  - IM
CON - J Prim Prev. 2011 Feb;32(1):3-15. PMID: 21274748
CIN - J Prim Prev. 2011 Feb;32(1):1-2. PMID: 21318466
CIN - J Prim Prev. 2011 Feb;32(1):23-7. PMID: 21438189
MH  - Cost Control/ethics/methods
MH  - *Health Behavior
MH  - *Health Care Costs
MH  - Health Care Reform/economics/*ethics
MH  - Health Insurance Portability and Accountability Act/standards
MH  - Humans
MH  - Insurance, Health/economics/*ethics
MH  - Rate Setting and Review/ethics/legislation & jurisprudence/standards
MH  - United States
EDAT- 2011/02/11 06:00
MHDA- 2011/07/12 06:00
CRDT- 2011/02/11 06:00
PHST- 2011/02/11 06:00 [entrez]
PHST- 2011/02/11 06:00 [pubmed]
PHST- 2011/07/12 06:00 [medline]
AID - 10.1007/s10935-011-0235-y [doi]
PST - ppublish
SO  - J Prim Prev. 2011 Feb;32(1):17-21. doi: 10.1007/s10935-011-0235-y.


PMID- 21307720
OWN - NLM
STAT- MEDLINE
DCOM- 20110325
LR  - 20181201
IS  - 1529-8809 (Electronic)
IS  - 0022-5282 (Linking)
VI  - 70
IP  - 2
DP  - 2011 Feb
TI  - Service: 2010 Western Trauma Association presidential address.
PG  - 267-72
LID - 10.1097/TA.0b013e318203157a [doi]
AB  - Service is central to the mission of a trauma surgeon and inextricably interwoven
      into our professional lives and activities. It is important to recognize the role
      that professional associations play in leveraging service as well as the need to 
      continue to cultivate the ethic of service in medical education and in our
      training programs.
FAU - Mackersie, Robert C
AU  - Mackersie RC
AD  - Department of Surgery, San Francisco General Hospital and Trauma Center,
      University of California San Francisco, San Francisco, California 94110, USA.
      rmackersie@sfghsurg.ucsf.edu
LA  - eng
PT  - Address
PL  - United States
TA  - J Trauma
JT  - The Journal of trauma
JID - 0376373
SB  - IM
MH  - Humans
MH  - Social Responsibility
MH  - Societies, Medical
MH  - *Traumatology/education/ethics/organization & administration
MH  - United States
EDAT- 2011/02/11 06:00
MHDA- 2011/03/26 06:00
CRDT- 2011/02/11 06:00
PHST- 2011/02/11 06:00 [entrez]
PHST- 2011/02/11 06:00 [pubmed]
PHST- 2011/03/26 06:00 [medline]
AID - 10.1097/TA.0b013e318203157a [doi]
AID - 00005373-201102000-00001 [pii]
PST - ppublish
SO  - J Trauma. 2011 Feb;70(2):267-72. doi: 10.1097/TA.0b013e318203157a.


PMID- 21307111
OWN - NLM
STAT- MEDLINE
DCOM- 20110308
LR  - 20181023
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 342
DP  - 2011 Feb 9
TI  - Withholding versus withdrawal of life support: is there an ethical difference?
PG  - d728
LID - 10.1136/bmj.d728 [doi]
LID - bmj.d728 [pii]
FAU - Glick, Shimon
AU  - Glick S
AD  - Lord Rabbi Immanuel Jakobovits Center for Jewish Medical Ethics, Joyce and Irving
      Goldman School of Medicine, Ben-Gurion University, Beer-Sheva, Israel.
      gshimon@bgu.ac.il
LA  - eng
PT  - Journal Article
DEP - 20110209
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Ethics, Medical
MH  - Humans
MH  - Life Support Care/*ethics
MH  - Withholding Treatment/*ethics
EDAT- 2011/02/11 06:00
MHDA- 2011/03/09 06:00
CRDT- 2011/02/11 06:00
PHST- 2011/02/11 06:00 [entrez]
PHST- 2011/02/11 06:00 [pubmed]
PHST- 2011/03/09 06:00 [medline]
AID - 10.1136/bmj.d728 [doi]
PST - epublish
SO  - BMJ. 2011 Feb 9;342:d728. doi: 10.1136/bmj.d728.


PMID- 21306841
OWN - NLM
STAT- MEDLINE
DCOM- 20110408
LR  - 20181201
IS  - 1872-6232 (Electronic)
IS  - 0378-3782 (Linking)
VI  - 87 Suppl 1
DP  - 2011 Mar
TI  - Nurses' ethical problems in the care of extremely low birth weight infants.
PG  - S85-6
LID - 10.1016/j.earlhumdev.2011.01.039 [doi]
FAU - Guardione, Roberta
AU  - Guardione R
AD  - Neonatology and NICU, S. Anna Hospital, Turin, Italy. robertaguardione@libero.it
FAU - Boano, Elena
AU  - Boano E
FAU - Di Maio, Pasquale
AU  - Di Maio P
FAU - Catarinella, Alessia
AU  - Catarinella A
FAU - Romano, Cristina
AU  - Romano C
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Ireland
TA  - Early Hum Dev
JT  - Early human development
JID - 7708381
SB  - IM
MH  - *Ethics, Nursing
MH  - Humans
MH  - *Infant, Extremely Low Birth Weight
MH  - Infant, Newborn
MH  - Intensive Care Units, Neonatal/ethics
MH  - Nurses
MH  - Pediatric Nursing/*ethics
MH  - Workforce
EDAT- 2011/02/11 06:00
MHDA- 2011/04/09 06:00
CRDT- 2011/02/11 06:00
PHST- 2011/02/11 06:00 [entrez]
PHST- 2011/02/11 06:00 [pubmed]
PHST- 2011/04/09 06:00 [medline]
AID - S0378-3782(11)00076-4 [pii]
AID - 10.1016/j.earlhumdev.2011.01.039 [doi]
PST - ppublish
SO  - Early Hum Dev. 2011 Mar;87 Suppl 1:S85-6. doi: 10.1016/j.earlhumdev.2011.01.039.


PMID- 21306817
OWN - NLM
STAT- MEDLINE
DCOM- 20110928
LR  - 20121115
IS  - 1432-0436 (Electronic)
IS  - 0301-4681 (Linking)
VI  - 81
IP  - 5
DP  - 2011 Jun
TI  - Human parthenogenetic stem cells produce enriched populations of definitive
      endoderm cells after trichostatin A pretreatment.
PG  - 292-8
LID - 10.1016/j.diff.2011.01.002 [doi]
AB  - Human parthenogenetic stem cells (hpSC) hold great promise as a source of
      pluripotent stem cells for cell-based transplantation therapy due to their
      ethical method of derivation as well as the enhanced capacity for immunomatching 
      with significant segments of the human population. We report here the directed
      differentiation of hpSC to produce enriched populations of definitive endoderm.
      Moreover, we find that treatment of undifferentiated hpSC by trichostatin A (TSA)
      before applying the directed differentiation protocol significantly increases the
      proportion of definitive endoderm cells in the final population. TSA-pretreated
      as well as non-TSA-treated hpSC undergoing differentiation toward definitive
      endoderm demonstrate a similar temporal sequence of gene expression to that which
      occurs in the course of definitive endoderm differentiation during vertebrate
      gastrulation and for differentiation of hESCs to definitive endoderm. Creation of
      the definitive endoderm lineages from hpSC represents the critical first step
      toward the development of hpSC-based cellular therapies for diseases of the liver
      or pancreas.
CI  - Copyright (c) 2011 International Society of Differentiation. Published by
      Elsevier B.V. All rights reserved.
FAU - Turovets, Nikolay
AU  - Turovets N
AD  - International Stem Cell Corporation, Oceanside, CA 92056, USA.
      nturovets@intlstemcell.com
FAU - D'Amour, Kevin A
AU  - D'Amour KA
FAU - Agapov, Vladimir
AU  - Agapov V
FAU - Turovets, Irina
AU  - Turovets I
FAU - Kochetkova, Olga
AU  - Kochetkova O
FAU - Janus, Jeffrey
AU  - Janus J
FAU - Semechkin, Andrey
AU  - Semechkin A
FAU - Moorman, Mark A
AU  - Moorman MA
FAU - Agapova, Larissa
AU  - Agapova L
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110208
PL  - England
TA  - Differentiation
JT  - Differentiation; research in biological diversity
JID - 0401650
RN  - 0 (Hydroxamic Acids)
RN  - 3X2S926L3Z (trichostatin A)
SB  - IM
MH  - Cell Culture Techniques/methods
MH  - Cell Differentiation/*drug effects/genetics
MH  - Cell Lineage
MH  - Cells, Cultured
MH  - Embryonic Stem Cells/cytology/*metabolism
MH  - Endoderm/*cytology/*metabolism
MH  - Humans
MH  - Hydroxamic Acids/*pharmacology
MH  - Parthenogenesis/*genetics
MH  - Pluripotent Stem Cells/cytology/metabolism
MH  - Stem Cells/cytology/metabolism
EDAT- 2011/02/11 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/02/11 06:00
PHST- 2010/02/11 00:00 [received]
PHST- 2010/11/12 00:00 [revised]
PHST- 2011/01/09 00:00 [accepted]
PHST- 2011/02/11 06:00 [entrez]
PHST- 2011/02/11 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - S0301-4681(11)00012-0 [pii]
AID - 10.1016/j.diff.2011.01.002 [doi]
PST - ppublish
SO  - Differentiation. 2011 Jun;81(5):292-8. doi: 10.1016/j.diff.2011.01.002. Epub 2011
      Feb 8.


PMID- 21306794
OWN - NLM
STAT- MEDLINE
DCOM- 20120322
LR  - 20141120
IS  - 1532-818X (Electronic)
IS  - 0196-0709 (Linking)
VI  - 32
IP  - 6
DP  - 2011 Nov-Dec
TI  - Endoscopic repair of Zenker's diverticulum by harmonic scalpel.
PG  - 553-6
LID - 10.1016/j.amjoto.2010.11.009 [doi]
AB  - PURPOSE: Although endoscopic staple-assisted esophagodiverticulostomy (ESED) has 
      become the initial treatment of choice for most patients with Zenker's
      diverticulum (ZD), anatomical restraints prevent its use in all cases. We
      describe an endoscopic approach for treating ZD using the harmonic scalpel, which
      can be used in certain cases where diverticulum anatomy precludes ESED. MATERIALS
      AND METHODS: Medical records of 7 consecutive patients who underwent endoscopic
      repair of ZD using the harmonic scalpel (Harmonic Ace, Ethicon Endo-Surgery, Inc,
      Cincinnati, OH) were reviewed. Data collected included demographics, symptoms,
      surgical details, complications, and postoperative outcomes. Main outcome
      measures were time to resumption of oral diet, symptom resolution, and
      complications. RESULTS: All patients (N = 7) who underwent endoscopic repair of
      ZD using the harmonic scalpel resumed an oral diet at initial follow-up visit
      after surgery (mean, 7 days; range, 4-9 days) and rated their symptoms as being
      completely resolved at subsequent follow-up (mean, 4 months; range, 1.5-8
      months). There were no complications. CONCLUSIONS: Endoscopic repair of ZD using 
      the ultrasonic cutting shears is a safe and efficacious procedure that allows for
      endoscopic treatment in certain cases that cannot be treated by ESED. Further
      study is warranted in larger series to determine efficacy and safety compared
      with established endoscopic techniques.
CI  - Published by Elsevier Inc.
FAU - May, James T 4th
AU  - May JT 4th
AD  - Department of Otolaryngology-Head and Neck Surgery, University of South Florida, 
      Tampa, FL, USA. jmay@health.usf.edu
FAU - Padhya, Tapan A
AU  - Padhya TA
FAU - McCaffrey, Thomas V
AU  - McCaffrey TV
LA  - eng
PT  - Journal Article
DEP - 20110208
PL  - United States
TA  - Am J Otolaryngol
JT  - American journal of otolaryngology
JID - 8000029
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Endoscopy/*instrumentation/methods
MH  - Esophagoscopy/methods
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Length of Stay
MH  - Male
MH  - Minimally Invasive Surgical Procedures/methods
MH  - Pain Measurement
MH  - Pain, Postoperative/physiopathology
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Sampling Studies
MH  - *Surgical Instruments
MH  - Treatment Outcome
MH  - Ultrasonic Surgical Procedures/*instrumentation/methods
MH  - Zenker Diverticulum/diagnosis/*surgery
EDAT- 2011/02/11 06:00
MHDA- 2012/03/23 06:00
CRDT- 2011/02/11 06:00
PHST- 2010/07/24 00:00 [received]
PHST- 2010/11/19 00:00 [accepted]
PHST- 2011/02/11 06:00 [entrez]
PHST- 2011/02/11 06:00 [pubmed]
PHST- 2012/03/23 06:00 [medline]
AID - S0196-0709(10)00241-3 [pii]
AID - 10.1016/j.amjoto.2010.11.009 [doi]
PST - ppublish
SO  - Am J Otolaryngol. 2011 Nov-Dec;32(6):553-6. doi: 10.1016/j.amjoto.2010.11.009.
      Epub 2011 Feb 8.


PMID- 21306645
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20211020
IS  - 1466-609X (Electronic)
IS  - 1364-8535 (Linking)
VI  - 15
IP  - 1
DP  - 2011
TI  - Implications of ICU triage decisions on patient mortality: a cost-effectiveness
      analysis.
PG  - R56
LID - 10.1186/cc10029 [doi]
AB  - INTRODUCTION: Intensive care is generally regarded as expensive, and as a result 
      beds are limited. This has raised serious questions about rationing when there
      are insufficient beds for all those referred. However, the evidence for the cost 
      effectiveness of intensive care is weak and the work that does exist usually
      assumes that those who are not admitted do not survive, which is not always the
      case. Randomised studies of the effectiveness of intensive care are difficult to 
      justify on ethical grounds; therefore, this observational study examined the cost
      effectiveness of ICU admission by comparing patients who were accepted into ICU
      after ICU triage to those who were not accepted, while attempting to adjust such 
      comparison for confounding factors. METHODS: This multi-centre observational
      cohort study involved 11 hospitals in 7 EU countries and was designed to assess
      the cost effectiveness of admission to intensive care after ICU triage. A total
      of 7,659 consecutive patients referred to the intensive care unit (ICU) were
      divided into those accepted for admission and those not accepted. The two groups 
      were compared in terms of cost and mortality using multilevel regression models
      to account for differences across centres, and after adjusting for age, Karnofsky
      score and indication for ICU admission. The analyses were also stratified by
      categories of Simplified Acute Physiology Score (SAPS) II predicted mortality (< 
      5%, 5% to 40% and >40%). Cost effectiveness was evaluated as cost per life saved 
      and cost per life-year saved. RESULTS: Admission to ICU produced a relative
      reduction in mortality risk, expressed as odds ratio, of 0.70 (0.52 to 0.94) at
      28 days. When stratified by predicted mortality, the odds ratio was 1.49 (0.79 to
      2.81), 0.7 (0.51 to 0.97) and 0.55 (0.37 to 0.83) for <5%, 5% to 40% and >40%
      predicted mortality, respectively. Average cost per life saved for all patients
      was $103,771 (euro82,358) and cost per life-year saved was $7,065 (euro5,607).
      These figures decreased substantially for patients with predicted mortality
      higher than 40%, $60,046 (euro47,656) and $4,088 (euro3,244), respectively.
      Results were very similar when considering three-month mortality. Sensitivity
      analyses performed to assess the robustness of the results provided findings
      similar to the main analyses. CONCLUSIONS: Not only does ICU appear to produce an
      improvement in survival, but the cost per life saved falls for patients with
      greater severity of illness. This suggests that intensive care is similarly cost 
      effective to other therapies that are generally regarded as essential.
FAU - Edbrooke, David L
AU  - Edbrooke DL
AD  - Medical and Economics Research Centre Sheffield, Royal Hallamshire Hospital,
      Sheffield Teaching Hospitals NHS Trust, Glossop Road, Sheffield S10 2JF, UK.
FAU - Minelli, Cosetta
AU  - Minelli C
FAU - Mills, Gary H
AU  - Mills GH
FAU - Iapichino, Gaetano
AU  - Iapichino G
FAU - Pezzi, Angelo
AU  - Pezzi A
FAU - Corbella, Davide
AU  - Corbella D
FAU - Jacobs, Philip
AU  - Jacobs P
FAU - Lippert, Anne
AU  - Lippert A
FAU - Wiis, Joergen
AU  - Wiis J
FAU - Pesenti, Antonio
AU  - Pesenti A
FAU - Patroniti, Nicolo
AU  - Patroniti N
FAU - Pirracchio, Romain
AU  - Pirracchio R
FAU - Payen, Didier
AU  - Payen D
FAU - Gurman, Gabriel
AU  - Gurman G
FAU - Bakker, Jan
AU  - Bakker J
FAU - Kesecioglu, Jozef
AU  - Kesecioglu J
FAU - Hargreaves, Chris
AU  - Hargreaves C
FAU - Cohen, Simon L
AU  - Cohen SL
FAU - Baras, Mario
AU  - Baras M
FAU - Artigas, Antonio
AU  - Artigas A
FAU - Sprung, Charles L
AU  - Sprung CL
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20110209
PL  - England
TA  - Crit Care
JT  - Critical care (London, England)
JID - 9801902
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cost-Benefit Analysis
MH  - Europe/epidemiology
MH  - Female
MH  - Health Resources/*statistics & numerical data
MH  - *Hospital Mortality
MH  - Humans
MH  - Intensive Care Units/*economics/statistics & numerical data
MH  - Male
MH  - Middle Aged
MH  - Patient Admission/*statistics & numerical data
MH  - Patients' Rooms/*economics/statistics & numerical data
MH  - Risk Assessment
MH  - Treatment Outcome
MH  - *Triage
PMC - PMC3221989
EDAT- 2011/02/11 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/02/11 06:00
PHST- 2009/06/26 00:00 [received]
PHST- 2010/09/01 00:00 [revised]
PHST- 2011/02/09 00:00 [accepted]
PHST- 2011/02/11 06:00 [entrez]
PHST- 2011/02/11 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - cc10029 [pii]
AID - 10.1186/cc10029 [doi]
PST - ppublish
SO  - Crit Care. 2011;15(1):R56. doi: 10.1186/cc10029. Epub 2011 Feb 9.


PMID- 21306470
OWN - NLM
STAT- MEDLINE
DCOM- 20110718
LR  - 20161125
IS  - 1524-4741 (Electronic)
IS  - 1075-122X (Linking)
VI  - 17
IP  - 2
DP  - 2011 Mar-Apr
TI  - Sonobreast: predicting individualized probabilities of malignancy in solid breast
      masses with echographic expression.
PG  - 152-9
LID - 10.1111/j.1524-4741.2010.01046.x [doi]
AB  - To create an individualized predictive tool for the risk of malignancy in solid
      breast masses, based on echographic and clinical characteristics. Research Ethics
      Committee approval and informed consent were obtained. This multi-center study
      included 1,403 solid breast masses prospectively. Each ultrasound feature was
      analyzed and compared with the definitive diagnosis. The ultrasound results,
      women's ages and family histories of breast cancer were included in a
      multivariate logistic regression model. Among the 1,403 lesions included in the
      study, 1,390 (99.1%) had a conclusive diagnosis: 343 malignant tumors (24.7%),
      and 1,047 benign masses (75.3%). The odds ratio (and confidence interval) for
      breast malignancy for each variable included in the model, as calculated by
      multivariate analysis, were as follows: irregular shape/noncircumscribed margins,
      16.02 (7.75-33.09); heterogeneous echo texture, 4.50 (2.42-8.23); vertical
      orientation (not parallel to the skin), 2.23 (1.04-4.75); anterior echogenic rim,
      2.62 (1.09-6.31); posterior shadowing, 2.38 (1.23-4.62); age more than 40 years, 
      2.19 (1.26-3.81); positive first-degree family history (mother, sister or
      daughter), 7.50 (2.65-21.18). There was no advantage in including the presence of
      internal vascularity, presence of thickened Cooper's ligaments or size of the
      mass, in the model. The predictive tool was named SONOBREAST and it is freely
      available for medical purposes on the internet site: http://www.sonobreast.com.
      The probability of malignancy in breast masses can be specified based on their
      ultrasound features, the woman's age and the family history of breast cancer.
CI  - (c) 2011 Wiley Periodicals, Inc.
FAU - Paulinelli, Regis Resende
AU  - Paulinelli RR
AD  - Department of Gynecology and Obstetrics, School of Medicine of the Federal
      University of Goias, Brazil. rrpaulinelli@gmail.com
FAU - Freitas-Junior, Ruffo
AU  - Freitas-Junior R
FAU - de Lucena, Clecio Enio Murta
AU  - de Lucena CE
FAU - Moreira, Marise Amaral Reboucas
AU  - Moreira MA
FAU - de Moraes, Vardeli Alves
AU  - de Moraes VA
FAU - Bernardes-Junior, Julio Roberto Macedo
AU  - Bernardes-Junior JR
FAU - da Silva Rocha Vidal, Celio
AU  - da Silva Rocha Vidal C
FAU - Ruiz, Alessandro Naldi
AU  - Ruiz AN
FAU - Lucato, Miliana Tostes
AU  - Lucato MT
FAU - da Costa, Nayara Gomes Silveira
AU  - da Costa NG
FAU - Teixeira, Danilo Augusto
AU  - Teixeira DA
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20110210
PL  - United States
TA  - Breast J
JT  - The breast journal
JID - 9505539
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Breast Neoplasms/*diagnostic imaging/genetics
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Medical Records
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Odds Ratio
MH  - Predictive Value of Tests
MH  - Probability
MH  - Prospective Studies
MH  - *Ultrasonography, Mammary
MH  - Young Adult
EDAT- 2011/02/11 06:00
MHDA- 2011/07/19 06:00
CRDT- 2011/02/11 06:00
PHST- 2011/02/11 06:00 [entrez]
PHST- 2011/02/11 06:00 [pubmed]
PHST- 2011/07/19 06:00 [medline]
AID - 10.1111/j.1524-4741.2010.01046.x [doi]
PST - ppublish
SO  - Breast J. 2011 Mar-Apr;17(2):152-9. doi: 10.1111/j.1524-4741.2010.01046.x. Epub
      2011 Feb 10.


PMID- 21306391
OWN - NLM
STAT- MEDLINE
DCOM- 20110607
LR  - 20110916
IS  - 1744-6198 (Electronic)
IS  - 0029-6473 (Linking)
VI  - 46
IP  - 1
DP  - 2011 Jan-Mar
TI  - Family nursing: walking the talk.
PG  - 11-21
LID - 10.1111/j.1744-6198.2010.00202.x [doi]
AB  - This article discusses a study exploring the lived experience of family nursing
      for novice registered nurses. There has been an increased emphasis on including
      family content in Canadian nursing education curricula. Literature on family
      nursing is ambiguous about differentiating family nursing at the generalist and
      specialist level, and acknowledges that there is a blurring of lines between the 
      two. The study utilized a phenomenological approach to examine how nurses with 2 
      years or less in practice experience family nursing in a variety of settings.
      Following ethical approval, invitations were sent to all nurses employed in two
      health authorities, who met the study criteria. Five nurses were interviewed
      using a semistructured interview. Participants shared how they practice family
      nursing in the current nursing situation of shortages and constraints. This study
      adds to our understanding of what happens at a beginning level of family nursing,
      how nurses understand and experience caring for families in the everyday
      enactment of their professional role, and barriers and facilitators to including 
      family in nursing care. The findings provide important information for nurse
      educators in grounding the teaching of family nursing in the real world of
      nurses.
CI  - (c) 2011 Wiley Periodicals, Inc.
FAU - Braun, Viola Fast
AU  - Braun VF
AD  - School of Health Studies, Brandon University, Manitoba, Canada.
      bobviola@goinet.ca
FAU - Foster, Cathy
AU  - Foster C
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Nurs Forum
JT  - Nursing forum
JID - 0401006
MH  - Canada
MH  - Family Nursing/*methods
MH  - Humans
MH  - *Nurse-Patient Relations
MH  - Nursing Methodology Research
MH  - Nursing Staff/*psychology
EDAT- 2011/02/11 06:00
MHDA- 2011/06/08 06:00
CRDT- 2011/02/11 06:00
PHST- 2011/02/11 06:00 [entrez]
PHST- 2011/02/11 06:00 [pubmed]
PHST- 2011/06/08 06:00 [medline]
AID - 10.1111/j.1744-6198.2010.00202.x [doi]
PST - ppublish
SO  - Nurs Forum. 2011 Jan-Mar;46(1):11-21. doi: 10.1111/j.1744-6198.2010.00202.x.


PMID- 21306079
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20151119
IS  - 8750-2186 (Print)
IS  - 8750-2186 (Linking)
VI  - 30
IP  - 1
DP  - 2011 Jan
TI  - Ethical considerations for adjunctive screening technologies.
PG  - 172, 174-5
FAU - Huff, Kevin
AU  - Huff K
AD  - Department of Comprehensive Care, Case School of Dental Medicine, Cleveland, OH, 
      USA. dr@doctorhuff.net
FAU - Huff, Marlene
AU  - Huff M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Dent Today
JT  - Dentistry today
JID - 9005357
MH  - Diagnosis, Oral/*ethics/*instrumentation
MH  - *Ethics, Dental
MH  - Female
MH  - Fluorescence
MH  - Humans
MH  - Light
MH  - Mass Screening/ethics
MH  - Middle Aged
MH  - Mouth Neoplasms/*diagnosis/surgery
MH  - Papilloma/diagnosis/surgery
MH  - Precancerous Conditions/diagnosis/surgery
MH  - Technology, Dental/*ethics
EDAT- 2011/02/11 06:00
MHDA- 2011/02/25 06:00
CRDT- 2011/02/11 06:00
PHST- 2011/02/11 06:00 [entrez]
PHST- 2011/02/11 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
PST - ppublish
SO  - Dent Today. 2011 Jan;30(1):172, 174-5.


PMID- 21306061
OWN - NLM
STAT- MEDLINE
DCOM- 20110301
LR  - 20191027
IS  - 1553-7250 (Print)
IS  - 1553-7250 (Linking)
VI  - 37
IP  - 1
DP  - 2011 Jan
TI  - Developing a policy for do not resuscitate orders within a framework of goals of 
      care.
PG  - 11-9
AB  - BACKGROUND: Discussions about DNR (do not resuscitate) orders or code status are 
      common but can be difficult and may not lead to accurate understanding between
      clinicians and patients. These discussion are often isolated from the larger
      context of a patient's plan of care. Addressing patients goals of care, which
      provide a basic orientation for clinical and ethical decision making, may improve
      clinicians' understanding about patients' code-status preferences. A POLICY FOR
      DNR ORDERS WITHIN A FRAMEWORK OF GOALS OF CARE: On the basis of experience at the
      University of Iowa Hospitals and Clinics, which entailed incorporating goals of
      care in ethics education, identifying six goals of care through a structured
      literature review, surveying hospitalized adults, and integrating goals of care
      into palliative care education, the University of Iowa Hospitals and Clinics
      ethics committee revised the hospital policy regarding DNR orders. The intention 
      was to avoid treating DNR orders as an isolated clinical phenomenon and to
      instead place the discussion of DNR orders in the more general context of
      end-of-life discussions and to place both of these discussions within an even
      more general framework of goals of care. CONCLUSIONS: The DNR order policy
      represents an effort to translate conceptual analysis, empirical research, and
      clinical experience into hospital policy so that clinicians are encouraged to
      place code-status discussions within a larger, goal-oriented context. Using goals
      of care to guide decision making about DNR orders and other treatments should
      enhance the quality of patient care by improving the fit between the biomedical
      information we provide patients and the values our patients rely on to make their
      medical decisions.
FAU - Kaldjian, Lauris C
AU  - Kaldjian LC
AD  - Division of General Internal Medicine, Department of Internal Medicine,
      University of Iowa Carver College of Medicine, Iowa City, USA.
      lauris-kaldjian@uiowa.edu
FAU - Broderick, Ann
AU  - Broderick A
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Jt Comm J Qual Patient Saf
JT  - Joint Commission journal on quality and patient safety
JID - 101238023
SB  - IM
MH  - Decision Making
MH  - Hospital Administration/*ethics
MH  - Humans
MH  - Palliative Care/ethics/organization & administration
MH  - Patient Care Planning/*ethics/*organization & administration
MH  - Policy
MH  - Resuscitation Orders/*ethics
MH  - Terminal Care/ethics/organization & administration
EDAT- 2011/02/11 06:00
MHDA- 2011/03/02 06:00
CRDT- 2011/02/11 06:00
PHST- 2011/02/11 06:00 [entrez]
PHST- 2011/02/11 06:00 [pubmed]
PHST- 2011/03/02 06:00 [medline]
AID - S1553-7250(11)37002-X [pii]
AID - 10.1016/s1553-7250(11)37002-x [doi]
PST - ppublish
SO  - Jt Comm J Qual Patient Saf. 2011 Jan;37(1):11-9. doi:
      10.1016/s1553-7250(11)37002-x.


PMID- 21306001
OWN - NLM
STAT- MEDLINE
DCOM- 20110303
LR  - 20110210
IS  - 0883-5381 (Print)
IS  - 0883-5381 (Linking)
VI  - 26
IP  - 1
DP  - 2011 Jan-Feb
TI  - Creating an ethical culture within the healthcare organization.
PG  - 98-9
CN  - American College of Healthcare Executives
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Healthc Exec
JT  - Healthcare executive
JID - 8612808
MH  - Health Facility Administration/*ethics
MH  - *Organizational Culture
MH  - United States
EDAT- 2011/02/11 06:00
MHDA- 2011/03/04 06:00
CRDT- 2011/02/11 06:00
PHST- 2011/02/11 06:00 [entrez]
PHST- 2011/02/11 06:00 [pubmed]
PHST- 2011/03/04 06:00 [medline]
PST - ppublish
SO  - Healthc Exec. 2011 Jan-Feb;26(1):98-9.


PMID- 21305654
OWN - NLM
STAT- MEDLINE
DCOM- 20111012
LR  - 20110426
IS  - 1098-1004 (Electronic)
IS  - 1059-7794 (Linking)
VI  - 32
IP  - 5
DP  - 2011 May
TI  - Initiating a Human Variome Project Country Node.
PG  - 501-6
LID - 10.1002/humu.21463 [doi]
AB  - Genetic diseases are a pressing global health problem that requires comprehensive
      access to basic clinical and genetic data to counter. The creation of regional
      and international databases that can be easily accessed by clinicians and
      diagnostic labs will greatly improve our ability to accurately diagnose and treat
      patients with genetic disorders. The Human Variome Project is currently working
      in conjunction with human genetics societies to achieve this by establishing
      systems to collect every mutation reported by a diagnostic laboratory, clinic, or
      research laboratory in a country and store these within a national repository, or
      HVP Country Node. Nodes have already been initiated in Australia, Belgium, China,
      Egypt, Malaysia, and Kuwait. Each is examining how to systematically collect and 
      share genetic, clinical, and biochemical information in a country-specific manner
      that is sensitive to local ethical and cultural issues. This article gathers
      cases of genetic data collection within countries and takes recommendations from 
      the global community to develop a procedure for countries wishing to establish
      their own collection system as part of the Human Variome Project. We hope this
      may lead to standard practices to facilitate global collection of data and allow 
      efficient use in clinical practice, research and therapy.
CI  - (c) 2011 Wiley-Liss, Inc.
FAU - AlAama, Jumana
AU  - AlAama J
AD  - Department of Genetic Medicine, Faculty of Medicine, King Abdulaziz University,
      Jeddah, Saudi Arabia.
FAU - Smith, Timothy D
AU  - Smith TD
FAU - Lo, Alan
AU  - Lo A
FAU - Howard, Heather
AU  - Howard H
FAU - Kline, Alexandria A
AU  - Kline AA
FAU - Lange, Matthew
AU  - Lange M
FAU - Kaput, Jim
AU  - Kaput J
FAU - Cotton, Richard G H
AU  - Cotton RG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110329
PL  - United States
TA  - Hum Mutat
JT  - Human mutation
JID - 9215429
SB  - IM
MH  - Data Collection/*methods
MH  - *Databases, Genetic
MH  - *Genetic Variation
MH  - Genome, Human/*genetics
MH  - Humans
MH  - Internationality
MH  - Mutation
MH  - National Health Programs
EDAT- 2011/02/10 06:00
MHDA- 2011/10/13 06:00
CRDT- 2011/02/10 06:00
PHST- 2011/01/10 00:00 [received]
PHST- 2011/01/24 00:00 [revised]
PHST- 2011/01/25 00:00 [accepted]
PHST- 2011/02/10 06:00 [entrez]
PHST- 2011/02/10 06:00 [pubmed]
PHST- 2011/10/13 06:00 [medline]
AID - 10.1002/humu.21463 [doi]
PST - ppublish
SO  - Hum Mutat. 2011 May;32(5):501-6. doi: 10.1002/humu.21463. Epub 2011 Mar 29.


PMID- 21305338
OWN - NLM
STAT- MEDLINE
DCOM- 20110909
LR  - 20110523
IS  - 1572-8358 (Electronic)
IS  - 0001-5342 (Linking)
VI  - 59
IP  - 2
DP  - 2011 Jun
TI  - Competing conceptions of animal welfare and their ethical implications for the
      treatment of non-human animals.
PG  - 105-20
LID - 10.1007/s10441-011-9124-2 [doi]
AB  - Animal welfare has been conceptualized in such a way that the use of animals in
      science and for food seems justified. I argue that those who have done this have 
      appropriated the concept of animal welfare, claiming to give a scientific account
      that is more objective than the "sentimental" account given by animal
      liberationists. This strategy seems to play a major role in supporting merely
      limited reform in the use of animals and seems to support the assumption that
      there are conditions under which animals may be raised and slaughtered for food
      that are ethically acceptable. Reformists do not need to make this assumption,
      but they tend to conceptualize animal welfare is such a way that death does not
      count as harmful to the interests of animals, nor prolonged life a benefit. In
      addition to this prudential value assumption, some members of this community have
      developed strategies for defending suitably reformed farming practices as ethical
      even granting that death and some other forms of constraints are harms. One such 
      strategy is the fiction of a domestic contract. However, if one accepts the
      conceptualization of human welfare give by L. W. Sumner, and applies it to
      animals in the way that I think is justified, an accurate conceptualization of
      animal welfare has different implications for which uses of animals should be
      regarded as ethically acceptable. In this paper I give an historical and
      philosophical account of animal welfare conceptulization and use this account to 
      argue that animal breeders, as custodians of the animals they breed, have the
      ethical responsibility to help their animal wards achieve as much autonomy as
      possible in choosing the form of life made available to them and to provide that 
      life. Attempts to avoid these implications by alluding to a contract model of the
      relationship between custodians and their wards fail to relieve custodians of
      their ethical responsibilities of care.
FAU - Haynes, Richard P
AU  - Haynes RP
AD  - Philosophy Department, University of Florida, Gainesville, 32611-8545, USA.
      rphaynes@ufl.edu
LA  - eng
PT  - Journal Article
DEP - 20110209
PL  - Netherlands
TA  - Acta Biotheor
JT  - Acta biotheoretica
JID - 0421520
SB  - IM
MH  - Agriculture/*ethics/trends
MH  - Animal Experimentation/*ethics
MH  - Animal Husbandry
MH  - Animal Rights
MH  - Animal Welfare/*ethics
MH  - Animals
MH  - Ethical Theory
MH  - Ethics
MH  - *Ethics, Research
MH  - Food
MH  - Meat
MH  - Models, Theoretical
MH  - Philosophy
EDAT- 2011/02/10 06:00
MHDA- 2011/09/10 06:00
CRDT- 2011/02/10 06:00
PHST- 2011/01/06 00:00 [received]
PHST- 2011/01/27 00:00 [accepted]
PHST- 2011/02/10 06:00 [entrez]
PHST- 2011/02/10 06:00 [pubmed]
PHST- 2011/09/10 06:00 [medline]
AID - 10.1007/s10441-011-9124-2 [doi]
PST - ppublish
SO  - Acta Biotheor. 2011 Jun;59(2):105-20. doi: 10.1007/s10441-011-9124-2. Epub 2011
      Feb 9.


PMID- 21305061
OWN - NLM
STAT- MEDLINE
DCOM- 20110802
LR  - 20220409
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 6
IP  - 1
DP  - 2011 Jan 31
TI  - Executive decision-making in the domestic sheep.
PG  - e15752
LID - 10.1371/journal.pone.0015752 [doi]
AB  - Two new large animal models of Huntington's disease (HD) have been developed
      recently, an old world monkey (macaque) and a sheep. Macaques, with their large
      brains and complex repertoire of behaviors are the 'gold-standard' laboratory
      animals for testing cognitive function, but there are many practical and ethical 
      issues that must be resolved before HD macaques can be used for pre-clinical
      research. By contrast, despite their comparable brain size, sheep do not enjoy a 
      reputation for intelligence, and are not used for pre-clinical cognitive testing.
      Given that cognitive decline is a major therapeutic target in HD, the feasibility
      of testing cognitive function in sheep must be explored if they are to be
      considered seriously as models of HD. Here we tested the ability of sheep to
      perform tests of executive function (discrimination learning, reversal learning
      and attentional set-shifting). Significantly, we found that not only could sheep 
      perform discrimination learning and reversals, but they could also perform the
      intradimensional (ID) and extradimensional (ED) set-shifting tasks that are
      sensitive tests of cognitive dysfunction in humans. Their performance on the
      ID/ED shifts mirrored that seen in humans and macaques, with significantly more
      errors to reach criterion in the ED than the ID shift. Thus, sheep can perform
      'executive' cognitive tasks that are an important part of the primate behavioral 
      repertoire, but which have never been shown previously to exist in any other
      large animal. Sheep have great potential, not only for use as a large animal
      model of HD, but also for studying cognitive function and the evolution of
      complex behaviours in normal animals.
FAU - Morton, A Jennifer
AU  - Morton AJ
AD  - Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom.
      ajm41@cam.ac.uk
FAU - Avanzo, Laura
AU  - Avanzo L
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110131
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Animals
MH  - Attention
MH  - *Cognition
MH  - Decision Making/*physiology
MH  - Discrimination Learning
MH  - Huntington Disease
MH  - *Models, Animal
MH  - Reversal Learning
MH  - Sheep, Domestic/*physiology
PMC - PMC3031539
EDAT- 2011/02/10 06:00
MHDA- 2011/08/04 06:00
CRDT- 2011/02/10 06:00
PHST- 2010/10/13 00:00 [received]
PHST- 2010/11/21 00:00 [accepted]
PHST- 2011/02/10 06:00 [entrez]
PHST- 2011/02/10 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
AID - 10.1371/journal.pone.0015752 [doi]
PST - epublish
SO  - PLoS One. 2011 Jan 31;6(1):e15752. doi: 10.1371/journal.pone.0015752.


PMID- 21304812
OWN - NLM
STAT- MEDLINE
DCOM- 20110901
LR  - 20211020
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 6
IP  - 2
DP  - 2011 Feb 3
TI  - Nestin-GFP transgene reveals neural precursor cells in adult skeletal muscle.
PG  - e16816
LID - 10.1371/journal.pone.0016816 [doi]
AB  - BACKGROUND: Therapy for neural lesions or degenerative diseases relies mainly on 
      finding transplantable active precursor cells. Identifying them in peripheral
      tissues accessible for biopsy, outside the central nervous system, would
      circumvent the serious immunological and ethical concerns impeding cell therapy. 
      METHODOLOGY/PRINCIPAL FINDINGS: In this study, we isolated neural progenitor
      cells in cultured adult skeletal muscle from transgenic mice in which nestin
      regulatory elements control GFP expression. These cells also expressed the early 
      neural marker Tuj1 and light and heavy neurofilament but not S100beta, indicating
      that they express typical neural but not Schwann cell markers. GFP+/Tuj1+ cells
      were also negative for the endothelial and pericyte markers CD31 and alpha-smooth
      muscle actin, respectively. We established their a) functional response to
      glutamate in patch-clamp recordings; b) interstitial mesenchymal origin; c)
      replicative capacity; and d) the environment necessary for their survival after
      fluorescence-activated cell sorting. CONCLUSIONS/SIGNIFICANCE: We propose that
      the decline in nestin-GFP expression in muscle progenitor cells and its
      persistence in neural precursor cells in muscle cultures provide an invaluable
      tool for isolating a population of predifferentiated neural cells with
      therapeutic potential.
FAU - Birbrair, Alexander
AU  - Birbrair A
AD  - Department of Internal Medicine-Gerontology, Wake Forest University School of
      Medicine, Winston-Salem, North Carolina, USA.
FAU - Wang, Zhong-Min
AU  - Wang ZM
FAU - Messi, Maria Laura
AU  - Messi ML
FAU - Enikolopov, Grigori N
AU  - Enikolopov GN
FAU - Delbono, Osvaldo
AU  - Delbono O
LA  - eng
GR  - R29 AG013934/AG/NIA NIH HHS/United States
GR  - R21 AG033385/AG/NIA NIH HHS/United States
GR  - R01 AG013934/AG/NIA NIH HHS/United States
GR  - R01 AG015820/AG/NIA NIH HHS/United States
GR  - P30 AG021332/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110203
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Intermediate Filament Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Nes protein, mouse)
RN  - 0 (Nestin)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 147336-22-9 (Green Fluorescent Proteins)
SB  - IM
MH  - Aging/metabolism/physiology
MH  - Animals
MH  - Cell Differentiation/genetics/physiology
MH  - Cell Tracking/methods
MH  - Cells, Cultured
MH  - Female
MH  - Flow Cytometry
MH  - Green Fluorescent Proteins/*genetics/metabolism/physiology
MH  - Intermediate Filament Proteins/*genetics/metabolism/physiology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Muscle, Skeletal/*cytology/metabolism
MH  - Nerve Tissue Proteins/*genetics/metabolism/physiology
MH  - Nestin
MH  - Neural Stem Cells/*cytology/*metabolism/physiology
MH  - Recombinant Fusion Proteins/genetics/metabolism/physiology
MH  - Transgenes/*physiology
PMC - PMC3033412
EDAT- 2011/02/10 06:00
MHDA- 2011/09/02 06:00
CRDT- 2011/02/10 06:00
PHST- 2010/09/26 00:00 [received]
PHST- 2011/01/11 00:00 [accepted]
PHST- 2011/02/10 06:00 [entrez]
PHST- 2011/02/10 06:00 [pubmed]
PHST- 2011/09/02 06:00 [medline]
AID - 10.1371/journal.pone.0016816 [doi]
PST - epublish
SO  - PLoS One. 2011 Feb 3;6(2):e16816. doi: 10.1371/journal.pone.0016816.


PMID- 21304377
OWN - NLM
STAT- MEDLINE
DCOM- 20110617
LR  - 20110209
IS  - 1534-4908 (Electronic)
IS  - 1530-4515 (Linking)
VI  - 21
IP  - 1
DP  - 2011 Feb
TI  - Laparoscopy-assisted right hepatectomy in a case of Fasciola hepatica.
PG  - e54-8
LID - 10.1097/SLE.0b013e318200a263 [doi]
AB  - Laparoscopic hepatectomy provides the usual advantages of a minimally invasive
      surgery. This study presents a case of Fasciola hepatica infection that was
      successfully treated with laparoscopic hepatectomy. The patient was referred
      because of persistent fever and right hypochondralgia with a huge mass occupying 
      the right lobe of the liver, which was detected by imaging analysis. Serologic
      tests indicated an F. hepatica infection. The patient underwent a laparoscopic
      resection because the anthelmintic agent, triclabendazole was not effective.
      During the surgical technique, 5 trocars were inserted. After liver mobilization,
      the Glissonian pedicles and right hepatic veins were safely taped. A Penrose
      drain was placed behind the liver for a liver-hanging maneuver. A liver
      parenchymal transection was performed through an 8 cm handport site using a
      dissecting sealer (TissueLink Medical) after precoagulating its superficial layer
      by microtaze. Glissonian pedicles and the right hepatic vein were divided using
      an endolinear stapler (endcutter 45, Ethicon). Finally, the resected specimen was
      extracted from the handport. The surgical time was 450 minutes and the surgical
      blood loss was 370 mL. The patient was discharged 10 days after the surgery with 
      an uneventful postoperative course. The laparoscopy-assisted hepatectomy in this 
      case was beneficial for the patient's quality of life as a minimally invasive
      operation with a high degree of safety.
FAU - Kawashita, Yujo
AU  - Kawashita Y
AD  - Department of Surgery, Nagasaki Rosai Hospital, Setogoshi, Nagasaki, Japan.
      yujongs@gmail.com
FAU - Iwata, Toru
AU  - Iwata T
FAU - Kanetaka, Kengo
AU  - Kanetaka K
FAU - Ono, Shinichiro
AU  - Ono S
FAU - Kawahara, Yasuhiro
AU  - Kawahara Y
FAU - Fujisawa, Hiroyuki
AU  - Fujisawa H
FAU - Yoshida, Toshiaki
AU  - Yoshida T
FAU - Miyahara, Shinichi
AU  - Miyahara S
FAU - Eto, Shozo
AU  - Eto S
FAU - Kanematsu, Takashi
AU  - Kanematsu T
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Surg Laparosc Endosc Percutan Tech
JT  - Surgical laparoscopy, endoscopy & percutaneous techniques
JID - 100888751
SB  - IM
MH  - Aged
MH  - Animals
MH  - Fasciola hepatica/*parasitology
MH  - Fascioliasis/blood/parasitology/*surgery
MH  - Female
MH  - Hepatectomy/instrumentation/*methods
MH  - Humans
MH  - Inflammation
MH  - Laparoscopy/instrumentation/*methods
EDAT- 2011/02/10 06:00
MHDA- 2011/06/18 06:00
CRDT- 2011/02/10 06:00
PHST- 2011/02/10 06:00 [entrez]
PHST- 2011/02/10 06:00 [pubmed]
PHST- 2011/06/18 06:00 [medline]
AID - 10.1097/SLE.0b013e318200a263 [doi]
AID - 00129689-201102000-00030 [pii]
PST - ppublish
SO  - Surg Laparosc Endosc Percutan Tech. 2011 Feb;21(1):e54-8. doi:
      10.1097/SLE.0b013e318200a263.


PMID- 21304005
OWN - NLM
STAT- MEDLINE
DCOM- 20120629
LR  - 20211020
IS  - 1748-880X (Electronic)
IS  - 0007-1285 (Linking)
VI  - 85
IP  - 1013
DP  - 2012 May
TI  - Virtual reality, ultrasound-guided liver biopsy simulator: development and
      performance discrimination.
PG  - 555-61
LID - 10.1259/bjr/47436030 [doi]
AB  - OBJECTIVES: The aim of this article was to identify and prospectively investigate
      simulated ultrasound-guided targeted liver biopsy performance metrics as
      differentiators between levels of expertise in interventional radiology. METHODS:
      Task analysis produced detailed procedural step documentation allowing
      identification of critical procedure steps and performance metrics for use in a
      virtual reality ultrasound-guided targeted liver biopsy procedure. Consultant
      (n=14; male=11, female=3) and trainee (n=26; male=19, female=7) scores on the
      performance metrics were compared. Ethical approval was granted by the Liverpool 
      Research Ethics Committee (UK). Independent t-tests and analysis of variance
      (ANOVA) investigated differences between groups. RESULTS: Independent t-tests
      revealed significant differences between trainees and consultants on three
      performance metrics: targeting, p=0.018, t=-2.487 (-2.040 to -0.207); probe usage
      time, p = 0.040, t=2.132 (11.064 to 427.983); mean needle length in beam,
      p=0.029, t=-2.272 (-0.028 to -0.002). ANOVA reported significant differences
      across years of experience (0-1, 1-2, 3+ years) on seven performance metrics:
      no-go area touched, p=0.012; targeting, p=0.025; length of session, p=0.024;
      probe usage time, p=0.025; total needle distance moved, p=0.038; number of skin
      contacts, p<0.001; total time in no-go area, p=0.008. More experienced
      participants consistently received better performance scores on all 19
      performance metrics. CONCLUSION: It is possible to measure and monitor
      performance using simulation, with performance metrics providing feedback on
      skill level and differentiating levels of expertise. However, a transfer of
      training study is required.
FAU - Johnson, S J
AU  - Johnson SJ
AD  - Manchester Business School, University of Manchester, UK.
      sheena.johnson@mbs.ac.uk
FAU - Hunt, C M
AU  - Hunt CM
FAU - Woolnough, H M
AU  - Woolnough HM
FAU - Crawshaw, M
AU  - Crawshaw M
FAU - Kilkenny, C
AU  - Kilkenny C
FAU - Gould, D A
AU  - Gould DA
FAU - England, A
AU  - England A
FAU - Sinha, A
AU  - Sinha A
FAU - Villard, P F
AU  - Villard PF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110208
PL  - England
TA  - Br J Radiol
JT  - The British journal of radiology
JID - 0373125
SB  - IM
MH  - Biopsy/methods
MH  - *Clinical Competence
MH  - *Computer Simulation
MH  - Educational Measurement/*methods
MH  - Female
MH  - Humans
MH  - Imaging, Three-Dimensional
MH  - Liver/*pathology
MH  - Male
MH  - Prospective Studies
MH  - Radiology, Interventional/*standards
MH  - Ultrasonography, Interventional
MH  - User-Computer Interface
PMC - PMC3479890
EDAT- 2011/02/10 06:00
MHDA- 2012/06/30 06:00
CRDT- 2011/02/10 06:00
PHST- 2011/02/10 06:00 [entrez]
PHST- 2011/02/10 06:00 [pubmed]
PHST- 2012/06/30 06:00 [medline]
AID - 47436030 [pii]
AID - 10.1259/bjr/47436030 [doi]
PST - ppublish
SO  - Br J Radiol. 2012 May;85(1013):555-61. doi: 10.1259/bjr/47436030. Epub 2011 Feb
      8.


PMID- 21303838
OWN - NLM
STAT- MEDLINE
DCOM- 20110603
LR  - 20110209
IS  - 1477-0962 (Electronic)
IS  - 0961-2033 (Linking)
VI  - 20
IP  - 2
DP  - 2011 Feb
TI  - Antiphospholipid Syndrome Clinical Research Task Force report.
PG  - 219-24
LID - 10.1177/0961203310395053 [doi]
AB  - The Antiphospholipid Syndrome (APS) Clinical Research Task Force (CRTF) was one
      of six Task Forces developed by the 13(th) International Congress on
      Antiphospholipid Antibodies (aPL) organization committee with the purpose of: a) 
      evaluating the limitations of APS clinical research and developing guidelines for
      researchers to help improve the quality of APS research; and b) prioritizing the 
      ideas for a well-designed multicenter clinical trial and discussing the
      pragmatics of getting such a trial done. Following a systematic working
      algorithm, the Task Force identified five major issues that impede APS clinical
      research and the ability to develop evidence-based recommendations for the
      management of aPL-positive patients: (1) aPL detection has been based on
      partially or non-standardized tests, and clinical (and basic) APS research
      studies have included patients with heterogeneous aPL profiles with different
      clinical event risks; (2) clinical (and basic) APS research studies have included
      a heterogeneous group of patients with different aPL-related manifestations (some
      controversial); (3) thrombosis and/or pregnancy risk stratification and
      quantification are rarely incorporated in APS clinical research; (4) most APS
      clinical studies include patients with single positive aPL results and/or
      low-titer aPL ELISA results; furthermore, study designs are mostly retrospective 
      and not population based, with limited number of prospective and/or controlled
      population studies; and (5) lack of the understanding the particular mechanisms
      of aPL-mediated clinical events limits the optimal clinical study design. The
      Task Force recommended that there is an urgent need for a truly international
      collaborative approach to design and conduct well-designed prospective
      large-scale multi-center clinical trials of patients with persistent and
      clinically significant aPL profiles. An international collaborative meeting to
      formulate a good research question using 'FINER' (Feasible; Interesting; Novel;
      Ethical; and Relevant) criteria took place in November 2010.
FAU - Erkan, D
AU  - Erkan D
AD  - Hospital for Special Surgery, Weill Medical College of Cornell University, New
      York, NY, USA. erkand@hss.edu
FAU - Derksen, R
AU  - Derksen R
FAU - Levy, R
AU  - Levy R
FAU - Machin, S
AU  - Machin S
FAU - Ortel, T
AU  - Ortel T
FAU - Pierangeli, S
AU  - Pierangeli S
FAU - Roubey, R
AU  - Roubey R
FAU - Lockshin, M
AU  - Lockshin M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Lupus
JT  - Lupus
JID - 9204265
RN  - 0 (Antibodies, Antiphospholipid)
SB  - IM
MH  - *Advisory Committees
MH  - Antibodies, Antiphospholipid
MH  - *Antiphospholipid Syndrome
MH  - *Biomedical Research
MH  - Clinical Trials as Topic
MH  - Congresses as Topic
MH  - Female
MH  - Humans
MH  - Pregnancy
EDAT- 2011/02/10 06:00
MHDA- 2011/06/04 06:00
CRDT- 2011/02/10 06:00
PHST- 2011/02/10 06:00 [entrez]
PHST- 2011/02/10 06:00 [pubmed]
PHST- 2011/06/04 06:00 [medline]
AID - 20/2/219 [pii]
AID - 10.1177/0961203310395053 [doi]
PST - ppublish
SO  - Lupus. 2011 Feb;20(2):219-24. doi: 10.1177/0961203310395053.


PMID- 21303504
OWN - NLM
STAT- MEDLINE
DCOM- 20110502
LR  - 20211020
IS  - 1747-5341 (Electronic)
IS  - 1747-5341 (Linking)
VI  - 6
DP  - 2011 Feb 8
TI  - The ethical and legal aspects of palliative sedation in severely brain-injured
      patients: a French perspective.
PG  - 4
LID - 10.1186/1747-5341-6-4 [doi]
AB  - To fulfill their crucial duty of relieving suffering in their patients,
      physicians may have to administer palliative sedation when they implement
      treatment-limitation decisions such as the withdrawal of life-supporting
      interventions in patients with poor prognosis chronic severe brain injury. The
      issue of palliative sedation deserves particular attention in adults with serious
      brain injuries and in neonates with severe and irreversible brain lesions, who
      are unable to express pain or to state their wishes. In France, treatment
      limitation decisions for these patients are left to the physicians.
      Treatment-limitation decisions are made collegially, based on the presence of
      irreversible brain lesions responsible for chronic severe disorders of
      consciousness. Before these decisions are implemented, they are communicated to
      the relatives. Because the presence and severity of pain cannot be assessed in
      these patients, palliative analgesia and/or sedation should be administered.
      However, palliative sedation is a complex strategy that requires safeguards to
      prevent a drift toward hastening death or performing covert euthanasia. In
      addition to the law on patients' rights at the end of life passed in France on
      April 22, 2005, a recent revision of Article 37 of the French code of medical
      ethics both acknowledges that treatment-limitation decisions and palliative
      sedation may be required in patients with severe brain injuries and provides
      legal and ethical safeguards against a shift towards euthanasia. This legislation
      may hold value as a model for other countries where euthanasia is illegal and for
      countries such as Belgium and Netherlands where euthanasia is legal but not
      allowed in patients incapable of asking for euthanasia but in whom a treatment
      limitation decision has been made.
FAU - Baumann, Antoine
AU  - Baumann A
AD  - Departement d'Anesthesie Reanimation, Hopital Central, Centre Hospitalier
      Universitaire de Nancy, France. a.baumann@chu-nancy.fr
FAU - Claudot, Frederique
AU  - Claudot F
FAU - Audibert, Gerard
AU  - Audibert G
FAU - Mertes, Paul-Michel
AU  - Mertes PM
FAU - Puybasset, Louis
AU  - Puybasset L
LA  - eng
PT  - Journal Article
DEP - 20110208
PL  - England
TA  - Philos Ethics Humanit Med
JT  - Philosophy, ethics, and humanities in medicine : PEHM
JID - 101258058
SB  - IM
MH  - Brain Injuries/*therapy
MH  - Deep Sedation/*ethics
MH  - Ethics, Medical
MH  - Euthanasia/ethics
MH  - France
MH  - Humans
MH  - *Legislation, Medical
MH  - Palliative Care/*ethics/legislation & jurisprudence
MH  - Suicide, Assisted/ethics
MH  - Terminal Care/*ethics
MH  - Tissue and Organ Procurement/ethics
PMC - PMC3041748
EDAT- 2011/02/10 06:00
MHDA- 2011/05/03 06:00
CRDT- 2011/02/10 06:00
PHST- 2010/07/29 00:00 [received]
PHST- 2011/02/08 00:00 [accepted]
PHST- 2011/02/10 06:00 [entrez]
PHST- 2011/02/10 06:00 [pubmed]
PHST- 2011/05/03 06:00 [medline]
AID - 1747-5341-6-4 [pii]
AID - 10.1186/1747-5341-6-4 [doi]
PST - epublish
SO  - Philos Ethics Humanit Med. 2011 Feb 8;6:4. doi: 10.1186/1747-5341-6-4.


PMID- 21303287
OWN - NLM
STAT- MEDLINE
DCOM- 20110527
LR  - 20110808
IS  - 1440-1665 (Electronic)
IS  - 1039-8562 (Linking)
VI  - 19
IP  - 1
DP  - 2011 Feb
TI  - Code of ethics: the time-bomb of clause 3.13.
PG  - 86
LID - 10.3109/10398562.2010.539229 [doi]
FAU - Morstyn, Ron
AU  - Morstyn R
LA  - eng
PT  - Comment
PT  - Letter
PL  - England
TA  - Australas Psychiatry
JT  - Australasian psychiatry : bulletin of Royal Australian and New Zealand College of
      Psychiatrists
JID - 9613603
SB  - IM
CON - Australas Psychiatry. 2010 Jun;18(3):221-5. PMID: 20429681
CIN - Australas Psychiatry. 2011 Jun;19(3):269. PMID: 21682629
MH  - Australia
MH  - Codes of Ethics/*trends
MH  - Data Interpretation, Statistical
MH  - Evidence-Based Medicine/*ethics
MH  - Psychiatry/*ethics
EDAT- 2011/02/10 06:00
MHDA- 2011/05/28 06:00
CRDT- 2011/02/10 06:00
PHST- 2011/02/10 06:00 [entrez]
PHST- 2011/02/10 06:00 [pubmed]
PHST- 2011/05/28 06:00 [medline]
AID - 10.3109/10398562.2010.539229 [doi]
PST - ppublish
SO  - Australas Psychiatry. 2011 Feb;19(1):86. doi: 10.3109/10398562.2010.539229.


PMID- 21303266
OWN - NLM
STAT- MEDLINE
DCOM- 20120127
LR  - 20220408
IS  - 1557-8534 (Electronic)
IS  - 1547-3287 (Linking)
VI  - 20
IP  - 8
DP  - 2011 Aug
TI  - Safety of intravenous infusion of human adipose tissue-derived mesenchymal stem
      cells in animals and humans.
PG  - 1297-308
LID - 10.1089/scd.2010.0466 [doi]
AB  - Adipose tissue-derived mesenchymal stem cells (AdMSCs) represent an attractive
      and ethical cell source for stem cell therapy. With the recent demonstration of
      MSC homing properties, intravenous applications of MSCs to cell-damaged diseases 
      have increased. In the present study, the toxicity and tumorigenicity of human
      AdMSCs (hAdMSCs) were investigated for clinical application. Culture-expanded
      hAdMSCs showed the typical appearance, immunophenotype, and differentiation
      capacity of MSCs, and were genetically stable at least 12 passages in culture.
      Cells suspended in physiological saline maintained their MSC properties in a cold
      storage condition for at least 3 days. To test the toxicity of hAdMSCs, different
      doses of hAdMSCs were injected intravenously into immunodeficient mice, and the
      mice were observed for 13 weeks. Even at the highest cell dose (2.5x10(8)
      cells/kg body weight), the SCID mice were viable and had no side effects. A
      tumorigenicity test was performed in Balb/c-nu nude mice for 26 weeks. Even at
      the highest cell dose (2x10(8) MSCs/kg), no evidence of tumor development was
      found. In a human clinical trial, 8 male patients who had suffered a spinal cord 
      injury >12 months previous were intravenously administered autologous hAdMSCs
      (4x10(8) cells) one time. None of the patients developed any serious adverse
      events related to hAdMSC transplantation during the 3-month follow-up. In
      conclusion, the systemic transplantation of hAdMSCs appears to be safe and does
      not induce tumor development.
FAU - Ra, Jeong Chan
AU  - Ra JC
AD  - Stem Cell Research Center, RNL Bio Co, Ltd, Seoul, Republic of Korea.
      jcra@rnl.co.kr
FAU - Shin, Il Seob
AU  - Shin IS
FAU - Kim, Sang Han
AU  - Kim SH
FAU - Kang, Sung Keun
AU  - Kang SK
FAU - Kang, Byeong Cheol
AU  - Kang BC
FAU - Lee, Hang Young
AU  - Lee HY
FAU - Kim, Youn Joung
AU  - Kim YJ
FAU - Jo, Jung Youn
AU  - Jo JY
FAU - Yoon, Eun Ji
AU  - Yoon EJ
FAU - Choi, Hyung Jun
AU  - Choi HJ
FAU - Kwon, Euna
AU  - Kwon E
LA  - eng
PT  - Clinical Trial, Phase I
PT  - Journal Article
DEP - 20110317
PL  - United States
TA  - Stem Cells Dev
JT  - Stem cells and development
JID - 101197107
RN  - 0 (Antigens, Surface)
SB  - IM
CIN - Stem Cells Dev. 2011 Aug;20(8):1295-6. PMID: 21510815
MH  - *Adipose Tissue/cytology/metabolism
MH  - Adult
MH  - Animals
MH  - Antigens, Surface
MH  - Carcinogenicity Tests
MH  - Cell Differentiation
MH  - Female
MH  - Humans
MH  - *Infusions, Intravenous
MH  - Karyotype
MH  - Male
MH  - Mesenchymal Stem Cell Transplantation/*adverse effects/*methods
MH  - Mesenchymal Stem Cells/cytology/physiology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Nude
MH  - Mice, SCID
MH  - Middle Aged
MH  - Neoplasms
MH  - Spinal Cord Injuries/*therapy
EDAT- 2011/02/10 06:00
MHDA- 2012/01/28 06:00
CRDT- 2011/02/10 06:00
PHST- 2011/02/10 06:00 [entrez]
PHST- 2011/02/10 06:00 [pubmed]
PHST- 2012/01/28 06:00 [medline]
AID - 10.1089/scd.2010.0466 [doi]
PST - ppublish
SO  - Stem Cells Dev. 2011 Aug;20(8):1297-308. doi: 10.1089/scd.2010.0466. Epub 2011
      Mar 17.


PMID- 21303265
OWN - NLM
STAT- MEDLINE
DCOM- 20140722
LR  - 20111102
IS  - 1545-1569 (Electronic)
IS  - 1055-6656 (Linking)
VI  - 48
IP  - 6
DP  - 2011 Nov
TI  - Flood, disaster, and turmoil: social issues in cleft and craniofacial care and
      crisis relief.
PG  - 750-6
LID - 10.1597/09-255 [doi]
AB  - OBJECTIVE: To examine social issues in the conduct of cleft and craniofacial care
      through relief programs in disrupted crisis contexts. METHOD: Social, health
      policy, and ethical analyses. RESULTS: At best, craniofacial team care is
      multidisciplinary, coordinated, and sustained, requiring a long-term relationship
      between team members, patients, and families. Disasters and societal turmoil
      interrupt such relationships, causing craniofacial care to become a secondary
      concern. Providing craniofacial team care in a crisis setting requires rebuilding
      disrupted coordination and communication. Crisis relief care involves a complex
      set of expectations and responsibilities and raises issues such as (1) quality
      assurance, infection control, appropriate standards of care, and follow-up
      care/continuity; (2) equity of access to services and clinical ethics in the
      context of war and/or deprivation; (3) training of visitors in the local nation
      or site; (4) disciplinary composition of teams, interprofessional
      communication/rivalry, and credentials of clinicians; (5) ownership of the site
      and local visitor relations; (6) fundraising and marketing strategies; and (7)
      ethical issues in the doctor-patient relationship. CONCLUSIONS: Specific ethical 
      standards for international cleft and craniofacial care delivery also apply to
      domestic and global crisis relief contexts. Guidance on issues related to
      professional experience, informed consent, and continuity of care will help care 
      providers address social and ethical issues raised in crisis relief programs.
      This paper proposes that the Position Paper of the American Cleft
      Palate-Craniofacial Association (ACPA) on International Treatment Programs should
      be used as a template to develop and disseminate a set of standards that apply to
      crisis relief.
FAU - Strauss, Ronald P
AU  - Strauss RP
FAU - van Aalst, John A
AU  - van Aalst JA
FAU - Fox, Lynn
AU  - Fox L
FAU - Stein, Margot
AU  - Stein M
FAU - Moses, Michael
AU  - Moses M
FAU - Cassell, Cynthia H
AU  - Cassell CH
LA  - eng
PT  - Journal Article
DEP - 20110208
PL  - United States
TA  - Cleft Palate Craniofac J
JT  - The Cleft palate-craniofacial journal : official publication of the American
      Cleft Palate-Craniofacial Association
JID - 9102566
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Cleft Lip/*therapy
MH  - Cleft Palate/*therapy
MH  - Delivery of Health Care/*organization & administration
MH  - Disaster Planning
MH  - *Disasters
MH  - Ethics, Medical
MH  - Female
MH  - Floods
MH  - Health Policy
MH  - Health Services Accessibility
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Interprofessional Relations
MH  - Male
MH  - Patient Care Team/organization & administration
MH  - Physician-Patient Relations
MH  - Quality Assurance, Health Care
MH  - Relief Work/*organization & administration
EDAT- 2011/02/10 06:00
MHDA- 2014/07/23 06:00
CRDT- 2011/02/10 06:00
PHST- 2011/02/10 06:00 [entrez]
PHST- 2011/02/10 06:00 [pubmed]
PHST- 2014/07/23 06:00 [medline]
AID - 10.1597/09-255 [doi]
PST - ppublish
SO  - Cleft Palate Craniofac J. 2011 Nov;48(6):750-6. doi: 10.1597/09-255. Epub 2011
      Feb 8.


PMID- 21285155
OWN - NLM
STAT- MEDLINE
DCOM- 20110325
LR  - 20200206
IS  - 1569-8041 (Electronic)
IS  - 0923-7534 (Linking)
VI  - 22 Suppl 1
DP  - 2011 Jan
TI  - Conclusions: fruits of the convergence of laboratory, clinic and public.
PG  - i67-8
LID - 10.1093/annonc/mdq669 [doi]
AB  - Genes implicated in the devastating occurrences of cancers mostly arising in the 
      breast and ovaries within certain 'high-risk' families were mapped and then
      cloned not even two decades ago. Some clairvoyant students of the subject
      anticipated that this 'assignation of risk' would herald a new era in the
      prevention, treatment and insights into pathogenesis of neoplasia. However, few
      would have predicted the accelerated pace of knowledge that ensued. The
      successive symposia that we held on this subject have given us a unique
      perspective on the extent of this progress. This supplement and the selected
      papers that have been assembled document accomplishments in genetics,
      epidemiology, early detection, treatment, preventive measures, as well as in the 
      ethical and psychosocial consequences enveloping families at risk. It also
      reveals how the convergence of the laboratory, the clinic and the public across
      two continents is able to ignite discovery and its applications.
FAU - Muggia, F
AU  - Muggia F
AD  - New York University Cancer Institute, New York 10016, USA.
      Franco.muggia@nyumc.org
FAU - Smaldone, V
AU  - Smaldone V
FAU - Paradiso, A
AU  - Paradiso A
LA  - eng
PT  - Journal Article
PL  - England
TA  - Ann Oncol
JT  - Annals of oncology : official journal of the European Society for Medical
      Oncology
JID - 9007735
SB  - IM
MH  - Breast Neoplasms/*genetics/*prevention & control
MH  - Female
MH  - Genes, BRCA1
MH  - Genes, BRCA2
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Ovarian Neoplasms/*genetics/*prevention & control
EDAT- 2011/02/10 06:00
MHDA- 2011/03/26 06:00
CRDT- 2011/02/03 06:00
PHST- 2011/02/03 06:00 [entrez]
PHST- 2011/02/10 06:00 [pubmed]
PHST- 2011/03/26 06:00 [medline]
AID - S0923-7534(19)38049-4 [pii]
AID - 10.1093/annonc/mdq669 [doi]
PST - ppublish
SO  - Ann Oncol. 2011 Jan;22 Suppl 1:i67-8. doi: 10.1093/annonc/mdq669.


PMID- 21285154
OWN - NLM
STAT- MEDLINE
DCOM- 20110325
LR  - 20200206
IS  - 1569-8041 (Electronic)
IS  - 0923-7534 (Linking)
VI  - 22 Suppl 1
DP  - 2011 Jan
TI  - Social and ethical implications of BRCA testing.
PG  - i60-6
LID - 10.1093/annonc/mdq668 [doi]
AB  - Oncologists are asked with increasing frequency to counsel their patients with
      respect to the medical, psychological and social repercussions of genetic testing
      for cancer susceptibility that may have been prescribed by physicians or carried 
      out through direct-to-consumer tests. This article critically reviews the main
      ethical and social implications of BRCA testing, focusing on genetic
      responsibility and genetic discrimination. Genetic responsibility toward oneself 
      and others is a highly debated implication of genetic testing for cancer
      predisposition that requires broad considerations of the boundaries between
      individual and community rights and a reappraisal of the notion of autonomy as
      relational. Physicians' duty to warn 'at risk' relatives can be an ethical
      quandary, yet confidentiality is key to the patient-doctor relationship. Mutation
      carriers may be subject to different forms and degrees of genetic discrimination 
      and many individuals at risk have forgone BRCA testing to avoid potential
      discrimination. The scientific and medical community, together with patients and 
      the public, has actively engaged against genetic discrimination. The legislation 
      in many countries now protects against genetic discrimination by insurance
      companies and employers. Legal and regulatory issues are not the final answer to 
      discrimination and profound cultural changes are required to create understanding
      and acceptance of all differences.
FAU - Surbone, A
AU  - Surbone A
AD  - Department of Medicine, Division of Medical Oncology, New York University Medical
      School, 550 First Avenue, BCD 556, New York, NY, USA. antonella.surbone@nyumc.org
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Ann Oncol
JT  - Annals of oncology : official journal of the European Society for Medical
      Oncology
JID - 9007735
SB  - IM
MH  - Breast Neoplasms/*genetics
MH  - European Union
MH  - Genes, BRCA1
MH  - Genes, BRCA2
MH  - Genetic Predisposition to Disease
MH  - Genetic Testing/*ethics/legislation & jurisprudence
MH  - Humans
MH  - *Prejudice
MH  - United States
EDAT- 2011/02/10 06:00
MHDA- 2011/03/26 06:00
CRDT- 2011/02/03 06:00
PHST- 2011/02/03 06:00 [entrez]
PHST- 2011/02/10 06:00 [pubmed]
PHST- 2011/03/26 06:00 [medline]
AID - S0923-7534(19)38048-2 [pii]
AID - 10.1093/annonc/mdq668 [doi]
PST - ppublish
SO  - Ann Oncol. 2011 Jan;22 Suppl 1:i60-6. doi: 10.1093/annonc/mdq668.


PMID- 21276325
OWN - NLM
STAT- MEDLINE
DCOM- 20110422
LR  - 20110131
IS  - 1815-7920 (Electronic)
IS  - 1027-3719 (Linking)
VI  - 15 Suppl 1
DP  - 2011 Jan
TI  - Guidelines for conducting tuberculin skin test surveys in high-prevalence
      countries.
PG  - S1-25
AB  - This Supplement provides an update on guidelines first published in 1996 on
      conducting a tuberculin skin test survey and analyzing the resulting data. The
      updated guidelines add experiences gained from community surveys, revisit the
      proposed sampling strategies, and provide additional information on ethical
      considerations.
FAU - Rieder, Hans L
AU  - Rieder HL
AD  - Department of Tuberculosis, International Union Against Tuberculosis and Lung
      Disease, Paris, France. TBRieder@tbrieder.org
FAU - Chadha, Vineet K
AU  - Chadha VK
FAU - Nagelkerke, Nico J D
AU  - Nagelkerke NJ
FAU - van Leth, Frank
AU  - van Leth F
FAU - van der Werf, Marieke J
AU  - van der Werf MJ
CN  - KNCV Tuberculosis Foundation
LA  - eng
PT  - Journal Article
PT  - Practice Guideline
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - Int J Tuberc Lung Dis
JT  - The international journal of tuberculosis and lung disease : the official journal
      of the International Union against Tuberculosis and Lung Disease
JID - 9706389
SB  - IM
MH  - *Endemic Diseases
MH  - Health Surveys/standards
MH  - Humans
MH  - Predictive Value of Tests
MH  - Prevalence
MH  - Reproducibility of Results
MH  - Tuberculin Test/*standards
MH  - Tuberculosis/diagnosis/epidemiology/microbiology
EDAT- 2011/02/10 06:00
MHDA- 2011/04/26 06:00
CRDT- 2011/02/01 06:00
PHST- 2011/02/01 06:00 [entrez]
PHST- 2011/02/10 06:00 [pubmed]
PHST- 2011/04/26 06:00 [medline]
PST - ppublish
SO  - Int J Tuberc Lung Dis. 2011 Jan;15 Suppl 1:S1-25.


PMID- 21301825
OWN - NLM
STAT- MEDLINE
DCOM- 20110727
LR  - 20211020
IS  - 1432-1041 (Electronic)
IS  - 0031-6970 (Linking)
VI  - 67 Suppl 1
DP  - 2011 May
TI  - Innovative study design for paediatric clinical trials.
PG  - 109-15
LID - 10.1007/s00228-011-0990-y [doi]
AB  - PURPOSE: Despite representing a fundamental step towards the efficacious and safe
      utilisation of drugs in the paediatric population, the conduct of clinical trials
      in children poses several problems. Methodological issues and ethical concerns
      represent the major obstacles that have traditionally limited paediatric
      research. The randomised clinical trial, mainstay of clinical studies to assess
      the effects of any therapeutic intervention, shows some weaknesses that make it
      scarcely applicable to the paediatric population. Alternative and innovative
      approaches to clinical trial design in small populations have been developed in
      the last few decades with the aim of overcoming the limits related to small
      samples and to the acceptability of the trial. METHODS: This systematic review
      describes a variety of alternative designs to assess efficacy and safety in the
      paediatric population, including their applicability, advantages, disadvantages
      and real case examples. Approaches include sequential and adaptive designs,
      Bayesian methods and other innovative approaches. RESULTS: By limiting the sample
      size and increasing acceptability, these methods may rationally limit the amount 
      of experimentation in children to what is achievable, necessary and ethical
      CONCLUSION: Thanks to their features, these methods represent a reliable way of
      ultimately improving paediatric care.
FAU - Baiardi, Paola
AU  - Baiardi P
AD  - Consorzio per Valutazioni Biologiche e Farmacologiche, Via Luigi Porta 14, Pavia,
      Italy. pbaiardi@cvbf.net
FAU - Giaquinto, Carlo
AU  - Giaquinto C
FAU - Girotto, Silvia
AU  - Girotto S
FAU - Manfredi, Cristina
AU  - Manfredi C
FAU - Ceci, Adriana
AU  - Ceci A
CN  - TEDDY Network of Excellence
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20110208
PL  - Germany
TA  - Eur J Clin Pharmacol
JT  - European journal of clinical pharmacology
JID - 1256165
SB  - IM
MH  - Bayes Theorem
MH  - Child
MH  - Humans
MH  - Pediatrics/*methods
MH  - Randomized Controlled Trials as Topic/*methods
MH  - Research Design
MH  - Therapies, Investigational/methods
EDAT- 2011/02/09 06:00
MHDA- 2011/07/28 06:00
CRDT- 2011/02/09 06:00
PHST- 2010/12/31 00:00 [received]
PHST- 2011/01/03 00:00 [accepted]
PHST- 2011/02/09 06:00 [entrez]
PHST- 2011/02/09 06:00 [pubmed]
PHST- 2011/07/28 06:00 [medline]
AID - 10.1007/s00228-011-0990-y [doi]
PST - ppublish
SO  - Eur J Clin Pharmacol. 2011 May;67 Suppl 1:109-15. doi: 10.1007/s00228-011-0990-y.
      Epub 2011 Feb 8.


PMID- 21300949
OWN - NLM
STAT- MEDLINE
DCOM- 20110322
LR  - 20211020
IS  - 1538-3636 (Electronic)
IS  - 0003-990X (Linking)
VI  - 68
IP  - 2
DP  - 2011 Feb
TI  - Preservation of the capacity to appoint a proxy decision maker: implications for 
      dementia research.
PG  - 214-20
LID - 10.1001/archgenpsychiatry.2010.191 [doi]
AB  - CONTEXT: Research involving persons with impaired decision-making capacity (such 
      as persons with Alzheimer disease [AD]) remains ethically challenging, especially
      when the research involves significant risk. If individuals incapable of
      consenting to research studies were able to appoint a research proxy, it would
      allow for an appointed surrogate (rather than a de facto surrogate) to represent 
      the subject. OBJECTIVE: To assess the extent to which persons with AD retain
      their capacity to appoint a research proxy. DESIGN: Interview study. SETTING:
      Academic research. PARTICIPANTS: One hundred eighty-eight persons with AD were
      interviewed for their capacity to appoint a proxy for research and to provide
      consent to 2 hypothetical research scenarios, a lower-risk randomized clinical
      trial testing a new drug (drug RCT) and a higher-risk randomized clinical trial
      testing neurosurgical cell implants using a sham control condition (neurosurgical
      RCT). Categorical capacity status for each subject was determined by independent 
      videotaped reviews of capacity interviews by 5 experienced psychiatrists. MAIN
      OUTCOME MEASURES: Categorical capacity determinations for the capacity to appoint
      a research proxy, capacity to consent to a drug RCT, and capacity to consent to a
      neurosurgical RCT. RESULTS: Data showed that 37.7% (40 of 106) of those deemed
      incapable of consenting to the drug RCT and 54.8% (86 of 157) of those deemed
      incapable of consenting to the neurosurgical RCT were found capable of appointing
      a research proxy. Only 7 of 186 (3.8%) were deemed capable of consenting to the
      neurosurgical RCT by all 5 psychiatrists. CONCLUSIONS: A substantial proportion
      of persons with AD who were thought incapable of consenting to lower-risk or
      higher-risk studies have preserved capacity for appointing a research proxy.
      Because few persons are found to be unequivocally capable of providing
      independent consent to higher-risk AD research, providing for an appointed
      surrogate even after the onset of AD, which might best be done in the early
      stages of the illness, may help address key ethical challenges to AD research.
FAU - Kim, Scott Y H
AU  - Kim SY
AD  - Center Bioethics and Social Sciences in Medicine, and Department of Psychiatry,
      University of Michigan, 300 N Ingalls St, 7C27, Ann Arbor, MI 48109, USA.
      scottkim@umich.edu
FAU - Karlawish, Jason H
AU  - Karlawish JH
FAU - Kim, H Myra
AU  - Kim HM
FAU - Wall, Ian F
AU  - Wall IF
FAU - Bozoki, Andrea C
AU  - Bozoki AC
FAU - Appelbaum, Paul S
AU  - Appelbaum PS
LA  - eng
GR  - R01 MH075023/MH/NIMH NIH HHS/United States
GR  - R01-MH075023/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Arch Gen Psychiatry
JT  - Archives of general psychiatry
JID - 0372435
RN  - 0 (Nootropic Agents)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/diagnosis/*psychology
MH  - Comprehension
MH  - Decision Making/*ethics
MH  - Ethics, Research
MH  - Female
MH  - Humans
MH  - Informed Consent/ethics/legislation & jurisprudence
MH  - Male
MH  - Mental Competency/*legislation & jurisprudence/psychology
MH  - Mental Status Schedule/statistics & numerical data
MH  - Neurosurgical Procedures/legislation & jurisprudence
MH  - Nootropic Agents/therapeutic use
MH  - Observer Variation
MH  - Patient Selection/*ethics
MH  - Proxy/*legislation & jurisprudence/psychology
MH  - Psychometrics
MH  - Randomized Controlled Trials as Topic/legislation & jurisprudence
PMC - PMC3349937
MID - NIHMS374025
EDAT- 2011/02/09 06:00
MHDA- 2011/03/23 06:00
CRDT- 2011/02/09 06:00
PHST- 2011/02/09 06:00 [entrez]
PHST- 2011/02/09 06:00 [pubmed]
PHST- 2011/03/23 06:00 [medline]
AID - 68/2/214 [pii]
AID - 10.1001/archgenpsychiatry.2010.191 [doi]
PST - ppublish
SO  - Arch Gen Psychiatry. 2011 Feb;68(2):214-20. doi:
      10.1001/archgenpsychiatry.2010.191.


PMID- 21300720
OWN - NLM
STAT- MEDLINE
DCOM- 20110307
LR  - 20181023
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 342
DP  - 2011 Feb 7
TI  - Researcher didn't get ethical approval for 68 studies, investigators say.
PG  - d833
LID - 10.1136/bmj.d833 [doi]
LID - bmj.d833 [pii]
FAU - Dyer, Clare
AU  - Dyer C
LA  - eng
PT  - Comment
PT  - News
DEP - 20110207
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
SB  - IM
CON - BMJ. 2010;341:c7026. PMID: 21139008
MH  - Anesthesiology/*ethics
MH  - Germany
MH  - Humans
MH  - *Publishing
MH  - Retraction of Publication as Topic
MH  - Scientific Misconduct/*ethics
EDAT- 2011/02/09 06:00
MHDA- 2011/03/08 06:00
CRDT- 2011/02/09 06:00
PHST- 2011/02/09 06:00 [entrez]
PHST- 2011/02/09 06:00 [pubmed]
PHST- 2011/03/08 06:00 [medline]
AID - 10.1136/bmj.d833 [doi]
PST - epublish
SO  - BMJ. 2011 Feb 7;342:d833. doi: 10.1136/bmj.d833.


PMID- 21300494
OWN - NLM
STAT- MEDLINE
DCOM- 20120319
LR  - 20181201
IS  - 1872-7727 (Electronic)
IS  - 0720-048X (Linking)
VI  - 80
IP  - 3
DP  - 2011 Dec
TI  - Clinic application of Epub of medical imaging film in CT workflow.
PG  - e552-6
LID - 10.1016/j.ejrad.2011.01.034 [doi]
AB  - OBJECTIVE: To investigate the clinical effects of the Epub of medical imaging
      film (EMIF) in CT workflow. METHODS: All experiments were approved by the ethics 
      committee of the local district. An EMIF application is fully implemented in PACS
      according to the DICOM 3.0 standard. For a statistical comparison in the effects 
      of the EMIF in CT workflow, consecutive 50,000 CT hardcopy film prints have been 
      randomly selected before and after the EMIF application in PACS, respectively.
      The role of the EMIF in the application of hardcopy films, the clinic practice,
      the integrality of the quality control data archived in PACS/RIS and so on is
      investigated. RESULTS: For consecutive 50,000 CT hardcopy films before vs. after 
      the EMIF application respectively, the counts of wasted films are 21 vs. 14
      sheets due to the hardware problem, 28 vs. 0 sheets owing to operation errors,
      and 24 vs. 0 sheets caused by serious defects in image layout. Reissuing films
      for lost films and other special needs is 60 vs. 55 sheets. The average reissuing
      film time for each case is 16.97+/-6.14 vs. 4.36+/-1.26 min (t=5.94, p<0.01). The
      EMIF application has offered more convenience for medical viewing and reviewing, 
      and has enhanced the integrality of the quality control data archived in PACS/RIS
      (chi2=320.835, P<0.01). CONCLUSION: EMIF application in clinical healthcare can
      help enhance the function of PACS/RIS, and improve the quality and efficiency in 
      CT routine work.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Fan, Shu-Feng
AU  - Fan SF
AD  - Radiology Department, Zhongda Hospital affiliated to Southeast University,
      Nanjing, 210009, PR China. shufengfan@163.com
FAU - Yi, Zhang
AU  - Yi Z
FAU - Xu, Zhe
AU  - Xu Z
FAU - Ding, Jian-Rong
AU  - Ding JR
FAU - Zhu, Hua-Yong
AU  - Zhu HY
FAU - Huang, Jin-Biao
AU  - Huang JB
FAU - Teng, Gao-Jun
AU  - Teng GJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110205
PL  - Ireland
TA  - Eur J Radiol
JT  - European journal of radiology
JID - 8106411
SB  - IM
MH  - China
MH  - Radiology Information Systems
MH  - Tomography, X-Ray Computed/*statistics & numerical data
MH  - *Utilization Review
MH  - Workflow
MH  - X-Ray Film/*statistics & numerical data
EDAT- 2011/02/09 06:00
MHDA- 2012/03/20 06:00
CRDT- 2011/02/09 06:00
PHST- 2010/12/05 00:00 [received]
PHST- 2011/01/04 00:00 [accepted]
PHST- 2011/02/09 06:00 [entrez]
PHST- 2011/02/09 06:00 [pubmed]
PHST- 2012/03/20 06:00 [medline]
AID - S0720-048X(11)00063-5 [pii]
AID - 10.1016/j.ejrad.2011.01.034 [doi]
PST - ppublish
SO  - Eur J Radiol. 2011 Dec;80(3):e552-6. doi: 10.1016/j.ejrad.2011.01.034. Epub 2011 
      Feb 5.


PMID- 21300346
OWN - NLM
STAT- MEDLINE
DCOM- 20110621
LR  - 20121115
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 95
IP  - 6
DP  - 2011 May
TI  - One patient, two uteri, two endometrial ablations: case report of thermal balloon
      ablation in uterine didelphys.
PG  - 2123.e5-7
LID - 10.1016/j.fertnstert.2011.01.037 [doi]
AB  - OBJECTIVE: To describe the clinical application and outcomes after endometrial
      ablation with ThermachoiceIII (Ethicon, Somerville, NJ) in a patient with uterine
      didelphys with heavy menstrual bleeding. DESIGN: Case report. SETTING: Inner-city
      community obstetrics and gynecology clinic. PATIENT(S): A 44-year-old Hispanic
      woman, gravida 3, para 0, with three spontaneous abortions. INTERVENTION(S): The 
      patient underwent diagnostic hysteroscopy, gynecologic dilation and curettage,
      and endometrial ablation with ThermachoiceIII. MAIN OUTCOME MEASURE(S): Menstrual
      pattern at 3 months postoperatively, as either amenorrhea (complete lack of
      menstrual flow), hypomenorrhea (scant or minimal flow lasting <5 days, requiring 
      only light pads), or failure (flow similar to pretreatment state or requiring any
      other therapy), as well as dysmenorrhea reduction from baseline. Hemoglobin value
      at 3 months was compared with baseline. RESULT(S): At 3 months, hypomenorrhea was
      maintained. Bleeding days were 10 per month at baseline and 2 per month after
      therapy. Visual analogue scale score for dysmenorrhea was 8 at baseline and 2
      (mean) at study end. Hemoglobin was 8.9 g/dL at baseline (preoperatively) and
      11.1 g/dL at 3 months postoperatively. CONCLUSION(S): Successful conservative
      therapy of menorrhagia seems possible with thermal balloon ablation in a uterine 
      didelphic patient.
CI  - Copyright (c) 2011 American Society for Reproductive Medicine. Published by
      Elsevier Inc. All rights reserved.
FAU - Chapa, Hector O
AU  - Chapa HO
AD  - Women's Specialty Center Dallas, Dallas, Texas 75208, USA. ChapaMD@gmail.com
FAU - Venegas, Gonzalo
AU  - Venegas G
FAU - Antonetti, Alfred G
AU  - Antonetti AG
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20110205
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
SB  - IM
MH  - Abortion, Habitual/surgery/therapy
MH  - Adult
MH  - Catheterization/methods
MH  - Endometrial Ablation Techniques/*methods
MH  - Female
MH  - Humans
MH  - Pregnancy
MH  - Uterus/*abnormalities/*surgery
EDAT- 2011/02/09 06:00
MHDA- 2011/06/22 06:00
CRDT- 2011/02/09 06:00
PHST- 2010/11/08 00:00 [received]
PHST- 2011/01/05 00:00 [revised]
PHST- 2011/01/07 00:00 [accepted]
PHST- 2011/02/09 06:00 [entrez]
PHST- 2011/02/09 06:00 [pubmed]
PHST- 2011/06/22 06:00 [medline]
AID - S0015-0282(11)00047-1 [pii]
AID - 10.1016/j.fertnstert.2011.01.037 [doi]
PST - ppublish
SO  - Fertil Steril. 2011 May;95(6):2123.e5-7. doi: 10.1016/j.fertnstert.2011.01.037.
      Epub 2011 Feb 5.


PMID- 21300312
OWN - NLM
STAT- MEDLINE
DCOM- 20110809
LR  - 20110208
IS  - 1879-2499 (Electronic)
IS  - 1369-8486 (Linking)
VI  - 42
IP  - 1
DP  - 2011 Mar
TI  - Ethics in Darwin's melancholy vision.
PG  - 20-9
LID - 10.1016/j.shpsc.2010.11.004 [doi]
AB  - Darwinian natural selection draws on Malthus' harsh vision of human society to
      explain how organisms come to be adapted to their environments. Natural selection
      produces the appearance of teleology, but requires only efficient causal
      processes: undirected, heritable variation combined with effects of the
      variations on survival and reproduction. This paper draws a sharp distinction
      between the resulting form of backwards-directed teleology and the
      future-directed teleology we ascribe to intentional human activity. Rather than
      dismiss teleology as mere illusion, the paper concludes with an account of how
      future-directed teleology came to be a justifiable part of how we understand
      ourselves.
CI  - Copyright (c) 2011. Published by Elsevier Ltd.
FAU - Brown, Bryson
AU  - Brown B
AD  - University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada.
      brown@uleth.ca
LA  - eng
PT  - Journal Article
DEP - 20110126
PL  - England
TA  - Stud Hist Philos Biol Biomed Sci
JT  - Studies in history and philosophy of biological and biomedical sciences
JID - 9810965
SB  - IM
MH  - *Adaptation, Biological
MH  - Animals
MH  - *Ethical Theory
MH  - *Genetic Fitness
MH  - Genetic Variation
MH  - Humans
MH  - Reproduction
MH  - *Selection, Genetic
EDAT- 2011/02/09 06:00
MHDA- 2011/08/10 06:00
CRDT- 2011/02/09 06:00
PHST- 2011/02/09 06:00 [entrez]
PHST- 2011/02/09 06:00 [pubmed]
PHST- 2011/08/10 06:00 [medline]
AID - S1369-8486(10)00097-X [pii]
AID - 10.1016/j.shpsc.2010.11.004 [doi]
PST - ppublish
SO  - Stud Hist Philos Biol Biomed Sci. 2011 Mar;42(1):20-9. doi:
      10.1016/j.shpsc.2010.11.004. Epub 2011 Jan 26.


PMID- 21300179
OWN - NLM
STAT- MEDLINE
DCOM- 20110830
LR  - 20220317
IS  - 1559-2030 (Electronic)
IS  - 1551-7144 (Linking)
VI  - 32
IP  - 3
DP  - 2011 May
TI  - Data withdrawal in randomized controlled trials: Defining the problem and
      proposing solutions: a commentary.
PG  - 318-22
LID - 10.1016/j.cct.2011.01.016 [doi]
AB  - It is not uncommon for a participant to withdraw from a randomized controlled
      trial (RCT). The withdrawal of a participant results in missing data and the
      potential for withdrawal bias. Data withdrawal, or a request from a participant
      to withdraw all of their previously collected data from a study, is particularly 
      problematic because it leaves little opportunity to characterize or statistically
      address those that have withdrawn to minimize withdrawal bias. The aim of this
      commentary is to (1) provide a synthesis of available information on the ethical 
      and methodological issues related to data withdrawal in RCTs and (2) provide some
      suggestions on how to minimize the impact of data withdrawal during the execution
      or analysis phases of an RCT. We searched PubMed, EMBASE and JSTOR for published 
      articles on data withdrawal. In addition, we used internet sources as an
      additional tool to identify content on data withdrawal from research ethics
      guidelines, legislation, research ethics boards, funding agencies, professional
      organizations and researchers. We did not find any definitive guidelines for
      dealing with data withdrawal. We propose recommendations for minimizing the
      occurrence of data withdrawal, including explicit and clear descriptions in
      consent forms of how data will be handled after participant withdrawal. We also
      suggest using imputation techniques to deal with the missing data during
      analysis. The current commentary can be used to minimize the impact of data
      withdrawal in RCTs.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Ye, Chenglin
AU  - Ye C
AD  - Department of Mathematics and Statistics, McMaster University, Hamilton, Ontario,
      Canada; Department of Clinical Epidemiology and Biostatistics, McMaster
      University, Hamilton, Ontario, Canada; Biostatistics Unit, St Joseph's Healthcare
      Hamilton, Hamilton, Ontario, Canada.
FAU - Giangregorio, Lora
AU  - Giangregorio L
FAU - Holbrook, Anne
AU  - Holbrook A
FAU - Pullenayegum, Eleanor
AU  - Pullenayegum E
FAU - Goldsmith, Charlie H
AU  - Goldsmith CH
FAU - Thabane, Lehana
AU  - Thabane L
LA  - eng
PT  - Editorial
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110204
PL  - United States
TA  - Contemp Clin Trials
JT  - Contemporary clinical trials
JID - 101242342
SB  - IM
MH  - Humans
MH  - Patient Preference
MH  - *Practice Guidelines as Topic
MH  - Randomized Controlled Trials as Topic/*ethics/*methods
MH  - Research Design/*standards
EDAT- 2011/02/09 06:00
MHDA- 2011/08/31 06:00
CRDT- 2011/02/09 06:00
PHST- 2010/11/25 00:00 [received]
PHST- 2011/01/23 00:00 [revised]
PHST- 2011/01/31 00:00 [accepted]
PHST- 2011/02/09 06:00 [entrez]
PHST- 2011/02/09 06:00 [pubmed]
PHST- 2011/08/31 06:00 [medline]
AID - S1551-7144(11)00043-7 [pii]
AID - 10.1016/j.cct.2011.01.016 [doi]
PST - ppublish
SO  - Contemp Clin Trials. 2011 May;32(3):318-22. doi: 10.1016/j.cct.2011.01.016. Epub 
      2011 Feb 4.


PMID- 21299969
OWN - NLM
STAT- MEDLINE
DCOM- 20110421
LR  - 20151119
IS  - 0767-0974 (Print)
IS  - 0767-0974 (Linking)
VI  - 27
IP  - 1
DP  - 2011 Jan
TI  - [Direct-to-consumer genetic testing through Internet: marketing, ethical and
      social issues].
PG  - 95-102
LID - 10.1051/medsci/201127195 [doi]
AB  - We probably did not anticipate all the consequences of the direct to consumer
      genetic tests on Internet, resulting from the combined skills of communication
      and genomic advances. What are the commercial strategies used by the companies
      offering direct-to-consumer genetic tests on Internet and what are the different 
      social expectations on which they focus? Through a quantitative and qualitative
      analysis of the web sites offering such tests, it seems that these companies
      target a triple market based on: the "healthism" which raises health and hygiene 
      to the top of the social values; the contemporary demands of the users to become 
      actual actors of health decisions; and finally on the need for bio-social
      relationships. These three commercial strategies underlie various ethical and
      societal issues justifying a general analysis.
FAU - Ducournau, Pascal
AU  - Ducournau P
AD  - Inserm U558, Epidemiologie et Analyses en Sante Publique, Risques, Maladies
      Chroniques, Handicaps, CUFR J.F. Champollion, Albi, France. ducourna@cict.fr
FAU - Gourraud, Pierre-Antoine
AU  - Gourraud PA
FAU - Rial-Sebbag, Emmanuelle
AU  - Rial-Sebbag E
FAU - Bulle, Alexandre
AU  - Bulle A
FAU - Cambon-Thomsen, Anne
AU  - Cambon-Thomsen A
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
TT  - Tests genetiques en acces libre sur Internet: strategies commerciales et enjeux
      ethiques et societaux.
PL  - France
TA  - Med Sci (Paris)
JT  - Medecine sciences : M/S
JID - 8710980
SB  - IM
CIN - Med Sci (Paris). 2012 Mar;28(3):325-8. PMID: 22480659
MH  - *Access to Information/ethics/legislation & jurisprudence/psychology
MH  - Attitude to Health
MH  - European Union
MH  - France
MH  - Genetic Counseling
MH  - Genetic Diseases, Inborn/diagnosis/epidemiology/genetics/psychology
MH  - Genetic Privacy
MH  - *Genetic Testing/ethics/legislation & jurisprudence/supply & distribution
MH  - Humans
MH  - *Internet/ethics/legislation & jurisprudence
MH  - Marketing/ethics/legislation & jurisprudence/methods
MH  - Patient Education as Topic
MH  - Patient Participation
MH  - Personal Autonomy
MH  - Precision Medicine
MH  - Risk
MH  - *Self Care/ethics/psychology/trends
MH  - Social Values
EDAT- 2011/02/09 06:00
MHDA- 2011/04/22 06:00
CRDT- 2011/02/09 06:00
PHST- 2011/02/09 06:00 [entrez]
PHST- 2011/02/09 06:00 [pubmed]
PHST- 2011/04/22 06:00 [medline]
AID - 00/00/10/4B/ [pii]
AID - 10.1051/medsci/201127195 [doi]
PST - ppublish
SO  - Med Sci (Paris). 2011 Jan;27(1):95-102. doi: 10.1051/medsci/201127195.


PMID- 21299756
OWN - NLM
STAT- MEDLINE
DCOM- 20110624
LR  - 20110208
IS  - 1478-5153 (Electronic)
IS  - 1362-1017 (Linking)
VI  - 16
IP  - 2
DP  - 2011 Mar-Apr
TI  - A model to support the ethical elements of decisions made by advanced level
      practitioners.
PG  - 53-4
LID - 10.1111/j.1478-5153.2011.00445.x [doi]
FAU - Hurley, Ciaran
AU  - Hurley C
LA  - eng
PT  - Editorial
PL  - England
TA  - Nurs Crit Care
JT  - Nursing in critical care
JID - 9808649
MH  - Critical Care/*ethics/standards
MH  - Critical Illness/nursing
MH  - *Decision Support Techniques
MH  - Evidence-Based Medicine/ethics
MH  - Female
MH  - Humans
MH  - Male
MH  - Models, Nursing
MH  - Nurse Practitioners/*ethics/standards
MH  - Nursing Assessment/*ethics/standards
MH  - Nursing Process
EDAT- 2011/02/09 06:00
MHDA- 2011/06/28 06:00
CRDT- 2011/02/09 06:00
PHST- 2011/02/09 06:00 [entrez]
PHST- 2011/02/09 06:00 [pubmed]
PHST- 2011/06/28 06:00 [medline]
AID - 10.1111/j.1478-5153.2011.00445.x [doi]
PST - ppublish
SO  - Nurs Crit Care. 2011 Mar-Apr;16(2):53-4. doi: 10.1111/j.1478-5153.2011.00445.x.


PMID- 21299476
OWN - NLM
STAT- MEDLINE
DCOM- 20110524
LR  - 20151119
IS  - 1541-2563 (Electronic)
IS  - 1541-2563 (Linking)
VI  - 8
IP  - 1
DP  - 2011 Feb
TI  - Informed consent process in Alpha-1 testing of at-risk children: views of parents
      and adults tested as children.
PG  - 30-8
LID - 10.3109/15412555.2010.541958 [doi]
AB  - Targeted testing programs are identifying increasing numbers of adults affected
      by Alpha-1 Antitrypsin Deficiency (Alpha-1) who are making decisions about
      genetic testing for their at-risk children. Although there are possible benefits,
      there are also potential risks. The purpose of this pilot study was to explore
      attitudes toward testing at-risk children from the first hand perspective of
      those involved, identify the benefits and risks experienced therein, and compare 
      the views of parents and adults tested as children (ATC). The results of this
      pilot study suggest that ATC were significantly more favorable to including
      children in testing decisions than parents. ATC strongly indicated that they want
      to be involved in the testing decision and give permission prior to testing (p = 
      0.007). While the majority of ATC and parents were in favor of newborn screening 
      for Alpha-1, parents had more extreme views, both positive and negative (p =
      0.04). Both ATC and parents expressed significantly higher likelihoods of
      possible risks and benefits following Alpha-1 testing than they actually
      experienced. Results do not reveal serious harms from testing at-risk children.
      The two groups indicated that they want information regarding access to
      insurance, inheritance and expression, impact on anxiety, association with
      smoking, and usefulness in future planning prior to a decision to test or not to 
      test at risk children. From the resulting data and ethical analysis we recommend 
      that parents and children have relevant information prior to testing for Alpha-1 
      and that at risk children are directly involved in the decision-making process
      prior to testing.
FAU - Coors, Marilyn E
AU  - Coors ME
AD  - Center for Bioethics & Humanities, University of Colorado Denver, Aurora,
      Colorado 80045, USA. marilyn.coors@ucdenver.edu
FAU - Moseley, Ray
AU  - Moseley R
FAU - McGorray, Susan
AU  - McGorray S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - COPD
JT  - COPD
JID - 101211769
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Advisory Committees
MH  - Child
MH  - Decision Making
MH  - Early Diagnosis
MH  - Female
MH  - Focus Groups
MH  - Genetic Testing/*psychology
MH  - Health Literacy
MH  - Humans
MH  - Infant, Newborn
MH  - Informed Consent/*psychology
MH  - Male
MH  - Neonatal Screening/psychology
MH  - Parents
MH  - Patient Acceptance of Health Care/*psychology
MH  - Pilot Projects
MH  - Risk Assessment
MH  - Surveys and Questionnaires
MH  - Young Adult
MH  - alpha 1-Antitrypsin Deficiency/*diagnosis
EDAT- 2011/02/09 06:00
MHDA- 2011/05/25 06:00
CRDT- 2011/02/09 06:00
PHST- 2011/02/09 06:00 [entrez]
PHST- 2011/02/09 06:00 [pubmed]
PHST- 2011/05/25 06:00 [medline]
AID - 10.3109/15412555.2010.541958 [doi]
PST - ppublish
SO  - COPD. 2011 Feb;8(1):30-8. doi: 10.3109/15412555.2010.541958.


PMID- 21298403
OWN - NLM
STAT- MEDLINE
DCOM- 20111027
LR  - 20211020
IS  - 1572-8633 (Electronic)
IS  - 1386-7423 (Linking)
VI  - 14
IP  - 3
DP  - 2011 Aug
TI  - Evidence and the end of medicine.
PG  - 273-80
LID - 10.1007/s11019-011-9314-3 [doi]
AB  - Fifty years ago, in 1961, Feinstein published his first path-breaking articles
      leading to his seminal work Clinical Judgement and to the establishment of
      clinical epidemiology. Feinstein had an Aristotelian approach to scientific
      method: methods must be adapted to the material examined. Feinstein died 10 years
      ago and few years before his death he concluded that efforts to promote a
      person-oriented medicine had failed. He criticised medicine for not having
      recognized that only persons can suitably observe, evaluate and rate their own
      health status. Feinstein's position was-as in Clinical Judgement-methodological. 
      He didn't espouse ethical principles. He pointed to methodological deficiencies
      in clinical epidemiology and evidence-based medicine. In this article we'll
      provide a framework for understanding and justifying Feinstein's call for a
      person-oriented medicine which recognizes patients as co-actors in clinical
      reasoning. It's argued that craftsmanship and practical wisdom are integrated in 
      clinical judgement and reasoning and that clinical reasoning is not only about
      means to achieve the end, health. We do also reason and deliberate about ends.
      The 'defining end' of medicine (health) has continuously been negotiated and so
      been the object of deliberation. For centuries among professionals, in recent
      years among professionals and patients. These negotiations and deliberations lead
      to ongoing specifications of health as a 'guiding end', i.e. an end guiding
      clinical reasoning about what to do in particular situations. Feinstein's
      self-critical account to clinical epidemiology at the end of his professional
      career reflects the fact that patients during the last 30-40 years (i.e. in the
      period after the publication of Clinical Judgement) widely have been recognized
      as persons with rights to autonomy. Feinstein's lesson is, however, that
      espousing and recognizing ethical ideals is not enough. A change of clinical
      practice and its methods is necessary. His critique also implies that clinical
      epidemiology and evidence-based medicine as practiced haven't provided such a
      turn.
FAU - Thorgaard, Keld
AU  - Thorgaard K
AD  - Health, Humanity and Culture, Institute of Philosophy and History of Ideas,
      Aarhus University, Denmark. filkt@hum.au.dk
FAU - Jensen, Uffe Juul
AU  - Jensen UJ
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Med Health Care Philos
JT  - Medicine, health care, and philosophy
JID - 9815900
SB  - IM
MH  - Ethics
MH  - Evidence-Based Medicine/*ethics/organization & administration
MH  - Humans
MH  - *Judgment
MH  - Patient-Centered Care/*ethics/organization & administration
MH  - Philosophy, Medical
EDAT- 2011/02/08 06:00
MHDA- 2011/10/28 06:00
CRDT- 2011/02/08 06:00
PHST- 2011/02/08 06:00 [entrez]
PHST- 2011/02/08 06:00 [pubmed]
PHST- 2011/10/28 06:00 [medline]
AID - 10.1007/s11019-011-9314-3 [doi]
PST - ppublish
SO  - Med Health Care Philos. 2011 Aug;14(3):273-80. doi: 10.1007/s11019-011-9314-3.


PMID- 21298346
OWN - NLM
STAT- MEDLINE
DCOM- 20110816
LR  - 20211020
IS  - 1573-0980 (Electronic)
IS  - 1386-7415 (Linking)
VI  - 32
IP  - 3
DP  - 2011 Jun
TI  - Dispelling a few false-positives: a reply to MacGregor and McNamee on doping.
PG  - 195-200
LID - 10.1007/s11017-011-9173-1 [doi]
AB  - McGregor and MacNamee recently, in this journal, offered several criticisms of an
      earlier article in which I attempted to refute a number of arguments for the
      claim that doping in sports is morally wrong. Their criticisms are numerous, but 
      focus on four domains. First, they sketch a view on which the risk profiles of
      different sports may make doping permissible in some and impermissible in others.
      Second, they suggest that my criticisms of safety-based arguments assume that
      doping opponents are bent on harm elimination, rather than harm management.
      Finally, they offer two methodological criticisms, the first pertaining to my use
      of analogical arguments, and the second pertaining to the general difficulties of
      making revisionist arguments in ethics. I defend my criticisms of safety-based
      arguments by showing that these do not rest on the assumptions McGregor and
      MacNamee attribute to me and by noting that their own view about the variable
      relevance of safety considerations is underdeveloped. As for their methodological
      arguments, I endeavor to show that these are misplaced, in that they either rest 
      on misinterpretations of my earlier article or on an excessively high standard
      for ethical argumentation.
FAU - Kious, Brent Michael
AU  - Kious BM
AD  - UCLA Medical Scientist Training Program, The David Geffen School of Medicine at
      UCLA, 23-385 Center for the Health Sciences, Box 957041/MC:704117, Los Angeles,
      CA 90095-7041, USA. bkious@mednet.ucla.edu
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Theor Med Bioeth
JT  - Theoretical medicine and bioethics
JID - 9805378
SB  - IM
MH  - Choice Behavior/*ethics
MH  - Coercion
MH  - Doping in Sports/*ethics
MH  - Ethical Analysis
MH  - Humans
MH  - *Morals
MH  - Psychomotor Performance/*drug effects/ethics
MH  - Risk
MH  - Safety
MH  - Sports/*ethics
PMC - PMC3090578
EDAT- 2011/02/08 06:00
MHDA- 2011/08/17 06:00
CRDT- 2011/02/08 06:00
PHST- 2011/02/08 06:00 [entrez]
PHST- 2011/02/08 06:00 [pubmed]
PHST- 2011/08/17 06:00 [medline]
AID - 10.1007/s11017-011-9173-1 [doi]
PST - ppublish
SO  - Theor Med Bioeth. 2011 Jun;32(3):195-200. doi: 10.1007/s11017-011-9173-1.


PMID- 21298069
OWN - NLM
STAT- MEDLINE
DCOM- 20110802
LR  - 20211020
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 6
IP  - 1
DP  - 2011 Jan 26
TI  - A modified vaccinia Ankara virus (MVA) vaccine expressing African horse sickness 
      virus (AHSV) VP2 protects against AHSV challenge in an IFNAR -/- mouse model.
PG  - e16503
LID - 10.1371/journal.pone.0016503 [doi]
AB  - African horse sickness (AHS) is a lethal viral disease of equids, which is
      transmitted by Culicoides midges that become infected after biting a viraemic
      host. The use of live attenuated vaccines has been vital for the control of this 
      disease in endemic regions. However, there are safety concerns over their use in 
      non-endemic countries. Research efforts over the last two decades have therefore 
      focused on developing alternative vaccines based on recombinant baculovirus or
      live viral vectors expressing structural components of the AHS virion. However,
      ethical and financial considerations, relating to the use of infected horses in
      high biosecurity installations, have made progress very slow. We have therefore
      assessed the potential of an experimental mouse-model for AHSV infection for
      vaccine and immunology research. We initially characterised AHSV infection in
      this model, then tested the protective efficacy of a recombinant vaccine based on
      modified vaccinia Ankara expressing AHS-4 VP2 (MVA-VP2).
FAU - Castillo-Olivares, Javier
AU  - Castillo-Olivares J
AD  - Institute for Animal Health, Pirbright, Woking, Surrey, United Kingdom.
      javier.castillo-olivares@bbsrc.ac.uk
FAU - Calvo-Pinilla, Eva
AU  - Calvo-Pinilla E
FAU - Casanova, Isabel
AU  - Casanova I
FAU - Bachanek-Bankowska, Katarzyna
AU  - Bachanek-Bankowska K
FAU - Chiam, Rachael
AU  - Chiam R
FAU - Maan, Sushila
AU  - Maan S
FAU - Nieto, Jose Maria
AU  - Nieto JM
FAU - Ortego, Javier
AU  - Ortego J
FAU - Mertens, Peter Paul Clement
AU  - Mertens PP
LA  - eng
GR  - BBS/B/00654/BB_/Biotechnology and Biological Sciences Research Council/United
      Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110126
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Capsid Proteins)
RN  - 0 (Ifnar1 protein, mouse)
RN  - 0 (VP2 protein, African horse sickness virus)
RN  - 0 (Vaccines, Synthetic)
RN  - 156986-95-7 (Receptor, Interferon alpha-beta)
SB  - IM
MH  - African Horse Sickness/*prevention & control/therapy
MH  - African Horse Sickness Virus/*genetics/immunology
MH  - Animals
MH  - Capsid Proteins/genetics/*therapeutic use
MH  - Disease Models, Animal
MH  - Genetic Vectors/*therapeutic use
MH  - Horses
MH  - Mice
MH  - Receptor, Interferon alpha-beta/deficiency/*genetics
MH  - Vaccines, Synthetic
MH  - Vaccinia virus/*genetics
PMC - PMC3027694
EDAT- 2011/02/08 06:00
MHDA- 2011/08/04 06:00
CRDT- 2011/02/08 06:00
PHST- 2010/08/24 00:00 [received]
PHST- 2011/01/03 00:00 [accepted]
PHST- 2011/02/08 06:00 [entrez]
PHST- 2011/02/08 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
AID - 10.1371/journal.pone.0016503 [doi]
PST - epublish
SO  - PLoS One. 2011 Jan 26;6(1):e16503. doi: 10.1371/journal.pone.0016503.


PMID- 21297458
OWN - NLM
STAT- MEDLINE
DCOM- 20110729
LR  - 20220409
IS  - 1530-0293 (Electronic)
IS  - 0090-3493 (Linking)
VI  - 39
IP  - 4
DP  - 2011 Apr
TI  - Critical care in resource-poor settings: lessons learned and future directions.
PG  - 860-7
LID - 10.1097/CCM.0b013e318206d6d5 [doi]
AB  - CONTEXT: Critical care faces the same challenges as other aspects of healthcare
      in the developing world. However, critical care faces an additional challenge in 
      that it has often been deemed too costly or complicated for resource-poor
      settings. This lack of prioritization is not justified. Hospital care for the
      sickest patients affects overall mortality, and public health interventions
      depend on community confidence in healthcare to ensure participation and
      adherence. Some of the most effective critical care interventions, including
      rapid fluid resuscitation, early antibiotics, and patient monitoring, are
      relatively inexpensive. Although cost-effectiveness studies on critical care in
      resource-poor settings have not been done, evidence from the surgical literature 
      suggests that even resource-intensive interventions can be cost effective in
      comparison to immunizations and human immunodeficiency virus care. In the
      developing world, where many critically ill patients are younger and have fewer
      comorbidities, critical care presents a remarkable opportunity to provide
      significant incremental benefit, arguably much more so than in the developed
      world. ESSENTIAL CONSIDERATIONS: Key areas of consideration in developing
      critical care in resource-poor settings include: Personnel and training,
      equipment and support services, ethics, and research. Strategies for training and
      retaining skilled labor include tying education to service commitment and
      developing protocols for even complex processes. Equipment and support services
      need to focus on technologies that are affordable and sustainable. Ethical
      decision making must be based on data when possible and on transparent
      articulated policies always. Research should be performed in resource-poor
      settings and focus on needs assessment, prognostication, and cost effectiveness. 
      FUTURE DIRECTIONS: The development of critical care in resource-poor settings
      will rely on the stepwise introduction of service improvements, leveraging human 
      resources through training, a focus on sustainable technology, ongoing analysis
      of cost effectiveness, and the sharing of context-specific best practices.
      Although prevention, public health, and disease-specific agendas dominate many
      current conversations in global health, this is nonetheless a time ripe for the
      development of critical care. Leaders in global health funding hope to improve
      quality and length of life. Critical care is an integral part of the continuum of
      care necessary to make that possible.
FAU - Riviello, Elisabeth D
AU  - Riviello ED
AD  - Brigham and Women's Hospital, Department of Internal Medicine, Boston, MA, USA.
      beth_riviello@post.harvard.edu
FAU - Letchford, Stephen
AU  - Letchford S
FAU - Achieng, Loice
AU  - Achieng L
FAU - Newton, Mark W
AU  - Newton MW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Crit Care Med
JT  - Critical care medicine
JID - 0355501
SB  - IM
CIN - Crit Care Med. 2011 Apr;39(4):916-7. PMID: 21613856
CIN - Crit Care Med. 2011 Oct;39(10):2385; author reply 2385-6. PMID: 21926511
MH  - Biomedical Research/ethics
MH  - Biomedical Technology
MH  - Cost-Benefit Analysis
MH  - *Critical Care/ethics/organization & administration/standards/trends
MH  - *Developing Countries
MH  - Education, Medical
MH  - Forecasting
MH  - Health Priorities
MH  - Health Resources
MH  - Humans
MH  - Kenya
MH  - Respiration, Artificial
MH  - Workforce
EDAT- 2011/02/08 06:00
MHDA- 2011/07/30 06:00
CRDT- 2011/02/08 06:00
PHST- 2011/02/08 06:00 [entrez]
PHST- 2011/02/08 06:00 [pubmed]
PHST- 2011/07/30 06:00 [medline]
AID - 10.1097/CCM.0b013e318206d6d5 [doi]
PST - ppublish
SO  - Crit Care Med. 2011 Apr;39(4):860-7. doi: 10.1097/CCM.0b013e318206d6d5.


PMID- 21296857
OWN - NLM
STAT- MEDLINE
DCOM- 20110421
LR  - 20110225
IS  - 1526-7598 (Electronic)
IS  - 0003-2999 (Linking)
VI  - 112
IP  - 3
DP  - 2011 Mar
TI  - Biomedical research in Germany: the role of ethics committee and state medical
      association.
PG  - 501-3
LID - 10.1213/ANE.0b013e31820acb75 [doi]
FAU - Hoffart, Jurgen
AU  - Hoffart J
FAU - Teichmann, Arndt
AU  - Teichmann A
FAU - Wessler, Ignaz
AU  - Wessler I
LA  - eng
PT  - Editorial
DEP - 20110204
PL  - United States
TA  - Anesth Analg
JT  - Anesthesia and analgesia
JID - 1310650
SB  - IM
MH  - Biomedical Research/*ethics/standards
MH  - Ethics Committees, Research/*ethics/standards
MH  - Germany
MH  - Humans
MH  - Physicians/ethics/standards
MH  - State Medicine/*ethics/standards
EDAT- 2011/02/08 06:00
MHDA- 2011/04/22 06:00
CRDT- 2011/02/08 06:00
PHST- 2011/02/08 06:00 [entrez]
PHST- 2011/02/08 06:00 [pubmed]
PHST- 2011/04/22 06:00 [medline]
AID - ANE.0b013e31820acb75 [pii]
AID - 10.1213/ANE.0b013e31820acb75 [doi]
PST - ppublish
SO  - Anesth Analg. 2011 Mar;112(3):501-3. doi: 10.1213/ANE.0b013e31820acb75. Epub 2011
      Feb 4.


PMID- 21296323
OWN - NLM
STAT- MEDLINE
DCOM- 20110523
LR  - 20211020
IS  - 1879-1913 (Electronic)
IS  - 0002-9149 (Linking)
VI  - 107
IP  - 7
DP  - 2011 Apr 1
TI  - Ethical and legal views regarding deactivation of cardiac implantable electrical 
      devices in patients with hypertrophic cardiomyopathy.
PG  - 1071-1075.e5
LID - 10.1016/j.amjcard.2010.11.036 [doi]
AB  - Little is known about patients' views surrounding the ethical and legal aspects
      of managing pacemakers (PMs) and implantable cardioverter-defibrillators (ICDs)
      near the end of life. Patients with hypertrophic cardiomyopathy (HC) are at
      heightened risk of sudden cardiac death and are common recipients of such
      devices. Patients with HC recruited from the membership of the Hypertrophic
      Cardiomyopathy Association were surveyed about their clinical histories, advance 
      care planning, legal knowledge, and ethical beliefs relating to the withdrawal of
      PM and ICD therapy. The mean age of the 546 patients was 49.1 years, 47% were
      women, and 57% had ICDs. Only 46% of the respondents had completed an advance
      directive, only 51% had a healthcare proxy, and cardiac implantable electrical
      devices (CIEDs) were commonly not addressed in either (92% and 58%,
      respectively). Many patients characterized deactivating PMs or ICDs as euthanasia
      or physician-assisted suicide (29% for PMs and 17% for ICDs), and >50% expressed 
      uncertainty regarding the legality of device deactivation. Patients viewed
      deactivation of ICDs and PMs as morally different from other life-sustaining
      therapies such as mechanical ventilation and dialysis, and these views varied
      substantially according to the CIED type (p <0.0001). The respondents expressed
      concerns regarding clinical conflicts related to religion, ethical and legal
      uncertainty, and informed consent. In conclusion, patients who have, or are
      eligible to receive, CIEDs might require improved advance care planning and
      education regarding the ethical and legal options for managing CIEDs at the end
      of life.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Kramer, Daniel B
AU  - Kramer DB
AD  - CardioVascular Institute, Beth Israel Deaconess Medical Center and Harvard
      Medical School, Boston, Massachusetts, USA. dkramer@bidmc.harvard.edu
FAU - Kesselheim, Aaron S
AU  - Kesselheim AS
FAU - Salberg, Lisa
AU  - Salberg L
FAU - Brock, Dan W
AU  - Brock DW
FAU - Maisel, William H
AU  - Maisel WH
LA  - eng
GR  - UL1 RR025758/RR/NCRR NIH HHS/United States
GR  - UL1 RR025758-01/RR/NCRR NIH HHS/United States
GR  - UL1 RR 025758/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110204
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
SB  - IM
MH  - Adult
MH  - Advance Directives/ethics
MH  - Aged
MH  - Cardiomyopathy, Hypertrophic/mortality/*therapy
MH  - Cardiopulmonary Resuscitation/ethics
MH  - Death, Sudden, Cardiac/etiology/prevention & control
MH  - Defibrillators, Implantable/*ethics
MH  - *Ethics, Medical
MH  - Female
MH  - Humans
MH  - Informed Consent/ethics/legislation & jurisprudence
MH  - Legal Guardians
MH  - Male
MH  - Middle Aged
MH  - Pacemaker, Artificial/*ethics
MH  - Patient Participation/legislation & jurisprudence
MH  - Societies, Medical
MH  - Terminal Care/*ethics/*legislation & jurisprudence
MH  - Withholding Treatment/*ethics/*legislation & jurisprudence
PMC - PMC3601901
MID - NIHMS272688
EDAT- 2011/02/08 06:00
MHDA- 2011/05/24 06:00
CRDT- 2011/02/08 06:00
PHST- 2010/10/25 00:00 [received]
PHST- 2010/11/12 00:00 [revised]
PHST- 2010/11/12 00:00 [accepted]
PHST- 2011/02/08 06:00 [entrez]
PHST- 2011/02/08 06:00 [pubmed]
PHST- 2011/05/24 06:00 [medline]
AID - S0002-9149(10)02603-2 [pii]
AID - 10.1016/j.amjcard.2010.11.036 [doi]
PST - ppublish
SO  - Am J Cardiol. 2011 Apr 1;107(7):1071-1075.e5. doi: 10.1016/j.amjcard.2010.11.036.
      Epub 2011 Feb 4.


PMID- 21296077
OWN - NLM
STAT- MEDLINE
DCOM- 20110517
LR  - 20151119
IS  - 1090-2449 (Electronic)
IS  - 0014-4894 (Linking)
VI  - 128
IP  - 1
DP  - 2011 May
TI  - Toxoplasma gondii RH Ankara: production of evolving tachyzoites using a novel
      cell culture method.
PG  - 1-8
LID - 10.1016/j.exppara.2011.01.019 [doi]
AB  - Toxoplasma gondii is one of the most researched parasite due to its easy growth
      both in vitro and in vivo. Tachyzoites, derived from mouse or rat peritoneum
      encounters ethical and economical problems when used for research or diagnostic
      purposes. Currently, research has focused on determining the most suitable cell
      culture environment to reach highest amount of viable tachyzoites with least host
      cell contamination. However, gene expression changes that take place throughout
      the adaptation of evolving T. gondii strains to continuous cell cultures appear
      as a problem. The present study aimed to determine a novel cell culture strategy 
      for T. gondii RH Ankara strain tachyzoites to harvest abundant tachyzoites with
      least host cell contamination and minimal antigenic variation at predetermined
      dates to use as an antigen source in serological assays that will facilitate
      reduction in animal use. To achieve this purpose, T. gondii RH Ankara strain
      tachyzoites were incubated with HeLa cell at different ratios for two or three
      days. In all flasks incubated for two days, viability rate reached to 100% and
      HeLa cell contamination decreased to levels between 0.12-0.5x10(6)/ml. In the
      flasks with HeLa-tachyzoite ratio 1/8, the tachyzoite yield and viability ratio
      were 3x10(6)/ml and 100%, respectively, with accompanying 10 fold decrease
      (0.12x10(6)/ml) in HeLa contamination. During continuous production, highest
      tachyzoite yield was obtained from the first passage (3.55x10(6)/ml) and until
      the end of third subculture viability rates and HeLa cell contaminations were
      between 98.2-99.4% and 0.31-0.37x10(6)/ml, respectively. ELISA, IFA and Western
      blot analyses showed that the quality, specificity and sensitivity of the antigen
      harvested from the first passage of cell culture performed at two days intervals 
      were comparable to the antigen harvested from mice and decreased in the following
      subcultures. Overall, these results demonstrated that T. gondii RH Ankara strain 
      is still evolving to adapt to cell culture environment and therefore such strains
      continuously produced in cell cultures should be avoided for serological assays. 
      However, the two day short interval cell culture method described herein offers a
      chance to reduce the animal use intended for the preparation of serological
      assays' antigen from local evolving strains.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Degirmenci, Aysu
AU  - Degirmenci A
AD  - Department of Parasitology, Ege University Medical School, Bornova/Izmir, Turkey.
FAU - Doskaya, Mert
AU  - Doskaya M
FAU - Caner, Ayse
AU  - Caner A
FAU - Cicek, Candan
AU  - Cicek C
FAU - Korkmaz, Metin
AU  - Korkmaz M
FAU - Guruz, Yuksel
AU  - Guruz Y
FAU - Uner, Ahmet
AU  - Uner A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110204
PL  - United States
TA  - Exp Parasitol
JT  - Experimental parasitology
JID - 0370713
RN  - 0 (Antibodies, Protozoan)
RN  - 0 (Antigens, Protozoan)
SB  - IM
MH  - Animal Testing Alternatives
MH  - Animals
MH  - Antibodies, Protozoan/blood/immunology
MH  - Antigens, Protozoan/immunology
MH  - Blotting, Western
MH  - Electrophoresis, Polyacrylamide Gel
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Fluorescent Antibody Technique
MH  - HeLa Cells
MH  - Humans
MH  - Infant, Newborn
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Toxoplasma/*growth & development/immunology
MH  - Toxoplasmosis, Congenital/diagnosis/parasitology
EDAT- 2011/02/08 06:00
MHDA- 2011/05/18 06:00
CRDT- 2011/02/08 06:00
PHST- 2010/08/02 00:00 [received]
PHST- 2011/01/26 00:00 [revised]
PHST- 2011/01/27 00:00 [accepted]
PHST- 2011/02/08 06:00 [entrez]
PHST- 2011/02/08 06:00 [pubmed]
PHST- 2011/05/18 06:00 [medline]
AID - S0014-4894(11)00030-0 [pii]
AID - 10.1016/j.exppara.2011.01.019 [doi]
PST - ppublish
SO  - Exp Parasitol. 2011 May;128(1):1-8. doi: 10.1016/j.exppara.2011.01.019. Epub 2011
      Feb 4.


PMID- 21295895
OWN - NLM
STAT- MEDLINE
DCOM- 20110719
LR  - 20161125
IS  - 1532-2793 (Electronic)
IS  - 0260-6917 (Linking)
VI  - 31
IP  - 3
DP  - 2011 Apr
TI  - Plethora or paucity: a systematic search and bibliometric study of the
      application and design of qualitative methods in nursing research 2008-2010.
PG  - 299-303
LID - 10.1016/j.nedt.2010.12.002 [doi]
AB  - Qualitative methodology has increased in application and acceptability in all
      research disciplines. In nursing, it is appropriate that a plethora of
      qualitative methods can be found as nurses pose real-world questions to clinical,
      cultural and ethical issues of patient care (Johnson, 2007; Long and Johnson,
      2007), yet the methods nurses readily use in pursuit of answers remains under
      intense scrutiny. One of the problems with qualitative methodology for nursing
      research is its place in the hierarchy of evidence (HOE); another is its
      comparison to the positivist constructs of what constitutes good research and the
      measurement of qualitative research against this. In order to position and
      strengthen its evidence base, nursing may well seek to distance itself from a
      qualitative perspective and utilise methods at the top of the HOE; yet given the 
      relation of qualitative methods to nursing this would constrain rather than
      broaden the profession in search of answers and an evidence base. The comparison 
      between qualitative and quantitative can be both mutually exclusive and
      rhetorical, by shifting the comparison this study takes a more reflexive position
      and critically appraises qualitative methods against the standards set by
      qualitative researchers. By comparing the design and application of qualitative
      methods in nursing over a two year period, the study examined how qualitative
      stands up to independent rather than comparative scrutiny. For the methods, a
      four-step mixed methods approach newly constructed by the first author was used
      to define the scope of the research question and develop inclusion criteria. 2.
      Synthesis tables were constructed to organise data, 3. Bibliometrics configured
      data. 4. Studies selected for inclusion in the review were critically appraised
      using a critical interpretive synthesis (Dixon-Woods et al., 2006). The paper
      outlines the research process as well as findings. Results showed of the 240
      papers analysed, 27% used ad hoc or no references to qualitative; methodological 
      terms such as thematic analysis or constant comparative methods were used
      inconsistently; qualitative was a catch-all panacea rather than a methodology
      with well-argued terms or contextual definition.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Ball, Elaine
AU  - Ball E
AD  - University of Salford, College of Health & Social Care, Manchester M6 6PU, United
      Kingdom. e.ball1@salford.ac.uk
FAU - McLoughlin, Moira
AU  - McLoughlin M
FAU - Darvill, Angela
AU  - Darvill A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110205
PL  - Scotland
TA  - Nurse Educ Today
JT  - Nurse education today
JID - 8511379
MH  - *Bibliometrics
MH  - Humans
MH  - Nursing Research/*methods/statistics & numerical data/trends
MH  - Periodicals as Topic
MH  - *Qualitative Research
MH  - Research Design
MH  - United Kingdom
EDAT- 2011/02/08 06:00
MHDA- 2011/07/20 06:00
CRDT- 2011/02/08 06:00
PHST- 2010/06/16 00:00 [received]
PHST- 2010/12/01 00:00 [revised]
PHST- 2010/12/02 00:00 [accepted]
PHST- 2011/02/08 06:00 [entrez]
PHST- 2011/02/08 06:00 [pubmed]
PHST- 2011/07/20 06:00 [medline]
AID - S0260-6917(10)00253-4 [pii]
AID - 10.1016/j.nedt.2010.12.002 [doi]
PST - ppublish
SO  - Nurse Educ Today. 2011 Apr;31(3):299-303. doi: 10.1016/j.nedt.2010.12.002. Epub
      2011 Feb 5.


PMID- 21295423
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20110328
IS  - 1873-4111 (Electronic)
IS  - 0378-5122 (Linking)
VI  - 68
IP  - 4
DP  - 2011 Apr
TI  - Body weight as an indicator of fat-free mass in active elderly women.
PG  - 378-81
LID - 10.1016/j.maturitas.2011.01.007 [doi]
AB  - OBJECTIVE: Fat-free mass (FFM) reduction and the tendency for a reduction in
      surrounding fatty issue and increase in the middle are a natural consequence of
      growing old and should be studied in order to gain a better understanding of the 
      aging process. This study set out to find the FFM differences between active
      elderly women in two age groups (60-69 and 70-80 years) and to determine which of
      the anthropometric measurements, body weight (BW), abdominal circumference (AC), 
      or body mass index (BMI) are the best predictors of FFM variation within the
      group. METHODS: Eighty-one (n=81) active elderly women of the Third Age willingly
      signed up to participate in the research during the activities at the University 
      of the Third Age (UTA) in Brazil. The research was approved by the Research
      Ethics Committee of the Faculty of Medical Sciences of the State University of
      Campinas (UNICAMP). Body weight (BW), height (H) and the BMI were measured
      according to the international standards. The AC was measured in centimetres at
      the H of the navel and body composition was ascertained using bioimpedance
      analysis. The SAS program was used to perform the statistical analysis of
      independent samples and parametric data. RESULTS: The results showed FFM values
      with significant differences between the two groups, with the lowest values
      occurring among the women who were over 70 years of age. In the analysis, the
      Pearson's Correlation Coefficient for each measured independent variable was
      ascertained, with the BW measurement showing the highest ratio (0.900).
      CONCLUSIONS: The BW measurement was regarded as reliable, low-cost and easy to
      use for monitoring FFM in elderly women who engage in physical activities.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Sonati, Jaqueline G
AU  - Sonati JG
AD  - State University of Campinas (UNICAMP), University Campus Zeferino Vaz, Physical 
      Education Institute, Department for Adapted Physical Activity Studies, Rua Erico 
      Verissimo, 701, Zip: 13083-851, PO Box 6134, Campinas, Sao Paulo, Brazil.
      j.girnos@gmail.com
FAU - Modeneze, Denis M
AU  - Modeneze DM
FAU - Vilarta, Roberto
AU  - Vilarta R
FAU - Maciel, Erika S
AU  - Maciel ES
FAU - Boccaletto, Estela M A
AU  - Boccaletto EM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110203
PL  - Ireland
TA  - Maturitas
JT  - Maturitas
JID - 7807333
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*physiology
MH  - Body Composition/*physiology
MH  - Body Fluid Compartments/*physiology
MH  - Body Weight/*physiology
MH  - Brazil
MH  - Exercise/*physiology
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Reproducibility of Results
EDAT- 2011/02/08 06:00
MHDA- 2011/11/09 06:00
CRDT- 2011/02/08 06:00
PHST- 2010/08/20 00:00 [received]
PHST- 2011/01/06 00:00 [revised]
PHST- 2011/01/07 00:00 [accepted]
PHST- 2011/02/08 06:00 [entrez]
PHST- 2011/02/08 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - S0378-5122(11)00008-9 [pii]
AID - 10.1016/j.maturitas.2011.01.007 [doi]
PST - ppublish
SO  - Maturitas. 2011 Apr;68(4):378-81. doi: 10.1016/j.maturitas.2011.01.007. Epub 2011
      Feb 3.


PMID- 21294459
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20190923
IS  - 0743-2550 (Print)
IS  - 0743-2550 (Linking)
VI  - 28
IP  - 1
DP  - 2011 Jan-Mar
TI  - The place of dignity in everyday ethics.
PG  - 12-8; quiz 19-20
AB  - Although ethics is often thought of in terms of "life-and-death" matters, many
      everyday situations involve ethics. Human dignity, a more recent way of
      expressing the belief that humans are made in the image of God (Genesis 1:26),
      captures the controversial notion that all humans are uniquely valuable and ought
      to be esteemed highly. Nurses have great opportunity to promote or demote
      dignity. A Christian holistic approach to ethics, exemplified by the narrative of
      the Good Samaritan (Luke 10:25-37), acknowledges the difficulty of always being
      ethical and integrates feeling, thinking, acting, and spirituality.
FAU - O'Mathuna, Donal P
AU  - O'Mathuna DP
AD  - School of Nursing, Dublin City University, Ireland.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Christ Nurs
JT  - Journal of Christian nursing : a quarterly publication of Nurses Christian
      Fellowship
JID - 8411743
MH  - *Christianity
MH  - Education, Nursing, Continuing
MH  - Holistic Nursing/*ethics
MH  - Humans
MH  - Models, Nursing
MH  - Narration
MH  - Nurse-Patient Relations/*ethics
MH  - *Personhood
EDAT- 2011/02/08 06:00
MHDA- 2011/02/25 06:00
CRDT- 2011/02/08 06:00
PHST- 2011/02/08 06:00 [entrez]
PHST- 2011/02/08 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - 10.1097/cnj.0b013e3181fe7606 [doi]
PST - ppublish
SO  - J Christ Nurs. 2011 Jan-Mar;28(1):12-8; quiz 19-20. doi:
      10.1097/cnj.0b013e3181fe7606.


PMID- 21294458
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20190923
IS  - 0743-2550 (Print)
IS  - 0743-2550 (Linking)
VI  - 28
IP  - 1
DP  - 2011 Jan-Mar
TI  - Ethics and empathy (Part one).
PG  - 11
FAU - Salladay, Susan A
AU  - Salladay SA
AD  - Cedarville University, Ohio, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Christ Nurs
JT  - Journal of Christian nursing : a quarterly publication of Nurses Christian
      Fellowship
JID - 8411743
MH  - *Altruism
MH  - Animals
MH  - *Behavior, Animal
MH  - *Christianity
MH  - Empathy/*ethics
MH  - *Ethics, Nursing
MH  - Humans
EDAT- 2011/02/08 06:00
MHDA- 2011/02/25 06:00
CRDT- 2011/02/08 06:00
PHST- 2011/02/08 06:00 [entrez]
PHST- 2011/02/08 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - 10.1097/cnj.0b013e3181ff022c [doi]
PST - ppublish
SO  - J Christ Nurs. 2011 Jan-Mar;28(1):11. doi: 10.1097/cnj.0b013e3181ff022c.


PMID- 21294118
OWN - NLM
STAT- MEDLINE
DCOM- 20110324
LR  - 20110204
IS  - 1096-9896 (Electronic)
IS  - 0022-3417 (Linking)
VI  - 223
IP  - 4
DP  - 2011 Mar
TI  - The Journal of Pathology's approach to publication ethics and misconduct.
PG  - 447-9
LID - 10.1002/path.2843 [doi]
AB  - This Editorial highlights recent changes at The Journal of Pathology intended to 
      improve our ability to detect, and we hope deter, instances of ethical misconduct
      among submissions made to the Journal, such as cases of guest authorship and
      plagiarism. We also discuss our experience to date and describe our policies for 
      dealing with such cases. These changes are all encapsulated in our full online
      Author Guidelines.
CI  - Copyright (c) 2011 Pathological Society of Great Britain and Ireland. Published
      by John Wiley & Sons, Ltd.
FAU - Hall, Peter A
AU  - Hall PA
FAU - Wixon, Jo
AU  - Wixon J
FAU - Poulsom, Richard
AU  - Poulsom R
LA  - eng
PT  - Editorial
PL  - England
TA  - J Pathol
JT  - The Journal of pathology
JID - 0204634
SB  - IM
MH  - Pathology/*ethics
MH  - Periodicals as Topic/*ethics
MH  - Plagiarism
MH  - Publishing/*ethics
MH  - Scientific Misconduct/*ethics
EDAT- 2011/02/05 06:00
MHDA- 2011/03/25 06:00
CRDT- 2011/02/05 06:00
PHST- 2011/02/05 06:00 [entrez]
PHST- 2011/02/05 06:00 [pubmed]
PHST- 2011/03/25 06:00 [medline]
AID - 10.1002/path.2843 [doi]
PST - ppublish
SO  - J Pathol. 2011 Mar;223(4):447-9. doi: 10.1002/path.2843.


PMID- 21294028
OWN - NLM
STAT- MEDLINE
DCOM- 20110601
LR  - 20110616
IS  - 1540-3602 (Electronic)
IS  - 0091-8369 (Linking)
VI  - 58
IP  - 2
DP  - 2011
TI  - Core American values and the structure of antigay prejudice.
PG  - 248-62
LID - 10.1080/00918369.2011.540180 [doi]
AB  - This work presents a new scale to measure conflicting attitudes toward sexual
      minorities. This scale parallels existing measures of conflicting racial
      attitudes (anti-Black and pro-Black attitudes; Katz & Hass, 1988). After
      constructing and validating measures of antigay and progay attitudes, we tested
      relationships among core American values with racial and sexual minority
      attitudes. We examined relations among the Protestant Work Ethic (PWE),
      Traditional Family Ideology (TFI), and egalitarian values with attitudes toward
      racial outgroups and sexual minorities. The results revealed that both PWE values
      and egalitarian values predicted anti-Black attitudes. By contrast, endorsement
      of egalitarian values, but not PWE values, predicted pro-Black attitudes. Results
      also revealed a similar but distinct pattern among values and heterosexuals'
      attitudes toward sexual minorities. TFI, but not egalitarian value endorsement,
      predicted antigay attitudes, whereas both TFI and egalitarian value endorsement
      predicted progay attitudes. The implications of these findings are discussed.
FAU - Callahan, Matthew Paolucci
AU  - Callahan MP
AD  - Department of Psychology, Sonoma State University, Rohnert Park, CA 94928, USA.
      paolucci@sonoma.edu
FAU - Vescio, Theresa K
AU  - Vescio TK
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Homosex
JT  - Journal of homosexuality
JID - 7502386
SB  - IM
MH  - African Americans/psychology
MH  - Attitude
MH  - Data Collection
MH  - Family/psychology
MH  - Female
MH  - *Homosexuality/psychology
MH  - Homosexuality, Female/psychology
MH  - Homosexuality, Male/psychology
MH  - Humans
MH  - Male
MH  - Minority Groups/psychology
MH  - *Prejudice
MH  - Reproducibility of Results
MH  - *Social Values
MH  - Stereotyping
MH  - United States
EDAT- 2011/02/05 06:00
MHDA- 2011/06/02 06:00
CRDT- 2011/02/05 06:00
PHST- 2011/02/05 06:00 [entrez]
PHST- 2011/02/05 06:00 [pubmed]
PHST- 2011/06/02 06:00 [medline]
AID - 933046897 [pii]
AID - 10.1080/00918369.2011.540180 [doi]
PST - ppublish
SO  - J Homosex. 2011;58(2):248-62. doi: 10.1080/00918369.2011.540180.


PMID- 21293481
OWN - NLM
STAT- MEDLINE
DCOM- 20120109
LR  - 20211203
IS  - 1476-5624 (Electronic)
IS  - 1362-4393 (Linking)
VI  - 49
IP  - 2
DP  - 2011 Feb
TI  - Ethics, healthcare and spinal cord injury: research, practice and finance.
PG  - 161
LID - 10.1038/sc.2010.195 [doi]
FAU - Wyndaele, J J
AU  - Wyndaele JJ
LA  - eng
PT  - Editorial
PT  - Introductory Journal Article
PL  - England
TA  - Spinal Cord
JT  - Spinal cord
JID - 9609749
SB  - IM
MH  - Delivery of Health Care/economics/*ethics
MH  - Ethics, Medical/*education
MH  - Health Care Costs/trends
MH  - Humans
MH  - Spinal Cord Injuries/economics/*psychology/therapy
MH  - Translational Research, Biomedical/economics/trends
MH  - Withholding Treatment/economics/*ethics
EDAT- 2011/02/05 06:00
MHDA- 2012/01/10 06:00
CRDT- 2011/02/05 06:00
PHST- 2011/02/05 06:00 [entrez]
PHST- 2011/02/05 06:00 [pubmed]
PHST- 2012/01/10 06:00 [medline]
AID - sc2010195 [pii]
AID - 10.1038/sc.2010.195 [doi]
PST - ppublish
SO  - Spinal Cord. 2011 Feb;49(2):161. doi: 10.1038/sc.2010.195.


PMID- 21293267
OWN - NLM
STAT- MEDLINE
DCOM- 20110701
LR  - 20220409
IS  - 1473-6500 (Electronic)
IS  - 0952-7907 (Linking)
VI  - 24
IP  - 2
DP  - 2011 Apr
TI  - Knowing when to stop: futility in the ICU.
PG  - 160-5
LID - 10.1097/ACO.0b013e328343c5af [doi]
AB  - PURPOSE OF REVIEW: Decisions to withdraw or withhold potentially life-sustaining 
      treatment are common in intensive care and precede the majority of deaths. When
      families resist or oppose doctors' suggestions that it is time to stop treatment,
      it is often unclear what should be done. This review will summarize recent
      literature around futility judgements in intensive care emphasising ethical and
      practical questions. RECENT FINDINGS: There has been a shift in the language of
      futility. Patients' families often do not believe medical assessments that
      further treatment would be unsuccessful. Attempts to determine through data
      collection which patients have a low or zero chance of survival have been largely
      unsuccessful, and are hampered by varying definitions of futility. A due-process 
      model for adjudicating futility disputes has been developed, and may provide a
      better solution to futility disputes than previous futility statutes. SUMMARY:
      Specific criteria for unilateral withdrawal of treatment have proved hard to
      define or defend. However, it is ethical for doctors to decline to provide
      treatment that is medically inappropriate or futile. Understanding the
      justification for a futility judgement may be relevant to deciding the most
      appropriate way to resolve futility disputes.
FAU - Wilkinson, Dominic J C
AU  - Wilkinson DJ
AD  - Institute for Science and Ethics, Department of Philosophy, University of Oxford,
      Oxford, UK. dominic.wilkinson@adelaide.edu.au
FAU - Savulescu, Julian
AU  - Savulescu J
LA  - eng
GR  - 086041/WT_/Wellcome Trust/United Kingdom
GR  - 086041/Z/08/Z/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Curr Opin Anaesthesiol
JT  - Current opinion in anaesthesiology
JID - 8813436
SB  - IM
MH  - Critical Care/*ethics/standards
MH  - Euthanasia, Passive
MH  - Humans
MH  - Intensive Care Units/*ethics/standards
MH  - Medical Futility/*ethics
MH  - Resuscitation Orders
MH  - Withholding Treatment
PMC - PMC3252683
MID - UKMS40140
OID - NLM: UKMS40140
EDAT- 2011/02/05 06:00
MHDA- 2011/07/02 06:00
CRDT- 2011/02/05 06:00
PHST- 2011/02/05 06:00 [entrez]
PHST- 2011/02/05 06:00 [pubmed]
PHST- 2011/07/02 06:00 [medline]
AID - 10.1097/ACO.0b013e328343c5af [doi]
PST - ppublish
SO  - Curr Opin Anaesthesiol. 2011 Apr;24(2):160-5. doi: 10.1097/ACO.0b013e328343c5af.


PMID- 21293254
OWN - NLM
STAT- MEDLINE
DCOM- 20110414
LR  - 20220317
IS  - 1528-1175 (Electronic)
IS  - 0003-3022 (Linking)
VI  - 114
IP  - 3
DP  - 2011 Mar
TI  - Spinal macrophage migration inhibitory factor is a major contributor to rodent
      neuropathic pain-like hypersensitivity.
PG  - 643-59
LID - 10.1097/ALN.0b013e31820a4bf3 [doi]
AB  - BACKGROUND: Neuropathic pain-like hypersensitivity evoked by peripheral nerve
      injury is a salient clinical feature of pathologic pain; however, the underlying 
      mechanisms of this condition remain largely unknown. Previous work has confirmed 
      that spinal macrophage migration inhibitory factor (MIF) contributes to the
      pathogenesis of formalin-induced inflammatory hyperalgesia, but the role for MIF 
      in neuropathic pain is still not well defined. METHODS: After approval by the
      Ethical Committee of Animal Use and Care, the sciatic chronic constriction nerve 
      injury-induced rodent model of neuropathic pain was built. The mechanical
      threshold with von Frey hairs and thermal latency with hot plate were measured,
      and the expression of spinal MIF, CD74, and downstream extracellular
      signal-regulated kinase 1/2 signaling cascade was detected. Finally, MIF gene
      mutation and exogenous recombinant MIF were used for further clarification.
      RESULTS: Intrathecal MIF tautomerase inhibitor reversed sciatic chronic
      constriction nerve injury-induced pain behaviors. The expression of MIF and CD74 
      up-regulated in a time-dependent manner in the ipsilateral spinal cord dorsal
      horn. These changes were associated with the activation of extracellular
      signal-regulated kinase 1/2 signaling by MIF/CD74 interaction, which subsequently
      led to up-regulation of interleukin-8 and N-methyl-D-aspartic acid receptor
      expression and additional production of prostaglandin E(2). Further, MIF gene
      mutation and exogenous recombinant MIF could desensitize and mimic sciatic
      chronic constriction nerve injury-evoked pain responses and cellular changes,
      respectively. CONCLUSIONS: MIF-associated extracellular signal-regulated kinase
      1/2-N-methyl-D-aspartic acid receptor or prostaglandin E(2) cascade accounts for 
      the changes in peripheral nerve injury-induced nociceptive responses.
FAU - Wang, FuZhou
AU  - Wang F
AD  - State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science,
      Nanjing University, Nanjing, China.
FAU - Xu, ShiQin
AU  - Xu S
FAU - Shen, XiaoFeng
AU  - Shen X
FAU - Guo, XiRong
AU  - Guo X
FAU - Peng, YuZhu
AU  - Peng Y
FAU - Yang, Jie
AU  - Yang J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Anesthesiology
JT  - Anesthesiology
JID - 1300217
RN  - 0 (Antigens, Differentiation, B-Lymphocyte)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Macrophage Migration-Inhibitory Factors)
RN  - 0 (invariant chain)
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
RN  - K7Q1JQR04M (Dinoprostone)
SB  - IM
MH  - Animals
MH  - Antigens, Differentiation, B-Lymphocyte/metabolism
MH  - Blotting, Western
MH  - Dinoprostone/metabolism
MH  - Electrophysiological Phenomena
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Excitatory Postsynaptic Potentials/drug effects
MH  - Extracellular Signal-Regulated MAP Kinases/metabolism
MH  - Histocompatibility Antigens Class II/metabolism
MH  - Hot Temperature
MH  - Hyperalgesia/*physiopathology
MH  - Immunohistochemistry
MH  - Injections, Spinal
MH  - Macrophage Migration-Inhibitory Factors/antagonists &
      inhibitors/metabolism/*physiology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neuralgia/*physiopathology
MH  - Pain Threshold/physiology
MH  - Physical Stimulation
MH  - Sciatic Neuropathy/physiopathology
MH  - Signal Transduction/physiology
MH  - Spinal Cord/metabolism/*physiology
EDAT- 2011/02/05 06:00
MHDA- 2011/04/16 06:00
CRDT- 2011/02/05 06:00
PHST- 2011/02/05 06:00 [entrez]
PHST- 2011/02/05 06:00 [pubmed]
PHST- 2011/04/16 06:00 [medline]
AID - 10.1097/ALN.0b013e31820a4bf3 [doi]
PST - ppublish
SO  - Anesthesiology. 2011 Mar;114(3):643-59. doi: 10.1097/ALN.0b013e31820a4bf3.


PMID- 21293038
OWN - NLM
STAT- MEDLINE
DCOM- 20110317
LR  - 20110204
IS  - 1930-7837 (Electronic)
IS  - 0022-0337 (Linking)
VI  - 75
IP  - 2
DP  - 2011 Feb
TI  - A model for overview of student learning: a matrix of educational outcomes versus
      methodologies.
PG  - 160-8
AB  - A concise overview of an institution's aspirations for its students becomes
      increasingly elusive because dental education has evolving emphases on priorities
      like critical thinking and adapting to new technology. The purpose of this
      article is to offer a learner-oriented matrix that gives a focus for discussion
      and an overview of an institution's educational outcomes. On one axis of the
      matrix, common educational outcomes are listed: knowledge, technical skills,
      critical thinking, ethical and professional values, patient and practice
      management, and social responsibility awareness. On the other axis, methodologies
      are listed: definition, cultivation strategies, measures (summative/formative,
      objective/subjective), institutional coordination, and competency determination. 
      By completing the matrix, an overview of the process by which students reach
      these outcomes emerges. Each institution would likely complete the matrix
      differently and, ideally, with active discussion. While the matrix can first be
      used to establish "Where are we now?" for an institution, it can also be a
      starting point for more extensive matrices and further discussion. Vertical and
      horizontal analyses of the matrix provide a unique lens for viewing the
      institution's learning environment.
FAU - Johnsen, David C
AU  - Johnsen DC
AD  - College of Dentistry, University of Iowa, 300 Dental Science N, Iowa City, IA
      52242, USA. david-johnsen@uiowa.edu
FAU - Marshall, Teresa A
AU  - Marshall TA
FAU - Finkelstein, Michael W
AU  - Finkelstein MW
FAU - Cunningham-Ford, Marsha A
AU  - Cunningham-Ford MA
FAU - Straub-Morarend, Cheryl L
AU  - Straub-Morarend CL
FAU - Holmes, David C
AU  - Holmes DC
FAU - Armstrong, Steven R
AU  - Armstrong SR
FAU - Aquilino, Steven A
AU  - Aquilino SA
FAU - Sharp, Helen M
AU  - Sharp HM
FAU - Solow, Catherine M
AU  - Solow CM
FAU - McQuistan, Michelle R
AU  - McQuistan MR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Dent Educ
JT  - Journal of dental education
JID - 8000150
SB  - IM
MH  - Clinical Competence
MH  - Curriculum
MH  - Dental Care
MH  - Dentist-Patient Relations
MH  - *Education, Dental/standards
MH  - Educational Measurement
MH  - Educational Technology
MH  - Ethics, Dental
MH  - Evidence-Based Dentistry/education
MH  - Faculty, Dental
MH  - Humans
MH  - *Learning
MH  - *Models, Educational
MH  - Practice Management, Dental
MH  - Schools, Dental/standards
MH  - Social Responsibility
MH  - Social Values
MH  - *Students, Dental
MH  - Teaching/methods
MH  - Thinking
EDAT- 2011/02/05 06:00
MHDA- 2011/03/18 06:00
CRDT- 2011/02/05 06:00
PHST- 2011/02/05 06:00 [entrez]
PHST- 2011/02/05 06:00 [pubmed]
PHST- 2011/03/18 06:00 [medline]
AID - 75/2/160 [pii]
PST - ppublish
SO  - J Dent Educ. 2011 Feb;75(2):160-8.


PMID- 21292868
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20110419
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 259
IP  - 2
DP  - 2011 May
TI  - Fracture risk score and absolute risk of fracture.
PG  - 495-501
LID - 10.1148/radiol.10101406 [doi]
AB  - PURPOSE: To report the 5- and 10-year absolute risk of fracture associated with
      the previously reported fracture risk (FRISK) score. MATERIALS AND METHODS: All
      participants gave written, informed consent, and the Barwon Health Human Research
      Ethics Committee approved the study. An age-stratified population-based sample of
      women aged 60 years and older (n = 600) was recruited during 1994-1996. FRISK
      scores of 0-10 incorporating bone mineral density (BMD) at two sites (hip and
      spine), falls scores in the previous 12 months of 1-4, weight, and number of
      fractures as an adult were calculated. Fractures of the hip, spine, humerus, and 
      wrist were ascertained during a median follow-up period of 9.6 years
      (interquartile range, 6.6-10.5). The cumulative probability of fracture at 5 and 
      10 years after baseline measurements was calculated by using actuarial methods.
      The utility of this model was compared with other FRISK algorithms, including the
      World Health Organization FRISK assessment tool FRAX designed for United Kingdom 
      and that designed for the United States and the Garvan nomogram (Australia).
      RESULTS: This study supplies the 5- and 10-year absolute risk of fracture
      associated with all levels of the FRISK score. While there are modest differences
      in absolute risk of fracture seen for different numbers of prior fractures, the
      more marked differences occur across the different categories of falls scores and
      different categories of BMD. The receiver operating characteristic curves showed 
      no significant difference in area under the curve for all four absolute risk of
      fracture algorithms. CONCLUSION: Absolute risk of fracture can be determined by
      using readily obtainable clinical information that may aid treatment decisions.
CI  - RSNA, 2011
FAU - Henry, Margaret J
AU  - Henry MJ
AD  - Department of Clinical and Biomedical Sciences-Barwon Health, Epidemiology and
      Biostatistics Unit, University of Melbourne, PO Box 281, Geelong, VIC 3220,
      Australia. margh@BarwonHealth.org.au
FAU - Pasco, Julie A
AU  - Pasco JA
FAU - Merriman, Elizabeth N
AU  - Merriman EN
FAU - Zhang, Yu
AU  - Zhang Y
FAU - Sanders, Kerrie M
AU  - Sanders KM
FAU - Kotowicz, Mark A
AU  - Kotowicz MA
FAU - Nicholson, Geoffrey C
AU  - Nicholson GC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110203
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Algorithms
MH  - Area Under Curve
MH  - Bone Density
MH  - Female
MH  - Fractures, Bone/*etiology
MH  - Humans
MH  - Linear Models
MH  - Longitudinal Studies
MH  - Middle Aged
MH  - Osteoporosis, Postmenopausal/*complications
MH  - Prospective Studies
MH  - ROC Curve
MH  - Risk Assessment/*methods
MH  - Risk Factors
MH  - Sensitivity and Specificity
EDAT- 2011/02/05 06:00
MHDA- 2011/07/27 06:00
CRDT- 2011/02/05 06:00
PHST- 2011/02/05 06:00 [entrez]
PHST- 2011/02/05 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
AID - radiol.10101406 [pii]
AID - 10.1148/radiol.10101406 [doi]
PST - ppublish
SO  - Radiology. 2011 May;259(2):495-501. doi: 10.1148/radiol.10101406. Epub 2011 Feb
      3.


PMID- 21292724
OWN - NLM
STAT- MEDLINE
DCOM- 20120326
LR  - 20220321
IS  - 1465-735X (Electronic)
IS  - 0146-8693 (Linking)
VI  - 36
IP  - 10
DP  - 2011 Nov-Dec
TI  - Case study: An ethics case study of HIV prevention research on Facebook: the
      Just/Us study.
PG  - 1082-92
LID - 10.1093/jpepsy/jsq126 [doi]
AB  - OBJECTIVE: To consider issues related to research with youth on social networking
      sites online. METHODS: Description of the data collection process from 1,588
      participants in a randomized controlled trial testing the efficacy of HIV
      prevention education delivered on Facebook. Using respondent-driven sampling,
      staff-recruited participants are encouraged to recruit up to three friends to
      enroll in the study. RESULTS: Researchers should (a) consider whether an online
      social networking site is an appropriate place to implement a research study; (b)
      offer opportunities to review informed consent documents at multiple times and in
      multiple locations throughout the study; and (c) collect data outside the social 
      networking site and store it behind secure firewalls to ensure it will not be
      accessible to any person on the social networking site. CONCLUSIONS: Online
      social networks are growing in popularity. Conducting research on social media
      sites requires deliberate attention to consent, confidentiality, and security.
FAU - Bull, Sheana S
AU  - Bull SS
AD  - MPH, Colorado School of Public Health, University of Colorado Denver, 13001 East 
      17th Place, Building 500, Campus Box B-119, Aurora, CO 80045, USA.
      sheana.bull@ucdenver.edu
FAU - Breslin, Lindsey T
AU  - Breslin LT
FAU - Wright, Erin E
AU  - Wright EE
FAU - Black, Sandra R
AU  - Black SR
FAU - Levine, Deborah
AU  - Levine D
FAU - Santelli, John S
AU  - Santelli JS
LA  - eng
GR  - R01NR01492/NR/NINR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110203
PL  - United States
TA  - J Pediatr Psychol
JT  - Journal of pediatric psychology
JID - 7801773
SB  - IM
MH  - Adolescent
MH  - Blogging
MH  - Confidentiality/*ethics
MH  - Data Collection/*ethics
MH  - *Ethics, Research
MH  - Female
MH  - HIV Infections/*prevention & control
MH  - Humans
MH  - Male
MH  - *Social Networking
PMC - PMC3199441
EDAT- 2011/02/05 06:00
MHDA- 2012/03/27 06:00
CRDT- 2011/02/05 06:00
PHST- 2011/02/05 06:00 [entrez]
PHST- 2011/02/05 06:00 [pubmed]
PHST- 2012/03/27 06:00 [medline]
AID - jsq126 [pii]
AID - 10.1093/jpepsy/jsq126 [doi]
PST - ppublish
SO  - J Pediatr Psychol. 2011 Nov-Dec;36(10):1082-92. doi: 10.1093/jpepsy/jsq126. Epub 
      2011 Feb 3.


PMID- 21292700
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20110421
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 5
DP  - 2011 May
TI  - Parental procreative obligation and the categorisation of disease: the case of
      cystic fibrosis.
PG  - 280-4
LID - 10.1136/jme.2010.039230 [doi]
AB  - The advent of prenatal genetic diagnosis has sparked debates among ethicists and 
      philosophers regarding parental responsibility towards potential offspring. Some 
      have attempted to place moral obligations on parents to not bring about children 
      with certain diseases in order to prevent harm to such children. There has been
      no rigorous evaluation of cystic fibrosis in this context. This paper will
      demonstrate cystic fibrosis to have unique properties that make it difficult to
      categorize among other diseases with the goal of promulgating a reproductive
      rule. Once this is established, it will be demonstrated that procreative rules
      that appeal to future health are inadequate in the era of advancing genetic
      knowledge. Utilising a specification of Joel Feinberg's 'open future' concept
      outlined by Matteo Mameli, it will offer an analysis of parental obligation that 
      does not constrain parents of potential children with cystic fibrosis with a
      moral obligation not to bring them about.
FAU - Bosslet, Gabriel T
AU  - Bosslet GT
AD  - Department of Internal Medicine, Indiana University Medical Center, 1481 West
      10th Street, 111P-IU, Indianapolis, IN 46202, USA. gbosslet@iupui.edu
LA  - eng
PT  - Journal Article
DEP - 20110202
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Cystic Fibrosis/*genetics/psychology
MH  - Female
MH  - Genetic Counseling/*psychology
MH  - Genetic Diseases, Inborn/*prevention & control
MH  - Genetic Testing
MH  - Humans
MH  - Male
MH  - Parents/*psychology
MH  - Pregnancy
MH  - Prenatal Diagnosis/*psychology
EDAT- 2011/02/05 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/02/05 06:00
PHST- 2011/02/05 06:00 [entrez]
PHST- 2011/02/05 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - jme.2010.039230 [pii]
AID - 10.1136/jme.2010.039230 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 May;37(5):280-4. doi: 10.1136/jme.2010.039230. Epub 2011 Feb
      2.


PMID- 21292698
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20151119
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 6
DP  - 2011 Jun
TI  - Limitation of treatment at the end of life: an empirical-ethical analysis
      regarding the practices of physician members of the German Society for Palliative
      Medicine.
PG  - 327-32
LID - 10.1136/jme.2010.039248 [doi]
AB  - OBJECTIVES: To determine the frequencies and types of limitation of medical
      treatment performed by physician members of the German Society for Palliative
      Medicine and to analyse the findings with respect to clinical and ethical aspects
      of end-of-life practices. DESIGN: Cross-sectional postal survey. SETTING: Data
      collection via the secretary of the German Society for Palliative Medicine using 
      the German language version of the EURELD survey instrument. SUBJECTS: All 1645
      physician members of the German Society for Palliative Medicine. Main outcome
      measures Types and frequencies of limitation of treatment and possible
      determinants. RESULTS: 901 physicians participated in the study (response rate
      55.8%). Participants reported limitation of treatment in 69.1% of cases. These
      decisions most often affected artificial nutrition (19%), chemotherapy (14%),
      antibiotics (11%) and medication other than antibiotics (11%). In the majority of
      eligible cases, physicians estimated the life-shortening effect of limitation of 
      treatment to be <7 days. However, estimations differ depending on the medical
      measures in question. Bivariate statistical analysis indicated that withholding
      of treatment was performed significantly more frequently for patients aged >/=65 
      years (p=0.019). In addition, there were significant associations between the
      incidence of limitation of treatment and the different diseases reported by
      respondents as the underlying cause of death. CONCLUSION: The findings of this
      study provide information on the current state of an ethically and clinically
      challenging aspect of clinical practice and can serve as a starting point for
      further interdisciplinary research on normative and empirical aspects of
      treatment decision-making at the end of life.
FAU - Schildmann, Jan
AU  - Schildmann J
AD  - Institut fur Medizinische Ethik und Geschichte der Medizin and History of
      Medicine, Ruhr-Universitaet Bochum, Malakowturm-Markstrasse 258a, Bochum,
      Germany. jan.schildmann@rub.de
FAU - Hoetzel, Julia
AU  - Hoetzel J
FAU - Baumann, Anne
AU  - Baumann A
FAU - Mueller-Busch, Christof
AU  - Mueller-Busch C
FAU - Vollmann, Jochen
AU  - Vollmann J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110202
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Decision Making/*ethics
MH  - Female
MH  - Germany
MH  - Humans
MH  - Infant
MH  - Male
MH  - Middle Aged
MH  - Palliative Care/*ethics
MH  - Patient Selection/*ethics
MH  - Physicians/ethics/*psychology
MH  - Surveys and Questionnaires
MH  - Terminal Care/*ethics
MH  - Young Adult
EDAT- 2011/02/05 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/02/05 06:00
PHST- 2011/02/05 06:00 [entrez]
PHST- 2011/02/05 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - jme.2010.039248 [pii]
AID - 10.1136/jme.2010.039248 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Jun;37(6):327-32. doi: 10.1136/jme.2010.039248. Epub 2011 Feb 
      2.


PMID- 21292696
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20110524
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 6
DP  - 2011 Jun
TI  - The limits of empathy: problems in medical education and practice.
PG  - 380-3
LID - 10.1136/jme.2010.039628 [doi]
AB  - Empathy is commonly regarded as an essential attribute for doctors and there is a
      conviction that empathy must be taught to medical students. Yet it is not clear
      exactly what empathy is, from a philosophical or sociological point of view, or
      whether it can be taught. The meaning, role and relevance of empathy in medical
      education have tended to be unquestioningly assumed; there is a need to examine
      and contextualise these assumptions. This paper opens up that debate, arguing
      that 'empathy', as it is commonly understood, is neither necessary nor sufficient
      to guarantee good medical or ethical practice.
FAU - Smajdor, Anna
AU  - Smajdor A
AD  - School of Medicine, Health Policy and Practice, University of East Anglia,
      Norwich, UK. a.smajdor@uea.ac.uk
FAU - Stockl, Andrea
AU  - Stockl A
FAU - Salter, Charlotte
AU  - Salter C
LA  - eng
PT  - Journal Article
DEP - 20110202
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Clinical Competence/*standards
MH  - *Curriculum
MH  - Education, Medical/*methods
MH  - *Empathy
MH  - Female
MH  - Humans
MH  - Male
MH  - Physician-Patient Relations
MH  - Physicians/*psychology
MH  - Students, Medical/*psychology
EDAT- 2011/02/05 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/02/05 06:00
PHST- 2011/02/05 06:00 [entrez]
PHST- 2011/02/05 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - jme.2010.039628 [pii]
AID - 10.1136/jme.2010.039628 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Jun;37(6):380-3. doi: 10.1136/jme.2010.039628. Epub 2011 Feb
      2.


PMID- 21292695
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20110421
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 5
DP  - 2011 May
TI  - The ideal application of surveillance technology in residential care for people
      with dementia.
PG  - 303-10
LID - 10.1136/jme.2010.040774 [doi]
AB  - BACKGROUND: As our society is ageing, nursing homes are finding it increasingly
      difficult to deal with an expanding population of patients with dementia and a
      decreasing workforce. A potential answer to this problem might lie in the use of 
      technology. However, the use and application of surveillance technology in
      dementia care has led to considerable ethical debate among healthcare
      professionals and ethicists, with no clear consensus to date. AIM: To explore how
      surveillance technology is viewed by care professionals and ethicists working in 
      the field, by investigating the ideal application of surveillance technology in
      the residential care of people with dementia. METHODS: Use was made of the
      concept mapping method, a computer-assisted procedure consisting of five steps:
      brainstorming, prioritizing, clustering, processing by the computer and analysis.
      Various participants (ranging from ethicists to physicians and nurses) were
      invited on the basis of their professional background. RESULTS: The views
      generated are grouped into six categories ranging from the need for a right
      balance between freedom and security, to be beneficial and tailored to the
      resident, and clearly defined procedures to competent and caring personnel,
      active monitoring and clear normative guidance. The results are presented in the 
      form of a graphic chart. CONCLUSIONS: There appears to be an inherent duality in 
      the views on using surveillance technology which is rooted in the moral conflict 
      between safety and freedom. Elaboration of this ethical issue has proved to be
      very difficult.
FAU - Niemeijer, Alistair R
AU  - Niemeijer AR
AD  - Department of Nursing Home Medicine, EMGO Institute for Health and Care Research,
      VU University Medical Center, Amsterdam, The Netherlands. a.niemeijer@vumc.nl
FAU - Frederiks, Brenda J M
AU  - Frederiks BJ
FAU - Depla, Marja F I A
AU  - Depla MF
FAU - Legemaate, Johan
AU  - Legemaate J
FAU - Eefsting, Jan A
AU  - Eefsting JA
FAU - Hertogh, Cees M P M
AU  - Hertogh CM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110202
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Delivery of Health Care/*ethics/standards
MH  - Dementia/*psychology
MH  - Humans
MH  - Privacy/*psychology
MH  - Safety Management/*ethics/standards
MH  - Technology/*ethics/standards
EDAT- 2011/02/05 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/02/05 06:00
PHST- 2011/02/05 06:00 [entrez]
PHST- 2011/02/05 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - jme.2010.040774 [pii]
AID - 10.1136/jme.2010.040774 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 May;37(5):303-10. doi: 10.1136/jme.2010.040774. Epub 2011 Feb 
      2.


PMID- 21292694
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20110524
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 6
DP  - 2011 Jun
TI  - To lie or not to lie: resident physician attitudes about the use of deception in 
      clinical practice.
PG  - 333-8
LID - 10.1136/jme.2010.040683 [doi]
AB  - BACKGROUND: Physicians face competing values of truth-telling and beneficence
      when deception may be employed in patient care. The purposes of this study were
      to assess resident physicians' attitudes towards lying, explore lie types and
      reported reasons for lying. METHOD: After obtaining institutional review board
      review (OSR# 58013) and receiving exempt status, posts written by Loma Linda
      University resident physicians in response to forum questions in required online 
      courses were collected from 2002 to 2007. Responses were blinded and manually
      coded by two investigators using NVivo software. Qualitative and quantitative
      analyses of the data were performed with links to various attributes. A 95%
      binomial proportion CI was used to analyse the attribute data. RESULTS: The study
      found that the majority of residents (90.3%) would disclose the truth about
      medical errors. Similarly, many residents (55.7%) would disclose the truth
      regarding unanticipated events, especially if the error was serious enough to
      result in a malpractice suit (74.7%). However, many residents (40.9%) would not
      reveal a near miss event because they believe it has no impact on patient health.
      Some residents (47.3%) would deceive the insurance company for additional patient
      benefits. Of those willing to lie, only a small group (4.2%) gave self-serving
      reasons. CONCLUSIONS: This study demonstrates that the ethical issues related to 
      deception that trouble attending physicians also exist at the resident physician 
      level. Residents primarily lie for altruistic reasons and rarely for egoistic or 
      self-serving purposes that may or may not result in harm to patients, insurance
      companies and/or physicians themselves.
FAU - Everett, Jo P
AU  - Everett JP
AD  - Chan Shun Pavilion, 11175 Campus Street, Loma Linda, CA 92350 USA.
      joeverett7@gmail.com
FAU - Walters, Clifford A
AU  - Walters CA
FAU - Stottlemyer, Debra L
AU  - Stottlemyer DL
FAU - Knight, Curtis A
AU  - Knight CA
FAU - Oppenberg, Andrew A
AU  - Oppenberg AA
FAU - Orr, Robert D
AU  - Orr RD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110202
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Attitude of Health Personnel
MH  - *Deception
MH  - Female
MH  - Humans
MH  - Insurance, Health, Reimbursement
MH  - Male
MH  - Physician-Patient Relations/*ethics
MH  - Physicians/*ethics
MH  - Truth Disclosure/*ethics
EDAT- 2011/02/05 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/02/05 06:00
PHST- 2011/02/05 06:00 [entrez]
PHST- 2011/02/05 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - jme.2010.040683 [pii]
AID - 10.1136/jme.2010.040683 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Jun;37(6):333-8. doi: 10.1136/jme.2010.040683. Epub 2011 Feb
      2.


PMID- 21292065
OWN - NLM
STAT- MEDLINE
DCOM- 20110803
LR  - 20141120
IS  - 1531-5037 (Electronic)
IS  - 0022-3468 (Linking)
VI  - 46
IP  - 2
DP  - 2011 Feb
TI  - Terlipressin as rescue therapy for refractory pulmonary hypertension in a neonate
      with a congenital diaphragmatic hernia.
PG  - e19-21
LID - 10.1016/j.jpedsurg.2010.10.006 [doi]
AB  - We report the case of a 38-week gestational age neonate, with isolated congenital
      diaphragmatic hernia presenting with refractory persistent pulmonary
      hypertension, systemic hypotension, and hypoxemia, resistant to usual
      therapeutics. Arginine vasopressin is responsible for systemic vasoconstriction
      and decreases pulmonary hypertension. We theorized that terlipressin, its
      long-acting analogue, could have the same properties. We used terlipressin as
      rescue therapy after parental and local ethics committee acceptance. After a
      bolus of terlipressin 20 mug/kg and continuous infusion at a rate of 5 mug/kg per
      hour, blood oxygen saturation improved from 75% to 98%, oxygen requirements fell 
      from fraction of inspired oxygen 100% to 40%, and mean arterial pressure rose
      from 28 to 46 mm Hg, allowing a decrease of vasopressor infusion. Terlipressin
      may be useful in the management of neonates with congenital diaphragmatic hernia 
      and refractory pulmonary hypertension.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Stathopoulos, Lefteris
AU  - Stathopoulos L
AD  - Reanimation Pediatrique et Neonatale, Brules Pediatriques, Pole RAUC, Centre
      Hospitalo-Universitaire Nord, Marseille, France.
FAU - Nicaise, Claire
AU  - Nicaise C
FAU - Michel, Fabrice
AU  - Michel F
FAU - Thomachot, Laurent
AU  - Thomachot L
FAU - Merrot, Thierry
AU  - Merrot T
FAU - Lagier, Pierre
AU  - Lagier P
FAU - Martin, Claude
AU  - Martin C
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Pediatr Surg
JT  - Journal of pediatric surgery
JID - 0052631
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Vasoconstrictor Agents)
SB  - IM
MH  - Antihypertensive Agents/administration & dosage/*therapeutic use
MH  - Cause of Death
MH  - Delayed-Action Preparations
MH  - Drug Resistance
MH  - Fatal Outcome
MH  - Hernia, Diaphragmatic/complications
MH  - Hernias, Diaphragmatic, Congenital
MH  - Humans
MH  - Hypertension, Pulmonary/complications/*drug therapy
MH  - Infant, Newborn
MH  - Infusions, Intravenous
MH  - Intensive Care Units, Neonatal
MH  - Male
MH  - Shock, Septic/mortality
MH  - Treatment Outcome
MH  - Vasoconstrictor Agents/administration & dosage/therapeutic use
EDAT- 2011/02/05 06:00
MHDA- 2011/08/04 06:00
CRDT- 2011/02/05 06:00
PHST- 2010/07/27 00:00 [received]
PHST- 2010/09/29 00:00 [revised]
PHST- 2010/10/04 00:00 [accepted]
PHST- 2011/02/05 06:00 [entrez]
PHST- 2011/02/05 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
AID - S0022-3468(10)00932-2 [pii]
AID - 10.1016/j.jpedsurg.2010.10.006 [doi]
PST - ppublish
SO  - J Pediatr Surg. 2011 Feb;46(2):e19-21. doi: 10.1016/j.jpedsurg.2010.10.006.


PMID- 21288228
OWN - NLM
STAT- MEDLINE
DCOM- 20110701
LR  - 20181201
IS  - 1399-6576 (Electronic)
IS  - 0001-5172 (Linking)
VI  - 55
IP  - 4
DP  - 2011 Apr
TI  - Timing of intravenous patient-controlled remifentanil bolus during early labour.
PG  - 486-94
LID - 10.1111/j.1399-6576.2010.02390.x [doi]
AB  - BACKGROUND: Remifentanil labour analgesia is superior to nitrous oxide but less
      potent than epidural analgesia. The short onset and offset times of effect
      suggest that the timing of the bolus in the contraction cycle could have
      importance. We hypothesised that administering a remifentanil bolus during
      contraction pause would improve analgesia in early labour. METHODS: With
      permission from the ethical committee and the National Authority of Medicines, 50
      parturients with uncomplicated singleton pregnancies and informed consent
      participated in a double blind cross-over study. Intravenous doses of 0.4 mug/kg 
      remifentanil with 1-min infusion times were used during two study periods lasting
      six to eight contractions. Remifentanil and saline syringes were attached to two 
      patient-controlled devices, one of which administered the bolus immediately after
      a trigger and the other targeted to start 140 s before the next contraction. The 
      parturients assessed contraction pain, pain relief, sedation and nausea. Oxygen
      saturation (SaO(2)) pulse and blood pressure were recorded. SaO(2)<95% was the
      indication for oxygen supplement. RESULTS: Forty-one parturients were included in
      the analyses. Because of the period effect, pain and pain relief scores were
      analysed separately for each of the study periods. The mean pain and pain relief 
      scores were similar during the two different dosing regimens. Side effects, the
      need for supplemental oxygen, SaO(2) and haemodynamics were similar. In a
      subgroup with long and regular contractions, however, delayed boluses were
      associated with lower pain scores. CONCLUSIONS: Administering a remifentanil
      bolus during the uterine contraction pause does not improve pain relief.
CI  - (c) 2011 The Authors. Acta Anaesthesiologica Scandinavica (c) 2011 The Acta
      Anaesthesiologica Scandinavica Foundation.
FAU - Volmanen, P V E
AU  - Volmanen PV
AD  - Lapland Central Hospital, Rovaniemi, Finland. petri.volmanen@isshp.fi
FAU - Akural, E I
AU  - Akural EI
FAU - Raudaskoski, T
AU  - Raudaskoski T
FAU - Ranta, P
AU  - Ranta P
FAU - Tekay, A
AU  - Tekay A
FAU - Ohtonen, P
AU  - Ohtonen P
FAU - Alahuhta, S
AU  - Alahuhta S
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20110202
PL  - England
TA  - Acta Anaesthesiol Scand
JT  - Acta anaesthesiologica Scandinavica
JID - 0370270
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Hemoglobins)
RN  - 0 (Piperidines)
RN  - P10582JYYK (Remifentanil)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Analgesia, Obstetrical/*methods
MH  - *Analgesia, Patient-Controlled
MH  - Analgesics, Opioid/*administration & dosage/*therapeutic use
MH  - Apgar Score
MH  - Cross-Over Studies
MH  - Data Interpretation, Statistical
MH  - Double-Blind Method
MH  - Female
MH  - Heart Rate/drug effects
MH  - Heart Rate, Fetal/drug effects
MH  - Hemoglobins/metabolism
MH  - Humans
MH  - Infusion Pumps
MH  - Infusions, Intravenous
MH  - Middle Aged
MH  - Oxygen/blood
MH  - Pain Measurement
MH  - Piperidines/*administration & dosage/*therapeutic use
MH  - Pregnancy
MH  - Remifentanil
MH  - Uterine Contraction
MH  - Young Adult
EDAT- 2011/02/04 06:00
MHDA- 2011/07/02 06:00
CRDT- 2011/02/04 06:00
PHST- 2011/02/04 06:00 [entrez]
PHST- 2011/02/04 06:00 [pubmed]
PHST- 2011/07/02 06:00 [medline]
AID - 10.1111/j.1399-6576.2010.02390.x [doi]
PST - ppublish
SO  - Acta Anaesthesiol Scand. 2011 Apr;55(4):486-94. doi:
      10.1111/j.1399-6576.2010.02390.x. Epub 2011 Feb 2.


PMID- 21287413
OWN - NLM
STAT- MEDLINE
DCOM- 20110524
LR  - 20110202
IS  - 1545-5815 (Electronic)
IS  - 0898-9621 (Linking)
VI  - 18
IP  - 1
DP  - 2011 Jan
TI  - Bad news about bad news: the disclosure of risks to insurability in research
      consent processes.
PG  - 31-44
LID - 10.1080/08989621.2011.542681 [doi]
AB  - One of the phenomena associated with research is "incidental findings," that is, 
      unexpected findings made during the research, and outside the scope of the
      research, which have potential health importance. One underappreciated risk of
      incidental findings is the potential loss of the research subject's insurability;
      or if a research subject fails to disclose incidental findings when applying for 
      insurance, the insurance contract may be voidable by the insurer. In this
      article, we seek to explain the insurability risks associated with incidental
      findings and to make recommendations for how researchers and research ethics
      committees should address the issue of disclosure of these risks.
FAU - Apold, Victoria Smith
AU  - Apold VS
AD  - Faculties of Law and Medicine, Dalhousie University, Halifax, Nova Scotia,
      Canada.
FAU - Downie, Jocelyn
AU  - Downie J
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Account Res
JT  - Accountability in research
JID - 9100813
SB  - IM
MH  - Canada
MH  - Ethics, Research
MH  - Humans
MH  - *Incidental Findings
MH  - Informed Consent/*ethics/legislation & jurisprudence
MH  - Insurance Coverage/*ethics/legislation & jurisprudence
MH  - Insurance Selection Bias
MH  - Insurance, Life/*ethics/legislation & jurisprudence
MH  - Research Subjects
MH  - *Risk
MH  - Truth Disclosure/*ethics
EDAT- 2011/02/03 06:00
MHDA- 2011/05/25 06:00
CRDT- 2011/02/03 06:00
PHST- 2011/02/03 06:00 [entrez]
PHST- 2011/02/03 06:00 [pubmed]
PHST- 2011/05/25 06:00 [medline]
AID - 932984485 [pii]
AID - 10.1080/08989621.2011.542681 [doi]
PST - ppublish
SO  - Account Res. 2011 Jan;18(1):31-44. doi: 10.1080/08989621.2011.542681.


PMID- 21287145
OWN - NLM
STAT- MEDLINE
DCOM- 20110712
LR  - 20211020
IS  - 1432-1238 (Electronic)
IS  - 0342-4642 (Linking)
VI  - 37
IP  - 3
DP  - 2011 Mar
TI  - A national survey of Italian physicians' attitudes towards end-of-life decisions 
      following the death of Eluana Englaro.
PG  - 542-9
LID - 10.1007/s00134-011-2132-5 [doi]
AB  - BACKGROUND: Ethical issues regarding patient care have recently been raised in
      Italy by the case of Eluana Englaro, a 36-year-old woman who remained in a
      persistent vegetative state (PVS) for 17 years. There are no specific laws on the
      books in Italy regarding euthanasia and physician-assisted suicide. In November
      2008, a controversial decision by the Italian Supreme Court granted the woman's
      father his wish to discontinue nutrition and hydration provided to her. Because
      of this historic decision, the authors carried out a survey of Italian
      physicians' beliefs regarding end-of-life practices. METHODS: A questionnaire was
      e-mailed to 70,000 physicians working for the Italian Public Health System and
      University Medical Hospitals. RESULTS: A total of 22,219 doctors responded to the
      questionnaire (32.3%), of whom 17,252 (77.6%) had some experience in treating PVS
      patients. Nearly 70% of responding doctors were aware of PVS diagnostic criteria;
      most of them (61%) considered tube feeding to be a medical therapy, and 66% of
      respondents believed that withdrawal of assisted nutrition and hydration (ANH)
      might be appropriate depending on the patient's wishes. Moreover, even though 50%
      of doctors surveyed were not in favor of euthanasia, a significant percentage
      (42%) did approve of it, while 8% of this sample was uncertain. CONCLUSIONS:
      Italian doctors probably have the least experience in end-of-life decisions in
      Europe, therefore this national survey is a great chance to understand their
      authentic opinions regarding such remarkable issues. There is broad consensus
      that a clear legislative position regarding euthanasia and ANH is needed.
FAU - Solarino, Biagio
AU  - Solarino B
AD  - Section of Legal Medicine, Department of Internal Medicine and Public Medicine,
      University of Bari, Bari, Italy. bisola@tin.it
FAU - Bruno, Francesco
AU  - Bruno F
FAU - Frati, Giacomo
AU  - Frati G
FAU - Dell'erba, Alessandro
AU  - Dell'erba A
FAU - Frati, Paola
AU  - Frati P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110202
PL  - United States
TA  - Intensive Care Med
JT  - Intensive care medicine
JID - 7704851
SB  - IM
MH  - Adult
MH  - Advance Directives
MH  - Aged
MH  - *Attitude of Health Personnel
MH  - Decision Making/*ethics
MH  - *Euthanasia, Passive/ethics/legislation & jurisprudence
MH  - Female
MH  - Health Care Surveys
MH  - Humans
MH  - Italy
MH  - Male
MH  - Middle Aged
MH  - Persistent Vegetative State
MH  - Physician's Role
MH  - Physicians/*psychology
MH  - Terminal Care/*ethics/legislation & jurisprudence
EDAT- 2011/02/03 06:00
MHDA- 2011/07/13 06:00
CRDT- 2011/02/03 06:00
PHST- 2010/03/31 00:00 [received]
PHST- 2010/12/03 00:00 [accepted]
PHST- 2011/02/03 06:00 [entrez]
PHST- 2011/02/03 06:00 [pubmed]
PHST- 2011/07/13 06:00 [medline]
AID - 10.1007/s00134-011-2132-5 [doi]
PST - ppublish
SO  - Intensive Care Med. 2011 Mar;37(3):542-9. doi: 10.1007/s00134-011-2132-5. Epub
      2011 Feb 2.


PMID- 21285427
OWN - NLM
STAT- MEDLINE
DCOM- 20110214
LR  - 20161017
IS  - 1538-3598 (Electronic)
IS  - 0098-7484 (Linking)
VI  - 305
IP  - 5
DP  - 2011 Feb 2
TI  - Clinician integrity and limits to patient autonomy.
PG  - 495-9
LID - 10.1001/jama.2011.32 [doi]
AB  - A 28-year-old man with chronic granulomatous disease developed worsening
      respiratory status in the setting of chronic bacterial and fungal infections. The
      attending physician recommended transfer to the intensive care unit (ICU), but
      the patient declined. The patient understood that the nurses in the ICU have
      expertise in caring for patients with poor respiratory function. He also
      understood that he faced an increased risk of dying if he remained on the medical
      ward. At the same time, the patient was familiar with the nurses on the medical
      ward and felt comfortable there. Unsure of whether it was appropriate for
      clinicians to agree to provide less than optimal care for a critically ill
      patient, the clinicians on the medical ward requested a bioethics consultation.
      This article reviews the ethical issues that arise when patients ask clinicians
      to provide less than optimal care. Although it is well established that
      clinicians ought to respect patient autonomy, that obligation conflicted, in the 
      present case, with the clinicians' sense of professional integrity. Future
      research on this vital but underexplored topic is needed to determine the extent 
      to which clinicians' professional integrity places limits on the types of patient
      requests to which they should agree.
FAU - Lantos, John
AU  - Lantos J
AD  - Children's Mercy Bioethics Center, Children's Mercy Hospital, 2401 Gilham Rd,
      Kansas City, MO 64108, USA. jlantos@cmh.edu
FAU - Matlock, Ann Marie
AU  - Matlock AM
FAU - Wendler, David
AU  - Wendler D
LA  - eng
PT  - Case Reports
PT  - Clinical Conference
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - JAMA
JT  - JAMA
JID - 7501160
SB  - IM
CIN - JAMA. 2011 May 11;305(18):1861; author reply 1861-2. PMID: 21558516
MH  - Adult
MH  - Bacterial Infections/physiopathology
MH  - Clinical Competence
MH  - *Ethics Consultation
MH  - Ethics, Medical
MH  - Granulomatous Disease, Chronic/complications/physiopathology
MH  - Humans
MH  - *Intensive Care Units
MH  - Lung/physiopathology
MH  - Lung Diseases, Fungal/physiopathology
MH  - Male
MH  - Patient Transfer/ethics
MH  - *Personal Autonomy
MH  - *Physician's Role
MH  - Treatment Refusal/*ethics
EDAT- 2011/02/03 06:00
MHDA- 2011/02/15 06:00
CRDT- 2011/02/03 06:00
PHST- 2011/02/03 06:00 [entrez]
PHST- 2011/02/03 06:00 [pubmed]
PHST- 2011/02/15 06:00 [medline]
AID - 305/5/495 [pii]
AID - 10.1001/jama.2011.32 [doi]
PST - ppublish
SO  - JAMA. 2011 Feb 2;305(5):495-9. doi: 10.1001/jama.2011.32.


PMID- 21285303
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20161020
IS  - 1526-3347 (Electronic)
IS  - 0191-9601 (Linking)
VI  - 32
IP  - 2
DP  - 2011 Feb
TI  - Ethical issues in organ donation.
PG  - 69-72
LID - 10.1542/pir.32-2-69 [doi]
FAU - Macauley, Robert
AU  - Macauley R
AD  - University of Vermont College of Medicine, Burlington, VT, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pediatr Rev
JT  - Pediatrics in review
JID - 8103046
SB  - IM
MH  - Cadaver
MH  - Child
MH  - Hematopoietic Stem Cell Transplantation/ethics
MH  - Humans
MH  - Living Donors/ethics
MH  - Organ Transplantation/ethics
MH  - Tissue and Organ Harvesting/*ethics
MH  - Tissue and Organ Procurement/*ethics
EDAT- 2011/02/03 06:00
MHDA- 2011/06/03 06:00
CRDT- 2011/02/03 06:00
PHST- 2011/02/03 06:00 [entrez]
PHST- 2011/02/03 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
AID - 32/2/69 [pii]
AID - 10.1542/pir.32-2-69 [doi]
PST - ppublish
SO  - Pediatr Rev. 2011 Feb;32(2):69-72. doi: 10.1542/pir.32-2-69.


PMID- 21285206
OWN - NLM
STAT- MEDLINE
DCOM- 20110603
LR  - 20181201
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 1
DP  - 2011 Jan
TI  - Report: 11th International ICNE conference: Clinical ethics across the lifespan, 
      13-14 September 2010.
PG  - 131-2
LID - 10.1177/0969733010388104 [doi]
FAU - Suhonen, Riitta
AU  - Suhonen R
AD  - University of Turku, Department of Nursing Science, Lemminkaisenkatu 1, 2 krs,
      20014 Turku, Finland. riisuh@utu.fi
LA  - eng
PT  - Congress
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - *Ethics, Clinical
MH  - *Ethics, Nursing
MH  - Human Rights
MH  - Humans
MH  - International Cooperation
MH  - Patient Rights/*ethics
MH  - *Philosophy, Nursing
EDAT- 2011/02/03 06:00
MHDA- 2011/06/04 06:00
CRDT- 2011/02/03 06:00
PHST- 2011/02/03 06:00 [entrez]
PHST- 2011/02/03 06:00 [pubmed]
PHST- 2011/06/04 06:00 [medline]
AID - 18/1/131 [pii]
AID - 10.1177/0969733010388104 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Jan;18(1):131-2. doi: 10.1177/0969733010388104.


PMID- 21285203
OWN - NLM
STAT- MEDLINE
DCOM- 20110603
LR  - 20161125
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 1
DP  - 2011 Jan
TI  - Is it appropriate for research ethics committees to make judgements about the
      scientific quality of research proposals?.
PG  - 122-5
LID - 10.1177/0969733010387051 [doi]
FAU - Brecher, Bob
AU  - Brecher B
AD  - University of Brighton, UK.
FAU - Gardener, Guy
AU  - Gardener G
FAU - Velepic, Marina
AU  - Velepic M
FAU - Walsh, Aileen
AU  - Walsh A
FAU - Belshaw, Christopher
AU  - Belshaw C
FAU - Holland, Stephen
AU  - Holland S
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - *Ethical Review
MH  - Ethics Committees, Research/*organization & administration
MH  - *Ethics, Nursing
MH  - Health Knowledge, Attitudes, Practice
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Personal Autonomy
MH  - Research Design
MH  - Slovenia
MH  - United Kingdom
EDAT- 2011/02/03 06:00
MHDA- 2011/06/04 06:00
CRDT- 2011/02/03 06:00
PHST- 2011/02/03 06:00 [entrez]
PHST- 2011/02/03 06:00 [pubmed]
PHST- 2011/06/04 06:00 [medline]
AID - 18/1/122 [pii]
AID - 10.1177/0969733010387051 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Jan;18(1):122-5. doi: 10.1177/0969733010387051.


PMID- 21285202
OWN - NLM
STAT- MEDLINE
DCOM- 20110603
LR  - 20151119
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 1
DP  - 2011 Jan
TI  - An embodied response: ethics and the nurse researcher.
PG  - 112-21
LID - 10.1177/0969733010385531 [doi]
AB  - The aim of this study is to reflect on situational ethics in qualitative research
      and on a researcher's embodied response to ethical dilemmas. Four narratives are 
      presented. They are excerpts from field notes taken during an observational study
      on Norwegian public health nursing practice. The stories capture situational
      ethical challenges the author experienced during her research. The author's
      reflections on feelings of uncertainty, discomfort and responsibility, and
      Levinas' philosophy help to illuminate the ethical challenges faced. The study
      shows that the researcher always participates, to some degree, and is never
      merely a spectator making solely rational choices. Ethical challenges in field
      research cannot always be solved, yet must be acknowledged. Feelings of
      vulnerability are embodied responses that remind us of the primacy of ethics.
      More so, it is the primacy of ethics that gives rise to feelings of vulnerability
      and embodied responses.
FAU - Clancy, Anne
AU  - Clancy A
AD  - Harstad University College, Norway. anne.clancy@hih.no
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - *Ethics, Nursing
MH  - Humans
MH  - Job Satisfaction
MH  - Moral Obligations
MH  - Norway
MH  - *Nurse's Role
MH  - Nurse-Patient Relations/ethics
MH  - Nursing Methodology Research/*ethics
MH  - Nursing Theory
MH  - *Philosophy, Nursing
MH  - Public Health Nursing/*ethics
MH  - Research Design
MH  - Research Personnel/*ethics
MH  - Research Subjects/psychology
MH  - Researcher-Subject Relations/ethics
MH  - Surveys and Questionnaires
MH  - Vulnerable Populations/psychology
EDAT- 2011/02/03 06:00
MHDA- 2011/06/04 06:00
CRDT- 2011/02/03 06:00
PHST- 2011/02/03 06:00 [entrez]
PHST- 2011/02/03 06:00 [pubmed]
PHST- 2011/06/04 06:00 [medline]
AID - 18/1/112 [pii]
AID - 10.1177/0969733010385531 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Jan;18(1):112-21. doi: 10.1177/0969733010385531.


PMID- 21285200
OWN - NLM
STAT- MEDLINE
DCOM- 20110603
LR  - 20110202
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 1
DP  - 2011 Jan
TI  - Theory of protective empowering for balancing patient safety and choices.
PG  - 88-101
LID - 10.1177/0969733010386169 [doi]
AB  - Registered nurses in psychiatric-mental health nursing continuously balance the
      ethical principles of duty to do good (beneficence) and no harm (non-maleficence)
      with the duty to respect patient choices (autonomy). However, the problem of
      nurses' level of control versus patients' choices remains a challenge. The aim of
      this article is to discuss how nurses accomplish their simultaneous
      responsibility for balancing patient safety (beneficence and non-maleficence)
      with patient choices (autonomy) through the theory of protective empowering. This
      is done by reflecting on interview excerpts about caring from 17 registered
      nurses taking part in a grounded theory study conducted in three acute urban
      psychiatric hospital settings in Canada. The interplay between the protective and
      empowering dimensions of the theory of protective empowering was found to
      correspond with international, national, and local nursing codes of ethics and
      standards. The overall core process of protective empowering, and its associated 
      reflective questions, is offered as a new lens for balancing patient safety with 
      choices.
FAU - Chiovitti, Rosalina F
AU  - Chiovitti RF
AD  - School of Health Sciences, University of New Brunswick-Humber Bachelor of Nursing
      Program, Humber College Institute of Technology and Advanced Learning, 205 Humber
      College Boulevard, Toronto, ON, Canada M9W 5L7. rosalina.chiovitti@humber.ca
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - *Ethics, Nursing
MH  - Humans
MH  - Interprofessional Relations
MH  - Mental Disorders/nursing
MH  - Mentally Ill Persons
MH  - *Nurse's Role
MH  - Nurse-Patient Relations/*ethics
MH  - Nursing Methodology Research
MH  - Nursing Staff/*ethics
MH  - *Nursing Theory
MH  - Ontario
MH  - Psychiatric Nursing/*ethics
MH  - Quality of Health Care/ethics
MH  - *Safety
EDAT- 2011/02/03 06:00
MHDA- 2011/06/04 06:00
CRDT- 2011/02/03 06:00
PHST- 2011/02/03 06:00 [entrez]
PHST- 2011/02/03 06:00 [pubmed]
PHST- 2011/06/04 06:00 [medline]
AID - 18/1/88 [pii]
AID - 10.1177/0969733010386169 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Jan;18(1):88-101. doi: 10.1177/0969733010386169.


PMID- 21285199
OWN - NLM
STAT- MEDLINE
DCOM- 20110603
LR  - 20161125
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 1
DP  - 2011 Jan
TI  - Can supervising self-harm be part of ethical nursing practice?
PG  - 79-87
LID - 10.1177/0969733010386166 [doi]
AB  - It was reported in 2006 that a regime of 'supervised self harm' had been
      implemented at St George's Hospital, Stafford. This involves patients with a
      history of self-harming behaviour being offered both emotional and practical
      support to enable them to do so. This support can extend to the provision of
      knives or razors to enable them to self-harm while they are being supervised by a
      nurse. This article discusses, and evaluates from an ethical perspective, three
      competing responses to self-harming behaviours: to prevent it; to allow it; and
      to make provision for supervised self-harm. It is argued that of these three
      options the prevention strategy is the least plausible. A tentative conclusion is
      offered in support of supervised self-harm.
FAU - Edwards, Steven D
AU  - Edwards SD
AD  - Department of Philosophy, History and Law, School of Health and Human Sciences,
      Swansea University, UK. s.d.edwards@swansea.ac.uk
FAU - Hewitt, Jeanette
AU  - Hewitt J
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - *Ethics, Nursing
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - *Nurse's Role
MH  - Nurse-Patient Relations/*ethics
MH  - Nursing Assessment
MH  - Psychiatric Nursing/*ethics
MH  - Self-Injurious Behavior/*nursing/psychology
MH  - United Kingdom
EDAT- 2011/02/03 06:00
MHDA- 2011/06/04 06:00
CRDT- 2011/02/03 06:00
PHST- 2011/02/03 06:00 [entrez]
PHST- 2011/02/03 06:00 [pubmed]
PHST- 2011/06/04 06:00 [medline]
AID - 18/1/79 [pii]
AID - 10.1177/0969733010386166 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Jan;18(1):79-87. doi: 10.1177/0969733010386166.


PMID- 21285198
OWN - NLM
STAT- MEDLINE
DCOM- 20110603
LR  - 20151119
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 1
DP  - 2011 Jan
TI  - Violation of ethical principles in institutional care for older people.
PG  - 64-78
LID - 10.1177/0969733010385529 [doi]
AB  - This study focuses on issues of elder abuse in residential settings. Violation of
      ethical principles is shown in the results of this quantitative study aimed at
      defining the extent, nature and causes of such abuse by employees' unethical
      conduct towards clients in senior homes (i.e. residential nursing homes) in the
      Moravian-Silesian region of the Czech Republic. The research sample comprised 454
      employees and 488 clients from 12 residential homes for older people. The data
      were collected from interviews with clients, who also received a questionnaire
      concerning their satisfaction with the institution. Two questionnaires were
      administered to the employees, one based on a pilot qualitative study and a
      second to investigate burnout. Outcomes were assessed according to the extent and
      form of elder abuse, the causes of elder abuse and the violation of basic ethical
      principles. The responses, in particular those of employees, revealed both
      psychological and physical abuse of older clients, and thus violation of two
      basic principles: respect for the person and non-maleficence. The group at risk
      of elder abuse comprised aggressive and dissatisfied clients, as well as those
      with mental problems and dementia. The employees most at risk of being abusers
      were those who had been employed in institutional care for more than five years, 
      had inadequate knowledge about social services and suffered from burnout. The
      prevention of elder abuse is recommended to be through education focused on
      ethical principles, increasing employees' satisfaction by promoting a friendly
      and safe organizational culture, and providing adequate working conditions.
FAU - Buzgova, Radka
AU  - Buzgova R
AD  - Department of Nursing and Midwifery, Faculty of Health Studies, Ostrava
      University, Czech Republic. radka.buzgova@osu.cz
FAU - Ivanova, Katerina
AU  - Ivanova K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Burnout, Professional/*epidemiology/nursing
MH  - Czech Republic/epidemiology
MH  - Elder Abuse/*ethics/*statistics & numerical data
MH  - Ethics, Nursing
MH  - Female
MH  - Homes for the Aged/*ethics/organization & administration
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nursing Homes/*ethics/organization & administration
MH  - Nursing Staff/*ethics/statistics & numerical data
MH  - Pilot Projects
MH  - Risk Factors
MH  - Social Environment
MH  - Surveys and Questionnaires
EDAT- 2011/02/03 06:00
MHDA- 2011/06/04 06:00
CRDT- 2011/02/03 06:00
PHST- 2011/02/03 06:00 [entrez]
PHST- 2011/02/03 06:00 [pubmed]
PHST- 2011/06/04 06:00 [medline]
AID - 18/1/64 [pii]
AID - 10.1177/0969733010385529 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Jan;18(1):64-78. doi: 10.1177/0969733010385529.


PMID- 21285197
OWN - NLM
STAT- MEDLINE
DCOM- 20110603
LR  - 20110202
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 1
DP  - 2011 Jan
TI  - Being a good nurse and doing the right thing: a replication study.
PG  - 54-63
LID - 10.1177/0969733010386162 [doi]
AB  - This qualitative research study, a replication of a study published in 2002,
      investigated the qualities of a good nurse and the role ethics plays in decision 
      making. After reviewing the limitations of the published work, the current study 
      implemented modifications related to the research questions, sample selection,
      data collection, and use of software for data analysis. The original study
      identified seven categories that related to being a good nurse and doing the
      right thing. In the present study, the use of relational analysis led to the
      recognition of four categories: (1) personal traits and attributes; (2) technical
      skills and management of care; (3) work environment and co-workers; and (4)
      caring and caring behaviors. To understand what it means to be a good nurse and
      do the right thing is a complex task; however, this research adds to the small
      amount of empirical data that exists to describe those characteristics.
FAU - Catlett, Shelia
AU  - Catlett S
AD  - Western Kentucky University, Bowling Green, Kentucky 42101, USA.
FAU - Lovan, Sherry R
AU  - Lovan SR
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - *Ethics, Nursing
MH  - Humans
MH  - Job Satisfaction
MH  - *Nurse's Role
MH  - *Nurse-Patient Relations
MH  - Nursing Methodology Research
MH  - *Philosophy, Nursing
MH  - Social Perception
MH  - *Virtues
MH  - Workplace
EDAT- 2011/02/03 06:00
MHDA- 2011/06/04 06:00
CRDT- 2011/02/03 06:00
PHST- 2011/02/03 06:00 [entrez]
PHST- 2011/02/03 06:00 [pubmed]
PHST- 2011/06/04 06:00 [medline]
AID - 18/1/54 [pii]
AID - 10.1177/0969733010386162 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Jan;18(1):54-63. doi: 10.1177/0969733010386162.


PMID- 21285194
OWN - NLM
STAT- MEDLINE
DCOM- 20110603
LR  - 20110202
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 1
DP  - 2011 Jan
TI  - Relational and embodied knowing: nursing ethics within the interprofessional
      team.
PG  - 20-30
LID - 10.1177/0969733010386165 [doi]
AB  - In this article we attempt to situate nursing within the interprofessional care
      team with respect to processes of ethical practice and ethical decision making.
      After briefly reviewing the concept of interprofessionalism, the idea of a
      nursing ethic as 'unique' within the context of an interprofessional team will be
      explored. We suggest that nursing's distinct perspective on the moral matters of 
      health care stem not from any privileged vantage point but rather from knowledge 
      developed through the daily activities of nursing practice. Because of their
      position vis-a-vis patients and families in everyday clinical care, nurses
      cultivate ethical knowledge of at least two forms: (1) relational knowledge; and 
      (2) embodied knowledge. Through the integration of these forms of knowledge,
      nurses develop a unique moral perspective and can make a meaningful contribution 
      to the realm of ethics in interprofessional care.
FAU - Wright, David
AU  - Wright D
AD  - University of Ottawa School of Nursing, 451 Smyth Road, Ottawa, ON K1H 8M5,
      Canada. dwrig079@uottawa.ca
FAU - Brajtman, Susan
AU  - Brajtman S
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Burnout, Professional/prevention & control
MH  - *Ethics, Nursing
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - *Interprofessional Relations
MH  - Morals
MH  - *Nurse's Role
MH  - Patient Care Team/*ethics
MH  - Philosophy, Nursing
MH  - Professional Autonomy
MH  - Professional Competence
MH  - Social Values
EDAT- 2011/02/03 06:00
MHDA- 2011/06/04 06:00
CRDT- 2011/02/03 06:00
PHST- 2011/02/03 06:00 [entrez]
PHST- 2011/02/03 06:00 [pubmed]
PHST- 2011/06/04 06:00 [medline]
AID - 18/1/20 [pii]
AID - 10.1177/0969733010386165 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Jan;18(1):20-30. doi: 10.1177/0969733010386165.


PMID- 21285193
OWN - NLM
STAT- MEDLINE
DCOM- 20110603
LR  - 20151119
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 1
DP  - 2011 Jan
TI  - Clinical ethical conflicts of nurses and physicians.
PG  - 9-19
LID - 10.1177/0969733010385532 [doi]
AB  - Much of the literature on clinical ethical conflict has been specific to a
      specialty area or a particular patient group, as well as to a single profession. 
      This study identifies themes of hospital nurses' and physicians' clinical ethical
      conflicts that cut across the spectrum of clinical specialty areas, and compares 
      the themes identified by nurses with those identified by physicians. We
      interviewed 34 clinical nurses, 10 nurse managers and 31 physicians working at
      four different Canadian hospitals as part of a larger study on clinical ethics
      committees and nurses' and physicians' use of these committees. We describe nine 
      themes of clinical ethical conflict that were common to both hospital nurses and 
      physicians, and three themes that were specific to physicians. Following this, we
      suggest reasons for differences in nurses' and physicians' ethical conflicts and 
      discuss implications for practice and research.
FAU - Gaudine, Alice
AU  - Gaudine A
AD  - Memorial University of Newfoundland, St John's, Newfoundland, Canada.
FAU - LeFort, Sandra M
AU  - LeFort SM
FAU - Lamb, Marianne
AU  - Lamb M
FAU - Thorne, Linda
AU  - Thorne L
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Adult
MH  - Attitude of Health Personnel
MH  - Burnout, Professional/prevention & control
MH  - Canada
MH  - Ethics, Institutional
MH  - *Ethics, Nursing
MH  - Female
MH  - Humans
MH  - Male
MH  - Medical Staff, Hospital/*ethics
MH  - Middle Aged
MH  - Nursing Methodology Research
MH  - *Physician-Nurse Relations
MH  - Problem Solving/*ethics
MH  - Professional Autonomy
MH  - *Professional Competence
MH  - Surveys and Questionnaires
EDAT- 2011/02/03 06:00
MHDA- 2011/06/04 06:00
CRDT- 2011/02/03 06:00
PHST- 2011/02/03 06:00 [entrez]
PHST- 2011/02/03 06:00 [pubmed]
PHST- 2011/06/04 06:00 [medline]
AID - 18/1/9 [pii]
AID - 10.1177/0969733010385532 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Jan;18(1):9-19. doi: 10.1177/0969733010385532.


PMID- 21285192
OWN - NLM
STAT- MEDLINE
DCOM- 20110603
LR  - 20110202
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 1
DP  - 2011 Jan
TI  - Is there an Indian nursing ethics?
PG  - 6-8
LID - 10.1177/0969733010388105 [doi]
FAU - Furtado, Daphne Viveka
AU  - Furtado DV
LA  - eng
PT  - Editorial
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - *Cultural Characteristics
MH  - Education, Nursing/methods
MH  - *Ethics, Nursing
MH  - Holistic Health
MH  - Humans
MH  - India
MH  - *Nurse's Role
MH  - Nurse-Patient Relations
MH  - *Philosophy, Nursing
EDAT- 2011/02/03 06:00
MHDA- 2011/06/04 06:00
CRDT- 2011/02/03 06:00
PHST- 2011/02/03 06:00 [entrez]
PHST- 2011/02/03 06:00 [pubmed]
PHST- 2011/06/04 06:00 [medline]
AID - 18/1/6 [pii]
AID - 10.1177/0969733010388105 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Jan;18(1):6-8. doi: 10.1177/0969733010388105.


PMID- 21285191
OWN - NLM
STAT- MEDLINE
DCOM- 20110603
LR  - 20110202
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 18
IP  - 1
DP  - 2011 Jan
TI  - The ethics of impact factors.
PG  - 3-5
LID - 10.1177/0969733010388353 [doi]
FAU - Gallagher, Ann
AU  - Gallagher A
LA  - eng
PT  - Editorial
PT  - Introductory Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - *Ethics, Nursing
MH  - Humans
MH  - *Journal Impact Factor
MH  - *Journalism, Medical
MH  - *Nurse's Role
MH  - Nurse-Patient Relations/*ethics
EDAT- 2011/02/03 06:00
MHDA- 2011/06/04 06:00
CRDT- 2011/02/03 06:00
PHST- 2011/02/03 06:00 [entrez]
PHST- 2011/02/03 06:00 [pubmed]
PHST- 2011/06/04 06:00 [medline]
AID - 18/1/3 [pii]
AID - 10.1177/0969733010388353 [doi]
PST - ppublish
SO  - Nurs Ethics. 2011 Jan;18(1):3-5. doi: 10.1177/0969733010388353.


PMID- 21285100
OWN - NLM
STAT- MEDLINE
DCOM- 20110524
LR  - 20170123
IS  - 1557-9700 (Electronic)
IS  - 1075-2730 (Linking)
VI  - 62
IP  - 2
DP  - 2011 Feb
TI  - Inpatient psychiatric care in the 21st century: the need for reform.
PG  - 206-9
LID - 10.1176/ps.62.2.pss6202_0206 [doi]
AB  - Driven by financial pressures, the sole focus of psychiatric inpatient treatment 
      has become safety and crisis stabilization. Data are lacking on outcomes of
      ultrashort-stay hospitalizations; however, such stays may diminish opportunities 
      for a sustained recovery. In the absence of an evidence base to guide clinicians 
      and policy makers, mental health professionals have an ethical obligation to
      promote what they consider to be best practice. This Open Forum focuses on the
      need to reconsider the current model of inpatient hospitalization in order to
      maximize positive outcomes and emphasize appropriate transition to the community 
      and less intensive levels of care. A model of care is presented based on rapid
      formulation of diagnosis, goals, and treatment modalities before treatment
      begins. Three phases are described--assessment, implementation, and
      resolution--with specific principles to guide length-of-stay decisions and
      requirements for staffing.
FAU - Glick, Ira D
AU  - Glick ID
AD  - Department of Psychiatry and Behavioral Sciences, Stanford University School of
      Medicine, Stanford, California, USA.
FAU - Sharfstein, Steven S
AU  - Sharfstein SS
FAU - Schwartz, Harold I
AU  - Schwartz HI
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Psychiatr Serv
JT  - Psychiatric services (Washington, D.C.)
JID - 9502838
SB  - IM
CIN - Psychiatr Serv. 2011 Feb;62(2):117. PMID: 21285085
CIN - Psychiatr Serv. 2011 Apr;62(4):434-5; author reply 435. PMID: 21459998
CIN - Psychiatr Serv. 2011 Apr;62(4):434; author reply 435. PMID: 21459999
CIN - Psychiatr Serv. 2011 May;62(5):563; author reply 563-4. PMID: 21532091
MH  - *Health Care Reform
MH  - Health Policy
MH  - *Hospitalization
MH  - Humans
MH  - Inpatients
MH  - Length of Stay
MH  - Mental Disorders/diagnosis/*therapy
MH  - Treatment Outcome
EDAT- 2011/02/03 06:00
MHDA- 2011/05/25 06:00
CRDT- 2011/02/03 06:00
PHST- 2011/02/03 06:00 [entrez]
PHST- 2011/02/03 06:00 [pubmed]
PHST- 2011/05/25 06:00 [medline]
AID - 62/2/206 [pii]
AID - 10.1176/ps.62.2.pss6202_0206 [doi]
PST - ppublish
SO  - Psychiatr Serv. 2011 Feb;62(2):206-9. doi: 10.1176/ps.62.2.pss6202_0206.


PMID- 21285056
OWN - NLM
STAT- MEDLINE
DCOM- 20110317
LR  - 20170517
IS  - 1931-3543 (Electronic)
IS  - 0012-3692 (Linking)
VI  - 139
IP  - 2
DP  - 2011 Feb
TI  - Shaping patients' decisions.
PG  - 424-429
LID - S0012-3692(11)60084-6 [pii]
LID - 10.1378/chest.10-0605 [doi]
AB  - Many physicians struggle to strike an acceptable balance between respecting
      patient autonomy and guiding patients' decisions toward what is in their best
      interests based on their expressed values and long-term goals. Over the past 40
      years, the ethical principle of respect for autonomy has gained primacy in
      Western medicine, but judgments about the appropriate dose of influence on
      patient decisions have been clouded by misconceptions about patient autonomy. In 
      this article, we consider three such misconceptions with the goal of helping
      physicians to optimally promote their patients' interests.
FAU - Swindell, J S
AU  - Swindell JS
AD  - Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston,
      TX. Electronic address: jsswinde@bcm.edu.
FAU - McGuire, Amy L
AU  - McGuire AL
AD  - Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston,
      TX.
FAU - Halpern, Scott D
AU  - Halpern SD
AD  - Division of Pulmonary and Critical Care Medicine, Center for Bioethics, Leonard
      Davis Institute of Health Economics, and Center for Clinical Epidemiology and
      Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Chest
JT  - Chest
JID - 0231335
SB  - IM
CIN - Chest. 2011 Feb;139(2):243-4. PMID: 21285052
MH  - Decision Making/*ethics
MH  - Humans
MH  - *Patient Participation
MH  - *Personal Autonomy
MH  - Physician-Patient Relations/*ethics
EDAT- 2011/02/03 06:00
MHDA- 2011/03/18 06:00
CRDT- 2011/02/03 06:00
PHST- 2011/02/03 06:00 [entrez]
PHST- 2011/02/03 06:00 [pubmed]
PHST- 2011/03/18 06:00 [medline]
AID - S0012-3692(11)60084-6 [pii]
AID - 10.1378/chest.10-0605 [doi]
PST - ppublish
SO  - Chest. 2011 Feb;139(2):424-429. doi: 10.1378/chest.10-0605.


PMID- 21284625
OWN - NLM
STAT- MEDLINE
DCOM- 20110418
LR  - 20110202
IS  - 1095-8649 (Electronic)
IS  - 0022-1112 (Linking)
VI  - 78
IP  - 2
DP  - 2011 Feb
TI  - Ethical justification for the use and treatment of fishes in research: an update.
PG  - 393-4
LID - 10.1111/j.1095-8649.2010.02900.x [doi]
FAU - Metcalfe, J D
AU  - Metcalfe JD
FAU - Craig, J F
AU  - Craig JF
LA  - eng
PT  - Editorial
PL  - England
TA  - J Fish Biol
JT  - Journal of fish biology
JID - 0214055
SB  - IM
MH  - Animal Experimentation/*ethics
MH  - Animal Welfare
MH  - Animals
MH  - *Fishes
EDAT- 2011/02/03 06:00
MHDA- 2011/04/19 06:00
CRDT- 2011/02/03 06:00
PHST- 2011/02/03 06:00 [entrez]
PHST- 2011/02/03 06:00 [pubmed]
PHST- 2011/04/19 06:00 [medline]
AID - 10.1111/j.1095-8649.2010.02900.x [doi]
PST - ppublish
SO  - J Fish Biol. 2011 Feb;78(2):393-4. doi: 10.1111/j.1095-8649.2010.02900.x.


PMID- 21284454
OWN - NLM
STAT- MEDLINE
DCOM- 20110408
LR  - 20181201
IS  - 1092-0684 (Electronic)
IS  - 1092-0684 (Linking)
VI  - 30
IP  - 2
DP  - 2011 Feb
TI  - Egas Moniz (1874-1955) and the "invention" of modern psychosurgery: a historical 
      and ethical reanalysis under special consideration of Portuguese original
      sources.
PG  - E8
LID - 10.3171/2010.10.FOCUS10214 [doi]
AB  - The Portuguese neurologist Egas Moniz (1874-1955) is often regarded as the
      founder of psychosurgery. He performed the first prefrontal leukotomy in
      1935-about 75 years ago-with the help of neurosurgeon Almeida Lima (1903-1985)
      [corrected]. In contrast to the psychosurgical interventions performed by the
      Swiss psychiatrist Gottlieb Burckhardt (1836-1907), Moniz's interventions on the 
      white brain substance caught great attention worldwide. As a matter of fact, it
      was this repercussion that led to the award of the Nobel Prize for Medicine in
      1949, an award that is still highly controversial today. The goal of the present 
      article is to reconstruct the historical background of the first leukotomies, the
      tangible expert debate since 1935 on the indication and legitimacy of these
      interventions, and their contemporary and recent (ethical) evaluation. Special
      focus will be set on the original Portuguese literature, which has been given too
      little attention thus far in the English-language literature.
FAU - Gross, Dominik
AU  - Gross D
AD  - Institute for History, Theory and Ethics of Medicine, RWTH Aachen University,
      Aachen, Germany. dgross@ukaachen.de
FAU - Schafer, Gereon
AU  - Schafer G
LA  - eng
PT  - Biography
PT  - Historical Article
PT  - Journal Article
PT  - Portrait
PL  - United States
TA  - Neurosurg Focus
JT  - Neurosurgical focus
JID - 100896471
SB  - IM
EIN - Neurosurg Focus. 2011 Apr;30(4).doi: 10.3171/2011.3.FOCUS10214a
MH  - Aged
MH  - Ethics, Medical/*history
MH  - History, 19th Century
MH  - History, 20th Century
MH  - Humans
MH  - Male
MH  - Nobel Prize
MH  - Portugal
MH  - Psychosurgery/*ethics/*history
PS  - Moniz E
FPS - Moniz, Egas
EDAT- 2011/02/03 06:00
MHDA- 2011/04/09 06:00
CRDT- 2011/02/03 06:00
PHST- 2011/02/03 06:00 [entrez]
PHST- 2011/02/03 06:00 [pubmed]
PHST- 2011/04/09 06:00 [medline]
AID - 10.3171/2010.10.FOCUS10214 [doi]
PST - ppublish
SO  - Neurosurg Focus. 2011 Feb;30(2):E8. doi: 10.3171/2010.10.FOCUS10214.


PMID- 21283153
OWN - NLM
STAT- MEDLINE
DCOM- 20110323
LR  - 20161013
IS  - 1715-3360 (Electronic)
IS  - 0008-4182 (Linking)
VI  - 46
IP  - 1
DP  - 2011 Feb
TI  - Fee splitting in ophthalmology.
PG  - 21-7
LID - 10.3129/i10-097 [doi]
AB  - Fee splitting and co-management are common practices in ophthalmology. These
      arrangements may conflict with the ethical principles governing the
      doctor-patient relationship, may constitute professional misconduct, and at
      times, may be illegal. Implications and perceptions of these practices may vary
      between different cultures. Full disclosure to the patient may minimize the
      adverse effects of conflicts of interest that arise from these practices, and may
      thereby allow these practices to be deemed acceptable by some cultural morays,
      professional guidelines, or by law. Disclosure does not necessarily relieve the
      physician from a potential ethical compromise. This review examines the practice 
      of fee splitting in ophthalmology, its legal implications, the policies or
      guidelines governing such arrangements, and the possible ethical ramifications. A
      comparative view between 3 countries, Canada, the United States, and Oman, was
      conducted; illustrating that even in disparate cultures, there may be some
      universality to the application of ethical principles.
FAU - Levin, Alex V
AU  - Levin AV
AD  - Pediatric Ophthalmology and Ocular Genetics, Wills Eye Institute, Philadelphia,
      PA, USA. alevin@willseye.org
FAU - Ganesh, Anuradha
AU  - Ganesh A
FAU - Al-Busaidi, Ahmed
AU  - Al-Busaidi A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Can J Ophthalmol
JT  - Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
JID - 0045312
SB  - IM
CIN - Can J Ophthalmol. 2011 Feb;46(1):13-4. PMID: 21283150
MH  - Canada
MH  - Conflict of Interest/*economics
MH  - *Ethics, Professional
MH  - *Fees, Medical
MH  - Humans
MH  - Oman
MH  - Ophthalmology/*economics
MH  - Patient-Centered Care
MH  - Practice Patterns, Physicians'
MH  - Referral and Consultation/*economics
MH  - United States
EDAT- 2011/02/02 06:00
MHDA- 2011/03/24 06:00
CRDT- 2011/02/02 06:00
PHST- 2011/02/02 06:00 [entrez]
PHST- 2011/02/02 06:00 [pubmed]
PHST- 2011/03/24 06:00 [medline]
AID - S0008-4182(11)80005-0 [pii]
AID - 10.3129/i10-097 [doi]
PST - ppublish
SO  - Can J Ophthalmol. 2011 Feb;46(1):21-7. doi: 10.3129/i10-097.


PMID- 21283074
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20110303
IS  - 1827-1596 (Electronic)
IS  - 0375-9393 (Linking)
VI  - 77
IP  - 2
DP  - 2011 Feb
TI  - Law and medical ethics: in defense of reality.
PG  - 242
FAU - Sartea, C
AU  - Sartea C
FAU - Zanzonico, R
AU  - Zanzonico R
FAU - Carassiti, M
AU  - Carassiti M
LA  - eng
PT  - Comment
PT  - Letter
DEP - 20110201
PL  - Italy
TA  - Minerva Anestesiol
JT  - Minerva anestesiologica
JID - 0375272
SB  - IM
CON - Minerva Anestesiol. 2010 Jul;76(7):548-9. PMID: 20613696
MH  - Death
MH  - *Ethics, Medical
MH  - Humans
MH  - Italy
MH  - *Legislation, Medical
MH  - Personal Autonomy
EDAT- 2011/02/02 06:00
MHDA- 2011/06/29 06:00
CRDT- 2011/02/02 06:00
PHST- 2011/02/02 06:00 [entrez]
PHST- 2011/02/02 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
AID - R02116653 [pii]
PST - ppublish
SO  - Minerva Anestesiol. 2011 Feb;77(2):242. Epub 2011 Feb 1.


PMID- 21282689
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20191210
IS  - 1943-4723 (Electronic)
IS  - 0002-8177 (Linking)
VI  - 142
IP  - 2
DP  - 2011 Feb
TI  - What are the ethical issues regarding the use of honorary degrees and other
      nonacademic designations?
PG  - 205-7
CN  - American Dental Association Council on Ethics, Bylaws and Judicial Affairs
AD  - American Dental Association Council on Ethics, Bylaws and Judicial Affairs, 211
      E. Chicago Ave., Chicago, Ill. 60611, USA. ethics@ada.org
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Am Dent Assoc
JT  - Journal of the American Dental Association (1939)
JID - 7503060
SB  - IM
MH  - Advertising/*ethics/legislation & jurisprudence
MH  - Awards and Prizes
MH  - Dentists/*ethics
MH  - *Ethics, Dental
MH  - Humans
MH  - Specialty Boards/legislation & jurisprudence
MH  - Terminology as Topic
MH  - United States
EDAT- 2011/02/02 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/02/02 06:00
PHST- 2011/02/02 06:00 [entrez]
PHST- 2011/02/02 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0002-8177(14)61503-8 [pii]
AID - 10.14219/jada.archive.2011.0066 [doi]
PST - ppublish
SO  - J Am Dent Assoc. 2011 Feb;142(2):205-7. doi: 10.14219/jada.archive.2011.0066.


PMID- 21282132
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20220408
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 6
DP  - 2011 Jun
TI  - Attitudes to perinatal postmortem: parental views about research participation.
PG  - 364-7
LID - 10.1136/jme.2010.038505 [doi]
AB  - OBJECTIVE: To study parental attitudes to participating in questionnaire research
      about perinatal postmortem immediately after late miscarriage, stillbirth and
      termination for fetal abnormality. DESIGN: Prospective self-completion
      questionnaire. SETTING: UK fetal medicine and delivery unit. PATIENTS: 35 women
      and their partners after second or third trimester pregnancy loss, making
      decisions about having a postmortem. METHODS: Participants were asked to complete
      a questionnaire about postmortem decision-making which included questions about
      their attitudes to taking part in research. Prior to giving full approval for the
      study, the Research Ethics Committee (REC) requested feedback after 10
      questionnaires had been returned. RESULTS: Responses from the first 10
      participants were positive about the research and the REC allowed the study to
      continue. 31 questionnaires were received from parents of 17 babies (49% of those
      asked; 16 from mothers, 15 from fathers). Of the 22 participants who answered a
      question about the impact of participating in this research, 73% stated that
      completing the questionnaire had helped them feel better about the decision
      whether or not to consent to postmortem and none reported any adverse effect of
      completing the questionnaire. Additional comments made by 19 participants
      supported this finding. CONCLUSION: Research into this sensitive area of
      perinatal medicine where there is a poor outcome is possible and is indeed well
      received by many parents. RECs should not automatically take a negative stance
      towards studies of this type.
FAU - Breeze, Andrew C G
AU  - Breeze AC
AD  - Centre for Family Research, University of Cambridge, Free School Lane, Cambridge,
      UK.
FAU - Statham, Helen
AU  - Statham H
FAU - Hackett, Gerald A
AU  - Hackett GA
FAU - Jessop, Flora A
AU  - Jessop FA
FAU - Lees, Christoph C
AU  - Lees CC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110130
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Abortion, Spontaneous/*psychology
MH  - Adolescent
MH  - Adult
MH  - *Attitude to Death
MH  - Female
MH  - *Fetal Death
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Parents/*psychology
MH  - Pregnancy
MH  - Research Subjects/psychology
MH  - Stillbirth/*psychology
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2011/02/02 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/02/02 06:00
PHST- 2011/02/02 06:00 [entrez]
PHST- 2011/02/02 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - jme.2010.038505 [pii]
AID - 10.1136/jme.2010.038505 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Jun;37(6):364-7. doi: 10.1136/jme.2010.038505. Epub 2011 Jan
      30.


PMID- 21282078
OWN - NLM
STAT- MEDLINE
DCOM- 20120319
LR  - 20181201
IS  - 1878-0326 (Electronic)
IS  - 1872-4973 (Linking)
VI  - 6
IP  - 1
DP  - 2012 Jan
TI  - Bracketing off population does not advance ethical reflection on EVCs: a reply to
      Kayser and Schneider.
PG  - e16-7; author reply e18-9
LID - 10.1016/j.fsigen.2010.12.012 [doi]
FAU - M'charek, Amade
AU  - M'charek A
FAU - Toom, Victor
AU  - Toom V
FAU - Prainsack, Barbara
AU  - Prainsack B
LA  - eng
PT  - Letter
PT  - Comment
DEP - 20110201
PL  - Netherlands
TA  - Forensic Sci Int Genet
JT  - Forensic science international. Genetics
JID - 101317016
RN  - 9007-49-2 (DNA)
SB  - IM
CON - Forensic Sci Int Genet. 2009 Jun;3(3):154-61. PMID: 19414162
MH  - DNA/*genetics
MH  - DNA Fingerprinting/*ethics
MH  - Forensic Genetics/*ethics
MH  - Humans
MH  - *Motivation
MH  - *Phenotype
EDAT- 2011/02/02 06:00
MHDA- 2012/03/20 06:00
CRDT- 2011/02/02 06:00
PHST- 2010/09/10 00:00 [received]
PHST- 2010/12/26 00:00 [accepted]
PHST- 2011/02/02 06:00 [entrez]
PHST- 2011/02/02 06:00 [pubmed]
PHST- 2012/03/20 06:00 [medline]
AID - S1872-4973(11)00010-X [pii]
AID - 10.1016/j.fsigen.2010.12.012 [doi]
PST - ppublish
SO  - Forensic Sci Int Genet. 2012 Jan;6(1):e16-7; author reply e18-9. doi:
      10.1016/j.fsigen.2010.12.012. Epub 2011 Feb 1.


PMID- 21281768
OWN - NLM
STAT- MEDLINE
DCOM- 20110525
LR  - 20110201
IS  - 1878-0369 (Electronic)
IS  - 0001-2092 (Linking)
VI  - 93
IP  - 2
DP  - 2011 Feb
TI  - Engaging undergraduate nursing students in perioperative research.
PG  - 249-58
LID - 10.1016/j.aorn.2010.05.029 [doi]
AB  - Actively engaging in perioperative research lays a framework for stimulating
      interest in future research possibilities and provides students and graduate
      nurses with challenges to keep them interested as their careers progress. In this
      article, former honors students and a faculty researcher share their perceptions 
      of participating in perioperative research. The primary investigator must
      emphasize learning throughout the process, be available to the students, provide 
      structured guidance, and clarify the goals and expectations of the research
      experience. The students gain a greater understanding of the research process,
      discover the dedication and ethical values that are required of the researcher,
      learn how theory becomes the underlying framework for the research, and discover 
      how descriptive statistics can be used to help explain the study results.
      Involvement in applied research may encourage these students to continue to
      contribute to evidence-based practice when they are employed as nurses and thus
      improve patient care.
CI  - Copyright (c) 2011 AORN, Inc. Published by Elsevier Inc. All rights reserved.
FAU - Taber, Kimberly
AU  - Taber K
AD  - Orlando Regional Medical Center, FL, USA.
FAU - Taber, Renee
AU  - Taber R
FAU - Galante, Larissa
AU  - Galante L
FAU - Sigsby, Linda M
AU  - Sigsby LM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - AORN J
JT  - AORN journal
JID - 0372403
SB  - IM
MH  - Evidence-Based Nursing
MH  - Humans
MH  - Learning
MH  - *Nursing Research
MH  - *Perioperative Nursing
MH  - *Students, Nursing
EDAT- 2011/02/02 06:00
MHDA- 2011/05/26 06:00
CRDT- 2011/02/02 06:00
PHST- 2010/03/06 00:00 [received]
PHST- 2010/05/02 00:00 [accepted]
PHST- 2011/02/02 06:00 [entrez]
PHST- 2011/02/02 06:00 [pubmed]
PHST- 2011/05/26 06:00 [medline]
AID - S0001-2092(10)00998-1 [pii]
AID - 10.1016/j.aorn.2010.05.029 [doi]
PST - ppublish
SO  - AORN J. 2011 Feb;93(2):249-58. doi: 10.1016/j.aorn.2010.05.029.


PMID- 21281392
OWN - NLM
STAT- MEDLINE
DCOM- 20110525
LR  - 20110201
IS  - 1440-1800 (Electronic)
IS  - 1320-7881 (Linking)
VI  - 18
IP  - 1
DP  - 2011 Mar
TI  - The good, the bad and the 'not so bad': reflecting on moral appraisal in
      practice.
PG  - 21-8
LID - 10.1111/j.1440-1800.2011.00531.x [doi]
AB  - The aim of this study is to facilitate reflection on the moral merit of
      practitioners in various contexts. Insight is gained from Aristotelian and
      Kantian accounts of moral character and an original framework for reflection is
      presented as an adjunct to ethical theory and principles considered when
      appraising others. In relation to states of character, there is an irreconcilable
      difference between Kantian (deontic) and Aristotelian (aretaic) conceptions of
      the nature of full virtue (excellence of character), but at the same time it can 
      be argued that in relation to practice their approaches complement each other. It
      is also argued that in relation to caring for the vulnerable, Aristotle's
      conception of full virtue is more compelling than Kant's. On the other hand,
      Kant's notion of self-serving action is important in nursing and it therefore
      needs to be considered when reflecting on professional conduct. The conclusion
      reached is that Aristotelian and Kantian accounts of character appraisal should
      be used in a combined approach to moral appraisal. This approach draws on the
      accounts of both philosophers and offers valuable insight into moral character,
      professional conduct and, in a more formal setting, fitness to practise.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Begley, Ann Marie
AU  - Begley AM
AD  - School of Nursing and Midwifery, The Queen's University of Belfast, Belfast, UK. 
      a.begley@qub.ac.uk
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Nurs Inq
JT  - Nursing inquiry
JID - 9505881
MH  - *Ethics, Nursing
MH  - Humans
MH  - Morals
MH  - Nurse's Role/*psychology
MH  - *Nursing
MH  - *Virtues
EDAT- 2011/02/02 06:00
MHDA- 2011/05/26 06:00
CRDT- 2011/02/02 06:00
PHST- 2011/02/02 06:00 [entrez]
PHST- 2011/02/02 06:00 [pubmed]
PHST- 2011/05/26 06:00 [medline]
AID - 10.1111/j.1440-1800.2011.00531.x [doi]
PST - ppublish
SO  - Nurs Inq. 2011 Mar;18(1):21-8. doi: 10.1111/j.1440-1800.2011.00531.x.


PMID- 21281302
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20151119
IS  - 1466-7657 (Electronic)
IS  - 0020-8132 (Linking)
VI  - 58
IP  - 1
DP  - 2011 Mar
TI  - Ethics, culture and nursing practice in Ghana.
PG  - 109-14
LID - 10.1111/j.1466-7657.2010.00852.x [doi]
AB  - OBJECTIVE: This paper describes how nurses in Ghana approach ethical problems.
      BACKGROUND: The International Council of Nurses' (ICN) Code for Nurses (2006)
      that serves as the model for professional code of ethics worldwide also
      acknowledges respect for healthy cultural values. Using the ICN's Code and
      universal ethical principles as a benchmark, a survey was conducted in 2009 to
      ascertain how nurses in Ghana respond to ethical and cultural issues in their
      practice. METHODS: The study was qualitative with 200 participant nurses. Data
      were obtained through anonymous self-administered questionnaires. Descriptive
      statistics were used to analyze the data. FINDINGS: Nurses' approaches to ethical
      problems in Ghana do not always meet expectations of the ICN Code for Nurses.
      They are also informed by local ethical practices related to the institutional
      setting and cultural environment in the country. While some cultural values
      complemented the ICN's Code and universal ethical principles, others conflicted
      with them. NURSING IMPLICATIONS: These data can assist nurses to provide
      culturally competent solutions to ethical dilemmas in their practice. Dynamic
      communication between nurses and patients/clients, intentional study of local
      cultural beliefs, and the development of ethics education will improve the
      conformity between universal ethical standards and local cultural values.
CI  - (c) 2011 The Authors. International Nursing Review (c) 2011 International Council
      of Nurses.
FAU - Donkor, N T
AU  - Donkor NT
AD  - Canadian University College, Lacombe, Alberta, Canada. ndonkor@cauc.ca
FAU - Andrews, L D
AU  - Andrews LD
LA  - eng
PT  - Journal Article
DEP - 20110109
PL  - England
TA  - Int Nurs Rev
JT  - International nursing review
JID - 7808754
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Cultural Characteristics
MH  - Developing Countries
MH  - *Ethics, Nursing
MH  - Female
MH  - Ghana
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Middle Aged
MH  - Professional Autonomy
MH  - Professional Competence
MH  - Surveys and Questionnaires
EDAT- 2011/02/02 06:00
MHDA- 2011/06/29 06:00
CRDT- 2011/02/02 06:00
PHST- 2011/02/02 06:00 [entrez]
PHST- 2011/02/02 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
AID - 10.1111/j.1466-7657.2010.00852.x [doi]
PST - ppublish
SO  - Int Nurs Rev. 2011 Mar;58(1):109-14. doi: 10.1111/j.1466-7657.2010.00852.x. Epub 
      2011 Jan 9.


PMID- 21280152
OWN - NLM
STAT- MEDLINE
DCOM- 20110502
LR  - 20110131
IS  - 1549-4918 (Electronic)
IS  - 1066-5099 (Linking)
VI  - 29
IP  - 1
DP  - 2011 Jan
TI  - Law, ethics, religion, and clinical translation in the 21st century--a
      conversation with Cinzia Rota. Interview by Majlinda Lako, Alan O. Trounson, and 
      Susan Daher.
PG  - 1-2
LID - 10.1002/stem.565 [doi]
FAU - Rota, Cinzia
AU  - Rota C
LA  - eng
PT  - Interview
PL  - England
TA  - Stem Cells
JT  - Stem cells (Dayton, Ohio)
JID - 9304532
SB  - IM
MH  - Animals
MH  - Humans
MH  - Italy
MH  - Jurisprudence
MH  - Legislation as Topic/*ethics
MH  - Mice
MH  - Religion
MH  - Stem Cell Research/*ethics/*legislation & jurisprudence
MH  - *Stem Cells
EDAT- 2011/02/01 06:00
MHDA- 2011/05/03 06:00
CRDT- 2011/02/01 06:00
PHST- 2011/02/01 06:00 [entrez]
PHST- 2011/02/01 06:00 [pubmed]
PHST- 2011/05/03 06:00 [medline]
AID - 10.1002/stem.565 [doi]
PST - ppublish
SO  - Stem Cells. 2011 Jan;29(1):1-2. doi: 10.1002/stem.565.


PMID- 21279663
OWN - NLM
STAT- MEDLINE
DCOM- 20120105
LR  - 20220317
IS  - 1248-9204 (Electronic)
IS  - 1248-9204 (Linking)
VI  - 15
IP  - 4
DP  - 2011 Aug
TI  - Histologic and biomechanical evaluation of a novel macroporous
      polytetrafluoroethylene knit mesh compared to lightweight and heavyweight
      polypropylene mesh in a porcine model of ventral incisional hernia repair.
PG  - 423-31
LID - 10.1007/s10029-011-0787-z [doi]
AB  - PURPOSE: To evaluate the biocompatibility of heavyweight polypropylene (HWPP),
      lightweight polypropylene (LWPP), and monofilament knit polytetrafluoroethylene
      (mkPTFE) mesh by comparing biomechanics and histologic response at 1, 3, and 5
      months in a porcine model of incisional hernia repair. METHODS: Bilateral
      full-thickness abdominal wall defects measuring 4 cm in length were created in 27
      Yucatan minipigs. Twenty-one days after hernia creation, animals underwent
      bilateral preperitoneal ventral hernia repair with 8 x 10 cm pieces of mesh.
      Repairs were randomized to Bard((R))Mesh (HWPP, Bard/Davol,
      http://www.davol.com), ULTRAPRO((R)) (LWPP, Ethicon, http://www.ethicon.com), and
      GORE((R))INFINIT Mesh (mkPTFE, Gore & Associates, http://www.gore.com). Nine
      animals were sacrificed at each timepoint (1, 3, and 5 months). At harvest, a 3 x
      4 cm sample of mesh and incorporated tissue was taken from the center of the
      implant site and subjected to uniaxial tensile testing at a rate of 0.42 mm/s.
      The maximum force (N) and tensile strength (N/cm) were measured with a
      tensiometer, and stiffness (N/mm) was calculated from the slope of the
      force-versus-displacement curve. Adjacent sections of tissue were stained with
      hematoxylin and eosin (H&E) and analyzed for inflammation, fibrosis, and tissue
      ingrowth. Data are reported as mean +/- SEM. Statistical significance (P < 0.05) 
      was determined using a two-way ANOVA and Bonferroni post-test. RESULTS: No
      significant difference in maximum force was detected between meshes at any of the
      time points (P > 0.05 for all comparisons). However, for each mesh type, the
      maximum strength at 5 months was significantly lower than that at 1 month (P <
      0.05). No significant difference in stiffness was detected between the mesh types
      or between timepoints (P > 0.05 for all comparisons). No significant differences 
      with regard to inflammation, fibrosis, or tissue ingrowth were detected between
      mesh types at any time point (P > 0.09 for all comparisons). However, over time, 
      inflammation decreased significantly for all mesh types (P < 0.001) and tissue
      ingrowth reached a slight peak between 1 and 3 months (P = 0.001) but did not
      significantly change thereafter (P > 0.09). CONCLUSIONS: The maximum tensile
      strength of mesh in the abdominal wall decreased over time for HWPP, LWPP, and
      mkPTFE mesh materials alike. This trend may actually reflect inability to
      adequately grip specimens at later time points rather than any mesh-specific
      trend. Histologically, inflammation decreased with time (P = 0.000), and tissue
      ingrowth increased (P = 0.019) for all meshes. No specific trends were observed
      between the polypropylene meshes and the monofilament knit PTFE, suggesting that 
      this novel construction may be a suitable alternative to existing polypropylene
      meshes.
FAU - Melman, L
AU  - Melman L
AD  - Section of Minimally Invasive Surgery, Department of Surgery, Washington
      University School of Medicine, 660 South Euclid Avenue, Campus Box #8109, St.
      Louis, MO, USA.
FAU - Jenkins, E D
AU  - Jenkins ED
FAU - Hamilton, N A
AU  - Hamilton NA
FAU - Bender, L C
AU  - Bender LC
FAU - Brodt, M D
AU  - Brodt MD
FAU - Deeken, C R
AU  - Deeken CR
FAU - Greco, S C
AU  - Greco SC
FAU - Frisella, M M
AU  - Frisella MM
FAU - Matthews, B D
AU  - Matthews BD
LA  - eng
GR  - P30 DK052574/DK/NIDDK NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110130
PL  - France
TA  - Hernia
JT  - Hernia : the journal of hernias and abdominal wall surgery
JID - 9715168
RN  - 0 (Polypropylenes)
RN  - 9002-84-0 (Polytetrafluoroethylene)
SB  - IM
MH  - Abdominal Wall/*pathology
MH  - Analysis of Variance
MH  - Animals
MH  - Biomechanical Phenomena
MH  - Disease Models, Animal
MH  - Elasticity
MH  - Hernia, Ventral/*surgery
MH  - Inflammation/pathology
MH  - Materials Testing
MH  - *Polypropylenes/adverse effects
MH  - *Polytetrafluoroethylene/adverse effects
MH  - *Surgical Mesh/adverse effects
MH  - Swine
MH  - Tensile Strength
MH  - Time Factors
PMC - PMC3826829
MID - NIHMS513407
EDAT- 2011/02/01 06:00
MHDA- 2012/01/06 06:00
CRDT- 2011/02/01 06:00
PHST- 2010/08/16 00:00 [received]
PHST- 2011/01/09 00:00 [accepted]
PHST- 2011/02/01 06:00 [entrez]
PHST- 2011/02/01 06:00 [pubmed]
PHST- 2012/01/06 06:00 [medline]
AID - 10.1007/s10029-011-0787-z [doi]
PST - ppublish
SO  - Hernia. 2011 Aug;15(4):423-31. doi: 10.1007/s10029-011-0787-z. Epub 2011 Jan 30.


PMID- 21279481
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20211020
IS  - 2629-3277 (Electronic)
IS  - 2629-3277 (Linking)
VI  - 7
IP  - 3
DP  - 2011 Sep
TI  - Publishing SNP genotypes of human embryonic stem cell lines: policy statement of 
      the International Stem Cell Forum Ethics Working Party.
PG  - 482-4
LID - 10.1007/s12015-010-9226-2 [doi]
AB  - Novel methods and associated tools permitting individual identification in
      publicly accessible SNP databases have become a debatable issue. There is growing
      concern that current technical and ethical safeguards to protect the identities
      of donors could be insufficient. In the context of human embryonic stem cell
      research, there are no studies focusing on the probability that an hESC line
      donor could be identified by analyzing published SNP profiles and associated
      genotypic and phenotypic information. We present the International Stem Cell
      Forum (ISCF) Ethics Working Party's Policy Statement on "Publishing SNP Genotypes
      of Human Embryonic Stem Cell Lines (hESC)". The Statement prospectively addresses
      issues surrounding the publication of genotypic data and associated annotations
      of hESC lines in open access databases. It proposes a balanced approach between
      the goals of open science and data sharing with the respect for fundamental
      bioethical principles (autonomy, privacy, beneficence, justice and research merit
      and integrity).
FAU - Knoppers, Bartha M
AU  - Knoppers BM
AD  - International Stem Cell Forum Ethics Working Party. Centre of Genomics and
      Policy, Faculty of Medicine, Department of Human Genetics McGill University, 740 
      Dr. Penfield Avenue, Rm 5214, Montreal, QC, H3A 1A4, Canada.
FAU - Isasi, Rosario
AU  - Isasi R
FAU - Benvenisty, Nissim
AU  - Benvenisty N
FAU - Kim, Ock-Joo
AU  - Kim OJ
FAU - Lomax, Geoffrey
AU  - Lomax G
FAU - Morris, Clive
AU  - Morris C
FAU - Murray, Thomas H
AU  - Murray TH
FAU - Lee, Eng Hin
AU  - Lee EH
FAU - Perry, Margery
AU  - Perry M
FAU - Richardson, Genevra
AU  - Richardson G
FAU - Sipp, Douglas
AU  - Sipp D
FAU - Tanner, Klaus
AU  - Tanner K
FAU - Wahlstrom, Jan
AU  - Wahlstrom J
FAU - de Wert, Guido
AU  - de Wert G
FAU - Zeng, Fanyi
AU  - Zeng F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Stem Cell Rev Rep
JT  - Stem cell reviews and reports
JID - 101752767
SB  - IM
MH  - *Cell Line
MH  - Embryonic Stem Cells/*physiology
MH  - *Genotype
MH  - Humans
MH  - International Cooperation
MH  - *Policy
MH  - *Polymorphism, Single Nucleotide
MH  - *Stem Cell Research/ethics/legislation & jurisprudence
PMC - PMC3137773
EDAT- 2011/02/01 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/02/01 06:00
PHST- 2011/02/01 06:00 [entrez]
PHST- 2011/02/01 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - 10.1007/s12015-010-9226-2 [doi]
PST - ppublish
SO  - Stem Cell Rev Rep. 2011 Sep;7(3):482-4. doi: 10.1007/s12015-010-9226-2.


PMID- 21278669
OWN - NLM
STAT- MEDLINE
DCOM- 20110301
LR  - 20110131
IS  - 1357-6321 (Print)
IS  - 1357-6321 (Linking)
VI  - 17
IP  - 1
DP  - 2011 Jan
TI  - Accessing vulnerable research populations: an experience with gatekeepers of
      ethical approval.
PG  - 14-8
AB  - Accessing vulnerable populations for research purposes can be difficult, as
      participants must be sheltered from research that might be insensitive,
      intrusive, and potentially distressing. People diagnosed with a life-limiting
      condition may be vulnerable, and involving such people in research samples may be
      fraught with difficulties. Nevertheless, it is important that these vulnerable
      populations participate in health and social-care research so that their
      requirements and opinions can be learnt. This paper describes an experience of
      proceeding through an ethical approval process for a proposed qualitative
      research study into the preferred place of death of a group of potentially
      vulnerable hospice patients. Research of this nature had never been undertaken at
      the hospice before, and the researchers expected to encounter a degree and
      variety of gatekeeping when seeking access to this sensitive population.
FAU - Walker, Susan
AU  - Walker S
AD  - Institute for Life Course Studies, Keele University, Staffordshire, UK.
FAU - Read, Sue
AU  - Read S
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Palliat Nurs
JT  - International journal of palliative nursing
JID - 9506762
MH  - *Ethics
MH  - *Nursing Research
MH  - *Vulnerable Populations
EDAT- 2011/02/01 06:00
MHDA- 2011/03/02 06:00
CRDT- 2011/02/01 06:00
PHST- 2011/02/01 06:00 [entrez]
PHST- 2011/02/01 06:00 [pubmed]
PHST- 2011/03/02 06:00 [medline]
AID - 10.12968/ijpn.2011.17.1.14 [doi]
PST - ppublish
SO  - Int J Palliat Nurs. 2011 Jan;17(1):14-8. doi: 10.12968/ijpn.2011.17.1.14.


PMID- 21278363
OWN - NLM
STAT- MEDLINE
DCOM- 20110908
LR  - 20151119
IS  - 1546-8364 (Electronic)
IS  - 1059-8405 (Linking)
VI  - 27
IP  - 3
DP  - 2011 Jun
TI  - Delegation of Glucagon(r) in the school setting: a comparison of state
      legislation.
PG  - 185-96
LID - 10.1177/1059840511398240 [doi]
AB  - Delegation of nursing procedures and medication in school is fraught with legal
      and ethical concerns for the school nurse. Because nurses may be responsible for 
      coordinating care for several school buildings, delegation of nursing care and
      medication administration has occurred out of necessity. Nurse Practice Acts in
      some states, but not all, allow for delegation of medication to unlicensed
      assistive personnel. This article explores Glucagon((R)) delegation laws in the
      United States and presents an argument against such delegation in states where
      Nurse Practice Acts do not allow for delegation of medication to unlicensed
      assistive personnel.
FAU - Wilt, Lori
AU  - Wilt L
AD  - Vernon Township School District, NJ, USA.
FAU - Foley, Marie
AU  - Foley M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110128
PL  - United States
TA  - J Sch Nurs
JT  - The Journal of school nursing : the official publication of the National
      Association of School Nurses
JID - 9206498
RN  - 9007-92-5 (Glucagon)
MH  - Delegation, Professional/*legislation & jurisprudence
MH  - Drug Administration Schedule
MH  - Glucagon/*administration & dosage/adverse effects
MH  - Humans
MH  - Medication Errors/prevention & control
MH  - Organizational Policy
MH  - Practice Patterns, Nurses'/*legislation & jurisprudence
MH  - Regional Medical Programs/legislation & jurisprudence
MH  - School Health Services/*legislation & jurisprudence
MH  - School Nursing/*legislation & jurisprudence
MH  - Schools/legislation & jurisprudence
MH  - United States
EDAT- 2011/02/01 06:00
MHDA- 2011/09/09 06:00
CRDT- 2011/02/01 06:00
PHST- 2011/02/01 06:00 [entrez]
PHST- 2011/02/01 06:00 [pubmed]
PHST- 2011/09/09 06:00 [medline]
AID - 1059840511398240 [pii]
AID - 10.1177/1059840511398240 [doi]
PST - ppublish
SO  - J Sch Nurs. 2011 Jun;27(3):185-96. doi: 10.1177/1059840511398240. Epub 2011 Jan
      28.


PMID- 21278322
OWN - NLM
STAT- MEDLINE
DCOM- 20110607
LR  - 20211020
IS  - 1940-5200 (Electronic)
IS  - 1078-3458 (Linking)
VI  - 17
IP  - 1
DP  - 2011 Jan
TI  - Implementing opt-out programs at Los Angeles county jail: a gateway to novel
      research and interventions.
PG  - 69-76
LID - 10.1177/1078345810385916 [doi]
AB  - Routine opt-out screening and vaccination programs are effective methods for
      improving public health in correctional populations. Jail-based rapid testing for
      HIV, hepatitis B and C, tuberculosis, syphilis, gonorrhea, and chlamydia can
      improve urban health by increasing diagnosis and linkage to care for infectious
      diseases. In addition, jail-based vaccination programs would significantly
      benefit community health and lower costs associated with tertiary level care. The
      paucity of ethical and rigorous scientific research among incarcerated
      populations excludes these marginalized members of society from potential
      advancements in correctional medicine and public health. Routine opt-out testing 
      programs would not only benefit the health of the correctional population but
      also serve as platforms for future research. Trials measuring the efficacy of new
      rapid tests, screening methods, novel vaccine delivery systems, or accelerated
      vaccine regimens would be greatly beneficial.
FAU - Malek, Mark
AU  - Malek M
AD  - Infection Control and Epidemiology Unit, Medical Services Bureau, Los Angeles
      County Sheriff's Department, Los Angeles, CA, USA. mamalek@lasd.org
FAU - Bazazi, Alexander R
AU  - Bazazi AR
FAU - Cox, Garrett
AU  - Cox G
FAU - Rival, Germaine
AU  - Rival G
FAU - Baillargeon, Jacques
AU  - Baillargeon J
FAU - Miranda, Armidia
AU  - Miranda A
FAU - Rich, Josiah D
AU  - Rich JD
LA  - eng
GR  - K24 DA022112/DA/NIDA NIH HHS/United States
GR  - K24 DA022112-01A2/DA/NIDA NIH HHS/United States
GR  - K24DA022112/DA/NIDA NIH HHS/United States
GR  - P30-AI-42853/AI/NIAID NIH HHS/United States
GR  - P30 AI042853/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Correct Health Care
JT  - Journal of correctional health care : the official journal of the National
      Commission on Correctional Health Care
JID - 9503759
SB  - IM
MH  - Adult
MH  - Choice Behavior
MH  - Female
MH  - Humans
MH  - Los Angeles
MH  - Male
MH  - Mass Screening
MH  - *Patient Acceptance of Health Care
MH  - *Prisons
MH  - Program Development
MH  - *Research
MH  - Sexually Transmitted Diseases/diagnosis
PMC - PMC3154702
MID - NIHMS314963
EDAT- 2011/02/01 06:00
MHDA- 2011/06/08 06:00
CRDT- 2011/02/01 06:00
PHST- 2011/02/01 06:00 [entrez]
PHST- 2011/02/01 06:00 [pubmed]
PHST- 2011/06/08 06:00 [medline]
AID - 17/1/69 [pii]
AID - 10.1177/1078345810385916 [doi]
PST - ppublish
SO  - J Correct Health Care. 2011 Jan;17(1):69-76. doi: 10.1177/1078345810385916.


PMID- 21278320
OWN - NLM
STAT- MEDLINE
DCOM- 20110607
LR  - 20220129
IS  - 1940-5200 (Electronic)
IS  - 1078-3458 (Linking)
VI  - 17
IP  - 1
DP  - 2011 Jan
TI  - Neuropsychological assessment in prisons: ethical and practical challenges.
PG  - 51-60
LID - 10.1177/1078345810385914 [doi]
AB  - Cognitive deficits, substance abuse, and mental illness are common among
      prisoners. Thus, for many prisoners, neuropsychological evaluations may be
      indicated to assess the degree of impairment and how these impairments may affect
      their behavior in the prison environment. However, many neuropsychological tests 
      were not designed for or normed on prisoners. This article highlights the unique 
      ethical and practical challenges to providing neuropsychological services to
      incarcerated individuals. Specifically, it discusses (a) limits to
      confidentiality, (b) issues related to informed consent, (c) how prison
      conditions may compromise the validity of testing, and (d) the impact of
      third-party observation of the evaluation. Recommendations and suggestions for
      resolving some of these difficulties are offered.
FAU - Vanderhoff, Holly
AU  - Vanderhoff H
AD  - Upstate Medical University, Syracuse, NY, USA.
FAU - Jeglic, Elizabeth L
AU  - Jeglic EL
FAU - Donovick, Peter J
AU  - Donovick PJ
LA  - eng
GR  - G1000758/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PL  - United States
TA  - J Correct Health Care
JT  - Journal of correctional health care : the official journal of the National
      Commission on Correctional Health Care
JID - 9503759
SB  - IM
MH  - Confidentiality
MH  - *Ethics
MH  - Humans
MH  - Informed Consent
MH  - Mental Disorders/diagnosis
MH  - *Neuropsychological Tests
MH  - Prisoners/*psychology
MH  - *Prisons
MH  - Reproducibility of Results
MH  - Restraint, Physical
EDAT- 2011/02/01 06:00
MHDA- 2011/06/08 06:00
CRDT- 2011/02/01 06:00
PHST- 2011/02/01 06:00 [entrez]
PHST- 2011/02/01 06:00 [pubmed]
PHST- 2011/06/08 06:00 [medline]
AID - 17/1/51 [pii]
AID - 10.1177/1078345810385914 [doi]
PST - ppublish
SO  - J Correct Health Care. 2011 Jan;17(1):51-60. doi: 10.1177/1078345810385914.


PMID- 21278132
OWN - NLM
STAT- MEDLINE
DCOM- 20110523
LR  - 20181201
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 4
DP  - 2011 Apr
TI  - Prevalence of depression in granted and refused requests for euthanasia and
      assisted suicide: a systematic review.
PG  - 205-11
LID - 10.1136/jme.2010.039057 [doi]
AB  - BACKGROUND: There is an established link between depression and interest in
      hastened death in patients who are seriously ill. Concern exists over the extent 
      of depression in patients who actively request euthanasia/physician-assisted
      suicide (PAS) and those who have their requests granted. OBJECTIVES: To estimate 
      the prevalence of depression in refused and granted requests for euthanasia/PAS
      and discuss these findings. Methods A systematic review was performed in MEDLINE 
      and PsycINFO in July 2010, identifying studies reporting rates of depression in
      requests for and cases of euthanasia/PAS. One author critically appraised the
      strength of the data using published criteria. RESULTS: 21 studies were included 
      covering four countries. There was considerable heterogeneity in methods of
      assessing depression and selecting patients. In the highest quality studies, in
      the Netherlands and Oregon, 8-47% of patients requesting euthanasia/PAS had
      depressive symptoms and 2-17% of completed euthanasia/PAS cases had depressive
      symptoms. In the Netherlands, depression was significantly higher in refused than
      granted requests, and there was no significant difference in the rate of
      depression between euthanasia cases and similar patients who had not made a
      request for euthanasia. CONCLUSION: It is unclear whether depression increases
      the probability of making a request for euthanasia/PAS, but in the Netherlands
      most requests in depressed patients are rejected, leaving a depression rate in
      cases that is similar to the surrounding population. Less evidence is available
      elsewhere, but some level of depression has been identified in patients
      undergoing euthanasia/PAS in all the countries studied. Whether the presence of
      depression is ever compatible with an ethical decision on euthanasia/PAS is
      discussed.
FAU - Levene, Ilana
AU  - Levene I
AD  - The Ethox Centre, University of Oxford, Badenoch Building, Old Road Campus,
      Oxford OX3 7LF, UK. ilana.levene@doctors.org.uk
FAU - Parker, Michael
AU  - Parker M
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20110127
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Algorithms
MH  - Decision Making
MH  - Depressive Disorder/*psychology
MH  - Euthanasia/legislation & jurisprudence/*psychology
MH  - Humans
MH  - Suicide, Assisted/legislation & jurisprudence/*psychology
MH  - Terminally Ill/*psychology
EDAT- 2011/02/01 06:00
MHDA- 2011/05/24 06:00
CRDT- 2011/02/01 06:00
PHST- 2011/02/01 06:00 [entrez]
PHST- 2011/02/01 06:00 [pubmed]
PHST- 2011/05/24 06:00 [medline]
AID - jme.2010.039057 [pii]
AID - 10.1136/jme.2010.039057 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Apr;37(4):205-11. doi: 10.1136/jme.2010.039057. Epub 2011 Jan 
      27.


PMID- 21278002
OWN - NLM
STAT- MEDLINE
DCOM- 20110830
LR  - 20151119
IS  - 1559-2030 (Electronic)
IS  - 1551-7144 (Linking)
VI  - 32
IP  - 3
DP  - 2011 May
TI  - Hospital training program increases awareness of Good Clinical Practice (GCP).
PG  - 339-41
LID - 10.1016/j.cct.2011.01.011 [doi]
AB  - OBJECTIVES: To develop an in-house training program of Good Clinical Practice
      (GCP) for the whole clinical team and to evaluate the effect of the program on
      the personnel's knowledge on GCP. BACKGROUND: GCP is a set of ethical and
      scientific quality requirements to which clinical trials must adhere. Since it is
      included in the legislation of the member states of European Union, it represents
      a challenge for research, and therefore more GCP training is needed. METHODS: At 
      the Department of Neurology and Rehabilitation, Tampere University Hospital,
      Finland, we developed an in-house GCP training program for the whole department, 
      including nurses. Before the training department staff was sent a questionnaire
      about their knowledge of and attitudes towards GCP as well as their perception of
      GCP compliance of studies being carried out at the Department. The subjects
      completed the questionnaire again after the training. RESULTS: Almost all, 95%,
      of the nurses and 50% of the physicians participated in the entire program. The
      program was found to increase positive attitudes towards GCP. CONCLUSION: A
      simple in-house training program is easy to implement and may help to improve GCP
      compliance.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Kuusisto, Hanna
AU  - Kuusisto H
AD  - Department of Neurology, Kanta-Hame Central Hospital, Tampere, Finland.
      hanna.kuusisto@khshp.fi
FAU - Virkki, Marjo
AU  - Virkki M
FAU - Wuolijoki, Erkki
AU  - Wuolijoki E
FAU - Keranen, Tapani
AU  - Keranen T
LA  - eng
PT  - Journal Article
DEP - 20110126
PL  - United States
TA  - Contemp Clin Trials
JT  - Contemporary clinical trials
JID - 101242342
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Clinical Trials as Topic/*methods/*standards
MH  - Education, Medical, Continuing
MH  - Education, Nursing, Continuing
MH  - Finland
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Medical Staff, Hospital/*education
MH  - Neurology
MH  - Nursing Staff, Hospital/*education
MH  - Physical and Rehabilitation Medicine
MH  - Pilot Projects
MH  - Professional Competence
MH  - Surveys and Questionnaires
EDAT- 2011/02/01 06:00
MHDA- 2011/08/31 06:00
CRDT- 2011/02/01 06:00
PHST- 2010/04/13 00:00 [received]
PHST- 2011/01/16 00:00 [revised]
PHST- 2011/01/17 00:00 [accepted]
PHST- 2011/02/01 06:00 [entrez]
PHST- 2011/02/01 06:00 [pubmed]
PHST- 2011/08/31 06:00 [medline]
AID - S1551-7144(11)00013-9 [pii]
AID - 10.1016/j.cct.2011.01.011 [doi]
PST - ppublish
SO  - Contemp Clin Trials. 2011 May;32(3):339-41. doi: 10.1016/j.cct.2011.01.011. Epub 
      2011 Jan 26.


PMID- 21277922
OWN - NLM
STAT- MEDLINE
DCOM- 20110623
LR  - 20211203
IS  - 1095-8304 (Electronic)
IS  - 0195-6663 (Linking)
VI  - 56
IP  - 2
DP  - 2011 Apr
TI  - Ethical and unethical food. Social representations among Finnish, Danish and
      Italian students.
PG  - 495-502
LID - 10.1016/j.appet.2011.01.023 [doi]
AB  - The consumption of ethical food is an area of major growth. The aim of the
      current study was to identify ethical concerns regarding food. University
      students (N=403) from Finland, Denmark and Italy completed a word association
      task, in which the given stimulus words were "ethical food" and "unethical food".
      The data was first analysed qualitatively. Next, the most relevant, core
      categories were identified based on the frequency, rank and contextual stability.
      The results indicated that fourteen categories reflect the content and nature of 
      ethical thinking with respect to food. The identified categories were
      required/prohibited food, natural/unnatural, local/global, healthy/unhealthy,
      equality/inequality, good animal welfare/poor animal welfare, rules and
      descriptions. In all countries, the core categories emerging from the stimulus
      word "ethical food" were the required food and the natural, while the core
      category identified from the stimulus word "unethical food" was the prohibited
      food. The most prevalent differences between the countries concerned the role of 
      health, country of origin and the descriptions. In conclusion, various ethical
      aspects are considered when food is evaluated in ethical terms, but the relevance
      of these aspects differ, even in the European context.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Makiniemi, Jaana-Piia
AU  - Makiniemi JP
AD  - University of Helsinki, Department of Social Research, Social Psychology,
      Unioninkatu 37, P.O. Box 54, 00014, University of Helsinki, Finland.
      jaana-piia.makiniemi@helsinki.fi
FAU - Pirttila-Backman, Anna-Maija
AU  - Pirttila-Backman AM
FAU - Pieri, Michelle
AU  - Pieri M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110126
PL  - England
TA  - Appetite
JT  - Appetite
JID - 8006808
SB  - IM
MH  - Adult
MH  - Cross-Cultural Comparison
MH  - Denmark
MH  - Evaluation Studies as Topic
MH  - Female
MH  - Finland
MH  - *Food
MH  - Food Preferences/*ethics
MH  - Humans
MH  - Italy
MH  - Male
MH  - Students
MH  - *Surveys and Questionnaires
MH  - *Whites
MH  - Young Adult
EDAT- 2011/02/01 06:00
MHDA- 2011/06/24 06:00
CRDT- 2011/02/01 06:00
PHST- 2010/07/22 00:00 [received]
PHST- 2010/12/30 00:00 [revised]
PHST- 2011/01/19 00:00 [accepted]
PHST- 2011/02/01 06:00 [entrez]
PHST- 2011/02/01 06:00 [pubmed]
PHST- 2011/06/24 06:00 [medline]
AID - S0195-6663(11)00040-7 [pii]
AID - 10.1016/j.appet.2011.01.023 [doi]
PST - ppublish
SO  - Appetite. 2011 Apr;56(2):495-502. doi: 10.1016/j.appet.2011.01.023. Epub 2011 Jan
      26.


PMID- 21276894
OWN - NLM
STAT- MEDLINE
DCOM- 20110601
LR  - 20110131
IS  - 1531-6564 (Electronic)
IS  - 0363-5023 (Linking)
VI  - 36
IP  - 2
DP  - 2011 Feb
TI  - The ethics of clinical research.
PG  - 308-15
LID - 10.1016/j.jhsa.2010.11.012 [doi]
AB  - The purpose of this article is to discuss the ethical concepts involved in the
      conception, design, execution, analysis, publication, and reporting of clinical
      research. Although it might seem burdensome to comply with these ethical
      necessities, they can assist in the organization of a well-run clinical trial, if
      considered at the onset of a study, while also protecting the valuable human
      subjects who volunteer for these trials.
CI  - Copyright (c) 2011 American Society for Surgery of the Hand. Published by
      Elsevier Inc. All rights reserved.
FAU - Chung, Kevin C
AU  - Chung KC
AD  - Section of Plastic Surgery, Department of Surgery, University of Michigan Health 
      System, Ann Arbor, MI 48109-0340, USA.kecchung@med.umich.edu
FAU - Kotsis, Sandra V
AU  - Kotsis SV
LA  - eng
GR  - K24AR053120/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - J Hand Surg Am
JT  - The Journal of hand surgery
JID - 7609631
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Clinical Trials as Topic/*ethics
MH  - Female
MH  - Humans
MH  - Male
MH  - Patient Selection/*ethics
MH  - Quality Control
MH  - Research Design
MH  - Safety Management
MH  - United States
EDAT- 2011/02/01 06:00
MHDA- 2011/06/02 06:00
CRDT- 2011/02/01 06:00
PHST- 2010/09/27 00:00 [received]
PHST- 2010/11/04 00:00 [revised]
PHST- 2010/11/08 00:00 [accepted]
PHST- 2011/02/01 06:00 [entrez]
PHST- 2011/02/01 06:00 [pubmed]
PHST- 2011/06/02 06:00 [medline]
AID - S0363-5023(10)01405-X [pii]
AID - 10.1016/j.jhsa.2010.11.012 [doi]
PST - ppublish
SO  - J Hand Surg Am. 2011 Feb;36(2):308-15. doi: 10.1016/j.jhsa.2010.11.012.


PMID- 31508069
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1749-3676 (Print)
IS  - 1749-3676 (Linking)
VI  - 8
IP  - 1
DP  - 2011 Feb
TI  - Getting your paper published.
PG  - 19-21
AB  - Embarking on a research project is always exciting, although a large number are
      not completed. One study of pharmacotherapy projects submitted to a research
      ethics committee found that after 5 years more than a quarter had not been
      completed and almost a sixth were considered unpublishable (Winther & Hole,
      1997).
FAU - Casey, Patricia
AU  - Casey P
AD  - Editor, The Psychiatrist, and Professor of Psychiatry, Mater Misericordiae
      University Hospital, Dublin, Ireland, email apsych@mater.ie.
LA  - eng
PT  - Journal Article
DEP - 20110201
PL  - England
TA  - Int Psychiatry
JT  - International psychiatry : bulletin of the Board of International Affairs of the 
      Royal College of Psychiatrists
JID - 101189664
PMC - PMC6735001
EDAT- 2011/02/01 00:00
MHDA- 2011/02/01 00:01
CRDT- 2019/09/12 06:00
PHST- 2019/09/12 06:00 [entrez]
PHST- 2011/02/01 00:00 [pubmed]
PHST- 2011/02/01 00:01 [medline]
PST - epublish
SO  - Int Psychiatry. 2011 Feb 1;8(1):19-21. eCollection 2011 Feb.


PMID- 30082934
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 0024-3639 (Print)
IS  - 0024-3639 (Linking)
VI  - 78
IP  - 1
DP  - 2011 Feb
TI  - Faith in Practice: End-of-Life Care and the Catholic Medical Professional.
PG  - 72-81
LID - 10.1179/002436311803888500 [doi]
AB  - Theological discussions on appropriate courses of care for the very ill can be
      more difficult if information on options and outcomes is lacking. This article
      provides an historical review of a change in the paradigm of care in the United
      States and similar developed countries. End-of-life courses can vary based on
      underlying disease processes and health system resources. The purpose of this
      article is to help readers to better appreciate the limitations of medicine, and 
      so be able to make a more informed decision about interventions that may be
      offered at the end of life. While there is also some discussion about ethics and 
      physician-assisted suicide, this is not intended to be a theological treatise on 
      Catholic doctrine related to the sanctity of life. Additionally, the following
      paragraphs will describe the current state of living and dying in America,
      contrast this with the way people wish to live until they die, discuss the role
      of the caregiver, provide insight into physician-assisted suicide and
      misconceptions about medicine, provide insight into the physician's role in
      end-of-life care, and explain what medicine can reasonably be expected to provide
      or prognosticate. Finally, there is an attempt to allay misconceptions about the 
      extent of the effect of medical interventions. Medical intervention is
      inextricably linked to human fallibility and shortcomings in clinical knowledge
      and achievement. Recognizing when human intervention can no longer provide cure, 
      prevent decline, or even slow the course of disease is crucial in making
      end-of-life care decisions.
FAU - Gloth, F Michael 3rd
AU  - Gloth FM 3rd
AD  - Johns Hopkins University School of Medicine.
LA  - eng
PT  - Journal Article
DEP - 20110201
PL  - United States
TA  - Linacre Q
JT  - The Linacre quarterly
JID - 2985221R
PMC - PMC6026953
EDAT- 2011/02/01 00:00
MHDA- 2011/02/01 00:01
CRDT- 2018/08/08 06:00
PHST- 2018/08/08 06:00 [entrez]
PHST- 2011/02/01 00:00 [pubmed]
PHST- 2011/02/01 00:01 [medline]
AID - 10.1179/002436311803888500 [doi]
AID - 10.1179_002436311803888500 [pii]
PST - ppublish
SO  - Linacre Q. 2011 Feb;78(1):72-81. doi: 10.1179/002436311803888500. Epub 2011 Feb
      1.


PMID- 30082933
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 0024-3639 (Print)
IS  - 0024-3639 (Linking)
VI  - 78
IP  - 1
DP  - 2011 Feb
TI  - Utilitarianism Impacting Care of those with Disabilities and those at Life's End.
PG  - 59-71
LID - 10.1179/002436311803888474 [doi]
AB  - Society's understanding of the nature of suffering impacts the development of
      health-care public policy, having a significant impact on care of the elderly and
      those with disabilities. With scientific advances comes a societal expectation
      that one can have "the perfect life," not just for one's self, but also for one's
      offspring. Thus extinguishing the imperfect life, at its earliest or later stages
      through physician-assisted suicide, becomes an accepted recourse. The Catholic
      tradition is rich in providing meaning to those who suffer and their families,
      particularly those at the end-of-life or those with disabilities. The Ethical and
      Religious Directives for Catholic Health Care Services address the importance of 
      advanced directives to assure that the health-care wishes of patients, no longer 
      able to express them, are respected. However, such directives cannot anticipate
      all of the health-care scenarios that could arise. Thus the role of a health-care
      agent (surrogate), who through extensive discussions knows the will of the
      patient and the mind of the Church, is critical. However, increasingly public
      policies, especially as they pertain to the allocation of costly resources such
      as health care, are impacting the health-care choices available to patients,
      their families, and the health-care provider. Consistent with the utilitarian
      ethic, state sanctioned killing of those deemed to have "lost their dignity" is
      hailed as a "good." This essay explores the challenges for all of us who are
      members of a profession once entrusted with protecting the most vulnerable among 
      us.
FAU - Hilliard, Marie T
AU  - Hilliard MT
AD  - National Catholic Bioethics Center, Philadelphia, Pennsylvania.
LA  - eng
PT  - Journal Article
DEP - 20110201
PL  - United States
TA  - Linacre Q
JT  - The Linacre quarterly
JID - 2985221R
PMC - PMC6026958
EDAT- 2011/02/01 00:00
MHDA- 2011/02/01 00:01
CRDT- 2018/08/08 06:00
PHST- 2018/08/08 06:00 [entrez]
PHST- 2011/02/01 00:00 [pubmed]
PHST- 2011/02/01 00:01 [medline]
AID - 10.1179/002436311803888474 [doi]
AID - 10.1179_002436311803888474 [pii]
PST - ppublish
SO  - Linacre Q. 2011 Feb;78(1):59-71. doi: 10.1179/002436311803888474. Epub 2011 Feb
      1.


PMID- 30082929
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 0024-3639 (Print)
IS  - 0024-3639 (Linking)
VI  - 78
IP  - 1
DP  - 2011 Feb
TI  - The Catholic Physician in an Era of Secular Bioethics.
PG  - 13-28
LID - 10.1179/002436311803888465 [doi]
AB  - This essay examines how commitment to the Roman Catholic moral and ethical
      traditions shapes the process, and content of bioethics and clinical decisions.
      An essential element of the vocation of Roman Catholic health professionals is to
      give genuine witness to that tradition in their daily clinical practices. Three
      questions will be addressed: 1) What is the justification for introducing
      religious commitments in clinical bioethics in a morally pluralist society? 2)
      What specifically does the Catholic medical tradition contribute to today's
      clinical decisions? 3) How are faith and reason to be balanced in clinical
      ethics? 4) Why are these questions relevant to papal calls for re-evangelization,
      or "re-proposal" of the faith, especially in the life of the physician?
FAU - Pellegrino, Edmund D
AU  - Pellegrino ED
AD  - Ethics, Georgetown University, Washington, D.C.
FAU - D'Arcy, Martin C
AU  - D'Arcy MC
AD  - Ethics, Georgetown University, Washington, D.C.
LA  - eng
PT  - Journal Article
DEP - 20110201
PL  - United States
TA  - Linacre Q
JT  - The Linacre quarterly
JID - 2985221R
PMC - PMC6026951
EDAT- 2011/02/01 00:00
MHDA- 2011/02/01 00:01
CRDT- 2018/08/08 06:00
PHST- 2018/08/08 06:00 [entrez]
PHST- 2011/02/01 00:00 [pubmed]
PHST- 2011/02/01 00:01 [medline]
AID - 10.1179/002436311803888465 [doi]
AID - 10.1179_002436311803888465 [pii]
PST - ppublish
SO  - Linacre Q. 2011 Feb;78(1):13-28. doi: 10.1179/002436311803888465. Epub 2011 Feb
      1.


PMID- 30082928
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 0024-3639 (Print)
IS  - 0024-3639 (Linking)
VI  - 78
IP  - 1
DP  - 2011 Feb
TI  - Perspectives on Directive 58.
PG  - 8-12
LID - 10.1179/002436311803888483 [doi]
AB  - The United States Conference of Catholic Bishops recently revised directive 58,
      on the use of artificial nutrition and hydration, in its Ethical and Religious
      Directives for Catholic Health Care Services. Although the revision clarifies
      that the use of artificial nutrition and hydration is ordinary, proportionate,
      and therefore, in principle, morally obligatory, the ethical debate surrounding
      this issue continues. Furthermore, many clinicians remain confused about the
      implications of this directive, as well as its application to specific cases.
      This article seeks to clarify both the implications and the practical application
      of directive 58, pointing out that providing artificial nutrition and hydration
      is part of normal care giving, and there are few instances in which such care can
      be licitly withheld or withdrawn from a patient.
FAU - Travaline, John M
AU  - Travaline JM
AD  - Temple University School of Medicine, Philadelphia.
FAU - Berg, Thomas V
AU  - Berg TV
AD  - St. Joseph's Seminary in Yonkers, New York.
LA  - eng
PT  - Journal Article
DEP - 20110201
PL  - United States
TA  - Linacre Q
JT  - The Linacre quarterly
JID - 2985221R
PMC - PMC6026952
EDAT- 2011/02/01 00:00
MHDA- 2011/02/01 00:01
CRDT- 2018/08/08 06:00
PHST- 2018/08/08 06:00 [entrez]
PHST- 2011/02/01 00:00 [pubmed]
PHST- 2011/02/01 00:01 [medline]
AID - 10.1179/002436311803888483 [doi]
AID - 10.1179_002436311803888483 [pii]
PST - ppublish
SO  - Linacre Q. 2011 Feb;78(1):8-12. doi: 10.1179/002436311803888483. Epub 2011 Feb 1.


PMID- 23914253
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1753-0350 (Print)
IS  - 1753-0350 (Linking)
VI  - 4
IP  - 1
DP  - 2011 Feb
TI  - 'Transport to Where?': Reflections on the problem of value and time a propos an
      awkward practice in medical research.
PG  - 45-64
AB  - Based upon Kenyan ethnography, this article examines the gap between the
      bioethics aversion to value transfers in clinical trials, and research
      participants' and researchers' expectations of these. This article focuses upon
      so-called 'transport reimbursement' (TR): monetary payments to participants that 
      are framed as mere refund of transport expenses, but which are of considerable
      value to recipients. The interest in this case lies not so much in the
      unsurprising gap between regulatory norms and poor study subjects' lives, but in 
      the way in which this discrepancy between bioethical discourse and materialities 
      of survival is silenced. In spite of the general awareness that TR indeed is
      about the material value of research, about value calculation, and expectations
      of return, it is not publicly discussed as such - unless ironically, in jest, or 
      in private. This double-blindness around 'reimbursement' has provoked discussions
      among ethicists and anthropologists, some of which propose that the work that
      generates scientific value should be recognised as labour and participants,
      accordingly, paid. Here, this paper argues that such a re-vision of trial
      participation as work rather than as a gift for the public good, risks abrogating
      the possibility of 'the public' that is not only a precondition of public medical
      science, but also its potential product. The supposedly radical solution of
      tearing away the veils of misrecognition that 'free' gifting ideology lays upon
      the realities of free labour, though analytically plausible, fails to recognise
      the utopian openings within clinical trial transactions that point beyond the
      present - towards larger forms of social association, and towards future
      alignments of scientific possibilities and human lives.
FAU - Geissler, P Wenzel
AU  - Geissler PW
AD  - Institute of Social Anthropology, University of Oslo, London ; London School of
      Hygiene and Tropical Medicine, London. Email: p.w.geissler@sai.uio.no ;
      wenzel.geissler@lshtm.ac.uk.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Cult Econ
JT  - Journal of cultural economy
JID - 101566121
PMC - PMC3729250
OTO - NOTNLM
OT  - Africa
OT  - Kenya
OT  - benefits
OT  - clinical trials
OT  - gift
OT  - money
OT  - research
OT  - value
EDAT- 2011/02/01 00:00
MHDA- 2011/02/01 00:01
CRDT- 2013/08/06 06:00
PHST- 2013/08/06 06:00 [entrez]
PHST- 2011/02/01 00:00 [pubmed]
PHST- 2011/02/01 00:01 [medline]
AID - 10.1080/17530350.2011.535335 [doi]
PST - ppublish
SO  - J Cult Econ. 2011 Feb;4(1):45-64. doi: 10.1080/17530350.2011.535335.


PMID- 23196313
OWN - NLM
STAT- MEDLINE
DCOM- 20131119
LR  - 20220211
IS  - 1998-3654 (Electronic)
IS  - 0019-5359 (Linking)
VI  - 65
IP  - 2
DP  - 2011 Feb
TI  - Assessment of use of complementary alternative medicine and its impact on quality
      of life in the patients attending rheumatology clinic, in a tertiary care centre 
      in India.
PG  - 50-7
AB  - PURPOSE: Complementary and alternative medicine (CAM) has witnessed an increase
      in use in recent times in rheumatological conditions and is expected to have
      impact on the quality of life (QOL). We had planned to conduct this study to
      investigate the extent of use of CAM and its effect on QOL of patients at a
      tertiary care center. MATERIALS AND METHODS: Ethics committee approval was
      obtained. Sixty patients suffering from osteoarthritis (OA) and rheumatoid
      arthritis (RA) were enrolled as per the selection criteria, after obtaining their
      informed consent. Each patient was interviewed for CAM use/non-use, and Western
      Ontario and McMaster Universities (WOMAC) (modified) index for QOL was recorded
      by the study personnel. STATISTICAL ANALYSIS: The normality was checked by using 
      Kolmogorov-Smirnov test. Descriptive statistics was performed and Mann-Whitney
      U-test was used to compare the QOL of CAM users and non-users. RESULTS: Of the 60
      patients enrolled with OA (10) and RA (50), 58% (35/60) used CAM. Ayurveda and
      massage therapy were the commonest [80% (28/35)], followed by yoga asana [34%
      (12/35)] and homoeopathy [20% (7/35)]. It was observed that combinations of
      therapies were used too. Nearly half [49% (17/35)] of the CAM users were on
      self-prescribed medication and 71% (25/35) of them did not inform the physician
      of CAM use. The QOL of CAM users (WOMAC score: 56.31 +/- 6.82) was better than
      that of CAM non-users (WOMAC score: 60.16 +/- 4.02) (P value 0.01). CONCLUSION:
      Patients with RA frequently used CAM and QOL improvised with CAM use. We observed
      that self-administration of CAM was common and this was not informed to the
      treating physician.
FAU - Jadhav, M P
AU  - Jadhav MP
AD  - Department of Infectious Diseases, Maharashtra University of Health Sciences,
      Seth G. S. Medical College and KEM Hospital, Parel, Mumbai, India.
FAU - Jadhav, P M
AU  - Jadhav PM
FAU - Shelke, P
AU  - Shelke P
FAU - Sharma, Y
AU  - Sharma Y
FAU - Nadkar, M
AU  - Nadkar M
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Sci
JT  - Indian journal of medical sciences
JID - 0373023
SB  - IM
MH  - Adult
MH  - Aged
MH  - Arthritis, Rheumatoid/epidemiology/*therapy
MH  - Complementary Therapies/*statistics & numerical data
MH  - Female
MH  - Humans
MH  - India/epidemiology
MH  - *Inpatients
MH  - Male
MH  - Middle Aged
MH  - Morbidity/trends
MH  - Osteoarthritis/epidemiology/*therapy
MH  - Patient Satisfaction
MH  - *Quality of Life
MH  - Surveys and Questionnaires
MH  - *Tertiary Healthcare
MH  - Treatment Outcome
EDAT- 2011/02/01 00:00
MHDA- 2013/11/20 06:00
CRDT- 2012/12/01 06:00
PHST- 2012/12/01 06:00 [entrez]
PHST- 2011/02/01 00:00 [pubmed]
PHST- 2013/11/20 06:00 [medline]
AID - IndianJMedSci_2011_65_2_50_103961 [pii]
PST - ppublish
SO  - Indian J Med Sci. 2011 Feb;65(2):50-7.


PMID- 22810793
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20120719
IS  - 1080-2371 (Print)
IS  - 1080-2371 (Linking)
VI  - 17
IP  - 1 Neurologic Complications of Systemic Disease
DP  - 2011 Feb
TI  - A young man with spinal muscular atrophy and impending respiratory arrest.
PG  - 148-51
LID - 10.1212/01.CON.0000394681.97867.b3 [doi]
AB  - From a statutory standpoint, the decision-making capacity of adolescents differs 
      significantly from that of adults because adolescents are considered to lack the 
      experience and judgment necessary to make legally binding decisions. Furthermore,
      in the case of minors, the principle of protection of life tends to outweigh the 
      principle of autonomy. Here we present the hypothetical case of a 16-year-old boy
      with spinalmuscular atrophy type II who was admitted to the intensive care unit
      for severe respiratory distress. We focus on the tension that developed among the
      patient, his parents, and his physicians when the need for emergency mechanical
      ventilation became apparent. We review the legal and ethical premises under which
      adolescents are permitted to make legally binding decisions, ie, the emancipated 
      minor and the mature minor doctrines. Finally, we discuss the concepts of
      protectionism and liberationism as they apply to adolescents' decision-making
      capacity.
FAU - Winters, Janine Penfield
AU  - Winters JP
FAU - Weisleder, Pedro
AU  - Weisleder P
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Continuum (Minneap Minn)
JT  - Continuum (Minneapolis, Minn.)
JID - 9509333
EDAT- 2011/02/01 00:00
MHDA- 2011/02/01 00:01
CRDT- 2012/07/20 06:00
PHST- 2012/07/20 06:00 [entrez]
PHST- 2011/02/01 00:00 [pubmed]
PHST- 2011/02/01 00:01 [medline]
AID - 10.1212/01.CON.0000394681.97867.b3 [doi]
AID - 00132979-201102000-00012 [pii]
PST - ppublish
SO  - Continuum (Minneap Minn). 2011 Feb;17(1 Neurologic Complications of Systemic
      Disease):148-51. doi: 10.1212/01.CON.0000394681.97867.b3.


PMID- 21274831
OWN - NLM
STAT- MEDLINE
DCOM- 20160423
LR  - 20181201
IS  - 0036-7281 (Print)
IS  - 0036-7281 (Linking)
VI  - 153
IP  - 2
DP  - 2011 Feb
TI  - Cloning of farm animals: impact on animal health and welfare and implications in 
      trade.
PG  - 57-62
LID - 10.1024/0036-7281/a000151 [doi]
AB  - The commercial use of animal cloning for breeding food producing animals has been
      limited so far by biological and technical constraints such as adverse effects on
      the health and welfare of animals, especially high perinatal and postnatal
      disease and mortality of clones. However, the improvement of the technique may
      overcome those problems in future and contribute to the spread of cloning in
      agricultural production, which raises concern not only on health and welfare
      aspects but also on food safety and ethics. This may cause conflict in
      international trade. The present article reviews these topics on the basis of
      up-to-date scientific opinions.
FAU - Menendez Gonzalez, S
AU  - Menendez Gonzalez S
AD  - Veterinary Public Health Institute, University of Berne.
FAU - Reist, M
AU  - Reist M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Switzerland
TA  - Schweiz Arch Tierheilkd
JT  - Schweizer Archiv fur Tierheilkunde
JID - 0424247
SB  - IM
MH  - Agriculture
MH  - Animal Husbandry
MH  - *Animal Welfare
MH  - Animals
MH  - *Animals, Domestic
MH  - Cloning, Molecular
EDAT- 2011/01/29 06:00
MHDA- 2016/04/24 06:00
CRDT- 2011/01/29 06:00
PHST- 2011/01/29 06:00 [entrez]
PHST- 2011/01/29 06:00 [pubmed]
PHST- 2016/04/24 06:00 [medline]
AID - 10.1024/0036-7281/a000151 [doi]
PST - ppublish
SO  - Schweiz Arch Tierheilkd. 2011 Feb;153(2):57-62. doi: 10.1024/0036-7281/a000151.


PMID- 21274748
OWN - NLM
STAT- MEDLINE
DCOM- 20110711
LR  - 20211020
IS  - 1573-6547 (Electronic)
IS  - 0278-095X (Linking)
VI  - 32
IP  - 1
DP  - 2011 Feb
TI  - Insurance and prevention: ethical aspects.
PG  - 3-15
LID - 10.1007/s10935-011-0234-z [doi]
AB  - In recent decades, prevention policies--i.e., insurance policies constructed to
      give incentives to investments in prevention and thereby reduce reliance on
      insurance--have been much discussed both with regard to different kinds of market
      insurance and, albeit primarily within a European context and in relation to an
      ongoing discussion about the need for a shift towards an "active" welfare state, 
      with regard to social insurance. The present contribution identifies normative
      issues that deserve attention in relation to a general introduction of prevention
      policies in market insurance and social insurance. It is argued that the
      importance of these normative issues suggests that arguments and distinctions
      drawn from moral and political philosophy should play a more prominent role both 
      in the debate on the shift towards an active welfare state and the use of
      prevention policies in market insurance.
FAU - Dubois, Mikael
AU  - Dubois M
AD  - Division of Philosophy, Royal Institute of Technology, Teknikringen 78B,
      Stockholm, Sweden. mikael.dubois@abe.kth.se
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Prim Prev
JT  - The journal of primary prevention
JID - 8213457
SB  - IM
CIN - J Prim Prev. 2011 Feb;32(1):17-21. PMID: 21308413
CIN - J Prim Prev. 2011 Feb;32(1):1-2. PMID: 21318466
MH  - Cross-Cultural Comparison
MH  - Environmental Health/economics/*ethics/methods
MH  - Europe
MH  - *Health Behavior
MH  - *Health Policy
MH  - Humans
MH  - Insurance Benefits/economics/ethics/standards
MH  - Insurance, Health/*ethics/standards
MH  - Motivation
MH  - Preventive Health Services/economics/*ethics/methods
MH  - Social Security/ethics/standards
MH  - United States
EDAT- 2011/01/29 06:00
MHDA- 2011/07/12 06:00
CRDT- 2011/01/29 06:00
PHST- 2011/01/29 06:00 [entrez]
PHST- 2011/01/29 06:00 [pubmed]
PHST- 2011/07/12 06:00 [medline]
AID - 10.1007/s10935-011-0234-z [doi]
PST - ppublish
SO  - J Prim Prev. 2011 Feb;32(1):3-15. doi: 10.1007/s10935-011-0234-z.


PMID- 21274635
OWN - NLM
STAT- MEDLINE
DCOM- 20111201
LR  - 20211020
IS  - 1573-3394 (Electronic)
IS  - 1065-3058 (Linking)
VI  - 19
IP  - 1
DP  - 2011 Mar
TI  - Ethics of care and responsibility: normative fragments.
PG  - 1-2
LID - 10.1007/s10728-011-0168-x [doi]
FAU - Nortvedt, Per
AU  - Nortvedt P
LA  - eng
PT  - Editorial
PT  - Introductory Journal Article
PL  - Netherlands
TA  - Health Care Anal
JT  - Health care analysis : HCA : journal of health philosophy and policy
JID - 9432537
MH  - Congresses as Topic
MH  - Delivery of Health Care/*ethics
MH  - Humans
PMC - PMC3037483
EDAT- 2011/01/29 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/01/29 06:00
PHST- 2011/01/29 06:00 [entrez]
PHST- 2011/01/29 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/s10728-011-0168-x [doi]
PST - ppublish
SO  - Health Care Anal. 2011 Mar;19(1):1-2. doi: 10.1007/s10728-011-0168-x.


PMID- 21273922
OWN - NLM
STAT- MEDLINE
DCOM- 20120529
LR  - 20110728
IS  - 1524-4040 (Electronic)
IS  - 0148-396X (Linking)
VI  - 68
IP  - 5
DP  - 2011 May
TI  - Autologous adult cortical cell transplantation enhances functional recovery
      following unilateral lesion of motor cortex in primates: a pilot study.
PG  - 1405-16; discussion 1416-7
LID - 10.1227/NEU.0b013e31820c02c0 [doi]
AB  - BACKGROUND: Although cell therapy is a promising approach after cerebral cortex
      lesion, few studies assess quantitatively its behavioral gain in nonhuman
      primates. Furthermore, implantations of fetal grafts of exogenous stem cells are 
      limited by safety and ethical issues. OBJECTIVE: To test in nonhuman primates the
      transplantation of autologous adult neural progenitor cortical cells with
      assessment of functional outcome. METHODS: Seven adult macaque monkeys were
      trained to perform a manual dexterity task, before the hand representation in
      motor cortex was chemically lesioned unilaterally. Five monkeys were used as
      control, compared with 2 monkeys subjected to different autologous cells
      transplantation protocols performed at different time intervals. RESULTS: After
      lesion, there was a complete loss of manual dexterity in the contralesional hand.
      The 5 "control" monkeys recovered progressively and spontaneously part of their
      manual dexterity, reaching a unique and definitive plateau of recovery, ranging
      from 38% to 98% of prelesion score after 10 to 120 days. The 2 "treated" monkeys 
      reached a first spontaneous recovery plateau at about 25 and 40 days postlesion, 
      representing 35% and 61% of the prelesion performance, respectively. In contrast 
      to the controls, a second recovery plateau took place 2 to 3 months after cell
      transplantation, corresponding to an additional enhancement of functional
      recovery, representing 24% and 37% improvement, respectively. CONCLUSIONS: These 
      pilot data, derived from 2 monkeys treated differently, suggest that, in the
      present experimental conditions, autologous adult brain progenitor cell
      transplantation in a nonhuman primate is safe and promotes enhancement of
      functional recovery.
FAU - Kaeser, Melanie
AU  - Kaeser M
AD  - Unit of Physiology, Department of Medicine, University of Fribourg, Fribourg,
      Switzerland.
FAU - Brunet, Jean-Francois
AU  - Brunet JF
FAU - Wyss, Alexander
AU  - Wyss A
FAU - Belhaj-Saif, Abderraouf
AU  - Belhaj-Saif A
FAU - Liu, Yu
AU  - Liu Y
FAU - Hamadjida, Adjia
AU  - Hamadjida A
FAU - Rouiller, Eric M
AU  - Rouiller EM
FAU - Bloch, Jocelyne
AU  - Bloch J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neurosurgery
JT  - Neurosurgery
JID - 7802914
SB  - IM
MH  - Animals
MH  - Cells, Cultured
MH  - Female
MH  - Macaca fascicularis
MH  - Male
MH  - Motor Cortex/*pathology/*surgery/transplantation
MH  - Pilot Projects
MH  - Psychomotor Performance/physiology
MH  - Recovery of Function/*physiology
MH  - Stem Cell Transplantation/*methods
MH  - Transplantation, Autologous
EDAT- 2011/01/29 06:00
MHDA- 2012/05/30 06:00
CRDT- 2011/01/29 06:00
PHST- 2011/01/29 06:00 [entrez]
PHST- 2011/01/29 06:00 [pubmed]
PHST- 2012/05/30 06:00 [medline]
AID - 10.1227/NEU.0b013e31820c02c0 [doi]
PST - ppublish
SO  - Neurosurgery. 2011 May;68(5):1405-16; discussion 1416-7. doi:
      10.1227/NEU.0b013e31820c02c0.


PMID- 21273523
OWN - NLM
STAT- MEDLINE
DCOM- 20110317
LR  - 20220310
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 258
IP  - 2
DP  - 2011 Feb
TI  - Liver fibrosis in patients with chronic hepatitis C: noninvasive diagnosis by
      means of real-time tissue elastography--establishment of the method for
      measurement.
PG  - 610-7
LID - 10.1148/radiol.10100319 [doi]
AB  - PURPOSE: To prospectively measure liver stiffness with real-time tissue
      elastography in patients with chronic hepatitis C and to compare the results with
      those of clinical assessment of fibrosis by using histologic stage as the
      reference standard. MATERIALS AND METHODS: All subjects gave informed consent,
      and the study was approved by the institutional ethics committee. Seventy
      hospitalized patients (46 men, 24 women; mean age, 65.5 years +/- 11.7 [standard 
      deviation]; age range, 33-87 years) with chronic hepatitis C underwent real-time 
      elastography between January 2009 and September 2009. Elastography was performed 
      at four liver locations by two independent observers. The elastic ratio (ratio of
      the value in the intrahepatic venous small vessels divided by the value in the
      hepatic parenchyma) was calculated and was compared with histologic fibrosis
      stage at liver biopsy. The elastic ratio and clinical fibrosis markers were
      assessed by using receiver operating characteristic (ROC) analysis. The
      differences between body site and observers were assessed with kappa statistics
      and intraclass correlation coefficients (ICCs). RESULTS: Real-time tissue
      elastography cutoff values were 2.73 for F of 2 or greater, 3.25 for F of 3 or
      greater, and 3.93 for F of 4. No site differences were observed (kappa = 0.835,
      ICC = 0.966), and the elastic ratio measurement was correlated between the two
      examiners (r(2) = 0.869, P < .0001). The areas under the ROC curves for elastic
      ratio, hyaluronic acid, type IV collagen, aspartate aminotransferase-to-platelet 
      ratio index, FibroIndex, Forns score, and Hepascore were 0.95, 0.32, 0.73, 0.76, 
      0.76, 0.87, and 0.70, respectively; the elastic ratio performed better than the
      serum fibrosis markers and other scores. CONCLUSION: Real-time tissue
      elastography is not invasive and could be used to evaluate liver fibrosis in
      patients with chronic hepatitis C. SUPPLEMENTAL MATERIAL:
      http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.10100319/-/DC1.
CI  - (c) RSNA, 2011
FAU - Koizumi, Yohei
AU  - Koizumi Y
AD  - Department of Gastroenterology and Metabology, Ehime University Graduate School
      of Medicine, Shitsukawa, Toon, Ehime 791-0295, Japan.
FAU - Hirooka, Masashi
AU  - Hirooka M
FAU - Kisaka, Yoshiyasu
AU  - Kisaka Y
FAU - Konishi, Ichiro
AU  - Konishi I
FAU - Abe, Masanori
AU  - Abe M
FAU - Murakami, Hidehiro
AU  - Murakami H
FAU - Matsuura, Bunzo
AU  - Matsuura B
FAU - Hiasa, Yoichi
AU  - Hiasa Y
FAU - Onji, Morikazu
AU  - Onji M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Elasticity Imaging Techniques/*methods
MH  - Female
MH  - Hepatitis C, Chronic/blood/*diagnostic imaging/pathology
MH  - Humans
MH  - Liver Cirrhosis/blood/*diagnostic imaging/pathology
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - ROC Curve
MH  - Sensitivity and Specificity
EDAT- 2011/01/29 06:00
MHDA- 2011/03/18 06:00
CRDT- 2011/01/29 06:00
PHST- 2011/01/29 06:00 [entrez]
PHST- 2011/01/29 06:00 [pubmed]
PHST- 2011/03/18 06:00 [medline]
AID - 258/2/610 [pii]
AID - 10.1148/radiol.10100319 [doi]
PST - ppublish
SO  - Radiology. 2011 Feb;258(2):610-7. doi: 10.1148/radiol.10100319.


PMID- 21273520
OWN - NLM
STAT- MEDLINE
DCOM- 20110317
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 258
IP  - 2
DP  - 2011 Feb
TI  - Reduction in false-positive results after introduction of digital mammography:
      analysis from four population-based breast cancer screening programs in Spain.
PG  - 388-95
LID - 10.1148/radiol.10100874 [doi]
AB  - PURPOSE: To evaluate the effect of the introduction of digital mammography on the
      recall rate, detection rate, false-positive rate, and rates of invasive
      procedures in a cohort of women from four population-based breast cancer
      screening programs in Spain. MATERIALS AND METHODS: The study was approved by the
      ethics committee; informed consent was not required. A total of 242,838
      mammograms (171,191 screen film [screen-film mammography group] and 71,647
      digital [digital mammography group]) obtained in 103,613 women aged 45-69 years
      were included. False-positive results for any additional procedure and for
      invasive procedures, the breast cancer rate, and the positive predictive value in
      each group were compared by using Pearson chi(2) test. The effect of the
      mammographic technology used (screen-film or digital) on the false-positive
      results and cancer detection risk was evaluated with multivariate logistic
      regression models, adjusted according to women's and the screening program's
      characteristics and time trends. RESULTS: The false-positive rate was higher for 
      screen-film than for digital mammography (7.6% and 5.7%, respectively; P < .001).
      False-positive results after an invasive procedure were significantly higher for 
      screen-film than for digital mammography (1.9% and 0.7%, respectively; P < .001).
      No significant differences were observed in the overall cancer detection rate
      between the two groups (0.45% and 0.43% in the screen-film and digital
      mammography groups, respectively; P = .59). The adjusted risk of a false-positive
      result was higher for screen-film than for digital mammography (odds ratio =
      1.32). The adjusted risk was also lower for the digital mammography group when
      time trends were taken into account. CONCLUSION: The lower false-positive risk
      with use of digital mammography should be taken into account when balancing the
      risks and benefits of breast cancer screening.
CI  - (c) RSNA, 2011.
FAU - Sala, Maria
AU  - Sala M
AD  - Health Services Evaluation and Clinical Epidemiology Department, IMIM-Hospital
      del Mar, CIBER Epidemiologia y Salud Publica, Passeig Maritim 25-29, 08008
      Barcelona, Spain. Msalaserra@hospitaldelmar.cat
FAU - Salas, Dolores
AU  - Salas D
FAU - Belvis, Francesc
AU  - Belvis F
FAU - Sanchez, Mar
AU  - Sanchez M
FAU - Ferrer, Joana
AU  - Ferrer J
FAU - Ibanez, Josefa
AU  - Ibanez J
FAU - Roman, Ruben
AU  - Roman R
FAU - Ferrer, Francisco
AU  - Ferrer F
FAU - Vega, Alfonso
AU  - Vega A
FAU - Laso, Maria Soledad
AU  - Laso MS
FAU - Castells, Xavier
AU  - Castells X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
EIN - Radiology. 2011 Jul;260(1):308
MH  - Aged
MH  - Breast Neoplasms/*diagnostic imaging/epidemiology
MH  - Chi-Square Distribution
MH  - False Positive Reactions
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Mammography/*methods
MH  - Mass Screening
MH  - Middle Aged
MH  - Radiographic Image Enhancement/methods
MH  - Spain/epidemiology
EDAT- 2011/01/29 06:00
MHDA- 2011/03/18 06:00
CRDT- 2011/01/29 06:00
PHST- 2011/01/29 06:00 [entrez]
PHST- 2011/01/29 06:00 [pubmed]
PHST- 2011/03/18 06:00 [medline]
AID - 258/2/388 [pii]
AID - 10.1148/radiol.10100874 [doi]
PST - ppublish
SO  - Radiology. 2011 Feb;258(2):388-95. doi: 10.1148/radiol.10100874.


PMID- 21272708
OWN - NLM
STAT- MEDLINE
DCOM- 20110302
LR  - 20181201
IS  - 1878-3570 (Electronic)
IS  - 0002-8223 (Linking)
VI  - 111
IP  - 2
DP  - 2011 Feb
TI  - Ethics opinion: eliminating dietetics-related inequalities.
PG  - 307-9
LID - 10.1016/j.jada.2010.12.010 [doi]
FAU - Fileti, Cecilia Pozo
AU  - Fileti CP
AD  - Latino Health Communications, Ann Arbor, MI, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Diet Assoc
JT  - Journal of the American Dietetic Association
JID - 7503061
SB  - IM
MH  - *Codes of Ethics
MH  - Dietetics/*ethics/standards
MH  - Ethics, Professional
MH  - *Health Status Disparities
MH  - Humans
MH  - Societies
MH  - United States
MH  - Workforce
EDAT- 2011/01/29 06:00
MHDA- 2011/03/03 06:00
CRDT- 2011/01/29 06:00
PHST- 2010/12/04 00:00 [received]
PHST- 2011/01/29 06:00 [entrez]
PHST- 2011/01/29 06:00 [pubmed]
PHST- 2011/03/03 06:00 [medline]
AID - S0002-8223(10)01992-9 [pii]
AID - 10.1016/j.jada.2010.12.010 [doi]
PST - ppublish
SO  - J Am Diet Assoc. 2011 Feb;111(2):307-9. doi: 10.1016/j.jada.2010.12.010.


PMID- 21272437
OWN - NLM
STAT- MEDLINE
DCOM- 20120918
LR  - 20170926
IS  - 1701-2163 (Print)
IS  - 1701-2163 (Linking)
VI  - 33
IP  - 1
DP  - 2011 Jan
TI  - Ethical decision making in the resuscitation of extremely premature infants: the 
      health care professional's perspective.
PG  - 49-56
LID - S1701-2163(16)34773-9 [pii]
LID - 10.1016/S1701-2163(16)34773-9 [doi]
AB  - Across Canada, the rate of preterm birth (i.e., at < 37 weeks' gestation) has
      been steadily increasing. Advances in perinatal medicine and neonatal intensive
      care have resulted in an increased capacity to intervene at the extremes of
      prematurity, leading to an increase in the overall survival of infants born at
      early gestations. There has been little corresponding decrease in long-term
      complications. As a result, additional stresses are placed on neonatal intensive 
      care units across the country, impacting families, health care professionals, and
      society as a whole. Moral distress and moral residue are often cited in the
      neonatal-perinatal literature as stressors experienced by those who participate
      in the resuscitation decision-making process. They are directly related to the
      challenge of making a concrete decision about life and death at extremely early
      gestations in the context of long-term uncertainty. In this review, we performed 
      a systematic search of medical and ethics literature pertaining to resuscitation 
      at the extremes of prematurity. The perspective of health care professionals is
      explored, including how definitions of viability and parental perspectives
      contribute to the decision-making process. We argue for the necessity of further 
      research exploring the inter-professional context of ethical decision making at
      the extremes of prematurity.
FAU - Weir, Mark
AU  - Weir M
AD  - Health and Rehabilitation Sciences, Faculty of Health Sciences, University of
      Western Ontario, London ON.
FAU - Evans, Marilyn
AU  - Evans M
AD  - School of Nursing, Faculty of Health Sciences, University of Western Ontario,
      London ON.
FAU - Coughlin, Kevin
AU  - Coughlin K
AD  - Division of Neonatal-Perinatal Medicine, Department of Paediatrics, University of
      Western Ontario, London ON.
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - J Obstet Gynaecol Can
JT  - Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et
      gynecologie du Canada : JOGC
JID - 101126664
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Decision Making/*ethics
MH  - Humans
MH  - Infant, Newborn
MH  - *Infant, Premature
MH  - Premature Birth/*therapy
MH  - Resuscitation/*ethics
EDAT- 2011/01/29 06:00
MHDA- 2012/09/19 06:00
CRDT- 2011/01/29 06:00
PHST- 2011/01/29 06:00 [entrez]
PHST- 2011/01/29 06:00 [pubmed]
PHST- 2012/09/19 06:00 [medline]
AID - S1701-2163(16)34773-9 [pii]
AID - 10.1016/S1701-2163(16)34773-9 [doi]
PST - ppublish
SO  - J Obstet Gynaecol Can. 2011 Jan;33(1):49-56. doi: 10.1016/S1701-2163(16)34773-9.


PMID- 21272336
OWN - NLM
STAT- MEDLINE
DCOM- 20110610
LR  - 20220129
IS  - 1471-2288 (Electronic)
IS  - 1471-2288 (Linking)
VI  - 11
DP  - 2011 Jan 27
TI  - Response to written feedback of clinical data within a longitudinal study: a
      qualitative study exploring the ethical implications.
PG  - 10
LID - 10.1186/1471-2288-11-10 [doi]
AB  - BACKGROUND: There is a growing ethical imperative to feedback research results to
      participants but there remains a striking lack of empirical research on how
      people respond to individualised feedback. We sought to explore longitudinal
      study participants' response to receiving individual written feedback of
      weight-related and blood results, and to consider the balance of harms against
      benefits. METHODS: A qualitative study with face-to-face and telephone interviews
      conducted with 50 men and women who had participated in the fifth and most recent
      wave of the cohort study 'West of Scotland Twenty-07' and received a feedback
      letter containing body mass index (BMI), body fat percentage, cholesterol and
      glycated haemoglobin A1c (HbA1c) results. RESULTS: Expectations of, and response 
      to, the feedback of their individual results varied. Whilst half of the
      participants were on the whole 'pleased' with their results or held neutral
      views, half reported negative responses such as 'shock' or 'concern',
      particularly in relation to the weight-related results. Participants who were
      overweight and obese used the most negative language about their results, with
      some being quite distressed and reporting feelings of powerlessness, low
      self-image and anxiety over future health. Nevertheless, some people reported
      having implemented lifestyle changes in direct response to the feedback,
      resulting in significant weight-loss and/or dietary improvements. Others reported
      being motivated to change their behaviour. Age and gender differences were
      apparent in these narratives of behaviour change. CONCLUSIONS: The potential harm
      caused to some participants may be balanced against the benefit to others. More
      evaluation of the impact of the format, content and means of individualised
      feedback of research findings in non-trial studies is required given the growing 
      ethical imperative to offer participants a choice of receiving their results, and
      the likelihood that a high percentage will choose to receive them.
FAU - Lorimer, Karen
AU  - Lorimer K
AD  - MRC/CSO Social and Public Health Sciences Unit, 4 Lilybank Gardens, Glasgow G12
      8RZ, UK.
FAU - Gray, Cindy M
AU  - Gray CM
FAU - Hunt, Kate
AU  - Hunt K
FAU - Wyke, Sally
AU  - Wyke S
FAU - Anderson, Annie
AU  - Anderson A
FAU - Benzeval, Michaela
AU  - Benzeval M
LA  - eng
GR  - MC_U130059811/MRC_/Medical Research Council/United Kingdom
GR  - C10677/A15032/CRUK_/Cancer Research UK/United Kingdom
GR  - WBS U.1300.80.001.00001/MRC_/Medical Research Council/United Kingdom
GR  - MC_UP_A540_1021/MRC_/Medical Research Council/United Kingdom
GR  - MC_U130085862/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110127
PL  - England
TA  - BMC Med Res Methodol
JT  - BMC medical research methodology
JID - 100968545
RN  - 0 (Glycated Hemoglobin A)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Adipose Tissue
MH  - Adult
MH  - Anxiety/psychology
MH  - Body Mass Index
MH  - Cholesterol/blood
MH  - *Ethics, Research
MH  - *Feedback, Psychological
MH  - Female
MH  - Glycated Hemoglobin A/analysis
MH  - Humans
MH  - Longitudinal Studies/*ethics
MH  - Male
MH  - Middle Aged
MH  - Research Report
MH  - Risk Assessment
MH  - Truth Disclosure
PMC - PMC3041784
EDAT- 2011/01/29 06:00
MHDA- 2011/06/11 06:00
CRDT- 2011/01/29 06:00
PHST- 2010/09/21 00:00 [received]
PHST- 2011/01/27 00:00 [accepted]
PHST- 2011/01/29 06:00 [entrez]
PHST- 2011/01/29 06:00 [pubmed]
PHST- 2011/06/11 06:00 [medline]
AID - 1471-2288-11-10 [pii]
AID - 10.1186/1471-2288-11-10 [doi]
PST - epublish
SO  - BMC Med Res Methodol. 2011 Jan 27;11:10. doi: 10.1186/1471-2288-11-10.


PMID- 21272296
OWN - NLM
STAT- MEDLINE
DCOM- 20110505
LR  - 20220408
IS  - 1471-2288 (Electronic)
IS  - 1471-2288 (Linking)
VI  - 11
IP  - 1
DP  - 2011 Jan 27
TI  - Developing a Dementia Research Registry: a descriptive case study from North
      Thames DeNDRoN and the EVIDEM programme.
PG  - 9
LID - 10.1186/1471-2288-11-9 [doi]
AB  - AIM: To describe the development of a dementia research registry, outlining the
      conceptual, practical and ethical challenges, and to report initial experiences
      of recruiting people with dementia to it from primary and secondary care.
      BACKGROUND: Women, the oldest old and ethnic minorities have been
      under-represented in clinical trials in dementia. Such under-representation
      biases estimates of absolute effect, absolute harm and cost-effectiveness.
      Research on dementia should include patient populations that more exactly reflect
      the population at risk. One of the impediments to this is the lack of a suitable 
      tool for identification of patients suitable for studies. CONSTRUCTION &
      CONTENTS: A technology development methodology was used to develop a registry of 
      people with dementia and their carers. This involved phases of modelling and
      prototype creation, 'bench testing' the prototype with experts and then 'field
      testing' the refined prototype in exemplar sites. The evaluation of the field
      testing described here is based on a case study methodology. UTILITY: This case
      study suggests that construction and population of a dementia research registry
      is feasible, but initial development is complex because of the ethical and
      organisational difficulties. Recruitment from primary care is particularly costly
      in terms of staff time and only identifies a very small number of people with
      dementia who were not already known to specialist services. Recruiting people
      with dementia through secondary care is a resource intensive process that takes
      up to six months to complete. Identifying the components of a minimum dataset was
      easy but its usefulness for pre-screening potential research populations has yet 
      to be established. Acceptance rates are very high in the first clinic to recruit 
      to the registry, but this may reflect the efforts of registry 'champions'.
      DISCUSSION AND CONCLUSIONS: Easier recruitment may perpetuate potential selection
      biases and we are not yet able to assess the representativeness of the
      research-ready population recruited to the registry. The need to recruit from
      wider populations, through primary and social care, remains. The success of this 
      registry will be measured by the proportion of people from it who are recruited
      to research projects, and its impact on overall accrual to studies.
FAU - Iliffe, Steve
AU  - Iliffe S
AD  - Research Department of Primary Care & Population Health, University College
      London, Royal Free campus, Rowland Hill St., London NW3 2PF, UK.
      s.iliffe@ucl.ac.uk
FAU - Curry, Lisa
AU  - Curry L
FAU - Kharicha, Kalpa
AU  - Kharicha K
FAU - Rait, Greta
AU  - Rait G
FAU - Wilcock, Jane
AU  - Wilcock J
FAU - Lowery, David
AU  - Lowery D
FAU - Tapuria, Archana
AU  - Tapuria A
FAU - Kalra, Dipak
AU  - Kalra D
FAU - Ritchie, Craig
AU  - Ritchie C
LA  - eng
GR  - MC_U122797163/MRC_/Medical Research Council/United Kingdom
GR  - RP-PG-0606-1005/DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110127
PL  - England
TA  - BMC Med Res Methodol
JT  - BMC medical research methodology
JID - 100968545
SB  - IM
MH  - *Caregivers
MH  - Confidentiality
MH  - *Dementia
MH  - Female
MH  - Humans
MH  - *Patient Selection
MH  - *Registries
MH  - United Kingdom
PMC - PMC3038162
EDAT- 2011/01/29 06:00
MHDA- 2011/05/06 06:00
CRDT- 2011/01/29 06:00
PHST- 2010/10/21 00:00 [received]
PHST- 2011/01/27 00:00 [accepted]
PHST- 2011/01/29 06:00 [entrez]
PHST- 2011/01/29 06:00 [pubmed]
PHST- 2011/05/06 06:00 [medline]
AID - 1471-2288-11-9 [pii]
AID - 10.1186/1471-2288-11-9 [doi]
PST - epublish
SO  - BMC Med Res Methodol. 2011 Jan 27;11(1):9. doi: 10.1186/1471-2288-11-9.


PMID- 21271595
OWN - NLM
STAT- MEDLINE
DCOM- 20110308
LR  - 20131106
IS  - 1531-4995 (Electronic)
IS  - 0023-852X (Linking)
VI  - 121
IP  - 2
DP  - 2011 Feb
TI  - Sensorineural hearing loss in sickle cell disease--a prospective study from Oman.
PG  - 392-6
LID - 10.1002/lary.21374 [doi]
AB  - BACKGROUND: Sickle cell disease (SCD) is characterized by intermittent episodes
      of vascular occlusion and end-organ damage. Neurologic symptoms are frequent and 
      auditory involvement is not unexpected. AIM: To study the prevalence and pattern 
      of hearing loss in Omani patients with SCD. METHODS: We conducted a prospective
      case control study on SCD patients attending the outpatient department. Age and
      sex matched normal volunteer blood donor controls were recruited after an
      informed consent and Medical Ethics Committee approval. Pure tone audiometry was 
      performed in all cases studied. RESULTS: Forty-six SCD patients (15 males, 32.6%)
      aged 16-45 years with a mean age of 26 years +/- 6.9 and 29 controls (10 males,
      34.4%) aged 16-39 years with a mean age of 25.24 +/- 8.2 were enrolled in this
      study. The average hearing thresholds of SCD patients were consistently higher
      than controls in all frequencies tested in both ears. Of the 92 ears tested in
      SCD patients, 29.34% had SNHL. Ten patients had bilateral SNHL; whereas 3 and 4
      cases had SNHL in left and right ears, respectively. All the control subjects had
      hearing thresholds within normal limits. SUMMARY/CONCLUSIONS: The study reveals a
      significant incidence of sensorineural hearing loss (SNHL) in SCD patients
      (36.95%), although the patients were clinically asymptomatic. The hearing loss
      was worse in the right ears and had a female preponderance. Also, the hearing
      loss was more severe at the higher frequencies, 2,000-8,000 Hz in SCD patients.
      HbS, HbF, or low hemoglobin levels did not discriminate SCD patients with SNHL,
      and the role of hemoglobin F in the cochlea is still not clear. Regular
      audiometric assessment should therefore be recommended in SCD patients routinely.
CI  - Copyright (c) 2010 The American Laryngological, Rhinological, and Otological
      Society, Inc.
FAU - Al Okbi, Muhammed Hesham
AU  - Al Okbi MH
AD  - Department of ENT, Sultan Qaboos University Hospital, Alkud, Muscat, Oman.
      al_okbi@hotmail.com
FAU - Alkindi, Salam
AU  - Alkindi S
FAU - Al Abri, Rashid K
AU  - Al Abri RK
FAU - Mathew, John
AU  - Mathew J
FAU - Nagwa, Afarida A
AU  - Nagwa AA
FAU - Pathare, Anil V
AU  - Pathare AV
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anemia, Sickle Cell/*complications
MH  - Audiometry
MH  - Female
MH  - Hearing Loss, Sensorineural/*etiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oman
MH  - Prospective Studies
MH  - Sex Factors
EDAT- 2011/01/29 06:00
MHDA- 2011/03/09 06:00
CRDT- 2011/01/29 06:00
PHST- 2011/01/29 06:00 [entrez]
PHST- 2011/01/29 06:00 [pubmed]
PHST- 2011/03/09 06:00 [medline]
AID - 10.1002/lary.21374 [doi]
PST - ppublish
SO  - Laryngoscope. 2011 Feb;121(2):392-6. doi: 10.1002/lary.21374.


PMID- 21271499
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20110707
IS  - 1439-3522 (Electronic)
IS  - 0720-4299 (Linking)
VI  - 79
IP  - 7
DP  - 2011 Jul
TI  - [Hormone-based classification and therapy concepts in psychiatry].
PG  - 384-94
LID - 10.1055/s-0031-1273489 [doi]
AB  - This study retells key aspects of the history of the idea of hormone-based
      classification and therapy concepts in psychiatry. Different contributions to the
      history are not only represented from a historical, but also from a current
      medico-scientific perspective. One of the oldest, yet ethically most problematic,
      indications concerning hormonal methods to modify undesirable behaviour and
      sexuality was castration, which was widely used in the 20th century to "cure"
      homosexuality. Felix Platter, whose concept was humoral-pathological in nature,
      documented the first postpartum psychosis in the German-speaking countries, the
      pathogenesis of which according to present-day expertise is brought about by
      changes in female hormones. The concept of an "endocrine psychiatry" was
      developed at the beginning of the 20th century. Some protagonists for
      neuroendocrinology are highlighted, such as Paul Julius Mobius around 1900 or, in
      the 1950s, Manfred Bleuler, the nestor of this new discipline. Only the discovery
      of the hormones as such and the development of technologies like radioimmunassay 
      to measure and quantify these hormone changes in mental illnesses allowed
      investigating these conditions properly. Ever since hormone-based therapeutic and
      classification concepts have played an important role, above all, in sexual,
      affective and eating disorders as well as alcohol dependence.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Himmerich, H
AU  - Himmerich H
AD  - Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Medizinische Fakultat
      der Universitat Leipzig.
FAU - Steinberg, H
AU  - Steinberg H
LA  - ger
PT  - English Abstract
PT  - Historical Article
PT  - Journal Article
PT  - Review
TT  - Hormonelle Krankheits- und Therapiekonzepte in der Psychiatrie.
DEP - 20110126
PL  - Germany
TA  - Fortschr Neurol Psychiatr
JT  - Fortschritte der Neurologie-Psychiatrie
JID - 8103137
RN  - 0 (Hormones)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Castration
MH  - Depression, Postpartum/physiopathology/therapy
MH  - Endocrinology/history
MH  - Female
MH  - History, 20th Century
MH  - Hormones/analysis/*physiology/therapeutic use
MH  - Humans
MH  - Mental Disorders/*classification/drug therapy/*physiopathology
MH  - Pregnancy
MH  - Psychiatry/*history
EDAT- 2011/01/29 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/01/29 06:00
PHST- 2011/01/29 06:00 [entrez]
PHST- 2011/01/29 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - 10.1055/s-0029-1245779 [doi]
PST - ppublish
SO  - Fortschr Neurol Psychiatr. 2011 Jul;79(7):384-94. doi: 10.1055/s-0029-1245779.
      Epub 2011 Jan 26.


PMID- 21269778
OWN - NLM
STAT- MEDLINE
DCOM- 20110722
LR  - 20110422
IS  - 1879-1409 (Electronic)
IS  - 0305-4179 (Linking)
VI  - 37
IP  - 4
DP  - 2011 Jun
TI  - Evaluation of amniotic fluid as a skin graft storage media compared with RPMI and
      saline.
PG  - 652-5
LID - 10.1016/j.burns.2010.11.008 [doi]
AB  - We aimed to assess and compare the histological changes of grafts stored in
      Roswell Park Memorial Institute-1640 solution (RPMI), amniotic fluid (AF), and
      saline. Amniotic fluid which has abundant nutrients, proteins, and growth
      factors, and antimicrobial features may be an easily achievable and cheap
      alternative for the short term preservation of skin grafts. Discarded surgical
      skin pieces obtained from 15 trauma patients were divided into three groups as
      RPMI, AF, and saline. The specimens were evaluated at days 7, 14, 21, and 28 for 
      histological alterations by a 3-point scoring scale. Histological scores in the
      grafts stored in amniotic fluid and RPMI were found significantly lower than
      those stored in saline (p<0.01). No significant difference was detected between
      AF and RPMI stored grafts. AF may be a good alternative for skin graft
      preservation as demonstrated by histological changes. New studies with multiple
      AF donators and repeated experiments will be worthwhile. Besides, restrictions of
      some ethical and legal issues for AF use should be solved.
CI  - Copyright (c) 2010 Elsevier Ltd and ISBI. All rights reserved.
FAU - Turhan-Haktanir, Nurten
AU  - Turhan-Haktanir N
AD  - Department of Plastic, Reconstructive, and Aesthetic Surgery, Afyonkarahisar
      Kocatepe University, Faculty of Medicine, Afyonkarahisar, Turkey.
      nurth70@yahoo.com
FAU - Dilek, F Husniye
AU  - Dilek FH
FAU - Koken, Gulengul
AU  - Koken G
FAU - Demir, Yavuz
AU  - Demir Y
FAU - Yilmaz, Guray
AU  - Yilmaz G
LA  - eng
PT  - Journal Article
DEP - 20110126
PL  - Netherlands
TA  - Burns
JT  - Burns : journal of the International Society for Burn Injuries
JID - 8913178
RN  - 0 (Organ Preservation Solutions)
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - *Amniotic Fluid
MH  - Collagen/analysis
MH  - Fibroblasts/pathology
MH  - Humans
MH  - *Organ Preservation Solutions
MH  - *Skin/pathology
MH  - Skin Transplantation/methods
MH  - Tissue Preservation/*methods
EDAT- 2011/01/29 06:00
MHDA- 2011/07/23 06:00
CRDT- 2011/01/29 06:00
PHST- 2010/02/22 00:00 [received]
PHST- 2010/10/15 00:00 [revised]
PHST- 2010/11/06 00:00 [accepted]
PHST- 2011/01/29 06:00 [entrez]
PHST- 2011/01/29 06:00 [pubmed]
PHST- 2011/07/23 06:00 [medline]
AID - S0305-4179(10)00294-9 [pii]
AID - 10.1016/j.burns.2010.11.008 [doi]
PST - ppublish
SO  - Burns. 2011 Jun;37(4):652-5. doi: 10.1016/j.burns.2010.11.008. Epub 2011 Jan 26.


PMID- 21269473
OWN - NLM
STAT- MEDLINE
DCOM- 20110419
LR  - 20220316
IS  - 1755-8794 (Electronic)
IS  - 1755-8794 (Linking)
VI  - 4
DP  - 2011 Jan 26
TI  - The eMERGE Network: a consortium of biorepositories linked to electronic medical 
      records data for conducting genomic studies.
PG  - 13
LID - 10.1186/1755-8794-4-13 [doi]
AB  - INTRODUCTION: The eMERGE (electronic MEdical Records and GEnomics) Network is an 
      NHGRI-supported consortium of five institutions to explore the utility of DNA
      repositories coupled to Electronic Medical Record (EMR) systems for advancing
      discovery in genome science. eMERGE also includes a special emphasis on the
      ethical, legal and social issues related to these endeavors. ORGANIZATION: The
      five sites are supported by an Administrative Coordinating Center. Setting of
      network goals is initiated by working groups: (1) Genomics, (2) Informatics, and 
      (3) Consent & Community Consultation, which also includes active participation by
      investigators outside the eMERGE funded sites, and (4) Return of Results
      Oversight Committee. The Steering Committee, comprised of site PIs and
      representatives and NHGRI staff, meet three times per year, once per year with
      the External Scientific Panel. CURRENT PROGRESS: The primary site-specific
      phenotypes for which samples have undergone genome-wide association study (GWAS) 
      genotyping are cataract and HDL, dementia, electrocardiographic QRS duration,
      peripheral arterial disease, and type 2 diabetes. A GWAS is also being undertaken
      for resistant hypertension in approximately 2,000 additional samples identified
      across the network sites, to be added to data available for samples already
      genotyped. Funded by ARRA supplements, secondary phenotypes have been added at
      all sites to leverage the genotyping data, and hypothyroidism is being analyzed
      as a cross-network phenotype. Results are being posted in dbGaP. Other key eMERGE
      activities include evaluation of the issues associated with cross-site deployment
      of common algorithms to identify cases and controls in EMRs, data privacy of
      genomic and clinically-derived data, developing approaches for large-scale
      meta-analysis of GWAS data across five sites, and a community consultation and
      consent initiative at each site. FUTURE ACTIVITIES: Plans are underway to expand 
      the network in diversity of populations and incorporation of GWAS findings into
      clinical care. SUMMARY: By combining advanced clinical informatics, genome
      science, and community consultation, eMERGE represents a first step in the
      development of data-driven approaches to incorporate genomic information into
      routine healthcare delivery.
FAU - McCarty, Catherine A
AU  - McCarty CA
FAU - Chisholm, Rex L
AU  - Chisholm RL
FAU - Chute, Christopher G
AU  - Chute CG
FAU - Kullo, Iftikhar J
AU  - Kullo IJ
FAU - Jarvik, Gail P
AU  - Jarvik GP
FAU - Larson, Eric B
AU  - Larson EB
FAU - Li, Rongling
AU  - Li R
FAU - Masys, Daniel R
AU  - Masys DR
FAU - Ritchie, Marylyn D
AU  - Ritchie MD
FAU - Roden, Dan M
AU  - Roden DM
FAU - Struewing, Jeffery P
AU  - Struewing JP
FAU - Wolf, Wendy A
AU  - Wolf WA
CN  - eMERGE Team
LA  - eng
GR  - U01-HG-004610/HG/NHGRI NIH HHS/United States
GR  - U01-HG-04603/HG/NHGRI NIH HHS/United States
GR  - U01 HG004603/HG/NHGRI NIH HHS/United States
GR  - U01HG004609/HG/NHGRI NIH HHS/United States
GR  - U01 HG004609/HG/NHGRI NIH HHS/United States
GR  - U01 HG004599/HG/NHGRI NIH HHS/United States
GR  - U01 HG004609-03/HG/NHGRI NIH HHS/United States
GR  - U01 HG004610/HG/NHGRI NIH HHS/United States
GR  - U01-HG-004608/HG/NHGRI NIH HHS/United States
GR  - U01 HG004608/HG/NHGRI NIH HHS/United States
GR  - U01-HG-04599/HG/NHGRI NIH HHS/United States
PT  - Letter
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110126
PL  - England
TA  - BMC Med Genomics
JT  - BMC medical genomics
JID - 101319628
SB  - IM
MH  - American Recovery and Reinvestment Act
MH  - Clinical Trials as Topic/*methods
MH  - Diabetes Mellitus, Type 2/genetics
MH  - *Electronic Health Records
MH  - *Genome
MH  - Genome-Wide Association Study
MH  - Genotype
MH  - Humans
MH  - Hypertension/genetics
MH  - National Human Genome Research Institute (U.S.)
MH  - Peripheral Arterial Disease/genetics
MH  - *Population Groups
MH  - United States
PMC - PMC3038887
IR  - McCarty CA
FIR - McCarty, Catherine A
IR  - Starren J
FIR - Starren, Justin
IR  - Peissig P
FIR - Peissig, Peggy
IR  - Berg R
FIR - Berg, Richard
IR  - Rasmussen L
FIR - Rasmussen, Luke
IR  - Linneman J
FIR - Linneman, James
IR  - Miller A
FIR - Miller, Aaron
IR  - Choudary V
FIR - Choudary, Vidhu
IR  - Chen L
FIR - Chen, Lin
IR  - Waudby C
FIR - Waudby, Carol
IR  - Kitchner T
FIR - Kitchner, Terrie
IR  - Reeser J
FIR - Reeser, Jonathan
IR  - Fost N
FIR - Fost, Norman
IR  - Ritchie M
FIR - Ritchie, Marylyn
IR  - Wilke RA
FIR - Wilke, Russell A
IR  - Chisholm RL
FIR - Chisholm, Rex L
IR  - Avila PC
FIR - Avila, Pedro C
IR  - Greenland P
FIR - Greenland, Philip
IR  - Hayes MG
FIR - Hayes, M Geoff
IR  - Kho A
FIR - Kho, Abel
IR  - Kibbe WA
FIR - Kibbe, Warren A
IR  - Lemke AA
FIR - Lemke, Amy A
IR  - Lowe WL
FIR - Lowe, William L
IR  - Smith ME
FIR - Smith, Maureen E
IR  - Wolf WA
FIR - Wolf, Wendy A
IR  - Pacheco JA
FIR - Pacheco, Jennifer A
IR  - Thompson WK
FIR - Thompson, William K
IR  - Humowiecki J
FIR - Humowiecki, Joel
IR  - Law M
FIR - Law, May
IR  - Chute C
FIR - Chute, Christopher
IR  - Kullo I
FIR - Kullo, Iftikar
IR  - Koenig B
FIR - Koenig, Barbara
IR  - de Andrade M
FIR - de Andrade, Mariza
IR  - Bielinski S
FIR - Bielinski, Suzette
IR  - Pathak J
FIR - Pathak, Jyotishman
IR  - Savova G
FIR - Savova, Guergana
IR  - Wu J
FIR - Wu, Joel
IR  - Henriksen J
FIR - Henriksen, Joan
IR  - Ding K
FIR - Ding, Keyue
IR  - Hart L
FIR - Hart, Lacey
IR  - Palbicki J
FIR - Palbicki, Jeremy
IR  - Larson EB
FIR - Larson, Eric B
IR  - Newton K
FIR - Newton, Katherine
IR  - Ludman E
FIR - Ludman, Evette
IR  - Spangler L
FIR - Spangler, Leslie
IR  - Hart G
FIR - Hart, Gene
IR  - Carrell D
FIR - Carrell, David
IR  - Jarvik G
FIR - Jarvik, Gail
IR  - Crane P
FIR - Crane, Paul
IR  - Burke W
FIR - Burke, Wylie
IR  - Fullerton SM
FIR - Fullerton, Stephanie Malia
IR  - Trinidad SB
FIR - Trinidad, Susan Brown
IR  - Carlson C
FIR - Carlson, Chris
IR  - McDavid A
FIR - McDavid, Andrew
IR  - Roden DM
FIR - Roden, Dan M
IR  - Clayton E
FIR - Clayton, Ellen
IR  - Haines JL
FIR - Haines, Jonathan L
IR  - Masys DR
FIR - Masys, Daniel R
IR  - Churchill LR
FIR - Churchill, Larry R
IR  - Cornfield D
FIR - Cornfield, Daniel
IR  - Crawford D
FIR - Crawford, Dana
IR  - Darbar D
FIR - Darbar, Dawood
IR  - Denny JC
FIR - Denny, Joshua C
IR  - Malin BA
FIR - Malin, Bradley A
IR  - Ritchie MD
FIR - Ritchie, Marylyn D
IR  - Schildcrout JS
FIR - Schildcrout, Jonathan S
IR  - Xu H
FIR - Xu, Hua
IR  - Ramirez AH
FIR - Ramirez, Andrea Havens
IR  - Basford M
FIR - Basford, Melissa
IR  - Pulley J
FIR - Pulley, Jill
EDAT- 2011/01/29 06:00
MHDA- 2011/04/20 06:00
CRDT- 2011/01/29 06:00
PHST- 2010/02/05 00:00 [received]
PHST- 2011/01/26 00:00 [accepted]
PHST- 2011/01/29 06:00 [entrez]
PHST- 2011/01/29 06:00 [pubmed]
PHST- 2011/04/20 06:00 [medline]
AID - 1755-8794-4-13 [pii]
AID - 10.1186/1755-8794-4-13 [doi]
PST - epublish
SO  - BMC Med Genomics. 2011 Jan 26;4:13. doi: 10.1186/1755-8794-4-13.


PMID- 21267797
OWN - NLM
STAT- MEDLINE
DCOM- 20110915
LR  - 20211020
IS  - 0973-7693 (Electronic)
IS  - 0019-5456 (Linking)
VI  - 78
IP  - 5
DP  - 2011 May
TI  - Determinants of health related quality of life in school-going adolescents in
      Northern India.
PG  - 555-61
LID - 10.1007/s12098-010-0305-9 [doi]
AB  - OBJECTIVE: To identify determinants of good Health Related Quality of Life
      (HRQoL) in school going adolescents. METHODS: This Cross-sectional study was
      conducted in public and private schools in Lucknow, Northern India after
      obtaining institutional ethical clearance. Children aged 10 to 19 years were
      included after obtaining parental written informed consent. HRQoL was assessed
      using culturally appropriate WHOQOL-BREF version. RESULTS: From 1900 schools in
      Lucknow, 10 public and 10 private schools were selected. Within schools, random
      selection of the subjects was done. Dropout rate was 7.2% (525/566). Mean age of 
      participants was 14.04 +/- 2.09 years, of which 52.4% (275/525) were boys and
      48.5% (255/525) were from private schools. Good HRQoL was a score >/=83, which
      corresponded to third quartile, and 33.7% and 16.6% of subjects, from private and
      public schools, respectively, fell in this category (p-value <0.0001).
      Determinants of good HRQoL on multivariate analysis were age <14 years (OR: 2.11,
      95%CI 1.39-3.02, p < 0.0001) and studying in private school (OR = 2.04, 95%CI
      1.18-3.51, p < 0.0001). CONCLUSIONS: Younger adolescent age and enrolment in
      private schools are determinants of good HRQoL in school-going adolescents.
      Further research is needed to identify measures to improve HRQoL among older
      adolescents and those studying in public schools.
FAU - Awasthi, Shally
AU  - Awasthi S
AD  - Department of Pediatrics, Chattrapati Shahuji Maharaj Medical University
      (Erstwhile King George's Medical University), Shahmina Road, Lucknow, (UP)
      226003, India. shallya@rediffmail.com
FAU - Agnihotri, Kasturi
AU  - Agnihotri K
FAU - Singh, Uttam
AU  - Singh U
FAU - Thakur, Savitri
AU  - Thakur S
FAU - Chandra, Hem
AU  - Chandra H
LA  - eng
PT  - Journal Article
DEP - 20110126
PL  - India
TA  - Indian J Pediatr
JT  - Indian journal of pediatrics
JID - 0417442
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Child
MH  - Cross-Sectional Studies
MH  - Female
MH  - *Health Status
MH  - Humans
MH  - India
MH  - Male
MH  - *Quality of Life
MH  - Schools
MH  - Students
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2011/01/27 06:00
MHDA- 2011/09/16 06:00
CRDT- 2011/01/27 06:00
PHST- 2010/10/05 00:00 [received]
PHST- 2010/11/23 00:00 [accepted]
PHST- 2011/01/27 06:00 [entrez]
PHST- 2011/01/27 06:00 [pubmed]
PHST- 2011/09/16 06:00 [medline]
AID - 10.1007/s12098-010-0305-9 [doi]
PST - ppublish
SO  - Indian J Pediatr. 2011 May;78(5):555-61. doi: 10.1007/s12098-010-0305-9. Epub
      2011 Jan 26.


PMID- 21267659
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20211020
IS  - 1573-3394 (Electronic)
IS  - 1065-3058 (Linking)
VI  - 19
IP  - 4
DP  - 2011 Dec
TI  - The doctor and the market: about the influence of market reforms on the
      professional medical ethics of surgeons and general practitioners in the
      Netherlands.
PG  - 388-402
LID - 10.1007/s10728-011-0166-z [doi]
AB  - To explore whether market reforms in a health care system affect medical
      professional ethics of hospital-based specialists on the one hand and physicians 
      in independent practices on the other. Qualitative interviews with 27 surgeons
      and 28 general practitioners in The Netherlands, held 2-3 years after a major
      overhaul of the Dutch health care system involving several market reforms.
      Surgeons now regularly advertise their work (while this was forbidden in the
      past) and pay more attention to patients with relatively minor afflictions, thus 
      deviating from codes of ethics that oblige physicians to treat each other as
      brothers and to treat patients according to medical need. Dutch GPs have
      abandoned their traditional reticence and their fear of medicalization. They now 
      seem to treat more in accordance with patients' preferences and less in
      accordance with medical need. Market reforms do affect medical professional
      principles, and it is doubtful whether these changes were intended when Dutch
      policy makers decided to introduce market elements in the health care system.
      Policy makers in other countries considering similar reforms should pay attention
      to these results.
FAU - Dwarswaard, Jolanda
AU  - Dwarswaard J
AD  - Erasmus University, Campus Woudestein, Rotterdam, The Netherlands.
      dwarswaard@bmg.eur.nl
FAU - Hilhorst, Medard
AU  - Hilhorst M
FAU - Trappenburg, Margo
AU  - Trappenburg M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Health Care Anal
JT  - Health care analysis : HCA : journal of health philosophy and policy
JID - 9432537
MH  - Adult
MH  - Attitude of Health Personnel
MH  - *Ethics, Medical
MH  - General Practitioners/*ethics
MH  - General Surgery/*ethics
MH  - Health Care Reform
MH  - Humans
MH  - Male
MH  - Medical Staff, Hospital/*ethics
MH  - Middle Aged
MH  - Netherlands
MH  - Qualitative Research
PMC - PMC3212676
EDAT- 2011/01/27 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/01/27 06:00
PHST- 2011/01/27 06:00 [entrez]
PHST- 2011/01/27 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - 10.1007/s10728-011-0166-z [doi]
PST - ppublish
SO  - Health Care Anal. 2011 Dec;19(4):388-402. doi: 10.1007/s10728-011-0166-z.


PMID- 21267571
OWN - NLM
STAT- MEDLINE
DCOM- 20120821
LR  - 20211020
IS  - 1437-160X (Electronic)
IS  - 0172-8172 (Linking)
VI  - 32
IP  - 5
DP  - 2012 May
TI  - Pain intensity and quality of life perception in children with hypermobility
      syndrome.
PG  - 1277-84
LID - 10.1007/s00296-010-1729-2 [doi]
AB  - Hypermobility syndrome (HMS) is a major source of morbidity in children. Impaired
      quality of life (QoL) has been observed recently in adults with HMS; however,
      this issue is yet to be investigated in children with this condition. This study 
      compared pain intensity and QoL in children with HMS with healthy controls. It
      also examined the relationship between pain intensity and QoL in children with
      HMS. Following ethical approval, 29 children diagnosed with HMS and 37 healthy
      children aged 8-15 years participated. Informed written consent was obtained from
      participants and their parents/guardians. Average knee pain over the past week
      was examined using the Coloured Analogue Scale. QoL was measured via the
      Pediatric Quality of Life Inventory. Mann-Whitney U tests were performed to
      compare pain and QoL scores between the two groups. Spearman Rho correlation
      analysis was performed to examine the relationship between pain and QoL. Overall 
      QoL scores in each domain were significantly lower in children with HMS (all p < 
      0.001) compared with the controls. Pain intensity was significantly higher in
      children with HMS compared with their healthy counterparts (p < 0.001). A strong 
      negative correlation was observed between pain intensity and overall QoL and all 
      the domains (r range = -0.614 to -0.717; all p < 0.001). In conclusion, the
      findings of the present study imply that pain and QoL assessment might form
      important components of clinical examination for children diagnosed with HMS.
      These children may benefit from appropriate treatment programmes to alleviate
      pain intensity and improve QoL.
FAU - Fatoye, Francis
AU  - Fatoye F
AD  - Department of Health Professions, School of Health, Psychology and Social Care,
      Manchester Metropolitan University, Elizabeth Gaskell Campus, Hathersage Road,
      Manchester, M13 0JA, UK. f.fatoye@mmu.ac.uk
FAU - Palmer, Shea
AU  - Palmer S
FAU - Macmillan, Fiona
AU  - Macmillan F
FAU - Rowe, Philip
AU  - Rowe P
FAU - van der Linden, Marietta
AU  - van der Linden M
LA  - eng
PT  - Journal Article
DEP - 20110126
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Arthralgia/diagnosis/*etiology/physiopathology/psychology
MH  - Case-Control Studies
MH  - Child
MH  - Cost of Illness
MH  - Cross-Sectional Studies
MH  - Humans
MH  - Joint Instability/*complications/diagnosis/physiopathology/psychology
MH  - Knee Joint/*physiopathology
MH  - Pain Measurement
MH  - *Perception
MH  - Predictive Value of Tests
MH  - *Quality of Life
MH  - Scotland
MH  - Self Report
MH  - Severity of Illness Index
MH  - Syndrome
EDAT- 2011/01/27 06:00
MHDA- 2012/08/22 06:00
CRDT- 2011/01/27 06:00
PHST- 2010/06/24 00:00 [received]
PHST- 2010/12/30 00:00 [accepted]
PHST- 2011/01/27 06:00 [entrez]
PHST- 2011/01/27 06:00 [pubmed]
PHST- 2012/08/22 06:00 [medline]
AID - 10.1007/s00296-010-1729-2 [doi]
PST - ppublish
SO  - Rheumatol Int. 2012 May;32(5):1277-84. doi: 10.1007/s00296-010-1729-2. Epub 2011 
      Jan 26.


PMID- 21267026
OWN - NLM
STAT- MEDLINE
DCOM- 20110328
LR  - 20191210
IS  - 0807-7096 (Electronic)
IS  - 0029-2001 (Linking)
VI  - 131
IP  - 2
DP  - 2011 Jan 21
TI  - Is the discussion of patient cases in clinical ethics-committees useful?
PG  - 118-21
LID - 10.4045/tidsskr.10.0183 [doi]
AB  - BACKGROUND: All health enterprises in Norway today have at least one clinical
      ethics committee (CEC). One of the aims is to give advice and to counsel the
      hospital staff on ethical issues. As part of the quality assurance of this work, 
      we wanted to find out if clinicians have benefited from these committees in
      individual cases. MATERIAL AND METHODOLOGY: The local committees were requested
      to distribute a questionnaire to all clinicians who had submitted a case to the
      committee during the previous 18 months. The survey was anonymous. Out of the 86 
      questionnaires that were distributed, 43 (50%) were returned to the Centre for
      Medical Ethics. RESULTS: The majority of clinicians had a number of reasons for
      contacting the committee. The most usual reason was the desire to have a broad
      consultation on a case (70%), which was regarded as useful. The most common issue
      discussed was limiting the treatment of a seriously ill patient (56%), the
      will/wishes of the next-of-kin (40%) and patient autonomy (37%). The committee
      gave advice in 50% of the cases. Thirty-eight percent of the consultations
      resulted in practical consequences, including the discontinuation of treatment in
      six cases. INTERPRETATION: Because of the low response percentage, the results
      must be interpreted with caution. The work of the committees is generally
      evaluated as useful, and the consultations can have practical consequences.
      However, it is challenging to make this work better known among clinicians and to
      conduct quality assurance.
FAU - Kalager, Guro
AU  - Kalager G
AD  - Centre for Medical Ethics, University of Oslo, Postbox 1130 Blindern, 0318 Oslo, 
      Norway.
FAU - Forde, Reidun
AU  - Forde R
FAU - Pedersen, Reidar
AU  - Pedersen R
LA  - eng
LA  - nor
PT  - Journal Article
PL  - Norway
TA  - Tidsskr Nor Laegeforen
JT  - Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny
      raekke
JID - 0413423
SB  - IM
CIN - Tidsskr Nor Laegeforen. 2011 Jan 21;131(2):108. PMID: 21267017
MH  - Communication
MH  - Conflict, Psychological
MH  - *Ethics Committees, Clinical/standards/statistics & numerical data
MH  - *Ethics Consultation
MH  - *Ethics, Clinical
MH  - Humans
MH  - Norway
MH  - Patient Participation
MH  - Quality Assurance, Health Care
MH  - Surveys and Questionnaires
EDAT- 2011/01/27 06:00
MHDA- 2011/03/29 06:00
CRDT- 2011/01/27 06:00
PHST- 2011/01/27 06:00 [entrez]
PHST- 2011/01/27 06:00 [pubmed]
PHST- 2011/03/29 06:00 [medline]
AID - 2065863 [pii]
AID - 10.4045/tidsskr.10.0183 [doi]
PST - ppublish
SO  - Tidsskr Nor Laegeforen. 2011 Jan 21;131(2):118-21. doi: 10.4045/tidsskr.10.0183.


PMID- 21267017
OWN - NLM
STAT- MEDLINE
DCOM- 20110328
LR  - 20110126
IS  - 0807-7096 (Electronic)
IS  - 0029-2001 (Linking)
VI  - 131
IP  - 2
DP  - 2011 Jan 21
TI  - [Clinical ethics committees--time for changes?].
PG  - 108
LID - 10.4045/tidsskr.10.1012 [doi]
FAU - Ekeberg, Oivind
AU  - Ekeberg O
LA  - nor
PT  - Comment
PT  - Editorial
TT  - Komiteer for klinisk etikk--tid for endringer?
PL  - Norway
TA  - Tidsskr Nor Laegeforen
JT  - Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny
      raekke
JID - 0413423
SB  - IM
CON - Tidsskr Nor Laegeforen. 2011 Jan 21;131(2):118-21. PMID: 21267026
MH  - *Ethics Committees, Clinical
MH  - *Ethics, Clinical
MH  - Europe
MH  - Norway
EDAT- 2011/01/27 06:00
MHDA- 2011/03/29 06:00
CRDT- 2011/01/27 06:00
PHST- 2011/01/27 06:00 [entrez]
PHST- 2011/01/27 06:00 [pubmed]
PHST- 2011/03/29 06:00 [medline]
AID - 2065111 [pii]
AID - 10.4045/tidsskr.10.1012 [doi]
PST - ppublish
SO  - Tidsskr Nor Laegeforen. 2011 Jan 21;131(2):108. doi: 10.4045/tidsskr.10.1012.


PMID- 21266895
OWN - NLM
STAT- MEDLINE
DCOM- 20110525
LR  - 20191210
IS  - 1538-1145 (Electronic)
IS  - 1527-4160 (Linking)
VI  - 17
IP  - 1
DP  - 2011 Jan
TI  - Addressing impairment in a colleague.
PG  - 53-6
LID - 10.1097/01.pra.0000393845.56217.69 [doi]
AB  - It is an anguishing experience for a professional community to deal with a
      colleague's impairment. This column is the outgrowth of a recent workshop in a
      multidisciplinary psychoanalytic center focused on the ethical, technical, and
      humane dimensions of that situation. A hypothetical case history was used to
      stimulate discussion of issues related to clinical evidence of impairment,
      protection of patients/clients, the role of aging in observers as well as the
      observed, denial and wishful thinking that may delay intervention, how to
      intervene, and duties imposed by the various health professional licensing
      boards. The discussion also focused on the effects of impairment and intervention
      on confidential psychotherapeutic relationships and process as well as on
      personal friendships, monitoring colleagues dealing with impairments, and the
      resources for response within the professional community such as assistance and
      ethics committees. (Journal of Psychiatric Practice 2011;17:53-56).
FAU - Clemens, Norman A
AU  - Clemens NA
AD  - Department of Psychiatry, faculty of the Cleveland Psychoanalytic Center, Case
      Western Reserve University School of Medicine, Cleveland, Ohio, USA.
FAU - Horwitz, Marc
AU  - Horwitz M
FAU - Sharp, Janet
AU  - Sharp J
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Psychiatr Pract
JT  - Journal of psychiatric practice
JID - 100901141
SB  - IM
MH  - Aging/psychology
MH  - Denial, Psychological
MH  - Fatigue/complications
MH  - Health Personnel/*psychology
MH  - Humans
MH  - Ischemic Attack, Transient/complications
MH  - Male
MH  - Professional Impairment/*psychology
MH  - Psychotherapy/ethics
EDAT- 2011/01/27 06:00
MHDA- 2011/05/26 06:00
CRDT- 2011/01/27 06:00
PHST- 2011/01/27 06:00 [entrez]
PHST- 2011/01/27 06:00 [pubmed]
PHST- 2011/05/26 06:00 [medline]
AID - 10.1097/01.pra.0000393845.56217.69 [doi]
AID - 00131746-201101000-00007 [pii]
PST - ppublish
SO  - J Psychiatr Pract. 2011 Jan;17(1):53-6. doi: 10.1097/01.pra.0000393845.56217.69.


PMID- 21266893
OWN - NLM
STAT- MEDLINE
DCOM- 20110525
LR  - 20110126
IS  - 1538-1145 (Electronic)
IS  - 1527-4160 (Linking)
VI  - 17
IP  - 1
DP  - 2011 Jan
TI  - Learning from losing: ethical, psychoanalytic, and spiritual perspectives on
      managing the incremental losses of the distributed self in dementia.
PG  - 41-8
LID - 10.1097/01.pra.0000393843.71464.dc [doi]
AB  - The author describes his experiences making decisions about the care of his
      mother, who was suffering from dementia, and the profound effect this process had
      on him as a psychotherapist. As background, he first presents an overview of
      writings from Jerry M. Lewis, George Pollock, and George Vaillant on issues
      related to attachment, death, loss, and mourning. The author equates his
      experiences caring for his mother with a type of involuntary "continuing
      education" and describes the lessons he learned as he was faced with decisions
      about his mother's level of care and as he mourned the slow, piecemeal loss of
      her distributed self. A case vignette is presented to illustrate how the author
      applied the lessons he had learned in psychotherapy with a distressed patient
      caring for her aging mother. The article concludes with a summary of the clinical
      and ethical questions raised by this case and the author's experience with his
      mother and a discussion of principles that can help psychotherapists provide
      treatment for patients who are caring for family members with dementia. (Journal 
      of Psychiatric Practice. 2011;17:41-48).
FAU - Lomax, James W
AU  - Lomax JW
AD  - Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of
      Medicine, Houston, TX, USA. jlomax@bcm.edu
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Psychiatr Pract
JT  - Journal of psychiatric practice
JID - 100901141
SB  - IM
MH  - Adaptation, Psychological
MH  - Attitude to Death
MH  - Dementia/*psychology
MH  - *Ego
MH  - *Ethics, Medical
MH  - Female
MH  - *Grief
MH  - Humans
MH  - *Learning
MH  - Middle Aged
MH  - Mothers/psychology
MH  - Psychoanalysis
MH  - *Spirituality
MH  - Withholding Treatment
EDAT- 2011/01/27 06:00
MHDA- 2011/05/26 06:00
CRDT- 2011/01/27 06:00
PHST- 2011/01/27 06:00 [entrez]
PHST- 2011/01/27 06:00 [pubmed]
PHST- 2011/05/26 06:00 [medline]
AID - 10.1097/01.pra.0000393843.71464.dc [doi]
AID - 00131746-201101000-00005 [pii]
PST - ppublish
SO  - J Psychiatr Pract. 2011 Jan;17(1):41-8. doi: 10.1097/01.pra.0000393843.71464.dc.


PMID- 21266388
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20110524
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 6
DP  - 2011 Jun
TI  - Parents' experiences of newborn screening for genetic susceptibility to type 1
      diabetes.
PG  - 348-53
LID - 10.1136/jme.2010.039206 [doi]
AB  - Advances in genomic medicine have lead to debate about the potential inclusion of
      genetic tests for susceptibility to common complex disorders in newborn screening
      programmes. Empirical evidence concerning psychosocial reactions to genetic
      testing is a crucial component of both ethical debate and policy development, but
      while there has been much speculation concerning the possible psychosocial impact
      of screening newborns for genetic susceptibilities, there remains a paucity of
      data. The aim of the study reported here is to provide some of this missing
      empirical evidence, using type 1 diabetes as an example of a common disorder with
      multiple significant genetic contributors to its aetiology. Semi-structured
      interviews were conducted with 11 parents of babies who had received increased
      risk results in a study that involved newborn screening for genetic
      susceptibility to type 1 diabetes. Interpretative phenomenological analysis was
      used to evaluate the data. The interview data suggest that the probabilistic
      nature of results of genetic susceptibility tests impacts upon all aspects of
      parents' psychosocial reactions, resulting in a complex and dynamic process quite
      different to that described in relation to current newborn screening programmes. 
      While parents generally reported fairly minor levels of concern in response to
      news of their child's increased genetic risk, these worries frequently recurred, 
      and perception of risk also varied and fluctuated over time. Both individual and 
      contextual factors appeared to interact with the inherent uncertainty of the test
      result to contribute to the dynamic nature of parental reactions, and their
      behavioural responses. The implications of these findings for future research and
      for the debate concerning potential expansion of newborn screening are discussed.
FAU - Kerruish, Nikki J
AU  - Kerruish NJ
AD  - Department of Paediatrics, University of Otago, Dunedin, New Zealand.
      nikki.kerruish@stonebow.otago.ac.nz
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110125
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Adult
MH  - Child, Preschool
MH  - Diabetes Mellitus, Type 1/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease/*psychology
MH  - *Genetic Testing
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - Middle Aged
MH  - Neonatal Screening/methods/*psychology
MH  - Parents/*psychology
MH  - Pregnancy
MH  - Risk Assessment
EDAT- 2011/01/27 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/01/27 06:00
PHST- 2011/01/27 06:00 [entrez]
PHST- 2011/01/27 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - jme.2010.039206 [pii]
AID - 10.1136/jme.2010.039206 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Jun;37(6):348-53. doi: 10.1136/jme.2010.039206. Epub 2011 Jan 
      25.


PMID- 21266385
OWN - NLM
STAT- MEDLINE
DCOM- 20110523
LR  - 20110318
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 4
DP  - 2011 Apr
TI  - Ethical issues related to the access to orphan drugs in Brazil: the case of
      mucopolysaccharidosis type I.
PG  - 233-9
LID - 10.1136/jme.2010.037150 [doi]
AB  - BACKGROUND/AIMS: Mucopolysaccharidosis type I (MPS I) is a rare lysosomal storage
      disorder treated with bone marrow transplantation or enzyme replacement therapy
      with laronidase, a high-cost orphan drug. Laronidase was approved by the US Food 
      and Drug Administration and the European Medicines Agency in 2003 and by the
      Brazilian National Health Surveillance Agency in 2005. Many Brazilian MPS I
      patients have been receiving laronidase despite the absence of a governmental
      policy regulating access to the drug. Epidemiological and treatment data
      concerning MPS I are scarce. This study aims to present a demographic profile of 
      Brazilian patients with MPS I, describe the routes of access to laronidase in
      Brazil, and discuss associated ethical issues relating to public funding of
      orphan drugs. METHODS: In this cross-sectional observational study, data were
      collected nationwide between January and September 2008 from physicians, public
      institutions and non-governmental organisations involved with diagnosis and
      treatment of MPS I, using two data collection instruments specifically designed
      for this purpose. RESULTS: The minimum prevalence of MPS I in Brazil was
      estimated at 1/2,700,000. Most patients (69.8%) were younger than 15 years; 60
      (88.2%) received laronidase. The most common route of access to the drug was
      through lawsuits (86.6%). CONCLUSIONS: In Brazil, MPS I is predominantly a
      paediatric illness. Even though the cost of laronidase treatment is not
      officially covered by the Brazilian government, most MPS I patients receive the
      drug, usually through litigation. This gives rise to major ethical conflicts
      concerning drug access in a low-resource context. The Brazilian health policy
      framework lacks evidence-based clinical protocols for the distribution of orphan 
      drugs.
FAU - Boy, Raquel
AU  - Boy R
AD  - Servico de Genetica Medica, Hospital de Clinicas de Porto Alegre, Rua Ramiro
      Barcelos, 2350, CEP 90035-003, Porto Alegre, RS, Brazil.
FAU - Schwartz, Ida V D
AU  - Schwartz IV
FAU - Krug, Barbara C
AU  - Krug BC
FAU - Santana-da-Silva, Luiz C
AU  - Santana-da-Silva LC
FAU - Steiner, Carlos E
AU  - Steiner CE
FAU - Acosta, Angelina X
AU  - Acosta AX
FAU - Ribeiro, Erlane M
AU  - Ribeiro EM
FAU - Galera, Marcial F
AU  - Galera MF
FAU - Leivas, Paulo G C
AU  - Leivas PG
FAU - Braz, Marlene
AU  - Braz M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110125
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
RN  - EC 3.2.1.76 (Iduronidase)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged, 80 and over
MH  - Brazil
MH  - Child
MH  - Child, Preschool
MH  - Drug Costs/ethics/*legislation & jurisprudence
MH  - Female
MH  - Health Policy/economics
MH  - Humans
MH  - Iduronidase/economics/supply & distribution/*therapeutic use
MH  - Infant
MH  - Male
MH  - Middle Aged
MH  - Mucopolysaccharidosis I/*drug therapy/economics
MH  - Orphan Drug Production/*economics/ethics/legislation & jurisprudence
MH  - Young Adult
EDAT- 2011/01/27 06:00
MHDA- 2011/05/24 06:00
CRDT- 2011/01/27 06:00
PHST- 2011/01/27 06:00 [entrez]
PHST- 2011/01/27 06:00 [pubmed]
PHST- 2011/05/24 06:00 [medline]
AID - jme.2010.037150 [pii]
AID - 10.1136/jme.2010.037150 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Apr;37(4):233-9. doi: 10.1136/jme.2010.037150. Epub 2011 Jan
      25.


PMID- 21266076
OWN - NLM
STAT- MEDLINE
DCOM- 20110411
LR  - 20211020
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 12
DP  - 2011 Jan 25
TI  - Access and use of human tissues from the developing world: ethical challenges and
      a way forward using a tissue trust.
PG  - 2
LID - 10.1186/1472-6939-12-2 [doi]
AB  - BACKGROUND: Scientists engaged in global health research are increasingly faced
      with barriers to access and use of human tissues from the developing world
      communities where much of their research is targeted. In part, the problem can be
      traced to distrust of researchers from affluent countries, given the history of
      'scientific-imperialism' and 'biocolonialism' reflected in past well publicized
      cases of exploitation of research participants from low to middle income
      countries. DISCUSSION: To a considerable extent, the failure to adequately engage
      host communities, the opacity of informed consent, and the lack of fair
      benefit-sharing have played a significant role in eroding trust. These ethical
      considerations are central to biomedical research in low to middle income
      countries and failure to attend to them can inadvertently contribute to
      exploitation and erode trust. A 'tissue trust' may be a plausible means for
      enabling access to human tissues for research in a manner that is responsive to
      the ethical challenges considered. SUMMARY: Preventing exploitation and restoring
      trust while simultaneously promoting global health research calls for innovative 
      approaches to human tissues research. A tissue trust can reduce the risk of
      exploitation and promote host capacity as a key benefit.
FAU - Emerson, Claudia I
AU  - Emerson CI
AD  - McLaughlin-Rotman Centre for Global Health, University Health Network &
      University of Toronto, 101 College Street, Suite 406, Toronto, Ontario, M5G 1L7, 
      Canada. claudia.emerson@mrcglobal.org
FAU - Singer, Peter A
AU  - Singer PA
FAU - Upshur, Ross E G
AU  - Upshur RE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110125
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Biomedical Research/*ethics
MH  - *Community-Based Participatory Research/ethics
MH  - *Developing Countries
MH  - Humans
MH  - *Informed Consent/ethics
MH  - *Tissue Banks/ethics
MH  - Trust
PMC - PMC3038983
EDAT- 2011/01/27 06:00
MHDA- 2011/04/13 06:00
CRDT- 2011/01/27 06:00
PHST- 2010/05/13 00:00 [received]
PHST- 2011/01/25 00:00 [accepted]
PHST- 2011/01/27 06:00 [entrez]
PHST- 2011/01/27 06:00 [pubmed]
PHST- 2011/04/13 06:00 [medline]
AID - 1472-6939-12-2 [pii]
AID - 10.1186/1472-6939-12-2 [doi]
PST - epublish
SO  - BMC Med Ethics. 2011 Jan 25;12:2. doi: 10.1186/1472-6939-12-2.


PMID- 21266001
OWN - NLM
STAT- MEDLINE
DCOM- 20111006
LR  - 20110727
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 11
IP  - 2
DP  - 2011 Aug
TI  - The adequacy of informed consent forms in genetic research in Oman: a pilot
      study.
PG  - 57-62
LID - 10.1111/j.1471-8847.2010.00293.x [doi]
AB  - Genetic research presents ethical challenges to the achievement of valid informed
      consent, especially in developing countries with areas of low literacy. During
      the last several years, a number of genetic research proposals involving Omani
      nationals were submitted to the Department of Research and Studies, Ministry of
      Health, Oman. The objective of this paper is to report on the results of an
      internal quality assurance initiative to determine the extent of the information 
      being provided in genetic research informed consent forms. In order to achieve
      this, we developed checklists to assess the inclusion of basic elements of
      informed consent as well as elements related to the collection and future storage
      of biological samples. Three of the authors independently evaluated and reached
      consensus on seven informed consent forms that were available for review. Of the 
      seven consent forms, four had less than half of the basic elements of informed
      consent. None contained any information regarding whether genetic information
      relevant to health would be disclosed, whether participants may share in
      commercial products, the extent of confidentiality protections, and the inclusion
      of additional consent forms for future storage and use of tissue samples.
      Information regarding genetic risks and withdrawal of samples were rarely
      mentioned (1/7), whereas limits on future use of samples were mentioned in 3 of 7
      consent forms. Ultimately, consent forms are not likely to address key issues
      regarding genetic research that have been recommended by research ethics
      guidelines. We recommend enhanced educational efforts to increase awareness, on
      the part of researchers, of information that should be included in consent forms.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Al-Riyami, Asya
AU  - Al-Riyami A
AD  - Ministry of Health, Oman and Research and Ethics Committee, Sultanate of Oman.
      asyariyami@gmail.com
FAU - Jaju, Deepali
AU  - Jaju D
FAU - Jaju, Sanjay
AU  - Jaju S
FAU - Silverman, Henry J
AU  - Silverman HJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110125
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
SB  - IM
MH  - *Confidentiality/ethics/standards
MH  - Consent Forms/ethics/*standards
MH  - Educational Status
MH  - Ethics, Research
MH  - Genetic Research/*ethics
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Oman
MH  - Pilot Projects
MH  - *Quality Assurance, Health Care
MH  - *Truth Disclosure/ethics
EDAT- 2011/01/27 06:00
MHDA- 2011/10/07 06:00
CRDT- 2011/01/27 06:00
PHST- 2011/01/27 06:00 [entrez]
PHST- 2011/01/27 06:00 [pubmed]
PHST- 2011/10/07 06:00 [medline]
AID - 10.1111/j.1471-8847.2010.00293.x [doi]
PST - ppublish
SO  - Dev World Bioeth. 2011 Aug;11(2):57-62. doi: 10.1111/j.1471-8847.2010.00293.x.
      Epub 2011 Jan 25.


PMID- 21265969
OWN - NLM
STAT- MEDLINE
DCOM- 20110607
LR  - 20110901
IS  - 1445-5994 (Electronic)
IS  - 1444-0903 (Linking)
VI  - 41
IP  - 1a
DP  - 2011 Jan
TI  - 2007 National Statement on Ethical Conduct in Human Research: not worth the paper
      it is written on?
PG  - 73
LID - 10.1111/j.1445-5994.2010.02420.x [doi]
FAU - Smith, M
AU  - Smith M
AD  - Repatriation General Hospital, Adelaide, South Australia, Australia.
LA  - eng
PT  - Letter
PL  - Australia
TA  - Intern Med J
JT  - Internal medicine journal
JID - 101092952
SB  - IM
CIN - Intern Med J. 2011 Jul;41(7):581-2. PMID: 21762341
MH  - Australia
MH  - *Ethics Committees, Research
MH  - Guideline Adherence
MH  - *Guidelines as Topic
MH  - Human Experimentation/*ethics/standards
MH  - Humans
EDAT- 2011/01/27 06:00
MHDA- 2011/06/08 06:00
CRDT- 2011/01/27 06:00
PHST- 2011/01/27 06:00 [entrez]
PHST- 2011/01/27 06:00 [pubmed]
PHST- 2011/06/08 06:00 [medline]
AID - 10.1111/j.1445-5994.2010.02420.x [doi]
PST - ppublish
SO  - Intern Med J. 2011 Jan;41(1a):73. doi: 10.1111/j.1445-5994.2010.02420.x.


PMID- 21265934
OWN - NLM
STAT- MEDLINE
DCOM- 20110506
LR  - 20110126
IS  - 1440-1819 (Electronic)
IS  - 1323-1316 (Linking)
VI  - 65
IP  - 1
DP  - 2011 Feb
TI  - Pharmacogenomics of antipsychotics efficacy for schizophrenia.
PG  - 3-19
LID - 10.1111/j.1440-1819.2010.02168.x [doi]
AB  - Central nervous system disorders are the third greatest health problem in
      developed countries, and schizophrenia represents some of the most disabling
      ailments in young individuals. There is an abuse and/or misuse of antipsychotics,
      and recent advances in pharmacogenomics pose new challenges for the clinical
      management of this complex disorder. Schizophrenia is a multi-factorial/polygenic
      complex disorder in which hundreds of different genes are potentially involved,
      leading to the phenotypic expression of the disease in conjunction with
      epigenetic and environmental phenomena. Consequently, structural and functional
      genomic changes induce proteomic and metabolomic defects associated with the
      disease phenotype. Disease-related genomic profiles and genetic variants in genes
      involved in drug metabolism are responsible for drug efficacy and safety. About
      20% of Caucasians are defective in CYP2D6 enzymes, which participate in the
      metabolism of 25-30% of central nervous system drugs. Approximately 40% of
      antipsychotics are substrates of CYP2D6 enzymes, 23% are substrates of CYP3A4,
      and 18% are substrates of CYP1A2. In order to achieve a mature discipline of
      pharmacogenomics of schizophrenia it would be effective to accelerate: (i) the
      education of physicians and the public in the use of genomic screening in daily
      clinical practice; (ii) the standardization of genetic testing for major
      categories of drugs; (iii) the validation of pharmacogenomic procedures according
      to drug category and pathology; (iv) the regulation of ethical, social, and
      economic issues; and (v) the incorporation of pharmacogenomic procedures of drugs
      in development and drugs on the market in order to optimize therapeutics.
CI  - (c) 2011 The Authors. Psychiatry and Clinical Neurosciences (c) 2011 Japanese
      Society of Psychiatry and Neurology.
FAU - Cacabelos, Ramon
AU  - Cacabelos R
AD  - EuroEspes Biomedical Research Center, Institute for CNS Disorders and Genomic
      Medicine, Bergondo, Coruna, Spain.
FAU - Hashimoto, Ryota
AU  - Hashimoto R
FAU - Takeda, Masatoshi
AU  - Takeda M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Australia
TA  - Psychiatry Clin Neurosci
JT  - Psychiatry and clinical neurosciences
JID - 9513551
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Receptors, Dopamine)
RN  - 0 (Receptors, Serotonin)
RN  - 9035-51-2 (Cytochrome P-450 Enzyme System)
SB  - IM
MH  - Antipsychotic Agents/pharmacokinetics/pharmacology/*therapeutic use
MH  - Cytochrome P-450 Enzyme System/genetics
MH  - Genes/genetics
MH  - Genome-Wide Association Study
MH  - Humans
MH  - *Pharmacogenetics
MH  - Receptors, Dopamine/drug effects/genetics
MH  - Receptors, Serotonin/drug effects/genetics
MH  - Schizophrenia/*drug therapy/genetics
EDAT- 2011/01/27 06:00
MHDA- 2011/05/07 06:00
CRDT- 2011/01/27 06:00
PHST- 2011/01/27 06:00 [entrez]
PHST- 2011/01/27 06:00 [pubmed]
PHST- 2011/05/07 06:00 [medline]
AID - 10.1111/j.1440-1819.2010.02168.x [doi]
PST - ppublish
SO  - Psychiatry Clin Neurosci. 2011 Feb;65(1):3-19. doi:
      10.1111/j.1440-1819.2010.02168.x.


PMID- 21265842
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20201209
IS  - 1556-4029 (Electronic)
IS  - 0022-1198 (Linking)
VI  - 56
IP  - 2
DP  - 2011 Mar
TI  - Ethical and legal consideration of prisoner's hunger strike in Serbia.
PG  - 547-50
LID - 10.1111/j.1556-4029.2010.01669.x [doi]
AB  - Hunger strike of prisoners and detainees remains a major human rights and ethical
      issue for medical professionals. We are reporting on a case of a 48-year-old male
      sentenced prisoner, intravenous heroin user, who went on a hunger strike and died
      15 days later. Throughout the fasting period, the prisoner, who was capable of
      decision making, refused any medical examination. Autopsy findings were not
      supporting prolonged starvation, while toxicology revealed benzodiazepines and
      opiates in blood and urine. Cause of death was given as "heroin intoxication" in 
      keeping with detection of 6-MAM. Legal and ethical issues pertinent to medical
      examination and treatment of prisoners on hunger strike are explored in
      accordance with legislation and professional ethical standards in Serbia. A
      recommendation for the best autopsy practice in deaths following hunger strike
      has been made.
CI  - (c) 2011 American Academy of Forensic Sciences.
FAU - Alempijevic, Djordje
AU  - Alempijevic D
AD  - Institute of Forensic Medicine, Faculty of Medicine, University of Belgrade, 31a 
      Deligradska Street, Belgrade 11000, Serbia. djolea@fon.rs
FAU - Pavlekic, Snezana
AU  - Pavlekic S
FAU - Jecmenica, Dragan
AU  - Jecmenica D
FAU - Nedeljkov, Aleksandra
AU  - Nedeljkov A
FAU - Jankovic, Milos
AU  - Jankovic M
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20110125
PL  - United States
TA  - J Forensic Sci
JT  - Journal of forensic sciences
JID - 0375370
RN  - 0 (Morphine Derivatives)
RN  - 0 (Narcotics)
RN  - 33CM23913M (Carbamazepine)
RN  - 70D95007SX (Heroin)
RN  - 76I7G6D29C (Morphine)
RN  - M5E47P1ZCH (6-O-monoacetylmorphine)
RN  - UX6OWY2V7J (Codeine)
SB  - IM
MH  - Carbamazepine/blood/urine
MH  - Codeine/blood/urine
MH  - Dissent and Disputes/*legislation & jurisprudence
MH  - *Fasting
MH  - Forensic Toxicology
MH  - Heroin/*poisoning
MH  - Heroin Dependence/complications
MH  - Humans
MH  - Liver Cirrhosis/pathology
MH  - Male
MH  - Middle Aged
MH  - Morphine/blood/urine
MH  - Morphine Derivatives/blood
MH  - Narcotics/blood/*poisoning/urine
MH  - *Prisoners
MH  - Serbia
EDAT- 2011/01/27 06:00
MHDA- 2011/06/29 06:00
CRDT- 2011/01/27 06:00
PHST- 2011/01/27 06:00 [entrez]
PHST- 2011/01/27 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
AID - 10.1111/j.1556-4029.2010.01669.x [doi]
PST - ppublish
SO  - J Forensic Sci. 2011 Mar;56(2):547-50. doi: 10.1111/j.1556-4029.2010.01669.x.
      Epub 2011 Jan 25.


PMID- 21265623
OWN - NLM
STAT- MEDLINE
DCOM- 20110601
LR  - 20110404
IS  - 1938-5404 (Electronic)
IS  - 0033-7587 (Linking)
VI  - 175
IP  - 4
DP  - 2011 Apr
TI  - The European radiobiological archives: online access to data from radiobiological
      experiments.
PG  - 526-31
LID - 10.1667/RR2471.1 [doi]
AB  - For financial and ethical reasons, the large-scale radiobiological animal studies
      conducted over the past 50 years are, to a large extent, unrepeatable
      experiments. It is therefore important to retain the primary data from these
      experiments to allow reanalysis, reinterpretation and re-evaluation of results
      from, for example, carcinogenicity studies, in the light of new knowledge in
      radiation biology. Consequently, there is an imperative need to keep these data
      available for the research community. The European Radiobiological Archives (ERA)
      were developed to fulfill this task. ERA has become a unique archive, including
      information from almost all European long-term studies carried out between the
      1960s and the 1990s. The legacy database was originally developed in a manner
      that precluded online use. Therefore, strong efforts were made to transform it
      into a version that is available online through the web. This went together with 
      quality assurance measures, including first the estimation of the rate of
      non-systematic errors in data entry, which at 2% proved to be very low. Second,
      every data set was compared against two external sources of information.
      Standardization of terminology and histopathology is a prerequisite for
      meaningful comparison of data across studies and analysis of potential
      carcinogenic effects. Standardization is particularly critical for the
      construction of a database that includes data from different studies evaluated by
      pathologists in different laboratories. A harmonized pathology nomenclature with 
      modern standard pathology terms was introduced. As far as possible, references
      for the various studies were directly linked to the studies themselves. Further, 
      a direct link to the JANUS database was established. ERA is now in a position
      where it has the potential to become a worldwide radiobiological research tool.
      ERA can be accessed at no cost at https://era.bfs.de. An ID and password can be
      obtained from the curators at era@bfs.de .
CI  - (c) 2011 by Radiation Research Society
FAU - Birschwilks, M
AU  - Birschwilks M
AD  - Federal Office for Radiation Protection, Department of Radiation Protection and
      Health, 85764 Neuherberg, Germany. mbirschwilks@bfs.de
FAU - Gruenberger, M
AU  - Gruenberger M
FAU - Adelmann, C
AU  - Adelmann C
FAU - Tapio, S
AU  - Tapio S
FAU - Gerber, G
AU  - Gerber G
FAU - Schofield, P N
AU  - Schofield PN
FAU - Grosche, B
AU  - Grosche B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110125
PL  - United States
TA  - Radiat Res
JT  - Radiation research
JID - 0401245
SB  - IM
MH  - *Archives
MH  - Data Mining/*methods
MH  - *Databases, Factual
MH  - Europe
MH  - Information Dissemination/*methods
MH  - *Internet
MH  - Online Systems
MH  - *Radiobiology
MH  - *Research Design
MH  - User-Computer Interface
EDAT- 2011/01/27 06:00
MHDA- 2011/06/02 06:00
CRDT- 2011/01/27 06:00
PHST- 2011/01/27 06:00 [entrez]
PHST- 2011/01/27 06:00 [pubmed]
PHST- 2011/06/02 06:00 [medline]
AID - 10.1667/RR2471.1 [pii]
AID - 10.1667/RR2471.1 [doi]
PST - ppublish
SO  - Radiat Res. 2011 Apr;175(4):526-31. doi: 10.1667/RR2471.1. Epub 2011 Jan 25.


PMID- 21265039
OWN - NLM
STAT- MEDLINE
DCOM- 20110429
LR  - 20110125
IS  - 1935-9780 (Electronic)
IS  - 1935-9772 (Linking)
VI  - 4
IP  - 1
DP  - 2011 Jan-Feb
TI  - Ethical care and use of cadavers: a call for a policy.
PG  - 53-4
LID - 10.1002/ase.201 [doi]
FAU - Bernanke, David H
AU  - Bernanke DH
LA  - eng
PT  - Comment
PT  - Letter
DEP - 20110117
PL  - United States
TA  - Anat Sci Educ
JT  - Anatomical sciences education
JID - 101392205
SB  - IM
CON - Anat Sci Educ. 2011 Jan-Feb;4(1):49-52. PMID: 21265038
MH  - *Cadaver
MH  - *Ethics
MH  - Humans
MH  - *Policy
EDAT- 2011/01/26 06:00
MHDA- 2011/04/30 06:00
CRDT- 2011/01/26 06:00
PHST- 2010/12/13 00:00 [received]
PHST- 2010/12/14 00:00 [accepted]
PHST- 2011/01/26 06:00 [entrez]
PHST- 2011/01/26 06:00 [pubmed]
PHST- 2011/04/30 06:00 [medline]
AID - 10.1002/ase.201 [doi]
PST - ppublish
SO  - Anat Sci Educ. 2011 Jan-Feb;4(1):53-4. doi: 10.1002/ase.201. Epub 2011 Jan 17.


PMID- 21265038
OWN - NLM
STAT- MEDLINE
DCOM- 20110429
LR  - 20110706
IS  - 1935-9780 (Electronic)
IS  - 1935-9772 (Linking)
VI  - 4
IP  - 1
DP  - 2011 Jan-Feb
TI  - A proposal for a policy on the ethical care and use of cadavers and their
      tissues.
PG  - 49-52
LID - 10.1002/ase.199 [doi]
AB  - Recent events have occurred that indicate the need for policies on the ethical
      care and use of cadavers and their tissues in the United States. At present,
      there are policies that address the procurement, handling and disposition of
      cadavers, but there are no national or society sponsored policies that clearly
      state the ethically appropriate use of cadavers. The ethical issues presented in 
      this manuscript are meant to encourage thought and discussion on this topic. A
      proposed outcome would be the development of specific ethical guidelines that
      would be sponsored by national organizations, such as the American Association of
      Anatomists and/or the American Association of Clinical Anatomists, and would be
      adopted by institutions that use cadavers or their tissues.
CI  - Copyright (c) 2011 American Association of Anatomists.
FAU - Champney, Thomas H
AU  - Champney TH
AD  - Department of Cell Biology and Anatomy, Miller School of Medicine, University of 
      Miami, 1600 NW 10th Avenue, Miami, Fl 33136, USA. tchampney@med.miami.edu
LA  - eng
PT  - Journal Article
DEP - 20110117
PL  - United States
TA  - Anat Sci Educ
JT  - Anatomical sciences education
JID - 101392205
SB  - IM
CIN - Anat Sci Educ. 2011 Jan-Feb;4(1):55. PMID: 21259448
CIN - Anat Sci Educ. 2011 Jan-Feb;4(1):53-4. PMID: 21265039
CIN - Anat Sci Educ. 2011 May-Jun;4(3):178-9. PMID: 21523918
MH  - Animals
MH  - *Cadaver
MH  - *Ethics
MH  - Humans
MH  - *Policy
EDAT- 2011/01/26 06:00
MHDA- 2011/04/30 06:00
CRDT- 2011/01/26 06:00
PHST- 2010/10/20 00:00 [received]
PHST- 2010/12/10 00:00 [accepted]
PHST- 2011/01/26 06:00 [entrez]
PHST- 2011/01/26 06:00 [pubmed]
PHST- 2011/04/30 06:00 [medline]
AID - 10.1002/ase.199 [doi]
PST - ppublish
SO  - Anat Sci Educ. 2011 Jan-Feb;4(1):49-52. doi: 10.1002/ase.199. Epub 2011 Jan 17.


PMID- 21265035
OWN - NLM
STAT- MEDLINE
DCOM- 20110429
LR  - 20211203
IS  - 1935-9780 (Electronic)
IS  - 1935-9772 (Linking)
VI  - 4
IP  - 1
DP  - 2011 Jan-Feb
TI  - The trend of body donation for education based on Korean social and religious
      culture.
PG  - 33-8
LID - 10.1002/ase.198 [doi]
AB  - Until a century ago, Korean medicine was based mainly on Oriental philosophies
      and ideas. From a religious perspective, Chinese Confucianism was prevalent in
      Korea at that time. Since Confucianists believe that it is against one's filial
      duty to harm his or her body, given to them by their parents, most Koreans did
      not donate their bodies or organs for education in the past. However, by the end 
      of the 20th century, a unique fusion of Western and Oriental medicines were
      produced on the Korean Peninsula, revolutionizing traditional perspectives on the
      human body, mortality, and the relationship of medical science to society.
      Koreans began to think about others' lives as well as their own by realizing the 
      importance of donating one's organs and bodies for scientific purposes. Since
      then, the number of people donating their bodies to Korean medical and dental
      schools for the purpose of improving academic learning has increased
      dramatically. In response, Korean medical schools have begun to hold various
      types of funeral ceremonies to honor body donors. We have compared such
      ceremonies performed in Korea with those performed in the United States of
      America and Taiwan. These ceremonies are viewed as a suitable way to pay proper
      respect to the dead and to promote knowledge about body donation programs in
      Korea. Overall, the transition of religions and social ethics in Korea has
      greatly facilitated body bequeathal programs, benefiting both medical education
      and the Korean public health administration.
CI  - Copyright (c) 2011 American Association of Anatomists.
FAU - Park, Jong-Tae
AU  - Park JT
AD  - Department of Oral Biology, Division in Anatomy and Developmental Biology, Human 
      Identification Research Center, Brain Korea 21 Project, Yonsei University College
      of Dentistry, Seoul, South Korea.
FAU - Jang, Yoonsun
AU  - Jang Y
FAU - Park, Min Sun
AU  - Park MS
FAU - Pae, Calvin
AU  - Pae C
FAU - Park, Jinyi
AU  - Park J
FAU - Hu, Kyung-Seok
AU  - Hu KS
FAU - Park, Jin-Seo
AU  - Park JS
FAU - Han, Seung-Ho
AU  - Han SH
FAU - Koh, Ki-Seok
AU  - Koh KS
FAU - Kim, Hee-Jin
AU  - Kim HJ
LA  - eng
PT  - Journal Article
DEP - 20110111
PL  - United States
TA  - Anat Sci Educ
JT  - Anatomical sciences education
JID - 101392205
SB  - IM
MH  - Asians/psychology
MH  - *Cadaver
MH  - Education, Medical/*trends
MH  - *Funeral Rites
MH  - Humans
MH  - Republic of Korea
MH  - *Tissue Donors
MH  - Tissue and Organ Procurement/*trends
EDAT- 2011/01/26 06:00
MHDA- 2011/04/30 06:00
CRDT- 2011/01/26 06:00
PHST- 2010/09/02 00:00 [received]
PHST- 2010/11/09 00:00 [revised]
PHST- 2010/12/13 00:00 [accepted]
PHST- 2011/01/26 06:00 [entrez]
PHST- 2011/01/26 06:00 [pubmed]
PHST- 2011/04/30 06:00 [medline]
AID - 10.1002/ase.198 [doi]
PST - ppublish
SO  - Anat Sci Educ. 2011 Jan-Feb;4(1):33-8. doi: 10.1002/ase.198. Epub 2011 Jan 11.


PMID- 21264774
OWN - NLM
STAT- MEDLINE
DCOM- 20110520
LR  - 20211020
IS  - 1436-2813 (Electronic)
IS  - 0941-1291 (Linking)
VI  - 41
IP  - 2
DP  - 2011 Feb
TI  - Hemostasis of the liver, spleen, and bone achieved by electrocautery greased with
      lidocaine gel.
PG  - 300-2
LID - 10.1007/s00595-009-4211-6 [doi]
AB  - Despite advances in surgical techniques, achieving hemostasis of the liver,
      spleen, and bone during major surgery, especially after trauma, is still
      difficult. I describe a new procedure my colleagues and I devised to achieve
      parenchymatous hemostasis using electrocautery greased with lidocaine gel. After 
      achieving good results in experimental studies and obtaining approval from our
      ethics committee, we used electrocautery greased with lidocaine gel for
      hemostasis in the following 36 procedures: multisegmental hepatectomy to remove
      hepatic tumors (n = 6); partial hepatectomy to allow hepatojejunostomy for
      intrahepatic biliary obstruction (n = 10); laparoscopic liver biopsy (n = 4);
      subtotal splenectomy (n = 8; for portal hypertension in 5 patients, splenic
      ischemia in 2, and Gaucher's disease in 1); laparoscopic splenic biopsy (n = 1); 
      and bone resection (n = 7; as pelvic-femoral resection in 6 patients and to
      remove a rectal tumor invading the coccyx in 1). This procedure was easy to
      perform and achieved complete hemostasis of the minor blood vessels in all
      patients. No postoperative bleeding occurred and the follow-up course was
      satisfactory. Electrocautery greased with lidocaine gel is an inexpensive,
      readily available, and efficient method to achieve hemostasis of minor vessels in
      hepatic, splenic, and bone operations.
FAU - Petroianu, Andy
AU  - Petroianu A
AD  - Department of Surgery of the Medical School, Federal University of Minas Gerais, 
      Belo Horizonte, MG, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20110126
PL  - Japan
TA  - Surg Today
JT  - Surgery today
JID - 9204360
RN  - 0 (Gels)
RN  - 98PI200987 (Lidocaine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Bone and Bones/*surgery
MH  - Electrocoagulation/*methods
MH  - Female
MH  - Gels
MH  - *Hemostatic Techniques
MH  - Humans
MH  - Lidocaine/*administration & dosage
MH  - Liver/*surgery
MH  - Male
MH  - Middle Aged
MH  - Spleen/*surgery
EDAT- 2011/01/26 06:00
MHDA- 2011/05/21 06:00
CRDT- 2011/01/26 06:00
PHST- 2009/07/01 00:00 [received]
PHST- 2009/09/04 00:00 [accepted]
PHST- 2011/01/26 06:00 [entrez]
PHST- 2011/01/26 06:00 [pubmed]
PHST- 2011/05/21 06:00 [medline]
AID - 10.1007/s00595-009-4211-6 [doi]
PST - ppublish
SO  - Surg Today. 2011 Feb;41(2):300-2. doi: 10.1007/s00595-009-4211-6. Epub 2011 Jan
      26.


PMID- 21264669
OWN - NLM
STAT- MEDLINE
DCOM- 20110801
LR  - 20220311
IS  - 1432-1238 (Electronic)
IS  - 0342-4642 (Linking)
VI  - 37
IP  - 4
DP  - 2011 Apr
TI  - Attitudes towards ethical problems in critical care medicine: the Chinese
      perspective.
PG  - 655-64
LID - 10.1007/s00134-010-2124-x [doi]
AB  - INTRODUCTION: Critical care doctors are frequently faced with clinical problems
      that have important ethical and moral dimensions. While Western attitudes and
      practice are well documented, little is known of the attitudes or practice of
      Chinese critical care doctors. METHODS: An anonymous, written, structured
      questionnaire survey was translated from previously reported ethical surveys used
      in Europe and Hong Kong. A snowball method was used to identify 534 potential
      participants from 21 regions in China. RESULTS: A total of 315 (59%) valid
      responses were analysed. Most respondents (66%) reported that admission to an
      intensive care unit (ICU) was commonly limited by bed availability, but most
      (63%) would admit patients with a poor prognosis to ICU. Only 19% of respondents 
      gave complete information to patients and family, with most providing
      individually adjusted information, based on prognosis and the recipient's
      educational level. Only 28% disclosed all details of an iatrogenic incident,
      despite 62% stating that they should. The use of do not resuscitate orders or
      limitation of life-sustaining therapy in terminally ill patients reported as
      uncommon and according to comparable reports, both are more common practice in
      Hong Kong or Europe. In contrast to European practices, doctors were more
      acquiescent to families in decision-making at the end of life. CONCLUSIONS: A
      number of differences in ethical attitudes and related behaviour between Chinese,
      Hong Kong and European ICU doctors were documented. A likely explanation is
      differing cultural background, and doctors should be aware of likely expectations
      when treating patients from a different culture.
FAU - Weng, Li
AU  - Weng L
AD  - Medical Intensive Care Unit, Peking Union Medical College Hospital, Peking Union 
      Medical College and Chinese Academy of Medical Sciences, Beijing, 100730,
      People's Republic of China.
FAU - Joynt, Gavin M
AU  - Joynt GM
FAU - Lee, Anna
AU  - Lee A
FAU - Du, Bin
AU  - Du B
FAU - Leung, Patricia
AU  - Leung P
FAU - Peng, Jinming
AU  - Peng J
FAU - Gomersall, Charles D
AU  - Gomersall CD
FAU - Hu, Xiaoyun
AU  - Hu X
FAU - Yap, Hui Y
AU  - Yap HY
CN  - Chinese Critical Care Ethics Group
LA  - eng
PT  - Journal Article
DEP - 20110125
PL  - United States
TA  - Intensive Care Med
JT  - Intensive care medicine
JID - 7704851
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - China
MH  - Critical Care/*ethics
MH  - Female
MH  - Humans
MH  - Intensive Care Units/statistics & numerical data
MH  - Male
MH  - Middle Aged
MH  - Surveys and Questionnaires
MH  - Terminal Care/ethics
MH  - Triage
IR  - Liang FJ
FIR - Liang, F J
IR  - Mao RZ
FIR - Mao, R Z
IR  - Wang XW
FIR - Wang, X W
IR  - Bu L
FIR - Bu, L
IR  - Xu YH
FIR - Xu, Y H
IR  - Cao W
FIR - Cao, W
IR  - Liu FY
FIR - Liu, F Y
IR  - Zhu FX
FIR - Zhu, F X
IR  - Fu HJ
FIR - Fu, H J
IR  - Ning B
FIR - Ning, B
IR  - Xie YC
FIR - Xie, Y C
IR  - Zhou Y
FIR - Zhou, Y
IR  - Qi JY
FIR - Qi, J Y
IR  - Zhang R
FIR - Zhang, R
EDAT- 2011/01/26 06:00
MHDA- 2011/08/02 06:00
CRDT- 2011/01/26 06:00
PHST- 2010/03/25 00:00 [received]
PHST- 2010/11/16 00:00 [accepted]
PHST- 2011/01/26 06:00 [entrez]
PHST- 2011/01/26 06:00 [pubmed]
PHST- 2011/08/02 06:00 [medline]
AID - 10.1007/s00134-010-2124-x [doi]
PST - ppublish
SO  - Intensive Care Med. 2011 Apr;37(4):655-64. doi: 10.1007/s00134-010-2124-x. Epub
      2011 Jan 25.


PMID- 21264518
OWN - NLM
STAT- MEDLINE
DCOM- 20111027
LR  - 20211020
IS  - 1572-8633 (Electronic)
IS  - 1386-7423 (Linking)
VI  - 14
IP  - 3
DP  - 2011 Aug
TI  - Health and human rights: epistemological status and perspectives of development.
PG  - 237-47
LID - 10.1007/s11019-011-9310-7 [doi]
AB  - The health and human rights movement (HHR) shows obvious signs of maturation both
      internally and externally. Yet there are still many questions to be addressed.
      These issues include the movement's epistemological status and its perspectives
      of development. This paper discusses critically the conditions of emergence of
      HHR, its identity, its dominant schools of thought, its epistemological postures 
      and its methodological issues. Our analysis shows that: (a) the epistemological
      status of HHR is ambiguous; (b) its identity is uncertain in the absence of a
      validated definition: is it an action movement, an interdisciplinary field, a
      domain, an approach, a setting or a scientific discipline? (c) its main schools
      of thoughts are defined as "advocacists", "ethicists", "interventionists",
      "normativists"; (d) the movement is in the maturation process as a discipline in 
      which "interface", "distance", "interference" and "fusion" epistemological
      postures represent the fundamental steps; (e) parent disciplines (health sciences
      and law) competences, logics and cultures introduce duality and difficulties in
      knowledge production, validation and diffusion; (f) there is need to re-write the
      history of the HHR movement by inscribing it not only into the humanitarian or
      public health perspectives but also into the evolution of sciences and its
      social, political and economical conditions of emergence. The ambiguous
      epistemological status of this field, the need to re-write its history, the
      methodological duality in its research, the question of the competence of the
      knowledge validation, as well as the impact of HHR practice on national and
      international health governance are the challenges of its future development. To 
      meet those challenges; we call for the creation and implementation of an
      international research agenda, the exploration of new research topics and the
      evaluation of the movement's contribution to the national and global public
      health and human rights governance.
FAU - Mpinga, Emmanuel Kabengele
AU  - Mpinga EK
AD  - Institute of Social and Preventive Medicine, Centre Medical Universitaire,
      Faculty of Medicine, Geneva University, Switzerland. Emmanuel.Kabengele@unige.ch
FAU - London, Leslie
AU  - London L
FAU - Chastonay, Philippe
AU  - Chastonay P
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Med Health Care Philos
JT  - Medicine, health care, and philosophy
JID - 9815900
SB  - IM
MH  - Ethics
MH  - Global Health
MH  - Health Policy
MH  - *Human Rights
MH  - Humans
MH  - Knowledge
MH  - *Philosophy, Medical
MH  - Public Health/ethics
MH  - Research/*organization & administration
MH  - Sociology, Medical
EDAT- 2011/01/26 06:00
MHDA- 2011/10/28 06:00
CRDT- 2011/01/26 06:00
PHST- 2011/01/26 06:00 [entrez]
PHST- 2011/01/26 06:00 [pubmed]
PHST- 2011/10/28 06:00 [medline]
AID - 10.1007/s11019-011-9310-7 [doi]
PST - ppublish
SO  - Med Health Care Philos. 2011 Aug;14(3):237-47. doi: 10.1007/s11019-011-9310-7.


PMID- 21264501
OWN - NLM
STAT- MEDLINE
DCOM- 20110823
LR  - 20211020
IS  - 1573-3599 (Electronic)
IS  - 1059-7700 (Linking)
VI  - 20
IP  - 3
DP  - 2011 Jun
TI  - Ethical dilemmas in genetic testing: examples from the Cuban program for
      predictive diagnosis of hereditary ataxias.
PG  - 241-8
LID - 10.1007/s10897-010-9347-4 [doi]
AB  - Predictive testing protocols are intended to help patients affected with
      hereditary conditions understand their condition and make informed reproductive
      choices. However, predictive protocols may expose clinicians and patients to
      ethical dilemmas that interfere with genetic counseling and the decision making
      process. This paper describes ethical dilemmas in a series of five cases
      involving predictive testing for hereditary ataxias in Cuba. The examples herein 
      present evidence of the deeply controversial situations faced by both individuals
      at risk and professionals in charge of these predictive studies, suggesting a
      need for expanded guidelines to address such complexities.
FAU - Marino, Tania Cruz
AU  - Marino TC
AD  - Predictive Genetics Department, Center for Research and Rehabilitation of
      Hereditary Ataxias (CIRAH), Holguin, Cuba. taniacmarin@infomed.sld.cu
FAU - Arminan, Ruben Reynaldo
AU  - Arminan RR
FAU - Cedeno, Humberto Jorge
AU  - Cedeno HJ
FAU - Mesa, Jose Miguel Laffita
AU  - Mesa JM
FAU - Zaldivar, Yanetza Gonzalez
AU  - Zaldivar YG
FAU - Rodriguez, Raul Aguilera
AU  - Rodriguez RA
FAU - Santos, Miguel Velazquez
AU  - Santos MV
FAU - Mederos, Luis Enrique Almaguer
AU  - Mederos LE
FAU - Herrera, Milena Paneque
AU  - Herrera MP
FAU - Perez, Luis Velazquez
AU  - Perez LV
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20110125
PL  - United States
TA  - J Genet Couns
JT  - Journal of genetic counseling
JID - 9206865
RN  - 0 (Ataxins)
RN  - 0 (Nerve Tissue Proteins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Ataxins
MH  - Cuba
MH  - *Ethics, Medical
MH  - Female
MH  - Genetic Carrier Screening
MH  - Genetic Testing/*ethics
MH  - Humans
MH  - Nerve Tissue Proteins/genetics
MH  - Pedigree
MH  - Predictive Value of Tests
MH  - Prenatal Diagnosis
MH  - Spinocerebellar Degenerations/*diagnosis/genetics
MH  - Twins, Monozygotic
EDAT- 2011/01/26 06:00
MHDA- 2011/08/24 06:00
CRDT- 2011/01/26 06:00
PHST- 2010/01/19 00:00 [received]
PHST- 2010/12/26 00:00 [accepted]
PHST- 2011/01/26 06:00 [entrez]
PHST- 2011/01/26 06:00 [pubmed]
PHST- 2011/08/24 06:00 [medline]
AID - 10.1007/s10897-010-9347-4 [doi]
PST - ppublish
SO  - J Genet Couns. 2011 Jun;20(3):241-8. doi: 10.1007/s10897-010-9347-4. Epub 2011
      Jan 25.


PMID- 21263066
OWN - NLM
STAT- MEDLINE
DCOM- 20110929
LR  - 20211020
IS  - 1465-3648 (Electronic)
IS  - 0268-1153 (Linking)
VI  - 26
IP  - 3
DP  - 2011 Jun
TI  - 'Who is Helsinki?' Sex workers advise improving communication for good
      participatory practice in clinical trials.
PG  - 466-75
LID - 10.1093/her/cyq087 [doi]
AB  - After premature closures in 2004 of biomedical human immunodeficiency virus (HIV)
      prevention trials involving sex workers in Africa and Asia, the Joint United
      Nations Programme on HIV/AIDS (UNAIDS) and Global Advocacy for HIV Prevention
      (AVAC) undertook consultations to establish better participatory guidelines for
      such trials in order to address ethical concerns. This study investigated sex
      workers' knowledge and beliefs about research ethics and good participatory
      practices (GPP) and the perspectives of sex workers on research participation. A 
      33-question survey based on criteria identified by UNAIDS and AVAC was translated
      into three other languages. Participants were recruited through mailing lists and
      contacts with existing sex work networks. In total, 74 responses from Europe, the
      Americas and Asia were received. Thirty percent of respondents reported
      first-hand involvement in biomedical HIV prevention trials. Seventy percent
      indicated a lack of familiarity with codes of ethics for research. This paper
      focuses exclusively on communication issues described in survey responses.
      Communication was an important theme: the absence of clear communication between 
      trial participants and investigators contributed to premature trial closures in
      at least two sites. Sex workers had recommendations for how researchers might
      implement GPP through improved communication, including consultation at the
      outset of planning, explaining procedures in non-technical terms and establishing
      clear channels for feedback from participants.
FAU - Ditmore, Melissa Hope
AU  - Ditmore MH
AD  - New York, NY 10009, USA. mhd-her@taumail.com
FAU - Allman, Dan
AU  - Allman D
LA  - eng
GR  - T32 DA007233/DA/NIDA NIH HHS/United States
GR  - T32 DA07233/DA/NIDA NIH HHS/United States
GR  - CAPMC/ CIHR/Canada
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110124
PL  - England
TA  - Health Educ Res
JT  - Health education research
JID - 8608459
MH  - *Clinical Trials as Topic
MH  - *Communication
MH  - Data Collection
MH  - HIV Infections/prevention & control
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - *Sex Work
PMC - PMC3099186
EDAT- 2011/01/26 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/01/26 06:00
PHST- 2011/01/26 06:00 [entrez]
PHST- 2011/01/26 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - cyq087 [pii]
AID - 10.1093/her/cyq087 [doi]
PST - ppublish
SO  - Health Educ Res. 2011 Jun;26(3):466-75. doi: 10.1093/her/cyq087. Epub 2011 Jan
      24.


PMID- 21262087
OWN - NLM
STAT- MEDLINE
DCOM- 20110509
LR  - 20110125
IS  - 1471-6348 (Electronic)
IS  - 0266-4623 (Linking)
VI  - 27
IP  - 1
DP  - 2011 Jan
TI  - What aspects of the health technology assessment process recommended by
      international health technology assessment agencies received the most attention
      in Poland in 2008?
PG  - 84-94
LID - 10.1017/S0266462310001236 [doi]
AB  - OBJECTIVES: The primary objective of this study was to determine the extent to
      which international standards on transparency and quality are met by the health
      technology assessment (HTA) process in Poland. A secondary objective is to
      describe the outcomes of the HTA process and their associated factors. METHODS:
      All published online HTA appraisal and meeting proceedings on pharmaceutical
      products in 2008 were reviewed using a score card developed from international
      checklists recommended by INAHTA and ECHTA. RESULTS: The sixty-nine reports
      reviewed showed that five of nine transparency standards and six of eight quality
      standards were usually met by the HTA reports. Areas for improvement for
      transparency include inputs from external stakeholders, availability of English
      summaries, conclusions, implications of results, and suggested program of action.
      Areas of improvement for quality include appropriateness of target population and
      comparator/s, sufficiency of evidence on efficacy and safety, methodological
      rigor, economic model assumptions, and adaptation to the Polish setting. A
      consideration of the ethical and social consequences to the healthcare system
      must also be strengthened. CONCLUSIONS: The study demonstrates that the
      incorporation and implementation of the HTA appraisal process in Poland has been 
      successful. HTA appraisal reports in Poland have considered most of the
      international standards of transparency and quality. Recommendations for both HTA
      users and doers are forwarded for the improvement of the HTA process in the
      Polish setting.
FAU - Kolasa, Katarzyna
AU  - Kolasa K
AD  - Warsaw Medical University, Waszaw, Poland. kkolasa@wum.edu.pl
FAU - Dziomdziora, Malgorzata
AU  - Dziomdziora M
FAU - Fajutrao, Liberty
AU  - Fajutrao L
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Technol Assess Health Care
JT  - International journal of technology assessment in health care
JID - 8508113
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Disclosure/standards
MH  - *Internationality
MH  - Pharmaceutical Preparations
MH  - Poland
MH  - Research Report
MH  - Technology Assessment, Biomedical/*standards
EDAT- 2011/01/26 06:00
MHDA- 2011/05/10 06:00
CRDT- 2011/01/26 06:00
PHST- 2011/01/26 06:00 [entrez]
PHST- 2011/01/26 06:00 [pubmed]
PHST- 2011/05/10 06:00 [medline]
AID - S0266462310001236 [pii]
AID - 10.1017/S0266462310001236 [doi]
PST - ppublish
SO  - Int J Technol Assess Health Care. 2011 Jan;27(1):84-94. doi:
      10.1017/S0266462310001236.


PMID- 21262075
OWN - NLM
STAT- MEDLINE
DCOM- 20110509
LR  - 20110126
IS  - 1471-6348 (Electronic)
IS  - 0266-4623 (Linking)
VI  - 27
IP  - 1
DP  - 2011 Jan
TI  - Improving ethics analysis in health technology assessment.
PG  - 64-70
LID - 10.1017/S0266462310001303 [doi]
AB  - OBJECTIVES: The aim of this study was to critically examine the current guidance 
      for conducting ethics analysis in health technology assessment (HTA) and to offer
      recommendations for how to improve this practice. METHODS: MEDLINE, Philosopher's
      Index, and Google Scholar were searched for articles and reports using the
      keywords "ethics" and "health technology assessment" and related terms.
      Bibliographies of all relevant articles were also examined for additional
      references. A philosophical analysis of the existing guidance was conducted.
      RESULTS: We offer three recommendations for improving ethics analysis in HTA.
      First, ethical and legal issues must be clearly separated so that all
      policy-relevant questions that the technology raises can be considered clearly
      and systematically. Second, analysts must make better use of ethics theory and
      discuss better how particular theoretical approaches and associated analytic
      tools are selected to make transparent which alternative approaches were
      considered and why they were rejected. Third, the necessity for philosophical
      expertise to adequately conduct ethics analysis needs to be acknowledged.
      CONCLUSIONS: To act on these recommendations for ethics analysis, we offer these 
      three steps forward: acknowledge and use relevant expertise, further develop
      models for conducting and reporting ethics analyses, and make use of untapped
      resources in the literature.
FAU - Duthie, Katherine
AU  - Duthie K
AD  - University of Alberta, Royal Alexandra Hospital, Alberta, Canada.
      kduthie@ualberta.ca
FAU - Bond, Kenneth
AU  - Bond K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110125
PL  - England
TA  - Int J Technol Assess Health Care
JT  - International journal of technology assessment in health care
JID - 8508113
SB  - IM
MH  - Ethical Theory
MH  - Technology Assessment, Biomedical/*ethics
MH  - United States
EDAT- 2011/01/26 06:00
MHDA- 2011/05/10 06:00
CRDT- 2011/01/26 06:00
PHST- 2011/01/26 06:00 [entrez]
PHST- 2011/01/26 06:00 [pubmed]
PHST- 2011/05/10 06:00 [medline]
AID - S0266462310001303 [pii]
AID - 10.1017/S0266462310001303 [doi]
PST - ppublish
SO  - Int J Technol Assess Health Care. 2011 Jan;27(1):64-70. doi:
      10.1017/S0266462310001303. Epub 2011 Jan 25.


PMID- 21262067
OWN - NLM
STAT- MEDLINE
DCOM- 20110509
LR  - 20110126
IS  - 1471-6348 (Electronic)
IS  - 0266-4623 (Linking)
VI  - 27
IP  - 1
DP  - 2011 Jan
TI  - International survey on attitudes toward ethics in health technology assessment: 
      An exploratory study.
PG  - 50-4
LID - 10.1017/S0266462310001182 [doi]
AB  - OBJECTIVES: The objective of this exploratory study was to survey international
      health technology assessment (HTA) professionals to determine attitudes toward
      ethics in HTA. METHODS: An exploratory, quantitative, cross-sectional study
      design was developed. The sample population (n = 636) was selected from authors
      of the 206 articles published in the International Journal of Technology
      Assessment in Health Care between 2005 and 2007. A survey instrument was piloted 
      and e-mailed. RESULTS: The response rate was low (n = 104; 16.4 percent).
      Respondents were primarily middle-aged (46 +/- 11 years) male (62 percent) health
      professionals from Western countries (n = 92; 88.5 percent), with a mean of 10
      (+/- 6 years) years of HTA experience. Although at least 90 percent of
      respondents agreed that healthcare decisions involved value judgments and that
      ethical analysis was important to HTA, respondents were divided as to whether
      normative (n = 45; 44.6 percent) or descriptive (n = 38; 37.6 percent) ethical
      recommendations were necessary. Most respondents (n = 83; 81.4 percent) believed 
      that HTA should include citizen participation, but two thirds (n = 67; 67.0
      percent) agreed that the final decision should be restricted to decision makers. 
      A majority of respondents thought that ethical analysis could be discussed
      anywhere within the HTA process, either by an expert trained in ethics (n = 62;
      60.8 percent) or by an external consultant (n = 80; 78.4 percent). CONCLUSIONS:
      This study showed that ethical discourse in HTA is constrained by practical
      considerations, which serves to limit moral inquiry. To increase ethical
      analysis, a positive attitude toward ethics needs to be fostered within the HTA
      community.
FAU - Arellano, Luis E
AU  - Arellano LE
AD  - Katholieke Universiteit Leuven, Leuven, Belgium. luis.arellano@members.em-a.eu
FAU - Willett, Jeffrey M
AU  - Willett JM
FAU - Borry, Pascal
AU  - Borry P
LA  - eng
PT  - Journal Article
DEP - 20110125
PL  - England
TA  - Int J Technol Assess Health Care
JT  - International journal of technology assessment in health care
JID - 8508113
SB  - IM
MH  - Adult
MH  - *Attitude
MH  - Cross-Sectional Studies
MH  - Data Collection
MH  - Female
MH  - Humans
MH  - *Internationality
MH  - Male
MH  - Middle Aged
MH  - Technology Assessment, Biomedical/*ethics
EDAT- 2011/01/26 06:00
MHDA- 2011/05/10 06:00
CRDT- 2011/01/26 06:00
PHST- 2011/01/26 06:00 [entrez]
PHST- 2011/01/26 06:00 [pubmed]
PHST- 2011/05/10 06:00 [medline]
AID - S0266462310001182 [pii]
AID - 10.1017/S0266462310001182 [doi]
PST - ppublish
SO  - Int J Technol Assess Health Care. 2011 Jan;27(1):50-4. doi:
      10.1017/S0266462310001182. Epub 2011 Jan 25.


PMID- 21261939
OWN - NLM
STAT- MEDLINE
DCOM- 20110421
LR  - 20220408
IS  - 1475-2891 (Electronic)
IS  - 1475-2891 (Linking)
VI  - 10
DP  - 2011 Jan 24
TI  - Weight science: evaluating the evidence for a paradigm shift.
PG  - 9
LID - 10.1186/1475-2891-10-9 [doi]
AB  - Current guidelines recommend that "overweight" and "obese" individuals lose
      weight through engaging in lifestyle modification involving diet, exercise and
      other behavior change. This approach reliably induces short term weight loss, but
      the majority of individuals are unable to maintain weight loss over the long term
      and do not achieve the putative benefits of improved morbidity and mortality.
      Concern has arisen that this weight focus is not only ineffective at producing
      thinner, healthier bodies, but may also have unintended consequences,
      contributing to food and body preoccupation, repeated cycles of weight loss and
      regain, distraction from other personal health goals and wider health
      determinants, reduced self-esteem, eating disorders, other health decrement, and 
      weight stigmatization and discrimination. This concern has drawn increased
      attention to the ethical implications of recommending treatment that may be
      ineffective or damaging. A growing trans-disciplinary movement called Health at
      Every Size (HAES) challenges the value of promoting weight loss and dieting
      behavior and argues for a shift in focus to weight-neutral outcomes. Randomized
      controlled clinical trials indicate that a HAES approach is associated with
      statistically and clinically relevant improvements in physiological measures
      (e.g., blood pressure, blood lipids), health behaviors (e.g., eating and activity
      habits, dietary quality), and psychosocial outcomes (such as self-esteem and body
      image), and that HAES achieves these health outcomes more successfully than
      weight loss treatment and without the contraindications associated with a weight 
      focus. This paper evaluates the evidence and rationale that justifies shifting
      the health care paradigm from a conventional weight focus to HAES.
FAU - Bacon, Linda
AU  - Bacon L
AD  - University of California, Davis, USA. linda@lindabacon.org
FAU - Aphramor, Lucy
AU  - Aphramor L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110124
PL  - England
TA  - Nutr J
JT  - Nutrition journal
JID - 101152213
RN  - 0 (Lipids)
SB  - IM
EIN - Nutr J. 2011;10:69
MH  - *Adiposity
MH  - Blood Pressure
MH  - Body Image
MH  - Body Mass Index
MH  - *Body Weight
MH  - *Diet
MH  - Exercise
MH  - Feeding Behavior
MH  - Feeding and Eating Disorders
MH  - Health Behavior
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Lipids/blood
MH  - Obesity
MH  - Physical Fitness
MH  - Randomized Controlled Trials as Topic
MH  - Risk Factors
MH  - Self Concept
MH  - *Weight Loss
PMC - PMC3041737
EDAT- 2011/01/26 06:00
MHDA- 2011/04/22 06:00
CRDT- 2011/01/26 06:00
PHST- 2010/10/01 00:00 [received]
PHST- 2011/01/24 00:00 [accepted]
PHST- 2011/01/26 06:00 [entrez]
PHST- 2011/01/26 06:00 [pubmed]
PHST- 2011/04/22 06:00 [medline]
AID - 1475-2891-10-9 [pii]
AID - 10.1186/1475-2891-10-9 [doi]
PST - epublish
SO  - Nutr J. 2011 Jan 24;10:9. doi: 10.1186/1475-2891-10-9.


PMID- 21261657
OWN - NLM
STAT- MEDLINE
DCOM- 20110808
LR  - 20110407
IS  - 1398-9995 (Electronic)
IS  - 0105-4538 (Linking)
VI  - 66
IP  - 5
DP  - 2011 May
TI  - MeDALL (Mechanisms of the Development of ALLergy): an integrated approach from
      phenotypes to systems medicine.
PG  - 596-604
LID - 10.1111/j.1398-9995.2010.02534.x [doi]
AB  - The origin of the epidemic of IgE-associated (allergic) diseases is unclear.
      MeDALL (Mechanisms of the Development of ALLergy), an FP7 European Union project 
      (No. 264357), aims to generate novel knowledge on the mechanisms of initiation of
      allergy and to propose early diagnosis, prevention, and targets for therapy. A
      novel phenotype definition and an integrative translational approach are needed
      to understand how a network of molecular and environmental factors can lead to
      complex allergic diseases. A novel, stepwise, large-scale, and integrative
      approach will be led by a network of complementary experts in allergy,
      epidemiology, allergen biochemistry, immunology, molecular biology, epigenetics, 
      functional genomics, bioinformatics, computational and systems biology. The
      following steps are proposed: (i) Identification of 'classical' and 'novel'
      phenotypes in existing birth cohorts; (ii) Building discovery of the relevant
      mechanisms in IgE-associated allergic diseases in existing longitudinal birth
      cohorts and Karelian children; (iii) Validation and redefinition of classical and
      novel phenotypes of IgE-associated allergic diseases; and (iv) Translational
      integration of systems biology outcomes into health care, including societal
      aspects. MeDALL will lead to: (i) A better understanding of allergic phenotypes, 
      thus expanding current knowledge of the genomic and environmental determinants of
      allergic diseases in an integrative way; (ii) Novel diagnostic tools for the
      early diagnosis of allergy, targets for the development of novel treatment
      modalities, and prevention of allergic diseases; (iii) Improving the health of
      European citizens as well as increasing the competitiveness and boosting the
      innovative capacity of Europe, while addressing global health issues and ethical 
      issues.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Bousquet, J
AU  - Bousquet J
AD  - University Hospital, Department of Respiratory Diseases, Hopital Arnaud de
      Villeneuve, Montpellier, France. jean.bousquet@inserm.fr
FAU - Anto, J
AU  - Anto J
FAU - Auffray, C
AU  - Auffray C
FAU - Akdis, M
AU  - Akdis M
FAU - Cambon-Thomsen, A
AU  - Cambon-Thomsen A
FAU - Keil, T
AU  - Keil T
FAU - Haahtela, T
AU  - Haahtela T
FAU - Lambrecht, B N
AU  - Lambrecht BN
FAU - Postma, D S
AU  - Postma DS
FAU - Sunyer, J
AU  - Sunyer J
FAU - Valenta, R
AU  - Valenta R
FAU - Akdis, C A
AU  - Akdis CA
FAU - Annesi-Maesano, I
AU  - Annesi-Maesano I
FAU - Arno, A
AU  - Arno A
FAU - Bachert, C
AU  - Bachert C
FAU - Ballester, F
AU  - Ballester F
FAU - Basagana, X
AU  - Basagana X
FAU - Baumgartner, U
AU  - Baumgartner U
FAU - Bindslev-Jensen, C
AU  - Bindslev-Jensen C
FAU - Brunekreef, B
AU  - Brunekreef B
FAU - Carlsen, K H
AU  - Carlsen KH
FAU - Chatzi, L
AU  - Chatzi L
FAU - Crameri, R
AU  - Crameri R
FAU - Eveno, E
AU  - Eveno E
FAU - Forastiere, F
AU  - Forastiere F
FAU - Garcia-Aymerich, J
AU  - Garcia-Aymerich J
FAU - Guerra, S
AU  - Guerra S
FAU - Hammad, H
AU  - Hammad H
FAU - Heinrich, J
AU  - Heinrich J
FAU - Hirsch, D
AU  - Hirsch D
FAU - Jacquemin, B
AU  - Jacquemin B
FAU - Kauffmann, F
AU  - Kauffmann F
FAU - Kerkhof, M
AU  - Kerkhof M
FAU - Kogevinas, M
AU  - Kogevinas M
FAU - Koppelman, G H
AU  - Koppelman GH
FAU - Kowalski, M L
AU  - Kowalski ML
FAU - Lau, S
AU  - Lau S
FAU - Lodrup-Carlsen, K C
AU  - Lodrup-Carlsen KC
FAU - Lopez-Botet, M
AU  - Lopez-Botet M
FAU - Lotvall, J
AU  - Lotvall J
FAU - Lupinek, C
AU  - Lupinek C
FAU - Maier, D
AU  - Maier D
FAU - Makela, M J
AU  - Makela MJ
FAU - Martinez, F D
AU  - Martinez FD
FAU - Mestres, J
AU  - Mestres J
FAU - Momas, I
AU  - Momas I
FAU - Nawijn, M C
AU  - Nawijn MC
FAU - Neubauer, A
AU  - Neubauer A
FAU - Oddie, S
AU  - Oddie S
FAU - Palkonen, S
AU  - Palkonen S
FAU - Pin, I
AU  - Pin I
FAU - Pison, C
AU  - Pison C
FAU - Rance, F
AU  - Rance F
FAU - Reitamo, S
AU  - Reitamo S
FAU - Rial-Sebbag, E
AU  - Rial-Sebbag E
FAU - Salapatas, M
AU  - Salapatas M
FAU - Siroux, V
AU  - Siroux V
FAU - Smagghe, D
AU  - Smagghe D
FAU - Torrent, M
AU  - Torrent M
FAU - Toskala, E
AU  - Toskala E
FAU - van Cauwenberge, P
AU  - van Cauwenberge P
FAU - van Oosterhout, A J M
AU  - van Oosterhout AJ
FAU - Varraso, R
AU  - Varraso R
FAU - von Hertzen, L
AU  - von Hertzen L
FAU - Wickman, M
AU  - Wickman M
FAU - Wijmenga, C
AU  - Wijmenga C
FAU - Worm, M
AU  - Worm M
FAU - Wright, J
AU  - Wright J
FAU - Zuberbier, T
AU  - Zuberbier T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110124
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
SB  - IM
MH  - Cooperative Behavior
MH  - European Union
MH  - Humans
MH  - Hypersensitivity/diagnosis/drug therapy/*etiology/prevention & control
MH  - Medication Systems
MH  - Phenotype
MH  - Systems Biology
EDAT- 2011/01/26 06:00
MHDA- 2011/08/09 06:00
CRDT- 2011/01/26 06:00
PHST- 2011/01/26 06:00 [entrez]
PHST- 2011/01/26 06:00 [pubmed]
PHST- 2011/08/09 06:00 [medline]
AID - 10.1111/j.1398-9995.2010.02534.x [doi]
PST - ppublish
SO  - Allergy. 2011 May;66(5):596-604. doi: 10.1111/j.1398-9995.2010.02534.x. Epub 2011
      Jan 24.


PMID- 21258243
OWN - NLM
STAT- MEDLINE
DCOM- 20110621
LR  - 20110214
IS  - 1556-1380 (Electronic)
IS  - 1556-0864 (Linking)
VI  - 6
IP  - 3
DP  - 2011 Mar
TI  - Treatment of the elderly when cure is the goal: the influence of age on treatment
      selection and efficacy for stage III non-small cell lung cancer.
PG  - 537-44
LID - 10.1097/JTO.0b013e31820b8b9b [doi]
AB  - BACKGROUND: : Treatment of elderly patients with stage III NSCLC is
      controversial. Limited data exist, as the elderly are underrepresented in
      clinical trials. METHODS: : After ethics approval, we performed a retrospective
      review of 1372 stage III NSCLC patients treated at our institution during the
      period 1997-2007. Patients with malignant effusions and microscopic N2 discovered
      only postoperatively were excluded, leaving 740 who were classified by treatment 
      plan: palliative (palliative chemotherapy or radiation [</=40 Gy]); nonsurgical
      multimodality (>40 Gy radiation +/- chemotherapy); or surgical multimodality
      (chemotherapy, radiation, and surgery). Demographics, treatment, toxicity, and
      survival were analyzed by age, 0 to 65 years, n = 384; 66 to 75 years, n = 256;
      76+ years, n = 100, and compared using log-rank, univariate, and multivariate
      statistical tests. RESULTS: : Patients older than 65 years were more likely to
      have poor performance status (p < 0.0001), multiple comorbidities (p < 0.0001),
      and to receive palliative therapy only (p < 0.0001). Older and younger patients
      treated with curative intent with nonsurgical bimodality therapy or trimodality
      therapy including surgery had similar rates of grade 3/4 toxicity (0-65 years,
      39%; 66-75 years, 43%; 76+ years, 5%; p = 0.18) and toxic death (0-65 years, 4%; 
      66-75 years, 4%; 76+ years, 0%; p = 0.76). Survival was worse with increasing age
      (p < 0.0001), likely due to greater use of palliative treatment in the elderly.
      When survival was analyzed for patients treated with curative intent, there was
      no difference between age groups for nonsurgical (p = 0.32) or surgical (p =
      0.53) therapy. CONCLUSION: : In select fit elderly patients, combined modality
      therapy is tolerable and is associated with survival similar to that of younger
      patients.
FAU - Coate, Linda E
AU  - Coate LE
AD  - Department of Medical Oncology and Hematology, University Health Network,
      Princess Margaret Hospital, Toronto, Ontario, Canada.
FAU - Massey, Christine
AU  - Massey C
FAU - Hope, Andrew
AU  - Hope A
FAU - Sacher, Adrian
AU  - Sacher A
FAU - Barrett, Katherine
AU  - Barrett K
FAU - Pierre, Andrew
AU  - Pierre A
FAU - Leighl, Natasha
AU  - Leighl N
FAU - Brade, Anthony
AU  - Brade A
FAU - de Perrot, Marc
AU  - de Perrot M
FAU - Waddell, Tom
AU  - Waddell T
FAU - Liu, Geoffrey
AU  - Liu G
FAU - Feld, Ronald
AU  - Feld R
FAU - Burkes, Ronald
AU  - Burkes R
FAU - Cho, B C John
AU  - Cho BC
FAU - Darling, Gail
AU  - Darling G
FAU - Sun, Alexander
AU  - Sun A
FAU - Keshavjee, Shaf
AU  - Keshavjee S
FAU - Bezjak, Andrea
AU  - Bezjak A
FAU - Shepherd, Frances A
AU  - Shepherd FA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Thorac Oncol
JT  - Journal of thoracic oncology : official publication of the International
      Association for the Study of Lung Cancer
JID - 101274235
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Adenocarcinoma/therapy
MH  - Age Factors
MH  - Aged
MH  - Antineoplastic Agents/*therapeutic use
MH  - Carcinoma, Large Cell/therapy
MH  - Carcinoma, Non-Small-Cell Lung/*therapy
MH  - Carcinoma, Squamous Cell/therapy
MH  - Combined Modality Therapy
MH  - Comorbidity
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Lung Neoplasms/*therapy
MH  - Male
MH  - Neoplasm Staging
MH  - Palliative Care
MH  - *Pneumonectomy
MH  - Radiotherapy Dosage
MH  - *Research Design
MH  - Retrospective Studies
MH  - Survival Rate
MH  - Treatment Outcome
EDAT- 2011/01/25 06:00
MHDA- 2011/06/22 06:00
CRDT- 2011/01/25 06:00
PHST- 2011/01/25 06:00 [entrez]
PHST- 2011/01/25 06:00 [pubmed]
PHST- 2011/06/22 06:00 [medline]
AID - 10.1097/JTO.0b013e31820b8b9b [doi]
AID - S1556-0864(15)32209-7 [pii]
PST - ppublish
SO  - J Thorac Oncol. 2011 Mar;6(3):537-44. doi: 10.1097/JTO.0b013e31820b8b9b.


PMID- 21258236
OWN - NLM
STAT- MEDLINE
DCOM- 20110414
LR  - 20181201
IS  - 1528-1175 (Electronic)
IS  - 0003-3022 (Linking)
VI  - 114
IP  - 3
DP  - 2011 Mar
TI  - Remifentanil degradation in umbilical cord blood of preterm infants.
PG  - 570-7
LID - 10.1097/ALN.0b013e318204e043 [doi]
AB  - BACKGROUND: No pharmacokinetic data about remifentanil in preterm infants exist, 
      although remifentanil is increasingly used in this especially vulnerable subgroup
      of pediatric patients. Unfortunately, ethical restrictions in the volume of blood
      that can be withdrawn for kinetic sampling nearly prohibit pharmacokinetic
      studies in preterm infants. METHODS: Because remifentanil is rapidly metabolized 
      by nonspecific blood esterases, we collected umbilical cord serum of preterm and 
      term infants to investigate whether the activity of nonspecific blood esterases
      depends on gestational age. Umbilical cord serum, buffer solution, ascorbic acid,
      and remifentanil were mixed in a glass vial placed in a shaking water bath at 37 
      degrees C. Subsequently, serum samples were subjected to liquid
      chromatography-mass spectrometry-based analysis of remifentanil and its
      metabolite GR90291 after 0, 30, 60, 100, and 150 min. RESULTS: We analyzed
      umbilical cord serum samples of 34 preterm infants (24-36 gestational weeks) and 
      six term infants. The degradation rates of remifentanil to its major metabolite
      GR90291 were comparable in preterm and term infants. The overall median
      degradation half-life of remifentanil was 143 +/- (interquartile range) 47 min
      (minimum, 76 min; maximum, 221 min) without significant differences between very 
      preterm infants (less than 28 gestational weeks) and term infants. The
      remifentanil concentration remained stable in control runs without serum.
      CONCLUSIONS: Our study demonstrates that very preterm infants exhibit a high
      nonspecific esterase activity in umbilical cord blood that is comparable with
      that of term infants. These results support clinical experiences that
      remifentanil is rapidly metabolized by preterm infants without prolonged side
      effects.
FAU - Welzing, Lars
AU  - Welzing L
AD  - Department of Neonatology and Pediatric Intensive Care, University Hospital of
      Cologne, Cologne, Germany. lars.welzing@uk-koeln.de
FAU - Ebenfeld, Sabine
AU  - Ebenfeld S
FAU - Dlugay, Verena
AU  - Dlugay V
FAU - Wiesen, Martin H J
AU  - Wiesen MH
FAU - Roth, Bernhard
AU  - Roth B
FAU - Mueller, Carsten
AU  - Mueller C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Anesthesiology
JT  - Anesthesiology
JID - 1300217
RN  - 0 (Anesthetics, Intravenous)
RN  - 0 (Indicators and Reagents)
RN  - 0 (Piperidines)
RN  - P10582JYYK (Remifentanil)
SB  - IM
MH  - Algorithms
MH  - Anesthetics, Intravenous/*blood/pharmacokinetics
MH  - Biotransformation
MH  - Chromatography, High Pressure Liquid
MH  - Female
MH  - Fetal Blood/*chemistry
MH  - Gestational Age
MH  - Half-Life
MH  - Humans
MH  - Indicators and Reagents
MH  - Infant, Newborn
MH  - Infant, Premature/*metabolism
MH  - Male
MH  - Piperidines/*blood/pharmacokinetics
MH  - Remifentanil
MH  - Tandem Mass Spectrometry
EDAT- 2011/01/25 06:00
MHDA- 2011/04/16 06:00
CRDT- 2011/01/25 06:00
PHST- 2011/01/25 06:00 [entrez]
PHST- 2011/01/25 06:00 [pubmed]
PHST- 2011/04/16 06:00 [medline]
AID - 10.1097/ALN.0b013e318204e043 [doi]
PST - ppublish
SO  - Anesthesiology. 2011 Mar;114(3):570-7. doi: 10.1097/ALN.0b013e318204e043.


PMID- 21257280
OWN - NLM
STAT- MEDLINE
DCOM- 20110701
LR  - 20220331
IS  - 1873-5134 (Electronic)
IS  - 0738-3991 (Linking)
VI  - 82
IP  - 3
DP  - 2011 Mar
TI  - Sharing qualitative research findings with participants: study experiences of
      methodological and ethical dilemmas.
PG  - 389-95
LID - 10.1016/j.pec.2010.12.016 [doi]
AB  - OBJECTIVE: Sharing qualitative research findings with participants, namely
      member-check, is perceived as a procedure designed to enhance study credibility
      and participant involvement. It is rarely used, however, and its methodological
      usefulness and ethical problems have been questioned. This article explores
      benefits and risks in applying member-check when studying healthcare topics,
      questioning the way it should be performed. METHODS: We discuss researchers'
      experiences in applying member-check, using four examples from three different
      studies: healthcare-providers' experiences of working with sexual-abuse
      survivors; adolescents' exposure to domestic-violence, and delivering and
      receiving bad news. RESULTS: Methodological and ethical difficulties can arise
      when performing member-check, challenging the day-to-day researcher-participant
      experience, and potentially, the physician-patient relationship. CONCLUSION:
      Applying member-check in healthcare settings is complex. Although this strategy
      has good intentions, it is not necessarily the best method for achieving
      credibility. Harm can be caused to participants, researchers and the
      doctor-patient relationship, risking researchers' commitment to ethical
      principles. PRACTICE IMPLICATIONS: Because participants' experience regarding
      member-check is difficult to predict, such a procedure should be undertaken
      cautiously. Prior to initiating member-check, researchers should ask themselves
      whether such a procedure is potentially risky for participants; and if anonymity 
      cannot be guaranteed, use alternative procedures when needed.
CI  - Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Goldblatt, Hadass
AU  - Goldblatt H
AD  - Department of Nursing, University of Haifa, Israel. goldblat@research.haifa.ac.il
FAU - Karnieli-Miller, Orit
AU  - Karnieli-Miller O
FAU - Neumann, Melanie
AU  - Neumann M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110122
PL  - Ireland
TA  - Patient Educ Couns
JT  - Patient education and counseling
JID - 8406280
MH  - Adolescent
MH  - Confidentiality
MH  - Ethics, Research
MH  - *Health Communication
MH  - Humans
MH  - Interviews as Topic
MH  - *Qualitative Research
MH  - Researcher-Subject Relations/*ethics
EDAT- 2011/01/25 06:00
MHDA- 2011/07/02 06:00
CRDT- 2011/01/25 06:00
PHST- 2010/07/30 00:00 [received]
PHST- 2010/12/14 00:00 [revised]
PHST- 2010/12/17 00:00 [accepted]
PHST- 2011/01/25 06:00 [entrez]
PHST- 2011/01/25 06:00 [pubmed]
PHST- 2011/07/02 06:00 [medline]
AID - S0738-3991(10)00788-3 [pii]
AID - 10.1016/j.pec.2010.12.016 [doi]
PST - ppublish
SO  - Patient Educ Couns. 2011 Mar;82(3):389-95. doi: 10.1016/j.pec.2010.12.016. Epub
      2011 Jan 22.


PMID- 21257086
OWN - NLM
STAT- MEDLINE
DCOM- 20110606
LR  - 20161125
IS  - 1879-291X (Electronic)
IS  - 0301-5629 (Linking)
VI  - 37
IP  - 2
DP  - 2011 Feb
TI  - Guidance on reporting ultrasound exposure conditions for bio-effects studies.
PG  - 177-83
LID - 10.1016/j.ultrasmedbio.2010.10.021 [doi]
AB  - This guidance is intended to encourage best practice among researchers into
      ultrasound bio-effects in terms of how they determine and report the exposure
      conditions used in their studies. It covers both diagnostic and therapeutic
      applications of ultrasound and is intended to be useful to the researchers
      themselves, to the review boards of ethical and funding committees and to the
      editors and reviewers of scientific journals. Recommendations are made for
      reporting formats, depending on the information available, and level of the
      study.
CI  - Copyright (c) 2011 World Federation for Ultrasound in Medicine & Biology.
      Published by Elsevier Inc. All rights reserved.
FAU - ter Haar, Gail
AU  - ter Haar G
AD  - Safety Committee of the British Medical Ultrasound Society, UK.
      Gail.terHaar@icr.ac.uk
FAU - Shaw, Adam
AU  - Shaw A
FAU - Pye, Stephen
AU  - Pye S
FAU - Ward, Barry
AU  - Ward B
FAU - Bottomley, Fiona
AU  - Bottomley F
FAU - Nolan, Rachel
AU  - Nolan R
FAU - Coady, Anne-Marie
AU  - Coady AM
LA  - eng
PT  - Guideline
PT  - Journal Article
PT  - Review
PL  - England
TA  - Ultrasound Med Biol
JT  - Ultrasound in medicine & biology
JID - 0410553
SB  - IM
MH  - *Diagnostic Imaging
MH  - Humans
MH  - Pressure
MH  - Temperature
MH  - Ultrasonography/adverse effects/*methods
MH  - United Kingdom
EDAT- 2011/01/25 06:00
MHDA- 2011/06/07 06:00
CRDT- 2011/01/25 06:00
PHST- 2009/11/01 00:00 [received]
PHST- 2010/10/16 00:00 [revised]
PHST- 2010/10/19 00:00 [accepted]
PHST- 2011/01/25 06:00 [entrez]
PHST- 2011/01/25 06:00 [pubmed]
PHST- 2011/06/07 06:00 [medline]
AID - S0301-5629(10)00570-3 [pii]
AID - 10.1016/j.ultrasmedbio.2010.10.021 [doi]
PST - ppublish
SO  - Ultrasound Med Biol. 2011 Feb;37(2):177-83. doi:
      10.1016/j.ultrasmedbio.2010.10.021.


PMID- 21257024
OWN - NLM
STAT- MEDLINE
DCOM- 20110330
LR  - 20220316
IS  - 1525-3198 (Electronic)
IS  - 0022-0302 (Linking)
VI  - 94
IP  - 2
DP  - 2011 Feb
TI  - Invited review: ruminating conscientiously: scientific and socio-ethical
      challenges for US dairy production.
PG  - 539-46
LID - 10.3168/jds.2010-3627 [doi]
AB  - Despite the predominantly positive depictions of dairy production, public concern
      about farm animal production practices in the United States is currently higher
      than at any point in recent history. Many standard industry practices, including 
      some used by the US dairy industries, are increasingly challenged not just on
      scientific grounds, but also on ethical grounds. Concerns include the
      environmental impacts and sustainability of modern farm animal production
      practices, food safety and security, and the increasingly complex issue of animal
      welfare. As the impetus increases to achieve broad stakeholder engagement in
      discussions of US food policy, understanding and addressing the ethical concerns 
      associated with contemporary dairy production is critically important to ensure
      the industry's autonomy and long-term viability. Animal welfare assessment or
      accountability tools such as the Ethical Matrix or Campbell's Ethics Assessment
      Process can provide a structured, transparent method of making appropriate
      ethical choices about the care and welfare of farm animals that are also
      scientifically grounded.
CI  - Copyright A(c) 2011 American Dairy Science Association. Published by Elsevier
      Inc. All rights reserved.
FAU - Croney, C C
AU  - Croney CC
AD  - Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The
      Ohio State University, Columbus 43210, USA. croney.1@osu.edu
FAU - Anthony, R
AU  - Anthony R
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Dairy Sci
JT  - Journal of dairy science
JID - 2985126R
SB  - IM
MH  - Animal Husbandry/standards
MH  - Animal Welfare/*ethics
MH  - Animals
MH  - Cattle
MH  - Dairying/*ethics/methods
MH  - Nutrition Policy
MH  - United States
EDAT- 2011/01/25 06:00
MHDA- 2011/03/31 06:00
CRDT- 2011/01/25 06:00
PHST- 2010/07/15 00:00 [received]
PHST- 2010/10/14 00:00 [accepted]
PHST- 2011/01/25 06:00 [entrez]
PHST- 2011/01/25 06:00 [pubmed]
PHST- 2011/03/31 06:00 [medline]
AID - S0022-0302(11)00002-6 [pii]
AID - 10.3168/jds.2010-3627 [doi]
PST - ppublish
SO  - J Dairy Sci. 2011 Feb;94(2):539-46. doi: 10.3168/jds.2010-3627.


PMID- 21256859
OWN - NLM
STAT- MEDLINE
DCOM- 20120619
LR  - 20220309
IS  - 1095-6808 (Electronic)
IS  - 0091-3022 (Linking)
VI  - 33
IP  - 1
DP  - 2012 Jan
TI  - Acute effects of steroid hormones and neuropeptides on human social-emotional
      behavior: a review of single administration studies.
PG  - 17-35
LID - 10.1016/j.yfrne.2011.01.002 [doi]
AB  - Steroids and peptides mediate a diverse array of animal social behaviors. Human
      research is restricted by technical-ethical limitations, and models of the
      neuroendocrine regulation of social-emotional behavior are therefore mainly
      limited to non-human species, often under the assumption that human
      social-emotional behavior is emancipated from hormonal control. Development of
      acute hormone administration procedures in human research, together with the
      advent of novel non-invasive neuroimaging techniques, have opened up
      opportunities to systematically study the neuroendocrinology of human
      social-emotional behavior. Here, we review all placebo-controlled single hormone 
      administration studies addressing human social-emotional behavior, involving the 
      steroids testosterone and estradiol, and the peptides oxytocin and vasopressin.
      These studies demonstrate substantial hormonal control over human
      social-emotional behavior and give insights into the underlying neural
      mechanisms. Finally, we propose a theoretical model that synthesizes detailed
      knowledge of the neuroendocrinology of social-emotional behavior in animals with 
      the recently gained data from humans described in our review.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Bos, Peter A
AU  - Bos PA
AD  - Department of Experimental Psychology, Utrecht University, Heidelberglaan 2, 3584
      CS, Utrecht, The Netherlands. p.a.bos@uu.nl
FAU - Panksepp, Jaak
AU  - Panksepp J
FAU - Bluthe, Rose-Marie
AU  - Bluthe RM
FAU - van Honk, Jack
AU  - van Honk J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110121
PL  - United States
TA  - Front Neuroendocrinol
JT  - Frontiers in neuroendocrinology
JID - 7513292
RN  - 11000-17-2 (Vasopressins)
RN  - 113-79-1 (Arginine Vasopressin)
RN  - 3XMK78S47O (Testosterone)
RN  - 4TI98Z838E (Estradiol)
RN  - 50-56-6 (Oxytocin)
SB  - IM
MH  - Aggression/drug effects
MH  - Animals
MH  - Arginine Vasopressin/physiology
MH  - Emotions/*drug effects
MH  - Empathy/drug effects
MH  - Estradiol/*physiology
MH  - Humans
MH  - Models, Neurological
MH  - Object Attachment
MH  - Oxytocin/*physiology
MH  - *Social Behavior
MH  - Social Perception
MH  - Testosterone/*physiology
MH  - Vasopressins/*physiology
EDAT- 2011/01/25 06:00
MHDA- 2012/06/20 06:00
CRDT- 2011/01/25 06:00
PHST- 2010/10/18 00:00 [received]
PHST- 2010/12/21 00:00 [revised]
PHST- 2011/01/18 00:00 [accepted]
PHST- 2011/01/25 06:00 [entrez]
PHST- 2011/01/25 06:00 [pubmed]
PHST- 2012/06/20 06:00 [medline]
AID - S0091-3022(11)00016-1 [pii]
AID - 10.1016/j.yfrne.2011.01.002 [doi]
PST - ppublish
SO  - Front Neuroendocrinol. 2012 Jan;33(1):17-35. doi: 10.1016/j.yfrne.2011.01.002.
      Epub 2011 Jan 21.


PMID- 21256478
OWN - NLM
STAT- MEDLINE
DCOM- 20110803
LR  - 20110405
IS  - 1578-147X (Electronic)
IS  - 0009-739X (Linking)
VI  - 89
IP  - 4
DP  - 2011 Apr
TI  - [Biobanks and use of samples of human origin for surgical research. Current
      regulatory framework].
PG  - 207-12
LID - 10.1016/j.ciresp.2010.07.014 [doi]
AB  - In recent years, there has been a growing interest in the development of
      biological samples and biobanks that make it easier for investigators to have
      access to quality samples and their associated clinical and epidemiological data.
      Thus, biobanks have become indispensible technological platforms for the
      development of both basic and clinical research. The properties of the biological
      sample as a support medium of personal and family information require that they
      are treated in accordance with new ethical standards. For this reason, the Law on
      Biomedical Research, provides a new regulatory framework in the process of
      obtaining samples and their storage for research purposes, where the consent of
      the source subject, data protection, the favourable opinion of a Research Ethics 
      Committee, the prior taking out of an insurance policy against possible adverse
      effects, and the quality and safety requirements in the handling and management
      of these materials are key elements.
CI  - Copyright (c) 2010 AEC. Published by Elsevier Espana. All rights reserved.
FAU - Martin Arribas, Maria Concepcion
AU  - Martin Arribas MC
AD  - Comite de Etica de Investigacion y Bienestar Animal. Instituto de Salud Carlos
      III (ISCIII), Madrid, Espana. comartin@isciii.es
FAU - Arias Diaz, Javier
AU  - Arias Diaz J
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Biobancos y utilizacion de muestras de origen humano en investigacion quirurgica.
      Marco normativo actual.
DEP - 20110121
PL  - Spain
TA  - Cir Esp
JT  - Cirugia espanola
JID - 1254104
SB  - IM
MH  - Biological Specimen Banks/ethics/*legislation & jurisprudence
MH  - Biomedical Research/ethics/*legislation & jurisprudence
MH  - Humans
MH  - Informed Consent
MH  - Spain
MH  - Tissue and Organ Procurement/ethics/*legislation & jurisprudence
EDAT- 2011/01/25 06:00
MHDA- 2011/08/04 06:00
CRDT- 2011/01/25 06:00
PHST- 2010/06/18 00:00 [received]
PHST- 2010/07/29 00:00 [revised]
PHST- 2010/07/30 00:00 [accepted]
PHST- 2011/01/25 06:00 [entrez]
PHST- 2011/01/25 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
AID - S0009-739X(10)00444-6 [pii]
AID - 10.1016/j.ciresp.2010.07.014 [doi]
PST - ppublish
SO  - Cir Esp. 2011 Apr;89(4):207-12. doi: 10.1016/j.ciresp.2010.07.014. Epub 2011 Jan 
      21.


PMID- 21256362
OWN - NLM
STAT- MEDLINE
DCOM- 20110623
LR  - 20110124
IS  - 1528-3968 (Electronic)
IS  - 0029-6554 (Linking)
VI  - 59
IP  - 1
DP  - 2011 Jan-Feb
TI  - Linking service-learning with community-based participatory research: an
      interprofessional course for health professional students.
PG  - 47-54
LID - 10.1016/j.outlook.2010.10.001 [doi]
AB  - Service-learning is a valued strategy for educating health professionals. Linking
      service-learning with community-based participatory research (CBPR) engages
      students with community stakeholders and faculty in a collaborative process to
      bring about social change and improved health. The purpose of this paper is to
      describe a strategy for involving interprofessional students in ongoing faculty
      CBPR in an underserved community. The process includes the design and
      implementation of a course that combines weekly seminars with field experiences
      in the targeted community, emphasizing community assessment, and working with
      community members to find solutions to health problems. Nursing, public health,
      and medical students were recruited to the initial course, and offered the
      opportunity to meet objectives of required components of their disciplinary
      curriculum. Community members became actively involved in educating students
      while working to solve identified health problems. Important principles of
      CBPR--trust, collaboration, excellence in science, and ethics--are emphasized
      throughout the initiative. This course is now a regular offering for
      interprofessional students, providing valuable learning experiences for students,
      faculty, and the community. Ongoing faculty CBPR continues a trusting
      community-academic relationship and gives the community a voice in the solution
      for health problems.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Marcus, Marianne T
AU  - Marcus MT
AD  - Center of Substance Abuse Education, Prevention, and Research, The University of 
      Texas Health Science Center at Houston, School of Nursing, Houston, TX 77030,
      USA. Marianne.T.Marcus@uth.tmc.edu
FAU - Taylor, Wendell C
AU  - Taylor WC
FAU - Hormann, Mark D
AU  - Hormann MD
FAU - Walker, Thomas
AU  - Walker T
FAU - Carroll, Deidra
AU  - Carroll D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Nurs Outlook
JT  - Nursing outlook
JID - 0401075
SB  - IM
MH  - Clinical Nursing Research/*education/ethics
MH  - *Community Health Services
MH  - Cooperative Behavior
MH  - *Curriculum/standards
MH  - Educational Measurement
MH  - Environment
MH  - Health Education/ethics/*methods
MH  - Humans
MH  - Trust
EDAT- 2011/01/25 06:00
MHDA- 2011/06/24 06:00
CRDT- 2011/01/25 06:00
PHST- 2010/06/25 00:00 [received]
PHST- 2010/09/28 00:00 [revised]
PHST- 2010/10/07 00:00 [accepted]
PHST- 2011/01/25 06:00 [entrez]
PHST- 2011/01/25 06:00 [pubmed]
PHST- 2011/06/24 06:00 [medline]
AID - S0029-6554(10)00407-0 [pii]
AID - 10.1016/j.outlook.2010.10.001 [doi]
PST - ppublish
SO  - Nurs Outlook. 2011 Jan-Feb;59(1):47-54. doi: 10.1016/j.outlook.2010.10.001.


PMID- 21255713
OWN - NLM
STAT- MEDLINE
DCOM- 20110506
LR  - 20131121
IS  - 1878-3449 (Electronic)
IS  - 0749-2081 (Linking)
VI  - 27
IP  - 1
DP  - 2011 Feb
TI  - Ethical, legal, psychosocial, and cultural implications of genomics for oncology 
      nurses.
PG  - 54-63
LID - 10.1016/j.soncn.2010.11.007 [doi]
AB  - OBJECTIVES: To summarize the role of oncology nurses in the ethical, legal,
      psychosocial, and cultural issues inherent in genetic testing for hereditary
      cancer risk and to describe the recent trend and implications of
      direct-to-consumer genetic tests. DATA SOURCES: Published articles/books, legal
      rulings, professional organization statements. CONCLUSIONS: Ethical, legal,
      psychosocial, and cultural implications are inherent in the growing field of
      genetic science that is transforming modern health care. IMPLICATIONS FOR NURSING
      PRACTICE: Nurses have a duty to be knowledgeable about and advocate for the
      ethical integration of genetic/genomic information into their patient's health
      care.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Twomey, John
AU  - Twomey J
AD  - School of Nursing, and Ethics Education, MGH Institute of Health Professions,
      Massachusetts General Hospital, Boston, MA, USA. jtwomey@mghihp.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Semin Oncol Nurs
JT  - Seminars in oncology nursing
JID - 8504688
SB  - IM
MH  - *Clinical Competence
MH  - Cultural Characteristics
MH  - Ethics, Nursing
MH  - Female
MH  - Forecasting
MH  - *Genetic Testing
MH  - Genomics/*methods
MH  - Humans
MH  - Liability, Legal
MH  - Male
MH  - Neoplasms/genetics/*nursing
MH  - Nurse's Role
MH  - Oncology Nursing/education/*ethics
MH  - Psychology
EDAT- 2011/01/25 06:00
MHDA- 2011/05/07 06:00
CRDT- 2011/01/25 06:00
PHST- 2011/01/25 06:00 [entrez]
PHST- 2011/01/25 06:00 [pubmed]
PHST- 2011/05/07 06:00 [medline]
AID - S0749-2081(10)00089-6 [pii]
AID - 10.1016/j.soncn.2010.11.007 [doi]
PST - ppublish
SO  - Semin Oncol Nurs. 2011 Feb;27(1):54-63. doi: 10.1016/j.soncn.2010.11.007.


PMID- 21254370
OWN - NLM
STAT- MEDLINE
DCOM- 20120103
LR  - 20111118
IS  - 1545-5017 (Electronic)
IS  - 1545-5009 (Linking)
VI  - 57
IP  - 7
DP  - 2011 Dec 15
TI  - Parental views on tissue banking in pediatric oncology patients.
PG  - 1217-21
LID - 10.1002/pbc.22716 [doi]
AB  - PURPOSE: Research using banked tissue is key to advancing risk-stratification and
      treatment of children with cancer. Knowledge of parental attitudes to ethical
      issues arising in tissue banking is very limited but essential in obtaining
      respectful consent. METHODS: One hundred parents of consecutively diagnosed
      children with cancer were offered a validated 34-item questionnaire. RESULTS:
      Respondents (n = 54) included 10 of 16 parents of deceased children. The majority
      (89%; n = 48) would agree to have tissue sent anywhere in the world but prefer
      pediatric aims (69%). Most (98%; n = 53) would permit genetic research, if it
      might improve the child's health, and 76% (n = 41) would permit it, even if no
      impact was anticipated. A minority (41%) would not allow painful, strictly
      research procedures, while 15% would regardless of the child's dissent. Just over
      half (54%; n = 29) wish to renew consent if stored tissue is used for another
      purpose. Most (98%) believe their child should confirm consent by the age of
      majority, but only 71% believe the mature child should be able to withdraw
      consent. A minority (n = 40; 74%) claim few or no rights to research profits; 83%
      believe these should be used to fund childhood cancer research. CONCLUSIONS:
      Parents are very supportive of tissue research, including genetic research. A
      majority of parents would prefer restricting research to pediatric conditions,
      and to be informed of results, even if of uncertain significance. These findings 
      may assist Institutional Review Boards in assessing parentally perceived risks of
      research, and researchers in providing consent elements that support parents and 
      adolescents in making fully informed choices.
CI  - Copyright (c) 2011 Wiley Periodicals, Inc.
FAU - McMurter, Britney
AU  - McMurter B
AD  - Department of Kinesiology, Dalhousie University, IWK Health Centre, Halifax, Nova
      Scotia, Canada.
FAU - Parker, Louise
AU  - Parker L
FAU - Fraser, Robert B
AU  - Fraser RB
FAU - Magee, J Fergall
AU  - Magee JF
FAU - Kozancyzn, Christa
AU  - Kozancyzn C
FAU - Fernandez, Conrad V
AU  - Fernandez CV
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110119
PL  - United States
TA  - Pediatr Blood Cancer
JT  - Pediatric blood & cancer
JID - 101186624
SB  - IM
MH  - Adolescent
MH  - Biomedical Research/ethics
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Infant
MH  - Male
MH  - *Neoplasms
MH  - Parental Consent/*ethics
MH  - Parents/*psychology
MH  - Pediatrics/ethics
MH  - Tissue Banks/*ethics
EDAT- 2011/01/22 06:00
MHDA- 2012/01/04 06:00
CRDT- 2011/01/22 06:00
PHST- 2009/12/20 00:00 [received]
PHST- 2010/05/24 00:00 [accepted]
PHST- 2011/01/22 06:00 [entrez]
PHST- 2011/01/22 06:00 [pubmed]
PHST- 2012/01/04 06:00 [medline]
AID - 10.1002/pbc.22716 [doi]
PST - ppublish
SO  - Pediatr Blood Cancer. 2011 Dec 15;57(7):1217-21. doi: 10.1002/pbc.22716. Epub
      2011 Jan 19.


PMID- 21253848
OWN - NLM
STAT- MEDLINE
DCOM- 20120419
LR  - 20220311
IS  - 1573-6571 (Electronic)
IS  - 0022-4197 (Linking)
VI  - 50
IP  - 4
DP  - 2011 Dec
TI  - 'There is a time to be born and a time to die' (Ecclesiastes 3:2a): Jewish
      perspectives on euthanasia.
PG  - 778-95
LID - 10.1007/s10943-011-9465-9 [doi]
AB  - Reviewing the publications of prominent American rabbis who have (extensively)
      published on Jewish biomedical ethics, this article highlights Orthodox,
      Conservative and Reform opinions on a most pressing contemporary bioethical
      issue: euthanasia. Reviewing their opinions against the background of the
      halachic character of Jewish (biomedical) ethics, this article shows how from one
      traditional Jewish textual source diverse, even contradictory, opinions emerge
      through different interpretations. In this way, in the Jewish debate on
      euthanasia the specific methodology of Jewish (bio)ethical reasoning comes
      forward as well as a diversity of opinion within Judaism and its branches.
FAU - Baeke, Goedele
AU  - Baeke G
AD  - Faculty of Theology (Interdisciplinary Centre for the Study of Religion and World
      View), Katholieke Universiteit Leuven, Sint-Michielsstraat 4 bus 3101, 3000
      Leuven, Belgium. Goedele.Baeke@theo.kuleuven.be
FAU - Wils, Jean-Pierre
AU  - Wils JP
FAU - Broeckaert, Bert
AU  - Broeckaert B
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Relig Health
JT  - Journal of religion and health
JID - 2985199R
SB  - IM
MH  - Cultural Characteristics
MH  - Euthanasia, Active
MH  - Health Behavior
MH  - Humans
MH  - *Jews
MH  - *Judaism
MH  - *Religion and Medicine
MH  - *Religion and Psychology
MH  - *Right to Die
MH  - Social Responsibility
MH  - Social Values
MH  - Spirituality
MH  - United States
MH  - *Value of Life
PMC - PMC3230754
EDAT- 2011/01/22 06:00
MHDA- 2012/04/20 06:00
CRDT- 2011/01/22 06:00
PHST- 2011/01/22 06:00 [entrez]
PHST- 2011/01/22 06:00 [pubmed]
PHST- 2012/04/20 06:00 [medline]
AID - 10.1007/s10943-011-9465-9 [doi]
PST - ppublish
SO  - J Relig Health. 2011 Dec;50(4):778-95. doi: 10.1007/s10943-011-9465-9.


PMID- 21253839
OWN - NLM
STAT- MEDLINE
DCOM- 20111201
LR  - 20220330
IS  - 1573-3394 (Electronic)
IS  - 1065-3058 (Linking)
VI  - 19
IP  - 1
DP  - 2011 Mar
TI  - Mature care and nursing in psychiatry: notions regarding reciprocity in
      asymmetric professional relationships.
PG  - 65-76
LID - 10.1007/s10728-011-0167-y [doi]
AB  - The idea behind this article is to discuss the importance and to develop the
      concept of reciprocity in asymmetric professional relationships. As an empirical 
      starting point for an examination of the possible forms of reciprocity between
      patients and nurses in psychiatry, we chose two qualitative in-depth interviews
      with two different patients. The manners in which these two patients relate to
      medical personnel--one is dependent, the other is independent--show that this
      presents challenges to nurses. The theoretical context is provided by the notion 
      of mature care as it has been developed by feminist-oriented ethics of care, in
      contrast to the notion of altruistic care. In relation to the concept of mature
      care, we discuss how nursing can be perceived in demanding relationships with
      patients in psychiatry. Reciprocity implies that, in principle, the interests of 
      the nurses also matter in a nurse-patient relationship. We show that
      reciprocity--in practice--is complicated and challenging in a number of different
      ways. Mature care--with its systematic inclusion of relationships and
      reciprocity--provides an alternative understanding of what takes place between
      patients and nurses compared with an altruistic notion of care. As such, mature
      care can be regarded as an useful paradigm for nurse-patient relationships in
      psychiatry.
FAU - Hem, Marit Helene
AU  - Hem MH
AD  - Center for Medical Ethics, Faculty of Medicine, University of Oslo, Blindern, PO 
      Box 1130, 0318 Oslo, Norway. m.h.hem@medisin.uio.no
FAU - Pettersen, Tove
AU  - Pettersen T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Health Care Anal
JT  - Health care analysis : HCA : journal of health philosophy and policy
JID - 9432537
MH  - Altruism
MH  - Attitude of Health Personnel
MH  - Humans
MH  - Mental Disorders/*nursing
MH  - Nurse's Role
MH  - *Nurse-Patient Relations
MH  - Patient Care/*methods
MH  - Psychiatry/*methods
MH  - Qualitative Research
PMC - PMC3037490
EDAT- 2011/01/22 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/01/22 06:00
PHST- 2011/01/22 06:00 [entrez]
PHST- 2011/01/22 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/s10728-011-0167-y [doi]
PST - ppublish
SO  - Health Care Anal. 2011 Mar;19(1):65-76. doi: 10.1007/s10728-011-0167-y.


PMID- 21252850
OWN - NLM
STAT- MEDLINE
DCOM- 20110621
LR  - 20110121
IS  - 0026-4970 (Print)
IS  - 0026-4970 (Linking)
VI  - 60
IP  - 1-2
DP  - 2011 Jan-Feb
TI  - Occlusion and temporomandibular disorders: a malpractice case with medical legal 
      considerations.
PG  - 65-74
AB  - Occlusion and temporomandibular The issue of temporomandibular disorders (TMD)
      diagnosis and treatment has become a matter of increasing interest in the medical
      legal field in recent years. The old-fashioned theories based on the occlusal
      paradigm was proven to be erroneous, and clinicians who still provide
      irreversible treatments to TMD patients have to be conscious of the potential
      legal consequences of their behavior. The present paper described an illustrative
      case report of a patient to whom extensive and irreversible occlusal therapies
      were performed with the unique aim to provide relief from TMD symptoms. The
      treatment was unsuccessful and the dental practitioner was called into cause for 
      a professional liability claim. The clinician was judged guilty of malpractice on
      the basis of the lack of scientific evidence of the irreversible occlusal
      approaches to TMD, which were erroneously used and did not give the patient any
      benefit, thus forcing him to a non necessary financial and biological cost. The
      failure to satisfy the contract with the patient, which is usually not covered by
      any insurance company, forced the practitioner to give the money back to the
      patient. The ethical and legal implications of such case were discussed, with
      particular focus on the concept that medical legal advices need to satisfy the
      highest standards of evidence and have to be strictly based on scientific
      knowledge.
FAU - Bucci, M B
AU  - Bucci MB
AD  - Private Pratictioner, La Spezia, Italy. buccibb@alice.it
FAU - Aversa, M
AU  - Aversa M
FAU - Guarda-Nardini, L
AU  - Guarda-Nardini L
FAU - Manfredini, D
AU  - Manfredini D
LA  - eng
LA  - ita
PT  - Case Reports
PT  - Journal Article
PL  - Italy
TA  - Minerva Stomatol
JT  - Minerva stomatologica
JID - 0421071
RN  - 0 (Dental Implants)
SB  - IM
MH  - Contracts
MH  - Dental Implants/economics
MH  - Denture, Partial, Fixed/economics
MH  - Evidence-Based Medicine
MH  - Humans
MH  - Male
MH  - *Malpractice
MH  - Middle Aged
MH  - *Occlusal Adjustment/economics/ethics
MH  - Occlusal Splints/economics
MH  - Patient Satisfaction
MH  - Reoperation/economics
MH  - Temporomandibular Joint Disorders/diagnosis/economics/*surgery/therapy
MH  - Tooth Extraction/economics/ethics
MH  - *Unnecessary Procedures/economics/ethics
EDAT- 2011/01/22 06:00
MHDA- 2011/06/22 06:00
CRDT- 2011/01/22 06:00
PHST- 2011/01/22 06:00 [entrez]
PHST- 2011/01/22 06:00 [pubmed]
PHST- 2011/06/22 06:00 [medline]
AID - R18113209 [pii]
PST - ppublish
SO  - Minerva Stomatol. 2011 Jan-Feb;60(1-2):65-74.


PMID- 21252333
OWN - NLM
STAT- MEDLINE
DCOM- 20110208
LR  - 20220309
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Linking)
VI  - 331
IP  - 6015
DP  - 2011 Jan 21
TI  - Research ethics. Research practice and participant preferences: the growing gulf.
PG  - 287-8
LID - 10.1126/science.1199000 [doi]
FAU - Trinidad, S B
AU  - Trinidad SB
AD  - Department of Bioethics and Humanities, University of Washington, Seattle, WA
      98185, USA. sbtrini@uw.edu
FAU - Fullerton, S M
AU  - Fullerton SM
FAU - Ludman, E J
AU  - Ludman EJ
FAU - Jarvik, G P
AU  - Jarvik GP
FAU - Larson, E B
AU  - Larson EB
FAU - Burke, W
AU  - Burke W
LA  - eng
GR  - U01-HG-004610/HG/NHGRI NIH HHS/United States
GR  - U01 HG006375/HG/NHGRI NIH HHS/United States
GR  - U01 HG004610-01/HG/NHGRI NIH HHS/United States
GR  - U01 AG006781/AG/NIA NIH HHS/United States
GR  - U01 HG004610/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
SB  - IM
CIN - Science. 2011 Apr 15;332(6027):306; author reply 306. PMID: 21493845
MH  - *Biological Specimen Banks
MH  - Electronic Health Records
MH  - Ethics, Research
MH  - Genetic Research/*ethics
MH  - *Genomics
MH  - Humans
MH  - *Information Dissemination
MH  - *Informed Consent
MH  - Policy
MH  - Public Opinion
MH  - Researcher-Subject Relations
PMC - PMC3044500
MID - NIHMS269833
EDAT- 2011/01/22 06:00
MHDA- 2011/02/09 06:00
CRDT- 2011/01/22 06:00
PHST- 2011/01/22 06:00 [entrez]
PHST- 2011/01/22 06:00 [pubmed]
PHST- 2011/02/09 06:00 [medline]
AID - 331/6015/287 [pii]
AID - 10.1126/science.1199000 [doi]
PST - ppublish
SO  - Science. 2011 Jan 21;331(6015):287-8. doi: 10.1126/science.1199000.


PMID- 21251940
OWN - NLM
STAT- MEDLINE
DCOM- 20110923
LR  - 20110606
IS  - 1872-8294 (Electronic)
IS  - 0169-409X (Linking)
VI  - 63
IP  - 7
DP  - 2011 Jun 19
TI  - Ethical, legal, and social implications (ELSI) of microdose clinical trials.
PG  - 503-10
LID - 10.1016/j.addr.2011.01.002 [doi]
AB  - A "microdose clinical trial" (microdosing) is one kind of early phase exploratory
      clinical trial, administering the compound at doses estimated to have no
      pharmacological or toxicological effects, aimed at screening candidates for
      further clinical development. This article's objective is to clarify the ethical,
      legal, and social implications (ELSI) of such an exploratory minimum-risk human
      trial. The definition and non-clinical study requirements for microdosing have
      been harmonized among the European Union (EU), United States (US), and Japan.
      Being conducted according to these regulations, microdosing seems to be ethically
      well justified in terms of respect for persons, beneficence, justice, human
      dignity, and animal welfare. Three big projects have been demonstrating the
      predictability of therapeutic dose pharmacokinetics from microdosing. The article
      offers suggestions as how microdosing can become a more useful and socially
      accepted strategy.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Kurihara, Chieko
AU  - Kurihara C
AD  - Molecular Imaging Center, National Institute of Radiological Sciences, Anagawa
      4-9-1, Inage, Chiba 263-8555 Japan. chieko.kurihara@nifty.ne.jp
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110118
PL  - Netherlands
TA  - Adv Drug Deliv Rev
JT  - Advanced drug delivery reviews
JID - 8710523
RN  - 0 (Drugs, Investigational)
SB  - IM
MH  - Animals
MH  - Clinical Trials, Phase I as Topic/ethics/legislation & jurisprudence/*methods
MH  - Dose-Response Relationship, Drug
MH  - *Drug Design
MH  - Drugs, Investigational/*administration & dosage/pharmacokinetics
MH  - European Union
MH  - Humans
MH  - Internationality
MH  - Japan
MH  - United States
EDAT- 2011/01/22 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/01/22 06:00
PHST- 2010/08/16 00:00 [received]
PHST- 2010/11/14 00:00 [revised]
PHST- 2011/01/07 00:00 [accepted]
PHST- 2011/01/22 06:00 [entrez]
PHST- 2011/01/22 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - S0169-409X(11)00006-8 [pii]
AID - 10.1016/j.addr.2011.01.002 [doi]
PST - ppublish
SO  - Adv Drug Deliv Rev. 2011 Jun 19;63(7):503-10. doi: 10.1016/j.addr.2011.01.002.
      Epub 2011 Jan 18.


PMID- 21251881
OWN - NLM
STAT- MEDLINE
DCOM- 20111202
LR  - 20110314
IS  - 1873-281X (Electronic)
IS  - 1472-9792 (Linking)
VI  - 91
IP  - 2
DP  - 2011 Mar
TI  - Tuberculosis in prisons in sub-Saharan Africa--the need for improved health
      services, surveillance and control.
PG  - 173-8
LID - 10.1016/j.tube.2010.12.002 [doi]
AB  - Prisons have long been associated with rapid transmission of infectious diseases.
      The HIV/AIDS epidemic in sub-Saharan Africa (SSA) has fuelled the spread of TB
      and HIV in prisons. The poor living conditions and ineffective health services in
      prisons in SSA are a major breeding ground of Mycobacterium tuberculosis (Mtb).
      The spread of TB between prisoners, prison staff and visitors and the emergence
      of drug-resistant TB in prisons now poses a threat to control efforts of national
      TB programmes in SSA. Accurate data required to develop appropriate interventions
      to tackle the ominous problem of TB in African prisons are scanty and unreliable.
      The health of prisoners is by default a neglected political issue. This article
      reviews the available literature on TB and drug-resistant TB in prisons from SSA 
      countries, discusses the risk factors for acquiring TB and highlights the
      priorities for further translational research in prisons. Ethical issues
      pertaining to research on captive African populations are discussed. Scientific, 
      political and funder attention is required urgently to improve prison health
      services.
CI  - Copyright (c) 2010. Published by Elsevier Ltd.
FAU - O'Grady, Justin
AU  - O'Grady J
AD  - Department of Infection, University College London Medical School, Windeyer
      Institute, 46 Cleveland Street, London W1T 4JF, UK.
FAU - Hoelscher, Michael
AU  - Hoelscher M
FAU - Atun, Rifat
AU  - Atun R
FAU - Bates, Matthew
AU  - Bates M
FAU - Mwaba, Peter
AU  - Mwaba P
FAU - Kapata, Nathan
AU  - Kapata N
FAU - Ferrara, Giovanni
AU  - Ferrara G
FAU - Maeurer, Markus
AU  - Maeurer M
FAU - Zumla, Alimuddin
AU  - Zumla A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110120
PL  - Scotland
TA  - Tuberculosis (Edinb)
JT  - Tuberculosis (Edinburgh, Scotland)
JID - 100971555
SB  - IM
MH  - Africa South of the Sahara/epidemiology
MH  - Biomedical Research/ethics
MH  - *Health Services Needs and Demand
MH  - Humans
MH  - Population Surveillance/methods
MH  - Prisons/standards/*statistics & numerical data
MH  - Tuberculosis/*epidemiology/prevention & control/transmission
MH  - Tuberculosis, Multidrug-Resistant/epidemiology/transmission
EDAT- 2011/01/22 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/01/22 06:00
PHST- 2010/10/21 00:00 [received]
PHST- 2010/11/14 00:00 [revised]
PHST- 2010/12/11 00:00 [accepted]
PHST- 2011/01/22 06:00 [entrez]
PHST- 2011/01/22 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S1472-9792(10)00141-1 [pii]
AID - 10.1016/j.tube.2010.12.002 [doi]
PST - ppublish
SO  - Tuberculosis (Edinb). 2011 Mar;91(2):173-8. doi: 10.1016/j.tube.2010.12.002. Epub
      2011 Jan 20.


PMID- 21251763
OWN - NLM
STAT- MEDLINE
DCOM- 20110630
LR  - 20141120
IS  - 1532-2777 (Electronic)
IS  - 0306-9877 (Linking)
VI  - 76
IP  - 4
DP  - 2011 Apr
TI  - Therapeutic cloning by xenotransplanted oocytes, supplemented with species
      specific reprogramming factors.
PG  - 527-9
LID - 10.1016/j.mehy.2010.12.008 [doi]
AB  - For therapeutic medication, a lot of work has been done regarding human embryonic
      stem (ES) cell lines derivation, but immunorejection is a major dilemma of this
      cell based therapy. Since long time, derivation of patient matched stem cells
      have been hoped to overcome this problem. Oocytes after nuclear transfer are the 
      most reliable source for patient matched ES cells derivation, for therapeutic
      use. In humans, utilization of oocytes for stem cell research raises sensitive
      logistical and ethical questions; primarily surrounding participation of women as
      oocyte donors. It has been claimed that therapeutic cloning would lead to
      commercial exploitation of poor women. On the other hand, the therapeutic promise
      of embryonic stem cell is so huge that there is a strong incentive to find some
      alternate sources of human oocytes. Here we propose to utilize the cross species 
      oocytes supplemented with human ES cellular extracts to establish patient
      specific ES cell lines.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Riaz, Amjad
AU  - Riaz A
AD  - University of Veterinary and Animal Sciences, Lahore, Pakistan.
      dramjadriaz@gmail.com
FAU - Javeed, Aqeel
AU  - Javeed A
FAU - Zhou, Qi
AU  - Zhou Q
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110119
PL  - United States
TA  - Med Hypotheses
JT  - Medical hypotheses
JID - 7505668
SB  - IM
MH  - Animals
MH  - Cell Line
MH  - Cellular Reprogramming/*genetics
MH  - Embryonic Stem Cells/*physiology
MH  - Female
MH  - Humans
MH  - Oocytes/*physiology/*transplantation
MH  - *Transplantation, Heterologous
EDAT- 2011/01/22 06:00
MHDA- 2011/07/01 06:00
CRDT- 2011/01/22 06:00
PHST- 2010/08/06 00:00 [received]
PHST- 2010/12/18 00:00 [accepted]
PHST- 2011/01/22 06:00 [entrez]
PHST- 2011/01/22 06:00 [pubmed]
PHST- 2011/07/01 06:00 [medline]
AID - S0306-9877(10)00520-7 [pii]
AID - 10.1016/j.mehy.2010.12.008 [doi]
PST - ppublish
SO  - Med Hypotheses. 2011 Apr;76(4):527-9. doi: 10.1016/j.mehy.2010.12.008. Epub 2011 
      Jan 19.


PMID- 21251293
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1478-4491 (Electronic)
IS  - 1478-4491 (Linking)
VI  - 9
DP  - 2011 Jan 20
TI  - Reflections on the ethics of recruiting foreign-trained human resources for
      health.
PG  - 2
LID - 10.1186/1478-4491-9-2 [doi]
AB  - BACKGROUND: Developed countries' gains in health human resources (HHR) from
      developing countries with significantly lower ratios of health workers have
      raised questions about the ethics or fairness of recruitment from such countries.
      By attracting and/or facilitating migration for foreign-trained HHR, notably
      those from poorer, less well-resourced nations, recruitment practices and
      policies may be compromising the ability of developing countries to meet the
      health care needs of their own populations. Little is known, however, about
      actual recruitment practices. In this study we focus on Canada (a country with a 
      long reliance on internationally trained HHR) and recruiters working for Canadian
      health authorities. METHODS: We conducted interviews with health human resources 
      recruiters employed by Canadian health authorities to describe their recruitment 
      practices and perspectives and to determine whether and how they reflect ethical 
      considerations. RESULTS AND DISCUSSION: We describe the methods that recruiters
      used to recruit foreign-trained health professionals and the systemic challenges 
      and policies that form the working context for recruiters and recruits. HHR
      recruiters' reflections on the global flow of health workers from poorer to
      richer countries mirror much of the content of global-level discourse with regard
      to HHR recruitment. A predominant market discourse related to shortages of HHR
      outweighed discussions of human rights and ethical approaches to recruitment
      policy and action that consider global health impacts. CONCLUSIONS: We suggest
      that the concept of corporate social responsibility may provide a useful approach
      at the local organizational level for developing policies on ethical recruitment.
      Such local policies and subsequent practices may inform public debate on the
      health equity implications of the HHR flows from poorer to richer countries
      inherent in the global health worker labour market, which in turn could influence
      political choices at all government and health system levels.
FAU - Runnels, Vivien
AU  - Runnels V
AD  - Globalization and Health Equity Research Unit, Institute of Population Health,
      University of Ottawa, Canada. rlabonte@uottawa.ca.
FAU - Labonte, Ronald
AU  - Labonte R
FAU - Packer, Corinne
AU  - Packer C
LA  - eng
PT  - Journal Article
DEP - 20110120
PL  - England
TA  - Hum Resour Health
JT  - Human resources for health
JID - 101170535
PMC - PMC3032656
EDAT- 2011/01/22 06:00
MHDA- 2011/01/22 06:01
CRDT- 2011/01/22 06:00
PHST- 2010/05/17 00:00 [received]
PHST- 2011/01/20 00:00 [accepted]
PHST- 2011/01/22 06:00 [entrez]
PHST- 2011/01/22 06:00 [pubmed]
PHST- 2011/01/22 06:01 [medline]
AID - 1478-4491-9-2 [pii]
AID - 10.1186/1478-4491-9-2 [doi]
PST - epublish
SO  - Hum Resour Health. 2011 Jan 20;9:2. doi: 10.1186/1478-4491-9-2.


PMID- 21251143
OWN - NLM
STAT- MEDLINE
DCOM- 20110524
LR  - 20211020
IS  - 1542-474X (Electronic)
IS  - 1082-720X (Linking)
VI  - 16
IP  - 1
DP  - 2011 Jan
TI  - A statement on ethics from the HEART group.
PG  - 107-9
LID - 10.1111/j.1542-474X.2010.00415.x [doi]
CN  - HEART Group
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Noninvasive Electrocardiol
JT  - Annals of noninvasive electrocardiology : the official journal of the
      International Society for Holter and Noninvasive Electrocardiology, Inc
JID - 9607443
SB  - IM
MH  - Cardiology
MH  - Disclosure
MH  - Editorial Policies
MH  - *Ethics, Research
MH  - Humans
MH  - Publishing/*ethics
PMC - PMC6932043
IR  - Ector H
FIR - Ector, Hugo
IR  - Lancellotti P
FIR - Lancellotti, Patrizio
IR  - Roberts WC
FIR - Roberts, William C
IR  - Wenger NK
FIR - Wenger, Nanette K
IR  - Moss AJ
FIR - Moss, Arthur J
IR  - Smith ER
FIR - Smith, Eldon R
IR  - Borer JS
FIR - Borer, Jeffrey S
IR  - Eagle KA
FIR - Eagle, Kim A
IR  - Freedman J
FIR - Freedman, Jane
IR  - Krum H
FIR - Krum, Henry
IR  - Lang C
FIR - Lang, Chim
IR  - Remme WJ
FIR - Remme, Willem J
IR  - Piper HM
FIR - Piper, Hans Michael
IR  - White CJ
FIR - White, Christopher J
IR  - Loscalzo J
FIR - Loscalzo, Joseph
IR  - Marban E
FIR - Marban, Eduardo
IR  - Sobel BE
FIR - Sobel, Burton E
IR  - Roberts R
FIR - Roberts, Robert
IR  - Rahimtoola SH
FIR - Rahimtoola, Shahbudin H
IR  - Camm AJ
FIR - Camm, A John
IR  - Van de Werf F
FIR - Van de Werf, Frans
IR  - Swedberg K
FIR - Swedberg, Karl
IR  - Timmis AD
FIR - Timmis, Adam D
IR  - Stone KS
FIR - Stone, Kathleen S
IR  - Zipes DP
FIR - Zipes, Douglas P
IR  - Iosseliani DG
FIR - Iosseliani, David G
IR  - Taylor AJ
FIR - Taylor, Allen J
IR  - Rosen MR
FIR - Rosen, Michael R
IR  - Grines CL
FIR - Grines, Cindy L
IR  - DeMaria AN
FIR - DeMaria, Anthony N
IR  - Narula J
FIR - Narula, Jagat
IR  - King SB 3rd
FIR - King, Spencer B 3rd
IR  - Wagner GS
FIR - Wagner, Galen S
IR  - Saksena S
FIR - Saksena, Sanjeev
IR  - Pearlman AS
FIR - Pearlman, Alan S
IR  - Bodnar E
FIR - Bodnar, Endre
IR  - Emery RW
FIR - Emery, Robert W
IR  - Cohn LH
FIR - Cohn, Lawrence H
IR  - van der Wall EE
FIR - van der Wall, Ernst E
IR  - Abdulla RI
FIR - Abdulla, Ra-id
IR  - Lesch M
FIR - Lesch, Michael
IR  - Alfonso F
FIR - Alfonso, Fernando
IR  - Ekroth R
FIR - Ekroth, Rolf
EDAT- 2011/01/22 06:00
MHDA- 2011/05/25 06:00
CRDT- 2011/01/22 06:00
PHST- 2011/01/22 06:00 [entrez]
PHST- 2011/01/22 06:00 [pubmed]
PHST- 2011/05/25 06:00 [medline]
AID - 10.1111/j.1542-474X.2010.00415.x [doi]
PST - ppublish
SO  - Ann Noninvasive Electrocardiol. 2011 Jan;16(1):107-9. doi:
      10.1111/j.1542-474X.2010.00415.x.


PMID- 21250931
OWN - NLM
STAT- MEDLINE
DCOM- 20110701
LR  - 20141120
IS  - 1362-3095 (Electronic)
IS  - 0955-3002 (Linking)
VI  - 87
IP  - 5
DP  - 2011 May
TI  - Sensitivity of porcine peripheral blood leukocytes to gamma irradiation in vivo, 
      in vitro and ex vivo.
PG  - 491-8
LID - 10.3109/09553002.2011.548437 [doi]
AB  - PURPOSE: The large white pig is a useful experimental model to compare in vivo,
      in vitro and ex vivo sensitivity of peripheral blood leukocytes to ionising
      radiation. Such studies are impossible to perform in humans and laboratory
      rodents due to ethical reasons and body size, respectively. We analysed dose- and
      time-dependent changes of lymphocyte and granulocyte absolute numbers in porcine 
      peripheral blood after either whole-body irradiation (in vivo and ex vivo
      experiments) or exposure of porcine whole blood to gamma-irradiation (in vitro
      experiments). MATERIALS AND METHODS: CytoCount absolute counting beads and light 
      scatter analysis using a flow cytometer were used to determine major leukocyte
      subpopulation numbers in blood samples after red cell removal. RESULTS: Similar
      to other species, lymphocyte numbers significantly decreased in pigs both in vivo
      and in vitro in a dose-dependent manner. Most importantly, our data clearly show 
      that reduction of lymphocyte numbers after irradiation in vivo proceeds much
      faster than after irradiation in vitro and that granulocyte changes depend only
      on the time of analysis after irradiation. CONCLUSIONS: All three tested
      experimental arrangements demonstrated the radiosensitivity of lymphocytes and
      the radioresistance of peripheral blood granulocytes. These in vivo and in vitro 
      approaches, as well as the newly introduced ex vivo observations, appear to be
      relevant to biodosimetry.
FAU - Zarybnicka, Lenka
AU  - Zarybnicka L
AD  - Department of Radiobiology, Faculty of Military Health Sciences, University of
      Defence, Trebesska, Czech Republic. zarybnicka@pmfhk.cz
FAU - Sinkorova, Zuzana
AU  - Sinkorova Z
FAU - Sinkora, Jiri
AU  - Sinkora J
FAU - Blaha, Vaclav
AU  - Blaha V
FAU - Vavrova, Jirina
AU  - Vavrova J
FAU - Pejchal, Jaroslav
AU  - Pejchal J
FAU - Osterreicher, Jan
AU  - Osterreicher J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110121
PL  - England
TA  - Int J Radiat Biol
JT  - International journal of radiation biology
JID - 8809243
SB  - IM
MH  - Animals
MH  - Cell Count/*methods
MH  - Dose-Response Relationship, Radiation
MH  - Flow Cytometry/methods
MH  - Gamma Rays
MH  - In Vitro Techniques
MH  - Leukocytes/*cytology/*radiation effects
MH  - Light
MH  - Radiation Tolerance
MH  - Radiation, Ionizing
MH  - Scattering, Radiation
MH  - Swine
MH  - Whole-Body Irradiation
EDAT- 2011/01/22 06:00
MHDA- 2011/07/02 06:00
CRDT- 2011/01/22 06:00
PHST- 2011/01/22 06:00 [entrez]
PHST- 2011/01/22 06:00 [pubmed]
PHST- 2011/07/02 06:00 [medline]
AID - 10.3109/09553002.2011.548437 [doi]
PST - ppublish
SO  - Int J Radiat Biol. 2011 May;87(5):491-8. doi: 10.3109/09553002.2011.548437. Epub 
      2011 Jan 21.


PMID- 21248662
OWN - NLM
STAT- MEDLINE
DCOM- 20110414
LR  - 20110221
IS  - 1534-6080 (Electronic)
IS  - 0041-1337 (Linking)
VI  - 91
IP  - 5
DP  - 2011 Mar 15
TI  - New organ transplant policies in Japan, including the family-oriented priority
      donation clause.
PG  - 489-91
LID - 10.1097/TP.0b013e318205b3ab [doi]
AB  - The revised Organ Transplant Law in Japan that took effect in July 2010 allows
      organ procurement from brain-dead individuals, including children, only with
      family consent. The amended law also allows individuals to prioritize family
      members to receive their donated organs after death. This policy differs from the
      prioritization policy in Israel, which provides incentives to individuals who
      agree to help each other in society and rectifies the problem of free riders,
      individuals who are willing to accept an organ but refuse to donate. Despite
      these differences, however, the Japanese and Israeli policies have revealed new
      ethical dilemmas, including the fear of compromising fairness in organ
      allocation.
FAU - Aita, Kaoruko
AU  - Aita K
AD  - Global COE Program Death and Life Studies, Graduate School of Humanities and
      Sociology, The University of Tokyo, Tokyo, Japan. aitak-tky@umin.ac.jp
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
SB  - IM
MH  - Brain Death/legislation & jurisprudence
MH  - *Family
MH  - Health Policy/legislation & jurisprudence/*trends
MH  - Humans
MH  - Israel
MH  - Japan
MH  - *Living Donors/ethics/legislation & jurisprudence
MH  - Organ Transplantation/ethics/legislation & jurisprudence/*trends
MH  - Suicide/ethics/legislation & jurisprudence
MH  - Tissue and Organ Procurement/ethics/legislation & jurisprudence/trends
EDAT- 2011/01/21 06:00
MHDA- 2011/04/16 06:00
CRDT- 2011/01/21 06:00
PHST- 2011/01/21 06:00 [entrez]
PHST- 2011/01/21 06:00 [pubmed]
PHST- 2011/04/16 06:00 [medline]
AID - 10.1097/TP.0b013e318205b3ab [doi]
PST - ppublish
SO  - Transplantation. 2011 Mar 15;91(5):489-91. doi: 10.1097/TP.0b013e318205b3ab.


PMID- 21248601
OWN - NLM
STAT- MEDLINE
DCOM- 20110531
LR  - 20220408
IS  - 1938-808X (Electronic)
IS  - 1040-2446 (Linking)
VI  - 86
IP  - 3
DP  - 2011 Mar
TI  - The hidden and implicit curricula in cultural context: new insights from Doha and
      New York.
PG  - 321-5
LID - 10.1097/ACM.0b013e318208761d [doi]
AB  - The authors report their longitudinal experience teaching a clerkship in clinical
      ethics and palliative care at the Weill Cornell Medical College campuses in New
      York and Doha. This course uses participant observation and reflective practice
      to counteract the hidden curriculum when learning about clinical ethics and
      end-of-life care. The authors consider how this formal element of the curriculum 
      is influenced by the implicit and hidden curricula in different cultural contexts
      and how these differing venues affect communication and information exchange,
      using the anthropological concept of high- and low-context societies. The
      authors' analysis provides additional information on Weill Cornell's educational 
      efforts in the medical humanities, bioethics, and palliative care across the
      curriculum and across cultural settings. By contrasting high-context Doha, where 
      much information is culturally embedded and seemingly hidden, with low-context
      New York, where information is made overt, the authors theorize that in each
      setting, the proportion of implicit and explicit curricular elements is
      determined by the extramural cultural environment. They argue that there are many
      hidden and implicit curricula and that each is dependent on modes of
      communication in any given setting. They assert that these variations can be seen
      not only across differing societies but also, for example, among individual U.S. 
      medical schools because of local custom, history, or mission. Because these
      contextual factors influence the relative importance of what is implicit and
      explicit in the student's educational experience, medical educators need to be
      aware of their local cultural contexts in order to engage in effective pedagogy.
FAU - Fins, Joseph J
AU  - Fins JJ
AD  - Division of Medical Ethics, Weill Cornell Medical College, New York, New York
      10021, USA. jjfins@med.cornell.edu
FAU - Rodriguez del Pozo, Pablo
AU  - Rodriguez del Pozo P
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Acad Med
JT  - Academic medicine : journal of the Association of American Medical Colleges
JID - 8904605
SB  - IM
MH  - *Arab World
MH  - Clinical Clerkship/*organization & administration
MH  - Cross-Cultural Comparison
MH  - *Curriculum
MH  - Ethics, Clinical/*education
MH  - Humans
MH  - New York City
MH  - *Palliative Care
MH  - Qatar
MH  - Terminal Care
MH  - *Western World
EDAT- 2011/01/21 06:00
MHDA- 2011/06/01 06:00
CRDT- 2011/01/21 06:00
PHST- 2011/01/21 06:00 [entrez]
PHST- 2011/01/21 06:00 [pubmed]
PHST- 2011/06/01 06:00 [medline]
AID - 10.1097/ACM.0b013e318208761d [doi]
PST - ppublish
SO  - Acad Med. 2011 Mar;86(3):321-5. doi: 10.1097/ACM.0b013e318208761d.


PMID- 21248178
OWN - NLM
STAT- MEDLINE
DCOM- 20110830
LR  - 20110525
IS  - 1477-030X (Electronic)
IS  - 0269-2163 (Linking)
VI  - 25
IP  - 4
DP  - 2011 Jun
TI  - Withdrawal of mechanical ventilation in the home: a case report and review of the
      literature.
PG  - 378-81
LID - 10.1177/0269216310396113 [doi]
AB  - Once it has been determined that aggressive medical treatment can no longer meet 
      the goals of care for a ventilated patient, the process of withdrawing mechanical
      ventilation begins. This is a challenging clinical situation, drawing on the
      treating physician's skills including clinical decision making with consideration
      of the ethical and legal domains of practice, high level communication skills,
      intensive symptom control for the dying patient, and support for families
      throughout the episode, including bereavement. Central to the success of this
      process is recognition and respect for the needs and wishes of the patient and
      family. This case reports on the withdrawal of mechanical ventilation from a
      conscious patient in their own home, leading to death, following a prolonged
      hospital admission.
CI  - (c) The Author(s) 2011
FAU - Clinch, Alexandra
AU  - Clinch A
AD  - Department of Palliative Care, Royal Melbourne Hospital, Grattan St, Parkville,
      Victoria 3050, Australia. Alexandra.Clinch@mh.org.au
FAU - Le, Brian
AU  - Le B
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20110119
PL  - England
TA  - Palliat Med
JT  - Palliative medicine
JID - 8704926
SB  - IM
MH  - Aged
MH  - *Home Care Services, Hospital-Based
MH  - Humans
MH  - Male
MH  - *Respiration, Artificial
MH  - Terminal Care/methods
MH  - *Withholding Treatment
EDAT- 2011/01/21 06:00
MHDA- 2011/08/31 06:00
CRDT- 2011/01/21 06:00
PHST- 2011/01/21 06:00 [entrez]
PHST- 2011/01/21 06:00 [pubmed]
PHST- 2011/08/31 06:00 [medline]
AID - 0269216310396113 [pii]
AID - 10.1177/0269216310396113 [doi]
PST - ppublish
SO  - Palliat Med. 2011 Jun;25(4):378-81. doi: 10.1177/0269216310396113. Epub 2011 Jan 
      19.


PMID- 21247862
OWN - NLM
STAT- MEDLINE
DCOM- 20110531
LR  - 20211020
IS  - 1438-8871 (Electronic)
IS  - 1438-8871 (Linking)
VI  - 13
IP  - 1
DP  - 2011 Jan 19
TI  - Protected health information on social networking sites: ethical and legal
      considerations.
PG  - e8
LID - 10.2196/jmir.1590 [doi]
AB  - BACKGROUND: Social networking site use is increasingly common among emerging
      medical professionals, with medical schools even reporting disciplinary student
      expulsion. Medical professionals who use social networking sites have unique
      responsibilities since their postings could violate patient privacy. However, it 
      is unknown whether students and residents portray protected health information
      and under what circumstances or contexts. OBJECTIVE: The objective of our study
      was to document and describe online portrayals of potential patient privacy
      violations in the Facebook profiles of medical students and residents. METHODS: A
      multidisciplinary team performed two cross-sectional analyses at the University
      of Florida in 2007 and 2009 of all medical students and residents to see who had 
      Facebook profiles. For each identified profile, we manually scanned the entire
      profile for any textual or photographic representations of protected health
      information, such as portrayals of people, names, dates, or descriptions of
      procedures. RESULTS: Almost half of all eligible students and residents had
      Facebook profiles (49.8%, or n=1023 out of 2053). There were 12 instances of
      potential patient violations, in which students and residents posted photographs 
      of care they provided to individuals. No resident or student posted any
      identifiable patient information or likeness in text form. Each instance occurred
      in developing countries on apparent medical mission trips. These portrayals
      increased over time (1 in the 2007 cohort; 11 in 2009; P = .03). Medical students
      were more likely to have these potential violations on their profiles than
      residents (11 vs 1, P = .04), and there was no difference by gender. Photographs 
      included trainees interacting with identifiable patients, all children, or
      performing medical examinations or procedures such as vaccinations of children.
      CONCLUSIONS: While students and residents in this study are posting photographs
      that are potentially violations of patient privacy, they only seem to make this
      lapse in the setting of medical mission trips. Trainees need to learn to equate
      standards of patient privacy in all medical contexts using both legal and ethical
      arguments to maintain the highest professional principles. We propose three
      practical guidelines. First, there should be a legal resource for physicians
      traveling on medical mission trips such as an online list of local laws, or a
      telephone legal contact. Second, institutions that organize medical mission trips
      should plan an ethics seminar prior the departure on any trip since the legal and
      ethical implications may not be intuitive. Finally, at minimum, traveling
      physicians should apply the strictest legal precedent to any situation.
FAU - Thompson, Lindsay A
AU  - Thompson LA
AD  - University of Florida, Department of Pediatrics, Gainesville, FL, United States. 
      lathompson@peds.ufl.edu
FAU - Black, Erik
AU  - Black E
FAU - Duff, W Patrick
AU  - Duff WP
FAU - Paradise Black, Nicole
AU  - Paradise Black N
FAU - Saliba, Heidi
AU  - Saliba H
FAU - Dawson, Kara
AU  - Dawson K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110119
PL  - Canada
TA  - J Med Internet Res
JT  - Journal of medical Internet research
JID - 100959882
SB  - IM
MH  - Confidentiality/*ethics/*legislation & jurisprudence
MH  - *Consumer Health Information
MH  - Cross-Sectional Studies
MH  - Developing Countries
MH  - Humans
MH  - Internship and Residency
MH  - Medical Missions/ethics/legislation & jurisprudence
MH  - Physicians
MH  - *Social Support
MH  - Students, Medical
PMC - PMC3221358
EDAT- 2011/01/21 06:00
MHDA- 2011/06/01 06:00
CRDT- 2011/01/21 06:00
PHST- 2010/06/27 00:00 [received]
PHST- 2010/10/21 00:00 [accepted]
PHST- 2010/09/22 00:00 [revised]
PHST- 2011/01/21 06:00 [entrez]
PHST- 2011/01/21 06:00 [pubmed]
PHST- 2011/06/01 06:00 [medline]
AID - v13i1e8 [pii]
AID - 10.2196/jmir.1590 [doi]
PST - epublish
SO  - J Med Internet Res. 2011 Jan 19;13(1):e8. doi: 10.2196/jmir.1590.


PMID- 21247627
OWN - NLM
STAT- MEDLINE
DCOM- 20110317
LR  - 20220331
IS  - 1474-547X (Electronic)
IS  - 0140-6736 (Linking)
VI  - 377
IP  - 9762
DP  - 2011 Jan 22
TI  - Adjuvant tamoxifen and exemestane in early breast cancer (TEAM): a randomised
      phase 3 trial.
PG  - 321-31
LID - 10.1016/S0140-6736(10)62312-4 [doi]
AB  - BACKGROUND: Aromatase inhibitors improved disease-free survival compared with
      tamoxifen when given as an initial adjuvant treatment or after 2-3 years of
      tamoxifen to postmenopausal women with hormone-receptor-positive breast cancer.
      We therefore compared the long-term effects of exemestane monotherapy with
      sequential treatment (tamoxifen followed by exemestane). METHODS: The Tamoxifen
      Exemestane Adjuvant Multinational (TEAM) phase 3 trial was conducted in hospitals
      in nine countries. Postmenopausal women (median age 64 years, range 35-96) with
      hormone-receptor-positive breast cancer were randomly assigned in a 1:1 ratio to 
      open-label exemestane (25 mg once a day, orally) alone or following tamoxifen (20
      mg once a day, orally) for 5 years. Randomisation was by use of a
      computer-generated random permuted block method. The primary endpoint was
      disease-free survival (DFS) at 5 years. Main analyses were by intention to treat.
      The trial is registered with ClinicalTrials.gov, NCT00279448, NCT00032136, and
      NCT00036270; NTR 267; Ethics Commission Trial27/2001; and UMIN, C000000057.
      FINDINGS: 9779 patients were assigned to sequential treatment (n=4875) or
      exemestane alone (n=4904), and 4868 and 4898 were analysed by intention to treat,
      respectively. 4154 (85%) patients in the sequential group and 4186 (86%) in the
      exemestane alone group were disease free at 5 years (hazard ratio 0.97, 95% CI
      0.88-1.08; p=0.60). In the safety analysis, sequential treatment was associated
      with a higher incidence of gynaecological symptoms (942 [20%] of 4814 vs 523
      [11%] of 4852), venous thrombosis (99 [2%] vs 47 [1%]), and endometrial
      abnormalities (191 [4%] vs 19 [<1%]) than was exemestane alone. Musculoskeletal
      adverse events (2448 [50%] vs 2133 [44%]), hypertension (303 [6%] vs 219 [5%]),
      and hyperlipidaemia (230 [5%] vs 136 [3%]) were reported more frequently with
      exemestane alone. INTERPRETATION: Treatment regimens of exemestane alone or after
      tamoxifen might be judged to be appropriate options for postmenopausal women with
      hormone-receptor-positive early breast cancer. FUNDING: Pfizer.
CI  - Copyright A(c) 2011 Elsevier Ltd. All rights reserved.
FAU - van de Velde, Cornelis J H
AU  - van de Velde CJ
AD  - Leiden University Medical Centre, Leiden, Netherlands. c.j.h.van_de_velde@lumc.nl
FAU - Rea, Daniel
AU  - Rea D
FAU - Seynaeve, Caroline
AU  - Seynaeve C
FAU - Putter, Hein
AU  - Putter H
FAU - Hasenburg, Annette
AU  - Hasenburg A
FAU - Vannetzel, Jean-Michel
AU  - Vannetzel JM
FAU - Paridaens, Robert
AU  - Paridaens R
FAU - Markopoulos, Christos
AU  - Markopoulos C
FAU - Hozumi, Yasuo
AU  - Hozumi Y
FAU - Hille, Elysee T M
AU  - Hille ET
FAU - Kieback, Dirk G
AU  - Kieback DG
FAU - Asmar, Lina
AU  - Asmar L
FAU - Smeets, Jan
AU  - Smeets J
FAU - Nortier, Johan W R
AU  - Nortier JW
FAU - Hadji, Peyman
AU  - Hadji P
FAU - Bartlett, John M S
AU  - Bartlett JM
FAU - Jones, Stephen E
AU  - Jones SE
LA  - eng
SI  - ClinicalTrials.gov/NCT00032136
SI  - ClinicalTrials.gov/NCT00036270
SI  - ClinicalTrials.gov/NCT00279448
PT  - Clinical Trial, Phase III
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Lancet
JT  - Lancet (London, England)
JID - 2985213R
RN  - 0 (Androstadienes)
RN  - 0 (Antineoplastic Agents, Hormonal)
RN  - 0 (Receptors, Estrogen)
RN  - 0 (Receptors, Progesterone)
RN  - 094ZI81Y45 (Tamoxifen)
RN  - NY22HMQ4BX (exemestane)
SB  - IM
CIN - Lancet. 2011 Jan 22;377(9762):280-1. PMID: 21256370
MH  - Adenocarcinoma/metabolism/mortality/pathology/*therapy
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Androstadienes/*therapeutic use
MH  - Antineoplastic Agents, Hormonal/*therapeutic use
MH  - Breast Neoplasms/metabolism/mortality/pathology/*therapy
MH  - Disease-Free Survival
MH  - Early Diagnosis
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Postmenopause
MH  - Receptors, Estrogen/metabolism
MH  - Receptors, Progesterone/metabolism
MH  - Tamoxifen/*therapeutic use
EDAT- 2011/01/21 06:00
MHDA- 2011/03/18 06:00
CRDT- 2011/01/21 06:00
PHST- 2011/01/21 06:00 [entrez]
PHST- 2011/01/21 06:00 [pubmed]
PHST- 2011/03/18 06:00 [medline]
AID - S0140-6736(10)62312-4 [pii]
AID - 10.1016/S0140-6736(10)62312-4 [doi]
PST - ppublish
SO  - Lancet. 2011 Jan 22;377(9762):321-31. doi: 10.1016/S0140-6736(10)62312-4.


PMID- 21247565
OWN - NLM
STAT- MEDLINE
DCOM- 20110708
LR  - 20161229
IS  - 1879-3479 (Electronic)
IS  - 0020-7292 (Linking)
VI  - 113
IP  - 1
DP  - 2011 Apr
TI  - Ethical dilemmas in women's health in under-resourced settings.
PG  - 25-7
LID - 10.1016/j.ijgo.2010.10.022 [doi]
AB  - Ethical decision making in women's health presents a series of unique challenges 
      that are exacerbated considerably in under-resourced settings. Severe constraints
      on both autonomy and resources highlight limitations of principle-based ethics
      for addressing ethical dilemmas. Other useful ethical "tools" are considered in
      the context of 2 cases that emphasize the challenges to ethical decision making
      in under-resourced settings. The cases confront traditional notions of patient
      autonomy, highlight pervasive issues with regard to allocation of resources, and 
      demonstrate the difficulties encountered in the careful application of medical
      ethics.
CI  - Copyright (c) 2010 International Federation of Gynecology and Obstetrics.
      Published by Elsevier Ireland Ltd. All rights reserved.
FAU - Wilkinson, Jeffrey P
AU  - Wilkinson JP
AD  - Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, 
      USA. jeffrey.wilkinson@duke.edu
FAU - Lyerly, Anne D
AU  - Lyerly AD
FAU - Masenga, Gileard
AU  - Masenga G
FAU - Hayat, Sumera K
AU  - Hayat SK
FAU - Prabhu, Malavika
AU  - Prabhu M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110117
PL  - United States
TA  - Int J Gynaecol Obstet
JT  - International journal of gynaecology and obstetrics: the official organ of the
      International Federation of Gynaecology and Obstetrics
JID - 0210174
SB  - IM
MH  - Decision Making/*ethics
MH  - Ethics, Medical
MH  - Female
MH  - Health Resources
MH  - Humans
MH  - *Medically Underserved Area
MH  - Personal Autonomy
MH  - Women's Health/*ethics
EDAT- 2011/01/21 06:00
MHDA- 2011/07/09 06:00
CRDT- 2011/01/21 06:00
PHST- 2010/08/07 00:00 [received]
PHST- 2010/10/25 00:00 [revised]
PHST- 2010/12/16 00:00 [accepted]
PHST- 2011/01/21 06:00 [entrez]
PHST- 2011/01/21 06:00 [pubmed]
PHST- 2011/07/09 06:00 [medline]
AID - S0020-7292(10)00589-8 [pii]
AID - 10.1016/j.ijgo.2010.10.022 [doi]
PST - ppublish
SO  - Int J Gynaecol Obstet. 2011 Apr;113(1):25-7. doi: 10.1016/j.ijgo.2010.10.022.
      Epub 2011 Jan 17.


PMID- 21247483
OWN - NLM
STAT- MEDLINE
DCOM- 20110517
LR  - 20211020
IS  - 1824-7288 (Electronic)
IS  - 1720-8424 (Linking)
VI  - 37
DP  - 2011 Jan 19
TI  - Excellence in Family Paediatricians: the FIMP-MCRN (Medicines for Children
      Research Network) becomes a member of ENPR-EMA (European Network of Paediatric
      Research at the European Medicines Agency).
PG  - 7
LID - 10.1186/1824-7288-37-7 [doi]
AB  - One of the objectives of the Paediatric Regulation (EC) No 1901/2006, is to
      foster high quality ethical research on medicinal products to be used in
      children. To achieve this objective, the EMA is responsible for developing a
      European paediatric network of existing national and European networks and
      centres with specific expertise in research and clinical trials relating to
      paediatric medicines. The purpose of this article is to disseminate knowledge of 
      the structure and goals of ENPR-EMA and to highlight the cultural and
      organizational difficulties for its implementation.Following the publication of
      research quality requirements, a set of recognition criteria, which have to be
      fulfilled to become a member of ENPR-EMA were agreed. So far, 32 networks and
      centres (of 62 identified networks) submitted self-assessment reports indicating 
      whether or not they fulfill the agreed minimum criteria. Sixteen networks (26% of
      62 identified networks) fulfilled all minimum criteria and became therefore
      members of ENPR-EMA. The Family Paediatricians Medicines for Children Research
      Network (FIMP-MCRN), established with the aim of developing competence,
      infrastructure, networking and education for paediatric clinical trials, became
      member of the ENPR-EMA responding satisfactorily to all the points of the
      self-assessment report.
FAU - Napoleone, Ettore
AU  - Napoleone E
AD  - Piazza della Vittoria 14/A Campobasso 86100 ITALY. ettorenapoleone@tiscali.it
LA  - eng
PT  - Editorial
DEP - 20110119
PL  - England
TA  - Ital J Pediatr
JT  - Italian journal of pediatrics
JID - 101510759
SB  - IM
MH  - *Biomedical Research
MH  - Child
MH  - *Clinical Competence
MH  - Europe
MH  - Humans
MH  - *Pediatrics
MH  - Physicians, Family/*standards
MH  - *Societies, Medical
MH  - Workforce
PMC - PMC3037309
EDAT- 2011/01/21 06:00
MHDA- 2011/05/18 06:00
CRDT- 2011/01/21 06:00
PHST- 2011/01/04 00:00 [received]
PHST- 2011/01/19 00:00 [accepted]
PHST- 2011/01/21 06:00 [entrez]
PHST- 2011/01/21 06:00 [pubmed]
PHST- 2011/05/18 06:00 [medline]
AID - 1824-7288-37-7 [pii]
AID - 10.1186/1824-7288-37-7 [doi]
PST - epublish
SO  - Ital J Pediatr. 2011 Jan 19;37:7. doi: 10.1186/1824-7288-37-7.


PMID- 21246352
OWN - NLM
STAT- MEDLINE
DCOM- 20110727
LR  - 20211020
IS  - 1432-1041 (Electronic)
IS  - 0031-6970 (Linking)
VI  - 67 Suppl 1
DP  - 2011 May
TI  - Modelling and simulation as research tools in paediatric drug development.
PG  - 75-86
LID - 10.1007/s00228-010-0974-3 [doi]
AB  - PURPOSE: Although practical and ethical constraints impose special requirements
      for the evaluation of treatment safety and efficacy in children, the main issue
      remains the empirical basis for patient stratification and dose selection at the 
      early stage of the development of new chemical and biological entities. The aim
      of this review is to highlight the advantages and limitations of modelling and
      simulation (M&S) in supporting decision making during paediatric drug
      development. METHODS: A literature search on Pubmed's database Medical Subject
      Headings (MeSH) has been performed to retrieve relevant publications on the use
      of model-based approaches in paediatric drug development and therapeutics.
      RESULTS: M&S enable the assessment of the impact of different regimens as well as
      of different populations on a drug's safety and efficacy profile. It has been
      widely used in the last two decades to support pre-clinical and early clinical
      drug development. In fact, M&S have been applied to drug development as decision 
      tools, as study optimization tools and as data analysis tools. In particular,
      this approach can be used to support dose adjustment in specific subgroups of a
      population. M&S may therefore allow the individualisation of drug therapy in
      children, improving the risk-benefit ratio in this population. CONCLUSIONS: The
      lack of consensus on how to assess the impact of developmental factors on
      pharmacokinetics, pharmacodynamics, efficacy and safety has so far prevented a
      broader use of M&S. This problem is compounded by the limited collaboration
      between stakeholders, which prevents data sharing in this field. In this article,
      we emphasise the need for a concerted effort to promote the effective use of this
      technology in paediatric drug development and avoid unnecessary exposure of
      children to clinical trials.
FAU - Bellanti, Francesco
AU  - Bellanti F
AD  - Division of Pharmacology, Leiden/Amsterdam Center for Drug Research, Leiden, The 
      Netherlands.
FAU - Della Pasqua, Oscar
AU  - Della Pasqua O
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110119
PL  - Germany
TA  - Eur J Clin Pharmacol
JT  - European journal of clinical pharmacology
JID - 1256165
SB  - IM
MH  - Child
MH  - Clinical Trials as Topic/methods
MH  - Computer Simulation
MH  - *Drug Design
MH  - Humans
MH  - *Models, Biological
MH  - Pediatrics/*methods
MH  - Risk Assessment
PMC - PMC3082698
EDAT- 2011/01/20 06:00
MHDA- 2011/07/28 06:00
CRDT- 2011/01/20 06:00
PHST- 2010/11/30 00:00 [received]
PHST- 2010/12/02 00:00 [accepted]
PHST- 2011/01/20 06:00 [entrez]
PHST- 2011/01/20 06:00 [pubmed]
PHST- 2011/07/28 06:00 [medline]
AID - 10.1007/s00228-010-0974-3 [doi]
PST - ppublish
SO  - Eur J Clin Pharmacol. 2011 May;67 Suppl 1:75-86. doi: 10.1007/s00228-010-0974-3. 
      Epub 2011 Jan 19.


PMID- 21245017
OWN - NLM
STAT- MEDLINE
DCOM- 20110928
LR  - 20211020
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Linking)
VI  - 119
IP  - 6
DP  - 2011 Jun
TI  - DDT and malaria prevention: addressing the paradox.
PG  - 744-7
LID - 10.1289/ehp.1002127 [doi]
AB  - BACKGROUND: The debate regarding dichlorodiphenyltrichloroethane (DDT) in malaria
      prevention and human health is polarized and can be classified into three
      positions: anti-DDT, centrist-DDT, pro-DDT. OBJECTIVE: We attempted to arrive at 
      a synthesis by matching a series of questions on the use of DDT for indoor
      residual spraying (IRS) with literature and insights, and to identify options and
      opportunities. DISCUSSION: Overall, community health is significantly improved
      through all available malaria control measures, which include IRS with DDT. Is
      DDT "good"? Yes, because it has saved many lives. Is DDT safe as used in IRS?
      Recent publications have increasingly raised concerns about the health
      implications of DDT. Therefore, an unqualified statement that DDT used in IRS is 
      safe is untenable. Are inhabitants and applicators exposed? Yes, and to high
      levels. Should DDT be used? The fact that DDT is "good" because it saves lives,
      and "not safe" because it has health and environmental consequences, raises
      ethical issues. The evidence of adverse human health effects due to DDT is
      mounting. However, under certain circumstances, malaria control using DDT cannot 
      yet be halted. Therefore, the continued use of DDT poses a paradox recognized by 
      a centrist-DDT position. At the very least, it is now time to invoke precaution. 
      Precautionary actions could include use and exposure reduction. CONCLUSIONS:
      There are situations where DDT will provide the best achievable health benefit,
      but maintaining that DDT is safe ignores the cumulative indications of many
      studies. In such situations, addressing the paradox from a centrist-DDT position 
      and invoking precaution will help design choices for healthier lives.
FAU - Bouwman, Hindrik
AU  - Bouwman H
AD  - School of Environmental Sciences and Development, North-West University,
      Potchefstroom, South Africa. henk.bouwman@nwu.ac.za
FAU - van den Berg, Henk
AU  - van den Berg H
FAU - Kylin, Henrik
AU  - Kylin H
LA  - eng
PT  - Comment
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110118
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - 0 (Insecticides)
RN  - CIW5S16655 (DDT)
SB  - IM
CON - Environ Health Perspect. 2009 Aug;117(8):A344. PMID: 19672383
CON - Environ Health Perspect. 2009 Nov;117(11):1656-63. PMID: 20049114
CON - Environ Health Perspect. 2009 Dec;117(12):1809-13. PMID: 20049197
CON - Environ Health Perspect. 2010 Jan;118(1):A14-5; author reply A15-6. PMID:
      20238453
CIN - Environ Health Perspect. 2011 Oct;119(10):A423-4; author reply A424-5. PMID:
      21968389
MH  - DDT/toxicity
MH  - *Environmental Exposure
MH  - Humans
MH  - Insecticides/toxicity
MH  - Malaria/*prevention & control
MH  - *Mosquito Control
MH  - *Public Health
MH  - Risk Assessment
PMC - PMC3114806
EDAT- 2011/01/20 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/01/20 06:00
PHST- 2010/03/04 00:00 [received]
PHST- 2011/01/18 00:00 [accepted]
PHST- 2011/01/20 06:00 [entrez]
PHST- 2011/01/20 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 10.1289/ehp.1002127 [doi]
PST - ppublish
SO  - Environ Health Perspect. 2011 Jun;119(6):744-7. doi: 10.1289/ehp.1002127. Epub
      2011 Jan 18.


PMID- 21244569
OWN - NLM
STAT- MEDLINE
DCOM- 20110615
LR  - 20110721
IS  - 1460-9592 (Electronic)
IS  - 1155-5645 (Linking)
VI  - 21
IP  - 3
DP  - 2011 Mar
TI  - Role of modeling and simulation in pediatric investigation plans.
PG  - 214-21
LID - 10.1111/j.1460-9592.2011.03523.x [doi]
AB  - Ethical and practical constraints encourage the optimal use of resources in
      pediatric drug development. Modeling and simulation has emerged as a promising
      methodology acknowledged by industry, academia, and regulators. We previously
      proposed a paradigm in pediatric drug development, whereby modeling and
      simulation is used as a decision tool, for study optimization and/or as a data
      analysis tool. Three and a half years since the Paediatric Regulation came into
      force in 2007, the European Medicines Agency has gained substantial experience in
      the use of modeling and simulation in pediatric drug development. In this review,
      we present examples on how the proposed paradigm applies in real case scenarios
      of planned pharmaceutical developments. We also report the results of a pediatric
      database search to further 'validate' the paradigm. There were 47 of 210 positive
      pediatric investigation plan (PIP) opinions that made reference to modeling and
      simulation (data included all positive opinions issued up to January 2010). This 
      reflects a major shift in regulatory thinking. The ratio of PIPs with modeling
      and simulation rose to two in five based on the summary reports. Population
      pharmacokinetic (POP-PK) and pharmacodynamics (POP-PD) and physiologically based 
      pharmacokinetic models are widely used by industry and endorsed or even imposed
      by regulators as a way to circumvent some difficulties in developing medicinal
      products in children. The knowledge of the effects of age and size on PK is
      improving, and models are widely employed to make optimal use of this knowledge
      but less is known about the effects of size and maturation on PD, disease
      progression, and safety. Extrapolation of efficacy from different age groups is
      often used in pediatric medicinal development as another means to alleviate the
      burden of clinical trials in children, and this can be aided by modeling and
      simulation to supplement clinical data. The regulatory assessment is finally
      judged on clinical grounds such as feasibility, ethical issues, prioritization of
      studies, and unmet medical need. The regulators are eager to expand the use of
      modeling and simulation to elucidate safety issues, to evaluate the effects of
      disease (e.g., renal or hepatic dysfunction), and to qualify mechanistic models
      that could help shift the current medicinal development paradigm.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Manolis, Efthymios
AU  - Manolis E
AD  - European Medicines Agency, Canary Wharf, London, UK.
      Efthymios.Manolis@ema.europa.eu
FAU - Osman, Tariq Eldirdiry
AU  - Osman TE
FAU - Herold, Ralf
AU  - Herold R
FAU - Koenig, Franz
AU  - Koenig F
FAU - Tomasi, Paolo
AU  - Tomasi P
FAU - Vamvakas, Spiros
AU  - Vamvakas S
FAU - Saint Raymond, Agnes
AU  - Saint Raymond A
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110118
PL  - France
TA  - Paediatr Anaesth
JT  - Paediatric anaesthesia
JID - 9206575
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - *Computer Simulation
MH  - Databases, Factual
MH  - Drug Delivery Systems
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - *Models, Statistical
MH  - Pediatrics/*statistics & numerical data
MH  - Pharmacokinetics
MH  - Population
MH  - Research Design
EDAT- 2011/01/20 06:00
MHDA- 2011/06/16 06:00
CRDT- 2011/01/20 06:00
PHST- 2011/01/20 06:00 [entrez]
PHST- 2011/01/20 06:00 [pubmed]
PHST- 2011/06/16 06:00 [medline]
AID - 10.1111/j.1460-9592.2011.03523.x [doi]
PST - ppublish
SO  - Paediatr Anaesth. 2011 Mar;21(3):214-21. doi: 10.1111/j.1460-9592.2011.03523.x.
      Epub 2011 Jan 18.


PMID- 21244265
OWN - NLM
STAT- MEDLINE
DCOM- 20110502
LR  - 20110119
IS  - 1557-7740 (Electronic)
IS  - 1557-7740 (Linking)
VI  - 14
IP  - 1
DP  - 2011 Jan
TI  - The use of hospice care in end-stage psychiatric patients.
PG  - 107-8
LID - 10.1089/jpm.2009.0431 [doi]
AB  - Hospice care is rarely used in end-stage psychiatric patients, yet situations
      exist where psychiatric intervention is futile and comfort care is the best
      option. Delusional disorder is rare, typically begins later in life, and has a
      chronic course that responds poorly to treatment. The prognosis is affected by
      factors such as chronicity and insight. A case of a chronic and intractable
      delusional disorder that affected eating behavior and subsequently caused serious
      medical complications. Due to the severity of the case and the unique ethical
      issues it presented, the prognosis was determined to be poor and the patient was 
      discharged home with hospice care. The case presented a rare opportunity to
      assess hospice care provided to an end-stage psychiatric patient.
FAU - Bassirpour, Gillian
AU  - Bassirpour G
AD  - Department of Internal Medicine, University of Michigan, Ann Arbor Michigan, USA.
FAU - Mahr, Gregory
AU  - Mahr G
FAU - Lee, Bobby
AU  - Lee B
FAU - Torres, Maria
AU  - Torres M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Palliat Med
JT  - Journal of palliative medicine
JID - 9808462
SB  - IM
MH  - Chronic Disease
MH  - Female
MH  - *Hospice Care
MH  - Humans
MH  - Middle Aged
MH  - *Schizophrenia, Paranoid/physiopathology
EDAT- 2011/01/20 06:00
MHDA- 2011/05/03 06:00
CRDT- 2011/01/20 06:00
PHST- 2011/01/20 06:00 [entrez]
PHST- 2011/01/20 06:00 [pubmed]
PHST- 2011/05/03 06:00 [medline]
AID - 10.1089/jpm.2009.0431 [doi]
PST - ppublish
SO  - J Palliat Med. 2011 Jan;14(1):107-8. doi: 10.1089/jpm.2009.0431.


PMID- 21244199
OWN - NLM
STAT- MEDLINE
DCOM- 20110616
LR  - 20191210
IS  - 1943-2836 (Electronic)
IS  - 0020-7284 (Linking)
VI  - 61
IP  - 1
DP  - 2011 Jan
TI  - The ethics of trauma: re-traumatization in society's approach to the traumatized 
      subject.
PG  - 26-47
LID - 10.1521/ijgp.2011.61.1.26 [doi]
AB  - The paper starts from a question about the subconscious needs and anxieties which
      may underlie society's current responses to trauma. In particular, the author
      argues that the interest in the trauma of torture and man-made violence is a
      reaction to the increasingly dehumanizing and death-denying culture we live in.
      After proposing that the various categories of societal responses-the author
      focuses on evaluation, treatment, and advocacy-to traumatized subjects hide
      defenses of denial, distortion, refusal, with respect to the challenge of
      mortality, meaning-making, and mourning, the author then makes the thesis that
      they can derail and corrupt the project of post-traumatic repair. The paper
      proceeds with an examination of the ethics and politics that are implicit in
      contemporary North American society's current approach to trauma. The central
      argument is that the current approach may contain a collective acting out that
      often ends up being re-traumatizing to the traumatized subjects.
FAU - Nguyen, Leanh
AU  - Nguyen L
AD  - NYU Postdoctoral Program for Psychotherapy and Psychoanalysis, USA.
      ldnguyen.phd@gmail.com
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Group Psychother
JT  - International journal of group psychotherapy
JID - 0374720
SB  - IM
MH  - Attitude of Health Personnel
MH  - Crime Victims/psychology
MH  - *Denial, Psychological
MH  - Ethics, Clinical
MH  - Humans
MH  - Life Change Events
MH  - Mental Disorders/diagnosis/psychology/therapy
MH  - North America
MH  - Psychological Tests
MH  - Researcher-Subject Relations/*ethics/psychology
MH  - Societies, Medical/organization & administration
MH  - Sociology, Medical/ethics
MH  - Stress Disorders, Traumatic/*diagnosis/*psychology/therapy
MH  - Surveys and Questionnaires
MH  - Torture/*ethics/*psychology
EDAT- 2011/01/20 06:00
MHDA- 2011/06/17 06:00
CRDT- 2011/01/20 06:00
PHST- 2011/01/20 06:00 [entrez]
PHST- 2011/01/20 06:00 [pubmed]
PHST- 2011/06/17 06:00 [medline]
AID - 10.1521/ijgp.2011.61.1.26 [doi]
AID - 10.1521/ijgp.2011.61.1.26 [pii]
PST - ppublish
SO  - Int J Group Psychother. 2011 Jan;61(1):26-47. doi: 10.1521/ijgp.2011.61.1.26.


PMID- 21243539
OWN - NLM
STAT- MEDLINE
DCOM- 20110616
LR  - 20211020
IS  - 1534-6269 (Electronic)
IS  - 1523-3790 (Linking)
VI  - 13
IP  - 2
DP  - 2011 Apr
TI  - Endoscopic resection of sinonasal malignancies.
PG  - 138-44
LID - 10.1007/s11912-011-0151-6 [doi]
AB  - Malignant tumors of the sinonasal tract are rare, accounting for only 1% of all
      malignancies. Although they are associated with substantial histological
      heterogeneity, surgery plays a key role in their management. This review
      addresses the evolution of current treatments in view of the introduction of
      endoscopic resection techniques. The absence of facial incisions and osteotomies,
      decreased hospitalization time, better control of bleeding, improved
      visualization of tumor borders, and reduced morbidity and mortality rate are the 
      major advantages of endoscopic techniques in comparison to traditional external
      approaches. The major criticisms focus on oncologic results in view of the
      short/intermediate follow-up of large series, which have commonly grouped
      together several histologies that may be associated with different prognoses.
      Since prospective studies contrasting the results of endoscopic and craniofacial 
      resections are difficult to carry out given the rarity of the disease together
      with ethical issues, the creation of a large database would favor the analysis of
      several variables related to the patient, tumor, and treatment on survival
      performed on a large number of patients.
FAU - Nicolai, Piero
AU  - Nicolai P
AD  - Department of Otorhinolaryngology, University of Brescia, Piazza Spedali Civili
      1, 25123, Brescia, Italy. pieronicolai@virgilio.it
FAU - Castelnuovo, Paolo
AU  - Castelnuovo P
FAU - Bolzoni Villaret, Andrea
AU  - Bolzoni Villaret A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Oncol Rep
JT  - Current oncology reports
JID - 100888967
SB  - IM
MH  - Endoscopy/adverse effects/*methods
MH  - Humans
MH  - Nose Neoplasms/*surgery/*therapy
MH  - Paranasal Sinus Neoplasms/*surgery/*therapy
EDAT- 2011/01/19 06:00
MHDA- 2011/06/17 06:00
CRDT- 2011/01/19 06:00
PHST- 2011/01/19 06:00 [entrez]
PHST- 2011/01/19 06:00 [pubmed]
PHST- 2011/06/17 06:00 [medline]
AID - 10.1007/s11912-011-0151-6 [doi]
PST - ppublish
SO  - Curr Oncol Rep. 2011 Apr;13(2):138-44. doi: 10.1007/s11912-011-0151-6.


PMID- 21243484
OWN - NLM
STAT- MEDLINE
DCOM- 20110629
LR  - 20220331
IS  - 1433-3023 (Electronic)
IS  - 0937-3462 (Linking)
VI  - 22
IP  - 4
DP  - 2011 Apr
TI  - Injury of the corona mortis during vaginal tape insertion (TVT-Secur using the
      U-Approach).
PG  - 443-5
LID - 10.1007/s00192-010-1355-2 [doi]
AB  - INTRODUCTION AND HYPOTHESIS: We report a serious bleeding complication due to
      injury of the corona mortis following insertion of a transvaginal tape, TVT-Secur
      (Ethicon Women's Health, Sommerville, NJ, USA). METHODS: The TVT-Secur was
      inserted using the U-Approach: the tape was pushed along the periost behind the
      arc of the pubic bone at an angle of 45 degrees . RESULTS: Surgery was
      unproblematic. Four hours after surgery, the patient showed shock signs; a CT
      scan revealed a 13.5 x 9.5-cm-sized retrosymphysic haematoma. Instant laparotomy 
      with removal of the large haematoma, ligation of the bleeding corona mortis and
      administration of erythrocyte concentrates were necessary. CONCLUSION: The corona
      mortis is an anastomosis between the arteria obturatoria and the external iliac
      vessels or its branches that passes over the superior pubic ramus. Its prevalence
      and anatomical relation to the pubic bone are important to bear in mind when
      applying new surgical techniques.
FAU - Gobrecht, Ursula
AU  - Gobrecht U
AD  - Burgerspital Solothurn, 4500 Solothurn, Switzerland. ursula_gobrecht@hotmail.com
FAU - Kuhn, Annette
AU  - Kuhn A
FAU - Fellman, Bernhard
AU  - Fellman B
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20110118
PL  - England
TA  - Int Urogynecol J
JT  - International urogynecology journal
JID - 101567041
SB  - IM
MH  - Aged
MH  - Arteriovenous Anastomosis/*injuries
MH  - Female
MH  - Hematoma/*etiology
MH  - Humans
MH  - *Suburethral Slings
MH  - Urinary Incontinence, Stress/surgery
MH  - Urologic Surgical Procedures/*adverse effects
EDAT- 2011/01/19 06:00
MHDA- 2011/06/30 06:00
CRDT- 2011/01/19 06:00
PHST- 2010/10/28 00:00 [received]
PHST- 2010/12/16 00:00 [accepted]
PHST- 2011/01/19 06:00 [entrez]
PHST- 2011/01/19 06:00 [pubmed]
PHST- 2011/06/30 06:00 [medline]
AID - 10.1007/s00192-010-1355-2 [doi]
PST - ppublish
SO  - Int Urogynecol J. 2011 Apr;22(4):443-5. doi: 10.1007/s00192-010-1355-2. Epub 2011
      Jan 18.


PMID- 21243051
OWN - NLM
STAT- MEDLINE
DCOM- 20110509
LR  - 20211020
IS  - 1558-9439 (Electronic)
IS  - 1536-5050 (Linking)
VI  - 99
IP  - 1
DP  - 2011 Jan
TI  - Balancing between two goods: Health Insurance Portability and Accountability Act 
      and ethical compliancy considerations for privacy-sensitive materials in health
      sciences archival and historical special collections.
PG  - 15-22
LID - 10.3163/1536-5050.99.1.005 [doi]
AB  - OBJECTIVE: The investigation provides recommendations for establishing
      institutional collection guidelines and policies that protect the integrity of
      the historical record, while upholding the privacy and confidentiality of those
      who are protected by Health Insurance Portability and Accountability Act (HIPAA) 
      or professional ethical standards. METHODS: The authors completed a systematic
      historical investigation of the concepts of collection integrity, privacy, and
      confidentiality in the formal and informal legal and professional ethics
      literature and applied these standards to create best practices for institutional
      policies in these areas. RESULTS: Through an in-depth examination of the
      historical concepts of privacy and confidentiality in the legal and professional 
      ethics literature, the authors were able to create recommendations that would
      allow institutions to provide access to important, yet sensitive, materials,
      while complying with the standards set by HIPAA regulations and professional
      ethical expectations. CONCLUSION: With thoughtful planning, it is possible to
      balance the integrity of and access to the historical record of sensitive
      documents, while supporting the privacy protections of HIPAA and professional
      ethical standards. Although it is theorized that collection development policies 
      of institutions have changed due to HIPAA legislation, additional research is
      suggested to see how various legal interpretations have affected the integrity of
      the historical record in actuality.
FAU - Wiener, Judith A
AU  - Wiener JA
AD  - The Ohio State University, Columbus, OH 43210, USA. judith.wiener@osumc.edu
FAU - Gilliland, Anne T
AU  - Gilliland AT
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Med Libr Assoc
JT  - Journal of the Medical Library Association : JMLA
JID - 101132728
SB  - IM
MH  - *Guideline Adherence
MH  - *Health Insurance Portability and Accountability Act
MH  - Libraries, Medical/*ethics
MH  - Library Collection Development/*ethics
MH  - Privacy/*legislation & jurisprudence
MH  - United States
PMC - PMC3016646
EDAT- 2011/01/19 06:00
MHDA- 2011/05/10 06:00
CRDT- 2011/01/19 06:00
PHST- 2011/01/19 06:00 [entrez]
PHST- 2011/01/19 06:00 [pubmed]
PHST- 2011/05/10 06:00 [medline]
AID - 10.3163/1536-5050.99.1.005 [doi]
PST - ppublish
SO  - J Med Libr Assoc. 2011 Jan;99(1):15-22. doi: 10.3163/1536-5050.99.1.005.


PMID- 21242765
OWN - NLM
STAT- MEDLINE
DCOM- 20120221
LR  - 20211020
IS  - 1538-9804 (Electronic)
IS  - 0162-220X (Linking)
VI  - 34
IP  - 6
DP  - 2011 Nov-Dec
TI  - "I had already made up my mind": patients and caregivers' perspectives on making 
      the decision to participate in research at a US cancer referral center.
PG  - 428-33
LID - 10.1097/NCC.0b013e318207cb03 [doi]
AB  - BACKGROUND: Hematopoietic cell transplants (HCTs) are associated with high
      morbidity and mortality, which complicate the decision-making process for people 
      considering HCT clinical trials. There is a lack of research examining
      longitudinally how patients make clinical trial participation decisions in US
      cancer referral centers. OBJECTIVE: A qualitative study was conducted to examine 
      how patients and their family caregivers decide to participate in HCT research at
      a US cancer referral center. METHODS: Semistructured interviews were conducted
      with 25 patients enrolled in early-stage phase 2 HCT research studies and with 20
      family caregivers. Interviews were conducted before HCT and approximately days 80
      and 365 after HCT. RESULTS: Most patients (92%) and their caregivers (75%)
      decided to participate in research well before consent conferences at the cancer 
      referral center. Patients' reasons for deciding to participate included having
      "no other option," seeking a cure, and following their home oncologists'
      recommendations. CONCLUSION: Currently, US researchers are primarily guided by
      Federal regulations that view the decision-making process as a cognitive one.
      Findings confirmed cognition was a part of consent; however, most patients made
      the decision to participate in high-risk clinical trials long before they had
      been apprised of the specific information about the study and before the consent 
      conference. IMPLICATIONS FOR PRACTICE: The high risk of death from the disease
      and/or the HCT underscored the emotional component of decision making and
      affirmed that researchers need to acknowledge this emotional component to meet
      the ethical imperative of providing "informed consent."
FAU - Shannon-Dorcy, Kathleen
AU  - Shannon-Dorcy K
AD  - Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA.
      kshannon@fhcrc.org
FAU - Drevdahl, Denise J
AU  - Drevdahl DJ
LA  - eng
GR  - R21 NR008947-02/NR/NINR NIH HHS/United States
GR  - 1 R21 R21NR00947/NR/NINR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Cancer Nurs
JT  - Cancer nursing
JID - 7805358
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cancer Care Facilities
MH  - Caregivers/*psychology
MH  - *Clinical Trials as Topic
MH  - *Decision Making
MH  - Female
MH  - Follow-Up Studies
MH  - Hematologic Neoplasms/mortality/surgery
MH  - *Hematopoietic Stem Cell Transplantation/mortality
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Male
MH  - Middle Aged
MH  - Patient Participation/*psychology
MH  - Qualitative Research
MH  - Referral and Consultation
MH  - Risk Assessment
MH  - United States
MH  - Young Adult
PMC - PMC3134632
MID - NIHMS273136
EDAT- 2011/01/19 06:00
MHDA- 2012/02/22 06:00
CRDT- 2011/01/19 06:00
PHST- 2011/01/19 06:00 [entrez]
PHST- 2011/01/19 06:00 [pubmed]
PHST- 2012/02/22 06:00 [medline]
AID - 10.1097/NCC.0b013e318207cb03 [doi]
PST - ppublish
SO  - Cancer Nurs. 2011 Nov-Dec;34(6):428-33. doi: 10.1097/NCC.0b013e318207cb03.


PMID- 21242454
OWN - NLM
STAT- MEDLINE
DCOM- 20110223
LR  - 20110118
IS  - 1538-3644 (Electronic)
IS  - 0004-0010 (Linking)
VI  - 146
IP  - 1
DP  - 2011 Jan
TI  - Emerging trends in the outsourcing of medical and surgical care.
PG  - 107-12
LID - 10.1001/archsurg.2010.308 [doi]
AB  - As total health care expenditures are expected to constitute an increasing
      portion of the US gross domestic product during the coming years, the US health
      care system is anticipating a historic spike in the need for care. Outsourcing
      medical and surgical care to other nations has expanded rapidly, and several
      ethical, legal, and financial considerations require careful evaluation.
      Ultimately, the balance between cost savings, quality, and patient satisfaction
      will be the key determinant in the future of medical outsourcing.
FAU - Boyd, Jennifer B
AU  - Boyd JB
AD  - Department of Surgery, University of California, San Francisco, 94143-0790, USA.
FAU - McGrath, Mary H
AU  - McGrath MH
FAU - Maa, John
AU  - Maa J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Arch Surg
JT  - Archives of surgery (Chicago, Ill. : 1960)
JID - 9716528
SB  - IM
MH  - Cost Savings
MH  - *Developing Countries/economics
MH  - Health Care Costs
MH  - Health Expenditures/trends
MH  - Humans
MH  - India
MH  - Medical Tourism/economics/*trends
MH  - Medicare/economics
MH  - Outsourced Services/economics/trends
MH  - Quality of Health Care
MH  - Singapore
MH  - Surgical Procedures, Operative/economics/*trends
MH  - Thailand
MH  - United States
EDAT- 2011/01/19 06:00
MHDA- 2011/02/24 06:00
CRDT- 2011/01/19 06:00
PHST- 2011/01/19 06:00 [entrez]
PHST- 2011/01/19 06:00 [pubmed]
PHST- 2011/02/24 06:00 [medline]
AID - 146/1/107 [pii]
AID - 10.1001/archsurg.2010.308 [doi]
PST - ppublish
SO  - Arch Surg. 2011 Jan;146(1):107-12. doi: 10.1001/archsurg.2010.308.


PMID- 21242209
OWN - NLM
STAT- MEDLINE
DCOM- 20110207
LR  - 20181023
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 342
DP  - 2011 Jan 17
TI  - Ethics and effectiveness: rationing healthcare by thresholds of minimum
      effectiveness.
PG  - d54
LID - 10.1136/bmj.d54 [doi]
LID - bmj.d54 [pii]
FAU - Buyx, Alena M
AU  - Buyx AM
AD  - Institute for Ethics, History and Philosophy of Medicine, University Hospital
      Munster, Germany. abuyx@nuffieldbioethics.org
FAU - Friedrich, Daniel R
AU  - Friedrich DR
FAU - Schone-Seifert, Bettina
AU  - Schone-Seifert B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110117
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
SB  - IM
MH  - Comparative Effectiveness Research/ethics
MH  - Cost-Benefit Analysis/ethics
MH  - Health Care Rationing/economics/*ethics
MH  - Humans
MH  - Patient Satisfaction
MH  - Public Opinion
EDAT- 2011/01/19 06:00
MHDA- 2011/02/08 06:00
CRDT- 2011/01/19 06:00
PHST- 2011/01/19 06:00 [entrez]
PHST- 2011/01/19 06:00 [pubmed]
PHST- 2011/02/08 06:00 [medline]
AID - 10.1136/bmj.d54 [doi]
PST - epublish
SO  - BMJ. 2011 Jan 17;342:d54. doi: 10.1136/bmj.d54.


PMID- 21241480
OWN - NLM
STAT- MEDLINE
DCOM- 20110428
LR  - 20220311
IS  - 1756-9966 (Electronic)
IS  - 0392-9078 (Linking)
VI  - 30
DP  - 2011 Jan 17
TI  - Stem cells in clinical practice: applications and warnings.
PG  - 9
LID - 10.1186/1756-9966-30-9 [doi]
AB  - UNLABELLED: Stem cells are a relevant source of information about cellular
      differentiation, molecular processes and tissue homeostasis, but also one of the 
      most putative biological tools to treat degenerative diseases. This review
      focuses on human stem cells clinical and experimental applications. Our aim is to
      take a correct view of the available stem cell subtypes and their rational use in
      the medical area, with a specific focus on their therapeutic benefits and side
      effects. We have reviewed the main clinical trials dividing them basing on their 
      clinical applications, and taking into account the ethical issue associated with 
      the stem cell therapy. METHODS: We have searched Pubmed/Medline for clinical
      trials, involving the use of human stem cells, using the key words "stem cells"
      combined with the key words "transplantation", "pathology", "guidelines",
      "properties" and "risks". All the relevant clinical trials have been included.
      The results have been divided into different categories, basing on the way stem
      cells have been employed in different pathological conditions.
FAU - Lodi, Daniele
AU  - Lodi D
AD  - Department of Nephrology, Dialysis and Transplantation, University of Modena and 
      Reggio Emilia Medical School, Modena, Italy.
FAU - Iannitti, Tommaso
AU  - Iannitti T
FAU - Palmieri, Beniamino
AU  - Palmieri B
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110117
PL  - England
TA  - J Exp Clin Cancer Res
JT  - Journal of experimental & clinical cancer research : CR
JID - 8308647
SB  - IM
MH  - Animals
MH  - Autoimmune Diseases/therapy
MH  - Clinical Trials as Topic
MH  - Eye Diseases/therapy
MH  - Heart Failure/therapy
MH  - Humans
MH  - Liver Diseases/therapy
MH  - Medical Tourism/economics/ethics
MH  - Neoplasms/therapy
MH  - Nervous System Diseases/therapy
MH  - Practice Guidelines as Topic
MH  - Stem Cell Research/ethics
MH  - *Stem Cell Transplantation/adverse effects/ethics
MH  - *Stem Cells/cytology
PMC - PMC3033847
EDAT- 2011/01/19 06:00
MHDA- 2011/04/29 06:00
CRDT- 2011/01/19 06:00
PHST- 2010/10/26 00:00 [received]
PHST- 2011/01/17 00:00 [accepted]
PHST- 2011/01/19 06:00 [entrez]
PHST- 2011/01/19 06:00 [pubmed]
PHST- 2011/04/29 06:00 [medline]
AID - 1756-9966-30-9 [pii]
AID - 10.1186/1756-9966-30-9 [doi]
PST - epublish
SO  - J Exp Clin Cancer Res. 2011 Jan 17;30:9. doi: 10.1186/1756-9966-30-9.


PMID- 21241347
OWN - NLM
STAT- MEDLINE
DCOM- 20111220
LR  - 20220409
IS  - 1471-6712 (Electronic)
IS  - 0283-9318 (Linking)
VI  - 25
IP  - 3
DP  - 2011 Sep
TI  - Patients' perceptions of barriers for participation in nursing care.
PG  - 575-82
LID - 10.1111/j.1471-6712.2010.00866.x [doi]
AB  - BACKGROUND: In many Western countries as in Sweden, patients have legal right to 
      participate in own care individually adjusted to each patient's wishes and
      abilities. There are still few empirical studies of patients' perceptions of
      barriers for participation. Accordingly, there is a need to identify what may
      prevent patients from playing an active role in own nursing care. Such knowledge 
      is highly valuable for the nursing profession when it comes to implementation of 
      individual patient participation. AIM AND OBJECTIVE: To explore barriers for
      patient participation in nursing care with a special focus on adult patients with
      experience of inpatient physical care. METHODOLOGICAL DESIGN AND JUSTIFICATION:
      Data were collected through 6 focus groups with 26 Swedish informants recruited
      from physical inpatient care as well as discharged patients from such a setting. 
      A content analysis with qualitative approach of the tape-recorded interview
      material was made. ETHICAL ISSUES AND APPROVAL: The ethics of scientific work was
      adhered to. Each study participant gave informed consent after verbal and written
      information. The Ethics Committee of Goteborg University approved the study.
      RESULTS: The barriers for patient participation were identified as four
      categories: Facing own inability, meeting lack of empathy, meeting a
      paternalistic attitude and sensing structural barriers, and their 10 underlying
      subcategories. CONCLUSIONS: Our study contributes knowledge and understanding of 
      patients' experiences of barriers for participation. The findings point to
      remaining structures and nurse attitudes that are of disadvantage for patients'
      participation. The findings may increase the understanding of patient
      participation and may serve as an incentive in practice and nursing education to 
      meet and eliminate these barriers, in quality assurance of care, work
      organization and further research.
CI  - (c) 2011 The Authors. Scandinavian Journal of Caring Sciences (c) 2011 Nordic
      College of Caring Science.
FAU - Larsson, Inga E
AU  - Larsson IE
AD  - Department of Nursing, Health and Culture, University West, Trollhattan, Sweden. 
      inga-larsson@tele2.se
FAU - Sahlsten, Monika J M
AU  - Sahlsten MJ
FAU - Segesten, Kerstin
AU  - Segesten K
FAU - Plos, Kaety A E
AU  - Plos KA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110117
PL  - Sweden
TA  - Scand J Caring Sci
JT  - Scandinavian journal of caring sciences
JID - 8804206
MH  - Humans
MH  - *Nursing Care
MH  - *Patient Acceptance of Health Care
MH  - Patients/*psychology
MH  - Sweden
EDAT- 2011/01/19 06:00
MHDA- 2011/12/21 06:00
CRDT- 2011/01/19 06:00
PHST- 2011/01/19 06:00 [entrez]
PHST- 2011/01/19 06:00 [pubmed]
PHST- 2011/12/21 06:00 [medline]
AID - 10.1111/j.1471-6712.2010.00866.x [doi]
PST - ppublish
SO  - Scand J Caring Sci. 2011 Sep;25(3):575-82. doi: 10.1111/j.1471-6712.2010.00866.x.
      Epub 2011 Jan 17.


PMID- 21241346
OWN - NLM
STAT- MEDLINE
DCOM- 20121112
LR  - 20120613
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 26
IP  - 6
DP  - 2012 Jul
TI  - Continuous deep sedation at the end of life and the 'natural death' hypothesis.
PG  - 329-36
LID - 10.1111/j.1467-8519.2010.01861.x [doi]
AB  - Surveys in different countries (e.g. the UK, Belgium and The Netherlands) show a 
      marked recent increase in the incidence of continuous deep sedation at the end of
      life (CDS). Several hypotheses can be formulated to explain the increasing
      performance of this practice. In this paper we focus on what we call the 'natural
      death' hypothesis, i.e. the hypothesis that acceptance of CDS has spread rapidly 
      because death after CDS can be perceived as a 'natural' death by medical
      practitioners, patients' relatives and patients. We attempt to show that the
      label 'natural' cannot be unproblematically applied to the nature of this
      end-of-life practice. We argue that the labeling of death following CDS as
      'natural' death is related to a complex set of mechanisms which facilitate the
      use of this practice. However, our criticism does not preclude the view that CDS 
      may be clinically and ethically justified in many cases.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Raus, Kasper
AU  - Raus K
AD  - Ghent University, Department of Philosophy and Moral Sciences, Blandijnberg 2,
      9000 Ghent, Belgium. Kasper.Raus@UGent.be
FAU - Sterckx, Sigrid
AU  - Sterckx S
FAU - Mortier, Freddy
AU  - Mortier F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110117
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Attitude to Death
MH  - Decision Making/*ethics
MH  - Deep Sedation/*ethics
MH  - Ethical Theory
MH  - Humans
MH  - Palliative Care/*ethics
MH  - Terminal Care/*ethics
EDAT- 2011/01/19 06:00
MHDA- 2012/11/13 06:00
CRDT- 2011/01/19 06:00
PHST- 2011/01/19 06:00 [entrez]
PHST- 2011/01/19 06:00 [pubmed]
PHST- 2012/11/13 06:00 [medline]
AID - 10.1111/j.1467-8519.2010.01861.x [doi]
PST - ppublish
SO  - Bioethics. 2012 Jul;26(6):329-36. doi: 10.1111/j.1467-8519.2010.01861.x. Epub
      2011 Jan 17.


PMID- 21241345
OWN - NLM
STAT- MEDLINE
DCOM- 20121112
LR  - 20120613
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 26
IP  - 6
DP  - 2012 Jul
TI  - Expertise, wisdom and moral philosophers: a response to Gesang.
PG  - 337-42
LID - 10.1111/j.1467-8519.2010.01860.x [doi]
AB  - In a recent issue of Bioethics, Bernard Gesang asks whether a moral philosopher
      possesses greater moral expertise than a non-philosopher, and his answer is a
      qualified yes, based not so much on his infallible access to the truth, but on
      the quality of his theoretically-informed moral justifications. I reject Gesang's
      claim that there is such a thing as moral expertise, although the moral
      philosopher may well make a valid contribution to the ethics committee as a
      concerned and educated citizen. I suggest that wisdom is a lot more interesting
      to examine than moral expertise. Again, however, moral philosophers have no
      monopoly on wisdom, and the study of philosophy may even impede its cultivation.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Cowley, Christopher
AU  - Cowley C
AD  - School of Philosophy in University College Dublin, Dublin 4, Ireland.
      Christopher.cowley@ucd.ie
LA  - eng
PT  - Journal Article
DEP - 20110117
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - *Ethicists
MH  - Ethics Committees
MH  - Euthanasia/ethics
MH  - Humans
MH  - Judgment
MH  - *Professional Competence
MH  - *Professional Role
MH  - Social Responsibility
MH  - Stem Cell Research/ethics
EDAT- 2011/01/19 06:00
MHDA- 2012/11/13 06:00
CRDT- 2011/01/19 06:00
PHST- 2011/01/19 06:00 [entrez]
PHST- 2011/01/19 06:00 [pubmed]
PHST- 2012/11/13 06:00 [medline]
AID - 10.1111/j.1467-8519.2010.01860.x [doi]
PST - ppublish
SO  - Bioethics. 2012 Jul;26(6):337-42. doi: 10.1111/j.1467-8519.2010.01860.x. Epub
      2011 Jan 17.


PMID- 21241344
OWN - NLM
STAT- MEDLINE
DCOM- 20121112
LR  - 20141120
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 26
IP  - 6
DP  - 2012 Jul
TI  - Realizing benefit sharing - the case of post-study obligations.
PG  - 305-14
LID - 10.1111/j.1467-8519.2010.01857.x [doi]
AB  - In 2006, the Indonesian government decided to withhold avian flu samples from the
      World Health Organization. They argued that even though Indonesian samples were
      crucial to the development of vaccines, the results of vaccine research would be 
      unaffordable for its citizens. Commentaries on the case varied from alleging
      blackmail to welcoming this strong stance against alleged exploitation. What is
      clear is that the concern expressed is related to benefit sharing. Benefit
      sharing requires resource users to return benefits to resource providers in order
      to achieve justice. One benefit sharing tool within health research is the duty
      to provide a health care intervention which has been proven to be beneficial (or 
      alternative benefits) to research participants after a study has been concluded. 
      This duty is generally known as a post-study obligation. It was enshrined in the 
      Declaration of Helsinki in 2000 and re-emphasized in 2008. Yet, there are few, if
      any, examples of good practice. In this article, we analyse the obstacles to
      giving more bite to benefit sharing provisions in health research through ethical
      review. We conclude that the provision of post-study access to healthcare
      interventions is not a promising mechanism when monitored through research ethics
      committees. Alternative benefit provision is preferable if one focuses on
      achieving compliance. However, even the latter faces challenges, which we address
      in specific recommendations.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Schroeder, Doris
AU  - Schroeder D
AD  - University of Central Lancashire, Centre for Professional Ethics, Brook 317,
      Preston PR1 2HE, United Kingdom. dschroeder@uclan.ac.uk
FAU - Gefenas, Eugenijus
AU  - Gefenas E
LA  - eng
PT  - Journal Article
DEP - 20110117
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
CIN - Bioethics. 2012 Sep;26(7):393-4. PMID: 22150112
MH  - *Beneficence
MH  - Biological Specimen Banks/ethics
MH  - Developing Countries
MH  - Genetic Research/ethics
MH  - Global Health
MH  - Helsinki Declaration
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Information Dissemination/ethics
MH  - *International Cooperation
MH  - *Moral Obligations
EDAT- 2011/01/19 06:00
MHDA- 2012/11/13 06:00
CRDT- 2011/01/19 06:00
PHST- 2011/01/19 06:00 [entrez]
PHST- 2011/01/19 06:00 [pubmed]
PHST- 2012/11/13 06:00 [medline]
AID - 10.1111/j.1467-8519.2010.01857.x [doi]
PST - ppublish
SO  - Bioethics. 2012 Jul;26(6):305-14. doi: 10.1111/j.1467-8519.2010.01857.x. Epub
      2011 Jan 17.


PMID- 21241343
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20211203
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 26
IP  - 5
DP  - 2012 Jun
TI  - Ethics, ambiguity aversion, and the review of complex translational clinical
      trials.
PG  - 242-50
LID - 10.1111/j.1467-8519.2010.01856.x [doi]
AB  - Clinical trials of novel agents often present several layers of ethical
      challenge. Because time and resources for ethical and safety review are limited, 
      how investigators, IRBs, and regulators allocate attention to a trial's various
      safety dimensions itself represents a critical ethical question. In what follows,
      I use the example of a Parkinson's disease gene transfer trial to show how risks 
      involving unknown probabilities or outcomes (ambiguity), might sometimes draw
      attention away from risks that involve known probabilities or outcomes. This
      potentially undermines the goal of 'systematic and nonarbitrary analysis of risk'
      during ethical review. To counteract the possible effects of such attention
      biases, I propose that reviewers develop 'cognitive aids' like lists and, where
      appropriate, set aside time to discuss non-ambiguous risks. I also propose
      further research for addressing and understanding how attention allocation,
      emotion, and ambiguity influence ethical decision-making.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Kimmelman, Jonathan
AU  - Kimmelman J
AD  - McGill University, Montreal, QB H3A 1X1, Canada. jonathan.kimmelman@mcgill.ca
LA  - eng
GR  - MOP 77670/Canadian Institutes of Health Research/Canada
GR  - NNF 80045/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110117
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Attention
MH  - Bias
MH  - Clinical Trials, Phase I as Topic/*ethics
MH  - *Ethical Review
MH  - Gene Transfer Techniques/ethics
MH  - Genetic Therapy/ethics
MH  - Humans
MH  - Parkinson Disease/therapy
MH  - Risk Assessment/methods
MH  - *Risk Management/ethics/methods
MH  - Translational Research, Biomedical/*ethics
MH  - Uncertainty
EDAT- 2011/01/19 06:00
MHDA- 2012/09/21 06:00
CRDT- 2011/01/19 06:00
PHST- 2011/01/19 06:00 [entrez]
PHST- 2011/01/19 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
AID - 10.1111/j.1467-8519.2010.01856.x [doi]
PST - ppublish
SO  - Bioethics. 2012 Jun;26(5):242-50. doi: 10.1111/j.1467-8519.2010.01856.x. Epub
      2011 Jan 17.


PMID- 21205681
OWN - NLM
STAT- MEDLINE
DCOM- 20110127
LR  - 20151119
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Linking)
VI  - 76
IP  - 1 Suppl 1
DP  - 2011 Jan 4
TI  - Improving long-term follow-up studies of immunomodulatory therapies.
PG  - S35-8
LID - 10.1212/WNL.0b013e3182050599 [doi]
AB  - Goals in the treatment of multiple sclerosis (MS) focus on reducing symptoms and 
      disease progression. Registry data indicate that the accumulation of significant 
      disability can take decades. Therefore, long-term follow-up (LTFU) studies are
      needed to understand the impact of disease-modifying therapy (DMT) in MS. Based
      on analyses of available LTFU study data, recommendations for future LTFU studies
      can be made. A disability milestone may be considered because exploratory data
      show that DMT may slow the progression of disability. Achievement of the EDSS
      steps 4 or 6 may be sufficient milestones because, once reached, MS progresses
      inevitably. Since a placebo control cannot be ethically used in LTFU studies, a
      standard-of-care comparator could be considered. The ideal LTFU study should be
      performed according to the highest possible standards. A high-quality LTFU study 
      would achieve high retention rates, capture complete data at prespecified
      assessment intervals, and be powered to the key outcome measure. In addition,
      propensity scoring is an approach used to reduce bias in treatment comparisons in
      observational studies and might be a suitable approach for analyzing LTFU
      studies. With careful consideration of LTFU limitations and study design, it is
      possible to attain a high degree of rigor in future studies.
FAU - Freedman, Mark S
AU  - Freedman MS
AD  - University of Ottawa, Ottawa, Ontario, Canada. mfreedman@ottawahospital.on.ca
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - 0 (Immunologic Factors)
RN  - 145155-23-3 (Interferon beta-1b)
RN  - 77238-31-4 (Interferon-beta)
RN  - XRO4566Q4R (Interferon beta-1a)
SB  - IM
MH  - Follow-Up Studies
MH  - Humans
MH  - Immunologic Factors/*therapeutic use
MH  - Immunomodulation
MH  - Interferon beta-1a
MH  - Interferon beta-1b
MH  - Interferon-beta/*therapeutic use
MH  - Multiple Sclerosis/immunology/*therapy
MH  - Quality of Life
MH  - Time Factors
EDAT- 2011/01/19 06:00
MHDA- 2011/01/29 06:00
CRDT- 2011/01/06 06:00
PHST- 2011/01/06 06:00 [entrez]
PHST- 2011/01/19 06:00 [pubmed]
PHST- 2011/01/29 06:00 [medline]
AID - 76/1_Supplement_1/S35 [pii]
AID - 10.1212/WNL.0b013e3182050599 [doi]
PST - ppublish
SO  - Neurology. 2011 Jan 4;76(1 Suppl 1):S35-8. doi: 10.1212/WNL.0b013e3182050599.


PMID- 21240856
OWN - NLM
STAT- MEDLINE
DCOM- 20110325
LR  - 20181201
IS  - 1828-1427 (Electronic)
IS  - 0505-401X (Linking)
VI  - 47
IP  - 1
DP  - 2011 Jan-Mar
TI  - In memoriam: Jean Blancou, DVM, 1936-2010. World authority on rabies, historian
      and former Director General of the World Organisation for Animal Health (Office
      International des Epizooties: OIE).
PG  - 105-6
AB  - Jean-Marie Blancou was born in Bangui on 28 August 1936 and passed away in Paris 
      on 10 November 2010 at the age of 74. After studying at the Pierre de Fermat
      Lycee in Toulouse, Jean Blancou graduated from the Toulouse Veterinary School in 
      1960. He continued his studies in tropical veterinary medicine in Paris until
      1963, extending his knowledge of immunology, microbiology, biochemistry and
      zoology, at the Institut Pasteur. He obtained his doctorate in biological
      sciences at the University of Nancy in 1982. Jean Blancou commenced his career as
      technical adviser to the Veterinary Services of Ethiopia where he directed a
      campaign against rinderpest in the south of the county. From 1965 to 1967 he was 
      deputy director of the national veterinary laboratory in Niamey where he was
      responsible for the diagnosis of animal diseases and the production of veterinary
      vaccines. In 1967, he moved to the central livestock laboratory in Madagascar,
      where he commenced research on the diagnosis and control of dermatophilosis,
      bovine tuberculosis and other bacterial and parasitic diseases. In August 1968 he
      married Genevieve Orue. In 1975 he was appointed as head of the national
      veterinary laboratory in Senegal, where he remained until 1977. Initially deputy 
      director, and then director of Research on rabies and wildlife diseases, at the
      World Health Organization collaborating centre in Nancy, he remained in this
      position until 1990. Jean Blancou was recognised as a world authority on rabies. 
      He conducted research into the diagnosis, aetiology, epidemiology and control of 
      rabies during his time in Nancy. Between 1988 and 1990, Dr Blancou also headed
      the animal health and protection department of the Centre national d'etudes
      veterinaires et animales (CNEVA) in Maisons-Alfort. On 1 January 1991, he was
      appointed director general of the World Organisation for Animal Health (Office
      International des Epizooties: OIE) and was re-elected in 1995 for a further
      five-year term, until he retired in 2000. He attached great importance to the
      value of scientific publication and to the ethics involved in producing
      scientific literature. He had a very strong interest in the historical aspects of
      animal diseases and, in 2003, published a valuable book entitled History of the
      surveillance and control of transmissible animal diseases. He would always ensure
      that the most interesting and appropriate historic illustrations, irrespective of
      how difficult they were to obtain, were selected for the papers he published.
      Among some of the activities Jean Blancou undertook during his retirement was the
      mammoth task of co-editing Infectious and parasitic diseases of livestock in
      French and English. Dr Blancou authored over 370 scientific publications devoted 
      to animal diseases, to the production and control of biologicals and, of course, 
      many authoritative articles on rabies and vaccinology. He was always generous
      with the scientific knowledge he possessed and never missed an opportunity to
      assist colleagues in the preparation or correction of manuscripts that they
      wished to submit to peer-reviewed journals. He was gentle in nature and always
      softly spoken. As one of his colleagues wrote: 'we have lost a most gentle,
      thoughtful and kind man and the world has lost one of its stellar veterinarians'.
      Despite his busy and brilliant career, Jean Blancou was a family man and devoted 
      to the education of his children. During his illness, he showed great courage.
      The Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise 'G. Caporale'
      has been privileged to benefit from the expert knowledge and experience that Dr
      Blancou so generously provided in his capacity as Member of the Scientific
      Advisory Board of Veterinaria Italiana. Jean Blancou is survived by his wife,
      Genevieve, his children and grandchildren.
LA  - eng
PT  - Biography
PT  - Historical Article
PT  - Journal Article
PT  - Portrait
PL  - Italy
TA  - Vet Ital
JT  - Veterinaria italiana
JID - 0201543
SB  - IM
MH  - Central African Republic
MH  - History
MH  - History, 20th Century
MH  - History, 21st Century
MH  - International Agencies
MH  - Rabies
MH  - Veterinary Medicine/*history
PS  - Blancou J
FPS - Blancou, Jean
EDAT- 2011/01/18 06:00
MHDA- 2011/03/26 06:00
CRDT- 2011/01/18 06:00
PHST- 2011/01/18 06:00 [entrez]
PHST- 2011/01/18 06:00 [pubmed]
PHST- 2011/03/26 06:00 [medline]
PST - ppublish
SO  - Vet Ital. 2011 Jan-Mar;47(1):105-6.


PMID- 21240804
OWN - NLM
STAT- MEDLINE
DCOM- 20110309
LR  - 20110117
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 11
IP  - 1
DP  - 2011 Jan
TI  - It is time to move beyond a culture of unexamined assumptions, recrimination, and
      blame to one of systematic analysis and ethical dialogue.
PG  - 31-3
LID - 10.1080/15265161.2011.534954 [doi]
FAU - Komesaroff, Paul
AU  - Komesaroff P
AD  - Monash University, Australia.
FAU - Kerridge, Ian
AU  - Kerridge I
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2011 Jan;11(1):23-8. PMID: 21240802
MH  - Clinical Trials as Topic/ethics
MH  - Concept Formation
MH  - *Conflict of Interest
MH  - *Drug Industry
MH  - *Ethics, Medical
MH  - Guidelines as Topic
MH  - Humans
MH  - *Patient Advocacy/ethics/standards
EDAT- 2011/01/18 06:00
MHDA- 2011/03/10 06:00
CRDT- 2011/01/18 06:00
PHST- 2011/01/18 06:00 [entrez]
PHST- 2011/01/18 06:00 [pubmed]
PHST- 2011/03/10 06:00 [medline]
AID - 932376087 [pii]
AID - 10.1080/15265161.2011.534954 [doi]
PST - ppublish
SO  - Am J Bioeth. 2011 Jan;11(1):31-3. doi: 10.1080/15265161.2011.534954.


PMID- 21240802
OWN - NLM
STAT- MEDLINE
DCOM- 20110309
LR  - 20111007
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 11
IP  - 1
DP  - 2011 Jan
TI  - Clarifying conflict of interest.
PG  - 23-8
LID - 10.1080/15265161.2011.568587 [doi]
AB  - As the debate over how to manage or discourage physicians' financial conflicts of
      interest with the drug and medical device industries has become more heated,
      critics have questioned or dismissed the concept of "conflict of interest"
      itself. A satisfactory definition relates conflict of interest to concerns about 
      maintaining social trust and distinguishes between breaches of ethical duty and
      temptations to breach duty. Numerous objections to such a definition have been
      offered, none of which prevails on further analysis. Those concerned about
      conflicts of interest have contributed to misunderstandings, however, by failing 
      to demonstrate when social arrangements leading to temptations to breach duties
      are in themselves morally blameworthy. Clarifying "conflict of interest" is
      important if we are eventually going to develop productive modes of engagement
      between medicine and for-profit industry that avoid the serious ethical pitfalls 
      now in evidence.
FAU - Brody, Howard
AU  - Brody H
AD  - University of Texas Medical Branch, Institute for the Medical Humanities,
      Galveston, TX 77555-1311, USA. habrody@utmb.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CIN - Am J Bioeth. 2011 Jan;11(1):1-2. PMID: 21240793
CIN - Am J Bioeth. 2011 Jan;11(1):W4-5. PMID: 21240796
CIN - Am J Bioeth. 2011 Jan;11(1):29-30. PMID: 21240803
CIN - Am J Bioeth. 2011 Jan;11(1):31-3. PMID: 21240804
CIN - Am J Bioeth. 2011 Jan;11(1):33-4. PMID: 21240805
CIN - Am J Bioeth. 2011 Jan;11(1):35-7. PMID: 21240806
CIN - Am J Bioeth. 2011 Jan;11(1):37-9. PMID: 21240807
CIN - Am J Bioeth. 2011 Jan;11(1):39-40. PMID: 21240808
CIN - Am J Bioeth. 2011 Jan;11(1):40-1. PMID: 21240809
CIN - Am J Bioeth. 2011 Jan;11(1):42-4. PMID: 21240810
CIN - Am J Bioeth. 2011 Jan;11(1):44-6. PMID: 21240811
CIN - Am J Bioeth. 2011 Jan;11(1):47-9. PMID: 21240812
CIN - Am J Bioeth. 2011 Jan;11(1):49-50. PMID: 21240813
CIN - Am J Bioeth. 2011 Jan;11(1):51-2. PMID: 21240814
CIN - Am J Bioeth. 2011 Sep;11(9):12-3. PMID: 21877964
MH  - *Biotechnology
MH  - Clinical Trials as Topic/ethics
MH  - *Conflict of Interest
MH  - *Drug Industry
MH  - Humans
MH  - Interprofessional Relations/*ethics
MH  - Patient Advocacy
MH  - Patient Education as Topic
MH  - Physicians/*ethics
MH  - Physicians, Family/ethics
MH  - *Private Sector/economics/ethics
MH  - Public Opinion
MH  - Research Support as Topic/ethics
MH  - Societies, Medical/ethics
MH  - Teaching Materials
MH  - Trust
MH  - United States
EDAT- 2011/01/18 06:00
MHDA- 2011/03/10 06:00
CRDT- 2011/01/18 06:00
PHST- 2011/01/18 06:00 [entrez]
PHST- 2011/01/18 06:00 [pubmed]
PHST- 2011/03/10 06:00 [medline]
AID - 932377397 [pii]
AID - 10.1080/15265161.2011.568587 [doi]
PST - ppublish
SO  - Am J Bioeth. 2011 Jan;11(1):23-8. doi: 10.1080/15265161.2011.568587.


PMID- 21240801
OWN - NLM
STAT- MEDLINE
DCOM- 20110309
LR  - 20110117
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 11
IP  - 1
DP  - 2011 Jan
TI  - Medical and genetic enhancements: ethical issues that will not go away.
PG  - 21-2
LID - 10.1080/15265161.2011.566671 [doi]
FAU - Wasson, Katherine
AU  - Wasson K
AD  - Loyola University Chicago, Neiswanger Institute for Bioethics & Health Policy,
      Maywood, IL 60153, USA. kawasson@lumc.edu
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2011 Jan;11(1):3-13. PMID: 21240795
MH  - *Attitude of Health Personnel
MH  - Biomedical Enhancement/ethics
MH  - Genetic Enhancement/*ethics
MH  - Genetic Testing
MH  - Humans
MH  - *Personal Autonomy
MH  - Physicians/standards/statistics & numerical data
MH  - *Social Justice
MH  - Socioeconomic Factors
MH  - Stress, Psychological/*prevention & control
EDAT- 2011/01/18 06:00
MHDA- 2011/03/10 06:00
CRDT- 2011/01/18 06:00
PHST- 2011/01/18 06:00 [entrez]
PHST- 2011/01/18 06:00 [pubmed]
PHST- 2011/03/10 06:00 [medline]
AID - 932379779 [pii]
AID - 10.1080/15265161.2011.566671 [doi]
PST - ppublish
SO  - Am J Bioeth. 2011 Jan;11(1):21-2. doi: 10.1080/15265161.2011.566671.


PMID- 21240608
OWN - NLM
STAT- MEDLINE
DCOM- 20110809
LR  - 20211020
IS  - 1432-1084 (Electronic)
IS  - 0938-7994 (Linking)
VI  - 21
IP  - 5
DP  - 2011 May
TI  - The breast lesion excision system (BLES): a novel technique in the diagnostic and
      therapeutic management of small indeterminate breast lesions?
PG  - 919-24
LID - 10.1007/s00330-010-2000-7 [doi]
AB  - OBJECTIVE: To investigate whether the breast lesion excision system (BLES) could 
      render formal surgery unnecessary in patients with small indeterminate breast
      lesions. METHODS: Following review board ethical permission and the consent of
      each patient, we aimed to perform a complete excision biopsy, with a margin, of
      small indeterminate breast lesions that measure less than 1 cm. 76 patients with 
      small BIRADS type 3 breast lesions underwent a BLES biopsy. Mean radiological
      lesion size was 7.1 mm (range 2-10 mm). RESULTS: 61 lesions had a final benign
      diagnosis, 6 of which underwent subsequent surgery although only 1 showing
      residual lesion. 15 lesions were malignant but with residual tumour at
      re-excision present in only 5 cases. CONCLUSION: The BLES biopsy is an
      efficacious technique at excising small indeterminate breast lesions with a
      complete margin without the need for follow-up diagnostic surgery in the
      majority.
FAU - Allen, Steven D
AU  - Allen SD
AD  - Department of Radiology, The Royal Marsden Hospital, Downs Road, Sutton, Surrey
      SM2 5PT, UK. steven.allen@rmh.nhs.net
FAU - Nerurkar, Ashish
AU  - Nerurkar A
FAU - Della Rovere, Guidabaldo U Querci
AU  - Della Rovere GU
LA  - eng
PT  - Journal Article
DEP - 20110115
PL  - Germany
TA  - Eur Radiol
JT  - European radiology
JID - 9114774
SB  - IM
MH  - Biopsy/*instrumentation/*methods
MH  - Biopsy, Needle/methods
MH  - Breast/pathology/surgery
MH  - Breast Diseases/*diagnosis/*surgery
MH  - Breast Neoplasms/diagnosis/surgery
MH  - Cicatrix/prevention & control
MH  - Equipment Design
MH  - Female
MH  - Fibroadenoma/diagnosis/surgery
MH  - Humans
MH  - Middle Aged
EDAT- 2011/01/18 06:00
MHDA- 2011/08/10 06:00
CRDT- 2011/01/18 06:00
PHST- 2010/05/19 00:00 [received]
PHST- 2010/10/08 00:00 [accepted]
PHST- 2010/09/29 00:00 [revised]
PHST- 2011/01/18 06:00 [entrez]
PHST- 2011/01/18 06:00 [pubmed]
PHST- 2011/08/10 06:00 [medline]
AID - 10.1007/s00330-010-2000-7 [doi]
PST - ppublish
SO  - Eur Radiol. 2011 May;21(5):919-24. doi: 10.1007/s00330-010-2000-7. Epub 2011 Jan 
      15.


PMID- 21239479
OWN - NLM
STAT- MEDLINE
DCOM- 20110506
LR  - 20110308
IS  - 1651-1905 (Electronic)
IS  - 1403-4948 (Linking)
VI  - 39
IP  - 2
DP  - 2011 Mar
TI  - Incentivizing deceased organ donation: a Swedish priority-setting perspective.
PG  - 156-63
LID - 10.1177/1403494810391522 [doi]
AB  - AIMS: The established deceased organ donation models in many countries, relying
      chiefly on altruism, have failed to motivate a sufficient number of donors. As a 
      consequence organs that could save lives are routinely missed leading to a
      growing gap between demand and supply. The aim of this paper is twofold; firstly 
      to develop a proposal for compensated deceased organ donation that could
      potentially address the organ shortage; secondly to examine the compatibility of 
      the proposal with the ethical values of the Swedish healthcare system. METHODS:
      The proposal for compensating deceased donation is grounded in behavioural agency
      theory and combines extrinsic, intrinsic and signalling incentives in order to
      increase prosocial behaviour. Furthermore the compatibility of our proposal with 
      the values of the Swedish healthcare system is evaluated in reference to the
      principles of human dignity, needs and solidarity, and cost effectiveness.
      RESULTS: Extrinsic incentives in the form of a 5,000 compensation towards funeral
      expenses paid to the estate of the deceased or family is proposed. Intrinsic and 
      signalling incentives are incorporated by allowing all or part of the
      compensation to be diverted as a donation to a reputable charity. The decision
      for organ donation must not be against the explicit will of the donor.
      CONCLUSIONS: We find that our proposal for compensated deceased donation is
      compatible with the values of the Swedish healthcare system, and therefore merits
      serious consideration. It is however important to acknowledge issues relating to 
      coercion, commodification and loss of public trust and the ethical challenges
      that they might pose.
FAU - Omar, Faisal
AU  - Omar F
AD  - Department of Medical and Health Sciences, Linkoping University, Linkoping,
      Sweden. faisal.omar@liu.se
FAU - Tinghog, Gustav
AU  - Tinghog G
FAU - Welin, Stellan
AU  - Welin S
LA  - eng
PT  - Journal Article
DEP - 20110114
PL  - Sweden
TA  - Scand J Public Health
JT  - Scandinavian journal of public health
JID - 100883503
SB  - IM
MH  - Commerce/ethics
MH  - Compensation and Redress/ethics
MH  - Cost-Benefit Analysis
MH  - Humans
MH  - *Motivation
MH  - Organ Transplantation/*economics/ethics
MH  - Sweden
MH  - Tissue and Organ Procurement/*economics/ethics
EDAT- 2011/01/18 06:00
MHDA- 2011/05/07 06:00
CRDT- 2011/01/18 06:00
PHST- 2011/01/18 06:00 [entrez]
PHST- 2011/01/18 06:00 [pubmed]
PHST- 2011/05/07 06:00 [medline]
AID - 1403494810391522 [pii]
AID - 10.1177/1403494810391522 [doi]
PST - ppublish
SO  - Scand J Public Health. 2011 Mar;39(2):156-63. doi: 10.1177/1403494810391522. Epub
      2011 Jan 14.


PMID- 21239017
OWN - NLM
STAT- MEDLINE
DCOM- 20110330
LR  - 20131121
IS  - 1527-3792 (Electronic)
IS  - 0022-5347 (Linking)
VI  - 185
IP  - 3
DP  - 2011 Mar
TI  - Efficacy of a second line luteinizing hormone-releasing hormone agonist after
      advanced prostate cancer biochemical recurrence.
PG  - 848-54
LID - 10.1016/j.juro.2010.10.055 [doi]
AB  - PURPOSE: Men with castrate resistant prostate cancer have limited treatment
      options. Although luteinizing hormone-releasing hormone agonists are in the same 
      class, they are slightly different in their pharmacology. We determined whether
      rechallenging patients with prostate cancer, who were receiving a luteinizing
      hormone-releasing hormone analogue but had progression, with a different
      luteinizing hormone-releasing hormone analogue (goserelin or leuprolide acetate) 
      would result in a prostate specific antigen response. Secondary objectives were
      to calculate the PSA response and determine whether sequence order impacted the
      response. MATERIALS AND METHODS: We performed a retrospective, ethics approved
      review of the records of patients with prostate cancer at multiple institutions
      who received a luteinizing hormone-releasing hormone analogue (goserelin or
      leuprolide acetate), experienced progression, as measured by 2 consecutive
      prostate specific antigen increases, and were rechallenged with the other
      analogue (goserelin or leuprolide acetate). Prostate specific antigen and
      relevant clinical data were obtained and statistical analysis was done. RESULTS: 
      Of 39 available men 27 (69%) had decreased prostate specific antigen after 3
      months of switching regimens. The median change in prostate specific antigen was 
      -1.5 (IQR -10.0, 0.8), indicating a statistically significant decrease (p=0.01). 
      The median percent prostate specific antigen change for leuprolide acetate to
      goserelin was -69.3% (IQR -81.5, 26.2) and for goserelin to leuprolide acetate it
      was -6.4% (IQR -61.7, 21.8, p=0.05). Median time to a subsequent prostate
      specific antigen increase was 5.2 months (95% CI 3.5-17.4). CONCLUSIONS: Prostate
      specific antigen decreased after switching luteinizing hormone-releasing hormone 
      therapies. This decrease appeared most significant in the group that switched
      from leuprolide acetate to goserelin. The duration of response after switching
      was approximately 5 months. The study is limited by its retrospective nature but 
      should encourage prospective evaluation of this observation.
CI  - Copyright (c) 2011 American Urological Association Education and Research, Inc.
      Published by Elsevier Inc. All rights reserved.
FAU - Lawrentschuk, Nathan
AU  - Lawrentschuk N
AD  - University of Toronto, University Health Network, Department of Urology, Princess
      Margaret Hospital, Toronto, Ontario, Canada. lawrentschuk@gmail.com
FAU - Fernandes, Kimberly
AU  - Fernandes K
FAU - Bell, David
AU  - Bell D
FAU - Barkin, Jack
AU  - Barkin J
FAU - Fleshner, Neil
AU  - Fleshner N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110115
PL  - United States
TA  - J Urol
JT  - The Journal of urology
JID - 0376374
RN  - 0F65R8P09N (Goserelin)
RN  - 33515-09-2 (Gonadotropin-Releasing Hormone)
RN  - EC 3.4.21.77 (Prostate-Specific Antigen)
RN  - EFY6W0M8TG (Leuprolide)
SB  - IM
CIN - J Urol. 2011 Mar;185(3):854; author reply 854. PMID: 21239016
MH  - Aged
MH  - Aged, 80 and over
MH  - Disease Progression
MH  - Gonadotropin-Releasing Hormone/*agonists
MH  - Goserelin/*therapeutic use
MH  - Humans
MH  - Leuprolide/*therapeutic use
MH  - Male
MH  - Neoplasm Recurrence, Local/blood/*drug therapy
MH  - Prostate-Specific Antigen/blood
MH  - Prostatic Neoplasms/blood/*drug therapy
MH  - Retrospective Studies
EDAT- 2011/01/18 06:00
MHDA- 2011/03/31 06:00
CRDT- 2011/01/18 06:00
PHST- 2010/06/23 00:00 [received]
PHST- 2011/01/18 06:00 [entrez]
PHST- 2011/01/18 06:00 [pubmed]
PHST- 2011/03/31 06:00 [medline]
AID - S0022-5347(10)04934-7 [pii]
AID - 10.1016/j.juro.2010.10.055 [doi]
PST - ppublish
SO  - J Urol. 2011 Mar;185(3):848-54. doi: 10.1016/j.juro.2010.10.055. Epub 2011 Jan
      15.


PMID- 21238657
OWN - NLM
STAT- MEDLINE
DCOM- 20110627
LR  - 20110117
IS  - 1531-5037 (Electronic)
IS  - 0022-3468 (Linking)
VI  - 46
IP  - 1
DP  - 2011 Jan
TI  - Elements of successful intestinal rehabilitation.
PG  - 150-6
LID - 10.1016/j.jpedsurg.2010.09.083 [doi]
AB  - PURPOSE: The optimal therapy for intestinal failure (IF) is unknown. The results 
      of a systematic, protocol-driven management strategy by a multidisciplinary team 
      are described. METHODS: Intestinal failure was defined as bowel length of less
      than 40 cm or parenteral nutrition (PN) for more than 42 days. A
      multidisciplinary team and protocol to prevent PN-associated liver disease
      (PNALD) were instituted in 2006. Data were gathered prospectively with consent
      and ethics board approval. RESULTS: From 1998 to 2006, 33 patients were treated
      (historical cohort) with an overall survival of 72%. Rotating prophylactic
      antibiotics for bacterial overgrowth were given to 27% of patients; 6% had
      lipid-sparing PN, and none received fish oil-based lipids. Median time to
      intestinal rehabilitation was 7 +/- 3.1 months, and 27% of patients who developed
      PNALD died. From 2006 to 2009, 31 patients were treated. Seventy-seven percent
      received PAB; 60%, lipid-sparing PN; and 47%, parenteral fish oil emulsion.
      Eighty-seven percent weaned from PN at 3.9 +/- 3.8 months, and no patients
      developed PNALD with 100% survival. Novel lipid therapies were associated with
      changes in essential fatty acid profile and one case of clinical essential fatty 
      acid deficiency. CONCLUSION: The institution of a multidisciplinary team and a
      protocol-driven strategy to prevent PNALD improves survival in IF. Further
      studies are recommended.
CI  - Copyright A(c) 2011 Elsevier Inc. All rights reserved.
FAU - Sigalet, David
AU  - Sigalet D
AD  - Division of Pediatric General Surgery, Alberta Children's Hospital, University of
      Calgary, Calgary, Canada. sigalet@ucalgary.ca
FAU - Boctor, Dana
AU  - Boctor D
FAU - Brindle, Mary
AU  - Brindle M
FAU - Lam, Viona
AU  - Lam V
FAU - Robertson, Marli
AU  - Robertson M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Pediatr Surg
JT  - Journal of pediatric surgery
JID - 0052631
RN  - 0 (Emulsions)
RN  - 0 (Fat Emulsions, Intravenous)
RN  - 0 (Fatty Acids, Omega-3)
RN  - 0 (Fish Oils)
RN  - 0 (Phospholipids)
RN  - 0 (soybean oil, phospholipid emulsion)
RN  - 8001-22-7 (Soybean Oil)
SB  - IM
MH  - Antibiotic Prophylaxis/methods
MH  - Cholestasis/etiology/prevention & control
MH  - Clinical Protocols
MH  - Cohort Studies
MH  - Digestive System Surgical Procedures/methods
MH  - Emulsions/therapeutic use
MH  - Fat Emulsions, Intravenous/therapeutic use
MH  - Fatty Acids, Omega-3/therapeutic use
MH  - Fish Oils/therapeutic use
MH  - Follow-Up Studies
MH  - Gastroschisis/surgery
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Liver Diseases/etiology/prevention & control
MH  - Longitudinal Studies
MH  - Parenteral Nutrition/*adverse effects
MH  - Patient Care Team/organization & administration
MH  - Phospholipids/therapeutic use
MH  - Prospective Studies
MH  - Short Bowel Syndrome/*rehabilitation/surgery/therapy
MH  - Soybean Oil/therapeutic use
MH  - Survival Rate
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2011/01/18 06:00
MHDA- 2011/06/28 06:00
CRDT- 2011/01/18 06:00
PHST- 2010/09/22 00:00 [received]
PHST- 2010/09/30 00:00 [accepted]
PHST- 2011/01/18 06:00 [entrez]
PHST- 2011/01/18 06:00 [pubmed]
PHST- 2011/06/28 06:00 [medline]
AID - S0022-3468(10)00904-8 [pii]
AID - 10.1016/j.jpedsurg.2010.09.083 [doi]
PST - ppublish
SO  - J Pediatr Surg. 2011 Jan;46(1):150-6. doi: 10.1016/j.jpedsurg.2010.09.083.


PMID- 21237598
OWN - NLM
STAT- MEDLINE
DCOM- 20120517
LR  - 20161125
IS  - 1872-7727 (Electronic)
IS  - 0720-048X (Linking)
VI  - 81
IP  - 2
DP  - 2012 Feb
TI  - The value of strain ratio in differential diagnosis of thyroid solid nodules.
PG  - 286-91
LID - 10.1016/j.ejrad.2010.12.010 [doi]
AB  - OBJECTIVE: To assess the clinical value of strain ratio in differentiating
      thyroid solid nodules and explore its distribution characters based on
      pathological results. MATERIALS AND METHODS: The study was approved by the ethic 
      committee and the informed consents were signed. Ninety nine solid thyroid
      nodules (67 benign and 32 malignant) from 71 female (mean age 46.3 +/- 9.8 years)
      and 28 male (mean age 54.9 +/- 11.7 years) patients were evaluated. Five
      radiologists evaluated the nodules based on a four-degree elastography score
      system. Strain ratio was calculated on-line. Diagnostic performances of the two
      evaluations were compared using Receiver Operating Characteristic (ROC) curves.
      Values of different pathological nodules were compared by one-way ANOVA. RESULTS:
      Areas under the ROC curve (AUC) of the five readers were 0.82, 0.81, 0.79, 0.73
      and 0.83, respectively. The AUC of strain ratio evaluation was higher (0.88 vs.
      0.79, p < 0.001) than that of the ES score evaluation. Best cut-off points of the
      two evaluations were 3.5 (82% sensitivity, 72% specificity) and 4.225 (81%
      sensitivity, 83% specificity), respectively. Both the ES score and strain ratio
      were higher for malignant nodules than that for benign ones (p < 0.001).
      CONCLUSIONS: Strain ratio was a useful index in differential diagnosis of thyroid
      solid nodules. It can provide quantitative information on thyroid nodule
      characterization and improve diagnostic confidence. The best cut-off point for
      benign and malignant nodules was 4.2.
CI  - Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Ning, Chun-Ping
AU  - Ning CP
AD  - Department of Ultrasound, Second Affiliated Hospital of Harbin Medical
      University, Harbin 150081, PR China.
FAU - Jiang, Shuang-Quan
AU  - Jiang SQ
FAU - Zhang, Tao
AU  - Zhang T
FAU - Sun, Li-tao
AU  - Sun LT
FAU - Liu, Yu-Jie
AU  - Liu YJ
FAU - Tian, Jia-Wei
AU  - Tian JW
LA  - eng
PT  - Journal Article
DEP - 20110114
PL  - Ireland
TA  - Eur J Radiol
JT  - European journal of radiology
JID - 8106411
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anisotropy
MH  - Child
MH  - Elastic Modulus
MH  - Elasticity Imaging Techniques/*methods
MH  - Female
MH  - Humans
MH  - Image Interpretation, Computer-Assisted/*methods
MH  - Male
MH  - Middle Aged
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Thyroid Nodule/*diagnostic imaging/*physiopathology
MH  - Young Adult
EDAT- 2011/01/18 06:00
MHDA- 2012/05/18 06:00
CRDT- 2011/01/18 06:00
PHST- 2010/09/14 00:00 [received]
PHST- 2010/11/25 00:00 [revised]
PHST- 2010/12/02 00:00 [accepted]
PHST- 2011/01/18 06:00 [entrez]
PHST- 2011/01/18 06:00 [pubmed]
PHST- 2012/05/18 06:00 [medline]
AID - S0720-048X(10)00604-2 [pii]
AID - 10.1016/j.ejrad.2010.12.010 [doi]
PST - ppublish
SO  - Eur J Radiol. 2012 Feb;81(2):286-91. doi: 10.1016/j.ejrad.2010.12.010. Epub 2011 
      Jan 14.


PMID- 21235768
OWN - NLM
STAT- MEDLINE
DCOM- 20110311
LR  - 20211020
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 12
DP  - 2011 Jan 14
TI  - Informed consent for MRI and fMRI research: analysis of a sample of Canadian
      consent documents.
PG  - 1
LID - 10.1186/1472-6939-12-1 [doi]
AB  - BACKGROUND: Research ethics and the measures deployed to ensure ethical oversight
      of research (e.g., informed consent forms, ethics review) are vested with
      extremely important ethical and practical goals. Accordingly, these measures need
      to function effectively in real-world research and to follow high level
      standards. METHODS: We examined approved consent forms for Magnetic Resonance
      Imaging (MRI) and functional Magnetic Resonance Imaging (fMRI) studies approved
      by Canadian research ethics boards (REBs). RESULTS: We found evidence of
      variability in consent forms in matters of physical and psychological risk
      reporting. Approaches used to tackle the emerging issue of incidental findings
      exposed extensive variability between and within research sites. CONCLUSION: The 
      causes of variability in approved consent forms and studies need to be better
      understood. However, mounting evidence of administrative and practical hurdles
      within current ethics governance systems combined with potential sub-optimal
      provision of information to and protection of research subjects support other
      calls for more scrutiny of research ethics practices and applicable revisions.
FAU - Palmour, Nicole
AU  - Palmour N
AD  - Neuroethics Research Unit, Institut de recherches cliniques de Montreal, Canada.
FAU - Affleck, William
AU  - Affleck W
FAU - Bell, Emily
AU  - Bell E
FAU - Deslauriers, Constance
AU  - Deslauriers C
FAU - Pike, Bruce
AU  - Pike B
FAU - Doyon, Julien
AU  - Doyon J
FAU - Racine, Eric
AU  - Racine E
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110114
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Canada
MH  - Comprehension
MH  - *Consent Forms/ethics/standards
MH  - Ethics Committees, Research
MH  - Humans
MH  - Incidental Findings
MH  - Informed Consent/*ethics
MH  - *Magnetic Resonance Imaging/ethics
MH  - Nontherapeutic Human Experimentation/ethics
MH  - Research Subjects
MH  - Retrospective Studies
PMC - PMC3033859
EDAT- 2011/01/18 06:00
MHDA- 2011/03/12 06:00
CRDT- 2011/01/18 06:00
PHST- 2010/09/17 00:00 [received]
PHST- 2011/01/14 00:00 [accepted]
PHST- 2011/01/18 06:00 [entrez]
PHST- 2011/01/18 06:00 [pubmed]
PHST- 2011/03/12 06:00 [medline]
AID - 1472-6939-12-1 [pii]
AID - 10.1186/1472-6939-12-1 [doi]
PST - epublish
SO  - BMC Med Ethics. 2011 Jan 14;12:1. doi: 10.1186/1472-6939-12-1.


PMID- 21234812
OWN - NLM
STAT- MEDLINE
DCOM- 20110523
LR  - 20110208
IS  - 1661-4917 (Electronic)
IS  - 0004-069X (Linking)
VI  - 59
IP  - 1
DP  - 2011 Feb
TI  - Legal and ethical aspects of ghostwriting in medicine.
PG  - 1-9
LID - 10.1007/s00005-010-0105-y [doi]
AB  - Ghostwriting in medicine represents a highly significant problem in both legal
      and ethical terms, and particularly in recent years owing to a sudden increase in
      the practice. The main goal in this paper is to present the legal and ethical
      rules connected with the ghostwriting phenomenon. The problem is presented in the
      context of international, European and Polish law. From a legal perspective the
      issues bound up with ghostwriting are those of the notion and authorship of a
      work, authors' rights (both moral rights and copyright), the content of these
      rights and their nature, as well as the question of the transfer of such rights. 
      From the point of view of ethics there arises a need for reflection on honesty,
      accuracy and credibility as defined both generally and scientifically.
FAU - Wnukiewicz-Kozlowska, Agata
AU  - Wnukiewicz-Kozlowska A
AD  - Chair of Public International and European Law, Faculty of Law, Administration
      and Economics, University of Wroclaw, Uniwersytecka 22/26, 50-145, Wroclaw,
      Poland. wnukiewicz@prawo.uni.wroc.pl
LA  - eng
PT  - Journal Article
DEP - 20110114
PL  - Switzerland
TA  - Arch Immunol Ther Exp (Warsz)
JT  - Archivum immunologiae et therapiae experimentalis
JID - 0114365
SB  - IM
MH  - *Authorship
MH  - Conflict of Interest
MH  - *Copyright/ethics/legislation & jurisprudence
MH  - Humans
MH  - Patient Rights
MH  - *Publishing/ethics/legislation & jurisprudence
MH  - *Truth Disclosure
MH  - *Writing
EDAT- 2011/01/15 06:00
MHDA- 2011/05/24 06:00
CRDT- 2011/01/15 06:00
PHST- 2010/07/15 00:00 [received]
PHST- 2010/08/06 00:00 [accepted]
PHST- 2011/01/15 06:00 [entrez]
PHST- 2011/01/15 06:00 [pubmed]
PHST- 2011/05/24 06:00 [medline]
AID - 10.1007/s00005-010-0105-y [doi]
PST - ppublish
SO  - Arch Immunol Ther Exp (Warsz). 2011 Feb;59(1):1-9. doi:
      10.1007/s00005-010-0105-y. Epub 2011 Jan 14.


PMID- 21234271
OWN - NLM
STAT- MEDLINE
DCOM- 20110621
LR  - 20211020
IS  - 1449-1907 (Electronic)
IS  - 1449-1907 (Linking)
VI  - 8
IP  - 1
DP  - 2011 Jan 8
TI  - Two-year outcome of Turkish patients treated with Zotarolimus versus Paclitaxel
      eluting stents in an unselected population with coronary artery disease in the
      real world: a prospective non-randomized registry in southern Turkey.
PG  - 68-73
AB  - BACKGROUND: Our purpose was to investigate the clinical outcomes of Zotarolimus- 
      and Paclitaxel-eluting stents in Turkish patients with coronary artery disease
      (CAD). In general, the outcome of drug-eluting stent (DES) placement has a proven
      efficacy in randomized trials. However, the difference in efficacy between the
      Zotarolimus and Paclitaxel-eluting stents in unselected Turkish patients is
      controversial. Therefore, we investigated the clinical outcomes of these two
      drug-eluting stents in the real-world. METHODS: We created a registry and
      prospectively analyzed data on a consecutive series of all patients who presented
      to our institution with symptomatic coronary artery disease between February 2005
      and March 2007 and who were treated with the zotarolimus- or the
      paclitaxel-eluting stent. The follow-up period was approximately two years. The
      primary end-point was major cardiac events, and the secondary end-point was
      definite stent thrombosis. Informed consent was obtained from all subjects, and
      the study protocol was approved by the local ethical committee. RESULTS: In
      total, 217 patients were treated with either the zotarolimus-eluting stent (n =
      116) or the paclitaxel-eluting stent (n = 101). The lesions in the 2 arms of the 
      study were treated similarly by conventional technique. At 24-month follow-up the
      paclitaxel-eluting stent group showed significantly higher non-Q wave myocardial 
      infarction (2.6% vs 5.9%, p: 0.02), Q wave myocardial infarction (1.7% vs 5.9%,
      p: 0.049), coronary artery binding graft surgery (2.6% vs 6.9%, p: 0.002), and
      late stent thrombosis (1.7% vs 3.9%, p: 0.046). CONCLUSIONS: Zotarolimus-eluting 
      stents demonstrated better clinical outcomes than Paclitaxel-eluting stents in a 
      daily routine practice of coronary intervention in an unselected Turkish
      population.
FAU - Cicek, Davran
AU  - Cicek D
AD  - Baskent University School of Medicine, Department of Cardiology, Antalya.
      davrancicek@mynet.com
FAU - Pekdemir, Hasan
AU  - Pekdemir H
FAU - Haberal, Cevahir
AU  - Haberal C
FAU - Kalay, Nihat
AU  - Kalay N
FAU - Binici, Suleyman
AU  - Binici S
FAU - Altay, Hakan
AU  - Altay H
FAU - Muderrisoglu, Haldun
AU  - Muderrisoglu H
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20110108
PL  - Australia
TA  - Int J Med Sci
JT  - International journal of medical sciences
JID - 101213954
RN  - 0 (Cardiovascular Agents)
RN  - H4GXR80IZE (zotarolimus)
RN  - P88XT4IS4D (Paclitaxel)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
MH  - Aged
MH  - Cardiovascular Agents/administration & dosage
MH  - Coronary Artery Disease/*drug therapy/epidemiology/surgery
MH  - *Drug-Eluting Stents/adverse effects
MH  - Follow-Up Studies
MH  - Humans
MH  - Middle Aged
MH  - Paclitaxel/*administration & dosage/adverse effects
MH  - Patient Selection
MH  - Postoperative Complications/epidemiology
MH  - Prospective Studies
MH  - Random Allocation
MH  - Registries
MH  - Retrospective Studies
MH  - Sirolimus/administration & dosage/adverse effects/*analogs & derivatives
MH  - Thrombosis/epidemiology
MH  - Time Factors
MH  - Treatment Outcome
MH  - Turkey
PMC - PMC3020394
OTO - NOTNLM
OT  - coronary artery disease
OT  - drug-eluting stent
OT  - major adverse cardiac event
OT  - stent thrombosis.
EDAT- 2011/01/15 06:00
MHDA- 2011/06/22 06:00
CRDT- 2011/01/15 06:00
PHST- 2010/06/18 00:00 [received]
PHST- 2011/01/01 00:00 [accepted]
PHST- 2011/01/15 06:00 [entrez]
PHST- 2011/01/15 06:00 [pubmed]
PHST- 2011/06/22 06:00 [medline]
AID - 10.7150/ijms.8.68 [doi]
PST - epublish
SO  - Int J Med Sci. 2011 Jan 8;8(1):68-73. doi: 10.7150/ijms.8.68.


PMID- 21233436
OWN - NLM
STAT- MEDLINE
DCOM- 20110329
LR  - 20211020
IS  - 1541-0048 (Electronic)
IS  - 0090-0036 (Linking)
VI  - 101
IP  - 3
DP  - 2011 Mar
TI  - Evidence, ethics, and values: a framework for health promotion.
PG  - 465-72
LID - 10.2105/AJPH.2010.195545 [doi]
AB  - We propose a new approach to guide health promotion practice. Health promotion
      should draw on 2 related systems of reasoning: an evidential system and an
      ethical system. Further, there are concepts, values, and procedures inherent in
      both health promotion evidence and ethics, and these should be made explicit. We 
      illustrate our approach with the exemplar of intervention in weight, and use a
      specific mass-media campaign to show the real-world dangers of intervening with
      insufficient attention to ethics and evidence. Both researchers and health
      promotion practitioners should work to build the capacities required for
      evidential and ethical deliberation in the health promotion profession.
FAU - Carter, Stacy M
AU  - Carter SM
AD  - Centre for Values, Ethics and the Law in Medicine and Sydney School of Public
      Health, University of Sydney, Sydney, NSW, Australia. stacy.carter@sydney.edu.au
FAU - Rychetnik, Lucie
AU  - Rychetnik L
FAU - Lloyd, Beverley
AU  - Lloyd B
FAU - Kerridge, Ian H
AU  - Kerridge IH
FAU - Baur, Louise
AU  - Baur L
FAU - Bauman, Adrian
AU  - Bauman A
FAU - Hooker, Claire
AU  - Hooker C
FAU - Zask, Avigdor
AU  - Zask A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110113
PL  - United States
TA  - Am J Public Health
JT  - American journal of public health
JID - 1254074
SB  - IM
MH  - Body Mass Index
MH  - Coercion
MH  - Evidence-Based Medicine
MH  - Health Promotion/ethics/*organization & administration
MH  - Humans
MH  - Mass Media
MH  - Obesity/*prevention & control
MH  - *Public Health Practice/ethics
MH  - Social Values
MH  - Stereotyping
MH  - United States/epidemiology
PMC - PMC3036693
EDAT- 2011/01/15 06:00
MHDA- 2011/03/30 06:00
CRDT- 2011/01/15 06:00
PHST- 2011/01/15 06:00 [entrez]
PHST- 2011/01/15 06:00 [pubmed]
PHST- 2011/03/30 06:00 [medline]
AID - AJPH.2010.195545 [pii]
AID - 10.2105/AJPH.2010.195545 [doi]
PST - ppublish
SO  - Am J Public Health. 2011 Mar;101(3):465-72. doi: 10.2105/AJPH.2010.195545. Epub
      2011 Jan 13.


PMID- 21232730
OWN - NLM
STAT- MEDLINE
DCOM- 20110408
LR  - 20220409
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 151
IP  - 3
DP  - 2011 Mar
TI  - Transcorneal suture fixation of posterior lamellar grafts in eyes with minimal or
      absent iris-lens diaphragm.
PG  - 460-4.e2
LID - 10.1016/j.ajo.2010.08.043 [doi]
AB  - PURPOSE: To describe a technique that uses a transcorneal suture for safe
      delivery and fixation of donor tissue during Descemet stripping automated
      endothelial keratoplasty in patients that are at risk of graft dislocation into
      the vitreous cavity as a result of minimal or absent iris-lens diaphragm. DESIGN:
      Interventional case series. METHODS: Thirteen eyes with endothelial
      decompensation and inadequate iris-lens diaphragm underwent modified Descemet
      stripping automated endothelial keratoplasty surgery. A 10-0 Prolene suture
      (Ethicon Inc) was passed through the endothelial graft and used to pull the graft
      into the eye and anchor it onto the recipient cornea. Best-corrected visual
      acuity, refraction, and complications were recorded. RESULTS: Preoperative
      best-corrected visual acuity was less than 20/200 in all cases. Eleven patients
      had a pre-existing comorbidity (glaucoma, n = 8; previous retinal detachment, n =
      2; epiretinal membrane n = 1). Average follow-up was 11.3 months (range, 3 to 36 
      months). No graft dislocation occurred during surgery. After surgery, graft
      detachment was noted in 2 cases and rebubbling succeeded in achieving
      reattachment. All patients had successful attachment of the endothelial graft.
      Postoperative best-corrected visual acuity improved in 11 of 13 patients and
      remained unchanged in 2 patients. CONCLUSIONS: In patients with insufficient
      iris-lens diaphragm, this technique allowed safe graft delivery, prevented
      intraoperative and postoperative graft dislocation, and facilitated successful
      rebubbling in case of postoperative graft detachment.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Patel, Amit K
AU  - Patel AK
AD  - Department of Ophthalmology, Villa Serena Hospital, Forli, Italy.
      amitpatel@doctors.org.uk
FAU - Luccarelli, Saverio
AU  - Luccarelli S
FAU - Ponzin, Diego
AU  - Ponzin D
FAU - Busin, Massimo
AU  - Busin M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110112
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aphakia, Postcataract/complications/*surgery
MH  - Cornea/surgery
MH  - Descemet Stripping Endothelial Keratoplasty/*methods
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Intraoperative Complications/prevention & control
MH  - Iris Diseases/complications/*surgery
MH  - Male
MH  - Middle Aged
MH  - Postoperative Complications/prevention & control
MH  - Prospective Studies
MH  - Pseudophakia/complications/*surgery
MH  - Refraction, Ocular/physiology
MH  - *Suture Techniques
MH  - Visual Acuity/physiology
EDAT- 2011/01/15 06:00
MHDA- 2011/04/09 06:00
CRDT- 2011/01/15 06:00
PHST- 2010/05/31 00:00 [received]
PHST- 2010/08/28 00:00 [revised]
PHST- 2010/08/31 00:00 [accepted]
PHST- 2011/01/15 06:00 [entrez]
PHST- 2011/01/15 06:00 [pubmed]
PHST- 2011/04/09 06:00 [medline]
AID - S0002-9394(10)00686-0 [pii]
AID - 10.1016/j.ajo.2010.08.043 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2011 Mar;151(3):460-4.e2. doi: 10.1016/j.ajo.2010.08.043. Epub
      2011 Jan 12.


PMID- 21231955
OWN - NLM
STAT- MEDLINE
DCOM- 20110722
LR  - 20110412
IS  - 1365-2648 (Electronic)
IS  - 0309-2402 (Linking)
VI  - 67
IP  - 5
DP  - 2011 May
TI  - Ethical considerations in the study of online illness narratives: a qualitative
      review.
PG  - 945-53
LID - 10.1111/j.1365-2648.2010.05563.x [doi]
AB  - AIM: This aim of the review was to describe differences in ethical approaches to 
      research on Internet communication during illness and to report conclusions drawn
      relevant to a proposed narrative analysis of parent blogs of childhood illness.
      BACKGROUND: As the study of the online expression of illness experiences becomes 
      more expansive, discussion of related ethical issues is central to promoting
      research trustworthiness and rigour. Ethical considerations are central to the
      patient-provider relationship. DATA SOURCES: The EBSCO Host, CINAHL, Medline,
      Communication & Mass Media Complete, and Google Scholar databases were searched
      from January 1990 to September 2009 using the terms 'Internet research and
      ethics', 'Internet research, illness and ethics' and 'blog, Internet research and
      ethics'. Of the 4114 references found, 21 met the inclusion criteria for the
      review. REVIEW METHODS: The review was designed to be a comprehensive assessment 
      of the concepts analysed and the qualitative research measures taken concerning
      ethics in Internet research across formats. RESULTS: Three main approaches to
      ethical conduct in Internet research on illness experiences were found: human
      subjects, representation and open source approaches. CONCLUSION: The personal and
      sensitive nature of online illness narratives demand their consideration in
      health care as 'human subjects' research. The best hope for ethical treatment of 
      author-participants is the creation of a comprehensive plan for addressing any
      and all potential ethical conflicts that may arise in the collection, analysis
      and reporting of data, taking into consideration rapid changes in technology.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Heilferty, Catherine McGeehin
AU  - Heilferty CM
AD  - School of Nursing and Allied Health Professions Holy Family University,
      Philadelphia, Pennsylvania, USA. cheilferty@holyfamily.edu
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110113
PL  - England
TA  - J Adv Nurs
JT  - Journal of advanced nursing
JID - 7609811
SB  - IM
MH  - Blogging/*ethics
MH  - Child
MH  - Communication
MH  - Decision Making/ethics
MH  - *Ethics, Research
MH  - Female
MH  - Humans
MH  - Informed Consent/ethics
MH  - Internet/*ethics
MH  - *Narration
MH  - Nursing Methodology Research
MH  - Parents
MH  - Privacy
MH  - *Qualitative Research
MH  - Research Design
MH  - Research Subjects
MH  - Researcher-Subject Relations/ethics
EDAT- 2011/01/15 06:00
MHDA- 2011/07/23 06:00
CRDT- 2011/01/15 06:00
PHST- 2011/01/15 06:00 [entrez]
PHST- 2011/01/15 06:00 [pubmed]
PHST- 2011/07/23 06:00 [medline]
AID - 10.1111/j.1365-2648.2010.05563.x [doi]
PST - ppublish
SO  - J Adv Nurs. 2011 May;67(5):945-53. doi: 10.1111/j.1365-2648.2010.05563.x. Epub
      2011 Jan 13.


PMID- 21231854
OWN - NLM
STAT- MEDLINE
DCOM- 20110523
LR  - 20110204
IS  - 1369-1635 (Electronic)
IS  - 0953-7104 (Linking)
VI  - 22
IP  - 2
DP  - 2011
TI  - Clearance of platelet microparticles in vivo.
PG  - 111-6
LID - 10.3109/09537104.2010.520373 [doi]
AB  - At present, little is known about the clearance of platelet-derived
      microparticles (PMP) in human blood, as due to ethical considerations infusion
      experiments with labeled microparticles are delicate. Therefore, we investigated 
      the kinetics of PMP, which are abundantly present in apheresis platelet
      concentrates (PC), following platelet transfusion in severe thrombocytopenic
      patients (n=11). PMP were double-stained with annexin V and cell-specific
      antibodies (anti-CD61, anti-CD63 or anti-CD62P, respectively) and detected by
      flow cytometry before and after transfusion of a single PC at fixed time
      intervals. Upon transfusion, the plasma levels of MP binding annexin V
      (2.5-fold), PMP (CD61+; 2.9-fold), and PMP from activated platelets (CD63+;
      1.9-fold) or P-selectin (2.5-fold) increased immediately. The plasma levels of MP
      decreased with a half life of 5.8 hours (annexin V; 95% CI: 1.8?18.3) and 5.3
      hours (CD61; 95% CI: 2.0?14.2). This is the first report in which the half life
      time of transfused PMP has been investigated in humans.
FAU - Rank, A
AU  - Rank A
AD  - Medizinische Klinik III-Grosshadern, Klinikum der Ludwig Maximilians-Universitat 
      Munchen, Munchen, Germany. andreas.rank@med.uni-muenchen.de
FAU - Nieuwland, R
AU  - Nieuwland R
FAU - Crispin, A
AU  - Crispin A
FAU - Grutzner, S
AU  - Grutzner S
FAU - Iberer, M
AU  - Iberer M
FAU - Toth, B
AU  - Toth B
FAU - Pihusch, R
AU  - Pihusch R
LA  - eng
PT  - Journal Article
DEP - 20110113
PL  - England
TA  - Platelets
JT  - Platelets
JID - 9208117
RN  - 0 (Annexin A5)
RN  - 0 (Antigens, CD)
RN  - 0 (P-Selectin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Annexin A5/metabolism
MH  - Antigens, CD/metabolism
MH  - Blood Platelets/*metabolism
MH  - Cell-Derived Microparticles/*metabolism
MH  - Female
MH  - Half-Life
MH  - Humans
MH  - Kinetics
MH  - Male
MH  - Middle Aged
MH  - P-Selectin/metabolism
MH  - Platelet Count
MH  - Platelet Transfusion
MH  - Young Adult
EDAT- 2011/01/15 06:00
MHDA- 2011/05/24 06:00
CRDT- 2011/01/15 06:00
PHST- 2011/01/15 06:00 [entrez]
PHST- 2011/01/15 06:00 [pubmed]
PHST- 2011/05/24 06:00 [medline]
AID - 10.3109/09537104.2010.520373 [doi]
PST - ppublish
SO  - Platelets. 2011;22(2):111-6. doi: 10.3109/09537104.2010.520373. Epub 2011 Jan 13.


PMID- 21231850
OWN - NLM
STAT- MEDLINE
DCOM- 20120315
LR  - 20111109
IS  - 1476-4954 (Electronic)
IS  - 1476-4954 (Linking)
VI  - 24
IP  - 12
DP  - 2011 Dec
TI  - Congenital rubella syndrome: seeking damages to be born. Ethical, medical and
      public health considerations.
PG  - 1417-20
LID - 10.3109/14767058.2010.545927 [doi]
AB  - A case of congenital rubella syndrome has been the reason to seek damages but a
      Civil Court of Rome sentenced against this and in favor of sued doctors. We
      discussed the high level of social attention and the feeling present in our
      western culture behind the request for damages. Legal considerations above the
      Italian abortion Law is provided to understand the framework of the court
      decision. Ethical, medical, and public health issues are commented and compared
      with the Perruche's case.
FAU - Verghini, Emanuele
AU  - Verghini E
AD  - Body of Lawyers of the City of Rome, Rome, Italy.
FAU - Di Pietro, Maria Luisa
AU  - Di Pietro ML
FAU - Virdis, Andrea
AU  - Virdis A
FAU - De Luca, Daniele
AU  - De Luca D
LA  - eng
PT  - Case Reports
PT  - Comparative Study
PT  - Journal Article
DEP - 20110113
PL  - England
TA  - J Matern Fetal Neonatal Med
JT  - The journal of maternal-fetal & neonatal medicine : the official journal of the
      European Association of Perinatal Medicine, the Federation of Asia and Oceania
      Perinatal Societies, the International Society of Perinatal Obstetricians
JID - 101136916
SB  - IM
MH  - Compensation and Redress/*ethics/*legislation & jurisprudence
MH  - Delayed Diagnosis/legislation & jurisprudence
MH  - Diagnostic Errors/legislation & jurisprudence
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - *Jurisprudence
MH  - Morals
MH  - Patient Rights
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/diagnosis/therapy
MH  - *Public Health/ethics/legislation & jurisprudence/methods
MH  - *Rubella Syndrome, Congenital/diagnosis/therapy
EDAT- 2011/01/15 06:00
MHDA- 2012/03/16 06:00
CRDT- 2011/01/15 06:00
PHST- 2011/01/15 06:00 [entrez]
PHST- 2011/01/15 06:00 [pubmed]
PHST- 2012/03/16 06:00 [medline]
AID - 10.3109/14767058.2010.545927 [doi]
PST - ppublish
SO  - J Matern Fetal Neonatal Med. 2011 Dec;24(12):1417-20. doi:
      10.3109/14767058.2010.545927. Epub 2011 Jan 13.


PMID- 21229263
OWN - NLM
STAT- MEDLINE
DCOM- 20110715
LR  - 20220318
IS  - 1432-1955 (Electronic)
IS  - 0932-0113 (Linking)
VI  - 108
IP  - 4
DP  - 2011 Apr
TI  - Malaria vector control: from past to future.
PG  - 757-79
LID - 10.1007/s00436-010-2232-0 [doi]
AB  - Malaria is one of the most common vector-borne diseases widespread in the
      tropical and subtropical regions. Despite considerable success of malaria control
      programs in the past, malaria still continues as a major public health problem in
      several countries. Vector control is an essential part for reducing malaria
      transmission and became less effective in recent years, due to many technical and
      administrative reasons, including poor or no adoption of alternative tools. Of
      the different strategies available for vector control, the most successful are
      indoor residual spraying and insecticide-treated nets (ITNs), including
      long-lasting ITNs and materials. Earlier DDT spray has shown spectacular success 
      in decimating disease vectors but resulted in development of insecticide
      resistance, and to control the resistant mosquitoes, organophosphates,
      carbamates, and synthetic pyrethroids were introduced in indoor residual spraying
      with needed success but subsequently resulted in the development of widespread
      multiple insecticide resistance in vectors. Vector control in many countries
      still use insecticides in the absence of viable alternatives. Few developments
      for vector control, using ovitraps, space spray, biological control agents, etc.,
      were encouraging when used in limited scale. Likewise, recent introduction of
      safer vector control agents, such as insect growth regulators, biocontrol agents,
      and natural plant products have yet to gain the needed scale of utility for
      vector control. Bacterial pesticides are promising and are effective in many
      countries. Environmental management has shown sufficient promise for vector
      control and disease management but still needs advocacy for inter-sectoral
      coordination and sometimes are very work-intensive. The more recent genetic
      manipulation and sterile insect techniques are under development and
      consideration for use in routine vector control and for these, standardized
      procedures and methods are available but need thorough understanding of biology, 
      ethical considerations, and sufficiently trained manpower for implementation
      being technically intensive methods. All the methods mentioned in the review that
      are being implemented or proposed for implementation needs effective
      inter-sectoral coordination and community participation. The latest strategy is
      evolution-proof insecticides that include fungal biopesticides, Wolbachia, and
      Denso virus that essentially manipulate the life cycle of the mosquitoes were
      found effective but needs more research. However, for effective vector control,
      integrated vector management methods, involving use of combination of effective
      tools, is needed and is also suggested by Global Malaria Control Strategy. This
      review article raises issues associated with the present-day vector control
      strategies and state opportunities with a focus on ongoing research and recent
      advances to enable to sustain the gains achieved so far.
FAU - Raghavendra, Kamaraju
AU  - Raghavendra K
AD  - Vector Control Division, National Institute of Malaria Research (ICMR), Sector 8,
      Dwarka, New Delhi, 110 077, India. kamarajur2000@yahoo.com
FAU - Barik, Tapan K
AU  - Barik TK
FAU - Reddy, B P Niranjan
AU  - Reddy BP
FAU - Sharma, Poonam
AU  - Sharma P
FAU - Dash, Aditya P
AU  - Dash AP
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Review
DEP - 20110113
PL  - Germany
TA  - Parasitol Res
JT  - Parasitology research
JID - 8703571
RN  - 0 (Insecticides)
SB  - IM
MH  - Animals
MH  - Drug Resistance
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Insecticides/pharmacology
MH  - Malaria/*epidemiology/*prevention & control/transmission
MH  - Mosquito Control/*history/*methods
MH  - Pest Control, Biological/methods
EDAT- 2011/01/14 06:00
MHDA- 2011/07/16 06:00
CRDT- 2011/01/14 06:00
PHST- 2010/08/02 00:00 [received]
PHST- 2010/10/06 00:00 [accepted]
PHST- 2011/01/14 06:00 [entrez]
PHST- 2011/01/14 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
AID - 10.1007/s00436-010-2232-0 [doi]
PST - ppublish
SO  - Parasitol Res. 2011 Apr;108(4):757-79. doi: 10.1007/s00436-010-2232-0. Epub 2011 
      Jan 13.


PMID- 21228672
OWN - NLM
STAT- MEDLINE
DCOM- 20110217
LR  - 20110113
IS  - 1530-0358 (Electronic)
IS  - 0012-3706 (Linking)
VI  - 54
IP  - 2
DP  - 2011 Feb
TI  - Phantom publications among applicants to a colorectal surgery residency program.
PG  - 220-5
LID - 10.1007/DCR.0b013e3181fb0e7a [doi]
AB  - BACKGROUND: Previous studies have reported that as many as one third of
      applicants misrepresent their publication record on residency or fellowship
      applications. OBJECTIVE: To determine the incidence of potentially fraudulent (or
      "phantom") research publications among applicants to a colorectal surgery
      residency program. DESIGN: Electronic Residency Application Services applications
      were reviewed. All listed publications were tabulated and checked whether they
      were published using various search engines. SETTING: Cedars-Sinai Medical
      Center. PATIENTS: Applicants from 2006 to 2008. MAIN OUTCOME MEASURES: We
      searched for phantom publications, defined as peer review journal citations that 
      could not be verified. Demographics and other academic factors were compared
      between applicants with phantom publications and applicants with verifiable
      publications. RESULTS: Of the 133 study group applicants, there were 91 (68%)
      males and 58 (44%) whites. Median age of the study cohort was 32 years (range,
      27-48 y). Eight-seven of 130 applicants (65%) listed a total of 392 publications.
      Thirty-six (9%) of these 392 citations could not be verified and were considered 
      to be phantom publications. The 36 phantom publications were identified in 21
      applicants, representing 16% (21/133) of all applicants and 24% (21/87) of all
      applicants who cited publications. We found no significant difference in any
      demographic or other studied variable between applicants with phantom
      publications and those with verifiable publications. When comparing applicants
      with 3 or more phantom publications with applicants with verifiable publications,
      the former group had a significantly higher rate of individuals over age 35 (50% 
      vs 24%; P = .02), foreign medical school graduates (75% vs 20%; P = .03), and
      individuals with 5 or more publications (100% vs 30%; P = .01). LIMITATIONS:
      Publications may simply have been missed in our search. We specifically may have 
      failed to find publications in foreign journals. CONCLUSION: The significance of 
      professionalism and ethical behavior must be emphasized in surgery training
      programs.
FAU - Nasseri, Yosef
AU  - Nasseri Y
AD  - Division of Colorectal Surgery, Cedars-Sinai Medical Center, Los Angeles,
      California, USA.
FAU - Kohanzadeh, Som
AU  - Kohanzadeh S
FAU - Murrell, Zuri
AU  - Murrell Z
FAU - Berel, Dror
AU  - Berel D
FAU - Melmed, Gil
AU  - Melmed G
FAU - Fleshner, Phillip
AU  - Fleshner P
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Dis Colon Rectum
JT  - Diseases of the colon and rectum
JID - 0372764
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - *Authorship
MH  - California
MH  - Colorectal Surgery/*education
MH  - Female
MH  - Foreign Medical Graduates
MH  - *Fraud
MH  - Humans
MH  - *Internship and Residency
MH  - Job Application
MH  - Male
MH  - Middle Aged
MH  - *Publications
EDAT- 2011/01/14 06:00
MHDA- 2011/02/18 06:00
CRDT- 2011/01/14 06:00
PHST- 2011/01/14 06:00 [entrez]
PHST- 2011/01/14 06:00 [pubmed]
PHST- 2011/02/18 06:00 [medline]
AID - 10.1007/DCR.0b013e3181fb0e7a [doi]
AID - 00003453-201102000-00016 [pii]
PST - ppublish
SO  - Dis Colon Rectum. 2011 Feb;54(2):220-5. doi: 10.1007/DCR.0b013e3181fb0e7a.


PMID- 21228433
OWN - NLM
STAT- MEDLINE
DCOM- 20110725
LR  - 20130520
IS  - 2044-5423 (Electronic)
IS  - 2044-5415 (Linking)
VI  - 20
IP  - 4
DP  - 2011 Apr
TI  - Implementation of the process of ethical review of improvement activities at the 
      Children's Hospital at Westmead.
PG  - 366-71
LID - 10.1136/bmjqs.2010.043869 [doi]
AB  - INTRODUCTION: Research in healthcare has long been very well regulated, but this 
      is rarely the case for improvement activities. Improvement activities are
      activities which use data to assess the current situation to identify areas for
      improvement. Solutions are then developed and implemented, and later evaluated to
      measure their success and sustainability. There has been much discussion in the
      literature as to whether, like research activities, improvement activities should
      undergo independent ethical review. In fact, most healthcare organisations in
      Australia struggle with how best to manage improvement activities, despite the
      2003 publication of the National Health and Medical Research Council guidelines
      on this subject. DISCUSSION: At The Children's Hospital at Westmead, the authors 
      take the view supported by others that ethical review is necessary and so have
      developed a process which utilises the unique skills available in the Clinical
      Governance Unit to ensure improvement activities are reviewed for ethical
      considerations in an effective and efficient manner and implemented a database to
      approve, monitor and report on improvement activities. This has resulted in staff
      being increasingly satisfied with the turnaround time for approval of improvement
      activities they are undertaking as well as for the methodological support
      provided. The authors have experienced a dramatic increase in the number of
      improvement activities being recorded and ethically reviewed.
FAU - Babalis, K
AU  - Babalis K
AD  - The Children's Hospital at Westmead, Australia. kayb4@chw.edu.au
FAU - Harnett, E
AU  - Harnett E
FAU - Steinhoff, K
AU  - Steinhoff K
LA  - eng
PT  - Journal Article
DEP - 20110112
PL  - England
TA  - BMJ Qual Saf
JT  - BMJ quality & safety
JID - 101546984
MH  - Australia
MH  - Child
MH  - Child Health Services/*standards
MH  - Database Management Systems
MH  - *Ethical Review
MH  - Hospitals, Pediatric/*standards
MH  - Humans
MH  - Quality Assurance, Health Care/*organization & administration
EDAT- 2011/01/14 06:00
MHDA- 2011/07/26 06:00
CRDT- 2011/01/14 06:00
PHST- 2011/01/14 06:00 [entrez]
PHST- 2011/01/14 06:00 [pubmed]
PHST- 2011/07/26 06:00 [medline]
AID - bmjqs.2010.043869 [pii]
AID - 10.1136/bmjqs.2010.043869 [doi]
PST - ppublish
SO  - BMJ Qual Saf. 2011 Apr;20(4):366-71. doi: 10.1136/bmjqs.2010.043869. Epub 2011
      Jan 12.


PMID- 21228403
OWN - NLM
STAT- MEDLINE
DCOM- 20120426
LR  - 20131121
IS  - 1552-4604 (Electronic)
IS  - 0091-2700 (Linking)
VI  - 52
IP  - 1
DP  - 2012 Jan
TI  - Ethically attractive dose-finding designs for drugs with a narrow therapeutic
      index.
PG  - 29-38
LID - 10.1177/0091270010390041 [doi]
AB  - A simulation-based comparison study on the relative merits of dose-control trials
      (DCTs) with exposure-response analysis versus concentration-control trials (CCTs)
      for drugs with narrow therapeutic index showed that DCT designs are more
      informative about the exposure-response relationship. The authors revisit the
      question employing optimal design methodology and propose strategies for
      designing ethically attractive trials for these drugs, balancing between
      individual-collective risk and informativeness. An optimal study was performed
      considering a hypothetical immunosuppressant agent with 2 clinical end points.
      Different scenarios were optimized applying cost-based designs (unwanted events
      vs number of subjects/trial or maximal individual risk). Dose/exposure targets
      and number of subjects per trial/arm were optimized. Prior information inclusion 
      on baseline risks was evaluated. DCTs were more informative, needing smaller
      studies to provide the same information as CCTs. Using the number of unwanted
      events-rather than subjects-as cost resulted in ethically more attractive
      designs. Including prior baseline risk information reduced the number of
      subject/events and allowed the use of targets closer to the optimal. Designing
      dose-finding trials for some narrow therapeutic index drugs may be improved by
      using DCTs with exposure-response analysis, cost-based designs, prior
      information, and optimal design analysis providing information on the ethical
      trade-off between individual risk and information gain.
FAU - Lledo-Garcia, Rocio
AU  - Lledo-Garcia R
AD  - Division of Pharmacokinetics and Drug Therapy, Department of Pharmaceutical
      Biosciences, Uppsala University, Box 591, SE 751 24 Uppsala, Sweden.
      rocio.lledo@gmail.com
FAU - Hennig, Stefanie
AU  - Hennig S
FAU - Nyberg, Joakim
AU  - Nyberg J
FAU - Hooker, Andrew C
AU  - Hooker AC
FAU - Karlsson, Mats O
AU  - Karlsson MO
LA  - eng
PT  - Journal Article
DEP - 20110112
PL  - England
TA  - J Clin Pharmacol
JT  - Journal of clinical pharmacology
JID - 0366372
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - *Dose-Response Relationship, Drug
MH  - Drug-Related Side Effects and Adverse Reactions
MH  - Humans
MH  - *Models, Biological
MH  - Pharmaceutical Preparations/*administration & dosage
MH  - Pharmacokinetics
MH  - *Research Design
EDAT- 2011/01/14 06:00
MHDA- 2012/04/27 06:00
CRDT- 2011/01/14 06:00
PHST- 2011/01/14 06:00 [entrez]
PHST- 2011/01/14 06:00 [pubmed]
PHST- 2012/04/27 06:00 [medline]
AID - 0091270010390041 [pii]
AID - 10.1177/0091270010390041 [doi]
PST - ppublish
SO  - J Clin Pharmacol. 2012 Jan;52(1):29-38. doi: 10.1177/0091270010390041. Epub 2011 
      Jan 12.


PMID- 21228396
OWN - NLM
STAT- MEDLINE
DCOM- 20110419
LR  - 20110113
IS  - 1946-6242 (Electronic)
IS  - 1946-6234 (Linking)
VI  - 3
IP  - 65
DP  - 2011 Jan 12
TI  - Molecular technologies open new clinical genetic vistas.
PG  - 65ps2
LID - 10.1126/scitranslmed.3002064 [doi]
AB  - Two recent studies published in Science Translational Medicine (Lo et al., 2010; 
      Bell et al., 2011) demonstrate the potential of applying the latest
      genome-sequencing technologies to preconception carrier testing and noninvasive
      prenatal genetic diagnosis. These studies shine new light on old ethical, legal, 
      and social concerns associated with genetic technology and deserve careful
      discussion.
FAU - Jackson, Laird
AU  - Jackson L
AD  - Department of Obstetrics and Gynecology, Drexel University College of Medicine
      and Division of Genetics, Children's Hospital of Philadelphia, Philadelphia, PA
      19102, USA. laird.jackson@drexelmed.edu
FAU - Pyeritz, Reed E
AU  - Pyeritz RE
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Sci Transl Med
JT  - Science translational medicine
JID - 101505086
SB  - IM
CON - Sci Transl Med. 2010 Dec 8;2(61):61ra91. PMID: 21148127
CON - Sci Transl Med. 2011 Jan 12;3(65):65ra4. PMID: 21228398
MH  - *Cytogenetic Analysis/ethics/methods
MH  - Female
MH  - *Genetic Testing/ethics/methods
MH  - Genome, Human
MH  - Humans
MH  - Mass Screening/ethics/methods
MH  - Pregnancy
MH  - *Prenatal Diagnosis/ethics/methods
EDAT- 2011/01/14 06:00
MHDA- 2011/04/20 06:00
CRDT- 2011/01/14 06:00
PHST- 2011/01/14 06:00 [entrez]
PHST- 2011/01/14 06:00 [pubmed]
PHST- 2011/04/20 06:00 [medline]
AID - 3/65/65ps2 [pii]
AID - 10.1126/scitranslmed.3002064 [doi]
PST - ppublish
SO  - Sci Transl Med. 2011 Jan 12;3(65):65ps2. doi: 10.1126/scitranslmed.3002064.


PMID- 21228284
OWN - NLM
STAT- MEDLINE
DCOM- 20110217
LR  - 20211020
IS  - 1541-0048 (Electronic)
IS  - 0090-0036 (Linking)
VI  - 101
IP  - 2
DP  - 2011 Feb
TI  - Vaccinating health care workers against influenza: the ethical and legal
      rationale for a mandate.
PG  - 212-6
LID - 10.2105/AJPH.2009.190751 [doi]
AB  - Despite improvements in clinician education, symptom awareness, and respiratory
      precautions, influenza vaccination rates for health care workers have remained
      unacceptably low for more than three decades, adversely affecting patient safety.
      When public health is jeopardized, and a safe, low-cost, and effective method to 
      achieve patient safety exists, health care organizations and public health
      authorities have a responsibility to take action and change the status quo.
      Mandatory influenza vaccination for health care workers is supported not only by 
      scientific data but also by ethical principles and legal precedent. The recent
      influenza pandemic provides an opportunity for policymakers to reconsider the
      benefits of mandating influenza vaccination for health care workers, including
      building public trust, enhancing patient safety, and strengthening the health
      care workforce.
FAU - Ottenberg, Abigale L
AU  - Ottenberg AL
AD  - Bioethics Research Program, Mayo Clinic, Rochester, MN 55905, USA.
      ottenberg.abigale@mayo.edu
FAU - Wu, Joel T
AU  - Wu JT
FAU - Poland, Gregory A
AU  - Poland GA
FAU - Jacobson, Robert M
AU  - Jacobson RM
FAU - Koenig, Barbara A
AU  - Koenig BA
FAU - Tilburt, Jon C
AU  - Tilburt JC
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Public Health
JT  - American journal of public health
JID - 1254074
RN  - 0 (Influenza Vaccines)
SB  - IM
MH  - Attitude of Health Personnel
MH  - *Health Personnel
MH  - Humans
MH  - Immunization Programs/*ethics/*legislation & jurisprudence
MH  - Influenza Vaccines/*administration & dosage
MH  - Public Health/ethics/legislation & jurisprudence
MH  - United States
PMC - PMC3020194
EDAT- 2011/01/14 06:00
MHDA- 2011/02/18 06:00
CRDT- 2011/01/14 06:00
PHST- 2011/01/14 06:00 [entrez]
PHST- 2011/01/14 06:00 [pubmed]
PHST- 2011/02/18 06:00 [medline]
AID - 101/2/212 [pii]
AID - 10.2105/AJPH.2009.190751 [doi]
PST - ppublish
SO  - Am J Public Health. 2011 Feb;101(2):212-6. doi: 10.2105/AJPH.2009.190751.


PMID- 21227971
OWN - NLM
STAT- MEDLINE
DCOM- 20110623
LR  - 20211020
IS  - 1471-2954 (Electronic)
IS  - 0962-8452 (Linking)
VI  - 278
IP  - 1707
DP  - 2011 Mar 22
TI  - Information processing in miniature brains.
PG  - 885-8
LID - 10.1098/rspb.2010.2699 [doi]
AB  - Since a comprehensive understanding of brain function and evolution in
      vertebrates is often hobbled by the sheer size of the nervous system, as well as 
      ethical concerns, major research efforts have been made to understand the neural 
      circuitry underpinning behaviour and cognition in invertebrates, and its costs
      and benefits under natural conditions. This special feature of Proceedings of the
      Royal Society B contains an idiosyncratic range of current research perspectives 
      on neural underpinnings and adaptive benefits (and costs) of such diverse
      phenomena as spatial memory, colour vision, attention, spontaneous behaviour
      initiation, memory dynamics, relational rule learning and sleep, in a range of
      animals from marine invertebrates with exquisitely simple nervous systems to
      social insects forming societies with many thousands of individuals working
      together as a 'superorganism'. This introduction provides context and history to 
      tie the various approaches together, and concludes that there is an urgent need
      to understand the full neuron-to-neuron circuitry underlying various forms of
      information processing-not just to explore brain function comprehensively, but
      also to understand how (and how easily) cognitive capacities might evolve in the 
      face of pertinent selection pressures. In the invertebrates, reaching these goals
      is becoming increasingly realistic.
FAU - Chittka, L
AU  - Chittka L
AD  - Queen Mary University of London, Research Centre for Psychology, School of
      Biological and Chemical Sciences, London, UK. l.chittka@qmul.ac.uk
FAU - Skorupski, P
AU  - Skorupski P
LA  - eng
PT  - Introductory Journal Article
DEP - 20110112
PL  - England
TA  - Proc Biol Sci
JT  - Proceedings. Biological sciences
JID - 101245157
SB  - IM
MH  - Animals
MH  - *Behavior, Animal
MH  - Brain/anatomy & histology/*physiology
MH  - Cognition
MH  - Invertebrates/*physiology
MH  - Organ Size
PMC - PMC3049063
EDAT- 2011/01/14 06:00
MHDA- 2011/06/24 06:00
CRDT- 2011/01/14 06:00
PHST- 2011/01/14 06:00 [entrez]
PHST- 2011/01/14 06:00 [pubmed]
PHST- 2011/06/24 06:00 [medline]
AID - rspb.2010.2699 [pii]
AID - 10.1098/rspb.2010.2699 [doi]
PST - ppublish
SO  - Proc Biol Sci. 2011 Mar 22;278(1707):885-8. doi: 10.1098/rspb.2010.2699. Epub
      2011 Jan 12.


PMID- 21227939
OWN - NLM
STAT- MEDLINE
DCOM- 20110715
LR  - 20110316
IS  - 1460-2350 (Electronic)
IS  - 0268-1161 (Linking)
VI  - 26
IP  - 4
DP  - 2011 Apr
TI  - Management of fertility preservation in prepubertal patients: 5 years' experience
      at the Catholic University of Louvain.
PG  - 737-47
LID - 10.1093/humrep/deq387 [doi]
AB  - BACKGROUND Since prepubertal boys cannot benefit from sperm banking, a potential 
      alternative strategy for fertility preservation involves immature testicular
      tissue (ITT) banking aimed at preservation of spermatogonial stem cells. Survival
      of spermatogonia has been demonstrated after ITT freezing, which is considered
      ethically acceptable. We report the results of a pilot program set up for
      fertility preservation in prepubertal boys. METHODS All boys undergoing ITT
      cryobanking from May 2005 were identified from our clinical register. Data were
      collected from medical files. RESULTS Testicular tissue was retrieved from 52
      prepubertal patients under 12 years of age and 10 peripubertal patients aged
      between 12 and 16 years, in whom no spermatozoa were identified in testicular
      biopsies. Malignant disease accounted for 80.6% of cases; the remaining patients 
      suffered from benign disorders requiring gonadotoxic treatments. Mean ages,
      Tanner stages and occurrence rates of urogenital pathology were 6.43 +/- 3.32 and
      14 +/- 1.23 years, I and I-IV, and 13.5 and 20% for pre- and peripubertal
      patients, respectively. Mean volumes of removed tissue were 20.1 +/- 8.6 and 42.4
      +/- 15.6 mm(3) for pre- and peripubertal patients, respectively. No complications
      occurred during or after tissue retrieval and 93.5% of referred patients accepted
      ITT storage. The presence of spermatogonia, and thus the potential for later
      tissue use, was established in all of these patients. CONCLUSIONS The majority of
      cryopreserved samples showed reproductive potential. Storage was accepted by most
      parents. All parents and children considered this fertility preservation strategy
      a positive approach.
FAU - Wyns, C
AU  - Wyns C
AD  - Department of Gynecology-Andrology, Cliniques Universitaires Saint-Luc,
      Universite Catholique de Louvain, Institut de Recherche Experimentale et
      Clinique, Avenue Hippocrate 10 B-1200, Brussels, Belgium.
FAU - Curaba, M
AU  - Curaba M
FAU - Petit, S
AU  - Petit S
FAU - Vanabelle, B
AU  - Vanabelle B
FAU - Laurent, P
AU  - Laurent P
FAU - Wese, J-F X
AU  - Wese JF
FAU - Donnez, J
AU  - Donnez J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110111
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
SB  - IM
MH  - Belgium
MH  - Biopsy
MH  - Child
MH  - Child, Preschool
MH  - Cryopreservation
MH  - Fertility/*physiology
MH  - Humans
MH  - Infant
MH  - Infertility/pathology
MH  - Male
MH  - Semen Preservation
MH  - Spermatogonia/pathology
MH  - Testis
MH  - Tissue Banks
MH  - Universities
EDAT- 2011/01/14 06:00
MHDA- 2011/07/16 06:00
CRDT- 2011/01/14 06:00
PHST- 2011/01/14 06:00 [entrez]
PHST- 2011/01/14 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
AID - deq387 [pii]
AID - 10.1093/humrep/deq387 [doi]
PST - ppublish
SO  - Hum Reprod. 2011 Apr;26(4):737-47. doi: 10.1093/humrep/deq387. Epub 2011 Jan 11.


PMID- 21227630
OWN - NLM
STAT- MEDLINE
DCOM- 20110615
LR  - 20161209
IS  - 2213-0276 (Electronic)
IS  - 0755-4982 (Linking)
VI  - 40
IP  - 4 Pt 1
DP  - 2011 Apr
TI  - [Refractory sufferings at the end of life: Which considerations, which
      propositions?].
PG  - 341-8
LID - 10.1016/j.lpm.2010.11.012 [doi]
AB  - Refractory suffering of terminally ill people may be physical (pain, dyspnea,
      vomiting...) or existential (spiritual sufferings, anxiousness...). End-of-life
      decisions are often around ethics. Decision making near the end of life consists 
      in witholding and withdrawing life-support treatment and prescribing both of
      treatments with risk of double effect and sedation for distress. In France, such 
      decisions are defined by the deontology code and by the law of April 22nd, 2005
      concerning the end of life and patients' rights. Recommendations from medical
      societies specify the means of implementation: obtaining other medical opinions, 
      the patient's informed consent and full transparency of the decision (noted in
      the patient's medical chart).
CI  - Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
FAU - Joly, Clemence
AU  - Joly C
AD  - CHU Charles-Nicolle, unite regionale de soins palliatifs, 76031 Rouen, France.
      clemence.joly@chu-rouen.fr
FAU - Ghazi Elie, Elisabeth
AU  - Ghazi Elie E
FAU - Maillet, Eric
AU  - Maillet E
FAU - Hannequin, Didier
AU  - Hannequin D
FAU - Guedon, Elisabeth
AU  - Guedon E
LA  - fre
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - Souffrances refractaires en fin de vie : quelles reflexions, quelles propositions
      ?
DEP - 20110111
PL  - France
TA  - Presse Med
JT  - Presse medicale (Paris, France : 1983)
JID - 8302490
RN  - 0 (Anti-Anxiety Agents)
RN  - 0 (Narcotics)
SB  - IM
MH  - Adult
MH  - Advance Care Planning/*ethics/legislation & jurisprudence
MH  - Anti-Anxiety Agents/administration & dosage/adverse effects
MH  - Conscious Sedation/ethics
MH  - Cooperative Behavior
MH  - Ethical Theory
MH  - *Ethics, Medical
MH  - Female
MH  - France
MH  - Humans
MH  - Informed Consent/legislation & jurisprudence
MH  - Interdisciplinary Communication
MH  - Life Support Care/ethics/legislation & jurisprudence
MH  - Medical Futility/ethics/legislation & jurisprudence
MH  - Narcotics/administration & dosage/adverse effects
MH  - *Pain
MH  - Palliative Care/ethics/legislation & jurisprudence
MH  - *Stress, Psychological
MH  - Suicide, Assisted/ethics/legislation & jurisprudence
MH  - Terminal Care/*ethics/legislation & jurisprudence
MH  - Withholding Treatment/*ethics/legislation & jurisprudence
EDAT- 2011/01/14 06:00
MHDA- 2011/06/16 06:00
CRDT- 2011/01/14 06:00
PHST- 2010/10/08 00:00 [received]
PHST- 2010/11/10 00:00 [revised]
PHST- 2010/11/17 00:00 [accepted]
PHST- 2011/01/14 06:00 [entrez]
PHST- 2011/01/14 06:00 [pubmed]
PHST- 2011/06/16 06:00 [medline]
AID - S0755-4982(10)00671-8 [pii]
AID - 10.1016/j.lpm.2010.11.012 [doi]
PST - ppublish
SO  - Presse Med. 2011 Apr;40(4 Pt 1):341-8. doi: 10.1016/j.lpm.2010.11.012. Epub 2011 
      Jan 11.


PMID- 21227555
OWN - NLM
STAT- MEDLINE
DCOM- 20120315
LR  - 20111118
IS  - 1532-3099 (Electronic)
IS  - 0266-6138 (Linking)
VI  - 27
IP  - 6
DP  - 2011 Dec
TI  - Men's involvement in antenatal screening: a qualitative pilot study using e-mail.
PG  - 861-6
LID - 10.1016/j.midw.2010.09.004 [doi]
AB  - OBJECTIVES: This study aimed to explore and analyse men's involvement in
      antenatal genetic screening and testing in England, and evaluate the use of
      e-mail communication as a method of health research with men. DESIGN: After
      receiving a favourable ethical opinion, a longitudinal qualitative pilot study
      was undertaken. PARTICIPANTS: Eight men, whose partners were pregnant, were
      recruited by purposive sampling. FINDINGS: Findings indicated that the men
      experienced ambivalence, doubts and uncertainty about medically identified
      genetic risks, and also experienced an 'emotional rollercoaster', which was
      associated with their involvement in antenatal genetic screening and testing.
      Although connectedness with their partners and shared decision making were highly
      valued, men's involvement was mediated by their partners and health
      professionals, including midwives. CONCLUSIONS AND IMPLICATIONS FOR PRACTICE: The
      implications of findings for medicalisation theory and future research are
      discussed. Using e-mail was a success in that the strong pilot data produced
      provides a stimulus for future research. In addition, implications for policy and
      practice are also considered, specifically the importance of addressing
      ambivalence and mediation if midwives are to communicate effectively when working
      with men and women regarding antenatal genetic screening and testing.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Williams, Robert Alan
AU  - Williams RA
AD  - University of Birmingham, School of Health, and Population Sciences, 52
      Pritchatts Road, Edgbaston, Birmingham B15 2TT, UK. r.a.williams.1@bham.ac.uk
FAU - Dheensa, Sandi
AU  - Dheensa S
FAU - Metcalfe, Alison
AU  - Metcalfe A
LA  - eng
PT  - Journal Article
DEP - 20110111
PL  - Scotland
TA  - Midwifery
JT  - Midwifery
JID - 8510930
MH  - Adult
MH  - *Electronic Mail
MH  - England
MH  - Fathers/*psychology
MH  - Female
MH  - *Genetic Testing
MH  - Health Promotion/methods
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Patient Acceptance of Health Care/psychology
MH  - Pilot Projects
MH  - Pregnancy
MH  - Prenatal Care/psychology
MH  - Prenatal Diagnosis/*psychology
MH  - Spouses/*psychology
MH  - Young Adult
EDAT- 2011/01/14 06:00
MHDA- 2012/03/16 06:00
CRDT- 2011/01/14 06:00
PHST- 2010/04/21 00:00 [received]
PHST- 2010/09/10 00:00 [revised]
PHST- 2010/09/24 00:00 [accepted]
PHST- 2011/01/14 06:00 [entrez]
PHST- 2011/01/14 06:00 [pubmed]
PHST- 2012/03/16 06:00 [medline]
AID - S0266-6138(10)00147-6 [pii]
AID - 10.1016/j.midw.2010.09.004 [doi]
PST - ppublish
SO  - Midwifery. 2011 Dec;27(6):861-6. doi: 10.1016/j.midw.2010.09.004. Epub 2011 Jan
      11.


PMID- 21226970
OWN - NLM
STAT- MEDLINE
DCOM- 20110503
LR  - 20211020
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 12
DP  - 2011 Jan 13
TI  - Collaborative community based care for people and their families living with
      schizophrenia in India: protocol for a randomised controlled trial.
PG  - 12
LID - 10.1186/1745-6215-12-12 [doi]
AB  - BACKGROUND: There is a large treatment gap with few community services for people
      with schizophrenia in low income countries largely due to the shortage of
      specialist mental healthcare human resources. Community based rehabilitation
      (CBR), involving lay health workers, has been shown to be feasible, acceptable
      and more effective than routine care for people with schizophrenia in
      observational studies. The aim of this study is to evaluate whether a lay health 
      worker led, Collaborative Community Based Care (CCBC) intervention, combined with
      usual Facility Based Care (FBC), is superior to FBC alone in improving outcomes
      for people with schizophrenia and their caregivers in India. METHODS/DESIGN: This
      trial is a multi-site, parallel group randomised controlled trial design in
      India.The trial will be conducted concurrently at three sites in India where
      persons with schizophrenia will be screened for eligibility and recruited after
      providing informed consent. Trial participants will be randomly allocated in a
      2:1 ratio to the CCBC+FBC and FBC arms respectively using an allocation sequence 
      pre-prepared through the use of permuted blocks, stratified within site. The
      structured CCBC intervention will be delivered by trained lay community health
      workers (CHWs) working together with the treating Psychiatrist. We aim to recruit
      282 persons with schizophrenia. The primary outcomes are reduction in severity of
      symptoms of schizophrenia and disability at 12 months. The study will be
      conducted according to good ethical practice, data analysis and reporting
      guidelines. DISCUSSION: If the additional CCBC intervention delivered by front
      line CHWs is demonstrated to be effective and cost-effective in comparison to
      usually available care, this intervention can be scaled up to expand coverage and
      improve outcomes for persons with schizophrenia and their caregivers in low
      income countries. TRIAL REGISTRATION: The trial is registered with the
      International Society for the Registration of Clinical Trials and the allocated
      unique ID number is ISRCTN 56877013.
FAU - Chatterjee, Sudipto
AU  - Chatterjee S
AD  - Sangath, Porvorim, Goa, India. sudipto_dr@yahoo.com.au
FAU - Leese, Morven
AU  - Leese M
FAU - Koschorke, Mirja
AU  - Koschorke M
FAU - McCrone, Paul
AU  - McCrone P
FAU - Naik, Smita
AU  - Naik S
FAU - John, Sujit
AU  - John S
FAU - Dabholkar, Hamid
AU  - Dabholkar H
FAU - Goldsmith, Kimberley
AU  - Goldsmith K
FAU - Balaji, Madhumitha
AU  - Balaji M
FAU - Varghese, Mathew
AU  - Varghese M
FAU - Thara, Rangaswamy
AU  - Thara R
FAU - Patel, Vikram
AU  - Patel V
FAU - Thornicroft, Graham
AU  - Thornicroft G
CN  - COmmunity care for People with Schizophrenia in India (COPSI) group
LA  - eng
SI  - ISRCTN/ISRCTN56877013
GR  - 091834/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110113
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
SB  - IM
MH  - Caregivers/*psychology
MH  - *Community Mental Health Services/economics
MH  - *Cooperative Behavior
MH  - Cost-Benefit Analysis
MH  - Developing Countries
MH  - Disability Evaluation
MH  - *Family Relations
MH  - Health Care Costs
MH  - Humans
MH  - India
MH  - *Patient Care Team/economics
MH  - Psychiatric Status Rating Scales
MH  - *Research Design
MH  - Schizophrenia/diagnosis/economics/*therapy
MH  - *Schizophrenic Psychology
MH  - Severity of Illness Index
MH  - Time Factors
MH  - Treatment Outcome
PMC - PMC3033834
EDAT- 2011/01/14 06:00
MHDA- 2011/05/04 06:00
CRDT- 2011/01/14 06:00
PHST- 2010/09/07 00:00 [received]
PHST- 2011/01/13 00:00 [accepted]
PHST- 2011/01/14 06:00 [entrez]
PHST- 2011/01/14 06:00 [pubmed]
PHST- 2011/05/04 06:00 [medline]
AID - 1745-6215-12-12 [pii]
AID - 10.1186/1745-6215-12-12 [doi]
PST - epublish
SO  - Trials. 2011 Jan 13;12:12. doi: 10.1186/1745-6215-12-12.


PMID- 21226735
OWN - NLM
STAT- MEDLINE
DCOM- 20110923
LR  - 20161125
IS  - 1467-9566 (Electronic)
IS  - 0141-9889 (Linking)
VI  - 33
IP  - 4
DP  - 2011 May
TI  - Ethical boundary-work in the infertility clinic.
PG  - 570-85
LID - 10.1111/j.1467-9566.2010.01308.x [doi]
AB  - Infertility practice and reproductive technologies are generally seen as
      'controversial' areas of scientific inquiry that raise many complex ethical
      issues. This paper presents a qualitative study that considered how clinicians
      constructed the role of the 'ethical' in their everyday practice. We use the
      concept of ethical boundary-work to develop a theory of 'settled' and
      'controversial' morality to illuminate how infertility clinicians drew boundaries
      between different conceptions of the role ethics played in their practice. An
      attention to areas of settled morality, usually rendered invisible by their very 
      nature, enables us to see how clinicians manage the 'ethical' in their practice. 
      We argue that by creating a space of 'no-ethics' in their practice--part of a
      settled morality that does not require articulation--the informants
      re-appropriate an area of their practice from 'outside' influences and control.
      Bringing these elements to light can help 'outsiders' to challenge and question
      these distinctions and therefore bring additional perspectives to debates over
      morality in the infertility clinic. Illuminating the everyday ethical concerns of
      infertility clinicians can help direct ethical thinking towards these practical
      concerns, as well as to more abstract debates.
CI  - (c) 2011 The Authors. Sociology of Health & Illness (c) 2011 Foundation for the
      Sociology of Health & Illness/Blackwell Publishing Ltd.
FAU - Frith, Lucy
AU  - Frith L
AD  - Department of Health Service Research, Institute of Psychology, Health and
      Society, University of Liverpool, Liverpool. l.j.frith@liverpool.ac.uk
FAU - Jacoby, Ann
AU  - Jacoby A
FAU - Gabbay, Mark
AU  - Gabbay M
LA  - eng
PT  - Journal Article
DEP - 20110112
PL  - England
TA  - Sociol Health Illn
JT  - Sociology of health & illness
JID - 8205036
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Female
MH  - Humans
MH  - Infertility/therapy
MH  - Interviews as Topic
MH  - Male
MH  - Reproductive Techniques, Assisted/*ethics
MH  - United Kingdom
EDAT- 2011/01/14 06:00
MHDA- 2011/09/29 06:00
CRDT- 2011/01/14 06:00
PHST- 2011/01/14 06:00 [entrez]
PHST- 2011/01/14 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - 10.1111/j.1467-9566.2010.01308.x [doi]
PST - ppublish
SO  - Sociol Health Illn. 2011 May;33(4):570-85. doi: 10.1111/j.1467-9566.2010.01308.x.
      Epub 2011 Jan 12.


PMID- 21195302
OWN - NLM
STAT- MEDLINE
DCOM- 20110527
LR  - 20110103
IS  - 1523-6536 (Electronic)
IS  - 1083-8791 (Linking)
VI  - 17
IP  - 1 Suppl
DP  - 2011 Jan
TI  - Ethical considerations in pediatric BMT donors and recipients.
PG  - S132-6
LID - 10.1016/j.bbmt.2010.11.007 [doi]
FAU - Kamani, Naynesh
AU  - Kamani N
AD  - Children's National Medical Center, Washington, DC 20010, USA. NKamani@cnmc.org
FAU - Lantos, John D
AU  - Lantos JD
FAU - Myers, Doug
AU  - Myers D
FAU - Kahn, Jeffrey P
AU  - Kahn JP
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Biol Blood Marrow Transplant
JT  - Biology of blood and marrow transplantation : journal of the American Society for
      Blood and Marrow Transplantation
JID - 9600628
SB  - IM
MH  - Anemia, Sickle Cell/therapy
MH  - Bone Marrow Transplantation/*ethics
MH  - Child
MH  - Hematologic Diseases/therapy
MH  - Humans
MH  - Risk Assessment/ethics
MH  - Tissue Donors/ethics
EDAT- 2011/01/14 06:00
MHDA- 2011/05/28 06:00
CRDT- 2011/01/04 06:00
PHST- 2011/01/04 06:00 [entrez]
PHST- 2011/01/14 06:00 [pubmed]
PHST- 2011/05/28 06:00 [medline]
AID - S1083-8791(10)00506-9 [pii]
AID - 10.1016/j.bbmt.2010.11.007 [doi]
PST - ppublish
SO  - Biol Blood Marrow Transplant. 2011 Jan;17(1 Suppl):S132-6. doi:
      10.1016/j.bbmt.2010.11.007.


PMID- 21226234
OWN - NLM
STAT- MEDLINE
DCOM- 20110422
LR  - 20110111
IS  - 1466-187X (Electronic)
IS  - 0142-159X (Linking)
VI  - 33
IP  - 1
DP  - 2011
TI  - Humanities and ethics education at Chinese medical schools.
PG  - 87
FAU - Fan, A P
AU  - Fan AP
FAU - Su, T P
AU  - Su TP
FAU - Chen, Y A
AU  - Chen YA
FAU - Chen, C H
AU  - Chen CH
FAU - Lee, C H
AU  - Lee CH
FAU - Tang, W
AU  - Tang W
FAU - Chen, Q
AU  - Chen Q
FAU - Guo, L
AU  - Guo L
FAU - Kosik, R O
AU  - Kosik RO
LA  - eng
PT  - Letter
PL  - England
TA  - Med Teach
JT  - Medical teacher
JID - 7909593
SB  - IM
MH  - China
MH  - Education, Medical, Undergraduate
MH  - Ethics, Medical/*education
MH  - Humanities/*education
MH  - Humans
MH  - *Schools, Medical
EDAT- 2011/01/13 06:00
MHDA- 2011/04/26 06:00
CRDT- 2011/01/13 06:00
PHST- 2011/01/13 06:00 [entrez]
PHST- 2011/01/13 06:00 [pubmed]
PHST- 2011/04/26 06:00 [medline]
PST - ppublish
SO  - Med Teach. 2011;33(1):87.


PMID- 21225240
OWN - NLM
STAT- MEDLINE
DCOM- 20110503
LR  - 20211020
IS  - 1432-1238 (Electronic)
IS  - 0342-4642 (Linking)
VI  - 37
IP  - 2
DP  - 2011 Feb
TI  - Year in review in Intensive Care Medicine 2010: II. Pneumonia and infections,
      cardiovascular and haemodynamics, organization, education, haematology,
      nutrition, ethics and miscellanea.
PG  - 196-213
LID - 10.1007/s00134-010-2123-y [doi]
FAU - Antonelli, Massimo
AU  - Antonelli M
AD  - Department of Intensive Care and Anesthesiology, Policlinico Universitario A.
      Gemelli, Universita Cattolica del Sacro Cuore, Largo A. Gemelli, 8, 00168 Rome,
      Italy. m.antonelli@rm.unicatt.it
FAU - Azoulay, Elie
AU  - Azoulay E
FAU - Bonten, Marc
AU  - Bonten M
FAU - Chastre, Jean
AU  - Chastre J
FAU - Citerio, Giuseppe
AU  - Citerio G
FAU - Conti, Giorgio
AU  - Conti G
FAU - De Backer, Daniel
AU  - De Backer D
FAU - Gerlach, Herwig
AU  - Gerlach H
FAU - Hedenstierna, Goran
AU  - Hedenstierna G
FAU - Joannidis, Michael
AU  - Joannidis M
FAU - Macrae, Duncan
AU  - Macrae D
FAU - Mancebo, Jordi
AU  - Mancebo J
FAU - Maggiore, Salvatore M
AU  - Maggiore SM
FAU - Mebazaa, Alexandre
AU  - Mebazaa A
FAU - Preiser, Jean-Charles
AU  - Preiser JC
FAU - Pugin, Jerome
AU  - Pugin J
FAU - Wernerman, Jan
AU  - Wernerman J
FAU - Zhang, Haibo
AU  - Zhang H
LA  - eng
PT  - Journal Article
DEP - 20110112
PL  - United States
TA  - Intensive Care Med
JT  - Intensive care medicine
JID - 7704851
SB  - IM
MH  - *Cardiac Output
MH  - *Cross Infection/prevention & control
MH  - *Education, Medical, Continuing
MH  - Enteral Nutrition
MH  - *Ethics, Medical
MH  - *Hematology
MH  - *Hemodynamics
MH  - Humans
MH  - *Intensive Care Units/ethics
MH  - *Parenteral Nutrition
MH  - Periodicals as Topic
MH  - *Pneumonia, Ventilator-Associated/drug therapy/prevention & control
PMC - PMC3029678
EDAT- 2011/01/13 06:00
MHDA- 2011/05/04 06:00
CRDT- 2011/01/13 06:00
PHST- 2010/12/27 00:00 [received]
PHST- 2010/12/27 00:00 [accepted]
PHST- 2011/01/13 06:00 [entrez]
PHST- 2011/01/13 06:00 [pubmed]
PHST- 2011/05/04 06:00 [medline]
AID - 10.1007/s00134-010-2123-y [doi]
PST - ppublish
SO  - Intensive Care Med. 2011 Feb;37(2):196-213. doi: 10.1007/s00134-010-2123-y. Epub 
      2011 Jan 12.


PMID- 21224461
OWN - NLM
STAT- MEDLINE
DCOM- 20110113
LR  - 20161125
IS  - 1538-3598 (Electronic)
IS  - 0098-7484 (Linking)
VI  - 305
IP  - 2
DP  - 2011 Jan 12
TI  - Ethical allocation of preexposure HIV prophylaxis.
PG  - 191-2
LID - 10.1001/jama.2010.1975 [doi]
FAU - Gostin, Lawrence O
AU  - Gostin LO
AD  - O'Neill Institute for National and Global Health Law, Georgetown University Law
      Center, 600 New Jersey Ave NW, Washington, DC 20001, USA.
      gostin@law.georgetown.edu
FAU - Kim, Susan C
AU  - Kim SC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - JAMA
JT  - JAMA
JID - 7501160
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - Anti-HIV Agents/*administration & dosage/adverse effects/economics
MH  - Clinical Trials as Topic
MH  - Cost-Benefit Analysis
MH  - Decision Making
MH  - Female
MH  - HIV Infections/*prevention & control
MH  - Health Care Costs
MH  - Health Policy
MH  - Humans
MH  - Male
MH  - Patient Selection/*ethics
MH  - *Policy Making
MH  - Quality of Health Care
MH  - Risk
MH  - Sex Work
MH  - Sexual Behavior
MH  - Substance-Related Disorders
EDAT- 2011/01/13 06:00
MHDA- 2011/01/14 06:00
CRDT- 2011/01/13 06:00
PHST- 2011/01/13 06:00 [entrez]
PHST- 2011/01/13 06:00 [pubmed]
PHST- 2011/01/14 06:00 [medline]
AID - 305/2/191 [pii]
AID - 10.1001/jama.2010.1975 [doi]
PST - ppublish
SO  - JAMA. 2011 Jan 12;305(2):191-2. doi: 10.1001/jama.2010.1975.


PMID- 21224424
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20220317
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 258
IP  - 3
DP  - 2011 Mar
TI  - Diffuse hyperechogenicity of basal ganglia and thalami in preterm neonates: a
      physiologic finding?
PG  - 944-50
LID - 10.1148/radiol.10101086 [doi]
AB  - PURPOSE: To elucidate whether echogenicity (EG) of the basal ganglia and thalami 
      (BGT) represents a physiologic phenomenon in preterm neonates (<32 weeks
      gestation). MATERIALS AND METHODS: The study was approved by the medical ethics
      committee, and informed consent was obtained from the parents. Sequential
      neonatal cranial ultrasonographic (US) images obtained in 130 preterm neonates
      were evaluated for EG of the BGT. In 110 of the 130 neonates, MR imaging was
      performed around or within the first months after term-equivalent age to assess
      myelination and changes in BGT signal. Cranial US studies obtained in 83 low-risk
      near-term neonates were used for comparison. RESULTS: Diffuse homogeneous
      bilateral EG of the BGT was seen in 120 (92%) of 130 preterm neonates and in
      seven (8%) of 83 low-risk neonates (P < .001). In preterm neonates, EG of the BGT
      faded with age and was no longer seen 1 month after delivery. This finding was
      associated with frontal echodensity, which is a normal prematurity-related
      cranial US phenomenon that occurs in the white matter (P < .001). No association 
      with changes on MR images was found. CONCLUSION: In preterm neonates, diffuse
      homogeneous EG of the BGT is a frequent and normal prematurity-related finding.
CI  - (c) RSNA, 2011.
FAU - van Wezel-Meijler, Gerda
AU  - van Wezel-Meijler G
AD  - Department of Pediatrics, Leiden University Medical Center, PO Box 9600, J6-S,
      2300 RC Leiden, The Netherlands. G.van_Wezel-Meijler@lumc.nl
FAU - Leijser, Lara M
AU  - Leijser LM
FAU - Wiggers-de Bruine, Francesca T
AU  - Wiggers-de Bruine FT
FAU - Steggerda, Sylke J
AU  - Steggerda SJ
FAU - van der Grond, Jeroen
AU  - van der Grond J
FAU - Walther, Frans J
AU  - Walther FJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110111
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Basal Ganglia/*diagnostic imaging
MH  - Chi-Square Distribution
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - *Infant, Premature
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Prospective Studies
MH  - Thalamus/*diagnostic imaging
MH  - Ultrasonography
EDAT- 2011/01/13 06:00
MHDA- 2011/06/03 06:00
CRDT- 2011/01/13 06:00
PHST- 2011/01/13 06:00 [entrez]
PHST- 2011/01/13 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
AID - radiol.10101086 [pii]
AID - 10.1148/radiol.10101086 [doi]
PST - ppublish
SO  - Radiology. 2011 Mar;258(3):944-50. doi: 10.1148/radiol.10101086. Epub 2011 Jan
      11.


PMID- 21223616
OWN - NLM
STAT- MEDLINE
DCOM- 20110308
LR  - 20151119
IS  - 1469-2147 (Electronic)
IS  - 0963-1801 (Linking)
VI  - 20
IP  - 1
DP  - 2011 Jan
TI  - MRI research proposals involving child subjects: concerns hindering research
      ethics boards from approving them and a checklist to help evaluate them.
PG  - 115-29
LID - 10.1017/S096318011000068X [doi]
FAU - Shiloff, J Deborah
AU  - Shiloff JD
FAU - Magwood, Bryan
AU  - Magwood B
FAU - Malisza, Krisztina L
AU  - Malisza KL
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Camb Q Healthc Ethics
JT  - Cambridge quarterly of healthcare ethics : CQ : the international journal of
      healthcare ethics committees
JID - 9208482
SB  - IM
MH  - Anxiety/etiology
MH  - Canada
MH  - *Child
MH  - Confidentiality/ethics
MH  - Ethics Committees, Research
MH  - Ethics, Research
MH  - Guidelines as Topic
MH  - Humans
MH  - Incidental Findings
MH  - Informed Consent/*ethics/standards
MH  - Magnetic Resonance Imaging/*adverse effects/*ethics/psychology
MH  - Nontherapeutic Human Experimentation/*ethics
MH  - *Research Subjects
MH  - Risk
MH  - *Surveys and Questionnaires/standards
MH  - United States
EDAT- 2011/01/13 06:00
MHDA- 2011/03/09 06:00
CRDT- 2011/01/13 06:00
PHST- 2011/01/13 06:00 [entrez]
PHST- 2011/01/13 06:00 [pubmed]
PHST- 2011/03/09 06:00 [medline]
AID - S096318011000068X [pii]
AID - 10.1017/S096318011000068X [doi]
PST - ppublish
SO  - Camb Q Healthc Ethics. 2011 Jan;20(1):115-29. doi: 10.1017/S096318011000068X.


PMID- 21223615
OWN - NLM
STAT- MEDLINE
DCOM- 20110308
LR  - 20110112
IS  - 1469-2147 (Electronic)
IS  - 0963-1801 (Linking)
VI  - 20
IP  - 1
DP  - 2011 Jan
TI  - The rapid ethical decisionmaking model: critical medical interventions in
      resource-poor environments.
PG  - 108-14
LID - 10.1017/S0963180110000678 [doi]
FAU - Iserson, Kenneth V
AU  - Iserson KV
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Camb Q Healthc Ethics
JT  - Cambridge quarterly of healthcare ethics : CQ : the international journal of
      healthcare ethics committees
JID - 9208482
SB  - IM
MH  - Algorithms
MH  - Choice Behavior/ethics
MH  - Decision Making/*ethics
MH  - Developing Countries/*economics
MH  - *Health Personnel/ethics/psychology/standards
MH  - *Health Resources
MH  - Humans
MH  - Interpersonal Relations
MH  - Moral Obligations
MH  - *Poverty
MH  - *Social Justice
MH  - Time Factors
EDAT- 2011/01/13 06:00
MHDA- 2011/03/09 06:00
CRDT- 2011/01/13 06:00
PHST- 2011/01/13 06:00 [entrez]
PHST- 2011/01/13 06:00 [pubmed]
PHST- 2011/03/09 06:00 [medline]
AID - S0963180110000678 [pii]
AID - 10.1017/S0963180110000678 [doi]
PST - ppublish
SO  - Camb Q Healthc Ethics. 2011 Jan;20(1):108-14. doi: 10.1017/S0963180110000678.


PMID- 21223608
OWN - NLM
STAT- MEDLINE
DCOM- 20110308
LR  - 20111117
IS  - 1469-2147 (Electronic)
IS  - 0963-1801 (Linking)
VI  - 20
IP  - 1
DP  - 2011 Jan
TI  - Ethical and legal issues in enhancement research on human subjects.
PG  - 30-45
LID - 10.1017/S0963180110000605 [doi]
FAU - Mehlman, Maxwell J
AU  - Mehlman MJ
FAU - Berg, Jessica W
AU  - Berg JW
FAU - Juengst, Eric T
AU  - Juengst ET
FAU - Kodish, Eric
AU  - Kodish E
LA  - eng
GR  - 1 R01 HG003879-01/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Camb Q Healthc Ethics
JT  - Cambridge quarterly of healthcare ethics : CQ : the international journal of
      healthcare ethics committees
JID - 9208482
SB  - IM
MH  - Biomedical Enhancement/*ethics
MH  - Ethics Committees, Research
MH  - Ethics, Research
MH  - Humans
MH  - *Intellectual Disability
MH  - Nontherapeutic Human Experimentation/*ethics
MH  - United States
MH  - *Vulnerable Populations
EDAT- 2011/01/13 06:00
MHDA- 2011/03/09 06:00
CRDT- 2011/01/13 06:00
PHST- 2011/01/13 06:00 [entrez]
PHST- 2011/01/13 06:00 [pubmed]
PHST- 2011/03/09 06:00 [medline]
AID - S0963180110000605 [pii]
AID - 10.1017/S0963180110000605 [doi]
PST - ppublish
SO  - Camb Q Healthc Ethics. 2011 Jan;20(1):30-45. doi: 10.1017/S0963180110000605.


PMID- 21223313
OWN - NLM
STAT- MEDLINE
DCOM- 20110614
LR  - 20110203
IS  - 1532-950X (Electronic)
IS  - 0161-3499 (Linking)
VI  - 40
IP  - 2
DP  - 2011 Feb
TI  - In vitro comparison of mechanical and degradation properties of equivalent
      absorbable suture materials from two different manufacturers.
PG  - 223-7
LID - 10.1111/j.1532-950X.2010.00768.x [doi]
AB  - OBJECTIVE: To compare the mechanical, knotting, and absorption properties of 3
      synthetic absorbable suture materials (polyglactin 910, polydioxanone,
      poliglecaprone 25) from 2 different manufacturers (Huaiyin Medical Instruments
      Co. Ltd. and Ethicon Inc.). SAMPLE POPULATION: Suture material samples from the
      same manufacturing lot for each suture type and manufacturer. METHODS: Part 1: 10
      samples of each suture were incubated in bovine serum and tested for ultimate
      load and stiffness at days 0, 1, 7, 14, 21, and 28. Part 2: 10 knotted samples
      were similarly evaluated, without incubation. RESULTS: Huaiyin polydioxanone had 
      a greater (P<.001) ultimate load on days 0, 1, and 7; and a consistently greater 
      stiffness for the duration of the study, compared with the Ethicon polydioxanone.
      Ethicon poliglecaprone 25 had a greater ultimate load on days 0, 1, 7 (P<.001);
      on day 21 Huaiyin had a greater ultimate load. Ethicon poliglecaprone had greater
      stiffness on days 0, 1, 7 (P<.001). Ethicon polyglactin 910 had a greater
      (P<.001) ultimate load at all times and a greater stiffness (P<.001) at days 0,
      1, 7, and 14 compared with Huaiyin polyglactin 910. Huaiyin polydioxanone and
      polyglactin 910 had greater knot breaking strengths than Ethicon equivalents
      (P<.001). CONCLUSION: Differences in mechanical properties exist between
      nominally identical suture materials from different manufacturers.
CI  - (c) Copyright 2011 by The American College of Veterinary Surgeons.
FAU - de la Puerta, Benito
AU  - de la Puerta B
AD  - North Downs Specialist Referrals, Bletchingley, UK. bpuerta@ndsr.co.uk
FAU - Parsons, Kevin J
AU  - Parsons KJ
FAU - Draper, Edward R C
AU  - Draper ER
FAU - Moores, Alison L
AU  - Moores AL
FAU - Moores, Andrew P
AU  - Moores AP
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110111
PL  - United States
TA  - Vet Surg
JT  - Veterinary surgery : VS
JID - 8113214
RN  - 0 (Dioxanes)
RN  - 0 (Polyesters)
RN  - 31621-87-1 (Polydioxanone)
RN  - 34346-01-5 (Polyglactin 910)
RN  - 41706-81-4 (glycolide E-caprolactone copolymer)
SB  - IM
MH  - Dioxanes/chemistry
MH  - *Materials Testing
MH  - Polydioxanone/chemistry
MH  - Polyesters/chemistry
MH  - Polyglactin 910/chemistry
MH  - *Sutures
MH  - Tensile Strength
MH  - Time Factors
EDAT- 2011/01/13 06:00
MHDA- 2011/06/15 06:00
CRDT- 2011/01/13 06:00
PHST- 2011/01/13 06:00 [entrez]
PHST- 2011/01/13 06:00 [pubmed]
PHST- 2011/06/15 06:00 [medline]
AID - 10.1111/j.1532-950X.2010.00768.x [doi]
PST - ppublish
SO  - Vet Surg. 2011 Feb;40(2):223-7. doi: 10.1111/j.1532-950X.2010.00768.x. Epub 2011 
      Jan 11.


PMID- 21222517
OWN - NLM
STAT- MEDLINE
DCOM- 20110505
LR  - 20121115
IS  - 1939-6376 (Electronic)
IS  - 1939-6368 (Linking)
VI  - 57
IP  - 1-2
DP  - 2011 Feb
TI  - Sperm and testis mediated DNA transfer as a means of gene therapy.
PG  - 35-42
LID - 10.3109/19396368.2010.514022 [doi]
AB  - Assisted reproductive technologies (ART) have revolutionized the treatment of
      infertility. However, many types of infertility may still not be addressable by
      ART. With recent successes in identifying many of the genetic factors responsible
      for male infertility and the future prospect of whole individual human genome
      sequencing to identify disease causing genes, the possible use of gene therapy
      for treating infertility deserves serious consideration. Gene therapy in the
      sperm and testis offers both opportunities and obstacles. The opportunities stem 
      from the fact that numerous different approaches have been developed for
      introducing transgenes into the sperm and testis, mainly because of the interest 
      in using sperm mediated gene transfer and testis mediated gene transfer as ways
      to generate transgenic animals. The obstacles arise from the fact that it may be 
      very difficult to carry out gene therapy of the testis and sperm without also
      affecting the germline. Here we consider new developments in both sperm and
      testis mediated gene transfer, including the use of viral vectors, as well as the
      technical and ethical challenges facing those who would seek to use these
      approaches for gene therapy as a way to treat male infertility.
FAU - Parrington, John
AU  - Parrington J
AD  - Department of Pharmacology, University of Oxford, Oxford, United Kingdom.
      john.parrington@pharm.ox.ac.uk
FAU - Coward, Kevin
AU  - Coward K
FAU - Gadea, Joaquin
AU  - Gadea J
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Syst Biol Reprod Med
JT  - Systems biology in reproductive medicine
JID - 101464963
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Adenoviridae/genetics
MH  - Animals
MH  - Animals, Genetically Modified
MH  - DNA/genetics
MH  - Gene Transfer Techniques/ethics
MH  - Genetic Therapy/methods
MH  - Genetic Vectors
MH  - Humans
MH  - Infertility, Male/genetics/*therapy
MH  - Lentivirus/genetics
MH  - Male
MH  - Reproductive Techniques, Assisted/ethics
MH  - Retroviridae/genetics
MH  - Spermatozoa
MH  - Testis
EDAT- 2011/01/13 06:00
MHDA- 2011/05/06 06:00
CRDT- 2011/01/13 06:00
PHST- 2011/01/13 06:00 [entrez]
PHST- 2011/01/13 06:00 [pubmed]
PHST- 2011/05/06 06:00 [medline]
AID - 10.3109/19396368.2010.514022 [doi]
PST - ppublish
SO  - Syst Biol Reprod Med. 2011 Feb;57(1-2):35-42. doi: 10.3109/19396368.2010.514022.


PMID- 21222188
OWN - NLM
STAT- MEDLINE
DCOM- 20110801
LR  - 20220310
IS  - 1496-8975 (Electronic)
IS  - 0832-610X (Linking)
VI  - 58
IP  - 3
DP  - 2011 Mar
TI  - A prospective cohort study evaluating associations among delirium, postoperative 
      cognitive dysfunction, and apolipoprotein E genotype following open aortic
      repair.
PG  - 246-55
LID - 10.1007/s12630-010-9446-6 [doi]
AB  - BACKGROUND: Patients undergoing major vascular surgery are at high risk of
      postoperative delirium and postoperative cognitive dysfunction (POCD).
      Apolipoprotein E (APOE) is involved in central acetylcholine synthesis, and
      patients bearing the epsilon4 genotype (APOE-epsilon4) are at increased risk of
      both vascular dementia and peripheral vascular disease. The purpose of this study
      was to evaluate the associations among delirium, POCD, and APOE-epsilon4 in
      patients undergoing open aortic repair. METHODS: Following Research Ethics Board 
      approval and written informed consent, we recruited a cohort of patients >/= 60
      yr of age undergoing open aortic repair. Apolipoprotein E genotyping and a
      battery of nine neuropsychometric (NP) tests were performed prior to surgery.
      Delirium was assessed on postoperative days two, four, and discharge using the
      Confusion Assessment Method. Neuropsychometric testing was repeated at discharge 
      and again three months following surgery. A group of non-surgical patients was
      used to adjust NP scores using reliable change index methodology. Logistic
      regression was used to evaluate independent predictors of both delirium and POCD.
      RESULTS: Eighty-eight patients underwent surgery, 78 completed NP testing on
      discharge, and sixty-nine completed NP testing at three months. Delirium was
      noted in 36% of patients after surgery, while POCD was noted in 62% at discharge 
      and 6% at three months. Delirium predicted POCD at discharge (odds ratio 2.86;
      95% confidence intervals 0.99 to 8.27) but not at three months. Apolipoprotein
      E-epsilon4 genotype was not associated with either delirium or POCD following
      adjustment for covariates. CONCLUSION: Both delirium and POCD are common
      following open aortic repair; however, the APOE genotype did not predict either
      condition. This trial has been registered with ClinicalTrials.gov (NCT00911677).
FAU - Bryson, Gregory L
AU  - Bryson GL
AD  - Department of Anesthesiology, The Ottawa Hospital, 1053 Carling Avenue, Box 249C,
      Ottawa, ON K1Y 4E9, Canada. glbryson@ottawahospital.on.ca
FAU - Wyand, Anna
AU  - Wyand A
FAU - Wozny, Denise
AU  - Wozny D
FAU - Rees, Laura
AU  - Rees L
FAU - Taljaard, Monica
AU  - Taljaard M
FAU - Nathan, Howard
AU  - Nathan H
LA  - eng
SI  - ClinicalTrials.gov/NCT00911677
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110111
PL  - United States
TA  - Can J Anaesth
JT  - Canadian journal of anaesthesia = Journal canadien d'anesthesie
JID - 8701709
RN  - 0 (Apolipoprotein E4)
SB  - IM
CIN - Can J Anaesth. 2011 Mar;58(3):233-5, 235-9. PMID: 21194016
MH  - Aged
MH  - Aorta, Abdominal/*surgery
MH  - Apolipoprotein E4/*genetics
MH  - Cognition Disorders/*etiology
MH  - Cohort Studies
MH  - Delirium/*etiology
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Postoperative Complications/*etiology
MH  - Prospective Studies
MH  - Risk
EDAT- 2011/01/12 06:00
MHDA- 2011/08/02 06:00
CRDT- 2011/01/12 06:00
PHST- 2010/04/19 00:00 [received]
PHST- 2010/12/09 00:00 [accepted]
PHST- 2011/01/12 06:00 [entrez]
PHST- 2011/01/12 06:00 [pubmed]
PHST- 2011/08/02 06:00 [medline]
AID - 10.1007/s12630-010-9446-6 [doi]
PST - ppublish
SO  - Can J Anaesth. 2011 Mar;58(3):246-55. doi: 10.1007/s12630-010-9446-6. Epub 2011
      Jan 11.


PMID- 21222122
OWN - NLM
STAT- MEDLINE
DCOM- 20111222
LR  - 20211020
IS  - 1432-2323 (Electronic)
IS  - 0364-2313 (Linking)
VI  - 35
IP  - 8
DP  - 2011 Aug
TI  - The promise of a personalized genomic approach to pancreatic cancer and why
      targeted therapies have missed the mark.
PG  - 1766-9
LID - 10.1007/s00268-010-0949-7 [doi]
AB  - Pancreatic cancer (PC) carries the highest mortality rate of any cancer type.
      Although minor advances in chemotherapy have been made, the mortality rate has
      remained the same over the last several decades. Clinical trials examining
      therapies targeting the epidermal growth factor (EGFR), vascular endothelial
      growth factor (VEGF), specific mutated proteins such as K-ras, immunotherapy
      employing tumor-associated antigens, and biologic therapy such as TNFerade
      (GenVec, Inc., Gaithersburg, MD) have all failed to substantially improve
      survival. Pancreatic cancer is likely a heterogeneous disease; therefore, a
      personalized genomic approach offers the possibility to tailor treatment to the
      unique characteristics of individual patients and their tumors. Rapid advances in
      sequencing technology are decreasing the time and cost of obtaining this
      information to a clinically useful level. However, many challenges remain to be
      faced in applying this technology in the field of PC. Even if patients with PC
      could be identified early in the course of the disease, localizing the disease
      and treating it in a minimally invasive fashion will remain problematic. Ethical 
      issues including patient discrimination and access to care will be particularly
      important in PC. As the field advances, validation, education of clinicians, and 
      determining the true value and source of funding will be difficult. Although the 
      era of personalized genomic medicine has arrived, it will certainly take many
      years to begin to realize its potential. It is to be hoped that this new approach
      will result in a significant improvement in the survival curve for patients with 
      PC.
FAU - Fisher, William E
AU  - Fisher WE
AD  - The Elkins Pancreas Center, Michael E. DeBakey Department of Surgery, Baylor
      College of Medicine, 1709 Dryden, Suite 1500, Houston, TX 77030, USA.
      wfisher@bcm.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Surg
JT  - World journal of surgery
JID - 7704052
RN  - 0 (Antimetabolites, Antineoplastic)
RN  - 0W860991D6 (Deoxycytidine)
RN  - B76N6SBZ8R (gemcitabine)
SB  - IM
CIN - World J Surg. 2011 Sep;35(9):2182-3. PMID: 21409605
MH  - Antimetabolites, Antineoplastic/therapeutic use
MH  - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
MH  - Combined Modality Therapy
MH  - Deoxycytidine/analogs & derivatives/therapeutic use
MH  - Drug Delivery Systems
MH  - Forecasting
MH  - Genetic Association Studies
MH  - Human Genome Project
MH  - Humans
MH  - Molecular Targeted Therapy/*trends
MH  - Pancreatic Neoplasms/*genetics/mortality/*therapy
MH  - Precision Medicine/*trends
MH  - Risk Factors
MH  - Sequence Analysis, DNA
MH  - Survival Rate
MH  - Treatment Failure
EDAT- 2011/01/12 06:00
MHDA- 2011/12/23 06:00
CRDT- 2011/01/12 06:00
PHST- 2011/01/12 06:00 [entrez]
PHST- 2011/01/12 06:00 [pubmed]
PHST- 2011/12/23 06:00 [medline]
AID - 10.1007/s00268-010-0949-7 [doi]
PST - ppublish
SO  - World J Surg. 2011 Aug;35(8):1766-9. doi: 10.1007/s00268-010-0949-7.


PMID- 21222041
OWN - NLM
STAT- MEDLINE
DCOM- 20110323
LR  - 20211020
IS  - 1573-0980 (Electronic)
IS  - 1386-7415 (Linking)
VI  - 32
IP  - 1
DP  - 2011 Feb
TI  - Statistical decisions and the interim analyses of clinical trials.
PG  - 61-74
LID - 10.1007/s11017-010-9170-9 [doi]
AB  - This paper analyzes statistical decisions during the interim analyses of clinical
      trials. After some general remarks about the ethical and scientific demands of
      clinical trials, I introduce the notion of a hard-case clinical trial, explain
      the basic idea behind it, and provide a real example involving the interim
      analyses of zidovudine in asymptomatic HIV-infected patients. The example leads
      me to propose a decision analytic framework for handling ethical conflicts that
      might arise during the monitoring of hard-case clinical trials. I use computer
      simulations to show how the framework can assist in reconciling certain ethical
      conflicts. The framework is partial, lacking the precision of a complete
      systematization of statistical monitoring procedures in practice.
FAU - Stanev, Roger
AU  - Stanev R
AD  - Department of Philosophy, University of British Columbia, 1866 Main Mall E370,
      Vancouver, BC V6T 1Z1, Canada. rstanev@interchange.ubc.ca
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Theor Med Bioeth
JT  - Theoretical medicine and bioethics
JID - 9805378
RN  - 0 (Anti-HIV Agents)
RN  - 4B9XT59T7S (Zidovudine)
SB  - IM
MH  - Anti-HIV Agents/therapeutic use
MH  - Bayes Theorem
MH  - Clinical Trials as Topic/*ethics/*methods/trends
MH  - *Data Interpretation, Statistical
MH  - Decision Making/*ethics
MH  - HIV Infections/drug therapy
MH  - Humans
MH  - Mathematical Computing
MH  - Multicenter Studies as Topic/ethics/methods
MH  - Research Design/*trends
MH  - Statistics as Topic/methods
MH  - Zidovudine/therapeutic use
EDAT- 2011/01/12 06:00
MHDA- 2011/03/24 06:00
CRDT- 2011/01/12 06:00
PHST- 2011/01/12 06:00 [entrez]
PHST- 2011/01/12 06:00 [pubmed]
PHST- 2011/03/24 06:00 [medline]
AID - 10.1007/s11017-010-9170-9 [doi]
PST - ppublish
SO  - Theor Med Bioeth. 2011 Feb;32(1):61-74. doi: 10.1007/s11017-010-9170-9.


PMID- 21222008
OWN - NLM
STAT- MEDLINE
DCOM- 20111209
LR  - 20211020
IS  - 1248-9204 (Electronic)
IS  - 1248-9204 (Linking)
VI  - 15
IP  - 3
DP  - 2011 Jun
TI  - The design of an industry-sponsored randomized controlled trial to compare
      synthetic mesh versus biologic mesh for inguinal hernia repair.
PG  - 325-32
LID - 10.1007/s10029-010-0773-x [doi]
AB  - PURPOSE: Biologic prostheses are designed to support tissue regeneration rather
      than just result in a strong scar plate, as is the case with synthetic mesh. It
      is not known if these newer materials will result in earlier return to normal
      activities and/or less post-herniorrhaphy groin pain. METHOD/STUDY DESIGN: A
      prospective, randomized, controlled, third-party-blinded multicenter trial was
      designed to compare the use of a non-cross linked porcine dermis biologic graft
      [Strattice(TM) Reconstructive Tissue Matrix (RTM), LifeCell, Branchburg, NJ]
      versus light weight, large pore polypropylene mesh (UltraPro(TM), Ethicon,
      Somerville, NJ). The study design called for recruitment of 170 men. These men
      are being followed for a minimum of 2 years. The primary aim of this study is to 
      compare the safety and effectiveness of the two materials in a Lichtenstein
      inguinal hernia repair as measured by resumption of activities of daily living.
      Secondary outcomes include chronic pain, postoperative complications and the
      incidence of re-herniation at 12 and 24 months. RESULTS: This paper discusses the
      study design, patient recruitment and the current status of the clinical trial.
      The study involves nine medical centers, all with extensive experience in hernia 
      repair. After 24 months of enrollment, 172 men were randomized and recruitment
      was then closed. All patients underwent elective repair of primary unilateral
      inguinal hernias as an outpatient operation. Follow up data are being collected. 
      Data analyses are scheduled at 3, 12, and 24 months postoperatively. CONCLUSION: 
      We report the design of a multi-center, third-party blinded, randomized clinical 
      trial comparing a new surgical device with existing technology in the repair of
      inguinal hernias. We believe this investigator-designed and conducted trial could
      serve as a model for similar trials examining surgical devices performed in
      collaboration with industry.
FAU - Bellows, C F
AU  - Bellows CF
AD  - Department of Surgery SL-22, Tulane University Health Sciences Center, 1430
      Tulane Ave., New Orleans, LA 70115, USA. cbellows@tulane.edu
FAU - Shadduck, P P
AU  - Shadduck PP
FAU - Helton, W S
AU  - Helton WS
FAU - Fitzgibbons, R J
AU  - Fitzgibbons RJ
LA  - eng
SI  - ClinicalTrials.gov/NCT00681291
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110108
PL  - France
TA  - Hernia
JT  - Hernia : the journal of hernias and abdominal wall surgery
JID - 9715168
RN  - 0 (Biocompatible Materials)
RN  - 0 (Polypropylenes)
RN  - 0 (strattice)
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Activities of Daily Living
MH  - Biocompatible Materials/adverse effects/*therapeutic use
MH  - Collagen/adverse effects/*therapeutic use
MH  - Hernia, Inguinal/*surgery
MH  - Humans
MH  - Male
MH  - Pain
MH  - Polypropylenes/adverse effects/*therapeutic use
MH  - *Postoperative Complications
MH  - Recurrence
MH  - *Research Design
MH  - Surgical Mesh/*adverse effects
MH  - Tissue Scaffolds/adverse effects
EDAT- 2011/01/12 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/01/12 06:00
PHST- 2010/11/02 00:00 [received]
PHST- 2010/12/17 00:00 [accepted]
PHST- 2011/01/12 06:00 [entrez]
PHST- 2011/01/12 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 10.1007/s10029-010-0773-x [doi]
PST - ppublish
SO  - Hernia. 2011 Jun;15(3):325-32. doi: 10.1007/s10029-010-0773-x. Epub 2011 Jan 8.


PMID- 21221769
OWN - NLM
STAT- MEDLINE
DCOM- 20120914
LR  - 20151119
IS  - 1573-7217 (Electronic)
IS  - 0167-6806 (Linking)
VI  - 130
IP  - 1
DP  - 2011 Nov
TI  - Prognostic significance of methylated RASSF1A and PITX2 genes in blood- and bone 
      marrow plasma of breast cancer patients.
PG  - 109-17
LID - 10.1007/s10549-010-1335-8 [doi]
AB  - Free circulating DNA is increased in the serum/plasma of cancer patients, and
      methylation of certain genes has been found to be characteristic for malignancy. 
      Therefore, we investigated the prognostic value of two promising genes, PITX2 and
      RASSF1A, in peripheral blood-plasma (PB-P) and bone marrow plasma (BM-P) of
      breast cancer patients. Peripheral blood and bone marrow samples from patients
      with primary breast cancer were prospectively collected during primary surgery at
      the Department of Obstetrics and Gynecology in Innsbruck (n = 428) from June 2000
      to December 2006. The study has been approved by the ethical committee of the
      Medical University of Innsbruck. Methylation analysis was performed using
      MethyLight, a methylation-specific quantitative PCR-method. In univariate
      survival analysis, methylated PITX2 in PB-P was found to be a significant
      indicator for poor overall survival (OAS) and distant disease-free survival
      (DDFS) (P = 0.001 and P = 0.023). Methylated RASSF1A in PB-P was also an
      indicator for poor OAS and DDFS (P = 0.001 and P = 0.004). RASSF1A had also
      significant prognostic potential when determined in BM-P (P = 0.016). In
      multivariate survival analysis methylated PITX2 and RASSF1A in PB-P remained as
      therapy-independent prognostic factors for OAS (P = 0.021, P < 0.001). For DDFS
      only RASSF1A in PB-P showed prognostic significance (P = 0.002). Methylated
      RASSF1A and PITX2 in PB-P appear to have promising potential as prognostic
      markers in clinical use.
FAU - Gobel, Georg
AU  - Gobel G
AD  - Department of Medical Statistics, Informatics and Health Economics, Innsbruck
      Medical University, Innsbruck, Austria.
FAU - Auer, Doris
AU  - Auer D
FAU - Gaugg, Inge
AU  - Gaugg I
FAU - Schneitter, Alois
AU  - Schneitter A
FAU - Lesche, Ralf
AU  - Lesche R
FAU - Muller-Holzner, Elisabeth
AU  - Muller-Holzner E
FAU - Marth, Christian
AU  - Marth C
FAU - Daxenbichler, Gunter
AU  - Daxenbichler G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110108
PL  - Netherlands
TA  - Breast Cancer Res Treat
JT  - Breast cancer research and treatment
JID - 8111104
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (DNA, Neoplasm)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (RASSF1 protein, human)
RN  - 0 (Transcription Factors)
RN  - 0 (Tumor Suppressor Proteins)
RN  - 184787-43-7 (homeobox protein PITX2)
SB  - IM
CIN - Breast Cancer Res Treat. 2011 Nov;130(1):119-22. PMID: 21327462
MH  - Aged
MH  - Biomarkers, Tumor/*blood/genetics
MH  - Bone Marrow/metabolism
MH  - Breast Neoplasms/*diagnosis/*genetics/mortality
MH  - *DNA Methylation
MH  - DNA, Neoplasm/*blood
MH  - Female
MH  - Homeodomain Proteins/*genetics
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Middle Aged
MH  - Neoplastic Cells, Circulating/metabolism
MH  - Prognosis
MH  - Transcription Factors/*genetics
MH  - Tumor Suppressor Proteins/*genetics
EDAT- 2011/01/12 06:00
MHDA- 2012/09/15 06:00
CRDT- 2011/01/12 06:00
PHST- 2008/11/14 00:00 [received]
PHST- 2010/12/23 00:00 [accepted]
PHST- 2011/01/12 06:00 [entrez]
PHST- 2011/01/12 06:00 [pubmed]
PHST- 2012/09/15 06:00 [medline]
AID - 10.1007/s10549-010-1335-8 [doi]
PST - ppublish
SO  - Breast Cancer Res Treat. 2011 Nov;130(1):109-17. doi: 10.1007/s10549-010-1335-8. 
      Epub 2011 Jan 8.


PMID- 21220723
OWN - NLM
STAT- MEDLINE
DCOM- 20110209
LR  - 20211020
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Linking)
VI  - 76
IP  - 2
DP  - 2011 Jan 11
TI  - Rethinking the thinking cap: ethics of neural enhancement using noninvasive brain
      stimulation.
PG  - 187-93
LID - 10.1212/WNL.0b013e318205d50d [doi]
AB  - Although a growing body of evidence suggests that noninvasive brain stimulation
      techniques such as transcranial magnetic stimulation and transcranial direct
      current stimulation have the capacity to enhance neural function in both
      brain-injured and neurally intact individuals, the implications of their
      potential use for cosmetic self-enhancement have not been fully explored. We
      review 3 areas in which noninvasive brain stimulation has the potential to
      enhance neurologic function: cognitive skills, mood, and social cognition. We
      then characterize the ethical problems that affect the practice of cosmetic
      neurology, including safety, character, justice, and autonomy, and discuss how
      these problems may apply to the use of noninvasive brain stimulation for
      self-enhancement.
FAU - Hamilton, Roy
AU  - Hamilton R
AD  - Department of Neurology, University of Pennsylvania, Philadelphia, USA.
      royhhamilton@yahoo.com
FAU - Messing, Samuel
AU  - Messing S
FAU - Chatterjee, Anjan
AU  - Chatterjee A
LA  - eng
GR  - 1K01NS060995/NS/NINDS NIH HHS/United States
GR  - R01 DC004817/DC/NIDCD NIH HHS/United States
GR  - R01 DC008779/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
SB  - IM
MH  - *Affect
MH  - Biomedical Enhancement/*ethics/methods
MH  - *Cognition
MH  - Electric Stimulation Therapy/*ethics
MH  - Humans
MH  - Individuality
MH  - *Social Behavior
MH  - Transcranial Magnetic Stimulation/*ethics
PMC - PMC3030230
EDAT- 2011/01/12 06:00
MHDA- 2011/02/10 06:00
CRDT- 2011/01/12 06:00
PHST- 2011/01/12 06:00 [entrez]
PHST- 2011/01/12 06:00 [pubmed]
PHST- 2011/02/10 06:00 [medline]
AID - 76/2/187 [pii]
AID - 10.1212/WNL.0b013e318205d50d [doi]
PST - ppublish
SO  - Neurology. 2011 Jan 11;76(2):187-93. doi: 10.1212/WNL.0b013e318205d50d.


PMID- 21220607
OWN - NLM
STAT- MEDLINE
DCOM- 20110506
LR  - 20110301
IS  - 1527-7755 (Electronic)
IS  - 0732-183X (Linking)
VI  - 29
IP  - 7
DP  - 2011 Mar 1
TI  - Wheatgrass in Afifi's garden: sprouting integrative oncology collaborations in
      the Middle East.
PG  - 944-6
LID - 10.1200/JCO.2010.33.4532 [doi]
AB  - We suggest that bridging traditional and modern medicine can in many cases
      empower patients and enable them to better cope with cancer treatment. Our
      experiences in the Middle East might be applicable to other areas of the world
      facing a similar need to integrate evidence-based medicine with narrative-based, 
      ethics-based, and ethnic medicine in the practice of oncology. In addition,we
      hope that our common efforts will encourage future collaboration among scientists
      and clinicians in the Middle East, which in turn might promote understanding,
      tolerance, and mutual respect among professionals in an area of the world
      troubled by ongoing geopolitical conflict.
FAU - Ben-Arye, Eran
AU  - Ben-Arye E
AD  - Lin Medical Center, Clalit Health Services; Technion-Israel Institute of
      Technology, Israel. eranben@netvision.net.il
FAU - Schiff, Elad
AU  - Schiff E
FAU - Steiner, Mariana
AU  - Steiner M
FAU - Silbermann, Michael
AU  - Silbermann M
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20110110
PL  - United States
TA  - J Clin Oncol
JT  - Journal of clinical oncology : official journal of the American Society of
      Clinical Oncology
JID - 8309333
SB  - IM
MH  - Adenocarcinoma/pathology/therapy
MH  - *Agropyron
MH  - Antineoplastic Combined Chemotherapy Protocols/*administration & dosage/adverse
      effects
MH  - Chemotherapy, Adjuvant
MH  - Combined Modality Therapy
MH  - Complementary Therapies/*methods
MH  - Female
MH  - Gastrectomy/methods
MH  - Humans
MH  - Integrative Medicine/*methods
MH  - Israel
MH  - Middle Aged
MH  - Middle East
MH  - Neoplasm Staging
MH  - Phytotherapy/methods
MH  - *Quality of Life
MH  - Referral and Consultation
MH  - Stomach Neoplasms/pathology/therapy
MH  - Treatment Outcome
EDAT- 2011/01/12 06:00
MHDA- 2011/05/07 06:00
CRDT- 2011/01/12 06:00
PHST- 2011/01/12 06:00 [entrez]
PHST- 2011/01/12 06:00 [pubmed]
PHST- 2011/05/07 06:00 [medline]
AID - JCO.2010.33.4532 [pii]
AID - 10.1200/JCO.2010.33.4532 [doi]
PST - ppublish
SO  - J Clin Oncol. 2011 Mar 1;29(7):944-6. doi: 10.1200/JCO.2010.33.4532. Epub 2011
      Jan 10.


PMID- 21220568
OWN - NLM
STAT- MEDLINE
DCOM- 20110502
LR  - 20110111
IS  - 1552-7409 (Electronic)
IS  - 0894-3184 (Linking)
VI  - 24
IP  - 1
DP  - 2011 Jan
TI  - Human dignity: scenarios with doing the right thing.
PG  - 16-9
LID - 10.1177/0894318410389077 [doi]
AB  - Human dignity is a phenomenon of great importance to all health-related
      disciplines. For the professional nurse, human dignity is embedded in the
      ontological beliefs of a philosophical school of thought that guides the priority
      actions found in nurse practice. The common ethical phrase of doing the right
      thing is insinuated in the enduring truths of affirming human dignity in nurse
      practice. The author in this column examines possible meanings for doing the
      right thing in light of the ethical tenets of humanbecoming including reverence, 
      awe, betrayal, and shame.
FAU - Milton, Constance L
AU  - Milton CL
AD  - California Baptist University, Riverside, CA 92504, USA.
      constancemilton@yahoo.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Nurs Sci Q
JT  - Nursing science quarterly
JID - 8805022
MH  - Humans
MH  - Nursing
MH  - *Personhood
EDAT- 2011/01/12 06:00
MHDA- 2011/05/03 06:00
CRDT- 2011/01/12 06:00
PHST- 2011/01/12 06:00 [entrez]
PHST- 2011/01/12 06:00 [pubmed]
PHST- 2011/05/03 06:00 [medline]
AID - 24/1/16 [pii]
AID - 10.1177/0894318410389077 [doi]
PST - ppublish
SO  - Nurs Sci Q. 2011 Jan;24(1):16-9. doi: 10.1177/0894318410389077.


PMID- 21220521
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20110209
IS  - 1744-5019 (Electronic)
IS  - 0360-5310 (Linking)
VI  - 36
IP  - 1
DP  - 2011 Feb
TI  - Arboriculture in clinical ethics: using philosophical critical appraisal to clear
      away underbrush in ethical analysis and argument.
PG  - 1-5
LID - 10.1093/jmp/jhq060 [doi]
AB  - This paper introduces the 2011 number of the Journal on Clinical Ethics.
      Philosophical critical appraisal is essential for the success of philosophical
      analysis and argument in clinical ethics. To clear away conceptual underbrush,
      papers in this Clinical Ethics number of the Journal address genetic engineering,
      conscience-based objections to forms of health care, placebos, and preventing
      exploitation of patients to be recruited to become research subjects.
FAU - McCullough, Laurence B
AU  - McCullough LB
AD  - Center for Medical Ethics and Health Policy, Baylor College of Medicine, One
      Baylor Plaza MS 420, Houston, TX 77030, USA. mccullou@bcm.edu
LA  - eng
PT  - Introductory Journal Article
DEP - 20110110
PL  - United States
TA  - J Med Philos
JT  - The Journal of medicine and philosophy
JID - 7610512
RN  - 0 (Placebos)
SB  - IM
MH  - Conscience
MH  - *Ethical Analysis
MH  - *Ethics, Clinical
MH  - Genetic Engineering/ethics
MH  - Humans
MH  - Patient Selection/ethics
MH  - *Philosophy, Medical
MH  - Placebos
EDAT- 2011/01/12 06:00
MHDA- 2011/06/03 06:00
CRDT- 2011/01/12 06:00
PHST- 2011/01/12 06:00 [entrez]
PHST- 2011/01/12 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
AID - jhq060 [pii]
AID - 10.1093/jmp/jhq060 [doi]
PST - ppublish
SO  - J Med Philos. 2011 Feb;36(1):1-5. doi: 10.1093/jmp/jhq060. Epub 2011 Jan 10.


PMID- 21220283
OWN - NLM
STAT- MEDLINE
DCOM- 20110317
LR  - 20151119
IS  - 1364-503X (Print)
IS  - 1364-503X (Linking)
VI  - 369
IP  - 1936
DP  - 2011 Feb 13
TI  - The search for life in our Solar System and the implications for science and
      society.
PG  - 594-606
LID - 10.1098/rsta.2010.0247 [doi]
AB  - The search for another type of life in the Solar System addresses the fundamental
      question of life in the Universe. To determine if life forms we discover
      represent a second genesis, we must find biological material that would allow us 
      to compare that life to the Earth's phylogenetic tree of life. An organism would 
      be alien if, and only if, it did not link to our tree of life. In our Solar
      System, the worlds of interest for a search for life are Mars, Europa, Enceladus 
      and, for biochemistry based on a liquid other than water, Titan. If we find
      evidence for a second genesis of life, we will certainly learn from the
      comparative study of the biochemistry, organismal biology and ecology of the
      alien life. The discovery of alien life, if alive or revivable, will pose
      fundamentally new questions in environmental ethics. We should plan our
      exploration strategy such that we conduct biologically reversible exploration. In
      the long term we would do well, ethically and scientifically, to strive to
      support any alien life discovered as part of an overall commitment to enhancing
      the richness and diversity of life in the Universe.
FAU - McKay, Christopher P
AU  - McKay CP
AD  - Space Science Division, NASA Ames Research Center, Moffett Field, CA 94035, USA. 
      chris.mckay@nasa.gov
LA  - eng
PT  - Journal Article
PL  - England
TA  - Philos Trans A Math Phys Eng Sci
JT  - Philosophical transactions. Series A, Mathematical, physical, and engineering
      sciences
JID - 101133385
SB  - IM
MH  - Exobiology/ethics/*methods
MH  - *Extraterrestrial Environment
MH  - Origin of Life
MH  - *Science
MH  - *Social Values
MH  - *Solar System
EDAT- 2011/01/12 06:00
MHDA- 2011/03/18 06:00
CRDT- 2011/01/12 06:00
PHST- 2011/01/12 06:00 [entrez]
PHST- 2011/01/12 06:00 [pubmed]
PHST- 2011/03/18 06:00 [medline]
AID - 369/1936/594 [pii]
AID - 10.1098/rsta.2010.0247 [doi]
PST - ppublish
SO  - Philos Trans A Math Phys Eng Sci. 2011 Feb 13;369(1936):594-606. doi:
      10.1098/rsta.2010.0247.


PMID- 21219853
OWN - NLM
STAT- MEDLINE
DCOM- 20110406
LR  - 20220331
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 405
IP  - 3
DP  - 2011 Feb 18
TI  - The epigenetic effect of glucosamine and a nuclear factor-kappa B (NF-kB)
      inhibitor on primary human chondrocytes--implications for osteoarthritis.
PG  - 362-7
LID - 10.1016/j.bbrc.2011.01.007 [doi]
AB  - OBJECTIVE: Idiopathic osteoarthritis is the most common form of osteoarthritis
      (OA) world-wide and remains the leading cause of disability and the associated
      socio-economic burden in an increasing aging population. Traditionally, OA has
      been viewed as a degenerative joint disease characterized by progressive
      destruction of the articular cartilage and changes in the subchondral bone
      culminating in joint failure. However, the etiology of OA is multifactorial
      involving genetic, mechanical and environmental factors. Treatment modalities
      include analgesia, joint injection with steroids or hyaluronic acid, oral
      supplements including glucosamine and chondroitin sulfate, as well as
      physiotherapy. Thus, there is significant interest in the discovery of disease
      modifying agents. One such agent, glucosamine (GlcN) is commonly prescribed even 
      though the therapeutic efficacy and mechanism of action remain controversial.
      Inflammatory cytokines, including IL-1beta, and proteinases such as MMP-13 have
      been implicated in the pathogenesis and progression of OA together with an
      associated CpG demethylation in their promoters. We have investigated the
      potential of GlcN to modulate NF-kB activity and cytokine-induced abnormal gene
      expression in articular chondrocytes and, critically, whether this is associated 
      with an epigenetic process. METHOD: Human chondrocytes were isolated from the
      articular cartilage of femoral heads, obtained with ethical permission, following
      fractured neck of femur surgery. Chondrocytes were cultured for 5 weeks in six
      separate groups; (i) control culture, (ii) cultured with a mixture of 2.5 ng/ml
      IL-1beta and 2.5 ng/ml oncostatin M (OSM), (iii) cultured with 2mM N-acetyl GlcN 
      (Sigma-Aldrich), (iv) cultured with a mixture of 2.5 ng/ml IL-1beta, 2.5 ng/ml
      OSM and 2mM GlcN, (v) cultured with 1.0 muM BAY 11-7082 (BAY; NF-kB inhibitor:
      Calbiochem, Darmstadt, Germany) and, (vi) cultured with a mixture of 2.5 ng/ml
      IL-1beta, 2.5 ng/ml OSM and 1.0 muM BAY. The levels of IL1B and MMP13 mRNA were
      examined using qRT-PCR. The percentage DNA methylation in the CpG sites of the
      IL1beta and MMP13 proximal promoter were quantified by pyrosequencing. RESULT:
      IL1beta expression was enhanced over 580-fold in articular chondrocytes treated
      with IL-1beta and OSM. GlcN dramatically ameliorated the cytokine-induced
      expression by 4-fold. BAY alone increased IL1beta expression by 3-fold. In the
      presence of BAY, IL-1beta induced IL1B mRNA levels were decreased by 6-fold. The 
      observed average percentage methylation of the -256 CpG site in the IL1beta
      promoter was 65% in control cultures and decreased to 36% in the presence of
      IL-1beta/OSM. GlcN and BAY alone had a negligible effect on the methylation
      status of the IL1B promoter. The cytokine-induced loss of methylation status in
      the IL1B promoter was ameliorated by both GlcN and BAY to 44% and 53%,
      respectively. IL-1beta/OSM treatment increased MMP13 mRNA levels independently of
      either GlcN or BAY and no change in the methylation status of the MMP13 promoter 
      was observed. CONCLUSION: We demonstrate for the first time that GlcN and BAY can
      prevent cytokine-induced demethylation of a specific CpG site in the IL1beta
      promoter and this was associated with decreased expression of IL1beta. These
      studies provide a potential mechanism of action for OA disease modifying agents
      via NF-kB and, critically, demonstrate the need for further studies to elucidate 
      the role that NF-kB may play in DNA demethylation in human chondrocytes.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Imagawa, Kei
AU  - Imagawa K
AD  - University of Southampton Medical School, Bone and Joint Research Group,
      Southampton, UK. k.Imagawa@soton.ac.uk
FAU - de Andres, M C
AU  - de Andres MC
FAU - Hashimoto, Ko
AU  - Hashimoto K
FAU - Pitt, Dominic
AU  - Pitt D
FAU - Itoi, Eiji
AU  - Itoi E
FAU - Goldring, Mary B
AU  - Goldring MB
FAU - Roach, Helmtrud I
AU  - Roach HI
FAU - Oreffo, Richard O C
AU  - Oreffo RO
LA  - eng
GR  - R01 AG022021-09/AG/NIA NIH HHS/United States
GR  - R21-AR054887/AR/NIAMS NIH HHS/United States
GR  - RC4 AR060546/AR/NIAMS NIH HHS/United States
GR  - RC4 AR060546-01/AR/NIAMS NIH HHS/United States
GR  - R01-AG022021/AG/NIA NIH HHS/United States
GR  - G006970/1/BB_/Biotechnology and Biological Sciences Research Council/United
      Kingdom
GR  - R01 AG022021-08/AG/NIA NIH HHS/United States
GR  - R01 AG022021/AG/NIA NIH HHS/United States
GR  - R21 AR054887-02/AR/NIAMS NIH HHS/United States
GR  - R21 AR054887/AR/NIAMS NIH HHS/United States
GR  - BB/G010579/1/BB_/Biotechnology and Biological Sciences Research Council/United
      Kingdom
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110108
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (3-(4-methylphenylsulfonyl)-2-propenenitrile)
RN  - 0 (Interleukin-1beta)
RN  - 0 (NF-kappa B)
RN  - 0 (Nitriles)
RN  - 0 (Sulfones)
RN  - EC 2.1.1.37 (DNA (Cytosine-5-)-Methyltransferase 1)
RN  - EC 2.1.1.37 (DNA (Cytosine-5-)-Methyltransferases)
RN  - EC 3.4.24.- (Matrix Metalloproteinase 13)
RN  - N08U5BOQ1K (Glucosamine)
SB  - IM
MH  - Cells, Cultured
MH  - Chondrocytes/*drug effects
MH  - DNA (Cytosine-5-)-Methyltransferase 1
MH  - DNA (Cytosine-5-)-Methyltransferases/antagonists &
      inhibitors/biosynthesis/genetics
MH  - DNA Methylation/drug effects
MH  - Down-Regulation
MH  - Epigenesis, Genetic/*drug effects
MH  - Glucosamine/*pharmacology
MH  - Humans
MH  - Interleukin-1beta/genetics/metabolism
MH  - Matrix Metalloproteinase 13/genetics/metabolism
MH  - NF-kappa B/*antagonists & inhibitors
MH  - Nitriles/*pharmacology
MH  - Osteoarthritis/genetics/*metabolism
MH  - Promoter Regions, Genetic/drug effects
MH  - Sulfones/*pharmacology
PMC - PMC3937866
MID - NIHMS349843
EDAT- 2011/01/12 06:00
MHDA- 2011/04/07 06:00
CRDT- 2011/01/12 06:00
PHST- 2010/12/30 00:00 [received]
PHST- 2011/01/04 00:00 [accepted]
PHST- 2011/01/12 06:00 [entrez]
PHST- 2011/01/12 06:00 [pubmed]
PHST- 2011/04/07 06:00 [medline]
AID - S0006-291X(11)00017-9 [pii]
AID - 10.1016/j.bbrc.2011.01.007 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2011 Feb 18;405(3):362-7. doi:
      10.1016/j.bbrc.2011.01.007. Epub 2011 Jan 8.


PMID- 21219672
OWN - NLM
STAT- MEDLINE
DCOM- 20110422
LR  - 20220317
IS  - 1815-7920 (Electronic)
IS  - 1027-3719 (Linking)
VI  - 15
IP  - 2
DP  - 2011 Feb
TI  - The Union and Medecins Sans Frontieres approach to operational research.
PG  - 144-54, i
AB  - Operational research (OR) has become a hot topic at national meetings,
      international conferences and donor fora. The International Union Against
      Tuberculosis and Lung Disease (The Union) and Medecins Sans Frontieres (MSF)
      Operational Centre Brussels strongly promote and implement OR with colleagues in 
      low- and middle-income countries. Here we describe how the two organisations
      define OR, and explain the guiding principles and methodology that underpin the
      strategy for developing and expanding OR in those countries. We articulate The
      Union's and MSF's approach to supporting OR, highlighting the main synergies and 
      differences. Then, using the Malawi National Tuberculosis Control Programme as an
      example, we show how OR can be embedded within tuberculosis control activities,
      leading to changes in policy and practice at the national level. We discuss the
      difficult, yet vitally important, issue of capacity building, and share our
      vision of a new paradigm of product-related training and performance-based OR
      fellowships as two ways of developing the necessary skills at country level to
      ensure research is actually performed. Finally, we highlight the need to consider
      and incorporate into practice the ethical components of OR. This is a key moment 
      to be involved in OR. We are confident that in partnership with interested
      stakeholders, including the World Health Organization, we can stimulate the
      implementation of quality, relevant OR as an integral part of health service
      delivery that in turn will lead to better health for people, particularly for
      those living in the poorer parts of the world.
FAU - Harries, A D
AU  - Harries AD
AD  - International Union Against Tuberculosis and Lung Disease, Paris, France.
      adharries@theunion.org
FAU - Rusen, I D
AU  - Rusen ID
FAU - Reid, T
AU  - Reid T
FAU - Detjen, A K
AU  - Detjen AK
FAU - Berger, S D
AU  - Berger SD
FAU - Bissell, K
AU  - Bissell K
FAU - Hinderaker, S G
AU  - Hinderaker SG
FAU - Edginton, M
AU  - Edginton M
FAU - Fussell, M
AU  - Fussell M
FAU - Fujiwara, P I
AU  - Fujiwara PI
FAU - Zachariah, R
AU  - Zachariah R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - Int J Tuberc Lung Dis
JT  - The international journal of tuberculosis and lung disease : the official journal
      of the International Union against Tuberculosis and Lung Disease
JID - 9706389
SB  - IM
MH  - *Cooperative Behavior
MH  - Developing Countries
MH  - Guidelines as Topic
MH  - Humans
MH  - *Interinstitutional Relations
MH  - Malawi/epidemiology
MH  - Medical Missions/ethics/*organization & administration
MH  - National Health Programs
MH  - *Operations Research
MH  - Organizational Objectives
MH  - Program Development
MH  - Relief Work/ethics/*organization & administration
MH  - Terminology as Topic
MH  - Tuberculosis/epidemiology/*prevention & control
MH  - Voluntary Health Agencies/ethics/*organization & administration
MH  - World Health Organization
EDAT- 2011/01/12 06:00
MHDA- 2011/04/26 06:00
CRDT- 2011/01/12 06:00
PHST- 2011/01/12 06:00 [entrez]
PHST- 2011/01/12 06:00 [pubmed]
PHST- 2011/04/26 06:00 [medline]
PST - ppublish
SO  - Int J Tuberc Lung Dis. 2011 Feb;15(2):144-54, i.


PMID- 21219642
OWN - NLM
STAT- MEDLINE
DCOM- 20110524
LR  - 20211020
IS  - 1746-160X (Electronic)
IS  - 1746-160X (Linking)
VI  - 7
DP  - 2011 Jan 10
TI  - Gingival crevicular fluid MMP-8-concentrations in patients after acute myocardial
      infarction.
PG  - 1
LID - 10.1186/1746-160X-7-1 [doi]
AB  - BACKGROUND: The aim of this study was to determine the presence of matrix
      metalloproteinase-8 in the gingival crevicular fluid (GCF) of patients after
      acute myocardial infarction (AMI). METHODS: A total of 48 GCF samples from 20 AMI
      patients, hospitalized at the Department of Cardiology and Angiology of the
      Johannes Gutenberg University Mainz, were investigated. Besides the myocardial
      infarction all patients suffered from chronic periodontal disease. Fifty-one GCF 
      samples from 20 healthy age matched individuals with similar periodontal
      conditions served as controls. The dental examination included the assessment of 
      oral hygiene, gingival inflammation, probing pocket depth, clinical attachment
      level and X-ray examination. The study was only carried out after the positive
      consent of the regional ethic commission. A quantitative assessment of aMMP-8
      levels in the gingival crevicular fluid was performed with the help of the
      DentoAnalyzer (Dentognostics GmbH, Jena, Germany), utilising an immunological
      procedure. RESULTS: The aMMP-8 concentrations found in the gingival crevicular
      fluid of the AMI patients significantly differed (p = 0.001; mean value 30.33 +/-
      41.99 ng/ml aMMP-8) from the control group (mean value 10.0 +/- 10.7 ng/ml
      aMMP-8). These findings suggest that periodontal inflammation in AMI patients
      might be associated with higher MMP-8-values compared to the healthy controls.
      CONCLUSIONS: The acute myocardial infarction seems to influence the degree of
      periodontal inflammation, thus the measurement of the gingival crevicular fluid
      MMP8 levels seems to be a helpful biochemical test to obtain information about
      the severity of the periodontal disease.
FAU - Ehlers, Vicky
AU  - Ehlers V
AD  - Department of Operative Dentistry, University Medical Centre of the Johannes
      Gutenberg University Mainz, Germany. vicky.ehlers@unimedizin-mainz.de
FAU - Willershausen, Ines
AU  - Willershausen I
FAU - Kraft, Joachim
AU  - Kraft J
FAU - Munzel, Thomas
AU  - Munzel T
FAU - Willershausen, Brita
AU  - Willershausen B
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110110
PL  - England
TA  - Head Face Med
JT  - Head & face medicine
JID - 101245792
RN  - 0 (Biomarkers)
RN  - EC 3.4.24.34 (Matrix Metalloproteinase 8)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/metabolism
MH  - Female
MH  - Gingival Crevicular Fluid/*enzymology
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 8/*metabolism
MH  - Middle Aged
MH  - Myocardial Infarction/complications/*enzymology
MH  - Periodontal Diseases/enzymology/etiology
MH  - Prognosis
PMC - PMC3022744
EDAT- 2011/01/12 06:00
MHDA- 2011/05/25 06:00
CRDT- 2011/01/12 06:00
PHST- 2010/04/12 00:00 [received]
PHST- 2011/01/10 00:00 [accepted]
PHST- 2011/01/12 06:00 [entrez]
PHST- 2011/01/12 06:00 [pubmed]
PHST- 2011/05/25 06:00 [medline]
AID - 1746-160X-7-1 [pii]
AID - 10.1186/1746-160X-7-1 [doi]
PST - epublish
SO  - Head Face Med. 2011 Jan 10;7:1. doi: 10.1186/1746-160X-7-1.


PMID- 21219433
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20131121
IS  - 1464-5491 (Electronic)
IS  - 0742-3071 (Linking)
VI  - 28
IP  - 2
DP  - 2011 Feb
TI  - Impact of pre-exercise rapid-acting insulin reductions on ketogenesis following
      running in Type 1 diabetes.
PG  - 218-22
LID - 10.1111/j.1464-5491.2010.03162.x [doi]
AB  - AIM: This study examined the effects of reductions to pre-exercise rapid-acting
      insulin dose on changes in blood beta-hydroxybutyrate, glucose, acid-base balance
      and counter-regulatory hormone responses to prolonged running in individuals with
      Type 1 diabetes. METHODS: Following ethical approval, seven participants with
      Type 1 diabetes (34+/-2 years, BMI 27+/-1 kg/m(2) ) completed this study. After
      preliminary testing, participants attended the laboratory four times, each time
      consuming a 1.12 MJ meal (60 g carbohydrate, 2 g fat, 2 g protein), with
      randomized amounts of their rapid-acting insulin: Full dose (mean 7.3+/-0.2
      units), 75% dose (mean 5.4+/-0.1 units), 50% dose (mean 3.7+/-0.1 units) or 25%
      dose (mean 1.8+/-0.1 units). After 2-h rest, participants completed 45 min
      running at 70+/-1% peak rate of oxygen consumption (VO(2peak) ). Blood
      metabolites and hormones were recorded over the 2-h rest and 3-h recovery. Data
      were analysed using repeated-measures ANOVA. RESULTS: Serum insulin peaked at 60 
      min in all conditions and was lowest after 25% insulin dose compared with full
      dose (P=0.03). After the 25% insulin dose immediately pre-exercise glucose
      concentration was higher than after the full or 50% dose (P<0.05). Resting
      beta-hydroxybutyrate gradually decreased during 2-h rest (P<0.05) with a similar 
      post-exercise peak of beta-hydroxybutyrate at 3 h (P>0.05). Post-exercise blood
      pH increased for 5 min to a similar extent with all insulin doses , but the rise 
      with the 25% dose was less compared with the full dose (P=0.01). Blood lactate
      and plasma catecholamines increased after running similarly with all insulin
      reduction conditions (P<0.05). Blood glucose area under the curve (BG(auc) )
      after the 25% insulin dose was greater than after the 75% dose (P=0.02).
      CONCLUSION: Ketogenesis following running was not influenced by reductions in
      pre-exercise rapid-acting insulin dose. This important preparatory strategy aids 
      preservation of blood glucose but poses no greater risk to exercise-induced
      ketone body formation.
CI  - (c) 2011 The Authors. Diabetic Medicine (c) 2011 Diabetes UK.
FAU - Bracken, R M
AU  - Bracken RM
AD  - Sports and Exercise Science Research Centre, School of Engineering, Swansea
      University, Singleton Park, Swansea, UK. r.m.bracken@swansea.ac.uk
FAU - West, D J
AU  - West DJ
FAU - Stephens, J W
AU  - Stephens JW
FAU - Kilduff, L P
AU  - Kilduff LP
FAU - Luzio, S
AU  - Luzio S
FAU - Bain, S C
AU  - Bain SC
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Diabet Med
JT  - Diabetic medicine : a journal of the British Diabetic Association
JID - 8500858
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (Ketone Bodies)
RN  - TZP1275679 (3-Hydroxybutyric Acid)
SB  - IM
MH  - 3-Hydroxybutyric Acid/blood
MH  - Adult
MH  - Blood Glucose/*drug effects/physiology
MH  - Body Mass Index
MH  - Diabetes Mellitus, Type 1/*drug therapy/metabolism/physiopathology
MH  - Energy Metabolism/*drug effects/physiology
MH  - Female
MH  - Humans
MH  - Insulin/administration & dosage/*pharmacokinetics
MH  - Ketone Bodies/*biosynthesis
MH  - Oxygen Consumption/*drug effects/physiology
MH  - Running/*physiology
MH  - Treatment Outcome
EDAT- 2011/01/12 06:00
MHDA- 2011/06/03 06:00
CRDT- 2011/01/12 06:00
PHST- 2011/01/12 06:00 [entrez]
PHST- 2011/01/12 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
AID - 10.1111/j.1464-5491.2010.03162.x [doi]
PST - ppublish
SO  - Diabet Med. 2011 Feb;28(2):218-22. doi: 10.1111/j.1464-5491.2010.03162.x.


PMID- 21219312
OWN - NLM
STAT- MEDLINE
DCOM- 20110509
LR  - 20110314
IS  - 1528-1167 (Electronic)
IS  - 0013-9580 (Linking)
VI  - 52
IP  - 3
DP  - 2011 Mar
TI  - Chronic high-frequency deep-brain stimulation in progressive myoclonic epilepsy
      in adulthood--report of five cases.
PG  - 489-96
LID - 10.1111/j.1528-1167.2010.02884.x [doi]
AB  - PURPOSE: To assess the efficacy and tolerability of chronic high-frequency deep
      brain stimulation (DBS) in adult patients with progressive myoclonic epilepsy
      (PME) syndromes. METHODS: Five adult patients (four male, 28-39 years) with PME
      underwent chronic high-frequency DBS according to a study protocol that had been 
      approved by the local ethics committee. Electrodes were implanted in the
      substantia nigra pars reticulata (SNr)/subthalamic nucleus (STN) region in the
      first patient and additionally in the ventral intermediate nucleus (VIM)
      bilaterally in the following four cases. Follow-up took place in intervals of 3
      months and DBS effects were compared with baseline frequency of passive and
      activation-induced myoclonic jerks and daily life performance 8 weeks prior to
      implantation. KEY FINDINGS: Follow-up periods ranged from 12-42 months (median 24
      months). The best clinical effects were seen with SNr/STN DBS in all patients.
      VIM stimulation failed to achieve acute therapeutic effects and revealed low
      side-effect thresholds and even triggering of myoclonia. In all patients the
      reduction of myoclonic seizures was observed and ranged between 30% and 100% as
      quantified by a standardized video protocol. All patients reported clinically
      relevant improvements of various capabilities such as free standing and walking
      or improved fine motor skills. In one patient with an excellent initial response 
      generalized tonic-clonic seizures increased after 3 months of stimulation
      following extensive trauma-related surgery. The best effect was seen in the least
      impaired patient. SIGNIFICANCE: DBS of the SNr/STN may be an effective treatment 
      option for patients with PME. Less impaired patients may benefit more markedly.
CI  - Wiley Periodicals, Inc. (c) 2011 International League Against Epilepsy.
FAU - Wille, Christian
AU  - Wille C
AD  - Division of Functional Neurosurgery, Neurosurgical Clinic,
      Heinrich-Heine-University, Duesseldorf, Germany.
FAU - Steinhoff, Bernhard J
AU  - Steinhoff BJ
FAU - Altenmuller, Dirk-Matthias
AU  - Altenmuller DM
FAU - Staack, Anke Maren
AU  - Staack AM
FAU - Bilic, Sofia
AU  - Bilic S
FAU - Nikkhah, Guido
AU  - Nikkhah G
FAU - Vesper, Jan
AU  - Vesper J
LA  - eng
PT  - Journal Article
DEP - 20110110
PL  - United States
TA  - Epilepsia
JT  - Epilepsia
JID - 2983306R
RN  - 0 (Anticonvulsants)
SB  - IM
MH  - Adult
MH  - Anticonvulsants/administration & dosage
MH  - Combined Modality Therapy
MH  - Deep Brain Stimulation/*methods
MH  - Dominance, Cerebral/physiology
MH  - Electroencephalography/*methods
MH  - Epilepsies, Myoclonic/physiopathology/*therapy
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Long-Term Care
MH  - Male
MH  - *Signal Processing, Computer-Assisted
MH  - Stereotaxic Techniques
MH  - Substantia Nigra/physiopathology
MH  - Subthalamic Nucleus/physiopathology
MH  - Treatment Outcome
MH  - Ventral Thalamic Nuclei/physiopathology
EDAT- 2011/01/12 06:00
MHDA- 2011/05/10 06:00
CRDT- 2011/01/12 06:00
PHST- 2011/01/12 06:00 [entrez]
PHST- 2011/01/12 06:00 [pubmed]
PHST- 2011/05/10 06:00 [medline]
AID - 10.1111/j.1528-1167.2010.02884.x [doi]
PST - ppublish
SO  - Epilepsia. 2011 Mar;52(3):489-96. doi: 10.1111/j.1528-1167.2010.02884.x. Epub
      2011 Jan 10.


PMID- 21219228
OWN - NLM
STAT- MEDLINE
DCOM- 20140923
LR  - 20220321
IS  - 1545-1569 (Electronic)
IS  - 1055-6656 (Linking)
VI  - 48
IP  - 3
DP  - 2011 May
TI  - The Americleft study: an inter-center study of treatment outcomes for patients
      with unilateral cleft lip and palate part 2. Dental arch relationships.
PG  - 244-51
LID - 10.1597/09-181.1 [doi]
AB  - OBJECTIVE: To compare maxillomandibular relationships for individuals with
      nonsyndromic complete unilateral cleft lip and palate using the Goslon Yardstick 
      for dental models. DESIGN: Retrospective cohort study. SETTING: Five cleft palate
      centers in North America. SUBJECTS: A total of 169 subjects with repaired
      complete unilateral cleft lip and palate who were consecutively treated at the
      five centers. METHODS: Ethics approval was obtained. A total of 169 dental models
      of patients between 6 and 12 years old with complete unilateral cleft lip and
      palate were assessed using the Goslon Yardstick. Weighted kappa statistics were
      used to assess intrarater and interrater reliabilities; whereas, analysis of
      variance and Tukey-Kramer analysis was used to compare the Goslon scores.
      Significance levels were set at p < .05. RESULTS: Intrarater and interrater
      reliabilities were very good for model ratings. One center that incorporated
      primary alveolar bone grafting showed especially poor Goslon scores that were
      significantly poorer than the remaining centers. The surgery protocols used by
      the other four centers did not include primary alveolar bone grafting but
      involved a number of different lip and palate closure techniques. Using the
      Goslon Yardstick assumptions, the center with the best scores would be expected
      to require end-stage maxillary advancement orthognathic surgery in 20% of its
      patients; whereas, the center with the worst scores would be likely to require
      this surgery in 66% of its patients. CONCLUSIONS: The Goslon Yardstick proved
      capable of discriminating among the centers' dental arch relationships. Possible 
      explanations for the differences are discussed.
FAU - Hathaway, Ronald
AU  - Hathaway R
AD  - Craniofacial Center, Peyton Manning Children's Hospital at St. Vincent,
      Indianapolis, Indiana, USA.
FAU - Daskalogiannakis, John
AU  - Daskalogiannakis J
FAU - Mercado, Ana
AU  - Mercado A
FAU - Russell, Kathleen
AU  - Russell K
FAU - Long, Ross E Jr
AU  - Long RE Jr
FAU - Cohen, Marilyn
AU  - Cohen M
FAU - Semb, Gunvor
AU  - Semb G
FAU - Shaw, William
AU  - Shaw W
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20110110
PL  - United States
TA  - Cleft Palate Craniofac J
JT  - The Cleft palate-craniofacial journal : official publication of the American
      Cleft Palate-Craniofacial Association
JID - 9102566
SB  - IM
MH  - Alveolar Ridge Augmentation
MH  - Child
MH  - Cleft Lip/epidemiology/*surgery
MH  - Cleft Palate/epidemiology/*surgery
MH  - Dental Arch/*anatomy & histology
MH  - Female
MH  - Humans
MH  - Male
MH  - *Models, Dental
MH  - North America/epidemiology
MH  - *Outcome Assessment, Health Care
MH  - Reproducibility of Results
MH  - Research Design
MH  - Retrospective Studies
EDAT- 2011/01/12 06:00
MHDA- 2014/09/24 06:00
CRDT- 2011/01/12 06:00
PHST- 2011/01/12 06:00 [entrez]
PHST- 2011/01/12 06:00 [pubmed]
PHST- 2014/09/24 06:00 [medline]
AID - 10.1597/09-181.1 [doi]
PST - ppublish
SO  - Cleft Palate Craniofac J. 2011 May;48(3):244-51. doi: 10.1597/09-181.1. Epub 2011
      Jan 10.


PMID- 21219227
OWN - NLM
STAT- MEDLINE
DCOM- 20140923
LR  - 20220321
IS  - 1545-1569 (Electronic)
IS  - 1055-6656 (Linking)
VI  - 48
IP  - 3
DP  - 2011 May
TI  - The Americleft study: an inter-center study of treatment outcomes for patients
      with unilateral cleft lip and palate part 4. Nasolabial aesthetics.
PG  - 259-64
LID - 10.1597/09-186.1 [doi]
AB  - OBJECTIVE: To compare the nasolabial aesthetics for individuals with nonsyndromic
      complete unilateral cleft lip and palate between the ages of 5 and 12 years.
      DESIGN: Retrospective cross-sectional study. SETTING: Four cleft centers in North
      America. SUBJECTS: A total of 124 subjects with repaired complete unilateral
      cleft lip and palate who were treated at the four centers. METHODS: After ethics 
      approval was obtained, 124 preorthodontic frontal and profile patient images were
      scanned, cropped to show the nose and upper lip, and coded. Using the coded
      images, four nasolabial features that reflect aesthetics (i.e., nasal symmetry,
      nasal form, vermilion border, and nasolabial profile) were rated by five
      examiners using the rating system reported by Asher-McDade et al. (1991) .
      Intrarater and interrater reliabilities were determined using weighted kappa
      statistics. Mean ratings, by center, were compared using analysis of variance.
      RESULTS: Intrarater reliability scores were good to very good and interrater
      reliability scores were moderate to good. Total nasolabial scores were Center B =
      2.98, Center C = 3.02, Center D = 2.80, and Center E = 2.87. No statistically
      significant differences among centers were detected for both total aesthetic
      scores and for any of the individual aesthetic components. CONCLUSION: There were
      no significant differences in nasolabial aesthetics among the centers evaluated. 
      Overall good to fair nasolabial aesthetic results were achieved using the
      different treatment protocols in the four North American centers.
FAU - Mercado, Ana
AU  - Mercado A
AD  - Division of Orthodontics, College of Dentistry, The Ohio State University,
      Columbus, USA.
FAU - Russell, Kathleen
AU  - Russell K
FAU - Hathaway, Ronald
AU  - Hathaway R
FAU - Daskalogiannakis, John
AU  - Daskalogiannakis J
FAU - Sadek, Hani
AU  - Sadek H
FAU - Long, Ross E Jr
AU  - Long RE Jr
FAU - Cohen, Marilyn
AU  - Cohen M
FAU - Semb, Gunvor
AU  - Semb G
FAU - Shaw, William
AU  - Shaw W
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20110110
PL  - United States
TA  - Cleft Palate Craniofac J
JT  - The Cleft palate-craniofacial journal : official publication of the American
      Cleft Palate-Craniofacial Association
JID - 9102566
SB  - IM
MH  - Child
MH  - Cleft Lip/epidemiology/*surgery
MH  - Cleft Palate/epidemiology/*surgery
MH  - Cross-Sectional Studies
MH  - *Esthetics
MH  - Facial Asymmetry/*congenital
MH  - Female
MH  - Humans
MH  - *Lip
MH  - Male
MH  - North America/epidemiology
MH  - *Nose
MH  - *Outcome Assessment, Health Care
MH  - Research Design
MH  - Retrospective Studies
EDAT- 2011/01/12 06:00
MHDA- 2014/09/24 06:00
CRDT- 2011/01/12 06:00
PHST- 2011/01/12 06:00 [entrez]
PHST- 2011/01/12 06:00 [pubmed]
PHST- 2014/09/24 06:00 [medline]
AID - 10.1597/09-186.1 [doi]
PST - ppublish
SO  - Cleft Palate Craniofac J. 2011 May;48(3):259-64. doi: 10.1597/09-186.1. Epub 2011
      Jan 10.


PMID- 21219192
OWN - NLM
STAT- MEDLINE
DCOM- 20110729
LR  - 20120507
IS  - 1548-5951 (Electronic)
IS  - 1548-5943 (Linking)
VI  - 7
DP  - 2011
TI  - Psychologists and detainee interrogations: key decisions, opportunities lost, and
      lessons learned.
PG  - 459-81
LID - 10.1146/annurev-clinpsy-032210-104612 [doi]
AB  - After the 9-11 terrorist attacks, U.S. psychologists faced hard choices about
      what roles, if any, were appropriate for psychologists in the detainee
      interrogations conducted in settings such as the Bagram Airbase, the Abu Ghraib
      Prison, and the Guantanamo Bay Detention Camps. The American Psychological
      Association (APA) sparked intense controversy with its policies and public
      statements. This article reviews APA decisions, documents, and public statements 
      in this area, in the context of major criticisms and responses to those
      criticisms. The review focuses on key issues: how the APA created and reported
      policies in the areas of ethics and national security; transparency;
      psychologists' professional identities; psychologists' qualifications;
      ethical-legal conflicts; policies opposing torture; interpretations of avoiding
      harm; and effective interrogations. It suggests lessons learned, missed
      opportunities, and questions in need of a fresh approach.
CI  - (c) 2011 by Annual Reviews. All rights reserved
FAU - Pope, Kenneth S
AU  - Pope KS
AD  - kspope@mac.com
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Annu Rev Clin Psychol
JT  - Annual review of clinical psychology
JID - 101235325
SB  - IM
MH  - Humans
MH  - Policy
MH  - Prisoners/legislation & jurisprudence/*psychology
MH  - Psychology/*ethics/legislation & jurisprudence
MH  - Societies, Scientific/ethics
MH  - Terrorism/ethics
MH  - Torture/ethics
MH  - United States
EDAT- 2011/01/12 06:00
MHDA- 2011/07/30 06:00
CRDT- 2011/01/12 06:00
PHST- 2011/01/12 06:00 [entrez]
PHST- 2011/01/12 06:00 [pubmed]
PHST- 2011/07/30 06:00 [medline]
AID - 10.1146/annurev-clinpsy-032210-104612 [doi]
PST - ppublish
SO  - Annu Rev Clin Psychol. 2011;7:459-81. doi: 10.1146/annurev-clinpsy-032210-104612.


PMID- 21218354
OWN - NLM
STAT- MEDLINE
DCOM- 20110406
LR  - 20110110
IS  - 1545-5882 (Electronic)
IS  - 0145-9740 (Linking)
VI  - 30
IP  - 1
DP  - 2011 Jan
TI  - Communicating biosecurity.
PG  - 6-29
LID - 10.1080/01459740.2010.531066 [doi]
AB  - Shifting from risk-calculation orientations focusing on populations to
      preparedness perspectives that model uncertainty through scenario-based
      projections, biosecurity debates redefined notions of "health" and "security."
      Nevertheless, a key focus of biosecurity discussions--the domain labeled
      "communication"--has not been fundamentally rethought, even as it has expanded
      and professionalized. Bracketing preconceived ideas about the term's content, the
      article traces debates about biosecurity "communication" from the 1990s to the
      present, drawing on ethnography and textual analysis. Using a notion of
      biocommunicability, the cultural modeling of how discourse is produced,
      circulates, and is received, the article analyzes assumptions regarding subjects,
      subject-positions, objects, spatializing and temporalizing practices, scales,
      economies of affect, and regimes of ethics that are built into discourse about
      "communication." Ironically, the conviction that "communication" is of marginal
      importance as a focus of critical inquiry, seemingly shared by most medical
      anthropologists, enables these assumptions to fundamentally shape discussions of 
      biosecurity and emergency management.
FAU - Briggs, Charles L
AU  - Briggs CL
AD  - Department of Anthropology, University of California, Berkeley, CA 94720, USA.
      clbriggs@berkeley.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Anthropol
JT  - Medical anthropology
JID - 7707343
SB  - IM
MH  - Bioterrorism/*prevention & control
MH  - Civil Defense/*methods
MH  - *Communication
MH  - Disaster Planning
MH  - Models, Theoretical
MH  - Risk Assessment/methods
EDAT- 2011/01/11 06:00
MHDA- 2011/04/07 06:00
CRDT- 2011/01/11 06:00
PHST- 2011/01/11 06:00 [entrez]
PHST- 2011/01/11 06:00 [pubmed]
PHST- 2011/04/07 06:00 [medline]
AID - 931969965 [pii]
AID - 10.1080/01459740.2010.531066 [doi]
PST - ppublish
SO  - Med Anthropol. 2011 Jan;30(1):6-29. doi: 10.1080/01459740.2010.531066.


PMID- 21218302
OWN - NLM
STAT- MEDLINE
DCOM- 20110629
LR  - 20191210
IS  - 1532-7027 (Electronic)
IS  - 1041-0236 (Linking)
VI  - 26
IP  - 1
DP  - 2011 Jan
TI  - Measuring cancer clinical trial understanding.
PG  - 82-93
LID - 10.1080/10410236.2011.527624 [doi]
AB  - Researchers, practitioners, and participants in cancer clinical trials must have 
      a clear understanding of clinical trials if participation in them is to be
      solicited ethically and effectively. A valid and reliable measure of cancer
      clinical trial understanding did not exist prior to a 2005 study conducted for
      the Coalition of Cooperative Cancer Groups. This report outlines a measure
      derived from that study, discusses the rationale for its component items,
      examines its psychometric properties, and demonstrates the relationship of this
      measure to the enrollment decision. Data from national samples of cancer
      survivors and the general public demonstrate the measure's validity and
      reliability. Results are discussed as they relate to patient understanding of
      clinical trials, informed decision making, and health communication processes.
FAU - Miller, Jon D
AU  - Miller JD
AD  - Institute for Social Research, University of Michigan, Ann Arbor, MI 48823, USA. 
      jondmiller@umich.edu
FAU - Kotowski, Michael R
AU  - Kotowski MR
FAU - Comis, Robert L
AU  - Comis RL
FAU - Smith, Sandi W
AU  - Smith SW
FAU - Silk, Kami J
AU  - Silk KJ
FAU - Colaizzi, Diane D
AU  - Colaizzi DD
FAU - Kimmel, Linda G
AU  - Kimmel LG
LA  - eng
PT  - Journal Article
PT  - Validation Study
PL  - England
TA  - Health Commun
JT  - Health communication
JID - 8908762
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Antineoplastic Agents/therapeutic use
MH  - Clinical Trials as Topic/*psychology
MH  - Decision Making
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/drug therapy/*psychology
MH  - Patient Participation/*psychology
MH  - Psychometrics
MH  - Research Subjects/*psychology
MH  - Surveys and Questionnaires/standards
MH  - Young Adult
EDAT- 2011/01/11 06:00
MHDA- 2011/06/30 06:00
CRDT- 2011/01/11 06:00
PHST- 2011/01/11 06:00 [entrez]
PHST- 2011/01/11 06:00 [pubmed]
PHST- 2011/06/30 06:00 [medline]
AID - 931965914 [pii]
AID - 10.1080/10410236.2011.527624 [doi]
PST - ppublish
SO  - Health Commun. 2011 Jan;26(1):82-93. doi: 10.1080/10410236.2011.527624.


PMID- 21216890
OWN - NLM
STAT- MEDLINE
DCOM- 20110523
LR  - 20211020
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 37
IP  - 4
DP  - 2011 Apr
TI  - Ethically complex decisions in the neonatal intensive care unit: impact of the
      new French legislation on attitudes and practices of physicians and nurses.
PG  - 240-3
LID - 10.1136/jme.2010.038356 [doi]
AB  - OBJECTIVES: A statute enacted in 2005 modified the legislative framework of the
      rights of terminally ill persons in France. Ten years after the EURONIC study,
      which described the self-reported practices of neonatal caregivers towards
      ethical decision-making, a new study was conducted to assess the impact of the
      new law in neonatal intensive care units (NICU) and compare the results reported 
      by EURONIC with current practices. SETTING AND DESIGN: The study was carried out 
      in the same two NICU as in the EURONIC qualitative study. A third centre was
      added to increase the sample size. From February to October 2007, 19 physicians
      and 17 nurses participated in semistructured interviews very similar to those for
      EURONIC. Content analysis identified the recurring themes emerging from the
      interviews. RESULTS: Compared with the EURONIC results, the caregivers reported
      that they pay greater attention to the views of parents and provided respectful
      support to the neonates when life-sustaining treatment is withdrawn. Active
      termination of life has become exceptional. The possibility of withdrawal of
      treatment, the administration of sedatives to control pain even at the risk of
      hastening death, the emphasis on sparing parents the burden of decision, and the 
      relative ignorance of the law were very similar to the EURONIC findings.
      CONCLUSION: Both the medical and the legal regulation of practices has allowed
      more dialogue with the parents and more humane care for dying newborns. A new
      European study is necessary to investigate the possible changes in practices and 
      attitudes also in other countries.
FAU - Garel, Micheline
AU  - Garel M
AD  - INSERM U 953, 16 avenue Paul Vaillant-Couturier, 94807 Villejuif Cedex, France.
      micheline.garel@inserm.fr
FAU - Caeymaex, Laurence
AU  - Caeymaex L
FAU - Goffinet, Francois
AU  - Goffinet F
FAU - Cuttini, Marina
AU  - Cuttini M
FAU - Kaminski, Monique
AU  - Kaminski M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110107
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Attitude of Health Personnel
MH  - Decision Making/*ethics
MH  - Euthanasia/ethics/*legislation & jurisprudence/psychology
MH  - Female
MH  - France
MH  - Humans
MH  - Infant, Newborn
MH  - Intensive Care Units, Neonatal/*ethics/legislation & jurisprudence
MH  - Male
MH  - Medical Staff, Hospital/*psychology
MH  - Middle Aged
MH  - Nursing Staff, Hospital/*psychology
MH  - Parents/psychology
MH  - Young Adult
PMC - PMC3320580
MID - HALMS578566
OID - NLM: HALMS578566
EDAT- 2011/01/11 06:00
MHDA- 2011/05/24 06:00
CRDT- 2011/01/11 06:00
PHST- 2011/01/11 06:00 [entrez]
PHST- 2011/01/11 06:00 [pubmed]
PHST- 2011/05/24 06:00 [medline]
AID - jme.2010.038356 [pii]
AID - 10.1136/jme.2010.038356 [doi]
PST - ppublish
SO  - J Med Ethics. 2011 Apr;37(4):240-3. doi: 10.1136/jme.2010.038356. Epub 2011 Jan
      7.


PMID- 21216318
OWN - NLM
STAT- MEDLINE
DCOM- 20110617
LR  - 20110207
IS  - 1873-2518 (Electronic)
IS  - 0264-410X (Linking)
VI  - 29
IP  - 9
DP  - 2011 Feb 17
TI  - Employee designation and health care worker support of an influenza vaccine
      mandate at a large pediatric tertiary care hospital.
PG  - 1762-9
LID - 10.1016/j.vaccine.2010.12.115 [doi]
AB  - AIM: Determine predictors of support of a mandatory seasonal influenza vaccine
      program among health care workers (HCWs). SCOPE: Cross-sectional anonymous survey
      of 2443 (out of 8093) randomly selected clinical and non-clinical HCWs at a large
      pediatric network after implementation of a mandatory vaccination program in
      2009-10. RESULTS: 1388 HCWs (58.2%) completed the survey and 75.2% of respondents
      reported agreeing with the new mandatory policy. Most respondents (72%) believed 
      that the policy was coercive but >90% agreed that the policy was important for
      protecting patients and staff and was part of professional ethical
      responsibility. When we adjusted for attitudes and beliefs regarding influenza
      and the mandate, there was no significant difference between clinical and
      nonclinical staff in their support of the mandate (OR 1.08, 95% C.I. 0.94, 1.26).
      CONCLUSIONS: Attitudes and beliefs regarding influenza and the mandate may
      transcend professional role. Targeted outreach activities can capitalize on
      beliefs regarding patient protection and ethical responsibility.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Feemster, Kristen A
AU  - Feemster KA
AD  - Division of Infectious Diseases, Department of Pediatrics, The Children's
      Hospital of Philadelphia, Philadelphia, PA 19104, USA. feemster@email.chop.edu
FAU - Prasad, Priya
AU  - Prasad P
FAU - Smith, Michael J
AU  - Smith MJ
FAU - Feudtner, Chris
AU  - Feudtner C
FAU - Caplan, Arthur
AU  - Caplan A
FAU - Offit, Paul
AU  - Offit P
FAU - Coffin, Susan E
AU  - Coffin SE
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20110107
PL  - Netherlands
TA  - Vaccine
JT  - Vaccine
JID - 8406899
RN  - 0 (Influenza Vaccines)
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Cross-Sectional Studies
MH  - Health Personnel/legislation & jurisprudence/*psychology
MH  - *Hospitals, Pediatric/legislation & jurisprudence/trends
MH  - Humans
MH  - Influenza Vaccines/*therapeutic use
MH  - *Mandatory Programs/legislation & jurisprudence/trends
MH  - Middle Aged
MH  - *Occupational Health/legislation & jurisprudence
EDAT- 2011/01/11 06:00
MHDA- 2011/06/18 06:00
CRDT- 2011/01/11 06:00
PHST- 2010/11/12 00:00 [received]
PHST- 2010/12/17 00:00 [revised]
PHST- 2010/12/22 00:00 [accepted]
PHST- 2011/01/11 06:00 [entrez]
PHST- 2011/01/11 06:00 [pubmed]
PHST- 2011/06/18 06:00 [medline]
AID - S0264-410X(10)01902-X [pii]
AID - 10.1016/j.vaccine.2010.12.115 [doi]
PST - ppublish
SO  - Vaccine. 2011 Feb 17;29(9):1762-9. doi: 10.1016/j.vaccine.2010.12.115. Epub 2011 
      Jan 7.


PMID- 21216212
OWN - NLM
STAT- MEDLINE
DCOM- 20110729
LR  - 20181201
IS  - 1872-9177 (Electronic)
IS  - 1769-7255 (Linking)
VI  - 7
IP  - 1
DP  - 2011 Feb
TI  - [Conceptions guiding the organization of organ procurement and transplantation in
      France, Canada and the United States].
PG  - 59-66
LID - 10.1016/j.nephro.2010.12.001 [doi]
AB  - The goal of the seminar which took place in Paris on April 15th and 16th, 2010,
      was to understand the reasons which lead, on both side of the Atlantic and from a
      common basis of values, to different choice about essential rules concerning:
      consent strategies for after death organ donation: non heart beating donation;
      anonymity; living donation; paired-exchange donation ("crossed donation");
      altruistic donation ("good Samaritan"); donation incentives; the place devoted to
      patient's representatives in health systems. The seminar also aimed at providing 
      the French legislator, while the law on bioethics was being discussed, with
      international perspective and useful information regarding ethical practices and 
      reflections on these issues.
CI  - Copyright (c) 2010 Association Societe de nephrologie. Published by Elsevier SAS.
      All rights reserved.
FAU - Caille, Yvanie
AU  - Caille Y
AD  - Groupe de reflexion Demain la Greffe, 48, rue Eugene-Oudine, 75013 Paris, France.
      mail@yvanie.fr
FAU - Doucin, Michel
AU  - Doucin M
LA  - fre
PT  - Congress
TT  - Les conceptions presidant a l'organisation du prelevement d'organes et de la
      greffe en France, au Canada et aux Etats-Unis.
DEP - 20110107
PL  - France
TA  - Nephrol Ther
JT  - Nephrologie & therapeutique
JID - 101248950
SB  - IM
MH  - Canada
MH  - France
MH  - Humans
MH  - *Kidney Transplantation
MH  - Tissue Donors
MH  - Tissue and Organ Procurement/*organization & administration
MH  - United States
EDAT- 2011/01/11 06:00
MHDA- 2011/07/30 06:00
CRDT- 2011/01/11 06:00
PHST- 2010/11/28 00:00 [received]
PHST- 2010/11/29 00:00 [revised]
PHST- 2010/11/30 00:00 [accepted]
PHST- 2011/01/11 06:00 [entrez]
PHST- 2011/01/11 06:00 [pubmed]
PHST- 2011/07/30 06:00 [medline]
AID - S1769-7255(10)00253-1 [pii]
AID - 10.1016/j.nephro.2010.12.001 [doi]
PST - ppublish
SO  - Nephrol Ther. 2011 Feb;7(1):59-66. doi: 10.1016/j.nephro.2010.12.001. Epub 2011
      Jan 7.


PMID- 21216029
OWN - NLM
STAT- MEDLINE
DCOM- 20110503
LR  - 20110128
IS  - 1532-2939 (Electronic)
IS  - 0195-6701 (Linking)
VI  - 77
IP  - 2
DP  - 2011 Feb
TI  - Meticillin-resistant Staphylococcus aureus infection--the infectious stigma of
      our time?
PG  - 148-52
LID - 10.1016/j.jhin.2010.09.029 [doi]
AB  - The article discusses ethical aspects related to isolation of patients with
      infectious diseases. The empirical basis is a textual analysis of two national
      guidelines on prevention of spreading of patients with meticillin-resistant
      Staphylococcus aureus. The analysis shows that even though both documents are
      founded upon updated scientific evidence on epidemiology and infectious diseases 
      they lack explicit ethical argumentation on several aspects relevant for
      treatment and care under isolation or other constraints. Presuming that written
      guidelines make important frames for reflection and learning among practitioners,
      the authors suggest that such guidelines not just in Scandinavia but
      internationally should show how ethical considerations can be included into the
      individual risk assessments concerning patients under isolation.
CI  - Copyright (c) 2010 The Hospital Infection Society. Published by Elsevier Ltd. All
      rights reserved.
FAU - Braut, G S
AU  - Braut GS
AD  - Norwegian Board of Health Supervision, Oslo, Norway. gsb@helsetilsynet.no
FAU - Holt, J
AU  - Holt J
LA  - eng
PT  - Journal Article
DEP - 20110107
PL  - England
TA  - J Hosp Infect
JT  - The Journal of hospital infection
JID - 8007166
SB  - IM
MH  - Denmark
MH  - Guidelines as Topic
MH  - Humans
MH  - *Methicillin-Resistant Staphylococcus aureus/isolation & purification
MH  - Norway
MH  - Patient Isolation/*ethics
MH  - Risk Assessment
MH  - Staphylococcal Infections/*prevention & control/transmission
EDAT- 2011/01/11 06:00
MHDA- 2011/05/04 06:00
CRDT- 2011/01/11 06:00
PHST- 2010/07/15 00:00 [received]
PHST- 2010/09/24 00:00 [accepted]
PHST- 2011/01/11 06:00 [entrez]
PHST- 2011/01/11 06:00 [pubmed]
PHST- 2011/05/04 06:00 [medline]
AID - S0195-6701(10)00444-5 [pii]
AID - 10.1016/j.jhin.2010.09.029 [doi]
PST - ppublish
SO  - J Hosp Infect. 2011 Feb;77(2):148-52. doi: 10.1016/j.jhin.2010.09.029. Epub 2011 
      Jan 7.


PMID- 21215821
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20161222
IS  - 1556-3871 (Electronic)
IS  - 1547-5271 (Linking)
VI  - 8
IP  - 6
DP  - 2011 Jun
TI  - Clinical considerations for allied professionals on research ethics--Vulnerable
      research participant populations: ensuring ethical recruitment and enrolment.
PG  - 947-50
LID - 10.1016/j.hrthm.2011.01.005 [doi]
FAU - Reel, Kevin
AU  - Reel K
AD  - Southlake Regional Health Centre, Newmarket, Ontario, Canada.
      kevin.reel@utoronto.ca
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20110106
PL  - United States
TA  - Heart Rhythm
JT  - Heart rhythm
JID - 101200317
RN  - 0 (Anti-Arrhythmia Agents)
SB  - IM
MH  - Aged
MH  - Anti-Arrhythmia Agents/*therapeutic use
MH  - Atrial Fibrillation/psychology/*therapy
MH  - Catheter Ablation/*ethics/methods
MH  - *Ethics, Research
MH  - Female
MH  - Humans
MH  - Patient Selection/*ethics
MH  - Physician-Patient Relations/*ethics
MH  - *Vulnerable Populations
EDAT- 2011/01/11 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/01/11 06:00
PHST- 2010/11/02 00:00 [received]
PHST- 2011/01/11 06:00 [entrez]
PHST- 2011/01/11 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S1547-5271(11)00007-5 [pii]
AID - 10.1016/j.hrthm.2011.01.005 [doi]
PST - ppublish
SO  - Heart Rhythm. 2011 Jun;8(6):947-50. doi: 10.1016/j.hrthm.2011.01.005. Epub 2011
      Jan 6.


PMID- 21215592
OWN - NLM
STAT- MEDLINE
DCOM- 20110527
LR  - 20131121
IS  - 1769-6623 (Electronic)
IS  - 0750-7658 (Linking)
VI  - 30
IP  - 1
DP  - 2011 Jan
TI  - [Tranexamic acid reduces haematomas but not pain after total knee arthroplasty].
PG  - 17-24
LID - 10.1016/j.annfar.2010.11.017 [doi]
AB  - AIM: Tranexamic acid (TxA) reduces total blood losses (TBL) and allogenic
      transfusion (TH) after total knee arthroplasty (TKA). TBL can be external
      (surgical field, drains), or hidden (haematomas). Haematomas induce pain and
      limit postoperative rehabilitation. The aim of the study was to evaluate if TxA
      reduces haematomas and pain after TKA. STUDY DESIGN: Prospective non-randomized
      study. METHOD: After ethical committee approvement and written informed consent, 
      the patients planned for a primary TKA were included (control group followed by a
      TxA group, 15 mg/kg before incision and at skin closure). General anaesthesia and
      analgesia were standardized (sciatic block, continuous femoral block, ketamine,
      ketoprofene, paracetamol, PCA with morphine). Volume of haematomas=TBL
      (calculated based on haemograms performed the day before surgery, and at
      postoperative day 5, and on transfusions)-measured external bleeding. Patients
      were followed up for 8 days, and at postoperative day 180 (by phone). Fifty
      patients per group allowed the detection of a 50% morphine sparing at day 8
      (alpha=0.05 and beta=0.2), and a 25% reduction of haematoma volumes at day 5.
      RESULTS: Perioperative data, pain scores and functional parameters (until day
      180) were not different between control group patients (n=52) and TxA group
      patients (n=55): morphine consumption at day 8 was respectively 35 +/- 32 and 42 
      +/- 38 mg (P=0.29). Yet, TxA reduced hematoma volumes (526 +/- 202 versus 337 +/-
      165 mL of red blood cells, P<0.0001) and clinically apparent hematomas. Morphine 
      consumptions at day 8 and haematoma volumes were not correlated. CONCLUSION:
      After TKA, TxA reduces the volume of hematomas, without any improvement in
      analgesia and rehabilitation until the sixth postoperative month.
CI  - Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
FAU - Chevet, I
AU  - Chevet I
AD  - Pole anesthesie-reanimation Samu, hopital Trousseau, CHRU de Tours, universite
      Francois-Rabelais, avenue de la republique a Chambray-les-Tours, 37044 Tours
      cedex 9, France.
FAU - Remerand, F
AU  - Remerand F
FAU - Couvret, C
AU  - Couvret C
FAU - Baud, A
AU  - Baud A
FAU - Pouplard, C
AU  - Pouplard C
FAU - Rosset, P
AU  - Rosset P
FAU - Laffon, M
AU  - Laffon M
FAU - Fusciardi, J
AU  - Fusciardi J
LA  - fre
PT  - Clinical Trial
PT  - English Abstract
PT  - Journal Article
TT  - L'acide tranexamique diminue les hematomes mais pas les douleurs apres prothese
      totale de genou.
DEP - 20110106
PL  - France
TA  - Ann Fr Anesth Reanim
JT  - Annales francaises d'anesthesie et de reanimation
JID - 8213275
RN  - 0 (Antifibrinolytic Agents)
RN  - 6T84R30KC1 (Tranexamic Acid)
SB  - IM
MH  - Aged
MH  - Anesthesia, General
MH  - Antifibrinolytic Agents/administration & dosage/*therapeutic use
MH  - *Arthroplasty, Replacement, Knee
MH  - Female
MH  - Hematoma/*prevention & control
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Block
MH  - Pain Measurement
MH  - Pain, Postoperative/*prevention & control
MH  - Postoperative Complications/*prevention & control
MH  - Postoperative Hemorrhage/prevention & control
MH  - Prospective Studies
MH  - Tranexamic Acid/administration & dosage/*therapeutic use
EDAT- 2011/01/11 06:00
MHDA- 2011/05/28 06:00
CRDT- 2011/01/11 06:00
PHST- 2010/08/02 00:00 [received]
PHST- 2010/11/23 00:00 [accepted]
PHST- 2011/01/11 06:00 [entrez]
PHST- 2011/01/11 06:00 [pubmed]
PHST- 2011/05/28 06:00 [medline]
AID - S0750-7658(10)00524-1 [pii]
AID - 10.1016/j.annfar.2010.11.017 [doi]
PST - ppublish
SO  - Ann Fr Anesth Reanim. 2011 Jan;30(1):17-24. doi: 10.1016/j.annfar.2010.11.017.
      Epub 2011 Jan 6.


PMID- 21213192
OWN - NLM
STAT- MEDLINE
DCOM- 20110421
LR  - 20191210
IS  - 1937-190X (Electronic)
IS  - 1937-190X (Linking)
VI  - 26
IP  - 1
DP  - 2011
TI  - Addressing health disparities: the role of an African American health ministry
      committee.
PG  - 123-35
LID - 10.1080/10911350902987078 [doi]
AB  - Healthy People 2010 identified the need to address health disparities among
      African Americans, Asians, American Indians, Hispanics, Alaskan American, and
      Pacific Islanders. These are groups disproportionately affected by cancer,
      cardiovascular disease, diabetes, HIV infection, and AIDSs. Despite the growing
      body of research on health disparities and effective interventions, there is a
      great need to learn more about culturally appropriate interventions. Social work 
      professional values and ethics require that service delivery be culturally
      competent and effective. Social workers can collaborate with community based
      health promotion services, exploring new ways to ensure that health disparities
      can be addressed in institutions to which African Americans belong. This article 
      presents findings of an African American health ministry committee's health
      promotion initiatives and probed the viability of a health ministry committee'
      role in addressing health disparities through education. The promising role of
      the Black church in addressing health disparities is explored.
FAU - Austin, Sandra
AU  - Austin S
AD  - School of Social Wellfare, University of Albany, State University of New York,
      Albany, New York, USA. saustin@albany.edu
FAU - Harris, Gertrude
AU  - Harris G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Soc Work Public Health
JT  - Social work in public health
JID - 101308228
MH  - Adolescent
MH  - Adult
MH  - Advisory Committees
MH  - African Americans/*statistics & numerical data
MH  - Chi-Square Distribution
MH  - Community Health Services
MH  - Community-Based Participatory Research
MH  - Female
MH  - *Health Promotion
MH  - Health Status
MH  - *Health Status Disparities
MH  - Humans
MH  - Interpersonal Relations
MH  - Male
MH  - Middle Aged
MH  - Power, Psychological
MH  - Religion
MH  - *Social Marketing
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2011/01/08 06:00
MHDA- 2011/04/22 06:00
CRDT- 2011/01/08 06:00
PHST- 2011/01/08 06:00 [entrez]
PHST- 2011/01/08 06:00 [pubmed]
PHST- 2011/04/22 06:00 [medline]
AID - 931820106 [pii]
AID - 10.1080/10911350902987078 [doi]
PST - ppublish
SO  - Soc Work Public Health. 2011;26(1):123-35. doi: 10.1080/10911350902987078.


PMID- 21212915
OWN - NLM
STAT- MEDLINE
DCOM- 20110428
LR  - 20110107
IS  - 0379-5284 (Print)
IS  - 0379-5284 (Linking)
VI  - 32
IP  - 1
DP  - 2011 Jan
TI  - Trend in cesarean section rate.
PG  - 41-5
AB  - OBJECTIVE: To investigate factors influencing the increase in cesarean section CS
      rates, and to implement control measures. METHODS: This retrospective analysis
      reviewed the birth registry of the Department of Obstetrics and Gynecology, King 
      Fahd Armed Forces Hospital, Jeddah, Saudi Arabia. We compared the frequency of
      different indications for CS between January 2007 and December 2008. The numbers 
      of CS studied were 1105 in 2007, while they were 1226 in the year 2008. Thus, the
      sample size studied was 2331 cesarean deliveries. Approval of the ethical
      committee for publication was obtained. RESULTS: The CS rate exceeded the
      acceptable 15% rate suggested by the World Health Organization (WHO) at our
      institution, and probably in many other hospitals in Saudi Arabia. Fetal
      distress, previous single CS, previous multiple CS, and breech presentation were 
      the most common indications for CS. CONCLUSION: This high rate of CS will
      continue to increase due to the tendency to have large families, and the
      self-perpetuating character of each CS. Efforts should be made at each hospital
      level, and nationwide, to control this tendency.
FAU - Bondok, Walaa M
AU  - Bondok WM
AD  - Department of Obstetrics and Gynecology, King Fahd Armed Forces Hospital, Jeddah,
      Kingdom of Saudi Arabia.
FAU - El-Shehry, Saleh H
AU  - El-Shehry SH
FAU - Fadllallah, Samira M
AU  - Fadllallah SM
LA  - eng
PT  - Journal Article
PL  - Saudi Arabia
TA  - Saudi Med J
JT  - Saudi medical journal
JID - 7909441
SB  - IM
MH  - Adult
MH  - Breech Presentation
MH  - Cesarean Section/*trends
MH  - Cesarean Section, Repeat/statistics & numerical data
MH  - Female
MH  - Fetal Distress/surgery
MH  - Humans
MH  - Pregnancy
MH  - Retrospective Studies
MH  - Saudi Arabia
EDAT- 2011/01/08 06:00
MHDA- 2011/04/29 06:00
CRDT- 2011/01/08 06:00
PHST- 2011/01/08 06:00 [entrez]
PHST- 2011/01/08 06:00 [pubmed]
PHST- 2011/04/29 06:00 [medline]
AID - 0' [pii]
PST - ppublish
SO  - Saudi Med J. 2011 Jan;32(1):41-5.


PMID- 21212341
OWN - NLM
STAT- MEDLINE
DCOM- 20110124
LR  - 20110107
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Linking)
VI  - 331
IP  - 6013
DP  - 2011 Jan 7
TI  - Ethics. Bad science used to support torture and human experimentation.
PG  - 34-5
LID - 10.1126/science.1194437 [doi]
FAU - Iacopino, Vincent
AU  - Iacopino V
AD  - Physicians for Human Rights, Cambridge, MA 02138, USA.
FAU - Allen, Scott A
AU  - Allen SA
FAU - Keller, Allen S
AU  - Keller AS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
SB  - IM
MH  - Ethics, Medical
MH  - *Ethics, Professional
MH  - Ethics, Research
MH  - Federal Government
MH  - *Human Experimentation/ethics/legislation & jurisprudence
MH  - Humans
MH  - *Prisoners
MH  - *Torture/ethics/legislation & jurisprudence/psychology
MH  - United States
MH  - United States Department of Defense
EDAT- 2011/01/08 06:00
MHDA- 2011/01/25 06:00
CRDT- 2011/01/08 06:00
PHST- 2011/01/08 06:00 [entrez]
PHST- 2011/01/08 06:00 [pubmed]
PHST- 2011/01/25 06:00 [medline]
AID - 331/6013/34 [pii]
AID - 10.1126/science.1194437 [doi]
PST - ppublish
SO  - Science. 2011 Jan 7;331(6013):34-5. doi: 10.1126/science.1194437.


PMID- 21211915
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20211020
IS  - 1873-4111 (Electronic)
IS  - 0378-5122 (Linking)
VI  - 68
IP  - 4
DP  - 2011 Apr
TI  - Ethical challenges in human nutrigenomics research.
PG  - 297-8
LID - 10.1016/j.maturitas.2010.12.003 [doi]
FAU - Bergmann, Manuela M
AU  - Bergmann MM
FAU - Mathers, John C
AU  - Mathers JC
LA  - eng
GR  - G0900686/MRC_/Medical Research Council/United Kingdom
PT  - Editorial
DEP - 20110105
PL  - Ireland
TA  - Maturitas
JT  - Maturitas
JID - 7807333
SB  - IM
MH  - *Ethics, Research
MH  - Humans
MH  - Nutrigenomics/*ethics
EDAT- 2011/01/08 06:00
MHDA- 2011/11/09 06:00
CRDT- 2011/01/08 06:00
PHST- 2010/12/06 00:00 [received]
PHST- 2010/12/07 00:00 [accepted]
PHST- 2011/01/08 06:00 [entrez]
PHST- 2011/01/08 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - S0378-5122(10)00451-2 [pii]
AID - 10.1016/j.maturitas.2010.12.003 [doi]
PST - ppublish
SO  - Maturitas. 2011 Apr;68(4):297-8. doi: 10.1016/j.maturitas.2010.12.003. Epub 2011 
      Jan 5.


PMID- 21211560
OWN - NLM
STAT- MEDLINE
DCOM- 20111107
LR  - 20171116
IS  - 1872-7573 (Electronic)
IS  - 0378-8741 (Linking)
VI  - 134
IP  - 2
DP  - 2011 Mar 24
TI  - A double-blind randomized placebo-controlled clinical study to evaluate the
      efficacy and safety of a polyherbal formulation in geriatric age group: a phase
      IV clinical report.
PG  - 429-33
LID - 10.1016/j.jep.2010.12.044 [doi]
AB  - AIM OF THE STUDY: We sought to determine the efficacy as antioxidant and safety
      profile of the polyherbal formulation in geriatric patients of eastern India.
      MATERIALS AND METHODS: The study was double-blind, randomized including placebo
      controlled and was approved by the ethical committee of SSKM hospital. Geriatric 
      patients attending the OPD (outpatient department) of SSKM hospital formed the
      study group. The patients were randomized to receive either the polyherbal
      formulation or the identical-looking placebo at a dose of 2 tablets twice daily
      for a period of 6 months. Follow-up of patient status was done monthly. The
      clinical parameters were assessed before and after 6 months of medication or
      placebo intake. RESULTS: The results showed that significant rejuvenation of the 
      anti-oxidant property which is determined by the enzymatic and non enzymatic anti
      oxidants, superoxide dismutase, catalase, glutathione peroxidase, glutathione
      reductase, reduced glutathione and malondialdehyde in the geriatric patients were
      seen in patients treated with Geriforte tablets as compared to patients treated
      with placebo and control group. There were no significant adverse effects
      experienced by cases in any group. CONCLUSION: Polyherbal formulation is
      effective in rejuvenating geriatric age group compared to the placebo. This
      formulation is safe and compliance to the treatment was good. In ancient Ayurveda
      the constituents of polyherbal formulation were prescribed for different diseases
      including cardiological, neurological, sepsis, etc.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Banerjee, Payel
AU  - Banerjee P
AD  - Department of Biochemistry, University of Calcutta, 35 Ballygunge Circular Road, 
      Kolkata 700019, India.
FAU - Maity, Soumya
AU  - Maity S
FAU - Das, Tapas
AU  - Das T
FAU - Mazumder, Santasree
AU  - Mazumder S
LA  - eng
PT  - Clinical Trial, Phase IV
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110104
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Antioxidants)
RN  - 0 (Drug Combinations)
RN  - 0 (Plant Extracts)
RN  - 4Y8F71G49Q (Malondialdehyde)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antioxidants/administration & dosage/metabolism/*pharmacology
MH  - Double-Blind Method
MH  - Drug Combinations
MH  - Female
MH  - Humans
MH  - Magnoliopsida
MH  - Male
MH  - Malondialdehyde/blood
MH  - Middle Aged
MH  - *Phytotherapy
MH  - Plant Extracts/administration & dosage/*pharmacology
MH  - Stress, Physiological/*drug effects
MH  - Young Adult
EDAT- 2011/01/08 06:00
MHDA- 2011/11/08 06:00
CRDT- 2011/01/08 06:00
PHST- 2010/08/14 00:00 [received]
PHST- 2010/11/30 00:00 [revised]
PHST- 2010/12/29 00:00 [accepted]
PHST- 2011/01/08 06:00 [entrez]
PHST- 2011/01/08 06:00 [pubmed]
PHST- 2011/11/08 06:00 [medline]
AID - S0378-8741(10)00920-7 [pii]
AID - 10.1016/j.jep.2010.12.044 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2011 Mar 24;134(2):429-33. doi: 10.1016/j.jep.2010.12.044. Epub
      2011 Jan 4.


PMID- 21210882
OWN - NLM
STAT- MEDLINE
DCOM- 20110504
LR  - 20110107
IS  - 1460-9592 (Electronic)
IS  - 1155-5645 (Linking)
VI  - 21
IP  - 2
DP  - 2011 Feb
TI  - Emergency cricothyrotomy in infants--evaluation of a novel device in an animal
      model.
PG  - 104-9
LID - 10.1111/j.1460-9592.2010.03497.x [doi]
AB  - BACKGROUND: According to different algorithms of airway management, emergency
      cricothyrotomy is the final step in managing an otherwise not accessible airway. 
      As an alternative to an open surgical procedure, minimally invasive approaches
      exist. Quicktrach baby is a commercially available set for a minimal invasive
      cricothyrotomy in infants. The set consists of a plastic cannula over a metal
      needle for direct placement in the trachea. So far, this device has not been
      evaluated for its intended use. OBJECTIVES: We hypothesize that Quicktrach baby
      allows the establishment of an emergency airway. The aim was to prove that the
      device is easy to handle and the cricothyrotomy fast to perform. METHODS: After
      approval of the local ethics committee, the study was performed on the cadavers
      of 10 adult rabbits. Cricothyrotomy was performed with Quicktrach baby.
      Successful placement, performance time, and complication rate were documented.
      Possible ventilation with a breathing bag was evaluated. Data are reported as
      mean and interquartile range. RESULTS: Successful placement of Quicktrach baby
      was possible in all attempts. The placement took 31 [23-43] s. In two cases, a
      fracture of the cricoid's cartilage was seen. In one animal, damage to the
      posterior wall mucosa was observed. In all cases, sufficient ventilation was
      possible. CONCLUSIONS: Quicktrach baby proved to be a reliable technique. In the 
      animal model, it is easy and fast to perform. Only a few minor complications
      occurred. Sufficient ventilation was possible in all attempts.
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Metterlein, T
AU  - Metterlein T
AD  - Department of Anaesthesiology, University Hospital Regensburg, Regensburg,
      Germany. tom.metterlein@gmx.net
FAU - Frommer, M
AU  - Frommer M
FAU - Kwok, P
AU  - Kwok P
FAU - Lyer, S
AU  - Lyer S
FAU - Graf, B M
AU  - Graf BM
FAU - Sinner, B
AU  - Sinner B
LA  - eng
PT  - Journal Article
PL  - France
TA  - Paediatr Anaesth
JT  - Paediatric anaesthesia
JID - 9206575
SB  - IM
MH  - Airway Management/*instrumentation
MH  - Animals
MH  - Catheters
MH  - Cricoid Cartilage/*surgery
MH  - Disease Models, Animal
MH  - *Emergency Medical Services
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Laryngeal Muscles/*surgery
MH  - Larynx/surgery
MH  - Needles
MH  - Rabbits
MH  - Respiration, Artificial
MH  - Thyroid Cartilage/*surgery
MH  - Trachea/surgery
EDAT- 2011/01/08 06:00
MHDA- 2011/05/05 06:00
CRDT- 2011/01/08 06:00
PHST- 2011/01/08 06:00 [entrez]
PHST- 2011/01/08 06:00 [pubmed]
PHST- 2011/05/05 06:00 [medline]
AID - 10.1111/j.1460-9592.2010.03497.x [doi]
PST - ppublish
SO  - Paediatr Anaesth. 2011 Feb;21(2):104-9. doi: 10.1111/j.1460-9592.2010.03497.x.


PMID- 21210867
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20110311
IS  - 1432-2277 (Electronic)
IS  - 0934-0874 (Linking)
VI  - 24
IP  - 4
DP  - 2011 Apr
TI  - How to increase living donation.
PG  - 344-9
LID - 10.1111/j.1432-2277.2010.01212.x [doi]
AB  - Living donation is the key to increasing access to successful solid organ
      transplantation worldwide. However, the means to expanding the number of living
      donors on a global scale are not known. Although there have been many suggestions
      for the best approach, cultural issues may limit the effectiveness of some
      strategies. Only a few ideas have been studied, and one in particular- outright
      payment to donors - may raise ethical issues that are difficult to surmount and
      might negatively alter altruistic behavior. With respect to the present
      environment, this article will describe some of the approaches that are being
      discussed to increase the number of living donors, with a particular focus on
      kidney transplantation.
CI  - (c) 2011 The Author. Transplant International (c) 2011 European Society for Organ
      Transplantation.
FAU - Davis, Connie L
AU  - Davis CL
AD  - Division of Nephrology, Department of Medicine, School of Medicine, University of
      Washington, Seattle, WA 98195, USA. cdavis@nephrology.washington.edu
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110106
PL  - Switzerland
TA  - Transpl Int
JT  - Transplant international : official journal of the European Society for Organ
      Transplantation
JID - 8908516
SB  - IM
MH  - Altruism
MH  - Health Education
MH  - Humans
MH  - Kidney Failure, Chronic/surgery
MH  - Kidney Transplantation/economics
MH  - Living Donors/*supply & distribution
MH  - Motivation
MH  - Risk
MH  - *Tissue and Organ Procurement/economics
EDAT- 2011/01/08 06:00
MHDA- 2011/06/29 06:00
CRDT- 2011/01/08 06:00
PHST- 2011/01/08 06:00 [entrez]
PHST- 2011/01/08 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
AID - 10.1111/j.1432-2277.2010.01212.x [doi]
PST - ppublish
SO  - Transpl Int. 2011 Apr;24(4):344-9. doi: 10.1111/j.1432-2277.2010.01212.x. Epub
      2011 Jan 6.


PMID- 21210863
OWN - NLM
STAT- MEDLINE
DCOM- 20110628
LR  - 20220317
IS  - 1432-2277 (Electronic)
IS  - 0934-0874 (Linking)
VI  - 24
IP  - 4
DP  - 2011 Apr
TI  - Spanish experience as a leading country: what kind of measures were taken?
PG  - 333-43
LID - 10.1111/j.1432-2277.2010.01204.x [doi]
AB  - A recent call for self-sufficiency in transplantation issued by the WHO faces
      variable worldwide activity, in which Spain occupies a privileged position, with 
      deceased donation rates of 33-35per million population (pmp) and 85 transplants
      pmp. An evaluation of current challenges, including a decrease in deaths because 
      of traffic accidents and cerebrovascular diseases, and a diversity of cultures in
      Spain, has been followed by a comprehensive strategy to increase organ
      availability. Actions include an earlier referral of possible donors to the
      transplant coordination teams, a benchmarking project to identify critical
      success factors in donation after brain death, new family approach and care
      methods, and the development of additional training courses aimed at specific
      groups of professionals, supported by their corresponding societies. Consensus
      documents to improve knowledge about safety limits for organ donation have been
      developed to minimize inappropriate discarding of organs. Use of organs from
      expanded criteria donors under an 'old for old' allocation policy has resulted
      from adaptation to the progressive decline of optimal organs. National strategic 
      plans to deal better with organ shortage, while respecting solid ethical
      standards, are essential, as reflected in the WHO Guiding Principles and the
      Istanbul Declaration on Organ Trafficking and Transplant tourism.
CI  - (c) 2011 The Authors. Transplant International (c) 2011 European Society for
      Organ Transplantation.
FAU - Matesanz, Rafael
AU  - Matesanz R
AD  - Organizacion Nacional de Trasplantes, Madrid, Spain. rmatesanz@msps.es
FAU - Dominguez-Gil, Beatriz
AU  - Dominguez-Gil B
FAU - Coll, Elisabeth
AU  - Coll E
FAU - de la Rosa, Gloria
AU  - de la Rosa G
FAU - Marazuela, Rosario
AU  - Marazuela R
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110106
PL  - Switzerland
TA  - Transpl Int
JT  - Transplant international : official journal of the European Society for Organ
      Transplantation
JID - 8908516
SB  - IM
MH  - Accidents, Traffic/mortality
MH  - Brain Death
MH  - Death
MH  - Humans
MH  - Living Donors/supply & distribution
MH  - Organ Transplantation/*statistics & numerical data
MH  - Spain/epidemiology
MH  - Tissue Donors/supply & distribution
MH  - Tissue and Organ Procurement/organization & administration/*statistics &
      numerical data
EDAT- 2011/01/08 06:00
MHDA- 2011/06/29 06:00
CRDT- 2011/01/08 06:00
PHST- 2011/01/08 06:00 [entrez]
PHST- 2011/01/08 06:00 [pubmed]
PHST- 2011/06/29 06:00 [medline]
AID - 10.1111/j.1432-2277.2010.01204.x [doi]
PST - ppublish
SO  - Transpl Int. 2011 Apr;24(4):333-43. doi: 10.1111/j.1432-2277.2010.01204.x. Epub
      2011 Jan 6.


PMID- 21210760
OWN - NLM
STAT- MEDLINE
DCOM- 20110705
LR  - 20211203
IS  - 1937-3376 (Electronic)
IS  - 1937-3368 (Linking)
VI  - 17
IP  - 2
DP  - 2011 Apr
TI  - Prospects of induced pluripotent stem cell technology in regenerative medicine.
PG  - 115-24
LID - 10.1089/ten.TEB.2010.0549 [doi]
AB  - Induced pluripotent stem (iPS) cells are derived from adult somatic cells via
      reprogramming with ectopic expression of four transcription factors (Oct3/4,
      Sox2, c-Myc and Klf4; or, Oct3/4, Sox2, Nanog, and Lin28), by which the resultant
      cells regain pluripotency, namely, the capability exclusively possessed by some
      embryonic cells to differentiate into any cell lineage under proper conditions.
      Given the ease in cell sourcing and a waiver of ethical opponency, iPS cells
      excel embryonic pluripotent cells in the practice of drug discovery and
      regenerative medicine. With an ex vivo practice in regenerative medicine, many
      problems involved in conventional medicine dosing, such as immune rejection,
      could be potentially circumvented. In this article, we briefly summarize the
      fundamentals and status quo of iPS-related applications, and emphasize the
      prospects of iPS technology in regenerative medicine.
FAU - Zhang, Feng
AU  - Zhang F
AD  - Division of Bioengineering, School of Chemical and Biomedical Engineering,
      Nanyang Technological University. Singapore, Singapore.
FAU - Citra, Fudiman
AU  - Citra F
FAU - Wang, Dong-An
AU  - Wang DA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110215
PL  - United States
TA  - Tissue Eng Part B Rev
JT  - Tissue engineering. Part B, Reviews
JID - 101466660
SB  - IM
MH  - Animals
MH  - Cell Culture Techniques/methods
MH  - Cell Differentiation
MH  - Cell Lineage
MH  - Ectoderm/physiology
MH  - Embryonic Stem Cells/cytology
MH  - Endoderm/physiology
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*cytology
MH  - Kruppel-Like Factor 4
MH  - Mesoderm/physiology
MH  - Mice
MH  - Regeneration
MH  - Regenerative Medicine/*methods
EDAT- 2011/01/08 06:00
MHDA- 2011/07/06 06:00
CRDT- 2011/01/08 06:00
PHST- 2011/01/08 06:00 [entrez]
PHST- 2011/01/08 06:00 [pubmed]
PHST- 2011/07/06 06:00 [medline]
AID - 10.1089/ten.TEB.2010.0549 [doi]
PST - ppublish
SO  - Tissue Eng Part B Rev. 2011 Apr;17(2):115-24. doi: 10.1089/ten.TEB.2010.0549.
      Epub 2011 Feb 15.


PMID- 21209062
OWN - NLM
STAT- MEDLINE
DCOM- 20110201
LR  - 20211020
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 342
DP  - 2011 Jan 5
TI  - Efficacy and safety of scorpion antivenom plus prazosin compared with prazosin
      alone for venomous scorpion (Mesobuthus tamulus) sting: randomised open label
      clinical trial.
PG  - c7136
LID - 10.1136/bmj.c7136 [doi]
LID - bmj.c7136 [pii]
AB  - OBJECTIVE: Envenomation by Mesobuthus tamulus scorpion sting can result in
      serious cardiovascular effects. Scorpion antivenom is a specific treatment for
      scorpion sting. Evidence for the benefit of scorpion antivenom and its efficacy
      compared with that of commonly used vasodilators, such as prazosin, is scarce. We
      assessed the efficacy of prazosin combined with scorpion antivenom, compared with
      prazosin alone, in individuals with autonomic storm caused by scorpion sting.
      DESIGN: Prospective, open label randomised controlled trial. SETTING: General
      hospital inpatients (Bawaskar Hospital and Research Centre Mahad Dist-Raigad
      Maharashtra, India). PARTICIPANTS: Seventy patients with grade 2 scorpion
      envenomation, older than six months, with no cardiorespiratory or central nervous
      system abnormalities. INTERVENTION: Scorpion antivenom plus prazosin (n=35) or
      prazosin alone (n=35) assigned by block randomisation. Treatment was not masked. 
      Analysis was by intention to treat. MAIN OUTCOME MEASURES: The primary end point 
      was the proportion of patients achieving resolution of the clinical syndrome
      (sweating, salivation, cool extremities, priapism, hypertension or hypotension,
      tachycardia) 10 hours after administration of study drugs. Secondary end points
      were time required for complete resolution of clinical syndrome, prevention of
      deterioration to higher grade, doses of prazosin required overall and within 10
      hours, and adverse events. The study protocol was approved by the independent
      ethics committee of Mumbai. RESULTS: Mean (SD) recovery times in hours for the
      prazosin plus scorpion antivenom group compared with the prazosin alone groups
      were: sweating 3 (1.1) v 6.6 (2.6); salivation 1.9 (0.9) v 3 (1.9); priapism 4.7 
      (1.5) v 9.4 (1.5). Mean (SD) doses of prazosin in the groups were 2 (2.3) and 4
      (3.5), respectively. 32 patients (91.4%, 95% confidence interval 76.9% to 97.8%) 
      in the prazosin plus antivenom group showed complete resolution of the clinical
      syndrome within 10 hours of administration of treatment compared with eight
      patients in the prazosin group (22.9%, 11.8% to 39.3%). Patients from the
      antivenom plus prazosin group recovered earlier (mean 8 hours, 95% CI 6.5 to 9.5)
      than those in the control group (17.7 hours, 15.4 to 19.9; mean difference -9.7
      hours, -6.9 to -12.4). The number of patients whose condition deteriorated to a
      higher grade was similar in both groups (antivenom plus prazosin four of 35,
      prazosin alone five of 35). Hypotension was reported in fewer patients in the
      antivenom plus prazosin group (12 of 35, 34.3%) than in the prazosin group (19 of
      35, 54.3%), but the difference was not statistically significant. No difference
      was noted in change in blood pressure and pulse rate over time between two
      groups. CONCLUSION: Recovery from scorpion sting is hastened by simultaneous
      administration of scorpion antivenom plus prazosin compared with prazosin alone. 
      TRIAL REGISTRATION NUMBER: CTRI/2010/091/000584 (Clinical Trials Registry India).
FAU - Bawaskar, Himmatrao Saluba
AU  - Bawaskar HS
AD  - Bawaskar Hospital and Research Centre, Mahad, Dist-Raigad, Maharashtra, India
      402301. himmatbawaskar@rediffmail.com
FAU - Bawaskar, Pramodini Himmatrao
AU  - Bawaskar PH
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
DEP - 20110105
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
RN  - 0 (Adrenergic alpha-1 Receptor Antagonists)
RN  - 0 (Antivenins)
RN  - 0 (Drug Combinations)
RN  - 0 (Immunologic Factors)
RN  - 0 (Scorpion Venoms)
RN  - XM03YJ541D (Prazosin)
SB  - IM
CIN - BMJ. 2011;342:c7369. PMID: 21209063
MH  - Administration, Oral
MH  - Adolescent
MH  - Adrenergic alpha-1 Receptor Antagonists/*administration & dosage/adverse effects
MH  - Adult
MH  - Animals
MH  - Antivenins/*administration & dosage/adverse effects
MH  - Child
MH  - Child, Preschool
MH  - Drug Combinations
MH  - Female
MH  - Humans
MH  - Immunologic Factors/*administration & dosage/adverse effects
MH  - Infant
MH  - Infusions, Intravenous
MH  - Male
MH  - Prazosin/*administration & dosage/adverse effects
MH  - Scorpion Stings/*drug therapy
MH  - *Scorpion Venoms
MH  - Scorpions
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC3016167
EDAT- 2011/01/07 06:00
MHDA- 2011/02/02 06:00
CRDT- 2011/01/07 06:00
PHST- 2011/01/07 06:00 [entrez]
PHST- 2011/01/07 06:00 [pubmed]
PHST- 2011/02/02 06:00 [medline]
AID - 10.1136/bmj.c7136 [doi]
PST - epublish
SO  - BMJ. 2011 Jan 5;342:c7136. doi: 10.1136/bmj.c7136.


PMID- 21208451
OWN - NLM
STAT- MEDLINE
DCOM- 20110307
LR  - 20211020
IS  - 1471-2458 (Electronic)
IS  - 1471-2458 (Linking)
VI  - 11
DP  - 2011 Jan 5
TI  - The Cool Little Kids randomised controlled trial: population-level early
      prevention for anxiety disorders.
PG  - 11
LID - 10.1186/1471-2458-11-11 [doi]
AB  - BACKGROUND: The World Health Organization predicts that by 2030 internalising
      problems (e.g. depression and anxiety) will be second only to HIV/AIDS in
      international burden of disease. Internalising problems affect 1 in 7 school aged
      children, impacting on peer relations, school engagement, and later mental
      health, relationships and employment. The development of early childhood
      prevention for internalising problems is in its infancy. The current study
      follows two successful 'efficacy' trials of a parenting group intervention to
      reduce internalising disorders in temperamentally inhibited preschool children.
      Cool Little Kids is a population-level randomised trial to determine the impacts 
      of systematically screening preschoolers for inhibition then offering a parenting
      group intervention, on child internalising problems and economic costs at school 
      entry. METHODS/DESIGN: This randomised trial will be conducted within the
      preschool service system, attended by more than 95% of Australian children in the
      year before starting school. In early 2011, preschool services in four local
      government areas in Melbourne, Australia, will distribute the screening tool. The
      approximately 16% (n approximately 500) with temperamental inhibition will enter 
      the trial. Intervention parents will be offered Cool Little Kids, a 6-session
      group program in the local community, focusing on ways to develop their child's
      bravery skills by reducing overprotective parenting interactions. Outcomes one
      and two years post-baseline will comprise child internalising diagnoses and
      symptoms, parenting interactions, and parent wellbeing. An economic evaluation
      (cost-consequences framework) will compare incremental differences in costs of
      the intervention versus control children to incremental differences in outcomes, 
      from a societal perspective. Analyses will use the intention-to-treat principle, 
      using logistic and linear regression models (binary and continuous outcomes
      respectively) to compare outcomes between the trial arms. DISCUSSION: This trial 
      addresses gaps for internalising problems identified in the 2004 World Health
      Organization Prevention of Mental Disorders report. If effective and
      cost-effective, the intervention could readily be applied at a population level. 
      Governments consider mental health to be a priority, enhancing the likelihood
      that an effective early prevention program would be adopted in Australia and
      internationally. RCH HUMAN RESEARCH ETHICS APPROVAL: 30105A.
FAU - Bayer, Jordana K
AU  - Bayer JK
AD  - Department of Pediatrics, The University of Melbourne, Parkville, Australia.
      jbayer@unimelb.edu.au
FAU - Rapee, Ronald M
AU  - Rapee RM
FAU - Hiscock, Harriet
AU  - Hiscock H
FAU - Ukoumunne, Obioha C
AU  - Ukoumunne OC
FAU - Mihalopoulos, Cathrine
AU  - Mihalopoulos C
FAU - Clifford, Susan
AU  - Clifford S
FAU - Wake, Melissa
AU  - Wake M
LA  - eng
SI  - ISRCTN/ISRCTN30996662
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110105
PL  - England
TA  - BMC Public Health
JT  - BMC public health
JID - 100968562
SB  - IM
MH  - Anxiety Disorders/diagnosis/*prevention & control
MH  - Australia
MH  - *Child Health Services/economics
MH  - Child, Preschool
MH  - Consent Forms
MH  - Cost-Benefit Analysis
MH  - Data Interpretation, Statistical
MH  - Female
MH  - Health Education
MH  - Humans
MH  - Male
MH  - Mass Screening/economics
MH  - Parenting
MH  - Patient Selection
MH  - Regression Analysis
MH  - Research Design
PMC - PMC3027133
EDAT- 2011/01/07 06:00
MHDA- 2011/03/08 06:00
CRDT- 2011/01/07 06:00
PHST- 2010/12/13 00:00 [received]
PHST- 2011/01/05 00:00 [accepted]
PHST- 2011/01/07 06:00 [entrez]
PHST- 2011/01/07 06:00 [pubmed]
PHST- 2011/03/08 06:00 [medline]
AID - 1471-2458-11-11 [pii]
AID - 10.1186/1471-2458-11-11 [doi]
PST - epublish
SO  - BMC Public Health. 2011 Jan 5;11:11. doi: 10.1186/1471-2458-11-11.


PMID- 21208165
OWN - NLM
STAT- MEDLINE
DCOM- 20120112
LR  - 20191111
IS  - 1875-5739 (Electronic)
IS  - 1567-2026 (Linking)
VI  - 8
IP  - 1
DP  - 2011 Feb
TI  - Transplantation of adipose tissue-derived stem cells for treatment of focal
      cerebral ischemia.
PG  - 1-13
AB  - The neurological functional disabilities caused by cerebral infarction
      significantly deteriorate life quality and increase the medical and
      socio-economic costs. Although some molecular agents show potential in acting
      against the pathological mechanisms in animal studies, none has been proven
      effective for cerebral ischemia treatment in human patients. New treatment
      strategy needs to be developed. Stem cell therapy is promising for neural
      regeneration and thus become one of the current trends. More evidence has shown
      stem cells, such as embryonic stem cells (ESCs), skeletal muscle satellite cells 
      and mesenchymal stem cells, to be useful in tissue repair and regeneration.
      However all these stem cells mentioned above have limitations. Adipose
      tissue-derived stem cells (ADSCs) are an alternative autologous stem cell source 
      for the characters as abundant, easy to obtain, immunological and ethic problem
      free. So far, this treatment strategy has been rarely adopted on ischemic brain
      injury. In this study, we investigated the transplantation effects of rat ADSCs
      for the treatment of cerebral ischemia in rats. ADSCs were isolated from rat
      adipose tissue and then induced to initiate neural differentiation. Following
      neural induction, ADSCs developed neural morphology and displayed molecular
      expression of Nestin, MAP2 and GFAP. We evaluate the neurobehavioral function,
      infarct volume and cell properties as apoptosis, survival, migration,
      proliferation, differentiation and immunogenicity. Treatment with i-ADSCs
      (induction from ADSCs) results in better functional recovery and more reduction
      in hemispheric atrophy then without i-ADSCs in other groups. Our study
      demonstrates that i-ADSCs therapy is promising in stroke treatment and finally
      leads to an efficacious therapeutic modalities for much better outcome in
      clinical patients.
FAU - Yang, Yi-Chin
AU  - Yang YC
AD  - Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan,
      ROC.
FAU - Liu, Bai-Shuan
AU  - Liu BS
FAU - Shen, Chiung-Chyi
AU  - Shen CC
FAU - Lin, Chen-Huan
AU  - Lin CH
FAU - Chiao, Ming-Tsang
AU  - Chiao MT
FAU - Cheng, Hsu-Chen
AU  - Cheng HC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United Arab Emirates
TA  - Curr Neurovasc Res
JT  - Current neurovascular research
JID - 101208439
SB  - IM
MH  - Adipocytes/cytology/*physiology
MH  - Adipose Tissue/cytology/*physiology
MH  - Animals
MH  - Brain Ischemia/pathology/*surgery
MH  - Cell Differentiation/*physiology
MH  - Cells, Cultured
MH  - Male
MH  - Neural Stem Cells/cytology/*physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Stem Cell Transplantation/*methods
EDAT- 2011/01/07 06:00
MHDA- 2012/01/13 06:00
CRDT- 2011/01/07 06:00
PHST- 2010/09/03 00:00 [received]
PHST- 2010/09/19 00:00 [accepted]
PHST- 2011/01/07 06:00 [entrez]
PHST- 2011/01/07 06:00 [pubmed]
PHST- 2012/01/13 06:00 [medline]
AID - BSP/CNR/E-Pub/00035 [pii]
AID - 10.2174/156720211794520215 [doi]
PST - ppublish
SO  - Curr Neurovasc Res. 2011 Feb;8(1):1-13. doi: 10.2174/156720211794520215.


PMID- 21208152
OWN - NLM
STAT- MEDLINE
DCOM- 20110614
LR  - 20181201
IS  - 1473-4877 (Electronic)
IS  - 0300-7995 (Linking)
VI  - 27
IP  - 3
DP  - 2011 Mar
TI  - Informed consent and phase IV non-interventional drug research.
PG  - 513-8
LID - 10.1185/03007995.2010.546393 [doi]
AB  - Most of the literature on informed consent in pharmaceutical drug research works 
      on the assumption that informed consent is something that is homogeneous and thus
      can be rendered procedurally universal. This may be justifiable to a certain
      extent owing to the fact these are all drug trials anyway. Nevertheless, in spite
      of this general similarity, we also know that the clinical drug development
      phases are characteristically different, and that phase IV is very different from
      the other phases because, owing to its postmarketing nature, it is much more
      varied in scope and in type. Thus, it is worthwhile looking into the ethical
      nuances relevant to the informed consent process in phase IV non-interventional
      drug research. We shall deal with the issues on the necessity of informed consent
      for this type of research and then discuss the possibilities for an opt-out
      system. We conclude that informed consent is necessary for non-interventional
      studies, and thus any form of waiving of rights of participants to informed
      consent must have a valid substantial justification. The distinct character of
      phase IV accounts for the difference in content of the informed consent document 
      compared to that of earlier phases, and both opt-in and opt-out procedures are
      ethically justifiable as long as the participant's participation remains informed
      and voluntary.
FAU - Bernabe, Rosemarie D C
AU  - Bernabe RD
FAU - van Thiel, Ghislaine J M W
AU  - van Thiel GJ
FAU - van Delden, Johannes J M
AU  - van Delden JJ
FAU - Raaijmakers, Jan A M
AU  - Raaijmakers JA
LA  - eng
PT  - Editorial
DEP - 20110106
PL  - England
TA  - Curr Med Res Opin
JT  - Current medical research and opinion
JID - 0351014
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Clinical Trials, Phase IV as Topic/*ethics/*methods
MH  - Consent Forms/*statistics & numerical data
MH  - Drug Utilization/*ethics
MH  - Humans
MH  - *Informed Consent/ethics
MH  - Observation
MH  - Personal Autonomy
MH  - Pharmaceutical Preparations/analysis
MH  - Product Surveillance, Postmarketing
MH  - Research
MH  - Risk Assessment
EDAT- 2011/01/07 06:00
MHDA- 2011/06/15 06:00
CRDT- 2011/01/07 06:00
PHST- 2011/01/07 06:00 [entrez]
PHST- 2011/01/07 06:00 [pubmed]
PHST- 2011/06/15 06:00 [medline]
AID - 10.1185/03007995.2010.546393 [doi]
PST - ppublish
SO  - Curr Med Res Opin. 2011 Mar;27(3):513-8. doi: 10.1185/03007995.2010.546393. Epub 
      2011 Jan 6.


PMID- 21207489
OWN - NLM
STAT- MEDLINE
DCOM- 20110506
LR  - 20131121
IS  - 1520-6696 (Electronic)
IS  - 0022-5061 (Linking)
VI  - 47
IP  - 1
DP  - 2011 Winter
TI  - The end of drugging children: toward the genealogy of the ADHD subject.
PG  - 44-69
LID - 10.1002/jhbs.20471 [doi]
AB  - This genealogy of the ADHD subject will demonstrate that over the course of the
      twentieth century a new relation between power, knowledge, the body, and ethical 
      practices of self-formation emerged around the ADHD-type in ways that are not
      captured by the received critical perspective. By examining the history of
      knowledge and practices surrounding the ADHD-type, this work will argue that the 
      deviant subject that was located relative to external institutional
      moral/juridical values or standards is replaced over the course of the century by
      a new intelligibility of rational self-management. A further analysis of this
      emergent intelligibility attempts to advance the critical understanding of the
      increasingly prevalent ADHD phenomenon by showing how novel drug and brain
      imaging technologies work to link behaviors to identity, establishing new
      relations of power to the subject not captured by the received medicalization
      perspective. This work will be of interest to anybody interested in the relations
      among knowledge, drugs, power, and the ADHD subject.
CI  - (c) 2011 Wiley Periodicals, Inc.
FAU - Comstock, Edward J
AU  - Comstock EJ
AD  - Department of Literature, American University, Washington, DC, USA.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - J Hist Behav Sci
JT  - Journal of the history of the behavioral sciences
JID - 18020010R
RN  - 0 (Amphetamines)
RN  - 0 (Central Nervous System Stimulants)
RN  - 207ZZ9QZ49 (Methylphenidate)
SB  - IM
MH  - Amphetamines/history/therapeutic use
MH  - Attention Deficit Disorder with Hyperactivity/drug therapy/*history
MH  - Central Nervous System Stimulants/*history/therapeutic use
MH  - Child
MH  - Child Psychiatry/*history
MH  - Child Welfare
MH  - Health Knowledge, Attitudes, Practice
MH  - History, 20th Century
MH  - Humans
MH  - Methylphenidate/*history/therapeutic use
MH  - Neurosciences/history
MH  - *Psychological Theory
MH  - Social Perception
EDAT- 2011/01/06 06:00
MHDA- 2011/05/07 06:00
CRDT- 2011/01/06 06:00
PHST- 2011/01/06 06:00 [entrez]
PHST- 2011/01/06 06:00 [pubmed]
PHST- 2011/05/07 06:00 [medline]
AID - 10.1002/jhbs.20471 [doi]
PST - ppublish
SO  - J Hist Behav Sci. 2011 Winter;47(1):44-69. doi: 10.1002/jhbs.20471.


PMID- 21207152
OWN - NLM
STAT- MEDLINE
DCOM- 20111201
LR  - 20211020
IS  - 1573-3394 (Electronic)
IS  - 1065-3058 (Linking)
VI  - 19
IP  - 1
DP  - 2011 Mar
TI  - The ethics of care: normative structures and empirical implications.
PG  - 51-64
LID - 10.1007/s10728-010-0163-7 [doi]
AB  - In this article I argue that the ethics of care provides us with a novel reading 
      of human relations, and therefore makes possible a fresh approach to several
      empirical challenges. In order to explore this connection, I discuss some
      specific normative features of the ethics of care--primarily the comprehension of
      the moral agent and the concept of care--as these two key elements contribute
      substantially to a new ethical outlook. Subsequently, I argue that the relational
      and reciprocal mode of thinking with regard to the moral agent must be extended
      to our understanding of care. I term this comprehension "mature care". Citing
      conflicts of interests as examples, I demonstrate how this conceptualization of
      care may further advance the ethics of care's ability to take on empirical
      challenges. Finally, I discuss political implications that may emanate from the
      ethics of care and the concept of mature care.
FAU - Pettersen, Tove
AU  - Pettersen T
AD  - Department of Philosophy, Classics, History of Art and Ideas, Faculty of
      Humanities, University of Oslo, PO Box 1020, Blindern, 0315 Oslo, Norway.
      tove.pettersen@ifikk.uio.no
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Health Care Anal
JT  - Health care analysis : HCA : journal of health philosophy and policy
JID - 9432537
MH  - Delivery of Health Care/*ethics
MH  - *Ethical Analysis
MH  - Ethical Theory
MH  - Humans
MH  - Morals
PMC - PMC3037474
EDAT- 2011/01/06 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/01/06 06:00
PHST- 2011/01/06 06:00 [entrez]
PHST- 2011/01/06 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/s10728-010-0163-7 [doi]
PST - ppublish
SO  - Health Care Anal. 2011 Mar;19(1):51-64. doi: 10.1007/s10728-010-0163-7.


PMID- 21206998
OWN - NLM
STAT- MEDLINE
DCOM- 20110517
LR  - 20110128
IS  - 1433-0407 (Electronic)
IS  - 0028-2804 (Linking)
VI  - 82
IP  - 1
DP  - 2011 Jan
TI  - [Significance of a recent amendment on advance directives for psychiatric
      patients in Germany].
PG  - 57-66
LID - 10.1007/s00115-010-3206-2 [doi]
AB  - Current legal regulations concerning the right of self-determination of subjects 
      who are not competent to give consent have been in force since 2009. According to
      the new regulations, such subjects can exercise their right of self-determination
      through a legal guardian who will assess and impose their will. If there is an
      operative advance directive covering the specific case, the guardian is bound by 
      the provisions laid down in it. Although primarily intended for end-of-life
      decisions, the law applies in all cases of a subject's inability to give consent,
      including the context of mental illness. It allows the persons concerned to
      define certain aspects of medical treatment in advance. On the one hand, the
      right of self-determination of mentally ill people is thus strengthened. On the
      other hand, the new regulations can also cause significant ethical conflict
      involving patients and their representatives as well as family members and
      practitioners. The present contribution presents the consequences of the
      amendment for the treatment of mentally ill people. Case studies are described in
      order to illustrate the new regulations in clinical situations.
FAU - Grozinger, M
AU  - Grozinger M
AD  - Klinik fur Psychiatrie, Psychotherapie und Psychosomatik, Univesitatsklinikum
      Aachen, Aachen, Germany. mgroezinger@ukaachen.de
FAU - Olzen, D
AU  - Olzen D
FAU - Metzmacher, A
AU  - Metzmacher A
FAU - Podoll, K
AU  - Podoll K
FAU - Schneider, F
AU  - Schneider F
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Patientenverfugungsgesetz. Konsequenzen fur die Behandlung psychisch Kranker.
PL  - Germany
TA  - Nervenarzt
JT  - Der Nervenarzt
JID - 0400773
SB  - IM
MH  - Germany
MH  - Humans
MH  - Informed Consent/*legislation & jurisprudence
MH  - *Mental Disorders
MH  - *Personal Autonomy
MH  - *Physician-Patient Relations
MH  - Sleep Phase Chronotherapy/*legislation & jurisprudence
EDAT- 2011/01/06 06:00
MHDA- 2011/05/18 06:00
CRDT- 2011/01/06 06:00
PHST- 2011/01/06 06:00 [entrez]
PHST- 2011/01/06 06:00 [pubmed]
PHST- 2011/05/18 06:00 [medline]
AID - 10.1007/s00115-010-3206-2 [doi]
PST - ppublish
SO  - Nervenarzt. 2011 Jan;82(1):57-66. doi: 10.1007/s00115-010-3206-2.


PMID- 21206275
OWN - NLM
STAT- MEDLINE
DCOM- 20110610
LR  - 20181201
IS  - 1365-2346 (Electronic)
IS  - 0265-0215 (Linking)
VI  - 28
IP  - 3
DP  - 2011 Mar
TI  - The end-tidal desflurane concentration for smooth removal of the laryngeal mask
      airway in anaesthetised adults.
PG  - 187-9
LID - 10.1097/EJA.0b013e3283433b83 [doi]
AB  - BACKGROUND AND OBJECTIVE: The end-tidal desflurane concentration required for
      smooth removal of the laryngeal mask airway (LMA) has not been established.
      Therefore, we aimed to find the end-tidal desflurane concentration for safe,
      smooth, and uncomplicated LMA removal. METHODS: The study was approved by the
      Ethical Committee of the Ministry of Health, Diskapi Yildirim Beyazit Research
      and the Training Hospital, Ankara, Turkey. All patients provided written consent.
      A total of 23 adults, 18-60 years of age and American Society of
      Anesthesiologists physical status class I, who had been scheduled for urological 
      surgery were included in the study. The intravenous induction of anaesthesia was 
      performed with propofol 2.5 mg kg(-)(1) and remifentanil 10 mug within 30 s. The 
      LMA was inserted. Maintenance of anaesthesia was provided by desflurane, with
      nitrous oxide and oxygen. The LMA was removed at predetermined end-tidal
      desflurane concentrations at the end of surgery. The concentration at which LMA
      removal was attempted was determined by Dixon's up-down method with 0.5% as the
      step size. When LMA removal was accomplished without coughing, teeth clenching,
      gross purposeful movements, breath holding, laryngospasm, and desaturation to
      SpO(2) less than 90%, it was considered a smooth (successful) removal. RESULTS:
      For smooth removal of the LMA, end-tidal desflurane EC50 was 2.1% [95% confidence
      interval (CI) 1.1-2.9%], and the EC95 value was 3.9% (95% CI 3.1-7.9%).
      CONCLUSION: The EC95 of end-tidal desflurane for the smooth removal of the LMA is
      3.9%. LMA removal in adults receiving desflurane may be possible at approximately
      0.7 minimum alveolar concentration.
FAU - Sahiner, Yeliz
AU  - Sahiner Y
AD  - Department of Anesthesiology, Ministry of Health Diskapi Yildirim Beyazit
      Training and Research Hospital, Ankara, Turkey.
FAU - Ozkan, Derya
AU  - Ozkan D
FAU - Akkaya, Taylan
AU  - Akkaya T
FAU - Goral, Nilgun
AU  - Goral N
FAU - Alptekin, Alp
AU  - Alptekin A
FAU - Gumus, Haluk
AU  - Gumus H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur J Anaesthesiol
JT  - European journal of anaesthesiology
JID - 8411711
RN  - 0 (Anesthetics, Inhalation)
RN  - 0 (Anesthetics, Intravenous)
RN  - 0 (Piperidines)
RN  - CRS35BZ94Q (Desflurane)
RN  - CYS9AKD70P (Isoflurane)
RN  - P10582JYYK (Remifentanil)
RN  - YI7VU623SF (Propofol)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Anesthetics, Inhalation/*pharmacokinetics
MH  - Anesthetics, Intravenous/administration & dosage
MH  - Desflurane
MH  - Device Removal
MH  - Female
MH  - Humans
MH  - Intubation, Intratracheal/*methods
MH  - Isoflurane/*analogs & derivatives/pharmacokinetics
MH  - *Laryngeal Masks
MH  - Male
MH  - Middle Aged
MH  - Piperidines/administration & dosage
MH  - Propofol/administration & dosage
MH  - Remifentanil
MH  - Urologic Surgical Procedures/methods
MH  - Young Adult
EDAT- 2011/01/06 06:00
MHDA- 2011/06/11 06:00
CRDT- 2011/01/06 06:00
PHST- 2011/01/06 06:00 [entrez]
PHST- 2011/01/06 06:00 [pubmed]
PHST- 2011/06/11 06:00 [medline]
AID - 10.1097/EJA.0b013e3283433b83 [doi]
PST - ppublish
SO  - Eur J Anaesthesiol. 2011 Mar;28(3):187-9. doi: 10.1097/EJA.0b013e3283433b83.


PMID- 21206112
OWN - NLM
STAT- MEDLINE
DCOM- 20110608
LR  - 20151221
IS  - 0972-2823 (Electronic)
IS  - 0022-3859 (Linking)
VI  - 57
IP  - 1
DP  - 2011 Jan-Mar
TI  - Reporting of the methodological quality and ethical aspects in clinical trials
      published in Indian journals: a survey.
PG  - 82-3
LID - 10.4103/0022-3859.74300 [doi]
CN  - Jaykaran
FAU - Kantharia, N D
AU  - Kantharia ND
FAU - Yadav, P
AU  - Yadav P
FAU - Deoghare, S
AU  - Deoghare S
LA  - eng
PT  - Letter
PL  - India
TA  - J Postgrad Med
JT  - Journal of postgraduate medicine
JID - 2985196R
SB  - IM
MH  - Biomedical Research/ethics/standards
MH  - *Clinical Trials as Topic/ethics/methods/standards
MH  - Guideline Adherence/ethics
MH  - Humans
MH  - Periodicals as Topic/*standards
MH  - Publishing/ethics/standards
MH  - Quality Control
MH  - Research Design/*standards
EDAT- 2011/01/06 06:00
MHDA- 2011/06/09 06:00
CRDT- 2011/01/06 06:00
PHST- 2011/01/06 06:00 [entrez]
PHST- 2011/01/06 06:00 [pubmed]
PHST- 2011/06/09 06:00 [medline]
AID - 74300 [pii]
AID - 10.4103/0022-3859.74300 [doi]
PST - ppublish
SO  - J Postgrad Med. 2011 Jan-Mar;57(1):82-3. doi: 10.4103/0022-3859.74300.


PMID- 21205725
OWN - NLM
STAT- MEDLINE
DCOM- 20110131
LR  - 20220330
IS  - 1930-7837 (Electronic)
IS  - 0022-0337 (Linking)
VI  - 75
IP  - 1
DP  - 2011 Jan
TI  - Developing a Self-Scoring Comprehensive Instrument to Measure Rest's
      Four-Component Model of Moral Behavior: The Moral Skills Inventory.
PG  - 23-35
AB  - One of the most extensively studied constructs in dental education is the
      four-component model of moral behavior proposed by James Rest and the set of
      instruments for measuring it developed by Rest, Muriel Bebeau, and others.
      Although significant associations have been identified between the four
      components Rest proposed (called here Moral Sensitivity, Moral Reasoning, Moral
      Integrity, and Moral Courage) and dental ethics courses and practitioners with
      disciplined licenses, there is no single instrument that measures all four
      components, and existing single component instruments require professional
      scoring. This article describes the development and validation of a short,
      self-scoring instrument, the Moral Skills Inventory, that measures all four
      components. Evidence of face validity, test/retest reliability, and concurrent
      convergent and divergent predictive validity are demonstrated in three
      populations: dental students, clinical dental faculty members, and regents and
      officers of the American College of Dentists. Significant issues remain in
      developing the Rest four-component model for use in dental education and
      practice. Specifically, further construct validation research is needed to
      understand the nature of the components. In particular, it remains undetermined
      whether moral constructs are characteristics of individuals that drive behavior
      in specific situations or whether particular patterns of moral behavior learned
      and used in response to individual circumstances are summarized by researchers
      and then imputed to practitioners.
FAU - Chambers, David W
AU  - Chambers DW
AD  - Arthur A. Dugoni School of Dentistry, University of the Pacific, 2155 Webster
      Street, San Francisco, CA 94115, USA. dchambers@pacific.edu
LA  - eng
PT  - Journal Article
PT  - Validation Study
PL  - United States
TA  - J Dent Educ
JT  - Journal of dental education
JID - 8000150
SB  - IM
MH  - Artificial Intelligence
MH  - Education, Dental/methods
MH  - Ethical Analysis
MH  - Ethics, Dental/*education
MH  - Humans
MH  - Models, Psychological
MH  - Moral Development
MH  - *Self-Evaluation Programs
EDAT- 2011/01/06 06:00
MHDA- 2011/02/01 06:00
CRDT- 2011/01/06 06:00
PHST- 2011/01/06 06:00 [entrez]
PHST- 2011/01/06 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
AID - 75/1/23 [pii]
PST - ppublish
SO  - J Dent Educ. 2011 Jan;75(1):23-35.


PMID- 21205297
OWN - NLM
STAT- MEDLINE
DCOM- 20110509
LR  - 20211203
IS  - 1479-5876 (Electronic)
IS  - 1479-5876 (Linking)
VI  - 9
DP  - 2011 Jan 4
TI  - Translational Medicine is developing in China: a new venue for collaboration.
PG  - 3
LID - 10.1186/1479-5876-9-3 [doi]
AB  - Translational Medicine is an emerging area comprising multidisciplinary Research 
      from basic sciences to medical applications well summarized by the
      Bench-to-Beside concept; this entails close collaboration between clinicians and 
      basic scientists across institutes. We further clarified that Translational
      Medicine should be regarded as a two-way road: Bench-to-Bedside and
      Bedside-to-Bench, to complement testing of novel therapeutic strategies in humans
      with feedback understanding of how they respond to them. It is, therefore,
      critical and important to define and promote Translational Medicine among
      clinicians, basic Researchers, biotechnologists, politicians, ethicists,
      sociologists, investors and coordinate these efforts among different Countries,
      fostering aspects germane only to this type of Research such as, as recently
      discussed, biotechnology entrepreneurship. Translational Medicine as an
      inter-disciplinary science is developing rapidly and widely and, in this article,
      we will place a special emphasis on China.
FAU - Wang, Xiangdong
AU  - Wang X
AD  - Department of Respiratory Medicine, Biomedical Research Center, Fudan University 
      Zhongshan Hospital, Shanghai, PR China. xiangdong.wang@telia.com
FAU - Wang, Ena
AU  - Wang E
FAU - Marincola, Francesco M
AU  - Marincola FM
LA  - eng
PT  - Editorial
DEP - 20110104
PL  - England
TA  - J Transl Med
JT  - Journal of translational medicine
JID - 101190741
SB  - IM
MH  - China
MH  - Communication
MH  - *Cooperative Behavior
MH  - Developing Countries
MH  - Editorial Policies
MH  - Humans
MH  - Medicine/*trends
MH  - Publishing/legislation & jurisprudence
MH  - Translational Research, Biomedical/methods/*trends
PMC - PMC3023702
EDAT- 2011/01/06 06:00
MHDA- 2011/05/10 06:00
CRDT- 2011/01/06 06:00
PHST- 2010/12/17 00:00 [received]
PHST- 2011/01/04 00:00 [accepted]
PHST- 2011/01/06 06:00 [entrez]
PHST- 2011/01/06 06:00 [pubmed]
PHST- 2011/05/10 06:00 [medline]
AID - 1479-5876-9-3 [pii]
AID - 10.1186/1479-5876-9-3 [doi]
PST - epublish
SO  - J Transl Med. 2011 Jan 4;9:3. doi: 10.1186/1479-5876-9-3.


PMID- 21204796
OWN - NLM
STAT- MEDLINE
DCOM- 20120405
LR  - 20111213
IS  - 1399-0004 (Electronic)
IS  - 0009-9163 (Linking)
VI  - 81
IP  - 1
DP  - 2012 Jan
TI  - Adoption and the communication of genetic risk: experiences in Huntington
      disease.
PG  - 64-9
LID - 10.1111/j.1399-0004.2010.01614.x [doi]
AB  - Adoption agencies can use genetic information to determine the eligibility of
      prospective adoptive parents and to establish a child's suitability for adoption.
      We describe experiences and implications of communicating genetic risk for
      Huntington disease (HD) in the context of adoption. A secondary analysis was
      employed using data collected from a cross-sectional survey (n = 233) and two
      qualitative studies on the psychosocial effects of predictive testing for HD. We 
      demonstrate several ethical and practical challenges in the search for and
      communication of genetic information for adoptees and their birth relatives. We
      also found that concern for adoption discrimination was reported by 13.7% of
      survey respondents (n = 32). Concerns were higher among tested respondents than
      those who had not been tested (n = 29 vs n = 3, p = 0.010). However, more
      respondents were concerned about being discriminated based on their family
      history (FHx) vs their genetic test results (GTR) (concern based on FHx: n = 18
      vs based on GTR: n = 1 vs based on both: n =10). These findings contribute to the
      limited empirical literature by offering evidence on the experiences and
      implications of communicating genetic risk information in the context of adoption
      with reference to HD.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Bombard, Y
AU  - Bombard Y
AD  - Department of Medical Genetics, University of British Columbia, Vancouver, BC,
      V5Z 4H4 Canada. bombardy@mskcc.org
FAU - Semaka, A
AU  - Semaka A
FAU - Hayden, M R
AU  - Hayden MR
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110109
PL  - Denmark
TA  - Clin Genet
JT  - Clinical genetics
JID - 0253664
SB  - IM
MH  - Adoption/*psychology
MH  - Genetic Predisposition to Disease/genetics/*psychology
MH  - Genetic Privacy/ethics
MH  - Genetic Testing/*ethics
MH  - Humans
MH  - Huntington Disease/diagnosis/*genetics/psychology
MH  - Risk Factors
EDAT- 2011/01/06 06:00
MHDA- 2012/04/06 06:00
CRDT- 2011/01/06 06:00
PHST- 2011/01/06 06:00 [entrez]
PHST- 2011/01/06 06:00 [pubmed]
PHST- 2012/04/06 06:00 [medline]
AID - 10.1111/j.1399-0004.2010.01614.x [doi]
PST - ppublish
SO  - Clin Genet. 2012 Jan;81(1):64-9. doi: 10.1111/j.1399-0004.2010.01614.x. Epub 2011
      Jan 9.


PMID- 21204795
OWN - NLM
STAT- MEDLINE
DCOM- 20110802
LR  - 20151119
IS  - 1399-0004 (Electronic)
IS  - 0009-9163 (Linking)
VI  - 79
IP  - 5
DP  - 2011 May
TI  - Personalized medicine - the promised land: are we there yet?
PG  - 403-12
LID - 10.1111/j.1399-0004.2010.01609.x [doi]
AB  - The delivery of personalized genomic medicine (refer Table 1 for a comparison of 
      genomic vs genetic medicine and box 1 for glossary) hinges on obtaining personal 
      genomic data through genome-wide association studies (GWAS) or whole-genome
      sequencing. After the completion of the human genome project (see box 2 for human
      genome projects and its derivative projects) in 2003, there appeared to be a
      period of euphoric optimism that as soon as the cost of sequencing the whole
      human genome could be brought down to an affordable range, the promise of
      personalized medicine would become a reality. However, inasmuch as the miraculous
      technological advancements are making whole-genome data acquisition an
      inexpensive reality, we are also starting to appreciate that making sense of the 
      enormous amount of genomic data is a far bigger hurdle. Issues, both scientific
      and ethico-legal, will have to be addressed as genomic data are been pushed for
      clinical and direct-to-consumer utilization. [Table: see text].
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Li, C
AU  - Li C
AD  - Clinical Genetics Program, Department of Pediatrics, McMaster University Medical 
      Center, Hamilton, Canada. lichum@mcmaster.ca
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110110
PL  - Denmark
TA  - Clin Genet
JT  - Clinical genetics
JID - 0253664
SB  - IM
MH  - Genetic Testing
MH  - Genome, Human
MH  - Genome-Wide Association Study
MH  - Humans
MH  - Pharmacogenetics/methods
MH  - Precision Medicine/*trends
EDAT- 2011/01/06 06:00
MHDA- 2011/08/04 06:00
CRDT- 2011/01/06 06:00
PHST- 2011/01/06 06:00 [entrez]
PHST- 2011/01/06 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
AID - 10.1111/j.1399-0004.2010.01609.x [doi]
PST - ppublish
SO  - Clin Genet. 2011 May;79(5):403-12. doi: 10.1111/j.1399-0004.2010.01609.x. Epub
      2011 Jan 10.


PMID- 21203821
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20220322
IS  - 1573-7225 (Electronic)
IS  - 0957-5243 (Linking)
VI  - 22
IP  - 3
DP  - 2011 Mar
TI  - Cohorts and consortia conference: a summary report (Banff, Canada, June 17-19,
      2009).
PG  - 463-8
LID - 10.1007/s10552-010-9717-0 [doi]
AB  - Epidemiologic studies have adapted to the genomics era by forming large
      international consortia to overcome issues of large data volume and small sample 
      size. Whereas both cohort and well-conducted case-control studies can inform
      disease risk from genetic susceptibility, cohort studies offer the additional
      advantages of assessing lifestyle and environmental exposure-disease time
      sequences often over a life course. Consortium involvement poses several
      logistical and ethical issues to investigators, some of which are unique to
      cohort studies, including the challenge to harmonize prospectively collected
      lifestyle and environmental exposures validly across individual studies. An open 
      forum to discuss the opportunities and challenges of large-scale cohorts and
      their consortia was held in June 2009 in Banff, Canada, and is summarized in this
      report.
FAU - Boffetta, Paolo
AU  - Boffetta P
AD  - The Tisch Cancer Institute, Mount Sinai School of Medicine, One Gustave L. Levy
      Place, New York, NY 10029, USA. paolo.boffetta@i-pri.org
FAU - Colditz, Graham A
AU  - Colditz GA
FAU - Potter, John D
AU  - Potter JD
FAU - Kolonel, Laurence
AU  - Kolonel L
FAU - Robson, Paula J
AU  - Robson PJ
FAU - Malekzadeh, Reza
AU  - Malekzadeh R
FAU - Seminara, Daniela
AU  - Seminara D
FAU - Goode, Ellen L
AU  - Goode EL
FAU - Yoo, Keun-Young
AU  - Yoo KY
FAU - Demers, Paul
AU  - Demers P
FAU - Gallagher, Richard
AU  - Gallagher R
FAU - Prentice, Ross
AU  - Prentice R
FAU - Yasui, Yutaka
AU  - Yasui Y
FAU - O'Doherty, Kieran
AU  - O'Doherty K
FAU - Petersen, Gloria M
AU  - Petersen GM
FAU - Ulrich, Cornelia M
AU  - Ulrich CM
FAU - Csizmadi, Ilona
AU  - Csizmadi I
FAU - Amankwah, Ernest K
AU  - Amankwah EK
FAU - Brockton, Nigel T
AU  - Brockton NT
FAU - Kopciuk, Karen
AU  - Kopciuk K
FAU - McGregor, S Elizabeth
AU  - McGregor SE
FAU - Kelemen, Linda E
AU  - Kelemen LE
LA  - eng
GR  - U54 CA153460/CA/NCI NIH HHS/United States
GR  - UL1 RR025741/RR/NCRR NIH HHS/United States
GR  - U54 CA155626/CA/NCI NIH HHS/United States
GR  - U54 CA155496/CA/NCI NIH HHS/United States
GR  - U01 CA114594/CA/NCI NIH HHS/United States
GR  - CAPMC/ CIHR/Canada
PT  - Comparative Study
PT  - Congress
PT  - Research Support, Non-U.S. Gov't
DEP - 20110104
PL  - Netherlands
TA  - Cancer Causes Control
JT  - Cancer causes & control : CCC
JID - 9100846
SB  - IM
MH  - Canada
MH  - *Case-Control Studies
MH  - Clinical Trials as Topic/methods
MH  - *Cohort Studies
MH  - Environmental Exposure/analysis
MH  - Humans
MH  - *Research Report
MH  - Risk Assessment/methods
MH  - Sample Size
PMC - PMC8933638
MID - NIHMS1783099
EDAT- 2011/01/05 06:00
MHDA- 2011/06/03 06:00
CRDT- 2011/01/05 06:00
PHST- 2010/08/10 00:00 [received]
PHST- 2010/12/20 00:00 [accepted]
PHST- 2011/01/05 06:00 [entrez]
PHST- 2011/01/05 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
AID - 10.1007/s10552-010-9717-0 [doi]
PST - ppublish
SO  - Cancer Causes Control. 2011 Mar;22(3):463-8. doi: 10.1007/s10552-010-9717-0. Epub
      2011 Jan 4.


PMID- 21200165
OWN - NLM
STAT- MEDLINE
DCOM- 20110413
LR  - 20220408
IS  - 1536-3724 (Electronic)
IS  - 1050-642X (Linking)
VI  - 21
IP  - 1
DP  - 2011 Jan
TI  - Is there evidence for mandating electrocardiogram as part of the
      pre-participation examination?
PG  - 13-7
LID - 10.1097/JSM.0b013e318204a7b4 [doi]
AB  - The risk of sudden cardiac death may be increased up to 2.8 times in competitive 
      athletes compared with nonathletes. The majority of sudden cardiac death cases
      are caused by an underlying abnormality that potentially may be identified on
      cardiovascular screening, depending on the specific abnormality and the content
      of the cardiovascular screening applied. Indeed, today, cardiac screening is
      universally recommended by the cardiac societies [European Society of Cardiology 
      (ESC) and American Heart Association (AHA)] and required by the sporting bodies
      [Federation Internationale de Football Association (FIFA) and Union of European
      Football Associations (UEFA)]. Pre-participation examination is by consensus
      understood to include personal history and physical examination; controversy
      exists regarding the usefulness and appropriateness of screening using resting
      12-lead electrocardiogram (ECG), with an apparent transatlantic difference. The
      ESC recommends screening consisting of personal history, physical examination,
      and 12-lead resting ECG, whereas recommendations from the AHA includes only
      personal history and physical examination. There is firm scientific ground to
      state that the sensitivity of screening with ECG is vastly superior to, and the
      cost-effectiveness significantly better than, screening without ECG. Cardiac
      screening of elite athletes with personal history, physical examination, and ECG 
      is cost-effective also in comparison with other well-accepted procedures of
      modern health care, such as dialysis and implantable cardiac defibrillators.
      Newly published recommendations for the interpretation of the ECG in athletes
      (ESC) and future studies on ECGs in athletes of different ethnicity, gender, and 
      age may further increase the specificity of ECG in cardiac screening, refining
      the screening procedure and lowering the costs for additional follow-up testing. 
      Cardiac screening without ECG is not cost-effective and may be only marginally
      better than no screening at all and at a considerable higher cost. The
      difficulties in feasibility and liability issues for recommending ECGs in some
      countries need to be acknowledged but must be dealt with within those
      countries/systems. On ethical grounds, the reasons (logistical, legal, economic) 
      for not screening individual athletes should be clearly stated. Alas, the current
      evidence, as presented here, suggests that the ECG should be mandatory in
      pre-participation screening of athletes.
FAU - Borjesson, Mats
AU  - Borjesson M
AD  - Department of Acute and Emergency Medicine, Sahlgrenska University Hospital,
      Ostra, Sahgrenska Academy, Goteborg, Sweden. mats.borjesson@vgregion.se
FAU - Dellborg, Mikael
AU  - Dellborg M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin J Sport Med
JT  - Clinical journal of sport medicine : official journal of the Canadian Academy of 
      Sport Medicine
JID - 9103300
SB  - IM
CIN - Clin J Sport Med. 2011 Sep;21(5):460; author reply 460. PMID: 21892020
MH  - *Athletes
MH  - Cardiovascular Diseases/diagnosis
MH  - Death, Sudden, Cardiac/*prevention & control
MH  - Electrocardiography/economics/*methods
MH  - *Evidence-Based Medicine
MH  - Feasibility Studies
MH  - Humans
MH  - Mandatory Testing/economics/*methods
MH  - Medical History Taking
MH  - Physical Examination/economics/*methods
MH  - Sensitivity and Specificity
MH  - Sports Medicine
EDAT- 2011/01/05 06:00
MHDA- 2011/04/14 06:00
CRDT- 2011/01/05 06:00
PHST- 2011/01/05 06:00 [entrez]
PHST- 2011/01/05 06:00 [pubmed]
PHST- 2011/04/14 06:00 [medline]
AID - 10.1097/JSM.0b013e318204a7b4 [doi]
AID - 00042752-201101000-00004 [pii]
PST - ppublish
SO  - Clin J Sport Med. 2011 Jan;21(1):13-7. doi: 10.1097/JSM.0b013e318204a7b4.


PMID- 21200038
OWN - NLM
STAT- MEDLINE
DCOM- 20110127
LR  - 20220408
IS  - 1539-3704 (Electronic)
IS  - 0003-4819 (Linking)
VI  - 154
IP  - 1
DP  - 2011 Jan 4
TI  - A systematic examination of the citation of prior research in reports of
      randomized, controlled trials.
PG  - 50-5
LID - 10.7326/0003-4819-154-1-201101040-00007 [doi]
AB  - BACKGROUND: A randomized, controlled trial (RCT) should not be started or
      interpreted without accounting for evidence from preceding RCTs addressing the
      same question. Research has suggested that evidence from prior trials is often
      not accounted for in reports of subsequent RCTs. OBJECTIVE: To assess the extent 
      to which reports of RCTs cite prior trials studying the same interventions.
      DESIGN: Meta-analyses published in 2004 that combined 4 or more trials were
      identified; within each meta-analysis, the extent to which each trial report
      cited the trials that preceded it by more than 1 year was assessed. MEASUREMENTS:
      The proportion of prior trials that were cited (prior research citation index),
      the proportion of the total participants from prior trials that were in the cited
      trials (sample size citation index), and the absolute number of trials cited were
      calculated. RESULTS: 227 meta-analyses were identified, comprising 1523 trials
      published from 1963 to 2004. The median prior research citation index was 0.21
      (95% CI, 0.18 to 0.24), meaning that less than one quarter of relevant reports
      were cited. The median sample size citation index (0.24 [CI, 0.21 to 0.27]) was
      similar, suggesting that larger trials were not selectively cited. Of the 1101
      RCTs that had 5 or more prior trials to cite, 254 (23%) cited no prior RCTs and
      257 (23%) cited only 1. The median number of prior cited trials was 2, which did 
      not change as the number of citable trials increased. The mean number of
      preceding trials cited by trials published after 2000 was 2.4, compared with 1.5 
      for those published before 2000 (P < 0.001). LIMITATION: The investigators could 
      not ascertain why prior trials were not cited, and noncited trials may have been 
      taken into account in the trial design and proposal stages. CONCLUSION: In
      reports of RCTs published over 4 decades, fewer than 25% of preceding trials were
      cited, comprising fewer than 25% of the participants enrolled in all relevant
      prior trials. A median of 2 trials was cited, regardless of the number of prior
      trials that had been conducted. Research is needed to explore the explanations
      for and consequences of this phenomenon. Potential implications include ethically
      unjustifiable trials, wasted resources, incorrect conclusions, and unnecessary
      risks for trial participants. PRIMARY FUNDING SOURCE: None.
FAU - Robinson, Karen A
AU  - Robinson KA
AD  - Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21287, USA. 
      krobin@jhmi.edu
FAU - Goodman, Steven N
AU  - Goodman SN
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Intern Med
JT  - Annals of internal medicine
JID - 0372351
SB  - IM
MH  - Humans
MH  - Meta-Analysis as Topic
MH  - Randomized Controlled Trials as Topic/methods/*standards/statistics & numerical
      data
MH  - Research Design/standards
MH  - Sample Size
EDAT- 2011/01/05 06:00
MHDA- 2011/01/29 06:00
CRDT- 2011/01/05 06:00
PHST- 2011/01/05 06:00 [entrez]
PHST- 2011/01/05 06:00 [pubmed]
PHST- 2011/01/29 06:00 [medline]
AID - 154/1/50 [pii]
AID - 10.7326/0003-4819-154-1-201101040-00007 [doi]
PST - ppublish
SO  - Ann Intern Med. 2011 Jan 4;154(1):50-5. doi:
      10.7326/0003-4819-154-1-201101040-00007.


PMID- 21199361
OWN - NLM
STAT- MEDLINE
DCOM- 20110411
LR  - 20110104
IS  - 1600-6143 (Electronic)
IS  - 1600-6135 (Linking)
VI  - 11
IP  - 1
DP  - 2011 Jan
TI  - Response: Good ethics require good science: why transplant programs should not
      disclose misattributed parentage.
PG  - 179; author reply 180-1
LID - 10.1111/j.1600-6143.2010.03307.x [doi]
FAU - Zachary, A A
AU  - Zachary AA
FAU - Leffell, M S
AU  - Leffell MS
LA  - eng
PT  - Comment
PT  - Letter
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
RN  - 0 (ABO Blood-Group System)
RN  - 0 (HLA Antigens)
SB  - IM
CON - Am J Transplant. 2010 Apr;10(4):742-6. PMID: 20132166
MH  - ABO Blood-Group System/*genetics
MH  - *Disclosure
MH  - *Ethics, Medical
MH  - Genetic Counseling
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Male
MH  - *Organ Transplantation
MH  - Paternity
MH  - Transplantation Immunology
EDAT- 2011/01/05 06:00
MHDA- 2011/04/13 06:00
CRDT- 2011/01/05 06:00
PHST- 2011/01/05 06:00 [entrez]
PHST- 2011/01/05 06:00 [pubmed]
PHST- 2011/04/13 06:00 [medline]
AID - 10.1111/j.1600-6143.2010.03307.x [doi]
PST - ppublish
SO  - Am J Transplant. 2011 Jan;11(1):179; author reply 180-1. doi:
      10.1111/j.1600-6143.2010.03307.x.


PMID- 21198684
OWN - NLM
STAT- MEDLINE
DCOM- 20110420
LR  - 20110104
IS  - 1752-0606 (Electronic)
IS  - 0194-472X (Linking)
VI  - 37
IP  - 1
DP  - 2011 Jan
TI  - Compassion fatigue in marriage and family therapy: implications for therapists
      and clients.
PG  - 1-13
LID - 10.1111/j.1752-0606.2009.00147.x [doi]
AB  - Given that marriage and family therapists are exposed to a wide range of
      circumstances that leave them uniquely vulnerable to experiencing compassion
      fatigue, it is important to examine the stresses and hazards they face and what
      those consequences mean for both themselves and clients. It is essential that
      they identify how compassion fatigue negatively affects the therapeutic
      relationship and overall treatment outcome as well as that of the personal life
      of the family therapist. The marriage and family therapist is responsible and
      ethically obligated to identify and implement ways in which he or she can prevent
      and remedy compassion fatigue.
CI  - (c) 2011 American Association for Marriage and Family Therapy.
FAU - Negash, Sesen
AU  - Negash S
AD  - Purdue University Calumet, USA. smnegash@yahoo.com
FAU - Sahin, Seda
AU  - Sahin S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Marital Fam Ther
JT  - Journal of marital and family therapy
JID - 7904614
SB  - IM
MH  - *Empathy
MH  - *Family Therapy
MH  - Fatigue/prevention & control/*psychology
MH  - Grief
MH  - Humans
MH  - *Marital Therapy
MH  - Quality Assurance, Health Care
MH  - Wounds and Injuries/psychology
EDAT- 2011/01/05 06:00
MHDA- 2011/04/22 06:00
CRDT- 2011/01/05 06:00
PHST- 2011/01/05 06:00 [entrez]
PHST- 2011/01/05 06:00 [pubmed]
PHST- 2011/04/22 06:00 [medline]
AID - 10.1111/j.1752-0606.2009.00147.x [doi]
PST - ppublish
SO  - J Marital Fam Ther. 2011 Jan;37(1):1-13. doi: 10.1111/j.1752-0606.2009.00147.x.


PMID- 21197243
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20220309
IS  - 1998-3921 (Electronic)
IS  - 1998-3921 (Linking)
VI  - 7
IP  - 1
DP  - 2011 Jan
TI  - Minimal invasive single-site surgery in colorectal procedures: Current state of
      the art.
PG  - 52-60
LID - 10.4103/0972-9941.72382 [doi]
AB  - BACKGROUND: Minimally invasive single-site (MISS) surgery has recently been
      applied to colorectal surgery. We aimed to assess the current state of the art
      and the adequacy of preliminary oncological results. METHODS: We performed a
      systematic review of the literature using Pubmed, Medline, SCOPUS and Web of
      Science databases. Keywords used were "Single Port" or "Single-Incision" or
      "LaparoEndoscopic Single Site" or "SILS" and "Colon" or "Colorectal" and
      "Surgery". RESULTS: Twenty-nine articles on colorectal MISS surgery have been
      published from July 2008 to July 2010, presenting data on 149 patients. One study
      reported analgesic requirement. The final incision length ranged from 2.5 to 8
      cm. Only two studies reported fascial incision length. There were two port site
      hernias in a series of 13 patients (15.38%). Two "fully laparoscopic" MISS
      procedures with preparation and achievement of the anastomosis completely
      intracorporeally are reported. Future site of ileostomy was used as the sole
      access for the procedures in three studies. Lymph node harvesting, resection
      margins and length of specimen were sufficient in oncological cases. CONCLUSIONS:
      MISS colorectal surgery is a challenging procedure that seems to be safe and
      feasible, but the existing clinical evidence is limited. In selected cases, and
      especially when an ileostomy is planned, colorectal surgery may be an ideal
      indication for MISS surgery leading to a no-scar surgery. Despite preliminary
      oncological results showing the feasibility of MISS surgery, we want to stress
      the need to standardize the technique and carefully evaluate its application in
      oncosurgery under ethical committee control.
FAU - Diana, Michele
AU  - Diana M
AD  - Department of Surgery, IRCAD/EITS, Hopitaux Universitaires, 1 Place de l'Hopital,
      67091, Strasbourg Cedex, France.
FAU - Dhumane, Parag
AU  - Dhumane P
FAU - Cahill, R A
AU  - Cahill RA
FAU - Mortensen, N
AU  - Mortensen N
FAU - Leroy, Joel
AU  - Leroy J
FAU - Marescaux, Jacques
AU  - Marescaux J
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Minim Access Surg
JT  - Journal of minimal access surgery
JID - 101228183
PMC - PMC3002007
OTO - NOTNLM
OT  - Colorectal surgery
OT  - laparoendoscopic single-site surgery
OT  - minimal invasive single-site surgery
OT  - single port access
OT  - single-incision laparoscopic surgery
EDAT- 2011/01/05 06:00
MHDA- 2011/01/05 06:01
CRDT- 2011/01/04 06:00
PHST- 2010/07/15 00:00 [received]
PHST- 2010/08/02 00:00 [accepted]
PHST- 2011/01/04 06:00 [entrez]
PHST- 2011/01/05 06:00 [pubmed]
PHST- 2011/01/05 06:01 [medline]
AID - 10.4103/0972-9941.72382 [doi]
PST - ppublish
SO  - J Minim Access Surg. 2011 Jan;7(1):52-60. doi: 10.4103/0972-9941.72382.


PMID- 21196498
OWN - NLM
STAT- MEDLINE
DCOM- 20110615
LR  - 20161020
IS  - 1526-3347 (Electronic)
IS  - 0191-9601 (Linking)
VI  - 32
IP  - 1
DP  - 2011 Jan
TI  - Ethics for the pediatrician: physician interaction with the pharmaceutical
      industry.
PG  - e1-3
LID - 10.1542/pir.32-1-e1 [doi]
FAU - Cicero, Mark X
AU  - Cicero MX
AD  - Yale University School of Medicine, New Haven, CT, USA.
FAU - Curi, Michael B
AU  - Curi MB
FAU - Mercurio, Mark
AU  - Mercurio M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pediatr Rev
JT  - Pediatrics in review
JID - 8103046
SB  - IM
MH  - Drug Industry/economics/*ethics
MH  - Education, Medical, Continuing/economics/ethics
MH  - Gift Giving/ethics
MH  - Humans
MH  - Interprofessional Relations/*ethics
MH  - Pediatrics/*ethics
MH  - Practice Patterns, Physicians'/ethics
EDAT- 2011/01/05 06:00
MHDA- 2011/06/16 06:00
CRDT- 2011/01/04 06:00
PHST- 2011/01/04 06:00 [entrez]
PHST- 2011/01/05 06:00 [pubmed]
PHST- 2011/06/16 06:00 [medline]
AID - 32/1/e1 [pii]
AID - 10.1542/pir.32-1-e1 [doi]
PST - ppublish
SO  - Pediatr Rev. 2011 Jan;32(1):e1-3. doi: 10.1542/pir.32-1-e1.


PMID- 21196324
OWN - NLM
STAT- MEDLINE
DCOM- 20110603
LR  - 20220224
IS  - 1945-0508 (Electronic)
IS  - 1945-0494 (Linking)
VI  - 3
IP  - 2
DP  - 2011 Jan 1
TI  - Obesity in pregnancy: problems and potential solutions.
PG  - 442-52
AB  - Recent years have witnessed an increase in the prevalence of maternal obesity
      during pregnancy in the United States and worldwide. Obese women have increased
      risks for gestational problems, such as diabetes, hypertension, and
      pre-eclampsia. Further, gestational obesity can adversely impact fetal growth and
      result in macrosomia, congenital abnormalities, and even fetal death. Measures
      must be taken to reduce maternal adiposity, as even a modest weight loss during
      pregnancy is beneficial for the health of mothers and fetus. Calorie restriction 
      and moderate exercise are proven safe methods of stopping weight gain and/or
      inducing white-fat loss in these subjects. Additionally, therapeutic drugs that
      activate the AMP-activated protein kinase signaling pathway may be effective in
      ameliorating pathological conditions in obese patients. Finally, dietary
      supplementation with L-arginine or its effective precursor (L-citrulline) may be 
      beneficial for managing overweight or obese gestating women by reducing white-fat
      accretion. Because of ethical concerns over human studies, animal models (e.g.,
      sheep, pigs, baboons, rats, and mice) are warranted to test novel hypotheses with
      enormous biological significance and clinical applications.
FAU - McKnight, Jason R
AU  - McKnight JR
AD  - Faculty of Nutrition, Department of Animal Science, Texas A&M University, College
      Station, TX 77843-2471, USA. jrm001@tamu.edu
FAU - Satterfield, M Carey
AU  - Satterfield MC
FAU - Li, Xilong
AU  - Li X
FAU - Gao, Haijun
AU  - Gao H
FAU - Wang, Junjun
AU  - Wang J
FAU - Li, Defa
AU  - Li D
FAU - Wu, Guoyao
AU  - Wu G
LA  - eng
GR  - 1R21 HD049449/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20110101
PL  - Singapore
TA  - Front Biosci (Elite Ed)
JT  - Frontiers in bioscience (Elite edition)
JID - 101485240
RN  - 0 (Amino Acids)
SB  - IM
MH  - Amino Acids
MH  - Blood Coagulation Disorders/etiology/*physiopathology
MH  - Caloric Restriction/methods
MH  - Dietary Supplements
MH  - Exercise
MH  - Female
MH  - Fetal Distress/etiology/*physiopathology
MH  - Humans
MH  - Hypertension/etiology/*physiopathology
MH  - Insulin Resistance/physiology
MH  - Obesity/*complications/drug therapy/prevention & control
MH  - Pre-Eclampsia/etiology/*physiopathology
MH  - Pregnancy
MH  - Pregnancy Complications/etiology/*physiopathology
MH  - Venous Thrombosis/etiology/*physiopathology
EDAT- 2011/01/05 06:00
MHDA- 2011/06/04 06:00
CRDT- 2011/01/04 06:00
PHST- 2011/01/04 06:00 [entrez]
PHST- 2011/01/05 06:00 [pubmed]
PHST- 2011/06/04 06:00 [medline]
AID - 259 [pii]
AID - 10.2741/e259 [doi]
PST - epublish
SO  - Front Biosci (Elite Ed). 2011 Jan 1;3(2):442-52. doi: 10.2741/e259.


PMID- 21194646
OWN - NLM
STAT- MEDLINE
DCOM- 20110505
LR  - 20220317
IS  - 1873-2496 (Electronic)
IS  - 1078-1439 (Linking)
VI  - 29
IP  - 1
DP  - 2011 Jan-Feb
TI  - International perspectives on plagiarism and considerations for teaching
      international trainees.
PG  - 104-8
LID - 10.1016/j.urolonc.2010.09.014 [doi]
AB  - In the increasingly global community of biomedical science and graduate science
      education, many US academic researchers work with international trainees whose
      views on scientific writing and plagiarism can be strikingly different from US
      norms. Although a growing number of countries and international professional
      organizations identify plagiarism as research misconduct, many international
      trainees come from research environments where plagiarism is ill-defined and even
      commonly practiced. Two research-ethics educators consider current perspectives
      on plagiarism around the world and contend that US research-training programs
      should focus on trainees' scientific writing skills and acculturation, not simply
      on preventing plagiarism.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Heitman, Elizabeth
AU  - Heitman E
AD  - Center for Biomedical Ethics and Society, Vanderbilt University Medical Center,
      Nashville, TN 37203, USA. elizabeth.heitman@vanderbilt.edu
FAU - Litewka, Sergio
AU  - Litewka S
LA  - eng
GR  - R25 TW007697/TW/FIC NIH HHS/United States
GR  - R25 TW007697-04/TW/FIC NIH HHS/United States
GR  - R25 TW008186/TW/FIC NIH HHS/United States
GR  - R25 TW008186-04/TW/FIC NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
PL  - United States
TA  - Urol Oncol
JT  - Urologic oncology
JID - 9805460
SB  - IM
MH  - Biomedical Research/*education
MH  - Ethics, Research/*education
MH  - Humans
MH  - Internationality
MH  - *Plagiarism
MH  - Scientific Misconduct/*ethics
MH  - Writing
PMC - PMC3038591
MID - NIHMS256497
EDAT- 2011/01/05 06:00
MHDA- 2011/05/06 06:00
CRDT- 2011/01/04 06:00
PHST- 2010/09/10 00:00 [received]
PHST- 2010/09/28 00:00 [accepted]
PHST- 2011/01/04 06:00 [entrez]
PHST- 2011/01/05 06:00 [pubmed]
PHST- 2011/05/06 06:00 [medline]
AID - S1078-1439(10)00271-1 [pii]
AID - 10.1016/j.urolonc.2010.09.014 [doi]
PST - ppublish
SO  - Urol Oncol. 2011 Jan-Feb;29(1):104-8. doi: 10.1016/j.urolonc.2010.09.014.


PMID- 21193772
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20190709
IS  - 1943-4723 (Electronic)
IS  - 0002-8177 (Linking)
VI  - 142
IP  - 1
DP  - 2011 Jan
TI  - Are there ethical considerations to keep in mind as a dentist approaches
      retirement?
PG  - 93-4
FAU - Waugh, W Scott
AU  - Waugh WS
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Am Dent Assoc
JT  - Journal of the American Dental Association (1939)
JID - 7503060
SB  - IM
MH  - Clinical Competence
MH  - Dental Care/standards
MH  - Dentist-Patient Relations/ethics
MH  - Dentists/*ethics
MH  - *Ethics, Dental
MH  - Humans
MH  - Partnership Practice, Dental/ethics
MH  - Practice Management, Dental/ethics
MH  - Retirement/*ethics
EDAT- 2011/01/05 06:00
MHDA- 2011/06/03 06:00
CRDT- 2011/01/04 06:00
PHST- 2011/01/04 06:00 [entrez]
PHST- 2011/01/05 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
AID - S0002-8177(14)61880-8 [pii]
AID - 10.14219/jada.archive.2011.0035 [doi]
PST - ppublish
SO  - J Am Dent Assoc. 2011 Jan;142(1):93-4. doi: 10.14219/jada.archive.2011.0035.


PMID- 33829217
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210410
VI  - 1
IP  - 3
DP  - 2011 Jan
TI  - A Practical Framework for Navigating Ethical Challenges in Collaborative
      Community Research.
PG  - 12-22
LID - 10.7728/0103201102 [doi]
AB  - To effectively mobilize community-based organizations (CBOs) and international
      non-governmental organizations (NGOs) in research, important ethical issues must 
      be addressed. A memorandum of understanding (MOU), providing a framework and a
      tool to be used for establishing effective community-research partnerships, was
      developed by the Community Collaboration Core (CCC) of the HIV Center for
      Clinical and Behavioral Studies. Aims of the CCC include: (1) Initiating and
      sustaining successful partnerships in HIV prevention research in areas of
      sexuality, gender, mental health, and of mutual benefit to communities; (2)
      Advancing the science of collaboration among researchers, practitioners, and
      government in HIV prevention. Developed and assessed over a two-year period by
      researchers, CBO/NGO and public health representatives, this MOU can be used by
      potential research and community partners to address the most important issues
      early in a collaborative research project. Clarifying essential roles,
      responsibilities, and relationships, establishing trust and transparency in that 
      process, can guide collaborators in planning the important steps for beginning
      and sustaining an ethical and successful research project.
FAU - Hunter, Joyce
AU  - Hunter J
AD  - HIV Center for Clinical and Behavioral Studies, New York State Psychiatric
      Institute and Columbia University, 1051 Riverside Drive, Unit 15, New York, NY
      10032, ; ; JHuntLGhlt@aol.com.
FAU - Lounsbury, David
AU  - Lounsbury D
AD  - Department of Epidemiology and Population Health, Division of Community
      Collaboration and Dissemination Science, Albert Einstein College of Medicine,
      1300 Morris Park Avenue, Belfer Building 13 Floor, Bronx, NY 10461,.
FAU - Rapkin, Bruce
AU  - Rapkin B
AD  - Department of Epidemiology and Population Health, Director, Division of Community
      Collaboration and Dissemination Science, Albert Einstein College of Medicine,
      1300 Morris Park Avenue, Belfer Building 13 Floor, Bronx, NY 10461,.
FAU - Remien, Robert
AU  - Remien R
AD  - HIV Center for Clinical and Behavioral Studies, New York State Psychiatric
      Institute and Columbia University, 1051 Riverside Drive, Unit 15, New York, NY
      10032,.
LA  - eng
GR  - P30 MH043520/MH/NIMH NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Glob J Community Psychol Pract
JT  - Global journal of community psychology practice
JID - 101535804
PMC - PMC8023300
MID - NIHMS245312
OTO - NOTNLM
OT  - Research ethics
OT  - academic-community partnerships
OT  - collaboration
OT  - community-based participatory research methods
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2021/04/08 06:34
PHST- 2021/04/08 06:34 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - 10.7728/0103201102 [doi]
PST - ppublish
SO  - Glob J Community Psychol Pract. 2011 Jan;1(3):12-22. doi: 10.7728/0103201102.


PMID- 32215190
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1951-6355 (Print)
IS  - 1951-6355 (Linking)
VI  - 195
IP  - 1
DP  - 2011
TI  - From social data mining to forecasting socio-economic crises.
PG  - 3
LID - 10.1140/epjst/e2011-01401-8 [doi]
AB  - The purpose of this White Paper of the EU Support Action "Visioneer"(see
      www.visioneer.ethz.ch) is to address the following goals: Develop strategies to
      quickly increase the objective knowledge about social and economic
      systems.Describe requirements for efficient large-scale scientific data mining of
      anonymized social and economic data.Formulate strategies how to collect stylized 
      facts extracted from large data set.Sketch ways how to successfully build up
      centers for computational social science.Propose plans how to create centers for 
      risk analysis and crisis forecasting.Elaborate ethical standards regarding the
      storage, processing, evaluation, and publication of social and economic data.
CI  - (c) EDP Sciences and Springer 2011.
FAU - Helbing, D
AU  - Helbing D
AD  - 1ETH Zurich, CLU, Clausiusstr. 50, 8092 Zurich,
      Switzerland.grid.5801.c0000000121562780
AD  - 2Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, NM 87501
      USA.grid.209665.e0000000119411940
FAU - Balietti, S
AU  - Balietti S
AD  - 1ETH Zurich, CLU, Clausiusstr. 50, 8092 Zurich,
      Switzerland.grid.5801.c0000000121562780
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110530
PL  - France
TA  - Eur Phys J Spec Top
JT  - The European physical journal. Special topics
JID - 101516555
PMC - PMC7088654
OTO - NOTNLM
OT  - Computational Social Science
OT  - Electronic Frontier Foundation
OT  - European Physical Journal Special Topic
OT  - Reality Mining
OT  - Recommender System
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2020/03/28 06:00
PHST- 2010/10/16 00:00 [received]
PHST- 2011/03/21 00:00 [revised]
PHST- 2020/03/28 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - 10.1140/epjst/e2011-01401-8 [doi]
AID - 1401 [pii]
PST - ppublish
SO  - Eur Phys J Spec Top. 2011;195(1):3. doi: 10.1140/epjst/e2011-01401-8. Epub 2011
      May 30.


PMID- 29296308
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220311
IS  - 2156-4639 (Print)
VI  - 1
IP  - 2
DP  - 2011
TI  - Radiation Associated Meningiomas:The Case for Repeat Radiotherapy.
PG  - 141-145
AB  - PURPOSE: To evaluate the circumstances relating to Radiation Associated
      Meningiomas (RAM) and whether repeat radiotherapy can be used. MATERIALS AND
      METHODS: In this Ethics Approved Study, databases of the Long Term Follow-Up
      Clinic at Sydney Children's Hospital and the Prince of Wales Cancer Centre were
      audited for patients who received radiotherapy to the head as a child, and
      subsequently developed an intracranial meningioma. Features noted were, initial
      diagnosis, extent of prior treatment, dose, latency to diagnosis, subsequent
      treatment, and outcome. RESULTS: There were 18 patients with an equal gender mix 
      of males/females (9), the majority of patients being treated with whole brain
      radiotherapy for leukaemia prophylaxis. 6 patients had radiotherapy, 4 had
      follow-up out to 17 years with no further adverse event, and control of the
      meningioma. CONCLUSION: Surgery may still be the treatment of choice, however
      where appropriate radiotherapy can be considered, with good prospect of benefit
      to the patient.
FAU - Smee, Robert I
AU  - Smee RI
AD  - Department of Radiation Oncology, The Prince of Wales Cancer Centre, High St,
      Randwick, New South Wales, Australia.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Radiosurg SBRT
JT  - Journal of radiosurgery and SBRT
JID - 101565296
PMC - PMC5675471
OTO - NOTNLM
OT  - Paediatric tumours
OT  - SRS/SIMRT
OT  - latency period
OT  - radiation-associated meningiomas
OT  - radiotherapy
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2018/01/04 06:00
PHST- 2018/01/04 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
PST - ppublish
SO  - J Radiosurg SBRT. 2011;1(2):141-145.


PMID- 27820581
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1838-2142 (Print)
IS  - 1838-2142 (Linking)
VI  - 9
IP  - 42
DP  - 2011
TI  - Patients' experiences towards the donation of their residual biological samples
      and the impact of these experiences on the type of consent given for secondary
      use: A systematic review.
PG  - 1714-1781
AB  - EXECUTIVE SUMMARY: Background Residual or leftover clinical tissues are valuable 
      resources for biomedical research. There is on-going discussion about the
      methodological, legal, and ethical issues on the collection, storage and use of
      these tissues for future research. This systematic review will consider
      qualitative studies previously conducted, which report on patients' preferences, 
      experiences and willingness to donate their tissues.Objectives The aim of this
      review was to critically appraise, synthesize and present the best available
      evidence related to the experiences of patients toward consent when donating
      their leftover tissue for research.Search strategy The search strategy aimed to
      find both published and unpublished studies. A three-step search strategy was
      utilized. An initial limited search of MEDLINE and CINAHL was undertaken,
      followed by analysis of text words contained in the title and abstract, and of
      the index terms used to describe the article. A second search using all
      identified keywords and index terms was then undertaken across all included
      databases. Thirdly, the reference lists of all identified reports and articles
      were searched for additional studies.Data collection & analysis The standardised 
      data extraction tool from the Joanna Briggs Institute Qualitative Assessment and 
      Review Instrument (JBI-QARI) was used to extract data from each paper. The
      qualitative research findings were presented as thematic pooling using the
      JBI-QARI approach in a narrative form. During the analysis, 131 study findings
      from 18 publications were aggregated into 19 categories to form four synthesized 
      findings.Main results The synthesized findings generated were: (1) Healthcare
      professionals should be aware that patients' consent to the use of their
      left-over tissues are influenced by many and varied factors. Primarily these
      factors included: benefits to self and other and trust in research and
      researchers; (2) Healthcare institutions and regulatory authorities must provide 
      strict safeguards and controls in order to maintain privacy and confidentiality
      of the patients; (3) Healthcare professionals should be aware that the views on
      ownership and rights to the tissues will vary between individual patients; (4)
      Healthcare professionals, institutions and regulatory authorities should be aware
      that patients have different views on the commercial use of their
      tissues.Discussion Patients would prefer that institutions requesting donation of
      leftover tissues establish a good governance system for the collection and
      storage of tissues, as well as a system for protecting the rights and
      confidentiality of patients. Most patients prefer to have an ethical and
      effective system, which decides the future use of their tissues, especially when 
      a full informed consent is not obtained from the patients at time of donation and
      subsequent use.Implications for Practice The results from this review can assist 
      researchers and policy makers to understand the experiences of patients and their
      attitudes and preferences on the collection, storage, distribution and use of
      their leftover tissue for research. This is especially so when designing a
      prospective model of consent regimen, to respect patients' needs and make
      recommendations for the use of existing and previously collected biological
      samples with no consent taken.Implications for Research Further qualitative
      research can be undertaken to ascertain patients' expectations when they donate
      their tissues; the type of consent model to be used; the perceived risks of
      genetic and stem cells research; and the effects of culture, religion and age on 
      patients' willingness to donate their leftover tissues for future research.
FAU - Wai, Chan Tuck
AU  - Wai CT
AD  - 1. Chan Tuck Wai. B.Sc. (Pharmacy), MBA. Yong Loo Lin School of Medicine.
      National University of Singapore 2. Dr Sandra Jane Mackey. RN, BN (Hons), PhD.
      Alice Lee Centre for Nursing Studies. Yong Loo Lin School of Medicine. National
      University of Singapore 3. Professor Desley Gail Hegney. RN, BA (Hons), DNE, PhD.
      School of Population Health, The University of Western Australia and Centre for
      Nursing Research, Sir Charles Gairdner Hospital, Perth, Western Australia.
FAU - Mackey, Sandra Jane
AU  - Mackey SJ
FAU - Hegney, Desley Gail
AU  - Hegney DG
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - JBI Libr Syst Rev
JT  - JBI library of systematic reviews
JID - 101688957
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2016/11/08 06:00
PHST- 2016/11/08 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - 01938924-201109420-00001 [pii]
AID - 10.11124/01938924-201109420-00001 [doi]
PST - ppublish
SO  - JBI Libr Syst Rev. 2011;9(42):1714-1781. doi: 10.11124/01938924-201109420-00001.


PMID- 27656721
OWN - HMD
STAT- PubMed-not-MEDLINE
DCOM- 20161025
LR  - 20191113
IS  - 0952-6951 (Print)
IS  - 0952-6951 (Linking)
VI  - 24
IP  - 5
DP  - 2011
TI  - Eurocentrism beyond the 'universalism vs. particularism' dilemma: Habermas and
      Derrida's joint plea for a new Europe.
PG  - 142-66
AB  - [[cosmopolitanismexpansionismidealismparticularismUNuniversalism ]] Is it
      Eurocentric on the part of western philosophers (Habermas, Derrida) or of
      researchers in human sciences to set out from a specific locality (Europe) to
      formulate ethico-political ideals with universal aspirations? In this article, I 
      critique the 'universalism vs. particularism' framework within which the charge
      of Eurocentrism is deployed and I redefine the notion of Eurocentrism outside the
      drastic choice between universalism and particularism and in light of an
      'ec-centric' reflection on the entanglement of the 'We' and the 'others'. I
      illustrate my position by discussing the Habermasian-Derridean plea for the
      determination of new European political responsibilities beyond any Eurocentrism.
      I grant that the two philosophers go indeed beyond Eurocentrism as the latter is 
      usually understood, i.e. along the axis 'universal-particular'. Yet, without
      minimizing their political contribution, I detect subtler Eurocentrisms that
      pervade several assumptions of Habermas's and Derrida's collaborative efforts. I 
      argue that a hasty enlisting of possibilities for a politically and morally
      pertinent European intervention in world affairs fails to account for other, more
      necessary steps in the direction of reforming the western consciousness and of
      going beyond less easily discernible Eurocentrisms such as those theorized within
      the proposed, reformulated notion.
FAU - Papastephanou, Marianna
AU  - Papastephanou M
AD  - University of Cyprus, Cyprus.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Hist Human Sci
JT  - History of the human sciences
JID - 100967737
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2016/09/23 06:00
PHST- 2016/09/23 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - 10.1177/0952695111422317 [doi]
PST - ppublish
SO  - Hist Human Sci. 2011;24(5):142-66. doi: 10.1177/0952695111422317.


PMID- 27616857
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160912
LR  - 20200929
IS  - 0974-7052 (Print)
IS  - 0974-7052 (Linking)
VI  - 4
IP  - 1
DP  - 2011 Jan-Apr
TI  - ABCD of Safe Dental Practice.
PG  - 41-2
LID - 10.5005/jp-journals-10005-1079 [doi]
AB  - Dental practice is the integral component of the oral health. Though the dental
      practice is in close relation with that of the medical practice, it has its own
      distinctiveness in relation to safe practice. The safe dental practice should not
      only assure good oral and general health but also improve social interaction by
      enhancing physical appearance, esthetics, etc. For the safe dental practice,
      dentists must excel in patient care and standard of treatment. The interlocking
      missions of education, research, and patient care are the cornerstones for the
      safe and healthy dental practice. This paper is designed to bridge the gap
      between the educational preparation of the dentist and the reality of the working
      world in a simple way.
FAU - Babu, K Sunil
AU  - Babu KS
AD  - Senior Lecturer, Department of Pedodontics and Preventive Dentistry, Mamata
      Dental College Khammam, Andhra Pradesh, India.
FAU - Reddy B, V Thimma
AU  - Reddy B VT
AD  - Professor and Head, Department of Pedodontics and Preventive Dentistry, Mamata
      Dental College Khammam, Andhra Pradesh, India.
FAU - Reddy, C Pujita
AU  - Reddy CP
AD  - Senior Lecturer, Department of Pedodontics and Preventive Dentistry, Mamata
      Dental College Khammam, Andhra Pradesh, India.
FAU - Lalita, Sree
AU  - Lalita S
AD  - Senior Lecturer, Department of Oral and Maxillofacial Surgery, MNR Dental
      College, Sangareddy, Andhra Pradesh, India.
LA  - eng
PT  - Journal Article
DEP - 20110415
PL  - India
TA  - Int J Clin Pediatr Dent
JT  - International journal of clinical pediatric dentistry
JID - 101585405
PMC - PMC4999636
OTO - NOTNLM
OT  - Ethical practice.
OT  - Practice management
OT  - Professionalizm
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2016/09/13 06:00
PHST- 2010/07/25 00:00 [received]
PHST- 2010/08/17 00:00 [accepted]
PHST- 2016/09/13 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - 10.5005/jp-journals-10005-1079 [doi]
PST - ppublish
SO  - Int J Clin Pediatr Dent. 2011 Jan-Apr;4(1):41-2. doi:
      10.5005/jp-journals-10005-1079. Epub 2011 Apr 15.


PMID- 26998398
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160321
LR  - 20201001
IS  - 2155-1790 (Print)
IS  - 2155-1790 (Linking)
VI  - 2
IP  - 1
DP  - 2011
TI  - Prospects for Induced Phiripotent Stem Cell-Derived Hepatocytes in Cell Therapy.
PG  - 1-8
LID - 10.3727/215517911X575975 [doi]
AB  - Induced pluripotent stem (iPS) cells, first established in 2006, have the same
      characteristics of self-renew-ability and pluripotency as embryonic stem (ES)
      cells. iPS cells are inducible from patient-specific somatic cells; therefore,
      they hold significant advantages for overcoming immunological rejection as well
      as the ethical issues associated with the derivation of ES cells from embryos.
      Generation of patient-derived hepatocytes by iPS technology and their use in cell
      transplantation therapy for patients with liver disease is quite attractive.
      Here, we discuss recent advances and challenges in hepatocyte differentiation
      from iPS cells and their utility in cell therapy.
FAU - Iwamuro, Masaya
AU  - Iwamuro M
AD  - Department of Gastroenterology and Hepatology, Okayama University Graduate School
      of Medicine, Dentistry, and Pharmaceutical Sciences , Okayama , Japan.
FAU - Shahid, Javed M
AU  - Shahid JM
AD  - dagger Department of Gastroenterological Surgery, Transplant and Surgical
      Oncology, Okayama University Graduate School of Medicine, Dentistry, and
      Pharmaceutical Sciences , Okayama , Japan.
FAU - Yamamoto, Kazuhide
AU  - Yamamoto K
AD  - Department of Gastroenterology and Hepatology, Okayama University Graduate School
      of Medicine, Dentistry, and Pharmaceutical Sciences , Okayama , Japan.
FAU - Kobayashif, Naoya
AU  - Kobayashif N
AD  - dagger Department of Gastroenterological Surgery, Transplant and Surgical
      Oncology, Okayama University Graduate School of Medicine, Dentistry, and
      Pharmaceutical Sciences , Okayama , Japan.
LA  - eng
PT  - Journal Article
DEP - 20110429
PL  - United States
TA  - Cell Med
JT  - Cell medicine
JID - 101544564
PMC - PMC4789313
OTO - NOTNLM
OT  - Hepatic differentiation
OT  - Hepatocytes
OT  - Induced pluripotent stem (iPS) cells
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2016/03/22 06:00
PHST- 2016/03/22 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - 10.3727/215517911X575975 [doi]
AID - CM-2-01 [pii]
PST - epublish
SO  - Cell Med. 2011 Apr 29;2(1):1-8. doi: 10.3727/215517911X575975. eCollection 2011.


PMID- 26486222
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151021
LR  - 20200928
IS  - 2076-2615 (Print)
IS  - 2076-2615 (Linking)
VI  - 1
IP  - 1
DP  - 2011 Feb 15
TI  - A Conservation Ethic and the Collecting of Animals by Institutions of Natural
      Heritage in the Twenty-First Century: Case Study of the Australian Museum.
PG  - 176-85
LID - 10.3390/ani1010176 [doi]
AB  - Collecting of animals from their habitats for preservation by museums and related
      bodies is a core operation of such institutions. Conservation of biodiversity in 
      the current era is a priority in the scientific agendas of museums of natural
      heritage in Australia and the world. Intuitively, to take animals from the wild, 
      while engaged in scientific or other practices that are supposed to promote their
      ongoing survival, may appear be incompatible. The Australian Museum presents an
      interesting ground to consider zoological collecting by museums in the
      twenty-first century. Anderson and Reeves in 1994 argued that a milieu existed
      that undervalued native species, and that the role of natural history museums, up
      to as late as the mid-twentieth century, was only to make a record the faunal
      diversity of Australia, which would inevitably be extinct. Despite the latter,
      conservation of Australia's faunal diversity is a key aspect of research
      programmes in Australia's institutions of natural heritage in the current era.
      This paper analyses collecting of animals, a core task for institutions of
      natural heritage, and how this interacts with a professed "conservation ethic" in
      a twenty-first century Australian setting.
FAU - Ikin, Timothy
AU  - Ikin T
AD  - Department of Museum Studies, School of Letters, Arts and Media, Faculty of Arts,
      University of Sydney, Sydney, NSW 2006, Australia. tiki3446@uni.sydney.edu.au.
LA  - eng
PT  - Journal Article
DEP - 20110215
PL  - Switzerland
TA  - Animals (Basel)
JT  - Animals : an open access journal from MDPI
JID - 101635614
PMC - PMC4552205
OTO - NOTNLM
OT  - Australian museum
OT  - animal conservation
OT  - biological collections
OT  - collecting
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2015/10/22 06:00
PHST- 2011/01/18 00:00 [received]
PHST- 2011/01/27 00:00 [accepted]
PHST- 2015/10/22 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - ani1010176 [pii]
AID - 10.3390/ani1010176 [doi]
PST - epublish
SO  - Animals (Basel). 2011 Feb 15;1(1):176-85. doi: 10.3390/ani1010176.


PMID- 26486221
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151021
LR  - 20200930
IS  - 2076-2615 (Print)
IS  - 2076-2615 (Linking)
VI  - 1
IP  - 1
DP  - 2011 Jan 27
TI  - Countering Brutality to Wildlife, Relationism and Ethics: Conservation, Welfare
      and the 'Ecoversity'.
PG  - 161-75
LID - 10.3390/ani1010161 [doi]
AB  - Wildlife objectification and cruelty are everyday aspects of Australian society
      that eschew values of human kindness, empathy, and an understanding of the
      uniqueness and importance of non-human life in the natural world. Fostered by
      institutional failure, greed and selfishness, and the worst aspects of human
      disregard, the objectification of animals has its roots in longstanding Western
      anthropocentric philosophical perspectives, post colonialism, and a global uptake
      of neoliberal capitalism. Conservation, animal rights and welfare movements have 
      been unable to stem the ever-growing abuse of wildlife, while 'greenwash'
      language such as 'resource use', 'management', 'pests', 'over-abundance',
      'conservation hunting' and 'ecology' coat this violence with a respectable public
      veneer. We propose an engaged learning approach to address the burgeoning culture
      of wildlife cruelty and objectification that comprises three elements: a
      relational ethic based on intrinsic understanding of the way wildlife and humans 
      might view each other [1-3]; geography of place and space [4], where there are
      implications for how we ascribe contextual meaning and practice in human-animal
      relations; and, following [5], engaged learning designed around our ethical
      relations with others, beyond the biophysical and novel and towards the
      reflective metaphysical. We propose the 'ecoversity' [6], as a scholarly and
      practical tool for focusing on the intersection of these three elements as an
      ethical place-based learning approach to wildlife relationism. We believe it
      provides a mechanism to help bridge the gap between human and non-human animals, 
      conservation and welfare, science and understanding, and between objectification 
      and relationism as a means of addressing entrenched cruelty to wildlife.
FAU - Garlick, Steve
AU  - Garlick S
AD  - Centre for Urban and Regional Studies, University of Newcastle, New South Wales, 
      Australia. sgarlick@msn.com.au.
AD  - Sustainability Research Centre, University of the Sunshine Coast, Queensland,
      Australia. sgarlick@msn.com.au.
FAU - Matthews, Julie
AU  - Matthews J
AD  - Sustainability Research Centre, University of the Sunshine Coast, Queensland,
      Australia. jmatthew@usc.edu.au.
FAU - Carter, Jennifer
AU  - Carter J
AD  - School of Social Sciences, University of the Sunshine Coast, Queensland,
      Australia. jcarter@usc.edu.au.
LA  - eng
PT  - Journal Article
DEP - 20110127
PL  - Switzerland
TA  - Animals (Basel)
JT  - Animals : an open access journal from MDPI
JID - 101635614
PMC - PMC4552203
OTO - NOTNLM
OT  - Derrida
OT  - ecoversity
OT  - ethics
OT  - universities
OT  - wildlife
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2015/10/22 06:00
PHST- 2011/01/04 00:00 [received]
PHST- 2011/01/13 00:00 [accepted]
PHST- 2015/10/22 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - ani1010161 [pii]
AID - 10.3390/ani1010161 [doi]
PST - epublish
SO  - Animals (Basel). 2011 Jan 27;1(1):161-75. doi: 10.3390/ani1010161.


PMID- 26486219
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151021
LR  - 20201001
IS  - 2076-2615 (Print)
IS  - 2076-2615 (Linking)
VI  - 1
IP  - 1
DP  - 2011 Jan 25
TI  - Integrating Values and Ethics into Wildlife Policy and Management-Lessons from
      North America.
PG  - 126-43
LID - 10.3390/ani1010126 [doi]
AB  - Few animals provoke as wide a range of emotions as wolves. Some see wolves as
      icons of a lost wilderness; others see them as intruders. As the battle continues
      between wolf proponents and opponents, finding solutions that resolve conflicts
      while supporting the integrity of nature is challenging. In this essay we argue
      that we need to make room for wolves and other native carnivores who are
      re-colonizing areas from which they were extirpated. Strategies that foster
      coexistence are necessary and wildlife agencies must consider all stakeholders
      and invest adequate resources to inform the public about how to mitigate
      conflicts between people/domestic animals, and predators. Values and ethics must 
      be woven into wildlife policy and management and we must be willing to ask
      difficult ethical questions and learn from past mistakes.
FAU - Fox, Camilla H
AU  - Fox CH
AD  - Project Coyote, Larkspur, CA 94977, USA. cfox@projectcoyote.org.
AD  - Animal Welfare Institute, Washington, DC 20003, USA. cfox@projectcoyote.org.
FAU - Bekoff, Marc
AU  - Bekoff M
AD  - Ecology and Evolutionary Biology, University of Colorado, Boulder, CO 80309-0334,
      USA. marc.bekoff@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20110125
PL  - Switzerland
TA  - Animals (Basel)
JT  - Animals : an open access journal from MDPI
JID - 101635614
PMC - PMC4552204
OTO - NOTNLM
OT  - carnivores
OT  - coexistence, attitudes
OT  - ethics
OT  - human-wildlife interaction
OT  - predator management
OT  - reintroduction
OT  - values
OT  - wildlife management
OT  - wolves
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2015/10/22 06:00
PHST- 2011/01/18 00:00 [received]
PHST- 2011/01/18 00:00 [accepted]
PHST- 2015/10/22 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - ani1010126 [pii]
AID - 10.3390/ani1010126 [doi]
PST - epublish
SO  - Animals (Basel). 2011 Jan 25;1(1):126-43. doi: 10.3390/ani1010126.


PMID- 26486217
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151021
LR  - 20201001
IS  - 2076-2615 (Print)
IS  - 2076-2615 (Linking)
VI  - 1
IP  - 1
DP  - 2011 Jan 19
TI  - Animal Rights as a Mainstream Phenomenon.
PG  - 102-15
LID - 10.3390/ani1010102 [doi]
AB  - Businesses and professions must stay in accord with social ethics, or risk losing
      their autonomy.A major social ethical issue that has emerged in the past four
      decades is the treatment of animals in various areas of human use. Society's
      moral concern has outgrown the traditional ethic of animal cruelty that began in 
      biblical times and is encoded in the laws of all civilized societies. There are
      five major reasons for this new social concern, most importantly, the replacement
      of husbandry-based agriculture with industrial agriculture. This loss of
      husbandry to industry has threatened the traditional fair contract between humans
      and animals, and resulted in significant amounts of animal suffering arising on
      four different fronts. Because such suffering is not occasioned by cruelty, a new
      ethic for animals was required to express social concerns. Since ethics proceed
      from preexisting ethics rather than ex nihilo, society has looked to its ethic
      for humans, appropriately modified, to find moral categories applicable to
      animals. This concept of legally encoded rights for animals has emerged as a
      plausible vehicle for reform.
FAU - Rollin, Bernard E
AU  - Rollin BE
AD  - Department of Philosophy, Colorado State University, Fort Collins, CO 80523, USA.
      bernard.rollin@colostate.edu.
LA  - eng
PT  - Journal Article
DEP - 20110119
PL  - Switzerland
TA  - Animals (Basel)
JT  - Animals : an open access journal from MDPI
JID - 101635614
PMC - PMC4552208
OTO - NOTNLM
OT  - animal husbandry
OT  - animal rights
OT  - anti-cruelty ethic
OT  - recollection
OT  - social ethic
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2015/10/22 06:00
PHST- 2010/12/21 00:00 [received]
PHST- 2011/01/04 00:00 [accepted]
PHST- 2015/10/22 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - ani1010102 [pii]
AID - 10.3390/ani1010102 [doi]
PST - epublish
SO  - Animals (Basel). 2011 Jan 19;1(1):102-15. doi: 10.3390/ani1010102.


PMID- 26229726
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220311
IS  - 2150-7740 (Print)
IS  - 2150-7759 (Linking)
VI  - 2
IP  - 1
DP  - 2011
TI  - Ethical Issues in Deep Brain Stimulation Research for Treatment-Resistant
      Depression: Focus on Risk and Consent.
PG  - 29-36
AB  - Deep brain stimulation (DBS) is currently in pivotal trials as an intervention
      for treatment-resistant depression (TRD). Although offering hope for TRD, DBS
      also provokes ethical concerns-particularly about decision-making capacity of
      people with depression-among bioethicists, investigators, institutional review
      boards, and the public. Here, we examine this critical issue of informed consent 
      for DBS research using available evidence regarding decision-making capacity and 
      depression. Further, we explore the implications of the nature of TRD as well as 
      that of the intervention (invasive brain surgery) for informed consent. Based on 
      these analyses, we argue that additional safeguards specific to DBS research for 
      TRD, beyond those that might be used in any higher risk study, are not supported 
      by available empirical evidence. We nevertheless underscore the limited data on
      such invasive procedures in severely ill psychiatric patients and advocate a
      research agenda for the systematic study of ethical issues raised by these
      research endeavors.
FAU - Dunn, Laura B
AU  - Dunn LB
AD  - University of California, San Francisco.
FAU - Holtzheimer, Paul E
AU  - Holtzheimer PE
AD  - Emory University.
FAU - Hoop, Jinger G
AU  - Hoop JG
AD  - Edward Hines, Jr. VA Hospital.
FAU - Mayberg, Helen S
AU  - Mayberg HS
AD  - Emory University Laura Weiss Roberts, Stanford University.
FAU - Appelbaum, Paul S
AU  - Appelbaum PS
AD  - Columbia University.
LA  - eng
GR  - K23 MH077869/MH/NIMH NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - AJOB Neurosci
JT  - AJOB neuroscience
JID - 101518076
PMC - PMC4517472
MID - NIHMS682442
OTO - NOTNLM
OT  - decision-making capacity
OT  - deep brain stimulation
OT  - depression
OT  - informed consent
OT  - neuroethics
OT  - psychiatry
OT  - research ethics
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2015/08/01 06:00
PHST- 2015/08/01 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - 10.1080/21507740.2010.533638 [doi]
PST - ppublish
SO  - AJOB Neurosci. 2011;2(1):29-36. doi: 10.1080/21507740.2010.533638.


PMID- 26068990
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150616
LR  - 20150613
IS  - 2161-2617 (Print)
IS  - 2161-2617 (Linking)
VI  - 1
IP  - 1
DP  - 2011 Mar 1
TI  - Ethical Considerations in Mouse Experiments.
PG  - 155-67
LID - 10.1002/9780470942390.mo100161 [doi]
AB  - Mice count morally because they can be harmed. This raises a moral issue in
      animal experimentation. Three main ethical attitudes towards animals are reviewed
      here. The Kantian view denies moral value to animals because they lack reason.
      The second view, by Singer, considers animals as sentient creatures (i.e., able
      to suffer). Finally, Regan considers that animals are subjects of their own life;
      they are autonomous and therefore have moral rights. Singer is a reformist and
      allows animal experimentation under certain conditions. Regan is abolitionist,
      saying that animals have moral rights that cannot be negotiated. Current animal
      protection legislation strives to put in balance the human and animal interests
      to decide whether an animal experiment is morally justified or not. An ethical
      evaluation process is conducted based on the harm-benefit assessment of the
      experiment. The researcher has to implement the 3Rs (Replacement, Reduction,
      Refinement) to minimize the harms to the animals and make sure that the outcomes 
      are scientifically significant and that the quality of the science is high, in
      order to maximize benefits to humans and animals. Curr. Protoc. Mouse Biol.
      1:155-167. (c) 2011 by John Wiley & Sons, Inc.
CI  - Copyright (c) 2011 John Wiley & Sons, Inc.
FAU - Baertschi, Bernard
AU  - Baertschi B
AD  - Institute for Biomedical Ethics, University of Geneva, Geneva, Switzerland.
FAU - Gyger, Marcel
AU  - Gyger M
AD  - EPFL-Center of Phenogenomics, Lausanne, Switzerland.
LA  - eng
PT  - Journal Article
DEP - 20110301
PL  - United States
TA  - Curr Protoc Mouse Biol
JT  - Current protocols in mouse biology
JID - 101560384
OTO - NOTNLM
OT  - 3R
OT  - animal experimentation
OT  - ethics
OT  - mouse
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2015/06/13 06:00
PHST- 2015/06/13 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - 10.1002/9780470942390.mo100161 [doi]
PST - epublish
SO  - Curr Protoc Mouse Biol. 2011 Mar 1;1(1):155-67. doi:
      10.1002/9780470942390.mo100161.


PMID- 25865513
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150929
LR  - 20150413
IS  - 1608-5906 (Print)
IS  - 1608-5906 (Linking)
VI  - 10 Suppl 1
DP  - 2011
TI  - Risk management in HIV/AIDS: ethical and economic issues associated with
      restricting HAART access only to adherent patients.
PG  - 369-80
LID - 10.2989/16085906.2011.637739 [doi]
AB  - Like many other developing nations, South Africa faces the challenge of
      mobilising resources in response to the HIV pandemic. There is a large budget gap
      between the ideal and the actual amount of funding needed to achieve universal
      access to highly active antiretroviral therapy (HAART). In addition to financial 
      demands, new burdens are being placed on HAART programmes with the emergence of
      HIV drug resistance (HIVDR). Thus, a major threat to successful HAART rollout is 
      HIVDR due to non-adherence to HAART. The use of HAART as a primary and secondary 
      HIV-prevention strategy could be ineffective in situations characterised by high 
      rates of non-adherence. In this context, the research looked at issues related to
      adherence and non-adherence to HAART from the perspective of the provider. Using 
      the software TreeAge Pro 2009, we developed a Markov model to project economic
      outcomes for a hypothetical cohort of HIV/AIDS patients on HAART. The model
      compared two scenarios: adherence and non-adherence to HAART. Input data for the 
      model was obtained from existing literature on HAART uptake in South Africa.
      Moral arguments were analysed and managed through moral reasoning and critical
      thinking. Discounted lifetime costs for adherent and non-adherent HAART patients 
      in South Africa were estimated at US$9 771 and US$14 762, respectively. The model
      showed the loss of 4.55 quality-adjusted life years (QALYs) for non-adherent
      patients, which could be otherwise gained through improved adherence. The
      incremental cost-effectiveness ratio (ICER) indicated that restricting HAART
      access only to adherent patients was the dominant strategy. We suggest that,
      although not a panacea, the withholding or withdrawal of treatment from
      non-adherent individuals as a precautionary intervention has economic and moral
      merit.
FAU - Chawana, Richard
AU  - Chawana R
AD  - a School of Anatomical Sciences , 7 York Road, Parktown 2193 , Johannesburg ,
      South Africa.
FAU - van Bogaert, Donna Knapp
AU  - van Bogaert DK
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - Afr J AIDS Res
JT  - African journal of AIDS research : AJAR
JID - 101146510
OTO - NOTNLM
OT  - South Africa
OT  - adherence
OT  - cost-effectiveness
OT  - economic evaluations
OT  - healthcare
OT  - medical ethics
OT  - modelling
OT  - moral reasoning
OT  - quality of life
OT  - simulation models
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2015/04/14 06:00
PHST- 2015/04/14 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - 10.2989/16085906.2011.637739 [doi]
PST - ppublish
SO  - Afr J AIDS Res. 2011;10 Suppl 1:369-80. doi: 10.2989/16085906.2011.637739.


PMID- 25632370
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2151-805X (Print)
IS  - 2151-805X (Linking)
VI  - 2
IP  - 2
DP  - 2011
TI  - The Ethics of Globalizing Bioethics.
PG  - 147-156
AB  - In the last decade, there have been efforts to globalize the field of bioethics, 
      particularly in developing countries, where biomedical and other research is
      increasingly taking place. We describe and evaluate some key ethical criticisms
      directed towards these initiatives, and argue that while they may be marked by
      ethical, practical, and political tensions and pitfalls, they can nevertheless
      play an important role in stimulating critical bioethics culture in countries
      vulnerable to exploitation by foreign agencies and/or their own authorities.
FAU - Rennie, Stuart
AU  - Rennie S
AD  - Department of Social Medicine & Center for Bioethics, University of North
      Carolina-Chapel Hill.
FAU - Mupenda, Bavon
AU  - Mupenda B
AD  - Centre Interdisciplinaire de Bioethique pour l'Afrique Francophone (CIBAF),
      Kinshasa School of Public Health, Kinshasa, Democratic Republic of Congo.
LA  - eng
GR  - R25 TW007098/TW/FIC NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Ethics Biol Eng Med
JT  - Ethics in biology, engineering & medicine
JID - 101527948
PMC - PMC4306226
MID - NIHMS398605
OTO - NOTNLM
OT  - bioethics
OT  - capacity building
OT  - colonialism
OT  - developing countries
OT  - neo-colonialism
OT  - research ethics
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2015/01/30 06:00
PHST- 2015/01/30 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - 10.1615/EthicsBiologyEngMed.2012004265 [doi]
PST - ppublish
SO  - Ethics Biol Eng Med. 2011;2(2):147-156. doi:
      10.1615/EthicsBiologyEngMed.2012004265.


PMID- 25452941
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141202
LR  - 20200930
IS  - 2276-6944 (Print)
IS  - 2276-6944 (Linking)
VI  - 1
IP  - 1
DP  - 2011 Jan
TI  - Traditional versus orthodox fracture care in uyo, Nigeria.
PG  - 53-67
AB  - Background The general perception in Uyo, the capital city of Akwa-Ibom State, is
      that the populace prefers Traditional Bone Setter (TBS) care to Modern
      Orthopaedic Fracture care. Aims and Objectives Given the option, this study aims 
      to ascertain the attitude of the population on choice between TBS and orthopaedic
      fracture care and identify some of the reasons for such a preference, thus
      providing a basis for improving orthodox care delivery and increasing patronage
      of same. Design of the study This is a prospective observational study, using
      self-administered pre-tested questionnaires. Setting The study was carried out in
      two sites - the General Out-patient Department of the University of Uyo Teaching 
      Hospital (UUTH) and in the major town based public transport park in Uyo.
      Materials and Methods This study was carried out on two populations: one in the
      General Out-patient Department of the University of Uyo Teaching Hospital over a 
      three-day period, and the other in the general Uyo community over a five-day
      period, using a self-administered pre-tested questionnaire. The required sample
      size was determined to be 24 for both populations, using the Statcalc domain of
      Epi-info 3.4.1. However, 95 respondents were recruited into the GOP arm and 150
      into the Community group. Consent for the study was obtained from the Ethical
      Research Board of the Hospital. Results Sixty percent (60%) of our hospital
      clients will opt for hospital care if they sustain a fracture. In the community, 
      64% prefer TBS treatment for a fracture, while 36% prefer hospital care for the
      same problem. When both sets of data were combined 134 people (54.7%) preferred
      TBS care. There was a positive correlation between the preference for hospital
      care and the highest level of education that the person achieved. People in the
      community indicated that the fear of a limb amputation was their main reason for 
      preferring TBS care, if they or a relation sustained a fracture. Conclusion This 
      study shows a greater preference for TBS care in Uyo, due to the fear of
      amputation, the long time to see the doctor, a presumed high cost of orthodox
      care and a lack of formal education. Religious concerns and the duration of care 
      are not important determinants. Reducing the waiting time for seeing a doctor and
      the immediate cost of orthopaedic care; improving the patient - doctor
      relationship and public enlightenment about the processes of medical care
      (especially to allay the fear of amputation), will help to improve the proportion
      of the Uyo populace, who access and benefit from Orthopaedic fracture care.
FAU - Nottidge, Te
AU  - Nottidge T
AD  - University of Uyo Teaching Hospital, Department of Surgery Nigeria.
FAU - Akpanudo, Ei
AU  - Akpanudo E
AD  - University of Uyo Teaching Hospital, Uyo Department of Surgery, Nigeria.
FAU - Akinbami, O
AU  - Akinbami O
AD  - University of Uyo Teaching Hospital, Uyo Department of Surgery, Nigeria.
LA  - eng
PT  - Journal Article
PL  - India
TA  - J West Afr Coll Surg
JT  - Journal of the West African College of Surgeons
JID - 101597958
PMC - PMC4170254
OTO - NOTNLM
OT  - Fracture care
OT  - Nigeria
OT  - Orthodox
OT  - Preference
OT  - Traditional
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2014/12/03 06:00
PHST- 2014/12/03 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
PST - ppublish
SO  - J West Afr Coll Surg. 2011 Jan;1(1):53-67.


PMID- 25356438
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
VI  - 14
IP  - 2
DP  - 2011
TI  - Indian Student Involvement in Tribal Community-Based Research: Underage Drinking 
      Prevention among Rural Native Californians.
LID - http://www.marshall.edu/jrcp/ARCHIVES/V14N2/14.2%20-%20Lee%20and%20Moore.pdf
      [pii]
AB  - The critical need for increased numbers of American Indian/Alaska Native
      scientists and health professionals motivated the development of the California
      Native American Research Center for Health (CA-NARCH) initiative. One strategy of
      the initiative has been to encourage opportunities for applied research
      experiences for American Indian/Alaska Native students. Placement of CA-NARCH
      students in funded research assistant positions for a research project
      "Preventing Underage Drinking by Southwest California Indians: Building Capacity"
      based at the Southern California Tribal Health Clinic, Inc., in a rural part of
      Southern California, provides a model in which both American Indian//Alaska
      Native students and research investigators have benefitted. Six students received
      training in research ethics, data collection methods and data management and
      analysis. The students' participation in project activities has resulted in
      positive experiences for themselves, a productive research staff for the project 
      and positive responses from community members to this sensitive research project.
FAU - Lee, Juliet P
AU  - Lee JP
FAU - Calac, Daniel
AU  - Calac D
FAU - Montag, Annika C
AU  - Montag AC
FAU - Brodine, Stephanie
AU  - Brodine S
FAU - Luna, Juan A
AU  - Luna JA
FAU - Flores, Rosalie Y
AU  - Flores RY
FAU - Gilder, David A
AU  - Gilder DA
FAU - Moore, Roland S
AU  - Moore RS
LA  - eng
GR  - R01 AA016479/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - J Rural Community Psychol
JT  - Journal of rural community psychology (Online)
JID - 101561578
PMC - PMC4209599
MID - NIHMS467520
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2014/10/31 06:00
PHST- 2014/10/31 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
PST - ppublish
SO  - J Rural Community Psychol. 2011;14(2).


PMID- 25309805
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 2150-7716 (Print)
IS  - 2150-7724 (Linking)
VI  - 2
IP  - 4
DP  - 2011
TI  - An Empirical Ethics Agenda for Psychiatric Research Involving Prisoners.
PG  - 18-25
AB  - In the past 30 years, the incarcerated population in the United States has more
      than quadrupled to 2.3 million adults. With an alarmingly high prevalence of
      mental illness, substance use, and other serious health conditions compounding
      their curtailed autonomy, prisoners constitute perhaps the nation's most
      disadvantaged group. Scientifically rigorous research involving prisoners holds
      the potential to inform and enlighten correctional policy and to improve their
      treatment. At the same time, prisoner research presents significant ethical
      challenges to investigators and institutional review boards (IRBs) alike, by
      subjecting participants to conditions that potentially undermine the validity of 
      their informed consent. In 2006, the Institute of Medicine Committee on Ethical
      Considerations for Revisions to the Department of Health and Human Services
      (DHHS) Regulations for Protection of Prisoners Involved in Research recommended
      both further protections and a more permissive approach to research review that
      would allow inmates greater access to potentially beneficial research. These
      recommendations have sparked renewed debate about the ethical trade-offs inherent
      to prisoner research. In this article, the authors review the major
      justifications for research with prisoner subjects and the associated ethical
      concerns, and argue that the field of empirical ethics has much to offer to the
      debate. They then propose a framework for prioritizing future empirical ethics
      inquiry on this understudied topic.
FAU - Christopher, Paul P
AU  - Christopher PP
AD  - University of Massachusetts Medical School.
FAU - Candilis, Philip J
AU  - Candilis PJ
AD  - University of Massachusetts Medical School.
FAU - Rich, Josiah D
AU  - Rich JD
AD  - Alpert Medical School, Brown University, and The Miriam Hospital.
FAU - Lidz, Charles W
AU  - Lidz CW
AD  - University of Massachusetts Medical School.
LA  - eng
GR  - K24 DA022112/DA/NIDA NIH HHS/United States
GR  - P30 AI042853/AI/NIAID NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - AJOB Prim Res
JT  - AJOB primary research
JID - 101520734
PMC - PMC4191925
MID - NIHMS383001
OTO - NOTNLM
OT  - informed consent
OT  - mental disorders
OT  - prisoners
OT  - research ethics
OT  - research ethics committees
OT  - substance use disorders
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2014/10/14 06:00
PHST- 2014/10/14 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - 10.1080/21507716.2011.627082 [doi]
PST - ppublish
SO  - AJOB Prim Res. 2011;2(4):18-25. doi: 10.1080/21507716.2011.627082.


PMID- 25285236
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 2150-7716 (Print)
IS  - 2150-7724 (Linking)
VI  - 2
IP  - 2
DP  - 2011
TI  - The Myth of Community Differences as the Cause of Variations Among IRBs.
PG  - 24-33
AB  - BACKGROUND: Although variations among institutional review boards (IRBs) have
      been documented for 30 years, they continue, raising crucial questions as to why 
      they persist as well as how IRBs view and respond to these variations. METHODS:
      In-depth, 2-hour interviews were conducted with 46 IRB chairs, administrators,
      and members. The leadership of 60 U.S. IRBs were contacted (every fourth one in
      the list of the top 240 institutions by NIH funding). IRB leaders from 34 of
      these institutions were interviewed (response rate = 55%). RESULTS: The
      interviewees suggest that differences often persist because IRBs think these are 
      legitimate, and regulations permit variations due to differing "community
      values." Yet, these variations frequently appear to stem more from differences in
      institutional and subjective personality factors, and from "more eyes" examining 
      protocols, trying to foresee all potential future logistical problems, than from 
      the values of the communities from which research participants are drawn.
      However, IRBs generally appear to defend these variations as reflecting
      underlying differences in community norms. CONCLUSIONS: These data pose critical 
      questions for policy and practice. Attitudinal changes and education among IRBs, 
      principal investigators (PIs), policymakers, and others and research concerning
      these issues are needed.
FAU - Klitzman, Robert
AU  - Klitzman R
AD  - Columbia University.
LA  - eng
GR  - G13 LM009996/LM/NLM NIH HHS/United States
GR  - R01 HG004214/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - AJOB Prim Res
JT  - AJOB primary research
JID - 101520734
PMC - PMC4181844
MID - NIHMS433395
OTO - NOTNLM
OT  - attitudes
OT  - culture
OT  - ethics
OT  - policy
OT  - qualitative research
OT  - regulation
OT  - research ethics
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2014/10/07 06:00
PHST- 2014/10/07 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - 10.1080/21507716.2011.601284 [doi]
PST - ppublish
SO  - AJOB Prim Res. 2011;2(2):24-33. doi: 10.1080/21507716.2011.601284.


PMID- 25013589
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140711
LR  - 20211021
IS  - 2008-6482 (Print)
IS  - 2008-6482 (Linking)
VI  - 2
IP  - 1
DP  - 2011
TI  - Psychiatric aspects of organ transplantation.
PG  - 9-19
AB  - Surgical transplantation of human organs from deceased as well as living donors
      to sick and dying patients began after the Second World War. Over the past 50
      years the transplantation of human organs, tissues and cells has become a
      worldwide practice which has extended, and greatly enhanced the quality of
      hundreds of thousands of lives. The field of transplantation medicine provides an
      important chance for liaison between psychiatric professionals and other
      transplant physicians and surgeons. The discrepancy between the ever-increasing
      demand for organs but the decreasing supply makes it important to evaluate and
      prioritize individuals who are in dire need of the organ. However, this also
      gives rise to certain ethical questions. The following paper discusses various
      psychiatric aspects of organ transplantation in general.
FAU - Kalra, G
AU  - Kalra G
AD  - Assistant Professor.
FAU - Desousa, A
AU  - Desousa A
AD  - Consultant Psychiatrist, Visiting Honorary Consultant, Department of Psychiatry, 
      Lokmanya Tilak Municpal Medical College and General Hospital Mumbai, India.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Iran
TA  - Int J Organ Transplant Med
JT  - International journal of organ transplantation medicine
JID - 101535773
PMC - PMC4089246
OTO - NOTNLM
OT  - Donor
OT  - Organ transplantation
OT  - Organs
OT  - Psychiatric aspects
OT  - Recipient
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2014/07/12 06:00
PHST- 2014/07/12 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
PST - ppublish
SO  - Int J Organ Transplant Med. 2011;2(1):9-19.


PMID- 24956301
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20211021
IS  - 2079-4983 (Print)
IS  - 2079-4983 (Linking)
VI  - 2
IP  - 3
DP  - 2011 Aug 4
TI  - Controlled Positioning of Cells in Biomaterials-Approaches Towards 3D Tissue
      Printing.
PG  - 119-54
LID - 10.3390/jfb2030119 [doi]
AB  - Current tissue engineering techniques have various drawbacks: they often
      incorporate uncontrolled and imprecise scaffold geometries, whereas the current
      conventional cell seeding techniques result mostly in random cell placement
      rather than uniform cell distribution. For the successful reconstruction of
      deficient tissue, new material engineering approaches have to be considered to
      overcome current limitations. An emerging method to produce complex biological
      products including cells or extracellular matrices in a controlled manner is a
      process called bioprinting or biofabrication, which effectively uses principles
      of rapid prototyping combined with cell-loaded biomaterials, typically hydrogels.
      3D tissue printing is an approach to manufacture functional tissue layer-by-layer
      that could be transplanted in vivo after production. This method is especially
      advantageous for stem cells since a controlled environment can be created to
      influence cell growth and differentiation. Using printed tissue for
      biotechnological and pharmacological needs like in vitro drug-testing may lead to
      a revolution in the pharmaceutical industry since animal models could be
      partially replaced by biofabricated tissues mimicking human physiology and
      pathology. This would not only be a major advancement concerning rising ethical
      issues but would also have a measureable impact on economical aspects in this
      industry of today, where animal studies are very labor-intensive and therefore
      costly. In this review, current controlled material and cell positioning
      techniques are introduced highlighting approaches towards 3D tissue printing.
FAU - Wust, Silke
AU  - Wust S
AD  - Institute for Biomechanics, ETH Zurich, 8093 Zurich, Switzerland.
      siwuest@ethz.ch.
FAU - Muller, Ralph
AU  - Muller R
AD  - Institute for Biomechanics, ETH Zurich, 8093 Zurich, Switzerland. ram@ethz.ch.
FAU - Hofmann, Sandra
AU  - Hofmann S
AD  - Institute for Biomechanics, ETH Zurich, 8093 Zurich, Switzerland.
      sahofmann@ethz.ch.
LA  - eng
PT  - Journal Article
DEP - 20110804
PL  - Switzerland
TA  - J Funct Biomater
JT  - Journal of functional biomaterials
JID - 101570734
PMC - PMC4030943
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2014/06/24 06:00
PHST- 2011/05/26 00:00 [received]
PHST- 2011/06/29 00:00 [revised]
PHST- 2011/07/12 00:00 [accepted]
PHST- 2014/06/24 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - jfb2030119 [pii]
AID - 10.3390/jfb2030119 [doi]
PST - epublish
SO  - J Funct Biomater. 2011 Aug 4;2(3):119-54. doi: 10.3390/jfb2030119.


PMID- 24941654
OWN - NLM
STAT- MEDLINE
DCOM- 20140703
LR  - 20161125
IS  - 0076-6011 (Print)
IS  - 0076-6011 (Linking)
VI  - 128
DP  - 2011-2012
TI  - Ethical issues in end of life care.
PG  - 46-51
FAU - Jones, David
AU  - Jones D
LA  - eng
PT  - Journal Article
PL  - England
TA  - Trans Med Soc Lond
JT  - Transactions of the Medical Society of London
JID - 7506118
SB  - IM
MH  - *Attitude to Health
MH  - Humans
MH  - Terminal Care/*ethics/legislation & jurisprudence/methods
MH  - United Kingdom
EDAT- 2011/01/01 00:00
MHDA- 2014/07/06 06:00
CRDT- 2014/06/20 06:00
PHST- 2014/06/20 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2014/07/06 06:00 [medline]
PST - ppublish
SO  - Trans Med Soc Lond. 2011-2012;128:46-51.


PMID- 24917253
OWN - NLM
STAT- MEDLINE
DCOM- 20170111
LR  - 20191112
IS  - 1929-6339 (Electronic)
IS  - 1488-917X (Linking)
VI  - 11 Spec No
DP  - 2011
TI  - Psychosocial and biological indicators in the evaluation of and intervention in
      mental health problems at work.
PG  - 6-19
AB  - This article discusses how biological and psychosocial perspectives might
      integrate into a unified framework - the bio-psychosocial model - that can be
      used to explain how mental health problems at work are generated and that can be 
      subsequently employed in workplace intervention. It concludes with a brief review
      of the advantages and ethical pitfalls that arise with this approach.
CI  - Copyright (c) 2011 Longwoods Publishing.
FAU - Marchand, Alain
AU  - Marchand A
AD  - PhD, School of Industrial Relations, Public Health Research Institute, University
      of Montreal.
FAU - Durand, Pierre
AU  - Durand P
AD  - PhD, School of Industrial Relations, Public Health Research Institute, University
      of Montreal.
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Canada
TA  - Healthc Pap
JT  - HealthcarePapers
JID - 100961305
RN  - EC 3.2.1.1 (alpha-Amylases)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Burnout, Professional/prevention & control
MH  - Depression/prevention & control
MH  - Female
MH  - Humans
MH  - Hydrocortisone/analysis
MH  - Male
MH  - Mental Disorders/*prevention & control
MH  - Saliva/chemistry
MH  - Stress, Psychological/*physiopathology/psychology
MH  - Workplace
MH  - alpha-Amylases/analysis
EDAT- 2011/01/01 00:00
MHDA- 2017/01/12 06:00
CRDT- 2014/06/12 06:00
PHST- 2014/06/12 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2017/01/12 06:00 [medline]
AID - 10.12927/hcpap.2011.22407 [doi]
PST - ppublish
SO  - Healthc Pap. 2011;11 Spec No:6-19. doi: 10.12927/hcpap.2011.22407.


PMID- 24851179
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140522
LR  - 20220311
IS  - 2008-076X (Print)
IS  - 2008-0778 (Linking)
VI  - 4
IP  - 4
DP  - 2011 Jan
TI  - Gamete and embryo donation and surrogacy in australia: the social context and
      regulatory framework.
PG  - 176-83
AB  - The social and legal acceptability of third-party reproduction varies around the 
      world. In Australia, gamete and embryo donation and surrogacy are permitted
      within the regulatory framework set out by federal and state governments. The aim
      of this paper is to describe the social context and regulatory framework for
      third-party reproduction in Australia. This is a review of current laws and
      regulations related to third-party reproduction in Australia. Although subtle
      between-state differences exist, third-party reproduction is by and large a
      socially acceptable and legally permissible way to form a family throughout
      Australia. The overarching principles that govern the practice of third-party
      reproduction are altruism; the right of donorconceived people to be informed of
      their biological origins; and the provision of comprehensive counselling about
      the social, psychological, physical, ethical, financial and legal implications of
      third-party reproduction to those considering donating or receiving gametes or
      embryos and entering surrogacy arrangements. These principles ensure that donors 
      are not motivated by financial gain, donor offspring can identify and meet with
      the person or persons who donated gametes or embryos, and prospective donors and 
      recipients are aware of and have carefully considered the potential consequences 
      of third-party reproduction. Australian state laws and federal guidelines
      prohibit commercial and anonymous third-party reproduction; mandate counselling
      of all parties involved in gamete and embryo donation and surrogacy arrangements;
      and require clinics to keep records with identifying and non- identifying
      information about the donor/s to allow donor-conceived offspring to trace their
      biological origins.
FAU - Hammarberg, Karin
AU  - Hammarberg K
AD  - Melbourne School of Population Health, The University of Melbourne, Melbourne,
      Australia.
FAU - Johnson, Louise
AU  - Johnson L
AD  - Victorian Assisted Reproductive Treatment Authority, Melbourne, Australia.
FAU - Petrillo, Tracey
AU  - Petrillo T
AD  - Victorian Assisted Reproductive Treatment Authority, Melbourne, Australia.
LA  - eng
PT  - Journal Article
DEP - 20110220
PL  - Iran
TA  - Int J Fertil Steril
JT  - International journal of fertility & sterility
JID - 101487941
PMC - PMC4023505
OTO - NOTNLM
OT  - Gamete Donation
OT  - Legal Aspects
OT  - Psychosocial Aspects
OT  - Review
OT  - Surrogate Mothers
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2014/05/23 06:00
PHST- 2010/04/10 00:00 [received]
PHST- 2010/10/20 00:00 [accepted]
PHST- 2014/05/23 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
PST - ppublish
SO  - Int J Fertil Steril. 2011 Jan;4(4):176-83. Epub 2011 Feb 20.


PMID- 24753868
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140422
LR  - 20211021
IS  - 2032-0418 (Print)
IS  - 2032-0418 (Linking)
VI  - 3
IP  - 3
DP  - 2011
TI  - The fetal patient -- ethical aspects of fetal therapy.
PG  - 221-7
AB  - The pregnant patient is a vulnerable subject, and even more so when a serious
      fetal condition is diagnosed. (Invasive) fetal therapy should only be offered
      when there is a good chance that the life of the fetus will be saved, or
      irreversible damage by the disease or disability is prevented. Following
      diagnosis of a potentially treatable condition, the patient needs to be referred 
      to a center with sufficient expertise in diagnosis and all therapeutic options.
      Preferences of the physician towards one or another antenatal intervention is not
      at stake prior to that moment. When fetal therapy is justified--, it should be
      offered with full respect for maternal choice and individual assessment and
      perception of potential-- risks, and should be at the location where there is
      sufficient expertise. For therapies of unproven benefit, the absence of evidence 
      must be disclosed, and therapy should only be undertaken with full voluntary
      consent of the mother. These ought to be undertaken within well designed and
      approved trials and only by experts in the treatment modality. Potential risks
      and eventual morbidities in case of therapeutic failure should be part of the
      counselling, neither-- should fetal therapy be presented as an alternative to
      termination of pregnancy.
FAU - Deprest, J
AU  - Deprest J
AD  - Department of Woman and Child, University Hospitals Leuven, Katholieke
      Universiteit Leuven, Leuven, Belgium;
FAU - Toelen, J
AU  - Toelen J
AD  - Department of Woman and Child, University Hospitals Leuven, Katholieke
      Universiteit Leuven, Leuven, Belgium;
FAU - Debyser, Z
AU  - Debyser Z
AD  - Division of Molecular Medicine, University Hospitals Leuven, Katholieke
      Universiteit Leuven, Leuven, Belgium;
FAU - Rodrigues, C
AU  - Rodrigues C
AD  - Department of Obstetrics and Gynaecology, University Medical Centre Groningen,
      The Netherlands.
FAU - Devlieger, R
AU  - Devlieger R
AD  - Department of Woman and Child, University Hospitals Leuven, Katholieke
      Universiteit Leuven, Leuven, Belgium;
FAU - De Catte, L
AU  - De Catte L
AD  - Department of Woman and Child, University Hospitals Leuven, Katholieke
      Universiteit Leuven, Leuven, Belgium;
FAU - Lewi, L
AU  - Lewi L
AD  - Department of Woman and Child, University Hospitals Leuven, Katholieke
      Universiteit Leuven, Leuven, Belgium;
FAU - Van Mieghem, T
AU  - Van Mieghem T
AD  - Department of Woman and Child, University Hospitals Leuven, Katholieke
      Universiteit Leuven, Leuven, Belgium;
FAU - Naulaers, G
AU  - Naulaers G
AD  - Department of Woman and Child, University Hospitals Leuven, Katholieke
      Universiteit Leuven, Leuven, Belgium;
FAU - Vandevelde, M
AU  - Vandevelde M
AD  - Department of Anesthesiology, University Hospitals Leuven, Katholieke
      Universiteit Leuven, Leuven, Belgium;
FAU - Claus, F
AU  - Claus F
AD  - Department of Medical Imaging, University Hospitals Leuven, Katholieke
      Universiteit Leuven, Leuven, Belgium;
FAU - Dierickx, K
AU  - Dierickx K
AD  - Centre for Bio-medical Ethics and Law, University Hospitals Leuven, Katholieke
      Universiteit Leuven, Leuven, Belgium;
LA  - eng
PT  - Journal Article
PL  - Belgium
TA  - Facts Views Vis Obgyn
JT  - Facts, views & vision in ObGyn
JID - 101578773
PMC - PMC3991449
OTO - NOTNLM
OT  - Fetal therapy
OT  - fetal surgery
OT  - fetoscopy
OT  - informed consent
OT  - prenatal diagnosis
OT  - termination of -pregnancy
OT  - trial
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2014/04/23 06:00
PHST- 2014/04/23 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
PST - ppublish
SO  - Facts Views Vis Obgyn. 2011;3(3):221-7.


PMID- 24710140
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140408
LR  - 20211021
IS  - 2073-4425 (Print)
IS  - 2073-4425 (Linking)
VI  - 2
IP  - 1
DP  - 2011 Jan 14
TI  - Prospects and limitations of using endogenous neural stem cells for brain
      regeneration.
PG  - 107-30
LID - 10.3390/genes2010107 [doi]
AB  - Neural stem cells (NSCs) are capable of producing a variety of neural cell types,
      and are indispensable for the development of the mammalian brain. NSCs can be
      induced in vitro from pluripotent stem cells, including embryonic stem cells and 
      induced-pluripotent stem cells. Although the transplantation of these exogenous
      NSCs is a potential strategy for improving presently untreatable neurological
      conditions, there are several obstacles to its implementation, including
      tumorigenic, immunological, and ethical problems. Recent studies have revealed
      that NSCs also reside in the adult brain. The endogenous NSCs are activated in
      response to disease or trauma, and produce new neurons and glia, suggesting they 
      have the potential to regenerate damaged brain tissue while avoiding the
      above-mentioned problems. Here we present an overview of the possibility and
      limitations of using endogenous NSCs in regenerative medicine.
FAU - Kaneko, Naoko
AU  - Kaneko N
AD  - Department of Developmental and Regenerative Biology, Institute of Molecular
      Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya,
      Aichi 467-8601, Japan. naokoka@med.nagoya-cu.ac.jp.
FAU - Kako, Eisuke
AU  - Kako E
AD  - Department of Developmental and Regenerative Biology, Institute of Molecular
      Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya,
      Aichi 467-8601, Japan. ekako@med.nagoya-cu.ac.jp.
FAU - Sawamoto, Kazunobu
AU  - Sawamoto K
AD  - Department of Developmental and Regenerative Biology, Institute of Molecular
      Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya,
      Aichi 467-8601, Japan. sawamoto@med.nagoya-cu.ac.jp.
LA  - eng
PT  - Journal Article
DEP - 20110114
PL  - Switzerland
TA  - Genes (Basel)
JT  - Genes
JID - 101551097
PMC - PMC3924842
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2014/04/09 06:00
PHST- 2010/11/26 00:00 [received]
PHST- 2010/12/06 00:00 [revised]
PHST- 2011/01/04 00:00 [accepted]
PHST- 2014/04/09 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - genes2010107 [pii]
AID - 10.3390/genes2010107 [doi]
PST - epublish
SO  - Genes (Basel). 2011 Jan 14;2(1):107-30. doi: 10.3390/genes2010107.


PMID- 24693180
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140620
LR  - 20200929
IS  - 0973-7154 (Print)
IS  - 0973-7154 (Linking)
VI  - 7
IP  - 2
DP  - 2011
TI  - Repair of Cartilage injuries using in vitro engineered 3D cartilage tissue-
      Preliminary Results of Our Animal Studies.
PG  - 93
AB  - INTRODUCTION: The cartilage injuries demand novel therapeutic approaches as the
      success rates of the current conventional strategies for the repair of injured
      articular cartilages are not that encouraging. Earlier we have reported that the 
      Thermoreversible Gelation Polymer (TGP) is an ideal scaffold for human
      chondrocyte expansion in vitro. In this study, we report the preliminary results 
      of the in vitro expansion, characterization and experimental in vivo
      transplantation of chondrocytes in a rabbit model of cartilage injury. MATERIALS 
      & METHODS: Nine rabbits were included in this study scheduled for two years,
      after approval by the ethics committee. In the first animal, Chondrocytes were
      isolated from the weight bearing area of patellar groove in the left hindlimb and
      cultured in TGP Scaffold and maintained at 37 degrees C in 5% carbon dioxide
      incubator for 64 days without growth factors. Then the TGP-Chondrocyte construct 
      was transplanted into an experimental defect created in the knee of the right
      forelimb of the same rabbit. After a period of 10 weeks, a biopsy was taken from 
      the transplanted region and subjected to morphological analysis, characterization
      by histopathology (H&E stain) and Immunohistochemistry (S-100 staining). RESULTS:
      The chondrocytes in the 3D TGP culture had round to oval shaped morphology
      without any de-differentiation which is otherwise observed in Conventional 2D
      cultures. A macroscopic structure which resembled cartilage was appreciated in
      the TGP construct in vitro after 64 days which was then transplanted to the
      rabbit. The H&E and Immunohistochemistry studies confirmed the presence of
      chondrocytes in the biopsy tissue. CONCLUSION: Based on the results, we conclude 
      that the TGP significantly supports the in vitro expansion of chondrocytes for a 
      longer period and the 3D culture using TGP preserves the phenotype of the
      articular chondrocytes. The tissue thus grown when implanted with the TGP has
      engrafted well without any adverse reactions and upon confirmation of safety
      following completion of the entire study with adequate follow-up, human
      applications could be considered.
FAU - Arumugam, S
AU  - Arumugam S
AD  - Dept. of Arthroscopy & Sports Medicine, Sri Ramachandra University , Chennai,
      India.
FAU - Manjunath, S
AU  - Manjunath S
AD  - Nichi-In Centre for Regenerative Medicine , Chennai, India.
FAU - Senthilkumar, R
AU  - Senthilkumar R
AD  - Nichi-In Centre for Regenerative Medicine , Chennai, India.
FAU - Rajendiran, S
AU  - Rajendiran S
AD  - Central Laboratory, Sri Ramachandra University , Chennai, India.
FAU - Yoshioka, H
AU  - Yoshioka H
AD  - Waseda University , Tokyo, Japan.
FAU - Mori, Y
AU  - Mori Y
AD  - Waseda University , Tokyo, Japan.
FAU - Abraham, S
AU  - Abraham S
AD  - Nichi-In Centre for Regenerative Medicine , Chennai, India ; Yamanashi
      University-School of Medicine , Chuo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20111030
PL  - India
TA  - J Stem Cells Regen Med
JT  - Journal of stem cells & regenerative medicine
JID - 101552911
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2014/04/03 06:00
PHST- 2014/04/03 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
PST - epublish
SO  - J Stem Cells Regen Med. 2011 Oct 30;7(2):93. eCollection 2011.


PMID- 24634603
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1351-1610 (Print)
IS  - 1351-1610 (Linking)
VI  - 24
IP  - 1-2
DP  - 2011
TI  - Changing methods of disclosure. Literature review of disclosure to children with 
      terminal illnesses, including HIV.
PG  - 199-208
AB  - More than 30 years after the first discovery of the deadly HIV virus, and in the 
      wake of increased knowledge of transmission, treatment and behavioral
      intervention development, parents are still faced with the difficult task of
      whether, when and how to inform their child about her or his HIV status. Except
      for some general ethical considerations, there are no national or international
      guidelines available for handling HIV status disclosure to a child by parents and
      health professionals. Most studies on disclosure address the problem of stigma
      and the barriers to disclosure of HIV-positive status by adults to their sexual
      partners, caretakers, families and communities, but very few studies focus on
      disclosure to HIV-positive children. The majority of the studies that address
      disclosure to children limit themselves to stipulating reasons for barriers to
      such disclosure instead of the skills and knowledge necessary for effective
      disclosure to a child. Increasing availability of therapy for HIV across the
      world presses the issue of disclosure to the child. Even so, disclosure for
      children who are HIV-positive due to vertical transmission continues to be very
      difficult. There is a lack of interventions that consider guidelines for
      healthcare professionals, parents or persons involved with taking care of
      HIV-positive children. These interventions should be designed in an understanding
      manner towards the culture where they might be implemented and be as appropriate 
      in the view of integrating different family structures and the child's
      development.
FAU - Heeren, G Anita
AU  - Heeren GA
AD  - Center for Health Behavior and Communication Research, School of Medicine,
      University of Pennsylvania, Philadelphia, Pennsylvania, USA.
LA  - eng
GR  - R34 MH078803/MH/NIMH NIH HHS/United States
PT  - Journal Article
PL  - England
TA  - Innovation (Abingdon)
JT  - Innovation (Abingdon, England)
JID - 101610057
PMC - PMC3954639
MID - NIHMS479454
OTO - NOTNLM
OT  - HIV vertical transmission
OT  - child
OT  - disclosure
OT  - parent
OT  - stigma
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2014/03/18 06:00
PHST- 2014/03/18 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - 10.1080/13511610.2011.553506 [doi]
PST - ppublish
SO  - Innovation (Abingdon). 2011;24(1-2):199-208. doi: 10.1080/13511610.2011.553506.


PMID- 24591997
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140304
LR  - 20211021
IS  - 1309-0399 (Print)
IS  - 1309-0380 (Linking)
VI  - 12
IP  - 4
DP  - 2011
TI  - Determination of serum CRP, VEGF, Leptin, CK-MB, CA-15-3 and IL-6 levels for
      malignancy prediction in adnexal masses.
PG  - 214-9
LID - 10.5152/jtgga.2011.54 [doi]
AB  - OBJECTIVE: Investigation of serum markers which could be used in the malignancy
      prediction of adnexal masses. MATERIAL AND METHODS: Vascular endothelial growth
      factor (VEGF), interleukin 6 (IL-6), leptin, C-reactive protein (CRP),
      creatine-kinase-MB (CK-MB) and cancer antigen 15-3 (CA 15-3) levels were
      determined prospectively in serum samples that were obtained from patients who
      underwent surgery for an adnexal mass and who were referred to Istanbul
      University, Faculty of Medicine, Department of Obstetrics and Gynecology, between
      2009 and 2011, and then were compared with the serum samples of completely
      healthy outpatient patients as a control group. Based onto the ovarian cancer
      status, cases were divided into four groups: 13 patients were included in the
      early-stage malignant group, 12 patients were included in the advanced-stage
      malignant group, 25 in the benign group and 19 in the healthy control group.
      Patients with only epithelial ovarian cancer were included into the cancer group.
      Ethics Commitee approval was obtained for this study. The budget was supported by
      the Istanbul University Scientific Research Projects Unit. RESULTS: RESULTS
      RELATED WITH SENSITIVITY, SPECIFICITY, POSITIVE PREDICTIVE VALUE (PPV), NEGATIVE 
      PREDICTIVE VALUE (NPV) AND ODDS RATIO (OR), RESPECTIVELY, AND THE FOLLOWING
      VALUES WERE CALCULATED: 48%, 95%, 92%, 59% and +OR 9.6 -OR 0.5 for CA; 15-3; 52%,
      75%, 72%, 55%, +OR 2.08 -OR 0.64 for leptin; 72%, 70%, 75%, 66% 2.4-0.5 for IL-6;
      24%, 80%, 60%, 45%, 1.2-0.92 for VEGF; 68%, 30%, 55%, 43%, 0.97-1.06 for CRP; and
      8%, 70%, 25%, 38%, 026-1.31 for CK-MB. CONCLUSION: CA 15-3, IL-6, Leptin, VEGF
      and CRP were effective in the prediction of benign and malignant masses; however 
      they may be more suitable in selected cases as they have a limited use because of
      their inadequate potential regarding sensitivity and specificity.
FAU - Sen, Serhat
AU  - Sen S
AD  - Department of Obstetrics and Gynecology, Istanbul Faculty of Medicine, Istanbul
      University, Istanbul, Turkey.
FAU - Kuru, Oguzhan
AU  - Kuru O
AD  - Department of Obstetrics and Gynecology, Istanbul Faculty of Medicine, Istanbul
      University, Istanbul, Turkey.
FAU - Akbayir, Ozgur
AU  - Akbayir O
AD  - Department of Obstetrics and Gynecology, Kanuni Sultan Suleyman Research and
      Training Hospital, Istanbul, Turkey.
FAU - Oguz, Hilal
AU  - Oguz H
AD  - Department of Basic Oncology, Institute of Oncology, Istanbul University,
      Istanbul, Turkey.
FAU - Yasasever, Vildan
AU  - Yasasever V
AD  - Department of Basic Oncology, Institute of Oncology, Istanbul University,
      Istanbul, Turkey.
FAU - Berkman, Sinan
AU  - Berkman S
AD  - Department of Obstetrics and Gynecology, Istanbul Faculty of Medicine, Istanbul
      University, Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20111201
PL  - Turkey
TA  - J Turk Ger Gynecol Assoc
JT  - Journal of the Turkish German Gynecological Association
JID - 101272522
PMC - PMC3939252
OTO - NOTNLM
OT  - Adnexal masses
OT  - epithelial ovarian cancer
OT  - malignancy prediction
OT  - serum biomarkers
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2014/03/05 06:00
PHST- 2011/07/12 00:00 [received]
PHST- 2011/09/06 00:00 [accepted]
PHST- 2014/03/05 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - 10.5152/jtgga.2011.54 [doi]
AID - jtgga-12-4-214 [pii]
PST - epublish
SO  - J Turk Ger Gynecol Assoc. 2011 Dec 1;12(4):214-9. doi: 10.5152/jtgga.2011.54.
      eCollection 2011.


PMID- 24591995
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140304
LR  - 20211021
IS  - 1309-0399 (Print)
IS  - 1309-0380 (Linking)
VI  - 12
IP  - 4
DP  - 2011
TI  - Sentinel lymph node biopsy in endometrial cancer: description of the technique
      and preliminary results.
PG  - 204-8
LID - 10.5152/jtgga.2011.52 [doi]
AB  - OBJECTIVE: To measure the feasibility of sentinel lymph node technique in
      endometrial cancer. MATERIAL AND METHODS: The study was designed as a prospective
      non-randomized case-control trial. Between 2010-2011, in Istanbul University,
      Istanbul Medical Faculty, Gynecologic Oncology department, 26 patients who were
      preoperatively evaluated as endometrial cancer enrolled in the study. Patients'
      detailed informed consent and ethics committee approval were obtained. Sentinel
      lymph node (SLN) detection rate was determined as the primary outcome.
      Sensitivity, specificity, positive and negative predictive values and
      particularly false negative results were determined as secondary outcomes. As a
      technique of SLN, injection of methylene blue to the subserosal myometrium of the
      uterine fundus via 5 cc syringe following peritoneal aspiration cytology
      procedure was obtained. Surgery was made after injection for an average of 5
      minutes due to the physiological spread of the blue dye. Then, the standard
      protocol of hysterectomy was performed and the retroperitoneum was opened to
      perform lymphadenectomy. The presence of lymph node regions, and presence of a
      sentinel node was recorded on the trial record form. Positive staining nodes were
      sent separately for pathological examination. In the course of the study due to
      insufficient rate of staining, the technique has been changed to cervical and
      multiple uterine injections. RESULTS: As the primary outcome, an SLN positivity
      rate of 23% in 6 patients with a total of 8 lymph nodes were found. The
      remarkable finding was that in the first technique, the rate was 1/16 (6%), while
      the second technique, 5/10 (50%), respectively. The difference is statistically
      significant (p=0.001). In endometrial cancer stage I and II, secondary outcomes
      for sensitivity, specificity, positive predictive value, negative predictive
      value were 23%, 0%, 100%, 43%, respectively. Because there were no metastatic
      lymph nodes found, false negative rate was 0%. CONCLUSION: SLN approach is not
      valuable enough to eliminate the need for lymphadenectomy. On the other hand, it 
      facilitates scanning micrometastases and ultrastaging, while its clinical value
      has not yet been established. However, according to the recent pilot studies, it 
      provides a means for assessing micrometastases for the medium-risk group for
      local recurrence.
FAU - Kuru, Oguzhan
AU  - Kuru O
AD  - Department of Obstetrics and Gynecology, Istanbul Faculty of Medicine, Istanbul
      University, Istanbul, Turkey.
FAU - Topuz, Samet
AU  - Topuz S
AD  - Department of Obstetrics and Gynecology, Istanbul Faculty of Medicine, Istanbul
      University, Istanbul, Turkey.
FAU - Sen, Serhat
AU  - Sen S
AD  - Department of Obstetrics and Gynecology, Istanbul Faculty of Medicine, Istanbul
      University, Istanbul, Turkey.
FAU - Iyibozkurt, Cem
AU  - Iyibozkurt C
AD  - Department of Obstetrics and Gynecology, Istanbul Faculty of Medicine, Istanbul
      University, Istanbul, Turkey.
FAU - Berkman, Sinan
AU  - Berkman S
AD  - Department of Obstetrics and Gynecology, Istanbul Faculty of Medicine, Istanbul
      University, Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20111201
PL  - Turkey
TA  - J Turk Ger Gynecol Assoc
JT  - Journal of the Turkish German Gynecological Association
JID - 101272522
PMC - PMC3939250
OTO - NOTNLM
OT  - Sentinel lymph node
OT  - endometrium cancer
OT  - surgical staging
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2014/03/05 06:00
PHST- 2011/08/03 00:00 [received]
PHST- 2011/09/16 00:00 [accepted]
PHST- 2014/03/05 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - 10.5152/jtgga.2011.52 [doi]
AID - jtgga-12-4-204 [pii]
PST - epublish
SO  - J Turk Ger Gynecol Assoc. 2011 Dec 1;12(4):204-8. doi: 10.5152/jtgga.2011.52.
      eCollection 2011.


PMID- 24406705
OWN - NLM
STAT- MEDLINE
DCOM- 20151009
LR  - 20140110
IS  - 2157-1740 (Electronic)
IS  - 2157-1740 (Linking)
VI  - 1
IP  - 3
DP  - 2011 Winter
TI  - Advance directives, preemptive suicide and emergency medicine decision making.
PG  - 189-97
LID - 10.1353/nib.2011.0057 [doi]
AB  - As the United States population ages, there is a growing group of aging, elderly,
      individuals who may consider "preemptive suicide"(Prado, 1998). Healthy aging
      patients who preemptively attempt to end their life by suicide and who have
      clearly expressed a desire not to have life -sustaining treatment present a
      clinical and public policy challenge. We describe the clinical, ethical, and
      medical-legal decision making issues that were raised in such a case that
      presented to an academic emergency department. We also review and evaluate a
      decision making process that emergency physicians confront when faced with such a
      challenging and unusual situation .
FAU - Heinrich, Richard L
AU  - Heinrich RL
FAU - Morgan, Marshall T
AU  - Morgan MT
FAU - Rottman, Steven J
AU  - Rottman SJ
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Narrat Inq Bioeth
JT  - Narrative inquiry in bioethics
JID - 101603418
SB  - IM
MH  - Academic Medical Centers
MH  - Advance Directives/*legislation & jurisprudence
MH  - Aged, 80 and over
MH  - Decision Making/*ethics
MH  - Emergency Medicine/*ethics
MH  - Emergency Service, Hospital/ethics
MH  - Fatal Outcome
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Resuscitation/*ethics/methods
MH  - Right to Die/ethics
MH  - Suicide
MH  - Suicide, Attempted/ethics/*psychology
MH  - Time Factors
EDAT- 2011/01/01 00:00
MHDA- 2015/10/10 06:00
CRDT- 2014/01/11 06:00
PHST- 2014/01/11 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2015/10/10 06:00 [medline]
AID - S2157174011300164 [pii]
AID - 10.1353/nib.2011.0057 [doi]
PST - ppublish
SO  - Narrat Inq Bioeth. 2011 Winter;1(3):189-97. doi: 10.1353/nib.2011.0057.


PMID- 24406657
OWN - NLM
STAT- MEDLINE
DCOM- 20151008
LR  - 20140110
IS  - 2157-1740 (Electronic)
IS  - 2157-1740 (Linking)
VI  - 1
IP  - 2
DP  - 2011 Fall
TI  - When ethics consultation and courts collide: a case of compelled treatment of a
      mature minor.
PG  - 123-31
LID - 10.1353/nib.2011.0035 [doi]
AB  - A fourteen year old is diagnosed with aplastic anemia. The teen and his parents
      are Jehovah's Witnesses. An ethics consult is called on the day of admission by
      an ethically sophisticated social worker and attending. The patient and his
      parents see this diagnosis as "a test of their faith." The ethical analysis
      focuses on the mature minor doctrine, i.e. whether the teen has the capacity to
      make this decision. The hospital chooses to take the case to court, with a result
      that is at odds with the ethics consultation recommendations. Ethics was never
      deposed or otherwise invited to be involved with the hearing. Thus the larger
      question of the relation of ethics and law was brought into stark relief.
FAU - Spike, Jeffrey P
AU  - Spike JP
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Narrat Inq Bioeth
JT  - Narrative inquiry in bioethics
JID - 101603418
SB  - IM
MH  - Adolescent
MH  - Anemia, Aplastic/diagnosis/*therapy
MH  - Bioethical Issues
MH  - Blood Transfusion/ethics
MH  - *Decision Making
MH  - Ethics Consultation/*ethics/legislation & jurisprudence
MH  - Ethics, Medical
MH  - Humans
MH  - *Jehovah's Witnesses
MH  - Liability, Legal
MH  - Male
MH  - Minors/legislation & jurisprudence
MH  - Narration
MH  - Personal Autonomy
MH  - Physician-Patient Relations
MH  - Professional-Family Relations
MH  - Treatment Refusal/ethics/*legislation & jurisprudence
EDAT- 2011/01/01 00:00
MHDA- 2015/10/09 06:00
CRDT- 2014/01/11 06:00
PHST- 2014/01/11 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2015/10/09 06:00 [medline]
AID - S2157174011200058 [pii]
AID - 10.1353/nib.2011.0035 [doi]
PST - ppublish
SO  - Narrat Inq Bioeth. 2011 Fall;1(2):123-31. doi: 10.1353/nib.2011.0035.


PMID- 24406529
OWN - NLM
STAT- MEDLINE
DCOM- 20151012
LR  - 20151119
IS  - 2157-1740 (Electronic)
IS  - 2157-1740 (Linking)
VI  - 1
IP  - 1
DP  - 2011 Spring
TI  - Perspectives of adolescents and young adults with cerebral palsy on the ethical
      and social challenges encountered in healthcare services.
PG  - 43-54
LID - 10.1353/nib.2011.0001 [doi]
AB  - Healthcare is a context where individuals with disability confront important
      ethical and social challenges. Adolescents and young adults with cerebral palsy
      (CP) seem to face additional challenges but we have little insight into their
      perspectives. This qualitative study aimed to identify and better understand such
      challenges. We interviewed 14 participants with CP aged 18 to 25. Participants
      described a range of challenges experienced when using health services,
      including: lack of long-term follow-up, shortcomings in physical access to
      infrastructures, and situations of injustice. Challenges specific to medical
      consultations were reported (e.g., rude attitudes, belittlement, inadequate
      communication, lack of consideration). We discuss and explain further that: (1)
      the ethical principle of respect for persons needs to be concretely specified to 
      improve current practices; (2) respect for autonomy calls for further direct
      empowerment of individuals with CP and, (3) gaps in dedicated healthcare
      resources for CP and the long-term needs associated should be addressed.
FAU - Lariviere-Bastien, Danae
AU  - Lariviere-Bastien D
FAU - Majnemer, Annette
AU  - Majnemer A
FAU - Shevell, Michael
AU  - Shevell M
FAU - Racine, Eric
AU  - Racine E
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Narrat Inq Bioeth
JT  - Narrative inquiry in bioethics
JID - 101603418
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cerebral Palsy/diagnosis/*psychology/therapy
MH  - Cohort Studies
MH  - Delivery of Health Care/*ethics/methods
MH  - Disability Evaluation
MH  - Disabled Persons/*rehabilitation
MH  - Female
MH  - Health Services Accessibility/*ethics
MH  - Humans
MH  - Male
MH  - Needs Assessment
MH  - Qualitative Research
MH  - Quality of Health Care/*ethics
MH  - Severity of Illness Index
MH  - Social Adjustment
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2011/01/01 00:00
MHDA- 2015/10/13 06:00
CRDT- 2014/01/11 06:00
PHST- 2014/01/11 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2015/10/13 06:00 [medline]
AID - S2157174011100007 [pii]
AID - 10.1353/nib.2011.0001 [doi]
PST - ppublish
SO  - Narrat Inq Bioeth. 2011 Spring;1(1):43-54. doi: 10.1353/nib.2011.0001.


PMID- 24127056
OWN - NLM
STAT- Publisher
LR  - 20191120
IS  - 1938-2472 (Electronic)
IS  - 0022-0124 (Linking)
VI  - 42
IP  - 1
DP  - 2011 Jan 1
TI  - Empowering Nurses to Participate in Ethical Decision-Making at the Bedside.
PG  - 25-26
LID - 10.3928/00220124-20110101-07 [doi]
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Contin Educ Nurs
JT  - Journal of continuing education in nursing
JID - 0262321
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:00
CRDT- 2013/10/16 06:00
PHST- 2013/10/16 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:00 [medline]
AID - 10.3928/00220124-20110101-07 [doi]
PST - ppublish
SO  - J Contin Educ Nurs. 2011 Jan 1;42(1):25-26. doi: 10.3928/00220124-20110101-07.


PMID- 23908790
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130805
LR  - 20211021
IS  - 2076-9172 (Print)
IS  - 2076-9172 (Linking)
VI  - 2
IP  - 1
DP  - 2011 Jan
TI  - Maimonides' appreciation for medicine.
PG  - e0018
LID - 10.5041/RMMJ.10018 [doi]
AB  - Moses Maimonides, the illustrious medieval rabbi and philosopher, dedicated the
      last decade of his life primarily to medicine. His strong interest in medicine
      was an integral component of his religious-philosophical teachings and world
      view. In this paper various sources from his rabbinic writings are presented that
      explain Maimonides' motivation regarding and deep appreciation for medicine: (A) 
      The physician fulfills the basic biblical obligation to return lost objects to
      their owner, for with his knowledge and experience the physician can restore good
      health to his sick fellow human being; (B) medicine provides a unique opportunity
      to practice imitatio dei, as it reflects the religious duty to maintain a healthy
      life-style; (C) as an important natural science, medicine offers tools to
      recognize, love, and fear God. These three aspects address man's relationship and
      obligation towards his fellow-man, himself and God. Biographical insights
      supported by additional sources from Maimonides' writings are discussed.
FAU - Gesundheit, Benjamin
AU  - Gesundheit B
AD  - Department of Jewish Philosophy, Hebrew University Jerusalem, Israel; and The
      International Center for Cell Therapy & Cancer Immunotherapy (CTCI), Weizmann
      Center, Tel Aviv, Israel.
LA  - eng
PT  - Journal Article
DEP - 20110131
PL  - Israel
TA  - Rambam Maimonides Med J
JT  - Rambam Maimonides medical journal
JID - 101538065
PMC - PMC3678790
OTO - NOTNLM
OT  - Jewish medical ethics
OT  - Maimonides
OT  - motivation for medicine
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2013/08/03 06:00
PHST- 2013/08/03 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - 10.5041/RMMJ.10018 [doi]
AID - rmmj-2-1_e0018 [pii]
PST - epublish
SO  - Rambam Maimonides Med J. 2011 Jan 31;2(1):e0018. doi: 10.5041/RMMJ.10018. Print
      2011 Jan.


PMID- 23908753
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130805
LR  - 20211021
IS  - 2008-0387 (Print)
IS  - 2008-0387 (Linking)
VI  - 4
DP  - 2011
TI  - The challenge of truth telling across cultures: a case study.
PG  - 11
AB  - Accompanied with various opinions across cultures, truth telling is a major
      debate in bioethics. Many studies have focused on attitudes toward truth
      disclosure. We intend to review several relevant research studies, and discuss
      the issue through a clinical case consultation. It seems that while "the right to
      know" is emphasized in bioethics, in some cultural contexts, health professionals
      fear communicating bad news. The patients may not receive information directly,
      because it is believed that the truth may make the patient feel hopeless and
      unable to cope with the problem. Nevertheless, some believe that sharing
      information may strengthen a trusting relationship between patients and medical
      professionals. Extensive efforts are in process in some societies to make patient
      rights to know the truth as a natural part of medical practice. However, in some 
      cases, the principles of respect for patient autonomy require us to accept
      patient's refusal to know the truth, with the provision that he assigns someone
      to receive information and make medical decisions on his behalf. In conclusion,
      it is suggested that healthcare professionals should not act on a unique
      presumption in all cases and they should explore what the real interest of
      patient is, in order to respect individual autonomy.
FAU - Zahedi, Farzaneh
AU  - Zahedi F
AD  - MD, Endocrinology and Metabolism Research Centre, Medical Ethics and History of
      Medicine Research Centre, Tehran University of Medical Sciences, 5th floor,
      Shariati Hospital, North Kargar Avenue, Tehran 14114-13137, Iran, Tel: (+98 21)
      88220037-8, , Email: fzahedi@sina.tums.ac.ir.
LA  - eng
PT  - Journal Article
DEP - 20111227
PL  - Iran
TA  - J Med Ethics Hist Med
JT  - Journal of medical ethics and history of medicine
JID - 101606442
PMC - PMC3713926
OTO - NOTNLM
OT  - Autonomy
OT  - Clinical ethics
OT  - Culture
OT  - Ethics consultation
OT  - Informed consent
OT  - Truth telling
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2013/08/03 06:00
PHST- 2011/02/09 00:00 [received]
PHST- 2011/11/01 00:00 [accepted]
PHST- 2013/08/03 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
PST - epublish
SO  - J Med Ethics Hist Med. 2011 Dec 27;4:11. Print 2011.


PMID- 23908752
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130805
LR  - 20211021
IS  - 2008-0387 (Print)
IS  - 2008-0387 (Linking)
VI  - 4
DP  - 2011
TI  - Ethical concerns in early 21(st) century organ transplantation.
PG  - 10
AB  - Medical ethics is an indispensible and challenging aspect of clinical practice.
      This is particularly prominent in the field of organ transplantation. In this
      paper, initially, a clinical case with brain death that ended up as an organ
      donor will be presented. Following the presentation, important moral challenges
      which initially formed medical ethics and some highlights of it in organ
      transplantation will be discussed in detail. The impact of complex modern
      influential factors that might interfere with the practice of medical ethics in
      this field such as patients' vulnerability, financial temptations, and legal
      regulations will be also dealt with. Finally, we shall propose practical
      guidelines aiming at improving the practice of medical ethics in the emerging
      issue of organ transplantation.
FAU - Waness, Abdelkarim
AU  - Waness A
AD  - MD, CPI, ABIM, FACP, Consultant, Internal Medicine, Sheikh Khalifa Medical City, 
      P.O. Box: 51900, Abu Dhabi, UAE, Telephone: 971-56-7330240, , Email:
      awaness@skmc.ae.
LA  - eng
PT  - Journal Article
DEP - 20111106
PL  - Iran
TA  - J Med Ethics Hist Med
JT  - Journal of medical ethics and history of medicine
JID - 101606442
PMC - PMC3713933
OTO - NOTNLM
OT  - Informed consent
OT  - Organ donation
OT  - Population vulnerability
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2013/08/03 06:00
PHST- 2011/09/07 00:00 [received]
PHST- 2011/10/30 00:00 [accepted]
PHST- 2013/08/03 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
PST - epublish
SO  - J Med Ethics Hist Med. 2011 Nov 6;4:10. Print 2011.


PMID- 23908750
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130805
LR  - 20220410
IS  - 2008-0387 (Print)
IS  - 2008-0387 (Linking)
VI  - 4
DP  - 2011
TI  - Reform in medical ethics curriculum: a step by step approach based on available
      resources.
PG  - 8
AB  - In this project, we aimed to revise the medical ethics curriculum at the School
      of Medicine, Tehran University of Medical Sciences, in order to promote the level
      of students' ethical awareness and enable them to make ethical decisions. Ideal
      and long term educational objectives were set to determine directions for future 
      reforms and to provide a baseline for future evaluation of the project. However, 
      based on limited available recourses, the first stage of the reform was planned
      and implemented with a 3 years scope. In revising the curriculum, which was done 
      according to the Harden's ten questions, we focused on moral attitude and ethical
      reasoning skill in addition to academic knowledge base by using methods such as
      case discussions, portfolio, and clinical ethics rounds. The revised curriculum
      was implemented during the first semester of the 2006-2007 academic year for the 
      first time. The student feedback indicated that the new curriculum was successful
      in increasing the students' awareness of ethical issues and enabled them to
      understand and accept their professional obligations. Revising the curriculum and
      its evaluation should be considered as an ongoing process. The present project
      was a successful experience that motivated faculty members to pursue the next
      steps of improving the curriculum on medical ethics and proved to be convincing
      for the authorities and policy makers to support it.
FAU - Asghari, Fariba
AU  - Asghari F
AD  - Assistant Professor, Medical Ethics and History of Medicine Research Center,
      Tehran University of Medical Sciences.
FAU - Mirzazadeh, Azim
AU  - Mirzazadeh A
FAU - Samadi, Aniseh
AU  - Samadi A
FAU - Safa, Aliakbar Nejati
AU  - Safa AN
FAU - Jafarian, Ali
AU  - Jafarian A
FAU - Farahani, Ali Vasheghani
AU  - Farahani AV
FAU - Razavi, Seyed Hasan Emami
AU  - Razavi SH
LA  - eng
PT  - Journal Article
DEP - 20110814
PL  - Iran
TA  - J Med Ethics Hist Med
JT  - Journal of medical ethics and history of medicine
JID - 101606442
PMC - PMC3713913
OTO - NOTNLM
OT  - Curriculum
OT  - Medical ethics
OT  - Undergraduate medical education
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2013/08/03 06:00
PHST- 2010/11/11 00:00 [received]
PHST- 2011/08/07 00:00 [accepted]
PHST- 2013/08/03 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
PST - epublish
SO  - J Med Ethics Hist Med. 2011 Aug 14;4:8. Print 2011.


PMID- 23908749
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130805
LR  - 20220408
IS  - 2008-0387 (Print)
IS  - 2008-0387 (Linking)
VI  - 4
DP  - 2011
TI  - The Implementation of the Sharia Law in Medical Practice: A Balance between
      Medical Ethics and Patients Rights.
PG  - 7
AB  - As medical ethics indisputably needs to consider patients' religious beliefs and 
      spiritual ideas, one can suggest that hospitals are responsible for not only
      patients' rights and dignity, but also for her/his religious concerns and
      expectations. The current study is designed shed some light on the patients' view
      of the implementation of religious law in Iranian hospitals, specifically, the
      right of patients to be visited and delivered health services by professionals
      from the same sex. This protocol is proposed by the Ministry of Health and
      Medical Education of the Islamic Republic of Iran as a response to the increasing
      demand for implementation of the religious law by Iranian patients. This research
      is a cross-sectional study which was conducted at four teaching general hospitals
      in Tehran, Iran. The data was collected by the means of a questionnaire
      distributed to 120 women who were admitted to different wards of the hospitals.
      These women were asked to express their opinion of the implementation the Same
      Sex Health Care Delivery (SSHCD) system in Iranian hospitals. All analyses were
      performed with the use of SPSS software, version 16.0. The results indicate that 
      half of the hospitalized women believed that being visited by a physician from
      the same gender is necessary who advocated the implementation of SSHCD in a
      clinical setting; and most of their husbands preferred their wives to be visited 
      exclusively by female physicians. This study highlights the view of the Iranian
      patients towards the issue and urges the Ministry of Health and Medical Education
      of the Islamic Republic of Iran to accelerate the implementation of this law.
      SSHCD is what the majority of Iranian patients prefer, and, considering patients'
      rights and the medical ethics, it should be implemented by Iranian policy makers.
FAU - Dargahi, Hossein
AU  - Dargahi H
AD  - Associate Professor of Allied Health Sciences, Tehran University of Medical
      Sciences, 13, Fardaanesh, Qods St., Enghelab Ave, Tehran, Iran, Tel: 0098 - 021 -
      88965608, - 021 - 88997050, E-mail: hdargahi@sina.tums.ac.ir.
LA  - eng
PT  - Journal Article
DEP - 20110727
PL  - Iran
TA  - J Med Ethics Hist Med
JT  - Journal of medical ethics and history of medicine
JID - 101606442
PMC - PMC3713915
OTO - NOTNLM
OT  - Adjustment plan
OT  - Attitude
OT  - Cadaver
OT  - Hospital
OT  - Medical ethics
OT  - Patient's right
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2013/08/03 06:00
PHST- 2010/11/10 00:00 [received]
PHST- 2011/07/15 00:00 [accepted]
PHST- 2013/08/03 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
PST - epublish
SO  - J Med Ethics Hist Med. 2011 Jul 27;4:7. Print 2011.


PMID- 23908748
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130805
LR  - 20211021
IS  - 2008-0387 (Print)
IS  - 2008-0387 (Linking)
VI  - 4
DP  - 2011
TI  - Assessment of professionalism in Iranian pharmacists.
PG  - 6
AB  - In the recent years, the role of a pharmacist has been significantly changed.
      Traditionally, in the late 20(th) century, a pharmacist's role was considered as 
      merely dispensing medication to patients. This view however, has been
      significantly altered, and, today, a pharmacist is supposed to provide patients
      with information regarding the medication they are to take, as well as on
      different aspects of their disease. Therefore, one can suggest that some other
      factors have recently come into play in the daily tasks of a pharmacist such as
      accountability and authority. The current cross-sectional survey is conducted on 
      a cohort of community pharmacists attending a continuing education program. A
      questionnaire comprised of 26 Likert-type scale questions was designed to assess 
      pharmacists' attitude towards professionalism and its subscales which are defined
      later in detail. A total number of 1000 pharmacists were surveyed and 560 of them
      filled and returned the questionnaires. On a scale from 1-5 on which 1 was
      corresponded with strongly agree and 5 with strongly disagree, the total score of
      pharmacists professionalism was 92.9 +/- 10.4 out of 130. As regards the
      subscales, in the subscale of accountability 46.8% of participants, in the
      subscale of altruism 90.1% of participants, in the theme of duty 85.7% of
      participants, and in the subscale of working relationship with physicians 84% of 
      pharmacist achieved more than two third of the total score. Only in term of
      conflict of interest 67.9% of participants scored less than two third (17-25) of 
      the total score. Women obtained significantly higher scores in altruism (P<0.05).
      Furthermore, there was a correlation between age and the score of accountability 
      and working relationship with physicians; and, the same was observed in regards
      with work experience with the score of working relationship with physicians. The 
      employment position affected neither our participants' response to the whole
      questionnaire nor any of subscales. Although the total score for professionalism 
      was not dramatically decreased, the significantly low results are alarming and
      they should be considered more seriously. In order to enhance the level of
      pharmacists' professionalism, especially in some special aspects, it seems
      necessary to conduct similar surveys on pharmacy students and registered
      pharmacists with a more comprehensive questionnaire. Overall, it can be concluded
      that designing a proper teaching course in professionalism for pharmacy students 
      is of paramount importance if we are to promote professionalism in future
      pharmacists.
FAU - Javadi, Mohammadreza
AU  - Javadi M
AD  - Assistant Professor, Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran
      University of Medical Sciences, Tehran, Iran;
FAU - Asghari, Fariba
AU  - Asghari F
FAU - Salari, Pooneh
AU  - Salari P
LA  - eng
PT  - Journal Article
DEP - 20110626
PL  - Iran
TA  - J Med Ethics Hist Med
JT  - Journal of medical ethics and history of medicine
JID - 101606442
PMC - PMC3713883
OTO - NOTNLM
OT  - Accountability
OT  - Altruism
OT  - Pharmacy ethics
OT  - Pharmacy professionalism
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2013/08/03 06:00
PHST- 2011/04/06 00:00 [received]
PHST- 2011/06/11 00:00 [accepted]
PHST- 2013/08/03 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
PST - epublish
SO  - J Med Ethics Hist Med. 2011 Jun 26;4:6. Print 2011.


PMID- 23908747
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130805
LR  - 20220408
IS  - 2008-0387 (Print)
IS  - 2008-0387 (Linking)
VI  - 4
DP  - 2011
TI  - Pharmacy ethics: evaluation pharmacists' ethical attitude.
PG  - 5
AB  - Alterations in pharmacy practice from prescription dispensing to more
      patient-centered relationship intensifies the necessity of clinical
      decision-making. Pharmacists' knowledge as well as ethical reasoning affects
      their clinical decision-making. Unfortunately in Iran pharmacy ethics did not
      develop along with medical ethics and special considerations are of major
      importance. The study was designed to evaluate pharmacists' attitude toward some 
      principles of bioethics. A cross-sectional survey was performed on a sample of
      Iranian pharmacists attended in continuous education programs in 2010. Based on
      the pharmacists' attitude toward common ethical problems, 9 Likert-type scale
      scenarios were designed. A thousand pharmacists were surveyed and 505
      questionnaires were filled. For the whole questionnaire the strongly disagree
      answer was the most ethical answer. On a scale from 1-5 on which 5=strongly
      disagree, the total score of pharmacists ethical attitude was 17.69 +/- 3.57. For
      easier analysis we considered the score of 1 for agree and strongly agree
      answers, score of 2 for neutral answers and score of 3 for disagree and strongly 
      disagree answers. The total score in confidentiality for all participants was
      4.15 +/- 1.45 out of 9, in autonomy 6.25 +/- 1.85 out of 9, in non-maleficence
      5.14 +/- 1.17 out of 6 and in justice was 2.27 +/- 0.89 out of 3, however there
      was no significant difference between men and women in the total score and the
      score of each theme. The older participants (> 40 years) significantly had lower 
      total score (P< 0.05) as well as the score of each theme (P< 0.05), except for
      non-maleficence. The work experience showed impact on the pharmacists' attitude
      toward autonomy and the participants with more than 5 years work experience
      significantly obtained lower score in this theme. Compiling ethical guidelines
      and improving pharmacy ethics curriculum is highly critical to provide the best
      pharmaceutical care and to make clinical decisions in critical situations.
      Therefore further quantitative and qualitative investigations into finding
      pitfalls and challenges in this issue are highly recommended.
FAU - Sharif, Pooneh Salari
AU  - Sharif PS
AD  - Medical Ethics and History of Medicine Research Center, Tehran University of
      Medical Sciences, Tehran, Iran;
FAU - Javadi, Mohammadreza
AU  - Javadi M
FAU - Asghari, Fariba
AU  - Asghari F
LA  - eng
PT  - Journal Article
DEP - 20110502
PL  - Iran
TA  - J Med Ethics Hist Med
JT  - Journal of medical ethics and history of medicine
JID - 101606442
PMC - PMC3714006
OTO - NOTNLM
OT  - Autonomy
OT  - Confidentiality
OT  - Ethical attitude
OT  - Pharmacy ethics
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2013/08/03 06:00
PHST- 2011/02/27 00:00 [received]
PHST- 2011/04/23 00:00 [accepted]
PHST- 2013/08/03 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
PST - epublish
SO  - J Med Ethics Hist Med. 2011 May 2;4:5. Print 2011.


PMID- 23908746
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130805
LR  - 20211021
IS  - 2008-0387 (Print)
IS  - 2008-0387 (Linking)
VI  - 4
DP  - 2011
TI  - Is dissection humane?
PG  - 4
AB  - Dissection is being jeopardized in the modern medical education. It has
      unrelentingly faced the lashes of time and has been the scapegoat for numerous
      convenient curricula reforms and subjective biases. The cadaver is unparallel in 
      establishing core knowledge among the medical community and it needs to be
      appreciated in a new light in the "cyber anatomy" realm of today. This article
      elucidates the medical and ethical validity of continuing human body dissection
      in medicine which outweighs all the prejudices associated with it.
FAU - Hasan, Tabinda
AU  - Hasan T
AD  - Department of anatomy, Faculty of Medicine, Jazan University, Saudi Arabia,
      Email: drtabindahasan@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20110406
PL  - Iran
TA  - J Med Ethics Hist Med
JT  - Journal of medical ethics and history of medicine
JID - 101606442
PMC - PMC3713902
OTO - NOTNLM
OT  - Cadaver
OT  - Dissection
OT  - Education
OT  - Ethics
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2013/08/03 06:00
PHST- 2010/11/23 00:00 [received]
PHST- 2011/03/14 00:00 [accepted]
PHST- 2013/08/03 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
PST - epublish
SO  - J Med Ethics Hist Med. 2011 Apr 6;4:4. Print 2011.


PMID- 23908743
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130805
LR  - 20211021
IS  - 2008-0387 (Print)
IS  - 2008-0387 (Linking)
VI  - 4
DP  - 2011
TI  - Observance of ethical codes in selecting supervisor by postgraduate students.
PG  - 1
AB  - Nowadays, with development of medical sciences, several ethical challenges have
      raised which make research more complicated. Observance of student's right in
      selecting interested research topic and the supervisor, in addition to its
      positive effect on the research process, will cause satisfaction and quality
      promotion in the educational system. To observe that issue, during a confidential
      survey of a number of postgraduate students in 2009, students were asked to
      confidentially describe any displeasure they might get during their study and
      research. The most important items included: imposing thesis by a supervisor
      without informing the student, compulsory assignment of students to a specific
      supervisor, little time allocated for students by the supervising team who may be
      selected without students interests, prolongation of the research time, and
      non-cooperation in publishing the results. Establishment of a proper way to
      transfer student's displeasure or criticism to supervisors and establishing a
      continuous program for informing research teams including supervisors and
      students about ethical codes can positively affect the issue.
FAU - Bayrami, Zahra
AU  - Bayrami Z
AD  - Ethics Committee Secretary, Pharmaceutical Sciences Research Center, Tehran
      University of Medical Sciences, Tehran, Iran.
FAU - Abdollahi, Mohammad
AU  - Abdollahi M
LA  - eng
PT  - Journal Article
DEP - 20110214
PL  - Iran
TA  - J Med Ethics Hist Med
JT  - Journal of medical ethics and history of medicine
JID - 101606442
PMC - PMC3713704
OTO - NOTNLM
OT  - Doctorate students
OT  - Ethics
OT  - Research
OT  - Supervisor
OT  - Thesis
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2013/08/03 06:00
PHST- 2011/01/10 00:00 [received]
PHST- 2011/02/07 00:00 [accepted]
PHST- 2013/08/03 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
PST - epublish
SO  - J Med Ethics Hist Med. 2011 Feb 14;4:1. Print 2011.


PMID- 23807866
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1301-0883 (Print)
IS  - 1301-0883 (Linking)
VI  - 16
IP  - 2
DP  - 2011
TI  - Engaging community to support HIV prevention research.
PG  - 168-177
AB  - Actively engaging communities in effective partnerships is considered critical
      for ethically robust and locally relevant HIV prevention research. This can be
      challenging in developing countries that have little prior experience in this
      area. This paper summarizes processes and lessons learnt while setting up the
      Community Involvement Plan of National AIDS Research Institute, Pune, India.
      Formal partnerships were established with voluntary agencies. The focus was on
      using strategies adapted from participatory learning and action techniques. The
      community program was implemented through peer educators specifically identified 
      from the communities where partner non-governmental organizations function. At
      the grass root level, peer educators imparted education to the common people
      about research studies and helped to implement community based recruitment and
      retention activities. The focus was on facilitating periodic interaction between 
      the outreach workers of the research team and the peers and modifying the
      strategies till they were found locally implementable and appropriate. Through
      adequate time investment, mutually beneficial and respectful partnerships with
      community based organizations and grass root level workers, the community became 
      actively involved in clinical research. The program helped in developing a sense 
      of partnership among the peers for the research conducted by the research
      organization, widening the net of community education and identification of
      research participants. By building trust in the community and implementing
      research within an ethical framework, culturally sensitive matters were
      appropriately addressed. The community involvement process is long, laborious and
      ever-evolving. Effective community engagement requires institutional leadership
      support, adequate funding and commitment by researchers. It is possible to
      sustain such a model in a resource limited setting.
FAU - Sahay, Seema
AU  - Sahay S
AD  - National AIDS Research Institute, 73-G, MIDC, BIE, Post Box 1895 Pune, 411026,
      India.
FAU - Mehendale, Sanjay
AU  - Mehendale S
LA  - eng
GR  - R21 CA113465/CA/NCI NIH HHS/United States
GR  - P30 AI054999/AI/NIAID NIH HHS/United States
GR  - U01 AI069417/AI/NIAID NIH HHS/United States
GR  - UM1 AI069417/AI/NIAID NIH HHS/United States
GR  - D43 TW001035/TW/FIC NIH HHS/United States
PT  - Journal Article
PL  - Turkey
TA  - East J Med
JT  - Eastern journal of medicine : EJM
JID - 9710008
PMC - PMC3691695
MID - NIHMS372563
OTO - NOTNLM
OT  - Community involvement
OT  - HIV prevention
OT  - NGO
OT  - community advisory board (CAB)
OT  - partnership
OT  - research
OT  - trial
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2013/06/29 06:00
PHST- 2013/06/29 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
PST - ppublish
SO  - East J Med. 2011;16(2):168-177.


PMID- 23754904
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130612
LR  - 20211021
IS  - 1179-142X (Print)
IS  - 1179-142X (Linking)
VI  - 4
DP  - 2011
TI  - Controversial treatment of a victim of severe head injury complicated by septic
      shock and acute respiratory distress syndrome.
PG  - 41-6
LID - 10.2147/IMCRJ.S21249 [doi]
AB  - Pneumonia, severe sepsis, and acute respiratory distress syndrome (ARDS) are
      frequent complications after head trauma. Recombinant human activated protein C
      (APC) reportedly improves circulation and respiration in severe sepsis, but is
      contraindicated after head injury because of increased risk of intracranial
      bleeding. A 21-year-old man with severe head injury after a car accident was
      endotracheally intubated, mechanically ventilated, and hemodynamically stabilized
      before transfer to our university hospital. His condition became complicated with
      pneumonia, septic shock, ARDS, coagulation dysfunction, and renal failure. In
      spite of intensive therapy, oxygenation and arterial blood pressure fell to
      critically low values. Simultaneously, his intracranial pressure peaked and his
      pupils dilated, displaying no reflexes to light. His antibiotic regimen was
      changed and ventilation was altered to high frequency oscillations, and despite
      being ethically problematic, we added APC to his treatment. The patient recovered
      with modest neurological sequelae.
FAU - Haavind, Anniken
AU  - Haavind A
AD  - Division of Intensive Care Medicine, Department of Anesthesiology, University
      Hospital of North Norway, Tromso, Norway.
FAU - Hevroy, Olav
AU  - Hevroy O
FAU - Hennig, Rune
AU  - Hennig R
FAU - Bjertnaes, Lars
AU  - Bjertnaes L
LA  - eng
PT  - Case Reports
DEP - 20110629
PL  - New Zealand
TA  - Int Med Case Rep J
JT  - International medical case reports journal
JID - 101566269
PMC - PMC3658236
OTO - NOTNLM
OT  - activated protein C
OT  - acute respiratory distress syndrome
OT  - septic shock
OT  - severe head injury
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2013/06/12 06:00
PHST- 2013/06/12 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - 10.2147/IMCRJ.S21249 [doi]
AID - imcrj-4-041 [pii]
PST - epublish
SO  - Int Med Case Rep J. 2011 Jun 29;4:41-6. doi: 10.2147/IMCRJ.S21249. Print 2011.


PMID- 23589992
OWN - NLM
STAT- MEDLINE
DCOM- 20130503
LR  - 20191112
IS  - 1028-7825 (Print)
IS  - 1028-7825 (Linking)
VI  - 17
IP  - 2
DP  - 2011
TI  - Unity in diversity: can there ever be a true European consensus in bioethics?
PG  - 222-34
AB  - This article, taken from a presentation to the 2011 European Association of
      Centres of Medical Ethics (EACME) annual conference, draws on both national
      legislation in European states and the Conventions of the Council of Europe as
      well as EU instruments such the Opinions of the European Group on Ethics in
      Science and New Technologies (EGE) and the Charter of Fundamental Rights to
      examine the current state of national and regional diversity in approaches to key
      bioethics issues and examines its evolution with reference to debates surrounding
      the development of key pieces of EU legislation and Council of Europe policy with
      bioethical implications. The relationship between the EU's genesis as a primarily
      economic and commercial governance entity--with its accompanying emphasis on the 
      harmonization of technical standards--and its approach to diversity in national
      bioethical perspectives is also examined. Conclusions are drawn as to the
      relative success and desirability of the European consensus process in bioethics.
FAU - Fieldsend, David
AU  - Fieldsend D
AD  - Brussels Office Manager, CARE for Europe, 205114 Rue Belliard, 1040-Brussels,
      Belgium. david.fieldsend@careforeurope.org
LA  - eng
PT  - Journal Article
PL  - England
TA  - Hum Reprod Genet Ethics
JT  - Human reproduction and genetic ethics
JID - 9815992
SB  - IM
MH  - *Beginning of Human Life
MH  - *Bioethical Issues
MH  - Bioethics/*trends
MH  - *Consensus
MH  - Cultural Diversity
MH  - *European Union
MH  - Humans
MH  - Parents
MH  - *Personhood
MH  - Quality of Life
MH  - Social Values
MH  - *Value of Life
EDAT- 2011/01/01 00:00
MHDA- 2013/05/04 06:00
CRDT- 2013/04/18 06:00
PHST- 2013/04/18 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2013/05/04 06:00 [medline]
AID - 10.1558/hrge.v17i2.222 [doi]
PST - ppublish
SO  - Hum Reprod Genet Ethics. 2011;17(2):222-34. doi: 10.1558/hrge.v17i2.222.


PMID- 23589991
OWN - NLM
STAT- MEDLINE
DCOM- 20130503
LR  - 20191112
IS  - 1028-7825 (Print)
IS  - 1028-7825 (Linking)
VI  - 17
IP  - 2
DP  - 2011
TI  - Engineering innovation in healthcare: technology, ethics and persons.
PG  - 204-21
AB  - Engineering makes profound contributions to our health. Many of these
      contributions benefit whole populations, such as clean water and sewage
      treatment, buildings, dependable sources of energy, efficient harvesting and
      storage of food, and pharmaceutical manufacture. Thus, ethical assessment of
      these and other engineering activities has often emphasized benefits to
      communities. This is in contrast to medical ethics, which has tended to emphasize
      the individual patient affected by a doctor's actions. However technological
      innovation is leading to an entanglement of the activities, and hence ethical
      responsibilities, of healthcare professionals and engineering professionals. The 
      article outlines three categories of innovation: assistive technologies,
      telehealthcare and quasi-autonomous systems. Approaches to engineering ethics are
      described and applied to these innovations. Such innovations raise a number of
      ethical opportunities and challenges, especially as the complexity of the
      technology increases. In particular the design and operation of the technologies 
      require engineers to seek closer involvement with the persons benefiting from
      their work. Future innovation will require engineers to have a good knowledge of 
      human biology and psychology. More particularly, healthcare engineers will need
      to prioritize each person's wellbeing, agency, human relationships and ecological
      self rather than technology, in the same way that doctors prioritize the
      treatment of persons rather than their diseases.
FAU - Bowen, W Richard
AU  - Bowen WR
AD  - i-NewtonWales, 54 Llwyn y mor, Caswell, Swansea SA3 4RD, UK.
      wrichardbowen@i-newtonwales.org.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - Hum Reprod Genet Ethics
JT  - Human reproduction and genetic ethics
JID - 9815992
SB  - IM
MH  - Bioethics
MH  - *Delivery of Health Care/ethics/methods/standards/trends
MH  - *Engineering/ethics/standards/trends
MH  - Ethics, Professional
MH  - Humans
MH  - *Inventions/ethics/standards/trends
MH  - *Personhood
MH  - Population Dynamics/trends
MH  - Self-Help Devices/ethics/standards/trends
MH  - *Social Responsibility
MH  - Telemedicine/ethics/standards/trends
EDAT- 2011/01/01 00:00
MHDA- 2013/05/04 06:00
CRDT- 2013/04/18 06:00
PHST- 2013/04/18 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2013/05/04 06:00 [medline]
AID - 10.1558/hrge.v17i2.204 [doi]
PST - ppublish
SO  - Hum Reprod Genet Ethics. 2011;17(2):204-21. doi: 10.1558/hrge.v17i2.204.


PMID- 23589989
OWN - NLM
STAT- MEDLINE
DCOM- 20130503
LR  - 20191112
IS  - 1028-7825 (Print)
IS  - 1028-7825 (Linking)
VI  - 17
IP  - 2
DP  - 2011
TI  - Biotechnology and human dignity: a European perspective.
PG  - 155-84
AB  - The precise meaning of "human dignity" is increasingly being questioned in ethics
      and law Is human dignity an adequate guide to policymaking in today's
      biotechnological era? This article is an attempt to answer this thorny issue. The
      emergence of the concept of human dignity as a key point of reference for the
      regulation of modern science and technology in the European Union is evaluated.
      The main contribution of this article is to prove that in EU Directives and
      Recommendations, human dignity is not an elusive concept but rather a regulatory 
      restraint in European public policies on biotechnology, particularly through the 
      influence of the European Group on Ethics in Science and New Technologies (EGE). 
      Two examples will be elaborated to prove this claim: first, the issue of
      intellectual property in biotechnological inventions, and secondly the funding of
      research proposals involving the use of human embryonic stem cells. These
      examples prove that the principle of human dignity is not an empty concept as
      some philosophers and bioethicists claim but rather a normative guideline that is
      shaping European policies on biotechnology.
FAU - Agius, Emmanuel
AU  - Agius E
AD  - Faculty of Theology, Room 204 Humanities A Building, University of Malta, Msida
      MSD 2080, Malta. emmanuel.agius@um.edu.mt
LA  - eng
PT  - Journal Article
PL  - England
TA  - Hum Reprod Genet Ethics
JT  - Human reproduction and genetic ethics
JID - 9815992
SB  - IM
MH  - *Biotechnology/economics/ethics/legislation & jurisprudence
MH  - Concept Formation
MH  - *Embryo Research/economics/ethics/legislation & jurisprudence
MH  - *European Union
MH  - Humans
MH  - *Intellectual Property
MH  - *Personhood
MH  - *Policy Making
MH  - Public Policy/*trends
MH  - *Research Support as Topic/economics/ethics/legislation & jurisprudence
MH  - *Stem Cell Research/economics/ethics/legislation & jurisprudence
EDAT- 2011/01/01 00:00
MHDA- 2013/05/04 06:00
CRDT- 2013/04/18 06:00
PHST- 2013/04/18 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2013/05/04 06:00 [medline]
AID - 10.1558/hrge.v17i2.155 [doi]
PST - ppublish
SO  - Hum Reprod Genet Ethics. 2011;17(2):155-84. doi: 10.1558/hrge.v17i2.155.


PMID- 23589988
OWN - NLM
STAT- MEDLINE
DCOM- 20130503
LR  - 20191112
IS  - 1028-7825 (Print)
IS  - 1028-7825 (Linking)
VI  - 17
IP  - 2
DP  - 2011
TI  - Bioethics and the demise of the concept of human dignity: has medicine killed
      ethics?
PG  - 141-54
AB  - The rise of "dignity talk" has led to the concept of human dignity being
      criticized in recent years. Some critics argue that human dignity must either be 
      something we have or something we acquire. Others argue that there is no such
      thing as human dignity and people really mean something else when they appeal to 
      it. Both "dignity talk" and the criticisms arise from a problematic conception of
      medical ethics as a legalistic, procedural techne. A retrieval of hermeneutical
      ethics, by contrast, offers a way to overcome both the legalism of contemporary
      ethics and the abuses and criticisms of the concept of human dignity. Such an
      ethics affirms both the inherent dignity of a human being as a multi-dimensional,
      meaning-seeking, historically-situated, relational individual, who desires to
      live a good life, and the realized sense of his/her own dignity toward which s/he
      works. As such, human dignity cannot be reduced to one feature of the human, and 
      instead functions as both a descriptive category that avoids moralism, and as a
      normative category that allows relativity whilst avoiding relativism.
FAU - Kirchhoffer, David G
AU  - Kirchhoffer DG
AD  - School of Theology, Australian Catholic University, PO Box 456, Virgina QLD, 4014
      Australia. David.Kirchhoffer@acu.edu.au
LA  - eng
PT  - Journal Article
PL  - England
TA  - Hum Reprod Genet Ethics
JT  - Human reproduction and genetic ethics
JID - 9815992
SB  - IM
MH  - *Bioethics/trends
MH  - Concept Formation
MH  - Ethical Analysis
MH  - *Ethical Theory
MH  - Ethics, Medical
MH  - Human Rights
MH  - Humans
MH  - *Moral Obligations
MH  - *Personhood
EDAT- 2011/01/01 00:00
MHDA- 2013/05/04 06:00
CRDT- 2013/04/18 06:00
PHST- 2013/04/18 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2013/05/04 06:00 [medline]
AID - 10.1558/hrge.v17i2.141 [doi]
PST - ppublish
SO  - Hum Reprod Genet Ethics. 2011;17(2):141-54. doi: 10.1558/hrge.v17i2.141.


PMID- 23580046
OWN - NLM
STAT- MEDLINE
DCOM- 20150413
LR  - 20211021
IS  - 1930-0573 (Electronic)
IS  - 1535-7414 (Linking)
VI  - 34
IP  - 1
DP  - 2011
TI  - Focus on: the use of animal models for the study of fetal alcohol spectrum
      disorders.
PG  - 92-8
AB  - Considerable efforts to educate women not to abuse alcohol during pregnancy have 
      failed to reduce the incidence of fetal alcohol syndrome. Therefore, other
      approaches to limit the effects of prenatal alcohol exposure are under
      consideration, including the development of prevention programs and
      interventions. For these strategies to be as successful as possible, it also is
      important to improve methods for identifying affected children. The use of animal
      models in prenatal alcohol exposure research is critical because of the practical
      and ethical limitations of using human subjects for such studies. This article
      reviews the use of animal models in three areas of research: addressing basic
      questions about alcohol exposure during development; improving the identification
      of affected individuals; and developing approaches to reduce the impact of
      prenatal alcohol exposure. The various animal-model systems that have been used
      to study fetal alcohol spectrum disorders, each with their own specific
      strengths, have provided new findings that have been successfully extrapolated to
      human subjects, resulting in advancement of the research field and our
      understanding of fetal alcohol spectrum disorders.
FAU - Wilson, Shannon E
AU  - Wilson SE
AD  - College of Veterinary Medicine and Biomedical Sciences, Texas A and M University,
      College Station, Texas.
FAU - Cudd, Timothy A
AU  - Cudd TA
LA  - eng
GR  - AA-017120/AA/NIAAA NIH HHS/United States
GR  - K08 AA018166/AA/NIAAA NIH HHS/United States
GR  - K08 AA018166-01A1/AA/NIAAA NIH HHS/United States
GR  - AA-10940/AA/NIAAA NIH HHS/United States
GR  - K08AA18166/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United States
TA  - Alcohol Res Health
JT  - Alcohol research & health : the journal of the National Institute on Alcohol
      Abuse and Alcoholism
JID - 100900708
SB  - IM
MH  - Alcohol Drinking/*adverse effects
MH  - Animals
MH  - *Disease Models, Animal
MH  - Female
MH  - Fetal Alcohol Spectrum Disorders/*diagnosis/etiology
MH  - Fetal Development/drug effects/physiology
MH  - Humans
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*diagnosis/etiology
PMC - PMC3625987
MID - NIHMS344187
EDAT- 2011/01/01 00:00
MHDA- 2015/04/14 06:00
CRDT- 2013/04/13 06:00
PHST- 2013/04/13 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2015/04/14 06:00 [medline]
PST - ppublish
SO  - Alcohol Res Health. 2011;34(1):92-8.


PMID- 23509672
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130320
LR  - 20211021
IS  - 2229-5070 (Print)
IS  - 2229-5070 (Linking)
VI  - 1
IP  - 1
DP  - 2011 Jan
TI  - Ethics in human research.
PG  - 2-3
LID - 10.4103/2229-5070.72105 [doi]
FAU - Mandal, Jharna
AU  - Mandal J
AD  - Department of Microbiology, Jawaharlal Institute of Postgraduate Medical
      Education and Research (JIPMER), Puducherry - 605 006, India. E-mail:
      subhashparija@yahoo.co.in.
FAU - Acharya, Srinivas
AU  - Acharya S
FAU - Parija, Subhash Chandra
AU  - Parija SC
LA  - eng
PT  - Journal Article
PL  - India
TA  - Trop Parasitol
JT  - Tropical parasitology
JID - 101580198
PMC - PMC3593469
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2013/03/20 06:00
PHST- 2013/03/20 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - 10.4103/2229-5070.72105 [doi]
AID - TP-1-2 [pii]
PST - ppublish
SO  - Trop Parasitol. 2011 Jan;1(1):2-3. doi: 10.4103/2229-5070.72105.


PMID- 23393536
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130211
LR  - 20211021
IS  - 1836-1935 (Print)
IS  - 1836-1935 (Linking)
VI  - 4
IP  - 8
DP  - 2011
TI  - To waiver or not to waiver? The dilemma of informed consent in emergency
      department suicide prevention research.
PG  - 463-8
LID - 10.4066/AMJ.2011.903 [doi]
AB  - Ethical issues are inherent in research with vulnerable populations; researchers 
      are encouraged to view these issues as challenges rather than obstacles. This
      paper details the request of a suicide prevention research collaboration to
      collect data in specific circumstances involving the waiver of consent. The
      conflicting multi-ethics committees' responses to this request are examined, with
      the purpose of highlighting the resultant impact of delayed multi-site ethical
      approvals. Implications of the committees' responses for this research in terms
      of being able to address the original stated project aims of improving future
      acute health service provision to suicidal individuals are discussed.
FAU - Hill, Nicole
AU  - Hill N
AD  - Melbourne School of Health Sciences, University of Melbourne.
FAU - Joubert, Lynette
AU  - Joubert L
FAU - Harvey, Carol
AU  - Harvey C
FAU - Hawthorne, Graeme
AU  - Hawthorne G
LA  - eng
PT  - Case Reports
DEP - 20110831
PL  - Canada
TA  - Australas Med J
JT  - The Australasian medical journal
JID - 101558564
PMC - PMC3562890
OTO - NOTNLM
OT  - Research
OT  - emergency department
OT  - ethical dilemma
OT  - self-discharge
OT  - self-harm
OT  - suicide
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2013/02/09 06:00
PHST- 2013/02/09 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - 10.4066/AMJ.2011.903 [doi]
AID - 2011903 [pii]
PST - ppublish
SO  - Australas Med J. 2011;4(8):463-8. doi: 10.4066/AMJ.2011.903. Epub 2011 Aug 31.


PMID- 23393534
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130211
LR  - 20211021
IS  - 1836-1935 (Print)
IS  - 1836-1935 (Linking)
VI  - 4
IP  - 8
DP  - 2011
TI  - Digital indiscretions: New horizons in medical ethics.
PG  - 453-6
LID - 10.4066/AMJ.2011899 [doi]
FAU - Chandra, Shivika
AU  - Chandra S
AD  - Shivika Chandra is a recent medical graduate from Kasturba Medical College
      Mangalore.
FAU - Chatterjee, Pranab
AU  - Chatterjee P
LA  - eng
PT  - Journal Article
DEP - 20110831
PL  - Canada
TA  - Australas Med J
JT  - The Australasian medical journal
JID - 101558564
PMC - PMC3562888
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2013/02/09 06:00
PHST- 2013/02/09 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - 10.4066/AMJ.2011899 [doi]
AID - 2011899 [pii]
PST - ppublish
SO  - Australas Med J. 2011;4(8):453-6. doi: 10.4066/AMJ.2011899. Epub 2011 Aug 31.


PMID- 23350220
OWN - NLM
STAT- MEDLINE
DCOM- 20130208
LR  - 20191112
IS  - 1028-7825 (Print)
IS  - 1028-7825 (Linking)
VI  - 17
IP  - 1
DP  - 2011
TI  - The ethics of commercial surrogate mothering: a response to Casey Humbyrd.
PG  - 110-21
AB  - This article critically examines the argument advanced by Casey Humbyrd in
      support of international commercial surrogate mothering. It finds her arguments
      unconvincing especially at the point of implementation. This is because the
      author was unable to demonstrate how regulation and her notion offair
      compensation would not lead to undue inducement and exploitation in resource-poor
      settings where urgent needs often exist. In fact, the argument advanced in this
      article is that commercial surrogate mothering cannot but be exploitative in so
      far as urgent and compelling needs exist. To logically drive home this point, the
      elements of exploitation were discussed in order to show that regulation and fair
      compensation cannot prevent exploitative transaction in commercial surrogate
      mothering arrangements. This may happen in the same way as regulation and
      compensation framework have not been successful in preventing the allegations of 
      exploitation in the research context especially where studies are conducted in
      resource-poor countries.
FAU - Omonzejele, Peter F
AU  - Omonzejele PF
AD  - Department of Philosophy, University of Benin, Benin-City, Edo State, Nigeria.
      pomonzejele@yahoo.com
LA  - eng
PT  - Journal Article
PL  - England
TA  - Hum Reprod Genet Ethics
JT  - Human reproduction and genetic ethics
JID - 9815992
SB  - IM
MH  - *Coercion
MH  - Commerce/*ethics
MH  - Female
MH  - *Freedom
MH  - Humans
MH  - Informed Consent
MH  - *Personal Autonomy
MH  - *Poverty
MH  - Pregnancy
MH  - *Surrogate Mothers
MH  - Women's Rights
EDAT- 2011/01/01 00:00
MHDA- 2013/02/09 06:00
CRDT- 2013/01/29 06:00
PHST- 2013/01/29 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2013/02/09 06:00 [medline]
AID - 10.1558/hrge.v17i1.110 [doi]
PST - ppublish
SO  - Hum Reprod Genet Ethics. 2011;17(1):110-21. doi: 10.1558/hrge.v17i1.110.


PMID- 23350217
OWN - NLM
STAT- MEDLINE
DCOM- 20130208
LR  - 20191112
IS  - 1028-7825 (Print)
IS  - 1028-7825 (Linking)
VI  - 17
IP  - 1
DP  - 2011
TI  - Believing in the dignity of human embryos.
PG  - 53-65
AB  - After showing that despite being inherently flawed the concept of dignity cannot 
      be replaced without loss by ethical principles such as "respect for persons," it 
      is argued that, if dignity be not understood as dignitas, but as bonitas, which
      emphasizes connectedness rather than excellence and to which the proper response 
      is not respect, but awe, there is no reason not to ascribe it to the human
      embryo. The question whether or not human embryos have dignity can then be
      answered in the affirmative on the same pragmatist grounds that ultimately lead
      us to respect other human persons as possessors of dignity, that is, a special
      moral worth.
FAU - Hauskeller, Michael
AU  - Hauskeller M
AD  - Sociology and Philosophy, University of Exeter, Amory Building, Rennes Drive,
      Exeter, EX4 4RJ, UK. M.Hauskeller@exeter.ac.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - Hum Reprod Genet Ethics
JT  - Human reproduction and genetic ethics
JID - 9815992
SB  - IM
MH  - *Emotions/ethics
MH  - *Human Characteristics
MH  - Humans
MH  - *Moral Obligations
MH  - Morals
MH  - *Personhood
MH  - Value of Life
EDAT- 2011/01/01 00:00
MHDA- 2013/02/09 06:00
CRDT- 2013/01/29 06:00
PHST- 2013/01/29 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2013/02/09 06:00 [medline]
AID - 10.1558/hrge.v17i1.53 [doi]
PST - ppublish
SO  - Hum Reprod Genet Ethics. 2011;17(1):53-65. doi: 10.1558/hrge.v17i1.53.


PMID- 23350215
OWN - NLM
STAT- MEDLINE
DCOM- 20130208
LR  - 20191112
IS  - 1028-7825 (Print)
IS  - 1028-7825 (Linking)
VI  - 17
IP  - 1
DP  - 2011
TI  - Embryo research in Italy: the bioethical and biojuridical debate.
PG  - 28-39
AB  - This article deals with the discussion on the status of the human embryo in Italy
      on a philosophical, socio-ethical and juridical level before, during and after
      the law (n. 40/2004). Different lines of thought are outlined and critically
      discussed. The focus is the debate over the so-called embryonic stem cells,
      pointing out the ethical premises and the juridical implications. The regulations
      in Italy are analysed in detail, referring to legislation and jurisprudence
      (showing analogies and differences). In particular the author includes evidence
      for the debate after the law came in, with specific attention on the question of 
      the use of imported embryonic stem cells and public financing for research and
      the problem of the use of frozen and non-implantable embryos.
FAU - Palazzani, Laura
AU  - Palazzani L
AD  - Lumsa University, via Pompeo Magno 22, 00192 Roma, Italy. palazzani@lumsa.it
LA  - eng
PT  - Journal Article
PL  - England
TA  - Hum Reprod Genet Ethics
JT  - Human reproduction and genetic ethics
JID - 9815992
SB  - IM
MH  - Blastomeres
MH  - Cryopreservation
MH  - Embryo Research/economics/*ethics/*legislation & jurisprudence
MH  - Embryo, Mammalian
MH  - *Ethics, Research
MH  - Financing, Government
MH  - Humans
MH  - Italy
MH  - Moral Obligations
MH  - *Morals
MH  - Personhood
MH  - Reproductive Techniques, Assisted
MH  - Stem Cell Research/economics/*ethics/*legislation & jurisprudence
MH  - Tissue and Organ Procurement/ethics/legislation & jurisprudence
EDAT- 2011/01/01 00:00
MHDA- 2013/02/09 06:00
CRDT- 2013/01/29 06:00
PHST- 2013/01/29 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2013/02/09 06:00 [medline]
AID - 10.1558/hrge.v17i1.28 [doi]
PST - ppublish
SO  - Hum Reprod Genet Ethics. 2011;17(1):28-39. doi: 10.1558/hrge.v17i1.28.


PMID- 23350213
OWN - NLM
STAT- MEDLINE
DCOM- 20130208
LR  - 20191112
IS  - 1028-7825 (Print)
IS  - 1028-7825 (Linking)
VI  - 17
IP  - 1
DP  - 2011
TI  - New editor of Human Reproduction and Genetic Ethics.
PG  - 5-6
FAU - Stammers, Trevor
AU  - Stammers T
LA  - eng
PT  - Editorial
PT  - Introductory Journal Article
PL  - England
TA  - Hum Reprod Genet Ethics
JT  - Human reproduction and genetic ethics
JID - 9815992
SB  - IM
MH  - Congresses as Topic
MH  - Embryo Research/*ethics/*legislation & jurisprudence
MH  - *Embryo, Mammalian
MH  - Ethics, Medical
MH  - Ethics, Research
MH  - Genetic Research/*ethics/*legislation & jurisprudence
MH  - Humans
MH  - Ireland
MH  - Italy
MH  - Reproduction
MH  - United Kingdom
MH  - United States
EDAT- 2011/01/01 00:00
MHDA- 2013/02/09 06:00
CRDT- 2013/01/29 06:00
PHST- 2013/01/29 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2013/02/09 06:00 [medline]
AID - 10.1558/hrge.v17i1.5 [doi]
PST - ppublish
SO  - Hum Reprod Genet Ethics. 2011;17(1):5-6. doi: 10.1558/hrge.v17i1.5.


PMID- 23264997
OWN - NLM
STAT- MEDLINE
DCOM- 20130116
LR  - 20211203
IS  - 1556-8539 (Print)
IS  - 1556-8539 (Linking)
VI  - 6
IP  - 3
DP  - 2011
TI  - Generation of clinically relevant "induced pluripotent stem" (iPS) cells.
PG  - 109-27
AB  - Proviral expression of early development genes Oct4 and Sox2, in concert with
      cMyc and Klf4 or Nanog and Lin28, can induce differentiated cells to adopt
      morphological and functional characteristics of pluripotency indistinguishable
      from embryonic stem cells. Termed induced pluripotent stem (iPS) cells, in mice
      the pluripotency of these cells was confirmed by altered gene/surface antigen
      expression, remodeling of the epigenome, ability to contribute to embryonic
      lineages following blastocyst injection and commitment to all three germ layers
      in teratomas and liveborn chimeras. Importantly, in vitro directed
      differentiation of iPS cells yield cells capable of treating mouse models of
      humanized disease. Despite these impressive results, iPS cell conversion is
      frustratingly inefficient. Also, the unpredictable and random mutagenesis imposed
      on the host cell genome, inherent with integrative viral methodologies, continues
      to hamper use of these cells in a therapeutic setting. This has initiated
      exploration of non-integrating strategies for generating iPS cells. Here, we
      review mechanisms that drive conversion of somatic cells to iPS cells and the
      strategies adopted to circumvent integrative viral strategies. Finally, we
      discuss practical, ethical and legal considerations that require addressing
      before iPS cells can realize their potential as patient-specific cells for
      treatment of degenerative disease.
FAU - Heffernan, Corey
AU  - Heffernan C
AD  - Reprogramming and Stem Cell Laboratory, Monash Institute of Medical Research,
      Monash University, Clayton, VIC, Australia.
FAU - Sumer, Huseyin
AU  - Sumer H
FAU - Verma, Paul J
AU  - Verma PJ
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Stem Cells
JT  - Journal of stem cells
JID - 101295936
RN  - 0 (Homeodomain Proteins)
RN  - 0 (KLF4 protein, human)
RN  - 0 (Klf4 protein, mouse)
RN  - 0 (Kruppel-Like Factor 4)
RN  - 0 (Kruppel-Like Transcription Factors)
RN  - 0 (Octamer Transcription Factor-3)
RN  - 0 (Proto-Oncogene Proteins c-myc)
RN  - 0 (RNA-Binding Proteins)
RN  - 0 (SOXB1 Transcription Factors)
SB  - IM
MH  - Animals
MH  - Cell Differentiation
MH  - Cells, Cultured
MH  - Cellular Reprogramming
MH  - Gene Expression Regulation, Developmental
MH  - Genetic Vectors
MH  - Genotype
MH  - Homeodomain Proteins/genetics/metabolism
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*physiology/transplantation
MH  - Kruppel-Like Factor 4
MH  - Kruppel-Like Transcription Factors/genetics/metabolism
MH  - Octamer Transcription Factor-3/genetics/metabolism
MH  - Phenotype
MH  - Proto-Oncogene Proteins c-myc/genetics/metabolism
MH  - RNA-Binding Proteins/genetics/metabolism
MH  - SOXB1 Transcription Factors/genetics/metabolism
MH  - Stem Cell Transplantation/adverse effects/ethics
MH  - Transfection
EDAT- 2011/01/01 00:00
MHDA- 2013/01/17 06:00
CRDT- 2012/12/26 06:00
PHST- 2012/12/26 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2013/01/17 06:00 [medline]
PST - ppublish
SO  - J Stem Cells. 2011;6(3):109-27.


PMID- 23259152
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 2150-7716 (Print)
IS  - 2150-7724 (Linking)
VI  - 2
IP  - 4
DP  - 2011 Jan 1
TI  - Ethics in Psychiatric Research: A Review of 25 Years of NIH-funded Empirical
      Research Projects.
PG  - 5-17
AB  - BACKGROUND: This paper reviews the past 25 years of empirical research funded by 
      the National Institutes of Health (NIH) on matters of ethics in psychiatric
      research. METHODS: Using the NIH RePORTER and Medline databases, we identified 43
      grants and 77 publications that involved the empirical study of a matter of
      ethics in research involving mental health service users. RESULTS: These articles
      provide original and useful information on important topics, most especially the 
      capacity to consent and the voluntariness of consent. For example, participants
      who share a diagnosis vary widely in levels of cognitive impairment that
      correlate with decisional capacity, and capacity to consent can be enhanced
      easily using iterative consent processes. Few articles address matters of justice
      or benefits in research, particularly from the perspectives of participants. No
      articles address matters of privacy, confidentiality, or researcher
      professionalism. CONCLUSIONS: Despite the usefulness of data from the studies
      conducted to date, current research on research ethics in psychiatry does not
      adequately address the concerns of service users as expressed in recent
      publications.
FAU - Dubois, James
AU  - Dubois J
AD  - Saint Louis University - Gnaegi Center for Health Care Ethics, 221 North Grand
      Blvd, St. Louis, Missouri 63103, duboisjm@slu.edu.
FAU - Bante, Holly
AU  - Bante H
FAU - Hadley, Whitney B
AU  - Hadley WB
LA  - eng
GR  - R13 MH079690/MH/NIMH NIH HHS/United States
GR  - UL1 RR024992/RR/NCRR NIH HHS/United States
PT  - Journal Article
DEP - 20111206
PL  - United States
TA  - AJOB Prim Res
JT  - AJOB primary research
JID - 101520734
PMC - PMC3524581
MID - NIHMS411837
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2012/12/22 06:00
PHST- 2012/12/22 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - 10.1080/21507716.2011.631514 [doi]
PST - ppublish
SO  - AJOB Prim Res. 2011 Jan 1;2(4):5-17. doi: 10.1080/21507716.2011.631514. Epub 2011
      Dec 6.


PMID- 23213865
OWN - NLM
STAT- MEDLINE
DCOM- 20130205
LR  - 20121207
IS  - 0025-8431 (Print)
IS  - 0025-8431 (Linking)
VI  - 46
IP  - 3-4
DP  - 2011
TI  - [The "good doctor". Physicians' morality and the self-conception of medicine
      since the early modern period].
PG  - 171-211
AB  - The article examines the historical change in medical ethics since the beginning 
      of the early modern period, drawing on normative sources, mostly of German
      origin. The theoretical frame of reference is provided by historical moral
      sociology and the history of the modernisation, as expounded in Niklas Luhmann's 
      system theory. In a first step, evidence for the change in the moral codes of the
      various social systems (science, economy etc.) of the early modern period is
      assembled (1) in order to approach the question, taking the medieval medical
      doctrines of salvation as a starting point (2), whether structurally analogous
      processes of change can be made out in the medical system. These are identified
      in the removal of a moral evaluation of disease and in the moral neutralization
      of doctors' behaviour which is reflected in the spread of medical happiness
      doctrines (3). Following an interim reflection on moral theory (4), the
      enforcement of a modern behavioural code in 19th-century medical deontology is
      outlined, which was based on moral restraint (5) and the specific professional
      identity of the doctor (6). A summary of the results leads to a concluding
      outlook on current trends in medical ethics discourse (7).
FAU - Polianski, Igor J
AU  - Polianski IJ
AD  - Institut fur Geschichte, Theorie und Ethik der Medizin, Univesitat Ulm, Ulm.
      igor.polianski@uni-ulm.de
LA  - ger
PT  - English Abstract
PT  - Historical Article
PT  - Journal Article
TT  - Der "gute Arzt". Arztlicher Moralhaushalt und das Selbstverstandnis der Medizin
      seit der Fruhen Neuzeit.
PL  - Germany
TA  - Medizinhist J
JT  - Medizinhistorisches Journal
JID - 0051574
SB  - IM
MH  - Ethics, Medical/*history
MH  - Europe
MH  - Germany
MH  - History, 16th Century
MH  - History, 17th Century
MH  - History, 18th Century
MH  - History, 19th Century
MH  - Humans
MH  - *Morals
MH  - Philosophy, Medical/*history
MH  - Physician's Role/*history
MH  - *Self Concept
MH  - Social Change/*history
EDAT- 2011/01/01 00:00
MHDA- 2013/02/06 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2013/02/06 06:00 [medline]
PST - ppublish
SO  - Medizinhist J. 2011;46(3-4):171-211.


PMID- 23204881
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130704
LR  - 20211021
IS  - 1918-1507 (Electronic)
IS  - 1195-2199 (Linking)
VI  - 19
IP  - 4
DP  - 2011 Winter
TI  - The opportunities and obstacles in developing a vascular birthmark database for
      clinical and research use.
PG  - 122-4
AB  - INTRODUCTION: Databases are useful tools in clinical settings. The authors review
      the benefits and challenges associated with the development and implementation of
      an efficient electronic database for the multidisciplinary Vascular Birthmark
      Clinic at the Alberta Children's Hospital, Calgary, Alberta. METHODS: The content
      and structure of the database were designed using the technical expertise of a
      data analyst from the Calgary Health Region. Relevant clinical and demographic
      data fields were included with the goal of documenting ongoing care of individual
      patients, and facilitating future epidemiological studies of this patient
      population. After completion of this database, 10 challenges encountered during
      development were retrospectively identified. Practical solutions for these
      challenges are presented. RESULTS: THE CHALLENGES IDENTIFIED DURING THE DATABASE 
      DEVELOPMENT PROCESS INCLUDED: identification of relevant data fields; balancing
      simplicity and user-friendliness with complexity and comprehensive data storage; 
      database expertise versus clinical expertise; software platform selection;
      linkage of data from the previous spreadsheet to a new data management system;
      ethics approval for the development of the database and its utilization for
      research studies; ensuring privacy and limited access to the database;
      integration of digital photographs into the database; adoption of the database by
      support staff in the clinic; and maintaining up-to-date entries in the database. 
      CONCLUSIONS: There are several challenges involved in the development of a useful
      and efficient clinical database. Awareness of these potential obstacles, in
      advance, may simplify the development of clinical databases by others in various 
      surgical settings.
FAU - Sharma, Vishal K
AU  - Sharma VK
AD  - Division of Plastic Surgery, Postgraduate Medical Education, University of
      Calgary, Calgary, Alberta.
FAU - Fraulin, Frankie Og
AU  - Fraulin FO
FAU - Harrop, A Robertson
AU  - Harrop AR
FAU - McPhalen, Donald F
AU  - McPhalen DF
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can J Plast Surg
JT  - The Canadian journal of plastic surgery = Journal canadien de chirurgie plastique
JID - 9434932
PMC - PMC3269200
OTO - NOTNLM
OT  - Database
OT  - Development
OT  - Epidemiological studies
OT  - Vascular birthmark
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2012/12/04 06:00
PHST- 2012/12/04 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
PST - ppublish
SO  - Can J Plast Surg. 2011 Winter;19(4):122-4.


PMID- 23137889
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130103
LR  - 20121109
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 13
IP  - 10
DP  - 2011 Oct 1
TI  - American medical association code of medical ethics' opinions on physicians'
      health and conduct.
PG  - 700-2
LID - 10.1001/virtualmentor.2011.13.10.coet1-1110 [doi]
LID - virtualmentor.2011.13.10.coet1-1110 [pii]
LA  - eng
PT  - Journal Article
DEP - 20111001
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2012/11/10 06:00
PHST- 2012/11/10 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - virtualmentor.2011.13.10.coet1-1110 [pii]
AID - 10.1001/virtualmentor.2011.13.10.coet1-1110 [doi]
PST - epublish
SO  - Virtual Mentor. 2011 Oct 1;13(10):700-2. doi:
      10.1001/virtualmentor.2011.13.10.coet1-1110.


PMID- 23137475
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130103
LR  - 20121109
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 13
IP  - 9
DP  - 2011 Sep 1
TI  - The AMA Code of Medical Ethics' Opinions on Patient Safety.
PG  - 626-8
LID - 10.1001/virtualmentor.2011.13.9.coet1-1109 [doi]
LID - virtualmentor.2011.13.9.coet1-1109 [pii]
LA  - eng
PT  - Journal Article
DEP - 20110901
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2012/11/10 06:00
PHST- 2012/11/10 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - virtualmentor.2011.13.9.coet1-1109 [pii]
AID - 10.1001/virtualmentor.2011.13.9.coet1-1109 [doi]
PST - epublish
SO  - Virtual Mentor. 2011 Sep 1;13(9):626-8. doi:
      10.1001/virtualmentor.2011.13.9.coet1-1109.


PMID- 23137473
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130103
LR  - 20121109
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 13
IP  - 9
DP  - 2011 Sep 1
TI  - Medical ethics and retail clinics.
PG  - 612-9
LID - 10.1001/virtualmentor.2011.13.9.bndr1-1109 [doi]
LID - virtualmentor.2011.13.9.bndr1-1109 [pii]
FAU - Heyne, Thomas
AU  - Heyne T
AD  - Medical school at the University of Texas Southwestern in Dallas.
LA  - eng
PT  - Journal Article
DEP - 20110901
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2012/11/10 06:00
PHST- 2012/11/10 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - virtualmentor.2011.13.9.bndr1-1109 [pii]
AID - 10.1001/virtualmentor.2011.13.9.bndr1-1109 [doi]
PST - epublish
SO  - Virtual Mentor. 2011 Sep 1;13(9):612-9. doi:
      10.1001/virtualmentor.2011.13.9.bndr1-1109.


PMID- 23137456
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130103
LR  - 20121109
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 13
IP  - 8
DP  - 2011 Aug 1
TI  - The AMA Code of Medical Ethics' Opinion on Physicians' Duty to the Poor.
PG  - 550
LID - 10.1001/virtualmentor.2011.13.8.coet1-1108 [doi]
LID - virtualmentor.2011.13.8.coet1-1108 [pii]
LA  - eng
PT  - Journal Article
DEP - 20110801
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2012/11/10 06:00
PHST- 2012/11/10 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - virtualmentor.2011.13.8.coet1-1108 [pii]
AID - 10.1001/virtualmentor.2011.13.8.coet1-1108 [doi]
PST - epublish
SO  - Virtual Mentor. 2011 Aug 1;13(8):550. doi:
      10.1001/virtualmentor.2011.13.8.coet1-1108.


PMID- 23137424
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130103
LR  - 20121109
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 13
IP  - 12
DP  - 2011 Dec 1
TI  - Ethical issues in the early diagnosis of Alzheimer disease.
PG  - 868-72
LID - 10.1001/virtualmentor.2011.13.12.jdsc1-1112 [doi]
LID - virtualmentor.2011.13.12.jdsc1-1112 [pii]
FAU - Growdon, Matthew E
AU  - Growdon ME
AD  - Harvard Medical School in Boston and UCSF Memory and Aging Center in San
      Francisco.
LA  - eng
PT  - Journal Article
DEP - 20111201
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2012/11/10 06:00
PHST- 2012/11/10 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - virtualmentor.2011.13.12.jdsc1-1112 [pii]
AID - 10.1001/virtualmentor.2011.13.12.jdsc1-1112 [doi]
PST - epublish
SO  - Virtual Mentor. 2011 Dec 1;13(12):868-72. doi:
      10.1001/virtualmentor.2011.13.12.jdsc1-1112.


PMID- 23137423
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130103
LR  - 20121109
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 13
IP  - 12
DP  - 2011 Dec 1
TI  - The american medical association code of medical ethics' opinions on disclosing
      diagnoses to patients.
PG  - 866-7
LID - 10.1001/virtualmentor.2011.13.12.coet1-1112 [doi]
LID - virtualmentor.2011.13.12.coet1-1112 [pii]
LA  - eng
PT  - Journal Article
DEP - 20111201
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2012/11/10 06:00
PHST- 2012/11/10 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - virtualmentor.2011.13.12.coet1-1112 [pii]
AID - 10.1001/virtualmentor.2011.13.12.coet1-1112 [doi]
PST - epublish
SO  - Virtual Mentor. 2011 Dec 1;13(12):866-7. doi:
      10.1001/virtualmentor.2011.13.12.coet1-1112.


PMID- 23137422
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130103
LR  - 20121109
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 13
IP  - 12
DP  - 2011 Dec 1
TI  - A virtue ethics approach to framing troublesome diagnoses.
PG  - 861-5
LID - 10.1001/virtualmentor.2011.13.12.ccas3-1112 [doi]
LID - virtualmentor.2011.13.12.ccas3-1112 [pii]
FAU - Geppert, Cynthia
AU  - Geppert C
AD  - New Mexico Veteran's Affairs Health Care System and associate professor of
      psychiatry and director of ethics education at the University of New Mexico in
      Albuquerque.
LA  - eng
PT  - Journal Article
DEP - 20111201
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2012/11/10 06:00
PHST- 2012/11/10 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - virtualmentor.2011.13.12.ccas3-1112 [pii]
AID - 10.1001/virtualmentor.2011.13.12.ccas3-1112 [doi]
PST - epublish
SO  - Virtual Mentor. 2011 Dec 1;13(12):861-5. doi:
      10.1001/virtualmentor.2011.13.12.ccas3-1112.


PMID- 23137363
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130103
LR  - 20121109
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 13
IP  - 11
DP  - 2011 Nov 1
TI  - The American Medical Association Code of Medical Ethics' Opinion on
      Pay-for-Performance Programs and Patients' Interests.
PG  - 775-6
LID - 10.1001/virtualmentor.2011.13.11.coet1-1111 [doi]
LID - virtualmentor.2011.13.11.coet1-1111 [pii]
LA  - eng
PT  - Journal Article
DEP - 20111101
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2012/11/10 06:00
PHST- 2012/11/10 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - virtualmentor.2011.13.11.coet1-1111 [pii]
AID - 10.1001/virtualmentor.2011.13.11.coet1-1111 [doi]
PST - epublish
SO  - Virtual Mentor. 2011 Nov 1;13(11):775-6. doi:
      10.1001/virtualmentor.2011.13.11.coet1-1111.


PMID- 23134800
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130103
LR  - 20121108
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 13
IP  - 7
DP  - 2011 Jul 1
TI  - A delicate balance-ethical standards for physician-journalists.
PG  - 490-3
LID - 10.1001/virtualmentor.2011.13.7.pfor1-1107 [doi]
LID - virtualmentor.2011.13.7.pfor1-1107 [pii]
FAU - Linden, Tom
AU  - Linden T
AD  - Medical and Science Journalism Program at the School of Journalism and Mass
      Communication at the University of North Carolina at Chapel Hill.
LA  - eng
PT  - Journal Article
DEP - 20110701
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2012/11/09 06:00
PHST- 2012/11/09 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - virtualmentor.2011.13.7.pfor1-1107 [pii]
AID - 10.1001/virtualmentor.2011.13.7.pfor1-1107 [doi]
PST - epublish
SO  - Virtual Mentor. 2011 Jul 1;13(7):490-3. doi:
      10.1001/virtualmentor.2011.13.7.pfor1-1107.


PMID- 23134796
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130103
LR  - 20220318
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 13
IP  - 7
DP  - 2011 Jul 1
TI  - The AMA Code of Medical Ethics' Opinions on Confidentiality of Patient
      Information.
PG  - 475-7
LID - 10.1001/virtualmentor.2011.13.7.coet1-1107 [doi]
LID - virtualmentor.2011.13.7.coet1-1107 [pii]
LA  - eng
PT  - Journal Article
DEP - 20110701
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2012/11/09 06:00
PHST- 2012/11/09 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - virtualmentor.2011.13.7.coet1-1107 [pii]
AID - 10.1001/virtualmentor.2011.13.7.coet1-1107 [doi]
PST - epublish
SO  - Virtual Mentor. 2011 Jul 1;13(7):475-7. doi:
      10.1001/virtualmentor.2011.13.7.coet1-1107.


PMID- 23134793
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130103
LR  - 20121108
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 13
IP  - 7
DP  - 2011 Jul 1
TI  - 2010 Runner-Up Essay:Jason's Journal-Thoughts of an Ethically Conflicted Medical 
      Student.
PG  - 461-5
LID - 10.1001/virtualmentor.2011.13.7.conl3-1107 [doi]
LID - virtualmentor.2011.13.7.conl3-1107 [pii]
FAU - Shah, Ankoor
AU  - Shah A
AD  - Emory University School of Medicine in Atlanta, Emory's Rollins School of Public 
      Health.
LA  - eng
PT  - Journal Article
DEP - 20110701
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2012/11/09 06:00
PHST- 2012/11/09 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - virtualmentor.2011.13.7.conl3-1107 [pii]
AID - 10.1001/virtualmentor.2011.13.7.conl3-1107 [doi]
PST - epublish
SO  - Virtual Mentor. 2011 Jul 1;13(7):461-5. doi:
      10.1001/virtualmentor.2011.13.7.conl3-1107.


PMID- 23134789
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130103
LR  - 20121108
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 13
IP  - 7
DP  - 2011 Jul 1
TI  - Ethics, memoir, and medicine.
PG  - 435-9
LID - 10.1001/virtualmentor.2011.13.7.ccas2-1107 [doi]
LID - virtualmentor.2011.13.7.ccas2-1107 [pii]
FAU - Coulehan, Jack
AU  - Coulehan J
AD  - Center for Medical Humanities, Compassionate Care, and Bioethics at Stony Brook
      University in New York.
LA  - eng
PT  - Journal Article
DEP - 20110701
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2012/11/09 06:00
PHST- 2012/11/09 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - virtualmentor.2011.13.7.ccas2-1107 [pii]
AID - 10.1001/virtualmentor.2011.13.7.ccas2-1107 [doi]
PST - epublish
SO  - Virtual Mentor. 2011 Jul 1;13(7):435-9. doi:
      10.1001/virtualmentor.2011.13.7.ccas2-1107.


PMID- 23134787
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130103
LR  - 20121108
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 13
IP  - 7
DP  - 2011 Jul 1
TI  - Healing Narrative-Ethics and Writing about Patients.
PG  - 420-4
LID - 10.1001/virtualmentor.2011.13.7.fred1-1107 [doi]
LID - virtualmentor.2011.13.7.fred1-1107 [pii]
FAU - Osipov, Rimma
AU  - Osipov R
AD  - Institute for the Medical Humanities University of Texas Medical Branch in
      Galveston.
LA  - eng
PT  - Journal Article
DEP - 20110701
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2012/11/09 06:00
PHST- 2012/11/09 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - virtualmentor.2011.13.7.fred1-1107 [pii]
AID - 10.1001/virtualmentor.2011.13.7.fred1-1107 [doi]
PST - epublish
SO  - Virtual Mentor. 2011 Jul 1;13(7):420-4. doi:
      10.1001/virtualmentor.2011.13.7.fred1-1107.


PMID- 23131402
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130103
LR  - 20121107
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 13
IP  - 6
DP  - 2011 Jun 1
TI  - AMA Code of Medical Ethics' Opinions on Ethical Referral.
PG  - 359-60
LID - 10.1001/virtualmentor.2011.13.6.coet1-1106 [doi]
LID - virtualmentor.2011.13.6.coet1-1106 [pii]
LA  - eng
PT  - Journal Article
DEP - 20110601
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2012/11/08 06:00
PHST- 2012/11/08 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - virtualmentor.2011.13.6.coet1-1106 [pii]
AID - 10.1001/virtualmentor.2011.13.6.coet1-1106 [doi]
PST - epublish
SO  - Virtual Mentor. 2011 Jun 1;13(6):359-60. doi:
      10.1001/virtualmentor.2011.13.6.coet1-1106.


PMID- 23131361
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130102
LR  - 20121107
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 13
IP  - 5
DP  - 2011 May 1
TI  - Ethical and regulatory considerations in prescribing RU-486.
PG  - 299-303
LID - 10.1001/virtualmentor.2011.13.5.hlaw1-1105 [doi]
LID - virtualmentor.2011.13.5.hlaw1-1105 [pii]
FAU - Parrish, Alyssa
AU  - Parrish A
AD  - Texas Tech University School of Law.
LA  - eng
PT  - Journal Article
DEP - 20110501
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2012/11/08 06:00
PHST- 2012/11/08 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - virtualmentor.2011.13.5.hlaw1-1105 [pii]
AID - 10.1001/virtualmentor.2011.13.5.hlaw1-1105 [doi]
PST - epublish
SO  - Virtual Mentor. 2011 May 1;13(5):299-303. doi:
      10.1001/virtualmentor.2011.13.5.hlaw1-1105.


PMID- 23131359
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130102
LR  - 20121107
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 13
IP  - 5
DP  - 2011 May 1
TI  - Recognizing and resolving ethical dilemmas in rural medicine.
PG  - 291-4
LID - 10.1001/virtualmentor.2011.13.5.jdsc1-1105 [doi]
LID - virtualmentor.2011.13.5.jdsc1-1105 [pii]
FAU - Shih, Tiffany L
AU  - Shih TL
AD  - Texas Tech University Health Sciences Center, Midland, TX, USA.
FAU - Goldman, Joshua J
AU  - Goldman JJ
LA  - eng
PT  - Comment
PT  - Journal Article
DEP - 20110501
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
CON - Am J Bioeth. 2008 Apr;8(4):52-6. PMID: 18576259
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2012/11/08 06:00
PHST- 2012/11/08 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - virtualmentor.2011.13.5.jdsc1-1105 [pii]
AID - 10.1001/virtualmentor.2011.13.5.jdsc1-1105 [doi]
PST - epublish
SO  - Virtual Mentor. 2011 May 1;13(5):291-4. doi:
      10.1001/virtualmentor.2011.13.5.jdsc1-1105.


PMID- 23131328
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130102
LR  - 20121107
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 13
IP  - 4
DP  - 2011 Apr 1
TI  - AMA Code of Medical Ethics' opinions on allocating medical resources.
PG  - 228-9
LID - 10.1001/virtualmentor.2011.13.4.coet1-1104 [doi]
LID - virtualmentor.2011.13.4.coet1-1104 [pii]
LA  - eng
PT  - Journal Article
DEP - 20110401
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2012/11/08 06:00
PHST- 2012/11/08 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - virtualmentor.2011.13.4.coet1-1104 [pii]
AID - 10.1001/virtualmentor.2011.13.4.coet1-1104 [doi]
PST - epublish
SO  - Virtual Mentor. 2011 Apr 1;13(4):228-9. doi:
      10.1001/virtualmentor.2011.13.4.coet1-1104.


PMID- 23127321
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130102
LR  - 20121106
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 13
IP  - 3
DP  - 2011 Mar 1
TI  - Ethical dimensions of meaningful use requirements for electronic health records.
PG  - 176-80
LID - 10.1001/virtualmentor.2011.13.3.pfor1-1103 [doi]
LID - virtualmentor.2011.13.3.pfor1-1103 [pii]
FAU - Miller, Stephen T
AU  - Miller ST
AD  - University of Tennessee Health Science Center, Memphis, Tennessee, USA.
FAU - MacGregor, Alastair
AU  - MacGregor A
LA  - eng
GR  - 1 R01 AG033005/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110301
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2012/11/07 06:00
PHST- 2012/11/07 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - virtualmentor.2011.13.3.pfor1-1103 [pii]
AID - 10.1001/virtualmentor.2011.13.3.pfor1-1103 [doi]
PST - epublish
SO  - Virtual Mentor. 2011 Mar 1;13(3):176-80. doi:
      10.1001/virtualmentor.2011.13.3.pfor1-1103.


PMID- 23121847
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130102
LR  - 20121105
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 13
IP  - 2
DP  - 2011 Feb 1
TI  - The AMA Code of Medical Ethics' opinion on population-based genomic research.
PG  - 100-1
LID - 10.1001/virtualmentor.2011.13.2.coet1-1102 [doi]
LID - virtualmentor.2011.13.2.coet1-1102 [pii]
LA  - eng
PT  - Journal Article
DEP - 20110201
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2012/11/06 06:00
PHST- 2012/11/06 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - virtualmentor.2011.13.2.coet1-1102 [pii]
AID - 10.1001/virtualmentor.2011.13.2.coet1-1102 [doi]
PST - epublish
SO  - Virtual Mentor. 2011 Feb 1;13(2):100-1. doi:
      10.1001/virtualmentor.2011.13.2.coet1-1102.


PMID- 23121812
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130102
LR  - 20121105
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 13
IP  - 1
DP  - 2011 Jan 1
TI  - The AMA Code of Medical Ethics' opinion on physician pay-for-performance
      programs.
PG  - 25
LID - 10.1001/virtualmentor.2011.13.1.coet1-1101 [doi]
LID - virtualmentor.2011.13.1.coet1-1101 [pii]
LA  - eng
PT  - Journal Article
DEP - 20110101
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2012/11/06 06:00
PHST- 2012/11/06 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - virtualmentor.2011.13.1.coet1-1101 [pii]
AID - 10.1001/virtualmentor.2011.13.1.coet1-1101 [doi]
PST - epublish
SO  - Virtual Mentor. 2011 Jan 1;13(1):25. doi:
      10.1001/virtualmentor.2011.13.1.coet1-1101.


PMID- 23113090
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121101
LR  - 20220317
IS  - 2251-6085 (Print)
IS  - 2251-6085 (Linking)
VI  - 40
IP  - 3
DP  - 2011
TI  - Assessing a group of physicians' ethical sensitivity in Turkey.
PG  - 89-97
AB  - BACKGROUND: The objective was to measure the sensitivity of a group of physicians
      regarding the ethics-related situations, which they faced during patient care and
      treatment. METHODS: All of 306 physicians who joined the Turkish Army for
      compulsory military service in December 2008 were included in the study. A "Moral
      Sensitivity Questionnaire", formed by Kim Lutzen, was applied to all of them.
      RESULTS: From total, 95% of physicians performed their job willingly, 88% of
      physicians attended ethic lessons (n=265), 72.4% (n=218) followed ethic
      publications, 67.4% (n=203) stated that there was an ethic committee at their
      institutions, and 5% worked as a member of the ethic committee. There were
      statistically significant differences between autonomy, benevolence meaning,
      conflict, and total scores according to workplace of physicians, employment
      period, and being specialists. Points of autonomy were found lower in physicians 
      working at private hospital and health center than those at public hospital.
      CONCLUSION: Ethical sensitivity of physicians changed due to work place. We
      conclude that organizational arrangements are of beneficial effects to increase
      ethical sensitivity.
FAU - Cetin, M
AU  - Cetin M
AD  - Gulhane Military Medical Academy, Dept. of Military Health Services, 06018
      Etlik/Ankara, Turkey.
FAU - Cimen, M
AU  - Cimen M
LA  - eng
PT  - Journal Article
DEP - 20110930
PL  - Iran
TA  - Iran J Public Health
JT  - Iranian journal of public health
JID - 7505531
PMC - PMC3481639
OTO - NOTNLM
OT  - Ethical Sensitivity
OT  - Healthcare Services
OT  - Physician
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2012/11/01 06:00
PHST- 2011/03/06 00:00 [received]
PHST- 2011/07/14 00:00 [accepted]
PHST- 2012/11/01 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
PST - ppublish
SO  - Iran J Public Health. 2011;40(3):89-97. Epub 2011 Sep 30.


PMID- 23057204
OWN - NLM
STAT- MEDLINE
DCOM- 20121120
LR  - 20170330
IS  - 0394-9001 (Print)
IS  - 0394-9001 (Linking)
VI  - 23
IP  - 3
DP  - 2011
TI  - [From disease's treatment to global care of the child with acute lymphoblastic
      leukemia].
PG  - 869-900
AB  - The history of the treatment of childhood acute leukemia is a meaningful model of
      the ethical, bioethical and organizational implications of the technical progress
      in medicine. This experience provides indications and very useful tools to face
      the main topics of modern medicine: the risk of intense medicalization to the
      detriment of the quality of the care, the importance of psycho-emotive, ethical
      and spiritual aspects in the doctor-patient relationship, etc. The Authors report
      the difficulties and progresses until and after the first cures of children with 
      leukemia in the Pediatric Clinic of the University "La Sapienza" of Rome (1964), 
      the new features of treated leukemia (the real disease of cured child") and the
      psycho-emotive involvement of the pediatric staff a "parallel disease"). The
      necessity of a continuous activity aimed at the adaptation of services to
      scientific and medical progress and to the necessity of humanization of
      procedures and environment is stressed.
FAU - Digilio, Girolamo
AU  - Digilio G
AD  - Servizio di Ematologia Pediatrica, Clinica Pediatrica dell'Universita "La
      Sapienza" di Roma, I. girodi@tiscali.it
FAU - Digilio, Marina
AU  - Digilio M
LA  - ita
PT  - English Abstract
PT  - Historical Article
PT  - Journal Article
TT  - Anni '60-'90: dal trattamento della malattia alla presa in carico globale del
      bambino con leucemia linfoblastica acuta.
PL  - Italy
TA  - Med Secoli
JT  - Medicina nei secoli
JID - 0176472
MH  - Child
MH  - Clinical Trials as Topic/history
MH  - *Disease Management
MH  - Female
MH  - Hematology/organization & administration
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Hospitals, University/history
MH  - Humans
MH  - Male
MH  - Outpatient Clinics, Hospital/history
MH  - Pain/etiology/psychology
MH  - Parents/psychology
MH  - Pediatrics/organization & administration
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*history/psychology/therapy
MH  - Rome
MH  - Societies, Medical/history
MH  - Stress, Psychological/etiology/therapy
EDAT- 2011/01/01 00:00
MHDA- 2012/12/10 06:00
CRDT- 2012/10/13 06:00
PHST- 2012/10/13 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
PST - ppublish
SO  - Med Secoli. 2011;23(3):869-900.


PMID- 22997878
OWN - NLM
STAT- MEDLINE
DCOM- 20121011
LR  - 20151119
IS  - 0300-5038 (Print)
IS  - 0300-5038 (Linking)
IP  - 163
DP  - 2011
TI  - Studies in children.
PG  - 475-92
AB  - This chapter first discusses the urgent need for prevention of childhood diseases
      that impose a huge and growing burden on families and society. It provides a
      review of recent research in this area to illustrate both the strengths and
      limitations of molecular epidemiology in drawing needed links between
      environmental exposures and illness in children. For illustration, three of the
      major diseases in children are discussed: asthma, cancer and developmental
      disorders. All three impose significant difficulties, have increased in recent
      decades, and are thought to be caused in substantial part by environmental
      factors, such as toxic exposures due to lifestyle choices (i.e. smoking and
      diet), pollutants in the workplace, ambient air, water and the food supply. These
      exogenous exposures can interact with "host" factors, such as genetic
      susceptibility and nutritional deficits, to cause disease. Molecular epidemiology
      has provided valuable new insights into the magnitude and diversity of exposures 
      beginning in utero, the unique susceptibility of the young, and the adverse
      preclinical and clinical effects resulting from the interactions between these
      factors. However, molecular epidemiology also faces certain constraints and
      challenges that are specific to studies of the very young, including ethical
      issues, technical issues due to the limited amount of biological specimens that
      can be obtained, and communication of results to parents and communities. These
      challenges are particularly apparent when incorporating the newer epigenetic and 
      "omic" techniques and biomarkers into studies of children's diseases.
FAU - Perera, Frederica P
AU  - Perera FP
AD  - Columbia University, New York, NY, USA. fpp1@columbia.edu
FAU - Edwards, Susan C
AU  - Edwards SC
LA  - eng
GR  - 5P01ES09600/ES/NIEHS NIH HHS/United States
GR  - 5R01ES101654/ES/NIEHS NIH HHS/United States
GR  - R01ES09089/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - France
TA  - IARC Sci Publ
JT  - IARC scientific publications
JID - 8009542
RN  - 0 (Biomarkers)
SB  - IM
MH  - Biomarkers/*analysis
MH  - Child
MH  - Disease Susceptibility
MH  - Genetic Diseases, Inborn/*diagnosis/*prevention & control
MH  - Humans
MH  - *Molecular Epidemiology
MH  - Risk Factors
EDAT- 2011/01/01 00:00
MHDA- 2012/10/12 06:00
CRDT- 2012/09/25 06:00
PHST- 2012/09/25 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2012/10/12 06:00 [medline]
PST - ppublish
SO  - IARC Sci Publ. 2011;(163):475-92.


PMID- 22997854
OWN - NLM
STAT- MEDLINE
DCOM- 20121011
LR  - 20120924
IS  - 0300-5038 (Print)
IS  - 0300-5038 (Linking)
IP  - 163
DP  - 2011
TI  - Ethical issues in molecular epidemiologic research.
PG  - 9-22
FAU - Schulte, Paul A
AU  - Schulte PA
AD  - National Institute for Occupational Safety and Health, Cincinnati, OH, USA.
      pas4@cdc.gov
FAU - Smith, Andrea
AU  - Smith A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - France
TA  - IARC Sci Publ
JT  - IARC scientific publications
JID - 8009542
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Conflict of Interest
MH  - *Epidemiologic Studies
MH  - *Ethics, Medical
MH  - Humans
EDAT- 2011/01/01 00:00
MHDA- 2012/10/12 06:00
CRDT- 2012/09/25 06:00
PHST- 2012/09/25 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2012/10/12 06:00 [medline]
PST - ppublish
SO  - IARC Sci Publ. 2011;(163):9-22.


PMID- 22997848
OWN - NLM
STAT- MEDLINE
DCOM- 20121011
LR  - 20181201
IS  - 1556-8539 (Print)
IS  - 1556-8539 (Linking)
VI  - 6
IP  - 2
DP  - 2011
TI  - Human placental stem cells: biomedical potential and clinical relevance.
PG  - 75-92
AB  - Emerging evidence shows that different adult tissues of the human body harbour
      small amounts of adult mesenchymal stem cells (MSCs) which have the potential to 
      give a rise to all cell types of the specific tissue in which they reside. These 
      cells were found in human adult bone marrow, muscle, fat, brain, cartilage,
      dental pulp, etc. Depending on the type of host tissue as well as age and state
      of the donor's health, the plasticity of MSCs can vary considerably. Previously
      accomplished research efforts have shown that adult MSCs have a broad therapeutic
      potential due to their ability to differentiate towards multiple adult cell types
      under appropriate conditions. This unique property characterizes adult MSCs as
      potential candidates for biomedical and clinical applications. In the last decade
      human extra-embryonic tissues (placenta, amniotic membranes, and umbilical cord) 
      as well as human placental fluids (amniotic fluid and umbilical cord blood), were
      also defined as sources of MSCs, which represents a great interest for the
      biomedical applications. Human placenta is a feto-maternal organ which works as a
      natural barrier between mother and foetus and playing a crucial role for the
      nutrition and immune-tolerance during the whole period of the fetal development. 
      Anatomically, the placenta can be divided in four regions: amniotic epithelial,
      amniotic mesenchymal, chorionic mesenchymal and chorionic trophoblastic.
      Immunomodulatory properties of human placenta as well as the clinical
      applicability of such placental parts as amniotic membranes for wound healing,
      treatment of burns, and reconstruction of the oral cavity, will be described. Due
      to the specific structure and functions of placenta, human extra-embryonic MSCs
      represent stem cell types which combine some properties of pluripotent embryonic 
      stem cells with other properties of multipotent mesenchymal stem cells. Due to
      the close ontogenic relationship to embryonic stem cells, MSCs derived from
      different placental regions as well as from amniotic fluid and umbilical cord
      blood have immunoprivileged characteristics, posses a broader plasticity, and
      proliferate faster than adult MSCs. Moreover, the human placenta is normally
      discarded after birth, and cells can be isolated avoiding any ethical concerns.
      In this review we summarize and discuss different aspects of development,
      ontogenetic properties, plasticity, and immunomodulatory characteristics of MSCs 
      from different placental regions as well as from amniotic fluid and umbilical
      cord blood. In addition the potential of placental MSCs for biomedical and
      clinical applications are discussed.
FAU - Malek, Antoine
AU  - Malek A
AD  - Department of Obstetrics, University Hospital Zurich, Research Division,
      Frauenklinikstr. 10, 8091 Zurich, Switzerland. antoine.malek1@gmail.com
FAU - Bersinger, Nick A
AU  - Bersinger NA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Stem Cells
JT  - Journal of stem cells
JID - 101295936
SB  - IM
MH  - Adult
MH  - *Biomedical Technology
MH  - Cell Differentiation
MH  - *Cell- and Tissue-Based Therapy
MH  - Embryonic Stem Cells/*cytology
MH  - Female
MH  - Humans
MH  - Mesenchymal Stem Cells/*cytology/*physiology
MH  - Placenta/*cytology/*physiology
MH  - Pregnancy
EDAT- 2011/01/01 00:00
MHDA- 2012/10/12 06:00
CRDT- 2012/09/25 06:00
PHST- 2012/09/25 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2012/10/12 06:00 [medline]
PST - ppublish
SO  - J Stem Cells. 2011;6(2):75-92.


PMID- 22977961
OWN - NLM
STAT- MEDLINE
DCOM- 20121025
LR  - 20161021
IS  - 1134-7198 (Print)
IS  - 1134-7198 (Linking)
IP  - 34
DP  - 2011 Jan-Jun
TI  - Genomic research with human samples. Points of view from scientists and research 
      subjects about disclosure of results and risks of genomic research. Ethical and
      empirical approach.
PG  - 205-24
AB  - Biomedical researchers often now ask subjects to donate samples to be deposited
      in biobanks. This is not only of interest to researchers, patients and society as
      a whole can benefit from the improvements in diagnosis, treatment, and prevention
      that the advent of genomic medicine portends. However, there is a growing debate 
      regarding the social and ethical implications of creating biobanks and using
      stored human tissue samples for genomic research. Our aim was to identify factors
      related to both scientists and patients' preferences regarding the sort of
      information to convey to subjects about the results of the study and the risks
      related to genomic research. The method used was a survey addressed to 204
      scientists and 279 donors from the U.S. and Spain. In this sample, researchers
      had already published genomic epidemiology studies; and research subjects had
      actually volunteered to donate a human sample for genomic research. Concerning
      the results, patients supported more frequently than scientists their right to
      know individual results from future genomic research. These differences were
      statistically significant after adjusting by the opportunity to receive genetic
      research results from the research they had previously participated and their
      perception of risks regarding genetic information compared to other clinical
      data. A slight majority of researchers supported informing participants about
      individual genomic results only if the reliability and clinical validity of the
      information had been established. Men were more likely than women to believe that
      patients should be informed of research results even if these conditions were not
      met. Also among patients, almost half of them would always prefer to be informed 
      about individual results from future genomic research. The three main factors
      associated to a higher support of a non-limited access to individual results
      were: being from the US, having previously been offered individual information
      and considering genomic data more sensitive than other personal medical data.
      Moreover, the disease of patients, the educational level and the patient's
      country of origin were factors associated with the perception of risks related to
      genomic information. As a conclusion, it is mandatory to clarify the criteria
      required to establish when individual results from genomic research should be
      offered to participants.
FAU - Valle Mansilla, Jose Ignacio
AU  - Valle Mansilla JI
AD  - ignaciovalle@hotmail.com
LA  - eng
PT  - Journal Article
PL  - Spain
TA  - Rev Derecho Genoma Hum
JT  - Revista de derecho y genoma humano = Law and the human genome review
JID - 101558644
SB  - IM
MH  - Attitude
MH  - Female
MH  - Genetic Research/*ethics
MH  - *Genome, Human
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Spain
MH  - *Surveys and Questionnaires
MH  - United States
EDAT- 2011/01/01 00:00
MHDA- 2012/10/26 06:00
CRDT- 2012/09/18 06:00
PHST- 2012/09/18 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2012/10/26 06:00 [medline]
PST - ppublish
SO  - Rev Derecho Genoma Hum. 2011 Jan-Jun;(34):205-24.


PMID- 22977959
OWN - NLM
STAT- MEDLINE
DCOM- 20121025
LR  - 20161021
IS  - 1134-7198 (Print)
IS  - 1134-7198 (Linking)
IP  - 34
DP  - 2011 Jan-Jun
TI  - Genetic privacy and non-discrimination.
PG  - 141-51
AB  - The UN Inter-Agency Committee on Bioethics met for its tenth meeting at the
      UNESCO headquarters in Paris on 4-5th March 2011. Member organisations such as
      the WHO and UNESCO were in attendance alongside associate members such as the
      Council for Europe, the European Commission, the Organisation for Economic
      Co-operation and Development and the World Trade Organisation. Discussion centred
      on the theme "genetic privacy and nondiscrimination". The United Nations Economic
      and Social Council (ECOSOC) had previously considered, from a legal and ethical
      perspective, the implications of increasingly sophisticated technologies for
      genetic privacy and non-discrimination in fields such as medicine, employment and
      insurance. Thus, the ECOSOC requested that UNESCO report on relevant developments
      in the field of genetic privacy and non-discrimination. In parallel with a
      consultation process with member states, UNESCO launched a consultation with the 
      UN Interagency Committee on Bioethics. This article analyses the report presented
      by the author concerning the analysis of the current contentions in the field and
      illustrates attempts at responding on a normative level to a perceived threat to 
      genetic privacy and non-discrimination.
FAU - Romeo Casabona, Carlos Maria
AU  - Romeo Casabona CM
AD  - University of Deusto, Bilbao, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Spain
TA  - Rev Derecho Genoma Hum
JT  - Revista de derecho y genoma humano = Law and the human genome review
JID - 101558644
SB  - IM
MH  - Genetic Privacy/*ethics/*legislation & jurisprudence
MH  - Humans
MH  - *Prejudice
EDAT- 2011/01/01 00:00
MHDA- 2012/10/26 06:00
CRDT- 2012/09/18 06:00
PHST- 2012/09/18 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2012/10/26 06:00 [medline]
PST - ppublish
SO  - Rev Derecho Genoma Hum. 2011 Jan-Jun;(34):141-51.


PMID- 22969181
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 0976-2795 (Electronic)
IS  - 0972-6748 (Linking)
VI  - 20
IP  - 1
DP  - 2011 Jan
TI  - Understanding sexuality among Indian urban school adolescents.
PG  - 49-55
LID - 10.4103/0972-6748.98416 [doi]
AB  - CONTEXT: Adolescence is a very exciting phase of life fraught with many
      challenges like sexuality. Understanding them is important in helping the
      adolescents grow up healthily. AIMS: To ascertain the attitudes and knowledge
      about sexuality among school-going adolescents. SETTINGS AND DESIGN: Students in 
      two urban schools of an Indian city from class IX to XII were administered a
      self-reporting questionnaire on matters related to sexuality. MATERIALS AND
      METHODS: Requisite ethical clearances were taken as also the consent of the
      parents and students before administration of the questionnaire. The authors
      clarified doubts to adolescents. STATISTICAL ANALYSIS: Statistical package for
      social sciences. RESULTS: The incidence of having sexual contact was 30.08% for
      boys and 17.18% for girls. 6.31% boys and 1.31% girls reported having had
      experienced sexual intercourse. Friends constituted the main sexual partners for 
      both boys and girls. Sexual abuse had been reported by both girls and boys. These
      and other findings are discussed in the article. CONCLUSIONS: Adolescent school
      students are involved in sexual activity, but lack adequate knowledge in this
      regard. Students, teachers, and parents need to understand various aspects of
      sexuality to be able to help adolescents' healthy sexual development.
FAU - Ramadugu, Shashikumar
AU  - Ramadugu S
AD  - Department of Psychiatry, Armed Forces Medical College, Pune, Maharashtra, India.
FAU - Ryali, Vssr
AU  - Ryali V
FAU - Srivastava, K
AU  - Srivastava K
FAU - Bhat, P S
AU  - Bhat PS
FAU - Prakash, J
AU  - Prakash J
LA  - eng
PT  - Journal Article
PL  - India
TA  - Ind Psychiatry J
JT  - Industrial psychiatry journal
JID - 101547239
PMC - PMC3425247
OTO - NOTNLM
OT  - Adolescent
OT  - Indian
OT  - school
OT  - sexuality
OT  - urban
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2012/09/13 06:00
PHST- 2012/09/13 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - 10.4103/0972-6748.98416 [doi]
AID - IPJ-20-49 [pii]
PST - ppublish
SO  - Ind Psychiatry J. 2011 Jan;20(1):49-55. doi: 10.4103/0972-6748.98416.


PMID- 22891504
OWN - NLM
STAT- MEDLINE
DCOM- 20120911
LR  - 20191112
IS  - 0739-6686 (Print)
IS  - 0739-6686 (Linking)
VI  - 29
DP  - 2011
TI  - Development of the essential genetic and genomic competencies for nurses with
      graduate degrees.
PG  - 173-90
AB  - Scientific advances in genetics and genomics are rapidly redefining our
      understanding of health and illness and creating a significant shift in practice 
      for all health care disciplines. Nurses educated at the graduate level are
      well-prepared to assume clinical and leadership roles in health care systems and 
      must also be prepared to assume similar roles related to genetic/genomic health
      care. This chapter describes the processes used to create a consensus document
      identifying the genetic/genomic competencies essential for nurses prepared at the
      graduate level. Three groups were involved in the competency development; a
      steering committee provided leadership and used qualitative methods to review and
      analyze pertinent source documents and create an initial competency draft; an
      advisory board evaluated and revised the draft, and a consensus panel refined and
      validated the final set of competencies. The concensus process resulted in 38
      competencies organized under the following categories: risk assessment and
      interpretation; genetic education, counseling, testing and results
      interpretation; clinical management; ethical, legal, and social implications;
      professional role; leadership, and research. These competencies apply to all
      individuals functioning at the graduate level in nursing, including but not
      limited to advanced practice registered nurses, clinical nurse leaders, nurse
      educators, nurse administrators, and nurse scientists and are intended to inform 
      and guide their practice.
FAU - Greco, Karen E
AU  - Greco KE
AD  - National Institutes of Health, National Cancer Institute, Center for Cancer
      Research, Genetics Branch, Bethesda, USA.
FAU - Tinley, Susan
AU  - Tinley S
FAU - Seibert, Diane
AU  - Seibert D
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Annu Rev Nurs Res
JT  - Annual review of nursing research
JID - 8406387
SB  - IM
MH  - *Clinical Competence
MH  - Education, Nursing, Graduate/*methods/*standards
MH  - Genetic Diseases, Inborn/genetics/nursing
MH  - Genetics/*education/trends
MH  - Genomics/*education/trends
MH  - Humans
EDAT- 2011/01/01 00:00
MHDA- 2012/09/12 06:00
CRDT- 2012/08/16 06:00
PHST- 2012/08/16 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2012/09/12 06:00 [medline]
AID - 10.1891/0739-6686.29.173 [doi]
PST - ppublish
SO  - Annu Rev Nurs Res. 2011;29:173-90. doi: 10.1891/0739-6686.29.173.


PMID- 22891502
OWN - NLM
STAT- MEDLINE
DCOM- 20120911
LR  - 20191112
IS  - 0739-6686 (Print)
IS  - 0739-6686 (Linking)
VI  - 29
DP  - 2011
TI  - Stop, look, and listen: revisiting the involvement of children and adolescents in
      genomic research.
PG  - 133-49
AB  - The intersection of the genomic era and information age has created novel
      ethical, legal, and social issues that may be beyond the reach of existing
      guidelines for children and adolescents in research. By taking the opportunity to
      stop, to look, and to listen, nurses are in an ideal situation to help children, 
      adolescents, and families understand these emerging and important issues. This
      chapter thus reviews and highlights the issues and challenges that arise when
      children and adolescents are involved in genomic research. First, we stop and
      review existing guidelines for the protection of individual children and
      adolescents in research and existing gaps and inconsistencies in their
      implementation. Then we take a closer look at the unique features of genetic and 
      genomic research that create particular ethical challenges for completing the
      informed consent process when the research participant is a child or adolescent. 
      Finally, we challenge nurses to listen more intently to what children and their
      families need to know before they are included in genetic and genomic research.
      We emphasize the changing context of children's lives today and the emergence of 
      their decision-making skills.
FAU - Driessnack, Martha
AU  - Driessnack M
AD  - College of Nursing, The University of Iowa, Iowa City, USA.
FAU - Gallo, Agatha M
AU  - Gallo AM
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Annu Rev Nurs Res
JT  - Annual review of nursing research
JID - 8406387
SB  - IM
MH  - Adolescent
MH  - Biomedical Research/*ethics/trends
MH  - Child
MH  - Genomics/*ethics/trends
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Patient Advocacy/*ethics
MH  - Pediatric Nursing/*ethics
EDAT- 2011/01/01 00:00
MHDA- 2012/09/12 06:00
CRDT- 2012/08/16 06:00
PHST- 2012/08/16 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2012/09/12 06:00 [medline]
AID - 10.1891/0739-6686.29.133 [doi]
PST - ppublish
SO  - Annu Rev Nurs Res. 2011;29:133-49. doi: 10.1891/0739-6686.29.133.


PMID- 22891501
OWN - NLM
STAT- MEDLINE
DCOM- 20120911
LR  - 20211021
IS  - 0739-6686 (Print)
IS  - 0739-6686 (Linking)
VI  - 29
DP  - 2011
TI  - Newborn screening: ethical, legal, and social implications.
PG  - 113-32
AB  - Newborn dried blood spot screening (NBS) is a core public health service and is
      the largest application of genetic testing in the United States. NBS is conducted
      by state public health departments to identify infants with certain genetic,
      metabolic, and endocrine disorders. Screening is performed in the first few days 
      of life through blood testing. Several drops of blood are taken from the baby's
      heel and placed on a filter paper card. The dried blood, on the filter cards, is 
      sent from the newborn nursery to the state health department laboratory, or a
      commercial partner, where the blood is analyzed. Scientific and technological
      advances have lead to a significant expansion in the number of tests-from an
      average of 6 to more than 50--and there is a national trend to further expand the
      NBS program. This rapid expansion has created significant ethical, legal, and
      social challenges for the health care system and opportunity for scholarly
      inquiry to address these issues. The purpose of this chapter is to provide an
      overview of the NBS programs and to provide an in-depth examination of two
      significant concerns raised from expanded newborn screening, specifically
      false-positives and lack of information for parents. Implications for nursing
      research in managing these ethical dilemmas are discussed.
FAU - Anderson, Rebecca
AU  - Anderson R
AD  - University of Utah College of Nursing, Salt Lake City, USA.
FAU - Rothwell, Erin
AU  - Rothwell E
FAU - Botkin, Jeffrey R
AU  - Botkin JR
LA  - eng
GR  - R01 HD069045/HD/NICHD NIH HHS/United States
GR  - R01 HG004970/HG/NHGRI NIH HHS/United States
GR  - R01 HG006266/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Annu Rev Nurs Res
JT  - Annual review of nursing research
JID - 8406387
SB  - IM
MH  - Genetic Counseling/ethics/legislation & jurisprudence
MH  - Genetic Testing/*ethics/*legislation & jurisprudence
MH  - Humans
MH  - Infant, Newborn
MH  - Neonatal Nursing/*ethics/*legislation & jurisprudence
MH  - *Neonatal Screening/ethics/legislation & jurisprudence/nursing
MH  - Public Health/ethics/legislation & jurisprudence
MH  - Social Values
MH  - United States
PMC - PMC7768912
MID - NIHMS1654545
EDAT- 2011/01/01 00:00
MHDA- 2012/09/12 06:00
CRDT- 2012/08/16 06:00
PHST- 2012/08/16 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2012/09/12 06:00 [medline]
AID - 10.1891/0739-6686.29.113 [doi]
PST - ppublish
SO  - Annu Rev Nurs Res. 2011;29:113-32. doi: 10.1891/0739-6686.29.113.


PMID- 22689843
OWN - NLM
STAT- MEDLINE
DCOM- 20130919
LR  - 20211021
IS  - 1757-790X (Electronic)
IS  - 1757-790X (Linking)
VI  - 2011
DP  - 2011 Jul 28
TI  - Dilated neonatal cisterna magna and Marfan syndrome.
LID - 10.1136/bcr.06.2011.4328 [doi]
LID - bcr0620114328 [pii]
AB  - The authors report the incidental finding of a dilated cisterna magna with an
      abnormal configuration to the falx in a newborn infant with Marfan syndrome who
      was recruited to a research study involving whole body MRI. To our knowledge,
      dilation of the cisterna magna has not previously been reported in patients with 
      Marfan syndrome. Potential implications for antenatal diagnosis, the ethics of
      recruiting healthy volunteers for research and directions for future work are
      discussed.
FAU - Vasu, Vimal
AU  - Vasu V
AD  - Department of Child Health, William Harvey Hospital, Ashford, Kent, UK.
      vimal.vasu@ekht.nhs.uk
FAU - Child, Anne H
AU  - Child AH
FAU - Modi, Neena
AU  - Modi N
FAU - Rutherford, Mary
AU  - Rutherford M
FAU - Cowan, Frances
AU  - Cowan F
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20110728
PL  - England
TA  - BMJ Case Rep
JT  - BMJ case reports
JID - 101526291
SB  - IM
MH  - Cisterna Magna/*diagnostic imaging
MH  - Diagnosis, Differential
MH  - Echocardiography
MH  - Humans
MH  - Incidental Findings
MH  - Infant, Newborn
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Marfan Syndrome/*diagnosis/diagnostic imaging
PMC - PMC3149446
EDAT- 2011/01/01 00:00
MHDA- 2013/09/21 06:00
CRDT- 2012/06/13 06:00
PHST- 2012/06/13 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2013/09/21 06:00 [medline]
AID - bcr.06.2011.4328 [pii]
AID - 10.1136/bcr.06.2011.4328 [doi]
PST - epublish
SO  - BMJ Case Rep. 2011 Jul 28;2011. pii: bcr.06.2011.4328. doi:
      10.1136/bcr.06.2011.4328.


PMID- 22679532
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1981-8254 (Print)
IS  - 1981-8254 (Linking)
VI  - 5
IP  - 4
DP  - 2011
TI  - THE TOPIC OF RESEARCH INTEGRITY IN LATINAMERICA.
PG  - 362-368
AB  - Present article narrates the experience of trainees of the ethics of biomedical
      and psychosocial research program of the Interdisciplinary Center for studies on 
      bioethics (CIEB) of the University of Chile on the topic of research integrity in
      Latin America. The following problems are covered: integrity of publications,
      reporting of scientific research misconduct, definitions of research integrity,
      scientific ethical review committees functioning, international multi-centric
      clinical trials monitoring and norms for scientific integrity and ethical
      oversight.
FAU - Rodriguez, Eduardo
AU  - Rodriguez E
AD  - Centro Interdisciplinario de Estudios en Bioetica, Universidad de Chile.
FAU - Lolas, Fernando
AU  - Lolas F
LA  - eng
GR  - R25 TW006056/TW/FIC NIH HHS/United States
GR  - R25 TW006056-08/TW/FIC NIH HHS/United States
PT  - Journal Article
PL  - Brazil
TA  - Bioethikos
JT  - Bioethikos
JID - 101473251
PMC - PMC3367392
MID - NIHMS360678
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2012/06/09 06:00
PHST- 2012/06/09 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
PST - ppublish
SO  - Bioethikos. 2011;5(4):362-368.


PMID- 22655235
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 2234-943X (Electronic)
IS  - 2234-943X (Linking)
VI  - 1
DP  - 2011
TI  - Proton Therapy: Ever Shifting Sands and the Opportunities and Obligations within.
PG  - 24
LID - 10.3389/fonc.2011.00024 [doi]
AB  - Proton therapy is associated with significant benefit in terms of normal tissue
      sparing and potential radiation dose escalation for many patients with malignant 
      diseases. Due to recognition of these qualities, the availability of this
      technology is increasing rapidly, both through increased availability of large
      centers, and with the possibility of smaller, lower cost proton therapy centers. 
      Such expansion is associated with increased opportunity to provide this
      beneficial technology to larger numbers of patients; however, the importance of
      careful treatment planning and delivery, deliberate patient selection, rigorous
      scientific investigation including comparison to other technologies when
      possible, and mindfulness of ethical issues and cost effectiveness must not be
      forgotten. The obligation to move forward responsibly rests on the shoulders of
      radiation oncologists around the world. In this article, we discuss current use
      of proton therapy worldwide, as well as many of the factors that must be taken
      into account during rapid expansion of this exciting technology.
FAU - Hill-Kayser, Christine E
AU  - Hill-Kayser CE
AD  - Department of Radiation Oncology, Perelman School of Medicine at the University
      of Pennsylvania Philadelphia, PA, USA.
FAU - Both, Stefan
AU  - Both S
FAU - Tochner, Zelig
AU  - Tochner Z
LA  - eng
PT  - Journal Article
DEP - 20110906
PL  - Switzerland
TA  - Front Oncol
JT  - Frontiers in oncology
JID - 101568867
PMC - PMC3355860
OTO - NOTNLM
OT  - Bragg-peak
OT  - proton therapy
OT  - radiation
OT  - radiation treatment planning
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2012/06/02 06:00
PHST- 2011/07/12 00:00 [received]
PHST- 2011/08/11 00:00 [accepted]
PHST- 2012/06/02 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - 10.3389/fonc.2011.00024 [doi]
PST - epublish
SO  - Front Oncol. 2011 Sep 6;1:24. doi: 10.3389/fonc.2011.00024. eCollection 2011.


PMID- 22649372
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 2
DP  - 2011
TI  - Developments in the imaging of brown adipose tissue and its associations with
      muscle, puberty, and health in children.
PG  - 33
LID - 10.3389/fendo.2011.00033 [doi]
AB  - Fusion positron emission and computed tomography (PET/CT) remains the
      gold-standard imaging modality to non-invasively study metabolically active brown
      adipose tissue (BAT). It has been widely applied to studies in adult cohorts. In 
      contrast, the number of BAT studies in children has been few. This is largely
      limited by the elevated risk of ionizing radiation and radionuclide tracer usage 
      by PET/CT and the ethical restriction of performing such exams on healthy
      children. However, metabolically active BAT has a significantly higher prevalence
      in pediatric patients, according to recent literature. Young cohorts thus
      represent an ideal population to examine the potential relationships of BAT to
      muscle development, puberty, disease state, and the accumulation of white adipose
      tissue. In turn, magnetic resonance imaging (MRI) represents the most promising
      modality to overcome the limitations of PET/CT. The development of rapid,
      repeatable MRI techniques to identify and quantify both metabolically active and 
      inactive BAT non-invasively and without the use of exogenous contrast agents or
      the need for sedation in pediatric patients are critically needed to advance our 
      knowledge of this tissue's physiology.
FAU - Hu, Houchun H
AU  - Hu HH
AD  - Departments of Radiology and Pediatrics, Children's Hospital of Los Angeles, Keck
      School of Medicine, University of Southern California Los Angeles, CA, USA.
FAU - Gilsanz, Vicente
AU  - Gilsanz V
LA  - eng
GR  - K25 DK087931/DK/NIDDK NIH HHS/United States
GR  - R21 DK090778/DK/NIDDK NIH HHS/United States
PT  - Journal Article
DEP - 20110922
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
PMC - PMC3355993
OTO - NOTNLM
OT  - Hounsfield units
OT  - MRI
OT  - PET/CT
OT  - brown adipose tissue
OT  - children
OT  - muscle
OT  - puberty
OT  - white adipose tissue
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2012/06/01 06:00
PHST- 2011/07/19 00:00 [received]
PHST- 2011/08/31 00:00 [accepted]
PHST- 2012/06/01 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - 10.3389/fendo.2011.00033 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2011 Sep 22;2:33. doi: 10.3389/fendo.2011.00033.
      eCollection 2011.


PMID- 22619867
OWN - NLM
STAT- MEDLINE
DCOM- 20120703
LR  - 20120524
IS  - 1029-0540 (Print)
IS  - 1029-0540 (Linking)
VI  - 47
IP  - 4
DP  - 2011
TI  - Public policy and medical tourism: ethical implications for the Egyptian health
      care system.
PG  - 13-5
AB  - Egypt's medical tourism industry has been experiencing tremendous growth.
      However, Egypt continues to lack the necessary investment in its public health
      system to effectively care for its population. Current policy and the emergence
      of medical tourism have led to unequal health care access, resulting in high a
      prevalence of infectious diseases and lack of resources for its most vulnerable
      populations. As a new Egyptian government emerges, it is important for
      policymakers to understand the critical issues and ethical concerns of existing
      health policy. This understanding may be used to propose new policy that more
      effectively allocates to care for Egypt's population.
FAU - Haley, Bob
AU  - Haley B
AD  - Public Health Department, University of North Florida, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - World Hosp Health Serv
JT  - World hospitals and health services : the official journal of the International
      Hospital Federation
JID - 9441450
MH  - Delivery of Health Care/*ethics
MH  - Egypt
MH  - Health Policy
MH  - *Medical Tourism
MH  - *Public Policy
EDAT- 2011/01/01 00:00
MHDA- 2012/07/04 06:00
CRDT- 2012/05/25 06:00
PHST- 2012/05/25 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2012/07/04 06:00 [medline]
PST - ppublish
SO  - World Hosp Health Serv. 2011;47(4):13-5.


PMID- 22616355
OWN - NLM
STAT- MEDLINE
DCOM- 20120613
LR  - 20191112
IS  - 1612-1783 (Print)
IS  - 1612-1783 (Linking)
VI  - 8
IP  - 1
DP  - 2011
TI  - Combining interdisciplinary and International Medical Graduate perspectives to
      teach clinical and ethical communication using multimedia.
PG  - 41-51
AB  - In Australia, international medical graduates (IMGs) play a crucial role in
      addressing workforce shortages in healthcare. Their ability to deliver safe and
      effective healthcare in an unfamiliar cultural setting is intrinsically tied to
      effective communication. Hospital-based medical clinical educators, who play an
      important role in providing communication training to IMGs, would benefit from
      practical resources and an understanding of the relevant pedagogies to address
      these issues in their teaching. This paper examines the nature of an
      interdisciplinary collaboration to develop multimedia resources for teaching
      clinical and ethical communication to IMGs. We describe the processes and
      dynamics of the collaboration, and outline the methodologies from applied
      linguistics, medical education, and health ethics that we drew upon. The
      multimedia consist of three video clips of challenging communication scenarios as
      well as experienced IMGs talking about communication and ethics. The multimedia
      are supported by teaching guidelines that address relevant disciplinary concerns 
      of the three areas of collaboration. In the paper's discussion we point out the
      pre-conditions that facilitated the interdisciplinary collaboration. We propose
      that such collaborative approaches between the disciplines and participants can
      provide new perspectives to address the multifaceted challenges of clinical
      teaching and practice.
FAU - Woodward-Kron, Robyn
AU  - Woodward-Kron R
AD  - Clinical Communication and Learning Development program, Medical Education Unit, 
      University of Melbourne, Parkville, VIC, Australia. robynwk@unimelb.edu.au
FAU - Flynn, Eleanor
AU  - Flynn E
FAU - Delany, Clare
AU  - Delany C
LA  - eng
PT  - Journal Article
PL  - England
TA  - Commun Med
JT  - Communication & medicine
JID - 101201068
SB  - IM
MH  - Australia
MH  - *Communication
MH  - Cooperative Behavior
MH  - *Cultural Competency
MH  - Decision Making
MH  - Education, Medical, Graduate/*organization & administration
MH  - Ethics, Medical
MH  - Humans
MH  - Interdisciplinary Studies
MH  - Internship and Residency/*organization & administration
EDAT- 2011/01/01 00:00
MHDA- 2012/06/14 06:00
CRDT- 2012/05/24 06:00
PHST- 2012/05/24 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2012/06/14 06:00 [medline]
AID - 10.1558/cam.v8i1.41 [doi]
PST - ppublish
SO  - Commun Med. 2011;8(1):41-51. doi: 10.1558/cam.v8i1.41.


PMID- 22616208
OWN - NLM
STAT- MEDLINE
DCOM- 20120613
LR  - 20120523
IS  - 1557-0541 (Print)
IS  - 1557-0541 (Linking)
VI  - 5
IP  - 4
DP  - 2011 Winter
TI  - Lessons learned in using community-based participatory research to build a
      national diabetes collaborative in Canada.
PG  - 405-15
AB  - BACKGROUND: Using community-based participatory research (CBPR) principles, the
      Canadian First Nations Diabetes Clinical Management Epidemiologic (CIRCLE) study 
      documents the current clinical management of type 2 diabetes (T2DM) and
      complications in 19 partnering First Nations (FN) communities. OBJECTIVES: To
      outline the lessons learned in developing and fostering community health
      partnerships, and demonstrate the feasibility of using CBPR in multisite research
      at a national level. METHODS: Investigators developed investigator-FN community
      partnerships from seven Canadian provinces, and research assistants were hired
      from each community to facilitate data collection. Research assistants randomly
      selected patients from each community's diabetes registry, and audited the charts
      of consenting patients from 2006 to 2009 for diabetes indicators in accordance
      with national diabetes guidelines. LESSONS LEARNED: Lessons learned in using CBPR
      on a national scale are outlined by highlighting challenges and facilitating
      factors associated with (1) building collaborative relationships, (2) culture and
      ethics, (3) collaboration and partnership, and (4) innovative avenues of data
      management and dissemination. Lessons learned include the need for a flexible
      research agenda, clear and mutually agreed upon roles, partnership from all
      community levels including Elders, regional coordinators managing several sites, 
      and wide-scale dissemination methods. CONCLUSION: The CIRCLE national CBPR
      multisite collaborative is unprecedented in Canada, and provides a feasible model
      for other studies. Using CBPR on a national scale exacerbates challenges commonly
      faced with single-site or multisite research, but the benefits provided in
      developing partnerships based on mutual trust and goals makes it of great
      importance.
FAU - Naqshbandi, Mariam
AU  - Naqshbandi M
AD  - Centre for Studies in Family Medicine, Department of Family Medicine, Schulich
      School of Medicine and Dentistry, The University of Western Ontario.
FAU - Harris, Stewart B
AU  - Harris SB
FAU - Macaulay, Ann C
AU  - Macaulay AC
FAU - Comeau, Jinette
AU  - Comeau J
FAU - Piche, Joceline
AU  - Piche J
FAU - Montour-Lazare, Dawn
AU  - Montour-Lazare D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Prog Community Health Partnersh
JT  - Progress in community health partnerships : research, education, and action
JID - 101273946
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Canada/epidemiology
MH  - Community-Based Participatory Research/*organization & administration
MH  - Community-Institutional Relations
MH  - Cooperative Behavior
MH  - Cross-Sectional Studies
MH  - Cultural Competency
MH  - Diabetes Mellitus, Type 2/*epidemiology/prevention & control
MH  - Female
MH  - Humans
MH  - *Indians, North American
MH  - Information Dissemination
MH  - Information Management/organization & administration
MH  - Male
MH  - Middle Aged
MH  - Residence Characteristics
MH  - Socioeconomic Factors
MH  - Young Adult
EDAT- 2011/01/01 00:00
MHDA- 2012/06/14 06:00
CRDT- 2012/05/24 06:00
PHST- 2012/05/24 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2012/06/14 06:00 [medline]
PST - ppublish
SO  - Prog Community Health Partnersh. 2011 Winter;5(4):405-15.


PMID- 22572090
OWN - NLM
STAT- MEDLINE
DCOM- 20150819
LR  - 20120510
IS  - 2617-2402 (Electronic)
IS  - 0333-7308 (Linking)
VI  - 48
IP  - 4
DP  - 2011
TI  - "Transferred to another institution": clinical histories of psychiatric patients 
      murdered in the Nazi "euthanasia" killing program.
PG  - 268-74
AB  - This study aims to examine the practice of medical reporting in a totalitarian
      environment including systematic killing of people with mental illness in Nazi
      Germany. The historical analysis is based on patient documents and administrative
      files at today's District Hospital, Gunzburg, as well as on patient documents of 
      inventory R 179 of the branch office of the Federal Archives (Bundesarchiv) in
      Berlin/Lichterfelde. The paper describes four patient histories and attempts to
      reconstruct some aspects of patients' (mostly institutional) histories against
      the background of the Gunzburg State Hospital serving as an assembly institution 
      in the context of "Aktion T4." There is no certainty regarding the places of
      death of the four patients whose medical documentation is reported. In the
      patient records examined, the practice of medical description and reporting was
      characterized by a mixture of medical terminology, ideological diction and common
      language. The type of medical description and documentation used is an expression
      of stigmatization and discrimination of patients and of traumatizing
      institutional practice, and it reflects institutional violence. It is an ethical 
      responsibility to reconstruct and commemorate the individual histories of
      mentally ill patients who were victims of the program of organized mass killings 
      of people with mental illness. Places of death were camouflaged by the "Aktion
      T4," and there is uncertainty for many patients regarding where they were killed.
FAU - Steger, Florian
AU  - Steger F
AD  - Institute for History and Ethics of Medicine, University of Halle-Wittenberg, MLU
      Halle-Wittenberg, Germany.
FAU - Gorgl, Andreas
AU  - Gorgl A
FAU - Strube, Wolfgang
AU  - Strube W
FAU - Winckelmann, Hans-J
AU  - Winckelmann HJ
FAU - Becker, Thomas
AU  - Becker T
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - Israel
TA  - Isr J Psychiatry Relat Sci
JT  - The Israel journal of psychiatry and related sciences
JID - 8108287
SB  - IM
MH  - Euthanasia/*history
MH  - Genocide/*history
MH  - History, 20th Century
MH  - Humans
MH  - Medical History Taking
MH  - Mental Disorders/*history
MH  - National Socialism/*history
MH  - *Social Stigma
EDAT- 2011/01/01 00:00
MHDA- 2015/08/20 06:00
CRDT- 2012/05/11 06:00
PHST- 2012/05/11 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2015/08/20 06:00 [medline]
PST - ppublish
SO  - Isr J Psychiatry Relat Sci. 2011;48(4):268-74.


PMID- 22519283
OWN - NLM
STAT- MEDLINE
DCOM- 20120522
LR  - 20120423
IS  - 0033-2240 (Print)
IS  - 0033-2240 (Linking)
VI  - 68
IP  - 12
DP  - 2011
TI  - [Transplantation as a care about neighbour health and life].
PG  - 1208-14
AB  - Taking into account current developments in medicine and the increasingly
      extended lifespan of our patients, the role of transplantation and the related
      issues have become increasingly more urgent and have demanded more attention in
      recent years. Transplantation is a branch of medical studies which has been
      developed as a result of the need to find answers to unsuccessful organ
      transplants. Transplants are the future of the contemporary medicine and provide 
      better prospects for patients with defective organs. In spite of the rapid
      development and huge successes achieved in the field of transplantation, the
      major problem we are facing, both in terms of the legal and ethical aspects, is
      the lack of the organ donors. Developing social awareness and continuous
      education can bring about positive changes to the current shortage of donors. The
      role of the church and the media in promoting the importance of organ donation
      will also greatly contribute to the future success of transplantation thus saving
      human lives.
FAU - Kucharska, Ewa
AU  - Kucharska E
AD  - Centrum Medyczne "VADIMED" Krakow.
FAU - Necek, Robert
AU  - Necek R
LA  - pol
PT  - English Abstract
PT  - Journal Article
TT  - Transplantacja jako troska o zycie i zdrowie blizniego.
PL  - Poland
TA  - Przegl Lek
JT  - Przeglad lekarski
JID - 19840720R
SB  - IM
MH  - *Attitude to Health
MH  - Forecasting
MH  - Humans
MH  - Life Expectancy/*trends
MH  - Transplantation/*trends
EDAT- 2011/01/01 00:00
MHDA- 2012/05/23 06:00
CRDT- 2012/04/24 06:00
PHST- 2012/04/24 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2012/05/23 06:00 [medline]
PST - ppublish
SO  - Przegl Lek. 2011;68(12):1208-14.


PMID- 22506435
OWN - NLM
STAT- MEDLINE
DCOM- 20120508
LR  - 20191112
IS  - 0007-5140 (Print)
IS  - 0007-5140 (Linking)
VI  - 85
IP  - 4
DP  - 2011 Winter
TI  - Debating a duty to treat: AIDS and the professional ethics of American medicine.
PG  - 620-49
AB  - A heated ethical and professional debate occurred in the United States in the
      late 1980s over whether doctors had an ethical obligation to treat people with
      AIDS. Sparked by public refusals to treat by physicians, the debate was linked to
      changes in the epidemic and general tensions about the character of the
      profession. Despite widespread public consensus on the existence of a duty, the
      outcome of the debate was limited. Physicians' obligations for HIV/AIDS were
      defined by law; no general and durable obligation in the face of epidemics was
      secured. The professional system proved weak in the face of potential crisis.
FAU - Wallis, Patrick
AU  - Wallis P
AD  - Department of Economic History, London School of Economics. p.h.wallis@lse.ac.uk
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Bull Hist Med
JT  - Bulletin of the history of medicine
JID - 0141233
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/*therapy
MH  - Disease Outbreaks/*ethics
MH  - Ethics, Medical/*history
MH  - History, 20th Century
MH  - Humans
MH  - *Moral Obligations
MH  - Physicians/*ethics
MH  - Refusal to Treat/*ethics
MH  - Societies, Medical/history
MH  - United States
EDAT- 2011/01/01 00:00
MHDA- 2012/05/09 06:00
CRDT- 2012/04/18 06:00
PHST- 2012/04/18 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2012/05/09 06:00 [medline]
AID - 10.1353/bhm.2011.0092 [doi]
PST - ppublish
SO  - Bull Hist Med. 2011 Winter;85(4):620-49. doi: 10.1353/bhm.2011.0092.


PMID- 22489229
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1658-7774 (Electronic)
IS  - 1658-3639 (Linking)
VI  - 5
IP  - 1
DP  - 2011 Jan
TI  - Perceptions of placebo therapy among health practitioners in jazan region of
      saudi arabia.
PG  - 45-9
AB  - BACKGROUND: Placebo therapy has always been a subject of controversy in the field
      of medicine. Some choose to admit it as "fake, irresponsible medicine" while
      others advocate its effectiveness in various clinical settings. With the advent
      of the recent concept of mind-body medicine, placebo has entered from fringe to
      mainstream therapeutics. Some clinicians use it for its actual positive outcomes 
      while others use it merely to buy time until definitive diagnosis or even as a
      pacifier for patients. OBJECTIVE: The present study was carried out to observe
      the perceptions about placebo therapy among health practitioners in Jazan region 
      of Saudi Arabia METHODOLOGY: Data was analyzed through statistical analysis of
      retrospective questionnaires addressing various issues on placebo therapy,
      including types of placebo used in various clinical settings, mechanism of
      placebo action, ethics of use and openness with patients etc. RESULTS: The study 
      elucidated that the perceptions regarding placebo therapy are subjective and
      variable within and between institutions ranging from firm belief in its positive
      effects and efficacy; to neutral attitudes among some, to strong opposition for
      it among still others. CONCLUSION: More research is needed to ethically define
      the boundary between explicit fraudulence and marginalized evidence based
      therapeutic deception to effectively achieve the goal of positive health outcomes
      in patients.
FAU - Hassan, Tabinda
AU  - Hassan T
FAU - Fauzi, Mahmood
AU  - Fauzi M
FAU - Hasan, Deeba
AU  - Hasan D
LA  - eng
PT  - Journal Article
PL  - Saudi Arabia
TA  - Int J Health Sci (Qassim)
JT  - International journal of health sciences
JID - 101528042
PMC - PMC3312768
OTO - NOTNLM
OT  - Placebo therapy
OT  - Saudi Arabia
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2012/04/11 06:00
PHST- 2012/04/11 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
PST - ppublish
SO  - Int J Health Sci (Qassim). 2011 Jan;5(1):45-9.


PMID- 22479893
OWN - NLM
STAT- MEDLINE
DCOM- 20120529
LR  - 20140731
IS  - 0324-0959 (Print)
IS  - 0324-0959 (Linking)
VI  - 50
IP  - 4
DP  - 2011
TI  - [Characteristics of the severe fetalanomalies terminated in general obstetrics
      department for 4,5 years period].
PG  - 22-9
AB  - UNLABELLED: The most common reason for interruption in second trimester is:
      Foetus mortus, malformations, severe intrauterine retardation, oligohydramnios,
      PPOM, cervical insufficiency, incomplete abortion. The aim of this study was to
      evaluate and analyze the distribution of incidence and type of severe fetal
      malformations, terminated at the end of first and second trimester in General
      obstetrical department in University hospital "Maichin dom"- Sofia for a period
      of 4 years and 5 months - retrospectively and prospectively. RESULTS AND
      DISCUSSION: Patients were aged between 16 and 42 years. The termination of
      pregnancies was in gestational period between 11.5 and 28 weeks. The study period
      is from the beginning of 2007 until May 2011. In the department have been
      terminated a total number of 907 pregnancies, 219 cases in second trimester and
      61 of them due to fetal malformation, diagnozed between 11.5 to 28 weeks The
      incidence of fetal abnormalities was 27.8% (61 cases) of all terminated
      pregnancies in second trimester (219 cases). The results showed the highest rate 
      of malformations in the age group 21-35 years - 62.3%. The highest percentage of 
      malformations are in gestational age: 18-22 weeks - 59%. The highest incidence
      are as followed: neural tube defects (24.59%) and central nervous system
      (21.29%), followed by chromosomal defects confirmed by amniocentesis (11.47%),
      cardiac defects (9.83%), facial clefts (6.54%). The most common gestational age
      in which the anomalies are diagnosed and terminated is 18-22 weeks. The upper
      limit for termination of pregnancy on legislation is 22 weeks (globally 22-24
      weeks). Ethical and social considerations in all cases of severe abnormalities
      and possible variations in physical and mental and intellectual development of
      the infant are discussed, these pregnancies, either diagnosed late and/or after
      karyotiping require termination of the pregnancy in late pregnancy
FAU - Tsankova, M
AU  - Tsankova M
FAU - Marinov, B
AU  - Marinov B
LA  - bul
PT  - English Abstract
PT  - Journal Article
PL  - Bulgaria
TA  - Akush Ginekol (Sofiia)
JT  - Akusherstvo i ginekologiia
JID - 0370455
SB  - IM
MH  - *Abortion, Induced/ethics
MH  - Adolescent
MH  - Adult
MH  - Bulgaria/epidemiology
MH  - Female
MH  - Fetal Diseases/epidemiology
MH  - Fetus/*abnormalities
MH  - Humans
MH  - Obstetrics and Gynecology Department, Hospital
MH  - Pregnancy
MH  - Pregnancy Trimester, Second
MH  - Prospective Studies
MH  - Retrospective Studies
MH  - Young Adult
EDAT- 2011/01/01 00:00
MHDA- 2012/05/30 06:00
CRDT- 2012/04/07 06:00
PHST- 2012/04/07 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2012/05/30 06:00 [medline]
PST - ppublish
SO  - Akush Ginekol (Sofiia). 2011;50(4):22-9.


PMID- 22471500
OWN - NLM
STAT- MEDLINE
DCOM- 20120801
LR  - 20170308
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Linking)
VI  - 12
IP  - 12
DP  - 2011
TI  - Diagnostic significance of alpha fetoprotein in carcinomas of liver and biliary
      tract - a comparative study from the western region of Nepal.
PG  - 3475-8
AB  - OBJECTIVE: To assess the diagnostic significance of alpha-fetoprotein in
      carcinomas of liver and biliary tract with the overall goal of reducing morbidity
      and mortality in Pokhara valley. MATERIALS AND METHODS: It was a hospital based
      comparative study carried out in the Department of Biochemistry of Manipal
      Teaching Hospital, Pokhara, Nepal between 1st January 2009 and 31st December
      2010. The variables collected were age, gender, serum alpha feto protein.
      Approval for the study was obtained from the institutional research ethical
      committee. Estimation of AFP was performed by ELISA reader for all cases. The
      standard procedure was followed as per manufacturer's instructions for ELISA. All
      these laboratory parameters were analyzed using Human reagent kits and with the
      help of ELISA and semi autoanalyser (Humalyser 3500, Germany). RESULTS: Out of
      1200 patients, there were 348(29%) cases of HCC. Out of that, 285 cases were
      found to be AFP positive with significant elevation. Furthermore, diagnosed cases
      were of cholangiocarcinomas (96, 8%) and secondary carcinomas of liver (216,
      18%). In both of these clinical conditions, there was insignificant elevation of 
      AFP. Another commonly diagnosed condition was cirrhosis (480, 40%) and in 90
      cases, AFP values were moderately raised from the upper limit of normal reference
      range. The last diagnosed cases were of either Hepatitis A/E(60, 5%) and did not 
      show any rise in levels of AFP. CONCLUSION: Serological markers for
      hepatocellular carcinoma (HCC) are imperative for early identification, as well
      as scrutinizing of tumour aggressiveness, treatment responsiveness, reappearance 
      and endurance. It is consequently justifiable to carry out the test for serum AFP
      to detect and differentiate at early stage of liver cell carcinomas.
FAU - Mittal, Ankush
AU  - Mittal A
AD  - Manipal College of Medical Sciences, Pokhara, Nepal. drmittala@gmail.com
FAU - Sathian, Brijesh
AU  - Sathian B
FAU - Chandrashekharan, Nishida
AU  - Chandrashekharan N
FAU - Farooqui, Shamim Mohammad
AU  - Farooqui SM
FAU - Hussain, Asraf
AU  - Hussain A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (alpha-Fetoproteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biliary Tract Neoplasms/blood/*diagnosis
MH  - Biomarkers, Tumor/*blood
MH  - Carcinoma, Hepatocellular/blood/*diagnosis
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Liver Cirrhosis/blood/*diagnosis
MH  - Liver Neoplasms/blood/*diagnosis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Nepal
MH  - Prognosis
MH  - Young Adult
MH  - alpha-Fetoproteins/*metabolism
EDAT- 2011/01/01 00:00
MHDA- 2012/08/02 06:00
CRDT- 2012/04/05 06:00
PHST- 2012/04/05 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2012/08/02 06:00 [medline]
PST - ppublish
SO  - Asian Pac J Cancer Prev. 2011;12(12):3475-8.


PMID- 22447756
OWN - NLM
STAT- MEDLINE
DCOM- 20130320
LR  - 20181201
IS  - 1940-5529 (Electronic)
IS  - 1940-5529 (Linking)
VI  - 17
IP  - 1
DP  - 2011
TI  - Do people with intellectual disability require special human subjects research
      protections? The interplay of history, ethics, and policy.
PG  - 52-6
LID - 10.1002/ddrr.139 [doi]
AB  - People with intellectual disability (ID) have a long history of discrimination
      and stigmatization, and a more recent history of pride and self-advocacy. The
      early history suggests that people with ID are a vulnerable population and
      deserve special research protections as do some other groups; the disability
      rights movement of the late 20th century aligns people with ID more closely with 
      the principle of autonomy that has guided clinical and research ethics for the
      last 40 years. In examining the history of people with ID and the prevailing
      framework of human subjects research protections in the United States, we
      conclude that people with ID do not require special protection in human subjects 
      research. The protections that have already been put in place for all
      individuals, if conscientiously and effectively implemented, achieve the right
      balance between safeguarding the interest of human research subjects and
      empowering individuals who choose to do so to participate in research.
CI  - Copyright (c) 2012 Wiley Periodicals, Inc.
FAU - Feudtner, Chris
AU  - Feudtner C
AD  - Department of Medical Ethics and Policy Lab, The Children's Hospital of
      Philadelphia North, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
FAU - Brosco, Jeffrey P
AU  - Brosco JP
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Dev Disabil Res Rev
JT  - Developmental disabilities research reviews
JID - 101319448
SB  - IM
MH  - Ethics, Research
MH  - History, 20th Century
MH  - Human Experimentation/*ethics/*legislation & jurisprudence
MH  - Humans
MH  - Intellectual Disability/*history
MH  - Public Policy/*history/legislation & jurisprudence
MH  - United States
EDAT- 2011/01/01 00:00
MHDA- 2013/03/21 06:00
CRDT- 2012/03/27 06:00
PHST- 2012/03/27 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2013/03/21 06:00 [medline]
AID - 10.1002/ddrr.139 [doi]
PST - ppublish
SO  - Dev Disabil Res Rev. 2011;17(1):52-6. doi: 10.1002/ddrr.139.


PMID- 22439296
OWN - NLM
STAT- MEDLINE
DCOM- 20120719
LR  - 20211021
IS  - 0091-2174 (Print)
IS  - 0091-2174 (Linking)
VI  - 42
IP  - 3
DP  - 2011
TI  - Religious, spiritual, and traditional beliefs and practices and the ethics of
      mental health research in less wealthy countries.
PG  - 267-77
AB  - This discussion article contributes to ethics reform by introducing the
      contribution of religious, spiritual, and traditional beliefs and practices to
      both subject vulnerability and patient improvement. A growing body of evidence
      suggests that religious, spiritual, and traditional beliefs and practices may
      provide positive benefits, although in some cases mixed or negative consequences 
      to mental and physical health. These beliefs and practices add a new level of
      complexity to ethical deliberations, in terms of what ignoring them may mean for 
      both distributive justice and respect for persons. International ethical
      guidelines need to be created that are expansive enough to cover an array of
      social groups and circumstances. It is proposed that these guidelines incorporate
      the religious, spiritual, and/or traditional principles that characterize a local
      population. Providing effective mental healthcare requires respecting and
      understanding how differences, including ones that express a population's
      religious, spiritual, or traditional belief systems, play into the complex
      deliberations and negotiations that must be undertaken if researchers are to
      adhere to ethical imperatives in research and treatment.
FAU - Nolan, Jennifer A
AU  - Nolan JA
AD  - Center for Child and Family Policy, Social Science Research Institute, Duke
      University, Durham, North Carolina 27708, USA. jan13@duke.edu
FAU - Whetten, Kathryn
AU  - Whetten K
FAU - Koenig, Harold G
AU  - Koenig HG
LA  - eng
GR  - P30 DA023026/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Psychiatry Med
JT  - International journal of psychiatry in medicine
JID - 0365646
SB  - IM
MH  - *Culture
MH  - *Ethics, Research
MH  - Humans
MH  - Mental Disorders/*psychology
MH  - Mental Health
MH  - *Religion and Medicine
MH  - *Religion and Psychology
MH  - Socioeconomic Factors
PMC - PMC3747831
MID - NIHMS504831
EDAT- 2011/01/01 00:00
MHDA- 2012/07/20 06:00
CRDT- 2012/03/24 06:00
PHST- 2012/03/24 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2012/07/20 06:00 [medline]
AID - 10.2190/PM.42.3.c [doi]
PST - ppublish
SO  - Int J Psychiatry Med. 2011;42(3):267-77. doi: 10.2190/PM.42.3.c.


PMID- 22416620
OWN - NLM
STAT- MEDLINE
DCOM- 20120510
LR  - 20120315
IS  - 0002-7979 (Print)
IS  - 0002-7979 (Linking)
VI  - 78
IP  - 4
DP  - 2011 Winter
TI  - How to make moral choices.
PG  - 56-63
AB  - Moral choice is committing to act for what one believes is right and good. It is 
      less about what we know than about defining who we are. Three cases typical of
      those used in the principles or dilemmas approach to teaching ethics are
      presented. But they are analyzed using an alternative approach based on seven
      moral choice heuristics--approaches proven to increase the likelihood of locating
      the best course of action. The approaches suggested for analyzing moral choice
      situations include: (a) identify the outcomes of available alternative courses of
      action; (b) rule out strategies that involve deception, coercion, reneging on
      promises, collusion, and contempt for others; (c) be authentic (do not deceive
      yourself); (d) relate to others on a human basis; (e) downplay rational
      justifications; (f) match the solution to the problem, not the other way around; 
      (g) execute on the best solution, do not hold out for the perfect one; and (h)
      take action to improve the choice after it has been made.
FAU - Chambers, David W
AU  - Chambers DW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Coll Dent
JT  - The Journal of the American College of Dentists
JID - 7503057
SB  - IM
MH  - Attitude of Health Personnel
MH  - Choice Behavior/*ethics
MH  - Coercion
MH  - Deception
MH  - Dentists/ethics
MH  - Education, Dental/ethics
MH  - *Ethics, Dental/education
MH  - Fraud/ethics
MH  - Humans
MH  - Interpersonal Relations
MH  - *Morals
MH  - Motivation/ethics
MH  - Paternalism/ethics
MH  - Problem Solving/ethics
MH  - Risk Assessment/ethics
MH  - Self Concept
MH  - Sexual Harassment/ethics
MH  - Teaching/methods
MH  - Workplace
EDAT- 2011/01/01 00:00
MHDA- 2012/05/11 06:00
CRDT- 2012/03/16 06:00
PHST- 2012/03/16 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2012/05/11 06:00 [medline]
PST - ppublish
SO  - J Am Coll Dent. 2011 Winter;78(4):56-63.


PMID- 22416619
OWN - NLM
STAT- MEDLINE
DCOM- 20120510
LR  - 20120315
IS  - 0002-7979 (Print)
IS  - 0002-7979 (Linking)
VI  - 78
IP  - 4
DP  - 2011 Winter
TI  - The case of the pregnant adolescent.
PG  - 48-55
AB  - In this case an adolescent, minor female presents herself for routine dental
      care, but is pregnant without parental knowledge. She asks the dentist not to
      reveal the pregnancy to her parents. Three experts including one attorney, one
      dental educator with 25 years of private practice experience, and one member of a
      state psychological association's ethics committee comment on the difficult
      ethical and legal issues found in this actual case.
FAU - Peltier, Bruce N
AU  - Peltier BN
AD  - School of Dentistry, University of the Pacific in San Francisco, USA.
      bpeltier@pacific.edu
FAU - Hoover, Terry
AU  - Hoover T
FAU - Zarkowski, Pamela
AU  - Zarkowski P
FAU - Patterson, Terry
AU  - Patterson T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Coll Dent
JT  - The Journal of the American College of Dentists
JID - 7503057
SB  - IM
MH  - Adolescent
MH  - Confidentiality/ethics/legislation & jurisprudence
MH  - Counseling
MH  - Culture
MH  - Dental Care/*ethics/legislation & jurisprudence
MH  - Dentist-Patient Relations/ethics
MH  - *Ethics, Dental
MH  - Female
MH  - Humans
MH  - Mental Health Services
MH  - *Minors/legislation & jurisprudence
MH  - Parent-Child Relations
MH  - Parental Consent/ethics/legislation & jurisprudence
MH  - Patient Care Team
MH  - Pregnancy
MH  - Pregnancy in Adolescence/*ethics
MH  - Professional-Family Relations/ethics
MH  - Referral and Consultation
MH  - Trust
MH  - Truth Disclosure/ethics
MH  - United States
EDAT- 2011/01/01 00:00
MHDA- 2012/05/11 06:00
CRDT- 2012/03/16 06:00
PHST- 2012/03/16 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2012/05/11 06:00 [medline]
PST - ppublish
SO  - J Am Coll Dent. 2011 Winter;78(4):48-55.


PMID- 22416617
OWN - NLM
STAT- MEDLINE
DCOM- 20120510
LR  - 20191210
IS  - 0002-7979 (Print)
IS  - 0002-7979 (Linking)
VI  - 78
IP  - 4
DP  - 2011 Winter
TI  - The ethics of routine use of advanced diagnostic technology.
PG  - 35-9
FAU - Khelemsky, Renata
AU  - Khelemsky R
AD  - Columbia University College of Dental Medicine, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Coll Dent
JT  - The Journal of the American College of Dentists
JID - 7503057
SB  - IM
MH  - Cone-Beam Computed Tomography/*ethics
MH  - Conflict, Psychological
MH  - Decision Making/ethics
MH  - Dental Care/ethics
MH  - Dentist-Patient Relations/ethics
MH  - Dentists/ethics
MH  - *Ethics, Dental
MH  - Humans
MH  - Informed Consent/ethics
MH  - Moral Obligations
MH  - Patient Participation
MH  - Practice Patterns, Dentists'/ethics
MH  - Radiography, Dental, Digital/*ethics
MH  - Risk Assessment/ethics
MH  - Technology, Dental/*ethics
MH  - Trust
MH  - Truth Disclosure/ethics
MH  - Virtues
EDAT- 2011/01/01 00:00
MHDA- 2012/05/11 06:00
CRDT- 2012/03/16 06:00
PHST- 2012/03/16 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2012/05/11 06:00 [medline]
PST - ppublish
SO  - J Am Coll Dent. 2011 Winter;78(4):35-9.


PMID- 22416613
OWN - NLM
STAT- MEDLINE
DCOM- 20120510
LR  - 20120315
IS  - 0002-7979 (Print)
IS  - 0002-7979 (Linking)
VI  - 78
IP  - 4
DP  - 2011 Winter
TI  - Personal ethical dilemma: is the patient competent?
PG  - 19-21
FAU - Nunes, Alice
AU  - Nunes A
AD  - University of Washington, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Coll Dent
JT  - The Journal of the American College of Dentists
JID - 7503057
SB  - IM
MH  - Aged, 80 and over
MH  - Attitude to Health
MH  - Beneficence
MH  - Decision Making/ethics
MH  - Dental Care for Aged/*ethics
MH  - Dentist-Patient Relations/*ethics
MH  - Dentists/*ethics
MH  - *Ethics, Dental
MH  - Humans
MH  - *Mental Competency
MH  - Patient Advocacy/ethics
MH  - Patient Care Planning/ethics
MH  - Personal Autonomy
MH  - Self Care/ethics
MH  - Social Justice/ethics
EDAT- 2011/01/01 00:00
MHDA- 2012/05/11 06:00
CRDT- 2012/03/16 06:00
PHST- 2012/03/16 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2012/05/11 06:00 [medline]
PST - ppublish
SO  - J Am Coll Dent. 2011 Winter;78(4):19-21.


PMID- 22398340
OWN - NLM
STAT- MEDLINE
DCOM- 20120405
LR  - 20120308
IS  - 1531-2054 (Print)
IS  - 1531-2054 (Linking)
IP  - 21
DP  - 2011
TI  - Thoughts on legal and ethical concepts on the professional development of
      Ayurveda in the U.S.
PG  - 17-20
AB  - The following is a transcript of a talk given by Wynn Werner, who is a board
      member of the National Ayurvedic Medical Association (NAMA) and member of the
      NAMA standards committee, at the NAMA conference in April 2010. In this talk,
      Werner discusses the legal and licensing challenges facing Ayurvedic
      practitioners in the United States. IAYT finds the work of NAMA on the issue of
      professional development to be both educational and thought-provoking for our own
      field's parallel process. We present this transcript to contribute to the
      conversation within the yoga therapy community.
FAU - Werner, Wynn
AU  - Werner W
AD  - National Ayurvedic Medical Association. wwerner@ayurveda.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Int J Yoga Therap
JT  - International journal of yoga therapy
JID - 100965420
SB  - IM
MH  - Humans
MH  - Licensure/*ethics/*legislation & jurisprudence
MH  - *Medicine, Ayurvedic
MH  - Professional Practice/*ethics/*legislation & jurisprudence
MH  - United States
EDAT- 2011/01/01 00:00
MHDA- 2012/04/06 06:00
CRDT- 2012/03/09 06:00
PHST- 2012/03/09 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2012/04/06 06:00 [medline]
AID - U351288337G133XJ [pii]
PST - ppublish
SO  - Int J Yoga Therap. 2011;(21):17-20.


PMID- 22393987
OWN - NLM
STAT- MEDLINE
DCOM- 20120713
LR  - 20220317
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Linking)
VI  - 12
IP  - 11
DP  - 2011
TI  - Water pipe (shisha) smoking and associated factors among Malaysian university
      students.
PG  - 3041-7
AB  - OBJECTIVE: The objective of this study was to determine the prevalence of
      waterpipe (shisha) smoking and associated factors among Malaysian university
      students. METHODOLOGY: A total of 200 university students from Management and
      Science University participated in this study. The survey was conducted by simple
      random sampling by randomly distributing self-administered questionnaires to the 
      library, cafeterias and classes. The protocol of this study was approved by the
      ethics committee of Management and Science University. Consent forms were
      obtained from the students before they answered the questionnaire. Statistical
      analyses were performed using the Statistical Package for Social Science (SPSS)
      version 13. with the Student's t-test for comparison of the mean practice and
      backward multiple linear regression for multivariate analysis. RESULTS: The
      majority of the subjects were male, single, Malay and from urban areas (61.5%,
      94.5%, 66%, 76.5%; respectively). In this study 30% of the study participants
      were shisha smokers. Regarding knowledge about shisha smoking, the majority
      (48.5%) mentioned that shisha is less harmful than cigarettes and 55% reported
      that shisha is less addictive. Univariate analysis showed that age, race, sex and
      income significantly influenced the practice of smoking shisha among university
      students (p=0.019, p=0.002, p=0.001, p=0.018; respectively). For multivariate
      analysis, income and gender demonstrated significant influence (both p=0.001).
      CONCLUSION: There was a high prevalence of shisha smoking among Malaysian
      university students and knowledge about the dangers is low. Income and gender
      significantly influenced the practice of smoking shisha in our population.
      Banning of smoking including shisha smoking in public places is strongly
      recommended.
FAU - Al-Naggar, Redhwan Ahmed
AU  - Al-Naggar RA
AD  - Community Medicine Department, International Medical School, Management and
      Science University, Malaysia. radhwan888@yahoo.com
FAU - Saghir, Fatma S A
AU  - Saghir FS
LA  - eng
PT  - Journal Article
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Malaysia/epidemiology
MH  - Male
MH  - Smoking/*epidemiology
MH  - Students/statistics & numerical data
MH  - Surveys and Questionnaires
MH  - Universities
MH  - Young Adult
EDAT- 2011/01/01 00:00
MHDA- 2012/07/14 06:00
CRDT- 2012/03/08 06:00
PHST- 2012/03/08 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2012/07/14 06:00 [medline]
PST - ppublish
SO  - Asian Pac J Cancer Prev. 2011;12(11):3041-7.


PMID- 22389860
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 2090-6153 (Electronic)
IS  - 2090-6145 (Linking)
VI  - 2011
DP  - 2011
TI  - Human tissue in the evaluation of safety and efficacy of new medicines: a viable 
      alternative to animal models?
PG  - 806789
LID - 10.5402/2011/806789 [doi]
AB  - The pharma Industry's ability to develop safe and effective new drugs to market
      is in serious decline. Arguably, a major contributor to this is the Industry's
      extensive reliance on nonhuman biology-based test methods to determine potential 
      safety and efficacy, objective analysis of which reveals poor predictive value.
      An obvious alternative approach is to use human-based tests, but only if they are
      available, practical, and effective. While in vivo (phase 0 microdosing with high
      sensitivity mass spectroscopy) and in silico (using established human biological 
      data), technologies are increasingly being used, in vitro human approaches are
      more rarely employed. However, not only are increasingly sophisticated in vitro
      test methods now available or under development, but the basic ethically approved
      infrastructure through which human cells and tissues may be acquired is
      established. Along with clinical microdosing and in silico approaches, more
      effective access to and use of human cells and tissues in vitro provide exciting 
      and potentially more effective opportunities for the assessment of safety and
      efficacy of new medicines.
FAU - Coleman, Robert A
AU  - Coleman RA
AD  - 27 Wodehouse Terrace, Falmouth, Cornwall TR11 3EN, UK.
LA  - eng
PT  - Journal Article
DEP - 20110706
PL  - Egypt
TA  - ISRN Pharm
JT  - ISRN pharmaceutics
JID - 101571023
PMC - PMC3263708
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2012/03/06 06:00
PHST- 2011/04/18 00:00 [received]
PHST- 2011/05/15 00:00 [accepted]
PHST- 2012/03/06 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - 10.5402/2011/806789 [doi]
PST - ppublish
SO  - ISRN Pharm. 2011;2011:806789. doi: 10.5402/2011/806789. Epub 2011 Jul 6.


PMID- 22375496
OWN - NLM
STAT- MEDLINE
DCOM- 20120314
LR  - 20181201
IS  - 0377-8231 (Print)
IS  - 0377-8231 (Linking)
VI  - 166
IP  - 3-4
DP  - 2011
TI  - [Utilization of screening and treatment of prostate cancer in 2011].
PG  - 170-6; discussion 177
AB  - Prostate cancer is the most prevalent cancer in men aged fifty or more. Resulting
      mortality, however, is low since most prostatic cancers are slow-growing,
      non-lethal tumours. The introduction of PSA screening has profoundly impacted on 
      the epidemiology of prostate cancer. Men bearing aggressive disease are diagnosed
      sooner so that radical treatment can be applied more effectively. But PSA
      screening also unveil many indolent cancers that would have not threaten the
      patient if left undiscovered. Systematic treatment of indolent cancers may result
      into many men being exposed to unwanted side effects. For this reason, the true
      benefit of PSA screening is still a matter of intense debate. Nevertheless, there
      is room for an ethical approach of prostate cancer screening, based on
      information, correct identification of aggressive disease and early integration
      of new biomarkers.
FAU - Tombal, B
AU  - Tombal B
AD  - Service d'Urologie, Cliniques universitaires Saint-Luc, Universite catholique de 
      Louvain, Bruxelles, Belgique. Bertrand.tombal@uclouvain.be
LA  - fre
PT  - Lecture
TT  - Utilite du depistage et du traitement du cancer de la prostate en 2011.
PL  - Belgium
TA  - Bull Mem Acad R Med Belg
JT  - Bulletin et memoires de l'Academie royale de medecine de Belgique
JID - 7608462
RN  - 0 (Biomarkers, Tumor)
RN  - EC 3.4.21.77 (Prostate-Specific Antigen)
SB  - IM
MH  - Aged
MH  - Biomarkers, Tumor/*blood
MH  - Humans
MH  - Male
MH  - Mass Screening/methods/*statistics & numerical data
MH  - Middle Aged
MH  - Prognosis
MH  - Prostate-Specific Antigen/*blood
MH  - Prostatic Neoplasms/blood/*diagnosis/pathology/*therapy
EDAT- 2011/01/01 00:00
MHDA- 2012/03/15 06:00
CRDT- 2012/03/02 06:00
PHST- 2012/03/02 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2012/03/15 06:00 [medline]
PST - ppublish
SO  - Bull Mem Acad R Med Belg. 2011;166(3-4):170-6; discussion 177.


PMID- 22375492
OWN - NLM
STAT- MEDLINE
DCOM- 20120314
LR  - 20181201
IS  - 0377-8231 (Print)
IS  - 0377-8231 (Linking)
VI  - 166
IP  - 1-2
DP  - 2011
TI  - [Music, composers and psychopathology: the psychiatrist's view].
PG  - 88-96; discussion 97-8
AB  - A first reason for the psychiatrist to be interested in music, musicians and
      their artistic work, comes from the strong biographical and scientific evidence
      linking mood disorders and in particular, bipolar disorder, to artistic
      creativity. Moreover, a family association between psychopathology and creativity
      has been found in several studies. Important changes in mood, but also cognition,
      personality and behaviour can occur during all phases of manic-depressive illness
      and these changes have potentially important effects on creativity and
      productivity. Those changes are usually opposite in mania and depression. Many
      bipolar artists see emotional turmoil as essential to their creativity, which has
      therapeutical but also ethical consequences. A second area of interest is the
      impaired emotional recognition in schizophrenic patients, not only for visual
      material (faces or contextual scenes) but also for auditive material (voice or
      music) leading to impaired social interactions in this condition.
FAU - Constant, E
AU  - Constant E
AD  - Service de psychiatrie adulte, Cliniques universitaires St. Luc, U.C.L.
LA  - fre
PT  - Lecture
TT  - Musique, compositeurs et psychopathologie: regards du psychiatre.
PL  - Belgium
TA  - Bull Mem Acad R Med Belg
JT  - Bulletin et memoires de l'Academie royale de medecine de Belgique
JID - 7608462
SB  - IM
MH  - Affect
MH  - Bipolar Disorder/*psychology
MH  - *Creativity
MH  - Depressive Disorder/psychology
MH  - Humans
MH  - Mood Disorders/*psychology
MH  - Music/*psychology
MH  - Social Behavior
MH  - Social Behavior Disorders/psychology
EDAT- 2011/01/01 00:00
MHDA- 2012/03/15 06:00
CRDT- 2012/03/02 06:00
PHST- 2012/03/02 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2012/03/15 06:00 [medline]
PST - ppublish
SO  - Bull Mem Acad R Med Belg. 2011;166(1-2):88-96; discussion 97-8.


PMID- 22375490
OWN - NLM
STAT- MEDLINE
DCOM- 20120314
LR  - 20120301
IS  - 0377-8231 (Print)
IS  - 0377-8231 (Linking)
VI  - 166
IP  - 1-2
DP  - 2011
TI  - [Should medicine encourage doing? Biomedical engineering ideals and the issue of 
      improving humans].
PG  - 49-58; discussion 59-61
AB  - In the contemporary biomedicine, the new medicines and technologies can be used
      not only to cure the patients but also to enhance human capacities: genetic
      design, alteration of cognitive and emotional functions, increase in life-span,
      or to boost performances in sport... This evolution represents a paradigmatic
      change in the medical practice. It is not the mere restoration of health which is
      expected anymore. What is required is "the perfectibility of the human being". In
      this article, the emergence of the "enhancement technologies" is examined from an
      ethical and philosophical perspective.
FAU - Missa, J-N
AU  - Missa JN
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - La medecine doit-elle encourager le dopage? L'ideal de l'ingenieur en biomedecine
      et la question de l'amelioration de l'humain.
PL  - Belgium
TA  - Bull Mem Acad R Med Belg
JT  - Bulletin et memoires de l'Academie royale de medecine de Belgique
JID - 7608462
SB  - IM
MH  - Abortion, Eugenic/ethics/trends
MH  - Biomedical Engineering/*ethics/*trends
MH  - Biomedical Enhancement/*ethics
MH  - Female
MH  - Forecasting
MH  - Humans
MH  - Pregnancy
MH  - Quality of Life
EDAT- 2011/01/01 00:00
MHDA- 2012/03/15 06:00
CRDT- 2012/03/02 06:00
PHST- 2012/03/02 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2012/03/15 06:00 [medline]
PST - ppublish
SO  - Bull Mem Acad R Med Belg. 2011;166(1-2):49-58; discussion 59-61.


PMID- 22375349
OWN - NLM
STAT- MEDLINE
DCOM- 20120321
LR  - 20191112
IS  - 0030-2228 (Print)
IS  - 0030-2228 (Linking)
VI  - 64
IP  - 2
DP  - 2011-2012
TI  - The importance of end-of-life care in nursing home settings is not diminished by 
      a disaster.
PG  - 143-55
AB  - The emphasis in disaster situations is on preserving life, and this goal is both 
      appropriate and laudable. There is a risk, however, that the needs of people who 
      are dying can become lost when there is a sudden surge of people needing acute
      intervention. There are significant ethical considerations inherent in society's 
      prioritization of care needs across the acute, rehabilitative, and palliative
      spectrum in general, let alone in a disaster situation. These ethical conundrums 
      are not the focus of this article. Rather, we anchor our discussion on the
      assumption that care needs are equally valid, and our purpose is to explore the
      issues that impact the provision of quality end-of-life care in nursing home
      settings for those who require this care when a disaster occurs. Nursing home
      residents, in particular, are at heightened risk for experiencing negative
      disaster-related outcomes due to compromised physical or mental health that
      requires skilled nursing care. Moreover, within the already vulnerable nursing
      home population are many people who are receiving palliative end-of-life services
      when a disaster strikes. Education and training in end-of-life services for
      nursing home staff, disaster emergency responders, and other lay people is vital 
      to build capacity for adapting the delivery of these services in disaster
      situations in the interest of equity and human rights. Given the present lack of 
      guidance in the literature as to what end-of-life care looks like when adapted to
      the context of disaster response, there is also a pressing need for research to
      inform this discussion. The purpose of this article is to draw attention to this 
      topic and highlight some of the critical issues, gaps, and opportunities.
FAU - Frahm, Kathryn A
AU  - Frahm KA
AD  - Department of Aging and Mental Health Disparities, University of South Florida,
      Tampa 33612, USA. kfrahm@usf.edu
FAU - Brown, Lisa M
AU  - Brown LM
FAU - Gibson, Maggie
AU  - Gibson M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Omega (Westport)
JT  - Omega
JID - 1272106
SB  - IM
MH  - Attitude of Health Personnel
MH  - Disaster Planning/*organization & administration
MH  - Home Nursing/*organization & administration
MH  - Humans
MH  - Nursing Staff/organization & administration
MH  - Palliative Care/*organization & administration
MH  - Professional Competence
MH  - Professional Role
MH  - Professional-Family Relations
MH  - *Quality Indicators, Health Care
MH  - Rescue Work/organization & administration
MH  - Security Measures/*organization & administration
MH  - Terminal Care/*organization & administration
EDAT- 2011/01/01 00:00
MHDA- 2012/03/22 06:00
CRDT- 2012/03/02 06:00
PHST- 2012/03/02 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2012/03/22 06:00 [medline]
AID - 10.2190/om.64.2.c [doi]
PST - ppublish
SO  - Omega (Westport). 2011-2012;64(2):143-55. doi: 10.2190/om.64.2.c.


PMID- 21191850
OWN - NLM
STAT- MEDLINE
DCOM- 20110414
LR  - 20101230
IS  - 1520-5711 (Electronic)
IS  - 1054-3406 (Linking)
VI  - 21
IP  - 1
DP  - 2011 Jan
TI  - Sample size determination for testing equality in a cluster randomized trial with
      noncompliance.
PG  - 1-17
LID - 10.1080/10543400903350465 [doi]
AB  - For administrative convenience or cost efficiency, we may often employ a cluster 
      randomized trial (CRT), in which randomized units are clusters of patients rather
      than individual patients. Furthermore, because of ethical reasons or patient's
      decision, it is not uncommon to encounter data in which there are patients not
      complying with their assigned treatments. Thus, the development of a sample size 
      calculation procedure for a CRT with noncompliance is important and useful in
      practice. Under the exclusion restriction model, we have developed an asymptotic 
      test procedure using a tanh(-1)(x) transformation for testing equality between
      two treatments among compliers for a CRT with noncompliance. We have further
      derived a sample size formula accounting for both noncompliance and the
      intraclass correlation for a desired power 1 - beta at a nominal alpha level. We 
      have employed Monte Carlo simulation to evaluate the finite-sample performance of
      the proposed test procedure with respect to type I error and the accuracy of the 
      derived sample size calculation formula with respect to power in a variety of
      situations. Finally, we use the data taken from a CRT studying vitamin A
      supplementation to reduce mortality among preschool children to illustrate the
      use of sample size calculation proposed here.
FAU - Lui, Kung-Jong
AU  - Lui KJ
AD  - Mathematics and Statistics, San Diego State University, San Diego, CA 92182-7720,
      USA. kjl@rohan.sdsu.edu
FAU - Chang, Kuang-Chao
AU  - Chang KC
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Biopharm Stat
JT  - Journal of biopharmaceutical statistics
JID - 9200436
RN  - 0 (Vitamins)
RN  - 11103-57-4 (Vitamin A)
SB  - IM
MH  - Child Mortality
MH  - Child, Preschool
MH  - Cluster Analysis
MH  - Humans
MH  - *Models, Statistical
MH  - Monte Carlo Method
MH  - *Patient Compliance
MH  - Randomized Controlled Trials as Topic/*methods
MH  - Research Design
MH  - Sample Size
MH  - Vitamin A/*administration & dosage/therapeutic use
MH  - Vitamins/*administration & dosage/therapeutic use
EDAT- 2010/12/31 06:00
MHDA- 2011/04/16 06:00
CRDT- 2010/12/31 06:00
PHST- 2010/12/31 06:00 [entrez]
PHST- 2010/12/31 06:00 [pubmed]
PHST- 2011/04/16 06:00 [medline]
AID - 931672405 [pii]
AID - 10.1080/10543400903350465 [doi]
PST - ppublish
SO  - J Biopharm Stat. 2011 Jan;21(1):1-17. doi: 10.1080/10543400903350465.


PMID- 21190537
OWN - NLM
STAT- MEDLINE
DCOM- 20110927
LR  - 20191111
IS  - 2212-3946 (Electronic)
IS  - 1574-888X (Linking)
VI  - 6
IP  - 2
DP  - 2011 Jun
TI  - Current status and prospective application of stem cell-based therapies for
      spinal cord injury.
PG  - 93-104
AB  - Spinal cord injuries (SCIs) are a common form of trauma that leaves a huge trail 
      of morbidity and human suffering in its wake. They occur mostly among the young, 
      causing severe physical, psychological, social and economic burdens. The
      treatment of this condition has rather been disappointing; most of the management
      strategies being mainly supportive and prophylactic. In recent years there has
      been an emerging interest in the use of stem cells to regenerate the nervous
      tissue that has been damaged or lost. Although there has been much hype and
      unfounded hope, modest successes have been witnessed, and it is possible that
      these therapeutic strategies may have much more to offer in the future. This
      paper will review the current strategies of exploring cell-based therapies,
      mainly different types of stem cells to treat SCI along with the evidence that
      has been accumulated over the past decade in a rational bench-to-bedside
      approach. Furthermore, critical aspects such as the mode of delivery and ethical 
      considerations are also discussed along with feasible suggestions for future
      translational research to provide a contextual picture of the current state of
      advancements in this field. The impediments to regeneration in the site of injury
      are briefly explained along with the benefits and drawbacks of different cell
      types used in the treatment of this condition. We hope that this review will
      offer a significant insight into this challenging clinical condition.
FAU - Das, Anjan Kumar
AU  - Das AK
AD  - Stempeutics Research Malaysia Sdn. Bhd., Technology Park Malaysia, Kuala Lumpur
      57000, Malaysia. anjan.das@stempeutics.com.my
FAU - Gopurappilly, Renjitha
AU  - Gopurappilly R
FAU - Parhar, Ishwar
AU  - Parhar I
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Stem Cell Res Ther
JT  - Current stem cell research & therapy
JID - 101272517
SB  - IM
MH  - Animals
MH  - Humans
MH  - Nerve Regeneration/*physiology
MH  - Spinal Cord Injuries/*therapy
MH  - *Stem Cell Transplantation
MH  - Stem Cells/*cytology/*physiology
EDAT- 2010/12/31 06:00
MHDA- 2011/09/29 06:00
CRDT- 2010/12/31 06:00
PHST- 2009/12/08 00:00 [received]
PHST- 2010/07/21 00:00 [accepted]
PHST- 2010/12/31 06:00 [entrez]
PHST- 2010/12/31 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - BSP/CSCRT/E-Pub/00081 [pii]
AID - 10.2174/157488811795495477 [doi]
PST - ppublish
SO  - Curr Stem Cell Res Ther. 2011 Jun;6(2):93-104. doi: 10.2174/157488811795495477.


PMID- 21190410
OWN - NLM
STAT- MEDLINE
DCOM- 20110411
LR  - 20220410
IS  - 1532-2491 (Electronic)
IS  - 1082-6084 (Linking)
VI  - 46
IP  - 1
DP  - 2011
TI  - Explicating an evidence-based, theoretically informed, mobile technology-based
      system to improve outcomes for people in recovery for alcohol dependence.
PG  - 96-111
LID - 10.3109/10826084.2011.521413 [doi]
AB  - Post-treatment relapse to uncontrolled alcohol use is common. Currently available
      communication technology can use existing models for relapse prevention to
      cost-effectively improve long-term relapse prevention. This paper describes: (1) 
      research-based elements of alcohol consumption-related relapse prevention and how
      they can be encompassed in self-determination theory (SDT) and Marlatt's
      cognitive behavioral relapse prevention model, (2) how technology could help
      address the needs of people seeking recovery, (3) a technology-based prototype,
      organized around sexual transmitted disease and Marlatt's model, and (4) how we
      are testing a system based on the ideas in this article and related ethical and
      operational considerations.
FAU - Gustafson, David H
AU  - Gustafson DH
AD  - Network for the Improvement of Addiction Treatment, University of
      Wisconsin-Madison, Madison, WI 53706, USA.
FAU - Shaw, Bret R
AU  - Shaw BR
FAU - Isham, Andrew
AU  - Isham A
FAU - Baker, Timothy
AU  - Baker T
FAU - Boyle, Michael G
AU  - Boyle MG
FAU - Levy, Michael
AU  - Levy M
LA  - eng
GR  - R01 AA017192/AA/NIAAA NIH HHS/United States
GR  - R01 AA017192-02/AA/NIAAA NIH HHS/United States
GR  - R01 AA017192-03/AA/NIAAA NIH HHS/United States
GR  - R01 AA017192-04/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Subst Use Misuse
JT  - Substance use & misuse
JID - 9602153
SB  - IM
MH  - Adaptation, Psychological
MH  - Alcoholism/psychology/*therapy
MH  - *Cell Phone
MH  - Cognition
MH  - *Computers, Handheld
MH  - Counseling/*methods
MH  - Evidence-Based Practice
MH  - Health Promotion/*methods
MH  - Humans
MH  - Medical Informatics Applications
MH  - National Cancer Institute (U.S.)
MH  - Program Development
MH  - Randomized Controlled Trials as Topic
MH  - *Secondary Prevention
MH  - Sexually Transmitted Diseases
MH  - Social Support
MH  - Treatment Outcome
MH  - United States
PMC - PMC3179272
MID - NIHMS317050
EDAT- 2010/12/31 06:00
MHDA- 2011/04/13 06:00
CRDT- 2010/12/31 06:00
PHST- 2010/12/31 06:00 [entrez]
PHST- 2010/12/31 06:00 [pubmed]
PHST- 2011/04/13 06:00 [medline]
AID - 10.3109/10826084.2011.521413 [doi]
PST - ppublish
SO  - Subst Use Misuse. 2011;46(1):96-111. doi: 10.3109/10826084.2011.521413.


PMID- 21190068
OWN - NLM
STAT- MEDLINE
DCOM- 20110620
LR  - 20211020
IS  - 1573-076X (Electronic)
IS  - 0165-005X (Linking)
VI  - 35
IP  - 1
DP  - 2011 Mar
TI  - Millennial medical anthropology: from there to here and beyond, or the problem of
      global health.
PG  - 83-9
LID - 10.1007/s11013-010-9203-x [doi]
AB  - While much of Medical Anthropology was and is what we can call "Normal"
      (following Kuhn) Medical Anthropology, I coined the term Millennial Medical
      Anthropology for that branch of the discipline that, in the 1990s, was departing 
      from the Normal research paradigms and was deserving of a distinct sobriquet.
      This paper considers the Strong Program in Medical Anthropology's Millennial
      Medical Anthropology and its key subdivisions, the Cultural Studies of Science
      and Cultural Bioethics. Specifically it considers Medical Anthropology's movement
      from the past into an ethical future wherein Normal Biomedicine, Bioethics and
      Global Health are problematized. This provides the basis for the construction of 
      a truly anthropological global health (i.e., Global, Global Health or Global
      Health 2.0).
FAU - Gaines, Atwood D
AU  - Gaines AD
AD  - Case Western Reserve University, Cleveland, OH 44106, USA. atwood.gaines@case.edu
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Cult Med Psychiatry
JT  - Culture, medicine and psychiatry
JID - 7707467
SB  - IM
MH  - *Anthropology, Physical
MH  - Bioethics
MH  - *Global Health
MH  - Humans
EDAT- 2010/12/31 06:00
MHDA- 2011/06/21 06:00
CRDT- 2010/12/31 06:00
PHST- 2010/12/31 06:00 [entrez]
PHST- 2010/12/31 06:00 [pubmed]
PHST- 2011/06/21 06:00 [medline]
AID - 10.1007/s11013-010-9203-x [doi]
PST - ppublish
SO  - Cult Med Psychiatry. 2011 Mar;35(1):83-9. doi: 10.1007/s11013-010-9203-x.


PMID- 21188655
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20211020
IS  - 2629-3277 (Electronic)
IS  - 2629-3277 (Linking)
VI  - 7
IP  - 3
DP  - 2011 Sep
TI  - Development of feeder-free culture systems for generation of ckit+sca1+
      progenitors from mouse iPS cells.
PG  - 736-47
LID - 10.1007/s12015-010-9215-5 [doi]
AB  - Patient-specific therapeutic cells derived from induced pluripotent stem (iPS)
      cells may bypass the ethical issues associated with embryonic stem (ES) cells and
      avoid potential immunological reactions associated with allogenic
      transplantation. It is critical, for the ultimate clinical applicability of iPS
      cell-derived therapies, to establish feeder-free cultures that ensure efficient
      differentiation of iPS cells into therapeutic progenitors. It is also necessary
      to understand if iPS cell-derived progenitors differ from those derived from ES
      cells. In this study, we compared the efficiency of three different feeder-free
      cultures for differentiating mouse iPS cells into ckit+sca1+ hematopoietic
      progenitor cells (HPCs) and compared how differentiation and functionality varies
      between ES and iPS cells. Our results indicated that both iPS and ES cells can be
      efficiently differentiated into HPCs in suspension cultures supplemented with
      secretion factors from mouse bone marrow stromal cells (OP9-DL1 conditioned
      medium). The functionality of these cells was demonstrated by differentiation
      into CD11c+ dendritic cells (DCs). Both ES and iPS-derived DCs expressed
      activation molecules (CD86, CD80) in response to LPS stimulation and stimulated T
      cell proliferation in a mixed lymphocyte reaction (MLR). Extensive quantitative
      RT-PCR studies were used to study the differences in gene expression profiles of 
      ckit+sca1+ cells generated from the various culture systems as well as
      differences between ES-derived and iPS-derived cells. We conclude that a
      feeder-free system using stromal conditioned medium can efficiently generate HPCs
      as well as functional DCs from iPS cells and the generated cells have similar
      gene expression profile as those from ES cells.
FAU - Lin, Jian
AU  - Lin J
AD  - Department of Biomedical Engineering, The University of Texas at Austin, Austin, 
      TX 78712, USA.
FAU - Fernandez, Irina
AU  - Fernandez I
FAU - Roy, Krishnendu
AU  - Roy K
LA  - eng
GR  - R01 EB005026-01A2/EB/NIBIB NIH HHS/United States
GR  - R01 EB005026-02/EB/NIBIB NIH HHS/United States
GR  - EB005026/EB/NIBIB NIH HHS/United States
GR  - R01 EB005026-04/EB/NIBIB NIH HHS/United States
GR  - R01 EB005026/EB/NIBIB NIH HHS/United States
GR  - R01 EB005026-03/EB/NIBIB NIH HHS/United States
GR  - R01 EB005026-03S1/EB/NIBIB NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Stem Cell Rev Rep
JT  - Stem cell reviews and reports
JID - 101752767
RN  - 0 (Antigens, Ly)
RN  - 0 (Biomarkers)
RN  - 0 (Culture Media, Conditioned)
RN  - 0 (Ly6a protein, mouse)
RN  - 0 (Membrane Proteins)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-kit)
SB  - IM
MH  - Animals
MH  - Antigens, Ly/*metabolism
MH  - Biomarkers/metabolism
MH  - Cell Culture Techniques/*methods
MH  - Cell Differentiation/*physiology
MH  - Cells, Cultured
MH  - Culture Media, Conditioned/metabolism
MH  - Dendritic Cells/cytology/physiology
MH  - Gene Expression Profiling
MH  - Humans
MH  - Induced Pluripotent Stem Cells/cytology/*physiology
MH  - Membrane Proteins/*metabolism
MH  - Mice
MH  - Proto-Oncogene Proteins c-kit/*metabolism
MH  - Stem Cells/cytology/*physiology
PMC - PMC3302179
MID - NIHMS280387
EDAT- 2010/12/29 06:00
MHDA- 2011/11/16 06:00
CRDT- 2010/12/29 06:00
PHST- 2010/12/29 06:00 [entrez]
PHST- 2010/12/29 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - 10.1007/s12015-010-9215-5 [doi]
PST - ppublish
SO  - Stem Cell Rev Rep. 2011 Sep;7(3):736-47. doi: 10.1007/s12015-010-9215-5.


PMID- 21188653
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20211020
IS  - 2629-3277 (Electronic)
IS  - 2629-3277 (Linking)
VI  - 7
IP  - 3
DP  - 2011 Sep
TI  - Influence of E-cadherin-mediated cell adhesion on mouse embryonic stem cells
      derivation from isolated blastomeres.
PG  - 494-505
LID - 10.1007/s12015-010-9221-7 [doi]
AB  - Efforts to efficiently derive embryonic stem cells (ESC) from isolated
      blastomeres have been done to minimize ethical concerns about human embryo
      destruction. Previous studies in our laboratory indicated a poor derivation
      efficiency of mouse ESC lines from isolated blastomeres at the 8-cell stage (1/8 
      blastomeres) due, in part, to a low division rate of the single blastomeres in
      comparison to their counterparts with a higher number of blastomeres (2/8, 3/8
      and 4/8 blastomeres). Communication and adhesion between blastomeres from which
      the derivation process begins could be important aspects to efficiently derive
      ESC lines. In the present study, an approach consisting in the adhesion of a
      chimeric E-cadherin (E-cad-Fc) to the blastomere surface was devised to recreate 
      the signaling produced by native E-cadherin between neighboring blastomeres
      inside the embryo. By this approach, the division rate of 1/8 blastomeres
      increased from 44.6% to 88.8% and a short exposure of 24 h to the E-cad-Fc
      produced an ESC derivation efficiency of 33.6%, significantly higher than the
      2.2% obtained from the control group without E-cad-Fc. By contrast, a longer
      exposure to the same chimeric protein resulted in higher proportions of
      trophoblastic vesicles. Thus, we establish an important role of
      E-cadherin-mediated adherens junctions in promoting both the division of single
      1/8 blastomeres and the efficiency of the ESC derivation process.
FAU - Gonzalez, Sheyla
AU  - Gonzalez S
AD  - Departament de Biologia Cel.lular, Fisiologia i Immunologia, Facultat de
      Biociencies, Universitat Autonoma de Barcelona, 08193, Bellaterra, Spain.
      Sheyla.Gonzalez@uab.cat
FAU - Ibanez, Elena
AU  - Ibanez E
FAU - Santalo, Josep
AU  - Santalo J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Stem Cell Rev Rep
JT  - Stem cell reviews and reports
JID - 101752767
RN  - 0 (Biomarkers)
RN  - 0 (Cadherins)
RN  - 0 (Recombinant Fusion Proteins)
SB  - IM
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Blastomeres/*cytology/physiology
MH  - Cadherins/genetics/*metabolism
MH  - Cell Adhesion/*physiology
MH  - Cell Culture Techniques/methods
MH  - Cell Differentiation/physiology
MH  - Cell Division/physiology
MH  - Cell Line
MH  - Embryonic Stem Cells/cytology/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Recombinant Fusion Proteins/genetics/metabolism
EDAT- 2010/12/29 06:00
MHDA- 2011/11/16 06:00
CRDT- 2010/12/29 06:00
PHST- 2010/12/29 06:00 [entrez]
PHST- 2010/12/29 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - 10.1007/s12015-010-9221-7 [doi]
PST - ppublish
SO  - Stem Cell Rev Rep. 2011 Sep;7(3):494-505. doi: 10.1007/s12015-010-9221-7.


PMID- 21188473
OWN - NLM
STAT- MEDLINE
DCOM- 20110819
LR  - 20211020
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 23
IP  - 1
DP  - 2011 Mar
TI  - Bioethics on the subcontinent: the Sindh Institute in Karachi.
PG  - 57-61
LID - 10.1007/s10730-010-9143-4 [doi]
AB  - In this personal narrative the author recounts his experiences teaching bioethics
      in Pakistan. He notes the different moral, cultural and legal environments of
      Pakistan as compared to the United States, and in particular, the ways in which
      subtle interpretations of Sharia law shape bioethical reflections as well as the 
      biomedical legal environment. As he argues, any attempt to export models of
      bioethics from one country to another with no attention to social and cultural
      differences is a recipe for failure. To presume that all ethical considerations
      are universal is to devalue moral traditions that differ from our own, and
      dismiss cultural values of other societies.
FAU - Lombardo, Paul A
AU  - Lombardo PA
AD  - Center for Health, Law & Society, College of Law, Georgia State University,
      Atlanta, 30302-4037, USA. plombardo@gsu.edu
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - Abortion, Induced/ethics
MH  - *Bioethics
MH  - Humans
MH  - Internationality
MH  - Islam
MH  - Pakistan
MH  - Religion and Medicine
EDAT- 2010/12/29 06:00
MHDA- 2011/08/20 06:00
CRDT- 2010/12/29 06:00
PHST- 2010/12/29 06:00 [entrez]
PHST- 2010/12/29 06:00 [pubmed]
PHST- 2011/08/20 06:00 [medline]
AID - 10.1007/s10730-010-9143-4 [doi]
PST - ppublish
SO  - HEC Forum. 2011 Mar;23(1):57-61. doi: 10.1007/s10730-010-9143-4.


PMID- 21185995
OWN - NLM
STAT- MEDLINE
DCOM- 20110304
LR  - 20101227
IS  - 1878-4321 (Electronic)
IS  - 1049-3867 (Linking)
VI  - 21
IP  - 1
DP  - 2011 Jan-Feb
TI  - The Suleman octuplet case and egregious ethical breaches.
PG  - 98
LID - 10.1016/j.whi.2010.11.004 [doi]
FAU - Rosenthal, M Sara
AU  - Rosenthal MS
LA  - eng
PT  - Letter
PL  - United States
TA  - Womens Health Issues
JT  - Women's health issues : official publication of the Jacobs Institute of Women's
      Health
JID - 9101000
SB  - IM
MH  - California
MH  - *Ethics, Medical
MH  - Female
MH  - Fertilization in Vitro/*ethics
MH  - Humans
MH  - Multiple Birth Offspring
MH  - Pregnancy
MH  - *Pregnancy, Multiple
EDAT- 2010/12/28 06:00
MHDA- 2011/03/05 06:00
CRDT- 2010/12/28 06:00
PHST- 2010/11/01 00:00 [received]
PHST- 2010/11/06 00:00 [accepted]
PHST- 2010/12/28 06:00 [entrez]
PHST- 2010/12/28 06:00 [pubmed]
PHST- 2011/03/05 06:00 [medline]
AID - S1049-3867(10)00153-2 [pii]
AID - 10.1016/j.whi.2010.11.004 [doi]
PST - ppublish
SO  - Womens Health Issues. 2011 Jan-Feb;21(1):98. doi: 10.1016/j.whi.2010.11.004.


PMID- 21184921
OWN - NLM
STAT- MEDLINE
DCOM- 20110125
LR  - 20101227
IS  - 1523-6838 (Electronic)
IS  - 0272-6386 (Linking)
VI  - 57
IP  - 1
DP  - 2011 Jan
TI  - Kidney paired donation: fundamentals, limitations, and expansions.
PG  - 144-51
LID - 10.1053/j.ajkd.2010.10.005 [doi]
AB  - Incompatibility between the candidate recipient and the prospective donor is a
      major obstacle to living donor kidney transplant. Kidney paired donation (KPD)
      can circumvent the incompatibility by matching them to another candidate and
      living donor for an exchange of transplants such that both transplants are
      compatible. KPD has faced legal, logistical, and ethical challenges since its
      inception in the 1980s. Although the full potential of this modality for
      facilitating transplant for individuals with incompatible donors is unrealized,
      great strides have been made. In this review article, we detail how several
      impediments to KPD have been overcome to the benefit of ever greater numbers of
      patients. Limitations and questions that have been addressed include blood group 
      type O imbalance, reciprocal match requirements, simultaneous donor nephrectomy
      requirements, combining KPD with desensitization, the role of list-paired
      donation, geographic barriers, legal barriers, concerns regarding living donor
      safety, fragmented registries, and inefficient matching algorithms.
CI  - Copyright (c) 2010 National Kidney Foundation, Inc. All rights reserved.
FAU - Gentry, Sommer E
AU  - Gentry SE
AD  - Department of Mathematics, US Naval Academy, Annapolis, MD, USA.
FAU - Montgomery, Robert A
AU  - Montgomery RA
FAU - Segev, Dorry L
AU  - Segev DL
LA  - eng
GR  - RC1DK086731/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Am J Kidney Dis
JT  - American journal of kidney diseases : the official journal of the National Kidney
      Foundation
JID - 8110075
SB  - IM
MH  - Desensitization, Immunologic
MH  - Directed Tissue Donation/legislation & jurisprudence
MH  - Health Services Accessibility
MH  - Histocompatibility
MH  - Humans
MH  - *Kidney Transplantation/immunology/legislation & jurisprudence
MH  - *Living Donors/legislation & jurisprudence
MH  - *Tissue and Organ Procurement
MH  - United States
MH  - Waiting Lists
EDAT- 2010/12/28 06:00
MHDA- 2011/01/28 06:00
CRDT- 2010/12/28 06:00
PHST- 2010/04/28 00:00 [received]
PHST- 2010/10/07 00:00 [accepted]
PHST- 2010/12/28 06:00 [entrez]
PHST- 2010/12/28 06:00 [pubmed]
PHST- 2011/01/28 06:00 [medline]
AID - S0272-6386(10)01439-3 [pii]
AID - 10.1053/j.ajkd.2010.10.005 [doi]
PST - ppublish
SO  - Am J Kidney Dis. 2011 Jan;57(1):144-51. doi: 10.1053/j.ajkd.2010.10.005.


PMID- 21184283
OWN - NLM
STAT- MEDLINE
DCOM- 20110829
LR  - 20211020
IS  - 1573-6571 (Electronic)
IS  - 0022-4197 (Linking)
VI  - 50
IP  - 2
DP  - 2011 Jun
TI  - An ethic of resistance: choosing life in health messages for African American
      women.
PG  - 219-31
LID - 10.1007/s10943-010-9434-8 [doi]
AB  - Media messages directed to African American women are more likely to have health 
      content that emphasizes negative outcomes or sexual stereotypes. This paper
      critiques the use of health messages that focus on high mortality and morbidity
      rates, yet have not reduced health disparities, but have instead reduced Black
      women's bodies to carriers of disease. I introduce an ethic of resistance that
      privileges the authority and wholeness of Black women rather than disease and
      fragmentation. An ethic of resistance helps Black women connect to their
      spiritual health, move from passive receiver to active resister of negative
      messages, and break the generational silence to demystify sexuality and integrate
      it into a lifestyle of wholeness. My hope is to improve the health outcomes of
      African American women by improving the message.
FAU - Davis-Carroll, Hilda R
AU  - Davis-Carroll HR
AD  - Pastoral Counseling Centers of Tennessee, P.O. Box 282471, Nashville, TN 37228,
      USA. hrdaviscarroll@aol.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Relig Health
JT  - Journal of religion and health
JID - 2985199R
SB  - IM
MH  - Adult
MH  - African Americans/*psychology
MH  - Attitude to Death/*ethnology
MH  - Attitude to Health/ethnology
MH  - *Choice Behavior
MH  - Female
MH  - HIV Infections/mortality
MH  - *Health Promotion
MH  - Health Status Disparities
MH  - Humans
MH  - *Persuasive Communication
MH  - Self Concept
MH  - Sexually Transmitted Diseases
MH  - Spirituality
MH  - Stereotyping
MH  - United States/epidemiology
EDAT- 2010/12/25 06:00
MHDA- 2011/08/30 06:00
CRDT- 2010/12/25 06:00
PHST- 2010/12/25 06:00 [entrez]
PHST- 2010/12/25 06:00 [pubmed]
PHST- 2011/08/30 06:00 [medline]
AID - 10.1007/s10943-010-9434-8 [doi]
PST - ppublish
SO  - J Relig Health. 2011 Jun;50(2):219-31. doi: 10.1007/s10943-010-9434-8.


PMID- 21182477
OWN - NLM
STAT- MEDLINE
DCOM- 20110617
LR  - 20190823
IS  - 1875-533X (Electronic)
IS  - 0929-8673 (Linking)
VI  - 18
IP  - 6
DP  - 2011
TI  - Comparison of status epilepticus models induced by pilocarpine and nerve agents -
      a systematic review of the underlying aetiology and adopted therapeutic
      approaches.
PG  - 886-99
AB  - Among potential radiological, nuclear, biological and chemical weapons,
      cholinergic nerve agents from chemical weapons remain a realistic terrorist
      threat due to its combination of high lethality, demonstrated use and relative
      abundance of un-destroyed stockpiles in various militaries around the world.
      While current fielded antidotes are able to mitigate acute poisoning, effective
      neuroprotection in the field remains a challenge amongst subjects with
      established status epilepticus following nerve agent intoxication. Due to
      ethical, safety and surety issues, extensive preclinical and clinical research on
      cholinergic nerve agents is not possible. This may have been a contributory
      factor for the slow progress in uncovering new neuroprotectants for nerve agent
      casualties with established status epilepticus. To overcome this challenge,
      comparative research with surrogate chemicals that produce similar
      hypercholinergic toxicity but with less security concerns would be a useful
      approach forward. In this paper, we will systemically compare the mechanism of
      seizure generation, propagation and the subsequent clinical, hematologic, and
      metabolic, biochemical, neuroinflammatory changes and current therapeutic
      approaches reported in pilocarpine, soman, and sarin models of seizures. This
      review will be an important first step in closing this knowledge gap among
      different closely related models of seizures and neurotoxicity. Hopefully, it
      will spur further efforts in using surrogate cholinergic models by the wider
      scientific community to expedite the development of a new generation of antidotes
      that are better able to protect against delayed neurological effects inflicted by
      nerve agents.
FAU - Tang, F R
AU  - Tang FR
AD  - Temasek Laboratories, National University of Singapore, Singapore.
      tangfr@gmail.com
FAU - Loke, W K
AU  - Loke WK
FAU - Ling, E A
AU  - Ling EA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
PT  - Systematic Review
PL  - United Arab Emirates
TA  - Curr Med Chem
JT  - Current medicinal chemistry
JID - 9440157
RN  - 0 (Chemical Warfare Agents)
RN  - 01MI4Q9DI3 (Pilocarpine)
RN  - 96-64-0 (Soman)
RN  - B4XG72QGFM (Sarin)
SB  - IM
MH  - Animals
MH  - Brain/drug effects/metabolism
MH  - Chemical Warfare Agents/*pharmacology/toxicity
MH  - Humans
MH  - Pilocarpine/*pharmacology/toxicity
MH  - Sarin/pharmacology/toxicity
MH  - Soman/pharmacology/toxicity
MH  - Status Epilepticus/*chemically induced/etiology/metabolism/*therapy
EDAT- 2010/12/25 06:00
MHDA- 2011/06/18 06:00
CRDT- 2010/12/25 06:00
PHST- 2010/10/29 00:00 [received]
PHST- 2010/12/30 00:00 [accepted]
PHST- 2010/12/25 06:00 [entrez]
PHST- 2010/12/25 06:00 [pubmed]
PHST- 2011/06/18 06:00 [medline]
AID - BSP/CMC/E-Pub/2011/ 051 [pii]
AID - 10.2174/092986711794927720 [doi]
PST - ppublish
SO  - Curr Med Chem. 2011;18(6):886-99. doi: 10.2174/092986711794927720.


PMID- 21182374
OWN - NLM
STAT- MEDLINE
DCOM- 20110422
LR  - 20101224
IS  - 1466-187X (Electronic)
IS  - 0142-159X (Linking)
VI  - 33
IP  - 1
DP  - 2011
TI  - The ethics of HIV testing and disclosure for healthcare professionals: what do
      our future doctors think?
PG  - e50-6
LID - 10.3109/0142159X.2011.530311 [doi]
AB  - AIM: This study examined future medical professionals' attitudes and beliefs
      regarding mandatory human immunodeficiency virus (HIV) testing and disclosure.
      METHOD: A total of 54 US medical students were interviewed regarding mandatory
      testing and disclosure of HIV status for both patient and health care
      professional populations. Interviews were qualitatively analyzed using thematic
      analysis by the first author and verified by the second author. RESULTS: Medical 
      students considered a variety of perspectives, even placing themselves in the
      shoes of their patients or imagining themselves as a healthcare professional with
      HIV. Mixed opinions were presented regarding the importance of HIV testing for
      students coupled with a fear about school administration regarding HIV positive
      test results and the outcome of a student's career. Third- and fourth-year
      medical students felt that there should be no obligation to disclose one's HIV
      status to patients, colleagues, or employers. However, most of these students did
      feel that patients had an obligation to disclose their HIV status to healthcare
      professionals. CONCLUSION: This study gives medical educators a glimpse into what
      our future doctors think about HIV testing and disclosure, and how difficult it
      is for them to recognize that they can be patients too, as they are conflicted by
      professional and personal values.
FAU - Aultman, Julie M
AU  - Aultman JM
AD  - Department of Behavioral and Community Health Sciences, Northeastern Ohio
      Universities College of Medicine, Rootstown, OH 44272-0095, USA.
      jmaultma@neoucom.edu
FAU - Borges, Nicole J
AU  - Borges NJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - Med Teach
JT  - Medical teacher
JID - 7909593
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anonymous Testing/ethics
MH  - Disclosure/*ethics
MH  - Female
MH  - HIV Seropositivity/*diagnosis
MH  - Health Care Surveys
MH  - Humans
MH  - Male
MH  - Students, Medical/*psychology
MH  - Young Adult
EDAT- 2010/12/25 06:00
MHDA- 2011/04/26 06:00
CRDT- 2010/12/25 06:00
PHST- 2010/12/25 06:00 [entrez]
PHST- 2010/12/25 06:00 [pubmed]
PHST- 2011/04/26 06:00 [medline]
AID - 10.3109/0142159X.2011.530311 [doi]
PST - ppublish
SO  - Med Teach. 2011;33(1):e50-6. doi: 10.3109/0142159X.2011.530311.


PMID- 21182373
OWN - NLM
STAT- MEDLINE
DCOM- 20110422
LR  - 20101224
IS  - 1466-187X (Electronic)
IS  - 0142-159X (Linking)
VI  - 33
IP  - 1
DP  - 2011
TI  - The ethical and pedagogical effects of modeling "not-so-universal" precautions.
PG  - e43-9
LID - 10.3109/0142159X.2011.530310 [doi]
AB  - AIM: We sought to understand current medical students' levels of training and
      knowledge, and their attitudes regarding universal precautions practices and
      underlying professional and ethical issues. METHOD: A total of 54 US medical
      students at two schools were interviewed to determine the level of understanding 
      and training students receive about universal precautions, their feelings about
      the effectiveness (or ineffectiveness) of universal precautions, the frequency
      and kinds of universal precautions used by healthcare professionals as observed
      by medical students, and students' perspectives about the lack of or inconsistent
      use of universal precautions. RESULTS: Pre-clinical students focused on safe-sex 
      practices among students and professionals, as well as simple, important acts to 
      protect oneself against infection and disease, such as hand-washing. Clinical
      students, on the other hand, had more exposure to observing and practicing
      universal precautions, thus presented us with more, in-depth responses pertaining
      to inconsistent and ineffective use of universal precautions among peers and role
      models. Several themes were noted from students' responses. CONCLUSION: This
      study confirms previously acquired data that universal precautions are not
      consistently or appropriately used by healthcare professionals, it is a
      significant and novel study in that it reveals a hidden, ethical, and clinical
      problem in medical education.
FAU - Aultman, Julie M
AU  - Aultman JM
AD  - Northeastern Ohio Universities College of Medicine and Pharmacy, Rootstown, OH
      44272-0095, USA. jmaultma@neoucom.edu
FAU - Borges, Nicole J
AU  - Borges NJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - Med Teach
JT  - Medical teacher
JID - 7909593
SB  - IM
MH  - Adolescent
MH  - *Ethics, Professional
MH  - Female
MH  - Focus Groups
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Male
MH  - *Models, Organizational
MH  - Students, Medical/psychology
MH  - United States
MH  - *Universal Precautions
MH  - Young Adult
EDAT- 2010/12/25 06:00
MHDA- 2011/04/26 06:00
CRDT- 2010/12/25 06:00
PHST- 2010/12/25 06:00 [entrez]
PHST- 2010/12/25 06:00 [pubmed]
PHST- 2011/04/26 06:00 [medline]
AID - 10.3109/0142159X.2011.530310 [doi]
PST - ppublish
SO  - Med Teach. 2011;33(1):e43-9. doi: 10.3109/0142159X.2011.530310.


PMID- 21181306
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20211020
IS  - 2629-3277 (Electronic)
IS  - 2629-3277 (Linking)
VI  - 7
IP  - 3
DP  - 2011 Sep
TI  - Characterization of a novel umbilical cord lining cell with CD227 positivity and 
      unique pattern of P63 expression and function.
PG  - 624-38
LID - 10.1007/s12015-010-9214-6 [doi]
AB  - Umbilical cord tissue is gaining attention as a novel source of multipotent stem 
      cells because it is easily obtainable, ethically acceptable and the cells are
      immunologically naive. In this study, we have isolated and characterized a new
      cell type expressing MUCIN1 (CD227) from human umbilical cord lining which we
      termed MUCIN-expressing Cord Lining Epithelial Cell (CLEC-muc). We found that
      CLEC-muc is highly proliferative and had significant clonogenic ability. These
      cells express embryonic stem cell markers OCT-4, NANOG, SSEA-4, REX1 and SOX2.
      Despite the abundant expression of epithelial cell marker MUCIN1 and
      cytokeratins, this population is also positive to the mesenchymal stem cell (MSC)
      marker CD166. CLEC-muc is unique in p63 expression that shuttles from the
      cytoplasm to the nucleus over time in culture. To understand p63 regulation and
      function in CLEC-muc, cells were treated with BMP4, a potent morphogen that plays
      a role in epidermal differentiation via p63 upregulation in ES cell and
      subsequent analyses were done. We found that BMP4 does not alter cytoplasmic
      expression of p63 that promotes cell proliferation. However, it increases nuclear
      p63 expression together with several other epithelial-associated genes such as
      GATA3, JAGGED1, NOTCH1, HES1 and IKKalpha. BMP4 has also been found to weakly
      induce deltaNp63 expression in CLEC-muc. Our results suggest that CLEC-muc is a
      novel stem cell-like population that can be further differentiated by BMP4 to
      generate specific cell-types probably destined to form non-keratinized epithelia.
FAU - Reza, Hasan Mahmud
AU  - Reza HM
AD  - Singapore Eye Research Institute, Singapore, Singapore.
FAU - Ng, Boon-Yee
AU  - Ng BY
FAU - Phan, Toan Thang
AU  - Phan TT
FAU - Tan, Donald T H
AU  - Tan DT
FAU - Beuerman, Roger W
AU  - Beuerman RW
FAU - Ang, Leonard Pek-Kiang
AU  - Ang LP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Stem Cell Rev Rep
JT  - Stem cell reviews and reports
JID - 101752767
RN  - 0 (BMP4 protein, human)
RN  - 0 (Biomarkers)
RN  - 0 (Bone Morphogenetic Protein 4)
RN  - 0 (CKAP4 protein, human)
RN  - 0 (MUC1 protein, human)
RN  - 0 (Membrane Proteins)
RN  - 0 (Mucin-1)
SB  - IM
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Bone Morphogenetic Protein 4/metabolism
MH  - Cell Proliferation
MH  - Cell Separation
MH  - Cells, Cultured
MH  - Epithelial Cells/*cytology/*physiology
MH  - Female
MH  - Flow Cytometry
MH  - Humans
MH  - Membrane Proteins/*metabolism
MH  - Mucin-1/*metabolism
MH  - Pregnancy
MH  - Stem Cells/*cytology/*physiology
MH  - Umbilical Cord/*cytology
EDAT- 2010/12/25 06:00
MHDA- 2011/11/16 06:00
CRDT- 2010/12/25 06:00
PHST- 2010/12/25 06:00 [entrez]
PHST- 2010/12/25 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - 10.1007/s12015-010-9214-6 [doi]
PST - ppublish
SO  - Stem Cell Rev Rep. 2011 Sep;7(3):624-38. doi: 10.1007/s12015-010-9214-6.


PMID- 21180837
OWN - NLM
STAT- MEDLINE
DCOM- 20110510
LR  - 20190907
IS  - 1678-4561 (Electronic)
IS  - 1413-8123 (Linking)
VI  - 16
IP  - 1
DP  - 2011 Jan
TI  - [The construction of care by the health team and the caretaker within a home-care
      program for bedridden patients in Porto Alegre (RS, Brazil)].
PG  - 301-10
LID - S1413-81232011000100032 [pii]
AB  - The main objective of this case study was to understand the construction of care 
      in the Homecare Program for Bedridden Patients (PADA) of a basic health unit
      (UBS) in Porto Alegre, RS. Data were obtained from 13 caretaker groups in the
      UBS, and participating observation recorded in field diary in the patient's
      homes. An analysis of the discourse practices was performed inspired in
      Foucault's discourse concepts speeches and in studies on ethics and self-care. In
      the groups, the caretaker occupied a space that we metaphorically called the
      Delphic Oracle, a place for acceptance, listening and support. Hearing the
      dialogues that took place between the team and the caretakers made us face the
      contradiction present in the institutional discourse, which both stimulates
      self-care, and imposes rules, duties, tasks. Care as a citizenship right opposite
      to care as submission and subjugation created tension inside the group several
      times. Foucault's notion of care comprises a synthesis of the exercise of a
      person over his- or herself, making him or her better as a human being and, at
      the same time, capacitating him or her to become a better citizen.
FAU - de Almeida Freitas, Ivani Bueno
AU  - de Almeida Freitas IB
AD  - Universidade do Vale do Rio dos Sinos, Sao Leopoldo, RS, 93022-000.
      ivanifreitas@terra.com.br
FAU - Meneghel, Stela Nazareth
AU  - Meneghel SN
FAU - Selli, Lucilda
AU  - Selli L
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - A construcao do cuidado pela equipe de saude e o cuidador em um programa de
      atencao domiciliar ao acamado em Porto Alegre (RS, Brasil).
PL  - Brazil
TA  - Cien Saude Colet
JT  - Ciencia & saude coletiva
JID - 9713483
SB  - IM
MH  - Brazil
MH  - *Home Care Services, Hospital-Based/standards
MH  - Humans
MH  - Immobilization
MH  - *Patient Care Team
EDAT- 2010/12/25 06:00
MHDA- 2011/05/11 06:00
CRDT- 2010/12/25 06:00
PHST- 2007/12/04 00:00 [received]
PHST- 2008/08/06 00:00 [accepted]
PHST- 2010/12/25 06:00 [entrez]
PHST- 2010/12/25 06:00 [pubmed]
PHST- 2011/05/11 06:00 [medline]
AID - S1413-81232011000100032 [pii]
AID - 10.1590/s1413-81232011000100032 [doi]
PST - ppublish
SO  - Cien Saude Colet. 2011 Jan;16(1):301-10. doi: 10.1590/s1413-81232011000100032.


PMID- 21180819
OWN - NLM
STAT- MEDLINE
DCOM- 20110510
LR  - 20190907
IS  - 1678-4561 (Electronic)
IS  - 1413-8123 (Linking)
VI  - 16
IP  - 1
DP  - 2011 Jan
TI  - [Food in the contemporary context: consumption, political action and
      sustainability].
PG  - 99-106
LID - S1413-81232011000100014 [pii]
AB  - The interdisciplinary field of reflections on food as politics goes through a
      process of expansion and overflow to the private sphere, and routine daily food
      consumption. This process seems to be a reflection of transformations in the
      global agrifood markets, the wide publicity and awareness of food hazards and the
      politicization of consumption. To the extent that individuals are to assume
      responsibility for the environmental and social consequences of their everyday
      choices, the specificity of political power in contemporary societies goes beyond
      the institutional level (food security and nutrition, social inequalities in
      access to food, agricultural policies and regulations advertising of food) to
      meet the private sphere. This paper shows, initially, some of the recent debates 
      about the process of politicization of consumption and then explores a
      theoretical reflection on the ethical, political and ideological habits that
      relate to food consumption, including the locations and ways of acquiring and
      food preparation, the values of environmental preservation, solidarity with local
      producers and reflexive caution against food risks. Finally, points to a research
      agenda capable of capturing the processes of politicization of food and consumer 
      practices in the field of political power.
FAU - Portilho, Fatima
AU  - Portilho F
AD  - Programa de Pos-Graduacao de Ciencias Sociais em Desenvolvimento, Agricultura e
      Sociedade, Universidade Federal Rural do Rio de Janeiro, Rio de Janeiro, RJ,
      20071-003. faportilho@uol.com.br
FAU - Castaneda, Marcelo
AU  - Castaneda M
FAU - de Castro, Ines Rugani Ribeiro
AU  - de Castro IR
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - A alimentacao no contexto contemporaneo: consumo, acao politica e
      sustentabilidade.
PL  - Brazil
TA  - Cien Saude Colet
JT  - Ciencia & saude coletiva
JID - 9713483
SB  - IM
MH  - *Food
MH  - *Politics
EDAT- 2010/12/25 06:00
MHDA- 2011/05/11 06:00
CRDT- 2010/12/25 06:00
PHST- 2010/02/10 00:00 [received]
PHST- 2010/07/12 00:00 [accepted]
PHST- 2010/12/25 06:00 [entrez]
PHST- 2010/12/25 06:00 [pubmed]
PHST- 2011/05/11 06:00 [medline]
AID - S1413-81232011000100014 [pii]
AID - 10.1590/s1413-81232011000100014 [doi]
PST - ppublish
SO  - Cien Saude Colet. 2011 Jan;16(1):99-106. doi: 10.1590/s1413-81232011000100014.


PMID- 21177753
OWN - NLM
STAT- MEDLINE
DCOM- 20110125
LR  - 20120706
IS  - 1468-2052 (Electronic)
IS  - 1359-2998 (Linking)
VI  - 96
IP  - 1
DP  - 2011 Jan
TI  - Heel blood sampling in European neonatal intensive care units: compliance with
      pain management guidelines.
PG  - F65-8
LID - 10.1136/adc.2010.186429 [doi]
AB  - OBJECTIVE: To describe the use of heel blood sampling and non-pharmacological
      analgesia in a large representative sample of neonatal intensive care units
      (NICUs) in eight European countries, and compare their self-reported practices
      with evidence-based recommendations. METHODS: Information on use of heel blood
      sampling and associated procedures (oral sweet solutions, non-nutritive sucking, 
      swaddling or positioning, topical anaesthetics and heel warming) were collected
      through a structured mail questionnaire. 284 NICUs (78% response rate)
      participated, but only 175 with >/=50 very low birth weight admissions per year
      were included in this analysis. RESULTS: Use of heel blood sampling appeared
      widespread. Most units in the Netherlands, UK, Denmark, Sweden and France
      predominantly adopted mechanical devices, while manual lance was still in use in 
      the other countries. The two Scandinavian countries and France were the most
      likely, and Belgium and Spain the least likely to employ recommended combinations
      of evidence-based pain management measures. CONCLUSIONS: Heel puncture is a
      common procedure in preterm neonates, but pain appears inadequately treated in
      many units and countries. Better compliance with published guidelines is needed
      for clinical and ethical reasons.
FAU - Losacco, Valentina
AU  - Losacco V
AD  - Unit of Epidemiology, Ospedale Pediatrico Bambino Gesu, Piazza S. Onofrio 4,
      Rome, Italy.
FAU - Cuttini, Marina
AU  - Cuttini M
FAU - Greisen, Gorm
AU  - Greisen G
FAU - Haumont, Dominique
AU  - Haumont D
FAU - Pallas-Alonso, Carmen R
AU  - Pallas-Alonso CR
FAU - Pierrat, Veronique
AU  - Pierrat V
FAU - Warren, Inga
AU  - Warren I
FAU - Smit, Bert J
AU  - Smit BJ
FAU - Westrup, Bjorn
AU  - Westrup B
FAU - Sizun, Jacques
AU  - Sizun J
CN  - ESF Network
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Arch Dis Child Fetal Neonatal Ed
JT  - Archives of disease in childhood. Fetal and neonatal edition
JID - 9501297
SB  - IM
EIN - Arch Dis Child Fetal Neonatal Ed. 2011 Feb;96(2):207
EIN - Arch Dis Child Fetal Neonatal Ed. 2012 Jun;97(6):583
MH  - Analgesia/methods/*standards
MH  - Europe
MH  - Guideline Adherence/statistics & numerical data
MH  - Heel/*blood supply
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Infant, Very Low Birth Weight
MH  - Intensive Care Units, Neonatal/*standards
MH  - Pain/etiology/*prevention & control
MH  - Phlebotomy/adverse effects/*standards
MH  - Practice Guidelines as Topic
MH  - Professional Practice/statistics & numerical data
IR  - Amiel-Tison C
FIR - Amiel-Tison, C
IR  - Browne JV
FIR - Browne, J V
IR  - Cuttini M
FIR - Cuttini, M
IR  - Greisen G
FIR - Greisen, G
IR  - Haumont D
FIR - Haumont, D
IR  - Huppi PS
FIR - Huppi, P S
IR  - Lagercrantz H
FIR - Lagercrantz, H
IR  - Stjernqvist K
FIR - Stjernqvist, K
IR  - Warren
FIR - Warren
IR  - Moquin-Pattey C
FIR - Moquin-Pattey, C
IR  - Minkowsky M
FIR - Minkowsky, M
IR  - Schaller B
FIR - Schaller, B
EDAT- 2010/12/24 06:00
MHDA- 2011/01/28 06:00
CRDT- 2010/12/24 06:00
PHST- 2010/12/24 06:00 [entrez]
PHST- 2010/12/24 06:00 [pubmed]
PHST- 2011/01/28 06:00 [medline]
AID - 96/1/F65 [pii]
AID - 10.1136/adc.2010.186429 [doi]
PST - ppublish
SO  - Arch Dis Child Fetal Neonatal Ed. 2011 Jan;96(1):F65-8. doi:
      10.1136/adc.2010.186429.


PMID- 21176817
OWN - NLM
STAT- MEDLINE
DCOM- 20110425
LR  - 20101223
IS  - 1528-395X (Electronic)
IS  - 1079-2104 (Linking)
VI  - 111
IP  - 1
DP  - 2011 Jan
TI  - Research and publication ethics: what have we learned thus far?
PG  - 10-2
LID - 10.1016/j.tripleo.2010.10.001 [doi]
FAU - Pitak-Arnnop, Poramate
AU  - Pitak-Arnnop P
FAU - Dhanuthai, Kittipong
AU  - Dhanuthai K
FAU - Hemprich, Alexander
AU  - Hemprich A
FAU - Pausch, Niels Christian
AU  - Pausch NC
LA  - eng
PT  - Comment
PT  - Letter
PL  - United States
TA  - Oral Surg Oral Med Oral Pathol Oral Radiol Endod
JT  - Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
JID - 9508562
SB  - IM
CON - Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Jun;109(6):797-8. PMID:
      20451839
MH  - *Ethics, Research
MH  - Humans
MH  - Journalism, Dental/*standards
MH  - Periodicals as Topic/ethics/standards
MH  - Publishing/*ethics
MH  - Scientific Misconduct
EDAT- 2010/12/24 06:00
MHDA- 2011/04/26 06:00
CRDT- 2010/12/24 06:00
PHST- 2010/05/28 00:00 [received]
PHST- 2010/10/01 00:00 [accepted]
PHST- 2010/12/24 06:00 [entrez]
PHST- 2010/12/24 06:00 [pubmed]
PHST- 2011/04/26 06:00 [medline]
AID - S1079-2104(10)00773-0 [pii]
AID - 10.1016/j.tripleo.2010.10.001 [doi]
PST - ppublish
SO  - Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Jan;111(1):10-2. doi:
      10.1016/j.tripleo.2010.10.001.


PMID- 21175711
OWN - NLM
STAT- MEDLINE
DCOM- 20110422
LR  - 20101223
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 25
IP  - 2
DP  - 2011 Feb
TI  - Localized past, globalized future: towards an effective bioethical framework
      using examples from population genetics and medical tourism.
PG  - 83-91
LID - 10.1111/j.1467-8519.2010.01868.x [doi]
AB  - This paper suggests that many of the pressing dilemmas of bioethics are global
      and structural in nature. Accordingly, global ethical frameworks are required
      which recognize the ethically significant factors of all global actors. To this
      end, ethical frameworks must recognize the rights and interests of both
      individuals and groups (and the interrelation of these). The paper suggests that 
      the current dominant bioethical framework is inadequate to this task as it is
      over-individualist and therefore unable to give significant weight to the ethical
      demands of groups (and by extension communal and public goods). It will explore
      this theme by considering the inadequacy of informed consent (the 'global
      standard' of bioethics) to address two pressing global bioethical issues: medical
      tourism and population genetics. Using these examples it will show why consent is
      inadequate to address all the significant features of these ethical dilemmas.
      Four key failures will be explored, namely, * That the rights and interests of
      those related (and therefore affected) are neglected; * That consent fails to
      take account of the context and commitments of individuals which may constitute
      inducement and coercion; * That consent alone does not have the ethical weight to
      negate exploitation or make an unjust action just ('the fallacy of sufficiency');
      * That consent is a single one-off act which is inappropriate for the types of
      decision being made. It will conclude by suggesting that more appropriate models 
      are emerging, particularly in population genetics, which can supplement consent.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Widdows, Heather
AU  - Widdows H
AD  - Department of Philosophy at the University of Birmingham, Edgbaston,Birmingham.
      h.widdows@bham.ac.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Bioethics/*trends
MH  - Biological Specimen Banks/ethics
MH  - Genetics, Population/*ethics
MH  - Humans
MH  - Informed Consent/*ethics
MH  - *Internationality
MH  - Medical Tourism/*ethics
MH  - Models, Theoretical
MH  - Tissue and Organ Procurement/ethics
MH  - Vulnerable Populations
EDAT- 2010/12/24 06:00
MHDA- 2011/04/26 06:00
CRDT- 2010/12/24 06:00
PHST- 2010/12/24 06:00 [entrez]
PHST- 2010/12/24 06:00 [pubmed]
PHST- 2011/04/26 06:00 [medline]
AID - 10.1111/j.1467-8519.2010.01868.x [doi]
PST - ppublish
SO  - Bioethics. 2011 Feb;25(2):83-91. doi: 10.1111/j.1467-8519.2010.01868.x.


PMID- 21175710
OWN - NLM
STAT- MEDLINE
DCOM- 20110422
LR  - 20101223
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 25
IP  - 2
DP  - 2011 Feb
TI  - Looking backwards, looking forward: hopes for bioethics' next twenty-five years.
PG  - 75-82
LID - 10.1111/j.1467-8519.2010.01866.x [doi]
AB  - I reflect on the past, present, and future of the field of bioethics. In so
      doing, I offer a very situated overview of where bioethics has been, where it now
      is, where it seems to be going, where I think we could do better, and where I
      dearly hope the field will be heading. I also propose three ways of re-orienting 
      our theoretic tools to guide us in a new direction: (1) adopt an ethics of
      responsibility; (2) explore the responsibilities of various kinds of actors and
      relationships among them; (3) expand the types of participants engaged in
      bioethics.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Sherwin, Susan
AU  - Sherwin S
AD  - Department of Philosophy, Dalhousie University, Halifax, Nova Scotia B3H 4P9,
      Canada. ssherwin@dal.ca
LA  - eng
PT  - Journal Article
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Bioethics/*trends
MH  - Humans
MH  - Models, Theoretical
MH  - *Social Justice
EDAT- 2010/12/24 06:00
MHDA- 2011/04/26 06:00
CRDT- 2010/12/24 06:00
PHST- 2010/12/24 06:00 [entrez]
PHST- 2010/12/24 06:00 [pubmed]
PHST- 2011/04/26 06:00 [medline]
AID - 10.1111/j.1467-8519.2010.01866.x [doi]
PST - ppublish
SO  - Bioethics. 2011 Feb;25(2):75-82. doi: 10.1111/j.1467-8519.2010.01866.x.


PMID- 21175709
OWN - NLM
STAT- MEDLINE
DCOM- 20110422
LR  - 20101223
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 25
IP  - 2
DP  - 2011 Feb
TI  - Was bioethics founded on historical and conceptual mistakes about medical
      paternalism?
PG  - 66-74
LID - 10.1111/j.1467-8519.2010.01867.x [doi]
AB  - Bioethics has a founding story in which medical paternalism, the interference
      with the autonomy of patients for their own clinical benefit, was an accepted
      ethical norm in the history of Western medical ethics and was widespread in
      clinical practice until bioethics changed the ethical norms and practice of
      medicine. In this paper I show that the founding story of bioethics misreads
      major texts in the history of Western medical ethics. I also show that a major
      source for empirical claims about the widespread practice of medical paternalism 
      has been misread. I then show that that bioethics based on its founding story
      deprofessionalizes medical ethics. The result leaves the sick exposed to the
      predatory power of medical practitioners and healthcare organizations with only
      their autonomy-based rights to non-interference, expressed in contracts, to
      protect them. The sick are stripped of the protection afforded by a professional,
      fiduciary relationship of physicians to their patients. Bioethics based on its
      founding story reverts to the older model of a contractual relationship between
      the sick and medical practitioners not worthy of intellectual or moral trust
      (because such trust cannot be generated by what I call 'deprofessionalizing
      bioethics'). On closer examination, bioethics based on its founding story,
      ironically, eliminates paternalism as a moral category in bioethics, thus causing
      bioethics to collapse on itself because it denies one of the necessary conditions
      for medical paternalism. Bioethics based on its founding story should be
      abandoned.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - McCullough, Laurence B
AU  - McCullough LB
AD  - Center for Medical Ethics and Health Policy, Baylor College of Medicine, One
      Baylor Plaza MS 420, Houston, TX 77030-3411, USA. mccullou@bcm.edu
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Bioethics/education/*history
MH  - Ethical Theory
MH  - History, 18th Century
MH  - History, 19th Century
MH  - History, 20th Century
MH  - History, Ancient
MH  - Humans
MH  - Paternalism/*ethics
MH  - Patient Rights/ethics/history
MH  - Physician's Role
MH  - Physician-Patient Relations/*ethics
MH  - Social Responsibility
MH  - Western World
EDAT- 2010/12/24 06:00
MHDA- 2011/04/26 06:00
CRDT- 2010/12/24 06:00
PHST- 2010/12/24 06:00 [entrez]
PHST- 2010/12/24 06:00 [pubmed]
PHST- 2011/04/26 06:00 [medline]
AID - 10.1111/j.1467-8519.2010.01867.x [doi]
PST - ppublish
SO  - Bioethics. 2011 Feb;25(2):66-74. doi: 10.1111/j.1467-8519.2010.01867.x.


PMID- 21175707
OWN - NLM
STAT- MEDLINE
DCOM- 20110422
LR  - 20101223
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 25
IP  - 2
DP  - 2011 Feb
TI  - Publishing bioethics and bioethics--reflections on academic publishing by a
      journal editor.
PG  - 57-61
LID - 10.1111/j.1467-8519.2010.01878.x [doi]
AB  - This article by one of the Editors of Bioethics, published in the 25th
      anniversary issue of the journal, describes some of the revolutionary changes
      academic publishing has undergone during the last decades. Many humanities
      journals went from typically small print-runs, counting by the hundreds, to
      on-line availability in thousands of university libraries worldwide. Article
      up-take by our subscribers can be measured efficiently. The implications of this 
      and other changes to academic publishing are discussed. Important ethical
      challenges need to be addressed in areas such as the enforcement of
      plagiarism-related policies, the so-called 'impact factor' and its impact on
      academic integrity, and the question of whether on-line only publishing can
      currently guarantee the integrity of academic publishing histories.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Schuklenk, Udo
AU  - Schuklenk U
AD  - Department of Philosophy, Queen's University, Kingston, Ontario, Canada.
      udo.schuklenk@gmail.com
LA  - eng
PT  - Journal Article
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - *Bioethics
MH  - Humans
MH  - Information Dissemination
MH  - Journal Impact Factor
MH  - Online Systems
MH  - Periodicals as Topic/*ethics/*trends
MH  - Plagiarism
MH  - Publishing/*ethics/*trends
EDAT- 2010/12/24 06:00
MHDA- 2011/04/26 06:00
CRDT- 2010/12/24 06:00
PHST- 2010/12/24 06:00 [entrez]
PHST- 2010/12/24 06:00 [pubmed]
PHST- 2011/04/26 06:00 [medline]
AID - 10.1111/j.1467-8519.2010.01878.x [doi]
PST - ppublish
SO  - Bioethics. 2011 Feb;25(2):57-61. doi: 10.1111/j.1467-8519.2010.01878.x.


PMID- 21173798
OWN - NLM
STAT- MEDLINE
DCOM- 20110228
LR  - 20211020
IS  - 1476-4679 (Electronic)
IS  - 1465-7392 (Linking)
VI  - 13
IP  - 1
DP  - 2011 Jan
TI  - Combating scientific misconduct.
PG  - 1
LID - 10.1038/ncb0111-1 [doi]
AB  - The pressures of an increasingly competitive research environment can lead to
      scientific misconduct. Journals, academic institutions and individual scientists 
      should commit to promoting best practice in research and education in research
      ethics.
LA  - eng
PT  - Editorial
PL  - England
TA  - Nat Cell Biol
JT  - Nature cell biology
JID - 100890575
SB  - IM
MH  - *Ethics, Research
MH  - Humans
MH  - Research/*standards
MH  - Research Personnel/ethics/standards
MH  - Scientific Misconduct/*ethics
EDAT- 2010/12/22 06:00
MHDA- 2011/03/01 06:00
CRDT- 2010/12/22 06:00
PHST- 2010/12/22 06:00 [entrez]
PHST- 2010/12/22 06:00 [pubmed]
PHST- 2011/03/01 06:00 [medline]
AID - ncb0111-1 [pii]
AID - 10.1038/ncb0111-1 [doi]
PST - ppublish
SO  - Nat Cell Biol. 2011 Jan;13(1):1. doi: 10.1038/ncb0111-1.


PMID- 21173772
OWN - NLM
STAT- MEDLINE
DCOM- 20110505
LR  - 20101221
IS  - 1548-4475 (Electronic)
IS  - 0093-7355 (Linking)
VI  - 40
IP  - 1
DP  - 2011 Jan
TI  - The role of organizational culture in compliance with the principles of the 3Rs.
PG  - 22-6
LID - 10.1038/laban0111-22 [doi]
AB  - In order for their research to be legitimate, scientists carrying out research
      using animals must comply with rules and regulations. The 3Rs (replacement,
      reduction and refinement) are one set of guidelines that help to promote the
      ethical use of animals for research. An important question is whether
      implementing the principles of the 3Rs in legal regulations, such as a Directive 
      of the European Parliament and of the Council on the protection of animals used
      for scientific purposes, will increase compliance with the principles of the 3Rs 
      in research organizations. Previous work suggests that organizational culture is 
      just as important for directing behavior as are formalized rules and regulations.
      This article introduces the concepts of compliance and organizational culture and
      discusses their consequences on the implementation of the principles of the 3Rs.
FAU - Bronstad, Aurora
AU  - Bronstad A
AD  - Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway.
      aurora.bronstad@ffhs.uib.no
FAU - Berg, Anne-Grethe Tronsdal
AU  - Berg AG
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Lab Anim (NY)
JT  - Lab animal
JID - 0417737
SB  - IM
MH  - *Animal Rights
MH  - Animal Testing Alternatives/*ethics/methods
MH  - Animal Welfare/*legislation & jurisprudence
MH  - Animals
MH  - Animals, Laboratory
MH  - Biomedical Research/*ethics
MH  - Guideline Adherence
MH  - Guidelines as Topic
MH  - *Organizational Culture
EDAT- 2010/12/22 06:00
MHDA- 2011/05/06 06:00
CRDT- 2010/12/22 06:00
PHST- 2010/05/03 00:00 [received]
PHST- 2010/10/21 00:00 [accepted]
PHST- 2010/12/22 06:00 [entrez]
PHST- 2010/12/22 06:00 [pubmed]
PHST- 2011/05/06 06:00 [medline]
AID - laban0111-22 [pii]
AID - 10.1038/laban0111-22 [doi]
PST - ppublish
SO  - Lab Anim (NY). 2011 Jan;40(1):22-6. doi: 10.1038/laban0111-22.


PMID- 21170753
OWN - NLM
STAT- MEDLINE
DCOM- 20110819
LR  - 20211020
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 23
IP  - 1
DP  - 2011 Mar
TI  - Bioethics training in Uganda: report on research and clinical ethics workshops.
PG  - 43-56
LID - 10.1007/s10730-010-9144-3 [doi]
AB  - This essay describes and critically evaluates a co-operative educational program 
      to train Ugandan health care workers in bioethics. It describes one "bottom-up"
      effort, a week-long intensive workshop in bioethics provided by the authors to
      health care professionals in a developing country-Uganda. We will describe the
      background and circumstances that led to the organization of the workshop, and
      review its planning, design, curriculum, and outcome. We will focus especially on
      measures taken to make the workshop relevant for the audience of Ugandan
      professionals, and describe lessons learned after two presentations of the
      workshop. Finally, we will discuss the strengths and weaknesses of such a format,
      and its potential value in raising bioethical expertise in developing countries.
FAU - Griggins, Cynthia
AU  - Griggins C
AD  - Clinical Ethics Service, University Hospitals Case Medical Center, Cleveland, OH 
      441006, USA. cynthia.griggins@case.edu
FAU - Simon, Christian
AU  - Simon C
FAU - Nakwagala, Frederick Nelson
AU  - Nakwagala FN
FAU - Pentz, Rebecca D
AU  - Pentz RD
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - Bioethics/*education
MH  - *Education
MH  - Ethics, Clinical/*education
MH  - Female
MH  - Health Services Accessibility
MH  - Humans
MH  - Male
MH  - Research/*education
MH  - Uganda
EDAT- 2010/12/21 06:00
MHDA- 2011/08/20 06:00
CRDT- 2010/12/21 06:00
PHST- 2010/12/21 06:00 [entrez]
PHST- 2010/12/21 06:00 [pubmed]
PHST- 2011/08/20 06:00 [medline]
AID - 10.1007/s10730-010-9144-3 [doi]
PST - ppublish
SO  - HEC Forum. 2011 Mar;23(1):43-56. doi: 10.1007/s10730-010-9144-3.


PMID- 21170752
OWN - NLM
STAT- MEDLINE
DCOM- 20110819
LR  - 20211020
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 23
IP  - 1
DP  - 2011 Mar
TI  - The oversight and practice of oocyte donation in the United States, United
      Kingdom and Canada.
PG  - 15-30
LID - 10.1007/s10730-010-9145-2 [doi]
AB  - In vitro fertilization using donated oocytes is an important medical technique
      that provides the only option for some infertile patients to have children. The
      technique remains ethically contentious, however, and, as a result of this
      controversy, different oversight approaches have been developed in countries
      around the world. This paper examines the oversight and practice of oocyte
      donation in Canada, the United Kingdom and the United States to examine how
      policy choices have influenced the development and use of this medical
      technology. Examining per capita utilization of oocyte donation in these three
      countries provides evidence that supply-side policies-specifically policies
      affecting the compensation of potential oocyte donors-have substantially
      influenced the use of this technology. These results should provide useful
      insight for policymakers developing or revising oocyte donation policies.
FAU - Levine, Aaron D
AU  - Levine AD
AD  - School of Public Policy, Georgia Institute of Technology, Atlanta, 30332-0345,
      USA. aaron.levine@pubpolicy.gatech.edu
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - Canada
MH  - *Government Regulation
MH  - Health Policy
MH  - Humans
MH  - Oocyte Donation/*ethics/legislation & jurisprudence
MH  - Reproductive Techniques, Assisted/ethics
MH  - United Kingdom
MH  - United States
EDAT- 2010/12/21 06:00
MHDA- 2011/08/20 06:00
CRDT- 2010/12/21 06:00
PHST- 2010/12/21 06:00 [entrez]
PHST- 2010/12/21 06:00 [pubmed]
PHST- 2011/08/20 06:00 [medline]
AID - 10.1007/s10730-010-9145-2 [doi]
PST - ppublish
SO  - HEC Forum. 2011 Mar;23(1):15-30. doi: 10.1007/s10730-010-9145-2.


PMID- 21161549
OWN - NLM
STAT- MEDLINE
DCOM- 20110804
LR  - 20211020
IS  - 1432-2129 (Electronic)
IS  - 0932-433X (Linking)
VI  - 25
IP  - 1
DP  - 2011 Feb
TI  - [Save life--allow death. Collation of emergency missions for terminally ill
      patients].
PG  - 69-76
LID - 10.1007/s00482-010-1000-5 [doi]
AB  - BACKGROUND: Emergency missions can also be necessary for patients in the terminal
      phase of a progressive incurable disease. The emergency physician, accustomed to 
      acting under strict procedures and whose training focuses on the restoration and 
      stabilization of acutely threatened vital functions, can face severe difficulties
      when treating incurably ill patients in the terminal phase. This study
      investigates the number of such cases, patient symptoms and the events occurring 
      during life-threatening emergencies of terminally ill patients. METHOD: All cases
      of emergency events involving terminally ill patients were analyzed
      prospectively. In addition to the standardized protocol (following DIVI/Mind 2)
      an enquiry sheet was used, which contained an 8-item checklist specifically for
      terminally ill patients, to be filled out by the responding physician. RESULTS:
      The total number of patients in the terminal phase identified by the emergency
      physician was 55 (0.72% of total cases) and of these patients 30 (55%) were tumor
      patients. The most frequent complaint observed was dyspnea (30 patients, 55%),
      followed by relatives of the patients experiencing the stress of caring for a
      terminally ill person (19 patients, 35%). The leading symptom of 6 patients (11%)
      was pain. Only 17 cases (30.9%) required transport of the patient to hospital for
      further treatment. CONCLUSION: Every emergency physician can be confronted with
      an emergency involving a patient with a progressive incurable disease. The
      condition of each patient must be assessed for each medical decision. Not only
      medical, but also psychosocial, ethical and legal aspects have to be considered.
FAU - Laufenberg-Feldmann, R
AU  - Laufenberg-Feldmann R
AD  - Klinik fur Anasthesiologie, Universitatsmedizin der Johannes
      Gutenberg-Universitat Mainz, Langenbeckstr. 1, 55131 Mainz, Deutschland.
      rita.laufenberg@unimedizin-mainz.de
FAU - Kappis, B
AU  - Kappis B
FAU - Weber, M
AU  - Weber M
FAU - Werner, C
AU  - Werner C
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Leben retten--sterben zulassen. Erfassung notarztlicher Einsatze bei Patienten in
      der Terminalphase.
PL  - Germany
TA  - Schmerz
JT  - Schmerz (Berlin, Germany)
JID - 8906258
SB  - IM
MH  - Adult
MH  - Advance Directives
MH  - Aged
MH  - Aged, 80 and over
MH  - Caregivers/psychology
MH  - Checklist
MH  - Cost of Illness
MH  - Decision Making
MH  - Emergency Medical Services/*ethics/*methods
MH  - Ethics, Medical
MH  - Euthanasia, Passive/*ethics
MH  - Female
MH  - Germany
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pain Management
MH  - Palliative Care/*ethics/*methods
MH  - Professional-Family Relations
MH  - Prospective Studies
MH  - Resuscitation/*ethics/mortality
MH  - Survival Analysis
MH  - Terminal Care/*ethics/*methods
MH  - Transportation of Patients/ethics
EDAT- 2010/12/17 06:00
MHDA- 2011/08/05 06:00
CRDT- 2010/12/17 06:00
PHST- 2010/12/17 06:00 [entrez]
PHST- 2010/12/17 06:00 [pubmed]
PHST- 2011/08/05 06:00 [medline]
AID - 10.1007/s00482-010-1000-5 [doi]
PST - ppublish
SO  - Schmerz. 2011 Feb;25(1):69-76. doi: 10.1007/s00482-010-1000-5.


PMID- 21161442
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20211020
IS  - 2629-3277 (Electronic)
IS  - 2629-3277 (Linking)
VI  - 7
IP  - 3
DP  - 2011 Sep
TI  - In delicate balance: stem cells and spinal cord injury advocacy.
PG  - 657-63
LID - 10.1007/s12015-010-9211-9 [doi]
AB  - Spinal cord injury (SCI) is a major focus for stem cell therapy (SCT). However,
      the science of SCT has not been well matched with an understanding of
      perspectives of persons with SCI. The online advocacy community is a key source
      of health information for primary stakeholders and their caregivers. In this
      study, we sought to characterize the content of SCI advocacy websites with
      respect to their discussion of SCT and stem cell tourism. We performed a
      comprehensive analysis of SCI advocacy websites identified through a web search
      and verified by expert opinion. Two independent researchers coded the information
      for major themes (e.g., scientific & clinical facts, research & funding, policy, 
      ethics) and valence (positive, negative, balanced, neutral). Of the 40 SCI
      advocacy websites that met inclusion criteria, 50% (N=20) contained information
      about SCT. Less than 18% (N=7) contained information on stem cell tourism. There 
      were more than ten times as many statements about SCT with a positive valence
      (N=67) as with a negative valence (N=6). Ethics-related SCT information comprised
      20% (N=37) of the total content; the largest proportion of ethics-related content
      was devoted to stem cell tourism (80%, N=30 statements). Of those, the majority
      focused on the risks of stem cell tourism (N=16). Given the still-developing
      science behind SCT, the presence of cautionary information about stem cell
      tourism at advocacy sites is ethically appropriate. The absence of stem cell
      tourism information at the majority of advocacy sites represents a lost
      educational opportunity.
FAU - Parke, Sara
AU  - Parke S
AD  - National Core for Neuroethics, University of British Columbia, Vancouver, BC V6T 
      2B5, Canada. sparke87@gmail.com
FAU - Illes, Judy
AU  - Illes J
LA  - eng
GR  - 85117/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Stem Cell Rev Rep
JT  - Stem cell reviews and reports
JID - 101752767
SB  - IM
MH  - Clinical Coding
MH  - Clinical Trials as Topic
MH  - Humans
MH  - *Internet
MH  - *Medical Tourism
MH  - Policy
MH  - Spinal Cord Injuries/*therapy
MH  - *Stem Cell Research/economics/ethics/legislation & jurisprudence
MH  - *Stem Cell Transplantation/ethics/legislation & jurisprudence/standards
MH  - *Stem Cells
EDAT- 2010/12/17 06:00
MHDA- 2011/11/16 06:00
CRDT- 2010/12/17 06:00
PHST- 2010/12/17 06:00 [entrez]
PHST- 2010/12/17 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - 10.1007/s12015-010-9211-9 [doi]
PST - ppublish
SO  - Stem Cell Rev Rep. 2011 Sep;7(3):657-63. doi: 10.1007/s12015-010-9211-9.


PMID- 21158873
OWN - NLM
STAT- MEDLINE
DCOM- 20110422
LR  - 20101216
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 25
IP  - 1
DP  - 2011 Jan
TI  - Human subjects research with prisoners: putting the ethical question in context.
PG  - 55-6
LID - 10.1111/j.1467-8519.2010.01859.x [doi]
FAU - Obasogie, Osagie K
AU  - Obasogie OK
FAU - Reiter, Keramet A
AU  - Reiter KA
LA  - eng
PT  - Comment
PT  - Letter
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
CON - Bioethics. 2010 Jan;24(1):1-13. PMID: 20017742
CON - Bioethics. 2010 Jan;24(1):14-22. PMID: 20017743
CON - Bioethics. 2010 Jan;24(1):23-6. PMID: 20017744
MH  - *Coercion
MH  - Controlled Clinical Trials as Topic/*ethics
MH  - Educational Status
MH  - Ethics, Research
MH  - Government Regulation
MH  - Human Experimentation/ethics/legislation & jurisprudence
MH  - Humans
MH  - Motivation
MH  - *Prisoners
MH  - Public Policy
MH  - *Quality of Health Care/ethics/standards
MH  - Research Subjects
MH  - Therapeutic Human Experimentation/*ethics/legislation & jurisprudence
MH  - United States
MH  - Vulnerable Populations
EDAT- 2010/12/17 06:00
MHDA- 2011/04/26 06:00
CRDT- 2010/12/17 06:00
PHST- 2010/12/17 06:00 [entrez]
PHST- 2010/12/17 06:00 [pubmed]
PHST- 2011/04/26 06:00 [medline]
AID - 10.1111/j.1467-8519.2010.01859.x [doi]
PST - ppublish
SO  - Bioethics. 2011 Jan;25(1):55-6. doi: 10.1111/j.1467-8519.2010.01859.x.


PMID- 21158872
OWN - NLM
STAT- MEDLINE
DCOM- 20110422
LR  - 20101216
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 25
IP  - 1
DP  - 2011 Jan
TI  - Bio- and security ethics: only connect.
PG  - ii
LID - 10.1111/j.1467-8519.2010.01877.x [doi]
FAU - Chadwick, Ruth
AU  - Chadwick R
LA  - eng
PT  - Editorial
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Biotechnology/*ethics
MH  - Humans
MH  - Security Measures/*ethics
EDAT- 2010/12/17 06:00
MHDA- 2011/04/26 06:00
CRDT- 2010/12/17 06:00
PHST- 2010/12/17 06:00 [entrez]
PHST- 2010/12/17 06:00 [pubmed]
PHST- 2011/04/26 06:00 [medline]
AID - 10.1111/j.1467-8519.2010.01877.x [doi]
PST - ppublish
SO  - Bioethics. 2011 Jan;25(1):ii. doi: 10.1111/j.1467-8519.2010.01877.x.


PMID- 21157312
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20110309
IS  - 1531-7072 (Electronic)
IS  - 1070-5295 (Linking)
VI  - 17
IP  - 2
DP  - 2011 Apr
TI  - The European clinical trials directive and its impact on critical care and
      emergency research.
PG  - 141-5
LID - 10.1097/MCC.0b013e328342a6b0 [doi]
AB  - PURPOSE OF REVIEW: The European Clinical Trials Directive was issued in 2001 and 
      aimed to simplify and harmonize the regulatory framework of clinical trials
      throughout Europe, thus stimulating European research. However, significant
      complexity and inconsistency remains due to disparate interpretation by European 
      Union member states, creating substantial financial and administrative challenges
      for investigators. RECENT FINDINGS: Critical care research has been particularly 
      impacted by the Directive due to variable and often restrictive consenting
      procedures for incapacitated patients. Furthermore, the absence of a waiver of
      consent threatened to put an end to emergency research in Europe. Approval
      procedures by ethics committees are equally inconsistent, particularly those
      relating to provision of a single opinion for multicentre trials. This complexity
      as well as a general increase in administrative and financial burden following
      the Directive has been widely shown to cause a reduction in clinical trial
      activity in Europe. SUMMARY: Various changes to the Directive have been called
      for by clinical researchers from diverse disciplines, including a risk-based
      approach to ethical approval, insurance, and monitoring; clarification of terms; 
      and a general simplification of administrative procedures to reduce complexity
      and cost. This widespread advocacy has led to a planned revision of the Directive
      in 2011.
FAU - Robinson, Katy
AU  - Robinson K
AD  - College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, 
      Scotland, UK.
FAU - Andrews, Peter J D
AU  - Andrews PJ
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Crit Care
JT  - Current opinion in critical care
JID - 9504454
SB  - IM
MH  - Clinical Trials as Topic/*legislation & jurisprudence
MH  - Critical Care/*legislation & jurisprudence
MH  - Europe
MH  - Government Regulation
MH  - Health Services Research/*legislation & jurisprudence
MH  - Humans
EDAT- 2010/12/16 06:00
MHDA- 2011/07/27 06:00
CRDT- 2010/12/16 06:00
PHST- 2010/12/16 06:00 [entrez]
PHST- 2010/12/16 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
AID - 10.1097/MCC.0b013e328342a6b0 [doi]
PST - ppublish
SO  - Curr Opin Crit Care. 2011 Apr;17(2):141-5. doi: 10.1097/MCC.0b013e328342a6b0.


PMID- 21157023
OWN - NLM
STAT- MEDLINE
DCOM- 20110505
LR  - 20110819
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Linking)
VI  - 23
IP  - 1
DP  - 2011
TI  - Gerontechnology for demented patients: smart homes for smart aging.
PG  - 143-6
LID - 10.3233/JAD-2010-101599 [doi]
AB  - In an aging world, maintaining good health and independence for as long as
      possible is essential. Instead of hospitalization or institutionalization, the
      elderly with chronic conditions, especially those with cognitive impairment, can 
      be assisted in their own environment with numerous 'smart' devices that support
      them in their activity of daily living. A "smart home" is a residence equipped
      with technology that facilitates monitoring of residents to improve quality of
      life and promote physical independence, as well as to reduce caregiver burden.
      Several projects worldwide have been conducted, but some ethical and legal issues
      are still unresolved and, at present, there is no evidence of the effects of
      smart homes on health outcomes. Randomized controlled trials are needed to
      understand the plus and minuses of these projects, but this will only be possible
      with a widespread proliferation and penetration of smart homes in the social
      network.
FAU - Frisardi, Vincenza
AU  - Frisardi V
AD  - Department of Geriatrics, Center for Aging Brain, Memory Unit, University of
      Bari, Bari, Italy. vfrisardi@yahoo.com
FAU - Imbimbo, Bruno P
AU  - Imbimbo BP
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
SB  - IM
MH  - Aged
MH  - Communication
MH  - Dementia/*nursing
MH  - Female
MH  - Geriatrics/*methods
MH  - *Home Care Services
MH  - Housing for the Elderly
MH  - Humans
MH  - Male
MH  - Social Environment
MH  - Telemedicine/*methods
MH  - Telemetry/*methods
EDAT- 2010/12/16 06:00
MHDA- 2011/05/06 06:00
CRDT- 2010/12/16 06:00
PHST- 2010/12/16 06:00 [entrez]
PHST- 2010/12/16 06:00 [pubmed]
PHST- 2011/05/06 06:00 [medline]
AID - W881X62287U02867 [pii]
AID - 10.3233/JAD-2010-101599 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2011;23(1):143-6. doi: 10.3233/JAD-2010-101599.


PMID- 21153449
OWN - NLM
STAT- MEDLINE
DCOM- 20110630
LR  - 20211020
IS  - 1708-0428 (Electronic)
IS  - 0960-8923 (Linking)
VI  - 21
IP  - 3
DP  - 2011 Mar
TI  - Gastric bypass in the treatment of type 2 diabetes in patients with a BMI of 30
      to 35 kg/m2.
PG  - 283-7
LID - 10.1007/s11695-010-0318-5 [doi]
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) and class I obesity, which are
      pandemics of considerable socioeconomic importance, require new treatment
      modalities due to inadequate control through normal clinical conduct. The aim of 
      the present study was to assess the efficacy and safety of Roux-en-Y gastric
      bypass (RYGB) in the control of T2DM in patients with a body mass index (BMI) of 
      30 to 35 kg/m(2). METHODS: An observational, retrospective study was carried out 
      at the Universidade Federal de Pernambuco-Brazil. Between 2002 and 2008, 27
      patients were submitted to RYGB for the treatment of uncontrolled T2DM, with a
      mean follow-up period of 20 months. An assessment was performed of the complete
      resolution of T2DM [HbA(1c) < 6%/fasting plasma glucose (FPG) < 100 mg/dL/no
      diabetes medication] and glycemic control. The ethics committee of the university
      approved the study. RESULTS: RYGB led to the following results: (1) 23% weight
      reduction (p < 0.001), BMI stabilized at 25.6 kg/m(2) in a mean of 12 months; (2)
      46% reduction in glycemia and 27% reduction in HbA(1c) (p < 0.001); (3) 100%
      improvement in glycemia and 48% resolution of T2DM; (4) glycemic control was 74% 
      without medication and 93% with medication and five patients required medication 
      in addition to RYGB; (5) mean current FPG is 93 mg/dL and HbA(1c) is 6%; and (6) 
      there were no severe complications or deaths. CONCLUSIONS: RYGB is a safe and
      effective option in the treatment of uncompensated T2DM associated to class I
      obesity.
FAU - de Sa, Vladimir Curvelo Tavares
AU  - de Sa VC
AD  - Universidade Federal de Pernambuco, Recife, Brazil. vctdesa@yahoo.com.br
FAU - Ferraz, Alvaro A
AU  - Ferraz AA
FAU - Campos, Josemberg M
AU  - Campos JM
FAU - Ramos, Almino C
AU  - Ramos AC
FAU - Araujo, Jose Guido C Jr
AU  - Araujo JG Jr
FAU - Ferraz, Edmundo M
AU  - Ferraz EM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Obes Surg
JT  - Obesity surgery
JID - 9106714
SB  - IM
MH  - Adult
MH  - Body Mass Index
MH  - Comorbidity
MH  - Diabetes Mellitus, Type 2/*epidemiology/prevention & control/*surgery
MH  - Female
MH  - *Gastric Bypass
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity, Morbid/*epidemiology/surgery
MH  - Retrospective Studies
MH  - Treatment Outcome
MH  - Weight Loss
EDAT- 2010/12/15 06:00
MHDA- 2011/07/01 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/07/01 06:00 [medline]
AID - 10.1007/s11695-010-0318-5 [doi]
PST - ppublish
SO  - Obes Surg. 2011 Mar;21(3):283-7. doi: 10.1007/s11695-010-0318-5.


PMID- 21152990
OWN - NLM
STAT- MEDLINE
DCOM- 20111201
LR  - 20211020
IS  - 1573-3394 (Electronic)
IS  - 1065-3058 (Linking)
VI  - 19
IP  - 1
DP  - 2011 Mar
TI  - A narrative ethics of care.
PG  - 28-40
LID - 10.1007/s10728-010-0162-8 [doi]
AB  - If ethics of care deals with the nature of relationships, attentiveness, and
      understanding particular others, narrativity ought to play a central part.
      Sometimes, caring simply amounts to working with narratives. In the article I
      claim that narrativity can even be said to be native to an ethics of care.
      Through an example, I demonstrate how a narrative ethics of care can discern and 
      grasp some moral problems better than the standard theoretical outlooks.
FAU - Paulsen, Jens Erik
AU  - Paulsen JE
AD  - Section for Medical Ethics, Department of General Practice and Community
      Medicine, University of Oslo, PO Box 1130, Blindern, 0318 Oslo, Norway.
      jenserikpaulsen@hotmail.com
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Health Care Anal
JT  - Health care analysis : HCA : journal of health philosophy and policy
JID - 9432537
MH  - Blood Transfusion/ethics
MH  - Decision Making
MH  - Delivery of Health Care/*ethics
MH  - Empathy/*ethics
MH  - Humans
MH  - Jehovah's Witnesses
MH  - *Narration
PMC - PMC3037473
EDAT- 2010/12/15 06:00
MHDA- 2011/12/13 00:00
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/s10728-010-0162-8 [doi]
PST - ppublish
SO  - Health Care Anal. 2011 Mar;19(1):28-40. doi: 10.1007/s10728-010-0162-8.


PMID- 21150703
OWN - NLM
STAT- MEDLINE
DCOM- 20110511
LR  - 20211020
IS  - 1534-6080 (Electronic)
IS  - 0041-1337 (Linking)
VI  - 91
IP  - 6
DP  - 2011 Mar 27
TI  - Media appeals by pediatric patients for living donors and the impact on a
      transplant center.
PG  - 593-6
LID - 10.1097/TP.0b013e3182063066 [doi]
AB  - Little is published regarding the effect of advertising for kidney donors on
      transplant centers. At our center, families of nine children used media appeals. 
      Per candidate, there were 8 to 260 potential donor calls, 92 (11.6%) were
      medically ineligible, 326 (41.1%) voluntarily did not proceed or an alternate
      donor had been approved, 38 (4.8%) were ABO incompatible, and 327 (41.1%) had
      positive crossmatch or unsuitable human leukocyte antigens. Media appeals
      resulted in four living donor transplants and five nondirected donors to other
      candidates, and we made directed changes in our center. The ethical debate of
      advertising for organ donors continues.
FAU - Verghese, Priya S
AU  - Verghese PS
AD  - Department of Transplantation, University of Minnesota Medical Center,
      Minneapolis, MN 55455, USA. pverghes@umn.edu
FAU - Garvey, Catherine A
AU  - Garvey CA
FAU - Mauer, Michael S
AU  - Mauer MS
FAU - Matas, Arthur J
AU  - Matas AJ
LA  - eng
GR  - P01 DK013083/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Histocompatibility Testing
MH  - Humans
MH  - Infant
MH  - *Kidney Transplantation
MH  - *Living Donors
MH  - Male
MH  - *Mass Media
MH  - Middle Aged
MH  - Referral and Consultation
MH  - *Tissue and Organ Procurement
PMC - PMC3565833
MID - NIHMS435832
EDAT- 2010/12/15 06:00
MHDA- 2011/05/12 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/05/12 06:00 [medline]
AID - 10.1097/TP.0b013e3182063066 [doi]
PST - ppublish
SO  - Transplantation. 2011 Mar 27;91(6):593-6. doi: 10.1097/TP.0b013e3182063066.


PMID- 21149367
OWN - NLM
STAT- MEDLINE
DCOM- 20110329
LR  - 20211020
IS  - 1471-2970 (Electronic)
IS  - 0962-8436 (Linking)
VI  - 366
IP  - 1562
DP  - 2011 Jan 27
TI  - Computational modelling of lung injury: is there potential for benefit?
PG  - 300-5
LID - 10.1098/rstb.2010.0250 [doi]
AB  - State-of-the-art medical care of the victims of current conflicts is generating
      large quantities of quality clinical data as a by-product. Observational research
      based on these data is beginning to have a profound influence on the clinical
      management of both military and civilian trauma patients. Computational modelling
      based on these datasets may offer the ability to investigate clinical treatment
      strategies that are practically, ethically or scientifically impossible to
      investigate on the front line. This article reviews the potential of this novel
      technology to aid development of treatment for blast lung and other unresolved
      medical scenarios.
FAU - Harvey, Daniel J R
AU  - Harvey DJ
AD  - Division of Anaesthesia and Intensive Care, University of Nottingham and
      Nottingham University Hospitals NHS Trust, Nottingham, UK.
FAU - Hardman, Jonathan G
AU  - Hardman JG
LA  - eng
PT  - Journal Article
PL  - England
TA  - Philos Trans R Soc Lond B Biol Sci
JT  - Philosophical transactions of the Royal Society of London. Series B, Biological
      sciences
JID - 7503623
SB  - IM
MH  - Blast Injuries/*physiopathology
MH  - Computational Biology/*methods
MH  - Computer Simulation
MH  - Humans
MH  - *Models, Biological
MH  - Respiratory Distress Syndrome/*physiopathology
PMC - PMC3013438
EDAT- 2010/12/15 06:00
MHDA- 2011/03/30 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/03/30 06:00 [medline]
AID - 366/1562/300 [pii]
AID - 10.1098/rstb.2010.0250 [doi]
PST - ppublish
SO  - Philos Trans R Soc Lond B Biol Sci. 2011 Jan 27;366(1562):300-5. doi:
      10.1098/rstb.2010.0250.


PMID- 21147422
OWN - NLM
STAT- MEDLINE
DCOM- 20110405
LR  - 20101214
IS  - 1532-9283 (Electronic)
IS  - 1360-8592 (Linking)
VI  - 15
IP  - 1
DP  - 2011 Jan
TI  - The effect of pelvic floor muscle exercise on women with chronic non-specific low
      back pain.
PG  - 75-81
LID - 10.1016/j.jbmt.2009.12.001 [doi]
AB  - Dysfunction of spinal stability seems to be one of the causes of low back pain
      (LBP). It is thought that a large number of muscles have a role in spinal
      stability including the pelvic floor muscle (PFM). The purpose of this study was 
      to investigate the effect of PFM exercise in the treatment of chronic LBP. After 
      ethical approval, a randomized controlled clinical trial was carried out on 20
      women with chronic LBP. Patients were randomly allocated into two groups: an
      experimental and a control group. The control group was given routine treatment
      including electrotherapy and general exercises; and the experimental group
      received routine treatment and additional PFM exercise. Pain intensity,
      functional disability and PFM strength and endurance were measured before,
      immediately after intervention and at 3 months follow-up. In both groups pain and
      functional disability were significantly reduced following treatment (p<0.01),
      but no significant difference was found between the two groups (p>0.05). All
      measurements were improved in both groups (p<0.01) although patients in the
      experimental group showed greater improvement in PFM strength and endurance
      (p<0.01). It seems that the PFM exercise combined with routine treatment was not 
      superior to routine treatment alone in patients with chronic LBP.
CI  - Copyright (c) 2009 Elsevier Ltd. All rights reserved.
FAU - Mohseni-Bandpei, Mohammad A
AU  - Mohseni-Bandpei MA
AD  - Physiotherapy Department, University of Social Welfare and Rehabilitation
      Sciences, PO Box 1985713834, Evin, Tehran, Iran. mohseni_bandpei@yahoo.com
FAU - Rahmani, Nahid
AU  - Rahmani N
FAU - Behtash, Hamid
AU  - Behtash H
FAU - Karimloo, Masoud
AU  - Karimloo M
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20091228
PL  - United States
TA  - J Bodyw Mov Ther
JT  - Journal of bodywork and movement therapies
JID - 9700068
SB  - IM
MH  - Adult
MH  - Chronic Disease
MH  - Exercise Therapy/*methods
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Low Back Pain/*rehabilitation
MH  - Middle Aged
MH  - *Pelvic Floor
EDAT- 2010/12/15 06:00
MHDA- 2011/04/06 06:00
CRDT- 2010/12/15 06:00
PHST- 2009/08/05 00:00 [received]
PHST- 2009/10/17 00:00 [revised]
PHST- 2009/12/08 00:00 [accepted]
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/04/06 06:00 [medline]
AID - S1360-8592(09)00162-4 [pii]
AID - 10.1016/j.jbmt.2009.12.001 [doi]
PST - ppublish
SO  - J Bodyw Mov Ther. 2011 Jan;15(1):75-81. doi: 10.1016/j.jbmt.2009.12.001. Epub
      2009 Dec 28.


PMID- 21144959
OWN - NLM
STAT- MEDLINE
DCOM- 20110419
LR  - 20161125
IS  - 1879-291X (Electronic)
IS  - 0301-5629 (Linking)
VI  - 37
IP  - 1
DP  - 2011 Jan
TI  - A preclinical in vivo investigation of high-intensity focused ultrasound combined
      with radiotherapy.
PG  - 69-77
LID - 10.1016/j.ultrasmedbio.2010.10.001 [doi]
AB  - This study aims to perform an in vivo investigation evaluating the injury to the 
      pancreas and adjacent tissue of swine resulting with high-intensity focused
      ultrasound (HIFU) combined with radiotherapy (RT). The protocol was approved by
      the animal ethics committee at the Peking University First Hospital. A total of
      12 domestic swine were divided into four groups: control, HIFU only, RT only and 
      HIFU + RT. The injury to the pancreas, adjacent tissue and tissue within the
      acoustic path of the HIFU beam was assessed based on gross and histologic
      findings. For the targeted region of the pancreas, the score of the combined
      group was higher than that of the HIFU group and there was significant
      difference. For the acoustic path tissue, there was no significant difference
      except between the control group and the other groups. HIFU combined with RT
      increased the injury to the targeted pancreas, without increased injury to tissue
      outside of the targeted region.
CI  - Copyright (c) 2011. Published by Elsevier Inc.
FAU - Liu, Chao-Xing
AU  - Liu CX
AD  - Department of Radiation Oncology, Peking University First Hospital, Beijing,
      China.
FAU - Gao, Xian-Shu
AU  - Gao XS
FAU - Xiong, Liu-Lin
AU  - Xiong LL
FAU - Ge, Hui-Yu
AU  - Ge HY
FAU - He, Xin-Yong
AU  - He XY
FAU - Li, Ting
AU  - Li T
FAU - Zhang, Hong-Juan
AU  - Zhang HJ
FAU - Bai, Hong-Zhong
AU  - Bai HZ
FAU - Lin, Qiang
AU  - Lin Q
FAU - Zhang, Ming
AU  - Zhang M
FAU - Zhao, Jing
AU  - Zhao J
FAU - Xiong, Wei
AU  - Xiong W
FAU - Bai, Yu
AU  - Bai Y
FAU - Asaumi, Junichi
AU  - Asaumi J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Ultrasound Med Biol
JT  - Ultrasound in medicine & biology
JID - 0410553
SB  - IM
MH  - Animals
MH  - High-Intensity Focused Ultrasound Ablation/*methods
MH  - Pancreas/*diagnostic imaging/*radiation effects
MH  - Particle Accelerators
MH  - Radiation Oncology
MH  - Random Allocation
MH  - Statistics, Nonparametric
MH  - Swine
MH  - Transducers
MH  - Ultrasonography
EDAT- 2010/12/15 06:00
MHDA- 2011/04/20 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/04/25 00:00 [received]
PHST- 2010/08/12 00:00 [revised]
PHST- 2010/10/03 00:00 [accepted]
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/04/20 06:00 [medline]
AID - S0301-5629(10)00533-8 [pii]
AID - 10.1016/j.ultrasmedbio.2010.10.001 [doi]
PST - ppublish
SO  - Ultrasound Med Biol. 2011 Jan;37(1):69-77. doi:
      10.1016/j.ultrasmedbio.2010.10.001.


PMID- 21143576
OWN - NLM
STAT- MEDLINE
DCOM- 20110408
LR  - 20220410
IS  - 1466-769X (Electronic)
IS  - 1466-7681 (Linking)
VI  - 12
IP  - 1
DP  - 2011 Jan
TI  - Nursing and justice as a basic human need.
PG  - 34-44
LID - 10.1111/j.1466-769X.2010.00459.x [doi]
AB  - This paper explores the idea that justice is a basic human need akin to those
      famously depicted in Maslow's hierarchy of human needs and, as such, warrants
      recognition as a core element in representative ideas about nursing. Early nurse 
      theorists positioned the principles and practice of nursing as having their
      origins in 'universal human needs'. The principle of deriving nursing care from
      human needs was thought to provide a guide not only for promoting health, but for
      preventing disease and illness. The nursing profession has had a longstanding
      commitment to social justice as a core professional value and ideal, obligating
      nurses to address the social conditions that undermine people's health. The idea 
      of justice as a universal human need per se and its possible relationship to
      people's health outcomes has, however, not been considered. One reason for this
      is that justice in nursing discourse has more commonly been associated with law
      and ethics, and the legal and ethical responsibilities of nurses in relation to
      individualized patient care and, more recently, changing systems of care to
      improve health and health outcomes. Although this association is not incorrect,
      it is incomplete. A key aim of this paper is to redress this oversight and to
      encourage a broader conceptualization of justice as necessary for human survival,
      health and development, not merely as a professional value, or legal or ethical
      principle for guiding human conduct.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Johnstone, Megan-Jane
AU  - Johnstone MJ
AD  - Deakin University, Melbourne, Victoria, Australia. megan.johnstone@deakin.edu.au
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Philos
JT  - Nursing philosophy : an international journal for healthcare professionals
JID - 100897394
SB  - IM
MH  - *Drive
MH  - Empathy
MH  - Ethical Theory
MH  - Health Services Needs and Demand/*ethics
MH  - Human Rights
MH  - Human Rights Abuses/ethics
MH  - Humanism
MH  - Humans
MH  - Nurse's Role
MH  - Nursing Theory
MH  - *Philosophy, Nursing
MH  - Principle-Based Ethics
MH  - Social Justice/*ethics
MH  - Social Values
EDAT- 2010/12/15 06:00
MHDA- 2011/04/09 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/04/09 06:00 [medline]
AID - 10.1111/j.1466-769X.2010.00459.x [doi]
PST - ppublish
SO  - Nurs Philos. 2011 Jan;12(1):34-44. doi: 10.1111/j.1466-769X.2010.00459.x.


PMID- 21142344
OWN - NLM
STAT- MEDLINE
DCOM- 20110920
LR  - 20110517
IS  - 1939-1854 (Electronic)
IS  - 0021-9010 (Linking)
VI  - 96
IP  - 3
DP  - 2011 May
TI  - Fostering good citizenship through ethical leadership: exploring the moderating
      role of gender and organizational politics.
PG  - 633-42
LID - 10.1037/a0021872 [doi]
AB  - Considering the implications of social exchange theory as a context for social
      role behavior, we tested relations between ethical leadership and both person-
      and task-focused organizational citizenship behavior and examined the roles
      played by employee gender and politics perceptions. Although social exchange
      theory predicts that ethical leadership is positively associated with
      citizenship, social role theory predicts that the nature of this relationship may
      vary on the basis of gender and politics perceptions. Results from data collected
      from 288 supervisor-subordinate dyads indicate that the pattern of male versus
      female employees' citizenship associated with ethical leadership depends
      significantly on their perceptions of politics. Implications for theory and
      practice are discussed.
FAU - Kacmar, K Michele
AU  - Kacmar KM
AD  - The University of Alabama, Management and Marketing Department, Culverhouse
      College of Commerce and Business Administration, Box 870225, Tuscaloosa, AL
      35487-0225, USA. mkacmar@cba.ua.edu
FAU - Bachrach, Daniel G
AU  - Bachrach DG
FAU - Harris, Kenneth J
AU  - Harris KJ
FAU - Zivnuska, Suzanne
AU  - Zivnuska S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Appl Psychol
JT  - The Journal of applied psychology
JID - 0222526
SB  - IM
MH  - Data Collection
MH  - *Ethics, Business
MH  - Female
MH  - Group Processes
MH  - Humans
MH  - *Leadership
MH  - Male
MH  - Middle Aged
MH  - *Organizational Culture
MH  - Perception
MH  - Role
MH  - Sex Factors
MH  - *Social Behavior
MH  - Workplace/organization & administration/psychology
EDAT- 2010/12/15 06:00
MHDA- 2011/09/21 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/09/21 06:00 [medline]
AID - 2010-25588-001 [pii]
AID - 10.1037/a0021872 [doi]
PST - ppublish
SO  - J Appl Psychol. 2011 May;96(3):633-42. doi: 10.1037/a0021872.


PMID- 21142339
OWN - NLM
STAT- MEDLINE
DCOM- 20110804
LR  - 20110322
IS  - 1939-1854 (Electronic)
IS  - 0021-9010 (Linking)
VI  - 96
IP  - 2
DP  - 2011 Mar
TI  - Thick as thieves: the effects of ethical orientation and psychological safety on 
      unethical team behavior.
PG  - 401-11
LID - 10.1037/a0021503 [doi]
AB  - The purpose of this study was to uncover compositional and emergent influences on
      unethical behavior by teams. Results from 126 teams indicated that the presence
      of a formalistic orientation within the team was negatively related to collective
      unethical decisions. Conversely, the presence of a utilitarian orientation within
      the team was positively related to both unethical decisions and behaviors.
      Results also indicated that the relationship between utilitarianism and unethical
      outcomes was moderated by the level of psychological safety within the team, such
      that teams with high levels of safety were more likely to engage in unethical
      behaviors. Implications are discussed, as well as potential directions for future
      research.
CI  - PsycINFO Database Record (c) 2011 APA, all rights reserved.
FAU - Pearsall, Matthew J
AU  - Pearsall MJ
AD  - Department of Management & Organization, Robert H. Smith School of Business,
      University of Maryland, College Park, MD 20742-1815, USA.
      mpearsall@rhsmith.umd.edu
FAU - Ellis, Aleksander P J
AU  - Ellis AP
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Appl Psychol
JT  - The Journal of applied psychology
JID - 0222526
SB  - IM
MH  - Adult
MH  - *Cooperative Behavior
MH  - Decision Making/*ethics
MH  - *Ethical Theory
MH  - Female
MH  - *Group Processes
MH  - Humans
MH  - Male
MH  - Social Behavior
MH  - Students/psychology
MH  - Theft/*ethics/*psychology
MH  - Young Adult
EDAT- 2010/12/15 06:00
MHDA- 2011/08/05 06:00
CRDT- 2010/12/15 06:00
PHST- 2010/12/15 06:00 [entrez]
PHST- 2010/12/15 06:00 [pubmed]
PHST- 2011/08/05 06:00 [medline]
AID - 2010-25582-001 [pii]
AID - 10.1037/a0021503 [doi]
PST - ppublish
SO  - J Appl Psychol. 2011 Mar;96(2):401-11. doi: 10.1037/a0021503.


PMID- 21139506
OWN - NLM
STAT- MEDLINE
DCOM- 20110509
LR  - 20220310
IS  - 1536-0210 (Electronic)
IS  - 0020-9996 (Linking)
VI  - 46
IP  - 2
DP  - 2011 Feb
TI  - Double-dose gadoxetic Acid-enhanced magnetic resonance imaging in patients with
      chronic liver disease.
PG  - 141-5
LID - 10.1097/RLI.0b013e3181f9c487 [doi]
AB  - OBJECTIVES: determine the effect of double-dose gadoxetic-acid (Gd-EOB-DTPA) on
      lesion-liver contrast ratio in arterial- and hepatocyte-phase images and
      arterial-phase image quality in patients with chronic liver disease. MATERIALS
      AND METHODS: the ethics committee at our institute approved this study. This
      study included 28 patients (13 with Child-Pugh class A and 15 with class B) with 
      54 hepatocellular carcinomas. All patients received the standard Gd-EOB-DTPA dose
      (0.025 mmol/kg bodyweight) and double dose (0.050 mmol/kg bodyweight). The
      lesion-liver contrast ratio was evaluated in arterial- and hepatocyte-phase
      images. The artifacts in arterial-phase images were evaluated with a 4-point
      scale. Wilcoxon signed-rank test were used for comparisons. RESULTS: the
      hepatocyte-phase lesion-liver contrast ratio after the double dose was
      significantly higher than that after the standard dose in patients with
      Child-Pugh class B disease(standard dose vs. double dose; 0.20 +/- 0.16 vs. 0.25 
      +/- 0.17; P < 0.0001); however, the ratio after both the standard and double
      doses was equivalent in patients with Child-Pugh class A disease (0.35 +/- 0.18
      vs. 0.35 +/- 0.14; P = 0.3038). The double dose significantly increased the
      arterial-phase lesion-liver contrast ratio (0.34 +/- 0.19 vs. 0.58 +/- 0.33; P < 
      0.0001). The artifacts in the arterial-phase images were more prominent after the
      standard dose (2.7 vs. 2.4 for reader 1, 2.8 vs. 2.4 for reader 2; P = 0.0195 and
      0.0010). CONCLUSIONS: administration of double dose of Gd-EOB-DTPA provided
      better arterial enhancement of hepatocellular carcinomas in patients with chronic
      liver disease, and also improved the lesion-liver contrast in hepatocyte-phase
      images in patients with Child-Pugh class B disease.
FAU - Motosugi, Utaroh
AU  - Motosugi U
AD  - First Department of Radiology, University of Yamanashi, Yamanashi, Japan.
FAU - Ichikawa, Tomoaki
AU  - Ichikawa T
FAU - Sano, Katsuhiro
AU  - Sano K
FAU - Sou, Hironobu
AU  - Sou H
FAU - Onohara, Kojiro
AU  - Onohara K
FAU - Muhi, Ali
AU  - Muhi A
FAU - Kitamura, Takatoshi
AU  - Kitamura T
FAU - Amemiya, Fumitake
AU  - Amemiya F
FAU - Enomoto, Nobuyuki
AU  - Enomoto N
FAU - Matsuda, Masanori
AU  - Matsuda M
FAU - Asakawa, Masami
AU  - Asakawa M
FAU - Fujii, Hideki
AU  - Fujii H
FAU - Araki, Tsutomu
AU  - Araki T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Invest Radiol
JT  - Investigative radiology
JID - 0045377
RN  - 0 (Contrast Media)
RN  - 0 (gadolinium ethoxybenzyl DTPA)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Aged
MH  - Carcinoma, Hepatocellular/*diagnosis/pathology
MH  - Chronic Disease
MH  - *Contrast Media/administration & dosage
MH  - Female
MH  - *Gadolinium DTPA/administration & dosage
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Liver Diseases/diagnosis/pathology
MH  - Liver Neoplasms/*diagnosis/pathology
MH  - Magnetic Resonance Imaging/*instrumentation/methods
MH  - Male
MH  - Statistics as Topic
MH  - Statistics, Nonparametric
MH  - Tomography, X-Ray Computed
EDAT- 2010/12/09 06:00
MHDA- 2011/05/10 06:00
CRDT- 2010/12/09 06:00
PHST- 2010/12/09 06:00 [entrez]
PHST- 2010/12/09 06:00 [pubmed]
PHST- 2011/05/10 06:00 [medline]
AID - 10.1097/RLI.0b013e3181f9c487 [doi]
PST - ppublish
SO  - Invest Radiol. 2011 Feb;46(2):141-5. doi: 10.1097/RLI.0b013e3181f9c487.


PMID- 21135610
OWN - NLM
STAT- MEDLINE
DCOM- 20110324
LR  - 20191210
IS  - 1538-8646 (Electronic)
IS  - 0730-4625 (Linking)
VI  - 30
IP  - 1
DP  - 2011 Jan-Feb
TI  - Personal reflection: critical-care visitation and the headache that follows.
PG  - 39-40
LID - 10.1097/DCC.0b013e3181fd0319 [doi]
AB  - Critical-care nurses, as well as other nurses, face ethical, moral, and legal
      issues often in their units. In some cases, the issue may cause conflict between 
      the patient, the patient's family, and health care providers, including nurses.
      One possible area of conflict is critical-care visitation. This article describes
      visitation in critical-care units as well as possible outcomes and solutions.
FAU - Chakma, Nijhenee
AU  - Chakma N
AD  - California State University, San Bernardino, USA. Nijhenee@yahoo.com
FAU - Ocampo, Justin-Paul
AU  - Ocampo JP
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Dimens Crit Care Nurs
JT  - Dimensions of critical care nursing : DCCN
JID - 8211489
MH  - Attitude of Health Personnel
MH  - Communication
MH  - Conflict, Psychological
MH  - Cooperative Behavior
MH  - *Critical Care/ethics/organization & administration/psychology
MH  - *Family/psychology
MH  - Humans
MH  - Nurse's Role/psychology
MH  - *Nursing Staff, Hospital/ethics/organization & administration/psychology
MH  - Organizational Policy
MH  - *Professional-Family Relations/ethics
MH  - *Visitors to Patients/legislation & jurisprudence/psychology
EDAT- 2010/12/08 06:00
MHDA- 2011/03/25 06:00
CRDT- 2010/12/08 06:00
PHST- 2010/12/08 06:00 [entrez]
PHST- 2010/12/08 06:00 [pubmed]
PHST- 2011/03/25 06:00 [medline]
AID - 10.1097/DCC.0b013e3181fd0319 [doi]
AID - 00003465-201101000-00008 [pii]
PST - ppublish
SO  - Dimens Crit Care Nurs. 2011 Jan-Feb;30(1):39-40. doi:
      10.1097/DCC.0b013e3181fd0319.


PMID- 21134626
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20191210
IS  - 1532-9496 (Electronic)
IS  - 0887-7963 (Linking)
VI  - 25
IP  - 1
DP  - 2011 Jan
TI  - Relative risk of reducing the lifetime blood donation deferral for men who have
      had sex with men versus currently tolerated transfusion risks.
PG  - 47-60
LID - 10.1016/j.tmrv.2010.08.006 [doi]
AB  - The risks of known and emerging transfusion-transmitted infections (TTIs) from
      reducing the current lifetime blood donation deferral for men who have had sex
      with men (MSM) to 1 or 5 years were compared to the risk from continuing to
      transfuse in the United States 12.5% of platelet doses as pooled
      whole-blood-derived (rather than single-donor) platelets. Assumptions made in
      mathematical models and blood donor/transfusion studies of the risks of TTIs
      since 2000 were evaluated. The number of HIV, hepatitis B virus, or hepatitis C
      virus TTIs from reducing the MSM deferral to 1 year is, respectively, 0.88, 2.94,
      or 66.9, many more than 10 times smaller than the risk from pooled platelets. If 
      erroneous release of HIV-positive units (a risk independent of a donor's source
      of infection) is not considered, the MSM risk is 1 HIV-infectious donation per 17
      to 56 million MSM donations. Any purportedly increased risk of human
      herpesvirus-8 transmission from MSM donors is far smaller than the risk of
      transfusion-associated sepsis from pooled platelets. Single-donor platelets from 
      MSM after 5 years' abstinence are as safe or 5 times safer than our current
      pooled platelets--if the next TTI to emerge were transmitted, respectively,
      sexually or by another route. Thus, acceptance of MSM as blood donors after 1 or 
      5 years' abstinence may result in a postulated increase in risk that is so much
      smaller than the currently tolerated transfusion risk and so small in absolute
      terms that the ethical question of fairness to the MSM group justifies the change
      in policy.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Vamvakas, Eleftherios C
AU  - Vamvakas EC
AD  - Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los
      Angeles, CA 90048, USA. vamvakase@cshs.org
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Transfus Med Rev
JT  - Transfusion medicine reviews
JID - 8709027
SB  - IM
MH  - Blood Donors/*legislation & jurisprudence
MH  - Blood Transfusion/*legislation & jurisprudence/standards
MH  - Donor Selection/*legislation & jurisprudence/methods
MH  - HIV Infections/etiology/transmission
MH  - *Homosexuality, Male
MH  - Humans
MH  - Male
MH  - Men
MH  - Risk
MH  - Risk Factors
MH  - Sexual Behavior/physiology
MH  - *Transfusion Reaction
MH  - United States
EDAT- 2010/12/08 06:00
MHDA- 2011/06/03 06:00
CRDT- 2010/12/08 06:00
PHST- 2010/12/08 06:00 [entrez]
PHST- 2010/12/08 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
AID - S0887-7963(10)00056-8 [pii]
AID - 10.1016/j.tmrv.2010.08.006 [doi]
PST - ppublish
SO  - Transfus Med Rev. 2011 Jan;25(1):47-60. doi: 10.1016/j.tmrv.2010.08.006.


PMID- 21131900
OWN - NLM
STAT- MEDLINE
DCOM- 20110307
LR  - 20110128
IS  - 1534-6080 (Electronic)
IS  - 0041-1337 (Linking)
VI  - 91
IP  - 3
DP  - 2011 Feb 15
TI  - Compatible-incompatible live donor kidney exchanges.
PG  - 257-60
LID - 10.1097/TP.0b013e3182047554 [doi]
AB  - The participation of an immunologically compatible donor-intended recipient pair 
      in a kidney exchange that is unnecessary for them can significantly increase the 
      number of kidneys available for transplantation. Despite their utilitarian value 
      transplant ethicists have condemned this type of organ exchange as morally
      inappropriate. An opposing analysis concludes that these exchanges are examples
      of moral excellence that should be encouraged.
FAU - Steinberg, David
AU  - Steinberg D
AD  - Section of Medical Ethics, Lahey Clinic, Burlington, MA 01805, USA.
      david.steinberg@lahey.org
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
SB  - IM
MH  - Blood Group Incompatibility/immunology
MH  - Coercion
MH  - Histocompatibility/*immunology
MH  - Humans
MH  - Kidney Failure, Chronic/surgery
MH  - Kidney Transplantation/*ethics/*immunology
MH  - Living Donors/*ethics
MH  - Tissue and Organ Procurement/ethics
EDAT- 2010/12/07 06:00
MHDA- 2011/03/08 06:00
CRDT- 2010/12/07 06:00
PHST- 2010/12/07 06:00 [entrez]
PHST- 2010/12/07 06:00 [pubmed]
PHST- 2011/03/08 06:00 [medline]
AID - 10.1097/TP.0b013e3182047554 [doi]
PST - ppublish
SO  - Transplantation. 2011 Feb 15;91(3):257-60. doi: 10.1097/TP.0b013e3182047554.


PMID- 21128760
OWN - NLM
STAT- MEDLINE
DCOM- 20110714
LR  - 20120425
IS  - 1545-2093 (Electronic)
IS  - 0163-7525 (Linking)
VI  - 32
DP  - 2011
TI  - Genetic susceptibility and the setting of occupational health standards.
PG  - 149-59
LID - 10.1146/annurev-publhealth-031210-101144 [doi]
AB  - As more is learned about genetic susceptibility to occupational and environmental
      hazards, there will be increasing pressure to use genetic susceptibility
      information in setting occupational health standards. Historically, this has not 
      been done, but a growing body of research assesses inherited genetic factors as
      modifiers of the effects of hazardous exposures. Additionally, acquired genetic
      and epigenetic characteristics could also be used in standard setting. However,
      for both inherited and acquired genetic characteristics, many scientific,
      ethical, legal, and social issues could arise. Investigators need to examine the 
      potential role and implications of using genetic information in standard setting.
      In this review, we focus primarily on inherited genetic factors and their role in
      occupational health standard setting.
FAU - Schulte, Paul
AU  - Schulte P
AD  - National Institute for Occupational Safety and Health, Centers for Disease
      Control and Prevention, Cincinnati, Ohio 45226, USA. pschulte@cdc.gov
FAU - Howard, John
AU  - Howard J
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Annu Rev Public Health
JT  - Annual review of public health
JID - 8006431
SB  - IM
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Occupational Exposure/*standards
MH  - *Occupational Health
EDAT- 2010/12/07 06:00
MHDA- 2011/07/16 06:00
CRDT- 2010/12/07 06:00
PHST- 2010/12/07 06:00 [entrez]
PHST- 2010/12/07 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
AID - 10.1146/annurev-publhealth-031210-101144 [doi]
PST - ppublish
SO  - Annu Rev Public Health. 2011;32:149-59. doi:
      10.1146/annurev-publhealth-031210-101144.


PMID- 21127437
OWN - NLM
STAT- MEDLINE
DCOM- 20110428
LR  - 20101223
IS  - 1556-1380 (Electronic)
IS  - 1556-0864 (Linking)
VI  - 6
IP  - 1
DP  - 2011 Jan
TI  - Maintenance therapy in advanced non-small cell lung cancer: current status and
      future implications.
PG  - 174-82
LID - 10.1097/JTO.0b013e318200f9c5 [doi]
AB  - Maintenance therapy for patients with advanced non-small cell lung cancer has
      been an area of intense investigation. Maintenance therapy has been divided into 
      two broad categories: continuation maintenance when the chemotherapy or targeted 
      agent was part of a defined number of cycles of combination therapy and in the
      absence of disease progression is continued as a single agent or switch
      maintenance when a third agent is initiated after four cycles of platinum-based
      double-agent chemotherapy in the absence of disease progression. Two monoclonal
      antibodies, cetuximab and bevacizumab, are used as continuation maintenance, but 
      the incremental benefit of the maintenance therapy with these agents is
      undetermined. Phase III trials have not revealed an overall survival benefit for 
      continuation maintenance chemotherapy, and this approach should be considered
      investigational. Phase III trials have demonstrated an improvement in overall
      survival with switch maintenance therapy with pemetrexed compared with placebo in
      patients with nonsquamous histology and erlotinib compared with placebo. Phase
      III trials have not revealed an improvement in quality of life with maintenance
      therapy. In the trials of maintenance therapy, 30 to 40% of patients enrolled in 
      the observation or placebo arm did not receive second-line therapy, and among the
      patients who did receive second-line therapy, there was significant heterogeneity
      in the therapy. The development of maintenance therapy has raised issues about
      the role of treatment-free intervals in routine clinical care, trial design
      issues such as the optimal endpoint, the ethics of a placebo arm, and the
      implications of maintenance therapy for first-line trials.
FAU - Stinchcombe, Thomas E
AU  - Stinchcombe TE
AD  - Lineberger Comprehensive Cancer Center at University of North Carolina, Chapel
      Hill, NC 27599-7305, USA. Thomas_Stinchcombe@med.unc.edu
FAU - Socinski, Mark A
AU  - Socinski MA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Thorac Oncol
JT  - Journal of thoracic oncology : official publication of the International
      Association for the Study of Lung Cancer
JID - 101274235
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Antineoplastic Agents/*therapeutic use
MH  - Carcinoma, Non-Small-Cell Lung/*drug therapy
MH  - *Clinical Trials as Topic
MH  - Humans
MH  - Lung Neoplasms/*drug therapy
EDAT- 2010/12/04 06:00
MHDA- 2011/04/29 06:00
CRDT- 2010/12/04 06:00
PHST- 2010/12/04 06:00 [entrez]
PHST- 2010/12/04 06:00 [pubmed]
PHST- 2011/04/29 06:00 [medline]
AID - 10.1097/JTO.0b013e318200f9c5 [doi]
AID - S1556-0864(15)31913-4 [pii]
PST - ppublish
SO  - J Thorac Oncol. 2011 Jan;6(1):174-82. doi: 10.1097/JTO.0b013e318200f9c5.


PMID- 21120621
OWN - NLM
STAT- MEDLINE
DCOM- 20110603
LR  - 20211020
IS  - 1573-0980 (Electronic)
IS  - 1386-7415 (Linking)
VI  - 32
IP  - 2
DP  - 2011 Apr
TI  - The force of dissimilar analogies in bioethics.
PG  - 117-28
LID - 10.1007/s11017-010-9165-6 [doi]
AB  - Although analogical reasoning has long been a popular method of reasoning in
      bioethics, current literature does not sufficiently grasp its variety. We assert 
      that the main shortcoming is the fact that an analogy's value is often judged on 
      the extent of similarity between the source situation and the target situation,
      while in (bio)ethics, analogies are often used because of certain dissimilarities
      rather than in spite of them. We make a clear distinction between dissimilarities
      that aim to reinforce a similar approach in the source situation and the target
      situation and dissimilarities that aim to undermine or denounce a similar
      approach. The former kind of dissimilarity offers the analogy more normative
      force than if there were no dissimilarities present; this is often overlooked by 
      authors who regard all relevant dissimilarities as detrimental to the analogy's
      strength. Another observation is that an evaluation of the normative force of an 
      analogy cannot be made independently of moral principles or theories. Without
      these, one cannot select which elements in an analogy are morally relevant nor
      determine how they should be interpreted.
FAU - Mertes, Heidi
AU  - Mertes H
AD  - Bioethics Institute Ghent, Blandijnberg 2, 9000, Ghent, Belgium.
      Heidi.Mertes@UGent.be
FAU - Pennings, Guido
AU  - Pennings G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Theor Med Bioeth
JT  - Theoretical medicine and bioethics
JID - 9805378
SB  - IM
MH  - *Bioethical Issues
MH  - Ethical Analysis
MH  - Humans
MH  - *Metaphor
MH  - *Morals
MH  - Oocyte Donation/economics/ethics
MH  - Problem Solving/*ethics
MH  - Stem Cell Research/economics/ethics
EDAT- 2010/12/02 06:00
MHDA- 2011/06/04 06:00
CRDT- 2010/12/02 06:00
PHST- 2010/12/02 06:00 [entrez]
PHST- 2010/12/02 06:00 [pubmed]
PHST- 2011/06/04 06:00 [medline]
AID - 10.1007/s11017-010-9165-6 [doi]
PST - ppublish
SO  - Theor Med Bioeth. 2011 Apr;32(2):117-28. doi: 10.1007/s11017-010-9165-6.


PMID- 21115537
OWN - NLM
STAT- MEDLINE
DCOM- 20110310
LR  - 20211020
IS  - 1471-2970 (Electronic)
IS  - 0962-8436 (Linking)
VI  - 366
IP  - 1561
DP  - 2011 Jan 12
TI  - Tragedy and delight: the ethics of decelerated ageing.
PG  - 108-12
LID - 10.1098/rstb.2010.0288 [doi]
AB  - Biogerontology is sometimes viewed as similar to other forms of biomedical
      research in that it seeks to understand and treat a pathological process. Yet the
      prospect of treating ageing is extraordinary in terms of the profound changes to 
      the human condition that would result. Recent advances in biogerontology allow a 
      clearer view of the ethical issues and dilemmas that confront humanity with
      respect to treating ageing. For example, they imply that organismal senescence is
      a disease process with a broad spectrum of pathological consequences in late life
      (causing or exascerbating cardiovascular disease, cancer, neurodegenerative
      disease and many others). Moreover, in laboratory animals, it is possible to
      decelerate ageing, extend healthy adulthood and reduce the age-incidence of a
      broad spectrum of ageing-related diseases. This is accompanied by an overall
      extension of lifespan, sometimes of a large magnitude. Discussions of the ethics 
      of treating ageing sometimes involve hand-wringing about detrimental consequences
      (e.g. to society) of marked life extension which, arguably, would be a form of
      enhancement technology. Yet given the great improvements in health that
      decelerated ageing could provide, it would seem that the only possible ethical
      course is to pursue it energetically. Thus, decelerated ageing has an element of 
      tragic inevitability: its benefits to health compel us to pursue it, despite the 
      transformation of human society, and even human nature, that this could entail.
FAU - Gems, David
AU  - Gems D
AD  - Institute of Healthy Ageing, and G.E.E., Darwin Building, University College
      London, Gower Street, London WC1E 6BT, UK. david.gems@ucl.ac.uk
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Philos Trans R Soc Lond B Biol Sci
JT  - Philosophical transactions of the Royal Society of London. Series B, Biological
      sciences
JID - 7503623
SB  - IM
MH  - Aged, 80 and over
MH  - Aging/*ethics/*physiology
MH  - Animals
MH  - Humans
MH  - Models, Animal
PMC - PMC3001315
EDAT- 2010/12/01 06:00
MHDA- 2011/03/11 06:00
CRDT- 2010/12/01 06:00
PHST- 2010/12/01 06:00 [entrez]
PHST- 2010/12/01 06:00 [pubmed]
PHST- 2011/03/11 06:00 [medline]
AID - 366/1561/108 [pii]
AID - 10.1098/rstb.2010.0288 [doi]
PST - ppublish
SO  - Philos Trans R Soc Lond B Biol Sci. 2011 Jan 12;366(1561):108-12. doi:
      10.1098/rstb.2010.0288.


PMID- 21107735
OWN - NLM
STAT- MEDLINE
DCOM- 20111201
LR  - 20211020
IS  - 1573-3394 (Electronic)
IS  - 1065-3058 (Linking)
VI  - 19
IP  - 1
DP  - 2011 Mar
TI  - Justice and proximity: problems for an ethics of care.
PG  - 3-14
LID - 10.1007/s10728-010-0159-3 [doi]
AB  - This paper aims at addressing some questions considering the conflicting
      normative claims of partiality, i.e. to provide for the caring needs of the
      particular patient, and impartial claims of treating all patients with a relevant
      need equally. This ethical conflict between different conceptions of moral
      responsibilities within professional ethics relates to debates between an ethics 
      of care and an ethics of justice. An ethics of care is a particularistic position
      that endorses some form of partiality, i.e. favouring persons to whom one stands 
      in particular relationships. This paper argues that also a professional ethics
      must endorse some kind of partiality at the clinical level of health care. In
      fact, consideration of care for particular patients is a prerequisite for giving 
      proper and attentive care towards the individual patient. This paper will discuss
      how partial concerns might be balanced against claims of distributive justice
      within the frame of the formal principle of justice. It is concluded that there
      is an urgent need for the recognition of the consequences of macro-level
      decisions for the possibility of the discharge of moral responsibility on a
      clinical level of health care. This would mean that health care institutions
      should adapt for the possibility of a basic standard of proper care and attention
      for the individual patient.
FAU - Nordhaug, Marita
AU  - Nordhaug M
AD  - Centre for the Study of Professions, Oslo University College, PO Box 4, St. Olavs
      Plass, 0130 Oslo, Norway. marita.nordhaug@hio.no
FAU - Nortvedt, Per
AU  - Nortvedt P
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Health Care Anal
JT  - Health care analysis : HCA : journal of health philosophy and policy
JID - 9432537
MH  - Decision Making/ethics
MH  - Delivery of Health Care/*ethics
MH  - *Ethics, Medical
MH  - *Ethics, Nursing
MH  - Humans
MH  - Moral Obligations
MH  - Patient Rights
EDAT- 2010/11/26 06:00
MHDA- 2011/12/13 00:00
CRDT- 2010/11/26 06:00
PHST- 2010/11/26 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/s10728-010-0159-3 [doi]
PST - ppublish
SO  - Health Care Anal. 2011 Mar;19(1):3-14. doi: 10.1007/s10728-010-0159-3.


PMID- 21088896
OWN - NLM
STAT- MEDLINE
DCOM- 20110829
LR  - 20220408
IS  - 1573-6571 (Electronic)
IS  - 0022-4197 (Linking)
VI  - 50
IP  - 2
DP  - 2011 Jun
TI  - The role of imams in American Muslim health: perspectives of Muslim community
      leaders in Southeast Michigan.
PG  - 359-73
LID - 10.1007/s10943-010-9428-6 [doi]
AB  - American Muslims are a diverse and growing population, numbering nearly 200,000
      in Southeast Michigan. Little empirical work exists on the influence of Islam
      upon the healthcare behaviors of American Muslims, and there is to date limited
      research on the roles that imams, Muslim religious leaders, play in the health of
      this community. Utilizing a community-based participatory research (CBPR) model
      through collaboration with four key community organizations, we conducted
      semi-structured interviews with 12 community leaders and explored their
      perceptions about the roles imams play in community health. Respondents
      identified four central roles for imams in healthcare: (1) encouraging healthy
      behaviors through scripture-based messages in sermons; (2) performing religious
      rituals around life events and illnesses; (3) advocating for Muslim patients and 
      delivering cultural sensitivity training in hospitals; and (4) assisting in
      healthcare decisions for Muslims. Our analysis also suggests several challenges
      for imams stemming from medical uncertainty and ethical conflicts. Imams play key
      roles in framing concepts of health and disease and encouraging healthy
      lifestyles outside of the healthcare system, as well as advocating for Muslim
      patient needs and aiding in healthcare decisions within the hospital. Healthcare 
      partnerships with these religious leaders and their institutions may be an
      important means to enhance the health of American Muslims.
FAU - Padela, Aasim I
AU  - Padela AI
AD  - Robert Wood Johnson Foundation Clinical Scholars Program, Department of General
      Internal Medicine, University of Michigan, 6312 Med Sci Bldg I, 1150 W. Med
      Center Dr, Ann Arbor, MI 48109-5604, USA. aasim@umich.edu
FAU - Killawi, Amal
AU  - Killawi A
FAU - Heisler, Michele
AU  - Heisler M
FAU - Demonner, Sonya
AU  - Demonner S
FAU - Fetters, Michael D
AU  - Fetters MD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Relig Health
JT  - Journal of religion and health
JID - 2985199R
SB  - IM
MH  - Adult
MH  - *Clergy
MH  - Data Collection
MH  - Female
MH  - Humans
MH  - Interviews as Topic
MH  - *Islam
MH  - Male
MH  - Michigan
MH  - Middle Aged
MH  - *Professional Role
MH  - Residence Characteristics
EDAT- 2010/11/23 06:00
MHDA- 2011/08/30 06:00
CRDT- 2010/11/20 06:00
PHST- 2010/11/20 06:00 [entrez]
PHST- 2010/11/23 06:00 [pubmed]
PHST- 2011/08/30 06:00 [medline]
AID - 10.1007/s10943-010-9428-6 [doi]
PST - ppublish
SO  - J Relig Health. 2011 Jun;50(2):359-73. doi: 10.1007/s10943-010-9428-6.


PMID- 21088815
OWN - NLM
STAT- MEDLINE
DCOM- 20111118
LR  - 20211020
IS  - 1433-0385 (Electronic)
IS  - 0009-4722 (Linking)
VI  - 82
IP  - 6
DP  - 2011 Jun
TI  - [Jehova's Witnesses and severe injury with impending hemorrhaging : how complex
      is the treatment?].
PG  - 531-5
LID - 10.1007/s00104-010-1999-y [doi]
AB  - Hemorrhage is frequently seen during the early phases of polytrauma management
      and intensive care treatment of the severely injured. Traumatic coagulopathy as
      well as the sometimes overlooked hyperfibrinolysis may lead to further
      complications. Therefore, transfusion of blood products and coagulation factors
      is often crucial. Jehova's Witnesses reject transfusions of blood and blood
      products due to religious convictions. In this case report a therapeutic approach
      of a multiple trauma patient suffering from traumatic brain injury, blunt chest
      trauma and liver laceration is described, who has been treated without blood
      products. As one main focus, ethical as well as legal aspects are discussed.
      Beside therapeutic concepts, such as the administration of coagulation factors,
      recombinant erythropoietin and iron, ethical and legal aspects remain part of the
      controversial discussion.
FAU - Zeckey, C
AU  - Zeckey C
AD  - Unfallchirurgische Klinik, Medizinische Hochschule Hannover, Deutschland.
      Zeckey.Christian@mh-hannover.de
FAU - Vanin, N
AU  - Vanin N
FAU - Neitzke, G
AU  - Neitzke G
FAU - Mommsen, P
AU  - Mommsen P
FAU - Bachmann, S
AU  - Bachmann S
FAU - Frink, M
AU  - Frink M
FAU - Wilhelmi, M
AU  - Wilhelmi M
FAU - Krettek, C
AU  - Krettek C
FAU - Hildebrand, F
AU  - Hildebrand F
LA  - ger
PT  - Case Reports
PT  - Journal Article
TT  - Zeugen Jehovas und Schwerverletzung mit drohender Hamorrhagie : Wie komplex ist
      die Behandlung?
PL  - Germany
TA  - Chirurg
JT  - Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
JID - 16140410R
RN  - 0 (Blood Coagulation Factors)
RN  - 11096-26-7 (Erythropoietin)
SB  - IM
MH  - Algorithms
MH  - Blood Coagulation Factors/administration & dosage
MH  - *Blood Transfusion
MH  - Brain Injuries/*diagnosis/surgery
MH  - Contraindications
MH  - Contusions/diagnosis/therapy
MH  - Critical Care/methods
MH  - Erythropoietin/administration & dosage
MH  - Female
MH  - Hemorrhage/diagnosis/*therapy
MH  - Hemostatic Techniques
MH  - Humans
MH  - *Jehovah's Witnesses
MH  - Liver/*injuries
MH  - Lung Injury/*diagnosis
MH  - Multiple Trauma/diagnosis/*therapy
MH  - *Religion and Medicine
MH  - Rupture
MH  - Spleen/*injuries
MH  - Tomography, X-Ray Computed
MH  - Trauma Centers
MH  - Ultrasonography
MH  - Young Adult
EDAT- 2010/11/23 06:00
MHDA- 2011/12/13 00:00
CRDT- 2010/11/20 06:00
PHST- 2010/11/20 06:00 [entrez]
PHST- 2010/11/23 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/s00104-010-1999-y [doi]
PST - ppublish
SO  - Chirurg. 2011 Jun;82(6):531-5. doi: 10.1007/s00104-010-1999-y.


PMID- 21088598
OWN - NLM
STAT- MEDLINE
DCOM- 20110520
LR  - 20181201
IS  - 1365-2346 (Electronic)
IS  - 0265-0215 (Linking)
VI  - 28
IP  - 2
DP  - 2011 Feb
TI  - A randomised trial comparing sufentanil versus remifentanil for laparoscopic
      gastroplasty in the morbidly obese patient.
PG  - 120-4
LID - 10.1097/EJA.0b013e3283405048 [doi]
AB  - BACKGROUND AND OBJECTIVE: This prospective, randomised double-blind study
      compared the effects of target control infusion (TCI) of sufentanil and
      remifentanil on the quality of recovery and post-operative pain control in
      morbidly obese patients undergoing laparoscopic gastroplasty. METHODS: Following 
      institutional Ethics Committee approval and written informed consent, 100
      morbidly obese patients were randomised to receive either TCI sufentanil (0.3 ng 
      ml(-)(1); S-group; N = 50) or TCI remifentanil (3 ng ml(-)(1); R-group; N = 50)
      in combination with desflurane (O(2)/air mixture: FiO(2), 50%). Quality of
      recovery was estimated by means of the modified Aldrete score and by the ability 
      to perform psychomotor tests with the same competence post-operatively as
      pre-operatively. Post-operative pain was evaluated by the quantity of piritramide
      needed to achieve a visual analogue scale (VAS) less than 3. Statistical analysis
      was performed using an unpaired Student's t-test, Mann-Whitney U-test and chi(2) 
      test, as appropriate. RESULTS: Patient and surgical characteristics were similar 
      among groups. In the R-group, time to extubation was significantly shorter, but
      VAS significantly higher than that in the S-group (P < 0.01). Quality of recovery
      and duration of post-anaesthesia care unit stay were comparable between groups
      (S-group: 119 +/- 27 min and R-group: 119 +/- 35 min). Piritramide consumption
      during the first 4 post-operative hours was higher in the R-group than in the
      S-group [S-group (median, range): 11.5 mg, 5.5-16.0; R-group: 18.0 mg, 14-22, P <
      0.01], but not later on. CONCLUSION: In the conditions of the present study,
      although TCI sufentanil resulted in slower awakening than TCI remifentanil, it
      was associated with a better quality of recovery.
FAU - Bidgoli, Javad
AU  - Bidgoli J
AD  - Department of Anesthesiology, Centre Hospitalo-Universitaire Brugmann, Free
      University of Brussels, Belgium, The Netherlands.
FAU - Delesalle, Sophie
AU  - Delesalle S
FAU - De Hert, Stefan G
AU  - De Hert SG
FAU - Reiles, Eric
AU  - Reiles E
FAU - Van der Linden, Philippe J
AU  - Van der Linden PJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur J Anaesthesiol
JT  - European journal of anaesthesiology
JID - 8411711
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Piperidines)
RN  - 4RP92LYZ2F (Pirinitramide)
RN  - AFE2YW0IIZ (Sufentanil)
RN  - P10582JYYK (Remifentanil)
SB  - IM
MH  - Adult
MH  - Analgesics, Opioid/administration & dosage/therapeutic use
MH  - Anesthesia Recovery Period
MH  - Female
MH  - Gastroplasty/*methods
MH  - Humans
MH  - Laparoscopy/methods
MH  - Male
MH  - Middle Aged
MH  - Obesity, Morbid/*surgery
MH  - Pain Measurement
MH  - Pain, Postoperative/drug therapy/*prevention & control
MH  - Piperidines/administration & dosage/*therapeutic use
MH  - Pirinitramide/administration & dosage/therapeutic use
MH  - Psychomotor Performance
MH  - Remifentanil
MH  - Sufentanil/administration & dosage/*therapeutic use
MH  - Time Factors
EDAT- 2010/11/20 06:00
MHDA- 2011/05/21 06:00
CRDT- 2010/11/20 06:00
PHST- 2010/11/20 06:00 [entrez]
PHST- 2010/11/20 06:00 [pubmed]
PHST- 2011/05/21 06:00 [medline]
AID - 10.1097/EJA.0b013e3283405048 [doi]
PST - ppublish
SO  - Eur J Anaesthesiol. 2011 Feb;28(2):120-4. doi: 10.1097/EJA.0b013e3283405048.


PMID- 21076806
OWN - NLM
STAT- MEDLINE
DCOM- 20110517
LR  - 20211020
IS  - 1433-0407 (Electronic)
IS  - 0028-2804 (Linking)
VI  - 82
IP  - 1
DP  - 2011 Jan
TI  - [Physician-assisted suicide in dementia?].
PG  - 50-6
LID - 10.1007/s00115-010-3182-6 [doi]
AB  - Physician-assisted suicide in Germany is limited by criminal law and disapproved 
      by professional authorities. A physician who is willing to help a demented
      patient in terminating his life has to be definitely sure that the disease does
      not interfere with the patient's capacity for decision-making. In cases of early 
      dementia the reason why assisted suicide will usually be requested is not the
      actual suffering of the patient but his negative expectations for the future. As 
      long as there are sufficient opportunities for palliative care, the progressive
      course of the dementia process does not imply a state of unbearable suffering
      which could justify an assisted suicide. Nevertheless there may be certain
      circumstances--as for instance the value that an individual attributes to his
      integrity or to the narrative unity of his life--which might possibly provide an 
      ethical justification for the assistance in life termination. A physician who
      helps a demented person in performing a suicidal act does not necessarily oppose 
      essential principles of medical ethics. Yet, especially with regard to possible
      societal consequences of physician-assisted suicide in dementia, the rejecting
      attitude of medical authorities against that activity must be considered as well 
      founded and legitimate. Deviations from these general guidelines ought to be
      respected as long as they are limited to exceptional situations and correspond to
      a thorough consideration of a physician's professional duties. They should remain
      open to public control, but not be ultimately specified by unequivocal normative 
      regulations.
FAU - Lauter, H
AU  - Lauter H
AD  - Beltweg 6, Munich, Germany. hanslauter@t-online.de
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Arztliche Suizidassistenz bei Demenzerkrankungen?
PL  - Germany
TA  - Nervenarzt
JT  - Der Nervenarzt
JID - 0400773
SB  - IM
MH  - Dementia/*diagnosis/*psychology
MH  - Germany
MH  - Humans
MH  - Informed Consent/*ethics/*legislation & jurisprudence
MH  - Physician-Patient Relations/*ethics
MH  - Suicide, Assisted/*ethics/*legislation & jurisprudence
EDAT- 2010/11/16 06:00
MHDA- 2011/05/18 06:00
CRDT- 2010/11/16 06:00
PHST- 2010/11/16 06:00 [entrez]
PHST- 2010/11/16 06:00 [pubmed]
PHST- 2011/05/18 06:00 [medline]
AID - 10.1007/s00115-010-3182-6 [doi]
PST - ppublish
SO  - Nervenarzt. 2011 Jan;82(1):50-6. doi: 10.1007/s00115-010-3182-6.


PMID- 21074702
OWN - NLM
STAT- MEDLINE
DCOM- 20110114
LR  - 20101115
IS  - 1558-4232 (Electronic)
IS  - 1094-9194 (Linking)
VI  - 14
IP  - 1
DP  - 2011 Jan
TI  - Pain and nociception in reptiles.
PG  - 45-60
LID - 10.1016/j.cvex.2010.09.009 [doi]
AB  - The ability of reptiles to "feel" pain and the significance of pain or
      nociception on physiologic homeostasis is an exceedingly complex question
      requiring integration of both physiologic and behavioral evidence. Until further 
      information is available, it would seem most ethical for veterinarians to assume 
      that reptiles are capable of feeling pain, and to treat or manage pain when there
      is reasonable evidence that pain is present. With increased information available
      regarding analgesic use in reptiles and with the heightened awareness of the
      importance of analgesia for zoologic companion animals, it is likely that more
      veterinarians will provide pain relief to their reptile patients.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Mosley, Craig
AU  - Mosley C
AD  - Department of Anesthesia, Canada West Veterinary Specialists, 1988 Kootenay
      Street, Vancouver, British Columbia V5M 4Y3, Canada. c.mosley96@yahoo.ca
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Vet Clin North Am Exot Anim Pract
JT  - The veterinary clinics of North America. Exotic animal practice
JID - 9815628
RN  - 0 (Analgesics)
SB  - IM
MH  - Analgesia/*veterinary
MH  - Analgesics/*therapeutic use
MH  - Animals
MH  - Nociceptors/*physiology
MH  - Pain/prevention & control/*veterinary
MH  - Reptiles/*physiology
EDAT- 2010/11/16 06:00
MHDA- 2011/01/15 06:00
CRDT- 2010/11/16 06:00
PHST- 2010/11/16 06:00 [entrez]
PHST- 2010/11/16 06:00 [pubmed]
PHST- 2011/01/15 06:00 [medline]
AID - S1094-9194(10)00125-8 [pii]
AID - 10.1016/j.cvex.2010.09.009 [doi]
PST - ppublish
SO  - Vet Clin North Am Exot Anim Pract. 2011 Jan;14(1):45-60. doi:
      10.1016/j.cvex.2010.09.009.


PMID- 21074699
OWN - NLM
STAT- MEDLINE
DCOM- 20110114
LR  - 20101115
IS  - 1558-4232 (Electronic)
IS  - 1094-9194 (Linking)
VI  - 14
IP  - 1
DP  - 2011 Jan
TI  - Clinical interpretation of pharmacokinetic and pharmacodynamic data in zoologic
      companion animal species.
PG  - 1-20
LID - 10.1016/j.cvex.2010.09.006 [doi]
AB  - The treatment and prevention of pain in zoologic companion animals is difficult
      because of the lack of data available on the safety and efficacy of analgesics.
      Pharmacokinetic (PK)-pharmacodynamic (PD) studies integrate changes in drug
      concentrations and changes in the drug's effect. All experimental studies
      assessing the PDs of analgesics have limitations in animals, but the data
      provided by experimental studies are valuable in designing dosages.
      Placebo-controlled, randomized, and blinded clinical trials provide the best PK
      and PD data, but are rarely performed in major veterinary species because of the 
      number of animals required for the study, lack of preliminary PK and PD data in a
      given species, species-specific differences in PK and PD, and ethical and
      toxicologic concerns. The usefulness and limitations as well as considerations
      for interpreting PK, PD, and controlled clinical studies are discussed. An
      example of allometric analysis of buprenorphine in mammals is also included.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Kukanich, Butch
AU  - Kukanich B
AD  - College of Veterinary Medicine, Kansas State University, 228 Coles Hall,
      Manhattan, KS 66506-5802, USA. kukanich@ksu.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Vet Clin North Am Exot Anim Pract
JT  - The veterinary clinics of North America. Exotic animal practice
JID - 9815628
RN  - 0 (Analgesics)
RN  - 0 (Veterinary Drugs)
SB  - IM
MH  - Analgesia/*veterinary
MH  - Analgesics/*pharmacokinetics/*pharmacology
MH  - Animals
MH  - Clinical Trials as Topic
MH  - Dose-Response Relationship, Drug
MH  - Drug Evaluation
MH  - Models, Animal
MH  - Models, Biological
MH  - Pain/prevention & control/*veterinary
MH  - Pain Measurement/veterinary
MH  - Species Specificity
MH  - Veterinary Drugs/pharmacokinetics/pharmacology
EDAT- 2010/11/16 06:00
MHDA- 2011/01/15 06:00
CRDT- 2010/11/16 06:00
PHST- 2010/11/16 06:00 [entrez]
PHST- 2010/11/16 06:00 [pubmed]
PHST- 2011/01/15 06:00 [medline]
AID - S1094-9194(10)00122-2 [pii]
AID - 10.1016/j.cvex.2010.09.006 [doi]
PST - ppublish
SO  - Vet Clin North Am Exot Anim Pract. 2011 Jan;14(1):1-20. doi:
      10.1016/j.cvex.2010.09.006.


PMID- 21068671
OWN - NLM
STAT- MEDLINE
DCOM- 20111118
LR  - 20220210
IS  - 1530-0366 (Electronic)
IS  - 1098-3600 (Linking)
VI  - 13
IP  - 1
DP  - 2011 Jan
TI  - Unleashing the power of human genetic variation knowledge: New Zealand
      stakeholder perspectives.
PG  - 26-38
LID - 10.1097/GIM.0b013e3181f9648a [doi]
AB  - PURPOSE: This study aimed to characterize the challenges in using genetic
      information in health care and to identify opportunities for improvement.
      METHODS: Taking a grounded theory approach, semistructured interviews were
      conducted with 48 participants to collect multiple stakeholder perspectives on
      genetic services in New Zealand. RESULTS: Three themes emerged from the data: (1)
      four service delivery models were identified in operation, including both those
      expected models involving genetic counselors and variations that do not route
      through the formal genetic service program; (2) multiple barriers to sharing and 
      using genetic information were perceived, including technological,
      organizational, institutional, legal, ethical, and social issues; and (3)
      impediments to wider use of genetic testing technology, including variable
      understanding of genetic test utilities among clinicians and the limited capacity
      of clinical genetic services. Targeting these problems, information technologies 
      and knowledge management tools have the potential to support key tasks in genetic
      services delivery, improve knowledge processes, and enhance knowledge networks.
      CONCLUSION: Because of the effect of issues in genetic information and knowledge 
      management, the potential of human genetic variation knowledge to enhance health 
      care delivery has been put on a "leash."
FAU - Gu, Yulong
AU  - Gu Y
AD  - Department of Computer Science - Tamaki, University of Auckland, Private Bag
      92019, Auckland, New Zealand. ygu029@cs.auckland.ac.nz
FAU - Warren, James Roy
AU  - Warren JR
FAU - Day, Karen Jean
AU  - Day KJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genet Med
JT  - Genetics in medicine : official journal of the American College of Medical
      Genetics
JID - 9815831
SB  - IM
MH  - Delivery of Health Care/legislation & jurisprudence/standards
MH  - Genetic Testing/legislation & jurisprudence/statistics & numerical data
MH  - *Genetic Variation
MH  - *Health Knowledge, Attitudes, Practice
MH  - Health Services Accessibility
MH  - Humans
MH  - Interviews as Topic
MH  - Knowledge Management/statistics & numerical data
MH  - New Zealand
EDAT- 2010/11/12 06:00
MHDA- 2011/12/13 00:00
CRDT- 2010/11/12 06:00
PHST- 2010/11/12 06:00 [entrez]
PHST- 2010/11/12 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1097/GIM.0b013e3181f9648a [doi]
AID - S1098-3600(21)04047-8 [pii]
PST - ppublish
SO  - Genet Med. 2011 Jan;13(1):26-38. doi: 10.1097/GIM.0b013e3181f9648a.


PMID- 21057317
OWN - NLM
STAT- MEDLINE
DCOM- 20110207
LR  - 20220309
IS  - 1530-0293 (Electronic)
IS  - 0090-3493 (Linking)
VI  - 39
IP  - 1
DP  - 2011 Jan
TI  - Partial do-not-resuscitate orders: A hazard to patient safety and clinical
      outcomes?
PG  - 14-8
LID - 10.1097/CCM.0b013e3181feb8f6 [doi]
AB  - BACKGROUND: Patients and families commonly discuss end-of-life decisions with
      clinicians to create a treatment plan based on patient wishes. In some instances,
      respect for patient autonomy in making choices may create the potential for
      patient harm. Medical treatments are often performed in groupings in order to
      work effectively. When such combinations are separated as a result of patient or 
      surrogate choices, critical elements of life- saving care may be omitted, and the
      patient may receive nonbeneficial or harmful treatment. A partial
      do-not-resuscitate order may serve as an example. LITERATURE REVIEW AND
      DISCUSSION: The limited literature available regarding partial do-not-resuscitate
      order(s) suggests the practice is clinically and ethically problematic. Not much 
      is known about the prevalence of these orders, but some clinicians believe they
      are a growing phenomenon. Medical and bioethics organizations have produced
      guidelines and recommendations on the use of full do-not-resuscitate order(s)
      with little mention of partial do-not-resuscitate order(s). Partial
      do-not-resuscitate order(s) are designed based on the patient's anticipated need 
      for resuscitation and are intended to manage dying in a tolerable manner based on
      what the decision maker believes is "best." Through an analysis of the medical
      literature, we propose that a partial do-not-resuscitate order contradicts this
      "best" management intention because it is impossible for the decision maker, or
      care providers, to anticipate all possible prearrest and arrest situations. We
      propose that a partial do-not-resuscitate order highlights larger problems: 1) a 
      misunderstanding of the meaning and scope of a do-not-resuscitate order and 2) a 
      need for discussions around goals of care. CONCLUSION: Discouraging partial
      do-not-resuscitate(s) order may help promote more accurate and comprehensive
      advance care planning.
FAU - Sanders, Alan
AU  - Sanders A
AD  - Center for Ethics (AS), Saint Joseph's Hospital, Atlanta, GA, USA.
      alansanders@sjha.org
FAU - Schepp, Melissa
AU  - Schepp M
FAU - Baird, Marianne
AU  - Baird M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Crit Care Med
JT  - Critical care medicine
JID - 0355501
SB  - IM
CIN - Crit Care Med. 2011 Jan;39(1):193-4. PMID: 21178531
MH  - *Advance Care Planning
MH  - Cardiopulmonary Resuscitation/trends
MH  - Decision Making
MH  - Family Relations
MH  - Female
MH  - Heart Arrest/mortality/*therapy
MH  - Humans
MH  - Informed Consent
MH  - Life Support Care/trends
MH  - Male
MH  - Resuscitation Orders/*ethics
MH  - Risk Assessment
MH  - Safety Management
MH  - United States
EDAT- 2010/11/09 06:00
MHDA- 2011/02/08 06:00
CRDT- 2010/11/09 06:00
PHST- 2010/11/09 06:00 [entrez]
PHST- 2010/11/09 06:00 [pubmed]
PHST- 2011/02/08 06:00 [medline]
AID - 10.1097/CCM.0b013e3181feb8f6 [doi]
PST - ppublish
SO  - Crit Care Med. 2011 Jan;39(1):14-8. doi: 10.1097/CCM.0b013e3181feb8f6.


PMID- 21053084
OWN - NLM
STAT- MEDLINE
DCOM- 20110603
LR  - 20191210
IS  - 1573-0980 (Electronic)
IS  - 1386-7415 (Linking)
VI  - 32
IP  - 2
DP  - 2011 Apr
TI  - Narrative responsibility and moral dilemma: A case study of a family's decision
      about a brain-dead daughter.
PG  - 91-9
LID - 10.1007/s11017-010-9160-y [doi]
AB  - A brain death case is presented and reinterpreted using the narrative approach.
      In the case, two Japanese parents face a dilemma about whether to respect their
      daughter's desire to donate organs even though, for them, it would mean literally
      killing their daughter. We argue that the ethical dilemma occurred because the
      parents were confronted with two conflicting narratives to which they felt a
      "narrative responsibility," namely, the responsibility that drives us to tell,
      retell, and coauthor the (often unfinished) narratives of loved ones. We suggest 
      that moral dilemmas arise not only from conflicts between moral justifications
      but also from conflicts between narratives and human relationships.
FAU - Kinjo, Takanobu
AU  - Kinjo T
AD  - Division of Community-based Medicine and Primary Care, Ryukyu University
      Hospital, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903-0215,
      Japan. takakinjo@gmail.com
FAU - Morioka, Masahiro
AU  - Morioka M
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Theor Med Bioeth
JT  - Theoretical medicine and bioethics
JID - 9805378
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Brain Death/diagnosis
MH  - Choice Behavior/ethics
MH  - *Conflict, Psychological
MH  - Decision Making/*ethics
MH  - Female
MH  - Humans
MH  - Japan
MH  - *Moral Obligations
MH  - Morals
MH  - *Narration
MH  - Nuclear Family
MH  - *Parents/psychology
MH  - Social Responsibility
MH  - Tissue and Organ Harvesting/*ethics
MH  - Tissue and Organ Procurement/*ethics
EDAT- 2010/11/06 06:00
MHDA- 2011/06/04 06:00
CRDT- 2010/11/06 06:00
PHST- 2010/11/06 06:00 [entrez]
PHST- 2010/11/06 06:00 [pubmed]
PHST- 2011/06/04 06:00 [medline]
AID - 10.1007/s11017-010-9160-y [doi]
PST - ppublish
SO  - Theor Med Bioeth. 2011 Apr;32(2):91-9. doi: 10.1007/s11017-010-9160-y.


PMID- 21052846
OWN - NLM
STAT- MEDLINE
DCOM- 20111201
LR  - 20211020
IS  - 1573-3394 (Electronic)
IS  - 1065-3058 (Linking)
VI  - 19
IP  - 1
DP  - 2011 Mar
TI  - Navigating in the landscape of care: a critical reflection on theory and practise
      of care and ethics.
PG  - 41-50
LID - 10.1007/s10728-010-0157-5 [doi]
AB  - The theory and practise of care is defined and enacted differently in different
      national as well as cultural contexts, illuminating how differently constructed
      the personal and societal structures in Europe are. A common trait is however
      that care work paid or non-paid, private or public is identified with women. To
      navigate in the landscape of care and ethics requires taking into account the
      constitutive relation between one's identity, embodiment and position. The author
      suggests conceiving care as an existential condition of life demanded from all
      human beings. This will free care from the identification with women and pave a
      way towards a more gender equal and just society with less gender segregation in 
      the labour market and at the arena of education.
FAU - Skaerbaek, Eva
AU  - Skaerbaek E
AD  - Ostfold University College, 1757 Halden, Norway. eva.skarbak@hiof.no
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Health Care Anal
JT  - Health care analysis : HCA : journal of health philosophy and policy
JID - 9432537
MH  - Delivery of Health Care/*ethics
MH  - Europe
MH  - Female
MH  - *Gender Identity
MH  - Humans
MH  - Male
MH  - Women
PMC - PMC3037487
EDAT- 2010/11/06 06:00
MHDA- 2011/12/13 00:00
CRDT- 2010/11/06 06:00
PHST- 2010/11/06 06:00 [entrez]
PHST- 2010/11/06 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/s10728-010-0157-5 [doi]
PST - ppublish
SO  - Health Care Anal. 2011 Mar;19(1):41-50. doi: 10.1007/s10728-010-0157-5.


PMID- 21052822
OWN - NLM
STAT- MEDLINE
DCOM- 20110425
LR  - 20211020
IS  - 1573-2770 (Electronic)
IS  - 0091-0562 (Linking)
VI  - 47
IP  - 1-2
DP  - 2011 Mar
TI  - Interdisciplinary linkage of community psychology and cross-cultural psychology: 
      history, values, and an illustrative research and action project on intimate
      partner violence.
PG  - 127-43
LID - 10.1007/s10464-010-9377-y [doi]
AB  - An analysis of the respective organizational histories, missions, and scholarly
      activity of the International Association for Cross-Cultural Psychology and the
      Society for Community Research and Action was conducted in order to inform the
      development of interdisciplinary linkages between members of the two
      organizations. The analysis revealed many points of shared values and actions, as
      well as some important differences. Both scholarly organizations developed out of
      a similar historical and cultural zeitgeist in the late 1960s and early 1970s.
      The missions emphasize the role of culture/diversity in psychological phenomena, 
      adopting an interdisciplinary orientation, the value of collaboration, the
      importance of research method and ethics, and the value of action research.
      However, community psychology generally lacks an adequate treatment of cultural
      phenomena while cross-cultural psychology often fails to draw on community and
      participatory methods useful for understanding culture in context. These common
      roots and differences are examined. Finally, we describe a community based,
      participatory research and intervention project to address intimate partner
      violence among Latinos and European-Americans living in Oregon. Analysis of the
      research process and on some of our initial findings illustrates challenges and
      potential benefits of an interdisciplinary, cultural community psychology.
FAU - Mankowski, Eric S
AU  - Mankowski ES
AD  - Department of Psychology, Portland State University, OR 97207-0751, USA.
      mankowskie@pdx.edu
FAU - Galvez, Gino
AU  - Galvez G
FAU - Glass, Nancy
AU  - Glass N
LA  - eng
GR  - L30 EY015681/EY/NEI NIH HHS/United States
GR  - R01 NR08771-01A1/NR/NINR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - Am J Community Psychol
JT  - American journal of community psychology
JID - 0364535
SB  - IM
MH  - Behavioral Research/methods
MH  - Cross-Cultural Comparison
MH  - Domestic Violence/ethnology/*psychology
MH  - Female
MH  - Humans
MH  - *Interdisciplinary Studies
MH  - Male
MH  - Mexican Americans/psychology
MH  - *Psychology, Social/methods
MH  - *Residence Characteristics
MH  - Workplace/psychology
EDAT- 2010/11/06 06:00
MHDA- 2011/04/26 06:00
CRDT- 2010/11/06 06:00
PHST- 2010/11/06 06:00 [entrez]
PHST- 2010/11/06 06:00 [pubmed]
PHST- 2011/04/26 06:00 [medline]
AID - 10.1007/s10464-010-9377-y [doi]
PST - ppublish
SO  - Am J Community Psychol. 2011 Mar;47(1-2):127-43. doi: 10.1007/s10464-010-9377-y.


PMID- 21044013
OWN - NLM
STAT- MEDLINE
DCOM- 20110902
LR  - 20190918
IS  - 1873-4316 (Electronic)
IS  - 1389-2010 (Linking)
VI  - 12
IP  - 2
DP  - 2011 Feb 1
TI  - Cell reprogramming: a new chemical approach to stem cell biology and tissue
      regeneration.
PG  - 146-50
AB  - Generation of pluripotent stem cells (iPSCs) from adult fibroblasts starts a "new
      era" in stem cell biology, as it overcomes several key issues associated with
      previous approaches, including the ethical concerns associated with human
      embryonic stem cells. However, as the genetic approach for cell reprogramming has
      already shown potential safety issues, a chemical approach may be a safer and
      easier alternative. Moreover, a chemical approach could be advantageous not only 
      for the de-differentiation phase, but also for inducing reprogrammed cells into
      the desired cell type with higher efficiency than current methodologies. Finally,
      a chemical approach may be envisioned to activate resident adult stem cells to
      proliferate and regenerate damaged tissues in situ, without the need for
      exogenous cell injections.
FAU - Anastasia, L
AU  - Anastasia L
AD  - Department of Medical Chemistry, Biochemistry and Biotechnology, University of
      Milan, Milan, Italy. luigi.anastasia@unimi.it
FAU - Piccoli, M
AU  - Piccoli M
FAU - Garatti, A
AU  - Garatti A
FAU - Conforti, E
AU  - Conforti E
FAU - Scaringi, R
AU  - Scaringi R
FAU - Bergante, S
AU  - Bergante S
FAU - Castelvecchio, S
AU  - Castelvecchio S
FAU - Venerando, B
AU  - Venerando B
FAU - Menicanti, L
AU  - Menicanti L
FAU - Tettamanti, G
AU  - Tettamanti G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Curr Pharm Biotechnol
JT  - Current pharmaceutical biotechnology
JID - 100960530
SB  - IM
MH  - Adult Stem Cells/cytology/*physiology
MH  - Cell Differentiation
MH  - *Cellular Reprogramming
MH  - Embryonic Stem Cells/cytology/physiology
MH  - Fibroblasts/cytology/physiology
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*physiology
MH  - Phenotype
MH  - Pluripotent Stem Cells/cytology/*physiology
MH  - *Regeneration
MH  - Stem Cells/cytology/*physiology
EDAT- 2010/11/04 06:00
MHDA- 2011/09/03 06:00
CRDT- 2010/11/04 06:00
PHST- 2010/06/20 00:00 [received]
PHST- 2010/07/20 00:00 [accepted]
PHST- 2010/11/04 06:00 [entrez]
PHST- 2010/11/04 06:00 [pubmed]
PHST- 2011/09/03 06:00 [medline]
AID - BSP/CPB/E-Pub/00036-12-4 [pii]
AID - 10.2174/138920111794295828 [doi]
PST - ppublish
SO  - Curr Pharm Biotechnol. 2011 Feb 1;12(2):146-50. doi: 10.2174/138920111794295828.


PMID- 21042830
OWN - NLM
STAT- MEDLINE
DCOM- 20120131
LR  - 20211020
IS  - 1618-727X (Electronic)
IS  - 0897-1889 (Linking)
VI  - 24
IP  - 5
DP  - 2011 Oct
TI  - Development of a research dedicated archival system (TARAS) in a university
      hospital.
PG  - 864-73
LID - 10.1007/s10278-010-9350-1 [doi]
AB  - Recent healthcare policies have influenced the manner in which patient data is
      handled in research projects, and the regulations concerning protected health
      information have become significantly tighter. Thus, new procedures are needed to
      facilitate research while protecting the confidentiality of patient data and
      ensuring the integrity of clinical work in the expanding environment of
      electronic files and databases. We have addressed this problem in a university
      hospital setting by developing the Tampere Research Archival System (TARAS), an
      extensive data warehouse for research purposes. This dynamic system includes
      numerous integrated and pseudonymized imaging studies and clinical data. In a
      pilot study on asthma patients, we tested and improved the functionality of the
      data archival system. TARAS is feasible to use in retrieving, analyzing, and
      processing both image and non-image data. In this paper, we present a detailed
      workflow of the implementation process of the data warehouse, paying special
      attention to administrative, ethical, practical, and data security concerns. The 
      establishment of TARAS will enhance and accelerate research practice at Tampere
      University Hospital, while also improving the safety of patient information as
      well as the prospects for national and international research collaboration. We
      hope that much can be learned from our experience of planning, designing, and
      implementing a research data warehouse combining imaging studies and medical
      records in a university hospital.
FAU - Rajala, Tiina
AU  - Rajala T
AD  - Medical Imaging Centre, Tampere University Hospital and University of Tampere, PL
      2000, 33521 Tampere, Finland. tiina.h.rajala@uta.fi
FAU - Savio, Sami
AU  - Savio S
FAU - Penttinen, Jarkko
AU  - Penttinen J
FAU - Dastidar, Prasun
AU  - Dastidar P
FAU - Kahonen, Mika
AU  - Kahonen M
FAU - Eskola, Hannu
AU  - Eskola H
FAU - Miettunen, Risto
AU  - Miettunen R
FAU - Turjanmaa, Vaino
AU  - Turjanmaa V
FAU - Jarvenpaa, Ritva
AU  - Jarvenpaa R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Digit Imaging
JT  - Journal of digital imaging
JID - 9100529
SB  - IM
MH  - *Hospitals, University
MH  - Humans
MH  - *Information Storage and Retrieval
MH  - Research Design/trends
PMC - PMC3180537
EDAT- 2010/11/03 06:00
MHDA- 2012/02/01 06:00
CRDT- 2010/11/03 06:00
PHST- 2010/11/03 06:00 [entrez]
PHST- 2010/11/03 06:00 [pubmed]
PHST- 2012/02/01 06:00 [medline]
AID - 10.1007/s10278-010-9350-1 [doi]
PST - ppublish
SO  - J Digit Imaging. 2011 Oct;24(5):864-73. doi: 10.1007/s10278-010-9350-1.


PMID- 20978437
OWN - NLM
STAT- MEDLINE
DCOM- 20110729
LR  - 20110812
IS  - 1538-9774 (Electronic)
IS  - 1538-2931 (Linking)
VI  - 29
IP  - 4
DP  - 2011 Apr
TI  - Comparing the teaching-learning process with and without the use of computerized 
      technological resources.
PG  - 212-20
LID - 10.1097/NCN.0b013e3181f9dcb5 [doi]
AB  - Computerized technological resources have become essential in education,
      particularly for teaching topics that require the performance of specific tasks. 
      These resources can effectively help the execution of such tasks and the
      teaching-learning process itself. After the development of a Web site on the
      topic of nursing staff scheduling, this study aimed at comparing the development 
      of students involved in the teaching-learning process of the previously mentioned
      topic, with and without the use of computer technology. Two random groups of
      undergraduate nursing students from a public university in Sao Paulo state,
      Brazil, were organized: a case group (used the Web site) and a control group (did
      not use the Web site). Data were collected from 2003 to 2005 after approval by
      the Research Ethics Committee. Results showed no significant difference in
      motivation or knowledge acquisition. A similar performance for the two groups was
      also verified. Other aspects observed were difficulty in doing the nursing staff 
      scheduling exercise and the students' acknowledgment of the topic's importance
      for their training and professional lives; easy access was considered to be a
      positive aspect for maintaining the Web site.
FAU - Juliani, Carmen Maria Casquel Monti
AU  - Juliani CM
AD  - Department of Nursing, Botucatu School of Medicine, Sao Paulo State University,
      UNESP, Brazil. cjuliani@fmb.unesp.br
FAU - Corrente, Jose Eduardo
AU  - Corrente JE
FAU - Dell'Acqua, Magda Cristina Queiroz
AU  - Dell'Acqua MC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Comput Inform Nurs
JT  - Computers, informatics, nursing : CIN
JID - 101141667
SB  - IM
RPI - Comput Inform Nurs. 2011 Jun;29(6 Suppl):TC89-97. PMID: 21701277
MH  - Case-Control Studies
MH  - *Computer-Assisted Instruction
MH  - Humans
MH  - *Learning
MH  - *Teaching
EDAT- 2010/10/28 06:00
MHDA- 2011/07/30 06:00
CRDT- 2010/10/28 06:00
PHST- 2010/10/28 06:00 [entrez]
PHST- 2010/10/28 06:00 [pubmed]
PHST- 2011/07/30 06:00 [medline]
AID - 10.1097/NCN.0b013e3181f9dcb5 [doi]
PST - ppublish
SO  - Comput Inform Nurs. 2011 Apr;29(4):212-20. doi: 10.1097/NCN.0b013e3181f9dcb5.


PMID- 20975553
OWN - NLM
STAT- MEDLINE
DCOM- 20110207
LR  - 20161125
IS  - 1530-0293 (Electronic)
IS  - 0090-3493 (Linking)
VI  - 39
IP  - 1
DP  - 2011 Jan
TI  - Does triage to critical care during a pandemic necessarily result in more
      survivors?
PG  - 179-83
LID - 10.1097/CCM.0b013e3181fa3c3b [doi]
AB  - OBJECTIVE: The 2009 H1N1 pandemic reinforced the need for a planned response to
      increased demand for critical care. Triage protocols have been proposed
      incorporating the exclusion of specified subgroups of patients from critical
      care. There have been no studies that explore the theoretical underpinning of
      triage at referral, and it is not clear under what circumstances triage would
      confer the intended benefits. We sought to explore the mechanisms whereby triage 
      could lead to fewer deaths across a critical care population in the context of a 
      pandemic. DESIGN: We constructed a mathematical model based on queuing theory to 
      compare the estimated short-term survival achieved by using a critical care
      service with and without triage at referral. Illustrative scenarios concerning a 
      hypothetical critical care population were constructed to explore the roles of
      length of stay and critical care survival in determining the impact of triage and
      to identify "tipping points" of demand at which triage would result in more
      survivors. SETTING: Not applicable as this was a data-free mathematical modeling 
      exercise. MAIN RESULTS: We identified circumstances in which triage would be
      expected to result in more survivors and circumstances in which it would not. In 
      some scenarios, excluding patient groups solely on the basis of anticipated
      length of stay could be effective due to a more efficient use of critical care
      bed days. CONCLUSIONS: The impact of triage is dependent on the level of demand
      and on the scale of achievable differences between included and excluded groups
      in terms of anticipated length of stay and critical care survival. It cannot be
      assumed that triage can or will result in fewer deaths. It should be remembered
      that there are considerations other than population-level short-term survival
      when determining the objectives of triage and its ethical implementation.
FAU - Utley, Martin
AU  - Utley M
AD  - Clinical Operational Research Unit, University College London, London, United
      Kingdom. m.utley@ucl.ac.uk
FAU - Pagel, Christina
AU  - Pagel C
FAU - Peters, Mark J
AU  - Peters MJ
FAU - Petros, Andy
AU  - Petros A
FAU - Lister, Paula
AU  - Lister P
LA  - eng
GR  - 0270036/Department of Health/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Crit Care Med
JT  - Critical care medicine
JID - 0355501
SB  - IM
MH  - Cause of Death
MH  - Critical Care/*methods
MH  - Critical Illness/mortality/therapy
MH  - Female
MH  - Health Planning/organization & administration
MH  - *Hospital Mortality
MH  - Humans
MH  - Influenza A Virus, H1N1 Subtype/isolation & purification
MH  - Influenza, Human/*diagnosis/*mortality/therapy
MH  - Intensive Care Units
MH  - Length of Stay
MH  - Male
MH  - Models, Theoretical
MH  - Pandemics/*statistics & numerical data
MH  - Reference Values
MH  - Referral and Consultation/statistics & numerical data
MH  - Survival Analysis
MH  - Time Factors
MH  - *Triage
MH  - United Kingdom
EDAT- 2010/10/27 06:00
MHDA- 2011/02/08 06:00
CRDT- 2010/10/27 06:00
PHST- 2010/10/27 06:00 [entrez]
PHST- 2010/10/27 06:00 [pubmed]
PHST- 2011/02/08 06:00 [medline]
AID - 10.1097/CCM.0b013e3181fa3c3b [doi]
PST - ppublish
SO  - Crit Care Med. 2011 Jan;39(1):179-83. doi: 10.1097/CCM.0b013e3181fa3c3b.


PMID- 20975549
OWN - NLM
STAT- MEDLINE
DCOM- 20110304
LR  - 20211020
IS  - 1530-0293 (Electronic)
IS  - 0090-3493 (Linking)
VI  - 39
IP  - 2
DP  - 2011 Feb
TI  - Informed consent in research to improve the number and quality of deceased donor 
      organs.
PG  - 280-3
LID - 10.1097/CCM.0b013e3181feeb04 [doi]
AB  - Improving the management of potential organ donors in the intensive care unit
      could meet an important public health goal by increasing the number and quality
      of transplantable organs. However, randomized clinical trials are needed to
      quantify the extent to which specific interventions might enhance organ recovery 
      and outcomes among transplant recipients. Among several barriers to conducting
      such studies are the absence of guidelines for obtaining informed consent for
      such studies and the fact that deceased organ donors are not covered by extant
      federal regulations governing oversight of research with human subjects. This
      article explores the underexamined ethical issues that arise in the context of
      donor management studies and provides ethical guidelines and suggested regulatory
      oversight mechanisms to enable such studies to be conducted ethically. We
      conclude that both the respect that is traditionally accorded to the prior wishes
      of the dead and the possibility of postmortem harm support a role for surrogate
      consent of donors in such randomized controlled trials. Furthermore, although
      recipients will often be considered human subjects under federal regulations,
      several ethical arguments support waiving requirements for recipient consent in
      donor management randomized controlled trials. Finally, we suggest that new
      regulatory mechanisms, perhaps linked to existing regional and national organ
      donation and transplantation infrastructures, must be established to protect
      patients in donor management studies while limiting unnecessary barriers to the
      conduct of this important research.
FAU - Rey, Michael M
AU  - Rey MM
AD  - University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
FAU - Ware, Lorraine B
AU  - Ware LB
FAU - Matthay, Michael A
AU  - Matthay MA
FAU - Bernard, Gordon R
AU  - Bernard GR
FAU - McGuire, Amy L
AU  - McGuire AL
FAU - Caplan, Arthur L
AU  - Caplan AL
FAU - Halpern, Scott D
AU  - Halpern SD
LA  - eng
GR  - R01 HL087115/HL/NHLBI NIH HHS/United States
GR  - HL088263/HL/NHLBI NIH HHS/United States
GR  - HL081619/HL/NHLBI NIH HHS/United States
GR  - R01 HL088263/HL/NHLBI NIH HHS/United States
GR  - R01 HL081619/HL/NHLBI NIH HHS/United States
GR  - HL087115/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Crit Care Med
JT  - Critical care medicine
JID - 0355501
SB  - IM
CIN - Crit Care Med. 2011 Feb;39(2):400-1. PMID: 21248520
CIN - Crit Care Med. 2011 Jun;39(6):1605-6; author replay 1606. PMID: 21610653
MH  - Biomedical Research/*ethics
MH  - Cadaver
MH  - Critical Illness/mortality
MH  - Female
MH  - Humans
MH  - Informed Consent/*ethics/*legislation & jurisprudence
MH  - Intensive Care Units
MH  - Male
MH  - Needs Assessment
MH  - Organ Transplantation/ethics/legislation & jurisprudence
MH  - Presumed Consent/ethics/legislation & jurisprudence
MH  - Randomized Controlled Trials as Topic
MH  - Tissue Donors/*ethics/legislation & jurisprudence/*supply & distribution
MH  - Tissue and Organ Procurement/ethics/legislation &
      jurisprudence/methods/*organization & administration
MH  - Total Quality Management
MH  - United States
PMC - PMC3717371
MID - NIHMS476591
EDAT- 2010/10/27 06:00
MHDA- 2011/03/05 06:00
CRDT- 2010/10/27 06:00
PHST- 2010/10/27 06:00 [entrez]
PHST- 2010/10/27 06:00 [pubmed]
PHST- 2011/03/05 06:00 [medline]
AID - 10.1097/CCM.0b013e3181feeb04 [doi]
PST - ppublish
SO  - Crit Care Med. 2011 Feb;39(2):280-3. doi: 10.1097/CCM.0b013e3181feeb04.


PMID- 20972646
OWN - NLM
STAT- MEDLINE
DCOM- 20110503
LR  - 20211020
IS  - 1556-0961 (Electronic)
IS  - 1541-6933 (Linking)
VI  - 14
IP  - 1
DP  - 2011 Feb
TI  - Metabolic and clinical effects of the supplementation of a functional mixture of 
      amino acids in cerebral hemorrhage.
PG  - 44-9
LID - 10.1007/s12028-010-9461-z [doi]
AB  - BACKGROUND: Oral supplementation of a specific mixture of essential and
      non-essential amino acids has been shown to modulate hypercatabolism in patients 
      with chronic heart failure, leading to improved clinical outcome. The aim of this
      study was to test whether such effects could be replicated in an acute clinical
      model of hypercatabolism. METHODS: After approval by the Ethics Committee,
      patients with acute brain hemorrhage admitted to the Neurosurgical ICU were
      randomly assigned to receive enterally for 14 days 20% of their estimated
      nitrogen requirements as a standard protein supplement (control group; n = 9) or 
      as a functional amino acid mixture (Aminotrofic(R), Errekappa Euroterapici; study
      group; n = 10). Metabolic and clinical outcome measures were monitored. RESULTS: 
      In the study group, insulin sensitivity and total lymphocyte count appeared to
      improve when compared with control patients. Less positive blood cultures were
      found in the study group against control patients (4 vs. 7, respectively; P =
      0.05). Also, mortality in the study group was reduced than in control patients
      (60 vs. 77%; P = n.s.). CONCLUSIONS: Supplementation with specific amino acids in
      critically ill patients may modulate metabolic response and improve clinical
      outcome.
FAU - Laviano, Alessandro
AU  - Laviano A
AD  - Department of Clinical Medicine, Sapienza University, Rome, Italy.
      alessandro.laviano@uniroma1.it
FAU - Aghilone, Flavia
AU  - Aghilone F
FAU - Colagiovanni, Donato
AU  - Colagiovanni D
FAU - Fiandra, Federica
AU  - Fiandra F
FAU - Giambarresi, Roberta
AU  - Giambarresi R
FAU - Tordiglione, Paolo
AU  - Tordiglione P
FAU - Molfino, Alessio
AU  - Molfino A
FAU - Muscaritoli, Maurizio
AU  - Muscaritoli M
FAU - Rosa, Giovanni
AU  - Rosa G
FAU - Rossi Fanelli, Filippo
AU  - Rossi Fanelli F
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Neurocrit Care
JT  - Neurocritical care
JID - 101156086
RN  - 0 (Amino Acids)
SB  - IM
MH  - Acute Disease
MH  - Administration, Oral
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Amino Acids/*administration & dosage
MH  - Brain/*drug effects/metabolism
MH  - Cerebral Hemorrhage/*drug therapy/metabolism/mortality
MH  - Critical Care/*methods
MH  - Energy Metabolism/*drug effects
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Morbidity
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2010/10/26 06:00
MHDA- 2011/05/04 06:00
CRDT- 2010/10/26 06:00
PHST- 2010/10/26 06:00 [entrez]
PHST- 2010/10/26 06:00 [pubmed]
PHST- 2011/05/04 06:00 [medline]
AID - 10.1007/s12028-010-9461-z [doi]
PST - ppublish
SO  - Neurocrit Care. 2011 Feb;14(1):44-9. doi: 10.1007/s12028-010-9461-z.


PMID- 20972530
OWN - NLM
STAT- MEDLINE
DCOM- 20110622
LR  - 20170916
IS  - 1433-0385 (Electronic)
IS  - 0009-4722 (Linking)
VI  - 82
IP  - 1
DP  - 2011 Jan
TI  - [Are specialists in ethics necessary in daily routine surgery?].
PG  - 80
LID - 10.1007/s00104-010-1995-2 [doi]
FAU - Gemsenjager, E
AU  - Gemsenjager E
LA  - ger
PT  - Comment
PT  - Letter
TT  - Sind Ethikfachleute im chirurgischen Alltag notwendig?
PL  - Germany
TA  - Chirurg
JT  - Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
JID - 16140410R
SB  - IM
CON - Chirurg. 2010 Jul;81(7):643-6. PMID: 20437024
MH  - Aged
MH  - Clinical Competence
MH  - Colon/surgery
MH  - Cooperative Behavior
MH  - Dementia/*diagnosis
MH  - Diagnosis, Differential
MH  - *Ethicists
MH  - *Ethics, Medical
MH  - *Frail Elderly
MH  - Germany
MH  - Humans
MH  - Ileus/*diagnosis/*surgery
MH  - Interdisciplinary Communication
MH  - Intuition
MH  - Jejunum/surgery
MH  - Medical Futility/*ethics
MH  - Peritoneal Neoplasms/*diagnosis/*surgery
MH  - Postoperative Complications/etiology
EDAT- 2010/10/26 06:00
MHDA- 2011/06/23 06:00
CRDT- 2010/10/26 06:00
PHST- 2010/10/26 06:00 [entrez]
PHST- 2010/10/26 06:00 [pubmed]
PHST- 2011/06/23 06:00 [medline]
AID - 10.1007/s00104-010-1995-2 [doi]
PST - ppublish
SO  - Chirurg. 2011 Jan;82(1):80. doi: 10.1007/s00104-010-1995-2.


PMID- 20971502
OWN - NLM
STAT- MEDLINE
DCOM- 20110503
LR  - 20150616
IS  - 1474-547X (Electronic)
IS  - 0140-6736 (Linking)
VI  - 377
IP  - 9775
DP  - 2011 Apr 23
TI  - "Gratuities" for donated organs: ethically indefensible.
PG  - 1390-1
LID - 10.1016/S0140-6736(10)61419-5 [doi]
FAU - Biller-Andorno, Nikola
AU  - Biller-Andorno N
AD  - Institute of Biomedical Ethics, University of Zurich, Zurich, Switzerland.
FAU - Capron, Alexander Morgan
AU  - Capron AM
LA  - eng
PT  - Journal Article
PL  - England
TA  - Lancet
JT  - Lancet (London, England)
JID - 2985213R
SB  - IM
MH  - *Bioethical Issues
MH  - *Commerce/economics/ethics
MH  - *Developing Countries
MH  - Humans
MH  - Medical Tourism/economics/*ethics/legislation & jurisprudence
MH  - Tissue and Organ Procurement/economics/*ethics/legislation & jurisprudence
EDAT- 2010/10/26 06:00
MHDA- 2011/05/04 06:00
CRDT- 2010/10/26 06:00
PHST- 2010/10/26 06:00 [entrez]
PHST- 2010/10/26 06:00 [pubmed]
PHST- 2011/05/04 06:00 [medline]
AID - S0140-6736(10)61419-5 [pii]
AID - 10.1016/S0140-6736(10)61419-5 [doi]
PST - ppublish
SO  - Lancet. 2011 Apr 23;377(9775):1390-1. doi: 10.1016/S0140-6736(10)61419-5.


PMID- 20963635
OWN - NLM
STAT- MEDLINE
DCOM- 20110420
LR  - 20110103
IS  - 1572-8633 (Electronic)
IS  - 1386-7423 (Linking)
VI  - 14
IP  - 1
DP  - 2011 Feb
TI  - Why should we respect the privacy of donors of biological material?
PG  - 43-52
LID - 10.1007/s11019-010-9292-x [doi]
AB  - Why should we respect the privacy of donors of biological material? The question 
      is answered in the present article in general philosophical terms from the point 
      of view of an ethics of honour, a libertarian theory of rights, a view of respect
      for privacy based on the idea that autonomy is of value in itself, and
      utilitarianism respectively. For different reasons the ethics of honour and the
      idea of the value of autonomy are set to one side. It surfaces that the moral
      rights theory and utilitarianism present conflicting answers to the question. The
      main thrust of the argument is that there is no way of finding an overlapping
      consensus, so politicians have to take decisions that are bound to be
      controversial in that they can be questioned on reasonable philosophical grounds.
FAU - Tannsjo, Torbjorn
AU  - Tannsjo T
AD  - Department of Philosophy, Stockholm University, 106 91, Stockholm, Sweden.
      torbjorn.tannsjo@philosophy.su.se
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Med Health Care Philos
JT  - Medicine, health care, and philosophy
JID - 9815900
SB  - IM
MH  - Confidentiality/*ethics
MH  - Forensic Genetics/ethics
MH  - Genes/ethics
MH  - Humans
MH  - Informed Consent/*ethics/standards
MH  - Ownership/ethics
MH  - *Personal Autonomy
MH  - Tissue Donors/*ethics
EDAT- 2010/10/22 06:00
MHDA- 2011/04/22 06:00
CRDT- 2010/10/22 06:00
PHST- 2010/10/22 06:00 [entrez]
PHST- 2010/10/22 06:00 [pubmed]
PHST- 2011/04/22 06:00 [medline]
AID - 10.1007/s11019-010-9292-x [doi]
PST - ppublish
SO  - Med Health Care Philos. 2011 Feb;14(1):43-52. doi: 10.1007/s11019-010-9292-x.


PMID- 20949396
OWN - NLM
STAT- MEDLINE
DCOM- 20110128
LR  - 20131121
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Linking)
VI  - 675
DP  - 2011
TI  - Cervical cytology biobanks as a resource for molecular epidemiology.
PG  - 279-98
LID - 10.1007/978-1-59745-423-0_15 [doi]
AB  - A cervical cytology biobank (CCB) is an extension of current cytopathology
      laboratory practice consisting in the systematic storage of Pap smears or
      liquid-based cytology samples from women participating in cervical cancer
      screening with the explicit purpose of facilitating future scientific research
      and quality audit of preventive services. A CCB should use an internationally
      agreed uniform cytology terminology, be integrated in a national or regional
      screening registry, and linked to other registries (histology, cancer, and
      vaccination). Legal and ethical principles concerning personal integrity and data
      safety must be respected strictly. Biobank-based studies require approval from
      ethical review boards. A CCB constitutes a nearly inexhaustible resource to
      perform fundamental and applied biologic research. In particular, it can
      contribute in answering questions on the natural history of HPV infection and
      HPV-induced lesions and cancers, screening effectiveness, exploration of new
      biomarkers, and surveillance of short- and long-term effects of the introduction 
      of HPV vaccination. To understand the limitations of CCB, more studies are needed
      on quality of samples in relation to sample type, storage procedures, and
      duration of storage.
FAU - Arbyn, Marc
AU  - Arbyn M
AD  - Unit of Cancer Epidemiology, Scientific Institute of Public Health, Brussels,
      Belgium. marc.arbyn@iph.fgov.be
FAU - Andersson, Kristin
AU  - Andersson K
FAU - Bergeron, Christine
AU  - Bergeron C
FAU - Bogers, John-Paul
AU  - Bogers JP
FAU - von Knebel-Doebertitz, Magnus
AU  - von Knebel-Doebertitz M
FAU - Dillner, Joakim
AU  - Dillner J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
SB  - IM
MH  - *Biological Specimen Banks
MH  - Cervix Uteri/*cytology/virology
MH  - Female
MH  - Humans
MH  - Molecular Epidemiology/*methods
MH  - Papanicolaou Test
MH  - Papillomavirus Infections/diagnosis
MH  - Vaginal Smears
EDAT- 2010/10/16 06:00
MHDA- 2011/02/01 06:00
CRDT- 2010/10/16 06:00
PHST- 2010/10/16 06:00 [entrez]
PHST- 2010/10/16 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
AID - 10.1007/978-1-59745-423-0_15 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2011;675:279-98. doi: 10.1007/978-1-59745-423-0_15.


PMID- 20949385
OWN - NLM
STAT- MEDLINE
DCOM- 20110128
LR  - 20101015
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Linking)
VI  - 675
DP  - 2011
TI  - Biobanks collected for routine healthcare purposes: build-up and use for
      epidemiologic research.
PG  - 113-25
LID - 10.1007/978-1-59745-423-0_4 [doi]
AB  - The routine health services collect large amount of samples for biobanking,
      particularly in clinical laboratory medicine, mainly for clinical diagnostic
      purposes. These samples provide a large-scale and clinically relevant biobanking 
      infrastructure that can be used for research if these conditions apply. There
      must be a system for database management that can obtain data on clinical
      endpoints, vital status, and additional required information via registry
      linkages. There must be an appropriate ethical system for handling consent for
      research use. There should be an active effort to optimize the usefulness of
      clinical biobanks also for research use. Major steps in this direction include
      measures to stop the ongoing discarding of old samples, reformatting to minimize 
      pick-up times, external quality assurance and formal accreditation of biobanks,
      building of a dedicated high-quality database that is regularly used for registry
      linkages, and considerations on whether usefulness and accessibility for research
      can be optimized by extended saving or pre-treatment of samples. Systematic
      clinical biobanking could become a major asset for clinical research and public
      health if biobanking is considered as a routine part of everyday clinical
      practice, and the science of biobanking is considered an essential part of the
      science of laboratory medicine.
FAU - Dillner, Joakim
AU  - Dillner J
AD  - Bio Banking and Molecular Resource, Infrastructure of Sweden (BBMRIse),
      Karolinska Institutet, Stockholm, Sweden.
FAU - Andersson, Kristin
AU  - Andersson K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
SB  - IM
MH  - Biological Specimen Banks/*ethics
MH  - *Epidemiologic Studies
MH  - Finland
MH  - Humans
MH  - Neoplasms/epidemiology
MH  - Registries
EDAT- 2010/10/16 06:00
MHDA- 2011/02/01 06:00
CRDT- 2010/10/16 06:00
PHST- 2010/10/16 06:00 [entrez]
PHST- 2010/10/16 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
AID - 10.1007/978-1-59745-423-0_4 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2011;675:113-25. doi: 10.1007/978-1-59745-423-0_4.


PMID- 20949383
OWN - NLM
STAT- MEDLINE
DCOM- 20110128
LR  - 20101015
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Linking)
VI  - 675
DP  - 2011
TI  - The need to downregulate: a minimal ethical framework for biobank research.
PG  - 39-59
LID - 10.1007/978-1-59745-423-0_2 [doi]
AB  - There are currently multiple international bodies suggesting legal and ethical
      frameworks for regulating international biobank research. One will for obvious
      reasons find inconsistencies in terminology and differences in procedures
      suggested for biobank research among all those guidelines, emanating from many
      different moral and legal traditions. A central question is whether this
      constitutes a threat to making progress in international biobank research, as
      some have argued. In this book, Chapter 1 suggests that there are sufficient and 
      well-established instruments and ethical principles available to guide research
      in this area. Basically I argue that there is no need for a top-down
      superstructure of detailed rules and guidelines to be imposed on biobank
      researchers. With the existing ethical review boards (ERBs) playing a central
      role guided by well-established ethical guidelines (e.g., the Helsinki
      Declaration) and solutions to specific ethical problems suggested in the
      literature, self-regulation by researchers providing arguments for balancing of
      interests in association with different research initiatives and protocols will
      be sufficient. Traditional information and consent procedures suffice and data
      protection implies a sovereign right of the individual citizen to grant the use
      of biobank material and personal data that is needed for biobank research.
      Clearly, there may still be inconsistencies in terminology when researchers of
      different nationalities meet in common enterprises, but both they and the ERBs
      are well equipped to sort out what is actually meant and propose different
      instruments for, for example, coding following recently established
      nomenclatures. The existing ERBs should play the key role, guided by the sound
      argumentation of the researchers in their applications to the board.
FAU - Hansson, Mats G
AU  - Hansson MG
AD  - Department of Public Health and Caring Sciences, Centre for Research Ethics &
      Bioethics, Uppsala University, Uppsala, Sweden. mats.hansson@crb.uu.se
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
SB  - IM
MH  - Biological Specimen Banks/*ethics/*legislation & jurisprudence
MH  - Humans
MH  - Informed Consent
EDAT- 2010/10/16 06:00
MHDA- 2011/02/01 06:00
CRDT- 2010/10/16 06:00
PHST- 2010/10/16 06:00 [entrez]
PHST- 2010/10/16 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
AID - 10.1007/978-1-59745-423-0_2 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2011;675:39-59. doi: 10.1007/978-1-59745-423-0_2.


PMID- 20949382
OWN - NLM
STAT- MEDLINE
DCOM- 20110128
LR  - 20101015
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Linking)
VI  - 675
DP  - 2011
TI  - Genetic research and biobanks.
PG  - 1-37
LID - 10.1007/978-1-59745-423-0_1 [doi]
AB  - Human biobanks, and genetic research databases, as referred to by the
      Organisation for Economic Co-operation and Development (OECD), are essential
      tools for modern biomedical research. Biobanks may consist in collections created
      in clinical diagnosis (such as pathology tissue samples in hospitals) or
      collections created for large-scale longitudinal research (such as the UK
      Biobank). Human tissue collections are regulated by a patchwork of national laws.
      However, there is an increasing international uniformity in national privacy laws
      based on 1980s OECD standards. There are similar uniform standards developing in 
      national research ethics guidelines. As biobanks develop collaborations and
      linkages, international harmonisation of legislation and human research
      regulation will be required across jurisdictions. It is essential that
      international public trust is maintained in biobanking research.
FAU - Chalmers, Don
AU  - Chalmers D
AD  - Faculty of Law, University of Tasmania, Hobart, TAS, Australia.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
SB  - IM
MH  - Biological Specimen Banks/*legislation & jurisprudence/trends
MH  - Databases, Genetic
MH  - *Genetic Research/legislation & jurisprudence
MH  - Humans
EDAT- 2010/10/16 06:00
MHDA- 2011/02/01 06:00
CRDT- 2010/10/16 06:00
PHST- 2010/10/16 06:00 [entrez]
PHST- 2010/10/16 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
AID - 10.1007/978-1-59745-423-0_1 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2011;675:1-37. doi: 10.1007/978-1-59745-423-0_1.


PMID- 20949321
OWN - NLM
STAT- MEDLINE
DCOM- 20110420
LR  - 20211020
IS  - 1572-8633 (Electronic)
IS  - 1386-7423 (Linking)
VI  - 14
IP  - 1
DP  - 2011 Feb
TI  - Bioethical concepts in theory and practice: an exploratory study of prenatal
      screening in Iceland.
PG  - 53-61
LID - 10.1007/s11019-010-9291-y [doi]
AB  - A hallmark of good antenatal care is to respect prospective parent's choices and 
      provide information in a way that encourages their autonomy and informed decision
      making. In this paper, we analyse the meaning of autonomous and informed decision
      making from the theoretical perspective and attempt to show how those concepts
      are described among prospective parents in early pregnancy and in the public
      media in a society where NT screening is almost a norm. We use interviews with
      Icelandic prospective parents in early pregnancy (N = 40) and material covering
      the discourse around prenatal screening in the media over 5 years period. Our
      analysis indicates that both prospective parents and the public media include
      ethical terms in their rhetoric around prenatal screening although those concepts
      differ in their expression. We conclude that the context in which these decisions
      are taken does not encourage moral reflection. Prospective parents describe that 
      there is a lack of dialogue with professionals when decisions are made about
      screening. With routine offer of screening the conceptualization of bioethical
      concepts finds its own way through a mainstream discourse which has limited
      connections to the theoretical notions. This has been neglected in the
      implementation of screening, as limited effort has been subject to audit with
      reference to explore how the offer of screening and informed choice is
      experienced among prospective parents.
FAU - Gottfreethsdottir, Helga
AU  - Gottfreethsdottir H
AD  - Department of Midwifery, Faculty of Nursing, University of Iceland, Eiriksgata
      34, IS-101, Reykjavik, Iceland. helgagot@hi.is
FAU - Arnason, Vilhjalmur
AU  - Arnason V
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Med Health Care Philos
JT  - Medicine, health care, and philosophy
JID - 9815900
SB  - IM
MH  - Bioethical Issues
MH  - Choice Behavior/ethics
MH  - Female
MH  - Genetic Testing/*ethics
MH  - Guidelines as Topic
MH  - Health Policy
MH  - Humans
MH  - Iceland
MH  - Informed Consent/ethics
MH  - Parents/*psychology
MH  - Pregnancy
MH  - Prenatal Diagnosis/*ethics
EDAT- 2010/10/16 06:00
MHDA- 2011/04/22 06:00
CRDT- 2010/10/16 06:00
PHST- 2010/10/16 06:00 [entrez]
PHST- 2010/10/16 06:00 [pubmed]
PHST- 2011/04/22 06:00 [medline]
AID - 10.1007/s11019-010-9291-y [doi]
PST - ppublish
SO  - Med Health Care Philos. 2011 Feb;14(1):53-61. doi: 10.1007/s11019-010-9291-y.


PMID- 20946106
OWN - NLM
STAT- MEDLINE
DCOM- 20110610
LR  - 20220408
IS  - 1095-8355 (Electronic)
IS  - 1065-6995 (Linking)
VI  - 35
IP  - 3
DP  - 2011 Mar
TI  - Generation of mesenchymal stem cell from human umbilical cord tissue using a
      combination enzymatic and mechanical disassociation method.
PG  - 221-6
LID - 10.1042/CBI20100326 [doi]
AB  - MSCs (mesenchymal stem cells) promise a great potential for regenerative medicine
      due to their unique properties of self-renewal, high plasticity, modulation of
      immune response and the flexibility for genetic modification. Therefore, the
      increasing demand for cellular therapy necessitates a larger-scale production of 
      MSC; however, the technical and ethical issues had put a halt on it. To date,
      studies have shown that MSC could be derived from human UC (umbilical cord),
      which is once considered as clinical waste. We have compared the two conventional
      methods which are classic enzymatic digestion and explant method with our newly
      tailored enzymatic-mechanical disassociation method to generate UC-MSC. The
      generated UC-MSCs from the methods above were characterized based on their
      immunophenotyping, early embryonic transcription factors expression and
      mesodermal differentiation ability. Our results show that enzymatic-mechanical
      disassociation method increase the initial nucleated cell yield greatly
      (approximately 160-fold) and maximized the successful rate of UC-MSC generation. 
      Enzymatic-mechanical disassociation-derived UC-MSC exhibited fibroblastic
      morphology and surface markers expression of CD105, CD73, CD29, CD90 and MHC
      class I. Furthermore, these cells constitutively express early embryonic
      transcription factors (Nanog, Oct-4, Sox-2 and Rex-1), as confirmed by RT-PCR,
      indicating their multipotency and high self-renewal capacity. They are also
      capable of differentiating into osteoblasts and adipocytes when given an
      appropriate induction. The present study demonstrates a new and efficient
      approach in generating MSC from UC, hence serving as ideal alternative source of 
      mesenchymal stem cell for clinical and research use.
FAU - Tong, Chih Kong
AU  - Tong CK
AD  - Department of Pathology, Faculty of Medicine and Health Sciences, Universiti
      Putra Malaysia, UPM Serdang, Selangor, Malaysia.
FAU - Vellasamy, Shalini
AU  - Vellasamy S
FAU - Tan, Boon Chong
AU  - Tan BC
FAU - Abdullah, Maha
AU  - Abdullah M
FAU - Vidyadaran, Sharmili
AU  - Vidyadaran S
FAU - Seow, Heng Fong
AU  - Seow HF
FAU - Ramasamy, Rajesh
AU  - Ramasamy R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Cell Biol Int
JT  - Cell biology international
JID - 9307129
RN  - 0 (Antigens, CD)
RN  - 0 (ENG protein, human)
RN  - 0 (Endoglin)
RN  - 0 (GPI-Linked Proteins)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Integrin beta1)
RN  - 0 (Kruppel-Like Transcription Factors)
RN  - 0 (NANOG protein, human)
RN  - 0 (Nanog Homeobox Protein)
RN  - 0 (Octamer Transcription Factor-3)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (SOXB1 Transcription Factors)
RN  - 0 (Thy-1 Antigens)
RN  - 0 (ZFP42 protein, human)
RN  - EC 3.1.3.5 (5'-Nucleotidase)
RN  - EC 3.1.3.5 (NT5E protein, human)
SB  - IM
MH  - 5'-Nucleotidase/metabolism
MH  - Antigens, CD/metabolism
MH  - Cell Differentiation
MH  - Cell Separation/methods
MH  - Endoglin
MH  - GPI-Linked Proteins/metabolism
MH  - Homeodomain Proteins/genetics/metabolism
MH  - Humans
MH  - Immunophenotyping
MH  - Integrin beta1/metabolism
MH  - Kruppel-Like Transcription Factors/genetics/metabolism
MH  - Mesenchymal Stem Cells/cytology/*metabolism
MH  - Nanog Homeobox Protein
MH  - Octamer Transcription Factor-3/genetics/metabolism
MH  - Receptors, Cell Surface/metabolism
MH  - SOXB1 Transcription Factors/genetics/metabolism
MH  - Thy-1 Antigens/metabolism
MH  - Umbilical Cord/*cytology
EDAT- 2010/10/16 06:00
MHDA- 2011/06/11 06:00
CRDT- 2010/10/16 06:00
PHST- 2010/10/16 06:00 [entrez]
PHST- 2010/10/16 06:00 [pubmed]
PHST- 2011/06/11 06:00 [medline]
AID - CBI20100326 [pii]
AID - 10.1042/CBI20100326 [doi]
PST - ppublish
SO  - Cell Biol Int. 2011 Mar;35(3):221-6. doi: 10.1042/CBI20100326.


PMID- 20938352
OWN - NLM
STAT- MEDLINE
DCOM- 20111129
LR  - 20151119
IS  - 1533-4112 (Electronic)
IS  - 1095-0680 (Linking)
VI  - 27
IP  - 2
DP  - 2011 Jun
TI  - Cognitive, mood, and electroencephalographic effects of noninvasive cortical
      stimulation with weak electrical currents.
PG  - 134-40
LID - 10.1097/YCT.0b013e3181e631a8 [doi]
AB  - OBJECTIVES: : The use of noninvasive cortical electrical stimulation with weak
      currents has significantly increased in basic and clinical human studies.
      Initial, preliminary studies with this technique have shown encouraging results; 
      however, the safety and tolerability of this method of brain stimulation have not
      been sufficiently explored yet. The purpose of our study was to assess the
      effects of direct current (DC) and alternating current (AC) stimulation at
      different intensities in order to measure their effects on cognition, mood, and
      electroencephalogram. METHODS: : Eighty-two healthy, right-handed subjects
      received active and sham stimulation in a randomized order. We conducted 164
      ninety-minute sessions of electrical stimulation in 4 different protocols to
      assess safety of (1) anodal DC of the dorsolateral prefrontal cortex (DLPFC); (2)
      cathodal DC of the DLPFC; (3) intermittent anodal DC of the DLPFC and; (4) AC on 
      the zygomatic process. We used weak currents of 1 to 2 mA (for DC experiments) or
      0.1 to 0.2 mA (for AC experiment). RESULTS: : We found no significant changes in 
      electroencephalogram, cognition, mood, and pain between groups and a low
      prevalence of mild adverse effects (0.11% and 0.08% in the active and sham
      stimulation groups, respectively), mainly, sleepiness and mild headache that were
      equally distributed between groups. CONCLUSIONS: : Here, we show no
      neurophysiological or behavioral signs that transcranial DC stimulation or AC
      stimulation with weak currents induce deleterious changes when comparing active
      and sham groups. This study provides therefore additional information for
      researchers and ethics committees, adding important results to the safety pool of
      studies assessing the effects of cortical stimulation using weak electrical
      currents. Further studies in patients with neuropsychiatric disorders are
      warranted.
FAU - Tadini, Laura
AU  - Tadini L
AD  - Laboratory of Neuromodulation, Spaulding Rehabilitation Hospital, Harvard Medical
      School, Boston, MA, USA.
FAU - El-Nazer, Rasheda
AU  - El-Nazer R
FAU - Brunoni, Andre Russowsky
AU  - Brunoni AR
FAU - Williams, Julie
AU  - Williams J
FAU - Carvas, Marcelo
AU  - Carvas M
FAU - Boggio, Paulo
AU  - Boggio P
FAU - Priori, Alberto
AU  - Priori A
FAU - Pascual-Leone, Alvaro
AU  - Pascual-Leone A
FAU - Fregni, Felipe
AU  - Fregni F
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J ECT
JT  - The journal of ECT
JID - 9808943
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Affect
MH  - Anxiety/etiology
MH  - *Cerebral Cortex
MH  - *Cognition
MH  - Electric Stimulation Therapy/*adverse effects/standards
MH  - *Electroencephalography
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pain/etiology
MH  - Safety
MH  - Surveys and Questionnaires
EDAT- 2010/10/13 06:00
MHDA- 2011/12/13 00:00
CRDT- 2010/10/13 06:00
PHST- 2010/10/13 06:00 [entrez]
PHST- 2010/10/13 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1097/YCT.0b013e3181e631a8 [doi]
PST - ppublish
SO  - J ECT. 2011 Jun;27(2):134-40. doi: 10.1097/YCT.0b013e3181e631a8.


PMID- 20927597
OWN - NLM
STAT- MEDLINE
DCOM- 20110420
LR  - 20211020
IS  - 1572-8633 (Electronic)
IS  - 1386-7423 (Linking)
VI  - 14
IP  - 1
DP  - 2011 Feb
TI  - Anti-theory in action? Planning for pandemics, triage and ICU or: how not to bite
      a bullet.
PG  - 91-100
LID - 10.1007/s11019-010-9289-5 [doi]
AB  - Anti-theory is a multi-faceted critique of moral theory which, it appears, is
      undergoing something of reassessment. In a recent paper Hamalainen discusses the 
      relevance of an anti-theoretical perspective for the activity of applied ethics. 
      This paper explores her view of anti-theory. In particular I examine its
      relevance for understanding the formal guidance on pandemic flu planning issues
      by the Department of Health (DoH) in the UK and some subsequent discussions
      around triage and reverse triage decisions which may be considered by both
      Primary and Secondary Care Trusts (PCTs and SCTs) (On the division between
      Primary and Secondary Care Trusts in the UK National Health Service see:
      http://www.nhs.uk/NHSEngland/thenhs/about/Pages/nhsstructure.aspx [Accessed
      August 2010]). in setting their own policies and which may face clinicians in the
      eventuality of a pandemic. Following Hamalainen in contrasting reflective
      equilibrium with her anti-theory inspired suggestion of an instrumental approach 
      to moral theory in practice I demonstrate how this understanding complements the 
      diversity of our intuitive moral judgements. Consequentially I suggest that this 
      anti-theoretical instrumental approach is in greater accord with the conditions
      under which such policy planning and decision making is, or will be, made.
      Furthermore, on the grounds of keeping open the ethical dimensions of medical
      practice in conditions of uncertainty, i.e. during a pandemic, I suggest that the
      anti-theoretical instrumental perspective is, ethically, the preferable approach 
      to producing such policies and guidelines.
FAU - Emmerich, Nathan
AU  - Emmerich N
AD  - School of Sociology, Social Policy and Social Work, Queen's University Belfast,
      Belfast, Northern Ireland, UK. nathan.emmerich@gmail.com
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Med Health Care Philos
JT  - Medicine, health care, and philosophy
JID - 9815900
SB  - IM
CIN - Psychother Psychosom. 2020;89(4):263-264. PMID: 32252058
MH  - Health Care Rationing/ethics
MH  - Health Planning/*ethics
MH  - Humans
MH  - Influenza A Virus, H1N1 Subtype/isolation & purification
MH  - Influenza, Human/*epidemiology/virology
MH  - Intensive Care Units
MH  - *Moral Obligations
MH  - Pandemics/*ethics
MH  - Surge Capacity
MH  - Triage/*ethics
MH  - United Kingdom/epidemiology
EDAT- 2010/10/12 06:00
MHDA- 2011/04/22 06:00
CRDT- 2010/10/08 06:00
PHST- 2010/10/08 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2011/04/22 06:00 [medline]
AID - 10.1007/s11019-010-9289-5 [doi]
PST - ppublish
SO  - Med Health Care Philos. 2011 Feb;14(1):91-100. doi: 10.1007/s11019-010-9289-5.


PMID- 20926987
OWN - NLM
STAT- MEDLINE
DCOM- 20110425
LR  - 20110118
IS  - 1540-0514 (Electronic)
IS  - 1073-2322 (Linking)
VI  - 35
IP  - 2
DP  - 2011 Feb
TI  - Challenges to effective research in acute trauma resuscitation: consent and
      endpoints.
PG  - 107-13
LID - 10.1097/SHK.0b013e3181f7fd01 [doi]
AB  - Selection of study endpoints is one of the most important decisions in the design
      of effective clinical trials. Late mortality (e.g., 28 days) is an unambiguous
      endpoint, accepted by regulatory agencies, but it is viewed as problematic among 
      researchers in the study of resuscitation for acute trauma injury with
      hemorrhagic shock. In February 2008, physicians, ethicists, statisticians, and
      research scientists from the military, academia, industry, the Federal Drug
      Administration, and the National Heart Lung and Blood Institute gathered to
      discuss the obstacles confronting the trauma community in their efforts to
      improve patient outcomes. The primary meeting objective was to generate
      preliminary suggestions for a series of follow-up meetings that will develop
      consensus guidelines for the design of large multicenter clinical trials. Twenty 
      short presentations and discussions, summarized here, outlined the group's
      concerns and suggestions. Successful and failed, completed or ongoing, clinical
      studies provided insight as to endpoints that may be of value for future trauma
      and shock studies. In addition to the importance of appropriate endpoints in
      study design, other related topics were discussed, including trauma epidemiology,
      patient enrollment and inclusion criteria, community consultation and the
      difficulty of obtaining informed consent in acute trauma research, and the
      inclusion of quality of life in composite endpoints. The consensus was that more 
      discussion was needed and that consideration of new endpoints for clinical trials
      in emergency trauma research was a worthwhile and necessary goal.
FAU - Holcomb, John B
AU  - Holcomb JB
AD  - Center for Translational Injury Research, University of Texas Health Science
      Center at Houston, 6410 Fannin St., Houston, TX, USA. John.Holcomb@uth.tmc.edu
FAU - Weiskopf, Richard
AU  - Weiskopf R
FAU - Champion, Howard
AU  - Champion H
FAU - Gould, Steven A
AU  - Gould SA
FAU - Sauer, R Michelle
AU  - Sauer RM
FAU - Brasel, Karen
AU  - Brasel K
FAU - Bochicchio, Grant
AU  - Bochicchio G
FAU - Bulger, Eileen
AU  - Bulger E
FAU - Cotton, Bryan A
AU  - Cotton BA
FAU - Davis, Daniel
AU  - Davis D
FAU - Dutton, Richard
AU  - Dutton R
FAU - Hauser, Carl J
AU  - Hauser CJ
FAU - Hess, John R
AU  - Hess JR
FAU - Hides, George A
AU  - Hides GA
FAU - Knudson, Paula
AU  - Knudson P
FAU - MacKenzie, Ellen
AU  - MacKenzie E
FAU - McGinnis, Robert L
AU  - McGinnis RL
FAU - Michalek, Joel
AU  - Michalek J
FAU - Moore, Frederick A
AU  - Moore FA
FAU - Omert, Laurel
AU  - Omert L
FAU - Pollock, Brad H
AU  - Pollock BH
FAU - Tortella, Bartholomew
AU  - Tortella B
FAU - Sugarman, Jeremy
AU  - Sugarman J
FAU - Schreiber, Martin A
AU  - Schreiber MA
FAU - Wade, Charles E
AU  - Wade CE
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Shock
JT  - Shock (Augusta, Ga.)
JID - 9421564
SB  - IM
MH  - Acute Disease
MH  - Animals
MH  - Congresses as Topic
MH  - Humans
MH  - Multicenter Studies as Topic
MH  - National Heart, Lung, and Blood Institute (U.S.)
MH  - Practice Guidelines as Topic
MH  - *Resuscitation
MH  - Shock, Hemorrhagic/epidemiology/physiopathology/*therapy
MH  - United States
MH  - United States Food and Drug Administration
MH  - Wounds and Injuries/epidemiology/physiopathology/*therapy
EDAT- 2010/10/12 06:00
MHDA- 2011/04/26 06:00
CRDT- 2010/10/08 06:00
PHST- 2010/10/08 06:00 [entrez]
PHST- 2010/10/12 06:00 [pubmed]
PHST- 2011/04/26 06:00 [medline]
AID - 10.1097/SHK.0b013e3181f7fd01 [doi]
PST - ppublish
SO  - Shock. 2011 Feb;35(2):107-13. doi: 10.1097/SHK.0b013e3181f7fd01.


PMID- 20924823
OWN - NLM
STAT- MEDLINE
DCOM- 20110429
LR  - 20151119
IS  - 1364-6915 (Electronic)
IS  - 1360-7863 (Linking)
VI  - 15
IP  - 1
DP  - 2011 Jan
TI  - Who should make the decision on the use of GPS for people with dementia?
PG  - 78-84
LID - 10.1080/13607861003713166 [doi]
AB  - OBJECTIVES: In recent years advanced technologies, such as Global Positioning
      Systems (GPS), allow for tracking of human spatial activity and provide the
      ability to intervene to manage that activity. The purpose of this study is to
      examine the issue of who should decide about the use of electronic tracking using
      GPS for people with dementia. METHODS: Based on quantitative data collected from 
      296 participants comprising cognitively intact elderly, family caregivers of
      people with dementia, social workers, other professionals, and social work
      students, study participants were asked to rate nine different potential
      decision-makers to make this decision. RESULTS: The results show that figures
      inside the family, particularly the spouse or the most involved family caregiver,
      were perceived more important in the decision-making process than figures outside
      the family, whereas the person with dementia was ranked third in the order of the
      figures. Since the decision to use GPS for tracking raises the ethical dilemma of
      personal safety versus autonomy and privacy of people with dementia, the findings
      seem to indicate that the reluctance of professional caregivers to assist family 
      caregivers to make this decision is experienced as frustrating. CONCLUSIONS: The 
      findings imply that in order to reach a balance between the wishes and interests 
      of both people with dementia and their family caregivers, there is a need for
      more active involvement of the professional caregivers to facilitate the family
      decision-making process.
FAU - Landau, Ruth
AU  - Landau R
AD  - The Hebrew University of Jerusalem, Mount Scopus, Israel. mslanda@mscc.huji.ac.il
FAU - Auslander, Gail K
AU  - Auslander GK
FAU - Werner, Shirli
AU  - Werner S
FAU - Shoval, Noam
AU  - Shoval N
FAU - Heinik, Jeremia
AU  - Heinik J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Aging Ment Health
JT  - Aging & mental health
JID - 9705773
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Decision Making
MH  - *Dementia
MH  - Female
MH  - *Geographic Information Systems
MH  - Humans
MH  - Israel
MH  - Male
MH  - Middle Aged
MH  - *Social Responsibility
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2010/10/07 06:00
MHDA- 2011/04/30 06:00
CRDT- 2010/10/07 06:00
PHST- 2010/10/07 06:00 [entrez]
PHST- 2010/10/07 06:00 [pubmed]
PHST- 2011/04/30 06:00 [medline]
AID - 927612720 [pii]
AID - 10.1080/13607861003713166 [doi]
PST - ppublish
SO  - Aging Ment Health. 2011 Jan;15(1):78-84. doi: 10.1080/13607861003713166.


PMID- 20885303
OWN - NLM
STAT- MEDLINE
DCOM- 20110609
LR  - 20151119
IS  - 1538-9804 (Electronic)
IS  - 0162-220X (Linking)
VI  - 34
IP  - 2
DP  - 2011 Mar-Apr
TI  - Which factors have the greatest influence on bereaved families' willingness to
      execute advance directives in Taiwan?
PG  - 98-106
LID - 10.1097/NCC.0b013e3181f22cac [doi]
AB  - BACKGROUND: Preferences for end-of-life care and attitudes toward executing
      advance directives (ADs) vary depending on ethical and cultural influences. In
      traditional Asian family-centered decision making, the family makes important
      medical decisions. Few studies have examined willingness of Taiwanese to execute 
      ADs. OBJECTIVE: This study aimed to investigate factors associated with
      willingness of bereaved families of cancer patients in Taiwan to execute ADs.
      METHODS: Participants were 280 individual family members of deceased cancer
      patients randomly selected from a cancer registry of an urban medical center in
      Taiwan. They completed self-reported questionnaires with information about their 
      knowledge of and attitudes toward ADs. RESULTS: Participants showed high
      willingness (86.4%) to complete ADs. Logistic regression analysis revealed 4
      important factors associated with their willingness: (1) participants were
      primary caregivers (odds ratio [OR], 2.64), (2) willingness to reelect to
      disclose terminal illness (OR, 4.39), (3) knowledge of the Hospice-Palliative
      Care Act (HPCA) (OR, 1.27), and (4) negative perceptions of the HPCA (ie, "cons")
      (OR, 1.07). Advanced analysis revealed that participants with more knowledge of
      the HPCA had fewer negative perceptions (beta = .60; P < .0001). CONCLUSION:
      Having more knowledge of hospice/palliative care and fewer negative perceptions
      of HPCA increases willingness to execute ADs for family members or self.
      IMPLICATIONS FOR PRACTICE: Active promotion of hospice/palliative care and public
      education about the HPCA provided by medical professionals would contribute to
      awareness of end-of-life care and knowledge of HPCA, thereby encouraging
      willingness to complete ADs.
FAU - Yang, Chia-Ling
AU  - Yang CL
AD  - School of Nursing, Mackay Medicine, Nursing and Management College, and
      Department of Nursing, College of Medicine, National Taiwan University, Taipei,
      Taiwan, Republic of China.
FAU - Chiu, Tai-Yuan
AU  - Chiu TY
FAU - Hsiung, Yi-Fang Yvonne
AU  - Hsiung YF
FAU - Hu, Wen-Yu
AU  - Hu WY
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer Nurs
JT  - Cancer nursing
JID - 7805358
SB  - IM
MH  - Adult
MH  - Advance Directives/legislation & jurisprudence/*psychology
MH  - Aged
MH  - Aged, 80 and over
MH  - *Attitude to Death
MH  - *Bereavement
MH  - Caregivers/*psychology
MH  - Cross-Sectional Studies
MH  - Culture
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - Hospice Care/legislation & jurisprudence/*psychology
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Palliative Care/legislation & jurisprudence/*psychology
MH  - Registries
MH  - Self Report
MH  - Surveys and Questionnaires
MH  - Taiwan
MH  - Young Adult
EDAT- 2010/10/05 06:00
MHDA- 2011/06/10 06:00
CRDT- 2010/10/02 06:00
PHST- 2010/10/02 06:00 [entrez]
PHST- 2010/10/05 06:00 [pubmed]
PHST- 2011/06/10 06:00 [medline]
AID - 10.1097/NCC.0b013e3181f22cac [doi]
PST - ppublish
SO  - Cancer Nurs. 2011 Mar-Apr;34(2):98-106. doi: 10.1097/NCC.0b013e3181f22cac.


PMID- 20874797
OWN - NLM
STAT- MEDLINE
DCOM- 20120119
LR  - 20220318
IS  - 1463-1318 (Electronic)
IS  - 1462-8910 (Linking)
VI  - 13
IP  - 10
DP  - 2011 Oct
TI  - Stenting large bowel obstruction avoids a stoma: consecutive series of 100
      patients.
PG  - 1138-41
LID - 10.1111/j.1463-1318.2010.02432.x [doi]
AB  - AIM: Large bowel obstruction (LBO) is a surgical emergency that requires urgent
      operative intervention and often a stoma. The introduction of a self-expanding
      metallic stent provides an alternative for this group of patients. The aim of
      this study was to assess prospectively the results in the first 100 consecutive
      patients with LBO undergoing attempted self-expanding metallic stent insertion at
      the Royal Prince Alfred Hospital, Sydney, Australia. METHOD: A prospective
      consecutive uncontrolled trial of 100 patients having an attempted self-expanding
      metallic stent insertion for LBO was performed after institutional ethical
      approval. RESULTS: The mean age was 63.9 years (range 16-95). Primary colorectal 
      cancer was the most common cause of LBO (61%). A self-expanding metallic stent
      was inserted with a palliative intent in 89% of patients. An initial technical
      success rate of 87% was achieved. Overall 30-day mortality was 7% (95% CI,
      3.4-13.7%), with only one stent-related death within 30 days of stent insertion. 
      Morbidity occurred in 20% of patients. Surgery was avoided in 69 patients and
      permanent stoma was avoided in 72 patients. The median follow up was 34.5 months 
      (range 1-64 months). CONCLUSION: In this uncontrolled study, self-expanding
      metallic stents had a low morbidity and a low procedure-related mortality. A
      randomized controlled trial has commenced in our institution, in which length of 
      stay, quality of life, morbidity and mortality of patients with stents are
      compared with those of patients having open procedures during palliative care for
      LBO.
CI  - (c) 2011 The Authors. Colorectal Disease (c) 2011 The Association of
      Coloproctology of Great Britain and Ireland.
FAU - Young, C J
AU  - Young CJ
AD  - Department of Colorectal Surgery, Royal Prince Alfred Hospital, New South Wales, 
      Australia. cyoungnsw@aol.com
FAU - Suen, M K L
AU  - Suen MK
FAU - Young, J
AU  - Young J
FAU - Solomon, M J
AU  - Solomon MJ
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - England
TA  - Colorectal Dis
JT  - Colorectal disease : the official journal of the Association of Coloproctology of
      Great Britain and Ireland
JID - 100883611
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Colonic Diseases/etiology/*surgery
MH  - Colorectal Neoplasms/*complications
MH  - Colostomy
MH  - Emergencies
MH  - Female
MH  - Humans
MH  - Intestinal Obstruction/etiology/*surgery
MH  - Male
MH  - Middle Aged
MH  - *Palliative Care
MH  - Rectal Diseases/etiology/*surgery
MH  - *Stents/adverse effects
MH  - Young Adult
EDAT- 2010/09/30 06:00
MHDA- 2012/01/20 06:00
CRDT- 2010/09/30 06:00
PHST- 2010/09/30 06:00 [entrez]
PHST- 2010/09/30 06:00 [pubmed]
PHST- 2012/01/20 06:00 [medline]
AID - 10.1111/j.1463-1318.2010.02432.x [doi]
PST - ppublish
SO  - Colorectal Dis. 2011 Oct;13(10):1138-41. doi: 10.1111/j.1463-1318.2010.02432.x.


PMID- 20853152
OWN - NLM
STAT- MEDLINE
DCOM- 20110420
LR  - 20220817
IS  - 1572-8633 (Electronic)
IS  - 1386-7423 (Linking)
VI  - 14
IP  - 1
DP  - 2011 Feb
TI  - The ethics of implementing human papillomavirus vaccination in developed
      countries.
PG  - 19-27
LID - 10.1007/s11019-010-9285-9 [doi]
AB  - Human papillomavirus (HPV) infection is the world's most common sexually
      transmitted infection. It is a prerequisite for cervical cancer, the second most 
      common cause of death in cancer among women worldwide, and is also believed to
      cause other anogenital and head and neck cancers. Vaccines that protect against
      the most common cancer-causing HPV types have recently become available, and
      different countries have taken different approaches to implementing vaccination. 
      This paper examines the ethics of alternative HPV vaccination strategies. It
      devotes particular attention to the major arguments for and against one strategy:
      voluntary, publicly funded vaccination for all adolescent boys and girls. This
      approach seems attractive because it would protect more people against cervical
      cancer and other HPV-related cancers than less inclusive alternatives, without
      the sacrifice of autonomy that a comparably broad compulsory programme would
      require. Also, the herd immunity that it would likely generate would protect
      those who remain unvaccinated, a major advantage from a justice perspective.
      However, there is a possibility that a HPV vaccination programme targeting all
      adolescents of both sexes is not considered sufficiently cost-effective. Also, it
      might pose more difficulties for achieving informed consent than comparable
      vaccination programmes against other diseases. Ultimately, society's choice of
      HPV vaccination strategy requires careful consideration not only of the values at
      stake but also of available and emerging scientific evidence.
FAU - Malmqvist, Erik
AU  - Malmqvist E
AD  - Centre for Research on Meaning, Ethics and Society, Universite Paris Descartes,
      45, rue des Sts. Peres, 75270, Paris Cedex 06, France.
      erik.malmqvist@parisdescartes.fr
FAU - Helgesson, Gert
AU  - Helgesson G
FAU - Lehtinen, Johannes
AU  - Lehtinen J
FAU - Natunen, Kari
AU  - Natunen K
FAU - Lehtinen, Matti
AU  - Lehtinen M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Med Health Care Philos
JT  - Medicine, health care, and philosophy
JID - 9815900
RN  - 0 (Papillomavirus Vaccines)
SB  - IM
MH  - Adolescent
MH  - Cross-Cultural Comparison
MH  - Developed Countries
MH  - Female
MH  - Humans
MH  - Immunity, Herd/drug effects
MH  - Immunization Programs/*ethics/organization & administration
MH  - Male
MH  - Papillomavirus Infections/*prevention & control
MH  - Papillomavirus Vaccines/*administration & dosage
MH  - Social Justice
MH  - Uterine Cervical Neoplasms/etiology/*prevention & control/virology
EDAT- 2010/09/21 06:00
MHDA- 2011/04/22 06:00
CRDT- 2010/09/21 06:00
PHST- 2010/09/21 06:00 [entrez]
PHST- 2010/09/21 06:00 [pubmed]
PHST- 2011/04/22 06:00 [medline]
AID - 10.1007/s11019-010-9285-9 [doi]
PST - ppublish
SO  - Med Health Care Philos. 2011 Feb;14(1):19-27. doi: 10.1007/s11019-010-9285-9.


PMID- 20835927
OWN - NLM
STAT- MEDLINE
DCOM- 20110623
LR  - 20211020
IS  - 1543-0154 (Electronic)
IS  - 0885-8195 (Linking)
VI  - 26
IP  - 1
DP  - 2011 Mar
TI  - Ethics consultation on a gynecologic oncology service: an opportunity for
      physician education.
PG  - 183-7
LID - 10.1007/s13187-010-0154-2 [doi]
AB  - The purpose of this study is to understand the features of gynecologic oncology
      patients who receive ethics consults in order to identify areas for physician
      education and improve patient care. A review of ethics consults for gynecologic
      oncology patients from 1993 to 2008 was performed. Information on all gynecologic
      oncology patients treated during the study interval was also collected to define 
      a base population for comparison. Forty-one consults were performed. Compared to 
      the base population, a greater proportion of consult patients had
      pregnancy-related malignancies (7.9% vs. 0.8%, p < 0.0001) and were African
      American (33.3% vs. 10.9%, p < 0.0001). The most common clinical case types
      involved identifying levels of appropriate treatment. Support of the health care 
      team and complex family dynamics were key underlying issues. Ethics consultation 
      provides a substantial resource in identifying relevant issues experienced by
      gynecologic oncology patients upon which physician educational initiatives may be
      based.
FAU - Schlumbrecht, Matthew P
AU  - Schlumbrecht MP
AD  - Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer
      Center, PO Box 301439, Unit 1362, 1515 Holcombe Boulevard, Houston, TX 77030,
      USA.
FAU - Gallagher, Colleen M
AU  - Gallagher CM
FAU - Sun, Charlotte C
AU  - Sun CC
FAU - Ramondetta, Lois M
AU  - Ramondetta LM
FAU - Bodurka, Diane C
AU  - Bodurka DC
LA  - eng
GR  - P30 CA016672/CA/NCI NIH HHS/United States
GR  - T32 CA101642/CA/NCI NIH HHS/United States
GR  - T32CA101642/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - J Cancer Educ
JT  - Journal of cancer education : the official journal of the American Association
      for Cancer Education
JID - 8610343
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Clinical Competence
MH  - Delivery of Health Care
MH  - *Education, Medical, Continuing
MH  - Ethics Consultation/*standards
MH  - Female
MH  - Genital Neoplasms, Female/*therapy
MH  - Humans
MH  - Medical Oncology/*education
MH  - Middle Aged
MH  - Physicians
MH  - Pregnancy
MH  - Pregnancy Complications
MH  - Young Adult
PMC - PMC5095615
MID - NIHMS823934
COIS- The authors declare that they have no conflict of interest.
EDAT- 2010/09/14 06:00
MHDA- 2011/06/24 06:00
CRDT- 2010/09/14 06:00
PHST- 2010/09/14 06:00 [entrez]
PHST- 2010/09/14 06:00 [pubmed]
PHST- 2011/06/24 06:00 [medline]
AID - 10.1007/s13187-010-0154-2 [doi]
PST - ppublish
SO  - J Cancer Educ. 2011 Mar;26(1):183-7. doi: 10.1007/s13187-010-0154-2.


PMID- 20817332
OWN - NLM
STAT- MEDLINE
DCOM- 20110606
LR  - 20220311
IS  - 1532-2793 (Electronic)
IS  - 0260-6917 (Linking)
VI  - 31
IP  - 2
DP  - 2011 Feb
TI  - A comparison of competencies between problem-based learning and non-problem-based
      graduate nurses.
PG  - 129-34
LID - 10.1016/j.nedt.2010.05.003 [doi]
AB  - Competence is essential to ensuring safe, ethical and legal nursing practice.
      Various teaching strategies are used in nursing education in an effort to enhance
      graduate competence by bridging the gap between theory learned in the classroom
      and professional practice as a nurse. The objective of this comparative
      descriptive research was to determine if there was a difference in self reported 
      competence between graduates from PBL and non PBL (NPBL) nursing programs. A
      convenience sample of 121 graduate nurses in one Canadian province, who had been 
      practicing for at least 6 months took part in the study. The researcher designed 
      questionnaire included both forced choice and open ended questions. There was no 
      statistical significance difference between the PBL and NPBL graduates on self
      reported entry-to-practice competence. However, several significant themes did
      emerge from the answers to open ended questions which asked graduates how their
      nursing programs prepared them to meet the entry-to-practice competencies and
      what program improvements they might suggest. Unlike the NPBL graduates, the PBL 
      graduates identified the structure and process of their programs as instrumental 
      in their preparation to meet the entry-to-practice competencies. PBL graduates
      associated their abilities to think critically and engage in self-directed
      evidence-based practice as key to enabling them to meet the competencies. A
      common theme for program improvement for both PBL and NPBL graduates was a
      request for more clinical time.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Applin, Harrison
AU  - Applin H
AD  - Critical Care Nursing, Royal Alexandra Hospital, Edmonton, Canada.
      happlin@telus.net
FAU - Williams, Beverly
AU  - Williams B
FAU - Day, Rene
AU  - Day R
FAU - Buro, Karen
AU  - Buro K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Scotland
TA  - Nurse Educ Today
JT  - Nurse education today
JID - 8511379
MH  - Adult
MH  - Canada
MH  - Clinical Competence/standards/*statistics & numerical data
MH  - Data Collection
MH  - Education, Medical, Graduate/*methods/standards/statistics & numerical data
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nursing Evaluation Research
MH  - Perception
MH  - Problem-Based Learning/*methods/standards/statistics & numerical data
MH  - Statistics as Topic
MH  - Surveys and Questionnaires
MH  - Teaching
MH  - Young Adult
EDAT- 2010/09/08 06:00
MHDA- 2011/06/07 06:00
CRDT- 2010/09/07 06:00
PHST- 2009/06/09 00:00 [received]
PHST- 2010/04/09 00:00 [revised]
PHST- 2010/05/09 00:00 [accepted]
PHST- 2010/09/07 06:00 [entrez]
PHST- 2010/09/08 06:00 [pubmed]
PHST- 2011/06/07 06:00 [medline]
AID - S0260-6917(10)00091-2 [pii]
AID - 10.1016/j.nedt.2010.05.003 [doi]
PST - ppublish
SO  - Nurse Educ Today. 2011 Feb;31(2):129-34. doi: 10.1016/j.nedt.2010.05.003.


PMID- 20809196
OWN - NLM
STAT- MEDLINE
DCOM- 20110420
LR  - 20211020
IS  - 1572-8633 (Electronic)
IS  - 1386-7423 (Linking)
VI  - 14
IP  - 1
DP  - 2011 Feb
TI  - Living in the hands of God. English Sunni e-fatwas on (non-)voluntary euthanasia 
      and assisted suicide.
PG  - 29-41
LID - 10.1007/s11019-010-9280-1 [doi]
AB  - Ever since the start of the twentieth century, a growing interest and importance 
      of studying fatwas can be noted, with a focus on Arabic printed fatwas (Wokoeck
      2009). The scholarly study of end-of-life ethics in these fatwas is a very recent
      feature, taking a first start in the 1980s (Anees 1984; Rispler-Chaim 1993).
      Since the past two decades, we have witnessed the emergence of a multitude of
      English fatwas that can easily be consulted through the Internet ('e-fatwas'),
      providing Muslims worldwide with a form of Islamic normative guidance on a huge
      variety of topics. Although English online fatwas do provide guidance for Muslims
      and Muslim minorities worldwide on a myriad of topics including end-of-life
      issues, they have hardly been studied. This study analyses Islamic views on
      (non-)voluntary euthanasia and assisted suicide as expressed in English Sunni
      fatwas published on independent--i.e. not created by established
      organisations--Islamic websites. We use Tyan's definition of a fatwa to
      distinguish between fatwas and other types of texts offering Islamic guidance
      through the Internet. The study of e-fatwas is framed in the context of Bunt's
      typology of Cyber Islamic Environments (Bunt 2009) and in the framework of Roy's 
      view on the virtual umma (Roy 2002). '(Non-)voluntary euthanasia and assisted
      suicide' are defined using Broeckaert's conceptual framework on treatment
      decisions at the end of life (Broeckaert 2008). We analysed 32 English Sunni
      e-fatwas. All of the e-fatwas discussed here firmly speak out against every form 
      of active termination of life. They often bear the same structure, basing
      themselves solely on Quranic verses and prophetic traditions, leaving aside
      classical jurisprudential discussions on the subject. In this respect they share 
      the characteristics central in Roy's typology of the fatwa in the virtual umma.
      On the level of content, they are in line with the international literature on
      Islamic end-of-life ethics. English Sunni e-fatwas make up an influential and
      therefore important developing body of Islamic orthodox normative authority on
      end-of-life ethics that is still open for further research.
FAU - Van den Branden, Stef
AU  - Van den Branden S
AD  - Faculty of Theology, Interdisciplinary Centre for the Study of Religion and World
      Views, K.U. Leuven, St.-Michielsstraat 4, bus 3101, Leuven, Belgium.
      stef.vandenbranden@theo.kuleuven.be
FAU - Broeckaert, Bert
AU  - Broeckaert B
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Med Health Care Philos
JT  - Medicine, health care, and philosophy
JID - 9815900
SB  - IM
MH  - Attitude to Death/*ethnology
MH  - Euthanasia/*ethics/trends
MH  - Humans
MH  - *Islam
MH  - *Religion and Medicine
MH  - Suicide, Assisted/*ethics
EDAT- 2010/09/03 06:00
MHDA- 2011/04/22 06:00
CRDT- 2010/09/03 06:00
PHST- 2010/09/03 06:00 [entrez]
PHST- 2010/09/03 06:00 [pubmed]
PHST- 2011/04/22 06:00 [medline]
AID - 10.1007/s11019-010-9280-1 [doi]
PST - ppublish
SO  - Med Health Care Philos. 2011 Feb;14(1):29-41. doi: 10.1007/s11019-010-9280-1.


PMID- 20803257
OWN - NLM
STAT- MEDLINE
DCOM- 20110825
LR  - 20211020
IS  - 1572-8633 (Electronic)
IS  - 1386-7423 (Linking)
VI  - 14
IP  - 2
DP  - 2011 May
TI  - Professional values in community and public health pharmacy.
PG  - 187-94
LID - 10.1007/s11019-010-9281-0 [doi]
AB  - General practice (community) pharmacy as a healthcare profession is largely
      devoted to therapeutic treatment of individual patients whether in dispensing
      medically authorised prescriptions or by providing members of the public with
      over-the-counter advice and service for a variety of common ailments. Recently,
      community pharmacy has been identified as an untapped resource available to
      undertake important aspects of public health and in particular health promotion. 
      In contrast to therapeutic treatment, public health primarily concerns the health
      of the entire population, rather than the health of individuals (Childress et al.
      in J Law Med Ethics 30:170-178, 2002). Thus, an important question for the
      profession is whether those moral and professional values that are appropriate to
      the therapeutic care of individual patients are relevant and adequate to support 
      the additional public health role.
FAU - Badcott, David
AU  - Badcott D
AD  - Centre for Applied Ethics, Cardiff University, Humanities Building, Colum Drive, 
      Cardiff CF10 3EU, UK. badcottd@cf.ac.uk
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Med Health Care Philos
JT  - Medicine, health care, and philosophy
JID - 9815900
SB  - IM
MH  - Community Pharmacy Services/*ethics/trends
MH  - Ethics, Professional
MH  - Humans
MH  - Medication Therapy Management/*ethics/trends
MH  - Pharmacists/*ethics
MH  - Public Health/*ethics
MH  - United Kingdom
EDAT- 2010/08/31 06:00
MHDA- 2011/08/27 06:00
CRDT- 2010/08/31 06:00
PHST- 2010/08/31 06:00 [entrez]
PHST- 2010/08/31 06:00 [pubmed]
PHST- 2011/08/27 06:00 [medline]
AID - 10.1007/s11019-010-9281-0 [doi]
PST - ppublish
SO  - Med Health Care Philos. 2011 May;14(2):187-94. doi: 10.1007/s11019-010-9281-0.


PMID- 20676775
OWN - NLM
STAT- MEDLINE
DCOM- 20110420
LR  - 20211020
IS  - 1572-8633 (Electronic)
IS  - 1386-7423 (Linking)
VI  - 14
IP  - 1
DP  - 2011 Feb
TI  - Can curative or life-sustaining treatment be withheld or withdrawn? The opinions 
      and views of Indian palliative-care nurses and physicians.
PG  - 5-18
LID - 10.1007/s11019-010-9273-0 [doi]
AB  - INTRODUCTION: Decisions to withdraw or withhold curative or life-sustaining
      treatment can have a huge impact on the symptoms which the palliative-care team
      has to control. Palliative-care patients and their relatives may also turn to
      palliative-care physicians and nurses for advice regarding these treatments. We
      wanted to assess Indian palliative-care nurses and physicians' attitudes towards 
      withholding and withdrawal of curative or life-sustaining treatment. METHOD: From
      May to September 2008, we interviewed 14 physicians and 13 nurses working in
      different palliative-care programmes in New Delhi, using a semi-structured
      questionnaire. For the interviews and analysis of the data we followed
      Grounded-Theory methodology. RESULTS: Withholding a curative or life-sustaining
      treatment which may prolong a terminal cancer patient's life with a few weeks but
      also has severe side-effects was generally considered acceptable by the
      interviewees. The majority of the interviewees agreed that life-sustaining
      treatments can be withdrawn in a patient who is in an irreversible coma. The
      palliative-care physicians and nurses were of the opinion that a patient has the 
      right to refuse life-saving curative treatment. While reflecting upon the ethical
      acceptability of withholding or withdrawal of curative or life-sustaining
      treatment, the physicians and nurses were concerned about the whole patient and
      other people who may be affected by the decision. They were convinced they can
      play an important advisory role in the decision-making process. CONCLUSION: While
      deciding about the ethical issues, the physicians and nurses do not restrict
      their considerations to the physical aspects of the disease, but also reflect
      upon the complex wider consequences of the treatment decisions.
FAU - Gielen, Joris
AU  - Gielen J
AD  - Interdisciplinary Centre for the Study of Religion and World View (Catholic
      University Leuven), Sint-Michielsstraat 4-Bus 3101, 3000, Leuven, Belgium.
      Joris.Gielen@theo.kuleuven.be
FAU - Bhatnagar, Sushma
AU  - Bhatnagar S
FAU - Mishra, Seema
AU  - Mishra S
FAU - Chaturvedi, Arvind K
AU  - Chaturvedi AK
FAU - Gupta, Harmala
AU  - Gupta H
FAU - Rajvanshi, Ambika
AU  - Rajvanshi A
FAU - Van den Branden, Stef
AU  - Van den Branden S
FAU - Broeckaert, Bert
AU  - Broeckaert B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Med Health Care Philos
JT  - Medicine, health care, and philosophy
JID - 9815900
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Attitude to Death
MH  - Ethics, Nursing
MH  - Female
MH  - Humans
MH  - India
MH  - Life Support Care/*ethics
MH  - Male
MH  - Palliative Care/*ethics
MH  - Physicians/*ethics
MH  - *Treatment Refusal
MH  - Withholding Treatment/*ethics
EDAT- 2010/08/03 06:00
MHDA- 2011/04/22 06:00
CRDT- 2010/08/03 06:00
PHST- 2010/08/03 06:00 [entrez]
PHST- 2010/08/03 06:00 [pubmed]
PHST- 2011/04/22 06:00 [medline]
AID - 10.1007/s11019-010-9273-0 [doi]
PST - ppublish
SO  - Med Health Care Philos. 2011 Feb;14(1):5-18. doi: 10.1007/s11019-010-9273-0.


PMID- 20676724
OWN - NLM
STAT- MEDLINE
DCOM- 20110722
LR  - 20211020
IS  - 1618-727X (Electronic)
IS  - 0897-1889 (Linking)
VI  - 24
IP  - 2
DP  - 2011 Apr
TI  - The role of key image notes in CT imaging study interpretation.
PG  - 366-72
LID - 10.1007/s10278-010-9317-2 [doi]
AB  - The objective of the study was to investigate the clinical effects of CT key
      image notes (KIN) in the interpretation of a CT image study. All experiments were
      approved by the ethics committee of the local district. Six experienced
      radiologists were equally divided into routine reporting (RR) group and KIN
      reporting (KIN) group. CT scans of each 100 consecutive cases before and after
      using KIN technique were randomly selected, and the reports were made by group RR
      and KIN, respectively. All the reports were again reviewed 3 months later by both
      groups. All the results with using or not using KIN were interpreted and
      reinterpreted after 3 months by six clinicians, who were experienced in picture
      archiving and communication system (PACS) applications and were equally divided
      into the clinical routine report group and the clinical KIN report group,
      respectively. The results were statistically analyzed; the time used in making a 
      report, the re-reading time 3 months later, and the consistency of imaging
      interpretation were determined and compared between groups. After using KIN
      technique, the time used in making a report was significantly increased (8.77 +/-
      5.27 vs. 10.53 +/- 5.71 min, P < 0.05), the re-reading time was decreased (5.23
      +/- 2.54 vs. 4.99 +/- 1.70 min, P < 0.05), the clinical interpretation and
      reinterpretation time after 3 months were decreased, and the consistency of the
      interpretation, reinterpretation between different doctors in different time was 
      markedly improved (P < 0.01). CT report with KIN technique in PACS can
      significantly improve the consistency of the interpretation and efficiency in
      routine clinical work.
FAU - Fan, Shu-Feng
AU  - Fan SF
AD  - Radiology Department, Taizhou Hospital affiliated to Wenzhou Medical College,
      #150 Ximen Road, Linhai, 210009, Zhejiang Province, 317000, China.
      shufengfan@163.com
FAU - Xu, Zhe
AU  - Xu Z
FAU - He, Hai-Qing
AU  - He HQ
FAU - Ding, Jian-Rong
AU  - Ding JR
FAU - Teng, Gao-Jun
AU  - Teng GJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Digit Imaging
JT  - Journal of digital imaging
JID - 9100529
SB  - IM
MH  - Humans
MH  - Image Interpretation, Computer-Assisted/*methods
MH  - Observer Variation
MH  - *Radiology Information Systems
MH  - Tomography, X-Ray Computed/*methods
PMC - PMC3056968
EDAT- 2010/08/03 06:00
MHDA- 2011/07/23 06:00
CRDT- 2010/08/03 06:00
PHST- 2010/08/03 06:00 [entrez]
PHST- 2010/08/03 06:00 [pubmed]
PHST- 2011/07/23 06:00 [medline]
AID - 10.1007/s10278-010-9317-2 [doi]
PST - ppublish
SO  - J Digit Imaging. 2011 Apr;24(2):366-72. doi: 10.1007/s10278-010-9317-2.


PMID- 20667030
OWN - NLM
STAT- MEDLINE
DCOM- 20110901
LR  - 20160511
IS  - 1442-200X (Electronic)
IS  - 1328-8067 (Linking)
VI  - 53
IP  - 2
DP  - 2011 Apr
TI  - R1 version, self-concept in Taiwanese adolescents with congenital heart disease.
PG  - 168-74
LID - 10.1111/j.1442-200X.2010.03207.x [doi]
AB  - BACKGROUND: The objectives of this study were to evaluate and compare differences
      in self-concept between male and female adolescents with congenital heart
      disease, and to compare the self-concepts of these adolescents to that of the
      general adolescent population using normative data. METHODS: A total of 300
      adolescents, 143 male and 157 female, from two medical centers in Taiwan
      completed the Tennessee Self-Concept Scales and the scores of male and female
      subjects were compared. The scores of adolescents with congenital heart disease
      were also compared with normative data of healthy Taiwanese adolescents. RESULTS:
      Girls with congenital heart disease showed significantly lower mean scores in
      Physical Self, Social Self, Personal Self, Academic Self and Overall Self domains
      on the Tennessee Self-Concept Scales when compared to boys with congenital heart 
      disease. When compared to the average value of normative data, adolescent boys
      with congenital heart disease had significantly higher mean T-scores on Physical 
      Self, Family Self, Social Self, Personal Self, Academic Self and Overall Self,
      and adolescent girls had significantly higher mean T-scores in Moral-ethical
      Self, Social Self, Personal Self, Academic Self and Overall Self domains. There
      were weak negative correlations between severity of congenital heart disease and 
      Physical Self T-scores, and between the number of heart operations and Academic
      T-scores. CONCLUSIONS: Self-concept in adolescents with congenital heart disease 
      is similar to or even higher than that of their normal counterparts. More
      holistic views of adolescents with congenital heart disease, including their
      self-concept, appear warranted, especially for adolescent girls with congenital
      heart disease.
CI  - (c) 2011 The Authors.Pediatrics International (c) 2011 Japan Pediatric Society.
FAU - Chen, Chi-Wen
AU  - Chen CW
AD  - Department of Nursing, College of Medicine, Fu-Jen Catholic University, Taipei
      Hsien. 039761@mail.fju.edu.tw
FAU - Chen, Yueh-Chih
AU  - Chen YC
FAU - Beckstead, Jason W
AU  - Beckstead JW
FAU - Kennel, Susan
AU  - Kennel S
FAU - Evans, Mary E
AU  - Evans ME
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Pediatr Int
JT  - Pediatrics international : official journal of the Japan Pediatric Society
JID - 100886002
SB  - IM
MH  - Adolescent
MH  - Female
MH  - Heart Defects, Congenital/*psychology
MH  - Humans
MH  - Male
MH  - *Self Concept
MH  - Taiwan
EDAT- 2010/07/30 06:00
MHDA- 2011/09/02 06:00
CRDT- 2010/07/30 06:00
PHST- 2010/07/30 06:00 [entrez]
PHST- 2010/07/30 06:00 [pubmed]
PHST- 2011/09/02 06:00 [medline]
AID - PED3207 [pii]
AID - 10.1111/j.1442-200X.2010.03207.x [doi]
PST - ppublish
SO  - Pediatr Int. 2011 Apr;53(2):168-74. doi: 10.1111/j.1442-200X.2010.03207.x.


PMID- 20652417
OWN - NLM
STAT- MEDLINE
DCOM- 20110825
LR  - 20211020
IS  - 1572-8633 (Electronic)
IS  - 1386-7423 (Linking)
VI  - 14
IP  - 2
DP  - 2011 May
TI  - Evidence, ethics and inclusion: a broader base for NICE.
PG  - 111-21
LID - 10.1007/s11019-010-9256-1 [doi]
AB  - The National Institute for Health and Clinical Excellence (hereafter NICE) was
      created in 1998 to give guidance on which treatments should be provided by the
      British National Health Service, and to whom. So it has a crucial role as an
      agent of distributive justice. In this paper I argue that it is failing to
      adequately explain and justify its decisions in the public arena, particularly in
      terms of distributive justice; and that this weakens its legitimacy, to the
      detriment of the National Health Service as a whole. I argue that this failure
      arises from the fact that NICE works within the frameworks of positivist science 
      and liberal ethics, largely to the exclusion of other perspectives. This
      narrowness of view prevents NICE from properly connecting with the range of moral
      concerns represented in the population. I argue for NICE's deliberations to
      become more inclusive, both in terms of epistemology, and also in terms of
      ethical perspectives. And I suggest a range of perspectives that could usefully
      be included. Finally I offer a framework of structures, philosophies and
      discussion process that will enable competing perspectives to be debated fairly
      and productively in this process.
FAU - Wilmot, Stephen
AU  - Wilmot S
AD  - University of British Columbia, 407-2263 Redbud Lane, Vancouver, BC V6K 4V7,
      Canada. Stephen.Wilmot@nursing.ubc.ca
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Med Health Care Philos
JT  - Medicine, health care, and philosophy
JID - 9815900
SB  - IM
MH  - *Ethics, Clinical
MH  - *Evidence-Based Medicine
MH  - Financing, Government/ethics/standards
MH  - Government Regulation
MH  - Humans
MH  - Quality-Adjusted Life Years
MH  - Social Justice/*ethics/standards
MH  - State Medicine/economics/*ethics/standards
MH  - United Kingdom
EDAT- 2010/07/24 06:00
MHDA- 2011/08/27 06:00
CRDT- 2010/07/24 06:00
PHST- 2010/07/24 06:00 [entrez]
PHST- 2010/07/24 06:00 [pubmed]
PHST- 2011/08/27 06:00 [medline]
AID - 10.1007/s11019-010-9256-1 [doi]
PST - ppublish
SO  - Med Health Care Philos. 2011 May;14(2):111-21. doi: 10.1007/s11019-010-9256-1.


PMID- 20652416
OWN - NLM
STAT- MEDLINE
DCOM- 20110825
LR  - 20211020
IS  - 1572-8633 (Electronic)
IS  - 1386-7423 (Linking)
VI  - 14
IP  - 2
DP  - 2011 May
TI  - Avoiding bias in medical ethical decision-making. Lessons to be learnt from
      psychology research.
PG  - 155-62
LID - 10.1007/s11019-010-9263-2 [doi]
AB  - When ethical decisions have to be taken in critical, complex medical situations, 
      they often involve decisions that set the course for or against life-sustaining
      treatments. Therefore the decisions have far-reaching consequences for the
      patients, their relatives, and often for the clinical staff. Although the rich
      psychology literature provides evidence that reasoning may be affected by
      undesired influences that may undermine the quality of the decision outcome, not 
      much attention has been given to this phenomenon in health care or ethics
      consultation. In this paper, we aim to contribute to the sensitization of the
      problem of systematic reasoning biases by showing how exemplary individual and
      group biases can affect the quality of decision-making on an individual and group
      level. We are addressing clinical ethicists as well as clinicians who guide
      complex decision-making processes of ethical significance. Knowledge regarding
      exemplary group psychological biases (e.g. conformity bias), and individual
      biases (e.g. stereotypes), will be taken from the disciplines of social
      psychology and cognitive decision science and considered in the field of ethical 
      decision-making. Finally we discuss the influence of intuitive versus analytical 
      (systematical) reasoning on the validity of ethical decision-making.
FAU - Albisser Schleger, Heidi
AU  - Albisser Schleger H
AD  - Department for Medical and Health Ethics, Medical Faculty, University Hospital
      Basel, Basel, Switzerland. heidi.albisser@unibas.ch
FAU - Oehninger, Nicole R
AU  - Oehninger NR
FAU - Reiter-Theil, Stella
AU  - Reiter-Theil S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Med Health Care Philos
JT  - Medicine, health care, and philosophy
JID - 9815900
SB  - IM
MH  - Decision Making/*ethics
MH  - *Ethics, Clinical
MH  - Humans
MH  - *Prejudice
MH  - Stereotyping
EDAT- 2010/07/24 06:00
MHDA- 2011/08/27 06:00
CRDT- 2010/07/24 06:00
PHST- 2010/07/24 06:00 [entrez]
PHST- 2010/07/24 06:00 [pubmed]
PHST- 2011/08/27 06:00 [medline]
AID - 10.1007/s11019-010-9263-2 [doi]
PST - ppublish
SO  - Med Health Care Philos. 2011 May;14(2):155-62. doi: 10.1007/s11019-010-9263-2.


PMID- 20640516
OWN - NLM
STAT- MEDLINE
DCOM- 20110825
LR  - 20211020
IS  - 1572-8633 (Electronic)
IS  - 1386-7423 (Linking)
VI  - 14
IP  - 2
DP  - 2011 May
TI  - Care and competence in medical practice: Francis Peabody confronts Jason Posner.
PG  - 143-53
LID - 10.1007/s11019-010-9257-0 [doi]
AB  - In this paper, I discuss the role of care and competence, as well as their
      relationship to one another, in contemporary medical practice. I distinguish
      between two types of care. The first type, care(1), represents a natural concern 
      that motivates physicians to help or to act on the behalf of patients, i.e. to
      care about them. However, this care cannot guarantee the correct technical or
      right ethical action of physicians to meet the bodily and existential needs of
      patients, i.e. to take care of them-care(2). To that end, physicians must be
      competent in the practice of medicine both as evidence-based science (technical
      competence) and as patient-centered art (ethical competence). Only then, I argue,
      can physicians take care of (care(2)) patients' bodily and existential needs in a
      compassionate and comprehensive manner. Importantly, although care(1) precedes
      competence, competence--both technical and ethical--is required for genuine
      care(2), which in turn reinforces an authentic care(1). I utilize the play Wit,
      especially the character Jason Posner, and Francis Peabody's exposition on caring
      for patients, to illustrate the role of care and competence in contemporary
      medical practice.
FAU - Marcum, James A
AU  - Marcum JA
AD  - Department of Philosophy, Baylor University, One Bear Place #97273, Waco, TX
      76798, USA. James_Marcum@baylor.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Med Health Care Philos
JT  - Medicine, health care, and philosophy
JID - 9815900
SB  - IM
MH  - *Clinical Competence
MH  - Clinical Trials as Topic
MH  - *Empathy
MH  - Female
MH  - Humans
MH  - Narration
MH  - Ovarian Neoplasms/diagnosis/drug therapy/psychology
MH  - *Physician-Patient Relations
EDAT- 2010/07/20 06:00
MHDA- 2011/08/27 06:00
CRDT- 2010/07/20 06:00
PHST- 2010/07/20 06:00 [entrez]
PHST- 2010/07/20 06:00 [pubmed]
PHST- 2011/08/27 06:00 [medline]
AID - 10.1007/s11019-010-9257-0 [doi]
PST - ppublish
SO  - Med Health Care Philos. 2011 May;14(2):143-53. doi: 10.1007/s11019-010-9257-0.


PMID- 20626425
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20191210
IS  - 1399-0012 (Electronic)
IS  - 0902-0063 (Linking)
VI  - 25
IP  - 1
DP  - 2011 Jan-Feb
TI  - The outcome of commercial kidney transplant tourism in Pakistan.
PG  - 171-3
LID - 10.1111/j.1399-0012.2010.01299.x [doi]
AB  - The lack of cadaver organs for transplantation motivates some Balkan patients to 
      go to developing countries to buy a kidney. We have followed 36 patients who
      received kidney transplants in Lahore and Rawalpindi, Pakistan. The patients had 
      not been cleared for transplantation with a standard pre-transplant work-up: 80% 
      were hepatitis-C virus (HCV) or HBsAg positive. During follow-up, seven patients 
      died. Sixteen patients experienced wound infections with post-operative hernias, 
      and three patients developed peri-renal hematomas. Six abscesses and four
      lymphoceles occurred, and four urinary fistulas were surgically treated.
      Nephrectomy was performed in three patients because of renal artery thrombosis.
      Nine patients developed active hepatitis C, and four patients manifested
      cytomegalovirus disease. Three patients developed steroid diabetes, and three
      patients experienced acute myocardial infarction. Nine patients had one or more
      rejection episodes. Urinary tract infection with Pseudomonas or Escherichia
      occurred frequently. The one-yr patient and graft survival rates were 80% and
      68%, respectively. Paid unregulated renal transplantation is not recommended for 
      both ethical reasons and because of an association with excessive morbidity and
      mortality.
CI  - (c) 2010 John Wiley & Sons A/S.
FAU - Ivanovski, Ninoslav
AU  - Ivanovski N
AD  - University Clinic of Nephrology, Medical Faculty, University Ss Cyril and
      Methodius, Skopje, Macedonia. nivanovski@yahoo.com
FAU - Masin, Jelka
AU  - Masin J
FAU - Rambabova-Busljetic, Irena
AU  - Rambabova-Busljetic I
FAU - Pusevski, Vlado
AU  - Pusevski V
FAU - Dohcev, Saso
AU  - Dohcev S
FAU - Ivanovski, Ognen
AU  - Ivanovski O
FAU - Popov, Zivko
AU  - Popov Z
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Clin Transplant
JT  - Clinical transplantation
JID - 8710240
SB  - IM
CIN - Clin Transplant. 2011 May-Jun;25(3):E223-4. PMID: 21395691
MH  - Adolescent
MH  - Adult
MH  - Developing Countries
MH  - Female
MH  - Follow-Up Studies
MH  - Graft Survival
MH  - Hepacivirus/isolation & purification
MH  - Hepatitis B/*complications/surgery
MH  - Hepatitis B virus/isolation & purification
MH  - Hepatitis C/*complications/surgery
MH  - Humans
MH  - Kidney Diseases/*surgery
MH  - Kidney Transplantation/*mortality
MH  - Male
MH  - *Medical Tourism
MH  - Middle Aged
MH  - *Outcome Assessment, Health Care
MH  - Pakistan
MH  - *Postoperative Complications
MH  - Survival Rate
MH  - Young Adult
EDAT- 2010/07/16 06:00
MHDA- 2011/06/03 06:00
CRDT- 2010/07/15 06:00
PHST- 2010/07/15 06:00 [entrez]
PHST- 2010/07/16 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
AID - CTR1299 [pii]
AID - 10.1111/j.1399-0012.2010.01299.x [doi]
PST - ppublish
SO  - Clin Transplant. 2011 Jan-Feb;25(1):171-3. doi: 10.1111/j.1399-0012.2010.01299.x.


PMID- 20625343
OWN - NLM
STAT- MEDLINE
DCOM- 20111005
LR  - 20191210
IS  - 1529-7535 (Print)
IS  - 1529-7535 (Linking)
VI  - 12
IP  - 2
DP  - 2011 Mar
TI  - Successful treatment with rituximab for acute refractory thrombotic
      thrombocytopenic purpura related to acquired ADAMTS13 deficiency: a pediatric
      report and literature review.
PG  - e90-3
LID - 10.1097/PCC.0b013e3181e89f8f [doi]
AB  - OBJECTIVE: To report the case of a child with severe autoimmune thrombotic
      thrombocytopenic purpura (TTP) resistant to plasma exchange and steroids who was 
      successfully treated with rituximab. DESIGN: Case report and review of the
      literature on pediatric acquired TTP. The report was approved by an independent
      local ethics committee. SETTING: Pediatric intensive care unit in a tertiary care
      children's hospital. PATIENT: A 10-yr-old boy was referred to the emergency unit 
      with fever, vomiting, confusion, hemolytic anemia, thrombocytopenia, and mild
      acute renal failure. An atypical hemolytic uremic syndrome was suspected, and
      plasma exchange was started urgently. The patient was refractory to plasma
      therapy and presented critical complications. After a diagnosis of acquired TTP
      attributable to anti-ADAMTS13 autoantibodies had been made, he was treated with
      rituximab, which resulted in a stable clinical remission. INTERVENTIONS:
      Rituximab therapy. MEASUREMENTS AND MAIN RESULTS: Clinical remission.
      CONCLUSIONS: TTP is a rare but life-threatening condition in children that is
      characterized by hemolytic anemia, thrombocytopenia, and signs of ischemic organ 
      dysfunction. If renal involvement is present, TTP may be misdiagnosed as
      hemolytic uremic syndrome, but reliable screening for ADAMTS13 activity and
      anti-ADAMTS autoantibodies allow us to distinguish the two entities and provide
      adequate therapy.
FAU - Harambat, Jerome
AU  - Harambat J
AD  - Service de Pediatrie Hopital Pellegrin-Enfants, CHU de Bordeaux and Universite de
      Bordeaux, Bordeaux, France. jerome.harambat@chu-bordeaux.fr
FAU - Lamireau, Delphine
AU  - Lamireau D
FAU - Delmas, Yahsou
AU  - Delmas Y
FAU - Ryman, Anne
AU  - Ryman A
FAU - Llanas, Brigitte
AU  - Llanas B
FAU - Brissaud, Olivier
AU  - Brissaud O
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Pediatr Crit Care Med
JT  - Pediatric critical care medicine : a journal of the Society of Critical Care
      Medicine and the World Federation of Pediatric Intensive and Critical Care
      Societies
JID - 100954653
RN  - 0 (Antibodies, Monoclonal, Murine-Derived)
RN  - 0 (Immunologic Factors)
RN  - 4F4X42SYQ6 (Rituximab)
RN  - EC 3.4.24.- (ADAM Proteins)
RN  - EC 3.4.24.87 (ADAMTS13 Protein)
RN  - EC 3.4.24.87 (ADAMTS13 protein, human)
SB  - IM
MH  - ADAM Proteins/*deficiency/immunology
MH  - ADAMTS13 Protein
MH  - Antibodies, Monoclonal, Murine-Derived/*therapeutic use
MH  - Child
MH  - Humans
MH  - Immunologic Factors/*therapeutic use
MH  - Intensive Care Units, Pediatric
MH  - Male
MH  - Outcome Assessment, Health Care
MH  - Purpura, Thrombotic Thrombocytopenic/*drug therapy/physiopathology
MH  - Rituximab
EDAT- 2010/07/14 06:00
MHDA- 2011/10/06 06:00
CRDT- 2010/07/14 06:00
PHST- 2010/07/14 06:00 [entrez]
PHST- 2010/07/14 06:00 [pubmed]
PHST- 2011/10/06 06:00 [medline]
AID - 10.1097/PCC.0b013e3181e89f8f [doi]
PST - ppublish
SO  - Pediatr Crit Care Med. 2011 Mar;12(2):e90-3. doi: 10.1097/PCC.0b013e3181e89f8f.


PMID- 20575149
OWN - NLM
STAT- MEDLINE
DCOM- 20110728
LR  - 20110401
IS  - 1099-1050 (Electronic)
IS  - 1057-9230 (Linking)
VI  - 20
IP  - 6
DP  - 2011 Jun
TI  - Saving lives versus life-years in rural Bangladesh: an ethical preferences
      approach.
PG  - 723-36
LID - 10.1002/hec.1627 [doi]
AB  - Using a random sample of individuals in rural Bangladesh, this paper investigates
      people's ethical preferences regarding relative values of lives when it comes to 
      saving lives of individuals of different ages. By assuming that an individual has
      preferences concerning different states of the world, and that these preferences 
      can be described by an individual social welfare function, the individuals'
      preferences for life-saving programs are elicited using a pair-wise choice
      experiment involving different life-saving programs. In the analyses, we
      calculate the social marginal rates of substitution between saved lives of people
      of different ages. We also test whether people have preferences for saving more
      life-years rather than only saving lives. In particular, we test and compare the 
      two hypotheses that only lives matter and that only life-years matter. The
      results indicate that the value of a saved life decreases rapidly with age and
      that people have strong preferences for saving life-years rather than lives per
      se. Overall, the results clearly show the importance of the number of life-years 
      saved in the valuation of life.
CI  - 2010 John Wiley & Sons, Ltd.
FAU - Johansson-Stenman, Olof
AU  - Johansson-Stenman O
AD  - Department of Economics, University of Gothenburg, Gothenburg, Sweden.
FAU - Mahmud, Minhaj
AU  - Mahmud M
FAU - Martinsson, Peter
AU  - Martinsson P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Health Econ
JT  - Health economics
JID - 9306780
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Bangladesh
MH  - Choice Behavior/*ethics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Models, Statistical
MH  - *Rural Population
MH  - Social Values
MH  - *Value of Life
MH  - Young Adult
EDAT- 2010/06/25 06:00
MHDA- 2011/07/29 06:00
CRDT- 2010/06/25 06:00
PHST- 2010/06/25 06:00 [entrez]
PHST- 2010/06/25 06:00 [pubmed]
PHST- 2011/07/29 06:00 [medline]
AID - 10.1002/hec.1627 [doi]
PST - ppublish
SO  - Health Econ. 2011 Jun;20(6):723-36. doi: 10.1002/hec.1627.


PMID- 20573037
OWN - NLM
STAT- MEDLINE
DCOM- 20110524
LR  - 20151119
IS  - 1399-3038 (Electronic)
IS  - 0905-6157 (Linking)
VI  - 22
IP  - 1 Pt 1
DP  - 2011 Feb
TI  - Infant feeding practices and physician diagnosed atopic dermatitis: a prospective
      cohort study in Taiwan.
PG  - 43-9
LID - 10.1111/j.1399-3038.2010.01007.x [doi]
AB  - It is common to recommend breastfeeding and a delayed introduction of solids to
      prevent atopic dermatitis (AD). However, the scientific evidence for this is
      inconclusive. The aim of this study was to explore the effect of breastfeeding
      and solids on AD, when taking account of reverse causality. This on-going birth
      cohort study was designed to sample 24,200 representative post-partum women and
      their babies from the Taiwan National Birth Registration database. Using two home
      interviews at 6 and 18 months after birth, with structured questionnaires about
      diet and physician's diagnosis of AD by parental reports, a total of 20,172 pairs
      (83.4%) were reviewed completely. Considering reverse causality, we excluded 2399
      children with AD in the first 6 months of life and 18,733 were finally recruited.
      All study participants provided informed consent as approved by the Ethics Review
      Board of the National Taiwan College of Public Health. After adjustment for
      potential confounders, the overall results showed that the increased duration of 
      breastfeeding seemed to increase the risk of AD at 18 months in children.
      However, no significant effect was found for the delayed introduction of solids
      on the risk of AD. There is no evidence of a protective effect of prolonged
      breastfeeding and a delayed introduction of solids against AD among children at
      age 18 months, and may even be a risk factor of AD.
CI  - (c) 2010 John Wiley & Sons A/S.
FAU - Chuang, Chao-Hua
AU  - Chuang CH
AD  - Department of Nursing, Chang Jung Christian University, 396 Sec.1 Chang Jung
      Road, Kway Jen, Tainan, Taiwan. chchuang@mail.cjcu.edu.tw
FAU - Hsieh, Wu-Shiun
AU  - Hsieh WS
FAU - Chen, Yi-Chun
AU  - Chen YC
FAU - Chang, Pei-Jen
AU  - Chang PJ
FAU - Hurng, Baai-Shyun
AU  - Hurng BS
FAU - Lin, Shio-Jean
AU  - Lin SJ
FAU - Chen, Pau-Chung
AU  - Chen PC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society
      of Pediatric Allergy and Immunology
JID - 9106718
SB  - IM
MH  - Adult
MH  - *Breast Feeding/adverse effects
MH  - Cohort Studies
MH  - Dermatitis, Atopic/*diagnosis/epidemiology/*etiology/prevention & control
MH  - *Feeding Methods
MH  - Female
MH  - Humans
MH  - Infant
MH  - *Infant Food/adverse effects
MH  - Interviews as Topic
MH  - Male
MH  - Odds Ratio
MH  - Parents
MH  - Physicians
MH  - Prospective Studies
MH  - Risk Factors
MH  - Surveys and Questionnaires
MH  - Taiwan
MH  - Time Factors
MH  - Young Adult
EDAT- 2010/06/25 06:00
MHDA- 2011/05/25 06:00
CRDT- 2010/06/25 06:00
PHST- 2010/06/25 06:00 [entrez]
PHST- 2010/06/25 06:00 [pubmed]
PHST- 2011/05/25 06:00 [medline]
AID - PAI1007 [pii]
AID - 10.1111/j.1399-3038.2010.01007.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2011 Feb;22(1 Pt 1):43-9. doi:
      10.1111/j.1399-3038.2010.01007.x.


PMID- 20562690
OWN - NLM
STAT- MEDLINE
DCOM- 20140605
LR  - 20130917
IS  - 1533-404X (Electronic)
IS  - 0195-7910 (Linking)
VI  - 32
IP  - 3
DP  - 2011 Sep
TI  - Autopsy: Traditional Jewish laws and customs "Halacha".
PG  - 300-3
LID - 10.1097/PAF.0b013e3181e79307 [doi]
AB  - Judaism has many traditions, customs, rules, and laws, which relate to the proper
      and ethical disposition of a decedent when a Medical Examiner/ Coroner is
      involved. In almost all United States jurisdictions, statutes mandate the need to
      determine the cause and manner of death (Coroners' Act PA Pl. 323, num. 130,
      section 1237). This article is a review of some religious writings, legal
      precedents, and forensic authorities, which may help to assist the Medical
      Examiner/Coroner when confronted with a Jewish decedent. There can be flexibility
      as to the extent that such forensic studies can and should be performed. The
      final consent and interpretation of the rules, laws, traditions, and customs will
      rest with the courts and local rabbinic authority.
FAU - Goodman, Norman R
AU  - Goodman NR
AD  - From the *Office of the Chester County Coroner, West Chester; daggerPhoenixville;
      and double daggerMontgomery County Coroner's Office, Norristown,PA.
FAU - Goodman, Jeffrey L
AU  - Goodman JL
FAU - Hofman, Walter I
AU  - Hofman WI
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Am J Forensic Med Pathol
JT  - The American journal of forensic medicine and pathology
JID - 8108948
SB  - IM
MH  - Autopsy/*methods
MH  - Coroners and Medical Examiners
MH  - Exhumation/legislation & jurisprudence
MH  - Forensic Medicine/*legislation & jurisprudence
MH  - Humans
MH  - Israel
MH  - *Jews
MH  - *Judaism
MH  - Magnetic Resonance Imaging
MH  - Religion and Medicine
MH  - Third-Party Consent/legislation & jurisprudence
MH  - Tomography, X-Ray
EDAT- 2010/06/22 06:00
MHDA- 2014/06/06 06:00
CRDT- 2010/06/22 06:00
PHST- 2010/06/22 06:00 [entrez]
PHST- 2010/06/22 06:00 [pubmed]
PHST- 2014/06/06 06:00 [medline]
AID - 10.1097/PAF.0b013e3181e79307 [doi]
PST - ppublish
SO  - Am J Forensic Med Pathol. 2011 Sep;32(3):300-3. doi:
      10.1097/PAF.0b013e3181e79307.


PMID- 20556519
OWN - NLM
STAT- MEDLINE
DCOM- 20110420
LR  - 20211020
IS  - 1572-8633 (Electronic)
IS  - 1386-7423 (Linking)
VI  - 14
IP  - 1
DP  - 2011 Feb
TI  - A Good Samaritan inspired foundation for a fair health care system.
PG  - 73-9
LID - 10.1007/s11019-010-9259-y [doi]
AB  - Distributive justice on the income and on the service aspects is the most vexing 
      modern day problem for the creation and maintenance of an all inclusive health
      care system. A pervasive problem of all current schemes is the lack of effective 
      cost control, which continues to result in increasing burdens for all public and 
      private stakeholders. This proposal posits that the responsibility and financial 
      obligation to achieve an ideal outcome of equal and affordable access and
      benefits for all citizens is misplaced. The Good Samaritan demonstrated basic
      ethical principles, which are revisited, elaborated and integrated into a new
      approach to health care. The participants are limited to individual contributors 
      and beneficiaries and organized as a citizen carried, closed, independent, and
      self-sufficient self-governing cooperative for their own and the benefit of a
      minority of disadvantaged health care consumers. The government assumes
      oversight, provides arbitration, enforces democratic decision making, a scheme of
      progressive taxation, a separate and transparent accounting system, and a balance
      between income and reinvestment in health care. The results are a fair
      distribution of cost, its effective control, and increased individual motivation 
      to take on responsibility for personal health as a private good and a sharpened
      focus towards community health. At the sociopolitical level the government as
      well as employers are released from the inappropriate burden of catering to
      individual health.
FAU - Frangenberg, Elmar H
AU  - Frangenberg EH
AD  - Department of Neurology, University of Rochester School of Medicine and
      Dentistry, Rochester, NY, USA. cfran@frontiernet.net
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Med Health Care Philos
JT  - Medicine, health care, and philosophy
JID - 9815900
SB  - IM
MH  - Delivery of Health Care/economics/*ethics
MH  - Health Expenditures
MH  - Health Policy/*economics
MH  - Humans
MH  - Patient Rights/*ethics
MH  - Social Justice/economics/*ethics
MH  - United States
PMC - PMC3015393
EDAT- 2010/06/18 06:00
MHDA- 2011/04/22 06:00
CRDT- 2010/06/18 06:00
PHST- 2010/06/18 06:00 [entrez]
PHST- 2010/06/18 06:00 [pubmed]
PHST- 2011/04/22 06:00 [medline]
AID - 10.1007/s11019-010-9259-y [doi]
PST - ppublish
SO  - Med Health Care Philos. 2011 Feb;14(1):73-9. doi: 10.1007/s11019-010-9259-y.


PMID- 20552281
OWN - NLM
STAT- MEDLINE
DCOM- 20110420
LR  - 20211020
IS  - 1572-8633 (Electronic)
IS  - 1386-7423 (Linking)
VI  - 14
IP  - 1
DP  - 2011 Feb
TI  - Effecting change through dialogue: Habermas' theory of communicative action as a 
      tool in medical lifestyle interventions.
PG  - 81-90
LID - 10.1007/s11019-010-9260-5 [doi]
AB  - Adjustments of everyday life in order to prevent disease or treat illness afflict
      partly unconscious preferences and cultural expectations that are often difficult
      to change. How should one, in medical contexts, talk with patients about everyday
      life in ways that might penetrate this blurred complexity, and help people find
      goals and make decisions that are both compatible with a good life and possible
      to accomplish? In this article we pursue the question by discussing how Habermas'
      theory of communicative action can be implemented in decision-making processes in
      general practice. The theory of deliberative decision-making offers practical
      guidelines for what to talk about and how to do it. For a decision to be rooted
      in patients' everyday life it has to take into consideration the patient's
      practical circumstances, emotions and preferences, and what he or she perceives
      as ethically right behaviour towards other people. The aim is a balanced
      conversation, demonstrating respect, consistency and sincerity, as well as
      offering information and clarifying reasons. Verbalising reasons for one's
      preferences may increase awareness of values and norms, which can then be
      reflected upon, producing decisions rooted in what the patient perceives as good 
      and right behaviour. The asymmetry of medical encounters is both a resource and a
      challenge, demanding patient-centred medical leadership, characterised by empathy
      and ability to take the patient's perspective. The implementation and adjustments
      of Habermas' theory in general practice is illustrated by a case story. Finally, 
      applications of the theory are discussed.
FAU - Walseth, Liv Tveit
AU  - Walseth LT
AD  - Research Unit for General Practice, Uni Health, Bergen, Norway. liv@walseth.no
FAU - Schei, Edvin
AU  - Schei E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Med Health Care Philos
JT  - Medicine, health care, and philosophy
JID - 9815900
SB  - IM
MH  - *Communication
MH  - Counseling/*methods
MH  - Decision Making
MH  - *Health Behavior
MH  - Health Promotion/methods
MH  - Humans
MH  - *Life Style
MH  - Patient-Centered Care
MH  - *Physician-Patient Relations
EDAT- 2010/06/17 06:00
MHDA- 2011/04/22 06:00
CRDT- 2010/06/17 06:00
PHST- 2010/06/17 06:00 [entrez]
PHST- 2010/06/17 06:00 [pubmed]
PHST- 2011/04/22 06:00 [medline]
AID - 10.1007/s11019-010-9260-5 [doi]
PST - ppublish
SO  - Med Health Care Philos. 2011 Feb;14(1):81-90. doi: 10.1007/s11019-010-9260-5.


PMID- 20550593
OWN - NLM
STAT- MEDLINE
DCOM- 20110609
LR  - 20211020
IS  - 1369-7625 (Electronic)
IS  - 1369-6513 (Linking)
VI  - 14
IP  - 1
DP  - 2011 Mar
TI  - Inside 'Inside View': reflections on stimulating debate and engagement through a 
      multimedia live theatre production on the dilemmas and issues of pre-natal
      screening policy and practice.
PG  - 1-9
LID - 10.1111/j.1369-7625.2010.00597.x [doi]
AB  - BACKGROUND: The role of applied theatre in engaging both lay and professional
      publics with debate on health policy and practice is an emergent field. This
      paper discusses the development, production performance and discussion of 'Inside
      View'. OBJECTIVES: The objectives were to produce applied theatre from research
      findings of a completed study on genetic prenatal screening, exploring the
      dilemmas for women and health professionals of prenatal genetic screening, and to
      engage audiences in debate and reflection on the dilemmas of prenatal genetic
      screening. METHODS: 'Inside View' was developed from a multidisciplinary research
      study through identification of emergent themes from qualitative interviews, and 
      development of these by the writer, theatre producer and media technologist with 
      input from the researchers. FINDINGS: Inside View was performed in London and the
      Midlands to varied audiences with a panel discussion and evaluation post
      performance. The audiences were engaged in debate that was relevant to them
      professionally and personally. Knowledge translation through applied theatre is
      an effective tool for engaging the public but the impact subsequently is unclear.
      There are ethical issues of unexpected disclosure during discussion post
      performance and the process of transforming research findings into applied
      theatre requires time and trust within the multidisciplinary team as well as
      adequate resourcing.
CI  - (c) 2010 The Authors. Health Expectations (c) 2010 Blackwell Publishing Ltd.
FAU - Hundt, Gillian Lewando
AU  - Hundt GL
AD  - Institute of Health, School of Health and Social Studies, University of Warwick, 
      Coventry, UK. gillian.hundt@warwick.ac.uk
FAU - Bryanston, Claudette
AU  - Bryanston C
FAU - Lowe, Pam
AU  - Lowe P
FAU - Cross, Saul
AU  - Cross S
FAU - Sandall, Jane
AU  - Sandall J
FAU - Spencer, Kevin
AU  - Spencer K
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Health Expect
JT  - Health expectations : an international journal of public participation in health 
      care and health policy
JID - 9815926
SB  - IM
MH  - *Art
MH  - Communication
MH  - Female
MH  - Health Education/*methods
MH  - Health Personnel/education
MH  - Humans
MH  - Midwifery/education
MH  - *Multimedia
MH  - Pregnancy
MH  - *Prenatal Care
MH  - *Prenatal Diagnosis
PMC - PMC5060556
EDAT- 2010/06/17 06:00
MHDA- 2011/06/10 06:00
CRDT- 2010/06/17 06:00
PHST- 2010/06/17 06:00 [entrez]
PHST- 2010/06/17 06:00 [pubmed]
PHST- 2011/06/10 06:00 [medline]
AID - HEX597 [pii]
AID - 10.1111/j.1369-7625.2010.00597.x [doi]
PST - ppublish
SO  - Health Expect. 2011 Mar;14(1):1-9. doi: 10.1111/j.1369-7625.2010.00597.x.


PMID- 20514512
OWN - NLM
STAT- MEDLINE
DCOM- 20110722
LR  - 20211020
IS  - 1573-3602 (Electronic)
IS  - 1050-5350 (Linking)
VI  - 27
IP  - 1
DP  - 2011 Mar
TI  - Reasons on the similarity of objections with regards to gambling and speculation 
      in Islamic finance and conventional finance.
PG  - 1-13
LID - 10.1007/s10899-010-9201-5 [doi]
AB  - Gambling and speculation which leads to zero-sum outcomes are prohibited in
      Islamic finance and condemned in conventional finance. This article explores the 
      reasons for the similarity of objections towards gambling and speculation. Three 
      probable reasons are explored namely the concept of stewardship in conventional
      thought and the concept of khalifa in Islam, Christianity and morality's
      influence on conventional law and finance and the concept of ethics of sacrifice 
      and ethics of tolerance.
FAU - Kunhibava, Sherin
AU  - Kunhibava S
AD  - International Shariah Research Academy (ISRA), 2nd Floor, Annexe Block, Menara
      Tun Razak, Jalan Raja Laut, Malaysia. sherin@isra.my
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Gambl Stud
JT  - Journal of gambling studies
JID - 9425991
SB  - IM
MH  - Christianity
MH  - Cultural Characteristics
MH  - Financial Management/*ethics
MH  - Gambling/*economics/*ethnology
MH  - Humans
MH  - *Islam
MH  - Life Style
MH  - *Religion and Psychology
MH  - *Religious Philosophies
MH  - *Social Values/ethnology
EDAT- 2010/06/02 06:00
MHDA- 2011/07/23 06:00
CRDT- 2010/06/02 06:00
PHST- 2010/06/02 06:00 [entrez]
PHST- 2010/06/02 06:00 [pubmed]
PHST- 2011/07/23 06:00 [medline]
AID - 10.1007/s10899-010-9201-5 [doi]
PST - ppublish
SO  - J Gambl Stud. 2011 Mar;27(1):1-13. doi: 10.1007/s10899-010-9201-5.


PMID- 20497170
OWN - NLM
STAT- MEDLINE
DCOM- 20110422
LR  - 20101223
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 25
IP  - 2
DP  - 2011 Feb
TI  - Literature, history and the humanization of bioethics.
PG  - 112-8
LID - 10.1111/j.1467-8519.2010.01818.x [doi]
AB  - This paper considers the disciplines of literature and history and the
      contributions each makes to the discourse of bioethics. In each case I note the
      pedagogic ends that can be enacted though the appropriate use of the each of
      these disciplines in the sphere of medical education, particularly in the medical
      ethics classroom.(1) I then explore the contribution that both these disciplines 
      and their respective methodologies can and do bring to the academic field of
      bioethics. I conclude with a brief consideration of the relations between
      literature and history with particular attention to the possibilities for a
      future bioethics informed by history and literature after the empirical turn.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Emmerich, Nathan
AU  - Emmerich N
AD  - School of Sociology, Social Policy and Social Work at Queen's University Belfast,
      The Institute ofGovernance, 63 University Road, Belfast BT7 1NN, United Kingdom. 
      nemmerich01@qub.ac.uk
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - *Bioethics/trends
MH  - *History
MH  - Humans
MH  - *Literature
EDAT- 2010/05/26 06:00
MHDA- 2011/04/26 06:00
CRDT- 2010/05/26 06:00
PHST- 2010/05/26 06:00 [entrez]
PHST- 2010/05/26 06:00 [pubmed]
PHST- 2011/04/26 06:00 [medline]
AID - BIOT1818 [pii]
AID - 10.1111/j.1467-8519.2010.01818.x [doi]
PST - ppublish
SO  - Bioethics. 2011 Feb;25(2):112-8. doi: 10.1111/j.1467-8519.2010.01818.x.


PMID- 20496048
OWN - NLM
STAT- MEDLINE
DCOM- 20110712
LR  - 20211020
IS  - 1573-6571 (Electronic)
IS  - 0022-4197 (Linking)
VI  - 50
IP  - 1
DP  - 2011 Mar
TI  - How Muslim and non-Muslim chaplains serve Muslim patients? Does the interfaith
      chaplaincy model have room for Muslims' experiences?
PG  - 46-61
LID - 10.1007/s10943-010-9357-4 [doi]
AB  - Chaplaincy is typically practiced within the contexts of the Jewish and Christian
      traditions, and little attention has been paid to the influence of the Islamic
      perspective of nursing and caring. Therefore, many Muslim patients might not
      receive appropriate care for their religious and spiritual needs, especially as
      they relate to daily religious practices and worship, medical ethics, and
      end-of-life treatment choices. This study examined Muslim and non-Muslim
      chaplains' approaches to pastoral care used with Muslim patients in New York City
      hospitals. The study used in-depth interviews with 33 Muslim and non-Muslim
      chaplains. The results indicate areas of both convergence and divergence.
FAU - Abu-Ras, Wahiba
AU  - Abu-Ras W
AD  - School of Social Work, Adelphi University, One South Avenue, Garden City, NY
      11530, USA. abu-ras@adelphi.edu
FAU - Laird, Lance
AU  - Laird L
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Relig Health
JT  - Journal of religion and health
JID - 2985199R
SB  - IM
MH  - *Clergy
MH  - Humans
MH  - Interviews as Topic
MH  - *Islam
MH  - New York City
MH  - *Patients
MH  - *Professional-Patient Relations
EDAT- 2010/05/25 06:00
MHDA- 2011/07/13 06:00
CRDT- 2010/05/25 06:00
PHST- 2010/05/25 06:00 [entrez]
PHST- 2010/05/25 06:00 [pubmed]
PHST- 2011/07/13 06:00 [medline]
AID - 10.1007/s10943-010-9357-4 [doi]
PST - ppublish
SO  - J Relig Health. 2011 Mar;50(1):46-61. doi: 10.1007/s10943-010-9357-4.


PMID- 20495875
OWN - NLM
STAT- MEDLINE
DCOM- 20110825
LR  - 20211020
IS  - 1572-8633 (Electronic)
IS  - 1386-7423 (Linking)
VI  - 14
IP  - 2
DP  - 2011 May
TI  - Confusions in the equipoise concept and the alternative of fully informed
      overlapping rational decisions.
PG  - 133-42
LID - 10.1007/s11019-010-9255-2 [doi]
AB  - Despite its several variations, the central position of equipoise is that
      subjects in clinical experiments should not be randomized to conditions when
      others believe that better alternatives exist. This position has been challenged 
      over issues of which group in the medical or research community is authorized to 
      make that determination, and it has been argued that informed consent provides
      sufficient ethical protection for participants independent of equipoise. In this 
      paper I frame ethical participation in clinical research as a two-party decision 
      process involving offering and accepting participation under informed consent.
      Nine conditions are identified in which it is possible that potential
      participants and researchers or care professionals can rationally choose
      divergent actions based on identical understandings of the situation. Under such 
      circumstances, researchers or care professionals cannot ethically substitute
      their understanding of equipoise in the situation for the patients' choices, or
      vice versa.
FAU - Chambers, David W
AU  - Chambers DW
AD  - Arthur A. Dugoni School of Dentistry, University of the Pacific, 2155 Webster
      Street, San Francisco, CA 94115, USA. dchambers@pacific.edu
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Med Health Care Philos
JT  - Medicine, health care, and philosophy
JID - 9815900
SB  - IM
MH  - Decision Making/ethics
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Randomized Controlled Trials as Topic/*ethics
MH  - *Therapeutic Equipoise
EDAT- 2010/05/25 06:00
MHDA- 2011/08/27 06:00
CRDT- 2010/05/25 06:00
PHST- 2010/05/25 06:00 [entrez]
PHST- 2010/05/25 06:00 [pubmed]
PHST- 2011/08/27 06:00 [medline]
AID - 10.1007/s11019-010-9255-2 [doi]
PST - ppublish
SO  - Med Health Care Philos. 2011 May;14(2):133-42. doi: 10.1007/s11019-010-9255-2.


PMID- 20495507
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20161125
IS  - 1529-7535 (Print)
IS  - 1529-7535 (Linking)
VI  - 12
IP  - 1
DP  - 2011 Jan
TI  - Changes in lung volume during spells in children with Tetralogy of Fallot under
      general anesthesia.
PG  - e40-2
LID - 10.1097/PCC.0b013e3181e2a2fb [doi]
AB  - OBJECTIVE: To describe the changes in end-expiratory lung volume and ventilation 
      inhomogeneities during spells in three children with Tetralogy of Fallot. DESIGN:
      After approval of the institutional Ethics Committee was obtained, children were 
      included in a study protocol that included the assessment of end-expiratory lung 
      volume and ventilation inhomogeneity, using a sulfur hexafluoride multibreath
      washout technique at different times before and during the surgical repair of
      congenital heart disease. Additional parental consent was sought to publish this 
      subseries. SETTING: Operation theater in a tertiary-care university hospital.
      PATIENTS: We report the changes in end-expiratory lung volume and ventilation
      inhomogeneity in three children undergoing Tetralogy of Fallot repair who spelled
      before surgical incision. While starting the immediate treatment with
      phenylephrine and increasing Fio2 to 1.0, we were able to measure respiratory
      function. During the spell, end-expiratory lung volume decreased and ventilation 
      inhomogeneities increased significantly and only recovered slowly even after
      return of Sao2 to prespell values. CONCLUSIONS: These data show the deleterious
      effect of a spell on respiratory function, which may worsen hypoxemia. The loss
      in lung volume can have a deleterious additive effect in the presence of a spell,
      particularly because of the slow improvement after treatment.
FAU - von Ungern-Sternberg, Britta S
AU  - von Ungern-Sternberg BS
AD  - Department of Anesthesia, Princess Margaret Hospital for Children, Perth,
      Australia. Britta.regli-vonungern@health.wa.gov.au
FAU - Habre, Walid
AU  - Habre W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pediatr Crit Care Med
JT  - Pediatric critical care medicine : a journal of the Society of Critical Care
      Medicine and the World Federation of Pediatric Intensive and Critical Care
      Societies
JID - 100954653
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - *Anesthesia, General
MH  - Child, Preschool
MH  - Humans
MH  - Hypoxia/physiopathology
MH  - Infant
MH  - Lung Volume Measurements
MH  - Male
MH  - Oxygen/metabolism
MH  - Prospective Studies
MH  - Tetralogy of Fallot/physiopathology/*surgery
EDAT- 2010/05/25 06:00
MHDA- 2011/06/03 06:00
CRDT- 2010/05/25 06:00
PHST- 2010/05/25 06:00 [entrez]
PHST- 2010/05/25 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
AID - 10.1097/PCC.0b013e3181e2a2fb [doi]
PST - ppublish
SO  - Pediatr Crit Care Med. 2011 Jan;12(1):e40-2. doi: 10.1097/PCC.0b013e3181e2a2fb.


PMID- 20491867
OWN - NLM
STAT- MEDLINE
DCOM- 20110531
LR  - 20121115
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 11
IP  - 1
DP  - 2011 Apr
TI  - A robust, particularist ethical assessment of medical tourism.
PG  - 16-29
LID - 10.1111/j.1471-8847.2010.00282.x [doi]
AB  - Recently, in increasing numbers, citizens of wealthy nations are heading to
      poorer countries for medical care. They are traveling to the global South as
      medical tourists because in their home nations either they cannot get timely
      medical care or they cannot afford needed treatments. This essay offers a robust,
      particularist ethical assessment of the practice of citizens of richer nations
      traveling to poorer countries for healthcare.
CI  - (c) 2010 Blackwell Publishing Ltd.
FAU - Meghani, Zahra
AU  - Meghani Z
AD  - University of Rhode Island - Philosophy, Kingston, RI 02881, USA.
      meghaniz@mail.uri.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
SB  - IM
MH  - Developed Countries
MH  - Developing Countries
MH  - Federal Government
MH  - *Health Care Costs/trends
MH  - Health Care Sector/*ethics/legislation & jurisprudence/trends
MH  - Health Services Accessibility/*ethics
MH  - Humans
MH  - India
MH  - *Insurance Coverage/economics
MH  - *Insurance, Health/economics
MH  - Medical Tourism/*ethics/*trends
MH  - *Politics
MH  - Population Dynamics
MH  - Poverty
MH  - United States
EDAT- 2010/05/25 06:00
MHDA- 2011/06/01 06:00
CRDT- 2010/05/25 06:00
PHST- 2010/05/25 06:00 [entrez]
PHST- 2010/05/25 06:00 [pubmed]
PHST- 2011/06/01 06:00 [medline]
AID - DEWB282 [pii]
AID - 10.1111/j.1471-8847.2010.00282.x [doi]
PST - ppublish
SO  - Dev World Bioeth. 2011 Apr;11(1):16-29. doi: 10.1111/j.1471-8847.2010.00282.x.


PMID- 20390453
OWN - NLM
STAT- MEDLINE
DCOM- 20111202
LR  - 20211020
IS  - 1573-3394 (Electronic)
IS  - 1065-3058 (Linking)
VI  - 19
IP  - 2
DP  - 2011 Jun
TI  - On the notion of (medical) invasiveness.
PG  - 99-106
LID - 10.1007/s10728-010-0149-5 [doi]
AB  - The relation between the notions of (medical) invasiveness and (actual or
      potential) harm has not been systematically discussed nor theoretically grounded,
      despite its importance to clinical-ethical practice. This paper aims to clarify
      the notion of invasiveness beyond the traditional notion of invasiveness as
      breaking skin or inserting mechanical objects into the body. The traditional
      notion of invasiveness is challenged by counterexamples. Three approaches to the 
      notion of disorder applied here are: deviation from what is common; deviation
      from what is considered ideal; and disruption of self-organization. Assuming that
      more extreme measures are related to more harm, all three approaches to the
      notion of disorder suggest that invasiveness is proportional if not identical to 
      harm, and show no clear relation to the traditional notion of invasiveness. In
      conclusion, the notion of invasiveness may best be eliminated from medical
      terminology, replacing it with a detailed understanding of the notion of harm.
FAU - Rudnick, Abraham
AU  - Rudnick A
AD  - Departments of Psychiatry and Philosophy, University of Western Ontario, London, 
      Canada. arudnic2@uwo.ca
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Health Care Anal
JT  - Health care analysis : HCA : journal of health philosophy and policy
JID - 9432537
MH  - *Bioethical Issues
MH  - Humans
MH  - Philosophy, Medical
MH  - Therapeutics/*ethics
EDAT- 2010/04/15 06:00
MHDA- 2011/12/13 00:00
CRDT- 2010/04/15 06:00
PHST- 2010/04/15 06:00 [entrez]
PHST- 2010/04/15 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/s10728-010-0149-5 [doi]
PST - ppublish
SO  - Health Care Anal. 2011 Jun;19(2):99-106. doi: 10.1007/s10728-010-0149-5.


PMID- 20331498
OWN - NLM
STAT- MEDLINE
DCOM- 20110726
LR  - 20161125
IS  - 1552-6569 (Electronic)
IS  - 1051-2284 (Linking)
VI  - 21
IP  - 2
DP  - 2011 Apr
TI  - American Society of Neurophysiologic Monitoring and American Society of
      Neuroimaging joint guidelines for transcranial doppler ultrasonic monitoring.
PG  - 177-83
LID - 10.1111/j.1552-6569.2010.00471.x [doi]
AB  - The American Society of Neurophysiologic Monitoring (ASNM) and American Society
      of Neuroimaging (ASN) Guidelines Committees formed a joint task force and
      developed guidelines to assist in the use of transcranial Doppler (TCD)
      monitoring in the surgical and intensive care settings. Specifically, these
      guidelines: (1) delineate the objectives of TCD monitoring; (2) characterize the 
      responsibilities and behaviors of the sonographer during monitoring; (3) describe
      methodological and ethical issues uniquely relevant to monitoring. The ASNM and
      ASN strongly support the positions that (1) acquisition and interpretation of
      intraoperative TCD ultrasonograms be performed by qualified individuals, (2)
      service providers define their diagnostic criteria and develop on-going
      self-validation programs of these performance criteria in their practices. We
      agree with the guidelines of other professional societies regarding the technical
      and professional qualifications of individuals responsible for TCD signal
      acquisition and interpretation (Class III evidence, Type C recommendation). On
      the basis of current clinical literature and scientific evidence, TCD monitoring 
      is an established monitoring modality for the: (1) assessment of cerebral
      vasomotor reactivity and autoregulation; (2) documentation of the circle of
      Willis functional status; (3) identification of cerebral hypo- and
      hyperperfusion, recanalization and re-occlusion; and (4) detection of cerebral
      emboli (Class II and III evidence, Type B recommendation).
CI  - Copyright (c) 2010 by the American Society of Neuroimaging.
FAU - Edmonds, Harvey L Jr
AU  - Edmonds HL Jr
AD  - Department of Anesthesiology, University of Louisville, Louisville, Kentucky,
      USA.
FAU - Isley, Michael R
AU  - Isley MR
FAU - Sloan, Tod B
AU  - Sloan TB
FAU - Alexandrov, Andrei V
AU  - Alexandrov AV
FAU - Razumovsky, Alexander Y
AU  - Razumovsky AY
LA  - eng
PT  - Journal Article
PT  - Practice Guideline
PL  - United States
TA  - J Neuroimaging
JT  - Journal of neuroimaging : official journal of the American Society of
      Neuroimaging
JID - 9102705
SB  - IM
MH  - Cerebrovascular Disorders/*diagnostic imaging/*physiopathology/therapy
MH  - Humans
MH  - *Intensive Care Units
MH  - *Neurophysiology
MH  - Societies, Medical
MH  - Ultrasonography, Doppler, Transcranial/*standards
MH  - United States
EDAT- 2010/03/25 06:00
MHDA- 2011/07/27 06:00
CRDT- 2010/03/25 06:00
PHST- 2010/03/25 06:00 [entrez]
PHST- 2010/03/25 06:00 [pubmed]
PHST- 2011/07/27 06:00 [medline]
AID - JON471 [pii]
AID - 10.1111/j.1552-6569.2010.00471.x [doi]
PST - ppublish
SO  - J Neuroimaging. 2011 Apr;21(2):177-83. doi: 10.1111/j.1552-6569.2010.00471.x.


PMID- 20217482
OWN - NLM
STAT- MEDLINE
DCOM- 20111202
LR  - 20181113
IS  - 1573-3394 (Electronic)
IS  - 1065-3058 (Linking)
VI  - 19
IP  - 2
DP  - 2011 Jun
TI  - Moral distress among health system managers: exploratory research in two British 
      Columbia health authorities.
PG  - 107-21
LID - 10.1007/s10728-010-0145-9 [doi]
AB  - Moral distress is a concept used to date in clinical literature to describe the
      experience of staff in circumstances in which they are prevented from delivering 
      the kind of bedside care they believe is expected of them, professionally and
      ethically. Our research objective was to determine if this concept has relevance 
      in terms of key health care managerial functions, such as priority setting and
      resource allocation. We conducted interviews and focus groups with mid- and
      senior-level managers in two British Columbia (Canada) health authorities.
      Transcripts were analyzed qualitatively using constant comparison to identify key
      themes related to moral distress. Both mid- and senior-level managers appear to
      experience moral distress, with both similarities and differences in how their
      experiences manifest. Several examples of this concept were identified including 
      the obligation to communicate or 'sell' organizational decisions or policies with
      which a manager personally may disagree and situations where scarce resources
      compel managers to place staff in situations where they meet with predictable and
      potentially avoidable risks. Given that moral distress appears to be a relevant
      issue for at least some health care managers, further research is warranted into 
      its exact nature, prevalence, and possible organizational and personal responses.
FAU - Mitton, Craig
AU  - Mitton C
AD  - Centre for Clinical Epidemiology and Evaluation, Vancouver Coastal Health
      Research Institute, University of British Columbia, Vancouver, Canada.
      craig.mitton@ubc.ca
FAU - Peacock, Stuart
AU  - Peacock S
FAU - Storch, Jan
AU  - Storch J
FAU - Smith, Neale
AU  - Smith N
FAU - Cornelissen, Evelyn
AU  - Cornelissen E
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Health Care Anal
JT  - Health care analysis : HCA : journal of health philosophy and policy
JID - 9432537
MH  - British Columbia
MH  - Decision Making
MH  - Delivery of Health Care/*organization & administration
MH  - Dissent and Disputes
MH  - Female
MH  - Focus Groups
MH  - Health Personnel/*psychology
MH  - Health Priorities
MH  - Humans
MH  - Male
MH  - Morals
MH  - Qualitative Research
MH  - Resource Allocation
EDAT- 2010/03/11 06:00
MHDA- 2011/12/13 00:00
CRDT- 2010/03/11 06:00
PHST- 2010/03/11 06:00 [entrez]
PHST- 2010/03/11 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - 10.1007/s10728-010-0145-9 [doi]
PST - ppublish
SO  - Health Care Anal. 2011 Jun;19(2):107-21. doi: 10.1007/s10728-010-0145-9.


PMID- 20201952
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20211203
IS  - 1399-0012 (Electronic)
IS  - 0902-0063 (Linking)
VI  - 25
IP  - 1
DP  - 2011 Jan-Feb
TI  - Short-term kidney transplant outcomes among African American recipients do not
      predict long-term outcomes: donor pair analysis.
PG  - 69-76
LID - 10.1111/j.1399-0012.2010.01223.x [doi]
AB  - African American (AA) renal transplant recipients have poorer graft survival
      compared to other racial and ethic groups. This study was undertaken to determine
      whether pre-transplant factors and events occurring in the first six months
      post-transplant were predictive of the poorer long-term outcomes in AA
      recipients. To control for kidney quality, a paired analysis of deceased donor
      kidneys in which one donor kidney was transplanted into an adult AA recipient and
      the other was transplanted into an adult Caucasian was undertaken. Cox
      proportional hazard modeling was used to determine the impact of outcome
      variables at six months. Outcomes at six months among the paired recipients were 
      very similar for graft and patient survival, and estimated glomerular filtration 
      rate (GFR). Less than 10% of difference in long-term outcomes was explained by
      differences in the pre-transplant covariates and events in the first six months. 
      Causes of graft failure after six months revealed a two to three times higher
      rate of chronic allograft nephropathy (CAN) and late acute rejection among AA. In
      conclusion, early outcomes after kidney transplant did not predict the poor
      long-term graft survival among AA, and AA recipients appear to be more prone to
      graft loss because of CAN and late acute rejection.
CI  - (c) 2010 John Wiley & Sons A/S.
FAU - Keith, Douglas
AU  - Keith D
AD  - Division of Nephrology, Department of Medicine, University of Virginia,
      Charlottesville, VA 22908, USA. dsk9s@virginia.edu
FAU - Patrie, James T
AU  - Patrie JT
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Denmark
TA  - Clin Transplant
JT  - Clinical transplantation
JID - 8710240
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *African Americans
MH  - Female
MH  - Follow-Up Studies
MH  - Glomerular Filtration Rate
MH  - Graft Rejection/*epidemiology/*etiology
MH  - *Graft Survival
MH  - Humans
MH  - Immunosuppressive Agents/therapeutic use
MH  - Kidney Function Tests
MH  - Kidney Transplantation/*mortality
MH  - Living Donors
MH  - Male
MH  - Middle Aged
MH  - Survival Rate
MH  - Time Factors
MH  - Treatment Outcome
MH  - Whites
MH  - Young Adult
EDAT- 2010/03/06 06:00
MHDA- 2011/06/03 06:00
CRDT- 2010/03/06 06:00
PHST- 2010/03/06 06:00 [entrez]
PHST- 2010/03/06 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
AID - CTR1223 [pii]
AID - 10.1111/j.1399-0012.2010.01223.x [doi]
PST - ppublish
SO  - Clin Transplant. 2011 Jan-Feb;25(1):69-76. doi: 10.1111/j.1399-0012.2010.01223.x.


PMID- 20191322
OWN - NLM
STAT- MEDLINE
DCOM- 20120419
LR  - 20211020
IS  - 1573-6571 (Electronic)
IS  - 0022-4197 (Linking)
VI  - 50
IP  - 4
DP  - 2011 Dec
TI  - Maximal care considerations when treating patients with end-stage heart failure: 
      ethical and procedural quandaries in management of the very sick.
PG  - 872-9
LID - 10.1007/s10943-010-9326-y [doi]
AB  - Deciding who should receive maximal technological treatment options and who
      should not represents an ethical, moral, psychological and medico-legal challenge
      for health care providers. Especially in patients with chronic heart failure, the
      ethical and medico-legal issues associated with providing maximal possible care
      or withholding the same are coming to the forefront. Procedures, such as cardiac 
      transplantation, have strict criteria for adequate candidacy. These criteria for 
      subsequent listing are based on clinical outcome data but also reflect the
      reality of organ shortage. Lack of compliance and non-adherence to lifestyle
      changes represent relative contraindications to heart transplant candidacy.
      Mechanical circulatory support therapy using ventricular assist devices is
      becoming a more prominent therapeutic option for patients with end-stage heart
      failure who are not candidates for transplantation, which also requires strict
      criteria to enable beneficial outcome for the patient. Physicians need to
      critically reflect that in many cases, the patient's best interest might not
      always mean pursuing maximal technological options available. This article
      reflects on the multitude of critical issues that health care providers have to
      face while caring for patients with end-stage heart failure.
FAU - Schwarz, Ernst R
AU  - Schwarz ER
AD  - Division of Cardiology, Cedars Sinai Heart Institute, Cedars Sinai Medical
      Center, 8700 Beverly Boulevard, Suite 6215, Los Angeles, CA 90048, USA.
      ernst.schwarz@cshs.org
FAU - Philip, Kiran J
AU  - Philip KJ
FAU - Simsir, Sinan A
AU  - Simsir SA
FAU - Czer, Lawrence
AU  - Czer L
FAU - Trento, Alfredo
AU  - Trento A
FAU - Finder, Stuart G
AU  - Finder SG
FAU - Cleenewerck, Laurent A
AU  - Cleenewerck LA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Relig Health
JT  - Journal of religion and health
JID - 2985199R
SB  - IM
MH  - Cardiopulmonary Resuscitation/*ethics/psychology
MH  - Disease Management
MH  - Heart Failure/*therapy
MH  - Heart Transplantation/*ethics
MH  - Heart-Assist Devices/*ethics
MH  - Humans
MH  - Patient Selection
MH  - Quality of Life
MH  - Sick Role/*ethics
PMC - PMC3230758
EDAT- 2010/03/02 06:00
MHDA- 2012/04/20 06:00
CRDT- 2010/03/02 06:00
PHST- 2010/03/02 06:00 [entrez]
PHST- 2010/03/02 06:00 [pubmed]
PHST- 2012/04/20 06:00 [medline]
AID - 10.1007/s10943-010-9326-y [doi]
PST - ppublish
SO  - J Relig Health. 2011 Dec;50(4):872-9. doi: 10.1007/s10943-010-9326-y.


PMID- 20190630
OWN - NLM
STAT- MEDLINE
DCOM- 20140605
LR  - 20130917
IS  - 1533-404X (Electronic)
IS  - 0195-7910 (Linking)
VI  - 32
IP  - 3
DP  - 2011 Sep
TI  - Accidental fetal decapitation: a case of medical and ethical mishap.
PG  - 245-7
LID - 10.1097/PAF.0b013e3181d3d9be [doi]
AB  - Blunt trauma to the head and neck of a newborn during delivery process is a rare 
      event. We report a peculiar case of decapitation of a live fetus during
      vacuum-assisted delivery, where excessive traction on the head of the full-term
      macrosomic fetus with shoulder dystocia resulted in overstretching of the neck up
      to the point of decapitation. The ethical considerations related to the case are 
      discussed in light of the policy of complete transparency advocated by the
      medical profession. Despite the existence of regulations regarding full
      disclosure of errors to the medical institution, the Ministry of Health and to
      the patient, medical practitioners are reluctant to divulge all the details of
      adverse events to the patient.
FAU - Hiss, Jehuda
AU  - Hiss J
AD  - From the *The National Centre of Forensic Medicine, the Sackler Faculty of
      Medicine, Tel Aviv University, Tel Aviv, Israel; daggerDivision of Identification
      and Forensic Science, Israel National Police, Head Quarters, Jerusalem, Israel;
      and double daggerDepartment of Obstetric and Gynecology, Assaf Harofeh Medical
      Centre, Tzrifin, Israel.
FAU - Kahana, Tzipi
AU  - Kahana T
FAU - Burshtein, Irad
AU  - Burshtein I
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Am J Forensic Med Pathol
JT  - The American journal of forensic medicine and pathology
JID - 8108948
SB  - IM
MH  - Adult
MH  - Cervical Vertebrae/injuries/pathology
MH  - *Decapitation
MH  - Dystocia/*etiology
MH  - Esophagus/injuries/pathology
MH  - Female
MH  - Fetal Macrosomia/*complications
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - Neck Muscles/injuries/pathology
MH  - Pregnancy
MH  - Shoulder
MH  - Trachea/injuries/pathology
MH  - Vacuum Extraction, Obstetrical/*adverse effects
EDAT- 2010/03/02 06:00
MHDA- 2014/06/06 06:00
CRDT- 2010/03/02 06:00
PHST- 2010/03/02 06:00 [entrez]
PHST- 2010/03/02 06:00 [pubmed]
PHST- 2014/06/06 06:00 [medline]
AID - 10.1097/PAF.0b013e3181d3d9be [doi]
PST - ppublish
SO  - Am J Forensic Med Pathol. 2011 Sep;32(3):245-7. doi:
      10.1097/PAF.0b013e3181d3d9be.


PMID- 20091763
OWN - NLM
STAT- MEDLINE
DCOM- 20110621
LR  - 20211020
IS  - 1099-1050 (Electronic)
IS  - 1057-9230 (Linking)
VI  - 20
IP  - 2
DP  - 2011 Feb
TI  - Dangerous omissions: the consequences of ignoring decision uncertainty.
PG  - 212-24
LID - 10.1002/hec.1586 [doi]
AB  - Institutions with the responsibility for making adoption (reimbursement)
      decisions in health care often lack the remit to demand or commission further
      research: adoption decisions are their only policy instrument. The decision to
      adopt a technology also influences the prospects of acquiring further evidence
      because the incentives to conduct research are reduced and the ethical basis of
      further clinical trials maybe undermined. In these circumstances the decision
      maker must consider whether the benefits of immediate access to a technology
      exceeds the value of the evidence which maybe forgone for future patients. We
      outline how these expected opportunity losses can be established from the
      perspective of a societal decision maker with and without the remit to commission
      research, and demonstrate how these considerations change the appropriate
      decision rules in cost-effectiveness analysis. Importantly, we identify those
      circumstances in which the approval of a technology that is expected to be
      cost-effective should be withheld, i.e. when an 'only in research' recommendation
      should be made. We demonstrate that a sufficient condition for immediate adoption
      of a technology can provide incentives for manufacturers to reduce the price or
      provide additional supporting evidence. However, decisions based solely on
      expected net benefit provide no such incentives, may undermine the evidence base 
      for future clinical practice and reduce expected net health benefits for the
      patient population.
FAU - Griffin, Susan C
AU  - Griffin SC
AD  - Centre for Health Economics, University of York, UK. scg3@york.ac.uk
FAU - Claxton, Karl P
AU  - Claxton KP
FAU - Palmer, Stephen J
AU  - Palmer SJ
FAU - Sculpher, Mark J
AU  - Sculpher MJ
LA  - eng
GR  - G0802659/MRC_/Medical Research Council/United Kingdom
GR  - MC_U145079308/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Health Econ
JT  - Health economics
JID - 9306780
SB  - IM
MH  - Biomedical Technology
MH  - Cost-Benefit Analysis
MH  - *Decision Making
MH  - Humans
MH  - *Policy Making
MH  - Quality-Adjusted Life Years
MH  - Technology Assessment, Biomedical
MH  - *Uncertainty
EDAT- 2010/01/22 06:00
MHDA- 2011/06/22 06:00
CRDT- 2010/01/22 06:00
PHST- 2010/01/22 06:00 [entrez]
PHST- 2010/01/22 06:00 [pubmed]
PHST- 2011/06/22 06:00 [medline]
AID - 10.1002/hec.1586 [doi]
PST - ppublish
SO  - Health Econ. 2011 Feb;20(2):212-24. doi: 10.1002/hec.1586.


PMID- 20063371
OWN - NLM
STAT- MEDLINE
DCOM- 20110311
LR  - 20181201
IS  - 1098-108X (Electronic)
IS  - 0276-3478 (Linking)
VI  - 44
IP  - 1
DP  - 2011 Jan
TI  - The effectiveness of a day program for the treatment of adolescent anorexia
      nervosa.
PG  - 29-38
LID - 10.1002/eat.20789 [doi]
AB  - OBJECTIVE: The risks of anorexia nervosa (AN) are well established. Despite its
      severity, little certainty exists for practitioners, with ethical and financial
      limitations yielding few controlled studies establishing effective treatments.
      Thus, other methods of establishing treatment effectiveness are necessary. This
      study presents preliminary results of an open clinical trial of a day program for
      adolescents with AN. METHOD: Participants were 26 anorectic females, 12-18 years,
      who completed the "Transition Program." RESULTS: Significant change emerged on
      measures of weight gain, and behavioral and attitudinal measures of eating
      pathology. Large effect sizes were evident for weight gain at 6 month follow-up. 
      Preliminary trends suggest that treatment gains on these and other measures of
      eating pathology were maintained at 6 month follow-up. DISCUSSION: Preliminary
      results support day program treatment for adolescents with mild-moderately severe
      eating disorders. Present outcomes are discussed with respect to the dearth of
      efficacious treatment options for adolescents.
CI  - Copyright (c) 2010 Wiley Periodicals, Inc.
FAU - Goldstein, Mandy
AU  - Goldstein M
AD  - Department of Psychology, Centre for Emotional Health, Macquarie University,
      Sydney, Australia. mandy.goldstein@psy.mq.edu.au
FAU - Peters, Lorna
AU  - Peters L
FAU - Baillie, Andrew
AU  - Baillie A
FAU - McVeagh, Patricia
AU  - McVeagh P
FAU - Minshall, Gerri
AU  - Minshall G
FAU - Fitzjames, Dianne
AU  - Fitzjames D
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Int J Eat Disord
JT  - The International journal of eating disorders
JID - 8111226
SB  - IM
MH  - Adolescent
MH  - Anorexia Nervosa/*therapy
MH  - Child
MH  - *Cognitive Behavioral Therapy
MH  - Female
MH  - Humans
MH  - *Outpatients
MH  - Treatment Outcome
MH  - Weight Gain
EDAT- 2010/01/12 06:00
MHDA- 2011/03/12 06:00
CRDT- 2010/01/12 06:00
PHST- 2010/01/12 06:00 [entrez]
PHST- 2010/01/12 06:00 [pubmed]
PHST- 2011/03/12 06:00 [medline]
AID - 10.1002/eat.20789 [doi]
PST - ppublish
SO  - Int J Eat Disord. 2011 Jan;44(1):29-38. doi: 10.1002/eat.20789.


PMID- 20051674
OWN - NLM
STAT- MEDLINE
DCOM- 20110419
LR  - 20101214
IS  - 1662-8063 (Electronic)
IS  - 1662-4246 (Linking)
VI  - 14
IP  - 1
DP  - 2011
TI  - Guiding policy decisions for genetic screening: developing a systematic and
      transparent approach.
PG  - 9-16
LID - 10.1159/000272898 [doi]
AB  - With the ever-widening gap between what is technologically possible and services 
      available, jurisdictions around the world are faced with complex decisions
      regarding the introduction and expansion of genetic screening programs. A series 
      of literature reviews and consultations with stakeholders and experts led to the 
      development of a decision support guide for genetic screening policy-making. This
      involved establishing a preliminary list of core criteria synthesized from the
      growing literature on genetic screening, which was then transformed through a
      series of consultations into a more elaborate decision guide. Although certain
      perennial challenges in genetic screening policy-making remain, the decision
      support guide aims to promote a fair and evidence-informed process that makes
      explicit the ethical dilemmas often inherent to such policy decisions.
CI  - Copyright (c) 2009 S. Karger AG, Basel.
FAU - Andermann, A
AU  - Andermann A
AD  - McGill University, Montreal, Que., Canada. anne.andermann@mail.mcgill.ca
FAU - Blancquaert, I
AU  - Blancquaert I
FAU - Beauchamp, S
AU  - Beauchamp S
FAU - Costea, I
AU  - Costea I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091229
PL  - Switzerland
TA  - Public Health Genomics
JT  - Public health genomics
JID - 101474167
SB  - IM
MH  - Decision Making, Organizational
MH  - Genetic Testing/*legislation & jurisprudence/organization & administration
MH  - Guidelines as Topic
MH  - Health Policy
MH  - Humans
MH  - *Policy Making
EDAT- 2010/01/07 06:00
MHDA- 2011/04/20 06:00
CRDT- 2010/01/07 06:00
PHST- 2009/02/26 00:00 [received]
PHST- 2009/08/24 00:00 [accepted]
PHST- 2010/01/07 06:00 [entrez]
PHST- 2010/01/07 06:00 [pubmed]
PHST- 2011/04/20 06:00 [medline]
AID - 000272898 [pii]
AID - 10.1159/000272898 [doi]
PST - ppublish
SO  - Public Health Genomics. 2011;14(1):9-16. doi: 10.1159/000272898. Epub 2009 Dec
      29.


PMID- 20047590
OWN - NLM
STAT- MEDLINE
DCOM- 20111019
LR  - 20211028
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 25
IP  - 6
DP  - 2011 Jul
TI  - The contributions of empirical evidence to socio-ethical debates on fresh embryo 
      donation for human embryonic stem cell research.
PG  - 334-41
LID - 10.1111/j.1467-8519.2009.01792.x [doi]
AB  - This article is a response to McLeod and Baylis (2007) who speculate on the
      dangers of requesting fresh 'spare' embryos from IVF patients for human embryonic
      stem cell (hESC) research, particularly when those embryos are good enough to be 
      transferred back to the woman. They argue that these embryos should be frozen
      instead. We explore what is meant by 'spare' embryos. We then provide empirical
      evidence, from a study of embryo donation and of embryo donors' views, to
      substantiate some of their speculations about the problems associated with
      requesting fresh embryos. However, we also question whether such problems are
      resolved by embryo freezing, since further empirical evidence suggests that this 
      raises other social and ethical problems for patients. There is little evidence
      that the request for embryos for research, in itself, causes patients distress.
      We suggest, however, that no requests for fresh embryos should be made in the
      first cycle of IVF treatment. Deferring the request to a later cycle ensures that
      potential donors are better informed (by experience and reflection) about the
      possible destinations of their embryos and about the definition of 'spare
      embryos'. Both this article, and that by McLeod and Baylis, emphasize the need to
      consider the views and experiences of embryo donors when evaluating the ethics of
      embryo donation for hESC research.
CI  - (c) 2009 Blackwell Publishing Ltd.
FAU - Haimes, Erica
AU  - Haimes E
AD  - Newcastle University, Newcastle upon Tyne NE1 4JH. erica.haimes@ncl.ac.uk
FAU - Taylor, Ken
AU  - Taylor K
LA  - eng
GR  - G0701109/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Comment
DEP - 20091227
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
CON - Bioethics. 2007 Nov;21(9):465-77. PMID: 17927623
MH  - *Coercion
MH  - *Cryopreservation
MH  - Embryo Research/*ethics
MH  - Female
MH  - Fertilization in Vitro/*methods
MH  - Humans
MH  - Living Donors/*psychology
MH  - *Stem Cells
PMC - PMC3130929
EDAT- 2010/01/06 06:00
MHDA- 2011/10/20 06:00
CRDT- 2010/01/06 06:00
PHST- 2010/01/06 06:00 [entrez]
PHST- 2010/01/06 06:00 [pubmed]
PHST- 2011/10/20 06:00 [medline]
AID - BIOT1792 [pii]
AID - 10.1111/j.1467-8519.2009.01792.x [doi]
PST - ppublish
SO  - Bioethics. 2011 Jul;25(6):334-41. doi: 10.1111/j.1467-8519.2009.01792.x. Epub
      2009 Dec 27.


PMID- 20047589
OWN - NLM
STAT- MEDLINE
DCOM- 20111019
LR  - 20110608
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 25
IP  - 6
DP  - 2011 Jul
TI  - Predictive testing and existential absurdity: resonances between experiences
      around genetic diagnosis and the philosophy of Albert Camus.
PG  - 342-50
LID - 10.1111/j.1467-8519.2009.01795.x [doi]
AB  - Predictive genetic testing may confront those affected with difficult life
      situations that they have not experienced before. These life situations may be
      interpreted as 'absurd'. In this paper we present a case study of a predictive
      test situation, showing the perspective of a woman going through the process of
      deciding for or against taking the test, and struggling with feelings of
      alienation. To interpret her experiences, we refer to the concept of absurdity,
      developed by the French Philosopher Albert Camus. Camus' writings on absurdity
      appear to resonate with patients' stories when they talk about their body and
      experiences of illness. In this paper we draw on Camus' philosophical essay 'The 
      Myth of Sisyphus' (1942), and compare the absurd experiences of Sisyphus with the
      interviewee's story. This comparison opens up a field of ethical reflection. We
      demonstrate that Camus' concept of absurdity offers a new and promising approach 
      to understanding the fragility of patients' situations, especially in the field
      of predictive testing. We show that people affected might find new meaning
      through narratives that help them to reconstruct the absurd without totally
      overcoming it. In conclusion, we will draw out some normative consequences of our
      narrative approach.
CI  - (c) 2009 Blackwell Publishing Ltd.
FAU - Porz, Rouven
AU  - Porz R
AD  - Ethics Unit in the University Hospital in Bern, Switzerland University of
      Amsterdam. Rouven.Porz@insel.ch
FAU - Widdershoven, Guy
AU  - Widdershoven G
LA  - eng
PT  - Biography
PT  - Historical Article
PT  - Journal Article
DEP - 20091227
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - *Attitude to Health
MH  - *Bioethical Issues
MH  - Famous Persons
MH  - Female
MH  - Genetic Testing/*ethics/psychology
MH  - History, 20th Century
MH  - Humans
MH  - Huntington Disease/*diagnosis/psychology
MH  - *Philosophy/history
PS  - Camus A
FPS - Camus, Albert
EDAT- 2010/01/06 06:00
MHDA- 2011/10/20 06:00
CRDT- 2010/01/06 06:00
PHST- 2010/01/06 06:00 [entrez]
PHST- 2010/01/06 06:00 [pubmed]
PHST- 2011/10/20 06:00 [medline]
AID - BIOT1795 [pii]
AID - 10.1111/j.1467-8519.2009.01795.x [doi]
PST - ppublish
SO  - Bioethics. 2011 Jul;25(6):342-50. doi: 10.1111/j.1467-8519.2009.01795.x. Epub
      2009 Dec 27.


PMID- 20044108
OWN - NLM
STAT- MEDLINE
DCOM- 20111027
LR  - 20110606
IS  - 1578-8989 (Electronic)
IS  - 0025-7753 (Linking)
VI  - 137
IP  - 1
DP  - 2011 Jun 11
TI  - [Ethics on genetic research (2). Genetic susceptibility studies].
PG  - 22-6
LID - 10.1016/j.medcli.2009.10.044 [doi]
FAU - Ayuso, Carmen
AU  - Ayuso C
AD  - Servicio de Genetica, Fundacion Jimenez Diaz/CIBERER, Madrid, Espana.
      cayuso@fjd.es
FAU - Telleria, Juan Jose
AU  - Telleria JJ
FAU - Tejedor, Juan Carlos
AU  - Tejedor JC
FAU - Gracia, Diego
AU  - Gracia D
LA  - spa
PT  - Journal Article
TT  - Etica en investigacion genetica (2). Estudios de susceptibilidad.
DEP - 20091230
PL  - Spain
TA  - Med Clin (Barc)
JT  - Medicina clinica
JID - 0376377
SB  - IM
MH  - *Genetic Predisposition to Disease
MH  - Genetic Research/*ethics
MH  - Humans
EDAT- 2010/01/02 06:00
MHDA- 2011/10/28 06:00
CRDT- 2010/01/02 06:00
PHST- 2009/09/03 00:00 [received]
PHST- 2009/10/19 00:00 [revised]
PHST- 2009/10/22 00:00 [accepted]
PHST- 2010/01/02 06:00 [entrez]
PHST- 2010/01/02 06:00 [pubmed]
PHST- 2011/10/28 06:00 [medline]
AID - S0025-7753(09)01561-9 [pii]
AID - 10.1016/j.medcli.2009.10.044 [doi]
PST - ppublish
SO  - Med Clin (Barc). 2011 Jun 11;137(1):22-6. doi: 10.1016/j.medcli.2009.10.044. Epub
      2009 Dec 30.


PMID- 20044101
OWN - NLM
STAT- MEDLINE
DCOM- 20110920
LR  - 20131121
IS  - 1578-8989 (Electronic)
IS  - 0025-7753 (Linking)
VI  - 136
IP  - 15
DP  - 2011 May 28
TI  - [Ethics on genetic research (1). Pharmacogenetic studies].
PG  - 678-82
LID - 10.1016/j.medcli.2009.10.043 [doi]
FAU - Ayuso, Carmen
AU  - Ayuso C
AD  - Servicio de Genetica, Fundacion Jimenez Diaz, CIBERER, Madrid, Espana.
      cayuso@fjd.es
FAU - Abad-Santos, Francisco
AU  - Abad-Santos F
FAU - Dal-Re, Rafael
AU  - Dal-Re R
FAU - Gracia, Diego
AU  - Gracia D
LA  - spa
PT  - Journal Article
PT  - Review
TT  - Etica en investigacion genetica (1). Estudios farmacogeneticos.
DEP - 20091230
PL  - Spain
TA  - Med Clin (Barc)
JT  - Medicina clinica
JID - 0376377
SB  - IM
MH  - Biological Specimen Banks/ethics/legislation & jurisprudence
MH  - Clinical Trials as Topic/ethics
MH  - Confidentiality/ethics/legislation & jurisprudence
MH  - Drug-Related Side Effects and Adverse Reactions/genetics/prevention & control
MH  - Ethics Committees
MH  - Ethics, Institutional
MH  - *Ethics, Research
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Informed Consent/ethics/legislation & jurisprudence
MH  - Moral Obligations
MH  - Ownership/*ethics/legislation & jurisprudence
MH  - Patient Selection
MH  - Pharmacogenetics/*ethics
MH  - Spain
MH  - Specimen Handling/ethics
EDAT- 2010/01/02 06:00
MHDA- 2011/09/21 06:00
CRDT- 2010/01/02 06:00
PHST- 2009/09/03 00:00 [received]
PHST- 2009/10/19 00:00 [revised]
PHST- 2009/10/22 00:00 [accepted]
PHST- 2010/01/02 06:00 [entrez]
PHST- 2010/01/02 06:00 [pubmed]
PHST- 2011/09/21 06:00 [medline]
AID - S0025-7753(09)01560-7 [pii]
AID - 10.1016/j.medcli.2009.10.043 [doi]
PST - ppublish
SO  - Med Clin (Barc). 2011 May 28;136(15):678-82. doi: 10.1016/j.medcli.2009.10.043.
      Epub 2009 Dec 30.


PMID- 21800936
OWN - NLM
STAT- MEDLINE
DCOM- 20120619
LR  - 20181023
IS  - 1091-3734 (Electronic)
IS  - 1091-3734 (Linking)
VI  - 16
IP  - 1
DP  - 2011 Jan 31
TI  - Compassion practice by Ugandan nurses who provide HIV care.
PG  - 5
LID - 10.3912/OJIN.Vol16No01Man05 [doi]
AB  - Compassion is fundamental to ethical nursing practice; it represents a commitment
      to acknowledge and respond to the suffering of the patient. Many structural,
      economic, and sociopolitical challenges confront Ugandan nurses in their efforts 
      to incorporate compassion into their care of persons with HIV illness. After
      reviewing the literature related to compassion fatigue, the author describes
      nursing in sub-Saharan Africa and presents a qualitative study exploring the
      impact of education on 24 nurses' lives, including their capacity to avoid or
      mitigate the development of compassion fatigue. Data were collected through
      interviews, observation, and focus group discussions. Findings illustrate the
      barriers participants faced in providing competent care and the liberating
      effects of new knowledge and skills. Engaging in meaningful relationships,
      maintaining hopeful attitudes, and advocating for the profession were found to
      transform and affirm the nurses' approach toward their work and enhance their
      experiences of compassion satisfaction. The author discusses the unique aspects
      of the experience of compassion among Ugandan nurses caring for persons with HIV 
      illness.
FAU - Harrowing, Jean N
AU  - Harrowing JN
AD  - University of Lethbridge, Alberta, Canada. harrjn@uleth.ca
LA  - eng
PT  - Journal Article
DEP - 20110131
PL  - United States
TA  - Online J Issues Nurs
JT  - Online journal of issues in nursing
JID - 9806525
SB  - IM
MH  - Adaptation, Psychological
MH  - Burnout, Professional/*prevention & control/*psychology
MH  - *Empathy
MH  - Fatigue/*prevention & control/*psychology
MH  - Female
MH  - HIV Infections/*nursing
MH  - Humans
MH  - Interviews as Topic
MH  - Nurse-Patient Relations
MH  - Nurses/*psychology
MH  - Qualitative Research
MH  - Uganda
EDAT- 2010/01/01 00:00
MHDA- 2012/06/20 06:00
CRDT- 2011/08/02 06:00
PHST- 2011/08/02 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2012/06/20 06:00 [medline]
AID - Vol-16-2011/No1-Jan-2011/Compassion-Practice-and-HIV-Care-.aspx [pii]
AID - 10.3912/OJIN.Vol16No01Man05 [doi]
PST - epublish
SO  - Online J Issues Nurs. 2011 Jan 31;16(1):5. doi: 10.3912/OJIN.Vol16No01Man05.


PMID- 21686236
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20211020
IS  - 0065-7778 (Print)
IS  - 0065-7778 (Linking)
VI  - 122
DP  - 2011
TI  - Neuroethics, neuroimaging, and disorders of consciousness: promise or peril?
PG  - 336-46
AB  - The advent of powerful neuroimaging tools such as functional magnetic resonance
      imaging (fMRI) and positron emission tomography (PET) has begun to redefine how
      we diagnose, define, and understand disorders of consciousness such as the
      vegetative and minimally conscious states. In my paper, I review how research
      using these methods is both elucidating these brain states and creating
      diagnostic dilemmas related to their classification as the specificity and
      sensitivity of traditional behavior-based assessments are weighed against
      sensitive but not yet fully validated neuroimaging data. I also consider how
      these methods are being studied as potential communication vectors for
      therapeutic use in subjects who heretofore have been thought to be unresponsive
      or minimally conscious. I conclude by considering the ethical challenges posed by
      novel diagnostic and therapeutic neuroimaging applications and contextualize
      these scientific developments against the broader needs of patients and families 
      touched by severe brain injury.
FAU - Fins, Joseph J
AU  - Fins JJ
AD  - Division of Medical Ethics, New York Presbyterian-Weill Cornell Medical Center,
      435 East 70th Street, Suite 4-J, New York, NY 10021, USA. jjfins@med.cornell.edu
LA  - eng
GR  - UL1-RR024966/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Trans Am Clin Climatol Assoc
JT  - Transactions of the American Clinical and Climatological Association
JID - 7507559
SB  - IM
MH  - Animals
MH  - Brain/*physiopathology
MH  - Brain Death/diagnosis/physiopathology
MH  - *Brain Mapping/ethics/methods
MH  - Coma/diagnosis
MH  - *Consciousness
MH  - Diagnostic Errors
MH  - *Diagnostic Imaging/ethics/methods
MH  - *Diagnostic Techniques, Neurological/ethics
MH  - Humans
MH  - Patient Rights
MH  - Persistent Vegetative State/diagnosis/physiopathology
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Recovery of Function
MH  - Sensitivity and Specificity
MH  - Unconsciousness/classification/*diagnosis/physiopathology
PMC - PMC3116331
EDAT- 2010/01/01 00:00
MHDA- 2011/10/01 06:00
CRDT- 2011/06/21 06:00
PHST- 2011/06/21 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
PST - ppublish
SO  - Trans Am Clin Climatol Assoc. 2011;122:336-46.


PMID- 20012896
OWN - NLM
STAT- MEDLINE
DCOM- 20120316
LR  - 20211203
IS  - 1573-6814 (Electronic)
IS  - 1389-9333 (Linking)
VI  - 12
IP  - 4
DP  - 2011 Nov
TI  - Human tissues for research purposes: a conference in the House of Lords.
PG  - 329-31
LID - 10.1007/s10561-009-9167-7 [doi]
AB  - The challenges to using human tissues in research are many and varied. However,
      there is little consensus on how concerns raised by researchers should be
      addressed, and who should be responsible for ensuring that patients continue to
      benefit from medical research carried out using human tissues which have been
      ethically donated or collected after surgery, or where organs donated for
      transplant are unsuitable for this purpose. A conference in the House of Lords
      sought to bring together stakeholders from all areas of human tissue research to 
      discuss the problems experienced, share solutions, and form a Working Party to
      carry the conference momentum forward into action in the near future.
FAU - Clotworthy, Margaret
AU  - Clotworthy M
AD  - Safer Medicines Trust, London, UK. margaret@safermedicines.org
LA  - eng
PT  - Congress
PT  - Research Support, Non-U.S. Gov't
DEP - 20091213
PL  - Netherlands
TA  - Cell Tissue Bank
JT  - Cell and tissue banking
JID - 100965121
SB  - IM
MH  - *Biomedical Research
MH  - Humans
MH  - *Tissue Banks/economics
MH  - Tissue and Organ Procurement
MH  - Translational Research, Biomedical
MH  - United Kingdom
EDAT- 2009/12/17 06:00
MHDA- 2012/03/17 06:00
CRDT- 2009/12/17 06:00
PHST- 2009/11/27 00:00 [received]
PHST- 2009/11/30 00:00 [accepted]
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2012/03/17 06:00 [medline]
AID - 10.1007/s10561-009-9167-7 [doi]
PST - ppublish
SO  - Cell Tissue Bank. 2011 Nov;12(4):329-31. doi: 10.1007/s10561-009-9167-7. Epub
      2009 Dec 13.


PMID- 20004552
OWN - NLM
STAT- MEDLINE
DCOM- 20110113
LR  - 20220408
IS  - 1878-5921 (Electronic)
IS  - 0895-4356 (Linking)
VI  - 64
IP  - 1
DP  - 2011 Jan
TI  - Moving knowledge to action through dissemination and exchange.
PG  - 25-31
LID - 10.1016/j.jclinepi.2009.08.013 [doi]
AB  - OBJECTIVE: The objective of this article is to discuss the knowledge
      dissemination and exchange components of the knowledge translation process that
      includes synthesis, dissemination, exchange, and ethically sound application of
      knowledge. This article presents and discusses approaches to knowledge
      dissemination and exchange and provides a summary of factors that appear to
      influence the effectiveness of these processes. It aims to provide practical
      information for researchers and knowledge users as they consider what to include 
      in dissemination and exchange plans developed as part of grant applications.
      STUDY DESIGN AND SETTING: Not relevant. RESULTS AND CONCLUSIONS: Dissemination is
      targeting research findings to specific audiences. Dissemination activities
      should be carefully and appropriately considered and outlined in a dissemination 
      plan focused on the needs of the audience who will use the knowledge. Researchers
      should engage knowledge users to craft messages and help disseminate research
      findings. Knowledge brokers, networks, and communities of practice hold promise
      as innovative ways to disseminate and facilitate the application of knowledge.
      Knowledge exchange or integrated knowledge translation involves active
      collaboration and exchange between researchers and knowledge users throughout the
      research process.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Gagnon, Michelle L
AU  - Gagnon ML
AD  - Knowledge Translation Portfolio, CIHR, 160 Elgin Street, 9th Floor Address
      Locator 4809A, Ottawa, Ontario K1A0W9, Canada. michelle.gagnon@cihr-irsc.gc.ca
LA  - eng
PT  - Journal Article
DEP - 20091211
PL  - United States
TA  - J Clin Epidemiol
JT  - Journal of clinical epidemiology
JID - 8801383
SB  - IM
MH  - Evidence-Based Medicine
MH  - Health Knowledge, Attitudes, Practice
MH  - Health Services Research/*methods
MH  - Humans
MH  - Information Dissemination/*methods
MH  - Knowledge
MH  - Research Support as Topic
EDAT- 2009/12/17 06:00
MHDA- 2011/01/14 06:00
CRDT- 2009/12/17 06:00
PHST- 2009/02/01 00:00 [received]
PHST- 2009/07/02 00:00 [revised]
PHST- 2009/08/16 00:00 [accepted]
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2011/01/14 06:00 [medline]
AID - S0895-4356(09)00243-1 [pii]
AID - 10.1016/j.jclinepi.2009.08.013 [doi]
PST - ppublish
SO  - J Clin Epidemiol. 2011 Jan;64(1):25-31. doi: 10.1016/j.jclinepi.2009.08.013. Epub
      2009 Dec 11.


PMID- 20002073
OWN - NLM
STAT- MEDLINE
DCOM- 20110823
LR  - 20211020
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 25
IP  - 4
DP  - 2011 May
TI  - Will biomedical enhancements undermine solidarity, responsibility, equality and
      autonomy?
PG  - 177-84
LID - 10.1111/j.1467-8519.2009.01779.x [doi]
AB  - Prominent thinkers such as Jurgen Habermas and Michael Sandel are warning that
      biomedical enhancements will undermine fundamental political values. Yet whether 
      biomedical enhancements will undermine such values depends on how biomedical
      enhancements will function, how they will be administered and to whom. Since only
      few enhancements are obtainable, it is difficult to tell whether these
      predictions are sound. Nevertheless, such warnings are extremely valuable. As a
      society we must, at the very least, be aware of developments that could have
      harmful consequences. Indeed, if important values were to be jeopardized, we
      should take appropriate measures to protect them. This paper focuses on four
      central values: solidarity, personal responsibility, equality and autonomy. It
      delineates the conditions under which biomedical enhancements would undermine
      these values. It also details the circumstances under which these values would be
      unaffected by enhancements as well as those under which they would be promoted.
      Specifying these conditions is valuable; it would enable society to prepare
      appropriate ethical guidelines and policy responses in advance.
CI  - Published 2009. This article is a US Government work and is in the public domain 
      in the USA.
FAU - Lev, Ori
AU  - Lev O
AD  - Social and Behavioral Research Branch, National Human Genome Research Institute, 
      National Institutes of Health, Bethesda, MD 20892-2073, USA. levo@mail.nih.gov
LA  - eng
GR  - Z99 OD999999/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
CIN - Bioethics. 2011 May;25(4):ii. PMID: 21480931
MH  - Biomedical Enhancement/*ethics
MH  - *Democracy
MH  - Humans
MH  - Personal Autonomy
MH  - Social Identification
MH  - Social Justice
MH  - Social Responsibility
MH  - *Social Values
PMC - PMC2888791
MID - NIHMS161916
EDAT- 2009/12/17 06:00
MHDA- 2011/08/24 06:00
CRDT- 2009/12/17 06:00
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2011/08/24 06:00 [medline]
AID - BIOT1779 [pii]
AID - 10.1111/j.1467-8519.2009.01779.x [doi]
PST - ppublish
SO  - Bioethics. 2011 May;25(4):177-84. doi: 10.1111/j.1467-8519.2009.01779.x.


PMID- 20002070
OWN - NLM
STAT- MEDLINE
DCOM- 20110608
LR  - 20110202
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 25
IP  - 3
DP  - 2011 Mar
TI  - The ongoing charity of organ donation. Contemporary English Sunni fatwas on organ
      donation and blood transfusion.
PG  - 167-75
LID - 10.1111/j.1467-8519.2009.01782.x [doi]
AB  - BACKGROUND: Empirical studies in Muslim communities on organ donation and blood
      transfusion show that Muslim counsellors play an important role in the decision
      process. Despite the emerging importance of online English Sunni fatwas, these
      fatwas on organ donation and blood transfusion have hardly been studied, thus
      creating a gap in our knowledge of contemporary Islamic views on the subject.
      METHOD: We analysed 70 English Sunni e-fatwas and subjected them to an in-depth
      text analysis in order to reveal the key concepts in the Islamic ethical
      framework regarding organ donation and blood transfusion. RESULTS: All 70 fatwas 
      allow for organ donation and blood transfusion. Autotransplantation is no problem
      at all if done for medical reasons. Allotransplantation, both from a living and a
      dead donor, appears to be possible though only in quite restricted ways.
      Xenotransplantation is less often mentioned but can be allowed in case of
      necessity. Transplantation in general is seen as an ongoing form of charity.
      Nearly half of the fatwas allowing blood transfusion do so without mentioning any
      restriction or problem whatsoever. The other half of the fatwas on transfusion
      contain the same conditional approval as found in the arguments pro organ
      transplantation. CONCLUSION: Our findings are very much in line with the
      international literature on the subject. We found two new elements: debates on
      the definition of the moment of death are hardly mentioned in the English Sunni
      fatwas and organ donation and blood transfusion are presented as an ongoing form 
      of charity.
CI  - (c) 2009 Blackwell Publishing Ltd.
FAU - Van den Branden, Stef
AU  - Van den Branden S
AD  - Catholic University of Leuven, Belgium. stef.vandenbranden@theo.kuleuven.be
FAU - Broeckaert, Bert
AU  - Broeckaert B
LA  - eng
PT  - Journal Article
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - *Blood Transfusion
MH  - Cadaver
MH  - Humans
MH  - *Islam
MH  - Living Donors
MH  - *Religion and Medicine
MH  - Tissue and Organ Procurement/*ethics
MH  - Transplantation, Autologous/ethics
MH  - Transplantation, Homologous/ethics
EDAT- 2009/12/17 06:00
MHDA- 2011/06/09 06:00
CRDT- 2009/12/17 06:00
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2011/06/09 06:00 [medline]
AID - BIOT1782 [pii]
AID - 10.1111/j.1467-8519.2009.01782.x [doi]
PST - ppublish
SO  - Bioethics. 2011 Mar;25(3):167-75. doi: 10.1111/j.1467-8519.2009.01782.x.


PMID- 20002069
OWN - NLM
STAT- MEDLINE
DCOM- 20111019
LR  - 20110608
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 25
IP  - 6
DP  - 2011 Jul
TI  - Navigating the murky intersection between clinical and organizational ethics: a
      hybrid case taxonomy.
PG  - 320-5
LID - 10.1111/j.1467-8519.2009.01783.x [doi]
AB  - Ethical challenges that arise within healthcare delivery institutions are
      currently categorized as either clinical or organizational, based on the type of 
      issue. Despite this common binary issue-based methodology, empirical study and
      increasing academic dialogue indicate that a clear line cannot easily be drawn
      between organizational and clinical ethics. Disagreement around end-of-life
      treatments, for example, often spawn value differences amongst parties at both
      organizational and clinical levels and requires a resolution to address both the 
      case at hand and large-scale underlying system-level confounders. I refer to
      issues that contain elements of both clinical and organizational issues as
      hybrids and propose a new taxonomy to characterize hybrid cases. I contend that
      salient contextual features of an ethical issue, such as where it is identified, 
      who it impacts and where it is ideally resolved in relation to its scope of
      impact, should inform procedure. Implementation of a Hybrid taxonomy viewing
      ethical issues as existing on a continuum furthers that end. The primary goals
      are to 1) systematize thinking about ethical issues that arise within healthcare 
      delivery institutions and 2) allow the content of the ethical challenge to drive 
      the process, rather than continuing to rely on the traditional binary issue-based
      choice. Failure to capture the complexity of hybrid situations perpetuates
      incomplete information and ultimately an inchoate resolution that creates more
      questions than answers.
CI  - (c) 2009 Blackwell Publishing Ltd.
FAU - Bean, Sally
AU  - Bean S
AD  - Sunnybrook Health Sciences Centre and University of Toronto, Toronto, ON, Canada.
      sally.bean@utoronto.ca
LA  - eng
PT  - Journal Article
DEP - 20091130
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - *Bioethical Issues
MH  - *Ethics, Clinical
MH  - *Ethics, Institutional
MH  - Health Services Accessibility/*ethics
MH  - Hospitals
MH  - Humans
MH  - Organizational Policy
EDAT- 2009/12/17 06:00
MHDA- 2011/10/20 06:00
CRDT- 2009/12/17 06:00
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2011/10/20 06:00 [medline]
AID - BIOT1783 [pii]
AID - 10.1111/j.1467-8519.2009.01783.x [doi]
PST - ppublish
SO  - Bioethics. 2011 Jul;25(6):320-5. doi: 10.1111/j.1467-8519.2009.01783.x. Epub 2009
      Nov 30.


PMID- 20002068
OWN - NLM
STAT- MEDLINE
DCOM- 20110928
LR  - 20110516
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 25
IP  - 5
DP  - 2011 Jun
TI  - The race toward 'ethically universally acceptable' human pluripotent
      (embryonic-like) stem cells: only a problem of sources?
PG  - 260-6
LID - 10.1111/j.1467-8519.2009.01784.x [doi]
AB  - Over the past few years, several proposals aimed at procuring human pluripotent
      (embryonic-like) stem cells without involving the destruction of a human embryo
      have been proposed and widely discussed. This article focuses on a basic aspect
      of the debate, namely the plausibility of one or more of these new proposals
      being able to meet the ethical requirements that those who regard the human
      embryo as sacred have tried to impose on stem cells research in the last ten
      years. The thesis of the article is that focusing the discussion only on the
      sources of stem cells has prevented a full understanding of the foundation,
      meaning and scope of these ethical requirements. To substantiate this thesis, the
      article takes into consideration two issues: the first has to do with the
      potential of the cells obtained through some of the new approaches (iPS
      included), the second (and decisive) with the argument of the 'indirect
      complicity', applied to the use of 'contaminated' knowledge.
FAU - Neri, Demetrio
AU  - Neri D
AD  - University of Messina - Philosophy, Italy. demetrio.neri@unime.it
LA  - eng
PT  - Journal Article
DEP - 20091130
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Embryo Research/ethics
MH  - Ethical Analysis
MH  - Humans
MH  - *Induced Pluripotent Stem Cells
MH  - Stem Cell Research/*ethics
EDAT- 2009/12/17 06:00
MHDA- 2011/09/29 06:00
CRDT- 2009/12/17 06:00
PHST- 2009/12/17 06:00 [entrez]
PHST- 2009/12/17 06:00 [pubmed]
PHST- 2011/09/29 06:00 [medline]
AID - BIOT1784 [pii]
AID - 10.1111/j.1467-8519.2009.01784.x [doi]
PST - ppublish
SO  - Bioethics. 2011 Jun;25(5):260-6. doi: 10.1111/j.1467-8519.2009.01784.x. Epub 2009
      Nov 30.


PMID- 19962261
OWN - NLM
STAT- MEDLINE
DCOM- 20110805
LR  - 20191210
IS  - 1872-7727 (Electronic)
IS  - 0720-048X (Linking)
VI  - 77
IP  - 3
DP  - 2011 Mar
TI  - Clinical validation of a software for quantitative follow-up of abdominal aortic 
      aneurysm maximal diameter and growth by CT angiography.
PG  - 502-8
LID - 10.1016/j.ejrad.2009.07.027 [doi]
AB  - PURPOSE: To compare the reproducibility and accuracy of abdominal aortic aneurysm
      (AAA) maximal diameter (D-max) measurements using segmentation software, with
      manual measurement on double-oblique MPR as a reference standard. MATERIALS AND
      METHODS: The local Ethics Committee approved this study and waived informed
      consent. Forty patients (33 men, 7 women; mean age, 72 years, range, 49-86 years)
      had previously undergone two CT angiography (CTA) studies within 16 +/- 8 months 
      for follow-up of AAA >/= 35 mm without previous treatment. The 80 studies were
      segmented twice using the software to calculate reproducibility of automatic
      D-max calculation on 3D models. Three radiologists reviewed the 80 studies and
      manually measured D-max on double-oblique MPR projections. Intra-observer and
      inter-observer reproducibility were calculated by intraclass correlation
      coefficient (ICC). Systematic errors were evaluated by linear regression and
      Bland-Altman analyses. Differences in D-max growth were analyzed with a paired
      Student's t-test. RESULTS: The ICC for intra-observer reproducibility of D-max
      measurement was 0.992 (>/= 0.987) for the software and 0.985 (>/= 0.974) and
      0.969 (>/= 0.948) for two radiologists. Inter-observer reproducibility was 0.979 
      (0.954-0.984) for the three radiologists. Mean absolute difference between
      semi-automated and manual D-max measurements was estimated at 1.1 +/- 0.9 mm and 
      never exceeded 5mm. CONCLUSION: Semi-automated software measurement of AAA D-max 
      is reproducible, accurate, and requires minimal operator intervention.
CI  - Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
FAU - Kauffmann, Claude
AU  - Kauffmann C
AD  - Department of Medical Imaging, Hopital Notre-Dame, Centre Hospitalier
      Universitaire de Montreal, 1560 Sherbrooke Est, Montreal, Quebec, Canada H2L 4M1.
      claude.kauffmann@gmail.com
FAU - Tang, An
AU  - Tang A
FAU - Dugas, Alexandre
AU  - Dugas A
FAU - Therasse, Eric
AU  - Therasse E
FAU - Oliva, Vincent
AU  - Oliva V
FAU - Soulez, Gilles
AU  - Soulez G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20091203
PL  - Ireland
TA  - Eur J Radiol
JT  - European journal of radiology
JID - 8106411
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Algorithms
MH  - Angiography/*methods
MH  - Aortic Aneurysm, Abdominal/*diagnostic imaging
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Radiographic Image Interpretation, Computer-Assisted/*methods
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - *Software
MH  - Software Validation
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2009/12/08 06:00
MHDA- 2011/08/06 06:00
CRDT- 2009/12/08 06:00
PHST- 2009/05/11 00:00 [received]
PHST- 2009/07/21 00:00 [revised]
PHST- 2009/07/22 00:00 [accepted]
PHST- 2009/12/08 06:00 [entrez]
PHST- 2009/12/08 06:00 [pubmed]
PHST- 2011/08/06 06:00 [medline]
AID - S0720-048X(09)00446-X [pii]
AID - 10.1016/j.ejrad.2009.07.027 [doi]
PST - ppublish
SO  - Eur J Radiol. 2011 Mar;77(3):502-8. doi: 10.1016/j.ejrad.2009.07.027. Epub 2009
      Dec 3.


PMID- 19962260
OWN - NLM
STAT- MEDLINE
DCOM- 20110922
LR  - 20161125
IS  - 1872-7727 (Electronic)
IS  - 0720-048X (Linking)
VI  - 78
IP  - 1
DP  - 2011 Apr
TI  - Comparison of visual scoring and quantitative planimetry methods for estimation
      of global infarct size on delayed enhanced cardiac MRI and validation with
      myocardial enzymes.
PG  - 87-92
LID - 10.1016/j.ejrad.2009.09.027 [doi]
AB  - PURPOSE: Although delayed enhanced CMR has become a reference method for infarct 
      size quantification, there is no ideal method to quantify total infarct size in a
      routine clinical practice. In a prospective study we compared the performance and
      post-processing time of a global visual scoring method to standard quantitative
      planimetry and we compared both methods to the peak values of myocardial
      biomarkers. MATERIALS AND METHODS: This study had local ethics committee
      approval; all patients gave written informed consent. One hundred and three
      patients admitted with reperfused AMI to our intensive care unit had a complete
      CMR study with gadolinium-contrast injection 4+/-2 days after admission. A global
      visual score was defined on a 17-segment model and compared with the quantitative
      planimetric evaluation of hyperenhancement. The peak values of serum Troponin I
      (TnI) and creatine kinase (CK) release were measured in each patient. RESULTS:
      The mean percentage of total left ventricular myocardium with hyperenhancement
      determined by the quantitative planimetry method was (20.1+/-14.6) with a range
      of 1-68%. There was an excellent correlation between quantitative planimetry and 
      visual global scoring for the hyperenhancement extent's measurement (r=0.94;
      y=1.093x+0.87; SEE=1.2; P<0.001) The Bland-Altman plot showed a good concordance 
      between the two approaches (mean of the differences=1.9% with a standard
      deviation of 4.7). Mean post-processing time for quantitative planimetry was
      significantly longer than visual scoring post-processing time (23.7+/-5.7min vs
      5.0+/-1.1min respectively, P<0.001). Correlation between peak CK and quantitative
      planimetry was r=0.82 (P<0.001) and r=0.83 (P<0.001) with visual global scoring. 
      Correlation between peak Troponin I and quantitative planimetry was r=0.86
      (P<0.001) and r=0.85 (P<0.001) with visual global scoring. CONCLUSION: A visual
      approach based on a 17-segment model allows a rapid and accurate assessment of
      the myocardial global delayed enhancement. This scoring method could be used on a
      daily practice and useful for the management strategy of post-MI patients.
CI  - Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
FAU - Mewton, Nathan
AU  - Mewton N
AD  - Hopital Cardiovasculaire Louis Pradel, 28, Avenue Doyen Lepine, 69677 Bron cedex,
      Hospices Civils de Lyon, France. nmewton@gmail.com
FAU - Revel, Didier
AU  - Revel D
FAU - Bonnefoy, Eric
AU  - Bonnefoy E
FAU - Ovize, Michel
AU  - Ovize M
FAU - Croisille, Pierre
AU  - Croisille P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091203
PL  - Ireland
TA  - Eur J Radiol
JT  - European journal of radiology
JID - 8106411
RN  - 0 (Biomarkers)
RN  - 0 (Contrast Media)
RN  - 0 (Heterocyclic Compounds)
RN  - 0 (Organometallic Compounds)
RN  - 0 (Troponin I)
RN  - 99J2XUF1JT (gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate)
RN  - EC 2.7.3.2 (Creatine Kinase)
SB  - IM
MH  - Biomarkers/blood
MH  - Contrast Media
MH  - Creatine Kinase/blood
MH  - Female
MH  - Heterocyclic Compounds
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Imaging, Three-Dimensional
MH  - Linear Models
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/blood/*pathology
MH  - Observer Variation
MH  - Organometallic Compounds
MH  - Prospective Studies
MH  - Troponin I/blood
EDAT- 2009/12/08 06:00
MHDA- 2011/09/23 06:00
CRDT- 2009/12/08 06:00
PHST- 2009/07/08 00:00 [received]
PHST- 2009/09/25 00:00 [accepted]
PHST- 2009/12/08 06:00 [entrez]
PHST- 2009/12/08 06:00 [pubmed]
PHST- 2011/09/23 06:00 [medline]
AID - S0720-048X(09)00546-4 [pii]
AID - 10.1016/j.ejrad.2009.09.027 [doi]
PST - ppublish
SO  - Eur J Radiol. 2011 Apr;78(1):87-92. doi: 10.1016/j.ejrad.2009.09.027. Epub 2009
      Dec 3.


PMID- 19961514
OWN - NLM
STAT- MEDLINE
DCOM- 20110531
LR  - 20110317
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 11
IP  - 1
DP  - 2011 Apr
TI  - New directions in African bioethics: ways of including public health concerns in 
      the bioethics agenda.
PG  - 4-15
LID - 10.1111/j.1471-8847.2009.00271.x [doi]
AB  - Research ethics is the most developed aspect of bioethics in Africa. Most African
      countries have set up Institutional Review Boards (IRBs) to provide guidelines
      for research and to comply with international norms. However, bioethics has not
      been responsive to local needs and values in the rest of the continent. A new
      direction is needed in African bioethics. This new direction promotes the
      development of a locally-grounded bioethics, shaped by a dynamic understanding of
      local cultures and informed by structural and institutional problems that impact 
      the public's health, as well as cognisant of the salient contribution of social
      sciences and social epidemiology which can bring a lasting impact on African
      local communities. In today's post-Structural Adjustment Africa, where healthcare
      has been liberalized and its cost increased, a bioethics agenda that focuses
      essentially on disease management and clinical work remains blind in the face of 
      a structural marginalization of the masses of poor. Instead, the multidimensional
      public health crisis, with which most African countries are confronted, calls for
      a bioethics agenda that focuses primarily, but not exclusively, on health
      promotion and advocacy. Such an approach to bioethics reckons with the
      macro-determinants of health and well-being and places clinical and research
      ethics in the broader context of population's health. The same approach
      underscores the need to become political, not only by addressing health
      policymaking processes and procedures, but also by becoming an advocacy forum
      that includes other constituencies equipped with the potentialities to impact the
      population's health.
CI  - (c) 2009 Blackwell Publishing Ltd.
FAU - Azetsop, Jacquineau
AU  - Azetsop J
AD  - Faculte de medicine Teilhard de Chardin, N'djamena, Chad. maishaze@yahoo.com
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
SB  - IM
MH  - Africa
MH  - Bioethics/*trends
MH  - Cultural Characteristics
MH  - Epidemiology
MH  - Ethics Committees, Research
MH  - *Ethics, Clinical
MH  - *Ethics, Research
MH  - Health Promotion/*ethics/trends
MH  - Humans
MH  - *Politics
MH  - Principle-Based Ethics
MH  - Public Health/*ethics/standards/trends
MH  - *Public Policy/trends
MH  - Research Support as Topic
MH  - Social Sciences
EDAT- 2009/12/08 06:00
MHDA- 2011/06/01 06:00
CRDT- 2009/12/08 06:00
PHST- 2009/12/08 06:00 [entrez]
PHST- 2009/12/08 06:00 [pubmed]
PHST- 2011/06/01 06:00 [medline]
AID - DEWB271 [pii]
AID - 10.1111/j.1471-8847.2009.00271.x [doi]
PST - ppublish
SO  - Dev World Bioeth. 2011 Apr;11(1):4-15. doi: 10.1111/j.1471-8847.2009.00271.x.


PMID- 19954912
OWN - NLM
STAT- MEDLINE
DCOM- 20111102
LR  - 20110601
IS  - 1872-7727 (Electronic)
IS  - 0720-048X (Linking)
VI  - 78
IP  - 3
DP  - 2011 Jun
TI  - Magnetic resonance imaging features of asymptomatic bipartite patella.
PG  - 425-9
LID - 10.1016/j.ejrad.2009.11.001 [doi]
AB  - OBJECTIVE: The purpose of our study was to describe the magnetic resonance
      imaging (MRI) features of bipartite patella in asymptomatic patients. MATERIALS
      AND METHODS: The study was prospective in type and performed following
      institutional ethical committees approval. In total, 25 subjects were recruited
      into the study and informed consent obtained in each case. The local radiology
      database was utilised in conjunction with a clinical questionnaire to identify
      patients who had asymptomatic bipartite patella. Any patient with a history of
      trauma or symptomatic disease was excluded from the study. MRI imaging was
      performed in each case on a 1.5 T system using a dedicated knee coil and a
      standardised knee protocol. The images obtained were then analysed by two
      musculoskeletal radiologists in consensus. RESULTS: Of the 25 subjects, there
      were 8 females and 17 males. The mean age was 34.6 years. All but one of the
      bipartite fragments were located on the superolateral aspect of the patella. In
      23 cases, one fragment was identified. The average transverse diameter of the
      fragment was 12.8 mm. The average distance between the fragment and the adjacent 
      patella in the axial plane was 1.46 mm. In addition, the cartilage overlying the 
      patella and accessory fragment was intact in all cases. The average thickness of 
      the patella cartilage at its border to the fragment was 2.4mm with an average
      ratio of the cartilage thickness of the fragment as compared with the cartilage
      thickness of the patella of 0.72. There was no evidence of high signal or bone
      marrow oedema on fluid sensitive sequences within either the patella or the
      fragment in any of the patients. Fluid was identified in the cleft between the
      patella and the fragment in the majority of cases. CONCLUSIONS: Asymptomatic
      bipartite patella is characterised by intact but thinned cartilage along the
      border between the patella and the fragment, fluid between the cleft and a lack
      of any bone marrow oedema or high signal within the patella or its fragment.
CI  - Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
FAU - O'Brien, J
AU  - O'Brien J
AD  - Department of Radiology, Adelaide and Meath Incorporating National Children's
      Hospital, Tallaght, Dublin 24, Ireland. juliemobrien@gmail.com
FAU - Murphy, C
AU  - Murphy C
FAU - Halpenny, D
AU  - Halpenny D
FAU - McNeill, G
AU  - McNeill G
FAU - Torreggiani, W C
AU  - Torreggiani WC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091201
PL  - Ireland
TA  - Eur J Radiol
JT  - European journal of radiology
JID - 8106411
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cartilage, Articular/*abnormalities/*pathology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Patella/*abnormalities/*pathology
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
EDAT- 2009/12/04 06:00
MHDA- 2011/11/04 06:00
CRDT- 2009/12/04 06:00
PHST- 2009/10/12 00:00 [received]
PHST- 2009/11/04 00:00 [accepted]
PHST- 2009/12/04 06:00 [entrez]
PHST- 2009/12/04 06:00 [pubmed]
PHST- 2011/11/04 06:00 [medline]
AID - S0720-048X(09)00627-5 [pii]
AID - 10.1016/j.ejrad.2009.11.001 [doi]
PST - ppublish
SO  - Eur J Radiol. 2011 Jun;78(3):425-9. doi: 10.1016/j.ejrad.2009.11.001. Epub 2009
      Dec 1.


PMID- 19948532
OWN - NLM
STAT- MEDLINE
DCOM- 20120530
LR  - 20151119
IS  - 1470-2738 (Electronic)
IS  - 0143-005X (Linking)
VI  - 65
IP  - 2
DP  - 2011 Feb
TI  - Public good, personal privacy: a citizens' deliberation about using medical
      information for pharmacoepidemiological research.
PG  - 150-6
LID - 10.1136/jech.2009.097436 [doi]
AB  - BACKGROUND: Epidemiologists have long argued for access to personal medical
      information in order to undertake research in the public interest, while
      legislation and ethical guidelines have increasingly focused on protecting the
      privacy of individuals. How the public weighs up these public interest and
      privacy arguments is unclear. METHODS: A citizens' jury was held to explore
      public views about the use of medical information for the post-marketing
      surveillance of medicine safety. A steering group of stakeholders oversaw the
      process, including the framing of the question for the jury and the selection of 
      expert witnesses and jurors. An independent chair and facilitator managed the
      3-day hearing. RESULTS: The jury unanimously concluded that researchers
      contracted by a public body should be permitted to use medical information about 
      identifiable people, without their consent, to study the safety of
      medicines--providing existing ethical guidelines and relevant laws are followed. 
      Jurors who were initially uncomfortable about the use of information without
      their express consent all became more comfortable after obtaining further
      information and deliberating with other jurors. CONCLUSIONS: This outcome
      suggests that an informed public does not place personal privacy above societal
      benefits in the particular circumstance of medicines' safety research, given
      appropriate privacy safeguards. The specificity of the example, the framing of
      the public interest and privacy considerations--in the context of scientific,
      legal, ethical, clinical and consumer input--and the opportunity to deliberate,
      may explain why the conclusions of the jury differ from public opinion surveys
      about secondary uses of medical information.
FAU - Parkin, Lianne
AU  - Parkin L
AD  - Department of Preventive and Social Medicine, University of Otago, Dunedin, New
      Zealand. lianne.parkin@otago.ac.nz
FAU - Paul, Charlotte
AU  - Paul C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091129
PL  - England
TA  - J Epidemiol Community Health
JT  - Journal of epidemiology and community health
JID - 7909766
SB  - IM
MH  - Access to Information/*ethics/legislation & jurisprudence
MH  - Biomedical Research/ethics/*standards
MH  - Community-Institutional Relations
MH  - Disclosure/ethics
MH  - Drug-Related Side Effects and Adverse Reactions
MH  - Duty to Recontact
MH  - Expert Testimony
MH  - Group Processes
MH  - Guidelines as Topic
MH  - Humans
MH  - Information Dissemination/ethics/legislation & jurisprudence
MH  - Informed Consent
MH  - *Judicial Role
MH  - *Medical Records
MH  - New Zealand
MH  - Personal Autonomy
MH  - Pharmacoepidemiology/*ethics
MH  - *Privacy/legislation & jurisprudence/psychology
MH  - Product Surveillance, Postmarketing
MH  - *Public Opinion
MH  - Research Subjects
MH  - Surveys and Questionnaires
EDAT- 2009/12/02 06:00
MHDA- 2012/05/31 06:00
CRDT- 2009/12/02 06:00
PHST- 2009/12/02 06:00 [entrez]
PHST- 2009/12/02 06:00 [pubmed]
PHST- 2012/05/31 06:00 [medline]
AID - jech.2009.097436 [pii]
AID - 10.1136/jech.2009.097436 [doi]
PST - ppublish
SO  - J Epidemiol Community Health. 2011 Feb;65(2):150-6. doi:
      10.1136/jech.2009.097436. Epub 2009 Nov 29.


PMID- 19941087
OWN - NLM
STAT- MEDLINE
DCOM- 20110922
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 17
IP  - 1
DP  - 2011 Mar
TI  - Do we need a special ethics for research?
PG  - 21-9
LID - 10.1007/s11948-009-9186-6 [doi]
AB  - Research is subject to more stringent ethical requirements than most other human 
      activities, and a procedure that is otherwise allowed may be forbidden in
      research. Hence, risk-taking is more restricted in scientific research than in
      most non-research contexts, and privacy is better protected in scientific
      questionnaires than in marketing surveys. Potential arguments for this difference
      are scrutinized. The case in its favour appears to be weak. A stronger case can
      be made in favour of a difference in the opposite direction: If perilous or
      otherwise problematic activities have to be performed it is usually better to
      perform them in a research context where they are properly evaluated so that
      guidance is obtained for the future. However, retreating from current ethical
      demands on research is not a desirable direction to go. Instead, research ethics 
      can serve to inspire the introduction of more stringent ethical principles in
      other social sectors.
FAU - Hansson, Sven Ove
AU  - Hansson SO
AD  - Department of Philosophy and the History of Technology, Royal Institute of
      Technology, Teknikringen 78, 100 44, Stockholm, Sweden. soh@kth.se
LA  - eng
PT  - Journal Article
DEP - 20091126
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Data Collection/ethics
MH  - *Ethics, Business
MH  - *Ethics, Research
MH  - Humans
MH  - Marketing/ethics
MH  - Privacy
MH  - Risk-Taking
MH  - Science/*ethics
MH  - Surveys and Questionnaires
EDAT- 2009/11/27 06:00
MHDA- 2011/09/23 06:00
CRDT- 2009/11/27 06:00
PHST- 2009/08/10 00:00 [received]
PHST- 2009/11/10 00:00 [accepted]
PHST- 2009/11/27 06:00 [entrez]
PHST- 2009/11/27 06:00 [pubmed]
PHST- 2011/09/23 06:00 [medline]
AID - 10.1007/s11948-009-9186-6 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2011 Mar;17(1):21-9. doi: 10.1007/s11948-009-9186-6. Epub 2009
      Nov 26.


PMID- 19937149
OWN - NLM
STAT- MEDLINE
DCOM- 20110922
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 17
IP  - 1
DP  - 2011 Mar
TI  - Dissolving the engineering moral dilemmas within the Islamic ethico-legal praxes.
PG  - 133-47
LID - 10.1007/s11948-009-9185-7 [doi]
AB  - The goal of responsible engineers is the creation of useful and safe
      technological products and commitment to public health, while respecting the
      autonomy of the clients and the public. Because engineers often face moral
      dilemma to resolve such issues, different engineers have chosen different course 
      of actions depending on their respective moral value orientations. Islam provides
      a value-based mechanism rooted in the Maqasid al-Shari'ah (the objectives of
      Islamic law). This mechanism prioritizes some values over others and could help
      resolve the moral dilemmas faced in engineering. This paper introduces the
      Islamic interpretive-evaluative maxims to two core issues in engineering ethics: 
      genetically modified foods and whistleblowing. The study aims primarily to
      provide problem-solving maxims within the Maqasid al-Shari'ah matrix through
      which such moral dilemmas in science and engineering could be studied and
      resolved.
FAU - Solihu, Abdul Kabir Hussain
AU  - Solihu AK
AD  - Department of General Studies, Faculty of Islamic Revealed Knowledge and Human
      Sciences, International Islamic University Malaysia, P.O. Box 10, 50728, Kuala
      Lumpur, Malaysia. kabir@iiu.edu.my
FAU - Ambali, Abdul Rauf
AU  - Ambali AR
LA  - eng
PT  - Journal Article
DEP - 20091124
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Engineering/*ethics
MH  - *Food, Genetically Modified
MH  - Genetic Engineering/ethics
MH  - Humans
MH  - *Islam
MH  - *Morals
MH  - Public Health/ethics
MH  - *Religion and Science
MH  - Social Responsibility
MH  - *Social Values
MH  - Whistleblowing/*ethics
EDAT- 2009/11/26 06:00
MHDA- 2011/09/23 06:00
CRDT- 2009/11/26 06:00
PHST- 2009/01/15 00:00 [received]
PHST- 2009/11/09 00:00 [accepted]
PHST- 2009/11/26 06:00 [entrez]
PHST- 2009/11/26 06:00 [pubmed]
PHST- 2011/09/23 06:00 [medline]
AID - 10.1007/s11948-009-9185-7 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2011 Mar;17(1):133-47. doi: 10.1007/s11948-009-9185-7. Epub 2009 
      Nov 24.


PMID- 19936967
OWN - NLM
STAT- MEDLINE
DCOM- 20110922
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 17
IP  - 1
DP  - 2011 Mar
TI  - Parallel, embedded or just part of the team: ethicists cooperating within a
      European security research project.
PG  - 31-43
LID - 10.1007/s11948-009-9187-5 [doi]
AB  - Different methods have been developed to address ethical issues during research. 
      Most of these methods were developed at universities. In this article ethical
      parallel research within a Research and Technology Organization is described.
      Within a European project about perceived security, CPSI, the ethical issues were
      identified by ethicists cooperating in the project. The project CPSI was aimed at
      developing a research method that can be used by (local) government to monitor or
      assess perceived and actual security. Together with the researchers a way was
      sought to address the ethical issues. Several issues could be addressed by
      choices with regard to the design of the validation study, in this case a survey.
      The ethical and legal reasons that were relevant for choices in the design of the
      validation study were made an integral part of these decisions. Some issues were 
      already identified during the writing of the proposal others were only identified
      during the research. Participating in the research gave the ethicists access to
      all relevant information. It made it possible to address the ethical issues when 
      they became relevant. Ethical reasons were part of some of the discussions on
      research method. It proved possible to address most ethical issues satisfactorily
      during the research project.
FAU - van Gorp, A
AU  - van Gorp A
AD  - Institute for Security, College of Integral Security Studies, Hogeschool Utrecht,
      Utrecht, The Netherlands. Anke.vangorp@hu.nl
FAU - van der Molen, S
AU  - van der Molen S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091120
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Cooperative Behavior
MH  - Data Collection
MH  - Decision Making/*ethics
MH  - *Ethicists
MH  - *Ethics
MH  - *Ethics, Research
MH  - Europe
MH  - Local Government
MH  - *Research Design
MH  - *Security Measures
MH  - Validation Studies as Topic
EDAT- 2009/11/26 06:00
MHDA- 2011/09/23 06:00
CRDT- 2009/11/26 06:00
PHST- 2009/08/31 00:00 [received]
PHST- 2009/11/10 00:00 [accepted]
PHST- 2009/11/26 06:00 [entrez]
PHST- 2009/11/26 06:00 [pubmed]
PHST- 2011/09/23 06:00 [medline]
AID - 10.1007/s11948-009-9187-5 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2011 Mar;17(1):31-43. doi: 10.1007/s11948-009-9187-5. Epub 2009
      Nov 20.


PMID- 19925567
OWN - NLM
STAT- MEDLINE
DCOM- 20110725
LR  - 20131121
IS  - 1439-0507 (Electronic)
IS  - 0933-7407 (Linking)
VI  - 54
IP  - 3
DP  - 2011 May
TI  - Efficacy and tolerability of sertaconazole nitrate 2% cream vs. miconazole in
      patients with cutaneous dermatophytosis.
PG  - 217-22
LID - 10.1111/j.1439-0507.2009.01801.x [doi]
AB  - Sertaconazole is a new antifungal agent. To compare the efficacy and tolerability
      of sertaconazole and miconazole cream in cutaneous dermatophytosis, this
      prospective, randomized, multicentric comparative, phase 4 study was undertaken
      in 260 patients with cutaneous dermatophytosis after approvals from Institutional
      Ethics Committees. Patients were assigned to sertaconazole cream (2%) or
      miconazole cream (2%) topically twice daily for 2 weeks after obtaining informed 
      consent. Efficacy variables included changes in mean scores of erythema,
      pruritus, desquamation, erythema/itching, burning/weeping, scaling/pustule and
      overall global assessment. Safety and tolerability were also assessed. A total of
      122 patients in the sertaconazole group and 128 in the miconazole group completed
      the study with 10 drop-outs. There was a significant decrease (P < 0.05) in mean 
      symptom scores and total scores from the first week onwards, sustained till 2
      weeks and statistically significant (P < 0.05) in favour of sertaconazole.
      Moreover, 62.3% patients had complete clinical cure in the sertaconazole group (P
      < 0.05) compared with 44.6% in miconazole users. Both drugs were well tolerated
      and five patients in the sertaconazole group and nine in the miconazole group
      reported mild to moderate adverse events. Therapy with sertaconazole cream (2%)
      provided a better efficacy and tolerability compared with the miconazole cream
      (2%) and could thus be a therapeutic option in cutaneous dermatophytosis.
CI  - (c) 2009 Blackwell Verlag GmbH.
FAU - Sharma, A
AU  - Sharma A
AD  - Medical Services, Glenmark Pharmaceuticals Ltd, Mumbai, India.
FAU - Saple, D G
AU  - Saple DG
FAU - Surjushe, A
AU  - Surjushe A
FAU - Rao, G R R
AU  - Rao GR
FAU - Kura, M
AU  - Kura M
FAU - Ghosh, S
AU  - Ghosh S
FAU - Bolmall, C
AU  - Bolmall C
FAU - Baliga, V
AU  - Baliga V
LA  - eng
PT  - Clinical Trial, Phase IV
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PL  - Germany
TA  - Mycoses
JT  - Mycoses
JID - 8805008
RN  - 0 (Antifungal Agents)
RN  - 0 (Imidazoles)
RN  - 0 (Thiophenes)
RN  - 72W71I16EG (sertaconazole)
RN  - 7NNO0D7S5M (Miconazole)
SB  - IM
MH  - Administration, Topical
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Antifungal Agents/*administration & dosage/adverse effects
MH  - Dermatomycoses/*drug therapy/pathology
MH  - Female
MH  - Humans
MH  - Imidazoles/*administration & dosage/adverse effects
MH  - Male
MH  - Miconazole/*administration & dosage/adverse effects
MH  - Middle Aged
MH  - Prospective Studies
MH  - Thiophenes/*administration & dosage/adverse effects
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2009/11/21 06:00
MHDA- 2011/07/26 06:00
CRDT- 2009/11/21 06:00
PHST- 2009/11/21 06:00 [entrez]
PHST- 2009/11/21 06:00 [pubmed]
PHST- 2011/07/26 06:00 [medline]
AID - MYC1801 [pii]
AID - 10.1111/j.1439-0507.2009.01801.x [doi]
PST - ppublish
SO  - Mycoses. 2011 May;54(3):217-22. doi: 10.1111/j.1439-0507.2009.01801.x.


PMID- 19915957
OWN - NLM
STAT- MEDLINE
DCOM- 20110922
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 17
IP  - 1
DP  - 2011 Mar
TI  - Professional virtue and professional self-awareness: a case study in engineering 
      ethics.
PG  - 109-32
LID - 10.1007/s11948-009-9182-x [doi]
AB  - This paper articulates an Aristotelian theory of professional virtue and provides
      an application of that theory to the subject of engineering ethics. The leading
      idea is that Aristotle's analysis of the definitive function of human beings, and
      of the virtues humans require to fulfill that function, can serve as a model for 
      an analysis of the definitive function or social role of a profession and thus of
      the virtues professionals must exhibit to fulfill that role. Special attention is
      given to a virtue of professional self-awareness, an analogue to Aristotle's
      phronesis or practical wisdom. In the course of laying out my account I argue
      that the virtuous professional is the successful professional, just as the
      virtuous life is the happy life for Aristotle. I close by suggesting that a
      virtue ethics approach toward professional ethics can enrich the pedagogy of
      professional ethics courses and help foster a sense of pride and responsibility
      in young professionals.
FAU - Stovall, Preston
AU  - Stovall P
AD  - pjs44@pitt.edu
LA  - eng
PT  - Journal Article
DEP - 20091114
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Engineering/*ethics
MH  - *Ethical Theory
MH  - *Ethics, Professional
MH  - Humans
MH  - *Professional Competence
MH  - *Self Concept
MH  - *Social Responsibility
MH  - Social Values
MH  - *Virtues
EDAT- 2009/11/17 06:00
MHDA- 2011/09/23 06:00
CRDT- 2009/11/17 06:00
PHST- 2009/08/29 00:00 [received]
PHST- 2009/10/21 00:00 [accepted]
PHST- 2009/11/17 06:00 [entrez]
PHST- 2009/11/17 06:00 [pubmed]
PHST- 2011/09/23 06:00 [medline]
AID - 10.1007/s11948-009-9182-x [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2011 Mar;17(1):109-32. doi: 10.1007/s11948-009-9182-x. Epub 2009 
      Nov 14.


PMID- 19896789
OWN - NLM
STAT- MEDLINE
DCOM- 20110805
LR  - 20110315
IS  - 1872-7727 (Electronic)
IS  - 0720-048X (Linking)
VI  - 77
IP  - 3
DP  - 2011 Mar
TI  - MRI for the size assessment of pure ductal carcinoma in situ (DCIS): a
      prospective study of 33 patients.
PG  - 462-7
LID - 10.1016/j.ejrad.2009.09.003 [doi]
AB  - OBJECTIVE: To determine whether MRI assesses the size of ductal carcinomas in
      situ (DCIS) more accurately than mammography, using the histopathological
      dimension of the surgical specimen as the reference measurement. MATERIALS AND
      METHODS: This single-center prospective study conducted from March 2007 to July
      2008 at the Antoine-Lacassagne Cancer Treatment Center (Nice, France) included 33
      patients with a histologically proven DCIS by needle biopsy, who all underwent
      clinical examination, mammography, and MRI interpreted by an experienced
      radiologist. All patients underwent surgery at our institution. The greatest
      dimensions of the DCIS determined by the two imaging modalities were compared
      with the histopathological dimension ascertained on the surgical specimen. The
      study was approved by the local Ethical Research Committee and was authorized by 
      the French National Health Agency (AFSSAPS). RESULTS: The mean age of the 33
      patients was 59.7 years (+/- 10.3). Three patients had a palpable mass at
      clinical breast examination; 82% underwent conservative surgical therapy rather
      than radical breast surgery (mastectomy); 6% required repeat surgery. MRI
      detected 97% of the lesions. Non-mass-like enhancement was noted for 78% of the
      patients. In over 50% of the cases, distribution of the DCIS was ductal or
      segmental and the kinetic enhancement curve was persistent. Lesion size was
      correctly estimated (+/- 5 mm), under-estimated (<5mm), or over-estimated (>5mm),
      respectively, by MRI in 60%, 19% and 21% of cases and by mammography in 38%, 31% 
      and 31% (p = 0.05). Mean lesion size was 25.6mm at histopathology, 28.1mm at MRI,
      and 27.2mm on mammography (nonsignificant difference). The correlation
      coefficient between histopathological measurement and MRI was 0.831 versus 0.674 
      between histopathology and mammography. The correlation coefficient increased
      with the nuclear grade of the DCIS on mammography; this coefficient also
      increased as the mammographic breast density decreased. CONCLUSION: MRI appears
      to assess the size of DCIS better than mammography by limiting the number of
      under- and over-estimations compared to histopathology findings.
CI  - Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
FAU - Marcotte-Bloch, C
AU  - Marcotte-Bloch C
AD  - Department of Medical Imaging, Centre Antoine Lacassagne, 33 route de Valombrose,
      06100 Nice, France. marcotte.c@free.fr
FAU - Balu-Maestro, C
AU  - Balu-Maestro C
FAU - Chamorey, E
AU  - Chamorey E
FAU - Ettore, F
AU  - Ettore F
FAU - Raoust, I
AU  - Raoust I
FAU - Flipo, B
AU  - Flipo B
FAU - Chapellier, C
AU  - Chapellier C
LA  - eng
PT  - Journal Article
DEP - 20091106
PL  - Ireland
TA  - Eur J Radiol
JT  - European journal of radiology
JID - 8106411
SB  - IM
MH  - Breast Neoplasms/*pathology
MH  - Carcinoma, Intraductal, Noninfiltrating/*pathology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Middle Aged
MH  - Prospective Studies
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
EDAT- 2009/11/10 06:00
MHDA- 2011/08/06 06:00
CRDT- 2009/11/10 06:00
PHST- 2009/05/28 00:00 [received]
PHST- 2009/09/03 00:00 [accepted]
PHST- 2009/11/10 06:00 [entrez]
PHST- 2009/11/10 06:00 [pubmed]
PHST- 2011/08/06 06:00 [medline]
AID - S0720-048X(09)00522-1 [pii]
AID - 10.1016/j.ejrad.2009.09.003 [doi]
PST - ppublish
SO  - Eur J Radiol. 2011 Mar;77(3):462-7. doi: 10.1016/j.ejrad.2009.09.003. Epub 2009
      Nov 6.


PMID- 19888951
OWN - NLM
STAT- MEDLINE
DCOM- 20110518
LR  - 20140730
IS  - 1463-1318 (Electronic)
IS  - 1462-8910 (Linking)
VI  - 13
IP  - 2
DP  - 2011 Feb
TI  - Stapled haemorrhoidopexy transiently decreases rectal compliance and sensitivity.
PG  - 219-24
LID - 10.1111/j.1463-1318.2009.02103.x [doi]
AB  - AIM: Stapled haemorrhoidopexy may damage the anorectal musculature and its
      sensorimotor function. Most studies have not used a barostat for the measurement 
      of compliance. This study aimed to investigate the effect of stapled
      haemorrhoidopexy on rectal compliance and sensitivity. METHOD: After Ethical
      Committee approval, we studied 10 male patients (mean age 33.8 years) with third-
      or fourth-degree haemorrhoids. Rectal compliance and sensitivity were measured
      with a 600-ml bag and an electronic barostat. Volunteers were submitted to two
      consecutive rectal distension protocols, including continuous distension at 2, 4 
      and 6 months after stapled haemorrhoidopexy. Intraluminal volume and pressure
      were recorded, including the first rectal sensation, desire to defecate and onset
      of rectal pain. Another group of 10 male control patients (mean age 24.9 years)
      with pilonidal sinus and no haemorrhoids was also included in the study. RESULTS:
      Two months after stapled haemorrhoidopexy, rectal compliance decreased (7.1 +/-
      0.2 vs 5.3 +/- 0.1, 6.4 +/- 0.1 vs 5.1 +/- 0.1 and 5.6 +/- 0.2 vs 4.7 +/- 0.1
      ml/mmHg for first rectal sensation, desire to defecate and rectal pain,
      respectively; P < 0.05). The sensitivity threshold volume did not change for the 
      first sensation but decreased significantly for the desier to defecate and pain
      (p <0.05) (116.8 +/- 13.8 vs 148.4 +/- 14.61, 251.1 +/- 8.9 vs 185.8 +/- 8.6 and 
      293.3 +/- 16.6 vs 221.2 +/- 6.0 ml for first rectal sensation, desire to defecate
      and rectal pain, respectively). Four and 6 months after surgery, rectal
      compliance and sensitivity returned to levels similar to those in the basal
      period. Muscle tissue was found in only three of the 10 resected doughnuts.
      Controls remained without any change in rectal compliance and sensitivity.
      CONCLUSION: Stapled haemorrhoidopexy transiently decreases rectal compliance and 
      sensitivity threshold in young male patients.
CI  - (c) 2010 The Authors. Colorectal Disease (c) 2010 The Association of
      Coloproctology of Great Britain and Ireland.
FAU - Filho, F L A
AU  - Filho FL
AD  - Departments of Surgery Physiology and Pharmacology and Clinical Medicine, School 
      of Medicine, Federal University of Ceara, Fortaleza, Brazil.
FAU - Macedo, G M
AU  - Macedo GM
FAU - Dos Santos, A A
AU  - Dos Santos AA
FAU - Rodrigues, L V
AU  - Rodrigues LV
FAU - Oliveira, R B
AU  - Oliveira RB
FAU - Nobre E Souza, M A
AU  - Nobre E Souza MA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Colorectal Dis
JT  - Colorectal disease : the official journal of the Association of Coloproctology of
      Great Britain and Ireland
JID - 100883611
SB  - IM
MH  - Adult
MH  - Compliance
MH  - Hemorrhoids/*surgery
MH  - Humans
MH  - Male
MH  - Postoperative Complications/physiopathology
MH  - Rectum/innervation/*physiopathology
MH  - Sensory Thresholds
MH  - *Surgical Stapling
EDAT- 2009/11/06 06:00
MHDA- 2011/05/19 06:00
CRDT- 2009/11/06 06:00
PHST- 2009/11/06 06:00 [entrez]
PHST- 2009/11/06 06:00 [pubmed]
PHST- 2011/05/19 06:00 [medline]
AID - CDI2103 [pii]
AID - 10.1111/j.1463-1318.2009.02103.x [doi]
PST - ppublish
SO  - Colorectal Dis. 2011 Feb;13(2):219-24. doi: 10.1111/j.1463-1318.2009.02103.x.


PMID- 19860746
OWN - NLM
STAT- MEDLINE
DCOM- 20110823
LR  - 20110412
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 25
IP  - 4
DP  - 2011 May
TI  - Current functions of Italian ethics committees: a cross-sectional study.
PG  - 220-7
LID - 10.1111/j.1467-8519.2009.01769.x [doi]
AB  - BACKGROUND: The rapid pace of progress in medical research, the consequent need
      for the timely transfer of new knowledge into practice, and the increasing need
      for ethics support, is making the work of Ethics Committees (ECs) ever more
      complex and demanding. As a response, ECs in many countries exhibit large
      variation in number, mandate, organization and member competences. This
      cross-sectional study aims to give an overview of the different types of
      activities of Italian ECs and favour discussion at a European level. METHODS: A
      questionnaire was emailed to all Italian Ethics Committees contained in the
      national Registry of the Ministry of Health, enquiring whether the EC was
      conducting, or planning to conduct, 4 specific activities. A telephone interview 
      was conducted to determine reasons for failure to respond. RESULTS: Response rate
      was 53% (101 respondents out of 191). 20% of ECs restrict their responsibilities 
      to research protocol review, 25% also offer ethical consultation to institutions,
      support on individual health care decisions and promotes educational initiatives,
      while the remaining 50% conduct a few of the examined activities to varying
      degrees. Large variation was observed across different types of hosting
      institutions and geographical locations. CONCLUSIONS: A common European model
      should be developed, defining EC functions, member selection modalities,
      necessary member competences, decision-making criteria and measures for work
      verification. In the absence of sound empirical evidence, it would be interesting
      to study the effectiveness and efficiency of the different existing models.
CI  - (c) 2009 Blackwell Publishing Ltd.
FAU - Caminiti, Caterina
AU  - Caminiti C
AD  - Azienda Ospedaliero-Universitaria di Parma - Research and Innovation, Parma,
      Italy. ccaminiti@ao.pr.it
FAU - Diodati, Francesca
AU  - Diodati F
FAU - Gatti, Arianna
AU  - Gatti A
FAU - Santachiara, Saverio
AU  - Santachiara S
FAU - Spinsanti, Sandro
AU  - Spinsanti S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Cross-Sectional Studies
MH  - Decision Making/ethics
MH  - Ethics Committees, Research/*organization & administration
MH  - Female
MH  - Health Care Surveys
MH  - Humans
MH  - Italy
MH  - Male
MH  - *Professional Role
MH  - *Task Performance and Analysis
EDAT- 2009/10/29 06:00
MHDA- 2011/08/24 06:00
CRDT- 2009/10/29 06:00
PHST- 2009/10/29 06:00 [entrez]
PHST- 2009/10/29 06:00 [pubmed]
PHST- 2011/08/24 06:00 [medline]
AID - BIOT1769 [pii]
AID - 10.1111/j.1467-8519.2009.01769.x [doi]
PST - ppublish
SO  - Bioethics. 2011 May;25(4):220-7. doi: 10.1111/j.1467-8519.2009.01769.x.


PMID- 19821061
OWN - NLM
STAT- MEDLINE
DCOM- 20110922
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 17
IP  - 1
DP  - 2011 Mar
TI  - Understanding engineering professionalism: a reflection on the rights of
      engineers.
PG  - 149-69
LID - 10.1007/s11948-009-9166-x [doi]
AB  - Engineering societies such as the National Society of Professional Engineers
      (NSPE) and associated entities have defined engineering and professionalism in
      such a way as to require the benefit of humanity (NSPE 2009a, Engineering
      Education Resource Document. NSPE Position Statements. Governmental Relations).
      This requirement has been an unnecessary and unfortunate "add-on." The trend of
      the profession to favor the idea of requiring the benefit of humanity for
      professionalism violates an engineer's rights. It applies political pressure that
      dissuades from inquiry, approaches to new knowledge and technologies, and the
      presentation, publication, and use of designs and research findings. Moreover, a 
      more politically neutral definition of engineering and/or professionalism devoid 
      of required service or benefit to mankind does not violate adherence to strong
      ethical standards.
FAU - Stieb, James A
AU  - Stieb JA
AD  - Department of English and Philosophy, Drexel University, MacAlister Hall, Room
      5055, Philadelphia, PA, USA. stiebja@drexel.edu
LA  - eng
PT  - Journal Article
DEP - 20091010
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Engineering/*ethics
MH  - *Ethics, Professional
MH  - *Ethics, Research
MH  - *Human Rights
MH  - Humans
MH  - Politics
MH  - *Professional Competence
MH  - *Social Responsibility
EDAT- 2009/10/13 06:00
MHDA- 2011/09/23 06:00
CRDT- 2009/10/13 06:00
PHST- 2009/08/09 00:00 [received]
PHST- 2009/09/01 00:00 [accepted]
PHST- 2009/10/13 06:00 [entrez]
PHST- 2009/10/13 06:00 [pubmed]
PHST- 2011/09/23 06:00 [medline]
AID - 10.1007/s11948-009-9166-x [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2011 Mar;17(1):149-69. doi: 10.1007/s11948-009-9166-x. Epub 2009 
      Oct 10.


PMID- 19798588
OWN - NLM
STAT- MEDLINE
DCOM- 20110922
LR  - 20220316
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 17
IP  - 1
DP  - 2011 Mar
TI  - Impact of excessive journal self-citations: a case study on the Folia Phoniatrica
      et Logopaedica journal.
PG  - 65-73
LID - 10.1007/s11948-009-9177-7 [doi]
AB  - There is an increasing trend towards assessing the scientific performance of
      researchers and institutions of higher learning in the form of journal
      publications and the associated citations. Currently, the journal impact factor
      (JIF) value is the most widely used measure for any academic contents. However,
      there are growing concerns for the unethical practices adopted by journal editors
      to manipulate the JIF computations. Recently, a Swiss journal, Folia Phoniatrica 
      et Logopaedica which has a JIF value of 0.655 in the year 2006 registers a
      remarkable JIF increment (of 119%) to 1.439 in the year 2007. It is believed that
      the journal can achieve such a prominent JIF improvement by publishing a single
      editorial article that self-cited 66 of its own articles published either in the 
      year 2005 or 2006. The journal has been revoked of any JIF value in the following
      year of 2008. Thus, it is interesting to review the possible alternative
      bibliographical trend for the journal should the self-cite event has been
      avoided, the circumstances leading to the decision by the editor to publish such 
      an article and the possible ethical implications or lessons that can be derived
      from this incident.
FAU - Foo, Jong Yong Abdiel
AU  - Foo JY
AD  - Division of Research, Singapore General Hospital, 31 Third Hospital Avenue,
      Bowyer Block A Level 3, Outram Road, Singapore, 169608, Singapore.
      abdielfoo@hotmail.com
LA  - eng
PT  - Journal Article
DEP - 20091002
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Bibliometrics
MH  - Databases, Bibliographic
MH  - Editorial Policies
MH  - *Journal Impact Factor
MH  - Periodicals as Topic/*ethics
MH  - Publishing/*ethics
MH  - Switzerland
EDAT- 2009/10/03 06:00
MHDA- 2011/09/23 06:00
CRDT- 2009/10/03 06:00
PHST- 2009/07/17 00:00 [received]
PHST- 2009/09/14 00:00 [accepted]
PHST- 2009/10/03 06:00 [entrez]
PHST- 2009/10/03 06:00 [pubmed]
PHST- 2011/09/23 06:00 [medline]
AID - 10.1007/s11948-009-9177-7 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2011 Mar;17(1):65-73. doi: 10.1007/s11948-009-9177-7. Epub 2009
      Oct 2.


PMID- 19798587
OWN - NLM
STAT- MEDLINE
DCOM- 20110922
LR  - 20211020
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 17
IP  - 1
DP  - 2011 Mar
TI  - Acclimating international graduate students to professional engineering ethics.
PG  - 171-94
LID - 10.1007/s11948-009-9178-6 [doi]
AB  - This article describes the education portion of an ongoing grant-sponsored
      education and research project designed to help graduate students in all
      engineering disciplines learn about the basic ethical principles, rules, and
      obligations associated with engineering practice in the United States. While the 
      curriculum developed for this project is used for both domestic and international
      students, the educational materials were designed to be sensitive to the specific
      needs of international graduate students. In recent years, engineering programs
      in the United States have sought to develop a larger role for professional ethics
      education in the curriculum. Accreditation requirements, as well as pressures
      from the private sector, have helped facilitate this shift in focus. Almost half 
      of all engineering graduate students in the U.S. are international students.
      Further, research indicates that the majority of these students will remain in
      the U.S. to work post-graduation. It is therefore in the interest of the
      profession that these students, coming from diverse backgrounds, receive some
      formal exposure to the professional and ethical expectations and norms of the
      engineering profession in the United States to help ensure that they have the
      knowledge and skills--non-technical as well as technical--required in today's
      engineering profession. In becoming acculturated to professional norms in a host 
      country, international students face challenges that domestic students do not
      encounter; such as cultural competency, language proficiency, and acculturation
      stress. Mitigating these challenges must be a consideration in the development of
      any effective education materials. The present article discusses the project
      rationale and describes the development of on-line instructional materials aimed 
      at helping international engineering graduate students acclimate to professional 
      engineering ethics standards in the United States. Finally, a brief data summary 
      of students' perceptions of the usefulness of the content and instructional
      interface is provided to demonstrate the initial effectiveness of the materials
      and to present a case for project sustainability.
FAU - Newberry, Byron
AU  - Newberry B
AD  - Mechanical Engineering, Baylor University, Waco, TX, USA.
      Byron_Newberry@Baylor.edu
FAU - Austin, Katherine
AU  - Austin K
FAU - Lawson, William
AU  - Lawson W
FAU - Gorsuch, Greta
AU  - Gorsuch G
FAU - Darwin, Thomas
AU  - Darwin T
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20091002
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Accreditation
MH  - *Acculturation
MH  - Consumer Behavior
MH  - *Curriculum
MH  - *Education, Graduate
MH  - Engineering/*education/ethics
MH  - Ethics, Professional/*education
MH  - Humans
MH  - Internationality
MH  - Internet
MH  - *Professional Competence
MH  - Students
MH  - United States
EDAT- 2009/10/03 06:00
MHDA- 2011/09/23 06:00
CRDT- 2009/10/03 06:00
PHST- 2009/07/15 00:00 [received]
PHST- 2009/09/14 00:00 [accepted]
PHST- 2009/10/03 06:00 [entrez]
PHST- 2009/10/03 06:00 [pubmed]
PHST- 2011/09/23 06:00 [medline]
AID - 10.1007/s11948-009-9178-6 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2011 Mar;17(1):171-94. doi: 10.1007/s11948-009-9178-6. Epub 2009 
      Oct 2.


PMID- 19773220
OWN - NLM
STAT- MEDLINE
DCOM- 20110128
LR  - 20211028
IS  - 1468-2044 (Electronic)
IS  - 0003-9888 (Linking)
VI  - 96
IP  - 1
DP  - 2011 Jan
TI  - Ethics, governance and consent in the UK: implications for research into the
      longer-term outcomes of congenital heart defects.
PG  - 14-20
LID - 10.1136/adc.2008.152975 [doi]
AB  - OBJECTIVE: To explore the effect of research ethics, governance and consent
      requirements and recent reforms on UK-wide follow-up of children with congenital 
      heart defects (CHD). DESIGN: Prospective cohort study. SETTING: UK National
      Health Service. PATIENTS: 3897 children with CHD requiring intervention, or
      resulting in death, before they were 1-year-old (1993-1995). MAIN OUTCOMES:
      Impact on study protocol, timeliness and findings of a multicentre study of
      survival and quality of life. RESULTS: The peer-reviewed study protocol was
      altered to accommodate ethics committee stipulations that researchers should not 
      approach families directly with a request to participate and that the general
      practitioner's (GP) permission be sought before the local clinician could do so. 
      Individual consent was required to confirm the vital status of participants and
      for future tracing of public death registrations. Local study registration took a
      median of 40 weeks (IQR 25-57). 180 (24%) of 739 surviving children (five
      centres) could not be contacted because their GP was untraceable (32), had
      changed (128) or considered contact inappropriate (20). Invitations could not be 
      sent to 31% from the most deprived compared with 17% from the least deprived
      areas. CONCLUSIONS: Decision making concerning childhood interventions should be 
      influenced by evidence on long-term outcomes. However, current UK research
      regulations hinder follow-up in multicentre studies. Stipulations preventing
      researchers contacting families directly with research invitations appear
      disproportionate to the risks, impede equitable access to research opportunities 
      and introduce bias. The requirement for an individual's consent to confirm
      whether they are alive and monitor survival precludes effective long-term
      follow-up.
FAU - Knowles, Rachel L
AU  - Knowles RL
AD  - MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health,
      London, UK. r.knowles@ich.ucl.ac.uk
FAU - Bull, Catherine
AU  - Bull C
FAU - Wren, Christopher
AU  - Wren C
FAU - Dezateux, Carol
AU  - Dezateux C
LA  - eng
GR  - G0400546/MRC_/Medical Research Council/United Kingdom
GR  - PG/02/065/13934/BHF_/British Heart Foundation/United Kingdom
GR  - G106/1083/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20090921
PL  - England
TA  - Arch Dis Child
JT  - Archives of disease in childhood
JID - 0372434
SB  - IM
CIN - Arch Dis Child. 2011 Jan;96(1):3-4. PMID: 20554770
MH  - Child
MH  - Child, Preschool
MH  - Clinical Governance/*standards
MH  - Clinical Protocols/standards
MH  - Epidemiologic Methods
MH  - Ethics Committees, Research
MH  - Ethics, Medical
MH  - Family Practice/ethics
MH  - Heart Defects, Congenital/*mortality/rehabilitation
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Informed Consent/*ethics
MH  - Interprofessional Relations/ethics
MH  - Prognosis
MH  - Researcher-Subject Relations/ethics
MH  - State Medicine/ethics
MH  - United Kingdom/epidemiology
EDAT- 2009/09/24 06:00
MHDA- 2011/02/01 06:00
CRDT- 2009/09/24 06:00
PHST- 2009/09/24 06:00 [entrez]
PHST- 2009/09/24 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
AID - adc.2008.152975 [pii]
AID - 10.1136/adc.2008.152975 [doi]
PST - ppublish
SO  - Arch Dis Child. 2011 Jan;96(1):14-20. doi: 10.1136/adc.2008.152975. Epub 2009 Sep
      21.


PMID- 19760222
OWN - NLM
STAT- MEDLINE
DCOM- 20110929
LR  - 20211020
IS  - 1433-8726 (Electronic)
IS  - 0724-4983 (Linking)
VI  - 29
IP  - 3
DP  - 2011 Jun
TI  - Anatomical description of the periprostatic nerves in the male rhesus monkey
      (Macaca mulatta).
PG  - 375-80
LID - 10.1007/s00345-009-0473-2 [doi]
AB  - OBJECTIVES: Recent publications have revealed a variable course of the
      periprostatic nerves in humans. It is unclear to what extent nerves outside the
      dorsolateral region of the prostate are involved in the physiology of erectile
      function. As functional studies in humans are limited by ethical aspects
      investigations in animal models could provide further insight. The intention of
      this study was to give a detailed description of the topographical anatomy of
      autonomic nerves along the seminal vesicles and the prostate in male rhesus
      monkeys (Macaca mulatta) to investigate its suitability as an animal model for
      future physiological studies. METHODS: Wholemount serial sections of pelvic organ
      blocks of ten male rhesus monkeys were investigated. Autonomic nerves were
      stained with an antibody against S100. RESULTS: Autonomic nerves were dispersed
      along the dorsolateral to the ventrolateral aspect of the capsule of the prostate
      within a layer of connective tissue. There was no accumulation of vessels and
      nerves in the dorsolateral position of the prostate. The prostate is located
      dorsally to the urethra and does not encircle it. No adjacent nerves were found
      in the cranial two-thirds of the seminal vesicles. CONCLUSIONS: The male rhesus
      monkey is limited suitable as an animal model for studies on the periprostatic
      nerves provided the following differences to humans are considered: the special
      topography of the prostate, the nerve course along the seminal vesicles and the
      missing nerve accumulation dorsolaterally to the prostate.
FAU - Ganzer, Roman
AU  - Ganzer R
AD  - Department of Urology, Krankenhaus St. Josef, University of Regensburg,
      Landshuter Strasse 65, 93053 Regensburg, Germany. roman.ganzer@gmx.de
FAU - Neuhaus, Jochen
AU  - Neuhaus J
FAU - Gratzke, Christian
AU  - Gratzke C
FAU - Blana, Andreas
AU  - Blana A
FAU - Wieland, Wolf F
AU  - Wieland WF
FAU - Stolzenburg, Jens-Uwe
AU  - Stolzenburg JU
LA  - eng
PT  - Journal Article
DEP - 20090916
PL  - Germany
TA  - World J Urol
JT  - World journal of urology
JID - 8307716
RN  - 0 (S100 Proteins)
SB  - IM
MH  - Animals
MH  - Autonomic Pathways/*anatomy & histology/physiology
MH  - Macaca mulatta/*anatomy & histology/physiology
MH  - Male
MH  - Models, Animal
MH  - Penile Erection/physiology
MH  - Prostate/*innervation
MH  - S100 Proteins/metabolism
MH  - Seminal Vesicles/innervation
EDAT- 2009/09/18 06:00
MHDA- 2011/10/01 06:00
CRDT- 2009/09/18 06:00
PHST- 2009/06/09 00:00 [received]
PHST- 2009/08/27 00:00 [accepted]
PHST- 2009/09/18 06:00 [entrez]
PHST- 2009/09/18 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - 10.1007/s00345-009-0473-2 [doi]
PST - ppublish
SO  - World J Urol. 2011 Jun;29(3):375-80. doi: 10.1007/s00345-009-0473-2. Epub 2009
      Sep 16.


PMID- 19728096
OWN - NLM
STAT- MEDLINE
DCOM- 20120124
LR  - 20211020
IS  - 1573-6571 (Electronic)
IS  - 0022-4197 (Linking)
VI  - 50
IP  - 3
DP  - 2011 Sep
TI  - Organ procurement and health care chaplaincy in Australia.
PG  - 743-59
LID - 10.1007/s10943-009-9279-1 [doi]
AB  - As part of an Australian national project, quantitative data via a survey were
      retrospectively obtained from 327 Australian health care chaplains (staff and
      volunteer chaplains) to initially identify chaplaincy participation in various
      bioethical issues-including organ procurement. Over a third of surveyed staff
      chaplains (38%) and almost a fifth of volunteer chaplains (19.2%) indicted that
      they had, in some way, been involved in organ procurement issues with patients
      and/or their families. Nearly one-fifth of staff chaplains (19%) and 12% of
      volunteer chaplains had also assisted clinical staff concerning various organ
      procurement issues. One hundred of the surveyed chaplains volunteered to an
      interview. Qualitative data were subsequently coded from 42 of the chaplains who 
      had been involved in organ procurement requests. These data were thematically
      coded using the World Health Organization 'Pastoral Intervention Codings'
      (WHO-PICs). The qualitative data revealed that through a variety of pastoral
      interventions a number of chaplains (the majority being staff chaplains) were
      engaged in the critical and sensitive issues of organ procurement. It is argued
      that while such involvement can help to ensure a holistic and ethically
      appropriate practice, it is suggested that chaplains could be better utilized not
      only in the organ procurement process but also for the training of other
      chaplains and clinicians.
FAU - Carey, Lindsay B
AU  - Carey LB
AD  - Palliative Care Unit, School of Public Health, La Trobe University, Melbourne,
      VIC, 3000, Australia. lindsay.carey@latrobe.edu.au
FAU - Robinson, Priscilla
AU  - Robinson P
FAU - Cohen, Jeffrey
AU  - Cohen J
LA  - eng
PT  - Journal Article
DEP - 20090829
PL  - United States
TA  - J Relig Health
JT  - Journal of religion and health
JID - 2985199R
SB  - IM
MH  - Australia
MH  - Chaplaincy Service, Hospital
MH  - *Clergy
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - *Pastoral Care/education/methods
MH  - *Professional Role
MH  - Tissue and Organ Procurement/*statistics & numerical data
MH  - Workforce
EDAT- 2009/09/04 06:00
MHDA- 2012/01/25 06:00
CRDT- 2009/09/04 06:00
PHST- 2009/07/27 00:00 [received]
PHST- 2009/08/07 00:00 [accepted]
PHST- 2009/09/04 06:00 [entrez]
PHST- 2009/09/04 06:00 [pubmed]
PHST- 2012/01/25 06:00 [medline]
AID - 10.1007/s10943-009-9279-1 [doi]
PST - ppublish
SO  - J Relig Health. 2011 Sep;50(3):743-59. doi: 10.1007/s10943-009-9279-1. Epub 2009 
      Aug 29.


PMID- 19709079
OWN - NLM
STAT- MEDLINE
DCOM- 20111019
LR  - 20191210
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 25
IP  - 6
DP  - 2011 Jul
TI  - Applying the four-principle approach.
PG  - 293-300
LID - 10.1111/j.1467-8519.2009.01757.x [doi]
AB  - The four-principle approach to biomedical ethics is used worldwide by
      practitioners and researchers alike but it is rather unclear what exactly people 
      do when they apply this approach. Ranking, specification, and balancing vary
      greatly among different people regarding a particular case. Thus, a sound and
      coherent applicability of principlism seems somewhat mysterious. What are
      principlists doing? The article examines the methodological strengths and
      weaknesses of the applicability of this approach. The most important result is
      that a sound and comprehensible application of the four principles is
      additionally ensured by making use of the organizing meta-principle of common
      morality, which is the starting point and constraining framework of moral
      reasoning.
CI  - (c) 2009 Blackwell Publishing Ltd.
FAU - Gordon, John-Stewart
AU  - Gordon JS
AD  - Queen's University in Kingston, Canada Ruhr-University, Germany.
      jsgordon@queensu.ca
FAU - Rauprich, Oliver
AU  - Rauprich O
FAU - Vollmann, Jochen
AU  - Vollmann J
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090825
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
CIN - Bioethics. 2011 Jul;25(6):301-3. PMID: 21649684
MH  - Aged, 80 and over
MH  - *Beneficence
MH  - *Bioethical Issues
MH  - Conflict, Psychological
MH  - Dissent and Disputes
MH  - Female
MH  - Humans
MH  - *Morals
MH  - *Personal Autonomy
MH  - *Principle-Based Ethics
MH  - Treatment Refusal/ethics
MH  - Withholding Treatment/*ethics
EDAT- 2009/08/28 09:00
MHDA- 2011/10/20 06:00
CRDT- 2009/08/28 09:00
PHST- 2009/08/28 09:00 [entrez]
PHST- 2009/08/28 09:00 [pubmed]
PHST- 2011/10/20 06:00 [medline]
AID - BIOT1757 [pii]
AID - 10.1111/j.1467-8519.2009.01757.x [doi]
PST - ppublish
SO  - Bioethics. 2011 Jul;25(6):293-300. doi: 10.1111/j.1467-8519.2009.01757.x. Epub
      2009 Aug 25.


PMID- 19709078
OWN - NLM
STAT- MEDLINE
DCOM- 20110823
LR  - 20110412
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 25
IP  - 4
DP  - 2011 May
TI  - The virtue ethics approach to bioethics.
PG  - 192-201
LID - 10.1111/j.1467-8519.2009.01758.x [doi]
AB  - This paper discusses the viability of a virtue-based approach to bioethics.
      Virtue ethics is clearly appropriate to addressing issues of professional
      character and conduct. But another major remit of bioethics is to evaluate the
      ethics of biomedical procedures in order to recommend regulatory policy. How
      appropriate is the virtue ethics approach to fulfilling this remit? The first
      part of this paper characterizes the methodology problem in bioethics in terms of
      diversity, and shows that virtue ethics does not simply restate this problem in
      its own terms. However, fatal objections to the way the virtue ethics approach is
      typically taken in bioethics literature are presented in the second section of
      the paper. In the third part, a virtue-based approach to bioethics that avoids
      the shortcomings of the typical one is introduced and shown to be prima facie
      plausible. The upshot is an inviting new direction for research into bioethics'
      methodology.
CI  - (c) 2009 Blackwell Publishing Ltd.
FAU - Holland, Stephen
AU  - Holland S
AD  - Department of Philosophy, University of York, Heslington, UK. smh12@york.ac.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - *Bioethics
MH  - Cultural Diversity
MH  - *Ethical Theory
MH  - Humans
MH  - Politics
MH  - *Virtues
EDAT- 2009/08/28 09:00
MHDA- 2011/08/24 06:00
CRDT- 2009/08/28 09:00
PHST- 2009/08/28 09:00 [entrez]
PHST- 2009/08/28 09:00 [pubmed]
PHST- 2011/08/24 06:00 [medline]
AID - BIOT1758 [pii]
AID - 10.1111/j.1467-8519.2009.01758.x [doi]
PST - ppublish
SO  - Bioethics. 2011 May;25(4):192-201. doi: 10.1111/j.1467-8519.2009.01758.x.


PMID- 19659857
OWN - NLM
STAT- MEDLINE
DCOM- 20110422
LR  - 20101216
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 25
IP  - 1
DP  - 2011 Jan
TI  - Authorizing psychiatric research: principles, practices and problems.
PG  - 27-36
LID - 10.1111/j.1467-8519.2009.01741.x [doi]
AB  - Psychiatric research is advancing rapidly, with studies revealing new
      investigative tools and technologies that are aimed at improving the treatment
      and care of patients with psychiatric disorders. However, the ethical framework
      in which such research is conducted is not as well developed as we might expect. 
      In this paper we argue that more thought needs to be given to the principles that
      underpin research in psychiatry and to the problems associated with putting those
      principles into practice. In particular, we comment on some of the difficulties
      posed by the twin imperatives of ensuring that we respect the autonomy and
      interests of the research subject and, at the same time, enable potentially
      beneficial psychiatric research to flourish. We do not purport to offer a
      blueprint for the future; we do, however, seek to advance the debate by
      identifying some of the key questions to which better answers are required.
CI  - (c) 2009 Blackwell Publishing Ltd.
FAU - Chong, Siow Ann
AU  - Chong SA
AD  - Institute of Mental Health, Singapore. siow_ann_chong@imh.com.sg
FAU - Huxtable, Richard
AU  - Huxtable R
FAU - Campbell, Alastair
AU  - Campbell A
LA  - eng
PT  - Journal Article
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Mental Competency
MH  - *Mental Disorders
MH  - *Personal Autonomy
MH  - Psychiatry/*ethics
MH  - Schizophrenia
MH  - Social Responsibility
MH  - Third-Party Consent/ethics
MH  - *Vulnerable Populations
EDAT- 2009/08/08 09:00
MHDA- 2011/04/26 06:00
CRDT- 2009/08/08 09:00
PHST- 2009/08/08 09:00 [entrez]
PHST- 2009/08/08 09:00 [pubmed]
PHST- 2011/04/26 06:00 [medline]
AID - BIOT1741 [pii]
AID - 10.1111/j.1467-8519.2009.01741.x [doi]
PST - ppublish
SO  - Bioethics. 2011 Jan;25(1):27-36. doi: 10.1111/j.1467-8519.2009.01741.x.


PMID- 19659855
OWN - NLM
STAT- MEDLINE
DCOM- 20110422
LR  - 20220331
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 25
IP  - 1
DP  - 2011 Jan
TI  - Going from principles to rules in research ethics.
PG  - 9-20
LID - 10.1111/j.1467-8519.2009.01744.x [doi]
AB  - In research ethics there is a canon regarding what ethical rules ought to be
      followed by investigators vis-a-vis their treatment of subjects and a canon
      regarding what fundamental ethical principles apply to the endeavor. What I aim
      to demonstrate here is that several of the rules find no support in the
      principles. This leaves anyone who would insist that we not abandon those rules
      in the difficult position of needing to establish that we are nevertheless
      justified in believing in the validity of the rules. I conclude by arguing that
      this is not likely to be accomplished. The rules I call into question are the
      rules requiring: - that studies be designed in a scientifically valid way - that 
      risks to subjects be minimized - that subjects be afforded post-trial access to
      experimental interventions - that inducements paid to subjects not be counted as 
      a benefit to them - that inducements paid to subjects not be 'undue' - that
      subjects must remain free to withdraw from the study at any time for any reason
      without penalty. Both canons, the canon on principles and the canon on rules, are
      found in the overlap among ethical pronouncements that are themselves canonical: 
      the Nuremberg Code, the Declaration of Helsinki, the Belmont Report, CIOMS's
      International Ethical Guidelines for Biomedical Research Involving Human
      Subjects, and NBAC's 2001 report, Ethical Issues in International Research:
      Clinical Trials in Developing Countries.
CI  - (c) 2009 Blackwell Publishing Ltd.
FAU - Sachs, Benjamin
AU  - Sachs B
AD  - Center for Bioethics, New York University, USA. sachs@nyu.edu
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Beneficence
MH  - *Codes of Ethics
MH  - Coercion
MH  - Developing Countries
MH  - *Ethics, Research
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - International Cooperation
MH  - Patient Rights
MH  - Personhood
MH  - Research Design
MH  - Social Justice
EDAT- 2009/08/08 09:00
MHDA- 2011/04/26 06:00
CRDT- 2009/08/08 09:00
PHST- 2009/08/08 09:00 [entrez]
PHST- 2009/08/08 09:00 [pubmed]
PHST- 2011/04/26 06:00 [medline]
AID - BIOT1744 [pii]
AID - 10.1111/j.1467-8519.2009.01744.x [doi]
PST - ppublish
SO  - Bioethics. 2011 Jan;25(1):9-20. doi: 10.1111/j.1467-8519.2009.01744.x.


PMID- 19659853
OWN - NLM
STAT- MEDLINE
DCOM- 20110422
LR  - 20101216
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 25
IP  - 1
DP  - 2011 Jan
TI  - 'Early terminal sedation' is a distinct entity.
PG  - 46-54
LID - 10.1111/j.1467-8519.2009.01747.x [doi]
AB  - There has been much discussion regarding the acceptable use of sedation for
      palliation. A particularly contentious practice concerns deep, continuous
      sedation given to patients who are not imminently dying and given without
      provision of hydration or nutrition, with the end result that death is hastened. 
      This has been called 'early terminal sedation'. Early terminal sedation is a
      practice composed of two legally and ethically accepted treatment options. Under 
      certain conditions, patients have the right to reject hydration and nutrition,
      even if these are life-sustaining. Patients are also entitled to sedation as
      palliation for intolerable, intractable suffering. Though early terminal sedation
      is thought to be rare at present, the changing nature of palliative medicine
      suggests its use will increase. Arguments regarding early terminal sedation have 
      failed to recognize early terminal sedation as a distinct legal and ethical
      entity. It can be seen as both the simple sum of treatment refusal and sedation
      for palliation, analogous to terminal sedation. It can also be seen as an
      indivisible palliative treatment, more analogous to assisted suicide or
      euthanasia. But ultimately, it is wholly analogous neither to terminal sedation
      given when death is imminent, nor to assisted suicide or euthanasia. This paper
      contends that early terminal sedation should be considered as a distinct entity. 
      Such a reconception promises to provide a way forward in the debate, practice and
      policy regarding this contentious area of palliative medicine.
CI  - (c) 2009 Blackwell Publishing Ltd.
FAU - Cellarius, Victor
AU  - Cellarius V
AD  - Department of Family and Community Medicine, University of Toronto, Canada.
      victor.cellarius@utoronto.ca
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Deep Sedation/*ethics
MH  - Euthanasia/*ethics/legislation & jurisprudence
MH  - Humans
MH  - Palliative Care/*ethics/legislation & jurisprudence
MH  - Suicide, Assisted/*ethics/legislation & jurisprudence
MH  - Terminology as Topic
MH  - Treatment Refusal/*ethics/legislation & jurisprudence
EDAT- 2009/08/08 09:00
MHDA- 2011/04/26 06:00
CRDT- 2009/08/08 09:00
PHST- 2009/08/08 09:00 [entrez]
PHST- 2009/08/08 09:00 [pubmed]
PHST- 2011/04/26 06:00 [medline]
AID - BIOT1747 [pii]
AID - 10.1111/j.1467-8519.2009.01747.x [doi]
PST - ppublish
SO  - Bioethics. 2011 Jan;25(1):46-54. doi: 10.1111/j.1467-8519.2009.01747.x.


PMID- 19659851
OWN - NLM
STAT- MEDLINE
DCOM- 20110608
LR  - 20110202
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 25
IP  - 3
DP  - 2011 Mar
TI  - Reconsidering the value of consent in biobank research.
PG  - 155-66
LID - 10.1111/j.1467-8519.2009.01749.x [doi]
AB  - Biobanks for long-term research pose challenges to the legal and ethical validity
      of consent to participate. Different models of consent have been proposed to
      answer some of these challenges. This paper contributes to this discussion by
      considering the meaning and value of consent to participants in biobanks.
      Empirical data from a qualitative study is used to provide a participant view of 
      the consent process and to demonstrate that, despite limited understanding of the
      research, consent provides the research participants with some level of control
      and a form of self determination that they value. Participation is framed as a
      moral act of a responsible citizen providing reinforcement of self identity.
      Consent symbolizes the trust invested in researchers and research institutions to
      use the biobank for the public good. The paper argues that consent continues to
      play an important role in biobank participation and that a participant view
      should inform proposals to modify consent processes.
CI  - (c) 2009 Blackwell Publishing Ltd.
FAU - Allen, Judy
AU  - Allen J
AD  - Law School, The University of Western Australia, 35 Stirling Highway, Crawley,
      Western Australia 6009. jallen@law.uwa.edu.au
FAU - McNamara, Beverley
AU  - McNamara B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Australia
MH  - Biological Specimen Banks/*ethics
MH  - Biomedical Research/*ethics
MH  - Female
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Male
MH  - Middle Aged
MH  - Neoplasms
MH  - Research Subjects/*psychology
EDAT- 2009/08/08 09:00
MHDA- 2011/06/09 06:00
CRDT- 2009/08/08 09:00
PHST- 2009/08/08 09:00 [entrez]
PHST- 2009/08/08 09:00 [pubmed]
PHST- 2011/06/09 06:00 [medline]
AID - BIOT1749 [pii]
AID - 10.1111/j.1467-8519.2009.01749.x [doi]
PST - ppublish
SO  - Bioethics. 2011 Mar;25(3):155-66. doi: 10.1111/j.1467-8519.2009.01749.x.


PMID- 19594728
OWN - NLM
STAT- MEDLINE
DCOM- 20110608
LR  - 20211028
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 25
IP  - 3
DP  - 2011 Mar
TI  - Post-trial access to antiretrovirals: who owes what to whom?
PG  - 145-54
LID - 10.1111/j.1467-8519.2009.01736.x [doi]
AB  - Many recent articles argue that participants who seroconvert during HIV
      prevention trials deserve treatment when they develop AIDS, and there is a
      general consensus that the participants in HIV/AIDS treatment trials should have 
      continuing post-trial access. As a result, the primary concern of many ethicists 
      and activists has shifted from justifying an obligation to treat trial
      participants, to working out mechanisms through which treatment could be
      provided. In this paper I argue that this shift frequently conceals an important 
      assumption: that if there is an obligation to supply treatment, then any party
      who could provide it may be prevailed upon to discharge the obligation. This
      assumption is false. The reasons why trial participants should get ART affect who
      has the duty to provide it. We should not burden governments with the obligations
      of sponsors, nor researchers with the obligations of the international community.
      And we should not deprive a group of treatment because their need is less salient
      than that of research participants. Insisting otherwise may lead to people being 
      wrongfully deprived of access to antiretrovirals.
CI  - (c) 2009 Blackwell Publishing Ltd.
FAU - Millum, Joseph
AU  - Millum J
AD  - Clinical Center Department of Bioethics/Fogarty International Center, Building
      10, Room 1C118, NIH Clinical Center, National Institutes of Health, Bethesda, MD 
      20892, USA. millumj@cc.nih.gov
LA  - eng
GR  - Z99 CL999999/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
RN  - 0 (Anti-Retroviral Agents)
SB  - IM
MH  - Anti-Retroviral Agents/*therapeutic use
MH  - Bioethical Issues
MH  - Clinical Trials as Topic/*ethics
MH  - HIV Infections/*drug therapy/*prevention & control
MH  - Health Services Accessibility/*ethics
MH  - Humans
MH  - *Research Subjects
PMC - PMC2891643
MID - NIHMS138728
EDAT- 2009/07/15 09:00
MHDA- 2011/06/09 06:00
CRDT- 2009/07/15 09:00
PHST- 2009/07/15 09:00 [entrez]
PHST- 2009/07/15 09:00 [pubmed]
PHST- 2011/06/09 06:00 [medline]
AID - BIOT1736 [pii]
AID - 10.1111/j.1467-8519.2009.01736.x [doi]
PST - ppublish
SO  - Bioethics. 2011 Mar;25(3):145-54. doi: 10.1111/j.1467-8519.2009.01736.x.


PMID- 19594727
OWN - NLM
STAT- MEDLINE
DCOM- 20110422
LR  - 20101216
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 25
IP  - 1
DP  - 2011 Jan
TI  - Human dignity in international policy documents: a useful criterion for public
      policy?
PG  - 37-45
LID - 10.1111/j.1467-8519.2009.01737.x [doi]
AB  - Current developments in biomedicine are presenting us with difficult ethical
      decisions and raising complex policy questions about how to regulate these new
      developments. Particularly vexing for governments have been issues related to
      human embryo experimentation. Because some of the most promising biomedical
      developments, such as stem cell research and nuclear somatic transfer, involve
      such experimentation, several international bodies have drafted documents aimed
      to provide guidance to governments when developing biomedical science policy.
      Here I focus on two such documents: the Council of Europe's Convention for the
      Protection of Human Rights and Dignity of the Human Being and the Additional
      Protocol to the Convention for the Protection of Human Rights and Dignity of the 
      Human Being. I argue that by using human dignity as a criterion to determine the 
      permissibility of particular human embryo research practices, these documents
      cannot aid in identifying research that would be contrary to human dignity. Thus,
      they fail to guide public policy on embryo experimentation. Their use of human
      dignity as a criterion makes their task of offering guidance unfeasible because
      the concept as used in these documents is too vague and is applied in
      contradictory ways. I discuss the main goals of these documents and their claims 
      in relation to human embryo research. I then discuss how they have influenced
      public policy in several countries. Finally, I show that although these Council
      of Europe treaties attempt to serve as public policy guides in the area of embryo
      research, they fail to do so.
CI  - (c) 2009 Blackwell Publishing Ltd.
FAU - de Melo-Martin, Inmaculada
AU  - de Melo-Martin I
AD  - Weill Cornell Medical College, New York, NY 10065, USA. imd2001@med.cornell.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Bioethics
MH  - Embryo Research/*ethics/*legislation & jurisprudence
MH  - Europe
MH  - *Human Rights
MH  - Humans
MH  - *International Cooperation
MH  - *Personhood
MH  - *Public Policy
EDAT- 2009/07/15 09:00
MHDA- 2011/04/26 06:00
CRDT- 2009/07/15 09:00
PHST- 2009/07/15 09:00 [entrez]
PHST- 2009/07/15 09:00 [pubmed]
PHST- 2011/04/26 06:00 [medline]
AID - BIOT1737 [pii]
AID - 10.1111/j.1467-8519.2009.01737.x [doi]
PST - ppublish
SO  - Bioethics. 2011 Jan;25(1):37-45. doi: 10.1111/j.1467-8519.2009.01737.x.


PMID- 19594723
OWN - NLM
STAT- MEDLINE
DCOM- 20110422
LR  - 20101216
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 25
IP  - 1
DP  - 2011 Jan
TI  - Defending the duty to research?
PG  - 21-6
LID - 10.1111/j.1467-8519.2009.01745.x [doi]
AB  - In 2005, John Harris published a paper in the Journal of Medical Ethics in which 
      he claimed that there was a duty to support scientific research. With Sarah Chan,
      he defended his claims against criticisms in this journal in 2008. In this paper 
      I examine the defence, and claim that it is not powerful. Although he has
      established a slightly stronger position, it is not clear that the defence is
      sufficiently strong to show that there is a duty to support scientific research. 
      Important questions about fairness, about rescue, and about the relationship
      between reasons and obligations to act can still be raised; and these questions
      are important enough to destabilize the defence.
CI  - (c) 2009 Blackwell Publishing Ltd.
FAU - Brassington, Iain
AU  - Brassington I
AD  - University of Manchester, UK. iain.brassington@manchester.ac.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - *Biomedical Research
MH  - Humans
MH  - *Moral Obligations
MH  - Research Support as Topic/*ethics
MH  - Social Justice
EDAT- 2009/07/15 09:00
MHDA- 2011/04/26 06:00
CRDT- 2009/07/15 09:00
PHST- 2009/07/15 09:00 [entrez]
PHST- 2009/07/15 09:00 [pubmed]
PHST- 2011/04/26 06:00 [medline]
AID - BIOT1745 [pii]
AID - 10.1111/j.1467-8519.2009.01745.x [doi]
PST - ppublish
SO  - Bioethics. 2011 Jan;25(1):21-6. doi: 10.1111/j.1467-8519.2009.01745.x.


PMID- 19570597
OWN - NLM
STAT- MEDLINE
DCOM- 20110908
LR  - 20151119
IS  - 1532-3099 (Electronic)
IS  - 0266-6138 (Linking)
VI  - 27
IP  - 2
DP  - 2011 Apr
TI  - Assessing women's sexual life after childbirth: the role of the postnatal check.
PG  - 195-202
LID - 10.1016/j.midw.2009.04.003 [doi]
AB  - OBJECTIVE: to describe midwives' reflections on counselling women at the
      postnatal check with special focus on sexual life after childbirth. DESIGN:
      qualitative descriptive study with focus group discussions as the method of data 
      collection. SETTING: antenatal clinics in Stockholm greater catchments' area.
      PARTICIPANTS: during 2006 and 2007, a voluntary sample of midwives from 10
      different antenatal clinics were invited. ANALYSIS: content analysis was
      undertaken through identification of codes, categories and themes. FINDINGS: Two 
      themes emerged: balancing between personal perceptions of the woman's needs and
      the health system restrictions and strategies for counselling about sexual life
      after childbirth'. The midwives tried to create a picture for themselves of the
      woman coming for the postnatal check and her needs before the consultation. This 
      picture guided the midwives, but lack of time and knowledge restricted them when 
      counselling on sexual life after childbirth. Two different strategies in
      counselling were identified, one task-oriented and one subject-oriented. Demands 
      and time restrictions led midwives to distance themselves from their clients. A
      task-oriented approach was more visible in midwives' encounters with foreign-born
      women, where linguistic difficulties, cultural diversity and narrow time frames
      restricted the midwives' effectiveness and/or sensitivity as caregivers. In
      contrast, the subject-oriented strategy meant 'getting in tune', i.e. listening
      to the woman when she expressed her feelings and emotions, encouraging the woman 
      to be an active participant in decisions involving her care. This strategy is
      used for women who arouse midwives' empathy and when there is some form of
      recognition and understanding. CONCLUSION: The picture created of the woman and
      her needs guided the midwives, but lack of knowledge and time limitations
      restricted counselling on sexual life after childbirth. Two counselling
      strategies were identified, one task-oriented and one subject-oriented. Balancing
      these two counselling strategies improves both the ethical aspects and the
      quality of the counselling.
CI  - Copyright (c) 2009 Elsevier Ltd. All rights reserved.
FAU - Olsson, Ann
AU  - Olsson A
AD  - Department of Clinical Sciences, Division of Caring Science, Danderyd Hospital,
      Karolinska Institutet, Solna, Sweden. Ann.Olsson@ki.se
FAU - Robertson, Eva
AU  - Robertson E
FAU - Falk, Katarina
AU  - Falk K
FAU - Nissen, Eva
AU  - Nissen E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090701
PL  - Scotland
TA  - Midwifery
JT  - Midwifery
JID - 8510930
MH  - Adult
MH  - Cultural Competency
MH  - Female
MH  - Focus Groups
MH  - Humans
MH  - Middle Aged
MH  - *Nurse Midwives/ethics/psychology/standards
MH  - Nurse's Role
MH  - Nurse-Patient Relations/ethics
MH  - Parturition
MH  - *Postnatal Care/methods/organization & administration
MH  - Postpartum Period/*psychology
MH  - Pregnancy
MH  - Self Concept
MH  - *Sex Counseling/ethics/methods/standards
MH  - Sexual Behavior
MH  - *Sexual Dysfunction, Physiological/etiology/psychology/therapy
MH  - *Sexual Dysfunctions, Psychological/etiology/physiopathology/therapy
MH  - Surveys and Questionnaires
MH  - Transcultural Nursing
EDAT- 2009/07/03 09:00
MHDA- 2011/09/09 06:00
CRDT- 2009/07/03 09:00
PHST- 2008/11/21 00:00 [received]
PHST- 2009/04/17 00:00 [revised]
PHST- 2009/04/17 00:00 [accepted]
PHST- 2009/07/03 09:00 [entrez]
PHST- 2009/07/03 09:00 [pubmed]
PHST- 2011/09/09 06:00 [medline]
AID - S0266-6138(09)00057-6 [pii]
AID - 10.1016/j.midw.2009.04.003 [doi]
PST - ppublish
SO  - Midwifery. 2011 Apr;27(2):195-202. doi: 10.1016/j.midw.2009.04.003. Epub 2009 Jul
      1.


PMID- 19496016
OWN - NLM
STAT- MEDLINE
DCOM- 20111222
LR  - 20181201
IS  - 1573-1677 (Electronic)
IS  - 1382-4996 (Linking)
VI  - 16
IP  - 3
DP  - 2011 Aug
TI  - An ethical justification and policy for making commitments during computerized
      residency application processes: The US matching program as a laboratory for
      needed reform.
PG  - 427-33
LID - 10.1007/s10459-009-9167-1 [doi]
AB  - The US National Residency Matching Program (NRMP) is a computerized, national
      system for matching residency applicants to programs. Similar systems exist in
      Canada, Australia, and New Zealand, and the need for such a program will probably
      make itself felt in the European Union soon. NRMP is an important laboratory for 
      the ethical challenges that computerized matching programs create, especially its
      current prohibition of making commitments by both applicants and residency
      programs. Nonetheless, it would be denial to suppose that commitments are not
      being made and that there is no dishonesty when commitments are made. We analyze 
      the current NRMP no-commitment policy by reference to Plato's retelling of the
      myth of the Ring of Gyges, which makes its wearer physically invisible and
      therefore ethically unaccountable. Because applicants and programs complete their
      preference-lists in secret, the matching process inadvertently slips a Ring of
      Gyges on the fingers of both parties. As a result, making false commitments
      promotes the rational self-interest of both parties. To strengthen the
      professional integrity of the matching process, we argue that NRMP should abandon
      its no-commitment policy and adopt a new paradigm: sanctioning honest,
      non-contingent, accountable, one-party, and documented commitments. Computerized 
      residency matching systems in other countries should consider the NRMP a
      laboratory and develop policies about making commitments that promote
      professionalism in the residency application process.
FAU - Chervenak, Frank A
AU  - Chervenak FA
AD  - Department of Obstetrics and Gynecology, Weill Medical College of Cornell
      University, New York, NY, USA. fac2001@med.cornell.edu
FAU - McCullough, Laurence B
AU  - McCullough LB
FAU - Cefalo, Robert
AU  - Cefalo R
LA  - eng
PT  - Journal Article
DEP - 20090604
PL  - Netherlands
TA  - Adv Health Sci Educ Theory Pract
JT  - Advances in health sciences education : theory and practice
JID - 9612021
SB  - IM
MH  - Education, Medical, Graduate
MH  - Efficiency, Organizational/*ethics
MH  - Ethics, Professional
MH  - Humans
MH  - Internship and Residency/*ethics
MH  - Models, Organizational
MH  - Organizational Culture
MH  - *Organizational Policy
MH  - Social Responsibility
MH  - United States
MH  - Workforce
EDAT- 2009/06/06 09:00
MHDA- 2011/12/23 06:00
CRDT- 2009/06/05 09:00
PHST- 2009/03/25 00:00 [received]
PHST- 2009/05/15 00:00 [accepted]
PHST- 2009/06/05 09:00 [entrez]
PHST- 2009/06/06 09:00 [pubmed]
PHST- 2011/12/23 06:00 [medline]
AID - 10.1007/s10459-009-9167-1 [doi]
PST - ppublish
SO  - Adv Health Sci Educ Theory Pract. 2011 Aug;16(3):427-33. doi:
      10.1007/s10459-009-9167-1. Epub 2009 Jun 4.


PMID- 19462159
OWN - NLM
STAT- MEDLINE
DCOM- 20110805
LR  - 20161125
IS  - 1573-1677 (Electronic)
IS  - 1382-4996 (Linking)
VI  - 16
IP  - 2
DP  - 2011 May
TI  - Student participation in health professions education research: in pursuit of the
      Aristotelian mean.
PG  - 277-86
LID - 10.1007/s10459-009-9164-4 [doi]
AB  - In research ethics reviews, traditional approaches of research ethics boards
      (REBs) balance the risks with the potential for benefit of proposed studies, and 
      this review process has been similar for health professions education research
      (HPER) as it has been for clinically based studies. Health professions students
      are the primary population from which most education researchers draw their
      participants although relatively little discussion has taken place in the
      literature regarding student participation in HPER. The majority of HPER studies 
      could be considered minimal risk and therefore many have suggested that such
      studies be exempted from REB review. However, there are not only risks to student
      participants which require consideration, but I argue that when this issue is
      viewed through the lens of Aristotle's virtue ethics, there are also potential
      benefits to the student, for which REB oversight can be helpful, that have not
      factored strongly into discussions. This paper seeks to highlight the key factors
      involved in student participation in HPER; to explore Aristotle's doctrine of the
      mean and to evaluate how this ethical framework can add value to the discussion; 
      and to propose possible applications of the Aristotelian mean to this issue and
      address some of the challenges that would arise with its application.
FAU - Chen, Ruth P
AU  - Chen RP
AD  - Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
      chenrp@mcmaster.ca
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20090522
PL  - Netherlands
TA  - Adv Health Sci Educ Theory Pract
JT  - Advances in health sciences education : theory and practice
JID - 9612021
SB  - IM
MH  - *Community Participation
MH  - *Ethics, Medical
MH  - Ethics, Research
MH  - Faculty, Medical
MH  - Health Occupations/*education/ethics
MH  - Health Services Research
MH  - Humans
MH  - Ontario
MH  - Personal Autonomy
MH  - *Philosophy
MH  - Students, Medical/psychology
MH  - *Teaching
EDAT- 2009/05/23 09:00
MHDA- 2011/08/06 06:00
CRDT- 2009/05/23 09:00
PHST- 2008/09/23 00:00 [received]
PHST- 2009/05/05 00:00 [accepted]
PHST- 2009/05/23 09:00 [entrez]
PHST- 2009/05/23 09:00 [pubmed]
PHST- 2011/08/06 06:00 [medline]
AID - 10.1007/s10459-009-9164-4 [doi]
PST - ppublish
SO  - Adv Health Sci Educ Theory Pract. 2011 May;16(2):277-86. doi:
      10.1007/s10459-009-9164-4. Epub 2009 May 22.


PMID- 19346410
OWN - NLM
STAT- MEDLINE
DCOM- 20110420
LR  - 20211020
IS  - 1524-8399 (Print)
IS  - 1524-8399 (Linking)
VI  - 12
IP  - 1
DP  - 2011 Jan
TI  - The role of community health workers (CHWs) in health promotion research: ethical
      challenges and practical solutions.
PG  - 86-93
LID - 10.1177/1524839908330809 [doi]
AB  - This article aims to describe the role of community health workers (CHWs) in
      health promotion research and address the challenges and ethical concerns
      associated with this research approach. A series of six focus groups are
      conducted with project managers and investigators (n = 5 to 11 per session) who
      have worked with CHWs in health promotion research. These focus groups are part
      of a larger study funded by the National Institutes of Health titled "Training in
      Research Ethics and Standards" (Project TRES). Participants are asked to describe
      their training needs for CHWs with respect to human subject protections as well
      as to identify associated challenges regarding research practice (i.e.,
      recruitment, random assignment, protocol implementation, etc.). Findings reveal a
      number of challenges that investigators and project managers encounter when
      working with CHWs on research projects involving the community. These include
      characteristics inherent to CHWs such as education level and personal beliefs
      about their own community and its needs, institutional regulations regarding
      research practice, and problems inherent to research studies such as training
      materials and protocols that cannot account for the complexity of conducting
      research in community settings. Investigators should carefully consider the role 
      that CHWs have in their communities before creating research programs that depend
      on the CHWs' existing social networks and their propensity to be natural helpers.
      These strengths could lead to compromises in research requirements for random
      assignment, control groups, and fully informed consent.
FAU - Terpstra, Jennifer
AU  - Terpstra J
AD  - Interdisciplinary Studies Graduate Program, University of British Columbia in
      Vancouver, British Columbia, Canada.
FAU - Coleman, Karen J
AU  - Coleman KJ
FAU - Simon, Gayle
AU  - Simon G
FAU - Nebeker, Camille
AU  - Nebeker C
LA  - eng
GR  - T15 HL072440/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20090403
PL  - United States
TA  - Health Promot Pract
JT  - Health promotion practice
JID - 100890609
SB  - IM
MH  - Adult
MH  - *Community Health Workers
MH  - Female
MH  - Health Promotion/*ethics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Netherlands
MH  - *Professional Role
MH  - Qualitative Research
MH  - Workforce
PMC - PMC3748275
MID - NIHMS489749
EDAT- 2009/04/07 09:00
MHDA- 2011/04/22 06:00
CRDT- 2009/04/07 09:00
PHST- 2009/04/07 09:00 [entrez]
PHST- 2009/04/07 09:00 [pubmed]
PHST- 2011/04/22 06:00 [medline]
AID - 1524839908330809 [pii]
AID - 10.1177/1524839908330809 [doi]
PST - ppublish
SO  - Health Promot Pract. 2011 Jan;12(1):86-93. doi: 10.1177/1524839908330809. Epub
      2009 Apr 3.


PMID- 19345547
OWN - NLM
STAT- MEDLINE
DCOM- 20110608
LR  - 20110207
IS  - 0736-4679 (Print)
IS  - 0736-4679 (Linking)
VI  - 40
IP  - 2
DP  - 2011 Feb
TI  - Exploring the limits of autonomy.
PG  - 229-32
LID - 10.1016/j.jemermed.2009.02.029 [doi]
AB  - BACKGROUND: The ethical principle of autonomy is explored as it applies to
      situations in which patients' capacities to make decisions are questionable. CASE
      REPORT: A 40-year-old man presented to the Emergency Department with an epidural 
      hematoma, and refused to undergo emergent surgical treatment. Considering the
      acutely life-threatening nature of his problem and the inability to confirm the
      patient's capacity in the presence of a traumatic brain injury, the decision was 
      made to proceed with emergent surgical treatment without consent. DISCUSSION: The
      concept of conditional autonomy is introduced, defined, and employed to defend
      the process whereby a select group of patients may be treated without full
      knowledge of their wishes.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Shuman, Andrew G
AU  - Shuman AG
AD  - University of Michigan Medical School, Ann Arbor, Michigan, USA.
FAU - Barnosky, Andrew R
AU  - Barnosky AR
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20090405
PL  - United States
TA  - J Emerg Med
JT  - The Journal of emergency medicine
JID - 8412174
SB  - IM
MH  - Adult
MH  - Hematoma, Epidural, Cranial/surgery
MH  - Humans
MH  - Male
MH  - Mental Competency
MH  - Patient Rights/*ethics
MH  - *Personal Autonomy
MH  - Treatment Refusal/*ethics
EDAT- 2009/04/07 09:00
MHDA- 2011/06/09 06:00
CRDT- 2009/04/07 09:00
PHST- 2008/10/28 00:00 [received]
PHST- 2008/12/16 00:00 [revised]
PHST- 2009/02/06 00:00 [accepted]
PHST- 2009/04/07 09:00 [entrez]
PHST- 2009/04/07 09:00 [pubmed]
PHST- 2011/06/09 06:00 [medline]
AID - S0736-4679(09)00118-8 [pii]
AID - 10.1016/j.jemermed.2009.02.029 [doi]
PST - ppublish
SO  - J Emerg Med. 2011 Feb;40(2):229-32. doi: 10.1016/j.jemermed.2009.02.029. Epub
      2009 Apr 5.


PMID- 19342134
OWN - NLM
STAT- MEDLINE
DCOM- 20110908
LR  - 20110404
IS  - 1532-3099 (Electronic)
IS  - 0266-6138 (Linking)
VI  - 27
IP  - 2
DP  - 2011 Apr
TI  - Rhetorical skills as a component of midwifery care.
PG  - 125-30
LID - 10.1016/j.midw.2009.02.005 [doi]
AB  - OBJECTIVE: this article argues that rhetorical skills are an important quality
      factor of midwifery care. In particular, it aims to identify and discuss the
      relevance of three classical means of persuasion: ethos, pathos and logos.
      DESIGN: secondary analysis, rhetorical analysis of semi-structured interviews.
      SETTING: Slovenia. Interviews were carried out predominantly in 2006. Data refer 
      to childbirths in 2005 and 2006. PARTICIPANTS: four women with recent experience 
      of childbirth. FINDINGS: analysis identified the presence of all three means of
      persuasion in the interaction between midwives and women. Focusing on midwives,
      the quality of their awareness and command of rhetorical skills remains
      questionable. In particular, women experienced lack of a rational account of the 
      situation and decisions made by health-care professionals involved in maternity
      care. KEY CONCLUSIONS: acknowledging professional ethics, awareness and good
      command of all three means of persuasion [but above all, argumentative persuasion
      (logos)] is an integral component of midwifery care. It can contribute to
      collaborative relations between midwives and women, and thus promote
      women-centred midwifery care. IMPLICATIONS FOR PRACTICE: knowledge of the three
      classical rhetorical means of persuasion should be integrated into professional
      midwifery curricula.
CI  - Copyright (c) 2009 Elsevier Ltd. All rights reserved.
FAU - Domajnko, Barbara
AU  - Domajnko B
AD  - University of Ljubljana, College of Health Studies, Poljanska 26a, 1000
      Ljubljana, Slovenia. barbara.domajnko@vsz.uni-lj.si
FAU - Drglin, Zalka
AU  - Drglin Z
FAU - Pahor, Majda
AU  - Pahor M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090401
PL  - Scotland
TA  - Midwifery
JT  - Midwifery
JID - 8510930
MH  - Clinical Competence/standards
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Maternal Health Services/standards
MH  - Midwifery/*education/*ethics/standards
MH  - Nurse's Role/*psychology
MH  - Nurse-Patient Relations/ethics
MH  - Patient-Centered Care/standards
MH  - *Persuasive Communication
MH  - Pregnancy
EDAT- 2009/04/04 09:00
MHDA- 2011/09/09 06:00
CRDT- 2009/04/04 09:00
PHST- 2008/09/20 00:00 [received]
PHST- 2009/02/04 00:00 [revised]
PHST- 2009/02/14 00:00 [accepted]
PHST- 2009/04/04 09:00 [entrez]
PHST- 2009/04/04 09:00 [pubmed]
PHST- 2011/09/09 06:00 [medline]
AID - S0266-6138(09)00025-4 [pii]
AID - 10.1016/j.midw.2009.02.005 [doi]
PST - ppublish
SO  - Midwifery. 2011 Apr;27(2):125-30. doi: 10.1016/j.midw.2009.02.005. Epub 2009 Apr 
      1.


PMID- 19130279
OWN - NLM
STAT- MEDLINE
DCOM- 20110804
LR  - 20110412
IS  - 1573-1677 (Electronic)
IS  - 1382-4996 (Linking)
VI  - 16
IP  - 1
DP  - 2011 Mar
TI  - Should professional ethics education incorporate single-professional or
      interprofessional learning?
PG  - 143-6
LID - 10.1007/s10459-008-9150-2 [doi]
AB  - Since ethical issues in the contemporary delivery of health care involve doctors,
      nurses, technicians, and members of other health professions, the authors
      consider whether members of diverse health care occupations might benefit from
      studying ethics in a single classroom. While interprofessional courses may be
      better at teaching the ethics of the relationships between and among the various 
      health professions, single-professional courses may be better at teaching the
      ethics of relationships between particular kinds of professionals and patients.
      An ethics instructor's professional discipline affects his/her credibility with
      the students, and the course readings may not always be relevant to the actual
      work of a given discipline. With these challenges in mind, the authors suggest
      that the boundaries of ethics education in the health professions be reconceived 
      to accommodate the professional mission of a specific discipline as well as the
      interdependence and collaboration that marks high quality health care.
FAU - Caldicott, Catherine V
AU  - Caldicott CV
AD  - Center for Bioethics and Humanities, SUNY Upstate Medical University, 725 Irving 
      Avenue, Suite 406, Syracuse, NY 13210, USA. caldicoc@upstate.edu
FAU - Braun, Eli A
AU  - Braun EA
LA  - eng
PT  - Journal Article
DEP - 20090108
PL  - Netherlands
TA  - Adv Health Sci Educ Theory Pract
JT  - Advances in health sciences education : theory and practice
JID - 9612021
SB  - IM
MH  - Curriculum
MH  - Education, Medical/*methods
MH  - Educational Status
MH  - Ethics, Professional/*education
MH  - Health Personnel
MH  - Humans
MH  - Interprofessional Relations/*ethics
MH  - *Learning
MH  - *Teaching
MH  - United States
EDAT- 2009/01/09 09:00
MHDA- 2011/08/05 06:00
CRDT- 2009/01/09 09:00
PHST- 2008/07/07 00:00 [received]
PHST- 2008/12/15 00:00 [accepted]
PHST- 2009/01/09 09:00 [entrez]
PHST- 2009/01/09 09:00 [pubmed]
PHST- 2011/08/05 06:00 [medline]
AID - 10.1007/s10459-008-9150-2 [doi]
PST - ppublish
SO  - Adv Health Sci Educ Theory Pract. 2011 Mar;16(1):143-6. doi:
      10.1007/s10459-008-9150-2. Epub 2009 Jan 8.


PMID- 22912190
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20120822
IS  - 0334-0139 (Print)
IS  - 0334-0139 (Linking)
VI  - 7
IP  - 3
DP  - 2011 May 18
TI  - Sex, mental retardation and ethics.
PG  - 193-8
LID - 10.1515/IJAMH.1994.7.3.193 [doi]
LID - /j/ijamh.1994.7.3/ijamh.1994.7.3.193/ijamh.1994.7.3.193.xml [pii]
FAU - Zucker-Weiss, R
AU  - Zucker-Weiss R
LA  - eng
PT  - Journal Article
DEP - 20110518
PL  - Germany
TA  - Int J Adolesc Med Health
JT  - International journal of adolescent medicine and health
JID - 8506960
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 2012/08/23 06:00
PHST- 2012/08/23 06:00 [entrez]
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
AID - 10.1515/IJAMH.1994.7.3.193 [doi]
AID - /j/ijamh.1994.7.3/ijamh.1994.7.3.193/ijamh.1994.7.3.193.xml [pii]
PST - epublish
SO  - Int J Adolesc Med Health. 2011 May 18;7(3):193-8. doi:
      10.1515/IJAMH.1994.7.3.193.


PMID- 22912082
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20120822
IS  - 0334-0139 (Print)
IS  - 0334-0139 (Linking)
VI  - 4
IP  - 1
DP  - 2011 May 18
TI  - Medical decisions: ethical dilemmas.
PG  - 35-40
LID - 10.1515/IJAMH.1989.4.1.35 [doi]
LID - /j/ijamh.1989.4.1/ijamh.1989.4.1.35/ijamh.1989.4.1.35.xml [pii]
FAU - Hammes, E L J
AU  - Hammes EL
FAU - Christiaens, Mu
AU  - Christiaens M
LA  - eng
PT  - Journal Article
DEP - 20110518
PL  - Germany
TA  - Int J Adolesc Med Health
JT  - International journal of adolescent medicine and health
JID - 8506960
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 2012/08/23 06:00
PHST- 2012/08/23 06:00 [entrez]
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
AID - 10.1515/IJAMH.1989.4.1.35 [doi]
AID - /j/ijamh.1989.4.1/ijamh.1989.4.1.35/ijamh.1989.4.1.35.xml [pii]
PST - epublish
SO  - Int J Adolesc Med Health. 2011 May 18;4(1):35-40. doi: 10.1515/IJAMH.1989.4.1.35.


PMID- 22912030
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20120822
IS  - 0334-0139 (Print)
IS  - 0334-0139 (Linking)
VI  - 2
IP  - 2
DP  - 2011 May 18
TI  - Ethical considerations in the medical care of adolescents consulting for
      treatment of sexually transmitted diseases.
PG  - 153-8
LID - 10.1515/IJAMH.1986.2.2.153 [doi]
LID - /j/ijamh.1986.2.2/ijamh.1986.2.2.153/ijamh.1986.2.2.153.xml [pii]
FAU - Silber, Tomas Jose
AU  - Silber TJ
LA  - eng
PT  - Journal Article
DEP - 20110518
PL  - Germany
TA  - Int J Adolesc Med Health
JT  - International journal of adolescent medicine and health
JID - 8506960
EDAT- 1986/01/01 00:00
MHDA- 1986/01/01 00:01
CRDT- 2012/08/23 06:00
PHST- 2012/08/23 06:00 [entrez]
PHST- 1986/01/01 00:00 [pubmed]
PHST- 1986/01/01 00:01 [medline]
AID - 10.1515/IJAMH.1986.2.2.153 [doi]
AID - /j/ijamh.1986.2.2/ijamh.1986.2.2.153/ijamh.1986.2.2.153.xml [pii]
PST - epublish
SO  - Int J Adolesc Med Health. 2011 May 18;2(2):153-8. doi:
      10.1515/IJAMH.1986.2.2.153.


PMID- 30907998
STAT- Publisher
DA  - 20190326
PB  - RTI Press
CTI - RTI Press Occasional Papers
DP  - 2012 Dec
BTI - Functional Magnetic Resonance Imaging (fMRI): An Invaluable Tool in Translational
      Neuroscience
LID - 10.3768/rtipress.2012.op.0010.1212 [doi]
AB  - The sophisticated methods of neuroscience-including molecular genetics,
      structural and functional neuroimaging, animal models, and experimental tasks
      that approximate real-world behaviors in human research-have yielded important
      insights about typical functioning and neurobehavioral disorders. Translational
      neuroscience endeavors to use this knowledge to improve the human condition by
      developing and improving interventions for these disorders. This paper reviews
      the literature on the contribution of functional magnetic resonance imaging
      (fMRI) and two related techniques, resting-state fMRI (rs-fMRI) and real-time
      fMRI (rt-fMRI), to the diagnosis and treatment of behavioral problems and
      psychiatric disorders. It also explains how incorporating neuroscience principles
      and techniques into research on the prevention of substance misuse and antisocial
      behavior may spur advances and innovations in this important area. This article
      argues that fMRI's potential contribution to these prevention efforts has yet to 
      be fully realized, explores new ways in which the technique could be adapted to
      that end, highlights some of the work by researchers in the vanguard of this
      effort, and notes limitations of fMRI and ethical concerns the technique raises.
CI  - (c) 2012 Research Triangle Institute. All rights reserved.
FAU - Whitten, Lori A
AU  - Whitten LA
LA  - eng
PT  - Review
PT  - Book
PL  - Research Triangle Park (NC)
EDAT- 2019/03/26 06:01
MHDA- 2019/03/26 06:01
CDAT- 2019/03/26 06:01
AID - NBK538909 [bookaccession]
AID - 10.3768/rtipress.2012.op.0010.1212 [doi]


PMID- 29913782
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1877-8879 (Electronic)
IS  - 1877-8860 (Linking)
VI  - 3
IP  - 2
DP  - 2012 Apr 1
TI  - Translational animal models using veterinary patients - An example of canine
      osteoarthritis (OA).
PG  - 84-89
LID - 10.1016/j.sjpain.2011.11.007 [doi]
LID - /j/sjpain.2012.3.issue-2/j.sjpain.2011.11.007/j.sjpain.2011.11.007.xml [pii]
AB  - Background and purpose The use of laboratory animals in pain research has
      powerfully contributed to our detailed understanding of the physiological
      mechanisms of pain. Animal models also represent an essential tool to screen and 
      select novel drug molecules with potentially analgesic properties. Despite of the
      inevitable input of laboratory animal trials, recent studies have shown that
      animal pain models have repeatedly failed to predict clinical analgesic efficacy 
      and adverse side effects of potential drug molecules in human pain patients. This
      paper provides a review of the laboratory animal models of OA, which have been
      developed to test efficacy of novel analgesics. The paper also presents
      spontaneous OA in canine veterinary patients, and methods to observe chronic pain
      in nonverbal dogs. Methods PubMed data base was searched as a reference list to
      locate most relevant articles. A number of 118 articles including 4 reviews were 
      located. Web pages of 4 establishments and 2 private organizations were also
      accessed. Results The clinical expression and pathogenesis of naturally occurring
      OA in dogs is considered an analogous disease that occurs in humans, including
      pain and lameness. OA may occur in any joint in dogs as well as in humans.
      Primary idiopathic OA in dogs is rare, but certain breeds may be predisposed to
      it. For the most part, canine OA is considered secondary to acquired or
      congenital musculoskeletal disorders. Concomitant factors, such as aging and
      obesity, likely accelerate progression. However, mechanical factors appear to
      predominate in the etiopathogenesis of canine spontaneous OA. Both subjective
      (validated questionnaire) and objective (gait analysis) tools are available to
      measure OA related pain in dogs. Information on the prevalence of canine OA is
      limited, but rough surveys suggest that 11 million dogs in the United States and 
      5 million in Europe could suffer from OA. Ethical considerations concerning the
      use of privately owned dogs can be resolved by a careful experimental design.
      Conclusion Canine spontaneous OA could serve as a translational animal model that
      would more closely mimick clinical OA related pain conditions in humans.
      Privately owned dogs would make a solution to fix the gap between animal pain
      models and clinical trials when testing potential analgesic drug molecules. Close
      interdisciplinary cooperation would guarantee that both scientific and ethical
      intentions would be achieved. Implications The predictability of translational
      pain research would improve by using privately owned dogs as chronic pain models 
      when testing novel analgesics.
FAU - Vainio, Outi
AU  - Vainio O
AD  - Faculty of Veterinary Medicine, POB 57, 00014 University of Helsinki, Helsinki,
      Finland.
LA  - eng
PT  - Journal Article
DEP - 20120401
PL  - Germany
TA  - Scand J Pain
JT  - Scandinavian journal of pain
JID - 101520867
OTO - NOTNLM
OT  - Animal model
OT  - Canine
OT  - OA
OT  - Osteoarthritis
OT  - Pet dog
OT  - Translational
EDAT- 2018/06/20 06:00
MHDA- 2018/06/20 06:01
CRDT- 2018/06/20 06:00
PHST- 2011/07/01 00:00 [received]
PHST- 2011/11/18 00:00 [accepted]
PHST- 2018/06/20 06:00 [entrez]
PHST- 2018/06/20 06:00 [pubmed]
PHST- 2018/06/20 06:01 [medline]
AID - 10.1016/j.sjpain.2011.11.007 [doi]
AID - /j/sjpain.2012.3.issue-2/j.sjpain.2011.11.007/j.sjpain.2011.11.007.xml [pii]
PST - epublish
SO  - Scand J Pain. 2012 Apr 1;3(2):84-89. doi: 10.1016/j.sjpain.2011.11.007.


PMID- 27170972
STAT- Publisher
DA  - 20160513
PB  - Canadian Agency for Drugs and Technologies in Health
CTI - CADTH Optimal Use Reports
DP  - 2012 Mar
BTI - Large Volumetric Infusion Pumps: Inventory Management and Usability Surveys
AB  - The objectives of this project are to collect information on the current
      inventory of large volumetric infusion pumps used in Canada and to understand
      nurses' perception of the usability of large volumetric infusion pumps in
      Canadian hospitals. The current study will also seek to identify possible trends 
      from previous surveys associated with the usability of infusion pumps. This study
      did not require research ethics approval by the Canadian Agency for Drugs and
      Technologies in Health (CADTH).
CI  - Copyright (c) 2012 CADTH.
LA  - eng
PT  - Review
PT  - Book
PL  - Ottawa (ON)
EDAT- 2016/05/13 06:00
MHDA- 2016/05/13 06:00
CDAT- 2016/05/13 06:00
AID - NBK361394 [bookaccession]


PMID- 26131541
STAT- Publisher
DA  - 20150703
ISBN- 9789241504744
PB  - World Health Organization
CTI - WHO Guidelines Approved by the Guidelines Review Committee
DP  - 2012 Dec
BTI - Prevention and Treatment of HIV and Other Sexually Transmitted Infections for Sex
      Workers in Low- and Middle-Income Countries: Recommendations for a Public Health 
      Approach
AB  - The objective of this document is to provide technical recommendations on
      effective interventions for the prevention and treatment of HIV and other
      sexually transmitted infections (STIs) among sex workers and their clients. These
      include evidence-based recommendations following the GRADE methodology as well as
      recommendations for good practice. Good practice recommendations are overarching 
      principles derived not from scientific evidence but from common sense, ethics and
      human rights principles. These recommendations did not go through a formal GRADE 
      process but should be strongly promoted in all interventions with sex workers.
      The technical recommendations are supported not only by scientific evidence but
      also the lived experience of sex workers around the world as expressed in the
      results of a community values and preferences survey and at the guideline
      consensus meeting.
CI  - Copyright (c) World Health Organization 2012.
LA  - eng
PT  - Review
PT  - Practice Guideline
PT  - Book
PL  - Geneva
EDAT- 2015/07/03 06:00
MHDA- 2015/07/03 06:00
CDAT- 2015/07/03 06:00
AID - NBK304116 [bookaccession]


PMID- 25278651
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141003
LR  - 20211021
IS  - 0972-2068 (Print)
IS  - 0973-9793 (Linking)
VI  - 76
IP  - 4
DP  - 2014 Aug
TI  - A comparative study of paediatric thermal burns treated with topical heparin and 
      without heparin.
PG  - 282-7
LID - 10.1007/s12262-012-0674-6 [doi]
AB  - Following reports of heparin use in burn treatment, an ethics-committee-approved 
      prospective randomized study with controls compared results obtained using
      traditional usual burn treatment without heparin with results in similar patients
      similarly treated with heparin added topically. The subjects were 100 consecutive
      burn patients (age <15 years) with second-degree superficial and deep burns of
      5-45 % total body surface area size. Two largely similar cohort groups-a control 
      group (C) and a heparin group (H) with 50 subjects per group-were randomly
      treated. The 50 control group patients received traditional routine treatment,
      including topical antimicrobial cream, debridement, and, when needed, skin grafts
      in the early postburn period. The 50 heparin group patients, without topical
      cream, were additionally treated, starting on day 1 postburn, with 200 IU/ml
      sodium aqueous heparin solution USP (heparin) dripped on the burn surfaces and
      inserted into the blisters two to four times a day for 1-2 days, and then only on
      burn surfaces for a total of 5-7 days, before skin grafting, when needed.
      Thereafter, control and heparin group treatment was similar. It was found that
      the heparin patients complained of less pain and received less pain medicine than
      the control patients. The heparin group needed fewer dressings and oral
      antibiotics than the control group. The 50 heparin group patients had 4 skin
      graftings (8 %), while the 50 control group patients had 10 (20 %). Five control 
      group patients died (mortality 10 %). No heparin group patients died. The number 
      of days in hospital for the heparin group versus control group was significantly 
      less (overall P < 0.0001): 58 % of heparin group patients were discharged within 
      10 days versus 6 % of control group patients; 82 % of heparin group patients were
      out in 20 days versus 14 % of control group patients; 98 % of the heparin group
      versus 44 % of the control group were out in 30 days; and while 100 % of heparin 
      group patients were discharged by day 40, 56 % of the control group required up
      to another 10 days. Burns in heparin group patients healed on average in 15 days 
      (maximum period 37 days) versus an average of 25 days (maximum >48 days) in
      control group patients (P < 0.0006). Procedures and costs in the heparin group
      were much reduced compared with the control group. Differences between the
      heparin and control groups are presented for the sake of comparison. It was
      concluded that heparin applied topically for 5-7 days improved burn treatment: it
      reduced pain, pain medicine, dressings, and use of antibiotics; it significantly 
      reduced IV fluids (P < 0.04), days in hospital (P < 0.0001), and healing time (P 
      < 0.0006); and it reduced skin grafts, mortality, and costs.
FAU - Venkatachalapathy, T S
AU  - Venkatachalapathy TS
AD  - Indira Gandhi Govt General Hospital and Post Graduate Institute, Puducherry,
      India.
LA  - eng
PT  - Journal Article
DEP - 20121005
PL  - India
TA  - Indian J Surg
JT  - The Indian journal of surgery
JID - 0373026
PMC - PMC4175678
OTO - NOTNLM
OT  - IInd degree burns
OT  - Thermal burns
OT  - Topical heparin
EDAT- 2014/10/04 06:00
MHDA- 2014/10/04 06:01
CRDT- 2014/10/04 06:00
PHST- 2011/08/30 00:00 [received]
PHST- 2012/06/21 00:00 [accepted]
PHST- 2014/10/04 06:00 [entrez]
PHST- 2014/10/04 06:00 [pubmed]
PHST- 2014/10/04 06:01 [medline]
AID - 10.1007/s12262-012-0674-6 [doi]
AID - 674 [pii]
PST - ppublish
SO  - Indian J Surg. 2014 Aug;76(4):282-7. doi: 10.1007/s12262-012-0674-6. Epub 2012
      Oct 5.


PMID- 25059416
OWN - NLM
STAT- MEDLINE
DCOM- 20151015
LR  - 20140725
IS  - 1752-0606 (Electronic)
IS  - 0194-472X (Linking)
VI  - 40
IP  - 1
DP  - 2014 Jan
TI  - Navigating dual relationships in rural communities.
PG  - 125-36
LID - 10.1111/j.1752-0606.2012.00335.x [doi]
AB  - The literature examining dual relationships in rural communities is limited, and 
      existing ethical guidelines lack guidelines about how to navigate these complex
      relationships. This study uses grounded theory to explore rural therapists'
      perceptions of dual relationship issues, the perceived impact of minority and/or 
      religious affiliation on the likelihood of dual relationships, and the ways rural
      therapists handle inevitable dual relationship situations. All of the therapists 
      who participated in the study practiced in small communities and encountered dual
      relationship situations with regularity. The overarching theme that emerged from 
      the data was that of using professional judgment in engaging in the relationship,
      despite the fact that impairment of professional judgment is the main objection
      to dual relationships. This overall theme contained three areas where
      participants felt they most needed to use their judgment: the level of benefit or
      detriment to the client, the context, and the nature of the dual relationship.
      Surprisingly, supervision and/or consultation were not mentioned by the
      participants as strategies for handling dual relationships. The results of this
      study are compared with established ethical decision-making models, and
      implications for the ethical guidelines and appropriate ethical training are
      suggested.
CI  - (c) 2012 American Association for Marriage and Family Therapy.
FAU - Gonyea, Jennifer L J
AU  - Gonyea JL
AD  - The University of Georgia.
FAU - Wright, David W
AU  - Wright DW
FAU - Earl-Kulkosky, Terri
AU  - Earl-Kulkosky T
LA  - eng
PT  - Journal Article
DEP - 20120908
PL  - United States
TA  - J Marital Fam Ther
JT  - Journal of marital and family therapy
JID - 7904614
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Decision Making/ethics
MH  - Humans
MH  - Interviews as Topic
MH  - Minority Groups
MH  - Models, Theoretical
MH  - Professional-Patient Relations/*ethics
MH  - Psychotherapy/*ethics
MH  - *Rural Population
EDAT- 2014/07/26 06:00
MHDA- 2015/10/16 06:00
CRDT- 2014/07/26 06:00
PHST- 2014/07/26 06:00 [entrez]
PHST- 2014/07/26 06:00 [pubmed]
PHST- 2015/10/16 06:00 [medline]
AID - 10.1111/j.1752-0606.2012.00335.x [doi]
PST - ppublish
SO  - J Marital Fam Ther. 2014 Jan;40(1):125-36. doi: 10.1111/j.1752-0606.2012.00335.x.
      Epub 2012 Sep 8.


PMID- 25059296
OWN - NLM
STAT- MEDLINE
DCOM- 20150417
LR  - 20191210
IS  - 1752-0606 (Electronic)
IS  - 0194-472X (Linking)
VI  - 39
IP  - 3
DP  - 2013 Jul
TI  - Do therapists address gender and power in infidelity? A feminist analysis of the 
      treatment literature.
PG  - 271-84
LID - 10.1111/j.1752-0606.2012.00303.x [doi]
AB  - Sociocontextual factors such as gender and power play an important role in the
      etiology of affairs and in recovery from them, yet it is unclear how current
      treatment models address these issues. Drawing on feminist epistemology, this
      study utilized a grounded theory analysis of 29 scholarly articles and books on
      infidelity treatment published between 2000 and 2010 to identify the
      circumstances under which gender and power issues were or were not part of
      treatment. We found five conditions that limit attention to gender and power: (a)
      speaking (or assuming) as though partners are equal, (b) reframing infidelity as 
      a relationship problem, (c) limiting discussion of societal context to
      background, (d) not considering how societal gender and power patterns impact
      relationship dynamics, and (e) limiting discussion of ethics on how to position
      around infidelity. Analysis explored how each occurred across three phases of
      couple therapy. The findings provide a useful foundation for a sociocontextual
      framework for infidelity treatment.
CI  - (c) 2012 American Association for Marriage and Family Therapy.
FAU - Williams, Kirstee
AU  - Williams K
AD  - Loma Linda University.
FAU - Knudson-Martin, Carmen
AU  - Knudson-Martin C
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20120503
PL  - United States
TA  - J Marital Fam Ther
JT  - Journal of marital and family therapy
JID - 7904614
SB  - IM
MH  - Adult
MH  - Couples Therapy/*standards
MH  - Extramarital Relations/*psychology
MH  - Female
MH  - Feminism
MH  - Humans
MH  - Male
MH  - Men/*psychology
MH  - *Power, Psychological
MH  - Spouses/*psychology
MH  - Women/*psychology
EDAT- 2014/07/26 06:00
MHDA- 2015/04/18 06:00
CRDT- 2014/07/26 06:00
PHST- 2014/07/26 06:00 [entrez]
PHST- 2014/07/26 06:00 [pubmed]
PHST- 2015/04/18 06:00 [medline]
AID - 10.1111/j.1752-0606.2012.00303.x [doi]
PST - ppublish
SO  - J Marital Fam Ther. 2013 Jul;39(3):271-84. doi: 10.1111/j.1752-0606.2012.00303.x.
      Epub 2012 May 3.


PMID- 24830057
STAT- Publisher
DA  - 20140516
PB  - National Academies Press (US)
DP  - 2012 Mar 21
BTI - Crisis Standards of Care: A Systems Framework for Catastrophic Disaster Response
AB  - Catastrophic disasters occurring in 2011 in the United States and worldwide--from
      the tornado in Joplin, Missouri, to the earthquake and tsunami in Japan, to the
      earthquake in New Zealand--have demonstrated that even prepared communities can
      be overwhelmed. In 2009, at the height of the influenza A (H1N1) pandemic, the
      Assistant Secretary for Preparedness and Response at the Department of Health and
      Human Services, along with the Department of Veterans Affairs and the National
      Highway Traffic Safety Administration, asked the Institute of Medicine (IOM) to
      convene a committee of experts to develop national guidance for use by state and 
      local public health officials and health-sector agencies and institutions in
      establishing and implementing standards of care that should apply in disaster
      situations-both naturally occurring and man-made-under conditions of scarce
      resources. Building on the work of phase one (which is described in IOM's 2009
      letter report, Guidance for Establishing Crisis Standards of Care for Use in
      Disaster Situations), the committee developed detailed templates enumerating the 
      functions and tasks of the key stakeholder groups involved in crisis standards of
      care (CSC) planning, implementation, and public engagement-state and local
      governments, emergency medical services (EMS), hospitals and acute care
      facilities, and out-of-hospital and alternate care systems. Crisis Standards of
      Care provides a framework for a systems approach to the development and
      implementation of CSC plans, and addresses the legal issues and the ethical,
      palliative care, and mental health issues that agencies and organizations at each
      level of a disaster response should address. Please note: this report is not
      intended to be a detailed guide to emergency preparedness or disaster response.
      What is described in this report is an extrapolation of existing incident
      management practices and principles. Crisis Standards of Care is a seven-volume
      set: Volume 1 provides an overview; Volume 2 pertains to state and local
      governments; Volume 3 pertains to emergency medical services; Volume 4 pertains
      to hospitals and acute care facilities; Volume 5 pertains to out-of-hospital care
      and alternate care systems; Volume 6 contains a public engagement toolkit; and
      Volume 7 contains appendixes with additional resources.
CI  - Copyright 2012 by the National Academy of Sciences. All rights reserved.
CN  - Committee on Guidance for Establishing Crisis Standards of Care for Use in
      Disaster Situations
CN  - Institute of Medicine
LA  - eng
PT  - Review
PT  - Book
PL  - Washington (DC)
EDAT- 2014/05/16 06:00
MHDA- 2014/05/16 06:00
CDAT- 2014/05/16 06:00
AID - NBK201063 [bookaccession]
AID - 10.17226/13351 [doi]


PMID- 24830050
STAT- Publisher
DA  - 20140516
ISBN- 9780309218139
ISBN- 0309218136
PB  - National Academies Press (US)
DP  - 2012 May 1
BTI - Ethical and Scientific Issues in Studying the Safety of Approved Drugs
AB  - An estimated 48 percent of the population takes at least one prescription drug in
      a given month. Drugs provide great benefits to society by saving or improving
      lives. Many drugs are also associated with side effects or adverse events, some
      serious and some discovered only after the drug is on the market. The discovery
      of new adverse events in the postmarketing setting is part of the normal natural 
      history of approved drugs, and timely identification and warning about drug risks
      are central to the mission of the Food and Drug Administration (FDA). Not all
      risks associated with a drug are known at the time of approval, because safety
      data are collected from studies that involve a relatively small number of human
      subjects during a relatively short period. Written in response to a request by
      the FDA, Ethical and Scientific Issues in Studying the Safety of Approved Drugs
      discusses ethical and informed consent issues in conducting studies in the
      postmarketing setting. It evaluates the strengths and weaknesses of various
      approaches to generate evidence about safety questions, and makes recommendations
      for appropriate followup studies and randomized clinical trials. The book
      provides guidance to the FDA on how it should factor in different kinds of
      evidence in its regulatory decisions. Ethical and Scientific Issues in Studying
      the Safety of Approved Drugs will be of interest to the pharmaceutical industry, 
      patient advocates, researchers, and consumer groups.
CI  - Copyright 2012 by the National Academy of Sciences. All rights reserved.
CN  - Committee on Ethical and Scientific Issues in Studying the Safety of Approved
      Drugs
CN  - Board on Population Health and Public Health Practice
CN  - Institute of Medicine
LA  - eng
PT  - Review
PT  - Book
PL  - Washington (DC)
EDAT- 2014/05/16 06:00
MHDA- 2014/05/16 06:00
CDAT- 2014/05/16 06:00
AID - NBK200905 [bookaccession]
AID - 10.17226/13219 [doi]


PMID- 24809238
OWN - NLM
STAT- MEDLINE
DCOM- 20160418
LR  - 20140509
IS  - 1365-2834 (Electronic)
IS  - 0966-0429 (Linking)
VI  - 22
IP  - 4
DP  - 2014 May
TI  - Policy-makers' views on impact of specialist and advanced practitioner roles in
      Ireland: the SCAPE study.
PG  - 410-22
LID - 10.1111/jonm.12018 [doi]
AB  - AIM: To ascertain and explore the views held by key healthcare policy-makers on
      the impact of clinical specialist and advanced practice nursing and midwifery
      roles. BACKGROUND: Specialist and advanced practice roles are common world-wide
      and were introduced in Ireland in 2000. After experiencing these roles for a
      decade, the views of healthcare policy-makers were sought as part of a national
      evaluation. METHODS: A qualitative, descriptive design was used. Following
      ethical approval, 12 policy-makers were interviewed in 2010, using a six-part
      interview schedule. RESULTS: Policy-makers believed that specialist and advanced 
      practice roles resulted in better continuity of care, improved patient/client
      outcomes and a more holistic approach. These clinicians were also said to be
      leading guideline development, new initiatives in care, education of staff, audit
      and policy development. They lacked administrative support and research time.
      Budget cuts and a government-applied recruitment moratorium were said to hamper
      the development of specialist/advanced practice roles. CONCLUSION: Healthcare
      policy-makers believe that specialists and advanced practitioners contribute to
      higher quality patient/client care, particularly at a strategic level.
      IMPLICATIONS FOR NURSING MANAGEMENT: These roles could make an important
      contribution to future health service developments, particularly in relation to
      chronic-disease management and community care, where more advanced practitioner
      posts are required.
CI  - (c) 2012 John Wiley & Sons Ltd.
FAU - Begley, Cecily
AU  - Begley C
AD  - School of Nursing and Midwifery, Trinity College Dublin, Dublin.
FAU - Murphy, Kathy
AU  - Murphy K
FAU - Higgins, Agnes
AU  - Higgins A
FAU - Cooney, Adeline
AU  - Cooney A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121201
PL  - England
TA  - J Nurs Manag
JT  - Journal of nursing management
JID - 9306050
MH  - *Administrative Personnel
MH  - Attitude of Health Personnel
MH  - Humans
MH  - Interviews as Topic
MH  - Ireland
MH  - Leadership
MH  - *Nurse Clinicians/organization & administration
MH  - *Nurse Practitioners/organization & administration
MH  - *Nurse's Role
MH  - Qualitative Research
OTO - NOTNLM
OT  - advanced practice
OT  - clinical midwife specialist
OT  - clinical nurse specialist
OT  - nurse practitioners
OT  - qualitative research
EDAT- 2014/05/09 06:00
MHDA- 2016/04/19 06:00
CRDT- 2014/05/10 06:00
PHST- 2012/08/28 00:00 [accepted]
PHST- 2014/05/10 06:00 [entrez]
PHST- 2014/05/09 06:00 [pubmed]
PHST- 2016/04/19 06:00 [medline]
AID - 10.1111/jonm.12018 [doi]
PST - ppublish
SO  - J Nurs Manag. 2014 May;22(4):410-22. doi: 10.1111/jonm.12018. Epub 2012 Dec 1.


PMID- 24599815
OWN - NLM
STAT- MEDLINE
DCOM- 20141106
LR  - 20140306
IS  - 1741-2684 (Electronic)
IS  - 1471-3012 (Linking)
VI  - 13
IP  - 2
DP  - 2014 Mar 1
TI  - Electronic tracking for people with dementia: an exploratory study of the ethical
      issues experienced by carers in making decisions about usage.
PG  - 216-32
LID - 10.1177/1471301212460445 [doi]
AB  - Electronic tracking through GPS (global positioning system) is being used to
      monitor and locate people with dementia who are vulnerable to becoming lost.
      Through a review of the literature and an original study, this article examined
      ethical issues associated with use in a domestic setting. The qualitative study
      consisted of in-depth interviews with 10 carers who were using electronic
      tracking. The study explored the values, beliefs and contextual factors that
      motivated carers to use electronic tracking. It examined the extent of
      involvement of the person with dementia in decision-making and it explored the
      various ethical dilemmas encountered by carers when introducing the tracking
      system. As an issue that emerged from the interviews, specific attention was paid
      to exploring covert usage. From the study findings, recommendations have been
      made for research and practice about the use of electronic tracking in dementia
      care.
FAU - White, Eleanor Bantry
AU  - White EB
AD  - University College, Cork, Ireland.
FAU - Montgomery, Paul
AU  - Montgomery P
LA  - eng
PT  - Journal Article
DEP - 20121003
PL  - England
TA  - Dementia (London)
JT  - Dementia (London, England)
JID - 101128698
SB  - IM
MH  - Caregivers/*ethics/psychology
MH  - *Decision Making
MH  - Dementia/*psychology
MH  - Geographic Information Systems/*ethics
MH  - Humans
MH  - Privacy
OTO - NOTNLM
OT  - dementia
OT  - electronic tracking
OT  - ethical acceptability
OT  - wandering
EDAT- 2014/03/07 06:00
MHDA- 2014/11/07 06:00
CRDT- 2014/03/07 06:00
PHST- 2014/03/07 06:00 [entrez]
PHST- 2014/03/07 06:00 [pubmed]
PHST- 2014/11/07 06:00 [medline]
AID - 1471301212460445 [pii]
AID - 10.1177/1471301212460445 [doi]
PST - ppublish
SO  - Dementia (London). 2014 Mar 1;13(2):216-32. doi: 10.1177/1471301212460445. Epub
      2012 Oct 3.


PMID- 24533496
OWN - NLM
STAT- MEDLINE
DCOM- 20141006
LR  - 20151119
IS  - 1536-7290 (Electronic)
IS  - 1536-7290 (Linking)
VI  - 14
IP  - 1
DP  - 2014
TI  - Investigating eating disorders in elite gymnasts: conceptual, ethical and
      methodological issues.
PG  - 60-8
LID - 10.1080/17461391.2012.728632 [doi]
AB  - Elite gymnastics, and other sports where athletes and coaches are particularly
      concerned with aesthetic considerations, weight and shape, are fields within
      which the risk of eating disorders may be unusually high. Adolescent gymnasts,
      developing their own sense of self, at a time of life where body image concerns
      are common, often compete at the very top of the sport with a need to maintain a 
      body shape and weight optimal for elite performance. Research into this field
      should address the range of sociological and ethical aspects of eating disorders 
      in elite sport, their prevalence as well as the ethos of the sport itself. This
      paper addresses a range of conceptual, ethical and methodological issues relevant
      to conducting research in this sensitive yet important field.
FAU - Tan, Jacinta
AU  - Tan J
AD  - a College of Human and Health Sciences , Swansea University , Swansea , UK.
FAU - Bloodworth, Andrew
AU  - Bloodworth A
FAU - McNamee, Mike
AU  - McNamee M
FAU - Hewitt, Jeanette
AU  - Hewitt J
LA  - eng
PT  - Journal Article
DEP - 20121015
PL  - England
TA  - Eur J Sport Sci
JT  - European journal of sport science
JID - 101146739
SB  - IM
MH  - Adolescent
MH  - Athletes
MH  - *Athletic Performance/psychology
MH  - *Body Image
MH  - *Body Weight
MH  - *Competitive Behavior/ethics
MH  - Esthetics
MH  - Feeding and Eating Disorders/epidemiology/*etiology/psychology
MH  - *Gymnastics/ethics/psychology
MH  - Humans
MH  - Prevalence
MH  - Risk Factors
EDAT- 2014/02/19 06:00
MHDA- 2014/10/07 06:00
CRDT- 2014/02/19 06:00
PHST- 2014/02/19 06:00 [entrez]
PHST- 2014/02/19 06:00 [pubmed]
PHST- 2014/10/07 06:00 [medline]
AID - 10.1080/17461391.2012.728632 [doi]
PST - ppublish
SO  - Eur J Sport Sci. 2014;14(1):60-8. doi: 10.1080/17461391.2012.728632. Epub 2012
      Oct 15.


PMID- 24532934
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20211021
IS  - 0377-1237 (Print)
IS  - 0377-1237 (Linking)
VI  - 69
IP  - 1
DP  - 2013 Jan
TI  - End of life issues in the intensive care units.
PG  - 48-53
LID - 10.1016/j.mjafi.2012.03.009 [doi]
AB  - A structured discussion of End-of-Life (EOL) issues is a relatively new
      phenomenon in India. Personal beliefs, cultural and religious influences, peer,
      family and societal pressures affect EOL decisions. Indian law does not provide
      sanction to contentious issues such as do-not-resuscitate (DNR) orders, living
      wills, and euthanasia. Finally, published data on EOL decisions in Indian ICUs is
      lacking. What is needed is a prospective determination of which patients will
      benefit from aggressive management and life-support. A consensus regarding the
      concept of Medical Futility is necessary to give impetus to further discussion on
      more advanced policies including ideas such as Managed Care to restrict
      unnecessary health care costs, euthanasia, the principle of withhold and/or
      withdraw, ethical and moral guidelines that would govern decisions regarding
      futile treatment, informed consent to EOL decisions and do-not-resuscitate
      orders. This review examines the above concepts as practiced worldwide and looks 
      at some landmark judgments that have shaped current Indian policy, as well as
      raising talking points for possible legislative intervention in the field.
FAU - Datta, Rashmi
AU  - Datta R
AD  - Senior Advisor, Anaesthesiology, Army Hospital (R&R), New Delhi, India.
FAU - Chaturvedi, R
AU  - Chaturvedi R
AD  - Dean & Deputy Commandant, CH (AF), Bangalore 560 007, India.
FAU - Rudra, A
AU  - Rudra A
AD  - Commanding Officer, 408 Field Hospital, C/o 56 APO, India.
FAU - Jaideep, C N
AU  - Jaideep CN
AD  - Associate Professor, Anaesthesiology, AFMC, Pune 40, India.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121023
PL  - India
TA  - Med J Armed Forces India
JT  - Medical journal, Armed Forces India
JID - 7602492
PMC - PMC3862790
OTO - NOTNLM
OT  - Do-not-Resuscitate Orders
OT  - End of life
OT  - Intensive care unit
OT  - Medical Futility
EDAT- 2014/02/18 06:00
MHDA- 2014/02/18 06:01
CRDT- 2014/02/18 06:00
PHST- 2010/08/28 00:00 [received]
PHST- 2012/03/23 00:00 [accepted]
PHST- 2014/02/18 06:00 [entrez]
PHST- 2014/02/18 06:00 [pubmed]
PHST- 2014/02/18 06:01 [medline]
AID - 10.1016/j.mjafi.2012.03.009 [doi]
AID - S0377-1237(12)00163-3 [pii]
PST - ppublish
SO  - Med J Armed Forces India. 2013 Jan;69(1):48-53. doi: 10.1016/j.mjafi.2012.03.009.
      Epub 2012 Oct 23.


PMID- 24444202
OWN - NLM
STAT- MEDLINE
DCOM- 20140924
LR  - 20140121
IS  - 1536-7290 (Electronic)
IS  - 1536-7290 (Linking)
VI  - 14 Suppl 1
DP  - 2014
TI  - Anthropometric variables and their relationship to performance and ability in
      male surfers.
PG  - S171-7
LID - 10.1080/17461391.2012.666268 [doi]
AB  - Abstract The aim of this study was to evaluate the anthropometric profiles of
      male surfers and to investigate the relationship of these measures with
      performance and ability. Following institutional ethical approval, 79 male
      surfers underwent anthropometric assessment. These surfers composed of three
      sub-groups of professional (n=17; age: 34.12, s =3.81 years, stature: 177.28, s
      =6.29 cm; body mass: 78.57, s =7.17 kg), junior national level (n=15; age: 15.61,
      s =1.06 years, stature: 173.86, s =5.72 cm; body mass: 63.27, s =7.17 kg) and
      intermediate level surfers (n=47; age: 22.47, s =2.80 years, stature: 179.90, s
      =5.41; body mass: 77.83, s =9.43 kg). The mean somatotype values for the
      different groups of surfers were found to be 2.48, 5.00 and 1.03 for the
      professional surfers; 2.18, 3.72 and 3.24 for the junior national surfers and
      2.79, 3.57 and 2.42 for the intermediate surfers. Professional surfers were
      significantly (P < 0.01) more mesomorphic and less ectomorphic than intermediate 
      level surfers. Significant correlations were observed between endomorphy (r =
      -0.399, P < 0.01), sum of six skinfolds (r = -0.341, P < 0.05), and body fat
      percentage (r = -0.380, P < 0.01) and the rating of ability among the
      intermediate group of surfers. Across all participants, the rating of surfer
      ability was significantly correlated with endomorphy (r = -0.366, P </= 0.01),
      mesomorphy (r = 0.442, P < 0.01), sum of six skinfolds (r = -0.274, P < 0.05) and
      body fat percentage (r = -0.268, P < 0.05). Findings suggest that the levels of
      adiposity and muscularity may influence the potential for progression between
      intermediate and professional-level surfing performance.
FAU - Barlow, Matthew John
AU  - Barlow MJ
AD  - a Faculty of Science , Plymouth University , Plymouth , UK.
FAU - Findlay, Malcolm
AU  - Findlay M
FAU - Gresty, Karen
AU  - Gresty K
FAU - Cooke, Carlton
AU  - Cooke C
LA  - eng
PT  - Journal Article
DEP - 20120319
PL  - England
TA  - Eur J Sport Sci
JT  - European journal of sport science
JID - 101146739
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Athletes
MH  - Athletic Performance/*physiology
MH  - Body Composition/*physiology
MH  - Humans
MH  - Male
MH  - Somatotypes/*physiology
MH  - Sports/*physiology
MH  - Young Adult
EDAT- 2014/01/22 06:00
MHDA- 2014/09/25 06:00
CRDT- 2014/01/22 06:00
PHST- 2014/01/22 06:00 [entrez]
PHST- 2014/01/22 06:00 [pubmed]
PHST- 2014/09/25 06:00 [medline]
AID - 10.1080/17461391.2012.666268 [doi]
PST - ppublish
SO  - Eur J Sport Sci. 2014;14 Suppl 1:S171-7. doi: 10.1080/17461391.2012.666268. Epub 
      2012 Mar 19.


PMID- 24431807
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140116
LR  - 20220331
IS  - 0972-8279 (Print)
IS  - 0972-8270 (Linking)
VI  - 12
IP  - 1
DP  - 2013 Mar
TI  - Bone regeneration in extraction sockets with autologous platelet rich fibrin gel.
PG  - 11-6
LID - 10.1007/s12663-012-0370-x [doi]
AB  - AIM: To evaluate the effects of autologous platelet rich fibrin gel (PRF gel) on 
      bone regeneration following extraction. MATERIALS AND METHODS: The study design
      was approved by the Institutional Ethical Committee. Study sample consisting of a
      total of 22 patients requiring bilateral transalveolar third molar extractions
      were included after written informed consent. One side was randomly chosen as
      case and the other side was the control. Autologous PRF gel was prepared from
      Fresh blood obtained from the patient. The PRF gel was placed in the extraction
      site and primary closure was obtained. The patient was called for a follow up on 
      the first post op day, 1st week, one month, three month and six months post op.
      Regeneration of bone was measured using serial radiographs (RVG) at immediate
      post op, one, three and six months. This was then compared with the bone
      regeneration seen in the control group, with the radiographs taken at same
      intervals, to estimate the difference in bone regeneration if any. RVGs were
      assessed for amount of radiologic bone filling by the method described by Matteo 
      Chiapasco et al. RESULTS AND CONCLUSION: Higher mean pixels was recorded in cases
      compared to controls at all the time intervals viz., immediate post op, 1 month
      post op, 3 months post op and 6 months post op. However, the difference in the
      mean pixels recorded between the two groups was not statistically significant (P 
      > 0.05). For complete analysis, further follow up of the present patients and a
      larger sample size is required to obtain a conclusive result of the Bone
      Regeneration in extraction sockets with PRF gel.
FAU - Girish Rao, S
AU  - Girish Rao S
AD  - Department of Oral and Maxillofacial Surgery, DAPMRV Dental College & Hospital,
      Bangalore, 560078 India.
FAU - Bhat, Preethi
AU  - Bhat P
AD  - Department of Oral and Maxillofacial Surgery, DAPMRV Dental College & Hospital,
      Bangalore, 560078 India.
FAU - Nagesh, K S
AU  - Nagesh KS
AD  - Department of Oral Medicine and Radiology, DAPMRV Dental College & Hospital,
      Bangalore, 560078 India.
FAU - Rao, Gundu H R
AU  - Rao GH
AD  - Department of Biomedical Engineering Institute, University of Minnesota,
      Minneapolis, MN USA.
FAU - Mirle, Bharthi
AU  - Mirle B
AD  - Department of Pathology, DAPMRV Dental College & Hospital, Bangalore, 560078
      India.
FAU - Kharbhari, Lubna
AU  - Kharbhari L
AD  - Department of Oral and Maxillofacial Surgery, DAPMRV Dental College & Hospital,
      Bangalore, 560078 India.
FAU - Gangaprasad, B
AU  - Gangaprasad B
AD  - Department of Oral and Maxillofacial Surgery, DAPMRV Dental College & Hospital,
      Bangalore, 560078 India.
LA  - eng
PT  - Journal Article
DEP - 20120510
PL  - India
TA  - J Maxillofac Oral Surg
JT  - Journal of maxillofacial and oral surgery
JID - 101538309
PMC - PMC3589514
OTO - NOTNLM
OT  - Bone regeneration
OT  - Platelet gel
OT  - Platelet rich fibrin
OT  - Post extraction socket
EDAT- 2014/01/17 06:00
MHDA- 2014/01/17 06:01
CRDT- 2014/01/17 06:00
PHST- 2012/01/13 00:00 [received]
PHST- 2012/03/05 00:00 [accepted]
PHST- 2014/01/17 06:00 [entrez]
PHST- 2014/01/17 06:00 [pubmed]
PHST- 2014/01/17 06:01 [medline]
AID - 10.1007/s12663-012-0370-x [doi]
AID - 370 [pii]
PST - ppublish
SO  - J Maxillofac Oral Surg. 2013 Mar;12(1):11-6. doi: 10.1007/s12663-012-0370-x. Epub
      2012 May 10.


PMID- 24431767
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20211021
IS  - 0972-4052 (Print)
IS  - 0972-4052 (Linking)
VI  - 13
IP  - 4
DP  - 2013 Dec
TI  - Prosthodontic Management of HIV/AIDS Subjects: An Overview.
PG  - 393-9
LID - 10.1007/s13191-012-0232-8 [doi]
AB  - Provision for high standard of oral health care is a fundamental requirement for 
      any individual and dentists constantly strive to provide optimal treatment to
      their patients. However, when it comes to treating subjects with infectious
      diseases particularly those attached with social stigma like HIV/AIDS, there
      remains doubts and hesitations. This may lead the practitioners to breach the
      ethical responsibility by denying or not providing adequate treatment to these
      patients. Such situations can easily be avoided with thorough knowledge and
      awareness among the oral health care providers including prosthodontists
      regarding the disease process, its implications and measures to be taken during
      their treatment. This article summarises key points in prosthodontic management
      of HIV/AIDS patients which in the opinion of the author may be easily
      incorporated in routine dental practice.
FAU - Nagaraj, K R
AU  - Nagaraj KR
AD  - Department of Prosthodontics, The Oxford Dental College and Hospital, Bangalore, 
      India.
FAU - Savadi, Ravindra
AU  - Savadi R
AD  - Department of Prosthodontics, The Oxford Dental College and Hospital, Bangalore, 
      India.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121220
PL  - India
TA  - J Indian Prosthodont Soc
JT  - Journal of Indian Prosthodontic Society
JID - 101255941
PMC - PMC3792319
OTO - NOTNLM
OT  - Candidiasis
OT  - Dentures
OT  - Oral health
OT  - Universal precautions
OT  - Xerostomia
EDAT- 2014/01/17 06:00
MHDA- 2014/01/17 06:01
CRDT- 2014/01/17 06:00
PHST- 2012/11/23 00:00 [received]
PHST- 2012/12/03 00:00 [accepted]
PHST- 2014/01/17 06:00 [entrez]
PHST- 2014/01/17 06:00 [pubmed]
PHST- 2014/01/17 06:01 [medline]
AID - 10.1007/s13191-012-0232-8 [doi]
AID - 232 [pii]
PST - ppublish
SO  - J Indian Prosthodont Soc. 2013 Dec;13(4):393-9. doi: 10.1007/s13191-012-0232-8.
      Epub 2012 Dec 20.


PMID- 24427708
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140115
LR  - 20211021
IS  - 2231-3796 (Print)
IS  - 2231-3796 (Linking)
VI  - 65
IP  - Suppl 3
DP  - 2013 Dec
TI  - The Correlation Between Pre and Postoperative Hearing Level with High Resolution 
      Computed Tomography (HRCT) Findings in Congenital Canal Atresia (CAA) Patients.
PG  - 526-31
LID - 10.1007/s12070-011-0438-9 [doi]
AB  - In managing patient with congenital congenital aural atresia (CAA), preoperative 
      high resolution computed tomography (HRCT) scan and hearing assessment are
      important. A grading system based on HRCT findings was first introduced by
      Jahrsdoefer in order to select appropriate candidates for operation and to
      predict the postoperative hearing outcome in CAA patients. The score of eight and
      more was considered as a good prognostic factor for hearing reconstruction
      surgery. However previously in our center this score was not used as the criteria
      for surgical procedure. This study was conducted at Center A to evaluate the
      correlation between pre and postoperative hearing level with HRCT based on a
      Jahrsdoefer grading system in patients with CAA. All records and HRCT films with 
      CAA from January 1997 until December 2007 at Center A were evaluated. The
      demographic data, operative records, pre and post operative hearing levels and
      HRCT findings were analyzed. Hearing level in this study was based on a pure tone
      average of air-bone gap at 500 Hz, 1 kHz and 2 kHz or hearing level obtained from
      auditory brainstem response eudiometry. This study was approved by Research
      Ethics Committee (code number, FF-197-2008). Thirty-two ears were retrospectively
      evaluated. The postoperative hearing level of 30 dB and less was considered as
      successful hearing result postoperatively. Of the six ears which underwent
      canalplasty, three had achieved successful hearing result. However, there was no 
      significant correlation between preoperative hearing level (HL) with HRCT score
      and postoperative HL with HRCT score at 0.05 significant levels (correlation
      coefficient = -0.292, P = 0.105 and correlation coefficient = -0.127, P = 0.810) 
      respectively. Hearing evaluation and HRCT temporal bone are two independent
      evaluations for the patients with CAA before going for hearing reconstructive
      surgery.
FAU - Asma, A
AU  - Asma A
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine,
      Universiti Kebangsaan Malaysia, Jalan Yaakub Latif, 56000 Cheras, Kuala Lumpur,
      Malaysia.
FAU - Abdul Fatah, A W
AU  - Abdul Fatah AW
AD  - Department of Otorhinolaryngology, Sungai Buloh Hospital, Sungai Buloh, Malaysia.
FAU - Hamzaini, A H
AU  - Hamzaini AH
AD  - Department of Radiology, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
FAU - Mazita, A
AU  - Mazita A
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine,
      Universiti Kebangsaan Malaysia, Jalan Yaakub Latif, 56000 Cheras, Kuala Lumpur,
      Malaysia.
LA  - eng
PT  - Journal Article
DEP - 20120110
PL  - India
TA  - Indian J Otolaryngol Head Neck Surg
JT  - Indian journal of otolaryngology and head and neck surgery : official publication
      of the Association of Otolaryngologists of India
JID - 9422551
PMC - PMC3889344
OTO - NOTNLM
OT  - Canal atresia
OT  - Canalplasty
OT  - High resolution computed tomography
OT  - Pure tone audiometry
OT  - Stapes
EDAT- 2014/01/16 06:00
MHDA- 2014/01/16 06:01
CRDT- 2014/01/16 06:00
PHST- 2010/06/28 00:00 [received]
PHST- 2011/12/20 00:00 [accepted]
PHST- 2014/01/16 06:00 [entrez]
PHST- 2014/01/16 06:00 [pubmed]
PHST- 2014/01/16 06:01 [medline]
AID - 10.1007/s12070-011-0438-9 [doi]
AID - 438 [pii]
PST - ppublish
SO  - Indian J Otolaryngol Head Neck Surg. 2013 Dec;65(Suppl 3):526-31. doi:
      10.1007/s12070-011-0438-9. Epub 2012 Jan 10.


PMID- 24426015
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20211021
IS  - 0022-1155 (Print)
IS  - 0022-1155 (Linking)
VI  - 50
IP  - 6
DP  - 2013 Dec
TI  - Genetically modified foods: safety, risks and public concerns-a review.
PG  - 1035-46
LID - 10.1007/s13197-012-0899-1 [doi]
AB  - Genetic modification is a special set of gene technology that alters the genetic 
      machinery of such living organisms as animals, plants or microorganisms.
      Combining genes from different organisms is known as recombinant DNA technology
      and the resulting organism is said to be 'Genetically modified (GM)',
      'Genetically engineered' or 'Transgenic'. The principal transgenic crops grown
      commercially in field are herbicide and insecticide resistant soybeans, corn,
      cotton and canola. Other crops grown commercially and/or field-tested are sweet
      potato resistant to a virus that could destroy most of the African harvest, rice 
      with increased iron and vitamins that may alleviate chronic malnutrition in Asian
      countries and a variety of plants that are able to survive weather extremes.
      There are bananas that produce human vaccines against infectious diseases such as
      hepatitis B, fish that mature more quickly, fruit and nut trees that yield years 
      earlier and plants that produce new plastics with unique properties. Technologies
      for genetically modifying foods offer dramatic promise for meeting some areas of 
      greatest challenge for the 21st century. Like all new technologies, they also
      pose some risks, both known and unknown. Controversies and public concern
      surrounding GM foods and crops commonly focus on human and environmental safety, 
      labelling and consumer choice, intellectual property rights, ethics, food
      security, poverty reduction and environmental conservation. With this new
      technology on gene manipulation what are the risks of "tampering with Mother
      Nature"?, what effects will this have on the environment?, what are the health
      concerns that consumers should be aware of? and is recombinant technology really 
      beneficial? This review will also address some major concerns about the safety,
      environmental and ecological risks and health hazards involved with GM foods and 
      recombinant technology.
FAU - Bawa, A S
AU  - Bawa AS
AD  - Defence Food Research Laboratory, Siddarthanagar, Mysore, 570011 India.
FAU - Anilakumar, K R
AU  - Anilakumar KR
AD  - Defence Food Research Laboratory, Siddarthanagar, Mysore, 570011 India.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121219
PL  - India
TA  - J Food Sci Technol
JT  - Journal of food science and technology
JID - 0056471
PMC - PMC3791249
OTO - NOTNLM
OT  - Allergenic foods
OT  - Food safety
OT  - Genetically engineered foods
OT  - Genetically modified foods
OT  - Public concerns
OT  - Transgenic foods
EDAT- 2014/01/16 06:00
MHDA- 2014/01/16 06:01
CRDT- 2014/01/16 06:00
PHST- 2012/11/16 00:00 [revised]
PHST- 2012/11/19 00:00 [accepted]
PHST- 2014/01/16 06:00 [entrez]
PHST- 2014/01/16 06:00 [pubmed]
PHST- 2014/01/16 06:01 [medline]
AID - 10.1007/s13197-012-0899-1 [doi]
AID - 899 [pii]
PST - ppublish
SO  - J Food Sci Technol. 2013 Dec;50(6):1035-46. doi: 10.1007/s13197-012-0899-1. Epub 
      2012 Dec 19.


PMID- 24265878
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131122
LR  - 20211021
IS  - 2061-1617 (Print)
IS  - 2061-1617 (Linking)
VI  - 4
IP  - 4
DP  - 2012 Dec
TI  - Forensic standardizations in torture and death in custody investigations.
PG  - 210-6
LID - 10.1556/IMAS.4.2012.4.6 [doi]
AB  - UNLABELLED: Torture and death in custody have incurred rapid development as
      juridical subject in recent years in Europe, with the implementation of the
      European Convention of Human Rights. Evaluation of sufferance severity, which is 
      the consequence of pathology with chronic evolution, the predictability of
      decompensation of a subclinical pathology, and translating these medical
      information on a scale measuring the severity of detention consequences, are all 
      challenges for the modern detention healthcare system, in which most allegations 
      of torture are due to lack of appropriate medical treatment administered to
      inmates. Where ethics are concerned, the main data difficulties are addressed in 
      ethical conflicts between officials and experts of the parties and also between
      experts and judiciary officials who handle cases of torture or death in
      detention; this is why standardization is very important in such cases both in
      clinical expertise and in autopsies or exhumations. DISCUSSIONS: We must improve 
      the forensic expertise methodology, the process of collecting data with
      statistical purposes, and sound evaluation criteria, all in a strong connection
      with the need for a balanced legal framework applied in the case of civil
      compensations granted after death in custody, and the biunique relation between
      medico-legal expertise and case investigation has to be standardized.
FAU - Stan, Cristian Adrian
AU  - Stan CA
LA  - eng
PT  - Journal Article
DEP - 20121227
PL  - Hungary
TA  - Interv Med Appl Sci
JT  - Interventional medicine & applied science
JID - 101539233
PMC - PMC3831788
OTO - NOTNLM
OT  - capacity of detention
OT  - civil compensations
OT  - death in custody
OT  - ethical conflicts
OT  - forensic standardizations
OT  - lack of adequate medical treatment
OT  - torture
EDAT- 2013/11/23 06:00
MHDA- 2013/11/23 06:01
CRDT- 2013/11/23 06:00
PHST- 2012/04/24 00:00 [received]
PHST- 2012/07/27 00:00 [accepted]
PHST- 2013/11/23 06:00 [entrez]
PHST- 2013/11/23 06:00 [pubmed]
PHST- 2013/11/23 06:01 [medline]
AID - 10.1556/IMAS.4.2012.4.6 [doi]
AID - IMAS_4(2012)4/6 [pii]
PST - ppublish
SO  - Interv Med Appl Sci. 2012 Dec;4(4):210-6. doi: 10.1556/IMAS.4.2012.4.6. Epub 2012
      Dec 27.


PMID- 24203917
OWN - NLM
STAT- MEDLINE
DCOM- 20140615
LR  - 20131108
IS  - 1542-9768 (Electronic)
IS  - 1542-975X (Linking)
VI  - 96
IP  - 4
DP  - 2012 Dec
TI  - Using natural disasters to study the effects of prenatal maternal stress on child
      health and development.
PG  - 273-88
LID - 10.1002/bdrc.21026 [doi]
AB  - Research on the developmental origins of health and disease highlights the
      plasticity of the human fetus to a host of potential teratogens. Experimental
      research on laboratory animals has demonstrated a variety of physical and
      behavioral effects among offspring exposed to prenatal maternal stress (PNMS).
      However, these studies cannot elucidate the relative effects of the objective
      stress exposure and the subjective distress in a way that would parallel the
      stress experience in humans. PNMS research with humans is also limited because
      there are ethical challenges to designing studies that involve the random
      assignment of pregnant women to varying levels of independent stressors. Natural 
      disasters present opportunities for natural experiments of the effects of
      pregnant women's exposure to stress on child development. In this review, we
      present an overview of the human and animal research on PNMS, and highlight the
      results of Project Ice Storm which has been following the cognitive, behavioral, 
      motor and physical development of children exposed in utero to the January 1998
      Quebec Ice Storm. We have found that both objective degree of exposure to the
      storm and the mothers' subjective distress have strong and persistent effects on 
      child development, and that these effects are often moderated by the timing of
      the ice storm in pregnancy and by the child's sex.
CI  - Copyright (c) 2013 Wiley Periodicals, Inc.
FAU - King, Suzanne
AU  - King S
AD  - Department of Psychiatry, McGill University, Montreal, Quebec, Canada; Douglas
      Hospital Research Centre, Psychosocial Research Division, Montreal, Quebec,
      Canada.
FAU - Dancause, Kelsey
AU  - Dancause K
FAU - Turcotte-Tremblay, Anne-Marie
AU  - Turcotte-Tremblay AM
FAU - Veru, Franz
AU  - Veru F
FAU - Laplante, David P
AU  - Laplante DP
LA  - eng
GR  - MOP-111177/Canadian Institutes of Health Research/Canada
GR  - MOP-57849/Canadian Institutes of Health Research/Canada
GR  - MOP-79424/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Birth Defects Res C Embryo Today
JT  - Birth defects research. Part C, Embryo today : reviews
JID - 101167665
SB  - IM
MH  - Body Mass Index
MH  - Child
MH  - Child Development/physiology
MH  - Child Welfare
MH  - Cognition/physiology
MH  - *Disasters
MH  - Female
MH  - Humans
MH  - Male
MH  - Obesity/metabolism
MH  - Pregnancy
MH  - Pregnancy Outcome
MH  - *Prenatal Exposure Delayed Effects
MH  - Quebec
MH  - *Stress, Physiological
OTO - NOTNLM
OT  - disaster research
OT  - newborn and child outcomes
OT  - prenatal maternal stress
EDAT- 2013/11/10 06:00
MHDA- 2014/06/16 06:00
CRDT- 2013/11/09 06:00
PHST- 2012/10/12 00:00 [received]
PHST- 2012/11/25 00:00 [accepted]
PHST- 2013/11/09 06:00 [entrez]
PHST- 2013/11/10 06:00 [pubmed]
PHST- 2014/06/16 06:00 [medline]
AID - 10.1002/bdrc.21026 [doi]
PST - ppublish
SO  - Birth Defects Res C Embryo Today. 2012 Dec;96(4):273-88. doi: 10.1002/bdrc.21026.


PMID- 24179585
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20211021
IS  - 1941-0921 (Electronic)
IS  - 1941-0921 (Linking)
VI  - 4
IP  - 6
DP  - 2012 Nov
TI  - Ethical issues in sports medicine: a review and justification for ethical
      decision making and reasoning.
PG  - 475-9
LID - 10.1177/1941738112459327 [doi]
AB  - Ethical issues present a challenge for health care professionals working with
      athletes of sports teams. Health care professionals-including the team physician,
      the physical therapist, and the athletic trainer-are faced with the challenge of 
      returning an athlete to competition as quickly as possible but as safely as
      possible. Conflicts of interest arise due to conflicting obligations of the team 
      physician to the athlete and other members of the sports organization, including 
      coaches and the team owner. The multiple stakeholders involved in sports teams
      challenge the traditional notion of confidentiality and autonomy. The aims of
      this article are to explicate the ethics of sports medicine, highlight the
      ethical issues, and provide some strategies and suggestions for ethical decision 
      making.
FAU - Greenfield, Bruce H
AU  - Greenfield BH
AD  - Division of Physical Therapy, Department of Rehabilitation Medicine, Emory
      University School of Medicine, Faculty Affiliate Center for Ethics, Emory
      University, Atlanta, Georgia.
FAU - West, Charles Robert
AU  - West CR
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Sports Health
JT  - Sports health
JID - 101518422
PMC - PMC3497948
OTO - NOTNLM
OT  - Ethical Issues
OT  - Ethics
OT  - Sports Medicine
OT  - ethical decision-making
EDAT- 2013/11/02 06:00
MHDA- 2013/11/02 06:01
CRDT- 2013/11/02 06:00
PHST- 2013/11/02 06:00 [entrez]
PHST- 2013/11/02 06:00 [pubmed]
PHST- 2013/11/02 06:01 [medline]
AID - 10.1177/1941738112459327 [doi]
AID - 10.1177_1941738112459327 [pii]
PST - ppublish
SO  - Sports Health. 2012 Nov;4(6):475-9. doi: 10.1177/1941738112459327.


PMID- 32847298
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200827
IS  - 1475-357X (Print)
IS  - 1475-357X (Linking)
VI  - 18
IP  - 4
DP  - 2013 Nov
TI  - Childhood sexual abuse: community-based treatment practices and predictors of use
      of evidence-based practices.
PG  - 240-246
LID - 10.1111/camh.12011 [doi]
AB  - BACKGROUND: Cognitive behavior therapy with abuse-focused components is
      empirically supported for children/adolescents who have experienced childhood
      sexual abuse (CSA). We examined the extent to which community-based psychologists
      use evidence-based practices (EBP) for CSA and identified predictors of EBP use. 
      METHOD: Psychologists (N = 231) providing CSA treatment services to
      children/adolescents in Ontario (Canada) were identified through the first census
      of child and adolescent psychology clinicians registered with the College of
      Psychologists of Ontario. Participants completed a questionnaire on treatment
      strategies, sociodemographics, work setting, treatment provision, and attitudes
      toward EBP. Data were collected between December 2009 and June 2010. RESULTS: The
      majority (78%) of psychologists providing CSA services reported never having
      received training in specific treatment approaches for this population. Only 5%
      of psychologists received training in the EBP of trauma-focused cognitive
      behavior therapy. Multiple regressions indicated that age, theoretical
      orientation, continuing education, and attitudes predicted the use of an
      empirically based intervention for CSA. CONCLUSION: Study findings show that few 
      community-based psychologists have received training in specific treatment
      approaches for CSA victims and very few are trained to deliver EBP for this
      population. There are ethical concerns about the practice of psychologists who
      are untrained and unsupervised doing this work. Research findings, which
      underline the need for training, supervision, and continuing education, need to
      be translated into clinical practice.
CI  - (c) 2012 The Authors. Child and Adolescent Mental Health. (c) 2012 Association
      for Child and Adolescent Mental Health.
FAU - Czincz, Jennifer
AU  - Czincz J
AD  - School of Psychology, University of Ottawa, Vanier Hall, 136 Jean Jacques
      Lussier, Ottawa, ON, K1N 6N5, Canada.
FAU - Romano, Elisa
AU  - Romano E
AD  - University of Ottawa, Ottawa, ON, Canada.
LA  - eng
PT  - Journal Article
DEP - 20121203
PL  - England
TA  - Child Adolesc Ment Health
JT  - Child and adolescent mental health
JID - 101142157
SB  - IM
OTO - NOTNLM
OT  - Sexual abuse
OT  - adolescents
OT  - children
OT  - dissemination
OT  - empirically supported intervention
EDAT- 2013/11/01 00:00
MHDA- 2013/11/01 00:01
CRDT- 2020/08/28 06:00
PHST- 2012/09/11 00:00 [accepted]
PHST- 2020/08/28 06:00 [entrez]
PHST- 2013/11/01 00:00 [pubmed]
PHST- 2013/11/01 00:01 [medline]
AID - 10.1111/camh.12011 [doi]
PST - ppublish
SO  - Child Adolesc Ment Health. 2013 Nov;18(4):240-246. doi: 10.1111/camh.12011. Epub 
      2012 Dec 3.


PMID- 24083120
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131001
LR  - 20211021
IS  - 2193-6331 (Print)
IS  - 2193-634X (Linking)
VI  - 73
IP  - 5
DP  - 2012 Oct
TI  - New dried human amniotic membrane is useful as a substitute for dural repair
      after skull base surgery.
PG  - 302-7
LID - 10.1055/s-0032-1321506 [doi]
AB  - Objectives Cerebrospinal fluid (CSF) leakage is an undesirable complication of
      skull base surgery. We used dried human amniotic membrane (AM) as a patch graft
      for dural repair to determine its efficacy in preventing CSF leakage. Design
      Frontoparietal craniotomy and removal of dura were performed in 20 Wistar rats. A
      dried AM was placed to cover the dural defect without suturing in 16 animals. In 
      four animals, an expanded polytetrafluoroethylene was implanted. At 2 weeks and
      1, 3, and 6 months, histological examination was performed. Dried AM was also
      used as a substitute in 10 patients who underwent skull base surgery, after
      approval by the Ethics Committee of the University of Toyama. Results At 2 weeks 
      after implantation, thick connective tissue completely enclosed the dried AM. At 
      1 month after implantation, the connective tissue became thin and the implanted
      AM shortened. At 3 and 6 months after implantation, histological examination
      revealed disappearance of the dried AM and formation of membranous tissue. In the
      clinical study, neither CSF leakage nor clinical adverse reactions directly
      related to the dried AM were observed. Conclusion Dried human AM appears to be an
      ideal substitute for dura, since it is replaced by natural tissue.
FAU - Tomita, Takahiro
AU  - Tomita T
AD  - Departments of Neurosurgery, University of Toyama Graduate School of Medicine and
      Pharmaceutical Sciences, Toyama, Japan.
FAU - Hayashi, Nakamasa
AU  - Hayashi N
FAU - Okabe, Motonori
AU  - Okabe M
FAU - Yoshida, Toshiko
AU  - Yoshida T
FAU - Hamada, Hideo
AU  - Hamada H
FAU - Endo, Shunro
AU  - Endo S
FAU - Nikaido, Toshio
AU  - Nikaido T
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - J Neurol Surg B Skull Base
JT  - Journal of neurological surgery. Part B, Skull base
JID - 101580780
PMC - PMC3578633
OTO - NOTNLM
OT  - amniotic membrane
OT  - cerebrospinal fluid (CSF) leakage
OT  - dural repair
OT  - dural substitute
OT  - skull base surgery
EDAT- 2013/10/02 06:00
MHDA- 2013/10/02 06:01
CRDT- 2013/10/02 06:00
PHST- 2011/01/12 00:00 [received]
PHST- 2011/04/25 00:00 [accepted]
PHST- 2013/10/02 06:00 [entrez]
PHST- 2013/10/02 06:00 [pubmed]
PHST- 2013/10/02 06:01 [medline]
AID - 10.1055/s-0032-1321506 [doi]
AID - 73302 [pii]
PST - ppublish
SO  - J Neurol Surg B Skull Base. 2012 Oct;73(5):302-7. doi: 10.1055/s-0032-1321506.


PMID- 24082810
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131001
LR  - 20211021
IS  - 1205-7088 (Print)
IS  - 1205-7088 (Linking)
VI  - 17
IP  - 8
DP  - 2012 Oct
TI  - Health care professionals' attitudes about pregnancy termination for different
      fetal anomalies.
PG  - e86-8
AB  - BACKGROUND: Health care professionals (HCPs) may be involved in counselling women
      after an antenatal diagnosis of various fetal anomalies. Many pregnant women
      consider termination of pregnancy (TOP) after antenatal diagnosis of various
      fetal anomalies. Little is known, however, about the attitudes of HCPs regarding 
      TOP for specific antenatal diagnoses. OBJECTIVE: To determine the attitudes and
      opinions of HCPs in maternal and child health regarding TOP for fetal anomalies
      of varying severity. METHODS: AN ANONYMOUS QUESTIONNAIRE WAS DISTRIBUTED TO FOUR 
      GROUPS OF HCPS: obstetric residents; paediatric residents; delivery room nurses; 
      and neonatal intensive care nurses. Respondents were asked about TOP if they or
      their spouse were to receive an antenatal diagnosis for five prenatally diagnosed
      conditions: trisomy 21; trisomy 18; cleft lip and palate; Turner syndrome; and
      hypoplastic left heart syndrome. RESULTS: Two hundred eighty HCPs answered the
      questionnaire (90% response rate). Ten per cent of respondents would not consider
      TOP under any of the circumstances described. Among those who would consider TOP,
      they were most likely to do so for trisomy 18 and least likely for cleft lip and 
      palate, and fairly evenly divided among the remaining three conditions
      (hypoplastic left heart syndrome [65%], trisomy 21 [56%] and Turner syndrome
      [37%]). Paediatric residents were less likely to choose TOP than other groups and
      obstetrics residents were most likely. CONCLUSIONS: Attitudes of HCPs toward TOP 
      vary according to prenatally identified condition and professional group. More
      rigorous analysis should be performed regarding the process of counselling and
      the impact of HCPs beliefs on parental decisions.
FAU - Janvier, Annie
AU  - Janvier A
AD  - University of Montreal, Sainte-Justine Hospital;
FAU - Couture, Elise
AU  - Couture E
FAU - Deschenes, Marianne
AU  - Deschenes M
FAU - Nadeau, Sophie
AU  - Nadeau S
FAU - Barrington, Keith
AU  - Barrington K
FAU - Lantos, John
AU  - Lantos J
LA  - eng
PT  - Journal Article
PL  - England
TA  - Paediatr Child Health
JT  - Paediatrics & child health
JID - 9815960
PMC - PMC3474393
OTO - NOTNLM
OT  - Ethics
OT  - Health care providers' opinions
OT  - Pregnancy termination
OT  - Prenatal counselling
OT  - Prenatal diagnosis
OT  - Trisomy 18
OT  - Trisomy 21
OT  - Turner syndrome
EDAT- 2013/10/02 06:00
MHDA- 2013/10/02 06:01
CRDT- 2013/10/02 06:00
PHST- 2012/06/27 00:00 [accepted]
PHST- 2013/10/02 06:00 [entrez]
PHST- 2013/10/02 06:00 [pubmed]
PHST- 2013/10/02 06:01 [medline]
AID - 10.1093/pch/17.8.e86 [doi]
PST - ppublish
SO  - Paediatr Child Health. 2012 Oct;17(8):e86-8. doi: 10.1093/pch/17.8.e86.


PMID- 24082807
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131001
LR  - 20211021
IS  - 1205-7088 (Print)
IS  - 1205-7088 (Linking)
VI  - 17
IP  - 8
DP  - 2012 Oct
TI  - Counselling and management for anticipated extremely preterm birth.
PG  - 443-6
AB  - Extremely preterm birth (birth between 22(0/7) and 25(6/7) weeks' gestational age
      [GA]) often requires parents to make complex choices about the care of their
      infant. Health professionals have a significant role in providing information,
      guidance and support. Parents facing the birth of an extremely preterm infant
      should have the chance to meet with both obstetrical and paediatric/neonatal care
      providers to receive accurate information about their infant's prognosis,
      provided with clarity and compassion. Decision making between parents and health 
      professionals should be an informed and shared process, with documentation of all
      management decisions. Consultation with and transfer to tertiary perinatal
      centres are important for the care of both mother and fetus. As the survival of
      infants born before or at 22 completed weeks' GA remains uncommon, a
      noninterventional approach is recommended, whereas at 23, 24 and 25 weeks' GA,
      counselling about outcomes and decision making should be individualized for each 
      infant and family, using factors which influence prognosis. All extremely preterm
      infants who are not resuscitated, or for whom resuscitation is not successful,
      must receive compassionate palliative care.
FAU - Jefferies, Ann L
AU  - Jefferies AL
FAU - Kirpalani, Haresh M
AU  - Kirpalani HM
CN  - Canadian Paediatric Society Fetus and Newborn Committee
LA  - eng
LA  - fre
PT  - Journal Article
PL  - England
TA  - Paediatr Child Health
JT  - Paediatrics & child health
JID - 9815960
PMC - PMC3474387
OTO - NOTNLM
OT  - Antenatal counselling
OT  - Ethics
OT  - Extreme prematurity
OT  - Resuscitation
EDAT- 2013/10/02 06:00
MHDA- 2013/10/02 06:01
CRDT- 2013/10/02 06:00
PHST- 2013/10/02 06:00 [entrez]
PHST- 2013/10/02 06:00 [pubmed]
PHST- 2013/10/02 06:01 [medline]
AID - 10.1093/pch/17.8.443 [doi]
PST - ppublish
SO  - Paediatr Child Health. 2012 Oct;17(8):443-6. doi: 10.1093/pch/17.8.443.


PMID- 24050474
OWN - NLM
STAT- MEDLINE
DCOM- 20140902
LR  - 20130920
IS  - 1536-7290 (Electronic)
IS  - 1536-7290 (Linking)
VI  - 13
IP  - 5
DP  - 2013
TI  - The effect of exercise intensity on coincidence anticipation performance at
      different stimulus speeds.
PG  - 559-66
LID - 10.1080/17461391.2012.752039 [doi]
AB  - The aim of this study was to examine the effect of exercise intensity on
      coincidence anticipation timing [CAT] performance at different stimulus speeds.
      Fourteen young adults (11 males and 3 females) volunteered to participate in the 
      study following ethical approval. After familiarisation, coincidence anticipation
      was measured using the Bassin Anticipation Timer under three conditions: rest,
      moderate-intensity and high-intensity exercise with stimulus speeds of 3, 5 and 8
      mph, set using an incremental running protocol until the participants reached a
      steady state of 70% and 90% of heart rate reserve (HRR), respectively. Results
      indicated a significant exercise intensity x stimulus speed interaction
      (p=0.0001) for absolute error (AE). There were no significant differences in AE
      across exercise intensities at a stimulus speed of 3 mph (p>0.05). AE was poorer 
      during high-intensity exercise (90% HRR) compared to rest (p=0.022), and
      moderate-intensity (70% HRR) exercise (all, p=0.004 or better) at 5 and 8 mph.
      Variable error (VE) was similar across exercise intensities at stimulus speeds of
      both 3 and 5 mph (p>0.05). At a stimulus speed of 8 mph, VE was significantly
      poorer during high-intensity exercise compared to rest (p=0.006) and
      moderate-intensity exercise (p=0.008). There were no significant differences for 
      constant error (p>0.05) across exercise intensities or stimulus speeds.
      High-intensity exercise is associated with poorer CAT performance. However,
      stimulus speed plays a key role within this association where faster stimulus
      speeds were associated with a more marked decrease in coincidence anticipation
      performance.
FAU - Duncan, Michael
AU  - Duncan M
AD  - a Department of Biomolecular and Sports Sciences , Coventry University , Coventry
      , UK.
FAU - Smith, Mike
AU  - Smith M
FAU - Lyons, Mark
AU  - Lyons M
LA  - eng
PT  - Journal Article
DEP - 20121220
PL  - England
TA  - Eur J Sport Sci
JT  - European journal of sport science
JID - 101146739
SB  - IM
MH  - Adult
MH  - *Anticipation, Psychological
MH  - Exercise Tolerance/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Motion Perception/*physiology
MH  - Physical Stimulation/methods
MH  - Psychomotor Performance/*physiology
MH  - Young Adult
EDAT- 2013/09/21 06:00
MHDA- 2014/09/03 06:00
CRDT- 2013/09/21 06:00
PHST- 2013/09/21 06:00 [entrez]
PHST- 2013/09/21 06:00 [pubmed]
PHST- 2014/09/03 06:00 [medline]
AID - 10.1080/17461391.2012.752039 [doi]
PST - ppublish
SO  - Eur J Sport Sci. 2013;13(5):559-66. doi: 10.1080/17461391.2012.752039. Epub 2012 
      Dec 20.


PMID- 24033235
OWN - NLM
STAT- MEDLINE
DCOM- 20140417
LR  - 20130916
IS  - 1545-5300 (Electronic)
IS  - 0014-7370 (Linking)
VI  - 52
IP  - 3
DP  - 2013 Sep
TI  - In the wake of violence: enacting and witnessing hope among people.
PG  - 355-67
LID - 10.1111/famp.12010 [doi]
AB  - In the territory of violence and despair, hope is rare. Recent work on hope has
      shifted attention from hope as a feeling to hope as a practice that people can do
      together. This case report of a family exposed to domestic violence highlights
      the role played by a South African police officer in the mother's actions to
      separate from the context of violence. As a witness to the violence, the police
      officer acted from an ethic of justice and an ethic of compassion. Outsider
      witnessing of a counseling session resulted in the recruiting of a community of
      acknowledgement for the mother, the police officer, and an Assistant Commissioner
      of Police. Listening carefully and doing hope together gave rise to alliances
      against practices of violence. As a step of accountability, the authors used
      reflexive practices to question their responses and to avoid colonizing
      practices.
CI  - (c) FPI, Inc.
FAU - Kotze, Elmarie
AU  - Kotze E
AD  - Department of Human Development and Counselling, University of Waikato, Hamilton,
      New Zealand.
FAU - Hulme, Therese
AU  - Hulme T
FAU - Geldenhuys, Tertius
AU  - Geldenhuys T
FAU - Weingarten, Kaethe
AU  - Weingarten K
LA  - eng
PT  - Journal Article
DEP - 20121129
PL  - United States
TA  - Fam Process
JT  - Family process
JID - 0400666
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anger
MH  - Child
MH  - Conduct Disorder/prevention & control/psychology/therapy
MH  - Cooperative Behavior
MH  - Counseling
MH  - Domestic Violence/*legislation & jurisprudence/prevention & control/*psychology
MH  - Empathy
MH  - Expert Testimony/*legislation & jurisprudence
MH  - Female
MH  - *Hope
MH  - Humans
MH  - Interdisciplinary Communication
MH  - Male
MH  - Narrative Therapy
MH  - Parenting/psychology
MH  - *Police/education
MH  - Psychosocial Deprivation
MH  - Residence Characteristics
MH  - Social Justice/legislation & jurisprudence
MH  - Social Responsibility
MH  - Social Support
MH  - South Africa
MH  - Volunteers
OTO - NOTNLM
OT  - Doing Hope Together
OT  - Domestic Violence
OT  - Ethic of Justice and Compassion
OT  - Witnessing Practices
EDAT- 2013/09/17 06:00
MHDA- 2014/04/18 06:00
CRDT- 2013/09/17 06:00
PHST- 2013/09/17 06:00 [entrez]
PHST- 2013/09/17 06:00 [pubmed]
PHST- 2014/04/18 06:00 [medline]
AID - 10.1111/famp.12010 [doi]
PST - ppublish
SO  - Fam Process. 2013 Sep;52(3):355-67. doi: 10.1111/famp.12010. Epub 2012 Nov 29.


PMID- 23997668
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130902
LR  - 20211021
IS  - 1531-0043 (Print)
IS  - 1530-9681 (Linking)
VI  - 25
IP  - 3
DP  - 2012 Sep
TI  - Colorectal surgeons teaching general surgery residents: current challenges and
      opportunities.
PG  - 134-42
LID - 10.1055/s-0032-1322526 [doi]
AB  - Effective teaching for general surgery residents requires that faculty members
      with colorectal expertise actively engage in the education process and fully
      understand the current context for residency training. In this article, we review
      important national developments with respect to graduate medical education that
      impact resident supervision, curriculum implementation, resident assessment, and 
      program evaluation. We argue that establishing a culture of respect and
      professionalism in today's teaching environment is one of the most important
      legacies that surgical educators can leave for the coming generation. Faculty
      role modeling and the process of socializing residents is highlighted. We review 
      the American College of Surgeons' Code of Professional Conduct, summarize some of
      the current strategies for teaching and assessing professionalism, and reflect on
      principles of motivation that apply to resident training both for the trainee and
      the trainer.
FAU - Schmitz, Connie C
AU  - Schmitz CC
AD  - Department of Surgery, University of Minnesota Medical School, Minneapolis,
      Minnesota.
FAU - Chow, Christopher J
AU  - Chow CJ
FAU - Rothenberger, David A
AU  - Rothenberger DA
LA  - eng
GR  - T32 CA132715/CA/NCI NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Clin Colon Rectal Surg
JT  - Clinics in colon and rectal surgery
JID - 101084157
PMC - PMC3577580
OTO - NOTNLM
OT  - graduate medical education
OT  - medical ethics
OT  - mentoring
OT  - professionalism
OT  - surgery residents
EDAT- 2013/09/03 06:00
MHDA- 2013/09/03 06:01
CRDT- 2013/09/03 06:00
PHST- 2013/09/03 06:00 [entrez]
PHST- 2013/09/03 06:00 [pubmed]
PHST- 2013/09/03 06:01 [medline]
AID - 10.1055/s-0032-1322526 [doi]
AID - 25134 [pii]
PST - ppublish
SO  - Clin Colon Rectal Surg. 2012 Sep;25(3):134-42. doi: 10.1055/s-0032-1322526.


PMID- 23990689
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 0092-8615 (Print)
IS  - 0092-8615 (Linking)
VI  - 46
IP  - 4
DP  - 2012 Jul
TI  - A Patient Focused Solution for Enrolling Clinical Trials in Rare and Selective
      Cancer Indications: A Landscape of Haystacks and Needles.
PG  - 472-478
AB  - Participation of adult cancer patients in US based clinical trials has remained
      near 3% for decades. Traditional research methodology reaches a small fraction of
      the target population with a fixed number of predetermined sites. Solutions are
      needed to ethically increase patient participation and accelerate cancer trial
      completion. We compared enrollment outcomes of traditional and patient focused
      research methodologies. A patient prioritized method (Just-In-Time, JIT) was
      implemented in parallel with traditionally managed sites in three cancer trials. 
      JIT research sites were initiated after candidate patients presented, while
      traditional sites were initiated in advance. JIT sites enrolled with mean rates
      no less than, and up to 2.75 fold greater than, traditional sites. Mean patients 
      enrolled per site was comparable (JIT-1.82, traditional-1.78). There were fewer
      non-enrolling JIT sites (2/28, 7%) compared to traditional sites 19/52, 37%).
      This retrospective analysis supports JIT as a prospective solution to increase
      cancer clinical trial enrollment and the efficiency of clinical trial
      administrative activities.
FAU - Lynam, Eric B
AU  - Lynam EB
AD  - Pharmatech Oncology, Inc., 789 Sherman Street, Suite 600, Denver, Colorado 80203.
FAU - Leaw, Jiin
AU  - Leaw J
FAU - Wiener, Matthew B
AU  - Wiener MB
LA  - eng
GR  - R43 CA144362/CA/NCI NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Drug Inf J
JT  - Drug information journal
JID - 0351461
PMC - PMC3754447
MID - NIHMS482638
EDAT- 2013/08/31 06:00
MHDA- 2013/08/31 06:01
CRDT- 2013/08/31 06:00
PHST- 2013/08/31 06:00 [entrez]
PHST- 2013/08/31 06:00 [pubmed]
PHST- 2013/08/31 06:01 [medline]
AID - 10.1177/0092861512443436 [doi]
PST - ppublish
SO  - Drug Inf J. 2012 Jul;46(4):472-478. doi: 10.1177/0092861512443436.


PMID- 23957105
OWN - NLM
STAT- MEDLINE
DCOM- 20130919
LR  - 20130820
IS  - 1029-4864 (Print)
IS  - 1029-4864 (Linking)
VI  - 67
IP  - 10
DP  - 2012 Nov
TI  - Dental ethics case 27. The orthodontic dilemma of non-compliance.
PG  - 596-7
FAU - Naidoo, S
AU  - Naidoo S
AD  - Faculty of Dentistry, University of the Western Cape. Department of Community
      Dentistry, Private Bag X1, Tygerberg. suenaidoo@uwc.ac.za
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - SADJ
JT  - SADJ : journal of the South African Dental Association = tydskrif van die
      Suid-Afrikaanse Tandheelkundige Vereniging
JID - 9812497
MH  - Adolescent
MH  - Adolescent Behavior/ethics
MH  - Attitude to Health
MH  - Dentist-Patient Relations/ethics
MH  - Dentists/*ethics
MH  - *Ethics, Dental
MH  - Humans
MH  - Male
MH  - Oral Hygiene/ethics
MH  - Orthodontics/*ethics
MH  - *Patient Compliance
MH  - Refusal to Treat/ethics
EDAT- 2013/08/21 06:00
MHDA- 2013/09/21 06:00
CRDT- 2013/08/21 06:00
PHST- 2013/08/21 06:00 [entrez]
PHST- 2013/08/21 06:00 [pubmed]
PHST- 2013/09/21 06:00 [medline]
PST - ppublish
SO  - SADJ. 2012 Nov;67(10):596-7.


PMID- 23951817
OWN - NLM
STAT- MEDLINE
DCOM- 20130919
LR  - 20131121
IS  - 1029-4864 (Print)
IS  - 1029-4864 (Linking)
VI  - 67
IP  - 8
DP  - 2012 Sep
TI  - Dental ethics case 25: the drug-abusing patient--what are my ethical obligations 
      to treat?
PG  - 474-5
FAU - Naidoo, S
AU  - Naidoo S
AD  - Faculty of Dentistry, University of the Western Cape, Department of Community
      Dentistry, Private Bag X1, Tygerberg 7505. suenaidoo@uwc.ac.za
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - SADJ
JT  - SADJ : journal of the South African Dental Association = tydskrif van die
      Suid-Afrikaanse Tandheelkundige Vereniging
JID - 9812497
RN  - 0 (Central Nervous System Stimulants)
RN  - 44RAL3456C (Methamphetamine)
MH  - *Amphetamine-Related Disorders/complications
MH  - Beneficence
MH  - *Central Nervous System Stimulants/adverse effects
MH  - Confidentiality
MH  - Dental Care/*ethics
MH  - Dentists/*ethics
MH  - *Ethics, Dental
MH  - Humans
MH  - *Methamphetamine/adverse effects
MH  - Personal Autonomy
MH  - Referral and Consultation
MH  - Social Justice
MH  - Tooth Diseases/etiology/therapy
EDAT- 2013/08/21 06:00
MHDA- 2013/09/21 06:00
CRDT- 2013/08/20 06:00
PHST- 2013/08/20 06:00 [entrez]
PHST- 2013/08/21 06:00 [pubmed]
PHST- 2013/09/21 06:00 [medline]
PST - ppublish
SO  - SADJ. 2012 Sep;67(8):474-5.


PMID- 23951806
OWN - NLM
STAT- MEDLINE
DCOM- 20130919
LR  - 20181202
IS  - 1029-4864 (Print)
IS  - 1029-4864 (Linking)
VI  - 67
IP  - 7
DP  - 2012 Aug
TI  - Dental ethics case 24. Non-therapeutic cosmetic treatments including botox.
PG  - 424-5
FAU - Naidoo, S
AU  - Naidoo S
AD  - Faculty of Dentistry, University of the Western Cape. Department of Community
      Dentistry, Tygerberg. suenaidoo@uwc.ac.za
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - SADJ
JT  - SADJ : journal of the South African Dental Association = tydskrif van die
      Suid-Afrikaanse Tandheelkundige Vereniging
JID - 9812497
RN  - 0 (Neuromuscular Agents)
RN  - EC 3.4.24.69 (Botulinum Toxins, Type A)
MH  - Beneficence
MH  - Botulinum Toxins, Type A/*therapeutic use
MH  - Cosmetic Techniques/*ethics
MH  - Dental Care/*ethics/legislation & jurisprudence
MH  - Dentists/*ethics/legislation & jurisprudence
MH  - *Ethics, Dental
MH  - Humans
MH  - Informed Consent/legislation & jurisprudence
MH  - Neuromuscular Agents/*therapeutic use
MH  - Personal Autonomy
MH  - South Africa
MH  - Truth Disclosure/ethics
EDAT- 2013/08/21 06:00
MHDA- 2013/09/21 06:00
CRDT- 2013/08/20 06:00
PHST- 2013/08/20 06:00 [entrez]
PHST- 2013/08/21 06:00 [pubmed]
PHST- 2013/09/21 06:00 [medline]
PST - ppublish
SO  - SADJ. 2012 Aug;67(7):424-5.


PMID- 23951753
OWN - NLM
STAT- MEDLINE
DCOM- 20130919
LR  - 20130819
IS  - 1029-4864 (Print)
IS  - 1029-4864 (Linking)
VI  - 67
IP  - 9
DP  - 2012 Oct
TI  - Dental ethics case 26. The incompetent geriatric patient.
PG  - 524-6
FAU - Naidoo, S
AU  - Naidoo S
AD  - Faculty of Dentistry, University of the Western Cape, Department of Community
      Dentistry, Private Bag X1, Tygerberg 7505. suenaidoo@uwc.ac.za
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - SADJ
JT  - SADJ : journal of the South African Dental Association = tydskrif van die
      Suid-Afrikaanse Tandheelkundige Vereniging
JID - 9812497
MH  - Aged
MH  - Alzheimer Disease/psychology
MH  - Decision Making
MH  - Dental Care for Aged/*ethics
MH  - Dentist-Patient Relations/ethics
MH  - Dentists/*ethics/legislation & jurisprudence
MH  - *Ethics, Dental
MH  - Humans
MH  - Informed Consent/ethics/legislation & jurisprudence
MH  - Legal Guardians/legislation & jurisprudence
MH  - *Mental Competency
MH  - Professional-Family Relations/ethics
MH  - South Africa
MH  - Third-Party Consent/legislation & jurisprudence
EDAT- 2013/08/21 06:00
MHDA- 2013/09/21 06:00
CRDT- 2013/08/20 06:00
PHST- 2013/08/20 06:00 [entrez]
PHST- 2013/08/21 06:00 [pubmed]
PHST- 2013/09/21 06:00 [medline]
PST - ppublish
SO  - SADJ. 2012 Oct;67(9):524-6.


PMID- 23923600
OWN - NLM
STAT- MEDLINE
DCOM- 20130827
LR  - 20151119
IS  - 0029-6503 (Print)
IS  - 0029-6503 (Linking)
VI  - 103
IP  - 6
DP  - 2012 Nov-Dec
TI  - Knowledge and attitude of nursing personnel regarding patient safety and rights
      in hospitals of Delhi.
PG  - 276-8
AB  - Nursing ethics apart, the increased awareness towards the treatment procedures
      being adopted and the standards of hygiene in the hospital setting necessitates
      proper knowledge and attitude of the personnel attending the patients. The
      present study, conducted in government and private hospitals of Delhi covered 200
      samples (100 each from government and private), using Structured Knowledge
      Questionnaire. It was revealed that majority of nursing staff working in private 
      hospitals had greater knowledge about patient safety and rights; they also had
      better patient-friendly attitude. It is suggested that nurses should practice
      with relevant guidelines in mind.
FAU - Geevarghese, Feba
AU  - Geevarghese F
AD  - College of Nursing, St Stephen's Hospital, Tis Hazari, Delhi.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Nurs J India
JT  - The Nursing journal of India
JID - 0376403
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Hospitals, Urban
MH  - Humans
MH  - India
MH  - Male
MH  - Nursing Staff, Hospital/*psychology
MH  - *Patient Rights
MH  - *Patient Safety
MH  - Surveys and Questionnaires
EDAT- 2013/08/09 06:00
MHDA- 2013/08/28 06:00
CRDT- 2013/08/09 06:00
PHST- 2013/08/09 06:00 [entrez]
PHST- 2013/08/09 06:00 [pubmed]
PHST- 2013/08/28 06:00 [medline]
PST - ppublish
SO  - Nurs J India. 2012 Nov-Dec;103(6):276-8.


PMID- 23922595
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130807
LR  - 20220408
IS  - 1735-9066 (Print)
IS  - 1735-9066 (Linking)
VI  - 17
IP  - 7
DP  - 2012 Nov
TI  - Iranian undergraduate nursing student perceptions of informal learning: A
      qualitative research.
PG  - 493-500
AB  - BACKGROUND: Nursing education is both formal and informal. Formal education
      represents only a small part of all the learning involved; and many students
      learn more effectively through informal processes. There is little information
      about nursing student informal education and how it affects their character and
      practice. MATERIALS AND METHODS: This qualitative study explores undergraduate
      nursing student perceptions of informal learning during nursing studies. Data
      were gathered through semi-structured interviews with a sample of undergraduate
      nursing students (n = 14). Strauss and Corbin's constant comparison analysis
      approach was used for data analysis. RESULTS: The categories that emerged
      included personal maturity and emotional development, social development,
      closeness to God, alterations in value systems, and ethical and professional
      commitment. CONCLUSION: Findings reveal that nursing education could take
      advantage of informal learning opportunities to develop students' nontechnical
      skills and produce more competent students. Implications for nursing education
      are discussed.
FAU - Seylani, Khatereh
AU  - Seylani K
AD  - Nursing and Midwifery Care Research Center, School of Nursing and Midwifery,
      Tehran University of Medical Sciences, Tehran, Iran.
FAU - Negarandeh, Reza
AU  - Negarandeh R
FAU - Mohammadi, Easa
AU  - Mohammadi E
LA  - eng
PT  - Journal Article
PL  - India
TA  - Iran J Nurs Midwifery Res
JT  - Iranian journal of nursing and midwifery research
JID - 101558775
EIN - Iran J Nurs Midwifery Res. 2014 Mar;19(2):216
EIN - Iran J Nurs Midwifery Res. 2014 Mar;19(2):216. PMID: 24834095
PMC - PMC3730452
OTO - NOTNLM
OT  - Informal learning
OT  - personal growth
OT  - qualitative study
OT  - undergraduate nursing education
EDAT- 2013/08/08 06:00
MHDA- 2013/08/08 06:01
CRDT- 2013/08/08 06:00
PHST- 2013/08/08 06:00 [entrez]
PHST- 2013/08/08 06:00 [pubmed]
PHST- 2013/08/08 06:01 [medline]
PST - ppublish
SO  - Iran J Nurs Midwifery Res. 2012 Nov;17(7):493-500.


PMID- 23922591
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130807
LR  - 20220330
IS  - 1735-9066 (Print)
IS  - 1735-9066 (Linking)
VI  - 17
IP  - 7
DP  - 2012 Nov
TI  - Perceptions and practices of fasting in Ramadan during pregnancy in Pakistan.
PG  - 467-71
AB  - BACKGROUND: Islam clearly exempts fasting in Ramadan during sickness, pregnancy, 
      and breastfeeding. Yet, some women prefer to fast despite realizing their
      increase in nutritional demand during pregnancy. Nurses and other healthcare
      providers face a difficult task of providing appropriate medical advice to Muslim
      women regarding the safety and impact of their fasting. The present study was
      conducted to examine the concepts and practices of maternal fasting during
      pregnancy in Pakistani Muslim women. MATERIALS AND METHODS: A cross-sectional
      study was done in 2008 on 353 females from gynecology departments of hospitals in
      major cities of two provinces of Pakistan. Non-probability convenient sampling
      technique was used and a questionnaire was used to collect data from females who 
      had experienced pregnancy during Ramadan at least once in life. Questions related
      to perceptions and practices of fasting in pregnancy along with demographic data 
      were asked. Analysis was done on SPSS version 16. Chi-square test was used to
      assess associations and P < 0.05 was considered statistically significant. All
      ethical considerations were taken into account for the respondents. RESULTS: Out 
      of the total, 309 (87.5%) fasted during their pregnancies while 43 (12.5%) did
      not fast at all. Among those who fasted, 42.5% (n = 150) fasted for the whole
      month, 23.8% (n = 84) fasted on alternate days, 10.5% (n = 37) fasted only on
      weekends/holidays, and 10.8% (n = 38) fasted on particular special days. The
      majority perceived no harm and risk caused by fasting to them or to fetus during 
      pregnancy. Although adverse effects during fasting were frequently reported, only
      24% break their fast. A significant association was found between gravida and
      education with fasting (P w< 0.05). A total of 88% of women believed that fasting
      during pregnancy (in good health) is "obligatory" while 12% thought otherwise.
      CONCLUSION: Pakistani Muslim women showed a strong compassion for fasting in
      pregnancy despite overall decrease in maternal health indicators. There is a need
      for nurses and other healthcare providers in all Muslim countries and especially 
      in non-Muslim countries with cultural diversity to be fully aware of the effects 
      of fasting in pregnancy so that they can act promptly ensuring safe and healthy
      delivery.
FAU - Mubeen, Syed M
AU  - Mubeen SM
AD  - Department of Community Health Sciences, Hamdard College of Medicine and
      Dentistry, Shahrah-e-Madinat al-Hikmah, Mohammed Bin Qasim Ave, Karachi,
      Pakistan.
FAU - Mansoor, Salman
AU  - Mansoor S
FAU - Hussain, Asad
AU  - Hussain A
FAU - Qadir, Shayan
AU  - Qadir S
LA  - eng
PT  - Journal Article
PL  - India
TA  - Iran J Nurs Midwifery Res
JT  - Iranian journal of nursing and midwifery research
JID - 101558775
PMC - PMC3730448
OTO - NOTNLM
OT  - Fasting
OT  - Islam
OT  - Pakistan
OT  - pregnancy
OT  - women
EDAT- 2013/08/08 06:00
MHDA- 2013/08/08 06:01
CRDT- 2013/08/08 06:00
PHST- 2013/08/08 06:00 [entrez]
PHST- 2013/08/08 06:00 [pubmed]
PHST- 2013/08/08 06:01 [medline]
PST - ppublish
SO  - Iran J Nurs Midwifery Res. 2012 Nov;17(7):467-71.


PMID- 23908842
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130805
LR  - 20211021
IS  - 2076-9172 (Print)
IS  - 2076-9172 (Linking)
VI  - 3
IP  - 3
DP  - 2012 Jul
TI  - Should we provide life-sustaining treatments to patients with permanent loss of
      cognitive capacities?
PG  - e0018
LID - 10.5041/RMMJ.10081 [doi]
AB  - A very troubling issue for health care systems today is that of life-sustaining
      treatment for patients who have permanently lost their cognitive capacities.
      These include patients in persistent vegetative state (PVS), or minimally
      conscious state (MCS), as well as a growing population of patients at the very
      end stage of dementia. These patients are totally dependent on life-sustaining
      treatments and are, actually, kept alive "artificially." This phenomenon raises
      doubts as to the ethics of sustaining the life of patients who have lost their
      consciousness and cognitive capacities, and whether there is a moral obligation
      to do so. The problem is that the main facts concerning the experiences and
      well-being of such patients and their wishes are unknown. Hence the framework of 
      the four principles-beneficence, non-maleficence, autonomy, and justice-is not
      applicable in these cases; therefore we examined solidarity as another moral
      value to which we may resort in dealing with this dilemma. This article shows
      that the source of the dilemma is the social attitudes towards loss of cognitive 
      capacities, and the perception of this state as loss of personhood. Consequently,
      it is suggested that the principle of solidarity-which both sets an obligation to
      care for the worst-off, and can be used to identify obligations that appeal to an
      ethos of behavior-can serve as a guiding principle for resolving the dilemma. The
      value of solidarity can lead society to care for these patients and not deny them
      basic care and life-sustaining treatment when appropriate.
FAU - Golan, Ofra G
AU  - Golan OG
AD  - The Gertner Institute for Epidemiology & Health Policy Research, Sheba Medical
      Center, Tel Hashomer, Israel; and.
FAU - Marcus, Esther-Lee
AU  - Marcus EL
LA  - eng
PT  - Journal Article
DEP - 20120731
PL  - Israel
TA  - Rambam Maimonides Med J
JT  - Rambam Maimonides medical journal
JID - 101538065
PMC - PMC3678818
OTO - NOTNLM
OT  - Dementia
OT  - ethics
OT  - life-sustaining treatment
OT  - minimally conscious state
OT  - persistent vegetative state
OT  - solidarity
EDAT- 2013/08/03 06:00
MHDA- 2013/08/03 06:01
CRDT- 2013/08/03 06:00
PHST- 2013/08/03 06:00 [entrez]
PHST- 2013/08/03 06:00 [pubmed]
PHST- 2013/08/03 06:01 [medline]
AID - 10.5041/RMMJ.10081 [doi]
AID - rmmj-3-3-e0018 [pii]
PST - epublish
SO  - Rambam Maimonides Med J. 2012 Jul 31;3(3):e0018. doi: 10.5041/RMMJ.10081. Print
      2012 Jul.


PMID- 23908565
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 0952-6951 (Print)
IS  - 0952-6951 (Linking)
VI  - 25
IP  - 5
DP  - 2012 Dec
TI  - The pursuit of happiness: The social and scientific origins of Hans Selye's
      natural philosophy of life.
PG  - 13-29
AB  - In 1956, Hans Selye tentatively suggested that the scientific study of stress
      could 'help us to formulate a precise program of conduct' and 'teach us the
      wisdom to live a rich and meaningful life'. Nearly two decades later, Selye
      expanded this limited vision of social order into a full-blown philosophy of
      life. In Stress without Distress, first published in 1974, he proposed an ethical
      code of conduct designed to mitigate personal and social problems. Basing his
      arguments on contemporary understandings of the biological processes involved in 
      stress reactions, Selye referred to this code as 'altruistic egotism'. This
      article explores the origins and evolution of Selye's 'natural philosophy of
      life', analysing the links between his theories and adjacent intellectual
      developments in biology, psychosomatic and psychosocial medicine, cybernetics and
      socio-biology, and situating his work in the broader cultural framework of modern
      western societies.
FAU - Jackson, Mark
AU  - Jackson M
AD  - University of Exeter, UK.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Hist Human Sci
JT  - History of the human sciences
JID - 100967737
PMC - PMC3724273
OTO - NOTNLM
OT  - Hans Selye
OT  - altruistic egotism
OT  - organic analogy
OT  - psychosomatic medicine
OT  - socio-biology
OT  - stress
EDAT- 2013/08/03 06:00
MHDA- 2013/08/03 06:01
CRDT- 2013/08/03 06:00
PHST- 2013/08/03 06:00 [entrez]
PHST- 2013/08/03 06:00 [pubmed]
PHST- 2013/08/03 06:01 [medline]
AID - 10.1177/0952695112468526 [doi]
AID - 10.1177_0952695112468526 [pii]
PST - ppublish
SO  - Hist Human Sci. 2012 Dec;25(5):13-29. doi: 10.1177/0952695112468526.


PMID- 23905061
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130801
LR  - 20211021
IS  - 2239-9747 (Print)
IS  - 2239-9747 (Linking)
VI  - 4
DP  - 2012 Sep
TI  - An engineering approach to biomedical sciences: advanced testing methods and
      pharmacokinetic modeling.
PG  - 34-8
AB  - In this paper, the philosophy of a research in pharmacology field, driven by an
      engineering approach, was described along with some case histories and examples. 
      The improvement in the testing methods for pharmaceutical systems (in-vitro
      techniques), as well as the proposal and the testing of mathematical models to
      describe the pharmacokinetics (in-silico techniques) are reported with the aim of
      pointing out methodologies and tools able to reduce the need of expensive and
      ethical problematic in-vivo measurements.
FAU - Lamberti, Gaetano
AU  - Lamberti G
AD  - Dipartimento di Ingegneria Industriale, Universita di Salerno, Salerno, Italy.
FAU - Cascone, Sara
AU  - Cascone S
FAU - Titomanlio, Giuseppe
AU  - Titomanlio G
LA  - eng
PT  - Journal Article
DEP - 20121011
PL  - Italy
TA  - Transl Med UniSa
JT  - Translational medicine @ UniSa
JID - 101588308
PMC - PMC3728799
OTO - NOTNLM
OT  - in-silico
OT  - in-vitro
OT  - in-vivo
OT  - pharmacokinetics
OT  - testing methods
EDAT- 2013/08/02 06:00
MHDA- 2013/08/02 06:01
CRDT- 2013/08/02 06:00
PHST- 2013/08/02 06:00 [entrez]
PHST- 2013/08/02 06:00 [pubmed]
PHST- 2013/08/02 06:01 [medline]
PST - epublish
SO  - Transl Med UniSa. 2012 Oct 11;4:34-8. Print 2012 Sep.


PMID- 23866517
OWN - NLM
STAT- MEDLINE
DCOM- 20130827
LR  - 20151119
IS  - 0030-9982 (Print)
IS  - 0030-9982 (Linking)
VI  - 62
IP  - 7
DP  - 2012 Jul
TI  - Awareness and ethical views regarding life support among doctors working in
      tertiary care facilities of Karachi, Pakistan.
PG  - 690-3
AB  - OBJECTIVE: To assess the knowledge of Life Support (LS) among doctors and to
      determine their ethical beliefs for the continuation or termination of Basic and 
      Advanced Life Support services. METHODS: This cross-sectional study was done from
      March to June 2009 that involved 110 doctors of three teaching Hospitals in
      Karachi (Jinnah Postgraduate Medical Centre, Aga Khan University and Ziauddin
      University hospitals). All the subjects were selected by random sampling and were
      then analysed on the basis of self-administered questionnaires. RESULTS: Out of
      the 110 doctors who took the survey, 109 (99%) had heard of Life Support. In the 
      breakdown of doctors, 1 out of the 18 consultants (5.6%), 5 of 45 PGs (11%) and 2
      out of 47 House Officers (4%) who took part in this study were unable to
      correctly identify the right definition of LS. Out of the total number (n = 110) 
      of doctors, 94 (85%) said they would use Life Support in their patients and 41
      (43%) of them thought life support was the only way the doctor can "do what he is
      supposed to do i.e. save a life", while the other reason for using LS was
      "Religiously, the right way". CONCLUSION: LS is still a highly sensitive subject 
      that needs still more awareness in Karachi, Pakistan. It was surprising to find
      out that the knowledge of LS by residents, postgraduates and even consultants was
      not as high as expected. Making Basic Life Support as a part of the undergraduate
      course might help in clarifying the discrepancies present in the knowledge of
      Life Support.
FAU - Rasheed, Shahida
AU  - Rasheed S
AD  - Department of Family Medicine, Ziauddin University, Karachi. sh-ra@hotmail.com
FAU - Saeed, Anum
AU  - Saeed A
FAU - Yazdanie, Noor
AU  - Yazdanie N
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - Pakistan
TA  - J Pak Med Assoc
JT  - JPMA. The Journal of the Pakistan Medical Association
JID - 7501162
SB  - IM
MH  - Cross-Sectional Studies
MH  - *Health Knowledge, Attitudes, Practice
MH  - Hospitals, Teaching
MH  - Hospitals, University
MH  - Humans
MH  - Life Support Care/*ethics
MH  - Pakistan
MH  - Physicians/*ethics/*psychology
MH  - Practice Patterns, Physicians'
MH  - Quality of Health Care
MH  - Surveys and Questionnaires
EDAT- 2013/07/23 06:00
MHDA- 2013/08/28 06:00
CRDT- 2013/07/23 06:00
PHST- 2013/07/23 06:00 [entrez]
PHST- 2013/07/23 06:00 [pubmed]
PHST- 2013/08/28 06:00 [medline]
AID - 3554 [pii]
PST - ppublish
SO  - J Pak Med Assoc. 2012 Jul;62(7):690-3.


PMID- 23866494
OWN - NLM
STAT- MEDLINE
DCOM- 20130827
LR  - 20130722
IS  - 0030-9982 (Print)
IS  - 0030-9982 (Linking)
VI  - 62
IP  - 12
DP  - 2012 Dec
TI  - Ethical review in Pakistan: the credibility gap.
PG  - 1354-7
AB  - The concept of mandatory ethical review of research involving human participants 
      is gradually taking root in Pakistani institutions. Based on the opinions of
      Institutional Review Board (IRB) members from institutions across the country,
      the process faces several challenges which threaten its integrity. The lack of
      registration or accreditation for IRBs has resulted in a wide variation in the
      calibre and working of such Boards. Despite the recent growth in numbers of
      people with formal bioethics degrees in the country, a majority of membership
      remains without any formal training for the work expected from them in ethical
      review. External pressures to influence deliberations, conflict of interest
      issues within board leadership and inconsistent application of review
      requirements all contribute in undermining the reliability of the process. Some
      of the most significant threats to independent and uninfluenced functioning of
      such boards arise from institutional leadership itself. In the opinions of IRB
      members, the review process has to be uniform, consistent and trustworthy if it
      is to gain the respect of researchers, and IRB need to be given the autonomous
      space to make independent decisions. Otherwise there is a real danger of IRBs
      being relegated to being no more than rubber stamping committees.
FAU - Jafarey, Aamir Mustafa
AU  - Jafarey AM
AD  - Centre of Biomedical Ethics and Culture, SIUT, Karachi. aamirjafarey@gmail.com
FAU - Iqbal, Saima Pervaiz
AU  - Iqbal SP
FAU - Hassan, Mariam
AU  - Hassan M
LA  - eng
PT  - Journal Article
PL  - Pakistan
TA  - J Pak Med Assoc
JT  - JPMA. The Journal of the Pakistan Medical Association
JID - 7501162
SB  - IM
MH  - Conflict of Interest
MH  - *Ethical Review
MH  - Ethics Committees, Research/*ethics/*standards
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Pakistan
EDAT- 2013/07/23 06:00
MHDA- 2013/08/28 06:00
CRDT- 2013/07/23 06:00
PHST- 2013/07/23 06:00 [entrez]
PHST- 2013/07/23 06:00 [pubmed]
PHST- 2013/08/28 06:00 [medline]
AID - 3877 [pii]
PST - ppublish
SO  - J Pak Med Assoc. 2012 Dec;62(12):1354-7.


PMID- 23857795
OWN - NLM
STAT- MEDLINE
DCOM- 20140630
LR  - 20151119
IS  - 1758-5872 (Electronic)
IS  - 1758-5864 (Linking)
VI  - 5
IP  - 1
DP  - 2013 Mar
TI  - Preliminary Turkish study of psychiatric in-patients' competence to make
      treatment decisions.
PG  - E9-E18
LID - 10.1111/appy.12000 [doi]
AB  - INTRODUCTION: Competence is a prerequisite for informed consent. Patients who are
      found to be competent are entitled to accept or refuse the proposed treatment. In
      recent years, there has been an increased interest in studies examining
      competence for treatment in psychiatric patients. In this study, we aimed to
      investigate the decision-making competencies of inpatients with a range of
      psychiatric diseases. METHODS: This study was carried out at the psychiatry
      clinic of Kocaeli University Hospital in Turkey from June 2007 to February 2008. 
      Decision-making competence was assessed in 83 patients using the MacArthur
      Competence Assessment Tool-Treatment (MacCAT-T). RESULTS: The study groups
      consisted of patients with mood (39.8%), psychotic (27.7%) and anxiety disorders 
      (18.1%), and alcohol/substance addiction (14.5%). There was a significant
      relation between decision-making competence and demographic and clinical
      characteristics. Appreciation of the given information was more impaired in
      psychotic disorder patients than in other patients, but understanding and
      reasoning of the given information was similar in all groups. DISCUSSION: These
      results reveal the importance of evaluating decision-making competencies of
      psychiatric patients before any treatment or intervention is carried out to
      ascertain their ability to give informed consent to treatment. Institutional and 
      national policies need to be determined and put into practice relating to the
      assessment and management of competence in patients with psychiatric disorders.
CI  - Copyright (c) 2012 Wiley Publishing Asia Pty Ltd.
FAU - Aydin Er, Rahime
AU  - Aydin Er R
AD  - Vocational School of Health, Kocaeli University, Kocaeli, Turkey.
      raay@kocaeli.edu.tr
FAU - Sehiralti, Mine
AU  - Sehiralti M
FAU - Aker, Ahmet Tamer
AU  - Aker AT
LA  - eng
PT  - Journal Article
DEP - 20121011
PL  - Australia
TA  - Asia Pac Psychiatry
JT  - Asia-Pacific psychiatry : official journal of the Pacific Rim College of
      Psychiatrists
JID - 101506757
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Decision Making/*ethics
MH  - Female
MH  - Hospitalization
MH  - Humans
MH  - Informed Consent/ethics/*psychology
MH  - Inpatients/psychology
MH  - Interview, Psychological/methods
MH  - Male
MH  - Mental Competency/*psychology
MH  - Mental Disorders/*psychology/therapy
MH  - Middle Aged
MH  - Patient Rights/ethics
MH  - Policy Making
MH  - Psychiatric Status Rating Scales
MH  - Psychiatry/*ethics/legislation & jurisprudence
MH  - Severity of Illness Index
MH  - Surveys and Questionnaires
MH  - Treatment Refusal/psychology
MH  - Turkey
MH  - Young Adult
OTO - NOTNLM
OT  - clinical ethics
OT  - informed consent
OT  - mental competence
OT  - patient
OT  - psychiatry
EDAT- 2013/07/17 06:00
MHDA- 2014/07/01 06:00
CRDT- 2013/07/17 06:00
PHST- 2012/01/10 00:00 [received]
PHST- 2012/08/15 00:00 [accepted]
PHST- 2013/07/17 06:00 [entrez]
PHST- 2013/07/17 06:00 [pubmed]
PHST- 2014/07/01 06:00 [medline]
AID - 10.1111/appy.12000 [doi]
PST - ppublish
SO  - Asia Pac Psychiatry. 2013 Mar;5(1):E9-E18. doi: 10.1111/appy.12000. Epub 2012 Oct
      11.


PMID- 23833585
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130708
LR  - 20211021
IS  - 1735-1995 (Print)
IS  - 1735-1995 (Linking)
VI  - 17
IP  - 11
DP  - 2012 Nov
TI  - Fraud and deceit in medical research.
PG  - 1077-81
AB  - Publication of medical research is the cornerstone for the propagation and
      dissemination of medical knowledge, culminating in significant effects on the
      health of the world's population. However, instances of individuals and
      institutions subverting the ethos of honesty and integrity on which medical
      research is built in order to advance personal ambitions have been well
      documented. Many definitions to describe this unethical behavior have been
      postulated, although the most descriptive is the "FFP" (fabrication,
      falsification, and plagiarism) model put forward by the United States' Office of 
      Research Integrity. Research misconduct has many ramifications of which the
      world's media are all too keen to demonstrate. Many high-profile cases the world 
      over have demonstrated this lack of ethics when performing medical research. Many
      esteemed professionals and highly regarded world institutions have succumbed to
      the ambitions of a few, who for personal gains, have behaved unethically in
      pursuit of their own ideals. Although institutions have been set up to directly
      confront these issues, it would appear that a lot more is still required on the
      part of journals and their editors to combat this behavioral pattern. Individuals
      starting out at very junior positions in medical research ought to be taught the 
      basics of medical research ethics so that populations are not failed by the very 
      people they are turning to for assistance at times of need. This article provides
      a review of many of the issues of research misconduct and allows the reader to
      reflect and think through their own experiences of research. This hopefully will 
      allow individuals to start asking questions on, what is an often, a poorly
      discussed topic in medical research.
FAU - Sarwar, Umran
AU  - Sarwar U
AD  - Division of Surgery, Department of Surgery and Cancer, Faculty of Medicine,
      Imperial College London, Hammersmith Hospital Campus, London W12 ONN, England.
FAU - Nicolaou, Marios
AU  - Nicolaou M
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Res Med Sci
JT  - Journal of research in medical sciences : the official journal of Isfahan
      University of Medical Sciences
JID - 101235599
PMC - PMC3702092
OTO - NOTNLM
OT  - Ethics
OT  - United States' office of Research Integrity
OT  - fraud
OT  - plagiarism
OT  - research
OT  - scientific misconduct
EDAT- 2013/07/09 06:00
MHDA- 2013/07/09 06:01
CRDT- 2013/07/09 06:00
PHST- 2012/05/08 00:00 [received]
PHST- 2012/06/18 00:00 [revised]
PHST- 2012/06/24 00:00 [accepted]
PHST- 2013/07/09 06:00 [entrez]
PHST- 2013/07/09 06:00 [pubmed]
PHST- 2013/07/09 06:01 [medline]
PST - ppublish
SO  - J Res Med Sci. 2012 Nov;17(11):1077-81.


PMID- 23823591
OWN - NLM
STAT- MEDLINE
DCOM- 20140303
LR  - 20161125
IS  - 1469-5804 (Electronic)
IS  - 1357-6283 (Linking)
VI  - 25
IP  - 2
DP  - 2012 Nov
TI  - Learning objects? Nurse educators' views on using patients for student learning :
      ethics and consent.
PG  - 92-7
LID - 10.4103/1357-6283.103455 [doi]
AB  - INTRODUCTION: This study explored the views of nursing lecturers concerning the
      use of patients in nursing education, particularly in light of the development of
      additional learning opportunities such as clinical simulation. METHODS: Focus
      group interviews involving 19 educators from one school of nursing in the United 
      Kingdom were held. An interview schedule was developed by the study team from the
      findings of a focused literature review of the area. The focus groups were
      audio-taped and transcribed into NVivo (version 8) for analysis and
      identification of emergent themes. RESULTS: Four major categories emerged from
      the data analysis: clinical placement; patient consent; educator conflict; and
      developing competency. The themes of clinical placement and patient consent are
      presented in this paper. Clinical placement revealed two sub-themes: historical
      custom and practice and safety. Four sub-themes emerged from the theme of patient
      consent: informed consent; implied consent; capacity to consent; and patients'
      value of student involvement in their care. DISCUSSION: Educators believed that
      patients benefit from being cared for by well-qualified nurses and to achieve
      this it is necessary for patients to participate in clinical training. The
      predominant view seemed to be one of historical necessity; essentially, it has
      always been done that way so it has to continue that way. There was an awareness 
      of the need for staff and students to consider the patient's rights and wishes,
      but the prevailing sentiment seemed to be that informed consent and choice were
      secondary to patient safety and the need to train student nurses. There is some
      conflict between the need for educating health professions and the Kantian view
      of never using the patients as a means to an end. Using patients for nursing
      education may be ethical as long as the patient is fully informed and involved in
      the decision-making process.
FAU - Torrance, C
AU  - Torrance C
AD  - HESAS, University of Glamorgan, United Kingdom. colintorrance@mac.com
FAU - Mansell, I
AU  - Mansell I
FAU - Wilson, C
AU  - Wilson C
LA  - eng
PT  - Journal Article
PL  - India
TA  - Educ Health (Abingdon)
JT  - Education for health (Abingdon, England)
JID - 9607101
SB  - IM
MH  - Attitude of Health Personnel
MH  - Education, Nursing/ethics/*methods
MH  - *Faculty, Nursing
MH  - Focus Groups
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Interviews as Topic
MH  - *Patients
MH  - United Kingdom
EDAT- 2013/07/05 06:00
MHDA- 2014/03/04 06:00
CRDT- 2013/07/05 06:00
PHST- 2013/07/05 06:00 [entrez]
PHST- 2013/07/05 06:00 [pubmed]
PHST- 2014/03/04 06:00 [medline]
AID - EducHealth_2012_25_2_92_103455 [pii]
AID - 10.4103/1357-6283.103455 [doi]
PST - ppublish
SO  - Educ Health (Abingdon). 2012 Nov;25(2):92-7. doi: 10.4103/1357-6283.103455.


PMID- 23823590
OWN - NLM
STAT- MEDLINE
DCOM- 20140303
LR  - 20130704
IS  - 1469-5804 (Electronic)
IS  - 1357-6283 (Linking)
VI  - 25
IP  - 2
DP  - 2012 Nov
TI  - Involving patients in medical education: ethical issues experienced by Syrian
      patients.
PG  - 87-91
LID - 10.4103/1357-6283.103453 [doi]
AB  - INTRODUCTION: Patients' involvement and their willingness to cooperate in
      clinical teaching is a vital element of medical education. Clinical teaching at
      the Faculty of Medicine of Damascus University relies heavily on inpatients at
      teaching hospitals but also on patients brought to teaching rooms. The purpose of
      this study was to identify patients' experiences and their attitudes toward the
      involvement of medical students in clinical consultations within teaching rooms
      conducted mainly for students' benefit. METHODS: In-depth interviews were carried
      out by a sociologist using an interview guide with 14 patients whose clinical
      cases were presented to a large group of students in the teaching room at
      Damascus University teaching hospitals. Data analysis involved content analysis. 
      FINDINGS: Main themes were identified with negative ethical aspects, such as the 
      lack of patient's involvement in decision making and approving to be part of
      clinical teaching. Risk and benefits were experienced by patients and identified 
      in their experiences. Some felt that they were treated inhumanely and with a lack
      of dignity. Patients nevertheless felt a responsibility to be part of the
      teaching process. They expressed their positive attitudes towards involvement in 
      the teaching process to serve medical students as well as the greater community. 
      DISCUSSION: Findings provide perspectives and insights into the current clinical 
      teaching at Damascus University Faculty of Medicine. The findings highlight the
      need in our institution to carry out medical education involving patients in a
      more ethical manner. Medical students and their teachers need more training in
      the ethical involvement of patients in students' learning process, as well as the
      need to better regulate patients' involvement in education.
FAU - Bashour, H
AU  - Bashour H
AD  - Department of Family and Community Medicine, Faculty of Medicine, and Centre for 
      Medical Education Development, Damascus University, Damascus, Syria.
      hbashour@scs-net.org
FAU - Sayed-Hassan, R
AU  - Sayed-Hassan R
FAU - Koudsi, A
AU  - Koudsi A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - India
TA  - Educ Health (Abingdon)
JT  - Education for health (Abingdon, England)
JID - 9607101
SB  - IM
MH  - Adult
MH  - Aged
MH  - Education, Medical/ethics/*methods
MH  - Ethics, Medical
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Middle Aged
MH  - Patient Participation/*methods
MH  - Patient Rights/ethics
MH  - Risk Assessment
MH  - Syria
MH  - Teaching
MH  - Young Adult
EDAT- 2013/07/05 06:00
MHDA- 2014/03/04 06:00
CRDT- 2013/07/05 06:00
PHST- 2013/07/05 06:00 [entrez]
PHST- 2013/07/05 06:00 [pubmed]
PHST- 2014/03/04 06:00 [medline]
AID - EducHealth_2012_25_2_87_103453 [pii]
AID - 10.4103/1357-6283.103453 [doi]
PST - ppublish
SO  - Educ Health (Abingdon). 2012 Nov;25(2):87-91. doi: 10.4103/1357-6283.103453.


PMID- 23807034
OWN - NLM
STAT- MEDLINE
DCOM- 20140102
LR  - 20220211
IS  - 1998-3654 (Electronic)
IS  - 0019-5359 (Linking)
VI  - 66
IP  - 7-8
DP  - 2012 Jul-Aug
TI  - Determination of insulin-like growth factor-I reference values using an
      immunoradiometric assay in a Brazilian adult population.
PG  - 155-63
AB  - BACKGROUND: Serum levels of total insulin-like growth factor I (IGF-I) reflect
      endogenous growth hormone (GH) secretion in healthy adults, which makes it a good
      diagnostic marker for screening of GH-related disorders. Studies also have
      supported a possible relation between IGF-I levels and the risk and prognostic
      for some malignancies, besides a relation between IGF-I levels and mortality.
      OBJECTIVE: As the determination of the IGF-I normal values for local populations 
      is strongly desired, the aim of this investigation was to determine reference
      values for IGF-I using an immunoradiometric assay (IRMA) in an adult Brazilian
      population of Rio de Janeiro city, since there is no other study using this
      methodology in Brazilian population, and that this method is widely used in
      Brazil and worldwide. MATERIALS AND METHODS: The study included samples of blood 
      taken from 484 healthy subjects (251 men and 233 women) aged 18-70. The subjects 
      agreed with this study, approved by the Ethical Committee of the Instituto
      Estadual de Hematologia Arthur de Siqueira Cavalcanti, Rio de Janeiro, Brazil.
      The samples were analyzed using a Diagnostic System Laboratories kit. For data
      analysis, age- and sex-specific figures were fitted after transformation of IGF-I
      values. RESULTS: In adulthood, a slow age-dependent decrease was found. There was
      no significant difference in IGF-I values between men and women. CONCLUSION: This
      study established age-specific IGF-I reference values, for a healthy Brazilian
      adult population, determined by a widely IGF-I, IRMA used currently in Brazil.
FAU - Leite, Denise B
AU  - Leite DB
AD  - Instituto de Estadual de Diabetes e Endocrinologia Luiz Capriglione, Universidade
      do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
FAU - Meirelles, Ricardo M R
AU  - Meirelles RM
FAU - Mandarim-De-Lacerda, Carlos A
AU  - Mandarim-De-Lacerda CA
FAU - Matos, Haroldo J
AU  - Matos HJ
FAU - Santos-Filho, Sebastiao D
AU  - Santos-Filho SD
FAU - Bernardo-Filho, Mario
AU  - Bernardo-Filho M
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Validation Study
PL  - India
TA  - Indian J Med Sci
JT  - Indian journal of medical sciences
JID - 0373023
RN  - 0 (Reagent Kits, Diagnostic)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Brazil
MH  - Chemistry, Clinical/*standards
MH  - Female
MH  - Humans
MH  - Immunoradiometric Assay/*standards
MH  - Insulin-Like Growth Factor I/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Reagent Kits, Diagnostic/*standards
MH  - Reference Values
MH  - Young Adult
EDAT- 2013/06/29 06:00
MHDA- 2014/01/03 06:00
CRDT- 2013/06/29 06:00
PHST- 2013/06/29 06:00 [entrez]
PHST- 2013/06/29 06:00 [pubmed]
PHST- 2014/01/03 06:00 [medline]
AID - IndianJMedSci_2012_66_7_155_114178 [pii]
PST - ppublish
SO  - Indian J Med Sci. 2012 Jul-Aug;66(7-8):155-63.


PMID- 23795344
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 2211-9124 (Print)
VI  - 1
IP  - 2
DP  - 2012 Dec 1
TI  - Can experience-based household food security scales help improve food security
      governance?
PG  - 120-125
AB  - Experience-based food security scales (EBFSSs) have been shown to be valid across
      world regions. EBFSSs are increasingly been included in national food and
      nutrition assessments and food hardship items have been added to regional and
      global public opinion polls. EBFSSs meet the SMART criteria for identifying
      useful indicators. And have the potential to help improve accountability,
      transparency, intersectoral coordination and a more effective and equitable
      distribution of resources. EBFSSs have increased awareness about food and
      nutrition insecurity in the court of public opinion. Thus, it's important to
      understand the potential that EBFSSs have for improving food and nutrition
      security governance within and across countries. The case of Brazil illustrates
      the strong likelihood that EBFSSs do have a strong potential to influence food
      and governance from the national to the municipal level. A recent Gallup World
      Poll data analysis on the influence of the '2008 food crisis' on food hardship
      illustrates how even a single item from EBFSSs can help examine if food security 
      governance in different world regions modifies the impact of crises on household 
      food insecurity. Systematic research that bridges across economics, political
      science, ethics, public health and program evaluation is needed to better
      understand if and how measurement in general and EBFSSs in particular affect food
      security governance.
FAU - Perez-Escamilla, Rafael
AU  - Perez-Escamilla R
AD  - Yale School of Public Health.
LA  - eng
GR  - P20 MD001765/MD/NIMHD NIH HHS/United States
PT  - Journal Article
PL  - Netherlands
TA  - Glob Food Sec
JT  - Global food security
JID - 101596689
PMC - PMC3685197
MID - NIHMS422810
OTO - NOTNLM
OT  - experience-based food security scales
OT  - food security
OT  - governance
OT  - nutrition security
EDAT- 2013/06/25 06:00
MHDA- 2013/06/25 06:01
CRDT- 2013/06/25 06:00
PHST- 2013/06/25 06:00 [entrez]
PHST- 2013/06/25 06:00 [pubmed]
PHST- 2013/06/25 06:01 [medline]
AID - 10.1016/j.gfs.2012.10.006 [doi]
PST - ppublish
SO  - Glob Food Sec. 2012 Dec 1;1(2):120-125. doi: 10.1016/j.gfs.2012.10.006.


PMID- 23767014
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130617
LR  - 20211021
IS  - 2229-5070 (Print)
IS  - 2229-5070 (Linking)
VI  - 2
IP  - 2
DP  - 2012 Jul
TI  - Ethics of funding of research.
PG  - 89-90
LID - 10.4103/2229-5070.105172 [doi]
FAU - Mandal, Jharna
AU  - Mandal J
AD  - Department of Microbiology, JIPMER, Puducherry, India. E-mail:
      subhashparija@yahoo.co.in.
FAU - Parija, Madhuri
AU  - Parija M
FAU - Parija, Subhash Chandra
AU  - Parija SC
LA  - eng
PT  - Journal Article
PL  - India
TA  - Trop Parasitol
JT  - Tropical parasitology
JID - 101580198
PMC - PMC3680878
EDAT- 2013/06/15 06:00
MHDA- 2013/06/15 06:01
CRDT- 2013/06/15 06:00
PHST- 2012/12/02 00:00 [received]
PHST- 2012/12/28 00:00 [accepted]
PHST- 2013/06/15 06:00 [entrez]
PHST- 2013/06/15 06:00 [pubmed]
PHST- 2013/06/15 06:01 [medline]
AID - 10.4103/2229-5070.105172 [doi]
AID - TP-2-89 [pii]
PST - ppublish
SO  - Trop Parasitol. 2012 Jul;2(2):89-90. doi: 10.4103/2229-5070.105172.


PMID- 23741583
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130607
LR  - 20211021
IS  - 2006-8808 (Print)
IS  - 2006-8808 (Linking)
VI  - 4
IP  - 2
DP  - 2012 Jul
TI  - "The Dendritic Bonding Technique": A Newly-devised Technique for the Fixation of 
      Mesh Skin Graft.
PG  - 92-3
LID - 10.4103/2006-8808.110258 [doi]
AB  - We describe a newly designed technique for the quick, easy, and cost-effective
      fixation of mesh skin grafts in a range of skin conditions and patients. We fixed
      the skin graft using octyl-2-cyanoacrylate (Dermabond; Ethicon), which was termed
      "Dendritic bonding." This technique exhibits several advantages over surgical
      stapling and suturing with absorbable sutures.
FAU - Sakamoto, Yoshiaki
AU  - Sakamoto Y
AD  - Department of Plastic and Reconstructive Surgery, Keio University School of
      Medicine, 35 Shinanomachi, Shinjuku-ward, Tokyo, Japan.
FAU - Kishi, Kazuo
AU  - Kishi K
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Surg Tech Case Rep
JT  - Journal of surgical technique and case report
JID - 101540507
PMC - PMC3673368
OTO - NOTNLM
OT  - Dermabond
OT  - mesh
OT  - octyl-2-cyanoacrylate
OT  - skin graft
EDAT- 2013/06/07 06:00
MHDA- 2013/06/07 06:01
CRDT- 2013/06/07 06:00
PHST- 2013/06/07 06:00 [entrez]
PHST- 2013/06/07 06:00 [pubmed]
PHST- 2013/06/07 06:01 [medline]
AID - 10.4103/2006-8808.110258 [doi]
AID - JSTCR-4-92 [pii]
PST - ppublish
SO  - J Surg Tech Case Rep. 2012 Jul;4(2):92-3. doi: 10.4103/2006-8808.110258.


PMID- 23741242
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1792-1074 (Print)
IS  - 1792-1074 (Linking)
VI  - 4
IP  - 3
DP  - 2012 Sep
TI  - Antitumor activity of placenta-derived mesenchymal stem cells producing pigment
      epithelium-derived factor in a mouse melanoma model.
PG  - 413-418
AB  - Mesenchymal stem cells (MSCs) are a new tool that can be used for the delivery of
      therapeutic agents to tumor cells. Among the various types of MSCs,
      placenta-derived MSCs (PDMSCs) have emerged as one of the most attractive
      vehicles for gene therapy due to their high throughput, lack of ethical concerns,
      non-invasive procedure for their harvesting and ease of isolation. In this study,
      we evaluated the antitumor activity of human PDMSCs loaded with recombinant
      adenoviruses expressing pigment epithelium-derived factor (PEDF). PDMSCs were
      transduced with adenovirus PEDF and the expression of PEDF was confirmed by
      western blotting and ELISA. The inhibition of angiogenesis mediated by
      PEDF-expressing PDMSCs (PDMSC-PEDF) was determined using human umbilical vein
      endothelial cell (HUVEC) proliferation inhibition assay and migration inhibition 
      assay in vitro. In in vivo experiments, C57BL/6 mice bearing B16-F10 melanoma
      were treated with intratumoral injection of PDMSC-PEDF twice at a 4-day interval.
      The tumor volume and weight were recorded. The results demonstrated that the
      administration of PDMSC-PEDF resulted in marked suppression of tumor growth in an
      established melanoma model, which was associated with a decreased number of
      microvessels and increased apoptosis of tumor cells compared with the controls.
      The results suggest that human PDMSCs have potential use as effective delivery
      vehicles for cancer gene therapy.
FAU - Chen, Qiaoling
AU  - Chen Q
AD  - State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West
      China Medical School, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
FAU - Cheng, Ping
AU  - Cheng P
FAU - Song, Na
AU  - Song N
FAU - Yin, Tao
AU  - Yin T
FAU - He, Hong
AU  - He H
FAU - Yang, Li
AU  - Yang L
FAU - Chen, Xiancheng
AU  - Chen X
FAU - Wei, Yuquan
AU  - Wei Y
LA  - eng
PT  - Journal Article
DEP - 20120622
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC3673651
OTO - NOTNLM
OT  - anti-angiogenesis
OT  - gene therapy
OT  - melanoma
OT  - mesenchymal stem cells
OT  - pigment epithelium-derived factor
EDAT- 2013/06/07 06:00
MHDA- 2013/06/07 06:01
CRDT- 2013/06/07 06:00
PHST- 2012/02/22 00:00 [received]
PHST- 2012/05/24 00:00 [accepted]
PHST- 2013/06/07 06:00 [entrez]
PHST- 2013/06/07 06:00 [pubmed]
PHST- 2013/06/07 06:01 [medline]
AID - 10.3892/ol.2012.772 [doi]
AID - ol-04-03-0413 [pii]
PST - ppublish
SO  - Oncol Lett. 2012 Sep;4(3):413-418. doi: 10.3892/ol.2012.772. Epub 2012 Jun 22.


PMID- 23738304
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130606
LR  - 20211021
IS  - 2240-4554 (Print)
IS  - 2240-4554 (Linking)
VI  - 2
IP  - 3
DP  - 2012 Jul
TI  - Cell therapy: cGMP facilities and manufacturing.
PG  - 243-7
AB  - Advanced therapies constitute one of the most complex, organizational, and
      regulatory areas currently approached by clinical researchers in order to explore
      new therapeutic applications. Basic scientists and clinicians trying to implement
      cell therapies into clinical practice, may feel overwhelmed by the apparently
      endless regulatory requirements that apply. However, regulatory agencies have
      primary responsibility on patient safety and law enforcement are, and should be, 
      their main considerations. Cell- and tissue-based therapies have the potential to
      treat many conditions, where present conventional treatments are inadequate. The 
      current approach to cell- and tissue-based therapy development requires using
      good manufacturing production facilities through master and working cell banks.
      Facilities need to be purpose-designed and accredited by their national medicinal
      regulatory body and production scientists need to work in close tandem with
      quality assurances and ethics committees to absolutely ensure the safety of this 
      cellular products.
FAU - Giancola, Raffaella
AU  - Giancola R
AD  - Department of Transfusion Medicine, Pescara Civil Hospital, Italy.
FAU - Bonfini, Tiziana
AU  - Bonfini T
FAU - Iacone, Antonio
AU  - Iacone A
LA  - eng
PT  - Journal Article
DEP - 20121016
PL  - Italy
TA  - Muscles Ligaments Tendons J
JT  - Muscles, ligaments and tendons journal
JID - 101600853
PMC - PMC3666518
OTO - NOTNLM
OT  - MSC
OT  - manufacturing
OT  - tissue engineering
EDAT- 2013/06/06 06:00
MHDA- 2013/06/06 06:01
CRDT- 2013/06/06 06:00
PHST- 2013/06/06 06:00 [entrez]
PHST- 2013/06/06 06:00 [pubmed]
PHST- 2013/06/06 06:01 [medline]
PST - epublish
SO  - Muscles Ligaments Tendons J. 2012 Oct 16;2(3):243-7. Print 2012 Jul.


PMID- 23738298
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130606
LR  - 20211021
IS  - 2240-4554 (Print)
IS  - 2240-4554 (Linking)
VI  - 2
IP  - 3
DP  - 2012 Jul
TI  - Stem cell research and clinical development in tendon repair.
PG  - 204-11
AB  - Stem cells are one of the most fascinating areas in regenerative medicine today. 
      They play a crucial role in development and regeneration and are defined as cells
      that continuously reproduce themselves while maintaining the ability to
      differentiate into various cell types. Stem cells are found at all developmental 
      stages, from embryonic stem cells (ESCs) which differentiate into all cell types,
      to adult stem cells (ASCs) which are responsible for tissue regeneration. Studies
      using animal models have shown promising results following cell therapy for
      induced injury in musculoskeletal system, including tendon healing, but the
      results can be variable. Alternative sources for cell therapy in tendon pathology
      may include ESCs, ASCs (bone marrow, adipose tissue or tendon derived stem cells)
      or induced pluripotent stem cells (iPSCs). While ethical and safety concerns
      currently forbid clinical application of ESCs and iPSCs, initial clinical trials 
      with ASCs are promising.
FAU - Filomeno, Paola
AU  - Filomeno P
AD  - Hospital de Clinicas. Facultad de Medicina. Universidad de la Republica &
      Instituto de Traumatologia y Ortopedia de Adultos. Ministerio de Salud Publica.
FAU - Dayan, Victor
AU  - Dayan V
FAU - Tourino, Cristina
AU  - Tourino C
LA  - eng
PT  - Journal Article
DEP - 20121016
PL  - Italy
TA  - Muscles Ligaments Tendons J
JT  - Muscles, ligaments and tendons journal
JID - 101600853
PMC - PMC3666527
OTO - NOTNLM
OT  - adult stem cells
OT  - cell therapy
OT  - embryonic stem cell
OT  - induced pluripotent stem cells
OT  - mesenchimal stromal cells
OT  - tendon repair
EDAT- 2013/06/06 06:00
MHDA- 2013/06/06 06:01
CRDT- 2013/06/06 06:00
PHST- 2013/06/06 06:00 [entrez]
PHST- 2013/06/06 06:00 [pubmed]
PHST- 2013/06/06 06:01 [medline]
PST - epublish
SO  - Muscles Ligaments Tendons J. 2012 Oct 16;2(3):204-11. Print 2012 Jul.


PMID- 23738296
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130606
LR  - 20211021
IS  - 2240-4554 (Print)
IS  - 2240-4554 (Linking)
VI  - 2
IP  - 3
DP  - 2012 Jul
TI  - Stem cell therapy of tendinopathies: suggestions from veterinary medicine.
PG  - 187-92
AB  - The ideal strategy for tendon healing has not been identified to date. Recently, 
      the use of stem cells based therapy has been proposed, due to their ability to
      proliferate and to differentiate towards specific connective tissues lineages.
      Embryonic stem cells should be considered the ideal cell source for regenerative 
      therapies, but ethical factors limit their use in humans. Mesenchymal stem cells 
      are more easily available and can be obtained by different sources. Amnion
      derived stem cells can differentiate towards all three germ layers, and can be
      used for allogeneic transplantation and stored thanks to cryopreservation. In
      veterinary medicine, stem cells have been used with encouraging results for the
      treatment of the Superficial Digital Flexor tendinopathy in the horses.
      Considering that Superficial Digital Flexor tendinopathy is similar for
      pathogenesis and histopathology to Achilles tendinopathy in man, this experience 
      can provide supportive data to encourage the use of regenerative therapy in
      humans.
FAU - Muttini, Aurelio
AU  - Muttini A
AD  - Department of Comparative Biomedical Sciences, University of Teramo, Italy ; Stem
      TeCh group, Chieti Scalo, Italy.
FAU - Salini, Vincenzo
AU  - Salini V
FAU - Valbonetti, Luca
AU  - Valbonetti L
FAU - Abate, Michele
AU  - Abate M
LA  - eng
PT  - Journal Article
DEP - 20121016
PL  - Italy
TA  - Muscles Ligaments Tendons J
JT  - Muscles, ligaments and tendons journal
JID - 101600853
PMC - PMC3666520
OTO - NOTNLM
OT  - Achilles tendon
OT  - stem cells
OT  - tendinopathy
EDAT- 2013/06/06 06:00
MHDA- 2013/06/06 06:01
CRDT- 2013/06/06 06:00
PHST- 2013/06/06 06:00 [entrez]
PHST- 2013/06/06 06:00 [pubmed]
PHST- 2013/06/06 06:01 [medline]
PST - epublish
SO  - Muscles Ligaments Tendons J. 2012 Oct 16;2(3):187-92. Print 2012 Jul.


PMID- 23735094
OWN - NLM
STAT- MEDLINE
DCOM- 20131226
LR  - 20130605
IS  - 1742-7924 (Electronic)
IS  - 1742-7924 (Linking)
VI  - 10
IP  - 1
DP  - 2013 Jun
TI  - Ethical issues in practice: a survey of home-visiting nurses in Japan.
PG  - 98-108
LID - 10.1111/j.1742-7924.2012.00216.x [doi]
AB  - AIM: The purposes of this study were to identify specific components and
      frequencies of ethical issues that home-visiting nurses encountered in their
      practice, relationships between ethical issues and demographic data, and
      experience of ethics education and workplace environment. METHODS: A
      self-administered questionnaire was distributed to home-visiting nurses in Japan.
      Usable data (1961) were analyzed. RESULTS: Item and exploratory factor analysis
      for the frequency of encountering ethical issues revealed: (i) concern about
      respecting client or relationships with relevant professionals; (ii) differences 
      in treatment or care-taking views among home-visiting nurse and client and
      family, or relevant professionals; and (iii) discrepancy of intention between
      family and client or home-visiting nurse. All factors were significantly
      positively related to the current position, duration of working experience as a
      home-visiting nurse, and type of nursing education; age was significantly
      negatively related. Home-visiting nurses noted that programmed continuing
      education systems and staff-training programs were not sufficiently available.
      CONCLUSION: The findings of this study indicated the characteristics of ethical
      issues that home-visiting nurses encountered in their practice and insufficient
      continuing education system including ethics education. Ethics education programs
      tailored to home-visiting nurses ethical concerns and traits and continuing
      education systems are needed.
CI  - (c) 2012 The Authors. Japan Journal of Nursing Science (c) 2012 Japan Academy of 
      Nursing Science.
FAU - Asahara, Kiyomi
AU  - Asahara K
AD  - Department of Nursing Science, St Luke's College of Nursing, Tokyo, Japan.
      asahara@slcn.ac.jp
FAU - Ono, Wakanako
AU  - Ono W
FAU - Kobayashi, Maasa
AU  - Kobayashi M
FAU - Omori, Junko
AU  - Omori J
FAU - Momose, Yumiko
AU  - Momose Y
FAU - Todome, Hiromi
AU  - Todome H
FAU - Konishi, Emiko
AU  - Konishi E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120603
PL  - Japan
TA  - Jpn J Nurs Sci
JT  - Japan journal of nursing science : JJNS
JID - 101227890
SB  - IM
MH  - Community Health Nursing
MH  - *Ethics
MH  - Female
MH  - *House Calls
MH  - Humans
MH  - Japan
MH  - Male
MH  - *Nurses
EDAT- 2013/06/06 06:00
MHDA- 2013/12/27 06:00
CRDT- 2013/06/06 06:00
PHST- 2013/06/06 06:00 [entrez]
PHST- 2013/06/06 06:00 [pubmed]
PHST- 2013/12/27 06:00 [medline]
AID - 10.1111/j.1742-7924.2012.00216.x [doi]
PST - ppublish
SO  - Jpn J Nurs Sci. 2013 Jun;10(1):98-108. doi: 10.1111/j.1742-7924.2012.00216.x.
      Epub 2012 Jun 3.


PMID- 23730786
OWN - NLM
STAT- MEDLINE
DCOM- 20140109
LR  - 20151119
IS  - 1440-1630 (Electronic)
IS  - 0045-0766 (Linking)
VI  - 60
IP  - 3
DP  - 2013 Jun
TI  - Towards a definition of professionalism in Australian occupational therapy: using
      the Delphi technique to obtain consensus on essential values and behaviours.
PG  - 206-16
LID - 10.1111/1440-1630.12017 [doi]
AB  - BACKGROUND/AIM: Professionalism involves practitioners applying the values of
      their profession and demonstrating essential professional behaviours and
      attitudes. Within the Australian occupational therapy profession, there is little
      research on the values, behaviours and attitudes that constitute professionalism.
      As a result, there is limited understanding of professionalism, and the
      approaches used to enhance the professionalism of future practitioners are not
      evidence based. This study aimed to contribute to the understanding of
      professionalism within the Australian occupational therapy profession, by
      obtaining consensus among Australian occupational therapists on the professional 
      values and behaviours essential for practice. METHOD: A constructivist paradigm
      guided this study. The Delphi technique was used to obtain consensus on essential
      professional values and behaviours among 68 occupational therapists. Consensus
      was identified by numerical and content analysis. RESULTS: After two Delphi
      rounds, 61 professional values were identified as essential for practice. These
      values related to ethical practice, client-centred practice, contemporary
      practice and to the foundational beliefs of the profession. Seven professional
      behaviours also achieved consensus, but there was clear disparity in
      participants' opinions. CONCLUSION: The results provide insight into several
      professional values and behaviours perceived as essential for practice.
      Consequently, these professional values need to be taken into consideration when 
      defining the values of the profession. The professional behaviours need to be
      taken into account when finalising the essential behaviours that constitute
      professionalism in the profession. This study takes an initial but fundamental
      step towards defining professionalism within the Australian occupational therapy 
      profession.
CI  - (c) 2012 The Authors Australian Occupational Therapy Journal (c) 2012
      Occupational Therapy Australia.
FAU - Aguilar, Alejandra
AU  - Aguilar A
AD  - School of Pharmacy and Medical Sciences, Division of Health Sciences, University 
      of South Australia, Adelaide, South Australia, Australia.
      aguae001@mymail.unisa.edu.au
FAU - Stupans, Ieva
AU  - Stupans I
FAU - Scutter, Sheila
AU  - Scutter S
FAU - King, Sharron
AU  - King S
LA  - eng
PT  - Journal Article
DEP - 20121219
PL  - Australia
TA  - Aust Occup Ther J
JT  - Australian occupational therapy journal
JID - 15420200R
SB  - IM
MH  - Australia
MH  - *Delphi Technique
MH  - Female
MH  - Humans
MH  - Male
MH  - Occupational Therapy/*standards
MH  - Professional Competence/*standards
MH  - Professional Practice/*standards
MH  - Surveys and Questionnaires
EDAT- 2013/06/05 06:00
MHDA- 2014/01/10 06:00
CRDT- 2013/06/05 06:00
PHST- 2012/10/14 00:00 [accepted]
PHST- 2013/06/05 06:00 [entrez]
PHST- 2013/06/05 06:00 [pubmed]
PHST- 2014/01/10 06:00 [medline]
AID - 10.1111/1440-1630.12017 [doi]
PST - ppublish
SO  - Aust Occup Ther J. 2013 Jun;60(3):206-16. doi: 10.1111/1440-1630.12017. Epub 2012
      Dec 19.


PMID- 23730567
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130605
LR  - 20211021
IS  - 2231-3796 (Print)
IS  - 2231-3796 (Linking)
VI  - 64
IP  - 2
DP  - 2012 Jun
TI  - Preimplantation genetic diagnosis and deafness.
PG  - 103-5
LID - 10.1007/s12070-012-0569-7 [doi]
AB  - Deafness in India ranges from 4.0 % in urban and 4.0-11 % in rural and slum
      areas, out of which 50 % are of conductive hearing loss hence curable. In the
      congenital hearing loss the incidence of syndromic hearing loss is only 30 %,
      rest 70 % are non syndromic. Genetic counseling is going to make aware the
      parents. Preimplantation genetic diagnosis can help to have a baby free from
      genetic deafness. Procedure is almost safe, harmless, non-invasive and ethically 
      acceptable. While by genetic testing through prenatal genetic testing,
      amniocentesis and chorionic villous sampling is invasive and termination of
      pregnancy is difficult, social and ethical issue. The connexin 26 (CX26W 24X) has
      been observed as most common and easy to identify by polymerase chain reaction.
      There is always co morbidity after cochlear implantation and the person remains
      handicapped while baby after PGD shall be having healthy normal life and person
      prone to environmental factors may be counseled and guided to prevent deafness in
      next generation. Public must be made aware of noise pollution, tobacco toxicity
      and consanguinity. The obstetrician and pediatrician apart from ENT surgeon
      should be involved to prevent antenatal or neonatal deafness.
FAU - Taneja, M K
AU  - Taneja MK
AD  - E-982, Chitranjan Park, New Delhi, 110019 India.
LA  - eng
PT  - Journal Article
DEP - 20120630
PL  - India
TA  - Indian J Otolaryngol Head Neck Surg
JT  - Indian journal of otolaryngology and head and neck surgery : official publication
      of the Association of Otolaryngologists of India
JID - 9422551
PMC - PMC3392352
OTO - NOTNLM
OT  - Genetic diagnosis
OT  - National deafness programme
OT  - Preimplantation
OT  - Sensoneural deafness
EDAT- 2013/06/05 06:00
MHDA- 2013/06/05 06:01
CRDT- 2013/06/05 06:00
PHST- 2012/05/12 00:00 [received]
PHST- 2012/06/12 00:00 [accepted]
PHST- 2013/06/05 06:00 [entrez]
PHST- 2013/06/05 06:00 [pubmed]
PHST- 2013/06/05 06:01 [medline]
AID - 10.1007/s12070-012-0569-7 [doi]
AID - 569 [pii]
PST - ppublish
SO  - Indian J Otolaryngol Head Neck Surg. 2012 Jun;64(2):103-5. doi:
      10.1007/s12070-012-0569-7. Epub 2012 Jun 30.


PMID- 23730449
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130605
LR  - 20211021
IS  - 1949-8349 (Print)
IS  - 1949-8357 (Linking)
VI  - 4
IP  - 2
DP  - 2012 Jun
TI  - Development of a Test of Residents' Ethics Knowledge for Pediatrics (TREK-P).
PG  - 242-5
LID - 10.4300/JGME-D-11-00280.1 [doi]
AB  - BACKGROUND: Professionalism is one of the Accreditation Council for Graduate
      Medical Education's core competencies. Residency programs must teach residents
      about ethical principles, which is an essential component of professionalism.
      OBJECTIVES: We aimed to formally develop a valid and reliable test of ethics
      knowledge that effectively discriminated among learners in pediatric residency
      training and to improve methods for measuring outcomes of resident education in
      medical ethics. METHODS: We created an instrument with 36 true/false questions
      that tested knowledge in several domains of pediatric ethics: professionalism,
      adolescent medicine, genetic testing and diagnosis, neonatology, end-of-life
      decisions, and decision making for minors. All questions and their correct
      answers were derived from published statements from the American Academy of
      Pediatrics Committee on Bioethics. We invited a range of participants from
      novices to experts to complete the test. We evaluated the instrument's
      reliability and explored item discrimination, omitting 13 items with the least
      discriminatory power. Score differences between the 3 categories of examinees
      were evaluated. RESULTS: The 23-item test, completed by 54 participants,
      demonstrated good internal reliability (Kuder-Richardson 20 statistic = 0.73).
      The test was moderately difficult and had a mean overall score of 17.3 (+/-3.3
      standard deviation). Performance appropriately improved with degree of expertise:
      median scores for medical students, postgraduate year-3 residents, and ethicists 
      were 15 (65%, range, 11-19), 19 (83%, range, 14-23), and 22 (96%, range, 20-23), 
      respectively. Ethicists' scores were significantly higher than those of medical
      students (P < .001) and residents (P = .007). Moreover, residents performed
      significantly better than medical students (P = .001). CONCLUSIONS: We developed 
      a standardized instrument, entitled Test of Residents' Ethics Knowledge for
      Pediatrics (TREK-P), to evaluate residents' knowledge of pediatric ethics. The
      TREK-P is easy to administer, reliably discriminates among learners, and
      highlights content areas in which knowledge may be deficient.
FAU - Kesselheim, Jennifer C
AU  - Kesselheim JC
FAU - McMahon, Graham T
AU  - McMahon GT
FAU - Joffe, Steven
AU  - Joffe S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Grad Med Educ
JT  - Journal of graduate medical education
JID - 101521733
PMC - PMC3399620
EDAT- 2013/06/05 06:00
MHDA- 2013/06/05 06:01
CRDT- 2013/06/05 06:00
PHST- 2011/11/15 00:00 [received]
PHST- 2011/01/12 00:00 [revised]
PHST- 2011/01/16 00:00 [accepted]
PHST- 2013/06/05 06:00 [entrez]
PHST- 2013/06/05 06:00 [pubmed]
PHST- 2013/06/05 06:01 [medline]
AID - 10.4300/JGME-D-11-00280.1 [doi]
AID - JGME-D-11-00280.1 [pii]
PST - ppublish
SO  - J Grad Med Educ. 2012 Jun;4(2):242-5. doi: 10.4300/JGME-D-11-00280.1.


PMID- 23730436
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130605
LR  - 20211021
IS  - 1949-8349 (Print)
IS  - 1949-8357 (Linking)
VI  - 4
IP  - 2
DP  - 2012 Jun
TI  - Postinterview Communication between Obstetrics and Gynecology Residency Programs 
      and Candidates.
PG  - 165-9
LID - 10.4300/JGME-D-11-00114.1 [doi]
AB  - INTRODUCTION: Residency programs seek to match the best candidates with their
      positions. To avoid ethical conflicts in this process, the National Residency
      Matching Program (NRMP or Match) has rules regarding appropriate conduct,
      including guidelines on contact between candidates and programs. Our study
      examined communication between obstetrics and gynecology (Ob-Gyn) programs and
      residency candidates after interviewing and prior to ranking. METHODS: Ob-Gyn
      program directors in the United States were sent a self-administered survey via
      e-mail. Data were collected and analyzed using descriptive methods to examine
      communication practices of these programs. RESULTS: The response rate was 40%.
      The findings showed that respondents had variable interpretations of the NRMP
      rules and suggest that programs may be communicating their match intentions
      especially to favored candidates. Respondents' open text comments highlighted
      program directors' frustrations with current NRMP rules. DISCUSSION: NRMP
      communication rules are intended to minimize pressure on residency candidates.
      Our findings suggest they may be leading to unforeseen stresses on program
      directors and candidates. CONCLUSIONS: As educational leaders in medicine, we
      must consider what professional communications are acceptable without increasing 
      the pressure on candidates during the ranking and match process.
FAU - Curran, Diana S
AU  - Curran DS
FAU - Andreatta, Pamela B
AU  - Andreatta PB
FAU - Xu, Xiao
AU  - Xu X
FAU - Nugent, Clark E
AU  - Nugent CE
FAU - Dewald, Samantha R
AU  - Dewald SR
FAU - Johnson, Timothy R B
AU  - Johnson TR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Grad Med Educ
JT  - Journal of graduate medical education
JID - 101521733
PMC - PMC3399607
EDAT- 2013/06/05 06:00
MHDA- 2013/06/05 06:01
CRDT- 2013/06/05 06:00
PHST- 2011/05/18 00:00 [received]
PHST- 2011/11/02 00:00 [revised]
PHST- 2011/11/02 00:00 [revised]
PHST- 2011/12/06 00:00 [accepted]
PHST- 2013/06/05 06:00 [entrez]
PHST- 2013/06/05 06:00 [pubmed]
PHST- 2013/06/05 06:01 [medline]
AID - 10.4300/JGME-D-11-00114.1 [doi]
AID - JGME-D-11-00114.1 [pii]
PST - ppublish
SO  - J Grad Med Educ. 2012 Jun;4(2):165-9. doi: 10.4300/JGME-D-11-00114.1.


PMID- 23730360
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130605
LR  - 20211021
IS  - 1872-5325 (Print)
IS  - 1872-5325 (Linking)
VI  - 6
IP  - 1-2
DP  - 2012 Jun
TI  - Microbial synthetic biology for human therapeutics.
PG  - 9-22
LID - 10.1007/s11693-012-9092-0 [doi]
AB  - The emerging field of synthetic biology holds tremendous potential for developing
      novel drugs to treat various human conditions. The current study discusses the
      scope of synthetic biology for human therapeutics via microbial approach. In this
      context, synthetic biology aims at designing, engineering and building new
      microbial synthetic cells that do not pre-exist in nature as well as re-engineer 
      existing microbes for synthesis of therapeutic products. It is expected that the 
      construction of novel microbial genetic circuitry for human therapeutics will
      greatly benefit from the data generated by 'omics' approaches and
      multidisciplinary nature of synthetic biology. Development of novel antimicrobial
      drugs and vaccines by engineering microbial systems are a promising area of
      research in the field of synthetic biology for human theragnostics. Expression of
      plant based medicinal compounds in the microbial system using synthetic biology
      tools is another avenue dealt in the present study. Additionally, the study
      suggest that the traditional medicinal knowledge can do value addition for
      developing novel drugs in the microbial systems using synthetic biology tools.
      The presented work envisions the success of synthetic biology for human
      therapeutics via microbial approach in a holistic manner. Keeping this in view,
      various legal and socio-ethical concerns emerging from the use of synthetic
      biology via microbial approach such as patenting, biosafety and biosecurity
      issues have been touched upon in the later sections.
FAU - Jain, Aastha
AU  - Jain A
AD  - Kusuma School of Biological Sciences, Indian Institute of Technology Delhi, Hauz 
      Khas, New Delhi, 110 016 India.
FAU - Bhatia, Pooja
AU  - Bhatia P
FAU - Chugh, Archana
AU  - Chugh A
LA  - eng
PT  - Journal Article
DEP - 20120602
PL  - Germany
TA  - Syst Synth Biol
JT  - Systems and synthetic biology
JID - 101300404
PMC - PMC3424199
OTO - NOTNLM
OT  - Antibiotics
OT  - Biosafety
OT  - Diseases
OT  - Intellectual property
OT  - Metabolic engineering
OT  - Secondary metabolites
OT  - Traditional knowledge
EDAT- 2013/06/05 06:00
MHDA- 2013/06/05 06:01
CRDT- 2013/06/05 06:00
PHST- 2012/03/07 00:00 [received]
PHST- 2012/05/07 00:00 [revised]
PHST- 2012/05/08 00:00 [accepted]
PHST- 2013/06/05 06:00 [entrez]
PHST- 2013/06/05 06:00 [pubmed]
PHST- 2013/06/05 06:01 [medline]
AID - 10.1007/s11693-012-9092-0 [doi]
AID - 9092 [pii]
PST - ppublish
SO  - Syst Synth Biol. 2012 Jun;6(1-2):9-22. doi: 10.1007/s11693-012-9092-0. Epub 2012 
      Jun 2.


PMID- 23730169
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130605
LR  - 20211021
IS  - 1205-7088 (Print)
IS  - 1205-7088 (Linking)
VI  - 17
IP  - 6
DP  - 2012 Jun
TI  - Ethics application protocols for multicentre clinical studies in Canada: A
      paediatric rheumatology experience.
PG  - 313-6
AB  - INTRODUCTION: Individual institutions govern research ethics applications and
      each must administer and regulate their own protocols. Variations in ethics
      review procedures and expectations among centres impose impediments to
      efficiently conducting multicentre studies. METHODS: Observations relating to
      preparing multisite ethics documents for a study conducted by Canadian paediatric
      rheumatology investigators are described. Research ethics applications from the
      12 participating centres were compared. RESULTS: Although the applications were
      similar in their content, they differed in their formatting. All applications
      shared a commitment to ensuring that the study conformed to exemplary ethical
      standards. CONCLUSIONS: There is wide variation in the multicentre clinical study
      ethics application process at the institutional level. Considering the common
      fundamental elements required by all ethics review boards, the present study
      conceptualized introducing a discipline-specific uniform ethics application
      process acceptable to all Canadian research ethics boards. This may be a more
      efficient strategy that could help lessen the burden of collaborative research.
FAU - Matheson, Loren A
AU  - Matheson LA
AD  - Department of Pediatrics, University of Saskatchewan; Saskatoon, Saskatchewan;
FAU - Huber, Adam M
AU  - Huber AM
FAU - Warner, Aleasha
AU  - Warner A
FAU - Rosenberg, Alan M
AU  - Rosenberg AM
LA  - eng
PT  - Journal Article
PL  - England
TA  - Paediatr Child Health
JT  - Paediatrics & child health
JID - 9815960
PMC - PMC3380748
OTO - NOTNLM
OT  - Ethics
OT  - Multicentre studies
OT  - Paediatrics
OT  - Rheumatology
EDAT- 2013/06/05 06:00
MHDA- 2013/06/05 06:01
CRDT- 2013/06/05 06:00
PHST- 2012/02/02 00:00 [accepted]
PHST- 2013/06/05 06:00 [entrez]
PHST- 2013/06/05 06:00 [pubmed]
PHST- 2013/06/05 06:01 [medline]
PST - ppublish
SO  - Paediatr Child Health. 2012 Jun;17(6):313-6.


PMID- 23729915
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 0144-686X (Print)
IS  - 0144-686X (Linking)
VI  - 33
IP  - 5
DP  - 2013 Jul
TI  - Care robots for the supermarket shelf: a product gap in assistive technologies.
PG  - 763-781
AB  - The literature on the development of assistive robots is dominated by
      technological papers with little consideration of how such devices might be
      commercialised for a mass market at a price that is affordable for older people
      and their families as well as public services and care insurers. This article
      argues that the focus of technical development in this field is too ambitious,
      neglecting the potential market for an affordable device that is aleady in the
      realm of the 'adjacent possible' given current technology capabilities. It also
      questions on both ethical and marketing grounds the current effort to develop
      assistive robots with pet-like or human-like features. The marketing literature
      on 'really new products' has so far not appeared to inform the development of
      assistive robots but has some important lessons. These include using analogies
      with existing products and giving particular attention to the role of early
      adopters. Relevant analogies for care robots are not animals or humans but useful
      domestic appliances and personal technologies with attractive designs, engaging
      functionality and intuitive usability. This points to a strategy for enabling
      mass adoption - which has so far eluded even conventional telecare - of
      emphasising how such an appliance is part of older people's contemporary
      lifestyles rather than a sign of age-related decline and loss of independence.
FAU - Blackman, Tim
AU  - Blackman T
AD  - School of Social Sciences , The Open University , UK .
LA  - eng
PT  - Journal Article
DEP - 20120423
PL  - England
TA  - Ageing Soc
JT  - Ageing and society
JID - 8109358
PMC - PMC3665953
OTO - NOTNLM
OT  - assistive technology
OT  - older consumers
OT  - really new products
OT  - robots
OT  - telecare
EDAT- 2013/06/05 06:00
MHDA- 2013/06/05 06:01
CRDT- 2013/06/05 06:00
PHST- 2012/02/20 00:00 [accepted]
PHST- 2013/06/05 06:00 [entrez]
PHST- 2013/06/05 06:00 [pubmed]
PHST- 2013/06/05 06:01 [medline]
AID - 10.1017/S0144686X1200027X [doi]
AID - 00027 [pii]
PST - ppublish
SO  - Ageing Soc. 2013 Jul;33(5):763-781. doi: 10.1017/S0144686X1200027X. Epub 2012 Apr
      23.


PMID- 23729821
OWN - NLM
STAT- MEDLINE
DCOM- 20130920
LR  - 20211021
IS  - 0008-5286 (Print)
IS  - 0008-5286 (Linking)
VI  - 53
IP  - 12
DP  - 2012 Dec
TI  - An ethicist's commentary on the dog with Cushing's syndrome.
PG  - 1246
FAU - Rollin, Bernard E
AU  - Rollin BE
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Canada
TA  - Can Vet J
JT  - The Canadian veterinary journal = La revue veterinaire canadienne
JID - 0004653
SB  - IM
CIN - Can Vet J. 2013 Mar;54(3):202-4. PMID: 23997255
CIN - Can Vet J. 2013 Mar;54(3):204. PMID: 23997256
MH  - Animals
MH  - Costs and Cost Analysis
MH  - Cushing Syndrome/diagnosis/therapy/*veterinary
MH  - Dog Diseases/diagnosis/*therapy
MH  - Dogs
MH  - *Ethics, Professional
MH  - Euthanasia, Animal
MH  - Human-Animal Bond
MH  - Male
MH  - Socioeconomic Factors
MH  - Veterinary Medicine/*economics/*ethics
PMC - PMC3500113
EDAT- 2013/06/05 06:00
MHDA- 2013/09/21 06:00
CRDT- 2013/06/05 06:00
PHST- 2013/06/05 06:00 [entrez]
PHST- 2013/06/05 06:00 [pubmed]
PHST- 2013/09/21 06:00 [medline]
PST - ppublish
SO  - Can Vet J. 2012 Dec;53(12):1246.


PMID- 26201807
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150728
LR  - 20181113
IS  - 1936-0533 (Print)
IS  - 1936-0533 (Linking)
VI  - 7
IP  - 2
DP  - 2013 Jun
TI  - Short- and long-term outcomes of third liver transplantation at single centre.
PG  - 728-33
LID - 10.1007/s12072-012-9364-5 [doi]
AB  - PURPOSE: Although three or more liver transplantation (LT)s in the same patient
      arouse not only medical but also ethical issues in the context of organ shortage,
      it is a fact that additional liver retransplantation (reLT) is the only
      lifesaving treatment option for those with graft failure after a second LT.
      However, little is known regarding the risks and benefits associated with a third
      LT. METHODS: We analyzed fifteen cases of third LT and 48 of second LT performed 
      between January 2000 and December 2010. Clinical outcomes were compared with
      those of second LT cases performed during the same period. RESULTS: Model for
      end-stage liver disease (MELD) scores at transplant was similar between the two
      groups. As for surgical aspects, there was no significant difference in operative
      time or number of units of red blood cells transfused during the transplant
      procedures between the groups. Patient and graft survival after the third LT at
      1, 3, and 10 years were 66.7, 51.9, and 44.4 %, and 66.7, 51.9, and 29.6 %,
      respectively. There was no significant difference in patient or graft survival
      between the groups. However, graft loss within 3 months after the third LT was
      significantly higher than that of second LT patients. CONCLUSION: Third LT cases 
      showed acceptable short- and long-term outcomes that were not significantly
      inferior to those of a second LT. Careful patient care especially in the early
      phase after a third LT may be essential to improve the outcome.
FAU - Kamei, Hideya
AU  - Kamei H
AD  - Multi-Organ Transplant Program, University Hospital of Ontario, London Health
      Science Centre, 339 Windermere Road, London, ON, N6A 5A5, Canada.
      kamei@med.nagoya-u.ac.jp.
FAU - Al-Basheer, Mamoun
AU  - Al-Basheer M
AD  - Multi-Organ Transplant Program, University Hospital of Ontario, London Health
      Science Centre, 339 Windermere Road, London, ON, N6A 5A5, Canada.
FAU - Shum, Jeffrey
AU  - Shum J
AD  - Multi-Organ Transplant Program, University Hospital of Ontario, London Health
      Science Centre, 339 Windermere Road, London, ON, N6A 5A5, Canada.
FAU - Bloch, Michael
AU  - Bloch M
AD  - Multi-Organ Transplant Program, University Hospital of Ontario, London Health
      Science Centre, 339 Windermere Road, London, ON, N6A 5A5, Canada.
FAU - Alejandro, Roberto Hernandez
AU  - Alejandro RH
AD  - Multi-Organ Transplant Program, University Hospital of Ontario, London Health
      Science Centre, 339 Windermere Road, London, ON, N6A 5A5, Canada.
FAU - McAlister, Vivian
AU  - McAlister V
AD  - Multi-Organ Transplant Program, University Hospital of Ontario, London Health
      Science Centre, 339 Windermere Road, London, ON, N6A 5A5, Canada.
FAU - Wall, William
AU  - Wall W
AD  - Multi-Organ Transplant Program, University Hospital of Ontario, London Health
      Science Centre, 339 Windermere Road, London, ON, N6A 5A5, Canada.
FAU - Quan, Douglas
AU  - Quan D
AD  - Multi-Organ Transplant Program, University Hospital of Ontario, London Health
      Science Centre, 339 Windermere Road, London, ON, N6A 5A5, Canada.
LA  - eng
PT  - Journal Article
DEP - 20120314
PL  - United States
TA  - Hepatol Int
JT  - Hepatology international
JID - 101304009
OTO - NOTNLM
OT  - Donor shortage
OT  - Liver retransplantation
OT  - Patient survival
OT  - Single centre analysis
OT  - Third liver transplantation
EDAT- 2013/06/01 00:00
MHDA- 2013/06/01 00:01
CRDT- 2015/07/24 06:00
PHST- 2011/11/03 00:00 [received]
PHST- 2012/02/29 00:00 [accepted]
PHST- 2015/07/24 06:00 [entrez]
PHST- 2013/06/01 00:00 [pubmed]
PHST- 2013/06/01 00:01 [medline]
AID - 10.1007/s12072-012-9364-5 [doi]
AID - 10.1007/s12072-012-9364-5 [pii]
PST - ppublish
SO  - Hepatol Int. 2013 Jun;7(2):728-33. doi: 10.1007/s12072-012-9364-5. Epub 2012 Mar 
      14.


PMID- 23716942
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130530
LR  - 20211021
IS  - 0971-6866 (Print)
IS  - 1998-362X (Linking)
VI  - 18
IP  - 3
DP  - 2012 Sep
TI  - Genetic significance of muscle segment homeo box1 gene in South Indian population
      for cleft lip and palate.
PG  - 332-9
LID - 10.4103/0971-6866.107988 [doi]
AB  - BACKGROUND: Oral clefts having a prehistoric existence and the latest scientific 
      technologies have shown new insights in identifying the cause and management. So 
      this is a DNA/gene based study has been presented in this article which comprises
      the significance of MSX1 gene in cleft samples of major states of South India.
      AIMS: To evaluate the significance of MSX1 gene in South Indian population having
      cleft lip and palate. SETTINGS AND DESIGN: Four states of native population were 
      set for the study. From each state renowned cleft operating center was selected
      with the prior ethical and suitable permission and patient consent was taken.
      Blood samples were collected from each effected sibling were studied and their
      details were coded. The collected blood samples were used for DNA isolation, PCR 
      amplification and sequencing. MATERIALS AND METHODS: Eighty patients with
      non-syndromic CL/CLP/CP from various cleft operating centers in southern states
      (Karnataka, Tamilnadu, Kerala and Andhra Pradesh) with different ethnic/cultural 
      background were taken. Twenty samples (families) were collected from each state
      and sequenced and compared with earlier data. RESULTS: Analysis of this study
      indicates that mutation of either G273A/C or C102G seems to cause cleft
      formation. In this analysis, we found a novel mutation (414G to T) which is
      submitted to NCBI Gene data bank (EF065625). CONCLUSION: This study supports MSX1
      gene leading to cleft lip and palate in the samples studied.
FAU - Prasad, Venkanna S
AU  - Prasad VS
AD  - Department of Oral and Maxillofacial Surgery, Government Dental College,
      Bangalore, Karnataka, India.
FAU - Shivani, Venkatesh
AU  - Shivani V
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Hum Genet
JT  - Indian journal of human genetics
JID - 101223637
PMC - PMC3656523
OTO - NOTNLM
OT  - Cleft lip and palate
OT  - muscle segment homeo box1
OT  - polymerase chain reaction
OT  - sequencing
EDAT- 2013/05/30 06:00
MHDA- 2013/05/30 06:01
CRDT- 2013/05/30 06:00
PHST- 2013/05/30 06:00 [entrez]
PHST- 2013/05/30 06:00 [pubmed]
PHST- 2013/05/30 06:01 [medline]
AID - 10.4103/0971-6866.107988 [doi]
AID - IJHG-18-332 [pii]
PST - ppublish
SO  - Indian J Hum Genet. 2012 Sep;18(3):332-9. doi: 10.4103/0971-6866.107988.


PMID- 23678631
OWN - NLM
STAT- MEDLINE
DCOM- 20130701
LR  - 20130516
IS  - 0309-3913 (Print)
IS  - 0309-3913 (Linking)
VI  - 41 Suppl
DP  - 2012 Dec
TI  - Researching the vulnerables: issues of consent and ethical approval.
PG  - 7-11
AB  - Imagine you are a biomedical scientist attempting to cross a busy, beggar-crowded
      road in Lagos. You suddenly notice that the loud horns of the speeding cars,
      trucks and trailers draw no visible physiologic response from any of the beggars 
      including their children and babies, unlike the rest of the crowd. Consequently, 
      certain questions such as the following begin to engage your mind: Is this
      phenomenon a kind of habituation? If so, is its onset the same for the blind ones
      amongst them? Have these beggars acquired a neural system absent from "normal"
      people? If so, just how long does it take for such a system to be established? At
      the very height of this creative outburst, you however realize that the informed 
      consent and ethical approval you would need for this particular research differs 
      from the type you have previously encountered in your career.... Although the
      above scenario suggests that new and difficult ethical questions may confront
      scientists while pursuing their curiosity, our research ethics guidelines do not 
      currently address this issue. This paper explores some of the ethical challenges 
      involved in carrying out basic research on vulnerable subjects such as beggars.
      It highlights how the notions of autonomy and informed consent in this context
      become vague, thus, liable to exploitation. Ultimately, the paper offers a useful
      framework in relation to developing a research ethics committee charged with the 
      moral mandate of overseeing the integrity of research involving this vulnerable
      population in particular and basic biomedical research in general.
FAU - Afolabi, M O S
AU  - Afolabi MO
AD  - Chemical Pathology Unit, Department of Biomedical Sciences, Ladoke Akintola
      University of Technology, Ogbomosho, Oyo State, Nigeria. curiousmaikl@yahoo.com
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Nigeria
TA  - Afr J Med Med Sci
JT  - African journal of medicine and medical sciences
JID - 7801013
SB  - IM
MH  - Biomedical Research
MH  - Ethics Committees, Research/*organization & administration
MH  - Ethics, Research
MH  - *Human Experimentation/ethics/standards
MH  - Humans
MH  - Informed Consent/ethics
MH  - Nigeria
MH  - Poverty
MH  - *Vulnerable Populations
EDAT- 2013/05/18 06:00
MHDA- 2013/07/03 06:00
CRDT- 2013/05/18 06:00
PHST- 2013/05/18 06:00 [entrez]
PHST- 2013/05/18 06:00 [pubmed]
PHST- 2013/07/03 06:00 [medline]
PST - ppublish
SO  - Afr J Med Med Sci. 2012 Dec;41 Suppl:7-11.


PMID- 23677198
OWN - NLM
STAT- MEDLINE
DCOM- 20131115
LR  - 20130516
IS  - 0717-6163 (Electronic)
IS  - 0034-9887 (Linking)
VI  - 140
IP  - 11
DP  - 2012 Nov
TI  - [The law of rights and duties of persons in health care from the viewpoint of
      bioethics].
PG  - 1490-4
LID - 10.4067/S0034-98872012001100017 [doi]
LID - S0034-98872012001100017 [pii]
AB  - The enactment of Law 20.584 in April of 2012 promotes a change in the
      physician-patient relationship, with recognition of people's rights and duties in
      healthcare by all the health professional and entities. The legal obligation, and
      not only the ethical one, as it currently happens, for humane treatment and
      regard for the dignity of the sick, informed consent, medical data
      confidentiality, the possibility to reject treatments, etc., is established. This
      review analyzes the contents of this law, especially those parts affecting
      physicians. It exposes its limitations, especially those related to minors'
      consent, living wills and research in people with mental disabilities. It also
      highlights positive aspects such as the promotion of a humane healthcare. This
      Law begins to consider patients' autonomy shyly. However, from a bioethical
      viewpoint, there are still many issues to be perfected such as healthcare
      humanization, excellence of patient care, healthcare quality and medical
      professionalism, considering competence, social service, charity and solidarity. 
      It is a first step that must be supplemented with a greater development of
      medical deontology, and the development of clinical and institutional bioethics.
FAU - Leon, Francisco Javier
AU  - Leon FJ
AD  - Centro de Bioetica, Facultad de Medicina, Pontificia Universidad Catolica de
      Chile, Santiago, Chile. fleonc@uc.cl
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Ley de derechos y deberes de las personas en la atencion de salud: Una mirada
      bioetica.
PL  - Chile
TA  - Rev Med Chil
JT  - Revista medica de Chile
JID - 0404312
SB  - IM
MH  - Bioethical Issues
MH  - Chile
MH  - Delivery of Health Care/*ethics/*legislation & jurisprudence
MH  - Disabled Persons/legislation & jurisprudence
MH  - Health Care Reform/ethics/legislation & jurisprudence
MH  - Humans
MH  - Patient Rights/*ethics/*legislation & jurisprudence
MH  - Professional-Patient Relations/ethics
EDAT- 2013/05/17 06:00
MHDA- 2013/11/16 06:00
CRDT- 2013/05/17 06:00
PHST- 2012/07/23 00:00 [received]
PHST- 2012/10/17 00:00 [accepted]
PHST- 2013/05/17 06:00 [entrez]
PHST- 2013/05/17 06:00 [pubmed]
PHST- 2013/11/16 06:00 [medline]
AID - S0034-98872012001100017 [pii]
AID - 10.4067/S0034-98872012001100017 [doi]
PST - ppublish
SO  - Rev Med Chil. 2012 Nov;140(11):1490-4. doi: 10.4067/S0034-98872012001100017.


PMID- 23671958
OWN - NLM
STAT- MEDLINE
DCOM- 20130910
LR  - 20130515
IS  - 2676-1319 (Print)
IS  - 2676-1319 (Linking)
VI  - 14
IP  - 2
DP  - 2012 Jun
TI  - Redo-laparotomies: reasons, morbidity and outcome.
PG  - 107-10
AB  - A large number of patients undergo various operative procedures every day and
      laparotomy forms a large proportion. At times, laparotomies have to be redone due
      to complications like biliary peritonitis, faecal fistula, burst abdomen or
      anastomotic leak. Our objectives were to determine the causes of Redo-laparotomy 
      evaluate morbidity associated with it and analyze its outcome. A prospective
      study of patients in BP Koirala Institute of Health Sciences (BPKIHS) from 1. 1. 
      2009 to 31. 12. 2009 was done. Institutional ethical clearance was taken. The
      Statistical analyses were done using SPSS version 11.5. Redo-laparotomy was
      performed in 40(1.99%) cases. The mean age was 31.99 +/- 21.49 years with a M: F 
      ratio of 4:3. The indications of Redo-laparotomy were: burst abdomen (n = 9;
      22.5%), followed by intra-abdominal collection and abscess (n = 7; 17.5%), fecal 
      (n = 6; 15%), and biliary peritonitis (n = 5; 12.5%). The mean duration between
      first laparotomy and Redo was 9.42 +/- 7.56 days and the mean duration of
      hospitalization was 26.98 +/- 12.50 days. Lower gastrointestinal surgeries
      usually lead to a Redo. The mortality in our study was 30% and 21/40 patients had
      to be managed in the intensive care unit. Clinical acumen formed the basis
      (87.5%) to decide for Redo-laparotomy in the majority. Redo-laparotomies that are
      performed following complicated abdominal surgeries have high morbidity and
      mortality rates. Multiple factors may lead to a Redo-laparotomy which is beyond
      the hands of a clinician yet a vigilant and vigorous management could help reduce
      the rate of Redo-laparotomies.
FAU - Koirala, R
AU  - Koirala R
AD  - Department of Surgery, Nepal Medical College Teaching Hospital, Jorpati,
      Kathmandu, Nepal. rabinkoirala@hotmail.com
FAU - Shakya, V C
AU  - Shakya VC
FAU - Khania, S
AU  - Khania S
FAU - Adhikary, S
AU  - Adhikary S
FAU - Agrawal, C S
AU  - Agrawal CS
LA  - eng
PT  - Journal Article
PL  - Nepal
TA  - Nepal Med Coll J
JT  - Nepal Medical College journal : NMCJ
JID - 101129937
SB  - IM
MH  - Abdominal Abscess/*surgery
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Female
MH  - Humans
MH  - Intestinal Diseases/*surgery
MH  - Male
MH  - Middle Aged
MH  - Peritonitis/*surgery
MH  - Postoperative Complications/*surgery
MH  - Prospective Studies
MH  - Reoperation/*mortality
MH  - Rupture, Spontaneous
MH  - Young Adult
EDAT- 2013/05/16 06:00
MHDA- 2013/09/11 06:00
CRDT- 2013/05/16 06:00
PHST- 2013/05/16 06:00 [entrez]
PHST- 2013/05/16 06:00 [pubmed]
PHST- 2013/09/11 06:00 [medline]
PST - ppublish
SO  - Nepal Med Coll J. 2012 Jun;14(2):107-10.


PMID- 23662108
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1741-0541 (Print)
IS  - 1741-0541 (Linking)
VI  - 9
IP  - 4
DP  - 2012 Jun 1
TI  - After the revolution? Ethical and social challenges in 'personalized genomic
      medicine'
PG  - 429-439
AB  - Personalized genomic medicine (PGM) is a goal that currently unites a wide array 
      of biomedical initiatives, and is promoted as a 'new paradigm for healthcare' by 
      its champions. Its promissory virtues include individualized diagnosis and risk
      prediction, more effective prevention and health promotion, and patient
      empowerment. Beyond overcoming scientific and technological hurdles to realizing 
      PGM, proponents may interpret and rank these promises differently, which carries 
      ethical and social implications for the realization of PGM as an approach to
      healthcare. We examine competing visions of PGM's virtues and the directions in
      which they could take the field, in order to anticipate policy choices that may
      lie ahead for researchers, healthcare providers and the public.
FAU - Juengst, Eric T
AU  - Juengst ET
AD  - University of North Carolina - Chapel Hill, Center for Bioethics, 333 MacNider
      Hall, Chapel Hill, NC 27599-7240, USA.
FAU - Settersten, Richard A Jr
AU  - Settersten RA Jr
FAU - Fishman, Jennifer R
AU  - Fishman JR
FAU - McGowan, Michelle L
AU  - McGowan ML
LA  - eng
GR  - R01 HG005277/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PL  - England
TA  - Per Med
JT  - Personalized medicine
JID - 101238549
PMC - PMC3646379
MID - NIHMS405016
OTO - NOTNLM
OT  - empowerment
OT  - participatory
OT  - personalization
OT  - prediction
OT  - prevention
OT  - social worlds
OT  - stakeholders
EDAT- 2013/05/11 06:00
MHDA- 2013/05/11 06:01
CRDT- 2013/05/11 06:00
PHST- 2013/05/11 06:00 [entrez]
PHST- 2013/05/11 06:00 [pubmed]
PHST- 2013/05/11 06:01 [medline]
AID - 10.2217/pme.12.37 [doi]
PST - ppublish
SO  - Per Med. 2012 Jun 1;9(4):429-439. doi: 10.2217/pme.12.37.


PMID- 23661883
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130513
LR  - 20211021
IS  - 0300-1652 (Print)
IS  - 0300-1652 (Linking)
VI  - 53
IP  - 4
DP  - 2012 Oct
TI  - Knowledge of medical ethics among Nigerian medical doctors.
PG  - 226-30
LID - 10.4103/0300-1652.107600 [doi]
AB  - BACKGROUND: The knowledge of medical ethics is essential for health care
      practitioners worldwide. The main objective of this study was to evaluate the
      knowledge of medical doctors in a tertiary care hospital in Nigeria in the area
      of medical ethics. MATERIALS AND METHODS: A cross-sectional questionnaire-based
      study involving 250 medical doctors of different levels was carried out. The
      questionnaire, apart from the bio-data, also sought information on undergraduate 
      and postgraduate training in medical ethics, knowledge about the principles of
      biomedical ethics and the ethical dilemmas encountered in daily medical practice.
      RESULTS: One hundred and ninety (190) respondents returned the filled
      questionnaire representing a response rate of 76%. One hundred and fifty-two
      respondents (80%) have had some sort of medical ethics education during their
      undergraduate level in the medical education. The median duration of formal
      training or exposure to medical ethics education was 3.00 hours (range: 0-15).
      One hundred and twenty-nine respondents have read at least once the code of
      medical ethics of the Medical and Dental Council of Nigeria while 127 (66.8%)
      have some general knowledge of the principles of biomedical ethics. The breakdown
      of the identified ethical dilemmas shows that discharge against medical advice
      was the most identified by the respondents (69.3%) followed by religious/cultural
      issues (56.6%) while confidentiality was recognized by 53.4%. CONCLUSION: The
      knowledge of medical ethics by Nigerian medical doctors is grossly inadequate.
      There is an urgent need for enhancement of the teaching of the discipline at both
      undergraduate and postgraduate levels in Nigeria.
FAU - Fadare, Joseph O
AU  - Fadare JO
AD  - Department of Medical Pharmacology and Therapeutics, Obafemi Awolowo University, 
      Ile-Ife, Nigeria.
FAU - Desalu, Olufemi O
AU  - Desalu OO
FAU - Jemilohun, Abiodun C
AU  - Jemilohun AC
FAU - Babatunde, Oluwole A
AU  - Babatunde OA
LA  - eng
PT  - Journal Article
PL  - Nigeria
TA  - Niger Med J
JT  - Nigerian medical journal : journal of the Nigeria Medical Association
JID - 0315137
PMC - PMC3640244
OTO - NOTNLM
OT  - Biomedical ethics
OT  - developing countries
OT  - ethical dilemma
OT  - medical education
OT  - physicians
EDAT- 2013/05/11 06:00
MHDA- 2013/05/11 06:01
CRDT- 2013/05/11 06:00
PHST- 2013/05/11 06:00 [entrez]
PHST- 2013/05/11 06:00 [pubmed]
PHST- 2013/05/11 06:01 [medline]
AID - 10.4103/0300-1652.107600 [doi]
AID - NMJ-53-226 [pii]
PST - ppublish
SO  - Niger Med J. 2012 Oct;53(4):226-30. doi: 10.4103/0300-1652.107600.


PMID- 23661880
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130513
LR  - 20211021
IS  - 0300-1652 (Print)
IS  - 0300-1652 (Linking)
VI  - 53
IP  - 4
DP  - 2012 Oct
TI  - Nonconsensual sexual relationship and prevalence of HIV infection in adolescent
      in Jos, Nigeria.
PG  - 210-2
LID - 10.4103/0300-1652.107555 [doi]
AB  - BACKGROUND: HIV infection in adolescents is promoted by sexual risky behaviours
      and nonconsensual sex. Nonconsensual sex ranges from forced sex/rape, unwanted
      touch and inducement by gifts. This study was designed to determine the
      prevalence of nonconsensual sex (NCS) and HIV infection in adolescents. MATERIALS
      AND METHODS: Eight hundred and eighty three adolescents from 10 secondary schools
      were randomly selected and given a questionnaire to fill. All had group pre-test 
      counseling had HIV screening. HIV positive subjects had a confirmatory test done 
      after individual post-test counseling. Ethical clearance was received from the
      relevant authorities and persons. RESULTS: Of the 883 students, 169 (19.2%) were 
      sexually experienced. Of which 101/169 (59.8%) were males and 40.2% females. Mean
      age at first sexual debut was 14.4+/-2.6 years; males 13.3+/-2.7 years and
      females 14.6+/-3.2 years, P=0.006. Seventy three of 127 respondents (57.5%)
      indicated consensual sex and 42.5% (54/127) indicated NCS. Of the 54 subjects,
      74% were females and 22% males. Mean age at first sex in NCS was 13.5 + 3.4 yrs; 
      males, 12.5+/-2.9 yr in NCS and 14+/-2.6 in consensual, P=0.045; females 14+/-3.5
      in NCS and 16.5+/-1.2 in consensual P=0.02. Circumstances of sex showed 59.3%
      were forced sex or rape, 7.4% was following gifts. Over 70% of NCS group use no
      form of protection. In the population studied 9/883 (1.02%) were HIV positive.
      Among the sexually experienced HIV prevalence was 2.4% (4/169), and 3.7% (2/54)
      among NCS. CONCLUSION: Prevalence of NCS is high, occurring at an earlier age and
      associated with lack of condom use as well as a higher HIV prevalence.
FAU - John, Collins
AU  - John C
AD  - Department of Paediatrics, Jos University Teaching Hospital, Jos, Plateau State, 
      Nigeria.
FAU - Okolo, Seline N
AU  - Okolo SN
FAU - Isichei, Chris
AU  - Isichei C
LA  - eng
PT  - Journal Article
PL  - Nigeria
TA  - Niger Med J
JT  - Nigerian medical journal : journal of the Nigeria Medical Association
JID - 0315137
PMC - PMC3640241
OTO - NOTNLM
OT  - Adolescents
OT  - human immunodeficiency virus infection
OT  - nonconsensual sex
EDAT- 2013/05/11 06:00
MHDA- 2013/05/11 06:01
CRDT- 2013/05/11 06:00
PHST- 2013/05/11 06:00 [entrez]
PHST- 2013/05/11 06:00 [pubmed]
PHST- 2013/05/11 06:01 [medline]
AID - 10.4103/0300-1652.107555 [doi]
AID - NMJ-53-210 [pii]
PST - ppublish
SO  - Niger Med J. 2012 Oct;53(4):210-2. doi: 10.4103/0300-1652.107555.


PMID- 23648201
OWN - NLM
STAT- MEDLINE
DCOM- 20130613
LR  - 20130507
IS  - 0393-974X (Print)
IS  - 0393-974X (Linking)
VI  - 26
IP  - 2 Suppl 1
DP  - 2012 Apr-Jun
TI  - Treatment of knee chondropathy with platelet rich plasma. Preliminary results at 
      6 months of follow-up with only one injection.
PG  - 71S-78S
AB  - Application of new biological treatments in orthopaedics is controversial
      nowadays. Surgeons and practitioners know how difficult can be to choose a
      solution for chondral injuries. Joint damages are from little contusions,
      osteochondral fractures, avascular necrosis, osteochondritis and degenerative
      processes like osteoarthritis and rheumatisms. All mentioned have a common
      problem: the lack of regenerating hyaline cartilage by themselves. Recently, PRP 
      have been used to treat early moderate chondropathies. Here we show the
      preliminary results of 30 patients affected by chondropathy of the knee after 6
      months treated with a single intrarticular injection of PRP. Thirty patients,
      18-65 years old, with a diagnosis of I to III Outerbridge chondropathy in the
      knee, pain for more than 3 months following conservative treatment and no bone
      axial defect, were treated with one intraarticular injection of PRP (GPS mini
      set, BIOMET), after written consent and Ethic and Legal Committee approval. VAS
      and KOOS scores were evaluated before PRP injection and at 1, 3 and 6 months
      after the treatment. ANOVA with repeated measures using the SPSS showed
      significantly better results in term of KOOS and VAS scores at 1, 3 and 6 months 
      respect to the pre-injection value (p less than 0,05) We think that PRP treatment
      is a promising alternative for the treatment of knee chondropathy; however its
      efficacy has to be demonstrated with more clinical works, with longer follow up
      and with greater number of patients, even with controlled and randomized trials. 
      In our study only one injection of PRP has been able to allow a clinical
      improvement, suggesting the possibility to avoid multiple injections protocols,
      and consequently reducing the health expenses. Until the efficacy of PRP will not
      be definitely demonstrated, surgeon should be very prudent in indications.
FAU - Torrero, J I
AU  - Torrero JI
AD  - Orthopaedic and Trauma Unit, Nostra Senyora de Meritxell Hospital, Principality
      of Andorra. jtorrero@saas.ad
FAU - Aroles, F
AU  - Aroles F
FAU - Ferrer, D
AU  - Ferrer D
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - J Biol Regul Homeost Agents
JT  - Journal of biological regulators and homeostatic agents
JID - 8809253
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cartilage, Articular/*pathology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Injections, Intra-Articular/*methods
MH  - Knee Joint/*pathology
MH  - Male
MH  - Middle Aged
MH  - Osteoarthritis, Knee/pathology/*therapy
MH  - Osteochondritis/pathology/*therapy
MH  - Pain Measurement
MH  - Platelet-Rich Plasma/*chemistry/cytology
MH  - Research Design
MH  - Treatment Outcome
EDAT- 2013/05/08 06:00
MHDA- 2013/06/14 06:00
CRDT- 2013/05/08 06:00
PHST- 2013/05/08 06:00 [entrez]
PHST- 2013/05/08 06:00 [pubmed]
PHST- 2013/06/14 06:00 [medline]
AID - 8 [pii]
PST - ppublish
SO  - J Biol Regul Homeost Agents. 2012 Apr-Jun;26(2 Suppl 1):71S-78S.


PMID- 23638277
OWN - NLM
STAT- MEDLINE
DCOM- 20140212
LR  - 20211021
IS  - 1995-7270 (Electronic)
IS  - 1995-7262 (Linking)
VI  - 24
IP  - 3
DP  - 2012 Sep
TI  - View point: Ethical dilemmas in malaria vector research in Africa: making the
      difficult choice between mosquito, science and humans.
PG  - 65-8
AB  - Malaria vector studies are a very important aspect of malaria research as they
      assist researchers to learn more about the malaria vector. Research programmes in
      various African countries include studies that assess various methods of
      preventing malaria transmission including controlling the malaria vector. Various
      institutions have also established mosquito colonies that are maintained by staff
      from the institutions. Malaria vector research presents several dilemmas relating
      to the various ways in which humans are used in the malaria vector research
      enterprise. A review of the past and present practices reveals much about the
      prevailing attitudes and assumptions with regard to the ethical conduct of
      research involving humans. The focus on the science of malaria vector research
      has led some researchers in African institutions to engage in questionable
      practices which reveal the ethical tensions inherent in the choice between
      science and the principles of justice, nonmaleficence and respect for
      individuals. The analysis of past and present choices in malaria vector research 
      has relevance to broader questions of human dignity and are in line with the
      current emphasis on ethical research worldwide.
FAU - Ndebele, P
AU  - Ndebele P
AD  - HJF-DAIDS, Bethesda, USA.
FAU - Musesengwa, R
AU  - Musesengwa R
LA  - eng
PT  - Journal Article
PL  - Malawi
TA  - Malawi Med J
JT  - Malawi medical journal : the journal of Medical Association of Malawi
JID - 9500170
SB  - IM
MH  - Animals
MH  - Biomedical Research/*ethics
MH  - *Culicidae
MH  - Humans
MH  - Malaria/*prevention & control/*transmission
MH  - Mosquito Control/*ethics/methods
PMC - PMC3576825
EDAT- 2013/05/03 06:00
MHDA- 2014/02/13 06:00
CRDT- 2013/05/03 06:00
PHST- 2013/05/03 06:00 [entrez]
PHST- 2013/05/03 06:00 [pubmed]
PHST- 2014/02/13 06:00 [medline]
PST - ppublish
SO  - Malawi Med J. 2012 Sep;24(3):65-8.


PMID- 23634159
OWN - NLM
STAT- MEDLINE
DCOM- 20140725
LR  - 20211021
IS  - 1715-6580 (Electronic)
IS  - 1715-6572 (Linking)
VI  - 7
IP  - 4
DP  - 2012 May
TI  - Making Canada a destination for medical tourists: why Canadian provinces should
      not try to become "Mayo Clinics of the North".
PG  - 18-25
AB  - When Canadian researchers examine the subject of medical tourism, they typically 
      focus on ethical, social, public health and health policy issues related to
      Canadians seeking health services in other countries. They emphasize study of
      Canada as a departure point for medical tourists rather than as a potential
      destination for international patients. Several influential voices have recently 
      argued that provincial healthcare systems in Canada should market health services
      to international patients. Proponents of marketing Canada as a destination for
      medical tourists argue that attracting international patients will generate
      revenue for provincial healthcare systems. Responding to such proposals, I argue 
      that there are at least seven reasons why provincial health systems in Canada
      should not dedicate institutional, financial and health human resources to
      promoting themselves as destinations for medical tourists.
FAU - Turner, Leigh
AU  - Turner L
AD  - Associate Professor, Center for Bioethics, School of Public Health & College of
      Pharmacy, University of Minnesota, Minneapolis, MN, USA. turne462@umn.edu
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Healthc Policy
JT  - Healthcare policy = Politiques de sante
JID - 101280107
SB  - IM
MH  - Canada
MH  - Continuity of Patient Care
MH  - Health Facilities, Proprietary
MH  - Health Services Needs and Demand
MH  - Healthcare Disparities
MH  - Humans
MH  - *Medical Tourism
MH  - Patient Safety
MH  - Resource Allocation
PMC - PMC3359081
EDAT- 2013/05/02 06:00
MHDA- 2014/07/26 06:00
CRDT- 2013/05/02 06:00
PHST- 2013/05/02 06:00 [entrez]
PHST- 2013/05/02 06:00 [pubmed]
PHST- 2014/07/26 06:00 [medline]
PST - ppublish
SO  - Healthc Policy. 2012 May;7(4):18-25.


PMID- 23633902
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130502
LR  - 20211021
IS  - 1205-7088 (Print)
IS  - 1205-7088 (Linking)
VI  - 17
IP  - 5
DP  - 2012 May
TI  - Paediatricians, social media and blogs: Ethical considerations.
PG  - 267-72
AB  - The use of blogs, Facebook and similar social networking sites is rapidly
      expanding and, when compared with e-mail, may be having a significantly different
      impact on the traditional doctor-patient relationship. Characteristics specific
      to these online platforms have major implications for professional relationships,
      including the 'Facebook effect' (the relative permanence of postings) and the
      'online disinhibition effect'. The present practice point illustrates relevant
      ethical considerations and provides guidance to paediatricians and others
      concerning the prudent professional and personal use of social networking media.
FAU - St-Laurent-Gagnon, Therese
AU  - St-Laurent-Gagnon T
FAU - Coughlin, Kevin W
AU  - Coughlin KW
CN  - Canadian Paediatric Society, Bioethics Committee
LA  - eng
LA  - fre
PT  - Journal Article
PL  - England
TA  - Paediatr Child Health
JT  - Paediatrics & child health
JID - 9815960
PMC - PMC3381922
OTO - NOTNLM
OT  - Blogs
OT  - Ethics
OT  - Facebook
OT  - Paediatricians
OT  - Professionalism
OT  - Social networking
EDAT- 2013/05/02 06:00
MHDA- 2013/05/02 06:01
CRDT- 2013/05/02 06:00
PHST- 2013/05/02 06:00 [entrez]
PHST- 2013/05/02 06:00 [pubmed]
PHST- 2013/05/02 06:01 [medline]
AID - 10.1093/pch/17.5.267 [doi]
PST - ppublish
SO  - Paediatr Child Health. 2012 May;17(5):267-72. doi: 10.1093/pch/17.5.267.


PMID- 23633709
OWN - NLM
STAT- MEDLINE
DCOM- 20130702
LR  - 20211021
IS  - 0008-5286 (Print)
IS  - 0008-5286 (Linking)
VI  - 53
IP  - 11
DP  - 2012 Nov
TI  - Veterinary medical ethics. An ethicist's commentary on prolonging the life of
      cancer patient.
PG  - 1154-5
FAU - Rollin, Bernard E
AU  - Rollin BE
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Vet J
JT  - The Canadian veterinary journal = La revue veterinaire canadienne
JID - 0004653
SB  - IM
CIN - Can Vet J. 2013 Jan;54(1):10. PMID: 23814294
CIN - Can Vet J. 2013 Jan;54(1):12. PMID: 23814296
MH  - Animal Welfare
MH  - Animals
MH  - Canada
MH  - Euthanasia, Animal
MH  - Neoplasms/psychology/*veterinary
MH  - Pain/epidemiology/*veterinary
MH  - *Pets
MH  - *Quality of Life
MH  - Veterinary Medicine/*ethics
PMC - PMC3474570
EDAT- 2013/05/02 06:00
MHDA- 2013/07/03 06:00
CRDT- 2013/05/02 06:00
PHST- 2013/05/02 06:00 [entrez]
PHST- 2013/05/02 06:00 [pubmed]
PHST- 2013/07/03 06:00 [medline]
PST - ppublish
SO  - Can Vet J. 2012 Nov;53(11):1154-5.


PMID- 23630410
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1050-8422 (Print)
IS  - 1050-8422 (Linking)
VI  - 22
IP  - 6
DP  - 2012 Nov 1
TI  - The Legacy of the U. S. Public Health Services Study of Untreated Syphilis in
      African American Men at Tuskegee on the Affordable Care Act and Health Care
      Reform Fifteen Years After President Clinton's Apology.
PG  - 411-418
AB  - This special issue addresses the legacy of the United States Public Health
      Service Syphilis Study on health reform, particularly the Affordable Care Act
      (ACA). The 12 manuscripts cover the history and current practices of ethical
      abuses affecting American Indians, Latinos, Asian Americans and African Americans
      in the United States and in one case, internationally. Commentaries and essays
      include the voice of a daughter of one of the study participants in which we
      learn of the stigma and maltreatment some of the families experienced and how the
      study has impacted generations within the families. Consideration is given in one
      essay to utilizing narrative storytelling with the families to help promote
      healing. This article provides the reader a roadmap to the themes that emerged
      from the collection of articles. These themes include population versus
      individual consent issues, need for better government oversight in research and
      health care, the need for overhauling our bioethics training to develop a
      population level, culturally driven approach to research bioethics. The articles 
      challenge and inform us that some of our assumptions about how the consent
      process best works to protect racial/ethnic minorities may be merely assumptions 
      and not proven facts. Articles challenge the belief that low participation rates 
      seen in biomedical studies have resulted from the legacy of the USPHS Syphilis
      Study rather than a confluence of factors rooted in racism, bias and negative
      treatment. Articles in this special issue challenge the "cultural paranoia" of
      mistrust and provide insights into how the distrust may serve to lengthen rather 
      than shorten the lives of racial/ethnic minorities who have been used as guinea
      pigs on more than one occasion. We hope that the guidance offered on the
      importance of developing a new framework to bioethics can be integrated into the 
      foundation of health care reform.
FAU - Mays, Vickie M
AU  - Mays VM
AD  - Professor of Psychology and Health Services, Director, UCLA Center on Bridging
      Research, Innovation, Training and Education for Minority Health Disparities
      Solutions.
LA  - eng
GR  - P60 MD000508/MD/NIMHD NIH HHS/United States
GR  - P60 MD006923/MD/NIMHD NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Ethics Behav
JT  - Ethics & behavior
JID - 9102086
PMC - PMC3636721
MID - NIHMS458524
OTO - NOTNLM
OT  - Tuskegee
OT  - research bioethics
OT  - survivors
EDAT- 2013/05/01 06:00
MHDA- 2013/05/01 06:01
CRDT- 2013/05/01 06:00
PHST- 2013/05/01 06:00 [entrez]
PHST- 2013/05/01 06:00 [pubmed]
PHST- 2013/05/01 06:01 [medline]
AID - 10.1080/10508422.2012.730808 [doi]
PST - ppublish
SO  - Ethics Behav. 2012 Nov 1;22(6):411-418. doi: 10.1080/10508422.2012.730808.


PMID- 23620651
OWN - NLM
STAT- MEDLINE
DCOM- 20130627
LR  - 20211021
IS  - 1128-2460 (Print)
IS  - 1128-2460 (Linking)
VI  - 31
IP  - 3
DP  - 2012 Dec
TI  - Next generation sequencing (NGS) strategies for the genetic testing of
      myopathies.
PG  - 196-200
AB  - Next generation sequencing (NGS) technologies offer the possibility to map entire
      genomes at affordable costs. This brings the genetic testing procedure to a
      higher level of complexity. The positive aspect is the ease to cope with the
      complex diagnosis of genetically heterogeneous disorders and to identify novel
      disease genes. Worries arise from the management of too many DNA variations with 
      unpredictable meaning and incidental findings that can cause ethical and clinical
      dilemmas. The technology of enrichment makes possible to focus the sequencing to 
      the exome or to a more specific DNA target. This is being used to provide
      insights into the genetics underlying Mendelian traits involved in myopathies and
      to set up cost-effective diagnostic tests. This huge potential of the NGS
      applications makes likely that these will soon become the first approach in
      genetic diagnostic laboratories.
FAU - Nigro, Vincenzo
AU  - Nigro V
AD  - Telethon Institute of Genetics and Medicine, Naples, Italy.
      vincenzo.nigro@unina2.it
FAU - Piluso, Giulio
AU  - Piluso G
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Acta Myol
JT  - Acta myologica : myopathies and cardiomyopathies : official journal of the
      Mediterranean Society of Myology
JID - 9811169
RN  - 0 (Dystrophin)
SB  - IM
MH  - Dystrophin/genetics
MH  - *High-Throughput Nucleotide Sequencing/methods
MH  - Humans
MH  - Muscular Diseases/diagnosis/*genetics
MH  - Muscular Dystrophy, Facioscapulohumeral/genetics
MH  - *Sequence Analysis, DNA/methods
PMC - PMC3631804
OTO - NOTNLM
OT  - NGS
OT  - Next generation sequencing
OT  - neuromuscular disorders
EDAT- 2013/04/27 06:00
MHDA- 2013/06/29 06:00
CRDT- 2013/04/27 06:00
PHST- 2013/04/27 06:00 [entrez]
PHST- 2013/04/27 06:00 [pubmed]
PHST- 2013/06/29 06:00 [medline]
PST - ppublish
SO  - Acta Myol. 2012 Dec;31(3):196-200.


PMID- 23617986
OWN - NLM
STAT- MEDLINE
DCOM- 20130903
LR  - 20211021
IS  - 1920-7476 (Electronic)
IS  - 0008-4263 (Linking)
VI  - 103
IP  - 5
DP  - 2012 Jul 18
TI  - Restrictive measures in an influenza pandemic: a qualitative study of public
      perspectives.
PG  - e348-52
AB  - OBJECTIVES: Recent experiences have demonstrated that restrictive measures remain
      a useful public health tool during infectious disease outbreaks. However, the use
      of restrictive measures is not without controversy, as there is no agreed-upon
      threshold for when and how to invoke restrictive measures. The objectives of this
      study are to solicit perspectives from Canadians on the ethical considerations of
      using restrictive measures in response to influenza pandemics, and in turn, to
      use public views to contribute to a better understanding of what is considered to
      be the justifiable use of restrictive measures. METHODS: A series of town hall
      focus groups with Canadian residents from June 2008 to May 2009, in three
      Canadian regions, in order to achieve broad public engagement (n=3 focus groups
      with a total of 17 participants). RESULTS: Two key themes emerged from all town
      hall focus groups: 1) create an environment for compliance through communication 
      rather than enforcement, and 2) establish the delineation between individual
      rights, community values, and the greater good. CONCLUSION: While there is a need
      for a decision-making authority and even a mechanism for enforcement, our data
      suggest that a more tractable approach to restrictive measures is one that
      enables individuals to voluntarily comply by creating an environment to compel
      compliance based on communication. This approach requires restrictive measures to
      be a) proportional to the threat, b) implemented along with reciprocal
      arrangements provided to those affected, and c) accompanied by open and
      transparent communication throughout all stages so that citizens can both
      understand and participate in decision-making.
FAU - Smith, Maxwell J
AU  - Smith MJ
AD  - Joint Centre for Bioethics and Dalla Lana School of Public Health, University of 
      Toronto, Toronto, ON. max.smith@utoronto.ca
FAU - Bensimon, Cecile M
AU  - Bensimon CM
FAU - Perez, Daniel F
AU  - Perez DF
FAU - Sahni, Sachin S
AU  - Sahni SS
FAU - Upshur, Ross E G
AU  - Upshur RE
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120718
PL  - Switzerland
TA  - Can J Public Health
JT  - Canadian journal of public health = Revue canadienne de sante publique
JID - 0372714
SB  - IM
MH  - Canada
MH  - *Communication
MH  - Focus Groups
MH  - Humans
MH  - Influenza, Human/epidemiology/*prevention & control
MH  - Pandemics/*prevention & control
MH  - Public Health Practice/*ethics
MH  - *Public Opinion
MH  - Qualitative Research
PMC - PMC6973992
OTO - NOTNLM
OT  - Bioethics
OT  - Influenza
OT  - Pandemics
OT  - Public Health
OT  - Qualitative Research
OT  - Quarantine
EDAT- 2013/04/27 06:00
MHDA- 2013/09/04 06:00
CRDT- 2013/04/27 06:00
PHST- 2011/12/14 00:00 [received]
PHST- 2012/06/14 00:00 [accepted]
PHST- 2012/07/26 00:00 [revised]
PHST- 2013/04/27 06:00 [entrez]
PHST- 2013/04/27 06:00 [pubmed]
PHST- 2013/09/04 06:00 [medline]
PST - epublish
SO  - Can J Public Health. 2012 Jul 18;103(5):e348-52.


PMID- 23600047
OWN - NLM
STAT- MEDLINE
DCOM- 20130827
LR  - 20191112
IS  - 0250-636X (Print)
IS  - 0250-636X (Linking)
VI  - 33
IP  - 3
DP  - 2012 Jul-Sep
TI  - Learning curve, diagnostic yield and safety of single balloon enteroscopy.
PG  - 179-84
AB  - BACKGROUND: Single balloon enteroscopy (SBE) is a recently developed diagnostic
      modality to assess small bowel mucosa. The data on learning curve of SBE is
      scanty. We aimed to assess the learning curve, diagnostic yield and safety of
      SBE. METHODS: All patients who underwent SBE at our centre from December 2007 to 
      December 2010 were included retrospectively. The clinical details, enteroscopy
      findings and procedure related details were obtained for each patient from a
      prospectively maintained database. The extent of small bowel visualised with
      increasing number of procedures by a single endoscopist (Endoscopist A) who
      performed most of the procedures was used to estimate the learning curve using
      locally weighted regression curve. The diagnostic yield and complications rates
      of SBE were also estimated. The study was approved by the institute review board 
      and ethics committee. RESULTS: Ninety SBEs were performed in 84 patients (age:
      42+15 years, 27.4% females). 57 procedures were performed (32 antegrade and 25
      retrograde) by endoscopist A. There was gradual improvement in the extent of
      small bowel visualised during the first 15 procedures via antegrade route
      followed by flattening of curve. The retrograde route showed no definite trend
      towards improvement during the procedures performed. The overall diagnostic yield
      of SBE was 32.1%. There was no complication except for mild self-limiting
      abdominal pain in one patient. CONCLUSIONS: SBE via antegrade route has a higher 
      success rate and better learning curve than the retrograde route. SBE is a safe
      procedure and helps in establishing a diagnosis in one-third of the patients
      examined.
FAU - Dutta, Amit Kumar
AU  - Dutta AK
AD  - Department of Gastrointestinal Sciences, Christian Medical College and Hospital, 
      Vellore - 632 004, Tamil Nadu, India.
FAU - Sajith, Kattiparambil Gangadharan
AU  - Sajith KG
FAU - Joseph, Anjilivelil J
AU  - Joseph AJ
FAU - Simon, Ebby George
AU  - Simon EG
FAU - Chacko, Ashok
AU  - Chacko A
LA  - eng
PT  - Journal Article
PL  - India
TA  - Trop Gastroenterol
JT  - Tropical gastroenterology : official journal of the Digestive Diseases Foundation
JID - 8107122
SB  - IM
MH  - Abdominal Pain/diagnosis/etiology
MH  - Adult
MH  - Crohn Disease/diagnosis
MH  - Endoscopy, Gastrointestinal/adverse effects/*methods
MH  - Female
MH  - Gastrointestinal Hemorrhage/*diagnosis/etiology
MH  - Humans
MH  - *Intestine, Small
MH  - *Learning Curve
MH  - Malabsorption Syndromes/diagnosis
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
EDAT- 2013/04/23 06:00
MHDA- 2013/08/28 06:00
CRDT- 2013/04/23 06:00
PHST- 2013/04/23 06:00 [entrez]
PHST- 2013/04/23 06:00 [pubmed]
PHST- 2013/08/28 06:00 [medline]
AID - 10.7869/tg.2012.45 [doi]
PST - ppublish
SO  - Trop Gastroenterol. 2012 Jul-Sep;33(3):179-84. doi: 10.7869/tg.2012.45.


PMID- 23598023
OWN - NLM
STAT- MEDLINE
DCOM- 20131029
LR  - 20131121
IS  - 1873-3573 (Electronic)
IS  - 0039-9140 (Linking)
VI  - 105
DP  - 2013 Feb 15
TI  - Detection of the marine toxin okadaic acid: assessing seafood safety.
PG  - 306-16
LID - 10.1016/j.talanta.2012.10.049 [doi]
LID - S0039-9140(12)00880-6 [pii]
AB  - Diarrheic Shellfish Poisoning (DSP) is a gastrointestinal illness caused by
      consumption of shellfish contaminated with DSP toxins such as okadaic acid (OA)
      and dinophysistoxins (DTX). The occurrences of OA in bivalves induce not only
      public health problems but also economic damages to shellfish farming.
      Consequently, the development of fast, reliable and sensitive detection methods
      is an evident necessity. The mouse bioassay has been the reference and most
      commonly used analysis method. However, this technique suffers from low accuracy,
      specificity and ethical problems due to the animal experimentation. Thus, the
      development of alternative and efficient detection systems is required. Several
      biological, chemical, and immunological methods have been developed to evaluate
      the presence of DSP toxins in seafood. This review gives an overview of different
      analytical methods and new trends for the detection of OA. Over the past decade, 
      considerable attention has been given to the development of biosensors for the
      efficient detection of marine toxin. Recent advances in the field of aptamers and
      nanomaterial offer exciting new opportunities to develop improved and more
      reliable devices allowing the detection of OA.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Sassolas, Audrey
AU  - Sassolas A
AD  - Universite de Perpignan, Laboratoire IMAGES, EA 4218, 52 avenue Paul Alduy, bat. 
      S, Perpignan cedex 66860, France. audrey.sassolas@univ-perp.fr
FAU - Hayat, Akhtar
AU  - Hayat A
FAU - Catanante, Gaelle
AU  - Catanante G
FAU - Marty, Jean-Louis
AU  - Marty JL
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121106
PL  - Netherlands
TA  - Talanta
JT  - Talanta
JID - 2984816R
RN  - 1W21G5Q4N2 (Okadaic Acid)
SB  - IM
MH  - Chromatography, Liquid
MH  - Electrophoresis, Capillary
MH  - *Marine Biology
MH  - Mass Spectrometry
MH  - Okadaic Acid/*toxicity
MH  - Seafood/*analysis
MH  - Spectrometry, Fluorescence
EDAT- 2013/04/20 06:00
MHDA- 2013/10/30 06:00
CRDT- 2013/04/20 06:00
PHST- 2012/06/06 00:00 [received]
PHST- 2012/10/10 00:00 [revised]
PHST- 2012/10/13 00:00 [accepted]
PHST- 2013/04/20 06:00 [entrez]
PHST- 2013/04/20 06:00 [pubmed]
PHST- 2013/10/30 06:00 [medline]
AID - S0039-9140(12)00880-6 [pii]
AID - 10.1016/j.talanta.2012.10.049 [doi]
PST - ppublish
SO  - Talanta. 2013 Feb 15;105:306-16. doi: 10.1016/j.talanta.2012.10.049. Epub 2012
      Nov 6.


PMID- 23596916
OWN - NLM
STAT- MEDLINE
DCOM- 20130620
LR  - 20191112
IS  - 0102-6933 (Print)
IS  - 0102-6933 (Linking)
VI  - 33
IP  - 4
DP  - 2012 Dec
TI  - [Child with HIV/AIDS: perception of the antiretroviral treatment].
PG  - 48-55
AB  - This article presents a cutting from the multicentric study carried out in the
      municipalities of Porto Alegre and Santa Maria/ RS with the objective of
      unveiling the perception and the life experience of the child regarding the
      antiretroviral treatment. With qualitative approach, the study was carried out
      with seven children of five to ten years of age, in the period from 2006 to 2010,
      after approval by Committee National for Ethics in research and the Committees of
      Ethics in research. Based on the thematic analysis was obtained the results: the 
      day-to-day life of the child with medicines; the family care upon the adhesion to
      the antiretroviral treatment; the professional care:perception of children with
      infection. Observation showed that the children face adversities, know and
      appreciate the treatment in spite of the paradoxical movement of
      rejection/acceptance expressed by the fight against the syndrome.
FAU - da Motta, Maria da Graca Corso
AU  - da Motta Mda G
AD  - Escola de Enfermagem e do Programa de Pos-Graduacao em Enfermagem da Universidade
      Federal do Rio Grande do Sul (UFRGS). mottinha@enf.ufrgs.br
FAU - Pedro, Eva Neri Rubim
AU  - Pedro EN
FAU - Neves, Eliane Tatsch
AU  - Neves ET
FAU - Issi, Helena Becker
AU  - Issi HB
FAU - Ribeiro, Nair Regina Ritter
AU  - Ribeiro NR
FAU - Wachholz, Neiva Isabel Raffo
AU  - Wachholz NI
FAU - Greff, Aramita Prates
AU  - Greff AP
FAU - Ribeiro, Aline Cammarano
AU  - Ribeiro AC
FAU - de Paula, Cristiane Cardoso
AU  - de Paula CC
FAU - Coelho, Debora Fernandes
AU  - Coelho DF
FAU - de Padoin, Stela Maris Mello
AU  - de Padoin SM
FAU - Kreitchmann, Regis
AU  - Kreitchmann R
FAU - Kruel, Aline Goulart
AU  - Kruel AG
FAU - Poletto, Paula Manoela Batista
AU  - Poletto PM
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Crianca com HIV/AIDS: percepcao do tratamento antirretroviral.
PL  - Brazil
TA  - Rev Gaucha Enferm
JT  - Revista gaucha de enfermagem
JID - 8504882
RN  - 0 (Anti-Retroviral Agents)
MH  - Acquired Immunodeficiency Syndrome/drug therapy/*psychology
MH  - *Anti-Retroviral Agents/therapeutic use
MH  - *Attitude to Health
MH  - Child
MH  - Child, Preschool
MH  - HIV Infections/drug therapy/psychology
MH  - Humans
EDAT- 2013/04/20 06:00
MHDA- 2013/06/21 06:00
CRDT- 2013/04/20 06:00
PHST- 2013/04/20 06:00 [entrez]
PHST- 2013/04/20 06:00 [pubmed]
PHST- 2013/06/21 06:00 [medline]
AID - 10.1590/s1983-14472012000400006 [doi]
PST - ppublish
SO  - Rev Gaucha Enferm. 2012 Dec;33(4):48-55. doi: 10.1590/s1983-14472012000400006.


PMID- 23576848
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 0950-5431 (Print)
IS  - 0950-5431 (Linking)
VI  - 21
IP  - 3
DP  - 2012 Sep
TI  - Anticipatory Governance: Bioethical Expertise for Human/Animal Chimeras.
PG  - 291-313
AB  - The governance demands generated by the use of human/animal chimeras in
      scientific research offer both a challenge and an opportunity for the development
      of new forms of anticipatory governance through the novel application of
      bioethical expertise. Anticipatory governance can be seen to have three stages of
      development whereby bioethical experts move from a reactive to a proactive stance
      at the edge of what is scientifically possible. In the process, the ethicists
      move upstream in their engagement with the science of human-to-animal chimeras.
      To what extent is the anticipatory coestablishment of the principles and
      operational rules of governance at this early stage in the development of the
      human-to-animal research field likely to result in a framework for bioethical
      decision making that is in support of science? The process of anticipatory
      governance is characterised by the entwining of the scientific and the
      philosophical so that judgements against science are also found to be
      philosophically unfounded, and conversely, those activities that are permissible 
      are deemed so on both scientific and ethical grounds. Through what is presented
      as an organic process, the emerging bioethical framework for human-to-animal
      chimera research becomes a legitimating framework within which 'good' science can
      safely progress. Science gives bioethical expertise access to new governance
      territory; bioethical expertise gives science access to political acceptability.
FAU - Harvey, Alison
AU  - Harvey A
AD  - King's College London, CBAS, London, UK.
FAU - Salter, Brian
AU  - Salter B
LA  - eng
GR  - 086034/Wellcome Trust/United Kingdom
PT  - Journal Article
DEP - 20120221
PL  - England
TA  - Sci Cult (Lond)
JT  - Science as culture
JID - 9883160
PMC - PMC3617809
OTO - NOTNLM
OT  - Bioethical expertise
OT  - anticipatory governance
OT  - good science
OT  - human/animal chimeras
EDAT- 2013/04/12 06:00
MHDA- 2013/04/12 06:01
CRDT- 2013/04/12 06:00
PHST- 2013/04/12 06:00 [entrez]
PHST- 2013/04/12 06:00 [pubmed]
PHST- 2013/04/12 06:01 [medline]
AID - 10.1080/09505431.2011.630069 [doi]
PST - ppublish
SO  - Sci Cult (Lond). 2012 Sep;21(3):291-313. doi: 10.1080/09505431.2011.630069. Epub 
      2012 Feb 21.


PMID- 23569705
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130410
LR  - 20211021
IS  - 2151-4585 (Print)
IS  - 2151-4585 (Linking)
VI  - 3
IP  - 3
DP  - 2012 Sep
TI  - Peridural Anesthesia or Ultrasound-Guided Continuous 3-in-1 Block: Which Is
      Indicated for Analgesia in Very Elderly Patients With Hip Fracture in the
      Emergency Department?
PG  - 121-8
LID - 10.1177/2151458512470953 [doi]
AB  - PURPOSE: The aim of our study was to investigate the clinical relevance of
      preoperative acute pain management and cardiovascular stability by
      ultrasound-guided continuous 3-in-1 nerve block in very elderly patients with hip
      fracture when compared to epidural anesthesia (PDA). METHODS: To study the
      analgesic effect, we enrolled 37 very elderly patients with hip fractures, of
      whom 3 patients with dementia had to be excluded. Thus, 34 patients were
      randomized to 1 of the 3 groups: group A (ultrasound-guided continuous 3-in-1
      block, bupivacaine; n = 10, dropout rate: 0), group B (PDA, bupivacaine; n = 14, 
      dropout rate: 8), and group C (systemic pain therapy, piritramide/paracetamol; n 
      = 10, dropout rate: 0). Pain intensity was assessed preoperatively and up to 24
      hours postoperatively using a visual analog scale, verbal rating scale, analgesic
      consumption, scale of well-being, and cardiocirculatory parameters (eg, serum
      troponin T). RESULTS: Our data show that in the preoperative period both regional
      anesthesia (RA) procedures (analgesia responders after 1 hour: 86.7% and 100%; P 
      = .001) were superior to systemic analgesia (analgesia responders: 46.7%), and
      the rescue medication requirement in the 2 RA groups was significantly lower (P =
      .02). Serum troponin T level increased only in the systemic analgesia group (P = 
      .04). In the emergency department, the disadvantage of PDA in geriatric patients 
      with hip fracture was the fact that procedures were more complex, resulting in a 
      high dropout rate (57.1%). The use of PDA has to be critically discussed for
      ethical concerns. CONCLUSION: In the specific situation of acute hospital
      admission, the ultrasound-guided continuous 3-in-1 block appears to be indicated 
      as a stress-free means of providing adequate preoperative pain relief in very
      elderly patients with hip fracture. However, these findings should be
      corroborated by studies involving larger numbers of patients.
FAU - Luger, Thomas J
AU  - Luger TJ
AD  - Department of Anesthesiology and Critical Care Medicine, Innsbruck Medical
      University, Innsbruck, Austria.
FAU - Kammerlander, Christian
AU  - Kammerlander C
FAU - Benz, Maureen
AU  - Benz M
FAU - Luger, Markus F
AU  - Luger MF
FAU - Garoscio, Ivo
AU  - Garoscio I
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Geriatr Orthop Surg Rehabil
JT  - Geriatric orthopaedic surgery & rehabilitation
JID - 101558150
PMC - PMC3598445
OTO - NOTNLM
OT  - analgesia
OT  - emergency
OT  - geriatrics
OT  - serum troponin T
OT  - ultrasound-guided continuous 3-in-1 block
EDAT- 2013/04/10 06:00
MHDA- 2013/04/10 06:01
CRDT- 2013/04/10 06:00
PHST- 2013/04/10 06:00 [entrez]
PHST- 2013/04/10 06:00 [pubmed]
PHST- 2013/04/10 06:01 [medline]
AID - 10.1177/2151458512470953 [doi]
AID - 10.1177_2151458512470953 [pii]
PST - ppublish
SO  - Geriatr Orthop Surg Rehabil. 2012 Sep;3(3):121-8. doi: 10.1177/2151458512470953.


PMID- 23565384
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130409
LR  - 20211021
IS  - 2230-8210 (Print)
IS  - 2230-9500 (Linking)
VI  - 16
IP  - Suppl 2
DP  - 2012 Dec
TI  - Stem cell therapy for diabetes.
PG  - S227-9
LID - 10.4103/2230-8210.104045 [doi]
AB  - Stem cell therapy holds immense promise for the treatment of patients with
      diabetes mellitus. Research on the ability of human embryonic stem cells to
      differentiate into islet cells has defined the developmental stages and
      transcription factors involved in this process. However, the clinical
      applications of human embryonic stem cells are limited by ethical concerns, as
      well as the potential for teratoma formation. As a consequence, alternative forms
      of stem cell therapies, such as induced pluripotent stem cells, umbilical cord
      stem cells and bone marrow-derived mesenchymal stem cells, have become an area of
      intense study. Recent advances in stem cell therapy may turn this into a
      realistic treatment for diabetes in the near future.
FAU - Lee, K O
AU  - Lee KO
AD  - Department of Medicine, National University of Singapore, Singapore.
FAU - Gan, S U
AU  - Gan SU
FAU - Calne, R Y
AU  - Calne RY
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Endocrinol Metab
JT  - Indian journal of endocrinology and metabolism
JID - 101555690
EIN - Indian J Endocrinol Metab. 2013 Jan;17(1):162. PMID: 23776873
PMC - PMC3603032
OTO - NOTNLM
OT  - Embryonic stem cell
OT  - diabetes
OT  - induced pluripotent stem cell
OT  - mesenchymal stem cell
EDAT- 2013/04/09 06:00
MHDA- 2013/04/09 06:01
CRDT- 2013/04/09 06:00
PHST- 2013/04/09 06:00 [entrez]
PHST- 2013/04/09 06:00 [pubmed]
PHST- 2013/04/09 06:01 [medline]
AID - 10.4103/2230-8210.104045 [doi]
AID - IJEM-16-227 [pii]
PST - ppublish
SO  - Indian J Endocrinol Metab. 2012 Dec;16(Suppl 2):S227-9. doi:
      10.4103/2230-8210.104045.


PMID- 23559953
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130408
LR  - 20211021
IS  - 1735-3327 (Print)
IS  - 1735-3327 (Linking)
VI  - 9
IP  - 6
DP  - 2012 Nov
TI  - Evaluation of orofacial lesions relating child abuse, Esfahan, Iran: A
      quantitative approach.
PG  - 748-51
AB  - BACKGROUND: Family violence, including child abuse, neglect, and domestic
      violence, is a public health problem. The aim of this study was to provide data
      on prevalence and factors of Orofacial lesions relating child abuse in Iran to
      lend evidence to support preventing child abuse. MATERIALS AND METHODS: The
      overall approach was a case-note review of children having child abuse note,
      recording by personnel of social services. Research ethical approval was sought
      from the Central social service organization. This study was conducted in
      Isfahan, Iran (2011). RESULT: The mean age of children, when abuse had been
      occurred was 8 years (SD = 1.68), and there were approximately an equal number of
      boys and girls. Children had a high physical experience (66.1%).Of these
      children, at least 60% sustained trauma to the face and mouth. Emotional abuse
      was 77.1%, neglect was 64.1%, and lower experience of sexual abuse which was
      4.1%. There was a strong relationship between gender and abuser which shows girls
      have been affected by stepfathers (P = 0.001). CONCLUSION: Preliminary data
      suggest that there are strong evidence regarding the incidence of child abuse
      relating orofacial lesions which dentists should be aware of them. Future trials 
      may draw on these useful baseline data to help their study design.
FAU - Nilchian, Firoozeh
AU  - Nilchian F
AD  - Torabinejad Dental Research Center and Department of Dental Public Health,
      Isfahan University of Medical Sciences, Isfahan, Iran.
FAU - Sadri, Leyli
AU  - Sadri L
FAU - Jabbarifar, Seyed Ebrahim
AU  - Jabbarifar SE
FAU - Saeidi, Alireza
AU  - Saeidi A
FAU - Arbab, Leila
AU  - Arbab L
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Dent Res J (Isfahan)
JT  - Dental research journal
JID - 101471186
PMC - PMC3612225
OTO - NOTNLM
OT  - Child abuse
OT  - Iran
OT  - child neglect
OT  - orofacial lesions
EDAT- 2013/04/06 06:00
MHDA- 2013/04/06 06:01
CRDT- 2013/04/06 06:00
PHST- 2013/04/06 06:00 [entrez]
PHST- 2013/04/06 06:00 [pubmed]
PHST- 2013/04/06 06:01 [medline]
PST - ppublish
SO  - Dent Res J (Isfahan). 2012 Nov;9(6):748-51.


PMID- 23559295
OWN - NLM
STAT- MEDLINE
DCOM- 20130930
LR  - 20131112
IS  - 0717-6163 (Electronic)
IS  - 0034-9887 (Linking)
VI  - 140
IP  - 10
DP  - 2012 Oct
TI  - [Informed consent in the patients' rights law].
PG  - 1347-51
LID - 10.4067/S0034-98872012001000017 [doi]
LID - S0034-98872012001000017 [pii]
AB  - BACKGROUND: The new regulation of patients' rights creates the right to informed 
      consent, which allows accepting or refusing any medical treatment. Also, the
      patient has the right to be appropriately informed about a variety of aspects
      determined by the law. Patient's autonomy has limits. Artificial acceleration of 
      death, euthanasia or assisted suicide are not permitted. The problem is that the 
      law does not define those situations. The law provides the intervention of Ethics
      Committees when the doctor considers that the patient exposes himself to severe
      harm or the risk of death which would be avoided. This intervention impinges on
      patient's autonomy. Patients have the right to request discharge and medical
      facilities could discharge patients against their will if they do not accept
      medical recommendations. These limitations on autonomy should be explained
      because the law apparently makes the distinction between killing, letting die and
      the Double Effect Doctrine. There is plenty of literature questioning the
      validity of both. The law fails to regulate part of the medical practice,
      regarding life and death decisions. A lack of consensus could explain this
      omission. Doctors have a right to conscientious objection to some patient's
      requests.
FAU - Figueroa G, Rodolfo
AU  - Figueroa G R
AD  - Facultad de Derecho, Universidad Diego Portales, Santiago, Chile.
      rodolfo.figueroa@udp.cl
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Consentimiento informado en la nueva ley de derechos de los pacientes.
PL  - Chile
TA  - Rev Med Chil
JT  - Revista medica de Chile
JID - 0404312
SB  - IM
MH  - Decision Making/ethics
MH  - Double Effect Principle
MH  - Euthanasia/ethics/legislation & jurisprudence
MH  - Humans
MH  - Informed Consent/ethics/*legislation & jurisprudence
MH  - Patient Rights/ethics/*legislation & jurisprudence
MH  - *Personal Autonomy
MH  - Physician's Role
MH  - Suicide, Assisted/ethics/legislation & jurisprudence
EDAT- 2013/04/06 06:00
MHDA- 2013/10/01 06:00
CRDT- 2013/04/06 06:00
PHST- 2012/04/02 00:00 [received]
PHST- 2012/06/04 00:00 [accepted]
PHST- 2013/04/06 06:00 [entrez]
PHST- 2013/04/06 06:00 [pubmed]
PHST- 2013/10/01 06:00 [medline]
AID - S0034-98872012001000017 [pii]
AID - 10.4067/S0034-98872012001000017 [doi]
PST - ppublish
SO  - Rev Med Chil. 2012 Oct;140(10):1347-51. doi: 10.4067/S0034-98872012001000017.


PMID- 23557469
OWN - NLM
STAT- MEDLINE
DCOM- 20140113
LR  - 20130405
IS  - 1756-5391 (Electronic)
IS  - 1756-5391 (Linking)
VI  - 5
IP  - 2
DP  - 2012 May
TI  - Subject, function, and trend in medical ethics research: a comparative study of
      Chinese and non-Chinese literature using bibliometrics.
PG  - 57-65
LID - 10.1111/j.1756-5391.2012.01178.x [doi]
AB  - OBJECTIVE: To perform a comparative quantitative and qualitative analysis of
      Chinese and non-Chinese medical ethics literature using systematic research and
      literature analysis in order to discern research trends in the area and provide
      baseline data as a reference for relevant decision making and further study.
      METHOD: We retrieved articles using MeSH terms and keywords related to medical
      ethics in PubMed and CNKI, and then constructed a set of charts by applying word 
      co-occurrence, The Pathfinder Networks algorithms, an included subject chart, a
      research field relationship chart, and strategy coordination charts. RESULT: The 
      total of number of papers retrieved from PubMed was six times that retrieved from
      CNKI. Outside China, medical ethics has been studied in eight fully shaped
      subject fields, including morals, ethical review, physician-patient
      relationships, clinical trials, euthanasia, ethics education, clinical ethics,
      and health policy. In contrast, medical ethics research in China is still
      confined to five subject fields: morals, physician-patient relations, medical
      ethics education, ethical review, and medical research. CONCLUSION: Medical
      ethics research outside China emphasizes the application of medical ethics to
      solve emerging problems in clinical and medical research. It is mainly centered
      on morals, ethical review, and physician-patient relations. By comparison,
      medical ethics research in China places greater emphasis on morals and medical
      education. In order to narrow this gap between China and other countries, we
      should broaden the research scope of medical ethics and add more applied
      research, such as ethical review and medical education.
CI  - (c) 2012 Blackwell Publishing Asia Pty Ltd and Chinese Cochrane Center, West
      China Hospital of Sichuan University.
FAU - Jiang, Lanhui
AU  - Jiang L
AD  - Chinese Evidence-Based Medicine Center, Sichuan University, Chengdu, China.
FAU - Shen, Jiantong
AU  - Shen J
FAU - Li, Youping
AU  - Li Y
FAU - Deng, Shaolin
AU  - Deng S
FAU - Wu, Taixiang
AU  - Wu T
FAU - Chen, Baoqing
AU  - Chen B
FAU - Xie, Zhiyi
AU  - Xie Z
FAU - Qin, Chaoyi
AU  - Qin C
FAU - Yu, Zhiyuan
AU  - Yu Z
FAU - Qin, Chuan
AU  - Qin C
FAU - Huang, Jin
AU  - Huang J
FAU - Liu, Xuemei
AU  - Liu X
FAU - Li, Yan
AU  - Li Y
FAU - Jiang, Jie
AU  - Jiang J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - J Evid Based Med
JT  - Journal of evidence-based medicine
JID - 101497477
SB  - IM
MH  - *Bibliometrics
MH  - China
MH  - Cluster Analysis
MH  - *Ethics, Medical
MH  - Research/trends
EDAT- 2013/04/06 06:00
MHDA- 2014/01/15 06:00
CRDT- 2013/04/06 06:00
PHST- 2013/04/06 06:00 [entrez]
PHST- 2013/04/06 06:00 [pubmed]
PHST- 2014/01/15 06:00 [medline]
AID - 10.1111/j.1756-5391.2012.01178.x [doi]
PST - ppublish
SO  - J Evid Based Med. 2012 May;5(2):57-65. doi: 10.1111/j.1756-5391.2012.01178.x.


PMID- 23551770
OWN - NLM
STAT- MEDLINE
DCOM- 20131125
LR  - 20220409
IS  - 1754-9485 (Electronic)
IS  - 1754-9477 (Linking)
VI  - 57
IP  - 2
DP  - 2013 Apr
TI  - Dynamic volumetric computed tomographic assessment of the young paediatric
      airway: Initial experience of rapid, non-invasive, four-dimensional technique.
PG  - 141-8
LID - 10.1111/1754-9485.12009 [doi]
AB  - INTRODUCTION: The aim of this study was to evaluate the dynamic volumetric CT in 
      the assessment of the paediatric airway. METHODS: Ethics board approval was
      obtained for this retrospective review. Eight infants (median age 6 months, range
      3 weeks to 1 year, 50% female) at a tertiary paediatric centre with complex
      clinical respiratory presentation underwent volumetric CT assessment of their
      airways. The entire lungs were examined over 1-2 respiratory cycles. In four
      patients, intravenous contrast was administered to assess for vascular airway
      compression. The patients were not intubated. CT findings were correlated with
      bronchography and bronchoscopy, where available. RESULTS: Two patients had
      diffuse tracheobronchomalacia associated with chronic lung disease. One patient
      demonstrated focal severe cervical tracheomalacia. One patient had a double
      aortic arch causing fixed narrowing with superimposed malacia of the distal
      trachea. Four patients had normal airways; one with chronic lung disease, one
      demonstrating air trapping. CT findings were concordant with bronchography (one
      case) and bronchoscopy (four cases) in all but one (CT negative, bronchoscopy
      positive) but did not alter patient management. CONCLUSION: The assessment of the
      paediatric airway, and in particular for tracheobronchomalacia, is difficult.
      Assessment with bronchography, bronchoscopy, helical CT and MR have issues with
      reliability, intubation, intratracheal/bronchial contrast administration and
      ionising radiation. Volumetric CT assesses the entire central airway in children 
      at much lower radiation dose compared with previous dynamic CT imaging. This
      non-invasive, rapid assessment obviates the need for patient cooperation and
      enables evaluation of extratracheal intrathoracic structures. Volumetric CT
      enables four-dimensional assessment for paediatric tracheobronchomalacia without 
      intubation or patient cooperation and at low radiation dose.
CI  - (c) 2012 The Authors. Journal of Medical Imaging and Radiation Oncology (c) 2012 
      The Royal Australian and New Zealand College of Radiologists.
FAU - Tan, Judith Zhi-Yie
AU  - Tan JZ
AD  - Department of Diagnostic Imaging, Monash Children's, Southern Health, Melbourne, 
      Victoria, Australia. zhi_yie@yahoo.com.au
FAU - Crossett, Marcus
AU  - Crossett M
FAU - Ditchfield, Michael
AU  - Ditchfield M
LA  - eng
PT  - Journal Article
DEP - 20121228
PL  - Australia
TA  - J Med Imaging Radiat Oncol
JT  - Journal of medical imaging and radiation oncology
JID - 101469340
RN  - 0 (Contrast Media)
RN  - 4419T9MX03 (Iohexol)
SB  - IM
MH  - Contrast Media
MH  - Female
MH  - Four-Dimensional Computed Tomography/*methods
MH  - Humans
MH  - Infant
MH  - *Iohexol
MH  - Male
MH  - Pilot Projects
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Trachea/*diagnostic imaging
MH  - Tracheobronchomalacia/*diagnostic imaging
EDAT- 2013/04/05 06:00
MHDA- 2013/12/16 06:00
CRDT- 2013/04/05 06:00
PHST- 2012/04/23 00:00 [received]
PHST- 2012/07/24 00:00 [accepted]
PHST- 2013/04/05 06:00 [entrez]
PHST- 2013/04/05 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1111/1754-9485.12009 [doi]
PST - ppublish
SO  - J Med Imaging Radiat Oncol. 2013 Apr;57(2):141-8. doi: 10.1111/1754-9485.12009.
      Epub 2012 Dec 28.


PMID- 23550438
OWN - NLM
STAT- MEDLINE
DCOM- 20130626
LR  - 20161125
IS  - 1462-4753 (Print)
IS  - 1462-4753 (Linking)
VI  - 17
IP  - 12
DP  - 2012 Dec
TI  - Smoking cessation: promoting the health of older people who smoke.
PG  - 606, 608-11
AB  - Community nurses are well placed to address smoking behaviour with older people. 
      Smoking cessation can significantly improve the health and wellbeing of older
      people, and to withhold support for smoking cessation is a form of age
      discrimination. This paper provides advice to community nurses about how to
      approach discussions about smoking behaviour with older clients as part of their 
      health education practice. It addresses some of the ethical concerns that have
      been raised by community nurses, explains how smoking in older people may be
      reduced using a harm reduction apporoach and through working with the concept of 
      the smoke-free home.
FAU - Phillips, Adele
AU  - Phillips A
AD  - Department of Health, Wellbeing and Family/Department of Nursing and Applied
      Clinical Studies, Faculty of Health and Social Care, Canterbury Christ Church
      University. adele.phillips@canterbury.ac.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Community Nurs
JT  - British journal of community nursing
JID - 9815827
RN  - 0 (Tobacco Smoke Pollution)
MH  - Aged
MH  - *Community Health Nursing/ethics
MH  - *Harm Reduction
MH  - *Health Promotion
MH  - Humans
MH  - Middle Aged
MH  - Practice Guidelines as Topic
MH  - Smoke-Free Policy
MH  - *Smoking Cessation
MH  - Tobacco Smoke Pollution/prevention & control
MH  - United Kingdom
EDAT- 2013/04/05 06:00
MHDA- 2013/06/28 06:00
CRDT- 2013/04/05 06:00
PHST- 2013/04/05 06:00 [entrez]
PHST- 2013/04/05 06:00 [pubmed]
PHST- 2013/06/28 06:00 [medline]
AID - 10.12968/bjcn.2012.17.12.606 [doi]
PST - ppublish
SO  - Br J Community Nurs. 2012 Dec;17(12):606, 608-11. doi:
      10.12968/bjcn.2012.17.12.606.


PMID- 23549749
OWN - NLM
STAT- MEDLINE
DCOM- 20140127
LR  - 20130521
IS  - 1552-7468 (Electronic)
IS  - 1527-1544 (Linking)
VI  - 13
IP  - 4
DP  - 2012 Nov
TI  - Legislation affecting governmental assistance for children of parents with
      substance use: a policy analysis of social justice.
PG  - 195-204
LID - 10.1177/1527154413481678 [doi]
AB  - There is legislation that withdraws governmental assistance where parents are
      using drugs. Social justice is an important consideration in any policy that
      modifies governmental assistance that benefits vulnerable children. The purpose
      of this policy analysis is to analyze identified legislation that effect
      governmental assistance for children in response to parents' substance misuse. A 
      selective review of data-driven studies examined findings describing actual or
      potential effects on children of legislation targeting parental substance misuse.
      Challenges in design, processes, and implementation contribute to poor child
      outcomes. Identifiable constructs of social justice were missing in the reviewed 
      legislation. Social injustice is a potential outcome for children when
      legislative intent focuses solely on addressing parental drug behaviors.
      Legislative alternatives to withdrawing support can address substance abuse while
      maintaining health promotion for these vulnerable children.
FAU - Raynor, Phyllis
AU  - Raynor P
AD  - Medical University of South Carolina, Irmo, SC 29063, USA. raynorp@musc.edu
FAU - Williams, Pamela Holtzclaw
AU  - Williams PH
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20130402
PL  - United States
TA  - Policy Polit Nurs Pract
JT  - Policy, politics & nursing practice
JID - 100901316
SB  - IM
MH  - Child
MH  - Child of Impaired Parents/*legislation & jurisprudence
MH  - Child, Preschool
MH  - Health Policy/*legislation & jurisprudence
MH  - Health Services Accessibility/*legislation & jurisprudence
MH  - Humans
MH  - Medical Assistance/ethics/*legislation & jurisprudence
MH  - Parents
MH  - Politics
MH  - Social Justice/*legislation & jurisprudence
MH  - *Substance-Related Disorders
MH  - United States
MH  - Vulnerable Populations/legislation & jurisprudence
OTO - NOTNLM
OT  - children's health
OT  - coverage/access
OT  - ethical issues
OT  - federal legislation
OT  - political action
OT  - public health
EDAT- 2013/04/04 06:00
MHDA- 2014/01/28 06:00
CRDT- 2013/04/04 06:00
PHST- 2013/04/04 06:00 [entrez]
PHST- 2013/04/04 06:00 [pubmed]
PHST- 2014/01/28 06:00 [medline]
AID - 1527154413481678 [pii]
AID - 10.1177/1527154413481678 [doi]
PST - ppublish
SO  - Policy Polit Nurs Pract. 2012 Nov;13(4):195-204. doi: 10.1177/1527154413481678.
      Epub 2013 Apr 2.


PMID- 23543923
OWN - NLM
STAT- MEDLINE
DCOM- 20130515
LR  - 20211021
IS  - 0008-5286 (Print)
IS  - 0008-5286 (Linking)
VI  - 53
IP  - 10
DP  - 2012 Oct
TI  - An ethicist's commentary on the pharmaceutical supply house.
PG  - 1034
FAU - Rollin, Bernard E
AU  - Rollin BE
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Vet J
JT  - The Canadian veterinary journal = La revue veterinaire canadienne
JID - 0004653
RN  - 0 (Prescription Drugs)
RN  - 0 (Veterinary Drugs)
SB  - IM
MH  - Animals
MH  - Canada
MH  - Commerce/economics/ethics
MH  - *Ethics, Professional
MH  - Humans
MH  - Income
MH  - Prescription Drugs
MH  - Veterinarians/*economics/*ethics/psychology
MH  - Veterinary Drugs/*economics/supply & distribution
MH  - Veterinary Medicine/*ethics
PMC - PMC3447306
EDAT- 2013/04/02 06:00
MHDA- 2013/05/17 06:00
CRDT- 2013/04/02 06:00
PHST- 2013/04/02 06:00 [entrez]
PHST- 2013/04/02 06:00 [pubmed]
PHST- 2013/05/17 06:00 [medline]
PST - ppublish
SO  - Can Vet J. 2012 Oct;53(10):1034.


PMID- 23543817
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130402
LR  - 20211021
IS  - 2193-6331 (Print)
IS  - 2193-634X (Linking)
VI  - 73
IP  - 2
DP  - 2012 Apr
TI  - Clinicopathologic assay of 15 tumor resections in a family with neurofibromatosis
      type 2.
PG  - 90-103
LID - 10.1055/s-0032-1301394 [doi]
AB  - The objective of this study is the management of multiple family members with
      multiple neurofibromatosis type 2 (NF2) related tumors of the skull base that can
      be challenging, on purely technical, decision-making, and ethical levels. These
      issues are addressed in this manuscript based on an experience treating an unique
      large family with NF2. A retrospective chart review was performed, reviewing
      clinical, radiological, surgical, and pathological data. A unique family of 17
      siblings, whose father was the proband as a sporadic mutation is reported. Over a
      4-month period, five of eight affected siblings underwent 12 procedures for
      resection of 15 different NF2-related tumors. This single family experience of
      NF2-related skull base tumors underscores the importance of preservation of
      function and quality of life as the major determinants of treatment success.
FAU - Di Maio, Salvatore
AU  - Di Maio S
AD  - Department of Neurological Surgery, University of Washington, Harborview Medical 
      Center, Seattle, Washington.
FAU - Mrak, Goran
AU  - Mrak G
FAU - Juric-Sekhar, Gordana
AU  - Juric-Sekhar G
FAU - Born, Donald
AU  - Born D
FAU - Mantovani, Alessandra
AU  - Mantovani A
FAU - Sekhar, Laligam N
AU  - Sekhar LN
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - J Neurol Surg B Skull Base
JT  - Journal of neurological surgery. Part B, Skull base
JID - 101580780
PMC - PMC3424622
OTO - NOTNLM
OT  - NF2 associated tumors
OT  - ethics
OT  - meningioma
OT  - neurofibromatosis type 2
OT  - quality of life
OT  - vestibular schwannoma
EDAT- 2013/04/02 06:00
MHDA- 2013/04/02 06:01
CRDT- 2013/04/02 06:00
PHST- 2011/06/06 00:00 [received]
PHST- 2011/10/18 00:00 [accepted]
PHST- 2013/04/02 06:00 [entrez]
PHST- 2013/04/02 06:00 [pubmed]
PHST- 2013/04/02 06:01 [medline]
AID - 10.1055/s-0032-1301394 [doi]
AID - 73090 [pii]
PST - ppublish
SO  - J Neurol Surg B Skull Base. 2012 Apr;73(2):90-103. doi: 10.1055/s-0032-1301394.


PMID- 23543246
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130402
LR  - 20211021
IS  - 2249-782X (Print)
IS  - 0973-709X (Linking)
VI  - 7
IP  - 2
DP  - 2013 Feb
TI  - A Clinico-Pathological Study of Lichenoid Tissue Reactions-A Tertiary Care
      experience.
PG  - 312-6
LID - 10.7860/JCDR/2013/5110.2755 [doi]
AB  - INTRODUCTION: The aim of this article was to study the spectrum of
      clinico-histopathological lesions with an age and sex distribution in various
      lichenoid reactions of the skin. The spectrum of clinical diseases which is
      related to the lichenoid tissue reaction is wider. There is a recent increase in 
      the relatively new subgroups of the lichenoid clinical picture. MATERIAL AND
      METHODS: This was a one and a half year prospective study which was conducted in 
      the Dermatopathology Section of the Department of Pathology, from January 2011 to
      June 2012. All the patients who visited the Dermatology Outpatients/ Inpatients
      Department and presented with lichenoid tissue reactions were included in the
      study. The selected patients' clinical findings were noted and their informed
      consents and an institutional ethical clearance were taken. Light microscopy was 
      used for the histopathological diagnosis. The SPSS, version 14 software was used 
      to analyze the data. Frequencies and percentages were used to describe the data. 
      RESULTS: During the study period, 107 cases were clinically diagnosed as
      lichenoid reactions, of which 84 cases were concordant on histopathology and 6
      cases were diagnosed, solely based on the histology. So, a total of 90 cases were
      diagnosed histologically, of which 42 were of the Lichen planus type and 48 were 
      lichenoid eruptions. Females were affected more commonly than the males.
      CONCLUSION: In our study, the lichenoid reactions were more common in children
      and the most common prototype was Lichen planus. So, we conclude that
      histopathology is a dependable tool for identifying the underlying cause in
      lichenoid reactions.
FAU - Kumar U, Mahesh
AU  - Kumar U M
AD  - Assistant Professor, Department of Dermatopathology.
FAU - Yelikar, Balasaheb Ramling
AU  - Yelikar BR
FAU - Inamadar, Arun C
AU  - Inamadar AC
FAU - Umesh, Swaroopa
AU  - Umesh S
FAU - Singhal, Amrita
AU  - Singhal A
FAU - Kushtagi, Anirudha V
AU  - Kushtagi AV
LA  - eng
PT  - Journal Article
DEP - 20121129
PL  - India
TA  - J Clin Diagn Res
JT  - Journal of clinical and diagnostic research : JCDR
JID - 101488993
PMC - PMC3592300
OTO - NOTNLM
OT  - Histopathology
OT  - Lichen eruption
OT  - Lichen planus
OT  - Lichenoid tissue reaction
EDAT- 2013/04/02 06:00
MHDA- 2013/04/02 06:01
CRDT- 2013/04/02 06:00
PHST- 2012/09/22 00:00 [received]
PHST- 2012/11/14 00:00 [accepted]
PHST- 2013/04/02 06:00 [entrez]
PHST- 2013/04/02 06:00 [pubmed]
PHST- 2013/04/02 06:01 [medline]
AID - 10.7860/JCDR/2013/5110.2755 [doi]
PST - ppublish
SO  - J Clin Diagn Res. 2013 Feb;7(2):312-6. doi: 10.7860/JCDR/2013/5110.2755. Epub
      2012 Nov 29.


PMID- 23543065
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130402
LR  - 20211021
IS  - 1205-7088 (Print)
IS  - 1205-7088 (Linking)
VI  - 17
IP  - 4
DP  - 2012 Apr
TI  - Paediatric research and the communication of not-so incidental findings.
PG  - 190-2
AB  - Paediatric research may well be the first field in which the ethical implications
      of next-generation sequencing (NGS) will be appreciated. Allowing as it does for 
      the revelation of much more than just the disease gene being researched, the
      advent of NGS will require careful consideration of the return of research
      results and incidental findings to parents. In contrast to the choices offered to
      adults with regard to the return of both research results and incidental
      findings, the same does not hold true for children. Parents must act in their
      'medical' best interests. Current policy guidance on this issue in Canada is
      unclear.
FAU - Knoppers, Bartha Maria
AU  - Knoppers BM
AD  - Centre of Genomics and Policy, Faculty of Medicine (Department of Human
      Genetics), McGill University, Montreal, Quebec.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Paediatr Child Health
JT  - Paediatrics & child health
JID - 9815960
PMC - PMC3381660
OTO - NOTNLM
OT  - Ethics
OT  - Incidental findings
OT  - Next-generation sequencing
OT  - Paediatrics
OT  - Research results
EDAT- 2013/04/02 06:00
MHDA- 2013/04/02 06:01
CRDT- 2013/04/02 06:00
PHST- 2011/10/01 00:00 [accepted]
PHST- 2013/04/02 06:00 [entrez]
PHST- 2013/04/02 06:00 [pubmed]
PHST- 2013/04/02 06:01 [medline]
AID - 10.1093/pch/17.4.190 [doi]
PST - ppublish
SO  - Paediatr Child Health. 2012 Apr;17(4):190-2. doi: 10.1093/pch/17.4.190.


PMID- 23542570
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130402
LR  - 20211021
IS  - 2249-782X (Print)
IS  - 0973-709X (Linking)
VI  - 7
IP  - 2
DP  - 2013 Feb
TI  - Serum carbohydrate deficient transferrin as a sensitive marker in diagnosing
      alcohol abuse: a case - control study.
PG  - 197-200
LID - 10.7860/JCDR/2013/5137.2726 [doi]
AB  - BACKGROUND: Alcoholism is a major problem in India thereby causing a heavy toll
      on the health related expenditure of the country. Detection of alcohol abuse rely
      mainly on clinical details which is sometimes inaccurate or unreliable and hence 
      using a specific diagnostic parameter might be of immense use not only for early 
      diagnosis but also during follow up of the cases. AIMS AND OBJECTIVES: This case 
      control study aimed at evaluating the usefulness of Carbohydrate Deficient
      Transferrin (CDT) as a sensitive marker to diagnose alcohol abuse. MATERIALS AND 
      METHODS: The study was approved by Institutional research and ethical committee. 
      Twenty five known male alcoholics who attended to the OPD (Out Patient
      Department) of Alcohol de-addiction centre of a tertiary care hospital were
      selected as cases. All of them were diagnosed to have a strong likely hood of
      hazardous alcohol consumption based on 'Alcohol Use Disorders Identification
      Test" (AUDIT) questionnaire. Twenty five age matched, gender matched healthy
      individuals who were teetotalers were selected as controls. They scored zero in
      AUDIT questionnaire. Informed consent was obtained from all the cases and
      controls. The following tests were done: Liver function tests including Serum
      Bilirubin, Total Proteins, Aspartate Amino Transferase (AST), Alanine Amino
      Transferase (ALT), Alkaline Phosphatase (ALP), Gamma Glutamyl Transferase (GGT)
      and Blood glucose levels were estimated using a fully automated biochemistry
      analyser, XL - 300 (Trans Asia Biomedical systems) and Mean Corpuscular Volume
      (MCV) was done using an automated hematology analyser Sysmex KX-21. Percentage of
      Serum Carbohydrate Deficient Transferrin (%CDT) was assessed using immuno
      Turbidimetric assay, ELISA method (iMark, Bio-Rad Laboratories,). Statistical
      analysis of the data obtained was done using SPSS 16.0. RESULTS: There was a
      statistically significant difference in values of AST, ALT, ALP, MCV, GGT and %
      CDT in cases as compared to controls. ROC curves drawn to assess the sensitivity 
      and specificity of each parameter showed that %CDT has the highest sensitivity
      and specificity (84% and 92% respectively) and MCV (48% and 52% respectively) had
      the least. GGT when compared to % CDT had a lower sensitivity and specificity
      (64% and 72% respectively). CONCLUSION: % CDT is a sensitive biomarker which can 
      be used to diagnose alcohol abuse and is superior to GGT in terms of sensitivity 
      as well as specificity.
FAU - Madhubala, V
AU  - Madhubala V
AD  - Associate Professor of Biochemistry, ESI hospital & PGIMSR , K K Nagar, Chennai, 
      India .
FAU - Subhashree, A R
AU  - Subhashree AR
FAU - Shanthi, B
AU  - Shanthi B
LA  - eng
PT  - Journal Article
DEP - 20121224
PL  - India
TA  - J Clin Diagn Res
JT  - Journal of clinical and diagnostic research : JCDR
JID - 101488993
PMC - PMC3592273
OTO - NOTNLM
OT  - % CDT
OT  - Alcohol abuse
OT  - Diagnostic marker
OT  - GGT,
EDAT- 2013/04/02 06:00
MHDA- 2013/04/02 06:01
CRDT- 2013/04/02 06:00
PHST- 2012/10/01 00:00 [received]
PHST- 2012/11/14 00:00 [accepted]
PHST- 2013/04/02 06:00 [entrez]
PHST- 2013/04/02 06:00 [pubmed]
PHST- 2013/04/02 06:01 [medline]
AID - 10.7860/JCDR/2013/5137.2726 [doi]
PST - ppublish
SO  - J Clin Diagn Res. 2013 Feb;7(2):197-200. doi: 10.7860/JCDR/2013/5137.2726. Epub
      2012 Dec 24.


PMID- 23540515
OWN - NLM
STAT- MEDLINE
DCOM- 20131223
LR  - 20130401
IS  - 1532-8228 (Electronic)
IS  - 0883-9417 (Linking)
VI  - 27
IP  - 2
DP  - 2013 Apr
TI  - Addressing methodological and ethical challenges of qualitative health research
      on persons with schizophrenia and bipolar disorder.
PG  - 65-71
LID - 10.1016/j.apnu.2012.10.006 [doi]
LID - S0883-9417(12)00150-1 [pii]
AB  - Qualitative studies of persons with schizophrenia and bipolar disorder may affect
      clinical practice and social policy. However, methodological and ethical
      challenges may present during studies of persons with these specific mental
      illnesses. The purpose of this paper is to increase transparency about how
      researchers addressed these challenges during a recent grounded theory study
      about engagement in primary care. As the researchers addressed the challenges,
      they increased understanding about persons with schizophrenia and bipolar
      disorder. They also gained insight about the challenges of studying persons with 
      these specific mental illnesses and about the rigor and credibility of
      qualitative methods.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Graor, Christine Heifner
AU  - Graor CH
AD  - School of Nursing, The University of Akron, OH, USA. graor@uakron.edu
FAU - Knapik, Gregory P
AU  - Knapik GP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121221
PL  - United States
TA  - Arch Psychiatr Nurs
JT  - Archives of psychiatric nursing
JID - 8708534
SB  - IM
MH  - Bipolar Disorder/*therapy
MH  - Data Collection
MH  - Data Interpretation, Statistical
MH  - *Ethics, Research
MH  - Humans
MH  - Informed Consent/ethics
MH  - Patient Selection/ethics
MH  - *Qualitative Research
MH  - Schizophrenia/*therapy
EDAT- 2013/04/02 06:00
MHDA- 2013/12/24 06:00
CRDT- 2013/04/02 06:00
PHST- 2012/07/28 00:00 [received]
PHST- 2012/10/26 00:00 [revised]
PHST- 2012/10/31 00:00 [accepted]
PHST- 2013/04/02 06:00 [entrez]
PHST- 2013/04/02 06:00 [pubmed]
PHST- 2013/12/24 06:00 [medline]
AID - S0883-9417(12)00150-1 [pii]
AID - 10.1016/j.apnu.2012.10.006 [doi]
PST - ppublish
SO  - Arch Psychiatr Nurs. 2013 Apr;27(2):65-71. doi: 10.1016/j.apnu.2012.10.006. Epub 
      2012 Dec 21.


PMID- 23539831
OWN - NLM
STAT- MEDLINE
DCOM- 20130508
LR  - 20211021
IS  - 1565-4753 (Print)
IS  - 1565-4753 (Linking)
VI  - 10
IP  - 2
DP  - 2012 Dec-2013 Jan
TI  - The role of electronic assessment of adherence in the education and counseling of
      children taking growth hormone: progress and challenges.
PG  - 199-208
AB  - There are numerous issues surrounding adherence in children taking recombinant
      human growth hormone (rh-GH). New technologies capable of accurately
      recording/monitoring may highlight some of these issues, and have value in
      optimizing adherence levels through education and counseling. The intention of
      this review is to guide healthcare professionals (HCPs). PubMed, Google Scholar
      and citations in published papers were used to substantiate the views expressed
      by the authors. Both perceptional and practical factors influence the adherence
      levels of children taking rh-GH. Understanding such factors may help to identify 
      the characteristics of ideal rh-GH devices and their potential impact on
      adherence. New technologies, such as electronic monitors, may facilitate
      patient-provider discussions on adherence, and help identify barriers that are
      amenable to change. Monitoring adherence may also help differentiate nonadherence
      from biological low response to rh-GH therapy. However, the medical,
      psychological, social and ethical aspects of electronic assessment require
      further investigation.
FAU - Haverkamp, Fritz
AU  - Haverkamp F
AD  - University of Applied Science, Bochum, Germany. f.haverkamp@efh-bochum.de
FAU - Norgren, Svante
AU  - Norgren S
FAU - Horne, Rob
AU  - Horne R
FAU - Gasteyger, Christoph
AU  - Gasteyger C
LA  - eng
GR  - NF-SI-0510-10197/DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Israel
TA  - Pediatr Endocrinol Rev
JT  - Pediatric endocrinology reviews : PER
JID - 101202124
RN  - 12629-01-5 (Human Growth Hormone)
SB  - IM
MH  - Child
MH  - Counseling/methods
MH  - Drug Monitoring/instrumentation/*methods
MH  - Electronics, Medical
MH  - Human Growth Hormone/*administration & dosage
MH  - Humans
MH  - Injections/instrumentation
MH  - Medication Adherence/psychology/*statistics & numerical data
MH  - *Patient Education as Topic
EDAT- 2013/04/02 06:00
MHDA- 2013/05/09 06:00
CRDT- 2013/04/02 06:00
PHST- 2013/04/02 06:00 [entrez]
PHST- 2013/04/02 06:00 [pubmed]
PHST- 2013/05/09 06:00 [medline]
PST - ppublish
SO  - Pediatr Endocrinol Rev. 2012 Dec-2013 Jan;10(2):199-208.


PMID- 28839716
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 2041-4137 (Print)
IS  - 2041-4137 (Linking)
VI  - 4
IP  - 2
DP  - 2013 Apr
TI  - How to teach reflective ethical practice in postgraduate gastroenterology: the
      SLICE framework.
PG  - 143-146
LID - 10.1136/flgastro-2012-100249 [doi]
AB  - Professionalism and performance are now the focus of assessment in postgraduate
      medical training and revalidation in the UK. Ethical decision making and clinical
      reasoning are key elements for practising gastroenterologists to master. The
      skills required to reflect, teach and appraise ethical decision making are
      central to the effectiveness of relationships with patients and colleagues. A
      framework is presented to enable gastroenterologists to reflect and learn from
      everyday ethical dilemmas in clinical practice.
FAU - Webster, Shelby
AU  - Webster S
LA  - eng
PT  - Journal Article
DEP - 20121214
PL  - England
TA  - Frontline Gastroenterol
JT  - Frontline gastroenterology
JID - 101528589
PMC - PMC5369809
OTO - NOTNLM
OT  - Artificial Nutrition Support
OT  - Endoscopic Gastrostomy
OT  - Endoscopy
OT  - Nutritional Support
OT  - Psychology
EDAT- 2013/04/01 00:00
MHDA- 2013/04/01 00:01
CRDT- 2017/08/26 06:00
PHST- 2012/08/07 00:00 [received]
PHST- 2012/11/11 00:00 [revised]
PHST- 2012/11/12 00:00 [accepted]
PHST- 2017/08/26 06:00 [entrez]
PHST- 2013/04/01 00:00 [pubmed]
PHST- 2013/04/01 00:01 [medline]
AID - 10.1136/flgastro-2012-100249 [doi]
AID - flgastro-2012-100249 [pii]
PST - ppublish
SO  - Frontline Gastroenterol. 2013 Apr;4(2):143-146. doi:
      10.1136/flgastro-2012-100249. Epub 2012 Dec 14.


PMID- 23520920
OWN - NLM
STAT- MEDLINE
DCOM- 20130429
LR  - 20161021
IS  - 1134-7198 (Print)
IS  - 1134-7198 (Linking)
IP  - 37
DP  - 2012 Jul-Dec
TI  - To be or not IP? Exploring limits within patent law for the constitutionalization
      of intellectual property rights and the governance of synthetic biology in human 
      health.
PG  - 193-233
AB  - The article explores limits within patent law for the constitutionalization of
      Intellectual Property Rights and the governance of synthetic biology in human
      health. To this end, it starts by explaining the inherent rationales of two
      fundamental limits within European patent law, namely (1) the boundary between
      discovery and invention (Art. 52 EPC); (2) the ordre public and public policy
      clause (Art. 53 (a) EPC). Both these exclusions from patent eligibility bear a
      normative function but rely on opposing inherent logics, functions, and
      regulatory aims. While in the first type of logics, "enabling access for all" is 
      the guiding principle, in the second, converse logics, no one should have access 
      to the technological knowledge in question. The second part contends that
      decisions on whether and how to grant patents in synthetic biology are not
      independent from institutional frameworks: The arena in which synthetic biology
      patenting will be dealt with will be decisive for whether and how boundaries will
      be deployed. From a political science perspective, the administrative,
      legislative and judicial arena can be distinguished. If synthetic biology will be
      negotiated in the legislative arena, in particular in the European Parliament,
      the probabilities will be higher that either the discovery clause or the ordre
      public clause will be applied. In contrast, patent offices and courts have, at
      least in the past decades, employed a narrow interpretation of these absolute
      exemptions from patentability and hardly ever used them. The third part asserts
      that metaphoric framing of synthetic biology is another crucial factor for
      patentability questions. Semantic framing may relate to the articulation and
      mobilization of consent or dissent, and thus public acceptance of synthetic
      biology. Whether applications of synthetic biology are conceived as "natural" or 
      "synthetic" DNA may have an influence on whether patenting might become contested
      as "patenting life" or accepted as novel, and also on passing the inventive step 
      and industrial application tests. Proceeding in such a manner can be regarded as 
      "upstreaming" ethics, anticipatory impact assessment, and policy analysis in the 
      biosciences and as a tool for constitutionalizing intellectual property rights.
FAU - Schneider, Ingrid
AU  - Schneider I
AD  - FSP BIOGUM, Centre for Biotechnology, Society and the Environment-Medicine.
      Ingrid.Schneider@uni-hamburg.de
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Spain
TA  - Rev Derecho Genoma Hum
JT  - Revista de derecho y genoma humano = Law and the human genome review
JID - 101558644
SB  - IM
MH  - Humans
MH  - *Intellectual Property
MH  - Ownership/*legislation & jurisprudence
MH  - Patents as Topic/*legislation & jurisprudence
MH  - Synthetic Biology/*legislation & jurisprudence
EDAT- 2013/03/26 06:00
MHDA- 2013/04/30 06:00
CRDT- 2013/03/26 06:00
PHST- 2013/03/26 06:00 [entrez]
PHST- 2013/03/26 06:00 [pubmed]
PHST- 2013/04/30 06:00 [medline]
PST - ppublish
SO  - Rev Derecho Genoma Hum. 2012 Jul-Dec;(37):193-233.


PMID- 23520917
OWN - NLM
STAT- MEDLINE
DCOM- 20130429
LR  - 20161021
IS  - 1134-7198 (Print)
IS  - 1134-7198 (Linking)
IP  - 37
DP  - 2012 Jul-Dec
TI  - [Genetic individuality and the universal declaration on the human genome and
      human rights].
PG  - 123-51
AB  - In this article we explore the epistemic and ontological relationship between
      science and law through the concept of individual in the Universal Declaration of
      the Human Genome and Human Rights. We argue for a better understanding of this
      relationship in order to foresee ethical and social consequences derived from Law
      adopting concepts with a strong scientific meaning.
FAU - Siqueiros, Jesus M
AU  - Siqueiros JM
AD  - Departamento de Estudios Juridicos, Eticos y Sociales, Instituto Nacional de
      Medicina Genomica, Mexico, DF Mexico. jmsiqueiros.bioetica@gmail.com
FAU - Saruwatari, Garbine
AU  - Saruwatari G
FAU - Oliva-Sanchez, Pablo Francisco
AU  - Oliva-Sanchez PF
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Individualidad genetica y la declara- cion universal sobre el genoma hu- mano y
      los derechos humanos.
PL  - Spain
TA  - Rev Derecho Genoma Hum
JT  - Revista de derecho y genoma humano = Law and the human genome review
JID - 101558644
SB  - IM
MH  - *Codes of Ethics
MH  - *Genetics, Medical
MH  - *Genome, Human
MH  - *Human Rights
MH  - Humans
MH  - *Individuality
EDAT- 2013/03/26 06:00
MHDA- 2013/04/30 06:00
CRDT- 2013/03/26 06:00
PHST- 2013/03/26 06:00 [entrez]
PHST- 2013/03/26 06:00 [pubmed]
PHST- 2013/04/30 06:00 [medline]
PST - ppublish
SO  - Rev Derecho Genoma Hum. 2012 Jul-Dec;(37):123-51.


PMID- 23520915
OWN - NLM
STAT- MEDLINE
DCOM- 20130429
LR  - 20161021
IS  - 1134-7198 (Print)
IS  - 1134-7198 (Linking)
IP  - 37
DP  - 2012 Jul-Dec
TI  - [Meta-legal paradigms of nanomedicine].
PG  - 61-91
AB  - Nanomedicine is the Nanotechnology applied in the field of Medicine. Nanomedicine
      includes a wide range of technologies applied to devices, materials, medical
      procedures and treatment modalities are being developed, in some cases, through
      the convergence of living and nonliving materials. The developments in this
      scientific field are the prelude of a new era in health where Nanotechnology will
      provide, in a short period of time, substantial benefits for the general welfare 
      and health of people with serious and incurable diseases using other more
      traditional medical treatments. This is, in brief, the object of this research
      that has been focused in the study of the ethical-legal paradigms that should
      inform the developments and expectations generated by medical applications of
      Nanotechnology.
FAU - Perez Alvarez, Salvador
AU  - Perez Alvarez S
AD  - Facultad de Derecho, UNED.
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Paradigmas meta-juridicos de la Nanomedicina.
PL  - Spain
TA  - Rev Derecho Genoma Hum
JT  - Revista de derecho y genoma humano = Law and the human genome review
JID - 101558644
SB  - IM
MH  - Humans
MH  - Nanomedicine/ethics/*legislation & jurisprudence
EDAT- 2013/03/26 06:00
MHDA- 2013/04/30 06:00
CRDT- 2013/03/26 06:00
PHST- 2013/03/26 06:00 [entrez]
PHST- 2013/03/26 06:00 [pubmed]
PHST- 2013/04/30 06:00 [medline]
PST - ppublish
SO  - Rev Derecho Genoma Hum. 2012 Jul-Dec;(37):61-91.


PMID- 23520913
OWN - NLM
STAT- MEDLINE
DCOM- 20130429
LR  - 20161021
IS  - 1134-7198 (Print)
IS  - 1134-7198 (Linking)
IP  - 37
DP  - 2012 Jul-Dec
TI  - Legal aspects of genetic databases for international biomedical research: the
      example of the International Cancer Genome Consortium (ICGC).
PG  - 15-34
AB  - There is a noticeable lack of international regulation on personal data exchange 
      and management in research. This article sheds light in this area by describing
      how the International Cancer Genome Consortium is developing policies and
      procedures to address the ethical and legal issues raised by the international
      transfer of data and results. These policies and procedures aim, first and most
      importantly, to safeguard the interests of the research participants and other
      involved stakeholders and, secondly, to facilitate the sharing of data and
      results to realize greater benefits from this kind of internationally
      collaborative genetic research.
FAU - Romeo-Casabona, Carlos
AU  - Romeo-Casabona C
AD  - ICGC. carlosmaria.romeo@ehu.es
FAU - Nicolas, Pilar
AU  - Nicolas P
FAU - Knoppers, Bartha Maria
AU  - Knoppers BM
FAU - Joly, Yann
AU  - Joly Y
FAU - Wallace, Susan E
AU  - Wallace SE
FAU - Chalmers, Don
AU  - Chalmers D
FAU - Dyke, Stephanie
AU  - Dyke S
FAU - Kennedy, Karen
AU  - Kennedy K
FAU - Troncoso, Antonio
AU  - Troncoso A
FAU - Kaan, Terry
AU  - Kaan T
FAU - Rial-Sebbag, Emmanuelle
AU  - Rial-Sebbag E
CN  - VV.AA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Spain
TA  - Rev Derecho Genoma Hum
JT  - Revista de derecho y genoma humano = Law and the human genome review
JID - 101558644
SB  - IM
MH  - Biomedical Research/*legislation & jurisprudence
MH  - Databases, Genetic/ethics/*legislation & jurisprudence
MH  - Genetic Research/*legislation & jurisprudence
MH  - International Agencies
MH  - Internationality
EDAT- 2013/03/26 06:00
MHDA- 2013/04/30 06:00
CRDT- 2013/03/26 06:00
PHST- 2013/03/26 06:00 [entrez]
PHST- 2013/03/26 06:00 [pubmed]
PHST- 2013/04/30 06:00 [medline]
PST - ppublish
SO  - Rev Derecho Genoma Hum. 2012 Jul-Dec;(37):15-34.


PMID- 23520678
OWN - NLM
STAT- MEDLINE
DCOM- 20130430
LR  - 20130325
IS  - 0019-5847 (Print)
IS  - 0019-5847 (Linking)
VI  - 110
IP  - 7
DP  - 2012 Jul
TI  - Family physicians: importance and relevance.
PG  - 490-3
AB  - Due to rapid advancement in medical technology and knowledge patients today
      prefer treatment from specialists, if they can afford it. Medical treatment has
      become a purchasable commodity, to be procured as and when required, based on
      cost and availability.This is unfortunate but true. Specialisation tends to
      divide the patients into'parts' and increases the cost of treatment. Moreover no 
      single physician is in charge of the patient as a whole to maintain long term
      continuity and coordinate the treatments given by different specialists. Since
      long term dependence on 'family doctor' has reduced, trust deficit in the
      profession has started creeping in. It is essential to rejuvenate the concept of 
      family doctors equipped with skills suitable for modern technology and practice, 
      to restore the faith of patients in medical professionals. Family doctor can
      provide a 'single window clearance' for all healthcare needs of an individual.
      Exploitation of gullible patient can be prevented when the family doctor becomes 
      the friend and guide for all treatments being given to the individual. Society
      should be educated on the benefits of getting the treatment through the family
      doctor. The family doctor then becomes the Authorised Medical Attendant (AMA),
      responsible for all treatments beings provided to the patients. The Medical
      Council of India (MCI) may consider incorporating this in code of medical ethics.
FAU - Yeravdekar, Rajiv
AU  - Yeravdekar R
AD  - Faculty of Health Sciences, Symbiosis International University (SIU), Pune
      411004.
FAU - Yeravdekar, Vidya Rajiv
AU  - Yeravdekar VR
FAU - Tutakne, M A
AU  - Tutakne MA
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Indian Med Assoc
JT  - Journal of the Indian Medical Association
JID - 7505608
SB  - IM
MH  - Cooperative Behavior
MH  - *Developing Countries
MH  - *Diffusion of Innovation
MH  - Education, Medical, Continuing
MH  - Health Services Needs and Demand
MH  - Humans
MH  - India
MH  - Interdisciplinary Communication
MH  - Medicine
MH  - *Physician's Role
MH  - *Physicians, Family/education
MH  - *Referral and Consultation
EDAT- 2013/03/26 06:00
MHDA- 2013/05/01 06:00
CRDT- 2013/03/26 06:00
PHST- 2013/03/26 06:00 [entrez]
PHST- 2013/03/26 06:00 [pubmed]
PHST- 2013/05/01 06:00 [medline]
PST - ppublish
SO  - J Indian Med Assoc. 2012 Jul;110(7):490-3.


PMID- 23519067
OWN - NLM
STAT- MEDLINE
DCOM- 20130627
LR  - 20191112
IS  - 1750-8460 (Print)
IS  - 1750-8460 (Linking)
VI  - 73
IP  - 12
DP  - 2012 Dec
TI  - Understanding autonomy within philosophical tradition and modern medical ethics.
PG  - C190-2
FAU - Stephenson, Lucy A
AU  - Stephenson LA
AD  - Bethlem Royal Hospital, Beckenham, UK. lucy.stephenson@kcl.ac.uk
FAU - Wagner, Stefan J
AU  - Wagner SJ
FAU - Bolton, Derek
AU  - Bolton D
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Hosp Med (Lond)
JT  - British journal of hospital medicine (London, England : 2005)
JID - 101257109
SB  - IM
MH  - Ethics, Medical
MH  - Humans
MH  - Patient Rights/ethics
MH  - *Personal Autonomy
MH  - Physician-Patient Relations/ethics
MH  - *Principle-Based Ethics
EDAT- 2013/03/23 06:00
MHDA- 2013/06/29 06:00
CRDT- 2013/03/23 06:00
PHST- 2013/03/23 06:00 [entrez]
PHST- 2013/03/23 06:00 [pubmed]
PHST- 2013/06/29 06:00 [medline]
AID - 10.12968/hmed.2012.73.sup12.c190 [doi]
PST - ppublish
SO  - Br J Hosp Med (Lond). 2012 Dec;73(12):C190-2. doi:
      10.12968/hmed.2012.73.sup12.c190.


PMID- 23515767
OWN - NLM
STAT- MEDLINE
DCOM- 20140203
LR  - 20191112
IS  - 1980-5497 (Electronic)
IS  - 1415-790X (Linking)
VI  - 15
IP  - 4
DP  - 2012 Dec
TI  - E-survey with researchers, members of ethics committees and sponsors of clinical 
      research in Brazil: an emerging methodology for scientific research.
PG  - 705-13
LID - S1415-790X2012000400003 [pii]
AB  - INTRODUCTION: The growth of Internet users enables epidemiological studies to be 
      conducted electronically, representing a promising methodology for data
      collection. METHODS: Members of Ethics Committees, Clinical Researchers and
      Sponsors were interviewed using questionnaires sent over the Internet. Along with
      the questionnaire, participants received a message explaining the survey and also
      the informed consent. Returning the questionnaire meant the consent of the
      participant was given. No incentive was offered; two reminders were sent.
      RESULTS: The response rate was 21% (124/599), 20% (58/290) and 45% (24/53)
      respectively for Ethics Committees, Researchers and Sponsors. The percentage of
      return before the two reminders was about 62%. Reasons for non-response:
      participant not found, refusal to participate, lack of experience in clinical
      research or in the therapeutic field. Characteristics of participants: 45% of
      Ethics Committee participants, 64% of Researchers and 63% of Sponsors were male; 
      mean age (range), respectively: 47 (28-74), 53 (24-72) and 40 (29-65) years.
      Among Researchers and Sponsors, all respondents had at least a university degree 
      and, in the Ethics Committees group, only two (1.7%) did not have one. Most of
      the questionnaires in all groups came from the Southeast Region of Brazil,
      probably reflecting the highest number of clinical trials and research
      professionals in this region. CONCLUSION: Despite the potential limitations of a 
      survey done through the Internet, this study led to a response rate similar to
      what has been observed with other models, efficiency in obtaining responses
      (speed and quality), convenience for respondents and low cost.
FAU - Dainesi, Sonia Mansoldo
AU  - Dainesi SM
AD  - Department of Preventive Medicine, Sao Paulo University, Brazil.
      sdainesi@gmail.com
FAU - Goldbaum, Moises
AU  - Goldbaum M
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - Rev Bras Epidemiol
JT  - Revista brasileira de epidemiologia = Brazilian journal of epidemiology
JID - 100954576
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomedical Research/*methods
MH  - Brazil
MH  - *Ethics Committees
MH  - Female
MH  - Government Programs
MH  - Humans
MH  - *Internet
MH  - Male
MH  - Middle Aged
MH  - *Research Personnel
MH  - *Surveys and Questionnaires
MH  - Young Adult
EDAT- 2013/03/22 06:00
MHDA- 2014/02/04 06:00
CRDT- 2013/03/22 06:00
PHST- 2011/08/17 00:00 [received]
PHST- 2012/03/16 00:00 [accepted]
PHST- 2013/03/22 06:00 [entrez]
PHST- 2013/03/22 06:00 [pubmed]
PHST- 2014/02/04 06:00 [medline]
AID - S1415-790X2012000400003 [pii]
AID - 10.1590/s1415-790x2012000400003 [doi]
PST - ppublish
SO  - Rev Bras Epidemiol. 2012 Dec;15(4):705-13. doi: 10.1590/s1415-790x2012000400003.


PMID- 23515242
OWN - NLM
STAT- MEDLINE
DCOM- 20130806
LR  - 20211021
IS  - 1729-0503 (Electronic)
IS  - 1680-6905 (Linking)
VI  - 12
IP  - 4
DP  - 2012 Dec
TI  - Female genital mutilation in Djibouti.
PG  - 412-5
AB  - The practice of female genital mutilation (we will use the latest definition
      adopted by WHO/UNFP: female genital mutilation/cutting or FGM/C) is still
      widespread in 28 African countries. The World Health Organisation (WHO) estimates
      that more than two million females undergo some form of genital mutilation every 
      year. Its negative health impact and its ethical and human rights aspects have
      been discussed and attempts to eliminate it have been the objectives of several
      meetings promoted by national and international organisations thanks to an
      increased awareness related to FGM/C in those countries practicing it and also,
      maybe due to the number of Africans migrating to industrialized countries. We
      review the present situation in Djibouti, a small country in the Horn of Africa, 
      where 98 % of the female population has suffered different forms of FGM/C.
FAU - Martinelli, M
AU  - Martinelli M
AD  - Hopital Balbala, Djibouti.
FAU - Olle-Goig, J E
AU  - Olle-Goig JE
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Uganda
TA  - Afr Health Sci
JT  - African health sciences
JID - 101149451
SB  - IM
MH  - *Circumcision, Female
MH  - *Cultural Characteristics
MH  - Djibouti
MH  - Female
MH  - Human Rights
MH  - Humans
PMC - PMC3598278
OTO - NOTNLM
OT  - Djibouti
OT  - female genital mutilation/cutting
EDAT- 2013/03/22 06:00
MHDA- 2013/08/07 06:00
CRDT- 2013/03/22 06:00
PHST- 2013/03/22 06:00 [entrez]
PHST- 2013/03/22 06:00 [pubmed]
PHST- 2013/08/07 06:00 [medline]
AID - 10.4314/ahs.v12i4.2 [doi]
PST - ppublish
SO  - Afr Health Sci. 2012 Dec;12(4):412-5. doi: 10.4314/ahs.v12i4.2.


PMID- 23513077
OWN - NLM
STAT- MEDLINE
DCOM- 20130806
LR  - 20211021
IS  - 1729-0503 (Electronic)
IS  - 1680-6905 (Linking)
VI  - 12
IP  - 4
DP  - 2012 Dec
TI  - Construct validation of an instrument to measure patient satisfaction with
      pharmacy services in Nigerian hospitals.
PG  - 538-44
AB  - BACKGROUND: Patient satisfaction is a multidimensional construct that reflects
      the type and quality of service provided by healthcare providers, how well it is 
      delivered, and the extent to which the expectations and needs of patients are
      met. As a performance measure, patient satisfaction has been defined as the
      personal evaluation of health care services and providers. OBJECTIVE: To develop 
      a patient satisfaction scale, that could be used to assess the quality of
      pharmacy services provided in Nigerian hospitals and to determine the construct
      validity of the scale with a view to identifying the factors that may be
      considered relevant to the target users. METHODS: The questionnaire was a 35-item
      inventory titled "Patient Satisfaction Survey (PSS)". This study was carried out 
      in three university teaching hospitals located in Southwestern Nigeria. The
      patient satisfaction survey instrument (PSS) was administered on 506 clinic
      outpatients who patronised the hospital pharmacies. Participation in the study
      was voluntary with appropriate informed consent. Ethical approval was obtained
      for this study from the Medical and Ethics Committee of Obafemi Awolowo
      University Teaching Hospital Complex (OAUTHC). RESULTS: Patients with post
      secondary education were in the majority with a frequency of 224 (44.3%)
      subjects. This was followed by a frequency of 116 (22.9%) for those with
      secondary education. Eighty-seven (17.2%) of those included in the main study had
      primary education 64 (12.7%) did not receive any formal education. Fifteen (3%)
      out of the 506 sampled did not indicate their level of education. CONCLUSION:
      This study developed a scale to measure patient satisfaction with pharmaceutical 
      services in selected Nigerian university teaching hospitals. The final 25 item
      scale presents significant and stable coefficients of correlation and yielded six
      derived dimensions of patient satisfaction.
FAU - Afolabi, M O
AU  - Afolabi MO
AD  - Department of Clinical Pharmacy & Pharmacy Administration Unit, Obafemi Awolowo
      University, IIe Ife, Nigeria. bunmafol@yahoo.com
FAU - Afolabi, E R I
AU  - Afolabi ER
FAU - Faleye, B A
AU  - Faleye BA
LA  - eng
PT  - Journal Article
PL  - Uganda
TA  - Afr Health Sci
JT  - African health sciences
JID - 101149451
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Health Care Surveys
MH  - Hospitals, Teaching
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nigeria
MH  - Patient Satisfaction/*statistics & numerical data
MH  - Pharmacists
MH  - Pharmacy Service, Hospital/*standards
MH  - Psychometrics/statistics & numerical data
MH  - Reproducibility of Results
MH  - Statistics, Nonparametric
MH  - Surveys and Questionnaires/*standards
PMC - PMC3598297
EDAT- 2013/03/21 06:00
MHDA- 2013/08/07 06:00
CRDT- 2013/03/21 06:00
PHST- 2013/03/21 06:00 [entrez]
PHST- 2013/03/21 06:00 [pubmed]
PHST- 2013/08/07 06:00 [medline]
AID - 10.4314/ahs.v12i4.22 [doi]
PST - ppublish
SO  - Afr Health Sci. 2012 Dec;12(4):538-44. doi: 10.4314/ahs.v12i4.22.


PMID- 23505339
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1541-0099 (Print)
IS  - 1541-0099 (Linking)
VI  - 22
IP  - 1
DP  - 2012 Jun
TI  - Baby Steps to Superintelligence: Neuroprosthetics and Children.
PG  - 132-145
AB  - Children surviving neural injuries face challenges not seen by their adult
      counterparts, namely that they experience neural injury before reaching
      neurodevelopmental maturity. Neural prostheses offer one possible path to
      recovery, along with the potential for functional outcomes that could exceed
      expectations. Although the first cochlear implant was placed more than fifty
      years ago, the field of neuroprosthetics is still relatively young. Several types
      of neural prostheses are in development stages ranging from animal models to
      (adult) human trials. In this paper, I discuss how neural prostheses may assist
      recovery for children surviving neural injury. I argue that approaching the use
      of neural prosthetics in children with considerations derived from transhumanism 
      alongside traditional bioethics can provide an opportunity to reframe
      adult-focused ethics toward a child/family focus and to strip away the
      prejudicial metaphor of cyborgization.
FAU - Lucas, Matthew S
AU  - Lucas MS
AD  - School of Nursing and School of Medicine, University of Pennsylvania.
LA  - eng
GR  - F31 NR013091/NR/NINR NIH HHS/United States
GR  - T32 NR007100/NR/NINR NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - J Evol Technol
JT  - Journal of evolution and technology
JID - 101222976
PMC - PMC3595610
MID - NIHMS425005
EDAT- 2013/03/19 06:00
MHDA- 2013/03/19 06:01
CRDT- 2013/03/19 06:00
PHST- 2013/03/19 06:00 [entrez]
PHST- 2013/03/19 06:00 [pubmed]
PHST- 2013/03/19 06:01 [medline]
PST - ppublish
SO  - J Evol Technol. 2012 Jun;22(1):132-145.


PMID- 23497813
OWN - NLM
STAT- MEDLINE
DCOM- 20140219
LR  - 20130318
IS  - 1873-6963 (Electronic)
IS  - 0965-2299 (Linking)
VI  - 21
IP  - 2
DP  - 2013 Apr
TI  - The use of placebo interventions in clinical practice.
PG  - 109-11
LID - 10.1016/j.ctim.2012.11.010 [doi]
LID - S0965-2299(12)00166-5 [pii]
AB  - Although a considerable number of mostly quantitative surveys have investigated
      the frequency and circumstances of the use of placebo interventions in clinical
      practice, it remains rather unclear what role placebo interventions really have
      outside clinical and laboratory research and why they are used. In this article I
      discuss two aspects which have to be taken into account when future research aims
      to provide further insights: (1) the different perspectives of patients,
      providers and scientists when it comes to decide whether a treatment is a placebo
      or not and (2) the fact that applying placebos intentionally is not only an
      ethical but also a professional problem.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Linde, K
AU  - Linde K
AD  - Institute of General Practice, Technische Universitat Munchen, 81667 Munich,
      Germany. Klaus.Linde@lrz.tum.de
LA  - eng
PT  - Journal Article
DEP - 20121225
PL  - Scotland
TA  - Complement Ther Med
JT  - Complementary therapies in medicine
JID - 9308777
RN  - 0 (Materia Medica)
RN  - 0 (Placebos)
SB  - IM
MH  - Clinical Medicine/methods
MH  - Data Collection
MH  - Humans
MH  - Materia Medica/administration & dosage
MH  - Pain/drug therapy/psychology
MH  - *Placebo Effect
MH  - Placebos/*administration & dosage
MH  - Research Design
EDAT- 2013/03/19 06:00
MHDA- 2014/02/20 06:00
CRDT- 2013/03/19 06:00
PHST- 2012/09/05 00:00 [received]
PHST- 2012/10/08 00:00 [revised]
PHST- 2012/11/27 00:00 [accepted]
PHST- 2013/03/19 06:00 [entrez]
PHST- 2013/03/19 06:00 [pubmed]
PHST- 2014/02/20 06:00 [medline]
AID - S0965-2299(12)00166-5 [pii]
AID - 10.1016/j.ctim.2012.11.010 [doi]
PST - ppublish
SO  - Complement Ther Med. 2013 Apr;21(2):109-11. doi: 10.1016/j.ctim.2012.11.010. Epub
      2012 Dec 25.


PMID- 23497808
OWN - NLM
STAT- MEDLINE
DCOM- 20140219
LR  - 20181202
IS  - 1873-6963 (Electronic)
IS  - 0965-2299 (Linking)
VI  - 21
IP  - 2
DP  - 2013 Apr
TI  - The placebo effect and its ramifications for clinical practice and research.
      Villa La Collina at Lake Como, Italy, 4-6 May 2012.
PG  - 85-93
LID - 10.1016/j.ctim.2012.11.005 [doi]
LID - S0965-2299(12)00161-6 [pii]
AB  - INTRODUCTION: The purpose of this workshop was to further explore the
      implications of the placebo effect for both research and clinical practice from a
      variety of angles with a group of selected experts. METHOD/APPROACH: The use of
      placebos in both clinical practice and research was explored in depth from a
      historical, methodological, ethical, legal and cultural point of view. The
      current state of knowledge regarding the placebo effect was established,
      knowledge gaps were identified, and the implications for both clinical research
      and practice were discussed in depth. KEY MESSAGES: * Placebos have been
      consciously used in clinical practice since the 18th century, but only emerged as
      a research topic in the western world in the second half of the 20th century. *
      The placebo response consists of the placebo effect plus the natural course of
      the disease, and is a meaningful part of all medical treatments. * A variety of
      not fully understood individual, context and cultural factors contribute to the
      placebo response and interact in a non-linear way with the specific effects of
      medicines. * The assessment of a therapeutic effect in placebo-controlled RCTs is
      often difficult due to a strong placebo response, e.g. in Central Nervous System 
      (CNS) indications like major depression or in Irritable Bowel Syndrome. * Placebo
      effects occur, and can affect the validity and appropriateness of placebo
      controlled trials in conventional as well as Complementary and Alternative
      Medicine (CAM) research. * It may be impossible to fully disentangle the verum
      and sham effects of both CAM and conventional medical procedures such as for
      instance acupuncture and surgery. * Context/meaning effects, including doctor
      empathy, are highly relevant and under-researched in both conventional and
      complementary medicine. * The use of 'impure placebos' (non-indicated/ineffective
      medicines) in clinical practice may be common, but little reliable data is
      available due to complexities around the definition of impure placebos and
      underreporting. * The assumption that placebo effects do not occur in veterinary 
      research is likely to be incorrect, e.g. owner empathy and vet expectations can
      affect outcomes. * Various innovative trial designs that better deal with the
      placebo issue are available, but only as partial solutions. * Patient treatment
      will benefit from better understanding and appropriately utilising
      meaning/context effects. CONCLUSIONS: There are many remaining knowledge gaps
      with regard to the placebo response. The evolving knowledge challenges the
      paradigm of the placebo controlled RCT as a gold standard for demonstrating
      benefit of treatments. There are a number of pointers towards alternative
      research designs and paradigms worthy of further exploration. The evolving
      knowledge can contribute to the further development of a 'meaning orientated' and
      patient centred healthcare system.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - van Haselen, Robbert
AU  - van Haselen R
AD  - Complementary Therapies in Medicine, 22 Eden Street, Suite 467, Kingston KT1 1DN,
      United Kingdom. vanhaselen.ctim@intmedi.com
FAU - Jutte, Robert
AU  - Jutte R
LA  - eng
PT  - Congress
PT  - Research Support, Non-U.S. Gov't
DEP - 20121229
PL  - Scotland
TA  - Complement Ther Med
JT  - Complementary therapies in medicine
JID - 9308777
SB  - IM
MH  - Humans
MH  - *Placebo Effect
MH  - Randomized Controlled Trials as Topic/*methods
MH  - Research Design
EDAT- 2013/03/19 06:00
MHDA- 2014/02/20 06:00
CRDT- 2013/03/19 06:00
PHST- 2012/08/05 00:00 [received]
PHST- 2012/11/21 00:00 [revised]
PHST- 2012/11/22 00:00 [accepted]
PHST- 2013/03/19 06:00 [entrez]
PHST- 2013/03/19 06:00 [pubmed]
PHST- 2014/02/20 06:00 [medline]
AID - S0965-2299(12)00161-6 [pii]
AID - 10.1016/j.ctim.2012.11.005 [doi]
PST - ppublish
SO  - Complement Ther Med. 2013 Apr;21(2):85-93. doi: 10.1016/j.ctim.2012.11.005. Epub 
      2012 Dec 29.


PMID- 23493836
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 2150-7716 (Print)
IS  - 2150-7724 (Linking)
VI  - 3
IP  - 3
DP  - 2012 Jul 1
TI  - Informed Consent in Genome-Scale Research: What Do Prospective Participants
      Think?
PG  - 3-11
AB  - BACKGROUND: To promote effective genome-scale research, genomic and clinical data
      for large population samples must be collected, stored, and shared. METHODS: We
      conducted focus groups with 45 members of a Seattle-based integrated healthcare
      delivery system to learn about their views and expectations for informed consent 
      in genome-scale studies. RESULTS: Participants viewed information about study
      purpose, aims, and how and by whom study data could be used to be at least as
      important as information about risks and possible harms. They generally supported
      a tiered consent approach for specific issues, including research purpose, data
      sharing, and access to individual research results. Participants expressed a
      continuum of opinions with respect to the acceptability of broad consent, ranging
      from completely acceptable to completely unacceptable. Older participants were
      more likely to view the consent process in relational - rather than contractual -
      terms, compared with younger participants. The majority of participants endorsed 
      seeking study subjects' permission regarding material changes in study purpose
      and data sharing. CONCLUSIONS: Although this study sample was limited in terms of
      racial and socioeconomic diversity, our results suggest a strong positive
      interest in genomic research on the part of at least some prospective
      participants and indicate a need for increased public engagement, as well as
      strategies for ongoing communication with study participants.
FAU - Trinidad, Susan Brown
AU  - Trinidad SB
AD  - University of Washington.
FAU - Fullerton, Stephanie M
AU  - Fullerton SM
FAU - Bares, Julie M
AU  - Bares JM
FAU - Jarvik, Gail P
AU  - Jarvik GP
FAU - Larson, Eric B
AU  - Larson EB
FAU - Burke, Wylie
AU  - Burke W
LA  - eng
GR  - U01 AG006781/AG/NIA NIH HHS/United States
GR  - U01 HG004610/HG/NHGRI NIH HHS/United States
GR  - U01 HG006375/HG/NHGRI NIH HHS/United States
PT  - Journal Article
DEP - 20120619
PL  - United States
TA  - AJOB Prim Res
JT  - AJOB primary research
JID - 101520734
PMC - PMC3593675
MID - NIHMS386981
OTO - NOTNLM
OT  - Informed consent
OT  - biobank
OT  - genomic research
OT  - participant views
OT  - research ethics
EDAT- 2013/03/16 06:00
MHDA- 2013/03/16 06:01
CRDT- 2013/03/16 06:00
PHST- 2013/03/16 06:00 [entrez]
PHST- 2013/03/16 06:00 [pubmed]
PHST- 2013/03/16 06:01 [medline]
AID - 10.1080/21507716.2012.662575 [doi]
PST - ppublish
SO  - AJOB Prim Res. 2012 Jul 1;3(3):3-11. doi: 10.1080/21507716.2012.662575. Epub 2012
      Jun 19.


PMID- 23493618
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130318
LR  - 20220330
IS  - 2008-3866 (Print)
IS  - 2008-3866 (Linking)
VI  - 15
IP  - 5
DP  - 2012 Sep
TI  - Publication Ethics: A Case Series with Recommendations According to Committee on 
      Publication Ethics (COPE).
PG  - 1003-7
AB  - Ethical misconduct is not a new issue in the history of science and literature.
      However, ethical misconducts in science have grown considerably in the modern era
      which is due to emphasis on the scientific proliferation in research institutes
      and gauging scientists according to their publications. In the current case
      series, several misconducts occurring over the previous years in Mashhad
      University of Medical Sciences (Mashhad, Iran) either for Journals or Faculty
      members were gathered and specific recommendations were provided to avoid similar
      events in the future. All recommendations are according to Committee on
      Publication Ethics (COPE).
FAU - Fazly Bazzaz, Bibi Seddigheh
AU  - Fazly Bazzaz BS
AD  - Biotechnology Research Centre, School of Pharmacy, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
FAU - Sadeghi, Ramin
AU  - Sadeghi R
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Basic Med Sci
JT  - Iranian journal of basic medical sciences
JID - 101517966
PMC - PMC3586923
OTO - NOTNLM
OT  - Authorship criteria
OT  - Copyright transfer
OT  - Data fabrication
OT  - Plagiarism
OT  - Publication ethics
EDAT- 2013/03/16 06:00
MHDA- 2013/03/16 06:01
CRDT- 2013/03/16 06:00
PHST- 2013/03/16 06:00 [entrez]
PHST- 2013/03/16 06:00 [pubmed]
PHST- 2013/03/16 06:01 [medline]
PST - ppublish
SO  - Iran J Basic Med Sci. 2012 Sep;15(5):1003-7.


PMID- 23488373
OWN - NLM
STAT- MEDLINE
DCOM- 20130401
LR  - 20130315
IS  - 0029-6570 (Print)
IS  - 0029-6570 (Linking)
VI  - 27
IP  - 13
DP  - 2012 Nov 28-Dec 4
TI  - Ethical practice in nursing care.
PG  - 51-6; quiz 58
AB  - Ethical practice is acknowledged as an essential feature of good nursing, yet
      defining what comprises such practice is complex. This article examines aspects
      of ethical practice from the perspectives of healthcare professionals, service
      users and carers. The relationship between ethical practice and decision making
      is discussed, recognising the importance of context and the responsibilities of
      the nurse. To demonstrate ethical practice, the nurse needs to act as a moral
      agent. Practising ethically means not only knowing the right thing to do, but
      also being prepared to put this into action. With this in mind, the complexities 
      of ethical practice and opportunities to practise skills in ethical reasoning are
      explored.
FAU - Holt, Janet
AU  - Holt J
AD  - School of Healthcare, University of Leeds. hcsjh@leeds.ac.uk
FAU - Convey, Helen
AU  - Convey H
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Stand
JT  - Nursing standard (Royal College of Nursing (Great Britain) : 1987)
JID - 9012906
MH  - Decision Making
MH  - Education, Nursing, Continuing
MH  - *Ethics, Nursing
MH  - Humans
MH  - *Nursing Care
EDAT- 2013/03/16 06:00
MHDA- 2013/04/02 06:00
CRDT- 2013/03/16 06:00
PHST- 2013/03/16 06:00 [entrez]
PHST- 2013/03/16 06:00 [pubmed]
PHST- 2013/04/02 06:00 [medline]
AID - 10.7748/ns2012.11.27.13.51.c9451 [doi]
PST - ppublish
SO  - Nurs Stand. 2012 Nov 28-Dec 4;27(13):51-6; quiz 58. doi:
      10.7748/ns2012.11.27.13.51.c9451.


PMID- 23488216
OWN - NLM
STAT- MEDLINE
DCOM- 20130409
LR  - 20220129
IS  - 0265-539X (Print)
IS  - 0265-539X (Linking)
VI  - 29
IP  - 4
DP  - 2012 Dec
TI  - Letter from America: UK and US state-funded dental provision.
PG  - 315-20
AB  - OBJECTIVES: Current UK and US economic conditions have re-focussed attention on
      the need to deliver dental care with limited finance and resources. This raises
      hard questions determining which services will be offered and what they should
      achieve to satisfy public demands and needs. We consider impending dental health 
      reforms in the US and UK within the context of contemporary experiences to
      identify issues and delivery goals for the two nations. BACKGROUND: The paper
      provides a brief history and background of the development of social dental care 
      models in the UK and US, highlighting some differences in state-funded delivery
      of dental care. SHIFTING DEMAND: From the 1950s, demand for dental treatment has 
      increased and acquired a more complex composition growing from predominantly
      surgical and restorative treatment to encompass preventive care and cosmetic
      services. PRIORITISING CARE ACCORDING TO NEED: Despite improvements in general
      health and technology, inequalities in access and utilisation of dental care are 
      still experienced, primarily by groups with low socio-economic status. DELIVERY: 
      BALANCING RESOURCES, DEMAND AND NEED: In developing and delivering reform
      agendas, much can be learned from previous policy interventions. Pressures of
      cost, coverage, and capacity, besides demand versus need must be carefully
      considered and balanced to deliver quality service and value for users and
      taxpayers. CONCLUSIONS: Ethical and moral consideration should be given to making
      services needs-driven to address high treatment requirements rather than the high
      care demands of the worried well. This challenge brings the additional political 
      pressure of convincing many of the voters (and subsequent complainers) that their
      demands may be less important than the needs of others.
FAU - Currie, R B
AU  - Currie RB
AD  - School of Dentistry, University of Manchester UK.
      richard.currie-2@postgrad.manchester.ac.uk
FAU - Pretty, I A
AU  - Pretty IA
FAU - Tickle, M
AU  - Tickle M
FAU - Maupome, G
AU  - Maupome G
LA  - eng
GR  - DHCS/05/05/008/DH_/Department of Health/United Kingdom
PT  - Journal Article
PL  - England
TA  - Community Dent Health
JT  - Community dental health
JID - 8411261
SB  - IM
MH  - Dental Health Services/classification/*economics/statistics & numerical data
MH  - Ethics, Dental
MH  - Health Care Costs
MH  - Health Care Reform/organization & administration
MH  - Health Care Sector
MH  - Health Expenditures
MH  - Health Policy
MH  - Health Priorities
MH  - Health Resources
MH  - Health Services Accessibility
MH  - Health Services Needs and Demand
MH  - Healthcare Disparities
MH  - *Healthcare Financing
MH  - Humans
MH  - Insurance, Health/organization & administration
MH  - Organizational Objectives
MH  - Patient Protection and Affordable Care Act/organization & administration
MH  - Preventive Dentistry/organization & administration
MH  - Primary Health Care
MH  - Private Sector
MH  - Quality of Health Care
MH  - Social Class
MH  - State Dentistry/organization & administration
MH  - United Kingdom
MH  - United States
EDAT- 2013/03/16 06:00
MHDA- 2013/04/10 06:00
CRDT- 2013/03/16 06:00
PHST- 2013/03/16 06:00 [entrez]
PHST- 2013/03/16 06:00 [pubmed]
PHST- 2013/04/10 06:00 [medline]
PST - ppublish
SO  - Community Dent Health. 2012 Dec;29(4):315-20.


PMID- 23488210
OWN - NLM
STAT- MEDLINE
DCOM- 20130409
LR  - 20220129
IS  - 0265-539X (Print)
IS  - 0265-539X (Linking)
VI  - 29
IP  - 4
DP  - 2012 Dec
TI  - Children's views on the experience of a visual examination and intra-oral
      photographs to detect dental caries in epidemiological studies.
PG  - 284-8
AB  - AIM: To elicit children's views on the established visual examination method used
      for the epidemiological surveillance of dental caries and an experimental
      intra-oral photographic examination method. METHOD: Focus group interviews were
      conducted with 5-year-olds (with the aid of a puppet) and 10/11-year-olds
      (without puppet) after experiencing both methods. Ten focus groups were conducted
      in each cohort. RESULTS: The children's views on the methods related to the
      acceptability of their experience. The key factors affecting acceptability and
      preferences related to the combined effects of contextual factors prior to the
      examination and experiences during the examination. These included communication 
      and children's expectations. These factors influenced the examination experience 
      along with their feelings about the environment and the tactile sensation from
      instruments in the mouth. Most children preferred the experimental photographic
      method as a means of caries detection over the traditional visual examination.
      They also wanted feedback on their oral health and more communication on what was
      happening during the examination. CONCLUSION Appropriate communication, attention
      to the examination environment and handling of instruments can enhance the dental
      examination experience for children in the school setting. The children's
      preferences indicated that generally, the intra-oral camera was well received as 
      a means of caries detection for epidemiological studies within the school
      setting. These results may have implications for seeking ethical approval and
      conducting epidemiological studies on children in the future.
FAU - Boye, U
AU  - Boye U
AD  - The Oral Health Unit, School of Dentistry, University of Manchester, Manchester
      Academic Health Sciences Center Manchester, UK. tboye@btinternet.com
FAU - Foster, G R K
AU  - Foster GR
FAU - Pretty, I A
AU  - Pretty IA
FAU - Tickle, M
AU  - Tickle M
LA  - eng
GR  - DHCS/05/05/008/DH_/Department of Health/United Kingdom
PT  - Journal Article
PL  - England
TA  - Community Dent Health
JT  - Community dental health
JID - 8411261
SB  - IM
MH  - *Attitude to Health
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Communication
MH  - Dental Caries/*diagnosis
MH  - Dental Instruments
MH  - Dentist-Patient Relations
MH  - Emotions
MH  - Epidemiologic Studies
MH  - Feedback
MH  - Female
MH  - Focus Groups
MH  - Health Facility Environment
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Patient Acceptance of Health Care
MH  - Patient Preference
MH  - *Photography, Dental
MH  - *Physical Examination
MH  - School Dentistry
MH  - Touch
EDAT- 2013/03/16 06:00
MHDA- 2013/04/10 06:00
CRDT- 2013/03/16 06:00
PHST- 2013/03/16 06:00 [entrez]
PHST- 2013/03/16 06:00 [pubmed]
PHST- 2013/04/10 06:00 [medline]
PST - ppublish
SO  - Community Dent Health. 2012 Dec;29(4):284-8.


PMID- 23483705
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1931-3918 (Print)
IS  - 1931-3918 (Linking)
VI  - 6
IP  - 3
DP  - 2012 Aug 1
TI  - Learning From The Past and Planning For The Future: The Challenges Of And
      Solutions For Integrating Aging Into Doctoral Psychology Training.
PG  - 142-150
AB  - The long forecast "elder boom" has begun. Beginning in 2011, ten thousand members
      of the "baby boom" generation began turning 65 each day. This demographic shift
      in our society mandates that pre-doctoral programs in clinical psychology
      incorporate aging as an integral component of their core and elective training.
      While fully supporting the concept of broad and general training for predoctoral 
      professional psychology programs, we maintain that the infusion of aging into
      doctoral psychology training curricula has been inadequate. In this manuscript we
      provide an overview of geropsychology training models and discuss the challenges 
      involved in incorporating aging to the curriculum of pre-doctoral training in
      clinical psychology. Potential solutions and examples for accelerating infusion
      of aging knowledge base are discussed in the context of different geropsychology 
      training models. We conclude that providing services to this rapidly growing
      segment of our population presents both an employment opportunity to broaden the 
      reach of our profession as well as an ethical responsibility to train future
      professionals who will practice within their area of knowledge and expertise.
FAU - Holtzer, Roee
AU  - Holtzer R
AD  - Ferkauf Graduate School of Psychology, Yeshiva University ; Department of
      Neurology, Albert Einstein College of Medicine, Yeshiva University.
FAU - Zweig, Richard A
AU  - Zweig RA
FAU - Siegel, Lawrence J
AU  - Siegel LJ
LA  - eng
GR  - K23 AG030857/AG/NIA NIH HHS/United States
GR  - R01 AG036921/AG/NIA NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Train Educ Prof Psychol
JT  - Training and education in professional psychology
JID - 101465137
PMC - PMC3590915
MID - NIHMS412506
OTO - NOTNLM
OT  - Aging
OT  - Clinical psychology graduate training
OT  - Ethics
OT  - Gero-psychology
OT  - Professional Competence
OT  - Professional specialization
EDAT- 2013/03/14 06:00
MHDA- 2013/03/14 06:01
CRDT- 2013/03/14 06:00
PHST- 2013/03/14 06:00 [entrez]
PHST- 2013/03/14 06:00 [pubmed]
PHST- 2013/03/14 06:01 [medline]
AID - 10.1037/a0029365 [doi]
PST - ppublish
SO  - Train Educ Prof Psychol. 2012 Aug 1;6(3):142-150. doi: 10.1037/a0029365.


PMID- 23480834
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130419
LR  - 20220316
IS  - 1753-0067 (Electronic)
IS  - 1753-0059 (Linking)
VI  - 6
IP  - 6
DP  - 2012 Nov
TI  - Non-invasive prenatal diagnostics using next generation sequencing: technical,
      legal and social challenges.
PG  - 517-28
LID - 10.1517/17530059.2012.703650 [doi]
AB  - INTRODUCTION: Newly developed non-invasive prenatal diagnostic techniques, using 
      maternal blood samples, have the potential to reduce or obviate the need for
      invasive prenatal diagnostic practices such as amniocentesis or chorionic villous
      sampling. This will lead to a change in how obstetric care is extended by health 
      care providers to pregnant women at-risk of bearing an aneuploid child. AREAS
      COVERED: The process leading to the development of fetal aneuploidy detection via
      the analysis of cell-free DNA in maternal plasma by massive parallel sequencing. 
      Optimization of these strategies and approaches used in the recent or up-coming
      commercial launches. In addition, this review provides insight into legal
      implications, potential patent disputes, ethical and societal concerns raised by 
      this development, such as whole genome data storage, retrieval and access. EXPERT
      OPINION: There is a need for engagement by professional societies, to ensure
      correct usage of these newly emerging technologies and their restriction to
      high-risk pregnancies. National agencies need to ensure the necessary degree of
      high quality required for prenatal diagnosis.
FAU - Hahn, Sinuhe
AU  - Hahn S
AD  - University Hospital Basel, Department of Biomedicine/ Department of Obstetrics
      and Gynecology, Lab. Prenatal Medicine , Basel , Switzerland.
FAU - Hosli, Irene
AU  - Hosli I
FAU - Lapaire, Olav
AU  - Lapaire O
LA  - eng
PT  - Journal Article
DEP - 20120625
PL  - England
TA  - Expert Opin Med Diagn
JT  - Expert opinion on medical diagnostics
JID - 101392201
EDAT- 2013/03/14 06:00
MHDA- 2013/03/14 06:01
CRDT- 2013/03/14 06:00
PHST- 2013/03/14 06:00 [entrez]
PHST- 2013/03/14 06:00 [pubmed]
PHST- 2013/03/14 06:01 [medline]
AID - 10.1517/17530059.2012.703650 [doi]
PST - ppublish
SO  - Expert Opin Med Diagn. 2012 Nov;6(6):517-28. doi: 10.1517/17530059.2012.703650.
      Epub 2012 Jun 25.


PMID- 23472795
OWN - NLM
STAT- MEDLINE
DCOM- 20130919
LR  - 20130311
IS  - 1878-7487 (Electronic)
IS  - 1752-928X (Linking)
VI  - 20
IP  - 3
DP  - 2013 Apr
TI  - Statement on access to relevant medical and other health records and relevant
      legal records for forensic medical evaluations of alleged torture and other
      cruel, inhuman or degrading treatment or punishment.
PG  - 158-63
LID - 10.1016/j.jflm.2012.07.005 [doi]
LID - S1752-928X(12)00175-8 [pii]
AB  - In some jurisdictions attempts have been made to limit or deny access to medical 
      records for victims of torture seeking remedy or reparations or for individuals
      who have been accused of crimes based on confessions allegedly extracted under
      torture. The following article describes the importance of full disclosure of all
      medical and other health records, as well as legal documents, in any case in
      which an individual alleges that they have been subjected to torture or other
      forms of cruel, inhuman or degrading treatment of punishment. A broad definition 
      of what must be included in the terms medical and health records is put forward, 
      and an overview of why their full disclosure is an integral part of international
      standards for the investigation and documentation of torture (the Istanbul
      Protocol). The fact that medical records may reveal the complicity or direct
      participation of healthcare professionals in acts of torture and other
      ill-treatment is discussed. A summary of international law and medical ethics
      surrounding the right of access to personal information, especially health
      information in connection with allegations of torture is also given.
CI  - Copyright (c) 2012 IRCT. Published by Elsevier Ltd and Faculty of Forensic and
      Legal Medicine. Published by Elsevier Ltd.. All rights reserved.
CN  - International Forensic Expert Group
FAU - Alempijevic, D
AU  - Alempijevic D
FAU - Beriashvili, R
AU  - Beriashvili R
FAU - Beynon, J
AU  - Beynon J
FAU - Duque, M
AU  - Duque M
FAU - Duterte, P
AU  - Duterte P
FAU - Fernando, R
AU  - Fernando R
FAU - Fincanci, S
AU  - Fincanci S
FAU - Hansen, S
AU  - Hansen S
FAU - Hardi, L
AU  - Hardi L
FAU - Hougen, H
AU  - Hougen H
FAU - Iacopino, V
AU  - Iacopino V
FAU - Mendonca, M
AU  - Mendonca M
FAU - Modvig, J
AU  - Modvig J
FAU - Mendez, M
AU  - Mendez M
FAU - Ozkalipci, O
AU  - Ozkalipci O
FAU - Payne-James, J
AU  - Payne-James J
FAU - Peel, M
AU  - Peel M
FAU - Rasmussen, O
AU  - Rasmussen O
FAU - Reyes, H
AU  - Reyes H
FAU - Rogde, S
AU  - Rogde S
FAU - Sajantila, A
AU  - Sajantila A
FAU - Treue, F
AU  - Treue F
FAU - Vanezis, P
AU  - Vanezis P
FAU - Vieira, D
AU  - Vieira D
LA  - eng
PT  - Journal Article
DEP - 20120809
PL  - England
TA  - J Forensic Leg Med
JT  - Journal of forensic and legal medicine
JID - 101300022
SB  - IM
MH  - Access to Information/*legislation & jurisprudence
MH  - Documentation
MH  - Ethics, Professional
MH  - Forensic Medicine/*legislation & jurisprudence
MH  - Humans
MH  - International Cooperation/*legislation & jurisprudence
MH  - Medical Records/*legislation & jurisprudence
MH  - Security Measures/legislation & jurisprudence
MH  - Torture/*legislation & jurisprudence
MH  - United Nations
EDAT- 2013/03/12 06:00
MHDA- 2013/09/21 06:00
CRDT- 2013/03/12 06:00
PHST- 2013/03/12 06:00 [entrez]
PHST- 2013/03/12 06:00 [pubmed]
PHST- 2013/09/21 06:00 [medline]
AID - S1752-928X(12)00175-8 [pii]
AID - 10.1016/j.jflm.2012.07.005 [doi]
PST - ppublish
SO  - J Forensic Leg Med. 2013 Apr;20(3):158-63. doi: 10.1016/j.jflm.2012.07.005. Epub 
      2012 Aug 9.


PMID- 23472789
OWN - NLM
STAT- MEDLINE
DCOM- 20130919
LR  - 20130311
IS  - 1878-7487 (Electronic)
IS  - 1752-928X (Linking)
VI  - 20
IP  - 3
DP  - 2013 Apr
TI  - Use of role play in undergraduate teaching of ethics - an experience.
PG  - 136-8
LID - 10.1016/j.jflm.2012.06.010 [doi]
LID - S1752-928X(12)00149-7 [pii]
AB  - Lecture is the traditional way of teaching adopted in our routine. Learning about
      medical ethics used to be done by lecture. All of us felt that learning some
      aspects of ethics requires a deeper understanding of the topics especially those 
      areas involving feelings and emotions. So the role play method was chosen. We
      taught the topics consent and euthanasia by both the didactic method and by role 
      play to the students of second year MBBS during the period June-July 2012 and
      then we compared the results. We have tried to evaluate role play vis-a vis
      lecture by analyzing the feedback from the students. The affective component
      analysis requires a different method of teaching and assessment as shown by our
      experience.
CI  - Copyright (c) 2012 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All
      rights reserved.
FAU - Noone, Padmini Hannah
AU  - Noone PH
AD  - Department of Forensic Medicine, Vydehi Institute of Medical Sciences and
      Research Centre, Bangalore 560066, India. padmini.noone@gmail.com
FAU - Raj Sharma, Sudhamshu
AU  - Raj Sharma S
FAU - Khan, Fairoz
AU  - Khan F
FAU - Raviraj, K G
AU  - Raviraj KG
FAU - Shobhana, S S
AU  - Shobhana SS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20120706
PL  - England
TA  - J Forensic Leg Med
JT  - Journal of forensic and legal medicine
JID - 101300022
SB  - IM
MH  - *Education, Medical, Undergraduate
MH  - Ethics, Medical/*education
MH  - Euthanasia/ethics
MH  - Feedback
MH  - Humans
MH  - India
MH  - Informed Consent/ethics
MH  - *Role Playing
MH  - Students, Medical
EDAT- 2013/03/12 06:00
MHDA- 2013/09/21 06:00
CRDT- 2013/03/12 06:00
PHST- 2012/02/25 00:00 [received]
PHST- 2012/05/16 00:00 [revised]
PHST- 2012/06/17 00:00 [accepted]
PHST- 2013/03/12 06:00 [entrez]
PHST- 2013/03/12 06:00 [pubmed]
PHST- 2013/09/21 06:00 [medline]
AID - S1752-928X(12)00149-7 [pii]
AID - 10.1016/j.jflm.2012.06.010 [doi]
PST - ppublish
SO  - J Forensic Leg Med. 2013 Apr;20(3):136-8. doi: 10.1016/j.jflm.2012.06.010. Epub
      2012 Jul 6.


PMID- 23461099
OWN - NLM
STAT- MEDLINE
DCOM- 20130725
LR  - 20130306
IS  - 1542-3050 (Print)
IS  - 1542-3050 (Linking)
VI  - 66
IP  - 3-4
DP  - 2012 Fall-Winter
TI  - Conditions for religious discourse in secularized ethical health care
      deliberation.
PG  - 6
AB  - Religious discourse is no longer self-evident in professional health care ethical
      deliberation in the North Atlantic cultural sphere. However, in a world of
      pluralism, care professionals still seek substantive views of good care.
      Religious and non-religious beliefs should not be excluded from ethical
      deliberation. They offer patients and professionals a helpful language for
      expressing values and beliefs. Chaplains have a role to play as allies in
      sense-making processes and resourcing care.
FAU - van Nistelrooy, Inge
AU  - van Nistelrooy I
AD  - Tilburg School of Humanities, Tilburg University, Netherlands.
      A.A.M.vanNistelrooij@uvt.nl
FAU - Vosman, Frans
AU  - Vosman F
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pastoral Care Counsel
JT  - The journal of pastoral care & counseling : JPCC
JID - 101144384
MH  - Attitude to Health
MH  - Cultural Characteristics
MH  - Cultural Diversity
MH  - Humans
MH  - Netherlands
MH  - Pastoral Care/*ethics/methods
MH  - *Professional Competence
MH  - Professional-Patient Relations/*ethics
MH  - *Religion and Medicine
MH  - *Secularism
MH  - *Spirituality
EDAT- 2013/03/07 06:00
MHDA- 2013/07/26 06:00
CRDT- 2013/03/07 06:00
PHST- 2013/03/07 06:00 [entrez]
PHST- 2013/03/07 06:00 [pubmed]
PHST- 2013/07/26 06:00 [medline]
PST - ppublish
SO  - J Pastoral Care Counsel. 2012 Fall-Winter;66(3-4):6.


PMID- 23461095
OWN - NLM
STAT- MEDLINE
DCOM- 20130725
LR  - 20130306
IS  - 1542-3050 (Print)
IS  - 1542-3050 (Linking)
VI  - 66
IP  - 3-4
DP  - 2012 Fall-Winter
TI  - The 'methodic' exploration of the ethical and pastoral dimension in interaction: 
      the cycle of encounter.
PG  - 2
AB  - Social competence can be understood as the capacity to interact with each other. 
      As such, it is the acquisition and optimization of an interior attitude that
      transcends technique; it is a way of loving and doing justice to one another. A
      scheme is presented to explore the ethical and spiritual dimensions of the
      pastoral counseling process. Ethics is both an objective discipline and a
      relationship. Relationships are built during qualitative encounters that build
      respect and construct religious meanings. All encounters share this process. This
      article explores the logic of ethical dynamics with particular focus on pastoral 
      counseling encounters.
FAU - Riemslagh, Marina
AU  - Riemslagh M
AD  - Faculty of Theology, Training and Coaching, Catholic University of Leuven-Voluit,
      Leuven, Bornem, Belgium. Marina.Riemslagh@gmail.com
FAU - Cuvelier, Ferdinand
AU  - Cuvelier F
FAU - Burggraeve, Roger
AU  - Burggraeve R
FAU - Corveleyn, Jozef
AU  - Corveleyn J
FAU - Liegeois, Axel
AU  - Liegeois A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pastoral Care Counsel
JT  - The journal of pastoral care & counseling : JPCC
JID - 101144384
MH  - Altruism
MH  - Chaplaincy Service, Hospital/ethics/methods
MH  - Clergy/ethics/methods
MH  - Humans
MH  - *Interpersonal Relations
MH  - Pastoral Care/*ethics/*methods
MH  - Professional Role
MH  - *Professional-Patient Relations
MH  - *Spirituality
EDAT- 2013/03/07 06:00
MHDA- 2013/07/26 06:00
CRDT- 2013/03/07 06:00
PHST- 2013/03/07 06:00 [entrez]
PHST- 2013/03/07 06:00 [pubmed]
PHST- 2013/07/26 06:00 [medline]
PST - ppublish
SO  - J Pastoral Care Counsel. 2012 Fall-Winter;66(3-4):2.


PMID- 23459767
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 0303-3295 (Print)
IS  - 0303-3295 (Linking)
VI  - 28
IP  - 2
DP  - 2012 Jul
TI  - [Competence in biocentric ethics.]
PG  - 123-127
AB  - ResumenEste articulo explora el origen y la conceptualizacion de la bioetica en
      tanto etica biocentrica, definida por el pionero Fritz Jahr como un imperativo
      hipotetico que llama a respetar la vida en todas sus formas. Tras describirla
      como proceso social, procedimiento tecnico y producto academico, se enumeran y
      comentan algunas competencias que debieran presidir el empleo del discurso
      bioetico en cualquier punto del complejo social "investigacion medica": miembros 
      de comites de etica de investigacion, investigadores, empresarios,
      administradores. Cada uno de estos grupos, en su "cultura epistemica" propia,
      define y explicita los principios basicos en tanto expresion de valores y leyes
      generales.
FAU - Stepke, Fernando Lolas
AU  - Stepke FL
AD  - Profesor Titular, Departamento de Psiquiatria, Hospital Clinico y Director,
      Centro Interdisciplinario de Estudios en Bioetica, Universidad de Chile.
LA  - fre
GR  - R25 TW006056/TW/FIC NIH HHS/United States
PT  - Journal Article
TT  - Competencias en etica biocentrica: Un fundamento para la investigacion medica.
DEP - 20120413
PL  - Uruguay
TA  - Rev Med Urug (Montev)
JT  - La Revista medica del Uruguay
JID - 7502186
PMC - PMC3583385
MID - NIHMS401560
OTO - NOTNLM
OT  - BIOETHICS
OT  - BIOMEDICAL RESEARCH
OT  - BIOETICA
OT  - INVESTIGACION BIOMEDICA
EDAT- 2013/03/06 06:00
MHDA- 2013/03/06 06:01
CRDT- 2013/03/06 06:00
PHST- 2013/03/06 06:00 [entrez]
PHST- 2013/03/06 06:00 [pubmed]
PHST- 2013/03/06 06:01 [medline]
PST - ppublish
SO  - Rev Med Urug (Montev). 2012 Jul;28(2):123-127. Epub 2012 Apr 13.


PMID- 23459337
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1875-6867 (Print)
IS  - 1875-6859 (Linking)
VI  - 9
IP  - 2
DP  - 2012 Jun 1
TI  - The potential influence of masculine identity on health-improving behavior in
      midlife and older African American men.
PG  - 79-88
AB  - OBJECTIVE: To gain a greater understanding of masculinity and its potential
      influence on health-improving behavior in midlife and older African American (AA)
      men. METHODS: Forty-nine AA men aged 45-88 years completed in-depth interviews to
      ascertain their perspectives on masculinity, how masculine identity in this
      population might be influenced by age and physical activity level, or how it
      might impact health. Taped interviews were transcribed and organized for analysis
      with common themes identified by multiple researchers. RESULTS: Most often cited 
      attributes of someone considered "manly" included a leader of a family/household,
      provider, strong work ethic, and masculine physique. Terms such as responsible,
      principled, and man of character also described the typical man. Potential
      negative and positive influences of manhood on health included avoiding health
      care appointments and being a good example to children/others, respectively.
      Themes associated with age-related changes in manhood were acceptance and being
      more health conscious. Elements associated with how manhood was influenced by AA 
      race included stress and perseverance. CONCLUSIONS: Midlife and older AA men in
      this study primarily expressed views of masculinity that fit the traditional
      perception of manhood. However, the attributes revealed, such as family provider,
      responsibility, self-reliance, and perseverance, were viewed as having potential 
      for both negative and positive impacts on health and health-improving behaviors. 
      It will be essential to integrate these prevalent attributes of masculine
      identity into health promotion interventions such that they facilitate positive
      behavior change while not competing with gender role norms among this vulnerable 
      group of men.
FAU - Hooker, Steven P
AU  - Hooker SP
FAU - Wilcox, Sara
AU  - Wilcox S
FAU - Burroughs, Ericka L
AU  - Burroughs EL
FAU - Rheaume, Carol E
AU  - Rheaume CE
FAU - Courtenay, Will
AU  - Courtenay W
LA  - eng
GR  - R21 AG028674/AG/NIA NIH HHS/United States
GR  - R21 AG028674-01/AG/NIA NIH HHS/United States
PT  - Journal Article
PL  - Singapore
TA  - J Mens Health
JT  - Journal of men's health
JID - 101471801
PMC - PMC3580856
MID - NIHMS363501
OTO - NOTNLM
OT  - Aging
OT  - Black males
OT  - Health promotion
OT  - Masculinity
OT  - Qualitative research
EDAT- 2013/03/06 06:00
MHDA- 2013/03/06 06:01
CRDT- 2013/03/06 06:00
PHST- 2013/03/06 06:00 [entrez]
PHST- 2013/03/06 06:00 [pubmed]
PHST- 2013/03/06 06:01 [medline]
AID - 10.1016/j.jomh.2012.02.001 [doi]
PST - ppublish
SO  - J Mens Health. 2012 Jun 1;9(2):79-88. doi: 10.1016/j.jomh.2012.02.001.


PMID- 23451317
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130304
LR  - 20220318
IS  - 1949-8349 (Print)
IS  - 1949-8357 (Linking)
VI  - 4
IP  - 1
DP  - 2012 Mar
TI  - Education in professionalism: results from a survey of pediatric residency
      program directors.
PG  - 101-5
LID - 10.4300/JGME-D-11-00110.1 [doi]
AB  - BACKGROUND: The Accreditation Council for Graduate Medical Education (ACGME)
      requires pediatric residency programs to teach professionalism but does not
      provide concrete guidance for fulfilling these requirements. Individual programs,
      therefore, adopt their own methods for teaching and evaluating professionalism,
      and published research demonstrating how to satisfy the ACGME professionalism
      requirement is lacking. METHODS: We surveyed pediatric residency program
      directors in 2008 to explore the establishment of expectations for professional
      conduct, the educational experiences used to foster learning in professionalism, 
      and the evaluation of professionalism. RESULTS: Surveys were completed by 96 of
      189 program directors (51%). A majority reported that new interns attend a
      session during which expectations for professionalism are conveyed, either
      verbally (93%) or in writing (65%). However, most program directors reported that
      "None or Few" of their residents engaged in multiple educational experiences that
      could foster learning in professionalism. Despite the identification of
      professionalism as a core competency, a minority (28%) of programs had a written 
      curriculum in ethics or professionalism. When evaluating professionalism, the
      most frequently used assessment strategies were rated as "very useful" by only a 
      modest proportion (26%-54%) of respondents. CONCLUSIONS: Few programs have
      written curricula in professionalism, and opportunities for experiential learning
      in professionalism may be limited. In addition, program directors express only
      moderate satisfaction with current strategies for evaluating professionalism that
      were available through 2008.
FAU - Kesselheim, Jennifer C
AU  - Kesselheim JC
FAU - Sectish, Theodore C
AU  - Sectish TC
FAU - Joffe, Steven
AU  - Joffe S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Grad Med Educ
JT  - Journal of graduate medical education
JID - 101521733
PMC - PMC3312515
EDAT- 2013/03/02 06:00
MHDA- 2013/03/02 06:01
CRDT- 2013/03/02 06:00
PHST- 2011/05/13 00:00 [received]
PHST- 2011/09/12 00:00 [revised]
PHST- 2011/09/12 00:00 [accepted]
PHST- 2013/03/02 06:00 [entrez]
PHST- 2013/03/02 06:00 [pubmed]
PHST- 2013/03/02 06:01 [medline]
AID - 10.4300/JGME-D-11-00110.1 [doi]
AID - JGME-D-11-00110 [pii]
PST - ppublish
SO  - J Grad Med Educ. 2012 Mar;4(1):101-5. doi: 10.4300/JGME-D-11-00110.1.


PMID- 23450856
OWN - NLM
STAT- MEDLINE
DCOM- 20130501
LR  - 20211021
IS  - 0008-5286 (Print)
IS  - 0008-5286 (Linking)
VI  - 53
IP  - 9
DP  - 2012 Sep
TI  - An ethicist's commentary on euthanasia for tooth problem.
PG  - 922
FAU - Rollin, Bernard E
AU  - Rollin BE
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Canada
TA  - Can Vet J
JT  - The Canadian veterinary journal = La revue veterinaire canadienne
JID - 0004653
SB  - IM
MH  - Animal Welfare
MH  - Animals
MH  - Costs and Cost Analysis
MH  - Dogs
MH  - *Ethics, Professional
MH  - Euthanasia, Animal/*ethics
MH  - Female
MH  - Halitosis/diagnosis/surgery/*veterinary
MH  - Surgery, Veterinary/*economics
MH  - Tooth Fractures/diagnosis/surgery/*veterinary
MH  - Veterinary Medicine/ethics
PMC - PMC3418777
EDAT- 2013/03/02 06:00
MHDA- 2013/05/02 06:00
CRDT- 2013/03/02 06:00
PHST- 2013/03/02 06:00 [entrez]
PHST- 2013/03/02 06:00 [pubmed]
PHST- 2013/05/02 06:00 [medline]
PST - ppublish
SO  - Can Vet J. 2012 Sep;53(9):922.


PMID- 23450235
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130412
LR  - 20211021
IS  - 0970-0358 (Print)
IS  - 0970-0358 (Linking)
VI  - 45
IP  - 3
DP  - 2012 Sep
TI  - Ethical and legal issues in aesthetic surgery.
PG  - 547-9
LID - 10.4103/0970-0358.105973 [doi]
AB  - Rapid growth and expansion of plastic surgery in general and aesthetic surgery in
      particular in the past decade has brought in its wake some confusions
      particularly raising questions for the surgeons conduct towards his colleagues
      and the patients in the light of ethical requirements. Some thoughts from eminent
      thinkers form a backdrop to consideration of theories of medical ethics. In this 
      article raging and continuous debates on these subjects have been avoided to
      maintain the momentum. Apart from the western thoughts, directions from our old
      scriptures on ethical conduct have been included to accommodate prevelant Indian 
      practices. The confusion created by specialists advertising their abilities
      directly to the lay public following removal of ethical bars by the American
      Courts as also latitudes allowed by the General Medical Council of Great Britain 
      have been discussed. The medical fraternity however has its reservations.
      Unnecessary skirmishes with the law arose in cosmetic surgery from the freedom
      exercised by the police to file criminal proceedings against attending doctors in
      the event of a patient's death with or without any evidence of wrong doing. This 
      has now been curtailed in the judgement of the Supreme Court of India[1] where
      norms have been laid down for such prosecution. This has helped doctors to
      function without fear of harassment. An effort has been made to state a simple
      day-to-day routine for an ethical doctor-patient relationship.
FAU - Gupta, Suresh
AU  - Gupta S
AD  - Emeritus Consultant in Plastic Surgery and Head of Aesthetic Surgery Unit,
      Department of Plastic Surgery Sir Gangaram Hospital, New Delhi, India.
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Indian J Plast Surg
JT  - Indian journal of plastic surgery : official publication of the Association of
      Plastic Surgeons of India
JID - 8405356
PMC - PMC3580358
OTO - NOTNLM
OT  - Aesthetic surgery
OT  - legal
OT  - medical ethics
EDAT- 2013/03/02 06:00
MHDA- 2013/03/02 06:01
CRDT- 2013/03/02 06:00
PHST- 2013/03/02 06:00 [entrez]
PHST- 2013/03/02 06:00 [pubmed]
PHST- 2013/03/02 06:01 [medline]
AID - 10.4103/0970-0358.105973 [doi]
AID - IJPS-45-547 [pii]
PST - ppublish
SO  - Indian J Plast Surg. 2012 Sep;45(3):547-9. doi: 10.4103/0970-0358.105973.


PMID- 23450040
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130304
LR  - 20211021
IS  - 0738-6729 (Print)
IS  - 0738-6729 (Linking)
VI  - 35
IP  - 2
DP  - 2012 Fall
TI  - Joseph v. Brady: synthesis reunites what analysis has divided.
PG  - 197-208
AB  - Joseph V. Brady (1922-2011) created behavior-analytic neuroscience and the
      analytic framework for understanding how the external and internal
      neurobiological environments and mechanisms interact. Brady's approach offered
      synthesis as well as analysis. He embraced Findley's approach to constructing
      multioperant behavioral repertoires that found their way into designing
      environments for astronauts as well as studying drug effects on human social
      behavior in microenvironments. Brady created translational neurobehavioral
      science before such a concept existed. One of his most lasting contributions was 
      developing a framework for ethical decision making to protect the rights of the
      people who participate in scientific research.
FAU - Thompson, Travis
AU  - Thompson T
AD  - University of Minnesota.
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Behav Anal
JT  - The Behavior analyst
JID - 8303067
PMC - PMC3501422
OTO - NOTNLM
OT  - Joseph V. Brady
OT  - interdisciplinary
OT  - neuroscience
OT  - research ethics
OT  - space research
EDAT- 2013/03/02 06:00
MHDA- 2013/03/02 06:01
CRDT- 2013/03/02 06:00
PHST- 2013/03/02 06:00 [entrez]
PHST- 2013/03/02 06:00 [pubmed]
PHST- 2013/03/02 06:01 [medline]
AID - 10.1007/BF03392278 [doi]
PST - ppublish
SO  - Behav Anal. 2012 Fall;35(2):197-208. doi: 10.1007/BF03392278.


PMID- 23449238
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130304
LR  - 20220318
IS  - 1558-9447 (Print)
IS  - 1558-9447 (Linking)
VI  - 7
IP  - 1
DP  - 2012 Mar
TI  - A systematic review of peer review for scientific manuscripts.
PG  - 37-44
LID - 10.1007/s11552-012-9392-6 [doi]
AB  - BACKGROUND: The usefulness of peer review has been expressed as a method to
      improve the quality of published work. However, there has been a lack of
      systematic reviews to date to highlight the essential themes of the peer-review
      process. METHODS: We performed a search of the English language literature
      published prior to October 2011 using PubMed to identify articles regarding peer 
      review. Inclusion and exclusion criteria were developed a priori. Data were
      extracted and then analyzed for the prevalence of peer-review themes contained
      within the literature. RESULTS: Of the 941 articles found during our original
      literature search, 37 were selected for review. The majority were
      commentary/editorial articles. The themes in our search included the structure
      and process of the peer-review system, the criteria for papers, ethics, and the
      different forms of the peer-review process. CONCLUSIONS: The criteria for
      submission will vary, but our systematic review provides a comprehensive overview
      of what reviewers expect from authors. Our systematic review also highlighted
      ethical considerations for both authors and reviewers during the peer-review
      process. Although the topic of peer review is expansive and its process may vary 
      from journal to journal, the understanding of the themes outlined in this paper
      will help authors recognize how to write a more successful paper. Also, more
      research must be carried out to establish the efficacy of the different styles of
      peer review, and it would be presumptuous to draw conclusions until further
      research is established.
FAU - Larson, Bradley P
AU  - Larson BP
AD  - Section of Plastic Surgery, Department of Surgery, The University of Michigan
      Health System, 2130 Taubman Center, SPC 5340, 1500 E. Medical Center Drive, Ann
      Arbor, MI 48109-5340 USA.
FAU - Chung, Kevin C
AU  - Chung KC
LA  - eng
GR  - K24 AR053120/AR/NIAMS NIH HHS/United States
GR  - R01 AR047328/AR/NIAMS NIH HHS/United States
GR  - R01 AR062066/AR/NIAMS NIH HHS/United States
PT  - Journal Article
DEP - 20120201
PL  - United States
TA  - Hand (N Y)
JT  - Hand (New York, N.Y.)
JID - 101264149
PMC - PMC3280371
OTO - NOTNLM
OT  - Ethics
OT  - Peer review
OT  - Research methods
OT  - Systematic review
EDAT- 2013/03/02 06:00
MHDA- 2013/03/02 06:01
CRDT- 2013/03/02 06:00
PHST- 2013/03/02 06:00 [entrez]
PHST- 2013/03/02 06:00 [pubmed]
PHST- 2013/03/02 06:01 [medline]
AID - 10.1007/s11552-012-9392-6 [doi]
AID - 9392 [pii]
PST - ppublish
SO  - Hand (N Y). 2012 Mar;7(1):37-44. doi: 10.1007/s11552-012-9392-6. Epub 2012 Feb 1.


PMID- 23449088
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130304
LR  - 20211021
IS  - 1863-2548 (Electronic)
IS  - 1863-2521 (Linking)
VI  - 6
IP  - 1
DP  - 2012 Mar
TI  - Utility of magnetic resonance imaging (MRI) after closed reduction of
      developmental dysplasia of the hip.
PG  - 13-20
LID - 10.1007/s11832-012-0382-6 [doi]
AB  - PURPOSE: Magnetic resonance imaging (MRI) has been successfully used in the
      determination of the adequacy of the surgical reduction of congenitally
      dislocated hips in children. We present the results of a prospective series of
      patients treated conservatively. MRI was performed in all hips after positioning 
      was deemed adequate on radiographs after spica cast application. The goal of this
      study was to evaluate the usefulness of MRI in this indication. METHODS: After
      the study was approved by our local ethics committee, 31 patients for a total of 
      36 dislocated hips were included. After the traction period, hip testing was
      performed and a hip spica cast was applied under general anaesthesia. All
      children had MRI within 1 week of reduction, without the need for contention or
      general anaesthesia. Hip reduction was assessed on axial and coronal MRI images. 
      RESULTS: The concentric reduction of the hip was confirmed in 30 cases out of 36.
      In three cases, the dislocation was retrospectively suspected on radiographs and 
      then confirmed. In the three remaining cases, hip dislocation was only diagnosed 
      on MRI. CONCLUSIONS: MRI screening of congenitally dislocated hips after
      reduction procedures is a safe and reliable procedure to assess the concentric
      reduction of the hip. Even in doubtful cases, MRI detected persistent hip
      dislocations and was conducive to iterative reduction and satisfactory outcome
      and result.
FAU - Bachy, Manon
AU  - Bachy M
AD  - Department of Pediatric Orthopaedics, Universite Pierre et Marie Curie Paris6,
      Armand Trousseau Hospital, 26 avenue du Dr. Arnold Netter, 75571 Paris Cedex 12, 
      France.
FAU - Thevenin-Lemoine, Camille
AU  - Thevenin-Lemoine C
FAU - Rogier, Amelie
AU  - Rogier A
FAU - Mary, Pierre
AU  - Mary P
FAU - Ducou Le Pointe, Hubert
AU  - Ducou Le Pointe H
FAU - Vialle, Raphael
AU  - Vialle R
LA  - eng
PT  - Journal Article
DEP - 20120111
PL  - England
TA  - J Child Orthop
JT  - Journal of children's orthopaedics
JID - 101313582
PMC - PMC3303019
OTO - NOTNLM
OT  - Congenital dislocation of the hip
OT  - Conservative treatment
OT  - Hip spica cast
OT  - MRI
OT  - Traction
EDAT- 2013/03/02 06:00
MHDA- 2013/03/02 06:01
CRDT- 2013/03/02 06:00
PHST- 2011/06/29 00:00 [received]
PHST- 2012/01/03 00:00 [accepted]
PHST- 2013/03/02 06:00 [entrez]
PHST- 2013/03/02 06:00 [pubmed]
PHST- 2013/03/02 06:01 [medline]
AID - 10.1007/s11832-012-0382-6 [doi]
AID - 382 [pii]
PST - ppublish
SO  - J Child Orthop. 2012 Mar;6(1):13-20. doi: 10.1007/s11832-012-0382-6. Epub 2012
      Jan 11.


PMID- 23447900
OWN - NLM
STAT- MEDLINE
DCOM- 20130409
LR  - 20170203
IS  - 0723-1393 (Print)
IS  - 0723-1393 (Linking)
VI  - 31
IP  - 4
DP  - 2012 Dec
TI  - Experimental course of bioethics upon the bioethics core curriculum of UNESCO:
      methodoloy and result of investigation.
PG  - 495-511
AB  - In October 2005 the General Conference of UNESCO adopted the Universal
      Declaration on Bioethics and Human Rights. The aim of this Declaration was to
      assist in the realization ofprinciples and support the thorough understanding of 
      the consequences of the ethics of scientific and technical progress, especially
      for youth. In 2008, the Division of Ethics of Science and Technology Sector for
      Social and Human Sciences of UNESCO worked out an Educational Program (Bioethics 
      Core Curriculum). On November 23, 2010 a Memorandum was signed between UNESCO and
      the Yerevan State Medical University after M. Heratsi. The Memorandum was aimed
      to test the Bioethics Core Curriculum of UNESCO. In this article we will analyze 
      the aims and goals of studying the course, as well as disputable shortcomings of 
      the Program, make recommendations for the improvement of the course of bioethics,
      and highlight the positive aspects of this Educational Program.
FAU - Davtyan, S
AU  - Davtyan S
AD  - Yerevan State Medical University after M. Heratsi, 2011 Armenian Unit of
      International Network of UNESCO Chair in Bioethics. 0025 Armenia, Yerevan, Koryun
      2. andro099@yahoo.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Law
JT  - Medicine and law
JID - 8218185
SB  - IM
MH  - Armenia
MH  - Bioethics/*education
MH  - *Curriculum
MH  - Education, Medical, Undergraduate
MH  - Humans
MH  - Schools, Medical
MH  - United Nations
EDAT- 2013/03/02 06:00
MHDA- 2013/04/10 06:00
CRDT- 2013/03/02 06:00
PHST- 2013/03/02 06:00 [entrez]
PHST- 2013/03/02 06:00 [pubmed]
PHST- 2013/04/10 06:00 [medline]
PST - ppublish
SO  - Med Law. 2012 Dec;31(4):495-511.


PMID- 23446320
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130301
LR  - 20130228
IS  - 1538-3679 (Electronic)
IS  - 0003-9926 (Linking)
VI  - 172
IP  - 8
DP  - 2012 Apr 23
TI  - Cardiac implantable electronic devices: prevention starts from ethics-reply.
PG  - 670-2
LID - 10.1001/archinternmed.2012.839 [doi]
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Arch Intern Med
JT  - Archives of internal medicine
JID - 0372440
EDAT- 2013/03/01 06:00
MHDA- 2013/03/01 06:01
CRDT- 2013/03/01 06:00
PHST- 2013/03/01 06:00 [entrez]
PHST- 2013/03/01 06:00 [pubmed]
PHST- 2013/03/01 06:01 [medline]
AID - 1135421 [pii]
AID - 10.1001/archinternmed.2012.839 [doi]
PST - ppublish
SO  - Arch Intern Med. 2012 Apr 23;172(8):670-2. doi: 10.1001/archinternmed.2012.839.


PMID- 23445703
OWN - NLM
STAT- MEDLINE
DCOM- 20130709
LR  - 20211021
IS  - 1916-9736 (Print)
IS  - 1916-9736 (Linking)
VI  - 5
IP  - 2
DP  - 2012 Dec 26
TI  - Sensationalising the female pudenda: an examination of public communication of
      aesthetic genital surgery.
PG  - 153-65
LID - 10.5539/gjhs.v5n2p153 [doi]
AB  - We live in a society where beauty and sensations are important. Advances in
      medical technologies have brought on waves of new notions of beauty where
      commercial interests both in the media and the health industry spurred by
      fashion, advertising and celebrity promotion have tended to popularise body
      modifications and enhancements. In recent times, through offerings on cable
      television channels and glossy consumer magazines, medical procedures hitherto
      only in the precincts of medical schools, gyneacological clinics and medical
      journals have now pervaded the population. More seriously, on the Internet
      particularly, medical experts now offer services and graphic details of
      labiaplasty, clitoral hood reduction or enhancement, vaginal rejuvenation, etc.
      Here, we examine the public communication of the phenomenon of aesthetic genital 
      surgery and interrogate thus; is it decent, honest, balanced and ethical? Relying
      on textual analysis, personal observation and literature review for data
      gathering, we observe that besides tending to commercialise and medicalise the
      female genitalia, a coalescence of medical, advertising and fashion interests as 
      played out in the media sensationalises the benign science of plastic surgery and
      robs it of its truthfulness, genuineness, and purposefulness. The conclusion is
      that in Africa, where the effect of the development crises is telling, the hype
      surrounding cosmetic or aesthetic genital surgery is a damaging distraction
      particularly when the continent is waging a battle against female genital
      mutilation. The recommendations are that media and medical regulatory bodies
      should impress it upon media and medical industry operators that glaring
      commercial promotions of cosmetic genital surgery in the public media be checked,
      and that such communication should bear equal weight of facts related to risks,
      short comings, complications, and threats; in physical, social, and psychological
      terms.
FAU - Ashong, Ashong C
AU  - Ashong AC
AD  - Department of Communication Arts, University of Uyo, Uyo, Akwa-Ibom, Nigeria.
FAU - Batta, Herbert E
AU  - Batta HE
LA  - eng
PT  - Journal Article
DEP - 20121226
PL  - Canada
TA  - Glob J Health Sci
JT  - Global journal of health science
JID - 101519495
SB  - IM
MH  - Africa
MH  - *Beauty
MH  - Communications Media
MH  - Elective Surgical Procedures/*methods/*psychology
MH  - Female
MH  - Genitalia, Female/*surgery
MH  - Humans
MH  - Internet
MH  - Surgery, Plastic/*methods/*psychology
PMC - PMC4776801
EDAT- 2013/03/01 06:00
MHDA- 2013/07/10 06:00
CRDT- 2013/03/01 06:00
PHST- 2012/12/08 00:00 [received]
PHST- 2012/12/22 00:00 [accepted]
PHST- 2013/03/01 06:00 [entrez]
PHST- 2013/03/01 06:00 [pubmed]
PHST- 2013/07/10 06:00 [medline]
AID - 10.5539/gjhs.v5n2p153 [doi]
PST - epublish
SO  - Glob J Health Sci. 2012 Dec 26;5(2):153-65. doi: 10.5539/gjhs.v5n2p153.


PMID- 23444539
OWN - NLM
STAT- MEDLINE
DCOM- 20130527
LR  - 20130228
IS  - 1118-4841 (Print)
IS  - 1118-4841 (Linking)
VI  - 16
IP  - 4
DP  - 2012 Dec
TI  - Management of infertility in HIV infected couples: a review.
PG  - 13-20
AB  - The HIV epidemic has continued to grow and remains a major challenge to mankind. 
      In the past, ethical considerations about the resulting child and risks of
      sexual, vertical and nosocomial transmission of HIV prevented practitioners from 
      offering fertility services to people living with HIV. In recent times however,
      the use of highly active antiretroviral therapy (HAART), has not only improved
      the life expectancy and quality of life of those infected but also reduced the
      risk of HIV transmission. The need for fertility services in the HIV-positive
      population has thus increased and may be employed for management of infertility
      and protection from transmission or acquisition of HIV infection. As such,
      preconception counseling, sexual health and fertility screening have become
      routine in the management of HIV-positive couples. The option of care include
      adoption, self insemination with husband sperm, embryo donation from couples who 
      have been verified to be HIV negative, insemination with donor sperm, timed
      unprotected intercourse (TUI) and sperm washing combined with intrauterine
      insemination (IUI) and assisted reproductive technology (ART) including in-vitro 
      fertilization (IVF) or intracytoplasmic sperm injection (ICSI). Access to these
      fertility services by HIV-positive clients should be facilitated as part of
      efforts to promote their reproductive health and rights.
FAU - Agboghoroma, Chris O
AU  - Agboghoroma CO
AD  - Department of Obstetrics & Gynaecology, National Hospital Abuja.
      agboschris@yahoo.com
FAU - Giwa-Osagie, Osato F
AU  - Giwa-Osagie OF
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Nigeria
TA  - Afr J Reprod Health
JT  - African journal of reproductive health
JID - 9712263
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Africa/epidemiology
MH  - Antiretroviral Therapy, Highly Active/*methods
MH  - Comorbidity
MH  - Disease Management
MH  - Epidemics/*statistics & numerical data
MH  - Female
MH  - *HIV Infections/drug therapy/epidemiology/psychology/transmission
MH  - Humans
MH  - Infectious Disease Transmission, Vertical/*prevention & control
MH  - *Infertility/epidemiology/etiology/therapy
MH  - Life Expectancy
MH  - Male
MH  - Quality of Life
MH  - Reproductive Health
MH  - *Reproductive Techniques, Assisted/classification/statistics & numerical data
EDAT- 2013/03/01 06:00
MHDA- 2013/05/29 06:00
CRDT- 2013/03/01 06:00
PHST- 2013/03/01 06:00 [entrez]
PHST- 2013/03/01 06:00 [pubmed]
PHST- 2013/05/29 06:00 [medline]
PST - ppublish
SO  - Afr J Reprod Health. 2012 Dec;16(4):13-20.


PMID- 26858858
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160209
LR  - 20220311
IS  - 2155-1790 (Print)
IS  - 2155-1790 (Linking)
VI  - 4
IP  - 3
DP  - 2013 Mar
TI  - Human Decidua-Derived Mesenchymal Cells Are a Promising Source for the Generation
      and Cell Banking of Human Induced Pluripotent Stem Cells.
PG  - 125-47
LID - 10.3727/215517912X658918 [doi]
AB  - Placental tissue is a biomaterial with remarkable potential for use in
      regenerative medicine. It has a three-layer structure derived from the fetus
      (amnion and chorion) and the mother (decidua), and it contains huge numbers of
      cells. Moreover, placental tissue can be collected without any physical danger to
      the donor and can be matched with a variety of HLA types. The decidua-derived
      mesenchymal cells (DMCs) are highly proliferative fibroblast-like cells that
      express a similar pattern of CD antigens as bone marrow-derived mesenchymal cells
      (BM-MSCs). Here we demonstrated that induced pluripotent stem (iPS) cells could
      be efficiently generated from DMCs by retroviral transfer of reprogramming factor
      genes. DMC-hiPS cells showed equivalent characteristics to human embryonic stem
      cells (hESCs) in colony morphology, global gene expression profile (including
      human pluripotent stem cell markers), DNA methylation status of the OCT3/4 and
      NANOG promoters, and ability to differentiate into components of the three germ
      layers in vitro and in vivo. The RNA expression of XIST and the methylation
      status of its promoter region suggested that DMC-iPSCs, when maintained
      undifferentiated and pluripotent, had three distinct states: (1) complete
      X-chromosome reactivation, (2) one inactive X-chromosome, or (3) an epigenetic
      aberration. Because DMCs are derived from the maternal portion of the placenta,
      they can be collected with the full consent of the adult donor and have
      considerable ethical advantages for cell banking and the subsequent generation of
      human iPS cells for regenerative applications.
FAU - Shofuda, Tomoko
AU  - Shofuda T
AD  - Division of Stem Cell Research, Institute for Clinical Research, Osaka National
      Hospital, National Hospital Organization , Chuo-ku, Osaka , Japan.
FAU - Kanematsu, Daisuke
AU  - Kanematsu D
AD  - dagger Division of Regenerative Medicine, Institute for Clinical Research, Osaka 
      National Hospital, National Hospital Organization , Osaka , Japan.
FAU - Fukusumi, Hayato
AU  - Fukusumi H
AD  - dagger Division of Regenerative Medicine, Institute for Clinical Research, Osaka 
      National Hospital, National Hospital Organization , Osaka , Japan.
FAU - Yamamoto, Atsuyo
AU  - Yamamoto A
AD  - Division of Stem Cell Research, Institute for Clinical Research, Osaka National
      Hospital, National Hospital Organization , Chuo-ku, Osaka , Japan.
FAU - Bamba, Yohei
AU  - Bamba Y
AD  - double dagger Department of Physiology, Keio University School of Medicine ,
      Shinjuku-ku, Tokyo , Japan.
FAU - Yoshitatsu, Sumiko
AU  - Yoshitatsu S
AD  - section sign Department of Plastic Surgery, Osaka National Hospital, National
      Hospital Organization , Osaka , Japan.
FAU - Suemizu, Hiroshi
AU  - Suemizu H
AD  - paragraph sign Biomedical Research Department, Central Institute for Experimental
      Animals , Kawasaki-ku, Kawasaki , Japan.
FAU - Nakamura, Masato
AU  - Nakamura M
AD  - paragraph signBiomedical Research Department, Central Institute for Experimental 
      Animals, Kawasaki-ku, Kawasaki, Japan; #Department of Pathology and Regenerative 
      Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
FAU - Sugimoto, Yoshikazu
AU  - Sugimoto Y
AD  - * Division of Chemotherapy, Faculty of Pharmacy, Keio University , Minato-ku,
      Tokyo , Japan.
FAU - Furue, Miho Kusuda
AU  - Furue MK
AD  - daggerdagger Laboratory of Stem Cell Cultures, Laboratory of Cell Cultures,
      Department of Disease Bioresources Research, National Institute of Biomedical
      Innovation , Ibaraki, Osaka , Japan.
FAU - Kohara, Arihiro
AU  - Kohara A
AD  - double daggerdouble dagger JCRB Cell Bank, Laboratory of Cell Cultures, Research 
      on Disease Bioresources, National Institute of Biomedical Innovation , Osaka ,
      Japan.
FAU - Akamatsu, Wado
AU  - Akamatsu W
AD  - double dagger Department of Physiology, Keio University School of Medicine ,
      Shinjuku-ku, Tokyo , Japan.
FAU - Okada, Yohei
AU  - Okada Y
AD  - double daggerDepartment of Physiology, Keio University School of Medicine,
      Shinjuku-ku, Tokyo, Japan; section sign section signKanrinmaru-Project, School of
      Medicine, Keio University, Tokyo, Japan.
FAU - Okano, Hideyuki
AU  - Okano H
AD  - double dagger Department of Physiology, Keio University School of Medicine ,
      Shinjuku-ku, Tokyo , Japan.
FAU - Yamasaki, Mami
AU  - Yamasaki M
AD  - paragraph sign paragraph signDivision of Molecular Medicine, Institute for
      Clinical Research, Osaka National Hospital, National Hospital Organization,
      Osaka, Japan; ##Department of Neurosurgery, Osaka National Hospital, National
      Hospital Organization, Osaka, Japan; **Department of Pediatric Neurosurgery,
      Takatsuki General Hospital, Takatsuki, Osaka, Japan.
FAU - Kanemura, Yonehiro
AU  - Kanemura Y
AD  - daggerDivision of Regenerative Medicine, Institute for Clinical Research, Osaka
      National Hospital, National Hospital Organization, Osaka, Japan; ##Department of 
      Neurosurgery, Osaka National Hospital, National Hospital Organization, Osaka,
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20121101
PL  - United States
TA  - Cell Med
JT  - Cell medicine
JID - 101544564
PMC - PMC4733846
OTO - NOTNLM
OT  - Decidua
OT  - Induced pluripotent stem cells (iPSCs)
OT  - Mesenchymal cells
OT  - X-chromosome inactivation
EDAT- 2013/03/01 00:00
MHDA- 2013/03/01 00:01
CRDT- 2016/02/10 06:00
PHST- 2016/02/10 06:00 [entrez]
PHST- 2013/03/01 00:00 [pubmed]
PHST- 2013/03/01 00:01 [medline]
AID - 10.3727/215517912X658918 [doi]
AID - CM52 [pii]
PST - epublish
SO  - Cell Med. 2012 Nov 1;4(3):125-47. doi: 10.3727/215517912X658918. eCollection 2013
      Mar.


PMID- 25755473
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150310
LR  - 20201001
IS  - 0973-6883 (Print)
IS  - 0973-6883 (Linking)
VI  - 3
IP  - 1
DP  - 2013 Mar
TI  - Living Donor Liver Transplant is not a Transparent Activity in India.
PG  - 66-9
LID - 10.1016/j.jceh.2012.10.002 [doi]
AB  - Living donor liver transplant has gained rapid popularity in India as a life
      saving procedure for end stage liver disease. The undoubted benefit for the
      recipient is clouded by a few unfavorable outcomes in donors which have led to
      allegations of lack of transparency. These factors are easily remediable with an 
      attitude of self audit and self disclosure by transplant centers, enabling a
      truly informed consenting procedure.
FAU - Naidu, Sudeep
AU  - Naidu S
AD  - Dept of GI Surgery & Liver Transplantation, Army Hospital R & R, New Delhi
      110010, India.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121013
PL  - India
TA  - J Clin Exp Hepatol
JT  - Journal of clinical and experimental hepatology
JID - 101574137
PMC - PMC3940284
OTO - NOTNLM
OT  - ALF, acute liver failure
OT  - DDLT, deceased donor liver transplantation
OT  - LDLT, living donor liver transplant
OT  - THOA, Transplantation of Human Organs Act
OT  - UIDAI, Universal Identification Authority of India
OT  - WHO, World Health Organization
OT  - ethics
OT  - living donor liver transplant
OT  - transparency
EDAT- 2013/03/01 00:00
MHDA- 2013/03/01 00:01
CRDT- 2015/03/11 06:00
PHST- 2012/09/23 00:00 [received]
PHST- 2012/10/10 00:00 [accepted]
PHST- 2015/03/11 06:00 [entrez]
PHST- 2013/03/01 00:00 [pubmed]
PHST- 2013/03/01 00:01 [medline]
AID - 10.1016/j.jceh.2012.10.002 [doi]
AID - S0973-6883(12)00079-5 [pii]
PST - ppublish
SO  - J Clin Exp Hepatol. 2013 Mar;3(1):66-9. doi: 10.1016/j.jceh.2012.10.002. Epub
      2012 Oct 13.


PMID- 23442746
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150901
LR  - 20211021
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 13
IP  - 2
DP  - 2012 Feb 9
TI  - Retraction: Zhong Ye; Darya O. Mishchuk; Natasha S. Stephens and Carolyn M.
      Slupsky. Dextran sulfate sodium inhibits alanine synthesis in Caco-2 cells. Int. 
      J. Mol. Sci. 2011, 12, 2325-2335.
PG  - 1804
LID - 10.3390/ijms13021804 [doi]
AB  - It has been brought to our attention by the corresponding author that the results
      presented this article [1] are in error due to the fact that the media supplement
      glutaMAX was used in place of L-glutamine for culture of the control cells, while
      L-glutamine was used for culture of the treated cells. All authors have confirmed
      that the reported result could not be reproduced using the correct culture
      conditions. We would like to thank the authors for pointing out this error
      thereby upholding the ethics of scientific publication. The Editorial Team and
      Publisher have agreed with the authors that this manuscript should be retracted. 
      We apologize for any inconvenience this may have caused.
LA  - eng
PT  - Retraction of Publication
DEP - 20120209
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
ROF - Ye Z, Mishchuk DO, Stephens NS, Slupsky CM. Int J Mol Sci. 2011;12(4):2325-35.
      PMID: 21731444
PMC - PMC3291994
GN  - NLM: Original DateCompleted: 20130228
EDAT- 2013/02/28 06:00
MHDA- 2013/02/28 06:01
CRDT- 2013/02/28 06:00
PHST- 2012/01/08 00:00 [received]
PHST- 2013/02/28 06:00 [entrez]
PHST- 2013/02/28 06:00 [pubmed]
PHST- 2013/02/28 06:01 [medline]
AID - ijms13021804 [pii]
AID - 10.3390/ijms13021804 [doi]
PST - epublish
SO  - Int J Mol Sci. 2012 Feb 9;13(2):1804. doi: 10.3390/ijms13021804.


PMID- 23441398
OWN - NLM
STAT- MEDLINE
DCOM- 20130409
LR  - 20210105
IS  - 1210-7778 (Print)
IS  - 1210-7778 (Linking)
VI  - 20
IP  - 4
DP  - 2012 Dec
TI  - Avicenna's doctrine and institutional review board in international bio-medical
      research.
PG  - 297-8
AB  - Avicenna, an outstanding Persian physician and philosopher (980 AD-1037 AD),
      established a clinical treaty, or doctrine, without which medical experimentation
      would not have progressed. This doctrine emphasizes the ultimate divine power of 
      God or a higher being over healing and mandates the patients' well-being as the
      crucial aspect in all medical care and experiments. The Institutional Review
      Board, as the ethical body that oversees clinical research, is in line with this 
      doctrine. However, the lack of a homogenous and internationally recognized code
      of ethics, the decentralized work of ethics oversight committees, the improper
      implementation of established ethical standards and a shortage of scientific
      auditing capacities have raised concerns over the possible exploitation of
      vulnerable populations.
FAU - Radfar, Amir
AU  - Radfar A
AD  - University of Massachusetts, Lowell, PO Box 17584, Encino, California 91416, USA.
      aradf001@fiu.edu
FAU - Kazerouninia, Chekameh
AU  - Kazerouninia C
FAU - Filip, Irina
AU  - Filip I
FAU - Patriche, Diana
AU  - Patriche D
FAU - Ahmadi, Seyed Ahmad Asgharzadeh
AU  - Ahmadi SA
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - Czech Republic
TA  - Cent Eur J Public Health
JT  - Central European journal of public health
JID - 9417324
SB  - IM
MH  - Biomedical Research/*history
MH  - Ethics Committees, Research/*history
MH  - Evidence-Based Medicine/history
MH  - History, Medieval
MH  - Human Experimentation/*history
MH  - Humans
MH  - Medicine, Arabic
MH  - Persia
MH  - Philosophy, Medical/*history
EDAT- 2013/02/28 06:00
MHDA- 2013/04/10 06:00
CRDT- 2013/02/28 06:00
PHST- 2013/02/28 06:00 [entrez]
PHST- 2013/02/28 06:00 [pubmed]
PHST- 2013/04/10 06:00 [medline]
AID - 10.21101/cejph.a3792 [doi]
PST - ppublish
SO  - Cent Eur J Public Health. 2012 Dec;20(4):297-8. doi: 10.21101/cejph.a3792.


PMID- 23440002
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130227
LR  - 20220408
IS  - 2141-9248 (Print)
IS  - 2141-9248 (Linking)
VI  - 2
IP  - 2
DP  - 2012 Jul
TI  - Assessment of mild cognitive impairment with mini mental state examination among 
      adults in southeast Nigeria.
PG  - 99-102
LID - 10.4103/2141-9248.105653 [doi]
AB  - BACKGROUND: Mild cognitive impairment is a recently described neuropsychiatric
      entity with the possibility of evolving into overt dementia. It has been found to
      respond to therapeutic intervention, thus halting or significantly retarding the 
      progression to dementia. Resource-poor countries like Nigeria can hardly afford
      to provide optimal care for dementia patients. Knowledge about mild cognitive
      impairment in Nigeria is limited. An appreciation of the probable burden may help
      stimulate and galvanize appropriate public health policies in response. AIM: This
      cross-sectional, descriptive study sought to determine the frequency of
      subclinical mental state abnormalities in a cohort of apparently normal adult
      Nigerians. SUBJECTS AND METHODS: One hundred and thirty-five apparently normal
      adult Nigerians of both sexes seen at the University of Nigeria Teaching
      Hospital, Enugu, were interviewed. The Mini Mental State Examination (MMSE) of
      Folstein, Folstein, and McHugh was used to assess cognitive function in each
      subject at a single instance. The results obtained were analyzed using SPSS
      version 11.3 (Chicago, IL). Consent was obtained from each person and approval
      obtained from the hospital's ethics review board. RESULTS: A cut-off score of
      >/=17 was obtained for normal cognitive function in this population using the
      MMSE. Minimum score obtained was 12, while the maximum score was 30. A mean (2SD)
      of 24.84 (7.94) was obtained on analysis of the overall MMSE scores of the 135
      individuals. Cognitive impairment was identified in 5.93% (8/135) of the subjects
      examined. These persons thus represent otherwise normal functional individuals
      with unrecognized mild cognitive impairment who may be at risk of developing
      overt dementia in future. CONCLUSION: The concept of mild cognitive impairment
      needs further large-scale studies in Nigerians with possible multi-centre
      participation to fully elucidate the scope of the problem. Strategies for the
      appropriate management of dementia need to be strengthened.
FAU - Onwuekwe, Io
AU  - Onwuekwe I
AD  - Department of Medicine, Neurology Unit, University of Nigeria Teaching Hospital, 
      P.M.B. 01129, Enugu, Nigeria.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Ann Med Health Sci Res
JT  - Annals of medical and health sciences research
JID - 101585351
PMC - PMC3573524
OTO - NOTNLM
OT  - Cognitive impairment
OT  - Mini Mental State Examination
OT  - Nigerians
EDAT- 2013/02/27 06:00
MHDA- 2013/02/27 06:01
CRDT- 2013/02/27 06:00
PHST- 2013/02/27 06:00 [entrez]
PHST- 2013/02/27 06:00 [pubmed]
PHST- 2013/02/27 06:01 [medline]
AID - 10.4103/2141-9248.105653 [doi]
AID - AMHSR-2-99 [pii]
PST - ppublish
SO  - Ann Med Health Sci Res. 2012 Jul;2(2):99-102. doi: 10.4103/2141-9248.105653.


PMID- 23438404
OWN - NLM
STAT- MEDLINE
DCOM- 20130417
LR  - 20181202
IS  - 1558-4240 (Electronic)
IS  - 0749-0720 (Linking)
VI  - 29
IP  - 1
DP  - 2013 Mar
TI  - Prevention and management of surgical pain in cattle.
PG  - 157-84
LID - 10.1016/j.cvfa.2012.11.006 [doi]
LID - S0749-0720(12)00094-1 [pii]
AB  - Management of pain continues to be an important consideration in livestock on
      which surgical procedures are performed. A balance must be achieved between the
      need to mitigate discomfort and the economic constraints of the production
      enterprise. Moral and ethical dilemmas have increased among consumers and these
      concerns have stimulated interest to reexamine the methods used to achieve the
      shared goals of humane production of safe, affordable animal products for human
      consumption. This article discusses drug and anesthetic protocols for field
      surgery of cattle, including nonsteroidal antiinflammatory drugs, opioids, local 
      and regional anesthesia, epidural anesthesia, and electroacupuncture.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Anderson, David E
AU  - Anderson DE
AD  - Large Animal Clinical Sciences, College of Veterinary Medicine, University of
      Tennessee, Knoxville, TN 37996, USA. david.anderson@utk.edu
FAU - Edmondson, Misty A
AU  - Edmondson MA
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121223
PL  - United States
TA  - Vet Clin North Am Food Anim Pract
JT  - The Veterinary clinics of North America. Food animal practice
JID - 8511905
SB  - IM
MH  - Analgesia/methods/*veterinary
MH  - Anesthesia/methods/*veterinary
MH  - Animal Welfare
MH  - Animals
MH  - Cattle/*surgery
MH  - Pain Management/*veterinary
MH  - Pain, Postoperative/drug therapy/prevention & control/*veterinary
EDAT- 2013/02/27 06:00
MHDA- 2013/04/19 06:00
CRDT- 2013/02/27 06:00
PHST- 2013/02/27 06:00 [entrez]
PHST- 2013/02/27 06:00 [pubmed]
PHST- 2013/04/19 06:00 [medline]
AID - S0749-0720(12)00094-1 [pii]
AID - 10.1016/j.cvfa.2012.11.006 [doi]
PST - ppublish
SO  - Vet Clin North Am Food Anim Pract. 2013 Mar;29(1):157-84. doi:
      10.1016/j.cvfa.2012.11.006. Epub 2012 Dec 23.


PMID- 23437677
OWN - NLM
STAT- MEDLINE
DCOM- 20130409
LR  - 20130226
IS  - 8756-8160 (Print)
IS  - 8756-8160 (Linking)
VI  - 28
IP  - 2
DP  - 2012 Fall
TI  - Other people's lives: reflections on medicine, ethics, and euthanasia.
PG  - 95-359
FAU - Fenigsen, Richard
AU  - Fenigsen R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Issues Law Med
JT  - Issues in law & medicine
JID - 8511295
SB  - IM
MH  - *Ethics, Medical
MH  - Euthanasia/*ethics
MH  - Humans
MH  - *Physician-Patient Relations
MH  - Physicians
MH  - Public Opinion
EDAT- 2013/02/27 06:00
MHDA- 2013/04/10 06:00
CRDT- 2013/02/27 06:00
PHST- 2013/02/27 06:00 [entrez]
PHST- 2013/02/27 06:00 [pubmed]
PHST- 2013/04/10 06:00 [medline]
PST - ppublish
SO  - Issues Law Med. 2012 Fall;28(2):95-359.


PMID- 23250258
OWN - NLM
STAT- MEDLINE
DCOM- 20130401
LR  - 20190911
IS  - 0080-6234 (Print)
IS  - 0080-6234 (Linking)
VI  - 46 Spec No
DP  - 2012 Oct
TI  - Dignity in care: where next for nursing ethics scholarship and research?
PG  - 51-7
LID - S0080-62342012000700008 [pii]
AB  - Dignity is recognised as both a central and also a contested value in bioethics
      discourse. The aim of this manuscript is to examine some of the key strands of
      the extensive body of dignity scholarship and research literature as it relates
      to nursing ethics and practice. The method is a critical appraisal of selected
      articles published in Nursing Ethics and other key manuscripts and texts
      identified by researchers in the UK and Brazil as influential. The results
      suggest a wide and rather confusing range of perspectives and findings albeit
      with some overall themes relating to objective and subjective features of
      dignity. In conclusion, the authors point to the need for more sustained
      philosophical engagement contextualising human dignity within a plurality of
      professional values. Future empirical work should explore what matters to
      patients, families, professionals and citizens in different cultural contexts
      rather than foregrounding qualitative research with such a contested concept.
FAU - Gallagher, Ann
AU  - Gallagher A
AD  - International Centre for Nursing Ethics, School of Health and Social Care,
      University of Surrey, UK. a.gallagher@surrey.ac.uk
FAU - Zoboli, Elma Lourdes Campos Pavone
AU  - Zoboli EL
FAU - Ventura, Carla
AU  - Ventura C
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - Rev Esc Enferm USP
JT  - Revista da Escola de Enfermagem da U S P
JID - 0242726
MH  - *Ethics, Nursing
MH  - Humans
MH  - *Nursing Research
MH  - *Personhood
EDAT- 2013/02/27 06:00
MHDA- 2013/04/02 06:00
CRDT- 2012/12/20 06:00
PHST- 2012/08/10 00:00 [received]
PHST- 2012/09/14 00:00 [accepted]
PHST- 2012/12/20 06:00 [entrez]
PHST- 2013/02/27 06:00 [pubmed]
PHST- 2013/04/02 06:00 [medline]
AID - S0080-62342012000700008 [pii]
AID - 10.1590/s0080-62342012000700008 [doi]
PST - ppublish
SO  - Rev Esc Enferm USP. 2012 Oct;46 Spec No:51-7. doi:
      10.1590/s0080-62342012000700008.


PMID- 23431845
OWN - NLM
STAT- MEDLINE
DCOM- 20130409
LR  - 20130225
IS  - 1320-159X (Print)
IS  - 1320-159X (Linking)
VI  - 20
IP  - 2
DP  - 2012 Dec
TI  - Ethics committees in New Zealand.
PG  - 266-72
AB  - The ethical review of research in New Zealand after the Cartwright Report of 1988
      produced a major change in safeguards for and empowerment of participants in
      health care research. Several reforms since then have streamlined some processes 
      but also seriously weakened some of the existing safeguards. The latest reforms, 
      against the advice of various ethics bodies and the New Zealand Law Society,
      further reduced and attenuated the role of ethics committees so that New Zealand 
      has moved from being a world leader in ethical review processes to there being
      serious doubt whether it is in conformity to international Conventions and codes.
      The latest round of reforms, seemingly driven by narrow economic aspirations,
      anecdote and innuendo, have occurred without any clear evidence of dysfunction in
      the system nor any plans for the resourcing required to improve quality of
      ethical review or to audit the process. It is of serious concern both to
      ethicists and medical lawyers in New Zealand that such hasty and poorly
      researched changes should have been made which threaten the hard-won gains of the
      Cartwright reforms.
FAU - Gillett, Grant
AU  - Gillett G
AD  - Dunedin Hospital and Otago Bioethics Centre, University of Otago Medical School, 
      New Zealand. grant.gillett@stonebow.otago.ac.nz
FAU - Douglass, Alison
AU  - Douglass A
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Law Med
JT  - Journal of law and medicine
JID - 9431853
SB  - IM
MH  - Ethical Review/standards
MH  - Ethics Committees, Research/*legislation & jurisprudence
MH  - Human Experimentation/*ethics/legislation & jurisprudence
MH  - Humans
MH  - New Zealand
EDAT- 2013/02/26 06:00
MHDA- 2013/04/10 06:00
CRDT- 2013/02/26 06:00
PHST- 2013/02/26 06:00 [entrez]
PHST- 2013/02/26 06:00 [pubmed]
PHST- 2013/04/10 06:00 [medline]
PST - ppublish
SO  - J Law Med. 2012 Dec;20(2):266-72.


PMID- 23430494
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130225
LR  - 20211021
IS  - 2192-8304 (Print)
IS  - 2192-8304 (Linking)
VI  - 7
DP  - 2013
TI  - Successful Live Birth following Preimplantation Genetic Diagnosis for
      Phenylketonuria in Day 3 Embryos by Specific Mutation Analysis and Elective
      Single Embryo Transfer.
PG  - 49-54
LID - 10.1007/8904_2012_140 [doi]
AB  - Phenylketonuria (PKU) is an autosomal recessive inherited metabolic disorder
      caused by a complete or near-complete deficiency of the liver enzyme
      phenylalanine hydroxylase (PAH), which converts the amino acid phenylalanine to
      tyrosine, leading to the increase of blood and tissue concentration of
      phenylalanine to toxic levels. PKU is not life threatening but is treated through
      lifelong dietary management. If untreated, it can lead to severe learning
      disability, brain function abnormalities, behavioural and neurological problems. 
      The non-life threatening nature of PKU has until now caused some debate on
      whether to licence its detection by preimplantation genetic diagnosis (PGD). We
      report the first successful live birth in the UK following single cell embryo
      biopsy and PGD for the detection of two different mutations in the (PAH) gene.
      This case highlights both an important scientific development as well as the
      ethical challenge in offering couples who carry PKU this new reproductive option 
      when starting their family.
FAU - Lavery, Stuart
AU  - Lavery S
AD  - IVF Hammersmith, Hammersmith Hospital, Du Cane Road, London, W12 0HS, UK,
      stuart.lavery@imperial.ac.uk.
FAU - Abdo, Dima
AU  - Abdo D
FAU - Kotrotsou, Mara
AU  - Kotrotsou M
FAU - Trew, Geoff
AU  - Trew G
FAU - Konstantinidis, Michalis
AU  - Konstantinidis M
FAU - Wells, Dagan
AU  - Wells D
LA  - eng
PT  - Journal Article
DEP - 20120331
PL  - United States
TA  - JIMD Rep
JT  - JIMD reports
JID - 101568557
PMC - PMC3575040
EDAT- 2013/02/23 06:00
MHDA- 2013/02/23 06:01
CRDT- 2013/02/23 06:00
PHST- 2011/12/11 00:00 [received]
PHST- 2012/03/05 00:00 [accepted]
PHST- 2012/02/15 00:00 [revised]
PHST- 2013/02/23 06:00 [entrez]
PHST- 2013/02/23 06:00 [pubmed]
PHST- 2013/02/23 06:01 [medline]
AID - 10.1007/8904_2012_140 [doi]
PST - ppublish
SO  - JIMD Rep. 2013;7:49-54. doi: 10.1007/8904_2012_140. Epub 2012 Mar 31.


PMID- 23429172
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130225
LR  - 20220331
IS  - 2008-2142 (Print)
IS  - 2008-2142 (Linking)
VI  - 22
IP  - 4
DP  - 2012 Dec
TI  - Key ethical issues in pediatric research: islamic perspective, Iranian
      experience.
PG  - 435-44
AB  - OBJECTIVE: The importance of pediatric research especially in the ethically
      proven trials resulted in considerable legislative attempts in association with
      compiling ethical guidelines. Because of children's vulnerability conducting
      pediatric research raises different ethical issues; the two most important of
      which are informed consent and risk-benefit assessment. Differences in religious 
      and socio-cultural context limit implication of ethical standards. METHODS: At
      the aim of finding a solution we critically reviewed guidelines, and literatures 
      as well as Islamic points in addition to comparing different viewpoints in
      application of ethical standards in pediatric research. FINDINGS: The literature 
      review showed that pediatric research guidelines and authors' viewpoints have the
      same basic ethical core, but there are some variations; depend on cultural,
      religious, and social differences. Furthermore, these standards have some
      limitations in defining informed consent according to child's age and capacity
      upon application. CONCLUSION: In this regard Islamic approach and definition
      about growth development and puberty sheds light and clarifies a clearer and more
      rational address to the issue.
FAU - Mobasher, Mina
AU  - Mobasher M
AD  - Medical Ethics and History of Medicine Research Center, Tehran University of
      Medical Sciences, Tehran, Iran ; Faculty of Medicine, Kerman University of
      Medical Sciences, Kerman, Iran.
FAU - Salari, Pooneh
AU  - Salari P
FAU - Larijani, Bagher
AU  - Larijani B
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Iran J Pediatr
JT  - Iranian journal of pediatrics
JID - 101274724
PMC - PMC3533141
OTO - NOTNLM
OT  - Children
OT  - Ethics
OT  - Islamic Law
OT  - Pediatric Research
EDAT- 2013/02/23 06:00
MHDA- 2013/02/23 06:01
CRDT- 2013/02/23 06:00
PHST- 2011/09/13 00:00 [received]
PHST- 2012/02/12 00:00 [revised]
PHST- 2012/03/10 00:00 [accepted]
PHST- 2013/02/23 06:00 [entrez]
PHST- 2013/02/23 06:00 [pubmed]
PHST- 2013/02/23 06:01 [medline]
PST - ppublish
SO  - Iran J Pediatr. 2012 Dec;22(4):435-44.


PMID- 23427634
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20191210
IS  - 1048-5317 (Print)
IS  - 1048-5317 (Linking)
VI  - 24
IP  - 7
DP  - 2012 Nov-Dec
TI  - Tips to keep your advertising legal and ethical.
PG  - 56-7, 59
FAU - Rapp, Cliff
AU  - Rapp C
AD  - The Doctor's Company/FPIC.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Todays FDA
JT  - Today's FDA : official monthly journal of the Florida Dental Association
JID - 9012957
MH  - *Advertising/ethics/legislation & jurisprudence
MH  - Florida
MH  - Humans
MH  - *Practice Management, Dental/ethics/legislation & jurisprudence
EDAT- 2013/02/23 06:00
MHDA- 2013/03/13 06:00
CRDT- 2013/02/23 06:00
PHST- 2013/02/23 06:00 [entrez]
PHST- 2013/02/23 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
PST - ppublish
SO  - Todays FDA. 2012 Nov-Dec;24(7):56-7, 59.


PMID- 23425875
OWN - NLM
STAT- MEDLINE
DCOM- 20160408
LR  - 20161021
IS  - 0351-3254 (Print)
IS  - 0351-3254 (Linking)
VI  - 33
IP  - 2
DP  - 2012
TI  - Personality profiles and depression in haemodialysis patients.
PG  - 117-29
AB  - Chronic haemodyalisis is an established treatment of end stage renal disease
      which maintains the lives of individuals who otherwise would have succumbed to a 
      uraemic death. However, this method of treatment raises certain psychological,
      social and ethical issues, where depression and stress are the most common. This 
      article is concerned with the evaluation of depression and the psychological
      characteristics of patients treated by chronic maintenance haemodyalisis. Using
      two psychometric tests (Beck Depression Inventory and MMPI-201) we obtained a
      significant incidence of depression (90.63%) in patients recruited from two
      centres for dia-lysis in Skopje, where even the severe form was unrecognized and 
      untreated. The psychological profiles confirmed hypersensitivity, depressive
      mood, frequent interpersonal problems, and withdrawal from friends and relatives.
      Latent aggressiveness could be destructive for their social communications. In
      order to overcome the depression some response measures such as relaxation
      training, psychological support, music therapy or peripheral biofeedback are
      recommended.
FAU - Pop-Jordanova, N
AU  - Pop-Jordanova N
AD  - Macedonian Academy of Sciences and Arts, Skopje, R. Macedonia.
FAU - Polenakovic, M
AU  - Polenakovic M
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Prilozi
JT  - Prilozi
JID - 101189513
SB  - IM
MH  - Depression/*epidemiology
MH  - Female
MH  - Humans
MH  - Kidney Failure, Chronic/*psychology/*therapy
MH  - Male
MH  - Middle Aged
MH  - Personality Disorders/*epidemiology
MH  - Psychiatric Status Rating Scales
MH  - Psychometrics
MH  - Renal Dialysis/*psychology
EDAT- 2013/02/22 06:00
MHDA- 2016/04/09 06:00
CRDT- 2013/02/22 06:00
PHST- 2013/02/22 06:00 [entrez]
PHST- 2013/02/22 06:00 [pubmed]
PHST- 2016/04/09 06:00 [medline]
PST - ppublish
SO  - Prilozi. 2012;33(2):117-29.


PMID- 23424962
OWN - NLM
STAT- MEDLINE
DCOM- 20130827
LR  - 20150612
IS  - 0042-8450 (Print)
IS  - 0042-8450 (Linking)
VI  - 69
IP  - 12
DP  - 2012 Dec
TI  - The impact of thickness of resorbable membrane of human origin on the
      ossification of bone defects: a pathohistologic study.
PG  - 1076-83
AB  - BACKGROUND/AIM: A wide range of resorbable and non-resorbable membranes have been
      investigated over the last two decades. The barrier membrane protects the defect 
      from ingrowth of soft tissue cells and allows bone progenitor cells to develop
      bone within a blood clot that is formed beneath the barrier membrane. The
      membranes are applied to reconstruct small bony defect prior to implantation, to 
      cover dehiscences and fenestrations around dental implants. The aim of this study
      was to evaluate the influence of human resorbable demineralized membrane (RHDM)
      thickness on bone regeneration. METHODS: The experiment, approved by Ethical
      Committee, was performed on 6 dogs and conducted into three phases. Bone defects 
      were created in all the 6 dogs on the left side of the mandible, 8 weeks after
      extraction of second, third and fourth premolars. One defect was covered with
      RHDM 100 micro thick, one with RHDM 200 micro thick, and the third defect left
      empty (control defect). The histopathological analysis was done 2, 4 and 6 months
      after the surgery. In the third phase samples of bone tissue were taken and
      subjected to histopathological analysis. RESULTS: In all the 6 dogs the defects
      treated with RHDM 200 micro thick showed higher level of bone regeneration in
      comparison with the defect treated with RHDM 100 micro thick and especially with 
      empty defect. CONCLUSION: Our results demonstrated that the thicker membrane
      showed the least soft tissue ingrowths and promoted better bone formation at 6
      months compared with a thinner one.
FAU - Bubalo, Marija
AU  - Bubalo M
AD  - Dentistry Clinic, Military Medical Academy, Belgrade, Serbia. bubalom@sezampro.rs
FAU - Lazic, Zoran
AU  - Lazic Z
FAU - Matic, Smiljana
AU  - Matic S
FAU - Tatic, Zoran
AU  - Tatic Z
FAU - Milovic, Radomir
AU  - Milovic R
FAU - Curcin, Aleksandra Petkovic
AU  - Curcin AP
FAU - Djurdjevic, Dragan
AU  - Djurdjevic D
FAU - Loncarevic, Slobodan
AU  - Loncarevic S
LA  - eng
PT  - Journal Article
PL  - Serbia
TA  - Vojnosanit Pregl
JT  - Vojnosanitetski pregled
JID - 21530700R
SB  - IM
MH  - *Absorbable Implants
MH  - Animals
MH  - Bone Regeneration/*physiology
MH  - Dogs
MH  - *Guided Tissue Regeneration
MH  - Humans
MH  - Mandible/*physiopathology/surgery
MH  - *Membranes
EDAT- 2013/02/22 06:00
MHDA- 2013/08/28 06:00
CRDT- 2013/02/22 06:00
PHST- 2013/02/22 06:00 [entrez]
PHST- 2013/02/22 06:00 [pubmed]
PHST- 2013/08/28 06:00 [medline]
PST - ppublish
SO  - Vojnosanit Pregl. 2012 Dec;69(12):1076-83.


PMID- 23424901
OWN - NLM
STAT- MEDLINE
DCOM- 20130411
LR  - 20130221
IS  - 0882-1046 (Print)
IS  - 0882-1046 (Linking)
VI  - 29
IP  - 1
DP  - 2012 Fall
TI  - Protecting a vulnerable population with little regulatory framework: a
      comparative analysis of international guidelines for pediatric research ethics.
PG  - 36-71
FAU - Mullins-Owens, Heather L
AU  - Mullins-Owens HL
FAU - Henderson, Macey L
AU  - Henderson ML
FAU - Henderson, Jason
AU  - Henderson J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Contemp Health Law Policy
JT  - The Journal of contemporary health law and policy
JID - 8510462
SB  - IM
MH  - Child
MH  - Clinical Trials as Topic/*ethics/*legislation & jurisprudence
MH  - Culture
MH  - Ethics Committees, Research
MH  - Human Experimentation/ethics/legislation & jurisprudence
MH  - Humans
MH  - Informed Consent By Minors/legislation & jurisprudence
MH  - *Internationality
MH  - Parental Consent/legislation & jurisprudence
MH  - Pediatrics/*ethics
MH  - Practice Guidelines as Topic
EDAT- 2013/02/22 06:00
MHDA- 2013/04/12 06:00
CRDT- 2013/02/22 06:00
PHST- 2013/02/22 06:00 [entrez]
PHST- 2013/02/22 06:00 [pubmed]
PHST- 2013/04/12 06:00 [medline]
PST - ppublish
SO  - J Contemp Health Law Policy. 2012 Fall;29(1):36-71.


PMID- 23420996
OWN - NLM
STAT- MEDLINE
DCOM- 20130319
LR  - 20130220
IS  - 1122-6714 (Print)
IS  - 1122-6714 (Linking)
VI  - 117
IP  - 2
DP  - 2012
TI  - The fundamental role of morphology in experimental neurotoxicology: the example
      of chemotherapy-induced peripheral neurotoxicity.
PG  - 75-97
AB  - The peripheral nervous system is a frequent target of toxic agents. The accurate 
      identification of the sites of neurotoxic action through the morphological
      characterization of reliable in vivo models or in vitro systems can give
      fundamental clues when investigating the pathogenesis and interpreting the
      clinical features of drug-induced neuropathy. The morphological approach has been
      used to investigate almost all the anticancer drugs able to induce
      chemotherapy-induced peripheral neurotoxicity, i.e. platinum drugs, antitubulins 
      and proteasome inhibitors. No models have ever been described for thalidomide.
      This review demonstrates that any pathogenetic study on chemotherapy-induced
      peripheral neurotoxicity must be based on solid morphological observations
      obtained in reliable animal and in vitro models. This is particularly true in
      this setting, since the availability of tissues of human origin is extremely
      limited. In fact, peripheral (generally sural) nerve biopsies are never required 
      for diagnostic purposes in chemotherapy-treated cancer patients, and their use
      for a purely scientific aim, although potentially very informative, is not
      ethical. Moreover, several neurotoxic drugs target the dorsal root ganglia
      neurons, and it is very difficult to obtain high-quality specimens even from
      early autopsies. It is, therefore, our opinion that an extensive morphological
      assessment of the in vitro and in vivo effect of any potentially neurotoxic
      antineoplastic drugs, as well as of neuroprotectant agents, should be taken into 
      consideration right from the earliest stages of their development.
FAU - Marmiroli, Paola
AU  - Marmiroli P
AD  - Department of Neuroscience and Biomedical Technology, University of
      Milano-Bicocca, Via Cadore 48, I-20900 Monza, Italy. paola.marmiroli@unimib.it
FAU - Nicolini, Gabriella
AU  - Nicolini G
FAU - Miloso, Mariarosaria
AU  - Miloso M
FAU - Scuteri, Arianna
AU  - Scuteri A
FAU - Cavaletti, Guido
AU  - Cavaletti G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Italy
TA  - Ital J Anat Embryol
JT  - Italian journal of anatomy and embryology = Archivio italiano di anatomia ed
      embriologia
JID - 9612303
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/adverse effects/*therapeutic use/*toxicity
MH  - Cell Culture Techniques/methods
MH  - Disease Models, Animal
MH  - Humans
MH  - Neurotoxicity Syndromes/*pathology/physiopathology
MH  - Peripheral Nervous System Diseases/*chemically induced/*pathology/physiopathology
MH  - Toxicology/*methods/standards
EDAT- 2013/02/21 06:00
MHDA- 2013/03/21 06:00
CRDT- 2013/02/21 06:00
PHST- 2013/02/21 06:00 [entrez]
PHST- 2013/02/21 06:00 [pubmed]
PHST- 2013/03/21 06:00 [medline]
PST - ppublish
SO  - Ital J Anat Embryol. 2012;117(2):75-97.


PMID- 23420941
OWN - NLM
STAT- MEDLINE
DCOM- 20130308
LR  - 20171116
IS  - 1054-6863 (Print)
IS  - 1054-6863 (Linking)
VI  - 22
IP  - 4
DP  - 2012 Dec
TI  - Between reason and coercion: ethically permissible influence in health care and
      health policy contexts.
PG  - 345-66
AB  - In bioethics, the predominant categorization of various types of influence has
      been a tripartite classification of rational persuasion (meaning influence by
      reason and argument), coercion (meaning influence by irresistible threats-or on a
      few accounts, offers), and manipulation (meaning everything in between). The
      standard ethical analysis in bioethics has been that rational persuasion is
      always permissible, and coercion is almost always impermissible save a few cases 
      such as imminent threat to self or others. However, many forms of influence fall 
      into the broad middle terrain-and this terrain is in desperate need of conceptual
      refining and ethical analysis in light of recent interest in using principles
      from behavioral science to influence health decisions and behaviors. This paper
      aims to address the neglected space between rational persuasion and coercion in
      bioethics. First, I argue for conceptual revisions that include removing the
      "manipulation" label and relabeling this space "nonargumentative influence," with
      two subtypes: "reason-bypassing" and "reason-countering." Second, I argue that
      bioethicists have made the mistake of relying heavily on the conceptual
      categories themselves for normative work and instead should assess the ethical
      permissibility of a particular instance of influence by asking several key
      ethical questions, which I elucidate, that relate to (1) the impact of the form
      of influence on autonomy and (2) the relationship between the influencer and the 
      influenced. Finally, I apply my analysis to two examples of nonargumentative
      influence in health care and health policy: (1) governmental agencies such as the
      Food and Drug Administration (FDA) trying to influence the public to be healthier
      using nonargumentative measures such as vivid images on cigarette packages to
      make more salient the negative effects of smoking, and (2) a physician framing a 
      surgery in terms of survival rates instead of mortality rates to influence her
      patient to consent to the surgery.
FAU - Blumenthal-Barby, J S
AU  - Blumenthal-Barby JS
AD  - Center for Medical Ethics and Health Policy, Baylor College of Medicine, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Kennedy Inst Ethics J
JT  - Kennedy Institute of Ethics journal
JID - 9109135
SB  - IM
MH  - *Coercion
MH  - Delivery of Health Care/*ethics
MH  - Ethical Analysis
MH  - Ethics, Medical
MH  - Health Policy
MH  - Humans
MH  - Informed Consent/*ethics
MH  - *Persuasive Communication
MH  - Product Labeling/*ethics
MH  - Smoking Cessation
MH  - Smoking Prevention
MH  - Surgical Procedures, Operative/mortality
MH  - Survival Rate
MH  - Tobacco Products
MH  - United States
MH  - United States Food and Drug Administration
EDAT- 2013/02/21 06:00
MHDA- 2013/03/09 06:00
CRDT- 2013/02/21 06:00
PHST- 2013/02/21 06:00 [entrez]
PHST- 2013/02/21 06:00 [pubmed]
PHST- 2013/03/09 06:00 [medline]
PST - ppublish
SO  - Kennedy Inst Ethics J. 2012 Dec;22(4):345-66.


PMID- 23420939
OWN - NLM
STAT- MEDLINE
DCOM- 20130308
LR  - 20130220
IS  - 1054-6863 (Print)
IS  - 1054-6863 (Linking)
VI  - 22
IP  - 4
DP  - 2012 Dec
TI  - Toward a naturalized clinical ethics.
PG  - 289-306
AB  - Clinical ethicists tend to see themselves as moral experts to be called in when
      clinicians encounter a particularly difficult moral problem. Drawing on a
      naturalized moral epistemology, we argue that clinicians already have the moral
      knowledge they need-the norms and values that guide clinical practice are built
      right into the various health care professions. To reflect on their practice,
      clinicians need to (a) be aware of their own professional norms and values; (b)
      be able to express them to their colleagues, their patients, and the patients'
      families; and (c) work together with these other actors to provide ethically
      responsible care. The ethicist's job is to use her own training in three kinds of
      philosophical reflection as the basis for teaching clinicians how to think about 
      what they do.
FAU - Verkerk, Marian
AU  - Verkerk M
AD  - University of Groningen.
FAU - Lindemann, Hilde
AU  - Lindemann H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Kennedy Inst Ethics J
JT  - Kennedy Institute of Ethics journal
JID - 9109135
SB  - IM
MH  - Ethical Analysis/*methods
MH  - *Ethicists/standards
MH  - Ethics, Clinical/*education
MH  - Ethics, Medical/education
MH  - Ethics, Nursing/education
MH  - Humans
MH  - Informed Consent/ethics
MH  - *Knowledge
MH  - *Morals
MH  - *Professional Competence/standards
MH  - *Thinking/ethics
MH  - Third-Party Consent
EDAT- 2013/02/21 06:00
MHDA- 2013/03/09 06:00
CRDT- 2013/02/21 06:00
PHST- 2013/02/21 06:00 [entrez]
PHST- 2013/02/21 06:00 [pubmed]
PHST- 2013/03/09 06:00 [medline]
PST - ppublish
SO  - Kennedy Inst Ethics J. 2012 Dec;22(4):289-306.


PMID- 23419443
OWN - NLM
STAT- MEDLINE
DCOM- 20130805
LR  - 20171116
IS  - 1776-2588 (Electronic)
IS  - 0761-8425 (Linking)
VI  - 30
IP  - 2
DP  - 2013 Feb
TI  - [Diagnosis and management of lung cancer during pregnancy].
PG  - 125-36
LID - 10.1016/j.rmr.2012.11.003 [doi]
LID - S0761-8425(12)01003-0 [pii]
AB  - The incidence of lung cancer during pregnancy is very low, but it is becoming
      more frequent in industrialized countries both because of the increase in smoking
      in young women and because women are becoming pregnant later in life. Usually,
      the cancer has a poor prognosis due to the presence of metastatic disease at the 
      time of diagnosis. Diagnosis and management are delicate, and should deal with
      the gestational age, the maternal prognosis, the fetal toxicity of treatments,
      but also with the worsening of maternal prognosis and the risk of neoplastic
      cells being transmitted to the fetus in case of delayed treatment. Psychological 
      and ethical considerations complicate the decision process. We present a review
      of the epidemiology, clinical characteristics, management, and prognosis
      concerning lung cancer during pregnancy. Finally, it is important to remember
      that young women with lung cancer should be advised to use a reliable form of
      contraception.
CI  - Copyright (c) 2012 SPLF. Published by Elsevier Masson SAS. All rights reserved.
FAU - Kerjouan, M
AU  - Kerjouan M
AD  - Service de pneumologie, centre hospitalier universitaire de Rennes, hopital
      Pontchaillou, 2, rue Henri-Le-Guilloux, 35033 Rennes cedex 9, France.
      mallorie.kerjouan@chu-rennes.fr
FAU - Jouneau, S
AU  - Jouneau S
FAU - Corre, R
AU  - Corre R
FAU - Le Ho, H
AU  - Le Ho H
FAU - Pracht, M
AU  - Pracht M
FAU - Lena, H
AU  - Lena H
FAU - Desrues, B
AU  - Desrues B
LA  - fre
PT  - Journal Article
PT  - Review
TT  - Le cancer bronchique de la femme enceinte : prise en charge diagnostique et
      therapeutique en 2012.
DEP - 20121231
PL  - France
TA  - Rev Mal Respir
JT  - Revue des maladies respiratoires
JID - 8408032
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Abnormalities, Drug-Induced/prevention & control
MH  - Abnormalities, Radiation-Induced/prevention & control
MH  - Abortion, Therapeutic
MH  - Adult
MH  - Antineoplastic Agents/adverse effects/therapeutic use
MH  - Breast Feeding
MH  - Contraception
MH  - Contraindications
MH  - Diagnostic Imaging/adverse effects/methods
MH  - Disease Management
MH  - Female
MH  - Fetus/drug effects/radiation effects
MH  - Humans
MH  - Incidence
MH  - Infant, Newborn
MH  - Lung Neoplasms/*diagnosis/epidemiology/*therapy
MH  - Maternal Age
MH  - Maternal-Fetal Exchange
MH  - Neoplasms/congenital
MH  - Neoplastic Cells, Circulating
MH  - Pregnancy
MH  - Pregnancy Complications, Neoplastic/*diagnosis/epidemiology/*therapy
MH  - Pregnancy Outcome
MH  - Prognosis
MH  - Radiotherapy/adverse effects
MH  - Risk Factors
MH  - Smoking/adverse effects/epidemiology
EDAT- 2013/02/20 06:00
MHDA- 2013/08/06 06:00
CRDT- 2013/02/20 06:00
PHST- 2012/03/19 00:00 [received]
PHST- 2012/10/18 00:00 [accepted]
PHST- 2013/02/20 06:00 [entrez]
PHST- 2013/02/20 06:00 [pubmed]
PHST- 2013/08/06 06:00 [medline]
AID - S0761-8425(12)01003-0 [pii]
AID - 10.1016/j.rmr.2012.11.003 [doi]
PST - ppublish
SO  - Rev Mal Respir. 2013 Feb;30(2):125-36. doi: 10.1016/j.rmr.2012.11.003. Epub 2012 
      Dec 31.


PMID- 23418868
OWN - NLM
STAT- MEDLINE
DCOM- 20140421
LR  - 20151119
IS  - 2042-7174 (Electronic)
IS  - 0961-7671 (Linking)
VI  - 21
IP  - 2
DP  - 2013 Apr
TI  - Utilization patterns of antiepileptic drugs among adult epileptic patients at a
      tertiary hospital in Oman.
PG  - 117-22
LID - 10.1111/j.2042-7174.2012.00240.x [doi]
AB  - OBJECTIVES: To describe utilization patterns of antiepileptic drugs (AEDs) among 
      adult epileptic patients at a tertiary hospital in Oman. METHODS: Data were
      collected retrospectively from January 2006 to December 2009. The study included 
      all adult (>18 years) epileptic patients on AEDs and followed up at a neurology
      clinic at Sultan Qaboos University Hospital in Oman. All reported therapeutic
      drug monitoring (TDM) requests for serum AED concentrations were also collected. 
      Institutional ethical approval was sought and obtained. KEY FINDINGS: The study
      included a total of 372 patients with a mean age of 34 +/- 15 years. Monotherapy 
      AEDs accounted for 53% of the prescriptions, whereas polytherapy with two or
      three AED combinations accounted for 27% and 20% respectively. The most
      frequently prescribed AED was sodium valproate (27%) followed by carbamazepine
      (23%). The commonly prescribed AED combinations were sodium valproate with
      clonazepam (12%) followed by sodium valproate with lamotrigine (12%). Evaluation 
      of 574 TDM requests for three AEDs showed that 57% of carbamazepine, 78% of
      phenytoin and 54% of valproic acid requests were either above or below the
      recommended therapeutic threshold. Most of these requests were ordered from the
      hospital's emergency department for suspected insufficient serum concentrations. 
      CONCLUSIONS: Antiepileptic drug monotherapy is still the most frequently employed
      therapeutic strategy in adult patients with epilepsy in keeping with the standard
      therapeutic guidelines. Sodium valproate is commonly used for different types of 
      seizures reflecting its wide spectrum of anticonvulsant potential. Newer AED
      utilizations are becoming increasingly popular in our subjects particularly as
      add-on with other standard AEDs.
CI  - (c) 2012 The Authors. IJPP (c) 2012 Royal Pharmaceutical Society.
FAU - Al Za'abi, Mohammed
AU  - Al Za'abi M
AD  - Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health 
      Sciences, Sultan Qaboos University, Al Khoud, Sultanate of Oman. zaabi@squ.edu.om
FAU - Ahmed, Rowayda
AU  - Ahmed R
FAU - Al Asmi, Abdullah
AU  - Al Asmi A
FAU - Al-Zakwani, Ibrahim
AU  - Al-Zakwani I
LA  - eng
PT  - Journal Article
DEP - 20120827
PL  - England
TA  - Int J Pharm Pract
JT  - The International journal of pharmacy practice
JID - 9204243
RN  - 0 (Anticonvulsants)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anticonvulsants/blood/*therapeutic use
MH  - Drug Monitoring
MH  - Drug Therapy, Combination
MH  - Epilepsy/blood/*drug therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oman
MH  - *Practice Patterns, Physicians'
MH  - Tertiary Care Centers
EDAT- 2013/02/20 06:00
MHDA- 2014/04/22 06:00
CRDT- 2013/02/20 06:00
PHST- 2011/08/26 00:00 [received]
PHST- 2012/06/18 00:00 [accepted]
PHST- 2013/02/20 06:00 [entrez]
PHST- 2013/02/20 06:00 [pubmed]
PHST- 2014/04/22 06:00 [medline]
AID - 10.1111/j.2042-7174.2012.00240.x [doi]
PST - ppublish
SO  - Int J Pharm Pract. 2013 Apr;21(2):117-22. doi: 10.1111/j.2042-7174.2012.00240.x. 
      Epub 2012 Aug 27.


PMID- 23416630
OWN - NLM
STAT- MEDLINE
DCOM- 20130812
LR  - 20151119
IS  - 1552-7468 (Electronic)
IS  - 1527-1544 (Linking)
VI  - 13
IP  - 3
DP  - 2012 Aug
TI  - The Physician Payments Sunshine Act and the unaddressed role of nurses: an
      interest group analysis.
PG  - 154-61
LID - 10.1177/1527154412465196 [doi]
AB  - Clinician-industry relationships have risen on the policy agenda due to their
      associated economic and ethical costs. The Physician Payments Sunshine Act (PPSA)
      is the first federal legislation that aims to mitigate these costs through
      mandating disclosure of these relationships. Interest group lobbying theory is
      used to show how stakeholders have responded to scrutiny, first through
      self-regulation and then, progressively, through contributing to legislation
      development. Limitations of the PPSA include the notable omission of nurses and
      allied health professionals, making it unlikely the PPSA will be effective in
      mitigating these costs. However, it is symbolic as it marks a departure from the 
      traditional reliance on self-regulation on part of industry and the medical
      profession.
FAU - Grundy, Quinn
AU  - Grundy Q
AD  - University of California, San Francisco, San Francisco, CA 94143-0612, USA.
      quinn.grundy@ucsf.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Policy Polit Nurs Pract
JT  - Policy, politics & nursing practice
JID - 100901316
SB  - IM
MH  - Conflict of Interest/*legislation & jurisprudence
MH  - Drug Industry/ethics/*legislation & jurisprudence
MH  - Gift Giving/*ethics
MH  - Humans
MH  - Interprofessional Relations
MH  - Needs Assessment
MH  - Nurse's Role
MH  - Practice Patterns, Physicians'/economics/*legislation & jurisprudence
MH  - Public Opinion
MH  - United States
EDAT- 2013/02/19 06:00
MHDA- 2013/08/13 06:00
CRDT- 2013/02/19 06:00
PHST- 2013/02/19 06:00 [entrez]
PHST- 2013/02/19 06:00 [pubmed]
PHST- 2013/08/13 06:00 [medline]
AID - 13/3/154 [pii]
AID - 10.1177/1527154412465196 [doi]
PST - ppublish
SO  - Policy Polit Nurs Pract. 2012 Aug;13(3):154-61. doi: 10.1177/1527154412465196.


PMID- 23413935
OWN - NLM
STAT- MEDLINE
DCOM- 20131118
LR  - 20181202
IS  - 2047-3095 (Electronic)
IS  - 2047-3087 (Linking)
VI  - 24
IP  - 1
DP  - 2013 Feb
TI  - An integrated, ethically driven environmental model of clinical decision making
      in emergency settings.
PG  - 49-53
LID - 10.1111/j.2047-3095.2012.01229.x [doi]
AB  - PURPOSE: To explore the relationship between multiple variables within a model of
      critical thinking and moral reasoning. METHODS: A quantitative descriptive
      correlational design using a purposive sample of 200 emergency nurses. Measured
      variables were accuracy in clinical decision-making, moral reasoning, perceived
      care environment, and demographics. Analysis was by bivariate correlation using
      Pearson's product-moment correlation coefficients, chi square and multiple linear
      regression analysis. FINDINGS: The elements as identified in the integrated
      ethically-driven environmental model of clinical decision-making (IEDEM-CD)
      corrected depict moral reasoning and environment of care as factors significantly
      affecting accuracy in decision-making. CONCLUSIONS: The integrated, ethically
      driven environmental model of clinical decision making is a framework useful for 
      predicting clinical decision making accuracy for emergency nurses in practice,
      with further implications in education, research and policy. PRACTICE
      IMPLICATIONS: A diagnostic and therapeutic framework for identifying and
      remediating individual and environmental challenges to accurate clinical decision
      making.
CI  - (c) 2012, The Author. International Journal of Nursing Knowledge (c) 2012, NANDA 
      International.
FAU - Wolf, Lisa
AU  - Wolf L
AD  - University of Massachusetts, Amherst.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121016
PL  - United States
TA  - Int J Nurs Knowl
JT  - International journal of nursing knowledge
JID - 101582422
MH  - Adult
MH  - Aged
MH  - *Decision Making
MH  - *Emergency Nursing
MH  - *Ethics, Nursing
MH  - Humans
MH  - Middle Aged
MH  - *Models, Nursing
MH  - Nursing Staff, Hospital/*psychology
MH  - Workforce
EDAT- 2013/02/19 06:00
MHDA- 2013/11/19 06:00
CRDT- 2013/02/19 06:00
PHST- 2013/02/19 06:00 [entrez]
PHST- 2013/02/19 06:00 [pubmed]
PHST- 2013/11/19 06:00 [medline]
AID - 10.1111/j.2047-3095.2012.01229.x [doi]
PST - ppublish
SO  - Int J Nurs Knowl. 2013 Feb;24(1):49-53. doi: 10.1111/j.2047-3095.2012.01229.x.
      Epub 2012 Oct 16.


PMID- 23413608
OWN - NLM
STAT- MEDLINE
DCOM- 20130305
LR  - 20151119
IS  - 0890-9091 (Print)
IS  - 0890-9091 (Linking)
VI  - 26
IP  - 12
DP  - 2012 Dec
TI  - Ethics of cost containment for cancer therapies: will the Affordable Care Act
      bring down costs?
PG  - 1227-9
FAU - Caplan, Arthur
AU  - Caplan A
LA  - eng
PT  - Interview
PL  - United States
TA  - Oncology (Williston Park)
JT  - Oncology (Williston Park, N.Y.)
JID - 8712059
SB  - IM
MH  - Attitude of Health Personnel
MH  - Cost Control
MH  - Evidence-Based Medicine/economics/ethics
MH  - Guideline Adherence
MH  - Health Care Costs/*ethics
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Medical Oncology/*economics/*ethics
MH  - Patient Protection and Affordable Care Act/*economics/*ethics
MH  - Practice Guidelines as Topic
MH  - Practice Patterns, Physicians'/economics/ethics
MH  - Quality of Health Care/*economics/*ethics
MH  - United States
EDAT- 2013/02/19 06:00
MHDA- 2013/03/06 06:00
CRDT- 2013/02/19 06:00
PHST- 2013/02/19 06:00 [entrez]
PHST- 2013/02/19 06:00 [pubmed]
PHST- 2013/03/06 06:00 [medline]
PST - ppublish
SO  - Oncology (Williston Park). 2012 Dec;26(12):1227-9.


PMID- 23410036
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160820
LR  - 20160817
IS  - 0966-0429 (Print)
IS  - 0966-0429 (Linking)
VI  - 22
IP  - 1
DP  - 2014 Jan
TI  - Simulations in nursing practice: toward authentic leadership.
PG  - 60-9
LID - 10.1111/j.1365-2834.2012.01426.x [doi]
AB  - Aim This study explores nurses' ethical decision-making in team simulations in
      order to identify the benefits of these simulations for authentic leadership.
      Background While previous studies have indicated that team simulations may
      improve ethics in the workplace by reducing the number of errors, those studies
      focused mainly on clinical aspects and not on nurses' ethical experiences or on
      the benefits of authentic leadership. Methods Fifty nurses from 10 health
      institutions in central Israel participated in the study. Data about nurses'
      ethical experiences were collected from 10 teams. Qualitative data analysis based
      on Grounded Theory was applied, using the atlas.ti 5.0 software package. Findings
      Simulation findings suggest four main benefits that reflect the underlying
      components of authentic leadership: self-awareness, relational transparency,
      balanced information processing and internalized moral perspective. Conclusions
      Team-based simulation as a training tool may lead to authentic leadership among
      nurses. Implications for nursing management Nursing management should incorporate
      team simulations into nursing practice to help resolve power conflicts and to
      develop authentic leadership in nursing. Consequently, errors will decrease,
      patients' safety will increase and optimal treatment will be provided.
CI  - (c) 2012 John Wiley & Sons Ltd.
FAU - Shapira-Lishchinsky, Orly
AU  - Shapira-Lishchinsky O
AD  - Faculty Member, Department of Educational Administration, Leadership and Policy, 
      School of Education, Bar-Ilan University, Ramat-Gan, Israel.
LA  - eng
PT  - Journal Article
DEP - 20120609
PL  - England
TA  - J Nurs Manag
JT  - Journal of nursing management
JID - 9306050
OTO - NOTNLM
OT  - authentic leadership
OT  - ethical dilemmas
OT  - health care
OT  - nursing
OT  - team-based-simulation
EDAT- 2013/02/16 06:00
MHDA- 2013/02/16 06:01
CRDT- 2013/02/16 06:00
PHST- 2013/02/16 06:00 [entrez]
PHST- 2013/02/16 06:00 [pubmed]
PHST- 2013/02/16 06:01 [medline]
AID - 10.1111/j.1365-2834.2012.01426.x [doi]
PST - ppublish
SO  - J Nurs Manag. 2014 Jan;22(1):60-9. doi: 10.1111/j.1365-2834.2012.01426.x. Epub
      2012 Jun 9.


PMID- 23409869
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160820
LR  - 20160817
IS  - 0966-0429 (Print)
IS  - 0966-0429 (Linking)
VI  - 22
IP  - 1
DP  - 2014 Jan
TI  - Nurse leaders' responsibilities in supporting nurses experiencing difficult
      situations in clinical nursing.
PG  - 117-26
LID - 10.1111/j.1365-2834.2012.01468.x [doi]
AB  - AIM: To make nurse leaders aware of different kinds of difficult situations in
      clinical nursing that may cause suffering to nurses and to discuss how nurse
      leaders can approach and alleviate this suffering. BACKGROUND: Difficult
      situations are a part of clinical nursing. Nurses are repeatedly exposed to
      situations that may cause them suffering and reduce their ability to serve the
      patients. METHOD: Data collection was based on a sample of semi-structured
      face-to-face deep interviews with eight nurses who were encouraged to narrate
      their lived experiences of difficult situations in clinical nursing. RESULTS:
      Nurses want to discuss issues connected to nursing and caring science that emerge
      in clinical nursing with their nurse leaders. Painful memories and thoughts are
      often related to patients struggling between life and death, the despair of
      families and friends, and their hovering between hope and hopelessness. The
      results do not support the notion that nurses would request other kinds of
      support or debriefing. CONCLUSIONS: The mission of nursing is to serve, console
      and alleviate human suffering. Nurse leaders carry a responsibility to create
      such evidence-based caring cultures that support the mission of nursing. Nurse
      leaders' understanding, sympathetic attitude, ethical value basis, personality
      and ability to discuss are important aspects for nurses. Through the support from
      nurse leaders, it seems possible to alleviate the nurse's suffering in clinical
      nursing. Implications for Nursing Management Nurse leaders' support creates a
      foundation for the nurses' professional development.
CI  - (c) 2012 John Wiley & Sons Ltd.
FAU - Honkavuo, Leena
AU  - Honkavuo L
AD  - Division for Social Sciences, Department of Caring Science, University of Abo
      Akademi, Vasa, Finland.
FAU - Lindstrom, Unni A
AU  - Lindstrom UA
AD  - Division for Social Sciences, Department of Caring Science, University of Abo
      Akademi, Vasa, Finland.
LA  - eng
PT  - Journal Article
DEP - 20121102
PL  - England
TA  - J Nurs Manag
JT  - Journal of nursing management
JID - 9306050
OTO - NOTNLM
OT  - clinical nursing
OT  - difficult situations
OT  - nurse leader
OT  - responsibility
OT  - suffering
OT  - support
EDAT- 2013/02/16 06:00
MHDA- 2013/02/16 06:01
CRDT- 2013/02/16 06:00
PHST- 2012/06/18 00:00 [accepted]
PHST- 2013/02/16 06:00 [entrez]
PHST- 2013/02/16 06:00 [pubmed]
PHST- 2013/02/16 06:01 [medline]
AID - 10.1111/j.1365-2834.2012.01468.x [doi]
PST - ppublish
SO  - J Nurs Manag. 2014 Jan;22(1):117-26. doi: 10.1111/j.1365-2834.2012.01468.x. Epub 
      2012 Nov 2.


PMID- 23409611
OWN - NLM
STAT- MEDLINE
DCOM- 20130319
LR  - 20191112
IS  - 0360-1293 (Print)
IS  - 0360-1293 (Linking)
VI  - 37
IP  - 4
DP  - 2012
TI  - The effects of acupuncture on the levels of blood pressure and nitric oxide in
      hypertensive patients.
PG  - 263-75
AB  - Hypertension possess a significant risk factor for a variety of diseases and
      affects millions of people all around the world. Recent studies suggest that NO
      plays a role in pathogenesis of hypertension while some investigators find a
      close relationship between acupuncture treatment and NO levels. We therefore
      aimed to investigate the effect of acupuncture on the levels of blood pressure
      and nitric oxide (NO) in hypertensive patients. After obtaining institutional
      ethics committee approval and patients' informed consent, 32 essential
      hypertensive patients aged between 32-65 and taking antihypertensive drugs were
      included to the study. A total of 10 sessions of manual acupuncture were applied 
      on body acupoints (EX-HN3 (Yintang), KI 3, LIV 3, SP 9, LI 4, HT 7, ST 36, SP 6) 
      in 10 weeks. Systolic (SBP) and diastolic blood pressure (DBP) levels and blood
      NO levels were measured for 3 times (i.e. before & after the first session, and
      after the 10th session). Main outcome measures of our study were the changes in
      SBP and DBP as well as nitric oxide levels between 3 measurements were compared. 
      Our study showed that SBP and DBP values decreased both after the 1st and 10th
      sessions of acupuncture treatments (p<0.05). The NO concentration also increased 
      both after the 1st (71.5%) and 10th sessions (184.6%) (p<0.05).
FAU - Severcan, Cinar
AU  - Severcan C
AD  - Dept. of Biochemistry, Gazi University Medical School, Ankara, Turkey.
FAU - Cevik, Cemal
AU  - Cevik C
FAU - Acar, H Volkan
AU  - Acar HV
FAU - Sivri, Ayse Banu Cayci
AU  - Sivri AB
FAU - Mit, S Setenay
AU  - Mit SS
FAU - Gecioglu, Ersel
AU  - Gecioglu E
FAU - Pasaoglu, Ozge Tugce
AU  - Pasaoglu OT
FAU - Gunduztepe, Yasemin
AU  - Gunduztepe Y
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Acupunct Electrother Res
JT  - Acupuncture & electro-therapeutics research
JID - 7610364
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - IM
MH  - Acupuncture Points
MH  - *Acupuncture Therapy
MH  - Adult
MH  - Aged
MH  - Blood Pressure
MH  - Female
MH  - Humans
MH  - Hypertension/blood/*physiopathology/*therapy
MH  - Male
MH  - Middle Aged
MH  - Nitric Oxide/*blood
MH  - Treatment Outcome
EDAT- 2013/02/16 06:00
MHDA- 2013/03/21 06:00
CRDT- 2013/02/16 06:00
PHST- 2013/02/16 06:00 [entrez]
PHST- 2013/02/16 06:00 [pubmed]
PHST- 2013/03/21 06:00 [medline]
AID - 10.3727/036012912x13831831256320 [doi]
PST - ppublish
SO  - Acupunct Electrother Res. 2012;37(4):263-75. doi:
      10.3727/036012912x13831831256320.


PMID- 23409538
OWN - NLM
STAT- MEDLINE
DCOM- 20130402
LR  - 20191112
IS  - 1321-2753 (Print)
IS  - 1321-2753 (Linking)
VI  - 30
IP  - 2
DP  - 2012 Sep
TI  - Ethical expertise and Human Research Ethics Committees (HRECs).
PG  - 81-101
FAU - Douglas, Peter
AU  - Douglas P
AD  - Centre for Human Bioethics, Monash University. peter.douglas@monash.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Monash Bioeth Rev
JT  - Monash bioethics review
JID - 100973394
SB  - IM
MH  - Australia
MH  - Credentialing
MH  - *Ethical Review
MH  - Ethical Theory
MH  - *Ethicists
MH  - *Ethics Committees, Research
MH  - Humans
MH  - Inservice Training
MH  - *Professional Competence
EDAT- 2013/02/16 06:00
MHDA- 2013/04/03 06:00
CRDT- 2013/02/16 06:00
PHST- 2013/02/16 06:00 [entrez]
PHST- 2013/02/16 06:00 [pubmed]
PHST- 2013/04/03 06:00 [medline]
AID - 10.1007/BF03351341 [doi]
PST - ppublish
SO  - Monash Bioeth Rev. 2012 Sep;30(2):81-101. doi: 10.1007/BF03351341.


PMID- 23409537
OWN - NLM
STAT- MEDLINE
DCOM- 20130402
LR  - 20191112
IS  - 1321-2753 (Print)
IS  - 1321-2753 (Linking)
VI  - 30
IP  - 2
DP  - 2012 Sep
TI  - Ethical questions arising from counselling in fetal complex congenital heart
      disease.
PG  - 62-7
AB  - Fetal ultrasounds are almost routinely carried out during pregnancies in Western 
      society. It has led to the in-utero diagnosis of congenital malformations, and in
      skilled hands, complex congenital heart disease which carries a significant
      morbidity and definite mortality. That has allowed for counselling of the
      affected parents who may have the option of whether to continue with the
      pregnancy. Such counselling, however is not without its difficulties and ethical 
      dilemmas. They range from attempting to inform at times very distressed parents, 
      the nature and implications of their fetal abnormality, the outcome and risks
      involved in the interventions which may be required, while at the same time being
      asked to prognosticate the long-term outcomes. Such counselling at times is based
      on incomplete information obtained or refers to lesions that may evolve during
      the rest of the pregnancy. In addition, the information provided is unable to
      factor in possible advances that may occur in the future which may alter the
      quality of life and outcomes of the affected individuals. Other members of the
      concerned extended family may wish to have a say in the decision making process. 
      The clinicians themselves may wish to take into account not only the burden to
      the family emotionally and in terms of the possible interventions - surgical or
      otherwise, hospitalisations, the risks of complications, and so on - but also the
      financial and other costs borne by the community. This article highlights the
      problems encountered and raises ethical questions to encourage discussion to
      guide the clinicians involved.
FAU - Menahem, Samuel
AU  - Menahem S
AD  - Fetal Cardiac Unit, Monash Medical Centre. samuel.menahem@southernhealth.org.au
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Monash Bioeth Rev
JT  - Monash bioethics review
JID - 100973394
SB  - IM
MH  - Counseling/*ethics
MH  - Decision Making/*ethics
MH  - Female
MH  - Genetic Counseling/*ethics
MH  - *Heart Defects, Congenital/diagnostic imaging
MH  - Humans
MH  - Pregnancy
MH  - Prenatal Diagnosis/*ethics
MH  - Ultrasonography
EDAT- 2013/02/16 06:00
MHDA- 2013/04/03 06:00
CRDT- 2013/02/16 06:00
PHST- 2013/02/16 06:00 [entrez]
PHST- 2013/02/16 06:00 [pubmed]
PHST- 2013/04/03 06:00 [medline]
AID - 10.1007/BF03351340 [doi]
PST - ppublish
SO  - Monash Bioeth Rev. 2012 Sep;30(2):62-7. doi: 10.1007/BF03351340.


PMID- 23409498
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20130215
IS  - 1173-2032 (Print)
IS  - 1173-2032 (Linking)
VI  - 18
IP  - 11
DP  - 2012 Dec-2013 Jan
TI  - 'No conflict between nursing ethics and helping a patient die with dignity'.
PG  - 26-7
FAU - Havill, Glynis
AU  - Havill G
FAU - Nichols, Jenny
AU  - Nichols J
LA  - eng
PT  - Journal Article
PL  - New Zealand
TA  - Nurs N Z
JT  - Nursing New Zealand (Wellington, N.Z. : 1995)
JID - 9507374
MH  - *Ethics, Nursing
MH  - Humans
MH  - New Zealand
MH  - Nursing Staff/*ethics
MH  - Palliative Care/*ethics
MH  - Right to Die/*ethics
EDAT- 2013/02/16 06:00
MHDA- 2013/03/13 06:00
CRDT- 2013/02/16 06:00
PHST- 2013/02/16 06:00 [entrez]
PHST- 2013/02/16 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
PST - ppublish
SO  - Nurs N Z. 2012 Dec-2013 Jan;18(11):26-7.


PMID- 23407588
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130215
LR  - 20220310
IS  - 2008-2835 (Print)
IS  - 2008-2835 (Linking)
VI  - 4
IP  - 3
DP  - 2012 Jul
TI  - Regulations and ethical considerations in animal experiments: international laws 
      and islamic perspectives.
PG  - 114-20
AB  - Growing usage of animals in the research projects has drawn more attention to
      their welfare and ethics surrounding this practice. Dissemination of information 
      about the existing ethical consideration and alternatives in animal experiments
      has two important functions; first, it increases the researcher's awareness of
      the possible methods of using animals in the experiment, and second, to ensure
      that potential users are aware of the established alternatives. For example,
      legislations enacted in many countries during the 1980s state that laboratory
      animal applications should be reduced, refined and replaced wherever possible
      according to principles of the 3Rs. Thus, scientists around the world tried to
      apply the 3Rs in their biomedical researches regarding welfare of the laboratory 
      animals. However, the Qur'an, the holy book of Muslims, and also Hadiths contain 
      the obligatory ways to keep and treat animals since their revelations. According 
      to Islamic viewpoint, animals represent Allah's ability and wisdom, and humans
      must pay attention to their health and living conditions. Several Islamic
      manuscripts state that animals have their own position in the creation hierarchy 
      and humans are responsible for supplying minimal facilities and their welfare.
      This paper has tried to review ethical consideration in animal experiments and
      regarding Islamic resources in this case to encourage providing comprehensive
      ethical regulations in animal experiments which its establishment could be
      beneficial for animal ethics committees or research institutes.
FAU - Naderi, Mohammad Mehdi
AU  - Naderi MM
AD  - Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR,
      Tehran, Iran ; These authors equally contribute to this work.
FAU - Sarvari, Ali
AU  - Sarvari A
FAU - Milanifar, Alireza
AU  - Milanifar A
FAU - Boroujeni, Sara Borjian
AU  - Boroujeni SB
FAU - Akhondi, Mohammad Mehdi
AU  - Akhondi MM
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Avicenna J Med Biotechnol
JT  - Avicenna journal of medical biotechnology
JID - 101511065
PMC - PMC3558218
OTO - NOTNLM
OT  - Animals
OT  - Ethics
OT  - Research
OT  - Welfare
EDAT- 2013/02/15 06:00
MHDA- 2013/02/15 06:01
CRDT- 2013/02/15 06:00
PHST- 2012/02/20 00:00 [received]
PHST- 2012/05/14 00:00 [accepted]
PHST- 2013/02/15 06:00 [entrez]
PHST- 2013/02/15 06:00 [pubmed]
PHST- 2013/02/15 06:01 [medline]
PST - ppublish
SO  - Avicenna J Med Biotechnol. 2012 Jul;4(3):114-20.


PMID- 23406200
OWN - NLM
STAT- MEDLINE
DCOM- 20140213
LR  - 20220409
IS  - 1365-2834 (Electronic)
IS  - 0966-0429 (Linking)
VI  - 21
IP  - 3
DP  - 2013 Apr
TI  - The influence of authentic leadership and areas of worklife on work engagement of
      registered nurses.
PG  - 529-40
LID - 10.1111/j.1365-2834.2012.01399.x [doi]
AB  - AIM: To examine the relationships among nurses' perceptions of nurse managers'
      authentic leadership, nurses' overall person-job match in the six areas of
      worklife and their work engagement. BACKGROUND: Reports have highlighted the
      impact of demanding and unsupportive work environments on nurses' wellbeing,
      resulting in a need for strong nursing leadership to build sustainable and
      healthier work environments. METHODS: A secondary analysis of data collected from
      a non-experimental, predictive design survey of a random sample of 280 registered
      nurses working in acute care hospitals was conducted. RESULTS: An overall
      person-job match in the six areas of worklife fully mediated the relationship
      between authentic leadership and work engagement. Further, authentic leadership, 
      overall person-job match in the six areas of worklife and years of nursing
      experience explained 33.1% of the variance in work engagement. CONCLUSIONS:
      Findings suggest that nurses who work for managers demonstrating higher levels of
      authentic leadership report a greater overall person-job match in the six areas
      of worklife and greater work engagement. IMPLICATIONS FOR NURSING MANAGEMENT: As 
      nurse managers' play a key role in promoting work engagement among nurses,
      authentic leadership development for nurse managers focusing on self-awareness,
      relational transparency, ethics and balanced processing would be beneficial.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Bamford, Megan
AU  - Bamford M
AD  - South West Community Care Access Centre, London, Ontario, Canada.
FAU - Wong, Carol A
AU  - Wong CA
FAU - Laschinger, Heather
AU  - Laschinger H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120426
PL  - England
TA  - J Nurs Manag
JT  - Journal of nursing management
JID - 9306050
MH  - Female
MH  - Humans
MH  - Job Satisfaction
MH  - *Leadership
MH  - Male
MH  - Negotiating
MH  - *Nurse Administrators/organization & administration/standards
MH  - Organizational Culture
MH  - *Power, Psychological
MH  - Workload
MH  - Workplace/psychology
EDAT- 2013/02/15 06:00
MHDA- 2014/02/14 06:00
CRDT- 2013/02/15 06:00
PHST- 2013/02/15 06:00 [entrez]
PHST- 2013/02/15 06:00 [pubmed]
PHST- 2014/02/14 06:00 [medline]
AID - 10.1111/j.1365-2834.2012.01399.x [doi]
PST - ppublish
SO  - J Nurs Manag. 2013 Apr;21(3):529-40. doi: 10.1111/j.1365-2834.2012.01399.x. Epub 
      2012 Apr 26.


PMID- 23404020
OWN - NLM
STAT- MEDLINE
DCOM- 20130823
LR  - 20191027
IS  - 1526-3711 (Electronic)
IS  - 1526-3711 (Linking)
VI  - 13
IP  - 6
DP  - 2012 Nov 1
TI  - Managing HIV/hepatitis positive patients: present approach of dental health care 
      workers and students.
PG  - 882-5
AB  - People with HIV/HBsAg in India frequently encounter discrimination while seeking 
      and receiving health care services. The knowledge and attitudes of health care
      workers (HCWs) influences the willingness and ability of people with HIV/HBsAg to
      access care, and the quality of the care they receive. The objective of this
      study was to asses HIV/HBsAg-related knowledge, attitudes and risk perception
      among students and dental HCWs. A cross-sectional survey was conducted on 250
      students and 120 dental HCWs in the form of objective questionnaire. Information 
      was gathered regarding demographic details (age, sex, duration of employment, job
      category); HIV/ HBsAg-related knowledge and attitudes; risk perception; and
      previous experience caring for HIV-positive patients. The HCWs in this study
      generally had a positive attitude to care for the people with HIV/HBsAg. However,
      this was tempered by substantial concerns about providing care, and the fear of
      occupational infection with HIV/HBsAg. A continuing dental education program was 
      conducted to resolve all the queries found interfering to provide care to
      HIV/HBsAg patients. But even after the queries were resolved the care providing
      capability was not attained. These findings show that even with advanced
      knowledge and facilities the attitude of dental HCWs and students require more
      strategic training with regards to the ethics and moral stigma associated with
      the dreaded infectious diseases (HIV/HBsAg).
FAU - Shinde, Nagesh
AU  - Shinde N
AD  - Department of Oral and Maxillofacial Pathology, ACPM Dental College and Hospital,
      Dhule, Maharashtra, India. drnshinde@indiatimes.com
FAU - Baad, Rajendra
AU  - Baad R
FAU - Nagpal, Deepak Kumar J
AU  - Nagpal DK
FAU - Prabhu, Prashant R
AU  - Prabhu PR
FAU - Surekha, L Chavan
AU  - Surekha LC
FAU - Karande, Prasad
AU  - Karande P
LA  - eng
PT  - Journal Article
DEP - 20121101
PL  - India
TA  - J Contemp Dent Pract
JT  - The journal of contemporary dental practice
JID - 101090552
RN  - 0 (Hepatitis B Surface Antigens)
SB  - IM
MH  - Age Factors
MH  - *Attitude of Health Personnel
MH  - Cross-Sectional Studies
MH  - Dental Auxiliaries/ethics/*psychology
MH  - *Dental Care for Chronically Ill/ethics
MH  - Dentists/ethics/*psychology
MH  - Education, Dental
MH  - Employment
MH  - Ethics, Dental
MH  - Fear/psychology
MH  - Female
MH  - HIV Infections/transmission
MH  - *HIV Seropositivity/psychology
MH  - Health Knowledge, Attitudes, Practice
MH  - *Hepatitis B/psychology/transmission
MH  - Hepatitis B Surface Antigens/blood
MH  - Humans
MH  - India
MH  - Male
MH  - Occupational Diseases/etiology
MH  - Prejudice
MH  - Risk Assessment
MH  - Social Stigma
MH  - Students, Dental/*psychology
MH  - Surveys and Questionnaires
EDAT- 2013/02/14 06:00
MHDA- 2013/08/24 06:00
CRDT- 2013/02/14 06:00
PHST- 2013/02/14 06:00 [entrez]
PHST- 2013/02/14 06:00 [pubmed]
PHST- 2013/08/24 06:00 [medline]
AID - 1526-3711-984 [pii]
AID - 10.5005/jp-journals-10024-1246 [doi]
PST - epublish
SO  - J Contemp Dent Pract. 2012 Nov 1;13(6):882-5. doi:
      10.5005/jp-journals-10024-1246.


PMID- 23399754
OWN - NLM
STAT- MEDLINE
DCOM- 20140929
LR  - 20130212
IS  - 1105-2333 (Print)
IS  - 1105-2333 (Linking)
VI  - 23
IP  - 4
DP  - 2012 Oct-Dec
TI  - [Use of informatics technology in psychiatry].
PG  - 322-33
AB  - Computer technology dominates our daily lives and has become an integral
      professional tool in medical practice and by extension, in psychiatry as well.
      The widespread use of internet technology has taken place with unprecedented
      speed in the history of human civilization, spreading in a few decades to all
      countries of the world, offering novel possibilities for transmitting
      information, and leading to the globalization of knowledge. However, the speed
      with which computer technology is becoming a part of our lives is accompanied by 
      difficulties in integration. The continued evolution of applications often leads 
      to the impression that to be modern and efficient we have to run continuously
      after developments, dedicating time and effort that we cannot often afford. At
      the same time, its widespread use alters the needs of our patients, and our
      efficiency is constantly judged in a globalized environment which, while offering
      new possibilities, also has new demands. The initial impression that computer
      technology is simply a tool that can facilitate the work of those who are willing
      and able to use it has been replaced by the perception that the practice of
      medicine, in both clinical and academic level, requires sufficient knowledge of
      modern technology and the development of relevant skills for ongoing training and
      following innovative applications. The result of this assumption is the
      introduction of technology courses in the curricula of medical schools in the
      country. This article offers a brief description of the uses of information
      technology in psychiatry. In particular, e-mail is one of the most popular
      Internet services and there is internationally an increasing pressure from the
      public to be able to contact their doctor by e-mail. Furthermore, almost all
      psychiatric journals now have a digital electronic edition, thus increasing the
      volume of articles published, the ease of accessing the required information, and
      ultimately the reduction of the time it takes a psychiatrist to come to possess a
      specialized field of knowledge. The Internet also enables psychiatrists, while
      being at their residence and from their offices and homes in remote areas of a
      country, or from developing countries to be able to take part relatively easily
      in continuing medical education programs that are under development in advanced
      educational centers, eliminating in this way the barrier of distance.
      Furthermore, telemedicine allows access in health-care to people living in
      geographically isolated areas with poor medical facilities. The electronic filing
      systems on the other hand, are also expected in the near future to provide the
      essential foundation of sharing and managing information material in health care.
      Apart from the uses of technology in the practice of psychiatry, technology has
      many uses in Psychiatric Education, providing valuable assistance to both
      trainees and trainers. Today the educational community has at its disposal a
      range of devices, operating systems, and web applications useful in medical
      education. For example, we can mention the existence of technological tools for
      educational administration and management, evaluation of educational work, tools 
      for creating educational content, and learning outside the confines of the
      classroom. Developments arising from the use of technology are rapid, and its use
      brings new applications that have the potential to alter the framework of
      practicing medicine. However, in many cases, these applications do not go along
      with the guidelines and principles available to doctors in order to practice
      their profession in a manner not inconsistent with moral imperatives. The
      challenge of this new environment is to establish guidelines consistent with the 
      principles of medical ethics.
FAU - Margariti, M
AU  - Margariti M
AD  - 1st Psychiatric Clinic, University of Athens, Athens, Greece.
FAU - Papadimitriou, G N
AU  - Papadimitriou GN
LA  - gre
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Greece
TA  - Psychiatriki
JT  - Psychiatrike = Psychiatriki
JID - 101534363
SB  - IM
MH  - Education, Medical/trends
MH  - Electronic Mail
MH  - Guidelines as Topic
MH  - Humans
MH  - Informatics/methods/*trends
MH  - Internet
MH  - Psychiatry/education/methods/*trends
EDAT- 2013/02/13 06:00
MHDA- 2014/09/30 06:00
CRDT- 2013/02/13 06:00
PHST- 2013/02/13 06:00 [entrez]
PHST- 2013/02/13 06:00 [pubmed]
PHST- 2014/09/30 06:00 [medline]
PST - ppublish
SO  - Psychiatriki. 2012 Oct-Dec;23(4):322-33.


PMID- 23399088
OWN - NLM
STAT- MEDLINE
DCOM- 20130916
LR  - 20211203
IS  - 1752-8062 (Electronic)
IS  - 1752-8054 (Linking)
VI  - 6
IP  - 1
DP  - 2013 Feb
TI  - The establishment of research ethics consultation services (RECS): an emerging
      research resource.
PG  - 40-4
LID - 10.1111/cts.12008 [doi]
AB  - Emphasis on translational research to facilitate progression from the laboratory 
      into the community also creates a dynamic in which ethics and social policy
      questions and solutions are ever pressing. In response, academic institutions are
      creating Research Ethics Consultation Services (RECS). All Clinical Translational
      Science Award institutions were surveyed in early 2010 to determine which
      institutions have a RECS in operation and what is their composition and function.
      Of the 46 institutions surveyed, 33 (70%) have a RECS. Only 15 RECS have received
      any consult requests in the last year. Issues that are common among these
      relatively nascent services include relationships with institutional oversight
      committees, balancing requestor concerns about confidentiality with research
      integrity and human subjects protection priorities, tracking consult data and
      outcomes, and developing systems for internal evaluation. There is variability in
      how these issues are approached. It will be important to be attentive to the
      institutional context to develop an appropriate approach. Further data about the 
      issues raised by requestors and the recommendations provided are necessary to
      build a community of scholars who can navigate and resolve ethical issues
      encountered along the translational research pathway.
CI  - (c) 2012 Wiley Periodicals, Inc.
FAU - McCormick, Jennifer B
AU  - McCormick JB
AD  - Departments of Medicine and Health Sciences Research and Center for Translational
      Science Activities, Mayo Clinic, Rochester, MN, USA. mccormick.jb@mayo.edu
FAU - Sharp, Richard R
AU  - Sharp RR
FAU - Ottenberg, Abigale L
AU  - Ottenberg AL
FAU - Reider, Carson R
AU  - Reider CR
FAU - Taylor, Holly A
AU  - Taylor HA
FAU - Wilfond, Benjamin S
AU  - Wilfond BS
LA  - eng
GR  - UL1RR025005/RR/NCRR NIH HHS/United States
GR  - UL1 RR024989/RR/NCRR NIH HHS/United States
GR  - UL1 TR000090/TR/NCATS NIH HHS/United States
GR  - UL1 RR025005/RR/NCRR NIH HHS/United States
GR  - UL1 TR000439/TR/NCATS NIH HHS/United States
GR  - UL1 RR025014/RR/NCRR NIH HHS/United States
GR  - UL1 RR024150/RR/NCRR NIH HHS/United States
GR  - UL1 TR000423/TR/NCATS NIH HHS/United States
GR  - UL1RR024150/RR/NCRR NIH HHS/United States
GR  - UL1RR025014-04S1/RR/NCRR NIH HHS/United States
GR  - UL1RR025755/RR/NCRR NIH HHS/United States
GR  - UL1 TR000135/TR/NCATS NIH HHS/United States
GR  - UL1RR025014/RR/NCRR NIH HHS/United States
GR  - UL1 TR000424/TR/NCATS NIH HHS/United States
GR  - UL1RR024989/RR/NCRR NIH HHS/United States
GR  - UL1 RR025755/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20121206
PL  - United States
TA  - Clin Transl Sci
JT  - Clinical and translational science
JID - 101474067
SB  - IM
MH  - Academies and Institutes/ethics/statistics & numerical data
MH  - Communication
MH  - Confidentiality/ethics
MH  - Data Collection/statistics & numerical data
MH  - *Ethics Consultation/economics/statistics & numerical data
MH  - *Ethics, Research
MH  - Health Resources/*ethics/statistics & numerical data
MH  - Health Services Accessibility/statistics & numerical data
MH  - Humans
MH  - Translational Research, Biomedical/economics/ethics/statistics & numerical data
PMC - PMC3573851
MID - NIHMS413799
EDAT- 2013/02/13 06:00
MHDA- 2013/09/17 06:00
CRDT- 2013/02/13 06:00
PHST- 2013/02/13 06:00 [entrez]
PHST- 2013/02/13 06:00 [pubmed]
PHST- 2013/09/17 06:00 [medline]
AID - 10.1111/cts.12008 [doi]
PST - ppublish
SO  - Clin Transl Sci. 2013 Feb;6(1):40-4. doi: 10.1111/cts.12008. Epub 2012 Dec 6.


PMID- 23397921
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140611
LR  - 20130212
IS  - 1093-4510 (Print)
IS  - 1093-4510 (Linking)
VI  - 15
IP  - 4
DP  - 2012 Nov
TI  - Little Albert: A neurologically impaired child.
PG  - 302-27
LID - 10.1037/a0026720 [doi]
AB  - Evidence collected by Beck, Levinson, and Irons (2009) indicates that Albert B., 
      the "lost" infant subject of John B. Watson and Rosalie Rayner's (1920) famous
      conditioning study, was Douglas Merritte (1919-1925). Following the finding that 
      Merritte died early with hydrocephalus, questions arose as to whether Douglas's
      condition was congenital, rather than acquired in 1922, as cited on his death
      certificate. This etiology would imply that "Little Albert" was not the "healthy"
      and "normal" infant described by Watson and numerous secondary sources. Detailed 
      analyses of Watson's (1923) film footage of Albert suggested substantial
      behavioral and neurological deficits. The anomalies we observed on film of Albert
      B. are insufficiently explained by his hospital upbringing but are consistent
      with findings from newly discovered medical records of Douglas Merritte. These
      documents revealed that the infant suffered from congenital obstructive
      hydrocephalus, iatrogenic streptococcal meningitis/ventriculitis, and retinal and
      optic nerve atrophy. The medical history also indicates that Albert's sessions
      with Watson occurred during periods when Douglas's clinical course was relatively
      stable. Further inquiries found ample sources of information available to Watson 
      that would have made him aware of Douglas/Albert's medical condition at the times
      he tested the baby. Experimental ethics, Watson's legacy, and the Albert study
      are discussed in light of these new findings. (PsycINFO Database Record (c) 2012 
      APA, all rights reserved).
FAU - Fridlund, Alan J
AU  - Fridlund AJ
AD  - Department of Psychological and Brain Sciences, University of California, Santa
      Barbara.
FAU - Beck, Hall P
AU  - Beck HP
FAU - Goldie, William D
AU  - Goldie WD
FAU - Irons, Gary
AU  - Irons G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Hist Psychol
JT  - History of psychology
JID - 9808650
EDAT- 2013/02/13 06:00
MHDA- 2013/02/13 06:01
CRDT- 2013/02/13 06:00
PHST- 2013/02/13 06:00 [entrez]
PHST- 2013/02/13 06:00 [pubmed]
PHST- 2013/02/13 06:01 [medline]
AID - 2012-01974-001 [pii]
AID - 10.1037/a0026720 [doi]
PST - ppublish
SO  - Hist Psychol. 2012 Nov;15(4):302-27. doi: 10.1037/a0026720.


PMID- 23365359
OWN - NLM
STAT- MEDLINE
DCOM- 20130729
LR  - 20130131
IS  - 1525-3163 (Electronic)
IS  - 0021-8812 (Linking)
VI  - 90 Suppl 4
DP  - 2012 Dec
TI  - Prenatal gastrointestinal development in the pig and responses after preterm
      birth.
PG  - 290-8
LID - 10.2527/jas.54604 [doi]
AB  - Despite clinical research and medical advances, care of the preterm infant
      remains a clinical challenge, with the immature gastrointestinal (GI) system
      limiting the types and amounts of nutrients that can be provided enterally to
      meet energy and nutrient requirements. Progress in understanding the relationship
      between dietary inputs and the developing GI system after preterm birth has been 
      limited by ethical constraints of using preterm infants as experimental subjects 
      and a lack of relevant animal models. We review development of the GI system of
      the pig during gestation, the similarities shared with human fetuses, and the
      responses to dietary stimuli. The GI systems of pigs and humans develop early in 
      gestation, with growth and maturation accelerating during the final weeks prior
      to birth. As a consequence, deficits in GI digestive capacities are directly
      related to how early in gestation an infant or pig is delivered, thereby
      complicating attempts to provide adequate enteral nutrients for growth and
      development. Pigs differ from humans by being born with low activities of the
      brush border membrane carbohydrases necessary for hydrolysis of nonlactose
      carbohydrates. Fetuses of both species have impaired lipid digestion coinciding
      with lipid malabsorption after preterm birth. Protease activity, although
      present, may not be adequate and may limit growth potential. Undigested enteral
      inputs are available to the resident bacteria and the production of metabolites
      can influence health and nutrition. The preterm pig represents a relevant and
      translational animal model for understanding GI development and for identifying
      diet and regulatory factors that stimulate GI growth and maturation after preterm
      birth and thereby accelerate the transition from parenteral nutrition to full
      enteral nutrition.
FAU - Buddington, R K
AU  - Buddington RK
AD  - Department of Health and Sport Sciences, University of Memphis, Memphis, TN
      38117, USA. rbddngtn@memphis.edu
FAU - Sangild, P T
AU  - Sangild PT
FAU - Hance, B
AU  - Hance B
FAU - Huang, E Y
AU  - Huang EY
FAU - Black, D D
AU  - Black DD
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Anim Sci
JT  - Journal of animal science
JID - 8003002
SB  - IM
MH  - Animals
MH  - Female
MH  - Fetal Development/*physiology
MH  - Gastrointestinal Tract/*growth & development
MH  - Pregnancy
MH  - *Premature Birth
MH  - Swine/*growth & development
EDAT- 2013/02/13 06:00
MHDA- 2013/07/31 06:00
CRDT- 2013/02/01 06:00
PHST- 2013/02/01 06:00 [entrez]
PHST- 2013/02/13 06:00 [pubmed]
PHST- 2013/07/31 06:00 [medline]
AID - 90/Supplement_4/290 [pii]
AID - 10.2527/jas.54604 [doi]
PST - ppublish
SO  - J Anim Sci. 2012 Dec;90 Suppl 4:290-8. doi: 10.2527/jas.54604.


PMID- 23396796
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 2210-5433 (Print)
IS  - 2210-5433 (Linking)
VI  - 25
IP  - 4
DP  - 2012 Dec
TI  - The Right and Wrong of Growing Old: Assessing the Argument from Evolution.
PG  - 547-560
AB  - One argument which is frequently levelled against the enhancement of human
      biology is that we do not understand the evolved function of our bodies well
      enough to meddle in our biology without producing unintended and potentially
      catastrophic effects. In particular, this argument is levelled against attempts
      to slow or eliminate the processes of human ageing, or 'senescence', which cause 
      us to grow decrepit before we die. In this article, I claim that even if this
      argument could usefully be applied against attempts to enhance other human
      traits, it cannot be valid in the case of attempts to enhance the various
      processes that constitute senescence. I begin by reviewing the biology of ageing 
      to show how it consists of a number of unrelated traits. Then, following the
      arguments of a number of evolutionary biologists, I explain that every one of
      these traits is a product of evolutionary 'neglect' rather than 'intent'.
      Finally, I consider the strongest version of the argument against enhancing
      senescence, which acknowledges these facts about the evolution of ageing but
      insists that we have nevertheless have prudential reasons to avoid enhancement
      wherever there is some uncertainty about the genetics or evolutionary function of
      a trait. I provide two reasons for rejecting this version of the argument as
      well, even in the case of human senescence, where such uncertainty is currently
      significant.
FAU - Foddy, Bennett
AU  - Foddy B
AD  - Institute for Science & Ethics, University of Oxford, Suite 8, Littlegate House, 
      16-17 St. Ebbes St, Oxford, OX1 1PT UK.
LA  - eng
PT  - Journal Article
DEP - 20120228
PL  - Netherlands
TA  - Philos Technol
JT  - Philosophy & technology
JID - 101583724
PMC - PMC3566834
OTO - NOTNLM
OT  - Ageing
OT  - Ethics
OT  - Evolution
OT  - Genetics
OT  - Human enhancement
OT  - Senescence
EDAT- 2013/02/12 06:00
MHDA- 2013/02/12 06:01
CRDT- 2013/02/12 06:00
PHST- 2011/11/21 00:00 [received]
PHST- 2012/01/23 00:00 [accepted]
PHST- 2013/02/12 06:00 [entrez]
PHST- 2013/02/12 06:00 [pubmed]
PHST- 2013/02/12 06:01 [medline]
AID - 10.1007/s13347-012-0066-7 [doi]
AID - 66 [pii]
PST - ppublish
SO  - Philos Technol. 2012 Dec;25(4):547-560. doi: 10.1007/s13347-012-0066-7. Epub 2012
      Feb 28.


PMID- 23394238
OWN - NLM
STAT- MEDLINE
DCOM- 20130614
LR  - 20130211
IS  - 0009-4293 (Print)
IS  - 0009-4293 (Linking)
VI  - 66
IP  - 11
DP  - 2012
TI  - L'Eprouvette: a special place to get a flavor of research and to debate about
      research issues.
PG  - 851-2
LID - 10.2533/chimia.2012.851 [doi]
AB  - L'Eprouvette, the public laboratory of University of Lausanne, is dedicated to
      science outreach and promotion of dialogue between scientists and society. The
      laboratory provides direct access to techniques and instruments in order to
      engage in informed and critical dialogue about the social and ethical issues of
      sciences.
FAU - Ythier, Mathilde
AU  - Ythier M
AD  - University of Lausanne, Lausanne, Switzerland.
FAU - Auberson, Patricia
AU  - Auberson P
FAU - Trouilloud, Severine
AU  - Trouilloud S
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Chimia (Aarau)
JT  - Chimia
JID - 0373152
SB  - IM
MH  - Biology/education/ethics
MH  - Community-Institutional Relations
MH  - Ethics, Research
MH  - Humans
MH  - *Laboratories
MH  - Patient Education as Topic
MH  - Rare Diseases
MH  - Research/*education
MH  - Research Personnel
MH  - Students
MH  - *Universities
EDAT- 2013/02/12 06:00
MHDA- 2013/06/15 06:00
CRDT- 2013/02/12 06:00
PHST- 2013/02/12 06:00 [entrez]
PHST- 2013/02/12 06:00 [pubmed]
PHST- 2013/06/15 06:00 [medline]
AID - 10.2533/chimia.2012.851 [doi]
PST - ppublish
SO  - Chimia (Aarau). 2012;66(11):851-2. doi: 10.2533/chimia.2012.851.


PMID- 23393958
OWN - NLM
STAT- MEDLINE
DCOM- 20130627
LR  - 20191112
IS  - 0886-6708 (Print)
IS  - 0886-6708 (Linking)
VI  - 27
IP  - 6
DP  - 2012
TI  - Respondents' experiences of completing a retrospective web-based, sexual trauma
      survey: does a history of sexual victimization equate with risk for harm?
PG  - 991-1004
AB  - This study investigated respondents' experiences of completing a retrospective
      web-based survey exploring sexual revictimization. The original survey provided a
      link to a separate mixed-methods survey assessing the impact of participation. Of
      the original 481 respondents, 234 completed this follow-up survey. Eighty percent
      were female and 52% reported histories of sexual victimization (SV). Newman,
      Willard, Sinclair, and Kaloupek's (2001) Reactions to Research Participation
      Questionnaire was adapted to suit this web-based design, and several open-ended
      questions were included. The statistical analysis revealed that those who
      experienced SV reported higher levels of distress and personal benefit and were
      less likely to be inconvenienced by participation. However, higher levels of
      benefit did not always compensate for greater levels of distress, particularly
      for those with more recent and more extensive histories of SV. The thematic
      analysis of the qualitative responses is discussed and suggestions are offered
      for the design of more ethically sensitive research protocols and practices.
FAU - Wager, Nadia M
AU  - Wager NM
AD  - University of Bedfordshire, Department of Psychology, Faculty of Health and
      Social Science, Luton, Bedfordshire, United Kingdom. nadia.wager@beds.ac.uk
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Violence Vict
JT  - Violence and victims
JID - 8916436
SB  - IM
MH  - Adult
MH  - Aggression/psychology
MH  - Comorbidity
MH  - Crime Victims/psychology/*statistics & numerical data
MH  - Female
MH  - Humans
MH  - *Internet
MH  - Life Style
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Spouse Abuse/psychology/*statistics & numerical data
MH  - Stress Disorders, Post-Traumatic/*epidemiology/psychology
MH  - Surveys and Questionnaires
MH  - *Women's Health
MH  - Young Adult
EDAT- 2013/02/12 06:00
MHDA- 2013/06/29 06:00
CRDT- 2013/02/12 06:00
PHST- 2013/02/12 06:00 [entrez]
PHST- 2013/02/12 06:00 [pubmed]
PHST- 2013/06/29 06:00 [medline]
AID - 10.1891/0886-6708.27.6.991 [doi]
PST - ppublish
SO  - Violence Vict. 2012;27(6):991-1004. doi: 10.1891/0886-6708.27.6.991.


PMID- 23393707
OWN - NLM
STAT- MEDLINE
DCOM- 20130221
LR  - 20130211
IS  - 1565-1088 (Print)
VI  - 14
IP  - 12
DP  - 2012 Dec
TI  - Clauberg's eponym and crimes against humanity.
PG  - 719-23
AB  - Scientific journals are ethically bound to cite Professor Dr. Carl Clauberg's
      Nazi medical crimes against humanity whenever the eponym Clauberg is used. Modern
      articles still publish the eponym citing only the rabbit bioassy used in
      developing progesterone agonists or antagonists for birth control. Clauberg's
      Nazi career is traced to his having subjected thousands of Jewish women at the
      Ravensbruck and Auschwitz-Birkenau death camps to cruel, murderous sterilization 
      experiments that are enthusiastically described by incriminating letters
      (reproduced here) between him and the notorious Nazi Reichsfuhrer-SS Heinrich
      Himmler. The experiments were carried out in women's block 10 in
      Auschwitz-Birkenau where Clauberg's colleague Dr. Josef Mengele worked alongside.
      After Germany lost World War II in 1945 Mengele fled to South America, where he
      lived to an old age. Clauberg was caught by Russian soldiers, put on trial in the
      Soviet Union for his crimes against humanity, and imprisoned in 1948. In 1955 he 
      was repatriated to Germany, once again imprisoned for his crimes, and belatedly
      expelled from the German Medical Association. To estimate the contemporary usage 
      of the names Mengele and Clauberg, Internet hits were recorded for Clauberg C or 
      Mengele J (with and without adding the term Auschwitz) with the Google and Scirus
      search engines. The ratios of hits for combinations of these terms reveal that
      relative to Mengele, Clauberg's name is barely known. We propose that journals
      and books printing the eponym Clauberg cite its derivation and reference to the
      convicted Nazi criminal. The present article can serve for such citations.
FAU - Sweet, Frederick
AU  - Sweet F
AD  - Department of Obstetrics and Gynecology, Washington University School of
      Medicine, St. Louis, MO 63110, USA. sweetf@wustl.edu
FAU - Csapo-Sweet, Rita M
AU  - Csapo-Sweet RM
LA  - eng
PT  - Biography
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Israel
TA  - Isr Med Assoc J
JT  - The Israel Medical Association journal : IMAJ
JID - 100930740
SB  - IM
MH  - Animals
MH  - *Eponyms
MH  - Female
MH  - Germany
MH  - History, 20th Century
MH  - Holocaust/*history/legislation & jurisprudence
MH  - Human Experimentation/*history/legislation & jurisprudence
MH  - Humans
MH  - National Socialism/*history
MH  - War Crimes/history/legislation & jurisprudence
MH  - *World War II
PS  - Clauberg C
FPS - Clauberg, Carl
EDAT- 2013/02/12 06:00
MHDA- 2013/02/22 06:00
CRDT- 2013/02/12 06:00
PHST- 2013/02/12 06:00 [entrez]
PHST- 2013/02/12 06:00 [pubmed]
PHST- 2013/02/22 06:00 [medline]
PST - ppublish
SO  - Isr Med Assoc J. 2012 Dec;14(12):719-23.


PMID- 23390827
OWN - NLM
STAT- MEDLINE
DCOM- 20130305
LR  - 20220408
IS  - 0350-6134 (Print)
IS  - 0350-6134 (Linking)
VI  - 36
IP  - 4
DP  - 2012 Dec
TI  - Clinical and radiological morphometry of posterior parts of thoracic and lumbal
      vertebras.
PG  - 1313-7
AB  - The aim of this work is to measure clinically important dimensions of thoracic
      and lumbal vertebras. Charts of one-hundred and seventeen patients with implanted
      internal fixateur on the thoracic and lumbal spine between 01.01. 2008. and
      31.3.2010. at the Department for Orthopedics and Traumatology, of the Sarajevo
      Clinical center were retrieved, and only 14 patients, with 46 vetrtebras and 89
      pedicles have had complete documentation (clearly visible measured structures on 
      X-ray and CT scans). Digitalized antero-posterior and latero-lateral X-ray, and
      transversal and sagital CT scans were basic inputs for measurement of height and 
      width of the pedicle--PH, PW, axial and vertical cortico-cortical transpedicular 
      distances--AL, VL, and interpedicular distance--IP. The correction of enlargement
      on X-ray pictures was performed according to known dimensions of implants and
      length scale on CT scans. Enlargement of those parameters, from T1 to L5 level
      was from 50 to 150%. This increasing was not always linear, sometimes there was
      even decreasing. For instance, the IP on second and third thoracic vertebra was
      shorter compared to the first thoracic vertebra. Pedicles from the third to the
      eighth thoracic vertebra were narrower compared to the second thoracic vertebra. 
      The importance of this work is in to analyze the mentioned dimensions by methods 
      available to the clinician. Every other in vivo measurement is impossible because
      of the excessive surgical approach, while preoperative CT scanning with a great
      number of slices per one millimeter for this purpose is not ethical.
FAU - Biscevic, Mirza
AU  - Biscevic M
AD  - University of Sarajevo, Sarajevo Clinical Center, Department of Orthopedics and
      Traumatology, Sarajevo, Bosnia and Herzegovina.
FAU - Biscevic, Sejla
AU  - Biscevic S
FAU - Ljuca, Farid
AU  - Ljuca F
FAU - Smrke, Barbara U R
AU  - Smrke BU
FAU - Kapur, Eldan
AU  - Kapur E
FAU - Tezer, Mehmet
AU  - Tezer M
FAU - Smrke, Dragica
AU  - Smrke D
LA  - eng
PT  - Journal Article
PL  - Croatia
TA  - Coll Antropol
JT  - Collegium antropologicum
JID - 8003354
SB  - IM
MH  - Humans
MH  - *Internal Fixators
MH  - Lumbar Vertebrae/*diagnostic imaging/*surgery
MH  - Spinal Diseases/diagnostic imaging/surgery
MH  - *Spinal Fusion
MH  - Thoracic Vertebrae/*diagnostic imaging/*surgery
MH  - Tomography, X-Ray Computed
EDAT- 2013/02/09 06:00
MHDA- 2013/03/06 06:00
CRDT- 2013/02/09 06:00
PHST- 2013/02/09 06:00 [entrez]
PHST- 2013/02/09 06:00 [pubmed]
PHST- 2013/03/06 06:00 [medline]
PST - ppublish
SO  - Coll Antropol. 2012 Dec;36(4):1313-7.


PMID- 23390812
OWN - NLM
STAT- MEDLINE
DCOM- 20130305
LR  - 20130208
IS  - 0350-6134 (Print)
IS  - 0350-6134 (Linking)
VI  - 36
IP  - 4
DP  - 2012 Dec
TI  - Diagnoses of suicidum and tentamen suicidi in the registers of patients of the
      Kingdom of Yugoslavia's Banovina Public General Hospital in Bjelovar from
      1931-1940.
PG  - 1205-9
AB  - Suicide has been a subject of research of philosophy, ethics, religion and
      medicine for centuries. Attitudes towards it changed during the history, from
      condemnation of suicide as an unethical act to the theory of suicide as the
      utmost expression of a human as an individual. Croatia, with the annual suicide
      rate above 20 percent belongs to the high-risk countries. Suicide frequency
      varies from region to region, while the suicide rates for the County
      Bjelovarsko-bilogorska have been well above Croatia's average for decades. The
      aim of this retrospective study was to establish some epidemiological features of
      hospital patients with the diagnoses of "suicidum" and "tentamen suicidi" on the 
      basis of records available in the registers of patients of General Hospital in
      Bjelovar in the period between 1931 and 1940. In the observed period,
      thirty-three people were treated in hospital for suicide attempt, seven of them
      dying. An equal number of men and women attempted suicide (13:13), while in the
      group of those who died, the ratio was more in favour of women (4:3). Suicide
      incidence was highest in November, followed by May and June, with the most common
      method for suicide being acetic acid.
FAU - Sklebar, Duska
AU  - Sklebar D
AD  - Bjelovar General Hospital, Department of Neurology, Bjelovar, Croatia.
      dsklebar@gmail.com
FAU - Vrabec-Matkovic, Dragica
AU  - Vrabec-Matkovic D
FAU - Catipovic, Marija
AU  - Catipovic M
FAU - Sklebar, Ivan
AU  - Sklebar I
LA  - eng
PT  - Journal Article
PL  - Croatia
TA  - Coll Antropol
JT  - Collegium antropologicum
JID - 8003354
SB  - IM
MH  - Adult
MH  - Croatia/epidemiology
MH  - Female
MH  - Hospitals, General/*statistics & numerical data
MH  - Hospitals, Public/statistics & numerical data
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Registries/statistics & numerical data
MH  - Retrospective Studies
MH  - Suicide/*ethnology/*statistics & numerical data
MH  - Suicide, Attempted/*ethnology/*statistics & numerical data
MH  - Young Adult
MH  - Yugoslavia/epidemiology
EDAT- 2013/02/09 06:00
MHDA- 2013/03/06 06:00
CRDT- 2013/02/09 06:00
PHST- 2013/02/09 06:00 [entrez]
PHST- 2013/02/09 06:00 [pubmed]
PHST- 2013/03/06 06:00 [medline]
PST - ppublish
SO  - Coll Antropol. 2012 Dec;36(4):1205-9.


PMID- 23390802
OWN - NLM
STAT- MEDLINE
DCOM- 20130305
LR  - 20130208
IS  - 0350-6134 (Print)
IS  - 0350-6134 (Linking)
VI  - 36
IP  - 4
DP  - 2012 Dec
TI  - The factor of local cultural specificity and process of globalization.
PG  - 1135-8
AB  - Cultural polymorphism is a difficult phenomenon, which has multiform influence on
      the society's life. The active interest of society to local folk knowledge in
      life-support activities and Nature using is one of the distinctive marks of
      modern time. This interest has fallen on the period of active transformations of 
      environment as a result of industrial society's pressing on Nature, and the
      generating of new approaches in the studying of Nature and human activity based
      on the "technologies" of wild life. The success of humankind in creating
      artificial surroundings has led to both great success in improving the quality of
      peoples' lives, and also to problems with renewable resources and human health
      and to changing for the worse ecology. In 1992 the Unites Nations Conference on
      Environment and Development (Rio de Janeiro, Brazil) set fixed standards defining
      global violations of the environment. The zAgenda 21', adopted at this
      Conference, focused on the necessity of new solutions for problems of the
      relationships between Nature and Society, mentioning interdisciplinary research
      as a positive way to search for solutions to new problems, and citing as a goal a
      zbalance of Nature, Society and Humans'. Pre-industrial society had a different
      experience in using Nature and solving problems of life-support activity under a 
      regime of sparing nature. Experience has shown that Folk knowledge and Folk
      technology can, in a number of instances, actually assist in solving high level
      problems caused by human impact on the environment, e.g., farming methods, and,
      as a result offering possibilities for a more sound and at the same time
      effective basis for long-term sustainable production at the local level. The
      traditional cultures of Eurasia were engaged in agricultural pursuits and had
      acquired unique experiences in maintaining soil fertility and a technology which 
      limited the impact they were having on the environment. The value of Folk
      heritage in exploiting the environment, especially farming traditions in
      small-scale, non-industrial societies, has been based not only on the
      technologies that are "friendly" to Nature, but also (and first of all) on the
      perception that soil (earth) is the source of all life. This sort of perception
      was particularly widespread among peoples of pre-industrial societies. The
      problem of searching for a way to increase long-term productivity in food grain
      production is complicated. This problem is of global importance for today and the
      future. The active interest of Modern society in the Folk experiences of using
      the Nature to achieve sustainable economies is yet to come, but we have much to
      learn from these small-scale non-industrial societies. Food production needs to
      be increased. At the same time, the fertility of the soil must be maintained.
      Achieving a balance between these two necessities is the problem. Changing the
      present modern human outlook from its egocentric position to one that understands
      and respects the natural environment, based on ideas of "ecological ethics",
      looks especially complex, and is directly connected with the problem of forming a
      new culture. Actually, the global ecological crisis and related ecological
      problems take priority and the transition to a new model of thinking promises to 
      be accelerated. In this context, making use of Folk heritage, Folk knowledge and 
      experience in observing Nature and using Nature to achieve harmonious
      interrelations in a "Nature - Society" system, and for the elaboration of a
      change of attitudes is quite important for modern society on a Global level to
      achieve ways of Sustainability. Lucius Seneca maintains that subjugation of a
      Nature is possible only if obeying to Nature. Modern epoch of Globalization in
      economy and Financial systems creating a potential of high risks for mankind on
      the Global level. Special attention to local factors (local experience in Nature 
      using, local Folk experience in Life-support activity) in context of
      globalization problems is important today. Actually, Glocalization can assist in 
      adaptation process of harmonizing local and global needs to a way of
      Sustainability. Glocalization puts globalization problems down to the human
      scale. The age of Globalization has made the problem of cultural dialog extra
      actual, otherwise the Mankind has no chance to survive. The Glocalization is the 
      process of creation of a harmony in Nature, Society and Humans system in the
      context of Sustainability.
FAU - Rudnev, Viacheslav
AU  - Rudnev V
AD  - Institute of Ethnology and Anthropology, Russian Academy of Sciences, Moscow,
      Russia. roudnev@mail.ru
LA  - eng
PT  - Journal Article
PL  - Croatia
TA  - Coll Antropol
JT  - Collegium antropologicum
JID - 8003354
SB  - IM
MH  - Conservation of Natural Resources/*trends
MH  - Cross-Cultural Comparison
MH  - Culture
MH  - Ecology/*trends
MH  - *Folklore
MH  - Humans
MH  - *Internationality
MH  - Russia
EDAT- 2013/02/09 06:00
MHDA- 2013/03/06 06:00
CRDT- 2013/02/09 06:00
PHST- 2013/02/09 06:00 [entrez]
PHST- 2013/02/09 06:00 [pubmed]
PHST- 2013/03/06 06:00 [medline]
PST - ppublish
SO  - Coll Antropol. 2012 Dec;36(4):1135-8.


PMID- 23390789
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20130208
IS  - 0125-2208 (Print)
IS  - 0125-2208 (Linking)
VI  - 95
IP  - 12
DP  - 2012 Dec
TI  - Prevalence of vitamin D deficiency in nurses at the Royal Irrigation Hospital.
PG  - 1569-74
AB  - BACKGROUND: Vitamin D deficiency can cause organ dysfunction in the body,
      especially the bones and affect calcium metabolism. It is the main cause of
      osteoporosis and may increase the risk of hip fracture later in life.
      Furthermore, new studies show that vitamin D deficiency can increase the risk of 
      many chronic illnesses, including common cancers, as well as autoimmune,
      infectious, and cardiovascular disease. OBJECTIVE: To determine the prevalence of
      vitamin D (25(OH)D) deficiency and the factors influencing vitamin D status in
      relation to serum 25-hydroxy vitamin D, for example: daily sun-protective
      clothing, food and milk intake, sun exposure, sunscreen usage and bone mineral
      density (BMD). MATERIAL AND METHOD: The present study was approved by the ethics 
      committee of the Royal Irrigation Hospital. Blood samples were collected from 217
      nurses working at the Royal Irrigation Hospital. Serum 25(OH)D and bone density
      were measured by HPLC and DEXA, respectively. Drugs intake, lifestyle, and
      dietary habits were assessed via a questionnaire. Demographic data were analyzed 
      using descriptive statistics and the correlations between factors and vitamin D
      level were analyzed using Chi-square. RESULTS: The prevalence of hypovitaminosis 
      D was 95.4%. Sunscreen usage was associated with deficiency (p < 0.05).
      CONCLUSION: The authors found a high prevalence of hypovitaminosis D in nurses at
      the Royal Irrigation Hospital.
FAU - Hattapornsawan, Yongyot
AU  - Hattapornsawan Y
AD  - Department of Health, Ministry of Public Health, Bangkok, Thailand.
      yongyot77@hotmail.com
FAU - Pangsuwan, Supunnee
AU  - Pangsuwan S
FAU - Ongphiphadhanakul, Boonsong
AU  - Ongphiphadhanakul B
FAU - Udomsubpayakun, Umaporn
AU  - Udomsubpayakun U
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Thailand
TA  - J Med Assoc Thai
JT  - Journal of the Medical Association of Thailand = Chotmaihet thangphaet
JID - 7507216
SB  - IM
MH  - Adult
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nursing Staff, Hospital/*statistics & numerical data
MH  - Prevalence
MH  - Thailand/epidemiology
MH  - Vitamin D Deficiency/*diagnosis/*epidemiology
MH  - Young Adult
EDAT- 2013/02/09 06:00
MHDA- 2013/03/13 06:00
CRDT- 2013/02/09 06:00
PHST- 2013/02/09 06:00 [entrez]
PHST- 2013/02/09 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
PST - ppublish
SO  - J Med Assoc Thai. 2012 Dec;95(12):1569-74.


PMID- 23390336
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130208
LR  - 20211021
IS  - 0253-0716 (Print)
IS  - 0253-0716 (Linking)
VI  - 37
IP  - 4
DP  - 2012 Dec
TI  - Scientific publications on medical ethics in thomson reuters database, 1990-2010.
PG  - 277-8
FAU - Morovati, Marzieh
AU  - Morovati M
AD  - Department of Library and Information Sciences, Shiraz University of Medical
      Sciences, Shiraz, Iran;
FAU - Ejraei, Akbar
AU  - Ejraei A
FAU - Hadi, Zohre
AU  - Hadi Z
FAU - Atefi, Mohammad
AU  - Atefi M
FAU - Morovati, Mohammad Javad
AU  - Morovati MJ
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Med Sci
JT  - Iranian journal of medical sciences
JID - 8104374
PMC - PMC3565203
EDAT- 2013/02/08 06:00
MHDA- 2013/02/08 06:01
CRDT- 2013/02/08 06:00
PHST- 2012/02/26 00:00 [received]
PHST- 2012/06/11 00:00 [revised]
PHST- 2012/06/25 00:00 [accepted]
PHST- 2013/02/08 06:00 [entrez]
PHST- 2013/02/08 06:00 [pubmed]
PHST- 2013/02/08 06:01 [medline]
PST - ppublish
SO  - Iran J Med Sci. 2012 Dec;37(4):277-8.


PMID- 23389366
OWN - NLM
STAT- MEDLINE
DCOM- 20130329
LR  - 20191210
IS  - 2038-2529 (Electronic)
IS  - 0300-8916 (Linking)
VI  - 98
IP  - 6
DP  - 2012 Nov
TI  - Percutaneous computed tomography-guided lung biopsies: preliminary results using 
      an augmented reality navigation system.
PG  - 775-82
LID - 10.1700/1217.13503 [doi]
AB  - AIMS AND BACKGROUND: "Augmented reality" is a technique to create a composite
      view by augmenting the real intervention field, visualized by the doctor, with
      additional information coming from a virtual volume generated using computed
      tomography (CT), magnetic resonance or ultrasound images previously acquired from
      the same patient. In the present study we verified the accuracy and validated the
      clinical use of an augmented reality navigation system produced to perform
      percutaneous CT-guided lung biopsies. METHODS: One hundred and eighty consecutive
      patients with solitary parenchymal lung lesions, enrolled using a nonrandom
      enrollment system, underwent percutaneous CT-guided aspiration and core biopsy
      using a traditional technique (group C, 90 patients) and navigation system
      assistance (group S, 90 patients). For each patient we recorded the largest
      lesion diameter, procedure time, overall number of CT scans, radiation dose, and 
      complications. The entire experimental project was evaluated and approved by the 
      local institutional review board (ethics committee). RESULTS: Each procedure was 
      concluded successfully and a pathological diagnosis was reached in 96% of cases
      in group S and 90% of cases in group C. Procedure time, overall number of CT
      scans and incident x-ray radiation dose (CTDIvol) were significantly reduced in
      navigation system-assisted procedures (P <0.001; z = 5.64) compared with
      traditional CT-guided procedures. The percentage of procedural complications was 
      14% in group S and 17% in group C. CONCLUSION: The augmented reality navigation
      system used in this study was a highly safe, technically reliable and effective
      support tool in percutaneous CT-guided lung biopsy, allowing to shorten the
      procedure time and reduce the incident x-ray radiation dose to patients and the
      rate of insufficient specimens. Furthermore, it has the potential to increase the
      number of procedures executed in the allocated time without increasing the number
      of complications.
FAU - Grasso, Rosario Francesco
AU  - Grasso RF
AD  - Universita Campus Bio-Medico, Via Alvaro Del Portillo 200, Rome, Italy.
FAU - Luppi, Giacomo
AU  - Luppi G
FAU - Cazzato, Roberto Luigi
AU  - Cazzato RL
FAU - Faiella, Eliodoro
AU  - Faiella E
FAU - D'Agostino, Francesco
AU  - D'Agostino F
FAU - Beomonte Zobel, Daniela
AU  - Beomonte Zobel D
FAU - De Lena, Mario
AU  - De Lena M
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Validation Study
PL  - United States
TA  - Tumori
JT  - Tumori
JID - 0111356
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biopsy, Needle/instrumentation/*methods
MH  - Female
MH  - Humans
MH  - Italy
MH  - Lung/diagnostic imaging/*pathology/surgery
MH  - Lung Neoplasms/*diagnosis/diagnostic imaging/pathology/surgery
MH  - Male
MH  - Middle Aged
MH  - Operative Time
MH  - Prospective Studies
MH  - Radiation Dosage
MH  - Surgery, Computer-Assisted/instrumentation/*methods
MH  - *Tomography, X-Ray Computed/instrumentation
MH  - *User-Computer Interface
EDAT- 2013/02/08 06:00
MHDA- 2013/03/30 06:00
CRDT- 2013/02/08 06:00
PHST- 2013/02/08 06:00 [entrez]
PHST- 2013/02/08 06:00 [pubmed]
PHST- 2013/03/30 06:00 [medline]
AID - 10.1700/1217.13503 [doi]
PST - ppublish
SO  - Tumori. 2012 Nov;98(6):775-82. doi: 10.1700/1217.13503.


PMID- 23387093
OWN - NLM
STAT- MEDLINE
DCOM- 20130424
LR  - 20181202
IS  - 1107-0625 (Print)
IS  - 1107-0625 (Linking)
VI  - 17
IP  - 4
DP  - 2012 Oct-Dec
TI  - Science ethics education course.
PG  - 804; author's reply p. 804
FAU - Joob, Beuy
AU  - Joob B
FAU - Wiwanitkit, Viroj
AU  - Wiwanitkit V
LA  - eng
PT  - Letter
PT  - Comment
PL  - Cyprus
TA  - J BUON
JT  - Journal of B.U.ON. : official journal of the Balkan Union of Oncology
JID - 100883428
SB  - IM
CON - J BUON. 2011 Oct-Dec;16(4):771-7. PMID: 22331736
CON - J BUON. 2012 Apr-Jun;17(2):391-5. PMID: 22740224
MH  - *Attitude
MH  - Biomedical Research/*ethics
MH  - *Ethics, Research
MH  - Female
MH  - Humans
MH  - Male
MH  - Publishing/*ethics
MH  - *Research Personnel
MH  - Scientific Misconduct/*ethics/*psychology
EDAT- 2013/02/08 06:00
MHDA- 2013/04/25 06:00
CRDT- 2013/02/08 06:00
PHST- 2013/02/08 06:00 [entrez]
PHST- 2013/02/08 06:00 [pubmed]
PHST- 2013/04/25 06:00 [medline]
PST - ppublish
SO  - J BUON. 2012 Oct-Dec;17(4):804; author's reply p. 804.


PMID- 23386097
OWN - NLM
STAT- MEDLINE
DCOM- 20131213
LR  - 20211203
IS  - 2317-6385 (Electronic)
IS  - 1679-4508 (Linking)
VI  - 10
IP  - 4
DP  - 2012 Oct-Dec
TI  - Relationship between sleep deprivation and anxiety--experimental research
      perspective.
PG  - 519-23
LID - S1679-45082012000400022 [pii]
AB  - Sleep deprivation is a condition that is more and more observed in modern society
      bringing various neurobehavioral effects, being anxious states one of the main
      problems. Many studies have successfully demonstrated the relationship between
      sleep deprivation and anxiety in clinical research. As to basic experimentation, 
      various models have been efficiently used in order to evaluate an anxious
      behavior. However, the same efficacy is not found on basic studies that deal with
      the relationship between paradoxical sleep and anxiety. The great majority of
      studies which approach this matter in animal models do not present results that
      may be applied to clinical practice and this is basically due to two reasons:
      inconsistency among results and lack of replicability as related to clinical
      studies. It has to be emphasized that the use of animal models is extremely
      useful, mainly under experimental conditions which cannot be ethically or
      plausibly be approached in human beings. So, the present theoretical assay tries 
      to evaluate in a brief and critical manner the applicability of animal models in 
      sleep deprivation under a translational perspective.
FAU - Pires, Gabriel Natan
AU  - Pires GN
AD  - Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil.
FAU - Tufik, Sergio
AU  - Tufik S
FAU - Andersen, Monica Levy
AU  - Andersen ML
LA  - eng
LA  - por
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Brazil
TA  - Einstein (Sao Paulo)
JT  - Einstein (Sao Paulo, Brazil)
JID - 101281800
SB  - IM
MH  - Animals
MH  - Anxiety/*physiopathology
MH  - Humans
MH  - *Models, Animal
MH  - Sleep/*physiology
MH  - Sleep Deprivation/*physiopathology/psychology
MH  - Sleep, REM/physiology
MH  - Translational Research, Biomedical
EDAT- 2013/02/07 06:00
MHDA- 2013/12/18 06:00
CRDT- 2013/02/07 06:00
PHST- 2012/04/16 00:00 [received]
PHST- 2012/08/17 00:00 [accepted]
PHST- 2013/02/07 06:00 [entrez]
PHST- 2013/02/07 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
AID - S1679-45082012000400022 [pii]
AID - 10.1590/s1679-45082012000400022 [doi]
PST - ppublish
SO  - Einstein (Sao Paulo). 2012 Oct-Dec;10(4):519-23. doi:
      10.1590/s1679-45082012000400022.


PMID- 23386026
OWN - NLM
STAT- MEDLINE
DCOM- 20131202
LR  - 20191112
IS  - 2317-6385 (Electronic)
IS  - 1679-4508 (Linking)
VI  - 10
IP  - 3
DP  - 2012 Jul-Sep
TI  - Experimental adaptation of an influenza H5HA strain confers respiratory droplet
      transmission to reassortant H5H/H1N1 virus strain in ferrets.
PG  - 391-3
LID - S1679-45082012000300026 [pii]
AB  - An evaluation of the role - if any - of censorship in scientific papers, based on
      the publishing of the article that shows it is possible to modify the genetics of
      the H5N1 aviary influenza virus, enhancing its transmission among mammals, which 
      was followed by much ado and ethical discussion.
FAU - Pasternak, Jacyr
AU  - Pasternak J
AD  - Hospital Israelita Albert Einstein, Sao Paulo, SP, Brasil.
LA  - eng
LA  - por
PT  - Journal Article
PL  - Brazil
TA  - Einstein (Sao Paulo)
JT  - Einstein (Sao Paulo, Brazil)
JID - 101281800
SB  - IM
MH  - Access to Information/*ethics
MH  - Animals
MH  - Biomedical Research/*ethics
MH  - Bioterrorism/prevention & control
MH  - *Diffusion of Innovation
MH  - Disease Models, Animal
MH  - Ferrets/virology
MH  - Influenza A Virus, H1N1 Subtype/genetics/pathogenicity
MH  - Influenza A Virus, H5N1 Subtype/genetics/pathogenicity
MH  - Orthomyxoviridae Infections/transmission
MH  - Periodicals as Topic/*ethics
MH  - Reassortant Viruses
EDAT- 2013/02/07 06:00
MHDA- 2013/12/16 06:00
CRDT- 2013/02/07 06:00
PHST- 2012/05/07 00:00 [received]
PHST- 2012/05/09 00:00 [accepted]
PHST- 2013/02/07 06:00 [entrez]
PHST- 2013/02/07 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - S1679-45082012000300026 [pii]
AID - 10.1590/s1679-45082012000300026 [doi]
PST - ppublish
SO  - Einstein (Sao Paulo). 2012 Jul-Sep;10(3):391-3. doi:
      10.1590/s1679-45082012000300026.


PMID- 23386014
OWN - NLM
STAT- MEDLINE
DCOM- 20131202
LR  - 20191112
IS  - 2317-6385 (Electronic)
IS  - 1679-4508 (Linking)
VI  - 10
IP  - 3
DP  - 2012 Jul-Sep
TI  - Quality of health and medication information on Brazilian websites.
PG  - 335-41
LID - S1679-45082012000300014 [pii]
AB  - OBJECTIVE: To evaluate the quality of information about health and medication
      available on Brazilian websites. METHODS: A descriptive study with a quantitative
      approach regarding Brazilian websites, conducted from January to March 2011. The 
      search sites were located using two search phrases: "medication information" and 
      "health information." The choice of variables was based on the Internet
      information quality criteria of the World Health Organization and the
      International Code of Ethics for health and services sites on the Internet. The
      dependent variable was whether the site had information about health or
      medication. The independent variables were access, appearance, organization,
      honesty, transparency, responsibility and origin. For statistical analysis, the
      chi(2) and Fisher exact tests were applied, with a significance level of 5%.
      RESULTS: Of the 37 Brazilian sites analyzed, 24 (64.9%) contained health
      information and 13 (35.1%) contained medication information. Regarding
      appearance, organization and access criteria, most sites related to health and
      medication were easily accessible, easy to understand, used objective language,
      were updated and organized logically and provided accurate and scientifically
      grounded information. CONCLUSION: The honesty criterion differed significantly
      between sites, and the quality of information presented on health and medication 
      websites showed significant differences, suggesting the need for a more
      systematic organization of these topics on the Internet.
FAU - Gondim, Ana Paula Soares
AU  - Gondim AP
AD  - Universidade de Fortaleza, Fortaleza, CE, Brasil.
FAU - Weyne, Davi Pontes
AU  - Weyne DP
FAU - Ferreira, Bruno Sousa Pinto
AU  - Ferreira BS
LA  - eng
LA  - por
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Brazil
TA  - Einstein (Sao Paulo)
JT  - Einstein (Sao Paulo, Brazil)
JID - 101281800
SB  - IM
MH  - Brazil
MH  - Consumer Health Information/*standards
MH  - Drug Information Services/standards
MH  - Humans
MH  - Information Services/*standards
MH  - Internet/*standards
MH  - Quality Control
EDAT- 2013/02/07 06:00
MHDA- 2013/12/16 06:00
CRDT- 2013/02/07 06:00
PHST- 2011/11/27 00:00 [received]
PHST- 2012/02/28 00:00 [accepted]
PHST- 2013/02/07 06:00 [entrez]
PHST- 2013/02/07 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - S1679-45082012000300014 [pii]
AID - 10.1590/s1679-45082012000300014 [doi]
PST - ppublish
SO  - Einstein (Sao Paulo). 2012 Jul-Sep;10(3):335-41. doi:
      10.1590/s1679-45082012000300014.


PMID- 23386007
OWN - NLM
STAT- MEDLINE
DCOM- 20131202
LR  - 20191112
IS  - 2317-6385 (Electronic)
IS  - 1679-4508 (Linking)
VI  - 10
IP  - 3
DP  - 2012 Jul-Sep
TI  - Isolation and characterization of mesenchymal stem cells obtained from reusable
      and disposable bone marrow collection filters.
PG  - 296-301
LID - S1679-45082012000300007 [pii]
AB  - OBJECTIVE: To compare human mesenchymal stem cells obtained from reusable and
      disposable filters and to characterize them according to the criteria of the
      International Society of Cellular Therapy. METHODS: Human mesenchymal stem cells 
      were isolated from bone marrow collection reusable sets and compared with those
      obtained from disposable sets by washing the filters with cell culture media. The
      isolated cells were characterized according to the criteria of the International 
      Society of Cellular Therapy using flow cytometry, differentiation in vitro, and
      cytochemistry techniques. RESULTS: Samples were obtained from disposable (n=3)
      and from reusable collection sets (n=3). All samples obtained from bone marrow
      disposable sets successfully produced mesenchymal stem cells. All bone marrow
      derived mesenchymal stem cells were characterized and fulfilled the criteria
      established by International Society of Cellular Therapy. CONCLUSION: This study 
      showed that mesenchymal stem cells can also be obtained from reusable collection 
      sets (which are still used in several centers around the world) to be employed in
      research as an alternative and ethical source.
FAU - Deus, Glaziane Cordeiro de
AU  - Deus GC
AD  - Hospital Israelita Albert Einstein, Sao Paulo, SP, Brasil.
FAU - Normanton, Marilia
AU  - Normanton M
FAU - Hamerschlak, Nelson
AU  - Hamerschlak N
FAU - Kondo, Andrea Tiemi
AU  - Kondo AT
FAU - Ribeiro, Andreza Alice Feitosa
AU  - Ribeiro AA
FAU - Goldberg, Anna Carla
AU  - Goldberg AC
FAU - Marti, Luciana Cavalheiro
AU  - Marti LC
LA  - eng
LA  - por
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Brazil
TA  - Einstein (Sao Paulo)
JT  - Einstein (Sao Paulo, Brazil)
JID - 101281800
SB  - IM
MH  - *Bone Marrow
MH  - Bone Marrow Cells/*cytology
MH  - Cell Separation/ethics/*methods
MH  - Cells, Cultured
MH  - Disposable Equipment
MH  - Filtration/instrumentation
MH  - Humans
MH  - Immunohistochemistry
MH  - Mesenchymal Stem Cells/*cytology
EDAT- 2013/02/07 06:00
MHDA- 2013/12/16 06:00
CRDT- 2013/02/07 06:00
PHST- 2012/03/06 00:00 [received]
PHST- 2012/05/06 00:00 [accepted]
PHST- 2013/02/07 06:00 [entrez]
PHST- 2013/02/07 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - S1679-45082012000300007 [pii]
AID - 10.1590/s1679-45082012000300007 [doi]
PST - ppublish
SO  - Einstein (Sao Paulo). 2012 Jul-Sep;10(3):296-301. doi:
      10.1590/s1679-45082012000300007.


PMID- 23383582
OWN - NLM
STAT- MEDLINE
DCOM- 20130305
LR  - 20191112
IS  - 1521-0987 (Print)
IS  - 1938-9019 (Linking)
VI  - 13
IP  - 4
DP  - 2012
TI  - Care management role in end-of-life discussions.
PG  - 180-3
AB  - How do we prepare our patients for decisions that will need to be made for
      end-of-life care? End-of-life care discussions should occur early on in the
      patient's disease process and often requires a great deal of coordination between
      multiple caregivers. There are also ethical, cultural social and spiritual
      considerations during this very important time in the disease process. Research
      suggests that we are not doing an adequate job of addressing end-of-life care
      with our patients and that a great deal of money and resources are being spent in
      the last days of life when there may be no clinical indication to do so.
      Registered nurse case managers have a unique knowledge base to serve in the role 
      of coordinating care and leading the multidisciplinary care team in an effort to 
      use resources responsibly while providing patients and families with options for 
      end-of-life care.
FAU - Meyer, Star
AU  - Meyer S
AD  - Care Management and Hospitalist Department, West Lafayette, IN 47906, USA.
      star.may@myemail.indwes.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Care Manag J
JT  - Care management journals : Journal of case management ; The journal of long term 
      home health care
JID - 100888264
SB  - IM
MH  - Advance Care Planning/organization & administration/standards
MH  - Caregivers/*organization & administration
MH  - Communication
MH  - Decision Making
MH  - Humans
MH  - Patient Care Management/methods/*organization & administration/standards
MH  - Patient Care Team/organization & administration/standards
MH  - Professional-Patient Relations
MH  - Terminal Care/methods/*organization & administration/standards
EDAT- 2013/02/07 06:00
MHDA- 2013/03/06 06:00
CRDT- 2013/02/07 06:00
PHST- 2013/02/07 06:00 [entrez]
PHST- 2013/02/07 06:00 [pubmed]
PHST- 2013/03/06 06:00 [medline]
AID - 10.1891/1521-0987.13.4.180 [doi]
PST - ppublish
SO  - Care Manag J. 2012;13(4):180-3. doi: 10.1891/1521-0987.13.4.180.


PMID- 23383565
OWN - NLM
STAT- MEDLINE
DCOM- 20130307
LR  - 20170303
IS  - 0017-0011 (Print)
IS  - 0017-0011 (Linking)
VI  - 83
IP  - 10
DP  - 2012 Oct
TI  - [Treatment of arterial hypertension in pregnancy in relation to current
      guidelines of the Polish Society of Arterial Hypertension from 2011].
PG  - 778-83
AB  - Arterial hypertension concerns 7-10% of pregnancies and leads to an increased
      risk of complications for both, the mother and the child. This rate will probably
      rise in the years to come due to the notable tendency among women to delay the
      decision to become pregnant - values of blood pressure and occurrence of arterial
      hypertension increase with age, as well as due to the growing problem of obesity 
      resulting from inappropriate dietary habits and lack of regular everyday physical
      activity. Difficulties with management of that clinical condition are partly
      related with lack of unified and widely accepted guidelines. Different opinions
      in the subject of terminology and classification of pregnancy hypertension or
      indications for pharmacotherapy as well as choice of the optimal antihypertensive
      drug, emerge from objective causes such as combination of various pathogenetic
      factors typical for arterial hypertension itself and those connected with
      pregnancy elsewhere stressed priorities of therapy from the point of view of the 
      health of the mother and of the fetus, as well as lack of randomized clinical
      trials due to obvious ethical purposes, but also from the fact that pregnancy
      hypertension is a focus of attention for different specialists - obstetricians,
      hypertensiologists and perinatologists. A good cooperation regarding experience
      and information among all of these specializations would be the most beneficial
      for pregnant women and their children. Lack of new modern antihypertensive
      agents, safe and effective in pregnancy while the older ones are being withdrawn 
      from the market as their production is no longer cost-effective for
      pharmacological companies, has become an increasing problem in many countries,
      and Poland among them. The aim of the following publication was to present the
      statement on management of pregnancy hypertension from the current guidelines of 
      the Polish Society of Arterial Hypertension 2011 to gynecologists and
      obstetricians, with a commentary According to the guidelines, methyldopa,
      labetalol (or metoprolol), long-acting nifedipine or verapamil should be used in 
      the therapy of mild and moderate pregnancy hypertension, preferably in the given 
      order In case of severe and life-threatening arterial hypertension, labetalol
      intravenously should be administered and if it is still not sufficient,
      eventually sodium nitroprusside or hydralazine could be ordered, bearing in mind 
      their possible adverse effects. Unfortunately labetalol, nifedipine, hydralazine 
      and sodium nitroprusside are no longer available in Poland, which significantly
      narrows the practical treatment possibilities in the pregnant population.
      Inhibitors of angiotensin converting enzyme and angiotensin II receptor blockers 
      are contraindicated during pregnancy and breastfeeding, as well as aldosteron
      inhibitors, as suggest in the guidelines. In the paper the authors present the
      guidelines and also, based on the information available to date in medical
      journals, other hypertension pharmacotherapeutic options possible for
      consideration in pregnancy which could be helpful in management of severe
      arterial hypertension in pregnancy.
FAU - Szczepaniak-Chichel, Ludwina
AU  - Szczepaniak-Chichel L
AD  - Katedra i Klinika Hipertensjologii, Angiologii i Chorob Wewnetrznych,
      Uniwersytetu Medycznego im. Karola Marcinkowskiego w Poznaniu, Polska.
      szczepaniak-chichel@o2.pl
FAU - Tykarski, Andrzej
AU  - Tykarski A
LA  - pol
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Leczenie nadcisnienia tetniczego w ciazy w swietle aktualnych wytycznych
      Polskiego Towarzystwa Nadcisnienia Tetniczego z 2011 roku.
PL  - Poland
TA  - Ginekol Pol
JT  - Ginekologia polska
JID - 0374641
RN  - 0 (Antihypertensive Agents)
SB  - IM
MH  - Antihypertensive Agents/therapeutic use
MH  - Disease Management
MH  - Female
MH  - HELLP Syndrome/diagnosis/therapy
MH  - Humans
MH  - Hypertension, Pregnancy-Induced/classification/*diagnosis/*therapy
MH  - Poland
MH  - Practice Guidelines as Topic
MH  - Pre-Eclampsia/diagnosis/therapy
MH  - Pregnancy
MH  - Prenatal Care/*methods
MH  - Prenatal Diagnosis/*standards
MH  - Societies, Medical
MH  - *Women's Health
EDAT- 2013/02/07 06:00
MHDA- 2013/03/08 06:00
CRDT- 2013/02/07 06:00
PHST- 2013/02/07 06:00 [entrez]
PHST- 2013/02/07 06:00 [pubmed]
PHST- 2013/03/08 06:00 [medline]
PST - ppublish
SO  - Ginekol Pol. 2012 Oct;83(10):778-83.


PMID- 23382753
OWN - NLM
STAT- MEDLINE
DCOM- 20130918
LR  - 20220321
IS  - 1729-0503 (Electronic)
IS  - 1680-6905 (Linking)
VI  - 12
IP  - 3
DP  - 2012 Sep
TI  - Pattern of bacterial isolates in the middle ear discharge of patients with
      chronic suppurative otitis media in a tertiary hospital in North central Nigeria.
PG  - 362-7
AB  - BACKGROUND: Otitis media (OM) is a major health problem in both developed and
      developing countries. OBJECTIVE: To determine the pattern of bacterial isolates
      in patients with chronic suppurative otitis media(CSOM) in Ilorin, Nigeria.
      METHODS: A prospective study carried out in University of Ilorin Teaching
      Hospital, Nigeria among consenting patients with CSOM attending the ENT clinic
      over a period of 7months. Informed consent was obtained from the patients or
      caregivers and approval for the study obtained from ethical committee. Structured
      questionnaire was administered and microbiological analysis done, data obtained
      was entered into SPSS statistical software and results presented in tables and
      figures. RESULTS: A total of 134 patients aged 5-64yrs with chronic suppurative
      otitis media were interviewed with a mean age of 17.0 (S.D. =15.1+/-1.30). About 
      55.2% of the respondents were under 10yrs. Seventy-two (53.7%) of the respondents
      were males with M:F=1.2:1. The gram stain showed predominantly gram negative
      organisms (71.6%). Pseudomonas aeruginosa was the commonest middle ear pathogenic
      organism identified and the sensitivity pattern highly favoured ciprofloxacin
      CONCLUSION: CSOM is still a childhood problem among the under tens' more
      prevalent among males and the commonest agent is Pseudomonas aeruginosa.
      Ciprofloxacin is still the most sensitive antibiotics in vitro.
FAU - Afolabi, O A
AU  - Afolabi OA
AD  - Department of Ear, Nose and Throat surgery, University of Ilorin, Ilorin,
      Nigeria. droaafolabi@yahoo.com
FAU - Salaudeen, A G
AU  - Salaudeen AG
FAU - Ologe, F E
AU  - Ologe FE
FAU - Nwabuisi, C
AU  - Nwabuisi C
FAU - Nwawolo, C C
AU  - Nwawolo CC
LA  - eng
PT  - Journal Article
PL  - Uganda
TA  - Afr Health Sci
JT  - African health sciences
JID - 101149451
RN  - 0 (Anti-Bacterial Agents)
RN  - 5E8K9I0O4U (Ciprofloxacin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Distribution
MH  - Anti-Bacterial Agents/therapeutic use
MH  - Child
MH  - Child, Preschool
MH  - Chronic Disease
MH  - Ciprofloxacin/therapeutic use
MH  - Ear, Middle/*microbiology
MH  - Female
MH  - Gram-Negative Bacteria/*isolation & purification
MH  - Gram-Positive Bacteria/*isolation & purification
MH  - Hospitals, Teaching
MH  - Humans
MH  - Klebsiella/isolation & purification
MH  - Klebsiella Infections/drug therapy/epidemiology
MH  - Male
MH  - Microbial Sensitivity Tests
MH  - Middle Aged
MH  - Nigeria/epidemiology
MH  - Otitis Media, Suppurative/drug therapy/epidemiology/*microbiology
MH  - Prevalence
MH  - Prospective Studies
MH  - Pseudomonas Infections/drug therapy/epidemiology
MH  - Pseudomonas aeruginosa/isolation & purification
MH  - Sex Distribution
MH  - Young Adult
PMC - PMC3557674
OTO - NOTNLM
OT  - Bacterial isolates
OT  - Otitis media
OT  - antibiotics
OT  - chronic
EDAT- 2013/02/06 06:00
MHDA- 2013/09/21 06:00
CRDT- 2013/02/06 06:00
PHST- 2013/02/06 06:00 [entrez]
PHST- 2013/02/06 06:00 [pubmed]
PHST- 2013/09/21 06:00 [medline]
AID - 10.4314/ahs.v12i3.18 [doi]
PST - ppublish
SO  - Afr Health Sci. 2012 Sep;12(3):362-7. doi: 10.4314/ahs.v12i3.18.


PMID- 23380775
OWN - NLM
STAT- MEDLINE
DCOM- 20130429
LR  - 20190911
IS  - 0080-6234 (Print)
IS  - 0080-6234 (Linking)
VI  - 46
IP  - 6
DP  - 2012 Dec
TI  - [The meaning of hysterectomy for a group of Chilean men partners of women who
      have undergone hysterectomy].
PG  - 1334-9
LID - S0080-62342012000600008 [pii]
AB  - The objective of this study was to understand the meaning of hysterectomy
      according to a group of Chilean men, partners of women who have undergone the
      procedure (MPWH). This qualitative study was performed with in-depth interviews. 
      A total of 15 men, partners of women who have undergone hysterectomy, were
      interviewed between May and September of 2010, under the approval of the Ethics
      Committees. Data analysis was performed using the phenomenological perspective
      proposed by Giorgi, and content analysis was performed according to Krippendorff.
      The Crestwell criteria were used to evaluate the trustworthiness of the analysis 
      and guarantee descriptive validity. Five dimensions emerged, which represented
      unique aspects of hysterectomy according to the men: symptoms, comments, the
      attributions of the uterus, concerns and changes in sexuality. It is essential to
      educate MPWH in terms of the support required by women undergoing hysterectomy.
      Therefore they should be included in the care plan designed for women undergoing 
      hysterectomy.
FAU - Gutierrez, Alejandra Araya
AU  - Gutierrez AA
AD  - Escuela de Enfermeria, Pontificia Universidad Catolica de Chile, Santiago, Chile.
      aarayagu@uc.cl
FAU - Soto, Maria-Teresa Urrutia
AU  - Soto MT
FAU - Suazo, Daniel Jara
AU  - Suazo DJ
FAU - Solovera, Sergio Silva
AU  - Solovera SS
FAU - Salas, Maria Jesus Lira
AU  - Salas MJ
FAU - Espinoza, Claudia Flores
AU  - Espinoza CF
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
TT  - El significado de la histerectomia para un grupo de hombres chilenos parejas de
      histerectomizadas.
PL  - Brazil
TA  - Rev Esc Enferm USP
JT  - Revista da Escola de Enfermagem da U S P
JID - 0242726
MH  - Adult
MH  - *Attitude to Health
MH  - Chile
MH  - Female
MH  - Humans
MH  - *Hysterectomy
MH  - Male
MH  - Middle Aged
MH  - Sexual Partners/*psychology
EDAT- 2013/02/06 06:00
MHDA- 2013/04/30 06:00
CRDT- 2013/02/06 06:00
PHST- 2012/01/17 00:00 [received]
PHST- 2012/05/03 00:00 [accepted]
PHST- 2013/02/06 06:00 [entrez]
PHST- 2013/02/06 06:00 [pubmed]
PHST- 2013/04/30 06:00 [medline]
AID - S0080-62342012000600008 [pii]
AID - 10.1590/s0080-62342012000600008 [doi]
PST - ppublish
SO  - Rev Esc Enferm USP. 2012 Dec;46(6):1334-9. doi: 10.1590/s0080-62342012000600008.


PMID- 23379860
OWN - NLM
STAT- MEDLINE
DCOM- 20130723
LR  - 20130205
IS  - 1365-2788 (Electronic)
IS  - 0964-2633 (Linking)
VI  - 57
IP  - 3
DP  - 2013 Mar
TI  - The place of surveillance technology in residential care for people with
      intellectual disabilities: is there an ideal model of application.
PG  - 201-15
LID - 10.1111/j.1365-2788.2011.01526.x [doi]
AB  - BACKGROUND: The demand for (care) services for people with intellectual
      disabilities (ID) is on the rise, because of an expanding population of people
      with ID as resources are concurrently diminishing. As a result, service providers
      are increasingly turning to technology as a potential answer to this problem.
      However, the use and application of surveillance technology (ST) in the care for 
      people with ID provokes conflicting reactions among ethicists and healthcare
      professionals, and no ethical consensus has been reached as of yet. The aim of
      this study was thus to provide an overview of how ST is viewed by (care)
      professionals and ethicists working in the field by investigating what the ideal 
      application of ST in the residential care for people with ID might entail.
      METHODS: Use was made of the concept mapping method as developed by Trochim; a
      computer-assisted procedure consisting of five subsequent steps: brainstorming,
      prioritising, clustering, processing by the computer and finally analysis.
      Various participants (ranging from ethicists, physicians to support workers) were
      invited on the basis of their intended (professional) background. Prior to this
      study, the views of care professionals on the (ideal) application of ST in the
      residential care of people with dementia have been consulted and analysed using
      concept mapping. A comparison between the two studies has been made. RESULTS:
      Results show that the generated views represent six categories, varying from it
      being beneficial to the client; reducing restraints and it being based on a clear
      vision to (the need for) staff to be equipped; user friendliness and attending to
      the client. The results are presented in the form of a graphic chart. Both
      studies have produced very similar results, but there are some differences, as
      there appears to be more fear for ST among care professionals in the care for
      people with ID and views are expressed from a more developmental perspective
      rather than a person-centred perspective with regard to people with dementia.
      CONCLUSIONS: When it comes to views on using technology both in dementia care and
      the care for people with ID, there appears to be an inherent duality, often
      rooted in the moral conflict between safety versus freedom or autonomy. What is
      more, elaboration on abstract concepts often presumed to be self-evident, whether
      ethical or not, has proven to be difficult. How ST is viewed and apprehended is
      not so much dependent of the care setting and care needs, but rather whether it
      is clear to everyone affected by ST, what one wants to achieve with ST.
CI  - (c) 2012 The Authors. Journal of Intellectual Disability Research (c) 2012
      Blackwell Publishing Ltd.
FAU - Niemeijer, A
AU  - Niemeijer A
AD  - Department of Nursing Home Medicine, VU University Medical Center, Amsterdam, The
      Netherlands. a.niemeijer@vumc.nl
FAU - Frederiks, B
AU  - Frederiks B
FAU - Depla, M
AU  - Depla M
FAU - Eefsting, J
AU  - Eefsting J
FAU - Hertogh, C
AU  - Hertogh C
LA  - eng
PT  - Journal Article
DEP - 20120312
PL  - England
TA  - J Intellect Disabil Res
JT  - Journal of intellectual disability research : JIDR
JID - 9206090
SB  - IM
MH  - Dementia/*therapy
MH  - Humans
MH  - Intellectual Disability/*therapy
MH  - Models, Organizational
MH  - Organizational Culture
MH  - Residential Facilities/*ethics/*organization & administration
MH  - Restraint, Physical/ethics
MH  - Safety Management/ethics/organization & administration
MH  - Security Measures/*ethics/*organization & administration
MH  - Videotape Recording
EDAT- 2013/02/06 06:00
MHDA- 2013/07/24 06:00
CRDT- 2013/02/06 06:00
PHST- 2013/02/06 06:00 [entrez]
PHST- 2013/02/06 06:00 [pubmed]
PHST- 2013/07/24 06:00 [medline]
AID - 10.1111/j.1365-2788.2011.01526.x [doi]
PST - ppublish
SO  - J Intellect Disabil Res. 2013 Mar;57(3):201-15. doi:
      10.1111/j.1365-2788.2011.01526.x. Epub 2012 Mar 12.


PMID- 23379316
OWN - NLM
STAT- MEDLINE
DCOM- 20140109
LR  - 20130205
IS  - 1471-5457 (Electronic)
IS  - 0730-9384 (Linking)
VI  - 31
IP  - 1-2
DP  - 2012 Spring-Fall
TI  - Research ethics and Institutional Review Boards. The influence of moral
      constraints on emotion research.
PG  - 67-79
LID - 10.2990/31_1-2_67 [doi]
AB  - Researchers in the twenty-first century face a set of challenges unknown to
      researchers a half century ago--the need to justify the moral acceptability of
      their research methods through formal review processes. However, the role that
      moral constraints play in the development and demise of scientific theories has
      largely gone unappreciated. The rise of Institutional Review Boards (IRB) in the 
      1960s compounded the impact of moral constraints on scientific research and on
      the theories that develop out of such highly monitored research. To demonstrate
      the effects of moral constraints on scientific theory and research, this paper
      offers a history and analysis of the interaction between evolving moral standards
      and twentieth century emotion theory. Recommendations regarding IRB reform are
      also reviewed. The paper concludes by arguing that, while appropriate IRB reform 
      is important, it cannot eliminate the need for careful reflection on the broader 
      forces that shape scientific practice and understanding.
FAU - Sontag, Michael
AU  - Sontag M
AD  - Department of General Studies and Philosophy, College of Mount St. Joseph, 5701
      Delhi Road, Cincinnati, OH 45233, USA. michael_sontag@mail.msj.edu
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - Politics Life Sci
JT  - Politics and the life sciences : the journal of the Association for Politics and 
      the Life Sciences
JID - 8800535
SB  - IM
MH  - Emotions
MH  - Ethics Committees, Research/*history
MH  - *Ethics, Research
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Morals
MH  - Psychological Theory
EDAT- 2013/02/06 06:00
MHDA- 2014/01/10 06:00
CRDT- 2013/02/06 06:00
PHST- 2013/02/06 06:00 [entrez]
PHST- 2013/02/06 06:00 [pubmed]
PHST- 2014/01/10 06:00 [medline]
AID - 10.2990/31_1-2_67 [doi]
PST - ppublish
SO  - Politics Life Sci. 2012 Spring-Fall;31(1-2):67-79. doi: 10.2990/31_1-2_67.


PMID- 23379314
OWN - NLM
STAT- MEDLINE
DCOM- 20140109
LR  - 20130205
IS  - 1471-5457 (Electronic)
IS  - 0730-9384 (Linking)
VI  - 31
IP  - 1-2
DP  - 2012 Spring-Fall
TI  - Public attitudes toward biofuels. Effects of knowledge, political partisanship,
      and media use.
PG  - 36-51
LID - 10.2990/31_1-2_36 [doi]
AB  - Despite large-scale investments and government mandates to expand biofuels
      development and infrastructure in the United States, little is known about how
      the public conceives of this alternative fuel technology. This study examines
      public opinion of biofuels by focusing on citizen knowledge and the motivated
      processing of media information. Specifically, we explore the direct effects of
      biofuels knowledge and the moderating effect of partisanship on the relationship 
      between media use and benefit vs. risk perceptions in the following four domains:
      environmental impacts, economic consequences, ethical/social implications, and
      political ramifications. Our results suggest that more knowledgeable respondents 
      see fewer benefits of biofuels relative to risks, and that Democrats and
      Republicans are affected differently by media use when forming opinions about
      biofuels. Among Democrats, greater attention to political media content leads to 
      a more favorable outlook toward the technology across several domains of
      interest, while among Republicans, an increase in attention to political content 
      has the opposite effect. Possible reasons for these results, as well as
      implications of the findings at the intersection of politics and the life
      sciences, are discussed.
FAU - Cacciatore, Michael A
AU  - Cacciatore MA
AD  - Department of Life Sciences Communication, University of Wisconsin-Madison, 1545 
      Observatory Drive, Hiram Smith Hall 307, Madison, WI 53706, USA.
      mcacciatore@wisc.edu
FAU - Binder, Andrew R
AU  - Binder AR
FAU - Scheufele, Dietram A
AU  - Scheufele DA
FAU - Shaw, Bret R
AU  - Shaw BR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Politics Life Sci
JT  - Politics and the life sciences : the journal of the Association for Politics and 
      the Life Sciences
JID - 8800535
RN  - 0 (Biofuels)
SB  - IM
MH  - *Biofuels
MH  - Humans
MH  - Knowledge
MH  - Mass Media
MH  - *Politics
MH  - *Public Opinion
MH  - United States
EDAT- 2013/02/06 06:00
MHDA- 2014/01/10 06:00
CRDT- 2013/02/06 06:00
PHST- 2013/02/06 06:00 [entrez]
PHST- 2013/02/06 06:00 [pubmed]
PHST- 2014/01/10 06:00 [medline]
AID - 10.2990/31_1-2_36 [doi]
PST - ppublish
SO  - Politics Life Sci. 2012 Spring-Fall;31(1-2):36-51. doi: 10.2990/31_1-2_36.


PMID- 23378684
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130205
LR  - 20220408
IS  - 0353-8109 (Print)
IS  - 0353-8109 (Linking)
VI  - 20
IP  - 4
DP  - 2012 Dec
TI  - Plagiarism in scientific publishing.
PG  - 208-13
LID - 10.5455/aim.2012.20.208-213 [doi]
AB  - Scientific publishing is the ultimate product of scientist work. Number of
      publications and their quoting are measures of scientist success while
      unpublished researches are invisible to the scientific community, and as such
      nonexistent. Researchers in their work rely on their predecessors, while the
      extent of use of one scientist work, as a source for the work of other authors is
      the verification of its contributions to the growth of human knowledge. If the
      author has published an article in a scientific journal it cannot publish the
      article in any other journal h with a few minor adjustments or without quoting
      parts of the first article, which are used in another article. Copyright
      infringement occurs when the author of a new article with or without the
      mentioning the author used substantial portions of previously published articles,
      including tables and figures. Scientific institutions and universities should,in 
      accordance with the principles of Good Scientific Practice (GSP) and Good
      Laboratory Practices (GLP) have a center for monitoring,security, promotion and
      development of quality research. Establish rules and compliance to rules of good 
      scientific practice are the obligations of each research
      institutions,universities and every individual-researchers,regardless of which
      area of science is investigated. In this way, internal quality control ensures
      that a research institution such as a university, assume responsibility for
      creating an environment that promotes standards of excellence, intellectual
      honesty and legality. Although the truth should be the aim of scientific
      research, it is not guiding fact for all scientists. The best way to reach the
      truth in its study and to avoid the methodological and ethical mistakes is to
      consistently apply scientific methods and ethical standards in research. Although
      variously defined plagiarism is basically intended to deceive the reader's own
      scientific contribution. There is no general regulation of control of scientific 
      research and intellectual honesty of researchers which would be absolutely
      applicable in all situations and in all research institutions. A special form of 
      plagiarism is self-plagiarism. Scientists need to take into consideration this
      form of plagiarism, though for now there is an attitude as much as their own
      words can be used without the word about plagiarism. If the authors cite their
      own research facilities already stated then they should be put in quote sand cite
      the source in which it was published. Science should not be exempt from
      disclosure and sanctioning plagiarism. In the fight against intellectual
      dishonesty on ethics education in science has a significant place. A general
      understanding of ethics in scientific research work in all its stages had to be
      acquired during the undergraduate course and continue to intensify. It is also
      important ethical aspect of the publishing industry,especially in small and
      developing economies,because the issuer has an educational role in the
      development of the scientific community that aspires to relish so. In this paper 
      author describe his experiences in discovering of plagiarism as Editor-in-Chief
      of three indexed medical journals with presentations of several examples of
      plagiarism recorded in countries in Southeastern Europe.
FAU - Masic, Izet
AU  - Masic I
AD  - Faculty of medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
LA  - eng
PT  - Journal Article
PL  - Bosnia and Herzegovina
TA  - Acta Inform Med
JT  - Acta informatica medica : AIM : journal of the Society for Medical Informatics of
      Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH
JID - 101147064
PMC - PMC3558294
OTO - NOTNLM
OT  - ethical dilemmas
OT  - medical journals
OT  - plagiarism
OT  - scientific publishing
OT  - self-plagiarism.
EDAT- 2013/02/05 06:00
MHDA- 2013/02/05 06:01
CRDT- 2013/02/05 06:00
PHST- 2012/09/15 00:00 [received]
PHST- 2012/11/30 00:00 [accepted]
PHST- 2013/02/05 06:00 [entrez]
PHST- 2013/02/05 06:00 [pubmed]
PHST- 2013/02/05 06:01 [medline]
AID - 10.5455/aim.2012.20.208-213 [doi]
AID - AIM-20-208 [pii]
PST - ppublish
SO  - Acta Inform Med. 2012 Dec;20(4):208-13. doi: 10.5455/aim.2012.20.208-213.


PMID- 23378397
OWN - NLM
STAT- MEDLINE
DCOM- 20130404
LR  - 20151119
VI  - 16
IP  - 3
DP  - 2012 Jul-Sep
TI  - [Effect of cigarette smoking on blood lead levels in pregnant women].
PG  - 196-204
AB  - UNLABELLED: Tobacco smoking creates health problems which apply not only to
      individuals and the family but also to different ages and social groups, as well 
      as the national economy. Epidemiologic studies conducted at the Institute of
      Mother and Child indicated that in Poland 25-30% women smoke during pregnancy.
      Lead exposure from cigarette smoke may have a negative effect on the
      transplacental flow of micronutrients and have an adverse influence on the growth
      and development of the fetus, and then on children. The aim of this study was to 
      estimate the effect of smoking cigarettes on plasma and whole blood lead levels
      in pregnant women. MATERIAL AND METHODS: Eighty healthy pregnant women, patients 
      of the Clinical Department of the Obstetrics and Gynecology Institute of Mother
      and Child and Warsaw Medical University, were divided into two groups: group I - 
      tobacco smokers and group II- tobacco abstainers according to questionnaire
      declaration and serum cotinine concentration. Current smokers were defined as
      those who had smoked 5 cigarettes per day for 2 years before conception and
      continued smoking during pregnancy. The women exposed to environmental tobacco
      smoke (smoking spouse or other family members, co-workers) were excluded from the
      non-smoking group. All pregnant volunteers signed a written, informed consent
      form, approved by the Institute's Ethical Committee. The concentrations of lead
      in plasma and whole blood were analyzed using inductively coupled plasma mass
      spectrometry on spectrometer analyzer ICP MS Elan 6100 (Perking Elmer, Germany). 
      Levels of cotinine in serum were determined by Cotinine Direct ELISA test
      (Calbiotech Inc. Canada). RESULTS: In the group of smoking mothers the mean serum
      cotinine concentration was 69.1 mug/L, whereas in the group of tobacco abstainers
      it was present only in trace amount. In group I we observed a significant
      positive correlation between serum cotinine and the number of cigarettes smoked
      daily (r=0.74; p<0.001), as well as the period of smoking before conception
      (r=0.60; p<0.001). The concentrations of lead in the plasma of smoking women were
      significantly higher than in the group of tobacco abstainers in each trimester of
      pregnancy (I trimester: 0.22 mug/dL vs 0.12 mug/dL p<0.01; II trimester: 0.19
      mug/L vs 0.10 mug/L p<0.001; III trimester 0.28 mug/ dL vs 0.13 mug/dL p<0.0001).
      Tobacco smoking mothers also had a higher concentration of lead in whole blood as
      compared to pregnant non-smoking women. These differences were statistically
      significant and amounted to 2.15 mug/dL vs 1.28 mug/L in the first, 1.99 mug/dL
      vs 1.19 mug/dL in the second and 2.11 mug/dL vs 1.58 mug/dL in the third
      trimester of pregnancy. We observed that the level of lead was correlated with
      cotinine in blood, as well as with the number of cigarettes and the length of
      time women smoked before conception. Such an effect was observed in every
      trimester of gestation. A strong correlation between the number of cigarettes/day
      and lead concentration in plasma (r=0.57; p<0.001) and whole blood (r=0.54;
      p<0.001) was found in the third trimester of pregnancy. CONCLUSIONS: Tobacco
      smoking during pregnancy increased the concentrations in maternal blood lead. The
      level of lead in plasma and whole blood correlated with the degree of intensity
      of cigarette smoking in the pregnant women studied. It may be a result of
      influencing the mobilization of calcium from the bone with simultaneous release
      of lead deposited in the bone. Further studies are required to characterize the
      effect of higher lead level in the blood of mothers on the risk of premature
      labor, low birth weight of newborns and their inferior development.
FAU - Chelchowska, Magdalena
AU  - Chelchowska M
AD  - Zaklad Badan Przesiewowych, Instytut Matki i Dziecka, ul. Kasprzaka 17A, 01-211
      Warszawa. lipid.imid@imid.med.pl
FAU - Jablonka-Salach, Katarzyna
AU  - Jablonka-Salach K
FAU - Ambroszkiewicz, Jadwiga
AU  - Ambroszkiewicz J
FAU - Maciejewski, Tomasz
AU  - Maciejewski T
FAU - Gajewska, Joanna
AU  - Gajewska J
FAU - Bulska, Ewa
AU  - Bulska E
FAU - Laskowska-Klita, Teresa
AU  - Laskowska-Klita T
FAU - Leibschang, Jerzy
AU  - Leibschang J
FAU - Barciszewski, Jan
AU  - Barciszewski J
LA  - pol
PT  - Controlled Clinical Trial
PT  - English Abstract
PT  - Journal Article
TT  - Wplyw palenia tytoniu na poziom olowiu we KRWI kobiet ciezarnych.
PL  - Poland
TA  - Med Wieku Rozwoj
JT  - Medycyna wieku rozwojowego
JID - 100928610
RN  - 0 (Tobacco Smoke Pollution)
RN  - 2P299V784P (Lead)
RN  - K5161X06LL (Cotinine)
SB  - IM
MH  - Adult
MH  - Cotinine/*blood
MH  - Environmental Monitoring
MH  - Female
MH  - Humans
MH  - Lead/*blood
MH  - Poland
MH  - Pregnancy
MH  - Pregnancy Complications/*blood
MH  - Pregnancy Trimester, Third
MH  - Smoking/*blood
MH  - Surveys and Questionnaires
MH  - Tobacco Smoke Pollution/*analysis
MH  - Young Adult
EDAT- 2013/02/05 06:00
MHDA- 2013/04/05 06:00
CRDT- 2013/02/05 06:00
PHST- 2013/02/05 06:00 [entrez]
PHST- 2013/02/05 06:00 [pubmed]
PHST- 2013/04/05 06:00 [medline]
PST - ppublish
SO  - Med Wieku Rozwoj. 2012 Jul-Sep;16(3):196-204.


PMID- 23374379
OWN - NLM
STAT- MEDLINE
DCOM- 20130726
LR  - 20180126
IS  - 2444-054X (Electronic)
IS  - 0009-7411 (Linking)
VI  - 80
IP  - 4
DP  - 2012 Jul-Aug
TI  - [Standardizing a central nervous system tumor DNA biobank].
PG  - 327-32
AB  - BACKGROUND: Brain tumors are one of the leading cancers worldwide; in the
      National Institute of Neurology and Neurosurgery (INNN) these tumors are the
      leading cause of morbitity and mortality. OBJECTIVE: Standardize biopsies,
      colletion, processing and storage biologic material of molecular studies.
      METHODS: with a previously signed surgical consent, a tumor and blood biopsy was 
      done to 134 patients. Their DNA was extracted and a database was filled
      considering technical, ethical and legal aspects. In order to have optimal
      biologic material the procedure was standardized between the surgical and
      research laboratory teams. RESULTS: The biopsy, transportation, processing and
      storage were standardized. 134 patients were included (67 male and 67 female)
      with an average age of 46.28 years (range 15-81). The most frequently biopsied
      tumor was the meningioma (42%). The integrity of the obtained material was
      determined by agarose gel electrophoretic analysis. CONCLUSION: the INNN biobank 
      has a standardized system that biopsies, processes and stores optimum quality
      biologic material that will be the basis of future molecular studies.
FAU - Mendez-Rosito, Diego
AU  - Mendez-Rosito D
AD  - Departamento de Neurocirugia, Instituto Nacional de Neurologia y Neurocirugia
      Manuel Velasco Suarez, La Fama, Tlalpan, Mexico, D.F., Mexico.
      diegomendezrosito@gmail.com
FAU - Rangel-Lopez, Edgar
AU  - Rangel-Lopez E
FAU - Aguirre-Cruz, Maria Lucinda
AU  - Aguirre-Cruz ML
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
TT  - Estandarizacion de un biobanco de ADN de tumores del sistema nervioso central.
PL  - Mexico
TA  - Cir Cir
JT  - Cirugia y cirujanos
JID - 0372736
RN  - 0 (DNA, Neoplasm)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biological Specimen Banks/organization & administration/*standards
MH  - Biopsy/standards
MH  - Central Nervous System/chemistry/pathology
MH  - Central Nervous System Neoplasms/chemistry/genetics/*pathology/secondary
MH  - Cranial Nerve Neoplasms/chemistry/genetics/pathology
MH  - *DNA, Neoplasm/analysis/genetics/isolation & purification
MH  - Databases, Factual
MH  - Electrophoresis, Agar Gel
MH  - Female
MH  - Humans
MH  - Male
MH  - Meningioma/chemistry/genetics/*pathology
MH  - Mexico
MH  - Middle Aged
MH  - Neoplasms, Neuroepithelial/chemistry/genetics/*pathology
MH  - Peripheral Nervous System Neoplasms/chemistry/genetics/pathology
MH  - Preservation, Biological/methods/standards
MH  - Quality Assurance, Health Care
MH  - Specimen Handling/standards
MH  - Spinal Nerves/chemistry/pathology
MH  - Transportation/standards
MH  - Young Adult
EDAT- 2013/02/05 06:00
MHDA- 2013/07/28 06:00
CRDT- 2013/02/05 06:00
PHST- 2013/02/05 06:00 [entrez]
PHST- 2013/02/05 06:00 [pubmed]
PHST- 2013/07/28 06:00 [medline]
PST - ppublish
SO  - Cir Cir. 2012 Jul-Aug;80(4):327-32.


PMID- 23374302
OWN - NLM
STAT- MEDLINE
DCOM- 20130402
LR  - 20181023
IS  - 0256-9574 (Print)
VI  - 103
IP  - 2
DP  - 2012 Nov 8
TI  - Analysis of time to regulatory and ethical approval of SATVI TB vaccine trials in
      South Africa.
PG  - 85-9
LID - 10.7196/samj.6390 [doi]
AB  - BACKGROUND: Tuberculosis (TB) vaccine trials in South Africa must be approved by 
      the Medicines Control Council (MCC) and by a human research ethics committee
      (HREC). Delays in regulatory and ethical approval may affect operational and
      budget planning and clinical development of the product. AIM: Our aim was to
      analyse the time to regulatory and ethical approval for TB vaccine trials
      conducted by the South African Tuberculosis Vaccine Initiative (SATVI) and to
      evaluate factors that influence time to final approval. METHOD: Sixteen new TB
      vaccine clinical trials conducted by SATVI between 2004 and 2012 on infants,
      children, and adults were included. The period between submission and final
      approval was determined for protocols submitted to the MCC and the University of 
      Cape Town HREC. RESULTS: Median approval time following first submission to the
      MCC was 122 days (IQR 112 - 168; range 71 - 350), and for protocol amendments 103
      days (interquartile range (IQR) 76 - 141; range 23 - 191; n=30). Median time
      following first submission for HREC approval was 60 days (IQR 33 - 81; range 18 -
      125), and for amendments 6 days (IQR 4 - 13; range 1 - 37; n=30). There was no
      significant difference in approval time by trial phase, year of submission,
      revisions required, study population, sample size, or whether a clinical research
      organisation (CRO) was used. CONCLUSION: The time needed for regulatory and
      ethics approval was highly variable, but MCC approval for first submissions took 
      twice as long as HREC approval and was the primary determinant of time to final
      approval. National regulatory capacity should be strengthened to facilitate the
      conduct of new TB vaccine trials in this country with its high burden of TB.
FAU - Geldenhuys, H
AU  - Geldenhuys H
AD  - South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious
      Disease and Molecular Medicine (IIDMM), University of Cape Town, South Africa.
      hennie.geldenhuys@uct.ac.za
FAU - Veldsman, A
AU  - Veldsman A
FAU - Tameris, M
AU  - Tameris M
FAU - Luabeya, A
AU  - Luabeya A
FAU - Hanekom, W
AU  - Hanekom W
FAU - Mahomed, H
AU  - Mahomed H
FAU - Hatherill, M
AU  - Hatherill M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20121108
PL  - South Africa
TA  - S Afr Med J
JT  - South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
JID - 0404520
RN  - 0 (Tuberculosis Vaccines)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Clinical Trials as Topic/*ethics
MH  - Ethics Committees, Research/*statistics & numerical data
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Morbidity/trends
MH  - South Africa/epidemiology
MH  - Time Factors
MH  - Tuberculosis/epidemiology/*prevention & control
MH  - Tuberculosis Vaccines/*pharmacology
MH  - Young Adult
EDAT- 2013/02/05 06:00
MHDA- 2013/04/03 06:00
CRDT- 2013/02/05 06:00
PHST- 2012/10/10 00:00 [received]
PHST- 2012/10/16 00:00 [accepted]
PHST- 2013/02/05 06:00 [entrez]
PHST- 2013/02/05 06:00 [pubmed]
PHST- 2013/04/03 06:00 [medline]
AID - 10.7196/samj.6390 [doi]
PST - epublish
SO  - S Afr Med J. 2012 Nov 8;103(2):85-9. doi: 10.7196/samj.6390.


PMID- 23373344
OWN - NLM
STAT- MEDLINE
DCOM- 20130226
LR  - 20161020
IS  - 0869-866X (Print)
IS  - 0869-866X (Linking)
IP  - 4
DP  - 2012 Jul-Aug
TI  - [On the role of the state-private partnership in public health].
PG  - 41-3
AB  - The article deals with the issues of study of state-private partnership in the
      framework of development of strategic measures of regulation of this area in
      public health. It is demonstrated that the regulation of state-private
      partnership has to combine the dynamism inherent in entrepreneurship and the
      public stability needed for normal public health functioning. The control
      functions of state authorities in the area of public health policy developed into
      concept of "supervision" which obligates the state to manage the health system
      guided by norms of ethics and financial expediency. The regulation as a main tool
      of "supervision" in the state-private partnership has to meet the same two
      requirements. The activation of entrepreneur activity in public health by no
      means is caused by increase of privatization in this sector. Under these
      conditions, the implementation of market mechanisms in public health system make 
      is more effective and efficient.
FAU - Nechaev, V S
AU  - Nechaev VS
FAU - Nisan, B A
AU  - Nisan BA
LA  - rus
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Russia (Federation)
TA  - Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med
JT  - Problemy sotsial'noi gigieny, zdravookhraneniia i istorii meditsiny
JID - 101270373
SB  - IM
MH  - *Entrepreneurship
MH  - Humans
MH  - Private Sector/*organization & administration
MH  - *Public Health
MH  - Public Policy/*legislation & jurisprudence
MH  - Russia
EDAT- 2013/02/05 06:00
MHDA- 2013/02/27 06:00
CRDT- 2013/02/05 06:00
PHST- 2013/02/05 06:00 [entrez]
PHST- 2013/02/05 06:00 [pubmed]
PHST- 2013/02/27 06:00 [medline]
PST - ppublish
SO  - Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med. 2012 Jul-Aug;(4):41-3.


PMID- 23373306
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20191112
IS  - 0028-2200 (Print)
IS  - 0028-2200 (Linking)
VI  - 119
IP  - 12
DP  - 2012 Dec
TI  - [Medico-ethical considerations when indicating single-tooth fixed prosthesis,
      multi-teeth fixed prosthesis, and oral implants].
PG  - 611-9
AB  - The question whether a patient needs extensive and invasive treatment, such as
      single-tooth fixed prosthesis, multi-teeth fixed prosthesis or oral implants, can
      be established only in a dialogue with mutual respect between the healthcare
      provider and the patient. With respect to this question, the following principles
      have to be considered: the patient's autonomy, beneficence, non-maleficence, and 
      justice. These principles are reflected in legislation and are implicitly applied
      in complaint and disciplinary jurisdiction. When the autonomy of a patient is not
      sufficiently respected by a healthcare provider, a patient complaint might be the
      result, such as a complaint of impertinent treatment, lack of informed consent,
      or poor patient documentation. If beneficence or non-maleficence principles are
      violated, an intrinsic treatment complaint might be the result, such as a
      complaint of inadequate treatment planning, often based on inadequate
      examination, and complications or untimely failure of single-tooth fixed
      prosthesis, multi-teeth fixed prosthesis or oral implants. Respecting the
      previously mentioned principles promotes appropriate healthcare to the patient
      also in complex care with other healthcare providers.
FAU - Witter, D J
AU  - Witter DJ
AD  - vakgroep Orale Functie en Prothetische Tandheelkunde van het Universitair Medisch
      Centrum St Radboud in Nijmegen.
FAU - Brands, W G
AU  - Brands WG
FAU - Hoefnagel, R A
AU  - Hoefnagel RA
FAU - Creugers, N H J
AU  - Creugers NH
LA  - dut
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Medisch-ethische overwegingen bij de indicatie van kronen, bruggen en
      implantaten.
PL  - Netherlands
TA  - Ned Tijdschr Tandheelkd
JT  - Nederlands tijdschrift voor tandheelkunde
JID - 0400771
MH  - Communication
MH  - Dental Implantation, Endosseous
MH  - *Dental Implants, Single-Tooth
MH  - *Dentist-Patient Relations
MH  - Denture, Partial, Fixed
MH  - Humans
MH  - Jaw, Edentulous, Partially/*rehabilitation
MH  - Patient Satisfaction
MH  - *Personal Autonomy
EDAT- 2013/02/05 06:00
MHDA- 2013/02/13 06:00
CRDT- 2013/02/05 06:00
PHST- 2013/02/05 06:00 [entrez]
PHST- 2013/02/05 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
AID - 10.5177/ntvt.2012.12.12244 [doi]
PST - ppublish
SO  - Ned Tijdschr Tandheelkd. 2012 Dec;119(12):611-9. doi: 10.5177/ntvt.2012.12.12244.


PMID- 23373038
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130204
LR  - 20211021
IS  - 2249-782X (Print)
IS  - 0973-709X (Linking)
VI  - 6
IP  - 10
DP  - 2012 Dec
TI  - Congenital malformations in perinatal autopsies - a study of 100 cases.
PG  - 1726-30
LID - 10.7860/JCDR/2012/4686.2651 [doi]
AB  - BACKGROUND: Congenital malformations remain a common cause of perinatal deaths
      and even though ultrasonogram can give fairly accurate diagnosis, perinatal
      autopsy is essential to confirm the diagnosis and look for associated
      malformations. OBJECTIVES: To emphasize the importance of perinatal autopsy in
      diagnosing congenital malformations and to compare the same with the prenatal
      ultrasound findings. METHODS: The present study comprises 100 consecutive
      perinatal autopsies conducted after obtaining the approval from the Institutional
      Ethics Committee. In cases where prenatal ultrasound findings were available they
      were compared with the autopsy findings. RESULTS: Out of 100 perinatal autopsies,
      44 cases were congenital anomalies with M:F = 1:1.5. Majority of the fetuses with
      congenital malformations (36.36%) were therapeutically terminated, Cental nervous
      system malformations being the commonest indication. The most common timing of
      therapeutic termination being 20 -24weeks. Congenital malformations were common
      between 35-39 weeks gestational age and birth weight range 350- 1000g. The
      malformations involving the central nervous system were commonest, seen in 15
      cases (34.09%) followed by renal anomalies in 9 cases (20.45%) and multiple
      malformations in 7cases ( 15.91%). Autopsy confirmed the prenatal ultrasound
      findings in 50% of the cases, added to diagnosis in 29.54%, while it completely
      changed the primary diagnosis in 9.09% of the cases. CONCLUSION: This study
      highlights the importance of perinatal autopsy in confirming the diagnosis of
      congenital anomalies by prenatal ultrasound findings.
FAU - Andola, Uma S
AU  - Andola US
AD  - Professor, Department of Obstetrics and Gynecology, MR Medical College and
      Basaveshwar Teaching and General Hospital , Gulbarga, Karnataka, India.
FAU - Am, Anita
AU  - Am A
FAU - Ahuja, Mukta
AU  - Ahuja M
FAU - Andola, Sainath K
AU  - Andola SK
LA  - eng
PT  - Journal Article
DEP - 20121122
PL  - India
TA  - J Clin Diagn Res
JT  - Journal of clinical and diagnostic research : JCDR
JID - 101488993
PMC - PMC3552214
OTO - NOTNLM
OT  - Congenital malformations
OT  - Perinatal autopsy
OT  - Prenatal ultrasound
EDAT- 2013/02/02 06:00
MHDA- 2013/02/02 06:01
CRDT- 2013/02/02 06:00
PHST- 2012/06/11 00:00 [received]
PHST- 2012/10/14 00:00 [accepted]
PHST- 2013/02/02 06:00 [entrez]
PHST- 2013/02/02 06:00 [pubmed]
PHST- 2013/02/02 06:01 [medline]
AID - 10.7860/JCDR/2012/4686.2651 [doi]
PST - ppublish
SO  - J Clin Diagn Res. 2012 Dec;6(10):1726-30. doi: 10.7860/JCDR/2012/4686.2651. Epub 
      2012 Nov 22.


PMID- 23372188
OWN - NLM
STAT- MEDLINE
DCOM- 20130319
LR  - 20211021
IS  - 0008-5286 (Print)
IS  - 0008-5286 (Linking)
VI  - 53
IP  - 8
DP  - 2012 Aug
TI  - Veterinary medical ethics: an ethicist's commentary on the veterinarian facing a 
      human respiratory emergency.
PG  - 823-6
FAU - Rollin, Bernard E
AU  - Rollin BE
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Vet J
JT  - The Canadian veterinary journal = La revue veterinaire canadienne
JID - 0004653
SB  - IM
CIN - Can Vet J. 2013 Jan;54(1):10. PMID: 23814294
MH  - Animals
MH  - Canada
MH  - Emergency Medical Services/*ethics
MH  - *Ethics, Clinical
MH  - Humans
MH  - *Legislation, Veterinary
MH  - *Morals
MH  - Veterinarians/*ethics/*psychology
MH  - Veterinary Medicine
PMC - PMC3398517
EDAT- 2013/02/02 06:00
MHDA- 2013/03/21 06:00
CRDT- 2013/02/02 06:00
PHST- 2013/02/02 06:00 [entrez]
PHST- 2013/02/02 06:00 [pubmed]
PHST- 2013/03/21 06:00 [medline]
PST - ppublish
SO  - Can Vet J. 2012 Aug;53(8):823-6.


PMID- 23369501
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130204
LR  - 20211021
IS  - 2001-1326 (Print)
IS  - 2001-1326 (Linking)
VI  - 1
IP  - 1
DP  - 2012 May 31
TI  - Understanding drug uptake and binding within targeted disease micro-environments 
      in patients: a new tool for translational medicine.
PG  - 8
LID - 10.1186/2001-1326-1-8 [doi]
AB  - UNLABELLED: BACKGROUND: For many common global diseases, such as cancer,
      diabetes, neurodegenerative and cardiovascular diseases there is an unmet need
      for diagnosing early indications of disease that could enable medical
      intervention and early treatment. The treatment of these diseases will require
      detailed knowledge of targeted pathways involved in disease pathogenesis but also
      the mode of drug actions at the biological location on these targets.
      Translational medicine is a new area of research where expert from different
      disciplines involved in basic science and clinical disciplines meet and join
      forces. Mode-of-drug-action mechanisms elucidation is key in the characterization
      of drugs that can relate to both efficacy and safety. METHODS: Matrix assisted
      laser desorption/ionization mass spectrometry imaging (MALDI-MSI) was used
      providing evidence into the fate (destinations and distributions) of administered
      drugs within tumor regions of lung compartments. RESULTS: We hereby present a
      pulmonary study in which we have isolated lung tissue after inhaled drug
      administration and then localized the drug within airway wall compartments. The
      histology also provides evidence of drug binding to smooth muscle cell
      microenvironments. We also identified lung tissue regions with tumor cell
      invasion in these COPD patients. CONCLUSIONS: The ultimate goal is to identify
      bridging comprehension that forms a knowledge base that can be used by society to
      develop a better treatment and medicine for patients. Our results demonstrated
      that robust imaging data could be generated confirming drug localization in
      pulmonary regions of COPD patients with tumor pathology. TRIAL REGISTRATION:
      Tallinn Medical Research Ethical Committee decision #1724, 18.06.2009.
FAU - Marko-Varga, Gyorgy
AU  - Marko-Varga G
AD  - Clinical Protein Science & Imaging, Biomedical Center, Dept, of Measurement
      Technology and Industrial Electrical Engineering, Lund University, BMC C13,
      SE-221 84, Lund, Sweden. Gyorgy.Marko-Varga@elmat.lth.se.
FAU - Vegvari, Akos
AU  - Vegvari A
FAU - Rezeli, Melinda
AU  - Rezeli M
FAU - Prikk, Kaiu
AU  - Prikk K
FAU - Ross, Peeter
AU  - Ross P
FAU - Dahlback, Magnus
AU  - Dahlback M
FAU - Edula, Goutham
AU  - Edula G
FAU - Sepper, Ruth
AU  - Sepper R
FAU - Fehniger, Thomas E
AU  - Fehniger TE
LA  - eng
PT  - Journal Article
DEP - 20120531
PL  - United States
TA  - Clin Transl Med
JT  - Clinical and translational medicine
JID - 101597971
PMC - PMC3560985
EDAT- 2013/02/02 06:00
MHDA- 2013/02/02 06:01
CRDT- 2013/02/02 06:00
PHST- 2012/04/06 00:00 [received]
PHST- 2012/04/30 00:00 [accepted]
PHST- 2013/02/02 06:00 [entrez]
PHST- 2013/02/02 06:00 [pubmed]
PHST- 2013/02/02 06:01 [medline]
AID - 2001-1326-1-8 [pii]
AID - 10.1186/2001-1326-1-8 [doi]
PST - epublish
SO  - Clin Transl Med. 2012 May 31;1(1):8. doi: 10.1186/2001-1326-1-8.


PMID- 23367749
OWN - NLM
STAT- MEDLINE
DCOM- 20130215
LR  - 20130201
IS  - 0017-7768 (Print)
IS  - 0017-7768 (Linking)
VI  - 151
IP  - 9
DP  - 2012 Sep
TI  - [Telling the truth to Alzheimer and dementia patients in the early stages of the 
      disease].
PG  - 537-40, 555
AB  - Disclosing the diagnosis of Alzheimer's disease to the patient is emotionally
      difficult and ethically challenging. Arguments against telling the truth include:
      diagnostic uncertainty, patient's inability to understand the diagnosis,
      patient's unwillingness to recognize the diagnosis, potential negative social
      implications, unpredictable emotional reactions and losing hope. Arguments in
      favor of truth telling include: patient autonomy, relations with the physician
      based on trust, emotional adaptation, future planning and support for the
      patients and their family. Current research in Western countries indicates that
      most patients of all ages wish to know their diagnosis, whereas many relatives
      and physicians believe that they should conceal it from the patient. Many
      physicians experience difficulties in delivering the diagnosis to the patient.
      Studies show that less than half of them reveal the diagnosis to the patient and 
      rarely discuss the prognosis, even though they convey this information to the
      relatives. Patients' reactions to the diagnosis of Alzheimer's disease is
      influenced by the way it is delivered, the patients' emotional vulnerability,
      coping style and past experience with dementia. Reactions vary from denial,
      anger, fear, sorrow and depression to positive coping. The proper question is how
      to disclose the diagnosis and not whether it should be told. Disclosing the
      diagnosis is a complicated and dynamic process that should begin when there is
      suspicion of a cognitive decline. It demands physician sensitivity flexibility
      and discretion. Discussing the diagnosis in time enables the patient to be
      involved in treatment decisions and planning his or her future.
FAU - Ilan, Sara
AU  - Ilan S
AD  - The Faculty of Health Science, Ben-Gurion University of the Negev.
      sarailan@gmail.com
FAU - Glick, Shimon
AU  - Glick S
FAU - Jotkowitz, Alan Bruce
AU  - Jotkowitz AB
LA  - heb
PT  - English Abstract
PT  - Journal Article
PL  - Israel
TA  - Harefuah
JT  - Harefuah
JID - 0034351
SB  - IM
MH  - Alzheimer Disease/diagnosis/*psychology
MH  - Attitude to Health
MH  - Dementia/diagnosis/*psychology
MH  - Humans
MH  - Patient Participation
MH  - Personal Autonomy
MH  - Physician-Patient Relations
MH  - Prognosis
MH  - Trust
MH  - *Truth Disclosure
EDAT- 2013/02/02 06:00
MHDA- 2013/02/16 06:00
CRDT- 2013/02/02 06:00
PHST- 2013/02/02 06:00 [entrez]
PHST- 2013/02/02 06:00 [pubmed]
PHST- 2013/02/16 06:00 [medline]
PST - ppublish
SO  - Harefuah. 2012 Sep;151(9):537-40, 555.


PMID- 23367746
OWN - NLM
STAT- MEDLINE
DCOM- 20130215
LR  - 20130201
IS  - 0017-7768 (Print)
IS  - 0017-7768 (Linking)
VI  - 151
IP  - 9
DP  - 2012 Sep
TI  - [Ethical dilemma in research: informed consent in clinical studies on persons
      with dementia].
PG  - 525-8, 556
AB  - With the world's population aging, there is an increase in the number of demented
      elderly. It is vital to study this phenomenon in epidemiological and clinical
      studies, particularly the effects on the increasing numbers of demented elderly. 
      Researchers need to understand the factors predicting the general decline in the 
      demented elderly. However, before any research is undertaken, it is necessary to 
      obtain approval from the Local Internal Review Board. This committee is
      responsible to maintain accepted national and international ethical standards.
      The basis for recruitment to a study is the signature on the informed consent
      form, where the patient is required to understand the study, internalize the
      study's aim, to consider all options and finally, to express an opinion.
      Potential elderly participants need to have their judgment evaluated before
      signing the form. In cases where the subject is incapable, some countries,
      including Israel, require that there be a legal guardianship. This is a long and 
      complicated process that causes researchers not to recruit demented patients into
      a study which may actually be beneficial to all. Some countries allow a proxy to 
      sign informed consent forms to permit the demented subject to participate in the 
      study. Often the threshold may depend on the invasiveness of the intervention.
      The problem of proxies to sign informed consent form troubles researchers
      worldwide. This article addresses the history and development of ethics in
      research, and raises the issue to promote an official policy for proxy consent
      signing.
FAU - Sinoff, Gary
AU  - Sinoff G
AD  - Carmel Medical Center. GarySi@clalit.org.il
LA  - heb
PT  - English Abstract
PT  - Journal Article
PL  - Israel
TA  - Harefuah
JT  - Harefuah
JID - 0034351
SB  - IM
MH  - Aged
MH  - Clinical Trials as Topic/*ethics
MH  - Dementia/*physiopathology
MH  - *Ethics, Research
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Israel
MH  - Legal Guardians
MH  - Mental Competency
MH  - Patient Selection
MH  - Proxy
EDAT- 2013/02/02 06:00
MHDA- 2013/02/16 06:00
CRDT- 2013/02/02 06:00
PHST- 2013/02/02 06:00 [entrez]
PHST- 2013/02/02 06:00 [pubmed]
PHST- 2013/02/16 06:00 [medline]
PST - ppublish
SO  - Harefuah. 2012 Sep;151(9):525-8, 556.


PMID- 23367744
OWN - NLM
STAT- MEDLINE
DCOM- 20130215
LR  - 20130201
IS  - 0017-7768 (Print)
IS  - 0017-7768 (Linking)
VI  - 151
IP  - 9
DP  - 2012 Sep
TI  - [Raising the retirement age].
PG  - 520-1, 557, 556
AB  - Social legislation is an essential hallmark of a welfare state. A few years ago
      many countries in Europe were proud of the extent and depth of their social
      welfare policy, but, in the shadow of the continuing economic crisis during
      recent years, as part of other measures, they were obliged to rehabilitate the
      situation to cut social legislation. The retirement age is slowly rising,
      possibly climbing back to the age of 70, the age prescribed by Bismarck. It took 
      a century for European Leaders to realize that the "ideal" age to retire is 70.
      Bismarck's social legislation related well in anticipation of the future, a
      prescient sage. However, he was unable to guard his political position. He was
      forced to resign and retire from the political scene after a quarrel with Wilhelm
      II who approached the Social Democrats. So what he tried to do throughout those
      years was to oust the Social Democrats from the law. Finally the tables turned as
      he was forced to resign. Our Sages--our ancestors quoted: "Because you drowned
      others, they drowned you; and those that drowned you will eventually be drowned",
      Ethics of the Fathers (Mishnah Pirkei Avot, 2, 7).
FAU - Barel, Meir
AU  - Barel M
LA  - heb
PT  - Editorial
PT  - English Abstract
PL  - Israel
TA  - Harefuah
JT  - Harefuah
JID - 0034351
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Eligibility Determination
MH  - Europe
MH  - Humans
MH  - Public Policy
MH  - Retirement/*legislation & jurisprudence
MH  - Social Welfare/*legislation & jurisprudence
EDAT- 2013/02/02 06:00
MHDA- 2013/02/16 06:00
CRDT- 2013/02/02 06:00
PHST- 2013/02/02 06:00 [entrez]
PHST- 2013/02/02 06:00 [pubmed]
PHST- 2013/02/16 06:00 [medline]
PST - ppublish
SO  - Harefuah. 2012 Sep;151(9):520-1, 557, 556.


PMID- 23367738
OWN - NLM
STAT- MEDLINE
DCOM- 20130215
LR  - 20130201
IS  - 0017-7768 (Print)
IS  - 0017-7768 (Linking)
VI  - 151
IP  - 11
DP  - 2012 Nov
TI  - [How to submit a request for a clinical study to the ethics committee?].
PG  - 644-6
FAU - Tirosh, N
AU  - Tirosh N
FAU - Ashkenazi, S
AU  - Ashkenazi S
FAU - Lahav, M
AU  - Lahav M
LA  - heb
PT  - Journal Article
PL  - Israel
TA  - Harefuah
JT  - Harefuah
JID - 0034351
SB  - IM
MH  - Clinical Trials as Topic/*methods
MH  - *Ethics Committees, Research
MH  - Humans
MH  - *Research Design
EDAT- 2013/02/02 06:00
MHDA- 2013/02/16 06:00
CRDT- 2013/02/02 06:00
PHST- 2013/02/02 06:00 [entrez]
PHST- 2013/02/02 06:00 [pubmed]
PHST- 2013/02/16 06:00 [medline]
PST - ppublish
SO  - Harefuah. 2012 Nov;151(11):644-6.


PMID- 23367233
OWN - NLM
STAT- MEDLINE
DCOM- 20130730
LR  - 20200928
IS  - 2694-0604 (Electronic)
IS  - 2375-7477 (Linking)
VI  - 2012
DP  - 2012
TI  - New implantable therapeutic device for the control of an atrial fibrillation
      attack using the Peltier element.
PG  - 5741-4
LID - 10.1109/EMBC.2012.6347298 [doi]
AB  - For the development of the new therapeutic device for the atrial fibrillation,
      implantable cooling device using Peltier element was developed in this study. An 
      implantable cooling device had been consisted from Peltier element with
      transcutaneous energy transmission system (TETS). 1st coil can be contacted from 
      outside of the body, when the patients will feel palpitation. Electrical current 
      will be induced to the implanted 2nd coil. Peltier element will able to cool the 
      surface of the atrium. For the confirmation of the effect of the cooling device, 
      trial manufacture model was developed. Animal experiments using six healthy adult
      goats after animal ethical committee allowance was carried out. Fourth
      intercostals space had been opened after anesthesia inhalation, and various
      sensors had been inserted. AF was induced by the electrical current with battery.
      As the results, AF had been recovered to the normal sinus rhythm after cooling in
      all six goats. So, this cooling system for the control of AF showed evident
      effect in these experiments. Smaller size cooling device has been under
      development aiming at totally implantable type. Catheter type cooling device for 
      the insertion by the use of fiber-scope type is now under planning for the
      clinical application. This new type device may be able to become good news for
      the patients with uncontrollable AF.
FAU - Yambe, Tomoyuki
AU  - Yambe T
AD  - Tohoku University, Sendai 980-8575, Japan. yambe@idac.tohoku.ac.jp
FAU - Sumiyoshi, Taketada
AU  - Sumiyoshi T
FAU - Koga, Chihiro
AU  - Koga C
FAU - Shiraishi, Yasuyuki
AU  - Shiraishi Y
FAU - Miura, Hidekazu
AU  - Miura H
FAU - Sugita, Norihiro
AU  - Sugita N
FAU - Tanaka, Akira
AU  - Tanaka A
FAU - Yoshizawa, Makoto
AU  - Yoshizawa M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Annu Int Conf IEEE Eng Med Biol Soc
JT  - Annual International Conference of the IEEE Engineering in Medicine and Biology
      Society. IEEE Engineering in Medicine and Biology Society. Annual International
      Conference
JID - 101763872
SB  - IM
MH  - Animals
MH  - Atrial Fibrillation/*prevention & control
MH  - Goats
MH  - *Prostheses and Implants
EDAT- 2013/02/01 06:00
MHDA- 2013/07/31 06:00
CRDT- 2013/02/01 06:00
PHST- 2013/02/01 06:00 [entrez]
PHST- 2013/02/01 06:00 [pubmed]
PHST- 2013/07/31 06:00 [medline]
AID - 10.1109/EMBC.2012.6347298 [doi]
PST - ppublish
SO  - Annu Int Conf IEEE Eng Med Biol Soc. 2012;2012:5741-4. doi:
      10.1109/EMBC.2012.6347298.


PMID- 23366338
OWN - NLM
STAT- MEDLINE
DCOM- 20130801
LR  - 20200928
IS  - 2694-0604 (Electronic)
IS  - 2375-7477 (Linking)
VI  - 2012
DP  - 2012
TI  - Speech activity detection using accelerometer.
PG  - 2112-5
LID - 10.1109/EMBC.2012.6346377 [doi]
AB  - The level of social activity is linked to the overall wellbeing and to various
      disorders, including stress. In this regard, a myriad of automatic solutions for 
      monitoring social interactions have been proposed, usually including audio data
      analysis. Such approaches often face legal and ethical issues and they may also
      raise privacy concerns in monitored subjects thus affecting their natural
      behaviour. In this paper we present an accelerometer-based speech detection which
      does not require capturing sensitive data while being an easily applicable and a 
      cost-effective solution.
FAU - Matic, Aleksandar
AU  - Matic A
AD  - CREATE-NET, Trento, Italy.
FAU - Osmani, Venet
AU  - Osmani V
FAU - Mayora, Oscar
AU  - Mayora O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Annu Int Conf IEEE Eng Med Biol Soc
JT  - Annual International Conference of the IEEE Engineering in Medicine and Biology
      Society. IEEE Engineering in Medicine and Biology Society. Annual International
      Conference
JID - 101763872
SB  - IM
MH  - *Acceleration
MH  - Actigraphy/*instrumentation
MH  - Activities of Daily Living
MH  - Adult
MH  - Female
MH  - Humans
MH  - Male
MH  - Monitoring, Ambulatory/*instrumentation
MH  - Social Behavior
MH  - Sound Spectrography/instrumentation/*methods
MH  - Speech/*physiology
MH  - Speech Production Measurement/*instrumentation
MH  - Vocal Cords/*physiology
EDAT- 2013/02/01 06:00
MHDA- 2013/08/02 06:00
CRDT- 2013/02/01 06:00
PHST- 2013/02/01 06:00 [entrez]
PHST- 2013/02/01 06:00 [pubmed]
PHST- 2013/08/02 06:00 [medline]
AID - 10.1109/EMBC.2012.6346377 [doi]
PST - ppublish
SO  - Annu Int Conf IEEE Eng Med Biol Soc. 2012;2012:2112-5. doi:
      10.1109/EMBC.2012.6346377.


PMID- 23366103
OWN - NLM
STAT- MEDLINE
DCOM- 20130806
LR  - 20200928
IS  - 2694-0604 (Electronic)
IS  - 2375-7477 (Linking)
VI  - 2012
DP  - 2012
TI  - A neonatal thorax phantom for contact-less magnetic induction vitalparameter
      monitoring.
PG  - 1161-4
LID - 10.1109/EMBC.2012.6346142 [doi]
AB  - For contact-less monitoring of breathing and heart activity, magnetic induction
      measurements are applicable. For research and the development process of hardware
      and algorithms for parameter extraction, test cases are computer simulations,
      animal trials and, at the end, human trials. However, in the first development
      processes human trials are not suitable due to ethical reasons. Simliarly, animal
      trials may not be reasonable for only testing different amplifier approaches or
      basic testing of new coil configurations. There, computer simulations are the
      only available benchmarks but not suitable for every problem. In this article, we
      present a neonatal thorax phantom for emulation of lung and heart activity for
      magnetic induction systems as a test platform.
FAU - Cordes, Axel
AU  - Cordes A
AD  - Philips Chair for Medical Information Technology, RWTH Aachen University, Aachen,
      Germany. cordes@hia.rwth-aachen.de
FAU - Conzelmann, Nils
AU  - Conzelmann N
FAU - Leonhardt, Steffen
AU  - Leonhardt S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Annu Int Conf IEEE Eng Med Biol Soc
JT  - Annual International Conference of the IEEE Engineering in Medicine and Biology
      Society. IEEE Engineering in Medicine and Biology Society. Annual International
      Conference
JID - 101763872
SB  - IM
MH  - Animals
MH  - Computer Simulation
MH  - Female
MH  - Heart
MH  - *Heart Rate
MH  - Humans
MH  - Infant, Newborn
MH  - Lung
MH  - *Magnetic Fields
MH  - Male
MH  - Monitoring, Physiologic/*instrumentation/*methods
MH  - *Respiratory Rate
MH  - *Thorax
EDAT- 2013/02/01 06:00
MHDA- 2013/08/07 06:00
CRDT- 2013/02/01 06:00
PHST- 2013/02/01 06:00 [entrez]
PHST- 2013/02/01 06:00 [pubmed]
PHST- 2013/08/07 06:00 [medline]
AID - 10.1109/EMBC.2012.6346142 [doi]
PST - ppublish
SO  - Annu Int Conf IEEE Eng Med Biol Soc. 2012;2012:1161-4. doi:
      10.1109/EMBC.2012.6346142.


PMID- 23365567
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130201
LR  - 20211021
IS  - 1687-6423 (Electronic)
IS  - 1687-6415 (Linking)
VI  - 2012
DP  - 2012
TI  - Technological approaches to remote monitoring of elderly people in cardiology: a 
      usability perspective.
PG  - 104561
LID - 10.1155/2012/104561 [doi]
AB  - Moving from the experience gained in home telemonitoring of elderly patients with
      Congestive Heart Failure, that confirmed a reduction of the rehospitalization
      rate and an improved monitoring of drugs assumption by the patients, this paper
      extends the evaluation of technological approaches for remote health monitoring
      of older adults. Focus of the evaluation is on telemedicine effectiveness and
      usability, either from a patient's or a medical operator's perspective. The
      evaluation has been performed by testing three remote health platforms designed
      according to different technological approaches, in a realistic scenario
      involving older adults and medical operators (doctors and nurses). The aim of the
      testing activity was not to benchmark a specific solution with respect to the
      others, but to evaluate the main positive and negative issues related to the
      system and service design philosophy each solution was built upon. Though
      preliminary, the results discussed in the paper can be used as a set of
      guidelines in the selection of proper technological equipments for services
      targeted to elderly users, from a usability perspective. These results need to be
      complemented with more focused discussions of the ethical, medical, and legal
      aspects of the use of technology in remote healthcare.
FAU - Spinsante, Susanna
AU  - Spinsante S
AD  - Department of Information Engineering, Marche Polytechnic University, Via Brecce 
      Bianche 12, 60131 Ancona, Italy.
FAU - Antonicelli, Roberto
AU  - Antonicelli R
FAU - Mazzanti, Ilaria
AU  - Mazzanti I
FAU - Gambi, Ennio
AU  - Gambi E
LA  - eng
PT  - Journal Article
DEP - 20121206
PL  - Egypt
TA  - Int J Telemed Appl
JT  - International journal of telemedicine and applications
JID - 101467196
PMC - PMC3529419
EDAT- 2013/02/01 06:00
MHDA- 2013/02/01 06:01
CRDT- 2013/02/01 06:00
PHST- 2012/04/27 00:00 [received]
PHST- 2012/11/08 00:00 [accepted]
PHST- 2013/02/01 06:00 [entrez]
PHST- 2013/02/01 06:00 [pubmed]
PHST- 2013/02/01 06:01 [medline]
AID - 10.1155/2012/104561 [doi]
PST - ppublish
SO  - Int J Telemed Appl. 2012;2012:104561. doi: 10.1155/2012/104561. Epub 2012 Dec 6.


PMID- 23362610
OWN - NLM
STAT- MEDLINE
DCOM- 20130301
LR  - 20220321
IS  - 1322-7696 (Print)
IS  - 1322-7696 (Linking)
VI  - 19
IP  - 4
DP  - 2012
TI  - The role of clinical trial nurses: an Australian perspective.
PG  - 239-46
AB  - Over the past two decades, the number of clinical trials conducted globally has
      increased thereby increasing demand for nurses working as Clinical Trial Nurses
      (CTNs), sometimes known as Clinical Research Nurses. The role and professional
      issues for these nurses in Australia has not been empirically formulated.
      Sixty-seven clinical trial nurses were surveyed nationally using a modified
      version of the Clinical Trials Nursing Questionnaire (CTNQ). Findings revealed
      the complex CTN role can include the coordination of the trials on one or more
      sites. This involves all domains listed in the questionnaire from protocol
      development, ethics approval applications, recruitment and consenting of
      participants in trials, to administering or assisting with treatments within the 
      bounds of their practice code and the evaluation of protocols. Professional
      issues documented were: being undervalued in the nursing workforce, having no
      formal educational preparation for the role and minimal recognition in
      publications emanating from research in which they were involved. These nurses
      bring their practice knowledge to benefit research outcomes that may contribute
      to improving patient/client care.
FAU - Wilkes, Lesley
AU  - Wilkes L
AD  - School of Nursing and Midwifery, University of Western Sydney/Nepean, Blue
      Mountains Health District, Australia. l.wilkes@uws.edu.au
FAU - Jackson, Debra
AU  - Jackson D
FAU - Miranda, Charmaine
AU  - Miranda C
FAU - Watson, Roger
AU  - Watson R
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Collegian
JT  - Collegian (Royal College of Nursing, Australia)
JID - 9612493
MH  - Australia
MH  - Education, Nursing
MH  - Female
MH  - Health Care Surveys
MH  - Humans
MH  - Male
MH  - *Nurse's Role
MH  - *Nurses
MH  - *Research Personnel/education
MH  - Specialties, Nursing
EDAT- 2013/02/01 06:00
MHDA- 2013/03/02 06:00
CRDT- 2013/02/01 06:00
PHST- 2013/02/01 06:00 [entrez]
PHST- 2013/02/01 06:00 [pubmed]
PHST- 2013/03/02 06:00 [medline]
AID - 10.1016/j.colegn.2012.02.005 [doi]
PST - ppublish
SO  - Collegian. 2012;19(4):239-46. doi: 10.1016/j.colegn.2012.02.005.


PMID- 23362605
OWN - NLM
STAT- MEDLINE
DCOM- 20130301
LR  - 20220409
IS  - 1322-7696 (Print)
IS  - 1322-7696 (Linking)
VI  - 19
IP  - 4
DP  - 2012
TI  - Effective leadership, teamwork and mentoring--essential elements in promoting
      generational cohesion in the nursing workforce and retaining nurses.
PG  - 197-202
AB  - Despite recent increases in nurse recruitment in Australia, the current nursing
      workforce is still below the predicted numbers for the future demands. The
      combination of an ageing workforce, high nursing staff turnover and an inability 
      to attract and retain nurses is eroding the capacity of the health care sector to
      appropriately respond to the care needs of the community. Currently, the nursing 
      workforce may have as many as four generations working together. Differences in
      employment needs and values, work ethics, attitudes towards authority, and
      professional aspirations, contribute to some of the cross-generational problems
      that emerge and the turnover of nursing staff. Strategies to improve the
      retention rates of nurses need to focus on building a cohesive workforce by
      utilising the strengths and skill sets that characterise different generations of
      nurses, and creating the conditions in which nurses across all generations feel
      supported and valued. The aim of this article is to explain how effective
      leadership, teamwork and mentoring can assist efforts to promote generational
      cohesion and address the decline in the number of nurses in the workforce.
FAU - Nelsey, Lorraine
AU  - Nelsey L
AD  - School of Health and Human Sciences, Southern Cross University, PO Box 157,
      Lismore, NSW 2480, Australia.
FAU - Brownie, Sonya
AU  - Brownie S
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Collegian
JT  - Collegian (Royal College of Nursing, Australia)
JID - 9612493
MH  - Australia
MH  - *Cooperative Behavior
MH  - Humans
MH  - *Intergenerational Relations
MH  - *Leadership
MH  - *Mentors
MH  - Nursing Staff/organization & administration/*supply & distribution
MH  - *Personnel Turnover
EDAT- 2013/02/01 06:00
MHDA- 2013/03/02 06:00
CRDT- 2013/02/01 06:00
PHST- 2013/02/01 06:00 [entrez]
PHST- 2013/02/01 06:00 [pubmed]
PHST- 2013/03/02 06:00 [medline]
AID - 10.1016/j.colegn.2012.03.002 [doi]
PST - ppublish
SO  - Collegian. 2012;19(4):197-202. doi: 10.1016/j.colegn.2012.03.002.


PMID- 23361278
OWN - NLM
STAT- MEDLINE
DCOM- 20130723
LR  - 20140731
IS  - 1998-4138 (Electronic)
IS  - 1998-4138 (Linking)
VI  - 8
IP  - 4
DP  - 2012 Oct-Dec
TI  - Pre-cancerous (DNA and chromosomal) lesions in professional sports.
PG  - 578-85
LID - 10.4103/0973-1482.106544 [doi]
AB  - CONTEXT: Exhaustive exercises may become detrimental, causing disturbance of
      intracellular oxidant-antioxidant balance and damage to macromolecules, leading
      to genomic instability when DNA/chromosomes get damaged. As these are
      precancerous lesions, cancer occurrence is probable. Because professional sports 
      requires high-intensity training and increasing physical demand, there may occur 
      cellular genomic instability. AIM: To evaluate genetic damage at DNA and
      chromosomal levels in hockey and baseball-soft ball players and compare with
      levels in age- and sex-matched sedentary controls. SETTING AND DESIGN: Players
      professionally active in their sport from 3 to 11 years on a daily training
      session of 4h/day were contacted during their camps, and the study was approved
      by the Institutional Ethics Committee. All participants were healthy individuals,
      not on any medication and were not taking any supplements. MATERIALS AND METHODS:
      Genetic damage using the single cell gel electrophoresis assay and buccal
      micronucleus cytome assay of 56 individuals (36 players and 20 controls) was
      evaluated. STATISTICAL ANALYSIS USED: Student's t -test, ANOVA, Pearson
      correlation and linear regression and Chi-square analysis were performed.
      RESULTS: Players had significantly elevated levels of genetic damage. There were 
      no gender differences and also no significant difference in the genetic damage
      incurred in both sports types. However, the extent of DNA migration in hockey
      players was higher. CONCLUSION: Significantly increased genomic instability in
      players of both sports was observed. Both repaired and repairable genetic damage 
      cells were observed in different tissues of the same subject. The presence of
      such genetic damage implies that these players are at an individual risk from
      cancer- and age-related diseases.
FAU - Sharma, Radhika
AU  - Sharma R
AD  - Department of Human Genetics, Guru Nanak Dev University, Amritsar, Punjab, India.
      radhivats1983@yahoo.co.in
CN  - Shailey
FAU - Gandhi, Gursatej
AU  - Gandhi G
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Cancer Res Ther
JT  - Journal of cancer research and therapeutics
JID - 101249598
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - DNA Damage
MH  - Female
MH  - Genomic Instability
MH  - Humans
MH  - Male
MH  - Micronuclei, Chromosome-Defective
MH  - Precancerous Conditions/*genetics
MH  - *Sports
MH  - Young Adult
EDAT- 2013/01/31 06:00
MHDA- 2013/07/24 06:00
CRDT- 2013/01/31 06:00
PHST- 2013/01/31 06:00 [entrez]
PHST- 2013/01/31 06:00 [pubmed]
PHST- 2013/07/24 06:00 [medline]
AID - JCanResTher_2012_8_4_578_106544 [pii]
AID - 10.4103/0973-1482.106544 [doi]
PST - ppublish
SO  - J Cancer Res Ther. 2012 Oct-Dec;8(4):578-85. doi: 10.4103/0973-1482.106544.


PMID- 23360023
OWN - NLM
STAT- MEDLINE
DCOM- 20130319
LR  - 20130130
IS  - 0019-5847 (Print)
IS  - 0019-5847 (Linking)
VI  - 110
IP  - 5
DP  - 2012 May
TI  - Point of care for gestational diabetes mellitus--a community-based study.
PG  - 314-6
AB  - Universal screening for gestational diabetes mellitus (GDM) is advocated in
      Indian women as they have the highest frequency of GDM, among South Asian
      population. For this the diagnostic procedure has to be simple, economical and
      evidence based. Hence, this study was undertaken to compare the point-of-care
      measuring capillary blood glucose (CBG) by glucometer and venous plasma glucose
      (VPG) estimated in the laboratory and to suggest the feasible diagnostic tool.
      Consecutive pregnant women in the third trimester were included in this study
      with the approval of the institutional ethical committee. They were given 75 g
      oral glucose in the fasting state. After 2 hours, CBG was measured by
      finger-prick using one touch select simple glucometer and venous blood was drawn 
      to estimate VPG in the laboratory by GOD- POD method. The diagnosis of GDM was
      based on 2 hours plasma glucose > or = 7.8 mmol/l. Among a cohort of 500 pregnant
      women, 32 (6.4%) were diagnosed as GDM in their first visit. The CBG value at 2
      hours plasma glucose > or = 7.8 mmol/l had a sensitivity of 93.8% and specificity
      of 97.4% with a false positive and false negative of 2.6% and 6.2%, respectively.
      The area under the receiver operating characteristic curve of CBG was 0.993. CBG 
      value at 2 hours plasma glucose > or = 7.8 mmol/l may be recommended for the
      diagnosis of GDM in healthcare centres where laboratory technology is not
      available.
FAU - Balaji, Vijayam
AU  - Balaji V
AD  - Dr V Seshiah Diabetes Research Institute, Chennai 600029.
FAU - Balaji, Madhuri S
AU  - Balaji MS
FAU - Paneerselvam, Arunachalam
AU  - Paneerselvam A
FAU - Thiyagarajah, Arthi
AU  - Thiyagarajah A
FAU - Seshiah, Veerasamy
AU  - Seshiah V
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - India
TA  - J Indian Med Assoc
JT  - Journal of the Indian Medical Association
JID - 7505608
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adult
MH  - Blood Glucose/*analysis
MH  - Diabetes, Gestational/*diagnosis
MH  - Female
MH  - Glucose Tolerance Test
MH  - Humans
MH  - *Point-of-Care Systems
MH  - Pregnancy
MH  - Pregnancy Trimester, Third
MH  - ROC Curve
MH  - Young Adult
EDAT- 2013/01/31 06:00
MHDA- 2013/03/21 06:00
CRDT- 2013/01/31 06:00
PHST- 2013/01/31 06:00 [entrez]
PHST- 2013/01/31 06:00 [pubmed]
PHST- 2013/03/21 06:00 [medline]
PST - ppublish
SO  - J Indian Med Assoc. 2012 May;110(5):314-6.


PMID- 23358456
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130130
LR  - 20220309
IS  - 1735-3955 (Print)
IS  - 1735-3955 (Linking)
VI  - 8
IP  - 3
DP  - 2012 Fall
TI  - Determination of normal range of bleeding time in rural and urban residents of
      Borujerd, Iran: A pilot study.
PG  - 136-42
AB  - BACKGROUND: Bleeding time test is used to assess the function of platelets in
      human body. The aim of this project was thus to estimate the sample size required
      to determine the normal range of bleeding time (BT) in Borujerd (a city in Iran).
      A pilot study was designed to determine the range of normal BT in a small group
      of normal people. The total sample size for the next study was then calculated
      according to the results. METHODS: In order to determine the sample size, a total
      of 33 volunteers participated in this study. The normal range of BT was
      determined by Ivy method. Written informed consents were obtained from all
      participants and their clinical history was recorded. The sampling was performed 
      once for each participant. However, the results were interpreted by two
      observers. The study protocol was approved by the Ethics Committee of the
      research center at Lorestan University of Medical Sciences (Iran). RESULTS: In
      this study, 33 normal participants (20 women and 13 men) were divided into four
      age groups of 35-44, 45-54, 55-64 and over 64 years old. Maximum and minimum BTs 
      in men were 209 (in the age group of 35-44 years) and 150 seconds (in the age
      group of over 64 years), respectively. On the other hand, the corresponding
      values in women were 194 (in 55-64 year-old subjects) and 145 seconds (in women
      over 64 years of age). Considering the aforementioned results, the total sample
      size for the next study was determined to be 580 normal subjects by two-sample
      t-test power analysis at a power of 0.91816. CONCLUSION: There was a significant 
      difference between the normal range of BT in participants of Borujerd and
      previously recorded range in other studies. Moreover, normal BT in men decreased 
      by aging. This study did not show any special order in increasing or decreasing
      BT in women.
FAU - Maleki, Ali
AU  - Maleki A
AD  - Assistant Professor, Department of Cardiology, School of Medicine, Lorestan
      University of Medical Sciences, Khorramabad, Iran.
FAU - Roohafza, Hamidreza
AU  - Roohafza H
FAU - Rashidi, Negin
AU  - Rashidi N
FAU - Aliyari, Farshid
AU  - Aliyari F
FAU - Ghanavati, Reza
AU  - Ghanavati R
FAU - Foroughi, Saeed
AU  - Foroughi S
FAU - Nabatchi, Behjat
AU  - Nabatchi B
FAU - Torkashvand, Maria
AU  - Torkashvand M
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - ARYA Atheroscler
JT  - ARYA atherosclerosis
JID - 101487337
PMC - PMC3557001
OTO - NOTNLM
OT  - Bleeding Time
OT  - Gender
OT  - Ivy Method
OT  - Platelet
EDAT- 2013/01/30 06:00
MHDA- 2013/01/30 06:01
CRDT- 2013/01/30 06:00
PHST- 2012/01/06 00:00 [received]
PHST- 2012/05/07 00:00 [accepted]
PHST- 2013/01/30 06:00 [entrez]
PHST- 2013/01/30 06:00 [pubmed]
PHST- 2013/01/30 06:01 [medline]
PST - ppublish
SO  - ARYA Atheroscler. 2012 Fall;8(3):136-42.


PMID- 23356097
OWN - NLM
STAT- MEDLINE
DCOM- 20130314
LR  - 20191112
IS  - 0098-8588 (Print)
IS  - 0098-8588 (Linking)
VI  - 38
IP  - 4
DP  - 2012
TI  - The ethics of postmarketing observational studies of drug safety under section
      505(o)(3) of the Food, Drug, and Cosmetic Act.
PG  - 577-606
AB  - In 2007, Congress granted the Food and Drug Administration (FDA) new powers to
      order pharmaceutical companies to conduct drug safety studies and clinical trials
      in the postmarketing period after drugs are approved The methodologies include
      observational studies that examine patients' insurance claims data and clinical
      records to infer whether drugs are safe in actual clinical practice. Such studies
      offer a valuable tool for improving drug safety, but they raise ethical and
      privacy concerns because they would entail widespread use of patients' health
      information in commercial research by drug manufacturers. This is the first
      article to explore the ethics of these section 505(0)(3) observational studies,
      so named after the section of the Food, Drug, and Cosmetic Act that authorizes
      them. Data access problems threaten to make the FDA's section 505(0)(3) study
      requirements unenforceable. Under existing federal privacy regulations, it
      appears highly unlikely that pharmaceutical companies will have reliable access
      to crucial data resources, such as insurance claims data and healthcare records, 
      to use in these studies. State privacy laws present another potential barrier to 
      data access. If pharmaceutical companies do manage to gain access to the needed
      data, this will raise serious privacy concerns because section 505(0)(3)
      observational studies do not appear to be covered by any of the major federal
      regulations that afford ethical and privacy protections to persons whose data are
      used in research. If the FDA's program of section 505(o)(3) observational studies
      fails because of the above problems, this failure will have a number of bad
      consequences: the public will be exposed to avoidable drug safety risks;
      taxpayers may be forced to bear the costs of having the FDA conduct drug safety
      investigations that would have been funded by drug manufacturers if data had been
      available; and, perhaps most troubling, the FDA may be forced to order
      postmarketing clinical trials to answer questions that could have been answered
      using observational studies. Problems with access to data for section 505(0)(3)
      studies thus could directly imperil human research subjects by forcing a needless
      over-reliance on risky postmarketing drug safety trials. This Article concludes
      by describing a promising new legal pathway for resolving these problems.
      Congress has provided the FDA a new set of powers that if skillfully exercised
      will allow the agency: (1) to facilitate pharmaceutical companies' appropriate
      access to data for use in section 505(0)(3) observational studies, (2) to impose 
      strict ethical and privacy protections for persons whose data are used in these
      studies, and (3) to mobilize private-sector funding to generate much-needed
      evidence of the safety of FDA-approved drugs.
FAU - Evans, Barbara J
AU  - Evans BJ
AD  - Health Law & Policy Institute, USA. bjevans@central.uh.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Am J Law Med
JT  - American journal of law & medicine
JID - 7509572
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Access to Information/*ethics/legislation & jurisprudence
MH  - Confidentiality/legislation & jurisprudence
MH  - Health Insurance Portability and Accountability Act
MH  - Humans
MH  - *Pharmaceutical Preparations
MH  - *Product Surveillance, Postmarketing
MH  - United States
MH  - United States Food and Drug Administration
EDAT- 2013/01/30 06:00
MHDA- 2013/03/15 06:00
CRDT- 2013/01/30 06:00
PHST- 2013/01/30 06:00 [entrez]
PHST- 2013/01/30 06:00 [pubmed]
PHST- 2013/03/15 06:00 [medline]
AID - 10.1177/009885881203800401 [doi]
PST - ppublish
SO  - Am J Law Med. 2012;38(4):577-606. doi: 10.1177/009885881203800401.


PMID- 23355766
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 0972-4567 (Print)
IS  - 0972-4567 (Linking)
VI  - 13
DP  - 2012
TI  - Current trends in negative immuno-synergy between two sexually transmitted
      infectious viruses: HIV-1 and HSV-1/2.
PG  - 51-68
AB  - In the current era of effective anti-retroviral therapy, immuno-compromised
      patients with HIV-1 infection do live long enough to suffer diseases caused by
      many opportunistic infections, such as herpes simplex virus type 1 and/or type 2 
      (HSV-1/2). An estimated two-third of the 40 million individuals that have
      contracted HIV-1 worldwide are co-infected with HSV-1/2 viruses, the causative
      agents of ocular oro-facial and genital herpes. The highest prevalence of HIV and
      HSV-1/2 infections are confined to the same regions of Sub-Saharan Africa.
      HSV-1/2 infections affect HIV-1 immunity, and vice versa. While important
      research gains have been made in understanding herpes and HIV immunity, the
      cellular and molecular mechanisms underlying the crosstalk between HSV-1/2 and
      HIV co-infection remain to be fully elucidated. Understanding the mechanisms
      behind the apparent HSV/HIV negative immuno-synergy maybe the key to successful
      HSV and HIV vaccines; both are currently unavailable. An effective herpes
      immunotherapeutic vaccine would in turn - indirectly - contribute in reducing HIV
      epidemic. The purpose of this review is: (i) to summarize the current trends in
      understanding the negative immuno-crosstalk between HIV and HSV-1/2 infections;
      and (ii) to discuss the possibility of developing a novel mucosal herpes
      immunotherapeutic strategy or even a combined or chimeric immunotherapeutic
      vaccine that simultaneously targets HIV and HSV-1/2 infections. These new trends 
      in immunology of HSV-1/2 and HIV co-infections should become part of current
      efforts in preventing sexually transmitted infections. The alternative is needed 
      to balance the ethical and financial concerns associated with the rising number
      of unsuccessful mono-valent clinical vaccine trials.
FAU - Chentoufi, Aziz Alami
AU  - Chentoufi AA
AD  - Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute,
      University of California Irvine, School of Medicine, Irvine, CA 92697-4375, USA.
FAU - Dervillez, Xavier
AU  - Dervillez X
FAU - Rubbo, Pierre-Alain
AU  - Rubbo PA
FAU - Kuo, Tiffany
AU  - Kuo T
FAU - Zhang, Xiuli
AU  - Zhang X
FAU - Nagot, Nicolas
AU  - Nagot N
FAU - Tuaillon, Edouard
AU  - Tuaillon E
FAU - Van De Perre, Philippe
AU  - Van De Perre P
FAU - Nesburn, Anthony B
AU  - Nesburn AB
FAU - Benmohamed, Lbachir
AU  - Benmohamed L
LA  - eng
GR  - R01 EY014900/EY/NEI NIH HHS/United States
GR  - R01 EY019896/EY/NEI NIH HHS/United States
GR  - R03 EY014017/EY/NEI NIH HHS/United States
PT  - Journal Article
PL  - India
TA  - Curr Trends Immunol
JT  - Current trends in immunology
JID - 101525702
PMC - PMC3552495
MID - NIHMS421159
EDAT- 2013/01/29 06:00
MHDA- 2013/01/29 06:01
CRDT- 2013/01/29 06:00
PHST- 2013/01/29 06:00 [entrez]
PHST- 2013/01/29 06:00 [pubmed]
PHST- 2013/01/29 06:01 [medline]
PST - ppublish
SO  - Curr Trends Immunol. 2012;13:51-68.


PMID- 23354644
OWN - NLM
STAT- MEDLINE
DCOM- 20131209
LR  - 20130128
IS  - 0717-6163 (Electronic)
IS  - 0034-9887 (Linking)
VI  - 140
IP  - 9
DP  - 2012 Sep
TI  - [Behaviors in public, private and university environments].
PG  - 1201-6
LID - 10.4067/S0034-98872012000900015 [doi]
LID - S0034-98872012000900015 [pii]
AB  - BACKGROUND: In contemporary democracies, rules of conduct, in public places, are 
      established by law and in private places, by morality. Between both, there is a
      middle area or interface given by community consensus. In the Community area,
      rules are consensual among its members. Institutions are an example of such
      situation. The University, as an institution, without contradicting the law,
      regulates and requires a behavior that is consistent with its purpose, beyond the
      private sphere, especially in the Schools of Medicine. We analyze what happens
      and the underlying purposes that represent the concept of University and
      Medicine. Special importance is given to ethical, social and cultural analyses.
FAU - Perez-Flores, Manuel
AU  - Perez-Flores M
AD  - Escuela de Medicina, Universidad Andres Bello, Santiago, Chile.
      mperez@clinicalascondes.cl
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Lo publico, lo privado y el espacio universitario. Reflexion bioetica.
PL  - Chile
TA  - Rev Med Chil
JT  - Revista medica de Chile
JID - 0404312
SB  - IM
MH  - *Codes of Ethics
MH  - Ethics, Institutional
MH  - Humans
MH  - Schools, Medical/*ethics
MH  - Social Control, Formal
MH  - Universities/*ethics
EDAT- 2013/01/29 06:00
MHDA- 2013/12/16 06:00
CRDT- 2013/01/29 06:00
PHST- 2012/01/27 00:00 [received]
PHST- 2012/05/23 00:00 [accepted]
PHST- 2013/01/29 06:00 [entrez]
PHST- 2013/01/29 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - S0034-98872012000900015 [pii]
AID - 10.4067/S0034-98872012000900015 [doi]
PST - ppublish
SO  - Rev Med Chil. 2012 Sep;140(9):1201-6. doi: 10.4067/S0034-98872012000900015.


PMID- 23352066
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130805
LR  - 20130128
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 14
IP  - 4
DP  - 2012 Apr 1
TI  - American Medical Association Code of Medical Ethics' opinion on cultural
      sensitivity and ethnic disparities in care.
PG  - 312-3
LID - 10.1001/virtualmentor.2012.14.4.coet1-1204 [doi]
LID - virtualmentor.2012.14.4.coet1-1204 [pii]
LA  - eng
PT  - Journal Article
DEP - 20120401
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2013/01/29 06:00
MHDA- 2013/01/29 06:01
CRDT- 2013/01/29 06:00
PHST- 2013/01/29 06:00 [entrez]
PHST- 2013/01/29 06:00 [pubmed]
PHST- 2013/01/29 06:01 [medline]
AID - virtualmentor.2012.14.4.coet1-1204 [pii]
AID - 10.1001/virtualmentor.2012.14.4.coet1-1204 [doi]
PST - epublish
SO  - Virtual Mentor. 2012 Apr 1;14(4):312-3. doi:
      10.1001/virtualmentor.2012.14.4.coet1-1204.


PMID- 23352015
OWN - NLM
STAT- MEDLINE
DCOM- 20130823
LR  - 20130128
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 14
IP  - 3
DP  - 2012 Mar 1
TI  - The ethics of organ transplantation: a brief history.
PG  - 264-8
LID - 10.1001/virtualmentor.2012.14.3.mhst1-1203 [doi]
LID - virtualmentor.2012.14.3.mhst1-1203 [pii]
FAU - Jonsen, Albert R
AU  - Jonsen AR
AD  - University of San Francisco, Fromm Institute for Lifelong Learning, San
      Francisco, CA, USA.
LA  - eng
PT  - Historical Article
PT  - Journal Article
DEP - 20120301
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
SB  - IM
MH  - Heart Transplantation/ethics/history
MH  - History, 20th Century
MH  - Humans
MH  - Kidney Transplantation/ethics/history
MH  - Organ Transplantation/*ethics/history
MH  - South Africa
MH  - Tissue and Organ Procurement/ethics/history/statistics & numerical data
MH  - United States
EDAT- 2013/01/29 06:00
MHDA- 2013/08/24 06:00
CRDT- 2013/01/29 06:00
PHST- 2013/01/29 06:00 [entrez]
PHST- 2013/01/29 06:00 [pubmed]
PHST- 2013/08/24 06:00 [medline]
AID - virtualmentor.2012.14.3.mhst1-1203 [pii]
AID - 10.1001/virtualmentor.2012.14.3.mhst1-1203 [doi]
PST - epublish
SO  - Virtual Mentor. 2012 Mar 1;14(3):264-8. doi:
      10.1001/virtualmentor.2012.14.3.mhst1-1203.


PMID- 23352010
OWN - NLM
STAT- MEDLINE
DCOM- 20130823
LR  - 20130128
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 14
IP  - 3
DP  - 2012 Mar 1
TI  - Reproductive tissue transplants defy legal and ethical categorization.
PG  - 232-6
LID - 10.1001/virtualmentor.2012.14.3.hlaw1-1203 [doi]
LID - virtualmentor.2012.14.3.hlaw1-1203 [pii]
FAU - Blake, Valarie
AU  - Blake V
AD  - American Medical Association, Chicago, IL, USA.
FAU - Shah, Kavita
AU  - Shah K
LA  - eng
PT  - Journal Article
DEP - 20120301
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
SB  - IM
MH  - Animals
MH  - Female
MH  - Humans
MH  - Informed Consent/ethics/legislation & jurisprudence
MH  - Male
MH  - Organ Transplantation/ethics/*legislation & jurisprudence
MH  - Ovary/*transplantation
MH  - Reproductive Techniques, Assisted/ethics/legislation & jurisprudence
MH  - Testis/*transplantation
MH  - United States
EDAT- 2013/01/29 06:00
MHDA- 2013/08/24 06:00
CRDT- 2013/01/29 06:00
PHST- 2013/01/29 06:00 [entrez]
PHST- 2013/01/29 06:00 [pubmed]
PHST- 2013/08/24 06:00 [medline]
AID - virtualmentor.2012.14.3.hlaw1-1203 [pii]
AID - 10.1001/virtualmentor.2012.14.3.hlaw1-1203 [doi]
PST - epublish
SO  - Virtual Mentor. 2012 Mar 1;14(3):232-6. doi:
      10.1001/virtualmentor.2012.14.3.hlaw1-1203.


PMID- 23352005
OWN - NLM
STAT- MEDLINE
DCOM- 20130823
LR  - 20130128
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 14
IP  - 3
DP  - 2012 Mar 1
TI  - Online ethics-education modules and ethics forums of the American Society of
      Transplant Surgeons.
PG  - 201-3
LID - 10.1001/virtualmentor.2012.14.3.medu1-1203 [doi]
LID - virtualmentor.2012.14.3.medu1-1203 [pii]
FAU - Ham, John M
AU  - Ham JM
AD  - University of Nevada School of Medicine, Las Vegas, NV, USA.
LA  - eng
PT  - Journal Article
DEP - 20120301
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
SB  - IM
MH  - *Computer-Assisted Instruction
MH  - Congresses as Topic/organization & administration
MH  - Ethics, Medical/*education
MH  - Humans
MH  - Organ Transplantation/education/*ethics
MH  - Societies, Medical/ethics/organization & administration
MH  - United States
EDAT- 2013/01/29 06:00
MHDA- 2013/08/24 06:00
CRDT- 2013/01/29 06:00
PHST- 2013/01/29 06:00 [entrez]
PHST- 2013/01/29 06:00 [pubmed]
PHST- 2013/08/24 06:00 [medline]
AID - virtualmentor.2012.14.3.medu1-1203 [pii]
AID - 10.1001/virtualmentor.2012.14.3.medu1-1203 [doi]
PST - epublish
SO  - Virtual Mentor. 2012 Mar 1;14(3):201-3. doi:
      10.1001/virtualmentor.2012.14.3.medu1-1203.


PMID- 23351952
OWN - NLM
STAT- MEDLINE
DCOM- 20130805
LR  - 20130128
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 14
IP  - 12
DP  - 2012 Dec 1
TI  - The National Resident Matching Program all-in policy: potential consequences and 
      ethical questions.
PG  - 1008-10
LID - 10.1001/virtualmentor.2012.14.12.pfor1-1212 [doi]
LID - virtualmentor.2012.14.12.pfor1-1212 [pii]
FAU - Saultz, Jennifer
AU  - Saultz J
AD  - The Ohio State University Department of Internal Medicine, Columbus, OH, USA.
FAU - Wright, Nathan
AU  - Wright N
LA  - eng
PT  - Journal Article
DEP - 20121201
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
SB  - IM
MH  - Attitude of Health Personnel
MH  - *Career Choice
MH  - Education, Medical, Graduate/*ethics
MH  - Humans
MH  - Internship and Residency/*ethics
MH  - *Medicine
MH  - Motivation
MH  - Osteopathic Physicians/education
MH  - *School Admission Criteria
MH  - Selection Bias
MH  - United States
EDAT- 2013/01/29 06:00
MHDA- 2013/08/06 06:00
CRDT- 2013/01/29 06:00
PHST- 2013/01/29 06:00 [entrez]
PHST- 2013/01/29 06:00 [pubmed]
PHST- 2013/08/06 06:00 [medline]
AID - virtualmentor.2012.14.12.pfor1-1212 [pii]
AID - 10.1001/virtualmentor.2012.14.12.pfor1-1212 [doi]
PST - epublish
SO  - Virtual Mentor. 2012 Dec 1;14(12):1008-10. doi:
      10.1001/virtualmentor.2012.14.12.pfor1-1212.


PMID- 23351899
OWN - NLM
STAT- MEDLINE
DCOM- 20130820
LR  - 20130128
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 14
IP  - 11
DP  - 2012 Nov 1
TI  - Cancer gene sequencing: ethical challenges and promises.
PG  - 868-72
LID - 10.1001/virtualmentor.2012.14.11.stas1-1211 [doi]
LID - virtualmentor.2012.14.11.stas1-1211 [pii]
FAU - Devarakonda, Siddhartha
AU  - Devarakonda S
AD  - Saint Luke's Hospital, Chesterfield, Missouri, USA.
FAU - Govindan, Ramaswamy
AU  - Govindan R
FAU - Hammerman, Peter S
AU  - Hammerman PS
LA  - eng
PT  - Journal Article
DEP - 20121101
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
SB  - IM
MH  - Biomedical Research/ethics
MH  - Forecasting
MH  - Genetic Testing/economics/*ethics/methods
MH  - High-Throughput Nucleotide Sequencing/economics/ethics/methods
MH  - Humans
MH  - Neoplasms/diagnosis/*genetics
MH  - Sequence Analysis, DNA/economics/ethics/methods
EDAT- 2013/01/29 06:00
MHDA- 2013/08/21 06:00
CRDT- 2013/01/29 06:00
PHST- 2013/01/29 06:00 [entrez]
PHST- 2013/01/29 06:00 [pubmed]
PHST- 2013/08/21 06:00 [medline]
AID - virtualmentor.2012.14.11.stas1-1211 [pii]
AID - 10.1001/virtualmentor.2012.14.11.stas1-1211 [doi]
PST - epublish
SO  - Virtual Mentor. 2012 Nov 1;14(11):868-72. doi:
      10.1001/virtualmentor.2012.14.11.stas1-1211.


PMID- 23351860
OWN - NLM
STAT- MEDLINE
DCOM- 20130822
LR  - 20130919
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 14
IP  - 10
DP  - 2012 Oct 1
TI  - Ethical issues in pediatric emergency medicine's preparation for and response to 
      disasters.
PG  - 801-4
LID - 10.1001/virtualmentor.2012.14.10.pfor2-1210 [doi]
LID - virtualmentor.2012.14.10.pfor2-1210 [pii]
FAU - Antommaria, Armand H Matheny
AU  - Antommaria AH
AD  - Child Health Ethics Center at Cincinnati Children's Hospital Medical Center in
      Ohio, USA.
FAU - Kaziny, Brent D
AU  - Kaziny BD
LA  - eng
PT  - Journal Article
DEP - 20121001
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Algorithms
MH  - Child
MH  - Child, Preschool
MH  - Disaster Planning
MH  - *Disasters
MH  - Emergency Medical Services/*ethics
MH  - *Ethics, Medical
MH  - Humans
MH  - Infant
MH  - Injury Severity Score
MH  - Pediatrics/*ethics
MH  - Resource Allocation/ethics
MH  - Triage/ethics
MH  - United States
MH  - Young Adult
EDAT- 2013/01/29 06:00
MHDA- 2013/08/24 06:00
CRDT- 2013/01/29 06:00
PHST- 2013/01/29 06:00 [entrez]
PHST- 2013/01/29 06:00 [pubmed]
PHST- 2013/08/24 06:00 [medline]
AID - virtualmentor.2012.14.10.pfor2-1210 [pii]
AID - 10.1001/virtualmentor.2012.14.10.pfor2-1210 [doi]
PST - epublish
SO  - Virtual Mentor. 2012 Oct 1;14(10):801-4. doi:
      10.1001/virtualmentor.2012.14.10.pfor2-1210.


PMID- 23351859
OWN - NLM
STAT- MEDLINE
DCOM- 20130822
LR  - 20151119
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 14
IP  - 10
DP  - 2012 Oct 1
TI  - Legal and ethical policies regarding research involving critically ill children.
PG  - 797-800
LID - 10.1001/virtualmentor.2012.14.10.pfor1-1210 [doi]
LID - virtualmentor.2012.14.10.pfor1-1210 [pii]
FAU - Koogler, Tracy
AU  - Koogler T
AD  - MacLean Center for Clinical Ethics, University of Chicago, USA.
LA  - eng
PT  - Journal Article
DEP - 20121001
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
SB  - IM
MH  - Child
MH  - Critical Care/*ethics/*legislation & jurisprudence
MH  - Critical Illness/*therapy
MH  - Decision Making
MH  - Emergency Medical Services/*ethics/*legislation & jurisprudence
MH  - *Ethics, Medical
MH  - Human Experimentation/*ethics/*legislation & jurisprudence
MH  - Humans
MH  - Informed Consent By Minors/legislation & jurisprudence
MH  - Parental Consent/legislation & jurisprudence
MH  - Patient Selection/*ethics
MH  - Risk Assessment/ethics/legislation & jurisprudence
MH  - Treatment Outcome
MH  - United States
EDAT- 2013/01/29 06:00
MHDA- 2013/08/24 06:00
CRDT- 2013/01/29 06:00
PHST- 2013/01/29 06:00 [entrez]
PHST- 2013/01/29 06:00 [pubmed]
PHST- 2013/08/24 06:00 [medline]
AID - virtualmentor.2012.14.10.pfor1-1210 [pii]
AID - 10.1001/virtualmentor.2012.14.10.pfor1-1210 [doi]
PST - epublish
SO  - Virtual Mentor. 2012 Oct 1;14(10):797-800. doi:
      10.1001/virtualmentor.2012.14.10.pfor1-1210.


PMID- 23351855
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130822
LR  - 20130919
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 14
IP  - 10
DP  - 2012 Oct 1
TI  - The AMA code of medical ethics' opinion on confidential services for children and
      adolescents.
PG  - 778-9
LID - 10.1001/virtualmentor.2012.14.10.coet1-1210 [doi]
LID - virtualmentor.2012.14.10.coet1-1210 [pii]
LA  - eng
PT  - Journal Article
DEP - 20121001
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2013/01/29 06:00
MHDA- 2013/01/29 06:01
CRDT- 2013/01/29 06:00
PHST- 2013/01/29 06:00 [entrez]
PHST- 2013/01/29 06:00 [pubmed]
PHST- 2013/01/29 06:01 [medline]
AID - virtualmentor.2012.14.10.coet1-1210 [pii]
AID - 10.1001/virtualmentor.2012.14.10.coet1-1210 [doi]
PST - epublish
SO  - Virtual Mentor. 2012 Oct 1;14(10):778-9. doi:
      10.1001/virtualmentor.2012.14.10.coet1-1210.


PMID- 23351854
OWN - NLM
STAT- MEDLINE
DCOM- 20130822
LR  - 20130919
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 14
IP  - 10
DP  - 2012 Oct 1
TI  - Teaching trainees to perform procedures on critically ill children: ethical
      concerns and emerging solutions.
PG  - 771-7
LID - 10.1001/virtualmentor.2012.14.10.medu1-1210 [doi]
LID - virtualmentor.2012.14.10.medu1-1210 [pii]
FAU - Wolbrink, Traci A
AU  - Wolbrink TA
AD  - Boston Children's Hospital, USA.
FAU - Burns, Jeffrey P
AU  - Burns JP
LA  - eng
PT  - Journal Article
DEP - 20121001
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
SB  - IM
MH  - Child
MH  - Clinical Competence/*standards
MH  - Computer Simulation
MH  - Critical Illness/*therapy
MH  - Curriculum
MH  - Education, Medical, Graduate/*ethics
MH  - Emergency Medical Services/*ethics
MH  - Hospitals, Pediatric
MH  - Humans
MH  - Intensive Care Units, Pediatric
MH  - Internship and Residency/*ethics
MH  - Manikins
MH  - Pediatrics/*education/*ethics
MH  - United States
EDAT- 2013/01/29 06:00
MHDA- 2013/08/24 06:00
CRDT- 2013/01/29 06:00
PHST- 2013/01/29 06:00 [entrez]
PHST- 2013/01/29 06:00 [pubmed]
PHST- 2013/08/24 06:00 [medline]
AID - virtualmentor.2012.14.10.medu1-1210 [pii]
AID - 10.1001/virtualmentor.2012.14.10.medu1-1210 [doi]
PST - epublish
SO  - Virtual Mentor. 2012 Oct 1;14(10):771-7. doi:
      10.1001/virtualmentor.2012.14.10.medu1-1210.


PMID- 23351564
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130131
LR  - 20211021
IS  - 1560-8115 (Print)
IS  - 1560-8115 (Linking)
VI  - 20
IP  - 1
DP  - 2012 Dec 6
TI  - Assessing the effectiveness and cost-effectiveness of audit and feedback on
      physician's prescribing indicators: study protocol of a randomized controlled
      trial with economic evaluation.
PG  - 88
LID - 10.1186/2008-2231-20-88 [doi]
AB  - UNLABELLED: BACKGROUND: Physician prescribing is the most frequent medical
      intervention with a highest impact on healthcare costs and outcomes. Therefore
      improving and promoting rational drug use is a great interest. We aimed to assess
      the effectiveness and cost-effectiveness of two forms of conducting prescribing
      audit and feedback interventions and a printed educational material intervention 
      in improving physician prescribing. METHOD/DESIGN: A four-arm randomized trial
      with economic evaluation will be conducted in Tehran. Three interventions
      (routine feedback, revised feedback, and printed educational material) and a no
      intervention control arm will be compared. Physicians working in outpatient
      practices are randomly allocated to one of the four arms using stratified
      randomized sampling. The interventions are developed based on a review of
      literature, physician interviews, current experiences in Iran and with
      theoretical insights from the Theory of Planned Behavior. Effects of the
      interventions on improving antibiotics and corticosteroids prescribing will be
      assessed in regression analyses. Cost data will be assessed from a health care
      provider's perspective and incremental cost-effectiveness ratios will be
      calculated. DISCUSSION: This study will determine the effectiveness and
      cost-effectiveness of three interventions and allow us to determine the most
      effective interventions in improving prescribing pattern. If the interventions
      are cost-effective, they will likely be applied nationwide. TRIAL REGISTRATION:
      Iranian Registry of Clinical Trials Registration Number:
      IRCT201106086740N1Pharmaceutical Sciences Research Center of TUMS Ethics
      Committee Registration Number: 90-02-27-07.
FAU - Soleymani, Fatemeh
AU  - Soleymani F
AD  - Department of Pharmacoeconomics and Pharmaceutical Management, Faculty of
      Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
      arashidian@tums.ac.ir.
FAU - Rashidian, Arash
AU  - Rashidian A
FAU - Dinarvand, Rassoul
AU  - Dinarvand R
FAU - Kebriaeezade, Abbas
AU  - Kebriaeezade A
FAU - Hosseini, Mostafa
AU  - Hosseini M
FAU - Abdollahi, Mohammad
AU  - Abdollahi M
LA  - eng
PT  - Journal Article
DEP - 20121206
PL  - Switzerland
TA  - Daru
JT  - Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences
JID - 101125969
PMC - PMC3557192
EDAT- 2013/01/29 06:00
MHDA- 2013/01/29 06:01
CRDT- 2013/01/29 06:00
PHST- 2012/10/30 00:00 [received]
PHST- 2012/11/30 00:00 [accepted]
PHST- 2013/01/29 06:00 [entrez]
PHST- 2013/01/29 06:00 [pubmed]
PHST- 2013/01/29 06:01 [medline]
AID - 2008-2231-20-88 [pii]
AID - 10.1186/2008-2231-20-88 [doi]
PST - epublish
SO  - Daru. 2012 Dec 6;20(1):88. doi: 10.1186/2008-2231-20-88.


PMID- 23351537
OWN - NLM
STAT- MEDLINE
DCOM- 20130805
LR  - 20220317
IS  - 1932-2275 (Print)
IS  - 1932-2275 (Linking)
VI  - 31
IP  - 1
DP  - 2013 Mar
TI  - Anesthesia in an austere setting: lessons learned from the haiti relief
      operation.
PG  - 107-15
LID - 10.1016/j.anclin.2012.10.003 [doi]
LID - S1932-2275(12)00139-5 [pii]
AB  - The practice of medicine to care for injured patients after an earthquake can
      challenge physicians. The great need requires an open mind to develop anesthetic 
      plans around locally available resources. A focus on monitored anesthetic care
      and regional anesthesia is frequently practiced and beneficial to patients.
      Anesthesiologists will serve as leaders to organize perioperative surgical
      services and provide input into the ethical triage of patients. The physicians
      should be mentally and physically prepared to enter into service in this
      disorganized zone of service to provide care.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Morey, Timothy E
AU  - Morey TE
AD  - Department of Anesthesiology, University of Florida, Gainesville, FL 32610, USA. 
      morey@ufl.edu
FAU - Rice, Mark J
AU  - Rice MJ
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121117
PL  - United States
TA  - Anesthesiol Clin
JT  - Anesthesiology clinics
JID - 101273663
SB  - IM
MH  - Anesthesia/*methods
MH  - *Earthquakes
MH  - Haiti
MH  - Humans
MH  - *Relief Work
MH  - Triage/ethics
EDAT- 2013/01/29 06:00
MHDA- 2013/08/06 06:00
CRDT- 2013/01/29 06:00
PHST- 2013/01/29 06:00 [entrez]
PHST- 2013/01/29 06:00 [pubmed]
PHST- 2013/08/06 06:00 [medline]
AID - S1932-2275(12)00139-5 [pii]
AID - 10.1016/j.anclin.2012.10.003 [doi]
PST - ppublish
SO  - Anesthesiol Clin. 2013 Mar;31(1):107-15. doi: 10.1016/j.anclin.2012.10.003. Epub 
      2012 Nov 17.


PMID- 23351260
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130820
LR  - 20130128
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 14
IP  - 6
DP  - 2012 Jun 1
TI  - The ethics of genetic testing in psychiatry.
PG  - 460-3
LID - 10.1001/virtualmentor.2012.14.6.jdsc1-1206 [doi]
LID - virtualmentor.2012.14.6.jdsc1-1206 [pii]
FAU - Besterman, Aaron D
AU  - Besterman AD
AD  - University of California, San Francisco, USA.
LA  - eng
PT  - Comment
PT  - Journal Article
DEP - 20120601
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
CON - Harv Rev Psychiatry. 2008;16(6):322-38. PMID: 19085387
EDAT- 2013/01/29 06:00
MHDA- 2013/01/29 06:01
CRDT- 2013/01/29 06:00
PHST- 2013/01/29 06:00 [entrez]
PHST- 2013/01/29 06:00 [pubmed]
PHST- 2013/01/29 06:01 [medline]
AID - virtualmentor.2012.14.6.jdsc1-1206 [pii]
AID - 10.1001/virtualmentor.2012.14.6.jdsc1-1206 [doi]
PST - epublish
SO  - Virtual Mentor. 2012 Jun 1;14(6):460-3. doi:
      10.1001/virtualmentor.2012.14.6.jdsc1-1206.


PMID- 23351205
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130815
LR  - 20130128
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 14
IP  - 5
DP  - 2012 May 1
TI  - The AMA Code of Medical Ethics' opinion on physicians treating family members.
PG  - 396-7
LID - 10.1001/virtualmentor.2012.14.5.coet1-1205 [doi]
LID - virtualmentor.2012.14.5.coet1-1205 [pii]
LA  - eng
PT  - Journal Article
DEP - 20120501
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
EDAT- 2013/01/29 06:00
MHDA- 2013/01/29 06:01
CRDT- 2013/01/29 06:00
PHST- 2013/01/29 06:00 [entrez]
PHST- 2013/01/29 06:00 [pubmed]
PHST- 2013/01/29 06:01 [medline]
AID - virtualmentor.2012.14.5.coet1-1205 [pii]
AID - 10.1001/virtualmentor.2012.14.5.coet1-1205 [doi]
PST - epublish
SO  - Virtual Mentor. 2012 May 1;14(5):396-7. doi:
      10.1001/virtualmentor.2012.14.5.coet1-1205.


PMID- 23348654
OWN - NLM
STAT- MEDLINE
DCOM- 20140106
LR  - 20191112
IS  - 1809-4546 (Electronic)
IS  - 0100-6991 (Linking)
VI  - 39
IP  - 6
DP  - 2012 Dec
TI  - [Assessment of preceptorship in general surgery residency in the operating room, 
      comparison between a teaching hospital and a non teaching hospital].
PG  - 547-52
LID - S0100-69912012000600017 [pii]
AB  - BACKGROUND: Medical residency is well known as the best training method after
      graduation. It is a moment when, in addition to receiving technical guidance,
      residents should also develop attitudes, ethics, and professionalism. In order
      for that to occur, preceptors should be prepared for their task. OBJECTIVE: To
      evaluate and compare the preceptorship in the Medical Residency in General
      Surgery program, in the operating room of a Teaching Hospital (TH) and a
      Non-teaching Hospital (NTH), from the viewpoint of the residents who entered in
      2010 and 2011. METHODS: A questionnaire was applied to the residents, adapted
      from Sarker, Vincent and Darzi, and the Likert scale was used to qualify the
      survey items on the preceptors' attitudes. RESULTS: At the TH, 12 preceptors were
      evaluated by 7 residents. One of the residents did not answer the questionnaire. 
      At the NTH, 11 preceptors were evaluated by 13 residents. The comparison of the
      distribution of responses between hospitals was analyzed using the chi-squared
      test for trend. Significance level was set at 5%. The statistical analysis was
      processed by the statistical software SAS(R) System version 6.11 (SAS Institute, 
      Inc., Cary, North Carolina). The NTH showed a greater trend for discordant and
      indifferent responses than the TH. Only one question resulted in statistical
      significance between the hospitals. No significant difference was found between
      hospitals in the comparison of the responses to the remaining CONCLUSION: Only
      question 4 ("Keeps focused on the operation") showed a significant difference
      (p=0.010) in the distribution of responses. The two hospitals exhibited similar
      preceptorship quality.
FAU - Santos, Elizabeth Gomes dos
AU  - Santos EG
AD  - Hospital Universitario Clementino Fraga Filho and Hospital Municipal Salgado
      Filho. eligsant54@gmail.com
FAU - Ferreira, Rafael Rodriguez
AU  - Ferreira RR
FAU - Mannarino, Vera Lucia
AU  - Mannarino VL
FAU - Leher, Elizabeth Menezes Teixeira
AU  - Leher EM
FAU - Goldwasser, Rosane S
AU  - Goldwasser RS
FAU - Bravo Neto, Guilherme Pinto
AU  - Bravo Neto GP
LA  - por
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
TT  - Avaliacao da preceptoria na residencia medica em cirurgia geral, no centro
      cirurgico, comparacao entre um hospital universitario e um hospital nao
      universitario.
PL  - Brazil
TA  - Rev Col Bras Cir
JT  - Revista do Colegio Brasileiro de Cirurgioes
JID - 7809515
SB  - IM
MH  - Brazil
MH  - General Surgery/*education
MH  - *Hospitals, Teaching
MH  - *Internship and Residency
MH  - Operating Rooms
MH  - *Preceptorship
EDAT- 2013/01/26 06:00
MHDA- 2014/01/07 06:00
CRDT- 2013/01/26 06:00
PHST- 2013/01/26 06:00 [entrez]
PHST- 2013/01/26 06:00 [pubmed]
PHST- 2014/01/07 06:00 [medline]
AID - S0100-69912012000600017 [pii]
AID - 10.1590/s0100-69912012000600017 [doi]
PST - ppublish
SO  - Rev Col Bras Cir. 2012 Dec;39(6):547-52. doi: 10.1590/s0100-69912012000600017.


PMID- 23346523
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130314
LR  - 20211021
IS  - 2233-8233 (Print)
IS  - 2093-8896 (Linking)
VI  - 39
IP  - 4
DP  - 2012 Dec
TI  - Current issues on a standard for surrogate pregnancy procedures.
PG  - 138-43
LID - 10.5653/cerm.2012.39.4.138 [doi]
AB  - While Korea does not have any legal statement on surrogacy, treatments are
      carried out in practice. As a result, every Institutional Review Board (IRB) of
      each fertility clinic faces an ethical predicament in reviewing each case. There 
      is a need to arrange the institutions' own standards of surrogate pregnancy
      procedures before the establishment of national or professional regulation. This 
      article examines the legal, social, and medical issues of surrogacy to help IRBs 
      to judge their cases.
FAU - Ha, Jung-Ok
AU  - Ha JO
AD  - Institute for Gender Research, Seoul National University Social Science College, 
      Seoul, Korea.
LA  - eng
PT  - Journal Article
DEP - 20121231
PL  - Korea (South)
TA  - Clin Exp Reprod Med
JT  - Clinical and experimental reproductive medicine
JID - 101563916
PMC - PMC3548071
OTO - NOTNLM
OT  - Institutional Review Board
OT  - Standard for surrogate pregnancy procedures
OT  - Surrogacy
EDAT- 2013/01/25 06:00
MHDA- 2013/01/25 06:01
CRDT- 2013/01/25 06:00
PHST- 2012/09/03 00:00 [received]
PHST- 2012/09/13 00:00 [revised]
PHST- 2012/09/14 00:00 [accepted]
PHST- 2013/01/25 06:00 [entrez]
PHST- 2013/01/25 06:00 [pubmed]
PHST- 2013/01/25 06:01 [medline]
AID - 10.5653/cerm.2012.39.4.138 [doi]
PST - ppublish
SO  - Clin Exp Reprod Med. 2012 Dec;39(4):138-43. doi: 10.5653/cerm.2012.39.4.138. Epub
      2012 Dec 31.


PMID- 23346226
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130314
LR  - 20211021
IS  - 1752-4571 (Print)
IS  - 1752-4571 (Linking)
VI  - 5
IP  - 8
DP  - 2012 Dec
TI  - Conservation genetics and evolution in an endangered species: research in Sonoran
      topminnows.
PG  - 806-19
LID - 10.1111/j.1752-4571.2012.00259.x [doi]
AB  - Conservation genetics of endangered species has primarily focused on using
      neutral markers to determine units of conservation and estimating evolutionary
      parameters. Because the endangered Sonoran topminnow can be bred in the
      laboratory and has a relatively short generation length, experiments to examine
      both detrimental and adaptive variations are also possible. Here, we discuss over
      two decades of empirical and experimental observations in the Sonoran topminnow. 
      Results from this research have been used to determine species and evolutionary
      significant units using neutral markers, document inbreeding and outbreeding
      depression and genetic load using experimental crosses, and measure adaptive
      differences in fitness-related traits and variation in pathogen resistance among 
      populations and major histocompatibility complex genotypes. In addition, both
      premating and postmating reproductive isolation between Gila and Yaqui topminnows
      have been experimentally determined, and the predicted and observed ancestry of
      these two species in experimental crosses has been examined over time. Although
      some have suggested that endangered species are unsuitable for experimentation
      because of both practical and ethical considerations, these results demonstrate
      that in this case an endangered species can be employed to examine fundamental
      questions in conservation and evolution.
FAU - Hedrick, Philip W
AU  - Hedrick PW
AD  - School of Life Sciences, Arizona State University Tempe, AZ, USA.
FAU - Hurt, Carla R
AU  - Hurt CR
LA  - eng
PT  - Journal Article
PL  - England
TA  - Evol Appl
JT  - Evolutionary applications
JID - 101461828
PMC - PMC3552399
OTO - NOTNLM
OT  - evolutionary significant units
OT  - inbreeding depression
OT  - major histocompatibility complex
OT  - mtDNA
OT  - outbreeding depression
OT  - reproductive isolation
EDAT- 2013/01/25 06:00
MHDA- 2013/01/25 06:01
CRDT- 2013/01/25 06:00
PHST- 2012/02/17 00:00 [received]
PHST- 2012/02/23 00:00 [accepted]
PHST- 2013/01/25 06:00 [entrez]
PHST- 2013/01/25 06:00 [pubmed]
PHST- 2013/01/25 06:01 [medline]
AID - 10.1111/j.1752-4571.2012.00259.x [doi]
PST - ppublish
SO  - Evol Appl. 2012 Dec;5(8):806-19. doi: 10.1111/j.1752-4571.2012.00259.x.


PMID- 23343586
OWN - NLM
STAT- MEDLINE
DCOM- 20140228
LR  - 20181202
IS  - 1661-4127 (Electronic)
IS  - 1661-4119 (Linking)
VI  - 19
IP  - 6
DP  - 2012
TI  - Ethical implications of the increasing use of complementary and alternative
      medicine.
PG  - 311-8
LID - 10.1159/000346001 [doi]
AB  - BACKGROUND: The increasing demand for complementary and alternative medicine
      (CAM) raises ethical questions about specific aspects of both CAM and
      conventional medicine (COM). METHODS: The present article provides a critical
      survey of the most important ethical aspects in the current debate about CAM.
      RESULTS: The relevant ethical issues arise mainly in 4 main areas: 1) patient
      information, 2) research ethics, 3) cost, and 4) education. Most of the
      contributions used for our purpose are based upon the implicit assumption that,
      in principle, the ethics of CAM and COM have to be identical because of the same 
      underlying doctor-patient relationship. This premise is shared by the author.
      CONCLUSIONS: Substantial efforts on various levels will have to be made in order 
      to create the conditions necessary for CAM to be ethically justified. But the
      ethical implications for COM also have to be considered.
CI  - Copyright (c) 2012 S. Karger AG, Basel.
FAU - Teichfischer, Philipp
AU  - Teichfischer P
AD  - Fachbereich Geschichte, Ethik und Theorie der Medizin, Medizinische Fakultat der 
      Otto-von-Guericke-Universitat Magdeburg, Germany.
      philipp.teichfischer@med.ovgu.de
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121214
PL  - Switzerland
TA  - Forsch Komplementmed
JT  - Forschende Komplementarmedizin (2006)
JID - 101269884
SB  - IM
MH  - Beneficence
MH  - Clinical Competence
MH  - Complementary Therapies/economics/*ethics/*statistics & numerical data
MH  - Cost-Benefit Analysis/economics
MH  - Drug Approval
MH  - Education, Medical
MH  - *Ethics, Medical
MH  - Germany
MH  - Homeopathy/economics/ethics
MH  - Humans
MH  - National Health Programs/economics/ethics
MH  - Patient Education as Topic/economics/ethics
MH  - Physician-Patient Relations/ethics
MH  - Phytotherapy/economics/ethics
MH  - Treatment Outcome
EDAT- 2013/01/25 06:00
MHDA- 2014/03/01 06:00
CRDT- 2013/01/25 06:00
PHST- 2013/01/25 06:00 [entrez]
PHST- 2013/01/25 06:00 [pubmed]
PHST- 2014/03/01 06:00 [medline]
AID - 000346001 [pii]
AID - 10.1159/000346001 [doi]
PST - ppublish
SO  - Forsch Komplementmed. 2012;19(6):311-8. doi: 10.1159/000346001. Epub 2012 Dec 14.


PMID- 23342896
OWN - NLM
STAT- MEDLINE
DCOM- 20130301
LR  - 20170303
IS  - 0017-0011 (Print)
IS  - 0017-0011 (Linking)
VI  - 83
IP  - 9
DP  - 2012 Sep
TI  - [State of nutrition and diet habits versus estradiol level and its changes in the
      pre-season preparatory period for the league contest match in female handball and
      basketball players].
PG  - 674-80
AB  - BACKGROUND: Intense exercise is known to induce menstrual disturbances--irregular
      menstrual cycles, oligomenorrhea and amenorrhea in female athletes. Menstrual
      disturbances, followed by hypoestrogenism, are associated with infertility
      decreased bone mineral density high prevalence of stress fractures, and
      endothelial dysfunction. OBJECTIVES: The aim of the study was to assess the
      effect of nutrition and diet habits on the estradiol level and its changes in the
      pre-season preparatory period for the league contest match in female handball and
      basketball players. MATERIALS AND METHODS: Fifty healthy young female handball
      and basketball players were enrolled into the study before the opening of the
      season, after a 2-month holiday period, without regular physical activity and
      diet restrictions. Serum estradiol was determined at the beginning and after 3
      months of moderate aerobic training. Each woman was studied between the 3rd and
      5th day of her menstrual cycle. In all subjects, medical history was obtained,
      together with the anthropometric measurements (body mass and height). The body
      mass index was calculated according to the standard formula. The use of hormonal 
      contraception in the last 3 months, low-caloric diet in the last 6 months, body
      mass changes of more than 3 kilograms in the last 6 months, secondary amenorrhea 
      and stress fractures in medical history constituted the exclusion criteria.
      Informed consent was obtained from each participant and the study protocol was
      approved by the Ethics Committee of the Medical University of Silesia. Venous
      blood samples (2 ml) for estradiol levels measurements were taken twice: at the
      beginning of the preparatory period and after three months of moderate aerobic
      exercise training (20 hours per week). Blood samples were collected according to 
      the kit manufacturer's recommendations. Serum and plasma samples were stored
      frozen at -80 degrees C. Serum estradiol was determined by enzyme-linked
      immunosorbent assay (ELISA) (DRG Instruments GmbH, Marburg, Germany) with a lower
      limit of sensitivity of 9.714 pg/mL; the intra- and inter-assay coefficients of
      variation were 4.7% and 7.8%. All statistical analyses were performed with the
      use of Statistica 8.0 software. The results are presented as means +/- SD. The
      Wilcoxon rank test was used to compare the before and after exercise
      measurements. The Mann-Whitney U test was used for subgroups comparisons. The
      results were considered statistically significant when the p value was less than 
      0.05. RESULTS: After a 2-month holiday period, without regular physical exercise,
      p < 0.01) serum estradiol level was significantly lower in the basketball than
      handball players (48.7 +/- 19.6 vs. 62.3 +/- 18.9 pg/ml, p < 0.01). Although, no 
      body mass changes were noticed (delta = - 0.3 +/- 0.3 kg), after 3 months of
      moderate aerobic training estradiol level was significantly decreased in the
      whole study population (58.0 +/- 20.0 vs. 41.4 +/- 18.9 pg/ml, p < 0.001).
      CONCLUSIONS: Diet habits and nutrition did not correlate with estradiol plasma
      levels in female handball and basketball players after a 2-month holiday period. 
      Regular exercises correlate with the decrease of serum estradiol level even
      without body mass changes.
FAU - Plinta, Ryszard
AU  - Plinta R
AD  - Studium Wychowania Fizycznego i Sportu, SIaskiego Uniwersytetu Medycznego w
      Katowicach, Polska. rplinta@sum.edu.pl
FAU - Olszanecka-Glinianowicz, Magdalena
AU  - Olszanecka-Glinianowicz M
FAU - Drosdzol-Cop, Agnieszka
AU  - Drosdzol-Cop A
FAU - Chudek, Jerzy
AU  - Chudek J
FAU - Skrzypulec-Plinta, Violetta
AU  - Skrzypulec-Plinta V
LA  - pol
PT  - Journal Article
TT  - Stan odzywienia i zwyczaje zywieniowe a stezenie estradiolu w surowicy i jego
      zmiany w czasie okresu przygotowawczego do sezonu rozgrywek ligowych u pilkarek
      recznych i koszykarek.
PL  - Poland
TA  - Ginekol Pol
JT  - Ginekologia polska
JID - 0374641
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Athletic Performance/*physiology
MH  - Attitude to Health
MH  - Basketball/*physiology
MH  - Energy Intake/*physiology
MH  - Estradiol/*blood
MH  - Feeding Behavior/*physiology
MH  - Female
MH  - Food Preferences
MH  - Humans
MH  - Menstrual Cycle/blood/*physiology
MH  - Nutritional Status
MH  - Physical Endurance/*physiology
MH  - Young Adult
EDAT- 2013/01/25 06:00
MHDA- 2013/03/02 06:00
CRDT- 2013/01/25 06:00
PHST- 2013/01/25 06:00 [entrez]
PHST- 2013/01/25 06:00 [pubmed]
PHST- 2013/03/02 06:00 [medline]
PST - ppublish
SO  - Ginekol Pol. 2012 Sep;83(9):674-80.


PMID- 23342820
OWN - NLM
STAT- MEDLINE
DCOM- 20130221
LR  - 20190608
IS  - 0027-9684 (Print)
IS  - 0027-9684 (Linking)
VI  - 104
IP  - 9-10
DP  - 2012 Sep-Oct
TI  - Circumcision in the United States: where are we?
PG  - 455-8
AB  - Circumcision is one of the most common surgical procedures performed on males in 
      the United States. Ethical considerations of the procedure have been considered
      for many years and, recently, research on the topic has shed more light on the
      debate. The purpose of this study was to review the history and emergence,
      current demographics, and practices of male circumcision, specifically,
      nonreligious, nonmedically indicated routine neonatal circumcision. A review of
      the current literature was conducted using PubMed and current practices from
      guidelines of major professional societies. Physicians should consider the
      various ethical concerns and provide the patient's guardians with unbiased
      counsel. There is a lack of evidence both in favor of and against recommending
      routine neonatal circumcisions in the United States. The question remains whether
      we should continue unwarranted male circumcisions, especially when the major
      tenet of medical ethics is "do no harm."
FAU - Robinson, John D
AU  - Robinson JD
AD  - Department of Surgery , Howard University Hospital/College of Medicine, 2041
      Georgia Ave NW Washington, DC 20060, USA. jdrobinson@aol.com
FAU - Ortega, Gezzer
AU  - Ortega G
FAU - Carrol, Jarrod A
AU  - Carrol JA
FAU - Townsend, Aimee
AU  - Townsend A
FAU - Carnegie, Daniel A
AU  - Carnegie DA
FAU - Rice, David
AU  - Rice D
FAU - Bennett, Nelson Jr
AU  - Bennett N Jr
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Natl Med Assoc
JT  - Journal of the National Medical Association
JID - 7503090
SB  - IM
MH  - Circumcision, Male/ethics/*statistics & numerical data
MH  - *Ethics, Medical
MH  - Humans
MH  - Male
MH  - United States
EDAT- 2013/01/25 06:00
MHDA- 2013/02/22 06:00
CRDT- 2013/01/25 06:00
PHST- 2013/01/25 06:00 [entrez]
PHST- 2013/01/25 06:00 [pubmed]
PHST- 2013/02/22 06:00 [medline]
AID - S0027-9684(15)30200-5 [pii]
AID - 10.1016/s0027-9684(15)30200-5 [doi]
PST - ppublish
SO  - J Natl Med Assoc. 2012 Sep-Oct;104(9-10):455-8. doi:
      10.1016/s0027-9684(15)30200-5.


PMID- 23342403
OWN - NLM
STAT- MEDLINE
DCOM- 20130620
LR  - 20211021
IS  - 1470-2118 (Print)
IS  - 1470-2118 (Linking)
VI  - 12
IP  - 6
DP  - 2012 Dec
TI  - BMA and NICE guidance on organ retrieval: neither misguided nor presumptuous.
PG  - 517-9
AB  - Organ donation from deceased donors should occur whenever appropriate: that is,
      when there is evidence, belief or understanding that donation was the stated wish
      of the potential donor or would be in accordance with their wishes, is lawful and
      in line with current guidelines and will not add further distress to the family. 
      This is the underlying assumption of the British Medical Association (BMA)
      report, National Institute for Health and Clinical Excellence (NICE) Guideline
      and Welsh Government Assembly Report. For potential donors after circulatory
      death, it might be necessary to support the potential donor until the wishes of
      the person and their family are ascertained. Provided that such interventions are
      reasonable, explained and do not cause distress to the patient and their family, 
      such measures are surely suitable and will also enable donation to occur when
      appropriate. Publication and adherence to guidelines that have clinical, legal
      and ethical validity will reassure the public. Organ donation not only improves
      the length and quality of life of recipients, but also saves resources for the
      NHS and provides benefit to the donor family.
FAU - Neuberger, James
AU  - Neuberger J
AD  - NHS Blood and Transplant, Birmingham. James.Neuberger@nhsbt.nhs.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Med (Lond)
JT  - Clinical medicine (London, England)
JID - 101092853
SB  - IM
CIN - Clin Med (Lond). 2013 Apr;13(2):215. PMID: 23681883
MH  - Health Policy/*legislation & jurisprudence
MH  - Humans
MH  - *Practice Guidelines as Topic
MH  - Presumed Consent/ethics/*legislation & jurisprudence
MH  - *Societies, Medical
MH  - *State Medicine
MH  - Tissue and Organ Harvesting/ethics/*legislation & jurisprudence
MH  - United Kingdom
PMC - PMC5922589
EDAT- 2013/01/25 06:00
MHDA- 2013/06/21 06:00
CRDT- 2013/01/25 06:00
PHST- 2013/01/25 06:00 [entrez]
PHST- 2013/01/25 06:00 [pubmed]
PHST- 2013/06/21 06:00 [medline]
AID - 10.7861/clinmedicine.12-6-517 [doi]
PST - ppublish
SO  - Clin Med (Lond). 2012 Dec;12(6):517-9. doi: 10.7861/clinmedicine.12-6-517.


PMID- 23342402
OWN - NLM
STAT- MEDLINE
DCOM- 20130620
LR  - 20211021
IS  - 1470-2118 (Print)
IS  - 1470-2118 (Linking)
VI  - 12
IP  - 6
DP  - 2012 Dec
TI  - Misguided presumptions: British Medical Association (BMA) and National Institute 
      for Health and Clinical Excellence (NICE) guidance on organ retrieval and 'opt
      out' or 'presumed consent'.
PG  - 513-6
AB  - Three documents have been produced in an attempt to increase the number of organs
      available for transplant: a National Institute for Health and Clinical Excellence
      (NICE) clinical guideline, a British Medical Association (BMA) report and a Welsh
      Government white paper. All three are ethically flawed: NICE and the BMA
      recommend that whenever there is intention to withdraw life-sustaining treatment 
      and death is expected, patients should instead be stabilised to assess for
      donation. This is contrary to patients' best interests, the principles of mental 
      capacity legislation and current criteria for accessing intensive care units.
      Regarding consent, the BMA and Welsh Government recommend an 'opt-out' policy,
      but consent in law requires information and cannot be 'presumed' or 'deemed' on
      the basis of failure to express or register 'opting out'. The language of all
      three proposals is manipulative, and patient trust may be undermined because the 
      doctor's attention must move from the interests of the patient to those of the
      unknown organ recipients.
FAU - Randall, Fiona
AU  - Randall F
AD  - Isle of Wight NHS Trust. fiona.randall@iow.nhs.uk
FAU - Downie, Robin
AU  - Downie R
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Med (Lond)
JT  - Clinical medicine (London, England)
JID - 101092853
SB  - IM
CIN - Clin Med (Lond). 2013 Apr;13(2):215. PMID: 23681883
MH  - Health Policy/*legislation & jurisprudence
MH  - Humans
MH  - *Practice Guidelines as Topic
MH  - Presumed Consent/ethics/*legislation & jurisprudence
MH  - *Societies, Medical
MH  - *State Medicine
MH  - Tissue and Organ Harvesting/ethics/*legislation & jurisprudence
MH  - United Kingdom
PMC - PMC5922588
EDAT- 2013/01/25 06:00
MHDA- 2013/06/21 06:00
CRDT- 2013/01/25 06:00
PHST- 2013/01/25 06:00 [entrez]
PHST- 2013/01/25 06:00 [pubmed]
PHST- 2013/06/21 06:00 [medline]
AID - 10.7861/clinmedicine.12-6-513 [doi]
PST - ppublish
SO  - Clin Med (Lond). 2012 Dec;12(6):513-6. doi: 10.7861/clinmedicine.12-6-513.


PMID- 23342401
OWN - NLM
STAT- MEDLINE
DCOM- 20130620
LR  - 20220331
IS  - 1470-2118 (Print)
IS  - 1470-2118 (Linking)
VI  - 12
IP  - 6
DP  - 2012 Dec
TI  - Prevalence of use of complementary and alternative medicine (CAM) by physicians
      in the UK: a systematic review of surveys.
PG  - 505-12
AB  - This systematic review aims to estimate the prevalence of use of complementary
      and alternative medicine (CAM) by physicians in the UK. Five databases were
      searched for surveys monitoring the prevalence of use of CAM, which were
      published between 1 January 1995 and 7 December 2011. In total, 14 papers that
      reported 13 separate surveys met our inclusion criteria. Most were of poor
      methodological quality. The average prevalence of use of CAM across all surveys
      was 20.6% (range 12.1-32%). The average referral rate to CAM was 39% (range
      24.6-86%), and CAM was recommended by 46% of physicians (range 38-55%). The
      average percentage of physicians who had received training in CAM was 10.3%
      (range 4.8-21%). The three most commonly used methods of CAM were acupuncture,
      homeopathy and relaxation therapy. A sizable proportion of physicians in the UK
      seem to employ some type of CAM, yet many have not received any training in CAM. 
      This raises issues related to medical ethics, professional competence and
      education of physicians.
FAU - Posadzki, Paul
AU  - Posadzki P
AD  - Amani Alotaibi, Complementary Medicine, Peninsula Medical School, Exeter.
      Paul.Posadzki@pcmd.ac.uk
FAU - Alotaibi, Amani
AU  - Alotaibi A
FAU - Ernst, Edzard
AU  - Ernst E
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
PL  - England
TA  - Clin Med (Lond)
JT  - Clinical medicine (London, England)
JID - 101092853
SB  - IM
MH  - Complementary Therapies/*statistics & numerical data
MH  - Health Care Surveys
MH  - Humans
MH  - *Physicians
MH  - Practice Patterns, Physicians'/statistics & numerical data
MH  - United Kingdom
PMC - PMC5922587
EDAT- 2013/01/25 06:00
MHDA- 2013/06/21 06:00
CRDT- 2013/01/25 06:00
PHST- 2013/01/25 06:00 [entrez]
PHST- 2013/01/25 06:00 [pubmed]
PHST- 2013/06/21 06:00 [medline]
AID - 10.7861/clinmedicine.12-6-505 [doi]
PST - ppublish
SO  - Clin Med (Lond). 2012 Dec;12(6):505-12. doi: 10.7861/clinmedicine.12-6-505.


PMID- 23339262
OWN - NLM
STAT- MEDLINE
DCOM- 20130305
LR  - 20130121
IS  - 1931-7093 (Print)
IS  - 1931-7093 (Linking)
VI  - 32
IP  - 6
DP  - 2012 Nov-Dec
TI  - Ethics: treatment claims must match reality, says CEO.
PG  - 8-9
FAU - Grantham, Dennis
AU  - Grantham D
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Behav Healthc
JT  - Behavioral healthcare
JID - 101269325
MH  - Behavior, Addictive/*therapy
MH  - Humans
MH  - Substance Abuse Treatment Centers/*ethics
MH  - United States
EDAT- 2013/01/23 06:00
MHDA- 2013/03/06 06:00
CRDT- 2013/01/23 06:00
PHST- 2013/01/23 06:00 [entrez]
PHST- 2013/01/23 06:00 [pubmed]
PHST- 2013/03/06 06:00 [medline]
PST - ppublish
SO  - Behav Healthc. 2012 Nov-Dec;32(6):8-9.


PMID- 23338674
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 2166-5222 (Print)
IS  - 2166-5222 (Linking)
VI  - 5
IP  - 2
DP  - 2012
TI  - Racial and Ethnic Health Disparities in Incarcerated Populations.
PG  - 92-100
AB  - Alarming disparities in population health and wellness in the United States have 
      led to multidisciplinary research efforts to create health equity. Identifying
      disparities, elucidating the etiological bases of disparities, and implementing
      solutions to eliminate disparities are part of the U.S. national health agenda.
      Racial and ethnic disparities have been identified throughout the cancer control 
      continuum, in cardiovascular disease, diabetes and a multitude of other
      conditions. The causes of disparities are complex, condition specific, and
      conjectured to result from combinations of biological and socio-behavioral
      factors. Racial and ethnic health disparities within the vast incarcerated
      communities have been excluded from most studies, yet are of significant ethical 
      and fiscal concern to inmates, governing bodies, and non-incarcerated communities
      into which inmates return. Importantly, research on racial and ethnic disparities
      in this unique population may shed light on the relative etiologies of health
      disparities and solutions for creating health equity throughout the general
      population in the United States.
FAU - Borysova, Meghan E
AU  - Borysova ME
AD  - University of Florida.
FAU - Mitchell, Ojmarrh
AU  - Mitchell O
FAU - Sultan, Dawood H
AU  - Sultan DH
FAU - Williams, Arthur R
AU  - Williams AR
LA  - eng
GR  - P20 MD003375/MD/NIMHD NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - J Health Dispar Res Pract
JT  - Journal of health disparities research and practice
JID - 101513539
PMC - PMC3546523
MID - NIHMS430960
EDAT- 2013/01/23 06:00
MHDA- 2013/01/23 06:01
CRDT- 2013/01/23 06:00
PHST- 2013/01/23 06:00 [entrez]
PHST- 2013/01/23 06:00 [pubmed]
PHST- 2013/01/23 06:01 [medline]
PST - ppublish
SO  - J Health Dispar Res Pract. 2012;5(2):92-100.


PMID- 23338647
OWN - NLM
STAT- MEDLINE
DCOM- 20140121
LR  - 20191112
IS  - 1726-4642 (Electronic)
IS  - 1726-4634 (Linking)
VI  - 29
IP  - 4
DP  - 2012 Oct-Dec
TI  - [Reasons for an intercultural perspective of bioethics].
PG  - 566-9
LID - S1726-46342012000400024 [pii]
AB  - Bioethics must have an intercultural perspective. This is based on three facts:
      The principles and values around which reflection is made are related to world
      views and traditions, human beings are cultural beings, and current societies are
      considerably diverse. Based on this, bioethics will seek an adequate balance
      between ethical universalism and contextualism. This is a fundamental step for
      unconditional respect for human dignity and mutual recognition, dialogue,
      correlation and complementarity among diverse cultures.
FAU - Chavez Aguilar, Pamela
AU  - Chavez Aguilar P
AD  - Universidad de Chile, Santiago de Chile, Chile. pchavez@u.uchile.cl
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Razones para una perspectiva intercultural en bioetica.
PL  - Peru
TA  - Rev Peru Med Exp Salud Publica
JT  - Revista peruana de medicina experimental y salud publica
JID - 101227566
SB  - IM
MH  - *Bioethics
MH  - *Cultural Characteristics
EDAT- 2013/01/23 06:00
MHDA- 2014/01/22 06:00
CRDT- 2013/01/23 06:00
PHST- 2012/06/19 00:00 [received]
PHST- 2012/11/14 00:00 [accepted]
PHST- 2013/01/23 06:00 [entrez]
PHST- 2013/01/23 06:00 [pubmed]
PHST- 2014/01/22 06:00 [medline]
AID - S1726-46342012000400024 [pii]
AID - 10.1590/s1726-46342012000400024 [doi]
PST - ppublish
SO  - Rev Peru Med Exp Salud Publica. 2012 Oct-Dec;29(4):566-9. doi:
      10.1590/s1726-46342012000400024.


PMID- 23338641
OWN - NLM
STAT- MEDLINE
DCOM- 20140121
LR  - 20211021
IS  - 1726-4642 (Electronic)
IS  - 1726-4634 (Linking)
VI  - 29
IP  - 4
DP  - 2012 Oct-Dec
TI  - [Ethical challenges of genetic manipulation and research with animals].
PG  - 535-40
LID - S1726-46342012000400018 [pii]
AB  - Research with animals presents ethical questions both for being used as models of
      human diseases and for being a prerequisite for trials in humans, as in the
      introduction of genetic modifications. Some of these questions refer to the fact 
      that, as models, they do not fully represent the human condition; that conducting
      toxicity tests causes great harm to animals; that their nature is altered by
      genetic modifications and that introducing genetically modified organisms is a
      risk. The use of animals in research for the benefit of humans imposes the moral 
      responsibility to respect them, not making them suffer unnecessarily, since they 
      are living beings capable of feeling.
FAU - Rodriguez Yunta, Eduardo
AU  - Rodriguez Yunta E
AD  - Universidad de Chile, Santiago, Chile. erodriguezchi@gmail.com
LA  - spa
GR  - R25 TW006056/TW/FIC NIH HHS/United States
PT  - English Abstract
PT  - Journal Article
TT  - Desafios eticos de la manipulacion genetica y la investigacion con animales.
PL  - Peru
TA  - Rev Peru Med Exp Salud Publica
JT  - Revista peruana de medicina experimental y salud publica
JID - 101227566
SB  - IM
MH  - Animal Experimentation/*ethics
MH  - Animal Welfare/ethics
MH  - Animals
MH  - Animals, Genetically Modified
MH  - Bioethical Issues
MH  - Genetic Research/*ethics
PMC - PMC3711750
MID - NIHMS418135
EDAT- 2013/01/23 06:00
MHDA- 2014/01/22 06:00
CRDT- 2013/01/23 06:00
PHST- 2012/09/10 00:00 [received]
PHST- 2012/11/14 00:00 [accepted]
PHST- 2013/01/23 06:00 [entrez]
PHST- 2013/01/23 06:00 [pubmed]
PHST- 2014/01/22 06:00 [medline]
AID - S1726-46342012000400018 [pii]
AID - 10.1590/s1726-46342012000400018 [doi]
PST - ppublish
SO  - Rev Peru Med Exp Salud Publica. 2012 Oct-Dec;29(4):535-40. doi:
      10.1590/s1726-46342012000400018.


PMID- 23338640
OWN - NLM
STAT- MEDLINE
DCOM- 20140121
LR  - 20191112
IS  - 1726-4642 (Electronic)
IS  - 1726-4634 (Linking)
VI  - 29
IP  - 4
DP  - 2012 Oct-Dec
TI  - [Do clinical trials contribute to research development in Peru? How can that be
      achieved?].
PG  - 529-34
LID - S1726-46342012000400017 [pii]
AB  - The participation of the National Institute of Health as a leader in ethical and 
      methodological assessment and its responsibility to approve the implementation of
      studies dates back to 1995. Since then, clinical trials have increased
      significantly until 2009; for this reason, a preliminary analysis was made to
      assess whether this increase has had an impact in the production of clinical
      trials on endemic topics or disease burden problems that must be researched and
      resolved by Peruvian people. For this purpose, a search in SCOPUS and MEDLINE was
      conducted, with 102 clinical trials in humans found, all of them designed,
      implemented and carried out in Peru on endemic or domestic health issues.
      Observation over time does not reveal any parallel increase or the inclusion of
      new research groups or researchers, no research on endemic problems has been
      carried out in our country; for example, clinical trials on the "Carrion's
      Disease" have not been conducted. Very few clinical trials have been promoted
      during this period by academic institutions and the civil society. Taking this
      into consideration, we can affirm that there is no positive influence in the
      generation of native clinical trials on local problems that Peruvian people need 
      to resolve.
FAU - Malaga, German
AU  - Malaga G
AD  - CRONICAS Centro de Excelencia en enfermedades cronicas, Universidad Peruana
      Cayetano Heredia, Lima, Peru. german.malaga@upch.pe
FAU - Zuniga-Rivera, Ana
AU  - Zuniga-Rivera A
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - inverted question markContribuyen los ensayos clinicos al desarrollo de la
      investigacion en el Peru? inverted question markComo lograrlo?
PL  - Peru
TA  - Rev Peru Med Exp Salud Publica
JT  - Revista peruana de medicina experimental y salud publica
JID - 101227566
SB  - IM
MH  - *Biomedical Research/methods
MH  - *Clinical Trials as Topic
MH  - Humans
MH  - Peru
EDAT- 2013/01/23 06:00
MHDA- 2014/01/22 06:00
CRDT- 2013/01/23 06:00
PHST- 2012/11/04 00:00 [received]
PHST- 2012/11/14 00:00 [accepted]
PHST- 2013/01/23 06:00 [entrez]
PHST- 2013/01/23 06:00 [pubmed]
PHST- 2014/01/22 06:00 [medline]
AID - S1726-46342012000400017 [pii]
AID - 10.1590/s1726-46342012000400017 [doi]
PST - ppublish
SO  - Rev Peru Med Exp Salud Publica. 2012 Oct-Dec;29(4):529-34. doi:
      10.1590/s1726-46342012000400017.


PMID- 23338639
OWN - NLM
STAT- MEDLINE
DCOM- 20140121
LR  - 20191112
IS  - 1726-4642 (Electronic)
IS  - 1726-4634 (Linking)
VI  - 29
IP  - 4
DP  - 2012 Oct-Dec
TI  - [Development of new drugs: opportunities and benefits for Peru].
PG  - 521-8
LID - S1726-46342012000400016 [pii]
AB  - The development of innovative drugs allows coming up with new medicines to
      prevent and better treat illnesses. This improves people's quality of life and
      makes it more productive. Therefore, the mission of pharmaceutical research is to
      develop safe and effective drugs. Clinical trials allow the evaluation of the
      safety and efficacy profiles of new medicines, medical devices and diagnostic
      tests. Research and development (R&D) of new drugs is a long and costly process, 
      where out of every 5000 to 10000 new components that enter preclinical testing,
      only one is approved. Compared to 2011, drug development has increased by 7.6%.
      According to ClinicalTrials.gov, 5% of the trials take place in Latin America,
      and Peru is in the fifth position. On the other hand, according to the Global
      Competitiveness Report issued by the World Economic Forum, Peru ranks 61st, its
      biggest challenges being the functioning of its public institutions, investment
      in R&D and technological capacity. The complexity of drug R&D results in a search
      for competitive places to develop clinical trials. Clinical Research is a
      humanized industry due to its ethical platform, stated in the guidelines of good 
      clinical practices. This industry demands our country to develop a
      differentiating value that contributes to the development of knowledge and its
      competitiveness.
FAU - Bayona, Andres
AU  - Bayona A
AD  - Asociacion Peruana de Organizaciones de Investigacion Clinica por Contrato, Lima,
      Peru. andres.bayona@pucp.edu.pe
FAU - Fajardo, Natalia
AU  - Fajardo N
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Desarrollo de nuevos medicamentos: oportunidades y beneficios para el Peru
PL  - Peru
TA  - Rev Peru Med Exp Salud Publica
JT  - Revista peruana de medicina experimental y salud publica
JID - 101227566
RN  - 0 (Drugs, Investigational)
SB  - IM
CIN - Rev Peru Med Exp Salud Publica. 2013 Mar;30(1):156-7. PMID: 23612840
MH  - Biomedical Research
MH  - Clinical Trials as Topic
MH  - *Drugs, Investigational
MH  - Humans
MH  - Peru
EDAT- 2013/01/23 06:00
MHDA- 2014/01/22 06:00
CRDT- 2013/01/23 06:00
PHST- 2012/10/22 00:00 [received]
PHST- 2012/10/31 00:00 [accepted]
PHST- 2013/01/23 06:00 [entrez]
PHST- 2013/01/23 06:00 [pubmed]
PHST- 2014/01/22 06:00 [medline]
AID - S1726-46342012000400016 [pii]
AID - 10.1590/s1726-46342012000400016 [doi]
PST - ppublish
SO  - Rev Peru Med Exp Salud Publica. 2012 Oct-Dec;29(4):521-8. doi:
      10.1590/s1726-46342012000400016.


PMID- 23338638
OWN - NLM
STAT- MEDLINE
DCOM- 20140121
LR  - 20191112
IS  - 1726-4642 (Electronic)
IS  - 1726-4634 (Linking)
VI  - 29
IP  - 4
DP  - 2012 Oct-Dec
TI  - [Role of the state as regulatory authority of clinical trials in Peru].
PG  - 516-20
LID - S1726-46342012000400015 [pii]
AB  - This article sheds the light on historical review of the clinical trials
      regulatory process to the publication of the Clinical Trials Regulation in Peru, 
      by Supreme Decree 017-2006-SA. In this context, that Regulation was amended
      within one year, with many critics including from the Ombudsman. It also
      considers the achievements as a regulatory authority that has strengthened its
      steering and its main objective of protecting the rights, safety and welfare of
      human subjects in clinical trials. Those achievements are: the internal register 
      of clinical trials, strengthening inspections on all stakeholders that take part 
      in research, the Notification System of Serious Adverse Events (REAS-NET), the
      publication of the Guideline: "Ethical, Legal and methodology in clinical trials 
      for use of the Ethical Review Board" which won an international award; the 1st
      prize in the category of fizcalization and accomplishment of the law by the Good 
      Practice of Public Management: "Protecting the rights of human subjects in
      experimental studies", the publication of the new Manual of Procedures for
      Clinical Trials and the implementation Plan of the National Bioethics Network in 
      Peru.
FAU - Fuentes, Duilio
AU  - Fuentes D
AD  - Direccion General de Investigacion y Transferencia Tecnologica, Instituto
      Nacional de Salud, Lima, Peru. dfuentes@ins.gob.pe
FAU - Minaya, Gabriela
AU  - Minaya G
FAU - Ayala-Quintanilla, Beatriz
AU  - Ayala-Quintanilla B
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Rol del estado como autoridad reguladora de ensayos clinicos en el Peru
PL  - Peru
TA  - Rev Peru Med Exp Salud Publica
JT  - Revista peruana de medicina experimental y salud publica
JID - 101227566
SB  - IM
CIN - Rev Peru Med Exp Salud Publica. 2013 Mar;30(1):148-9. PMID: 23612833
MH  - Clinical Trials as Topic/*legislation & jurisprudence/*standards
MH  - *Government
MH  - Humans
MH  - Patient Rights
MH  - Peru
MH  - Role
EDAT- 2013/01/23 06:00
MHDA- 2014/01/22 06:00
CRDT- 2013/01/23 06:00
PHST- 2012/11/14 00:00 [received]
PHST- 2012/11/28 00:00 [accepted]
PHST- 2013/01/23 06:00 [entrez]
PHST- 2013/01/23 06:00 [pubmed]
PHST- 2014/01/22 06:00 [medline]
AID - S1726-46342012000400015 [pii]
AID - 10.1590/s1726-46342012000400015 [doi]
PST - ppublish
SO  - Rev Peru Med Exp Salud Publica. 2012 Oct-Dec;29(4):516-20. doi:
      10.1590/s1726-46342012000400015.


PMID- 23338637
OWN - NLM
STAT- MEDLINE
DCOM- 20140121
LR  - 20191112
IS  - 1726-4642 (Electronic)
IS  - 1726-4634 (Linking)
VI  - 29
IP  - 4
DP  - 2012 Oct-Dec
TI  - [Role of government in clinical trials].
PG  - 509-15
LID - S1726-46342012000400014 [pii]
AB  - The regulation of clinical trials by the Government is a process of continuous
      change and adaptation, current challenge is to ensure the safety of participants 
      and get balance of administrative procedures. Development and regulation of
      clinical trials in different countries vary according to the situation, context
      national or international execution, determining the insufficiency of national
      regulation requiring review of international regulation. The aim of this
      publication is to present a comprehensive overview of the role of Government in
      the regulation of clinical trials in different realities. It includes a review of
      the regulation in The European Union, The United States and some Latin American
      countries and finally the regulation in Peru. Contemporary trends in the
      regulation of clinical trials, are characterized by increasing standards of
      quality, ensuring the safety of the participants, promote transparency, lower
      bureaucratic processes and strengthening ethics IRB committees in the framework
      of open democratic processes, involving all stakeholders in dynamic processes
      based on current knowledge and changing tendencies. The challenge is to promote
      the development of clinical trials from the government institutions
      (universities, research centers, institutes, hospitals, etc.) priorizing local
      needs including orphan drugs, prevalent and neglected diseases, and therapeutic
      use of active components of local native plants.
FAU - Mazzetti, Pilar
AU  - Mazzetti P
AD  - Centro de Investigacion en Neurogenetica, Instituto Nacional de Ciencias
      Neurologicas, Lima, Peru. peru.neurogenetica@gmail.com
FAU - Silva-Paredes, Gustavo
AU  - Silva-Paredes G
FAU - Cornejo-Olivas, Mario
AU  - Cornejo-Olivas M
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
TT  - Rol del estado en los ensayos clinicos.
PL  - Peru
TA  - Rev Peru Med Exp Salud Publica
JT  - Revista peruana de medicina experimental y salud publica
JID - 101227566
SB  - IM
MH  - Clinical Trials as Topic/*legislation & jurisprudence/*standards
MH  - *Government
MH  - Humans
MH  - Role
EDAT- 2013/01/23 06:00
MHDA- 2014/01/22 06:00
CRDT- 2013/01/23 06:00
PHST- 2012/10/17 00:00 [received]
PHST- 2012/10/31 00:00 [accepted]
PHST- 2013/01/23 06:00 [entrez]
PHST- 2013/01/23 06:00 [pubmed]
PHST- 2014/01/22 06:00 [medline]
AID - S1726-46342012000400014 [pii]
AID - 10.1590/s1726-46342012000400014 [doi]
PST - ppublish
SO  - Rev Peru Med Exp Salud Publica. 2012 Oct-Dec;29(4):509-15. doi:
      10.1590/s1726-46342012000400014.


PMID- 23338583
OWN - NLM
STAT- MEDLINE
DCOM- 20140121
LR  - 20190911
IS  - 1984-0446 (Electronic)
IS  - 0034-7167 (Linking)
VI  - 65
IP  - 5
DP  - 2012 Sep-Oct
TI  - [Fathers' experiences during the hospitalization of the premature newborn in the 
      Neonatal Intensive Care Unit].
PG  - 788-94
LID - S0034-71672012000500011 [pii]
AB  - This study aimed to understand the fathers' experiences during the
      hospitalization of premature newborn in the Neonatal Intensive Care Unit at a
      public hospital in Feira de Santana, Bahia. This is a qualitative descriptive
      exploratory study that was approved by the Ethics Committee of the Faculty of
      Technology and Sciences, and carried out in a public hospital in Bahia, with nine
      fathers who accompanied their children hospitalized in the Neonatal Intensive
      Care Unit. The data were analyzed through content analysis. The results showed
      that premature births cause feelings of surprise, anxiety and fear in the
      fathers. It is needed rethink how does the inclusion of premature infants'
      fathers in the hospitalization process and about the changes in established
      routines for the visit and paternal participation in the context of premature
      care.
FAU - Santos, Luciano Marques
AU  - Santos LM
AD  - Universidade Federal do Vale do Sao Francisco, Feira de Santana, BA, Brasil.
      luciano.marques@univasf.edu.br
FAU - Silva, Cintia Lorena de Souza
AU  - Silva CL
FAU - Santana, Rosana Castelo Branco de
AU  - Santana RC
FAU - Santos, Vivane Euzebia Pereira
AU  - Santos VE
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Vivencias paternas durante a hospitalizacao do recem-nascido prematuro na Unidade
      de Terapia Intensiva Neonatal.
PL  - Brazil
TA  - Rev Bras Enferm
JT  - Revista brasileira de enfermagem
JID - 7910105
MH  - Fathers/*psychology
MH  - Hospitalization
MH  - Humans
MH  - Infant, Newborn
MH  - *Infant, Premature
MH  - Intensive Care Units, Neonatal
MH  - Male
EDAT- 2013/01/23 06:00
MHDA- 2014/01/22 06:00
CRDT- 2013/01/23 06:00
PHST- 2011/02/28 00:00 [received]
PHST- 2012/11/27 00:00 [accepted]
PHST- 2013/01/23 06:00 [entrez]
PHST- 2013/01/23 06:00 [pubmed]
PHST- 2014/01/22 06:00 [medline]
AID - S0034-71672012000500011 [pii]
AID - 10.1590/s0034-71672012000500011 [doi]
PST - ppublish
SO  - Rev Bras Enferm. 2012 Sep-Oct;65(5):788-94. doi: 10.1590/s0034-71672012000500011.


PMID- 23337828
OWN - NLM
STAT- MEDLINE
DCOM- 20140418
LR  - 20211203
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 98
DP  - 2013 Dec
TI  - 'Give us the full story': overcoming the challenges to achieving informed choice 
      about fetal anomaly screening in Australian Aboriginal communities.
PG  - 351-60
LID - 10.1016/j.socscimed.2012.10.031 [doi]
LID - S0277-9536(12)00831-3 [pii]
AB  - This cross-cultural qualitative study examined the ethical, language and cultural
      complexities around offering fetal anomaly screening in Australian Aboriginal
      communities. There were five study sites across the Northern Territory (NT),
      including urban and remote Aboriginal communities. In-depth interviews were
      conducted between October 2009 and August 2010, and included 35 interviews with
      59 health providers and 33 interviews with 62 Aboriginal women. The findings show
      that while many providers espoused the importance of achieving equity in access
      to fetal anomaly screening, their actions were inconsistent with this ideal.
      Providers reported they often modified their practice depending on the
      characteristics of their client, including their English skills, the perception
      of the woman's interest in the tests and assumptions based on their risk profile 
      and cultural background. Health providers were unsure whether it was better to
      tailor information to the specific needs of their client or to provide the same
      level of information to all clients. Very few Aboriginal women were aware of
      fetal anomaly screening. The research revealed they did want to be offered
      screening and wanted the 'full story' about all aspects of the tests. The
      communication processes advocated by Aboriginal women to improve understanding
      about screening included community discussions led by elders and educators. These
      processes promote culturally defined ways of sharing information, rather than the
      individualised, biomedical approaches to information-giving in the clinical
      setting. A different and arguably more ethical approach to introducing fetal
      anomaly screening would be to initiate dialogue with appropriate groups of women 
      in the community, particularly young women, build relationships and utilise
      Aboriginal health workers. This could accommodate individual choice and broader
      cultural values and allow women to discuss the moral and philosophical debates
      surrounding fetal anomaly screening prior to the clinical encounter and within
      their own cultural space.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Wild, Kayli
AU  - Wild K
AD  - Menzies School of Health Research, Charles Darwin University, Australia.
      Electronic address: k.wild@latrobe.edu.au.
FAU - Maypilama, Elaine Lawurrpa
AU  - Maypilama EL
AD  - Menzies School of Health Research, Charles Darwin University, Australia; Yalu
      Marnggithinyaraw Centre, Elcho Island, Australia.
FAU - Kildea, Sue
AU  - Kildea S
AD  - Australian Catholic University, Australia; Mater Mothers' Hospital, Australia.
FAU - Boyle, Jacqueline
AU  - Boyle J
AD  - Faculty of Medicine, Nursing and Health Sciences, Monash University, Australia.
FAU - Barclay, Lesley
AU  - Barclay L
AD  - University Centre for Rural Health, University of Sydney, Australia.
FAU - Rumbold, Alice
AU  - Rumbold A
AD  - Menzies School of Health Research, Charles Darwin University, Australia;
      Discipline of Obstetrics and Gynaecology, University of Adelaide, Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121220
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Attitude to Health/*ethnology
MH  - Australia
MH  - Choice Behavior
MH  - *Communication
MH  - Female
MH  - Humans
MH  - Informed Consent/*psychology
MH  - Native Hawaiian or Other Pacific Islander/*psychology/statistics & numerical data
MH  - *Needs Assessment
MH  - *Physician-Patient Relations
MH  - Pregnancy
MH  - Prenatal Diagnosis/*statistics & numerical data
MH  - Qualitative Research
OTO - NOTNLM
OT  - Aboriginal health
OT  - Australia
OT  - Down syndrome
OT  - Fetal anomaly screening
OT  - Health communication
OT  - Prenatal genetic testing
OT  - Reproductive health
EDAT- 2013/01/23 06:00
MHDA- 2014/04/20 06:00
CRDT- 2013/01/23 06:00
PHST- 2012/02/06 00:00 [received]
PHST- 2012/10/19 00:00 [revised]
PHST- 2012/10/26 00:00 [accepted]
PHST- 2013/01/23 06:00 [entrez]
PHST- 2013/01/23 06:00 [pubmed]
PHST- 2014/04/20 06:00 [medline]
AID - S0277-9536(12)00831-3 [pii]
AID - 10.1016/j.socscimed.2012.10.031 [doi]
PST - ppublish
SO  - Soc Sci Med. 2013 Dec;98:351-60. doi: 10.1016/j.socscimed.2012.10.031. Epub 2012 
      Dec 20.


PMID- 23337421
OWN - NLM
STAT- MEDLINE
DCOM- 20130909
LR  - 20130311
IS  - 1472-6491 (Electronic)
IS  - 1472-6483 (Linking)
VI  - 26
IP  - 3
DP  - 2013 Mar
TI  - Ethical arguments for and against sperm sorting for non-medical sex selection: a 
      review.
PG  - 231-9
LID - 10.1016/j.rbmo.2012.11.007 [doi]
LID - S1472-6483(12)00692-X [pii]
AB  - Much has been written about the ethics of sex selection. This article thoroughly 
      explores the ethical arguments put forth in the literature both for and against
      non-medical sex selection using sperm sorting. While most of these arguments come
      from philosophers, feminist scholars, social scientists and members of the
      healthcare community, they are often echoed in empirical studies that have
      explored community values. This review is timely because the first efficacious
      method for sex selection via sperm sorting, MicroSort, is currently in clinical
      trials and moving closer to FDA approval for marketing in the USA. While the
      clinical trials are currently focused on the use of MicroSort to avoid X-linked
      genetic diseases, MicroSort can also be used to satisfy parental preferences.
CI  - Copyright (c) 2012 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All
      rights reserved.
FAU - Kalfoglou, A L
AU  - Kalfoglou AL
AD  - University of Maryland, Baltimore County (UMBC), 1000 Hilltop Circle, Health
      Administration and Policy Program, PUP 212, Baltimore, MD 21250, United States.
      akalfogl@umbc.edu
FAU - Kammersell, M
AU  - Kammersell M
FAU - Philpott, S
AU  - Philpott S
FAU - Dahl, E
AU  - Dahl E
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121124
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
SB  - IM
MH  - Clinical Trials as Topic
MH  - Female
MH  - Flow Cytometry/*ethics/methods
MH  - Genetic Diseases, X-Linked/prevention & control
MH  - Human Rights
MH  - Humans
MH  - Male
MH  - Reproductive Techniques, Assisted
MH  - Sex Preselection/*ethics
MH  - Sex Ratio
MH  - Social Values
MH  - Spermatozoa/*cytology
EDAT- 2013/01/23 06:00
MHDA- 2013/09/10 06:00
CRDT- 2013/01/23 06:00
PHST- 2012/10/08 00:00 [received]
PHST- 2012/11/03 00:00 [revised]
PHST- 2012/11/15 00:00 [accepted]
PHST- 2013/01/23 06:00 [entrez]
PHST- 2013/01/23 06:00 [pubmed]
PHST- 2013/09/10 06:00 [medline]
AID - S1472-6483(12)00692-X [pii]
AID - 10.1016/j.rbmo.2012.11.007 [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2013 Mar;26(3):231-9. doi: 10.1016/j.rbmo.2012.11.007. Epub
      2012 Nov 24.


PMID- 23337419
OWN - NLM
STAT- MEDLINE
DCOM- 20131101
LR  - 20191210
IS  - 1472-6491 (Electronic)
IS  - 1472-6483 (Linking)
VI  - 26
IP  - 4
DP  - 2013 Apr
TI  - Compliance with donor age recommendations in oocyte donor recruitment
      advertisements in the USA.
PG  - 400-5
LID - 10.1016/j.rbmo.2012.11.011 [doi]
LID - S1472-6483(12)00696-7 [pii]
AB  - IVF using donated oocytes offers benefits to many infertile patients, yet the
      technique also raises a number of ethical concerns, including worries about
      potential physical and psychological risks to oocyte donors. In the USA,
      oversight of oocyte donation consists of a combination of federal and state
      regulations and self-regulatory guidelines promulgated by the American Society
      for Reproductive Medicine. This study assesses compliance with one of these
      self-regulatory guidelines - specifically, ASRM's preferred minimum age for
      donors of 21. To assess compliance, 539 oocyte donor recruitment advertisements
      from two recruitment channels (Craigslist and college newspapers) were collected 
      and evaluated. Of these, 61% in the Craigslist dataset and 43% in the college
      newspaper dataset listed minimum ages between 18 and 20, which is inconsistent
      with ASRM's preferred minimum age recommendation of 21. Advertisements placed by 
      oocyte donor recruitment agencies were more likely than advertisements placed by 
      clinics to specify minimum ages between 18 and 20. These results indicate that
      ASRM should evaluate and consider revising its donor age guidelines. IVF using
      donated human eggs can help many patients who have difficulty having children.
      However, the technique also raises ethical concerns, including concerns about
      potential physical and psychological harms to egg donors. In the USA, oversight
      of egg donation relies on a combination of federal and state regulation and
      professional self-regulation. Governmental regulations address only limited
      aspects of egg donation, such as the potential spread of infectious diseases and 
      the reporting of success rates, leaving voluntary guidelines developed by an
      association of medical professionals to address most issues, including ethical
      concerns raised by the practice. One of these voluntary guidelines recommends
      that egg donors should be at least 21 years of age. In this article, we analysed 
      539 egg donor recruitment advertisements published on Craigslist and in college
      newspapers to see whether fertility clinics and egg donor recruitment agencies
      follow this recommendation. We found that 61% of advertisements in the Craigslist
      dataset and 43% of advertisements in the college newspaper dataset listed minimum
      ages between 18 and 20 and, thus, did not follow the recommendation that egg
      donors be at least 21 years of age. Advertisements placed by egg donor
      recruitment agencies were more likely than advertisements placed by fertility
      clinics to list minimum ages between 18 and 20. These results indicate that the
      American Society for Reproductive Medicine should evaluate and consider revising 
      its donor age guidelines.
CI  - Copyright (c) 2012 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All
      rights reserved.
FAU - Alberta, Hillary B
AU  - Alberta HB
AD  - School of Public Policy, Georgia Institute of Technology, 685 Cherry Street,
      Atlanta, GA 30332-0345, United States.
FAU - Berry, Roberta M
AU  - Berry RM
FAU - Levine, Aaron D
AU  - Levine AD
LA  - eng
PT  - Journal Article
DEP - 20121201
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Advertising
MH  - Age Factors
MH  - Female
MH  - *Guideline Adherence
MH  - Humans
MH  - Internet
MH  - Oocyte Donation/*ethics
MH  - Social Control, Formal
MH  - United States
EDAT- 2013/01/23 06:00
MHDA- 2013/11/02 06:00
CRDT- 2013/01/23 06:00
PHST- 2012/09/16 00:00 [received]
PHST- 2012/11/04 00:00 [revised]
PHST- 2012/11/15 00:00 [accepted]
PHST- 2013/01/23 06:00 [entrez]
PHST- 2013/01/23 06:00 [pubmed]
PHST- 2013/11/02 06:00 [medline]
AID - S1472-6483(12)00696-7 [pii]
AID - 10.1016/j.rbmo.2012.11.011 [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2013 Apr;26(4):400-5. doi: 10.1016/j.rbmo.2012.11.011. Epub
      2012 Dec 1.


PMID- 23336280
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140611
LR  - 20130122
IS  - 0255-7053 (Print)
IS  - 0255-7053 (Linking)
VI  - 42
IP  - 4
DP  - 2012 Jul
TI  - [New evidence for the author of the medical ethics novel Doctor's Mirror].
PG  - 231-7
AB  - Yijiejing (Doctor's Mirror), the first novel focused on medical ethics in the
      late Qing dynasty, aimed at meliorating medical ethical atmosphere by criticizing
      disorders among medical practitioners. Some contents of this novel were the same 
      as those in Yijie Xianxingji (Revelation of Medical Community). By comparison
      between the two books and investigation on Doctor's Mirror's introduction,
      preface and advertisement in the newspaper at that time, we could find that the
      author of Doctor's Mirror was not the novelist LU Shi-e, but YU Wen-yao, the
      author of Yijie Xianxingji. Distribution of Yijie Xianxingji was stopped soon
      after its publication by the Commercial Press for its allusion to a famous doctor
      in Shanghai. Two years later, YU made some slight modifications the details of
      the novel's characters and his book was published with a different title Doctor's
      Mirror and the pen-name 'medical hermit among scholars'.
FAU - Yang, Fang
AU  - Yang F
AD  - The humanities & Social Sciences School of Anhui Medical University, Hefei,
      230032, China.
FAU - Zhu, Hui
AU  - Zhu H
FAU - Pan, Rong-Hua
AU  - Pan RH
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Shi Za Zhi
JT  - Zhonghua yi shi za zhi (Beijing, China : 1980)
JID - 8303081
EDAT- 2013/01/23 06:00
MHDA- 2013/01/23 06:01
CRDT- 2013/01/23 06:00
PHST- 2013/01/23 06:00 [entrez]
PHST- 2013/01/23 06:00 [pubmed]
PHST- 2013/01/23 06:01 [medline]
PST - ppublish
SO  - Zhonghua Yi Shi Za Zhi. 2012 Jul;42(4):231-7.


PMID- 23336092
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 2161-3303 (Print)
IS  - 2161-3303 (Linking)
VI  - 1
IP  - 4
DP  - 2012 Dec 1
TI  - Ethical and Psychosocial Impact of Female Infertility.
PG  - 153-158
AB  - This manuscript reviews research from the past year on the ethical and
      psychosocial impact of infertility on women and men. We discuss several issues
      surrounding ovarian stimulation, particularly high-order multiple births, egg
      banking (especially for research purposes), and diminished ovarian reserve. We
      also present recent work on distress and counseling, which includes greater
      attention to subgroups of infertile women. More research on issues confronting
      men has emerged recently, and we outline these with regard to their relationships
      with infertile women, or as the infertility patient. Last, we outline some
      ethical issues posed by newer procedures of fertility preservation and uterine
      transplant.
FAU - Leyser-Whalen, Ophra
AU  - Leyser-Whalen O
AD  - Department of Sociology and Anthropology, The University of Texas at El Paso, Old
      Main Bldg., El Paso, TX 79968, USA.
FAU - Temple, Jeff R
AU  - Temple JR
FAU - Phelps, John Y
AU  - Phelps JY
LA  - eng
GR  - T32 HD055163/HD/NICHD NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Curr Obstet Gynecol Rep
JT  - Current obstetrics and gynecology reports
JID - 101579335
PMC - PMC3547399
MID - NIHMS405809
EDAT- 2013/01/22 06:00
MHDA- 2013/01/22 06:01
CRDT- 2013/01/22 06:00
PHST- 2013/01/22 06:00 [entrez]
PHST- 2013/01/22 06:00 [pubmed]
PHST- 2013/01/22 06:01 [medline]
AID - 10.1007/s13669-012-0023-6 [doi]
PST - ppublish
SO  - Curr Obstet Gynecol Rep. 2012 Dec 1;1(4):153-158. doi: 10.1007/s13669-012-0023-6.


PMID- 23331603
OWN - NLM
STAT- MEDLINE
DCOM- 20130820
LR  - 20130121
IS  - 1467-1107 (Electronic)
IS  - 1047-9511 (Linking)
VI  - 22
IP  - 6
DP  - 2012 Dec
TI  - The role of research for sustainable paediatric cardiac programmes in developing 
      countries.
PG  - 787-95
LID - 10.1017/S1047951112001989 [doi]
AB  - Significant challenges face developing countries as a result of the
      maldistribution of access to healthcare throughout the world, specifically access
      to paediatric cardiac care. Sustainable paediatric cardiac programmes must be
      established in developing countries to provide care to all children with
      congenital heart disease. Education and research are essential components to
      sustainable paediatric cardiac programmes in developing countries to define local
      problems and the incidence of disease, and to generate solutions thereto related.
      Research can contribute to developing local expertise, improving technology,
      providing opportunities for local talent, generating financial resources,
      enhancing the dignity of people, and the facilitating resolution of health
      problems throughout the world. Clinical trials conducted in developing countries 
      should meet the same ethical standards as trials based in developed countries.
FAU - Mavroudis, Constantine D
AU  - Mavroudis CD
AD  - Division of Cardiothoracic Surgery, Department of Surgery, University of
      Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
      Constantine.Mavroudis.MD@flhosp.org
FAU - Mavroudis, Constantine
AU  - Mavroudis C
FAU - Jacobs, Jeffrey P
AU  - Jacobs JP
FAU - Siegel, Allison
AU  - Siegel A
LA  - eng
PT  - Journal Article
PL  - England
TA  - Cardiol Young
JT  - Cardiology in the young
JID - 9200019
SB  - IM
MH  - *Biomedical Research
MH  - *Cardiology
MH  - *Developing Countries
MH  - Healthcare Disparities
MH  - Heart Defects, Congenital/*surgery
MH  - Humans
MH  - *Pediatrics
MH  - Program Evaluation
MH  - Risk Assessment
MH  - Societies, Medical
EDAT- 2013/01/22 06:00
MHDA- 2013/08/21 06:00
CRDT- 2013/01/22 06:00
PHST- 2013/01/22 06:00 [entrez]
PHST- 2013/01/22 06:00 [pubmed]
PHST- 2013/08/21 06:00 [medline]
AID - S1047951112001989 [pii]
AID - 10.1017/S1047951112001989 [doi]
PST - ppublish
SO  - Cardiol Young. 2012 Dec;22(6):787-95. doi: 10.1017/S1047951112001989.


PMID- 23331602
OWN - NLM
STAT- MEDLINE
DCOM- 20130820
LR  - 20130121
IS  - 1467-1107 (Electronic)
IS  - 1047-9511 (Linking)
VI  - 22
IP  - 6
DP  - 2012 Dec
TI  - Ethical considerations for post-cardiotomy extracorporeal membrane oxygenation.
PG  - 780-6
LID - 10.1017/S1047951112001540 [doi]
AB  - Significant advances have been made in extracorporeal life support, which has
      resulted in the increased use of post-cardiotomy extracorporeal membrane
      oxygenation. Retrospective studies have contributed to the ongoing evolution of
      selection criteria for post-cardiotomy extracorporeal membrane oxygenation.
      Current indications include failure to wean from cardiopulmonary bypass,
      haemodynamic collapse, pulmonary hypertension, post-repair of hypoplastic left
      heart syndrome, or need for bridge to transplantation. Short- and mid-term
      results are improving. Ethical concerns still attend the process, however. Moral 
      risks related to post-cardiotomy extracorporeal membrane oxygenation may be
      encountered before, during, and after the open heart procedure. At each stage of 
      the decision-making process, moral risks are encountered by many factors that may
      result in decisions that may be contrary to the best interests of the patient,
      parents, or use of shared societal resources. These moral risks centre around the
      selection process, informed consent, decision making in the operating room, and
      post-operative maintenance of extracorporeal membrane oxygenation. Consideration 
      of such risks is affected by questions of haemodynamic stability, haematologic
      compromise, neurologic status, and family concerns. We conclude that thorough
      understanding of the relevant scientific literature, heightened awareness of
      moral risks, and incorporation of ethical tenets in clinical deliberation will
      guide the clinician to do the right thing.
FAU - Mavroudis, Constantine
AU  - Mavroudis C
AD  - Johns Hopkins Children's Heart Surgery, Florida Hospital for Children, Orlando,
      Florida 32804, USA. Constantine.Mavroudis.MD@flhosp.org
FAU - Mavroudis, Constantine D
AU  - Mavroudis CD
FAU - Green, Jeanette
AU  - Green J
FAU - Sade, Robert M
AU  - Sade RM
FAU - Jacobs, Jeffrey P
AU  - Jacobs JP
FAU - Kodish, Eric
AU  - Kodish E
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Cardiol Young
JT  - Cardiology in the young
JID - 9200019
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Extracorporeal Membrane Oxygenation/*ethics
MH  - Heart Defects, Congenital/*surgery
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Morals
MH  - Patient Selection
MH  - Postoperative Period
MH  - Risk
EDAT- 2013/01/22 06:00
MHDA- 2013/08/21 06:00
CRDT- 2013/01/22 06:00
PHST- 2013/01/22 06:00 [entrez]
PHST- 2013/01/22 06:00 [pubmed]
PHST- 2013/08/21 06:00 [medline]
AID - S1047951112001540 [pii]
AID - 10.1017/S1047951112001540 [doi]
PST - ppublish
SO  - Cardiol Young. 2012 Dec;22(6):780-6. doi: 10.1017/S1047951112001540.


PMID- 23330446
OWN - NLM
STAT- MEDLINE
DCOM- 20130207
LR  - 20130422
IS  - 0729-2759 (Print)
IS  - 0729-2759 (Linking)
VI  - 20
IP  - 3
DP  - 2012 Nov
TI  - Analysis of the ethical issues in the breastfeeding and bedsharing debate.
PG  - 7-17
AB  - Recommendations advising against mothers and their infants sharing a bed during
      sleep (bedsharing) have sparked heated debate in recent years, the effects of
      which are that bedsharing is now most often only considered in the polarised
      contexts of being either 'the norm' or 'inherently unsafe'. This has resulted in 
      significant tensions between supporters of bedsharing and public health bodies
      who seek to eliminate the risks associated with SIDS. This paper considers the
      issues surrounding this debate by examining the evidence associated with
      bedsharing, SIDS and breastfeeding. This is undertaken using Baum's six-step
      framework for analysing potential ethical tensions in public health policy, which
      includes the principles of utility, evidence base and effectiveness of action,
      fairness, accountability, costs and burdens, and community acceptance. This
      framework has allowed us to examine the competing principles involved in the
      bedsharing and breastfeeding debate, and arrive at a position constructed using
      ethical considerations.
FAU - Fetherston, Catherine M
AU  - Fetherston CM
AD  - School of Nursing and Midwifery at Murdoch University.
      C.Fetherston@murdoch.edu.au [corrected]
FAU - Leach, J Shaughn
AU  - Leach JS
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Breastfeed Rev
JT  - Breastfeeding review : professional publication of the Nursing Mothers'
      Association of Australia
JID - 9616903
CIN - Breastfeed Rev. 2013 Mar;21(1):38. PMID: 23600326
EIN - Breastfeed Rev. 2013 Mar;21(1):20
MH  - *Beds
MH  - Breast Feeding/*ethics/methods
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Infant
MH  - Infant Care/*ethics/methods
MH  - Maternal Behavior
MH  - *Mother-Child Relations
MH  - Mothers
MH  - Patient Education as Topic
MH  - Postnatal Care/methods
MH  - Sudden Infant Death/*prevention & control
EDAT- 2013/01/22 06:00
MHDA- 2013/02/08 06:00
CRDT- 2013/01/22 06:00
PHST- 2013/01/22 06:00 [entrez]
PHST- 2013/01/22 06:00 [pubmed]
PHST- 2013/02/08 06:00 [medline]
PST - ppublish
SO  - Breastfeed Rev. 2012 Nov;20(3):7-17.


PMID- 23328416
OWN - NLM
STAT- MEDLINE
DCOM- 20131125
LR  - 20130118
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 92
IP  - 44
DP  - 2012 Nov 27
TI  - [Life ethics ruled by law].
PG  - 3097-9
FAU - Zhou, Xin
AU  - Zhou X
AD  - znzfzx@yahoo.com.cn
LA  - chi
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
SB  - IM
MH  - *Bioethical Issues
MH  - *Ethics, Medical
MH  - Humans
EDAT- 2013/01/19 06:00
MHDA- 2013/12/16 06:00
CRDT- 2013/01/19 06:00
PHST- 2013/01/19 06:00 [entrez]
PHST- 2013/01/19 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2012 Nov 27;92(44):3097-9.


PMID- 23328380
OWN - NLM
STAT- MEDLINE
DCOM- 20131223
LR  - 20130118
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 92
IP  - 43
DP  - 2012 Nov 20
TI  - [Effects of different nasotracheal intubations in obstructive sleep apnea
      hypopnea syndrome patients with uvulopalatopharyngoplasty].
PG  - 3067-71
AB  - OBJECTIVE: To explore the safe and effective way of nasotracheal intubations in
      obstructive sleep apnea hypopnea syndrome patients with
      uvulopalatopharyngoplasty. METHODS: Upon the approval of the Ethics Committee at 
      Second Affiliated Hospital of Fujian Medical University, from August 2008 to
      November 2011, 90 sleep apnea hypopnea syndrome patients were randomly divided
      into 3 groups (n=30 each): GlideScope (G), fiberoptic bronchoscope (F) and
      combination of Glidescope with fiberoptic bronchoscope (G+F). The parameters of
      tracheal intubation time, placement of endotracheal intubation, tracheal injury
      and complications were recorded. Also systolic blood pressure (SBP), diastolic
      blood pressure (DBP), mean arterial pressure (MAP) and heart rate (HR) were
      recorded at post-induction, the moment of tracheal intubation and post-intubation
      1, 3, 5 min. Rate pressure product (RPP) was calculated at all time points as the
      product of heart rate and SBP during observation. RESULTS: All of them underwent 
      successful endotracheal intubation. There were 24 successful cases of intubation 
      during the first attempt in Group G with a success rate of 80%; 27 patients
      successful during the first attempt in group F with a success rate of 90%; all in
      group G+F successful during the first attempt with a success rate of 100%. The
      rates were significantly different in 3 groups (P<0.05). Groups G and F patients 
      with failed intubation during the first attempt were of Mallampati III/IV. After 
      induction, SBP, DBP, MAP and RPP were lower in 3 groups (P<0.05) while HR change 
      was not obvious. Compared with the after induction, the moment of tracheal
      intubation and after intubation 1 min, 3 groups of patients with SBP, DBP, MAP,
      HR and RPP increased (P<0.05). Groups F and G+F after intubation in intubated
      patients and 1 min of SBP, DBP, MAP, HR, RPP were higher than G group (P<0.05).
      No difference existed between groups F and G+F. Three groups showed no serious
      tracheal injury, laryngeal edema, hoarseness or other complications. CONCLUSION: 
      During nasotracheal intubation for Mallampati I/II patients, GlideScope offers
      better overall glottic views. For those of Mallampati III and IV, the combination
      of Glidescope with fiberoptic bronchoscope may achieve a higher success rate and 
      shorter intubation time than the latter alone.
FAU - Liu, Wei-feng
AU  - Liu WF
AD  - Department of Anesthesiology, Second Affiliated Hospital, Fujian Medical
      University, Quanzhou 362000, China.
FAU - He, He-pan
AU  - He HP
FAU - Xie, Wen-xi
AU  - Xie WX
FAU - Weng, Pei-qing
AU  - Weng PQ
FAU - Li, Shi-yang
AU  - Li SY
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
SB  - IM
MH  - Adult
MH  - Bronchoscopy
MH  - Female
MH  - Humans
MH  - Intubation, Intratracheal/*methods
MH  - Laryngoscopes
MH  - Male
MH  - Middle Aged
MH  - Nose/surgery
MH  - Pharynx/surgery
MH  - Sleep Apnea, Obstructive/*surgery
EDAT- 2013/01/19 06:00
MHDA- 2013/12/24 06:00
CRDT- 2013/01/19 06:00
PHST- 2013/01/19 06:00 [entrez]
PHST- 2013/01/19 06:00 [pubmed]
PHST- 2013/12/24 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2012 Nov 20;92(43):3067-71.


PMID- 23327773
OWN - NLM
STAT- MEDLINE
DCOM- 20160422
LR  - 20181202
IS  - 2223-6279 (Electronic)
IS  - 0379-8577 (Linking)
VI  - 35
IP  - 1
DP  - 2012 Oct 12
TI  - Perceptions of pregnant teenagers with regard to the antenatal care clinic
      environment.
PG  - 43
LID - 10.4102/curationis.v35i1.43 [doi]
AB  - Pregnancy in teenagers seems to be a challenge that might contribute to a
      struggle to fulfil the objectives of the Millennium Development Goals directly
      related to women's reproductive health and neonatal care. The challenge becomes
      worse as midwives and nurses find it difficult to fully supervise all these
      pregnancies, because teenagers stay away or default from clinic attendance. The
      purpose of the study was to explore and describe the perceptions of pregnant
      teenagers of the antenatal care (ANC) clinic environment and to recommend
      guidelines to midwifery operational managers for strategies to create
      teenager-friendly ANC clinic environments. The study applied a qualitative
      research design with explorative, descriptive and contextual research approaches.
      The ethical principles that guided this study were respect for the person,
      beneficence and justice. Semi-structured interviews utilising a predetermined
      interview schedule with a central open-ended question to address the study
      objectives were used. Data were collected from pregnant teenagers attending ANC
      clinics in Nelson Mandela Metropolitan Municipality. Participants were unanimous 
      in that they perceived the clinic environment as causing discomfort to them.
      Different reasons attributed to this experience were related to their young age. 
      The age difference between themselves and other women attending the clinic made
      participants perceive themselves as inferior and as being treated as such at the 
      clinic. They found this embarrassing and recommended having their own waiting
      area and additional midwives at the clinic so that they would not be subjected to
      humiliating scrutiny and disapproval from older pregnant women. Pregnant
      teenagers' recall of their experiences of the ANC clinic environment suggests
      that they perceive themselves as not being adequately cared for, as judged, and
      as forced to be in an environment that is insensitive to their needs. As a result
      some of their peers stayed away from the clinic and at times they contemplated
      the same action. A well-managed ANC clinic environment which has midwives who are
      empowered with the necessary skills in terms of dealing with the needs of youth
      has been requested by the pregnant teenagers.
FAU - James, Sindiwe
AU  - James S
AD  - Department of Nursing Science, Nelson Mandela Metropolitan University, South
      Africa. Sindiwe.james@nmmu.ac.za
FAU - Rall, Nadine
AU  - Rall N
FAU - Strumpher, Juanita
AU  - Strumpher J
LA  - eng
PT  - Journal Article
DEP - 20121012
PL  - South Africa
TA  - Curationis
JT  - Curationis
JID - 7901092
MH  - Adolescent
MH  - Ambulatory Care Facilities
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Midwifery
MH  - Pregnancy
MH  - *Pregnant Women
MH  - *Prenatal Care
MH  - Qualitative Research
EDAT- 2013/01/19 06:00
MHDA- 2016/04/23 06:00
CRDT- 2013/01/19 06:00
PHST- 2011/08/15 00:00 [received]
PHST- 2012/08/07 00:00 [accepted]
PHST- 2012/03/12 00:00 [revised]
PHST- 2013/01/19 06:00 [entrez]
PHST- 2013/01/19 06:00 [pubmed]
PHST- 2016/04/23 06:00 [medline]
AID - 10.4102/curationis.v35i1.43 [doi]
PST - epublish
SO  - Curationis. 2012 Oct 12;35(1):43. doi: 10.4102/curationis.v35i1.43.


PMID- 23327768
OWN - NLM
STAT- MEDLINE
DCOM- 20160422
LR  - 20220409
IS  - 2223-6279 (Electronic)
IS  - 0379-8577 (Linking)
VI  - 35
IP  - 1
DP  - 2012 Jul 11
TI  - Factors contributing to teenage pregnancy in the Capricorn district of the
      Limpopo Province.
PG  - 19
LID - 10.4102/curationis.v35i1.19 [doi]
AB  - Teenage pregnancy refers to pregnancy of a woman of less than 19 years. It is
      found commonly amongst young people who have been disadvantaged and have poor
      expectations with regard to either their education or job market. Adolescents may
      lack knowledge of access to conventional methods of preventing pregnancy, as they
      may be afraid to seek such information. The study purpose was to identify factors
      contributing to teenage pregnancy in one village in the Capricorn District of the
      Limpopo Province. A quantitative descriptive research approach was chosen.
      Population consisted of all pregnant teenagers attending antenatal care during
      June to August 2007 at one clinic in the Capricorn District of the Limpopo
      Province. Simple random probability sampling was used to include 100 pregnant
      teenagers who satisfied the inclusion criteria. Data were collected through
      structured self-administered questionnaires. Descriptive statistical data
      analysis was used. Ethical considerations were ensured. Findings were classified 
      as demographic data where 24% of the respondents were aged between 15-16 years
      and 76% were aged between 17-19 years. Findings further revealed that 60% of the 
      respondents started to engage in sex at 13-15 years; 48% of the teenagers'
      partners were 21 years and above, 44% depended on a single parents' income; 20%
      father's income, 16% received a social grant and 8% lived on the pension fund of 
      the grandparents. Pregnancy prevention strategies were recommended based on the
      results. The strategies focused on reproductive health services, male involvement
      and adult-teenager communication programmes.
FAU - Mothiba, Tebogo M
AU  - Mothiba TM
AD  - Department of Nursing, University of Limpopo (Turfloop campus), South Africa.
      mariatm@ul.ac.za
FAU - Maputle, Maria S
AU  - Maputle MS
LA  - eng
PT  - Journal Article
DEP - 20120711
PL  - South Africa
TA  - Curationis
JT  - Curationis
JID - 7901092
MH  - Adolescent
MH  - Fathers
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Infant Care
MH  - Pregnancy
MH  - *Pregnancy in Adolescence
MH  - *Prenatal Care
MH  - Sex Education
MH  - Surveys and Questionnaires
EDAT- 2013/01/19 06:00
MHDA- 2016/04/23 06:00
CRDT- 2013/01/19 06:00
PHST- 2011/07/18 00:00 [received]
PHST- 2012/04/17 00:00 [accepted]
PHST- 2012/05/16 00:00 [revised]
PHST- 2013/01/19 06:00 [entrez]
PHST- 2013/01/19 06:00 [pubmed]
PHST- 2016/04/23 06:00 [medline]
AID - 10.4102/curationis.v35i1.19 [doi]
PST - epublish
SO  - Curationis. 2012 Jul 11;35(1):19. doi: 10.4102/curationis.v35i1.19.


PMID- 23327765
OWN - NLM
STAT- MEDLINE
DCOM- 20160422
LR  - 20220409
IS  - 2223-6279 (Electronic)
IS  - 0379-8577 (Linking)
VI  - 35
IP  - 1
DP  - 2012 Jun 20
TI  - The status of academic integrity amongst nursing students at a nursing education 
      institution in the Western Cape.
PG  - 27
LID - 10.4102/curationis.v35i1.27 [doi]
AB  - Honesty is regarded as a basic ethical value in all educational programmes, and
      academic integrity is of undisputed importance in educational environments. The
      literature reviewed revealed that academic dishonesty is wide-ranging and also
      encountered in the nursing education environment. This phenomenon is of concern
      to the nursing fraternity because of the proven positive correlation between
      unethical academic practices and future unethical professional behaviour. Limited
      research data regarding academic dishonesty at nursing education institutions in 
      South Africa and this correlation motivated the present study. The purpose was to
      examine the status of academic integrity amongst nursing students at a nursing
      education institution in the Western Cape. Formulated objectives guided
      investigation of several variables which impact upon academic integrity, for
      example the incidence of and student perceptions around academic dishonesty. A
      quantitative, descriptive survey design was used, with a self-reported
      questionnaire (based on literature review and study objectives) designed to
      obtain information about academic dishonesty. Provision was also made for
      qualitative input from the respondents by including three open-ended questions.
      It was found that academic dishonesty was a reality at the nursing education
      institution where this study was done. Cheating associated with plagiarism and
      assignments was identified as the main problem area. An unacceptably high level
      of dishonesty in completion of practical records was also an area of concern. The
      main recommendations are development and implementation of a code of honour and
      implementation of comprehensive academic integrity policies at the nursing
      education institution, with practical measures aimed at combating cheating in
      tests and examinations.
FAU - Theart, Cecilia J
AU  - Theart CJ
AD  - Faculty of Health Sciences, Stellenbosch University, South Africa.
      cjtheart@pgwc.gov.za
FAU - Smit, Ilze
AU  - Smit I
LA  - eng
PT  - Journal Article
DEP - 20120620
PL  - South Africa
TA  - Curationis
JT  - Curationis
JID - 7901092
MH  - Attitude of Health Personnel
MH  - Deception
MH  - *Education, Nursing
MH  - Education, Nursing, Baccalaureate
MH  - Humans
MH  - Morals
MH  - Plagiarism
MH  - *Students, Nursing
MH  - Surveys and Questionnaires
EDAT- 2013/01/19 06:00
MHDA- 2016/04/23 06:00
CRDT- 2013/01/19 06:00
PHST- 2011/07/28 00:00 [received]
PHST- 2011/12/12 00:00 [accepted]
PHST- 2011/12/06 00:00 [revised]
PHST- 2013/01/19 06:00 [entrez]
PHST- 2013/01/19 06:00 [pubmed]
PHST- 2016/04/23 06:00 [medline]
AID - 10.4102/curationis.v35i1.27 [doi]
PST - epublish
SO  - Curationis. 2012 Jun 20;35(1):27. doi: 10.4102/curationis.v35i1.27.


PMID- 23327762
OWN - NLM
STAT- MEDLINE
DCOM- 20160422
LR  - 20181202
IS  - 2223-6279 (Electronic)
IS  - 0379-8577 (Linking)
VI  - 35
IP  - 1
DP  - 2012 May 18
TI  - Experiences of family members caring for tuberculosis patients at home at Vhembe 
      district of the Limpopo Province.
PG  - 54
LID - 10.4102/curationis.v35i1.54 [doi]
AB  - Tuberculosis (TB) is a potentially serious infectious disease which enters the
      body by inhalation and usually affects the lungs. TB is ranked amongst the
      leading infectious diseases worldwide, and in South Africa (SA) it has become an 
      epidemic, because of its high prevalence. There are multiple factors that were
      found to attribute to the existence and spread of this disease. The purpose of
      this study was to explore and describe experiences of family members caring for
      TB patients at home, in the Vhembe District of the Limpopo Province. The study
      was qualitative, explorative, descriptive, phenomenological and contextual in
      nature. The population group selected for the study all comprised of family
      members caring for tuberculosis patients at home in Tshifulanani village. A
      purposive sampling method was applied in the study. Data were collected through
      semi-structured interviews guided by three questions. Tech's eight steps of data 
      analysis were followed. Measures to ensure trustworthiness and ethical issues
      were observed. The results of the study revealed that family members experienced 
      difficulties when they care for TB patients at home. These difficulties included 
      providing food, attending to hygiene needs, the lack of equipment, financial
      constraints as well as physical and psychological exhaustion. Recommendations
      were made concerning the provision food, attending to hygiene needs, assisting in
      the administration of medication, nursing practice and policy making.
FAU - Sukumani, Joyce T
AU  - Sukumani JT
AD  - Department of Advanced Nursing, University of Venda, South Africa.
FAU - Lebese, Rachel T
AU  - Lebese RT
FAU - Khoza, Lunic B
AU  - Khoza LB
FAU - Risenga, Patrone R
AU  - Risenga PR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120518
PL  - South Africa
TA  - Curationis
JT  - Curationis
JID - 7901092
MH  - Empathy
MH  - *Family
MH  - Humans
MH  - Nursing Methodology Research
MH  - Policy Making
MH  - Qualitative Research
MH  - South Africa/epidemiology
MH  - *Tuberculosis
EDAT- 2013/01/19 06:00
MHDA- 2016/04/23 06:00
CRDT- 2013/01/19 06:00
PHST- 2011/09/02 00:00 [received]
PHST- 2012/02/28 00:00 [accepted]
PHST- 2012/01/17 00:00 [revised]
PHST- 2013/01/19 06:00 [entrez]
PHST- 2013/01/19 06:00 [pubmed]
PHST- 2016/04/23 06:00 [medline]
AID - 10.4102/curationis.v35i1.54 [doi]
PST - epublish
SO  - Curationis. 2012 May 18;35(1):54. doi: 10.4102/curationis.v35i1.54.


PMID- 23327761
OWN - NLM
STAT- MEDLINE
DCOM- 20160422
LR  - 20220316
IS  - 2223-6279 (Electronic)
IS  - 0379-8577 (Linking)
VI  - 35
IP  - 1
DP  - 2012 May 9
TI  - Barriers to quality patient care in rural district hospitals.
PG  - 36
LID - 10.4102/curationis.v35i1.36 [doi]
AB  - Currently barriers exist in delivering quality health care. This study aimed to
      investigate such barriers in the eight rural district hospitals of the West Coast
      Winelands Region, three type A and five type B hospitals. A quantitative
      descriptive design was applied which included the total population of nursing
      staff (n = 340) working at the time of data collection. A self-administered
      questionnaire was distributed with a response rate of 82%. Reliability of the
      instrument was verified using the Cronbach alpha coefficient and a pilot study.
      The validity, specifically construct and content validity, were assured by means 
      of an extensive literature review, pilot study and use of experts. Ethics
      approval was obtained from the relevant stakeholders. Results showed that 272
      participants (97%) disagreed that provision of staff was adequate, with staff
      above 40 years of age more likely to disagree (p = <0.01). A statistically
      significant association was shown between availability of doctors and staff not
      being able to cope with emergencies (p = <0.01). Most participants (n =212; 76%) 
      indicated that they were not receiving continuing education, with the registered 
      nurses more likely to disagree (chi(2) test, p = 0.02). Participants in both
      hospital types A (n = 131; 82%) and B (n = 108; 91%) also disagreed that
      provision of equipment and consumables was adequate. The research showed that
      inadequacies relating to human resources, professional development, consumables
      and equipment influenced the quality of patient care. Urgent attention should be 
      given to the problems identified to ensure quality of patient care in rural
      hospitals.
FAU - Eygelaar, Johanna E
AU  - Eygelaar JE
AD  - Faculty of Health Sciences, Stellenbosch University, South Africa.
FAU - Stellenberg, Ethelwynn L
AU  - Stellenberg EL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120509
PL  - South Africa
TA  - Curationis
JT  - Curationis
JID - 7901092
MH  - Attitude of Health Personnel
MH  - *Hospitals, District
MH  - Humans
MH  - Nursing Staff, Hospital/education
MH  - Patient Care
MH  - Pilot Projects
MH  - *Reproducibility of Results
MH  - Surveys and Questionnaires
EDAT- 2013/01/19 06:00
MHDA- 2016/04/23 06:00
CRDT- 2013/01/19 06:00
PHST- 2011/08/10 00:00 [received]
PHST- 2012/02/18 00:00 [accepted]
PHST- 2013/01/19 06:00 [entrez]
PHST- 2013/01/19 06:00 [pubmed]
PHST- 2016/04/23 06:00 [medline]
AID - 10.4102/curationis.v35i1.36 [doi]
PST - epublish
SO  - Curationis. 2012 May 9;35(1):36. doi: 10.4102/curationis.v35i1.36.


PMID- 23327055
OWN - NLM
STAT- MEDLINE
DCOM- 20130416
LR  - 20200929
IS  - 0392-2936 (Print)
IS  - 0392-2936 (Linking)
VI  - 33
IP  - 6
DP  - 2012
TI  - Prognostic factors determining recurrence in early-stage endometrial cancer.
PG  - 610-4
AB  - OBJECTIVE: This study aimed to determine the clinically important prognostic
      factors for loco-regional or distant recurrence in early-stage endometrial
      cancer. MATERIALS AND METHODS: This study complied with the Declaration of
      Helsinki, and the local ethics committee approved the study. Cases who underwent 
      primary surgery of early-stage endometrial cancer at the Institution from 2000 to
      2012 were reviewed retrospectively. Patients who did not detect recurrence were
      classified as group 1 (n = 200); those who detected recurrence were classified as
      group 2 (n = 23). Clinically prognostic factors were evaluated by univariate
      analyses. RESULTS: The average age for group 2 (LUSI) was 63.8 years (p =
      0.0001). Patients with grade 3 histology were all detected within group 2 (p =
      0.0001). Endometrioid adenocarcinoma displaying squamous differentiation was
      found with a rate of 58.3% in group 2 (p = 0.0001). Lower uterine segment
      involvement (LUSI) and lymphovascular space invasion (LVSI) rates were 86.9% in
      group 2 (p = 0.0001). The rate of tumor size > 2 cm was 56.6% in group 2 (p =
      0.0001). The median depth of myometrial invasion (DMI) was 5.1 mm (p = 0.034) and
      the average in myometrial thickness was 14.5 mm in group II (p = 0.0001). The
      percentage of myometrial invasion was 35.8% in Group II (p = 0.0001). Tumor
      free-distance was 9.4 mm in group II (p = 0.0001). CONCLUSION: Age and
      clinicopathological parameters of the tumours are significant predictors for
      recurrence in early-stage endometrial cancer.
FAU - Misirlioglu, S
AU  - Misirlioglu S
AD  - Department of Obstetrics and Gynecology, Faculty of Medicine, Cukurova
      University, Adana, Turkey.
FAU - Guzel, A B
AU  - Guzel AB
FAU - Gulec, U K
AU  - Gulec UK
FAU - Gumurdulu, D
AU  - Gumurdulu D
FAU - Vardar, M A
AU  - Vardar MA
LA  - eng
PT  - Journal Article
PL  - Singapore
TA  - Eur J Gynaecol Oncol
JT  - European journal of gynaecological oncology
JID - 8100357
SB  - IM
MH  - Adult
MH  - Aged
MH  - Endometrial Neoplasms/*pathology
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Neoplasm Invasiveness
MH  - Neoplasm Recurrence, Local/*etiology
MH  - Neoplasm Staging
MH  - Prognosis
EDAT- 2013/01/19 06:00
MHDA- 2013/04/17 06:00
CRDT- 2013/01/19 06:00
PHST- 2013/01/19 06:00 [entrez]
PHST- 2013/01/19 06:00 [pubmed]
PHST- 2013/04/17 06:00 [medline]
PST - ppublish
SO  - Eur J Gynaecol Oncol. 2012;33(6):610-4.


PMID- 23327035
OWN - NLM
STAT- MEDLINE
DCOM- 20130218
LR  - 20181202
IS  - 0544-0440 (Print)
IS  - 0544-0440 (Linking)
VI  - 21
IP  - 4
DP  - 2012 Feb
TI  - The effect of dexmedetomidine on bispectral index monitoring in children.
PG  - 613-8
AB  - The primary aim of this study was to test whether dexmedetomidine administration 
      based on the bispectral index (BIS) monitoring caused a reduction in consumption 
      of sevoflurane. Following Institutional Ethic Committee approval and written
      informed consent from all parents, fifty-four children undergoing sevoflurane
      anaesthesia randomly allocated to receive either dexmedetomidine (Group D) or
      saline (Group S). The anaesthesia was induced with 8% sevoflurane in nitrous
      oxide/oxygen in all children. Following anaesthesia induction, Group D (n=27)
      children received a loading dose of dexmedetomidine 1 microgkg(-1) IV over ten
      minutes, followed by a continuous infusion at a rate of 0.5 microgkg(-1) hr(-1)
      throughout the surgery. Group S (n = 27) children received same volume of saline 
      infusion due to obtained blindness. Systolic blood pressure (SBP), diastolic
      blood pressure (DBP), heart rate (HR), body temperature and peripheral oxygen
      saturation (SpO2), end-tidal concentrations of oxygen, carbon dioxide (ETCO2),
      and sevoflurane (ETsevo) were monitorized. Bispectral index numbers and ETsevo
      concentrations were recorded at 2 min before incision, 2 min after incision, at
      the end of surgery and before the termination of anaesthesia, and finally
      immediately after wake-up from anaesthesia (Final BIS number). BIS number was
      found significantly lower in group D at before incision, after incision and at
      the end of surgery than in group S (p = 0.000, 0.001, 0.007). End tidal
      sevoflurane concentrations were significantly higher in group S at before
      incision, after incision and at the end of surgery than in group D (p < 0.000 to 
      p < 0.001). Final BIS number and sevoflurane concentrations were similar and
      there were no significant difference between the groups. It was concluded that
      intravenous (IV) dexmedetomidine infusion at a rate of 0.5 microgkg(-1) hr(-1)
      during sevoflurane anaesthesia significantly reduces end-tidal sevoflurane
      concentration and BIS number in children undergoing minor surgical interventions.
FAU - Ozcengiz, Dilek
AU  - Ozcengiz D
AD  - Cukurova University, Faculty of Medicine, Department of Anesthesiology
      Adana/Turkey. dilekozcengiz@gmail.com
FAU - Unlugenc, Hakki
AU  - Unlugenc H
FAU - Gunes, Yasemin
AU  - Gunes Y
FAU - Karacaer, Feride
AU  - Karacaer F
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Lebanon
TA  - Middle East J Anaesthesiol
JT  - Middle East journal of anaesthesiology
JID - 8604187
RN  - 0 (Anesthetics, Inhalation)
RN  - 0 (Hypnotics and Sedatives)
RN  - 0 (Methyl Ethers)
RN  - 38LVP0K73A (Sevoflurane)
RN  - 67VB76HONO (Dexmedetomidine)
RN  - K50XQU1029 (Nitrous Oxide)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Anesthetics, Inhalation/*administration & dosage
MH  - Blood Pressure
MH  - Body Temperature
MH  - Child
MH  - Child, Preschool
MH  - Consciousness Monitors
MH  - Dexmedetomidine/administration & dosage/*pharmacology
MH  - Double-Blind Method
MH  - Female
MH  - Heart Rate
MH  - Humans
MH  - Hypnotics and Sedatives/administration & dosage/*pharmacology
MH  - Infusions, Intravenous
MH  - Male
MH  - Methyl Ethers/*administration & dosage
MH  - Monitoring, Intraoperative/methods
MH  - Nitrous Oxide/administration & dosage
MH  - Oxygen/administration & dosage/metabolism
MH  - Prospective Studies
MH  - Sevoflurane
EDAT- 2013/01/19 06:00
MHDA- 2013/02/19 06:00
CRDT- 2013/01/19 06:00
PHST- 2013/01/19 06:00 [entrez]
PHST- 2013/01/19 06:00 [pubmed]
PHST- 2013/02/19 06:00 [medline]
PST - ppublish
SO  - Middle East J Anaesthesiol. 2012 Feb;21(4):613-8.


PMID- 23327030
OWN - NLM
STAT- MEDLINE
DCOM- 20130218
LR  - 20181202
IS  - 0544-0440 (Print)
IS  - 0544-0440 (Linking)
VI  - 21
IP  - 4
DP  - 2012 Feb
TI  - Comparison of the anesthetic effects of intrathecal levobupivacaine + fentanyl
      and bupivacaine + fentanyl during caesarean section.
PG  - 577-82
AB  - BACKGROUND: Regional anesthesia techniques are increasingly preferred for
      caesarean section. The aim of the present study was to compare the anesthetic
      effects of levobupivacaine + fentanyl and bupivacaine + fentanyl on the mother
      and newborn during elective caesarean section under spinal anesthesia. METHODS:
      In this prospective study, 50 gravidas, who were scheduled for cesarean section
      were enrolled after Ethics Committee approval had been obtained. The patients
      were randomized into one of the following two groups: bupivacaine + fentanyl
      group (group B; n = 25), 7.5 mg of 0.5% bupivacaine + 15 microg fentanyl
      intrathecally; levobupivacaine + fentanyl group (group L; n = 25), 7.5 mg of 0.5%
      levobupivacaine + 15 microg fentanyl intrathecally. The patients were immediately
      placed in supine position with 20-30 degrees head up-tilt. The level of sensory
      and motor blocks were evaluated by pin-prick test and Bromage scale,
      respectively. RESULTS: The time to sensory block at the T4 dermatome was shorter 
      in group B (group B, 4.8 min; group L, 6.0 min; p < 0.05). The time to maximum
      motor block was also shorter in group B (group B, 3.4 min; group L, 4.7 min; p < 
      0.05). The duration of analgesia was longer in group L compared to group B (group
      B, 102 min; group L, 118 min; p < 0.05). CONCLUSIONS: Time to sensory and maximum
      motor block was shorter in the bupivacaine + fentanyl group. On the other hand, a
      longer duration of analgesia was achieved in the levobupivacaine + fentanyl
      group. Although levobupivacaine is a novel drug, it is a good alternative for
      bupivacaine.
FAU - Turkmen, Aygen
AU  - Turkmen A
AD  - Okmeydani Training and Research Hospital, Anesthesiology and Reanimation Clinic, 
      Istanbul, Turkey. aygenturkmen@hotmail.com
FAU - Moralar, Dondu Genc
AU  - Moralar DG
FAU - Ali, Ahmet
AU  - Ali A
FAU - Altan, Aysel
AU  - Altan A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Lebanon
TA  - Middle East J Anaesthesiol
JT  - Middle East journal of anaesthesiology
JID - 8604187
RN  - 0 (Anesthetics, Intravenous)
RN  - 0 (Anesthetics, Local)
RN  - A5H73K9U3W (Levobupivacaine)
RN  - UF599785JZ (Fentanyl)
RN  - Y8335394RO (Bupivacaine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anesthesia, Obstetrical/*methods
MH  - Anesthetics, Intravenous/administration & dosage
MH  - Anesthetics, Local/administration & dosage
MH  - Bupivacaine/administration & dosage/analogs & derivatives
MH  - Cesarean Section/*methods
MH  - Drug Therapy, Combination
MH  - Female
MH  - Fentanyl/*administration & dosage
MH  - Humans
MH  - Infant, Newborn
MH  - Injections, Spinal
MH  - Levobupivacaine
MH  - Pregnancy
MH  - Prospective Studies
MH  - Supine Position
MH  - Time Factors
MH  - Young Adult
EDAT- 2013/01/19 06:00
MHDA- 2013/02/19 06:00
CRDT- 2013/01/19 06:00
PHST- 2013/01/19 06:00 [entrez]
PHST- 2013/01/19 06:00 [pubmed]
PHST- 2013/02/19 06:00 [medline]
PST - ppublish
SO  - Middle East J Anaesthesiol. 2012 Feb;21(4):577-82.


PMID- 23326790
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130118
LR  - 20211021
IS  - 2277-9175 (Print)
IS  - 2277-9175 (Linking)
VI  - 1
DP  - 2012
TI  - Epidermal growth factor receptor expression in mice skin upon ultraviolet B
      exposure - Seborrheic Keratosis as a coincidental and unique finding.
PG  - 59
LID - 10.4103/2277-9175.100178 [doi]
AB  - BACKGROUND: Ultraviolet B (UVB) is the most damaging component of sunlight. It
      rapidly activates the epidermal growth factor receptor (EGFR) and generates
      reactive oxygen species (ROS) in excessive quantities that quickly overwhelm
      tissue antioxidants. SETTING AND DESIGN: To demonstrate the effects of UVB
      radiation on EGFR expression in mice skin and to evaluate the role of
      antioxidants in the exposed group. MATERIALS AND METHODS: After obtaining the
      approval of the ethical committee, forty mice from BALB/c strain were used in
      this experiment and were allocated into 3 groups; 10 (control group); 15
      (exposure group); and 15 (exposed and treated with antioxidants). Antioxidants
      were administered through subcutaneous injection. Skin biopsies from all groups
      were stained with EGFR antibodies. Total antioxidant status (TAS) was evaluated
      in all groups. STATISTICAL ANALYSIS: The data obtained were analyzed using ANOVA,
      Duncan's test, and Pearson's Correlation. RESULTS: The highest EGFR expression in
      exposure group was of score 3(+) (53%). The highest EGFR expression in treatment 
      group was score 0 (40%). Apoptotic bodies and dermal mast cells increased in
      exposure group while decreased in treatment group. The mean values for TAS were
      measured for each group; control group = 1.2 mmol/l; exposure group = 0.87
      mmol/l; treatment group =1.3 mmol/l. CONCLUSIONS: UVB led to Seborrheic Keratosis
      (SK) in mice through enhancement of EGFR expression. Antioxidants effectively
      reduced UVB-induced SK, reduced epidermal changes, apoptotic bodies, and
      decreased dermal mast cells. TAS measurement declined in exposure group, while it
      was within normal range in most treated cases.
FAU - Saeed, Azad K
AU  - Saeed AK
AD  - Department of Pathology, College of Veterinary Medicine, Sulaimani
      University/Kurdistan, Iraq.
FAU - Salmo, Nabil
AU  - Salmo N
LA  - eng
PT  - Journal Article
DEP - 20120828
PL  - India
TA  - Adv Biomed Res
JT  - Advanced biomedical research
JID - 101586897
PMC - PMC3544126
OTO - NOTNLM
OT  - Apoptotic bodies
OT  - Ultraviolet B
OT  - epidermal growth factor receptor
OT  - mast cells
OT  - seborrheic keratosis
OT  - total antioxidant status
EDAT- 2013/01/18 06:00
MHDA- 2013/01/18 06:01
CRDT- 2013/01/18 06:00
PHST- 2012/04/02 00:00 [received]
PHST- 2012/05/08 00:00 [accepted]
PHST- 2013/01/18 06:00 [entrez]
PHST- 2013/01/18 06:00 [pubmed]
PHST- 2013/01/18 06:01 [medline]
AID - 10.4103/2277-9175.100178 [doi]
AID - ABR-1-59 [pii]
PST - ppublish
SO  - Adv Biomed Res. 2012;1:59. doi: 10.4103/2277-9175.100178. Epub 2012 Aug 28.


PMID- 23326680
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130118
LR  - 20220409
IS  - 2090-5491 (Electronic)
IS  - 2090-5483 (Linking)
VI  - 2012
DP  - 2012
TI  - Iranian Nurses' Attitudes and Perception towards Patient Advocacy.
PG  - 645828
LID - 10.5402/2012/645828 [doi]
AB  - Patient advocacy is an inherent component of professional nursing ethics; in
      other words, nurses' enough knowledge would be essential to gain a positive
      attitude towards nursing advocacy. Using a descriptive-analytic design, this
      study aimed to assess the correlation between nurses' perception and attitudes
      towards patient advocacy, amongst 385 nurses in Kerman, Iran; hence, a three-part
      questionnaire was applied: part I, a demographic data sheet, part II, attitude
      measuring instrument, and part III, perception measuring instrument in nursing
      advocacy. The results implied that fairly positive attitudes and perception were 
      found amongst the participants, and nurses' attitudes, in general, were
      positively correlated to their perception toward nursing advocacy. This means
      that with an improvement in perception, the attitude would also improve. In
      addition to our findings, it seems that these nurses needed more advocacy
      educational programs and support from responsible employers.
FAU - Motamed-Jahromi, Mohadeseh
AU  - Motamed-Jahromi M
AD  - Razi School of Nursing and Midwifery, Kerman University of Medical Sciences,
      Kerman 7616913555, Iran.
FAU - Abbaszadeh, Abbas
AU  - Abbaszadeh A
FAU - Borhani, Fariba
AU  - Borhani F
FAU - Zaher, Homa
AU  - Zaher H
LA  - eng
PT  - Journal Article
DEP - 20121230
PL  - Egypt
TA  - ISRN Nurs
JT  - ISRN nursing
JID - 101562314
PMC - PMC3544248
EDAT- 2013/01/18 06:00
MHDA- 2013/01/18 06:01
CRDT- 2013/01/18 06:00
PHST- 2012/11/16 00:00 [received]
PHST- 2012/12/10 00:00 [accepted]
PHST- 2013/01/18 06:00 [entrez]
PHST- 2013/01/18 06:00 [pubmed]
PHST- 2013/01/18 06:01 [medline]
AID - 10.5402/2012/645828 [doi]
PST - ppublish
SO  - ISRN Nurs. 2012;2012:645828. doi: 10.5402/2012/645828. Epub 2012 Dec 30.


PMID- 23326659
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130118
LR  - 20211021
IS  - 2090-147X (Electronic)
IS  - 2090-1461 (Linking)
VI  - 2012
DP  - 2012
TI  - Basic Plastic Surgery Skills Training Program on Inanimate Bench Models during
      Medical Graduation.
PG  - 651863
LID - 10.1155/2012/651863 [doi]
AB  - Due to ethical and medical-legal drawbacks, high costs, and difficulties of
      accessibility that are inherent to the practice of basic surgical skills on
      living patients, fresh human cadaver, and live animals, the search for
      alternative forms of training is needed. In this study, the teaching and learning
      process of basic surgical skills pertinent to plastic surgery during medical
      education on different inanimate bench models as a form of alternative and
      complementary training to the teaching programs already established is proposed.
FAU - Denadai, Rafael
AU  - Denadai R
AD  - Institute of Plastic and Craniofacial Surgery, SOBRAPAR Hospital, Avenue Adolpho 
      Lutz 100, Caixa Postal 6028, 13084-880 Campinas, SP, Brazil ; Division of Plastic
      and Reconstructive Surgery, Department of Surgery, School of Medical Sciences,
      University of Mariotalia (UNIMAR), 17525-902 Mariotalia, SP, Brazil.
FAU - Toledo, Andreia Padilha
AU  - Toledo AP
FAU - Martinhao Souto, Luis Ricardo
AU  - Martinhao Souto LR
LA  - eng
PT  - Journal Article
DEP - 20121230
PL  - United States
TA  - Plast Surg Int
JT  - Plastic surgery international
JID - 101578808
PMC - PMC3544258
EDAT- 2013/01/18 06:00
MHDA- 2013/01/18 06:01
CRDT- 2013/01/18 06:00
PHST- 2012/10/01 00:00 [received]
PHST- 2012/11/12 00:00 [revised]
PHST- 2012/11/19 00:00 [accepted]
PHST- 2013/01/18 06:00 [entrez]
PHST- 2013/01/18 06:00 [pubmed]
PHST- 2013/01/18 06:01 [medline]
AID - 10.1155/2012/651863 [doi]
PST - ppublish
SO  - Plast Surg Int. 2012;2012:651863. doi: 10.1155/2012/651863. Epub 2012 Dec 30.


PMID- 23326098
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130118
LR  - 20211021
IS  - 0976-500X (Print)
IS  - 0976-500X (Linking)
VI  - 3
IP  - 4
DP  - 2012 Oct
TI  - Ethics of expert opinion and the observations of the department-related
      parliamentary standing committee on the CDSCO.
PG  - 297-9
LID - 10.4103/0976-500X.103684 [doi]
FAU - Jesani, Amar
AU  - Jesani A
AD  - Editor, Indian Journal of Medical Ethics (www.ijme.in), Trustee, Anusandhan
      Trust, Mumbai, Maharashtra, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Pharmacol Pharmacother
JT  - Journal of pharmacology & pharmacotherapeutics
JID - 101552113
PMC - PMC3543547
EDAT- 2013/01/18 06:00
MHDA- 2013/01/18 06:01
CRDT- 2013/01/18 06:00
PHST- 2013/01/18 06:00 [entrez]
PHST- 2013/01/18 06:00 [pubmed]
PHST- 2013/01/18 06:01 [medline]
AID - 10.4103/0976-500X.103684 [doi]
AID - JPP-3-297 [pii]
PST - ppublish
SO  - J Pharmacol Pharmacother. 2012 Oct;3(4):297-9. doi: 10.4103/0976-500X.103684.


PMID- 23326011
OWN - NLM
STAT- MEDLINE
DCOM- 20131223
LR  - 20211021
IS  - 1827-675X (Electronic)
IS  - 0392-100X (Linking)
VI  - 32
IP  - 5
DP  - 2012 Oct
TI  - Endoscopic dilatation sinus surgery (FEDS) versus functional endoscopic sinus
      surgery (FESS) for treatment of chronic rhinosinusitis: a pilot study.
PG  - 314-9
AB  - The objective of the present study was to compare the efficacy of functional
      endoscopic dilatation sinus surgery (FEDS) with functional endoscopic sinus
      surgery (FESS) in treatment of chronic rhinosinusitis in patients who failed
      medical therapy. We enrolled 24 patients suffering with chronic rhinosinusitis,
      who failed medical treatment and were proceeding to surgery, in a prospective,
      randomized controlled pilot study carried out between January and December 2008
      following ethical committee approval. All patients completed sino-nasal outcome
      test (SNOT)-20 questionnaires and underwent saccharine test preoperatively and 24
      weeks post operatively. Only trained surgeons performed surgery. The SNOT-20
      questionnaire and saccharine clearance time (SCT) were used to measure outcomes. 
      The SNOT-20 scores for both patient groups showed similar, consistent symptomatic
      improvement compared with baseline measures. SCT was reduced in both groups. No
      significant post-operative complications were recorded in either group. No
      patient in the FEDS group had any bleeding, and all were ready for discharge
      within hours of the procedure. Thus, FEDS is as effective as FESS in treatment of
      chronic rhinosinusitis. It is can be considered an additional tool in endoscopic 
      surgery and has the potential to be undertaken as a day procedure.
FAU - Achar, P
AU  - Achar P
AD  - Wrightington, Wigan & Leigh NHS Foundation Trust, Wigan, UK.
      priya_orl@hotmail.co.uk
FAU - Duvvi, S
AU  - Duvvi S
FAU - Kumar, B N
AU  - Kumar BN
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Italy
TA  - Acta Otorhinolaryngol Ital
JT  - Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di
      otorinolaringologia e chirurgia cervico-facciale
JID - 8213019
SB  - IM
MH  - Adult
MH  - Chronic Disease
MH  - Dilatation
MH  - *Endoscopy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Otorhinolaryngologic Surgical Procedures/methods
MH  - Pilot Projects
MH  - Prospective Studies
MH  - Rhinitis/complications/*surgery
MH  - Sinusitis/complications/*surgery
PMC - PMC3546409
OTO - NOTNLM
OT  - Balloon sinuplasty
OT  - Chronic rhinosinusitis
OT  - FESS
EDAT- 2013/01/18 06:00
MHDA- 2013/12/24 06:00
CRDT- 2013/01/18 06:00
PHST- 2011/09/16 00:00 [received]
PHST- 2012/04/30 00:00 [accepted]
PHST- 2013/01/18 06:00 [entrez]
PHST- 2013/01/18 06:00 [pubmed]
PHST- 2013/12/24 06:00 [medline]
PST - ppublish
SO  - Acta Otorhinolaryngol Ital. 2012 Oct;32(5):314-9.


PMID- 23324788
OWN - NLM
STAT- MEDLINE
DCOM- 20130619
LR  - 20130117
IS  - 1095-9114 (Electronic)
IS  - 0895-3996 (Linking)
VI  - 20
IP  - 4
DP  - 2012
TI  - A study of CT monochromatic imaging for quantitative detecting hemoglobin levels.
PG  - 483-8
LID - 10.3233/XST-2012-00354 [doi]
AB  - PURPOSE: The purpose of this study was to investigate the value of spectral CT
      monoenergetic imaging for detecting hemoglobin levels. MATERIAL AND METHODS:
      Sixty-five hospitalized patients received chest non-contrast CT scan in gemstone 
      spectral imaging (GSI) mode on a GE Discovery CT750 HD. This study was approved
      by the hospital ethics committee and informed consent was signed by every
      patient. Raw data were reconstructed at 1.25 mm and then transferred to a AW4.4
      workstation. The CT value of the ascending aorta at 40 keV approximately 140 keV 
      was measured under GSI viewer of AW4.4. Hemoglobin contents were measured
      biochemically within 24 hrs after CT scan. The SPSS 16.0 software package was
      used to analyze the correlation between the obtained CT value and hemoglobin
      level. RESULTS: At 40 keV approximately 100 keV, the CT value decreased followed 
      by the increase of keV and gradually stabilized at 100 keV approximately 140 keV 
      with an amplitude variation of 10 HU. The CT values measured at 40 keV
      approximately 140 keV were well correlated with hemoglobin levels. The optimal
      correlation was observed at the monoenergetic level of 70 keV (r=0.633, p=0.000).
      The relationship between CT value and hemoglobin content could be expressed as CT
      value=13.015+0.245 x hemoglobin content. At 40 keV approximately 140 keV, there
      is strong linear correlation between the CT value of the ascending aorta and
      hemoglobin content. The optimal linear relationship was observed at 70 keV.
      CONCLUSION: Spectral CT monoenergetic imaging can be applied for quantitative
      determination of hemoglobin content within a specified area of the circulatory
      system.
FAU - Wu, Xingwang
AU  - Wu X
AD  - Department of Radiology, The First Affiliated Hospital of Anhui Medical
      University, Hefei, Anhui, China.
FAU - Wang, Wanqin
AU  - Wang W
FAU - Wang, Le
AU  - Wang L
FAU - Liu, Bin
AU  - Liu B
FAU - Yu, Yongqiang
AU  - Yu Y
FAU - Zhang, Shuai
AU  - Zhang S
FAU - Gao, Na
AU  - Gao N
FAU - Shen, Yun
AU  - Shen Y
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - Netherlands
TA  - J Xray Sci Technol
JT  - Journal of X-ray science and technology
JID - 9000080
RN  - 0 (Hemoglobins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aortography
MH  - Female
MH  - Hemoglobins/*analysis
MH  - Humans
MH  - Image Processing, Computer-Assisted/*methods
MH  - Male
MH  - Middle Aged
MH  - Radiography, Thoracic
MH  - Regional Blood Flow
MH  - Regression Analysis
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2013/01/18 06:00
MHDA- 2013/06/20 06:00
CRDT- 2013/01/18 06:00
PHST- 2013/01/18 06:00 [entrez]
PHST- 2013/01/18 06:00 [pubmed]
PHST- 2013/06/20 06:00 [medline]
AID - A803G42832J681G1 [pii]
AID - 10.3233/XST-2012-00354 [doi]
PST - ppublish
SO  - J Xray Sci Technol. 2012;20(4):483-8. doi: 10.3233/XST-2012-00354.


PMID- 23324206
OWN - NLM
STAT- MEDLINE
DCOM- 20130618
LR  - 20130117
IS  - 1556-2654 (Electronic)
IS  - 1556-2646 (Linking)
VI  - 7
IP  - 5
DP  - 2012 Dec
TI  - Facilitating enrollment in a Cancer Registry through modified consent procedures:
      a pilot study.
PG  - 71-5
LID - 10.1525/jer.2012.7.5.71 [doi]
AB  - Research registries are increasingly important in medical research and are
      essential to the mission of cancer centers. However, designing enrollment and
      data collection procedures that are consistent with ethical norms and regulatory 
      requirements yet are efficient and cost effective is a major challenge. Current
      standard consent forms can be a barrier to enrollment because of their length,
      multiple components, and technical language. We pilot tested an IRB-approved
      registry booklet and simplified one-page, tiered consent form, allowing for
      choice of extent of participation. The booklet was mailed to patients with breast
      cancer as part of their routine information packet prior to the first clinic
      appointment. A research nurse met with 27 patients at initial treatment to review
      the booklet, answer questions, obtain informed consent, and collect quality of
      life data. The consent rate was 78% with 21 patients enrolling in the study.
      Twelve of the 21 patients (57%) did not read the booklet prior to the visit. The 
      9 patients (43%) who had read the booklet prior to arrival found it easy to
      understand. The multi-stage, simplified consent process and data collection were 
      acceptable to these patients and readily integrated into clinical operations. An 
      easy-to-read registry booklet may be an effective guide for discussion, but
      in-person consent procedures and further testing of the approach are required.
FAU - Mazanec, Susan
AU  - Mazanec S
AD  - School of Nursing, Case Western Reserve University, 10900 Euclid Avenue,
      Cleveland, OH44106-4904, USA. susan. mazanec@case.edu
FAU - Daly, Barbara
AU  - Daly B
FAU - Meropol, Neal J
AU  - Meropol NJ
FAU - Step, Mary
AU  - Step M
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - *Biomedical Research/ethics/legislation & jurisprudence
MH  - *Breast Neoplasms
MH  - Comprehension
MH  - *Consent Forms
MH  - Data Collection
MH  - Ethics Committees, Research
MH  - Female
MH  - Humans
MH  - *Informed Consent
MH  - Nurses
MH  - Office Visits
MH  - *Pamphlets
MH  - Patient Selection/*ethics
MH  - Pilot Projects
MH  - Postal Service
MH  - *Registries/ethics
EDAT- 2013/01/18 06:00
MHDA- 2013/06/19 06:00
CRDT- 2013/01/18 06:00
PHST- 2013/01/18 06:00 [entrez]
PHST- 2013/01/18 06:00 [pubmed]
PHST- 2013/06/19 06:00 [medline]
AID - 10.1525/jer.2012.7.5.71 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2012 Dec;7(5):71-5. doi: 10.1525/jer.2012.7.5.71.


PMID- 23324204
OWN - NLM
STAT- MEDLINE
DCOM- 20130618
LR  - 20171116
IS  - 1556-2654 (Electronic)
IS  - 1556-2646 (Linking)
VI  - 7
IP  - 5
DP  - 2012 Dec
TI  - Does the requirement of getting active consent from parents in school-based
      research result in a biased sample? An empirical study.
PG  - 56-62
LID - 10.1525/jer.2012.7.5.56 [doi]
AB  - Active parental consent is a requirement that may threaten the validity of
      including minors in research. This study investigated possible sources of bias
      between the responses of children whose parents actively consented to their
      participation in a school-based survey and those of children whose parents were
      nonresponders. Due to a serious administrative error in a study to examine
      health-related quality of life (HRQoL), all 514 eligible schoolchildren were
      tested, although only 177 parents signed consent. After deliberation, the
      relevant human research ethics committee gave permission to include all results
      in the analysis. The HRQoL was not different between the groups. Male children
      returned significantly fewer consent forms (p=.026). More of the nonresponding
      group reported that their parents "Never had enough time for them" (p=.023). The 
      high nonresponse rate and associations between response and parental interest and
      gender indicate that some bias may be introduced through the need for active
      consent, but overall there were no differences in responses to the quality of
      life questionnaire.
FAU - Jelsma, Jennifer
AU  - Jelsma J
AD  - Department of Health and Rehabilitation Sciences, University of Cape Town, Anzio 
      Road, Observatory, Cape Town 7925, SouthAfrica. Jennifer.jelsma@uct.ac.z
FAU - Burgess, Theresa
AU  - Burgess T
FAU - Henley, Lesley
AU  - Henley L
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Bias
MH  - *Ethics Committees, Research
MH  - Female
MH  - Health
MH  - Humans
MH  - *Informed Consent
MH  - Male
MH  - Parenting
MH  - *Parents
MH  - Quality of Life
MH  - Reproducibility of Results
MH  - *Research Design
MH  - *Schools
MH  - Sex Characteristics
MH  - *Statistics as Topic
MH  - Young Adult
EDAT- 2013/01/18 06:00
MHDA- 2013/06/19 06:00
CRDT- 2013/01/18 06:00
PHST- 2013/01/18 06:00 [entrez]
PHST- 2013/01/18 06:00 [pubmed]
PHST- 2013/06/19 06:00 [medline]
AID - 10.1525/jer.2012.7.5.56 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2012 Dec;7(5):56-62. doi: 10.1525/jer.2012.7.5.56.


PMID- 23324201
OWN - NLM
STAT- MEDLINE
DCOM- 20130618
LR  - 20130117
IS  - 1556-2654 (Electronic)
IS  - 1556-2646 (Linking)
VI  - 7
IP  - 5
DP  - 2012 Dec
TI  - Getting through ethics: the fit between research ethics board assessments and
      qualitative research.
PG  - 30-6
LID - 10.1525/jer.2012.7.5.30 [doi]
AB  - In this paper, we draw on the authors' collective experiences as qualitative
      researchers undergoing research ethics reviews. We highlight specific areas
      within our standard national guidelines that support qualitative research. Using 
      case examples, we illustrate how diverse interpretations of these guidelines can 
      be inconsistent and problematic for qualitative researchers. We outline
      recommendations for transparency, reciprocity, and streamlining of the review
      process. It is our hope that adoption of these recommendations will lead to a
      more collegial evaluative process, thereby contributing to the advancement of
      knowledge.
FAU - McCormack, Dianne
AU  - McCormack D
AD  - Department of Nursing & Health Sciences, University of New Brunswick, PO Box
      5050, Saint John, NB, Canada. dianne.mccormack@unb.ca
FAU - Carr, Tracy
AU  - Carr T
FAU - McCloskey, Rose
AU  - McCloskey R
FAU - Keeping-Burke, Lisa
AU  - Keeping-Burke L
FAU - Furlong, Karen E
AU  - Furlong KE
FAU - Doucet, Shelley
AU  - Doucet S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - *Ethics Committees, Research
MH  - *Ethics, Research
MH  - *Guidelines as Topic
MH  - Humans
MH  - *Qualitative Research
MH  - Research Personnel/*ethics
EDAT- 2013/01/18 06:00
MHDA- 2013/06/19 06:00
CRDT- 2013/01/18 06:00
PHST- 2013/01/18 06:00 [entrez]
PHST- 2013/01/18 06:00 [pubmed]
PHST- 2013/06/19 06:00 [medline]
AID - 10.1525/jer.2012.7.5.30 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2012 Dec;7(5):30-6. doi: 10.1525/jer.2012.7.5.30.


PMID- 23324200
OWN - NLM
STAT- MEDLINE
DCOM- 20130618
LR  - 20130117
IS  - 1556-2654 (Electronic)
IS  - 1556-2646 (Linking)
VI  - 7
IP  - 5
DP  - 2012 Dec
TI  - Psychotherapy researchers: reported misbehaviors and opinions.
PG  - 25-9
LID - 10.1525/jer.2012.7.5.25 [doi]
AB  - The ethical practices of psychotherapy researchers were surveyed online. A total 
      of 257 completed surveys were received from researchers worldwide. Eighty-nine
      percent of researchers admitted to at least one of the listed behaviors. The most
      common faults were related to excessive work demands: 44% of the respondents
      reported "inadequate monitoring of research projects due to work overload" and
      37% reported "cutting corners in a hurry to complete a project." North America
      was lower in almost all of the reported behaviors. The results about specific
      behaviors related to psychotherapy research for which rules are still fuzzy
      reflect the disagreement among researchers. The high prevalence of misbehavior in
      psychotherapy research is a warning that cannot be ignored.
FAU - Braun, Malena
AU  - Braun M
AD  - Universidad de Belgrano, Zabala1857CA 1428, CABA, Argentina. malenabraun@gmail
      .com
FAU - Roussos, Andres J
AU  - Roussos AJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - *Attitude
MH  - Data Collection
MH  - Humans
MH  - North America
MH  - Psychotherapy/*ethics
MH  - *Research
MH  - Research Personnel/*ethics
MH  - *Scientific Misconduct
MH  - Self Disclosure
MH  - *Workload
EDAT- 2013/01/18 06:00
MHDA- 2013/06/19 06:00
CRDT- 2013/01/18 06:00
PHST- 2013/01/18 06:00 [entrez]
PHST- 2013/01/18 06:00 [pubmed]
PHST- 2013/06/19 06:00 [medline]
AID - 10.1525/jer.2012.7.5.25 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2012 Dec;7(5):25-9. doi: 10.1525/jer.2012.7.5.25.


PMID- 23324199
OWN - NLM
STAT- MEDLINE
DCOM- 20130618
LR  - 20220317
IS  - 1556-2654 (Electronic)
IS  - 1556-2646 (Linking)
VI  - 7
IP  - 5
DP  - 2012 Dec
TI  - Factors associated with research wrongdoing in Nigeria.
PG  - 15-24
LID - 10.1525/jer.2012.7.5.15 [doi]
AB  - Concerns about research wrongdoing in biomedical research are growing in
      developing countries, where research ethics training and research regulatory
      systems are just emerging. In a first-time study in Africa, medical/dental
      researchers (N = 132) in two states in Nigeria were interviewed on a wide range
      of research wrongdoings and potential predictors. Using multivariate logistic
      regression, significant predictors of research wrongdoing were identified. Some
      22.0% admitted to at least one of fabrication, falsification, and plagiarism, the
      predictors of which were knowledge gaps in research ethics and pressure to
      publish enough papers for promotion. Acknowledging inadequate knowledge of
      research ethics was a predictor of admitting a wrongdoing. Systems that support
      ethical research, including skilled training and funding, are recommended.
FAU - Adeleye, Omokhoa A
AU  - Adeleye OA
AD  - Department of Community Health, University of Benin Teaching Hospital, Benin
      City, Edo State, Nigeria. adeleyeoa@gmail.com
FAU - Adebamowo, Clement A
AU  - Adebamowo CA
LA  - eng
GR  - R25 TW007091/TW/FIC NIH HHS/United States
GR  - R25TW007091/TW/FIC NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Deception
MH  - *Developing Countries
MH  - *Ethics, Research
MH  - Humans
MH  - Interviews as Topic
MH  - Nigeria
MH  - Plagiarism
MH  - *Professional Competence
MH  - *Publishing
MH  - *Scientific Misconduct
MH  - Self Disclosure
PMC - PMC3619034
MID - NIHMS451712
EDAT- 2013/01/18 06:00
MHDA- 2013/06/19 06:00
CRDT- 2013/01/18 06:00
PHST- 2013/01/18 06:00 [entrez]
PHST- 2013/01/18 06:00 [pubmed]
PHST- 2013/06/19 06:00 [medline]
AID - 10.1525/jer.2012.7.5.15 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2012 Dec;7(5):15-24. doi: 10.1525/jer.2012.7.5.15.


PMID- 23324197
OWN - NLM
STAT- MEDLINE
DCOM- 20130618
LR  - 20130117
IS  - 1556-2654 (Electronic)
IS  - 1556-2646 (Linking)
VI  - 7
IP  - 5
DP  - 2012 Dec
TI  - Globalization and the ethical responsibilities of researchers.
PG  - 1-2
LID - 10.1525/jer.2012.7.5.1 [doi]
FAU - Sieber, Joan E
AU  - Sieber JE
LA  - eng
PT  - Editorial
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - *Ethics, Research
MH  - Humans
MH  - *Internationality
MH  - Research Personnel/*ethics
EDAT- 2013/01/18 06:00
MHDA- 2013/06/19 06:00
CRDT- 2013/01/18 06:00
PHST- 2013/01/18 06:00 [entrez]
PHST- 2013/01/18 06:00 [pubmed]
PHST- 2013/06/19 06:00 [medline]
AID - 10.1525/jer.2012.7.5.1 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2012 Dec;7(5):1-2. doi: 10.1525/jer.2012.7.5.1.


PMID- 23318748
OWN - NLM
STAT- MEDLINE
DCOM- 20130410
LR  - 20191112
IS  - 1807-3107 (Electronic)
IS  - 1806-8324 (Linking)
VI  - 26 Suppl 1
DP  - 2012
TI  - Programmatic actions in oral health: coping with social inequities.
PG  - 81-5
LID - S1806-83242012000700012 [pii]
AB  - Inequities are health imbalances that are avoidable, unfair and unnecessary.
      Studies on health inequities address the need for emergency care related to
      oral-dental lesions from external causes, toothache or prevalence of oral
      lesions, taking into account the differences between individuals and/or
      populations in terms of risk conditions to acquiring disease or access to health 
      services. Inequities may be caused by the health service itself, because diseases
      affect socially deprived individuals more frequently and severely, especially
      because of multimorbidity. In the current Brazilian public health situation,
      programmatic actions are based on technological knowledge, especially
      epidemiology, focused on specific pathologies or disease risk groups, and relate 
      closely to the organization of programmed demand. Moreover, programmatic actions 
      should strategically use technological devices, without disregarding technical
      and policy flexibility, and should be closely related to inter-subjectivity and
      ethics, in order to develop emancipating capabilities. An action having this
      structure could make it easier to achieve Universality, Equity and Integrality.
FAU - Ferreira e Ferreira, Efigenia
AU  - Ferreira e Ferreira E
AD  - Department of Public Health, School of Dentistry, Univ Federal de Minas Gerais,
      Belo Horizonte, MG, Brazil. efigeniaf@gmail.com
FAU - Tomita, Nilce Emy
AU  - Tomita NE
FAU - Dalben, Gisele da Silva
AU  - Dalben Gda S
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - Braz Oral Res
JT  - Brazilian oral research
JID - 101307187
SB  - IM
MH  - Brazil
MH  - Health Promotion
MH  - Health Services Accessibility
MH  - *Healthcare Disparities
MH  - Humans
MH  - National Health Programs
MH  - *Oral Health
MH  - Public Health
MH  - Socioeconomic Factors
EDAT- 2013/01/18 06:00
MHDA- 2013/04/11 06:00
CRDT- 2013/01/16 06:00
PHST- 2012/09/28 00:00 [received]
PHST- 2012/10/31 00:00 [accepted]
PHST- 2013/01/16 06:00 [entrez]
PHST- 2013/01/18 06:00 [pubmed]
PHST- 2013/04/11 06:00 [medline]
AID - S1806-83242012000700012 [pii]
AID - 10.1590/s1806-83242012000700012 [doi]
PST - ppublish
SO  - Braz Oral Res. 2012;26 Suppl 1:81-5. doi: 10.1590/s1806-83242012000700012.


PMID- 23322969
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130117
LR  - 20220317
IS  - 0353-8109 (Print)
IS  - 0353-8109 (Linking)
VI  - 20
IP  - 3
DP  - 2012 Sep
TI  - Ethical aspects and dilemmas of preparing, writing and publishing of the
      scientific papers in the biomedical journals.
PG  - 141-8
LID - 10.5455/aim.2012.20.141-148 [doi]
AB  - INTRODUCTION: In this paper author discussed about preparing and submitting
      manuscripts - scientific, research, professional papers, reviews and case
      reports. Author described it from the Editor's perspective, and specially talked 
      about ethical aspects of authorship, conflict of interest, copyright, plagiarism 
      and duplicate publication from the point of view of his experiences as
      Editor-in-Chief of several biomedical journals and Chief of Task Force of
      European Federation of Medical Informatics journals and member of Task Force of
      European Cardiology Society journals. The scientific process relies on trust and 
      credibility. The scientific community demands high ethical standards to conduct
      biomedical research and to publish scientific contents. During the last decade,
      disclosure of conflicts of interest (COI ), (also called competing loyalties,
      competing interests or dual commitments), has been considered as a key element to
      guarantee the credibility of the scientific process. Biases in design, analysis
      and interpretation of studies may arise when authors or sponsors have vested
      interests. Therefore, COI should be made clear to the readers to facilitate their
      own judgment and interpretation of their relevance and potential implications.
      RESULTS AND DISCUSSION: Authors are responsible to fully disclose potential COI .
      In October 2009 the ICMJE proposed an electronic "uniform" format for COI
      disclosure. Four main areas were addressed: authors associations with entities
      that supported the submitted manuscript (indefinite time frame), associations
      with commercial entities with potential interest in the general area of the
      manuscript (time frame 36 months), financial association of their spouse and
      children and, finally, non-financial associations potentially relevant to the
      submitted manuscript. Consumers of medical scholarship expect a reliable system
      of disclosure in which journals and authors make disclosures appropriately and
      consistently. There is a stigma surrounding the reporting of COI that should be
      progressively overcome. Further actions are required to increase awareness of the
      importance of COI disclosure and to promote policies aimed to enhance
      transparency in biomedical research. In this article author discuss about
      important ethical dilemmas in preparing, writing and publishing of scientific
      manuscripts in biomedical journals.
FAU - Masic, Izet
AU  - Masic I
AD  - Academy of medical sciences of Bosnia and Herzegovina. Sarajevo, Bosnia and
      Herzegovina.
LA  - eng
PT  - Journal Article
PL  - Bosnia and Herzegovina
TA  - Acta Inform Med
JT  - Acta informatica medica : AIM : journal of the Society for Medical Informatics of
      Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH
JID - 101147064
PMC - PMC3508847
OTO - NOTNLM
OT  - acknowledgement
OT  - authorship
OT  - biomedical journals
OT  - conflict of interest
OT  - copyright
OT  - duplicate publication.
OT  - ethics
OT  - medical science
OT  - plagiarism
EDAT- 2013/01/17 06:00
MHDA- 2013/01/17 06:01
CRDT- 2013/01/17 06:00
PHST- 2012/06/25 00:00 [received]
PHST- 2012/07/30 00:00 [accepted]
PHST- 2013/01/17 06:00 [entrez]
PHST- 2013/01/17 06:00 [pubmed]
PHST- 2013/01/17 06:01 [medline]
AID - 10.5455/aim.2012.20.141-148 [doi]
AID - AIM-20-141 [pii]
PST - ppublish
SO  - Acta Inform Med. 2012 Sep;20(3):141-8. doi: 10.5455/aim.2012.20.141-148.


PMID- 23322968
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130117
LR  - 20211021
IS  - 0353-8109 (Print)
IS  - 0353-8109 (Linking)
VI  - 20
IP  - 3
DP  - 2012 Sep
TI  - Cooperation between research institutions and journals on research integrity
      cases: guidance from the committee on publication ethics (cope).
PG  - 136-40
LID - 10.5455/aim.2012.20.136-140 [doi]
AB  - Institutions and journals both have important duties relating to research and
      publication misconduct. Institutions are responsible for the conduct of their
      researchers and for encouraging a healthy research environment. Journals are
      responsible for the conduct of their editors, for safeguarding the research
      record, and for ensuring the reliability of everything they publish. It is
      therefore important for institutions and journals to communicate and collaborate 
      effectively on cases relating to research integrity. To achieve this, we make the
      following recommendations. Institutions should: have a research integrity officer
      (or office) and publish their contact details prominently; inform journals about 
      cases of proven misconduct that affect the reliability or attribution of work
      that they have published; respond to journals if they request information about
      issues, such as disputed authorship, misleading reporting, competing interests,
      or other factors, including honest errors, that could affect the reliability of
      published work; initiate inquiries into allegations of research misconduct or
      unacceptable publication practice raised by journals; have policies supporting
      responsible research conduct and systems in place for investigating suspected
      research misconduct.Journals should: publish the contact details of their
      editor-in-chief who should act as the point of contact for questions relating to 
      research and publication integrity; inform institutions if they suspect
      misconduct by their researchers, and provide evidence to support these concerns; 
      cooperate with investigations and respond to institutions' questions about
      misconduct allegations; be prepared to issue retractions or corrections
      (according to the COP E guidelines on retractions) when provided with findings of
      misconduct arising from investigations; have policies for responding to
      institutions and other organizations that investigate cases of research
      misconduct.
FAU - Wager, Elizabeth
AU  - Wager E
AD  - Publications Consultant, Sideview, Princes Risborough, UK.
FAU - Kleinert, Sabine
AU  - Kleinert S
LA  - eng
PT  - Journal Article
PL  - Bosnia and Herzegovina
TA  - Acta Inform Med
JT  - Acta informatica medica : AIM : journal of the Society for Medical Informatics of
      Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH
JID - 101147064
PMC - PMC3541569
OTO - NOTNLM
OT  - publication ethics.
OT  - scientific journals
EDAT- 2013/01/17 06:00
MHDA- 2013/01/17 06:01
CRDT- 2013/01/17 06:00
PHST- 2012/06/15 00:00 [received]
PHST- 2012/06/30 00:00 [accepted]
PHST- 2013/01/17 06:00 [entrez]
PHST- 2013/01/17 06:00 [pubmed]
PHST- 2013/01/17 06:01 [medline]
AID - 10.5455/aim.2012.20.136-140 [doi]
AID - AIM-20-136 [pii]
PST - ppublish
SO  - Acta Inform Med. 2012 Sep;20(3):136-40. doi: 10.5455/aim.2012.20.136-140.


PMID- 23320641
OWN - NLM
STAT- MEDLINE
DCOM- 20131216
LR  - 20130116
IS  - 1132-1989 (Print)
IS  - 1132-1989 (Linking)
VI  - 23
IP  - 79
DP  - 2012 Sep-Dec
TI  - [Fetal experimentation, transplantations, cosmetics and their connection with
      induced abortion].
PG  - 695-733
AB  - The increase in induced abortion produces large numbers of cells, tissues and
      organs, which are used in several fields of Medicine, either in research or in
      treatment. The main uses are in Cardiology, Hematology, Metabolism, Embryology,
      Neurology, Immunology, Ophthalmology, Dermatology and Transplantations. Flavor
      enhancers and cosmetics also benefit. Utilitarianism has led to an increase in
      abortion-originated cell and tissue banks. Abortion is justified through the
      manipulation of language. Vested interests give rise to complicity in researchers
      and society as a whole. Abortion and tissue 'donation' cannot be split; since
      fresh tissues are involved there is a symbiotic relationship between them. Valid 
      consent is not possible. A contradiction emerges, the nasciturus is not desired
      or valued but fetal organs are. When someone is deprived of his rights it is
      because another wants to enslave them. Research must have a moral base. Knowledge
      should not be increased at any price. Something that is legal and well
      intentioned is not always morally acceptable. The duty of omission is applicable.
      Means to achieve a goal must be ethical means. Educational efforts to restore
      respect for the human embryo and fetus must be promoted. Technical advances are
      not always in accordance with human nature and dignity. Research and treatment
      that do not resort to cells, tissues and organs obtained from induced abortions
      should be promoted.
FAU - Redondo Calderon, Jose Luis
AU  - Redondo Calderon JL
AD  - redondojoseluis@telefonica.net
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Experimentacion fetal, trasplantes, cosmetica y su relacion con el aborto
      provocado.
PL  - Spain
TA  - Cuad Bioet
JT  - Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y
      Etica Medica
JID - 101312976
RN  - 0 (Cosmetics)
SB  - IM
MH  - Abortion, Induced/*ethics
MH  - *Cosmetics
MH  - Female
MH  - Fetal Research/*ethics
MH  - Fetus/cytology
MH  - Humans
MH  - Pregnancy
MH  - Tissue Transplantation/*ethics
EDAT- 2013/01/17 06:00
MHDA- 2013/12/18 06:00
CRDT- 2013/01/17 06:00
PHST- 2011/12/26 00:00 [received]
PHST- 2012/11/11 00:00 [accepted]
PHST- 2013/01/17 06:00 [entrez]
PHST- 2013/01/17 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
PST - ppublish
SO  - Cuad Bioet. 2012 Sep-Dec;23(79):695-733.


PMID- 23320640
OWN - NLM
STAT- MEDLINE
DCOM- 20131216
LR  - 20130116
IS  - 1132-1989 (Print)
IS  - 1132-1989 (Linking)
VI  - 23
IP  - 79
DP  - 2012 Sep-Dec
TI  - The preembryo's short lifetime. The history of a word.
PG  - 677-94
AB  - This article is a study of the historical aspects that gave rise to the term
      'preembryo'. We look at how the appearance of this term was related with attempts
      to justify ethical aspects associated with the destruction of embryos in the
      context of in vitro fecundation. The first scientific article found using this
      term was written by Clifford Grobstein in 1979 and not, as many people think, the
      Warnock report in 1984, although the term was used decisively in the British
      parliament between 1984 and 1990, culminating in the parliamentary approval of
      human embryos for research purposes. In the United States, the term was promoted 
      by the Ethical Committee of the American Fertility Society in 1986. However, the 
      term hardly appears in recent reports. In scientific and bioethical literature
      there has been a gradual decrease in the frequency with which it is used. It
      seems that the word 'preembryo' reflected a new metabiological concept coined to 
      provide a basis for apparently scientific data in an attempt to avoid ethical
      aspects related with the destruction of human embryos in the absence of any
      unconditional respect towards the same. Once this goal had been achieved, the
      term was gradually abandoned.
FAU - Ferrer Colomer, Modesto
AU  - Ferrer Colomer M
AD  - Fundacion Kovacs, Hospital Mesa del Castillo, Murcia. modfercol@gmail.com
FAU - Pastor, Luis Miguel
AU  - Pastor LM
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - Spain
TA  - Cuad Bioet
JT  - Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y
      Etica Medica
JID - 101312976
SB  - IM
MH  - Embryo Disposition/ethics
MH  - Embryo Research/ethics
MH  - *Embryo, Mammalian
MH  - Embryology/history
MH  - Embryonic Development
MH  - History, 20th Century
MH  - Humans
MH  - *Terminology as Topic
MH  - Time Factors
EDAT- 2013/01/17 06:00
MHDA- 2013/12/18 06:00
CRDT- 2013/01/17 06:00
PHST- 2012/11/15 00:00 [received]
PHST- 2012/12/19 00:00 [accepted]
PHST- 2013/01/17 06:00 [entrez]
PHST- 2013/01/17 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
PST - ppublish
SO  - Cuad Bioet. 2012 Sep-Dec;23(79):677-94.


PMID- 23320639
OWN - NLM
STAT- MEDLINE
DCOM- 20131216
LR  - 20130116
IS  - 1132-1989 (Print)
IS  - 1132-1989 (Linking)
VI  - 23
IP  - 79
DP  - 2012 Sep-Dec
TI  - [Moral autonomy and conscientious objection in the surgical management of
      Jehova's witnesses].
PG  - 657-73
AB  - According to current Spanish law, patients are guaranteed the right to make
      decisions on the medical treatment they receive. However, this exercise of
      autonomy in health care causes ethical conflicts which are hard to resolve.
      Health workers' duty to assist patients and the concept of personal rights may
      lead health professionals to prescribe actions which are contrary to the
      patient's wishes. For example, in the case of Jehovah's Witnesses, the conscience
      of health professionals may prevent them from accepting the restrictions on
      treatments demanded by the patient's religious principles. The same right to
      moral autonomy which is guaranteed to the patient would also seem to guarantee
      the health professional's right to exercise conscientious objection. On the other
      hand, the right to medical assistance and to religious freedom will be observed
      only if both medical institutions and health professionals treat patients in a
      way which respects their beliefs. This text offers an ethical and legal analysis 
      of the issue based on Spanish law, as well as a proposal on how these problems
      should be dealt with in everyday practice.
FAU - Ojeda Rivero, Rafael
AU  - Ojeda Rivero R
AD  - Anestesiologia y Reanimacion, Hospital Universitario Virgen del Rocio de Sevilla.
      rafael.ojeda.sspa@juntadeandalucia.es
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Autonomia moral y objecion de conciencia en el tratamiento quirurgico de los
      testigos de Jehova
PL  - Spain
TA  - Cuad Bioet
JT  - Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y
      Etica Medica
JID - 101312976
SB  - IM
MH  - Humans
MH  - *Jehovah's Witnesses
MH  - *Morals
MH  - *Personal Autonomy
MH  - Refusal to Treat
MH  - Surgical Procedures, Operative/*ethics
MH  - *Treatment Refusal
EDAT- 2013/01/17 06:00
MHDA- 2013/12/18 06:00
CRDT- 2013/01/17 06:00
PHST- 2011/11/05 00:00 [received]
PHST- 2012/07/01 00:00 [accepted]
PHST- 2013/01/17 06:00 [entrez]
PHST- 2013/01/17 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
PST - ppublish
SO  - Cuad Bioet. 2012 Sep-Dec;23(79):657-73.


PMID- 23320637
OWN - NLM
STAT- MEDLINE
DCOM- 20131216
LR  - 20130116
IS  - 1132-1989 (Print)
IS  - 1132-1989 (Linking)
VI  - 23
IP  - 79
DP  - 2012 Sep-Dec
TI  - [Relationship health care professional-patient from personalistic perspective. To
      know how to communicate is like ethical imperative].
PG  - 631-9
AB  - The ability to communicate with patients is part of health care practice and
      contributes to the humanization of such care and to the objectives. With basic
      coaching tools and personalized attention, the life of the patient can be
      transformed from the first moments of intervention. Beyond words, patient, in all
      their multidimensionality, need to be comforted and fell that they are being
      taken care of. The health care professionals transmits information verbally and
      non-verbally. ''Positive'' consultations are described as warm, friendly, firm
      and reassuring, and there exists an emphatic response to the cognitive and
      emotional concerns of the patient. The opposite approach involves the assumption 
      of roles and a lack of empathy (paternalism, servility, authoritarianism,
      laissez-faire, etc.). The ability to communicate is an ethical need in health
      care training. A personalized perspective, open to transcendence, is especially
      suitable in the health field, where communication must take into account the
      complex reality that the patient is living.
FAU - Montaner Abasolo, M Carmen
AU  - Montaner Abasolo MC
AD  - Servicio de Farmacia, Hospital Arnau de Vilanova, Calle de San Clemente, 12.
      46015 Valencia. montaner_mar@gva.es
FAU - Soler Company, Enrique
AU  - Soler Company E
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - La relacion con el paciente desde la perspectiva personalista. saber comunicar,
      un imperativo etico.
PL  - Spain
TA  - Cuad Bioet
JT  - Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y
      Etica Medica
JID - 101312976
SB  - IM
MH  - *Communication
MH  - Empathy
MH  - Humans
MH  - Personhood
MH  - Professional-Patient Relations/*ethics
EDAT- 2013/01/17 06:00
MHDA- 2013/12/18 06:00
CRDT- 2013/01/17 06:00
PHST- 2012/01/29 00:00 [received]
PHST- 2012/07/15 00:00 [accepted]
PHST- 2013/01/17 06:00 [entrez]
PHST- 2013/01/17 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
PST - ppublish
SO  - Cuad Bioet. 2012 Sep-Dec;23(79):631-9.


PMID- 23320636
OWN - NLM
STAT- MEDLINE
DCOM- 20131216
LR  - 20130116
IS  - 1132-1989 (Print)
IS  - 1132-1989 (Linking)
VI  - 23
IP  - 79
DP  - 2012 Sep-Dec
TI  - [Ethical and legal implications of the determination of blood alcohol content in 
      the emergency department].
PG  - 622-30
AB  - Alcohol is the most widely consumed toxic in Spain. Excessive alcohol intake is
      responsible for a significant number of visits to emergency departments (EDs),
      and what occurs may not only have severe medical consequences, but also serious
      legal implications. Most Spanish EDs lack specific protocols concerning the
      correct determination of blood alcohol content (BAC). The present work aims to
      review the technical, ethical and legal problems surrounding this test. Since
      ethanol is metabolized in peripheral blood, blood extraction should be
      standardized in order to preserve the proper chain of custody. An emergency test 
      for BAC should be performed in two scenarios: patients with an altered level of
      consciousness of unknown origin (when health-care professionals act for the good 
      of the patient), and situations which may be penalized by law (when health-care
      professionals act for the good of the community). The latter would include
      traffic controls and traffic accidents, job-related accidents, criminal
      activities or harmful domestic behaviour. Health-care professionals are
      responsible for treating patients' clinical information with due respect and
      confidentiality. However, professional secrecy may be overridden by legal
      imperative in certain situations. It is necessary to promote conscious ethical
      decision-taking by the health-care professional, so that this responsibility does
      not solely depend on the juridical context.
FAU - Real de Asua, Diego
AU  - Real de Asua D
AD  - Servicio de Medicina Interna, Hospital Universitario La Princesa, Madrid.
      diego.realdeasua@gmail.com
FAU - Gonzalez-Cajal, Jesus
AU  - Gonzalez-Cajal J
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Implicaciones eticas y juridicas de la determinacion de alcoholemia en urgencias.
PL  - Spain
TA  - Cuad Bioet
JT  - Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y
      Etica Medica
JID - 101312976
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Confidentiality
MH  - Emergency Service, Hospital
MH  - Ethanol/*blood
MH  - Humans
MH  - Substance Abuse Detection/*ethics/*legislation & jurisprudence
EDAT- 2013/01/17 06:00
MHDA- 2013/12/18 06:00
CRDT- 2013/01/17 06:00
PHST- 2012/04/03 00:00 [received]
PHST- 2012/07/15 00:00 [accepted]
PHST- 2013/01/17 06:00 [entrez]
PHST- 2013/01/17 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
PST - ppublish
SO  - Cuad Bioet. 2012 Sep-Dec;23(79):622-30.


PMID- 23320635
OWN - NLM
STAT- MEDLINE
DCOM- 20131216
LR  - 20151119
IS  - 1132-1989 (Print)
IS  - 1132-1989 (Linking)
VI  - 23
IP  - 79
DP  - 2012 Sep-Dec
TI  - [Clinical research and prisoners: coercion and grounds to participate].
PG  - 605-20
AB  - AIM: To assess the coercion perceived, the quality of the information, and the
      reasons that lead prisoners to participate in clinical research. MATERIAL AND
      METHOD: Descriptive and multicenter study. Information was gathered on the
      social, demographic and penitentiary characteristics, perceived coercion, kind of
      information received and reasons that lead prisoners to take part in research.
      Both univariate and bivariate analyses were performed. Quantitative variables are
      expressed as mean or median, and qualitative ones as absolute numbers or
      percentages. Comparison between means is performed by a Student T-test, and
      between medians by a Mann-Whitney U-test. The research was approved by an
      accredited Ethical Research Committee. RESULTS: The sample comprises 110
      prisoners from 11 different prisons, mean age 41.8 (40.4-43.2) years. Of these
      105 were men and 8 non-Spanish. 83 prisoners (75.5%) opined they received high
      quality information about the clinical research; although, only 73 (66.4%)
      understood it completely. 104 (94.5%) felt no coercion and to 92.5% said they
      were guaranteed an anonymity. The reasons to be included in the research were:
      benefits for science (67.3%); benefit for future patients (65.5%); altruism
      (65.5%); possibility of improvement in the own illness (70%). Bivariate analyses 
      showed no differences that depended on the length of the sentence or educational 
      level. CONCLUSIONS: Spanish prisoners take part in clinical researches freely.
      The information provided on the research should be improved and be made more
      understandable. Altruism and benefits for the science are the principal reasons
      for participating in research.
FAU - Garcia-Guerrero, Julio
AU  - Garcia-Guerrero J
AD  - Centro Penitenciario de Castellon I, Crtra de Alcora km 10. 12006 Castellon.
      garciaj@comcas.es
FAU - Vera-Remartinez, Enrique J
AU  - Vera-Remartinez EJ
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Multicenter Study
TT  - Investigacion clinica y presos: coercion y motivos para participar.
PL  - Spain
TA  - Cuad Bioet
JT  - Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y
      Etica Medica
JID - 101312976
SB  - IM
MH  - Adult
MH  - Biomedical Research/*ethics
MH  - *Coercion
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - *Prisoners
MH  - Surveys and Questionnaires
EDAT- 2013/01/17 06:00
MHDA- 2013/12/18 06:00
CRDT- 2013/01/17 06:00
PHST- 2012/08/15 00:00 [received]
PHST- 2012/12/07 00:00 [accepted]
PHST- 2013/01/17 06:00 [entrez]
PHST- 2013/01/17 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
PST - ppublish
SO  - Cuad Bioet. 2012 Sep-Dec;23(79):605-20.


PMID- 23320373
OWN - NLM
STAT- MEDLINE
DCOM- 20130215
LR  - 20130116
IS  - 0016-9161 (Print)
IS  - 0016-9161 (Linking)
VI  - 69
IP  - 1
DP  - 2012
TI  - The physician Louis Odier and the medical market in Geneva (1774-1817).
PG  - 54-75
AB  - Louis Odier was an active physician in late Eighteenth century Geneva. Studying
      his medical practice conveys an idea of the social impact of a doctor on the
      local medical market at the time. He encountered a series of economic and
      professional difficulties for which he found original solutions. Convinced that
      the practicing physician was capable of offering the best services, he sought to 
      defend professional interests. By his intellectual and public activities, he
      contributed to medical knowledge and to medical policies; in his practice and by 
      his reflexive thought, he strove to draw the contours of an "ethical"
      professional figure.
FAU - Rieder, Philip
AU  - Rieder P
AD  - Institut d'ethique biomedicale, Centre medical universitaire, Rue Michel Servet
      1, CH-1311 Geneve 4. philip.rieder@unige.ch
LA  - eng
PT  - Biography
PT  - Historical Article
PT  - Journal Article
PL  - Switzerland
TA  - Gesnerus
JT  - Gesnerus
JID - 1257130
SB  - IM
MH  - General Practice/*history
MH  - History, 18th Century
MH  - History, 19th Century
MH  - Physician's Role/history
MH  - *Physician-Patient Relations/ethics
MH  - Switzerland
PS  - Odier L
FPS - Odier, Louis
EDAT- 2013/01/17 06:00
MHDA- 2013/02/16 06:00
CRDT- 2013/01/17 06:00
PHST- 2013/01/17 06:00 [entrez]
PHST- 2013/01/17 06:00 [pubmed]
PHST- 2013/02/16 06:00 [medline]
PST - ppublish
SO  - Gesnerus. 2012;69(1):54-75.


PMID- 23318901
OWN - NLM
STAT- MEDLINE
DCOM- 20140203
LR  - 20191027
IS  - 1606-7916 (Electronic)
IS  - 0036-3634 (Linking)
VI  - 54
IP  - 6
DP  - 2012 Nov-Dec
TI  - [Just sharing of benefits in ethical guidelines for international research].
PG  - 637-43
LID - S0036-36342012000600013 [pii]
AB  - Several ethical standards defined in guidelines for international biomedical
      research in humans have outlined what is considered just in research conducted in
      middle to low-income countries. Compliance with the standards outlined by these
      guidelines results in direct benefits to the health of the patients, who benefit 
      from improvements in infrastructure, increased local research capacity, and
      decrease in the burden of disease. In an overall view of the ethical standards,
      the benefits that need to be distributed equitably can be classified as:
      addressing the needs and/or priorities of the local research, making posttrial
      benefits available, fostering ancillary-care benefits, making the new theoretical
      and practical knowledge available, supporting health services as well as health
      and ethics research, and including in the informed consent the potential benefits
      that can be expected. It is necessary that those who deal with international
      research have knowledge about these ethical guidelines and their potential
      benefits to public health.
FAU - Paez-Moreno, Ricardo
AU  - Paez-Moreno R
AD  - Universidad Nacional Autonoma de Mexico, Mexico, DF. ricardomsps@yahoo.com
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Justa distribucion de beneficios en las declaraciones internacionales de etica en
      investigacion.
PL  - Mexico
TA  - Salud Publica Mex
JT  - Salud publica de Mexico
JID - 0404371
SB  - IM
MH  - Biomedical Research/*ethics
MH  - *Codes of Ethics
MH  - *Internationality
EDAT- 2013/01/16 06:00
MHDA- 2014/02/04 06:00
CRDT- 2013/01/16 06:00
PHST- 2012/02/20 00:00 [received]
PHST- 2012/08/01 00:00 [accepted]
PHST- 2013/01/16 06:00 [entrez]
PHST- 2013/01/16 06:00 [pubmed]
PHST- 2014/02/04 06:00 [medline]
AID - S0036-36342012000600013 [pii]
AID - 10.1590/s0036-36342012000600013 [doi]
PST - ppublish
SO  - Salud Publica Mex. 2012 Nov-Dec;54(6):637-43. doi:
      10.1590/s0036-36342012000600013.


PMID- 23317255
OWN - NLM
STAT- MEDLINE
DCOM- 20130702
LR  - 20190606
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Linking)
VI  - 13
IP  - 11
DP  - 2012
TI  - Des-gamma-carboxyprothrombin for early identification and prognosis of
      hepatocellular carcinoma--a case control study from western Nepal.
PG  - 5773-5
AB  - OBJECTIVE: To assess the diagnostic and prognostic value of AFP and
      des-gamma-carboxyprothrombin (DCP) in combination and alone for hepatocellular
      carcinoma. MATERIALS AND METHODS: A case control study carried out in the
      Department of Biochemistry of Manipal College of Medical Sciences, Pokhara, Nepal
      between 1st January 2010 and 31st December 2011. The variables collected were
      age, gender, BMI, total proteins, albumin, AST, ALT, total bilirubin, DCP, AFP.
      Approval for the study was obtained from the institutional research ethical
      committee. Estimation of AFP was performed by ELISA reader for all cases.
      Analysis was done using descriptive statistics and confidence interval (CI). The 
      data was analyzed using Excel 2003, R 2.8.0 Statistical Package for the Social
      Sciences (SPSS) for Windows Version 16.0 (SPSS Inc; Chicago, IL, USA) and the EPI
      Info 3.5.1 Windows Version. RESULTS: The mean age of HCC cases was 53.6+/-14.93
      yrs. The percentage of females was less than males in both cases (23%) and
      controls (29%). The specificity of DCP reached 100% when its values was equal or 
      greater than 150 (MAU/ml) for 0, 3, 6, 9, 12 months preceding the diagnosis of
      HCC. Similarly, the specificity for AFP was also nearly 100% when its value was
      equal or greater than 200 ng/ml 0, 3, 6, 9, 12 months earlier to the finding of
      HCC. The specificity of DCP (>/=40 MAU/mL) and AFP(>/=20 ng/mL) in combination
      was 93%, 97%, 95%, 96%, 97% in respect to 0, 3, 6, 9, 12 months prior to the
      diagnosis of HCC. CONCLUSION: The combination of both DCP and AFP will improve
      the finding of initial HCC and the sensitivity of these markers was utmost at the
      time of HCC identification and noticeably lesser at former time points.
FAU - Mittal, Ankush
AU  - Mittal A
AD  - Biochemistry, Nepalese Army Institute of Health Sciences, Kathmandu, Nepal.
      drmittala@gmail.com
FAU - Gupta, Satrudhan Pd
AU  - Gupta SP
FAU - Sathian, Brijesh
AU  - Sathian B
FAU - Sreedharan, Jayadevan
AU  - Sreedharan J
FAU - Poudel, Bibek
AU  - Poudel B
FAU - Yadav, Shambhu Kumar
AU  - Yadav SK
FAU - Pandeya, Dipendra Raj
AU  - Pandeya DR
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
RN  - 0 (Biomarkers)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Protein Precursors)
RN  - 0 (alpha-Fetoproteins)
RN  - 53230-14-1 (acarboxyprothrombin)
RN  - 9001-26-7 (Prothrombin)
SB  - IM
MH  - Biomarkers/*metabolism
MH  - Biomarkers, Tumor/*metabolism
MH  - Carcinoma, Hepatocellular/*diagnosis/metabolism
MH  - Case-Control Studies
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Liver Neoplasms/*diagnosis/metabolism
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Nepal
MH  - Prognosis
MH  - Protein Precursors/*metabolism
MH  - Prothrombin/*metabolism
MH  - ROC Curve
MH  - alpha-Fetoproteins/*metabolism
EDAT- 2013/01/16 06:00
MHDA- 2013/07/03 06:00
CRDT- 2013/01/16 06:00
PHST- 2013/01/16 06:00 [entrez]
PHST- 2013/01/16 06:00 [pubmed]
PHST- 2013/07/03 06:00 [medline]
AID - 10.7314/apjcp.2012.13.11.5773 [doi]
PST - ppublish
SO  - Asian Pac J Cancer Prev. 2012;13(11):5773-5. doi: 10.7314/apjcp.2012.13.11.5773.


PMID- 23316593
OWN - NLM
STAT- MEDLINE
DCOM- 20130528
LR  - 20130115
IS  - 1293-8505 (Print)
IS  - 1293-8505 (Linking)
IP  - 186
DP  - 2012 Dec
TI  - [Clinical situation, resuscitation and ethics].
PG  - 51-2
FAU - Baret, Marie-Catherine
AU  - Baret MC
AD  - Cadre de sante formateur, Ifsi Virginie-Olivier, CH Sainte-Anne, Paris, France.
      mc.baret@ch-sainte-anne.fr
FAU - Moutel, Gregoire
AU  - Moutel G
LA  - fre
PT  - Journal Article
TT  - Situation clinique, reanimation et ethique.
PL  - France
TA  - Rev Infirm
JT  - Revue de l'infirmiere
JID - 1267175
MH  - Coma/nursing
MH  - *Education, Nursing/ethics/legislation & jurisprudence
MH  - Ethics, Nursing/*education
MH  - Humans
MH  - Life Support Care/ethics
MH  - Medical Futility/ethics
MH  - Negotiating/methods/psychology
MH  - Professional-Family Relations/ethics
MH  - Resuscitation/education/*ethics/*nursing
MH  - Tissue and Organ Procurement/ethics
MH  - Withholding Treatment/ethics
EDAT- 2013/01/16 06:00
MHDA- 2013/05/29 06:00
CRDT- 2013/01/16 06:00
PHST- 2013/01/16 06:00 [entrez]
PHST- 2013/01/16 06:00 [pubmed]
PHST- 2013/05/29 06:00 [medline]
PST - ppublish
SO  - Rev Infirm. 2012 Dec;(186):51-2.


PMID- 23316464
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130515
LR  - 20211021
IS  - 2212-2761 (Print)
IS  - 2212-2761 (Linking)
VI  - 1
IP  - 2
DP  - 2012 May
TI  - Measuring cognitive outcomes in a pre-clinical bioethics course.
PG  - 92-7
LID - 10.1007/s40037-012-0014-3 [doi]
AB  - Medical schools universally accept the idea that bioethics courses are essential 
      components of education, but few studies which measure outcomes (i.e., knowledge 
      or retention) have demonstrated their educational value in the literature. The
      goal of this study was to examine whether core concepts of a pre-clinical
      bioethics course were learned and retained. Over the course of 2 years, a
      pre-test comprising 25 multiple-choice questions was administered to two classes 
      (2008-2010) of first-year medical students prior to the start of a 15-week ethics
      course, and an identical post-test was administered at the end of the course. A
      total of 189 students participated. Paired t tests showed a significant
      difference between pre-test scores and post-test scores. The pre-test average
      score was 69.8 %, and the post-test average was 82.6 %, an increase of 12.9 %
      after the ethics course. The pre- and post-test results also suggested a shift in
      difficulty level of the questions, with students finding identical questions
      easier after the intervention. Given the increase in post-test scores after the
      15-week intervention, the study suggests that core concepts in medical ethics
      were learned and retained. These results demonstrate that an introductory
      bioethics course can improve short-term outcomes in knowledge and comprehension, 
      and should provide impetus to educators to demonstrate improved educational
      outcomes in ethics at higher levels of B.S. Bloom's Taxonomy of Learning.
FAU - Fernandes, Ashley K
AU  - Fernandes AK
AD  - Department of Community Health, Wright State University Boonshoft School of
      Medicine, 290J White Hall, Dayton, OH 45435-0001 USA.
FAU - Borges, Nicole
AU  - Borges N
FAU - Rodabaugh, Heather
AU  - Rodabaugh H
LA  - eng
PT  - Journal Article
DEP - 20120428
PL  - Netherlands
TA  - Perspect Med Educ
JT  - Perspectives on medical education
JID - 101590643
PMC - PMC3540384
OTO - NOTNLM
OT  - Bioethics
OT  - Bloom's Taxonomy of Learning
OT  - Undergraduate medical education
EDAT- 2013/01/15 06:00
MHDA- 2013/01/15 06:01
CRDT- 2013/01/15 06:00
PHST- 2013/01/15 06:00 [entrez]
PHST- 2013/01/15 06:00 [pubmed]
PHST- 2013/01/15 06:01 [medline]
AID - 10.1007/s40037-012-0014-3 [doi]
AID - 14 [pii]
PST - ppublish
SO  - Perspect Med Educ. 2012 May;1(2):92-7. doi: 10.1007/s40037-012-0014-3. Epub 2012 
      Apr 28.


PMID- 23316201
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130115
LR  - 20211021
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 3
DP  - 2012
TI  - Functional perturbation of classical natural killer and innate lymphoid cells in 
      the oral mucosa during SIV infection.
PG  - 417
LID - 10.3389/fimmu.2012.00417 [doi]
AB  - Despite the fact that the majority of human pathogens are transmitted across
      mucosal surfaces, including the oral mucosae, oral immunity is poorly understood.
      Furthermore, because the normal flora of the oral cavity is vast and
      significantly diverse, host immunity must balance a complex system of tolerance
      and pathogen recognition. Due to the rapid recognition and response to pathogens,
      the innate immune system, including natural killer (NK) cells, likely plays a
      critical role in mediating this balance. Because logistical and ethical
      restraints limit access to significant quantities of human mucosal tissues,
      non-human primate models offer one of the best opportunities to study mucosal NK 
      cells. In this study we have identified both classical NK cells, as well as
      innate lymphoid cells (ILCs) in tonsillar and buccal tissues and oral-draining
      lymph nodes. Identified by mutually exclusive expression of NKG2A and NKp44, NK
      cells, and ILCs in the oral mucosa are generally phenotypically and functionally 
      analogous to their gut counterparts. NKG2A(+) NK cells were more cytotoxic while 
      NKp44(+) ILCs produced copious amounts of IL-17 and TNF-alpha. However, in
      contrast to gut, oral NK cells and ILCs both produced large quantities of
      IFN-gamma and the beta-chemokine, MIP-1beta. Also in contrast to what we have
      previously found in gut tissues of SIV-infected macaques, we found no reduction
      in NK cells during chronic SIV infection, but rather an expansion of ILCs in
      oral-draining lymph nodes and tonsils. These data suggest that the
      lentivirus-induced depletion of the NK cell/ILC compartment in the gut may be
      absent in the oral mucosa, but the inherent differences and SIV-induced
      alterations are likely to have significant impact on preventing oral
      opportunistic infections in lentiviral disease. Furthermore, these data extend
      our understanding of the oral innate immune system in general and could aid
      future studies evaluating the regulation of both normal oral flora and limiting
      transmission of oral mucosal pathogens.
FAU - Li, Haiying
AU  - Li H
AD  - Division of Immunology, New England Primate Research Center, Harvard Medical
      School, One Pine Hill Drive Southborough, MA, USA.
FAU - Reeves, R Keith
AU  - Reeves RK
LA  - eng
GR  - P30 AI060354/AI/NIAID NIH HHS/United States
GR  - P51 OD011103/OD/NIH HHS/United States
GR  - U19 AI067854/AI/NIAID NIH HHS/United States
PT  - Journal Article
DEP - 20130108
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC3539714
OTO - NOTNLM
OT  - HIV
OT  - SIV
OT  - innate lymphoid cells
OT  - natural killer cells
OT  - oral mucosa
EDAT- 2013/01/15 06:00
MHDA- 2013/01/15 06:01
CRDT- 2013/01/15 06:00
PHST- 2012/10/30 00:00 [received]
PHST- 2012/12/20 00:00 [accepted]
PHST- 2013/01/15 06:00 [entrez]
PHST- 2013/01/15 06:00 [pubmed]
PHST- 2013/01/15 06:01 [medline]
AID - 10.3389/fimmu.2012.00417 [doi]
PST - epublish
SO  - Front Immunol. 2013 Jan 8;3:417. doi: 10.3389/fimmu.2012.00417. eCollection 2012.


PMID- 23313357
OWN - NLM
STAT- MEDLINE
DCOM- 20140818
LR  - 20131119
IS  - 1532-1983 (Electronic)
IS  - 0261-5614 (Linking)
VI  - 32
IP  - 6
DP  - 2013 Dec
TI  - Propensity score analysis confirms the independent effect of parenteral nutrition
      on the risk of central venous catheter-related bloodstream infection in
      oncological patients.
PG  - 1050-4
LID - 10.1016/j.clnu.2012.12.006 [doi]
LID - S0261-5614(12)00277-4 [pii]
AB  - BACKGROUND & AIMS: Parenteral nutrition is known as a high-risk factor for
      central venous catheter-related bloodstream infection (CVC-RBSI) in cancer
      patients. Owing to ethical and technical problems, the studies in the literature 
      have nonrandomized designs and are therefore often confounded by biases. We
      performed a propensity score analysis to estimate the effect of parenteral
      nutrition on CVC-RBSI in digestive cancer patients who underwent chemotherapy.
      METHODS: Data were collected prospectively. A logistic regression model was used 
      to calculate a propensity score, which was the probability of receiving
      parenteral nutrition. Kaplan-Meier survival and Cox regression model were used to
      estimate the effect of the parenteral nutrition on CVC-RBSI after adjustment for 
      the propensity score. RESULTS: Before the propensity score analysis, the
      differences between patients with (n = 113) and without (n = 312) parenteral
      nutrition were identified including: male gender, body weight, weight loss,
      performance status, location of primary cancer, FOLFIRI, and previous long-term
      corticotherapy. After propensity score stratification, all of the covariates were
      balanced within each stratum. After adjustment, patients with parenteral
      nutrition were at a higher risk for CVC-RBSI. CONCLUSION: By using the propensity
      score analysis, this study confirmed that parenteral nutrition was an independent
      risk factor for CVC-RBSI in digestive cancer patients.
CI  - Copyright (c) 2012 Elsevier Ltd and European Society for Clinical Nutrition and
      Metabolism. All rights reserved.
FAU - Toure, Abdoulaye
AU  - Toure A
AD  - Inserm Unit 1060/Inra 1235, University of Lyon, Lyon, France; Clinical Nutrition 
      Intensive Care Unit, Croix Rousse Hospital, Hospices Civils of Lyon, 69004 Lyon, 
      France. Electronic address: abdoulayek2002@yahoo.fr.
FAU - Chambrier, Cecile
AU  - Chambrier C
FAU - Vanhems, Philippe
AU  - Vanhems P
FAU - Lombard-Bohas, Catherine
AU  - Lombard-Bohas C
FAU - Souquet, Jean-Christophe
AU  - Souquet JC
FAU - Ecochard, Rene
AU  - Ecochard R
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20121220
PL  - England
TA  - Clin Nutr
JT  - Clinical nutrition (Edinburgh, Scotland)
JID - 8309603
SB  - IM
MH  - Aged
MH  - Catheter-Related Infections/etiology/*pathology
MH  - Central Venous Catheters/*adverse effects
MH  - Digestive System Neoplasms/physiopathology/*therapy
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Parenteral Nutrition, Total/*adverse effects
MH  - Propensity Score
MH  - Proportional Hazards Models
MH  - Prospective Studies
MH  - Risk Factors
OTO - NOTNLM
OT  - Adjustment
OT  - Cancer
OT  - Catheter-related infection
OT  - Nonrandomised study
OT  - Parenteral nutrition
OT  - Propensity score
EDAT- 2013/01/15 06:00
MHDA- 2014/08/19 06:00
CRDT- 2013/01/15 06:00
PHST- 2012/07/26 00:00 [received]
PHST- 2012/11/26 00:00 [revised]
PHST- 2012/12/12 00:00 [accepted]
PHST- 2013/01/15 06:00 [entrez]
PHST- 2013/01/15 06:00 [pubmed]
PHST- 2014/08/19 06:00 [medline]
AID - S0261-5614(12)00277-4 [pii]
AID - 10.1016/j.clnu.2012.12.006 [doi]
PST - ppublish
SO  - Clin Nutr. 2013 Dec;32(6):1050-4. doi: 10.1016/j.clnu.2012.12.006. Epub 2012 Dec 
      20.


PMID- 23312796
OWN - NLM
STAT- MEDLINE
DCOM- 20140418
LR  - 20131216
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 98
DP  - 2013 Dec
TI  - Bioethical ambition, political opportunity and the European governance of
      patenting: the case of human embryonic stem cell science.
PG  - 286-92
LID - 10.1016/j.socscimed.2012.09.050 [doi]
LID - S0277-9536(12)00830-1 [pii]
AB  - Scientific progress in the life sciences is dependent on the governance of
      tensions between the economic potential of the innovation and the cultural
      response from society. Ownership of the scientific innovation through patenting
      is a necessary part of the realization of its economic value yet, in the case of 
      human embryonic stem cell (hESC) science, ownership of the human body and human
      life may offend fundamental cultural values. In the case of transnational
      patenting governance by the European Patent Office (EPO) and the European Union
      (EU), cross-national cultural conflict in the field of hESC science has produced 
      a political demand for a form of governance that can incorporate ethical as well 
      as economic judgements in its decision making. This paper explores how bioethics 
      has responded to this opportunity to establish itself as a form of expert
      authority for the negotiation and resolution of the cultural conflict. In so
      doing, it shows how the political struggle that has accompanied this bid for new 
      governance territory has been influenced both by the political tensions between
      the EPO and EU systems of patenting governance and the resistance of competing
      experts in law and science to a bioethical presence.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Salter, Brian
AU  - Salter B
AD  - Department of Political Economy, King's College London, Strand Campus, London
      WC2R 2LS, UK. Electronic address: brian.g.salter@kcl.ac.uk.
FAU - Salter, Charlotte
AU  - Salter C
AD  - Norwich Medical School, University of East Anglia, UK.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121220
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - *Bioethical Issues
MH  - Cultural Characteristics
MH  - Embryo Research/economics/*ethics/legislation & jurisprudence
MH  - *Embryonic Stem Cells
MH  - Europe
MH  - Humans
MH  - Patents as Topic/*ethics/legislation & jurisprudence
MH  - *Politics
MH  - Social Values
OTO - NOTNLM
OT  - Bioethics
OT  - Europe
OT  - Governance
OT  - Patenting
OT  - Stem cell science
EDAT- 2013/01/15 06:00
MHDA- 2014/04/20 06:00
CRDT- 2013/01/15 06:00
PHST- 2012/01/27 00:00 [received]
PHST- 2012/08/14 00:00 [revised]
PHST- 2012/09/05 00:00 [accepted]
PHST- 2013/01/15 06:00 [entrez]
PHST- 2013/01/15 06:00 [pubmed]
PHST- 2014/04/20 06:00 [medline]
AID - S0277-9536(12)00830-1 [pii]
AID - 10.1016/j.socscimed.2012.09.050 [doi]
PST - ppublish
SO  - Soc Sci Med. 2013 Dec;98:286-92. doi: 10.1016/j.socscimed.2012.09.050. Epub 2012 
      Dec 20.


PMID- 23312301
OWN - NLM
STAT- MEDLINE
DCOM- 20140418
LR  - 20131216
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 98
DP  - 2013 Dec
TI  - 'Wicked' ethics: Compliance work and the practice of ethics in HIV research.
PG  - 371-8
LID - 10.1016/j.socscimed.2012.10.030 [doi]
LID - S0277-9536(12)00827-1 [pii]
AB  - Using ethnographic material collected between 2003 and 2007 in five HIV clinics
      in the US, South Africa, Uganda, and Thailand, this article examines "official
      ethics" and "ethics on the ground." It compares the ethical conundrums clinic
      staff and researchers confront in their daily work as HIV researchers with the
      dilemmas officially identified as ethical issues by bioethicists and people
      responsible for ethics reviews and compliance with ethics regulations. The
      tangled relation between ethical problems and solutions invites a comparison to
      Rittel and Webber's "wicked problems." Official ethics' attempts to produce
      universal solutions often make ethics problems even more wickedly intractable.
      Ethics on the ground is in part a reaction to this intractability.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Heimer, Carol A
AU  - Heimer CA
AD  - Department of Sociology, Northwestern University, 1810 Chicago Ave., Evanston, IL
      60208, USA; American Bar Foundation, 750 N. Lake Shore Dr., Chicago, IL 60611,
      USA. Electronic address: c-heimer@northwestern.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20121220
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Anthropology, Cultural
MH  - *Bioethical Issues
MH  - Biomedical Research/*ethics
MH  - Ethical Review/*standards
MH  - HIV Infections/*therapy
MH  - Humans
MH  - South Africa
MH  - Thailand
MH  - Uganda
MH  - United States
OTO - NOTNLM
OT  - Compliance
OT  - Ethics regulation
OT  - Globalization
OT  - HIV/AIDS
OT  - Medical research
OT  - South Africa
OT  - Thailand
OT  - Uganda
EDAT- 2013/01/15 06:00
MHDA- 2014/04/20 06:00
CRDT- 2013/01/15 06:00
PHST- 2012/05/14 00:00 [received]
PHST- 2012/10/26 00:00 [revised]
PHST- 2012/10/30 00:00 [accepted]
PHST- 2013/01/15 06:00 [entrez]
PHST- 2013/01/15 06:00 [pubmed]
PHST- 2014/04/20 06:00 [medline]
AID - S0277-9536(12)00827-1 [pii]
AID - 10.1016/j.socscimed.2012.10.030 [doi]
PST - ppublish
SO  - Soc Sci Med. 2013 Dec;98:371-8. doi: 10.1016/j.socscimed.2012.10.030. Epub 2012
      Dec 20.


PMID- 23308335
OWN - NLM
STAT- MEDLINE
DCOM- 20130702
LR  - 20211021
IS  - 1937-8688 (Electronic)
VI  - 13
DP  - 2012
TI  - Comparative regional morphometric changes in human uterine artery before and
      during pregnancy.
PG  - 30
AB  - INTRODUCTION: Uterine artery undergoes structural modifications at different
      physiologic states. It is expected that due to its unique course, hemodynamic
      stresses in the vessel would vary resulting in differences in arterial
      dimensions. The objective of this study was to investigate regional morphometric 
      changes in the human uterine artery. METHODS: Twenty four uterine arteries (12
      each from non-gravid uteri and gravid uteri) were obtained during autopsy after
      ethical approval from women aged between 21 to 47 years. Sections from proximal, 
      middle and distal segments of the artery taken within 72 hours were processed for
      paraffin embedding, sectioned and stained with Mason's Trichrome. Micrographs of 
      the slides were analyzed using Scion Image Multiscan software. Data were entered 
      into and analyzed with Statistical Programme for Social Sciences. RESULTS: The
      pregnancy related increase in diameter and wall thickness are most pronounced in 
      the proximal segment. In the distal segment, however, wall thickness reduces
      significantly (p < 0.05). Intimal thickness was lesser in pregnancy compared to
      non-gravid state in all the segments. CONCLUSION: Regional morphometric changes
      in the uterine artery during pregnancy may be designed to regulate blood flow to 
      the uterus and placenta during pregnancy.
FAU - Obimbo, Moses M
AU  - Obimbo MM
AD  - Department of Human Anatomy, University of Nairobi, Kenya.
FAU - Ogeng'o, Julius A
AU  - Ogeng'o JA
FAU - Saidi, Hassan
AU  - Saidi H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20121013
PL  - Uganda
TA  - Pan Afr Med J
JT  - The Pan African medical journal
JID - 101517926
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Pregnancy
MH  - Tunica Media/*anatomy & histology
MH  - Uterine Artery/*anatomy & histology
MH  - Uterus/*blood supply
PMC - PMC3527064
OTO - NOTNLM
OT  - Morphometry
OT  - pregnancy
OT  - reproductive
OT  - uterine artery
EDAT- 2013/01/12 06:00
MHDA- 2013/07/03 06:00
CRDT- 2013/01/12 06:00
PHST- 2011/12/20 00:00 [received]
PHST- 2012/07/30 00:00 [accepted]
PHST- 2013/01/12 06:00 [entrez]
PHST- 2013/01/12 06:00 [pubmed]
PHST- 2013/07/03 06:00 [medline]
PST - ppublish
SO  - Pan Afr Med J. 2012;13:30. Epub 2012 Oct 13.


PMID- 23308085
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130114
LR  - 20211021
IS  - 1874-2106 (Electronic)
IS  - 1874-2106 (Linking)
VI  - 6
DP  - 2012
TI  - Dental tissue repair: novel models for tissue regeneration strategies.
PG  - 214-9
LID - 10.2174/1874210601206010214 [doi]
AB  - Studies have shown that dentin matrices contain reservoirs of bioactive molecules
      capable of directing tissue repair. Elucidating the release mechanisms of such
      endogenous growth factors will enhance our understanding of dentinpulp
      regeneration and support the development of novel treatment modalities to enhance
      dentin repair following trauma and disease. Current clinical practice using new
      materials which are perceived to maintain pulpal viability require biological
      evidence to assess their therapeutic benefit and there is a need for better
      effective methods of assessing therapeutic approaches to improving dentin
      regeneration at the cellular and tissue level. Experimental modelling of dentin
      regeneration is hampered by the lack of suitable models. In vivo and in vitro
      studies have yielded considerable information on the processes taking place, but 
      are limited, due to the cost, ethics and lack of cell/matrix interactions. Novel 
      organotypic models, whereby cells and tissues are cultured in situ may provide a 
      more suitable model system to facilitate dental tissue engineering and
      regeneration.
FAU - Sloan, Alastair J
AU  - Sloan AJ
AD  - Cardiff Institute for Tissue Engineering and Repair, School of Dentistry, Cardiff
      University, Heath Park, Cardiff, CF15 8AZ, UK ; Mineralised Tissue Group, Tissue 
      Engineering and Reparative Dentistry, School of Dentistry, Cardiff University,
      Heath Park Cardiff, CF15 8AZ, UK.
FAU - Lynch, Christopher D
AU  - Lynch CD
LA  - eng
GR  - G0600349/1/NC3RS_/National Centre for the Replacement, Refinement and Reduction
      of Animals in Research/United Kingdom
GR  - G0900954/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
DEP - 20121228
PL  - United Arab Emirates
TA  - Open Dent J
JT  - The open dentistry journal
JID - 101480503
PMC - PMC3540382
OTO - NOTNLM
OT  - Dentin-pulp complex
OT  - ex vivo
OT  - inflammation.
OT  - tissue regeneration
EDAT- 2013/01/12 06:00
MHDA- 2013/01/12 06:01
CRDT- 2013/01/12 06:00
PHST- 2012/07/05 00:00 [received]
PHST- 2012/08/10 00:00 [revised]
PHST- 2012/09/27 00:00 [accepted]
PHST- 2013/01/12 06:00 [entrez]
PHST- 2013/01/12 06:00 [pubmed]
PHST- 2013/01/12 06:01 [medline]
AID - 10.2174/1874210601206010214 [doi]
AID - TODENTJ-6-214 [pii]
PST - ppublish
SO  - Open Dent J. 2012;6:214-9. doi: 10.2174/1874210601206010214. Epub 2012 Dec 28.


PMID- 23304928
OWN - NLM
STAT- MEDLINE
DCOM- 20130226
LR  - 20151119
IS  - 1115-2613 (Print)
IS  - 1115-2613 (Linking)
VI  - 21
IP  - 3
DP  - 2012 Jul-Sep
TI  - Neurological disease burden in two semi-urban communities in South East Nigeria.
PG  - 317-9
AB  - BACKGROUND: Neurological disorders are a significant cause of morbidity and
      mortality worldwide. Urban hospital-based studies give some perspectives on the
      burden of neurological disease but there are no community-based studies from
      South East Nigeria. AIM: This study sought to screen for the scope and pattern of
      neurological dysfunction affecting inhabitants of two semi-urban communities in
      Enugu, South East Nigeria. METHODS: A descriptive, cross-sectional,
      questionnaire-based study of inhabitants living in Alfred Camp and Udi Siding
      communities in Enugu was carried out in March 2008. Using a structured
      questionnaire, house-to-house interview of the residents was conducted by doctors
      trained for this purpose. Residents' knowledge and experience of clinical
      features that suggest neurological dysfunction were ascertained. Informed consent
      was obtained and ethical approval obtained from the Ethics Committee of the
      University of Nigeria Teaching Hospital Enugu. Data obtained was analyzed using
      SPSS version 13.5. RESULTS: Completed questionnaires were 239 in number. There
      were 138 males and 101 females with age range of 18-75 years. Most respondents,
      127 (53.1%), were aged 21-30 years. Pain syndromes were most commnon with
      headache, low back pain and neuropathic pain accounting for the top 3
      neurological disorders. CONCLUSION: This study has suggested that pain syndromes 
      affect large numbers of people ordinarily resident in semi-urban communities in
      Enugu, South East Nigeria. These syndromes have an effect on quality of life.
      There is need for further large scale studies as well as increased public health 
      strategies for addressing neurological diseases including pain disorders.
FAU - Onwuekwe, I O
AU  - Onwuekwe IO
AD  - Neurology Unit, Department of Medicine, University of Nigeria Teaching Hospital, 
      Enugu, Nigeria. onwuekweio@yahoo.com
FAU - Ezeala Adikaibe, B
AU  - Ezeala Adikaibe B
FAU - Ekenze, S O
AU  - Ekenze SO
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Nigeria
TA  - Niger J Med
JT  - Nigerian journal of medicine : journal of the National Association of Resident
      Doctors of Nigeria
JID - 100888321
SB  - IM
EIN - Niger J Med. 2012 Oct-Dec;21(4):474. Ikenna, O O [corrected to Onwuekwe, I O];
      Ezeala-Adikaibe, B [corrected to Ezeala Adikaibe, B]; Oluchi, S E [corrected to
      Ekenze, S O]
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cost of Illness
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Memory Disorders/epidemiology
MH  - Middle Aged
MH  - Nervous System Diseases/*epidemiology
MH  - Nigeria/epidemiology
MH  - Pain/epidemiology
MH  - Sleep Wake Disorders/epidemiology
MH  - Surveys and Questionnaires
MH  - *Urban Population
MH  - Young Adult
EDAT- 2013/01/12 06:00
MHDA- 2013/02/27 06:00
CRDT- 2013/01/12 06:00
PHST- 2013/01/12 06:00 [entrez]
PHST- 2013/01/12 06:00 [pubmed]
PHST- 2013/02/27 06:00 [medline]
PST - ppublish
SO  - Niger J Med. 2012 Jul-Sep;21(3):317-9.


PMID- 23304024
OWN - NLM
STAT- MEDLINE
DCOM- 20130611
LR  - 20211021
IS  - 1526-6702 (Electronic)
IS  - 0730-2347 (Linking)
VI  - 39
IP  - 6
DP  - 2012
TI  - Aortic dissections in the elderly: ethical dilemmas of treatment.
PG  - 831-3
FAU - Estrera, Anthony L
AU  - Estrera AL
AD  - Department of Cardiothoracic and Vascular Surgery, University of Texas Medical
      School at Houston, Houston, Texas 77030, USA. Anthony.L.Estrera@uth.tmc.edu
FAU - Safi, Hazim J
AU  - Safi HJ
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Tex Heart Inst J
JT  - Texas Heart Institute journal
JID - 8214622
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aneurysm, Dissecting/*surgery
MH  - Aortic Aneurysm, Thoracic/*surgery
MH  - Decision Making/*ethics
MH  - *Ethics, Medical
MH  - Humans
MH  - Vascular Surgical Procedures/*ethics
PMC - PMC3528246
OTO - NOTNLM
OT  - Acute disease
OT  - age factors
OT  - aged, 70 and over
OT  - aged, 80 and over
OT  - aneurysm, dissecting/surgery
OT  - aortic aneurysm, thoracic/surgery
OT  - frail elderly
OT  - patient selection
OT  - risk assessment
OT  - risk factors
OT  - treatment outcome
EDAT- 2013/01/11 06:00
MHDA- 2013/06/12 06:00
CRDT- 2013/01/11 06:00
PHST- 2013/01/11 06:00 [entrez]
PHST- 2013/01/11 06:00 [pubmed]
PHST- 2013/06/12 06:00 [medline]
PST - ppublish
SO  - Tex Heart Inst J. 2012;39(6):831-3.


PMID- 23302617
OWN - NLM
STAT- MEDLINE
DCOM- 20131029
LR  - 20160607
IS  - 0578-1310 (Print)
IS  - 0578-1310 (Linking)
VI  - 50
IP  - 11
DP  - 2012 Nov
TI  - [Determination of resting energy expenditure in critically ill children
      experiencing mechanical ventilation].
PG  - 847-50
AB  - OBJECTIVE: Energy metabolism of critically ill children has its own
      characteristics, especially for those undergoing mechanical ventilation. We tried
      to assess the energy expenditure status and evaluate the use of predictive
      equations in such children. Moreover, the characteristics of the energy
      metabolism among various situation were explored. METHOD: Fifty critically ill
      children undergoing mechanical ventilation were selected in this study. Data
      produced during the 24 hours of mechanical ventilation were collected for
      computation of severity of illness. Resting energy expenditure (REE) was
      determined at 24 hours after mechanical ventilation (MREE). Predictive resting
      energy expenditure (PREE) was calculated for each subject using age-appropriate
      equations (Schofield-HTWT, White). The study was approved by the hospital medical
      ethics committee and obtained parental written informed consent. RESULT: The
      pediatric risk of mortality score 3 (PRISM3) and pediatric critical illness score
      (PCIS) were (7 +/- 3) and (82 +/- 4), respectively. MREE, Schofield-HTWT equation
      PREE and White equation PREE were (404.80 +/- 178.28), (462.82 +/- 160.38) and
      (427.97 +/- 152.30) kcal/d, respectively; 70% were hypometabolic and 10% were
      hypermetabolic. MREE and PREE which were calculated using Schofield-HTWT equation
      and White equation, both were higher than MREE (P = 0.029). Correlation analysis 
      was performed between PRISM3 and PCIS with MREE. There were no statistically
      significant correlation (P > 0.05). CONCLUSION: The hypometabolic response is
      apparent in critically ill children with mechanical ventilation; Schofield-HTWT
      equation and White equation could not predict energy requirements within
      acceptable clinical accuracy. In critically ill children undergoing mechanical
      ventilation, the energy expenditure is not correlated with the severity of
      illness.
FAU - Dong, Hong-ba
AU  - Dong HB
AD  - Pediatric Intensive Care Unit, Shanghai Children's Medical Center, Shanghai
      200127, China.
FAU - Yang, Yan-wen
AU  - Yang YW
FAU - Wang, Ying
AU  - Wang Y
FAU - Hong, Li
AU  - Hong L
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Er Ke Za Zhi
JT  - Zhonghua er ke za zhi = Chinese journal of pediatrics
JID - 0417427
SB  - IM
MH  - Basal Metabolism/physiology
MH  - Body Weight
MH  - Calorimetry, Indirect
MH  - Child
MH  - Child, Preschool
MH  - *Critical Illness
MH  - Energy Metabolism/*physiology
MH  - Female
MH  - Humans
MH  - Infant
MH  - Intensive Care Units, Pediatric
MH  - Male
MH  - Nutritional Requirements
MH  - Oxygen Consumption
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - *Respiration, Artificial
MH  - Rest/*physiology
MH  - Severity of Illness Index
EDAT- 2013/01/11 06:00
MHDA- 2013/10/30 06:00
CRDT- 2013/01/11 06:00
PHST- 2013/01/11 06:00 [entrez]
PHST- 2013/01/11 06:00 [pubmed]
PHST- 2013/10/30 06:00 [medline]
PST - ppublish
SO  - Zhonghua Er Ke Za Zhi. 2012 Nov;50(11):847-50.


PMID- 23302474
OWN - NLM
STAT- MEDLINE
DCOM- 20130319
LR  - 20130110
IS  - 1462-3994 (Electronic)
IS  - 1462-3994 (Linking)
VI  - 14
DP  - 2012 Dec 10
TI  - Human adipose tissue stem cells: relevance in the pathophysiology of obesity and 
      metabolic diseases and therapeutic applications.
PG  - e19
LID - 10.1017/erm.2012.13 [doi]
AB  - Stem cells are unique cells exhibiting self-renewing properties and the potential
      to differentiate into multiple specialised cell types. Totipotent or pluripotent 
      stem cells are generally abundant in embryonic or fetal tissues, but the use of
      discarded embryos as sources of these cells raises challenging ethical problems. 
      Adult stem cells can also differentiate into a wide variety of cell types. In
      particular, adult adipose tissue contains a pool of abundant and accessible
      multipotent stem cells, designated as adipose-derived stem cells (ASCs), that are
      able to replicate as undifferentiated cells, to develop as mature adipocytes and 
      to differentiate into multiple other cell types along the mesenchymal lineage,
      including chondrocytes, myocytes and osteocytes, and also into cells of
      endodermal and neuroectodermal origin, including beta-cells and neurons,
      respectively. An impairment in the differentiation potential and biological
      functions of ASCs may contribute to the development of obesity and related
      comorbidities. In this review, we summarise different aspects of the ASCs with
      special reference to the isolation and characterisation of these cell
      populations, their relation to the biochemical features of the adipose tissue
      depot of origin and to the metabolic characteristics of the donor subject and
      discuss some prospective therapeutic applications.
FAU - Cignarelli, Angelo
AU  - Cignarelli A
AD  - Department of Emergency and Organ Transplantation - Section of Internal Medicine,
      Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro,
      Bari, Italy.
FAU - Perrini, Sebastio
AU  - Perrini S
FAU - Ficarella, Romina
AU  - Ficarella R
FAU - Peschechera, Alessandro
AU  - Peschechera A
FAU - Nigro, Pasquale
AU  - Nigro P
FAU - Giorgino, Francesco
AU  - Giorgino F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20121210
PL  - England
TA  - Expert Rev Mol Med
JT  - Expert reviews in molecular medicine
JID - 100939725
SB  - IM
MH  - Adipocytes/*cytology/metabolism
MH  - Adipose Tissue/*cytology
MH  - Cell Differentiation
MH  - Humans
MH  - Metabolic Diseases/*etiology/therapy
MH  - Obesity/*etiology/therapy
MH  - Stem Cell Transplantation
MH  - Stem Cells/*cytology/metabolism
EDAT- 2013/01/11 06:00
MHDA- 2013/03/21 06:00
CRDT- 2013/01/11 06:00
PHST- 2013/01/11 06:00 [entrez]
PHST- 2013/01/11 06:00 [pubmed]
PHST- 2013/03/21 06:00 [medline]
AID - S1462399412000130 [pii]
AID - 10.1017/erm.2012.13 [doi]
PST - epublish
SO  - Expert Rev Mol Med. 2012 Dec 10;14:e19. doi: 10.1017/erm.2012.13.


PMID- 23301442
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20130110
IS  - 1115-2613 (Print)
IS  - 1115-2613 (Linking)
VI  - 21
IP  - 1
DP  - 2012 Jan-Mar
TI  - A reduction in radiographic exposure and image quality in film screen
      postero-anterior chest radiography.
PG  - 21-4
AB  - PURPOSE: To develop a protocol for the optimization of diagnostic chest
      radiography examination, the effect of radiographic exposure reduction on image
      quality is investigated. PROCEDURE: Fourty-eight adult patients presenting for
      posterior-anterior (PA) chest radiography in a tertiary health care centre were
      categorized into 3 groups to assess the effects of exposure (tube current/time
      mAs) reduction on clinical image quality using in film screen (FS) chest
      radiography. Images were obtained at existing departmental exposure protocol (T1)
      while a record of the exposure factors was made. Test exposures obtained by
      reducing average mAs values by 20% (T2) and 50% (T3) were used to obtain
      radiographic images of patients following normal ethically based clinical
      practice. To make up for the reduction in mAs, a 4% increase in the T1 kVp was
      used. The quality of images obtained with each exposure protocol was studied by
      two consultant radiologists, using the image quality criteria of the Commission
      of European Communities (CEC). Assessors used the method of ranked scoring and
      worked independently. RESULTS: Results showed no change in image quality
      following the 20% exposure (mAs) reduction. However, there was a significant
      change in image quality at 50% reduction of mAs values (P < 0.05) with higher
      image quality scores suggesting improved perceptibility of all assessed criteria 
      among the observers. CONCLUSION: Improving radiation protection of the patient
      while maintaining diagnostic quality of the radiographic image at reduced
      exposures is a clinically desirable development. This study will find application
      in current efforts at optimization of radiography procedures in the area of
      study.
FAU - Egbe, N O
AU  - Egbe NO
AD  - Department of Radiography, College of Medical Sciences, University of Calabar,
      Calabar, Nigeria. nneoyiegbe@yahoo.com
FAU - Egong, E A
AU  - Egong EA
FAU - Ekpo, E U
AU  - Ekpo EU
FAU - Inah, G B
AU  - Inah GB
LA  - eng
PT  - Journal Article
PL  - Nigeria
TA  - Niger J Med
JT  - Nigerian journal of medicine : journal of the National Association of Resident
      Doctors of Nigeria
JID - 100888321
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nigeria
MH  - *Radiation Dosage
MH  - Radiation Protection
MH  - Radiography, Thoracic/*methods
MH  - Statistics, Nonparametric
MH  - *X-Ray Intensifying Screens
EDAT- 2013/01/11 06:00
MHDA- 2013/02/13 06:00
CRDT- 2013/01/11 06:00
PHST- 2013/01/11 06:00 [entrez]
PHST- 2013/01/11 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
PST - ppublish
SO  - Niger J Med. 2012 Jan-Mar;21(1):21-4.


PMID- 23301381
OWN - NLM
STAT- MEDLINE
DCOM- 20130130
LR  - 20191112
IS  - 1020-3397 (Print)
IS  - 1020-3397 (Linking)
VI  - 18
IP  - 11
DP  - 2012 Nov
TI  - One health: perspectives on ethical issues and evidence from animal experiments.
PG  - 1170-3
AB  - Zoonoses constitute more than 60% of all known infectious diseases and 75% of
      emerging infectious diseases. Their impact is not monitored, prevented and
      treated in an integrated way. The efficacy of therapeutic interventions for
      zoonotic diseases is deemed to be comparable across species with scientifically
      valid results originating from a range of animal experiments. Ethical obligations
      limit the number of animals used in experiments as well as reduce repetition of
      studies. The evidence based on randomized controlled trails and systematic
      reviews for the effectiveness of health care interventions is often inconclusive.
      Subjecting human volunteers to risk in the absence of scientifically valid
      results from animal experiments is unethical. The One Health concept is a
      comparative, clinical approach directed towards zoonoses which present challenges
      to research workers and clinicians. Optimal health for all--One Health--should be
      underpinned by ethically conducted research in animals or humans and the results 
      should be complementary to both.
FAU - Asokan, G V
AU  - Asokan GV
AD  - Public Health Programme, College of Health Sciences, University of Bahrain,
      Manama. agv@health.gov.bh
FAU - Fedorowicz, Z
AU  - Fedorowicz Z
FAU - Tharyan, P
AU  - Tharyan P
FAU - Vanitha, A
AU  - Vanitha A
LA  - eng
PT  - Journal Article
PL  - Egypt
TA  - East Mediterr Health J
JT  - Eastern Mediterranean health journal = La revue de sante de la Mediterranee
      orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit
JID - 9608387
SB  - IM
CIN - East Mediterr Health J. 2013 Jun;19(6):580. PMID: 24975189
CIN - East Mediterr Health J. 2013 Jun;19(6):581. PMID: 24983123
MH  - Animal Experimentation/*ethics
MH  - Animals
MH  - Communicable Diseases/*veterinary
MH  - Communicable Diseases, Emerging/*prevention & control
MH  - Human Experimentation/ethics
MH  - Humans
MH  - Public Health
MH  - Reproducibility of Results
MH  - Sample Size
MH  - Zoonoses/*epidemiology
EDAT- 2013/01/11 06:00
MHDA- 2013/01/31 06:00
CRDT- 2013/01/11 06:00
PHST- 2013/01/11 06:00 [entrez]
PHST- 2013/01/11 06:00 [pubmed]
PHST- 2013/01/31 06:00 [medline]
AID - 10.26719/2012.18.11.1170 [doi]
PST - ppublish
SO  - East Mediterr Health J. 2012 Nov;18(11):1170-3. doi: 10.26719/2012.18.11.1170.


PMID- 23279990
OWN - NLM
STAT- MEDLINE
DCOM- 20130618
LR  - 20130102
IS  - 0013-7006 (Print)
IS  - 0013-7006 (Linking)
VI  - 38 Suppl 3
DP  - 2012 Dec
TI  - [Endophenotypes and autism spectrum disorders].
PG  - S67-9
LID - 10.1016/S0013-7006(12)70080-5 [doi]
LID - S0013-7006(12)70080-5 [pii]
AB  - Genetic factors of ASD stay unknown after 30 years of research. The concept of
      "endophenotype" seems an interesting approach toward these factors. "Enlarged
      phenotypes" in families of ASD persons could lead to the definition of ASD
      endophenotypes. "Enlarged phenotypes" include clinical symptoms, morphological
      and functional brain anomalies enlightening ASD physiopathology and brain
      physiology. Knowledge of endophenotypes will lead to ASD genetic risk factors.
      This knowledge will open ethical questions about prenatal diagnosis.
CI  - Copyright (c) 2012 L'Encephale. Published by Elsevier Masson SAS.. All rights
      reserved.
FAU - Sokolowsky, M
AU  - Sokolowsky M
AD  - Service de Pedopsychiatrie, Hopital Sainte-Marguerite, 13274 Marseille cedex 9,
      France. michel.sokolwsky@ap-hm.fr
FAU - Fakra, E
AU  - Fakra E
FAU - Azorin, J-M
AU  - Azorin JM
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Endophenotypes et tro ubles du spectre autistique.
PL  - France
TA  - Encephale
JT  - L'Encephale
JID - 7505643
SB  - IM
MH  - Adult
MH  - Animals
MH  - Brain/abnormalities/physiopathology
MH  - Child
MH  - Child Development Disorders,
      Pervasive/diagnosis/*genetics/physiopathology/psychology
MH  - Cognition Disorders/diagnosis/genetics/psychology
MH  - Diagnosis, Differential
MH  - Disease Models, Animal
MH  - Emotional Intelligence/genetics/physiology
MH  - *Endophenotypes
MH  - Ethics, Medical
MH  - Female
MH  - Gene-Environment Interaction
MH  - Genetic Linkage/genetics
MH  - Genetic Predisposition to Disease/genetics/psychology
MH  - Genetic Research
MH  - Humans
MH  - Infant, Newborn
MH  - Neural Pathways/abnormalities/physiopathology
MH  - Pregnancy
MH  - Prenatal Diagnosis/ethics/psychology
MH  - Risk Factors
MH  - Schizophrenia/diagnosis/genetics
MH  - Schizophrenic Psychology
MH  - Theory of Mind/physiology
EDAT- 2013/01/11 06:00
MHDA- 2013/06/19 06:00
CRDT- 2013/01/03 06:00
PHST- 2013/01/03 06:00 [entrez]
PHST- 2013/01/11 06:00 [pubmed]
PHST- 2013/06/19 06:00 [medline]
AID - S0013-7006(12)70080-5 [pii]
AID - 10.1016/S0013-7006(12)70080-5 [doi]
PST - ppublish
SO  - Encephale. 2012 Dec;38 Suppl 3:S67-9. doi: 10.1016/S0013-7006(12)70080-5.


PMID- 23138423
OWN - NLM
STAT- MEDLINE
DCOM- 20130208
LR  - 20121109
IS  - 0093-0334 (Print)
IS  - 0093-0334 (Linking)
VI  - Suppl
DP  - 2012 Nov-Dec
TI  - Accept no substitutes: the ethics of alternatives.
PG  - S16-8
LID - 10.1002/hast.102 [doi]
FAU - Marks, Joel
AU  - Marks J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Hastings Cent Rep
JT  - The Hastings Center report
JID - 0410447
SB  - IM
MH  - Animal Experimentation/*ethics
MH  - *Animal Rights/standards/trends
MH  - Animal Use Alternatives/*ethics
MH  - Animals
MH  - Disease Models, Animal
MH  - *Ethics, Research
MH  - Humans
MH  - *Models, Animal
MH  - Pain/etiology
MH  - Rodentia
MH  - Stress, Psychological/etiology
EDAT- 2013/01/11 06:00
MHDA- 2013/02/09 06:00
CRDT- 2012/11/10 06:00
PHST- 2012/11/10 06:00 [entrez]
PHST- 2013/01/11 06:00 [pubmed]
PHST- 2013/02/09 06:00 [medline]
AID - 10.1002/hast.102 [doi]
PST - ppublish
SO  - Hastings Cent Rep. 2012 Nov-Dec;Suppl:S16-8. doi: 10.1002/hast.102.


PMID- 23092518
OWN - NLM
STAT- MEDLINE
DCOM- 20130423
LR  - 20191112
IS  - 0394-6320 (Print)
IS  - 0394-6320 (Linking)
VI  - 25
IP  - 2 Suppl
DP  - 2012 Apr-Jun
TI  - Obstetrical, fetal and postnatal effects of gestational antiblastic chemotherapy:
      how to counsel cancer patients.
PG  - 33S-46S
AB  - At least one in a thousand pregnancies is complicated by cancer and, as the
      maternal age at pregnancy increases, numbers are growing. If chemotherapy cannot 
      be postponed, both doctors and patients face complex medical and ethical issues. 
      There is a conflict between optimal maternal therapy and fetal wellbeing.
      Treatment during the first trimester increases the risk of congenital
      malformations, spontaneous abortions and fetal death. Second and third trimester 
      exposure is less risky, but it can cause intrauterine growth retardation and low 
      birth weight. Other effects on pregnancy after the first trimester include
      premature birth, stillbirth, impaired functional development, myocardial toxicity
      and myelosuppression. Counseling and management of these cases are difficult,
      because literature is mostly represented by case reports or retrospective series 
      while randomized prospective studies or guidelines are lacking. Moreover,
      personal experience is often scanty due to the rarity of the condition. This
      article reviews the available data regarding the different aspects of systemic
      treatment of cancer during pregnancy to help oncologist and obstetricians in
      counseling their patients and treat them accordingly.
FAU - Del Pup, L
AU  - Del Pup L
AD  - Division of Gynecological Oncology, National Cancer Institute, Aviano (PN),
      Italy. ldelpup@cro.it
FAU - Peccatori, F A
AU  - Peccatori FA
FAU - Azim, H A Jr
AU  - Azim HA Jr
FAU - Michieli, M
AU  - Michieli M
FAU - Moioli, M
AU  - Moioli M
FAU - Giorda, G
AU  - Giorda G
FAU - Tirelli, U
AU  - Tirelli U
FAU - Berretta, M
AU  - Berretta M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Int J Immunopathol Pharmacol
JT  - International journal of immunopathology and pharmacology
JID - 8911335
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - *Abnormalities, Drug-Induced
MH  - Antineoplastic Agents/*adverse effects
MH  - *Counseling
MH  - Female
MH  - Fetus/*drug effects
MH  - Humans
MH  - Pregnancy
MH  - Pregnancy Complications, Neoplastic/*drug therapy
MH  - Pregnancy Outcome
MH  - Prenatal Exposure Delayed Effects
EDAT- 2013/01/11 06:00
MHDA- 2013/04/24 06:00
CRDT- 2012/10/25 06:00
PHST- 2012/10/25 06:00 [entrez]
PHST- 2013/01/11 06:00 [pubmed]
PHST- 2013/04/24 06:00 [medline]
AID - 3 [pii]
AID - 10.1177/03946320120250s203 [doi]
PST - ppublish
SO  - Int J Immunopathol Pharmacol. 2012 Apr-Jun;25(2 Suppl):33S-46S. doi:
      10.1177/03946320120250s203.


PMID- 23300663
OWN - NLM
STAT- MEDLINE
DCOM- 20130702
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 12
DP  - 2012
TI  - Robust and sensitive analysis of mouse knockout phenotypes.
PG  - e52410
LID - 10.1371/journal.pone.0052410 [doi]
AB  - A significant challenge of in-vivo studies is the identification of phenotypes
      with a method that is robust and reliable. The challenge arises from practical
      issues that lead to experimental designs which are not ideal. Breeding issues,
      particularly in the presence of fertility or fecundity problems, frequently lead 
      to data being collected in multiple batches. This problem is acute in high
      throughput phenotyping programs. In addition, in a high throughput environment
      operational issues lead to controls not being measured on the same day as
      knockouts. We highlight how application of traditional methods, such as a
      Student's t-Test or a 2-way ANOVA, in these situations give flawed results and
      should not be used. We explore the use of mixed models using worked examples from
      Sanger Mouse Genome Project focusing on Dual-Energy X-Ray Absorptiometry data for
      the analysis of mouse knockout data and compare to a reference range approach. We
      show that mixed model analysis is more sensitive and less prone to artefacts
      allowing the discovery of subtle quantitative phenotypes essential for
      correlating a gene's function to human disease. We demonstrate how a mixed model 
      approach has the additional advantage of being able to include covariates, such
      as body weight, to separate effect of genotype from these covariates. This is a
      particular issue in knockout studies, where body weight is a common phenotype and
      will enhance the precision of assigning phenotypes and the subsequent selection
      of lines for secondary phenotyping. The use of mixed models with in-vivo studies 
      has value not only in improving the quality and sensitivity of the data analysis 
      but also ethically as a method suitable for small batches which reduces the
      breeding burden of a colony. This will reduce the use of animals, increase
      throughput, and decrease cost whilst improving the quality and depth of knowledge
      gained.
FAU - Karp, Natasha A
AU  - Karp NA
AD  - Mouse Informatics Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge,
      United Kingdom. nk3@sanger.ac.uk
FAU - Melvin, David
AU  - Melvin D
CN  - Sanger Mouse Genetics Project
FAU - Mott, Richard F
AU  - Mott RF
LA  - eng
GR  - 090532/WT_/Wellcome Trust/United Kingdom
GR  - U54 HG006370/HG/NHGRI NIH HHS/United States
GR  - WT098051/WT_/Wellcome Trust/United Kingdom
GR  - 1 U54 HG006370-01/HG/NHGRI NIH HHS/United States
GR  - WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20121226
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Animals
MH  - Computational Biology/*methods
MH  - Data Mining
MH  - Female
MH  - *Gene Knockout Techniques
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Mice
MH  - *Phenotype
MH  - Reference Values
PMC - PMC3530558
EDAT- 2013/01/10 06:00
MHDA- 2013/07/03 06:00
CRDT- 2013/01/10 06:00
PHST- 2012/09/18 00:00 [received]
PHST- 2012/11/13 00:00 [accepted]
PHST- 2013/01/10 06:00 [entrez]
PHST- 2013/01/10 06:00 [pubmed]
PHST- 2013/07/03 06:00 [medline]
AID - 10.1371/journal.pone.0052410 [doi]
AID - PONE-D-12-28644 [pii]
PST - ppublish
SO  - PLoS One. 2012;7(12):e52410. doi: 10.1371/journal.pone.0052410. Epub 2012 Dec 26.


PMID- 23300409
OWN - NLM
STAT- MEDLINE
DCOM- 20130517
LR  - 20220409
IS  - 1553-7358 (Electronic)
IS  - 1553-734X (Linking)
VI  - 8
IP  - 12
DP  - 2012
TI  - Chapter 7: Pharmacogenomics.
PG  - e1002817
LID - 10.1371/journal.pcbi.1002817 [doi]
AB  - There is great variation in drug-response phenotypes, and a "one size fits all"
      paradigm for drug delivery is flawed. Pharmacogenomics is the study of how human 
      genetic information impacts drug response, and it aims to improve efficacy and
      reduced side effects. In this article, we provide an overview of
      pharmacogenetics, including pharmacokinetics (PK), pharmacodynamics (PD), gene
      and pathway interactions, and off-target effects. We describe methods for
      discovering genetic factors in drug response, including genome-wide association
      studies (GWAS), expression analysis, and other methods such as chemoinformatics
      and natural language processing (NLP). We cover the practical applications of
      pharmacogenomics both in the pharmaceutical industry and in a clinical setting.
      In drug discovery, pharmacogenomics can be used to aid lead identification,
      anticipate adverse events, and assist in drug repurposing efforts. Moreover,
      pharmacogenomic discoveries show promise as important elements of physician
      decision support. Finally, we consider the ethical, regulatory, and reimbursement
      challenges that remain for the clinical implementation of pharmacogenomics.
FAU - Karczewski, Konrad J
AU  - Karczewski KJ
AD  - Program in Biomedical Informatics, Stanford University, Stanford, California,
      United States of America.
FAU - Daneshjou, Roxana
AU  - Daneshjou R
FAU - Altman, Russ B
AU  - Altman RB
LA  - eng
GR  - R24 GM061374/GM/NIGMS NIH HHS/United States
GR  - T15 LM007033/LM/NLM NIH HHS/United States
GR  - U01 GM061374/GM/NIGMS NIH HHS/United States
GR  - T15-LM007033/LM/NLM NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Validation Study
DEP - 20121227
PL  - United States
TA  - PLoS Comput Biol
JT  - PLoS computational biology
JID - 101238922
SB  - IM
MH  - Drug Discovery
MH  - Genome-Wide Association Study
MH  - Humans
MH  - *Pharmacogenetics
PMC - PMC3531317
EDAT- 2013/01/10 06:00
MHDA- 2013/05/18 06:00
CRDT- 2013/01/10 06:00
PHST- 2013/01/10 06:00 [entrez]
PHST- 2013/01/10 06:00 [pubmed]
PHST- 2013/05/18 06:00 [medline]
AID - 10.1371/journal.pcbi.1002817 [doi]
AID - PCOMPBIOL-D-12-01392 [pii]
PST - ppublish
SO  - PLoS Comput Biol. 2012;8(12):e1002817. doi: 10.1371/journal.pcbi.1002817. Epub
      2012 Dec 27.


PMID- 23293763
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130108
LR  - 20211021
IS  - 2229-3485 (Print)
IS  - 2229-3485 (Linking)
VI  - 3
IP  - 4
DP  - 2012 Oct
TI  - Ethics committee composition.
PG  - 146-7
LID - 10.4103/2229-3485.103597 [doi]
FAU - Bhatt, Arun
AU  - Bhatt A
AD  - President, Clininvent Research Pvt. Ltd, A 302, Everest Chambers, Marol Naka,
      Andheri Kurla Road, Andheri (E), Mumbai, Maharshtra, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Perspect Clin Res
JT  - Perspectives in clinical research
JID - 101551517
PMC - PMC3530983
EDAT- 2013/01/08 06:00
MHDA- 2013/01/08 06:01
CRDT- 2013/01/08 06:00
PHST- 2013/01/08 06:00 [entrez]
PHST- 2013/01/08 06:00 [pubmed]
PHST- 2013/01/08 06:01 [medline]
AID - 10.4103/2229-3485.103597 [doi]
AID - PCR-3-146 [pii]
PST - ppublish
SO  - Perspect Clin Res. 2012 Oct;3(4):146-7. doi: 10.4103/2229-3485.103597.


PMID- 23293760
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130108
LR  - 20211021
IS  - 2229-3485 (Print)
IS  - 2229-3485 (Linking)
VI  - 3
IP  - 4
DP  - 2012 Oct
TI  - A study to assess completeness of project application forms submitted to
      Institutional Ethics Committees (IEC) of a tertiary care hospital.
PG  - 133-8
LID - 10.4103/2229-3485.103594 [doi]
AB  - OBJECTIVES: To review Ethics Committee (EC) application forms and to find out
      similarities and differences in content of five ECs forms in India. MATERIALS AND
      METHODS: THE COMPLETENESS OF EC APPLICATION FORMS WAS ASSESSED ON THE FOLLOWING
      THEMES: title, study team, sponsor responsibility, scientific aspects, patient
      safety, regulatory permissions, Informed consent process from 2008-2009.
      Application forms (available online) of 5 ECs were studied and compared. RESULTS:
      A total of 445 application forms were analyzed, 382 were academic, 63 were
      sponsored. The common deficiencies in academic studies were inappropriate titles 
      (25.13%), lack of budget details (90%). More than 95% studies had not mentioned
      the method of recruitment. The issue of vulnerability was not marked in more than
      50% of studies. Compensation for participation/injury was poorly stated in
      academic (99%) studies. Among industry sponsored studies, 98% were compliant with
      regulatory permissions and 41% were CTRI registered. The information pertaining
      to Informed Consent was mentioned in all forms. Comparative analysis of
      application forms of 5 ECs showed that the requirements for submission were
      similar except 1-2 ECs asked for additional information like percentage of time
      allotted by investigator for studies, GCP training of study team, certification
      by investigator regarding accuracy of local versions of Informed consent.
      CONCLUSION: Our study recommends that increased awareness and vigilance by
      investigators of academic studies regarding submission of applications to EC will
      increase efficiency and speed of review process. A common application form for
      all ECs across India would be an important step to achieve uniformity in
      functioning of ethics committees.
FAU - Shetty, Yashashri C
AU  - Shetty YC
AD  - Department of Pharmacology and Therapeutics, Seth GS Medical College and KEM
      Hospital, Parel, Mumbai, Maharashtra, India.
FAU - Marathe, Padmaja A
AU  - Marathe PA
FAU - Billa, Gauri V
AU  - Billa GV
FAU - Nambiar, C P Neelima
AU  - Nambiar CP
LA  - eng
PT  - Journal Article
PL  - India
TA  - Perspect Clin Res
JT  - Perspectives in clinical research
JID - 101551517
PMC - PMC3530980
OTO - NOTNLM
OT  - Academic
OT  - application form
OT  - clinical trial
OT  - completeness
OT  - ethics committee
OT  - sponsored
EDAT- 2013/01/08 06:00
MHDA- 2013/01/08 06:01
CRDT- 2013/01/08 06:00
PHST- 2013/01/08 06:00 [entrez]
PHST- 2013/01/08 06:00 [pubmed]
PHST- 2013/01/08 06:01 [medline]
AID - 10.4103/2229-3485.103594 [doi]
AID - PCR-3-133 [pii]
PST - ppublish
SO  - Perspect Clin Res. 2012 Oct;3(4):133-8. doi: 10.4103/2229-3485.103594.


PMID- 23293577
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130108
LR  - 20211021
IS  - 1661-8769 (Print)
IS  - 1661-8769 (Linking)
VI  - 3
IP  - 5
DP  - 2012 Nov
TI  - High-throughput sequencing and rare genetic diseases.
PG  - 197-203
LID - 10.1159/000343941 [doi]
AB  - High-throughput sequencing has drastically changed the research of genes
      responsible for genetic disorders and is now gradually introduced as an
      additional genetic diagnostic testing in clinical practice. The current debates
      on the emerging technical, medical and ethical issues as well as the potential
      optimum use of the available technology are discussed.
FAU - Makrythanasis, P
AU  - Makrythanasis P
AD  - Department of Genetic Medicine and Development, University of Geneva, Geneva,
      Switzerland.
FAU - Antonarakis, S E
AU  - Antonarakis SE
LA  - eng
PT  - Journal Article
DEP - 20121109
PL  - Switzerland
TA  - Mol Syndromol
JT  - Molecular syndromology
JID - 101525192
PMC - PMC3531930
OTO - NOTNLM
OT  - Diagnosis
OT  - Ethical aspects
OT  - Genetic disorders
OT  - Next-generation sequencing
OT  - Prenatal diagnosis
EDAT- 2013/01/08 06:00
MHDA- 2013/01/08 06:01
CRDT- 2013/01/08 06:00
PHST- 2013/01/08 06:00 [entrez]
PHST- 2013/01/08 06:00 [pubmed]
PHST- 2013/01/08 06:01 [medline]
AID - 10.1159/000343941 [doi]
AID - msy-0003-0197 [pii]
PST - ppublish
SO  - Mol Syndromol. 2012 Nov;3(5):197-203. doi: 10.1159/000343941. Epub 2012 Nov 9.


PMID- 23293444
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130108
LR  - 20211021
IS  - 0970-0218 (Print)
IS  - 0970-0218 (Linking)
VI  - 37
IP  - 4
DP  - 2012 Oct
TI  - Chargeless/Free availability of medical literature: the ethical need for
      development of global healthcare.
PG  - 264
LID - 10.4103/0970-0218.103478 [doi]
FAU - Deshpande, Prasanna R
AU  - Deshpande PR
AD  - Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, India
      E-mail: prasanna.deshpande17@gmail.com.
FAU - Naik, Anantha N
AU  - Naik AN
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Community Med
JT  - Indian journal of community medicine : official publication of Indian Association
      of Preventive & Social Medicine
JID - 9315574
PMC - PMC3531023
EDAT- 2013/01/08 06:00
MHDA- 2013/01/08 06:01
CRDT- 2013/01/08 06:00
PHST- 2013/01/08 06:00 [entrez]
PHST- 2013/01/08 06:00 [pubmed]
PHST- 2013/01/08 06:01 [medline]
AID - 10.4103/0970-0218.103478 [doi]
AID - IJCM-37-264 [pii]
PST - ppublish
SO  - Indian J Community Med. 2012 Oct;37(4):264. doi: 10.4103/0970-0218.103478.


PMID- 23293432
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130108
LR  - 20211021
IS  - 0970-0218 (Print)
IS  - 0970-0218 (Linking)
VI  - 37
IP  - 4
DP  - 2012 Oct
TI  - Surrogacy: ethical and legal issues.
PG  - 211-3
LID - 10.4103/0970-0218.103466 [doi]
AB  - Surrogacy refers to a contract in which a woman carries a pregnancy "for" another
      couple. Number of infertile couples from all over the World approach India where 
      commercial surrogacy is legal. Although this arrangement appears to be beneficial
      for all parties concerned,there are certain delicate issues which need to be
      addressed through carefully framed laws in order to protect the rights of the
      surrogate mother and the intended parents.
FAU - Saxena, Pikee
AU  - Saxena P
AD  - Department of Obstetrics and Gynecology, Lady Hardinge Medical College and
      Shrimati Sucheta Kriplani Hospital, New Delhi, India.
FAU - Mishra, Archana
AU  - Mishra A
FAU - Malik, Sonia
AU  - Malik S
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Community Med
JT  - Indian journal of community medicine : official publication of Indian Association
      of Preventive & Social Medicine
JID - 9315574
PMC - PMC3531011
OTO - NOTNLM
OT  - Surrogacy
OT  - altruistic
OT  - commercial
EDAT- 2013/01/08 06:00
MHDA- 2013/01/08 06:01
CRDT- 2013/01/08 06:00
PHST- 2012/07/25 00:00 [received]
PHST- 2012/07/25 00:00 [accepted]
PHST- 2013/01/08 06:00 [entrez]
PHST- 2013/01/08 06:00 [pubmed]
PHST- 2013/01/08 06:01 [medline]
AID - 10.4103/0970-0218.103466 [doi]
AID - IJCM-37-211 [pii]
PST - ppublish
SO  - Indian J Community Med. 2012 Oct;37(4):211-3. doi: 10.4103/0970-0218.103466.


PMID- 23293422
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130108
LR  - 20211021
IS  - 0300-1652 (Print)
IS  - 0300-1652 (Linking)
VI  - 53
IP  - 3
DP  - 2012 Jul
TI  - Ethical dilemma: Dental patient with HIV.
PG  - 178
LID - 10.4103/0300-1652.104393 [doi]
FAU - Pitak-Arnnop, Poramate
AU  - Pitak-Arnnop P
AD  - Department of Oral and Maxillofacial Surgery, UKGM GmbH, University Hospital of
      Marburg, Faculty of Medicine, Philipps University, Marburg, Germany.
FAU - Dhanuthai, Kittipong
AU  - Dhanuthai K
FAU - Hemprich, Alexander
AU  - Hemprich A
FAU - Pausch, Niels Christian
AU  - Pausch NC
LA  - eng
PT  - Journal Article
PL  - Nigeria
TA  - Niger Med J
JT  - Nigerian medical journal : journal of the Nigeria Medical Association
JID - 0315137
PMC - PMC3531041
EDAT- 2013/01/08 06:00
MHDA- 2013/01/08 06:01
CRDT- 2013/01/08 06:00
PHST- 2013/01/08 06:00 [entrez]
PHST- 2013/01/08 06:00 [pubmed]
PHST- 2013/01/08 06:01 [medline]
AID - 10.4103/0300-1652.104393 [doi]
AID - NMJ-53-178 [pii]
PST - ppublish
SO  - Niger Med J. 2012 Jul;53(3):178. doi: 10.4103/0300-1652.104393.


PMID- 23292631
OWN - NLM
STAT- MEDLINE
DCOM- 20130719
LR  - 20220330
IS  - 1735-9694 (Electronic)
IS  - 0044-6025 (Linking)
VI  - 50
IP  - 11
DP  - 2012
TI  - Attitude toward plagiarism among Iranian medical faculty members.
PG  - 778-81
AB  - The goal of this study was to assess attitude towards plagiarism in faculty
      members of Medical School at Tehran University of Medical Sciences. One hundred
      and twenty medical faculty members of Tehran University of Medical Sciences were 
      enrolled in this cross-sectional study. They were asked to answer to valid and
      reliable Persian version of attitude towards plagiarism questionnaire. Attitude
      toward plagiarism, positive attitude toward self-plagiarism and plagiarism
      acceptance were assessed. Eighty seven filled-up questionnaires were collected.
      Mean total number of correct answers was 11.6+/-3.1. Mean number of correct
      answers to questions evaluating self-plagiarism was 1.7+/-0.4 and mean number of 
      correct answers to questions evaluating plagiarism acceptance was 1.4+/-0.2.
      There was no significant correlation between plagiarism acceptance and
      self-plagiarism (r=0.17, P=0.1). It is essential to provide materials (such as
      workshops, leaflets and mandatory courses) to make Iranian medical faculty
      members familiar with medical research ethics issues such as plagiarism.
FAU - Ghajarzadeh, Mahsa
AU  - Ghajarzadeh M
AD  - Brain and Spinal Injury Research Center, Tehran University of Medical Sciences,
      Tehran, Iran.
FAU - Norouzi-Javidan, Abbas
AU  - Norouzi-Javidan A
FAU - Hassanpour, Kiana
AU  - Hassanpour K
FAU - Aramesh, Kiarash
AU  - Aramesh K
FAU - Emami-Razavi, Seyed Hassan
AU  - Emami-Razavi SH
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Acta Med Iran
JT  - Acta medica Iranica
JID - 14540050R
SB  - IM
CIN - Acta Med Iran. 2014;52(4):331. PMID: 24901868
MH  - Adult
MH  - Algorithms
MH  - *Attitude of Health Personnel
MH  - Cross-Sectional Studies
MH  - *Ethics, Professional
MH  - *Faculty, Medical
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Iran
MH  - Male
MH  - Middle Aged
MH  - *Plagiarism
MH  - Surveys and Questionnaires
EDAT- 2013/01/08 06:00
MHDA- 2013/07/20 06:00
CRDT- 2013/01/08 06:00
PHST- 2013/01/08 06:00 [entrez]
PHST- 2013/01/08 06:00 [pubmed]
PHST- 2013/07/20 06:00 [medline]
AID - 22826 [pii]
PST - ppublish
SO  - Acta Med Iran. 2012;50(11):778-81.


PMID- 23290293
OWN - NLM
STAT- MEDLINE
DCOM- 20130725
LR  - 20161125
IS  - 2245-1919 (Electronic)
IS  - 2245-1919 (Linking)
VI  - 59
IP  - 12
DP  - 2012 Dec
TI  - Transcatheter aortic valve implantation.
PG  - B4556
AB  - Transcatheter aortic valve implantation (TAVI) was introduced experimentally in
      1989, based on a newly developed heart valve prosthesis - the stentvalve. The
      valve was invented by a Danish cardiologist named Henning Rud Andersen. The new
      valve was revolutionary. It was foldable and could be inserted via a catheter
      through an artery in the groin, without the need for heart lung machine. This
      allowed for a new valve implantation technique, much less invasive than
      conventional surgical aortic valve replacement (SAVR). Surgical aortic valve
      replacement is safe and improves symptoms along with survival. However, up to 1/3
      of patients with aortic valve stenosis cannot complete the procedure due to
      frailty. The catheter technique was hoped to provide a new treatment option for
      these patients. The first human case was in 2002, but more widespread clinical
      use did not begin until 2006-2010. Today, in 2011, more than 40,000 valves have
      been implanted worldwide. Initially, because of the experimental character of the
      procedure, TAVI was reserved for patients who could not undergo SAVR due to high 
      risk. The results in this group of patients were promising. The procedural safety
      was acceptable, and the patients experienced significant improvements in their
      symptoms. Three of the papers in this PhD-thesis are based on the outcome of TAVI
      at Skejby Hospital, in this high-risk population [I, II and IV]. Along with other
      international publications, they support TAVI as being superior to standard
      medical treatment, despite a high risk of prosthetic regurgitation. These results
      only apply to high-risk patients, who cannot undergo SAVR. The main purpose of
      this PhD study has been to investigate the quality of TAVI compared to SAVR, in
      order to define the indications for this new procedure. The article attached [V] 
      describes a prospective clinical randomised controlled trial, between TAVI to
      SAVR in surgically amenable patients over 75 years of age with isolated aortic
      valve stenosis. The study was terminated prematurely, as patients undergoing TAVI
      showed a statistically non-significant trend towards more complications than SAVR
      patients. Although non-significant the study was closed for ethical reasons. At
      present, scientific evidence supports TAVI as being superior to standard medical 
      treatment, in patients who cannot undergo SAVR due to high- predicted risk.
      However, in patients who are surgically amenable, current publications suggest
      that TAVI using presently available devices is not competitive to SAVR, with
      regards to procedural safety and outcome.
FAU - Nielsen, Hans Henrik Moller
AU  - Nielsen HH
AD  - Department of Cardiothoracic Surgery, Aarhus University Hospital, Skejby,
      Brendstrupgardsvej 100, 8200 Aarhus, Denmark. hhmn@kirurgi.org
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
PL  - Denmark
TA  - Dan Med J
JT  - Danish medical journal
JID - 101576205
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aortic Valve Stenosis/diagnostic imaging/*surgery
MH  - Cardiac Catheterization/*methods
MH  - Female
MH  - Follow-Up Studies
MH  - *Heart Valve Prosthesis
MH  - Heart Valve Prosthesis Implantation/adverse effects/*methods
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Minimally Invasive Surgical Procedures/methods
MH  - Prosthesis Failure
MH  - Prosthesis Implantation
MH  - Risk Assessment
MH  - Treatment Outcome
MH  - Ultrasonography
EDAT- 2013/01/08 06:00
MHDA- 2013/07/26 06:00
CRDT- 2013/01/08 06:00
PHST- 2013/01/08 06:00 [entrez]
PHST- 2013/01/08 06:00 [pubmed]
PHST- 2013/07/26 06:00 [medline]
AID - B4556 [pii]
PST - ppublish
SO  - Dan Med J. 2012 Dec;59(12):B4556.


PMID- 23290092
OWN - NLM
STAT- MEDLINE
DCOM- 20130610
LR  - 20220410
IS  - 1876-035X (Electronic)
IS  - 1876-0341 (Linking)
VI  - 6
IP  - 1
DP  - 2013 Feb
TI  - Premarital Screening and Genetic Counseling program: knowledge, attitude, and
      satisfaction of attendees of governmental outpatient clinics in Jeddah.
PG  - 41-54
LID - 10.1016/j.jiph.2012.05.001 [doi]
LID - S1876-0341(12)00103-7 [pii]
AB  - UNLABELLED: Premarital care (PMC) is a worldwide activity that aims to diagnose
      and treat unrecognized disorders and reduce the transmission of diseases to
      couples and children. OBJECTIVES: To assess the knowledge and attitude of
      individuals attending governmental outpatient clinics regarding the Premarital
      Screening and Genetic Counseling (PMSGC) programs, to identify predictors of high
      knowledge scores and to determine the satisfaction and recommendations of clients
      of the program. METHODS: A cross-sectional study was conducted from January to
      April 2009. Individuals who attended three governmental hospital outpatient
      clinics on the day of the interview and agreed to participate in the study were
      recruited. The three hospitals were the two hospitals in Jeddah that offer the
      PMSGC programs and the King Abdulaziz University Hospital. Ethical considerations
      were followed and data were collected through an interview questionnaire that had
      been constructed for the study. The questionnaire asked for personal and
      socio-demographic data and for responses, on a 5-point Likert scale, to 30
      knowledge items and 14 attitude statements. Individuals who participated in the
      PMSGC program were asked questions regarding the services and activities of the
      program to ascertain their satisfaction with the program and their
      recommendations for program improvement. The statistical analysis was performed
      using SPSS version 16 (SPSS Inc., Chicago, IL). RESULTS: The sample included 655 
      participants, of whom 38.8% completed the PMSGC program. The participants'
      knowledge about the program was generally low. Education was the first predictor 
      of a high knowledge score; individuals having >/= university degree obtained a
      higher score (aOR=2.73; 95% CI: 1.77-4.20). The second predictor was the
      nationality of the participants, with Saudis gaining a higher score (aOR=2.04;
      95% CI: 1.002-4.16). The third predictor was monthly income. Regarding attitudes,
      the vast majority of participants (96.0%) strongly agreed on the importance of
      the program. Concerning the satisfaction levels of those who benefited from the
      program, 80.0% gave an excellent or very good score for program confidentiality, 
      whereas lower scores were given for counseling. Counseling before the tests was
      conducted for only 11.7% of the study participants. The majority of participants 
      recommended adding testing for other genetic diseases and STDs as well as
      additional topics for counseling. CONCLUSION: Knowledge in the general population
      about the PMSGC program was low. Implementation of school and university
      educational campaigns is important. Improved counseling and adding new topics for
      counseling on genetic, chronic, and psychiatric problems; building healthy
      families; reproduction and fertility are recommended.
CI  - Copyright (c) 2012 King Saud Bin Abdulaziz University for Health Sciences.
      Published by Elsevier Ltd. All rights reserved.
FAU - Ibrahim, Nahla Khamis
AU  - Ibrahim NK
AD  - Family and Community Medicine Department, Faculty of Medicine, King Abdulaziz
      University, Jeddah, Saudi Arabia. nahlakhamis@yahoo.com
FAU - Bashawri, Jamel
AU  - Bashawri J
FAU - Al Bar, Hussein
AU  - Al Bar H
FAU - Al Ahmadi, Jawaher
AU  - Al Ahmadi J
FAU - Al Bar, Adnan
AU  - Al Bar A
FAU - Qadi, Mahdi
AU  - Qadi M
FAU - Milaat, Waleed
AU  - Milaat W
FAU - Feda, Hashim
AU  - Feda H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121121
PL  - England
TA  - J Infect Public Health
JT  - Journal of infection and public health
JID - 101487384
SB  - IM
MH  - Adult
MH  - *Ambulatory Care Facilities
MH  - Cross-Sectional Studies
MH  - Female
MH  - Genetic Counseling/*organization & administration
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - *Patient Acceptance of Health Care/statistics & numerical data
MH  - Premarital Examinations/*methods
MH  - Saudi Arabia
EDAT- 2013/01/08 06:00
MHDA- 2013/06/12 06:00
CRDT- 2013/01/08 06:00
PHST- 2011/11/03 00:00 [received]
PHST- 2012/03/29 00:00 [revised]
PHST- 2012/05/25 00:00 [accepted]
PHST- 2013/01/08 06:00 [entrez]
PHST- 2013/01/08 06:00 [pubmed]
PHST- 2013/06/12 06:00 [medline]
AID - S1876-0341(12)00103-7 [pii]
AID - 10.1016/j.jiph.2012.05.001 [doi]
PST - ppublish
SO  - J Infect Public Health. 2013 Feb;6(1):41-54. doi: 10.1016/j.jiph.2012.05.001.
      Epub 2012 Nov 21.


PMID- 23289702
OWN - NLM
STAT- MEDLINE
DCOM- 20140124
LR  - 20211203
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 40
IP  - 4
DP  - 2012 Winter
TI  - What research ethics should learn from genomics and society research: lessons
      from the ELSI Congress of 2011.
PG  - 1008-24
LID - 10.1111/j.1748-720X.2012.00728.x [doi]
AB  - Research on the ethical, legal, and social implications (ELSI) of human genomics 
      has devoted significant attention to the research ethics issues that arise from
      genomic science as it moves through the translational process. Given the
      prominence of these issues in today's debates over the state of research ethics
      overall, these studies are well positioned to contribute important data,
      contextual considerations, and policy arguments to the wider research ethics
      community's deliberations, and ultimately to develop a research ethics that can
      help guide biomedicine's future. In this essay, we illustrate this thesis through
      an analytic summary of the research presented at the 2011 ELSI Congress, an
      international meeting of genomics and society researchers. We identify three
      pivotal factors currently shaping genomic research, its clinical translation, and
      its societal implications: (1) the increasingly blurred boundary between research
      and treatment; (2) uncertainty--that is, the indefinite, indeterminate, and
      incomplete nature of much genomic information and the challenges that arise from 
      making meaning and use of it; and (3) the role of negotiations between multiple
      scientific and non-scientific stakeholders in setting the priorities for and
      direction of biomedical research, as it is increasingly conducted "in the public 
      square."
CI  - (c) 2012 American Society of Law, Medicine & Ethics, Inc.
FAU - Henderson, Gail E
AU  - Henderson GE
AD  - Department of Social Medicine, School of Medicine, Center for Genomics and
      Society, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA.
FAU - Juengst, Eric T
AU  - Juengst ET
FAU - King, Nancy M P
AU  - King NM
FAU - Kuczynski, Kristine
AU  - Kuczynski K
FAU - Michie, Marsha
AU  - Michie M
LA  - eng
GR  - P50 HG004488/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Biological Specimen Banks/ethics
MH  - Disclosure/ethics
MH  - *Ethics, Research
MH  - Genetic Research/*ethics/legislation & jurisprudence
MH  - Genomics/*ethics
MH  - Humans
MH  - Incidental Findings
MH  - Informed Consent/ethics
MH  - Negotiating
MH  - Social Responsibility
MH  - Translational Research, Biomedical/ethics/legislation & jurisprudence
MH  - Uncertainty
PMC - PMC4103651
MID - NIHMS607341
EDAT- 2013/01/08 06:00
MHDA- 2014/01/25 06:00
CRDT- 2013/01/08 06:00
PHST- 2013/01/08 06:00 [entrez]
PHST- 2013/01/08 06:00 [pubmed]
PHST- 2014/01/25 06:00 [medline]
AID - 10.1111/j.1748-720X.2012.00728.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2012 Winter;40(4):1008-24. doi:
      10.1111/j.1748-720X.2012.00728.x.


PMID- 23289700
OWN - NLM
STAT- MEDLINE
DCOM- 20140124
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 40
IP  - 4
DP  - 2012 Winter
TI  - More than cheating: deception, IRB shopping, and the normative legitimacy of
      IRBs.
PG  - 990-6
LID - 10.1111/j.1748-720X.2012.00726.x [doi]
AB  - Deception, cheating, and loopholes within the IRB approval process have received 
      significant attention in the past several years. Surveys of clinical researchers 
      indicate common deception ranging from omitting information to outright lying,
      and controversy surrounding the FDA's decision not to ban "IRB shopping" (the
      practice of submitting protocols to multiple IRBs until one is found that will
      approve the protocol) has raised legitimate concerns about the integrity of the
      IRB process. While at first blush these practices seem to cast aspersions on the 
      integrity of clinical researchers, the moral issues raised go deeper than the
      ethics of cheating. To the extent that these practices are common, or represent
      an IRB system that places unreasonable burdens on those seeking IRB approval, we 
      should consider whether non-compliance reflects problems of normative legitimacy 
      for the IRB system itself.
CI  - (c) 2012 American Society of Law, Medicine & Ethics, Inc.
FAU - Spellecy, Ryan
AU  - Spellecy R
AD  - Center for Bioethics and Medical Humanities, the Medical College of Wisconsin,
      WI, USA.
FAU - May, Thomas
AU  - May T
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Consent Forms
MH  - *Deception
MH  - *Efficiency, Organizational
MH  - Ethics Committees, Research/*organization & administration/standards
MH  - Government Regulation
MH  - *Guideline Adherence
MH  - Humans
MH  - Professional Role
MH  - *Research Design
MH  - Research Personnel/ethics
MH  - United States
EDAT- 2013/01/08 06:00
MHDA- 2014/01/25 06:00
CRDT- 2013/01/08 06:00
PHST- 2013/01/08 06:00 [entrez]
PHST- 2013/01/08 06:00 [pubmed]
PHST- 2014/01/25 06:00 [medline]
AID - 10.1111/j.1748-720X.2012.00726.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2012 Winter;40(4):990-6. doi: 10.1111/j.1748-720X.2012.00726.x.


PMID- 23289698
OWN - NLM
STAT- MEDLINE
DCOM- 20140124
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 40
IP  - 4
DP  - 2012 Winter
TI  - IRB decision-making with imperfect knowledge: a framework for evidence-based
      research ethics review.
PG  - 951-69
LID - 10.1111/j.1748-720X.2012.00724.x [doi]
AB  - Here we describe the five steps of evidence-based practice as applied to research
      ethics review and apply these steps to three exemplar dilemmas: incentive
      payments in substance abuse research; informed consent for biobanking; and
      placebo-controlled trials involving pregnant women in order to demonstrate the
      potential of empirical data to inform and improve IRB decision-making.
CI  - (c) 2012 American Society of Law, Medicine & Ethics, Inc.
FAU - Anderson, Emily E
AU  - Anderson EE
AD  - Neiswanger Institute for Bioethics, Health Sciences Division, Loyola University
      Chicago, USA.
FAU - DuBois, James M
AU  - DuBois JM
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
RN  - 0 (Placebos)
MH  - Biological Specimen Banks/ethics
MH  - *Decision Making
MH  - *Ethics Committees, Research/legislation & jurisprudence
MH  - *Evidence-Based Practice
MH  - Female
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Informed Consent
MH  - Placebos
MH  - Pregnancy
MH  - Pregnancy Complications, Cardiovascular/prevention & control
MH  - Professional Competence
MH  - Public Policy
MH  - Remuneration
MH  - Research Design
MH  - Substance-Related Disorders/rehabilitation
MH  - Tissue Donors
MH  - *Uncertainty
MH  - United States
MH  - Venous Thromboembolism/prevention & control
EDAT- 2013/01/08 06:00
MHDA- 2014/01/25 06:00
CRDT- 2013/01/08 06:00
PHST- 2013/01/08 06:00 [entrez]
PHST- 2013/01/08 06:00 [pubmed]
PHST- 2014/01/25 06:00 [medline]
AID - 10.1111/j.1748-720X.2012.00724.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2012 Winter;40(4):951-69. doi:
      10.1111/j.1748-720X.2012.00724.x.


PMID- 23289696
OWN - NLM
STAT- MEDLINE
DCOM- 20140124
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 40
IP  - 4
DP  - 2012 Winter
TI  - A non-paternalistic model of research ethics and oversight: assessing the
      benefits of prospective review.
PG  - 930-44
LID - 10.1111/j.1748-720X.2012.00722.x [doi]
AB  - This paper offers a non-paternalistic justification for prospective research
      review as providing a credible social assurance that the institutions of
      scientific advancement respect and affirm the moral equality of all community
      members and as creating a "market" in which stakeholders working to advance
      diverse ends also advance the common good.
CI  - (c) 2012 American Society of Law, Medicine & Ethics, Inc.
FAU - London, Alex John
AU  - London AJ
AD  - Center for Ethics and Policy, Carnegie Mellon University, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Biomedical Research/*ethics/organization & administration
MH  - Dissent and Disputes
MH  - Ethics Committees, Research/*ethics/organization & administration
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Models, Organizational
MH  - Organizational Culture
MH  - Paternalism
MH  - Social Justice
MH  - *Social Responsibility
MH  - Trust
MH  - United States
EDAT- 2013/01/08 06:00
MHDA- 2014/01/25 06:00
CRDT- 2013/01/08 06:00
PHST- 2013/01/08 06:00 [entrez]
PHST- 2013/01/08 06:00 [pubmed]
PHST- 2014/01/25 06:00 [medline]
AID - 10.1111/j.1748-720X.2012.00722.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2012 Winter;40(4):930-44. doi:
      10.1111/j.1748-720X.2012.00722.x.


PMID- 23289694
OWN - NLM
STAT- MEDLINE
DCOM- 20140124
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 40
IP  - 4
DP  - 2012 Winter
TI  - Alive and well: the research imperative.
PG  - 915-21
LID - 10.1111/j.1748-720X.2012.00720.x [doi]
AB  - Many features of the existing biomedical research enterprise rest on questionable
      judgments about the value of research. Policymakers and research ethicists make
      assumptions about research value that aren't necessarily warranted. A more
      balanced view of research value could contribute to more defensible decisions
      about research policy and practice.
CI  - (c) 2012 American Society of Law, Medicine & Ethics, Inc.
FAU - Dresser, Rebecca
AU  - Dresser R
AD  - Washington University in St. Louis, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Biomedical Research/*ethics/*legislation & jurisprudence
MH  - Human Experimentation/ethics
MH  - Humans
MH  - Moral Obligations
MH  - *Public Policy
MH  - Stem Cell Research/ethics
MH  - United States
EDAT- 2013/01/08 06:00
MHDA- 2014/01/25 06:00
CRDT- 2013/01/08 06:00
PHST- 2013/01/08 06:00 [entrez]
PHST- 2013/01/08 06:00 [pubmed]
PHST- 2014/01/25 06:00 [medline]
AID - 10.1111/j.1748-720X.2012.00720.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2012 Winter;40(4):915-21. doi:
      10.1111/j.1748-720X.2012.00720.x.


PMID- 23289692
OWN - NLM
STAT- MEDLINE
DCOM- 20140124
LR  - 20211203
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 40
IP  - 4
DP  - 2012 Winter
TI  - Ethical dimensions of disparities in depression research and treatment in the
      pharmacogenomic era.
PG  - 886-903
LID - 10.1111/j.1748-720X.2012.00718.x [doi]
AB  - Disparities in access to, and utilization of, treatment for depression among
      African-American and Caucasian elderly adults have been well-documented. Less
      fully explored are the multidimensional factors responsible for these
      disparities. The intersection of cultural constructs, socioeconomic factors,
      multiple levels of racism, and stigma attending both mental health issues and
      older age may help to explain disparities in the treatment of the depressed
      elderly. Personalized medicine with its promise of developing interventions
      tailored to an individual's health needs and genetically related response to
      treatment might seem a promising antidote to the documented underutilization of
      standard depression treatments by African Americans. However, this paper examines
      the multidimensional factors associated with disparities in effective treatment
      of depression among African-American and Caucasian elderly adults and argues the 
      scientific and ethical importance of pursuing various paths to address multiple
      levels and sources of stigma and mistrust if pharmacogenomics is to help, rather 
      than exacerbate, disparities in depression treatment. Seven recommendations are
      offered to increase the likelihood that developments in pharmacogenomics will
      reduce disparities in depression treatment.
CI  - (c) 2012 American Society of Law, Medicine & Ethics, Inc.
FAU - Parker, Lisa S
AU  - Parker LS
AD  - Center for Bioethics and Health Law, University of Pittsburgh, USA.
FAU - Satkoske, Valerie B
AU  - Satkoske VB
LA  - eng
GR  - 1P30 MH071944A 01/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - African Americans/*genetics/psychology
MH  - Aged
MH  - Ageism
MH  - Depressive Disorder/*drug therapy/ethnology/genetics
MH  - Female
MH  - *Healthcare Disparities/ethics/ethnology
MH  - Humans
MH  - Male
MH  - Patient Acceptance of Health Care/*ethnology
MH  - Patient Selection/*ethics
MH  - Pharmacogenetics/*ethics
MH  - Precision Medicine/ethics
MH  - Racism
MH  - Socioeconomic Factors
MH  - Trust
MH  - United States
MH  - Whites
EDAT- 2013/01/08 06:00
MHDA- 2014/01/25 06:00
CRDT- 2013/01/08 06:00
PHST- 2013/01/08 06:00 [entrez]
PHST- 2013/01/08 06:00 [pubmed]
PHST- 2014/01/25 06:00 [medline]
AID - 10.1111/j.1748-720X.2012.00718.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2012 Winter;40(4):886-903. doi:
      10.1111/j.1748-720X.2012.00718.x.


PMID- 23289689
OWN - NLM
STAT- MEDLINE
DCOM- 20140124
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 40
IP  - 4
DP  - 2012 Winter
TI  - Introduction: research ethics: reexamining key concerns.
PG  - 865-6
LID - 10.1111/j.1748-720X.2012.00715.x [doi]
FAU - King, Nancy M P
AU  - King NM
AD  - Department of Social Sciences and Health Policy, Wake Forest Institute for
      Regenerative Medicine, Wake Forest School of Medicine, Wake Forest University,
      USA.
FAU - Iltis, Ana S
AU  - Iltis AS
LA  - eng
PT  - Introductory Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - *Ethics Committees, Research/ethics/standards
MH  - *Ethics, Research
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Professional Role
MH  - United States
EDAT- 2013/01/08 06:00
MHDA- 2014/01/25 06:00
CRDT- 2013/01/08 06:00
PHST- 2013/01/08 06:00 [entrez]
PHST- 2013/01/08 06:00 [pubmed]
PHST- 2014/01/25 06:00 [medline]
AID - 10.1111/j.1748-720X.2012.00715.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2012 Winter;40(4):865-6. doi: 10.1111/j.1748-720X.2012.00715.x.


PMID- 23289687
OWN - NLM
STAT- MEDLINE
DCOM- 20140124
LR  - 20211021
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 40
IP  - 4
DP  - 2012 Winter
TI  - Responsible conduct in nanomedicine research: environmental concerns beyond the
      common rule.
PG  - 848-55
LID - 10.1111/j.1748-720X.2012.00713.x [doi]
AB  - Nanomedicine research raises ethical concerns beyond those covered by the Common 
      Rule. Investigators and research institutions should comply with environmental
      and occupational health laws protect research staff and the environment. Though
      the IRB should concentrate on risks to human research participants, it should
      also consider risks to identifiable third parties. Investigators should also
      address risks to identifiable third parties. Professional and governmental
      organizations should deal with the long-term social, ethical, and environmental
      consequences of nanomedicine.
CI  - (c) 2012 American Society of Law, Medicine & Ethics, Inc.
FAU - Resnik, David B
AU  - Resnik DB
AD  - National Institute of Environmental Health Science, National Institutes of
      Health, USA.
LA  - eng
GR  - RC1 HG005338/HG/NHGRI NIH HHS/United States
GR  - ZIA ES102646-04/ImNIH/Intramural NIH HHS/United States
GR  - 1-RC1-HG005338-01/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, American Recovery and Reinvestment Act
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Clinical Trials as Topic/*ethics
MH  - Environmental Exposure/*prevention & control
MH  - Ethics Committees, Research
MH  - *Government Regulation
MH  - Humans
MH  - Malpractice/legislation & jurisprudence
MH  - Nanomedicine/*ethics
MH  - Nanostructures/adverse effects
MH  - Occupational Exposure/prevention & control
MH  - Public Health
MH  - *Risk Management/ethics/legislation & jurisprudence/methods
MH  - *Social Responsibility
MH  - United States
PMC - PMC3616622
MID - NIHMS451903
EDAT- 2013/01/08 06:00
MHDA- 2014/01/25 06:00
CRDT- 2013/01/08 06:00
PHST- 2013/01/08 06:00 [entrez]
PHST- 2013/01/08 06:00 [pubmed]
PHST- 2014/01/25 06:00 [medline]
AID - 10.1111/j.1748-720X.2012.00713.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2012 Winter;40(4):848-55. doi:
      10.1111/j.1748-720X.2012.00713.x.


PMID- 23289686
OWN - NLM
STAT- MEDLINE
DCOM- 20140124
LR  - 20211203
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 40
IP  - 4
DP  - 2012 Winter
TI  - Beyond human subjects: risk, ethics, and clinical development of nanomedicines.
PG  - 841-7
LID - 10.1111/j.1748-720X.2012.00712.x [doi]
AB  - Clinical testing of nanomedicines presents two challenges to prevailing, human
      subject-centered frameworks governing research ethics. First, some nanomedical
      applications may present risk to persons other than research subjects. Second,
      pressures encountered in testing nanomedicines may present threats to the kinds
      of collaborations and collective activities needed for supporting clinical
      translation and redeeming research risk. In this article, I describe how similar 
      challenges were encountered and addressed in gene transfer, and sketch policy
      options that might be explored in the nanomedicine translation arena.
CI  - (c) 2012 American Society of Law, Medicine & Ethics, Inc.
FAU - Kimmelman, Jonathan
AU  - Kimmelman J
AD  - Biomedical Ethics Unit/Social Studies of Medicine, McGill University, Montreal,
      Quebec.
LA  - eng
GR  - 1-RC1-HG005338-01/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, American Recovery and Reinvestment Act
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Clinical Trials as Topic/*ethics
MH  - Environmental Exposure/prevention & control
MH  - Ethics Committees, Research
MH  - Gene Transfer Techniques/adverse effects
MH  - *Government Regulation
MH  - Humans
MH  - Nanomedicine/*ethics
MH  - Nanostructures/adverse effects
MH  - Public Health
MH  - *Risk Management
MH  - *Social Responsibility
MH  - Translational Research, Biomedical/*ethics/organization & administration
MH  - United States
EDAT- 2013/01/08 06:00
MHDA- 2014/01/25 06:00
CRDT- 2013/01/08 06:00
PHST- 2013/01/08 06:00 [entrez]
PHST- 2013/01/08 06:00 [pubmed]
PHST- 2014/01/25 06:00 [medline]
AID - 10.1111/j.1748-720X.2012.00712.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2012 Winter;40(4):841-7. doi: 10.1111/j.1748-720X.2012.00712.x.


PMID- 23289683
OWN - NLM
STAT- MEDLINE
DCOM- 20140124
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 40
IP  - 4
DP  - 2012 Winter
TI  - Concepts of risk in nanomedicine research.
PG  - 809-22
LID - 10.1111/j.1748-720X.2012.00709.x [doi]
AB  - Risk takes center stage in ethical debates over nanomedical technologies. Yet
      concepts of risk may hold different meanings, and they are embedded within
      particular political, economic, and social contexts. This article discusses
      framings of risk in debates over medical innovations such as nanomedicine, and
      draws attention to organizational and institutional forms of risk which are less 
      visible in bioethical policy debates. While significant, possibly unique risks
      may exist in specific nano-based products, risk may also arise from the very
      processes and procedures that develop, test, and oversee any novel technology.
      This supports recommendations to coordinate efforts through an interagency
      Working Group and a Secretary-level Advisory Committee to provide flexibility and
      sensitivity to emerging issues of concern.
CI  - (c) 2012 American Society of Law, Medicine & Ethics, Inc.
FAU - Hogle, Linda F
AU  - Hogle LF
AD  - Medical Social Sciences, University of Wisconsin-Madison, Madison, WI, USA.
LA  - eng
GR  - 1-RC1-HG005338-01/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Advisory Committees
MH  - Ethics Committees, Research/*organization & administration
MH  - *Government Regulation
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Interinstitutional Relations
MH  - Nanomedicine/*ethics
MH  - Politics
MH  - Risk
MH  - *Risk Management/ethics/organization & administration
MH  - Uncertainty
MH  - United States
EDAT- 2013/01/08 06:00
MHDA- 2014/01/25 06:00
CRDT- 2013/01/08 06:00
PHST- 2013/01/08 06:00 [entrez]
PHST- 2013/01/08 06:00 [pubmed]
PHST- 2014/01/25 06:00 [medline]
AID - 10.1111/j.1748-720X.2012.00709.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2012 Winter;40(4):809-22. doi:
      10.1111/j.1748-720X.2012.00709.x.


PMID- 23289682
OWN - NLM
STAT- MEDLINE
DCOM- 20140124
LR  - 20211203
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 40
IP  - 4
DP  - 2012 Winter
TI  - Building an ethical foundation for first-in-human nanotrials.
PG  - 802-8
LID - 10.1111/j.1748-720X.2012.00708.x [doi]
AB  - Novel nanomedical interventions require human testing to evaluate their safety
      and effectiveness. To establish a proper evidentiary basis for human trials,
      nanomedical innovations must first be subjected to animal and other laboratory
      testing. But it is uncertain whether the traditional laboratory approaches to
      safety evaluation will supply adequate information on nanotechnology risks to
      humans. This uncertainty, together with other features of nanomedical innovation,
      heightens the ethical challenges in conducting FIH nanotrials.
CI  - (c) 2012 American Society of Law, Medicine & Ethics, Inc.
FAU - Dresser, Rebecca
AU  - Dresser R
AD  - Washington University in St. Louis, USA.
LA  - eng
GR  - RC1 HG005338/HG/NHGRI NIH HHS/United States
GR  - UL1 TR000448/TR/NCATS NIH HHS/United States
GR  - 1-RC1-HG005338-01/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, American Recovery and Reinvestment Act
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - *Government Regulation
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Nanomedicine/*ethics
MH  - *Risk Management
MH  - Translational Research, Biomedical/*ethics
MH  - United States
PMC - PMC3619225
MID - NIHMS450847
EDAT- 2013/01/08 06:00
MHDA- 2014/01/25 06:00
CRDT- 2013/01/08 06:00
PHST- 2013/01/08 06:00 [entrez]
PHST- 2013/01/08 06:00 [pubmed]
PHST- 2014/01/25 06:00 [medline]
AID - 10.1111/j.1748-720X.2012.00708.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2012 Winter;40(4):802-8. doi: 10.1111/j.1748-720X.2012.00708.x.


PMID- 23289679
OWN - NLM
STAT- MEDLINE
DCOM- 20140124
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 40
IP  - 4
DP  - 2012 Winter
TI  - A portrait of nanomedicine and its bioethical implications.
PG  - 763-79
LID - 10.1111/j.1748-720X.2012.00705.x [doi]
AB  - This review addresses the current and future potential of nanomedicine, and its
      ethical considerations within the comprehensive framework of the four dimensions 
      of medical ethics: Beneficence, Non-Maleficence, Respect, and Justice. From this 
      perspective, the ethical considerations for nanomedicine are not novel, but have 
      been addressed by precedents throughout the history of medicine. While these
      ethical challenges are not unique to nanomedicine, some require additional
      consideration, given the envisioned pervasive impact of nanomedicine on society.
CI  - (c) 2012 American Society of Law, Medicine & Ethics, Inc.
FAU - Hall, Rebecca M
AU  - Hall RM
AD  - The Methodist Hospital Research Institute, USA.
FAU - Sun, Tong
AU  - Sun T
FAU - Ferrari, Mauro
AU  - Ferrari M
LA  - eng
GR  - 1-RC1-HG005338-01/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, American Recovery and Reinvestment Act
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Beneficence
MH  - Environmental Exposure/prevention & control
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Nanomedicine/*ethics/*methods
MH  - Nanostructures/adverse effects/therapeutic use
MH  - Patient Rights/ethics
MH  - Precision Medicine/ethics/methods
MH  - Risk Management/*ethics
MH  - *Social Control, Formal
MH  - Social Justice
EDAT- 2013/01/08 06:00
MHDA- 2014/01/25 06:00
CRDT- 2013/01/08 06:00
PHST- 2013/01/08 06:00 [entrez]
PHST- 2013/01/08 06:00 [pubmed]
PHST- 2014/01/25 06:00 [medline]
AID - 10.1111/j.1748-720X.2012.00705.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2012 Winter;40(4):763-79. doi:
      10.1111/j.1748-720X.2012.00705.x.


PMID- 23289678
OWN - NLM
STAT- MEDLINE
DCOM- 20140124
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 40
IP  - 4
DP  - 2012 Winter
TI  - An empirical examination of the current state of publically available
      nanotechnology guidance materials.
PG  - 751-62
LID - 10.1111/j.1748-720X.2012.00704.x [doi]
AB  - As part of "Nanodiagnostics and Nanotherapeutics: Building Research Ethics and
      Oversight," an empirical search was conducted to identify publicly available
      resources that guided understanding about human subjects issues in nanomedicine
      or nanotechnology including policy statements, guidance documents, or consent
      forms. The authors conducted 5,083 internet searches and analyzed 175 documents. 
      Results show that very little guidance is publicly available and most documents
      focused on occupational and environmental concerns.
CI  - (c) 2012 American Society of Law, Medicine & Ethics, Inc.
FAU - Fleege, Laura
AU  - Fleege L
AD  - University of Minnesota Law School, Minneapolis, MN, USA.
FAU - Lawrenz, Frances
AU  - Lawrenz F
LA  - eng
GR  - 1-RC1-HG005338-01/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, American Recovery and Reinvestment Act
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - *Bibliometrics
MH  - Consent Forms
MH  - Environmental Exposure/*prevention & control
MH  - Guidelines as Topic
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - *Information Dissemination
MH  - Internet
MH  - Nanomedicine/ethics
MH  - Nanotechnology/*ethics
MH  - Occupational Exposure/prevention & control
MH  - Risk Assessment
MH  - *Risk Management
MH  - United States
EDAT- 2013/01/08 06:00
MHDA- 2014/01/25 06:00
CRDT- 2013/01/08 06:00
PHST- 2013/01/08 06:00 [entrez]
PHST- 2013/01/08 06:00 [pubmed]
PHST- 2014/01/25 06:00 [medline]
AID - 10.1111/j.1748-720X.2012.00704.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2012 Winter;40(4):751-62. doi:
      10.1111/j.1748-720X.2012.00704.x.


PMID- 23289677
OWN - NLM
STAT- MEDLINE
DCOM- 20140124
LR  - 20211021
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 40
IP  - 4
DP  - 2012 Winter
TI  - Recommendations for nanomedicine human subjects research oversight: an
      evolutionary approach for an emerging field.
PG  - 716-50
LID - 10.1111/j.1748-720X.2012.00703.x [doi]
AB  - The nanomedicine field is fast evolving toward complex, "active," and interactive
      formulations. Like many emerging technologies, nanomedicine raises questions of
      how human subjects research (HSR) should be conducted and the adequacy of current
      oversight, as well as how to integrate concerns over occupational, bystander, and
      environmental exposures. The history of oversight for HSR investigating emerging 
      technologies is a patchwork quilt without systematic justification of when
      ordinary oversight for HSR is enough versus when added oversight is warranted.
      Nanomedicine HSR provides an occasion to think systematically about appropriate
      oversight, especially early in the evolution of a technology, when hazard and
      risk information may remain incomplete. This paper presents the consensus
      recommendations of a multidisciplinary, NIH-funded project group, to ensure a
      science-based and ethically informed approach to HSR issues in nanomedicine, and 
      to integrate HSR analysis with analysis of occupational, bystander, and
      environmental concerns. We recommend creating two bodies, an interagency Human
      Subjects Research in Nanomedicine (HSR/N) Working Group and a Secretary's
      Advisory Committee on Nanomedicine (SAC/N). HSR/N and SAC/N should perform 3
      primary functions: (1) analysis of the attributes and subsets of nanomedicine
      interventions that raise HSR challenges and current gaps in oversight; (2)
      providing advice to relevant agencies and institutional bodies on the HSR issues,
      as well as federal and federal-institutional coordination; and (3) gathering and 
      analyzing information on HSR issues as they emerge in nanomedicine. HSR/N and
      SAC/N will create a home for HSR analysis and coordination in DHHS (the key
      agency for relevant HSR oversight), optimize federal and institutional
      approaches, and allow HSR review to evolve with greater knowledge about
      nanomedicine interventions and greater clarity about attributes of concern.
CI  - (c) 2012 American Society of Law, Medicine & Ethics, Inc.
FAU - Fatehi, Leili
AU  - Fatehi L
AD  - University of Minnesota, MN, USA.
FAU - Wolf, Susan M
AU  - Wolf SM
FAU - McCullough, Jeffrey
AU  - McCullough J
FAU - Hall, Ralph
AU  - Hall R
FAU - Lawrenz, Frances
AU  - Lawrenz F
FAU - Kahn, Jeffrey P
AU  - Kahn JP
FAU - Jones, Cortney
AU  - Jones C
FAU - Campbell, Stephen A
AU  - Campbell SA
FAU - Dresser, Rebecca S
AU  - Dresser RS
FAU - Erdman, Arthur G
AU  - Erdman AG
FAU - Haynes, Christy L
AU  - Haynes CL
FAU - Hoerr, Robert A
AU  - Hoerr RA
FAU - Hogle, Linda F
AU  - Hogle LF
FAU - Keane, Moira A
AU  - Keane MA
FAU - Khushf, George
AU  - Khushf G
FAU - King, Nancy M P
AU  - King NM
FAU - Kokkoli, Efrosini
AU  - Kokkoli E
FAU - Marchant, Gary
AU  - Marchant G
FAU - Maynard, Andrew D
AU  - Maynard AD
FAU - Philbert, Martin
AU  - Philbert M
FAU - Ramachandran, Gurumurthy
AU  - Ramachandran G
FAU - Siegel, Ronald A
AU  - Siegel RA
FAU - Wickline, Samuel
AU  - Wickline S
LA  - eng
GR  - RC1 HG005338/HG/NHGRI NIH HHS/United States
GR  - 1-RC1-HG005338-01/HG/NHGRI NIH HHS/United States
PT  - Consensus Development Conference
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Advisory Committees
MH  - Environmental Exposure/*prevention & control
MH  - *Government Regulation
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Nanomedicine/*ethics
MH  - Occupational Exposure/prevention & control
MH  - Risk Management/*organization & administration
MH  - United States
PMC - PMC4467171
MID - NIHMS697245
EDAT- 2013/01/08 06:00
MHDA- 2014/01/25 06:00
CRDT- 2013/01/08 06:00
PHST- 2013/01/08 06:00 [entrez]
PHST- 2013/01/08 06:00 [pubmed]
PHST- 2014/01/25 06:00 [medline]
AID - 10.1111/j.1748-720X.2012.00703.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2012 Winter;40(4):716-50. doi:
      10.1111/j.1748-720X.2012.00703.x.


PMID- 23287113
OWN - NLM
STAT- MEDLINE
DCOM- 20130711
LR  - 20130125
IS  - 1879-2057 (Electronic)
IS  - 0001-4575 (Linking)
VI  - 51
DP  - 2013 Mar
TI  - Modeling motivation and habit in driving behavior under lifetime driver's license
      revocation.
PG  - 260-7
LID - 10.1016/j.aap.2012.11.017 [doi]
LID - S0001-4575(12)00408-3 [pii]
AB  - The purpose of the present study was to verify the motivational factors
      underlying the theory of planned behavior (TPB) predicting the driving behavior
      of lifetime driving license revoked offenders. Of a total of 639 drivers whose
      licenses had been permanently revoked, 544 offenders completed a questionnaire
      constructed to measure attitudes toward behaviors, subjective norms, perceived
      behavioral control, behavioral intentions (the key constructs of the TPB), and
      previous driving habit strength. The finding of the study revealed that an
      offenders' driving behavior after a lifetime license revocation was significantly
      correlated to behavioral intention (R=0.60, p<0.01), perceived behavioral control
      (R=0.61, p<0.01), previous driving habit (R=0.44, p<0.01), and attitude (R=0.41, 
      p<0.01). There was no evidence that subjective norms including road regulation,
      society ethics, and people important to offenders had an influence on driving
      behavior (R=0.03). Low driving habit strength offenders are motivated to drive
      because of behavioral intention, whereas strong driving habit strength offenders 
      are motivated to drive because of perceived behavioral control. Previous driving 
      habit strength is a moderator in the intention-behavior relationship. The model
      appeared successful when previous habits were weak, but less successful when
      previous habits were strong.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Tseng, Chien-Ming
AU  - Tseng CM
AD  - Ministry of Transportation and Communications, 6 Shengfu Road, Chung-Shin
      Village, Nantou City 54045, Taiwan, ROC. tsengcm168@yahoo.com.tw
FAU - Chang, Hsin-Li
AU  - Chang HL
FAU - Woo, T Hugh
AU  - Woo TH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121231
PL  - England
TA  - Accid Anal Prev
JT  - Accident; analysis and prevention
JID - 1254476
SB  - IM
MH  - Adult
MH  - Attitude
MH  - Automobile Driving/legislation & jurisprudence/*psychology/statistics & numerical
      data
MH  - Crime/*psychology/statistics & numerical data
MH  - Female
MH  - Follow-Up Studies
MH  - *Habits
MH  - Humans
MH  - Intention
MH  - Internal-External Control
MH  - *Licensure/legislation & jurisprudence
MH  - Male
MH  - *Models, Psychological
MH  - *Motivation
MH  - Principal Component Analysis
MH  - Psychological Theory
MH  - Self Report
MH  - Taiwan
EDAT- 2013/01/05 06:00
MHDA- 2013/07/13 06:00
CRDT- 2013/01/05 06:00
PHST- 2011/03/08 00:00 [received]
PHST- 2012/11/05 00:00 [revised]
PHST- 2012/11/20 00:00 [accepted]
PHST- 2013/01/05 06:00 [entrez]
PHST- 2013/01/05 06:00 [pubmed]
PHST- 2013/07/13 06:00 [medline]
AID - S0001-4575(12)00408-3 [pii]
AID - 10.1016/j.aap.2012.11.017 [doi]
PST - ppublish
SO  - Accid Anal Prev. 2013 Mar;51:260-7. doi: 10.1016/j.aap.2012.11.017. Epub 2012 Dec
      31.


PMID- 23285907
OWN - NLM
STAT- MEDLINE
DCOM- 20130207
LR  - 20191210
IS  - 1001-5302 (Print)
IS  - 1001-5302 (Linking)
VI  - 37
IP  - 18
DP  - 2012 Sep
TI  - [Clinical outcomes research of traditional Chinese medicine--introduce registry
      intensive hospital monitoring study protocol of traditiona Chinese medicine
      injection's safety].
PG  - 2683-5
AB  - Traditional Chinese medicine (TCM) injection's safety problems has been paid
      attention for the country and people, TCM injection's labels described the
      adverse reactions always shows "unclear" or blank, especially the adverse drug
      reactions(ADR) rates hardly reported. To save the problem, large-scale safety
      surveillance of TCM injection research is very important. The article introduces 
      the research aim, research type, simple size, outcomes and ethic problem during
      make the plan. It is a multi-center, large sample size, registry research program
      about TCM injections safety monitoring. The aim is to get the ADR's rate of TCM
      injections. According to the "three rules" , each of the TCM injection will be
      observed for 30 000 cases which are inpatients. The research adopt to using the
      barcode system and hospital information system(HIS) & laboratory information
      management system(LIS) to make sure enroll all patients. Case report file (CRF)
      is used for record patient's information which contained 3 types(A, B, C) tables.
      Most of people just need to fill table A, and the patient need to fill table B
      when they have ADR. The outcome of the research is severe ADR. Abide by the
      international ethical principle to keep the patient's right.
FAU - Yang, Wei
AU  - Yang W
AD  - Institute of Basic Research in Clinical Medicine, China Academy of Chinese
      Medical Sciences, Beijing 100700, China. ywonline@163.com
FAU - Xie, Yan-Ming
AU  - Xie YM
FAU - Wang, Yong-Yan
AU  - Wang YY
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Zhong Yao Za Zhi
JT  - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese
      materia medica
JID - 8913656
RN  - 0 (Drugs, Chinese Herbal)
SB  - IM
MH  - Biomedical Research/*standards
MH  - China
MH  - Clinical Protocols/*standards
MH  - Clinical Trials as Topic
MH  - Drug Therapy/*standards
MH  - Drugs, Chinese Herbal/*administration & dosage/adverse effects
MH  - Humans
MH  - Medicine, Chinese Traditional/*standards
MH  - Outcome Assessment, Health Care/legislation & jurisprudence/*standards
EDAT- 2013/01/05 06:00
MHDA- 2013/02/08 06:00
CRDT- 2013/01/05 06:00
PHST- 2013/01/05 06:00 [entrez]
PHST- 2013/01/05 06:00 [pubmed]
PHST- 2013/02/08 06:00 [medline]
PST - ppublish
SO  - Zhongguo Zhong Yao Za Zhi. 2012 Sep;37(18):2683-5.


PMID- 23285833
OWN - NLM
STAT- MEDLINE
DCOM- 20130131
LR  - 20191027
IS  - 0037-8046 (Print)
IS  - 0037-8046 (Linking)
VI  - 57
IP  - 4
DP  - 2012 Oct
TI  - Integrating social workers into medical-legal partnerships: comprehensive problem
      solving for patients.
PG  - 333-41
AB  - Medical-legal partnerships (MLPs) integrate legal services into the health care
      setting to resolve legal issues that have a negative impact on patient health.
      These partnerships between attorneys and health care professionals have
      traditionally focused on physicians. Despite early success and expansion of the
      MLP model, the literature is only beginning to explore the significant role that 
      social workers can play in an MLP's development, process, and success. This
      article argues that MLPs are greatly enhanced when they seek the active
      engagement of a health center's social workers. All members of the MLP, however, 
      should be aware of differing ethical and legal obligations in the medical, social
      work, and legal profession as well as differences in professional cultures that
      can affect the work of the partnership.
FAU - Colvin, Jeffrey David
AU  - Colvin JD
AD  - Department of Pediatrics, Children's Mercy Hospital & Clinic, Kansas City, MO,
      USA. jdcolvin@cmh.edu
FAU - Nelson, Brooke
AU  - Nelson B
FAU - Cronin, Katie
AU  - Cronin K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Soc Work
JT  - Social work
JID - 2984852R
SB  - IM
MH  - Delivery of Health Care/ethics/*legislation & jurisprudence/organization &
      administration
MH  - Humans
MH  - *Interprofessional Relations
MH  - Lawyers
MH  - Models, Organizational
MH  - Patient Advocacy/ethics/*legislation & jurisprudence
MH  - Problem Solving
MH  - Social Problems
MH  - Social Work/ethics/*legislation & jurisprudence/organization & administration
MH  - United States
EDAT- 2013/01/05 06:00
MHDA- 2013/02/01 06:00
CRDT- 2013/01/05 06:00
PHST- 2013/01/05 06:00 [entrez]
PHST- 2013/01/05 06:00 [pubmed]
PHST- 2013/02/01 06:00 [medline]
AID - 10.1093/sw/sws012 [doi]
PST - ppublish
SO  - Soc Work. 2012 Oct;57(4):333-41. doi: 10.1093/sw/sws012.


PMID- 23285794
OWN - NLM
STAT- MEDLINE
DCOM- 20130118
LR  - 20191112
IS  - 1054-6863 (Print)
IS  - 1054-6863 (Linking)
VI  - 22
IP  - 3
DP  - 2012 Sep
TI  - The problem of fetal pain and abortion: toward an ethical consensus for
      appropriate behavior.
PG  - 263-87
AB  - Debate exists over whether fetuses feel pain, and if so what to do about it.
      Because they cannot provide self-report, certitude on the question cannot be
      reached. The essay argues that a presumption of reasonable doubt is adequate to
      inform moral behavior. It looks at the most recent evidence from fetal
      anatomical, neurochemical, physiological and behavioral research and concludes
      that a reasonable doubt exists that fetuses from 20 to 23 weeks do not feel pain.
      It proposes that where abortion is legal, providers should be legally required
      both to provide full disclosure of the possibility of fetal pain starting at 20
      weeks and to offer pain-relief measures to suppress fetal pain to all women
      seeking an abortion.
FAU - Brugger, E Christian
AU  - Brugger EC
AD  - St. John Vianney Theological Seminary, Denver, Colorado, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Kennedy Inst Ethics J
JT  - Kennedy Institute of Ethics journal
JID - 9109135
RN  - 0 (Analgesics)
RN  - 0 (Anesthetics)
SB  - IM
MH  - Abortion, Induced/adverse effects/*ethics/methods
MH  - Analgesics/administration & dosage/adverse effects
MH  - Anesthetics/administration & dosage/adverse effects
MH  - Female
MH  - *Fetus/physiology
MH  - Humans
MH  - Maternal Mortality
MH  - Morals
MH  - Pain/*etiology/*prevention & control
MH  - *Pain Perception
MH  - Pregnancy
MH  - Pregnancy Trimester, Third
MH  - United Kingdom/epidemiology
MH  - United States/epidemiology
EDAT- 2013/01/05 06:00
MHDA- 2013/01/19 06:00
CRDT- 2013/01/05 06:00
PHST- 2013/01/05 06:00 [entrez]
PHST- 2013/01/05 06:00 [pubmed]
PHST- 2013/01/19 06:00 [medline]
AID - 10.1353/ken.2012.0014 [doi]
PST - ppublish
SO  - Kennedy Inst Ethics J. 2012 Sep;22(3):263-87. doi: 10.1353/ken.2012.0014.


PMID- 23285793
OWN - NLM
STAT- MEDLINE
DCOM- 20130118
LR  - 20191112
IS  - 1054-6863 (Print)
IS  - 1054-6863 (Linking)
VI  - 22
IP  - 3
DP  - 2012 Sep
TI  - Evaluating the first-in-human clinical trial of a human embryonic stem cell-based
      therapy.
PG  - 243-61
AB  - Phase I clinical trials generally raise greater ethical and human protection
      challenges than later stage clinical trials, suggesting a need to proceed
      cautiously. This is particularly the case for Phase I trials with a novel therapy
      being tested in humans for the first time, usually termed first-in-human (FIH)
      trials. In January 2009, the Food and Drug Administration approved the
      Investigational New Drug application of Geron Corporation, a small
      California-based biopharmaceutical company, to initiate a clinical trial to
      assess GRNOPC1, a human embryonic stem cell-derived candidate therapy for severe 
      spinal cord injuries. This article evaluates the ethical and human subject
      protection issues raised by the Geron FIH trial. It identifies problems with the 
      approval process and with the conduct of the trial, and then recommends ways to
      improve review of future proposed trials with novel and high-risk therapies.
FAU - Chapman, Audrey R
AU  - Chapman AR
AD  - University of Connecticut School of Medicine, USA.
FAU - Scala, Courtney C
AU  - Scala CC
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Kennedy Inst Ethics J
JT  - Kennedy Institute of Ethics journal
JID - 9109135
SB  - IM
MH  - Animals
MH  - Clinical Trials as Topic/*ethics
MH  - Disease Models, Animal
MH  - *Embryonic Stem Cells
MH  - Humans
MH  - *Investigational New Drug Application
MH  - Oligodendroglia
MH  - Spinal Cord Injuries/drug therapy/surgery/*therapy
MH  - Stem Cell Research/*ethics
MH  - Stem Cell Transplantation/*ethics/methods
MH  - United States
MH  - United States Food and Drug Administration
EDAT- 2013/01/05 06:00
MHDA- 2013/01/19 06:00
CRDT- 2013/01/05 06:00
PHST- 2013/01/05 06:00 [entrez]
PHST- 2013/01/05 06:00 [pubmed]
PHST- 2013/01/19 06:00 [medline]
AID - 10.1353/ken.2012.0013 [doi]
PST - ppublish
SO  - Kennedy Inst Ethics J. 2012 Sep;22(3):243-61. doi: 10.1353/ken.2012.0013.


PMID- 23285792
OWN - NLM
STAT- MEDLINE
DCOM- 20130118
LR  - 20191210
IS  - 1054-6863 (Print)
IS  - 1054-6863 (Linking)
VI  - 22
IP  - 3
DP  - 2012 Sep
TI  - Where are we in the justification of research involving chimpanzees?
PG  - 211-42
AB  - On December 15, 2011, the Institute of Medicine (IOM) Committee on the Use of
      Chimpanzees in Biomedical and Behavioral Research issued a final report
      commissioned by the National Institutes of Health (NIH). It changed the landscape
      of discussion about the necessity of using chimpanzees in research. The Committee
      advanced three principles of scientifically warranted research on chimpanzees,
      but NIH's statement of task provided inadequate opportunity for the Committee to 
      investigate moral problems and their implications for public policy. The IOM
      Committee's report is a landmark document, but it has weaknesses in its
      justificatory framework, largely resulting from the Committee's narrow remit from
      NIH and IOM. We analyze cases mentioned in the report and argue that numerous
      central ethical issues are neglected, especially ones of justification.
      Additionally, we consider whether the principles offered by the Committee could
      be used as criteria governing the use of other animals in biomedical and
      behavioral research.
FAU - Beauchamp, Tom L
AU  - Beauchamp TL
AD  - Department of Philosophy, Kennedy Institute of Ethics, Georgetown University,
      Washington, DC, USA.
FAU - Ferdowsian, Hope R
AU  - Ferdowsian HR
FAU - Gluck, John P
AU  - Gluck JP
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Kennedy Inst Ethics J
JT  - Kennedy Institute of Ethics journal
JID - 9109135
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Viral Hepatitis Vaccines)
SB  - IM
MH  - Advisory Committees
MH  - Animal Experimentation/*ethics
MH  - Animals
MH  - Antibodies, Monoclonal/therapeutic use
MH  - Behavioral Research/ethics
MH  - Cooperative Behavior
MH  - Depression/etiology
MH  - Ethics, Research
MH  - Genomics
MH  - Housing, Animal/ethics/standards
MH  - Humans
MH  - *Moral Obligations
MH  - National Academies of Science, Engineering, and Medicine, U.S., Health and
      Medicine Division
MH  - National Institutes of Health (U.S.)
MH  - *Pan troglodytes/psychology
MH  - Public Policy
MH  - *Research Design
MH  - Research Personnel/ethics
MH  - Research Report
MH  - Stress Disorders, Post-Traumatic/etiology
MH  - United States
MH  - Viral Hepatitis Vaccines/administration & dosage
EDAT- 2013/01/05 06:00
MHDA- 2013/01/19 06:00
CRDT- 2013/01/05 06:00
PHST- 2013/01/05 06:00 [entrez]
PHST- 2013/01/05 06:00 [pubmed]
PHST- 2013/01/19 06:00 [medline]
AID - 10.1353/ken.2012.0012 [doi]
PST - ppublish
SO  - Kennedy Inst Ethics J. 2012 Sep;22(3):211-42. doi: 10.1353/ken.2012.0012.


PMID- 23285411
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130104
LR  - 20220321
IS  - 2074-1804 (Print)
IS  - 2074-1804 (Linking)
VI  - 14
IP  - 10
DP  - 2012 Oct
TI  - Ethical dilemmas in disaster medicine.
PG  - 602-12
AB  - BACKGROUND: Disasters may lead to ethical challenges that are different from
      usual medical practices. In addition, disaster situations are related with public
      health ethics more than medical ethics, and accordingly may require stronger
      effort to achieve a balance between individual and collective rights. This paper 
      aims to review some ethical dilemmas that arise in disasters and mainly focuses
      on health services. Disasters vary considerably with respect to their time, place
      and extent; therefore, ethical questions may not always have `one-size-fits-all` 
      answers. On the other hand, embedding ethical values and principles in every
      aspect of health-care is of vital importance. Reviewing legal and organizational 
      regulations, developing health-care related guidelines, and disaster recovery
      plans, establishing on-call ethics committees as well as adequate in-service
      training of health-care workers for ethical competence are among the most
      critical steps. It is only by making efforts before disasters, that ethical
      challenges can be minimized in disaster responses.
FAU - Ozge Karadag, C
AU  - Ozge Karadag C
AD  - Department of Public Health, Faculty of Medicine, Hacettepe University, Ankara,
      Turkey.
FAU - Kerim Hakan, A
AU  - Kerim Hakan A
LA  - eng
PT  - Journal Article
DEP - 20121030
PL  - Iran
TA  - Iran Red Crescent Med J
JT  - Iranian Red Crescent medical journal
JID - 101319850
PMC - PMC3518976
OTO - NOTNLM
OT  - Bioethics
OT  - Disaster medicine
OT  - Disasters
OT  - Ethics
OT  - Public health
EDAT- 2013/01/04 06:00
MHDA- 2013/01/04 06:01
CRDT- 2013/01/04 06:00
PHST- 2012/12/13 00:00 [received]
PHST- 2012/06/22 00:00 [accepted]
PHST- 2013/01/04 06:00 [entrez]
PHST- 2013/01/04 06:00 [pubmed]
PHST- 2013/01/04 06:01 [medline]
PST - ppublish
SO  - Iran Red Crescent Med J. 2012 Oct;14(10):602-12. Epub 2012 Oct 30.


PMID- 23284866
OWN - NLM
STAT- MEDLINE
DCOM- 20130625
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 12
DP  - 2012
TI  - Revisiting the stopping rule for hepatitis C genotype 1 patients treated with
      peginterferon plus ribavirin.
PG  - e52048
LID - 10.1371/journal.pone.0052048 [doi]
AB  - BACKGROUND: The current stopping rule for peginterferon/ribavirin therapy in
      hepatitis C virus genotype-1 (HCV-1) patients is based on an early virological
      response (EVR, defined as >2 log(10) viral reduction at treatment week 12). We
      aimed to explore rapid stopping rules at week 4. METHODS: We randomly allocated
      528 HCV-1 patients into training and validation sets (at a 1ratio2 ratio). The
      interleukin-28B rs8099917 genotypes and on-treatment virological responses were
      evaluated to determine the negative predictive value (NPV) for achieving a
      sustained virological response (SVR, defined as undetectable HCV RNA 24 weeks
      after end-of-treatment). The study was approved by the ethics committees of the
      participating hospitals. All of the patients gave written informed consent before
      enrollment. RESULTS: A poor week 4 response (W4R), defined as a HCV RNA reduction
      of <1 log(10) IU/mL at week 4 or a week 4 HCV RNA>10,000 IU/mL with
      interleukin-28B non-TT genotype, had the highest NPV (95%). In the complete
      sample, poor W4R could identify 43.4% (59/136) of the non-responders, with an NPV
      of 95% and a false negative rate of only 0.8% (3/396). The multivariate analysis 
      revealed that a poor W4R was the most important negative predictor (odds
      ratio/95% confidence intervals: 49.01/13.70-175.37), followed by the lack of an
      EVR. In addition to HCV RNA<1 log(10) IU/mL reduction, using the criteria of HCV 
      RNA>10,000 IU/mL/non-TT genotype helped identifying an additional one-third of
      non-SVR patients at W4.Using the strategy of sequential rapid stopping rule
      strategy could identify 53.7% (73/136) of the non-responders (43.4% at week 4 and
      an addition 11.3% at week 12), as compared to 40.4% for the classical week-12
      early stopping rule. CONCLUSIONS: Sequential rapid stopping rules using
      on-treatment virological responses and interleukin-28B genotype can rapidly
      identify additional peginterferon/ribavirin non-responders.
FAU - Yu, Ming-Lung
AU  - Yu ML
AD  - Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical
      University Hospital, Kaohsiung, Taiwan.
FAU - Liu, Chen-Hua
AU  - Liu CH
FAU - Huang, Chung-Feng
AU  - Huang CF
FAU - Tseng, Tai-Chung
AU  - Tseng TC
FAU - Huang, Jee-Fu
AU  - Huang JF
FAU - Dai, Chia-Yen
AU  - Dai CY
FAU - Lin, Zu-Yau
AU  - Lin ZY
FAU - Chen, Shinn-Cherng
AU  - Chen SC
FAU - Wang, Liang-Yen
AU  - Wang LY
FAU - Juo, Suh-Hang Hank
AU  - Juo SH
FAU - Chuang, Wan-Long
AU  - Chuang WL
FAU - Kao, Jia-Horng
AU  - Kao JH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121221
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (IFNL3 protein, human)
RN  - 0 (Interferon alpha-2)
RN  - 0 (Interferon-alpha)
RN  - 0 (Interleukins)
RN  - 0 (Recombinant Proteins)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 49717AWG6K (Ribavirin)
RN  - 9008-11-1 (Interferons)
RN  - G8RGG88B68 (peginterferon alfa-2b)
RN  - Q46947FE7K (peginterferon alfa-2a)
SB  - IM
MH  - Adult
MH  - Female
MH  - *Genotype
MH  - Hepacivirus/*genetics
MH  - Hepatitis C/*drug therapy/genetics/virology
MH  - Humans
MH  - Interferon alpha-2
MH  - Interferon-alpha/administration & dosage/*therapeutic use
MH  - Interferons
MH  - Interleukins/genetics
MH  - Male
MH  - Middle Aged
MH  - Polyethylene Glycols/administration & dosage/*therapeutic use
MH  - Recombinant Proteins/administration & dosage/therapeutic use
MH  - Ribavirin/administration & dosage/*therapeutic use
MH  - Time Factors
MH  - Treatment Outcome
MH  - Viral Load
PMC - PMC3528729
EDAT- 2013/01/04 06:00
MHDA- 2013/06/26 06:00
CRDT- 2013/01/04 06:00
PHST- 2012/09/14 00:00 [received]
PHST- 2012/11/08 00:00 [accepted]
PHST- 2013/01/04 06:00 [entrez]
PHST- 2013/01/04 06:00 [pubmed]
PHST- 2013/06/26 06:00 [medline]
AID - 10.1371/journal.pone.0052048 [doi]
AID - PONE-D-12-27905 [pii]
PST - ppublish
SO  - PLoS One. 2012;7(12):e52048. doi: 10.1371/journal.pone.0052048. Epub 2012 Dec 21.


PMID- 23283430
OWN - NLM
STAT- MEDLINE
DCOM- 20140424
LR  - 20130103
IS  - 0717-6287 (Electronic)
IS  - 0716-9760 (Linking)
VI  - 45
IP  - 3
DP  - 2012
TI  - Stem cells: sources and therapies.
PG  - 207-14
LID - 10.4067/S0716-97602012000300002 [doi]
LID - S0716-97602012000300002 [pii]
AB  - The historical, lexical and conceptual issues embedded in stem cell biology are
      reviewed from technical, ethical, philosophical, judicial, clinical, economic and
      biopolitical perspectives. The mechanisms assigning the simultaneous capacity to 
      self-renew and to differentiate to stem cells (immortal template DNA and
      asymmetric division) are evaluated in the light of the niche hypothesis for the
      stemness state. The induction of cell pluripotency and the different stem cells
      sources are presented (embryonic, adult and cord blood). We highlight the
      embryonic and adult stem cell properties and possible therapies while we
      emphasize the particular scientific and social values of cord blood donation to
      set up cord blood banks. The current scientific and legal frameworks of cord
      blood banks are reviewed at an international level as well as allogenic,
      dedicated and autologous donations. The expectations and the challenges in
      relation to present-day targeted diseases like diabetes mellitus type I,
      Parkinson's disease and myocardial infarction are evaluated in the light of the
      cellular therapies for regenerative medicine.
FAU - Monti, Manuela
AU  - Monti M
AD  - Center for Regenerative Medicine, San Matteo Foundation for Research,
      Hospitalization and Health Care, Pavia, Italy. m.monti@smatteo.pv.it
FAU - Perotti, Cesare
AU  - Perotti C
FAU - Del Fante, Claudia
AU  - Del Fante C
FAU - Cervio, Marila
AU  - Cervio M
FAU - Redi, Carlo Alberto
AU  - Redi CA
CN  - Fondazione IRCCS Policlinico San Matteo, Pavia (Italia)
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Biol Res
JT  - Biological research
JID - 9308271
SB  - IM
MH  - *Adult Stem Cells
MH  - *Blood Banks
MH  - *Embryonic Stem Cells
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - *Stem Cell Transplantation/ethics/history/methods
EDAT- 2013/01/04 06:00
MHDA- 2014/04/25 06:00
CRDT- 2013/01/04 06:00
PHST- 2012/06/01 00:00 [received]
PHST- 2012/06/19 00:00 [accepted]
PHST- 2013/01/04 06:00 [entrez]
PHST- 2013/01/04 06:00 [pubmed]
PHST- 2014/04/25 06:00 [medline]
AID - S0716-97602012000300002 [pii]
AID - 10.4067/S0716-97602012000300002 [doi]
PST - ppublish
SO  - Biol Res. 2012;45(3):207-14. doi: 10.4067/S0716-97602012000300002.


PMID- 23282785
OWN - NLM
STAT- MEDLINE
DCOM- 20131118
LR  - 20130103
IS  - 0717-6163 (Electronic)
IS  - 0034-9887 (Linking)
VI  - 140
IP  - 8
DP  - 2012 Aug
TI  - [Neuroethics: reflections on the latent principles of morals in medicine].
PG  - 1078-84
LID - 10.4067/S0034-98872012000800018 [doi]
LID - S0034-98872012000800018 [pii]
AB  - Ethical dilemmas resulting from neural sciences have promoted the emergence of a 
      new discipline termed neuroethics. Researchers distinguish between ethics of
      neuroscience and neuroscience of ethics. The former deals with ethical problems
      arising from new forms of interventions into the brain. The latter investigates
      the neural mechanisms that may possibly underlie morality as such. This article
      presents a survey of the new empirical facts and directions, and a critical
      evaluation of the methodological and ontological problems underlying neuroethics 
      as such. Conceptual analyses of research issues and the underlying implicit
      conceptions of human being are thoroughly investigated based on Heidegger's
      thought.
FAU - Figueroa, Gustavo
AU  - Figueroa G
AD  - Departamento de Psiquiatria, Escuela de Medicina, Universidad de Valparaiso,
      Chile. gfigueroacave@gmail.com
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Neuroetica: reflexiones sobre los principios latentes de la moral en medicina.
PL  - Chile
TA  - Rev Med Chil
JT  - Revista medica de Chile
JID - 0404312
SB  - IM
MH  - Bioethical Issues
MH  - Biotechnology/ethics
MH  - Humans
MH  - Neurosciences/*ethics
EDAT- 2013/01/04 06:00
MHDA- 2013/11/19 06:00
CRDT- 2013/01/04 06:00
PHST- 2012/02/29 00:00 [received]
PHST- 2012/05/16 00:00 [accepted]
PHST- 2013/01/04 06:00 [entrez]
PHST- 2013/01/04 06:00 [pubmed]
PHST- 2013/11/19 06:00 [medline]
AID - S0034-98872012000800018 [pii]
AID - 10.4067/S0034-98872012000800018 [doi]
PST - ppublish
SO  - Rev Med Chil. 2012 Aug;140(8):1078-84. doi: 10.4067/S0034-98872012000800018.


PMID- 23282693
OWN - NLM
STAT- MEDLINE
DCOM- 20130925
LR  - 20131112
IS  - 0717-6163 (Electronic)
IS  - 0034-9887 (Linking)
VI  - 140
IP  - 7
DP  - 2012 Jul
TI  - [Tradition and progress (1872-2012)].
PG  - 837-40
LID - 10.4067/S0034-98872012000700001 [doi]
LID - S0034-98872012000700001 [pii]
AB  - The first issue of Revista Medica de Chile appeared in July, 1872. Since then it 
      has been published monthly and thus it became one of the oldest medical journals 
      being printed since the 19th Century. The opening Editorial in the first issue,
      labeled as "Prospecto"and written by the first editor, German Schneider, M.D., is
      reproduced. The current Editors comment the main statements found in that
      document establishing the purpose and scope of this journal. There are good
      reasons to sustain that through its 140 years of life, Revista Medica de Chile
      has fully accomplished the expectations of its founders and the owning
      institution: Sociedad Medica de Santiago-Chilean Society of Internal Medicine.
      The journal is serving well the medical community as a forum to present and
      discuss clinical experience, topics in scientific and technological advances
      related to medicine, medical education, medical ethics, and public health.
FAU - Reyes B, Humberto
AU  - Reyes B H
FAU - Palma H, Joaquin
AU  - Palma H J
FAU - Andrensen H, Max
AU  - Andrensen H M
LA  - spa
PT  - Editorial
PT  - English Abstract
PT  - Historical Article
TT  - Tradicion y Progreso (1872-2012).
PL  - Chile
TA  - Rev Med Chil
JT  - Revista medica de Chile
JID - 0404312
SB  - IM
MH  - Chile
MH  - Education, Medical/*history
MH  - History, 19th Century
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Periodicals as Topic/*history
EDAT- 2013/01/04 06:00
MHDA- 2013/09/26 06:00
CRDT- 2013/01/04 06:00
PHST- 2013/01/04 06:00 [entrez]
PHST- 2013/01/04 06:00 [pubmed]
PHST- 2013/09/26 06:00 [medline]
AID - S0034-98872012000700001 [pii]
AID - 10.4067/S0034-98872012000700001 [doi]
PST - ppublish
SO  - Rev Med Chil. 2012 Jul;140(7):837-40. doi: 10.4067/S0034-98872012000700001.


PMID- 23282622
OWN - NLM
STAT- MEDLINE
DCOM- 20130731
LR  - 20131112
IS  - 0717-6163 (Electronic)
IS  - 0034-9887 (Linking)
VI  - 140
IP  - 6
DP  - 2012 Jun
TI  - [Truth telling of Alzheimer's disease diagnosis].
PG  - 811-7
LID - 10.4067/S0034-98872012000600018 [doi]
LID - S0034-98872012000600018 [pii]
AB  - Alzheimer's disease is becoming an increasingly common problem due to population 
      aging. Most of the research on truth telling in relation to diagnosis has been
      done in oncology. However, although growing, there has a lack of interest about
      attitudes held among physicians towards disclosing the diagnosis of Alzheimer's
      disease. Physicians, family caregivers and patients have different views about
      it. The reasons most often given for communicating the diagnosis are the right to
      know, relief of anxiety to know the cause of memory problems, early access to
      treatment and ability to plan ahead. On the contrary, the reasons for concealing 
      the diagnosis are based on the right not to know, the anxiety associated to
      knowing the diagnosis and the absence of curative therapies for the disease. The 
      aim of this paper is to report the current state of literature on diagnostic
      truth telling in dementia, review the ethical principles involved, and finally
      give a strategy to address the issue.
FAU - Fuentes R, Paola
AU  - Fuentes R P
AD  - Centro de Geriatria, Pontificia Universidad Catolica de Chile, Santiago, Chile.
      paolafuentesr@gmail.com
FAU - Prato, Juan Andres
AU  - Prato JA
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Comunicacion diagnostica en enfermedad de Alzheimer. Reflexion y propuesta.
PL  - Chile
TA  - Rev Med Chil
JT  - Revista medica de Chile
JID - 0404312
SB  - IM
MH  - Alzheimer Disease/*diagnosis/psychology
MH  - Attitude of Health Personnel
MH  - Attitude to Health
MH  - *Ethics, Medical
MH  - Humans
MH  - Personal Autonomy
MH  - Truth Disclosure/*ethics
EDAT- 2013/01/04 06:00
MHDA- 2013/08/01 06:00
CRDT- 2013/01/04 06:00
PHST- 2011/07/05 00:00 [received]
PHST- 2012/03/05 00:00 [accepted]
PHST- 2013/01/04 06:00 [entrez]
PHST- 2013/01/04 06:00 [pubmed]
PHST- 2013/08/01 06:00 [medline]
AID - S0034-98872012000600018 [pii]
AID - 10.4067/S0034-98872012000600018 [doi]
PST - ppublish
SO  - Rev Med Chil. 2012 Jun;140(6):811-7. doi: 10.4067/S0034-98872012000600018.


PMID- 23281952
OWN - NLM
STAT- MEDLINE
DCOM- 20130603
LR  - 20130103
IS  - 1523-536X (Electronic)
IS  - 0730-7659 (Linking)
VI  - 39
IP  - 4
DP  - 2012 Dec
TI  - Ethics and "normal birth".
PG  - 315-7
LID - 10.1111/birt.12008 [doi]
AB  - The concept of "normal birth" has been promoted as ideal by several international
      organizations, although debate about its meaning is ongoing. In this article, I
      examine the concept of normalcy to explore its ethical implications and raise a
      trio of concerns. First, in its emphasis on nonuse of technology as a goal, the
      concept of normalcy may marginalize women for whom medical intervention is
      necessary or beneficial. Second, in its emphasis on birth as a socially
      meaningful event, the mantra of normalcy may unintentionally avert attention to
      meaning in medically complicated births. Third, the emphasis on birth as a normal
      and healthy event may be a contributor to the long-standing tolerance for the
      dearth of evidence guiding the treatment of illness during pregnancy and the
      failure to responsibly and productively engage pregnant women in health research.
      Given these concerns, it is worth debating not just what "normal birth" means,
      but whether the term as an ideal earns its keep.
CI  - (c) 2012, Copyright the Authors Journal compilation (c) 2012, Wiley Periodicals, 
      Inc.
FAU - Lyerly, Anne Drapkin
AU  - Lyerly AD
AD  - Social Medicine, Chapel Hill, NC, USA.
LA  - eng
PT  - Journal Article
DEP - 20121105
PL  - United States
TA  - Birth
JT  - Birth (Berkeley, Calif.)
JID - 8302042
SB  - IM
MH  - Delivery, Obstetric/*ethics/methods
MH  - Female
MH  - Humans
MH  - Parturition/*psychology
MH  - Pregnancy
EDAT- 2013/01/04 06:00
MHDA- 2013/06/05 06:00
CRDT- 2013/01/04 06:00
PHST- 2012/07/31 00:00 [accepted]
PHST- 2013/01/04 06:00 [entrez]
PHST- 2013/01/04 06:00 [pubmed]
PHST- 2013/06/05 06:00 [medline]
AID - 10.1111/birt.12008 [doi]
PST - ppublish
SO  - Birth. 2012 Dec;39(4):315-7. doi: 10.1111/birt.12008. Epub 2012 Nov 5.


PMID- 23281856
OWN - NLM
STAT- MEDLINE
DCOM- 20130617
LR  - 20130103
IS  - 1523-536X (Electronic)
IS  - 0730-7659 (Linking)
VI  - 39
IP  - 2
DP  - 2012 Jun
TI  - Acceptability of stem cell therapy by pregnant women.
PG  - 91-7
LID - 10.1111/j.1523-536X.2012.00527.x [doi]
AB  - BACKGROUND: Cell-based therapies may soon be used to treat disorders in the
      perinatal period. Our aim was to assess pregnant women's knowledge, attitudes,
      and acceptance of different types of stem cell therapies. METHODS: Pregnant women
      attending an Australian tertiary center were asked to complete a questionnaire to
      seek their views on the potential therapeutic use of stem cells in the future.
      Outcome measures were women's acceptability of different types of stem cell
      therapies for themselves and their baby, ethical concerns, knowledge, and
      willingness to use stem cells for different indications. RESULTS: A total of 150 
      women completed the questionnaire. More women were happy to use any stem cell
      type (82%) than placental stem cells only (12.5%), adult stem cells only (2%),
      embryonic stem cells only (0), and 3.5 percent would not use. With respect to use
      for their baby, more women were happy to use any stem cell type (83%) than
      placental stem cells only (13%), embryonic stem cells only (2%), adult stem cells
      only (0), and 2 percent would not use. Ethical concerns were highest with
      embryonic stem cells (25%), than adult stem cells (11%), and placental stem cells
      (10%). Twelve percent of women were very confident and 66 percent reasonably
      confident with their knowledge, whereas 17 percent understood little and 5
      percent reported no understanding. Acceptance of using any stem cell therapy was 
      75 percent for severe medical disorders, 57 percent for moderate disorders, and
      25 percent for mild medical disorders. CONCLUSIONS: Pregnant women are confident 
      with their knowledge of stem cells and overwhelmingly support their use to treat 
      both themselves and their baby. The level of this support, however, is
      proportionate to the severity of the medical disorder. (BIRTH 39:2 June 2012).
CI  - (c) 2012, Copyright the Authors Journal compilation (c) 2012, Wiley Periodicals, 
      Inc.
FAU - Hodges, Ryan J
AU  - Hodges RJ
AD  - Department of Obstetrics & Gynaecology, Monash University, Monash Medical Centre,
      Southern Health, Clayton, Victoria, Australia.
FAU - Bardien, Nadia
AU  - Bardien N
FAU - Wallace, Euan
AU  - Wallace E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120517
PL  - United States
TA  - Birth
JT  - Birth (Berkeley, Calif.)
JID - 8302042
SB  - IM
MH  - Adult
MH  - Australia
MH  - Female
MH  - Health Behavior
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Mothers/*psychology/statistics & numerical data
MH  - Patient Acceptance of Health Care/*psychology/statistics & numerical data
MH  - Patient Satisfaction/*statistics & numerical data
MH  - Pregnancy
MH  - Pregnancy Complications/therapy
MH  - Prenatal Care/methods
MH  - Stem Cell Transplantation/*psychology/statistics & numerical data
MH  - Young Adult
EDAT- 2013/01/04 06:00
MHDA- 2013/06/19 06:00
CRDT- 2013/01/04 06:00
PHST- 2011/10/10 00:00 [accepted]
PHST- 2013/01/04 06:00 [entrez]
PHST- 2013/01/04 06:00 [pubmed]
PHST- 2013/06/19 06:00 [medline]
AID - 10.1111/j.1523-536X.2012.00527.x [doi]
PST - ppublish
SO  - Birth. 2012 Jun;39(2):91-7. doi: 10.1111/j.1523-536X.2012.00527.x. Epub 2012 May 
      17.


PMID- 23281462
OWN - NLM
STAT- MEDLINE
DCOM- 20130605
LR  - 20130102
IS  - 1999-6217 (Electronic)
IS  - 1727-5482 (Linking)
VI  - 10
IP  - 22
DP  - 2012 Sep
TI  - The Declaration of Helsinki in relation to medical research: historical and
      current perspectives.
PG  - 254-7
AB  - Medical research aims at improving diagnostic, therapeutic and prophylactic
      measures and understanding of the aetiology and pathogenesis of diseases in
      humans, and their application to improve the quality of life and survival. The
      subjects involved are exposed to hazards inherent to the experiments. In order to
      protect the human subjects and to maintain high ethical standards, the World
      Medical Association had adopted the "Declaration of Helsinki" in 1964. The aim of
      this article is to provide a comprehensive review on the historical and current
      perspectives on the Declaration of Helsinki in relation to medical research on
      human subjects.
FAU - Shrestha, B M
AU  - Shrestha BM
AD  - Sheffield Kidney Institute, Sheffield UK. shresthabm@doctors.net.uk
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Review
PL  - Nepal
TA  - J Nepal Health Res Counc
JT  - Journal of Nepal Health Research Council
JID - 101292936
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Helsinki Declaration/*history
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
EDAT- 2013/01/03 06:00
MHDA- 2013/06/06 06:00
CRDT- 2013/01/03 06:00
PHST- 2013/01/03 06:00 [entrez]
PHST- 2013/01/03 06:00 [pubmed]
PHST- 2013/06/06 06:00 [medline]
PST - ppublish
SO  - J Nepal Health Res Counc. 2012 Sep;10(22):254-7.


PMID- 23281421
OWN - NLM
STAT- MEDLINE
DCOM- 20130226
LR  - 20211021
IS  - 1532-6535 (Electronic)
IS  - 0009-9236 (Linking)
VI  - 93
IP  - 2
DP  - 2013 Feb
TI  - Inclusion of pediatric samples in an opt-out biorepository linking DNA to
      de-identified medical records: pediatric BioVU.
PG  - 204-11
LID - 10.1038/clpt.2012.230 [doi]
AB  - The Vanderbilt DNA repository, BioVU, links DNA from leftover clinical blood
      samples to de-identified electronic medical records (EMRs). After initiating
      adult sample collection, pediatric extension required consideration of ethical
      concerns specific to pediatrics and implementation of specialized DNA extraction 
      methods. In the first year of pediatric sample collection, more than 11,000
      samples from individuals younger than 18 years were included. We compared data
      from the pediatric BioVU cohort with those from the overall Vanderbilt University
      Medical Center pediatric population and found similar demographic
      characteristics; however, the BioVU cohort had higher rates of select diseases,
      medication exposures, and laboratory testing, demonstrating enriched
      representation of severe or chronic disease. The fact that the sample
      accumulation is not balanced may accelerate research in some cohorts while
      limiting the study of relatively benign conditions and the accrual of unaffected 
      and unbiased control samples. BioVU represents a feasible model for pediatric DNA
      biobanking but involves both ethical and practical considerations specific to the
      pediatric population.
FAU - McGregor, T L
AU  - McGregor TL
AD  - Department of Pediatrics, Vanderbilt University and the Monroe Carell Jr.
      Children's Hospital at Vanderbilt, Nashville, Tennessee, USA.
FAU - Van Driest, S L
AU  - Van Driest SL
FAU - Brothers, K B
AU  - Brothers KB
FAU - Bowton, E A
AU  - Bowton EA
FAU - Muglia, L J
AU  - Muglia LJ
FAU - Roden, D M
AU  - Roden DM
LA  - eng
GR  - 5U01HG004603/HG/NHGRI NIH HHS/United States
GR  - T32 GM007569/GM/NIGMS NIH HHS/United States
GR  - S10 RR027764/RR/NCRR NIH HHS/United States
GR  - U01 HG004603/HG/NHGRI NIH HHS/United States
GR  - K12 ES015855/ES/NIEHS NIH HHS/United States
GR  - U01 HG006378/HG/NHGRI NIH HHS/United States
GR  - UL1 RR024975/RR/NCRR NIH HHS/United States
GR  - 5T32 GM007569-33/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20121121
PL  - United States
TA  - Clin Pharmacol Ther
JT  - Clinical pharmacology and therapeutics
JID - 0372741
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biological Specimen Banks/*ethics/standards
MH  - Biomedical Research/*ethics/standards
MH  - Child
MH  - Child, Preschool
MH  - DNA/*blood
MH  - Databases, Nucleic Acid/*ethics/standards
MH  - Electronic Health Records/*ethics/standards
MH  - Humans
MH  - Infant
MH  - Informed Consent
MH  - Young Adult
PMC - PMC3686097
MID - NIHMS472618
EDAT- 2013/01/03 06:00
MHDA- 2013/02/27 06:00
CRDT- 2013/01/03 06:00
PHST- 2013/01/03 06:00 [entrez]
PHST- 2013/01/03 06:00 [pubmed]
PHST- 2013/02/27 06:00 [medline]
AID - clpt2012230 [pii]
AID - 10.1038/clpt.2012.230 [doi]
PST - ppublish
SO  - Clin Pharmacol Ther. 2013 Feb;93(2):204-11. doi: 10.1038/clpt.2012.230. Epub 2012
      Nov 21.


PMID- 23280487
OWN - NLM
STAT- MEDLINE
DCOM- 20130902
LR  - 20161125
IS  - 1097-0223 (Electronic)
IS  - 0197-3851 (Linking)
VI  - 33
IP  - 2
DP  - 2013 Feb
TI  - Active management of selective intrauterine growth restriction with abnormal
      Doppler in monochorionic diamniotic twin pregnancies diagnosed in the second
      trimester of pregnancy.
PG  - 109-15
LID - 10.1002/pd.4031 [doi]
AB  - OBJECTIVE: This study aims to compare outcomes of active management of
      monochorionic diamniotic twin pregnancies complicated with severe intrauterine
      growth restriction (IUGR) of one twin before 24 weeks with continuous or
      intermittent absent or reversed end-diastolic flow (AREDF) in the umbilical
      artery, with or without twin-to-twin transfusion syndrome (TTTS). METHOD: This
      study is a retrospective comparison of 45 consecutive cases of severe selective
      IUGR (s-IUGR) defined as an estimated fetal weight at or below the fifth centile 
      with a >25% weight discordance and AREDF in the umbilical artery before 24 weeks 
      and 166 consecutive cases of TTTS stage III, with AREDF in the donor (TTTS3D) and
      also with s-IUGR. These were treated by either selective laser photocoagulation
      of chorionic vessels (SLPCV) or cord coagulation (CC). RESULTS: The 166 cases of 
      TTTS3D were treated by SLPCV, whereas 23 and 22 cases of s-IUGR were treated by
      SLPCV and CC, respectively. Overall survival was 52.17% or 45.45% in s-IUGR
      treated by SLPCV or CC, respectively, and 48.49% in TTTS3D. The survival of
      appropriately grown for gestational age (AGA) twins following CC (90.9%) was
      higher than that following SLPCV in s-IUGR (74%) or in recipient twins of TTTS3D 
      (55.42%) (p = 0.001). Survival of the IUGR twin was 30% and 41.56% with SLPCV in 
      s-IUGR and TTTS3D, respectively. CONCLUSIONS: Active management of severe IUGR
      with AREDF in the umbilical artery seems beneficial. Survival rates with SLPCV
      were similar in s-IUGR and TTTS3D. However, there was a trend for higher survival
      rates in the AGA twin for CC. The choice of the technique should be driven by
      objective counseling on survival of both IUGR and AGA twins and therefore by the 
      utility-based ethical values expressed by the pregnant woman.
CI  - (c) 2012 John Wiley & Sons, Ltd.
FAU - Chalouhi, G E
AU  - Chalouhi GE
AD  - National Referral Centre for Management of Complicated Monochorionic Pregnancies,
      Department of Obstetrics and Fetal Medicine, Paris Descartes University,
      Assistance Publique-Hopitaux de Paris, Hopital Necker-Enfants-Malades, 75015,
      Paris, France.
FAU - Marangoni, M A
AU  - Marangoni MA
FAU - Quibel, T
AU  - Quibel T
FAU - Deloison, B
AU  - Deloison B
FAU - Benzina, N
AU  - Benzina N
FAU - Essaoui, M
AU  - Essaoui M
FAU - Al Ibrahim, A
AU  - Al Ibrahim A
FAU - Stirnemann, J J
AU  - Stirnemann JJ
FAU - Salomon, L J
AU  - Salomon LJ
FAU - Ville, Y
AU  - Ville Y
LA  - eng
PT  - Journal Article
DEP - 20121226
PL  - England
TA  - Prenat Diagn
JT  - Prenatal diagnosis
JID - 8106540
SB  - IM
MH  - Adult
MH  - Female
MH  - Fetal Growth Retardation/diagnostic imaging/etiology/*mortality/surgery
MH  - Fetofetal Transfusion/diagnostic imaging/*mortality/surgery
MH  - Humans
MH  - Laser Coagulation
MH  - Pregnancy
MH  - Pregnancy Trimester, Second
MH  - *Pregnancy, Twin
MH  - Retrospective Studies
MH  - Survival Rate
MH  - Twins, Monozygotic
MH  - Ultrasonography
EDAT- 2013/01/03 06:00
MHDA- 2013/09/03 06:00
CRDT- 2013/01/03 06:00
PHST- 2013/01/03 06:00 [entrez]
PHST- 2013/01/03 06:00 [pubmed]
PHST- 2013/09/03 06:00 [medline]
AID - 10.1002/pd.4031 [doi]
PST - ppublish
SO  - Prenat Diagn. 2013 Feb;33(2):109-15. doi: 10.1002/pd.4031. Epub 2012 Dec 26.


PMID- 23279655
OWN - NLM
STAT- MEDLINE
DCOM- 20131017
LR  - 20130412
IS  - 1460-9592 (Electronic)
IS  - 1155-5645 (Linking)
VI  - 23
IP  - 5
DP  - 2013 May
TI  - Revisiting the anatomy of the ilio-inguinal/iliohypogastric nerve block.
PG  - 390-4
LID - 10.1111/pan.12099 [doi]
AB  - BACKGROUND: The ilio-inguinal/iliohypogastric nerve block (INB) is one of the
      most common peripheral nerve block techniques in pediatric anesthesia, which is
      largely due to the introduction of ultrasound (US) guidance. Despite the benefits
      of US guidance, the absence of an US machine should not deter the provider from
      performing INB, considering that many institutions, especially in developing
      countries, cannot afford to provide ultrasound machines in their anesthesiology
      departments. The aim of this study was to revisit the anatomical position of the 
      ilio-inguinal and iliohypogastric nerves in relation to the anterior superior
      iliac spine (ASIS), in a large sample of neonatal cadavers, and compare the
      results with a similar group in a previously published US-guided study. METHODS: 
      With Ethics Committee approval, the ilio-inguinal and iliohypogastric nerves were
      carefully dissected in 54 neonatal cadavers. RESULTS: In the total sample, the
      ilio-inguinal nerve was found to be 2.2 +/- 1.2 mm from the ASIS, on a line
      connecting the ASIS to the umbilicus. The iliohypogastric nerve was on average
      3.8 +/- 1.3 mm from the ASIS. For the entire sample, the optimal needle insertion
      site was 3.00 mm from the ASIS. Although there is a strong correlation between
      the needle insertion point and the weight of the neonate, this will only 'fit'
      for 60% of the population. CONCLUSION: The linear regression formula; needle
      insertion distance (mm) = 0.6 x weight + 1.8 can be used as a guideline for the
      position of the ilio-inguinal and iliohypogastric nerves.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - van Schoor, Albert-Neels
AU  - van Schoor AN
AD  - Department of Anatomy, School of Medicine, Faculty of Health Sciences, University
      of Pretoria, Pretoria, South Africa. albert.vanschoor@up.ac.za
FAU - Bosman, Marius C
AU  - Bosman MC
FAU - Bosenberg, Adrian T
AU  - Bosenberg AT
LA  - eng
PT  - Journal Article
DEP - 20121229
PL  - France
TA  - Paediatr Anaesth
JT  - Paediatric anaesthesia
JID - 9206575
SB  - IM
MH  - Cadaver
MH  - Female
MH  - Humans
MH  - Hypogastric Plexus/anatomy & histology
MH  - Ilium/*anatomy & histology/innervation
MH  - Infant
MH  - Infant, Newborn
MH  - Inguinal Canal/*anatomy & histology/innervation
MH  - Linear Models
MH  - Male
MH  - Muscle, Skeletal/anatomy & histology/innervation
MH  - *Nerve Block
MH  - Peripheral Nerves/*anatomy & histology
EDAT- 2013/01/03 06:00
MHDA- 2013/10/18 06:00
CRDT- 2013/01/03 06:00
PHST- 2012/11/19 00:00 [accepted]
PHST- 2013/01/03 06:00 [entrez]
PHST- 2013/01/03 06:00 [pubmed]
PHST- 2013/10/18 06:00 [medline]
AID - 10.1111/pan.12099 [doi]
PST - ppublish
SO  - Paediatr Anaesth. 2013 May;23(5):390-4. doi: 10.1111/pan.12099. Epub 2012 Dec 29.


PMID- 23279417
OWN - NLM
STAT- MEDLINE
DCOM- 20131210
LR  - 20130102
IS  - 1600-0579 (Electronic)
IS  - 1396-5883 (Linking)
VI  - 17
IP  - 1
DP  - 2013 Feb
TI  - Development of ethical practices and social responsibility in dental education at
      the university of Chile: student and faculty perceptions.
PG  - e70-6
LID - 10.1111/j.1600-0579.2012.00767.x [doi]
AB  - BACKGROUND: The authors argue that dental curricula in Latin America are noted
      for providing highly technical and individualistic training that may fail to
      address society's problems or instil in the dentist the idea that he/she has a
      social responsibility to contribute to his/her community. OBJECTIVES: This
      study's main objectives were to determine whether the curriculum and the faculty 
      teaching practices of the School of Dentistry at the University of Chile
      contribute to its students' commitment to ethical and social responsibility.
      METHODS: This was a qualitative study that investigated the perceptions of
      sixteen subjects (eight students and eight faculty members). Data were collected 
      in thorough deep interviews. The interview process model conceptualised and
      organised the information into sets of dimensions and categories. The dimensions 
      studied were ethical commitment and social responsibility. The categories
      assessed within ethical commitment were honesty, tolerance, responsibility and
      respect. In the social responsibility dimension, the categories were solidarity, 
      teamwork and concern for and communication with the patient. Analysis of the
      textual data was performed using a method of content analysis based upon
      constructed qualitative matrices. RESULTS: Our results show that students and
      scholars alike realise that ethical commitment and a sense of social
      responsibility are not promoted in the curriculum. They do, however, recognise
      the importance of these qualities in dental practitioners. CONCLUSIONS: These
      results indicate that the current curriculum and teaching practices used in our
      School of Dentistry need to be reviewed and that programmes promoting
      professionals' commitment to their role in society need to be implemented.
CI  - (c) 2012 John Wiley & Sons A/S.
FAU - Alcota, M
AU  - Alcota M
AD  - Department of Conservative Dentistry, School of Dentistry, University of Chile,
      Santiago, Chile.
FAU - Ruiz de Gauna, P
AU  - Ruiz de Gauna P
FAU - Gonzalez, F E
AU  - Gonzalez FE
LA  - eng
PT  - Journal Article
DEP - 20120611
PL  - England
TA  - Eur J Dent Educ
JT  - European journal of dental education : official journal of the Association for
      Dental Education in Europe
JID - 9712132
MH  - Chile
MH  - *Curriculum
MH  - Education, Dental/*methods/standards
MH  - Ethics, Dental/*education
MH  - Faculty, Dental/standards
MH  - Qualitative Research
MH  - Schools, Dental/*organization & administration
MH  - *Social Responsibility
EDAT- 2013/01/03 06:00
MHDA- 2013/12/16 06:00
CRDT- 2013/01/03 06:00
PHST- 2012/05/03 00:00 [accepted]
PHST- 2013/01/03 06:00 [entrez]
PHST- 2013/01/03 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1111/j.1600-0579.2012.00767.x [doi]
PST - ppublish
SO  - Eur J Dent Educ. 2013 Feb;17(1):e70-6. doi: 10.1111/j.1600-0579.2012.00767.x.
      Epub 2012 Jun 11.


PMID- 23279367
OWN - NLM
STAT- MEDLINE
DCOM- 20141222
LR  - 20140317
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 14
IP  - 1
DP  - 2014 Apr
TI  - The ethics of engaged presence: a framework for health professionals in
      humanitarian assistance and development work.
PG  - 47-55
LID - 10.1111/dewb.12013 [doi]
AB  - In this article, we present an ethics framework for health practice in
      humanitarian and development work: the ethics of engaged presence. The ethics of 
      engaged presence framework aims to articulate in a systematic fashion approaches 
      and orientations that support the engagement of expatriate health care
      professionals in ways that align with diverse obligations and responsibilities,
      and promote respectful and effective action and relationships. Drawn from a range
      of sources, the framework provides a vocabulary and narrative structure for
      examining the moral dimensions of providing development or humanitarian health
      assistance to individuals and communities, and working with and alongside local
      and international actors. The elements also help minimize or avoid certain
      miscalculations and harms. Emphasis is placed on the shared humanity of those who
      provide and those who receive assistance, acknowledgement of limits and risks
      related to the contributions of expatriate health care professionals, and the
      importance of providing skillful and relevant assistance. These elements
      articulate a moral posture for expatriate health care professionals that
      contributes to orienting the practice of clinicians in ways that reflect respect,
      humility, and solidarity. Health care professionals whose understanding and
      actions are consistent with the ethics of engaged presence will be oriented
      toward introspection and reflective practice and toward developing, sustaining
      and promoting collaborative partnerships.
CI  - (c) 2012 John Wiley & Sons Ltd.
FAU - Hunt, Matthew R
AU  - Hunt MR
FAU - Schwartz, Lisa
AU  - Schwartz L
FAU - Sinding, Christina
AU  - Sinding C
FAU - Elit, Laurie
AU  - Elit L
LA  - eng
GR  - 200703EOG/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121221
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
SB  - IM
MH  - *Altruism
MH  - *Cooperative Behavior
MH  - Developing Countries
MH  - Foreign Medical Graduates/*ethics
MH  - Health Personnel/ethics/standards
MH  - Humans
MH  - *International Cooperation
MH  - Moral Obligations
MH  - Nurses, International/*ethics
MH  - Relief Work/*ethics
OTO - NOTNLM
OT  - Development work
OT  - Ethics
OT  - Global health
OT  - Health care professionals
OT  - Humanitarian assistance
OT  - Moral experience
OT  - Non-governmental organizations
EDAT- 2013/01/03 06:00
MHDA- 2014/12/23 06:00
CRDT- 2013/01/03 06:00
PHST- 2013/01/03 06:00 [entrez]
PHST- 2013/01/03 06:00 [pubmed]
PHST- 2014/12/23 06:00 [medline]
AID - 10.1111/dewb.12013 [doi]
PST - ppublish
SO  - Dev World Bioeth. 2014 Apr;14(1):47-55. doi: 10.1111/dewb.12013. Epub 2012 Dec
      21.


PMID- 23279324
OWN - NLM
STAT- MEDLINE
DCOM- 20151204
LR  - 20141031
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 14
IP  - 3
DP  - 2014 Dec
TI  - Alternatives of informed consent for storage and use of human biological material
      for research purposes: Brazilian regulation.
PG  - 127-31
LID - 10.1111/dewb.12012 [doi]
AB  - Informed consent is recognized as a primary ethical requirement to conduct
      research involving humans. In the investigations with the use of human biological
      material, informed consent (IC) assumes a differentiated condition on account of 
      the many future possibilities. This work presents suitable alternatives for IC
      regarding the storage and use of human biological material in research, according
      to new Brazilian regulations. Both norms - Resolution 441/11 of the National
      Health Council, approved on 12 May 2011, and Ordinance 2.201 (NATIONAL GUIDELINES
      FOR BIOREPOSITORIES AND BIOBANKS OF HUMAN BIOLOGICAL MATERIAL FOR RESEARCH
      PURPOSE) of the Brazil Ministry of Health, approved on 14 September 2011 - state 
      that the consent of subjects for the collection, storage and use of samples
      stored in Biobanks is necessarily established by means of a Free and Informed
      Consent Form (ICF). In order to obtain individual and formal statements, this
      form should contain the following two mutually exclusive options: an explanation 
      about the use of the stored material in each research study, and the need for new
      consent or the waiver thereof when the material is used for a new study. On the
      other hand, ICF suitable for Biorepositories must be exclusive and related to
      specific research. Although Brazilian and international regulations identify the 
      main aspects to be included in the IC, efforts are still necessary to improve the
      consent process, so that the document will become a bond of trust between subject
      and researcher.
CI  - (c) 2012 John Wiley & Sons Ltd.
FAU - Marodin, Gabriela
AU  - Marodin G
FAU - Franca, Paulo Henrique Condeixa de
AU  - Franca PH
FAU - Salgueiro, Jennifer Braathen
AU  - Salgueiro JB
FAU - Motta, Marcia Luz da
AU  - Motta ML
FAU - Tannous, Gyselle Saddi
AU  - Tannous GS
FAU - Lopes, Anibal Gil
AU  - Lopes AG
LA  - eng
PT  - Journal Article
DEP - 20121221
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Brazil
MH  - Confidentiality/*ethics
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Specimen Handling/*ethics
MH  - Tissue Banks/*ethics/legislation & jurisprudence/trends
OTO - NOTNLM
OT  - biomedical research
OT  - confidentiality & privacy
OT  - ethics committees
OT  - informed consent
OT  - regulatory issues
EDAT- 2013/01/03 06:00
MHDA- 2015/12/15 06:00
CRDT- 2013/01/03 06:00
PHST- 2013/01/03 06:00 [entrez]
PHST- 2013/01/03 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - 10.1111/dewb.12012 [doi]
PST - ppublish
SO  - Dev World Bioeth. 2014 Dec;14(3):127-31. doi: 10.1111/dewb.12012. Epub 2012 Dec
      21.


PMID- 23279283
OWN - NLM
STAT- MEDLINE
DCOM- 20141222
LR  - 20211021
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 14
IP  - 1
DP  - 2014 Apr
TI  - Ethical issues in field trials of genetically modified disease-resistant
      mosquitoes.
PG  - 37-46
LID - 10.1111/dewb.12011 [doi]
AB  - Mosquito-borne diseases take a tremendous toll on human populations, especially
      in developing nations. In the last decade, scientists have developed mosquitoes
      that have been genetically modified to prevent transmission of mosquito-borne
      diseases, and field trials have been conducted. Some mosquitoes have been
      rendered infertile, some have been equipped with a vaccine they transmit to
      humans, and some have been designed to resist diseases. This article focuses on
      ethical issues raised by field trials of disease-resistant, genetically modified 
      mosquitoes. Some of these issues include: protecting the public and the
      environment from harm, balancing benefits and risks, collaborating with the local
      community, avoiding exploitation, and safeguarding the rights and welfare of
      research subjects. One of the most difficult problems involves protecting the
      welfare of community members who will be impacted by the release of mosquitoes
      but who are not enrolled in the study as research subjects. To address this
      concern, field trials should take place only when the targeted disease is a
      significant public health problem in an isolated area, the benefits of the trial 
      for the community are likely to outweigh the risks, community leaders approve of 
      the trial, and there are measures in place to protect the welfare of un-enrolled 
      community members, such as informing the community about the study and offering
      free treatment to people who contract mosquito-borne diseases. Since the
      justification of any field trial depends on a careful examination of the
      scientific and ethical issues, proposed studies should be evaluated on a
      case-by-case basis.
CI  - Published 2012. This article is a US Government work and is in the public domain 
      in the USA.
FAU - Resnik, David B
AU  - Resnik DB
LA  - eng
GR  - ZIA ES102646-04/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
DEP - 20121221
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
SB  - IM
MH  - Animals
MH  - Culicidae/*genetics/parasitology
MH  - *Genetic Engineering
MH  - Humans
MH  - Informed Consent
MH  - Insect Vectors/*genetics/parasitology
MH  - Malaria/prevention & control/transmission
MH  - Plasmodium
MH  - Public Health/ethics
PMC - PMC3620724
MID - NIHMS421726
OTO - NOTNLM
OT  - environmental impacts
OT  - ethics
OT  - field trials
OT  - genetically modified mosquitoes
OT  - informed consent
OT  - malaria
OT  - public health
EDAT- 2013/01/03 06:00
MHDA- 2014/12/23 06:00
CRDT- 2013/01/03 06:00
PHST- 2013/01/03 06:00 [entrez]
PHST- 2013/01/03 06:00 [pubmed]
PHST- 2014/12/23 06:00 [medline]
AID - 10.1111/dewb.12011 [doi]
PST - ppublish
SO  - Dev World Bioeth. 2014 Apr;14(1):37-46. doi: 10.1111/dewb.12011. Epub 2012 Dec
      21.


PMID- 23279193
OWN - NLM
STAT- MEDLINE
DCOM- 20130801
LR  - 20220410
IS  - 1526-4637 (Electronic)
IS  - 1526-2375 (Linking)
VI  - 14
IP  - 1
DP  - 2013 Jan
TI  - Analgesic efficacy and safety of medical therapy alone vs combined medical
      therapy and extraoral glossopharyngeal nerve block in glossopharyngeal neuralgia.
PG  - 93-102
LID - 10.1111/pme.12001 [doi]
AB  - OBJECTIVE: The aim of this study is to compare medical therapy alone and medical 
      therapy with add on extraoral glossopharyngeal nerve block in terms of analgesic 
      efficacy and hemodynamic safety in patients with glossopharyngeal neuralgia
      (GPN). As GPN is a rare disease, our secondary targets were to review the
      demographic profile of the disease, clinical profile, and any associations with
      the disease. DESIGN: This was a randomized, prospective, active-controlled,
      parallel group study conducted from 2007 to 2009 to determine the safety and
      efficacy of extraoral glossopharyngeal nerve block in GPN and compare it with
      pharmacological intervention. After institutional ethics committee approval and
      patient's consent, GPN patients were randomly allocated into two groups. Group A 
      (N = 15) received standard medical therapy (gabapentin 300 mg, tramadol 50 mg
      TDS, methylcobalamin 500 mugm PO) and group B (N = 15) patients received
      extraoral glossopharyngeal nerve block together with standard medical therapy.
      Patients were analyzed for analgesic outcome using numerical pain scale (NPS) and
      brief pain inventory (BPI) assessing both analgesic effect and degree of
      interference in quality of life (QOL) during 3-month follow-up. They were also
      evaluated for any significant hemodynamic alterations. RESULTS: Over the
      follow-up of 90 days, the mean NPS in group A decreased from 6 +/- 2 to 3 +/- 2
      and in group B from 5 +/- 1 to 2 +/- 2. From the mean NPS scores, it can be
      interpreted that both the modalities were effective clinically in treating GPN.
      However, NPS scores were statistically similar by the end of 90 days. Improvement
      from baseline in BPI measurement of QOL (mood, interpersonal relationship, and
      emotion) was earlier in group B (1, 2, and 1 months, respectively) compared with 
      group A (2, 3, and 2 months, respectively). However, there were no significant
      hemodynamic adverse outcomes after administration of the block. CONCLUSION: This 
      study found that patients in both the groups had significantly lower pain
      intensities, improved pain relief, and reduced pain interference with QOL, which 
      was especially evident on fourth visit (2 months) after the initiation of
      treatment regimen. Both were safe and well tolerated. The study advocates
      rational polypharmacy approach (oral and block) in difficult to treat painful
      conditions. Further controlled trials are warranted to further define the impact 
      of such a combination therapy.
CI  - Wiley Periodicals, Inc.
FAU - Singh, Preet M
AU  - Singh PM
AD  - Anaesthesia and Intensive Care, All India Institute of Medical Sciences, New
      Delhi, India. preetrajpal@gmail.com
FAU - Dehran, Maya
AU  - Dehran M
FAU - Mohan, Virender K
AU  - Mohan VK
FAU - Trikha, Anjan
AU  - Trikha A
FAU - Kaur, Manpreet
AU  - Kaur M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20121228
PL  - England
TA  - Pain Med
JT  - Pain medicine (Malden, Mass.)
JID - 100894201
RN  - 0 (Analgesics)
SB  - IM
MH  - Adult
MH  - Analgesics/*administration & dosage
MH  - Combined Modality Therapy/statistics & numerical data
MH  - Drug-Related Side Effects and Adverse Reactions/*epidemiology
MH  - Female
MH  - Glossopharyngeal Nerve Diseases/*epidemiology/*prevention & control
MH  - Humans
MH  - India/epidemiology
MH  - Male
MH  - Nerve Block/*statistics & numerical data
MH  - Pain Measurement/drug effects/statistics & numerical data
MH  - Prevalence
MH  - Risk Factors
MH  - Treatment Outcome
EDAT- 2013/01/03 06:00
MHDA- 2013/08/02 06:00
CRDT- 2013/01/03 06:00
PHST- 2013/01/03 06:00 [entrez]
PHST- 2013/01/03 06:00 [pubmed]
PHST- 2013/08/02 06:00 [medline]
AID - 10.1111/pme.12001 [doi]
PST - ppublish
SO  - Pain Med. 2013 Jan;14(1):93-102. doi: 10.1111/pme.12001. Epub 2012 Dec 28.


PMID- 23279086
OWN - NLM
STAT- MEDLINE
DCOM- 20140630
LR  - 20151119
IS  - 1447-0594 (Electronic)
IS  - 1447-0594 (Linking)
VI  - 13
IP  - 4
DP  - 2013 Oct
TI  - Ethical problems in geriatrics: views of Turkish primary healthcare
      professionals.
PG  - 1059-68
LID - 10.1111/ggi.12019 [doi]
AB  - AIM: Primary healthcare professionals frequently encounter ethical issues in the 
      care of older adults. These issues might particularly appear in the context of
      "age discrimination", "respect for autonomy", "respect for privacy" and
      "decision-making competency". The aims of this study were to determine the
      frequency rates of various geriatric ethical problems and to evaluate the
      importance given to these problems in primary healthcare. METHODS: In order to
      evaluate the opinions, a questionnaire tool was formulated. The participants were
      asked to review the list of geriatric ethical issues, to state the frequency of
      encountering them and to identify the importance ratings for each issue. The
      sample consisted of 86 primary healthcare professionals (50 physicians and 36
      nurses) aged between 24 and 50 years. RESULTS: Based on the results, the most
      frequently encountered ethical issues were on "decision-making competency" and
      these issues respectively were "decision-making with relatives instead of elder
      patients", "not informing elders due to the lack of tolerance" and "not informing
      elders due to the lack of comprehending". The most important geriatric ethical
      issues were "ignoring respect for privacy", "ignoring patient's complaints" and
      "rejecting detailed examination or treatment because of age". CONCLUSION:
      Overall, the results show that the nurses and physicians in primary healthcare
      frequently encounter geriatric ethical problems related to the decision-making
      process, which is a common issue for Turkey as a paternalistic society. The
      findings show that primary healthcare professionals are sensitive to geriatric
      ethical issues; however, this sensitivity does not prevent the emergence of these
      issues.
CI  - (c) 2012 Japan Geriatrics Society.
FAU - Kadioglu, Funda Gulay
AU  - Kadioglu FG
AD  - Department of Medical Ethics, Cukurova University Faculty of Medicine, Adana,
      Turkey.
FAU - Can, Rana
AU  - Can R
FAU - Nazik, Sadik
AU  - Nazik S
FAU - Kadioglu, Selim
AU  - Kadioglu S
LA  - eng
PT  - Journal Article
DEP - 20121226
PL  - Japan
TA  - Geriatr Gerontol Int
JT  - Geriatrics & gerontology international
JID - 101135738
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Decision Making
MH  - *Ethics
MH  - *Ethics, Medical
MH  - *Ethics, Nursing
MH  - Female
MH  - Geriatrics/*ethics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Primary Health Care/*ethics
MH  - Surveys and Questionnaires
MH  - Turkey
MH  - Young Adult
OTO - NOTNLM
OT  - age discrimination
OT  - decision making competency
OT  - ethical problems
OT  - geriatrics
OT  - primary health care professionals
EDAT- 2013/01/03 06:00
MHDA- 2014/07/01 06:00
CRDT- 2013/01/03 06:00
PHST- 2012/11/09 00:00 [accepted]
PHST- 2013/01/03 06:00 [entrez]
PHST- 2013/01/03 06:00 [pubmed]
PHST- 2014/07/01 06:00 [medline]
AID - 10.1111/ggi.12019 [doi]
PST - ppublish
SO  - Geriatr Gerontol Int. 2013 Oct;13(4):1059-68. doi: 10.1111/ggi.12019. Epub 2012
      Dec 26.


PMID- 23279082
OWN - NLM
STAT- MEDLINE
DCOM- 20151221
LR  - 20211021
IS  - 1369-7625 (Electronic)
IS  - 1369-6513 (Linking)
VI  - 18
IP  - 2
DP  - 2015 Apr
TI  - 'Someone should oversee it': patient perspectives on the ethical issues arising
      with the regulation of probiotics.
PG  - 250-61
LID - 10.1111/hex.12027 [doi]
AB  - BACKGROUND: Although many probiotic products are currently available in yogurt or
      pill form in the United States (US), there is uncertainty surrounding the
      structure of regulation of these products. As more therapeutic probiotics are
      developed, changes to existing regulatory process in the United States may be
      required to meet the needs of patients and users in the population. OBJECTIVE:
      This study examined how patients with chronic gastrointestinal (GI) diseases view
      the regulation of probiotics. DESIGN: We conducted a multi-site qualitative study
      consisting of focus groups of patients with chronic gastrointestinal diseases at 
      three tertiary hospitals: at [institutions removed for blinded review]. RESULTS: 
      We conducted 22 focus groups with 136 patients with major gastrointestinal (GI)
      diseases between March and August 2009. Participants were not familiar with the
      existing regulation of probiotic products but wanted assurances of accurate
      labelling of strain as well as safety. Participants raised concerns that
      regulation of probiotics might be accompanied by greater costs, reduced access
      and increased involvement of pharmaceutical companies. Although participants
      voiced significant doubt of government regulators, they felt that products
      containing genetically modified probiotic strains should have oversight
      comparable to that of pharmaceutical drugs. DISCUSSION AND CONCLUSION: If GI
      patient perspectives are indicative of public perceptions of therapeutic
      probiotics in the United States, consumers may expect more rigorous regulation in
      the future while simultaneously wanting low costs, easy access and low
      involvement of pharmaceutical companies. Manufacturers, translational scientists,
      clinicians and regulators should be sensitive to consumer attitudes when
      designing, testing and regulating new therapeutic probiotics.
CI  - (c) 2012 John Wiley & Sons Ltd.
FAU - Harrison, Krista L
AU  - Harrison KL
AD  - Berman Institute of Bioethics, Johns Hopkins University, Baltimore, MD, USA;
      Department of Health Policy and Management, Johns Hopkins Bloomberg School of
      Public Health, Baltimore, MD, USA.
FAU - Farrell, Ruth M
AU  - Farrell RM
FAU - Brinich, Margaret A
AU  - Brinich MA
FAU - Highland, Janelle
AU  - Highland J
FAU - Mercer, MaryBeth
AU  - Mercer M
FAU - McCormick, Jennifer B
AU  - McCormick JB
FAU - Tilburt, Jon
AU  - Tilburt J
FAU - Geller, Gail
AU  - Geller G
FAU - Marshall, Patricia
AU  - Marshall P
FAU - Sharp, Richard R
AU  - Sharp RR
LA  - eng
GR  - R01 HG004877/HG/NHGRI NIH HHS/United States
GR  - R01HG004877/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
DEP - 20121228
PL  - England
TA  - Health Expect
JT  - Health expectations : an international journal of public participation in health 
      care and health policy
JID - 9815926
SB  - IM
MH  - Chronic Disease
MH  - Female
MH  - Focus Groups
MH  - Gastrointestinal Diseases/*psychology
MH  - *Government Regulation
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Male
MH  - Perception
MH  - *Probiotics
MH  - Socioeconomic Factors
MH  - Tertiary Care Centers
MH  - United States
PMC - PMC4022694
MID - NIHMS418078
OTO - NOTNLM
OT  - bioethics
OT  - government regulation
OT  - metagenome
OT  - probiotics
OT  - qualitative research
EDAT- 2013/01/03 06:00
MHDA- 2015/12/22 06:00
CRDT- 2013/01/03 06:00
PHST- 2012/10/22 00:00 [accepted]
PHST- 2013/01/03 06:00 [entrez]
PHST- 2013/01/03 06:00 [pubmed]
PHST- 2015/12/22 06:00 [medline]
AID - 10.1111/hex.12027 [doi]
PST - ppublish
SO  - Health Expect. 2015 Apr;18(2):250-61. doi: 10.1111/hex.12027. Epub 2012 Dec 28.


PMID- 23278568
OWN - NLM
STAT- MEDLINE
DCOM- 20140714
LR  - 20140103
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 28
IP  - 2
DP  - 2014 Feb
TI  - To donate a kidney: public perspectives from Pakistan.
PG  - 76-83
LID - 10.1111/bioe.12010 [doi]
AB  - Despite the majority opinion of Muslim jurists that organ donation is permitted
      in Sharia, surveys indicate continuing resistance by lay Muslims, especially to
      donating organs following death. Pakistan, a country with 165 million Muslims,
      currently reliant on live donors, is considering steps to establish deceased
      donor programs which will require public acceptance and support. This article
      analyzes the results of in-depth interviews with 105 members of the public
      focusing on opinions and knowledge about juristic rulings regarding kidney
      donations, donor-family dynamics in deceased donation decisions, and attitudes
      towards buying kidneys. The objective was to determine the influence if any of
      cultural and religious values, and norms of traditional family structures and
      kinships, on decisions to donate. Study participants view donation of kidneys,
      particularly from the deceased, through a different lens from that used by
      jurists and physicians, one that also does not conform to familiar paradigms
      defining ethical organ donation. A socially modulated understanding of Islam
      passed down the generations, and longstanding family-centric norms, shape the
      moral worldview of many rather than academic juristic rulings or non-contextual
      concepts of autonomy and rights. The results of this study also highlight that
      medical science may be universal but its application occurs within
      particularities of cultural and religious values, social constructs of the self
      and its relationship with others, and different ways in which humans comprehend
      illness, suffering, and death. These findings are of relevance both to transplant
      related professionals and bioethicists involved with this field.
CI  - (c) 2012 John Wiley & Sons Ltd.
FAU - Moazam, Farhat
AU  - Moazam F
FAU - Jafarey, Aamir M
AU  - Jafarey AM
FAU - Shirazi, Bushra
AU  - Shirazi B
LA  - eng
PT  - Journal Article
DEP - 20121221
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Adult
MH  - *Attitude
MH  - *Culture
MH  - Data Collection
MH  - Death
MH  - Family
MH  - Female
MH  - Humans
MH  - Interviews as Topic
MH  - *Islam
MH  - Kidney
MH  - Male
MH  - Middle Aged
MH  - *Morals
MH  - Pakistan
MH  - *Public Opinion
MH  - Religion and Medicine
MH  - *Tissue Donors
MH  - *Tissue and Organ Procurement/ethics
MH  - Young Adult
OTO - NOTNLM
OT  - Muslims and kidney donation
OT  - Sharia and transplantation
OT  - organ donation
EDAT- 2013/01/03 06:00
MHDA- 2014/07/16 06:00
CRDT- 2013/01/03 06:00
PHST- 2013/01/03 06:00 [entrez]
PHST- 2013/01/03 06:00 [pubmed]
PHST- 2014/07/16 06:00 [medline]
AID - 10.1111/bioe.12010 [doi]
PST - ppublish
SO  - Bioethics. 2014 Feb;28(2):76-83. doi: 10.1111/bioe.12010. Epub 2012 Dec 21.


PMID- 23278523
OWN - NLM
STAT- MEDLINE
DCOM- 20151002
LR  - 20140915
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 28
IP  - 8
DP  - 2014 Oct
TI  - A framework to link international clinical research to the promotion of justice
      in global health.
PG  - 387-96
LID - 10.1111/bioe.12009 [doi]
AB  - How international research might contribute to justice in global health has not
      been substantively addressed by bioethics. Theories of justice from political
      philosophy establish obligations for parties from high-income countries owed to
      parties from low and middle-income countries. We have developed a new framework
      that is based on Jennifer Ruger's health capability paradigm to strengthen the
      link between international clinical research and justice in global health. The
      'research for health justice' framework provides direction on three aspects of
      international clinical research: the research target, research capacity
      strengthening, and post-trial benefits. It identifies the obligations of justice 
      owed by national governments, research funders, research sponsors, and
      investigators to trial participants and host communities. These obligations vary 
      from those currently articulated in international research ethics guidelines.
      Ethical requirements of a different kind are needed if international clinical
      research is to advance global health equity.
CI  - (c) 2012 John Wiley & Sons Ltd.
FAU - Pratt, Bridget
AU  - Pratt B
FAU - Loff, Bebe
AU  - Loff B
LA  - eng
PT  - Journal Article
DEP - 20121220
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Clinical Trials as Topic/economics/*ethics/standards/trends
MH  - Community-Based Participatory Research/economics/*ethics/standards
MH  - Developed Countries
MH  - Developing Countries
MH  - Ethics, Research
MH  - *Global Health/economics/ethics/standards/trends
MH  - Guidelines as Topic/standards
MH  - Health Services Accessibility/economics/*ethics
MH  - Humans
MH  - *International Cooperation
MH  - *Moral Obligations
MH  - Research Support as Topic/ethics
MH  - *Social Justice/ethics
MH  - *Social Responsibility
OTO - NOTNLM
OT  - global health
OT  - global justice
OT  - health capability paradigm
OT  - international clinical research
OT  - research ethics
EDAT- 2013/01/03 06:00
MHDA- 2015/10/03 06:00
CRDT- 2013/01/03 06:00
PHST- 2013/01/03 06:00 [entrez]
PHST- 2013/01/03 06:00 [pubmed]
PHST- 2015/10/03 06:00 [medline]
AID - 10.1111/bioe.12009 [doi]
PST - ppublish
SO  - Bioethics. 2014 Oct;28(8):387-96. doi: 10.1111/bioe.12009. Epub 2012 Dec 20.


PMID- 23278420
OWN - NLM
STAT- MEDLINE
DCOM- 20131230
LR  - 20171116
IS  - 1745-3062 (Electronic)
IS  - 1745-3054 (Linking)
VI  - 35
IP  - 4
DP  - 2012 Dec
TI  - A review of current clinical photography guidelines in relation to smartphone
      publishing of medical images.
PG  - 188-92
LID - 10.3109/17453054.2012.747174 [doi]
AB  - The rise in popularity of smartphones has seen a surge in the number of
      smartphone-specific software applications (apps) available. Among these apps,
      many are medical and healthcare related, of benefit to both the general public
      and healthcare staff. With this improved technology comes the ability to display 
      full-colour images and videos, for which medical images could be utilised. We
      reviewed current clinical photography guidelines in relation to the publishing of
      medical images in smartphone apps. Of the 5 relevant guidelines, none discussed
      hand-held electronic media or smartphone app publishing. This creates confusion
      for clinicians as to how to interpret current guidelines for this purpose.
      Medical illustrators, clinicians and NHS Trusts need to be aware of the changes
      in technology and the ethical considerations of allowing medical images to be
      published within smartphones. We discuss the issues surrounding consent and
      provide practical tips for obtaining informed consent from patients to publish
      medical images in smartphone apps.
FAU - Payne, Karl F B
AU  - Payne KF
AD  - King's College Hospital, Denmark, London, UK. karlpayne@nhs.net
FAU - Tahim, Arpan
AU  - Tahim A
FAU - Goodson, Alexander M C
AU  - Goodson AM
FAU - Delaney, Margaret
AU  - Delaney M
FAU - Fan, Kathleen
AU  - Fan K
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Vis Commun Med
JT  - Journal of visual communication in medicine
JID - 101254059
SB  - IM
MH  - *Cell Phone
MH  - *Guidelines as Topic
MH  - Humans
MH  - *Minicomputers
MH  - Photography/*standards
MH  - Publishing/*standards
EDAT- 2013/01/03 06:00
MHDA- 2014/01/01 06:00
CRDT- 2013/01/03 06:00
PHST- 2013/01/03 06:00 [entrez]
PHST- 2013/01/03 06:00 [pubmed]
PHST- 2014/01/01 06:00 [medline]
AID - 10.3109/17453054.2012.747174 [doi]
PST - ppublish
SO  - J Vis Commun Med. 2012 Dec;35(4):188-92. doi: 10.3109/17453054.2012.747174.


PMID- 23278317
OWN - NLM
STAT- MEDLINE
DCOM- 20140424
LR  - 20130916
IS  - 1467-9566 (Electronic)
IS  - 0141-9889 (Linking)
VI  - 35
IP  - 7
DP  - 2013 Sep
TI  - The 'window of opportunity' for death after severe brain injury: family
      experiences.
PG  - 1095-112
LID - 10.1111/1467-9566.12020 [doi]
AB  - This article builds on and develops the emerging bioethics literature on the
      'window of opportunity' for allowing death by withholding or withdrawing
      treatment. Our findings are drawn from in-depth interviews with 26 people (from
      14 different families) with severely brain injured relatives. These interviews
      were specifically selected from a larger study on the basis of interviewees'
      reports that their relatives would not have wanted to be kept alive in their
      current condition (e.g. in vegetative or minimally conscious states). Our
      analysis tracks the decision-making processes that have led to the situation in
      which life-sustaining treatments continue to be delivered to these
      patients--maintaining them in a state that some families describe as a 'fate
      worse than death'. We show how the medico-legal 'window of opportunity' for
      allowing the patient to die structures family experience and fails to deliver
      optimal outcomes for patients. We end with some suggestions for change.
CI  - (c) 2012 The Authors. Sociology of Health & Illness (c) 2012 Foundation for the
      Sociology of Health & Illness/JohnWiley & Sons Ltd. Published by John Wiley &
      Sons Ltd.
FAU - Kitzinger, Jenny
AU  - Kitzinger J
AD  - School of Journalism, Media and Cultural Studies, Cardiff University Department
      of Sociology, University of York.
FAU - Kitzinger, Celia
AU  - Kitzinger C
LA  - eng
GR  - 097829/Z/11/A/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121220
PL  - England
TA  - Sociol Health Illn
JT  - Sociology of health & illness
JID - 8205036
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Attitude to Death
MH  - *Brain Death
MH  - Decision Making
MH  - England
MH  - Family/*psychology
MH  - Female
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Middle Aged
MH  - Time Factors
MH  - Withholding Treatment/*ethics
OTO - NOTNLM
OT  - brain injury
OT  - death
OT  - ethics
OT  - minimally concious
OT  - vegetative
OT  - window of opportunity
EDAT- 2013/01/03 06:00
MHDA- 2014/04/25 06:00
CRDT- 2013/01/03 06:00
PHST- 2013/01/03 06:00 [entrez]
PHST- 2013/01/03 06:00 [pubmed]
PHST- 2014/04/25 06:00 [medline]
AID - 10.1111/1467-9566.12020 [doi]
PST - ppublish
SO  - Sociol Health Illn. 2013 Sep;35(7):1095-112. doi: 10.1111/1467-9566.12020. Epub
      2012 Dec 20.


PMID- 23278168
OWN - NLM
STAT- MEDLINE
DCOM- 20140314
LR  - 20211203
IS  - 1365-2648 (Electronic)
IS  - 0309-2402 (Linking)
VI  - 69
IP  - 9
DP  - 2013 Sep
TI  - Perspectives on the use of and service needs of cancer preventive services for
      ethnic minorities in Hong Kong: a study protocol.
PG  - 2116-22
LID - 10.1111/jan.12067 [doi]
AB  - AIM: To report a study protocol to explore the experience of cancer screening
      from the perspective of ethnic minorities in Hong Kong BACKGROUND: Cancer is a
      major health problem, but screening can be effective in decreasing the incidence 
      and mortality rates. Providing information on how to participate in recommended
      preventive measures and on accessibility to these services is a crucial step in
      promoting healthy behaviour. Ethnic minorities in Western countries are found to 
      be less likely to use preventive services and encounter more barriers in doing so
      than the general population. DESIGN: A mixed-method design with two phases has
      been chosen to meet the aims and objectives of the study, with Phase 1 using a
      self-reported survey and Phase 2 involving focus-group interviews. METHOD: A
      convenience sample of 1540 South Asians (770 in each gender) will be recruited
      from community centres for the Phase 1 survey in 2013-2014, of whom 72-96 will be
      invited to participate in the Phase 2 interviews. The Survey and Behavioural
      Research Ethics Committee of the local university approved the study in March
      2012. DISCUSSION: The findings will provide detailed information on the use of
      cancer screening and the barriers that this minority population faces in Hong
      Kong. The findings will inform the government and policy-makers on the
      implementation of culture-specific interventions, so as to increase the screening
      uptake rate of this ethnic minority.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - So, Winnie K W
AU  - So WK
AD  - Nethersole School of Nursing, The Chinese University of Hong Kong, Hong Kong SAR,
      China. winnieso@cuhk.edu.hk
FAU - Chan, Carmen W H
AU  - Chan CW
FAU - Choi, Kai-Chow
AU  - Choi KC
FAU - Chan, Dorothy N S
AU  - Chan DN
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121219
PL  - England
TA  - J Adv Nurs
JT  - Journal of advanced nursing
JID - 7609811
SB  - IM
MH  - *Ethnicity
MH  - Focus Groups
MH  - Hong Kong
MH  - Humans
MH  - *Minority Groups
MH  - Neoplasms/ethnology/*prevention & control
OTO - NOTNLM
OT  - cancer
OT  - ethnic minority
OT  - nursing
OT  - preventive service
OT  - protocol
OT  - screening
EDAT- 2013/01/03 06:00
MHDA- 2014/03/15 06:00
CRDT- 2013/01/03 06:00
PHST- 2012/11/17 00:00 [accepted]
PHST- 2013/01/03 06:00 [entrez]
PHST- 2013/01/03 06:00 [pubmed]
PHST- 2014/03/15 06:00 [medline]
AID - 10.1111/jan.12067 [doi]
PST - ppublish
SO  - J Adv Nurs. 2013 Sep;69(9):2116-22. doi: 10.1111/jan.12067. Epub 2012 Dec 19.


PMID- 23277773
OWN - NLM
STAT- MEDLINE
DCOM- 20130701
LR  - 20211021
IS  - 1935-469X (Electronic)
IS  - 1554-7477 (Linking)
VI  - 8
IP  - 5
DP  - 2012 Sep
TI  - Ethics of ongoing cancer care for patients making risky decisions.
PG  - e111-3
LID - 10.1200/JOP.2012.000622 [doi]
AB  - Patients who decline conventional cancer therapy yet seek to continue follow-up
      while pursuing alternative therapy can pose an ethical challenge. The potential
      benefits and harms of an ongoing clinical relationship need be assessed on a
      case-by-case basis. Ongoing efforts at communicating, understanding the patient's
      basis for decision making, and seeking to negotiate evidence-based care that is
      respectful of the patient's preferences may improve outcomes.13 However, respect 
      for the patient's autonomy does not require support for inappropriate care and
      should not require that the oncologist check his or her professional judgment at 
      the door.
FAU - Peppercorn, Jeffrey
AU  - Peppercorn J
AD  - Duke University Medical Center, Durham, NC 27710, USA.
      jeffrey.peppercorn@duke.edu
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20120626
PL  - United States
TA  - J Oncol Pract
JT  - Journal of oncology practice
JID - 101261852
SB  - IM
MH  - Adult
MH  - Breast Neoplasms/*psychology/*therapy
MH  - Complementary Therapies/ethics
MH  - *Decision Making
MH  - *Ethics, Medical
MH  - Female
MH  - Humans
MH  - Medical Oncology/*ethics
PMC - PMC3439236
EDAT- 2013/01/02 06:00
MHDA- 2013/07/03 06:00
CRDT- 2013/01/02 06:00
PHST- 2012/04/10 00:00 [accepted]
PHST- 2013/01/02 06:00 [entrez]
PHST- 2013/01/02 06:00 [pubmed]
PHST- 2013/07/03 06:00 [medline]
AID - 10.1200/JOP.2012.000622 [doi]
AID - 3778152 [pii]
PST - ppublish
SO  - J Oncol Pract. 2012 Sep;8(5):e111-3. doi: 10.1200/JOP.2012.000622. Epub 2012 Jun 
      26.


PMID- 23277639
OWN - NLM
STAT- MEDLINE
DCOM- 20130211
LR  - 20211021
IS  - 0008-5286 (Print)
IS  - 0008-5286 (Linking)
VI  - 53
IP  - 7
DP  - 2012 Jul
TI  - An ethicist's commentary on whether the rich should be allowed to get discounts
      on veterinary services for adopted animals.
PG  - 707
FAU - Rollin, Bernard E
AU  - Rollin BE
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Vet J
JT  - The Canadian veterinary journal = La revue veterinaire canadienne
JID - 0004653
SB  - IM
MH  - Animals
MH  - Canada
MH  - *Ethics, Professional
MH  - Fees and Charges/*ethics
MH  - Humans
MH  - *Income
MH  - Veterinary Medicine/*economics/*ethics
PMC - PMC3377454
EDAT- 2013/01/02 06:00
MHDA- 2013/02/12 06:00
CRDT- 2013/01/02 06:00
PHST- 2013/01/02 06:00 [entrez]
PHST- 2013/01/02 06:00 [pubmed]
PHST- 2013/02/12 06:00 [medline]
PST - ppublish
SO  - Can Vet J. 2012 Jul;53(7):707.


PMID- 23276904
OWN - NLM
STAT- MEDLINE
DCOM- 20130926
LR  - 20220309
IS  - 1549-9642 (Electronic)
IS  - 1549-9634 (Linking)
VI  - 9
IP  - 3
DP  - 2013 Apr
TI  - Dual-use nanoresearch of concern: recognizing threat and safeguarding the power
      of nanobiomedical research advances in the wake of the H5N1 controversy.
PG  - 316-21
LID - 10.1016/j.nano.2012.12.001 [doi]
LID - S1549-9634(12)00755-1 [pii]
AB  - The issue of dual-use leapt to the attention of the broader research community in
      2012, when papers detailing the changes that allow H5N1 (avian) influenza virus
      to be transmitted between mammals were published after months of controversy.
      Although there is little overlap between nanomedical research and the organisms, 
      toxins, and aims recognized by governing bodies as "of concern," dual-use
      potential is increasing along with the rapid pace of advances in nanotechnology
      and other converging technologies (biotechnology, information technology, and
      cognitive science) that introduce novel capabilities to the global community. The
      capacity for harmful misuse of research enabled by converging technology progress
      is evident in molecular manipulation of virulence factors and directed traversal 
      of the blood-brain barrier by nanoparticles. Increased awareness on the part of
      nanobiomedical scientists about dual-use potential will serve the interest of
      public health and safety as well as the integrity of the research enterprise.
      FROM THE CLINICAL EDITOR: The recent controversy about publishing vs. withholding
      a paper about the successful manipulation of H5N1 (avian) flu to be transmitted
      between mammals triggered this thought provoking "Perspective" article. Given the
      possibility of misusing medical research results for the purposes of
      bioterrorism, the ideas, moral and ethical dilemmas presented in this paper
      should be considered by every practicing clinician-scientist.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Eggleson, Kathleen
AU  - Eggleson K
AD  - University of Notre Dame, Center for Nano Science and Technology, Notre Dame,
      Indiana, USA. keggleso@nd.edu
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121229
PL  - United States
TA  - Nanomedicine
JT  - Nanomedicine : nanotechnology, biology, and medicine
JID - 101233142
RN  - 0 (Biological Warfare Agents)
SB  - IM
MH  - Animals
MH  - Biological Warfare Agents
MH  - Biomedical Research/*methods
MH  - Blood-Brain Barrier/pathology/ultrastructure
MH  - Humans
MH  - Influenza A Virus, H5N1 Subtype/growth &
      development/pathogenicity/*physiology/ultrastructure
MH  - Nanomedicine/*methods
MH  - Security Measures
MH  - Virulence
EDAT- 2013/01/02 06:00
MHDA- 2013/09/27 06:00
CRDT- 2013/01/02 06:00
PHST- 2012/10/09 00:00 [received]
PHST- 2012/11/15 00:00 [revised]
PHST- 2012/12/05 00:00 [accepted]
PHST- 2013/01/02 06:00 [entrez]
PHST- 2013/01/02 06:00 [pubmed]
PHST- 2013/09/27 06:00 [medline]
AID - S1549-9634(12)00755-1 [pii]
AID - 10.1016/j.nano.2012.12.001 [doi]
PST - ppublish
SO  - Nanomedicine. 2013 Apr;9(3):316-21. doi: 10.1016/j.nano.2012.12.001. Epub 2012
      Dec 29.


PMID- 23276655
OWN - NLM
STAT- MEDLINE
DCOM- 20130906
LR  - 20211021
IS  - 1472-6491 (Electronic)
IS  - 1472-6483 (Linking)
VI  - 26
IP  - 2
DP  - 2013 Feb
TI  - Views of internists towards uses of PGD.
PG  - 142-7
LID - 10.1016/j.rbmo.2012.11.006 [doi]
LID - S1472-6483(12)00690-6 [pii]
AB  - Preimplantation genetic diagnosis (PGD) is increasingly available, but how
      physicians view it is unclear. Internists are gatekeepers and sources of
      information, often treating disorders for which PGD is possible. This
      quantitative study surveyed 220 US internists, who were found to be divided. Many
      would recommend PGD for cystic fibrosis (CF; 33.7%), breast cancer (BRCA; 23.4%),
      familial adenomatous polyposis (FAP; 20.6%) and familial hypertrophic
      cardiomyopathy (19.9%), but few for social sex selection (5.2%); however, in each
      case, >50% were unsure. Of those surveyed, 4.9% have suggested PGD to patients.
      Only 7.1% felt qualified to answer patient questions about it. Internists who
      would refer for PGD had completed medical training less recently and, for CF,
      were more likely to have privately insured patients (P<0.033) and patients who
      reported genetic discrimination (P<0.013). Physicians more likely to refer for
      BRCA and FAP were less likely to have patients ask about genetic testing. This
      study suggests that internists often feel they have insufficient knowledge about 
      it and may refer for PGD based on limited understanding. They view possible uses 
      of PGD differently, partly reflecting varying ages of onset and disease
      treatability. These data have critical implications for training, research and
      practice. Preimplantation genetic diagnosis (PGD) allows embryos to be screened
      prior to transfer to a woman's womb for various genetic markers. This procedure
      raises complex medical, social, psychological and ethical issues, but how
      physicians view it is unclear. Internists are gatekeepers and sources of
      information, often treating disorders for which PGD use is possible. We surveyed 
      220 US internists, who were found to be divided: many would recommend PGD for
      cystic fibrosis (CF; 33.7%), breast cancer (BRCA; 23.4%), familial adenomatous
      polyposis (FAP; 20.6%), and familial hypertrophic cardiomyopathy (FHC; 19.9%) and
      a few for sex selection (5.2%); but in each case, >50% were unsure. Of those
      surveyed, 4.9% have suggested PGD to patients. Only 7.1% felt qualified to answer
      patient questions. Internists who would refer for PGD completed medical training 
      less recently and, for CF, were more likely to have privately insured patients
      and patients who reported genetic discrimination. Physicians more likely to refer
      for BRCA and FAP were less likely to have patients ask about genetic testing.
      This quantitative study suggests that internists often feel they have
      insufficient knowledge and may refer for PGD based on limited understanding. They
      view possible uses of PGD differently, partly reflecting varying ages of onset
      and disease treatability. Internists should be made aware of the potential
      benefit of PGD, but also be taught to refer patients, when appropriate, to
      clinical geneticists who could then refer the patient to an IVF/PGD team. These
      data thus have critical implications for training, research and practice.
CI  - Copyright (c) 2012 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All
      rights reserved.
FAU - Klitzman, Robert
AU  - Klitzman R
AD  - Columbia University, 1051 Riverside Drive, Mail Unit 15, New York, NY 10032, USA.
      rlk2@columbia.edu
FAU - Chung, Wendy
AU  - Chung W
FAU - Marder, Karen
AU  - Marder K
FAU - Shanmugham, Anita
AU  - Shanmugham A
FAU - Chin, Lisa J
AU  - Chin LJ
FAU - Stark, Meredith
AU  - Stark M
FAU - Leu, Cheng-Shiun
AU  - Leu CS
FAU - Appelbaum, Paul S
AU  - Appelbaum PS
LA  - eng
GR  - P30 MH043520/MH/NIMH NIH HHS/United States
GR  - UL1 RR024156/RR/NCRR NIH HHS/United States
GR  - 1P20HG005535-01/HG/NHGRI NIH HHS/United States
GR  - R-01-HG002431-01/HG/NHGRI NIH HHS/United States
GR  - R01 HG002431/HG/NHGRI NIH HHS/United States
GR  - P20 HG005535/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20121121
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
SB  - IM
MH  - Adult
MH  - Aged
MH  - Attitude of Health Personnel
MH  - Female
MH  - Genetic Testing
MH  - Humans
MH  - Infant, Newborn
MH  - *Internal Medicine
MH  - Male
MH  - Middle Aged
MH  - Pregnancy
MH  - Preimplantation Diagnosis/psychology/*statistics & numerical data
MH  - Referral and Consultation
MH  - Surveys and Questionnaires
MH  - United States
MH  - Young Adult
PMC - PMC3565017
MID - NIHMS423311
EDAT- 2013/01/02 06:00
MHDA- 2013/09/07 06:00
CRDT- 2013/01/02 06:00
PHST- 2012/08/07 00:00 [received]
PHST- 2012/11/03 00:00 [revised]
PHST- 2012/11/06 00:00 [accepted]
PHST- 2013/01/02 06:00 [entrez]
PHST- 2013/01/02 06:00 [pubmed]
PHST- 2013/09/07 06:00 [medline]
AID - S1472-6483(12)00690-6 [pii]
AID - 10.1016/j.rbmo.2012.11.006 [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2013 Feb;26(2):142-7. doi: 10.1016/j.rbmo.2012.11.006. Epub
      2012 Nov 21.


PMID- 23276058
OWN - NLM
STAT- MEDLINE
DCOM- 20130122
LR  - 20151119
IS  - 0952-6862 (Print)
IS  - 0952-6862 (Linking)
VI  - 25
IP  - 7
DP  - 2012
TI  - Accountability in the Bangladeshi accountability in healthcare privatized
      healthcare sector.
PG  - 625-44
AB  - PURPOSE: The purpose of this paper is to examine the perceived Bangladesh
      privatized healthcare sector accountability gap. DESIGN/METHODOLOGY/APPROACH:
      Data were collected from 533 patients using services in 45 Dhaka city privatized 
      hospitals. A questionnaire was designed based on 60 patient focus study group and
      the literature. FINDINGS: Structural equation modeling provides a comprehensive
      picture that allows healthcare constructs and accountability to be tested. The
      goodness-of-fit statistics supported the four factors of professionals,
      administration and management, legal enforcement, ethics and government, which
      were significantly associated with accountability. Despite Bangladeshi privatized
      healthcare growth, the study revealed that accountability mainly depends on
      government initiatives and effectively implementing existing laws. RESEARCH
      LIMITATIONS/IMPLICATIONS: The study covered one Bangladesh city (Dhaka) owing to 
      resource constraints. Qualitative methods may have enriched the findings.
      PRACTICAL IMPLICATIONS: The accountability dimensions may be applicable to other 
      countries to examine the perceived accountability gap. The study looked at the
      current Bangladesh privatized healthcare sector. Major issues of Bangladesh
      privatized healthcare accountability are discussed and recommendations for
      policymakers are suggested to improve the current circumstances.
      ORIGINALITY/VALUE: The study is the first of its kind to examine accountability
      among privatized healthcare providers in developing countries. Patients'
      accountability views require urgent attention from policy makers.
FAU - Nurunnabi, Mohammad
AU  - Nurunnabi M
AD  - Business School, Edge Hill University, Ormskirk, UK.
      Mohammad.Nurunnabi@edgehill.ac.uk
FAU - Islam, Syed Kamrul
AU  - Islam SK
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Health Care Qual Assur
JT  - International journal of health care quality assurance
JID - 8916799
MH  - Bangladesh
MH  - Factor Analysis, Statistical
MH  - Female
MH  - Focus Groups
MH  - Health Care Sector/organization & administration/*standards
MH  - Hospitals, Private/organization & administration/*standards
MH  - Humans
MH  - Male
MH  - Patient Satisfaction/*statistics & numerical data
MH  - Private Sector/standards
MH  - *Social Responsibility
MH  - Surveys and Questionnaires
EDAT- 2013/01/02 06:00
MHDA- 2013/01/23 06:00
CRDT- 2013/01/02 06:00
PHST- 2013/01/02 06:00 [entrez]
PHST- 2013/01/02 06:00 [pubmed]
PHST- 2013/01/23 06:00 [medline]
AID - 10.1108/09526861211261226 [doi]
PST - ppublish
SO  - Int J Health Care Qual Assur. 2012;25(7):625-44. doi: 10.1108/09526861211261226.


PMID- 23275469
OWN - NLM
STAT- MEDLINE
DCOM- 20140714
LR  - 20131016
IS  - 1553-3514 (Electronic)
IS  - 1553-3506 (Linking)
VI  - 20
IP  - 5
DP  - 2013 Oct
TI  - An experimental study to evaluate the Fluobeam 800 imaging system for
      fluorescence-guided lymphatic imaging and sentinel node biopsy.
PG  - 516-23
LID - 10.1177/1553350612468962 [doi]
AB  - BACKGROUND: Visualization of the lymphatic system is challenging. Lymphatic
      imaging is a crucial diagnostic tool for benign and malignant lymphatic
      pathologies. Fluorescence-guided imaging allows selective lymphatic mapping and
      sentinel lymph node (SLN) identification. There are a few fluorescence systems,
      but some drawbacks remain due to technical and ergonomic aspects. The aim of this
      study was to evaluate the feasibility of the new Fluobeam 800 imaging system.
      METHODS: After approval by the ethics committee, the system was evaluated for
      lymphography and SLN biopsy in an animal model. Five pigs each with 4 lymph node 
      (LN) stations (n = 20 LN stations) were subjected to lymphatic imaging using
      indocyanine green (ICG). Additionally, the use of ICG was compared with ICG
      adsorbed to human serum albumin (ICG-HSA). Lymphatic vessels and SLN
      identification rates were measured. RESULTS: After injection, a clear
      fluorescence signal of the lymphatic vessels was visualized leading to the LN
      station. Overall, ICG fluorescence imaging identified a mean of 2.0 lymphatic
      vessels and 1.1 (range = 1-2) SLN in 20 of 20 LN stations. Reverse lymphography
      was feasible. A clinical difference in resolution was not detected between use of
      ICG-HSA and ICG. CONCLUSION: This is the first study analyzing the feasibility of
      the Fluobeam 800 imaging system allowing transcutaneous real-time imaging. It
      enables detection of the SLN by fluorescence retention with increased detection
      depth and resolution. After fixation to the ceiling, the ergonomics advanced for 
      simultaneous field navigation and dissection. The new system can be applied for
      lymphatic imaging for lympatico-reconstructive surgery and SLN biopsy.
FAU - Hirche, Christoph
AU  - Hirche C
AD  - 1Trauma Centre Ludwigshafen, Ludwigshafen, Germany.
FAU - Engel, Holger
AU  - Engel H
FAU - Kolios, Leila
AU  - Kolios L
FAU - Cognie, Juliette
AU  - Cognie J
FAU - Hunerbein, Michael
AU  - Hunerbein M
FAU - Lehnhardt, Marcus
AU  - Lehnhardt M
FAU - Kremer, Thomas
AU  - Kremer T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121227
PL  - United States
TA  - Surg Innov
JT  - Surgical innovation
JID - 101233809
RN  - IX6J1063HV (Indocyanine Green)
SB  - IM
MH  - Animals
MH  - Female
MH  - Image-Guided Biopsy/*instrumentation/methods
MH  - Indocyanine Green/chemistry
MH  - Lymph Nodes/anatomy & histology/*chemistry/*pathology
MH  - Lymphography
MH  - Optical Imaging/*instrumentation/methods
MH  - Sentinel Lymph Node Biopsy/*instrumentation/methods
MH  - Swine
OTO - NOTNLM
OT  - ICG
OT  - fluorescence
OT  - indocyanine green
OT  - lymph node
OT  - lymphatic imaging
OT  - lymphedema
OT  - sentinel lymph node biopsy
OT  - solid tumors
EDAT- 2013/01/01 06:00
MHDA- 2014/07/16 06:00
CRDT- 2013/01/01 06:00
PHST- 2013/01/01 06:00 [entrez]
PHST- 2013/01/01 06:00 [pubmed]
PHST- 2014/07/16 06:00 [medline]
AID - 1553350612468962 [pii]
AID - 10.1177/1553350612468962 [doi]
PST - ppublish
SO  - Surg Innov. 2013 Oct;20(5):516-23. doi: 10.1177/1553350612468962. Epub 2012 Dec
      27.


PMID- 23275457
OWN - NLM
STAT- MEDLINE
DCOM- 20130923
LR  - 20130617
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 20
IP  - 4
DP  - 2013 Jun
TI  - Caring ethics and a Somali reproductive dilemma.
PG  - 366-81
LID - 10.1177/0969733012453363 [doi]
AB  - The use of traditional ethical methodologies is inadequate in addressing a
      constructed maternal-fetal rights conflict in a multicultural obstetrical
      setting. The use of caring ethics and a relational approach is better suited to
      address multicultural conceptualizations of autonomy and moral distress. The way 
      power differentials, authoritative knowledge, and informed consent are
      intertwined in this dilemma will be illuminated by contrasting traditional
      bioethics and a caring ethics approach. Cultural safety is suggested as a way to 
      develop a relational ontology. Using caring ethics and a relational approach can 
      alleviate moral distress in health-care providers, while promoting collaboration 
      and trust between providers and their patients and ultimately decreasing
      reproductive disparities. This article examines how a relational approach can be 
      applied to a cross-cultural reproductive dilemma.
FAU - Narruhn, Robin
AU  - Narruhn R
AD  - School of Nursing, Box: 357260, Rm/Bldg: T-310, Health Sciences, University of
      Washington, 1959 Pacific Street, Seattle, WA 98195, USA.
      rnarruhn@u.washington.edu
FAU - Schellenberg, Ingra R
AU  - Schellenberg IR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121228
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Cultural Competency
MH  - Delivery of Health Care/ethics
MH  - Humans
MH  - Maternal Health Services/*ethics
MH  - Nursing Care/*ethics
MH  - Patient Rights
MH  - Professional-Patient Relations/*ethics
MH  - Somalia
MH  - Transcultural Nursing/*ethics
OTO - NOTNLM
OT  - Autonomy
OT  - caring ethics
OT  - cultural safety
OT  - fetal-maternal conflict
OT  - moral distress
OT  - patient-centered care relational ethics
EDAT- 2013/01/01 06:00
MHDA- 2013/09/24 06:00
CRDT- 2013/01/01 06:00
PHST- 2013/01/01 06:00 [entrez]
PHST- 2013/01/01 06:00 [pubmed]
PHST- 2013/09/24 06:00 [medline]
AID - 0969733012453363 [pii]
AID - 10.1177/0969733012453363 [doi]
PST - ppublish
SO  - Nurs Ethics. 2013 Jun;20(4):366-81. doi: 10.1177/0969733012453363. Epub 2012 Dec 
      28.


PMID- 23275279
OWN - NLM
STAT- MEDLINE
DCOM- 20130524
LR  - 20220330
IS  - 1735-9694 (Electronic)
IS  - 0044-6025 (Linking)
VI  - 50
IP  - 10
DP  - 2012
TI  - How far do we observe publication ethics and decorum?
PG  - 655-6
FAU - Khan, Zahid Hussain
AU  - Khan ZH
LA  - eng
PT  - Editorial
PL  - Iran
TA  - Acta Med Iran
JT  - Acta medica Iranica
JID - 14540050R
SB  - IM
MH  - Congresses as Topic
MH  - Faculty, Medical
MH  - Humans
MH  - *Plagiarism
MH  - Publishing/*ethics
MH  - *Scientific Misconduct
EDAT- 2013/01/01 06:00
MHDA- 2013/05/28 06:00
CRDT- 2013/01/01 06:00
PHST- 2013/01/01 06:00 [entrez]
PHST- 2013/01/01 06:00 [pubmed]
PHST- 2013/05/28 06:00 [medline]
AID - 22700 [pii]
PST - ppublish
SO  - Acta Med Iran. 2012;50(10):655-6.


PMID- 23275174
OWN - NLM
STAT- MEDLINE
DCOM- 20131111
LR  - 20211021
IS  - 1559-1182 (Electronic)
IS  - 0893-7648 (Linking)
VI  - 47
IP  - 3
DP  - 2013 Jun
TI  - Repairing neural injuries using human umbilical cord blood.
PG  - 938-45
LID - 10.1007/s12035-012-8388-0 [doi]
AB  - Stem cells are promising sources for repairing damaged neurons and glial cells in
      neural injuries and for replacing dead cells in neurodegenerative diseases. An
      essential step for stem cell-based therapy is to generate large quantities of
      stem cells and develop reliable culture conditions to direct efficient
      differentiation of specific neuronal and glial subtypes. The human umbilical cord
      and umbilical cord blood (UCB) are rich sources of multiple stem cells, including
      hematopoietic stem cells, mesenchymal stem cells, unrestricted somatic stem
      cells, and embryonic-like stem cells. Human UC/UCB-derived cells are able to give
      rise to multiple cell types of neural lineages. Studies have shown that UCB and
      UCB-derived cells can survive in injured sites in animal models of ischemic brain
      damage and spinal cord injuries, and promote survival and prevent cell death of
      local neurons and glia. Human UCB is easy to harvest and purify. Moreover, unlike
      embryonic stem cells, the use of human UCB is not limited by ethical quandaries. 
      Therefore, human UCB is an attractive source of stem cells for repairing neural
      injuries.
FAU - Sun, Tao
AU  - Sun T
AD  - Department of Cell and Developmental Biology, Weill Medical College of Cornell
      University, 1300 York Avenue, Box 60, New York, NY 10065, USA.
      tas2009@med.cornell.edu
FAU - Ma, Quan-Hong
AU  - Ma QH
LA  - eng
GR  - R01 MH083680/MH/NIMH NIH HHS/United States
GR  - R01-MH083680/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20121230
PL  - United States
TA  - Mol Neurobiol
JT  - Molecular neurobiology
JID - 8900963
SB  - IM
MH  - Animals
MH  - Fetal Blood/*cytology
MH  - Humans
MH  - *Nerve Regeneration
MH  - Neurons/*pathology
MH  - *Stem Cell Transplantation
MH  - Stem Cells/cytology
PMC - PMC3622826
MID - NIHMS432024
EDAT- 2013/01/01 06:00
MHDA- 2013/11/12 06:00
CRDT- 2013/01/01 06:00
PHST- 2012/10/12 00:00 [received]
PHST- 2012/12/13 00:00 [accepted]
PHST- 2013/01/01 06:00 [entrez]
PHST- 2013/01/01 06:00 [pubmed]
PHST- 2013/11/12 06:00 [medline]
AID - 10.1007/s12035-012-8388-0 [doi]
PST - ppublish
SO  - Mol Neurobiol. 2013 Jun;47(3):938-45. doi: 10.1007/s12035-012-8388-0. Epub 2012
      Dec 30.


PMID- 23274862
OWN - NLM
STAT- MEDLINE
DCOM- 20130610
LR  - 20121231
IS  - 1559-0879 (Electronic)
IS  - 1556-9845 (Linking)
VI  - 7
IP  - 5
DP  - 2012 Sep-Oct
TI  - Ethics: the dark side of surgical innovation.
PG  - 307-13
LID - 10.1097/IMI.0b013e3182772a2e [doi]
FAU - Knight, John L
AU  - Knight JL
AD  - Department of Cardiothoracic Surgery, Flinders Medical Centre, Bedford Park,
      Australia. john.knight@flinders.edu.au
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Innovations (Phila)
JT  - Innovations (Philadelphia, Pa.)
JID - 101257528
SB  - IM
MH  - Humans
MH  - Inventions/*ethics
MH  - Surgical Procedures, Operative/*ethics
EDAT- 2013/01/01 06:00
MHDA- 2013/06/12 06:00
CRDT- 2013/01/01 06:00
PHST- 2013/01/01 06:00 [entrez]
PHST- 2013/01/01 06:00 [pubmed]
PHST- 2013/06/12 06:00 [medline]
AID - 10.1097/IMI.0b013e3182772a2e [doi]
AID - 01243895-201210000-00001 [pii]
PST - ppublish
SO  - Innovations (Phila). 2012 Sep-Oct;7(5):307-13. doi: 10.1097/IMI.0b013e3182772a2e.


PMID- 23274847
OWN - NLM
STAT- MEDLINE
DCOM- 20130917
LR  - 20140325
IS  - 1872-8308 (Electronic)
IS  - 0376-6357 (Linking)
VI  - 94
DP  - 2013 Mar
TI  - Sunk cost and work ethic effects reflect suboptimal choice between different work
      requirements.
PG  - 55-9
LID - 10.1016/j.beproc.2012.12.003 [doi]
LID - S0376-6357(12)00269-0 [pii]
AB  - We investigated suboptimal choice between different work requirements in pigeons 
      (Columba livia), namely the sunk cost effect, an irrational tendency to persist
      with an initial investment, despite the availability of a better option. Pigeons 
      chose between two keys, one with a fixed work requirement to food of 20 pecks
      (left key), and the other with a work requirement to food which varied across
      conditions (center key). On some trials within each session, such choices were
      preceded by an investment of 35 pecks on the center key, whereas on others they
      were not. On choice trials preceded by the investment, the pigeons tended to stay
      and complete the schedule associated with the center key, even when the number of
      pecks to obtain reward was greater than for the concurrently available left key. 
      This result indicates that pigeons, like humans, commit the sunk cost effect.
      With higher work requirements, this preference was extended to trials where there
      was no initial investment, so an overall preference for the key associated with
      more work was evident, consistent with the work ethic effect. We conclude that a 
      more general work ethic effect is amplified by the effect of the prior
      investment, that is, the sunk cost effect.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Magalhaes, Paula
AU  - Magalhaes P
AD  - Department of Psychology, University of Otago, New Zealand.
      pmagalhaes@psy.otago.ac.nz
FAU - White, K Geoffrey
AU  - White KG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121227
PL  - Netherlands
TA  - Behav Processes
JT  - Behavioural processes
JID - 7703854
SB  - IM
MH  - Animals
MH  - Area Under Curve
MH  - *Behavior, Animal
MH  - *Choice Behavior
MH  - *Columbidae
MH  - *Decision Making
MH  - *Models, Animal
MH  - *Reward
MH  - Work/*psychology
EDAT- 2013/01/01 06:00
MHDA- 2013/09/18 06:00
CRDT- 2013/01/01 06:00
PHST- 2012/10/13 00:00 [received]
PHST- 2012/11/30 00:00 [revised]
PHST- 2012/12/19 00:00 [accepted]
PHST- 2013/01/01 06:00 [entrez]
PHST- 2013/01/01 06:00 [pubmed]
PHST- 2013/09/18 06:00 [medline]
AID - S0376-6357(12)00269-0 [pii]
AID - 10.1016/j.beproc.2012.12.003 [doi]
PST - ppublish
SO  - Behav Processes. 2013 Mar;94:55-9. doi: 10.1016/j.beproc.2012.12.003. Epub 2012
      Dec 27.


PMID- 23274790
OWN - NLM
STAT- MEDLINE
DCOM- 20140110
LR  - 20151119
IS  - 1432-0711 (Electronic)
IS  - 0932-0067 (Linking)
VI  - 287
IP  - 6
DP  - 2013 Jun
TI  - Prevalence and risk factors for female sexual dysfunction among Egyptian women.
PG  - 1173-80
LID - 10.1007/s00404-012-2677-8 [doi]
AB  - PURPOSE: To assess sexual function among married women and determine associated
      risk factors for sexual dysfunction. PARTICIPANTS AND METHOD: Cross-sectional
      hospital-based study involving 509 non-pregnant married females 20-59 years old
      who were enrolled into the study after approval of the ethics committee. The
      study population was recruited among women attending gynecology outpatient clinic
      or their relatives visiting inpatients of obstetrics and gynecology department at
      Suez Canal University Hospital. Female and male partner-related data were
      collected using an interview questionnaire. Sexual dysfunction was assessed using
      female sexual function index (FSFI). RESULTS: Mean female age was 39.5 years.
      About half of the participants were premenopausal (48.7 %). Most of the females
      were circumcised (71.7 %). Desire and Orgasm domains were the most affected with 
      52.8 % of the participants having sexual dysfunction. Total FSFI score of
      </=26.55 was the cutoff value for diagnosis of FSD and female age, postmenopausal
      status, duration of marriage, circumcision, partner's age, and the presence of
      male sexual dysfunction were found to be significant associated factors with FSD.
      CONCLUSION: FSD is highly prevalent in Egypt and orgasm and desire scores were
      the most affected domains. Several personal (female age, postmenopausal status,
      duration of marriage and circumcision) and male partner (age, and the presence of
      sexual dysfunction) factors were significantly associated.
FAU - Ibrahim, Zakia Mahdy
AU  - Ibrahim ZM
AD  - Department of Obstetrics and Gynecology, Faculty of Medicine, Suez Canal
      University, Round Road, Ismailia 41111, Egypt.
FAU - Ahmed, Magdy Refaat
AU  - Ahmed MR
FAU - Sayed Ahmed, Waleed Ali
AU  - Sayed Ahmed WA
LA  - eng
PT  - Journal Article
DEP - 20121230
PL  - Germany
TA  - Arch Gynecol Obstet
JT  - Archives of gynecology and obstetrics
JID - 8710213
SB  - IM
MH  - Adult
MH  - Circumcision, Female/adverse effects
MH  - Cross-Sectional Studies
MH  - Egypt/epidemiology
MH  - Erectile Dysfunction
MH  - Estrogen Replacement Therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Marital Status
MH  - Marriage
MH  - Middle Aged
MH  - Orgasm
MH  - Postmenopause
MH  - Premature Ejaculation
MH  - Risk Factors
MH  - Sexual Dysfunction, Physiological/*epidemiology
MH  - Sexual Dysfunctions, Psychological/*epidemiology
MH  - Surveys and Questionnaires
EDAT- 2013/01/01 06:00
MHDA- 2014/01/11 06:00
CRDT- 2013/01/01 06:00
PHST- 2012/08/03 00:00 [received]
PHST- 2012/12/05 00:00 [accepted]
PHST- 2013/01/01 06:00 [entrez]
PHST- 2013/01/01 06:00 [pubmed]
PHST- 2014/01/11 06:00 [medline]
AID - 10.1007/s00404-012-2677-8 [doi]
PST - ppublish
SO  - Arch Gynecol Obstet. 2013 Jun;287(6):1173-80. doi: 10.1007/s00404-012-2677-8.
      Epub 2012 Dec 30.


PMID- 23274775
OWN - NLM
STAT- MEDLINE
DCOM- 20140818
LR  - 20140103
IS  - 1573-6792 (Electronic)
IS  - 0896-0267 (Linking)
VI  - 27
IP  - 1
DP  - 2014 Jan
TI  - Neuromodulation in the service of moral enhancement.
PG  - 63-71
LID - 10.1007/s10548-012-0273-7 [doi]
AB  - Human enhancement is a much debated topic in the bioethical literature. Human
      beings have long tried to improve their capacities and their performances through
      training and with the aid of tools; but more recently new means have come to the 
      fore, such as drugs and biotechnological devices, especially in the domain of
      bodily strength and cognitive powers. Moral enhancement has been more seldom
      discussed. However, this question has recently been hotly debated between two
      philosophers, Thomas Douglas and John Harris. Douglas claims that modulating
      certain ugly emotions directly would consist in moral progress-directly, that is,
      without using cognitive means like persuasion or deliberation. Harris makes three
      objections against this thesis: such a direct neuromodulation would be
      inefficacious, would put our liberty in jeopardy and would lead to a moral
      decline. In this paper, I examine the third argument: with direct modulation, we 
      risk intervening too much or too little, inducing an inappropriate emotion or an 
      inappropriate level of an otherwise appropriate emotion-two upshots that will put
      morality in jeopardy. I conclude that the validity of this objection depends on
      several meta-ethical positions: if you are a rationalist or think that
      intentionality and consciousness are at the core of morality, you will agree with
      Harris, but if you are a sentimentalist or someone for whom results count, you
      will disagree. Here as elsewhere, ethical questions cannot be divorced from
      meta-ethical ones.
FAU - Baertschi, Bernard
AU  - Baertschi B
AD  - Institute for Biomedical Ethics, University of Geneva, Geneva, Switzerland,
      Bernard.Baertschi@unige.ch.
LA  - eng
PT  - Journal Article
DEP - 20121229
PL  - United States
TA  - Brain Topogr
JT  - Brain topography
JID - 8903034
SB  - IM
MH  - *Cognition
MH  - *Emotions
MH  - Humans
MH  - *Morals
EDAT- 2013/01/01 06:00
MHDA- 2014/08/19 06:00
CRDT- 2013/01/01 06:00
PHST- 2012/11/19 00:00 [received]
PHST- 2012/12/20 00:00 [accepted]
PHST- 2013/01/01 06:00 [entrez]
PHST- 2013/01/01 06:00 [pubmed]
PHST- 2014/08/19 06:00 [medline]
AID - 10.1007/s10548-012-0273-7 [doi]
PST - ppublish
SO  - Brain Topogr. 2014 Jan;27(1):63-71. doi: 10.1007/s10548-012-0273-7. Epub 2012 Dec
      29.


PMID- 23274675
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130101
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 6
DP  - 2012
TI  - Identifying clinical criteria to predict Type 1 diabetes, as defined by absolute 
      insulin deficiency: a systematic review protocol.
LID - 10.1136/bmjopen-2012-002309 [doi]
LID - e002309 [pii]
AB  - INTRODUCTION: Management of a patient's diabetes is entirely dependent upon the
      type of diabetes they are deemed to have. Patients with Type 1 diabetes are
      insulin deficient so require multiple daily insulin injections, whereas patients 
      with Type 2 diabetes still have some endogenous insulin production so insulin
      treatment is only required when diet and tablets do not establish good glycaemic 
      control. Despite the importance of a correct diagnosis, classification of
      diabetes is based on aetiology and relies on clinical judgement. There are no
      clinical guidelines on how to determine whether a patient has Type 1 or Type 2
      diabetes. We aim to systematically review the literature to derive evidence-based
      clinical criteria for the classification of the major subtypes of diabetes.
      METHODS AND ANALYSIS: We will perform a systematic review of diagnostic accuracy 
      studies to establish clinical criteria that predict the subsequent development of
      absolute insulin deficiency seen in Type 1 diabetes. Insulin deficiency will be
      determined by reference standard C-peptide concentrations. Synthesis of criteria 
      identified will be undertaken using hierarchical summary receiver operating
      characteristic curves. ETHICS AND DISSEMINATION: As this is a systematic review, 
      there will be no ethical issues. We will disseminate results by writing up the
      final systematic review and synthesis for publication in a peer-reviewed journal 
      and will present at national and international diabetes-related meetings.
FAU - Shields, Beverley M
AU  - Shields BM
AD  - NIHR Exeter Clinical Research Facility, University of Exeter Medical School,
      University of Exeter, Exeter, UK.
FAU - Peters, Jaime L
AU  - Peters JL
FAU - Cooper, Chris
AU  - Cooper C
FAU - Powell, Roy J
AU  - Powell RJ
FAU - Knight, Bridget A
AU  - Knight BA
FAU - Hyde, Christopher
AU  - Hyde C
FAU - Hattersley, Andrew T
AU  - Hattersley AT
LA  - eng
GR  - PB-PG-0711-25111/DH_/Department of Health/United Kingdom
PT  - Journal Article
DEP - 20121228
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC4399143
EDAT- 2013/01/01 06:00
MHDA- 2013/01/01 06:01
CRDT- 2013/01/01 06:00
PHST- 2013/01/01 06:00 [entrez]
PHST- 2013/01/01 06:00 [pubmed]
PHST- 2013/01/01 06:01 [medline]
AID - bmjopen-2012-002309 [pii]
AID - 10.1136/bmjopen-2012-002309 [doi]
PST - epublish
SO  - BMJ Open. 2012 Dec 28;2(6). pii: bmjopen-2012-002309. doi:
      10.1136/bmjopen-2012-002309. Print 2012.


PMID- 23274332
OWN - NLM
STAT- MEDLINE
DCOM- 20130528
LR  - 20190608
IS  - 2329-0358 (Electronic)
IS  - 1425-9524 (Linking)
VI  - 17
IP  - 4
DP  - 2012 Dec 31
TI  - The value of living donor liver transplantation.
PG  - 120-4
AB  - Living donor liver transplantation (LDLT) is a very successful procedure that
      develops liver resources in case of worldwide shortages. As the technology has
      developed so much in the past 2 decades, LDLT has the same good prognosis as
      DDLT. However, LDLT still has lots of ethical & technical problems. It causes
      great psychiatric, physical and psychosocial harm to donors. Also, it has some
      negative effects on society by providing a platform for organ trade. Therefore,
      there is much controversy about the social value of LDLT. After review of recent 
      papers, we find much progress can be made in inspiring the public to become organ
      donors and creating donation model new to improve the consent rate for solid
      organ donation from deceased donors. That is the key strategy for increasing the 
      liver supply. With this serious shortage of organs, liver donor transplantation
      still has its advantages, but we should not place all our hopes on LDLT to
      increase the liver supply. We all need to try our best to increase donor
      awareness and promote organ donor registration--when cadaver organs could meet
      the needs for liver transplantation, living donor liver transplants would not be 
      necessary.
FAU - Yang, Xiaoli
AU  - Yang X
AD  - Department of Hepatobiliary Surgery, Second Affiliated Hospital of Chongqing
      Medical College, Yuzhong District, Chongqing, China.
FAU - Gong, Junhua
AU  - Gong J
FAU - Gong, JianPing
AU  - Gong J
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Ann Transplant
JT  - Annals of transplantation
JID - 9802544
SB  - IM
MH  - Hepatectomy/psychology
MH  - Humans
MH  - Liver Transplantation/ethics/*methods
MH  - *Living Donors/education/ethics/psychology/supply & distribution
MH  - Postoperative Complications
MH  - *Tissue and Organ Procurement/ethics/methods/organization & administration
EDAT- 2013/01/01 06:00
MHDA- 2013/05/29 06:00
CRDT- 2013/01/01 06:00
PHST- 2013/01/01 06:00 [entrez]
PHST- 2013/01/01 06:00 [pubmed]
PHST- 2013/05/29 06:00 [medline]
AID - 883702 [pii]
AID - 10.12659/aot.883702 [doi]
PST - ppublish
SO  - Ann Transplant. 2012 Dec 31;17(4):120-4. doi: 10.12659/aot.883702.


PMID- 23273855
OWN - NLM
STAT- MEDLINE
DCOM- 20130822
LR  - 20220317
IS  - 1538-9375 (Electronic)
IS  - 1525-8610 (Linking)
VI  - 14
IP  - 2
DP  - 2013 Feb
TI  - Impact of a decision aid on surrogate decision-makers' perceptions of feeding
      options for patients with dementia.
PG  - 114-8
LID - 10.1016/j.jamda.2012.10.011 [doi]
LID - S1525-8610(12)00400-8 [pii]
AB  - OBJECTIVES: In advanced dementia, feeding problems are nearly universal, and
      families face difficult decisions about feeding options. Initial interviews for a
      randomized trial were used to describe surrogates' perceptions of feeding
      options, and to determine whether a decision aid on feeding options in advanced
      dementia would improve knowledge, reduce expectation of benefit from tube
      feeding, and reduce conflict over treatment choices for persons with advanced
      dementia. DESIGN: Semistructured interview with prestudy and poststudy design for
      surrogates in the intervention group. SETTING: Twenty-four skilled nursing
      facilities across North Carolina participating in a cluster randomized trial.
      PARTICIPANTS: Two hundred and fifty-five surrogate decision makers for nursing
      home residents with advanced dementia and feeding problems, in control (n = 129) 
      and intervention (n = 126) groups. INTERVENTION: For intervention surrogates
      only, an audiovisual-print decision aid provided information on dementia, feeding
      problems in dementia, advantages and disadvantages of feeding tubes or assisted
      oral feeding options, and the role of surrogates in making these decisions.
      MEASUREMENTS: The interview included open-ended items asking surrogates to report
      advantages and disadvantages of tube feeding and assisted oral feeding. Knowledge
      of feeding options was measured with 19 true/false items and items measuring
      expectation of benefit from tube feeding. Surrogates reported which of these two 
      feeding options they preferred for the person with dementia, and how confident
      they were in this choice; their level of conflict about the choice was measured
      using the decisional conflict scale. RESULTS: Before the decision aid, surrogates
      described advantages and disadvantages of assisted oral feeding and tube feeding 
      in practical, ethical, and medical terms. After review of the decision aid,
      intervention surrogates had improved knowledge scores (15.5 vs 16.8; P < .001),
      decreased expectation of benefits from tube feeding (2.73 vs 2.32; P = .001), and
      reduced decisional conflict (2.24 vs 1.91; P < .001). Surrogates preferred
      assisted oral feeding initially and reported more certainty about this choice
      after the decision aid. CONCLUSIONS: A structured decision aid can be used to
      improve decision making about feeding options in dementia care.
CI  - Copyright (c) 2013 American Medical Directors Association, Inc. Published by
      Elsevier Inc. All rights reserved.
FAU - Snyder, E Amanda
AU  - Snyder EA
AD  - Division of Geriatric Medicine and Center for Aging and Health, School of
      Medicine, University of North Carolina, Chapel Hill, NC 27759, USA.
FAU - Caprio, Anthony J
AU  - Caprio AJ
FAU - Wessell, Kathryn
AU  - Wessell K
FAU - Lin, Feng Chang
AU  - Lin FC
FAU - Hanson, Laura C
AU  - Hanson LC
LA  - eng
GR  - R01 AG037483/AG/NIA NIH HHS/United States
GR  - R01 NR009826/NR/NINR NIH HHS/United States
GR  - T35 AG038047/AG/NIA NIH HHS/United States
GR  - T35AG038047/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
DEP - 20121228
PL  - United States
TA  - J Am Med Dir Assoc
JT  - Journal of the American Medical Directors Association
JID - 100893243
SB  - IM
MH  - Decision Making
MH  - *Decision Support Techniques
MH  - Dementia/*physiopathology
MH  - Feeding and Eating Disorders/*physiopathology/*prevention & control
MH  - Female
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Middle Aged
MH  - North Carolina
MH  - *Third-Party Consent
PMC - PMC3563876
MID - NIHMS417476
EDAT- 2013/01/01 06:00
MHDA- 2013/08/24 06:00
CRDT- 2013/01/01 06:00
PHST- 2012/08/16 00:00 [received]
PHST- 2012/10/14 00:00 [revised]
PHST- 2012/10/19 00:00 [accepted]
PHST- 2013/01/01 06:00 [entrez]
PHST- 2013/01/01 06:00 [pubmed]
PHST- 2013/08/24 06:00 [medline]
AID - S1525-8610(12)00400-8 [pii]
AID - 10.1016/j.jamda.2012.10.011 [doi]
PST - ppublish
SO  - J Am Med Dir Assoc. 2013 Feb;14(2):114-8. doi: 10.1016/j.jamda.2012.10.011. Epub 
      2012 Dec 28.


PMID- 23273761
OWN - NLM
STAT- MEDLINE
DCOM- 20130328
LR  - 20130114
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 78
DP  - 2013 Feb
TI  - The ongoing westernization of East Asian biomedical ethics in Taiwan.
PG  - 125-9
LID - 10.1016/j.socscimed.2012.12.001 [doi]
LID - S0277-9536(12)00804-0 [pii]
AB  - Family autonomy/family-determination (FA/FD) is deeply rooted in Confucianism,
      and is an important core value in East Asian biomedical ethics. Individual
      autonomy/self-determination (IA/SD) did not originate in East Asia, and is the
      most important core value of Western biomedical ethics. IA/SD and FA/FD are
      different from each other not only because of where they originated but also in
      their general sense and moral foundations. We investigated the influence of
      Western biomedical ethics on the Eastern hemisphere. We examined the secular
      trends of IA/SD use in ethics and biomedical ethics articles published in Taiwan 
      from 1991 to 2010. The published articles were collected from a popular online
      library called the Chinese Electronic Periodical Services. A total of 1737
      articles were associated with ethics, and 300 of them were associated with
      biomedical ethics. The total number of times IA/SD was used in each ethics and
      biomedical ethics article was calculated. The secular trends were plotted
      graphically and analyzed by time series linear regression analysis. The results
      showed that the secular trend of the proportion of the yearly total of biomedical
      ethics articles to the yearly total of ethics articles was significantly
      increasing (p = 0.007). The secular trends of the average of times IA/SD showed
      that one unit of yearly increase was associated with an increment of 0.056 IA/SD 
      use per ethics article (p < 0.001), and 0.331 IA/SD use per biomedical ethics
      article (p = 0.027), respectively. These findings suggest that Western biomedical
      ethics have become increasingly influential in Taiwan over the past two decades. 
      Thus, assuming that FA/FD takes priority over IA/SD in an East Asian medical
      encounter is too simplistic. Whether FA/FD or IA/SD takes priority in a medical
      encounter should be carefully evaluated.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Chen, Yen-Yuan
AU  - Chen YY
AD  - Department of Medical Education, National Taiwan University Hospital, Taipei,
      Taiwan, ROC.
FAU - Tsai, Shih-Li
AU  - Tsai SL
FAU - Yang, Chih-Wei
AU  - Yang CW
FAU - Ni, Yen-Hsuan
AU  - Ni YH
FAU - Chang, Shan-Chwen
AU  - Chang SC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121212
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - *Acculturation
MH  - Bioethics/*trends
MH  - Confucianism
MH  - Family
MH  - Humans
MH  - Personal Autonomy
MH  - Publishing/statistics & numerical data
MH  - *Social Identification
MH  - Taiwan
EDAT- 2013/01/01 06:00
MHDA- 2013/03/30 06:00
CRDT- 2013/01/01 06:00
PHST- 2012/01/31 00:00 [received]
PHST- 2012/11/05 00:00 [revised]
PHST- 2012/12/03 00:00 [accepted]
PHST- 2013/01/01 06:00 [entrez]
PHST- 2013/01/01 06:00 [pubmed]
PHST- 2013/03/30 06:00 [medline]
AID - S0277-9536(12)00804-0 [pii]
AID - 10.1016/j.socscimed.2012.12.001 [doi]
PST - ppublish
SO  - Soc Sci Med. 2013 Feb;78:125-9. doi: 10.1016/j.socscimed.2012.12.001. Epub 2012
      Dec 12.


PMID- 23273731
OWN - NLM
STAT- MEDLINE
DCOM- 20130930
LR  - 20130409
IS  - 1873-6882 (Electronic)
IS  - 0959-4388 (Linking)
VI  - 23
IP  - 2
DP  - 2013 Apr
TI  - Consciousness supporting networks.
PG  - 239-44
LID - 10.1016/j.conb.2012.12.003 [doi]
LID - S0959-4388(12)00192-4 [pii]
AB  - Functional neuroimaging shows that patients with disorders of consciousness
      exhibit disrupted system-level functional connectivity. Unresponsive/"vegetative 
      state" patients preserve wakefulness networks of brainstem and basal forebrain
      but the cerebral networks accounting for external perceptual awareness and
      internal self-related mentation are disrupted. Specifically, the 'external
      awareness' network encompassing lateral fronto-temporo-parietal cortices
      bilaterally, and the 'internal awareness' network including midline anterior
      cingulate/mesiofrontal and posterior cingulate/precuneal cortices, are
      functionally disconnected. By contrast, patients in minimally conscious state
      'minus', who show non-reflex behaviors, are characterized by right-lateralized
      recovery of the external awareness network. Similarly, patients who evolve to
      minimally conscious state 'plus' and respond to commands recover the dominant
      left-lateralized language network. Now, the use of active experimental paradigms 
      targeting at detecting motor-independent signs of awareness or even establishing 
      communication with these patients, challenge these two clinical boundaries. Such 
      advances are naturally accompanied by legitimate neuroscientific and ethical
      queries demanding our attention on the medical implementations of this new
      knowledge.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Demertzi, Athena
AU  - Demertzi A
AD  - Coma Science Group, Cyclotron Research Center & CHU Neurology Department, Allee
      du 6 aout n degrees 8, Sart Tilman B30, University of Liege, 4000 Liege, Belgium.
      a.demertzi@ulg.ac.be
FAU - Soddu, Andrea
AU  - Soddu A
FAU - Laureys, Steven
AU  - Laureys S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20121227
PL  - England
TA  - Curr Opin Neurobiol
JT  - Current opinion in neurobiology
JID - 9111376
SB  - IM
MH  - Animals
MH  - *Awareness
MH  - Brain/*physiology
MH  - Consciousness/*physiology
MH  - Humans
MH  - Neural Pathways/*physiology
EDAT- 2013/01/01 06:00
MHDA- 2013/10/01 06:00
CRDT- 2013/01/01 06:00
PHST- 2012/10/31 00:00 [received]
PHST- 2012/11/26 00:00 [revised]
PHST- 2012/12/04 00:00 [accepted]
PHST- 2013/01/01 06:00 [entrez]
PHST- 2013/01/01 06:00 [pubmed]
PHST- 2013/10/01 06:00 [medline]
AID - S0959-4388(12)00192-4 [pii]
AID - 10.1016/j.conb.2012.12.003 [doi]
PST - ppublish
SO  - Curr Opin Neurobiol. 2013 Apr;23(2):239-44. doi: 10.1016/j.conb.2012.12.003. Epub
      2012 Dec 27.


PMID- 23273555
OWN - NLM
STAT- MEDLINE
DCOM- 20130603
LR  - 20121231
IS  - 1879-193X (Electronic)
IS  - 0890-4065 (Linking)
VI  - 27
IP  - 1
DP  - 2013 Jan
TI  - Designing 'older' rather than denying ageing: problematizing anti-ageing
      discourse in relation to cosmetic surgery undertaken by older people.
PG  - 38-46
LID - 10.1016/j.jaging.2012.11.001 [doi]
LID - S0890-4065(12)00077-1 [pii]
AB  - This paper problematizes anti-ageing discourse and interpretations that cosmetic 
      surgery is an ageist practice and older people who undergo cosmetic surgery are
      denying ageing. It argues that conceptions of cosmetic surgery as anti-ageing are
      premised on an essentialist conception of the 'naturally ageing body'. Interview 
      data and media texts are used to demonstrate how, through the notion of "re"
      suggested by terms such as rejuvenation, reversal and renewal, anti-ageing
      discourses inscribe 'ageing' in the practice of cosmetic surgery by older people.
      The oppressive interpretation that older people who undergo cosmetic surgery are 
      'denying ageing,' and associated subjection to moral critique, are effects of
      this discourse. To counter interpretations of cosmetic surgery as 'anti-ageing', 
      the paper takes up the idea that cosmetic surgery is undertaken to look better
      not younger. To advance this argument, the paper suggests that the forms of
      rationality associated with cosmetic surgery constitute a contemporary regimen of
      'care of the self' which enable ethical agency and creative self-stylisation.
      Through this framework cosmetic surgery can be re-imagined as a practice for
      designing 'older' rather than denying ageing.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Garnham, Bridget
AU  - Garnham B
AD  - School of Psychology, Social Work and Social Policy, University of South
      Australia, Adelaide, Australia. Bridget.Garnham@unisa.edu.au
LA  - eng
PT  - Journal Article
DEP - 20121121
PL  - England
TA  - J Aging Stud
JT  - Journal of aging studies
JID - 8916517
SB  - IM
MH  - Adaptation, Psychological
MH  - Aged
MH  - Aging/*psychology
MH  - Body Image
MH  - Empirical Research
MH  - Female
MH  - Humans
MH  - Male
MH  - Mass Media
MH  - *Self Concept
MH  - Surgery, Plastic/*psychology
EDAT- 2013/01/01 06:00
MHDA- 2013/06/05 06:00
CRDT- 2013/01/01 06:00
PHST- 2012/08/07 00:00 [received]
PHST- 2012/10/21 00:00 [revised]
PHST- 2012/11/01 00:00 [accepted]
PHST- 2013/01/01 06:00 [entrez]
PHST- 2013/01/01 06:00 [pubmed]
PHST- 2013/06/05 06:00 [medline]
AID - S0890-4065(12)00077-1 [pii]
AID - 10.1016/j.jaging.2012.11.001 [doi]
PST - ppublish
SO  - J Aging Stud. 2013 Jan;27(1):38-46. doi: 10.1016/j.jaging.2012.11.001. Epub 2012 
      Nov 21.


PMID- 23273495
OWN - NLM
STAT- MEDLINE
DCOM- 20140428
LR  - 20130909
IS  - 2210-741X (Electronic)
IS  - 2210-7401 (Linking)
VI  - 37
IP  - 4
DP  - 2013 Sep
TI  - The effect of HLA-DQB1 alleles on virologic breakthroughs during chronic
      hepatitis B treatment with genetically low barrier drugs.
PG  - 359-64
LID - 10.1016/j.clinre.2012.10.013 [doi]
LID - S2210-7401(12)00332-4 [pii]
AB  - BACKGROUND: Chronic hepatitis B treatment with oral antiviral drugs is a long
      course. During this course, antiviral resistance is a serious issue,
      particularly, if genetically low barrier drugs are in use. Host immunity is
      accepted to have an effect on antiviral resistance development. The earliest
      clinical sign of drug resistance is virologic breakthrough. In this study, we
      aimed to investigate the relation between HLA-DQB1 alleles and virologic
      breakthrough events. SUBJECTS AND METHODS: The patient records at single
      institution hepatology clinic were reviewed. Local institution ethics committee
      approval was taken. The patients' demographic data, virologic parameters,
      treatment statues were noted. Patients who had received lamivudine or adefovir
      were recruited and grouped into two according to virologic breakthrough
      occurrence. Patients who were not compliant to the given treatment were excluded.
      Blood samples were taken for DNA extraction. HLA-DQB1 alleles were determined at 
      high level by sequence-speci fi c primers-polymerase chain reaction. The
      distribution of DQB1 alleles among groups was analyzed. RESULTS: One hundred
      ninety-eight patients were eligible for the study. Ninety-six of them had
      virologic breakthrough where 102 did not have. DQB1 0503 allele was more frequent
      in patients without breakthrough (28.4% vs. 12.4%, P=0.006). In univariate
      analysis, HBeAg seropositivity (P<0.001), absence of cirrhosis (P=0.007), younger
      age (P=0.002) and higher pretreatment logDNA (P<0.001) were related to
      breakthrough events. However, in multivariate analysis only logDNA (P<0.001) and 
      DQB1*0503 (P=0.02) allele revealed statistically significant relation with
      breakthrough events. CONCLUSION: Host immunity may have an effect on outcome
      during treatment with oral antiviral drugs. A patient with better immunologic
      profile may suppress the viral replication better and this may cause less
      resistance occurrence during treatment with genetically low barrier drugs.
CI  - Copyright (c) 2012 Elsevier Masson SAS. All rights reserved.
FAU - Doganay, Levent
AU  - Doganay L
AD  - Department of Gastroenterology, Goztepe Teaching and Research Hospital, Medeniyet
      University, Istanbul, Turkey. levent.doganay@ueh.gov.tr
FAU - Tuncer, Ilyas
AU  - Tuncer I
FAU - Katrinli, Seyma
AU  - Katrinli S
FAU - Enc, Feruze Yilmaz
AU  - Enc FY
FAU - Ozturk, Oguzhan
AU  - Ozturk O
FAU - Colak, Yasar
AU  - Colak Y
FAU - Ulasoglu, Celal
AU  - Ulasoglu C
FAU - Dinler, Gizem
AU  - Dinler G
LA  - eng
PT  - Journal Article
DEP - 20121227
PL  - France
TA  - Clin Res Hepatol Gastroenterol
JT  - Clinics and research in hepatology and gastroenterology
JID - 101553659
RN  - 0 (Antiviral Agents)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (Organophosphonates)
RN  - 0 (RNA, Viral)
RN  - 2T8Q726O95 (Lamivudine)
RN  - 6GQP90I798 (adefovir)
RN  - JAC85A2161 (Adenine)
SB  - IM
MH  - Adenine/*analogs & derivatives/pharmacology/therapeutic use
MH  - Adult
MH  - Alleles
MH  - Antiviral Agents/*pharmacology/*therapeutic use
MH  - Drug Resistance, Viral
MH  - Female
MH  - HLA-DQ beta-Chains/*genetics
MH  - Hepatitis B virus/*drug effects/*genetics
MH  - Hepatitis B, Chronic/blood/*drug therapy/*virology
MH  - Humans
MH  - Lamivudine/*pharmacology/*therapeutic use
MH  - Male
MH  - Organophosphonates/*pharmacology/*therapeutic use
MH  - RNA, Viral/blood
EDAT- 2013/01/01 06:00
MHDA- 2014/04/29 06:00
CRDT- 2013/01/01 06:00
PHST- 2012/07/27 00:00 [received]
PHST- 2012/08/21 00:00 [revised]
PHST- 2012/10/08 00:00 [accepted]
PHST- 2013/01/01 06:00 [entrez]
PHST- 2013/01/01 06:00 [pubmed]
PHST- 2014/04/29 06:00 [medline]
AID - S2210-7401(12)00332-4 [pii]
AID - 10.1016/j.clinre.2012.10.013 [doi]
PST - ppublish
SO  - Clin Res Hepatol Gastroenterol. 2013 Sep;37(4):359-64. doi:
      10.1016/j.clinre.2012.10.013. Epub 2012 Dec 27.


PMID- 23272600
OWN - NLM
STAT- MEDLINE
DCOM- 20130122
LR  - 20121231
IS  - 0391-9714 (Print)
IS  - 0391-9714 (Linking)
VI  - 34
IP  - 1-2
DP  - 2012
TI  - Human evolution across the disciplines: spotlights on American anthropology and
      genetics.
PG  - 211-36
AB  - When thinking about human evolution across the disciplines, terms such as
      "anthropological genetics" or "genetic anthropology" that brazenly defy the
      existence of the two-cultures divide seem to promise important insights. They
      refer to the application of genetic techniques to the past of humankind and human
      groups, a fact emphasized most strongly by the expression "genetic history." Such
      daring linguistic alliances have been forming since 1962 when the name "molecular
      anthropology" was introduced in the American context. This was an opportune
      moment for biochemists and physical chemists to enter anthropology, because in
      the U.S. a rapprochement between the fields was aimed for. However, a belief in
      and a discourse of a hierarchy of disciplines structured along the lines of
      methodology and epistemic object worked as an obstacle to the achievement of
      transdisciplinarity. Especially the DNA-sequence, initially approached through
      the proxy of the protein, was regarded as the most informative historical
      document due to its distance from the environment and its amenability to rigorous
      scientific techniques. These notions had a particular power at a time when
      anthropology was confronted with its legacy of race science. For some, the
      perceived objectivity of the new molecular approaches and the neutrality of
      molecules would render anthropology more natural-scientific and by inference less
      culturally contaminated. Others, to the contrary, believed that this legacy
      demanded a holistic and ethically reflexive anthropology. The different
      perceptions thus went along with different understandings of such crucial terms
      as "anthropology" and "history." In the paper, I revisit interfaces between
      different anthropological fields in the U.S. context and suggest that the beliefs
      in a hierarchy of approaches as well as in a nature free from culture embodied in
      the DNA-sequence has worked as one of the primary obstacles to an integration of 
      these fields.
FAU - Sommer, Marianne
AU  - Sommer M
AD  - Department for Cultural and Science Studies, University of Lucerne, 6002 Luzern, 
      Switzerland.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - Switzerland
TA  - Hist Philos Life Sci
JT  - History and philosophy of the life sciences
JID - 8003052
SB  - IM
MH  - Animals
MH  - Anthropology/*history
MH  - *Biological Evolution
MH  - Genetics/*history
MH  - Genetics, Population/history
MH  - History, 20th Century
MH  - History, 21st Century
MH  - *Hominidae
MH  - Humans
MH  - *Interdisciplinary Studies
MH  - *Interprofessional Relations
MH  - United States
EDAT- 2013/01/01 06:00
MHDA- 2013/01/23 06:00
CRDT- 2013/01/01 06:00
PHST- 2013/01/01 06:00 [entrez]
PHST- 2013/01/01 06:00 [pubmed]
PHST- 2013/01/23 06:00 [medline]
PST - ppublish
SO  - Hist Philos Life Sci. 2012;34(1-2):211-36.


PMID- 23272519
OWN - NLM
STAT- MEDLINE
DCOM- 20130307
LR  - 20121231
IS  - 0048-7848 (Print)
IS  - 0048-7848 (Linking)
VI  - 116
IP  - 3
DP  - 2012 Jul-Sep
TI  - Medical and ethical dilemma in brain death.
PG  - 731-8
AB  - For centuries, death has been defined, medically speaking, as the irreversible
      cessation of breathing and of nervous and cardiac activity. What radically
      changed this definition was the introduction of the concept "brain death" in
      1968, by the "Ad Hoc Committee of the Harvard Medical School". According to it,
      the irreversible coma was associated with brain death and considered to be a
      criterion for the diagnosis of the deceased individual. The evergrowing need for 
      transplant organs (provided this respects the dead honor rule, stipulating that
      organs can't be harvested unless someone is deceased) lead to making arbitrary
      decisions regarding the establishment of the exact time of death during the
      process of "losing life". What actually triggers the controversy related to the
      concept of brain death is the dilemma of associating this concept with that of
      biologic death or death of the person, the difference between the two being made 
      by whether the mental characteristics are accepted or not in defining and
      individualizing the death of the human being. Given these circumstances, a
      dilemma appears--that of defining the death of the individual: we define death,
      as it has been for centuries, as the moment when the cardio-respiratory function 
      no longer exists, which leads to the loss of tens of thousands of lives that
      might have been saved through transplant. Yet, this may lead to manipulating the 
      border between life and death, with the risk of trespassing each individual's
      right to life.
FAU - Streba, Irina
AU  - Streba I
AD  - School of Medicine, University of Medicine and Pharmacy Grigore T. Popa-Iasi.
FAU - Damian, Simona
AU  - Damian S
FAU - Ioan, Beatrice
AU  - Ioan B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Romania
TA  - Rev Med Chir Soc Med Nat Iasi
JT  - Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi
JID - 0413735
SB  - IM
MH  - Brain Death/*diagnosis
MH  - Decision Making/*ethics
MH  - Humans
MH  - Romania
MH  - Tissue and Organ Harvesting/*ethics/legislation & jurisprudence
MH  - *Value of Life
EDAT- 2013/01/01 06:00
MHDA- 2013/03/08 06:00
CRDT- 2013/01/01 06:00
PHST- 2013/01/01 06:00 [entrez]
PHST- 2013/01/01 06:00 [pubmed]
PHST- 2013/03/08 06:00 [medline]
PST - ppublish
SO  - Rev Med Chir Soc Med Nat Iasi. 2012 Jul-Sep;116(3):731-8.


PMID- 23272507
OWN - NLM
STAT- MEDLINE
DCOM- 20130307
LR  - 20141120
IS  - 0048-7848 (Print)
IS  - 0048-7848 (Linking)
VI  - 116
IP  - 3
DP  - 2012 Jul-Sep
TI  - Ethics of prevention through vaccination.
PG  - 665-8
FAU - Azoicai, Doina
AU  - Azoicai D
LA  - eng
PT  - Editorial
PL  - Romania
TA  - Rev Med Chir Soc Med Nat Iasi
JT  - Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi
JID - 0413735
RN  - 0 (Vaccines)
SB  - IM
MH  - *Communicable Disease Control/methods
MH  - Global Health
MH  - Humans
MH  - Mass Vaccination/*ethics
MH  - Practice Guidelines as Topic
MH  - Preventive Medicine/*ethics/methods
MH  - Primary Prevention/*ethics
MH  - Romania
MH  - Vaccines/*administration & dosage
EDAT- 2013/01/01 06:00
MHDA- 2013/03/08 06:00
CRDT- 2013/01/01 06:00
PHST- 2013/01/01 06:00 [entrez]
PHST- 2013/01/01 06:00 [pubmed]
PHST- 2013/03/08 06:00 [medline]
PST - ppublish
SO  - Rev Med Chir Soc Med Nat Iasi. 2012 Jul-Sep;116(3):665-8.


PMID- 23272491
OWN - NLM
STAT- MEDLINE
DCOM- 20130516
LR  - 20211203
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 26
IP  - 20
DP  - 2012 Oct
TI  - [Relationship between rs1057141 and rs1135216 polymorphisms of TAP1 gene and
      allergic rhinitis in Xinjiang Han people].
PG  - 917-20, 925
AB  - OBJECTIVE: To investigate the association between transporter associated with
      antigen processing 1 (TAP1) rs1057141 and rs1135216 gene polymorphisms and
      predisposition to allergic rhinitis (AR) in Xinjiang Han people. METHOD: A case
      control study was conducted. The region of the TAP1 * rs1057141 and rs1135216 was
      studied in 150 Xinjiang Han people with allergic rhinitis and 150 normal controls
      by using SNaPshot system, and these data were compared with other ethics groups
      in the world according to the NCBI gene bank. RESULT: The genotypes distribution 
      of the group were in the Hardy-Weinberg equilibrium(P>0.05). The frequencies of
      three genotypes(G/G, G/A, A/A) of TAP1 * rs1057141 were 4.00%, 30.00%, 66.00% in 
      controls and 2.70%, 33.30%, 64.00% in AR groups , which showed no difference
      (P>0.05). The frequencies of three genotypes (G/G,G/A,A/A) of TAP1 * rs1135216
      were 2.0%, 28.7%, 69.3% in controls and 1.30%, 27.30%, 71.40% in AR groups, which
      showed no difference either (P>0.05). According to the NCBI database, there was
      difference between Xinjiang Han people and other ethnics in the world.
      CONCLUSION: Lacking association was found between the mutation of TAP1 *
      rs1057141, rs1135216 gene G allele and allergic rhinitis in the Xinjiang Han
      people. Maybe TAP1 * rs1057141, rs1135216 were not susceptibility genes to AR.
      And apparent differences existed in TAP1 gene polymorphisms between Xinjiang Han 
      people and other ethnic groups in the world.
FAU - Chen, Qingyong
AU  - Chen Q
AD  - Department of Otorhinolaryngology, First Affiliated Hospital of Xinjiang Medical 
      University, Urumqi, 830054, China.
FAU - Liu, Zhilian
AU  - Liu Z
FAU - Zhang, Hua
AU  - Zhang H
LA  - chi
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - China
TA  - Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B, Member 2)
RN  - 0 (ATP-Binding Cassette Transporters)
RN  - 0 (TAP1 protein, human)
SB  - IM
MH  - ATP Binding Cassette Transporter, Subfamily B, Member 2
MH  - ATP-Binding Cassette Transporters/*genetics
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Asians/genetics
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - China/epidemiology
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - *Polymorphism, Single Nucleotide
MH  - Rhinitis, Allergic
MH  - Rhinitis, Allergic, Perennial/epidemiology/*genetics
EDAT- 2013/01/01 06:00
MHDA- 2013/05/17 06:00
CRDT- 2013/01/01 06:00
PHST- 2013/01/01 06:00 [entrez]
PHST- 2013/01/01 06:00 [pubmed]
PHST- 2013/05/17 06:00 [medline]
PST - ppublish
SO  - Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 Oct;26(20):917-20, 925.


PMID- 23272475
OWN - NLM
STAT- MEDLINE
DCOM- 20130226
LR  - 20121231
IS  - 0035-2640 (Print)
IS  - 0035-2640 (Linking)
VI  - 62
IP  - 9
DP  - 2012 Nov
TI  - [Withdrawing and withholding treatments in acute severe stroke patients in the
      elderly].
PG  - 1243-5
AB  - Stroke can produce irreversible brain damage of massive proportion leading to
      severe disability and poor quality of life. When prognosis is very poor,
      "do-not-resuscitate (DNR) orders" and "withhold- or withdrawal-of-treatment
      (WHDT)" may be discussed. Precise estimates of withhold and withdrawal of
      treatment are not available, but studies have shown that DNR orders are
      relatively frequent in acute stroke (up to 30% of all patients). DNR orders are
      closely associated with age, comorbidities, and severity of neurological deficit.
      The main explicit criteria for WHDT is the risk of "unacceptable" disability,
      which raises many ethical questions. Evaluation of neurological outcome is highly
      uncertain and difficult and does not always reflect quality of life. Decisions
      for life sustaining therapies in severe stroke are always difficult and often
      based on subjective and uncertain criteria. We have to improve prognosis
      estimation and our understanding of patient's preferences to promote patient
      centered care. Ethical approach may guide these complex decisions.
FAU - Crozier, Sophie
AU  - Crozier S
AD  - Service des urgences cerebro-vasculaires, groupe hospitalier de La
      Pitie-Salpetriere, 75013 Paris, France. sophie.crozier@psl.aphp.fr
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Limitations et arrets de traitement a la phase aigue des AVC graves chez le sujet
      age.
PL  - France
TA  - Rev Prat
JT  - La Revue du praticien
JID - 0404334
SB  - IM
MH  - Aged
MH  - Humans
MH  - Severity of Illness Index
MH  - Stroke/*therapy
MH  - *Withholding Treatment
EDAT- 2013/01/01 06:00
MHDA- 2013/02/27 06:00
CRDT- 2013/01/01 06:00
PHST- 2013/01/01 06:00 [entrez]
PHST- 2013/01/01 06:00 [pubmed]
PHST- 2013/02/27 06:00 [medline]
PST - ppublish
SO  - Rev Prat. 2012 Nov;62(9):1243-5.


PMID- 28216801
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 0162-2439 (Print)
IS  - 0162-2439 (Linking)
VI  - 38
IP  - 2
DP  - 2013
TI  - Genomic Justice for Native Americans: Impact of the Havasupai Case on Genetic
      Research.
PG  - 201-223
LID - 10.1177/0162243912470009 [doi]
AB  - In 2004, the Havasupai Tribe filed a lawsuit against the Arizona Board of Regents
      and Arizona State University (ASU) researchers upon discovering their DNA
      samples, initially collected for genetic studies on type 2 diabetes, had been
      used in several other genetic studies. The lawsuit reached a settlement in April 
      2010 that included monetary compensation and return of DNA samples to the
      Havasupai but left no legal precedent for researchers. Through semistructured
      interviews, institutional review board (IRB) chairs and human genetics
      researchers at US research institutions revealed their perspectives on the
      Havasupai lawsuit. For interviewees, the suit drew attention to indigenous
      concerns over genetic studies and increased their awareness of indigenous views. 
      However, interviewees perceived no direct impact from the Havasupai case on their
      work; if they did, it was the perceived need to safeguard themselves by obtaining
      broad consent or shying away from research with indigenous communities
      altogether, raising important questions of justice for indigenous and minority
      participants. If researchers and IRBs do not change their practices in light of
      this case, these populations will likely continue to be excluded from a majority 
      of research studies and left with less access to resources and potential benefit 
      from genetic research participation.
FAU - Garrison, Nanibaa' A
AU  - Garrison NA
AD  - Center for Integration of Research on Genetics & Ethics, Stanford Center for
      Biomedical Ethics, Stanford, CA, USA.
LA  - eng
GR  - F32 HG005931/HG/NHGRI NIH HHS/United States
GR  - P50 HG003389/HG/NHGRI NIH HHS/United States
PT  - Journal Article
DEP - 20121221
PL  - United States
TA  - Sci Technol Human Values
JT  - Science, technology & human values
JID - 9440757
PMC - PMC5310710
MID - NIHMS843786
OTO - NOTNLM
OT  - ethics
OT  - inequality
OT  - justice
OT  - other
OT  - protest
COIS- Declaration of Conflicting Interests The author(s) declared no potential
      conflicts of interest with respect to the research, authorship, and/or
      publication of this article.
EDAT- 2013/01/01 00:00
MHDA- 2013/01/01 00:01
CRDT- 2017/02/21 06:00
PHST- 2017/02/21 06:00 [entrez]
PHST- 2013/01/01 00:00 [pubmed]
PHST- 2013/01/01 00:01 [medline]
AID - 10.1177/0162243912470009 [doi]
PST - ppublish
SO  - Sci Technol Human Values. 2013;38(2):201-223. doi: 10.1177/0162243912470009. Epub
      2012 Dec 21.


PMID- 26317093
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150828
LR  - 20201001
IS  - 2314-4262 (Print)
IS  - 2314-4262 (Linking)
VI  - 2013
DP  - 2013
TI  - Incidental Findings in Neuroimaging: Ethical and Medicolegal Considerations.
PG  - 439145
LID - 10.1155/2013/439145 [doi]
AB  - With the rapid advances in neurosciences in the last three decades, there has
      been an exponential increase in the use of neuroimaging both in basic sciences
      and clinical research involving human subjects. During routine neuroimaging,
      incidental findings that are not part of the protocol or scope of research agenda
      can occur and they often pose a challenge as to how they should be handled to
      abide by the medicolegal principles of research ethics. This paper reviews the
      issue from various ethical (do no harm, general duty to rescue, and mutual
      benefits and owing) and medicolegal perspectives (legal liability, fiduciary
      duties, Law of Tort, and Law of Contract) with a suggested protocol of approach.
FAU - Leung, Lawrence
AU  - Leung L
AD  - Centre of Neurosciences Study, Queen's University, 18 Stuart Street, Kingston,
      ON, Canada K7L 3N6 ; Centre of Studies in Primary Care, Queen's University, 220
      Bagot Street, Kingston, ON, Canada K7L 5E9 ; Department of Family Medicine,
      Queen's University, 220 Bagot Street, Kingston, ON, Canada K7L 5E9.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121120
PL  - United States
TA  - Neurosci J
JT  - Neuroscience journal
JID - 101622106
PMC - PMC4475583
EDAT- 2013/01/01 00:00
MHDA- 2013/01/01 00:01
CRDT- 2015/08/29 06:00
PHST- 2012/08/24 00:00 [received]
PHST- 2012/10/15 00:00 [revised]
PHST- 2012/10/25 00:00 [accepted]
PHST- 2015/08/29 06:00 [entrez]
PHST- 2013/01/01 00:00 [pubmed]
PHST- 2013/01/01 00:01 [medline]
AID - 10.1155/2013/439145 [doi]
PST - ppublish
SO  - Neurosci J. 2013;2013:439145. doi: 10.1155/2013/439145. Epub 2012 Nov 20.


PMID- 25973187
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150514
LR  - 20200930
IS  - 2049-0801 (Print)
IS  - 2049-0801 (Linking)
VI  - 2
IP  - 1
DP  - 2013
TI  - Maternal Choice in the UK Should Be Promoted Despite the Current Era of Financial
      Austerity.
PG  - 32-5
LID - 10.1016/S2049-0801(13)70026-8 [doi]
FAU - Oxley, Samuel G
AU  - Oxley SG
AD  - University College London, London, UK.
FAU - Edison, Eric
AU  - Edison E
AD  - University College London, London, UK.
LA  - eng
PT  - Journal Article
DEP - 20121120
PL  - England
TA  - Ann Med Surg (Lond)
JT  - Annals of medicine and surgery (2012)
JID - 101616869
PMC - PMC4326117
OTO - NOTNLM
OT  - Caesarian Section
OT  - Delivery
OT  - Ethics
OT  - Maternal Choice
EDAT- 2013/01/01 00:00
MHDA- 2013/01/01 00:01
CRDT- 2015/05/15 06:00
PHST- 2012/10/02 00:00 [received]
PHST- 2012/11/05 00:00 [accepted]
PHST- 2015/05/15 06:00 [entrez]
PHST- 2013/01/01 00:00 [pubmed]
PHST- 2013/01/01 00:01 [medline]
AID - 10.1016/S2049-0801(13)70026-8 [doi]
AID - S2049-0801(13)70026-8 [pii]
PST - epublish
SO  - Ann Med Surg (Lond). 2012 Nov 20;2(1):32-5. doi: 10.1016/S2049-0801(13)70026-8.
      eCollection 2013.


PMID- 25073839
OWN - NLM
STAT- MEDLINE
DCOM- 20150401
LR  - 20140730
IS  - 1752-0606 (Electronic)
IS  - 0194-472X (Linking)
VI  - 39
IP  - 1
DP  - 2013 Jan
TI  - Dyadic research in marriage and family therapy: methodological considerations.
PG  - 5-16
LID - 10.1111/j.1752-0606.2012.00306.x [doi]
AB  - With training that emphasizes relationship systems, marriage and family
      therapists are uniquely attuned to interpersonal dynamics, interdependence, and
      the influence of relationships on individuals' perceptions, beliefs, and
      attitudes. While recent statistical advances have contributed to a proliferation 
      of resources designed to introduce researchers to dyadic data analysis,
      guidelines related to the methodological aspects of dyadic research design have
      received less attention. Given the potential advantages of dyadic designs for
      examining couple and family relational and therapeutic processes, the purpose of 
      this article is to introduce marriage and family therapy researchers to dyadic
      research methodology. Using examples from our own research, we discuss
      methodological considerations and lessons learned related to sampling,
      measurement, data collection, and ethics. Recommendations for future dyadic
      research are provided.
CI  - (c) 2012 American Association for Marriage and Family Therapy.
FAU - Wittenborn, Andrea K
AU  - Wittenborn AK
AD  - Virginia TechAuburn University.
FAU - Dolbin-MacNab, Megan L
AU  - Dolbin-MacNab ML
FAU - Keiley, Margaret K
AU  - Keiley MK
LA  - eng
PT  - Journal Article
DEP - 20120509
PL  - United States
TA  - J Marital Fam Ther
JT  - Journal of marital and family therapy
JID - 7904614
SB  - IM
MH  - Behavioral Research/*methods/standards
MH  - Family Therapy/*methods/standards
MH  - Humans
MH  - Marital Therapy/*methods/standards
MH  - Research Design/*standards
EDAT- 2013/01/01 00:00
MHDA- 2015/04/02 06:00
CRDT- 2014/07/31 06:00
PHST- 2014/07/31 06:00 [entrez]
PHST- 2013/01/01 00:00 [pubmed]
PHST- 2015/04/02 06:00 [medline]
AID - 10.1111/j.1752-0606.2012.00306.x [doi]
PST - ppublish
SO  - J Marital Fam Ther. 2013 Jan;39(1):5-16. doi: 10.1111/j.1752-0606.2012.00306.x.
      Epub 2012 May 9.


PMID- 24783025
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140430
LR  - 20220330
IS  - 2235-0640 (Print)
IS  - 2235-0640 (Linking)
VI  - 1
IP  - 4
DP  - 2013 Jan
TI  - 2012 European thyroid association guidelines for genetic testing and its clinical
      consequences in medullary thyroid cancer.
PG  - 216-31
LID - 10.1159/000346174 [doi]
AB  - Twenty-five percent of medullary thyroid cancers (MTC) are familial and inherited
      as an autosomal dominant trait. Three different phenotypes can be distinguished: 
      multiple endocrine neoplasia (MEN) types 2A and 2B, in which the MTC is
      associated with other endocrine neoplasias, and familial MTC (FMTC), which occurs
      in isolation. The discovery that germline RET oncogene activating mutations are
      associated with 95-98% of MEN 2/FMTC syndromes and the availability of genotyping
      to identify mutations in affected patients and their relatives has revolutionized
      the diagnostic and therapeutic strategies available for the management of these
      patients. All patients with MTC, both those with a positive familial history and 
      those apparently sporadic, should be submitted to RET genetic screening. Once an 
      RET mutation has been confirmed in an index patient, first-degree relatives
      should be screened rapidly to identify the 50% who inherited the mutation and are
      therefore at risk for development of MTC. Relatives in whom no RET mutation is
      identified can be reassured and discharged from further follow-up, whereas
      RET-positive subjects (i.e. gene carriers) must be investigated and a therapeutic
      strategy initiated. These guideline recommendations are derived from the most
      recent studies identifying phenotype-genotype correlations following the
      discovery of causative RET gene mutations in MEN 2 eighteen years ago. Three
      major points will be discussed: (a) identification of patients and relatives who 
      should have genetic screening for RET mutations, (b) management of asymptomatic
      gene carriers, and (c) ethics.
FAU - Elisei, R
AU  - Elisei R
AD  - Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy.
FAU - Alevizaki, M
AU  - Alevizaki M
AD  - Endocrine Unit, Department of Medical Therapeutics, Athens University School of
      Medicine, Athens, Greece.
FAU - Conte-Devolx, B
AU  - Conte-Devolx B
AD  - Department of Endocrinology, La Timone Hospital, Aix Marseille University,
      Marseille, France.
FAU - Frank-Raue, K
AU  - Frank-Raue K
AD  - Endocrine Practice, Molecular Laboratory, Heidelberg, Germany.
FAU - Leite, V
AU  - Leite V
AD  - Department of Endocrinology, Portuguese Institute of Oncology and CEDOC, Faculty 
      of Medical Sciences, Lisbon, Portugal.
FAU - Williams, G R
AU  - Williams GR
AD  - Molecular Endocrinology Group, Department of Medicine, Hammersmith Hospital,
      Imperial College London, London, UK.
LA  - eng
PT  - Journal Article
DEP - 20121219
PL  - England
TA  - Eur Thyroid J
JT  - European thyroid journal
JID - 101604579
PMC - PMC3821492
OTO - NOTNLM
OT  - Calcitonin
OT  - Gene carriers
OT  - Medullary thyroid cancer
OT  - Multiple endocrine neoplasia
OT  - RET oncogene
EDAT- 2013/01/01 00:00
MHDA- 2013/01/01 00:01
CRDT- 2014/05/01 06:00
PHST- 2012/10/29 00:00 [received]
PHST- 2012/11/30 00:00 [revised]
PHST- 2014/05/01 06:00 [entrez]
PHST- 2013/01/01 00:00 [pubmed]
PHST- 2013/01/01 00:01 [medline]
AID - 10.1159/000346174 [doi]
AID - etj-0001-0216 [pii]
PST - ppublish
SO  - Eur Thyroid J. 2013 Jan;1(4):216-31. doi: 10.1159/000346174. Epub 2012 Dec 19.


PMID- 24527269
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220331
IS  - 2161-1025 (Print)
VI  - Suppl 2
DP  - 2012 Dec 31
TI  - Molecular Targeted Therapies Using Botanicals for Prostate Cancer
      Chemoprevention.
PG  - 005
AB  - In spite of the large number of botanicals demonstrating promise as potential
      cancer chemopreventive agents, most have failed to prove effectiveness in
      clinical trials. Critical requirements for moving botanical agents to
      recommendation for clinical use include adopting a systematic, molecular-target
      based approach and utilizing the same ethical and rigorous methods that are used 
      to evaluate other pharmacological agents. Preliminary data on a mechanistic
      rationale for chemoprevention activity as observed from epidemiological, in vitro
      and preclinical studies, phase I data of safety in suitable cohorts, duration of 
      intervention based on time to progression of pre-neoplastic disease to cancer and
      using a valid panel of biomarkers representing the hypothesized carcinogenesis
      pathway for measuring efficacy must inform the design of clinical trials.
      Botanicals have been shown to influence multiple biochemical and molecular
      cascades that inhibit mutagenesis, proliferation, induce apoptosis, suppress the 
      formation and growth of human cancers, thus modulating several hallmarks of
      carcinogenesis. These agents appear promising in their potential to make a
      dramatic impact in cancer prevention and treatment, with a significantly superior
      safety profile than most agents evaluated to date. The goal of this paper is to
      provide models of translational research based on the current evidence of
      promising botanicals with a specific focus on targeted therapies for PCa
      chemoprevention.
FAU - Kumar, Nagi
AU  - Kumar N
AD  - Department of Epidemiology, H. Lee Moffitt Cancer Center & Research Institute,
      Florida, USA ; University of South Florida College of Medicine, Florida, USA.
FAU - Chornokur, Ganna
AU  - Chornokur G
AD  - Department of Epidemiology, H. Lee Moffitt Cancer Center & Research Institute,
      Florida, USA.
LA  - eng
GR  - P20 MD003375/MD/NIMHD NIH HHS/United States
GR  - R01 CA122060/CA/NCI NIH HHS/United States
GR  - R01 DC012060/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Transl Med (Sunnyvale)
JT  - Translational medicine (Sunnyvale, Calif.)
JID - 101603749
PMC - PMC3920581
MID - NIHMS522088
OTO - NOTNLM
OT  - Chemoprevention
OT  - Curcumin
OT  - Decursin
OT  - Green Tea Polyphenols (GTP)
OT  - Isoflavones
OT  - Prostate cancer
EDAT- 2012/12/31 00:00
MHDA- 2012/12/31 00:01
CRDT- 2014/02/15 06:00
PHST- 2014/02/15 06:00 [entrez]
PHST- 2012/12/31 00:00 [pubmed]
PHST- 2012/12/31 00:01 [medline]
AID - 10.4172/2161-1025.S2-005 [doi]
PST - ppublish
SO  - Transl Med (Sunnyvale). 2012 Dec 31;Suppl 2:005. doi: 10.4172/2161-1025.S2-005.


PMID- 23271849
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121231
LR  - 20211021
IS  - 0300-1652 (Print)
IS  - 0300-1652 (Linking)
VI  - 53
IP  - 2
DP  - 2012 Apr
TI  - The accuracy of 2D ultrasound prenatal sex determination.
PG  - 71-5
LID - 10.4103/0300-1652.103545 [doi]
AB  - BACKGROUND: Pregnant women have been curious about the sex of their unborn child.
      The advent of ultrasound, its application into medicine, and the revolutionary
      changes in its resolution and function has led to the ability to assign a sex to 
      these unborn children, thereby allaying the anxiety of these women but with
      consequent emergent ethical, moral, psycho-social, and medico-legal issues. The
      objectives were to determine the accuracy of sonographic prenatal sex
      determination, perform binary classification test, and the impact it has,
      including mis-diagnosis. MATERIALS AND METHODS: A prospective prenatal
      sonographic sex determination study on 205 consecutive consenting pregnant women 
      aged 20-40 years in a private hospital in Benin between August 2010 and October
      2011. Questionnaires were administered to these women before and after the scan
      and the women were told the sex of the fetuses and their feelings on the
      determined sex recorded. The sex at birth was confirmed and compared to the scan 
      determined gender by their case note and telephone. Relevant discussions during
      the scan and later on were recorded on the questionnaires. The statistical
      package used was SPSS version 17 and binary classification tests were performed. 
      RESULTS: The sensitivity (98.2%) and binary classification components values of
      prenatal sex determination were high with the sensitivity of detecting a female
      higher than that of males. Two males were misdiagnosed as females. Most of the
      women were happy even when the sex differed from that which they desired.
      CONCLUSION: Prenatal sonographic sex determination has a high sensitivity index. 
      Consequently we advocate its use prior to more invasive sex tests.
FAU - Igbinedion, Blessing Ose-Emenim
AU  - Igbinedion BO
AD  - Department of Radiology, University of Benin, Benin.
FAU - Akhigbe, Theophilus Oriazo
AU  - Akhigbe TO
LA  - eng
PT  - Journal Article
PL  - Nigeria
TA  - Niger Med J
JT  - Nigerian medical journal : journal of the Nigeria Medical Association
JID - 0315137
PMC - PMC3530251
OTO - NOTNLM
OT  - Accuracy
OT  - gender determination
OT  - prenatal gender
OT  - prenatal sex
OT  - sex determination
OT  - sonographic sex
OT  - ultrasound sex
EDAT- 2012/12/29 06:00
MHDA- 2012/12/29 06:01
CRDT- 2012/12/29 06:00
PHST- 2012/12/29 06:00 [entrez]
PHST- 2012/12/29 06:00 [pubmed]
PHST- 2012/12/29 06:01 [medline]
AID - 10.4103/0300-1652.103545 [doi]
AID - NMJ-53-71 [pii]
PST - ppublish
SO  - Niger Med J. 2012 Apr;53(2):71-5. doi: 10.4103/0300-1652.103545.


PMID- 23271509
OWN - NLM
STAT- MEDLINE
DCOM- 20130301
LR  - 20211021
IS  - 1940-087X (Electronic)
IS  - 1940-087X (Linking)
IP  - 70
DP  - 2012 Dec 11
TI  - The insect Galleria mellonella as a powerful infection model to investigate
      bacterial pathogenesis.
PG  - e4392
LID - 10.3791/4392 [doi]
LID - 4392 [pii]
AB  - The study of bacterial virulence often requires a suitable animal model.
      Mammalian models of infection are costly and may raise ethical issues. The use of
      insects as infection models provides a valuable alternative. Compared to other
      non-vertebrate model hosts such as nematodes, insects have a relatively advanced 
      system of antimicrobial defenses and are thus more likely to produce information 
      relevant to the mammalian infection process. Like mammals, insects possess a
      complex innate immune system(1). Cells in the hemolymph are capable of
      phagocytosing or encapsulating microbial invaders, and humoral responses include 
      the inducible production of lysozyme and small antibacterial peptides(2,3). In
      addition, analogies are found between the epithelial cells of insect larval
      midguts and intestinal cells of mammalian digestive systems. Finally, several
      basic components essential for the bacterial infection process such as cell
      adhesion, resistance to antimicrobial peptides, tissue degradation and adaptation
      to oxidative stress are likely to be important in both insects and mammals(1).
      Thus, insects are polyvalent tools for the identification and characterization of
      microbial virulence factors involved in mammalian infections. Larvae of the
      greater wax moth Galleria mellonella have been shown to provide a useful insight 
      into the pathogenesis of a wide range of microbial infections including mammalian
      fungal (Fusarium oxysporum, Aspergillus fumigatus, Candida albicans) and
      bacterial pathogens, such as Staphylococcus aureus, Proteus vulgaris, Serratia
      marcescens Pseudomonas aeruginosa, Listeria monocytogenes or Enterococcus
      faecalis(4-7). Regardless of the bacterial species, results obtained with
      Galleria larvae infected by direct injection through the cuticle consistently
      correlate with those of similar mammalian studies: bacterial strains that are
      attenuated in mammalian models demonstrate lower virulence in Galleria, and
      strains causing severe human infections are also highly virulent in the Galleria 
      model(8-11). Oral infection of Galleria is much less used and additional
      compounds, like specific toxins, are needed to reach mortality. G. mellonella
      larvae present several technical advantages: they are relatively large (last
      instar larvae before pupation are about 2 cm long and weight 250 mg), thus
      enabling the injection of defined doses of bacteria; they can be reared at
      various temperatures (20 degrees C to 30 degrees C) and infection studies can be 
      conducted between 15 degrees C to above 37 degrees C(12,13), allowing experiments
      that mimic a mammalian environment. In addition, insect rearing is easy and
      relatively cheap. Infection of the larvae allows monitoring bacterial virulence
      by several means, including calculation of LD50(14), measurement of bacterial
      survival(15,16) and examination of the infection process(17). Here, we describe
      the rearing of the insects, covering all life stages of G. mellonella. We provide
      a detailed protocol of infection by two routes of inoculation: oral and intra
      haemocoelic. The bacterial model used in this protocol is Bacillus cereus, a Gram
      positive pathogen implicated in gastrointestinal as well as in other severe local
      or systemic opportunistic infections(18,19).
FAU - Ramarao, Nalini
AU  - Ramarao N
AD  - INRA, Micalis UMR1319, France. nalini.ramarao@jouy.inra.fr
FAU - Nielsen-Leroux, Christina
AU  - Nielsen-Leroux C
FAU - Lereclus, Didier
AU  - Lereclus D
LA  - eng
PT  - Journal Article
PT  - Video-Audio Media
DEP - 20121211
PL  - United States
TA  - J Vis Exp
JT  - Journal of visualized experiments : JoVE
JID - 101313252
SB  - IM
MH  - Animals
MH  - Bacillus cereus/pathogenicity
MH  - *Disease Models, Animal
MH  - Female
MH  - Gram-Negative Bacteria/*pathogenicity
MH  - Gram-Negative Bacterial Infections/*microbiology
MH  - Gram-Positive Bacteria/*pathogenicity
MH  - Gram-Positive Bacterial Infections/*microbiology
MH  - Larva/microbiology
MH  - Male
MH  - Moths/*microbiology
MH  - Pseudomonas aeruginosa/pathogenicity
MH  - Virulence
PMC - PMC3567165
EDAT- 2012/12/29 06:00
MHDA- 2013/03/02 06:00
CRDT- 2012/12/29 06:00
PHST- 2012/12/29 06:00 [entrez]
PHST- 2012/12/29 06:00 [pubmed]
PHST- 2013/03/02 06:00 [medline]
AID - 4392 [pii]
AID - 10.3791/4392 [doi]
PST - epublish
SO  - J Vis Exp. 2012 Dec 11;(70):e4392. doi: 10.3791/4392.


PMID- 23269903
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121228
LR  - 20211021
IS  - 1226-4512 (Print)
IS  - 1226-4512 (Linking)
VI  - 16
IP  - 6
DP  - 2012 Dec
TI  - Effects of human mesenchymal stem cell transplantation combined with polymer on
      functional recovery following spinal cord hemisection in rats.
PG  - 405-11
LID - 10.4196/kjpp.2012.16.6.405 [doi]
AB  - The spontaneous axon regeneration of damaged neurons is limited after spinal cord
      injury (SCI). Recently, mesenchymal stem cell (MSC) transplantation was proposed 
      as a potential approach for enhancing nerve regeneration that avoids the ethical 
      issues associated with embryonic stem cell transplantation. As SCI is a complex
      pathological entity, the treatment of SCI requires a multipronged approach. The
      purpose of the present study was to investigate the functional recovery and
      therapeutic potential of human MSCs (hMSCs) and polymer in a spinal cord
      hemisection injury model. Rats were subjected to hemisection injuries and then
      divided into three groups. Two groups of rats underwent partial thoracic
      hemisection injury followed by implantation of either polymer only or polymer
      with hMSCs. Another hemisection-only group was used as a control. Behavioral,
      electrophysiological and immunohistochemical studies were performed on all rats. 
      The functional recovery was significantly improved in the polymer with
      hMSC-transplanted group as compared with control at five weeks after
      transplantation. The results of electrophysiologic study demonstrated that the
      latency of somatosensory-evoked potentials (SSEPs) in the polymer with
      hMSC-transplanted group was significantly shorter than in the hemisection-only
      control group. In the results of immunohistochemical study, beta-gal-positive
      cells were observed in the injured and adjacent sites after hMSC transplantation.
      Surviving hMSCs differentiated into various cell types such as neurons,
      astrocytes and oligodendrocytes. These data suggest that hMSC transplantation
      with polymer may play an important role in functional recovery and axonal
      regeneration after SCI, and may be a potential therapeutic strategy for SCI.
FAU - Choi, Ji Soo
AU  - Choi JS
AD  - Department of Physiology, Brain Korea 21 Project for Medical Science, and Brain
      Research Institute, Yonsei University College of Medicine, Seoul 120-752, Korea.
FAU - Leem, Joong Woo
AU  - Leem JW
FAU - Lee, Kyung Hee
AU  - Lee KH
FAU - Kim, Sung-Soo
AU  - Kim SS
FAU - Suh-Kim, Haeyoung
AU  - Suh-Kim H
FAU - Jung, Se Jung
AU  - Jung SJ
FAU - Kim, Un Jeng
AU  - Kim UJ
FAU - Lee, Bae Hwan
AU  - Lee BH
LA  - eng
PT  - Journal Article
DEP - 20121210
PL  - Korea (South)
TA  - Korean J Physiol Pharmacol
JT  - The Korean journal of physiology & pharmacology : official journal of the Korean 
      Physiological Society and the Korean Society of Pharmacology
JID - 9709505
PMC - PMC3526745
OTO - NOTNLM
OT  - Electrophysiology
OT  - Mesenchymal stem cells
OT  - Polymer
OT  - Spinal cord injury
EDAT- 2012/12/28 06:00
MHDA- 2012/12/28 06:01
CRDT- 2012/12/28 06:00
PHST- 2012/08/16 00:00 [received]
PHST- 2012/10/12 00:00 [revised]
PHST- 2012/10/22 00:00 [accepted]
PHST- 2012/12/28 06:00 [entrez]
PHST- 2012/12/28 06:00 [pubmed]
PHST- 2012/12/28 06:01 [medline]
AID - 10.4196/kjpp.2012.16.6.405 [doi]
PST - ppublish
SO  - Korean J Physiol Pharmacol. 2012 Dec;16(6):405-11. doi:
      10.4196/kjpp.2012.16.6.405. Epub 2012 Dec 10.


PMID- 23269022
OWN - NLM
STAT- MEDLINE
DCOM- 20131113
LR  - 20190902
IS  - 0300-9173 (Print)
IS  - 0300-9173 (Linking)
VI  - 49
IP  - 4
DP  - 2012
TI  - [Survey of members of the Japan Geriatric Society regarding the revised version
      of their Position Statement on terminal medicine and care for elderly patients].
PG  - 387-92
AB  - AIM: To clarify the opinions of members of the Japan Geriatric Society regarding 
      the revised version of their Position Statement on terminal medicine and care in 
      elderly patients. METHODS: A self-report questionnaire was sent to special
      honorary members, emeritus academic staff, and officers and delegates of the
      Japan Geriatrics Society (789 people). The questions were: 1) Do you agree with
      the Position Statement as revised by the Ethics Committee of the Japan Geriatric 
      Society or not? 2) Do you have any ideas about any specific item and its' content
      or necessary revisions and if so, what are they? 3) Are there any headings or
      items that should be added to the Q&A section and if so, what are they? RESULTS: 
      The response rate was 28.5% (225/789). Of these, 91.6% agreed with the revised
      version of the Position Statement. More than 80% of respondents had no suggested 
      revisions. Suggested items that should be added to the Q&A were: advanced
      directives or advanced care plans, legal interpretation on the withholding of
      life-support treatments including hemodialysis, the establishment of a guardian
      system, and legal interpretation of the decisions made by the Ethics Committee.
      CONCLUSION: Although most respondents agreed with the revised version of the
      Position Statement, some issues remain to be discussed, including the
      relationship of patient autonomy with the optimal benefits for those in
      terminal-stage disease, the decision-making systems regarding the introduction
      and withholding of life-support treatments such as artificial nutrition,
      artificial ventilation, and hemodialysis.
FAU - Uemura, Kazumasa
AU  - Uemura K
AD  - Center for Medical Education, Nagoya University School of Medicine, Japan.
FAU - Iijima, Setsu
AU  - Iijima S
CN  - Japan Geriatrics Society Ethical Committee
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Nihon Ronen Igakkai Zasshi
JT  - Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics
JID - 7507332
SB  - IM
MH  - Aged
MH  - Geriatrics
MH  - Humans
MH  - Japan
MH  - Role
MH  - Societies, Medical
MH  - *Terminal Care
EDAT- 2012/12/28 06:00
MHDA- 2013/11/14 06:00
CRDT- 2012/12/28 06:00
PHST- 2012/12/28 06:00 [entrez]
PHST- 2012/12/28 06:00 [pubmed]
PHST- 2013/11/14 06:00 [medline]
AID - DN/JST.JSTAGE/geriatrics/49.387 [pii]
AID - 10.3143/geriatrics.49.387 [doi]
PST - ppublish
SO  - Nihon Ronen Igakkai Zasshi. 2012;49(4):387-92. doi: 10.3143/geriatrics.49.387.


PMID- 23268364
OWN - NLM
STAT- MEDLINE
DCOM- 20141112
LR  - 20130920
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 10
DP  - 2013 Oct
TI  - What are the attitudes of strictly-orthodox Jews to clinical trials: are they
      influenced by Jewish teachings?
PG  - 643-6
LID - 10.1136/medethics-2012-100658 [doi]
AB  - In order to explore whether and how Jewish teachings influence the attitudes of
      strictly-orthodox Jews to clinical trials, 10 strictly-orthodox Jews were
      purposively selected and interviewed, using a semi-structured schedule. Relevant 
      literature was searched for similar studies and for publications covering
      relevant Jewish teachings. Thematic analysis was used to analyse transcribed
      interviews and explore relationships between attitudes and Jewish teachings
      identified in the review. Participants' attitudes were influenced in a variety of
      ways: by Jewish teachings on the over-riding importance of preserving life--the
      need to avoid risks affecting life and health, while taking risks to preserve
      life--and the religious obligation to help others, as well as by previous
      experience. Attitudes mirrored those in the general population, enabling many
      participants to reach conclusions that did not differ materially from those of
      the general population or research ethics committees.
FAU - Box Bayes, Joan
AU  - Box Bayes J
LA  - eng
PT  - Journal Article
DEP - 20121225
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Attitude
MH  - Clinical Trials as Topic/*ethics
MH  - *Ethics, Research
MH  - Female
MH  - Health Status
MH  - Humans
MH  - Jews/*psychology
MH  - Judaism/psychology
MH  - Male
MH  - Middle Aged
MH  - Research
MH  - Risk Factors
MH  - Young Adult
OTO - NOTNLM
OT  - Religious Ethics
OT  - Research Ethics
EDAT- 2012/12/27 06:00
MHDA- 2014/11/13 06:00
CRDT- 2012/12/27 06:00
PHST- 2012/12/27 06:00 [entrez]
PHST- 2012/12/27 06:00 [pubmed]
PHST- 2014/11/13 06:00 [medline]
AID - medethics-2012-100658 [pii]
AID - 10.1136/medethics-2012-100658 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Oct;39(10):643-6. doi: 10.1136/medethics-2012-100658. Epub
      2012 Dec 25.


PMID- 23267251
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121226
LR  - 20211021
IS  - 1524-5012 (Print)
IS  - 1524-5012 (Linking)
VI  - 12
IP  - 4
DP  - 2012 Winter
TI  - Bioethics in practice-a quarterly column about medical ethics: do you remember
      the hippocratic oath?
PG  - 298-9
FAU - Pinsky, William W
AU  - Pinsky WW
AD  - Executive Vice President of Clinical Affairs for International Business and Chief
      Academic Officer, Ochsner Health System, and Professor and Head, The University
      of Queensland School of Medicine, Ochsner Clinical School, New Orleans, LA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ochsner J
JT  - The Ochsner journal
JID - 101125795
PMC - PMC3527852
EDAT- 2012/12/26 06:00
MHDA- 2012/12/26 06:01
CRDT- 2012/12/26 06:00
PHST- 2012/12/26 06:00 [entrez]
PHST- 2012/12/26 06:00 [pubmed]
PHST- 2012/12/26 06:01 [medline]
PST - ppublish
SO  - Ochsner J. 2012 Winter;12(4):298-9.


PMID- 23267069
OWN - NLM
STAT- MEDLINE
DCOM- 20130307
LR  - 20220317
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 110
IP  - 2
DP  - 2013 Jan 8
TI  - Adaptation of the genetically tractable malaria pathogen Plasmodium knowlesi to
      continuous culture in human erythrocytes.
PG  - 531-6
LID - 10.1073/pnas.1216457110 [doi]
AB  - Research into the aetiological agent of the most widespread form of severe
      malaria, Plasmodium falciparum, has benefitted enormously from the ability to
      culture and genetically manipulate blood-stage forms of the parasite in vitro.
      However, most malaria outside Africa is caused by a distinct Plasmodium species, 
      Plasmodium vivax, and it has become increasingly apparent that zoonotic infection
      by the closely related simian parasite Plasmodium knowlesi is a frequent cause of
      life-threatening malaria in regions of southeast Asia. Neither of these important
      malarial species can be cultured in human cells in vitro, requiring access to
      primates with the associated ethical and practical constraints. We report the
      successful adaptation of P. knowlesi to continuous culture in human erythrocytes.
      Human-adapted P. knowlesi clones maintain their capacity to replicate in monkey
      erythrocytes and can be genetically modified with unprecedented efficiency,
      providing an important and unique model for studying conserved aspects of
      malarial biology as well as species-specific features of an emerging pathogen.
FAU - Moon, Robert W
AU  - Moon RW
AD  - Division of Parasitology, Medical Research Council National Institute for Medical
      Research, London NW7 1AA, United Kingdom.
FAU - Hall, Joanna
AU  - Hall J
FAU - Rangkuti, Farania
AU  - Rangkuti F
FAU - Ho, Yung Shwen
AU  - Ho YS
FAU - Almond, Neil
AU  - Almond N
FAU - Mitchell, Graham H
AU  - Mitchell GH
FAU - Pain, Arnab
AU  - Pain A
FAU - Holder, Anthony A
AU  - Holder AA
FAU - Blackman, Michael J
AU  - Blackman MJ
LA  - eng
SI  - GENBANK/HF564624
SI  - GENBANK/HF564625
SI  - GENBANK/HF564626
GR  - MC_U117532063/MRC_/Medical Research Council/United Kingdom
GR  - MC_U117532067/MRC_/Medical Research Council/United Kingdom
GR  - U117532063/PHS HHS/United States
GR  - U117532067/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20121224
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (DNA Primers)
SB  - IM
MH  - Adaptation, Biological/genetics/*physiology
MH  - Animals
MH  - Base Sequence
MH  - Cloning, Molecular
MH  - Cryopreservation
MH  - Culture Techniques/*methods
MH  - DNA Primers/genetics
MH  - Erythrocytes/*parasitology
MH  - Genotype
MH  - Humans
MH  - Macaca fascicularis
MH  - Molecular Sequence Data
MH  - Plasmodium knowlesi/*genetics/*growth & development
MH  - Polymerase Chain Reaction
MH  - Sequence Analysis, DNA
MH  - Species Specificity
PMC - PMC3545754
EDAT- 2012/12/26 06:00
MHDA- 2013/03/08 06:00
CRDT- 2012/12/26 06:00
PHST- 2012/12/26 06:00 [entrez]
PHST- 2012/12/26 06:00 [pubmed]
PHST- 2013/03/08 06:00 [medline]
AID - 1216457110 [pii]
AID - 10.1073/pnas.1216457110 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):531-6. doi: 10.1073/pnas.1216457110. 
      Epub 2012 Dec 24.


PMID- 23267048
OWN - NLM
STAT- MEDLINE
DCOM- 20130805
LR  - 20130121
IS  - 1744-5019 (Electronic)
IS  - 0360-5310 (Linking)
VI  - 38
IP  - 1
DP  - 2013 Feb
TI  - The problem with rescue medicine.
PG  - 64-81
LID - 10.1093/jmp/jhs056 [doi]
AB  - Is there a rational and ethical basis for efforts to rescue individuals in dire
      straits? When does rescue have ethical support, and when does it reflect an
      irrational impulse? This paper defines a Rule of Rescue and shows its intuitive
      appeal. It then proceeds to argue that this rule lacks support from standard
      principles of justice and from ethical principles more broadly, and should be
      rejected in many situations. I distinguish between agent-relative and
      agent-neutral reasons, and argue that the Rule of Rescue qualifies only in a
      narrow range of cases where agent-relative considerations apply. I conclude that 
      it would be wise to set aside the Rule of Rescue in many cases, especially those 
      involving public policies, where it has only weak normative justification. The
      broader implications of this analysis are noted.
FAU - Jecker, Nancy S
AU  - Jecker NS
AD  - University of Washington, A 204 Health Sciences Bldg, Seattle, WA 98195 USA.
      nsjecker@uw.edu
LA  - eng
PT  - Journal Article
DEP - 20121223
PL  - United States
TA  - J Med Philos
JT  - The Journal of medicine and philosophy
JID - 7610512
SB  - IM
MH  - Ethical Theory
MH  - *Ethics, Clinical
MH  - Health Care Rationing/*ethics
MH  - Humans
MH  - Intuition
MH  - Relief Work/*ethics
MH  - Rescue Work/*ethics
MH  - Resource Allocation/*ethics
EDAT- 2012/12/26 06:00
MHDA- 2013/08/06 06:00
CRDT- 2012/12/26 06:00
PHST- 2012/12/26 06:00 [entrez]
PHST- 2012/12/26 06:00 [pubmed]
PHST- 2013/08/06 06:00 [medline]
AID - jhs056 [pii]
AID - 10.1093/jmp/jhs056 [doi]
PST - ppublish
SO  - J Med Philos. 2013 Feb;38(1):64-81. doi: 10.1093/jmp/jhs056. Epub 2012 Dec 23.


PMID- 23266203
OWN - NLM
STAT- MEDLINE
DCOM- 20140213
LR  - 20130701
IS  - 1872-9177 (Electronic)
IS  - 1769-7255 (Linking)
VI  - 9
IP  - 4
DP  - 2013 Jul
TI  - [Ethics consultation unit in nephrology (UCEN): review of 10 years of operation
      in the Grenoble area].
PG  - 222-7
LID - 10.1016/j.nephro.2012.10.009 [doi]
LID - S1769-7255(12)00579-2 [pii]
AB  - The existence of an ethics consultation unit in nephrology (UCEN) gives to the
      nephrologist the collegiality required to meet the difficulties of therapeutic
      choice on a legislative level, particularly in indications of stop dialysis. The 
      discussion conducted, outside the emergency, is guided by a tool for reflexion
      that details successive steps necessary to the identification of elements
      required for decision-making. Thanks to complementary skills provided by the
      participants and training acquired, the UCEN can approach other ethic issues
      encountered during practice such as contrindication for a kidney transplantation 
      or maintenance of conservative treatment, or performing invasive procedures on
      patients refusing transfusion. Propositions are not always relevant due to
      opposition or ambivalence of some patients, their relatives, an external or
      disagreements between teams or a mismatch between the technical and the patient's
      condition. These non-conformities decrypted always have an explanation, sometimes
      they are understood and accepted by the teams, and sometimes they became source
      of regrets when they extend life in very poor conditions. The UCEN, if it does
      not solve every single point, remains a place and a time of sharing that face
      difficult situations, help the nephrologist positioning himself on maintaining
      treatments that were first to avoid and prevent the realization of unreasonable
      acts and accept their limits.
CI  - Copyright (c) 2012. Published by Elsevier SAS.
FAU - Maurizi Balzan, Jocelyne
AU  - Maurizi Balzan J
AD  - Pole Digidune, clinique universitaire de nephrologie, hopital Nord, CHU de
      Grenoble, boulevard de la Chantourne, 38700 La Tronche, France.
      JMaurizi@chu-grenoble.fr
FAU - Moreaud, Olivier
AU  - Moreaud O
FAU - Palacin, Pedro
AU  - Palacin P
FAU - Truche, Anne-Sophie
AU  - Truche AS
FAU - Zaoui, Philippe
AU  - Zaoui P
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Unite de concertation ethique en nephrologie (UCEN) : bilan de fonctionnement a
      dix ans sur le bassin grenoblois.
DEP - 20121221
PL  - France
TA  - Nephrol Ther
JT  - Nephrologie & therapeutique
JID - 101248950
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Decision Making
MH  - *Ethics Consultation
MH  - Humans
MH  - Middle Aged
MH  - Nephrology/*ethics
MH  - Renal Dialysis/*ethics
EDAT- 2012/12/26 06:00
MHDA- 2014/02/14 06:00
CRDT- 2012/12/26 06:00
PHST- 2012/09/01 00:00 [received]
PHST- 2012/10/01 00:00 [revised]
PHST- 2012/10/21 00:00 [accepted]
PHST- 2012/12/26 06:00 [entrez]
PHST- 2012/12/26 06:00 [pubmed]
PHST- 2014/02/14 06:00 [medline]
AID - S1769-7255(12)00579-2 [pii]
AID - 10.1016/j.nephro.2012.10.009 [doi]
PST - ppublish
SO  - Nephrol Ther. 2013 Jul;9(4):222-7. doi: 10.1016/j.nephro.2012.10.009. Epub 2012
      Dec 21.


PMID- 23266167
OWN - NLM
STAT- MEDLINE
DCOM- 20130805
LR  - 20130204
IS  - 1769-664X (Electronic)
IS  - 0929-693X (Linking)
VI  - 20
IP  - 2
DP  - 2013 Feb
TI  - [Ethics practices in mother-and-children's hospitals].
PG  - 119-22
LID - 10.1016/j.arcped.2012.11.015 [doi]
LID - S0929-693X(12)00508-8 [pii]
FAU - Aujard, Y
AU  - Aujard Y
LA  - fre
PT  - Editorial
TT  - La pratique de l'ethique dans les hopitaux mere-enfant.
DEP - 20121221
PL  - France
TA  - Arch Pediatr
JT  - Archives de pediatrie : organe officiel de la Societe francaise de pediatrie
JID - 9421356
SB  - IM
MH  - Ethics Committees
MH  - Hospitals, Maternity/*ethics/organization & administration
MH  - Hospitals, Pediatric/*ethics/organization & administration
MH  - Humans
MH  - Infant, Newborn
EDAT- 2012/12/26 06:00
MHDA- 2013/08/06 06:00
CRDT- 2012/12/26 06:00
PHST- 2012/11/14 00:00 [received]
PHST- 2012/11/14 00:00 [accepted]
PHST- 2012/12/26 06:00 [entrez]
PHST- 2012/12/26 06:00 [pubmed]
PHST- 2013/08/06 06:00 [medline]
AID - S0929-693X(12)00508-8 [pii]
AID - 10.1016/j.arcped.2012.11.015 [doi]
PST - ppublish
SO  - Arch Pediatr. 2013 Feb;20(2):119-22. doi: 10.1016/j.arcped.2012.11.015. Epub 2012
      Dec 21.


PMID- 23265913
OWN - NLM
STAT- MEDLINE
DCOM- 20140403
LR  - 20190429
IS  - 1873-5223 (Electronic)
IS  - 1471-5953 (Linking)
VI  - 13
IP  - 5
DP  - 2013 Sep
TI  - Group marking and peer assessment during a group poster presentation: the
      experiences and views of midwifery students.
PG  - 466-70
LID - 10.1016/j.nepr.2012.11.005 [doi]
LID - S1471-5953(12)00209-0 [pii]
AB  - Traditionally, written examination and clinical practice assessments are the main
      ways of deeming midwifery students fit and competent for practice. Contemporary
      academics in an effort to engage the students in the learning process have
      employed alternative teaching and assessment strategies. Among the alternative
      strategies are group projects after which members of the group are awarded the
      same grade, and peer assessment. With the purpose of informing the midwifery
      curricular, we utilised a qualitative descriptive approach to explore midwifery
      students' experiences and views on the use of group poster presentation for
      learning and assessment. The participants consisted of a purposive sample of 14
      higher diploma midwifery students who were registered in a third level
      institution in Ireland. Semi-structured individual interviews were conducted
      following the completion of the poster presentation assessment. Permission to
      undertake the study was obtained from the college ethics committee. In this
      paper, we focus on the participants' views of group marking and peer assessment
      which are among the key elements that emerged in this study. While awarding a
      group mark was overall accepted, peer assessment proved a more contentious issue.
      Most of the participants found it challenging marking their friends. Reactions to
      group marks were very much influenced by the group dynamics.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Ohaja, Magdalena
AU  - Ohaja M
AD  - School of Nursing and Midwifery, Trinity College Dublin, 24 D'Olier Street,
      Dublin 2, Ireland. ohajam@tcd.ie
FAU - Dunlea, Margaret
AU  - Dunlea M
FAU - Muldoon, Kathryn
AU  - Muldoon K
LA  - eng
PT  - Journal Article
DEP - 20121221
PL  - Scotland
TA  - Nurse Educ Pract
JT  - Nurse education in practice
JID - 101090848
SB  - IM
MH  - Education, Nursing, Diploma Programs
MH  - Educational Measurement/*methods
MH  - Female
MH  - *Group Processes
MH  - Humans
MH  - Ireland
MH  - Midwifery/*education
MH  - Narration
MH  - Nursing Research/*education
MH  - *Peer Group
MH  - *Posters as Topic
MH  - Pregnancy
MH  - Program Evaluation
MH  - Qualitative Research
MH  - Teaching/*methods
OTO - NOTNLM
OT  - Group mark
OT  - Group poster presentation
OT  - Midwifery education
OT  - Peer assessment
EDAT- 2012/12/26 06:00
MHDA- 2014/04/04 06:00
CRDT- 2012/12/26 06:00
PHST- 2012/06/06 00:00 [received]
PHST- 2012/09/28 00:00 [revised]
PHST- 2012/11/30 00:00 [accepted]
PHST- 2012/12/26 06:00 [entrez]
PHST- 2012/12/26 06:00 [pubmed]
PHST- 2014/04/04 06:00 [medline]
AID - S1471-5953(12)00209-0 [pii]
AID - 10.1016/j.nepr.2012.11.005 [doi]
PST - ppublish
SO  - Nurse Educ Pract. 2013 Sep;13(5):466-70. doi: 10.1016/j.nepr.2012.11.005. Epub
      2012 Dec 21.


PMID- 23265411
OWN - NLM
STAT- MEDLINE
DCOM- 20130927
LR  - 20211021
IS  - 1878-5891 (Electronic)
IS  - 0378-5955 (Linking)
VI  - 297
DP  - 2013 Mar
TI  - Gene therapy for the inner ear.
PG  - 99-105
LID - 10.1016/j.heares.2012.11.017 [doi]
LID - S0378-5955(12)00275-4 [pii]
AB  - Animal studies on inner ear development, repair and regeneration provide
      understanding of molecular pathways that can be harnessed for treating inner ear 
      disease. Use of transgenic mouse technology, in particular, has contributed
      knowledge of genes that regulate development of hair cells and innervation, and
      of molecular players that can induce regeneration, but this technology is not
      applicable for human treatment, for practical and ethical reasons. Therefore
      other means for influencing gene expression in the inner ear are needed. We
      describe several gene vectors useful for inner ear gene therapy and the practical
      aspects of introducing these vectors into the ear. We then review the progress
      toward using gene transfer for therapies in both auditory and balance systems,
      and discuss the technological milestones needed to advance to clinical
      application of these methods.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Fukui, Hideto
AU  - Fukui H
AD  - Kresge Hearing Research Institute, Department of Otolaryngology, University of
      Michigan, 1150 West Medical Center Dr., Ann Arbor, MI 48109-5648, USA.
FAU - Raphael, Yehoash
AU  - Raphael Y
LA  - eng
GR  - R01 DC001634/DC/NIDCD NIH HHS/United States
GR  - R21 DC011631/DC/NIDCD NIH HHS/United States
GR  - R01 DC007634/DC/NIDCD NIH HHS/United States
GR  - P30 DC005188/DC/NIDCD NIH HHS/United States
GR  - T32 DC005356/DC/NIDCD NIH HHS/United States
GR  - R55 DC007634/DC/NIDCD NIH HHS/United States
GR  - DC-007634/DC/NIDCD NIH HHS/United States
GR  - DC-010412/DC/NIDCD NIH HHS/United States
GR  - P30 DC-05188/DC/NIDCD NIH HHS/United States
GR  - R01 DC010412/DC/NIDCD NIH HHS/United States
GR  - T32 DC-005356/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20121221
PL  - Netherlands
TA  - Hear Res
JT  - Hearing research
JID - 7900445
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - Ear, Inner/*physiology
MH  - Gene Expression
MH  - Gene Expression Profiling
MH  - Gene Expression Regulation
MH  - Genetic Therapy/*methods
MH  - Genetic Vectors
MH  - Hearing Loss, Sensorineural/*therapy
MH  - Humans
MH  - Labyrinth Diseases/*therapy
MH  - Mice
MH  - Mice, Transgenic
MH  - Nerve Regeneration
MH  - Neurons/physiology
MH  - Signal Transduction
PMC - PMC3594056
MID - NIHMS423590
EDAT- 2012/12/26 06:00
MHDA- 2013/09/28 06:00
CRDT- 2012/12/26 06:00
PHST- 2012/10/10 00:00 [received]
PHST- 2012/11/12 00:00 [accepted]
PHST- 2012/12/26 06:00 [entrez]
PHST- 2012/12/26 06:00 [pubmed]
PHST- 2013/09/28 06:00 [medline]
AID - S0378-5955(12)00275-4 [pii]
AID - 10.1016/j.heares.2012.11.017 [doi]
PST - ppublish
SO  - Hear Res. 2013 Mar;297:99-105. doi: 10.1016/j.heares.2012.11.017. Epub 2012 Dec
      21.


PMID- 23264360
OWN - NLM
STAT- MEDLINE
DCOM- 20141112
LR  - 20130920
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 10
DP  - 2013 Oct
TI  - A plea for end-of-life discussions with patients suffering from Huntington's
      disease: the role of the physician.
PG  - 621-4
LID - 10.1136/medethics-2011-100369 [doi]
AB  - Euthanasia and physician-assisted suicide (PAS) by request and/or based on an
      advance directive are legal in The Netherlands under strict conditions, thus
      providing options for patients with Huntington's disease (HD) and other
      neurodegenerative diseases to stay in control and choose their end of life. HD is
      an inherited progressive disease characterised by chorea and hypokinesia,
      psychiatric symptoms and dementia. From a qualitative study based on interviews
      with 15 physicians experienced in treating HD, several ethical issues emerged.
      Consideration of these aspects leads to a discussion about the professional role 
      of a physician in relation to the personal autonomy of a patient. Such a
      discussion can raise awareness that talking about end-of-life wishes with an HD
      patient is part of the legal, professional and moral responsibility of the
      physician, and that a letter of intent on behalf of the physician can improve
      active participation in the process. Discussion of these issues can help to
      advance the debate on euthanasia and PAS in HD and other neurodegenerative
      diseases.
FAU - Booij, Suzanne J
AU  - Booij SJ
AD  - Department of Neurology, LUMC, , Leiden, The Netherlands.
FAU - Engberts, Dick P
AU  - Engberts DP
FAU - Rodig, Verena
AU  - Rodig V
FAU - Tibben, Aad
AU  - Tibben A
FAU - Roos, Raymund A C
AU  - Roos RA
LA  - eng
PT  - Journal Article
DEP - 20121222
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Advance Directives/ethics/psychology
MH  - Communication
MH  - Euthanasia/ethics/legislation & jurisprudence/psychology
MH  - Humans
MH  - Huntington Disease/*psychology
MH  - Netherlands
MH  - Neurodegenerative Diseases/psychology
MH  - Personal Autonomy
MH  - Physician's Role/*psychology
MH  - Physicians/ethics
MH  - Suicide, Assisted/*ethics/legislation & jurisprudence/psychology
OTO - NOTNLM
OT  - Euthanasia
OT  - Living Wills/Advance Directives
OT  - Neuroethics
EDAT- 2012/12/25 06:00
MHDA- 2014/11/13 06:00
CRDT- 2012/12/25 06:00
PHST- 2012/12/25 06:00 [entrez]
PHST- 2012/12/25 06:00 [pubmed]
PHST- 2014/11/13 06:00 [medline]
AID - medethics-2011-100369 [pii]
AID - 10.1136/medethics-2011-100369 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Oct;39(10):621-4. doi: 10.1136/medethics-2011-100369. Epub
      2012 Dec 22.


PMID- 23264345
OWN - NLM
STAT- MEDLINE
DCOM- 20130625
LR  - 20220316
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 267
IP  - 2
DP  - 2013 May
TI  - Perfusion CT in acute stroke: a comprehensive analysis of infarct and penumbra.
PG  - 543-50
LID - 10.1148/radiol.12120971 [doi]
AB  - PURPOSE: To perform a large-scale systematic comparison of the accuracy of all
      commonly used perfusion computed tomography (CT) data postprocessing methods in
      the definition of infarct core and penumbra in acute stroke. MATERIALS AND
      METHODS: The collection of data for this study was approved by the institutional 
      ethics committee, and all patients gave informed consent. Three hundred fourteen 
      patients with hemispheric ischemia underwent perfusion CT within 6 hours of
      stroke symptom onset and magnetic resonance (MR) imaging at 24 hours. CT
      perfusion maps were generated by using six different postprocessing methods.
      Pixel-based analysis was used to calculate sensitivity and specificity of
      different perfusion CT thresholds for the penumbra and infarct core with each
      postprocessing method, and receiver operator characteristic (ROC) curves were
      plotted. Area under the ROC curve (AUC) analysis was used to define the optimum
      threshold. RESULTS: Delay-corrected singular value deconvolution (SVD) with a
      delay time of more than 2 seconds most accurately defined the penumbra (AUC =
      0.86, P = .046, mean volume difference between acute perfusion CT and 24-hour
      diffusion-weighted MR imaging = 1.7 mL). A double core threshold with a delay
      time of more than 2 seconds and cerebral blood flow less than 40% provided the
      most accurate definition of the infarct core (AUC = 0.86, P = .038). The other
      SVD measures (block circulant, nondelay corrected) were more accurate than
      non-SVD methods. CONCLUSION: This study has shown that there is marked
      variability in penumbra and infarct prediction among various deconvolution
      techniques and highlights the need for standardization of perfusion CT in stroke.
      SUPPLEMENTAL MATERIAL:
      http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.12120971/-/DC1.
CI  - (c) RSNA, 2013.
FAU - Bivard, Andrew
AU  - Bivard A
AD  - Melbourne Brain Centre, University of Melbourne, Melbourne, Victoria 3010,
      Australia. andrew.bivard@unimelb.edu.au
FAU - Levi, Christopher
AU  - Levi C
FAU - Spratt, Neil
AU  - Spratt N
FAU - Parsons, Mark
AU  - Parsons M
LA  - eng
PT  - Journal Article
DEP - 20121221
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - 4419T9MX03 (Iohexol)
RN  - 712BAC33MZ (iopromide)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cerebrovascular Circulation
MH  - Contrast Media
MH  - Female
MH  - Humans
MH  - Iohexol/analogs & derivatives
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - ROC Curve
MH  - Radiographic Image Interpretation, Computer-Assisted
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
MH  - Stroke/*diagnostic imaging
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2012/12/25 06:00
MHDA- 2013/06/26 06:00
CRDT- 2012/12/25 06:00
PHST- 2012/12/25 06:00 [entrez]
PHST- 2012/12/25 06:00 [pubmed]
PHST- 2013/06/26 06:00 [medline]
AID - radiol.12120971 [pii]
AID - 10.1148/radiol.12120971 [doi]
PST - ppublish
SO  - Radiology. 2013 May;267(2):543-50. doi: 10.1148/radiol.12120971. Epub 2012 Dec
      21.


PMID- 23264344
OWN - NLM
STAT- MEDLINE
DCOM- 20130516
LR  - 20220129
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 267
IP  - 1
DP  - 2013 Apr
TI  - Simultaneous imaging of lung structure and function with triple-nuclear hybrid MR
      imaging.
PG  - 251-5
LID - 10.1148/radiol.12121153 [doi]
AB  - PURPOSE: To re-engineer a standard clinical magnetic resonance (MR) imaging
      system to enable the acquisition, in the same breath hold, of lung images from
      two hyperpolarized gases (helium 3 [(3)He] and xenon 129 [(129)Xe]) with
      simultaneous registered anatomic proton (hydrogen 1 [(1)H]) MR images of lung
      structure. MATERIALS AND METHODS: Studies with (3)He and (129)Xe were performed
      with National Research Ethics Committee approval, with informed consent from the 
      volunteer. (1)H-(3)He-(129)Xe MR imaging was achieved in the same breath by using
      mutually decoupled nested radiofrequency coil hardware capable of transmit and
      receive on each respective nucleus without power cross talk. MR pulse sequences
      were also developed for rapid switching between each nucleus. The system is
      demonstrated with triple-nuclear lung images in a healthy individual following
      inhalation of a mixture of (3)He and (129)Xe gases. RESULTS: Spatially and
      temporally registered images of all three nuclei were obtained with high signal
      to noise ratio and high spatial resolution in the same breath. CONCLUSION: The
      multinuclear technique is capable of providing registered lung images with
      mutually complementary functional and structural spatial information.
CI  - RSNA, 2012
FAU - Wild, Jim M
AU  - Wild JM
AD  - Academic Unit of Radiology, University of Sheffield, C Floor, Royal Hallamshire
      Hospital, Glossop Road, Sheffield S10 2JF, England. j.m.wild@shef.ac.uk
FAU - Marshall, Helen
AU  - Marshall H
FAU - Xu, Xiaoxun
AU  - Xu X
FAU - Norquay, Graham
AU  - Norquay G
FAU - Parnell, Steven R
AU  - Parnell SR
FAU - Clemence, Matthew
AU  - Clemence M
FAU - Griffiths, Paul D
AU  - Griffiths PD
FAU - Parra-Robles, Juan
AU  - Parra-Robles J
LA  - eng
GR  - NIHR-RP-R3-12-027/DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121221
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 206GF3GB41 (Helium)
RN  - 3H3U766W84 (Xenon)
SB  - IM
MH  - *Helium
MH  - Humans
MH  - Lung/*anatomy & histology/*physiology
MH  - Magnetic Resonance Imaging/instrumentation/*methods
MH  - *Xenon
EDAT- 2012/12/25 06:00
MHDA- 2013/05/17 06:00
CRDT- 2012/12/25 06:00
PHST- 2012/12/25 06:00 [entrez]
PHST- 2012/12/25 06:00 [pubmed]
PHST- 2013/05/17 06:00 [medline]
AID - radiol.12121153 [pii]
AID - 10.1148/radiol.12121153 [doi]
PST - ppublish
SO  - Radiology. 2013 Apr;267(1):251-5. doi: 10.1148/radiol.12121153. Epub 2012 Dec 21.


PMID- 23263902
OWN - NLM
STAT- MEDLINE
DCOM- 20140122
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 3
DP  - 2013 Sep
TI  - European public deliberation on brain machine interface technology: five
      convergence seminars.
PG  - 1071-86
LID - 10.1007/s11948-012-9425-0 [doi]
AB  - We present a novel procedure to engage the public in ethical deliberations on the
      potential impacts of brain machine interface technology. We call this procedure a
      convergence seminar, a form of scenario-based group discussion that is founded on
      the idea of hypothetical retrospection. The theoretical background of this
      procedure and the results of five seminars are presented.
FAU - Jebari, Karim
AU  - Jebari K
AD  - Royal Institute of Technology, Stockholm, Sweden. Jebari@kth.se
FAU - Hansson, Sven-Ove
AU  - Hansson SO
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121222
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Brain-Computer Interfaces/*ethics
MH  - *Community Participation
MH  - Congresses as Topic
MH  - Europe
MH  - Group Processes
MH  - Humans
MH  - Technology/*ethics
EDAT- 2012/12/25 06:00
MHDA- 2014/01/23 06:00
CRDT- 2012/12/25 06:00
PHST- 2012/09/27 00:00 [received]
PHST- 2012/12/10 00:00 [accepted]
PHST- 2012/12/25 06:00 [entrez]
PHST- 2012/12/25 06:00 [pubmed]
PHST- 2014/01/23 06:00 [medline]
AID - 10.1007/s11948-012-9425-0 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Sep;19(3):1071-86. doi: 10.1007/s11948-012-9425-0. Epub 2012
      Dec 22.


PMID- 23263492
OWN - NLM
STAT- MEDLINE
DCOM- 20140113
LR  - 20211021
IS  - 1437-160X (Electronic)
IS  - 0172-8172 (Linking)
VI  - 33
IP  - 6
DP  - 2013 Jun
TI  - Adhesive capsulitis: one sonographic-guided injection of 20 mg triamcinolon into 
      the rotator interval.
PG  - 1547-53
LID - 10.1007/s00296-012-2503-4 [doi]
AB  - The aim of this study was to establish a method for injecting corticosteroid into
      the rotator interval under sonographic guidance and to measure the effect on
      function, pain and range of motion after 4 and 12 weeks. This study involved a
      multicenter cohort trial and carried out at outpatient clinics of the physical
      medicine and rehabilitation departments in Oslo and Porsgrunn, Norway. 39
      patients with adhesive capsulitis lasting between 3 and 12 months.
      Sonographic-guided corticosteroid and lidocaine injection into the rotator
      interval medial to the biceps tendon using 20 mg triamcinolon hexacetat and 3 ml 
      20 mg/ml xylocain. Change in the shoulder pain and disability index score (SPADI)
      after 12 weeks. The change in SPADI was 42 points (95 % confidence interval,
      33-51). Changes in the secondary outcomes shoved highly statistically significant
      increase in active and passive range of motion. One ultrasound-guided
      corticosteroid injection into the rotator interval seems to give significant
      improvement in SPADI and active range of motion after 12 weeks. The protocol was 
      evaluated by the research faculty at Oslo university hospital, dept of physical
      medicine. The study was regarded as regular clinical procedure as injections with
      triamcinolon already is standard treatment. No trial registration was obtained
      but the protocol presented the local ethics committee without comments.
FAU - Juel, Niels Gunnar
AU  - Juel NG
AD  - Department for Physical Medicine and Rehabilitation, Oslo University Hospital,
      Ulleval, Oslo, Norway. n_gj@hotmail.com
FAU - Oland, Gunnar
AU  - Oland G
FAU - Kvalheim, Synnove
AU  - Kvalheim S
FAU - Love, Tormod
AU  - Love T
FAU - Ekeberg, Ole Marius
AU  - Ekeberg OM
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
DEP - 20121222
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
RN  - 0 (Anti-Inflammatory Agents)
RN  - 1ZK20VI6TY (Triamcinolone)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Anti-Inflammatory Agents/*administration & dosage
MH  - Bursitis/*drug therapy
MH  - Female
MH  - Humans
MH  - Injections, Intra-Articular
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Rotator Cuff
MH  - Triamcinolone/*administration & dosage
MH  - *Ultrasonography, Interventional
EDAT- 2012/12/25 06:00
MHDA- 2014/01/15 06:00
CRDT- 2012/12/25 06:00
PHST- 2012/01/19 00:00 [received]
PHST- 2012/08/23 00:00 [accepted]
PHST- 2012/12/25 06:00 [entrez]
PHST- 2012/12/25 06:00 [pubmed]
PHST- 2014/01/15 06:00 [medline]
AID - 10.1007/s00296-012-2503-4 [doi]
PST - ppublish
SO  - Rheumatol Int. 2013 Jun;33(6):1547-53. doi: 10.1007/s00296-012-2503-4. Epub 2012 
      Dec 22.


PMID- 23263019
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121225
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 6
DP  - 2012
TI  - The ethics of unlinked anonymous testing of blood: views from in-depth interviews
      with key informants in four countries.
LID - 10.1136/bmjopen-2012-001427 [doi]
LID - e001427 [pii]
AB  - OBJECTIVES: In this study we explore the ethical issues around unlinked anonymous
      testing (UAT) of blood, a method of seroprevalence surveillance for infectious
      diseases. Our study focused on UAT for HIV, although UAT can be used for other
      infectious diseases. The objectives of the research were to gain a better
      understanding of the views of key informants in countries adopting different UAT 
      testing strategies, and to use the findings of the research to inform health
      policy. DESIGN: Qualitative study using in-depth interviews and ethical analysis.
      SETTING: Four countries using different strategies around UAT of blood for HIV
      (the UK, the USA, the Netherlands and Norway). PARTICIPANTS: Twenty-three key
      informants in the four countries. RESULTS: Participants from the four countries
      have different views on UAT of blood, and the approaches and policies on UAT
      adopted by different countries have been historically and culturally determined. 
      We use our findings to explore the relationship between public health policy and 
      ethics, framing our discussion in relation to two important contemporary debates:
      informed consent for participation in medical and public health research; and the
      balance between the individual good and the public good. CONCLUSIONS: Qualitative
      research and ethical analysis of UAT of blood in different countries has yielded 
      important findings for consideration by policy makers. The policy of UAT of blood
      for HIV and other diseases in the UK needs reconsideration in the light of these 
      findings.
FAU - Kessel, Anthony S
AU  - Kessel AS
AD  - Department of Social and Environmental Health Research, London School of Hygiene 
      and Tropical Medicine, London, UK.
FAU - Datta, Jessica
AU  - Datta J
FAU - Wellings, Kaye
AU  - Wellings K
FAU - Perman, Sarah
AU  - Perman S
LA  - eng
PT  - Journal Article
DEP - 20121220
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3532979
EDAT- 2012/12/25 06:00
MHDA- 2012/12/25 06:01
CRDT- 2012/12/25 06:00
PHST- 2012/12/25 06:00 [entrez]
PHST- 2012/12/25 06:00 [pubmed]
PHST- 2012/12/25 06:01 [medline]
AID - bmjopen-2012-001427 [pii]
AID - 10.1136/bmjopen-2012-001427 [doi]
PST - epublish
SO  - BMJ Open. 2012 Dec 20;2(6). pii: bmjopen-2012-001427. doi:
      10.1136/bmjopen-2012-001427. Print 2012.


PMID- 23262764
OWN - NLM
STAT- MEDLINE
DCOM- 20130626
LR  - 20220309
IS  - 1527-1927 (Electronic)
IS  - 0361-6878 (Linking)
VI  - 38
IP  - 2
DP  - 2013 Apr
TI  - Motherhood preconceived: the emergence of the Preconception Health and Health
      Care Initiative.
PG  - 345-71
LID - 10.1215/03616878-1966333 [doi]
AB  - Since the 1980s, maternal and child health experts have sought to redefine
      maternity care to include the period prior to pregnancy, essentially by expanding
      the concept of prenatal care to encompass the time before conception. In 2004,
      the Centers for Disease Control and Prevention endorsed and promoted this new
      definition when it launched the Preconception Health and Health Care Initiative. 
      In arguing that prenatal care was often too little too late, a group of maternal 
      and child health experts in the United States attempted to spur improvements in
      population health and address systemic problems in health care access and health 
      disparities. By changing the terms of pregnancy risk and by using maternalism as 
      a social policy strategy, the preconception health and health care paradigm
      promoted an ethic of anticipatory motherhood and conflated women's health with
      maternal health, sparking public debate about the potential social and clinical
      consequences of preconception care. This article tracks the construction of this 
      policy idea and its ultimate potential utility in health and health policy
      discussions.
FAU - Waggoner, Miranda R
AU  - Waggoner MR
AD  - Princeton University, USA.
LA  - eng
GR  - R24 HD047879/HD/NICHD NIH HHS/United States
GR  - T32 HD007163/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20121221
PL  - United States
TA  - J Health Polit Policy Law
JT  - Journal of health politics, policy and law
JID - 7609331
SB  - IM
MH  - Centers for Disease Control and Prevention, U.S.
MH  - Female
MH  - *Health Policy
MH  - Humans
MH  - *Policy Making
MH  - *Preconception Care
MH  - United States
PMC - PMC3656594
MID - NIHMS464103
EDAT- 2012/12/25 06:00
MHDA- 2013/06/28 06:00
CRDT- 2012/12/25 06:00
PHST- 2012/12/25 06:00 [entrez]
PHST- 2012/12/25 06:00 [pubmed]
PHST- 2013/06/28 06:00 [medline]
AID - 03616878-1966333 [pii]
AID - 10.1215/03616878-1966333 [doi]
PST - ppublish
SO  - J Health Polit Policy Law. 2013 Apr;38(2):345-71. doi: 10.1215/03616878-1966333. 
      Epub 2012 Dec 21.


PMID- 23262566
OWN - NLM
STAT- MEDLINE
DCOM- 20130211
LR  - 20181023
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 345
DP  - 2012 Dec 21
TI  - What hope is there for ethical investment?
PG  - e8549
LID - 10.1136/bmj.e8549 [doi]
LID - bmj.e8549 [pii]
FAU - Sidebotham, Peter
AU  - Sidebotham P
LA  - eng
PT  - Letter
DEP - 20121221
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
SB  - IM
MH  - Commerce/*ethics
MH  - Financial Management/*ethics
MH  - Humans
MH  - Investments/*ethics
MH  - Public Health/*ethics
MH  - Tobacco
MH  - United Kingdom
EDAT- 2012/12/25 06:00
MHDA- 2013/02/12 06:00
CRDT- 2012/12/25 06:00
PHST- 2012/12/25 06:00 [entrez]
PHST- 2012/12/25 06:00 [pubmed]
PHST- 2013/02/12 06:00 [medline]
AID - 10.1136/bmj.e8549 [doi]
PST - epublish
SO  - BMJ. 2012 Dec 21;345:e8549. doi: 10.1136/bmj.e8549.


PMID- 23261234
OWN - NLM
STAT- MEDLINE
DCOM- 20140314
LR  - 20130816
IS  - 1879-0518 (Electronic)
IS  - 0010-7824 (Linking)
VI  - 88
IP  - 3
DP  - 2013 Sep
TI  - Antenatal contraception - simple, feasible, but is it safe and ethical in
      resource-poor environments?
PG  - 337-40
LID - 10.1016/j.contraception.2012.11.003 [doi]
LID - S0010-7824(12)00973-0 [pii]
AB  - In developing countries, antenatal care is used by more women than any other
      reproductive health services available and many women who receive antenatal care 
      will not receive intrapartum care by a trained provider and even fewer will
      receive postnatal care. At present, antenatal care provides contraceptive
      counselling but not contraceptive provision. An important reason for this is the 
      perceived absence of a suitable method that could be distributed or started
      during antenatal care. In this article, we discuss the available options. We
      conclude that antenatal insertion of subdermal contraceptive implants is very
      likely to be safe and ethically defensible where access to contraceptive services
      is poor.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Pittrof, Rudiger
AU  - Pittrof R
AD  - Community Reproductive and Sexual Health, London, UK. rudiger.pittrof@gstt.nhs.uk
FAU - Filippi, Veronique
AU  - Filippi V
FAU - Some, Der Adolphe
AU  - Some DA
FAU - Compaore, Georges
AU  - Compaore G
FAU - Meda, Nicolas
AU  - Meda N
LA  - eng
PT  - Journal Article
DEP - 20121220
PL  - United States
TA  - Contraception
JT  - Contraception
JID - 0234361
RN  - 0 (Contraceptive Agents, Female)
RN  - 5W7SIA7YZW (Levonorgestrel)
SB  - IM
MH  - Administration, Cutaneous
MH  - Adolescent
MH  - Adult
MH  - Contraception/ethics/methods
MH  - Contraception Behavior
MH  - Contraceptive Agents, Female/*administration & dosage/adverse effects
MH  - *Developing Countries
MH  - Female
MH  - Health Services Accessibility
MH  - Humans
MH  - Levonorgestrel/administration & dosage/adverse effects/blood
MH  - Middle Aged
MH  - Pregnancy
MH  - *Prenatal Care
MH  - Young Adult
OTO - NOTNLM
OT  - Antenatal
OT  - Developing countries
OT  - Subdermal implant
EDAT- 2012/12/25 06:00
MHDA- 2014/03/15 06:00
CRDT- 2012/12/25 06:00
PHST- 2012/10/12 00:00 [received]
PHST- 2012/10/20 00:00 [revised]
PHST- 2012/11/02 00:00 [accepted]
PHST- 2012/12/25 06:00 [entrez]
PHST- 2012/12/25 06:00 [pubmed]
PHST- 2014/03/15 06:00 [medline]
AID - S0010-7824(12)00973-0 [pii]
AID - 10.1016/j.contraception.2012.11.003 [doi]
PST - ppublish
SO  - Contraception. 2013 Sep;88(3):337-40. doi: 10.1016/j.contraception.2012.11.003.
      Epub 2012 Dec 20.


PMID- 23260628
OWN - NLM
STAT- MEDLINE
DCOM- 20130711
LR  - 20181202
IS  - 1769-6623 (Electronic)
IS  - 0750-7658 (Linking)
VI  - 32
IP  - 1
DP  - 2013 Jan
TI  - [Single-dose intraincisional levobupivacaine infiltration in caesarean
      postoperative analgesia: a placebo-controlled double-blind randomized trial].
PG  - 25-30
LID - 10.1016/j.annfar.2012.10.035 [doi]
LID - S0750-7658(12)00482-0 [pii]
AB  - OBJECTIVES: The efficacy of single-dose intraincisional infiltration with
      levobupivacaine in postoperative analgesia and chronic pain after caesarean
      sections is unknown. STUDY: A placebo-controlled double-blind randomized trial.
      PATIENTS AND METHODS: After ethical approval, and written inform consent, 140
      women scheduled for a caesarean section were randomly assigned and received 30mL 
      of levobupivacaine 0.5% (L group) or saline (placebo-P group) into their wound.
      The primary endpoint was morphine consumption (using intravenous morphine
      patient-controlled analgesia) for the first 24h after surgery. At 1h to 48h, side
      effects, pain at rest and pain 2months later were recorded. RESULTS: All included
      patients had similar demographic and surgical characteristics. The morphine
      consumption was significantly lower in the L group at h6, h8 and h12 (considering
      both total intake and each request). At h4, the mean total morphine consumption
      was 25 (12) mg in the L group versus 31 (14) mg in the P group (P=0.05). Time
      until discharge and side effects including nausea-vomiting (14 vs 20%), wound
      scar complications (6 vs 8%) and chronic pain after 2months (25% in both groups
      complained of small pain, and 75% no pain) were similar between the two groups
      (P>0.05). CONCLUSION: Single-dose local infiltration of levobupivacaine 0.5%
      reduced opioid requirement at 12h, with no difference after 24h.
      www.clinicaltrials.com, number: NCT00621907.
CI  - Copyright (c) 2012 Societe francaise d'anesthesie et de reanimation (Sfar).
      Published by Elsevier SAS. All rights reserved.
FAU - Corsini, T
AU  - Corsini T
AD  - Departement de gynecologie-obstetrique, CHU de Saint-Etienne, 42055 Saint-Etienne
      cedex 2, France.
FAU - Cuvillon, P
AU  - Cuvillon P
FAU - Forgeot, A
AU  - Forgeot A
FAU - Chapelle, C
AU  - Chapelle C
FAU - Seffert, P
AU  - Seffert P
FAU - Chauleur, C
AU  - Chauleur C
LA  - fre
SI  - ClinicalTrials.gov/NCT00621907
PT  - Journal Article
PT  - Randomized Controlled Trial
TT  - Infiltration peroperatoire de levobupivacaine apres cesariennes: etude randomisee
      en double insu contre placebo.
DEP - 20121221
PL  - France
TA  - Ann Fr Anesth Reanim
JT  - Annales francaises d'anesthesie et de reanimation
JID - 8213275
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Anesthetics, Local)
RN  - 76I7G6D29C (Morphine)
RN  - A5H73K9U3W (Levobupivacaine)
RN  - Y8335394RO (Bupivacaine)
SB  - IM
MH  - Adult
MH  - Analgesics, Opioid/administration & dosage/therapeutic use
MH  - Anesthetics, Local/administration & dosage/*therapeutic use
MH  - Bupivacaine/administration & dosage/analogs & derivatives/therapeutic use
MH  - *Cesarean Section
MH  - Double-Blind Method
MH  - Endpoint Determination
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Levobupivacaine
MH  - Morphine/administration & dosage/therapeutic use
MH  - Pain Measurement
MH  - Pain, Postoperative/*drug therapy
MH  - Parity
MH  - Postoperative Nausea and Vomiting/epidemiology
MH  - Pregnancy
EDAT- 2012/12/25 06:00
MHDA- 2013/07/13 06:00
CRDT- 2012/12/25 06:00
PHST- 2011/12/18 00:00 [received]
PHST- 2012/10/23 00:00 [accepted]
PHST- 2012/12/25 06:00 [entrez]
PHST- 2012/12/25 06:00 [pubmed]
PHST- 2013/07/13 06:00 [medline]
AID - S0750-7658(12)00482-0 [pii]
AID - 10.1016/j.annfar.2012.10.035 [doi]
PST - ppublish
SO  - Ann Fr Anesth Reanim. 2013 Jan;32(1):25-30. doi: 10.1016/j.annfar.2012.10.035.
      Epub 2012 Dec 21.


PMID- 23260612
OWN - NLM
STAT- MEDLINE
DCOM- 20130522
LR  - 20211021
IS  - 1876-7583 (Electronic)
IS  - 1876-7583 (Linking)
VI  - 6
IP  - 1
DP  - 2013 Jan
TI  - The process associated with motivation of a home-based Wii Fit exercise program
      among sedentary African American women with systemic lupus erythematosus.
PG  - 63-8
LID - 10.1016/j.dhjo.2012.08.003 [doi]
LID - S1936-6574(12)00115-X [pii]
AB  - OBJECTIVE: To explore the process associated with the motivation for playing Wii 
      Fit among patients with systemic lupus erythematosus (SLE). METHODS: Individual
      in-depth semi-structured telephone interviews were conducted with 14 sedentary
      African American women with SLE to explore their experiences and reflect on their
      motivation for playing Wii Fit after completing a 10-week home-based Wii Fit
      exercise program. Interviews were audio-recorded, transcribed verbatim, and
      analyzed using the constant comparative method to identify categories related to 
      participants' motivation. Three authors independently sorted, organized and coded
      transcript text into categories, then combined the categories into themes and
      subthemes. RESULTS: In addition to the two themes (Ethical principal of keeping a
      commitment, and Don't want to let anyone down) generic to home-based exercise
      trials, we identified five themes (Enjoyment, Health Benefits, Sense of
      Accomplishment, Convenience, and Personalized) that revealed why the participants
      were motivated to play the Wii Fit. Enjoyment had three subthemes: Interactive,
      Challenging, and Competitive with an embedded social element. However, several
      participants commented they were not able to do many activities, master certain
      games, or figure out how to play some; as a result, they were bored with the
      limited selection of activities that they could do. CONCLUSIONS: The motivational
      elements of the Wii Fit may contribute to improved exercise motivation and
      adherence in select sedentary African American women with SLE. Results provide a 
      better understanding on the important elements to incorporate in the development 
      of sustainable home-based exercise programs with interactive health video games
      for this population.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Yuen, Hon K
AU  - Yuen HK
AD  - Department of Occupational Therapy, School of Health Professions, University of
      Alabama at Birmingham, Birmingham, AL 35294, USA. yuen@uab.edu
FAU - Breland, Hazel L
AU  - Breland HL
FAU - Vogtle, Laura K
AU  - Vogtle LK
FAU - Holthaus, Katy
AU  - Holthaus K
FAU - Kamen, Diane L
AU  - Kamen DL
FAU - Sword, David
AU  - Sword D
LA  - eng
GR  - UL1 RR029882/RR/NCRR NIH HHS/United States
GR  - UL1 TR000062/TR/NCATS NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
DEP - 20120930
PL  - United States
TA  - Disabil Health J
JT  - Disability and health journal
JID - 101306633
SB  - IM
MH  - Adult
MH  - African Americans
MH  - Aged
MH  - *Exercise
MH  - *Exercise Therapy
MH  - Fatigue/etiology/therapy
MH  - Female
MH  - Humans
MH  - Interviews as Topic
MH  - Lupus Erythematosus, Systemic/complications/*therapy
MH  - Middle Aged
MH  - *Motivation
MH  - *Patient Compliance
MH  - *Sedentary Behavior
MH  - *Video Games
PMC - PMC3539138
MID - NIHMS406721
EDAT- 2012/12/25 06:00
MHDA- 2013/05/23 06:00
CRDT- 2012/12/25 06:00
PHST- 2012/01/14 00:00 [received]
PHST- 2012/06/14 00:00 [revised]
PHST- 2012/08/30 00:00 [accepted]
PHST- 2012/12/25 06:00 [entrez]
PHST- 2012/12/25 06:00 [pubmed]
PHST- 2013/05/23 06:00 [medline]
AID - S1936-6574(12)00115-X [pii]
AID - 10.1016/j.dhjo.2012.08.003 [doi]
PST - ppublish
SO  - Disabil Health J. 2013 Jan;6(1):63-8. doi: 10.1016/j.dhjo.2012.08.003. Epub 2012 
      Sep 30.


PMID- 23259991
OWN - NLM
STAT- MEDLINE
DCOM- 20131105
LR  - 20211203
IS  - 1478-9523 (Electronic)
IS  - 1478-9515 (Linking)
VI  - 11
IP  - 2
DP  - 2013 Apr
TI  - Making "ethical safe space" in the translation of contested knowledge: the role
      of community debate in defining end-of-life decision ethics.
PG  - 123-33
LID - 10.1017/S1478951512000806 [doi]
AB  - OBJECTIVE: The objectives of this article are, first, to document a unique
      process of research knowledge translation (KT), which the authors describe as the
      creation of "ethical safe space," and, second, to document the narratives of
      forum participants and describe their interaction in a dialogue about
      vulnerability, the authority of physicians, and the perspective of people with
      disabilities on the policy. METHOD: Narrative data from qualitative interviews
      with individual key informants and focus groups were used to identify speakers
      with specific expertise on policy, disability perspectives, and bioethical
      issues, who were invited to participate in the Forum on Ethical Safe Space. The
      planning workgroup adopted a model for enabling representative participation in
      the public forum designed to reduce the impact of physical, sensory, financial,
      language, and professional status barriers. Using the transcripts and keynote
      speakers' printed texts, primary themes and patterns of interaction were
      identified reflecting the alternative perspectives. Through the development of a 
      workshop on ethical, legal, and disability-related implications of professional
      policy guidelines developed by the College of Physicians and Surgeons of
      Manitoba, we provided a qualitative analysis of the discourse involving experts
      and disability community members supporting alternative positions on the impact
      of the policy statement, and discuss ethical, legal, and disability rights issues
      identified in the public debate. RESULTS: Contested policy and ethical frameworks
      for making decisions about withdrawing and withholding life supporting treatment 
      may influence both the perspectives of palliative care providers and patients
      referred to palliative care facilities. An innovative model for KT using a public
      forum that enabled stakeholders with conflicting perspectives to engage with
      ethical and professional policy issues asserting the physician's authority in
      contested decisions involving withdrawing or withholding life-supporting
      treatment, was a successful way to engage stakeholders supporting alternative
      positions on the impact of the policy statement and to discuss ethical, legal,
      and disability rights issues identified in the public debate. SIGNIFICANCE OF
      RESULTS: Discussion during the forum revealed several benefits of creating
      ethical safe space. This model of workshop allows space for participation of
      stakeholders, who might not otherwise be able to interact in the same forum, to
      articulate their perspectives and debate with other presenters and audience
      members. Participants at the forum spoke of the creation of ethical safe space as
      a starting point for more dialogue on the issues raised by the policy statement. 
      The forum was, therefore, seen as a potential starting point for building
      conversation that would facilitate revising the policy with broader consultation 
      on its legal and ethical validity.
FAU - Kaufert, Joseph
AU  - Kaufert J
AD  - Department of Community Health Sciences, Faculty of Medicine, University of
      Manitoba, Winnipeg, Canada. kaufertj@cc.umanitoba.ca
FAU - Schwartz, Karen
AU  - Schwartz K
FAU - Wiebe, Rhonda
AU  - Wiebe R
FAU - Derksen, Jim
AU  - Derksen J
FAU - Lutfiyya, Zana M
AU  - Lutfiyya ZM
FAU - Richert, Dean
AU  - Richert D
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121221
PL  - England
TA  - Palliat Support Care
JT  - Palliative & supportive care
JID - 101232529
SB  - IM
MH  - *Bioethical Issues
MH  - *Decision Making
MH  - Focus Groups
MH  - Humans
MH  - Interviews as Topic
MH  - Terminal Care/*ethics
MH  - Translational Research, Biomedical
EDAT- 2012/12/25 06:00
MHDA- 2013/11/06 06:00
CRDT- 2012/12/25 06:00
PHST- 2012/12/25 06:00 [entrez]
PHST- 2012/12/25 06:00 [pubmed]
PHST- 2013/11/06 06:00 [medline]
AID - S1478951512000806 [pii]
AID - 10.1017/S1478951512000806 [doi]
PST - ppublish
SO  - Palliat Support Care. 2013 Apr;11(2):123-33. doi: 10.1017/S1478951512000806. Epub
      2012 Dec 21.


PMID- 23259817
OWN - NLM
STAT- MEDLINE
DCOM- 20130617
LR  - 20211021
IS  - 1472-6920 (Electronic)
IS  - 1472-6920 (Linking)
VI  - 12
DP  - 2012 Dec 22
TI  - Students' view upon graduation: a survey of medical education in Taiwan.
PG  - 127
LID - 10.1186/1472-6920-12-127 [doi]
AB  - BACKGROUND: Improving the quality of medical education is a key goal of
      government policy in Taiwan. The aim of this study was to reflect the responses
      of medical education from the perspective of graduating medical students in
      Taiwan. This is the first survey study of medical education in Taiwan. METHODS:
      Using the Medical School Graduation Questionnaire from the Association of
      American Medical Colleges (AAMC), we distributed 406 questionnaires to medical
      students of four medical schools in their last semester, and received 270 back
      (response rate, 66.5%). There were 11 medical schools in Taiwan. Most questions
      were assessed on a 5-point Likert scale. RESULTS: Students identified genetics,
      biochemistry, and ethics as the three most important premedical subjects
      preparing them for medical education and gross anatomy, physiology, and
      pharmacology as the three most helpful basic science subjects preparing them for 
      clinical clerkships and electives. Most Taiwanese students were satisfied with
      their learning experience in internal medicine. Only 55.9% of students were
      confident that they had acquired the clinical skills required to become a
      resident, and 70.7% were satisfied with the quality of their medical education.
      CONCLUSION: The study offers preliminary results on the views of graduating
      students on the medical education system in Taiwan. In particular, our government
      and medical educators need to continuously put more effort into building
      students' confidence in their clinical skills.
FAU - Chan, Wing P
AU  - Chan WP
AD  - Department of Radiology, Wan Fang Hospital, Taipei Medical University, Taipei,
      Taiwan. wingchan@tmu.edu.tw
FAU - Wu, Ting-Yu
AU  - Wu TY
FAU - Hsieh, Ming-Shium
AU  - Hsieh MS
FAU - Chou, Ting-Ywan
AU  - Chou TY
FAU - Wong, Chih-Shung
AU  - Wong CS
FAU - Fang, Ji-Tseng
AU  - Fang JT
FAU - Chang, Nen-Chung
AU  - Chang NC
FAU - Hong, Chuang-Ye
AU  - Hong CY
FAU - Tzeng, Chii-Ruey
AU  - Tzeng CR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121222
PL  - England
TA  - BMC Med Educ
JT  - BMC medical education
JID - 101088679
SB  - IM
MH  - *Consumer Behavior
MH  - Education, Medical, Undergraduate/*standards
MH  - Female
MH  - Humans
MH  - Male
MH  - Self Efficacy
MH  - Students, Medical/*psychology
MH  - Surveys and Questionnaires
MH  - Taiwan
PMC - PMC3546303
EDAT- 2012/12/25 06:00
MHDA- 2013/06/19 06:00
CRDT- 2012/12/25 06:00
PHST- 2011/11/01 00:00 [received]
PHST- 2012/12/13 00:00 [accepted]
PHST- 2012/12/25 06:00 [entrez]
PHST- 2012/12/25 06:00 [pubmed]
PHST- 2013/06/19 06:00 [medline]
AID - 1472-6920-12-127 [pii]
AID - 10.1186/1472-6920-12-127 [doi]
PST - epublish
SO  - BMC Med Educ. 2012 Dec 22;12:127. doi: 10.1186/1472-6920-12-127.


PMID- 23259150
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121224
LR  - 20211021
IS  - 2090-0597 (Electronic)
IS  - 2090-0597 (Linking)
VI  - 2012
DP  - 2012
TI  - Management of advanced heart failure in the elderly: ethics, economics, and
      resource allocation in the technological era.
PG  - 524961
LID - 10.1155/2012/524961 [doi]
AB  - Significant strides have been made in the durability, portability, and safety of 
      mechanical circulatory support devices (MCS). Although transplant is considered
      the standard treatment for advanced heart failure, limits in organ availability
      leave a much larger pool of recipients in need versus donors. MCS is used as
      bridge to transplantation and as destination therapy (DT) for patients who will
      have MCS as their final invasive therapy with transplant not being an option.
      Despite improvements in quality of life (QOL) and survival, defining the optimal 
      candidate for DT may raise questions regarding the economics of this approach as 
      well as ethical concerns regarding just distribution of goods and services. This 
      paper highlights some of the key ethical issues related to justice and the costs 
      of life-prolonging therapies with respect to resource allocations. Available
      literature, current debates, and future directions are discussed herein.
FAU - Swetz, Keith M
AU  - Swetz KM
AD  - Division of General Internal Medicine, Department of Medicine, Section of
      Palliative Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
FAU - Stulak, John M
AU  - Stulak JM
FAU - Dunlay, Shannon M
AU  - Dunlay SM
FAU - Gafford, Ellin F
AU  - Gafford EF
LA  - eng
PT  - Journal Article
DEP - 20121205
PL  - United States
TA  - Cardiol Res Pract
JT  - Cardiology research and practice
JID - 101516542
PMC - PMC3521420
EDAT- 2012/12/22 06:00
MHDA- 2012/12/22 06:01
CRDT- 2012/12/22 06:00
PHST- 2012/10/14 00:00 [received]
PHST- 2012/11/21 00:00 [accepted]
PHST- 2012/12/22 06:00 [entrez]
PHST- 2012/12/22 06:00 [pubmed]
PHST- 2012/12/22 06:01 [medline]
AID - 10.1155/2012/524961 [doi]
PST - ppublish
SO  - Cardiol Res Pract. 2012;2012:524961. doi: 10.1155/2012/524961. Epub 2012 Dec 5.


PMID- 23259021
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121224
LR  - 20211021
IS  - 1925-8348 (Print)
IS  - 1925-8348 (Linking)
VI  - 15
IP  - 3
DP  - 2012 Sep
TI  - A review of barriers and enablers to diagnosis and management of persons with
      dementia in primary care.
PG  - 85-94
LID - 10.5770/cgj.15.42 [doi]
AB  - BACKGROUND: With the rise in the prevalence of dementia disorders and the growing
      critical impact of dementia on health-care resources, the provision of dementia
      care has increasingly come under scrutiny, with primary care physicians (PCP)
      being at the centre of such attention. PURPOSE: To critically examine barriers
      and enablers to timely diagnosis and optimal management of community living
      persons with dementia (PWD) in primary care. METHODS: An interpretive scoping
      review was used to synthesize and analyze an extensive body of heterogeneous
      Western literature published over the past decade. RESULTS: The current primary
      care systems in many Western countries, including Canada, face many challenges in
      providing responsive, comprehensive, safe, and cost-effective dementia care. This
      paper has identified a multitude of highly inter-related obstacles to optimal
      primary dementia care, including challenges related to: a) the complex
      biomedical, psychosocial, and ethical nature of the condition; b) the gaps in
      knowledge, skills, attitudes, and resources of PWD/caregivers and their primary
      care providers; and c) the broader systemic and structural barriers negatively
      affecting the context of dementia care. CONCLUSIONS: Further progress will
      require a coordinated campaign and significantly increased levels of commitment
      and effort, which should be ideally orchestrated by national dementia strategies 
      focusing on the barriers and enablers identified in this paper.
FAU - Aminzadeh, Faranak
AU  - Aminzadeh F
AD  - Regional Geriatric Program of Eastern Ontario (RGPEO), Bruyere Research Institute
      (BRI), and School of Nursing, University of Ottawa, Ottawa, ON;
FAU - Molnar, Frank J
AU  - Molnar FJ
FAU - Dalziel, William B
AU  - Dalziel WB
FAU - Ayotte, Debbie
AU  - Ayotte D
LA  - eng
PT  - Journal Article
DEP - 20120920
PL  - Canada
TA  - Can Geriatr J
JT  - Canadian geriatrics journal : CGJ
JID - 101579189
PMC - PMC3521322
OTO - NOTNLM
OT  - dementia
OT  - diagnosis and management
OT  - health-care utilization
OT  - intervention studies
OT  - primary care
EDAT- 2012/12/22 06:00
MHDA- 2012/12/22 06:01
CRDT- 2012/12/22 06:00
PHST- 2012/12/22 06:00 [entrez]
PHST- 2012/12/22 06:00 [pubmed]
PHST- 2012/12/22 06:01 [medline]
AID - 10.5770/cgj.15.42 [doi]
AID - cgj-15-85 [pii]
PST - ppublish
SO  - Can Geriatr J. 2012 Sep;15(3):85-94. doi: 10.5770/cgj.15.42. Epub 2012 Sep 20.


PMID- 23259020
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121224
LR  - 20211021
IS  - 1925-8348 (Print)
IS  - 1925-8348 (Linking)
VI  - 15
IP  - 3
DP  - 2012 Sep
TI  - Hypovitaminosis d: a contributor to psychiatric disorders in elderly?
PG  - 80-4
LID - 10.5770/cgj.15.39 [doi]
AB  - BACKGROUND: Hypovitaminosis D is unrecognized and remarkably common in geriatric 
      patients, with various clinical manifestations. The purpose of this study was to 
      prospectively assess the vitamin D (VD) status in newly admitted psychogeriatric 
      patients, and to study the correlation of VD status with indicators of calcium
      metabolism. METHODS: A valid VD sample, as measured by serum 25-hydroxyvitamin D 
      (25-OHD), was obtained from nine consecutive psycogeriatric inpatients (66%
      women), during a one-month period in 2011. The Research Ethics Boards at St.
      Joseph's Healthcare Hamilton approved this project. RESULTS: All participants
      showed VD inadequacy (defined as 25-OHD </= 75 nmol/L) with a mean level of serum
      25-OHD of 45.5 +/- 14.6 (range 28.5-73.4) nmol/L. None of the patients in the
      sample met criteria for VD deficiency (currently defined by expert consensus as
      25-OHD < 25 nmol/L). Mean serum VD levels were lower in females (38.8 +/- 9.8
      nmol/L) than in males (59.0 +/- 14.3 nmol/L), p = .03. Magnesium and PTH were
      both higher in females (p = .03 and .02, respectively). Univariate linear
      regression analysis showed that VD levels were strongly negatively associated
      with magnesium (p = .001) and PTH (p = .02). CONCLUSION: Since research links VD 
      deficiency to psychiatric conditions, high rates of insufficiency in this
      population is very common and routine supplements are strongly suggested,
      regardless of patients' living environment.
FAU - Ford, Jennifer
AU  - Ford J
AD  - Department of Psychiatry and Behavioural Neurosciences, Michael G. DeGroote
      School of Medicine, Faculty of Health Sciences, McMaster University, Hamilton,
      ON;
FAU - Hategan, Ana
AU  - Hategan A
FAU - Bourgeois, James A
AU  - Bourgeois JA
FAU - Tisi, Daniel K
AU  - Tisi DK
LA  - eng
PT  - Journal Article
DEP - 20120920
PL  - Canada
TA  - Can Geriatr J
JT  - Canadian geriatrics journal : CGJ
JID - 101579189
PMC - PMC3521320
OTO - NOTNLM
OT  - acute inpatient
OT  - geriatric
OT  - psychiatric disorders
OT  - vitamin D
OT  - vitamin D insufficiency
EDAT- 2012/12/22 06:00
MHDA- 2012/12/22 06:01
CRDT- 2012/12/22 06:00
PHST- 2012/12/22 06:00 [entrez]
PHST- 2012/12/22 06:00 [pubmed]
PHST- 2012/12/22 06:01 [medline]
AID - 10.5770/cgj.15.39 [doi]
AID - cgj-15-80 [pii]
PST - ppublish
SO  - Can Geriatr J. 2012 Sep;15(3):80-4. doi: 10.5770/cgj.15.39. Epub 2012 Sep 20.


PMID- 23259011
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121224
LR  - 20211021
IS  - 1925-8348 (Print)
IS  - 1925-8348 (Linking)
VI  - 15
IP  - 1
DP  - 2012 Mar
TI  - A quality assurance study to assess the one-day prevalence of delirium in elderly
      hospitalized patients.
PG  - 2-7
LID - 10.5770/cgj.15.15 [doi]
AB  - BACKGROUND: Research indicates that 40% of hospital-acquired delirium cases may
      be preventable. However, despite its clinical significance, delirium often goes
      unrecognized or is misdiagnosed. The purpose of this study was to assess the need
      for delirium education in acute care hospitals in Hamilton, Ontario. METHODS:
      Approximately 100 health professionals were trained as delirium screeners. On
      'Delirium Day', all patients >/= 65 years of age in non-critical care areas in
      all acute care sites in Hamilton were identified. Those willing to take part in
      the prevalence study were assessed for delirium using the Standardized
      Mini-Mental State Examination and the Confusion Assessment Method. The Research
      Ethics Boards at Hamilton Health Sciences and St. Joseph's Healthcare Hamilton
      approved this quality assurance project. RESULTS: Of the 562 patients eligible
      for screening, eight were excluded and six did not have sufficient data collected
      to assess for delirium. Of the 548 individuals screened for delirium, 10.6%
      screened positive. Prevalence estimates ranged by site from 0% to 21% and type of
      unit from 3.8% to 16%. Recognition of delirium by nursing staff was fair; but,
      documentation was usually absent. CONCLUSION: While the prevalence rates were
      somewhat lower than in other studies, the results support the need for education 
      among health-care providers in the prevention, identification, and management of 
      delirium.
FAU - McAiney, Carrie A
AU  - McAiney CA
AD  - Department of Psychiatry and Behavioural Neurosciences, McMaster University,
      Hamilton, Ontario ; St. Joseph's Healthcare Hamilton, Hamilton, Ontario.
FAU - Patterson, Christopher
AU  - Patterson C
FAU - Coker, Esther
AU  - Coker E
FAU - Pizzacalla, Anne
AU  - Pizzacalla A
LA  - eng
PT  - Journal Article
DEP - 20120314
PL  - Canada
TA  - Can Geriatr J
JT  - Canadian geriatrics journal : CGJ
JID - 101579189
PMC - PMC3516239
OTO - NOTNLM
OT  - acute care
OT  - delirium
OT  - education
OT  - elderly
OT  - healthcare providers
EDAT- 2012/12/22 06:00
MHDA- 2012/12/22 06:01
CRDT- 2012/12/22 06:00
PHST- 2012/12/22 06:00 [entrez]
PHST- 2012/12/22 06:00 [pubmed]
PHST- 2012/12/22 06:01 [medline]
AID - 10.5770/cgj.15.15 [doi]
AID - cgj-15-2 [pii]
PST - ppublish
SO  - Can Geriatr J. 2012 Mar;15(1):2-7. doi: 10.5770/cgj.15.15. Epub 2012 Mar 14.


PMID- 23258724
OWN - NLM
STAT- MEDLINE
DCOM- 20131216
LR  - 20191210
IS  - 1518-8345 (Electronic)
IS  - 0104-1169 (Linking)
VI  - 20
IP  - 6
DP  - 2012 Nov-Dec
TI  - Nursing Intervention Classifications (NIC) validated for patients at risk of
      pressure ulcers.
PG  - 1109-16
LID - S0104-11692012000600013 [pii]
AB  - OBJECTIVE: to validate the Nursing Intervention Classifications (NIC) for the
      diagnosis 'Risk of Impaired Skin Integrity' in patients at risk of pressure
      ulcers (PU). METHOD: the sample comprised 16 expert nurses. The data was
      collected with an instrument about the interventions and their definitions were
      scored on a Likert scale by the experts. The data was analyzed statistically,
      using the calculation of weighted averages (WA). The study was approved by the
      Research Ethics Committee (56/2010). RESULTS: nine interventions were validated
      as 'priority' (WA >/=0.80), among them Prevention of PU (MP=0.92); 22 as
      'suggested' (WA >0.50 and <0.80) and 20 were discarded (WA </=0.50). CONCLUSIONS:
      the prevention of PU results from the implementation of specific interventions
      related to the risk factors for development of the lesion, with implications for 
      nursing practice, teaching and research.
FAU - Bavaresco, Taline
AU  - Bavaresco T
AD  - Universidade de Caxias do Sul, Brazil. tali_nurse@yahoo.com.br
FAU - Lucena, Amalia de Fatima
AU  - Lucena Ade F
LA  - eng
LA  - por
LA  - spa
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
PL  - Brazil
TA  - Rev Lat Am Enfermagem
JT  - Revista latino-americana de enfermagem
JID - 9420934
MH  - Humans
MH  - Nursing Process/*classification
MH  - Pressure Ulcer/*nursing
MH  - Risk Factors
MH  - Vocabulary, Controlled
EDAT- 2012/12/22 06:00
MHDA- 2013/12/18 06:00
CRDT- 2012/12/22 06:00
PHST- 2012/08/27 00:00 [received]
PHST- 2012/10/31 00:00 [accepted]
PHST- 2012/12/22 06:00 [entrez]
PHST- 2012/12/22 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
AID - S0104-11692012000600013 [pii]
AID - 10.1590/s0104-11692012000600013 [doi]
PST - ppublish
SO  - Rev Lat Am Enfermagem. 2012 Nov-Dec;20(6):1109-16. doi:
      10.1590/s0104-11692012000600013.


PMID- 23258720
OWN - NLM
STAT- MEDLINE
DCOM- 20131216
LR  - 20190608
IS  - 1518-8345 (Electronic)
IS  - 0104-1169 (Linking)
VI  - 20
IP  - 6
DP  - 2012 Nov-Dec
TI  - Predisposing factors for peripheral intravenous puncture failure in children.
PG  - 1072-80
LID - S0104-11692012000600009 [pii]
AB  - OBJECTIVE: To identify predisposing factors for peripheral intravenous puncture
      failure in children. METHODS: Cross-sectional cohort study conducted with 335
      children in a pediatric ward of a university hospital after approval of the
      ethics committee. The Wald Chi-squared, Prevalence Ratio (PR) and backward
      procedure (p</=0.05) tests were applied. RESULTS: Success of peripheral
      intravenous puncture was obtained in 300 (89.5%) children and failure in 35
      (10.4%). The failure rates were significantly influenced by: presence of clinical
      history of difficult venous access, malnourishment, previous use of peripherally 
      inserted central venous catheter, previous use of central venous catheter, and
      history of phlebitis or infiltration. In the multivariate model, being
      malnourished and having previously been submitted to central venous
      catheterization were the predisposing factors for the failure. CONCLUSION: The
      failure rate of 10.4% is similar to that identified in analogous studies and was 
      influenced by characteristics of the children and intravenous therapy. In
      association with this, malnutrition and previous use of a central venous catheter
      were the most important variables influencing increase in peripheral intravenous 
      puncture failure.
FAU - de Negri, Daniela Cavalcante
AU  - de Negri DC
AD  - Universidade Federal de Sao Paulo, Brazil.
FAU - Avelar, Ariane Ferreira Machado
AU  - Avelar AF
FAU - Andreoni, Solange
AU  - Andreoni S
FAU - Pedreira, Mavilde da Luz Goncalvez
AU  - Pedreira Mda L
LA  - eng
LA  - por
LA  - spa
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Brazil
TA  - Rev Lat Am Enfermagem
JT  - Revista latino-americana de enfermagem
JID - 9420934
MH  - Adolescent
MH  - Catheterization, Peripheral/*methods
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - *Punctures
MH  - Treatment Failure
EDAT- 2012/12/22 06:00
MHDA- 2013/12/18 06:00
CRDT- 2012/12/22 06:00
PHST- 2012/01/26 00:00 [received]
PHST- 2012/10/10 00:00 [accepted]
PHST- 2012/12/22 06:00 [entrez]
PHST- 2012/12/22 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
AID - S0104-11692012000600009 [pii]
AID - 10.1590/s0104-11692012000600009 [doi]
PST - ppublish
SO  - Rev Lat Am Enfermagem. 2012 Nov-Dec;20(6):1072-80. doi:
      10.1590/s0104-11692012000600009.


PMID- 23258686
OWN - NLM
STAT- MEDLINE
DCOM- 20131216
LR  - 20190911
IS  - 1984-0446 (Electronic)
IS  - 0034-7167 (Linking)
VI  - 65
IP  - 4
DP  - 2012 Jul-Aug
TI  - [Ethics training of nurses: what is the Portuguese reality?].
PG  - 653-9
LID - S0034-71672012000400015 [pii]
AB  - Recognizing the existence of education policies that guide the teaching of Ethics
      in Nursing, our aim was to know the reality of the initial training of nurses in 
      Portugal. The conceptual framework was accomplished in the consultation and the
      complete documents' readings (especially the recommendations of the Portuguese
      Order of Nurses), crossed with foundational conceptions of Nursing Ethics and
      Philosophy authors, in particular Watson and Mounier. Some of the conclusions of 
      this study relate to the verification that only five establishments comply with
      the Order of Nurses recommendations regarding the teaching of Ethics and
      Deontology. There is also a variability of classifications assigned to
      subjects/courses and program content/curriculum, embedded in them; there is a
      large discrepancy in the workload assigned to different curriculum areas.
FAU - Reis, Ana Maria
AU  - Reis AM
AD  - Cooperativa de Ensino Superior, Politecnico e Universitario, Escola Superior de
      Saude do Vale do Ave. Vila Nova de Famalicao, Portugal. ana.greis@sapo.pt
FAU - Oliveira, Clara Costa
AU  - Oliveira CC
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Formacao etica dos enfermeiros: qual a realidade Portuguesa?
PL  - Brazil
TA  - Rev Bras Enferm
JT  - Revista brasileira de enfermagem
JID - 7910105
MH  - Curriculum
MH  - Ethics, Nursing/*education
MH  - Portugal
EDAT- 2012/12/22 06:00
MHDA- 2013/12/18 06:00
CRDT- 2012/12/22 06:00
PHST- 2012/02/19 00:00 [received]
PHST- 2012/10/08 00:00 [accepted]
PHST- 2012/12/22 06:00 [entrez]
PHST- 2012/12/22 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
AID - S0034-71672012000400015 [pii]
AID - 10.1590/s0034-71672012000400015 [doi]
PST - ppublish
SO  - Rev Bras Enferm. 2012 Jul-Aug;65(4):653-9. doi: 10.1590/s0034-71672012000400015.


PMID- 23258082
OWN - NLM
STAT- MEDLINE
DCOM- 20141010
LR  - 20211021
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 40
IP  - 2
DP  - 2014 Feb
TI  - How can bedside rationing be justified despite coexisting inefficiency? The need 
      for 'benchmarks of efficiency'.
PG  - 89-93
LID - 10.1136/medethics-2012-100769 [doi]
AB  - Imperfect efficiency in healthcare delivery is sometimes given as a justification
      for refusing to ration or even discuss how to pursue fair rationing. This paper
      aims to clarify the relationship between inefficiency and rationing, and the
      conditions under which bedside rationing can be justified despite coexisting
      inefficiency. This paper first clarifies several assumptions that underlie the
      classification of a clinical practice as being inefficient. We then suggest that 
      rationing is difficult to justify in circumstances where the rationing agent is
      or should be aware of and contributes to clinical inefficiency. We further
      explain the different ethical implications of this suggestion for rationing
      decisions made by clinicians. We argue that rationing is more legitimate when
      sufficient efforts are undertaken to decrease inefficiency in parallel with
      efforts to pursue unavoidable but fair rationing. While the qualifier
      'sufficient' is crucial here, we explain why 'sufficient efforts' should be
      translated into 'benchmarks of efficiency' that address specific healthcare
      activities where clinical inefficiency can be decreased. Referring to recent
      consensus papers, we consider some examples of specific clinical situations where
      improving clinical inefficiency has been recommended and consider how benchmarks 
      for efficiency might apply. These benchmarks should state explicitly how much
      inefficiency shall be reduced in a reasonable time range and why these efforts
      are 'sufficient'. Possible strategies for adherence to benchmarks are offered to 
      address the possibility of non-compliance.
FAU - Strech, Daniel
AU  - Strech D
AD  - Institute for History, Ethics and Philosophy in Medicine, Hannover Medical
      School, , Hannover, Germany.
FAU - Danis, Marion
AU  - Danis M
LA  - eng
GR  - Z99 CL999999/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
DEP - 20121220
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
CIN - J Med Ethics. 2014 Feb;40(2):94-6. PMID: 24293636
MH  - Benchmarking/economics/*ethics
MH  - Delivery of Health Care/economics/*ethics
MH  - Efficiency, Organizational/economics/*ethics/standards
MH  - Germany
MH  - Health Care Rationing/*economics/*ethics
MH  - Health Services Needs and Demand/economics/ethics
MH  - Humans
MH  - Patient Selection/*ethics
MH  - Social Responsibility
PMC - PMC4849544
MID - NIHMS772563
OTO - NOTNLM
OT  - Allocation of Health Care Resources
EDAT- 2012/12/22 06:00
MHDA- 2014/10/11 06:00
CRDT- 2012/12/22 06:00
PHST- 2012/12/22 06:00 [entrez]
PHST- 2012/12/22 06:00 [pubmed]
PHST- 2014/10/11 06:00 [medline]
AID - medethics-2012-100769 [pii]
AID - 10.1136/medethics-2012-100769 [doi]
PST - ppublish
SO  - J Med Ethics. 2014 Feb;40(2):89-93. doi: 10.1136/medethics-2012-100769. Epub 2012
      Dec 20.


PMID- 23257990
OWN - NLM
STAT- MEDLINE
DCOM- 20130509
LR  - 20220318
IS  - 1471-6771 (Electronic)
IS  - 0007-0912 (Linking)
VI  - 110
IP  - 4
DP  - 2013 Apr
TI  - Proportion of surgical patients with undiagnosed obstructive sleep apnoea.
PG  - 629-36
LID - 10.1093/bja/aes465 [doi]
AB  - BACKGROUND: Obstructive sleep apnoea (OSA) affects ~9-24% of the general
      population, and 90% remain undiagnosed. Those patients with undiagnosed
      moderate-to-severe OSA may be associated with an increased risk of perioperative 
      complications. Our objective was to evaluate the proportion of surgical patients 
      with undiagnosed moderate-to-severe OSA. METHODS: After research ethics board
      approval, patients visiting preoperative clinics were recruited over 4 yr and
      screened with the STOP-BANG questionnaire. The 1085 patients, who consented,
      subsequently underwent polysomnography (PSG) (laboratory or portable) before
      operation. Chart review was conducted in this historical cohort to ascertain the 
      clinical diagnosis of OSA by surgeons and anaesthetists, blinded to the PSG
      results. The PSG study-identified OSA patients were further classified based on
      severity using the apnoea-hypopnoea index (AHI) cut-offs. RESULTS: Of 819
      patients, 111 patients had pre-existing OSA and 58% (64/111) were not diagnosed
      by the surgeons and 15% (17/111) were not diagnosed by the anaesthetists. Among
      the 708 study patients, PSG showed that 233 (31%) had no OSA, 218 (31%) patients 
      had mild OSA (AHI: 5-15); 148 (21%) had moderate OSA (AHI: 15-30), and 119 (17%) 
      had severe OSA (AHI>30). Before operation, of the 267 patients with
      moderate-to-severe OSA, 92% (n=245) and 60% (n=159) were not diagnosed by the
      surgeons and the anaesthetists, respectively. CONCLUSIONS: We found that
      anaesthetists and surgeons failed to identify a significant number of patients
      with pre-existing OSA and symptomatic undiagnosed OSA, before operation. This
      study may provide an impetus for more diligent case finding of OSA before
      operation.
FAU - Singh, M
AU  - Singh M
AD  - Department of Anaesthesia, University Health Network, University of Totonto,
      Toronto, Canada.
FAU - Liao, P
AU  - Liao P
FAU - Kobah, S
AU  - Kobah S
FAU - Wijeysundera, D N
AU  - Wijeysundera DN
FAU - Shapiro, C
AU  - Shapiro C
FAU - Chung, F
AU  - Chung F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121219
PL  - England
TA  - Br J Anaesth
JT  - British journal of anaesthesia
JID - 0372541
SB  - IM
MH  - Aged
MH  - Cohort Studies
MH  - Continuous Positive Airway Pressure
MH  - Electroencephalography
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Patients
MH  - Physicians
MH  - Polysomnography
MH  - Preoperative Care
MH  - Sample Size
MH  - Sleep Apnea, Obstructive/*diagnosis/*epidemiology
MH  - Surgical Procedures, Operative
EDAT- 2012/12/22 06:00
MHDA- 2013/05/10 06:00
CRDT- 2012/12/22 06:00
PHST- 2012/12/22 06:00 [entrez]
PHST- 2012/12/22 06:00 [pubmed]
PHST- 2013/05/10 06:00 [medline]
AID - S0007-0912(17)32732-0 [pii]
AID - 10.1093/bja/aes465 [doi]
PST - ppublish
SO  - Br J Anaesth. 2013 Apr;110(4):629-36. doi: 10.1093/bja/aes465. Epub 2012 Dec 19.


PMID- 23257969
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20211021
IS  - 1758-1095 (Electronic)
IS  - 0141-0768 (Linking)
VI  - 105
IP  - 11
DP  - 2012 Nov
TI  - The role of doctors in investigation, prevention and treatment of torture.
PG  - 464-71
LID - 10.1258/jrsm.2012.120100 [doi]
AB  - Doctors may assess and treat torture survivors; some may document crucial
      evidence of torture in medico-legal reports. However, there is a lack of
      education on torture and related ethical and legal issues at undergraduate and
      postgraduate level and many doctors are not aware of opportunities to work with
      organisations for the prevention of torture. This paper defines Torture,
      describes methods used, and sets out the human rights instruments and codes of
      ethical practice that mandate efforts to prevent torture. Medical complicity in
      torture is discussed and the need for national and international medical
      associations to prevent torture by both supporting doctors and recognising and
      tackling medial complicity. The paper offers guidance for assessing and
      documenting torture, and for providing health care for survivors of torture.
FAU - McColl, Helen
AU  - McColl H
AD  - Liaison Psychiatry, Sussex Partnership Foundation Trust, Hove BN3 1AS, UK.
FAU - Bhui, Kamaldeep
AU  - Bhui K
FAU - Jones, Edgar
AU  - Jones E
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J R Soc Med
JT  - Journal of the Royal Society of Medicine
JID - 7802879
SB  - IM
MH  - *Codes of Ethics
MH  - Complicity
MH  - Crime/prevention & control
MH  - Crime Victims
MH  - Delivery of Health Care/*ethics
MH  - *Ethics, Medical
MH  - *Human Rights
MH  - Humans
MH  - *Physician's Role
MH  - Physicians/*ethics
MH  - Survivors
MH  - Torture/*ethics/legislation & jurisprudence
PMC - PMC3526851
EDAT- 2012/12/22 06:00
MHDA- 2013/02/13 06:00
CRDT- 2012/12/22 06:00
PHST- 2012/12/22 06:00 [entrez]
PHST- 2012/12/22 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
AID - 105/11/464 [pii]
AID - 10.1258/JRSM.2012.120100 [doi]
PST - ppublish
SO  - J R Soc Med. 2012 Nov;105(11):464-71. doi: 10.1258/JRSM.2012.120100.


PMID- 23257888
OWN - NLM
STAT- MEDLINE
DCOM- 20130930
LR  - 20220409
IS  - 1423-0151 (Electronic)
IS  - 1011-7571 (Linking)
VI  - 22
IP  - 3
DP  - 2013
TI  - Thoracic paravertebral block for postoperative pain management in percutaneous
      nephrolithotomy patients: a randomized controlled clinical trial.
PG  - 229-33
LID - 10.1159/000345381 [doi]
AB  - OBJECTIVE: To investigate the effect of thoracic paravertebral block (PVB) on
      pain control and morphine consumption in percutaneous nephrolithotomy operations.
      SUBJECTS AND METHODS: This randomized controlled clinical study was performed on 
      60 American Society of Anesthesiologists (ASA) I-II patients between the ages of 
      18 and 60 years who underwent percutaneous nephrolithotomy with approval of the
      ethical committee and written consent of the patients. Patients were randomly
      allocated into two groups: group P had 4 ml of 0.5% levobupivacaine injected at
      each of the T10, T11, and T12 paravertebral spaces and a standard PVB, and group 
      C received 4 ml of 0.9% NaCl solution. All patients were given standard general
      anesthesia. The follow-up of saturation, heart rate, peripheral oxygen, and blood
      pressure values was recorded before induction, intraoperatively, and
      postoperatively. At postoperative 1, 2, 6, 12, and 24 h, the visual analog scale 
      (VAS), Ramsey sedation score, respiratory rate, and 24-hour total morphine
      consumption were recorded. In addition, side effects and satisfaction of patients
      were recorded. RESULTS: VAS scores and total morphine consumption were lower in
      group P than in group C: 2.3 vs. 4.3 and 22.3 vs. 43.2 mg, respectively (p <
      0.05). The level of satisfaction was higher in group P than group C. Differences 
      between groups in other parameters were not significant. CONCLUSIONS: Thoracic
      PVB with levobupivacaine provided a good postoperative analgesia and increased
      patient satisfaction for those who underwent percutaneous nephrolithotomy.
CI  - Copyright (c) 2012 S. Karger AG, Basel.
FAU - Ak, K
AU  - Ak K
AD  - Department of Anesthesiology, Cumhuriyet University, School of Medicine, Sivas,
      Turkey.
FAU - Gursoy, S
AU  - Gursoy S
FAU - Duger, C
AU  - Duger C
FAU - Isbir, A C
AU  - Isbir AC
FAU - Kaygusuz, K
AU  - Kaygusuz K
FAU - Ozdemir Kol, I
AU  - Ozdemir Kol I
FAU - Gokce, G
AU  - Gokce G
FAU - Mimaroglu, C
AU  - Mimaroglu C
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20121214
PL  - Switzerland
TA  - Med Princ Pract
JT  - Medical principles and practice : international journal of the Kuwait University,
      Health Science Centre
JID - 8901334
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Anesthetics, Local)
RN  - 76I7G6D29C (Morphine)
RN  - A5H73K9U3W (Levobupivacaine)
RN  - Y8335394RO (Bupivacaine)
SB  - IM
MH  - Adult
MH  - Analgesics, Opioid/administration & dosage
MH  - Anesthetics, Local/administration & dosage/*therapeutic use
MH  - Bupivacaine/administration & dosage/analogs & derivatives/therapeutic use
MH  - Female
MH  - Humans
MH  - Injections, Spinal
MH  - Levobupivacaine
MH  - Male
MH  - Middle Aged
MH  - Morphine/administration & dosage
MH  - *Nephrostomy, Percutaneous
MH  - Pain Management/*methods
MH  - Pain Measurement
MH  - Pain, Postoperative/*drug therapy
MH  - Thoracic Vertebrae
MH  - Time Factors
PMC - PMC5586743
EDAT- 2012/12/22 06:00
MHDA- 2013/10/01 06:00
CRDT- 2012/12/22 06:00
PHST- 2012/10/06 00:00 [received]
PHST- 2012/10/23 00:00 [accepted]
PHST- 2012/12/22 06:00 [entrez]
PHST- 2012/12/22 06:00 [pubmed]
PHST- 2013/10/01 06:00 [medline]
AID - 000345381 [pii]
AID - 10.1159/000345381 [doi]
PST - ppublish
SO  - Med Princ Pract. 2013;22(3):229-33. doi: 10.1159/000345381. Epub 2012 Dec 14.


PMID- 23257808
OWN - NLM
STAT- MEDLINE
DCOM- 20131129
LR  - 20151119
IS  - 1476-5373 (Electronic)
IS  - 0007-0610 (Linking)
VI  - 213
IP  - 12
DP  - 2012 Dec
TI  - Influence of immediate post-extraction socket irrigation on development of
      alveolar osteitis after mandibular third molar removal: a prospective split-mouth
      study, preliminary report.
PG  - 597-601
LID - 10.1038/sj.bdj.2012.1134 [doi]
AB  - PURPOSE: The aim of this prospective comparative split-mouth study was to
      evaluate the role of socket irrigation with a normal saline solution routinely
      used at the end of extraction on the development of alveolar osteitis (AO) after 
      removal of impacted mandibular third molars (MTMs). MATERIALS AND METHODS:
      Thirty-five patients who satisfied the inclusion criteria were involved in the
      study and underwent extraction of four third-molars. To be included in the study,
      the mandibular third molars had to be impacted (partial or full bone) and require
      an osteotomy for extraction with use of a motorised drill. All surgeries were
      done under local anaesthesia or IV sedation. This was a prospective split-mouth
      study. The patient's left (assistant) side was a control side; it had a standard 
      extraction technique of an impacted mandibular third molar that required a buccal
      full-thickness flap, buccal trough (osteotomy) and extraction of the tooth (with 
      or without splitting the tooth into segments), followed by a traditional
      end-of-surgery debridement protocol consisting of a gentle curettage, bone filing
      of the socket walls, socket irrigation with approximately 5 ml of sterile normal 
      saline solution and socket suctioning. The patient's right (operator) side was an
      experimental side; it also had a standard extraction technique of an impacted
      mandibular third molar at the beginning with a flap and osteotomy, but it was
      followed by a modified end-of-surgery protocol. It consisted of gentle curettage 
      but the socket was not irrigated and not suctioned. It was simply left to bleed. 
      The gauze was placed on top of the socket for haemostasis on both sides and the
      patient was asked to bite. On both sides, the buccal flap was positioned back
      without the suture. All patients were seen for a follow-up appointment four to
      seven days after the surgery to assess healing and check for symptoms and signs
      of alveolar osteitis, if present, on both irrigated and non-irrigated sides. This
      study followed the ethical guidelines of human subjects based on the Helsinki
      Declaration. RESULTS: Thirty-five patients or 70 sockets were evaluated. Eleven
      out of 35 patients in the study were subjected to a dry socket syndrome (31.4%). 
      The higher number of AO was likely related to specifics of MTM selection in this 
      study - only impacted (partial and full bone) MTMs were chosen. Among eleven
      patients with AO, two patients had a bilateral condition. By excluding two
      patients with bilateral dry sockets from the study, there were nine patients (18 
      extraction sites) with unilateral AO in the study. Seven out of nine patients (14
      extraction sites) developed unilateral dry socket on the control (irrigated) side
      (77.8%) and only two (four extraction sites) on the experimental (non-irrigated) 
      side (22.2%). Therefore, in this study there were 3.5 times more patients
      (extraction sites) with dry socket syndrome on the irrigated (control) side than 
      patients (extraction sites) in the non-irrigated (experimental) side. CONCLUSION:
      A noticeable difference of dry socket syndromes (77.8% on the irrigated versus
      22.2% on non-irrigated side) was demonstrated between the traditional extraction 
      protocol versus modified approach without the end-of-surgery irrigation. The
      study demonstrated that the post-extraction socket bleeding is very important for
      the proper uncomplicated socket healing. If it's not washed away with irrigation 
      solution at the end of extraction, the normal blood clot has a higher likelihood 
      to form, and therefore, can potentially lead to an uncomplicated socket healing
      without development of alveolar osteitis. Socket bleeding at the extraction site 
      creates a favourable environment for the formation of a blood clot - a protective
      dressing - necessary for a favourable osseous healing of the socket.
FAU - Tolstunov, L
AU  - Tolstunov L
AD  - Van Ness Oral Surgery and Implantology Center, 1 Daniel Burnham Court, Suite
      366C, San Francisco, CA 94109, USA. tolstunov@yahoo.com
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Br Dent J
JT  - British dental journal
JID - 7513219
RN  - 451W47IQ8X (Sodium Chloride)
SB  - IM
CIN - Br Dent J. 2013 May;214(10):485. PMID: 23703163
MH  - Adolescent
MH  - Adult
MH  - Dry Socket/*etiology/prevention & control
MH  - Female
MH  - Humans
MH  - Male
MH  - Mandible/surgery
MH  - Molar, Third/*surgery
MH  - Prospective Studies
MH  - Sodium Chloride/adverse effects/*therapeutic use
MH  - Therapeutic Irrigation/*methods
MH  - Tooth Extraction/*adverse effects/methods
MH  - Tooth Socket/*pathology
MH  - Tooth, Impacted/*complications/surgery
MH  - Wound Healing/physiology
EDAT- 2012/12/22 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/12/22 06:00
PHST- 2012/05/25 00:00 [accepted]
PHST- 2012/12/22 06:00 [entrez]
PHST- 2012/12/22 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - sj.bdj.2012.1134 [pii]
AID - 10.1038/sj.bdj.2012.1134 [doi]
PST - ppublish
SO  - Br Dent J. 2012 Dec;213(12):597-601. doi: 10.1038/sj.bdj.2012.1134.


PMID- 23257774
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121224
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 6
DP  - 2012
TI  - Evaluating the impact and use of Transparent Reporting of Evaluations with
      Non-randomised Designs (TREND) reporting guidelines.
LID - 10.1136/bmjopen-2012-002073 [doi]
LID - e002073 [pii]
AB  - INTRODUCTION: Accurate and full reporting of evaluation of interventions in
      health research is needed for evidence synthesis and informed decision-making.
      Evidence suggests that biases and incomplete reporting affect the assessment of
      study validity and the ability to include this data in secondary research. The
      Transparent Reporting of Evaluations with Non-randomised Designs (TREND)
      reporting guideline was developed to improve the transparency and accuracy of the
      reporting of behavioural and public health evaluations with non-randomised
      designs. Evaluations of reporting guidelines have shown that they can be
      effective in improving reporting completeness. Although TREND occupies a niche
      within reporting guidelines, and despite it being 8 years since publication, no
      study yet has assessed its impact on reporting completeness or investigated what 
      factors affect its use by authors and journal editors. This protocol describes
      two studies that aim to redress this. METHODS AND ANALYSIS: Study 1 will use an
      observational design to examine the uptake and use of TREND by authors, and by
      journals in their instructions to authors. A comparison of reporting completeness
      and study quality of papers that do and do not use TREND to inform reporting will
      be made. Study 2 will use a cross-sectional survey to investigate what factors
      inhibit or facilitate authors' and journal editors' use of TREND. Semistructured 
      interviews will also be conducted with a subset of authors and editors to explore
      findings from study 1 and the surveys in greater depth. ETHICS AND DISSEMINATION:
      These studies will generate evidence of how implementation and dissemination of
      the TREND guideline has affected reporting completeness in studies with
      experimental, non-randomised designs within behavioural and public health
      research. The project has received ethics approval from the Research Ethics
      Committee of the Peninsula College of Medicine and Dentistry, Universities of
      Exeter and Plymouth.
FAU - Fuller, Thomas
AU  - Fuller T
AD  - Peninsula Collaborations for Leadership in Applied Health Research and Care
      (PenCLAHRC), University of Exeter, Exeter, UK.
FAU - Pearson, Mark
AU  - Pearson M
FAU - Peters, Jaime L
AU  - Peters JL
FAU - Anderson, Rob
AU  - Anderson R
LA  - eng
PT  - Journal Article
DEP - 20121219
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3533093
EDAT- 2012/12/22 06:00
MHDA- 2012/12/22 06:01
CRDT- 2012/12/22 06:00
PHST- 2012/12/22 06:00 [entrez]
PHST- 2012/12/22 06:00 [pubmed]
PHST- 2012/12/22 06:01 [medline]
AID - bmjopen-2012-002073 [pii]
AID - 10.1136/bmjopen-2012-002073 [doi]
PST - epublish
SO  - BMJ Open. 2012 Dec 19;2(6). pii: bmjopen-2012-002073. doi:
      10.1136/bmjopen-2012-002073. Print 2012.


PMID- 23257690
OWN - NLM
STAT- MEDLINE
DCOM- 20130528
LR  - 20220410
IS  - 1423-0356 (Electronic)
IS  - 0025-7931 (Linking)
VI  - 85
IP  - 1
DP  - 2013
TI  - Introduction to stem cells and regenerative medicine.
PG  - 3-10
LID - 10.1159/000345615 [doi]
AB  - Stem cells are a population of undifferentiated cells characterized by the
      ability to extensively proliferate (self-renewal), usually arise from a single
      cell (clonal), and differentiate into different types of cells and tissue
      (potent). There are several sources of stem cells with varying potencies.
      Pluripotent cells are embryonic stem cells derived from the inner cell mass of
      the embryo and induced pluripotent cells are formed following reprogramming of
      somatic cells. Pluripotent cells can differentiate into tissue from all 3 germ
      layers (endoderm, mesoderm, and ectoderm). Multipotent stem cells may
      differentiate into tissue derived from a single germ layer such as mesenchymal
      stem cells which form adipose tissue, bone, and cartilage. Tissue-resident stem
      cells are oligopotent since they can form terminally differentiated cells of a
      specific tissue. Stem cells can be used in cellular therapy to replace damaged
      cells or to regenerate organs. In addition, stem cells have expanded our
      understanding of development as well as the pathogenesis of disease.
      Disease-specific cell lines can also be propagated and used in drug development. 
      Despite the significant advances in stem cell biology, issues such as ethical
      controversies with embryonic stem cells, tumor formation, and rejection limit
      their utility. However, many of these limitations are being bypassed and this
      could lead to major advances in the management of disease. This review is an
      introduction to the world of stem cells and discusses their definition, origin,
      and classification, as well as applications of these cells in regenerative
      medicine.
CI  - Copyright (c) 2012 S. Karger AG, Basel.
FAU - Kolios, George
AU  - Kolios G
AD  - Laboratory of Pharmacology, Faculty of Medicine, Democritus University of Thrace,
      Alexandroupolis, Greece. gkolios@med.duth.gr
FAU - Moodley, Yuben
AU  - Moodley Y
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121213
PL  - Switzerland
TA  - Respiration
JT  - Respiration; international review of thoracic diseases
JID - 0137356
SB  - IM
MH  - Humans
MH  - Lung Diseases/*surgery
MH  - Regenerative Medicine/*methods
MH  - Stem Cell Transplantation/*methods
MH  - Stem Cells/*classification/cytology
EDAT- 2012/12/22 06:00
MHDA- 2013/05/29 06:00
CRDT- 2012/12/22 06:00
PHST- 2012/12/22 06:00 [entrez]
PHST- 2012/12/22 06:00 [pubmed]
PHST- 2013/05/29 06:00 [medline]
AID - 000345615 [pii]
AID - 10.1159/000345615 [doi]
PST - ppublish
SO  - Respiration. 2013;85(1):3-10. doi: 10.1159/000345615. Epub 2012 Dec 13.


PMID- 23257394
OWN - NLM
STAT- MEDLINE
DCOM- 20130823
LR  - 20220317
IS  - 1460-2350 (Electronic)
IS  - 0268-1161 (Linking)
VI  - 28
IP  - 3
DP  - 2013 Mar
TI  - Human trophectoderm cells are not yet committed.
PG  - 740-9
LID - 10.1093/humrep/des432 [doi]
AB  - STUDY QUESTION: Are human trophectoderm (TE) cells committed or still able to
      develop into inner cell mass (ICM) cells? SUMMARY ANSWER: Human full blastocyst
      TE cells still have the capacity to develop into ICM cells expressing the
      pluripotency marker NANOG, thus they are not yet committed. WHAT IS KNOWN
      ALREADY: Human Day 5 full blastocyst TE cells express the pluripotency markers
      POU5F1, SOX2 and SALL4 as well as the TE markers HLA-G and KRT18 but not yet
      CDX2, therefore their developmental direction may not yet be definite. STUDY
      DESIGN, SIZE, DURATION: The potency of human blastocyst TE cells was investigated
      by determining their in vitro capacity to develop into a blastocyst with ICM
      cells expressing NANOG; TE cells were isolated either by aspiration under visual 
      control or after labeling with fluorescent 594-wheat germ agglutinin. Further on,
      aspirated TE cells were also labeled with fluorescent PKH67 and repositioned in
      the center of the original embryo. PARTICIPANTS/MATERIALS, SETTING, METHODS:
      Human preimplantation embryos were used for research after obtaining informed
      consent from IVF patients. The experiments were approved by the Local Ethical
      Committee and the 'Belgian Federal Committee on medical and scientific research
      on embryos in vitro'. Outer cells were isolated and reaggregated by
      micromanipulation. Reconstituted embryos were analyzed by immunocytochemistry.
      MAIN RESULTS AND THE ROLE OF CHANCE: Isolated and reaggregated TE cells from full
      human blastocysts are able to develop into blastocysts with ICM cells expressing 
      the pluripotency marker NANOG. Moreover, the majority of the isolated TE cells
      which were repositioned in the center of the embryo do not sort back to their
      original position but integrate within the ICM and start to express NANOG.
      LIMITATIONS, REASONS FOR CAUTION: Owing to legal and ethical restrictions,
      manipulated human embryos cannot be transferred into the uterus to determine
      their totipotent capacity. The definitive demonstration that embryos
      reconstructed with TE cells are a source of pluripotent cells is to obtain human 
      embryonic stem cell 'like' line(s), which will allow full characterization of the
      cells. WIDER IMPLICATIONS OF THE FINDINGS: Our finding has important implications
      in reproductive medicine and stem cell biology because TE cells have a greater
      developmental potential than assumed previously. STUDY FUNDING/COMPETING
      INTEREST(S): Scientific Research Foundation-Flanders (FWO-Vlaanderen) and
      Research Council (OZR) of the Vrije Universiteit Brussel. None of the authors
      declared a conflict of interest.
FAU - De Paepe, Caroline
AU  - De Paepe C
AD  - Department of Reproduction and Genetics, Vrije Universiteit Brussel, Belgium.
FAU - Cauffman, Greet
AU  - Cauffman G
FAU - Verloes, An
AU  - Verloes A
FAU - Sterckx, Johan
AU  - Sterckx J
FAU - Devroey, Paul
AU  - Devroey P
FAU - Tournaye, Herman
AU  - Tournaye H
FAU - Liebaers, Inge
AU  - Liebaers I
FAU - Van de Velde, Hilde
AU  - Van de Velde H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121219
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
RN  - 0 (Fluorescent Dyes)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (NANOG protein, human)
RN  - 0 (Nanog Homeobox Protein)
RN  - 0 (Stage-Specific Embryonic Antigens)
SB  - IM
MH  - Blastocyst/*cytology/metabolism
MH  - Blastocyst Inner Cell Mass/cytology/metabolism
MH  - Cell Separation
MH  - *Ectogenesis
MH  - Embryo Culture Techniques
MH  - Embryonic Stem Cells/*cytology/metabolism
MH  - Fluorescent Dyes/chemistry
MH  - Homeodomain Proteins/metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Micromanipulation
MH  - Nanog Homeobox Protein
MH  - Pluripotent Stem Cells/*cytology/metabolism
MH  - Stage-Specific Embryonic Antigens/metabolism
MH  - Trophoblasts/cytology/metabolism
EDAT- 2012/12/22 06:00
MHDA- 2013/08/24 06:00
CRDT- 2012/12/22 06:00
PHST- 2012/12/22 06:00 [entrez]
PHST- 2012/12/22 06:00 [pubmed]
PHST- 2013/08/24 06:00 [medline]
AID - des432 [pii]
AID - 10.1093/humrep/des432 [doi]
PST - ppublish
SO  - Hum Reprod. 2013 Mar;28(3):740-9. doi: 10.1093/humrep/des432. Epub 2012 Dec 19.


PMID- 23257240
OWN - NLM
STAT- MEDLINE
DCOM- 20140108
LR  - 20181202
IS  - 1471-6348 (Electronic)
IS  - 0266-4623 (Linking)
VI  - 29
IP  - 1
DP  - 2013 Jan
TI  - An ethical evaluation of telemedicine applications must consider four major
      aspects - a comment on Kidholm et Al.
PG  - 110-1
LID - 10.1017/S0266462312000773 [doi]
FAU - Manzeschke, Arne
AU  - Manzeschke A
FAU - Weber, Karsten
AU  - Weber K
FAU - Fangerau, Heiner
AU  - Fangerau H
FAU - Rother, Elisabeth
AU  - Rother E
FAU - Quack, Friederike
AU  - Quack F
FAU - Dengler, Kathrin
AU  - Dengler K
LA  - eng
PT  - Letter
PT  - Comment
DEP - 20121221
PL  - England
TA  - Int J Technol Assess Health Care
JT  - International journal of technology assessment in health care
JID - 8508113
SB  - IM
CON - Int J Technol Assess Health Care. 2012 Jan;28(1):44-51. PMID: 22617736
MH  - Humans
MH  - *Models, Organizational
MH  - *Software
MH  - Technology Assessment, Biomedical/*methods
MH  - Telemedicine/*methods
EDAT- 2012/12/22 06:00
MHDA- 2014/01/09 06:00
CRDT- 2012/12/22 06:00
PHST- 2012/12/22 06:00 [entrez]
PHST- 2012/12/22 06:00 [pubmed]
PHST- 2014/01/09 06:00 [medline]
AID - S0266462312000773 [pii]
AID - 10.1017/S0266462312000773 [doi]
PST - ppublish
SO  - Int J Technol Assess Health Care. 2013 Jan;29(1):110-1. doi:
      10.1017/S0266462312000773. Epub 2012 Dec 21.


PMID- 23257119
OWN - NLM
STAT- MEDLINE
DCOM- 20131226
LR  - 20130222
IS  - 1471-8405 (Electronic)
IS  - 0962-7480 (Linking)
VI  - 63
IP  - 2
DP  - 2013 Mar
TI  - Blood and body fluid exposures: consent for source patient testing.
PG  - 135-7
LID - 10.1093/occmed/kqs210 [doi]
AB  - BACKGROUND: Exposure to blood and body fluids (BBF) remains a major occupational 
      hazard in health care. Routine testing of source patients for blood borne viruses
      where exposure has occurred is recommended in the UK. Whilst in practice source
      patient identification may be challenging the reasons why identified individuals 
      are not tested, including issues relating to consent and procedure compliance,
      are not fully understood. AIMS: To identify the frequency of serological testing 
      in identified source patients and the reasons for not testing, including refusal 
      and absence of consent. METHODS: A review of all BBF exposure incidents reported 
      to the Sheffield Occupational Health Service between 1 January 2009 and 31
      December 2009. RESULTS: Of 490 reported BBF exposure incidents source patients
      were identified in 87% of cases and tested in 56% of the incidents. Rates of
      source patient testing were higher following incidents affecting medical (76%)
      and nursing staff (69%) than those involving non-clinical (36%) and dental staff 
      (17%). Reasons for not testing source serology among identifiable patients (151) 
      were not recorded in 66% of incidents, in 20% there was incapacity to give
      consent and in 5% testing was refused. CONCLUSIONS: This study found that despite
      guidance, routine source testing is not universal. Incapacity to consent is a
      contributory factor for some source serology not being tested and clarification
      of the ethical and legal position would be helpful. Larger studies should explore
      other reasons why identified source patients are not tested in practice and
      explore the policy implications of those findings.
FAU - Giri, P
AU  - Giri P
AD  - Sheffield Occupational Health Service, Northern General Hospital, Sheffield
      Teaching Hospitals, NHS Foundation Trust, Silverwood S5 7AU, UK.
      prosenjitgiri@hotmail.com
FAU - Basu, S
AU  - Basu S
FAU - Adisesh, A
AU  - Adisesh A
FAU - Rimmer, A
AU  - Rimmer A
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121220
PL  - England
TA  - Occup Med (Lond)
JT  - Occupational medicine (Oxford, England)
JID - 9205857
SB  - IM
MH  - Blood-Borne Pathogens
MH  - Body Fluids/virology
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Infectious Disease Transmission, Patient-to-Professional/economics/*statistics & 
      numerical data
MH  - Informed Consent/*ethics
MH  - Needlestick Injuries/economics/psychology
MH  - Occupational Exposure/economics/*statistics & numerical data
EDAT- 2012/12/22 06:00
MHDA- 2013/12/27 06:00
CRDT- 2012/12/22 06:00
PHST- 2012/12/22 06:00 [entrez]
PHST- 2012/12/22 06:00 [pubmed]
PHST- 2013/12/27 06:00 [medline]
AID - kqs210 [pii]
AID - 10.1093/occmed/kqs210 [doi]
PST - ppublish
SO  - Occup Med (Lond). 2013 Mar;63(2):135-7. doi: 10.1093/occmed/kqs210. Epub 2012 Dec
      20.


PMID- 23256847
OWN - NLM
STAT- MEDLINE
DCOM- 20130311
LR  - 20211021
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 13
DP  - 2012 Dec 20
TI  - Use of next generation sequencing technologies in research and beyond: are
      participants with mental health disorders fully protected?
PG  - 36
LID - 10.1186/1472-6939-13-36 [doi]
AB  - BACKGROUND: Next Generation Sequencing (NGS) is expected to help find the
      elusive, causative genetic defects associated with Bipolar Disorder (BD). This
      article identifies the importance of NGS and further analyses the social and
      ethical implications of this approach when used in research projects studying BD,
      as well as other psychiatric ailments, with a view to ensuring the protection of 
      research participants. METHODS: We performed a systematic review of studies
      through PubMed, followed by a manual search through the titles and abstracts of
      original articles, including the reviews, commentaries and letters published in
      the last five years and dealing with the ethical and social issues raised by NGS 
      technologies and genomics studies of mental disorders, especially BD. A total of 
      217 studies contributed to identify the themes discussed herein. RESULTS: The
      amount of information generated by NGS renders individuals suffering from BD
      particularly vulnerable, and increases the need for educational support
      throughout the consent process, and, subsequently, of genetic counselling, when
      communicating individual research results and incidental findings to them. Our
      results highlight the importance and difficulty of respecting participants'
      autonomy while avoiding any therapeutic misconception. We also analysed the need 
      for specific regulations on the use and communication of incidental findings, as 
      well as the increasing influence of NGS in health care. CONCLUSIONS: Shared
      efforts on the part of researchers and their institutions, Research Ethics Boards
      as well as participants' representatives are needed to delineate a tailored
      consent process so as to better protect research participants. However, health
      care professionals involved in BD care and treatment need to first determine the 
      scientific validity and clinical utility of NGS-generated findings, and
      thereafter their prevention and treatment significance.
FAU - Groisman, Iris Jaitovich
AU  - Groisman IJ
AD  - Groupe de recherche Omics-Ethics, Programmes de bioethique, Faculte de medecine, 
      Universite de Montreal, C.P. 6128, succ. Centre-ville, Montreal, H3C 3J7, Canada.
FAU - Mathieu, Ghislaine
AU  - Mathieu G
FAU - Godard, Beatrice
AU  - Godard B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20121220
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Bipolar Disorder/*genetics
MH  - Consent Forms
MH  - Decision Making/ethics
MH  - Ethics, Research
MH  - Genetic Counseling/ethics
MH  - Genetic Research/*ethics
MH  - Humans
MH  - Incidental Findings
MH  - Informed Consent/*ethics
MH  - Personal Autonomy
MH  - Research Subjects
MH  - Sequence Analysis/*ethics
MH  - *Vulnerable Populations
PMC - PMC3537639
EDAT- 2012/12/22 06:00
MHDA- 2013/03/12 06:00
CRDT- 2012/12/22 06:00
PHST- 2012/04/22 00:00 [received]
PHST- 2012/12/10 00:00 [accepted]
PHST- 2012/12/22 06:00 [entrez]
PHST- 2012/12/22 06:00 [pubmed]
PHST- 2013/03/12 06:00 [medline]
AID - 1472-6939-13-36 [pii]
AID - 10.1186/1472-6939-13-36 [doi]
PST - epublish
SO  - BMC Med Ethics. 2012 Dec 20;13:36. doi: 10.1186/1472-6939-13-36.


PMID- 23256407
OWN - NLM
STAT- MEDLINE
DCOM- 20130104
LR  - 20121221
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 23
IP  - 3
DP  - 2012 Fall
TI  - Which patient groups should be asked to participate in first-in-human trials of
      stem-cell-based therapies?
PG  - 256-71
AB  - The aims of this article are to consider (1) whether there are medical and
      societal differences among diseases regarding which patient groups should be
      asked to participate in first-in-human (FIH) trials of stem-cell-based therapies;
      (2) any differences in the light of values generally endorsed by different types 
      of ethical theories, since the question in the title of this article is value
      laden, and its answer depends on which values one wants to promote and protect,
      and how they are ranked in importance; (3) whether the answer to that question is
      disease-specific, or whether it depends on factors common to several diseases. To
      illustrate these problems, we use Parkinson's disease (PD) and Huntington's
      disease (HD), between which there are important medical and societal differences.
      Moreover, research on stem-cell-based therapies for these diseases is being
      translated from research to practice. This approach to the problem can be applied
      to decision making about similar problems raised by other diseases that exhibit
      the same types of differences.
FAU - Hug, Kristina
AU  - Hug K
AD  - Department of Medical Ethics, Faculty of Medicine, Lund University, Lund, Sweden.
      Kristina.Hug@med.lu.se
FAU - Hermeren, Goran
AU  - Hermeren G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
MH  - Caregivers
MH  - Clinical Trials, Phase I as Topic/*ethics
MH  - Cost of Illness
MH  - Decision Making/ethics
MH  - Family Relations
MH  - Humans
MH  - *Huntington Disease/nursing/psychology/surgery
MH  - Life Expectancy
MH  - *Parkinson Disease/nursing/psychology/surgery
MH  - Patient Selection/*ethics
MH  - Personhood
MH  - Quality of Life
MH  - Stem Cell Transplantation/*ethics
MH  - Stress, Psychological/*etiology
EDAT- 2012/12/22 06:00
MHDA- 2013/01/05 06:00
CRDT- 2012/12/22 06:00
PHST- 2012/12/22 06:00 [entrez]
PHST- 2012/12/22 06:00 [pubmed]
PHST- 2013/01/05 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2012 Fall;23(3):256-71.


PMID- 23256406
OWN - NLM
STAT- MEDLINE
DCOM- 20130104
LR  - 20181202
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 23
IP  - 3
DP  - 2012 Fall
TI  - Quality of life and elective C-sections: defining limits to maternal and family
      interests.
PG  - 252-5
AB  - The author analyzes the lessons for ethics consultants presented by McCrary and
      colleagues in their case, "Elective Delivery Before 39 Weeks' Gestation:
      Reconciling Maternal, Fetal, and Family Interests in Challenging Circumstances." 
      Clinical ethics cases that involve different specialists representing the best
      interests of different parties in a case, such as this case involving
      neonatologists and perinatologists, are complex and time-consuming. The author
      concludes that ethics must insure the interests of the fetus and future person
      are not subsumed to the interests of those with a voice, without deliberate
      reflection and strong ethical justification.
FAU - Spike, Jeffrey P
AU  - Spike JP
AD  - McGovern Center for Humanities and Ethics, University of Texas-Houston, USA.
      Jeffrey.P.Spike@uth.tmc.edu
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
CON - J Clin Ethics. 2012 Fall;23(3):241-51. PMID: 23256405
MH  - *Cesarean Section
MH  - Decision Making/*ethics
MH  - *Ethics Consultation
MH  - *Family
MH  - Female
MH  - Humans
MH  - *Infant, Premature
MH  - *Intensive Care, Neonatal
MH  - Male
MH  - *Parents
MH  - *Patient Care Team
MH  - Physician-Patient Relations/*ethics
MH  - Pregnancy
MH  - *Premature Birth
EDAT- 2012/12/22 06:00
MHDA- 2013/01/05 06:00
CRDT- 2012/12/22 06:00
PHST- 2012/12/22 06:00 [entrez]
PHST- 2012/12/22 06:00 [pubmed]
PHST- 2013/01/05 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2012 Fall;23(3):252-5.


PMID- 23256405
OWN - NLM
STAT- MEDLINE
DCOM- 20130104
LR  - 20121221
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 23
IP  - 3
DP  - 2012 Fall
TI  - Elective delivery before 39 weeks' gestation: reconciling maternal, fetal, and
      family interests in challenging circumstances.
PG  - 241-51
AB  - We present the case of a 36-year-old woman who has experienced three lost
      pregnancies; during the most recent loss, a full term pregnancy, she almost died 
      from complications of placental abruption. She is now completing the 34th week of
      gestation and is experiencing symptoms similar to those under which she lost the 
      previous pregnancy. Despite a lack of specific medical indications, the patient
      and her husband firmly but politely request that the attending
      obstetrician/perinatologist perform an immediate cesarean section in order to
      alleviate the couple's anxiety about possibly never having a family. Discussing
      the case are an experienced perinatologist, a neonatologist, a regional perinatal
      center coordinator, and a clinical ethicist.
FAU - Van McCrary, S
AU  - Van McCrary S
AD  - Center for Medical Humanities, Compassionate Care, and Bioethics, Department of
      Preventive Medicine, Stony Brook University Medical Center, Stony Brook, New
      York, USA. stephen.v.mccrary@stonybrook.edu
FAU - Shah, Shetal I
AU  - Shah SI
FAU - Combs, Adriann
AU  - Combs A
FAU - Quirk, J Gerald
AU  - Quirk JG
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
CIN - J Clin Ethics. 2012 Fall;23(3):252-5. PMID: 23256406
MH  - Abortion, Spontaneous
MH  - Abruptio Placentae/prevention & control
MH  - Adult
MH  - *Cesarean Section
MH  - Choice Behavior/ethics
MH  - Cognition
MH  - Decision Making/*ethics
MH  - Disabled Persons
MH  - Emotions
MH  - *Ethics Consultation/standards
MH  - *Family
MH  - Female
MH  - Fetal Death
MH  - Health Care Costs
MH  - Humans
MH  - Infant, Newborn
MH  - *Infant, Premature
MH  - *Intensive Care, Neonatal/economics/methods
MH  - Male
MH  - *Parents/psychology
MH  - *Patient Care Team/ethics
MH  - Physician-Patient Relations/*ethics
MH  - Pregnancy
MH  - *Premature Birth/economics
MH  - United States
EDAT- 2012/12/22 06:00
MHDA- 2013/01/05 06:00
CRDT- 2012/12/22 06:00
PHST- 2012/12/22 06:00 [entrez]
PHST- 2012/12/22 06:00 [pubmed]
PHST- 2013/01/05 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2012 Fall;23(3):241-51.


PMID- 23256404
OWN - NLM
STAT- MEDLINE
DCOM- 20130104
LR  - 20121221
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 23
IP  - 3
DP  - 2012 Fall
TI  - HCEC pearls and pitfalls: suggested do's and don't's for healthcare ethics
      consultants.
PG  - 234-40
AB  - Members of the Clinical Ethics Consultation Affairs Standing Committee of the
      American Society for Bioethics and Humanities present a collection of insights
      and recommendations developed from their collective experience, intended for
      those engaged in the work of healthcare ethics consultation.
CN  - American Society for Bioethics and Humanities Clinical Ethics Consultation
      Affairs Standing Committee
AD  - Division of General Internal Medicine, Johns Hopkins School of Medicine,
      Baltimore, Maryland, USA. jcarrese@jhmi.edu
FAU - Carrese, Joseph A
AU  - Carrese JA
FAU - Antommaria, Armand H Matheny
AU  - Antommaria AH
FAU - Berkowitz, Kenneth A
AU  - Berkowitz KA
FAU - Berger, Jeffrey
AU  - Berger J
FAU - Carrese, Joseph
AU  - Carrese J
FAU - Childs, Brian H
AU  - Childs BH
FAU - Derse, Arthur R
AU  - Derse AR
FAU - Gallagher, Colleen
AU  - Gallagher C
FAU - Gallagher, John A
AU  - Gallagher JA
FAU - Goodman-Crews, Paula
AU  - Goodman-Crews P
FAU - Heesters, Ann
AU  - Heesters A
FAU - Jurchak, Martha
AU  - Jurchak M
FAU - Mitchell, Christine
AU  - Mitchell C
FAU - Mokwyune, Nneka
AU  - Mokwyune N
FAU - Parsi, Kayhan
AU  - Parsi K
FAU - Powell, Tia
AU  - Powell T
FAU - Powderly, Kathleen E
AU  - Powderly KE
FAU - Rosell, Tarris
AU  - Rosell T
FAU - Shelton, Wayne
AU  - Shelton W
FAU - Smith, Martin L
AU  - Smith ML
FAU - Spike, Jeffrey
AU  - Spike J
FAU - Tarzian, Anita
AU  - Tarzian A
FAU - Wocial, Lucia
AU  - Wocial L
LA  - eng
PT  - Guideline
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
MH  - Bioethics
MH  - Ethicists/*standards
MH  - Ethics Committees/standards
MH  - Ethics Consultation/organization & administration/*standards
MH  - Ethics, Medical
MH  - Humans
MH  - United States
EDAT- 2012/12/22 06:00
MHDA- 2013/01/05 06:00
CRDT- 2012/12/22 06:00
PHST- 2012/12/22 06:00 [entrez]
PHST- 2012/12/22 06:00 [pubmed]
PHST- 2013/01/05 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2012 Fall;23(3):234-40.


PMID- 23256403
OWN - NLM
STAT- MEDLINE
DCOM- 20130104
LR  - 20181202
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 23
IP  - 3
DP  - 2012 Fall
TI  - The rose of Sharon: what is the ideal timing for palliative care consultation
      versus ethics consultation?
PG  - 231-3
AB  - Ethics committees and palliative care consultants can function in a complementary
      fashion, seamlessly and effectively. Ethics committees can "air" and help
      resolves issues, and palliative care consultants can use a low-key, longitudinal 
      approach.
FAU - La Via, Jennifer
AU  - La Via J
AD  - Theda Clark Medical Center, Neenah, Wisconsin, USA. Jennifer.LaVia@Thedacare.org
FAU - Schiedermayer, David
AU  - Schiedermayer D
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
CON - J Clin Ethics. 2012 Fall;23(3):224-30. PMID: 23256402
MH  - Decision Making/*ethics
MH  - *Ethics Committees, Clinical
MH  - *Ethics Consultation
MH  - *Fathers
MH  - Humans
MH  - *Mothers
MH  - Palliative Care/*ethics
MH  - *Parental Consent
MH  - Patient Care Team/*ethics
EDAT- 2012/12/22 06:00
MHDA- 2013/01/05 06:00
CRDT- 2012/12/22 06:00
PHST- 2012/12/22 06:00 [entrez]
PHST- 2012/12/22 06:00 [pubmed]
PHST- 2013/01/05 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2012 Fall;23(3):231-3.


PMID- 23256402
OWN - NLM
STAT- MEDLINE
DCOM- 20130104
LR  - 20121221
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 23
IP  - 3
DP  - 2012 Fall
TI  - Stories and the longitudinal patient relationship: what can clinical ethics
      consultants learn from palliative care?
PG  - 224-30
AB  - A case of conflict in pediatric end-of-life decision making is presented to
      compare the complementary roles of clinical ethics consultants and palliative
      care specialists. The progression of the case illustrates the differing
      structures, goals, and methods of the majority of such teams. The strengths of
      each of consultation are emphasized. Particularly in centers where palliative
      care services are not available, it can be important for careproviders and
      clinical ethics consultants to focus on alliance-building and a longitudinal
      relationship with patients and families.
FAU - Morrison, Wynne
AU  - Morrison W
AD  - Division of Critical Care and Palliative Care, Children's Hospital of
      Philadelphia, USA. morrisonw@email.chop.edu
FAU - Derrington, Sabrina F
AU  - Derrington SF
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
CIN - J Clin Ethics. 2012 Fall;23(3):231-3. PMID: 23256403
MH  - Choice Behavior/ethics
MH  - Decision Making/*ethics
MH  - Ethicists/standards
MH  - *Ethics Committees, Clinical
MH  - *Ethics Consultation
MH  - Ethics, Medical
MH  - *Fathers
MH  - Foster Home Care
MH  - Humans
MH  - Medical Futility
MH  - *Mothers
MH  - Narration
MH  - Palliative Care/*ethics/methods
MH  - *Parental Consent/ethics
MH  - Patient Care Team/*ethics
EDAT- 2012/12/22 06:00
MHDA- 2013/01/05 06:00
CRDT- 2012/12/22 06:00
PHST- 2012/12/22 06:00 [entrez]
PHST- 2012/12/22 06:00 [pubmed]
PHST- 2013/01/05 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2012 Fall;23(3):224-30.


PMID- 23256401
OWN - NLM
STAT- MEDLINE
DCOM- 20130104
LR  - 20181202
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 23
IP  - 3
DP  - 2012 Fall
TI  - Regulatory misconception muddies the ethical waters: challenges to a qualitative 
      study.
PG  - 217-20; discussion 221-3
AB  - In "Potential Subjects' Responses to an Ethics Questionnaire in a Phase I Study
      of Deep-Brain Stimulation in Early Parkinson's Disease," Finder, Bliton, Gill,
      Davis, Konrad, and Charles undertake informed consent research on what they
      describe as a Phase I trial of deep brain stimulation (DBS) for Parkinson's
      disease. We argue that the authors should have more carefully characterized the
      nature of the DBS study at the start of their clinical study.
FAU - Yee, Kimberly M
AU  - Yee KM
AD  - Cleveland Clinic NeuoEthics Program in Cleveland, Ohio, USA.
FAU - Ford, Paul J
AU  - Ford PJ
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
CON - J Clin Ethics. 2012 Fall;23(3):207-16. PMID: 23256400
MH  - *Comprehension
MH  - *Decision Making
MH  - *Deep Brain Stimulation
MH  - Female
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Male
MH  - Parkinson Disease/*therapy
MH  - Patients/*psychology
MH  - Research Subjects/*psychology
EDAT- 2012/12/22 06:00
MHDA- 2013/01/05 06:00
CRDT- 2012/12/22 06:00
PHST- 2012/12/22 06:00 [entrez]
PHST- 2012/12/22 06:00 [pubmed]
PHST- 2013/01/05 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2012 Fall;23(3):217-20; discussion 221-3.


PMID- 23256400
OWN - NLM
STAT- MEDLINE
DCOM- 20130104
LR  - 20211021
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 23
IP  - 3
DP  - 2012 Fall
TI  - Potential subjects' responses to an ethics questionnaire in a phase I study of
      deep brain stimulation in early Parkinson's disease.
PG  - 207-16
AB  - BACKGROUND: Central to ethically justified clinical trial design is the need for 
      an informed consent process responsive to how potential subjects actually
      comprehend study participation, especially study goals, risks, and potential
      benefits. This will be particularly challenging when studying deep brain
      stimulation and whether it impedes symptom progression in Parkinson's disease,
      since potential subjects will be Parkinson's patients for whom deep brain
      stimulation will likely have therapeutic value in the future as their disease
      progresses. METHOD: As part of an expanded informed consent process for a pilot
      Phase I study of deep brain stimulation in early stage Parkinson's disease, an
      ethics questionnaire composed of 13 open-ended questions was distributed to
      potential subjects. The questionnaire was designed to guide potential subjects in
      thinking about their potential participation. RESULTS: While the purpose of the
      study (safety and tolerability) was extensively presented during the informed
      consent process, in returned responses 70 percent focused on effectiveness and 91
      percent included personal benefit as poten- tial benefit from enrolling. However,
      91 percent also indicated helping other Parkinson's patients as motivation when
      considering whether or not to enroll. CONCLUSIONS: This combination of responses 
      highlights two issues to which investigators need to pay close attention in
      future trial designs: (1) how, and in what ways, informed consent processes
      reinforce potential subjects' preconceived understandings of benefit, and (2)
      that potential subjects see themselves as part of a community of Parkinson's
      sufferers with responsibilities extending beyond self-interest. More importantly,
      it invites speculation that a different paradigm for informed consent may be
      needed.
FAU - Finder, Stuart G
AU  - Finder SG
AD  - Cedars-Sinai Medical Center, Los Angeles, California, USA. stuart.finder@cshs.org
FAU - Bliton, Mark J
AU  - Bliton MJ
FAU - Gill, Chandler E
AU  - Gill CE
FAU - Davis, Thomas L
AU  - Davis TL
FAU - Konrad, Peter E
AU  - Konrad PE
FAU - Charles, P David
AU  - Charles PD
LA  - eng
GR  - KL2 RR024977/RR/NCRR NIH HHS/United States
GR  - TL1 RR024978/RR/NCRR NIH HHS/United States
GR  - UL1 RR024975/RR/NCRR NIH HHS/United States
GR  - 1 UL1 RR024975/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
CIN - J Clin Ethics. 2012 Fall;23(3):217-20; discussion 221-3. PMID: 23256401
MH  - Adult
MH  - Aged
MH  - Clinical Trials, Phase I as Topic
MH  - *Comprehension
MH  - *Decision Making
MH  - *Deep Brain Stimulation/adverse effects
MH  - Female
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Male
MH  - Middle Aged
MH  - Parkinson Disease/*therapy
MH  - Patients/*psychology/statistics & numerical data
MH  - Research Subjects/*psychology
MH  - Surveys and Questionnaires
EDAT- 2012/12/22 06:00
MHDA- 2013/01/05 06:00
CRDT- 2012/12/22 06:00
PHST- 2012/12/22 06:00 [entrez]
PHST- 2012/12/22 06:00 [pubmed]
PHST- 2013/01/05 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2012 Fall;23(3):207-16.


PMID- 23256399
OWN - NLM
STAT- MEDLINE
DCOM- 20130104
LR  - 20121221
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 23
IP  - 3
DP  - 2012 Fall
TI  - An ethical priority greater than life itself.
PG  - 195-206
AB  - This article discusses a case in this issue of The Journal of Clinical Ethics by 
      McCrary and colleagues, "Elective Delivery Before 39 Weeks' Gestation Reconciling
      Maternal, Fetal, and Family Circumstances," in which parents asked the medical
      team to deliver their fetus "early." The author discusses (1) the importance that
      parents have to a child when they are able to love the child, and how important
      it is for decision makers to consider this; (2) exceptional approaches that may
      enable parents to "change their minds"; and (3) substantive and procedural
      innovations that may help to prevent clinicians' views from playing too big a
      role and/or being arbitrary. The author concludes by describing how he felt when 
      reading the case and uses this to illustrate how clinicians may benefit by
      assessing their feelings.
FAU - Howe, Edmund G
AU  - Howe EG
AD  - Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
MH  - Abortion, Spontaneous
MH  - Abruptio Placentae/prevention & control
MH  - Adult
MH  - Choice Behavior/ethics
MH  - Cognition
MH  - Decision Making/*ethics
MH  - *Disabled Persons
MH  - *Emotions
MH  - Ethicists/standards
MH  - Ethics Consultation/standards
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - *Infant, Premature
MH  - Male
MH  - *Parents/psychology
MH  - Patient Care Team/ethics
MH  - Physician-Patient Relations/*ethics
MH  - Physicians/ethics/*psychology
MH  - Pregnancy
MH  - *Premature Birth
MH  - Stillbirth
MH  - United States
EDAT- 2012/12/22 06:00
MHDA- 2013/01/05 06:00
CRDT- 2012/12/22 06:00
PHST- 2012/12/22 06:00 [entrez]
PHST- 2012/12/22 06:00 [pubmed]
PHST- 2013/01/05 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2012 Fall;23(3):195-206.


PMID- 23256397
OWN - NLM
STAT- MEDLINE
DCOM- 20130110
LR  - 20150826
IS  - 0792-9935 (Print)
IS  - 0792-9935 (Linking)
VI  - 29
IP  - 3
DP  - 2012 Jul
TI  - [Distribution of patients' complaints presented to the law court of the Israel
      Dental Association according to themes, dental area profession and the results].
PG  - 47-53, 58
AB  - The purpose of this study was to review the distribution of patients' complains
      presented to the law court of the Israel Dental Association in Tel Aviv district,
      according to their topics, dental areas and results. 260 complaint cases filed
      between 2000 and July 2008 were reviewed. only 186 cases, to which an arbitration
      proceeding conducted full appeal only, were taken into account . Dentists, who
      encountered many complaints, were classified according to their country of
      graduation, as specialists or general dentists. The complaints were classified
      according to their specific dental field, year of complaint, to the number of
      arbitrations each year, to the number of appeals each year, to the entity who
      submitted the appeal, to the difference between the verdict in the District
      compared to the national ruling, to the distribution of complaints by gender and 
      to the frequency of complaints by anonymous doctors. The distribution of
      complaints in accordance with topics was as follows: 30% in oral rehabilitation
      13.5% in Dental prosthesis, 12.4% in implants, in endodontics 5.3%, 3.7% in
      maxillofacial surgery, 3.2% on ethics, 2.7% in orthodontics, 1.1% in
      periodontology 0.5 % in pedodontics and 28% in combined dental domains. 92.5% of 
      complaints filed against dentists who were not experts. 7.5% of the complaints
      were filed against s specialists. Specialists in the field of oral rehabilitation
      encountered the largest number of complaints, i.c. 30%. Approximately 35.2% of
      complaints filed against dentists who have completed their studies in Eastern
      European countries and 24.9% against the Israeli graduates. 63% of referrals to
      the Court from Tel Aviv district for which a full arbitration procedure / appeals
      were presented by women whereas only 37% were presented by men. An analysis of
      the findings in the difference between the verdicts in the District compared to
      the national ruling it showed a tendency to aggravation of punishment. (P =
      0.003) The Greatest number of appeals was filed in 2001, mostly by patients. In
      2004, the greatest number of appeals were filed mostly by dentists. Most appeals 
      have been filed over the years by patients. Against a small number of doctors
      several complaints were filed. The majority of complaints that were filed in a
      specific period against one doctor was 6.
FAU - Halperin, E
AU  - Halperin E
AD  - Dept. of Oral Pathology and Oral Medicine, Maurice and Gabriela Goldshleger
      School of Dental Medicine, Tel Aviv University, Tel aviv, Israel.
FAU - Kaffe, I
AU  - Kaffe I
FAU - Gordon, M
AU  - Gordon M
LA  - heb
PT  - English Abstract
PT  - Journal Article
PL  - Israel
TA  - Refuat Hapeh Vehashinayim (1993)
JT  - Refu'at ha-peh veha-shinayim (1993)
JID - 9816240
MH  - Dentistry/standards/*statistics & numerical data
MH  - Female
MH  - General Practice, Dental/legislation & jurisprudence/standards/*statistics &
      numerical data
MH  - Humans
MH  - Israel
MH  - Legislation, Dental/statistics & numerical data
MH  - Male
MH  - *Societies, Dental
MH  - Specialties, Dental/statistics & numerical data
EDAT- 2012/12/22 06:00
MHDA- 2013/01/11 06:00
CRDT- 2012/12/22 06:00
PHST- 2012/12/22 06:00 [entrez]
PHST- 2012/12/22 06:00 [pubmed]
PHST- 2013/01/11 06:00 [medline]
PST - ppublish
SO  - Refuat Hapeh Vehashinayim (1993). 2012 Jul;29(3):47-53, 58.


PMID- 23255961
OWN - NLM
STAT- MEDLINE
DCOM- 20131202
LR  - 20211021
IS  - 1860-3572 (Electronic)
IS  - 1860-3572 (Linking)
VI  - 29
IP  - 5
DP  - 2012
TI  - Participant observation and change of perspectives: medical anthropology and the 
      encounter with socially marginalised groups. First experiences with a new
      teaching concept.
PG  - Doc66
LID - 10.3205/zma000836 [doi]
AB  - This paper examines the new teaching concept "Providing medical care on the
      fringe of society: Participant observation and change in perspectives" in the
      context of the interdisciplinary field of Querschnittsbereich 2/Q 2 (the
      transdisciplinary section under AOA, the German Regulations for licensed
      physicians) that explores the history, theory and ethics of medicine. The
      disciplinary approach usually adopted in Q 2 is supplemented with concepts from
      medical anthropology; in addition students will be exposed to people in extreme
      social situations. The aim is to make students aware of and invite them to
      reflect upon: the importance of participant observation in the specific on-site
      setting of medical thinking and acting; the importance of the subjectivity of all
      those involved in doctor/patient interaction; and the fact that key medical terms
      (such as the "need" as seen by the physician vs. the need as seen by the patient)
      are essentially context-dependent in their interpretation. At a more general
      level students will learn how to put themselves in the position of different
      protagonists in a range of medical settings, and practice the skill of reflecting
      critically upon putative conceptual/theoretical and normative-ethical assumptions
      in medicine.
FAU - Mohr, Berit
AU  - Mohr B
AD  - Universitat Giessen, Institut fur Geschichte der Medizin, Giessen, Germany.
FAU - Hovermann, Peter
AU  - Hovermann P
FAU - Roelcke, Volker
AU  - Roelcke V
LA  - eng
PT  - Journal Article
DEP - 20121115
PL  - Germany
TA  - GMS Z Med Ausbild
JT  - GMS Zeitschrift fur medizinische Ausbildung
JID - 101276035
SB  - IM
MH  - Anthropology, Medical/*education/ethics
MH  - *Attitude of Health Personnel
MH  - Curriculum
MH  - *Education, Medical/ethics
MH  - Ethics, Medical
MH  - *Faculty, Medical
MH  - Germany
MH  - Homeless Persons
MH  - Humans
MH  - *Social Marginalization
MH  - Teaching
PMC - PMC3525911
OTO - NOTNLM
OT  - Medical Anthropology
OT  - Medical Humanities
OT  - counter-transference
OT  - homeless people
OT  - participant observation
EDAT- 2012/12/21 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/12/21 06:00
PHST- 2012/01/30 00:00 [received]
PHST- 2012/06/22 00:00 [revised]
PHST- 2012/06/25 00:00 [accepted]
PHST- 2012/12/21 06:00 [entrez]
PHST- 2012/12/21 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.3205/zma000836 [doi]
AID - zma000836 [pii]
PST - ppublish
SO  - GMS Z Med Ausbild. 2012;29(5):Doc66. doi: 10.3205/zma000836. Epub 2012 Nov 15.


PMID- 23254869
OWN - NLM
STAT- MEDLINE
DCOM- 20130524
LR  - 20180802
IS  - 1424-3997 (Electronic)
IS  - 0036-7672 (Linking)
VI  - 142
DP  - 2012
TI  - Neuroenhancement - perspectives of Swiss psychiatrists and general practitioners.
PG  - w13707
LID - 10.4414/smw.2012.13707 [doi]
LID - Swiss Med Wkly. 2012;142:w13707 [pii]
AB  - QUESTIONS UNDER STUDY: Although the ethical and health implications of
      neuroenhancement have been intensely discussed over the past years, little is
      known about the experiences and attitudes of physicians confronted with requests 
      for neuroenhancing substances. The aim of this study was to explore general
      practitioners' and psychiatrists' familiarity with such requests and their
      willingness to prescribe these products. METHOD: A nation-wide cross-sectional
      survey among general practitioners and psychiatrists in Switzerland was
      conducted. A questionnaire was developed, pre-tested and sent out to a
      pre-defined sample of 1,600 Swiss practising physicians in the fields of
      psychiatry and general practice/internal medicine in the German-speaking and
      French-speaking part of Switzerland. RESULTS: A total of 393 questionnaires were 
      returned (response rate: 24.7%). 80.2% of study participants were encountered
      requests for neuroenhancing products in their own practice, mostly not exceeding 
      1-2 times a year. A total of 41.1% were undecided when asked if they
      categorically against neuroenhancement, 49% would decide on a case-by-case basis,
      and 9.6% would decide according to patients' wishes. CONCLUSIONS: Swiss
      psychiatrists and general practitioners are confronted with requests for
      neuroenhancement, albeit not very frequently. Most participants embrace a
      pragmatic position towards neuroenhancement, although there is also a
      considerable degree of uncertainty about the appropriateness of a categorical
      refusal. A minority would follow a consumer model that leaves the decision about 
      the use of neuroenhancers to the client, even though this conflicts with legal
      requirements regarding drug prescriptions.
FAU - Ott, Regula
AU  - Ott R
AD  - Institute of Biomedical Ethics, University of Zurich, Switzerland.
FAU - Lenk, Christian
AU  - Lenk C
FAU - Miller, Nicole
AU  - Miller N
FAU - Neuhaus Buhler, Rachel
AU  - Neuhaus Buhler R
FAU - Biller-Andorno, Nikola
AU  - Biller-Andorno N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121127
PL  - Switzerland
TA  - Swiss Med Wkly
JT  - Swiss medical weekly
JID - 100970884
RN  - 0 (Adrenergic beta-Antagonists)
RN  - 0 (Antidepressive Agents)
RN  - 0 (Central Nervous System Agents)
SB  - IM
MH  - Adrenergic beta-Antagonists/administration & dosage/standards
MH  - Analysis of Variance
MH  - Antidepressive Agents/administration & dosage/standards
MH  - *Attitude of Health Personnel
MH  - Biomedical Enhancement/ethics/methods
MH  - Central Nervous System Agents/*administration & dosage/standards
MH  - Cross-Sectional Studies
MH  - Female
MH  - General Practitioners/ethics/*statistics & numerical data
MH  - Humans
MH  - Male
MH  - Practice Patterns, Physicians'/ethics/*statistics & numerical data
MH  - Psychiatry/ethics/*statistics & numerical data
MH  - Surveys and Questionnaires
MH  - Switzerland
EDAT- 2012/12/21 06:00
MHDA- 2013/05/28 06:00
CRDT- 2012/12/21 06:00
PHST- 2012/12/21 06:00 [entrez]
PHST- 2012/12/21 06:00 [pubmed]
PHST- 2013/05/28 06:00 [medline]
AID - 10.4414/smw.2012.13707 [doi]
AID - smw-13707 [pii]
PST - epublish
SO  - Swiss Med Wkly. 2012 Nov 27;142:w13707. doi: 10.4414/smw.2012.13707. eCollection 
      2012.


PMID- 23254281
OWN - NLM
STAT- MEDLINE
DCOM- 20131021
LR  - 20151119
IS  - 1878-1799 (Electronic)
IS  - 1871-5192 (Linking)
VI  - 26
IP  - 2
DP  - 2013 Jun
TI  - 'How can we go on caring when nobody here cares about us?' Australian public
      maternity units as contested care sites.
PG  - 133-7
LID - 10.1016/j.wombi.2012.11.003 [doi]
LID - S1871-5192(12)00096-0 [pii]
AB  - BACKGROUND: Provision of personalised, continuous care focused on 'well women' is
      now central to midwifery identity and work ideals, but it remains difficult in
      hospital contexts shaped by increased demand and by neoliberal policies. Previous
      accounts of occupational and work-family conflicts in midwifery and nursing have 
      pointed to the 'moral distress' associated with managing conflicting expectations
      in health workplaces. QUESTION: This paper examines these issues in the
      Australian context and considers further the ethical implications of midwives not
      feeling 'cared for' themselves in health care organisations. METHODS: Qualitative
      research in several Victorian maternity units included use of interviews and
      observational methods to explore staff experiences of organisational and
      professional change. Data were coded and analysed using NVivo. FINDINGS: Midwives
      reported frequent contestation as they sought to practice their ideal of
      themselves as caregivers in what they reported as often 'uncaring' workplaces. To
      interpret this data, we argue for seeing midwifery caring as embodied social
      practice taking place within 'organisation carescapes'. CONCLUSION: Theoretical
      analysis of the moral and ethical dimensions of the contemporary organisational
      structure of maternity care suggests that a practice-based and dialogical ethic
      should form the core principle of care both for women in childbirth and for their
      carers.
CI  - Copyright (c) 2012 Australian College of Midwives. Published by Elsevier Ltd. All
      rights reserved.
FAU - Reiger, Kerreen
AU  - Reiger K
AD  - School of Social Sciences, La Trobe University, 3086, Australia.
      k.reiger@latrobe.edu.au
FAU - Lane, Karen
AU  - Lane K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121217
PL  - Netherlands
TA  - Women Birth
JT  - Women and birth : journal of the Australian College of Midwives
JID - 101266131
MH  - Adult
MH  - Attitude of Health Personnel
MH  - Australia
MH  - Caregivers/*psychology
MH  - Female
MH  - Hospitals, Maternity
MH  - Humans
MH  - Interviews as Topic
MH  - Nurse Midwives/*psychology
MH  - Occupational Health
MH  - Pregnancy
MH  - Qualitative Research
MH  - *Stress, Psychological
MH  - Surveys and Questionnaires
MH  - Workload
MH  - Workplace
EDAT- 2012/12/21 06:00
MHDA- 2013/10/22 06:00
CRDT- 2012/12/21 06:00
PHST- 2012/06/10 00:00 [received]
PHST- 2012/11/08 00:00 [revised]
PHST- 2012/11/13 00:00 [accepted]
PHST- 2012/12/21 06:00 [entrez]
PHST- 2012/12/21 06:00 [pubmed]
PHST- 2013/10/22 06:00 [medline]
AID - S1871-5192(12)00096-0 [pii]
AID - 10.1016/j.wombi.2012.11.003 [doi]
PST - ppublish
SO  - Women Birth. 2013 Jun;26(2):133-7. doi: 10.1016/j.wombi.2012.11.003. Epub 2012
      Dec 17.


PMID- 23253725
OWN - NLM
STAT- MEDLINE
DCOM- 20131203
LR  - 20121220
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Linking)
VI  - 125
IP  - 24
DP  - 2012 Dec
TI  - Prospective use of skin-derived precursors in neural regeneration.
PG  - 4488-96
AB  - OBJECTIVE: To review recent studies concerning the origins of skin-derived
      precursors (SKPs), their differentiation characteristics, and their potential
      application in neural regenerative medicine. DATA SOURCES: Data were retrieved
      from studies reported in PubMed published between April, 1974 and June, 2012. The
      search terms used were "skin-derived precursors", "stem cells", and "neural
      diseases". STUDY SELECTION: Articles were included in the review if they were
      relevant to SKPs as stem cells, as well as their applications in neural
      regenerative medicine, such as in the treatment of spinal cord injury,
      Parkinson's disease, spinal muscular atrophy and Shah-Waardenburg syndrome.
      RESULTS: SKPs are a novel population of neural crest-derived precursors that
      arise during embryogenesis and persist into adulthood. They can generate both
      neural cells and mesodermal lineage cells (including smooth muscle cells and
      adipocytes). Compared with other stem cells, SKPs are abundant in adult skin, can
      differentiate easily into neural cells, and are not associated with any ethical
      controversies. CONCLUSION: SKPs may provide an alternative source of stem cells
      to embryonic stem cells for transplantation therapy for neurological diseases.
FAU - Lu, Xiao-cheng
AU  - Lu XC
AD  - Department of Neurosurgery, First Affiliated Hospital of Nanjing Medical
      University, Nanjing, Jiangsu, China.
FAU - Tao, Yi
AU  - Tao Y
FAU - Li, Li-xin
AU  - Li LX
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
SB  - IM
MH  - Animals
MH  - Cell Differentiation/physiology
MH  - Humans
MH  - Nerve Regeneration/*physiology
MH  - Skin/*cytology
MH  - Stem Cells/*cytology
EDAT- 2012/12/21 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/12/21 06:00
PHST- 2012/12/21 06:00 [entrez]
PHST- 2012/12/21 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
PST - ppublish
SO  - Chin Med J (Engl). 2012 Dec;125(24):4488-96.


PMID- 23253685
OWN - NLM
STAT- MEDLINE
DCOM- 20131017
LR  - 20131121
IS  - 1578-1267 (Electronic)
IS  - 0301-0546 (Linking)
VI  - 41
IP  - 4
DP  - 2013 Jul-Aug
TI  - Asthma and paracetamol: could we really know what happens between them?
PG  - 261-4
LID - 10.1016/j.aller.2012.07.012 [doi]
LID - S0301-0546(12)00292-3 [pii]
AB  - An association between paracetamol use or exposure in different times of life,
      including gestation and childhood, and asthma has been observed in recent years. 
      Causality cannot be established from observational studies because of the
      arguable presence of many confounding factors and biases. Randomised trials are
      needed to disclose the nature of the association, but are difficult to carry out 
      because of ethic, economic and logistical issues as large patient samples should 
      be involved for a long time in such studies. Pragmatic trials may be the best
      option to shed some light on this issue. Questions regarding the problems and
      difficulties of conducting such trials and the way to overcome them are
      discussed.
CI  - Copyright (c) 2012 SEICAP. Published by Elsevier Espana. All rights reserved.
FAU - Moral, L
AU  - Moral L
AD  - Pediatric Allergy and Respiratory Unit, Hospital General Universitario de
      Alicante, Spain. lmoralg@gmail.com
FAU - Marco, N
AU  - Marco N
FAU - Fuentes, M J
AU  - Fuentes MJ
FAU - Toral, T
AU  - Toral T
FAU - Cano, R
AU  - Cano R
FAU - Pena, M A
AU  - Pena MA
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121217
PL  - Singapore
TA  - Allergol Immunopathol (Madr)
JT  - Allergologia et immunopathologia
JID - 0370073
RN  - 0 (Analgesics, Non-Narcotic)
RN  - 362O9ITL9D (Acetaminophen)
SB  - IM
MH  - Acetaminophen/*adverse effects
MH  - Analgesics, Non-Narcotic/*adverse effects
MH  - Asthma/*chemically induced
MH  - Causality
MH  - Clinical Trials as Topic/*methods
MH  - Humans
MH  - Multicenter Studies as Topic
MH  - Randomized Controlled Trials as Topic
MH  - Research Design
OTO - NOTNLM
OT  - Asthma
OT  - Clinical trials
OT  - Epidemiological studies
OT  - Paracetamol
EDAT- 2012/12/21 06:00
MHDA- 2013/10/18 06:00
CRDT- 2012/12/21 06:00
PHST- 2012/06/15 00:00 [received]
PHST- 2012/07/22 00:00 [accepted]
PHST- 2012/12/21 06:00 [entrez]
PHST- 2012/12/21 06:00 [pubmed]
PHST- 2013/10/18 06:00 [medline]
AID - S0301-0546(12)00292-3 [pii]
AID - 10.1016/j.aller.2012.07.012 [doi]
PST - ppublish
SO  - Allergol Immunopathol (Madr). 2013 Jul-Aug;41(4):261-4. doi:
      10.1016/j.aller.2012.07.012. Epub 2012 Dec 17.


PMID- 23253665
OWN - NLM
STAT- MEDLINE
DCOM- 20130731
LR  - 20211203
IS  - 1752-8062 (Electronic)
IS  - 1752-8054 (Linking)
VI  - 5
IP  - 6
DP  - 2012 Dec
TI  - Values in translation: how asking the right questions can move translational
      science toward greater health impact.
PG  - 445-51
LID - 10.1111/j.1752-8062.2012.00441.x [doi]
AB  - The speed and effectiveness of current approaches to research translation are
      widely viewed as disappointing given small gains in real population health
      outcomes despite huge investments in basic and translational science. We identify
      critical value questions-ethical, social, economic, and cultural-that arise at
      moments throughout the research pathway. By making these questions visible, and
      promoting discussion of them with diverse stakeholders, we can facilitate
      handoffs along the translational pathway and increase uptake of effective
      interventions. Who is involved with those discussions will determine which
      research projects, populations, and methods get prioritized. We argue that some
      upfront investment in community and interdisciplinary engagement, shaped by
      familiar questions in ethics, social justice, and cultural knowledge, can save
      time and resources in the long run because interventions and strategies will be
      aimed in the right direction, that is, toward health improvements for all.
CI  - (c) 2012 Wiley Periodicals, Inc.
FAU - Kelley, Maureen
AU  - Kelley M
AD  - Treuman Katz Center for Pediatric Bioethics, Seattle Children's Hospital,
      Washington, USA. mckelley@u.washington.edu
FAU - Edwards, Kelly
AU  - Edwards K
FAU - Starks, Helene
AU  - Starks H
FAU - Fullerton, Stephanie M
AU  - Fullerton SM
FAU - James, Rosalina
AU  - James R
FAU - Goering, Sara
AU  - Goering S
FAU - Holland, Suzanne
AU  - Holland S
FAU - Disis, Mary L
AU  - Disis ML
FAU - Burke, Wylie
AU  - Burke W
LA  - eng
GR  - P50 HG003374/HG/NHGRI NIH HHS/United States
GR  - UL1 RR025014/RR/NCRR NIH HHS/United States
GR  - P50 HG3374/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20120807
PL  - United States
TA  - Clin Transl Sci
JT  - Clinical and translational science
JID - 101474067
SB  - IM
MH  - *Health
MH  - Humans
MH  - Judgment
MH  - *Translational Research, Biomedical
PMC - PMC3561695
EDAT- 2012/12/21 06:00
MHDA- 2013/08/01 06:00
CRDT- 2012/12/21 06:00
PHST- 2012/12/21 06:00 [entrez]
PHST- 2012/12/21 06:00 [pubmed]
PHST- 2013/08/01 06:00 [medline]
AID - 10.1111/j.1752-8062.2012.00441.x [doi]
PST - ppublish
SO  - Clin Transl Sci. 2012 Dec;5(6):445-51. doi: 10.1111/j.1752-8062.2012.00441.x.
      Epub 2012 Aug 7.


PMID- 23253554
OWN - NLM
STAT- MEDLINE
DCOM- 20130613
LR  - 20220409
IS  - 1756-0500 (Electronic)
IS  - 1756-0500 (Linking)
VI  - 5
IP  - 1
DP  - 2012 Dec 19
TI  - Measles outbreak investigation in Zaka, Masvingo Province, Zimbabwe, 2010.
PG  - 687
LID - 10.1186/1756-0500-5-687 [doi]
AB  - BACKGROUND: A measles outbreak was detected at Ndanga Hospital in Zaka district
      Masvingo Province on the 5th of May 2010 and there were five deaths. Source of
      infection was not known and an investigation was carried out to determine factors
      associated with contracting measles in Zaka district. MATERIALS AND METHODS: A
      1:1 unmatched case control study was conducted. A case was a person residing in
      Zaka district who developed signs and symptoms of measles or tested IgM positive 
      from 06 May 2010 to 30 August 2010. A control was a person residing in the same
      community who did not have history of signs and symptoms of measles during the
      same period. A structured interviewer administered questionnaire (translated into
      shona) was used to solicit information from cases and controls. Ethical
      consideration like written consent from all participants, respect and
      confidentiality were observed. Permission to carry out the study was obtained
      from the medical research Council of Zimbabwe and the provincial Medical
      Directors Masvingo. Epi info was used to calculate frequencies, odds ratios and
      perform logistic regression to control for confounding variables. FINDINGS: A
      total of 110 cases and 110 controls were recruited. Most cases (63.03%) were from
      the apostolic sect while 44.7% of controls were from orthodox churches. Contact
      with a measles case [AOR= 41.14, 95% CI (7.47-226.5)],being unvaccinated against 
      measles [AOR= 3.96, 95%CI (2.58-6.08)] and not receiving additional doses of
      measles vaccine [AOR 5.48, 95% CI (2.16-11.08)] were independent risk factor for 
      contracting measles. Measles vaccination coverage for Zaka district was 75%. The 
      median duration for seeking treatment after onset of illness was three days
      (Q1=2; Q3=7). There were no emergency preparedness plans in place. CONCLUSION:
      This outbreak occurred due to a large number of unvaccinated children and a
      boarding school that facilitated person to person transmission. We recommend
      mandatory vaccination for all children before enrolling into schools. As a result
      of the study one day training on outbreak management and surveillance was done
      with all District Nursing Officers and Environmental Health Officers in personnel
      in the province.
FAU - Pomerai, Kufakwanguzvarova W
AU  - Pomerai KW
AD  - Department of Community Medicine, University of Zimbabwe, P. O. Box A178, Harare,
      Zimbabwe. pomeraiwilbert1@gmail.com
FAU - Mudyiradima, Robert F
AU  - Mudyiradima RF
FAU - Gombe, Notion T
AU  - Gombe NT
LA  - eng
PT  - Journal Article
DEP - 20121219
PL  - England
TA  - BMC Res Notes
JT  - BMC research notes
JID - 101462768
RN  - 0 (Measles Vaccine)
SB  - IM
MH  - Adolescent
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - *Disease Outbreaks
MH  - Female
MH  - Humans
MH  - Male
MH  - Measles/*epidemiology/immunology/prevention & control
MH  - Measles Vaccine/administration & dosage/immunology
MH  - Measles virus/immunology/*isolation & purification
MH  - Risk Factors
MH  - Surveys and Questionnaires
MH  - Young Adult
MH  - Zimbabwe/epidemiology
PMC - PMC3541261
EDAT- 2012/12/21 06:00
MHDA- 2013/06/14 06:00
CRDT- 2012/12/21 06:00
PHST- 2012/01/23 00:00 [received]
PHST- 2012/11/07 00:00 [accepted]
PHST- 2012/12/21 06:00 [entrez]
PHST- 2012/12/21 06:00 [pubmed]
PHST- 2013/06/14 06:00 [medline]
AID - 1756-0500-5-687 [pii]
AID - 10.1186/1756-0500-5-687 [doi]
PST - epublish
SO  - BMC Res Notes. 2012 Dec 19;5(1):687. doi: 10.1186/1756-0500-5-687.


PMID- 23252318
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20191027
IS  - 0037-8046 (Print)
IS  - 0037-8046 (Linking)
VI  - 57
IP  - 3
DP  - 2012 Jul
TI  - The ethic of care: recapturing social work's first voice.
PG  - 271-80
AB  - This article examines the dynamic between expressions of care--that is, simple
      acts of kindness and consideration that make up friendly relations--and
      professional expertise. During the 20th century, social work based its expertise 
      on a solid scientific foundation. Within the embrace of scientific expertise,
      expressions of care are assigned the vital, but limited, role of ameliorating the
      sterile application of scientific knowledge, mainly through the application of
      social work values. This role is limited, however, because social workers are
      cautioned to avoid dual relationships; one cannot be both a professional and a
      friend to the client. This was not always the case. Working from a different
      paradigm, Charity Organization Society workers and settlement house workers each 
      actively embraced and nurtured the notion of being a friend and neighbor to those
      they served. Post-modern practices--also stemming from a different paradigm and
      embracing an expertise in critical consciousness, in turn--seek to redefine the
      client-social worker relationship along this dimension. Expressions of care,
      propagated through a genuine (albeit circumscribed) friendship, actively
      contribute to treatment planning and a more fruitful outcome.
FAU - Dybicz, Phillip
AU  - Dybicz P
AD  - School of Social Work, Keimyung University, Dalseo-Gu, Daegu, South Korea.
      pdybicz@gmail.com
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Soc Work
JT  - Social work
JID - 2984852R
SB  - IM
MH  - *Ethics, Professional
MH  - Humans
MH  - Professional-Patient Relations/*ethics
MH  - Social Work/*ethics
EDAT- 2012/12/21 06:00
MHDA- 2013/02/13 06:00
CRDT- 2012/12/21 06:00
PHST- 2012/12/21 06:00 [entrez]
PHST- 2012/12/21 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
AID - 10.1093/sw/sws007 [doi]
PST - ppublish
SO  - Soc Work. 2012 Jul;57(3):271-80. doi: 10.1093/sw/sws007.


PMID- 23252316
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20191027
IS  - 0037-8046 (Print)
IS  - 0037-8046 (Linking)
VI  - 57
IP  - 3
DP  - 2012 Jul
TI  - Social work practice in the digital age: therapeutic e-mail as a direct practice 
      methodology.
PG  - 249-58
AB  - The author addresses the risks and benefits of incorporating therapeutic e-mail
      communication into clinical social work practice. Consumer demand for online
      clinical services is growing faster than the professional response. E-mail, when 
      used as an adjunct to traditional meetings with clients, offers distinct
      advantages and risks. Benefits include the potential to reach clients in
      geographically remote and underserved communities, enhancing and extending the
      therapeutic relationship and improving treatment outcomes. Risks include threats 
      to client confidentiality and privacy, liability coverage for practitioners,
      licensing jurisdiction, and the lack of competency standards for delivering
      e-mail interventions. Currently, the social work profession does not have
      adequate instructive guidelines and best-practice standards for using e-mail as a
      direct practice methodology. Practitioners need (formal) academic training in the
      techniques connected to e-mail exchanges with clients. The author describes the
      ethical and legal risks for practitioners using therapeutic e-mail with clients
      and identifies recommendations for establishing best-practice standards.
FAU - Mattison, Marian
AU  - Mattison M
AD  - Department of Social Work, Providence College, Providence, RI 02918, USA.
      mmattisn@providence.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Soc Work
JT  - Social work
JID - 2984852R
SB  - IM
MH  - Confidentiality/ethics/legislation & jurisprudence
MH  - *Electronic Mail/ethics/legislation & jurisprudence
MH  - Ethics, Professional
MH  - Humans
MH  - Privacy/legislation & jurisprudence
MH  - *Professional-Patient Relations/ethics
MH  - Social Work/ethics/legislation & jurisprudence/*trends
EDAT- 2012/12/21 06:00
MHDA- 2013/02/13 06:00
CRDT- 2012/12/21 06:00
PHST- 2012/12/21 06:00 [entrez]
PHST- 2012/12/21 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
AID - 10.1093/sw/sws021 [doi]
PST - ppublish
SO  - Soc Work. 2012 Jul;57(3):249-58. doi: 10.1093/sw/sws021.


PMID- 23252208
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20220311
IS  - 0125-2208 (Print)
IS  - 0125-2208 (Linking)
VI  - 95
IP  - 11
DP  - 2012 Nov
TI  - Single injection fascia iliaca block for pain control after arthroscopic anterior
      cruciate ligament reconstruction: a randomized, controlled trial.
PG  - 1418-24
AB  - BACKGROUND: Arthroscopic anterior cruciate ligament reconstruction (AACLR) is one
      of the orthopedic surgeries associated with moderate to severe post-operative
      pain. The fascia iliaca block (FIB), a block of the femoral nerve and
      lateralfemoral cutaneous nerve of the thigh, is relatively simple, safe, and
      provides effective analgesia post-operatively OBJECTIVE: To investigate the
      effectiveness of using fascia iliaca block for post-operative pain relief after
      AACLR. MATERIAL AND METHOD: After approval by the Ethics Committee for Khon Kaen 
      University (HE510817), the patients were randomly allocated into two groups using
      a computer-generated random number and concealed by sealed opaque envelopes. FIB 
      was delivered via a 16-gauge Tuohy needle at the PACU. The patients received
      either 0.2 % bupivacaine with adrenaline or 0.9% NSS 40 mL. Morphine consumption,
      time to first rescue analgesia, Numerical Rating Scale (NRS), side effects, and
      complication within 24 hours were recorded RESULTS: Forty-seven patients were
      enrolled. There was a statistically significant difference in the 24 hours
      morphine consumption between the bupivacaine and NSS groups (22.1 +/- 7.2 and
      31.8 +/- 9.3 mg, respectively; p < 0.001). Time to first rescue analgesia was
      significantly longer in the bupivacaine group (4.60 +/- 2.2 vs. 2.83 +/- 1.6 hour
      p 0.003). The difference of resting and on movement pain score were also
      significant (2.1 (95% CI 1.3-2.8), p < 0.001 and 1.8 (95% CI 1.2-2.4), p < 0.001 
      respectively. Neither serious side effect nor neurological sequel was found.
      CONCLUSION: The fascia iliaca block is effective for providing pain control for
      at least 24 hours after anterior cruciate ligament reconstruction. This technique
      is quite easy, safe, and inexpensive to use.
FAU - Wongswadiwat, Malinee
AU  - Wongswadiwat M
AD  - Department of Anesthesiology, Faculty of Medicine, Khon Kaen University, Khon
      Kaen, Thailand. wmalin@kku.ac.th
FAU - Pathanon, Panatda
AU  - Pathanon P
FAU - Sriraj, Wimonrat
AU  - Sriraj W
FAU - Yimyaem, Panaratana Ratanasuwan
AU  - Yimyaem PR
FAU - Bunthaothuk, Sudjai
AU  - Bunthaothuk S
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Thailand
TA  - J Med Assoc Thai
JT  - Journal of the Medical Association of Thailand = Chotmaihet thangphaet
JID - 7507216
RN  - 0 (Analgesics, Opioid)
RN  - 76I7G6D29C (Morphine)
SB  - IM
MH  - Adult
MH  - Analgesics, Opioid/administration & dosage
MH  - *Anterior Cruciate Ligament Reconstruction
MH  - Arthroscopy/*methods
MH  - Fascia
MH  - Female
MH  - Femoral Nerve
MH  - Humans
MH  - Male
MH  - Morphine/administration & dosage
MH  - Nerve Block/*methods
MH  - Pain Management
MH  - Pain Measurement
MH  - Pain, Postoperative/*prevention & control
MH  - Treatment Outcome
EDAT- 2012/12/21 06:00
MHDA- 2013/02/13 06:00
CRDT- 2012/12/21 06:00
PHST- 2012/12/21 06:00 [entrez]
PHST- 2012/12/21 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
PST - ppublish
SO  - J Med Assoc Thai. 2012 Nov;95(11):1418-24.


PMID- 23252063
OWN - NLM
STAT- MEDLINE
DCOM- 20130103
LR  - 20121220
IS  - 1461-3123 (Print)
IS  - 1461-3123 (Linking)
VI  - 15
IP  - 9
DP  - 2012 Oct
TI  - Public asked about ethics of creating three-parent babies to prevent disease.
PG  - 6
LA  - eng
PT  - News
PL  - England
TA  - Pract Midwife
JT  - The practising midwife
JID - 9814758
MH  - Female
MH  - Fertilization in Vitro/*ethics
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - Mitochondria/*transplantation
MH  - Mitochondrial Diseases/nursing/*prevention & control
MH  - Spermatozoa
EDAT- 2012/12/21 06:00
MHDA- 2013/01/04 06:00
CRDT- 2012/12/21 06:00
PHST- 2012/12/21 06:00 [entrez]
PHST- 2012/12/21 06:00 [pubmed]
PHST- 2013/01/04 06:00 [medline]
PST - ppublish
SO  - Pract Midwife. 2012 Oct;15(9):6.


PMID- 23251123
OWN - NLM
STAT- MEDLINE
DCOM- 20130604
LR  - 20220629
IS  - 1552-5775 (Electronic)
IS  - 1552-5767 (Linking)
VI  - 16
IP  - 4
DP  - 2012 Fall
TI  - A model for humanization in critical care.
PG  - 75-7
AB  - We present a case in which narrative medicine was used to assist a patient with
      amyotrophic lateral sclerosis who was dependent on mechanical ventilation and
      prolonged hospitalization. Implementing narrative medicine led to the development
      of more effective communication that strengthened the therapeutic relationship,
      enhanced humane care practices, and resulted in greater physical and
      psychological comfort for the patient. Narrative medicine is a discipline that
      has been progressively incorporated into medical training to restore a humane and
      individual physician-patient relationship. The patient is viewed, not merely as a
      case to diagnose, but as a person with a story that evokes emotions in those who 
      assist him or her. In fact, narrative medicine can be understood as a model of
      medical practice based on narrative competence, ie, the ability to acknowledge,
      to absorb, to interpret, and to respond to a person's story. It strengthens
      empathy, rescues patient individuality, and facilitates solutions to conflicts in
      complex settings, such as critical care units, where clinicians are constantly
      exposed to existential issues, both moral and ethical.
FAU - Facioli, Adriano Machado
AU  - Facioli AM
AD  - Department of Research and Scientific Communication in Brasilia, DF, Brazil.
      facioli@gmail.com
FAU - Amorim, Fabio Ferreira
AU  - Amorim FF
FAU - de Almeida, Karlo Jozefo Quadros
AU  - de Almeida KJ
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Perm J
JT  - The Permanente journal
JID - 9800474
SB  - IM
MH  - Amyotrophic Lateral Sclerosis/*physiopathology
MH  - Critical Care/*methods
MH  - Hospitalization
MH  - *Humanism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Narration
MH  - *Nonverbal Communication
MH  - *Physician-Patient Relations
MH  - Respiration, Artificial
MH  - Tracheotomy
PMC - PMC3523941
EDAT- 2012/12/20 06:00
MHDA- 2013/06/05 06:00
CRDT- 2012/12/20 06:00
PHST- 2012/12/20 06:00 [entrez]
PHST- 2012/12/20 06:00 [pubmed]
PHST- 2013/06/05 06:00 [medline]
AID - 10.7812/TPP/12-044 [doi]
PST - ppublish
SO  - Perm J. 2012 Fall;16(4):75-7. doi: 10.7812/TPP/12-044.


PMID- 23251116
OWN - NLM
STAT- MEDLINE
DCOM- 20130604
LR  - 20220629
IS  - 1552-5775 (Electronic)
IS  - 1552-5767 (Linking)
VI  - 16
IP  - 4
DP  - 2012 Fall
TI  - Navigating ethics of physician-patient confidentiality: a communication privacy
      management analysis.
PG  - 41-5
AB  - The ethics of physician-patient confidentiality is often fraught with
      contradictions. Privacy boundaries are not always clear, and patients can leave
      an interaction with their physicians feeling uncomfortable about the security of 
      their private medical information. The best way to meet confidentiality and
      privacy management expectations that patients have may not be readily apparent.
      Without realizing it, a physician may communicate a patient's information in ways
      that are inconsistent with that person's perceptions of how his/her medical
      information should be treated. A proposed model is presented as a tool for
      physicians to better serve the privacy and confidentiality needs of their
      patients. This model depends on the communication privacy management (CPM)
      perspective that emerged from a 35-year research program investigating how people
      regulate and control information they consider private and confidential. A
      physician's use of this model enables the ability to establish a confidentiality 
      pledge that can address issues in understanding the best way to communicate about
      privacy management with patients and more likely overcome potential negative
      outcomes.
FAU - Petronio, Sandra
AU  - Petronio S
AD  - Department of Communication Studies, Indiana University School of Liberal Arts,
      Indiana University-Purdue University Indianapolis and Indiana University School
      of Medicine, Indianapolis, Indiana, USA. petronio@iupui.edu
FAU - Dicorcia, Mark J
AU  - Dicorcia MJ
FAU - Duggan, Ashley
AU  - Duggan A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Perm J
JT  - The Permanente journal
JID - 9800474
SB  - IM
MH  - Confidentiality/*ethics
MH  - Disclosure/ethics
MH  - Ethics, Medical
MH  - Humans
MH  - *Models, Organizational
MH  - Physician-Patient Relations/*ethics
MH  - Physicians/ethics
PMC - PMC3523934
EDAT- 2012/12/20 06:00
MHDA- 2013/06/05 06:00
CRDT- 2012/12/20 06:00
PHST- 2012/12/20 06:00 [entrez]
PHST- 2012/12/20 06:00 [pubmed]
PHST- 2013/06/05 06:00 [medline]
AID - 10.7812/TPP/12-042 [doi]
PST - ppublish
SO  - Perm J. 2012 Fall;16(4):41-5. doi: 10.7812/TPP/12-042.


PMID- 23250320
OWN - NLM
STAT- MEDLINE
DCOM- 20131206
LR  - 20191112
IS  - 0124-0064 (Print)
IS  - 0124-0064 (Linking)
VI  - 14
IP  - 1
DP  - 2012 Jan-Feb
TI  - [Terminally-ill patients' end of life problems and related decisions].
PG  - 116-28
LID - S0124-00642012000100010 [pii]
AB  - OBJECTIVES: Describing terminally-ill patients and their relatives' preferences
      regarding end of life decisions, the underlying problems and reasons leading to
      them requesting support. METHODS: This was a descriptive, exploratory analysis of
      the secondary sources in an NGO providing support for patients at the end of
      their lives. RESULTS: The most frequent choice was dying with dignity (43 %),
      followed by euthanasia (12 %). Some people asked for guidance on legal and
      ethical aspects regarding appropriate care for the terminally-ill. The
      pathologies accounting for 75 % of the diagnoses were chronic degenerative
      diseases, cancer and coma. The worsening of symptoms was the main reason for
      requesting support and uncontrollable pain more often led to the choice of
      euthanasia. Only 14 % of the patients had formalised their wills regarding their 
      end of life decisions. The choice of dying with dignity was related to rejecting 
      futile measures and therapeutic cruelty. Euthanasia was seen as an autonomous
      intentional action to end suffering. The family plays an essential role in making
      end of life decisions. CONCLUSIONS: End of life decisions are motivated by a
      perception of undignified conditions for patients due to progressive
      deterioration, poorly controlled pain, abandoning of chronic patients,
      therapeutic obstinacy and unnecessary measures that postpone death. They are
      taken within a complex context concerning religious dilemmas and ethical or legal
      concerns.
FAU - Sarmiento-Medina, Maria I
AU  - Sarmiento-Medina MI
AD  - Universidad El Bosque, Bogota, Colombia. sarmientomaria@unbosque.edu.co
FAU - Vargas-Cruz, Sandra L
AU  - Vargas-Cruz SL
FAU - Velasquez-Jimenez, Claudia M
AU  - Velasquez-Jimenez CM
FAU - Sierra de Jaramillo, Margarita
AU  - Sierra de Jaramillo M
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Problemas y decisiones al final de la vida en pacientes con enfermedad en etapa
      terminal.
PL  - Colombia
TA  - Rev Salud Publica (Bogota)
JT  - Revista de salud publica (Bogota, Colombia)
JID - 100936348
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Advance Directives/statistics & numerical data
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - Child, Preschool
MH  - Colombia
MH  - *Decision Making
MH  - Family Relations
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Middle Aged
MH  - Patient Preference/*statistics & numerical data
MH  - Right to Die
MH  - Terminal Care/methods/*psychology
MH  - Terminally Ill/*psychology
MH  - Treatment Refusal/psychology
MH  - Young Adult
EDAT- 2012/12/20 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/12/20 06:00
PHST- 2011/03/14 00:00 [received]
PHST- 2012/01/31 00:00 [accepted]
PHST- 2012/12/20 06:00 [entrez]
PHST- 2012/12/20 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - S0124-00642012000100010 [pii]
AID - 10.1590/s0124-00642012000100010 [doi]
PST - ppublish
SO  - Rev Salud Publica (Bogota). 2012 Jan-Feb;14(1):116-28. doi:
      10.1590/s0124-00642012000100010.


PMID- 23250229
OWN - NLM
STAT- MEDLINE
DCOM- 20130325
LR  - 20211021
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 2
DP  - 2013 Feb
TI  - Reporting of patient consent in healthcare cluster randomised trials is
      associated with the type of study interventions and publication characteristics.
PG  - 119-24
LID - 10.1136/medethics-2012-100746 [doi]
AB  - OBJECTIVE: Cluster randomised trial (CRT) investigators face challenges in
      seeking informed consent from individual patients (cluster members). This study
      examined associations between reporting of patient consent in healthcare CRTs and
      characteristics of these trials. STUDY DESIGN: Consent practices and study
      characteristics were abstracted from a random sample of 160 CRTs performed in
      primary or hospital care settings that were published from 2000 to 2008.
      Multivariable logistic regression was used to examine associations between
      reporting of patient consent and methodological characteristics, as well as
      publication features such as date and journal of publication. RESULTS: 82 (53.8%)
      of 160 studies reported obtaining informed consent from individual patients.
      Reporting of patient consent was independently and positively associated with:
      smaller cluster size, the evaluation of experimental interventions targeted at
      patients, data collection from individual patients, publication later than 2004
      and publication in higher-impact journals. CONCLUSIONS: Reporting of consent
      practices in published CRTs should be improved. Consent practices in published
      CRTs appear to be related to the type of interventions under study, as well as
      journal impact and trends in research ethics practices. These findings will
      inform best practices in trial conduct and ethics review, remediation of errors
      in consent practices and ethics review and the development of regulatory guidance
      for CRTs.
FAU - McRae, Andrew
AU  - McRae A
AD  - Department of Emergency Medicine, University of Calgary, Calgary, Alberta,
      Canada. Andrew.McRae@albertahealthservices.ca
FAU - Taljaard, Monica
AU  - Taljaard M
FAU - Weijer, Charles
AU  - Weijer C
FAU - Bennett, Carol
AU  - Bennett C
FAU - Skea, Zoe
AU  - Skea Z
FAU - Boruch, Robert
AU  - Boruch R
FAU - Brehaut, Jamie
AU  - Brehaut J
FAU - Eccles, Martin
AU  - Eccles M
FAU - Grimshaw, Jeremy
AU  - Grimshaw J
FAU - Donner, Allan
AU  - Donner A
LA  - eng
GR  - HSRU2/CSO_/Chief Scientist Office/United Kingdom
GR  - MOP85066/CAPMC/ CIHR/Canada
GR  - MOP89790/CAPMC/ CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121218
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Ethics, Research
MH  - Health Services Research/*ethics/methods
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Journal Impact Factor
MH  - Logistic Models
MH  - Multivariate Analysis
MH  - Odds Ratio
MH  - Periodicals as Topic
MH  - Publishing
MH  - Randomized Controlled Trials as Topic/*ethics/methods
MH  - *Research Design
MH  - *Research Report
EDAT- 2012/12/20 06:00
MHDA- 2013/03/26 06:00
CRDT- 2012/12/20 06:00
PHST- 2012/12/20 06:00 [entrez]
PHST- 2012/12/20 06:00 [pubmed]
PHST- 2013/03/26 06:00 [medline]
AID - medethics-2012-100746 [pii]
AID - 10.1136/medethics-2012-100746 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Feb;39(2):119-24. doi: 10.1136/medethics-2012-100746. Epub
      2012 Dec 18.


PMID- 23250187
OWN - NLM
STAT- MEDLINE
DCOM- 20130524
LR  - 20121219
IS  - 1526-3711 (Electronic)
IS  - 1526-3711 (Linking)
VI  - 13
IP  - 5
DP  - 2012 Sep 1
TI  - Ethical acumen: the dexterity to balance clinical care, research and publication.
PG  - i
FAU - Patil, Shankargouda
AU  - Patil S
LA  - eng
PT  - Editorial
DEP - 20120901
PL  - India
TA  - J Contemp Dent Pract
JT  - The journal of contemporary dental practice
JID - 101090552
SB  - IM
MH  - Dental Care/*ethics
MH  - Dental Research/*ethics
MH  - *Ethics, Dental
MH  - Helsinki Declaration
MH  - Humans
MH  - Publishing/*ethics
EDAT- 2012/12/20 06:00
MHDA- 2013/05/28 06:00
CRDT- 2012/12/20 06:00
PHST- 2012/12/20 06:00 [entrez]
PHST- 2012/12/20 06:00 [pubmed]
PHST- 2013/05/28 06:00 [medline]
AID - 1526-3711-925 [pii]
PST - epublish
SO  - J Contemp Dent Pract. 2012 Sep 1;13(5):i.


PMID- 23250096
OWN - NLM
STAT- MEDLINE
DCOM- 20130731
LR  - 20160815
IS  - 1806-9282 (Electronic)
IS  - 0104-4230 (Linking)
VI  - 58
IP  - 6
DP  - 2012 Nov-Dec
TI  - Prevalence and factors associated with thoracic alterations in infants born
      prematurely.
PG  - 679-84
LID - S0104-42302012000600012 [pii]
AB  - OBJECTIVE: To determine the prevalence of thoracic musculoskeletal alterations
      and associated factors in infants born prematurely. METHODS: This was a cross
      sectional study with infants in the first year of age, born prematurely with
      birth weight < 2,000 g, who were followed up at the Premature Clinic from
      February, 2007 to December, 2008. Exclusion criteria were: major congenital
      malformations as defined by the Centers for Disease Control and Prevention (CDC),
      grade III/IV intraventricular hemorrhage, or periventricular leucomalacia.
      Physical examinations performed independently by two physiotherapists were used
      to assess shoulder elevation and thoracic retractions. Comparisons between groups
      were performed using the chi-squared test or Fisher's exact test for categorical 
      variables, and Mann-Whitney's test or Student's t-test were used for continuous
      variables. Interobserver reliability between the two physiotherapists was
      assessed by the kappa coefficient. Variables associated with these thoracic
      musculoskeletal alterations were studied by univariate and multiple logistic
      analyses. Statistical differences were considered significant when p < 0.05. This
      study was approved by the ethical committee of the institution, and
      parents/guardians signed an informed consent. RESULTS: 121 infants with a
      gestational age of 31.1 +/- 2.8 weeks and birth weight of 1,400 +/- 338 g were
      included. Thoracic alterations were detected by Physiotherapist 1 in 81 (66.9%)
      infants, and in 83 (68.6%) by Physiotherapist 2 (kappa coefficient = 0.77). By
      multivariate logistic regression analysis, factors associated with thoracic
      musculoskeletal alterations were: respiratory distress syndrome (odds ratio [OR] 
      = 3.246, 95% confidence interval [CI]: 1.237-8.732), bronchopulmonary dysplasia
      (OR = 11.138, 95% CI: 1.339-92.621), and low length/age ratio (OR = 4.571, 95%
      CI: 1.371-15.242). CONCLUSION: The prevalence of thoracic alterations was high in
      infants born prematurely, and was associated with pulmonary disease and low
      length/age ratio.
FAU - Davidson, Josy
AU  - Davidson J
AD  - Neonatal Division of Medicine, Department of Pediatrics, Universidade Federal de 
      Sao Paulo, Sao Paulo, SP, Brazil.
FAU - Garcia, Kessey Maria B
AU  - Garcia KM
FAU - Yi, Liu C
AU  - Yi LC
FAU - Goulart, Ana Lucia
AU  - Goulart AL
FAU - Santos, Amelia Miyashiro N dos
AU  - Santos AM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Brazil
TA  - Rev Assoc Med Bras (1992)
JT  - Revista da Associacao Medica Brasileira (1992)
JID - 9308586
SB  - IM
MH  - Birth Weight
MH  - Brazil/epidemiology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Gestational Age
MH  - Humans
MH  - Infant, Newborn
MH  - *Infant, Premature
MH  - Male
MH  - Musculoskeletal Abnormalities/complications/*epidemiology/rehabilitation
MH  - Physical Therapy Modalities
MH  - Posture
MH  - Prevalence
MH  - Thorax/*abnormalities
EDAT- 2012/12/20 06:00
MHDA- 2013/08/01 06:00
CRDT- 2012/12/20 06:00
PHST- 2011/01/12 00:00 [received]
PHST- 2012/10/07 00:00 [accepted]
PHST- 2012/12/20 06:00 [entrez]
PHST- 2012/12/20 06:00 [pubmed]
PHST- 2013/08/01 06:00 [medline]
AID - S0104-42302012000600012 [pii]
PST - ppublish
SO  - Rev Assoc Med Bras (1992). 2012 Nov-Dec;58(6):679-84.


PMID- 23250025
OWN - NLM
STAT- MEDLINE
DCOM- 20151123
LR  - 20121219
IS  - 2115-7863 (Electronic)
IS  - 2115-7863 (Linking)
VI  - 10
IP  - 4
DP  - 2012 Dec
TI  - [Ethics and neuropsychological assessment].
PG  - 445-52
LID - 10.1684/pnv.2012.0372 [doi]
AB  - Ethics and its relation to testing are historically an important question and
      still are. In this article, we briefly report on how neuropsychology emerged as a
      specific field, how tests are developed and we particularly focus on the ethical 
      conditions under which a test can be administered. The point of view of the
      neuropsychologist who develops a new test, of the neuropsychologist who uses this
      test, of the person requiring a neuropsychological assessment, and finally of the
      subject, are respectively taken. In each case, different ethical questions are
      raised. Illustrations and examples are provided. A misunderstanding of what a
      test really is (a given and precise experimental situation) leads to many
      difficulties. Furthermore, many fail to know that neuropsychological assessment
      requires specific skills and clinical practice. A test is not related to truth or
      to a verdict; it only allows classifying a performance with regard to a given
      norm.
FAU - Thomas-Anterion, Catherine
AU  - Thomas-Anterion C
AD  - Laboratoire etude mecanismes cognitifs, EA3082, Universite Lumiere Lyon 2,
      France.
FAU - Barbeau, Emmanuel
AU  - Barbeau E
LA  - fre
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Ethique et tests neuropsychologiques.
PL  - France
TA  - Geriatr Psychol Neuropsychiatr Vieil
JT  - Geriatrie et psychologie neuropsychiatrie du vieillissement
JID - 101553404
SB  - IM
MH  - Aged
MH  - Alzheimer Disease/*diagnosis/*psychology
MH  - Clinical Competence
MH  - Comprehension
MH  - Cooperative Behavior
MH  - Diagnosis, Differential
MH  - *Ethics, Medical
MH  - Female
MH  - Humans
MH  - Interdisciplinary Communication
MH  - Male
MH  - Middle Aged
MH  - *Neuropsychological Tests/statistics & numerical data
MH  - Patient Education as Topic/ethics
MH  - Psychometrics/statistics & numerical data
MH  - Reference Values
MH  - Reproducibility of Results
EDAT- 2012/12/20 06:00
MHDA- 2015/12/15 06:00
CRDT- 2012/12/20 06:00
PHST- 2012/12/20 06:00 [entrez]
PHST- 2012/12/20 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - pnv.2012.0372 [pii]
AID - 10.1684/pnv.2012.0372 [doi]
PST - ppublish
SO  - Geriatr Psychol Neuropsychiatr Vieil. 2012 Dec;10(4):445-52. doi:
      10.1684/pnv.2012.0372.


PMID- 23249685
OWN - NLM
STAT- MEDLINE
DCOM- 20130401
LR  - 20211021
IS  - 1476-1645 (Electronic)
IS  - 0002-9637 (Linking)
VI  - 88
IP  - 2
DP  - 2013 Feb
TI  - Incidence of malaria among mosquito collectors conducting human landing catches
      in western Kenya.
PG  - 301-8
LID - 10.4269/ajtmh.2012.12-0209 [doi]
AB  - The human landing catch (HLC) has long been the gold standard for estimating
      malaria transmission by mosquitoes, but has come under scrutiny because of
      ethical concerns of exposing collectors to infectious bites. We estimated the
      incidence of Plasmodium falciparum malaria infection in a cohort of 152 persons
      conducting HLCs and compared it with that of 147 non-collectors in western Kenya.
      Participants were presumptively cleared of malaria with Coartem
      (artemether-lumefantrine) and tested for malaria every 2 weeks for 12 weeks. The 
      HLC collections were conducted four nights per week for six weeks. Collectors
      were provided chemoprophylaxis with Malarone (atovaquone-proguanil) during the
      six weeks of HLC activities and one week after HLC activities were completed. The
      incidence of malaria was 96.6% lower in collectors than in non-collectors (hazard
      ratio = 0.034, P < 0.0001). Therefore, with proper prophylaxis, concern about
      increased risk of malaria among collectors should not be an impediment to
      conducting HLC studies.
FAU - Gimnig, John E
AU  - Gimnig JE
AD  - Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for
      Disease Control and Prevention, Atlanta, GA 30329, USA. jgimnig@cdc.gov
FAU - Walker, Edward D
AU  - Walker ED
FAU - Otieno, Peter
AU  - Otieno P
FAU - Kosgei, Jackline
AU  - Kosgei J
FAU - Olang, George
AU  - Olang G
FAU - Ombok, Maurice
AU  - Ombok M
FAU - Williamson, John
AU  - Williamson J
FAU - Marwanga, Doris
AU  - Marwanga D
FAU - Abong'o, Daisy
AU  - Abong'o D
FAU - Desai, Meghna
AU  - Desai M
FAU - Kariuki, Simon
AU  - Kariuki S
FAU - Hamel, Mary J
AU  - Hamel MJ
FAU - Lobo, Neil F
AU  - Lobo NF
FAU - Vulule, John
AU  - Vulule J
FAU - Bayoh, M Nabie
AU  - Bayoh MN
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20121218
PL  - United States
TA  - Am J Trop Med Hyg
JT  - The American journal of tropical medicine and hygiene
JID - 0370507
RN  - 0 (Drug Combinations)
RN  - 0 (atovaquone, proguanil drug combination)
RN  - S61K3P7B2V (Proguanil)
RN  - Y883P1Z2LT (Atovaquone)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Atovaquone/therapeutic use
MH  - Cohort Studies
MH  - Drug Combinations
MH  - Humans
MH  - Incidence
MH  - Kenya/epidemiology
MH  - Logistic Models
MH  - Malaria, Falciparum/*epidemiology/*prevention & control
MH  - Male
MH  - Middle Aged
MH  - Proguanil/therapeutic use
MH  - Prospective Studies
MH  - Risk Factors
MH  - Surveys and Questionnaires
MH  - Young Adult
PMC - PMC3583321
EDAT- 2012/12/20 06:00
MHDA- 2013/04/02 06:00
CRDT- 2012/12/20 06:00
PHST- 2012/12/20 06:00 [entrez]
PHST- 2012/12/20 06:00 [pubmed]
PHST- 2013/04/02 06:00 [medline]
AID - ajtmh.2012.12-0209 [pii]
AID - 10.4269/ajtmh.2012.12-0209 [doi]
PST - ppublish
SO  - Am J Trop Med Hyg. 2013 Feb;88(2):301-8. doi: 10.4269/ajtmh.2012.12-0209. Epub
      2012 Dec 18.


PMID- 23249668
OWN - NLM
STAT- MEDLINE
DCOM- 20130211
LR  - 20211021
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 345
DP  - 2012 Dec 18
TI  - Placebos in 19th century medicine: a quantitative analysis of the BMJ.
PG  - e8326
LID - 10.1136/bmj.e8326 [doi]
LID - bmj.e8326 [pii]
AB  - OBJECTIVE: To provide the first quantitative data on the use of the term
      "placebo" in the 19th century. DESIGN: Computer search of BMJ's archival database
      from January 1840 (the first issue) through December 1899 for uses of the words
      "placebo(s)." Grounded theory was used to categorise the implications of uses of 
      the term. RESULTS: 71 citations contained the term "placebo(s)." Of these, 22
      (31%) used the term to mean "no effect" or as a general pejorative term, 18 (25%)
      portrayed placebo treatment as permitting the unfolding of the natural history
      (the normal waxing and waning of illness), 14 (20%) described placebo as
      important to satisfy patients, 7 (10%) described it as fulfilling a physician's
      performance role, 3 (4%) described its use to buy time, 3 (4%) described its use 
      for financial gain, 2 (3%) used it in a manner similar to a placebo control, and 
      only one implied that placebo could have a clinical effect. Only one citation
      mentioned telling the patient about his placebo treatment. CONCLUSION: Nineteenth
      century physicians had diverse a priori assumptions about placebos. These
      findings remind us that contemporary medicine needs to use rigorous science to
      separate fact from its own beliefs concerning the "provision of care." As in
      previous generations, ethical issues concerning placebos continue to challenge
      medicine.
FAU - Raicek, Jacqueline E
AU  - Raicek JE
AD  - Program in Placebo Studies and Therapeutic Encounter, Beth Israel Deaconess
      Medical Center, Harvard Medical School, Boston, MA 02215, USA.
FAU - Stone, Bradley H
AU  - Stone BH
FAU - Kaptchuk, Ted J
AU  - Kaptchuk TJ
LA  - eng
GR  - R01 AT004662/AT/NCCIH NIH HHS/United States
GR  - R01 AT006364/AT/NCCIH NIH HHS/United States
GR  - R01AT005280/AT/NCCIH NIH HHS/United States
GR  - P01 AT006663/AT/NCCIH NIH HHS/United States
GR  - K24 AT004095/AT/NCCIH NIH HHS/United States
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20121218
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
RN  - 0 (Placebos)
SB  - IM
MH  - History, 19th Century
MH  - Humans
MH  - Periodicals as Topic/*history
MH  - Placebos/*history
MH  - *Terminology as Topic
PMC - PMC3525309
EDAT- 2012/12/20 06:00
MHDA- 2013/02/12 06:00
CRDT- 2012/12/20 06:00
PHST- 2012/12/20 06:00 [entrez]
PHST- 2012/12/20 06:00 [pubmed]
PHST- 2013/02/12 06:00 [medline]
AID - 10.1136/bmj.e8326 [doi]
PST - epublish
SO  - BMJ. 2012 Dec 18;345:e8326. doi: 10.1136/bmj.e8326.


PMID- 23249569
OWN - NLM
STAT- MEDLINE
DCOM- 20130516
LR  - 20151119
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 267
IP  - 1
DP  - 2013 Apr
TI  - Temporomandibular joints in asymptomatic and symptomatic nonpatient volunteers: a
      prospective 15-year follow-up clinical and MR imaging study.
PG  - 183-94
LID - 10.1148/radiol.12112243 [doi]
AB  - PURPOSE: To determine the incidence, prevalence, and progression of
      temporomandibular joint (TMJ) magnetic resonance (MR) imaging findings and
      symptoms during 15 years in adult asymptomatic and symptomatic volunteers
      (nonpatients). MATERIALS AND METHODS: A regional committee for medical research
      ethics approved the study, and informed volunteer consent was obtained.
      Fifty-three volunteers were examined at study inception. For clinical assessment,
      a self-administered questionnaire was given, followed by an interview with each
      volunteer at study inception, at 1 year later, and at 15 years later. Bilateral
      TMJ MR imaging and clinical examination were performed at inception and at
      15-year follow-up. The MR images were assessed for disk position, bone status,
      and joint fluid. All 53 volunteers participated at 1-year follow-up, and 50 of 53
      volunteers participated at 15-year follow-up; of these 50 volunteers, 47
      underwent MR imaging. The Fisher exact test was used to determine differences
      between groups, and the Wilcoxon signed-rank test was used to determine
      differences in prevalence of TMJ symptoms among the three examination times.
      RESULTS: At study inception, TMJ disk displacement was observed in 31% of
      asymptomatic volunteers (nine of 29) compared with 89% of symptomatic volunteers 
      (16 of 18, P < .001). Inceptive TMJ status was maintained after 15 years in 91%
      (43 of 47). Unilateral progression was observed in four volunteers (9%); one was 
      symptomatic and three were asymptomatic. Progression involved development of new 
      disk displacement (n = 1), development of new bone changes (n = 2), and
      aggravation from reducing to nonreducing disk displacement (n = 1). Prevalence of
      TMJ symptoms did not change significantly between examination times (P = .77).
      TMJ clicking was the most common clinical symptom. CONCLUSION: Volunteers with
      mild symptoms had a prevalence of disk displacement of the same magnitude as that
      reported in patients, although most volunteers, symptomatic as well as
      asymptomatic, maintained their TMJ status during 15 years.
CI  - RSNA, 2012
FAU - Sale, Hanna
AU  - Sale H
AD  - Oral and Maxillofacial Radiology Division, Department of Odontology, Faculty of
      Medicine, Umea University, Umea, Sweden. hanna.sale@mah.se
FAU - Bryndahl, Fredrik
AU  - Bryndahl F
FAU - Isberg, Annika
AU  - Isberg A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121218
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Incidence
MH  - Interviews as Topic
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Prospective Studies
MH  - Statistics, Nonparametric
MH  - Surveys and Questionnaires
MH  - Temporomandibular Joint Disorders/*diagnosis/epidemiology
EDAT- 2012/12/20 06:00
MHDA- 2013/05/17 06:00
CRDT- 2012/12/20 06:00
PHST- 2012/12/20 06:00 [entrez]
PHST- 2012/12/20 06:00 [pubmed]
PHST- 2013/05/17 06:00 [medline]
AID - radiol.12112243 [pii]
AID - 10.1148/radiol.12112243 [doi]
PST - ppublish
SO  - Radiology. 2013 Apr;267(1):183-94. doi: 10.1148/radiol.12112243. Epub 2012 Dec
      18.


PMID- 23248912
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20121219
IS  - 1320-3185 (Print)
IS  - 1320-3185 (Linking)
VI  - 20
IP  - 2
DP  - 2012 Aug
TI  - Workplace ethics and respect for colleagues.
PG  - 31
FAU - Johnstone, Megan-Jane
AU  - Johnstone MJ
AD  - School of Nursing and Midwifery at Deakin University, Victoria.
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Aust Nurs J
JT  - Australian nursing journal (July 1993)
JID - 9317904
MH  - *Ethics, Nursing
MH  - Humans
MH  - Interprofessional Relations/*ethics
MH  - Organizational Policy
MH  - *Workplace
EDAT- 2012/12/20 06:00
MHDA- 2013/02/13 06:00
CRDT- 2012/12/20 06:00
PHST- 2012/12/20 06:00 [entrez]
PHST- 2012/12/20 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
PST - ppublish
SO  - Aust Nurs J. 2012 Aug;20(2):31.


PMID- 23248845
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20170203
IS  - 0723-1393 (Print)
IS  - 0723-1393 (Linking)
VI  - 31
IP  - 3
DP  - 2012 Sep
TI  - The first years of the Finnish Act on Assisted Fertility Treatments--observations
      from the viewpoint of a supervisory authority.
PG  - 473-89
AB  - The Act on Assisted Fertility Treatments (1237/2006) entered into force on 1
      September 2007. Prior to the entry into force of the Act, the provision of
      assisted fertility treatments in Finland was governed by general health care
      legislation and professional ethics codes. The drafting of the Act was a process 
      of exceptional difficulty and duration. With drafting commencing already in the
      early 1980s, Finland was, at the time, at the forefront among Western
      industrialised nations, yet ultimately it became one of the last European nations
      to enact legislation in this sector. The major stumbling blocks in the drafting
      process concerned surrogacy, the right of persons conceived by using donated
      gametes to learn the identity of the donor, and access to assisted fertility
      treatments for single women and lesbian couples. Almost four years of experiences
      have now been accumulated with the Act. From the perspective of the authority
      with oversight of the activities, the National Supervisory Authority for Welfare 
      and Health (Valvira), the Act has proven quite effective. Interpretation of its
      individual provisions has required fine-tuning, as is only natural in the case of
      new legislation. The thorniest issues in terms of numbers of queries have been
      those relating to the donation of gametes and embryos. Overlaps in licensing
      procedure and oversight based on three different Acts have posed challenges to
      fertility clinics and the supervisory authorities alike. The greatest
      dissatisfaction has been expressed towards the transitional provision, the
      interpretation of which has given rise to differing views and the amendment of
      which has been debated also in Parliament. This article examines issues in
      application of the Act of which Valvira has become aware and developments in
      assisted fertility treatment activities since the entry into force of the Act.
FAU - Burrell, Riitta
AU  - Burrell R
AD  - University of Helsinki. riitta.burrell@valvira.fi
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Med Law
JT  - Medicine and law
JID - 8218185
SB  - IM
MH  - Access to Information/legislation & jurisprudence
MH  - Confidentiality/legislation & jurisprudence
MH  - Embryo Disposition/legislation & jurisprudence
MH  - Female
MH  - Finland
MH  - Humans
MH  - Oocyte Donation/legislation & jurisprudence
MH  - Reproductive Techniques, Assisted/*legislation & jurisprudence
EDAT- 2012/12/20 06:00
MHDA- 2013/03/13 06:00
CRDT- 2012/12/20 06:00
PHST- 2012/12/20 06:00 [entrez]
PHST- 2012/12/20 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
PST - ppublish
SO  - Med Law. 2012 Sep;31(3):473-89.


PMID- 23248843
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20170203
IS  - 0723-1393 (Print)
IS  - 0723-1393 (Linking)
VI  - 31
IP  - 3
DP  - 2012 Sep
TI  - Brain death: the challenges of translating medical science into Islamic
      bioethical discourse.
PG  - 433-50
AB  - Islamic ethico-legal assessments of brain death are varied and controversial.
      Some Islamic ethico-legal bodies have concluded that brain death is equivalent to
      cardiopulmonary death; others regard it as an intermediate state between life and
      death, and a few opine that it does not meet the standards for legal death
      according to Islamic law. Yet this translation of the concept of brain death into
      the Islamic ethico-legal domain has generated multiple ethical complexities that 
      receive insufficient attention within the extant medical and fiqh literature. How
      do Islamic legists understand brain death as a clinical phenomenon? How does the 
      Islamic ethico-legal system treat medical uncertainty? What Islamic ethico-legal 
      principles should apply to bioethical questions about life and death? In this
      paper, we analyze the arguments for, and against, the acceptance of brain death
      within the context of the deliberation of a representative juridical council. In 
      our discussion we focus on areas in which the legists' ethico-legal reasoning
      hinges upon clinical conceptions of the state of the individual when diagnosed as
      brain dead. As Islamic ethics continues to engage scientific and technological
      advancements in these areas, such exploration of internal workings is necessary
      if we wish to better understand how Islamic ethical principles can contribute to 
      bioethical deliberation.
FAU - Padela, Aasim I
AU  - Padela AI
AD  - Program on Medicine and Religion, Section of General Internal Medicine,
      Department of Medicine, University of Chicago, Chicago, IL, USA.
      apadela@uchicago.edu
FAU - Basser, Taha A
AU  - Basser TA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Med Law
JT  - Medicine and law
JID - 8218185
SB  - IM
MH  - *Bioethical Issues
MH  - Brain Death/*legislation & jurisprudence
MH  - Humans
MH  - *Islam
EDAT- 2012/12/20 06:00
MHDA- 2013/03/13 06:00
CRDT- 2012/12/20 06:00
PHST- 2012/12/20 06:00 [entrez]
PHST- 2012/12/20 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
PST - ppublish
SO  - Med Law. 2012 Sep;31(3):433-50.


PMID- 23248838
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20170203
IS  - 0723-1393 (Print)
IS  - 0723-1393 (Linking)
VI  - 31
IP  - 3
DP  - 2012 Sep
TI  - Current trends in medical ethics education in Japanese medical schools.
PG  - 365-74
AB  - The Japanese medical education program has radically improved during the last 10 
      years. In 1999, the Task Force Committee on Innovation of Medical Education for
      the 21st Century proposed a tutorial education system, a core curriculum, and a
      medical student evaluation system for clinical clerkship. In 2001, the Model Core
      Curriculum of medical education was instituted, in which medical ethics became
      part of the core material. Since 2005, a nationwide medical student evaluation
      system has been applied for entrance to clinical clerkship. Within the Japan
      Society for Medical Education, the Working Group of Medical Ethics proposed a
      medical ethics education curriculum in 2001. In line with this, the Japanese
      Association for Philosophical and Ethical Research in Medicine has begun to
      address the standardization of the curriculum of medical ethics. A medical
      philosophy curriculum should also be included in considering illness, health,
      life, death, the body, and human welfare.
FAU - Kurosu, Mitsuyasu
AU  - Kurosu M
AD  - Department of Bioethics (Medical Ethics), Tokyo Medical University, 6-1-1
      Shinjuku, Shinjuku-ku, Tokyo. krs-uou@tokyo-med.ac.jp
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Law
JT  - Medicine and law
JID - 8218185
SB  - IM
MH  - *Clinical Clerkship
MH  - *Curriculum
MH  - *Education, Medical, Undergraduate
MH  - Ethics, Medical/*education
MH  - Humans
MH  - Japan
MH  - Schools, Medical
EDAT- 2012/12/20 06:00
MHDA- 2013/03/13 06:00
CRDT- 2012/12/20 06:00
PHST- 2012/12/20 06:00 [entrez]
PHST- 2012/12/20 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
PST - ppublish
SO  - Med Law. 2012 Sep;31(3):365-74.


PMID- 23248837
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20170203
IS  - 0723-1393 (Print)
IS  - 0723-1393 (Linking)
VI  - 31
IP  - 3
DP  - 2012 Sep
TI  - Cardiovascular implantable electronic devices: patient education, information and
      ethical issues.
PG  - 355-63
AB  - Cardiovascular implantable electronic devices (CIED) are implanted increasingly
      frequently. CIEDs are indicated for the treatment of bradycardia, tachycardia and
      heart failure and therefore improve quality of life and life expectancy. CIED can
      treat ventricular arrhythmias that would be fatal without immediate care.
      However, CIEDs raise several patient education, medico-legal, and ethical
      questions that will be addressed in this article. Information is a patient's
      right, and necessary for informed consent. When implanting a CIED, the patient
      must be educated about the need for the device, the function of the device, any
      restrictions that apply postimplant, and postimplant follow-up methods and
      schedules. This transfer of information to the patient makes the patient
      responsible. The occupational physician can determine whether a patient wearing a
      CIED is able to work. Under current French law, patients are not prohibited from 
      working while wearing a CIED. However, access to certain job categories remains
      limited, such as jobs involving mechanical stress to the chest, exposure to
      electromagnetic fields, or jobs requiring permanent vigilance. Pacemakers and
      defibrillators are medical treatments and are subject to the same ethical and
      clinical considerations as any other treatment. However, stopping a pacemaker or 
      a defibrillator raises different ethical issues. Implantable Cardioverter
      Defibrillator shocks can be considered to be equivalent to resuscitation efforts 
      and can be interpreted as being unreasonable in an end-of-life patient. Pacing is
      painless and it is unlikely to unnecessarily prolong the life of a patient with a
      terminal disease. Patients with a CIED should live as normally as possible, but
      must also be informed about the constraints related to the device and must inform
      each caregiver about the presence of the device. The forensic and ethical
      implications must be assessed in relation to current legislation.
FAU - Manaouil, Cecile
AU  - Manaouil C
AD  - MCU-PH, Forensic and Medical Law Unit, Amiens University Hospital, Amiens,
      France. manaouil.cecile@chu-amiens.fr
FAU - Gignon, Maxime
AU  - Gignon M
FAU - Traulle, Sarah
AU  - Traulle S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Law
JT  - Medicine and law
JID - 8218185
SB  - IM
MH  - *Defibrillators, Implantable
MH  - *Ethics, Medical
MH  - France
MH  - Humans
MH  - Informed Consent/legislation & jurisprudence
MH  - *Pacemaker, Artificial
MH  - *Patient Education as Topic
MH  - Work Capacity Evaluation
EDAT- 2012/12/20 06:00
MHDA- 2013/03/13 06:00
CRDT- 2012/12/20 06:00
PHST- 2012/12/20 06:00 [entrez]
PHST- 2012/12/20 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
PST - ppublish
SO  - Med Law. 2012 Sep;31(3):355-63.


PMID- 30100662
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1097-0258 (Electronic)
IS  - 0277-6715 (Linking)
VI  - 31
IP  - 29
DP  - 2012 Dec 20
TI  - Power, Ethics and Obligation.
PG  - 4140-4141
LID - 10.1002/sim.5578 [doi]
FAU - Gelfond, Jonathan Adam
AU  - Gelfond JA
AD  - UT Health Science Center San Antonio, Department of Epidemiology and
      Biostatistics, Mail Code 7933, 7703 Floyd Curl Drive, San Antonio, Texas
      78229-3900, U.S.A.
FAU - Heitman, Elizabeth
AU  - Heitman E
AD  - Vanderbilt University Medical Center, Center for Biomedical Ethics and Society,
      2525 West End Avenue, Suite 400, Nashville, Tennessee 37203, U.S.A.
FAU - Pollock, Brad H
AU  - Pollock BH
AD  - UT Health Science Center San Antonio, Department of Epidemiology and
      Biostatistics, San Antonio, Texas 78229-3900, U.S.A.
FAU - Klugman, Craig H
AU  - Klugman CH
AD  - UT Health Science Center San Antonio, Department of Medicine, San Antonio, Texas 
      78229, U.S.A.
LA  - eng
GR  - UL1 RR025767/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Comment
DEP - 20121123
PL  - England
TA  - Stat Med
JT  - Statistics in medicine
JID - 8215016
CON - Am J Epidemiol. 2005 Jan 15;161(2):105-10. PMID: 15632258
CON - Biometrics. 2008 Jun;64(2):577-85; discussion 586-94. PMID: 18482055
PMC - PMC6082657
MID - NIHMS405329
EDAT- 2012/12/20 00:00
MHDA- 2012/12/20 00:01
CRDT- 2018/08/14 06:00
PHST- 2018/08/14 06:00 [entrez]
PHST- 2012/12/20 00:00 [pubmed]
PHST- 2012/12/20 00:01 [medline]
AID - 10.1002/sim.5578 [doi]
PST - ppublish
SO  - Stat Med. 2012 Dec 20;31(29):4140-4141. doi: 10.1002/sim.5578. Epub 2012 Nov 23.


PMID- 23248761
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121219
LR  - 20220729
IS  - 2153-3539 (Electronic)
VI  - 3
DP  - 2012
TI  - Next generation sequencing in clinical medicine: Challenges and lessons for
      pathology and biomedical informatics.
PG  - 40
LID - 10.4103/2153-3539.103013 [doi]
AB  - The Human Genome Project (HGP) provided the initial draft of mankind's DNA
      sequence in 2001. The HGP was produced by 23 collaborating laboratories using
      Sanger sequencing of mapped regions as well as shotgun sequencing techniques in a
      process that occupied 13 years at a cost of ~$3 billion. Today, Next Generation
      Sequencing (NGS) techniques represent the next phase in the evolution of DNA
      sequencing technology at dramatically reduced cost compared to traditional Sanger
      sequencing. A single laboratory today can sequence the entire human genome in a
      few days for a few thousand dollars in reagents and staff time. Routine whole
      exome or even whole genome sequencing of clinical patients is well within the
      realm of affordability for many academic institutions across the country. This
      paper reviews current sequencing technology methods and upcoming advancements in 
      sequencing technology as well as challenges associated with data generation, data
      manipulation and data storage. Implementation of routine NGS data in cancer
      genomics is discussed along with potential pitfalls in the interpretation of the 
      NGS data. The overarching importance of bioinformatics in the clinical
      implementation of NGS is emphasized.[7] We also review the issue of physician
      education which also is an important consideration for the successful
      implementation of NGS in the clinical workplace. NGS technologies represent a
      golden opportunity for the next generation of pathologists to be at the leading
      edge of the personalized medicine approaches coming our way. Often
      under-emphasized issues of data access and control as well as potential ethical
      implications of whole genome NGS sequencing are also discussed. Despite some
      challenges, it's hard not to be optimistic about the future of personalized
      genome sequencing and its potential impact on patient care and the advancement of
      knowledge of human biology and disease in the near future.
FAU - Gullapalli, Rama R
AU  - Gullapalli RR
AD  - Department of Pathology, University of Pittsburgh Medical Centre, A701, Scaife
      Hall, 3550 Terrace Street, Pittsburgh, PA.
FAU - Desai, Ketaki V
AU  - Desai KV
FAU - Santana-Santos, Lucas
AU  - Santana-Santos L
FAU - Kant, Jeffrey A
AU  - Kant JA
FAU - Becich, Michael J
AU  - Becich MJ
LA  - eng
PT  - Journal Article
DEP - 20121031
PL  - United States
TA  - J Pathol Inform
JT  - Journal of pathology informatics
JID - 101528849
PMC - PMC3519097
OTO - NOTNLM
OT  - Bioinformatics
OT  - clinical medicine
OT  - next generation sequencing
OT  - pathology
EDAT- 2012/12/19 06:00
MHDA- 2012/12/19 06:01
CRDT- 2012/12/19 06:00
PHST- 2012/03/15 00:00 [received]
PHST- 2012/07/19 00:00 [accepted]
PHST- 2012/12/19 06:00 [entrez]
PHST- 2012/12/19 06:00 [pubmed]
PHST- 2012/12/19 06:01 [medline]
AID - 10.4103/2153-3539.103013 [doi]
AID - S2153-3539(22)00614-9 [pii]
PST - ppublish
SO  - J Pathol Inform. 2012;3:40. doi: 10.4103/2153-3539.103013. Epub 2012 Oct 31.


PMID- 23248573
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121219
LR  - 20211021
IS  - 1178-203X (Electronic)
IS  - 1176-6336 (Linking)
VI  - 8
DP  - 2012
TI  - Interventions performed by community pharmacists in one Canadian province: a
      cross-sectional study.
PG  - 415-21
LID - 10.2147/TCRM.S37581 [doi]
AB  - PURPOSE: Interventions made by pharmacists to resolve issues when filling a
      prescription ensure the quality, safety, and efficacy of medication therapy for
      patients. The purpose of this study was to provide a current estimate of the
      number and types of interventions performed by community pharmacists during
      processing of prescriptions. This baseline data will provide insight into the
      factors influencing current practice and areas where pharmacists can redefine and
      expand their role. PATIENTS AND METHODS: A cross-sectional study of community
      pharmacist interventions was completed. Participants included third-year pharmacy
      students and their pharmacist preceptor as a data collection team. The team
      identified all interventions on prescriptions during the hours worked together
      over a 7-day consecutive period. Full ethics approval was obtained. RESULTS: Nine
      student-pharmacist pairs submitted data from nine pharmacies in rural (n = 3) and
      urban (n = 6) centers. A total of 125 interventions were documented for 106
      patients, with a mean intervention rate of 2.8%. The patients were 48% male, were
      mostly >/=18 years of age (94%), and 86% had either public or private insurance. 
      Over three-quarters of the interventions (77%) were on new prescriptions. The top
      four types of problems requiring intervention were related to prescription
      insurance coverage (18%), drug product not available (16%), dosage too low (16%),
      and missing prescription information (15%). The prescriber was contacted for 69% 
      of the interventions. Seventy-two percent of prescriptions were changed and by
      the end of the data collection period, 89% of the problems were resolved.
      CONCLUSION: Community pharmacists are impacting the care of patients by
      identifying and resolving problems with prescriptions. Many of the issues
      identified in this study were related to correcting administrative or technical
      issues, potentially limiting the time pharmacists can spend on patient-focused
      activities.
FAU - Young, Stephanie W
AU  - Young SW
AD  - School of Pharmacy, Memorial University of Newfoundland, St John's, Newfoundland 
      and Labrador, Canada.
FAU - Bishop, Lisa D
AU  - Bishop LD
FAU - Conway, Amy
AU  - Conway A
LA  - eng
PT  - Journal Article
DEP - 20121206
PL  - New Zealand
TA  - Ther Clin Risk Manag
JT  - Therapeutics and clinical risk management
JID - 101253281
PMC - PMC3520548
OTO - NOTNLM
OT  - Canada
OT  - drug-related problems
OT  - medications
OT  - pharmaceutical care
OT  - pharmacy
OT  - prescriptions
EDAT- 2012/12/19 06:00
MHDA- 2012/12/19 06:01
CRDT- 2012/12/19 06:00
PHST- 2012/12/19 06:00 [entrez]
PHST- 2012/12/19 06:00 [pubmed]
PHST- 2012/12/19 06:01 [medline]
AID - 10.2147/TCRM.S37581 [doi]
AID - tcrm-8-415 [pii]
PST - ppublish
SO  - Ther Clin Risk Manag. 2012;8:415-21. doi: 10.2147/TCRM.S37581. Epub 2012 Dec 6.


PMID- 23248390
OWN - NLM
STAT- MEDLINE
DCOM- 20130522
LR  - 20211021
IS  - 1998-3751 (Electronic)
IS  - 0253-7613 (Linking)
VI  - 44
IP  - 6
DP  - 2012 Nov-Dec
TI  - Ethics committee: critical issues and challenges.
PG  - 663-4
LID - 10.4103/0253-7613.103233 [doi]
FAU - Desai, Mira
AU  - Desai M
LA  - eng
PT  - Editorial
PL  - India
TA  - Indian J Pharmacol
JT  - Indian journal of pharmacology
JID - 7902477
SB  - IM
MH  - *Ethics Committees, Clinical
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Professional Competence
MH  - Therapeutic Human Experimentation/*ethics
MH  - Vulnerable Populations
PMC - PMC3523488
EDAT- 2012/12/19 06:00
MHDA- 2013/05/23 06:00
CRDT- 2012/12/19 06:00
PHST- 2012/12/19 06:00 [entrez]
PHST- 2012/12/19 06:00 [pubmed]
PHST- 2013/05/23 06:00 [medline]
AID - 10.4103/0253-7613.103233 [doi]
AID - IJPharm-44-663 [pii]
PST - ppublish
SO  - Indian J Pharmacol. 2012 Nov-Dec;44(6):663-4. doi: 10.4103/0253-7613.103233.


PMID- 23247984
OWN - NLM
STAT- MEDLINE
DCOM- 20130821
LR  - 20211021
IS  - 1556-2891 (Electronic)
IS  - 1547-769X (Linking)
VI  - 9
IP  - 1
DP  - 2013 Mar
TI  - Colposcopic photography of genital injury following sexual intercourse in adults.
PG  - 24-30
LID - 10.1007/s12024-012-9394-2 [doi]
AB  - The aim of this study was to evaluate interpretations and the reproducibility of 
      interpretations when looking at colposcopic photographs in a forensic setting, as
      well as discussing some of the dilemmas and pitfalls of forensic colposcopic
      photography. A total of 316 colposcopic photographs from 51 women taken on three 
      occasions following consensual sexual intercourse, and 78 colposcopic photographs
      from 39 rape victims, were evaluated by four different observers. Photographs
      were taken in the same setting, by the same group of investigators, before and
      after application of toluidine blue dye. The overall Kappa-value for the four
      observers' judgment of lesion vs. no lesion was 0.41 which can be interpreted as 
      moderate agreement. Intra-observer agreement was calculated for two of the
      observers looking at photographs with a 10 months' time-gap, and the Kappa-values
      were 0.41 and 0.52. Positive and negative predictive values of the photographs
      were 82 and 81 % respectively. This study demonstrates relatively poor
      reliability of colposcopic photography. Some would argue that this makes
      colposcopic photography a low-quality method of evaluation and that forensic
      science should aim for higher standards because of its use in court. Others would
      argue that as long as the limitations of a scientific method are acknowledged
      then it is still eligible for use. The moderate agreement and accuracy stresses
      the need for quality control in the gynecological part of a rape examination.
      Colposcopic photography also provides a good option for supervision and teaching 
      in an ethically difficult setting. It strengthens the legal rights for both
      victim and perpetrator.
FAU - Astrup, Birgitte Schmidt
AU  - Astrup BS
AD  - Department of Forensic Pathology, Institute of Forensic Medicine, University of
      Southern Denmark, J.B. Winslowsvej 17, 5000, Odense C, Denmark.
      birgitte@schmidtastrup.dk
FAU - Lauritsen, Jens
AU  - Lauritsen J
FAU - Thomsen, Jorgen Lange
AU  - Thomsen JL
FAU - Ravn, Pernille
AU  - Ravn P
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20121218
PL  - United States
TA  - Forensic Sci Med Pathol
JT  - Forensic science, medicine, and pathology
JID - 101236111
RN  - 0 (Coloring Agents)
RN  - 15XUH0X66N (Tolonium Chloride)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - *Coitus
MH  - Coloring Agents
MH  - *Colposcopy
MH  - Contusions/pathology
MH  - Female
MH  - Forensic Pathology/*methods
MH  - Genitalia, Female/*injuries
MH  - Hematoma/pathology
MH  - Humans
MH  - Lacerations/pathology
MH  - Observer Variation
MH  - *Photography
MH  - Predictive Value of Tests
MH  - *Rape
MH  - Reproducibility of Results
MH  - Tolonium Chloride
MH  - Wounds and Injuries/*pathology
EDAT- 2012/12/19 06:00
MHDA- 2013/08/22 06:00
CRDT- 2012/12/19 06:00
PHST- 2012/11/07 00:00 [accepted]
PHST- 2012/12/19 06:00 [entrez]
PHST- 2012/12/19 06:00 [pubmed]
PHST- 2013/08/22 06:00 [medline]
AID - 10.1007/s12024-012-9394-2 [doi]
PST - ppublish
SO  - Forensic Sci Med Pathol. 2013 Mar;9(1):24-30. doi: 10.1007/s12024-012-9394-2.
      Epub 2012 Dec 18.


PMID- 23245707
OWN - NLM
STAT- MEDLINE
DCOM- 20140218
LR  - 20211021
IS  - 1873-491X (Electronic)
IS  - 0020-7489 (Linking)
VI  - 50
IP  - 9
DP  - 2013 Sep
TI  - Ethical and legal issues in pain research in cognitively impaired older adults.
PG  - 1283-7
LID - 10.1016/j.ijnurstu.2012.11.023 [doi]
LID - S0020-7489(12)00425-7 [pii]
AB  - Research involving those with dementia is critical to informing best practices
      and improving the quality of their lives. Pain research in people with dementia
      is of particular interest because the prevalence of both dementia and painful
      conditions increases with age. Considerable evidence exists documenting
      inadequate assessment and treatment of pain in this vulnerable population.
      Unfortunately, research that supports best practices for assessing and treating
      pain in the cognitively impaired is limited with obstacles to conducting
      research. Obstacles to research in older adults, including those with cognitive
      impairment, have been highlighted along with an urgent call for increased
      research to promote quality pain care for all older adults. The aims of this
      paper are to provide an overview of major ethical challenges that can occur in
      pain research in cognitively impaired populations and to present potential
      solutions when preparing study protocols.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Monroe, Todd B
AU  - Monroe TB
AD  - School of Nursing, Vanderbilt University, Institute of Imaging Science,
      Vanderbilt University, 461 21st Avenue South, Nashville, TN 37240, USA.
      todd.b.monroe@vanderbilt.edu
FAU - Herr, Keela A
AU  - Herr KA
FAU - Mion, Lorraine C
AU  - Mion LC
FAU - Cowan, Ronald L
AU  - Cowan RL
LA  - eng
GR  - KL2 RR024977/RR/NCRR NIH HHS/United States
GR  - TL1 RR024978/RR/NCRR NIH HHS/United States
GR  - UL1 RR024975/RR/NCRR NIH HHS/United States
GR  - UL1 TR000445/TR/NCATS NIH HHS/United States
PT  - Journal Article
DEP - 20121214
PL  - England
TA  - Int J Nurs Stud
JT  - International journal of nursing studies
JID - 0400675
SB  - IM
MH  - Aged
MH  - Dementia/*complications
MH  - *Ethics
MH  - Guidelines as Topic
MH  - Humans
MH  - Pain/*complications
MH  - Risk Assessment
PMC - PMC3612555
MID - NIHMS426951
OTO - NOTNLM
OT  - Cognitive impairment
OT  - Dementia pain
OT  - Ethics
OT  - Protection of human subjects
OT  - Research methods
EDAT- 2012/12/19 06:00
MHDA- 2014/02/19 06:00
CRDT- 2012/12/19 06:00
PHST- 2012/06/22 00:00 [received]
PHST- 2012/11/17 00:00 [revised]
PHST- 2012/11/27 00:00 [accepted]
PHST- 2012/12/19 06:00 [entrez]
PHST- 2012/12/19 06:00 [pubmed]
PHST- 2014/02/19 06:00 [medline]
AID - S0020-7489(12)00425-7 [pii]
AID - 10.1016/j.ijnurstu.2012.11.023 [doi]
PST - ppublish
SO  - Int J Nurs Stud. 2013 Sep;50(9):1283-7. doi: 10.1016/j.ijnurstu.2012.11.023. Epub
      2012 Dec 14.


PMID- 23245406
OWN - NLM
STAT- MEDLINE
DCOM- 20131202
LR  - 20191210
IS  - 1460-9576 (Electronic)
IS  - 0968-8080 (Linking)
VI  - 20
IP  - 40
DP  - 2012 Dec
TI  - The creation of "monsters": the discourse of opposition to in vitro fertilization
      in Poland.
PG  - 30-7
LID - 10.1016/S0968-8080(12)40647-4 [doi]
LID - S0968-8080(12)40647-4 [pii]
AB  - In Poland, there is a campaign to criminalise in vitro fertilization, led by the 
      Catholic church. This article explores how this campaign makes "monsters" of IVF 
      children in its discourse, that is, embodiments of "the other" in the sense of
      Frankenstein's monster. Basing the analysis primarily on Catholic mass media
      publications, the article investigates the discursive strategies employed to
      oppose IVF, most notably by the Catholic clergy and activists and journalists
      associated with the Church. They attribute "monstrosity" to the children in the
      following ways: physical (possible bodily deformity), psychological (survivor
      syndrome, identity crisis), social (loneliness, uncertain place in family
      relations), and ethical (a life burdened with the deaths of many embryos).
      Although the world of families with IVF does not provide examples of children who
      could be considered monsters in any of these terms, these arguments have become
      the primary reasons given for banning IVF.
CI  - Copyright (c) 2012 Reproductive Health Matters. Published by Elsevier Ltd. All
      rights reserved.
FAU - Radkowska-Walkowicz, Magdalena
AU  - Radkowska-Walkowicz M
AD  - Institute of Ethnology and Cultural Anthropology, University of Warsaw, Warsaw,
      Poland. m.radkowska-walkowicz@uw.edu.pl
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Reprod Health Matters
JT  - Reproductive health matters
JID - 9420826
SB  - IM
MH  - *Catholicism
MH  - *Conflict, Psychological
MH  - *Fertilization in Vitro/psychology
MH  - Humans
MH  - Poland
MH  - *Prejudice
MH  - *Religion and Medicine
EDAT- 2012/12/19 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/12/19 06:00
PHST- 2012/12/19 06:00 [entrez]
PHST- 2012/12/19 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - S0968-8080(12)40647-4 [pii]
AID - 10.1016/S0968-8080(12)40647-4 [doi]
PST - ppublish
SO  - Reprod Health Matters. 2012 Dec;20(40):30-7. doi: 10.1016/S0968-8080(12)40647-4.


PMID- 23244147
OWN - NLM
STAT- MEDLINE
DCOM- 20130604
LR  - 20211203
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Linking)
VI  - 13
IP  - 10
DP  - 2012
TI  - Chinese patients with gastric cancer need targeted adjuvant chemotherapy schemes.
PG  - 5263-72
AB  - BACKGROUND: Gastric cancer (GC) is one of the most common cancers in China.
      Adjuvant chemotherapy (AC) is a routine auxiliary treatment for GC recommended by
      the guidelines issued in 2011 by the Ministry of Health of the People's Republic 
      of China, but the relevant credible consequences in China have been insufficient 
      because of China's late start and ethical concerns. METHODS: A series of
      databases, including Cochrane Library, MEDLINE, EMBASE, the Chinese database of
      the National Knowledge Infrastructure and the VIP database, were searched by 2
      reviewers independently for studies investigating AC for GC through March 2012.
      The retrieved literature was screened according to the eligibility criteria.
      RESULTS: A total of 35 randomized control trials (RCTs) were subjected to the
      final analysis, including 4,043 patients in treatment group and 3,884 in the
      control group, as well as 4 clinical-control trials (CCTs), which accessed the
      final analysis with 238 and 252 patients, respectively. AC reduced the risk of
      death as a protective treatment with statistical significance (HR=0.91, 95%CI:
      [0.85, 0.97], P=0.002), and it seemed more effective for Asian than non-Asian
      patients. The effects of AC were not influenced by the starting time (P>0.05). D2
      lymphadenectomy-based chemotherapy was effective (HR=0.89, 95%CI: [0.80, 0.99],
      P=0.04). Oral S-1 40 mg/m2 after D2 lymphadenectomy might be a better choice for 
      Asians with advanced GC and might result in a greater reduction of adverse events
      than in non-Asian patients. GRADE quality assessment determined that the strength
      of the evidence from foreign studies from Europe, the United States and Asian
      countries other than China was high, while it was moderate for Chinese studies.
      CONCLUSION: AC was effective or even curative in Chinese patients in general,
      although it is still necessary to optimize a targeted AC scheme for Chinese
      patients with GC.
FAU - Shi, Wen-Tao
AU  - Shi WT
AD  - Department of Oncology, Zhongnan Hospital, Hubei Key Laboratory of Tumor
      Biological Behavior, Hubei Cancer Clinical Study Center, China.
FAU - Wei, Lei
AU  - Wei L
FAU - Xiang, Jin
AU  - Xiang J
FAU - Su, Ke
AU  - Su K
FAU - Ding, Qiong
AU  - Ding Q
FAU - Tang, Meng-Jie
AU  - Tang MJ
FAU - Li, Ji-Qiang
AU  - Li JQ
FAU - Guo, Yi
AU  - Guo Y
FAU - Wang, Pu
AU  - Wang P
FAU - Zhang, Jing-Wei
AU  - Zhang JW
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Antineoplastic Agents/*therapeutic use
MH  - Asians
MH  - Chemotherapy, Adjuvant
MH  - Humans
MH  - Prognosis
MH  - Randomized Controlled Trials as Topic
MH  - Review Literature as Topic
MH  - Stomach Neoplasms/*drug therapy
EDAT- 2012/12/19 06:00
MHDA- 2013/06/05 06:00
CRDT- 2012/12/19 06:00
PHST- 2012/12/19 06:00 [entrez]
PHST- 2012/12/19 06:00 [pubmed]
PHST- 2013/06/05 06:00 [medline]
AID - 10.7314/apjcp.2012.13.10.5263 [doi]
PST - ppublish
SO  - Asian Pac J Cancer Prev. 2012;13(10):5263-72. doi: 10.7314/apjcp.2012.13.10.5263.


PMID- 23244009
OWN - NLM
STAT- MEDLINE
DCOM- 20130529
LR  - 20121218
IS  - 1943-281X (Electronic)
IS  - 0033-2747 (Linking)
VI  - 75
IP  - 4
DP  - 2012 Winter
TI  - Practical legal and ethical considerations for the provision of acute disaster
      mental health services.
PG  - 305-22
LID - 10.1521/psyc.2012.75.4.305 [doi]
AB  - Mental health professionals who provide emergency psychosocial assistance in the 
      immediate aftermath of disasters do so in the midst of crisis and chaos. Common
      roles undertaken by disaster mental health professionals include treating
      existing conditions of disaster survivors and providing psychosocial support to
      front line responders and those acutely affected. Other roles include
      participating in multidisciplinary health care teams as well as monitoring and
      supporting team members' mental health. When, in the immediate aftermath of a
      disaster, mental health professionals provide such assistance, they may take on
      legal and ethical responsibilities that they are not fully aware of or do not
      fully comprehend. Unfortunately, not much has been written about these
      obligations, and professional organizations have provided little guidance. Thus, 
      the purpose of the present article is to outline and discuss an analysis
      framework and suggest recommendations that mental health professionals can use to
      help guide their actions during the chaos immediate post disaster.
FAU - Call, John A
AU  - Call JA
AD  - Crisis Management Consultants, Inc, in Edmond, Oklahoma, USA. cmc@crisisinc.com
FAU - Pfefferbaum, Betty
AU  - Pfefferbaum B
FAU - Jenuwine, Michael J
AU  - Jenuwine MJ
FAU - Flynn, Brian W
AU  - Flynn BW
LA  - eng
GR  - 1 U79 SM57278/SM/CMHS SAMHSA HHS/United States
GR  - R25 MH070569/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Psychiatry
JT  - Psychiatry
JID - 0376470
SB  - IM
CIN - Psychiatry. 2012 Winter;75(4):323-30. PMID: 23244010
MH  - Clinical Competence/legislation & jurisprudence/standards
MH  - Codes of Ethics/legislation & jurisprudence
MH  - Confidentiality/ethics/legislation & jurisprudence
MH  - *Disasters
MH  - Emergency Medical Services/ethics/*legislation & jurisprudence
MH  - Evidence-Based Practice
MH  - Guidelines as Topic
MH  - Humans
MH  - Interprofessional Relations
MH  - Liability, Legal
MH  - Licensure/ethics/*legislation & jurisprudence
MH  - Mental Health Services/*ethics/*legislation & jurisprudence
MH  - Patient Care Team
MH  - Physician-Patient Relations/ethics
MH  - Professional Role
MH  - Psychology
MH  - Survivors/*psychology
MH  - Terminology as Topic
EDAT- 2012/12/19 06:00
MHDA- 2013/05/31 06:00
CRDT- 2012/12/19 06:00
PHST- 2012/12/19 06:00 [entrez]
PHST- 2012/12/19 06:00 [pubmed]
PHST- 2013/05/31 06:00 [medline]
AID - 10.1521/psyc.2012.75.4.305 [doi]
PST - ppublish
SO  - Psychiatry. 2012 Winter;75(4):305-22. doi: 10.1521/psyc.2012.75.4.305.


PMID- 23243989
OWN - NLM
STAT- MEDLINE
DCOM- 20130918
LR  - 20220408
IS  - 1343-4292 (Print)
IS  - 1343-4292 (Linking)
IP  - 130
DP  - 2012
TI  - [Studies on the food allergenic proteins contained in pharmaceutical excipients].
PG  - 58-65
AB  - Most drugs contain pharmaceutical excipients. These are pharmacologically
      inactive substances used as vehicles for the active ingredients of a medication. 
      Some of these pharmaceutical excipients are produced from allergenic foods (e.g.,
      milk, egg, peanut, soybean, and sesame) and removing proteins completely from
      such excipients is difficult. Therefore, if individuals with food allergy consume
      drugs containing allergenic food-derived excipients, eliminating the risk of
      developing specific allergic symptoms induced by them may not be possible. We
      determined the levels of proteins in pharmaceutical excipients and ethical drugs 
      (inhalants and injections) by spectrophotometric analyses. The level of protein
      in the pharmaceutical excipient lactose in each sample was approximately 1 mg/g. 
      In the case of oils from soybeans, peanuts, and sesame in pharmaceutical
      excipients, proteins were detected in the range 7-9 microg/g sample. We also
      determined levels of allergenic proteins in pharmaceutical excipients and ethical
      drugs using commercial enzyme-linked immunosorbent assay systems. The milk
      proteins in lactose were detected in the range 1.39-13.07 microg/g. The results
      of this study suggest that physicians, patients with food allergies, pharmacists,
      and healthcare providers must pay attention to presence of potential impurities
      those may cause allergic symptoms in pharmaceutical products.
FAU - Sakai, Shinobu
AU  - Sakai S
AD  - Division of Novel Foods and Immunochemistry, National Institute of Health
      Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan.
FAU - Adachi, Reiko
AU  - Adachi R
FAU - Miyazaki, Tamaki
AU  - Miyazaki T
FAU - Aso, Yukio
AU  - Aso Y
FAU - Okuda, Haruhiro
AU  - Okuda H
FAU - Teshima, Reiko
AU  - Teshima R
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku
JT  - Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National
      Institute of Health Sciences
JID - 9807834
RN  - 0 (Adjuvants, Pharmaceutic)
RN  - 0 (Allergens)
RN  - 0 (Milk Proteins)
RN  - 0 (Pharmaceutical Preparations)
RN  - 0 (Proteins)
RN  - J2B2A4N98G (Lactose)
SB  - IM
MH  - Adjuvants, Pharmaceutic/adverse effects/*chemistry
MH  - Allergens/adverse effects/*analysis
MH  - Drug Hypersensitivity/etiology/*prevention & control
MH  - Drug-Related Side Effects and Adverse Reactions
MH  - Enzyme-Linked Immunosorbent Assay
MH  - *Food Hypersensitivity
MH  - Humans
MH  - Lactose/adverse effects/analysis
MH  - Milk Proteins/adverse effects/analysis
MH  - Pharmaceutical Preparations/*chemistry
MH  - Proteins/adverse effects/*analysis
MH  - Spectrophotometry
EDAT- 2012/12/19 06:00
MHDA- 2013/09/21 06:00
CRDT- 2012/12/19 06:00
PHST- 2012/12/19 06:00 [entrez]
PHST- 2012/12/19 06:00 [pubmed]
PHST- 2013/09/21 06:00 [medline]
PST - ppublish
SO  - Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku. 2012;(130):58-65.


PMID- 23221269
OWN - NLM
STAT- MEDLINE
DCOM- 20131212
LR  - 20121211
IS  - 2219-6749 (Electronic)
IS  - 0258-414X (Linking)
VI  - 30 Suppl 1
DP  - 2012 Nov 30
TI  - Ethics in age estimation of unaccompanied minors.
PG  - 84-102
AB  - Children absconding from countries of conflict and war are often not able to
      document their age. When an age is given, it is frequently untraceable or poorly 
      documented and therefore questioned by immigration authorities. Consequently many
      countries perform age estimations on these children. Provision of ethical
      practice during the age estimation investigation of unaccompanied minors is
      considered from different angles: (1) The UN convention on children's rights,
      formulating specific rights, protection, support, healthcare and education for
      unaccompanied minors. (2) Since most age estimation investigations are based on
      medical examination, the four basic principles of biomedical ethics, namely
      autonomy, beneficence, non-malevolence, justice. (3) The use of medicine for non 
      treatment purposes. (4) How age estimates with highest accuracy in age prediction
      can be obtained. Ethical practice in age estimation of unaccompanied minors is
      achieved when different but related aspects are searched, evaluated, weighted in 
      importance and subsequently combined. However this is not always feasible and
      unanswered questions remain.
FAU - Thevissen, P W
AU  - Thevissen PW
AD  - Department of Oral Health Sciences, KU Leuven and Dentistry, University Hospitals
      Leuven, Belgium.
FAU - Kvaal, S I
AU  - Kvaal SI
FAU - Willems, G
AU  - Willems G
LA  - eng
PT  - Journal Article
DEP - 20121130
PL  - Australia
TA  - J Forensic Odontostomatol
JT  - The Journal of forensic odonto-stomatology
JID - 8501421
MH  - Age Determination by Skeleton/*ethics
MH  - *Age Determination by Teeth
MH  - Belgium
MH  - Beneficence
MH  - Child
MH  - Child Advocacy/legislation & jurisprudence
MH  - Databases, Factual
MH  - Documentation
MH  - *Emigrants and Immigrants/legislation & jurisprudence
MH  - *Ethics, Clinical
MH  - European Union
MH  - Female
MH  - Human Rights/legislation & jurisprudence
MH  - Humans
MH  - Informed Consent/legislation & jurisprudence
MH  - Male
MH  - *Minors/legislation & jurisprudence
MH  - Personal Autonomy
MH  - Physical Examination/ethics
MH  - Quality of Life
MH  - Social Justice
MH  - Stress, Psychological/prevention & control
MH  - United Nations
MH  - Vulnerable Populations/legislation & jurisprudence
EDAT- 2012/12/19 06:00
MHDA- 2013/12/18 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/19 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
PST - epublish
SO  - J Forensic Odontostomatol. 2012 Nov 30;30 Suppl 1:84-102.


PMID- 23221268
OWN - NLM
STAT- MEDLINE
DCOM- 20131212
LR  - 20191210
IS  - 2219-6749 (Electronic)
IS  - 0258-414X (Linking)
VI  - 30 Suppl 1
DP  - 2012 Nov 30
TI  - Professionalism: challenges for dentistry in the future.
PG  - 72-84
AB  - While countries varies significantly in the financing of dental care, they are
      much more alike in the delivery of dentistry. Dental care is principally provided
      in dental offices and clinics that are independent business entities whose
      business leaders are most often the dentists themselves. However society expects 
      from dentists a level of professionalism (i.e. habitually acting ethically, both 
      in terms of competence and conduct) in contrast to the methods and motivations of
      the marketplace. This is why the single most important challenge of dental
      professional ethics continues to be giving proper priority to patients' well
      being and building ethically correct decision-making relationships with patients 
      while, at the same time, trying to maintain a successful business operation. If
      we look into dentistry's future, the centrality of this aspect of professional
      ethics is not likely to change, although the ways in which dentists might violate
      this trust will probably multiple as funding mechanisms become increasingly
      complex. It is important that dentists reflect with fresh eyes on their ethical
      commitments. One challenge is the increased availability of oral health
      information to the public and the fact that so many people are uncritical of the 
      accuracy of information in the media and on the web. A second is the increase in 
      the amount of health care advertising in many societies. A third is the growth of
      aesthetic dentistry that differs from standard oral health care in important and 
      ethically significant ways. The fourth is insurance that frequently complicates
      the explanation of a patient's treatment alternatives and often brings a third
      party into the treatment decision relationship. The ethical challenges of each of
      these factors will be considered and ultimately tying it to the central theme of 
      dental professionalism.
FAU - Ozar, D T
AU  - Ozar DT
AD  - Department of Philosophy, Loyola University Chicago, USA. dozar@luc.edu
LA  - eng
PT  - Journal Article
DEP - 20121130
PL  - Australia
TA  - J Forensic Odontostomatol
JT  - The Journal of forensic odonto-stomatology
JID - 8501421
MH  - Access to Information/ethics
MH  - Advertising/ethics
MH  - Clinical Competence
MH  - Consumer Health Information/ethics
MH  - Decision Making/ethics
MH  - Dental Care/*ethics
MH  - Dentist-Patient Relations/ethics
MH  - Dentistry/*trends
MH  - Dentists/*ethics
MH  - Esthetics, Dental
MH  - Ethics, Business
MH  - *Ethics, Dental
MH  - European Union
MH  - Forecasting
MH  - Humans
MH  - Insurance, Health, Reimbursement/ethics
MH  - Internet/ethics
MH  - Patient Care Planning/ethics
MH  - Practice Management, Dental/ethics
MH  - Professional Competence
MH  - Trust
EDAT- 2012/12/19 06:00
MHDA- 2013/12/18 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/19 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
PST - epublish
SO  - J Forensic Odontostomatol. 2012 Nov 30;30 Suppl 1:72-84.


PMID- 23221263
OWN - NLM
STAT- MEDLINE
DCOM- 20131212
LR  - 20201209
IS  - 2219-6749 (Electronic)
IS  - 0258-414X (Linking)
VI  - 30 Suppl 1
DP  - 2012 Nov 30
TI  - Ethics on the dental treatment of patients with mental disability: results of a
      Netherlands - Belgium survey.
PG  - 21-8
AB  - This study evaluates several ethical dilemmas of by dental practitioners treating
      persons with mental disabilities (PMD) by dentists in the Netherlands and
      Belgium. Ethical dental care for PMD is a hot topic. Worldwide different
      treatment strategies are used in the dental treatment of this patient group. In
      addition, cultural aspect seems to play an important role in the choices made.
      The latter can explain the difficulty in creating European and worldwide
      guidelines on this issue. A questionnaire was sent to dental practitioners
      interested in treating PMD persons both in the Netherlands and in Belgium
      including questions on the use of behaviour management techniques, use and
      attitude towards sedation and physical fixation and the cooperation with other
      health care personal. Behaviour management techniques and sedation are frequently
      used. Dentist of the Netherlands and Belgium in general reject the restraint of
      PMD persons. However, limited use of manual restraint in accordance with the
      carers and the close surrounding of the patient seems to be accepted. Dental
      practitioners are sometimes confronted with an emotional dilemma in treating PMD 
      and the majority feels that it is a continuous challenge to obtain optimal result
      of the dental treatment.
FAU - Marks, Luc
AU  - Marks L
AD  - Centre of Special Care in Dentistry, Ghent University Hospital, Belgium.
      luc.marks@ugent.be
FAU - Adler, Naomi
AU  - Adler N
FAU - Blom-Reukers, Helen
AU  - Blom-Reukers H
FAU - Elhorst, Jan H
AU  - Elhorst JH
FAU - Kraaijenhagen-Oostinga, Annelies
AU  - Kraaijenhagen-Oostinga A
FAU - Vanobbergen, Jacques
AU  - Vanobbergen J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121130
PL  - Australia
TA  - J Forensic Odontostomatol
JT  - The Journal of forensic odonto-stomatology
JID - 8501421
RN  - 0 (Anesthetics, Inhalation)
RN  - K50XQU1029 (Nitrous Oxide)
MH  - Anesthesia, Dental/ethics
MH  - Anesthetics, Inhalation/administration & dosage
MH  - Attitude of Health Personnel
MH  - Behavior Control/ethics
MH  - Belgium
MH  - Caregivers
MH  - Conscious Sedation/ethics
MH  - Cooperative Behavior
MH  - Culture
MH  - Dental Care for Disabled/*ethics
MH  - Dentist-Patient Relations
MH  - Dentists/*ethics/psychology
MH  - *Ethics, Dental
MH  - Female
MH  - Humans
MH  - Hypnosis, Dental
MH  - Interprofessional Relations
MH  - Male
MH  - Netherlands
MH  - Nitrous Oxide/administration & dosage
MH  - *Persons with Mental Disabilities
MH  - Professional-Family Relations
MH  - Restraint, Physical/ethics
EDAT- 2012/12/19 06:00
MHDA- 2013/12/18 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/19 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
PST - epublish
SO  - J Forensic Odontostomatol. 2012 Nov 30;30 Suppl 1:21-8.


PMID- 23221262
OWN - NLM
STAT- MEDLINE
DCOM- 20131212
LR  - 20121211
IS  - 2219-6749 (Electronic)
IS  - 0258-414X (Linking)
VI  - 30 Suppl 1
DP  - 2012 Nov 30
TI  - Personal responsibility in oral health: ethical considerations.
PG  - 12-20
AB  - Personal responsibility is a powerful idea supported by many values central to
      West European thought. On the conceptual level personal responsibility is a
      complex notion. It is important to separate the concept of being responsible for 
      a given state of affairs from the concept of holding people responsible by
      introducing measures that decrease their share of available resources.
      Introducing personal responsibility in oral health also has limitations of a more
      practical nature. Knowledge, social status and other diseases affect the degree
      to which people can be said to be responsible for their poor oral health. These
      factors affect people's oral health and their ability to take care of it. Both
      the conceptual and practical issues at stake are not reasons to abandon the idea 
      of personal responsibility in oral health, but they do affect what the notion
      means and when it is reasonable to hold people responsible. They also commit
      people who support the idea of personal responsibility in oral health to
      supporting the idea of societal responsibility for mitigating the effects of
      factors that diminish people's responsibility and increase the available
      information and knowledge in the population.
FAU - Albertsen, Andreas
AU  - Albertsen A
AD  - Department of Political Science and Government, Aarhus University, Denmark.
      aba@ps.au.dk
LA  - eng
PT  - Journal Article
DEP - 20121130
PL  - Australia
TA  - J Forensic Odontostomatol
JT  - The Journal of forensic odonto-stomatology
JID - 8501421
MH  - Access to Information/ethics
MH  - Attitude to Health
MH  - Choice Behavior/ethics
MH  - *Health Behavior
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Oral Health/*ethics
MH  - Patient Participation
MH  - Personal Autonomy
MH  - Self Care/*ethics
MH  - Social Class
MH  - Social Discrimination/ethics
MH  - Social Justice/ethics
MH  - *Social Responsibility
MH  - Social Values
MH  - Vulnerable Populations
EDAT- 2012/12/19 06:00
MHDA- 2013/12/18 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/19 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
PST - epublish
SO  - J Forensic Odontostomatol. 2012 Nov 30;30 Suppl 1:12-20.


PMID- 23210821
OWN - NLM
STAT- MEDLINE
DCOM- 20130611
LR  - 20121205
IS  - 1746-076X (Electronic)
IS  - 1746-0751 (Linking)
VI  - 7
IP  - 6 Suppl
DP  - 2012 Nov
TI  - Pay-to-participate funding schemes in human cell and tissue clinical studies.
PG  - 105-11
LID - 10.2217/rme.12.75 [doi]
AB  - Funding support for clinical research is traditionally obtained from any of
      several sources, including government agencies, industry, not-for-profit
      foundations, philanthropies and charitable and advocacy organizations. In recent 
      history, there have also been a limited number of cases in which clinical
      research programs were established in which funding was provided directly by
      patients in turn for the ability to participate as nonrandomized subjects. This
      approach to clinical research funding, which I refer to here as the
      'pay-to-participate' model, has been both criticized and rationalized on ethical 
      grounds, with reference to its implications for issues, including equipoise,
      therapeutic misconception, justice, autonomy and risk-benefit balance. Discussion
      of the scientific implications of this funding scheme, however, has been more
      limited. I will briefly review the history of the pay-to-participate model in the
      context of experimental cell and tissue treatments to date and highlight the many
      ethical and, particularly, scientific challenges that unavoidably confound this
      approach to the funding and conduct of clinical research.
FAU - Sipp, Douglas
AU  - Sipp D
AD  - Science Policy and Ethics Studies Unit, RIKEN Center for Developmental Biology,
      2-2-3 Minatojima Minamimachi, Chuo-ku, Kobe, 650-0047, Japan. sipp@cdb.riken
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Regen Med
JT  - Regenerative medicine
JID - 101278116
SB  - IM
MH  - Biomedical Research/*economics/ethics
MH  - Humans
MH  - Patient Participation/*economics
MH  - Reproducibility of Results
MH  - Research Support as Topic/*economics
EDAT- 2012/12/19 06:00
MHDA- 2013/06/12 06:00
CRDT- 2012/12/06 06:00
PHST- 2012/12/06 06:00 [entrez]
PHST- 2012/12/19 06:00 [pubmed]
PHST- 2013/06/12 06:00 [medline]
AID - 10.2217/rme.12.75 [doi]
PST - ppublish
SO  - Regen Med. 2012 Nov;7(6 Suppl):105-11. doi: 10.2217/rme.12.75.


PMID- 23243670
OWN - NLM
STAT- MEDLINE
DCOM- 20130117
LR  - 20191112
IS  - 0807-7096 (Electronic)
IS  - 0029-2001 (Linking)
VI  - 132
IP  - 19
DP  - 2012 Oct 16
TI  - Should genetic findings from genome research be reported back to the
      participants?
PG  - 2190-3
AB  - BACKGROUND: Today, new and powerful sequencing technology is being used in
      biomedical research. In parallel, an intense ethical debate has arisen regarding 
      the handling of the information which is generated through such comprehensive
      analyses. The conflict concerns whether any findings made during research,
      intended or incidental, should be reported back to the individual research
      participant. KNOWLEDGE BASIS: We reviewed international academic literature that 
      has addressed the issue of feedback from genetic studies. The arguments in favour
      and against providing individual information from genome research to research
      participants were reviewed. Key arguments in this debate are presented and
      commented on. RESULTS: A growing number of voices argue in favour of return of
      research-generated genetic information with reference to key values such as
      autonomy, respect, charity, mutuality and reciprocity. The counter-arguments are 
      not as easily accessible, but concern the fundamental distinction between
      research and treatment, which indicates that researchers are not obliged to
      provide individual information to participants. Partly, the counter-arguments
      focus on the possible unfortunate consequences that such feedback may have for
      individuals, research and society as a whole. INTERPRETATION: We are standing at 
      a crossroads with regard to assessing whether returning research-generated
      genetic risk information at the individual level is a moral imperative. Here,
      individually based research ethics run up against concerns of social medicine and
      research-based obligations. The right balance has probably not yet been found.
FAU - Steinsbekk, Kristin Solum
AU  - Steinsbekk KS
AD  - Institutt for samfunnsmedisin, Det medisinske fakultet, Norges
      teknisk-naturvitenskapelige universitet, Norway.
      kristin.steinsbekk@samfunn.ntnu.no
FAU - Solberg, Berge
AU  - Solberg B
LA  - eng
LA  - nor
PT  - Journal Article
PT  - Review
PL  - Norway
TA  - Tidsskr Nor Laegeforen
JT  - Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny
      raekke
JID - 0413423
SB  - IM
MH  - Duty to Recontact/*ethics
MH  - Genetic Predisposition to Disease
MH  - Genetic Research/*ethics
MH  - Genome, Human
MH  - Genomics/ethics
MH  - Humans
MH  - Research Subjects
MH  - Researcher-Subject Relations/ethics
MH  - Sequence Analysis, DNA/ethics
MH  - Truth Disclosure/*ethics
EDAT- 2012/12/18 06:00
MHDA- 2013/01/18 06:00
CRDT- 2012/12/18 06:00
PHST- 2012/12/18 06:00 [entrez]
PHST- 2012/12/18 06:00 [pubmed]
PHST- 2013/01/18 06:00 [medline]
AID - 10.4045/tidsskr.12.0078 [doi]
PST - ppublish
SO  - Tidsskr Nor Laegeforen. 2012 Oct 16;132(19):2190-3. doi: 10.4045/tidsskr.12.0078.


PMID- 23242906
OWN - NLM
STAT- MEDLINE
DCOM- 20130524
LR  - 20220408
IS  - 1715-5258 (Electronic)
IS  - 0008-350X (Linking)
VI  - 58
IP  - 12
DP  - 2012 Dec
TI  - Teaching and evaluation of ethics and professionalism: in Canadian family
      medicine residency programs.
PG  - e751-6
AB  - OBJECTIVE: To document the scope of the teaching and evaluation of ethics and
      professionalism in Canadian family medicine postgraduate training programs, and
      to identify barriers to the teaching and evaluation of ethics and
      professionalism. DESIGN: A survey was developed in collaboration with the
      Committee on Ethics of the College of Family Physicians of Canada. The data are
      reported descriptively and in aggregate. SETTING: Canadian postgraduate family
      medicine training programs. PARTICIPANTS: Between June and December of 2008, all 
      17 Canadian postgraduate family medicine training programs were invited to
      participate. MAIN OUTCOME MEASURES: The first part of the survey explored the
      structure, resources, methods, scheduled hours, and barriers to teaching ethics
      and professionalism. The second section focused on end-of-rotation evaluations,
      other evaluation strategies, and barriers related to the evaluation of ethics and
      professionalism. RESULTS: Eighty-eight percent of programs completed the survey. 
      Most respondents (87%) had learning objectives specifically for ethics and
      professionalism, and 87% had family doctors with training or interest in the area
      leading their efforts. Two-thirds of responding programs had less than 10 hours
      of scheduled instruction per year, and the most common barriers to effective
      teaching were the need for faculty development, competing learning needs, and
      lack of resident interest. Ninety-three percent of respondents assessed ethics
      and professionalism on their end-of-rotation evaluations, with 86% assessing
      specific domains. The most common barriers to evaluation were a lack of suitable 
      tools and a lack of faculty comfort and interest. CONCLUSION: By far most
      Canadian family medicine postgraduate training programs had learning objectives
      and designated faculty leads in ethics and professionalism, yet there was little 
      curricular time dedicated to these areas and a perceived lack of resident
      interest and faculty expertise. Most programs evaluated ethics and
      professionalism as part of their end-of-rotation evaluations, but only a small
      number used novel means of evaluation, and most cited a lack of suitable
      assessment tools as an important barrier.
FAU - Pauls, Merril A
AU  - Pauls MA
AD  - University of Manitoba, Emergency Medicine, GF201-820 Sherbrook St, Winnipeg, MB 
      R3A 1R9. pauls@cc.umanitoba.ca
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Fam Physician
JT  - Canadian family physician Medecin de famille canadien
JID - 0120300
SB  - IM
MH  - Attitude of Health Personnel
MH  - Canada
MH  - Curriculum/*statistics & numerical data
MH  - Education, Medical, Graduate/*methods/organization & administration/statistics & 
      numerical data
MH  - Educational Measurement/methods/*statistics & numerical data
MH  - Ethics, Medical/*education
MH  - Faculty, Medical/organization & administration
MH  - Family Practice/*education/ethics
MH  - Humans
MH  - Internship and Residency/*methods/organization & administration/statistics &
      numerical data
PMC - PMC3520684
EDAT- 2012/12/18 06:00
MHDA- 2013/05/28 06:00
CRDT- 2012/12/18 06:00
PHST- 2012/12/18 06:00 [entrez]
PHST- 2012/12/18 06:00 [pubmed]
PHST- 2013/05/28 06:00 [medline]
AID - 58/12/e751 [pii]
PST - ppublish
SO  - Can Fam Physician. 2012 Dec;58(12):e751-6.


PMID- 23242574
OWN - NLM
STAT- MEDLINE
DCOM- 20140617
LR  - 20211021
IS  - 1863-4362 (Electronic)
IS  - 0021-1265 (Linking)
VI  - 182
IP  - 3
DP  - 2013 Sep
TI  - Career choices of today's medical students: where does surgery rank?
PG  - 337-43
LID - 10.1007/s11845-012-0882-x [doi]
AB  - INTRODUCTION: The national junior doctor recruitment crisis prompts an appraisal 
      of medical student attitudes to different career pathways. The purpose of this
      study was to perform a national review of surgical career intentions of Irish
      final year medical students. METHODS: Ethical and institutional approval was
      obtained at each study location. A questionnaire was designed and distributed to 
      final year students. Domains assessed included demographics, career plans and
      reasons associated. Anonymised responses were collated and evaluated. Categorical
      data were compared with Fisher's exact test. RESULTS: Responses were obtained
      from 342 students in four medical schools of whom 78.6% were undergraduates. Over
      half (53%) were Irish, with Malaysia, Canada and the USA the next most common
      countries of origin. Only 18% of students intended to pursue surgery, with 60%
      stating they did not plan to, and 22% undecided. Of those who plan not to pursue 
      surgery, 28% were unsure about a speciality but the most common choices were
      medicine (39%), general practice (16%) and paediatrics (8%). Reasons for not
      picking a career in surgery included long hours and the unstructured career path.
      Suggestions to improve uptake included earlier and more practical exposure to
      surgery, improved teaching/training and reduction in working hours. CONCLUSIONS: 
      In this study 18% of final year medical students identified surgery as their
      chosen career pathway. Although lifestyle factors are significant in many
      students' decision, perceived quality and duration of surgical training were also
      relevant and are modifiable factors which, if improved could increase interest in
      surgery as a career.
FAU - Boyle, E
AU  - Boyle E
AD  - Graduate Entry Medical School, University of Limerick, Limerick, Ireland.
FAU - Healy, D
AU  - Healy D
FAU - Hill, A D K
AU  - Hill AD
FAU - O'Connell, P R
AU  - O'Connell PR
FAU - Kerin, M
AU  - Kerin M
FAU - McHugh, S
AU  - McHugh S
FAU - Coyle, P
AU  - Coyle P
FAU - Kelly, J
AU  - Kelly J
FAU - Walsh, S R
AU  - Walsh SR
FAU - Coffey, J C
AU  - Coffey JC
LA  - eng
PT  - Journal Article
DEP - 20121215
PL  - Ireland
TA  - Ir J Med Sci
JT  - Irish journal of medical science
JID - 7806864
SB  - IM
MH  - Adult
MH  - Canada
MH  - *Career Choice
MH  - Female
MH  - General Surgery/education/*statistics & numerical data
MH  - Humans
MH  - Male
MH  - Physicians/supply & distribution
MH  - Schools, Medical
MH  - Students, Medical/psychology/*statistics & numerical data
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2012/12/18 06:00
MHDA- 2014/06/18 06:00
CRDT- 2012/12/18 06:00
PHST- 2012/08/01 00:00 [received]
PHST- 2012/11/23 00:00 [accepted]
PHST- 2012/12/18 06:00 [entrez]
PHST- 2012/12/18 06:00 [pubmed]
PHST- 2014/06/18 06:00 [medline]
AID - 10.1007/s11845-012-0882-x [doi]
PST - ppublish
SO  - Ir J Med Sci. 2013 Sep;182(3):337-43. doi: 10.1007/s11845-012-0882-x. Epub 2012
      Dec 15.


PMID- 23242478
OWN - NLM
STAT- MEDLINE
DCOM- 20130910
LR  - 20131121
IS  - 1432-0738 (Electronic)
IS  - 0340-5761 (Linking)
VI  - 87
IP  - 4
DP  - 2013 Apr
TI  - Primary hepatocyte cultures for pharmaco-toxicological studies: at the busy
      crossroad of various anti-dedifferentiation strategies.
PG  - 577-610
LID - 10.1007/s00204-012-0983-3 [doi]
AB  - Continuously increasing understanding of the molecular triggers responsible for
      the onset of diseases, paralleled by an equally dynamic evolution of chemical
      synthesis and screening methods, offers an abundance of pharmacological agents
      with a potential to become new successful drugs. However, before patients can
      benefit of newly developed pharmaceuticals, stringent safety filters need to be
      applied to weed out unfavourable drug candidates. Cost effectiveness and the need
      to identify compound liabilities, without exposing humans to unnecessary risks,
      has stimulated the shift of the safety studies to the earliest stages of drug
      discovery and development. In this regard, in vivo relevant organotypic in vitro 
      models have high potential to revolutionize the preclinical safety testing. They 
      can enable automation of the process, to match the requirements of
      high-throughput screening approaches, while satisfying ethical considerations.
      Cultures of primary hepatocytes became already an inherent part of the
      preclinical pharmaco-toxicological testing battery, yet their routine use,
      particularly for long-term assays, is limited by the progressive deterioration of
      liver-specific features. The availability of suitable hepatic and other
      organ-specific in vitro models is, however, of paramount importance in the light 
      of changing European legal regulations in the field of chemical compounds of
      different origin, which gradually restrict the use of animal studies for safety
      assessment, as currently witnessed in cosmetic industry. Fortunately, research
      groups worldwide spare no effort to establish hepatic in vitro systems. In the
      present review, both classical and innovative methodologies to stabilize the in
      vivo-like hepatocyte phenotype in culture of primary hepatocytes are presented
      and discussed.
FAU - Fraczek, J
AU  - Fraczek J
AD  - Department of Toxicology, Faculty of Medicine and Pharmacy, Centre for
      Pharmaceutical Research, Vrije Universiteit Brussel, Belgium. jfraczek@vub.ac.be
FAU - Bolleyn, J
AU  - Bolleyn J
FAU - Vanhaecke, T
AU  - Vanhaecke T
FAU - Rogiers, V
AU  - Rogiers V
FAU - Vinken, M
AU  - Vinken M
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121215
PL  - Germany
TA  - Arch Toxicol
JT  - Archives of toxicology
JID - 0417615
RN  - 0 (Xenobiotics)
SB  - IM
MH  - Animal Testing Alternatives
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Cell Dedifferentiation/*drug effects
MH  - Cells, Cultured
MH  - Drug Evaluation, Preclinical
MH  - *Drug-Related Side Effects and Adverse Reactions
MH  - Hepatocytes/*drug effects/enzymology/pathology
MH  - Humans
MH  - Mice
MH  - Rats
MH  - Xenobiotics/*toxicity
EDAT- 2012/12/18 06:00
MHDA- 2013/09/11 06:00
CRDT- 2012/12/18 06:00
PHST- 2012/07/10 00:00 [received]
PHST- 2012/11/19 00:00 [accepted]
PHST- 2012/12/18 06:00 [entrez]
PHST- 2012/12/18 06:00 [pubmed]
PHST- 2013/09/11 06:00 [medline]
AID - 10.1007/s00204-012-0983-3 [doi]
PST - ppublish
SO  - Arch Toxicol. 2013 Apr;87(4):577-610. doi: 10.1007/s00204-012-0983-3. Epub 2012
      Dec 15.


PMID- 23242383
OWN - NLM
STAT- MEDLINE
DCOM- 20180430
LR  - 20181202
IS  - 1477-0334 (Electronic)
IS  - 0962-2802 (Linking)
VI  - 25
IP  - 2
DP  - 2016 Apr
TI  - Near efficient target allocations in response-adaptive randomization.
PG  - 807-20
LID - 10.1177/0962280212468378 [doi]
AB  - Traditionally optimal target allocation proportions for response-adaptive designs
      are derived by completely ignoring the actual adaptive randomization procedure.
      Considering efficiency of the allocation designs, we derive near efficient target
      proportions to balance between individual and collective ethics. Performance of
      the derived allocation targets are assessed numerically for binary, normal and
      exponential responses. Generalization for multiple treatments is also addressed.
CI  - (c) The Author(s) 2012.
FAU - Biswas, Atanu
AU  - Biswas A
AD  - Applied Statistics Unit, Indian Statistical Institute, Kolkata, India.
FAU - Bhattacharya, Rahul
AU  - Bhattacharya R
AD  - Department of Statistics, West Bengal State University, Barasat, West Bengal,
      India rahul_bhattya@yahoo.com.
LA  - eng
PT  - Journal Article
DEP - 20121212
PL  - England
TA  - Stat Methods Med Res
JT  - Statistical methods in medical research
JID - 9212457
SB  - IM
MH  - Extracorporeal Membrane Oxygenation
MH  - Humans
MH  - *Random Allocation
MH  - Randomized Controlled Trials as Topic/*methods
MH  - *Research Design
MH  - United Kingdom
OTO - NOTNLM
OT  - *Response-adaptive allocation
OT  - *asymptotically best target
OT  - *efficient allocation design
EDAT- 2012/12/18 06:00
MHDA- 2018/05/01 06:00
CRDT- 2012/12/18 06:00
PHST- 2012/12/18 06:00 [entrez]
PHST- 2012/12/18 06:00 [pubmed]
PHST- 2018/05/01 06:00 [medline]
AID - 0962280212468378 [pii]
AID - 10.1177/0962280212468378 [doi]
PST - ppublish
SO  - Stat Methods Med Res. 2016 Apr;25(2):807-20. doi: 10.1177/0962280212468378. Epub 
      2012 Dec 12.


PMID- 23242247
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130207
LR  - 20220316
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 6
DP  - 2012
TI  - Assessing Preventable Hospitalisation InDicators (APHID): protocol for a
      data-linkage study using cohort study and administrative data.
LID - 10.1136/bmjopen-2012-002344 [doi]
LID - e002344 [pii]
AB  - INTRODUCTION: Potentially preventable hospitalisation (PPH) has been adopted
      widely by international health systems as an indicator of the accessibility and
      overall effectiveness of primary care. The Assessing Preventable Hospitalisation 
      InDicators (APHID) study will validate PPH as a measure of health system
      performance in Australia and Scotland. APHID will be the first large-scale study 
      internationally to explore longitudinal relationships between primary care and
      PPH using detailed person-level information about health risk factors, health
      status and health service use. METHODS AND ANALYSIS: APHID will create a new
      longitudinal data resource by linking together data from a large-scale cohort
      study (the 45 and Up Study) and prospective administrative data relating to use
      of general practitioner (GP) services, dispensing of pharmaceuticals, emergency
      department presentations, hospital admissions and deaths. We will use these
      linked person-level data to explore relationships between frequency, volume,
      nature and costs of primary care services, hospital admissions for PPH diagnoses,
      and health outcomes, and factors that confound and mediate these relationships.
      Using multilevel modelling techniques, we will quantify the contributions of
      person-level, geographic-level and service-level factors to variation in PPH
      rates, including socioeconomic status, country of birth, geographic remoteness,
      physical and mental health status, availability of GP and other services, and
      hospital characteristics. ETHICS AND DISSEMINATION: Participants have consented
      to use of their questionnaire data and to data linkage. Ethical approval has been
      obtained for the study. Dissemination mechanisms include engagement of policy
      stakeholders through a reference group and policy forum, and production of
      summary reports for policy audiences in parallel with the scientific papers from 
      the study.
FAU - Jorm, Louisa R
AU  - Jorm LR
AD  - Centre for Health Research, School of Medicine, University of Western Sydney,
      Campbelltown, New South Wales, Australia.
FAU - Leyland, Alastair H
AU  - Leyland AH
FAU - Blyth, Fiona M
AU  - Blyth FM
FAU - Elliott, Robert F
AU  - Elliott RF
FAU - Douglas, Kirsty M A
AU  - Douglas KM
FAU - Redman, Sally
AU  - Redman S
CN  - HID Investigators
LA  - eng
GR  - MC_U130059823/MRC_/Medical Research Council/United Kingdom
GR  - SPHSU2/CSO_/Chief Scientist Office/United Kingdom
PT  - Journal Article
DEP - 20121212
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3533070
EDAT- 2012/12/18 06:00
MHDA- 2012/12/18 06:01
CRDT- 2012/12/18 06:00
PHST- 2012/12/18 06:00 [entrez]
PHST- 2012/12/18 06:00 [pubmed]
PHST- 2012/12/18 06:01 [medline]
AID - bmjopen-2012-002344 [pii]
AID - 10.1136/bmjopen-2012-002344 [doi]
PST - epublish
SO  - BMJ Open. 2012 Dec 12;2(6). pii: bmjopen-2012-002344. doi:
      10.1136/bmjopen-2012-002344. Print 2012.


PMID- 23242243
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130207
LR  - 20220330
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 6
DP  - 2012
TI  - Protocol for a phase III randomised trial of image-guided intensity modulated
      radiotherapy (IG-IMRT) and conventional radiotherapy for late small bowel
      toxicity reduction after postoperative adjuvant radiation in Ca cervix.
LID - 10.1136/bmjopen-2012-001896 [doi]
LID - e001896 [pii]
AB  - INTRODUCTION: External beam radiation followed by vaginal brachytherapy
      (+/-chemotherapy) leads to reduction in the risk of local recurrence and improves
      progression-free survival in patients with adverse risk factors following
      Wertheim's hysterectomy albeit at the risk of late bowel toxicity. Intensity
      Modulated Radiotherapy (IMRT) results in reduction in bowel doses and has
      potential to reduce late morbidity, however, needs to be confirmed prospectively 
      in a randomised trial. The present randomised trial tests reduction if any in
      late small bowel toxicity with the use of IMRT in postoperative setting. METHODS 
      AND ANALYSIS: Patients more than 18 years of age who need adjuvant (chemo)
      radiation will be eligible. Patients with residual pelvic or para-aortic nodal
      disease, history of multiple abdominal surgeries or any other medical bowel
      condition will be excluded. The trial will randomise patients into standard
      radiation or IMRT. The primary aim is to compare differences in late grades II-IV
      bowel toxicity between the two arms. The secondary aims of the study focus on
      evaluating correlation of dose-volume parameters and late toxicity and quality of
      life. The trial is planned as a multicentre randomised study. The trial is
      designed to detect a 13% difference in late grades II-IV bowel toxicity with an
      alpha of 0.05 and beta of 0.80. A total of 240 patients will be required to
      demonstrate the aforesaid difference. ETHICS AND DISSEMINATION: The trial is
      approved by institutional ethics review board and will be routinely monitored as 
      per standard guidelines. The study results will be disseminated via peer reviewed
      scientific journals, conference presentations and submission to regulatory
      authorities. REGISTRATION: The trial is registered with clinicaltrials.gov (NCT
      01279135).
FAU - Chopra, Supriya
AU  - Chopra S
AD  - Department of Radiation Oncology, ACTREC, Tata Memorial Centre, Navi Mumbai,
      Maharashtra, India.
FAU - Engineer, Reena
AU  - Engineer R
FAU - Mahantshetty, Umesh
AU  - Mahantshetty U
FAU - Misra, Shagun
AU  - Misra S
FAU - Phurailatpam, Reena
AU  - Phurailatpam R
FAU - Paul, Siji N
AU  - Paul SN
FAU - Kannan, Sadhna
AU  - Kannan S
FAU - Kerkar, Rajendra
AU  - Kerkar R
FAU - Maheshwari, Amita
AU  - Maheshwari A
FAU - Shylasree, Ts
AU  - Shylasree Ts
FAU - Ghosh, Jaya
AU  - Ghosh J
FAU - Gupta, Sudeep
AU  - Gupta S
FAU - Thomas, Biji
AU  - Thomas B
FAU - Singh, Shalini
AU  - Singh S
FAU - Sharma, Sanjiv
AU  - Sharma S
FAU - Chilikuri, Srinivas
AU  - Chilikuri S
FAU - Shrivastava, Shyam Kishore
AU  - Shrivastava SK
LA  - eng
PT  - Journal Article
DEP - 20121212
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3533039
EDAT- 2012/12/18 06:00
MHDA- 2012/12/18 06:01
CRDT- 2012/12/18 06:00
PHST- 2012/12/18 06:00 [entrez]
PHST- 2012/12/18 06:00 [pubmed]
PHST- 2012/12/18 06:01 [medline]
AID - bmjopen-2012-001896 [pii]
AID - 10.1136/bmjopen-2012-001896 [doi]
PST - epublish
SO  - BMJ Open. 2012 Dec 12;2(6). pii: bmjopen-2012-001896. doi:
      10.1136/bmjopen-2012-001896. Print 2012.


PMID- 23242239
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130207
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 6
DP  - 2012
TI  - Protocol for the Effective Feedback to Improve Primary Care Prescribing Safety
      (EFIPPS) study: a cluster randomised controlled trial using ePrescribing data.
LID - 10.1136/bmjopen-2012-002359 [doi]
LID - e002359 [pii]
AB  - INTRODUCTION: High-risk prescribing in primary care is common and causes
      considerable harm. Feedback interventions to improve care are attractive because 
      they are relatively cheap to widely implement. There is good evidence that
      feedback has small to moderate effects, but the most recent Cochrane review
      called for more high-quality, large trials that explicitly test different forms
      of feedback. METHODS AND ANALYSIS: The study is a three-arm cluster-randomised
      trial with general practices being randomised and outcomes measured at patient
      level. 262 practices in three Scottish Health Board areas have been randomised
      (94% of all possible practices). The two active arms receive different forms of
      prescribing safety data feedback, with rates of high-risk prescribing compared
      with a 'usual care' arm. Sample size estimation used baseline data from
      participating practices. With 85 practices randomised to each arm, then there is 
      93% power to detect a 25% difference in the percentage of high-risk prescribing
      (from 6.1% to 4.5%) between the usual care arm and each intervention arm. The
      primary outcome is a composite of six high-risk prescribing measures
      (antipsychotic prescribing to people aged >/=75 years; non-steroidal
      anti-inflammatory drug (NSAID) prescribing to people aged >/=75 without
      gastroprotection; NSAID prescribing to people prescribed aspirin/clopidogrel
      without gastroprotection; NSAID prescribing to people prescribed an ACE
      inhibitor/angiotensin receptor blocker and a diuretic; NSAID prescription to
      people prescribed an oral anticoagulant without gastroprotection;
      aspirin/clopidogrel prescription to people prescribed an oral anticoagulant
      without gastroprotection). The primary analysis will use multilevel modelling to 
      account for repeated measurement of outcomes in patients clustered within
      practices. ETHICS AND DISSEMINATION: The study was reviewed and approved by the
      NHS Tayside Committee on Medical Research Ethics B (11/ES/0001). The study will
      be disseminated via a final report to the funder with a publicly available
      research summary, and peer reviewed publications. TRIAL REGISTRATION:
      ClinicalTrials.gov, dossier number NCT01602705.
FAU - Guthrie, Bruce
AU  - Guthrie B
AD  - Population Health Sciences Division, Medical Research Institute, University of
      Dundee, Dundee, UK.
FAU - Treweek, Shaun
AU  - Treweek S
FAU - Petrie, Dennis
AU  - Petrie D
FAU - Barnett, Karen
AU  - Barnett K
FAU - Ritchie, Lewis D
AU  - Ritchie LD
FAU - Robertson, Chris
AU  - Robertson C
FAU - Bennie, Marion
AU  - Bennie M
LA  - eng
SI  - ClinicalTrials.gov/NCT01602705
GR  - CZH/3/17/CSO_/Chief Scientist Office/United Kingdom
GR  - Y01 ES000001/ES/NIEHS NIH HHS/United States
PT  - Journal Article
DEP - 20121213
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3533102
EDAT- 2012/12/18 06:00
MHDA- 2012/12/18 06:01
CRDT- 2012/12/18 06:00
PHST- 2012/12/18 06:00 [entrez]
PHST- 2012/12/18 06:00 [pubmed]
PHST- 2012/12/18 06:01 [medline]
AID - bmjopen-2012-002359 [pii]
AID - 10.1136/bmjopen-2012-002359 [doi]
PST - epublish
SO  - BMJ Open. 2012 Dec 13;2(6). pii: bmjopen-2012-002359. doi:
      10.1136/bmjopen-2012-002359. Print 2012.


PMID- 23241478
OWN - NLM
STAT- MEDLINE
DCOM- 20130311
LR  - 20211021
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 13
DP  - 2012 Dec 16
TI  - Violation of ethical principles in clinical research. Influences and possible
      solutions for Latin America.
PG  - 35
LID - 10.1186/1472-6939-13-35 [doi]
AB  - BACKGROUND: Even though we are now well into the 21st century and notwithstanding
      all the abuse to individuals involved in clinical studies that has been
      documented throughout History, fundamental ethical principles continue to be
      violated in one way or another. DISCUSSION: Here are some of the main factors
      that contribute to the abuse of subjects participating in clinical trials:
      paternalism, improper use of informed consent, lack of strict ethical
      supervision, pressure exerted by health institutions to increase the production
      of scientific material, and the absence of legislation regarding ethics in terms 
      of health care and research. Are researchers ready to respect fundamental ethical
      principles in light of the ample window of information provided by individual
      genomes, while defending the rights of the subjects participating in clinical
      studies as a major priority? SUMMARY: As one of the possible solutions to this
      problem, education regarding fundamental ethical principles is suggested for
      participants in research studies as an initial method of cognitive training in
      ethics, together with the promotion of ethical behavior in order to encourage the
      adoption of reasonable policies in the field of values, attitudes and behavior.
FAU - Cornejo Moreno, Borys Alberto
AU  - Cornejo Moreno BA
AD  - Research Coordinator Medical Associate, Planning and Institutional Liaison
      Coordination, Healthcare Services Management, The Mexican Institute of Social
      Security, Hidalgo Delegation, Delegacion Hidalgo, Pachuca de Soto, CP, Mexico.
      borys.genetics@gmail.com
FAU - Gomez Arteaga, Gress Marissell
AU  - Gomez Arteaga GM
LA  - eng
PT  - Journal Article
DEP - 20121216
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - *Beneficence
MH  - Clinical Trials as Topic/ethics
MH  - *Ethics, Research/education
MH  - Genetic Research/ethics
MH  - Genomics/ethics
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Informed Consent/ethics
MH  - Latin America
MH  - Paternalism/ethics
MH  - *Personal Autonomy
MH  - Research Personnel/ethics
MH  - Research Subjects
MH  - *Social Justice
MH  - *Vulnerable Populations
PMC - PMC3543192
EDAT- 2012/12/18 06:00
MHDA- 2013/03/12 06:00
CRDT- 2012/12/18 06:00
PHST- 2012/11/05 00:00 [received]
PHST- 2012/12/07 00:00 [accepted]
PHST- 2012/12/18 06:00 [entrez]
PHST- 2012/12/18 06:00 [pubmed]
PHST- 2013/03/12 06:00 [medline]
AID - 1472-6939-13-35 [pii]
AID - 10.1186/1472-6939-13-35 [doi]
PST - epublish
SO  - BMC Med Ethics. 2012 Dec 16;13:35. doi: 10.1186/1472-6939-13-35.


PMID- 23241276
OWN - NLM
STAT- MEDLINE
DCOM- 20130522
LR  - 20211021
IS  - 1478-4505 (Electronic)
IS  - 1478-4505 (Linking)
VI  - 10
DP  - 2012 Dec 14
TI  - Current status of health technology reassessment of non-drug technologies: survey
      and key informant interviews.
PG  - 38
LID - 10.1186/1478-4505-10-38 [doi]
AB  - BACKGROUND: Health Technology Reassessment (HTR) is a structured, evidence-based 
      assessment of the clinical, social, ethical and economic effects of a technology 
      currently used in the health care system, to inform optimal use of that
      technology in comparison to its alternatives. Little is known about current
      international HTR practices. The objective of this research was to summarize
      experience-based information gathered from international experts on the
      development, initiation and implementation of a HTR program. METHODS: A mixed
      methods approach, using a survey and in-depth interviews, was adopted. The survey
      covered 8 concepts: prioritization/identification of potentially obsolete
      technologies; program development; implementation; mitigation; program
      championing; stakeholder engagement; monitoring; and reinvestment. Members of
      Health Technology Assessment International (HTAi) and the International Network
      of Agencies for Health Technology Assessment (INAHTA) formed the sampling frame. 
      Participation was solicited via email and the survey was administered online
      using SurveyMonkey. Survey results were analyzed using descriptive statistics. To
      gather more in-depth knowledge, semi-structured interviews were conducted among
      organizations with active HTR programs. Interview questions were developed using 
      the same 8 concepts. The hour-long interviews were recorded, transcribed and
      analyzed using constant comparative analysis. RESULTS: Ninety-five individuals
      responded to the survey: 49 were not discussing HTR, 21 were beginning to discuss
      HTR, nine were imminently developing a program, and 16 participants had programs 
      and were completing reassessments. The survey results revealed that methods vary 
      widely and that although HTR is a powerful tool, it is currently not being used
      to its full potential. Of the 16 with active programs, nine agreed to participate
      in follow-up interviews. Interview participants identified early and extensive
      stakeholder engagement as the most important factors for success. A lack of
      top-down support and financial and human resources are inhibiting program
      development. DISCUSSION: HTR is in its infancy. Although HTRs are being
      conducted, there are no standardized approaches. However, much can be learned
      from current international work. Future work should focus on developing a
      comprehensive methodology, reporting the processes of reassessments and sharing
      successes and challenges in a common platform.
FAU - Leggett, Laura E
AU  - Leggett LE
AD  - Community Health Sciences and the Institute for Public Health, University of
      Calgary, 3280 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada.
FAU - Mackean, Gail
AU  - Mackean G
FAU - Noseworthy, Tom W
AU  - Noseworthy TW
FAU - Sutherland, Lloyd
AU  - Sutherland L
FAU - Clement, Fiona
AU  - Clement F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121214
PL  - England
TA  - Health Res Policy Syst
JT  - Health research policy and systems
JID - 101170481
SB  - IM
MH  - Biomedical Technology/*standards
MH  - Data Collection
MH  - Humans
MH  - Internationality
MH  - Interviews as Topic
MH  - Program Development/economics
MH  - *Technology Assessment, Biomedical
PMC - PMC3542085
EDAT- 2012/12/18 06:00
MHDA- 2013/05/23 06:00
CRDT- 2012/12/18 06:00
PHST- 2012/10/25 00:00 [received]
PHST- 2012/12/10 00:00 [accepted]
PHST- 2012/12/18 06:00 [entrez]
PHST- 2012/12/18 06:00 [pubmed]
PHST- 2013/05/23 06:00 [medline]
AID - 1478-4505-10-38 [pii]
AID - 10.1186/1478-4505-10-38 [doi]
PST - epublish
SO  - Health Res Policy Syst. 2012 Dec 14;10:38. doi: 10.1186/1478-4505-10-38.


PMID- 23241251
OWN - NLM
STAT- MEDLINE
DCOM- 20130402
LR  - 20181202
IS  - 0040-5957 (Print)
IS  - 0040-5957 (Linking)
VI  - 67
IP  - 5
DP  - 2012 Sep-Oct
TI  - Farnesoid X receptor targeting for hepatitis C: study protocol for a
      proof-of-concept trial.
PG  - 423-7
LID - 10.2515/therapie/2012058 [doi]
AB  - OBJECTIVE: To test the modulation of farnesoid X receptor activity on the
      replication of hepatitis C virus in chronically infected patients. METHODS: This 
      is a proof-of-concept trial that was approved by the ex-French Agency for the
      Safety of Health Products (ex-Afssaps [currently ANSM]) and an ethics committee. 
      It has started in January 2010. This one-arm, open-label study examines the
      safety and efficacy of the oral administration of guggulsterone. The main outcome
      measure will be the assessment of blood viral loads. RESULTS: We planned to enrol
      15 genotype 1-infected patients that failed a first-line therapy. CONCLUSION: We 
      think guggulsterone might be an effective therapeutic option for HCV genotype 1
      patients who do not respond well to first-line therapy.
CI  - (c) 2012 Societe Francaise de Pharmacologie et de Therapeutique.
FAU - Scholtes, Caroline
AU  - Scholtes C
AD  - Hospices Civils de Lyon, Hopital de la Croix Rousse, Laboratory of Virology,
      Lyon, France.
FAU - Andre, Patrice
AU  - Andre P
FAU - Trepo, Christian
AU  - Trepo C
FAU - Cornu, Catherine
AU  - Cornu C
FAU - Remontet, Laurent
AU  - Remontet L
FAU - Ecochard, Rene
AU  - Ecochard R
FAU - Bejan-Angoulvant, Theodora
AU  - Bejan-Angoulvant T
FAU - Gueyffier, Francois
AU  - Gueyffier F
LA  - eng
SI  - ClinicalTrials.gov/NCT01492998
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121218
PL  - France
TA  - Therapie
JT  - Therapie
JID - 0420544
RN  - 0 (Antiviral Agents)
RN  - 0 (Pregnenediones)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 0C5V0MRU6P (farnesoid X-activated receptor)
RN  - A4PW148END (pregna-4,17-diene-3,16-dione)
SB  - IM
MH  - Administration, Oral
MH  - Adolescent
MH  - Adult
MH  - Antiviral Agents/administration & dosage/*therapeutic use
MH  - *Clinical Protocols
MH  - Evidence-Based Practice
MH  - Hepatitis C/*drug therapy/virology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Molecular Targeted Therapy/*methods
MH  - Pilot Projects
MH  - Pregnenediones/administration & dosage/therapeutic use
MH  - Receptors, Cytoplasmic and Nuclear/*antagonists & inhibitors
MH  - Salvage Therapy
MH  - Viral Load/drug effects
MH  - Young Adult
EDAT- 2012/12/18 06:00
MHDA- 2013/04/03 06:00
CRDT- 2012/12/18 06:00
PHST- 2012/01/17 00:00 [received]
PHST- 2012/06/01 00:00 [accepted]
PHST- 2012/12/18 06:00 [entrez]
PHST- 2012/12/18 06:00 [pubmed]
PHST- 2013/04/03 06:00 [medline]
AID - 10.2515/therapie/2012058 [doi]
AID - th122043 [pii]
PST - ppublish
SO  - Therapie. 2012 Sep-Oct;67(5):423-7. doi: 10.2515/therapie/2012058. Epub 2012 Dec 
      18.


PMID- 23240872
OWN - NLM
STAT- MEDLINE
DCOM- 20150406
LR  - 20140122
IS  - 1471-6712 (Electronic)
IS  - 0283-9318 (Linking)
VI  - 28
IP  - 1
DP  - 2014 Mar
TI  - Development of an assessment tool for the multidisciplinary evaluation of
      neurological dependency: preliminary findings.
PG  - 193-203
LID - 10.1111/scs.12018 [doi]
AB  - BACKGROUND: Multidisciplinary inputs are of vital importance in the comprehensive
      care management and rehabilitation of individuals with long-term neurological
      conditions. Although many ordinal measures of disability correlate with patient
      dependency and care, few are based on numbers of different health professionals
      required, or their skill-mix, for assistance associated with levels of
      dependency. AIM AND OBJECTIVES: To develop an instrument to assess dependency in 
      adult patients suffering from severe and complex neurological disability for use 
      by multidisciplinary teams. Objectives were to establish content validity,
      construct validity, inter-rater reliability and internal consistency, and to
      demonstrate preliminary clinical utility from the perspective of professional
      staff. DESIGN AND METHODS: A mixed methods design utilised qualitative and
      quantitative approaches. Stage I involved developmental fieldwork using focus
      groups (n = 3), questionnaires (n = 70), expert panel (n = 20) and direct
      observation (n = 12). In stage 2, intensive refinement through direct
      observation, construct validity and reliability testing (n = 100) of the
      instrument was completed. The research complied with the research governance and 
      ethical standards set by the Department of Health (UK). RESULTS: In the final
      format, an instrument was developed which comprised two sections. Section 1: an
      ordinal scaled basic care section, with 15 categories of dependency and level of 
      descriptors based on numbers, grade and time taken by staff providing assistance.
      Factor analysis identified one dominant and four subsidiary factors which
      explained 67% of the total variance. Overall inter-rater agreement was 0.87
      (kappa coefficient: range 0.67-1.0), and Cronbach's coefficient alpha was 0.733. 
      Section 2: comprised a nominally measured specialist care section for inputs from
      nurses and therapists. The mean time taken to complete assessments was 12
      minutes. CONCLUSION: The instrument satisfied preliminary selective criteria for 
      validity and reliability. Further research is necessary to satisfy other
      requirements of psychometric testing and clinical utility.
CI  - (c) 2012 The Authors Scandinavian Journal of Caring Sciences (c) 2012 Nordic
      College of Caring Science.
FAU - Pierce, Elaine
AU  - Pierce E
AD  - Institute for Leadership and Service Improvement, V-612, Faculty of Health and
      Social Care, London South Bank University, London, SE1 0AA, UK.
FAU - McLaren, Susan
AU  - McLaren S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121213
PL  - Sweden
TA  - Scand J Caring Sci
JT  - Scandinavian journal of caring sciences
JID - 8804206
MH  - Adult
MH  - Humans
MH  - Nervous System Diseases/*diagnosis/physiopathology
MH  - *Physical Examination
MH  - Reproducibility of Results
OTO - NOTNLM
OT  - assessment instrument
OT  - construct validity
OT  - mixed methods research
OT  - multidisciplinary team
OT  - neurological dependency
OT  - rehabilitation
OT  - severe and complex disability
OT  - tool development
EDAT- 2012/12/18 06:00
MHDA- 2015/04/07 06:00
CRDT- 2012/12/18 06:00
PHST- 2012/08/02 00:00 [received]
PHST- 2012/10/27 00:00 [accepted]
PHST- 2012/12/18 06:00 [entrez]
PHST- 2012/12/18 06:00 [pubmed]
PHST- 2015/04/07 06:00 [medline]
AID - 10.1111/scs.12018 [doi]
PST - ppublish
SO  - Scand J Caring Sci. 2014 Mar;28(1):193-203. doi: 10.1111/scs.12018. Epub 2012 Dec
      13.


PMID- 23240871
OWN - NLM
STAT- MEDLINE
DCOM- 20130624
LR  - 20220330
IS  - 1445-6354 (Electronic)
IS  - 1445-6354 (Linking)
VI  - 12
DP  - 2012
TI  - Continuing education training focused on the development of behavioral telehealth
      competencies in behavioral healthcare providers.
PG  - 2108
AB  - INTRODUCTION: Telehealth allows behavioral health care and specialty services to 
      be extended to rural residents. Telehealth is an important resource for the
      Alaskan healthcare system, which is tasked with providing services to culturally 
      diverse populations living in remote areas. Training competent providers to
      deliver telehealth services is vital for the implementation of successful
      telehealth programs. Yet, the literature is lacking in the area of provider
      behavioral telehealth competency training. METHODS: This study assessed the
      impact of a Behavioral Telehealth Ethical Competencies Training program on 16
      behavioral health providers' development of behavioral telehealth competency. A
      total of 14 competencies were developed, which required participants to
      understand the roles and responsibilities of a behavioral telehealth coordinator 
      working at the distal site as well as the roles and responsibilities of the
      therapist. Video vignettes evaluating the 14 competencies, self-reported
      competence surveys and follow-up surveys of progress on telehealth goals were
      utilized to assess effects of the training. RESULTS: Results indicated
      participants' behavioral telehealth competencies increased following training.
      Participants reported positive perceptions regarding their competency, and
      achieved progress on the majority of behavioral telehealth goals set during the
      training. CONCLUSIONS: This study provides a baseline for developing a best
      practice model for behavioral telehealth service delivery by identifying specific
      provider competencies for administering effective behavioral telehealth services.
      A unique continuing education training model, led by content experts including
      university professors and Alaska Native Elders, incorporating behavioral
      telehealth, rural ethics, cultural competency and vicarious trauma training is
      described. Lastly, this study details the use of an innovative video vignette
      assessment instrument for evaluating the effectiveness of continuing education
      training.
FAU - Gifford, V
AU  - Gifford V
AD  - Psychology Department, University of Alaska Fairbanks, Fairbanks, Alaska, USA.
      vmgifford@alaska.edu
FAU - Niles, B
AU  - Niles B
FAU - Rivkin, I
AU  - Rivkin I
FAU - Koverola, C
AU  - Koverola C
FAU - Polaha, J
AU  - Polaha J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20121217
PL  - Australia
TA  - Rural Remote Health
JT  - Rural and remote health
JID - 101174860
SB  - IM
MH  - Alaska
MH  - Clinical Competence/*standards/statistics & numerical data
MH  - Cultural Competency/ethics
MH  - Education, Continuing/*methods
MH  - Educational Measurement
MH  - Female
MH  - Follow-Up Studies
MH  - Health Personnel/*psychology/statistics & numerical data
MH  - Health Services Accessibility
MH  - Humans
MH  - Male
MH  - Mental Health/*education
MH  - Professional Role
MH  - Professional-Patient Relations/ethics
MH  - Program Development
MH  - Resilience, Psychological
MH  - *Rural Health Services/ethics/standards
MH  - Self Report
MH  - Specialization
MH  - Staff Development
MH  - Surveys and Questionnaires
MH  - Telemedicine/*ethics
MH  - Workforce
EDAT- 2012/12/18 06:00
MHDA- 2013/06/26 06:00
CRDT- 2012/12/18 06:00
PHST- 2012/12/18 06:00 [entrez]
PHST- 2012/12/18 06:00 [pubmed]
PHST- 2013/06/26 06:00 [medline]
AID - 2108 [pii]
PST - ppublish
SO  - Rural Remote Health. 2012;12:2108. Epub 2012 Dec 17.


PMID- 23240452
OWN - NLM
STAT- MEDLINE
DCOM- 20130102
LR  - 20121217
IS  - 1899-5276 (Print)
IS  - 1899-5276 (Linking)
VI  - 21
IP  - 4
DP  - 2012 Jul-Aug
TI  - Can we predict urinary stone composition based on an analysis of microelement
      concentration in the hair and urine?
PG  - 469-75
AB  - BACKGROUND: In recent years the role of trace elements in lithogenesis has
      received steadily increasing attention. OBJECTIVES: This study was aimed to
      attempt to find the correlations between the chemical content of the stones and
      the concentration of chosen elements in the urine and hair of stone formers.
      MATERIAL AND METHODS: The proposal for the study was approved by the local ethics
      committee. Specimens were taken from 219 consecutive stone-formers. The content
      of the stone was evaluated using atomic absorption spectrometry,
      spectrophotometry, and colorimetric methods. An analysis of 29 elements in hair
      and 21 elements in urine was performed using inductively coupled plasma-atomic
      emission spectrometry. RESULTS: Only a few correlations between the composition
      of stones and the distribution of elements in urine and in hair were found. All
      were considered incidental. CONCLUSIONS: The data obtained did not allow for the 
      creation of a proper and practical algorithm to predict stone chemical
      composition based on hair and urine analysis.
FAU - Slojewski, Marcin
AU  - Slojewski M
AD  - Department of Urology and Urological Oncology, Pomeranian Medical University,
      Szczecin, Poland. mslojewski@csv.pl
FAU - Safranow, Krzysztof
AU  - Safranow K
FAU - Jakubowska, Katarzyna
AU  - Jakubowska K
FAU - Olszewska, Maria
AU  - Olszewska M
FAU - Pawlik, Andrzej
AU  - Pawlik A
FAU - Juzyszyn, Zygmunt
AU  - Juzyszyn Z
FAU - Drozdzik, Marek
AU  - Drozdzik M
FAU - Chlubek, Dariusz
AU  - Chlubek D
FAU - Hammerer, Peter
AU  - Hammerer P
FAU - Sikorski, Andrzej
AU  - Sikorski A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Poland
TA  - Adv Clin Exp Med
JT  - Advances in clinical and experimental medicine : official organ Wroclaw Medical
      University
JID - 101138582
RN  - 0 (Trace Elements)
SB  - IM
MH  - Adult
MH  - Hair/*chemistry
MH  - Humans
MH  - Middle Aged
MH  - Spectrophotometry/methods
MH  - Trace Elements/*analysis
MH  - Urinary Calculi/*chemistry
MH  - Urine/*chemistry
EDAT- 2012/12/18 06:00
MHDA- 2013/01/03 06:00
CRDT- 2012/12/18 06:00
PHST- 2012/12/18 06:00 [entrez]
PHST- 2012/12/18 06:00 [pubmed]
PHST- 2013/01/03 06:00 [medline]
PST - ppublish
SO  - Adv Clin Exp Med. 2012 Jul-Aug;21(4):469-75.


PMID- 23240288
OWN - NLM
STAT- MEDLINE
DCOM- 20130104
LR  - 20121217
IS  - 0332-3102 (Print)
IS  - 0332-3102 (Linking)
VI  - 105
IP  - 9
DP  - 2012 Oct
TI  - Ageism and clinical research.
PG  - 311-2
AB  - Despite being the most significant consumers of health care resources and
      medications worldwide, recent international research has highlighted the
      under-representation of older participants from clinical trials. This creates
      problems for physicians as the patients seen in clinical practice are not
      representative of those on which medical treatments and interventions have been
      trialled, and we need to consider whether results (both negative and positive)
      from these trials are applicable to these patients. Our aim was to gauge whether 
      exclusion of older people was prevalent in research proposals submitted to Dublin
      teaching hospitals. We audited all clinical research proposals submitted to the
      Research Ethics committee (REC) covering the teaching hospitals attached to
      Trinity College Dublin (TCD) from July 2008 to July 2011 inclusive, recording
      exclusion of patients based on an arbitrary upper age limit. Of the 226 relevant 
      trials studied, 31(13.7%) excluded participants based solely on an arbitrary
      upper age limit. 22 (9.8%) of the relevant trials were submitted by
      geriatricians, none of which excluded patients based solely on age. Over 50% (12 
      of 22) trials submitted by neurology/psychiatry excluded patients based on an
      upper age limit. The mean upper age limit used over all trials as a cut-off was
      69.2 years of age. As well as this, the majority of the remaining trials also
      contained other exclusion criteria, especially those based on cognitive function 
      which further limited participation of older people. While we found that a
      significant proportion of clinical trials submitted to the TCD REC still excluded
      patients based arbitrarily on an upper age limit, participation rates of older
      people seem to be higher in this Irish centre than that seen in international
      trials. Significant room for improvement still remains however and there needs to
      be a promotion of greater awareness of the need for developing, testing and
      licensing medicines so that it mirrors the consumer groups in which they will be 
      used. Increased input from geriatricians around the testing and licensing of
      medicines, and in licensing agencies, would greatly help in this regard. It is
      both unhelpful for optimal healthcare as well as fundamentally unjust to exclude 
      participants from clinical research based solely on an arbitrary age limit.
FAU - Briggs, R
AU  - Briggs R
AD  - Centre for Ageing, Neuroscience and the Humanities, Tallaght Hospital, Dublin.
FAU - Robinson, S
AU  - Robinson S
FAU - O'Neill, D
AU  - O'Neill D
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Ir Med J
JT  - Irish medical journal
JID - 0430275
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Ageism/*statistics & numerical data
MH  - Biomedical Research
MH  - Clinical Trials as Topic/methods/*statistics & numerical data
MH  - Female
MH  - Geriatric Assessment/methods/*statistics & numerical data
MH  - Geriatrics/organization & administration
MH  - *Health Status
MH  - Humans
MH  - Ireland
MH  - Male
MH  - Middle Aged
MH  - *Patient Selection
MH  - Research Design
EDAT- 2012/12/18 06:00
MHDA- 2013/01/05 06:00
CRDT- 2012/12/18 06:00
PHST- 2012/12/18 06:00 [entrez]
PHST- 2012/12/18 06:00 [pubmed]
PHST- 2013/01/05 06:00 [medline]
PST - ppublish
SO  - Ir Med J. 2012 Oct;105(9):311-2.


PMID- 23240233
OWN - NLM
STAT- MEDLINE
DCOM- 20130115
LR  - 20121217
IS  - 0300-9041 (Print)
IS  - 0300-9041 (Linking)
VI  - 80
IP  - 10
DP  - 2012 Oct
TI  - [Code of ethics for professional practice of the Colegio Mexicano de Medicos
      Especialistas en Ginecologia y Obstetricia].
PG  - 673-7
FAU - Weingerz Mehl, Samuel
AU  - Weingerz Mehl S
AD  - Colegio Mexicano de Especialistas en Ginecologia y Obstetricia.
FAU - Haghenbeck Altamirano, Javier
AU  - Haghenbeck Altamirano J
FAU - Godoy Morales, Hector
AU  - Godoy Morales H
FAU - Ruiz Moreno, Jose Antonio
AU  - Ruiz Moreno JA
CN  - Colegio Mexicano de Especialistas en Ginecologia y Obstetricia
LA  - spa
PT  - Guideline
PT  - Journal Article
TT  - Codigo de etica para el ejercicio profesional del Colegio Mexicano de
      Especialistas en Ginecologia y Obstetricia.
PL  - Mexico
TA  - Ginecol Obstet Mex
JT  - Ginecologia y obstetricia de Mexico
JID - 0376552
SB  - IM
MH  - *Codes of Ethics
MH  - Female
MH  - Gynecology/*ethics/standards
MH  - Humans
MH  - Interprofessional Relations/ethics
MH  - Mexico
MH  - Obstetrics/*ethics/standards
MH  - Physician-Patient Relations/ethics
MH  - Pregnancy
MH  - Professional Practice/ethics/standards
MH  - Societies, Medical/*ethics
EDAT- 2012/12/18 06:00
MHDA- 2013/01/16 06:00
CRDT- 2012/12/18 06:00
PHST- 2012/12/18 06:00 [entrez]
PHST- 2012/12/18 06:00 [pubmed]
PHST- 2013/01/16 06:00 [medline]
PST - ppublish
SO  - Ginecol Obstet Mex. 2012 Oct;80(10):673-7.


PMID- 23239910
OWN - NLM
STAT- MEDLINE
DCOM- 20131231
LR  - 20211021
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Linking)
VI  - 18
IP  - 46
DP  - 2012 Dec 14
TI  - Adult to adult living related liver transplantation: where do we currently stand?
PG  - 6729-36
LID - 10.3748/wjg.v18.i46.6729 [doi]
AB  - Adult to adult living donor liver transplantation (AALDLT) was first preformed in
      the United States in 1997. The procedure was rapidly integrated into clinical
      practice, but in 2002, possibly due to the first widely publicized donor death,
      the number of living liver donors plummeted. The number of donors has since
      reached a steady plateau far below its initial peak. In this review we evaluate
      the current climate of AALDLT. Specifically, we focus on several issues key to
      the success of AALDLT: determining the optimal indications for AALDLT, balancing 
      graft size and donor safety, assuring adequate outflow, minimizing biliary
      complications, and maintaining ethical practices. We conclude by offering
      suggestions for the future of AALDLT in United States transplantation centers.
FAU - Carlisle, Erica M
AU  - Carlisle EM
AD  - Department of Surgery, Baylor University Medical Center, Dallas, TX 75246, USA.
FAU - Testa, Giuliano
AU  - Testa G
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
SB  - IM
MH  - Adult
MH  - Ethics, Medical
MH  - Humans
MH  - Liver Failure/therapy
MH  - Liver Transplantation/*methods/*trends
MH  - *Living Donors
MH  - Organ Size
MH  - Patient Safety
MH  - Tissue and Organ Procurement/*methods/*trends
MH  - Treatment Outcome
MH  - United States
PMC - PMC3520161
OTO - NOTNLM
OT  - Adult to adult living donor liver transplantation
OT  - Biliary complications
OT  - Ethics
OT  - Graft size
OT  - Liver failure
OT  - Outflow
EDAT- 2012/12/15 06:00
MHDA- 2014/01/01 06:00
CRDT- 2012/12/15 06:00
PHST- 2012/04/18 00:00 [received]
PHST- 2012/08/03 00:00 [revised]
PHST- 2012/08/14 00:00 [accepted]
PHST- 2012/12/15 06:00 [entrez]
PHST- 2012/12/15 06:00 [pubmed]
PHST- 2014/01/01 06:00 [medline]
AID - 10.3748/wjg.v18.i46.6729 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2012 Dec 14;18(46):6729-36. doi: 10.3748/wjg.v18.i46.6729.


PMID- 23239742
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20220408
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 11
DP  - 2013 Nov
TI  - The potential benefit of the placebo effect in sham-controlled trials:
      implications for risk-benefit assessments and informed consent.
PG  - 703-7
LID - 10.1136/medethics-2012-101045 [doi]
AB  - There has been considerable debate surrounding the ethics of sham-controlled
      trials of procedures and interventions. Critics argue that these trials are
      unethical because participants assigned to the control group have no prospect of 
      benefit from the trial, yet they are exposed to all the risks of the sham
      intervention. However, the placebo effect associated with sham procedures can
      often be substantial and has been well documented in the scientific literature.
      We argue that, in light of the scientific evidence supporting the benefits of
      sham interventions for pain and Parkinson's disease that stem from the placebo
      effect, these sham-controlled trials should be considered as offering potential
      direct benefit to participants. If scientific evidence demonstrates the positive 
      effect of placebo from sham interventions on other conditions, sham-controlled
      trials of interventions for the treatment of these conditions should be
      considered to have prospects of benefit as well. This potential benefit should be
      taken into account by research ethics committees in risk-benefit analyses, and be
      included in informed consent documents.
FAU - Brim, Remy L
AU  - Brim RL
AD  - Department of Bioethics, National Institutes of Health, , Bethesda, Maryland,
      USA.
FAU - Miller, Franklin G
AU  - Miller FG
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
DEP - 20121213
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Consent Forms
MH  - Controlled Clinical Trials as Topic/*ethics
MH  - Ethics Committees, Research/ethics
MH  - Ethics, Research
MH  - Humans
MH  - Informed Consent/*ethics
MH  - *Placebo Effect
MH  - Risk Assessment/ethics/standards
PMC - PMC3812890
OTO - NOTNLM
OT  - Informed Consent
OT  - Policy Guidelines/Inst. Review Boards/Review Cttes.
OT  - Research Ethics
EDAT- 2012/12/15 06:00
MHDA- 2015/03/31 06:00
CRDT- 2012/12/15 06:00
PHST- 2012/12/15 06:00 [entrez]
PHST- 2012/12/15 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
AID - medethics-2012-101045 [pii]
AID - 10.1136/medethics-2012-101045 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Nov;39(11):703-7. doi: 10.1136/medethics-2012-101045. Epub
      2012 Dec 13.


PMID- 23239082
OWN - NLM
STAT- MEDLINE
DCOM- 20140318
LR  - 20130605
IS  - 1099-1751 (Electronic)
IS  - 0749-6753 (Linking)
VI  - 28
IP  - 2
DP  - 2013 Apr-Jun
TI  - Informal patient payments in maternity hospitals in Kiev, Ukraine.
PG  - e169-87
LID - 10.1002/hpm.2155 [doi]
AB  - Maternity care in Ukraine is a government priority. However, it has not undergone
      substantial changes since the collapse of the Soviet Union. Similar to the entire
      health care sector in Ukraine, maternity care suffers from inefficient funding,
      which results in low quality and poor access to services. The objective of this
      paper is to explore the practice of informal payments for maternity care in
      Ukraine, specifically in cases of childbirth in Kiev maternity hospitals. The
      paper provides an ethnographic study on the consumers' and providers' experiences
      with informal payments. The results suggest that informal payments for childbirth
      are an established practice in Kiev maternity hospitals. The bargaining process
      between the pregnant woman (incl. her partner) and the obstetrician is an
      important part of the predelivery arrangement, including the informal payment. To
      deal with informal payments in Kiev maternity hospitals, there is a need for the 
      following: (i) regulation of the "quasi-official" patient payments at the health 
      care facility level; and (ii) improvement of professional ethics through staff
      training. These strategies should be coupled with improved governance of the
      health care sector in general, and maternity care in particular in order to
      attain international quality standards and adequate access to facilities.
CI  - Copyright (c) 2012 John Wiley & Sons, Ltd.
FAU - Stepurko, Tetiana
AU  - Stepurko T
AD  - School of Public Health, National University of Kyiv-Mohyla Academy, Kiev,
      Ukraine. t.stepurko@maastrichtuniversity.nl
FAU - Pavlova, Milena
AU  - Pavlova M
FAU - Levenets, Olena
AU  - Levenets O
FAU - Gryga, Irena
AU  - Gryga I
FAU - Groot, Wim
AU  - Groot W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121213
PL  - England
TA  - Int J Health Plann Manage
JT  - The International journal of health planning and management
JID - 8605825
MH  - Anthropology, Cultural
MH  - Female
MH  - Financing, Personal
MH  - *Health Services Accessibility
MH  - *Hospitals, Maternity
MH  - Humans
MH  - Male
MH  - Medical Staff, Hospital/*economics/psychology
MH  - *Negotiating
MH  - Patient Credit and Collection/*economics/*methods
MH  - Physician-Patient Relations
MH  - Pregnancy
MH  - Qualitative Research
MH  - Quality Indicators, Health Care
MH  - Ukraine
EDAT- 2012/12/15 06:00
MHDA- 2014/03/19 06:00
CRDT- 2012/12/15 06:00
PHST- 2012/02/15 00:00 [received]
PHST- 2012/11/07 00:00 [revised]
PHST- 2012/11/07 00:00 [accepted]
PHST- 2012/12/15 06:00 [entrez]
PHST- 2012/12/15 06:00 [pubmed]
PHST- 2014/03/19 06:00 [medline]
AID - 10.1002/hpm.2155 [doi]
PST - ppublish
SO  - Int J Health Plann Manage. 2013 Apr-Jun;28(2):e169-87. doi: 10.1002/hpm.2155.
      Epub 2012 Dec 13.


PMID- 23238539
OWN - NLM
STAT- MEDLINE
DCOM- 20130129
LR  - 20121214
IS  - 0231-424X (Print)
IS  - 0231-424X (Linking)
VI  - 99
IP  - 4
DP  - 2012 Dec
TI  - Overview of large animal myocardial infarction models (review).
PG  - 365-81
LID - 10.1556/APhysiol.99.2012.4.1 [doi]
AB  - There are several experimental models for the in vivo investigation of myocardial
      infarction (MI) in small (mouse, rat) and large animals (dog, pig, sheep and
      baboons). The application of large animal models raises ethical concerns, the
      design of experiments needs longer follow-up times, requiring proper breeding and
      housing conditions, therefore resulting in higher cost, than in vitro or small
      animal studies. On the other hand, the relevance of large animal models is very
      important, since they mostly resemble to human physiological and
      pathophysiological processes. The first main difference among MI models is the
      method of induction (open or closed chest, e.g. surgical or catheter based); the 
      second main difference is the presence or absence of reperfusion. The former
      (i.e. reperfused MI) allows the investigation of reperfusion injury and new
      catheter based techniques during percutaneous coronary interventions, while the
      latter (i.e. nonreperfused MI) serves as a traditional coronary occlusion model, 
      to test the effects of new pharmacological agents and biological therapies, as
      cell therapy. The reperfused and nonreperfused myocardial infarction has
      different outcomes, regarding left ventricular function, remodelling, subsequent 
      heart failure, aneurysm formation and mortality. Our aim was to review the
      literature and report our findings regarding experimental MI models, regarding
      the differences among species, methods, reproducibility and interpretation.
FAU - Lukacs, E
AU  - Lukacs E
AD  - University of Pecs Heart Institute, Medical School Pecs Hungary.
FAU - Magyari, B
AU  - Magyari B
FAU - Toth, L
AU  - Toth L
FAU - Petrasi, Zs
AU  - Petrasi Z
FAU - Repa, I
AU  - Repa I
FAU - Koller, A
AU  - Koller A
FAU - Horvath, Ivan
AU  - Horvath I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Hungary
TA  - Acta Physiol Hung
JT  - Acta physiologica Hungarica
JID - 8309201
SB  - IM
MH  - Animals
MH  - *Body Size
MH  - *Disease Models, Animal
MH  - Humans
MH  - Myocardial Infarction/*physiopathology/*therapy
EDAT- 2012/12/15 06:00
MHDA- 2013/01/30 06:00
CRDT- 2012/12/15 06:00
PHST- 2012/12/15 06:00 [entrez]
PHST- 2012/12/15 06:00 [pubmed]
PHST- 2013/01/30 06:00 [medline]
AID - JT6J547T98237185 [pii]
AID - 10.1556/APhysiol.99.2012.4.1 [doi]
PST - ppublish
SO  - Acta Physiol Hung. 2012 Dec;99(4):365-81. doi: 10.1556/APhysiol.99.2012.4.1.


PMID- 23238157
OWN - NLM
STAT- MEDLINE
DCOM- 20130415
LR  - 20220316
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 266
IP  - 3
DP  - 2013 Mar
TI  - Influence of the choice of software package on the outcome of semiquantitative MR
      myocardial perfusion analysis.
PG  - 759-65
LID - 10.1148/radiol.12120626 [doi]
AB  - PURPOSE: To assess the repeatability and reproducibility of semiquantitative
      magnetic resonance (MR) perfusion analysis performed by using different software 
      packages. MATERIALS AND METHODS: The study protocol was approved by the
      institutional ethics committee. Informed consent was obtained from each patient. 
      Semiquantitative perfusion analysis was performed twice by two independent
      observers using four dedicated software packages. MR perfusion datasets
      originated from eight patients with known single-vessel disease who were
      scheduled for percutaneous coronary intervention (PCI) on the basis of coronary
      angiography findings. Each patient underwent two examinations: 1 day before and 1
      day after PCI. Repeatability (intra- and interobserver agreements) and
      reproducibility (intersoftware agreement) were evaluated for perfusion upslope
      and myocardial perfusion reserve index with Student t test and Bland-Altman
      analyses. RESULTS: Intra- and interobserver agreements were good and comparable
      for repeated measurements within each individual software platform (mean
      differences < 6%, intraclass correlation coefficient [ICC] >/= 0.68). However,
      the intersoftware variability was significant (limits of agreement >/= 65%, ICC
      </= 0.67) such that the values produced with the different software packages are 
      not interchangeable. CONCLUSION: The results indicate high repeatability within
      individual software but low reproducibility between different software packages, 
      suggesting that within-group and/or sequential observation of semiquantitative
      perfusion parameters must be performed with the same software platform. Before
      semiquantitative perfusion analysis can be incorporated reliably into clinical
      studies, it is important to resolve the differences between the software
      packages.
FAU - Handayani, Astri
AU  - Handayani A
AD  - Center for Medical Imaging North East Netherlands, University of Groningen, and
      Department of Radiology, University Medical Center, Hanzeplein 1, Groningen 9713 
      GZ, The Netherlands. a.handayani@umcg.nl
FAU - Sijens, Paul E
AU  - Sijens PE
FAU - Lubbers, Daniel D
AU  - Lubbers DD
FAU - Triadyaksa, Pandji
AU  - Triadyaksa P
FAU - Oudkerk, Matthys
AU  - Oudkerk M
FAU - van Ooijen, Peter M A
AU  - van Ooijen PM
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
DEP - 20121213
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Aged
MH  - *Algorithms
MH  - Coronary Artery Disease/*diagnostic imaging
MH  - Female
MH  - Humans
MH  - Image Enhancement/methods
MH  - Image Interpretation, Computer-Assisted/*methods
MH  - Magnetic Resonance Angiography/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardial Perfusion Imaging/*methods
MH  - Pattern Recognition, Automated/*methods
MH  - Radiography
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - *Software
MH  - Software Validation
EDAT- 2012/12/15 06:00
MHDA- 2013/04/16 06:00
CRDT- 2012/12/15 06:00
PHST- 2012/12/15 06:00 [entrez]
PHST- 2012/12/15 06:00 [pubmed]
PHST- 2013/04/16 06:00 [medline]
AID - radiol.12120626 [pii]
AID - 10.1148/radiol.12120626 [doi]
PST - ppublish
SO  - Radiology. 2013 Mar;266(3):759-65. doi: 10.1148/radiol.12120626. Epub 2012 Dec
      13.


PMID- 23237631
OWN - NLM
STAT- MEDLINE
DCOM- 20130711
LR  - 20211021
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 13
DP  - 2012 Dec 13
TI  - Efficiency and effectiveness of the use of an acenocoumarol pharmacogenetic
      dosing algorithm versus usual care in patients with venous thromboembolic disease
      initiating oral anticoagulation: study protocol for a randomized controlled
      trial.
PG  - 239
LID - 10.1186/1745-6215-13-239 [doi]
AB  - BACKGROUND: Hemorrhagic events are frequent in patients on treatment with
      antivitamin-K oral anticoagulants due to their narrow therapeutic margin. Studies
      performed with acenocoumarol have shown the relationship between demographic,
      clinical and genotypic variants and the response to these drugs. Once the
      influence of these genetic and clinical factors on the dose of acenocoumarol
      needed to maintain a stable international normalized ratio (INR) has been
      demonstrated, new strategies need to be developed to predict the appropriate
      doses of this drug. Several pharmacogenetic algorithms have been developed for
      warfarin, but only three have been developed for acenocoumarol. After the
      development of a pharmacogenetic algorithm, the obvious next step is to
      demonstrate its effectiveness and utility by means of a randomized controlled
      trial. The aim of this study is to evaluate the effectiveness and efficiency of
      an acenocoumarol dosing algorithm developed by our group which includes
      demographic, clinical and pharmacogenetic variables (VKORC1, CYP2C9, CYP4F2 and
      ApoE) in patients with venous thromboembolism (VTE). METHODS AND DESIGN: This is 
      a multicenter, single blind, randomized controlled clinical trial. The protocol
      has been approved by La Paz University Hospital Research Ethics Committee and by 
      the Spanish Drug Agency. Two hundred and forty patients with VTE in which oral
      anticoagulant therapy is indicated will be included. Randomization (case/control 
      1:1) will be stratified by center. Acenocoumarol dose in the control group will
      be scheduled and adjusted following common clinical practice; in the experimental
      arm dosing will be following an individualized algorithm developed and validated 
      by our group. Patients will be followed for three months. The main endpoints are:
      1) Percentage of patients with INR within the therapeutic range on day seven
      after initiation of oral anticoagulant therapy; 2) Time from the start of oral
      anticoagulant treatment to achievement of a stable INR within the therapeutic
      range; 3) Number of INR determinations within the therapeutic range in the first 
      six weeks of treatment. DISCUSSION: To date, there are no clinical trials
      comparing pharmacogenetic acenocoumarol dosing algorithm versus routine clinical 
      practice in VTE. Implementation of this pharmacogenetic algorithm in the clinical
      practice routine could reduce side effects and improve patient safety. TRIAL
      REGISTRATION: Eudra CT. Identifier: 2009-016643-18.
FAU - Carcas, Antonio J
AU  - Carcas AJ
AD  - Clinical Pharmacology Department, La Paz University Hospital, Pharmacology
      Department, School of Medicine, Universidad Autonoma de Madrid, IdiPAZ, Paseo de 
      la Castellana, 261, 28046, Madrid, Spain. antonio.carcas@uam.es
FAU - Borobia, Alberto M
AU  - Borobia AM
FAU - Velasco, Marta
AU  - Velasco M
FAU - Abad-Santos, Francisco
AU  - Abad-Santos F
FAU - Diaz, Manuel Quintana
AU  - Diaz MQ
FAU - Fernandez-Capitan, Carmen
AU  - Fernandez-Capitan C
FAU - Ruiz-Gimenez, Nuria
AU  - Ruiz-Gimenez N
FAU - Madridano, Olga
AU  - Madridano O
FAU - Sillero, Pilar Llamas
AU  - Sillero PL
CN  - PGX-ACE Spanish Investigators Group
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20121213
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
RN  - 0 (Anticoagulants)
RN  - I6WP63U32H (Acenocoumarol)
SB  - IM
MH  - Acenocoumarol/*administration & dosage
MH  - Administration, Oral
MH  - Algorithms
MH  - Anticoagulants/*administration & dosage
MH  - Blood Coagulation/*drug effects/genetics
MH  - Clinical Protocols
MH  - *Drug Dosage Calculations
MH  - Drug Monitoring/methods
MH  - Hemorrhage/chemically induced/genetics/*prevention & control
MH  - Humans
MH  - International Normalized Ratio
MH  - *Pharmacogenetics
MH  - *Research Design
MH  - Single-Blind Method
MH  - Spain
MH  - Time Factors
MH  - Treatment Outcome
MH  - Venous Thromboembolism/blood/*drug therapy/genetics
PMC - PMC3543328
IR  - Sansuan C
FIR - Sansuan, Carcas
IR  - J A
FIR - J, Antonio
IR  - Borobia AM
FIR - Borobia, Alberto M
IR  - Iniesta JF
FIR - Iniesta, Jesus Frias
IR  - Garcia ER
FIR - Garcia, Elena Ramirez
IR  - Velasco M
FIR - Velasco, Marta
IR  - Tong HY
FIR - Tong, Hoi Y
IR  - Diaz MQ
FIR - Diaz, Manuel Quintana
IR  - Virto AM
FIR - Virto, Ana Martinez
IR  - Cadenas SF
FIR - Cadenas, Sara Fabra
IR  - Fernandez-Capitan C
FIR - Fernandez-Capitan, Carmen
IR  - Vinolis MG
FIR - Vinolis, Manuel Gonzalez
IR  - Lorenzo A
FIR - Lorenzo, Alicia
IR  - Davila MA
FIR - Davila, Maria Angeles Rodriguez
IR  - Abad-Santos F
FIR - Abad-Santos, Francisco
IR  - Ochoa D
FIR - Ochoa, Dolores
IR  - Marrodan I
FIR - Marrodan, Igone
IR  - Moreno I
FIR - Moreno, Isabel
IR  - Roman M
FIR - Roman, Manuel
IR  - Verge C
FIR - Verge, Carmen
IR  - Fernandez CS
FIR - Fernandez, Carmen Suarez
IR  - Ruiz-Gimenez N
FIR - Ruiz-Gimenez, Nuria
IR  - Cerezo JG
FIR - Cerezo, Jorge Gomez
IR  - Madridano O
FIR - Madridano, Olga
IR  - del Pozo MM
FIR - del Pozo, Mar Martin
IR  - Sillero PL
FIR - Sillero, Pilar Llamas
IR  - Echevarria AB
FIR - Echevarria, Agustin Blanco
IR  - Pardo EA
FIR - Pardo, Eduardo Arroyo
IR  - Parra AM
FIR - Parra, Ana Maria Lopez
IR  - Baeza C
FIR - Baeza, Carlos
EDAT- 2012/12/15 06:00
MHDA- 2013/07/13 06:00
CRDT- 2012/12/15 06:00
PHST- 2012/06/21 00:00 [received]
PHST- 2012/11/08 00:00 [accepted]
PHST- 2012/12/15 06:00 [entrez]
PHST- 2012/12/15 06:00 [pubmed]
PHST- 2013/07/13 06:00 [medline]
AID - 1745-6215-13-239 [pii]
AID - 10.1186/1745-6215-13-239 [doi]
PST - epublish
SO  - Trials. 2012 Dec 13;13:239. doi: 10.1186/1745-6215-13-239.


PMID- 23237628
OWN - NLM
STAT- MEDLINE
DCOM- 20130613
LR  - 20220318
IS  - 1748-2631 (Electronic)
IS  - 1748-2623 (Linking)
VI  - 7
DP  - 2012 Dec 12
TI  - Happiness in the neonatal intensive care unit: merits of ethnographic fieldwork.
PG  - 1-9
LID - 10.3402/qhw.v7i0.19699 [doi]
AB  - Research has focused on the destructive effects of distress on professionals who 
      work in ethically complex wards such as neonatal intensive units (NICUs). This
      article examines the accounts of health professionals, including nurses,
      pediatricians and assistant nurses, of their work at a NICU in Iceland. The aim
      is to understand how health professionals, who work under stressful conditions in
      an ethically sensitive ward, can counteract the negative sides of work too such a
      degree that they experience happiness. The collection of data was based on the
      ethnographic fieldwork, and the methods used were participant observation and
      semi-structured interviews. The professionals evaluated their wellbeing in line
      with conventional definitions of happiness. Working with children and
      opportunities to help others, engage in social relations and experience
      professional pride contributed to their happiness at work. Nonetheless, they did 
      not dismiss the difficult experiences, and when confronted with these the
      professionals negotiated their meanings and the goals and priorities of work. In 
      contrast to the findings of much quantitative and survey-based research, the
      professionals attributed constructive meanings to stress and argued that the
      positive experiences at work buffered the negative ones. Research on happiness
      would benefit from multifaceted methodological and theoretical perspectives.
      Thanks to its openness to the unforeseen, controversial, contradictory, and
      ambiguous aspects of human life, ethnography can contribute to happiness research
      and research on job satisfaction.
FAU - Einarsdottir, Jonina
AU  - Einarsdottir J
AD  - Department of Anthropology, University of Iceland, Reykjavik, Iceland; je@hi.is
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121212
PL  - United States
TA  - Int J Qual Stud Health Well-being
JT  - International journal of qualitative studies on health and well-being
JID - 101256506
SB  - IM
MH  - Adaptation, Psychological
MH  - Anthropology, Cultural
MH  - Attitude of Health Personnel
MH  - Female
MH  - *Happiness
MH  - Health Personnel/*psychology
MH  - Humans
MH  - Iceland
MH  - *Intensive Care Units, Neonatal/ethics
MH  - Interviews as Topic
MH  - *Job Satisfaction
MH  - Male
MH  - Stress, Psychological
MH  - Workforce
PMC - PMC3521782
EDAT- 2012/12/15 06:00
MHDA- 2013/06/14 06:00
CRDT- 2012/12/15 06:00
PHST- 2012/11/05 00:00 [accepted]
PHST- 2012/12/15 06:00 [entrez]
PHST- 2012/12/15 06:00 [pubmed]
PHST- 2013/06/14 06:00 [medline]
AID - 19699 [pii]
AID - 10.3402/qhw.v7i0.19699 [doi]
PST - epublish
SO  - Int J Qual Stud Health Well-being. 2012 Dec 12;7:1-9. doi:
      10.3402/qhw.v7i0.19699.


PMID- 23237589
OWN - NLM
STAT- MEDLINE
DCOM- 20130510
LR  - 20211021
IS  - 1758-2652 (Electronic)
IS  - 1758-2652 (Linking)
VI  - 15
IP  - 2
DP  - 2012 Dec 5
TI  - The ethics of research in compulsory drug detention centres in Asia.
PG  - 18491
LID - 10.7448/IAS.15.2.18491 [doi]
FAU - Pearshouse, Richard
AU  - Pearshouse R
AD  - Human Rights Watch, New York, NY 10118, USA.
FAU - Amon, Joseph J
AU  - Amon JJ
LA  - eng
PT  - Journal Article
DEP - 20121205
PL  - Switzerland
TA  - J Int AIDS Soc
JT  - Journal of the International AIDS Society
JID - 101478566
SB  - IM
MH  - Adult
MH  - Asia, Southeastern/epidemiology
MH  - Child
MH  - China/epidemiology
MH  - *Coercion
MH  - Delivery of Health Care
MH  - *Ethics, Research
MH  - Homeless Persons
MH  - Humans
MH  - Mental Disorders
MH  - Research Design
MH  - Substance Abuse Treatment Centers/*ethics/*organization & administration
MH  - Torture
PMC - PMC3516672
EDAT- 2012/12/15 06:00
MHDA- 2013/05/11 06:00
CRDT- 2012/12/15 06:00
PHST- 2012/11/12 00:00 [received]
PHST- 2012/11/12 00:00 [accepted]
PHST- 2012/12/15 06:00 [entrez]
PHST- 2012/12/15 06:00 [pubmed]
PHST- 2013/05/11 06:00 [medline]
AID - 18491 [pii]
AID - 10.7448/IAS.15.2.18491 [doi]
PST - epublish
SO  - J Int AIDS Soc. 2012 Dec 5;15(2):18491. doi: 10.7448/IAS.15.2.18491.


PMID- 23237168
OWN - NLM
STAT- MEDLINE
DCOM- 20130328
LR  - 20211021
IS  - 1541-0048 (Electronic)
IS  - 0090-0036 (Linking)
VI  - 103
IP  - 2
DP  - 2013 Feb
TI  - The best possible intentions testing prophylactic approaches on humans in
      developing countries.
PG  - 226-37
LID - 10.2105/AJPH.2012.300901 [doi]
AB  - Debates on human experiments in developing countries focus on ethical principles 
      such as informed consent, accountability, involvement of the concerned
      communities, and the improvement of local health services. Public health
      specialists who conducted human experiments in Rio de Janeiro (1902-1905) and in 
      Guatemala (1947-1948) believed, however, that they were acting in the best
      interests of local populations, were aware of the importance of informed consent,
      were closely collaborating with local health professionals, and were contributing
      to the development of local health structures. Nevertheless, their investigations
      went dramatically wrong. An initial desire to conduct ethically and
      scientifically sound studies was undermined by pressure to obtain results and to 
      save the researchers' initial investment, the possibility of freely using
      hospitalized patients as experimental participants, uncritical help from local
      professional elites, and structural pitfalls of experimenting with severely
      deprived people. These elements can still be found in trials of preventive
      methods in the Global South.
FAU - Lowy, Ilana
AU  - Lowy I
AD  - Centre de recherche, medecine, sciences, sante, sante mentale, societe (INSERM,
      CNRS, EHESS, Paris V), Paris, France. lowy@vjf.cnrs.fr
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121213
PL  - United States
TA  - Am J Public Health
JT  - American journal of public health
JID - 1254074
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Brazil
MH  - *Developing Countries
MH  - France
MH  - Guatemala
MH  - History, 20th Century
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - *Informed Consent
MH  - Sexually Transmitted Diseases/history/*prevention & control
MH  - United States
MH  - United States Public Health Service
MH  - Yellow Fever/history/*prevention & control
PMC - PMC3558769
EDAT- 2012/12/15 06:00
MHDA- 2013/03/30 06:00
CRDT- 2012/12/15 06:00
PHST- 2012/12/15 06:00 [entrez]
PHST- 2012/12/15 06:00 [pubmed]
PHST- 2013/03/30 06:00 [medline]
AID - 10.2105/AJPH.2012.300901 [doi]
PST - ppublish
SO  - Am J Public Health. 2013 Feb;103(2):226-37. doi: 10.2105/AJPH.2012.300901. Epub
      2012 Dec 13.


PMID- 23237119
OWN - NLM
STAT- MEDLINE
DCOM- 20130221
LR  - 20181023
IS  - 0256-9574 (Print)
VI  - 103
IP  - 1
DP  - 2012 Nov 8
TI  - Professionalism in the intimate examination: how healthcare practitioners feel
      about having chaperones present during an intimate consultation and examination.
PG  - 25-7
LID - 10.7196/samj.6224 [doi]
AB  - BACKGROUND: Despite the clear prohibition against sexual relations with one's
      patients, complaints of a sexual nature against practitioners registered with the
      Health Professions Council of South Africa (HPCSA) have been increasing. The
      HPCSA does not provide ethical guidelines regarding the use of a chaperone during
      intimate examinations. AIMS: (i) To ascertain how a group of medical
      practitioners felt about the presence of chaperones during the consultation and
      intimate examination of patients; (ii) to determine whether they currently engage
      the services of chaperones; (iii) to assess how they felt about consensual sexual
      relationships between medical practitioners and their patients. Methods. A
      self-administered, questionnaire-based survey was distributed to gynaecologists
      and medical practitioners. RESULTS: There was a 43% response rate with 72% of
      practitioners in favour of using a chaperone during an intimate examination,
      although only 27% always do so. Most practitioners felt that consensual sexual
      relationships with patients are unacceptable; 83% felt that ethical guidelines on
      this topic were needed. CONCLUSION: The HPCSA should develop guidelines on the
      use of chaperones to assist practitioners. With medical litigation increasing,
      using chaperones will benefit patients and practitioners.
FAU - Guidozzi, Y
AU  - Guidozzi Y
AD  - Steve Biko Centre for Bioethics, University of the Witwatersrand, Johannesburg,
      South Africa. Yolande.Guidozzi@wits.ac.za
FAU - Gardner, J
AU  - Gardner J
FAU - Dhai, A
AU  - Dhai A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20121108
PL  - South Africa
TA  - S Afr Med J
JT  - South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
JID - 0404520
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Female
MH  - Gynecology/*ethics
MH  - Humans
MH  - Male
MH  - Medical Chaperones/*legislation & jurisprudence
MH  - Middle Aged
MH  - Patient Satisfaction
MH  - Physical Examination/*ethics
MH  - *Physician-Patient Relations
MH  - Pilot Projects
MH  - Referral and Consultation/*organization & administration
MH  - South Africa
MH  - Surveys and Questionnaires
EDAT- 2012/12/15 06:00
MHDA- 2013/02/22 06:00
CRDT- 2012/12/15 06:00
PHST- 2012/08/14 00:00 [received]
PHST- 2012/09/26 00:00 [accepted]
PHST- 2012/12/15 06:00 [entrez]
PHST- 2012/12/15 06:00 [pubmed]
PHST- 2013/02/22 06:00 [medline]
AID - 10.7196/samj.6224 [doi]
PST - epublish
SO  - S Afr Med J. 2012 Nov 8;103(1):25-7. doi: 10.7196/samj.6224.


PMID- 23236975
OWN - NLM
STAT- MEDLINE
DCOM- 20130521
LR  - 20220330
IS  - 1876-7591 (Electronic)
IS  - 1876-7591 (Linking)
VI  - 5
IP  - 12
DP  - 2012 Dec
TI  - The napkin-ring sign indicates advanced atherosclerotic lesions in coronary CT
      angiography.
PG  - 1243-52
LID - 10.1016/j.jcmg.2012.03.019 [doi]
LID - S1936-878X(12)00590-6 [pii]
AB  - OBJECTIVES: This study sought to determine the accuracy of plaque pattern
      assessment by coronary computed tomography angiography (CCTA) to differentiate
      between early and advanced atherosclerotic lesions as defined by histology.
      BACKGROUND: A ringlike attenuation pattern of coronary atherosclerotic plaques
      termed as napkin-ring sign (NRS) was described in CCTA of patients who had acute 
      coronary syndrome. METHODS: All procedures were performed in accordance with
      local and federal regulations and the Declaration of Helsinki. Approval of the
      local ethics committees was obtained. We investigated 21 coronary arteries of 7
      donor hearts. Overall, 611 histological sections were obtained and coregistered
      with CCTA images. The CCTA cross sections were read in random order for
      conventional plaque categories (noncalcified [NCP], mixed [MP], calcified [CP])
      and plaque patterns (homogenous, heterogeneous with no napkin-ring sign
      [non-NRS], and heterogeneous with NRS). RESULTS: No plaque was detected in 134
      (21.9%), NCP in 254 (41.6%), MP in 191 (31.3%), and CP in 32 (5.2%) CCTA cross
      sections. The NCP and MP were further classified into homogenous plaques (n =
      207, 46.5%), non-NRS plaques (n = 200, 44.9%), and NRS plaques (n = 38, 8.6%).
      The specificities of NCP and MP to identify advanced lesions were moderate
      (57.9%, 95% confidence interval [CI]: 50.1% to 65.6%, and 72.1%, 95% CI: 64.7% to
      79.4%, respectively), which were similar to the homogenous and heterogeneous
      plaques (62.6%, 95% CI: 54.8% to 70.3%, and 67.3%, 95% CI: 58.6% to 76.1%,
      respectively). In contrast, the specificity of the NRS to identify advanced
      lesions was excellent (98.9%, 95% CI: 97.6% to 100%). The diagnostic performance 
      of the pattern-based scheme to identify advanced lesions was significantly better
      than that of the conventional plaque scheme (area under the curve: 0.761 vs.
      0.678, respectively; p = 0.001). CONCLUSIONS: The assessment of the plaque
      pattern improves diagnostic accuracy of CCTA to identify advanced atherosclerotic
      lesions. The CCTA finding of NRS has a high specificity and high positive
      predictive value for the presence of advanced lesions.
CI  - Copyright (c) 2012 American College of Cardiology Foundation. Published by
      Elsevier Inc. All rights reserved.
FAU - Maurovich-Horvat, Pal
AU  - Maurovich-Horvat P
AD  - Cardiac MR PET CT Program, Department of Radiology, Massachusetts General
      Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.
FAU - Schlett, Christopher L
AU  - Schlett CL
FAU - Alkadhi, Hatem
AU  - Alkadhi H
FAU - Nakano, Masataka
AU  - Nakano M
FAU - Otsuka, Fumiyuki
AU  - Otsuka F
FAU - Stolzmann, Paul
AU  - Stolzmann P
FAU - Scheffel, Hans
AU  - Scheffel H
FAU - Ferencik, Maros
AU  - Ferencik M
FAU - Kriegel, Matthias F
AU  - Kriegel MF
FAU - Seifarth, Harald
AU  - Seifarth H
FAU - Virmani, Renu
AU  - Virmani R
FAU - Hoffmann, Udo
AU  - Hoffmann U
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - JACC Cardiovasc Imaging
JT  - JACC. Cardiovascular imaging
JID - 101467978
SB  - IM
CIN - Future Cardiol. 2013 Mar;9(2):161-2. PMID: 23589907
MH  - Adult
MH  - Coronary Angiography/*methods
MH  - Coronary Artery Disease/*diagnostic imaging/pathology
MH  - Coronary Vessels/*pathology
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Plaque, Atherosclerotic/*diagnostic imaging/pathology
MH  - ROC Curve
MH  - Reproducibility of Results
MH  - Severity of Illness Index
MH  - *Tomography, X-Ray Computed
EDAT- 2012/12/15 06:00
MHDA- 2013/05/23 06:00
CRDT- 2012/12/15 06:00
PHST- 2011/09/12 00:00 [received]
PHST- 2012/02/08 00:00 [revised]
PHST- 2012/03/02 00:00 [accepted]
PHST- 2012/12/15 06:00 [entrez]
PHST- 2012/12/15 06:00 [pubmed]
PHST- 2013/05/23 06:00 [medline]
AID - S1936-878X(12)00590-6 [pii]
AID - 10.1016/j.jcmg.2012.03.019 [doi]
PST - ppublish
SO  - JACC Cardiovasc Imaging. 2012 Dec;5(12):1243-52. doi: 10.1016/j.jcmg.2012.03.019.


PMID- 23236642
STAT- Publisher
DA  - 20121214
PB  - Agency for Healthcare Research and Quality (US)
CTI - AHRQ Methods for Effective Health Care
DP  - 2012 Oct
BTI - Assessing the Impact of Economic Evidence on Policymakers in Health Care-A
      Systematic Review
AB  - BACKGROUND: Many health care experts are demanding greater use of economic
      evidence in the assessment of new and existing health technologies. OBJECTIVES:
      To assess whether and how economic evidence has an impact on health care
      decisionmaking in the United States and in other countries and to identify
      antecedents or obstacles for use in health policy. DATA SOURCES: Searches of
      MEDLINE, EconLit, Cumulative Index to Nursing and Allied Health Literature
      (CINAHL), Embase((R)), and ISI Web of Science(SM) from 1991 until January 2012.
      REVIEW METHODS: The review included original studies that applied a quantitative 
      or qualitative method for evaluating use of economic evidence in any country. We 
      excluded articles that were opinion- or experienced-based without newly generated
      data. Paired reviewers independently determined whether articles met eligibility 
      criteria and then extracted data from eligible studies. Reviewers also assessed
      the quality of each study and graded the strength of the body of evidence using
      an adaptation of the grading of recommendations assessment development and
      evaluation (GRADE) recommendations, indicating study limitations, quality,
      strength of findings, and the type of data available. RESULTS: Of 19,127 titles
      initially screened, 43 studies were included, with all but five published since
      2000. The most frequently studied countries were the United Kingdom (15), and
      Australia, Canada, and the United States (5 each). Most studies (27 studies)
      considered national-level policy and examined the key health actors involved.
      Important decisionmaking topics were reimbursement and health package decisions, 
      and priority setting in program development. Thirty studies found evidence that
      use of economic evidence had a "substantial" impact on health care policymaking, 
      27 of which emphasized at least one other criterion, such as equity
      considerations, usually ill-defined (14 studies), clinical effectiveness, budget 
      impact, ethical reasons, and advocacy arguments. The 30 studies confirmed the
      acceptance of economic evidence as having an impact on either general policy or
      specific decisions, such as reimbursement decisions. In 11 of the studies, the
      use of economic evidence had only a "limited" impact on health policy decisions. 
      In two studies, economic evidence had no impact on health policymaking. A few
      factors played a key role in the use of economic evidence: (1) quality and
      transparency of the studies that provided the economic evidence was a promoting
      factor (7 studies) in the case of a good study and a strong obstacle in the case 
      of a poorly presented study (18 studies); (2) transparency and quality of the
      decisionmaking process was important in the acceptance or rejection of the
      decision (10 studies for acceptance, 13 studies for rejection); and (3) clarity
      of the economic information and the way it was communicated were promoting
      factors (7 studies), while lack of clarity was an obstacle in accepting evidence 
      (17 studies). Of the 37 observational studies of policy impact, 11 (30%) received
      a favorable rating on more than three of the 8 items on the study quality
      checklist. Five of the studies had a comparison group and provided intermediate
      quality evidence that economic evidence is useful in general health policymaking.
      CONCLUSIONS: The body of evidence on the use of economic evidence in policy is
      small and patchy. It shows that the utility of economic evidence, alone or in
      combination with systematic reviews, is influenced by technical issues, such as
      transparency and clarity, as well as by the transparency of the decisionmaking
      process.
FAU - Niessen, Louis W
AU  - Niessen LW
FAU - Bridges, John
AU  - Bridges J
FAU - Lau, Brandyn D
AU  - Lau BD
FAU - Wilson, Renee F
AU  - Wilson RF
FAU - Sharma, Ritu
AU  - Sharma R
FAU - Walker, Damian G
AU  - Walker DG
FAU - Frick, Kevin D
AU  - Frick KD
FAU - Bass, Eric B
AU  - Bass EB
LA  - eng
PT  - Review
PT  - Book
PL  - Rockville (MD)
EDAT- 2012/12/14 06:00
MHDA- 2012/12/14 06:00
CDAT- 2012/12/14 06:00
AID - NBK114636 [bookaccession]


PMID- 23236087
OWN - NLM
STAT- MEDLINE
DCOM- 20130527
LR  - 20220321
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 4
DP  - 2013 Apr
TI  - Relative efficacy of cash versus vouchers in engaging opioid substitution
      treatment clients in survey-based research.
PG  - 253-6
LID - 10.1136/medethics-2012-100884 [doi]
AB  - Concerns that cash payments to people who inject drugs (PWID) to reimburse
      research participation will facilitate illicit drug purchases have led some
      ethical authorities to mandate department store/supermarket vouchers as research 
      reimbursement. To examine the relative efficacy of the two forms of reimbursement
      in engaging PWID in research, clients of two public opioid substitution therapy
      clinics were invited to participate in a 20-30 min, anonymous and confidential
      interview about alcohol consumption on two separate occasions, 4 months apart.
      Under the crossover design, at Time 1, clients of Clinic 1 were offered $A20 cash
      as reimbursement, while clients of Clinic 2 were offered an $A20 voucher; at Time
      2, the form of reimbursement was reversed. Using clinic records to determine the 
      denominator (number of clients dosed), we found that compared with clients
      offered a voucher, a significantly higher proportion of clients who were offered 
      cash participated in the survey (58% (139/241) vs 74% (186/252); chi(2)=14.27;
      p=0.0002). At first participation, respondents most commonly reported planning to
      purchase food/drinks/groceries (68%), cigarettes (21%) and transport/fuel (11%)
      with their payments, with those reimbursed in cash more likely to report planning
      to fund transport/fuel (19% vs 1%; p<.01) and less likely to report planning to
      purchase food/drinks/groceries (62% vs 76%; p=0.02). Just three out of 155 cash
      participants reported planning to purchase illicit drugs with their payment.
      Results demonstrate that modest cash payments enhanced recruitment of this group,
      an important consideration given the challenges of delineating the parameters of 
      a population defined by illegal activity, seemingly without promoting excessive
      additional drug use.
FAU - Topp, Libby
AU  - Topp L
AD  - Viral Hepatitis Epidemiology and Prevention Program, The Kirby Institute,
      University of New South Wales, Sydney, New South Wales, Australia.
FAU - Islam, M Mofizul
AU  - Islam MM
FAU - Day, Carolyn Ann
AU  - Day CA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121212
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Adult
MH  - Cross-Over Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - New South Wales
MH  - *Opiate Substitution Treatment
MH  - Research Subjects/*economics
MH  - *Salaries and Fringe Benefits
MH  - Substance-Related Disorders/*therapy
MH  - Surveys and Questionnaires
EDAT- 2012/12/14 06:00
MHDA- 2013/05/29 06:00
CRDT- 2012/12/14 06:00
PHST- 2012/12/14 06:00 [entrez]
PHST- 2012/12/14 06:00 [pubmed]
PHST- 2013/05/29 06:00 [medline]
AID - medethics-2012-100884 [pii]
AID - 10.1136/medethics-2012-100884 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Apr;39(4):253-6. doi: 10.1136/medethics-2012-100884. Epub 2012
      Dec 12.


PMID- 23236086
OWN - NLM
STAT- MEDLINE
DCOM- 20141112
LR  - 20141120
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 10
DP  - 2013 Oct
TI  - New trends of short-term humanitarian medical volunteerism: professional and
      ethical considerations.
PG  - 625-31
LID - 10.1136/medethics-2011-100488 [doi]
AB  - Short-term humanitarian medical volunteerism has grown significantly among both
      clinicians and trainees over the past several years. Increasingly, both
      volunteers and their respective institutions have faced important challenges in
      regard to medical ethics and professional codes that should not be overlooked. We
      explore these potential concerns and their risk factors in three categories:
      ethical responsibilities in patient care, professional responsibility to
      communities and populations, and institutional responsibilities towards trainees.
      We discuss factors increasing the risk of harm to patients and communities,
      including inadequate preparation, the use of advanced technology and the
      translation of Western medicine, issues with clinical epidemiology and test
      utility, difficulties with the principles of justice and clinical justice, the
      lack of population-based medicine, sociopolitical effects of foreign aid,
      volunteer stress management, and need for sufficient trainee supervision. We
      review existing resources and offer suggestions for future skill-based training, 
      organisational responsibilities, and ethical preparation.
FAU - Asgary, Ramin
AU  - Asgary R
AD  - Department of Medicine, New York University School of Medicine, , New York, New
      York, USA.
FAU - Junck, Emily
AU  - Junck E
LA  - eng
PT  - Journal Article
DEP - 20121212
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Altruism
MH  - *Ethics, Medical
MH  - Global Health
MH  - Humans
MH  - Organization and Administration/standards
MH  - Patient Care/ethics/standards
MH  - Patient Harm
MH  - Risk Factors
MH  - Social Justice
MH  - *Volunteers
MH  - Workload/psychology
OTO - NOTNLM
OT  - Applied and Professional Ethics
OT  - Clinical Ethics
OT  - Education for Health Care Professionals
OT  - Public Health Ethics
EDAT- 2012/12/14 06:00
MHDA- 2014/11/13 06:00
CRDT- 2012/12/14 06:00
PHST- 2012/12/14 06:00 [entrez]
PHST- 2012/12/14 06:00 [pubmed]
PHST- 2014/11/13 06:00 [medline]
AID - medethics-2011-100488 [pii]
AID - 10.1136/medethics-2011-100488 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Oct;39(10):625-31. doi: 10.1136/medethics-2011-100488. Epub
      2012 Dec 12.


PMID- 23236085
OWN - NLM
STAT- MEDLINE
DCOM- 20140113
LR  - 20181202
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 8
DP  - 2013 Aug
TI  - How not to argue against mandatory ethics review.
PG  - 521-4
LID - 10.1136/medethics-2012-101074 [doi]
AB  - There is considerable controversy about the mandatory ethics review of research. 
      This paper engages with the arguments offered by Murray Dyck and Gary Allen
      against mandatory review, namely, that this regulation fails to reach the
      standards that research ethics committees apply to research since it is harmful
      to the ethics of researchers, has little positive evidence base, leads to
      significant harms (through delaying valuable research) and distorts the nature of
      research. As these are commonplace arguments offered by researchers against
      regulation it is useful to assess their strength and the conclusion that they are
      taken to support, namely, that we ought to move back to a system of trust in
      researchers without compulsory regulation. Unfortunately, these arguments are at 
      best weak and to some degree come into conflict in terms of supporting the
      desired conclusion.
FAU - Hunter, David
AU  - Hunter D
AD  - Department of Philosophy, University of Birmingham, ERI Building, Birmingham B15 
      2TT, UK. d.hunter@bham.ac.uk
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20121212
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
CON - J Med Ethics. 2013 Aug;39(8):517-20. PMID: 22865925
MH  - *Beneficence
MH  - Biomedical Research/*ethics
MH  - Ethics Committees, Research/*economics/*ethics
MH  - *Ethics, Research
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - *Personal Autonomy
MH  - Research Personnel/*ethics
MH  - *Social Justice
OTO - NOTNLM
OT  - Applied and Professional Ethics
OT  - History of Health Ethics/Bioethics
OT  - Regulation
OT  - Research Ethics
OT  - Social Control of Human Experimentation
EDAT- 2012/12/14 06:00
MHDA- 2014/01/15 06:00
CRDT- 2012/12/14 06:00
PHST- 2012/12/14 06:00 [entrez]
PHST- 2012/12/14 06:00 [pubmed]
PHST- 2014/01/15 06:00 [medline]
AID - medethics-2012-101074 [pii]
AID - 10.1136/medethics-2012-101074 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Aug;39(8):521-4. doi: 10.1136/medethics-2012-101074. Epub 2012
      Dec 12.


PMID- 23236084
OWN - NLM
STAT- MEDLINE
DCOM- 20130812
LR  - 20151119
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 6
DP  - 2013 Jun
TI  - Is it a boy or a girl? Who should (not) know children's sex and why?
PG  - 374-7
LID - 10.1136/medethics-2011-100415 [doi]
AB  - In this paper, we present the case of a couple who refused to disclose the sex of
      their child to others, and some of the responses that this case prompted in the
      international media. We outline the ethical issues that this case raises, and we 
      place it into the more general context of parental preferences regarding the
      gender (development) of their children and of the impact on children of parental 
      choices in the matter. Based on current knowledge of gender identity development,
      we identify some of the potential pitfalls of such a course of action and we
      briefly present some alternative strategies that could be implemented in order to
      ensure more freedom of gender formation in children.
FAU - Cutas, Daniela E
AU  - Cutas DE
AD  - Department of Health, Ethics and Society, Maastricht University, PO Box 616, 6200
      Maastricht, The Netherlands. d.cutas@maastrichtuniversity.nl
FAU - Giordano, Simona
AU  - Giordano S
LA  - eng
PT  - Journal Article
DEP - 20121212
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Ethical Analysis
MH  - *Family Characteristics
MH  - Female
MH  - *Gender Identity
MH  - Humans
MH  - Male
MH  - Parent-Child Relations
MH  - Parents
MH  - Pregnancy
MH  - *Social Values
MH  - *Stereotyping
MH  - Sweden
MH  - *Transgender Persons/psychology
OTO - NOTNLM
OT  - Family
OT  - Sexuality/Gender
OT  - Social Aspects
EDAT- 2012/12/14 06:00
MHDA- 2013/08/13 06:00
CRDT- 2012/12/14 06:00
PHST- 2012/12/14 06:00 [entrez]
PHST- 2012/12/14 06:00 [pubmed]
PHST- 2013/08/13 06:00 [medline]
AID - medethics-2011-100415 [pii]
AID - 10.1136/medethics-2011-100415 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Jun;39(6):374-7. doi: 10.1136/medethics-2011-100415. Epub 2012
      Dec 12.


PMID- 23235579
OWN - NLM
STAT- MEDLINE
DCOM- 20130221
LR  - 20200511
IS  - 1469-493X (Electronic)
IS  - 1361-6137 (Linking)
VI  - 12
DP  - 2012 Dec 12
TI  - Enteral tube feeding for cystic fibrosis.
PG  - CD001198
LID - 10.1002/14651858.CD001198.pub3 [doi]
AB  - BACKGROUND: Enteral tube feeding is routinely used in many cystic fibrosis
      centres when oral dietary and supplement intake has failed to achieve an adequate
      nutritional status. The use of this method of feeding is assessed on an
      individual basis taking into consideration the patients age and clinical status. 
      OBJECTIVES: To examine the evidence that in people with cystic fibrosis,
      supplemental enteral tube feeding improves nutritional status, respiratory
      function, and quality of life without significant adverse effects. SEARCH
      METHODS: We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group
      Trials Register which comprises references identified from comprehensive
      electronic database searches and handsearches of relevant journals and abstract
      books of conference proceedings. We also contacted the companies that market
      enteral feeds and reviewed their databases.Date of the most recent search of the 
      Group's Cystic Fibrosis Trials Register: 03 September 2012.Date of the most
      recent hand search of PubMed and conference abstract books: 15 June 2012.
      SELECTION CRITERIA: All randomised controlled trials comparing supplemental
      enteral tube feeding for one month or longer with no specific intervention in
      people with cystic fibrosis. DATA COLLECTION AND ANALYSIS: Thirty-one trials were
      identified by the searches; however, none were eligible for inclusion in this
      review. MAIN RESULTS: There are no trials included in this review. AUTHORS'
      CONCLUSIONS: Supplemental enteral tube feeding is widely used throughout the
      world to improve nutritional status in people with cystic fibrosis. The methods
      mostly used, nasogastric or gastrostomy feeding, are expensive and may have a
      negative effect on self-esteem and body image. Reported use of enteral tube
      feeding suggests that it results in nutritional and respiratory improvement; but,
      efficacy has not been fully assessed by randomised controlled trials. It is
      acknowledged, however, that performing a randomised controlled trial would be
      difficult due to the ethics of withholding an intervention in a group of patients
      whose nutritional status necessitates it.
FAU - Conway, Steven
AU  - Conway S
AD  - Regional Adult Cystic Fibrosis Unit, St James'Hospital, Leeds,UK.
      Steven.Conway@leedsth.nhs.uk.
FAU - Morton, Alison
AU  - Morton A
FAU - Wolfe, Susan
AU  - Wolfe S
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20121212
PL  - England
TA  - Cochrane Database Syst Rev
JT  - The Cochrane database of systematic reviews
JID - 100909747
SB  - IM
UIN - Cochrane Database Syst Rev. 2015;4:CD001198. PMID: 25854213
UOF - Cochrane Database Syst Rev. 2008;(2):CD001198. PMID: 18425869
MH  - Cystic Fibrosis/*therapy
MH  - *Dietary Supplements
MH  - *Enteral Nutrition
MH  - Humans
MH  - *Nutritional Status
MH  - Quality of Life
EDAT- 2012/12/14 06:00
MHDA- 2013/02/22 06:00
CRDT- 2012/12/14 06:00
PHST- 2012/12/14 06:00 [entrez]
PHST- 2012/12/14 06:00 [pubmed]
PHST- 2013/02/22 06:00 [medline]
AID - 10.1002/14651858.CD001198.pub3 [doi]
PST - epublish
SO  - Cochrane Database Syst Rev. 2012 Dec 12;12:CD001198. doi:
      10.1002/14651858.CD001198.pub3.


PMID- 23234571
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130524
LR  - 20211021
IS  - 1756-0381 (Electronic)
IS  - 1756-0381 (Linking)
VI  - 5
IP  - 1
DP  - 2012 Dec 12
TI  - Multivariate methods and software for association mapping in dose-response
      genome-wide association studies.
PG  - 21
LID - 10.1186/1756-0381-5-21 [doi]
AB  - BACKGROUND: The large sample sizes, freedom of ethical restrictions and ease of
      repeated measurements make cytotoxicity assays of immortalized lymphoblastoid
      cell lines a powerful new in vitro method in pharmacogenomics research. However, 
      previous studies may have over-simplified the complex differences in
      dose-response profiles between genotypes, resulting in a loss of power. METHODS: 
      The current study investigates four previously studied methods, plus one new
      method based on a multivariate analysis of variance (MANOVA) design. A simulation
      study was performed using differences in cancer drug response between genotypes
      for biologically meaningful loci. These loci also showed significance in separate
      genome-wide association studies. This manuscript builds upon a previous study,
      where differences in dose-response curves between genotypes were constructed
      using the hill slope equation. CONCLUSION: Overall, MANOVA was found to be the
      most powerful method for detecting real signals, and was also the most robust
      method for detection using alternatives generated with the previous simulation
      study. This method is also attractive because test statistics follow their
      expected distributions under the null hypothesis for both simulated and real
      data. The success of this method inspired the creation of the software program
      MAGWAS. MAGWAS is a computationally efficient, user-friendly, open source
      software tool that works on most platforms and performs GWASs for individuals
      having multivariate responses using standard file formats.
FAU - Brown, Chad C
AU  - Brown CC
AD  - Department of Statistics, North Carolina State University, Raleigh, NC, USA.
      motsinger@stat.ncsu.edu.
FAU - Havener, Tammy M
AU  - Havener TM
FAU - Medina, Marisa Wong
AU  - Medina MW
FAU - Krauss, Ronald M
AU  - Krauss RM
FAU - McLeod, Howard L
AU  - McLeod HL
FAU - Motsinger-Reif, Alison A
AU  - Motsinger-Reif AA
LA  - eng
GR  - R01 CA161608/CA/NCI NIH HHS/United States
GR  - R01 HL104133/HL/NHLBI NIH HHS/United States
PT  - Journal Article
DEP - 20121212
PL  - England
TA  - BioData Min
JT  - BioData mining
JID - 101319161
PMC - PMC3661384
EDAT- 2012/12/14 06:00
MHDA- 2012/12/14 06:01
CRDT- 2012/12/14 06:00
PHST- 2012/04/03 00:00 [received]
PHST- 2012/12/04 00:00 [accepted]
PHST- 2012/12/14 06:00 [entrez]
PHST- 2012/12/14 06:00 [pubmed]
PHST- 2012/12/14 06:01 [medline]
AID - 1756-0381-5-21 [pii]
AID - 10.1186/1756-0381-5-21 [doi]
PST - epublish
SO  - BioData Min. 2012 Dec 12;5(1):21. doi: 10.1186/1756-0381-5-21.


PMID- 23234422
OWN - NLM
STAT- MEDLINE
DCOM- 20130506
LR  - 20220331
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 13
DP  - 2012 Dec 12
TI  - Review of national research ethics regulations and guidelines in Middle Eastern
      Arab countries.
PG  - 34
LID - 10.1186/1472-6939-13-34 [doi]
AB  - BACKGROUND: Research ethics guidelines are essential for conducting medical
      research. Recently, numerous attempts have been made to establish national
      clinical research documents in the countries of the Middle East. This article
      analyzes these documents. METHODS: Thirteen Arab countries in the Middle East
      were explored for available national codes, regulations, and guidelines
      concerning research ethics, and 10 documents from eight countries were found. We 
      studied these documents, considering the ethical principles stated in the
      Declaration of Helsinki, the Council for International Organizations of Medical
      Sciences (CIOMS) guidelines, and the International Conference of
      Harmonization-Guidelines for Good Clinical Practice (ICH-GCP). Our paper
      comprises a complete list of protections, such as confidentiality, informed
      consent, ethics committees, and others. RESULTS: This study found different
      levels and kinds of research ethics regulations and guidelines in the countries
      examined. Two groups can be distinguished: the countries in the first group have 
      one or more research ethics regulations or guidelines, while the countries in the
      second group have not yet established any. Most of the documents showed various
      degrees of deficiencies in regard to ethical protection. The majority of the
      documents that were examined refer to one or more international documents on
      biomedical research ethics. CONCLUSIONS: Recently, a lot of efforts have been
      made in many countries in the Middle East. However, compared with international
      documents, most of the research ethics documents in use in this region
      demonstrate numerous deficiencies. As it relates to these documents, extensive
      differences could be observed in regard to development, structure, content, and
      reference to international guidelines.
FAU - Alahmad, Ghiath
AU  - Alahmad G
AD  - King Abdullah International Medical Research Center, King Saud bin Abdulaziz
      University for Health Sciences, Box: 22490, Riyadh 11426, Saudi Arabia.
      ghiathalahmad@hotmail.com
FAU - Al-Jumah, Mohammad
AU  - Al-Jumah M
FAU - Dierickx, Kris
AU  - Dierickx K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
DEP - 20121212
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Codes of Ethics
MH  - Confidentiality/ethics/legislation & jurisprudence/standards
MH  - Ethics Committees, Research/ethics/legislation & jurisprudence/standards
MH  - *Ethics, Research
MH  - *Guidelines as Topic/standards
MH  - Health Expenditures
MH  - Helsinki Declaration
MH  - Humans
MH  - Informed Consent/ethics/legislation & jurisprudence/standards
MH  - International Cooperation
MH  - Middle East
PMC - PMC3576357
EDAT- 2012/12/14 06:00
MHDA- 2013/05/07 06:00
CRDT- 2012/12/14 06:00
PHST- 2012/07/30 00:00 [received]
PHST- 2012/11/29 00:00 [accepted]
PHST- 2012/12/14 06:00 [entrez]
PHST- 2012/12/14 06:00 [pubmed]
PHST- 2013/05/07 06:00 [medline]
AID - 1472-6939-13-34 [pii]
AID - 10.1186/1472-6939-13-34 [doi]
PST - epublish
SO  - BMC Med Ethics. 2012 Dec 12;13:34. doi: 10.1186/1472-6939-13-34.


PMID- 23234238
OWN - NLM
STAT- MEDLINE
DCOM- 20130627
LR  - 20131121
IS  - 1936-086X (Electronic)
IS  - 1936-0851 (Linking)
VI  - 7
IP  - 1
DP  - 2013 Jan 22
TI  - Artificial enzyme-powered microfish for water-quality testing.
PG  - 818-24
LID - 10.1021/nn305372n [doi]
AB  - We present a novel micromotor-based strategy for water-quality testing based on
      changes in the propulsion behavior of artificial biocatalytic microswimmers in
      the presence of aquatic pollutants. The new micromotor toxicity testing concept
      mimics live-fish water testing and relies on the toxin-induced inhibition of the 
      enzyme catalase, responsible for the biocatalytic bubble propulsion of tubular
      microengines. The locomotion and survival of the artificial microfish are thus
      impaired by exposure to a broad range of contaminants, that lead to distinct
      time-dependent irreversible losses in the catalase activity, and hence of the
      propulsion behavior. Such use of enzyme-powered biocompatible polymeric
      (PEDOT)/Au-catalase tubular microengine offers highly sensitive direct optical
      visualization of changes in the swimming behavior in the presence of common
      contaminants and hence to a direct real-time assessment of the water quality.
      Quantitative data on the adverse effects of the various toxins upon the swimming 
      behavior of the enzyme-powered artificial swimmer are obtained by estimating
      common ecotoxicological parameters, including the EC(50) (exposure concentration 
      causing 50% attenuation of the microfish locomotion) and the swimmer survival
      time (lifetime expectancy). Such novel use of artificial microfish addresses
      major standardization and reproducibility problems as well as ethical concerns
      associated with live-fish toxicity assays and hence offers an attractive
      alternative to the common use of aquatic organisms for water-quality testing.
FAU - Orozco, Jahir
AU  - Orozco J
AD  - Department of Nanoengineering, University of California, San Diego, La Jolla,
      California 92093, USA.
FAU - Garcia-Gradilla, Victor
AU  - Garcia-Gradilla V
FAU - D'Agostino, Mattia
AU  - D'Agostino M
FAU - Gao, Wei
AU  - Gao W
FAU - Cortes, Allan
AU  - Cortes A
FAU - Wang, Joseph
AU  - Wang J
LA  - eng
GR  - Howard Hughes Medical Institute/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20121218
PL  - United States
TA  - ACS Nano
JT  - ACS nano
JID - 101313589
RN  - 0 (Enzymes)
RN  - 0 (Molecular Motor Proteins)
RN  - 0 (Water Pollutants, Chemical)
RN  - 059QF0KO0R (Water)
SB  - IM
MH  - Animals
MH  - Environmental Monitoring/*methods
MH  - Enzymes/*analysis/*chemistry
MH  - *Fishes
MH  - Materials Testing
MH  - Molecular Motor Proteins/*chemistry
MH  - Water/*analysis
MH  - Water Pollutants, Chemical/*analysis/*chemistry
EDAT- 2012/12/14 06:00
MHDA- 2013/06/29 06:00
CRDT- 2012/12/14 06:00
PHST- 2012/12/14 06:00 [entrez]
PHST- 2012/12/14 06:00 [pubmed]
PHST- 2013/06/29 06:00 [medline]
AID - 10.1021/nn305372n [doi]
PST - ppublish
SO  - ACS Nano. 2013 Jan 22;7(1):818-24. doi: 10.1021/nn305372n. Epub 2012 Dec 18.


PMID- 23234202
OWN - NLM
STAT- MEDLINE
DCOM- 20130402
LR  - 20121213
IS  - 0033-2658 (Print)
IS  - 0033-2658 (Linking)
VI  - 114
IP  - 10
DP  - 2012
TI  - [Will electroconvulsive therapy disappear in the near future?].
PG  - 1208-15
AB  - Electroconvulsive therapy (ECT) has been widely used, with some modification of
      its methods, for the treatment of refractory mental disorders. In Japan,
      brief-pulse ECT was approved in 2002 under conditions that well-trained
      psychiatrists should administer ECT and that modified ECT is mandatory. However, 
      unmodified ECT is still often performed in Japan. We have to improve safety of
      ECT further. Major indications for ECT are depression and catatonia. Mechanisms
      of ECT are still unknown, but the neurogenesis hypothesis is promising.
      Furthermore, several brain stimulation techniques without seizure induction, such
      as transcranial magnetic stimulation, vagus nerve stimulation, deep brain
      stimulation and transcranial direct current stimulation, have been introduced for
      the treatment of refractory mental disorders. Ethical criteria must be determined
      for further research and treatment with these techniques.
FAU - Motohashi, Nobutaka
AU  - Motohashi N
AD  - Department of Neuropsychiatry, Interdisciplinary Graduate School of Medicine and 
      Engineering, University of Yamanashi.
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Seishin Shinkeigaku Zasshi
JT  - Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica
JID - 9801787
SB  - IM
MH  - Deep Brain Stimulation/methods
MH  - Electroconvulsive Therapy/*methods/*trends
MH  - Humans
MH  - Mental Disorders/*therapy
MH  - Transcranial Magnetic Stimulation/methods
MH  - Vagus Nerve Stimulation/methods
EDAT- 2012/12/14 06:00
MHDA- 2013/04/03 06:00
CRDT- 2012/12/14 06:00
PHST- 2012/12/14 06:00 [entrez]
PHST- 2012/12/14 06:00 [pubmed]
PHST- 2013/04/03 06:00 [medline]
PST - ppublish
SO  - Seishin Shinkeigaku Zasshi. 2012;114(10):1208-15.


PMID- 23234096
OWN - NLM
STAT- MEDLINE
DCOM- 20130220
LR  - 20151119
IS  - 0033-2941 (Print)
IS  - 0033-2941 (Linking)
VI  - 111
IP  - 2
DP  - 2012 Oct
TI  - Multidimensional relationships between paternalistic leadership and perceptions
      of organizational ethical climates.
PG  - 509-27
AB  - This study investigated how paternalistic leadership is linked to ethical
      climates based on a multidimensional construct perspective. This experimental
      study utilized the partial least squares (PLS) techniques to analyze the data.
      Participants were 258 civil servants working in various public sectors in Taiwan,
      who were asked to rate their leaders' paternalistic leadership behaviors and
      their perception of the ethical climates in their organizations using the
      Paternalistic Leadership Scale and the Ethical Climate Questionnaire. Using the
      unidimensional constructs of paternalistic leadership and ethical climates, prior
      research showed vidence of a positive relationship; however, in the current
      study, multidimensional relations among these constructs may be positive or
      negative. The findings of this study suggested that leaders may implement
      specific types of paternalistic leadership to enhance the intended ethical
      climate in their organizations.
FAU - Wu, Yu-Chi
AU  - Wu YC
AD  - Institute of Business and Management, National University of Kaohsiung, Taiwan.
      sycwu@nuk.edu.tw
FAU - Tsai, Ping Ju
AU  - Tsai PJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Psychol Rep
JT  - Psychological reports
JID - 0376475
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - *Leadership
MH  - Male
MH  - Middle Aged
MH  - Models, Statistical
MH  - *Organizational Culture
MH  - *Paternalism
MH  - *Social Perception
MH  - Surveys and Questionnaires
MH  - Taiwan
EDAT- 2012/12/14 06:00
MHDA- 2013/02/21 06:00
CRDT- 2012/12/14 06:00
PHST- 2012/12/14 06:00 [entrez]
PHST- 2012/12/14 06:00 [pubmed]
PHST- 2013/02/21 06:00 [medline]
AID - 10.2466/01.17.PR0.111.5.509-527 [doi]
PST - ppublish
SO  - Psychol Rep. 2012 Oct;111(2):509-27. doi: 10.2466/01.17.PR0.111.5.509-527.


PMID- 23233832
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121213
LR  - 20211021
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 6
DP  - 2012
TI  - Elevated Salivary Levels of Oxytocin Persist More than 7 h after Intranasal
      Administration.
PG  - 174
LID - 10.3389/fnins.2012.00174 [doi]
AB  - We addressed the question how long salivary oxytocin levels remain elevated after
      intranasal administration, and whether it makes a difference when 16 or 24 IU of 
      oxytocin administration is used. Oxytocin levels were measured in saliva samples 
      collected from 46 female participants right before intranasal administration (at 
      9:30 a.m.) of 16 IU (n = 18) or 24 IU (n = 10) of oxytocin, or a placebo (n =
      18), and each hour after administration, for 7 h in total. Oxytocin levels did
      not differ among conditions before use of the nasal spray. Salivary oxytocin
      levels in the placebo group showed high stability across the day. After oxytocin 
      administration oxytocin levels markedly increased, they peaked around 1 h after
      administration, and were still significantly elevated 7 h after administration.
      The amount of oxytocin (16 or 24 IU) did not make a difference for oxytocin
      levels. The increase of oxytocin levels for at least 7 h shows how effective
      intranasal administration of oxytocin is. Our findings may raise ethical
      questions about potentially persisting behavioral effects after participants have
      left the lab setting. More research into the long-term neurological and
      behavioral effects of sniffs of oxytocin is urgently needed.
FAU - van Ijzendoorn, Marinus H
AU  - van Ijzendoorn MH
AD  - Centre for Child and Family Studies, Leiden University Leiden, Netherlands ;
      Leiden Institute for Brain and Cognition, Leiden University Leiden, Netherlands.
FAU - Bhandari, Ritu
AU  - Bhandari R
FAU - van der Veen, Rixt
AU  - van der Veen R
FAU - Grewen, Karen M
AU  - Grewen KM
FAU - Bakermans-Kranenburg, Marian J
AU  - Bakermans-Kranenburg MJ
LA  - eng
PT  - Journal Article
DEP - 20121207
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC3516702
OTO - NOTNLM
OT  - 16 IU
OT  - behavioral effects
OT  - daily oxytocin curve
OT  - ethics
OT  - healthy female volunteers
OT  - intranasal administration
OT  - oxytocin
OT  - saliva
EDAT- 2012/12/13 06:00
MHDA- 2012/12/13 06:01
CRDT- 2012/12/13 06:00
PHST- 2012/10/08 00:00 [received]
PHST- 2012/11/16 00:00 [accepted]
PHST- 2012/12/13 06:00 [entrez]
PHST- 2012/12/13 06:00 [pubmed]
PHST- 2012/12/13 06:01 [medline]
AID - 10.3389/fnins.2012.00174 [doi]
PST - epublish
SO  - Front Neurosci. 2012 Dec 7;6:174. doi: 10.3389/fnins.2012.00174. eCollection
      2012.


PMID- 23233701
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121213
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 6
DP  - 2012
TI  - A randomised controlled trial comparing surgical intervention rates between two
      protocols for the management of asymptomatic adnexal tumours in postmenopausal
      women.
LID - 10.1136/bmjopen-2012-002248 [doi]
LID - e002248 [pii]
AB  - INTRODUCTION: Detection of asymptomatic adnexal tumours in postmenopausal women
      has increased due to wider use of diagnostic ultrasound and imaging quality
      improvements. Reliable methods to differentiate between benign and malignant
      tumours are required to avoid delays in treating ovarian cancer and to prevent
      unnecessary interventions for benign lesions. In the UK, the Royal College of
      Obstetricians and Gynaecologists has issued guidance for the management of
      adnexal cysts in postmenopausal women, which is considered standard in routine
      clinical practice. The protocol utilises the Risk of Malignancy Index to assess
      the risk of adnexal lesion being malignant. This protocol has a relatively high
      intervention rate in order to avoid a delay in a cancer diagnosis. The Simple
      Rules Protocol designed by International Ovarian Tumour Analysis Group reports a 
      low false-positive rate in the diagnosis of ovarian cancer without a loss of
      sensitivity and therefore has the potential to reduce unnecessary interventions
      in asymptomatic postmenopausal women with benign cysts. METHODS AND ANALYSIS: 140
      postmenopausal women aged 40-80, with incidentally detected adnexal tumours on
      ultrasound scan will be recruited to this study. They will be randomly allocated,
      to be assessed and managed according to either of the two protocols under
      investigation. In both arms of the study the tumours will be classified into
      three groups: high, intermediate or low risk of malignancy. Women with high risk 
      of malignancy will be referred for management in a tertiary cancer centre, women 
      with low-risk tumours will be managed expectantly, while those with intermediate 
      risk findings have surgery in their local hospital units. Analysis will be on an 
      intention-to-treat basis. ETHICS AND DISSEMINATION: Research ethical approval was
      granted by the North London Research Ethical Committee 2 (10/H0724/48). Trial
      results will be published according to the CONSORT statement. TRIAL REGISTRATION 
      NUMBER: Registration at http://www.controlled-trials.com/ISRCTN89034131/.
      ISRCTN89034131.
FAU - Nunes, Natalie
AU  - Nunes N
AD  - Gynaecological Diagnostic Outpatient Treatment Unit, University College Hospital,
      London, UK.
FAU - Foo, Xulin
AU  - Foo X
FAU - Widschwendter, Martin
AU  - Widschwendter M
FAU - Jurkovic, Davor
AU  - Jurkovic D
LA  - eng
PT  - Journal Article
DEP - 20121211
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3533090
EDAT- 2012/12/13 06:00
MHDA- 2012/12/13 06:01
CRDT- 2012/12/13 06:00
PHST- 2012/12/13 06:00 [entrez]
PHST- 2012/12/13 06:00 [pubmed]
PHST- 2012/12/13 06:01 [medline]
AID - bmjopen-2012-002248 [pii]
AID - 10.1136/bmjopen-2012-002248 [doi]
PST - epublish
SO  - BMJ Open. 2012 Dec 11;2(6). pii: bmjopen-2012-002248. doi:
      10.1136/bmjopen-2012-002248. Print 2012.


PMID- 23233110
OWN - NLM
STAT- MEDLINE
DCOM- 20131209
LR  - 20211021
IS  - 1573-3599 (Electronic)
IS  - 1059-7700 (Linking)
VI  - 22
IP  - 3
DP  - 2013 Jun
TI  - Ethical issues in presymptomatic genetic testing for minors: a dilemma in
      Li-Fraumeni syndrome.
PG  - 315-22
LID - 10.1007/s10897-012-9556-0 [doi]
AB  - In 2001, a French expert panel recommended that presymptomatic tests should not
      be carried out on minors in families affected by Li-Fraumeni syndrome (LFS),
      flying in the face of possible parental demands for such testing. We decided to
      investigate the legitimacy of such a recommendation. We conducted a national
      multicenter survey using self-administered questionnaires mailed to French
      oncogeneticists in 33 regional centers in France. We aimed to (1) determine the
      extent to which these doctors were confronted with parental requests for TP53
      testing, (2) study how they responded to these requests and the arguments used
      and (3) assess the attitude of oncogeneticists concerning the normative framework
      regulating the prescription of tests for minors. Twenty oncogeneticists stated
      that they had managed at least one LFS family. Eleven of these doctors had been
      confronted with parental requests for testing and three had prescribed such tests
      on at least one occasion. The oncogeneticists gave balanced medical,
      psychological and ethical arguments, highlighting the dilemma they face in the
      decision-making process. This dilemma is due to the lack of a consensus
      concerning this recommendation, which aims to protect the minor by limiting
      presymptomatic tests to cases in which a clear medical benefit can be
      demonstrated but which prevents the unique situation of particular families from 
      being taken into account. In conclusion, the recommendation has a normative
      status but first, from a clinical stance, it is difficult to dissociate it from
      the evaluation of individual family situations, and second, the benefit of a
      specific medical follow-up for TP53 mutation carriers is currently being
      investigated.
FAU - Fresneau, Brice
AU  - Fresneau B
AD  - Laboratoire d'ethique medicale et de medecine legale, Universite Paris Descartes,
      Paris, France. brice.fresneau@etu.upmc.fr
FAU - Brugieres, Laurence
AU  - Brugieres L
FAU - Caron, Olivier
AU  - Caron O
FAU - Moutel, Gregoire
AU  - Moutel G
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20121212
PL  - United States
TA  - J Genet Couns
JT  - Journal of genetic counseling
JID - 9206865
SB  - IM
MH  - Adolescent
MH  - *Ethics
MH  - France
MH  - Genes, p53
MH  - *Genetic Testing
MH  - Humans
MH  - Li-Fraumeni Syndrome/*diagnosis/genetics
MH  - Surveys and Questionnaires
EDAT- 2012/12/13 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/12/13 06:00
PHST- 2012/03/18 00:00 [received]
PHST- 2012/11/21 00:00 [accepted]
PHST- 2012/12/13 06:00 [entrez]
PHST- 2012/12/13 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1007/s10897-012-9556-0 [doi]
PST - ppublish
SO  - J Genet Couns. 2013 Jun;22(3):315-22. doi: 10.1007/s10897-012-9556-0. Epub 2012
      Dec 12.


PMID- 23232957
OWN - NLM
STAT- MEDLINE
DCOM- 20130628
LR  - 20160512
IS  - 1618-2650 (Electronic)
IS  - 1618-2642 (Linking)
VI  - 405
IP  - 5
DP  - 2013 Feb
TI  - MALDI-TOF mass spectrometric determination of intact phospholipids as markers of 
      illegal bovine milk adulteration of high-quality milk.
PG  - 1641-9
LID - 10.1007/s00216-012-6597-z [doi]
AB  - In the dairy industry one of the most common frauds is mixing high-value milk
      (sheep's and goats') with milk of lower value (cows'). This illegal practice has 
      commercial, ethical, and serious sanitary consequences because consumers can be
      exposed to hidden allergens contained in the undeclared cows' milk. Here, we
      investigated the possibility of using matrix-assisted laser-desorption/ionization
      (MALDI)-time of flight (TOF) mass spectrometry (MS) as a rapid, sensitive, and
      accurate technique for detection of milk adulteration by analysis of phospholipid
      profiles. Lipid extracts of pure raw milk, commercial milk, and binary mixtures
      of cows' and goats' milk and cows' and sheep's milk (the concentrations of each
      milk varied from 0 % to 50 %) were analyzed with alpha-cyano-4-chlorocinnamic
      acid as matrix. The abundance ratio of the ions at m/z 703 and m/z 706 was found 
      to be species-correlated and was used as marker of cows' milk in sheep's and
      goats' milk. Furthermore, the procedure could potentially be applied to cheese
      samples, because peaks at m/z 703 and 706 were also found in several commercial
      cheese samples. This approach proved to be an efficient, rapid, and inexpensive
      method of detecting milk fraud.
FAU - Calvano, Cosima D
AU  - Calvano CD
AD  - Dipartimento di Chimica, Universita degli Studi di Bari Aldo Moro, Bari, Italy.
      cosimadamiana.calvano@uniba.it
FAU - De Ceglie, Cristina
AU  - De Ceglie C
FAU - Aresta, Antonella
AU  - Aresta A
FAU - Facchini, Laura A
AU  - Facchini LA
FAU - Zambonin, Carlo G
AU  - Zambonin CG
LA  - eng
PT  - Journal Article
DEP - 20121213
PL  - Germany
TA  - Anal Bioanal Chem
JT  - Analytical and bioanalytical chemistry
JID - 101134327
RN  - 0 (Phospholipids)
SB  - IM
MH  - Animals
MH  - Cattle
MH  - Food Analysis/economics/*methods
MH  - Food Contamination/*analysis
MH  - Goats
MH  - Milk/*chemistry
MH  - Phospholipids/*analysis
MH  - Sheep
MH  - Spectrometry, Mass, Matrix-Assisted Laser
      Desorption-Ionization/economics/*methods
MH  - Time Factors
EDAT- 2012/12/13 06:00
MHDA- 2013/07/03 06:00
CRDT- 2012/12/13 06:00
PHST- 2012/09/10 00:00 [received]
PHST- 2012/11/21 00:00 [accepted]
PHST- 2012/11/16 00:00 [revised]
PHST- 2012/12/13 06:00 [entrez]
PHST- 2012/12/13 06:00 [pubmed]
PHST- 2013/07/03 06:00 [medline]
AID - 10.1007/s00216-012-6597-z [doi]
PST - ppublish
SO  - Anal Bioanal Chem. 2013 Feb;405(5):1641-9. doi: 10.1007/s00216-012-6597-z. Epub
      2012 Dec 13.


PMID- 23232533
OWN - NLM
STAT- MEDLINE
DCOM- 20130620
LR  - 20121212
IS  - 0026-4784 (Print)
IS  - 0026-4784 (Linking)
VI  - 64
IP  - 6
DP  - 2012 Dec
TI  - Oocyte cryopreservation: advances and drawbacks.
PG  - 485-500
AB  - The field of oocyte cryopreservation (OC) had advanced dramatically since the
      first reported birth from cryopreserved oocytes in 1986, with a significant
      increase in pregnancy rates described over the past 5 years due to improvements
      in vitrification technology, a cryopreservation method which virtually means to
      achieve a "glass-like" state through avoidance of ice formation. The potential
      clinical benefits of achieving efficient OC protocols have long been recognized. 
      Specifically, OC can be offered to women who face fertility-threatening
      situations such as therapy for cancer or rheumatologic disease, premature ovarian
      insufficiency, or need for ovarian surgery as a measure to preserve fertility.
      Moreover, many women who plan to delay childbearing are interested in pursuing OC
      in order to protect against age-related fertility decline. For infertility
      practices, efficient OC technology stands to dramatically streamline donor egg
      programs, and is a helpful adjuvant in situations where sperm is unexpectedly
      unavailable at the time of egg retrieval and for couples who do not wish to
      cryopreserve supernumerary embryos created from in vitro fertilization for moral 
      / ethical reasons. This review will describe the history of OC technology over
      the past three decades, discuss clinical circumstances for its implementation,
      and address areas where more research is needed. Given the remarkable
      improvements in pregnancy rates witnessed over the past five years, OC is certain
      to play a much larger role in reproductive medicine over the coming decades.
FAU - Dovey, S
AU  - Dovey S
AD  - Division of Reproductive Endocrinology, Department of Obstetrics, Gynecology and 
      Reproductive Sciences, University of Pittsburgh Medical Center, Magee-Women
      Hospital, Pittsburgh, PA 15213, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - Minerva Ginecol
JT  - Minerva ginecologica
JID - 0400731
SB  - IM
MH  - Animals
MH  - Cell Survival
MH  - Congenital Abnormalities/epidemiology
MH  - Cryopreservation/*methods/trends
MH  - Embryo Disposition
MH  - Equipment Contamination
MH  - Female
MH  - Fertility Preservation
MH  - Fertilization in Vitro
MH  - Humans
MH  - Infant, Newborn
MH  - Infertility, Female/therapy
MH  - Mice
MH  - Oocyte Donation
MH  - Oocyte Retrieval/methods/trends
MH  - Oocytes/*cytology
MH  - Pregnancy
MH  - Pregnancy Outcome
MH  - Pregnancy Rate
MH  - Randomized Controlled Trials as Topic
MH  - Reproductive Behavior
MH  - Reproductive Techniques, Assisted/*trends
MH  - Vitrification
EDAT- 2012/12/13 06:00
MHDA- 2013/06/21 06:00
CRDT- 2012/12/13 06:00
PHST- 2012/12/13 06:00 [entrez]
PHST- 2012/12/13 06:00 [pubmed]
PHST- 2013/06/21 06:00 [medline]
AID - R09123427 [pii]
PST - ppublish
SO  - Minerva Ginecol. 2012 Dec;64(6):485-500.


PMID- 23232483
OWN - NLM
STAT- MEDLINE
DCOM- 20130401
LR  - 20191210
IS  - 0026-4733 (Print)
IS  - 0026-4733 (Linking)
VI  - 67
IP  - 5
DP  - 2012 Oct
TI  - Ultrastructural analysis of different-made staplers' staples.
PG  - 439-44
AB  - AIM: Recently, Chinese-made mechanical staplers with lower price respect to
      American-made ones have been introduced in clinical practice. In literature,
      small case series compare the clinical outcomes of different staplers concluding 
      that the new stapler devices perform as well as the American ones. The aim of
      this study is to compare with an ultrastructural analysis the staples of
      different staplers in order to verify the existence of differences that might
      explain significant price disparity and condition clinical outcomes. METHODS:
      Each stapler was subjected to morphological analysis, energy dispersive X-Ray
      spectroscopy, metal release assessment followed by inductively coupled plasma
      mass spectroscopy. P-values were considered statistically significant when <0.05.
      RESULTS: Autosuture staples have square section whereas the other American one
      and Chinese made staples have round sections. Roughness index and chips presence 
      before and after ageing tests were comparable for all samples except for Ethicon 
      Endo-Surgery stapler. Energy dispersive X-Ray spectroscopy showed that all
      staplers are made of pure Titanium but Ethicon Endo-Surgery staples are made with
      an alloy. Metal release analysis release statistically significant differences
      between samples in simulated body fluid 20 days solution (P=0.002) and in
      Aquaregia at 14 days solution. Discussion. Stapling devices have became routinely
      used in gastrointestinal surgery mainly because of operative time reduction.
      Recently, new Chinese-made mechanical staplers, with significantly lower prices, 
      have been introduced in clinical practice. In literature, there are some studies 
      that compare clinical outcomes of American-made and Chinese-made staplers on
      small groups of patients but doesn't exist any work which consider structural
      differences between traditional and new devices. In our study, for the first
      time, we propose a comparison between two American-made staplers and three
      Chinese-made staplers which evaluate morphology, metal composition and chemical
      staples release. CONCLUSION: Our study suggest that there are some
      ultrastructural differences between commercially available staplers with no
      correlation to price disparity. More studies are needed to confirm our results
      and to verify if our findings could condition clinical outcomes.
FAU - Gentilli, S
AU  - Gentilli S
AD  - Department of Surgery, University of Eastern Piedmont, Novara, Italy.
FAU - Portigliotti, L
AU  - Portigliotti L
FAU - Aronici, M
AU  - Aronici M
FAU - Ferrante, D
AU  - Ferrante D
FAU - Surico, D
AU  - Surico D
FAU - Milanesio, M
AU  - Milanesio M
FAU - Gianotti, V
AU  - Gianotti V
FAU - Gatti, G
AU  - Gatti G
FAU - Addante, A
AU  - Addante A
FAU - Garavoglia, M
AU  - Garavoglia M
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PL  - Italy
TA  - Minerva Chir
JT  - Minerva chirurgica
JID - 0400726
SB  - IM
MH  - Commerce
MH  - Equipment Design
MH  - Microscopy, Electron
MH  - *Surgical Staplers/economics
EDAT- 2012/12/13 06:00
MHDA- 2013/04/02 06:00
CRDT- 2012/12/13 06:00
PHST- 2012/12/13 06:00 [entrez]
PHST- 2012/12/13 06:00 [pubmed]
PHST- 2013/04/02 06:00 [medline]
AID - R06125842 [pii]
PST - ppublish
SO  - Minerva Chir. 2012 Oct;67(5):439-44.


PMID- 23232292
OWN - NLM
STAT- MEDLINE
DCOM- 20130415
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 266
IP  - 3
DP  - 2013 Mar
TI  - A controlled trial of revascularization in acute stroke.
PG  - 871-8
LID - 10.1148/radiol.12120798 [doi]
AB  - PURPOSE: To compare safety and utility of intraarterial revascularization with
      use of stents to no revascularization in patients who either failed to respond to
      intravenous thrombolysis (IVT) or have contraindications to IVT. MATERIALS AND
      METHODS: The case-control study was approved by local ethics committees; all
      patients signed informed consent. One hundred thirty-one patients (74 men; mean
      age, 65.9 years +/- 12.3; range, 25-86 years) with acute ischemic stroke (AIS)
      due to middle cerebral artery (MCA) occlusion were enrolled; 75 underwent IVT. No
      further recanalization therapy was performed in 26 (35%) IVT-treated patients
      with MCA recanalization (group 1). Patients with IVT failure after 60 minutes
      were allocated to endovascular treatment (group 2A) or no further therapy (group 
      2B). Patients with contraindication to IVT were allocated to endovascular
      treatment within 8 hours since AIS onset (group 3A) or to no recanalization
      therapy (group 3B). Neurologic deficit at admission, MCA recanalization,
      symptomatic intracerebral hemorrhage (SICH), and 3-month clinical outcome were
      evaluated. Favorable clinical outcome was defined as modified Rankin scale score 
      0-2 at 3 months after stroke onset. Two-sided Mann-Whitney U test, independent
      samples t test, Fisher exact test, multivariate logistic regression analysis of
      baseline variables, and complete MCA recanalization for the prediction of
      favorable clinical outcome were used for statistical evaluation. RESULTS: Median 
      National Institutes of Health Stroke Scale score at admission was 13.5, 16.0,
      15.5, 15.0, and 16.0 in groups 1, 2A, 2B, 3A, and 3B, respectively (P > .05);
      SICH occurred in one of 26 (3.8%), one of 23 (4.3%), one of 26 (3.8%), one of 31 
      (3.2%), and one of 25 (4.0%) patients, respectively (P > .05). MCA recanalization
      after endovascular treatment was achieved in 50 of 54 (92.6%) patients. Favorable
      outcome was significantly different between groups 2A and 2B (10 of 23 [43.5%]
      and four of 26 [15.4%], respectively; P = .03) and groups 3A and 3B (14 of 31
      [45.2%] and two of 25 [8.0%], respectively; P = .004) and was dependent on MCA
      recanalization (odds ratio, 5.55; P = .006). CONCLUSION: In this controlled
      trial, intraarterial revascularization with stents was an effective and
      safe-effective treatment option in patients with acute MCA occlusion with
      contraindication to IVT or after IVT failure.
FAU - Roubec, Martin
AU  - Roubec M
AD  - Comprehensive Stroke Center, Department of Neurology, Faculty of Medicine,
      Ostrava University and University Hospital Ostrava, 17 Listopadu 1790, CZ-708 52 
      Ostrava-Poruba, Czech Republic.
FAU - Kuliha, Martin
AU  - Kuliha M
FAU - Prochazka, Vaclav
AU  - Prochazka V
FAU - Krajca, Jan
AU  - Krajca J
FAU - Czerny, Daniel
AU  - Czerny D
FAU - Jonszta, Tomas
AU  - Jonszta T
FAU - Krajina, Antonin
AU  - Krajina A
FAU - Sanak, Daniel
AU  - Sanak D
FAU - Langova, Katerina
AU  - Langova K
FAU - Herzig, Roman
AU  - Herzig R
FAU - Skoloudik, David
AU  - Skoloudik D
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20121211
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
EIN - Radiology. 2013 Aug;268(2):614
MH  - Acute Disease
MH  - Adult
MH  - Aged
MH  - *Blood Vessel Prosthesis
MH  - Cerebral Revascularization/*instrumentation
MH  - Czech Republic/epidemiology
MH  - Female
MH  - Humans
MH  - Infarction, Middle Cerebral Artery/diagnostic imaging/*epidemiology/*surgery
MH  - Male
MH  - Middle Aged
MH  - Observer Variation
MH  - Prevalence
MH  - Radiography
MH  - Risk Factors
MH  - *Stents
MH  - Treatment Outcome
EDAT- 2012/12/13 06:00
MHDA- 2013/04/16 06:00
CRDT- 2012/12/13 06:00
PHST- 2012/12/13 06:00 [entrez]
PHST- 2012/12/13 06:00 [pubmed]
PHST- 2013/04/16 06:00 [medline]
AID - radiol.12120798 [pii]
AID - 10.1148/radiol.12120798 [doi]
PST - ppublish
SO  - Radiology. 2013 Mar;266(3):871-8. doi: 10.1148/radiol.12120798. Epub 2012 Dec 11.


PMID- 23231945
OWN - NLM
STAT- MEDLINE
DCOM- 20140501
LR  - 20130913
IS  - 1758-5341 (Electronic)
IS  - 0016-9013 (Linking)
VI  - 53
IP  - 5
DP  - 2013 Oct
TI  - Management of sexual expression in long-term care: ombudsmen's perspectives.
PG  - 780-9
LID - 10.1093/geront/gns162 [doi]
AB  - PURPOSE: This study investigates sexual expression management in long-term care
      settings based on cases requiring intervention from ombudsmen. Although the
      literature frequently mentions a lack of policies governing sexual expression in 
      these settings, there is little information available on management of situations
      when they occur. This study addresses these missing elements through the
      perspective of resident advocates. DESIGN AND METHODS: 31 in-depth interviews
      using a multiple case study approach were conducted with long-term care ombudsmen
      in 6 states. A thematic analysis was performed on the interview transcripts.
      RESULTS: Ombudsmen intervened in cases based on dilemma or conflict due to risk, 
      risk associated with dementing illness, limited knowledge, privacy, and values.
      The theoretical framework of the total institution was utilized to interpret the 
      results. IMPLICATIONS: The results underscored the importance of resident
      advocates to support residents' rights. This research also highlights the
      importance of workforce training and examination of the institutional impact on
      resident sexual expression. Formulation of standards of practice for ethically
      complex situations is also critically important.
FAU - Cornelison, Laci J
AU  - Cornelison LJ
AD  - *Address correspondence to Laci J. Cornelison, Center on Aging, Kansas State
      University, 103 Leasure Hall, Manhattan, KS 66506. E-mail: ljh8484@ksu.edu.
FAU - Doll, Gayle M
AU  - Doll GM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121210
PL  - United States
TA  - Gerontologist
JT  - The Gerontologist
JID - 0375327
SB  - IM
MH  - *Homes for the Aged
MH  - Humans
MH  - Long-Term Care
MH  - *Nursing Homes
MH  - *Patient Advocacy
MH  - *Patient Rights
MH  - Patient Safety
MH  - Privacy
MH  - Sex Offenses
MH  - *Sexual Behavior
MH  - Sexually Transmitted Diseases/prevention & control
MH  - United States
OTO - NOTNLM
OT  - Intimacy
OT  - Nursing homes
OT  - Resident advocates
EDAT- 2012/12/13 06:00
MHDA- 2014/05/03 06:00
CRDT- 2012/12/13 06:00
PHST- 2012/12/13 06:00 [entrez]
PHST- 2012/12/13 06:00 [pubmed]
PHST- 2014/05/03 06:00 [medline]
AID - gns162 [pii]
AID - 10.1093/geront/gns162 [doi]
PST - ppublish
SO  - Gerontologist. 2013 Oct;53(5):780-9. doi: 10.1093/geront/gns162. Epub 2012 Dec
      10.


PMID- 23231566
OWN - NLM
STAT- MEDLINE
DCOM- 20130214
LR  - 20121212
IS  - 1532-5415 (Electronic)
IS  - 0002-8614 (Linking)
VI  - 60
IP  - 12
DP  - 2012 Dec
TI  - Ethical challenges in evidence-based management of an elderly adult with cancer
      without decision-making capacity.
PG  - 2379-80
LID - 10.1111/jgs.12010 [doi]
FAU - Ramaswamy, Ravishankar
AU  - Ramaswamy R
LA  - eng
PT  - Case Reports
PT  - Letter
PL  - United States
TA  - J Am Geriatr Soc
JT  - Journal of the American Geriatrics Society
JID - 7503062
SB  - IM
MH  - Aged
MH  - Cognition Disorders/*complications
MH  - Decision Making/*ethics
MH  - Humans
MH  - Male
MH  - *Mental Competency
MH  - Prostatic Neoplasms/complications/*therapy
MH  - Withholding Treatment/*ethics
EDAT- 2012/12/13 06:00
MHDA- 2013/02/15 06:00
CRDT- 2012/12/13 06:00
PHST- 2012/12/13 06:00 [entrez]
PHST- 2012/12/13 06:00 [pubmed]
PHST- 2013/02/15 06:00 [medline]
AID - 10.1111/jgs.12010 [doi]
PST - ppublish
SO  - J Am Geriatr Soc. 2012 Dec;60(12):2379-80. doi: 10.1111/jgs.12010.


PMID- 23231472
OWN - NLM
STAT- MEDLINE
DCOM- 20130826
LR  - 20130307
IS  - 1557-9034 (Electronic)
IS  - 1092-6429 (Linking)
VI  - 23
IP  - 3
DP  - 2013 Mar
TI  - Clipless versus conventional laparoscopic cholecystectomy.
PG  - 237-9
LID - 10.1089/lap.2012.0387 [doi]
AB  - Abstract Laparoscopic cholecystectomy has been the gold standard technique for
      cholecystectomy and has proven more effective than the conventional open
      technique. The laparoscopic technique utilizes surgical clips for cystic duct
      occlusion, which come with their own set of complications. With the advent of new
      vessel and duct sealing technology, alternative energy instruments have been
      explored for the occlusion of the cystic duct without the use of clips. The
      Harmonic((R)) scalpel (Ethicon Endo-Surgery, Cincinnati, OH) has become one of
      the more widely used instruments. In this retrospective study, 208 patients
      received surgical clip placement or the Harmonic scalpel was used for cystic duct
      occlusion. The postoperative complications were documented, and rates were
      calculated for outpatient follow-up, for re-admission, and specifically for the
      complications of a bile leak. When adjusted for the cause of bile leak (cystic
      duct versus common bile duct versus accessory duct), the use of the Harmonic
      scalpel versus clip placement had comparable rates of bile leak at 1.75% and
      0.66%, respectively. The use of the Harmonic scalpel is deemed safe and
      comparable to clip placement at the discretion of the surgeon for cystic duct
      ligation. Further research with larger homogeneous studies and assessments of
      cost-effectiveness would further enhance the increasing use of the Harmonic
      scalpel in laparoscopic cholecystectomy.
FAU - Wills, Edward
AU  - Wills E
AD  - Lincoln Memorial University-DeBusk College of Osteopathic Medicine, Harrogate,
      Tennessee, USA. Edward.wills@lmunet.edu
FAU - Crawford, George
AU  - Crawford G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20121211
PL  - United States
TA  - J Laparoendosc Adv Surg Tech A
JT  - Journal of laparoendoscopic & advanced surgical techniques. Part A
JID - 9706293
SB  - IM
MH  - Cholecystectomy, Laparoscopic/*instrumentation/*methods
MH  - Cholestasis/*surgery
MH  - *Cystic Duct
MH  - Humans
MH  - Retrospective Studies
EDAT- 2012/12/13 06:00
MHDA- 2013/08/27 06:00
CRDT- 2012/12/13 06:00
PHST- 2012/12/13 06:00 [entrez]
PHST- 2012/12/13 06:00 [pubmed]
PHST- 2013/08/27 06:00 [medline]
AID - 10.1089/lap.2012.0387 [doi]
PST - ppublish
SO  - J Laparoendosc Adv Surg Tech A. 2013 Mar;23(3):237-9. doi: 10.1089/lap.2012.0387.
      Epub 2012 Dec 11.


PMID- 23231434
OWN - NLM
STAT- MEDLINE
DCOM- 20131217
LR  - 20121212
IS  - 1558-1527 (Electronic)
IS  - 1558-1527 (Linking)
VI  - 83
IP  - 4
DP  - 2012 Apr 30
TI  - Development of the AOA Code of Ethics and Standards of Professional Conduct.
PG  - 123-4
FAU - Paramore, James
AU  - Paramore J
FAU - Berman, Morris
AU  - Berman M
FAU - Eichhorst, Thomas
AU  - Eichhorst T
LA  - eng
PT  - Editorial
DEP - 20120430
PL  - United States
TA  - Optometry
JT  - Optometry (St. Louis, Mo.)
JID - 100912421
SB  - IM
MH  - *Clinical Competence
MH  - *Codes of Ethics
MH  - *Ethics, Professional
MH  - Humans
MH  - Optometry/*ethics
MH  - Physician-Patient Relations/*ethics
MH  - United States
EDAT- 2012/12/13 06:00
MHDA- 2013/12/18 06:00
CRDT- 2012/12/13 06:00
PHST- 2012/12/13 06:00 [entrez]
PHST- 2012/12/13 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
PST - epublish
SO  - Optometry. 2012 Apr 30;83(4):123-4.


PMID- 23230634
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20121212
IS  - 1145-0762 (Print)
IS  - 1145-0762 (Linking)
VI  - 23
IP  - 3-4
DP  - 2012 Sep-Dec
TI  - Are clarifications on feeding and hydration in PVS needed by Catholic
      authorities?
PG  - 179-88, 198-9
AB  - Ever since the possibility of keeping a person on advanced life support the
      Catholic Church has been concerned with the rights of the individual to a
      dignified death and the right to refuse treatment. This right has traditionally
      and in documents of the Church been extended to the family in the absence of
      specified wishes of the patient. Again, since the controversies on patients in a 
      persistent vegetative state (PVS) have come to public knowledge, especially with 
      the case of Terry Schiavo, and more recently, in Italy, the case of Eluana
      Englaro, people have been confused about the issue of what constitutes
      extraordinary treatment. This article focuses on the history of advanced life
      support and extraordinary treatment, with special reference to PVS and attempts
      to conclude that given the information already available decision to withdraw
      such care, even if in principle it may be considered ordinary, can be pursued
      within the same teachings and should therefore not pose problems to medical
      personnel once a proper legal and ethical procedure is followed. Failure to
      acknowledge such history and facts is indeed admitting a failure of bioethics as 
      a futile subject.
FAU - Mallia, Pierre
AU  - Mallia P
AD  - Bioethics Research Programme, Faculty of Medicine & Surgery, Medical School Mater
      Dei Hospital, University of Malta, Msida, Malta. pierre.mallia@um.edu.mt
LA  - eng
PT  - Journal Article
PL  - France
TA  - J Int Bioethique
JT  - Journal international de bioethique = International journal of bioethics
JID - 9015754
SB  - IM
MH  - *Catholicism
MH  - Humans
MH  - *Life Support Care
MH  - Medical Futility
MH  - Persistent Vegetative State/*therapy
MH  - Right to Die/ethics/legislation & jurisprudence
MH  - Withholding Treatment/ethics/legislation & jurisprudence
EDAT- 2012/12/13 06:00
MHDA- 2013/03/13 06:00
CRDT- 2012/12/13 06:00
PHST- 2012/12/13 06:00 [entrez]
PHST- 2012/12/13 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
PST - ppublish
SO  - J Int Bioethique. 2012 Sep-Dec;23(3-4):179-88, 198-9.


PMID- 23230633
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20191112
IS  - 1145-0762 (Print)
IS  - 1145-0762 (Linking)
VI  - 23
IP  - 3-4
DP  - 2012 Sep-Dec
TI  - [Contributions of training in biomedical ethics. Investigations, considerations
      and prospects].
PG  - 167-77, 197-8
AB  - The testimonies of healthcare professionals who have received introductory
      training in biomedial ethics show a perceived improvement in their competence in 
      managing complex situations that involve ethical stakes. The resources acquired
      in this way should make it possible to prevent and reduce the appearance of moral
      distress, a phenomenon the consequences and persistence of which can lead to
      burnout and to giving up the profession. These observations encourage
      establishments to reinforce the resources intended for ethical awareness courses 
      for their fellow workers.
FAU - Waelchli, M
AU  - Waelchli M
AD  - Commission d'ethique des hopitaux de la Riviera et du Chablais, Vevey, Suisse.
      maude.waelchli@hopital-riviera.ch
FAU - Foppa, C
AU  - Foppa C
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Apports d'une formation en ethique biomedicale investigations, considerations et 
      perspectives.
PL  - France
TA  - J Int Bioethique
JT  - Journal international de bioethique = International journal of bioethics
JID - 9015754
SB  - IM
MH  - Attitude of Health Personnel
MH  - *Clinical Competence
MH  - Ethics, Clinical/*education
MH  - Humans
EDAT- 2012/12/13 06:00
MHDA- 2013/03/13 06:00
CRDT- 2012/12/13 06:00
PHST- 2012/12/13 06:00 [entrez]
PHST- 2012/12/13 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
AID - 10.3917/jib.233.0167 [doi]
PST - ppublish
SO  - J Int Bioethique. 2012 Sep-Dec;23(3-4):167-77, 197-8. doi: 10.3917/jib.233.0167.


PMID- 23230632
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20191112
IS  - 1145-0762 (Print)
IS  - 1145-0762 (Linking)
VI  - 23
IP  - 3-4
DP  - 2012 Sep-Dec
TI  - [Ethical intervention in pragmatic regime].
PG  - 149-65, 197
AB  - This article analyzes the impact of the neo-pragmatist turn in social sciences
      from the point of view of the method of ethical intervention. It focuses
      specifically on the idea of building a "learning community" as the horizon for
      strengthening participative 'capacitation'. It finally points at the limits of
      such a perspective, from the point of view of institutional building of new
      subjectivities through and beyond the practices proposed by ethical
      interventions.
FAU - Maesschalck, Marc
AU  - Maesschalck M
AD  - Universite Catholique de Louvain, Centre de Philosophie du Droit.
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - L'intervention ethique en regime pragmatique.
PL  - France
TA  - J Int Bioethique
JT  - Journal international de bioethique = International journal of bioethics
JID - 9015754
SB  - IM
MH  - Ethical Analysis
MH  - *Ethical Theory
MH  - Humans
MH  - *Social Sciences
EDAT- 2012/12/13 06:00
MHDA- 2013/03/13 06:00
CRDT- 2012/12/13 06:00
PHST- 2012/12/13 06:00 [entrez]
PHST- 2012/12/13 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
AID - 10.3917/jib.233.0149 [doi]
PST - ppublish
SO  - J Int Bioethique. 2012 Sep-Dec;23(3-4):149-65, 197. doi: 10.3917/jib.233.0149.


PMID- 23230631
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20191112
IS  - 1145-0762 (Print)
IS  - 1145-0762 (Linking)
VI  - 23
IP  - 3-4
DP  - 2012 Sep-Dec
TI  - [From the pragmatic to pragmatism: what are the stakes for training in ethics?].
PG  - 123-48, 196
AB  - The contemporary evolution of the request and the recourse for ethics in the
      health field questions the models of ethics training. Indeed the stake is no more
      to train actors able of producing a moral speech on the practices but, in a
      destabilized context, to accompany them in the development of new practices in
      professional situation. This pragmatic turn in health ethics requires more
      active, reflective and contextual models of training, needing new links between
      training places and care practices. This paper is about theoretical foundations
      of such an ethics pedagogy, and about its stakes in terms of
      re-institutionalization. Pragmatism, and more particularly the approach of John
      Dewey, will be mobilized here to found educational practices needed by such an
      ethics pedagogy (an experiential, reflective and collective learning), but also
      to consider issues concerning training device linked to such a learning. On this 
      point, the philosophy of integrative block-release training is investigated as a 
      way to develop future professional competences, even if the last part of this
      text will insist on the reflective governance such an alternation requires and on
      the "re-institutionalization of the ethics pedagogy" that the latter generates.
FAU - Aiguier, Gregory
AU  - Aiguier G
AD  - Centre d'Ethique Medicale et Faculte Libre de Medecine de l'Universite Catholique
      de Lille, France.
FAU - Le Berre, Rozenn
AU  - Le Berre R
FAU - Vanpee, Dominique
AU  - Vanpee D
FAU - Cobbaut, Jean-Philippe
AU  - Cobbaut JP
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Du pragmatique au pragmatisme : quels enjeux pour la formation a l'ethique?
PL  - France
TA  - J Int Bioethique
JT  - Journal international de bioethique = International journal of bioethics
JID - 9015754
SB  - IM
MH  - Bioethics/*education
MH  - Ethical Analysis
MH  - *Ethical Theory
MH  - Humans
EDAT- 2012/12/13 06:00
MHDA- 2013/03/13 06:00
CRDT- 2012/12/13 06:00
PHST- 2012/12/13 06:00 [entrez]
PHST- 2012/12/13 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
AID - 10.3917/jib.233.0123 [doi]
PST - ppublish
SO  - J Int Bioethique. 2012 Sep-Dec;23(3-4):123-48, 196. doi: 10.3917/jib.233.0123.


PMID- 23230630
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20191112
IS  - 1145-0762 (Print)
IS  - 1145-0762 (Linking)
VI  - 23
IP  - 3-4
DP  - 2012 Sep-Dec
TI  - [Continuing education in ethics: from clinical ethics to institutional ethics].
PG  - 111-22, 195
AB  - UNLABELLED: The mandate of the Ethics Committee of the Conseil de medecins,
      dentistes et pharmaciens (CMDP) at the Centre hospitalier universitaire de
      Sherbrooke (CHUS), Sherbrooke, Quebec is three-fold: to guide the clinical
      decision; to address the institutional ethical function; to create the program
      for continuing education in ethics (Formation ethique continue or FEC). Might FEC
      be the means of bridging from individual ethics to institutional ethics at a
      hospital? AIM: To take the FEC perspectives considered appropriate for doctors
      and consider them for validation or disproving in the context of those of other
      professionals. PROPOSED METHOD: Situate the proposed FEC mandate in a reference
      framework to evaluate (or triangulate) the clinical decision and the
      institutional ethic. CONVICTION: Sustainable professional development for doctors
      (DPD) includes ethics; it cannot be ignored. Without constant attention to
      upgrading one's abilities in professional ethics, these suffer the same fate as
      other professional aptitudes and competences (for example, techniques and
      scientific knowledge): decay.
FAU - Brazeau-Lamontagne, Lucie
AU  - Brazeau-Lamontagne L
AD  - Universite de Sherbrooke, CHUS-FMUS, Departement de radiologie diagnostique,
      3001, 12e Avenue Nord, Fleurimont, Quebec, Canada J1H 5N4.
      Lucie.Brazeau.Lamontagne@USherbrooke.ca
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - La formation ethique continue: de l'ethique clinique a l'ethique
      institutionnelle.
PL  - France
TA  - J Int Bioethique
JT  - Journal international de bioethique = International journal of bioethics
JID - 9015754
SB  - IM
MH  - *Education, Continuing
MH  - Ethics, Clinical/*education
MH  - Ethics, Institutional/*education
MH  - Humans
MH  - Quebec
EDAT- 2012/12/13 06:00
MHDA- 2013/03/13 06:00
CRDT- 2012/12/13 06:00
PHST- 2012/12/13 06:00 [entrez]
PHST- 2012/12/13 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
AID - 10.3917/jib.233.0111 [doi]
PST - ppublish
SO  - J Int Bioethique. 2012 Sep-Dec;23(3-4):111-22, 195. doi: 10.3917/jib.233.0111.


PMID- 23230629
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20191112
IS  - 1145-0762 (Print)
IS  - 1145-0762 (Linking)
VI  - 23
IP  - 3-4
DP  - 2012 Sep-Dec
TI  - [First analysis of the deployment of the ethical approach in the field of mental 
      health in the Nord Pas-de-Calais region].
PG  - 95-110, 194
AB  - For 3 years, the Regional Federation of Mental Health Research (F2RSM) has led a 
      space ethics reflexion Department of mental health (ERESM) to federate structures
      that ethical institutions and mental health services have been creating in the
      Nord-Pas de Calais. This approach is, in many ways, revealing issues that involve
      the institutionalisation of ethical reflection in care facilities. In this
      article, after referring to the major developments in this field, we describe the
      conditions for the emergence of ethical bodies in the region. Through the choice 
      of development and operation of the ethical reflexion department, we highlight a 
      number of points of attention that illustrate the complex articulation between
      institutional expectations and concerns of professionals. The trajectory of the
      ERESM is thus revealed as a process of reflective learning open to all
      stakeholders, providers and users of mental health.
FAU - Boury, Dominique
AU  - Boury D
AD  - Centre d'ethique medicale et Faculte Libre de Medecine de l'Universite Catholique
      de Lille.
FAU - Francois, Guillaume
AU  - Francois G
FAU - Danel, Thierry
AU  - Danel T
FAU - Cobbaut, Jean-Philippe
AU  - Cobbaut JP
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Premiere analyse du deploiement de la demarche ethique dans le champ de la sante 
      mentale en region Nord Pas-de-Calais.
PL  - France
TA  - J Int Bioethique
JT  - Journal international de bioethique = International journal of bioethics
JID - 9015754
SB  - IM
MH  - France
MH  - Humans
MH  - Mental Health Services/*ethics
EDAT- 2012/12/13 06:00
MHDA- 2013/03/13 06:00
CRDT- 2012/12/13 06:00
PHST- 2012/12/13 06:00 [entrez]
PHST- 2012/12/13 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
AID - 10.3917/jib.233.0095 [doi]
PST - ppublish
SO  - J Int Bioethique. 2012 Sep-Dec;23(3-4):95-110, 194. doi: 10.3917/jib.233.0095.


PMID- 23230628
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20191112
IS  - 1145-0762 (Print)
IS  - 1145-0762 (Linking)
VI  - 23
IP  - 3-4
DP  - 2012 Sep-Dec
TI  - ["Espace national de reflexion ethique sur la maladie d'Alzheimer--EREMA".
      Another approach to Alzheimer's disease and ethical responsibility].
PG  - 87-94, 193
AB  - The creation in 2010 of a national ethical area on Alzheimer disease illustrates 
      the evolution in the French context towards an institutionalization of ethical
      approach concerning chronic diseases and long term care. This paper presents the 
      background of such a national area, how it works, its objectives and two concrete
      outputs: the charter "Alzheimer Ethics & Society 2011" and the advice "Alzheimer,
      ethics and society", published in September 2012.
FAU - Hirsch, Emmanuel
AU  - Hirsch E
AD  - L'universite Paris-Sud.
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - L'espace national de reflexion ethique sur la maladie d'Alzheimer. Une autre
      approche de la maladie et de la responsabilite ethique.
PL  - France
TA  - J Int Bioethique
JT  - Journal international de bioethique = International journal of bioethics
JID - 9015754
SB  - IM
MH  - *Alzheimer Disease
MH  - Ethics, Medical
MH  - *Health Policy
MH  - Humans
MH  - *Long-Term Care
EDAT- 2012/12/13 06:00
MHDA- 2013/03/13 06:00
CRDT- 2012/12/13 06:00
PHST- 2012/12/13 06:00 [entrez]
PHST- 2012/12/13 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
AID - 10.3917/jib.233.0087 [doi]
PST - ppublish
SO  - J Int Bioethique. 2012 Sep-Dec;23(3-4):87-94, 193. doi: 10.3917/jib.233.0087.


PMID- 23230627
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20191112
IS  - 1145-0762 (Print)
IS  - 1145-0762 (Linking)
VI  - 23
IP  - 3-4
DP  - 2012 Sep-Dec
TI  - [How to institutionalize the ethical approach. The example of geriatric care].
PG  - 67-86, 192-3
AB  - This paper aims at showing how strengthening and adapting the system of care to
      the needs and expectations of older people today requires a change in the way to 
      conceive the ethical approach. If clinical ethics remains a fundamental tool of
      the ethical approach in order to identify and to understand the ethical issues of
      a geriatric practice both complex and uncertain, as well as to adequately
      articulate the patient's expectations, the technical quality of care and the
      organization of a complex support, this area of care manifests the need for an
      institutionalization of the ethical approach. To be relevant, legitimate and
      effective, the ethical approach must not only be opened to the organizational
      aspects of care but also be able to fit into the institutional dynamics.
FAU - Cobbaut, Jean-Philippe
AU  - Cobbaut JP
AD  - Centre d'ethique medicale du Departement d'ethique et Faculte Libre de Medecine
      de l'Universite Catholique de Lille, France jean-philippe.cobbaut@icl-lille.fr
FAU - Hennion, Caroline
AU  - Hennion C
FAU - Boitte, Pierre
AU  - Boitte P
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Quelle institutionalisation de la demarche ethique? L'exemple des soins
      geriatriques.
PL  - France
TA  - J Int Bioethique
JT  - Journal international de bioethique = International journal of bioethics
JID - 9015754
SB  - IM
MH  - *Ethics, Institutional
MH  - *Ethics, Medical
MH  - *Geriatrics
MH  - Humans
MH  - *Philosophy, Medical
EDAT- 2012/12/13 06:00
MHDA- 2013/03/13 06:00
CRDT- 2012/12/13 06:00
PHST- 2012/12/13 06:00 [entrez]
PHST- 2012/12/13 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
AID - 10.3917/jib.233.0067 [doi]
PST - ppublish
SO  - J Int Bioethique. 2012 Sep-Dec;23(3-4):67-86, 192-3. doi: 10.3917/jib.233.0067.


PMID- 23230626
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20121212
IS  - 1145-0762 (Print)
IS  - 1145-0762 (Linking)
VI  - 23
IP  - 3-4
DP  - 2012 Sep-Dec
TI  - Moral case deliberation in an academic hospital in the Netherlands. Tensions
      between theory and practice.
PG  - 53-66, 191-2
AB  - In this article we describe the process of developing an ethics support service
      in a Dutch academic hospital by means of implementing moral case deliberation
      (MCD). In MCD, health care professionals discuss their moral issues pertaining to
      a real case in order to come to mutual understanding and/or a shared idea of what
      is best to do and in which way. MCD is inspired by the philosophy of dialogical
      and hermeneutic ethics. Equal dialogue and critical constructive reflection are
      both important aims and means of MCD. This requires equality of perspectives,
      time to deliberate about values and considerations, and active involvement of all
      participants (ownership). However, within the context of an academic hospital,
      these conditions are not evident, given the prevalence of power and hierarchy,
      the need for efficiency and time management, and the emphasis on experts' advice 
      instead of joint responsibility. This paper introduces the core features of the
      philosophical background of MCD and describes ways of dealing with some tensions 
      between MCD's philosophical inspirations and the practical context of an academic
      hospital while implementing MCD. The paper shows that these philosophical
      inspirations can be helpful in the cooperation with an academic hospital when
      implementing MCD together. This joint process of making MCD meaningful and useful
      for the practice while dealing with different tensions, is as important as
      offering high quality MCD sessions.
FAU - Stolper, Margreet
AU  - Stolper M
AD  - Free University medical centre (VUmc), EMGO+, Amsterdam, the Netherlands.
      m.stolper@vumc.nl
FAU - Metselaar, Suzanne
AU  - Metselaar S
FAU - Molewijki, Bert
AU  - Molewijki B
FAU - Widdershoven, Guy
AU  - Widdershoven G
LA  - eng
PT  - Journal Article
PL  - France
TA  - J Int Bioethique
JT  - Journal international de bioethique = International journal of bioethics
JID - 9015754
SB  - IM
MH  - Academic Medical Centers
MH  - *Ethics, Clinical
MH  - Humans
MH  - Medical Staff, Hospital/psychology
MH  - *Morals
MH  - Netherlands
MH  - Nursing Staff, Hospital/psychology
EDAT- 2012/12/13 06:00
MHDA- 2013/03/13 06:00
CRDT- 2012/12/13 06:00
PHST- 2012/12/13 06:00 [entrez]
PHST- 2012/12/13 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
PST - ppublish
SO  - J Int Bioethique. 2012 Sep-Dec;23(3-4):53-66, 191-2.


PMID- 23230625
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20191112
IS  - 1145-0762 (Print)
IS  - 1145-0762 (Linking)
VI  - 23
IP  - 3-4
DP  - 2012 Sep-Dec
TI  - [From using a model of decisional clinical ethics to constituting a place for
      collective learning. The experience of a reflexive seminar between healthcare
      professionals and ethics researchers].
PG  - 33-52, 190
AB  - This paper shows how an experimental clinical ethics device, proposed by
      researchers in ethics to intensive care units professionals, has created a
      collective learning context. The outcome of such a collective learning has been
      the progressive working-out, from the clinical and care practice, of a given
      clinical ethics grid into a more intensive care units context adapted grid. Some 
      comments are made about the importance to subjectivize a clinical ethics
      approach, about the collective learning device installed throughout the joint
      health care professionals--researchers in ethics seminar and about the need to
      institutionalize ethics.
FAU - Boitte, Pierre
AU  - Boitte P
AD  - Centre d'ethique medicale du Departement d'ethique et Faculte Libre de Medecine
      de l'Universite Catholique de Lille, France. pierre.boitte@icl-lille.fr
FAU - Jacquemin, Dominique
AU  - Jacquemin D
FAU - Vanderlinden, Thierry
AU  - Vanderlinden T
FAU - Nuttens, Olivier
AU  - Nuttens O
FAU - Cobbaut, Jean-Philippe
AU  - Cobbaut JP
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - De l'usage d'une grille d'ethique clinique decisionnelle a la constitution d'un
      lieu d'apprentissage collectif. L'experience d'un seminaire reflexif entre
      professionnels de sante et chercheurs en ethique.
PL  - France
TA  - J Int Bioethique
JT  - Journal international de bioethique = International journal of bioethics
JID - 9015754
SB  - IM
MH  - Decision Making
MH  - *Ethicists
MH  - Ethics, Clinical/*education
MH  - *Health Personnel
MH  - Humans
EDAT- 2012/12/13 06:00
MHDA- 2013/03/13 06:00
CRDT- 2012/12/13 06:00
PHST- 2012/12/13 06:00 [entrez]
PHST- 2012/12/13 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
AID - 10.3917/jib.233.0033 [doi]
PST - ppublish
SO  - J Int Bioethique. 2012 Sep-Dec;23(3-4):33-52, 190. doi: 10.3917/jib.233.0033.


PMID- 23230624
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20191112
IS  - 1145-0762 (Print)
IS  - 1145-0762 (Linking)
VI  - 23
IP  - 3-4
DP  - 2012 Sep-Dec
TI  - [Towards a reflexive governance of the ethical approach in healthcare
      institutions].
PG  - 15-31, 189-90
AB  - We stand up in this article for bioethics as practice, as attest since the 1980
      the evolution of theoretical work in bioethics towards a growing need of
      contextualization. This development justifies for us to work out a context
      sensitive, pragmatist and reflective ethics as a learning process. Such an idea
      of ethics allows to understand the transition from hospital ethics committes and 
      clinical ethics consultation towards a more integrative institutional perspective
      that we defend here. This institutionalization of clinical ethics support
      services has to be accompanied by a reflective governance of this process. The
      papers of this issue aim to take into account in a various way this evolution of 
      the bioethical field, both practical, methodological, institutional, educational 
      and theoretical.
FAU - Boitte, Pierre
AU  - Boitte P
AD  - Centre d'ethique medicale du Departement d'ethique et Faculte Libre de Medecine
      de l'Universite Catholique de Lille, France. Pierre.Boitte@icl-lille.fr
FAU - Cobbaut, Jean-Philippe
AU  - Cobbaut JP
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Vers une gouvernance reflexive de la demarche ethique dans les institutions de
      soins.
PL  - France
TA  - J Int Bioethique
JT  - Journal international de bioethique = International journal of bioethics
JID - 9015754
SB  - IM
MH  - *Ethical Theory
MH  - Ethics Consultation
MH  - *Ethics, Clinical
MH  - Humans
EDAT- 2012/12/13 06:00
MHDA- 2013/03/13 06:00
CRDT- 2012/12/13 06:00
PHST- 2012/12/13 06:00 [entrez]
PHST- 2012/12/13 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
AID - 10.3917/jib.233.0015 [doi]
PST - ppublish
SO  - J Int Bioethique. 2012 Sep-Dec;23(3-4):15-31, 189-90. doi: 10.3917/jib.233.0015.


PMID- 23230460
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130704
LR  - 20211021
IS  - 1941-5893 (Print)
IS  - 1941-5893 (Linking)
VI  - 5
IP  - supp
DP  - 2012 Aug
TI  - Recruitment and retention monitoring: facilitating the mission of the National
      Institute of Neurological Disorders and Stroke (NINDS).
PG  - 14-9
AB  - It is commonly accepted that inefficient recruitment and inadequate retention
      continue to threaten the completion of clinical trials intended to reduce the
      public health burden of neurological disease. This article will discuss the
      scientific, economic, and ethical implications of failure to recruit and retain
      adequate samples in clinical trials, including the consequences of failing to
      recruit adequately diverse samples. We will also discuss the more common
      challenges and barriers to efficient and effective recruitment and retention, and
      the impact these have on successful clinical trial planning. We will explain the 
      newly established efforts within National Institute of Neurological Disorders and
      Stroke (NINDS) to monitor recruitment and retention with well-defined metrics and
      implementation of grant awards that include feasibility milestones for continued 
      funding. Finally, we will describe our efforts to address some of the common
      challenges to recruitment and retention through assistance to investigators and
      coordinators with evidence-based support, tools, and resources for planning and
      strategizing recruitment and retention as well as a trans-NIH effort to improve
      awareness of clinical research in the general public.
FAU - Roberts, J
AU  - Roberts J
FAU - Waddy, S
AU  - Waddy S
FAU - Kaufmann, P
AU  - Kaufmann P
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Vasc Interv Neurol
JT  - Journal of vascular and interventional neurology
JID - 101511381
PMC - PMC3517027
EDAT- 2012/12/12 06:00
MHDA- 2012/12/12 06:01
CRDT- 2012/12/12 06:00
PHST- 2012/12/12 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2012/12/12 06:01 [medline]
PST - ppublish
SO  - J Vasc Interv Neurol. 2012 Aug;5(supp):14-9.


PMID- 23229374
OWN - NLM
STAT- MEDLINE
DCOM- 20140122
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 3
DP  - 2013 Sep
TI  - Towards a richer debate on tissue engineering: a consideration on the basis of
      NEST-ethics.
PG  - 963-81
LID - 10.1007/s11948-012-9419-y [doi]
AB  - In their 2007 paper, Swierstra and Rip identify characteristic tropes and
      patterns of moral argumentation in the debate about the ethics of new and
      emerging science and technologies (or "NEST-ethics"). Taking their NEST-ethics
      structure as a starting point, we considered the debate about tissue engineering 
      (TE), and argue what aspects we think ought to be a part of a rich and
      high-quality debate of TE. The debate surrounding TE seems to be predominantly a 
      debate among experts. When considering the NEST-ethics arguments that deal
      directly with technology, we can generally conclude that consequentialist
      arguments are by far the most prominently featured in discussions of TE. In
      addition, many papers discuss principles, rights and duties relevant to aspects
      of TE, both in a positive and in a critical sense. Justice arguments are only
      sporadically made, some "good life" arguments are used, others less so (such as
      the explicit articulation of perceived limits, or the technology as a
      technological fix for a social problem). Missing topics in the discussion, at
      least from the perspective of NEST-ethics, are second "level" arguments-those
      referring to techno-moral change connected to tissue engineering. Currently, the 
      discussion about tissue engineering mostly focuses on its so-called "hard
      impacts"-quantifiable risks and benefits of the technology. Its "soft
      impacts"-effects that cannot easily be quantified, such as changes to experience,
      habits and perceptions, should receive more attention.
FAU - Oerlemans, A J M
AU  - Oerlemans AJ
AD  - Scientific Institute for Quality of Healthcare, Radboud University Nijmegen
      Medical Centre, Nijmegen, The Netherlands. a.oerlemans@iq.umcn.nl
FAU - van Hoek, M E C
AU  - van Hoek ME
FAU - van Leeuwen, E
AU  - van Leeuwen E
FAU - van der Burg, S
AU  - van der Burg S
FAU - Dekkers, W J M
AU  - Dekkers WJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121115
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Ethical Theory
MH  - Human Rights
MH  - Humans
MH  - Moral Obligations
MH  - Quality of Life
MH  - Science/*ethics
MH  - *Social Justice
MH  - *Social Responsibility
MH  - Technology/*ethics
MH  - Tissue Engineering/*ethics
EDAT- 2012/12/12 06:00
MHDA- 2014/01/23 06:00
CRDT- 2012/12/12 06:00
PHST- 2012/06/12 00:00 [received]
PHST- 2012/11/06 00:00 [accepted]
PHST- 2012/12/12 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2014/01/23 06:00 [medline]
AID - 10.1007/s11948-012-9419-y [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Sep;19(3):963-81. doi: 10.1007/s11948-012-9419-y. Epub 2012 
      Nov 15.


PMID- 23229209
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20121211
IS  - 0019-557X (Print)
IS  - 0019-557X (Linking)
VI  - 56
IP  - 3
DP  - 2012 Jul-Sep
TI  - From guidelines to ground reality: maximizing the benefits of IDRV in the fourth 
      year of its implementation.
PG  - 187-8
LID - 10.4103/0019-557X.104207 [doi]
AB  - The updated Thai Red Cross Intradermal (TRC-ID) regimen is the most effective
      strategy for India as it uses only 40% volume of vaccines in comparison with
      intramuscular (IM) when 0.5 ml vial is used and 20% when 1-ml vial is used;
      hence, the cost-effectiveness of intradermal (ID) regimen further increases when 
      1 ml vial is used. To improve the compliance of ID, postexposure prophylaxis
      (PEP) given free of cost is the ideal solution. For availability and avoiding
      administrative delays, universal ID delivery of PEP is the answer. ID is safe,
      effective, and well tolerated. Technique of ID can be learned easily. Universal
      ID with 1 ml is the ethical solution, which is easy to administer and monitor,
      economical, effective, and imparts early immunity (Five E's).
FAU - Mathew, Thomas
AU  - Mathew T
AD  - Department of Community Medicine, Government Medical College, Thiruvananthapuram 
      & Nodal Officer, IDRV Kerala, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Public Health
JT  - Indian journal of public health
JID - 0400673
RN  - 0 (Rabies Vaccines)
SB  - IM
MH  - Animals
MH  - Humans
MH  - India/epidemiology
MH  - Injections, Intradermal
MH  - Rabies/epidemiology/*prevention & control
MH  - Rabies Vaccines/administration & dosage/*therapeutic use
EDAT- 2012/12/12 06:00
MHDA- 2013/02/13 06:00
CRDT- 2012/12/12 06:00
PHST- 2012/12/12 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
AID - IndianJPublicHealth_2012_56_3_187_104207 [pii]
AID - 10.4103/0019-557X.104207 [doi]
PST - ppublish
SO  - Indian J Public Health. 2012 Jul-Sep;56(3):187-8. doi: 10.4103/0019-557X.104207.


PMID- 23229088
OWN - NLM
STAT- MEDLINE
DCOM- 20130821
LR  - 20211021
IS  - 1932-2267 (Electronic)
IS  - 1932-2259 (Linking)
VI  - 7
IP  - 1
DP  - 2013 Mar
TI  - Pathways toward the future: points to consider for oncofertility oversight.
PG  - 140-5
LID - 10.1007/s11764-012-0255-5 [doi]
AB  - INTRODUCTION: In September 2007, Northwestern University's Feinberg School of
      Medicine received a $21.1 million dollar, 5-year grant from the National
      Institutes of Health to fund the Oncofertility Consortium (OFC). Over the course 
      of the grant, those engaged with the psychological, legal, social, and ethical
      issues arising from oncofertility provided recommendations to the OFC. The
      inclusion of serious, real-time consideration of ethical issues as a funded focus
      of the grant and the work of scholars in law, bioethics, and economics was a key 
      part of the process of research. Now that this grant has ended, this commentary
      points to some of the issues that came forward during the 5 years of this
      project. Because of the emerging status of oncofertility, these issues are ones
      that need continued discussion and clarification, prompting our call for an
      oversight mechanism to provide guidance for how this technology should proceed.
      METHODS: An initial draft of this commentary arose from notes taken during a
      small colloquium held to discuss the oversight of oncofertility following the
      conclusion of the grant. This colloquium occurred in the fall of 2011. Using
      these notes as a starting point, the draft was then sent to other researchers who
      had been involved with the OFC in considering the psychological, legal, social,
      and ethical issues related to fertility preservation for cancer patients during
      the course of the grant. Finally, this commentary was further framed by the
      authors' review of existing published and gray literature regarding issues
      concerning fertility preservation for cancer patients. RESULTS: We provide
      several points to consider and then offer two suggestions for an oversight
      mechanism for research as it continues. DISCUSSION/CONCLUSIONS: We assert the
      need not just for guidelines for the clinical practice of oncofertility, but also
      for oversight of the scope of this emerging technology because of its profound
      implications. We recognize that many long to a have a child and form a family and
      that, for some, cancer interrupts this path. With the conclusion of this grant,
      we call for the creation of a permanent oversight mechanism to thoughtfully and
      earnestly consider how to guide oncofertility to allow this emerging technology
      to be carefully considered as it develops. IMPLICATIONS FOR CANCER SURVIVORS: The
      circumstances in which fertility preservation should be discussed and the
      patients for whom fertility preservation would be most suitable are important
      guideline issues for people who survive cancer and for their treatment team.
      Oversight of the field of oncofertility would strengthen the rights of cancer
      patients and help protect them from abuses as well as alert health care
      professionals to their correlative duties to these vulnerable patients and
      families.
FAU - Rodriguez, Sarah B
AU  - Rodriguez SB
AD  - Medical Humanities + Bioethics Program, Feinberg School of Medicine, Northwestern
      University, Chicago, IL, USA. srodriguez@northwestern.edu
FAU - Campo-Engelstein, Lisa
AU  - Campo-Engelstein L
FAU - Clayman, Marla L
AU  - Clayman ML
FAU - Knapp, Caprice
AU  - Knapp C
FAU - Quinn, Gwendolyn
AU  - Quinn G
FAU - Zoloth, Laurie
AU  - Zoloth L
FAU - Emanuel, Linda
AU  - Emanuel L
LA  - eng
GR  - RL1 HD058296/HD/NICHD NIH HHS/United States
GR  - RL1HD058296/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20121211
PL  - United States
TA  - J Cancer Surviv
JT  - Journal of cancer survivorship : research and practice
JID - 101307557
SB  - IM
MH  - Confidentiality
MH  - *Fertility Preservation
MH  - *Health Services Needs and Demand
MH  - Humans
MH  - Neoplasms/psychology/*therapy
MH  - Patient Acceptance of Health Care
MH  - Privacy
MH  - Survivors/*psychology
PMC - PMC3568233
MID - NIHMS428305
EDAT- 2012/12/12 06:00
MHDA- 2013/08/22 06:00
CRDT- 2012/12/12 06:00
PHST- 2012/09/21 00:00 [received]
PHST- 2012/11/09 00:00 [accepted]
PHST- 2012/12/12 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/08/22 06:00 [medline]
AID - 10.1007/s11764-012-0255-5 [doi]
PST - ppublish
SO  - J Cancer Surviv. 2013 Mar;7(1):140-5. doi: 10.1007/s11764-012-0255-5. Epub 2012
      Dec 11.


PMID- 23228671
OWN - NLM
STAT- MEDLINE
DCOM- 20161011
LR  - 20161230
IS  - 2340-3284 (Electronic)
IS  - 0034-9356 (Linking)
VI  - 61
IP  - 1
DP  - 2014 Jan
TI  - [Anaestheia for valve replacement in the second trimester of pregnancy].
PG  - 35-8
LID - 10.1016/j.redar.2012.10.010 [doi]
LID - S0034-9356(12)00421-5 [pii]
AB  - Cardiac surgery in the pregnant woman gives rise to several anesthetic
      challenges, as the mother, but mainly the fetus, have a risk of high morbidity
      and mortality. In this context, the cardiopulmonary bypass is the most complex
      period, owing to the risks of fetal hypoxia it entails. Due to the absence, for
      ethical reasons, of prospective trials that provide generally accepted guidelines
      in intraoperative management, it means that physicians have to work based on case
      reports in the literature. These procedures also require team coordination to be 
      successful. The case is presented of a 19 weeks pregnant woman, who required a
      mitral valve replacement, which was achieved with success, and enabled her to
      complete her pregnancy without complications. Details are provided on the
      published references on which our management was based.
CI  - Copyright (c) 2012 Sociedad Espanola de Anestesiologia, Reanimacion y Terapeutica
      del Dolor. Published by Elsevier Espana. All rights reserved.
FAU - Rivero, C
AU  - Rivero C
AD  - Servicio de Anestesiologia, Hospital de Clinicas, Facultad de Medicina,
      Universidad de la Republica, Montevideo, Uruguay. Electronic address:
      claudio.crivargas21@gmail.com.
FAU - Cerizola, M
AU  - Cerizola M
AD  - Servicio de Anestesiologia, Hospital de Clinicas, Facultad de Medicina,
      Universidad de la Republica, Montevideo, Uruguay.
FAU - Kohn, E
AU  - Kohn E
AD  - Servicio de Anestesiologia, Hospital de Clinicas, Facultad de Medicina,
      Universidad de la Republica, Montevideo, Uruguay.
FAU - Riva, J
AU  - Riva J
AD  - Servicio de Anestesiologia, Hospital de Clinicas, Facultad de Medicina,
      Universidad de la Republica, Montevideo, Uruguay.
LA  - spa
PT  - Case Reports
PT  - Journal Article
TT  - Anestesia para sustitucion valvular en el segundo trimestre del embarazo.
DEP - 20121208
PL  - Spain
TA  - Rev Esp Anestesiol Reanim
JT  - Revista espanola de anestesiologia y reanimacion
JID - 0134516
RN  - J2R869A8YF (Succinylcholine)
RN  - UF599785JZ (Fentanyl)
RN  - Z22628B598 (Etomidate)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Anesthesia, General/*methods
MH  - Cardiotocography
MH  - Chorea Gravidarum/etiology
MH  - Dyspnea/etiology
MH  - Emergencies
MH  - Etomidate
MH  - Female
MH  - Fentanyl
MH  - Heart Valve Prosthesis Implantation/*methods
MH  - Humans
MH  - Infant, Newborn
MH  - Mitral Valve Stenosis/complications/diagnosis/*surgery
MH  - Pregnancy
MH  - Pregnancy Complications/*surgery
MH  - Pregnancy Outcome
MH  - *Pregnancy Trimester, Second
MH  - Pulmonary Edema/etiology
MH  - Rheumatic Heart Disease/complications/diagnosis/*surgery
MH  - Succinylcholine
OTO - NOTNLM
OT  - Bypass cardiopulmonar
OT  - Cardiac surgery
OT  - Cardiopulmonary bypass
OT  - Cirugia cardiaca
OT  - Gestacion
OT  - Pregnancy
OT  - Sustitucion valvular cardiaca
OT  - Valve replacement
EDAT- 2012/12/12 06:00
MHDA- 2016/10/12 06:00
CRDT- 2012/12/12 06:00
PHST- 2012/06/22 00:00 [received]
PHST- 2012/10/05 00:00 [revised]
PHST- 2012/10/10 00:00 [accepted]
PHST- 2012/12/12 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2016/10/12 06:00 [medline]
AID - S0034-9356(12)00421-5 [pii]
AID - 10.1016/j.redar.2012.10.010 [doi]
PST - ppublish
SO  - Rev Esp Anestesiol Reanim. 2014 Jan;61(1):35-8. doi: 10.1016/j.redar.2012.10.010.
      Epub 2012 Dec 8.


PMID- 23228657
OWN - NLM
STAT- MEDLINE
DCOM- 20140131
LR  - 20130114
IS  - 1532-2653 (Electronic)
IS  - 0967-5868 (Linking)
VI  - 20
IP  - 2
DP  - 2013 Feb
TI  - Efficacy and ethics of artificial nutrition in patients with neurologic
      impairments in home care.
PG  - 220-3
LID - 10.1016/j.jocn.2012.01.054 [doi]
LID - S0967-5868(12)00342-6 [pii]
AB  - Outcomes, particularly survival, for home-care patients with neurologic
      impairments who receive artificial nutrition, such as home parenteral nutrition
      (HPN) or percutaneous endoscopic gastrostomy (PEG) feeding, remain unclear. The
      efficacy of tube feeding for life prolongation in elderly patients remains
      controversial. The aim of this study was to assess the survival of elderly
      patients with neurologic impairments after the start of HPN or PEG. We
      retrospectively evaluated 80 patients with neurologic impairments who had
      received home care before they died. They were divided into three groups
      according to feeding method: oral-intake group (n = 23), HPN group (n = 21) and
      PEG group (n = 36). The factors considered were: age; survival period after
      commencement of home care; swallowing function; serum albumin concentration;
      level of activities of daily living (ADL); and behavioral, cognitive and
      communication functions. Survival periods of the patients in the PEG (736 +/- 765
      days) and HPN (725 +/- 616 days) groups were twice that of the self-feeding
      oral-intake group (399 +/- 257 days) despite lower serum albumin concentration
      (for PEG patients), reduced swallowing function and cognitive function, and
      poorer levels of ADL at the start of home care. Almost all patients were
      incapable of deciding whether they should receive artificial nutrition due to
      dementia or poor comprehension. Physicians should provide clinical evidence to
      families before commencing PEG feeding or HPN and support their decisions to
      maintain the dignity of the patient.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Shintani, Shuzo
AU  - Shintani S
AD  - Department of Neurology, JA Toride Medical Center, 2-1-1 Hongoh, Toride City,
      Ibaraki 302-0022, Japan. dw4s-sntn@asahi-net.or.jp
LA  - eng
PT  - Journal Article
DEP - 20121208
PL  - Scotland
TA  - J Clin Neurosci
JT  - Journal of clinical neuroscience : official journal of the Neurosurgical Society 
      of Australasia
JID - 9433352
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Enteral Nutrition/*ethics/methods
MH  - Feeding Methods/ethics
MH  - Female
MH  - Follow-Up Studies
MH  - Home Care Services/*ethics
MH  - Humans
MH  - Intubation, Gastrointestinal/ethics/methods
MH  - Male
MH  - Nervous System Diseases/diagnosis/*therapy
MH  - Parenteral Nutrition, Home/*ethics/methods
MH  - Retrospective Studies
MH  - Treatment Outcome
EDAT- 2012/12/12 06:00
MHDA- 2014/02/01 06:00
CRDT- 2012/12/12 06:00
PHST- 2011/11/21 00:00 [received]
PHST- 2012/01/20 00:00 [accepted]
PHST- 2012/12/12 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2014/02/01 06:00 [medline]
AID - S0967-5868(12)00342-6 [pii]
AID - 10.1016/j.jocn.2012.01.054 [doi]
PST - ppublish
SO  - J Clin Neurosci. 2013 Feb;20(2):220-3. doi: 10.1016/j.jocn.2012.01.054. Epub 2012
      Dec 8.


PMID- 23228215
OWN - NLM
STAT- MEDLINE
DCOM- 20130815
LR  - 20181202
IS  - 1525-6049 (Electronic)
IS  - 0886-022X (Linking)
VI  - 35
IP  - 2
DP  - 2013
TI  - The effect of HES (130/0.4) usage as the priming solution on renal function in
      children undergoing cardiac surgery.
PG  - 210-5
LID - 10.3109/0886022X.2012.747139 [doi]
AB  - BACKGROUND: Experience with hydroxyethyl starch (HES) in children is limited.
      This study was conducted to observe the effects of HES or Ringer's lactate (RL)
      usage as the priming solution on renal functions in children undergoing cardiac
      surgery. METHODS: After ethical committee approval and parent informed consent,
      24 patients were included in this prospective, randomized study. During
      cardiopulmonary bypass (CPB), Group I received RL and Group II received HES
      (130/0.4) as priming solution. Serum creatinine, blood urea nitrogen (BUN),
      beta2-microglobulin, cystatin C, and urinary albumin and creatinine, serum, and
      urine electrolytes were analyzed after the induction (T1), before CPB (T2),
      during CPB (T3), after CPB (T4), at the end of the operation (T5), on 24th hour
      (T6), and on 48th hour postoperatively (T7). Fractional sodium excretion (FENa), 
      urinary albumin/creatinine ratio, and creatinine clearance were calculated.
      Drainage, urine output, inotropes, diuretics, and blood requirements were
      recorded. RESULTS: In both the groups, beta2-microglobulin was decreased during
      CPB and cystatin C was decreased at T3,T4, and T5 periods (p < 0.05) and the
      levels remained within the normal range. Creatinine clearance did not differ in
      the HES group, but increased in the RL group (p < 0.05). Urine albumin/creatinine
      ratio was increased (p < 0.05) after CPB in the HES group, and it increased at
      T3, T4, and T5 in the RL group (p < 0.05). There were no differences in cystatin 
      C, beta2-microglobulin, FENa, urine albumin/creatinine ratio, creatinine
      clearance, total fluid amount, urine output, drainage, and inotropic and diuretic
      requirements between the groups. CONCLUSION: We conclude that usage of HES
      (130/0.4) did not have negative effects on renal function, and it can be used as 
      a priming solution in pediatric patients undergoing cardiac surgery.
FAU - Akkucuk, Fulya G
AU  - Akkucuk FG
AD  - Department of Anesthesiology and Reanimation, Faculty of Medicine, Hacettepe
      University, Ankara, Turkey.
FAU - Kanbak, Meral
AU  - Kanbak M
FAU - Ayhan, Banu
AU  - Ayhan B
FAU - Celebioglu, Bilge
AU  - Celebioglu B
FAU - Aypar, Ulku
AU  - Aypar U
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20121211
PL  - England
TA  - Ren Fail
JT  - Renal failure
JID - 8701128
RN  - 0 (Cystatin C)
RN  - 0 (Hydroxyethyl Starch Derivatives)
RN  - 0 (Isotonic Solutions)
RN  - 0 (Ringer's Lactate)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Acute Kidney Injury/etiology/*prevention & control
MH  - Adolescent
MH  - Blood Chemical Analysis
MH  - Cardiac Surgical Procedures/adverse effects/*methods
MH  - Cardiopulmonary Bypass/*adverse effects/methods
MH  - Chi-Square Distribution
MH  - Child
MH  - Child, Preschool
MH  - Creatinine/urine
MH  - Cystatin C/blood
MH  - Female
MH  - Heart Defects, Congenital/complications/diagnosis/surgery
MH  - Humans
MH  - Hydroxyethyl Starch Derivatives/*pharmacology
MH  - Intraoperative Care/methods
MH  - Isotonic Solutions/pharmacology
MH  - Kidney Function Tests
MH  - Male
MH  - Prospective Studies
MH  - Reference Values
MH  - Ringer's Lactate
MH  - Statistics, Nonparametric
MH  - Urinalysis
EDAT- 2012/12/12 06:00
MHDA- 2013/08/16 06:00
CRDT- 2012/12/12 06:00
PHST- 2012/12/12 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/08/16 06:00 [medline]
AID - 10.3109/0886022X.2012.747139 [doi]
PST - ppublish
SO  - Ren Fail. 2013;35(2):210-5. doi: 10.3109/0886022X.2012.747139. Epub 2012 Dec 11.


PMID- 23228107
OWN - NLM
STAT- MEDLINE
DCOM- 20130911
LR  - 20130219
IS  - 1466-187X (Electronic)
IS  - 0142-159X (Linking)
VI  - 35
IP  - 2
DP  - 2013
TI  - Writing for academia: getting your research into print: AMEE Guide No. 74.
PG  - e926-34
LID - 10.3109/0142159X.2012.742494 [doi]
AB  - The authors identify and describe strategies for success in writing for
      publication, including how to choose an educational research topic, define the
      question and choose the correct design, know the anatomy of a research paper,
      write each of the sections, optimize the writing before publication, choose a
      journal, and respond to editors and reviewers. The research question should be
      focused, modest, and achievable given the constraints of the setting,
      significant, and appropriately imbedded in the available literature. The choice
      of methods is determined by the nature of the educational research question and
      should conform to ethical standards. Specific strategies for writing include
      starting where it is easiest to do so, spontaneously and uncritically writing the
      first paragraphs through, minimizing external impediments to the work, and
      knowing how each section of a manuscript is routinely structured. All papers
      require a number of revisions with careful attention to accuracy and detail as
      well as to specific requirements of the target journal before submission. Authors
      should respond positively, not defensively, and in detail to all of the editor's 
      and reviewers' suggestions for revision. Writing for success is therefore a
      disciplined and systematic process following prescribed steps, which, although
      hard work, is rewarding.
FAU - Coverdale, John H
AU  - Coverdale JH
AD  - Menninger Department of Psychiatry, Baylor College of Medicine, Houston, TX, USA.
FAU - Roberts, Laura Weiss
AU  - Roberts LW
FAU - Balon, Richard
AU  - Balon R
FAU - Beresin, Eugene V
AU  - Beresin EV
LA  - eng
PT  - Journal Article
DEP - 20121211
PL  - England
TA  - Med Teach
JT  - Medical teacher
JID - 7909593
SB  - IM
MH  - *Education, Medical
MH  - Humans
MH  - *Periodicals as Topic
MH  - Research/*organization & administration
MH  - Research Design
MH  - *Universities
MH  - *Writing
EDAT- 2012/12/12 06:00
MHDA- 2013/09/12 06:00
CRDT- 2012/12/12 06:00
PHST- 2012/12/12 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/09/12 06:00 [medline]
AID - 10.3109/0142159X.2012.742494 [doi]
PST - ppublish
SO  - Med Teach. 2013;35(2):e926-34. doi: 10.3109/0142159X.2012.742494. Epub 2012 Dec
      11.


PMID- 23228106
OWN - NLM
STAT- MEDLINE
DCOM- 20130919
LR  - 20220316
IS  - 1466-187X (Electronic)
IS  - 0142-159X (Linking)
VI  - 35
IP  - 3
DP  - 2013
TI  - Medical dramas on television: a brief guide for educators.
PG  - 237-42
LID - 10.3109/0142159X.2012.737960 [doi]
AB  - The popularity of medical television dramas is well-established and medical
      educators are beginning to recognize the power of medical media as a potential
      tool for education. The purpose of this study was to view a number of medical
      dramas and consider their potential use in medical education. A total of 177
      episodes from eight popular television medical dramas produced between 1990 and
      2009 were systematically viewed and analyzed and a brief guide was developed for 
      each drama. The dramas analyzed contained a wealth of material applicable to
      medical education. In our experience, each drama may be best suited to a
      particular educational use: for example, clips from "ER" and "Scrubs" offer more 
      examples of teaching and learning than "House" and "Grey's Anatomy", which are
      perhaps better suited for topics on ethics or team work. We hope that this brief 
      guide will encourage others to consider integrating this material into their
      teaching, and to explore how television drama may be used most effectively in
      medical education.
FAU - Hirt, C
AU  - Hirt C
AD  - Faculty of Medicine, University of Alberta, Canada. chirt@ualberta.ca
FAU - Wong, K
AU  - Wong K
FAU - Erichsen, S
AU  - Erichsen S
FAU - White, J S
AU  - White JS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121211
PL  - England
TA  - Med Teach
JT  - Medical teacher
JID - 7909593
SB  - IM
MH  - *Drama
MH  - *Faculty, Medical
MH  - *Medicine in the Arts
MH  - *Teaching
MH  - *Television
EDAT- 2012/12/12 06:00
MHDA- 2013/09/21 06:00
CRDT- 2012/12/12 06:00
PHST- 2012/12/12 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/09/21 06:00 [medline]
AID - 10.3109/0142159X.2012.737960 [doi]
PST - ppublish
SO  - Med Teach. 2013;35(3):237-42. doi: 10.3109/0142159X.2012.737960. Epub 2012 Dec
      11.


PMID- 23228069
OWN - NLM
STAT- MEDLINE
DCOM- 20130528
LR  - 20211021
IS  - 1472-6882 (Electronic)
IS  - 1472-6882 (Linking)
VI  - 12
DP  - 2012 Dec 10
TI  - Prakriti (Ayurvedic concept of constitution) and variations in platelet
      aggregation.
PG  - 248
LID - 10.1186/1472-6882-12-248 [doi]
AB  - BACKGROUND: Ayurveda, the Indian traditional system of medicine describes a
      unique concept "prakriti", genetically determined, categorising the population
      into several subgroups based on phenotypic characters like appearance,
      temperament and habits. The concept is claimed to be useful in predicting an
      individual's susceptibility to a particular disease, prognosis of that illness
      and selection of therapy. The present study was carried out to study if the
      platelet aggregatory response and its inhibition by aspirin varied in the
      different prakriti subtypes. METHODS: After obtaining Institutional Ethics
      Committee permission, normal healthy individuals of either sex between the age
      group 18 to 30 years were recruited in the study. Their prakriti evaluation was
      done using a standardized validated questionnaire (TNMC Prakriti 2004). Their
      Platelet Rich Plasma was incubated with either aspirin [2.5 micro-mole (muM) and 
      5 muM] or distilled water as control for three minutes after which the
      aggregatory response to 5 muM Adenosine Diphosphate (ADP) was measured over a
      period of 7 minutes. RESULTS: We observed that in the study population of normal 
      healthy participants (n= 137), ADP-induced maximal platelet aggregation (MPA) was
      highest among the Vata-pitta prakriti individuals [Median (range), 83.33%
      (52.33-96)] as compared to the other prakriti types and these individuals
      responded better to lower dose of aspirin compared to other prakriti types.
      CONCLUSIONS: Our results suggest that identifying the prakriti may help in
      individualising therapy or predicting proneness to a disease.
FAU - Bhalerao, Supriya
AU  - Bhalerao S
AD  - Dept. of Clinical Pharmacology, TN Medical College & BYL Nair Ch. Hospital,
      Mumbai Central, Mumbai 400 008, India.
FAU - Deshpande, Tejashree
AU  - Deshpande T
FAU - Thatte, Urmila
AU  - Thatte U
LA  - eng
PT  - Journal Article
DEP - 20121210
PL  - England
TA  - BMC Complement Altern Med
JT  - BMC complementary and alternative medicine
JID - 101088661
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - Adult
MH  - Aspirin/*pharmacology
MH  - Female
MH  - Humans
MH  - India
MH  - Life Style
MH  - Male
MH  - *Medicine, Ayurvedic
MH  - Platelet Aggregation/*drug effects
MH  - Surveys and Questionnaires
MH  - Young Adult
PMC - PMC3562518
EDAT- 2012/12/12 06:00
MHDA- 2013/05/29 06:00
CRDT- 2012/12/12 06:00
PHST- 2012/07/23 00:00 [received]
PHST- 2012/12/07 00:00 [accepted]
PHST- 2012/12/12 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/05/29 06:00 [medline]
AID - 1472-6882-12-248 [pii]
AID - 10.1186/1472-6882-12-248 [doi]
PST - epublish
SO  - BMC Complement Altern Med. 2012 Dec 10;12:248. doi: 10.1186/1472-6882-12-248.


PMID- 23228039
OWN - NLM
STAT- MEDLINE
DCOM- 20150406
LR  - 20140304
IS  - 1365-2702 (Electronic)
IS  - 0962-1067 (Linking)
VI  - 23
IP  - 5-6
DP  - 2014 Mar
TI  - Health status of critically ill trauma patients.
PG  - 704-15
LID - 10.1111/jocn.12026 [doi]
AB  - AIMS AND OBJECTIVES: To describe the recovery of trauma intensive care patients
      up to six months posthospital discharge. BACKGROUND: Injury is a leading cause of
      preventable mortality and morbidity worldwide, with approximately 10% of
      hospitalised trauma patients being admitted to intensive care. Intensive care
      patients experience significant ongoing physical and psychological burden after
      discharge; however, the patterns of recovery and the subgroups of intensive care 
      patients who experience the greatest burden are not described. DESIGN: This
      prospective cohort study was conducted in one tertiary referral hospital in
      south-east Queensland, Australia. METHODS: Following ethics approval, injured
      patients who required admission to intensive care provided consent. Participants 
      completed questionnaires prior to hospital discharge (n = 123) and one (n = 93)
      and six months (n = 88) later. Data included demographic and socioeconomic
      details, pre-injury health, injury characteristics, acute care factors, postacute
      factors [self-efficacy, illness perception, perceived social support and
      psychological status as measured by the Kessler Psychological Distress Scale
      (K10) and the PTSD Civilian Checklist] and health status (SF-36). RESULTS: All
      participants required ongoing support from healthcare providers in the six months
      after discharge from hospital, and approximately half required support services
      such as accommodation and home modifications. Approximately 20% of participants
      reported post-traumatic stress symptoms, while approximately half the
      participants reported psychological distress. Average quality of life scores were
      significantly below the Australian norms both one and six months postdischarge.
      CONCLUSIONS: Trauma intensive care patients rely on ongoing healthcare
      professional and social support services. Compromised health-related quality of
      life and psychological health persists at six months. RELEVANCE TO CLINICAL
      PRACTICE: Effective discharge planning and communication across the care
      continuum is essential to facilitate access to healthcare providers and other
      support services in the community setting.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Aitken, Leanne M
AU  - Aitken LM
AD  - Research Centre for Clinical and Community Practice Innovation (RCCCPI), Griffith
      University & Princess Alexandra Hospital, Brisbane, Qld, Australia.
FAU - Chaboyer, Wendy
AU  - Chaboyer W
FAU - Schuetz, Michael
AU  - Schuetz M
FAU - Joyce, Christopher
AU  - Joyce C
FAU - Macfarlane, Bonnie
AU  - Macfarlane B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121210
PL  - England
TA  - J Clin Nurs
JT  - Journal of clinical nursing
JID - 9207302
MH  - Adult
MH  - *Critical Illness
MH  - Female
MH  - *Health Status
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Self Efficacy
MH  - Stress, Psychological
MH  - Wounds and Injuries/*physiopathology
OTO - NOTNLM
OT  - health status
OT  - intensive care
OT  - self-efficacy
OT  - stress disorders-post-traumatic
OT  - wounds and injuries
EDAT- 2012/12/12 06:00
MHDA- 2015/04/07 06:00
CRDT- 2012/12/12 06:00
PHST- 2012/08/05 00:00 [accepted]
PHST- 2012/12/12 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2015/04/07 06:00 [medline]
AID - 10.1111/jocn.12026 [doi]
PST - ppublish
SO  - J Clin Nurs. 2014 Mar;23(5-6):704-15. doi: 10.1111/jocn.12026. Epub 2012 Dec 10.


PMID- 23228008
OWN - NLM
STAT- MEDLINE
DCOM- 20130716
LR  - 20151119
IS  - 1399-6576 (Electronic)
IS  - 0001-5172 (Linking)
VI  - 57
IP  - 3
DP  - 2013 Mar
TI  - Patient perspectives on informed consent for anaesthesia and surgery: American
      attitudes.
PG  - 342-9
LID - 10.1111/aas.12037 [doi]
AB  - BACKGROUND: Principles of informed consent are ethically, morally, and legally
      grounded in physicians' responsibility to patients. This study examined patient
      expectations regarding the informed consent during the perioperative process,
      specifically risk information exchange, preferred method and timing of delivery, 
      and the roles that patient anxiety and understanding might play. METHODS: Five
      hundred patients seen in our pre-operative clinic were surveyed by written
      questionnaire. Patients were asked about their level of agreement with a number
      of statements pertaining to informed consent and their preferences for discussion
      of types of risks. Anxiety concerns, impact of ability to understand complexities
      of care, preferences for timing, and method of presentation were assessed.
      RESULTS: Four hundred eleven of 500 surveys (82%) were completed. A majority of
      respondents (92% and 80%, respectively) believed the risk of common but less
      consequential complications and rare yet severe complications should be
      discussed. Only 21% agreed that anxiety generated by discussion of risks
      outweighed benefit and only 6% agreed that discussion of risks should be
      restricted based on patient inability to appreciate complexities of care.
      Discussion was preferred on the day of surgery, 1 week before, and 1 month before
      in 46%, 35%, and 16% of respondents, respectively, and independent of level of
      anxiety generated by such discussion (P = 0.87). Respondents preferred discussion
      with their anaesthesia provider alone (44%) or in combination with written
      information (52%) as compared with written information only (4%) (P < 0.01).
      CONCLUSIONS: Greater awareness of patient preferences and expectations may result
      in better information exchange between anaesthesia providers and their patients.
CI  - (c) 2012 The Acta Anaesthesiologica Scandinavica Foundation.
FAU - Burkle, C M
AU  - Burkle CM
AD  - Department of Anesthesiology, Mayo Clinic, 200 First Street SW, Rochester, MN
      55905, USA. burkle.christopher@mayo.edu
FAU - Pasternak, J J
AU  - Pasternak JJ
FAU - Armstrong, M H
AU  - Armstrong MH
FAU - Keegan, M T
AU  - Keegan MT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121211
PL  - England
TA  - Acta Anaesthesiol Scand
JT  - Acta anaesthesiologica Scandinavica
JID - 0370270
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Anesthesia/adverse effects
MH  - Anxiety/psychology
MH  - Attitude
MH  - Data Collection
MH  - Fear/psychology
MH  - Female
MH  - Humans
MH  - Informed Consent/psychology/*statistics & numerical data
MH  - Male
MH  - Middle Aged
MH  - Patients
MH  - Preoperative Period
MH  - Risk
MH  - *Surgical Procedures, Operative/adverse effects
MH  - Surveys and Questionnaires
MH  - United States
MH  - Young Adult
EDAT- 2012/12/12 06:00
MHDA- 2013/07/17 06:00
CRDT- 2012/12/12 06:00
PHST- 2012/11/14 00:00 [accepted]
PHST- 2012/12/12 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/07/17 06:00 [medline]
AID - 10.1111/aas.12037 [doi]
PST - ppublish
SO  - Acta Anaesthesiol Scand. 2013 Mar;57(3):342-9. doi: 10.1111/aas.12037. Epub 2012 
      Dec 11.


PMID- 23227880
OWN - NLM
STAT- MEDLINE
DCOM- 20130709
LR  - 20220317
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 13
DP  - 2012 Dec 10
TI  - Removing barriers to participation in clinical trials, a conceptual framework and
      retrospective chart review study.
PG  - 237
LID - 10.1186/1745-6215-13-237 [doi]
AB  - BACKGROUND: Enrollment in interventional therapeutic clinical trials is a small
      fraction of all patients who might participate given reasonable access. METHODS: 
      A hierarchical approach is utilized in measuring staged participation from trial 
      availability to patient enrollment. Our framework suggests that concern for
      justice comes in the design and eligibility criteria for clinical trials;
      attention to beneficence is given in the eligibility and physician triage stages.
      The remaining four stages rely on respect for persons. An example is given where 
      reasons for nonparticipation or barriers to participation in prostate cancer
      clinical trials are examined within the framework. In addition, medical oncology 
      patients with an initial six month consultation are tracked from one stage to the
      next by race using the framework to assess participation comparability. RESULTS: 
      We illustrated seven transitions from being a patient to enrollment in a clinical
      trial in a small study of prostate cancer cases who consulted SKCCC Medical
      Oncology Department in early 2010. Pilot data suggest transition probabilities as
      follows: 65% availability, 84% eligibility, 92% patient triage, 89% trials
      discussed, 45% patient interested, 63% patient consented, and 92% patient
      enrolled. The average transition probability was 77.7%. The average transition
      probability, patient-trial-fit was 50%; opportunity was 51%, and acceptance was
      66.7%. Trial availability, patient interest and patient consented were three
      transitions that were below the average; none were statistically significant.
      CONCLUSIONS: The framework may serve to streamline comprehensive reporting of
      clinical trial participation to the benefit of patients and the ethical conduct
      of clinical trials.
FAU - Kanarek, Norma F
AU  - Kanarek NF
AD  - Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of
      Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA.
      nkanarek@jhsph.edu
FAU - Kanarek, Marty S
AU  - Kanarek MS
FAU - Olatoye, Dare
AU  - Olatoye D
FAU - Carducci, Michael A
AU  - Carducci MA
LA  - eng
PT  - Journal Article
DEP - 20121210
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
SB  - IM
MH  - Attitude of Health Personnel
MH  - Beneficence
MH  - Chi-Square Distribution
MH  - Clinical Trials as Topic/ethics/*methods
MH  - Eligibility Determination
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Informed Consent
MH  - Male
MH  - Patient Acceptance of Health Care
MH  - *Patient Selection/ethics
MH  - Patients/psychology
MH  - Prognosis
MH  - Prostatic Neoplasms/diagnosis/pathology/psychology/*therapy
MH  - Retrospective Studies
MH  - Social Justice
MH  - Value of Life
PMC - PMC3551829
EDAT- 2012/12/12 06:00
MHDA- 2013/07/10 06:00
CRDT- 2012/12/12 06:00
PHST- 2012/09/18 00:00 [received]
PHST- 2012/11/19 00:00 [accepted]
PHST- 2012/12/12 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/07/10 06:00 [medline]
AID - 1745-6215-13-237 [pii]
AID - 10.1186/1745-6215-13-237 [doi]
PST - epublish
SO  - Trials. 2012 Dec 10;13:237. doi: 10.1186/1745-6215-13-237.


PMID- 23227826
OWN - NLM
STAT- MEDLINE
DCOM- 20130603
LR  - 20130404
IS  - 1749-6632 (Electronic)
IS  - 0077-8923 (Linking)
VI  - 1282
DP  - 2013 Apr
TI  - Deep brain stimulation of the nucleus accumbens for the treatment of addiction.
PG  - 119-28
LID - 10.1111/j.1749-6632.2012.06834.x [doi]
AB  - Despite novel medications and other therapeutic strategies, addiction to
      psychotropic substances remains one of the most serious public health problems
      worldwide. In this review, beginning with an introduction of deep brain
      stimulation (DBS), we highlight the importance of the nucleus accumbens (NAc) in 
      the context of the reward circuitry and addictive behavior. We will provide a
      short historic overview of other neurosurgical approaches to treat addiction and 
      describe the experimental and preclinical data on DBS in addiction. Finally, we
      call attention to key ethical issues related to using DBS to treat addiction that
      are important for future research and the design of clinical trials.
CI  - (c) 2012 New York Academy of Sciences.
FAU - Muller, Ulf J
AU  - Muller UJ
AD  - Department of Psychiatry, University of Magdeburg, Magdeburg, Germany.
      ulfmueller@gmail.com
FAU - Voges, Jurgen
AU  - Voges J
FAU - Steiner, Johann
AU  - Steiner J
FAU - Galazky, Imke
AU  - Galazky I
FAU - Heinze, Hans-Jochen
AU  - Heinze HJ
FAU - Moller, Michaela
AU  - Moller M
FAU - Pisapia, Jared
AU  - Pisapia J
FAU - Halpern, Casey
AU  - Halpern C
FAU - Caplan, Arthur
AU  - Caplan A
FAU - Bogerts, Bernhard
AU  - Bogerts B
FAU - Kuhn, Jens
AU  - Kuhn J
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121210
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
SB  - IM
MH  - Animals
MH  - Behavior, Addictive/physiopathology/psychology/*therapy
MH  - Clinical Trials as Topic/ethics/methods/trends
MH  - Deep Brain Stimulation/ethics/*methods/trends
MH  - Humans
MH  - *Nucleus Accumbens/physiopathology
MH  - Treatment Outcome
EDAT- 2012/12/12 06:00
MHDA- 2013/06/05 06:00
CRDT- 2012/12/12 06:00
PHST- 2012/12/12 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/06/05 06:00 [medline]
AID - 10.1111/j.1749-6632.2012.06834.x [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2013 Apr;1282:119-28. doi: 10.1111/j.1749-6632.2012.06834.x.
      Epub 2012 Dec 10.


PMID- 23227701
OWN - NLM
STAT- MEDLINE
DCOM- 20130108
LR  - 20121211
IS  - 0255-2930 (Print)
IS  - 0255-2930 (Linking)
VI  - 32
IP  - 9
DP  - 2012 Sep
TI  - [Acupuncturist ZENG Tian-zhi and his Scientific Acupuncture Therapeutics].
PG  - 848-51
AB  - Mr. ZENG Tian-zhi, one of the first generation students of CHENG Dan-an in
      Chengjiang School of acupuncture and Moxibustion, integrated traditional Chinese 
      medicine and western medicine even if just began to study medicine from his
      mid-life. He has practiced medicine in Guangdong, Guangxi and Hong Kong. He
      founded the Medical School of Science Acupuncture and Moxibustion in Hong Kong to
      teach students, impart professional knowledge, write and publish monographs, and 
      carried forward acupuncture with all his life. The medical learning way, medical 
      ethics, medical achievement and experience of Mr. ZENG, and the Scientific
      Acupuncture Therapeutics will bring a light to the inheritance and development of
      Chengjiang School and can be reference for the modern medical physicians.
FAU - Qu, Shan-Shan
AU  - Qu SS
AD  - TCM School, Southern Medical University, Guangzhou 510515, Guangdong Province,
      China. s2qu@163.com
FAU - Huang, Yong
AU  - Huang Y
LA  - chi
PT  - Biography
PT  - English Abstract
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Zhen Jiu
JT  - Zhongguo zhen jiu = Chinese acupuncture & moxibustion
JID - 8600658
SB  - IM
MH  - Acupuncture/education/history
MH  - Acupuncture Therapy/*history/methods
MH  - China
MH  - History, 20th Century
MH  - Humans
PS  - ZENG TZ
FPS - ZENG, Tian-zhi
EDAT- 2012/12/12 06:00
MHDA- 2013/01/09 06:00
CRDT- 2012/12/12 06:00
PHST- 2012/12/12 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/01/09 06:00 [medline]
PST - ppublish
SO  - Zhongguo Zhen Jiu. 2012 Sep;32(9):848-51.


PMID- 23227700
OWN - NLM
STAT- MEDLINE
DCOM- 20130108
LR  - 20121211
IS  - 0255-2930 (Print)
IS  - 0255-2930 (Linking)
VI  - 32
IP  - 9
DP  - 2012 Sep
TI  - [Biography of the outstanding acupuncturist DU Xiao-shan].
PG  - 845-7
AB  - Professor DU Xiao-shan 's academic thought and clinical experiences was
      introduced in this paper. He has noble medical ethics and is fair to the patients
      without distinction. He has great learning and rich practical experiences, and he
      specializes in all kinds of common diseases as well as many difficult and
      complicated cases. He never stops studying the ancients to make innovation and he
      creates the technique of the quick-puncture and slow-twist and DU's
      heat-reinforce method. He teaches to carry forward acupuncture and moxibustion
      and his achievements have become an important part of acupuncture and moxibustion
      science.
FAU - Ding, Min
AU  - Ding M
AD  - Department of Acupuncture and Moxibustion, Wuxi TCM Hospital, Wuxi 214001,
      Jiangsu Province, China.
FAU - Lu, Rui-Qin
AU  - Lu RQ
FAU - Du, Liang-Dong
AU  - Du LD
FAU - Cao, Li
AU  - Cao L
FAU - Lin, Tian-Yun
AU  - Lin TY
LA  - chi
PT  - Biography
PT  - English Abstract
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Zhen Jiu
JT  - Zhongguo zhen jiu = Chinese acupuncture & moxibustion
JID - 8600658
SB  - IM
MH  - Acupuncture/education/history
MH  - Acupuncture Therapy/*history/methods
MH  - China
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
PS  - DU XS
FPS - DU, Xiao-shan
EDAT- 2012/12/12 06:00
MHDA- 2013/01/09 06:00
CRDT- 2012/12/12 06:00
PHST- 2012/12/12 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/01/09 06:00 [medline]
PST - ppublish
SO  - Zhongguo Zhen Jiu. 2012 Sep;32(9):845-7.


PMID- 23227355
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121212
LR  - 20220409
IS  - 2090-4606 (Electronic)
IS  - 2090-4592 (Linking)
VI  - 2012
DP  - 2012
TI  - In vitro evaluation of sunscreens: an update for the clinicians.
PG  - 352135
LID - 10.5402/2012/352135 [doi]
AB  - Topical sunscreens contain molecules or molecular complexes that can absorb,
      reflect, or scatter UV photons. Evaluation of the efficacy of sunscreen products 
      has been made through the Sun Protection Factor (SPF), a mean of quantitatively
      assessing in vivo the degree of protection offered by sunscreen products against 
      solar radiation. In vivo evaluation of SPF has several drawbacks. First of all,
      this evaluation method is expensive in terms of money and time. Moreover, it
      raises several ethical issues concerning the potential damage to skin volunteers.
      Several in vitro techniques have been developed, but at present there is no
      broadly accepted method. In this paper, we will discuss some of the recent
      advances concerning the in vitro evaluation of sunscreens which would be
      acceptable for replacing in vivo assays.
FAU - Pelizzo, Maria
AU  - Pelizzo M
AD  - Institutes for Photonics and Nanotechnology, National Research Council, Via
      Trasea 7, 35131 Padua, Italy.
FAU - Zattra, Edoardo
AU  - Zattra E
FAU - Nicolosi, Piergiorgio
AU  - Nicolosi P
FAU - Peserico, Andrea
AU  - Peserico A
FAU - Garoli, Denis
AU  - Garoli D
FAU - Alaibac, Mauro
AU  - Alaibac M
LA  - eng
PT  - Journal Article
DEP - 20121127
PL  - Egypt
TA  - ISRN Dermatol
JT  - ISRN dermatology
JID - 101566611
PMC - PMC3514825
EDAT- 2012/12/12 06:00
MHDA- 2012/12/12 06:01
CRDT- 2012/12/11 06:00
PHST- 2012/10/02 00:00 [received]
PHST- 2012/10/30 00:00 [accepted]
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2012/12/12 06:01 [medline]
AID - 10.5402/2012/352135 [doi]
PST - ppublish
SO  - ISRN Dermatol. 2012;2012:352135. doi: 10.5402/2012/352135. Epub 2012 Nov 27.


PMID- 23226998
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1615-6609 (Print)
IS  - 1615-6609 (Linking)
VI  - 9
IP  - 3-4
DP  - 2012 Dec
TI  - Mapping the ethical landscape of carbon capture and storage.
PG  - 249-270
AB  - This article describes a method of scoping for potential ethical contentions
      within a resource constrained research environment where actor participation and 
      bottom-up analysis is precluded. Instead of reverting to a top-down analytical
      structure, a data-led process is devised. This imitates a bottom-up analytic
      structure in the absence of the direct participation of actors, culminating in
      the construction of a map of the ethical landscape; a high-resolution ethical
      matrix of coded interpretations of various actors' ethical framings of the
      technology. Despite its limitations, which are discussed, the map can
      subsequently support the identification of areas where ethical contentions may be
      raised. Here, the method is described with reference to the construction and
      analysis of a map of the ethical landscape of carbon capture and storage
      technology. Taken as a preliminary stage of a larger study, it can support the
      design and initiation of more sophisticated analyses which may integrate stronger
      bottom-up participation and facilitate a reflective, deliberative process amongst
      actors.
FAU - Boucher, Philip
AU  - Boucher P
AD  - Manchester, UK.
FAU - Gough, Clair
AU  - Gough C
LA  - eng
PT  - Journal Article
DEP - 20121205
PL  - Germany
TA  - Poiesis Prax
JT  - Poiesis & praxis : international journal of ethics of science and technology
      assessment
JID - 101083157
PMC - PMC3514696
EDAT- 2012/12/12 06:00
MHDA- 2012/12/12 06:01
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2012/12/12 06:01 [medline]
AID - 10.1007/s10202-012-0117-2 [doi]
AID - 117 [pii]
PST - ppublish
SO  - Poiesis Prax. 2012 Dec;9(3-4):249-270. doi: 10.1007/s10202-012-0117-2. Epub 2012 
      Dec 5.


PMID- 23226994
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1615-6609 (Print)
IS  - 1615-6609 (Linking)
VI  - 9
IP  - 3-4
DP  - 2012 Dec
TI  - Service robots in the mirror of reflective research.
PG  - 181-200
AB  - Service robotics has increasingly become the focus of reflective research on new 
      technologies over the last decade. The current state of technology is
      characterized by prototypical robot systems developed for specific application
      scenarios outside factories. This has enabled context-based Science and
      Technology Studies and technology assessments of service robotic systems. This
      contribution describes the status quo of this reflective research as the starting
      point for interdisciplinary technology assessment (TA), taking account of TA
      studies and, in particular, of publications from the ethical and empirical social
      science perspective. Finally, based on this status quo, evaluation criteria for
      service robots are developed, which are relevant for further reflective research.
FAU - Decker, Michael
AU  - Decker M
AD  - Institute for Technology Assessment and Systems Analysis, Karlsruhe Institute of 
      Technology, Karlstrasse 11, 76133 Karlsruhe, Germany.
LA  - eng
PT  - Journal Article
DEP - 20121113
PL  - Germany
TA  - Poiesis Prax
JT  - Poiesis & praxis : international journal of ethics of science and technology
      assessment
JID - 101083157
PMC - PMC3514711
EDAT- 2012/12/12 06:00
MHDA- 2012/12/12 06:01
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2012/12/12 06:01 [medline]
AID - 10.1007/s10202-012-0111-8 [doi]
AID - 111 [pii]
PST - ppublish
SO  - Poiesis Prax. 2012 Dec;9(3-4):181-200. doi: 10.1007/s10202-012-0111-8. Epub 2012 
      Nov 13.


PMID- 23226855
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121212
LR  - 20211021
IS  - 0019-5545 (Print)
IS  - 0019-5545 (Linking)
VI  - 54
IP  - 3
DP  - 2012 Jul
TI  - Surreptitious practices in the management of persons with serious mental
      illnesses - Perspectives from the schizophrenia research foundation.
PG  - 273-5
LID - 10.4103/0019-5545.102431 [doi]
AB  - The aim of this communication is to briefly describe the surreptitious practices 
      and management of non-adherence, observed at the services offered by the
      Schizophrenia Research Foundation. Screening of records at our services for
      documentations of this practice and the efforts made to deal with non-adherence
      and concealed treatment was done. Surreptitious practices in SCARF's out-patient 
      services and in community outreach programs have been documented. Efforts to
      manage non-adherence include educating families on pharmacotherapy and strategies
      of dealing with non-adherence. At the level the patient, individualised and group
      strategies deal with the issues addressing lack of insight, acceptance of the
      disorder, or dealing with perceived side effects are held. Ethical principles of 
      autonomy, justice, beneficence, and respect are adopted in implementing these
      strategies. There are potential advantages and disadvantages of adopting
      surreptitious treatment strategies in persons with serious mental illnesses.
      There is a need to formulate rigorous guidelines for the management of
      non-adherence.
FAU - Ramachandran, Padmavati
AU  - Ramachandran P
AD  - Schizophrenia Research Foundation, Chennai, Tamil Nadu, India.
FAU - Rangaswamy, Thara
AU  - Rangaswamy T
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Psychiatry
JT  - Indian journal of psychiatry
JID - 0013255
PMC - PMC3512368
OTO - NOTNLM
OT  - Non-adherence
OT  - management
OT  - out patient care
OT  - surreptitious treatment
EDAT- 2012/12/12 06:00
MHDA- 2012/12/12 06:01
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2012/12/12 06:01 [medline]
AID - 10.4103/0019-5545.102431 [doi]
AID - IJPsy-54-273 [pii]
PST - ppublish
SO  - Indian J Psychiatry. 2012 Jul;54(3):273-5. doi: 10.4103/0019-5545.102431.


PMID- 23226854
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121212
LR  - 20211021
IS  - 0019-5545 (Print)
IS  - 0019-5545 (Linking)
VI  - 54
IP  - 3
DP  - 2012 Jul
TI  - On covert medication: The issues involved.
PG  - 271-2
LID - 10.4103/0019-5545.102430 [doi]
AB  - A response to Kala's article on covert medication. This discusses the issue of
      covert medication from points of view of autonomy, insight, legality, liability
      and good practice.
FAU - Sarin, Alok
AU  - Sarin A
AD  - Consultant Psychiatrist, Sitaram Bhartia Institute, New Delhi, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Psychiatry
JT  - Indian journal of psychiatry
JID - 0013255
PMC - PMC3512367
OTO - NOTNLM
OT  - Covert medication
OT  - autonomy
OT  - ethics of practice
OT  - good practice
OT  - insight
EDAT- 2012/12/12 06:00
MHDA- 2012/12/12 06:01
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2012/12/12 06:01 [medline]
AID - 10.4103/0019-5545.102430 [doi]
AID - IJPsy-54-271 [pii]
PST - ppublish
SO  - Indian J Psychiatry. 2012 Jul;54(3):271-2. doi: 10.4103/0019-5545.102430.


PMID- 23226851
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121212
LR  - 20211021
IS  - 0019-5545 (Print)
IS  - 0019-5545 (Linking)
VI  - 54
IP  - 3
DP  - 2012 Jul
TI  - Covert medication; the last option: A case for taking it out of the closet and
      using it selectively.
PG  - 257-65
LID - 10.4103/0019-5545.102427 [doi]
AB  - Covert medication is the practice of hiding medication in food or beverages so
      that it goes undetected. Tablets may be crushed or liquid forms of medication may
      be used for patients who are either not in a position to give consent or refuse
      consent because of lack of insight. It is commonly practised in two distinct
      settings. The first is typically in the western world, in old patients, mostly
      suffering from dementia, admitted in nursing homes. The second is typically in
      resource strapped developing countries, in patients with psychosis, mostly at
      home, when patients refuse medication. The latter, from all accounts available,
      occurs on a large scale, but has not been studied owing to its questionable
      ethical and legal status and it is not discussed in the open by professionals.
      This paper examines the pros and cons of covert medication and argues that it
      should be acknowledged and studied like other therapeutic practices.
FAU - Kala, A K
AU  - Kala AK
AD  - Clinical Director, The Mind Plus, 95 - A, Model Gram, Ludhiana, Punjab, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Psychiatry
JT  - Indian journal of psychiatry
JID - 0013255
PMC - PMC3512364
OTO - NOTNLM
OT  - Covert medication
OT  - ethics
OT  - non-compliance
OT  - surreptitious medication
EDAT- 2012/12/12 06:00
MHDA- 2012/12/12 06:01
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2012/12/12 06:01 [medline]
AID - 10.4103/0019-5545.102427 [doi]
AID - IJPsy-54-257 [pii]
PST - ppublish
SO  - Indian J Psychiatry. 2012 Jul;54(3):257-65. doi: 10.4103/0019-5545.102427.


PMID- 23226848
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121212
LR  - 20220410
IS  - 0019-5545 (Print)
IS  - 0019-5545 (Linking)
VI  - 54
IP  - 3
DP  - 2012 Jul
TI  - Role of antioxidants in generalised anxiety disorder and depression.
PG  - 244-7
LID - 10.4103/0019-5545.102424 [doi]
AB  - BACKGROUND: Anxiety and depression form commonest stress-induced psychiatric
      disorders. To combat the biochemical changes which occur as a result of stress,
      there is antioxidant defence in the biological system. Secondary defence is by
      the nonenzymatic antioxidants like vitamins E (alphatocopherol), C (ascorbic
      acid), and beta-carotene. Therefore, the authors interest was aroused to examine 
      the status of these antioxidants in the biological system of patients suffering
      from stress-induced psychiatric disorders. AIMS: This study was carried out to
      find out whether patients with generalized anxiety disorder (GAD) and depression 
      have any difference in blood serum levels of vitamins A (beta-carotene), C, and E
      in comparison to the normal healthy control group and whether supplementation of 
      adequate doses of vitamins A (beta-carotene), C, and E leads to improvement in
      anxiety and depression and reduction in scores of the patients. MATERIALS AND
      METHODS: Eighty subjects in the age group of 20-60 years, who attended a
      psychiatric clinic of a private hospital and who met inclusion and exclusion
      criteria of the study and consented for psychological evaluation and blood
      screening to find out the serum levels of vitamins A, C, and E, were included in 
      the study. Approval was sought from the institutional ethics committee for
      collecting the blood sample of these subjects before and after vitamins A, C, and
      E supplements given for a period of 6 weeks. STATISTICS ANALYSIS: It was observed
      that patients with GAD and depression had significantly lower levels of vitamins 
      A, C, and E in comparison to healthy controls. After dietary supplementation of
      these vitamins for a period of 6 weeks, a significant reduction in anxiety and
      depression scores of patients was observed (P<0.001). A significant increase in
      the blood levels of antioxidants was observed in patients (P<0.05) except that of
      vitamin E in the group of depressed patients. RESULTS AND CONCLUSION: The
      findings suggest that antioxidant supplement therapy as an adjuvant therapy is
      useful in patients with stress-induced psychiatric disorders and the results have
      been discussed.
FAU - Gautam, Medhavi
AU  - Gautam M
AD  - Santokba Durlabhji Memorial Hospital, Jaipur, Rajasthan, India.
FAU - Agrawal, Mukta
AU  - Agrawal M
FAU - Gautam, Manaswi
AU  - Gautam M
FAU - Sharma, Praveen
AU  - Sharma P
FAU - Gautam, Anita Sharma
AU  - Gautam AS
FAU - Gautam, Shiv
AU  - Gautam S
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Psychiatry
JT  - Indian journal of psychiatry
JID - 0013255
PMC - PMC3512361
OTO - NOTNLM
OT  - Depression
OT  - generalized anxiety disorder
OT  - vitamin A, C, E
EDAT- 2012/12/12 06:00
MHDA- 2012/12/12 06:01
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2012/12/12 06:01 [medline]
AID - 10.4103/0019-5545.102424 [doi]
AID - IJPsy-54-244 [pii]
PST - ppublish
SO  - Indian J Psychiatry. 2012 Jul;54(3):244-7. doi: 10.4103/0019-5545.102424.


PMID- 23226633
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130110
LR  - 20211021
IS  - 2230-8210 (Print)
IS  - 2230-9500 (Linking)
VI  - 16
IP  - 6
DP  - 2012 Nov
TI  - Writing for publication in a medical journal.
PG  - 899-903
LID - 10.4103/2230-8210.102988 [doi]
AB  - The essence of writing for publication in the medical field is distilled into a
      dozen precepts to guide the anxious author. These precepts focus on the attitude 
      of the writer, rather than the mechanics of writing. A medical author must strive
      to be the following: Original, honest, innovative, organized, careful, clear,
      modest, fair-minded, frank, persistent, rigorous, and realistic. These attributes
      are essential because there is a new climate of skepticism among the lay public
      as to the validity of scientific and medical claims. This climate has encouraged 
      journal editors to be demanding of authors and to be especially vigilant about
      plagiarism; originality of all contributions is therefore essential.
FAU - Steen, R Grant
AU  - Steen RG
AD  - Medical Communications Consultants, LLC, 103 Van Doren Place, Chapel Hill, NC,
      USA.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Endocrinol Metab
JT  - Indian journal of endocrinology and metabolism
JID - 101555690
PMC - PMC3510958
OTO - NOTNLM
OT  - Medical writing
OT  - medical ethics
OT  - plagiarism
OT  - publication
EDAT- 2012/12/12 06:00
MHDA- 2012/12/12 06:01
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2012/12/12 06:01 [medline]
AID - 10.4103/2230-8210.102988 [doi]
AID - IJEM-16-899 [pii]
PST - ppublish
SO  - Indian J Endocrinol Metab. 2012 Nov;16(6):899-903. doi: 10.4103/2230-8210.102988.


PMID- 23226627
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 2210-5433 (Print)
IS  - 2210-5433 (Linking)
VI  - 25
IP  - 4
DP  - 2012 Dec
TI  - Natural Selection, Childrearing, and the Ethics of Marriage (and Divorce):
      Building a Case for the Neuroenhancement of Human Relationships.
PG  - 561-587
AB  - We argue that the fragility of contemporary marriages-and the corresponding high 
      rates of divorce-can be explained (in large part) by a three-part mismatch:
      between our relationship values, our evolved psychobiological natures, and our
      modern social, physical, and technological environment. "Love drugs" could help
      address this mismatch by boosting our psychobiologies while keeping our values
      and our environment intact. While individual couples should be free to use
      pharmacological interventions to sustain and improve their romantic connection,
      we suggest that they may have an obligation to do so as well, in certain cases.
      Specifically, we argue that couples with offspring may have a special
      responsibility to enhance their relationships for the sake of their children. We 
      outline an evolutionarily informed research program for identifying promising
      biomedical enhancements of love and commitment.
FAU - Earp, Brian D
AU  - Earp BD
AD  - Oxford Uehiro Centre for Practical Ethics, University of Oxford, Suite 8,
      Littlegate House, St Ebbes Street, Oxford, OX1 1PT UK.
FAU - Sandberg, Anders
AU  - Sandberg A
FAU - Savulescu, Julian
AU  - Savulescu J
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - 086041/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
DEP - 20120705
PL  - Netherlands
TA  - Philos Technol
JT  - Philosophy & technology
JID - 101583724
PMC - PMC3510696
EDAT- 2012/12/12 06:00
MHDA- 2012/12/12 06:01
CRDT- 2012/12/11 06:00
PHST- 2012/03/07 00:00 [received]
PHST- 2012/06/11 00:00 [accepted]
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2012/12/12 06:01 [medline]
AID - 10.1007/s13347-012-0081-8 [doi]
AID - 81 [pii]
PST - ppublish
SO  - Philos Technol. 2012 Dec;25(4):561-587. doi: 10.1007/s13347-012-0081-8. Epub 2012
      Jul 5.


PMID- 23226560
OWN - NLM
STAT- MEDLINE
DCOM- 20130521
LR  - 20220317
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 12
DP  - 2012
TI  - Willingness to participate in HIV vaccine trials among men who have sex with men 
      in Chennai and Mumbai, India: a social ecological approach.
PG  - e51080
LID - 10.1371/journal.pone.0051080 [doi]
AB  - BACKGROUND: Recruitment of low- and middle-income country volunteers from
      most-at-risk populations in HIV vaccine trials is essential to vaccine
      development. In India, men who have sex with men (MSM) are at disproportionately 
      high risk for HIV infection and an important population for trial recruitment.
      Investigations of willingness to participate (WTP) in HIV vaccine trials have
      focused predominantly on individual-level determinants. We explored multi-level
      factors associated with WTP among MSM in India. METHODS: We conducted 12 focus
      groups (n = 68) with low socioeconomic MSM in Chennai and Mumbai, and 14 key
      informant interviews with MSM community leaders and service providers. Focus
      groups/interviews were recorded, transcribed and translated into English. Two
      bilingual investigators conducted thematic analysis using line-by-line coding and
      a constant comparative method, with member-checking by community representatives.
      RESULTS: Factors associated with WTP were evidenced across the social ecology of 
      MSM-social-structural: poverty, HIV-, sexual- and gender non-conformity stigma,
      institutionalized discrimination and government sponsorship of trials;
      community-level: endorsement by MSM community leaders and organizations, and fear
      of within-group discrimination; interpersonal: anticipated family discord,
      partner rejection, having financially-dependent family members and disclosure of 
      same-sex sexuality; and individual-level: HIV vaccine trial knowledge and
      misconceptions, safety concerns, altruism and preventive misconception.
      CONCLUSION: Pervasive familial, community and social-structural factors
      characteristic of the Indian sociocultural context may complicate
      individual-focused approaches to WTP and thereby constrain the effectiveness of
      interventions to support recruitment and retention in HIV vaccine trials.
      Interventions to reduce stigma and discrimination against MSM and people living
      with HIV, capacity-building of MSM community organizations and transparent
      communications tailored to the knowledge and educational level of local
      communities may support meaningful engagement of MSM in HIV vaccine trials.
      Vigilance in providing fair but not excessive compensation and healthcare
      benefits and in mitigating preventive misconception are warranted to support
      ethical conduct of trials among MSM in India.
FAU - Chakrapani, Venkatesan
AU  - Chakrapani V
AD  - Centre for Sexuality and Health Research and Policy, Chennai, India.
FAU - Newman, Peter A
AU  - Newman PA
FAU - Singhal, Neeti
AU  - Singhal N
FAU - Jerajani, Jhalak
AU  - Jerajani J
FAU - Shunmugam, Murali
AU  - Shunmugam M
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121204
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (AIDS Vaccines)
SB  - IM
MH  - AIDS Vaccines/adverse effects/economics/*immunology
MH  - Adult
MH  - Altruism
MH  - *Cities
MH  - Clinical Trials as Topic/economics/*statistics & numerical data
MH  - Demography
MH  - Discrimination, Psychological
MH  - HIV Infections/epidemiology/immunology/prevention & control
MH  - HIV Seropositivity
MH  - Health Knowledge, Attitudes, Practice
MH  - Homosexuality, Male/*statistics & numerical data
MH  - Humans
MH  - India/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Patient Participation/*statistics & numerical data
MH  - *Social Stigma
MH  - Spouses
MH  - Young Adult
PMC - PMC3514227
EDAT- 2012/12/12 06:00
MHDA- 2013/05/23 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/07/04 00:00 [received]
PHST- 2012/10/29 00:00 [accepted]
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/05/23 06:00 [medline]
AID - 10.1371/journal.pone.0051080 [doi]
AID - PONE-D-12-20114 [pii]
PST - ppublish
SO  - PLoS One. 2012;7(12):e51080. doi: 10.1371/journal.pone.0051080. Epub 2012 Dec 4.


PMID- 23226061
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130401
LR  - 20220310
IS  - 1178-7066 (Print)
IS  - 1178-7066 (Linking)
VI  - 5
DP  - 2012
TI  - The role of genetics in pre-eclampsia and potential pharmacogenomic
      interventions.
PG  - 37-51
LID - 10.2147/PGPM.S23141 [doi]
AB  - The pregnancy-specific condition pre-eclampsia not only affects the health of
      mother and baby during pregnancy but also has long-term consequences, increasing 
      the chances of cardiovascular disease in later life. It is accepted that
      pre-eclampsia has a placental origin, but the pathogenic mechanisms leading to
      the systemic endothelial dysfunction characteristic of the disorder remain to be 
      determined. In this review we discuss some key factors regarded as important in
      the development of pre-eclampsia, including immune maladaptation, inadequate
      placentation, oxidative stress, and thrombosis. Genetic factors influence all of 
      these proposed pathophysiological mechanisms. The inherited nature of
      pre-eclampsia has been known for many years, and extensive genetic studies have
      been undertaken in this area. Genetic research offers an attractive strategy for 
      studying the pathogenesis of pre-eclampsia as it avoids the ethical and practical
      difficulties of conducting basic science research during the preclinical phase of
      pre-eclampsia when the underlying pathological changes occur. Although
      pharmacogenomic studies have not yet been conducted in pre-eclampsia, a number of
      studies investigating treatment for essential hypertension are of relevance to
      therapies used in pre-eclampsia. The pharmacogenomics of antiplatelet agents,
      alpha and beta blockers, calcium channel blockers, and magnesium sulfate are
      discussed in relation to the treatment and prevention of pre-eclampsia.
      Pharmacogenomics offers the prospect of individualized patient treatment,
      ensuring swift introduction of optimal treatment whilst minimizing the use of
      inappropriate or ineffective drugs, thereby reducing the risk of harmful effects 
      to both mother and baby.
FAU - Williams, Paula Juliet
AU  - Williams PJ
AD  - Human Genetics Research Group, University of Nottingham, Nottingham, UK.
FAU - Morgan, Linda
AU  - Morgan L
LA  - eng
PT  - Journal Article
DEP - 20120120
PL  - New Zealand
TA  - Pharmgenomics Pers Med
JT  - Pharmacogenomics and personalized medicine
JID - 101514107
PMC - PMC3513227
OTO - NOTNLM
OT  - genetics
OT  - pharmacogenetics
OT  - placenta
OT  - pre-eclampsia
OT  - trophoblast
EDAT- 2012/12/12 06:00
MHDA- 2012/12/12 06:01
CRDT- 2012/12/11 06:00
PHST- 2012/01/19 00:00 [received]
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2012/12/12 06:01 [medline]
AID - 10.2147/PGPM.S23141 [doi]
AID - pgpm-5-037 [pii]
PST - ppublish
SO  - Pharmgenomics Pers Med. 2012;5:37-51. doi: 10.2147/PGPM.S23141. Epub 2012 Jan 20.


PMID- 23226023
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121211
LR  - 20211021
IS  - 1178-2234 (Electronic)
IS  - 1178-2234 (Linking)
VI  - 6
DP  - 2012
TI  - Is the Improved Efficacy of Trastuzumab and Lapatinib Combination Worth the Added
      Toxicity? A Discussion of Current Evidence, Recommendations, and Ethical Issues
      Regarding Dual HER2-Targeted Therapy.
PG  - 191-207
LID - 10.4137/BCBCR.S9301 [doi]
AB  - Following FDA approval of trastuzumab in 1998 and lapatinib in 2007, several
      clinical studies have addressed the question of whether trastuzumab and lapatinib
      combination therapy is better than trastuzumab alone in the metastatic breast
      cancer and neoadjuvant setting. In this review, updated to September 2012, we
      focus on the relevant clinical trials that address this question and, based on
      the available data, reach conclusions regarding a rational and reasonably
      individualized approach to the management of HER2+ breast cancer. With the FDA
      approval of pertuzumab in June 2012 and the likely approval of T-DM1 approaching,
      several ethical issues overshadow the excitement oncologists have for these new
      treatment options. We discuss the potential evolution of highly active anti-HER2 
      therapy (HAAHT) as an optimal treatment paradigm for HER2+ breast cancer.
      Additionally, we review lessons learned from the evolution of HAART for HIV
      treatment.
FAU - Ahn, Eugene R
AU  - Ahn ER
AD  - University of Miami Miller School of Medicine, Sylvester Comprehensive Cancer
      Center, Miami, FL, USA.
FAU - Wang, Emilie
AU  - Wang E
FAU - Gluck, Stefan
AU  - Gluck S
LA  - eng
PT  - Journal Article
DEP - 20121119
PL  - United States
TA  - Breast Cancer (Auckl)
JT  - Breast cancer : basic and clinical research
JID - 101474356
PMC - PMC3512454
OTO - NOTNLM
OT  - HER2
OT  - T-DM1
OT  - breast cancer
OT  - dual
OT  - lapatinib
OT  - pertuzumab
OT  - trastuzumab
EDAT- 2012/12/12 06:00
MHDA- 2012/12/12 06:01
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2012/12/12 06:01 [medline]
AID - 10.4137/BCBCR.S9301 [doi]
AID - bcbcr-6-2012-191 [pii]
PST - ppublish
SO  - Breast Cancer (Auckl). 2012;6:191-207. doi: 10.4137/BCBCR.S9301. Epub 2012 Nov
      19.


PMID- 23225675
OWN - NLM
STAT- MEDLINE
DCOM- 20130211
LR  - 20121211
IS  - 1930-7837 (Electronic)
IS  - 0022-0337 (Linking)
VI  - 76
IP  - 12
DP  - 2012 Dec
TI  - Implementation of portfolio assessment of student competence in two dental school
      populations.
PG  - 1559-71
AB  - The purpose of this article is to describe the process and procedures involved in
      the implementation of portfolio assessment at two dental schools. Portfolios can 
      be defined as a purposeful collection of student work that involves reflection in
      which students identify gaps in their knowledge and abilities and develop
      strategies for correcting those gaps. Framed within the current context of dental
      education and the calls for change in the ways dental students are taught and
      assessed, these two dental schools embarked upon an assessment strategy aimed at 
      engaging students in self-directed learning and self-assessment. Where one school
      chose the implementation of programmatic portfolios based on all program
      competencies, the other school implemented portfolio assessment around specific
      program competencies not typically captured easily with traditional assessment
      measures such as ethics and ethical decision making. In a competency-based dental
      curriculum in which competence has been defined as the ability to accurately
      self-assess, it makes sense that strategies aimed at developing the skill of
      self-assessment should be the goal of every dental education program.
FAU - Gadbury-Amyot, Cynthia C
AU  - Gadbury-Amyot CC
AD  - School of Dentistry, University of Missouri-Kansas City, 650 E. 25 Street, Kansas
      City, MO 64108, USA. amyotc@umkc.edu
FAU - McCracken, Michael S
AU  - McCracken MS
FAU - Woldt, Janet L
AU  - Woldt JL
FAU - Brennan, Robert
AU  - Brennan R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PL  - United States
TA  - J Dent Educ
JT  - Journal of dental education
JID - 8000150
SB  - IM
MH  - *Competency-Based Education
MH  - Computer-Assisted Instruction/methods
MH  - *Documentation
MH  - Education, Dental/methods/*standards
MH  - Educational Measurement/*methods
MH  - Humans
MH  - Mentors
MH  - Problem Solving
MH  - *Professional Competence
MH  - Program Evaluation
MH  - Reproducibility of Results
MH  - Schools, Dental
MH  - Self-Assessment
EDAT- 2012/12/12 06:00
MHDA- 2013/02/12 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/02/12 06:00 [medline]
AID - 76/12/1559 [pii]
PST - ppublish
SO  - J Dent Educ. 2012 Dec;76(12):1559-71.


PMID- 23225592
OWN - NLM
STAT- MEDLINE
DCOM- 20131212
LR  - 20131029
IS  - 1090-3941 (Print)
IS  - 1090-3941 (Linking)
VI  - 22
DP  - 2012 Dec
TI  - Retrospective study on the use of a composite mesh (Physiomesh) in laparoscopic
      ventral hernia repair.
PG  - 141-5
AB  - The ideal mesh suited for intraperitoneal placement should address both
      requirements of tissue separation on the visceral surface and tissue integration 
      on the parietal surface. Meshes with bioresorbable coatings have recently been
      demonstrated to be successful. In this article, the results are shown of a study 
      with a new type of tissue-separating lightweight mesh with a bioresorbable
      coating (Physiomesh; Ethicon, Somerville, NJ) in laparoscopic ventral hernia
      repair. In this single-center retrospective analysis, 88 patients (50 men, 38
      women) undergoing hernia surgery between November 16, 2010 and August 10, 2012 at
      the Imelda Hospital Bonheiden were included. Patients were asked to score their
      pre- and postoperative pain (1 month after surgery) on a visual analogue scale
      (VAS), as well as the chronic postoperative pain (pain at more than 6 months
      after surgery). The time period after which patients were pain free and after
      which they could return to work was also noted. Our results demonstrate that
      Physiomesh is a good alternative to the existing meshes leading to significant
      pain reduction, early return to work, acceptable complications, and low
      recurrence and reintervention rates.
FAU - Tollens, Tim
AU  - Tollens T
AD  - Imelda Hospital, Bonheiden, Belgium.
FAU - Maxime, Elens
AU  - Maxime E
FAU - Anthony, Beunis
AU  - Anthony B
FAU - Aelvoet, Chris
AU  - Aelvoet C
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Surg Technol Int
JT  - Surgical technology international
JID - 9604509
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Belgium/epidemiology
MH  - Comorbidity
MH  - Female
MH  - Hernia, Ventral/*epidemiology/*surgery
MH  - Humans
MH  - Incidence
MH  - Laparoscopy/*statistics & numerical data
MH  - Male
MH  - Middle Aged
MH  - Pain, Postoperative/*epidemiology/*prevention & control
MH  - Prosthesis Design
MH  - Prosthesis Implantation/methods/statistics & numerical data
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Surgical Mesh/*statistics & numerical data
MH  - Treatment Outcome
EDAT- 2012/12/12 06:00
MHDA- 2013/12/18 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
AID - sti22/28 [pii]
PST - ppublish
SO  - Surg Technol Int. 2012 Dec;22:141-5.


PMID- 23225219
OWN - NLM
STAT- MEDLINE
DCOM- 20131122
LR  - 20211021
IS  - 1525-1497 (Electronic)
IS  - 0884-8734 (Linking)
VI  - 28
IP  - 5
DP  - 2013 May
TI  - Ethical concerns related to grateful patient philanthropy: the physician's
      perspective.
PG  - 645-51
LID - 10.1007/s11606-012-2246-7 [doi]
AB  - BACKGROUND: Philanthropic contributions to academic medical centers from grateful
      patients support research, patient care, education, and capital projects. The
      goal of this study was to identify the ethical concerns associated with
      philanthropic gifts from grateful patients. METHODS: A qualitative study design
      was selected. Investigators conducted in-depth semi-structured interviews with 20
      Department of Medicine physicians at Johns Hopkins who were identified by
      Development Office staff as experienced and successful in this realm-those having
      relationships with multiple patients who have made philanthropic contributions.
      Interview transcripts were independently coded by two investigators. Content
      analysis identified several themes related to ethical concerns. RESULTS: Eighteen
      informants (90 %) were Associate Professors or Professors; two (10 %) were
      females. Four thematic domains emerged related to ethical concerns associated
      with philanthropy from grateful patients: (i) impact of gift on the
      doctor-patient relationship; (ii) gift acquisition considered beyond the
      physician's professional role; (iii) justice and fairness; and (iv) vulnerability
      of patients. Despite acknowledging at least one of the aforementioned concerns,
      eleven physician informants (55 %) expressed the view that there were no ethical 
      issues involved with grateful patient philanthropy. CONCLUSIONS: In this paper,
      we report that physicians involved in grateful patient philanthropy are aware of,
      and in some cases troubled by, the ethical concerns related to this activity.
      Further studies could examine how best to prepare faculty for the challenges that
      may accompany these gifts so as to help them maintain expected professional and
      ethical standards when accepting grateful patient philanthropy.
FAU - Wright, Scott M
AU  - Wright SM
AD  - Divisions of General Internal Medicine, Johns Hopkins Bayview Medical Center,
      Johns Hopkins University School of Medicine, Baltimore, MD, USA. swright@jhmi.edu
FAU - Wolfe, Leah
AU  - Wolfe L
FAU - Stewart, Rosalyn
AU  - Stewart R
FAU - Flynn, John A
AU  - Flynn JA
FAU - Paisner, Richard
AU  - Paisner R
FAU - Rum, Steve
AU  - Rum S
FAU - Parson, Gregory
AU  - Parson G
FAU - Carrese, Joseph
AU  - Carrese J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121206
PL  - United States
TA  - J Gen Intern Med
JT  - Journal of general internal medicine
JID - 8605834
SB  - IM
CIN - J Gen Intern Med. 2013 May;28(5):608-9. PMID: 23423454
MH  - Academic Medical Centers/*ethics
MH  - *Attitude of Health Personnel
MH  - Baltimore
MH  - Ethics, Institutional
MH  - Female
MH  - Fund Raising/ethics
MH  - Gift Giving/*ethics
MH  - Humans
MH  - Male
MH  - Physician's Role
MH  - Physician-Patient Relations/*ethics
MH  - Qualitative Research
PMC - PMC3631061
EDAT- 2012/12/12 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/06/11 00:00 [received]
PHST- 2012/10/01 00:00 [accepted]
PHST- 2012/08/31 00:00 [revised]
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1007/s11606-012-2246-7 [doi]
PST - ppublish
SO  - J Gen Intern Med. 2013 May;28(5):645-51. doi: 10.1007/s11606-012-2246-7. Epub
      2012 Dec 6.


PMID- 23224728
OWN - NLM
STAT- MEDLINE
DCOM- 20140122
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 3
DP  - 2013 Sep
TI  - Just sustainability? Sustainability and social justice in professional codes of
      ethics for engineers.
PG  - 875-91
LID - 10.1007/s11948-012-9421-4 [doi]
AB  - Should environmental, social, and economic sustainability be of primary concern
      to engineers? Should social justice be among these concerns? Although the
      deterioration of our natural environment and the increase in social injustices
      are among today's most pressing and important issues, engineering codes of ethics
      and their paramountcy clause, which contains those values most important to
      engineering and to what it means to be an engineer, do not yet put either concept
      on a par with the safety, health, and welfare of the public. This paper addresses
      a recent proposal by Michelfelder and Jones (2011) to include sustainability in
      the paramountcy clause as a way of rectifying the current disregard for social
      justice issues in the engineering codes. That proposal builds on a certain notion
      of sustainability that includes social justice as one of its dimensions and
      claims that social justice is a necessary condition for sustainability, not vice 
      versa. The relationship between these concepts is discussed, and the original
      proposal is rejected. Drawing on insights developed throughout the paper, some
      suggestions are made as to how one should address the different requirements that
      theory and practice demand of the value taxonomy of professional codes of ethics.
FAU - Brauer, Cletus S
AU  - Brauer CS
AD  - Department of Philosophy and Ethics, Eindhoven University of Technology,
      Eindhoven, The Netherlands. c.s.brauer@tue.nl
LA  - eng
PT  - Journal Article
DEP - 20121207
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Codes of Ethics
MH  - *Conservation of Natural Resources
MH  - Engineering/*ethics
MH  - Humans
MH  - *Public Health
MH  - *Safety
MH  - *Social Justice
MH  - *Social Responsibility
EDAT- 2012/12/12 06:00
MHDA- 2014/01/23 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/09/12 00:00 [received]
PHST- 2012/11/25 00:00 [accepted]
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2014/01/23 06:00 [medline]
AID - 10.1007/s11948-012-9421-4 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Sep;19(3):875-91. doi: 10.1007/s11948-012-9421-4. Epub 2012 
      Dec 7.


PMID- 23224703
OWN - NLM
STAT- MEDLINE
DCOM- 20140122
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 3
DP  - 2013 Sep
TI  - The why and how of enabling the integration of social and ethical aspects in
      research and development.
PG  - 703-25
LID - 10.1007/s11948-012-9423-2 [doi]
AB  - New and Emerging Science and Technology (NEST) based innovations, e.g. in the
      field of Life Sciences or Nanotechnology, frequently raise societal and political
      concerns. To address these concerns NEST researchers are expected to deploy
      socially responsible R&D practices. This requires researchers to integrate social
      and ethical aspects (SEAs) in their daily work. Many methods can facilitate such 
      integration. Still, why and how researchers should and could use SEAs remains
      largely unclear. In this paper we aim to relate motivations for NEST researchers 
      to include SEAs in their work, and the requirements to establish such integration
      from their perspectives, to existing approaches that can be used to establish
      integration of SEAs in the daily work of these NEST researchers. Based on our
      analyses, we argue that for the successful integration of SEAs in R&D practice,
      collaborative approaches between researchers and scholars from the social
      sciences and humanities seem the most successful. The only way to explore whether
      that is in fact the case, is by embarking on collaborative research endeavours.
FAU - Flipse, Steven M
AU  - Flipse SM
AD  - Department of Biotechnology, Delft University of Technology, Delft, The
      Netherlands. S.M.Flipse@TUDelft.nl
FAU - van der Sanden, Maarten C A
AU  - van der Sanden MC
FAU - Osseweijer, Patricia
AU  - Osseweijer P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121206
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Cooperative Behavior
MH  - *Humanities
MH  - Humans
MH  - *Interdisciplinary Communication
MH  - Motivation
MH  - Research Design
MH  - Research Personnel
MH  - Science/*ethics
MH  - *Social Responsibility
MH  - *Social Sciences
MH  - Technology/*ethics
EDAT- 2012/12/12 06:00
MHDA- 2014/01/23 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/08/28 00:00 [received]
PHST- 2012/11/27 00:00 [accepted]
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2014/01/23 06:00 [medline]
AID - 10.1007/s11948-012-9423-2 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Sep;19(3):703-25. doi: 10.1007/s11948-012-9423-2. Epub 2012 
      Dec 6.


PMID- 23224702
OWN - NLM
STAT- MEDLINE
DCOM- 20140122
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 3
DP  - 2013 Sep
TI  - Mega-sized concerns from the nano-sized world: the intersection of nano- and
      environmental ethics.
PG  - 1007-16
LID - 10.1007/s11948-012-9422-3 [doi]
AB  - As rapid advances in nanotechnology are made, we must set guidelines to balance
      the interests of both human beneficiaries and the environment by combining
      nanoethics and environmental ethics. In this paper, I reject Leopoldian holism as
      a practical environmental ethic with which to gauge nanotechnologies because, as 
      a nonanthropocentric ethic, it does not value the humans who will actually use
      the ethic. Weak anthropocentrism is suggested as a reasonable alternative to
      ethics without a substantial human interest, as it treats nonhuman interests as
      human interests. I also establish the precautionary principle as a useful
      situational guideline for decision makers. Finally, I examine existing and
      potential applications of nanotechnology, including water purification,
      agriculture, mining, energy, and pollutant removal, from the perspective of weak 
      anthropocentrism using the precautionary principle.
FAU - Attia, Peter
AU  - Attia P
AD  - Department of Chemical Engineering, University of Delaware, Newark, DE 19716,
      USA. pattia@udel.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20121206
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Decision Making/ethics
MH  - *Environment
MH  - *Environmental Health
MH  - Guidelines as Topic
MH  - Humans
MH  - Industry
MH  - Nanotechnology/*ethics
MH  - Risk Assessment
MH  - *Social Responsibility
EDAT- 2012/12/12 06:00
MHDA- 2014/01/23 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/09/24 00:00 [received]
PHST- 2012/11/25 00:00 [accepted]
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2014/01/23 06:00 [medline]
AID - 10.1007/s11948-012-9422-3 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Sep;19(3):1007-16. doi: 10.1007/s11948-012-9422-3. Epub 2012
      Dec 6.


PMID- 23224537
OWN - NLM
STAT- MEDLINE
DCOM- 20121217
LR  - 20121211
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Linking)
VI  - 338
IP  - 6112
DP  - 2012 Dec 7
TI  - Voles, vasopressin, and the ethics of framing.
PG  - 1285
LID - 10.1126/science.338.6112.1285-a [doi]
FAU - McKaughan, Daniel J
AU  - McKaughan DJ
FAU - Elliott, Kevin C
AU  - Elliott KC
LA  - eng
PT  - Letter
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Receptors, Vasopressin)
RN  - 11000-17-2 (Vasopressins)
SB  - IM
MH  - Animal Experimentation/*ethics
MH  - Animals
MH  - Arvicolinae/*physiology/*psychology
MH  - *Ethics, Research
MH  - Mass Media/*ethics
MH  - Receptors, Vasopressin/physiology
MH  - Vasopressins/*physiology
EDAT- 2012/12/12 06:00
MHDA- 2012/12/18 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2012/12/18 06:00 [medline]
AID - 338/6112/1285-a [pii]
AID - 10.1126/science.338.6112.1285-a [doi]
PST - ppublish
SO  - Science. 2012 Dec 7;338(6112):1285. doi: 10.1126/science.338.6112.1285-a.


PMID- 23224529
OWN - NLM
STAT- MEDLINE
DCOM- 20121217
LR  - 20130304
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Linking)
VI  - 338
IP  - 6112
DP  - 2012 Dec 7
TI  - Scientific ethics. Final report on Stapel also blames field as a whole.
PG  - 1270-1
LID - 10.1126/science.338.6112.1270 [doi]
FAU - Enserink, Martin
AU  - Enserink M
LA  - eng
PT  - News
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
SB  - IM
EIN - Science. 2013 Mar 1;339(6123):1033
MH  - Psychology, Social/*ethics
MH  - *Scientific Misconduct
EDAT- 2012/12/12 06:00
MHDA- 2012/12/18 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2012/12/18 06:00 [medline]
AID - 338/6112/1270 [pii]
AID - 10.1126/science.338.6112.1270 [doi]
PST - ppublish
SO  - Science. 2012 Dec 7;338(6112):1270-1. doi: 10.1126/science.338.6112.1270.


PMID- 23223744
OWN - NLM
STAT- MEDLINE
DCOM- 20130226
LR  - 20190911
IS  - 0080-6234 (Print)
IS  - 0080-6234 (Linking)
VI  - 46
IP  - 5
DP  - 2012 Oct
TI  - [A training course on bioethics for Family Health Strategy professionals in Santo
      Andre, SP].
PG  - 1248-53
LID - S0080-62342012000500029 [pii]
AB  - This case report presents the experience of a training course on bioethics for
      nurses and physicians of the Family Health Strategy in Santo Andre, SP. This
      study is based on problem-based learning and deliberative bioethics, and aimed at
      presenting the deliberation procedure as a means of handling ethical issues.
      Contents were addressed in a cross-section manner through five sequential
      activity sessions at two different moments of concentration with one dispersion
      interval. In the first moment of concentration, key concepts and deliberative
      bioethics contents were developed. The second involved deliberation sessions on
      moral conflicts, which were selected and prepared during the dispersion interval.
      Participants evaluated the deliberation as an appropriate instrument to deal with
      the ethical issues they are faced with. Problem-based learning was an effective
      educational strategy for continuing education in deliberative bioethics.
FAU - Zoboli, Elma Lourdes Campos Pavone
AU  - Zoboli EL
AD  - Departamento de Enfermagem em Saude Coletiva, Universidade de Sao Paulo, Sao
      Paulo, Brasil. elma@usp.br
FAU - Soares, Fatima Aparecida Cotrim
AU  - Soares FA
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Capacitacao em bioetica para profissionais da Saude da Familia do municipio de
      Santo Andre, SP.
PL  - Brazil
TA  - Rev Esc Enferm USP
JT  - Revista da Escola de Enfermagem da U S P
JID - 0242726
MH  - Bioethics/*education
MH  - Brazil
MH  - *Family Health
MH  - Health Personnel/*education
EDAT- 2012/12/12 06:00
MHDA- 2013/02/27 06:00
CRDT- 2012/12/11 06:00
PHST- 2010/10/15 00:00 [received]
PHST- 2012/03/28 00:00 [accepted]
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/02/27 06:00 [medline]
AID - S0080-62342012000500029 [pii]
AID - 10.1590/s0080-62342012000500029 [doi]
PST - ppublish
SO  - Rev Esc Enferm USP. 2012 Oct;46(5):1248-53. doi: 10.1590/s0080-62342012000500029.


PMID- 23223730
OWN - NLM
STAT- MEDLINE
DCOM- 20130226
LR  - 20190911
IS  - 0080-6234 (Print)
IS  - 0080-6234 (Linking)
VI  - 46
IP  - 5
DP  - 2012 Oct
TI  - [Family functionality regarding the elderly with cognitive impairments: the
      caretaker's perception].
PG  - 1141-7
LID - S0080-62342012000500015 [pii]
AB  - The objectives of this study were to characterize the caregivers of elderly
      individuals with cognitive impairment living in different contexts of social
      vulnerability, and assess the family functionality of the elderly as perceived by
      the caregivers. Family functionality was evaluated using the Family APGAR
      instrument, assessed during home interviews with 72 caretakers. All the ethical
      aspects were observed. Spearman's correlation and the Mann-Whitney test were
      used, with 5% significance level (p<0.05). Results show that 82% of caregivers
      reported a good family functionality, 14% reported moderate family dysfunction,
      and 4% reported high family dysfunction. A statistically significant correlation 
      was found between Family APGAR and the number of people living in the house
      (p=0.048). Further studies could verify the relationship between family
      functionality and the caretaker's overload in the context of elderly persons with
      dementia.
FAU - dos Santos, Ariene Angelini
AU  - dos Santos AA
AD  - Departamento de Enfermagem, Universidade Federal de Sao Carlos, Sao Carlos,
      Brasil. sofia@ufscar.br
FAU - Pavarini, Sofia Cristina Iost
AU  - Pavarini SC
LA  - por
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
TT  - Funcionalidade familiar de idosos com alteracoes cognitivas: a percepcao do
      cuidador.
PL  - Brazil
TA  - Rev Esc Enferm USP
JT  - Revista da Escola de Enfermagem da U S P
JID - 0242726
MH  - Adult
MH  - Aged
MH  - Caregivers/*psychology
MH  - *Cognition Disorders
MH  - Cross-Sectional Studies
MH  - *Family Relations
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
EDAT- 2012/12/12 06:00
MHDA- 2013/02/27 06:00
CRDT- 2012/12/11 06:00
PHST- 2011/04/27 00:00 [received]
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/02/27 06:00 [medline]
AID - S0080-62342012000500015 [pii]
AID - 10.1590/s0080-62342012000500015 [doi]
PST - ppublish
SO  - Rev Esc Enferm USP. 2012 Oct;46(5):1141-7. doi: 10.1590/s0080-62342012000500015.


PMID- 23223615
OWN - NLM
STAT- MEDLINE
DCOM- 20130606
LR  - 20211021
IS  - 1754-8411 (Electronic)
IS  - 1754-8403 (Linking)
VI  - 6
IP  - 1
DP  - 2013 Jan
TI  - The armadillo: a model for the neuropathy of leprosy and potentially other
      neurodegenerative diseases.
PG  - 19-24
LID - 10.1242/dmm.010215 [doi]
AB  - Leprosy (also known as Hansen's disease) is an infectious peripheral neurological
      disorder caused by Mycobacterium leprae that even today leaves millions of
      individuals worldwide with life-long disabilities. The specific mechanisms by
      which this bacterium induces nerve injury remain largely unknown, mainly owing to
      ethical and practical limitations in obtaining affected human nerve samples. In
      addition to humans, nine-banded armadillos (Dasypus novemcinctus) are the only
      other natural host of M. leprae, and they develop a systemically disseminated
      disease with extensive neurological involvement. M. leprae is an obligate
      intracellular parasite that cannot be cultivated in vitro. Because of the heavy
      burdens of bacilli they harbor, nine-banded armadillos have become the organism
      of choice for propagating large quantities of M. leprae, and they are now
      advancing as models of leprosy pathogenesis and nerve damage. Although armadillos
      are exotic laboratory animals, the recently completed whole genome sequence for
      this animal is enabling researchers to undertake more sophisticated molecular
      studies and to develop armadillo-specific reagents. These advances will
      facilitate the use of armadillos in piloting new therapies and diagnostic
      regimens, and will provide new insights into the oldest known infectious
      neurodegenerative disorder.
FAU - Sharma, Rahul
AU  - Sharma R
AD  - Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana 
      State University, Baton Rouge, LA 70803, USA.
FAU - Lahiri, Ramanuj
AU  - Lahiri R
FAU - Scollard, David M
AU  - Scollard DM
FAU - Pena, Maria
AU  - Pena M
FAU - Williams, Diana L
AU  - Williams DL
FAU - Adams, Linda B
AU  - Adams LB
FAU - Figarola, John
AU  - Figarola J
FAU - Truman, Richard W
AU  - Truman RW
LA  - eng
GR  - IAA-2646/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
DEP - 20121205
PL  - England
TA  - Dis Model Mech
JT  - Disease models & mechanisms
JID - 101483332
SB  - IM
MH  - Animal Husbandry
MH  - Animals
MH  - *Armadillos/genetics/microbiology
MH  - Disease Models, Animal
MH  - Humans
MH  - Leprosy/diagnosis/*etiology/microbiology/therapy
MH  - Mycobacterium leprae/pathogenicity
MH  - Neurodegenerative Diseases/*etiology/microbiology
MH  - Species Specificity
PMC - PMC3529335
EDAT- 2012/12/12 06:00
MHDA- 2013/06/07 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/06/07 06:00 [medline]
AID - dmm.010215 [pii]
AID - 10.1242/dmm.010215 [doi]
PST - ppublish
SO  - Dis Model Mech. 2013 Jan;6(1):19-24. doi: 10.1242/dmm.010215. Epub 2012 Dec 5.


PMID- 23223604
OWN - NLM
STAT- MEDLINE
DCOM- 20130909
LR  - 20220331
IS  - 1537-6591 (Electronic)
IS  - 1058-4838 (Linking)
VI  - 56
IP  - 8
DP  - 2013 Apr
TI  - Preexposure prophylaxis for adolescents and young adults at risk for HIV
      infection: is an ounce of prevention worth a pound of cure?
PG  - 1149-55
LID - 10.1093/cid/cis1020 [doi]
AB  - An alarming proportion of incident human immunodeficiency virus (HIV) infections 
      worldwide occur in youth. In the United States, 69% of all new infections among
      youth occurred in young men who have sex with men (YMSM). Recent studies show the
      promise of preexposure prophylaxis (PrEP) for preventing HIV infection, but
      research efforts suffer from disproportionately low representation of the youth
      who are most at risk. Youth-focused research is critical and should include
      behavioral, community, and biomedical interventions to create a comprehensive HIV
      prevention package. The many ethical, legal, and regulatory considerations in
      conducting HIV research among, and in providing care services to, youth must be
      addressed so that those at high risk and most likely to benefit can have
      unfettered access to safe and effective health-promoting interventions. YMSM and 
      minority youth are at substantial HIV risk and urgently need effective HIV
      prevention tools for which the short and long-term benefits and risks have been
      carefully considered.
FAU - Pace, Jill E
AU  - Pace JE
AD  - Pediatric, Adolescent and Maternal AIDS Branch, Eunice Kennedy Shriver National
      Institute of Child Health and Human Development, National Institutes of Health,
      Bethesda, Maryland 20892-7510, USA.
FAU - Siberry, George K
AU  - Siberry GK
FAU - Hazra, Rohan
AU  - Hazra R
FAU - Kapogiannis, Bill G
AU  - Kapogiannis BG
LA  - eng
PT  - Journal Article
DEP - 20121207
PL  - United States
TA  - Clin Infect Dis
JT  - Clinical infectious diseases : an official publication of the Infectious Diseases
      Society of America
JID - 9203213
RN  - 0 (Anti-HIV Agents)
SB  - IM
CIN - Clin Infect Dis. 2013 Apr;56(8):1156-8. PMID: 23223593
MH  - Adolescent
MH  - Adult
MH  - African Americans
MH  - Anti-HIV Agents/economics/therapeutic use
MH  - Communicable Disease Control/economics/legislation & jurisprudence
MH  - Female
MH  - HIV Infections/drug therapy/*prevention & control
MH  - Homosexuality, Male
MH  - Humans
MH  - Male
MH  - Primary Prevention/*economics/ethics/legislation & jurisprudence
MH  - Risk
MH  - United States
MH  - Young Adult
PMC - PMC3657491
EDAT- 2012/12/12 06:00
MHDA- 2013/09/10 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/09/10 06:00 [medline]
AID - cis1020 [pii]
AID - 10.1093/cid/cis1020 [doi]
PST - ppublish
SO  - Clin Infect Dis. 2013 Apr;56(8):1149-55. doi: 10.1093/cid/cis1020. Epub 2012 Dec 
      7.


PMID- 23223564
OWN - NLM
STAT- MEDLINE
DCOM- 20130502
LR  - 20220129
IS  - 1472-4146 (Electronic)
IS  - 0021-9746 (Linking)
VI  - 66
IP  - 4
DP  - 2013 Apr
TI  - Consent of the recently bereaved to post-mortem targeted angiography research:
      207 adult cases.
PG  - 326-9
LID - 10.1136/jclinpath-2012-201250 [doi]
AB  - AIMS: To present our experience of prospective telephone consenting for
      post-mortem CT angiography (PMCT-A) research using HM coroners' cases. METHODS:
      Local ethics committee, research and development office, and local HM coroners
      gave their permission for the families of the deceased, in cases where a
      'routine' coroner's autopsy had been authorised, to be approached for their
      consent to PMCT-A research before the autopsy examination. A forensic pathologist
      or trial consenter telephoned the next of kin, discussed the nature of the study 
      and obtained verbal informed consent for post-mortem imaging, angiography,
      case-dependent histological and toxicology sampling and for the use of the images
      for teaching and training. Thematic analyses of the reasons for giving or
      refusing consent are provided. RESULTS: Of the 207 cases approached, seven
      relatives refused to enter their next of kin into the study (96.6% consent rate).
      CONCLUSIONS: This study shows that prospective consenting for HM coroners' cases 
      to be used for autopsy research is feasible in adults, and can be done ethically,
      and in the limited time available, by obtaining the consent of the next of kin by
      telephone before autopsy.
FAU - Saunders, Sarah L
AU  - Saunders SL
AD  - East Midlands Forensic Pathology Unit, University of Leicester, Leicester Royal
      Infirmary, Leicester, UK. gnr3@le.ac.uk
FAU - Amoroso, Jasmin
AU  - Amoroso J
FAU - Morgan, Bruno
AU  - Morgan B
FAU - Rutty, Guy
AU  - Rutty G
LA  - eng
GR  - RC-PG-0309-10052/DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121208
PL  - England
TA  - J Clin Pathol
JT  - Journal of clinical pathology
JID - 0376601
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Angiography/ethics/*methods
MH  - Attitude to Death
MH  - Autopsy
MH  - *Bereavement
MH  - *Biomedical Research/ethics
MH  - Coroners and Medical Examiners
MH  - England
MH  - Family/*psychology
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - *Research Subjects
MH  - Telephone
MH  - *Third-Party Consent
MH  - Time Factors
MH  - *Tomography, X-Ray Computed/ethics
EDAT- 2012/12/12 06:00
MHDA- 2013/05/03 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/05/03 06:00 [medline]
AID - jclinpath-2012-201250 [pii]
AID - 10.1136/jclinpath-2012-201250 [doi]
PST - ppublish
SO  - J Clin Pathol. 2013 Apr;66(4):326-9. doi: 10.1136/jclinpath-2012-201250. Epub
      2012 Dec 8.


PMID- 23223340
OWN - NLM
STAT- MEDLINE
DCOM- 20130606
LR  - 20220409
IS  - 1523-5866 (Electronic)
IS  - 1522-8517 (Linking)
VI  - 15
IP  - 1
DP  - 2013 Jan
TI  - Outcome and molecular characteristics of adolescent and young adult patients with
      newly diagnosed primary glioblastoma: a study of the Society of Austrian
      Neurooncology (SANO).
PG  - 112-21
LID - 10.1093/neuonc/nos283 [doi]
AB  - BACKGROUND: Young age is a favorable prognostic factor for patients with
      glioblastoma multiforme (GBM). We reviewed the outcomes and molecular tumor
      characteristics of adolescent and young adult patients with GBM treated in 2
      Austrian centers. PATIENTS AND METHODS: Data on patients with histologically
      proven primary GBM diagnosed from 18 through 40 years of age were retrospectively
      analyzed. All patients were treated with standard first-line therapy. The primary
      end points were overall survival (OS) and time to progression (TTP). IDH1-R132H
      mutation status was analyzed using immunohistochemistry, and MGMT promoter
      methylation was assessed using methylation-specific polymerase chain reaction.
      RESULTS: We included 70 patients (36 men and 34 women) with a median age of 33
      years. IDH1-R132H mutations were detected in 22 (39.3%) of 56 cases and MGMT
      promoter methylation in 33 (61.1%) of 54 cases with available tissue samples. In 
      patients with wild-type IDH, median TTP was 8.2 months and median OS was 24
      months, compared with 18 months and 44 months, respectively, observed in patients
      with mutated IDH. Neither IDH1 nor MGMT status showed a statistically significant
      association with TTP or OS. Of note, the social and economical situation of the
      young patients with GBM was alarming, because only 17% succeeded in staying
      employed after receiving the diagnosis. CONCLUSIONS: We found a high frequency of
      IDH1 mutations and MGMT promoter methylation among young adult patients with
      primary GBM that may contribute to the generally favorable outcome associated
      with young age. The social and economic coverage of patients with glioma remains 
      an unsolved socio-ethical problem.
FAU - Leibetseder, Annette
AU  - Leibetseder A
AD  - Department of Medicine I, Division of Oncology, Medical University of Vienna,
      Vienna, Austria.
FAU - Ackerl, Michael
AU  - Ackerl M
FAU - Flechl, Birgit
AU  - Flechl B
FAU - Wohrer, Adelheid
AU  - Wohrer A
FAU - Widhalm, Georg
AU  - Widhalm G
FAU - Dieckmann, Karin
AU  - Dieckmann K
FAU - Kreinecker, Sabine-Spiegl
AU  - Kreinecker SS
FAU - Pichler, Josef
AU  - Pichler J
FAU - Hainfellner, Johannes
AU  - Hainfellner J
FAU - Preusser, Matthias
AU  - Preusser M
FAU - Marosi, Christine
AU  - Marosi C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121207
PL  - England
TA  - Neuro Oncol
JT  - Neuro-oncology
JID - 100887420
RN  - 0 (Tumor Suppressor Proteins)
RN  - EC 1.1.1.41 (Isocitrate Dehydrogenase)
RN  - EC 1.1.1.42. (IDH1 protein, human)
RN  - EC 2.1.1.- (DNA Modification Methylases)
RN  - EC 2.1.1.63 (MGMT protein, human)
RN  - EC 6.5.1.- (DNA Repair Enzymes)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain Neoplasms/diagnosis/*genetics/mortality
MH  - *DNA Methylation
MH  - DNA Modification Methylases/*genetics
MH  - DNA Repair Enzymes/*genetics
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Glioblastoma/diagnosis/*genetics/mortality
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Isocitrate Dehydrogenase/*genetics/metabolism
MH  - Male
MH  - Mutation/*genetics
MH  - Neoplasm Recurrence, Local/diagnosis/*genetics/mortality
MH  - Prognosis
MH  - Promoter Regions, Genetic
MH  - Retrospective Studies
MH  - Survival Rate
MH  - Tumor Suppressor Proteins/*genetics
MH  - Young Adult
PMC - PMC3534426
EDAT- 2012/12/12 06:00
MHDA- 2013/06/07 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/06/07 06:00 [medline]
AID - nos283 [pii]
AID - 10.1093/neuonc/nos283 [doi]
PST - ppublish
SO  - Neuro Oncol. 2013 Jan;15(1):112-21. doi: 10.1093/neuonc/nos283. Epub 2012 Dec 7.


PMID- 23222144
OWN - NLM
STAT- MEDLINE
DCOM- 20130812
LR  - 20130521
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 6
DP  - 2013 Jun
TI  - A European consistency for functioning of RECs? We just lost our chance.
PG  - 408-9
LID - 10.1136/medethics-2012-101228 [doi]
AB  - On 17 July 2012, the European Commission formally adopted a proposal for a new
      European Union (EU) Directive regarding clinical trials, which will repeal and
      replace the existing Directive 2001/20/EC. The main reasons for the revision
      were: (1) the decreasing number of clinical trials in the region and (2) harsh
      criticism of the present version of the Directive. The proposed regulation could 
      simplify the rules for conducting clinical trials and also rebuild the entire
      system of clinical trial assessment. However, it seems that we probably have
      already lost our chance regarding the consistency and quality of functioning of
      research ethics committees in the EU.
FAU - Waligora, Marcin
AU  - Waligora M
AD  - Department of Philosophy and Bioethics, Jagiellonian University, Medical College,
      Michalowskiego 12, Krakow 31-126, Poland. m.waligora@uj.edu.pl
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121208
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Clinical Trials as Topic/*standards
MH  - Ethics Committees, Research
MH  - Ethics, Research
MH  - *European Union
MH  - Humans
MH  - Informed Consent/ethics/standards
MH  - *International Cooperation
MH  - Practice Guidelines as Topic/*standards
OTO - NOTNLM
OT  - Clinical trials
OT  - Commissions/Councils
OT  - Drugs and Drug Industry
OT  - Ethics Committees/Consultation
OT  - Research Ethics
EDAT- 2012/12/12 06:00
MHDA- 2013/08/13 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/08/13 06:00 [medline]
AID - medethics-2012-101228 [pii]
AID - 10.1136/medethics-2012-101228 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Jun;39(6):408-9. doi: 10.1136/medethics-2012-101228. Epub 2012
      Dec 8.


PMID- 23222143
OWN - NLM
STAT- MEDLINE
DCOM- 20130429
LR  - 20211021
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 3
DP  - 2013 Mar
TI  - Elective ventilation for organ donation: law, policy and public ethics.
PG  - 130-4
LID - 10.1136/medethics-2012-100992 [doi]
AB  - This paper examines questions concerning elective ventilation, contextualised
      within English law and policy. It presents the general debate with reference both
      to the Exeter Protocol on elective ventilation, and the considerable developments
      in legal principle since the time that that protocol was declared to be unlawful.
      I distinguish different aspects of what might be labelled elective ventilation
      policies under the following four headings: 'basic elective ventilation';
      'epistemically complex elective ventilation'; 'practically complex elective
      ventilation'; and 'epistemically and practically complex elective ventilation'. I
      give a legal analysis of each. In concluding remarks on their potential practical
      viability, I emphasise the importance not just of ascertaining the legal and
      ethical acceptability of these and other forms of elective ventilation, but also 
      of assessing their professional and political acceptability. This importance
      relates both to the successful implementation of the individual practices, and to
      guarding against possible harmful effects in the wider efforts to increase the
      rates of posthumous organ donation.
FAU - Coggon, John
AU  - Coggon J
AD  - Southampton Law School, University of Southampton, Southampton, SO17 1BJ, UK.
      john.coggon@soton.ac.uk
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - WT087439/Z/08/Z/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121207
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
CIN - J Med Ethics. 2013 Mar;39(3):129. PMID: 23423179
MH  - *Brain Death
MH  - Critical Care/ethics
MH  - Humans
MH  - Intensive Care Units
MH  - Life Support Care/ethics/*legislation & jurisprudence
MH  - *Medical Futility
MH  - Organ Transplantation/legislation & jurisprudence
MH  - Patient Admission
MH  - Respiration, Artificial/*ethics
MH  - *Third-Party Consent
MH  - Tissue Donors/*supply & distribution
MH  - Tissue and Organ Harvesting/ethics/*legislation & jurisprudence
MH  - Tissue and Organ Procurement/ethics/*legislation & jurisprudence
MH  - Uncertainty
MH  - United Kingdom
PMC - PMC3948088
EDAT- 2012/12/12 06:00
MHDA- 2013/04/30 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/04/30 06:00 [medline]
AID - medethics-2012-100992 [pii]
AID - 10.1136/medethics-2012-100992 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Mar;39(3):130-4. doi: 10.1136/medethics-2012-100992. Epub 2012
      Dec 7.


PMID- 23222113
OWN - NLM
STAT- MEDLINE
DCOM- 20130524
LR  - 20121211
IS  - 1535-1815 (Electronic)
IS  - 0749-5161 (Linking)
VI  - 28
IP  - 12
DP  - 2012 Dec
TI  - IT in the ED: a new section of Pediatric Emergency Care.
PG  - 1399-401
LID - 10.1097/PEC.0b013e31827d909e [doi]
AB  - Information technology (IT) has profoundly changed the delivery of health care
      during the past decade. The pediatric emergency department (ED) represents a
      specific challenge for applying IT systems to the patient bedside. The rapid pace
      and unscheduled nature of the ED, the breadth of care delivered, and the range of
      medical, ethical, cultural, and process issues presented by pediatric patients
      make this a setting in particular need of thoughtfully designed and usable IT
      systems. However, reviews of the current state of health IT have documented mixed
      outcomes, including safety risks introduced by IT systems, significant deficits
      in usability for clinicians, and unrealized potential. Although some publications
      have presented methods and outcomes of IT systems in the pediatric ED, the
      current medical literature is sparse. Professional organizations have not
      developed successful methods to share best practices across institutions and IT
      vendors. The authors propose a new section of this journal focused on the
      application of IT systems to Pediatric Emergency Care. The section will include
      original research articles and reviews focusing on the application of IT to
      improve care of acutely ill and injured children. Innovative approaches and
      articles by physicians in training are particularly encouraged to develop new
      expertise in informatics within this and related specialties.
FAU - Zorc, Joseph J
AU  - Zorc JJ
AD  - Division of Emergency Medicine, Children's Hospital of Philadelphia, University
      of Pennsylvania School of Medicine, Philadelphia, PA 19104-4399, USA.
      zorc@email.chop.edu
FAU - Hoffman, Jeffrey M
AU  - Hoffman JM
FAU - Harper, Marvin B
AU  - Harper MB
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pediatr Emerg Care
JT  - Pediatric emergency care
JID - 8507560
SB  - IM
MH  - Emergency Medicine/*trends
MH  - Emergency Service, Hospital/*trends
MH  - Forecasting
MH  - *Medical Informatics
MH  - Pediatrics/*trends
MH  - *Periodicals as Topic
EDAT- 2012/12/12 06:00
MHDA- 2013/05/28 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/05/28 06:00 [medline]
AID - 10.1097/PEC.0b013e31827d909e [doi]
AID - 00006565-201212000-00031 [pii]
PST - ppublish
SO  - Pediatr Emerg Care. 2012 Dec;28(12):1399-401. doi: 10.1097/PEC.0b013e31827d909e.


PMID- 23221951
OWN - NLM
STAT- MEDLINE
DCOM- 20131105
LR  - 20211021
IS  - 1936-959X (Electronic)
IS  - 0195-6108 (Linking)
VI  - 34
IP  - 6
DP  - 2013 Jun-Jul
TI  - Bisphosphonate-induced osteonecrosis of the jaw: comparison of disease extent on 
      contrast-enhanced MR imaging, [18F] fluoride PET/CT, and conebeam CT imaging.
PG  - 1242-7
LID - 10.3174/ajnr.A3355 [doi]
AB  - BACKGROUND AND PURPOSE: Imaging of bisphosphonate-induced osteonecrosis of the
      jaw is essential for surgical planning. We compared the extent of BONJ on
      contrast-enhanced MR imaging, [(18)F] fluoride PET/CT, and panoramic views
      derived from standard conebeam CT with clinical pre- and intraoperative
      examinations. MATERIALS AND METHODS: Between February 2011 and January 2012, ten 
      subjects with written informed consent (9 women; mean, 69.6 years; range, 53-88
      years) were included in this prospective ethics-board-approved study. Patients
      underwent CEMR imaging, [(18)F] fluoride PET/CT, and CBCT and were clinically
      examined pre- and intraoperatively. Surgery was performed, and BONJ was
      histologically confirmed in 9 patients. Location and extent of BONJ on different 
      modalities/examinations were graphically compared (0 = no pathologic finding, 1 =
      smallest, 5 = largest extent of BONJ). Rank tests were used to assess overall and
      paired differences of ratings in 9 patients. A P value <.05 was considered
      statistically significant. RESULTS: Significant differences in BONJ extent among 
      different modalities and examinations were found (P < .001). The highest median
      rank was seen in PET/CT (4 +/- 1.12) and CEMR imaging (4 +/- 1.01), followed by
      intraoperative examinations (3 +/- 0.71), CBCT (2 +/- 0.33), and preoperative
      examinations (1 +/- 0). No significant differences were found between PET/CT and 
      CEMR imaging (P = .23), except when comparing PET/CT to either CBCT, pre- and
      intraoperative examinations (all P < .05). Preoperative examinations showed
      significantly less extensive disease than all other modalities/examinations (all 
      P < .05). CONCLUSIONS: [(18)F] fluoride PET/CT and CEMR imaging revealed more
      extensive involvement of BONJ compared with panoramic views from CBCT and
      clinical examinations.
FAU - Guggenberger, R
AU  - Guggenberger R
AD  - Department of Diagnostic and Interventional Radiology, University Hospital
      Zurich, Ramistr 100, 8091 Zurich, Switzerland. roman.guggenberger@usz.ch
FAU - Fischer, D R
AU  - Fischer DR
FAU - Metzler, P
AU  - Metzler P
FAU - Andreisek, G
AU  - Andreisek G
FAU - Nanz, D
AU  - Nanz D
FAU - Jacobsen, C
AU  - Jacobsen C
FAU - Schmid, D T
AU  - Schmid DT
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
DEP - 20121206
PL  - United States
TA  - AJNR Am J Neuroradiol
JT  - AJNR. American journal of neuroradiology
JID - 8003708
RN  - 0 (Bone Density Conservation Agents)
RN  - 0 (Diphosphonates)
RN  - 0 (Radiopharmaceuticals)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Bisphosphonate-Associated Osteonecrosis of the Jaw/diagnostic imaging/pathology
MH  - Bone Density Conservation Agents/adverse effects
MH  - Diphosphonates/*adverse effects
MH  - Female
MH  - Fluorodeoxyglucose F18
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Multimodal Imaging/*methods
MH  - *Positron-Emission Tomography
MH  - Prospective Studies
MH  - Radiopharmaceuticals
MH  - Tomography, X-Ray Computed/*methods
PMC - PMC7964583
EDAT- 2012/12/12 06:00
MHDA- 2013/11/06 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/11/06 06:00 [medline]
AID - ajnr.A3355 [pii]
AID - 10.3174/ajnr.A3355 [doi]
PST - ppublish
SO  - AJNR Am J Neuroradiol. 2013 Jun-Jul;34(6):1242-7. doi: 10.3174/ajnr.A3355. Epub
      2012 Dec 6.


PMID- 23221848
OWN - NLM
STAT- MEDLINE
DCOM- 20130510
LR  - 20121210
IS  - 1538-6899 (Electronic)
IS  - 1080-2371 (Linking)
VI  - 18
IP  - 6 Infectious Disease
DP  - 2012 Dec
TI  - An HIV testing conundrum: balancing the health and privacy considerations of
      multiple stakeholders.
PG  - 1417-21
LID - 10.1212/01.CON.0000423854.47770.5e [doi]
AB  - Legal standards for HIV testing are evolving in an attempt to achieve an ethical 
      equilibrium between the privacy rights of infected or potentially infected
      individuals and public health considerations that seek to limit the spread and
      severity of the disease through early recognition and treatment. Although guided 
      by US Centers for Disease Control and Prevention recommendations, these standards
      are determined by state law. In this case, an ethical dilemma is presented and
      discussed in which the privacy interests of an HIV-infected individual come into 
      conflict with the health considerations of an inadvertently exposed neurology
      resident and her unborn child, a conundrum amplified by the restricted HIV
      testing laws of the state in which the incident took place.
FAU - Russell, James A
AU  - Russell JA
AD  - Lahey Clinic Medical Center, Department of Neurology, 41 Mall Road, Burlington,
      MA 01805, USA. james.a.russell@lahey.org
FAU - Nelson, Sarah Bird
AU  - Nelson SB
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Continuum (Minneap Minn)
JT  - Continuum (Minneapolis, Minn.)
JID - 9509333
SB  - IM
MH  - AIDS Serodiagnosis/*ethics
MH  - Adult
MH  - Confidentiality/*ethics
MH  - Duty to Warn
MH  - Female
MH  - HIV Infections/*diagnosis
MH  - Humans
MH  - Internship and Residency/ethics
MH  - *Needlestick Injuries
MH  - Occupational Diseases/virology
MH  - Seizures/virology
MH  - Treatment Refusal/ethics
EDAT- 2012/12/12 06:00
MHDA- 2013/05/11 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/05/11 06:00 [medline]
AID - 10.1212/01.CON.0000423854.47770.5e [doi]
AID - 00132979-201212000-00015 [pii]
PST - ppublish
SO  - Continuum (Minneap Minn). 2012 Dec;18(6 Infectious Disease):1417-21. doi:
      10.1212/01.CON.0000423854.47770.5e.


PMID- 23221292
OWN - NLM
STAT- MEDLINE
DCOM- 20130227
LR  - 20211021
IS  - 1557-0541 (Print)
IS  - 1557-0541 (Linking)
VI  - 6
IP  - 4
DP  - 2012 Winter
TI  - Community-university partnerships in community-based research.
PG  - 463-9
LID - 10.1353/cpr.2012.0053 [doi]
AB  - PROBLEM: Community-engaged research (CEnR) is a complex, collaborative process
      that presents many challenges and requires investment of time and commitment by
      both community and university research partners. PURPOSE: This paper describes
      the experience of a group of university and community members developing a set of
      guidelines for the ethical conduct of CEnR projects. KEY POINTS: The paper
      outlines the process of guideline development and lessons learned from this
      collaborative effort, which was based upon approaches and methods of
      community-based participatory research (CBPR). CONCLUSIONS: The guidelines are
      included and may serve as a framework to be individualized by other partnerships.
      Our experience shows that the very process of review, revision, and engagement is
      extremely helpful in creating a framework that works for the specific communities
      and for establishing working relationships among the partners so that all
      stakeholders feel ownership and investment in the framework and the collaborative
      research efforts.
FAU - Sadler, Lois S
AU  - Sadler LS
AD  - Yale University School of Nursing.
FAU - Larson, Jean
AU  - Larson J
FAU - Bouregy, Susan
AU  - Bouregy S
FAU - Lapaglia, Donna
AU  - Lapaglia D
FAU - Bridger, Laurie
AU  - Bridger L
FAU - McCaslin, Catherine
AU  - McCaslin C
FAU - Rockwell, Sara
AU  - Rockwell S
LA  - eng
GR  - UL1 RR024139/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Prog Community Health Partnersh
JT  - Progress in community health partnerships : research, education, and action
JID - 101273946
SB  - IM
MH  - Community Participation
MH  - Community-Based Participatory Research/ethics/*organization & administration
MH  - *Community-Institutional Relations
MH  - Cooperative Behavior
MH  - Decision Making
MH  - Ethics, Research
MH  - *Guidelines as Topic
MH  - Humans
MH  - Universities/*organization & administration
PMC - PMC3579553
MID - NIHMS439559
EDAT- 2012/12/12 06:00
MHDA- 2013/02/28 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/02/28 06:00 [medline]
AID - S1557055X12400092 [pii]
AID - 10.1353/cpr.2012.0053 [doi]
PST - ppublish
SO  - Prog Community Health Partnersh. 2012 Winter;6(4):463-9. doi:
      10.1353/cpr.2012.0053.


PMID- 23220423
OWN - NLM
STAT- MEDLINE
DCOM- 20131216
LR  - 20220409
IS  - 1555-905X (Electronic)
IS  - 1555-9041 (Linking)
VI  - 8
IP  - 5
DP  - 2013 May
TI  - Nephrologists' professional ethics in dialysis practices.
PG  - 840-4
LID - 10.2215/CJN.08490812 [doi]
AB  - Although the number of incidents is unknown, professional quality-oriented renal 
      organizations have become aware of an increased number of complaints regarding
      nephrologists who approach patients with the purpose of influencing patients to
      change nephrologists or dialysis facilities (hereinafter referred to as patient
      solicitation). This development prompted the Forum of ESRD Networks and the Renal
      Physicians Association to publish a policy statement on professionalism and
      ethics in medical practice as these concepts relate to patient solicitation. Also
      common but not new is the practice of nephrologists trying to recruit their own
      patients to a new dialysis unit in which they have a financial interest. This
      paper presents two illustrative cases and provides an ethical framework for
      analyzing patient solicitation and physician conflict of interest. This work
      concludes that, in the absence of objective data that medical treatment is better
      elsewhere, nephrologists who attempt to influence patients to change
      nephrologists or dialysis facilities fall short of accepted ethical standards
      pertaining to professional conduct, particularly with regard to the
      physician-patient relationship, informed consent, continuity of care, and
      conflict of interest.
FAU - Ozar, David T
AU  - Ozar DT
AD  - Center for Health Ethics and Law, West Virginia University, Morgantown, West
      Virginia 26506-9022, USA.
FAU - Kristensen, Cynthia
AU  - Kristensen C
FAU - Fadem, Stephen Z
AU  - Fadem SZ
FAU - Blaser, Robert
AU  - Blaser R
FAU - Singer, Dale
AU  - Singer D
FAU - Moss, Alvin H
AU  - Moss AH
LA  - eng
PT  - Journal Article
DEP - 20121206
PL  - United States
TA  - Clin J Am Soc Nephrol
JT  - Clinical journal of the American Society of Nephrology : CJASN
JID - 101271570
SB  - IM
MH  - Conflict of Interest
MH  - Continuity of Patient Care/ethics
MH  - Dialysis/economics/*ethics
MH  - *Ethics, Medical
MH  - Humans
MH  - Informed Consent/ethics
MH  - Marketing of Health Services/ethics
MH  - Nephrology/economics/*ethics
MH  - Physician-Patient Relations/ethics
MH  - Physicians/economics/*ethics
MH  - Professional Misconduct/*ethics
EDAT- 2012/12/12 06:00
MHDA- 2013/12/18 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
AID - CJN.08490812 [pii]
AID - 10.2215/CJN.08490812 [doi]
PST - ppublish
SO  - Clin J Am Soc Nephrol. 2013 May;8(5):840-4. doi: 10.2215/CJN.08490812. Epub 2012 
      Dec 6.


PMID- 23219679
OWN - NLM
STAT- MEDLINE
DCOM- 20140306
LR  - 20181202
IS  - 1873-6513 (Electronic)
IS  - 0885-3924 (Linking)
VI  - 46
IP  - 3
DP  - 2013 Sep
TI  - Intentional sedation to unconsciousness at the end of life: findings from a
      national physician survey.
PG  - 326-34
LID - 10.1016/j.jpainsymman.2012.09.007 [doi]
LID - S0885-3924(12)00748-8 [pii]
AB  - CONTEXT: The terms "palliative sedation" and "terminal sedation" have been used
      to refer to both proportionate palliative sedation, in which unconsciousness is a
      foreseen but unintended side effect, and palliative sedation to unconsciousness, 
      in which physicians aim to make their patients unconscious until death. It has
      not been clear to what extent palliative sedation to unconsciousness is accepted 
      and practiced by U.S. physicians. OBJECTIVES: To investigate U.S. physician
      acceptance and practice of palliative sedation to unconsciousness and to identify
      predictors of that practice. METHODS: In 2010, a survey was mailed to 2016
      practicing U.S. physicians. Criterion measures included self-reported practice of
      palliative sedation to unconsciousness until death and physician endorsement of
      such sedation for a hypothetical patient with existential suffering at the end of
      life. RESULTS: Of the 1880 eligible physicians, 1156 responded to the survey
      (62%). One in ten (141/1156) physicians had sedated a patient in the previous 12 
      months with the specific intention of making the patient unconscious until death,
      and two of three physicians opposed sedation to unconsciousness for existential
      suffering, both in principle (68%, n = 773) and in the case of a hypothetical
      dying patient (72%, n = 831). Eighty-five percent (n = 973) of physicians agreed 
      that unconsciousness is an acceptable side effect of palliative sedation but
      should not be directly intended. CONCLUSION: Although there is widespread support
      among U.S. physicians for proportionate palliative sedation, intentionally
      sedating dying patients to unconsciousness until death is neither the norm in
      clinical practice nor broadly supported for the treatment of primarily
      existential suffering.
CI  - Copyright (c) 2013 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. 
      All rights reserved.
FAU - Putman, Michael S
AU  - Putman MS
AD  - Pritzker School of Medicine, The University of Chicago, Chicago, Illinois, USA.
FAU - Yoon, John D
AU  - Yoon JD
FAU - Rasinski, Kenneth A
AU  - Rasinski KA
FAU - Curlin, Farr A
AU  - Curlin FA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121207
PL  - United States
TA  - J Pain Symptom Manage
JT  - Journal of pain and symptom management
JID - 8605836
SB  - IM
MH  - *Attitude of Health Personnel
MH  - *Attitude to Death
MH  - *Data Collection
MH  - Deep Sedation/*statistics & numerical data
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Palliative Care/*statistics & numerical data
MH  - Physicians/*statistics & numerical data
MH  - Practice Patterns, Physicians'/*statistics & numerical data
MH  - Stress, Psychological/*epidemiology/*prevention & control
MH  - Terminal Care/*statistics & numerical data
MH  - United States/epidemiology
OTO - NOTNLM
OT  - Ethics
OT  - end-of-life care
OT  - palliative care
OT  - palliative sedation
OT  - terminal sedation
EDAT- 2012/12/12 06:00
MHDA- 2014/03/07 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/07/11 00:00 [received]
PHST- 2012/09/06 00:00 [revised]
PHST- 2012/09/19 00:00 [accepted]
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2014/03/07 06:00 [medline]
AID - S0885-3924(12)00748-8 [pii]
AID - 10.1016/j.jpainsymman.2012.09.007 [doi]
PST - ppublish
SO  - J Pain Symptom Manage. 2013 Sep;46(3):326-34. doi:
      10.1016/j.jpainsymman.2012.09.007. Epub 2012 Dec 7.


PMID- 23219643
OWN - NLM
STAT- MEDLINE
DCOM- 20140107
LR  - 20181202
IS  - 1873-1465 (Electronic)
IS  - 0031-9406 (Linking)
VI  - 99
IP  - 2
DP  - 2013 Jun
TI  - Physiotherapists in emergency departments: responsibilities, accountability and
      education.
PG  - 95-100
LID - 10.1016/j.physio.2012.05.003 [doi]
LID - S0031-9406(12)00049-1 [pii]
AB  - Emergency physiotherapy roles have evolved within the UK and are increasingly
      being adopted in Australia in response to a need for greater workforce
      flexibility and improved service provision to meet growing patient demand. This
      paper discusses the need for the physiotherapy profession to develop
      evidence-based regulatory, ethical and educative frameworks to keep pace with the
      changing clinical environment and service delivery in emergency departments.
      Definitions of Emergency Physiotherapy as either advanced practice or extended
      scope of practice are identified, and the implications for both regulation of
      practice and education are highlighted. Suggestions for education in areas of
      clinical skills, ethical understanding and legal and professional knowledge are
      highlighted as important areas to support physiotherapists moving into this area 
      of practice.
CI  - Copyright (c) 2012 Chartered Society of Physiotherapy. Published by Elsevier Ltd.
      All rights reserved.
FAU - Crane, Jacqueline
AU  - Crane J
AD  - Emergency Department Austin Health, Heidelberg, Victoria 3084, Australia.
      jackie.crane@austin.org.au
FAU - Delany, Clare
AU  - Delany C
LA  - eng
PT  - Journal Article
DEP - 20120620
PL  - England
TA  - Physiotherapy
JT  - Physiotherapy
JID - 0401223
SB  - IM
MH  - Australia
MH  - Emergency Medical Services/*ethics/*methods
MH  - *Emergency Service, Hospital
MH  - Humans
MH  - Job Description
MH  - Physical Therapists/*education/*ethics/supply & distribution
MH  - Social Responsibility
MH  - Workforce
EDAT- 2012/12/12 06:00
MHDA- 2014/01/08 06:00
CRDT- 2012/12/11 06:00
PHST- 2011/11/25 00:00 [received]
PHST- 2012/05/25 00:00 [accepted]
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2014/01/08 06:00 [medline]
AID - S0031-9406(12)00049-1 [pii]
AID - 10.1016/j.physio.2012.05.003 [doi]
PST - ppublish
SO  - Physiotherapy. 2013 Jun;99(2):95-100. doi: 10.1016/j.physio.2012.05.003. Epub
      2012 Jun 20.


PMID- 23219165
OWN - NLM
STAT- MEDLINE
DCOM- 20130308
LR  - 20211021
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 77
DP  - 2013 Jan
TI  - The social dynamics of consent and refusal in HIV surveillance in rural South
      Africa.
PG  - 118-25
LID - 10.1016/j.socscimed.2012.11.015 [doi]
LID - S0277-9536(12)00764-2 [pii]
AB  - In the context of low rates of participation in a prospective, population-based
      HIV surveillance programme, researchers at a surveillance site in rural
      KwaZulu-Natal, South Africa, conducted an operational study from January 2009 to 
      February 2010, with the aim of improving participation rates, particularly in the
      provision of dried blood spots for the surveillance. Findings suggest, firstly,
      that consent to participation in the HIV surveillance is informed by the dynamics
      of relationality in the HIV surveillance "consent encounter." Secondly, it
      emerged that both fieldworkers and participants found it difficult to
      differentiate between HIV surveillance and HIV testing in the surveillance
      procedure, and tended to understand and explain giving blood under the aegis of
      the surveillance as an HIV test. The conflation of surveillance and testing, we
      argue, is not merely a semantic confusion, but reveals an important tension
      inherent to global health research between individual risks and benefits and
      collective good, or between private morality and public good. Because of these
      structural tensions, we suggest, the HIV surveillance consent encounter activates
      multiple gift economies in the collection of blood samples. Thinking beyond the
      complex ethical dimensions provoked by new forms of long-term surveillance and
      health research, we therefore suggest that deepening relations between
      scientists, fieldworkers, and study participants in locality deserve more careful
      methodological consideration and descriptive attention.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Reynolds, Lindsey
AU  - Reynolds L
AD  - Department of Anthropology, Johns Hopkins University, 3400 N. Charles St., 404
      Macauley Hall, Baltimore, MD 21218, United States. ljreynol@jhsph.edu
FAU - Cousins, Thomas
AU  - Cousins T
FAU - Newell, Marie-Louise
AU  - Newell ML
FAU - Imrie, John
AU  - Imrie J
LA  - eng
GR  - 097410/WT_/Wellcome Trust/United Kingdom
GR  - F31 MH084714/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121119
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - HIV Infections/*epidemiology
MH  - Health Services Research
MH  - Humans
MH  - Informed Consent/*statistics & numerical data
MH  - Male
MH  - Middle Aged
MH  - *Population Surveillance/methods
MH  - Prospective Studies
MH  - Qualitative Research
MH  - Rural Population/*statistics & numerical data
MH  - South Africa/epidemiology
MH  - Treatment Refusal/*statistics & numerical data
MH  - Young Adult
PMC - PMC3560061
EDAT- 2012/12/12 06:00
MHDA- 2013/03/09 06:00
CRDT- 2012/12/11 06:00
PHST- 2011/12/16 00:00 [received]
PHST- 2012/11/09 00:00 [revised]
PHST- 2012/11/13 00:00 [accepted]
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/03/09 06:00 [medline]
AID - S0277-9536(12)00764-2 [pii]
AID - 10.1016/j.socscimed.2012.11.015 [doi]
PST - ppublish
SO  - Soc Sci Med. 2013 Jan;77:118-25. doi: 10.1016/j.socscimed.2012.11.015. Epub 2012 
      Nov 19.


PMID- 23219137
OWN - NLM
STAT- MEDLINE
DCOM- 20130418
LR  - 20181202
IS  - 1769-6658 (Electronic)
IS  - 1278-3218 (Linking)
VI  - 17
IP  - 1
DP  - 2013 Feb
TI  - [Intensity modulated radiotherapy for head and neck cancers: ethics and patients 
      selection].
PG  - 1-9
LID - 10.1016/j.canrad.2012.10.009 [doi]
LID - S1278-3218(12)00415-5 [pii]
AB  - PURPOSE: Intensity modulated radiotherapy (IMRT) allows a better coverage of the 
      target volume and a better saving of organs at risk with a decrease of toxicity
      in head and neck cancers. It requires more human labor and materials compared to 
      conformational radiotherapy. If they are insufficient, a selection of the
      patients receiving IMRT may be necessary, raising an ethical problem. MATERIAL
      AND METHODS: We collected the motives guiding the choice of the technique of
      radiotherapy for head and neck cancers during a month of physicists' shortage.
      RESULTS: Nineteen patients received IMRT and eight conformational radiotherapy.
      Conformational irradiation was chosen in palliative and postsurgery treatments,
      to reduce delay, in laryngeal tumors and re-irradiation. IMRT was preferred for
      complex target volumes and the localizations at risk of important xerostomia
      following conformational radiotherapy. These choices were confronted with the
      bioethics criteria of Beauchamp and Childress. The beneficence justified the use 
      of IMRT or conformational radiotherapy depending on the circumstances. The
      non-maleficence attempted to decrease the toxicity with IMRT. Justice was
      questioned by the selection. The autonomy of patients was not totally respected
      in the choice. CONCLUSION: To help in the choice of the patients receiving an
      IMRT in a crisis situation, we proposed a hierarchical organization of selection 
      criteria: complex volumes close to critical organs at risk, localization with
      high risk of xerostomia, long life expectancy and postoperative delay
      constraints.
CI  - Copyright (c) 2012 Societe francaise de radiotherapie oncologique (SFRO).
      Published by Elsevier SAS. All rights reserved.
FAU - Renard-Oldrini, S
AU  - Renard-Oldrini S
AD  - Service de radiotherapie, centre Alexis-Vautrin, avenue de Bourgogne, 54500
      Vandoeuvre-les-Nancy, France. s.renard@nancy.unicancer.fr
FAU - Zielinski, A
AU  - Zielinski A
FAU - Mecellem, H
AU  - Mecellem H
FAU - Graff, P
AU  - Graff P
FAU - Marchesi, V
AU  - Marchesi V
FAU - Peiffert, D
AU  - Peiffert D
LA  - fre
PT  - Journal Article
TT  - Radiotherapie conformationnelle avec modulation d'intensite dans les cancers de
      la sphere ORL : ethique et selection des patients.
DEP - 20121203
PL  - France
TA  - Cancer Radiother
JT  - Cancer radiotherapie : journal de la Societe francaise de radiotherapie
      oncologique
JID - 9711272
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/radiotherapy
MH  - Decision Making
MH  - Female
MH  - France
MH  - Harm Reduction/*ethics
MH  - Head and Neck Neoplasms/*radiotherapy
MH  - Health Care Rationing/*ethics/legislation & jurisprudence/standards
MH  - *Health Physics
MH  - Health Services Accessibility/ethics/legislation & jurisprudence/*standards
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Motivation
MH  - Organ Sparing Treatments
MH  - Palliative Care
MH  - Patient Preference
MH  - Patient Rights
MH  - Patient Selection/*ethics
MH  - Personal Autonomy
MH  - Radiation Injuries/etiology/*prevention & control
MH  - Radiotherapy, Conformal/adverse effects/statistics & numerical data
MH  - Radiotherapy, Intensity-Modulated/adverse effects/*ethics/statistics & numerical 
      data
MH  - Retrospective Studies
MH  - Social Justice
MH  - Workforce
MH  - Xerostomia/etiology/*prevention & control
EDAT- 2012/12/12 06:00
MHDA- 2013/04/20 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/07/03 00:00 [received]
PHST- 2012/10/18 00:00 [revised]
PHST- 2012/10/18 00:00 [accepted]
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/04/20 06:00 [medline]
AID - S1278-3218(12)00415-5 [pii]
AID - 10.1016/j.canrad.2012.10.009 [doi]
PST - ppublish
SO  - Cancer Radiother. 2013 Feb;17(1):1-9. doi: 10.1016/j.canrad.2012.10.009. Epub
      2012 Dec 3.


PMID- 23219056
OWN - NLM
STAT- MEDLINE
DCOM- 20140911
LR  - 20220321
IS  - 1934-8150 (Electronic)
IS  - 1551-7411 (Linking)
VI  - 9
IP  - 6
DP  - 2013 Nov-Dec
TI  - Patient experiences of taking antidepressants for depression: a secondary
      qualitative analysis.
PG  - 884-902
LID - 10.1016/j.sapharm.2012.11.002 [doi]
LID - S1551-7411(12)00333-6 [pii]
AB  - BACKGROUND: Depression is one of the most commonly encountered mental health
      problems leading to significant morbidity and mortality and high medical and
      societal costs. Antidepressant prescribing in the UK has more than doubled in the
      last decade. There are a variety of factors that have been shown to affect a
      patient's experience of taking antidepressants The aim of this research was to
      explore patient narratives interviews about depression and its treatment in order
      to improve patient and health professional understanding of what it is like to
      use antidepressants. METHODS: This study involved a supplementary secondary
      qualitative analysis of 80 in-depth narrative interviews from Healthtalkonline.
      Patients' experiences of using medicines for depression were explored in the
      context of their social, occupational and emotional impact, to identify any
      additional issues and to clarify what type of information people want to find
      after being prescribed a medicine. The interviews were conducted by the
      University of Oxford and had received ethical approval and been consented and
      copyrighted for this purpose. Data were analyzed thematically. RESULTS: The most 
      prominent theme was the coexistence of several conflicting issues around the use 
      of medicines and participants were mostly influenced by the reality of their
      experiences, beliefs, attitudes and interaction with health care. Antidepressants
      appear to occupy a central place in many people' lives. Many people described how
      their medicines had helped them and how this served as a reinforcement to
      continue taking them in order to maintain a "normal life." Those who had stopped 
      taking their antidepressants were likely to have experienced adverse reactions
      and had unsatisfactory interactions with health care professionals. A lack of
      information about antidepressants was a major cause of dissatisfaction often
      shaping attitudes to antidepressants'. CONCLUSIONS: People's experiences with
      antidepressant use have a major impact on treatment continuation and hence
      treatment outcomes. Further studies are needed on depressed patients' beliefs
      about their depression and treatment and how they relate to different stages of
      illness, their interactions with health care and their adherence to
      antidepressants.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Anderson, Claire
AU  - Anderson C
AD  - Division for Social Research in Medicines and Health, School of Pharmacy,
      University of Nottingham, Nottingham NG7 2RD, United Kingdom. Electronic address:
      claire.anderson@nottingham.ac.uk.
FAU - Roy, Tapash
AU  - Roy T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121204
PL  - United States
TA  - Res Social Adm Pharm
JT  - Research in social & administrative pharmacy : RSAP
JID - 101231974
RN  - 0 (Antidepressive Agents)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Antidepressive Agents/*therapeutic use
MH  - *Attitude to Health
MH  - Culture
MH  - Depression/*drug therapy
MH  - Female
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Medication Adherence
MH  - Middle Aged
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - Adverse drug effects
OT  - Antidepressants
OT  - Depression
OT  - Medicines adherence
OT  - Patients' experience
OT  - Secondary qualitative analysis
EDAT- 2012/12/12 06:00
MHDA- 2014/09/12 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/08/14 00:00 [received]
PHST- 2012/11/06 00:00 [revised]
PHST- 2012/11/08 00:00 [accepted]
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2014/09/12 06:00 [medline]
AID - S1551-7411(12)00333-6 [pii]
AID - 10.1016/j.sapharm.2012.11.002 [doi]
PST - ppublish
SO  - Res Social Adm Pharm. 2013 Nov-Dec;9(6):884-902. doi:
      10.1016/j.sapharm.2012.11.002. Epub 2012 Dec 4.


PMID- 23219004
OWN - NLM
STAT- MEDLINE
DCOM- 20140411
LR  - 20220309
IS  - 1528-3968 (Electronic)
IS  - 0029-6554 (Linking)
VI  - 61
IP  - 4
DP  - 2013 Jul-Aug
TI  - Black African immigrant community leaders' views on participation in genomics
      research and DNA biobanking.
PG  - 196-204
LID - 10.1016/j.outlook.2012.10.004 [doi]
LID - S0029-6554(12)00294-1 [pii]
AB  - BACKGROUND: The emergence of DNA biobanks and the power they lend to genomics
      research promise substantial advances in disease prevention and treatment.
      Greater participation of racial/ethnic minority populations is necessary to
      assure a future of personalized medicine for all. PURPOSE: The purpose of this
      study was to explore perspectives on genomics research and DNA biobanking among
      black African immigrants, an often overlooked US subpopulation. METHODS: As part 
      of a larger staged study using community-based participatory research (CBPR)
      methods, we conducted four focus groups with 27 leaders in the black African
      immigrant community, exploring perceptions about genomics, barriers, and
      facilitators to participation in DNA biobanks and ethical ways to engage
      communities. FINDINGS/DISCUSSION: Prominent in their views on genomics research
      was the legacy of colonial mistreatment and exploitation by Western researchers
      in their home countries in sub-Saharan Africa. The central dilemma for
      participants was balancing responsibilities to protect their people from harm and
      to find solutions for African generations to come. They insisted that nothing
      short of a transformation of research practice would elicit the full and
      sustained participation of African immigrants in the genomics enterprise.
      CONCLUSION: To better align practice and policy in the field of genomics research
      and DNA biobanking with values expressed by African immigrant leaders, it is
      recommended that the field adopt a CBPR model for research and a benefit-sharing 
      model for policy.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Buseh, Aaron G
AU  - Buseh AG
AD  - University of Wisconsin-Milwaukee, College of Nursing, Milwaukee, WI 53201, USA. 
      aaronbg@uwm.edu
FAU - Underwood, Sandra M
AU  - Underwood SM
FAU - Stevens, Patricia E
AU  - Stevens PE
FAU - Townsend, Leolia
AU  - Townsend L
FAU - Kelber, Sheryl T
AU  - Kelber ST
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121204
PL  - United States
TA  - Nurs Outlook
JT  - Nursing outlook
JID - 0401075
SB  - IM
MH  - Adult
MH  - Africa/ethnology
MH  - *African Americans
MH  - Aged
MH  - Attitude to Health/*ethnology
MH  - *Biological Specimen Banks/ethics
MH  - Community-Based Participatory Research
MH  - *Emigrants and Immigrants
MH  - Female
MH  - Focus Groups
MH  - *Genetic Research/ethics
MH  - Genomics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Midwestern United States
MH  - Patient Selection
MH  - Qualitative Research
OTO - NOTNLM
OT  - Benefit-sharing model
OT  - Black African immigrants
OT  - Community-based participatory research
OT  - DNA biobanking
OT  - Ethics and research
OT  - Genomics
EDAT- 2012/12/12 06:00
MHDA- 2014/04/12 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/08/13 00:00 [received]
PHST- 2012/10/10 00:00 [revised]
PHST- 2012/10/31 00:00 [accepted]
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2014/04/12 06:00 [medline]
AID - S0029-6554(12)00294-1 [pii]
AID - 10.1016/j.outlook.2012.10.004 [doi]
PST - ppublish
SO  - Nurs Outlook. 2013 Jul-Aug;61(4):196-204. doi: 10.1016/j.outlook.2012.10.004.
      Epub 2012 Dec 4.


PMID- 23218926
OWN - NLM
STAT- MEDLINE
DCOM- 20140715
LR  - 20181202
IS  - 1872-8243 (Electronic)
IS  - 1386-5056 (Linking)
VI  - 82
IP  - 12
DP  - 2013 Dec
TI  - Socio-technical issues and challenges in implementing safe patient handovers:
      insights from ethnographic case studies.
PG  - e345-57
LID - 10.1016/j.ijmedinf.2012.11.001 [doi]
LID - S1386-5056(12)00200-6 [pii]
AB  - PURPOSE: Ineffective handovers in patient care, including those where information
      loss occurs between care providers, have been identified as a risk to patient
      safety. Computerization of health information is often offered as a solution to
      improve the quality of care handovers and decrease adverse events related to
      patient safety. The purpose of this paper is to broaden our understanding of
      clinical handover as a patient safety issue, and to identify socio-technical
      issues which may come to bear on the success of computer based handover tools.
      METHODS: Three in depth ethnographic case studies were undertaken. Field notes
      were transcribed and analyzed with the aid of qualitative data analysis software.
      Within case analysis was performed on each case, and subsequently, cross case
      analyses were performed. RESULTS: We identified five types of socio-technical
      issues which must be addressed if electronic handover tools are to succeed. The
      inter-dependencies of these issues are addressed in relation to arenas in which
      health care work takes place. CONCLUSIONS: We suggest that the contextual nature 
      of information, ethical and medico-legal issues arising in relation to
      information handover, and issues related to data standards and system
      interoperability must be addressed if computerized health information systems are
      to achieve improvements in patient safety related to handovers in care.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Balka, Ellen
AU  - Balka E
AD  - School of Communication, Simon Fraser University, Canada; Centre for Clinical
      Epidemiology & Evaluation, Vancouver Coastal Health, Canada. Electronic address: 
      ellenb@sfu.ca.
FAU - Tolar, Marianne
AU  - Tolar M
FAU - Coates, Shannon
AU  - Coates S
FAU - Whitehouse, Sandra
AU  - Whitehouse S
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121206
PL  - Ireland
TA  - Int J Med Inform
JT  - International journal of medical informatics
JID - 9711057
SB  - IM
MH  - *Anthropology, Cultural
MH  - *Continuity of Patient Care
MH  - *Hospital Information Systems
MH  - Humans
MH  - Medical Errors/*prevention & control
MH  - Medical Records Systems, Computerized/statistics & numerical data
MH  - *Patient Safety
MH  - Patient Transfer/*organization & administration
MH  - Safety Management
MH  - Skiing/injuries
MH  - Workflow
OTO - NOTNLM
OT  - Electronic patient records
OT  - Ethnographic field studies
OT  - Ghost charts
OT  - Handovers
OT  - Patient safety
OT  - Socio-technical perspective
EDAT- 2012/12/12 06:00
MHDA- 2014/07/16 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/02/09 00:00 [received]
PHST- 2012/10/17 00:00 [revised]
PHST- 2012/11/01 00:00 [accepted]
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2014/07/16 06:00 [medline]
AID - S1386-5056(12)00200-6 [pii]
AID - 10.1016/j.ijmedinf.2012.11.001 [doi]
PST - ppublish
SO  - Int J Med Inform. 2013 Dec;82(12):e345-57. doi: 10.1016/j.ijmedinf.2012.11.001.
      Epub 2012 Dec 6.


PMID- 23218919
OWN - NLM
STAT- MEDLINE
DCOM- 20151005
LR  - 20140609
IS  - 1036-7314 (Print)
IS  - 1036-7314 (Linking)
VI  - 27
IP  - 2
DP  - 2014 May
TI  - Medical futility in the care of non-competent terminally ill patient: nursing
      perspectives and responsibilities.
PG  - 99-102
LID - 10.1016/j.aucc.2012.10.003 [doi]
LID - S1036-7314(12)00150-6 [pii]
AB  - BACKGROUND: Debate continues on the use of medical technology to prolong life
      independent of the quality of the outcomes. As a consequence, acute care nurses
      often find themselves in situations where they are asked to carry out physician's
      orders, in the context of a patient's deteriorating condition, which may be at
      odds with professional and personal ethical standards. This can cause nurses to
      become distressed when struggling with the ethical dilemmas involved with medical
      futility. PURPOSE: This paper is a perspective on nursing considerations of our
      Code of Ethics and the concept of medical futility in acute nursing care. The
      utility of the Code is examined through a clinical vignette. METHOD: A database
      search using the keywords medical futility and acute care limited to 2008 to 2012
      and a secondary hand search of these references identified thirty journal
      publications. The Code of Ethics was examined via a clinical scenario pertinent
      to an acute environment. FINDINGS: This paper examines the ethical principles
      that underpin nursing and illustrates how the code of ethics may serve as sign
      posts when faced with caring for a terminally ill patient that is inappropriately
      managed. CONCLUSION: Understanding how individual nurses may address ethical
      dilemmas when faced with medical futility can better enable the nurse to fulfil
      their role as patient advocate, health promoter and alleviator of suffering.
      Ongoing education and communication to decrease any ambiguity or anguish
      associated with a patient's impending death optimises apt outcomes.
CI  - Copyright (c) 2012 Australian College of Critical Care Nurses Ltd. All rights
      reserved.
FAU - Scanlon, Andrew
AU  - Scanlon A
AD  - La Trobe University/Austin Health Clinical School of Nursing, Faculty of Health
      Sciences, La Trobe University, Melbourne, Australia; Department of Neurosurgery, 
      Austin Health, Heidelberg, Australia. Electronic address:
      a.scanlon@latrobe.edu.au.
FAU - Murphy, Maria
AU  - Murphy M
AD  - La Trobe University/Austin Health Clinical School of Nursing, Faculty of Health
      Sciences, La Trobe University, Melbourne, Australia.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20121204
PL  - Australia
TA  - Aust Crit Care
JT  - Australian critical care : official journal of the Confederation of Australian
      Critical Care Nurses
JID - 9207852
MH  - Aged
MH  - Critical Care/*ethics/methods
MH  - Decision Making/*ethics
MH  - Ethicists
MH  - Female
MH  - Humans
MH  - Judgment/*ethics
MH  - *Medical Futility
MH  - *Mental Competency
MH  - Nursing Care/*ethics
MH  - *Terminally Ill
OTO - NOTNLM
OT  - Acute care
OT  - Clinical
OT  - Decision making
OT  - Medical futility
OT  - Nurse-patient relations
OT  - Nursing ethics
OT  - Palliative care
EDAT- 2012/12/12 06:00
MHDA- 2015/10/06 06:00
CRDT- 2012/12/11 06:00
PHST- 2011/08/23 00:00 [received]
PHST- 2012/10/22 00:00 [revised]
PHST- 2012/10/25 00:00 [accepted]
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2015/10/06 06:00 [medline]
AID - S1036-7314(12)00150-6 [pii]
AID - 10.1016/j.aucc.2012.10.003 [doi]
PST - ppublish
SO  - Aust Crit Care. 2014 May;27(2):99-102. doi: 10.1016/j.aucc.2012.10.003. Epub 2012
      Dec 4.


PMID- 23218465
OWN - NLM
STAT- MEDLINE
DCOM- 20130723
LR  - 20130524
IS  - 1916-7075 (Electronic)
IS  - 0828-282X (Linking)
VI  - 29
IP  - 6
DP  - 2013 Jun
TI  - Transcatheter aortic valve implantation: recommendations for practice based on a 
      multidisciplinary review including cost-effectiveness and ethical and
      organizational issues.
PG  - 718-26
LID - 10.1016/j.cjca.2012.09.002 [doi]
LID - S0828-282X(12)01304-9 [pii]
AB  - Transcatheter aortic valve implantation (TAVI) is a relatively new technology for
      the treatment of severe and symptomatic aortic valve stenosis. TAVI offers an
      alternative therapy for patients unable to be treated surgically because of
      contraindications or severe comorbidities. It is being rapidly dispersed in
      Canada, as it is worldwide. The objective of this article is to present our
      recommendations for the use of TAVI, based on a multidisciplinary evaluation of
      recently published evidence. We systematically searched and summarized published 
      data (2008-2011) on benefits, risks, and cost-effectiveness of TAVI. We also
      examined ethical issues and organizational aspects of delivering the
      intervention. We discussed the soundness and applicability of our recommendations
      with clinical experts active in the field. The published TAVI results for
      high-risk and/or inoperable patients are promising in terms of survival,
      function, quality of life, and cost-effectiveness, although we noted large
      variability in the survival rates at 1 year and in the frequency of important
      adverse outcomes such as stroke. Until more data from randomized controlled
      trials and registries become available, prudence and discernment are necessary in
      the choice of patients most likely to benefit. Patients need to be well-informed 
      about gaps in the evidence base. Our recommendations support the use of TAVI in
      the context of strict conditions with respect to patient eligibility, the patient
      selection process, organizational requirements, and the tracking of patient
      outcomes with a mandatory registry.
CI  - Copyright (c) 2013 Canadian Cardiovascular Society. Published by Elsevier Inc.
      All rights reserved.
FAU - Boothroyd, Lucy J
AU  - Boothroyd LJ
AD  - Institut national d'excellence en sante et en services sociaux, Montreal, Quebec,
      Canada. lucy.boothroyd@inesss.qc.ca
FAU - Spaziano, Marco
AU  - Spaziano M
FAU - Guertin, Jason R
AU  - Guertin JR
FAU - Lambert, Laurie J
AU  - Lambert LJ
FAU - Rodes-Cabau, Josep
AU  - Rodes-Cabau J
FAU - Noiseux, Nicolas
AU  - Noiseux N
FAU - Nguyen, Michel
AU  - Nguyen M
FAU - Dumont, Eric
AU  - Dumont E
FAU - Carrier, Michel
AU  - Carrier M
FAU - de Varennes, Benoit
AU  - de Varennes B
FAU - Ibrahim, Reda
AU  - Ibrahim R
FAU - Martucci, Giuseppe
AU  - Martucci G
FAU - Xiao, Yongling
AU  - Xiao Y
FAU - Morin, Jean E
AU  - Morin JE
FAU - Bogaty, Peter
AU  - Bogaty P
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20121204
PL  - England
TA  - Can J Cardiol
JT  - The Canadian journal of cardiology
JID - 8510280
SB  - IM
MH  - Aortic Valve Stenosis/*surgery
MH  - *Cardiac Catheterization/economics/ethics/methods
MH  - Cost-Benefit Analysis
MH  - *Heart Valve Prosthesis Implantation/economics/ethics/methods
MH  - Humans
MH  - *Practice Guidelines as Topic
EDAT- 2012/12/12 06:00
MHDA- 2013/07/24 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/07/27 00:00 [received]
PHST- 2012/09/07 00:00 [revised]
PHST- 2012/09/07 00:00 [accepted]
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/07/24 06:00 [medline]
AID - S0828-282X(12)01304-9 [pii]
AID - 10.1016/j.cjca.2012.09.002 [doi]
PST - ppublish
SO  - Can J Cardiol. 2013 Jun;29(6):718-26. doi: 10.1016/j.cjca.2012.09.002. Epub 2012 
      Dec 4.


PMID- 23218439
OWN - NLM
STAT- MEDLINE
DCOM- 20130308
LR  - 20121225
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 77
DP  - 2013 Jan
TI  - Public preferences over efficiency, equity and autonomy in vaccination policy: an
      empirical study.
PG  - 84-9
LID - 10.1016/j.socscimed.2012.11.009 [doi]
LID - S0277-9536(12)00758-7 [pii]
AB  - Vaccination programs increasingly have to comply with standards of evidence-based
      decision making. However, such a framework tends to ignore social and ethical
      sensitivities, risking policy choices that lack crucial public support. Research 
      is needed under which circumstances and to which extent equity and autonomy
      should prevail over effectiveness and cost-effectiveness in matters of infectious
      disease prevention. We report on a study investigating public preferences over
      various vaccination policy options, based on a population survey held in
      Flanders, Belgium (N = 1049) between March and July 2011. We found (1) that
      public support varied considerably between policies that were equally efficient
      in preventing disease but differed according to target group or incentives to
      improve uptake and (2) that preferences over the use of legal compulsion,
      financial accountability or the offering of rewards appear to be driven by
      individuals' social orientation.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Luyten, Jeroen
AU  - Luyten J
AD  - Centre for Health Economics Research and Modeling Infectious Diseases, Vaccine
      and Infectious Disease Institute, University of Antwerp, Universiteitsplein 1,
      2610 Wilrijk, Belgium. Jeroen.luyten@ua.ac.be
FAU - Dorgali, Veronica
AU  - Dorgali V
FAU - Hens, Niel
AU  - Hens N
FAU - Beutels, Philippe
AU  - Beutels P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121116
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Belgium
MH  - Communicable Disease Control/economics/*methods
MH  - Cost-Benefit Analysis
MH  - Empirical Research
MH  - Female
MH  - *Health Policy
MH  - Humans
MH  - Immunization Programs/*methods
MH  - Male
MH  - Middle Aged
MH  - Personal Autonomy
MH  - Program Evaluation
MH  - *Public Opinion
MH  - Social Justice
MH  - Young Adult
EDAT- 2012/12/12 06:00
MHDA- 2013/03/09 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/03/30 00:00 [received]
PHST- 2012/10/25 00:00 [revised]
PHST- 2012/11/07 00:00 [accepted]
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/03/09 06:00 [medline]
AID - S0277-9536(12)00758-7 [pii]
AID - 10.1016/j.socscimed.2012.11.009 [doi]
PST - ppublish
SO  - Soc Sci Med. 2013 Jan;77:84-9. doi: 10.1016/j.socscimed.2012.11.009. Epub 2012
      Nov 16.


PMID- 23218060
OWN - NLM
STAT- MEDLINE
DCOM- 20140114
LR  - 20130304
IS  - 1545-7206 (Electronic)
IS  - 0033-3182 (Linking)
VI  - 54
IP  - 2
DP  - 2013 Mar-Apr
TI  - Beyond capacity: identifying ethical dilemmas underlying capacity evaluation
      requests.
PG  - 103-10
LID - 10.1016/j.psym.2012.06.003 [doi]
LID - S0033-3182(12)00111-9 [pii]
AB  - BACKGROUND: Psychiatric consultations involving the evaluation of patients'
      medical decision-making capacity often seem to have little to do with truly
      compromised patient autonomy. OBJECTIVE: The authors seek to examine hidden
      ethical dilemmas that lead to capacity evaluation requests. METHOD: The authors
      utilize the "principlism" approach to biomedical ethics to illustrate some common
      moral issues in patient care that are poorly captured by the
      "autonomy-versus-paternalism" paradigm. RESULTS: Patient autonomy sometimes comes
      into conflict with ethical imperatives to do "good," to avoid harm, and to
      deliver care fairly, as well as with the autonomy of others. Consultation
      psychiatrists are well positioned to unearth these dilemmas and begin to address 
      them. DISCUSSION: Effective engagement of everyday ethics in clinical medicine is
      hindered by reflexive resort to capacity evaluations when moral problems arise.
      Greater attention to matters of values, aggressive urges, and obligations to
      others can enhance the negotiation of routine ethical dilemmas.
CI  - Copyright (c) 2013 The Academy of Psychosomatic Medicine. Published by Elsevier
      Inc. All rights reserved.
FAU - Kontos, Nicholas
AU  - Kontos N
AD  - Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA. 
      nkontos@partners.org
FAU - Freudenreich, Oliver
AU  - Freudenreich O
FAU - Querques, John
AU  - Querques J
LA  - eng
PT  - Journal Article
DEP - 20121204
PL  - England
TA  - Psychosomatics
JT  - Psychosomatics
JID - 0376506
SB  - IM
CIN - Psychosomatics. 2013 Sep-Oct;54(5):502-3. PMID: 23845317
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Bioethics
MH  - Decision Making/*ethics
MH  - Female
MH  - Humans
MH  - Informed Consent/*ethics/psychology
MH  - Male
MH  - Mental Competency/*psychology
MH  - Paternalism/ethics
MH  - Patient Rights/ethics
MH  - *Personal Autonomy
MH  - Principle-Based Ethics
MH  - Referral and Consultation
EDAT- 2012/12/12 06:00
MHDA- 2014/01/15 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/03/12 00:00 [received]
PHST- 2012/06/04 00:00 [revised]
PHST- 2012/06/06 00:00 [accepted]
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2014/01/15 06:00 [medline]
AID - S0033-3182(12)00111-9 [pii]
AID - 10.1016/j.psym.2012.06.003 [doi]
PST - ppublish
SO  - Psychosomatics. 2013 Mar-Apr;54(2):103-10. doi: 10.1016/j.psym.2012.06.003. Epub 
      2012 Dec 4.


PMID- 23217476
OWN - NLM
STAT- MEDLINE
DCOM- 20130425
LR  - 20130828
IS  - 1681-7168 (Electronic)
IS  - 1022-386X (Linking)
VI  - 22
IP  - 12
DP  - 2012 Dec
TI  - End of life care in Pakistan; some ethical issues.
PG  - 745-6
LID - 12.2012/JCPSP.745746 [doi]
FAU - Khan, Robyna Irshad
AU  - Khan RI
LA  - eng
PT  - Editorial
PL  - Pakistan
TA  - J Coll Physicians Surg Pak
JT  - Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
JID - 9606447
SB  - IM
CIN - J Coll Physicians Surg Pak. 2013 Jul;23(7):527. PMID: 23823967
MH  - Culture
MH  - Humans
MH  - Life Support Care/*ethics
MH  - Pakistan
MH  - Palliative Care/*ethics
MH  - Professional-Family Relations
MH  - Professional-Patient Relations
MH  - Terminal Care/*ethics
EDAT- 2012/12/12 06:00
MHDA- 2013/04/26 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/09/20 00:00 [received]
PHST- 2012/08/31 00:00 [accepted]
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/04/26 06:00 [medline]
AID - 040579197 [pii]
AID - 12.2012/JCPSP.745746 [doi]
PST - ppublish
SO  - J Coll Physicians Surg Pak. 2012 Dec;22(12):745-6. doi: 12.2012/JCPSP.745746.


PMID- 23217444
OWN - NLM
STAT- MEDLINE
DCOM- 20131118
LR  - 20181202
IS  - 1486-3847 (Print)
IS  - 1486-3847 (Linking)
VI  - 73
IP  - 4
DP  - 2012 Winter
TI  - Videoconferencing and dietitian services in rural Ontario communities.
PG  - 176-80
AB  - Registered dietitians (RDs) are regulated health professionals in short supply in
      Ontario and throughout Canada. Projected workforce studies indicate the situation
      will likely worsen. Accessing these nutrition specialists is an even greater
      concern for residents living in rural or remote regions of the province. Smaller 
      communities are increasingly using telehealth as a way to deliver health care
      services and to improve access to health care professionals. The adoption of
      interactive videoconferencing as a telehealth application is examined as an
      alternative approach for accessing RDs in rural communities. While valid reasons 
      exist for implementing videoconferencing, other issues must be considered. These 
      include costs, technological requirements, organizational readiness, and legal
      and ethical concerns. Future research must fully address the concept of
      videoconferencing in relation to the Canadian dietetic workforce and practice
      requirements.
FAU - Stenlund, Diana
AU  - Stenlund D
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can J Diet Pract Res
JT  - Canadian journal of dietetic practice and research : a publication of Dietitians 
      of Canada = Revue canadienne de la pratique et de la recherche en dietetique :
      une publication des Dietetistes du Canada
JID - 9811151
SB  - IM
MH  - Dietetics/economics/*methods
MH  - Health Resources/economics
MH  - Humans
MH  - Ontario
MH  - *Rural Health Services/economics
MH  - *Telemedicine/economics
MH  - *Videoconferencing
MH  - Workforce
EDAT- 2012/12/12 06:00
MHDA- 2013/11/19 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/11/19 06:00 [medline]
AID - 10.3148/73.4.2012.176 [doi]
PST - ppublish
SO  - Can J Diet Pract Res. 2012 Winter;73(4):176-80. doi: 10.3148/73.4.2012.176.


PMID- 23217435
OWN - NLM
STAT- MEDLINE
DCOM- 20130205
LR  - 20130502
IS  - 1873-1740 (Electronic)
IS  - 0033-0620 (Linking)
VI  - 55
IP  - 3
DP  - 2012 Nov-Dec
TI  - Ethics considerations for medical device R&D.
PG  - 307-15
LID - 10.1016/j.pcad.2012.08.004 [doi]
LID - S0033-0620(12)00153-3 [pii]
AB  - Medical devices have emerged as an important clinical option to treat certain
      serious diseases for which there are no equivalently effective surgical or
      pharmaceutical alternatives. Although all clinical activities impose high ethical
      standards of comportment to protect patients, medical device R&D and product
      application have a number of relatively unique aspects that distinguish them from
      other technologies such as pharmaceuticals. These include the following: R&D
      project selection; regulatory requirements, and their intended and unintended
      effects; when is a new product design sufficiently safe and effective for routine
      use in patients; and, physician-industry relationships in the innovation process 
      in the context of real or perceived conflict of interest (COI). Each of these
      factors has implications for the delivery of care, health care leadership, and
      patient well-being.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Citron, Paul
AU  - Citron P
AD  - paulcitron@msn.com
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Prog Cardiovasc Dis
JT  - Progress in cardiovascular diseases
JID - 0376442
SB  - IM
MH  - *Conflict of Interest
MH  - Equipment and Supplies/*standards
MH  - Humans
MH  - Physicians/*ethics
MH  - Product Surveillance, Postmarketing/*methods
MH  - United States
MH  - United States Food and Drug Administration
EDAT- 2012/12/12 06:00
MHDA- 2013/02/06 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/02/06 06:00 [medline]
AID - S0033-0620(12)00153-3 [pii]
AID - 10.1016/j.pcad.2012.08.004 [doi]
PST - ppublish
SO  - Prog Cardiovasc Dis. 2012 Nov-Dec;55(3):307-15. doi: 10.1016/j.pcad.2012.08.004.


PMID- 23217433
OWN - NLM
STAT- MEDLINE
DCOM- 20130205
LR  - 20211021
IS  - 1873-1740 (Electronic)
IS  - 0033-0620 (Linking)
VI  - 55
IP  - 3
DP  - 2012 Nov-Dec
TI  - Deactivation of pacemakers and implantable cardioverter-defibrillators.
PG  - 290-9
LID - 10.1016/j.pcad.2012.09.003 [doi]
LID - S0033-0620(12)00176-4 [pii]
AB  - Cardiac implantable electrical devices (CIEDs), including pacemakers (PMs) and
      implantable cardioverter-defibrillators (ICDs), are the most effective treatment 
      for life-threatening arrhythmias. Patients or their surrogates may request device
      deactivation to avoid prolongation of the dying process or in other settings,
      such as after device-related complications or with changes in health care goals. 
      Despite published guidelines outlining theoretical and practical aspects of this 
      common clinical scenario, significant uncertainty remains for both patients and
      health care providers regarding the ethical and legal status of CIED
      deactivation. This review outlines the ethical and legal principles supporting
      CIED deactivation, centered upon patient autonomy and authority over their own
      medical treatment. The empirical literature describing stakeholder views and
      experiences surrounding CIED deactivation is described, along with implications
      of these studies for future research surrounding the care of patients with CIEDs.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Kramer, Daniel B
AU  - Kramer DB
AD  - Hebrew SeniorLife Institute for Aging Research, Boston, MA, USA.
      danielkramer@hsl.harvard.edu
FAU - Mitchell, Susan L
AU  - Mitchell SL
FAU - Brock, Dan W
AU  - Brock DW
LA  - eng
GR  - K24 AG033640/AG/NIA NIH HHS/United States
GR  - KL2 TR000168/TR/NCATS NIH HHS/United States
GR  - K24AG033640/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Prog Cardiovasc Dis
JT  - Progress in cardiovascular diseases
JID - 0376442
SB  - IM
MH  - Arrhythmias, Cardiac/*therapy
MH  - Defibrillators, Implantable/*ethics
MH  - Health Personnel/*ethics
MH  - Humans
MH  - Pacemaker, Artificial/*ethics
MH  - Terminal Care/ethics/*legislation & jurisprudence
MH  - Withholding Treatment/ethics/*legislation & jurisprudence
PMC - PMC3583554
MID - NIHMS422402
EDAT- 2012/12/12 06:00
MHDA- 2013/02/06 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/02/06 06:00 [medline]
AID - S0033-0620(12)00176-4 [pii]
AID - 10.1016/j.pcad.2012.09.003 [doi]
PST - ppublish
SO  - Prog Cardiovasc Dis. 2012 Nov-Dec;55(3):290-9. doi: 10.1016/j.pcad.2012.09.003.


PMID- 23217432
OWN - NLM
STAT- MEDLINE
DCOM- 20130205
LR  - 20130502
IS  - 1873-1740 (Electronic)
IS  - 0033-0620 (Linking)
VI  - 55
IP  - 3
DP  - 2012 Nov-Dec
TI  - Ethical issues in organ transplantation.
PG  - 282-9
LID - 10.1016/j.pcad.2012.08.005 [doi]
LID - S0033-0620(12)00154-5 [pii]
AB  - We discuss ethical issues of organ transplantation including the stewardship
      tension between physicians' duty to do everything possible for their patients and
      their duty to serve society by encouraging organ donation. We emphasize
      consideration of the role of the principles of justice, utility and equity in the
      just distribution of transplantable organ as scarce resources. We then consider
      ethical issues of determining death of the organ donor including the remaining
      controversies in brain death determination and the new controversies raised by
      circulatory death determination. We need uniformity in standards of death
      determination, agreement on the duration of asystole before death is declared,
      and consensus on the allowable circulatory interventions on the newly declared
      organ donor that are intended to improve organ function. We discuss the
      importance of maintaining the dead donor rule, despite the argument of some
      scholars to abandon it.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Freeman, Richard B
AU  - Freeman RB
AD  - Department of Surgery, Geisel School of Medicine at Dartmouth,
      Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA.
      richard.b.freeman@dartmouth.edu
FAU - Bernat, James L
AU  - Bernat JL
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Prog Cardiovasc Dis
JT  - Progress in cardiovascular diseases
JID - 0376442
SB  - IM
MH  - *Ethics, Medical
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Tissue Donors/*ethics
MH  - Tissue and Organ Procurement/*ethics
EDAT- 2012/12/12 06:00
MHDA- 2013/02/06 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/02/06 06:00 [medline]
AID - S0033-0620(12)00154-5 [pii]
AID - 10.1016/j.pcad.2012.08.005 [doi]
PST - ppublish
SO  - Prog Cardiovasc Dis. 2012 Nov-Dec;55(3):282-9. doi: 10.1016/j.pcad.2012.08.005.


PMID- 23217430
OWN - NLM
STAT- MEDLINE
DCOM- 20130205
LR  - 20130502
IS  - 1873-1740 (Electronic)
IS  - 0033-0620 (Linking)
VI  - 55
IP  - 3
DP  - 2012 Nov-Dec
TI  - Ethics priorities in adult congenital heart disease.
PG  - 266-273.e3
LID - 10.1016/j.pcad.2012.10.004 [doi]
LID - S0033-0620(12)00181-8 [pii]
AB  - The success of modern therapies in congenital heart disease has produced a large 
      and growing population of adults with congenital heart disease as a chronic
      condition. Such success increasingly raises a host of ethical issues, from
      resource utilization to end of life decision-making. The importance of a
      multidisciplinary approach to the care of adult congenital heart disease (ACHD)
      patients has been emphasized for some time, but addressing the challenges in this
      population requires a broad range of ethical expertise as well. This paper is
      based on a conference entitled "Ethical and Policy Challenges in Pediatric and
      Adult Congenital Heart Disease" held in March of 2012. Herein, we present a
      compilation of the ethics priorities in ACHD discussed at the conference,
      including ethical aspects of clinical care, ethics research and policy
      development in the areas of providing clinical care for challenging ACHD
      patients, improving transitions from pediatric to adult healthcare systems,
      advance care planning, and addressing costs.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Kirkpatrick, James N
AU  - Kirkpatrick JN
AD  - Cardiovascular Medicine Division, University of Pennsylvania, Philadelphia, PA
      19104, USA. James.kirkpatrick@uphs.upenn.edu
FAU - Kim, Yuli Y
AU  - Kim YY
FAU - Kaufman, Beth D
AU  - Kaufman BD
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Prog Cardiovasc Dis
JT  - Progress in cardiovascular diseases
JID - 0376442
SB  - IM
MH  - Adult
MH  - *Ethics, Medical
MH  - Heart Defects, Congenital/*therapy
MH  - Humans
MH  - Patient Care Team/*ethics
MH  - *Policy Making
EDAT- 2012/12/12 06:00
MHDA- 2013/02/06 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/02/06 06:00 [medline]
AID - S0033-0620(12)00181-8 [pii]
AID - 10.1016/j.pcad.2012.10.004 [doi]
PST - ppublish
SO  - Prog Cardiovasc Dis. 2012 Nov-Dec;55(3):266-273.e3. doi:
      10.1016/j.pcad.2012.10.004.


PMID- 23217427
OWN - NLM
STAT- MEDLINE
DCOM- 20130205
LR  - 20150813
IS  - 1873-1740 (Electronic)
IS  - 0033-0620 (Linking)
VI  - 55
IP  - 3
DP  - 2012 Nov-Dec
TI  - The enduring legacy of sham-controlled trials of internal mammary artery
      ligation.
PG  - 246-50
LID - 10.1016/j.pcad.2012.09.002 [doi]
LID - S0033-0620(12)00171-5 [pii]
AB  - In 1959 and 1960 the results of two randomized controlled trials demonstrated
      that bilateral internal mammary artery ligation was no better than a sham
      intervention in the treatment of angina. These landmark trials were the first to 
      use blinded placebo controls to evaluate invasive procedures. Revisiting the
      story of internal mammary artery ligation offers valuable insights into the
      ethics of sham-controlled trials and the implications of the placebo effect for
      thinking about risk-benefit assessment of sham procedures.
CI  - Published by Elsevier Inc.
FAU - Miller, Franklin G
AU  - Miller FG
AD  - Department of Bioethics, Clinical Center, National Institutes of Health,
      Bethesda, MD 20892-1156, USA. fmiller@nih.gov
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Review
PL  - United States
TA  - Prog Cardiovasc Dis
JT  - Progress in cardiovascular diseases
JID - 0376442
SB  - IM
MH  - Angina Pectoris/*surgery
MH  - *Controlled Clinical Trials as Topic
MH  - Coronary Artery Bypass/*methods
MH  - Humans
MH  - Ligation
MH  - Mammary Arteries/*surgery
EDAT- 2012/12/12 06:00
MHDA- 2013/02/06 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/02/06 06:00 [medline]
AID - S0033-0620(12)00171-5 [pii]
AID - 10.1016/j.pcad.2012.09.002 [doi]
PST - ppublish
SO  - Prog Cardiovasc Dis. 2012 Nov-Dec;55(3):246-50. doi: 10.1016/j.pcad.2012.09.002.


PMID- 23217422
OWN - NLM
STAT- MEDLINE
DCOM- 20130730
LR  - 20211203
IS  - 1875-9777 (Electronic)
IS  - 1875-9777 (Linking)
VI  - 11
IP  - 6
DP  - 2012 Dec 7
TI  - Ethical and policy issues in the clinical translation of stem cells: report of a 
      focus session at the ISSCR Tenth Annual Meeting.
PG  - 765-7
LID - 10.1016/j.stem.2012.11.004 [doi]
LID - S1934-5909(12)00638-8 [pii]
AB  - Alongside the scientific barriers to the clinical translation of stem cell
      research are ethical and regulatory hurdles. Some of these challenges described
      by the Ethics and Public Policy Committee at the ISSCR Tenth Annual Meeting are
      presented here.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Kato, Kazuto
AU  - Kato K
AD  - Department of Biomedical Ethics and Public Policy, Graduate School of Medicine,
      Osaka University, 2-2 Yamadaoka, Suita 565-0871, Japan.
      katok@eth.med.osaka-u.ac.jp
FAU - Kimmelman, Jonathan
AU  - Kimmelman J
FAU - Robert, Jason
AU  - Robert J
FAU - Sipp, Douglas
AU  - Sipp D
FAU - Sugarman, Jeremy
AU  - Sugarman J
LA  - eng
PT  - Congress
PL  - United States
TA  - Cell Stem Cell
JT  - Cell stem cell
JID - 101311472
SB  - IM
MH  - Clinical Trials as Topic/ethics
MH  - Communication Barriers
MH  - Humans
MH  - *Policy Making
MH  - Stem Cell Research/*ethics
MH  - Translational Research, Biomedical/*ethics
EDAT- 2012/12/12 06:00
MHDA- 2013/07/31 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/07/31 06:00 [medline]
AID - S1934-5909(12)00638-8 [pii]
AID - 10.1016/j.stem.2012.11.004 [doi]
PST - ppublish
SO  - Cell Stem Cell. 2012 Dec 7;11(6):765-7. doi: 10.1016/j.stem.2012.11.004.


PMID- 23217117
OWN - NLM
STAT- MEDLINE
DCOM- 20130321
LR  - 20130123
IS  - 1365-3156 (Electronic)
IS  - 1360-2276 (Linking)
VI  - 18
IP  - 2
DP  - 2013 Feb
TI  - Challenges of non-commercial multicentre North-South collaborative clinical
      trials.
PG  - 237-41
LID - 10.1111/tmi.12036 [doi]
AB  - The last decade has witnessed a substantial increase of multi-centre, public
      health-oriented clinical trials in poor countries. However, non-commercial
      research groups have less staff and financial resources than traditional
      commercial sponsors, so the trial teams have to be creative to comply with Good
      Clinical Practices (GCP) requirements. According to the recent experience of a
      large multicentre trial on antimalarials, major challenges result from the
      complexity of multiple ethical review, the costs of in-depth monitoring at
      several sites, setting up an adequate Good Clinical Laboratory Practices (GCLP)
      framework, lack of insurers in host countries, and lack of adequate
      non-commercial data management software. Public research funding agencies need to
      consider these challenges in their funding policies. They also could support
      common spaces where North-South collaborative research groups may share critical 
      information, such as on research insurance and open-source, GCP-compliant
      software. WHO should update its GCP guidelines, which date back to 1995, to
      incorporate the perspectives and needs of non-commercial clinical research.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Ravinetto, Raffaella M
AU  - Ravinetto RM
FAU - Talisuna, Ambrose
AU  - Talisuna A
FAU - De Crop, Maaike
AU  - De Crop M
FAU - van Loen, Harry
AU  - van Loen H
FAU - Menten, Joris
AU  - Menten J
FAU - Van Overmeir, Chantal
AU  - Van Overmeir C
FAU - Tinto, Halidou
AU  - Tinto H
FAU - Gonzalez, Raquel
AU  - Gonzalez R
FAU - Meremikwu, Martin
AU  - Meremikwu M
FAU - Nabasuma, Carolyn
AU  - Nabasuma C
FAU - Ngoma, Ghyslain M
AU  - Ngoma GM
FAU - Karema, Corine
AU  - Karema C
FAU - Adoke, Yeka
AU  - Adoke Y
FAU - Chaponda, Mike
AU  - Chaponda M
FAU - Van Geertruyden, Jean-Pierre
AU  - Van Geertruyden JP
FAU - D'Alessandro, Umberto
AU  - D'Alessandro U
LA  - eng
PT  - Editorial
PT  - Research Support, Non-U.S. Gov't
DEP - 20121210
PL  - England
TA  - Trop Med Int Health
JT  - Tropical medicine & international health : TM & IH
JID - 9610576
SB  - IM
MH  - Biomedical Research/methods/*standards
MH  - Clinical Laboratory Techniques/*standards
MH  - Clinical Trials as Topic
MH  - Cooperative Behavior
MH  - Humans
MH  - International Cooperation
MH  - Practice Guidelines as Topic/*standards
MH  - World Health Organization
EDAT- 2012/12/12 06:00
MHDA- 2013/03/22 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/03/22 06:00 [medline]
AID - 10.1111/tmi.12036 [doi]
PST - ppublish
SO  - Trop Med Int Health. 2013 Feb;18(2):237-41. doi: 10.1111/tmi.12036. Epub 2012 Dec
      10.


PMID- 23216985
OWN - NLM
STAT- MEDLINE
DCOM- 20130822
LR  - 20211021
IS  - 1471-2407 (Electronic)
IS  - 1471-2407 (Linking)
VI  - 12
DP  - 2012 Dec 5
TI  - Breast ductal lavage for biomarker assessment in high risk women: rationale,
      design and methodology of a randomized phase II clinical trial with nimesulide,
      simvastatin and placebo.
PG  - 575
LID - 10.1186/1471-2407-12-575 [doi]
AB  - BACKGROUND: Despite positive results from large phase III clinical trials proved 
      that it is possible to prevent estrogen-responsive breast cancers with selective 
      estrogen receptor modulators and aromatase inhibitors, no significant results
      have been reached so far to prevent hormone non-responsive tumors. The Ductal
      Lavage (DL) procedure offers a minimally invasive method to obtain breast
      epithelial cells from the ductal system for cytopathologic analysis. Several
      studies with long-term follow-up have shown that women with atypical hyperplasia 
      have an elevated risk of developing breast cancer. The objective of the proposed 
      trial is to assess the efficacy and safety of a daily administration of
      nimesulide or simvastatin in women at higher risk for breast cancer, focused
      particularly on hormone non-responsive tumor risk. The primary endpoint is the
      change in prevalence of atypical cells and cell proliferation (measured by Ki67) 
      in DL or fine needle aspirate samples, after 12 months of treatment and 12 months
      after treatment cessation. METHODS-DESIGN: From 2005 to 2011, 150 women with a
      history of estrogen receptor negative ductal intraepithelial neoplasia or lobular
      intraepithelial neoplasia or atypical hyperplasia, or unaffected subjects
      carrying a mutation of BRCA1 or with a probability of mutation >10% (according to
      BRCAPRO) were randomized to receive nimesulide 100mg/day versus simvastatin
      20mg/day versus placebo for one year followed by a second year of follow-up.
      DISCUSSION: This is the first randomized placebo controlled trial to evaluate the
      role of DL to study surrogate endpoints biomarkers and the effects of these drugs
      on breast carcinogenesis. In 2007 the European Medicines Agency limited the use
      of systemic formulations of nimesulide to 15 days. According to the European
      Institute of Oncology Ethics Committee communication, we are now performing an
      even more careful monitoring of the study participants. Preliminary results
      showed that DL is a feasible procedure, the treatment is well tolerated and the
      safety blood tests do not show any significant liver toxicity. There is an urgent
      need to confirm in the clinical setting the potential efficacy of other compounds
      in contrasting hormone non-responsive breast cancer. This paper is focused on the
      methodology and operational aspects of the clinical trial. TRIAL REGISTRATION:
      (ClinicalTrials.gov Identifier: NCT01500577).
FAU - Lazzeroni, Matteo
AU  - Lazzeroni M
AD  - Division of Cancer Prevention and Genetics, European Institute of Oncology,
      Milan, Italy. matteo.lazzeroni@ieo.it
FAU - Guerrieri-Gonzaga, Aliana
AU  - Guerrieri-Gonzaga A
FAU - Serrano, Davide
AU  - Serrano D
FAU - Cazzaniga, Massimiliano
AU  - Cazzaniga M
FAU - Mora, Serena
AU  - Mora S
FAU - Casadio, Chiara
AU  - Casadio C
FAU - Jemos, Costantino
AU  - Jemos C
FAU - Pizzamiglio, Maria
AU  - Pizzamiglio M
FAU - Cortesi, Laura
AU  - Cortesi L
FAU - Radice, Davide
AU  - Radice D
FAU - Bonanni, Bernardo
AU  - Bonanni B
LA  - eng
SI  - ClinicalTrials.gov/NCT01500577
PT  - Clinical Trial, Phase III
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20121205
PL  - England
TA  - BMC Cancer
JT  - BMC cancer
JID - 100967800
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Sulfonamides)
RN  - AGG2FN16EV (Simvastatin)
RN  - V4TKW1454M (nimesulide)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/metabolism
MH  - Breast Neoplasms/metabolism/pathology/*prevention & control
MH  - Cell Proliferation/drug effects
MH  - Double-Blind Method
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Middle Aged
MH  - Risk Factors
MH  - Simvastatin/*administration & dosage/adverse effects
MH  - Sulfonamides/*administration & dosage/adverse effects
MH  - Therapeutic Irrigation/methods
MH  - Young Adult
PMC - PMC3522001
EDAT- 2012/12/12 06:00
MHDA- 2013/08/24 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/10/31 00:00 [received]
PHST- 2012/11/29 00:00 [accepted]
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/08/24 06:00 [medline]
AID - 1471-2407-12-575 [pii]
AID - 10.1186/1471-2407-12-575 [doi]
PST - epublish
SO  - BMC Cancer. 2012 Dec 5;12:575. doi: 10.1186/1471-2407-12-575.


PMID- 23216866
OWN - NLM
STAT- MEDLINE
DCOM- 20130524
LR  - 20211021
IS  - 1472-6947 (Electronic)
IS  - 1472-6947 (Linking)
VI  - 12
DP  - 2012 Dec 5
TI  - Intention to adopt clinical decision support systems in a developing country:
      effect of physician's perceived professional autonomy, involvement and belief: a 
      cross-sectional study.
PG  - 142
LID - 10.1186/1472-6947-12-142 [doi]
AB  - BACKGROUND: Computer-based clinical decision support systems (CDSS) are regarded 
      as a key element to enhance decision-making in a healthcare environment to
      improve the quality of medical care delivery. The concern of having new CDSS
      unused is still one of the biggest issues in developing countries for the
      developers and implementers of clinical IT systems. The main objectives of this
      study are to determine whether (1) the physician's perceived professional
      autonomy, (2) involvement in the decision to implement CDSS and (3) the belief
      that CDSS will improve job performance increase the intention to adopt CDSS. Four
      hypotheses were formulated and tested. METHODS: A questionnaire-based survey
      conducted between July 2010 and December 2010. The study was conducted in seven
      public and five private hospitals in Kuala Lumpur, Malaysia. Before contacting
      the hospitals, necessary permission was obtained from the Ministry of Health,
      Malaysia and the questionnaire was vetted by the ethics committee of the
      ministry. Physicians working in 12 hospitals from 10 different specialties
      participated in the study. The sampling method used was stratified random
      sampling and the physicians were stratified based on the specialty. A total of
      450 physicians were selected using a random number generator. Each of these
      physicians was given a questionnaire and out of 450 questionnaires, 335 (response
      rate--74%) were returned and 309 (69%) were deemed usable. RESULTS: The
      hypotheses were tested using Structural Equation Modeling (SEM). Salient results 
      are: (1) Physicians' perceived threat to professional autonomy lowers the
      intention to use CDSS (p < 0.01); (2) Physicians involvement in the planning,
      design and implementation increases their intention to use CDSS (p < 0.01); (3)
      Physicians belief that the new CDSS will improve his/her job performance
      increases their intention to use CDSS (p < 0.01). CONCLUSION: The proposed model 
      with the three main constructs (physician's professional characteristic,
      involvement and belief) explains 47% of the variance in the intention to use
      CDSS. This is significantly higher than the models addressed so far. The results 
      will have a major impact in implementing CDSS in developing countries.
FAU - Sambasivan, Murali
AU  - Sambasivan M
AD  - Global Entrepreneurship Research and Innovation Center (GERIC), Universiti
      Malaysia Kelantan, Kelantan, Malaysia. sambasivan@hotmail.com
FAU - Esmaeilzadeh, Pouyan
AU  - Esmaeilzadeh P
FAU - Kumar, Naresh
AU  - Kumar N
FAU - Nezakati, Hossein
AU  - Nezakati H
LA  - eng
PT  - Journal Article
DEP - 20121205
PL  - England
TA  - BMC Med Inform Decis Mak
JT  - BMC medical informatics and decision making
JID - 101088682
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Attitude to Computers
MH  - Cross-Sectional Studies
MH  - *Decision Support Systems, Clinical
MH  - Diffusion of Innovation
MH  - Female
MH  - Humans
MH  - *Intention
MH  - Malaysia
MH  - Male
MH  - Medical Staff, Hospital/*psychology
MH  - Middle Aged
MH  - *Professional Autonomy
MH  - Surveys and Questionnaires
MH  - Young Adult
PMC - PMC3519751
EDAT- 2012/12/12 06:00
MHDA- 2013/05/28 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/06/18 00:00 [received]
PHST- 2012/11/27 00:00 [accepted]
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/05/28 06:00 [medline]
AID - 1472-6947-12-142 [pii]
AID - 10.1186/1472-6947-12-142 [doi]
PST - epublish
SO  - BMC Med Inform Decis Mak. 2012 Dec 5;12:142. doi: 10.1186/1472-6947-12-142.


PMID- 23216847
OWN - NLM
STAT- MEDLINE
DCOM- 20130227
LR  - 20211021
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 13
DP  - 2012 Dec 5
TI  - Recruiting terminally ill patients into non-therapeutic oncology studies: views
      of health professionals.
PG  - 33
LID - 10.1186/1472-6939-13-33 [doi]
AB  - BACKGROUND: Non-therapeutic trials in which terminally ill cancer patients are
      asked to undergo procedures such as biopsies or venipunctures for research
      purposes, have become increasingly important to learn more about how cancer cells
      work and to realize the full potential of clinical research. Considering that
      implementing non-therapeutic studies is not likely to result in direct benefits
      for the patient, some authors are concerned that involving patients in such
      research may be exploitive of vulnerable patients and should not occur at all, or
      should be greatly restricted, while some proponents doubt whether such
      restrictions are appropriate. Our objective was to explore clinician-researcher
      attitudes and concerns when recruiting patients who are in advanced stages of
      cancer into non-therapeutic research. METHODS: We conducted a qualitative
      exploratory study by carrying out open-ended interviews with health
      professionals, including physicians, research nurses, and study coordinators.
      Interviews were audio-recorded and transcribed. Analysis was carried out using
      grounded theory. RESULTS: The analysis of the interviews unveiled three prominent
      themes: 1) ethical considerations; 2) patient-centered issues; 3) health
      professional issues. Respondents identified ethical issues surrounding autonomy, 
      respect for persons, beneficence, non-maleficence, discrimination, and
      confidentiality; bringing to light that patients contribute to science because of
      a sense of altruism and that they want reassurance before consenting. Several
      patient-centered and health professional issues are having an impact on the
      recruitment of patients for non-therapeutic research. Facilitators were most
      commonly associated with patient-centered issues enhancing communication, whereas
      barriers in non-therapeutic research were most often professionally based,
      including the doctor-patient relationship, time constraints, and a lack of
      education and training in research. CONCLUSIONS: This paper aims to contribute to
      debates on the overall challenges of recruiting patients to non-therapeutic
      research. This exploratory study identified general awareness of key ethical
      issues, as well as key facilitators and barriers to the recruitment of patients
      to non-therapeutic studies. Due to the important role played by clinicians and
      clinician-researchers in the recruitment of patients, it is essential to
      facilitate a greater understanding of the challenges faced; to promote effective 
      communication; and to encourage educational research training programs.
FAU - Kleiderman, Erika
AU  - Kleiderman E
AD  - Centre of Genomics and Policy, Faculty of Medicine, Dept of Human Genetics,
      McGill University, 740 Dr, Penfield Avenue, 5th Floor, Suite 5200, Montreal, (QC)
      H3A 1A4, Canada. erika.kleiderman@mail.mcgill.ca
FAU - Avard, Denise
AU  - Avard D
FAU - Black, Lee
AU  - Black L
FAU - Diaz, Zuanel
AU  - Diaz Z
FAU - Rousseau, Caroline
AU  - Rousseau C
FAU - Knoppers, Bartha Maria
AU  - Knoppers BM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121205
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Altruism
MH  - Attitude of Health Personnel
MH  - Beneficence
MH  - Confidentiality
MH  - Ethics Committees, Research
MH  - Family
MH  - Humans
MH  - Information Dissemination
MH  - Informed Consent
MH  - Medical Oncology/*ethics/methods/trends
MH  - *Neoplasms/metabolism/pathology
MH  - Nontherapeutic Human Experimentation/*ethics
MH  - Patient Selection/*ethics
MH  - Personal Autonomy
MH  - Physician-Patient Relations/*ethics
MH  - Qualitative Research
MH  - Researcher-Subject Relations/*ethics
MH  - Social Justice
MH  - Social Support
MH  - *Terminally Ill
PMC - PMC3529687
EDAT- 2012/12/12 06:00
MHDA- 2013/02/28 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/07/17 00:00 [received]
PHST- 2012/11/29 00:00 [accepted]
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/02/28 06:00 [medline]
AID - 1472-6939-13-33 [pii]
AID - 10.1186/1472-6939-13-33 [doi]
PST - epublish
SO  - BMC Med Ethics. 2012 Dec 5;13:33. doi: 10.1186/1472-6939-13-33.


PMID- 23216740
OWN - NLM
STAT- MEDLINE
DCOM- 20130627
LR  - 20130102
IS  - 1553-2712 (Electronic)
IS  - 1069-6563 (Linking)
VI  - 19
IP  - 12
DP  - 2012 Dec
TI  - Ethical considerations in education research in emergency medicine.
PG  - 1328-32
LID - 10.1111/acem.12019 [doi]
AB  - The 2012 Academic Emergency Medicine consensus conference on education research
      in emergency medicine (EM) addressed various issues, including that of ethics in 
      medical education research for EM. Education research in EM is essential to
      patient care and safety, and with recent advances in simulation and the advent of
      the Milestones project, it will become even more vital. Education research in EM 
      is guided by the same principles that guide the ethical conduct of all human
      subjects' research: respect for persons, beneficence, and justice. Regulatory
      provisions and widely accepted ethical standards provide a framework for research
      in EM education; however, special considerations exist for education research. To
      ensure patient and trainee safety and to maintain the integrity of new knowledge,
      ethical considerations should remain at the forefront of EM education research.
      For EM education researchers, recognition of the vulnerability of residents,
      medical students, and others as research subjects is paramount. This article
      fills an important gap by outlining the principles guiding education research in 
      EM, exploring the ethical challenges and approaches to education research, and
      offering a framework and future directions for the ethical conduct of education
      research in EM.
CI  - (c) 2012 by the Society for Academic Emergency Medicine.
FAU - Kraus, Chadd K
AU  - Kraus CK
FAU - Guth, Todd
AU  - Guth T
FAU - Richardson, Derek
AU  - Richardson D
FAU - Kane, Bryan
AU  - Kane B
FAU - Marco, Catherine A
AU  - Marco CA
LA  - eng
PT  - Editorial
DEP - 20121205
PL  - United States
TA  - Acad Emerg Med
JT  - Academic emergency medicine : official journal of the Society for Academic
      Emergency Medicine
JID - 9418450
SB  - IM
MH  - Biomedical Research/education/*ethics
MH  - *Consensus Development Conferences as Topic
MH  - Emergency Medicine/*education/ethics
MH  - *Ethics, Research
MH  - Humans
EDAT- 2012/12/12 06:00
MHDA- 2013/06/29 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/07/01 00:00 [received]
PHST- 2012/07/02 00:00 [accepted]
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/06/29 06:00 [medline]
AID - 10.1111/acem.12019 [doi]
PST - ppublish
SO  - Acad Emerg Med. 2012 Dec;19(12):1328-32. doi: 10.1111/acem.12019. Epub 2012 Dec
      5.


PMID- 23216705
OWN - NLM
STAT- MEDLINE
DCOM- 20140702
LR  - 20211021
IS  - 1471-2458 (Electronic)
IS  - 1471-2458 (Linking)
VI  - 12
DP  - 2012 Dec 6
TI  - Occupational health risks of pathologists--results from a nationwide online
      questionnaire in Switzerland.
PG  - 1054
LID - 10.1186/1471-2458-12-1054 [doi]
AB  - BACKGROUND: Pathologists are highly trained medical professionals who play an
      essential part in the diagnosis and therapy planning of malignancies and
      inflammatory diseases. Their work is associated with potential health hazards
      including injuries involving infectious human tissue, chemicals which are assumed
      to be carcinogenic or long periods of microscope and computer work. This study
      aimed to provide the first comprehensive assessment of the health situation of
      pathologists in Switzerland. METHODS: Pathologists in Switzerland were contacted 
      via the Swiss Society of Pathologists and asked to answer an ethically approved, 
      online anonymous questionnaire comprising 48 questions on occupational health
      problems, workplace characteristics and health behaviour. RESULTS: 163
      pathologists participated in the study. Forty percent of pathologists reported
      musculoskeletal problems in the previous month. The overall prevalence was 76%.
      Almost 90% of pathologists had visual refraction errors, mainly myopia. 83% of
      pathologists had experienced occupational injuries, mostly cutting injuries, in
      their professional career; more than one fifth of participants reported cutting
      injuries in the last year. However, long lasting injuries and infectious diseases
      were rare. Depression and burnout affected every eighth pathologist. The
      prevalence of smoking was substantially below that of the general Swiss
      population. CONCLUSIONS: The results of this study suggest that more care should 
      be taken in technical and personal protective measures, ergonomic workplace
      optimisation and reduction of work overload and work inefficiencies. Despite the 
      described health risks, Swiss pathologists were optimistic about their future and
      their working situation. The high rate of ametropia and psychological problems
      warrants further study.
FAU - Fritzsche, Florian Rudolf
AU  - Fritzsche FR
AD  - Faculty of Health, Staffordshire University, Stoke on Trent, United Kingdom.
      Florian.Fritzsche@patho.ch
FAU - Ramach, Constanze
AU  - Ramach C
FAU - Soldini, Davide
AU  - Soldini D
FAU - Caduff, Rosmarie
AU  - Caduff R
FAU - Tinguely, Marianne
AU  - Tinguely M
FAU - Cassoly, Estelle
AU  - Cassoly E
FAU - Moch, Holger
AU  - Moch H
FAU - Stewart, Antony
AU  - Stewart A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121206
PL  - England
TA  - BMC Public Health
JT  - BMC public health
JID - 100968562
SB  - IM
MH  - Adult
MH  - Burnout, Professional/epidemiology
MH  - Cohort Studies
MH  - Female
MH  - *Health Behavior
MH  - *Health Status Indicators
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Musculoskeletal Diseases/*complications/epidemiology
MH  - Occupational Diseases
MH  - Occupational Exposure/statistics & numerical data
MH  - *Pathology
MH  - Risk Factors
MH  - Self Report
MH  - Surveys and Questionnaires
MH  - Switzerland/epidemiology
MH  - Workforce
MH  - Workplace/statistics & numerical data
MH  - Wounds and Injuries/epidemiology
PMC - PMC3538703
EDAT- 2012/12/12 06:00
MHDA- 2014/07/06 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/09/28 00:00 [received]
PHST- 2012/12/03 00:00 [accepted]
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2014/07/06 06:00 [medline]
AID - 1471-2458-12-1054 [pii]
AID - 10.1186/1471-2458-12-1054 [doi]
PST - epublish
SO  - BMC Public Health. 2012 Dec 6;12:1054. doi: 10.1186/1471-2458-12-1054.


PMID- 23216481
OWN - NLM
STAT- MEDLINE
DCOM- 20130523
LR  - 20181202
IS  - 1753-6405 (Electronic)
IS  - 1326-0200 (Linking)
VI  - 36
IP  - 6
DP  - 2012 Dec
TI  - Comment on 'a research participant's rights as an ethical dilemma'.
PG  - 511
LID - 10.1111/j.1753-6405.2012.00945.x [doi]
FAU - Komesaroff, Paul A
AU  - Komesaroff PA
LA  - eng
PT  - Editorial
PT  - Comment
PL  - Australia
TA  - Aust N Z J Public Health
JT  - Australian and New Zealand journal of public health
JID - 9611095
SB  - IM
CON - Aust N Z J Public Health. 2012 Dec;36(6):508-10. PMID: 23216479
MH  - Humans
MH  - *Patient Rights
MH  - *Research Subjects
EDAT- 2012/12/12 06:00
MHDA- 2013/05/25 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/05/25 06:00 [medline]
AID - 10.1111/j.1753-6405.2012.00945.x [doi]
PST - ppublish
SO  - Aust N Z J Public Health. 2012 Dec;36(6):511. doi:
      10.1111/j.1753-6405.2012.00945.x.


PMID- 23216480
OWN - NLM
STAT- MEDLINE
DCOM- 20130523
LR  - 20181202
IS  - 1753-6405 (Electronic)
IS  - 1326-0200 (Linking)
VI  - 36
IP  - 6
DP  - 2012 Dec
TI  - There is no ethical dilemma with current RCT participant unblinding practices.
PG  - 510
LID - 10.1111/j.1753-6405.2012.00944.x [doi]
FAU - Fry, Craig
AU  - Fry C
LA  - eng
PT  - Editorial
PT  - Comment
PL  - Australia
TA  - Aust N Z J Public Health
JT  - Australian and New Zealand journal of public health
JID - 9611095
SB  - IM
CON - Aust N Z J Public Health. 2012 Dec;36(6):508-10. PMID: 23216479
MH  - Humans
MH  - *Patient Rights
MH  - *Research Subjects
EDAT- 2012/12/12 06:00
MHDA- 2013/05/25 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/05/25 06:00 [medline]
AID - 10.1111/j.1753-6405.2012.00944.x [doi]
PST - ppublish
SO  - Aust N Z J Public Health. 2012 Dec;36(6):510. doi:
      10.1111/j.1753-6405.2012.00944.x.


PMID- 23216479
OWN - NLM
STAT- MEDLINE
DCOM- 20130523
LR  - 20121210
IS  - 1753-6405 (Electronic)
IS  - 1326-0200 (Linking)
VI  - 36
IP  - 6
DP  - 2012 Dec
TI  - A research participant's rights as an ethical dilemma.
PG  - 508-10
LID - 10.1111/j.1753-6405.2012.00943.x [doi]
FAU - Jane, Fiona
AU  - Jane F
FAU - Davis, Susan
AU  - Davis S
FAU - Bell, Robin
AU  - Bell R
LA  - eng
PT  - Editorial
PL  - Australia
TA  - Aust N Z J Public Health
JT  - Australian and New Zealand journal of public health
JID - 9611095
SB  - IM
CIN - Aust N Z J Public Health. 2012 Dec;36(6):510. PMID: 23216480
CIN - Aust N Z J Public Health. 2012 Dec;36(6):511. PMID: 23216481
MH  - Ethics, Research
MH  - Humans
MH  - *Patient Rights
MH  - *Research Subjects
EDAT- 2012/12/12 06:00
MHDA- 2013/05/25 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/05/25 06:00 [medline]
AID - 10.1111/j.1753-6405.2012.00943.x [doi]
PST - ppublish
SO  - Aust N Z J Public Health. 2012 Dec;36(6):508-10. doi:
      10.1111/j.1753-6405.2012.00943.x.


PMID- 23216445
OWN - NLM
STAT- MEDLINE
DCOM- 20150925
LR  - 20161020
IS  - 1365-263X (Electronic)
IS  - 0960-7439 (Linking)
VI  - 23
IP  - 6
DP  - 2013 Nov
TI  - Fluoride intake from food items in 2- to 6-year-old Brazilian children living in 
      a non-fluoridated area using a semiquantitative food frequency questionnaire.
PG  - 444-51
LID - 10.1111/ipd.12015 [doi]
AB  - BACKGROUND: Estimating fluoride intake (FI) using the 'duplicate plate' method is
      difficult and can raise ethical dilemmas. AIM: To apply a semiquantitative food
      frequency questionnaire (FFQ) to 2- to 6-year-old Brazilian children in a
      non-fluoridated area (i) to estimate their FI and (ii) to provide additional
      validity to the questionnaire by comparing the results obtained with those found 
      previously in a fluoridated municipality. DESIGN: The FFQ was administered to
      parents of 398 children residing in a non-fluoridated community. Constituents of 
      the diet were divided into solids, water and other beverages and their fluoride
      content was analysed with the electrode. Data were analysed using unpaired
      t-test. RESULTS: The mean (+/-SD) FIs from solids, water and other beverages were
      0.009 +/- 0.004, 0.001 +/- 0.001 and 0.007 +/- 0.007 mg F/kg body weight/day,
      respectively, totalling 0.017 +/- 0.009 mg F/kg body weight/day. Total FI from
      food/beverage items ingested in the non-fluoridated area was significantly lower 
      than that observed in a study previously conducted in a fluoridated area (P <
      0.0001). CONCLUSIONS: This result reinforces the use of the FFQ as a promising
      alternative to duplicate diet in order to estimate FI in children in this age
      range, with potential application in broad epidemiological surveys.
CI  - (c) 2012 John Wiley & Sons Ltd, BSPD and IAPD.
FAU - Levy, Flavia Mauad
AU  - Levy FM
AD  - Department of Biological Sciences, Bauru School of Dentistry, University of Sao
      Paulo, Bauru, SP, Brazil.
FAU - Olympio, Kelly Polido Kaneshiro
AU  - Olympio KP
FAU - Philippi, Sonia Tucunduva
AU  - Philippi ST
FAU - Buzalaf, Marilia Afonso Rabelo
AU  - Buzalaf MA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121205
PL  - England
TA  - Int J Paediatr Dent
JT  - International journal of paediatric dentistry
JID - 9107511
RN  - Q80VPU408O (Fluorides)
MH  - Brazil
MH  - Child
MH  - Child, Preschool
MH  - *Diet
MH  - Female
MH  - Fluorides/*administration & dosage
MH  - Food Analysis
MH  - Humans
MH  - Male
MH  - Surveys and Questionnaires
EDAT- 2012/12/12 06:00
MHDA- 2015/09/26 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2015/09/26 06:00 [medline]
AID - 10.1111/ipd.12015 [doi]
PST - ppublish
SO  - Int J Paediatr Dent. 2013 Nov;23(6):444-51. doi: 10.1111/ipd.12015. Epub 2012 Dec
      5.


PMID- 23216428
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20211021
IS  - 1468-0009 (Electronic)
IS  - 0887-378X (Linking)
VI  - 90
IP  - 4
DP  - 2012 Dec
TI  - Simulated patient studies: an ethical analysis.
PG  - 706-24
LID - 10.1111/j.1468-0009.2012.00680.x [doi]
AB  - CONTEXT: In connection with health care reform, the U.S. Department of Health and
      Human Services commissioned a "mystery shopper," or simulated patient study, to
      measure access to primary care. But the study was shelved because of public
      controversy over "government spying" on doctors. Opponents of the study also
      raised ethical concerns about the use of deception with human subjects without
      soliciting their informed consent. METHODS: We undertook an ethical analysis of
      the use of simulated patient techniques in health services research, with a
      particular focus on research measuring access to care. Using a case study, we
      explored relevant methodological considerations and ethical principles relating
      to deceptive research without informed consent, as well as U.S. federal
      regulations permitting exceptions to consent. FINDINGS: Several relevant
      considerations both favor and oppose soliciting consent for simulated patient
      studies. Making research participation conditional on informed consent protects
      the autonomy of research subjects and shields them from unreasonable exposure to 
      research risks. However, scientific validity is also an important ethical
      principle of human subjects research, as the net risks to subjects must be
      justified by the value to society of the knowledge to be gained. The use of
      simulated patients to monitor access is a naturalistic and scientifically sound
      experimental design that can answer important policy-relevant questions, with
      minimal risks to human subjects. As interaction between researchers and subjects 
      increases, however, so does the need for consent. CONCLUSIONS: As long as
      adequate protections of confidentiality of research data are in place, minimally 
      intrusive simulated patient research that gathers policy-relevant data on the
      health system without the consent of individuals working in that system can be
      ethically justified when the risks and burdens to research subjects are minimal
      and the research has the potential to generate socially valuable knowledge.
CI  - (c) 2012 Milbank Memorial Fund.
FAU - Rhodes, Karin V
AU  - Rhodes KV
AD  - Perelman School of Medicine and School of Social Policy & Practice, University of
      Pennsylvania, PA 19104, USA. Karin.rhodes@uphs.upenn.edu
FAU - Miller, Franklin G
AU  - Miller FG
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Milbank Q
JT  - The Milbank quarterly
JID - 8607003
SB  - IM
MH  - *Ethics, Medical
MH  - Health Services Accessibility/*ethics
MH  - Health Services Research/methods
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - *Patient Simulation
MH  - Physician-Patient Relations/*ethics
MH  - Quality Assurance, Health Care/*ethics
MH  - Research Subjects
MH  - United States
MH  - United States Dept. of Health and Human Services
PMC - PMC3530739
EDAT- 2012/12/12 06:00
MHDA- 2013/02/13 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
AID - 10.1111/j.1468-0009.2012.00680.x [doi]
PST - ppublish
SO  - Milbank Q. 2012 Dec;90(4):706-24. doi: 10.1111/j.1468-0009.2012.00680.x.


PMID- 23216263
OWN - NLM
STAT- MEDLINE
DCOM- 20130314
LR  - 20141120
IS  - 0018-5868 (Print)
IS  - 0018-5868 (Linking)
VI  - 90
IP  - 4
DP  - 2012 Oct-Dec
TI  - Cases of mobbing activities as commonly seen in the healthcare sector in the
      world and in Turkey.
PG  - 98-103
LID - 10.1080/00185868.2012.737754 [doi]
AB  - Service process on a site in the health sector does not only bring people and
      services into contact, but also all other people who share the fate of particular
      working medium. Although these people should cooperate and care about each other,
      contributing new merits to humanity with their synergy, meeting of people with
      the other people from time to time intertwine into a bitter, pain giving
      relation, like the way it happens with meeting of people with services. Owing to 
      its controversy to humanitarian nature, religious and social values, the pain
      that human beings cause to one another is occasionally disguised behind a veil,
      thus turning into a life tragedy for individuals in the background. Mobbing which
      is commonly a confrontable problem in every workplace means psychological
      violence, enclosure, harassment, molestation or endurance. This study aims to
      draw attention to the precautions required to be taken against mobbing activities
      by analyzing situations of health employees who undergo mobbing actions in Turkey
      and in the World. To achieve this, the existing studies concerning mobbing in the
      healthcare sector have been examined. In conclusion; it is determined that
      mobbing activities towards healthcare workers have limited their communication
      possibilities, damaged social relations and social image, prevented vocational
      improvement and destroyed mental health of employees. With respect to mobbing
      behavior towards health employees, we should adopt a democratic, contributing,
      and guiding administration style, we should apply organizational justice,
      excessive work inspections must be reduced, work ethics and social responsibility
      awareness must be developed, we should clearly determine the duties and
      responsibilities, physical conditions must be improved and necessary legal
      arrangements concerning the subject must be made to be able to prevent mobbing.
FAU - Ofluoglu, Gokhan
AU  - Ofluoglu G
AD  - Faculty of Economics and Administrative Sciences , Bulent Ecevit University,
      Zonguldak , Turkey.
FAU - Somunoglu, Sinem
AU  - Somunoglu S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Hosp Top
JT  - Hospital topics
JID - 0411772
MH  - *Bullying
MH  - *Global Health
MH  - *Health Care Sector/statistics & numerical data
MH  - *Health Personnel/statistics & numerical data
MH  - Humans
MH  - Turkey
MH  - *Violence/statistics & numerical data
MH  - *Workplace/statistics & numerical data
EDAT- 2012/12/12 06:00
MHDA- 2013/03/15 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/03/15 06:00 [medline]
AID - 10.1080/00185868.2012.737754 [doi]
PST - ppublish
SO  - Hosp Top. 2012 Oct-Dec;90(4):98-103. doi: 10.1080/00185868.2012.737754.


PMID- 23215934
OWN - NLM
STAT- MEDLINE
DCOM- 20130218
LR  - 20181202
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 12
IP  - 12
DP  - 2012
TI  - Building a global health ethic without doing further violence.
PG  - 59-60
LID - 10.1080/15265161.2012.738280 [doi]
FAU - Lee, Bandy X
AU  - Lee BX
AD  - Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New
      Haven, CT 06519, USA. bandy.lee@yale.edu
FAU - Young, John L
AU  - Young JL
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2012;12(12):35-54. PMID: 23215931
MH  - *Health
MH  - *Health Policy
MH  - Humans
MH  - *International Cooperation
MH  - *Social Justice
MH  - *Social Responsibility
EDAT- 2012/12/12 06:00
MHDA- 2013/02/19 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/02/19 06:00 [medline]
AID - 10.1080/15265161.2012.738280 [doi]
PST - ppublish
SO  - Am J Bioeth. 2012;12(12):59-60. doi: 10.1080/15265161.2012.738280.


PMID- 23215931
OWN - NLM
STAT- MEDLINE
DCOM- 20130218
LR  - 20121210
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 12
IP  - 12
DP  - 2012
TI  - Global health justice and governance.
PG  - 35-54
LID - 10.1080/15265161.2012.733060 [doi]
AB  - While there is a growing body of work on moral issues and global governance in
      the fields of global justice and international relations, little work has
      connected principles of global health justice with those of global health
      governance for a theory of global health. Such a theory would enable analysis and
      evaluation of the current global health system and would ethically and
      empirically ground proposals for reforming it to more closely align with moral
      values. Global health governance has been framed as an issue of national
      security, human security, human rights, and global public goods. The global
      health governance literature is essentially untethered to a theorized framework
      to illuminate or evaluate governance. This article ties global health justice and
      ethics to principles for governing the global health realm, developing a
      theoretical framework for global and domestic institutions and actors.
FAU - Ruger, Jennifer Prah
AU  - Ruger JP
AD  - Yale University, New Haven, CT 06520, USA. jennifer.ruger@yale.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CIN - Am J Bioeth. 2012;12(12):1-2. PMID: 23215917
CIN - Am J Bioeth. 2012;12(12):55-6. PMID: 23215932
CIN - Am J Bioeth. 2012;12(12):57-9. PMID: 23215933
CIN - Am J Bioeth. 2012;12(12):59-60. PMID: 23215934
CIN - Am J Bioeth. 2012;12(12):61-2. PMID: 23215935
CIN - Am J Bioeth. 2012;12(12):63. PMID: 23215936
CIN - Am J Bioeth. 2012;12(12):64-5. PMID: 23215937
CIN - Am J Bioeth. 2012;12(12):W6-8. PMID: 23215941
MH  - *Health
MH  - *Health Policy
MH  - Humans
MH  - *International Cooperation
MH  - *Social Justice
MH  - *Social Responsibility
EDAT- 2012/12/12 06:00
MHDA- 2013/02/19 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/02/19 06:00 [medline]
AID - 10.1080/15265161.2012.733060 [doi]
PST - ppublish
SO  - Am J Bioeth. 2012;12(12):35-54. doi: 10.1080/15265161.2012.733060.


PMID- 23215929
OWN - NLM
STAT- MEDLINE
DCOM- 20130218
LR  - 20181202
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 12
IP  - 12
DP  - 2012
TI  - How religious ethics can be intelligible and compatible with bioethics.
PG  - 30-1
LID - 10.1080/15265161.2012.719279 [doi]
FAU - Claassen-Luttner, J Cayenne
AU  - Claassen-Luttner JC
AD  - Emory University, Graduate Division of Religion, S244 Calllaway Center, 537 Kilgo
      Circle, Atlanta, GA 30322, USA. jclaass@emory.edu
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2012;12(12):3-10. PMID: 23215918
MH  - *Bioethics
MH  - *Cultural Characteristics
MH  - Humans
MH  - *Morals
MH  - *Religion
EDAT- 2012/12/12 06:00
MHDA- 2013/02/19 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/02/19 06:00 [medline]
AID - 10.1080/15265161.2012.719279 [doi]
PST - ppublish
SO  - Am J Bioeth. 2012;12(12):30-1. doi: 10.1080/15265161.2012.719279.


PMID- 23215663
OWN - NLM
STAT- MEDLINE
DCOM- 20130424
LR  - 20190518
IS  - 0261-1929 (Print)
IS  - 0261-1929 (Linking)
VI  - 40
IP  - 5
DP  - 2012 Oct
TI  - "How sick must your mouse be? " - An analysis of the use of animal models in
      Huntington's disease research.
PG  - 271-83
AB  - Refinement measures to improve animal welfare can ease the ethical dilemma
      between human benefit and animal harm in research with animal models of
      neurodegenerative diseases. To evaluate the potential for refinement, as well as 
      its implementation in research, we analysed papers on murine models of
      Huntington's disease (HD) published between 1999 and 2009 (n = 233). Each study
      was classified according to a four-level severity scale, in terms of the disease 
      stage that animals were allowed to reach, the execution of invasive procedures,
      and the implementation of refinement. Reports of ethical approval, and regulatory
      compliance in general, followed a clear rising trend over the years reviewed (p
      <0.001). However, the proportion of high-severity studies did not change over
      that period. Also, of the studies for which approval was reported (n = 120), 36% 
      were attributed the highest severity level. The observed discrepancy between the 
      rising motivation to affirm regulatory compliance, and the unaltered proportion
      of studies allowing animals to reach severely distressful stages, raises both
      ethical and methodological issues, which we discuss in this paper.
FAU - Franco, Nuno H
AU  - Franco NH
AD  - Institute for Molecular and Cell Biology, University of Porto, Porto, Portugal.
      nfranco@ibmc.up.pt
FAU - Olsson, I Anna S
AU  - Olsson IA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Altern Lab Anim
JT  - Alternatives to laboratory animals : ATLA
JID - 8110074
SB  - IM
MH  - Animal Experimentation/*ethics
MH  - Animals
MH  - *Disease Models, Animal
MH  - Humans
MH  - *Huntington Disease
MH  - Mice
MH  - Mice, Transgenic
EDAT- 2012/12/12 06:00
MHDA- 2013/04/25 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/04/25 06:00 [medline]
AID - 10.1177/026119291204000506 [doi]
PST - ppublish
SO  - Altern Lab Anim. 2012 Oct;40(5):271-83. doi: 10.1177/026119291204000506.


PMID- 23215662
OWN - NLM
STAT- MEDLINE
DCOM- 20130424
LR  - 20190518
IS  - 0261-1929 (Print)
IS  - 0261-1929 (Linking)
VI  - 40
IP  - 5
DP  - 2012 Oct
TI  - A review of autopsy reports on chimpanzees in or from US laboratories.
PG  - 259-69
AB  - Approximately 1000 chimpanzees are currently held in five federally owned, or
      supported, US laboratories. This study reviews 110 autopsy reports on chimpanzees
      who died from 2001-2011 in laboratories or in sanctuaries (but who were from
      laboratories), in order to glean information about their premorbid health and
      causes of death. The findings raise questions about the health status of the
      chimpanzees remaining in laboratories. Most of the chimpanzees currently held are
      not involved in active protocols. The Chimpanzee Health Improvement, Maintenance,
      and Protection (CHIMP) Act 2000 states that chimpanzees "not needed" for research
      "shall" be accepted into the federal sanctuary system, but criteria for when a
      chimpanzee is deemed "not needed" are not given. The assessment of "not needed"
      lies with the Secretary of Health and Human Services, who has left the decision
      to the discretion of the laboratories. This autopsy review revealed that the
      majority of the chimpanzees who died in laboratories had been suffering from
      significant chronic or incurable illnesses, and most often had multi-system
      diseases that should have made them ineligible for future research, on
      scientific, as well as ethical, grounds. The study's findings are significant in 
      establishing the need for defined criteria for chimpanzee retirement to
      sanctuary.
CI  - 2012 FRAME.
FAU - Capaldo, Theodora
AU  - Capaldo T
AD  - New England Anti-Vivisection Society, Boston, MA, USA. tcapaldo@neavs.org
FAU - Peppercorn, Marge
AU  - Peppercorn M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Altern Lab Anim
JT  - Alternatives to laboratory animals : ATLA
JID - 8110074
SB  - IM
MH  - Animal Experimentation
MH  - Animals
MH  - *Autopsy
MH  - Female
MH  - Male
MH  - *Pan troglodytes
MH  - United States
EDAT- 2012/12/12 06:00
MHDA- 2013/04/25 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/04/25 06:00 [medline]
AID - 10.1177/026119291204000505 [doi]
PST - ppublish
SO  - Altern Lab Anim. 2012 Oct;40(5):259-69. doi: 10.1177/026119291204000505.


PMID- 23214296
OWN - NLM
STAT- MEDLINE
DCOM- 20130104
LR  - 20140926
IS  - 1899-5276 (Print)
IS  - 1899-5276 (Linking)
VI  - 21
IP  - 1
DP  - 2012 Jan-Feb
TI  - Pelvi-caliceal collecting system in swine--authors own anatomical classification.
PG  - 27-33
AB  - BACKGROUND: Experiments on humans and their organs produce legal, moral and
      ethical dilemmas. Nowadays, the use of domestic swine as an experimental animal
      is increasing steadily. Thus it is important to know the structure and
      characteristics of swine organs. OBJECTIVES: The purpose of the study was to
      investigate the shape, dimensions and volume of the renal collecting system in
      swine, based on authors own outline of division of this anatomical structure, as 
      well as comparing some features of the pelvi-caliceal collecting system for swine
      and man. MATERIAL AND METHODS: The study was carried out on 36 kidneys of adult
      swine (Sus scrofa domestica) of both sexes. The authors generated the corrosion
      specimens by applying Plastogen G. The authors took the density of the stained
      and hardened mass into consideration and weighed the corrosion casts. Then the
      authors could estimate the volume of the pelvi-caliceal collecting system by
      applying the formula which states that volume is a quotient of weight and
      density. RESULTS: The mean dimensions of the pelvi-caliceal collecting system in 
      swine are: length--69.2 mm, width--23.5 mm, thickness--15.8 mm; the volume of
      this system is on average 7.0 cm3. The renal collecting system originates from
      the minor calices which are in the shape of flattened cones. Their mean
      dimensions are: diameter--9.3 mm, height--3 mm. The major calices, taking the
      form ofa cylindrical body, emerge from the minor calices. The mean dimensions of 
      the primary major calices inserted in the renal pelvis are: length--.0 mm,
      diameter--6 mm; the primary calices which come into secondary ones: length--7 mm,
      diameter--3 mm; the secondary major calices: length--.3 mm, diameter--0 mm. The
      renal pelvis is the last part of the pelvi-caliceal collecting system and takes
      the form of a distorted triangle. Its mean dimensions are: width--.1 mm,
      height--.7 mm. CONCLUSIONS: The pelvi-caliceal collecting system in swine is a
      massive structure of high volume, with a well-developed structure of the renal
      calices and swollen renal pelvis. The studied structure is more massive and its
      volume is about three times larger than that in man. Despite some disadvantages, 
      perhaps in the future a swine kidney will be transplanted into a man, but
      nowadays due to lack of dissection material it may be used as a teaching model or
      in experimental research.
FAU - Szymanski, Jacek
AU  - Szymanski J
AD  - Department of Normal and Clinical Anatomy, Medical University of Lodz, Poland.
      jacek.szymanski1@umed.lodz.pl
FAU - Konarska, Sylwia
AU  - Konarska S
FAU - Polguj, Michal
AU  - Polguj M
FAU - Oszukowski, Piotr
AU  - Oszukowski P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Poland
TA  - Adv Clin Exp Med
JT  - Advances in clinical and experimental medicine : official organ Wroclaw Medical
      University
JID - 101138582
SB  - IM
MH  - Animals
MH  - Corrosion Casting
MH  - Female
MH  - Humans
MH  - Kidney Calices/*anatomy & histology
MH  - Kidney Pelvis/*anatomy & histology
MH  - Male
MH  - Sus scrofa
EDAT- 2012/12/12 06:00
MHDA- 2013/01/05 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/01/05 06:00 [medline]
PST - ppublish
SO  - Adv Clin Exp Med. 2012 Jan-Feb;21(1):27-33.


PMID- 23214168
OWN - NLM
STAT- MEDLINE
DCOM- 20130103
LR  - 20121207
IS  - 0033-2674 (Print)
IS  - 0033-2674 (Linking)
VI  - 46
IP  - 4
DP  - 2012 Jul-Aug
TI  - [Munchausen syndrome by proxy in a forensic psychiatric evaluation--the
      description of a case and ethical controversy].
PG  - 677-89
AB  - AIM: Presentation of the difficulties in diagnosing Munchausen syndrome by proxy.
      METHOD: Comparison of four different conclusions in forensic psychiatric opinions
      issued in one case, due to the need of answering to the questions of the court,
      in what periods and why was the deterioration of the child's health, in
      connection with an allegation that the mother has acted to his detriment. In the 
      first medical-legal opinion the treating physician, while being the head of the
      ward and the person informing the police of the action against a child by the
      mother, recognised Munchausen syndrome by proxy. The second opinion was delivered
      by a psychologist, who stated that the mother distinguished the introspective
      attitude characterised by excessive, exaggerated accuracy, thoroughness, and did 
      not give a unambiguous answer to the questions of the court. In the third opinion
      the experts accepted that the functioning of the subject does not create a threat
      to life and health of the child. The fourth opinion developed by the authors of
      this paper noted that in the analysed medical records of the childs'
      hospitalisation, no arguments were found to recognise Munchausen syndrome by
      proxy. RESULTS. In the conducted extended ambulant study of the subject and the
      analysis of the medical documentation of the 31 hospitalisations of the child
      showed that the improvement of the child's health was not associated in exclusion
      of pushing aside the mother from the child, but was the result of the consistency
      of the therapeutic treatment team, the continuation and the modification of the
      treatment. CONCLUSIONS: In appointing the expert, the art. 196 of the Code of
      Criminal Procedure should be considered, which states that the expert should not 
      be the treating doctor, because his opinion loses value impartiality. Diagnosis
      of Munchausen Syndrome by proxy itself stirs up numerous controversies..
FAU - Heitzman, Janusz
AU  - Heitzman J
AD  - Klinika Psychiatrii Sadowej IPiN w Warszawie.
FAU - Opio, Malgorzata
AU  - Opio M
FAU - Ruzikowska, Alfreda
AU  - Ruzikowska A
FAU - Pilszyk, Anna
AU  - Pilszyk A
LA  - pol
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Przeniesiony zespol Munchausena w opinii sadowo- -psychiatrycznej--opis przypadku
      i kontrowersje etyczne.
PL  - Poland
TA  - Psychiatr Pol
JT  - Psychiatria polska
JID - 0103314
SB  - IM
MH  - Clinical Competence
MH  - Diagnosis, Differential
MH  - Disease Management
MH  - *Ethics, Medical
MH  - Forensic Medicine/methods
MH  - Forensic Psychiatry/*ethics
MH  - Humans
MH  - Mental Disorders/diagnosis/therapy
MH  - *Mother-Child Relations
MH  - Mothers/psychology
MH  - Munchausen Syndrome by Proxy/*diagnosis/*therapy
MH  - Professional-Family Relations/*ethics
EDAT- 2012/12/12 06:00
MHDA- 2013/01/04 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/01/04 06:00 [medline]
PST - ppublish
SO  - Psychiatr Pol. 2012 Jul-Aug;46(4):677-89.


PMID- 23214116
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20190724
IS  - 0021-5384 (Print)
IS  - 0021-5384 (Linking)
VI  - 101
IP  - 10
DP  - 2012 Oct 10
TI  - [Series: For attending physicians; professionalism; the question of ethics
      consultation].
PG  - 3012-8
FAU - Asai, Atsushi
AU  - Asai A
AD  - Department of Bioethics, Kumamoto University Graduate School of Medicine, Japan.
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Nihon Naika Gakkai Zasshi
JT  - Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal
      Medicine
JID - 19130210R
SB  - IM
MH  - *Ethics Consultation
MH  - Japan
MH  - Philosophy, Medical
MH  - Professional Practice/*standards
MH  - Social Environment
EDAT- 2012/12/12 06:00
MHDA- 2013/03/13 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
AID - 10.2169/naika.101.3012 [doi]
PST - ppublish
SO  - Nihon Naika Gakkai Zasshi. 2012 Oct 10;101(10):3012-8. doi:
      10.2169/naika.101.3012.


PMID- 23214002
OWN - NLM
STAT- MEDLINE
DCOM- 20130108
LR  - 20121207
IS  - 0255-2930 (Print)
IS  - 0255-2930 (Linking)
VI  - 32
IP  - 11
DP  - 2012 Nov
TI  - [Mr. Chen Ying-long of chengjiang acupuncture school: a brief introduction].
PG  - 1049-53
AB  - Through consultation of the historical literatures on Mr. CHEN Ying-long,
      investigating his teaching experiences in Xiamen Hospital of TCM and Xiamen
      University, the characteristics of his educational idea on
      acupuncture-moxibustion, are found as follows: great significance is found in the
      dissemination of Chengjiang acupuncture school in Minnan area of China and abroad
      through the combination of the succession of education from a masters to
      disciples and the classroom teaching; importance is attached to medical ethics,
      and priority is put on building up ethics and teaching by precept and example. In
      order to inherit the Chengjiang acupuncture school, Mr. CHEN focuses on fostering
      a proper studying method, emphasizes on the basic skills of acupuncture,
      reinforces clinical practice and techniques, edits books, and imparts knowledge
      and solves doubts.
FAU - Zhu, An-Ning
AU  - Zhu AN
AD  - Department of TCM, Medical College of Xiamen University, Xiamen 361005, Fujian
      Province, China. 418988788@qq.com
FAU - Zhang, Jian-Bin
AU  - Zhang JB
FAU - Sun, Xiao-Zhong
AU  - Sun XZ
FAU - Meng, Xian-Jun
AU  - Meng XJ
LA  - chi
PT  - Biography
PT  - English Abstract
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Zhen Jiu
JT  - Zhongguo zhen jiu = Chinese acupuncture & moxibustion
JID - 8600658
SB  - IM
MH  - Acupuncture/*education/*history
MH  - Acupuncture Therapy/history
MH  - China
MH  - History, 19th Century
MH  - History, 20th Century
MH  - Humans
MH  - Moxibustion/history
MH  - Schools/history
PS  - Chen YL
FPS - Chen, Ying-long
EDAT- 2012/12/12 06:00
MHDA- 2013/01/09 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/01/09 06:00 [medline]
PST - ppublish
SO  - Zhongguo Zhen Jiu. 2012 Nov;32(11):1049-53.


PMID- 23213943
OWN - NLM
STAT- MEDLINE
DCOM- 20130108
LR  - 20171116
IS  - 0350-6134 (Print)
IS  - 0350-6134 (Linking)
VI  - 36
IP  - 3
DP  - 2012 Sep
TI  - Pathological pregnancy and psychological symptoms in women.
PG  - 847-52
AB  - Pregnancy is followed by many physiologic, organic and psychological changes and 
      disorders, which can become more serious in pregnancy followed by complications, 
      especially in women with pathological conditions during pregnancy. The purpose of
      this study was to find out and analyze the prevalence and intensity of
      psychological disorders in women with pathological conditions during pregnancy
      and compare it with conditions in pregnant women who had normal development of
      pregnancy. The research is approved by the Ethical committee of the Mostar
      University Hospital Center, and it was made in accordance with Helsinki
      declaration and good clinical practices. The research conducted section for
      pathology of pregnancy of Department for gynecology and obstetrics of the Mostar 
      University Hospital Center. It included 82 pregnant women with disorders in
      pregnancy developement and control group consisted of pregnant women who had
      normal development of pregnancy. The research work was conducted from September
      2007 to August 2008 in Mostar University Hospital Center. Pregnant women had
      Standard and laboratory tests, Ultrasound. CTG examinations were done for all
      pregnant women and additional tests for those women with complications during
      pregnancy. Pregnant women completed sociobiographical, obstetrical-clinical and
      psychological SCL 90-R questionnaire. Pregnant women with pathological pregnancy 
      exibited significantly more psychological symptoms in comparison to pregnant
      women with normal pregnancy (p < 0.001 to p = 0.004). Frequency and intensity of 
      psychical symptoms and disorders statisticly are more characteristic in
      pathological pregnancy (61%/40.6%). The statistical data indicate a significantly
      higher score of psychological disorders in those pregnant women with primary
      school education (p = 0.050), those who take more than 60% carbohydrates (p =
      0.001), those with pathological CTG records (p < 0.001), those with pathological 
      ultrasound results (p < 0.001 to 0.216) and those pregnant women with medium
      obesity and obesity (p = 0.046). Body mass index (BMI) during normal pregnancy
      development is lower (p = 0.002) but the levels of glucose, triglycerides,
      cholesterol, HDL and LDL in blood are higher Blood pressure in pregnant women
      with pathological pregnancy was statistically significantly higher (p < 0.001).
      Diagnostic criteria for the metabolic syndrome were found in 19 pregnant women
      with the pathological pregnancy. Statistically, in those women, a significantly
      higher appearance of psychological symptoms and disorders was observed in
      comparison to the pregnant women without metabolic syndrome (p < 0.001). The
      research has shown that 87.8% from all pregnant women included in this study have
      been hospitalized due to premature birth, hypertensive disorders, and diabetes in
      pregnancy, and also due to bleeding in the second and third trimester of
      pregnancy.
FAU - Bjelanovic, Vedran
AU  - Bjelanovic V
AD  - Mostar University Hospital Centre, Department of Gynecology and Obstetrics,
      Mostar, Bosnia and Herzegovina. vedranbjelanovic@yahoo.com
FAU - Babic, Dragan
AU  - Babic D
FAU - Oreskovic, Slavko
AU  - Oreskovic S
FAU - Tomic, Vajdana
AU  - Tomic V
FAU - Martinac, Marko
AU  - Martinac M
FAU - Juras, Josip
AU  - Juras J
LA  - eng
PT  - Journal Article
PL  - Croatia
TA  - Coll Antropol
JT  - Collegium antropologicum
JID - 8003354
SB  - IM
MH  - Adult
MH  - Cross-Sectional Studies
MH  - Female
MH  - Hemorrhage/epidemiology/psychology
MH  - Humans
MH  - Mental Disorders/*epidemiology
MH  - Metabolic Syndrome/*epidemiology/*psychology
MH  - Obesity/epidemiology/psychology
MH  - Pregnancy
MH  - Pregnancy Complications/*epidemiology/*psychology
EDAT- 2012/12/12 06:00
MHDA- 2013/01/09 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/01/09 06:00 [medline]
PST - ppublish
SO  - Coll Antropol. 2012 Sep;36(3):847-52.


PMID- 23213793
OWN - NLM
STAT- MEDLINE
DCOM- 20130107
LR  - 20121206
IS  - 1592-7830 (Print)
IS  - 1592-7830 (Linking)
VI  - 34
IP  - 3
DP  - 2012 Jul-Sep
TI  - [Hazard identification and risk evaluation in the metal industry: the epigenetic 
      challenge].
PG  - 223-8
AB  - The contribution of scientific knowledge to workplace health and safety measures 
      is becoming more and more relevant. To identify hazards, an increasing number of 
      mechanistic markers (of exposure, of effect, of individual susceptibility) are
      now available. To be effective, prevention measures should take into
      consideration not just the hazards, but also the risk which may vary among
      different populations and across individuals exposed to the same hazard. A new,
      extremely promising class of molecular markers of gene-environment interaction
      comes from epigenetics research (e.g., DNA methylation, histone modification,
      mi-RNA). A recent epigenetic epidemiology study in workers exposed to metals and 
      PM in the metal industry disclosed their potential role as predictor of extremely
      early effects on gene expression regulating inflammation and blood coagulation
      function. A possible, worrisome development in applying mechanistic knowledge in 
      exposure monitoring and exposed individuals' surveillance is to divert the
      attention from the control of exposure and put the focus on the screening of
      susceptible individuals only. This raises ethical, social and legal issues which 
      may ultimately impact throughout the practice of occupational and environmental
      health.
FAU - Bertazzi, P A
AU  - Bertazzi PA
AD  - Dipartimento di Scienze Cliniche e di Comunita, Universita degli Studi, Milano,
      Italy. cdldevoto@unimi.it
FAU - Bollati, V
AU  - Bollati V
FAU - Bonzini, M
AU  - Bonzini M
LA  - ita
PT  - English Abstract
PT  - Journal Article
TT  - Le prospettive nello studio dei rischi in metallurgia: la sfida epigenetica.
PL  - Italy
TA  - G Ital Med Lav Ergon
JT  - Giornale italiano di medicina del lavoro ed ergonomia
JID - 9712708
SB  - IM
MH  - *Epigenesis, Genetic
MH  - Gene-Environment Interaction
MH  - Humans
MH  - *Metallurgy
MH  - Occupational Diseases/*genetics
MH  - *Occupational Exposure
MH  - Risk Assessment
EDAT- 2012/12/12 06:00
MHDA- 2013/01/08 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/12/11 06:00 [entrez]
PHST- 2012/12/12 06:00 [pubmed]
PHST- 2013/01/08 06:00 [medline]
PST - ppublish
SO  - G Ital Med Lav Ergon. 2012 Jul-Sep;34(3):223-8.


PMID- 23213141
OWN - NLM
STAT- MEDLINE
DCOM- 20130703
LR  - 20161125
IS  - 1743-0593 (Electronic)
IS  - 1743-0585 (Linking)
VI  - 98
IP  - 1
DP  - 2013 Feb
TI  - Going legal.
PG  - 26-30
LID - 10.1136/archdischild-2012-302095 [doi]
AB  - A 16-year-old girl is admitted with a paracetamol overdose, but refuses
      treatment. This article explores the legal, ethical and practical aspects of this
      case, which led ultimately to an application to the court for a judicial order.
FAU - Lopez, Tony
AU  - Lopez T
AD  - Department of Child Health, Derriford Hospital, Derriford, Plymouth PL6 8DH, UK. 
      tony.lopez@nhs.net
FAU - Howells, Rachel
AU  - Howells R
FAU - Lindsay, Simon
AU  - Lindsay S
LA  - eng
PT  - Journal Article
DEP - 20121204
PL  - England
TA  - Arch Dis Child Educ Pract Ed
JT  - Archives of disease in childhood. Education and practice edition
JID - 101220684
RN  - 362O9ITL9D (Acetaminophen)
SB  - IM
MH  - Acetaminophen/*poisoning
MH  - Adolescent
MH  - Drug Overdose/*drug therapy
MH  - Emergency Medical Services/*ethics/*legislation & jurisprudence
MH  - Female
MH  - Humans
MH  - Minors/*legislation & jurisprudence
MH  - Treatment Refusal/*ethics/*legislation & jurisprudence
MH  - United Kingdom
EDAT- 2012/12/06 06:00
MHDA- 2013/07/05 06:00
CRDT- 2012/12/06 06:00
PHST- 2012/12/06 06:00 [entrez]
PHST- 2012/12/06 06:00 [pubmed]
PHST- 2013/07/05 06:00 [medline]
AID - archdischild-2012-302095 [pii]
AID - 10.1136/archdischild-2012-302095 [doi]
PST - ppublish
SO  - Arch Dis Child Educ Pract Ed. 2013 Feb;98(1):26-30. doi:
      10.1136/archdischild-2012-302095. Epub 2012 Dec 4.


PMID- 23212177
OWN - NLM
STAT- MEDLINE
DCOM- 20131209
LR  - 20211021
IS  - 1573-3599 (Electronic)
IS  - 1059-7700 (Linking)
VI  - 22
IP  - 3
DP  - 2013 Jun
TI  - When the topic is you: genetic counselor responses to prenatal patients' requests
      for self-disclosure.
PG  - 358-73
LID - 10.1007/s10897-012-9554-2 [doi]
AB  - A limited amount of research indicates patient requests play a major role in
      genetic counselors' self-disclosure decisions and that disclosure and
      non-disclosure responses to patient requests may differentially affect genetic
      counseling processes. Studies further suggest patient requests may be more common
      in prenatal settings, particularly when counselors are pregnant. Empirical
      evidence is limited however, concerning the nature of patient requests. This
      study explored genetic counselors' experiences of prenatal patients' requests for
      self-disclosure. Four major research questions were: (1) What types of questions 
      do prenatal patients ask that invite self-disclosure?; (2) Do pregnant genetic
      counselors have unique experiences with prenatal patient disclosure requests?;
      (3) How do genetic counselors typically respond to disclosure requests?; and (4) 
      What strategies are effective and ineffective in responding to disclosure
      requests? One hundred seventy-six genetic counselors completed an online survey
      and 40 also participated in telephone interviews. Inductive analysis of 21
      interviews revealed patient questions vary, although questions about counselor
      demographics are most common, and patients are more likely to ask pregnant
      counselors questions about their personal pregnancy decisions. Participants
      reported greater discomfort with self-disclosure requests during pregnancy, yet
      also disclosing more frequently during pregnancy. Counselor responses included
      personal self-disclosure, professional self-disclosure, redirection, and
      declining to disclose. Factors perceived as influencing disclosure included:
      topic, patient motivations, timing of request, quality of counseling
      relationship, patient characteristics, and ethical/legal responsibilities.
      Disclosure practices changed over time for most counselors. Additional findings, 
      practice implications, and research recommendations are discussed.
FAU - Balcom, Jessica R
AU  - Balcom JR
AD  - Division of Laboratory Genetics, Molecular Genetics Laboratory, Mayo Clinic, 200 
      First Street SW, Rochester, MN 55905, USA.
FAU - Veach, Patricia McCarthy
AU  - Veach PM
FAU - Bemmels, Heather
AU  - Bemmels H
FAU - Redlinger-Grosse, Krista
AU  - Redlinger-Grosse K
FAU - LeRoy, Bonnie S
AU  - LeRoy BS
LA  - eng
PT  - Journal Article
DEP - 20121206
PL  - United States
TA  - J Genet Couns
JT  - Journal of genetic counseling
JID - 9206865
SB  - IM
MH  - Adult
MH  - Female
MH  - *Genetic Counseling
MH  - Humans
MH  - Male
MH  - Pregnancy
MH  - *Prenatal Care
MH  - *Self Disclosure
EDAT- 2012/12/06 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/12/06 06:00
PHST- 2012/08/09 00:00 [received]
PHST- 2012/11/14 00:00 [accepted]
PHST- 2012/12/06 06:00 [entrez]
PHST- 2012/12/06 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1007/s10897-012-9554-2 [doi]
PST - ppublish
SO  - J Genet Couns. 2013 Jun;22(3):358-73. doi: 10.1007/s10897-012-9554-2. Epub 2012
      Dec 6.


PMID- 23210701
OWN - NLM
STAT- MEDLINE
DCOM- 20130207
LR  - 20170214
IS  - 2165-0799 (Print)
IS  - 2165-0799 (Linking)
VI  - 60
IP  - 12
DP  - 2012 Dec
TI  - Pain management in occupational health: a guide for non-narcotic pain relief.
PG  - 525-30; quiz 531
LID - 10.3928/21650799-20121128-74 [doi]
AB  - Narcotic pain management is currently a topic of concern in the United States;
      the latest concerns are both legal and ethical. Narcotics are frequently
      prescribed medications that, when improperly used or supervised, can cause death.
      Legal concerns include prescribing narcotics without performing detailed
      health-related evaluations, not recognizing those seeking drugs for personal
      recreational use, and clients diverting drugs to others for financial gain.
      Injured workers need to have pain controlled and be mentally safe to perform
      their job duties. This article identifies types of pain, comorbidities, and
      alternative methods of pain management beyond narcotic therapy, as well as
      discusses guidelines used to initiate narcotic therapy when needed.
CI  - Copyright 2012, SLACK Incorporated.
FAU - Ferriolo, Angela E
AU  - Ferriolo AE
AD  - Universit of South Florida Sunshire Education and Research Center, Tampa, FL,
      USA. aferriol@health.usf.edu
FAU - Conlon, Helen Acree
AU  - Conlon HA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Workplace Health Saf
JT  - Workplace health & safety
JID - 101575677
RN  - 0 (Analgesics, Non-Narcotic)
MH  - Analgesics, Non-Narcotic/*therapeutic use
MH  - Education, Nursing, Continuing
MH  - Humans
MH  - Occupational Health Nursing/*methods/*standards
MH  - Pain Management/*methods
MH  - Practice Guidelines as Topic
EDAT- 2012/12/06 06:00
MHDA- 2013/02/08 06:00
CRDT- 2012/12/06 06:00
PHST- 2012/07/09 00:00 [received]
PHST- 2012/11/05 00:00 [accepted]
PHST- 2012/12/06 06:00 [entrez]
PHST- 2012/12/06 06:00 [pubmed]
PHST- 2013/02/08 06:00 [medline]
AID - 10.1177/216507991206001204 [doi]
PST - ppublish
SO  - Workplace Health Saf. 2012 Dec;60(12):525-30; quiz 531. doi:
      10.1177/216507991206001204.


PMID- 23210125
OWN - NLM
STAT- MEDLINE
DCOM- 20131115
LR  - 20121204
IS  - 0300-8495 (Print)
IS  - 0300-8495 (Linking)
VI  - 41
IP  - 12
DP  - 2012 Dec
TI  - The informal curriculum - general practitioner perceptions of ethics in clinical 
      practice.
PG  - 981-4
AB  - BACKGROUND: Australian medical students should graduate with an understanding of 
      the principles of medical law and ethics, and their application to clinical
      settings. Although student perspectives have been studied previously, the teacher
      experience of ethical issues also needs to be understood, particularly in the
      general practice setting. METHODS: Interviews were conducted with a convenience
      sample of 13 general practitioner teachers. They were asked to reflect on common 
      and/or important ethical issues in their day-to-day practice. An inductive
      thematic analysis of the data was performed by two investigators, who reached a
      consensus on major themes using an iterative, dialogic process. RESULTS:
      Participants reported negotiating ethical issues frequently. Major themes
      included patient-doctor relationships, professional differences, truth-telling,
      ethically 'grey' areas and the personal demands of ethical decision making.
      DISCUSSION: General practitioners in this study describe sometimes needing to
      apply judgement and compromise in situations involving legal or ethical issues,
      in order to act in the best interests of patients and to successfully negotiate
      the patient-doctor relationship. Students learning in this clinical context may
      perceive mixed messages and ethical lapses in these challenging 'grey' areas. The
      ethical acumen and emotional resilience of both students and clinical teachers
      may be enhanced by ongoing reflective discussion with colleagues.
FAU - Sturman, Nancy J
AU  - Sturman NJ
AD  - University of Queensland, Brisbane, Queensland, Australia. n.sturman1@uq.edu.au
FAU - Parker, Malcolm
AU  - Parker M
FAU - van Driel, Mieke L
AU  - van Driel ML
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Aust Fam Physician
JT  - Australian family physician
JID - 0326701
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Decision Making
MH  - Education, Medical, Undergraduate
MH  - Ethics, Medical/*education
MH  - *Faculty, Medical
MH  - General Practice/*ethics
MH  - General Practitioners/ethics/*psychology
MH  - Humans
MH  - Physician-Patient Relations/ethics
EDAT- 2012/12/05 06:00
MHDA- 2013/11/16 06:00
CRDT- 2012/12/05 06:00
PHST- 2012/12/05 06:00 [entrez]
PHST- 2012/12/05 06:00 [pubmed]
PHST- 2013/11/16 06:00 [medline]
PST - ppublish
SO  - Aust Fam Physician. 2012 Dec;41(12):981-4.


PMID- 23210113
OWN - NLM
STAT- MEDLINE
DCOM- 20131115
LR  - 20220408
IS  - 0300-8495 (Print)
IS  - 0300-8495 (Linking)
VI  - 41
IP  - 12
DP  - 2012 Dec
TI  - Thinking through the medication list - appropriate prescribing and deprescribing 
      in robust and frail older patients.
PG  - 924-8
AB  - BACKGROUND: Medicines in older patients have the potential to provide great gains
      as well as significant harms. OBJECTIVE: To provide an ethically sound, evidence 
      based discussion of the benefits and harms of medications commonly used in
      primary care among older patients. DISCUSSION: Appropriate prescribing and
      deprescribing (drug withdrawal) for older patients requires a thorough
      understanding of the individual, their therapeutic goals, the benefits and risks 
      of all of their medicines, and medical ethics. There is very limited evidence on 
      the safety and efficacy of medicines in older adults, particularly in the frail, 
      who often have multiple comorbidities and functional impairments. In robust older
      patients, therapy usually aims to delay or cure disease and to minimise
      functional impairment. In frail older patients, symptom control, maintaining
      function and addressing end-of-life issues become the main priorities. Optimising
      medicines is a time-consuming, multidisciplinary process that requires extensive 
      communication, frequent monitoring and review, and has a major clinical impact.
FAU - Hilmer, Sarah N
AU  - Hilmer SN
AD  - Northern Clinical School, Sydney Medical School, University of Sydney, New South 
      Wales, Australia. sarah.hilmer@sydney.edu.au
FAU - Gnjidic, Danijela
AU  - Gnjidic D
FAU - Le Couteur, David G
AU  - Le Couteur DG
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Aust Fam Physician
JT  - Australian family physician
JID - 0326701
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Fibrinolytic Agents)
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
RN  - 0 (Platelet Aggregation Inhibitors)
RN  - 0 (Sulfonylurea Compounds)
SB  - IM
MH  - Aged
MH  - Anti-Bacterial Agents/adverse effects/therapeutic use
MH  - Antihypertensive Agents/adverse effects/therapeutic use
MH  - Beneficence
MH  - Comorbidity
MH  - Fibrinolytic Agents/adverse effects/therapeutic use
MH  - Frail Elderly
MH  - Health Status
MH  - Humans
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects/therapeutic use
MH  - Patient Care Planning
MH  - Platelet Aggregation Inhibitors/adverse effects/therapeutic use
MH  - *Polypharmacy
MH  - *Practice Patterns, Physicians'/ethics
MH  - Primary Health Care/ethics/*methods
MH  - Risk Assessment
MH  - Sulfonylurea Compounds/adverse effects/therapeutic use
EDAT- 2012/12/05 06:00
MHDA- 2013/11/16 06:00
CRDT- 2012/12/05 06:00
PHST- 2012/12/05 06:00 [entrez]
PHST- 2012/12/05 06:00 [pubmed]
PHST- 2013/11/16 06:00 [medline]
PST - ppublish
SO  - Aust Fam Physician. 2012 Dec;41(12):924-8.


PMID- 23210086
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121205
LR  - 20220408
IS  - 2277-9175 (Print)
IS  - 2277-9175 (Linking)
VI  - 1
DP  - 2012
TI  - Viral and nonviral delivery systems for gene delivery.
PG  - 27
LID - 10.4103/2277-9175.98152 [doi]
AB  - Gene therapy is the process of introducing foreign genomic materials into host
      cells to elicit a therapeutic benefit. Although initially the main focus of gene 
      therapy was on special genetic disorders, now diverse diseases with different
      patterns of inheritance and acquired diseases are targets of gene therapy. There 
      are 2 major categories of gene therapy, including germline gene therapy and
      somatic gene therapy. Although germline gene therapy may have great potential,
      because it is currently ethically forbidden, it cannot be used; however, to date 
      human gene therapy has been limited to somatic cells. Although numerous viral and
      nonviral gene delivery systems have been developed in the last 3 decades, no
      delivery system has been designed that can be applied in gene therapy of all
      kinds of cell types in vitro and in vivo with no limitation and side effects. In 
      this review we explain about the history of gene therapy, all types of gene
      delivery systems for germline (nuclei, egg cells, embryonic stem cells,
      pronuclear, microinjection, sperm cells) and somatic cells by viral [retroviral, 
      adenoviral, adeno association, helper-dependent adenoviral systems, hybrid
      adenoviral systems, herpes simplex, pox virus, lentivirus, Epstein-Barr virus)]
      and nonviral systems (physical: Naked DNA, DNA bombardant, electroporation,
      hydrodynamic, ultrasound, magnetofection) and (chemical: Cationic lipids,
      different cationic polymers, lipid polymers). In addition to the above-mentioned,
      advantages, disadvantages, and practical use of each system are discussed.
FAU - Nayerossadat, Nouri
AU  - Nayerossadat N
AD  - Molecular Genetic Laboratory, Alzahra Hospital, Isfahan University of Medical
      Sciences, Isfahan, Iran ; Pediatric Inherited Disease Research Center, Isfahan
      University of Medical Sciences, Isfahan, Iran.
FAU - Maedeh, Talebi
AU  - Maedeh T
FAU - Ali, Palizban Abas
AU  - Ali PA
LA  - eng
PT  - Journal Article
DEP - 20120706
PL  - India
TA  - Adv Biomed Res
JT  - Advanced biomedical research
JID - 101586897
PMC - PMC3507026
OTO - NOTNLM
OT  - Chemical delivery
OT  - gene therapy
OT  - non viral delivery systems
OT  - physical delivery
OT  - viral delivery systems
EDAT- 2012/12/05 06:00
MHDA- 2012/12/05 06:01
CRDT- 2012/12/05 06:00
PHST- 2011/12/13 00:00 [received]
PHST- 2012/03/10 00:00 [accepted]
PHST- 2012/12/05 06:00 [entrez]
PHST- 2012/12/05 06:00 [pubmed]
PHST- 2012/12/05 06:01 [medline]
AID - 10.4103/2277-9175.98152 [doi]
AID - ABR-1-27 [pii]
PST - ppublish
SO  - Adv Biomed Res. 2012;1:27. doi: 10.4103/2277-9175.98152. Epub 2012 Jul 6.


PMID- 23209983
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121205
LR  - 20220318
IS  - 2141-9248 (Print)
IS  - 2141-9248 (Linking)
VI  - 2
IP  - 1
DP  - 2012 Jan
TI  - Depression in patients with epilepsy: a study from enugu, South East Nigeria.
PG  - 10-3
LID - 10.4103/2141-9248.96929 [doi]
AB  - BACKGROUND: Depression is a common psychiatric disorder in epilepsy patients. A
      bidirectional interaction is thought to be present between epilepsy and
      depression. There are few studies of this relationship in Nigerian Africans.
      OBJECTIVES: This was a cross-sectional study of the frequency and pattern of
      depression in a cohort of epilepsy patients in Enugu, South East Nigeria.
      MATERIALS AND METHODS: Adult patients with epilepsy seen at the University of
      Nigeria Teaching Hospital, Enugu, from May to September 2009 were assessed for
      depression using the Becks Inventory for Depression. Informed consent was
      obtained from each patient. Clinical data obtained were analyzed using
      Statistical Package for the Social Sciences, version 15. The hospital's ethical
      review committee approved the study. RESULTS: I0 n all, 83 subjects were studied 
      (50 males and 33 females). They were aged from 18 to 75 years, with an average of
      29.87 years. Most subjects were <25 years of age, single (53, 64%) and had at
      least secondary school education (65, 78%). Depression was present in 71 (85.5%) 
      subjects - minimal 57 (68.7%), mild 10 (12%), and moderate 4 (4.8%). No case of
      severe depression was seen. Patients <25 years of age were the most affected.
      Depression was not significantly associated with age, gender, seizure type, or
      educational level. CONCLUSION: A significant proportion of Nigerian African
      epilepsy patients have depression, which may be easily overlooked, with
      far-reaching consequences on patients' quality of life, morbidity, and mortality 
      rates. There is need to regularly assess for and manage epilepsy-related
      depression in this population.
FAU - Onwuekwe, Io
AU  - Onwuekwe I
AD  - Neurology Unit, Department of Medicine, University of Nigeria Teaching Hospital, 
      P. M. B. 01129 Enugu, Nigeria.
FAU - Ekenze, Os
AU  - Ekenze O
FAU - Bzeala-Adikaibe
AU  - Bzeala-Adikaibe
FAU - Ejekwu, Ju
AU  - Ejekwu J
LA  - eng
PT  - Journal Article
PL  - India
TA  - Ann Med Health Sci Res
JT  - Annals of medical and health sciences research
JID - 101585351
PMC - PMC3507132
OTO - NOTNLM
OT  - Depression
OT  - Epilepsy
OT  - Nigerian Africans
EDAT- 2012/12/05 06:00
MHDA- 2012/12/05 06:01
CRDT- 2012/12/05 06:00
PHST- 2012/12/05 06:00 [entrez]
PHST- 2012/12/05 06:00 [pubmed]
PHST- 2012/12/05 06:01 [medline]
AID - 10.4103/2141-9248.96929 [doi]
AID - AMHSR-2-10 [pii]
PST - ppublish
SO  - Ann Med Health Sci Res. 2012 Jan;2(1):10-3. doi: 10.4103/2141-9248.96929.


PMID- 23209103
OWN - NLM
STAT- MEDLINE
DCOM- 20130222
LR  - 20211021
IS  - 1098-4275 (Electronic)
IS  - 0031-4005 (Linking)
VI  - 131
IP  - 1
DP  - 2013 Jan
TI  - Retention and research use of residual newborn screening bloodspots.
PG  - 120-7
LID - 10.1542/peds.2012-0852 [doi]
AB  - The storage and use of residual newborn screening dried blood specimens has
      generated significant controversy in the past 5 years, primarily because of
      public concerns over the lack of parental knowledge and consent for these
      activities. State policies addressing the management of these specimens vary
      widely, and there is currently little guidance to aid new state policy
      development to address the concerns of program professionals, investigators, and 
      the general public. This article offers guidance for state policy based on
      multiple sources of data, including public attitudes, professional statements,
      state experience, and an analysis of the ethical, social, legal, and biomedical
      issues from a multidisciplinary group of scholars. This guidance will be useful
      for state programs that seek to develop policies that are informed by a
      contemporary analysis of the key ethical, legal, and social aspects of this
      practice. This article represents the work of the authors and does not represent 
      American Academy of Pediatrics policy.
FAU - Botkin, Jeffrey R
AU  - Botkin JR
AD  - University of Utah, Salt Lake City, Utah 84112, USA. jeffrey.botkin@hsc.utah.edu
FAU - Goldenberg, Aaron J
AU  - Goldenberg AJ
FAU - Rothwell, Erin
AU  - Rothwell E
FAU - Anderson, Rebecca A
AU  - Anderson RA
FAU - Lewis, Michelle Huckaby
AU  - Lewis MH
LA  - eng
GR  - R01 HG004970/HG/NHGRI NIH HHS/United States
GR  - R01HG058854/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20121203
PL  - United States
TA  - Pediatrics
JT  - Pediatrics
JID - 0376422
SB  - IM
CIN - Am J Bioeth. 2015;15(9):47-9. PMID: 26305753
MH  - Biomedical Research/ethics/*standards
MH  - Blood Specimen Collection/ethics/*standards
MH  - Dried Blood Spot Testing/ethics/*standards
MH  - Guideline Adherence/ethics/*standards
MH  - Health Policy
MH  - Humans
MH  - Infant, Newborn
MH  - Neonatal Screening/ethics/*standards
MH  - *Parental Consent/ethics
MH  - United States
PMC - PMC3529945
EDAT- 2012/12/05 06:00
MHDA- 2013/02/23 06:00
CRDT- 2012/12/05 06:00
PHST- 2012/12/05 06:00 [entrez]
PHST- 2012/12/05 06:00 [pubmed]
PHST- 2013/02/23 06:00 [medline]
AID - peds.2012-0852 [pii]
AID - 10.1542/peds.2012-0852 [doi]
PST - ppublish
SO  - Pediatrics. 2013 Jan;131(1):120-7. doi: 10.1542/peds.2012-0852. Epub 2012 Dec 3.


PMID- 23209003
OWN - NLM
STAT- MEDLINE
DCOM- 20130918
LR  - 20121204
IS  - 1522-1229 (Electronic)
IS  - 1043-4046 (Linking)
VI  - 36
IP  - 4
DP  - 2012 Dec
TI  - Using a classic paper by Evarts as a platform for discussing cortical control of 
      skeletal muscle in awake, behaving primates.
PG  - 246-50
LID - 10.1152/advan.00103.2012 [doi]
AB  - A growing portion of premedical curricula is being devoted to the study of
      physiological mechanisms underlying animal behavior. In the present article, I
      describe an activity centered around a classic Journal of Neurophysiology paper
      by Edward V. Evarts that lays the foundation for students to investigate common
      behavioral and physiological techniques used to study motor control in primates. 
      Students will leave this activity being able to 1) critically assess behavioral, 
      electromyographic, and single unit (extracellular) neurophysiological data
      typically acquired by behavioral neurophysiologists; 2) provide physiological
      evidence that the primate precentral gyrus (primary motor cortex) controls
      voluntary movements of the wrist; 3) intelligently discuss hypotheses concerning 
      the role of the primary motor cortex in the generation of movement in mammalian
      species; and 4) discuss the ethical implications of using mammalian species as
      model organisms. The skills and background knowledge gained in this activity lay 
      the platform for advanced study of scientific investigations into sensory, motor,
      and cognitive processes in undergraduate, graduate, or medical school curricula.
FAU - Cecala, Aaron L
AU  - Cecala AL
AD  - Department of Biology, Elizabethtown College, Pennsylvania 17022, USA.
      cecalaa@etown.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Adv Physiol Educ
JT  - Advances in physiology education
JID - 100913944
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*physiology
MH  - Humans
MH  - Motor Cortex/*physiology
MH  - Movement/*physiology
MH  - Muscle, Skeletal/*physiology
MH  - Primates
MH  - Wakefulness/*physiology
EDAT- 2012/12/05 06:00
MHDA- 2013/09/21 06:00
CRDT- 2012/12/05 06:00
PHST- 2012/12/05 06:00 [entrez]
PHST- 2012/12/05 06:00 [pubmed]
PHST- 2013/09/21 06:00 [medline]
AID - 36/4/246 [pii]
AID - 10.1152/advan.00103.2012 [doi]
PST - ppublish
SO  - Adv Physiol Educ. 2012 Dec;36(4):246-50. doi: 10.1152/advan.00103.2012.


PMID- 23208201
OWN - NLM
STAT- MEDLINE
DCOM- 20131125
LR  - 20211203
IS  - 1049-7323 (Print)
IS  - 1049-7323 (Linking)
VI  - 23
IP  - 2
DP  - 2013 Feb
TI  - Being, knowing, and doing: a phronetic approach to constructing grounded theory
      with Aboriginal Australian partners.
PG  - 275-88
LID - 10.1177/1049732312467853 [doi]
AB  - Researchers working with Aboriginal Australian partners are confronted with an
      array of historical, social, and political complexities which make it difficult
      to come to theoretical and methodological decisions. In this article, we describe
      a culturally safe and respectful framework that maintains the intellectual and
      theoretical rigor expected of academic research. As an Aboriginal woman and two
      non-Aboriginal women, we discuss the arguments and some of the challenges of
      using grounded theory methods in Aboriginal Australian contexts, giving examples 
      from our studies of Aboriginal empowerment processes. We argue that the ethics of
      care and responsibility embedded in Aboriginal research methodologies fit well
      with grounded theory studies of Aboriginal social processes. We maintain that
      theory development grounded in data provides useful insights into the processes
      for raising the health, well-being, and prosperity of Aboriginal Australians.
FAU - Bainbridge, Roxanne
AU  - Bainbridge R
AD  - The Cairns Institute, James Cook University, PO Box 6811, Cairns, Queensland
      4870, Australia. roxanne.bainbridge@jcu.edu.au
FAU - Whiteside, Mary
AU  - Whiteside M
FAU - McCalman, Janya
AU  - McCalman J
LA  - eng
PT  - Journal Article
DEP - 20121203
PL  - United States
TA  - Qual Health Res
JT  - Qualitative health research
JID - 9202144
MH  - Adult
MH  - Attitude to Health/*ethnology
MH  - Australia/ethnology
MH  - Biomedical Research/ethics/*methods
MH  - *Cultural Characteristics
MH  - Data Collection/*methods
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Native Hawaiian or Other Pacific Islander/*psychology
MH  - Power, Psychological
MH  - *Research Design
MH  - Social Behavior
EDAT- 2012/12/05 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/12/05 06:00
PHST- 2012/12/05 06:00 [entrez]
PHST- 2012/12/05 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 1049732312467853 [pii]
AID - 10.1177/1049732312467853 [doi]
PST - ppublish
SO  - Qual Health Res. 2013 Feb;23(2):275-88. doi: 10.1177/1049732312467853. Epub 2012 
      Dec 3.


PMID- 23208133
OWN - NLM
STAT- MEDLINE
DCOM- 20130417
LR  - 20190923
IS  - 0253-9772 (Print)
IS  - 0253-9772 (Linking)
VI  - 34
IP  - 11
DP  - 2012 Nov
TI  - [The research progress of human genetic diversity in China].
PG  - 1351-64
AB  - Human genetic diversity refers to genomic variation among races, ethnic groups,
      isolated populations and individuals worldwide, and is one major resource and
      tool on discovering human evolution and migration, interaction between genetic
      background and environment, and factors associated with human diseases and
      health. China has abundant and valuable resource of human genetic diversity due
      to 56 ethnic groups and a large population accounting for one fifth of the total 
      population in the world. After decades of efforts, a large number of research
      data on human genetic diversity have been accumulated in China, and some of
      outcomes reach advanced international level. This review mainly focuses on the
      recent progress and outcomes achieved in applying genetic markers including
      morphological markers, biochemical and immunological markers and DNA markers in
      research of genetic diversity, and the application of mitochondrial DNA, Y
      chromosomal DNA, HLA and others in research of the origin and relationship of
      Chinese ethic groups, and the origin and mi-of modern East Asian populations.
      This review also summarizes the advances in the research fields of preservation
      and utilization of Chinese genetic resource, identification of genes associated
      with disease selective and adaptive for natural pressure, application of whole
      genome association study and next generation sequencing, and Chinese human genome
      as well.
FAU - Yang, Zhao-Qing
AU  - Yang ZQ
AD  - Department of Medical Genetics, Chinese Academy of Medical Sciences, Kunming,
      China. zyang@imbcams.com.cn
FAU - Chu, Jia-You
AU  - Chu JY
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - China
TA  - Yi Chuan
JT  - Yi chuan = Hereditas
JID - 9436478
RN  - 0 (DNA, Mitochondrial)
SB  - IM
MH  - China
MH  - DNA, Mitochondrial/genetics
MH  - Genetic Predisposition to Disease
MH  - *Genetic Variation
MH  - *Genome, Human
MH  - Humans
MH  - Microsatellite Repeats
MH  - Polymorphism, Single Nucleotide
EDAT- 2012/12/05 06:00
MHDA- 2013/04/18 06:00
CRDT- 2012/12/05 06:00
PHST- 2012/12/05 06:00 [entrez]
PHST- 2012/12/05 06:00 [pubmed]
PHST- 2013/04/18 06:00 [medline]
AID - 0253-9772(2012)11-1351-14 [pii]
AID - 10.3724/sp.j.1005.2012.01351 [doi]
PST - ppublish
SO  - Yi Chuan. 2012 Nov;34(11):1351-64. doi: 10.3724/sp.j.1005.2012.01351.


PMID- 23207710
OWN - NLM
STAT- MEDLINE
DCOM- 20130711
LR  - 20191112
IS  - 1678-2690 (Electronic)
IS  - 0001-3765 (Linking)
VI  - 84
IP  - 4
DP  - 2012 Dec
TI  - Comparative studies of two dimensional and three dimensional ultrasonic nuchal
      translucency in trisomy assessments.
PG  - 1157-68
LID - S0001-37652012000400030 [pii]
AB  - Current two-dimensional (2D) ultrasonic marker measurements are inherent with
      intra- and inter-observer variability limitations. The objective of this paper is
      to investigate the performance of conventional 2D ultrasonic marker measurements 
      and proposed programmable interactive three-dimensional (3D) marker evaluation.
      This is essentially important to analyze that the measurement on 3D volumetric
      measurement possesses higher impact and reproducibility vis-a-vis 2D measurement.
      Twenty three cases of prenatal ultrasound examination were obtained from
      collaborating hospital after Ethical Committee's approval. The measured 2D
      ultrasonic marker is Nuchal Translucency or commonly abbreviated as NT.
      Descriptive analysis of both 2D and 3D ultrasound measurement were calculated.
      Three trial measurements were taken for each method. Both data were tested with
      One-Sample Kolmogorov-Smirnov Test and results indicate that markers measurements
      were distributed normally with significant parametric values at 0.621 and 0.596
      respectively. Computed mean and standard deviation for both measurement methods
      are 1.4495 +/- 0.46490 (2D) and 1.3561 +/- 0.50994 (3D). ANOVA test shows that
      computerized 3D measurements were found to be insignificantly different from the 
      mean of conventional 2D at the significance level of 0.05. With Pearson's
      correlation coefficient value or R = 0.861, the result proves strong positive
      linear correlation between 2D and 3D ultrasonic measurements. Reproducibility and
      accuracy of 3D ultrasound in NT measurement was significantly increased compared 
      with 2D B-mode ultrasound prenatal assessment. 3D reconstructed imaging has
      higher clinical values compare to 2D ultrasound images with less diagnostics
      information.
FAU - Wee, Lai K
AU  - Wee LK
AD  - Biotechnology Research Alliance, Universiti Teknologi Malaysia, Skudai, Johor,
      Malaysia. kwlai2@live.utm.my
FAU - Chai, Hum Y
AU  - Chai HY
FAU - Samsury, Sharul R Bin
AU  - Samsury SR
FAU - Mujamil, Naizaithull F Binti
AU  - Mujamil NF
FAU - Supriyanto, Eko
AU  - Supriyanto E
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Brazil
TA  - An Acad Bras Cienc
JT  - Anais da Academia Brasileira de Ciencias
JID - 7503280
SB  - IM
MH  - Algorithms
MH  - Analysis of Variance
MH  - Female
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Imaging, Three-Dimensional
MH  - Nuchal Translucency Measurement/*methods
MH  - Observer Variation
MH  - Pregnancy
MH  - Reproducibility of Results
MH  - Trisomy/*diagnosis
EDAT- 2012/12/05 06:00
MHDA- 2013/07/13 06:00
CRDT- 2012/12/05 06:00
PHST- 2011/06/29 00:00 [received]
PHST- 2012/03/05 00:00 [accepted]
PHST- 2012/12/05 06:00 [entrez]
PHST- 2012/12/05 06:00 [pubmed]
PHST- 2013/07/13 06:00 [medline]
AID - S0001-37652012000400030 [pii]
AID - 10.1590/s0001-37652012000400030 [doi]
PST - ppublish
SO  - An Acad Bras Cienc. 2012 Dec;84(4):1157-68. doi: 10.1590/s0001-37652012000400030.


PMID- 23207189
OWN - NLM
STAT- MEDLINE
DCOM- 20130627
LR  - 20141120
IS  - 1095-8304 (Electronic)
IS  - 0195-6663 (Linking)
VI  - 62
DP  - 2013 Mar
TI  - Promising ethical arguments for product differentiation in the organic food
      sector. A mixed methods research approach.
PG  - 133-42
LID - 10.1016/j.appet.2012.11.015 [doi]
LID - S0195-6663(12)00467-9 [pii]
AB  - Ethical consumerism is a growing trend worldwide. Ethical consumers' expectations
      are increasing and neither the Fairtrade nor the organic farming concept covers
      all the ethical concerns of consumers. Against this background the aim of this
      research is to elicit consumers' preferences regarding organic food with
      additional ethical attributes and their relevance at the market place. A mixed
      methods research approach was applied by combining an Information Display Matrix,
      Focus Group Discussions and Choice Experiments in five European countries.
      According to the results of the Information Display Matrix, 'higher animal
      welfare', 'local production' and 'fair producer prices' were preferred in all
      countries. These three attributes were discussed with Focus Groups in depth,
      using rather emotive ways of labelling. While the ranking of the attributes was
      the same, the emotive way of communicating these attributes was, for the most
      part, disliked by participants. The same attributes were then used in Choice
      Experiments, but with completely revised communication arguments. According to
      the results of the Focus Groups, the arguments were presented in a factual
      manner, using short and concise statements. In this research step, consumers in
      all countries except Austria gave priority to 'local production'. 'Higher animal 
      welfare' and 'fair producer prices' turned out to be relevant for buying
      decisions only in Germany and Switzerland. According to our results, there is
      substantial potential for product differentiation in the organic sector through
      making use of production standards that exceed existing minimum regulations. The 
      combination of different research methods in a mixed methods approach proved to
      be very helpful. The results of earlier research steps provided the basis from
      which to learn - findings could be applied in subsequent steps, and used to
      adjust and deepen the research design.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Zander, Katrin
AU  - Zander K
AD  - Department of Agricultural and Food Marketing at the University of Kassel,
      Steinstrasse 19, D-37213 Witzenhausen, Germany. katrin.zander@vti.bund.de.
FAU - Stolz, Hanna
AU  - Stolz H
FAU - Hamm, Ulrich
AU  - Hamm U
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121130
PL  - England
TA  - Appetite
JT  - Appetite
JID - 8006808
SB  - IM
MH  - Agriculture/*ethics
MH  - Animal Welfare
MH  - Austria
MH  - Choice Behavior/*ethics
MH  - Commerce
MH  - Communication
MH  - *Consumer Behavior
MH  - Emotions
MH  - Focus Groups
MH  - *Food Labeling
MH  - *Food Preferences
MH  - Food Supply/*ethics
MH  - *Food, Organic
MH  - Germany
MH  - Humans
MH  - Switzerland
EDAT- 2012/12/05 06:00
MHDA- 2013/06/29 06:00
CRDT- 2012/12/05 06:00
PHST- 2012/02/02 00:00 [received]
PHST- 2012/11/12 00:00 [revised]
PHST- 2012/11/20 00:00 [accepted]
PHST- 2012/12/05 06:00 [entrez]
PHST- 2012/12/05 06:00 [pubmed]
PHST- 2013/06/29 06:00 [medline]
AID - S0195-6663(12)00467-9 [pii]
AID - 10.1016/j.appet.2012.11.015 [doi]
PST - ppublish
SO  - Appetite. 2013 Mar;62:133-42. doi: 10.1016/j.appet.2012.11.015. Epub 2012 Nov 30.


PMID- 23206872
OWN - NLM
STAT- MEDLINE
DCOM- 20131028
LR  - 20211203
IS  - 1873-5010 (Electronic)
IS  - 1569-1993 (Linking)
VI  - 12
IP  - 4
DP  - 2013 Jul
TI  - Phenotypic expression of the 3120+1G>A mutation in non-Caucasian children with
      cystic fibrosis in South Africa.
PG  - 363-6
LID - 10.1016/j.jcf.2012.11.003 [doi]
LID - S1569-1993(12)00207-X [pii]
AB  - INTRODUCTION: Cystic fibrosis (CF) is the most common genetic disorder in
      Caucasians. Presentation of CF in non-Caucasians is less well studied. OBJECTIVE:
      This audit was undertaken to determine the phenotypic expression of the 3120+1G>A
      mutation in black and mixed race children in South Africa. METHODS: A
      multi-centre retrospective chart review of clinical, laboratory and spirometry
      data of non-Caucasian CF patients in four CF centres in South Africa was
      collected. Data was collected at diagnosis and after a five-year follow-up
      period. Ethical approval was granted for the study. RESULTS: A total of 30
      participants were enrolled of whom 14 (47%) were homozygous and 16 (53%)
      heterozygous for the 3120+1G>A mutation. The mean age of diagnosis was 13 months.
      Twenty-four (80%) patients had malnutrition (mean weight z-score -3.6) or failure
      to thrive (77%) at presentation. Twenty (67%) presented with non-specific
      abdominal symptoms, whilst fifteen (50%) had recurrent respiratory tract
      infections. Pseudomonas aeruginosa was detected at a mean age of 21 months. The
      mean FEV1 was 73% predicted (95% CI 54.0-91.1) at study entry and 68% predicted
      (95% CI 49.74-87.06) at follow-up. CONCLUSION: Failure to thrive and a diagnosis 
      of protein energy malnutrition (kwashiorkor) are the common presenting features
      of CF in children with the 3120+1G>A mutation. Meconium ileus is a rare
      presenting feature of CF in black and mixed race children with this deletion in
      South Africa.
CI  - Copyright (c) 2012 European Cystic Fibrosis Society. Published by Elsevier B.V.
      All rights reserved.
FAU - Masekela, R
AU  - Masekela R
AD  - Department of Paediatrics and Child Health, Steve Biko Academic Hospital,
      University of Pretoria, Pretoria, South Africa. refiloe.masekela@up.ac.za
FAU - Zampoli, M
AU  - Zampoli M
FAU - Westwood, A T
AU  - Westwood AT
FAU - White, D A
AU  - White DA
FAU - Green, R J
AU  - Green RJ
FAU - Olorunju, S
AU  - Olorunju S
FAU - Kwofie-Mensah, M
AU  - Kwofie-Mensah M
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20121130
PL  - Netherlands
TA  - J Cyst Fibros
JT  - Journal of cystic fibrosis : official journal of the European Cystic Fibrosis
      Society
JID - 101128966
RN  - 126880-72-6 (Cystic Fibrosis Transmembrane Conductance Regulator)
SB  - IM
MH  - Blacks/*genetics
MH  - Cystic Fibrosis/*genetics
MH  - Cystic Fibrosis Transmembrane Conductance Regulator/*genetics
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - *Mutation
MH  - Phenotype
MH  - Retrospective Studies
MH  - South Africa
EDAT- 2012/12/05 06:00
MHDA- 2013/10/29 06:00
CRDT- 2012/12/05 06:00
PHST- 2012/09/19 00:00 [received]
PHST- 2012/10/30 00:00 [revised]
PHST- 2012/11/02 00:00 [accepted]
PHST- 2012/12/05 06:00 [entrez]
PHST- 2012/12/05 06:00 [pubmed]
PHST- 2013/10/29 06:00 [medline]
AID - S1569-1993(12)00207-X [pii]
AID - 10.1016/j.jcf.2012.11.003 [doi]
PST - ppublish
SO  - J Cyst Fibros. 2013 Jul;12(4):363-6. doi: 10.1016/j.jcf.2012.11.003. Epub 2012
      Nov 30.


PMID- 23206688
OWN - NLM
STAT- MEDLINE
DCOM- 20130919
LR  - 20121204
IS  - 2162-5514 (Electronic)
IS  - 0074-7742 (Linking)
VI  - 107
DP  - 2012
TI  - Ethical aspects of neuromodulation.
PG  - 315-32
LID - 10.1016/B978-0-12-404706-8.00016-4 [doi]
LID - B978-0-12-404706-8.00016-4 [pii]
AB  - Invasive and noninvasive technological neuromodulation of the brain has major
      impact on individual and social ethical issues like autonomy and justice. It also
      challenges the foundations of ethics itself by dealing with the preconditions of 
      moral judgment and behavior. Ethical issues related to personal, clinical, and
      scientific integrity are addressed. Eight prevailing problems are identified with
      regard to anticipation, desperation, psychosocial impact, and authenticity,
      expansion of clinical application, enhancement, criterion of treatment
      resistance, and framework for research. It is argued for comprehensive
      multidisciplinary care during the treatment and adaptation process, for
      multifaceted data collection, and against a strict criterion of treatment
      resistance.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Woopen, Christiane
AU  - Woopen C
AD  - Institute for the History of Medicine and Medical Ethics, Research Unit Ethics,
      University of Cologne, Cologne, Germany. christiane.woopen@uni-koeln.de
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Int Rev Neurobiol
JT  - International review of neurobiology
JID - 0374740
RN  - 0 (Neurotransmitter Agents)
SB  - IM
MH  - Animals
MH  - Brain/pathology/*physiology
MH  - Deep Brain Stimulation/*ethics
MH  - *Ethics, Medical
MH  - Humans
MH  - Nervous System Diseases/psychology/*therapy
MH  - Neurotransmitter Agents/*physiology
EDAT- 2012/12/05 06:00
MHDA- 2013/09/21 06:00
CRDT- 2012/12/05 06:00
PHST- 2012/12/05 06:00 [entrez]
PHST- 2012/12/05 06:00 [pubmed]
PHST- 2013/09/21 06:00 [medline]
AID - B978-0-12-404706-8.00016-4 [pii]
AID - 10.1016/B978-0-12-404706-8.00016-4 [doi]
PST - ppublish
SO  - Int Rev Neurobiol. 2012;107:315-32. doi: 10.1016/B978-0-12-404706-8.00016-4.


PMID- 23206646
OWN - NLM
STAT- MEDLINE
DCOM- 20130614
LR  - 20121204
IS  - 1558-349X (Electronic)
IS  - 1546-1440 (Linking)
VI  - 9
IP  - 12
DP  - 2012 Dec
TI  - Punishing the lemon: the ethics of actuarial fairness.
PG  - 887-93
LID - 10.1016/j.jacr.2012.09.012 [doi]
LID - S1546-1440(12)00541-8 [pii]
AB  - The Patient Protection and Affordable Care Act rejects the notion that actuarial 
      fairness is a normative ideal. The author discusses the ethics of actuarial
      fairness and attempts to draw a distinction between actuarial fairness and moral 
      fairness. The ethics of wellness programs are discussed with both actuarial
      fairness and moral fairness in mind. The potential tension between physicians and
      patients in the zealous pursuit of healthy goals is described. Finally, the
      logical end point of actuarial fairness with the widespread availability of
      genetic information is highlighted.
CI  - Copyright (c) 2012 American College of Radiology. Published by Elsevier Inc. All 
      rights reserved.
FAU - Jha, Saurabh
AU  - Jha S
AD  - Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania
      19104, USA. saurabh.jha@uphs.upenn.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Coll Radiol
JT  - Journal of the American College of Radiology : JACR
JID - 101190326
SB  - IM
MH  - Actuarial Analysis/*ethics
MH  - Delivery of Health Care/*ethics
MH  - Health Services Accessibility/*ethics
MH  - Patient Protection and Affordable Care Act/*ethics
MH  - Social Justice/*ethics
MH  - United States
EDAT- 2012/12/05 06:00
MHDA- 2013/06/15 06:00
CRDT- 2012/12/05 06:00
PHST- 2012/08/28 00:00 [received]
PHST- 2012/09/04 00:00 [accepted]
PHST- 2012/12/05 06:00 [entrez]
PHST- 2012/12/05 06:00 [pubmed]
PHST- 2013/06/15 06:00 [medline]
AID - S1546-1440(12)00541-8 [pii]
AID - 10.1016/j.jacr.2012.09.012 [doi]
PST - ppublish
SO  - J Am Coll Radiol. 2012 Dec;9(12):887-93. doi: 10.1016/j.jacr.2012.09.012.


PMID- 23206347
OWN - NLM
STAT- MEDLINE
DCOM- 20130524
LR  - 20151119
IS  - 1743-6109 (Electronic)
IS  - 1743-6095 (Linking)
VI  - 9
IP  - 12
DP  - 2012 Dec
TI  - Periurethral injection of polyacrylamide hydrogel for the treatment of stress
      urinary incontinence: the impact on female sexual function.
PG  - 3255-63
LID - 10.1111/j.1743-6109.2012.02955.x [doi]
AB  - INTRODUCTION: Urinary incontinence can negatively affect sexual function. AIM: To
      investigate sexual function in female patients treated for urodynamic stress
      incontinence (USI) by periurethral injections. METHODS: This double-center
      prospective study included 29 female patients who were treated for USI by
      periurethral injections of polyacrylamide hydrogel (Bulkamid((R)); Ethicon
      Women's Health and Urology, Contura, Denmark). MAIN OUTCOME MEASURES: Patients
      answered the International Consultation on Incontinence Questionnaire short form,
      the Incontinence Impact Questionnaire, and the Patient Global Improvement
      Impression. The Pelvic Organ Prolapse/Urinary Incontinence Sexual
      Questionnaire-12 (PISQ-12) was used to evaluate sexual function at baseline and
      at 1-year follow-up. Patients were also asked to rate their sexual activity by
      using a 10-mm visual analog scale at baseline and at 12-month follow-up.
      Subjective and objective success was examined. RESULTS: All patients were
      discharged on the same day of treatment and there was no intraoperative
      complication. At 1-year follow-up, the subjective success rate was 89.7% and the 
      objective success rate was 79.3%. At 1 year from the first treatment, all the 23 
      sexually active patients continued to have regular sexual life. Six women
      reestablished sexual activity after the treatment. The total PISQ-12 scores
      showed a significant improvement in quality of sexual life of patients who were
      sexually active before surgery. CONCLUSIONS: Periurethral injections of
      polyacrylamide hydrogel to treat USI are clinically effective and safe. These
      surgical procedures cause significant improvements in sexual function and sexual 
      satisfaction of patients.
CI  - (c) 2012 International Society for Sexual Medicine.
FAU - Leone Roberti Maggiore, Umberto
AU  - Leone Roberti Maggiore U
AD  - Department of Obstetrics and Gynecology, San Martino Hospital and National
      Institute for Cancer Research, University of Genoa, Genoa, Italy. ulrm@libero.it
FAU - Alessandri, Franco
AU  - Alessandri F
FAU - Medica, Mauro
AU  - Medica M
FAU - Gabelli, Maurizio
AU  - Gabelli M
FAU - Venturini, Pier Luigi
AU  - Venturini PL
FAU - Ferrero, Simone
AU  - Ferrero S
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - Netherlands
TA  - J Sex Med
JT  - The journal of sexual medicine
JID - 101230693
RN  - 0 (Acrylic Resins)
RN  - 0 (Gels)
RN  - 0 (polyacrylamide gels)
SB  - IM
MH  - Acrylic Resins/*therapeutic use
MH  - Adult
MH  - Aged
MH  - Female
MH  - Follow-Up Studies
MH  - Gels
MH  - Humans
MH  - Injections
MH  - Middle Aged
MH  - Prospective Studies
MH  - *Quality of Life
MH  - *Sexual Behavior
MH  - Surveys and Questionnaires
MH  - Urethra
MH  - Urinary Incontinence, Stress/*therapy
EDAT- 2012/12/05 06:00
MHDA- 2013/05/28 06:00
CRDT- 2012/12/05 06:00
PHST- 2012/12/05 06:00 [entrez]
PHST- 2012/12/05 06:00 [pubmed]
PHST- 2013/05/28 06:00 [medline]
AID - 10.1111/j.1743-6109.2012.02955.x [doi]
AID - S1743-6095(15)33841-8 [pii]
PST - ppublish
SO  - J Sex Med. 2012 Dec;9(12):3255-63. doi: 10.1111/j.1743-6109.2012.02955.x.


PMID- 23206344
OWN - NLM
STAT- MEDLINE
DCOM- 20130524
LR  - 20121204
IS  - 1743-6109 (Electronic)
IS  - 1743-6095 (Linking)
VI  - 9
IP  - 12
DP  - 2012 Dec
TI  - Ethical aspects of sexual medicine. Internet, vibrators, and other sex aids: toys
      or therapeutic instruments?
PG  - 2994-3001
LID - 10.1111/jsm.12018 [doi]
AB  - INTRODUCTION: Sexual health is the result of a complex interplay between social, 
      relational, intrapsychic, and medical aspects. Sexual health care professionals
      (SHCP) may face several ethical issues. Some SHCP prescribe Internet pornography 
      for both diagnosis and therapy and some others directly sell vibrators and sex
      aids in their offices. METHODS: Five scientists, with different perspectives,
      debate the ethical aspects in the clinical practice of the SHCP. MAIN OUTCOME
      MEASURE: To give to the Journal of Sexual Medicine's reader enough data to form
      her/his own opinion on an important ethical topic. RESULTS: Expert #1, who is
      Controversy's Section Editor, together with two coworkers, expert
      psycho-sexologists, reviews data from literature regarding the use of the
      Internet in the SHCP. Expert #2 argues that licensed professionals, who treat
      sexual problems, should not sell sexual aids such as vibrators, lubricants,
      erotica, and instructional DVDs to their clients. On the other hand, Expert #3 is
      in favor of the possibility, for the patient, to directly purchase sexual aids
      from the SHCP in order to avoid embarrassment, confusion, and non-adherence to
      treatment. CONCLUSION: Evidence and intelligence would suggest that both the
      Internet (in selected subjects) and the vibrators (in the correct clinical
      setting), with the due efforts in counseling the patients and tailoring their
      therapy, are not-harmful, excellent tools in promoting sexual health.
CI  - (c) 2012 International Society for Sexual Medicine.
FAU - Jannini, Emmanuele A
AU  - Jannini EA
AD  - School of Sexology, Course of Medical Sexology, Department of Biotechnological
      and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
      emmanuele.jannini@univaq.it
FAU - Limoncin, Erika
AU  - Limoncin E
FAU - Ciocca, Giacomo
AU  - Ciocca G
FAU - Buehler, Stephanie
AU  - Buehler S
FAU - Krychman, Michael
AU  - Krychman M
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Sex Med
JT  - The journal of sexual medicine
JID - 101230693
RN  - 0 (Lubricants)
SB  - IM
MH  - Commerce/*ethics
MH  - Erotica
MH  - Humans
MH  - Internet
MH  - Lubricants
MH  - Reproductive Health/*ethics
MH  - Sexual Behavior
EDAT- 2012/12/05 06:00
MHDA- 2013/05/28 06:00
CRDT- 2012/12/05 06:00
PHST- 2012/12/05 06:00 [entrez]
PHST- 2012/12/05 06:00 [pubmed]
PHST- 2013/05/28 06:00 [medline]
AID - 10.1111/jsm.12018 [doi]
AID - S1743-6095(15)33825-X [pii]
PST - ppublish
SO  - J Sex Med. 2012 Dec;9(12):2994-3001. doi: 10.1111/jsm.12018.


PMID- 23206224
OWN - NLM
STAT- MEDLINE
DCOM- 20131021
LR  - 20191210
IS  - 1365-2648 (Electronic)
IS  - 0309-2402 (Linking)
VI  - 69
IP  - 8
DP  - 2013 Aug
TI  - Moral distress in end-of-life care in the intensive care unit.
PG  - 1869-80
LID - 10.1111/jan.12053 [doi]
AB  - AIM: To explore moral distress in relatives doctors and nurses, in end-of-life
      care decision-making, in the adult intensive care unit. BACKGROUND: Many deaths
      in intensive care involve decisions about withholding and withdrawing therapy,
      potentially triggering moral distress. Moral distress occurs when individuals
      feel constrained from acting in accordance with moral choice, or act against
      moral judgement, generating painful, unresolved emotions, and problems that
      continue long after an event. Prior research has focused mainly on nurses; less
      is known about doctors' experiences and occurrence and impact on relatives is
      unknown. DESIGN: A narrative inquiry case study approach, funded by a Northern
      Ireland Health and Social Care Doctorate Fellowship Award (April 2011). METHODS: 
      In-depth digitally recorded interviews will be conducted with relatives, doctors,
      and nurses involved in end-of-life cases comprising: (1) withdrawal of therapy,
      including circulatory death organ donation; (2) non-escalation of therapy; and
      (3) brain stem death with a request for organ donation. Relatives will be offered
      the opportunity to share their experiences on 'Healthtalkonline' by copyrighting 
      audio-visual interviews to the Health Experiences Research Group, Oxford
      University. Research Ethics Committee approval was obtained (April 2012).
      DISCUSSION: This is the first time that moral distress is explored, in a case
      approach, among relatives, doctors, and nurses intimately involved in end-of-life
      decisions in intensive care. Dissemination of findings will make a large
      contribution to international knowledge and understanding in this area and alert 
      healthcare professionals and relatives to an otherwise under-recognized, but
      potentially detrimental, experience. Findings will inform education, practice,
      and policy.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - St Ledger, Una
AU  - St Ledger U
AD  - Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical
      Sciences, Queen's University of Belfast, Belfast, UK. ustledger01@qub.ac.uk
FAU - Begley, Ann
AU  - Begley A
FAU - Reid, Joanne
AU  - Reid J
FAU - Prior, Lindsay
AU  - Prior L
FAU - McAuley, Danny
AU  - McAuley D
FAU - Blackwood, Bronagh
AU  - Blackwood B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121204
PL  - England
TA  - J Adv Nurs
JT  - Journal of advanced nursing
JID - 7609811
SB  - IM
MH  - Adult
MH  - Caregivers/ethics/psychology
MH  - *Conflict, Psychological
MH  - Decision Making/*ethics
MH  - Humans
MH  - Intensive Care Units/ethics
MH  - *Morals
MH  - Multicenter Studies as Topic
MH  - Narration
MH  - Northern Ireland
MH  - *Nursing Research
MH  - Nursing Staff, Hospital/ethics/psychology
MH  - Physicians/ethics/psychology
MH  - Qualitative Research
MH  - Research Design
MH  - *Stress, Psychological
MH  - Terminal Care/*ethics
OTO - NOTNLM
OT  - doctors and nurses
OT  - end-of-life care
OT  - intensive care
OT  - moral certainty
OT  - moral distress
OT  - narratives
OT  - relatives
EDAT- 2012/12/05 06:00
MHDA- 2013/10/22 06:00
CRDT- 2012/12/05 06:00
PHST- 2012/10/20 00:00 [accepted]
PHST- 2012/12/05 06:00 [entrez]
PHST- 2012/12/05 06:00 [pubmed]
PHST- 2013/10/22 06:00 [medline]
AID - 10.1111/jan.12053 [doi]
PST - ppublish
SO  - J Adv Nurs. 2013 Aug;69(8):1869-80. doi: 10.1111/jan.12053. Epub 2012 Dec 4.


PMID- 23194130
OWN - NLM
STAT- MEDLINE
DCOM- 20130129
LR  - 20161125
IS  - 1464-410X (Electronic)
IS  - 1464-4096 (Linking)
VI  - 110 Suppl 4
DP  - 2012 Dec
TI  - Electrolysis - a new method of renal ablation?
PG  - 77-9
LID - 10.1111/j.1464-410X.2012.11478.x [doi]
AB  - OBJECTIVE: * To present a novel method of renal ablation using direct current
      electrolysis, using a porcine model to assess the safety and efficacy of the
      technique. MATERIALS AND METHODS: * In all, 20 anaesthetised pigs were used,
      after receiving ethical approval. The pigs were housed and managed in accordance 
      with Institute of Medical and Veterinary Science guidelines. * A single 6 F
      catheter incorporating cathode and anode was inserted directly into the renal
      parenchyma via a loin incision. A direct current of 100 mA was applied for
      varying times. * Several treatments were performed in each pig and a total of 72 
      treatments were analysed. * The pigs were recovered and observed for 3 days with 
      an analysis of electrolytes and creatinine after ablation. The pigs were humanely
      killed at 3 days and the kidneys submitted for histological analysis. RESULTS: * 
      Complete tissue destruction was seen in the area of kidney treated with no viable
      cells. * A sharp line of demarcation was noted between normal renal parenchyma
      and the area of coagulative necrosis. The area of tissue ablation was reliably
      predicted from the duration of application of the electrolytic current. * One pig
      developed a secondary haemorrhage. CONCLUSIONS: * Renal electrolysis is a new
      method of focal renal ablation. The procedure may be carried out using a fine
      ablation catheter (6 F) allowing for the development of minimal intervention
      treatment of small renal masses. * This study shows the technique to be effective
      and safe. As with other renal ablative techniques there is a small risk of
      postoperative haemorrhage.
CI  - (c) 2012 THE AUTHORS. BJU INTERNATIONAL (c) 2012 BJU INTERNATIONAL.
FAU - Lloyd, Mark
AU  - Lloyd M
AD  - University of Adelaide, South Australia, Australia. marklloyd@adam.com.au
FAU - Miller, John
AU  - Miller J
FAU - Moretti, Kim L
AU  - Moretti KL
FAU - Texler, Michael
AU  - Texler M
FAU - Maddern, Guy J
AU  - Maddern GJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - BJU Int
JT  - BJU international
JID - 100886721
SB  - IM
MH  - Animals
MH  - Electrolysis/*methods
MH  - Female
MH  - Kidney/pathology/*surgery
MH  - Kidney Neoplasms/*diagnostic imaging
MH  - Neoplasms, Experimental/*surgery
MH  - Swine
MH  - Treatment Outcome
MH  - Ultrasonography
EDAT- 2012/12/05 06:00
MHDA- 2013/01/30 06:00
CRDT- 2012/12/01 06:00
PHST- 2012/12/01 06:00 [entrez]
PHST- 2012/12/05 06:00 [pubmed]
PHST- 2013/01/30 06:00 [medline]
AID - 10.1111/j.1464-410X.2012.11478.x [doi]
PST - ppublish
SO  - BJU Int. 2012 Dec;110 Suppl 4:77-9. doi: 10.1111/j.1464-410X.2012.11478.x.


PMID- 23205356
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121204
LR  - 20211021
IS  - 0973-709X (Electronic)
IS  - 0973-709X (Linking)
VI  - 6
IP  - 8
DP  - 2012 Oct
TI  - Study of the fingertip pattern as a tool for the identification of the
      dermatoglyphic trait in bronchial asthma.
PG  - 1397-400
LID - 10.7860/JCDR/2012/4734.2368 [doi]
AB  - INTRODUCTION: Bronchial Asthma is one of the most extensively studied respiratory
      diseases and its genetic basis is well established. Dermatoglyphic traits are
      formed under genetic control early in development but may be affected by
      environmental factors during first trimester of pregnancy. These patterns may
      represent the genetic makeup of an individual and therefore his/her
      predisposition to certain diseases. Patterns of dermatoglyphics have been studied
      in various congenital disorders like Down's syndrome, Klinefelter's syndrome and 
      also in chronic diseases like Hypertension, Diabetes Mellitus etc. Epidermal
      ridge patterns of finger tips in bronchial asthma patients were studied to find
      out fingertip pattern as Dermatoglyphic features in patients of Bronchial Asthma;
      it's comparison and association if exists between normal and bronchial asthma
      patients and also to find use of fingertip pattern in early childhood as
      non-invasive anatomical marker for bronchial asthma in adulthood. METHODS: The
      study was conducted on clinically diagnosed all bronchial asthma patients
      attending OPD of Dr Ulhas Patil Medical College, Jalgaon. Matched controls were
      selected without any respiratory problem or any symptoms related to asthma from
      medical students, staff members and paramedical staff of hospital after taking
      the informed consent and permission from the institutional ethical committee.
      Data collection and fingertip prints were taken by ink and rolling finger method.
      Prints taken were analysed and tabulated; data was analysed by using statistical 
      tests. RESULTS: Study shows that decrease in number of arches, increase in AFRC
      in patients as compared with controls. Also there were increased ulnar loops in
      male patients and increased Whorls and radial loops in female patients.
      CONCLUSION: The fingerprints can represent a non-invasive anatomical marker of
      bronchial asthma risk and facilitate early detection and effective management
      which is vital for selecting appropriate agents for treating infections.
FAU - Pakhale, Sandeep V
AU  - Pakhale SV
AD  - Associate Professor, Department of Anatomy, Dr. Ulhas Patil Medical College and
      Hospital , Jalgaon (KH), Maharashtra, India.
FAU - Borole, Bharat S
AU  - Borole BS
FAU - Doshi, Megha A
AU  - Doshi MA
FAU - More, Vijay P
AU  - More VP
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Clin Diagn Res
JT  - Journal of clinical and diagnostic research : JCDR
JID - 101488993
PMC - PMC3471507
OTO - NOTNLM
OT  - Bronchial Asthma
OT  - Dermatoglyphics
EDAT- 2012/12/04 06:00
MHDA- 2012/12/04 06:01
CRDT- 2012/12/04 06:00
PHST- 2012/06/20 00:00 [received]
PHST- 2012/07/31 00:00 [accepted]
PHST- 2012/12/04 06:00 [entrez]
PHST- 2012/12/04 06:00 [pubmed]
PHST- 2012/12/04 06:01 [medline]
AID - 10.7860/JCDR/2012/4734.2368 [doi]
PST - ppublish
SO  - J Clin Diagn Res. 2012 Oct;6(8):1397-400. doi: 10.7860/JCDR/2012/4734.2368.


PMID- 23205001
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1615-6609 (Print)
IS  - 1615-6609 (Linking)
VI  - 9
IP  - 1-2
DP  - 2012 Nov
TI  - Ethical aspects of vulnerability in research.
PG  - 157-162
AB  - In connection with research on humans, the term "vulnerability" is only
      appropriate to identify the special need for protection of certain sections of
      the population and individuals, if this term refers to the additional risk of
      certain groups of subjects. Authors who focus on the additional risk suffering of
      a subject group when defining vulnerability succeed in considering the specific
      worthiness of protection in a context-sensitive way. The attempt to define the
      risk-benefit assessment for vulnerable subject groups on a binding basis faces
      considerable difficulties. This assessment depends both on the research situation
      and on the test subject. The normative aspect of this decision could be solved by
      referring to Rawl's decision model of an original position. In cases where there 
      is no benefit for the subject, arguments in the discussion of the risks and
      benefits that are based on a "group or overall benefit" and an "objective
      interest," cannot be fully sustained.
FAU - Weisser-Lohmann, Elisabeth
AU  - Weisser-Lohmann E
AD  - Hagen, Germany.
LA  - eng
PT  - Journal Article
DEP - 20121017
PL  - Germany
TA  - Poiesis Prax
JT  - Poiesis & praxis : international journal of ethics of science and technology
      assessment
JID - 101083157
PMC - PMC3510404
EDAT- 2012/12/04 06:00
MHDA- 2012/12/04 06:01
CRDT- 2012/12/04 06:00
PHST- 2012/12/04 06:00 [entrez]
PHST- 2012/12/04 06:00 [pubmed]
PHST- 2012/12/04 06:01 [medline]
AID - 10.1007/s10202-012-0109-2 [doi]
AID - 109 [pii]
PST - ppublish
SO  - Poiesis Prax. 2012 Nov;9(1-2):157-162. doi: 10.1007/s10202-012-0109-2. Epub 2012 
      Oct 17.


PMID- 23204658
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121204
LR  - 20220317
IS  - 1998-3824 (Electronic)
IS  - 0970-1591 (Linking)
VI  - 28
IP  - 3
DP  - 2012 Jul
TI  - Length of urethra in the Indian adult male population.
PG  - 297-9
LID - 10.4103/0970-1591.102706 [doi]
AB  - OBJECTIVE: The urethral length has not been measured in the Indian population.
      Even the international literature in this arena is very sparse. This paper is an 
      attempt to develop a simple anatomical database for urethral length. MATERIALS
      AND METHODS: Between January 2010 and April 2011, the urethral lengths of 422
      adult male patients who required catheterization as part of regular treatment at 
      our hospital, were recorded after obtaining consent from the patients and from
      the scientific and ethics review boards of the institution. Patients with history
      of prostatic or urethral abnormalities were excluded. The balloon of a sterile
      Foley's catheter was inflated using 10 cc of saline. The length from the junction
      of the balloon to the 'Y' junction of the Foley was measured. The catheter was
      then passed into the bladder and re-inflated to same volume. The penis was gently
      straightened and the length of the catheter outside the penis was measured till
      the premarked point at the 'Y' junction. Subtracting this from the original
      length gave the length of the urethra. RESULTS: The mean length of the urethra
      was 17.55 + 1.42 cm with a range between 14 and 22.5 cm. CONCLUSIONS: Literature 
      in which the length of the normal adult male urethra is recorded for a
      significant sample size is very scarce. Our data adds to basic anatomic
      information of the male urethra specific to the Indian population. STATISTICAL
      METHODS: Descriptive statistical analysis was performed. The non-linear
      regression analysis was employed to find the normative values of urethral length 
      according to age class.
FAU - Krishnamoorthy, Venkatesh
AU  - Krishnamoorthy V
AD  - Department of Urology, NU Hospitals, Bangalore, Karmataka, India.
FAU - Joshi, Praveen B
AU  - Joshi PB
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Urol
JT  - Indian journal of urology : IJU : journal of the Urological Society of India
JID - 8510441
PMC - PMC3507399
OTO - NOTNLM
OT  - Adult urethra
OT  - male urethral anatomy
OT  - urethral length
EDAT- 2012/12/04 06:00
MHDA- 2012/12/04 06:01
CRDT- 2012/12/04 06:00
PHST- 2012/12/04 06:00 [entrez]
PHST- 2012/12/04 06:00 [pubmed]
PHST- 2012/12/04 06:01 [medline]
AID - 10.4103/0970-1591.102706 [doi]
AID - IJU-28-297 [pii]
PST - ppublish
SO  - Indian J Urol. 2012 Jul;28(3):297-9. doi: 10.4103/0970-1591.102706.


PMID- 23204578
OWN - NLM
STAT- MEDLINE
DCOM- 20130121
LR  - 20211021
IS  - 0008-5286 (Print)
IS  - 0008-5286 (Linking)
VI  - 53
IP  - 6
DP  - 2012 Jun
TI  - Veterinary medical ethics. An ethicist's commentary on the treatment of downer
      animals.
PG  - 592, 594
FAU - Rollin, Bernard E
AU  - Rollin BE
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Vet J
JT  - The Canadian veterinary journal = La revue veterinaire canadienne
JID - 0004653
SB  - IM
CIN - Can Vet J. 2012 Nov;53(11):1145. PMID: 23633706
CIN - Can Vet J. 2012 Nov;53(11):1145. PMID: 23633707
MH  - Animal Welfare/*ethics/legislation & jurisprudence
MH  - Animals
MH  - Canada
MH  - Cattle/*injuries
MH  - *Ethics, Clinical
MH  - Euthanasia, Animal
MH  - Humans
MH  - Legislation, Veterinary
MH  - Transportation/*legislation & jurisprudence
MH  - Veterinary Medicine/*ethics
PMC - PMC3354817
EDAT- 2012/12/04 06:00
MHDA- 2013/01/23 06:00
CRDT- 2012/12/04 06:00
PHST- 2012/12/04 06:00 [entrez]
PHST- 2012/12/04 06:00 [pubmed]
PHST- 2013/01/23 06:00 [medline]
PST - ppublish
SO  - Can Vet J. 2012 Jun;53(6):592, 594.


PMID- 23204540
OWN - NLM
STAT- MEDLINE
DCOM- 20130415
LR  - 20220321
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 266
IP  - 3
DP  - 2013 Mar
TI  - Head CT for nontrauma patients in the emergency department: clinical predictors
      of abnormal findings.
PG  - 783-90
LID - 10.1148/radiol.12120732 [doi]
AB  - PURPOSE: To identify predictors of clinically important abnormal findings in
      computed tomography (CT) images of the head among emergency department (ED)
      patients without a history of trauma. MATERIALS AND METHODS: Approval was
      obtained from the institutional research ethics board, and informed consent from 
      patients was not required. This study was a retrospective review of consecutive
      unenhanced head CT examinations in patients aged 18 years or older who did not
      have trauma or known intracranial pathologic processes in ED from January 2004
      through June 2006. Multivariable logistic regression was used to identify
      predictors of clinically important abnormal CT findings in the derivation cohort 
      (CT examinations from January 1, 2004, through August 15, 2005), and the
      reproducibility of findings in a validation cohort (all subsequent CT scans
      through to June 30, 2006) was assessed. The strength of association of each
      variable was expressed with clinically important abnormal CT findings as adjusted
      odds ratio (OR) and 95% confidence interval (CI). RESULTS: Of 29 469 consecutive 
      head CT images performed at a single institution between January 1, 2004, and
      June 30, 2006, 3967 were eligible for this study. Of the CT images in these
      patients, 548 (13.8%) revealed clinically important abnormalities. Six
      independent clinical predictors of important abnormal findings on head CT were
      identified: age (adjusted OR per 10-year increase: 1.17; 95% CI: 1.08, 1.28),
      focal neurologic deficit (adjusted OR: 5.39; 95% CI: 3.90, 7.47), altered mental 
      status (adjusted OR: 2.32; 95% CI: 1.66, 3.25), history of malignancy (adjusted
      OR: 4.11; 95% CI: 2.28, 7.42), nausea and/or vomiting (adjusted OR: 2.22; 95% CI:
      1.14, 4.33), and derangements in coagulation profile (adjusted OR: 1.91; 95% CI: 
      1.07, 3.41). CONCLUSION: This study identified several potential clinical
      predictors of abnormal head CT findings in ED patients who did not sustain
      trauma. Prospective validation of a clinical prediction rule in this population
      is warranted.
FAU - Wang, Xi
AU  - Wang X
AD  - Department of Radiology, McMaster University, 1280 Main St West, Room HSC-2C8,
      Hamilton, ON, Canada L8S 4K1.
FAU - You, John J
AU  - You JJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121130
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
CIN - Radiology. 2013 Aug;268(2):612-3. PMID: 23882102
CIN - Radiology. 2013 Aug;268(2):613. PMID: 24044127
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain Diseases/*diagnostic imaging/*epidemiology
MH  - Comorbidity
MH  - Craniocerebral Trauma/diagnostic imaging/epidemiology
MH  - Female
MH  - Head/*diagnostic imaging
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Nervous System Diseases/*diagnostic imaging/*epidemiology
MH  - Ontario/epidemiology
MH  - Risk Factors
MH  - Tomography, X-Ray Computed/*statistics & numerical data
MH  - Young Adult
EDAT- 2012/12/04 06:00
MHDA- 2013/04/16 06:00
CRDT- 2012/12/04 06:00
PHST- 2012/12/04 06:00 [entrez]
PHST- 2012/12/04 06:00 [pubmed]
PHST- 2013/04/16 06:00 [medline]
AID - radiol.12120732 [pii]
AID - 10.1148/radiol.12120732 [doi]
PST - ppublish
SO  - Radiology. 2013 Mar;266(3):783-90. doi: 10.1148/radiol.12120732. Epub 2012 Nov
      30.


PMID- 23204539
OWN - NLM
STAT- MEDLINE
DCOM- 20130405
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 266
IP  - 2
DP  - 2013 Feb
TI  - Coronary total occlusion lesions: linear intrathrombus enhancement at CT predicts
      better outcome of percutaneous coronary intervention.
PG  - 443-51
LID - 10.1148/radiol.12120961 [doi]
AB  - PURPOSE: To evaluate the presence of linear intrathrombus enhancement in coronary
      total occlusion (CTO) lesions observed at coronary computed tomographic (CT)
      angiography and its correlation with the outcome of percutaneous coronary
      intervention (PCI). MATERIALS AND METHODS: All patients gave written informed
      consent, and the study protocol was approved by the hospital ethics committee.
      Consecutive patients with CTO confirmed at initial conventional coronary
      angiography were prospectively chosen to undergo a coronary CT angiography
      examination prior to their staged PCI. Linear intrathrombus enhancement was
      defined as a linear area of enhanced opacity traversing the nonopacified occluded
      segment with attenuation higher than 120 HU. Angiographic features, including
      lesion length, linear intrathrombus enhancement length, and calcification score, 
      were measured at coronary CT angiography. Univariate and multivariate statistical
      tests were performed to identify variables associated with successful PCI.
      RESULTS: Eighty patients with 88 CTO lesions were included in this study.
      Fifty-one lesions were successfully recanalized at PCI. Lesion length was longer 
      in the PCI failure group (P = .043). Linear intrathrombus enhancement was
      observed in 30 (59%) of the 51 lesions successfully treated with PCI. However,
      linear enhancement was found in seven (19%) of 37 patients with failed PCI (P <
      .001 as compared with patients with successful PCI). Tortuous course was revealed
      to be the only angiographic parameter associated with unfavorable PCI outcome (P 
      = .008). The presence of linear intrathrombus enhancement proved at multivariate 
      analysis to be the only independent predictor of PCI success (odds ratio: 4.926; 
      95% confidence interval: 1.646, 14.74; P = .004). CONCLUSION: The presence of
      coronary CT angiography-visible linear intrathrombus enhancement within the
      occluded segment predicts better outcome of PCI in CTOs.
FAU - Li, Minghua
AU  - Li M
AD  - Department of Radiology, Shanghai No. 6 People's Hospital, School of Medicine,
      Shanghai Jiaotong University, 600 Yishan Rd, Shanghai, China 200233.
FAU - Zhang, Jiayin
AU  - Zhang J
FAU - Pan, Jingwei
AU  - Pan J
FAU - Lu, Zhigang
AU  - Lu Z
LA  - eng
PT  - Journal Article
DEP - 20121130
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - JR13W81H44 (Iopamidol)
SB  - IM
CIN - Rofo. 2013 Aug;185(8):689. PMID: 24058984
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Angioplasty, Balloon, Coronary
MH  - Cardiac-Gated Imaging Techniques
MH  - Contrast Media
MH  - Coronary Angiography
MH  - Coronary Occlusion/*diagnostic imaging/*therapy
MH  - Coronary Thrombosis/*diagnostic imaging/*therapy
MH  - Female
MH  - Humans
MH  - Iopamidol
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - ROC Curve
MH  - Radiographic Image Interpretation, Computer-Assisted
MH  - Statistics, Nonparametric
MH  - Tomography, X-Ray Computed/*methods
MH  - Treatment Outcome
EDAT- 2012/12/04 06:00
MHDA- 2013/04/06 06:00
CRDT- 2012/12/04 06:00
PHST- 2012/12/04 06:00 [entrez]
PHST- 2012/12/04 06:00 [pubmed]
PHST- 2013/04/06 06:00 [medline]
AID - radiol.12120961 [pii]
AID - 10.1148/radiol.12120961 [doi]
PST - ppublish
SO  - Radiology. 2013 Feb;266(2):443-51. doi: 10.1148/radiol.12120961. Epub 2012 Nov
      30.


PMID- 23204324
OWN - NLM
STAT- MEDLINE
DCOM- 20140716
LR  - 20220408
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 9
DP  - 2013 Sep
TI  - Payment of research participants: current practice and policies of Irish research
      ethics committees.
PG  - 591-3
LID - 10.1136/medethics-2012-100679 [doi]
AB  - BACKGROUND: Payment of research participants helps to increase recruitment for
      research studies, but can pose ethical dilemmas. Research ethics committees
      (RECs) have a centrally important role in guiding this practice, but
      standardisation of the ethical approval process in Ireland is lacking. AIM: Our
      aim was to examine REC policies, experiences and concerns with respect to the
      payment of participants in research projects in Ireland. METHOD: Postal survey of
      all RECs in Ireland. RESULTS: Response rate was 62.5% (n=50). 80% of RECs
      reported not to have any established policy on the payment of research subjects
      while 20% had refused ethics approval to studies because the investigators
      proposed to pay research participants. The most commonly cited concerns were the 
      potential for inducement and undermining of voluntary consent. CONCLUSIONS: There
      is considerable variability among RECs on the payment of research participants
      and a lack of clear consensus guidelines on the subject. The development of
      standardised guidelines on the payment of research subjects may enhance
      recruitment of research participants.
FAU - Roche, Eric
AU  - Roche E
AD  - Cluain Mhuire Community Mental Health Service, Dublin, Ireland.
      dr.roche.eric@gmail.com
FAU - King, Romaine
AU  - King R
FAU - Mohan, Helen M
AU  - Mohan HM
FAU - Gavin, Blanaid
AU  - Gavin B
FAU - McNicholas, Fiona
AU  - McNicholas F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121201
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Ethics Committees, Research/*legislation & jurisprudence
MH  - Ethics, Research
MH  - Guidelines as Topic
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Ireland
MH  - Motivation
MH  - Research Subjects/*economics/supply & distribution
OTO - NOTNLM
OT  - Ethics Committees/Consultation
OT  - Policy Guidelines/Inst. Review Boards/Review Cttes.
OT  - Research Ethics
EDAT- 2012/12/04 06:00
MHDA- 2014/07/17 06:00
CRDT- 2012/12/04 06:00
PHST- 2012/12/04 06:00 [entrez]
PHST- 2012/12/04 06:00 [pubmed]
PHST- 2014/07/17 06:00 [medline]
AID - medethics-2012-100679 [pii]
AID - 10.1136/medethics-2012-100679 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Sep;39(9):591-3. doi: 10.1136/medethics-2012-100679. Epub 2012
      Dec 1.


PMID- 23204319
OWN - NLM
STAT- MEDLINE
DCOM- 20130325
LR  - 20130121
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 2
DP  - 2013 Feb
TI  - Internet-based crowdsourcing and research ethics: the case for IRB review.
PG  - 115-8
LID - 10.1136/medethics-2012-100798 [doi]
AB  - The recent success of Foldit in determining the structure of the Mason-Pfizer
      monkey virus (M-PMV) retroviral protease is suggestive of the power-solving
      potential of internet-facilitated game-like crowdsourcing. This research model is
      highly novel, however, and thus, deserves careful consideration of potential
      ethical issues. In this paper, we will demonstrate that the crowdsourcing model
      of research has the potential to cause harm to participants, manipulates the
      participant into continued participation, and uses participants as experimental
      subjects. We conclude that protocols relying on this model require institutional 
      review board (IRB) scrutiny.
FAU - Graber, Mark A
AU  - Graber MA
AD  - Department of Emergency Medicine, University of Iowa Carver College of Medicine, 
      Iowa City, Iowa 52242, USA. mark-graber@uiowa.edu
FAU - Graber, Abraham
AU  - Graber A
LA  - eng
PT  - Journal Article
DEP - 20121130
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
RN  - 0 (Retroviridae Proteins)
RN  - EC 3.4.- (Peptide Hydrolases)
SB  - IM
MH  - Behavior, Addictive/etiology
MH  - Crowdsourcing/*ethics/methods
MH  - *Ethics Committees, Research
MH  - *Ethics, Research
MH  - *Games, Experimental
MH  - Humans
MH  - *Informed Consent
MH  - *Internet
MH  - Mason-Pfizer monkey virus/enzymology
MH  - Peptide Hydrolases/chemistry
MH  - Protein Folding
MH  - *Research Design
MH  - *Research Personnel/psychology
MH  - *Research Subjects/psychology
MH  - Retroviridae Proteins/chemistry
EDAT- 2012/12/04 06:00
MHDA- 2013/03/26 06:00
CRDT- 2012/12/04 06:00
PHST- 2012/12/04 06:00 [entrez]
PHST- 2012/12/04 06:00 [pubmed]
PHST- 2013/03/26 06:00 [medline]
AID - medethics-2012-100798 [pii]
AID - 10.1136/medethics-2012-100798 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Feb;39(2):115-8. doi: 10.1136/medethics-2012-100798. Epub 2012
      Nov 30.


PMID- 23204141
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130207
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 6
DP  - 2012
TI  - A cross-sectional study of the appropriateness of colonoscopy requests in the
      Spanish region of Catalonia.
LID - 10.1136/bmjopen-2012-002207 [doi]
LID - e002207 [pii]
AB  - INTRODUCTION: Colonoscopies are being requested with increasing frequency in the 
      last few years, as they are used both as a diagnostic and therapeutic procedure
      in several gastrointestinal diseases. Our purpose is to describe the
      appropriateness of colonoscopy requests issued both from primary care centres and
      from hospitals, according to the EPAGE II guidelines (European Panel on the
      Appropriateness of Gastrointestinal Endoscopy). METHODS AND ANALYSIS:
      Cross-sectional study. Colonoscopy requests issued since January 2011 and
      received at the endoscopy units of all six reference hospitals serving the
      primary care centres of the South Metropolitan and Central Catalonia districts
      will be collected (total=1500 requests). Variables to be collected include
      gender, date of birth, origin of the request and reference hospital, priority of 
      the procedure, type of clinician requesting the procedure, date and indication of
      request, abdominal examination performed, anal inspection examination performed, 
      date of last colonoscopy if applicable, diagnosis and date of diagnosis. Using
      the available information and the EPAGE II website, colonoscopy requests will be 
      assigned as an appropriateness score. The association between the variables
      collected and the EPAGE II scores will be assessed using a Student's t test and a
      chi(2) test. A multilevel logistic model will be generated on the factors
      associated with the appropriateness of the requests. ETHICS AND DISSEMINATION:
      Colonoscopy is a costly procedure and not free from complications. In order to
      increase cost effectiveness, reduce waiting lists and optimise resources, it is
      necessary to use tools such as the EPAGE II guidelines, which establish criteria 
      to assess the appropriateness of colonoscopies. The purpose of this study is to
      describe the current situation and to discuss whether current clinical practice
      is appropriate. The results of the study will be published in the next few years.
      In consideration of the ethical principles and methods of the research study,
      approval was granted for the project.
FAU - Puente, Diana
AU  - Puente D
AD  - Institut Universitari d'Investigacio en Atencio Primaria Jordi Gol (IDIAP Jordi
      Gol), Barcelona, Spain.
FAU - Cantero, Francesc Xavier
AU  - Cantero FX
FAU - Llagostera, Maria
AU  - Llagostera M
FAU - Pineiro, Pilar
AU  - Pineiro P
FAU - Nieto, Raquel
AU  - Nieto R
FAU - Saladich, Rosa
AU  - Saladich R
FAU - Mascort, Juanjo
AU  - Mascort J
FAU - Marzo, Merce
AU  - Marzo M
FAU - Almeda, Jesus
AU  - Almeda J
FAU - Segarra, Manel
AU  - Segarra M
CN  - CANCER-REAP Research Group
LA  - eng
PT  - Journal Article
DEP - 20121130
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3533100
EDAT- 2012/12/04 06:00
MHDA- 2012/12/04 06:01
CRDT- 2012/12/04 06:00
PHST- 2012/12/04 06:00 [entrez]
PHST- 2012/12/04 06:00 [pubmed]
PHST- 2012/12/04 06:01 [medline]
AID - bmjopen-2012-002207 [pii]
AID - 10.1136/bmjopen-2012-002207 [doi]
PST - epublish
SO  - BMJ Open. 2012 Nov 30;2(6). pii: bmjopen-2012-002207. doi:
      10.1136/bmjopen-2012-002207. Print 2012.


PMID- 23204076
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121204
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 6
DP  - 2012
TI  - Patients' silence towards the healthcare system after ethical transgressions by
      staff: associations with patient characteristics in a cross-sectional study among
      Swedish female patients.
LID - 10.1136/bmjopen-2012-001562 [doi]
LID - e001562 [pii]
AB  - OBJECTIVES: To identify which patient characteristics are associated with silence
      towards the healthcare system after experiences of abusive or ethically wrongful 
      transgressive behaviour by healthcare staff. DESIGN: Cross-sectional
      questionnaire study using the Transgressions of Ethical Principles in Health Care
      Questionnaire. SETTING: A women's clinic in the south of Sweden. PARTICIPANTS:
      Selection criteria were: consecutive female patients coming for an outpatient
      appointment, >/=18-year-old, with the ability to speak and understand the Swedish
      language, and a known address. Questionnaires were answered by 534 women (60%)
      who had visited the clinic, of which 293 were included in the present study
      sample. PRIMARY OUTCOME MEASURE: How many times the respondent remained silent
      towards the healthcare system relative to the number of times the respondent
      spoke up. RESULTS: Associations were found between patients' silence towards the 
      healthcare system and young age as well as lower self-rated knowledge of patient 
      rights. Both variables showed independent effects on patients' silence in a
      multivariate model. No associations were found with social status, country of
      birth, health or other abuse. CONCLUSIONS: The results offer opportunities for
      designing interventions to stimulate patients to speak up and open up the
      clinical climate, for which the responsibility lies in the hands of staff; but
      more research is needed.
FAU - Bruggemann, A Jelmer
AU  - Bruggemann AJ
AD  - Gender and Medicine, Department of Clinical and Experimental Medicine, Linkoping 
      University, Linkoping, Sweden.
FAU - Swahnberg, Katarina
AU  - Swahnberg K
LA  - eng
PT  - Journal Article
DEP - 20121129
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3532985
EDAT- 2012/12/04 06:00
MHDA- 2012/12/04 06:01
CRDT- 2012/12/04 06:00
PHST- 2012/12/04 06:00 [entrez]
PHST- 2012/12/04 06:00 [pubmed]
PHST- 2012/12/04 06:01 [medline]
AID - bmjopen-2012-001562 [pii]
AID - 10.1136/bmjopen-2012-001562 [doi]
PST - epublish
SO  - BMJ Open. 2012 Nov 29;2(6). pii: bmjopen-2012-001562. doi:
      10.1136/bmjopen-2012-001562. Print 2012.


PMID- 23202992
OWN - NLM
STAT- MEDLINE
DCOM- 20130725
LR  - 20130116
IS  - 1460-2350 (Electronic)
IS  - 0268-1161 (Linking)
VI  - 28
IP  - 2
DP  - 2013 Feb
TI  - Uterine transplantation--a real possibility? The Indianapolis consensus.
PG  - 288-91
LID - 10.1093/humrep/des406 [doi]
AB  - A group of experts gathered in Indianapolis in December 2011 to address lingering
      concerns related to uterus transplantation (UTn). They represent a multi-national
      group of four research teams who have worked for over 15 years on bringing UTn to
      reality for patients. Presented here are a set of parameters that must be
      considered in order for UTn to become an acceptable procedure in the human
      setting. UTn has been proposed as a potential solution to absolute uterine factor
      infertility (AUFI). Causes of AUFI include congenital uterine factors (i.e.
      absence or malformation) or acquired uterine factors (e.g. hysterectomy for
      uncontrollable hemorrhage) rendering a woman 'unconditionally infertile'. Current
      estimates are that in the USA, up to 7 million women with AUFI may be appropriate
      candidates for UTn. As a result of a first human attempt in 2000, investigators
      have responded with a plethora of publications demonstrating successful UTn
      attempts, including pregnancies, in various autogeneic, syngeneic and allogeneic 
      animal models. Before UTn can become an accepted procedure, it must satisfy
      defined criteria for any surgical innovation, i.e. research background, field
      strength and institutional stability. Equally important, UTn must satisfy
      accepted bioethical principles (respect for autonomy, beneficence,
      non-maleficence and justice) and their application (informed consent, appropriate
      assessment of risk and benefit and fair selection of individuals). Furthermore,
      we believe that a defined number of transplants should not be exceeded worldwide 
      without a successful term delivery, to minimize proceeding in futility using
      current techniques. Even if UTns were to become relatively common, the following 
      research objectives should be continuously pursued: (i) additional pregnancies in
      a variety of large animal/primate models (to search for unanticipated
      consequences), (ii) continuous assessment of women diagnosed with AUFI regarding 
      UTn, (iii) continuous assessment using 'borrowed' psychological tools from
      transplant centers, adoption agencies and assisted reproductive technology
      centers with potential recipients and (iv) continuous careful ethical reflection,
      assessment and approval.
FAU - Del Priore, Giuseppe
AU  - Del Priore G
AD  - Mel and Breen Simon Cancer Center, Department of Obstetrics and Gynecology,
      Indiana University School of Medicine, Indiana University, Indianapolis, USA.
      gdelprio@iupui.edu
FAU - Saso, Srdjan
AU  - Saso S
FAU - Meslin, Eric M
AU  - Meslin EM
FAU - Tzakis, Andreas
AU  - Tzakis A
FAU - Brannstrom, Mats
AU  - Brannstrom M
FAU - Clarke, Alex
AU  - Clarke A
FAU - Vianna, Rodrigo
AU  - Vianna R
FAU - Sawyer, Renata
AU  - Sawyer R
FAU - Smith, J Richard
AU  - Smith JR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121130
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
SB  - IM
CIN - Hum Reprod. 2013 Feb;28(2):292-3. PMID: 23202991
MH  - Consensus
MH  - Female
MH  - Humans
MH  - Infertility, Female/*surgery
MH  - Organ Transplantation/ethics/psychology
MH  - Reproductive Techniques, Assisted/ethics/psychology
MH  - United States
MH  - Uterus/*transplantation
EDAT- 2012/12/04 06:00
MHDA- 2013/07/26 06:00
CRDT- 2012/12/04 06:00
PHST- 2012/12/04 06:00 [entrez]
PHST- 2012/12/04 06:00 [pubmed]
PHST- 2013/07/26 06:00 [medline]
AID - des406 [pii]
AID - 10.1093/humrep/des406 [doi]
PST - ppublish
SO  - Hum Reprod. 2013 Feb;28(2):288-91. doi: 10.1093/humrep/des406. Epub 2012 Nov 30.


PMID- 23202991
OWN - NLM
STAT- MEDLINE
DCOM- 20130725
LR  - 20181202
IS  - 1460-2350 (Electronic)
IS  - 0268-1161 (Linking)
VI  - 28
IP  - 2
DP  - 2013 Feb
TI  - Uterus transplantation in the human: a complex surgical, medical and ethical
      challenge.
PG  - 292-3
LID - 10.1093/humrep/des407 [doi]
FAU - Brosens, Ivo
AU  - Brosens I
AD  - Catholic University Leuven, Leuven, Belgium. ivo.brosens@med.kuleuven.ac.be
FAU - Ghaem-Maghami, Sadaf
AU  - Ghaem-Maghami S
FAU - Pijnenborg, Robert
AU  - Pijnenborg R
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20121130
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
SB  - IM
CON - Hum Reprod. 2013 Feb;28(2):288-91. PMID: 23202992
MH  - Female
MH  - Humans
MH  - Infertility, Female/*surgery
MH  - Uterus/*transplantation
EDAT- 2012/12/04 06:00
MHDA- 2013/07/26 06:00
CRDT- 2012/12/04 06:00
PHST- 2012/12/04 06:00 [entrez]
PHST- 2012/12/04 06:00 [pubmed]
PHST- 2013/07/26 06:00 [medline]
AID - des407 [pii]
AID - 10.1093/humrep/des407 [doi]
PST - ppublish
SO  - Hum Reprod. 2013 Feb;28(2):292-3. doi: 10.1093/humrep/des407. Epub 2012 Nov 30.


PMID- 23201097
OWN - NLM
STAT- MEDLINE
DCOM- 20130325
LR  - 20131022
IS  - 1090-2430 (Electronic)
IS  - 0014-4886 (Linking)
VI  - 240
DP  - 2013 Feb
TI  - Experimental and clinical factors influencing long-term stable in vitro expansion
      of multipotent neural cells from human adult temporal lobes.
PG  - 168-77
LID - 10.1016/j.expneurol.2012.11.021 [doi]
LID - S0014-4886(12)00438-4 [pii]
AB  - Autologous adult human neural stem cells may be used for regenerative cell
      therapies bypass potential ethical problems. However, stable in vitro expansion
      protocols and experimental/clinical factors influencing primary cultures need to 
      be further elucidated for clinically applicable techniques. To address these
      issues, we obtained biopsy specimens from 23 temporal lobe epilepsy patients and 
      adult human multipotent neural cells (ahMNCs) were primarily cultured in a
      defined attachment culture condition. When the success of primary cultures was
      defined as stable expansion of cells (>ten in vitro passages) and expression of
      NSC markers, success rate of the primary culture was 39% (nine of 23 temporal
      lobes). During the long-term expansion, expressions of NSC markers and
      differentiation potentials into astrocytes and neurons were maintained. After the
      18th sub-culture, spontaneous senescence and differentiation were observed, and
      the cultivated ahMNCs ceased their proliferation. The culture results were not
      affected by seizure characteristics; however, an older age (>40 years) and a
      smaller sample volume (<2 ml) were found to exert negative influences on the
      primary culture results. Furthermore therapeutic effects of ahMNCs against stroke
      were analyzed in an animal model. Transplantation of ahMNCs cells reduced
      infarction volumes and enhanced motor activity, significantly. The results here
      would provide promising experimental and clinical strategy of using
      patient-specific autologous ahMNCs in regenerative medicine in the future.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Joo, Kyeung Min
AU  - Joo KM
AD  - Department of Anatomy and Cell Biology, Sungkyunkwan University School of
      Medicine, Samsung Biomedical Research Institute, #300 Cheoncheon-dong, Jangan-gu,
      Suwon, Gyeonggi-do, 440-746, South Korea.
FAU - Kang, Bong Gu
AU  - Kang BG
FAU - Yeon, Je Young
AU  - Yeon JY
FAU - Cho, Yu Jin
AU  - Cho YJ
FAU - An, Jae Yeol
AU  - An JY
FAU - Song, Hyeon Suk
AU  - Song HS
FAU - Won, Jun Ho
AU  - Won JH
FAU - Kim, Sang Jeong
AU  - Kim SJ
FAU - Hong, Seung-Chyul
AU  - Hong SC
FAU - Nam, Do-Hyun
AU  - Nam DH
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121129
PL  - United States
TA  - Exp Neurol
JT  - Experimental neurology
JID - 0370712
SB  - IM
EIN - Exp Neurol. 2013 Sep;247:748
MH  - Adolescent
MH  - Adult
MH  - Adult Stem Cells/*cytology/transplantation
MH  - Animals
MH  - Child
MH  - Disease Models, Animal
MH  - Epilepsy, Temporal Lobe/*physiopathology
MH  - Female
MH  - Humans
MH  - Infarction, Middle Cerebral Artery/*therapy
MH  - Male
MH  - Middle Aged
MH  - Multipotent Stem Cells/*cytology/transplantation
MH  - Neural Stem Cells/*cytology/transplantation
MH  - Primary Cell Culture/methods
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Temporal Lobe/*cytology
MH  - Young Adult
EDAT- 2012/12/04 06:00
MHDA- 2013/03/26 06:00
CRDT- 2012/12/04 06:00
PHST- 2012/06/28 00:00 [received]
PHST- 2012/11/17 00:00 [revised]
PHST- 2012/11/21 00:00 [accepted]
PHST- 2012/12/04 06:00 [entrez]
PHST- 2012/12/04 06:00 [pubmed]
PHST- 2013/03/26 06:00 [medline]
AID - S0014-4886(12)00438-4 [pii]
AID - 10.1016/j.expneurol.2012.11.021 [doi]
PST - ppublish
SO  - Exp Neurol. 2013 Feb;240:168-77. doi: 10.1016/j.expneurol.2012.11.021. Epub 2012 
      Nov 29.


PMID- 23200916
OWN - NLM
STAT- MEDLINE
DCOM- 20130325
LR  - 20220330
IS  - 1095-6859 (Electronic)
IS  - 0090-8258 (Linking)
VI  - 128
IP  - 2
DP  - 2013 Feb
TI  - MRI, PET/CT and ultrasound in the preoperative staging of endometrial cancer - a 
      multicenter prospective comparative study.
PG  - 300-8
LID - 10.1016/j.ygyno.2012.11.025 [doi]
LID - S0090-8258(12)00891-8 [pii]
AB  - OBJECTIVES: The aim of this prospective multicenter study was to evaluate and
      compare the diagnostic performance of PET/CT, MRI and transvaginal
      two-dimensional ultrasound (2DUS) in the preoperative assessment of endometrial
      cancer (EC). METHODS: 318 consecutive women with EC were included when referred
      to three Danish tertiary gynecological centers for surgical treatment.
      Preoperatively they were PET/CT-, MRI-, and 2DUS scanned. The imaging results
      were compared to the final pathological findings. This study was approved by the 
      National Committee on Health Research Ethics. RESULTS: For predicting myometrial 
      invasion, we found sensitivity, specificity, PPV, NPV, and accuracy for PET/CT to
      be 93%, 49%, 41%, 95% and 61%, for MRI to be 87%, 57%, 44%, 92%, and 66% and for 
      2DUS to be 71%, 72%, 51%, 86% and 72%. For predicting cervical invasion, the
      values were 43%, 94%, 69%, 85% and 83%, respectively, for PET/CT, 33%, 95%, 60%, 
      85%, and 82%, respectively, for MRI, and 29%, 92%, 48%, 82% and 78% for 2DUS.
      Finally, for lymph node metastases, the values were 74%, 93%, 59%, 96%, and 91%
      for PET/CT and 59%, 93%, 40%, 97% and 90% for MRI. When comparing the diagnostic 
      performance we found PET/CT, MRI and 2DUS to be comparable in predicting
      myometrial invasion. For cervical invasion and lymph node metastases, however,
      PET/CT was the best. CONCLUSIONS: None of the modalities can yet replace surgical
      staging. However, they all contributed to important knowledge and were,
      furthermore, able to upstage low-risk patients who would not have been
      recommended lymph node resection based on histology and grade alone.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Antonsen, Sofie Leisby
AU  - Antonsen SL
AD  - Gynecologic Clinic, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej
      9, 2100 Copenhagen O, Denmark. Sleisby@dadlnet.dk
FAU - Jensen, Lisa Neerup
AU  - Jensen LN
FAU - Loft, Annika
AU  - Loft A
FAU - Berthelsen, Anne Kiil
AU  - Berthelsen AK
FAU - Costa, Junia
AU  - Costa J
FAU - Tabor, Ann
AU  - Tabor A
FAU - Qvist, Ingelise
AU  - Qvist I
FAU - Hansen, Mette Rodi
AU  - Hansen MR
FAU - Fisker, Rune
AU  - Fisker R
FAU - Andersen, Erik Sogaard
AU  - Andersen ES
FAU - Sperling, Lene
AU  - Sperling L
FAU - Nielsen, Anne Lerberg
AU  - Nielsen AL
FAU - Asmussen, Jon
AU  - Asmussen J
FAU - Hogdall, Estrid
AU  - Hogdall E
FAU - Fago-Olsen, Carsten L
AU  - Fago-Olsen CL
FAU - Christensen, Ib Jarle
AU  - Christensen IJ
FAU - Nedergaard, Lotte
AU  - Nedergaard L
FAU - Jochumsen, Kirsten
AU  - Jochumsen K
FAU - Hogdall, Claus
AU  - Hogdall C
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20121128
PL  - United States
TA  - Gynecol Oncol
JT  - Gynecologic oncology
JID - 0365304
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Endometrial Neoplasms/diagnostic imaging/*pathology/surgery
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Middle Aged
MH  - Multimodal Imaging
MH  - Neoplasm Staging
MH  - Positron-Emission Tomography
MH  - Prospective Studies
MH  - Tomography, X-Ray Computed
MH  - Ultrasonography/methods
MH  - Vagina/diagnostic imaging
EDAT- 2012/12/04 06:00
MHDA- 2013/03/26 06:00
CRDT- 2012/12/04 06:00
PHST- 2012/09/19 00:00 [received]
PHST- 2012/11/14 00:00 [revised]
PHST- 2012/11/17 00:00 [accepted]
PHST- 2012/12/04 06:00 [entrez]
PHST- 2012/12/04 06:00 [pubmed]
PHST- 2013/03/26 06:00 [medline]
AID - S0090-8258(12)00891-8 [pii]
AID - 10.1016/j.ygyno.2012.11.025 [doi]
PST - ppublish
SO  - Gynecol Oncol. 2013 Feb;128(2):300-8. doi: 10.1016/j.ygyno.2012.11.025. Epub 2012
      Nov 28.


PMID- 23200886
OWN - NLM
STAT- MEDLINE
DCOM- 20150930
LR  - 20130923
IS  - 1532-2793 (Electronic)
IS  - 0260-6917 (Linking)
VI  - 33
IP  - 11
DP  - 2013 Nov
TI  - The ethical considerations associated with group work assessments.
PG  - 1422-7
LID - 10.1016/j.nedt.2012.11.006 [doi]
LID - S0260-6917(12)00379-6 [pii]
AB  - Assessments that require students to participate in group work are incorporated
      throughout programmes in Higher Education Institutions. Ethical dimensions are
      integral to all assessments including assessments that require students to
      participate in group work. Assessments should be fair and consideration needs to 
      be given to preparing students and lecturers to undertake group work. Decisions
      such as group selection and allocation of marks for group assessments are
      important areas that will influence the outcome of group work assessments. The
      following article explores the above issues and identifies action points for
      optimising group work.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Noonan, Maria
AU  - Noonan M
AD  - Department of Nursing and Midwifery, Health Science Building, North Bank Campus, 
      University of Limerick, Limerick, Ireland. Electronic address:
      maria.noonan@ul.ie.
LA  - eng
PT  - Journal Article
DEP - 20121130
PL  - Scotland
TA  - Nurse Educ Today
JT  - Nurse education today
JID - 8511379
MH  - Attitude of Health Personnel
MH  - *Choice Behavior
MH  - Education, Nursing/*ethics
MH  - Educational Measurement
MH  - *Ethics, Nursing
MH  - *Group Processes
MH  - Guidelines as Topic
MH  - Humans
MH  - Nursing Education Research
MH  - Students, Nursing/*psychology
OTO - NOTNLM
OT  - Ethical issues
OT  - Group work
OT  - Peer assessment
EDAT- 2012/12/04 06:00
MHDA- 2015/10/01 06:00
CRDT- 2012/12/04 06:00
PHST- 2012/08/17 00:00 [received]
PHST- 2012/11/14 00:00 [accepted]
PHST- 2012/12/04 06:00 [entrez]
PHST- 2012/12/04 06:00 [pubmed]
PHST- 2015/10/01 06:00 [medline]
AID - S0260-6917(12)00379-6 [pii]
AID - 10.1016/j.nedt.2012.11.006 [doi]
PST - ppublish
SO  - Nurse Educ Today. 2013 Nov;33(11):1422-7. doi: 10.1016/j.nedt.2012.11.006. Epub
      2012 Nov 30.


PMID- 23200701
OWN - NLM
STAT- MEDLINE
DCOM- 20130930
LR  - 20161125
IS  - 1878-0946 (Electronic)
IS  - 1744-165X (Linking)
VI  - 18
IP  - 2
DP  - 2013 Apr
TI  - Ethical considerations in neonatal end-of-life care.
PG  - 105-10
LID - 10.1016/j.siny.2012.10.011 [doi]
LID - S1744-165X(12)00130-8 [pii]
AB  - Decisions regarding the end-of-life care of neonates, especially those at the
      limits of viability, cannot be made on the basis of clinical facts alone. They
      should take into account the values and beliefs of all concerned. Application of 
      classical moral theories may take insufficient account of the interests of small 
      babies. Due consideration needs to be given to the value and quality of babies'
      lives, their best interests, and the interests of their parents in practical
      decision-making. Life-sustaining treatments can be withheld or withdrawn if they 
      no longer serve the baby's best interests, but active euthanasia (though an
      acceptable practice in The Netherlands) remains illegal in the UK. Withdrawal of 
      clinically assisted nutrition and hydration can be ethical but remains
      controversial. If organ donation in UK neonates is to become established it will 
      need to respond to the changing characteristics of neonatal deaths in ways that
      are ethically and socially sensitive.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Larcher, Vic
AU  - Larcher V
AD  - Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, UK.
      victor.larcher@gosh.nhs.uk
LA  - eng
PT  - Journal Article
DEP - 20121129
PL  - Netherlands
TA  - Semin Fetal Neonatal Med
JT  - Seminars in fetal & neonatal medicine
JID - 101240003
SB  - IM
MH  - Decision Making/*ethics
MH  - Humans
MH  - Infant, Newborn
MH  - Intensive Care Units, Neonatal
MH  - Palliative Care/*ethics
MH  - Terminal Care/*ethics
MH  - United Kingdom
MH  - Withholding Treatment/*ethics
EDAT- 2012/12/04 06:00
MHDA- 2013/10/01 06:00
CRDT- 2012/12/04 06:00
PHST- 2012/12/04 06:00 [entrez]
PHST- 2012/12/04 06:00 [pubmed]
PHST- 2013/10/01 06:00 [medline]
AID - S1744-165X(12)00130-8 [pii]
AID - 10.1016/j.siny.2012.10.011 [doi]
PST - ppublish
SO  - Semin Fetal Neonatal Med. 2013 Apr;18(2):105-10. doi: 10.1016/j.siny.2012.10.011.
      Epub 2012 Nov 29.


PMID- 23200617
OWN - NLM
STAT- MEDLINE
DCOM- 20130604
LR  - 20121203
IS  - 0013-7006 (Print)
IS  - 0013-7006 (Linking)
VI  - 38
IP  - 6
DP  - 2012 Dec
TI  - [Psychodynamic and forensic approach of constitutional mythomania: a case
      report].
PG  - 504-11
LID - 10.1016/j.encep.2012.01.005 [doi]
LID - S0013-7006(12)00006-1 [pii]
AB  - INTRODUCTION: Constitutional mythomania presents several diagnostic,
      aetiopathogenic and forensic problems for the doctor. We have discussed these
      aspects through the analysis of a case report. CASE REPORT: The case report
      relates to a 43 year-old man, who was subjected to a penal expertise following
      the emission of cheques without provision. During the examination, he pretended
      being both a doctor and a lawyer at the same time. He was in charge, among other 
      things, of sale contracts dealing sometimes with high value transactions,
      obviously without following the required legal procedure. He was pursued
      subsequently for many other affairs of swindle. Data collected from his medical
      file indicated that he was the only boy of his family. Since his father had
      suffered from psychotic episodes, his grandfather had reared him; which he did it
      in a strictly religious way. He spent his childhood isolated. He was 15 years old
      when his grandfather died. He had then expressed religious and megalomaniac ideas
      that had motivated psychiatric management. Later on, he expressed imaginative
      ideas evoking unsystematized delusion (he pretended to have made a trip to
      America and to have seen a fish flying and turning into a woman). DISCUSSION:
      From a psychodynamic point of view, constitutional mythomania is considered as a 
      borderline personality. It reflects an important narcissisic cleavage. The
      deceitfulness of the mythomaniac allows him to keep in touch with reality and to 
      avoid mental disintegration. The recognition, by others, of these delusions
      allows the mythomaniac to have access to his proper level of existence. For a
      while, to the experts our patient appeared to be suffering from schizophrenia.
      Therefore, we can apply the Maleval theory to him, which identifies four periods 
      as delusion structuring levels in psychosis : P0 (consequence of the phallic
      signification deficiency, it includes anxiety, annihilation, perplexity,
      interrogative attitude), P1 (stage of paranoid delusion), P2 (stage of paranoiac 
      delusion) and P3 (ambitious stage evoking paraphrenia and squaring with
      mythomaniac behaviour). According to the Maleval theory, our patient would have
      experimented a repetitive cycle: he tried to escape instable and anxious
      positions (P0, P1) by committing sacrificial acting out (offence), or by reaching
      stable positions which are P2 and P3. The mythomaniac behaviour would appear
      during the latest period. The delusional decompensation would indicate a return
      to the first two periods. On the other hand, the personal myth might be seen as
      the result of the failure of the assimilation of actual experiences. Several
      psychoanalysts consider the use of myths by some psychotics as an attempt to
      reduce their ego disintegration. The mythomaniac may create his own myth in order
      to reduce the psychotic anxiety. The personal myth does not represent the pain of
      the patient but his remedy against his disorders. Therefore, identifying a
      personal myth may help the psychotic to turn his delusion into supportable logic 
      of life. Myth may also be used in less deep pathologies such as borderline
      context, where it dominates the clinical picture. CONCLUSION: On the forensic
      level, we could a priori postulate that the mythomaniac sufficiently perceives
      reality to be considered as lucid. In fact, he hardly masters the totality of his
      intentions, being guided by an irrepressible mechanism that makes mythomania a
      "serious" and handicapping illness; its prima victim being the patient
      him/herself. No measures could actually prevent the latter from infringing the
      law, except, perhaps, a permanent administrative control; but this would not be
      without practical and ethical problems.
CI  - Copyright (c) 2012 L'Encephale, Paris. Published by Elsevier Masson SAS. All
      rights reserved.
FAU - Ben Thabet, J
AU  - Ben Thabet J
AD  - Service de psychiatrie C, faculte de medecine de Sfax, universite de Sfax, CHU
      Hedi-Chaker, route El-Ain-km 1, 3029 Sfax, Tunisie. kamounjihene@yahoo.fr
FAU - Zouari, N
AU  - Zouari N
FAU - Charfeddine, F
AU  - Charfeddine F
FAU - Zouari, L
AU  - Zouari L
FAU - Maalej, M
AU  - Maalej M
LA  - fre
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - Approche psychodynamique et medicolegale de la mythomanie constitutionnelle: a
      propos d'une observation.
DEP - 20120531
PL  - France
TA  - Encephale
JT  - L'Encephale
JID - 7505643
SB  - IM
MH  - Acting Out
MH  - Adult
MH  - Anxiety Disorders/diagnosis/psychology
MH  - Borderline Personality Disorder/diagnosis/*psychology
MH  - Compulsive Behavior/diagnosis/*psychology
MH  - *Deception
MH  - Delusions/diagnosis/psychology
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Expert Testimony/*legislation & jurisprudence
MH  - France
MH  - Fraud/*legislation & jurisprudence/*psychology
MH  - Humans
MH  - Male
MH  - Narcissism
MH  - *Psychoanalytic Theory
MH  - Psychopathology
MH  - Reality Testing
MH  - Schizophrenia/diagnosis/genetics
MH  - Schizophrenic Psychology
EDAT- 2012/12/04 06:00
MHDA- 2013/06/05 06:00
CRDT- 2012/12/04 06:00
PHST- 2010/08/04 00:00 [received]
PHST- 2011/10/19 00:00 [accepted]
PHST- 2012/12/04 06:00 [entrez]
PHST- 2012/12/04 06:00 [pubmed]
PHST- 2013/06/05 06:00 [medline]
AID - S0013-7006(12)00006-1 [pii]
AID - 10.1016/j.encep.2012.01.005 [doi]
PST - ppublish
SO  - Encephale. 2012 Dec;38(6):504-11. doi: 10.1016/j.encep.2012.01.005. Epub 2012 May
      31.


PMID- 23200612
OWN - NLM
STAT- MEDLINE
DCOM- 20130604
LR  - 20151119
IS  - 0013-7006 (Print)
IS  - 0013-7006 (Linking)
VI  - 38
IP  - 6
DP  - 2012 Dec
TI  - [Chemical and behavioural addiction of medical students. Comparative study in
      Lebanese students].
PG  - 467-72
LID - 10.1016/j.encep.2011.12.010 [doi]
LID - S0013-7006(11)00235-1 [pii]
AB  - OBJECTIVE: Evaluate chemical and behavioural dependence of medical students, and 
      compare it to a control group (students in non-medical faculties), in order to
      underline the harmful effect of university on medical students' dependence.
      METHODS: A three-part questionnaire was distributed to a sample of 140 medical
      students at the Saint-Joseph university of Beirut (USJ), and to 140 students in
      many other USJ faculties, and filled in anonymously. The first part is about
      demographic criteria and the second and third parts are respectively about
      chemical and behavioural dependence, based on DSM IV criteria. RESULTS: There is 
      no statistically significant difference between the two studied populations
      concerning the dependence on alcohol, cannabis, sedatives, opiates, amphetamines,
      workaholism, gambling and Internet. However, the prevalence of addiction to
      caffeine, cocaine, nicotine; sexual addiction, and compulsive buying are
      significantly lower in medical students when compared to the control group. Men, 
      compared to women, did not show significantly higher levels of dependence on
      chemical substances. Workaholism is not significantly more prevalent in women.
      Sexual addiction and compulsive buying are not significantly higher in men.
      However, pathological gambling and Internet addiction are significantly more
      prevalent in men. Finally, this study does not show a variation in dependence
      through the years of medical studies. DISCUSSION: Most studies show that medical 
      students have high levels of dependence on alcohol, opiates and sedatives. The
      results of our study show greater dependence on caffeine followed by nicotine,
      alcohol and sedatives. Medical students in our population did not reveal higher
      dependence rates compared to other university students. Overall, substance
      addiction in medical students may be related to the stress of medical studies,
      and easy access to drugs and prescriptions. These factors may be balanced by
      perfectionist traits, ethical standards and knowledge of adverse effects seen in 
      medical students resulting in more adjusted prevalence of addiction when compared
      to other university students. CONCLUSION: The prevalence of chemical and
      behavioural dependency of medical students is not higher than the other
      population.
CI  - Copyright (c) 2011 L'Encephale, Paris. Published by Elsevier Masson SAS. All
      rights reserved.
FAU - Moaouad, J
AU  - Moaouad J
AD  - Hotel-Dieu de France, Achrafieh, Liban.
FAU - Kazour, F
AU  - Kazour F
FAU - Haddad, R
AU  - Haddad R
FAU - Rouhayem, J
AU  - Rouhayem J
FAU - Chammai, R
AU  - Chammai R
FAU - Richa, S
AU  - Richa S
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - La dependance chimique et comportementale chez les etudiants en medecine. Etude
      comparative chez une population d'etudiants libanais.
DEP - 20120124
PL  - France
TA  - Encephale
JT  - L'Encephale
JID - 7505643
SB  - IM
MH  - Adolescent
MH  - Alcoholism/*epidemiology/*ethnology/psychology
MH  - Behavior, Addictive/*epidemiology/*ethnology/psychology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Gambling
MH  - Humans
MH  - Internet
MH  - Lebanon
MH  - Male
MH  - Schools, Medical/statistics & numerical data
MH  - Sex Factors
MH  - Stress, Psychological/complications
MH  - Students, Medical/*psychology/*statistics & numerical data
MH  - Substance-Related Disorders/*epidemiology/*ethnology/psychology
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2012/12/04 06:00
MHDA- 2013/06/05 06:00
CRDT- 2012/12/04 06:00
PHST- 2010/04/28 00:00 [received]
PHST- 2011/09/28 00:00 [accepted]
PHST- 2012/12/04 06:00 [entrez]
PHST- 2012/12/04 06:00 [pubmed]
PHST- 2013/06/05 06:00 [medline]
AID - S0013-7006(11)00235-1 [pii]
AID - 10.1016/j.encep.2011.12.010 [doi]
PST - ppublish
SO  - Encephale. 2012 Dec;38(6):467-72. doi: 10.1016/j.encep.2011.12.010. Epub 2012 Jan
      24.


PMID- 23200601
OWN - NLM
STAT- MEDLINE
DCOM- 20140928
LR  - 20220309
IS  - 1873-1465 (Electronic)
IS  - 0031-9406 (Linking)
VI  - 99
IP  - 4
DP  - 2013 Dec
TI  - Exercise and self-management for people with chronic knee, hip or lower back
      pain: a cluster randomised controlled trial of clinical and cost-effectiveness.
      Study protocol.
PG  - 352-7
LID - 10.1016/j.physio.2012.09.002 [doi]
LID - S0031-9406(12)00087-9 [pii]
AB  - OBJECTIVES: Chronic musculoskeletal pain and osteoarthritis can significantly
      limit the functional independence of individuals, and given that 25% of the
      population experience these problems, the socioeconomic impact is immense.
      Exercise and self-management have proven benefits for these conditions, but most 
      trials tailor interventions for specific joints. Epidemiological data
      demonstrates that many older people with degenerative joint problems experience
      pain and functional difficulty in other joints, seeking further healthcare input 
      when these present. Managing multiple joint presentations simultaneously could
      potentially reduce the need for repeat visits to healthcare professionals as
      advice is frequently the same for differing site presentations. This single-blind
      cluster randomised controlled trial will determine the clinical and
      cost-effectiveness of an exercise and self-management intervention delivered to
      people over-50 with either hip, knee or lower back pain, compared to 'standard'
      GP care. A qualitative analysis will also establish the acceptability of the
      intervention. METHODS: 352 people with chronic degenerative musculoskeletal pain 
      of the hip, knee or lower back will be recruited from primary care. GP surgeries 
      will be randomised to either the intervention or control arms. Participants in
      the intervention arm will receive a 6-week group exercise and self-management
      programme facilitated by a physiotherapist in primary care. Participants
      allocated to the control arm will continue under 'standard' GP care. The primary 
      outcome measure is the Dysfunction Index of the Short Musculoskeletal Functional 
      Assessment (SMFA). ANALYSIS: Individual patient responses will be modelled using 
      a mixed effects linear regression, allowing for the clustering effects. Resource 
      use and related intervention costs will be estimated and broader resource use
      data will be collected using a version of the Client Service Receipt Inventory
      adapted for musculoskeletal relevance. In addition, a cost-utility analysis will 
      be undertaken to present an estimate of the incremental cost per QALY. A
      qualitative analysis investigating the acceptability of the intervention to
      participants and healthcare professionals will also be undertaken and
      thematically analysed. ETHICS AND DISSEMINATION: Ethical approval was received
      from South West 4 REC, identification number 11/SW/0053. Study findings will be
      disseminated via conference and journal presentation; via arthritis charitable
      organisations; and through local GP consortia.
CI  - Copyright (c) 2012 Chartered Society of Physiotherapy. Published by Elsevier Ltd.
      All rights reserved.
FAU - Walsh, Nicola
AU  - Walsh N
AD  - Faculty of Health & Life Sciences, University of the West of England, Bristol,
      United Kingdom. Electronic address: nicola.walsh@uwe.ac.uk.
FAU - Cramp, Fiona
AU  - Cramp F
FAU - Palmer, Shea
AU  - Palmer S
FAU - Pollock, Jon
AU  - Pollock J
FAU - Hampson, Lisa
AU  - Hampson L
FAU - Gooberman-Hill, Rachael
AU  - Gooberman-Hill R
FAU - Green, Colin
AU  - Green C
FAU - Jones, Louise
AU  - Jones L
FAU - Phillips, Sonia
AU  - Phillips S
FAU - Johnson, Liz
AU  - Johnson L
FAU - Hurley, Mike
AU  - Hurley M
LA  - eng
GR  - G0800792/MRC_/Medical Research Council/United Kingdom
GR  - ARC_/Arthritis Research UK/United Kingdom
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20121130
PL  - England
TA  - Physiotherapy
JT  - Physiotherapy
JID - 0401223
SB  - IM
MH  - Chronic Pain/rehabilitation/*therapy
MH  - *Clinical Protocols
MH  - Cost-Benefit Analysis
MH  - *Exercise Therapy
MH  - Hip Joint
MH  - Humans
MH  - Knee Joint
MH  - Low Back Pain/rehabilitation/*therapy
MH  - Musculoskeletal Pain/rehabilitation/*therapy
MH  - *Self Care
MH  - Single-Blind Method
OTO - NOTNLM
OT  - Arthralgia
OT  - Exercise
OT  - Osteoarthritis
OT  - Self-care
EDAT- 2012/12/04 06:00
MHDA- 2014/10/01 06:00
CRDT- 2012/12/04 06:00
PHST- 2012/02/15 00:00 [received]
PHST- 2012/09/16 00:00 [accepted]
PHST- 2012/12/04 06:00 [entrez]
PHST- 2012/12/04 06:00 [pubmed]
PHST- 2014/10/01 06:00 [medline]
AID - S0031-9406(12)00087-9 [pii]
AID - 10.1016/j.physio.2012.09.002 [doi]
PST - ppublish
SO  - Physiotherapy. 2013 Dec;99(4):352-7. doi: 10.1016/j.physio.2012.09.002. Epub 2012
      Nov 30.


PMID- 23200071
OWN - NLM
STAT- MEDLINE
DCOM- 20130614
LR  - 20220317
IS  - 1532-9488 (Electronic)
IS  - 1043-0679 (Linking)
VI  - 24
IP  - 3
DP  - 2012 Autumn
TI  - What are the effects of sleep deprivation and fatigue in surgical practice?
PG  - 166-75
LID - 10.1053/j.semtcvs.2012.06.005 [doi]
LID - S1043-0679(12)00088-3 [pii]
AB  - Sleep deprivation and fatigue have long been linked with accidents in high-risk
      industries and serious errors in the medical profession, but their effects on
      surgical performance are less well understood. This article outlines the
      important functions that human sleep serves and describes the neurobehavioral
      effects of wakefulness extension and mental fatigue that are relevant to surgical
      performance, including attentional failure, risk taking, and decision-making
      bias. Methods used to explore the effects of sleep deprivation and fatigue on
      surgical performance, from laboratory studies to outcomes data, are discussed;
      the findings are summarized; and important deficiencies in the literature are
      highlighted. Future strategies to mitigate performance decline, such as novel
      assessment tools and countermeasures with proven efficacy, are presented, and
      their deployment is discussed in the context of key ethical principles.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Sugden, Colin
AU  - Sugden C
AD  - Division of Surgery, Department of Surgery and Cancer, Imperial College London,
      St Mary's Hospital, London, United Kingdom. c.sugden@imperial.ac.uk
FAU - Athanasiou, Thanos
AU  - Athanasiou T
FAU - Darzi, Ara
AU  - Darzi A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Semin Thorac Cardiovasc Surg
JT  - Seminars in thoracic and cardiovascular surgery
JID - 8917640
SB  - IM
MH  - Attention
MH  - Choice Behavior
MH  - *Clinical Competence
MH  - Cognition
MH  - Education, Medical, Graduate
MH  - Humans
MH  - Internship and Residency
MH  - Mental Fatigue/*etiology/prevention & control/psychology
MH  - Motor Skills
MH  - Patient Safety
MH  - *Personnel Staffing and Scheduling/ethics
MH  - Risk Assessment
MH  - Risk Factors
MH  - Risk-Taking
MH  - Sleep Deprivation/*etiology/prevention & control/psychology
MH  - Surgical Procedures, Operative/*education/ethics
MH  - Time Factors
MH  - *Workload
EDAT- 2012/12/04 06:00
MHDA- 2013/06/15 06:00
CRDT- 2012/12/04 06:00
PHST- 2012/06/25 00:00 [accepted]
PHST- 2012/12/04 06:00 [entrez]
PHST- 2012/12/04 06:00 [pubmed]
PHST- 2013/06/15 06:00 [medline]
AID - S1043-0679(12)00088-3 [pii]
AID - 10.1053/j.semtcvs.2012.06.005 [doi]
PST - ppublish
SO  - Semin Thorac Cardiovasc Surg. 2012 Autumn;24(3):166-75. doi:
      10.1053/j.semtcvs.2012.06.005.


PMID- 23199824
OWN - NLM
STAT- MEDLINE
DCOM- 20140421
LR  - 20161021
IS  - 1578-1291 (Electronic)
IS  - 1130-2399 (Linking)
VI  - 24
IP  - 2
DP  - 2013 Apr-Jun
TI  - [Perception of the critical patient on nursing cares: an approach to the concept 
      of satisfaction].
PG  - 51-62
LID - 10.1016/j.enfi.2012.09.003 [doi]
LID - S1130-2399(12)00092-2 [pii]
AB  - INTRODUCTION: Level of satisfaction is a key indicator of quality of care. There 
      are many tools that measure satisfaction with nursing care, however they do not
      respond to the reality of the critical care patient or to our context.
      OBJECTIVES: To define and to identify the dimensions of the satisfaction of
      patients admitted to the intensive care unit of a tertiary hospital with nursing 
      cares and to define and identify the dimensions of the concept of satisfaction
      from their point of view. MATERIAL AND METHODS: A qualitative research study was 
      conducted according to the Grounded Theory Method in three Intensive Care Units
      with 34 individual boxes, with theoretical sampling. Nineteen patients remained
      after data saturation sampling. Data collection was obtained through recorded
      in-depth interviews and field logbook. Contents analysis was made according to
      the Grounded Theory. Guba and Lincoln rigor's criteria were followed. There was a
      favorable report from the Hospital's Ethics Committee and informed consent was
      obtained from the patients. RESULTS: Four categories were found: The definition
      and dimensions of the satisfaction concept, expectations and life experiences.
      The participants included the following dimensions in their satisfaction
      definition: professional competences, human, technical and continuous cares. The 
      combination of these elements produces feelings of security, calmness, being
      monitored, feeling like a person, perceiving a close relationship and
      trustfulness with the nurse who performs the individualized cares. CONCLUSIONS:
      The definition and dimensions of satisfaction concept from the patient's point of
      view show the important aspects of the person and also clarify their dimensions, 
      allowing the construction of tools more in line with the context and real
      perception.
CI  - Copyright (c) 2012 Elsevier Espana, S.L. y SEEIUC. All rights reserved.
FAU - Romero-Garcia, M
AU  - Romero-Garcia M
AD  - Unidad de Cuidados Intensivos, Hospital de Santa Creu i Sant Pau, Barcelona,
      Espana. mromero@santpau.cat.
FAU - de la Cueva-Ariza, L
AU  - de la Cueva-Ariza L
FAU - Jover-Sancho, C
AU  - Jover-Sancho C
FAU - Delgado-Hito, P
AU  - Delgado-Hito P
FAU - Acosta-Mejuto, B
AU  - Acosta-Mejuto B
FAU - Sola-Ribo, M
AU  - Sola-Ribo M
FAU - Juando-Prats, C
AU  - Juando-Prats C
FAU - Ricart-Basagana, M T
AU  - Ricart-Basagana MT
FAU - Sola-Sole, N
AU  - Sola-Sole N
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
TT  - La percepcion del paciente critico sobre los cuidados enfermeros: una
      aproximacion al concepto de satisfaccion.
DEP - 20121129
PL  - Spain
TA  - Enferm Intensiva
JT  - Enfermeria intensiva
JID - 9517771
MH  - Adult
MH  - Aged
MH  - *Attitude
MH  - *Critical Care Nursing
MH  - Female
MH  - Humans
MH  - Intensive Care Units
MH  - Male
MH  - Middle Aged
MH  - *Patient Satisfaction
MH  - Young Adult
EDAT- 2012/12/04 06:00
MHDA- 2014/04/22 06:00
CRDT- 2012/12/04 06:00
PHST- 2012/09/20 00:00 [received]
PHST- 2012/09/28 00:00 [accepted]
PHST- 2012/12/04 06:00 [entrez]
PHST- 2012/12/04 06:00 [pubmed]
PHST- 2014/04/22 06:00 [medline]
AID - S1130-2399(12)00092-2 [pii]
AID - 10.1016/j.enfi.2012.09.003 [doi]
PST - ppublish
SO  - Enferm Intensiva. 2013 Apr-Jun;24(2):51-62. doi: 10.1016/j.enfi.2012.09.003. Epub
      2012 Nov 29.


PMID- 23199336
OWN - NLM
STAT- MEDLINE
DCOM- 20131202
LR  - 20211021
IS  - 1747-5341 (Electronic)
IS  - 1747-5341 (Linking)
VI  - 7
DP  - 2012 Dec 3
TI  - The absence of cruelty is not the presence of humanness: physicians and the death
      penalty in the United States.
PG  - 13
LID - 10.1186/1747-5341-7-13 [doi]
AB  - The death penalty by lethal injection is a legal punishment in the United States.
      Sodium Thiopental, once used in the death penalty cocktail, is no longer
      available for use in the United States as a consequence of this association.
      Anesthesiologists possess knowledge of Sodium Thiopental and possible chemical
      alternatives. Further, lethal injection has the look and feel of a medical act
      thereby encouraging physician participation and comment. Concern has been raised 
      that the death penalty by lethal injection, is cruel. Physicians are ethically
      directed to prevent cruelty within the doctor-patient relationship and ethically 
      prohibited from participation in any component of the death penalty. The US
      Supreme Court ruled that the death penalty is not cruel per se and is not in
      conflict with the 8th amendment of the US constitution. If the death penalty is
      not cruel, it requires no further refinement. If, on the other hand, the death
      penalty is in fact cruel, physicians have no mandate outside of the doctor
      patient relationship to reduce cruelty. Any intervention in the name of cruelty
      reduction, in the setting of lethal injection, does not lead to a more humane
      form of punishment. If physicians contend that the death penalty can be botched, 
      they wrongly direct that it can be improved. The death penalty cocktail, as a
      method to reduce suffering during execution, is an unverifiable claim. At best,
      anesthetics produce an outward appearance of calmness only and do not address
      suffering as a consequence of the anticipation of death on the part of the
      condemned.
FAU - Zivot, Joel B
AU  - Zivot JB
AD  - Department of Anesthesiology, Emory University, 201 Dowman Drive, Atlanta, GA
      30322, USA.
LA  - eng
PT  - Journal Article
DEP - 20121203
PL  - England
TA  - Philos Ethics Humanit Med
JT  - Philosophy, ethics, and humanities in medicine : PEHM
JID - 101258058
SB  - IM
MH  - *Capital Punishment
MH  - Codes of Ethics
MH  - *Ethics, Medical
MH  - *Human Rights
MH  - Humans
MH  - Physician-Patient Relations/*ethics
MH  - Physicians/*ethics
MH  - Prisoners
MH  - United States
PMC - PMC3563523
EDAT- 2012/12/04 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/12/04 06:00
PHST- 2012/02/08 00:00 [received]
PHST- 2012/11/27 00:00 [accepted]
PHST- 2012/12/04 06:00 [entrez]
PHST- 2012/12/04 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 1747-5341-7-13 [pii]
AID - 10.1186/1747-5341-7-13 [doi]
PST - epublish
SO  - Philos Ethics Humanit Med. 2012 Dec 3;7:13. doi: 10.1186/1747-5341-7-13.


PMID- 23199259
OWN - NLM
STAT- MEDLINE
DCOM- 20130613
LR  - 20131121
IS  - 1520-5851 (Electronic)
IS  - 0013-936X (Linking)
VI  - 47
IP  - 1
DP  - 2013 Jan 2
TI  - Predicting water quality criteria for protecting aquatic life from
      physicochemical properties of metals or metalloids.
PG  - 446-53
LID - 10.1021/es303309h [doi]
AB  - Metals are widely distributed pollutants in water and can have detrimental
      effects on some aquatic life and humans. Over the past few decades, the United
      States Environmental Protection Agency (U.S. EPA) has published a series of
      criteria guidelines, which contain specific criteria maximum concentrations
      (CMCs) for 10 metals. However, CMCs for other metals are still lacking because of
      financial, practical, or ethical restrictions on toxicity testing. Herein, a
      quantitative structure activity relationship (QSAR) method was used to develop a 
      set of predictive relationships, based on physical and chemical characteristics
      of metals, and predict acute toxicities of each species for five phyla and eight 
      families of organisms for 25 metals or metalloids. In addition, species
      sensitivity distributions (SSDs) were developed as independent methods for
      determining predictive CMCs. The quantitative ion character-activity
      relationships (QICAR) analysis showed that the softness index (sigmap), maximum
      complex stability constants (log -beta(n)), electrochemical potential
      (DeltaE(0)), and covalent index (X(m)(2)r) were the minimum set of structure
      parameters required to predict toxicity of metals to eight families of
      representative organisms. Predicted CMCs for 10 metals are in reasonable
      agreement with those recommended previously by U.S. EPA within a difference of
      1.5 orders of magnitude. CMCs were significantly related to sigmap (r(2) = 0.76, 
      P = 7.02 x 10(-9)) and log -beta(n) (r(2) = 0.73, P = 3.88 x 10(-8)). The novel
      QICAR-SSD model reported here is a rapid, cost-effective, and reasonably accurate
      method, which can provide a beneficial supplement to existing methodologies for
      developing preliminarily screen level toxicities or criteria for metals, for
      which little or no relevant information on the toxicity to particular classes of 
      aquatic organisms exists.
FAU - Wu, Fengchang
AU  - Wu F
AD  - State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese
      Research Academy of Environmental Sciences, Beijing 100012, China.
      wufengchang@vip.skleg.cn
FAU - Mu, Yunsong
AU  - Mu Y
FAU - Chang, Hong
AU  - Chang H
FAU - Zhao, Xiaoli
AU  - Zhao X
FAU - Giesy, John P
AU  - Giesy JP
FAU - Wu, K Benjamin
AU  - Wu KB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121210
PL  - United States
TA  - Environ Sci Technol
JT  - Environmental science & technology
JID - 0213155
RN  - 0 (Metals)
RN  - 0 (Water Pollutants, Chemical)
RN  - N712M78A8G (Arsenic)
SB  - IM
MH  - Animals
MH  - Araceae
MH  - Arsenic/chemistry/*toxicity
MH  - Arthropods
MH  - Bufonidae
MH  - Carps
MH  - Lethal Dose 50
MH  - Metals/chemistry/*toxicity
MH  - *Models, Theoretical
MH  - Quantitative Structure-Activity Relationship
MH  - Rotifera
MH  - Water Pollutants, Chemical/chemistry/*toxicity
MH  - Water Quality
EDAT- 2012/12/04 06:00
MHDA- 2013/06/14 06:00
CRDT- 2012/12/04 06:00
PHST- 2012/12/04 06:00 [entrez]
PHST- 2012/12/04 06:00 [pubmed]
PHST- 2013/06/14 06:00 [medline]
AID - 10.1021/es303309h [doi]
PST - ppublish
SO  - Environ Sci Technol. 2013 Jan 2;47(1):446-53. doi: 10.1021/es303309h. Epub 2012
      Dec 10.


PMID- 23198961
OWN - NLM
STAT- MEDLINE
DCOM- 20130606
LR  - 20211021
IS  - 1475-2875 (Electronic)
IS  - 1475-2875 (Linking)
VI  - 11
DP  - 2012 Dec 2
TI  - Stabilizing supply of artemisinin and artemisinin-based combination therapy in an
      era of wide-spread scale-up.
PG  - 399
LID - 10.1186/1475-2875-11-399 [doi]
AB  - The global demand for artemisinin-based combination therapy (ACT) has grown
      sharply since its recommendation by the World Health Organization in 2002.
      However, a combination of financing and programmatic uncertainties, limited
      suppliers of finished products, information opacity across the different tiers in
      the supply chain, and widespread fluctuations in raw material prices have
      together contributed to a market fraught with demand and supply uncertainties and
      price volatility. Various short-term solutions have been deployed to alleviate
      supply shortages caused by these challenges; however, new mechanisms are required
      to build resilience into the supply chain. This review concludes that a mix of
      strategies is required to stabilize the artemisinin and ACT market. First, better
      and more effective pooling of demand and supply risks and better contracting to
      allow risk sharing among the stakeholders are needed. Physical and financial
      buffer stocks will enable better matching of demand and supply in the short and
      medium term. Secondly, physical buffers will allow stable supplies when there are
      procurement and supply management challenges while financial buffer funds will
      address issues around funding disruptions. Finally, in the medium to long term,
      significant investments in country level system strengthening will be required to
      minimize national level demand uncertainties. In addition a voluntary standard
      for extractors to ensure appropriate purchasing and sales practices as well as
      minimum quality and ethical standards could help stabilize the artemisinin market
      in the long term.
FAU - Shretta, Rima
AU  - Shretta R
AD  - Systems for Improved Access to Pharmaceuticals Services, Management Sciences for 
      Health, 4301 North Fairfax Drive, Suite 400, Arlington, VA 22203, USA.
      rshretta@msh.org
FAU - Yadav, Prashant
AU  - Yadav P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20121202
PL  - England
TA  - Malar J
JT  - Malaria journal
JID - 101139802
RN  - 0 (Antimalarials)
RN  - 0 (Artemisinins)
RN  - 9RMU91N5K2 (artemisinin)
SB  - IM
MH  - Antimalarials/*administration & dosage/economics/*supply & distribution
MH  - Artemisinins/*administration & dosage/economics/*supply & distribution
MH  - Drug Costs
MH  - Drug Industry/economics/trends
MH  - Drug Therapy, Combination
MH  - Global Health
MH  - Humans
MH  - Malaria/drug therapy/economics
PMC - PMC3556147
EDAT- 2012/12/04 06:00
MHDA- 2013/06/07 06:00
CRDT- 2012/12/04 06:00
PHST- 2012/09/07 00:00 [received]
PHST- 2012/11/26 00:00 [accepted]
PHST- 2012/12/04 06:00 [entrez]
PHST- 2012/12/04 06:00 [pubmed]
PHST- 2013/06/07 06:00 [medline]
AID - 1475-2875-11-399 [pii]
AID - 10.1186/1475-2875-11-399 [doi]
PST - epublish
SO  - Malar J. 2012 Dec 2;11:399. doi: 10.1186/1475-2875-11-399.


PMID- 23198940
OWN - NLM
STAT- MEDLINE
DCOM- 20130920
LR  - 20211203
IS  - 1840-4812 (Electronic)
IS  - 1512-8601 (Linking)
VI  - 12
IP  - 4
DP  - 2012 Nov
TI  - Assessment of relatedness between neurocan gene as bipolar disorder
      susceptibility locus and schizophrenia.
PG  - 245-8
AB  - Large scale genetic association meta-analyses showed that neurocan (NCAN) gene
      polymorphism rs1064395 is susceptibility locus for bipolar disorder. These
      studies also included patients with bipolar disorder originated from Bosnia and
      Herzegovina. Followed by theory of shared genetic elements between bipolar
      disorder and schizophrenia susceptibility, other studies explored several genetic
      factors with schizophrenia vulnerability as well. In this work, authors
      investigated the association between previously confirmed bipolar disorder
      genetic risk factor- neurocan with schizophrenia in a population sample of Bosnia
      and Herzegovina. Ethical aspects of this research were assessed by Ethics
      Committee of Clinical Center University of Sarajevo. Blood samples for DNA
      extraction were taken from the total of 86 patients and healthy individuals who
      previously signed informed consent. Genotyping for rs 1064395 was done using
      direct sequencing method. A case-control analysis of common genetic polymorphism 
      within neurocan gene and schizophrenia status in a consecutively sampled patient 
      cohort have been done using Fisher-exact test with odds-ratio calculation. No
      statistically significant allele and genotype association with disease status was
      found (p>0.05). Our finding supports the fact that large-scale genetic
      association studies approach need to be employed when detecting the variants with
      small additive effect in phenotypes with complex ethiology.
FAU - Oruc, Lilijana
AU  - Oruc L
AD  - Psychiatric Clinic, Clinical Center University of Sarajevo, Bolnicka 25, 71000
      Sarajevo, Bosnia and Herzegovina.
FAU - Kapur-Pojskic, Lejla
AU  - Kapur-Pojskic L
FAU - Ramic, Jasmin
AU  - Ramic J
FAU - Pojskic, Naris
AU  - Pojskic N
FAU - Bajrovic, Kasim
AU  - Bajrovic K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Bosnia and Herzegovina
TA  - Bosn J Basic Med Sci
JT  - Bosnian journal of basic medical sciences
JID - 101200947
RN  - 0 (Chondroitin Sulfate Proteoglycans)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neurocan)
RN  - 148684-98-4 (NCAN protein, human)
SB  - IM
MH  - Base Sequence
MH  - Bipolar Disorder/*genetics
MH  - Chondroitin Sulfate Proteoglycans/*genetics
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Lectins, C-Type/*genetics
MH  - Molecular Sequence Data
MH  - Nerve Tissue Proteins/*genetics
MH  - Neurocan
MH  - Schizophrenia/*genetics
PMC - PMC4362500
EDAT- 2012/12/04 06:00
MHDA- 2013/09/21 06:00
CRDT- 2012/12/04 06:00
PHST- 2012/12/04 06:00 [entrez]
PHST- 2012/12/04 06:00 [pubmed]
PHST- 2013/09/21 06:00 [medline]
AID - 10.17305/bjbms.2012.2446 [doi]
PST - ppublish
SO  - Bosn J Basic Med Sci. 2012 Nov;12(4):245-8. doi: 10.17305/bjbms.2012.2446.


PMID- 23198700
OWN - NLM
STAT- MEDLINE
DCOM- 20150209
LR  - 20220318
IS  - 1365-2214 (Electronic)
IS  - 0305-1862 (Linking)
VI  - 39
IP  - 6
DP  - 2013 Nov
TI  - Respect for autonomy in the healthcare context: observations from a qualitative
      study of young adults with cerebral palsy.
PG  - 873-9
LID - 10.1111/cch.12018 [doi]
AB  - BACKGROUND: Respect for patient autonomy is a cornerstone of contemporary medical
      ethics and clinical practice. In its different shapes and forms (e.g. being
      informed, being engaged in discussions and decisions about medical care and being
      supported in developing healthcare preferences and choices), patient autonomy has
      been fostered by both paediatric and adult professional societies. The transition
      from paediatric to adult care creates a complex situation where autonomy for
      medical decisions shifts to the developing adolescent. More specific challenges
      to respect for autonomy may be experienced by young adults with cerebral palsy in
      the transition period where, for example, language and motor impairments may
      affect communication skills and this may be conflated with cognitive disability. 
      AIM: To characterize perspectives towards autonomy in the healthcare context for 
      young adults with cerebral palsy. METHOD: We carried out semi-structured
      interviews with 14 young adults (aged 18-25) with cerebral palsy. The audiotaped 
      interviews were transcribed verbatim and analysed using a conventional thematic
      qualitative content analysis. RESULTS: Participants displayed a range of
      attitudes towards autonomy, suggesting that the value of autonomy is considered
      in light of competing values and of context. Testimonials from participants
      demonstrated that both contextual (e.g. ill-adapted health care, lack of
      specialized public transport) and relational (e.g. attitudes towards parental
      involvement in decision making) factors negatively or positively impact autonomy.
      CONCLUSION: We observed that there were four key elements interwoven in
      participants' characterization of autonomy: the coupling of decisional and
      physical autonomy, the influences of family and society on autonomy, the
      influence of healthcare professionals on autonomy and the need for preparation
      for autonomy.
CI  - (c) 2012 John Wiley & Sons Ltd.
FAU - Racine, E
AU  - Racine E
AD  - Neuroethics Research Unit, Institut de recherches cliniques de Montreal (IRCM),
      Montreal, QC, Canada; Department of Medicine and Department of Social and
      Preventive Medicine, Universite de Montreal, Montreal, QC, Canada; Departments of
      Neurology and Neurosurgery, Medicine & Biomedical Ethics Unit, McGill University,
      Montreal, QC, Canada.
FAU - Lariviere-Bastien, D
AU  - Lariviere-Bastien D
FAU - Bell, E
AU  - Bell E
FAU - Majnemer, A
AU  - Majnemer A
FAU - Shevell, M
AU  - Shevell M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121130
PL  - England
TA  - Child Care Health Dev
JT  - Child: care, health and development
JID - 7602632
SB  - IM
MH  - Adaptation, Psychological
MH  - Adolescent
MH  - Adult
MH  - Attitude of Health Personnel
MH  - Cerebral Palsy/*psychology
MH  - Choice Behavior
MH  - Decision Making
MH  - Ethics, Medical
MH  - Evaluation Studies as Topic
MH  - Female
MH  - Humans
MH  - Male
MH  - Parent-Child Relations
MH  - *Personal Autonomy
MH  - *Transition to Adult Care
MH  - Young Adult
OTO - NOTNLM
OT  - autonomy
OT  - cerebral palsy
OT  - ethics
OT  - health services
OT  - independence
EDAT- 2012/12/04 06:00
MHDA- 2015/02/11 06:00
CRDT- 2012/12/04 06:00
PHST- 2012/09/16 00:00 [accepted]
PHST- 2012/12/04 06:00 [entrez]
PHST- 2012/12/04 06:00 [pubmed]
PHST- 2015/02/11 06:00 [medline]
AID - 10.1111/cch.12018 [doi]
PST - ppublish
SO  - Child Care Health Dev. 2013 Nov;39(6):873-9. doi: 10.1111/cch.12018. Epub 2012
      Nov 30.


PMID- 23198618
OWN - NLM
STAT- MEDLINE
DCOM- 20121218
LR  - 20181202
IS  - 0025-7028 (Print)
IS  - 0025-7028 (Linking)
VI  - 101
IP  - 3
DP  - 2012
TI  - Article on medical ethics.
PG  - 5; discussion 5
FAU - De Guzman, Grace
AU  - De Guzman G
LA  - eng
PT  - Letter
PT  - Comment
PL  - United States
TA  - J Med Assoc Ga
JT  - Journal of the Medical Association of Georgia
JID - 7505620
SB  - IM
CON - J Med Assoc Ga. 2012;101(2):22-3. PMID: 22872972
MH  - *Attitude of Health Personnel
MH  - *Ethics, Medical
MH  - Female
MH  - Humans
MH  - Male
MH  - *Religion and Medicine
MH  - Students, Medical/*psychology
EDAT- 2012/12/04 06:00
MHDA- 2012/12/19 06:00
CRDT- 2012/12/04 06:00
PHST- 2012/12/04 06:00 [entrez]
PHST- 2012/12/04 06:00 [pubmed]
PHST- 2012/12/19 06:00 [medline]
PST - ppublish
SO  - J Med Assoc Ga. 2012;101(3):5; discussion 5.


PMID- 23198363
OWN - NLM
STAT- MEDLINE
DCOM- 20121218
LR  - 20121203
IS  - 1029-4864 (Print)
IS  - 1029-4864 (Linking)
VI  - 67
IP  - 3
DP  - 2012 Apr
TI  - Dental ethics case 20. Suspected malignancy: to tell or not to tell the truth?
PG  - 134-5
FAU - Naidoo, S
AU  - Naidoo S
AD  - Faculty of Dentistry, University of the Western Cape, Department of Community
      Dentistry, Private Bag X1, Tygerberg 7505. suenaidoo@uwc.ac.za
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - South Africa
TA  - SADJ
JT  - SADJ : journal of the South African Dental Association = tydskrif van die
      Suid-Afrikaanse Tandheelkundige Vereniging
JID - 9812497
MH  - *Ethics, Dental
MH  - Humans
MH  - Mandibular Neoplasms/*diagnosis
MH  - Symptom Assessment/*ethics
MH  - Truth Disclosure/*ethics
EDAT- 2012/12/04 06:00
MHDA- 2012/12/19 06:00
CRDT- 2012/12/04 06:00
PHST- 2012/12/04 06:00 [entrez]
PHST- 2012/12/04 06:00 [pubmed]
PHST- 2012/12/19 06:00 [medline]
PST - ppublish
SO  - SADJ. 2012 Apr;67(3):134-5.


PMID- 23198355
OWN - NLM
STAT- MEDLINE
DCOM- 20121218
LR  - 20121203
IS  - 1029-4864 (Print)
IS  - 1029-4864 (Linking)
VI  - 67
IP  - 4
DP  - 2012 May
TI  - Dental ethics case 21. Extreme makeovers--the ethics of aesthetic dentistry.
PG  - 184-5
FAU - Naidoo, S
AU  - Naidoo S
AD  - Faculty of Dentistry, University of the Western Cape, Department of Community
      Dentistry, Private Bag X1, Tygerberg. suenaidoo@uwc.ac.za
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - South Africa
TA  - SADJ
JT  - SADJ : journal of the South African Dental Association = tydskrif van die
      Suid-Afrikaanse Tandheelkundige Vereniging
JID - 9812497
MH  - Adolescent
MH  - *Esthetics, Dental
MH  - *Ethics, Dental
MH  - Female
MH  - Humans
MH  - Informed Consent
MH  - Patient Preference
MH  - Refusal to Treat/*ethics
MH  - Truth Disclosure
MH  - Unnecessary Procedures/*ethics
EDAT- 2012/12/04 06:00
MHDA- 2012/12/19 06:00
CRDT- 2012/12/04 06:00
PHST- 2012/12/04 06:00 [entrez]
PHST- 2012/12/04 06:00 [pubmed]
PHST- 2012/12/19 06:00 [medline]
PST - ppublish
SO  - SADJ. 2012 May;67(4):184-5.


PMID- 23198351
OWN - NLM
STAT- MEDLINE
DCOM- 20121218
LR  - 20181202
IS  - 1029-4864 (Print)
IS  - 1029-4864 (Linking)
VI  - 67
IP  - 4
DP  - 2012 May
TI  - Orofacial injuries among traditional bare-fisted fighters.
PG  - 164-7
AB  - UNLABELLED: The continuing practice and increased popularity of bare-knuckled
      fighting in South Africa poses a challenge for healthcare workers dedicated to
      preventive dentistry and to preventing the spread of HIV and other communicable
      diseases. OBJECTIVES: To determine the prevalence and types of orofacial injuries
      inflicted during bare-fisted fighting tournaments in Limpopo Province. METHOD:
      The study was approved by the Ethics Committee of the University of Limpopo,
      Polokwane Campus and the Bare Fist Tournament committee in Tshaulu respectively. 
      A cross-sectional study was conducted amongst 201 fist fighters participating in 
      boxing tournaments at Tshaulu village in Limpopo Province, between December 2009 
      and January 2011. Demographic data, including socioeconomic and behavioral
      characteristics, were collected using a questionnaire administered before the
      fight. After each bout, injured fighters were referred to a mobile dental clinic 
      for clinical examination by dentists. The type and site of injuries were
      recorded. RESULTS: Of 201 fighters, the majority (53%) were unemployed, 49% were 
      married and 23% were fighting for the first time. One-hundred-and-sixty-five
      received orofacial injuries. Eight of the fighters were resuscitated in the
      mobile dental clinic. Sixty-seven percent had at least one traumatic injury to
      the face: facial laceration (53%); bone fractures (5%), dental injuries (31%) and
      mandibular dislocation (11%). Tooth fractures (59.7%) were the most common dental
      injuries. CONCLUSION: Orofacial injuries are frequent among traditional fist
      fighters. Teeth and soft tissue sustained the most injuries. It is recommended
      that protective devices such as mouth guards and headgears be introduced among
      these fighters to reduce the incidence of orofacial injuries.
FAU - Nemutandani, M S
AU  - Nemutandani MS
AD  - Dept of Community Dentistry, Polokwane Campus, University of Limpopo.
      Ve2si@yahoo.com
FAU - Adedoja, D
AU  - Adedoja D
FAU - Nemutandani, V
AU  - Nemutandani V
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - SADJ
JT  - SADJ : journal of the South African Dental Association = tydskrif van die
      Suid-Afrikaanse Tandheelkundige Vereniging
JID - 9812497
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Boxing/*injuries
MH  - Child
MH  - Cross-Sectional Studies
MH  - Humans
MH  - Male
MH  - Maxillofacial Injuries/*epidemiology
MH  - Middle Aged
MH  - Mouth Protectors/statistics & numerical data
MH  - Prevalence
MH  - South Africa/epidemiology
MH  - Young Adult
EDAT- 2012/12/04 06:00
MHDA- 2012/12/19 06:00
CRDT- 2012/12/04 06:00
PHST- 2012/12/04 06:00 [entrez]
PHST- 2012/12/04 06:00 [pubmed]
PHST- 2012/12/19 06:00 [medline]
PST - ppublish
SO  - SADJ. 2012 May;67(4):164-7.


PMID- 23197820
OWN - NLM
STAT- MEDLINE
DCOM- 20130110
LR  - 20211021
IS  - 2157-6564 (Print)
IS  - 2157-6564 (Linking)
VI  - 1
IP  - 5
DP  - 2012 May
TI  - Specimen collection for induced pluripotent stem cell research: harmonizing the
      approach to informed consent.
PG  - 409-21
LID - 10.5966/sctm.2012-0029 [doi]
AB  - Induced pluripotent stem cells (iPSCs) have elicited excitement in both the
      scientific and ethics communities for their potential to advance basic and
      translational research. They have been hailed as an alternative to derivation
      from embryos that provides a virtually unlimited source of pluripotent stem cells
      for research and therapeutic applications. However, research with iPSCs is
      ethically complex, uniquely encompassing the concerns associated with genomics,
      immortalized cell lines, transplantation, human reproduction, and biobanking.
      Prospective donation of tissue specimens for iPSC research thus requires an
      approach to informed consent that is constructed for this context. Even in the
      nascent stages of this field, approaches to informed consent have been variable
      in ways that threaten the simultaneous goals of protecting donors and
      safeguarding future research and translation, and investigators are seeking
      guidance. We address this need by providing concrete recommendations for informed
      consent that balance the perspectives of a variety of stakeholders. Our work
      combines analysis of consent form language collected from investigators worldwide
      with a conceptual balancing of normative ethical concerns, policy precedents, and
      scientific realities. Our framework asks people to consent prospectively to a
      broad umbrella of foreseeable research, including future therapeutic
      applications, with recontact possible in limited circumstances. We argue that the
      long-term goals of regenerative medicine, interest in sharing iPSC lines, and
      uncertain landscape of future research all would be served by a framework of
      ongoing communication with donors. Our approach balances the goals of iPSC and
      regenerative medicine researchers with the interests of individual research
      participants.
FAU - Lowenthal, Justin
AU  - Lowenthal J
AD  - Department of Bioethics, Clinical Center.
FAU - Lipnick, Scott
AU  - Lipnick S
FAU - Rao, Mahendra
AU  - Rao M
FAU - Hull, Sara Chandros
AU  - Hull SC
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
DEP - 20120508
PL  - England
TA  - Stem Cells Transl Med
JT  - Stem cells translational medicine
JID - 101578022
SB  - IM
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*cytology
MH  - *Informed Consent
MH  - Practice Guidelines as Topic
MH  - Regenerative Medicine/*ethics/legislation & jurisprudence
MH  - Specimen Handling/*standards
MH  - Stem Cell Research/*ethics/legislation & jurisprudence
PMC - PMC3659701
EDAT- 2012/12/01 06:00
MHDA- 2013/01/11 06:00
CRDT- 2012/12/01 06:00
PHST- 2012/12/01 06:00 [entrez]
PHST- 2012/12/01 06:00 [pubmed]
PHST- 2013/01/11 06:00 [medline]
AID - sctm.2012-0029 [pii]
AID - 10.5966/sctm.2012-0029 [doi]
PST - ppublish
SO  - Stem Cells Transl Med. 2012 May;1(5):409-21. doi: 10.5966/sctm.2012-0029. Epub
      2012 May 8.


PMID- 23197762
OWN - NLM
STAT- MEDLINE
DCOM- 20140227
LR  - 20211021
IS  - 2157-6564 (Print)
IS  - 2157-6564 (Linking)
VI  - 1
IP  - 2
DP  - 2012 Feb
TI  - Concise review: pancreas regeneration: recent advances and perspectives.
PG  - 150-9
LID - 10.5966/sctm.2011-0025 [doi]
AB  - The replacement of functional pancreatic beta-cells is seen as an attractive
      potential therapy for diabetes, because diabetes results from an inadequate
      beta-cell mass. Inducing replication of the remaining beta-cells and new islet
      formation from progenitors within the pancreas (neogenesis) are the most direct
      ways to increase the beta-cell mass. Stimulation of both replication and
      neogenesis have been reported in rodents, but their clinical significance must
      still be shown. Because human islet transplantation is limited by the scarcity of
      donors and graft failure within a few years, efforts have recently concentrated
      on the use of stem cells to replace the deficient beta-cells. Currently,
      embryonic stem cells and induced pluripotent stem cells achieve high levels of
      beta-cell differentiation, but their clinical use is still hampered by ethical
      issues and/or the risk of developing tumors after transplantation. Pancreatic
      epithelial cells (duct, acinar, or alpha-cells) represent an appealing
      alternative to stem cells because they demonstrate beta-cell differentiation
      capacities. Yet translation of such capacity to human cells after significant in 
      vitro expansion has yet to be achieved. Besides providing new beta-cells, cell
      therapy also has to address the question on how to protect the transplanted cells
      from destruction by the immune system via either allo- or autoimmunity.
      Encouraging developments have been made in encapsulation and immunomodulation
      techniques, but many challenges still remain. Herein, we discuss recent advances 
      in the search for beta-cell replacement therapies, current strategies for
      circumventing the immune system, and mandatory steps for new techniques to be
      translated from bench to clinics.
FAU - Lysy, Philippe A
AU  - Lysy PA
AD  - Joslin Diabetes Center, Harvard Stem Cell Institute, Harvard Medical School,
      Boston, Massachusetts, USA.
FAU - Weir, Gordon C
AU  - Weir GC
FAU - Bonner-Weir, Susan
AU  - Bonner-Weir S
LA  - eng
GR  - P30 DK036836/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20120126
PL  - England
TA  - Stem Cells Transl Med
JT  - Stem cells translational medicine
JID - 101578022
SB  - IM
MH  - Acinar Cells/cytology/physiology/transplantation
MH  - Animals
MH  - Cell Culture Techniques/methods
MH  - *Cell Differentiation
MH  - Cell Proliferation
MH  - Cell Transplantation/methods
MH  - Cell- and Tissue-Based Therapy/methods
MH  - Diabetes Mellitus/therapy
MH  - Embryonic Stem Cells/physiology/transplantation
MH  - Epithelial Cells/cytology/physiology/transplantation
MH  - Humans
MH  - Immunomodulation
MH  - Induced Pluripotent Stem Cells/cytology/physiology/transplantation
MH  - Insulin-Secreting Cells/*cytology/physiology/transplantation
MH  - Pancreas/*cytology/physiology
MH  - *Regeneration
PMC - PMC3659687
EDAT- 2012/12/01 06:00
MHDA- 2014/02/28 06:00
CRDT- 2012/12/01 06:00
PHST- 2012/12/01 06:00 [entrez]
PHST- 2012/12/01 06:00 [pubmed]
PHST- 2014/02/28 06:00 [medline]
AID - sctm.2011-0025 [pii]
AID - 10.5966/sctm.2011-0025 [doi]
PST - ppublish
SO  - Stem Cells Transl Med. 2012 Feb;1(2):150-9. doi: 10.5966/sctm.2011-0025. Epub
      2012 Jan 26.


PMID- 23197414
OWN - NLM
STAT- MEDLINE
DCOM- 20130730
LR  - 20211021
IS  - 1740-7753 (Electronic)
IS  - 1740-7745 (Linking)
VI  - 10
IP  - 1
DP  - 2013 Feb
TI  - Usefulness of prestudy assessment of patient willingness to undergo tissue biopsy
      for correlative studies in a melanoma vaccine trial.
PG  - 143-50
LID - 10.1177/1740774512464438 [doi]
AB  - BACKGROUND: Performing biopsies for correlative studies in cancer trials raises
      ethical and regulatory concerns and may impact trial accrual negatively. However,
      strategies to address these concerns remain largely unexplored. PURPOSE: We
      sought to assess the perceived risk of mandatory tissue biopsies to be performed 
      for research purposes as part of a clinical trial of a melanoma vaccine by
      administering a pretrial accrual assessment questionnaire in the population of
      interest. Furthermore, we explored how such survey data may be used to address
      potential concerns of regulatory and funding organizations that may not be able
      to assess the risks of those biopsies. Method A total of 91 melanoma patients,
      similar to potential participants in a melanoma vaccine pilot study, scored their
      willingness, on a 9-point Likert scale, to participate in vaccine trials
      involving no skin biopsy versus a skin biopsy resulting in a 3-, 6-, or 12-cm
      scar. The vaccine trial was performed with skin biopsies leaving a 6-cm scar.
      Accrual rate was assessed and that accrual was compared to the accrual of two
      similar vaccine trials without biopsy requirements. RESULTS: A total of 95% of
      the participants expressed willingness to enter a vaccine trial (likely to highly
      likely). This proportion decreased to 74%, 63%, and 59%, respectively, for
      vaccine trials requiring skin biopsy leaving a 3-, 6-, or 12-cm scar. The trial
      was designed with an estimated 40% decrease in accrual rate compared to prior
      studies (2 participants expected/month). The resulting trial with a 6-cm biopsy
      exceeded that accrual rate estimate and had a similar accrual rate to vaccine
      trials without a biopsy (4.1 vs 2.7-4.6 participants/month). LIMITATIONS:
      Potential limitations of this study include the exclusion of some questionnaire
      responses and the post hoc nature of the analysis. CONCLUSION: Willingness to
      participate in vaccine trials was decreased by the requirement for skin biopsy,
      but the size of the biopsy was less of a deterrent than expected. Findings from
      brief surveys may aid in risk assessment during regulatory review, predict
      acceptability of tissue collection for correlative studies, and support
      regulatory approval and meeting accrual goals of the study.
FAU - Judge, Joshua M
AU  - Judge JM
AD  - Department of Surgery, University of Virginia, Charlottesville, VA 22908, USA.
FAU - Chianese-Bullock, Kimberly A
AU  - Chianese-Bullock KA
FAU - Schroen, Anneke T
AU  - Schroen AT
FAU - Slingluff, Craig L Jr
AU  - Slingluff CL Jr
LA  - eng
SI  - ClinicalTrials.gov/NCT00705640
GR  - P30 CA044579/CA/NCI NIH HHS/United States
GR  - T32 CA163177/CA/NCI NIH HHS/United States
GR  - R01CA57653/CA/NCI NIH HHS/United States
GR  - R01 CA057653/CA/NCI NIH HHS/United States
GR  - P30 CA44579/CA/NCI NIH HHS/United States
GR  - M01 RR00847/RR/NCRR NIH HHS/United States
GR  - M01 RR000847/RR/NCRR NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20121129
PL  - England
TA  - Clin Trials
JT  - Clinical trials (London, England)
JID - 101197451
RN  - 0 (Cancer Vaccines)
SB  - IM
MH  - Biopsy
MH  - Cancer Vaccines/*therapeutic use
MH  - Humans
MH  - *Informed Consent
MH  - Melanoma/*pathology/*therapy
MH  - Patient Acceptance of Health Care/*statistics & numerical data
MH  - *Patient Participation
MH  - Pilot Projects
MH  - Research Design
MH  - Risk Assessment
MH  - Statistics as Topic
MH  - Surveys and Questionnaires
MH  - Virginia
PMC - PMC4167396
MID - NIHMS611466
EDAT- 2012/12/01 06:00
MHDA- 2013/07/31 06:00
CRDT- 2012/12/01 06:00
PHST- 2012/12/01 06:00 [entrez]
PHST- 2012/12/01 06:00 [pubmed]
PHST- 2013/07/31 06:00 [medline]
AID - 1740774512464438 [pii]
AID - 10.1177/1740774512464438 [doi]
PST - ppublish
SO  - Clin Trials. 2013 Feb;10(1):143-50. doi: 10.1177/1740774512464438. Epub 2012 Nov 
      29.


PMID- 23197312
OWN - NLM
STAT- MEDLINE
DCOM- 20140122
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 3
DP  - 2013 Sep
TI  - Distributed morality in an information society.
PG  - 727-43
LID - 10.1007/s11948-012-9413-4 [doi]
AB  - The phenomenon of distributed knowledge is well-known in epistemic logic. In this
      paper, a similar phenomenon in ethics, somewhat neglected so far, is
      investigated, namely distributed morality. The article explains the nature of
      distributed morality, as a feature of moral agency, and explores the implications
      of its occurrence in advanced information societies. In the course of the
      analysis, the concept of infraethics is introduced, in order to refer to the
      ensemble of moral enablers, which, although morally neutral per se, can
      significantly facilitate or hinder both positive and negative moral behaviours.
FAU - Floridi, Luciano
AU  - Floridi L
AD  - School of Humanities, University of Hertfordshire, Hertfordshire, UK.
      l.floridi@herts.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20121130
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Group Processes
MH  - Humans
MH  - Moral Obligations
MH  - *Morals
EDAT- 2012/12/01 06:00
MHDA- 2014/01/23 06:00
CRDT- 2012/12/01 06:00
PHST- 2012/08/25 00:00 [received]
PHST- 2012/11/04 00:00 [accepted]
PHST- 2012/12/01 06:00 [entrez]
PHST- 2012/12/01 06:00 [pubmed]
PHST- 2014/01/23 06:00 [medline]
AID - 10.1007/s11948-012-9413-4 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Sep;19(3):727-43. doi: 10.1007/s11948-012-9413-4. Epub 2012 
      Nov 30.


PMID- 23197145
OWN - NLM
STAT- MEDLINE
DCOM- 20130620
LR  - 20220318
IS  - 0015-5659 (Print)
IS  - 0015-5659 (Linking)
VI  - 71
IP  - 4
DP  - 2012 Nov
TI  - The radial artery and its variations: anatomical study and clinical implications.
PG  - 252-62
AB  - BACKGROUND: To describe the radial artery and its variants in origin, branching
      pattern, mode of termination, and measurements of its length and external
      diameter. MATERIAL AND METHODS: One hundred upper limbs of 30 men and 20 women
      adult cadavers were used in this study. The cadavers were obtained from the
      Anatomy Department, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi
      Arabia. The axillary region, arm, forearm, and hand of each limb were dissected
      to clarify the course and branches of the radial artery. This anatomical
      descriptive study was conducted between September 2010 and August 2012 after
      approval of the Ethical Committee. RESULTS: The mean distance of the normal
      origin of the radial artery as one of two terminal branches of the brachial
      artery was 38.7 +/- 9.5 mm in men and 36.5 +/- 8.5 mm in the upper limbs of women
      below the intercondylar line, and variant origin of the radial artery was found
      in eight limbs. The mean of radial artery length was 226.2 +/- 21.7 mm in men and
      209.9 +/- 13.9 mm in women and that of its external diameter was 3.3 +/- 0.7 mm
      in men and 3.2 +/- 0.66 mm in women at 1 cm distal to its origin; 3.1 +/- 0.73 mm
      in men and 3.0 +/- 0.66 in women at 2 cm proximal to the styloid process of the
      radius. The radial artery showed different branching patterns and three modes of 
      termination. CONCLUSIONS: Knowledge of radial artery description and its variants
      has great importance in different clinical fields and basic medical studies.
FAU - Nasr, A Y
AU  - Nasr AY
AD  - Anatomy Department, Zagazig University, Zagazig, Egypt. ashrafnaeem2012@yahoo.com
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Poland
TA  - Folia Morphol (Warsz)
JT  - Folia morphologica
JID - 0374620
SB  - IM
MH  - Adult
MH  - Arm/*anatomy & histology/*blood supply
MH  - Cadaver
MH  - Dissection
MH  - Female
MH  - Humans
MH  - Male
MH  - Muscle, Skeletal/anatomy & histology/blood supply
MH  - Radial Artery/abnormalities/*anatomy & histology
MH  - Radius/*anatomy & histology/*blood supply
MH  - *Sex Characteristics
EDAT- 2012/12/01 06:00
MHDA- 2013/06/21 06:00
CRDT- 2012/12/01 06:00
PHST- 2012/12/01 06:00 [entrez]
PHST- 2012/12/01 06:00 [pubmed]
PHST- 2013/06/21 06:00 [medline]
PST - ppublish
SO  - Folia Morphol (Warsz). 2012 Nov;71(4):252-62.


PMID- 23196892
OWN - NLM
STAT- MEDLINE
DCOM- 20131218
LR  - 20211021
IS  - 1432-1262 (Electronic)
IS  - 0179-1958 (Linking)
VI  - 28
IP  - 6
DP  - 2013 Jun
TI  - Randomised clinical trial of pilonidal sinus operations performed in the prone
      position under spinal anaesthesia with hyperbaric bupivacaine 0.5 % versus total 
      intravenous anaesthesia.
PG  - 873-80
LID - 10.1007/s00384-012-1619-z [doi]
AB  - PURPOSE: The aim of this randomised clinical trial was to determine whether
      spinal anaesthesia (SPA) is superior to total intravenous anaesthesia (TIVA) in
      patients undergoing pilonidal sinus (PS) operations in the prone position.
      METHODS: After approval of the local ethics committee, suitable patients aged
      19-49 years were randomised to SPA (7.5 mg hyperbaric bupivacaine) or TIVA
      (Propofol and Fentanyl). Cumulative consumption of analgesics, postoperative
      recovery, complications and patient satisfaction were evaluated. RESULTS: A total
      of 50 patients were randomised within a 24-month period. Median monitoring time
      in the recovery room was 0 (0-11) min for SPA versus 40 (5-145) min for TIVA (p <
      0.0001). Patients in the SPA group were able to drink (40.5 (0-327) min versus
      TIVA 171 (72-280) min, p < 0.0001) and eat (55 (0-333) min versus TIVA 220
      (85-358), p < 0.0001) earlier. More patients with a TIVA needed analgesics in the
      recovery room (SPA n = 0 versus TIVA n = 6, p = 0.0023) and suffered more
      frequently from a sore throat (SPA n = 0 versus TIVA n = 11, p = 0.0001). Two
      patients with a TIVA suffered from nausea and vomiting. Patients of both groups
      were equally satisfied with the anaesthesia technique offered. CONCLUSIONS: SPA
      with 7.5 mg hyperbaric bupivacaine is superior to TIVA in patients undergoing PS 
      operations in the prone position in terms of analgesia consumption in the
      recovery room, recovery times and postoperative complications.
FAU - Schmittner, Marc D
AU  - Schmittner MD
AD  - Department of Anaesthesiology and Surgical Intensive Care Medicine, University
      Medical Centre Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
      marc.schmittner@umm.de
FAU - Dieterich, Sven
AU  - Dieterich S
FAU - Gebhardt, Volker
AU  - Gebhardt V
FAU - Weiss, Christel
AU  - Weiss C
FAU - Burmeister, Marc A
AU  - Burmeister MA
FAU - Bussen, Dieter G
AU  - Bussen DG
FAU - Viergutz, Tim
AU  - Viergutz T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20121130
PL  - Germany
TA  - Int J Colorectal Dis
JT  - International journal of colorectal disease
JID - 8607899
RN  - 0 (Analgesics)
RN  - UF599785JZ (Fentanyl)
RN  - Y8335394RO (Bupivacaine)
RN  - YI7VU623SF (Propofol)
SB  - IM
MH  - Adult
MH  - Analgesics/administration & dosage/pharmacology
MH  - Anesthesia Recovery Period
MH  - *Anesthesia, Intravenous/adverse effects
MH  - *Anesthesia, Spinal/adverse effects
MH  - Bupivacaine/administration & dosage/*pharmacology
MH  - Demography
MH  - Female
MH  - Fentanyl/administration & dosage/pharmacology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Block
MH  - Patient Satisfaction
MH  - Pilonidal Sinus/*surgery
MH  - Postoperative Care
MH  - Prone Position
MH  - Propofol/administration & dosage/pharmacology
MH  - Recovery Room
MH  - Young Adult
EDAT- 2012/12/01 06:00
MHDA- 2013/12/19 06:00
CRDT- 2012/12/01 06:00
PHST- 2012/11/21 00:00 [accepted]
PHST- 2012/12/01 06:00 [entrez]
PHST- 2012/12/01 06:00 [pubmed]
PHST- 2013/12/19 06:00 [medline]
AID - 10.1007/s00384-012-1619-z [doi]
PST - ppublish
SO  - Int J Colorectal Dis. 2013 Jun;28(6):873-80. doi: 10.1007/s00384-012-1619-z. Epub
      2012 Nov 30.


PMID- 23196449
OWN - NLM
STAT- MEDLINE
DCOM- 20140421
LR  - 20190918
IS  - 1882-0654 (Electronic)
IS  - 0009-918X (Linking)
VI  - 52
IP  - 11
DP  - 2012
TI  - [Series of clinical ethics necessary for neurological medicine -"bad news
      telling" with a focus on notification of intractable diseases].
PG  - 877
FAU - Ogino, Mieko
AU  - Ogino M
AD  - Kitasato University, School of Medicine, Department of Neurology.
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Rinsho Shinkeigaku
JT  - Rinsho shinkeigaku = Clinical neurology
JID - 0417466
SB  - IM
MH  - Humans
MH  - *Neurodegenerative Diseases
MH  - Truth Disclosure/*ethics
EDAT- 2012/12/01 06:00
MHDA- 2014/04/22 06:00
CRDT- 2012/12/01 06:00
PHST- 2012/12/01 06:00 [entrez]
PHST- 2012/12/01 06:00 [pubmed]
PHST- 2014/04/22 06:00 [medline]
AID - DN/JST.JSTAGE/clinicalneurol/52.877 [pii]
AID - 10.5692/clinicalneurol.52.877 [doi]
PST - ppublish
SO  - Rinsho Shinkeigaku. 2012;52(11):877. doi: 10.5692/clinicalneurol.52.877.


PMID- 23195710
OWN - NLM
STAT- MEDLINE
DCOM- 20130627
LR  - 20191210
IS  - 1095-8304 (Electronic)
IS  - 0195-6663 (Linking)
VI  - 62
DP  - 2013 Mar
TI  - When good deeds leave a bad taste. Negative inferences from ethical food claims.
PG  - 76-83
LID - 10.1016/j.appet.2012.11.004 [doi]
LID - S0195-6663(12)00447-3 [pii]
AB  - Consumer research has demonstrated halo effects arising from advertising claims
      on food packaging (e.g., "organic," "no cholesterol") that promote misperceiving 
      products more positively on other dimensions (e.g., low-calorie, low-fat).
      However, little research has explored the conditions under which such claims
      might give rise to more negative rather than positive evaluations. This paper
      highlights two domains of judgment in which an ethical or values-based claim
      ("organic") can promote negative impressions. In Study 1, participants judged
      organic foods relative to conventional foods on healthfulness and expected taste 
      quality. Results suggest that whereas organics are perceived as more healthful
      than conventional foods (consistent with previous findings), they are also
      perceived as less tasty, especially among participants low in environmental
      concern. In Study 2, participants judged the effectiveness of a formula drink
      intended to help alleviate malnourishment that was described as organic or not,
      depending on experimental condition. Results showed that participants high in
      environmental concern (who typically evaluate organic products positively) judged
      the drink more negatively (i.e., as less effective) when it was described as
      "organic." Discussion focuses on possible mechanisms for these effects, as well
      as the moderating role of judgment type and perceivers' values in halo effects
      more broadly.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Schuldt, Jonathon P
AU  - Schuldt JP
AD  - Department of Communication, Cornell University, Ithaca, NY 14853, United States.
      jps56@cornell.edu
FAU - Hannahan, Mary
AU  - Hannahan M
LA  - eng
PT  - Journal Article
DEP - 20121126
PL  - England
TA  - Appetite
JT  - Appetite
JID - 8006808
SB  - IM
MH  - Advertising
MH  - Attitude to Health
MH  - Beverages
MH  - Diet/ethics/*psychology
MH  - Environment
MH  - Female
MH  - *Food Labeling
MH  - *Food, Organic
MH  - *Health
MH  - Humans
MH  - *Judgment
MH  - Male
MH  - Malnutrition
MH  - Nutritive Value
MH  - *Perception
MH  - Social Values
MH  - *Taste
EDAT- 2012/12/01 06:00
MHDA- 2013/06/29 06:00
CRDT- 2012/12/01 06:00
PHST- 2012/08/07 00:00 [received]
PHST- 2012/10/13 00:00 [revised]
PHST- 2012/11/11 00:00 [accepted]
PHST- 2012/12/01 06:00 [entrez]
PHST- 2012/12/01 06:00 [pubmed]
PHST- 2013/06/29 06:00 [medline]
AID - S0195-6663(12)00447-3 [pii]
AID - 10.1016/j.appet.2012.11.004 [doi]
PST - ppublish
SO  - Appetite. 2013 Mar;62:76-83. doi: 10.1016/j.appet.2012.11.004. Epub 2012 Nov 26.


PMID- 23195413
OWN - NLM
STAT- MEDLINE
DCOM- 20131115
LR  - 20211203
IS  - 1875-7855 (Electronic)
IS  - 0079-6123 (Linking)
VI  - 200
DP  - 2012
TI  - Ethical challenges for using human cells in clinical cell therapy.
PG  - 17-40
LID - 10.1016/B978-0-444-59575-1.00002-8 [doi]
LID - B978-0-444-59575-1.00002-8 [pii]
AB  - In this chapter, different challenges for using human cells in clinical cell
      therapy are identified and discussed. Several types of challenges are defined and
      described, with particular attention to the relation between ethical and
      scientific challenges. Some challenges are cell and disease specific: they are
      raised by research on special types of cells with certain methods in order to
      pave the way for cell therapies of particular diseases. But since scientific work
      is carried out in a societal and value-loaded context, the relations between
      scientific, ethical, and regulatory challenges are complex. Three theses are
      first discussed: there is not one fixed list of ethical challenges, some
      challenges are disease and cell type specific; there are challenges at all stages
      of the translation from bench to bedside, and the challenges are related to the
      various stages of translation. Moreover, experimental and ethical research needs 
      to be integrated. Finally, a fourth thesis is suggested: if a constructive and
      well-argued position is desired, it is necessary to be specific not only about
      the scientific details but also about the value premises. Everybody is for
      justice, integrity, and respect for persons. But what precisely does this mean
      when it is applied to the choices scientists and regulators have to face in their
      daily work?
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Hermeren, Goran
AU  - Hermeren G
AD  - Department of Medical Ethics, Biomedial Center, Lund University, Lund, Sweden.
      goran.hermeren@med.lu.se
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Prog Brain Res
JT  - Progress in brain research
JID - 0376441
SB  - IM
MH  - Animals
MH  - Cell- and Tissue-Based Therapy/economics/*ethics/methods
MH  - Humans
MH  - Nervous System Diseases/surgery
MH  - Translational Research, Biomedical/economics/*ethics/methods
EDAT- 2012/12/01 06:00
MHDA- 2013/11/16 06:00
CRDT- 2012/12/01 06:00
PHST- 2012/12/01 06:00 [entrez]
PHST- 2012/12/01 06:00 [pubmed]
PHST- 2013/11/16 06:00 [medline]
AID - B978-0-444-59575-1.00002-8 [pii]
AID - 10.1016/B978-0-444-59575-1.00002-8 [doi]
PST - ppublish
SO  - Prog Brain Res. 2012;200:17-40. doi: 10.1016/B978-0-444-59575-1.00002-8.


PMID- 23195292
OWN - NLM
STAT- MEDLINE
DCOM- 20130821
LR  - 20161229
IS  - 1879-3479 (Electronic)
IS  - 0020-7292 (Linking)
VI  - 120
IP  - 3
DP  - 2013 Mar
TI  - Ethical issues in the management of severe congenital anomalies.
PG  - 307-8
LID - 10.1016/j.ijgo.2012.10.005 [doi]
LID - S0020-7292(12)00517-6 [pii]
CN  - Figo Committee for Ethical Aspects of Human Reproduction and Women's Health
LA  - eng
PT  - Journal Article
DEP - 20121126
PL  - United States
TA  - Int J Gynaecol Obstet
JT  - International journal of gynaecology and obstetrics: the official organ of the
      International Federation of Gynaecology and Obstetrics
JID - 0210174
SB  - IM
MH  - Abortion, Legal/*ethics
MH  - Congenital Abnormalities/diagnosis/*therapy
MH  - Ethics Committees, Clinical
MH  - Female
MH  - Humans
MH  - Practice Guidelines as Topic
MH  - Pregnancy
MH  - *Pregnancy Complications
MH  - Prenatal Diagnosis
EDAT- 2012/12/01 06:00
MHDA- 2013/08/22 06:00
CRDT- 2012/12/01 06:00
PHST- 2012/12/01 06:00 [entrez]
PHST- 2012/12/01 06:00 [pubmed]
PHST- 2013/08/22 06:00 [medline]
AID - S0020-7292(12)00517-6 [pii]
AID - 10.1016/j.ijgo.2012.10.005 [doi]
PST - ppublish
SO  - Int J Gynaecol Obstet. 2013 Mar;120(3):307-8. doi: 10.1016/j.ijgo.2012.10.005.
      Epub 2012 Nov 26.


PMID- 23195290
OWN - NLM
STAT- MEDLINE
DCOM- 20130821
LR  - 20161229
IS  - 1879-3479 (Electronic)
IS  - 0020-7292 (Linking)
VI  - 120
IP  - 3
DP  - 2013 Mar
TI  - Ethical aspects of HIV infection and reproduction.
PG  - 309
LID - 10.1016/j.ijgo.2012.10.006 [doi]
LID - S0020-7292(12)00565-6 [pii]
CN  - FIGO Committee for Ethical Aspects of Human Reproduction and Women's Health
LA  - eng
PT  - Journal Article
DEP - 20121127
PL  - United States
TA  - Int J Gynaecol Obstet
JT  - International journal of gynaecology and obstetrics: the official organ of the
      International Federation of Gynaecology and Obstetrics
JID - 0210174
SB  - IM
MH  - Breast Feeding/ethics
MH  - Confidentiality/ethics
MH  - Ethics Committees, Clinical
MH  - Female
MH  - *HIV
MH  - HIV Infections/*prevention & control/transmission
MH  - Humans
MH  - Pregnancy
MH  - *Pregnancy Complications, Infectious
MH  - Reproductive Techniques, Assisted/*ethics
MH  - Truth Disclosure/*ethics
EDAT- 2012/12/01 06:00
MHDA- 2013/08/22 06:00
CRDT- 2012/12/01 06:00
PHST- 2012/12/01 06:00 [entrez]
PHST- 2012/12/01 06:00 [pubmed]
PHST- 2013/08/22 06:00 [medline]
AID - S0020-7292(12)00565-6 [pii]
AID - 10.1016/j.ijgo.2012.10.006 [doi]
PST - ppublish
SO  - Int J Gynaecol Obstet. 2013 Mar;120(3):309. doi: 10.1016/j.ijgo.2012.10.006. Epub
      2012 Nov 27.


PMID- 23195286
OWN - NLM
STAT- MEDLINE
DCOM- 20130806
LR  - 20161229
IS  - 1879-3479 (Electronic)
IS  - 0020-7292 (Linking)
VI  - 120
IP  - 2
DP  - 2013 Feb
TI  - Ethical guidelines on cord blood banking.
PG  - 208-9
LID - 10.1016/j.ijgo.2012.10.003 [doi]
LID - S0020-7292(12)00515-2 [pii]
CN  - FIGO Committee for the Ethical Aspects of Human Reproduction and Women's Health
LA  - eng
PT  - Consensus Development Conference
PT  - Journal Article
DEP - 20121127
PL  - United States
TA  - Int J Gynaecol Obstet
JT  - International journal of gynaecology and obstetrics: the official organ of the
      International Federation of Gynaecology and Obstetrics
JID - 0210174
SB  - IM
MH  - Blood Banks/economics/*ethics
MH  - Female
MH  - *Fetal Blood
MH  - Humans
MH  - Pregnancy
EDAT- 2012/12/01 06:00
MHDA- 2013/08/07 06:00
CRDT- 2012/12/01 06:00
PHST- 2012/12/01 06:00 [entrez]
PHST- 2012/12/01 06:00 [pubmed]
PHST- 2013/08/07 06:00 [medline]
AID - S0020-7292(12)00515-2 [pii]
AID - 10.1016/j.ijgo.2012.10.003 [doi]
PST - ppublish
SO  - Int J Gynaecol Obstet. 2013 Feb;120(2):208-9. doi: 10.1016/j.ijgo.2012.10.003.
      Epub 2012 Nov 27.


PMID- 23195275
OWN - NLM
STAT- MEDLINE
DCOM- 20130320
LR  - 20181202
IS  - 1873-4502 (Electronic)
IS  - 0886-3350 (Linking)
VI  - 38
IP  - 12
DP  - 2012 Dec
TI  - Ethical responsibility to disclose surgical errors.
PG  - 2209-10; author reply 2210
LID - 10.1016/j.jcrs.2012.10.004 [doi]
LID - S0886-3350(12)01383-1 [pii]
FAU - Blomquist, Preston H
AU  - Blomquist PH
LA  - eng
PT  - Letter
PT  - Comment
PL  - United States
TA  - J Cataract Refract Surg
JT  - Journal of cataract and refractive surgery
JID - 8604171
SB  - IM
CON - J Cataract Refract Surg. 2012 Aug;38(8):1499-501. PMID: 22814059
MH  - Humans
MH  - *Lens Implantation, Intraocular
MH  - *Lenses, Intraocular
MH  - Male
MH  - *Medical Errors
MH  - Myopia/*surgery
MH  - *Phacoemulsification
EDAT- 2012/12/01 06:00
MHDA- 2013/03/21 06:00
CRDT- 2012/12/01 06:00
PHST- 2012/08/03 00:00 [received]
PHST- 2012/12/01 06:00 [entrez]
PHST- 2012/12/01 06:00 [pubmed]
PHST- 2013/03/21 06:00 [medline]
AID - S0886-3350(12)01383-1 [pii]
AID - 10.1016/j.jcrs.2012.10.004 [doi]
PST - ppublish
SO  - J Cataract Refract Surg. 2012 Dec;38(12):2209-10; author reply 2210. doi:
      10.1016/j.jcrs.2012.10.004.


PMID- 23194956
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130101
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 6
DP  - 2012
TI  - Prophylactic antibiotic regimens in tumour surgery (PARITY): protocol for a
      multicentre randomised controlled study.
LID - 10.1136/bmjopen-2012-002197 [doi]
LID - e002197 [pii]
AB  - INTRODUCTION: Limb salvage with endoprosthetic reconstruction is the standard of 
      care for the management of lower-extremity bone tumours in skeletally mature
      patients. The risk of deep postoperative infection in these procedures is high
      and the outcomes can be devastating. The most effective prophylactic antibiotic
      regimen remains unknown, and current clinical practice is highly varied. This
      trial will evaluate the effect of varying postoperative prophylactic antibiotic
      regimens on the incidence of deep infection following surgical excision and
      endoprosthetic reconstruction of lower-extremity bone tumours. METHODS AND
      ANALYSIS: This is a multicentre, blinded, randomised controlled trial, using a
      parallel two-arm design. 920 patients 15 years of age or older from 12 tertiary
      care centres across Canada and the USA who are undergoing surgical excision and
      endoprosthetic reconstruction of a primary bone tumour will receive either short 
      (24 h) or long (5 days) duration postoperative antibiotics. Exclusion criteria
      include prior surgery or infection within the planned operative field, known
      colonisation with methicillin-resistant Staphylococcus aureus or
      vancomycin-resistant Enterococcus at enrolment, or allergy to the study
      antibiotics. The primary outcome will be rates of deep postoperative infections
      in each arm. Secondary outcomes will include type and frequency of
      antibiotic-related adverse events, patient functional outcomes and
      quality-of-life scores, reoperation and mortality. Randomisation will be blocked,
      with block sizes known only to the methods centre responsible for randomisation, 
      and stratified by location of tumour and study centre. Patients, care givers and 
      a Central Adjudication Committee will be blinded to treatment allocation. The
      analysis to compare groups will be performed using Cox regression and log-rank
      tests to compare survival functions at alpha=0.05. ETHICS AND DISSEMINATION: This
      study has ethics approval from the McMaster University/Hamilton Health Sciences
      Research Ethics Board (REB# 12-009). Successful completion will significantly
      impact on clinical practice and enhance patients' lives. More broadly, this trial
      will develop a network of collaboration from which further high-quality trials in
      Orthopaedic Oncology will follow.
FAU - Ghert, Michelle
AU  - Ghert M
AD  - Division of Orthopaedic Surgery, Department of Surgery, McMaster University,
      Hamilton, Ontario, Canada.
FAU - Deheshi, Benjamin
AU  - Deheshi B
FAU - Holt, Ginger
AU  - Holt G
FAU - Randall, R Lor
AU  - Randall RL
FAU - Ferguson, Peter
AU  - Ferguson P
FAU - Wunder, Jay
AU  - Wunder J
FAU - Turcotte, Robert
AU  - Turcotte R
FAU - Werier, Joel
AU  - Werier J
FAU - Clarkson, Paul
AU  - Clarkson P
FAU - Damron, Timothy
AU  - Damron T
FAU - Benevenia, Joseph
AU  - Benevenia J
FAU - Anderson, Megan
AU  - Anderson M
FAU - Gebhardt, Mark
AU  - Gebhardt M
FAU - Isler, Marc
AU  - Isler M
FAU - Mottard, Sophie
AU  - Mottard S
FAU - Healey, John
AU  - Healey J
FAU - Evaniew, Nathan
AU  - Evaniew N
FAU - Racano, Antonella
AU  - Racano A
FAU - Sprague, Sheila
AU  - Sprague S
FAU - Swinton, Marilyn
AU  - Swinton M
FAU - Bryant, Dianne
AU  - Bryant D
FAU - Thabane, Lehana
AU  - Thabane L
FAU - Guyatt, Gordon
AU  - Guyatt G
FAU - Bhandari, Mohit
AU  - Bhandari M
CN  - PARITY Investigators
LA  - eng
PT  - Journal Article
DEP - 20121128
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3533099
EDAT- 2012/12/01 06:00
MHDA- 2012/12/01 06:01
CRDT- 2012/12/01 06:00
PHST- 2012/12/01 06:00 [entrez]
PHST- 2012/12/01 06:00 [pubmed]
PHST- 2012/12/01 06:01 [medline]
AID - bmjopen-2012-002197 [pii]
AID - 10.1136/bmjopen-2012-002197 [doi]
PST - epublish
SO  - BMJ Open. 2012 Nov 28;2(6). pii: bmjopen-2012-002197. doi:
      10.1136/bmjopen-2012-002197. Print 2012.


PMID- 23193799
OWN - NLM
STAT- MEDLINE
DCOM- 20121231
LR  - 20121130
IS  - 2282-2593 (Print)
IS  - 2282-2593 (Linking)
VI  - 105
IP  - 1
DP  - 2012
TI  - Pain in veterinary medicine in the new millennium.
PG  - 77-85
AB  - The practice of veterinary medicine has changed radically over the past two
      decades, new technology and scientific breakthroughs have occurred, in close
      association with the field of human medicine. This progress has not only
      increased the capacity of veterinarians to provide high-quality care, it has also
      served to increase client awareness and expectations regarding animal care. On
      the legal front, it has finally given a "voice" to animals, now defined as
      sentient beings, thus imposing a series of duties upon veterinarians to promote
      their welfare. Preventing and managing pain has become a fundamental element of
      patient care quality in veterinary medicine, and pharmacotherapy is the basis of 
      pain management. This paper takes this as a starting point to clarify the concept
      of pain in veterinary medicine and explores the relevance of an ethic to the
      clinical setting which gives the animal patient a strong right to freedom from
      unnecessary pain and thus creating moral obligations towards patients on the part
      of veterinary professionals. There is the duty not to inflict pain and suffering 
      beyond what is necessary for effective diagnosis and treatment on the one hand
      and a duty to do all that can be done to relieve all the pain and suffering which
      can be alleviated on the other.
FAU - Passantino, Annamaria
AU  - Passantino A
AD  - Department of Veterinary Public Health, Faculty of Veterinary Medicine Polo
      Universitario Annunziata, 98168 Messina, Italy. passanna@unime.it
FAU - Fazio, Alessandra
AU  - Fazio A
FAU - Quartatone, Valeria
AU  - Quartatone V
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Theor Biol Forum
JT  - Theoretical biology forum
JID - 101570881
SB  - IM
MH  - Animals
MH  - Forecasting
MH  - Pain/*prevention & control
MH  - Pain Management/*ethics
MH  - Practice Guidelines as Topic
MH  - Veterinary Medicine/*ethics/*trends
EDAT- 2012/12/01 06:00
MHDA- 2013/01/01 06:00
CRDT- 2012/12/01 06:00
PHST- 2012/12/01 06:00 [entrez]
PHST- 2012/12/01 06:00 [pubmed]
PHST- 2013/01/01 06:00 [medline]
PST - ppublish
SO  - Theor Biol Forum. 2012;105(1):77-85.


PMID- 29147317
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220310
IS  - 1920-454X (Electronic)
IS  - 1920-4531 (Linking)
VI  - 3
IP  - 6
DP  - 2012 Dec
TI  - Maintenance Chemotherapy Use for Advanced Non-Small Cell Lung Cancer in an
      Australian Cancer Centre.
PG  - 264-270
LID - 10.4021/wjon590w [doi]
AB  - BACKGROUND: To investigate the rates of maintenance therapy in advanced non-small
      cell cancer, the reasons for not progressing to second line therapy at disease
      progression at our cancer centre and to use this data as a way to institute it
      into clinical practice in our cancer centre. METHOD: This study was approved by
      the ethics committee. The data was collected from a purpose built cancer unit
      database, patient and pharmacy records for all patients diagnosed with Stage 3
      and 4 non-small cell lung cancer between 2005 - 2011. Demographic information was
      collected and subgroup analysis of mean overall survival was obtained. Reasons
      for not progressing to second line therapy were also analysed. RESULTS: Of the
      105 patients available for analysis, 44 achieved stable disease/partial response 
      (SD/PR) post first cycle of which 42 were eligible for maintenance chemotherapy, 
      7 went onto receive maintenance with a mean overall survival (OS) of 18.26
      months, 23 received second line with the highest OS of 28.19 months and 12 didn't
      receive either with the lowest OS of 11.52 months. The majority of these patients
      did not receive second line at disease progression because of being too unwell.
      CONCLUSION: Similar data on the progression to second line chemotherapy in this
      patient group was seen. Those that received second line chemotherapy had higher
      overall survival and thus maintenance therapy could be a means to allow patients 
      to be fit enough to receive second line when they need it.
FAU - Wann, Alysson
AU  - Wann A
AD  - St Vincent's Hospital, 41 Victoria St, Fitzroy, Victoria 3065, Australia.
FAU - Newnham, Genni
AU  - Newnham G
AD  - St Vincent's Hospital, 41 Victoria St, Fitzroy, Victoria 3065, Australia.
LA  - eng
PT  - Journal Article
DEP - 20130104
PL  - Canada
TA  - World J Oncol
JT  - World journal of oncology
JID - 101564097
PMC - PMC5649804
OTO - NOTNLM
OT  - Australia
OT  - Maintenance
OT  - NSCLC
OT  - Outcomes
OT  - Therapy
EDAT- 2012/12/01 00:00
MHDA- 2012/12/01 00:01
CRDT- 2017/11/18 06:00
PHST- 2012/12/11 00:00 [accepted]
PHST- 2017/11/18 06:00 [entrez]
PHST- 2012/12/01 00:00 [pubmed]
PHST- 2012/12/01 00:01 [medline]
AID - 10.4021/wjon590w [doi]
PST - ppublish
SO  - World J Oncol. 2012 Dec;3(6):264-270. doi: 10.4021/wjon590w. Epub 2013 Jan 4.


PMID- 26255388
OWN - NLM
STAT- MEDLINE
DCOM- 20150901
LR  - 20171116
IS  - 1373-4857 (Print)
IS  - 1373-4857 (Linking)
VI  - 18
IP  - 2
DP  - 2012 Dec
TI  - [The Paraphrasis of Vesalius in the Context of Latin Translations of Rhazes].
PG  - 83-8
AB  - In the 16th century, most students initiated their studies at the Faculty of Arts
      (or Liberal Arts), where the syllabus was not like one of today academic studies,
      rather, it was closer to a grammar school program of studies. This gave the
      students access to one of the three other Faculties: Theology, Law (civil and
      canonic) and Medicine. At Louvain University, the students could choose between
      four pedagogic programs, called 'Porc' [Porcus], 'Lily' [Lilium], 'Falcon'
      [Falco] and 'Castle' [Castrum]. The most appreciated topics were Philosophy,
      Logics, Physics, Metaphysics and Ethics. Aristotle was the most estimated author.
      However, Mathematics, Astronomy and Music were also on the syllabus. There were
      also a number of training exercises in Latin, as well as courses on Eloquence. In
      higher studies, there were also Disputationes and Quaestiones quodlibeticae,
      during which the students were supposed to vindicate their views and to answer
      the questions of their teachers and of their fellow-students. The academic
      language was Latin, without the knowledge of which nobody could register;
      moreover registration fees were required, as well as taking an Oath on being
      faithful to the statutes of the University.
FAU - Biesbrouck, Maurits
AU  - Biesbrouck M
FAU - Steeno, Omer
AU  - Steeno O
FAU - Vons, Jacqueline
AU  - Vons J
LA  - fre
PT  - Biography
PT  - Historical Article
PT  - Journal Article
TT  - La Paraphrasis de Vesale dans le Contexte des Traductions Latines de Rhazes.
PL  - Belgium
TA  - Vesalius
JT  - Vesalius : acta internationales historiae medicinae
JID - 9517855
MH  - *Curriculum
MH  - Europe
MH  - History, 16th Century
MH  - History, Medieval
MH  - Manuscripts, Medical as Topic/*history
MH  - *Translations
MH  - Universities/*history
PS  - Rhazes
FPS - Rhazes
PS  - Vesalius A
FPS - Vesalius, Andreas
EDAT- 2012/12/01 00:00
MHDA- 2015/09/02 06:00
CRDT- 2015/08/11 06:00
PHST- 2015/08/11 06:00 [entrez]
PHST- 2012/12/01 00:00 [pubmed]
PHST- 2015/09/02 06:00 [medline]
PST - ppublish
SO  - Vesalius. 2012 Dec;18(2):83-8.


PMID- 25207045
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140910
LR  - 20211021
IS  - 2146-3123 (Print)
IS  - 2146-3123 (Linking)
VI  - 29
IP  - 4
DP  - 2012 Dec
TI  - Glutamine supplemented parenteral nutrition to prevent ventilator-associated
      pneumonia in the intensive care unit.
PG  - 414-8
LID - 10.5152/balkanmedj.2012.043 [doi]
AB  - OBJECTIVE: Ventilator-associated pneumonia (VAP) is a form of nosocomial
      pneumonia that increases patient morbidity and mortality, length of hospital
      stay, and healthcare costs. Glutamine preserves the intestinal mucosal structure,
      increases immune function, and reduces harmful changes in gut permeability in
      patients receiving total parenteral nutrition (TPN). We hypothesized that TPN
      supplemented by glutamine might prevent the development of VAP in patients on
      mechanical ventilator support in the intensive care unit (ICU). MATERIAL AND
      METHODS: With the approval of the ethics committee and informed consent from
      relatives, 60 patients who were followed in the ICU with mechanical ventilator
      support were included in our study. Patients were divided into three groups. The 
      first group received enteral nutrition (n=20), and the second was prescribed TPN 
      (n=20) while the third group was given glutamine-supplemented TPN (n=20).
      C-reactive protein (CRP), sedimentation rate, body temperature, development of
      purulent secretions, increase in the amount of secretions, changes in the
      characteristics of secretions and an increase in requirement of deep tracheal
      aspiration were monitored for seven days by daily examination and radiographs.
      RESULTS: No statistically significant difference was found among groups in terms 
      of development of VAP (p=0.622). CONCLUSION: Although VAP developed at a lower
      rate in the glutamine-supplemented TPN group, no statistically significant
      difference was found among any of the groups. Glutamine-supplemented TPN may have
      no superiority over unsupplemented enteral and TPN in preventing VAP.
FAU - Aydogmus, Meltem Turkay
AU  - Aydogmus MT
AD  - Department of Anesthesiology and Reanimation, Faculty of Medicine, Yuzuncu Yil
      University, Van, Turkey.
FAU - Tomak, Yakup
AU  - Tomak Y
AD  - Department of Anesthesiology and Reanimation, Faculty of Medicine, Rize
      University, Rize, Turkey.
FAU - Tekin, Murat
AU  - Tekin M
AD  - Department of Anesthesiology and Reanimation, Faculty of Medicine, Yuzuncu Yil
      University, Van, Turkey.
FAU - Kati, Ismail
AU  - Kati I
AD  - Department of Anesthesiology and Reanimation, Faculty of Medicine, Yuzuncu Yil
      University, Van, Turkey.
FAU - Huseyinoglu, Urfettin
AU  - Huseyinoglu U
AD  - Department of Anesthesiology and Reanimation, Faculty of Medicine, Yuzuncu Yil
      University, Van, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20121201
PL  - Turkey
TA  - Balkan Med J
JT  - Balkan medical journal
JID - 101571817
PMC - PMC4115876
OTO - NOTNLM
OT  - Nutritional support
OT  - glutamine
OT  - ventilator-associated pneumonia
EDAT- 2012/12/01 00:00
MHDA- 2012/12/01 00:01
CRDT- 2014/09/11 06:00
PHST- 2012/03/02 00:00 [received]
PHST- 2012/05/30 00:00 [accepted]
PHST- 2014/09/11 06:00 [entrez]
PHST- 2012/12/01 00:00 [pubmed]
PHST- 2012/12/01 00:01 [medline]
AID - 10.5152/balkanmedj.2012.043 [doi]
AID - bmj-29-4-414 [pii]
PST - ppublish
SO  - Balkan Med J. 2012 Dec;29(4):414-8. doi: 10.5152/balkanmedj.2012.043. Epub 2012
      Dec 1.


PMID- 24868114
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20211021
IS  - 0860-021X (Print)
IS  - 0860-021X (Linking)
VI  - 29
IP  - 4
DP  - 2012 Dec
TI  - Does aerobic exercise training promote changes in structural and biomechanical
      properties of the tendons in experimental animals? A systematic review.
PG  - 249-54
LID - 10.5604/20831862.1019661 [doi]
AB  - To develop a systematic review to evaluate, through the best scientific evidence 
      available, the effectiveness of aerobic exercise in improving the biomechanical
      characteristics of tendons in experimental animals. Two independent assessors
      conducted a systematic search in the databases Medline/PUBMED and Lilacs/BIREME, 
      using the following descriptors of Mesh in animal models. The ultimate load of
      traction and the elastic modulus tendon were used as primary outcomes and
      transverse section area, ultimate stress and tendon strain as secondary outcomes.
      The assessment of risk of bias in the studies was carried out using the following
      methodological components: light/dark cycle, temperature, nutrition, housing,
      research undertaken in conjunction with an ethics committee, randomization,
      adaptation of the animals to the training and preparation for the mechanical
      test. Eight studies, comprising 384 animals, were selected; it was not possible
      to combine them into one meta-analysis due to the heterogeneity of the samples.
      There was a trend to increasing ultimate load without changes in the other
      outcomes studied. Only one study met more than 80% of the quality criteria.
      Physical training performed in a structured way with imposition of overloads
      seems to be able to promote changes in tendon structure of experimental models by
      increasing the ultimate load supported. However, the results of the influence of 
      exercise on the elastic modulus parameters, strain, transverse section area and
      ultimate stress, remain controversial and inconclusive. Such a conclusion must be
      evaluated with reservation as there was low methodological control in the studies
      included in this review.
FAU - Bezerra, M A
AU  - Bezerra MA
AD  - Master in Physiotherapy. Federal University of Pernambuco - UFPE, Brazil.
FAU - Lemos, A
AU  - Lemos A
AD  - Physiotherapy Department of the Federal University of Pernambuco - UFPE, Brazil.
FAU - Lira, K D S
AU  - Lira KD
AD  - Master in Physiotherapy. Federal University of Pernambuco - UFPE, Brazil.
FAU - Silveira, P V C
AU  - Silveira PV
AD  - Master in Physiotherapy. Federal University of Pernambuco - UFPE, Brazil.
FAU - Coutinho, M P G
AU  - Coutinho MP
AD  - Federal University of Pernambuco - UFPE, Brazil.
FAU - E Moraes, S R A
AU  - E Moraes SR
AD  - Anatomy Department of the Federal University of Pernambuco - UFPE, Brazil.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121115
PL  - Poland
TA  - Biol Sport
JT  - Biology of sport
JID - 8700872
PMC - PMC4033057
OTO - NOTNLM
OT  - aerobic exercise
OT  - animals
OT  - biomechanics
OT  - systematic reviews
EDAT- 2012/12/01 00:00
MHDA- 2012/12/01 00:01
CRDT- 2014/05/29 06:00
PHST- 2012/07/18 00:00 [accepted]
PHST- 2014/05/29 06:00 [entrez]
PHST- 2012/12/01 00:00 [pubmed]
PHST- 2012/12/01 00:01 [medline]
AID - 10.5604/20831862.1019661 [doi]
AID - 1019661 [pii]
PST - ppublish
SO  - Biol Sport. 2012 Dec;29(4):249-54. doi: 10.5604/20831862.1019661. Epub 2012 Nov
      15.


PMID- 24845136
OWN - NLM
STAT- MEDLINE
DCOM- 20150109
LR  - 20160511
IS  - 1947-5543 (Electronic)
IS  - 1947-5543 (Linking)
VI  - 10
IP  - 6
DP  - 2012 Dec
TI  - An online tool for improving biospecimen data element reporting.
PG  - 501-10
LID - 10.1089/bio.2012.0033 [doi]
AB  - Detailed documentation of the experimental materials and methods is essential for
      the validation of scientific papers. Human biospecimens are increasingly utilized
      as materials in cancer research and information about the biospecimens used is a 
      component of this documentation. We hypothesized that previously reported
      biospecimen data are inadequate for accurate replication and/or validation of a
      substantial proportion of studies. To examine this issue, we analyzed biospecimen
      reporting in a representative cross section of publications over the past 12
      years (1998, 2004, 2010) in the journals, Cancer Research (CR, n=46) and Clinical
      Cancer Research (CCR, n=73). We assessed biospecimen data in relation to the
      standards outlined as the Tier 1 recommended data elements from the Biospecimen
      Reporting for Improved Study Quality (BRISQ), in addition to ethics criteria.
      These data elements encompass features of biospecimens influenced by the patient,
      medical procedure, and biospecimen acquisition, handling and storage processes.
      Analysis found that while there was a significant increase in the reporting of
      ethics board approval status (p<0.008) and name of the ethics board (p<0.0001),
      there were no significant differences between these journals or over this period 
      in reporting other biospecimen-related data elements. Of the 15 Tier 1 data
      elements assessed in CR and CCR, the data elements commonly obtained from the
      "Clinical Chart" (8/15 elements) were significantly better reported than elements
      that would typically be obtained from the "Biobank" (p<0.0001). Our findings
      demonstrate that reporting of biospecimen-related data elements has been
      incomplete. As one part of the solution to this issue, we propose the use of an
      online data-elements reporting tool (www.biobanking.ca) by biobanks. This BRISQ
      Report tool aims to help biobanks provide the relevant biospecimen-related data
      as a structured report, and to promote its inclusion as supplementary material in
      publications to improve the quality of future research studies.
FAU - Cheah, Stefanie
AU  - Cheah S
AD  - 1 BC BioLibrary, British Columbia, Canada .
FAU - Dee, Simon
AU  - Dee S
FAU - Cole, Alexandra
AU  - Cole A
FAU - Matzke, Lise
AU  - Matzke L
FAU - O'Donoghue, Sheila
AU  - O'Donoghue S
FAU - Watson, Peter H
AU  - Watson PH
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Biopreserv Biobank
JT  - Biopreservation and biobanking
JID - 101507284
SB  - IM
MH  - *Biological Specimen Banks
MH  - Biomedical Research
MH  - Canada
MH  - Humans
MH  - Neoplasms/*pathology
MH  - Research Design/*standards/statistics & numerical data
MH  - Web Browser/*standards
EDAT- 2012/12/01 00:00
MHDA- 2015/01/13 06:00
CRDT- 2014/05/22 06:00
PHST- 2014/05/22 06:00 [entrez]
PHST- 2012/12/01 00:00 [pubmed]
PHST- 2015/01/13 06:00 [medline]
AID - 10.1089/bio.2012.0033 [doi]
PST - ppublish
SO  - Biopreserv Biobank. 2012 Dec;10(6):501-10. doi: 10.1089/bio.2012.0033.


PMID- 24845134
OWN - NLM
STAT- MEDLINE
DCOM- 20150109
LR  - 20160511
IS  - 1947-5543 (Electronic)
IS  - 1947-5543 (Linking)
VI  - 10
IP  - 6
DP  - 2012 Dec
TI  - Ovaries on ice: freezing fertility in preadolescent female cancer patients.
PG  - 485-92
LID - 10.1089/bio.2012.0024 [doi]
AB  - As survival rates from childhood cancer increase, fertility preservation is
      becoming increasingly important. Alkylating agents and whole body irradiation,
      common treatments in childhood cancer, have detrimental effects on follicle
      viability in females. Currently, ovarian tissue cryopreservation (OTC) is the
      only option for fertility preservation available to preadolescent females.
      Ovarian tissue can be harvested for cryopreservation laparoscopically without
      delaying cancer treatment. Although OTC is an experimental and rapidly evolving
      area of research, it has shown success in humans, with several live births
      reported thus far. Therefore, an analysis of OTC and its suitability for
      preadolescent females is appropriate at this time. Future research directions
      will allow OTC to transition from an experimental method with limited
      availability to a viable option for preadolescent cancer patients. As research
      progresses, physicians must be aware of the current state of OTC, as well as
      ethical concerns, risks, and benefits of OTC as a fertility preserving option.
FAU - Bellew, Elizabeth A
AU  - Bellew EA
AD  - 1 Georgetown University School of Medicine , Washington, District of Columbia.
FAU - Green, Deanna L
AU  - Green DL
FAU - Law, Emily W
AU  - Law EW
FAU - Rizzuto, Patrick J
AU  - Rizzuto PJ
FAU - McGaughey, Robert W
AU  - McGaughey RW
FAU - Gallicano, G Ian
AU  - Gallicano GI
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Biopreserv Biobank
JT  - Biopreservation and biobanking
JID - 101507284
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Cryopreservation/*methods
MH  - Female
MH  - Fertility Preservation/economics/ethics/*methods
MH  - Humans
MH  - Infant
MH  - Neoplasms/pathology/*surgery
MH  - Ovarian Follicle/transplantation
MH  - Ovary/*cytology
MH  - Tissue Preservation/methods
MH  - Tissue and Organ Harvesting
EDAT- 2012/12/01 00:00
MHDA- 2015/01/13 06:00
CRDT- 2014/05/22 06:00
PHST- 2014/05/22 06:00 [entrez]
PHST- 2012/12/01 00:00 [pubmed]
PHST- 2015/01/13 06:00 [medline]
AID - 10.1089/bio.2012.0024 [doi]
PST - ppublish
SO  - Biopreserv Biobank. 2012 Dec;10(6):485-92. doi: 10.1089/bio.2012.0024.


PMID- 24772384
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 2212-0661 (Print)
IS  - 2212-0661 (Linking)
VI  - 1
DP  - 2012 Dec 1
TI  - Participant-Centric Initiatives: Tools to Facilitate Engagement In Research.
PG  - 25-29
AB  - Clinical genomic research faces increasing challenges in establishing participant
      privacy and consent processes that facilitate meaningful choice and communication
      capacity for longitudinal and secondary research uses. There are an evolving
      range of participant-centric initiatives that combine web-based informatics tools
      with new models of engagement and research collaboration. These emerging
      initiatives may become valuable approaches to support large-scale and
      longitudinal research studies. We highlight and discuss four types of emerging
      initiatives for engaging and sustaining participation in research.
FAU - Anderson, Nicholas
AU  - Anderson N
AD  - Department of Biomedical Informatics and Medical Education, University of
      Washington ; Department of Bioethics and Humanities, University of Washington.
FAU - Bragg, Caleb
AU  - Bragg C
AD  - Applied Health Sciences, Wheaton College, Wheaton, IL.
FAU - Hartzler, Andrea
AU  - Hartzler A
AD  - Department of Biomedical Informatics and Medical Education, University of
      Washington.
FAU - Edwards, Kelly
AU  - Edwards K
AD  - Department of Bioethics and Humanities, University of Washington.
LA  - eng
GR  - P50 HG003374/HG/NHGRI NIH HHS/United States
GR  - UL1 RR025014/RR/NCRR NIH HHS/United States
GR  - UL1 TR000423/TR/NCATS NIH HHS/United States
PT  - Journal Article
PL  - Netherlands
TA  - Appl Transl Genom
JT  - Applied & translational genomics
JID - 101613235
PMC - PMC3998724
MID - NIHMS552565
OTO - NOTNLM
OT  - applied research
OT  - ethical and social issues
OT  - participant engagement
OT  - research communication
OT  - software tools
EDAT- 2012/12/01 00:00
MHDA- 2012/12/01 00:01
CRDT- 2014/04/29 06:00
PHST- 2014/04/29 06:00 [entrez]
PHST- 2012/12/01 00:00 [pubmed]
PHST- 2012/12/01 00:01 [medline]
AID - 10.1016/j.atg.2012.07.001 [doi]
AID - S2212-0661(12)00007-5 [pii]
PST - ppublish
SO  - Appl Transl Genom. 2012 Dec 1;1:25-29. doi: 10.1016/j.atg.2012.07.001.


PMID- 23370110
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140606
LR  - 20191112
IS  - 0104-5970 (Print)
IS  - 0104-5970 (Linking)
VI  - 19 Suppl 1
DP  - 2012 Dec
TI  - [A surgeon's fees in court (Vila Boa de Goias, 1801)].
PG  - 299-308
LID - S0104-59702012000500015 [pii]
AB  - The article explores the lawsuit brought by Surgeon-Major Andre Villela da Cunha 
      Roza against Joanna da Fonseca Coutinha in Vila Boa de Goias in 1801 to recover
      fees for his services. It examines the health care rendered to slaves, the
      scarcity and rising prices of these captives, the precarious training received by
      doctores and surgeons, and the ethical issues entailed in charging the fees in
      question.
FAU - Freitas, Lena Castello Branco Ferreira de
AU  - Freitas LC
AD  - Universidade Federal de Goias, Trindade, GO, Brasil, 75380-000,
      lenacastelo@uol.com.br.
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Honorarios de um cirurgiao na Justica (Vila Boa de Goias, 1801).
PL  - Brazil
TA  - Hist Cienc Saude Manguinhos
JT  - Historia, ciencias, saude--Manguinhos
JID - 9513999
EDAT- 2012/12/01 00:00
MHDA- 2012/12/01 00:01
CRDT- 2013/02/02 06:00
PHST- 2013/02/02 06:00 [entrez]
PHST- 2012/12/01 00:00 [pubmed]
PHST- 2012/12/01 00:01 [medline]
AID - S0104-59702012000500015 [pii]
AID - 10.1590/s0104-59702012000500015 [doi]
PST - ppublish
SO  - Hist Cienc Saude Manguinhos. 2012 Dec;19 Suppl 1:299-308. doi:
      10.1590/s0104-59702012000500015.


PMID- 23193502
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130704
LR  - 20211021
IS  - 2251-6085 (Print)
IS  - 2251-6085 (Linking)
VI  - 41
IP  - 9
DP  - 2012
TI  - Preoperative informed consent: is it truly informed?
PG  - 25-30
AB  - BACKGROUND: Pre-operative informed consent is an important aspect of surgery, yet
      there has been no formal training regarding it in Pakistan. This study was done
      to assess the preoperative informed consent practice. METHODS: After taking
      informed permission, a questionnaire was filled in during an interview with 350
      patients, who have undergone elective surgical procedures under routine practice 
      conditions from July to October 2010. All the patients were asked a set of
      standard questions which related to the information they were provided before the
      operation as a part of standard informed consent practice. RESULTS: Most i.e. 307
      (87.7%) patients were informed about their condition but very few 12 (3.4%) were 
      briefed regarding complications. Only 17 (4.9%) patients said they knew about the
      risks and complications of proposed anesthesia. One hundred thirty-eight (39.4%) 
      patients said that they were allowed to ask questions while giving consent. Most 
      of the time 196 (56%) consent was taken one day before surgery but in few 2
      (0.6%) instances it was taken on the morning of surgery and on operation table in
      some cases 3 (0.9%) as reported by patients. The consent form was signed by the
      patients themselves in only 204 (58.3%) cases and by their relatives in the rest.
      About half the number of patients 171 (48.9%) interviewed were satisfied from the
      information they received as informed consent process. CONCLUSION: This study
      highlights the poor quality of patient knowledge about surgical procedures and
      the inadequate information provided.
FAU - Jawaid, M
AU  - Jawaid M
AD  - Section of Surgery, Dow University of Health Sciences, Karachi, Pakistan.
FAU - Farhan, M
AU  - Farhan M
FAU - Masood, Z
AU  - Masood Z
FAU - Husnain, Smn
AU  - Husnain S
LA  - eng
PT  - Journal Article
DEP - 20120901
PL  - Iran
TA  - Iran J Public Health
JT  - Iranian journal of public health
JID - 7505531
PMC - PMC3494211
OTO - NOTNLM
OT  - Informed consent
OT  - Operative risks
OT  - Pakistan
OT  - Surgical ethics
EDAT- 2012/11/30 06:00
MHDA- 2012/11/30 06:01
CRDT- 2012/11/30 06:00
PHST- 2012/01/18 00:00 [received]
PHST- 2012/07/27 00:00 [accepted]
PHST- 2012/11/30 06:00 [entrez]
PHST- 2012/11/30 06:00 [pubmed]
PHST- 2012/11/30 06:01 [medline]
PST - ppublish
SO  - Iran J Public Health. 2012;41(9):25-30. Epub 2012 Sep 1.


PMID- 23192778
OWN - NLM
STAT- MEDLINE
DCOM- 20130415
LR  - 20130222
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 266
IP  - 3
DP  - 2013 Mar
TI  - Regional cervical cord atrophy and disability in multiple sclerosis: a
      voxel-based analysis.
PG  - 853-61
LID - 10.1148/radiol.12120813 [doi]
AB  - PURPOSE: To (a) apply an active surface method to map the regional distribution
      of cord atrophy across levels and sectors in a relatively large group of patients
      with multiple sclerosis (MS), (b) compare the anatomic location of cord atrophy
      between patients with relapsing-remitting (RR) MS and those with secondary
      progressive (SP) MS, and (c) assess correlations between atrophy and disability. 
      MATERIALS AND METHODS: This study was approved by the local ethical committee,
      and written informed consent was obtained from each participant.
      High-spatial-resolution magnetic resonance (MR) images of the cervical cord were 
      acquired from 45 patients with RR MS, 26 patients with SP MS, and 67 age-matched 
      healthy control subjects. The active surface method segmented the cord surface
      from C1 to C7 and created output images reformatted in planes perpendicular to
      the estimated cord center line. These unfolded cervical cord images were
      coregistered into a common standard space, and smoothed cord binary masks were
      used as input images for spatial statistics. Voxel-wise between-group comparisons
      and the correlation between regional cord atrophy versus clinical and
      conventional MR imaging variables were assessed with software. RESULTS: Compared 
      with control subjects, patients with RR MS showed localized clusters of atrophy
      in the posterior cord. Conversely, patients with SP MS showed a widespread
      pattern of cord atrophy, predominantly in the posterior and lateral cord columns.
      In patients with MS, cervical cord atrophy was correlated with clinical
      disability, disease duration, and, to a lesser extent, conventional MR imaging
      measures of brain injury. No correlation was found between cord atrophy and the
      presence of focal cord lesions. CONCLUSION: Voxel-wise assessment of the regional
      distribution of damage in the cervical cord is feasible and might improve our
      understanding of the mechanisms related to the development of irreversible
      clinical disability in MS.
FAU - Valsasina, Paola
AU  - Valsasina P
AD  - Neuroimaging Research Unit, Institute of Experimental Neurology, and Department
      of Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele
      University, Via Olgettina 60, Milan 20132, Italy.
FAU - Rocca, Maria A
AU  - Rocca MA
FAU - Horsfield, Mark A
AU  - Horsfield MA
FAU - Absinta, Martina
AU  - Absinta M
FAU - Messina, Roberta
AU  - Messina R
FAU - Caputo, Domenico
AU  - Caputo D
FAU - Comi, Giancarlo
AU  - Comi G
FAU - Filippi, Massimo
AU  - Filippi M
LA  - eng
PT  - Journal Article
DEP - 20121128
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cervical Vertebrae/pathology
MH  - Female
MH  - Humans
MH  - Image Interpretation, Computer-Assisted/*methods
MH  - Imaging, Three-Dimensional/*methods
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/*complications/*pathology
MH  - Muscular Atrophy, Spinal/*etiology/*pathology
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
EDAT- 2012/11/30 06:00
MHDA- 2013/04/16 06:00
CRDT- 2012/11/30 06:00
PHST- 2012/11/30 06:00 [entrez]
PHST- 2012/11/30 06:00 [pubmed]
PHST- 2013/04/16 06:00 [medline]
AID - radiol.12120813 [pii]
AID - 10.1148/radiol.12120813 [doi]
PST - ppublish
SO  - Radiology. 2013 Mar;266(3):853-61. doi: 10.1148/radiol.12120813. Epub 2012 Nov
      28.


PMID- 23190932
OWN - NLM
STAT- MEDLINE
DCOM- 20130826
LR  - 20211021
IS  - 1471-2474 (Electronic)
IS  - 1471-2474 (Linking)
VI  - 13
DP  - 2012 Nov 28
TI  - Functional exercise after total hip replacement (FEATHER): a randomised control
      trial.
PG  - 237
LID - 10.1186/1471-2474-13-237 [doi]
AB  - BACKGROUND: Prolonged physical impairments in range of movement, postural
      stability and walking speed are commonly reported following total hip replacement
      (THR). It is unclear from the current body of evidence what kind of exercises
      should be performed to maximize patient function and quality of life.
      METHODS/DESIGN: This will be a single blind multi centre randomized control trial
      with two arms. Seventy subjects post primary total hip arthroplasty will be
      randomized into either an experimental group (n=35), or to a control group
      (n=35). The experimental group will attend a functional exercise class twice
      weekly for a six week period from week 12 to week 18 post surgery. The functional
      exercise group will follow a circuit based functional exercise class supervised
      by a chartered Physiotherapist. The control group will receive usual care. The
      principal investigator (BM) will perform blinded outcome assessments on all
      patients using validated measures for pain, stiffness, and function using the
      Western Ontario and Mc Master Universities Osteoarthritis index (WOMAC). This is 
      the primary outcome measurement tool. Secondary outcome measurements include
      Quality of life (SF-36), 6 min walk test, Visual Analogue Scale, and the Berg
      Balance score. The WOMAC score will be collated on day five post surgery and
      repeated at week twelve and week eighteen. All other measurements will be taken
      at week 12 and repeated at week eighteen. In addition a blinded radiologist will 
      measure gluteus medius cross sectional area using real time ultrasound for all
      subjects at week 12 and at week 18 to determine if the functional exercise
      programme has any effect on muscle size. DISCUSSION: This randomised controlled
      trial will add to the body of evidence on the relationship between muscle size,
      functional ability, balance, quality of life and time post surgery in patients
      following total hip arthroplasty. The CONSORT guidelines will be followed to
      throughout. Ethical approval has been gained from the Ethics committee Health
      Services Executive Dublin North East.
FAU - Monaghan, Brenda
AU  - Monaghan B
AD  - Department of Physiotherapy, Our Lady's Hospital, Navan, Co Meath, Republic of
      Ireland. Brenda.monaghan@hse.ie
FAU - Grant, Tim
AU  - Grant T
FAU - Hing, Wayne
AU  - Hing W
FAU - Cusack, Tara
AU  - Cusack T
LA  - eng
SI  - ClinicalTrials.gov/NCT01683201
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20121128
PL  - England
TA  - BMC Musculoskelet Disord
JT  - BMC musculoskeletal disorders
JID - 100968565
SB  - IM
MH  - Arthroplasty, Replacement, Hip/psychology/*rehabilitation
MH  - Exercise Therapy/*methods
MH  - Follow-Up Studies
MH  - Humans
MH  - *Quality of Life/psychology
MH  - Recovery of Function/*physiology
MH  - Single-Blind Method
MH  - Treatment Outcome
PMC - PMC3517757
EDAT- 2012/11/30 06:00
MHDA- 2013/08/27 06:00
CRDT- 2012/11/30 06:00
PHST- 2012/09/27 00:00 [received]
PHST- 2012/11/19 00:00 [accepted]
PHST- 2012/11/30 06:00 [entrez]
PHST- 2012/11/30 06:00 [pubmed]
PHST- 2013/08/27 06:00 [medline]
AID - 1471-2474-13-237 [pii]
AID - 10.1186/1471-2474-13-237 [doi]
PST - epublish
SO  - BMC Musculoskelet Disord. 2012 Nov 28;13:237. doi: 10.1186/1471-2474-13-237.


PMID- 23190676
OWN - NLM
STAT- MEDLINE
DCOM- 20130204
LR  - 20121129
IS  - 1538-7488 (Electronic)
IS  - 0002-936X (Linking)
VI  - 112
IP  - 12
DP  - 2012 Dec
TI  - The ethical nursing care of transgender patients: an exploration of bias in
      health care and how it affects this population.
PG  - 61-4
LID - 10.1097/01.NAJ.0000423514.58585.a3 [doi]
FAU - Zunner, Brian P
AU  - Zunner BP
AD  - University of California, San Francisco, School of Nursing, USA.
      brian.zunner@gmail.com
FAU - Grace, Pamela J
AU  - Grace PJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Nurs
JT  - The American journal of nursing
JID - 0372646
SB  - IM
MH  - Adult
MH  - Appendectomy/nursing
MH  - *Attitude of Health Personnel
MH  - Female
MH  - Humans
MH  - Male
MH  - Nurse-Patient Relations/*ethics
MH  - Nursing Care/*ethics
MH  - *Prejudice
MH  - *Transsexualism
MH  - United States
EDAT- 2012/11/30 06:00
MHDA- 2013/02/05 06:00
CRDT- 2012/11/30 06:00
PHST- 2012/11/30 06:00 [entrez]
PHST- 2012/11/30 06:00 [pubmed]
PHST- 2013/02/05 06:00 [medline]
AID - 10.1097/01.NAJ.0000423514.58585.a3 [doi]
AID - 00000446-201212000-00034 [pii]
PST - ppublish
SO  - Am J Nurs. 2012 Dec;112(12):61-4. doi: 10.1097/01.NAJ.0000423514.58585.a3.


PMID- 23190573
OWN - NLM
STAT- MEDLINE
DCOM- 20130528
LR  - 20211203
IS  - 1472-6882 (Electronic)
IS  - 1472-6882 (Linking)
VI  - 12
DP  - 2012 Nov 29
TI  - A comparative study on the hepatoprotective action of bear bile and Coptidis
      Rhizoma aqueous extract on experimental liver fibrosis in rats.
PG  - 239
LID - 10.1186/1472-6882-12-239 [doi]
AB  - AIM OF THE STUDY: Bear bile and Coptidis Rhizoma have been used in Chinese
      medicine with a long tradition in treating heat-diseases. Both bear bile and
      Coptidis Rhizoma are used to treat liver diseases in clinical practice of Chinese
      Medicine. Since bears are currently endangered, it raises the question whether
      the use of bear bile is ethical. To look for substitute for bear bile, the aim of
      this study is to compare the anti-fibrotic effects of Coptidis Rhizoma and its
      major component berberine with the actions of bear bile and its major compound
      tauroursodeoxycholic acid on experimental liver fibrosis in rats. METHOD: Quality
      assessment was conducted with high performance liquid chromatography. The
      experimental liver fibrosis in rats was induced by carbon tetrachloride, alcohol,
      and bile duct ligation respectively. The biochemical criteria in the blood and
      tissue samples were measured to evaluate the anti-fibrotic properties and
      underlying mechanisms of the drugs. RESULTS: Coptidis Rhizoma Aqueous Extract
      (CRAE), berberine, and bear bile exerted anti-fibrotic properties on various
      liver fibrosis models in rats. CRAE and berberine significantly reduced the
      peroxidative stress in liver through increasing the superoxide dismutase enzyme
      activity. CRAE and berberine were able to excrete bilirubin products from the
      liver and protect hepatocytes from cholestatic damage. The effect of CRAE and
      berberine are comparable to that of bear bile. CONCLUSION: Instead of using bear 
      bile, CRAE and berberine can be potential substitutes in treating liver fibrosis.
FAU - Wang, Ning
AU  - Wang N
AD  - School of Chinese Medicine, The University of Hong Kong, Pokfulam, PR China.
FAU - Feng, Yibin
AU  - Feng Y
FAU - Cheung, Fan
AU  - Cheung F
FAU - Chow, Oi-Yee
AU  - Chow OY
FAU - Wang, Xuanbin
AU  - Wang X
FAU - Su, Weiwei
AU  - Su W
FAU - Tong, Yao
AU  - Tong Y
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121129
PL  - England
TA  - BMC Complement Altern Med
JT  - BMC complementary and alternative medicine
JID - 101088661
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Protective Agents)
RN  - CXS4LJR7EL (Coptidis rhizoma extract)
SB  - IM
MH  - Animals
MH  - Bile/*chemistry
MH  - Coptis/*chemistry
MH  - Coptis chinensis
MH  - Disease Models, Animal
MH  - Drugs, Chinese Herbal/*administration & dosage
MH  - Humans
MH  - Liver/drug effects
MH  - Liver Cirrhosis/drug therapy/*prevention & control
MH  - Male
MH  - Mice
MH  - Protective Agents/*administration & dosage
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Ursidae
PMC - PMC3543725
EDAT- 2012/11/30 06:00
MHDA- 2013/05/29 06:00
CRDT- 2012/11/30 06:00
PHST- 2012/06/15 00:00 [received]
PHST- 2012/11/24 00:00 [accepted]
PHST- 2012/11/30 06:00 [entrez]
PHST- 2012/11/30 06:00 [pubmed]
PHST- 2013/05/29 06:00 [medline]
AID - 1472-6882-12-239 [pii]
AID - 10.1186/1472-6882-12-239 [doi]
PST - epublish
SO  - BMC Complement Altern Med. 2012 Nov 29;12:239. doi: 10.1186/1472-6882-12-239.


PMID- 23190503
OWN - NLM
STAT- MEDLINE
DCOM- 20130709
LR  - 20220317
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 13
DP  - 2012 Nov 29
TI  - The Patient Deficit Model Overturned: a qualitative study of patients'
      perceptions of invitation to participate in a randomized controlled trial
      comparing selective bladder preservation against surgery in muscle invasive
      bladder cancer (SPARE, CRUK/07/011).
PG  - 228
LID - 10.1186/1745-6215-13-228 [doi]
AB  - BACKGROUND: Evidence suggests that poor recruitment into clinical trials rests on
      a patient 'deficit' model - an inability to comprehend trial processes. Poor
      communication has also been cited as a possible barrier to recruitment. A
      qualitative patient interview study was included within the feasibility stage of 
      a phase III non-inferiority Randomized Controlled Trial (RCT) (SPARE,
      CRUK/07/011) in muscle invasive bladder cancer. The aim was to illuminate
      problems in the context of randomization. METHODS: The qualitative study used a
      'Framework Analysis' that included 'constant comparison' in which semi-structured
      interviews are transcribed, analyzed, compared and contrasted both between and
      within transcripts. Three researchers coded and interpreted data. RESULTS:
      Twenty-four patients agreed to enter the interview study; 10 decliners of
      randomization and 14 accepters, of whom 2 subsequently declined their allocated
      treatment.The main theme applying to the majority of the sample was confusion and
      ambiguity. There was little indication that confusion directly impacted on
      decisions to enter the SPARE trial. However, confusion did appear to impact on
      ethical considerations surrounding 'informed consent', as well as cause a sense
      of alienation between patients and health personnel.Sub-optimal communication in 
      many guises accounted for the confusion, together with the logistical elements of
      a trial that involved treatment options delivered in a number of geographical
      locations. CONCLUSIONS: These data highlight the difficulty of providing balanced
      and clear trial information within the UK health system, despite best intentions.
      Involvement of multiple professionals can impact on communication processes with 
      patients who are considering participation in RCTs. Our results led us to
      question the 'deficit' model of patient behavior. It is suggested that health
      professionals might consider facilitating a context in which patients feel fully 
      included in the trial enterprise and potentially consider alternatives to
      randomization where complex interventions are being tested. TRIAL REGISTRATION:
      ISRCTN61126465.
FAU - Moynihan, Clare
AU  - Moynihan C
AD  - Institute of Cancer Research, London, UK. Clare.Moynihan@icr.ac.uk
FAU - Lewis, Rebecca
AU  - Lewis R
FAU - Hall, Emma
AU  - Hall E
FAU - Jones, Emma
AU  - Jones E
FAU - Birtle, Alison
AU  - Birtle A
FAU - Huddart, Robert
AU  - Huddart R
CN  - SPARE Trial Management Group
LA  - eng
SI  - ISRCTN/ISRCTN61126465
GR  - C1491/A9895/Cancer Research UK/United Kingdom
GR  - CRUK/07/011/Cancer Research UK/United Kingdom
PT  - Clinical Trial, Phase III
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20121129
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
SB  - IM
MH  - Aged
MH  - Attitude of Health Personnel
MH  - Chemotherapy, Adjuvant
MH  - Communication
MH  - *Comprehension
MH  - Confusion
MH  - Cystectomy/*methods
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Informed Consent
MH  - Interviews as Topic
MH  - Male
MH  - Middle Aged
MH  - *Models, Psychological
MH  - Neoadjuvant Therapy
MH  - Neoplasm Invasiveness
MH  - *Organ Sparing Treatments
MH  - Patient Acceptance of Health Care
MH  - *Patient Selection
MH  - *Perception
MH  - Professional-Patient Relations
MH  - Qualitative Research
MH  - Radiotherapy, Adjuvant
MH  - Research Subjects/*psychology
MH  - Therapeutic Equipoise
MH  - United Kingdom
MH  - Urinary Bladder/pathology/*surgery
MH  - Urinary Bladder Neoplasms/pathology/*surgery
PMC - PMC3554516
EDAT- 2012/11/30 06:00
MHDA- 2013/07/10 06:00
CRDT- 2012/11/30 06:00
PHST- 2012/05/14 00:00 [received]
PHST- 2012/11/02 00:00 [accepted]
PHST- 2012/11/30 06:00 [entrez]
PHST- 2012/11/30 06:00 [pubmed]
PHST- 2013/07/10 06:00 [medline]
AID - 1745-6215-13-228 [pii]
AID - 10.1186/1745-6215-13-228 [doi]
PST - epublish
SO  - Trials. 2012 Nov 29;13:228. doi: 10.1186/1745-6215-13-228.


PMID- 23190344
OWN - NLM
STAT- MEDLINE
DCOM- 20130903
LR  - 20130315
IS  - 1365-277X (Electronic)
IS  - 0952-3871 (Linking)
VI  - 26
IP  - 2
DP  - 2013 Apr
TI  - The bioethical experiences of student dietitians on their final clinical
      placement.
PG  - 198-203
LID - 10.1111/jhn.12007 [doi]
AB  - BACKGROUND: Dietetic students are exposed to bioethical dilemmas on clinical
      placements; however, the nature of these situations has not been investigated.
      The present study aimed to analyse students' reports of incidents and their
      associated personal development plans (PDP) to assess the type of ethical
      incidents faced and how they cope with them. METHODS: Final-year dietetic
      students were recruited via an announcement in class. The students' PDPs were
      analysed using thematic analysis to identify the type of ethical issues faced and
      how they felt about them. The 500-word PDPs were submitted after the final
      placement. RESULTS: Thirteen (13/26) students identified 'ethics' as a learning
      need and most of these incidents were related to enteral feeding (10/13). Ethical
      issues identified related to nonmaleficence; best interest; consent and capacity;
      truth telling and integrity; autonomy and substituted decision-making; futile
      treatment; beneficence and confidentially. The themes for how the students coped 
      included being unsure; lack of confidence or knowledge with ethics and/or with
      communication; lack of experience; unease/concern about shared decision-making;
      and their own role in the situation. CONCLUSIONS: Student dietitians are exposed 
      to a wide range of complex ethical clinical situations, with those related to
      enteral feeding being the most common. Students felt unsure of what to do and
      lacked confidence, which resulted in unease and concern; however, students
      appeared to have some ethical sensitivity. Communication problems with the
      multidisciplinary team or families were a common theme. Clinical educators need
      to support students in these situations and act as role models.
CI  - (c) 2012 The Authors Journal of Human Nutrition and Dietetics (c) 2012 The
      British Dietetic Association Ltd.
FAU - Tighe, B
AU  - Tighe B
AD  - Department of Physiotherapy and Dietetics, Coventry University, Coventry, UK.
      b.tighe@coventry.ac.uk
FAU - Mainwaring, J
AU  - Mainwaring J
LA  - eng
PT  - Journal Article
DEP - 20121129
PL  - England
TA  - J Hum Nutr Diet
JT  - Journal of human nutrition and dietetics : the official journal of the British
      Dietetic Association
JID - 8904840
SB  - IM
MH  - Adult
MH  - Attitude of Health Personnel
MH  - *Bioethical Issues
MH  - Communication Barriers
MH  - Community Health Services
MH  - Diet Therapy/*ethics
MH  - Dietetics/*education/ethics
MH  - England
MH  - Enteral Nutrition/ethics
MH  - Hospitals, Public
MH  - Humans
MH  - Needs Assessment
MH  - Nutritional Support/*ethics
MH  - Self Report
MH  - State Medicine
MH  - Young Adult
EDAT- 2012/11/30 06:00
MHDA- 2013/09/04 06:00
CRDT- 2012/11/30 06:00
PHST- 2012/11/30 06:00 [entrez]
PHST- 2012/11/30 06:00 [pubmed]
PHST- 2013/09/04 06:00 [medline]
AID - 10.1111/jhn.12007 [doi]
PST - ppublish
SO  - J Hum Nutr Diet. 2013 Apr;26(2):198-203. doi: 10.1111/jhn.12007. Epub 2012 Nov
      29.


PMID- 23189906
OWN - NLM
STAT- MEDLINE
DCOM- 20130108
LR  - 20121129
IS  - 1029-4864 (Print)
IS  - 1029-4864 (Linking)
VI  - 67
IP  - 1
DP  - 2012 Feb
TI  - Dental ethics case 18: Use of amalgam for dental restorations.
PG  - 36-8
FAU - Naidoo, S
AU  - Naidoo S
AD  - Faculty of Dentistry, University of the Western Cape, Department of Community
      Dentistry, Private Bag X1, Tygerberg 7505. suenaidoo@uwc.ac.za
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - SADJ
JT  - SADJ : journal of the South African Dental Association = tydskrif van die
      Suid-Afrikaanse Tandheelkundige Vereniging
JID - 9812497
RN  - 8049-85-2 (Dental Amalgam)
MH  - Decision Making/ethics
MH  - *Dental Amalgam
MH  - Dental Care/ethics
MH  - Dental Restoration, Permanent/*ethics
MH  - Dentists/*ethics
MH  - *Ethics, Dental
MH  - Humans
MH  - Patient Participation
MH  - Retreatment
MH  - Risk Assessment
MH  - Safety
EDAT- 2012/11/30 06:00
MHDA- 2013/01/09 06:00
CRDT- 2012/11/30 06:00
PHST- 2012/11/30 06:00 [entrez]
PHST- 2012/11/30 06:00 [pubmed]
PHST- 2013/01/09 06:00 [medline]
PST - ppublish
SO  - SADJ. 2012 Feb;67(1):36-8.


PMID- 23189897
OWN - NLM
STAT- MEDLINE
DCOM- 20121211
LR  - 20121129
IS  - 1029-4864 (Print)
IS  - 1029-4864 (Linking)
VI  - 67
IP  - 2
DP  - 2012 Mar
TI  - Dental ethics case 19: What are my ethical responsibilities when I suspect a
      colleague of substance abuse?
PG  - 82, 84
AB  - The situation described in this case scenario is an unwelcome one and can often
      lead to a breakdown in the relationship between professional colleagues. Many of 
      these must be handled by scrupulous adherence to basic ethical principles. Where 
      such conflicts do arise, every effort should be made to contain them in a manner 
      which: avoids placing patients at risk; maintains the continuity of patient care 
      and safeguards their rights and the quality of the dental care they receive;
      avoids bringing the profession into disrepute; maintains public confidence in the
      profession; treats professional colleagues as we would wish to be treated
      ourselves.
FAU - Naidoo, S
AU  - Naidoo S
AD  - Faculty of Dentistry, University of the Western Cape, Department of Community
      Dentistry, Private Bag X1, Tygerberg 7505. suenaidoo@uwc.ac.za
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - SADJ
JT  - SADJ : journal of the South African Dental Association = tydskrif van die
      Suid-Afrikaanse Tandheelkundige Vereniging
JID - 9812497
MH  - *Ethics, Dental
MH  - Humans
MH  - Interprofessional Relations/ethics
MH  - Partnership Practice, Dental/*ethics
MH  - Professional Impairment/*legislation & jurisprudence
MH  - *Social Responsibility
MH  - South Africa
MH  - Substance-Related Disorders/*psychology
EDAT- 2012/11/30 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/11/30 06:00
PHST- 2012/11/30 06:00 [entrez]
PHST- 2012/11/30 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
PST - ppublish
SO  - SADJ. 2012 Mar;67(2):82, 84.


PMID- 23189804
OWN - NLM
STAT- MEDLINE
DCOM- 20121211
LR  - 20121129
IS  - 0002-7979 (Print)
IS  - 0002-7979 (Linking)
VI  - 79
IP  - 3
DP  - 2012 Fall
TI  - A systematic format for resolving ethical issues in clinical periodontics.
PG  - 42-7
AB  - Ethical dilemmas are becoming increasingly common in dentistry and periodontics. 
      Clinicians, challenged with such dilemmas, may not know how to apply the
      appropriate moral reasoning needed to resolve these situations especially when
      any of the five fundamental principles of ethics that form the foundation of the 
      American Dental Association Principles of Ethics and Code of Professional
      Conduct--patient autonomy, nonmaleficence, beneficence, justice, and
      veracity--come into conflict with each other. The author describes one clinical
      case that presented with an ethical dilemma. An analytic framework, used in
      medicine, is introduced and used to solve the clinical case on whether to proceed
      with periodontal surgery on a patient who is not aware of his terminal prognosis 
      from metastatic prostate cancer. Upon using the analytic framework,
      recommendations are made on the ethically appropriate path for the periodontist
      to follow in providing care for the patient's periodontal problem consistent with
      the principles of patient autonomy, respect for persons, and veracity.
FAU - Schloss, Alexander J
AU  - Schloss AJ
AD  - New York University College of Dentistry, USA. ajs9@nyu.edu
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Am Coll Dent
JT  - The Journal of the American College of Dentists
JID - 7503057
SB  - IM
MH  - Adenocarcinoma/drug therapy/secondary
MH  - American Dental Association
MH  - Chronic Periodontitis/surgery
MH  - Codes of Ethics
MH  - Ethical Analysis/*methods
MH  - *Ethics, Dental
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Interprofessional Relations/ethics
MH  - Male
MH  - Middle Aged
MH  - Periodontics/*ethics
MH  - Prostatic Neoplasms/drug therapy
MH  - *Terminally Ill
MH  - United States
EDAT- 2012/11/30 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/11/30 06:00
PHST- 2012/11/30 06:00 [entrez]
PHST- 2012/11/30 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
PST - ppublish
SO  - J Am Coll Dent. 2012 Fall;79(3):42-7.


PMID- 23189609
OWN - NLM
STAT- MEDLINE
DCOM- 20121211
LR  - 20220316
IS  - 0306-3127 (Print)
IS  - 0306-3127 (Linking)
VI  - 42
IP  - 5
DP  - 2012 Oct
TI  - Trust and regulatory organisations: the role of local knowledge and facework in
      research ethics review.
PG  - 662-83
AB  - While trust is seen as central to most social relations, most writers, including 
      sociologists of science, assume that modern trust relations--especially those in 
      regulatory relationships - tend towards the impersonal. Drawing on ethnographic
      material from one kind of scientific oversight body--research ethics committees
      based in the UK NHS--this paper argues that interpersonal trust is crucial to
      regulatory decision-making and intimately bound up with the way in which these
      oversight bodies work, and that as such they build on, rather than challenge, the
      trust-based nature of the scientific community.
FAU - Hedgecoe, Adam M
AU  - Hedgecoe AM
AD  - Cesagen, Cardiff School of Social Sciences, Cardiff University, Cardiff, UK.
      hedgecoeam@cardiff.ac.uk
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Soc Stud Sci
JT  - Social studies of science
JID - 7506743
MH  - Anthropology, Cultural
MH  - *Decision Making
MH  - *Ethics Committees, Research
MH  - Ethics, Professional
MH  - Ethics, Research
MH  - *Interpersonal Relations
MH  - National Health Programs
MH  - Research Design
MH  - *Trust
MH  - United Kingdom
EDAT- 2012/11/30 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/11/30 06:00
PHST- 2012/11/30 06:00 [entrez]
PHST- 2012/11/30 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - 10.1177/0306312712446364 [doi]
PST - ppublish
SO  - Soc Stud Sci. 2012 Oct;42(5):662-83. doi: 10.1177/0306312712446364.


PMID- 23189167
OWN - NLM
STAT- MEDLINE
DCOM- 20130516
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 11
DP  - 2012
TI  - Guidelines for guidelines: are they up to the task? A comparative assessment of
      clinical practice guideline development handbooks.
PG  - e49864
LID - 10.1371/journal.pone.0049864 [doi]
AB  - OBJECTIVES: We conducted a comparative review of clinical practice guideline
      development handbooks. We aimed to identify the main guideline development tasks,
      assign weights to the importance of each task using expert opinions and identify 
      the handbooks that provided a comprehensive coverage of the tasks. METHODS: We
      systematically searched and included handbooks published (in English language) by
      national, international or professional bodies responsible for evidenced-based
      guideline development. We reviewed the handbooks to identify the main guideline
      development tasks and scored each handbook for each task from 0 (the handbook did
      not mention the task) to 2 (the task suitably addressed and explained), and
      calculated a weighted score for each handbook. The tasks included in over 75% of 
      the handbooks were considered as 'necessary' tasks. RESULT: Nineteen guideline
      development handbooks and twenty seven main tasks were identified. The guideline 
      handbooks' weighted scores ranged from 100 to 220. Four handbooks scored over 80%
      of the maximum possible score, developed by the National Institute for Health and
      Clinical Excellence, Swiss Centre for International Health, Scottish
      Intercollegiate Guidelines Network and World Health Organization. Necessary tasks
      were: selecting the guideline topic, determining the guideline scope, identifying
      relevant existing guidelines, involving the consumers, forming guideline
      development group,, developing clinical questions, systematic search for
      evidence, selecting relevant evidence, appraising identifies research evidence,
      making group decision, grading available evidence, creating recommendations,
      final stakeholder consultation, guideline implementation strategies, updating
      recommendations and correcting potential errors. DISCUSSION: Adequate details for
      evidence based development of guidelines were still lacking from many handbooks. 
      The tasks relevant to ethical issues and piloting were missing in most handbooks.
      The findings help decision makers in identifying the necessary tasks for
      guideline development, provide an updated comparative list of guideline
      development handbooks, and provide a checklist to assess the comprehensiveness of
      guideline development processes.
FAU - Ansari, Shabnam
AU  - Ansari S
AD  - Students' Scientific Research Center, School of Medicine, Tehran University of
      Medical Sciences, Tehran, Iran.
FAU - Rashidian, Arash
AU  - Rashidian A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121126
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Humans
MH  - Practice Guidelines as Topic/*standards
PMC - PMC3506587
EDAT- 2012/11/29 06:00
MHDA- 2013/05/17 06:00
CRDT- 2012/11/29 06:00
PHST- 2012/02/15 00:00 [received]
PHST- 2012/10/17 00:00 [accepted]
PHST- 2012/11/29 06:00 [entrez]
PHST- 2012/11/29 06:00 [pubmed]
PHST- 2013/05/17 06:00 [medline]
AID - 10.1371/journal.pone.0049864 [doi]
AID - PONE-D-12-05395 [pii]
PST - ppublish
SO  - PLoS One. 2012;7(11):e49864. doi: 10.1371/journal.pone.0049864. Epub 2012 Nov 26.


PMID- 23189064
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121129
LR  - 20211021
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 3
DP  - 2012
TI  - Obtaining the optimal dose in alcohol dependence studies.
PG  - 100
LID - 10.3389/fpsyt.2012.00100 [doi]
AB  - In alcohol dependence studies, the treatment effect at different dose levels
      remains to be ascertained. Establishing this effect would aid us in identifying
      the best dose that has satisfactory efficacy while minimizing the rate of adverse
      events. We advocate the use of dose-finding methodology that has been
      successfully implemented in the cancer and HIV settings to identify the optimal
      dose in a cost-effective way. Specifically, we describe the continual
      reassessment method (CRM), an adaptive design proposed for cancer trials to
      reconcile the needs of dose-finding experiments with the ethical demands of
      established medical practice. We are applying adaptive designs for identifying
      the optimal dose of medications for the first time in the context of
      pharmacotherapy research in alcoholism. We provide an example of a topiramate
      trial as an illustration of how adaptive designs can be used to locate the
      optimal dose in alcohol treatment trials. It is believed that the introduction of
      adaptive design methods will enable the development of medications for the
      treatment of alcohol dependence to be accelerated.
FAU - Wages, Nolan A
AU  - Wages NA
AD  - Division of Translational Research and Applied Statistics, Department of Public
      Health Sciences, University of Virginia Charlottesville, VA, USA.
FAU - Liu, Lei
AU  - Liu L
FAU - O'Quigley, John
AU  - O'Quigley J
FAU - Johnson, Bankole A
AU  - Johnson BA
LA  - eng
GR  - RC1 AA019274/AA/NIAAA NIH HHS/United States
PT  - Journal Article
DEP - 20121122
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC3504325
OTO - NOTNLM
OT  - alcohol research
OT  - continual reassessment method
OT  - dose-finding
OT  - maximum tolerated dose
OT  - most successful dose
EDAT- 2012/11/29 06:00
MHDA- 2012/11/29 06:01
CRDT- 2012/11/29 06:00
PHST- 2012/07/06 00:00 [received]
PHST- 2012/11/01 00:00 [accepted]
PHST- 2012/11/29 06:00 [entrez]
PHST- 2012/11/29 06:00 [pubmed]
PHST- 2012/11/29 06:01 [medline]
AID - 10.3389/fpsyt.2012.00100 [doi]
PST - epublish
SO  - Front Psychiatry. 2012 Nov 22;3:100. doi: 10.3389/fpsyt.2012.00100. eCollection
      2012.


PMID- 23188961
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121129
LR  - 20220408
IS  - 1998-359X (Electronic)
IS  - 0972-5229 (Linking)
VI  - 16
IP  - 3
DP  - 2012 Jul
TI  - Guidelines for end-of-life and palliative care in Indian intensive care units'
      ISCCM consensus Ethical Position Statement.
PG  - 166-81
LID - 10.4103/0972-5229.102112 [doi]
FAU - Mani, R K
AU  - Mani RK
AD  - Committee for the Development of Guidelines for limiting life-prolonging
      interventions and providing palliative care towards the end-of-life: Indian
      Society of Critical Care Medicine.
FAU - Amin, P
AU  - Amin P
FAU - Chawla, R
AU  - Chawla R
FAU - Divatia, J V
AU  - Divatia JV
FAU - Kapadia, F
AU  - Kapadia F
FAU - Khilnani, P
AU  - Khilnani P
FAU - Myatra, S N
AU  - Myatra SN
FAU - Prayag, S
AU  - Prayag S
FAU - Rajagopalan, R
AU  - Rajagopalan R
FAU - Todi, S K
AU  - Todi SK
FAU - Uttam, R
AU  - Uttam R
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Crit Care Med
JT  - Indian journal of critical care medicine : peer-reviewed, official publication of
      Indian Society of Critical Care Medicine
JID - 101208863
PMC - PMC3506078
EDAT- 2012/11/29 06:00
MHDA- 2012/11/29 06:01
CRDT- 2012/11/29 06:00
PHST- 2012/11/29 06:00 [entrez]
PHST- 2012/11/29 06:00 [pubmed]
PHST- 2012/11/29 06:01 [medline]
AID - 10.4103/0972-5229.102112 [doi]
AID - IJCCM-16-166 [pii]
PST - ppublish
SO  - Indian J Crit Care Med. 2012 Jul;16(3):166-81. doi: 10.4103/0972-5229.102112.


PMID- 23188883
OWN - NLM
STAT- MEDLINE
DCOM- 20140106
LR  - 20191210
IS  - 1461-7005 (Electronic)
IS  - 1362-3613 (Linking)
VI  - 17
IP  - 3
DP  - 2013 May
TI  - 'Sometimes I want to play by myself': Understanding what friendship means to
      children with autism in mainstream primary schools.
PG  - 296-316
LID - 10.1177/1362361312467866 [doi]
AB  - Research has shown that friendship impacts the overall experience of mainstream
      school for autistic children. Using a unique combination of quantitative,
      qualitative and social network methods, we investigated the extent and nature of 
      autistic children's friendships from their perspective and from those of their
      mothers, teachers and classroom peers. Consistent with previous research,
      children with autism (n = 12), aged between 9 and 11 years, rated their
      friendships to be of poorer quality than their non-autistic classroom peers (n = 
      11). There was, however, much variability in autistic children's ratings, which, 
      unexpectedly, was related to neither children's cognitive ability nor their
      theory of mind ability. Encouragingly, the children generally reported
      satisfaction with their friendships, and although no child was socially isolated,
      the degree of inclusion in friendship networks varied widely. Furthermore,
      autistic children's social motivation emerged as a key factor in parents' and
      teachers' reports in determining both the nature and extent of their friendships.
      Adults played an active role in supporting children's friendships, but this
      sometimes conflicted with what the children wanted. These findings highlight the 
      need to ascertain the perspectives of young people with autism on their
      friendships and to consider the social and ethical implications of when and how
      to intervene.
FAU - Calder, Lynsey
AU  - Calder L
AD  - Institute of Education, University of London, UK.
FAU - Hill, Vivian
AU  - Hill V
FAU - Pellicano, Elizabeth
AU  - Pellicano E
LA  - eng
PT  - Journal Article
DEP - 20121127
PL  - England
TA  - Autism
JT  - Autism : the international journal of research and practice
JID - 9713494
SB  - IM
MH  - Autistic Disorder/*psychology
MH  - Child
MH  - Female
MH  - Friends/*psychology
MH  - Humans
MH  - *Interpersonal Relations
MH  - Mainstreaming, Education
MH  - Male
MH  - Peer Group
MH  - Schools
MH  - Social Adjustment
MH  - *Social Behavior
MH  - Social Perception
MH  - Surveys and Questionnaires
MH  - Theory of Mind
OTO - NOTNLM
OT  - friendships
OT  - mainstream school
OT  - peer relationships
OT  - social skills
OT  - theory of mind
EDAT- 2012/11/29 06:00
MHDA- 2014/01/07 06:00
CRDT- 2012/11/29 06:00
PHST- 2012/11/29 06:00 [entrez]
PHST- 2012/11/29 06:00 [pubmed]
PHST- 2014/01/07 06:00 [medline]
AID - 1362361312467866 [pii]
AID - 10.1177/1362361312467866 [doi]
PST - ppublish
SO  - Autism. 2013 May;17(3):296-316. doi: 10.1177/1362361312467866. Epub 2012 Nov 27.


PMID- 23188692
OWN - NLM
STAT- MEDLINE
DCOM- 20131217
LR  - 20130508
IS  - 1099-0798 (Electronic)
IS  - 0735-3936 (Linking)
VI  - 31
IP  - 2
DP  - 2013 Mar-Apr
TI  - Empathy in forensic evaluations: a systematic reconsideration.
PG  - 192-202
LID - 10.1002/bsl.2042 [doi]
AB  - This paper reexamines the Shuman seminal paper arguing against empathic behaviors
      in forensic evaluations. Shuman concluded that empathy by examiners seduces
      evaluees into believing a therapeutic relationship exists. We reconsider empathy 
      as an element of rapport and a helpful supplement in a successful assessment.
      Actively avoiding empathy could lead to cold and callous examiner
      self-presentation, which may in turn produce biased and negative results. In this
      paper we assert that ethical forensic professionals may use moderate empathy
      during an assessment. Examiners should consider it not as a component of
      subjectivity and pseudotherapy, but rather as a potentially useful tool for
      effective assessments.
CI  - Copyright (c) 2012 John Wiley & Sons, Ltd.
FAU - Brodsky, Stanley L
AU  - Brodsky SL
AD  - Department of Psychology, The University of Alabama, Box 870348, Tuscaloosa, AL
      35487-0348, USA. sbrodsky@bama.ua.edu
FAU - Wilson, Jennifer Kelly
AU  - Wilson JK
LA  - eng
PT  - Journal Article
DEP - 20121127
PL  - United States
TA  - Behav Sci Law
JT  - Behavioral sciences & the law
JID - 8404861
SB  - IM
MH  - *Empathy
MH  - *Forensic Psychiatry
MH  - Humans
MH  - *Interpersonal Relations
EDAT- 2012/11/29 06:00
MHDA- 2013/12/18 06:00
CRDT- 2012/11/29 06:00
PHST- 2012/11/29 06:00 [entrez]
PHST- 2012/11/29 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
AID - 10.1002/bsl.2042 [doi]
PST - ppublish
SO  - Behav Sci Law. 2013 Mar-Apr;31(2):192-202. doi: 10.1002/bsl.2042. Epub 2012 Nov
      27.


PMID- 23188595
OWN - NLM
STAT- MEDLINE
DCOM- 20131028
LR  - 20130425
IS  - 2041-1626 (Electronic)
IS  - 2041-1618 (Linking)
VI  - 4
IP  - 2
DP  - 2013 May
TI  - RUNX2 gene status in a cleidocranial dysplasia patient without supernumerary
      teeth.
PG  - 124-7
LID - 10.1111/jicd.12019 [doi]
AB  - OBJECTIVE: This study sought to perform mutational analysis of the RUNX2 gene in 
      an 8-year-old girl with a diagnosis of cleidocranial dysplasia (CCD) without
      supernumerary teeth (proband) and her parents, plus in age and gender matched
      control subjects. METHODS: Ethical approval and informed consent was obtained for
      this study. Blood samples were obtained and the isolated DNA was used to amplify 
      exons 0-7 of the RUNX2 gene using specific primers, which was subsequently
      sequenced. RESULTS: No mutations were identified in the coding regions of the
      RUNX2 gene. CONCLUSION: The absence of supernumerary teeth in this individual
      with CCD demonstrates that there are variations in the phenotypes and mere
      absence of mutations does not imply that CCD phenotype is not governed by RUNX2
      gene as only two-thirds of the individuals exhibiting a CCD phenotype would
      reveal a RUNX2 mutation; therefore, the influence of copy number variations
      including large insertions, intragenic deletions, duplications, and inversions of
      genes cannot be excluded completely.
CI  - (c) 2012 Wiley Publishing Asia Pty Ltd.
FAU - Anthonappa, Robert P
AU  - Anthonappa RP
AD  - Paediatric Dentistry, School of Dentistry, The University of Western Australia,
      Perth, Australia. robert_prashanth@yahoo.com
FAU - King, Nigel M
AU  - King NM
FAU - Mahmoud Rabie, Abou-Bakr
AU  - Mahmoud Rabie AB
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121127
PL  - Australia
TA  - J Investig Clin Dent
JT  - Journal of investigative and clinical dentistry
JID - 101524471
RN  - 0 (Core Binding Factor Alpha 1 Subunit)
SB  - IM
MH  - Child
MH  - Cleidocranial Dysplasia/*genetics
MH  - Core Binding Factor Alpha 1 Subunit/*genetics
MH  - Female
MH  - Humans
MH  - Pedigree
MH  - *Tooth, Supernumerary/genetics
EDAT- 2012/11/29 06:00
MHDA- 2013/10/29 06:00
CRDT- 2012/11/29 06:00
PHST- 2012/07/07 00:00 [received]
PHST- 2012/09/23 00:00 [revised]
PHST- 2012/09/30 00:00 [accepted]
PHST- 2012/11/29 06:00 [entrez]
PHST- 2012/11/29 06:00 [pubmed]
PHST- 2013/10/29 06:00 [medline]
AID - 10.1111/jicd.12019 [doi]
PST - ppublish
SO  - J Investig Clin Dent. 2013 May;4(2):124-7. doi: 10.1111/jicd.12019. Epub 2012 Nov
      27.


PMID- 23188589
OWN - NLM
STAT- MEDLINE
DCOM- 20140203
LR  - 20161125
IS  - 1522-2586 (Electronic)
IS  - 1053-1807 (Linking)
VI  - 38
IP  - 1
DP  - 2013 Jul
TI  - Assessment of perfusion in normal carpal bones with dynamic gadolinium-enhanced
      MRI at 3 Tesla.
PG  - 168-72
LID - 10.1002/jmri.23951 [doi]
AB  - PURPOSE: To investigate the normal enhancement patterns of the scaphoid, lunate, 
      and capitate bones with dynamic contrast-enhanced magnetic resonance imaging
      (MRI). MATERIALS AND METHODS: The study was approved by the hospital's Ethics
      Committee. Nineteen volunteers (13 female, 6 male; mean age 38 years) were
      examined and all gave written consent. Perfusion was assessed at 3 Tesla using
      dynamic contrast-enhanced MRI. After two-dimensional (2D) motion correction of
      the data set, regions of interest were placed in the capitate, lunate, and distal
      and proximal pole of scaphoid bone and from the mean signal intensities (SI), the
      enhancement was computed. The four locations were compared for time to peak,
      delay time, maximum enhancement, and maximum slope using Friedman's two-way
      analysis of variance. RESULTS: Typical SI versus time curves revealed two
      components: a faster component with strong contrast enhancement and a slow
      component with prolonged enhancement. The mean value (standard deviation, SD) for
      maximum enhancement was 51 (33)% in the capitate, 54 (25)% in the lunate, 51
      (34)% in the proximal pole and 51 (28)% in the distal pole of the scaphoid. The
      result of the Friedman test showed no significant difference (P < 0.05) in the
      perfusion variables between the capitate, lunate, and distal and proximal
      scaphoid bones. CONCLUSION: Assessment of perfusion in normal carpal bone using
      contrast-enhanced MRI is possible. Optimization of the method and understanding
      of the normal perfusion may allow evaluation of pathological conditions such as
      osteonecrosis.
CI  - Copyright (c) 2013 Wiley Periodicals, Inc.
FAU - Muller, Gunilla M
AU  - Muller GM
AD  - Department of Radiology, Lund University, Malmo, Sweden. gunilla.muller@med.lu.se
FAU - Mansson, Sven
AU  - Mansson S
FAU - Muller, Markus F
AU  - Muller MF
FAU - Ekberg, Olle
AU  - Ekberg O
FAU - Bjorkman, Anders
AU  - Bjorkman A
LA  - eng
PT  - Journal Article
DEP - 20121127
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 6HG8UB2MUY (Meglumine)
RN  - L0ND3981AG (gadoterate meglumine)
SB  - IM
MH  - Adult
MH  - Blood Flow Velocity/physiology
MH  - Carpal Bones/*blood supply/*physiology
MH  - Contrast Media
MH  - Female
MH  - Healthy Volunteers
MH  - Humans
MH  - Magnetic Resonance Angiography/*methods
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - *Meglumine
MH  - Middle Aged
MH  - *Organometallic Compounds
MH  - Reference Values
MH  - Regional Blood Flow/*physiology
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
OTO - NOTNLM
OT  - carpal bones
OT  - contrast-enhancement
OT  - magnetic resonance imaging
OT  - perfusion
EDAT- 2012/11/29 06:00
MHDA- 2014/02/04 06:00
CRDT- 2012/11/29 06:00
PHST- 2012/05/15 00:00 [received]
PHST- 2012/10/15 00:00 [accepted]
PHST- 2012/11/29 06:00 [entrez]
PHST- 2012/11/29 06:00 [pubmed]
PHST- 2014/02/04 06:00 [medline]
AID - 10.1002/jmri.23951 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2013 Jul;38(1):168-72. doi: 10.1002/jmri.23951. Epub 2012
      Nov 27.


PMID- 23188406
OWN - NLM
STAT- MEDLINE
DCOM- 20140305
LR  - 20211021
IS  - 1176-7529 (Print)
IS  - 1176-7529 (Linking)
VI  - 9
IP  - 4
DP  - 2012 Dec
TI  - Professional ethics in context: practising rural Canadian psychologists.
PG  - 463-77
LID - 10.1007/s11673-012-9394-7 [doi]
AB  - The complexities of professional ethics are best understood and interpreted
      within their sociohistorical context. This paper focuses on the experience of 20 
      rural psychologists from across Canada, a context rife with demographic and
      practice characteristics that may instigate ethical issues. Employing hermeneutic
      phenomenology, these qualitative research results are indicative of professional 
      struggles that impacted the participants' experience of professional ethics and
      raised key questions about policy and practise. Concerns regarding competition
      highlight potential professional vulnerability, beget the idea of fostering
      general psychological practice, and question the role of professional bodies in
      addressing rural shortages. Dependency on government funding models and decisions
      highlights the benefits and medical cost-offset effect of psychological services'
      role in funded medical care. The controversial prescriptive authority debate for 
      psychologists raises myriad concerns that are particularly salient to rural
      practitioners. These include changes to training and practice, with risks of
      psychopharmacology gaining prominence over behavioural health interventions.
      National inconsistencies in level of registration add to the growing shortage of 
      practitioners. Finally, the results illuminate the need for advocacy to move
      beyond the literature and into public policy to increase public awareness,
      decrease the stigma of mental illness, and develop rural Canadian psychology.
      Although limited to this study, these results allowed for a fuller and more
      robust understanding of rural practice in consideration of professional ethics,
      which may inform policy, science, or ethical clinical practice.
FAU - Malone, Judi L
AU  - Malone JL
AD  - Athabasca University, Athabasca, Alberta, Canada. judim@athabascau.ca
LA  - eng
PT  - Journal Article
DEP - 20121012
PL  - Netherlands
TA  - J Bioeth Inq
JT  - Journal of bioethical inquiry
JID - 101250741
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Canada
MH  - Female
MH  - Health Policy
MH  - Humans
MH  - Male
MH  - Narration
MH  - Private Practice/*ethics
MH  - Psychology, Clinical/*ethics
MH  - Qualitative Research
MH  - Rural Health Services/*ethics
EDAT- 2012/11/29 06:00
MHDA- 2014/03/07 06:00
CRDT- 2012/11/29 06:00
PHST- 2011/08/26 00:00 [received]
PHST- 2012/08/27 00:00 [accepted]
PHST- 2012/11/29 06:00 [entrez]
PHST- 2012/11/29 06:00 [pubmed]
PHST- 2014/03/07 06:00 [medline]
AID - 10.1007/s11673-012-9394-7 [doi]
PST - ppublish
SO  - J Bioeth Inq. 2012 Dec;9(4):463-77. doi: 10.1007/s11673-012-9394-7. Epub 2012 Oct
      12.


PMID- 23188405
OWN - NLM
STAT- MEDLINE
DCOM- 20140305
LR  - 20211021
IS  - 1176-7529 (Print)
IS  - 1176-7529 (Linking)
VI  - 9
IP  - 4
DP  - 2012 Dec
TI  - Addressing ethical considerations and authors' conflict of interest disclosure in
      medical journals in Iran.
PG  - 457-62
LID - 10.1007/s11673-012-9393-8 [doi]
AB  - The purpose of this study was to examine how ethical approval and competing
      interests are addressed by medical journals in Iran. In a cross-sectional study, 
      151 journals accredited by the Publications Commission of the Ministry of Health 
      and Medical Education were reviewed. Data collection was carried out by assessing
      journal guidelines and conducting structured phone interviews with journal
      managers, focusing on how ethical considerations and conflicts of interest (COI) 
      are addressed. Overall, 135 of the 151 journals (89.4 percent) examined some
      aspect of ethical considerations of submitted articles. Authors were required to 
      disclose their financial sponsors by 98 journals (64.9 percent), while COI
      disclosure was required by 67 journals (44.4 percent). We conclude that the rate 
      of addressing ethical considerations is not far from ideal, but the requirement
      for COI disclosure needs more attention.
FAU - Heidari, Akram
AU  - Heidari A
AD  - Ethics, Religion and Medicine Research Center, Qom University of Medical
      Sciences, Qom, Iran.
FAU - Adeli, Seyyed Hassan
AU  - Adeli SH
FAU - Mehravaran, Shiva
AU  - Mehravaran S
FAU - Asghari, Fariba
AU  - Asghari F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121025
PL  - Netherlands
TA  - J Bioeth Inq
JT  - Journal of bioethical inquiry
JID - 101250741
SB  - IM
MH  - *Bibliometrics
MH  - *Conflict of Interest
MH  - Cross-Sectional Studies
MH  - Disclosure/*ethics
MH  - *Editorial Policies
MH  - Humans
MH  - Iran
MH  - Periodicals as Topic/*ethics
EDAT- 2012/11/29 06:00
MHDA- 2014/03/07 06:00
CRDT- 2012/11/29 06:00
PHST- 2011/10/26 00:00 [received]
PHST- 2012/08/27 00:00 [accepted]
PHST- 2012/11/29 06:00 [entrez]
PHST- 2012/11/29 06:00 [pubmed]
PHST- 2014/03/07 06:00 [medline]
AID - 10.1007/s11673-012-9393-8 [doi]
PST - ppublish
SO  - J Bioeth Inq. 2012 Dec;9(4):457-62. doi: 10.1007/s11673-012-9393-8. Epub 2012 Oct
      25.


PMID- 23188403
OWN - NLM
STAT- MEDLINE
DCOM- 20140305
LR  - 20211021
IS  - 1176-7529 (Print)
IS  - 1176-7529 (Linking)
VI  - 9
IP  - 4
DP  - 2012 Dec
TI  - The importance of patient-provider communication in end-of-life care.
PG  - 439-41
LID - 10.1007/s11673-012-9397-4 [doi]
AB  - Successful formulation and implementation of end-of-life care requires ongoing
      communication with the patient. When patients, for reasons of general medical or 
      psychiatric illness, fail to verbally communicate, providers must be receptive to
      messages conveyed through alternate avenues of communication. We present the
      narrative of a man with schizophrenia who wished to forgo hemodialysis as a study
      in the ethical importance of attention to nonverbal communication. A multilayered
      understanding of the patient, as may be provided by both behavioral and
      motivational models, can inform the provider's ability to receive, process, and
      represent communicated content to the patient or his or her surrogate
      decision-maker.
FAU - Rice, Timothy R
AU  - Rice TR
AD  - Department of Psychiatry, The Mount Sinai Medical Center, Box 1230, 1425 Madison 
      Avenue, New York, NY 10029, USA. timothy.rice@mssm.edu
FAU - Dobry, Yuriy
AU  - Dobry Y
FAU - Novakovic, Vladan
AU  - Novakovic V
FAU - Appel, Jacob M
AU  - Appel JM
LA  - eng
PT  - Journal Article
DEP - 20121025
PL  - Netherlands
TA  - J Bioeth Inq
JT  - Journal of bioethical inquiry
JID - 101250741
SB  - IM
MH  - Humans
MH  - *Internal-External Control
MH  - Kidney Failure, Chronic/therapy
MH  - Male
MH  - *Mental Competency
MH  - Middle Aged
MH  - Palliative Care/*ethics
MH  - Professional-Patient Relations/*ethics
MH  - Renal Dialysis
MH  - Schizophrenia
MH  - Third-Party Consent/ethics
MH  - Treatment Refusal/*ethics
EDAT- 2012/11/29 06:00
MHDA- 2014/03/07 06:00
CRDT- 2012/11/29 06:00
PHST- 2011/12/26 00:00 [received]
PHST- 2012/08/27 00:00 [accepted]
PHST- 2012/11/29 06:00 [entrez]
PHST- 2012/11/29 06:00 [pubmed]
PHST- 2014/03/07 06:00 [medline]
AID - 10.1007/s11673-012-9397-4 [doi]
PST - ppublish
SO  - J Bioeth Inq. 2012 Dec;9(4):439-41. doi: 10.1007/s11673-012-9397-4. Epub 2012 Oct
      25.


PMID- 23188401
OWN - NLM
STAT- MEDLINE
DCOM- 20140305
LR  - 20211203
IS  - 1176-7529 (Print)
IS  - 1176-7529 (Linking)
VI  - 9
IP  - 4
DP  - 2012 Dec
TI  - Genetic research and aboriginal and Torres Strait Islander Australians.
PG  - 419-32
LID - 10.1007/s11673-012-9391-x [doi]
AB  - While human genetic research promises to deliver a range of health benefits to
      the population, genetic research that takes place in Indigenous communities has
      proven controversial. Indigenous peoples have raised concerns, including a lack
      of benefit to their communities, a diversion of attention and resources from
      non-genetic causes of health disparities and racism in health care, a
      reinforcement of "victim-blaming" approaches to health inequalities, and possible
      misuse of blood and tissue samples. Drawing on the international literature, this
      article reviews the ethical issues relevant to genetic research in Indigenous
      populations and considers how some of these have been negotiated in a genomic
      research project currently under way in a remote Aboriginal community. We
      consider how the different levels of Indigenous research governance operating in 
      Australia impacted on the research project and discuss whether specific
      guidelines for the conduct of genetic research in Aboriginal and Torres Strait
      Islander communities are warranted.
FAU - Kowal, Emma
AU  - Kowal E
AD  - School of Social and Political Sciences, University of Melbourne, Melbourne,
      Victoria, 3010, Australia. e.kowal@unimelb.edu.au
FAU - Pearson, Glenn
AU  - Pearson G
FAU - Rouhani, Lobna
AU  - Rouhani L
FAU - Peacock, Chris S
AU  - Peacock CS
FAU - Jamieson, Sarra E
AU  - Jamieson SE
FAU - Blackwell, Jenefer M
AU  - Blackwell JM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121012
PL  - Netherlands
TA  - J Bioeth Inq
JT  - Journal of bioethical inquiry
JID - 101250741
SB  - IM
EIN - J Bioeth Inq. 2014 Sep;11(3):403. Rouhani, Lobna [added]
MH  - Australia
MH  - Biological Specimen Banks/*ethics
MH  - Confidentiality
MH  - Dissent and Disputes
MH  - Genetic Research/*ethics
MH  - Genetics, Population/ethics
MH  - Human Genome Project
MH  - Humans
MH  - Informed Consent
MH  - *Native Hawaiian or Other Pacific Islander
MH  - Ownership
MH  - Risk
EDAT- 2012/11/29 06:00
MHDA- 2014/03/07 06:00
CRDT- 2012/11/29 06:00
PHST- 2011/04/19 00:00 [received]
PHST- 2012/08/27 00:00 [accepted]
PHST- 2012/11/29 06:00 [entrez]
PHST- 2012/11/29 06:00 [pubmed]
PHST- 2014/03/07 06:00 [medline]
AID - 10.1007/s11673-012-9391-x [doi]
PST - ppublish
SO  - J Bioeth Inq. 2012 Dec;9(4):419-32. doi: 10.1007/s11673-012-9391-x. Epub 2012 Oct
      12.


PMID- 23188400
OWN - NLM
STAT- MEDLINE
DCOM- 20140305
LR  - 20211021
IS  - 1176-7529 (Print)
IS  - 1176-7529 (Linking)
VI  - 9
IP  - 4
DP  - 2012 Dec
TI  - Cross-cultural issues in ethics: context is everything : Commentary on "The
      dilemma of revealing sensitive information on paternity status in Arabian social 
      and cultural contexts" by Abdallah A. Adlan and Henk A. M. J. ten Have.
PG  - 417-8
LID - 10.1007/s11673-012-9402-y [doi]
FAU - Komesaroff, Paul A
AU  - Komesaroff PA
AD  - Monash University Centre for Ethics in Medicine and Society, Department of
      Medicine, Alfred Hospital, Melbourne, Australia. paul.komesaroff@monash.edu
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20121113
PL  - Netherlands
TA  - J Bioeth Inq
JT  - Journal of bioethical inquiry
JID - 101250741
SB  - IM
CON - J Bioeth Inq. 2012 Dec;9(4):403-9. PMID: 23180120
MH  - Female
MH  - Genetic Research/*ethics
MH  - Humans
MH  - *Islam
MH  - Male
MH  - *Paternity
MH  - Truth Disclosure/*ethics
EDAT- 2012/11/29 06:00
MHDA- 2014/03/07 06:00
CRDT- 2012/11/29 06:00
PHST- 2012/09/07 00:00 [received]
PHST- 2012/09/08 00:00 [accepted]
PHST- 2012/11/29 06:00 [entrez]
PHST- 2012/11/29 06:00 [pubmed]
PHST- 2014/03/07 06:00 [medline]
AID - 10.1007/s11673-012-9402-y [doi]
PST - ppublish
SO  - J Bioeth Inq. 2012 Dec;9(4):417-8. doi: 10.1007/s11673-012-9402-y. Epub 2012 Nov 
      13.


PMID- 23188398
OWN - NLM
STAT- MEDLINE
DCOM- 20140305
LR  - 20211021
IS  - 1176-7529 (Print)
IS  - 1176-7529 (Linking)
VI  - 9
IP  - 4
DP  - 2012 Dec
TI  - Does nondisclosure of genetic paternity status constitute a breach of ethics?:
      Commentary on "The dilemma of revealing sensitive information on paternity status
      in Arabian social and cultural contexts" by Abdallah A. Adlan and Henk A. M. J.
      ten Have.
PG  - 413-4
LID - 10.1007/s11673-012-9401-z [doi]
FAU - Zabidi-Hussin, Z A M H
AU  - Zabidi-Hussin ZA
AD  - School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan,
      16150, Malaysia. zabidi@kb.usm.my
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20121109
PL  - Netherlands
TA  - J Bioeth Inq
JT  - Journal of bioethical inquiry
JID - 101250741
SB  - IM
CON - J Bioeth Inq. 2012 Dec;9(4):403-9. PMID: 23180120
MH  - Female
MH  - Genetic Research/*ethics
MH  - Humans
MH  - *Islam
MH  - Male
MH  - *Paternity
MH  - Truth Disclosure/*ethics
EDAT- 2012/11/29 06:00
MHDA- 2014/03/07 06:00
CRDT- 2012/11/29 06:00
PHST- 2012/09/07 00:00 [received]
PHST- 2012/09/08 00:00 [accepted]
PHST- 2012/11/29 06:00 [entrez]
PHST- 2012/11/29 06:00 [pubmed]
PHST- 2014/03/07 06:00 [medline]
AID - 10.1007/s11673-012-9401-z [doi]
PST - ppublish
SO  - J Bioeth Inq. 2012 Dec;9(4):413-4. doi: 10.1007/s11673-012-9401-z. Epub 2012 Nov 
      9.


PMID- 23188397
OWN - NLM
STAT- MEDLINE
DCOM- 20140305
LR  - 20211021
IS  - 1176-7529 (Print)
IS  - 1176-7529 (Linking)
VI  - 9
IP  - 4
DP  - 2012 Dec
TI  - Textual practices in crafting bioethics cases.
PG  - 395-401
LID - 10.1007/s11673-012-9407-6 [doi]
AB  - Bioethics case reports generally treat aspects of moral fathomability,
      characterised and addressed in different ways. This paper reads the case as a
      textual model of scenarios and draws attention to its structure, narrative shape,
      linguistic register, and the effects of tone and temporality on reader
      expectation and responsiveness. Such textual elements of case composition reflect
      authorial purpose and influence the interpretation, including moral and ethical
      interpretation, of bioethics cases.
FAU - Hurwitz, Brian
AU  - Hurwitz B
AD  - Centre for the Humanities and Health, King's College London, London, WC2R 2LS,
      UK. brian.hurwitz@kcl.ac.uk
LA  - eng
GR  - 086071/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
DEP - 20121101
PL  - Netherlands
TA  - J Bioeth Inq
JT  - Journal of bioethical inquiry
JID - 101250741
SB  - IM
MH  - *Ethics
MH  - Humans
MH  - *Narration
MH  - *Writing
PMC - PMC3508276
EDAT- 2012/11/29 06:00
MHDA- 2014/03/07 06:00
CRDT- 2012/11/29 06:00
PHST- 2012/08/29 00:00 [received]
PHST- 2012/10/10 00:00 [accepted]
PHST- 2012/11/29 06:00 [entrez]
PHST- 2012/11/29 06:00 [pubmed]
PHST- 2014/03/07 06:00 [medline]
AID - 10.1007/s11673-012-9407-6 [doi]
PST - ppublish
SO  - J Bioeth Inq. 2012 Dec;9(4):395-401. doi: 10.1007/s11673-012-9407-6. Epub 2012
      Nov 1.


PMID- 23188385
OWN - NLM
STAT- MEDLINE
DCOM- 20131125
LR  - 20211203
IS  - 1049-7323 (Print)
IS  - 1049-7323 (Linking)
VI  - 23
IP  - 2
DP  - 2013 Feb
TI  - Why women object to male circumcision to prevent HIV in a moderate-prevalence
      setting.
PG  - 180-93
LID - 10.1177/1049732312467234 [doi]
AB  - Adult male circumcision has been shown to reduce the transmission of HIV. Women's
      acceptability of male circumcision is important in Papua New Guinea's
      preparedness to introduce male circumcision, and in ethical considerations of its
      use as a biomedical technology for HIV prevention. We conducted 21 focus group
      discussions and 18 in-depth interviews with women in all four regions of Papua
      New Guinea. The majority of women objected to the introduction of male
      circumcision for three main reasons: circumcision would result in sexual risk
      compensation; circumcision goes against Christian faith; and circumcision is a
      new practice that is culturally inappropriate. A minority of women accepted male 
      circumcision for the prevention of HIV and other sexually transmitted infections,
      and for the benefit of penile hygiene and health. Women's objections to
      circumcision as a biomedical method of preventing HIV reemphasize the importance 
      of sociocultural and behavioral interventions in Papua New Guinea.
FAU - Kelly, Angela
AU  - Kelly A
AD  - Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea.
      angela.kelly@pngimr.org.pg
FAU - Kupul, Martha
AU  - Kupul M
FAU - Aeno, Herick
AU  - Aeno H
FAU - Shih, Patti
AU  - Shih P
FAU - Naketrumb, Richard
AU  - Naketrumb R
FAU - Neo, James
AU  - Neo J
FAU - Fitzgerald, Lisa
AU  - Fitzgerald L
FAU - Kaldor, John M
AU  - Kaldor JM
FAU - Siba, Peter M
AU  - Siba PM
FAU - Vallely, Andrew
AU  - Vallely A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121127
PL  - United States
TA  - Qual Health Res
JT  - Qualitative health research
JID - 9202144
MH  - Adolescent
MH  - Adult
MH  - *Attitude to Health
MH  - Blacks/*psychology
MH  - Circumcision, Male/*psychology
MH  - Culture
MH  - Female
MH  - Focus Groups
MH  - HIV Infections/*epidemiology/*prevention & control
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Middle Aged
MH  - Papua New Guinea/epidemiology
MH  - Religion
MH  - Women/*psychology
MH  - Young Adult
EDAT- 2012/11/29 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/11/29 06:00
PHST- 2012/11/29 06:00 [entrez]
PHST- 2012/11/29 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 1049732312467234 [pii]
AID - 10.1177/1049732312467234 [doi]
PST - ppublish
SO  - Qual Health Res. 2013 Feb;23(2):180-93. doi: 10.1177/1049732312467234. Epub 2012 
      Nov 27.


PMID- 23188047
OWN - NLM
STAT- MEDLINE
DCOM- 20131104
LR  - 20220331
IS  - 1476-5438 (Electronic)
IS  - 1018-4813 (Linking)
VI  - 21
IP  - 7
DP  - 2013 Jul
TI  - Non-invasive prenatal testing for single gene disorders: exploring the ethics.
PG  - 713-8
LID - 10.1038/ejhg.2012.250 [doi]
AB  - Non-invasive prenatal testing for single gene disorders is now clearly on the
      horizon. This new technology offers obvious clinical benefits such as safe
      testing early in pregnancy. Before widespread implementation, it is important to 
      consider the possible ethical implications. Four hypothetical scenarios are
      presented that highlight how ethical ideals of respect for autonomy, privacy and 
      fairness may come into play when offering non-invasive prenatal testing for
      single gene disorders. The first scenario illustrates the moral case for using
      these tests for 'information only', identifying a potential conflict between
      larger numbers of women seeking the benefits of the test and the wider social
      impact of funding tests that do not offer immediate clinical benefit. The second 
      scenario shows how the simplicity and safety of non-invasive prenatal testing
      could lead to more autonomous decision-making and, conversely, how this could
      also lead to increased pressure on women to take up testing. In the third
      scenario we show how, unless strong safeguards are put in place, offering
      non-invasive prenatal testing could be subject to routinisation with informed
      consent undermined and that woman who are newly diagnosed as carriers may be
      particularly vulnerable. The final scenario introduces the possibility of a
      conflict of the moral rights of a woman and her partner through testing for
      single gene disorders. This analysis informs our understanding of the potential
      impacts of non-invasive prenatal testing for single gene disorders on clinical
      practice and has implications for future policy and guidelines for prenatal care.
FAU - Deans, Zuzana
AU  - Deans Z
AD  - Department of Community Based Medicine, Centre for Ethics in Medicine, University
      of Bristol, Bristol, UK.
FAU - Hill, Melissa
AU  - Hill M
FAU - Chitty, Lyn S
AU  - Chitty LS
FAU - Lewis, Celine
AU  - Lewis C
LA  - eng
GR  - RP-PG-0707-10107/DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121128
PL  - England
TA  - Eur J Hum Genet
JT  - European journal of human genetics : EJHG
JID - 9302235
SB  - IM
MH  - Female
MH  - Genetic Diseases, Inborn/*diagnosis
MH  - Genetic Testing/*ethics
MH  - Humans
MH  - Pregnancy
MH  - Prenatal Diagnosis/*ethics
PMC - PMC3722948
EDAT- 2012/11/29 06:00
MHDA- 2013/11/05 06:00
CRDT- 2012/11/29 06:00
PHST- 2012/11/29 06:00 [entrez]
PHST- 2012/11/29 06:00 [pubmed]
PHST- 2013/11/05 06:00 [medline]
AID - ejhg2012250 [pii]
AID - 10.1038/ejhg.2012.250 [doi]
PST - ppublish
SO  - Eur J Hum Genet. 2013 Jul;21(7):713-8. doi: 10.1038/ejhg.2012.250. Epub 2012 Nov 
      28.


PMID- 23188043
OWN - NLM
STAT- MEDLINE
DCOM- 20131104
LR  - 20211021
IS  - 1476-5438 (Electronic)
IS  - 1018-4813 (Linking)
VI  - 21
IP  - 7
DP  - 2013 Jul
TI  - Spanish regulatory approach for biobanking.
PG  - 708-12
LID - 10.1038/ejhg.2012.249 [doi]
AB  - The Spanish regulatory framework for storage of samples for research responds to 
      most issues raised by both researchers and society regarding biobanking. The
      Spanish regulation currently foresees three possible ways in which these samples 
      are to be handled: (a) gathering for use in a specific project, (b) storage in a 
      collection, and (c) storage in a Biobank. Samples incorporated into a
      'collection' can only be used by the investigator who requested them and cannot
      be transferred to third parties or used in research projects outside the
      particular research line foreseen in the original consent. On the other hand, the
      legal entity 'Biobank' refers not only to a set of physical facilities but to the
      management of the samples stored under that label, and particularly to the
      requirements for their cession. An approach based on putting most of the
      regulatory weight on the biobank side has been chosen in order to guaranty the
      rights of the donors as well as to ease the task of the researchers. A Biobank
      requires both to be authorized and to be registered in a public Registry. The
      requirements are quite stringent, allowing for the consent to be given as 'broad'
      in scope without implying being 'blank.' In this regard, for Biobanks to justify 
      the taking on of some of the donors' rights, a key requirement is to have an
      external ethics committee supervising the adequacy of samples cession and use,
      notwithstanding the need for a previous bioethical supervision of the target
      protocol.
FAU - Arias-Diaz, Javier
AU  - Arias-Diaz J
AD  - Instituto de Salud Carlos III (ISCIII), Madrid, Spain. javardi@isciii.es
FAU - Martin-Arribas, Maria C
AU  - Martin-Arribas MC
FAU - Garcia del Pozo, Javier
AU  - Garcia del Pozo J
FAU - Alonso, Carlos
AU  - Alonso C
LA  - eng
PT  - Journal Article
DEP - 20121128
PL  - England
TA  - Eur J Hum Genet
JT  - European journal of human genetics : EJHG
JID - 9302235
SB  - IM
MH  - *Bioethics
MH  - Biological Specimen Banks/ethics/*legislation & jurisprudence/organization &
      administration
MH  - *Biomedical Research
MH  - Government Agencies
MH  - Humans
MH  - Informed Consent
MH  - Spain
PMC - PMC3722947
EDAT- 2012/11/29 06:00
MHDA- 2013/11/05 06:00
CRDT- 2012/11/29 06:00
PHST- 2012/11/29 06:00 [entrez]
PHST- 2012/11/29 06:00 [pubmed]
PHST- 2013/11/05 06:00 [medline]
AID - ejhg2012249 [pii]
AID - 10.1038/ejhg.2012.249 [doi]
PST - ppublish
SO  - Eur J Hum Genet. 2013 Jul;21(7):708-12. doi: 10.1038/ejhg.2012.249. Epub 2012 Nov
      28.


PMID- 23187973
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121129
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 6
DP  - 2012
TI  - CoMPASs: IOn programme (Care Of Memory Problems in Advanced Stages of dementia:
      Improving Our Knowledge): protocol for a mixed methods study.
LID - 10.1136/bmjopen-2012-002265 [doi]
LID - e002265 [pii]
AB  - INTRODUCTION: Approximately 700 000 people in the UK have dementia, rising to 1.2
      million by 2050; one-third of people aged over 65 will die with dementia. Good
      end-of-life care is often neglected, and detailed UK-based research on symptom
      burden and needs is lacking. Our project examines these issues from multiple
      perspectives using a rigorous and innovative design, collecting data which will
      inform the development of pragmatic interventions to improve care. METHODS AND
      ANALYSIS: To define in detail symptom burden, service provision and factors
      affecting care pathways we shall use mixed methods: prospective cohort studies of
      people with advanced dementia and their carers; workshops and interactive
      interviews with health professionals and carers, and a workshop with people with 
      early stage dementia. Interim analyses of cohort data will inform new scenarios
      for workshops and interviews. Final analysis will include cohort demographics,
      the symptom burden and health service use over the follow-up period. We shall
      explore the level and nature of unmet needs, describing how comfort and quality
      of life change over time and differences between those living in care homes and
      those remaining in their own homes. Data from workshops and interviews will be
      analysed for thematic content assisted by textual grouping software. Findings
      will inform the development of a complex intervention in the next phase of the
      research programme. ETHICS AND DISSEMINATION: Ethical approval was granted by
      National Health Service ethical committees for studies involving people with
      dementia and carers (REC refs. 12/EE/0003; 12/LO/0346), and by university ethics 
      committee for work with healthcare professionals (REC ref. 3578/001). We shall
      present our findings at conferences, and in peer-reviewed journals, prepare
      detailed reports for organisations involved with end-of-life care and dementia,
      publicising results on the Marie Curie website. A summary of the research will be
      provided to participants if requested.
FAU - Jones, Louise
AU  - Jones L
AD  - Marie Curie Palliative Care Research Unit, UCL Mental Health Sciences Unit,
      University College London Medical School, London, UK.
FAU - Harrington, Jane
AU  - Harrington J
FAU - Scott, Sharon
AU  - Scott S
FAU - Davis, Sarah
AU  - Davis S
FAU - Lord, Kathryn
AU  - Lord K
FAU - Vickerstaff, Victoria
AU  - Vickerstaff V
FAU - Round, Jeff
AU  - Round J
FAU - Candy, Bridget
AU  - Candy B
FAU - Sampson, Elizabeth L
AU  - Sampson EL
LA  - eng
GR  - MCCC-FPR-11-U/MCCC_/Marie Curie/United Kingdom
GR  - MCCC-PRO-11-U/MCCC_/Marie Curie/United Kingdom
PT  - Journal Article
DEP - 20121127
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3533091
EDAT- 2012/11/29 06:00
MHDA- 2012/11/29 06:01
CRDT- 2012/11/29 06:00
PHST- 2012/11/29 06:00 [entrez]
PHST- 2012/11/29 06:00 [pubmed]
PHST- 2012/11/29 06:01 [medline]
AID - bmjopen-2012-002265 [pii]
AID - 10.1136/bmjopen-2012-002265 [doi]
PST - epublish
SO  - BMJ Open. 2012 Nov 27;2(6). pii: bmjopen-2012-002265. doi:
      10.1136/bmjopen-2012-002265. Print 2012.


PMID- 23187119
OWN - NLM
STAT- MEDLINE
DCOM- 20130610
LR  - 20211021
IS  - 1873-6386 (Electronic)
IS  - 0160-2527 (Linking)
VI  - 36
IP  - 1
DP  - 2013 Jan-Feb
TI  - Homeward bound or bound for a home? Assessing the capacity of dementia patients
      to make decisions about hospital discharge: comparing practice with legal
      standards.
PG  - 73-82
LID - 10.1016/j.ijlp.2012.11.009 [doi]
LID - S0160-2527(12)00095-7 [pii]
AB  - BACKGROUND: This article stems from a larger project which considers ways of
      improving assessments of capacity and judgements about best interests in
      connection with people with dementia admitted to acute hospitals with respect to 
      decisions about place of residence. AIMS: Our aim is to comment on how
      assessments of residence capacity are actually performed on general hospital
      wards compared with legal standards for the assessment of capacity set out in the
      Mental Capacity Act, 2005 (MCA). METHOD: Our findings are grounded in
      ethnographic ward-based observations and in-depth interviews conducted in three
      hospital wards, in two hospitals (acute and rehabilitation), within two NHS
      healthcare trusts in the North of England over a period of nine months between
      2008 and 2009. Twenty-nine patient cases were recruited to the study. We also
      draw from broader conceptions of capacity found in domestic and international
      legal, medical, ethical and social science literature. RESULTS: Our findings
      suggest that whilst professionals profess to be familiar with broad legal
      standards governing the assessment of capacity under the MCA, these standards are
      not routinely applied in practice in general hospital settings when assessing
      capacity to decide place of residence on discharge from hospital. We discuss
      whether the criteria set out in the MCA and the guidance in its Code of Practice 
      are sufficient when assessing residence capacity, given the particular
      ambiguities and complexities of this capacity. CONCLUSIONS: We conclude by
      suggesting that more specific legal standards are required when assessing
      capacity in this particular context.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Emmett, Charlotte
AU  - Emmett C
AD  - Centre for Mental Health Law, Northumbria Law School, Northumbria University,
      City Campus East, Newcastle upon Tyne, NE1 8ST, UK.
      charlotte.emmett@northumbria.ac.uk
FAU - Poole, Marie
AU  - Poole M
FAU - Bond, John
AU  - Bond J
FAU - Hughes, Julian C
AU  - Hughes JC
LA  - eng
GR  - PB-PG-0906-11122/DH_/Department of Health/United Kingdom
PT  - Journal Article
DEP - 20121124
PL  - Netherlands
TA  - Int J Law Psychiatry
JT  - International journal of law and psychiatry
JID - 7806862
SB  - IM
MH  - *Decision Making
MH  - Dementia/*psychology
MH  - England
MH  - Focus Groups
MH  - Hospitals, Public
MH  - *Housing
MH  - Humans
MH  - Mental Competency/*legislation & jurisprudence/*psychology
MH  - *Patient Discharge
MH  - Qualitative Research
EDAT- 2012/11/29 06:00
MHDA- 2013/06/12 06:00
CRDT- 2012/11/29 06:00
PHST- 2012/11/29 06:00 [entrez]
PHST- 2012/11/29 06:00 [pubmed]
PHST- 2013/06/12 06:00 [medline]
AID - S0160-2527(12)00095-7 [pii]
AID - 10.1016/j.ijlp.2012.11.009 [doi]
PST - ppublish
SO  - Int J Law Psychiatry. 2013 Jan-Feb;36(1):73-82. doi: 10.1016/j.ijlp.2012.11.009. 
      Epub 2012 Nov 24.


PMID- 23187054
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20191112
IS  - 1526-9248 (Print)
IS  - 1526-9248 (Linking)
VI  - 22
IP  - 4
DP  - 2012 Dec
TI  - Weighing potential candidates for kidney transplant: the ethics of exclusion for 
      elevated body mass index.
PG  - 369-73
AB  - With more than 80 000 patients in the United States on waiting lists for a
      kidney-and more than 100 000 patients beginning treatment for end-stage renal
      disease each year-transplant programs must evaluate potential recipients in a
      fair and efficient manner. To this end, certain "absolute exclusion criteria"
      have been proposed to screen out candidates who will not sufficiently benefit
      from transplant. Some programs use elevated body mass index as such an exclusion 
      criterion, given that some studies have reported an association with increased
      risk of delayed graft function and acute rejection, longer hospitalization, and
      decreased overall graft survival. Upon further examination, however, elevated
      body mass index turns out to be a poor evaluative criterion for transplant
      candidates, as it is only variably associated with negative transplant outcomes. 
      Moreover, use of a body mass index cutoff is potentially discriminatory and may
      mask underlying prejudice against persons of size.
FAU - Macauley, Robert
AU  - Macauley R
AD  - University of Vermont College of Medicine, Burlington, VT, USA.
      robert.macauley@vtmednet.org
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Prog Transplant
JT  - Progress in transplantation (Aliso Viejo, Calif.)
JID - 100909380
MH  - *Body Mass Index
MH  - Humans
MH  - Kidney Transplantation/*ethnology
MH  - *Patient Selection
MH  - Prejudice
MH  - Waiting Lists
EDAT- 2012/11/29 06:00
MHDA- 2013/02/13 06:00
CRDT- 2012/11/29 06:00
PHST- 2012/11/29 06:00 [entrez]
PHST- 2012/11/29 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
AID - 3X5146644N32872L [pii]
AID - 10.7182/pit2012291 [doi]
PST - ppublish
SO  - Prog Transplant. 2012 Dec;22(4):369-73. doi: 10.7182/pit2012291.


PMID- 23186939
OWN - NLM
STAT- MEDLINE
DCOM- 20141106
LR  - 20181202
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 20
IP  - 3
DP  - 2013 May
TI  - Ethical difficulties in nursing, educational needs and attitudes about using
      ethics resources.
PG  - 348-58
LID - 10.1177/0969733012455565 [doi]
AB  - Ethical difficulties arise in healthcare practices. However, despite extensive
      research findings that demonstrate that most nurses are involved in recurrent
      ethical problems, institutions are not always able to effectively support nursing
      care professionals. The limited availability of ethics consultation services and 
      traditional nursing training fails to meet the frequent and strong requests by
      health workers to support their ethical dilemmas. A questionnaire was
      administered to 374 nurses attending a specialist training and a lifetime
      learning programme in Italy. The respondents reported a high frequency of
      ethically sensitive situations, and they described the poor development of ethics
      support and a scarcity of ethics training programmes. The results suggest the
      importance of promoting ethics services that include consultation and ethics
      training. A need for systematic ethics educational activities was identified for 
      improving the capacity of nurses to manage ethical issues in patient care.
FAU - Leuter, Cinzia
AU  - Leuter C
AD  - Department of Internal Medicine and Public Health, University of L'Aquila, Via S.
      Salvatore, Edificio Delta 6, 67100 L'Aquila, Italy.
FAU - Petrucci, Cristina
AU  - Petrucci C
FAU - Mattei, Antonella
AU  - Mattei A
FAU - Tabassi, Gianpietro
AU  - Tabassi G
FAU - Lancia, Loreto
AU  - Lancia L
LA  - eng
PT  - Journal Article
DEP - 20121127
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Adult
MH  - Clinical Competence
MH  - Cross-Sectional Studies
MH  - Ethics Consultation/*statistics & numerical data
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Italy
MH  - Male
MH  - Middle Aged
MH  - *Needs Assessment
MH  - Nurses/*psychology/statistics & numerical data
MH  - Occupational Health Services/standards
MH  - *Social Support
MH  - Specialties, Nursing/*education
MH  - Surveys and Questionnaires
MH  - Young Adult
OTO - NOTNLM
OT  - Education nursing
OT  - ethics
OT  - nurses
OT  - nursing ethics
OT  - patient care
EDAT- 2012/11/29 06:00
MHDA- 2014/11/07 06:00
CRDT- 2012/11/29 06:00
PHST- 2012/11/29 06:00 [entrez]
PHST- 2012/11/29 06:00 [pubmed]
PHST- 2014/11/07 06:00 [medline]
AID - 0969733012455565 [pii]
AID - 10.1177/0969733012455565 [doi]
PST - ppublish
SO  - Nurs Ethics. 2013 May;20(3):348-58. doi: 10.1177/0969733012455565. Epub 2012 Nov 
      27.


PMID- 23186712
OWN - NLM
STAT- MEDLINE
DCOM- 20131115
LR  - 20121128
IS  - 1875-7855 (Electronic)
IS  - 0079-6123 (Linking)
VI  - 201
DP  - 2012
TI  - Advantages and challenges of alternative sources of adult-derived stem cells for 
      brain repair in stroke.
PG  - 99-117
LID - 10.1016/B978-0-444-59544-7.00006-8 [doi]
LID - B978-0-444-59544-7.00006-8 [pii]
AB  - Considerable promise has been demonstrated by cell therapy for the treatment of
      stroke. Adult-derived stem cells avoid the ethical dilemmas of using embryonic
      and fetal stem cells and thus are the ideal type of cell to study. There are a
      number of different types of stem cells that could prove to be useful, but there 
      are potential concerns associated with each one. This review summarizes the
      current knowledge on the use of the different possible adult-derived stem cell
      types including their benefits and challenges. While the optimal conditions are
      still to be determined, these cells may prove to be at the forefront of stem cell
      research and ultimately therapy for stroke and other disorders.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Sanberg, Paul R
AU  - Sanberg PR
AD  - Center of Excellence for Aging & Brain Repair, Department Neurosurgery and Brain 
      Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA. 
      psanberg@health.usf.edu
FAU - Eve, David J
AU  - Eve DJ
FAU - Metcalf, Christopher
AU  - Metcalf C
FAU - Borlongan, Cesario V
AU  - Borlongan CV
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Prog Brain Res
JT  - Progress in brain research
JID - 0376441
SB  - IM
MH  - Adult Stem Cells/*physiology/*transplantation
MH  - Animals
MH  - Brain Injuries/*etiology/*surgery
MH  - Humans
MH  - Neural Stem Cells/physiology/transplantation
MH  - Stroke/*complications
EDAT- 2012/11/29 06:00
MHDA- 2013/11/16 06:00
CRDT- 2012/11/29 06:00
PHST- 2012/11/29 06:00 [entrez]
PHST- 2012/11/29 06:00 [pubmed]
PHST- 2013/11/16 06:00 [medline]
AID - B978-0-444-59544-7.00006-8 [pii]
AID - 10.1016/B978-0-444-59544-7.00006-8 [doi]
PST - ppublish
SO  - Prog Brain Res. 2012;201:99-117. doi: 10.1016/B978-0-444-59544-7.00006-8.


PMID- 23186575
OWN - NLM
STAT- MEDLINE
DCOM- 20130617
LR  - 20181202
IS  - 1834-7819 (Electronic)
IS  - 0045-0421 (Linking)
VI  - 57
IP  - 4
DP  - 2012 Dec
TI  - Periodontal health of dental clients in a community health setting.
PG  - 486-92
LID - 10.1111/j.1834-7819.2012.01723.x [doi]
AB  - BACKGROUND: The aim of this study was to investigate the prevalence and severity 
      of periodontal disease and possible risk factors in clients attending the Plenty 
      Valley Community Health (PVCH) dental clinic. METHODS: After ethics approval and 
      calibration of examiners, all consenting patients attending PVCH were examined
      for periodontal status using the Community Periodontal Index (CPI) system and a
      World Health Organization (WHO) probe. RESULTS: A total of 2861 patients were
      screened, of which 1751 were female. The majority of patients were Australian
      born followed by Mediterranean birth. Just under 50% brushed their teeth twice a 
      day and only 20% flossed regularly. It was found that 28.4% had CPI scores of 3
      and 4 with only 3.1% recording 0 and a widespread presence of calculus. The
      severity of periodontal status increased with age, male gender, decreased
      frequency of brushing, lower level of education, diabetes and reflected country
      of birth. CONCLUSIONS: PVCH has a higher prevalence of periodontal disease than
      the most recent national survey which reflects the population studied.
CI  - (c) 2012 Australian Dental Association.
FAU - Darby, I
AU  - Darby I
AD  - Melbourne Dental School, The University of Melbourne, Victoria. Plenty Valley
      Community Health, Epping, Victoria, Australia. idarby@unimelb.edu.au
FAU - Phan, L
AU  - Phan L
FAU - Post, M
AU  - Post M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120911
PL  - Australia
TA  - Aust Dent J
JT  - Australian dental journal
JID - 0370612
SB  - IM
MH  - Adult
MH  - Aged
MH  - Australia
MH  - Community Health Services/*statistics & numerical data
MH  - Dental Care/*statistics & numerical data
MH  - Dental Devices, Home Care/statistics & numerical data
MH  - Educational Status
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oral Hygiene/education
MH  - Periodontal Diseases/*epidemiology
MH  - *Periodontal Index
MH  - Prevalence
MH  - Risk Factors
MH  - Toothbrushing/statistics & numerical data
MH  - Young Adult
EDAT- 2012/11/29 06:00
MHDA- 2013/06/19 06:00
CRDT- 2012/11/29 06:00
PHST- 2012/11/29 06:00 [entrez]
PHST- 2012/11/29 06:00 [pubmed]
PHST- 2013/06/19 06:00 [medline]
AID - 10.1111/j.1834-7819.2012.01723.x [doi]
PST - ppublish
SO  - Aust Dent J. 2012 Dec;57(4):486-92. doi: 10.1111/j.1834-7819.2012.01723.x. Epub
      2012 Sep 11.


PMID- 23186571
OWN - NLM
STAT- MEDLINE
DCOM- 20130617
LR  - 20181202
IS  - 1834-7819 (Electronic)
IS  - 0045-0421 (Linking)
VI  - 57
IP  - 4
DP  - 2012 Dec
TI  - Clinical investigation of G-Bond resin-based adhesive to non-carious cervical
      lesions over five years.
PG  - 458-63
LID - 10.1111/j.1834-7819.2012.01729.x [doi]
AB  - BACKGROUND: The aim of this study was to evaluate the clinical performance of
      G-Bond all-in-one adhesive with Gradia Direct resin composite placed in
      non-carious cervical lesions (NCCLs) over a five-year period. METHODS:
      Forty-seven restorations were placed in NCCLs in 10 subjects (age 45-75 years)
      after written informed consent was obtained. Institutional ethical approval for
      the trial was obtained before recruitment. Restorations were placed according to 
      the manufacturer's instructions and using 50% phosphoric acid to etch uncut
      enamel margins. Patients were recalled annually for five years and restorations
      reviewed for presence and marginal staining. Photographic records were obtained
      prior to restoration, immediately after placement and at each recall. RESULTS: At
      five years, 6 of the original 10 subjects were available for recall, meaning 27
      restoration sites could be evaluated. All restorations remained intact apart for 
      one partial failure at four years. This resulted in a cumulative retention rate
      of 97.5% of restorations at five years. Marginal staining occurred around seven
      restorations during the study. Staining tended to be isolated to a few patients. 
      CONCLUSIONS: It was concluded that G-Bond with Gradia Direct resin composite
      showed excellent results over the five years of the study. This material
      combination seems very suitable for the restoration of NCCLs.
CI  - (c) 2012 Australian Dental Association.
FAU - Burrow, M F
AU  - Burrow MF
AD  - Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital,
      Sai Ying Pun, Hong Kong. mfburr58@hku.hk
FAU - Tyas, M J
AU  - Tyas MJ
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120911
PL  - Australia
TA  - Aust Dent J
JT  - Australian dental journal
JID - 0370612
RN  - 0 (Composite Resins)
RN  - 0 (Dentin-Bonding Agents)
RN  - 0 (G-Bond)
RN  - 0 (Gradia)
RN  - 0 (Methacrylates)
RN  - 0 (Resin Cements)
SB  - IM
MH  - Aged
MH  - Composite Resins/*therapeutic use
MH  - Dental Restoration, Permanent/*methods
MH  - Dentin-Bonding Agents/chemistry
MH  - Female
MH  - Humans
MH  - Male
MH  - Methacrylates/*therapeutic use
MH  - Middle Aged
MH  - Resin Cements
MH  - Time Factors
MH  - *Tooth Cervix
MH  - Tooth Diseases/*therapy
EDAT- 2012/11/29 06:00
MHDA- 2013/06/19 06:00
CRDT- 2012/11/29 06:00
PHST- 2012/11/29 06:00 [entrez]
PHST- 2012/11/29 06:00 [pubmed]
PHST- 2013/06/19 06:00 [medline]
AID - 10.1111/j.1834-7819.2012.01729.x [doi]
PST - ppublish
SO  - Aust Dent J. 2012 Dec;57(4):458-63. doi: 10.1111/j.1834-7819.2012.01729.x. Epub
      2012 Sep 11.


PMID- 23186508
OWN - NLM
STAT- MEDLINE
DCOM- 20130513
LR  - 20140512
IS  - 1532-2491 (Electronic)
IS  - 1082-6084 (Linking)
VI  - 47
IP  - 13-14
DP  - 2012 Nov-Dec
TI  - Failures in substance use surveys.
PG  - 1675-82
LID - 10.3109/10826084.2012.706161 [doi]
AB  - This paper reviews some of the potential sources of failure in surveys concerned 
      with substance use. These failures are both conceptual and methodological in
      nature. Conceptual failures include nonuse and misuse of survey data, the
      inability of these data to detect emerging substance use trends and problems, and
      relevant ethical concerns. Methodological failures include sampling, coverage,
      nonresponse, and measurement and processing errors, which are indigenous at some 
      level to all epidemiologic surveys. Consideration of these is necessary if survey
      data are to be appropriately used for their intended purposes.
FAU - Johnson, Timothy P
AU  - Johnson TP
AD  - Survey Research Laboratory, University of Illinois at Chicago, Chicago, Illinois 
      60607, USA. timj@uic.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Subst Use Misuse
JT  - Substance use & misuse
JID - 9602153
SB  - IM
CIN - Subst Use Misuse. 2012 Nov-Dec;47(13-14):1683-4. PMID: 23186509
CIN - Subst Use Misuse. 2012 Nov-Dec;47(13-14):1685-6. PMID: 23186510
CIN - Subst Use Misuse. 2014 May;49(6):775-6. PMID: 24328843
MH  - *Epidemiologic Methods
MH  - Health Surveys/*methods
MH  - Humans
MH  - Substance-Related Disorders/*epidemiology
MH  - United States/epidemiology
EDAT- 2012/11/29 06:00
MHDA- 2013/05/15 06:00
CRDT- 2012/11/29 06:00
PHST- 2012/11/29 06:00 [entrez]
PHST- 2012/11/29 06:00 [pubmed]
PHST- 2013/05/15 06:00 [medline]
AID - 10.3109/10826084.2012.706161 [doi]
PST - ppublish
SO  - Subst Use Misuse. 2012 Nov-Dec;47(13-14):1675-82. doi:
      10.3109/10826084.2012.706161.


PMID- 23186365
OWN - NLM
STAT- MEDLINE
DCOM- 20131206
LR  - 20220318
IS  - 1365-2702 (Electronic)
IS  - 0962-1067 (Linking)
VI  - 22
IP  - 9-10
DP  - 2013 May
TI  - Validation of the core elements of perioperative nursing.
PG  - 1391-9
LID - 10.1111/j.1365-2702.2012.04220.x [doi]
AB  - AIMS AND OBJECTIVES: To define the core elements of perioperative nursing.
      BACKGROUND: To measure the nursing care intensity in operating departments and
      day surgery units, a consensus on the content of perioperative nursing is
      required. The core elements of perioperative nursing were initially defined based
      on literature and the clinical expertise of the national workgroup. Suggested
      core elements were verified in this study. Because healthcare systems constantly 
      suffer from limited resources, while patients are legitimated and ethically
      justified good nursing care, it is essential to produce reliable information for 
      resource allocation. DESIGN: Descriptive survey using Delphi technique. METHODS: 
      The purposeful sample of 55 experts was invited to participate in the Delphi
      panel to evaluate the suggested core elements of perioperative nursing. Two
      nationwide Delphi rounds were conducted. The response rates were 89% and 49%,
      respectively. Content Validity Index was calculated for each component. RESULTS: 
      The Delphi panel accepted the suggested core elements that were seen describing
      the core of perioperative nursing. CONCLUSION: The initially defined core
      elements of perioperative nursing were verified in this study, with the core
      elements describing patient's safety as crucial in perioperative nursing. Those
      concerning patients' needs of information, communication with significant others,
      patients' coping mechanisms and mental well-being or administrating basic care - 
      for example hygiene - were not seen to be as fundamental as those describing
      physiological needs. RELEVANCE TO CLINICAL PRACTICE: The results of this study
      can be used as an initial step when constructing an instrument for measuring the 
      nursing care intensity in perioperative settings. In the future, the instrument
      may provide objective evidence of nursing care intensity and thus facilitate
      resource allocation. A further significance of this study lies in its potential
      to make perioperative nursing visible, so the nursing outcomes may be evaluated
      and proved.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Rauta, Satu
AU  - Rauta S
AD  - Helsinki University Central Hospital, Helsinki, Finland. satu.rauta@hus.fi
FAU - Salantera, Sanna
AU  - Salantera S
FAU - Nivalainen, Jarmo
AU  - Nivalainen J
FAU - Junttila, Kristiina
AU  - Junttila K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20121127
PL  - England
TA  - J Clin Nurs
JT  - Journal of clinical nursing
JID - 9207302
MH  - Adult
MH  - Aged
MH  - Delphi Technique
MH  - Health Care Rationing
MH  - Humans
MH  - Middle Aged
MH  - *Perioperative Nursing
EDAT- 2012/11/29 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/11/29 06:00
PHST- 2012/11/29 06:00 [entrez]
PHST- 2012/11/29 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1111/j.1365-2702.2012.04220.x [doi]
PST - ppublish
SO  - J Clin Nurs. 2013 May;22(9-10):1391-9. doi: 10.1111/j.1365-2702.2012.04220.x.
      Epub 2012 Nov 27.


PMID- 23186272
OWN - NLM
STAT- MEDLINE
DCOM- 20130620
LR  - 20161018
IS  - 1939-1676 (Electronic)
IS  - 0891-6640 (Linking)
VI  - 27
IP  - 1
DP  - 2013 Jan-Feb
TI  - A single-blood-sample method using inulin for estimating feline glomerular
      filtration rate.
PG  - 17-21
LID - 10.1111/jvim.12017 [doi]
AB  - BACKGROUND: Application of a multisample method using inulin to estimate
      glomerular filtration rate (GFR) in cats is cumbersome. OBJECTIVES: To establish 
      a simplified procedure to estimate GFR in cats, a single-blood-sample method
      using inulin was compared with a conventional 3-sample method. ANIMALS: Nine cats
      including 6 clinically healthy cats and 3 cats with spontaneous chronic kidney
      disease. METHODS: Retrospective study. Inulin was administered as an intravenous 
      bolus at 50 mg/kg to cats, and blood was collected at 60, 90, and 120 minutes
      later for the 3-sample method. Serum inulin concentrations were colorimetrically 
      determined by an autoanalyzer method. The GFR in the single-blood-sample method
      was calculated from the dose injected, serum concentration, sampling time, and
      estimated volume of distribution on the basis of the data of the 3-sample method.
      RESULTS: An excellent correlation was observed (r = 0.99, P = .0001) between GFR 
      values estimated by the single-blood-sample and 3-sample methods. CONCLUSIONS AND
      CLINICAL IMPORTANCE: The single-blood-sample method using inulin provides a
      practicable and ethical alternative for estimating glomerular filtration rate in 
      cats.
CI  - Copyright (c) 2012 by the American College of Veterinary Internal Medicine.
FAU - Katayama, M
AU  - Katayama M
AD  - Department of Veterinary Clinical Medicine, Iwate University, Morioka, Japan.
FAU - Saito, J
AU  - Saito J
FAU - Katayama, R
AU  - Katayama R
FAU - Yamagishi, N
AU  - Yamagishi N
FAU - Murayama, I
AU  - Murayama I
FAU - Miyano, A
AU  - Miyano A
FAU - Furuhama, K
AU  - Furuhama K
LA  - eng
PT  - Journal Article
DEP - 20121127
PL  - United States
TA  - J Vet Intern Med
JT  - Journal of veterinary internal medicine
JID - 8708660
RN  - 9005-80-5 (Inulin)
SB  - IM
MH  - Animals
MH  - Blood Specimen Collection/veterinary
MH  - Cats/*physiology
MH  - Colorimetry/veterinary
MH  - Glomerular Filtration Rate/physiology/*veterinary
MH  - *Inulin/blood/pharmacokinetics
MH  - Kidney/*physiology
MH  - Renal Insufficiency, Chronic/blood/physiopathology/*veterinary
MH  - Retrospective Studies
EDAT- 2012/11/29 06:00
MHDA- 2013/06/21 06:00
CRDT- 2012/11/29 06:00
PHST- 2012/01/11 00:00 [received]
PHST- 2012/09/20 00:00 [revised]
PHST- 2012/10/10 00:00 [accepted]
PHST- 2012/11/29 06:00 [entrez]
PHST- 2012/11/29 06:00 [pubmed]
PHST- 2013/06/21 06:00 [medline]
AID - 10.1111/jvim.12017 [doi]
PST - ppublish
SO  - J Vet Intern Med. 2013 Jan-Feb;27(1):17-21. doi: 10.1111/jvim.12017. Epub 2012
      Nov 27.


PMID- 23185950
OWN - NLM
STAT- MEDLINE
DCOM- 20130108
LR  - 20121127
IS  - 1029-4864 (Print)
IS  - 1029-4864 (Linking)
VI  - 67
IP  - 5
DP  - 2012 Jun
TI  - Dental ethics case 22. Sexual harassment in the dental practice.
PG  - 234-5
FAU - Naidoo, S
AU  - Naidoo S
AD  - Faculty of Dentistry, University of the Western Cape, Department of Community
      Dentistry, Private Bag X1, Tygerberg 7505. suenaidoo@uwc.ac.za
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - SADJ
JT  - SADJ : journal of the South African Dental Association = tydskrif van die
      Suid-Afrikaanse Tandheelkundige Vereniging
JID - 9812497
MH  - Anesthesia, Dental/ethics
MH  - Anesthesia, General/ethics
MH  - Conscious Sedation/ethics
MH  - Dentist-Patient Relations/ethics
MH  - Dentists/*ethics/legislation & jurisprudence
MH  - *Ethics, Dental
MH  - Female
MH  - Humans
MH  - Interprofessional Relations/ethics
MH  - Male
MH  - Medical Chaperones
MH  - Professional Practice/*ethics/legislation & jurisprudence
MH  - Professional-Patient Relations/ethics
MH  - Sexual Harassment/*ethics/legislation & jurisprudence/prevention & control
EDAT- 2012/11/29 06:00
MHDA- 2013/01/09 06:00
CRDT- 2012/11/29 06:00
PHST- 2012/11/29 06:00 [entrez]
PHST- 2012/11/29 06:00 [pubmed]
PHST- 2013/01/09 06:00 [medline]
PST - ppublish
SO  - SADJ. 2012 Jun;67(5):234-5.


PMID- 23185948
OWN - NLM
STAT- MEDLINE
DCOM- 20130108
LR  - 20131121
IS  - 1029-4864 (Print)
IS  - 1029-4864 (Linking)
VI  - 67
IP  - 5
DP  - 2012 Jun
TI  - Students' vulnerability in educational research.
PG  - 222, 224-7
AB  - Dental teaching institutions in South Africa recently implemented
      "learner-centred" curricula and expected educators to alter their teaching styles
      accordingly, but perhaps without providing adequate training in this paedagogical
      philosophy. At the same time, the lecturers were required to conduct
      evidence-based research to evaluate the outcomes. Thus, clinicians/lecturers also
      became researchers, using their own students or student material for assessment
      purposes. Previously, this form of educational research, which was carried out in
      normal academic settings, was not subject to review by Institutional Review
      Boards (IRB). However, concerns have risen that learners may be a vulnerable
      population due to their position in the academic institution, and the power and
      knowledge differentials that exist between them and the lecturer/researcher. This
      raises ethical concerns regarding their autonomy and ability to provide free,
      voluntary, informed consent to be research participants. This paper questions
      whether educational research may lead to student vulnerability, and proposes some
      recommendations for educators and institutions involved in educational research.
FAU - Sykes, L M
AU  - Sykes LM
AD  - Department of Prosthodontics, University of Pretoria. leanne.sykes@up.ac.za
FAU - Dullabh, H
AU  - Dullabh H
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - South Africa
TA  - SADJ
JT  - SADJ : journal of the South African Dental Association = tydskrif van die
      Suid-Afrikaanse Tandheelkundige Vereniging
JID - 9812497
MH  - Coercion
MH  - Dental Research/*education/ethics
MH  - Education, Dental/*ethics
MH  - *Ethics, Research
MH  - Faculty, Dental
MH  - Humans
MH  - Informed Consent
MH  - Interpersonal Relations
MH  - Motivation/ethics
MH  - Personal Autonomy
MH  - Research Subjects
MH  - Risk Assessment
MH  - South Africa
MH  - *Students, Dental
MH  - Teaching/methods
MH  - Volunteers
EDAT- 2012/11/29 06:00
MHDA- 2013/01/09 06:00
CRDT- 2012/11/29 06:00
PHST- 2012/11/29 06:00 [entrez]
PHST- 2012/11/29 06:00 [pubmed]
PHST- 2013/01/09 06:00 [medline]
PST - ppublish
SO  - SADJ. 2012 Jun;67(5):222, 224-7.


PMID- 23185943
OWN - NLM
STAT- MEDLINE
DCOM- 20130108
LR  - 20191210
IS  - 1029-4864 (Print)
IS  - 1029-4864 (Linking)
VI  - 67
IP  - 6
DP  - 2012 Jul
TI  - Dental ethics case 23. The ethics of advertising in dentistry.
PG  - 284-6
FAU - Naidoo, S
AU  - Naidoo S
AD  - Faculty of Dentistry, University of the Western Cape. Department of Community
      Dentistry, Private Bag X1, Tygerberg 7505. suenaidoo@uwc.ac.za
LA  - eng
PT  - Journal Article
PL  - South Africa
TA  - SADJ
JT  - SADJ : journal of the South African Dental Association = tydskrif van die
      Suid-Afrikaanse Tandheelkundige Vereniging
JID - 9812497
MH  - Advertising/*ethics
MH  - Dental Care/ethics
MH  - Dentist-Patient Relations/ethics
MH  - Dentists/ethics
MH  - *Ethics, Dental
MH  - Humans
MH  - Marketing of Health Services/ethics
MH  - Social Responsibility
MH  - South Africa
MH  - Trust
MH  - Truth Disclosure/ethics
EDAT- 2012/11/29 06:00
MHDA- 2013/01/09 06:00
CRDT- 2012/11/29 06:00
PHST- 2012/11/29 06:00 [entrez]
PHST- 2012/11/29 06:00 [pubmed]
PHST- 2013/01/09 06:00 [medline]
PST - ppublish
SO  - SADJ. 2012 Jul;67(6):284-6.


PMID- 23185717
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121128
LR  - 20211021
IS  - 2152-5250 (Electronic)
IS  - 2152-5250 (Linking)
VI  - 3
IP  - 5
DP  - 2012 Oct
TI  - Diagnosis and management of chronic kidney disease in the elderly: a field of
      ongoing debate.
PG  - 360-72
AB  - Chronic kidney disease (CKD) is rather common in elderly adults who comprise the 
      fastest growing subset of patients with end-stage renal disease (ESRD). At
      present, there are no specific guidelines and recommendations regarding early
      identification and management of elderly with CKD and the current CKD
      classification system may overestimate its exact prevalence. Screening strategies
      based either in a more accurate formula of estimation of GFR alone, or preferably
      in combination with proteinuria are urgently needed in order to raise awareness
      and to promote early diagnosis of CKD in the elderly. The number of elderly
      dialysis patients is also increasing and may lead to severe socio-economic
      problems worldwide. Both hemodialysis and peritoneal dialysis can sustain life,
      but present various disadvantages. There is a trend for home based dialysis
      therapies but the results are based on a small number of patients. Recent reports
      indicate that dialysis may not provide a clear benefit over non-dialysis
      regarding survival and quality of life issues, especially in the presence of
      extensive comorbidities. Current practices around the world regarding access to
      dialysis in the elderly are rather controversial, reflecting each country's
      health policies and ethical patterns. Although advanced age should not be
      considered as an absolute contraindication for kidney transplantation, it is not 
      frequently offered in elderly ESRD patients due to the shortage of renal grafts. 
      Global judgment of all physical and mental/psychological issues and full informed
      consent regarding possible complications are mandatory before listing elderly
      ESRD patients for kidney transplantation. As scientific evidence is rather
      scarce, there is an urgent need for prospective studies and an individualized
      approach for the diagnosis and treatment of the elderly CKD patients, in order to
      optimize care and improve quality of life in this special population.
FAU - Dousdampanis, Periklis
AU  - Dousdampanis P
AD  - Kyanous Stavros Patron Dialysis Unit, Patras, Greece.
FAU - Trigka, Konstantina
AU  - Trigka K
FAU - Fourtounas, Costas
AU  - Fourtounas C
LA  - eng
PT  - Journal Article
DEP - 20120806
PL  - United States
TA  - Aging Dis
JT  - Aging and disease
JID - 101540533
PMC - PMC3501392
OTO - NOTNLM
OT  - Chronic kidney disease
OT  - elderly
OT  - hemodialysis
OT  - peritoneal dialysis
OT  - renal transplantation
EDAT- 2012/11/28 06:00
MHDA- 2012/11/28 06:01
CRDT- 2012/11/28 06:00
PHST- 2012/07/17 00:00 [received]
PHST- 2012/08/03 00:00 [revised]
PHST- 2012/08/03 00:00 [accepted]
PHST- 2012/11/28 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2012/11/28 06:01 [medline]
PST - ppublish
SO  - Aging Dis. 2012 Oct;3(5):360-72. Epub 2012 Aug 6.


PMID- 23185138
OWN - NLM
STAT- MEDLINE
DCOM- 20130422
LR  - 20220409
IS  - 1549-1676 (Electronic)
IS  - 1549-1277 (Linking)
VI  - 9
IP  - 11
DP  - 2012
TI  - The Ottawa Statement on the Ethical Design and Conduct of Cluster Randomized
      Trials.
PG  - e1001346
LID - 10.1371/journal.pmed.1001346 [doi]
FAU - Weijer, Charles
AU  - Weijer C
AD  - Rotman Institute of Philosophy, Department of Philosophy, Western University,
      London, Ontario, Canada. cweijer@uwo.ca
FAU - Grimshaw, Jeremy M
AU  - Grimshaw JM
FAU - Eccles, Martin P
AU  - Eccles MP
FAU - McRae, Andrew D
AU  - McRae AD
FAU - White, Angela
AU  - White A
FAU - Brehaut, Jamie C
AU  - Brehaut JC
FAU - Taljaard, Monica
AU  - Taljaard M
CN  - Ottawa Ethics of Cluster Randomized Trials Consensus Group
LA  - eng
GR  - MOP85066/Canadian Institutes of Health Research/Canada
GR  - MOP89790/Canadian Institutes of Health Research/Canada
PT  - Guideline
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121120
PL  - United States
TA  - PLoS Med
JT  - PLoS medicine
JID - 101231360
SB  - IM
CIN - J Clin Epidemiol. 2019 Dec;116:146-149. PMID: 31449856
MH  - *Cluster Analysis
MH  - *Epidemiologic Research Design
MH  - Humans
MH  - Randomized Controlled Trials as Topic/*ethics/*methods
PMC - PMC3502500
IR  - Althabe F
FIR - Althabe, Fernando
IR  - Binik A
FIR - Binik, Ariella
IR  - Brown JB
FIR - Brown, Judith Belle
IR  - Boruch R
FIR - Boruch, Robert
IR  - Brehaut JC
FIR - Brehaut, Jamie C
IR  - Chaudhry S
FIR - Chaudhry, Shazia
IR  - Donner A
FIR - Donner, Allan
IR  - Dubois-Flynn G
FIR - Dubois-Flynn, Genevieve
IR  - Eccles MP
FIR - Eccles, Martin P
IR  - Edwards S
FIR - Edwards, Sarah
IR  - Elbourne D
FIR - Elbourne, Diana
IR  - Eldridge S
FIR - Eldridge, Sandra
IR  - Forster D
FIR - Forster, David
IR  - Gallo A
FIR - Gallo, Antonio
IR  - Grimshaw JM
FIR - Grimshaw, Jeremy M
IR  - Kiefe C
FIR - Kiefe, Catarina
IR  - Kimmelman J
FIR - Kimmelman, Jonathan
IR  - Lin M
FIR - Lin, Melody
IR  - Loder E
FIR - Loder, Elizabeth
IR  - Lohr K
FIR - Lohr, Kathleen
IR  - McRae AD
FIR - McRae, Andrew D
IR  - Naughton ES
FIR - Naughton, Eileen S
IR  - Polson RJ
FIR - Polson, Rex J
IR  - Saginur R
FIR - Saginur, Raphael
IR  - Saxena A
FIR - Saxena, Abha
IR  - Spence J
FIR - Spence, Julie
IR  - Taljaard M
FIR - Taljaard, Monica
IR  - Weijer C
FIR - Weijer, Charles
IR  - White A
FIR - White, Angela
IR  - White G
FIR - White, Gerald
IR  - Zwarenstein M
FIR - Zwarenstein, Merrick
EDAT- 2012/11/28 06:00
MHDA- 2013/04/23 06:00
CRDT- 2012/11/28 06:00
PHST- 2012/11/28 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/04/23 06:00 [medline]
AID - 10.1371/journal.pmed.1001346 [doi]
AID - PMEDICINE-D-12-01569 [pii]
PST - ppublish
SO  - PLoS Med. 2012;9(11):e1001346. doi: 10.1371/journal.pmed.1001346. Epub 2012 Nov
      20.


PMID- 23184926
OWN - NLM
STAT- MEDLINE
DCOM- 20130527
LR  - 20171116
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 4
DP  - 2013 Apr
TI  - Is age the limit for human-assisted reproduction techniques? 'Yes', said an
      Italian judge.
PG  - 250-2
LID - 10.1136/medethics-2011-100358 [doi]
AB  - Although use of assisted reproduction techniques was examined by an ad hoc act in
      2004 in Italy, there are many opposing views about ethical and economic
      implications of the technologies dealing with infertility and sterility problems.
      In this paper, the authors examine a recent judge's decision that ordered the
      removal and subsequent adoption of a 1-year-old child because her parents were
      considered too old to be parents. The couple had had recourse to heterologous
      artificial insemination abroad and decided to give birth in Italy. The judgement 
      deals with and discusses the complex issue of the right to procreate in order to 
      balance the opportunities offered by scientific progress with the unborn child's 
      condition.
FAU - Gulino, Matteo
AU  - Gulino M
AD  - Department of Anatomical, Histological, Forensic and Orthopaedic Sciences,
      University of Rome Sapienza, 336 Viale Regina Elena, Rome, Lazio 00161, Italy.
      matteo_gulino@libero.it
FAU - Pacchiarotti, Arianna
AU  - Pacchiarotti A
FAU - Vergallo, Gianluca Montanari
AU  - Vergallo GM
FAU - Frati, Paola
AU  - Frati P
LA  - eng
PT  - Journal Article
DEP - 20121126
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
CIN - Reprod Biomed Online. 2013 Aug;27(2):118-20. PMID: 23768620
CIN - Reprod Biomed Online. 2013 Aug;27(2):121-4. PMID: 23768624
MH  - *Adoption
MH  - Adult
MH  - Age Factors
MH  - *Aging
MH  - Contraindications
MH  - Female
MH  - Humans
MH  - Infertility
MH  - Italy
MH  - Middle Aged
MH  - *Parents
MH  - Personal Autonomy
MH  - Pregnancy
MH  - Reproductive Rights/*legislation & jurisprudence
MH  - Reproductive Techniques, Assisted/*legislation & jurisprudence
EDAT- 2012/11/28 06:00
MHDA- 2013/05/29 06:00
CRDT- 2012/11/28 06:00
PHST- 2012/11/28 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/05/29 06:00 [medline]
AID - medethics-2011-100358 [pii]
AID - 10.1136/medethics-2011-100358 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Apr;39(4):250-2. doi: 10.1136/medethics-2011-100358. Epub 2012
      Nov 26.


PMID- 23184909
OWN - NLM
STAT- MEDLINE
DCOM- 20130617
LR  - 20220316
IS  - 1873-734X (Electronic)
IS  - 1010-7940 (Linking)
VI  - 43
IP  - 2
DP  - 2013 Feb
TI  - State of the art in paediatric heart transplantation: the Berlin experience.
PG  - 258-67
LID - 10.1093/ejcts/ezs588 [doi]
AB  - Enormous progress has been made in paediatric heart transplantation since the
      first unsuccessful effort by Kantrowitz in 1967. Early reports of children
      undergoing heart transplantation showed alarmingly high perioperative mortality
      rates of 25-60%, with the diagnosis of congenital heart disease (CHD)
      representing a particularly high-risk subset compared with cardiomyopathy. Many
      of these early failures were related to poor patient selection, suboptimal
      immunosuppression and technical problems. We learned a great deal from these
      earlier difficulties. Presently, with more refined techniques, better-defined
      patient selection criteria, excellent graft rejection monitoring and optimal
      immunosuppression, the ISHLT 2011 registry reported a 10-year survival rate of
      60% for patients transplanted for end-stage CHD and >70% for those transplanted
      for cardiomyopathy. The technical dilemmas in complex CHD were overcome by
      surgical ingenuity and creativity, innovative solutions and careful surgical
      planning, adapting the complex recipient anatomy to the normal donor anatomy. The
      miniaturized Berlin Heart pulsatile ventricular assist devices in children as a
      bridge to transplantation have revolutionized treatment and become a significant 
      contribution in heart-failure therapy. The intramyocardial electrogram and
      echocardiographic strain rate imaging have been employed as non-invasive
      techniques of rejection monitoring. Immunosuppressive drugs have a major impact
      on the development and progression of cardiac allograft vasculopathy, the main
      cause of cardiac allograft loss and a leading cause of mortality after the first 
      year post-transplantation. The questions of whether a transplanted heart in a
      newborn grows to adult size along with the child and whether the dimensional
      cardiac growth allows adequate function over time have been largely answered in
      our previous investigations. As more transplanted children reach adulthood,
      concerns about their life expectancy when they have reached 10 years of life
      post-transplant are raised, particularly with respect to establishing
      partnerships and families, their ability to earn a living and the fulfilment of
      personal life perspectives. Some heart-transplanted patients require
      retransplantation to remain alive. The disparity between the demand for and
      supply of donor hearts makes retransplantation an ethical issue. We 'do not
      refuse' any patient who needs retransplantation. Mechanical circulatory support
      devices for long-term use are now largely available to accommodate such cases.
FAU - Hetzer, Roland
AU  - Hetzer R
AD  - Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, 
      Berlin, Germany.
FAU - Weng, Yuguo
AU  - Weng Y
FAU - Delmo Walter, Eva Maria
AU  - Delmo Walter EM
LA  - eng
PT  - Journal Article
DEP - 20121125
PL  - Germany
TA  - Eur J Cardiothorac Surg
JT  - European journal of cardio-thoracic surgery : official journal of the European
      Association for Cardio-thoracic Surgery
JID - 8804069
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Administration, Oral
MH  - Adolescent
MH  - Age Factors
MH  - Berlin
MH  - Cardiomyopathies/mortality/*surgery
MH  - Child
MH  - Child, Preschool
MH  - Drug Administration Schedule
MH  - Extracorporeal Membrane Oxygenation/mortality/statistics & numerical data
MH  - Graft Rejection/prevention & control
MH  - Heart Defects, Congenital/mortality/*surgery
MH  - Heart Transplantation/*methods/mortality
MH  - Heart-Assist Devices/statistics & numerical data
MH  - Humans
MH  - Immunosuppressive Agents/administration & dosage/adverse effects
MH  - Infant
MH  - Infusions, Intravenous
MH  - Postoperative Complications/etiology/mortality
MH  - Survival Analysis
MH  - Survival Rate
EDAT- 2012/11/28 06:00
MHDA- 2013/06/19 06:00
CRDT- 2012/11/28 06:00
PHST- 2012/11/28 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/06/19 06:00 [medline]
AID - ezs588 [pii]
AID - 10.1093/ejcts/ezs588 [doi]
PST - ppublish
SO  - Eur J Cardiothorac Surg. 2013 Feb;43(2):258-67. doi: 10.1093/ejcts/ezs588. Epub
      2012 Nov 25.


PMID- 23184854
OWN - NLM
STAT- MEDLINE
DCOM- 20140303
LR  - 20181202
IS  - 1471-8391 (Electronic)
IS  - 0007-1420 (Linking)
VI  - 105
DP  - 2013
TI  - Placenta as a reservoir of stem cells: an underutilized resource?
PG  - 43-68
LID - 10.1093/bmb/lds033 [doi]
AB  - INTRODUCTION: Both embryonic and adult tissues are sources of stem cells with
      therapeutic potential but with some limitations in the clinical practice such as 
      ethical considerations, difficulty in obtaining and tumorigenicity. As an
      alternative, the placenta is a foetal tissue that can be obtained during
      gestation and at term, and it represents a reservoir of stem cells with various
      potential. SOURCES OF DATA: We reviewed the relevant literature concerning the
      main stem cells that populate the placenta. AREAS OF AGREEMENT: Recently, the
      placenta has become useful source of stem cells that offer advantages in terms of
      proliferation and plasticity when compared with adult cells and permit to
      overcome the ethical and safety concern inherent in embryonic stem cells. In
      addition, the placenta has the advantage of containing epithelia, haematopoietic 
      and mesenchymal stem cells. These stem cells possess immunosuppressive properties
      and have the capacity of suppress in vivo inflammatory responses. AREAS OF
      CONTROVERSY: Some studies describe a subpopulation of placenta stem cells
      expressing pluripotency markers, but for other studies, it is not clear whether
      pluripotent stem cells are present during gestation beyond the first few weeks.
      Particularly, the expression of some pluripotency markers such as SSEA-3,
      TRA-1-60 and TRA-1-81 has been reported by us, but not by others. GROWING POINTS:
      Placenta stem cells could be of great importance after delivery for banking for
      autologous and allogeneic applications. The beneficial effects of these cells may
      be due to secretion of bioactive molecules that act through paracrine actions
      promoting beneficial effects. AREAS TIMELY FOR DEVELOPING RESEARCH: Understanding
      the role of placenta stem cells during pregnancy and their paracrine actions
      could help in the study of some diseases that affect the placenta during
      pregnancy.
FAU - Pipino, Caterina
AU  - Pipino C
AD  - University College London, 30 Guilford Street, London, UK.
FAU - Shangaris, Panicos
AU  - Shangaris P
FAU - Resca, Elisa
AU  - Resca E
FAU - Zia, Silvia
AU  - Zia S
FAU - Deprest, Jan
AU  - Deprest J
FAU - Sebire, Neil J
AU  - Sebire NJ
FAU - David, Anna L
AU  - David AL
FAU - Guillot, Pascale V
AU  - Guillot PV
FAU - De Coppi, Paolo
AU  - De Coppi P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121125
PL  - England
TA  - Br Med Bull
JT  - British medical bulletin
JID - 0376542
SB  - IM
MH  - Adult
MH  - Animals
MH  - Cell Differentiation
MH  - Epithelial Cells/cytology/metabolism
MH  - Female
MH  - Health Resources/*statistics & numerical data
MH  - Humans
MH  - Mesenchymal Stem Cells/cytology/metabolism
MH  - Mice
MH  - Placenta/cytology/*metabolism
MH  - Pluripotent Stem Cells/cytology/metabolism
MH  - Pregnancy
MH  - Rats
MH  - Stem Cells/*cytology/metabolism
EDAT- 2012/11/28 06:00
MHDA- 2014/03/04 06:00
CRDT- 2012/11/28 06:00
PHST- 2012/11/28 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2014/03/04 06:00 [medline]
AID - lds033 [pii]
AID - 10.1093/bmb/lds033 [doi]
PST - ppublish
SO  - Br Med Bull. 2013;105:43-68. doi: 10.1093/bmb/lds033. Epub 2012 Nov 25.


PMID- 23184790
OWN - NLM
STAT- MEDLINE
DCOM- 20130110
LR  - 20220321
IS  - 2192-2640 (Print)
IS  - 2192-2640 (Linking)
VI  - 1
IP  - 5
DP  - 2012 Sep
TI  - A rapid screening method for wound dressing by cell-on-a-chip device.
PG  - 560-6
LID - 10.1002/adhm.201200008 [doi]
AB  - This report demonstrates an in vitro method for screening wound dressing
      candidates that can minimize the use of animals for developing better methods for
      wound care. The development of materials and formulations for wound dressings, an
      important application of biomaterials, is laboriously and ethically challenging
      because of the use of a large number of animals. A method for rapid and effective
      screening of wound dressings in vitro, therefore, is in great need. A
      cell-on-a-chip model was used to simulate the cutaneous wound in vitro and screen
      the performances of several electrospun fibrous wound dressings in enhancing
      wound healing. For comparison, the performances of wound dressings were also
      evaluated in a rat model. It was found that the results acquired by microchip
      model corroborates well with animal experiments. It is the first time, as far as 
      we know, that a good correlation between in vitro and in vivo results is reported
      for fibrous wound dressings. The cell-on-a-chip wound model we developed here may
      change the way that scientists screen candidates for wound dressings.
CI  - Copyright (c) 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Zhao, Qilong
AU  - Zhao Q
AD  - CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety National
      Center for NanoScience and Technology, 11 Beiyitiao, ZhongGuanCun, Beijing
      100190, China.
FAU - Wang, Shiwen
AU  - Wang S
FAU - Xie, Yunyan
AU  - Xie Y
FAU - Zheng, Wenfu
AU  - Zheng W
FAU - Wang, Zhuo
AU  - Wang Z
FAU - Xiao, Le
AU  - Xiao L
FAU - Zhang, Wei
AU  - Zhang W
FAU - Jiang, Xingyu
AU  - Jiang X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120608
PL  - Germany
TA  - Adv Healthc Mater
JT  - Advanced healthcare materials
JID - 101581613
RN  - 0 (ACKR1 protein, human)
RN  - 0 (Duffy Blood-Group System)
RN  - 0 (Receptors, Cell Surface)
SB  - IM
MH  - 3T3 Cells
MH  - Animals
MH  - *Bandages
MH  - Biological Assay/*instrumentation
MH  - Duffy Blood-Group System
MH  - Equipment Design
MH  - Equipment Failure Analysis
MH  - *Lab-On-A-Chip Devices
MH  - Madin Darby Canine Kidney Cells
MH  - Male
MH  - Mice
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Cell Surface
MH  - Skin/*injuries/*physiopathology
MH  - Wound Healing/*physiology
EDAT- 2012/11/28 06:00
MHDA- 2013/01/11 06:00
CRDT- 2012/11/28 06:00
PHST- 2012/01/11 00:00 [received]
PHST- 2012/02/13 00:00 [revised]
PHST- 2012/11/28 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/01/11 06:00 [medline]
AID - 10.1002/adhm.201200008 [doi]
PST - ppublish
SO  - Adv Healthc Mater. 2012 Sep;1(5):560-6. doi: 10.1002/adhm.201200008. Epub 2012
      Jun 8.


PMID- 23183597
OWN - NLM
STAT- MEDLINE
DCOM- 20130509
LR  - 20121127
IS  - 1708-8283 (Electronic)
IS  - 0883-0738 (Linking)
VI  - 27
IP  - 12
DP  - 2012 Dec
TI  - "3 . . 2 . . 1 . . Impact [factor]: target [academic career] destroyed!": just
      another statistical casualty.
PG  - 1565-76
LID - 10.1177/0883073812465014 [doi]
AB  - "Publish or perish" is the time-honored "principle" for academicians who race to 
      accumulate lines under the "publications" section of a curriculum vitae. The
      original intent of publication-to inform others of findings and further
      scientific knowledge-has been corrupted by factors including (1) exponential
      growth of journals and the journal industry, fueled in part by intrusion of the
      Internet into all aspects of academic life; and (2) adoption of journal metrics
      (rather than written content) as the measure of scientific quality. The
      proprietary Thomson Reuters Impact Factor is the most pernicious metric, having
      caused editors and publishers to change editorial practices to boost the number. 
      At the same time, gullible administrators and government agencies have been
      persuaded that metrics for the journal in which materials are published can be
      used as a measure of the worth of individual investigators (and institutions) and
      their research efforts: simple numbers can be substituted for the burdensome
      effort required to read and assess research quality. Thus, granting of research
      funds, awarding of academic rank and tenure, and determination of salaries
      (including bonus payments) have become tied to manipulable journal metrics rather
      than the significance or quality of reported research. Therefore, it is no wonder
      that the integrity of science is more often being questioned. How should a young 
      investigator approach the "publish or perish" dilemma? Performing sound research 
      and preparing optimal materials for publication must remain the overriding goals:
      properly articulate the question addressed by the study; thoroughly document all 
      methods and case information; carefully describe results including any
      conflicting or negative findings; discuss the importance of the findings along
      with how the results address the initial question and whether findings refute or 
      confirm previous studies; prepare properly cited bibliographic references; list
      all author contributions, potential conflicts of interest, financial support, and
      required ethical approvals; and provide a catchy title and an abstract containing
      sufficient information that other investigators perusing scientific indices will 
      be enticed to read the published article. Submit the completed manuscript to the 
      most appropriate journal based on that journal's previously published content and
      relevance to the field of study regardless of journal metrics. On publication,
      notify investigators in the same field to ask for their comments on the work.
      Thus, an individual will become known for the quality of his or her work product 
      and the worshiping of publication metrics will be unnecessary.
FAU - Brumback, Roger A
AU  - Brumback RA
AD  - Creighton University School of Medicine, Omaha, NE 68131, USA.
      rogerbrumback@hotmail.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Child Neurol
JT  - Journal of child neurology
JID - 8606714
SB  - IM
MH  - *Bibliometrics
MH  - *Databases, Bibliographic/statistics & numerical data
MH  - Humans
MH  - *Journal Impact Factor
MH  - Neurology/*statistics & numerical data
MH  - Retrospective Studies
EDAT- 2012/11/28 06:00
MHDA- 2013/05/10 06:00
CRDT- 2012/11/28 06:00
PHST- 2012/11/28 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/05/10 06:00 [medline]
AID - 27/12/1565 [pii]
AID - 10.1177/0883073812465014 [doi]
PST - ppublish
SO  - J Child Neurol. 2012 Dec;27(12):1565-76. doi: 10.1177/0883073812465014.


PMID- 23183540
OWN - NLM
STAT- MEDLINE
DCOM- 20140204
LR  - 20130715
IS  - 1876-4347 (Electronic)
IS  - 1871-6784 (Linking)
VI  - 30
IP  - 5
DP  - 2013 Jun 25
TI  - The SNPs in the human genetic blueprint era.
PG  - 475-84
LID - 10.1016/j.nbt.2012.11.015 [doi]
LID - S1871-6784(12)00872-2 [pii]
AB  - The analysis of human genetic variability can lead to the comprehension of
      medical issues and to the development of personalized therapeutic protocols.
      Single nucleotide polymorphisms, are the most common type of human genetic
      variation and have been associated to disease development and phenotype
      forecasting. The recent technologies for DNA sequencing and bioinformatic
      analysis are now giving the opportunity to develop new diagnostic and prevention 
      approaches also through health promotion protocols. The genetic data management
      is at the same time underlining technical limitations and old ethical issues.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Giampaoli, S
AU  - Giampaoli S
AD  - University of Rome "Foro Italico", Italy.
FAU - Chillemi, G
AU  - Chillemi G
FAU - Valeriani, F
AU  - Valeriani F
FAU - Lazzaro, D
AU  - Lazzaro D
FAU - Borro, M
AU  - Borro M
FAU - Gentile, G
AU  - Gentile G
FAU - Simmaco, M
AU  - Simmaco M
FAU - Zanni, G
AU  - Zanni G
FAU - Berti, A
AU  - Berti A
FAU - Romano Spica, V
AU  - Romano Spica V
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121124
PL  - Netherlands
TA  - N Biotechnol
JT  - New biotechnology
JID - 101465345
SB  - IM
MH  - *Bioethical Issues
MH  - Genetics, Medical/*methods/*trends
MH  - Humans
MH  - *Phenotype
MH  - *Polymorphism, Single Nucleotide
MH  - *Sequence Analysis, DNA
EDAT- 2012/11/28 06:00
MHDA- 2014/02/05 06:00
CRDT- 2012/11/28 06:00
PHST- 2012/09/27 00:00 [received]
PHST- 2012/11/07 00:00 [revised]
PHST- 2012/11/15 00:00 [accepted]
PHST- 2012/11/28 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2014/02/05 06:00 [medline]
AID - S1871-6784(12)00872-2 [pii]
AID - 10.1016/j.nbt.2012.11.015 [doi]
PST - ppublish
SO  - N Biotechnol. 2013 Jun 25;30(5):475-84. doi: 10.1016/j.nbt.2012.11.015. Epub 2012
      Nov 24.


PMID- 23182956
OWN - NLM
STAT- MEDLINE
DCOM- 20130610
LR  - 20130107
IS  - 1532-3102 (Electronic)
IS  - 0143-4004 (Linking)
VI  - 34
IP  - 1
DP  - 2013 Jan
TI  - Review: Public perspectives on the utilization of human placentas in scientific
      research and medicine.
PG  - 9-13
LID - 10.1016/j.placenta.2012.10.014 [doi]
LID - S0143-4004(12)00407-9 [pii]
AB  - Placental tissues are frequently utilized by scientists studying pregnancy and
      reproduction and in diverse fields including immunology, stem cell research,
      genetics, cancer research, and tissue engineering, as well as by clinicians in
      many therapies. Though the utilization of the human placenta in science and
      medicine has benefitted many people, little is known about public perspectives of
      this phenomenon. This review addresses placental donation, collection, and
      utilization in science and medicine, focusing on public perspectives. Cultural
      values and traditions, ethical paradigms and concerns, public understandings of
      science and medicine, and political considerations may impact perceptions of the 
      utilization of the placenta in science and medicine, but systematic study is
      lacking. It is argued that knowledge of public views gained from empirical
      investigation may underpin the development of collection protocols and research
      projects that are more responsive to public will, spur more extensive utilization
      in science and medicine of this unique organ, and/or aid in the realization of
      the mobilization of knowledge about the placenta for clinical and educational
      ends. New avenues for research on public perspectives of the placenta are
      proposed.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Yoshizawa, R S
AU  - Yoshizawa RS
AD  - Centre for Research on Reproductive Health of Campinas (CEMICAMP), University of 
      Campinas, Campinas, Sao Paulo, Brazil. rebeccayoshizawa@gmail.com
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20121124
PL  - Netherlands
TA  - Placenta
JT  - Placenta
JID - 8006349
SB  - IM
MH  - Biomedical Research/ethics/*methods
MH  - Female
MH  - Humans
MH  - Medicine/methods
MH  - Perception/physiology
MH  - Placenta/*cytology
MH  - Pregnancy
MH  - *Public Opinion
MH  - Science/ethics/methods
MH  - Tissue and Organ Procurement/ethics/methods
EDAT- 2012/11/28 06:00
MHDA- 2013/06/12 06:00
CRDT- 2012/11/28 06:00
PHST- 2012/06/14 00:00 [received]
PHST- 2012/09/25 00:00 [revised]
PHST- 2012/10/26 00:00 [accepted]
PHST- 2012/11/28 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/06/12 06:00 [medline]
AID - S0143-4004(12)00407-9 [pii]
AID - 10.1016/j.placenta.2012.10.014 [doi]
PST - ppublish
SO  - Placenta. 2013 Jan;34(1):9-13. doi: 10.1016/j.placenta.2012.10.014. Epub 2012 Nov
      24.


PMID- 23182850
OWN - NLM
STAT- MEDLINE
DCOM- 20130826
LR  - 20151119
IS  - 1878-7886 (Electronic)
IS  - 1878-7886 (Linking)
VI  - 150
IP  - 1
DP  - 2013 Feb
TI  - Hyperthermic isolated liver perfusion with melphalan and bevacizumab.
PG  - 60-6
LID - 10.1016/j.jviscsurg.2012.10.018 [doi]
LID - S1878-7886(12)00119-1 [pii]
AB  - Whereas surgical resection is the only curative treatment for liver tumors,
      effective treatment for isolated unresectable lesions when there is tumor
      progression in spite of several lines of chemotherapy remains to be found. We
      report herein two cases of patients treated by a 1-hour Hyperthermic Isolated
      Liver Perfusion (HILP) with a combination of melphalan and bevacizumab leading to
      complete response. The first patient had liver metastases secondary to previously
      resected malignant glucagonoma and the second, recurrent hepatocellular
      carcinoma. We used bevacizumab in association with melphalan for HILP because of 
      the additional effect of an anti-VEGF antibody in these highly vascularized
      tumors and its locally restricted delivery to the isolated hepatic vascular
      compartment despite of its classic contraindication in association with surgery. 
      The protocol was approved by the Ethics Committee. Enhanced CT scans during
      follow-up showed complete tumor necrosis as early as the second postoperative
      day. Patients had 27 and 7 months disease-free survival and 48 and 41 months
      overall survival after HILP, for neuroendocrine liver metastases and HILP plus
      liver transplantation for HCC respectively. Under very specific conditions,
      bevacizumab in HILP can provide excellent tumor response in hopeless clinical
      cases of liver tumors.
CI  - Copyright (c) 2012 Elsevier Masson SAS. All rights reserved.
FAU - Voron, T
AU  - Voron T
AD  - Service de chirurgie generale, digestive et oncologique, Inserm CIE4, hopital
      Europeen Georges-Pompidou, AP-HP, 20, rue Leblanc, 75015 Paris, France.
FAU - Zinzindohoue, F
AU  - Zinzindohoue F
FAU - Journois, D
AU  - Journois D
FAU - Herve, C
AU  - Herve C
FAU - Ponzio, O
AU  - Ponzio O
FAU - Lucas, N
AU  - Lucas N
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20121123
PL  - France
TA  - J Visc Surg
JT  - Journal of visceral surgery
JID - 101532664
RN  - 0 (Antibodies, Monoclonal, Humanized)
RN  - 0 (Antineoplastic Agents)
RN  - 2S9ZZM9Q9V (Bevacizumab)
RN  - Q41OR9510P (Melphalan)
SB  - IM
MH  - Adult
MH  - Antibodies, Monoclonal, Humanized/administration & dosage
MH  - Antineoplastic Agents/administration & dosage
MH  - Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
MH  - Bevacizumab
MH  - Carcinoma, Hepatocellular/therapy
MH  - Chemotherapy, Cancer, Regional Perfusion/*methods
MH  - Combined Modality Therapy
MH  - Fatal Outcome
MH  - Female
MH  - Glucagonoma/secondary/therapy
MH  - Humans
MH  - *Hyperthermia, Induced
MH  - Liver Neoplasms/secondary/*therapy
MH  - Male
MH  - Melphalan/administration & dosage
MH  - Middle Aged
MH  - Pancreatic Neoplasms/pathology
EDAT- 2012/11/28 06:00
MHDA- 2013/08/27 06:00
CRDT- 2012/11/28 06:00
PHST- 2012/11/28 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/08/27 06:00 [medline]
AID - S1878-7886(12)00119-1 [pii]
AID - 10.1016/j.jviscsurg.2012.10.018 [doi]
PST - ppublish
SO  - J Visc Surg. 2013 Feb;150(1):60-6. doi: 10.1016/j.jviscsurg.2012.10.018. Epub
      2012 Nov 23.


PMID- 23182182
OWN - NLM
STAT- MEDLINE
DCOM- 20130517
LR  - 20151119
IS  - 1769-6623 (Electronic)
IS  - 0750-7658 (Linking)
VI  - 31
IP  - 12
DP  - 2012 Dec
TI  - [Epidemiology and evaluation of withdrawing and withholding of treatment
      procedure in a pediatric intensive care unit].
PG  - 937-44
LID - 10.1016/j.annfar.2012.09.010 [doi]
LID - S0750-7658(12)00400-5 [pii]
AB  - OBJECTIVES: Leonetti Law of 2005 concerns procedures for questioning about the
      appropriateness of initiating or maintaining life-sustaining treatments. Decision
      of withdrawing and withholding treatment has long been practiced by
      neonatologists, adult and pediatricians intensivists. In this regard, the
      recommendations of societies encourage medical teams to assess their practices to
      improve them. Our evaluation is based on the document of the Ethics Committee of 
      SRLF edited in 2010. TYPE OF STUDY: We achieved a retrospective evaluation of
      professional practices of the transcription of our decisions of withdrawing and
      withholding treatment. PATIENTS AND METHODS: This study included all children (95
      patients) who have had a questioning about life-sustaining treatment of ICU
      between March 2008 and August 2011 in the pediatric intensive care unit of
      Children's Hospital of Lyon. Our evaluation is based on the document of the
      Ethics Committee of French Society of intensive care (SRLF) edited in 2010. We
      collected epidemiological data on children concerned by questioning about the
      appropriateness of initiating or maintaining LST and an evaluation of the
      transcription of our procedures for LST in our folders. Evaluation included 40
      cases: 20 folders randomly selected prior an information meeting (January 2011)
      which were compared with 20 cases occurred consecutively after this information. 
      This meeting was intended to remind recommendations of good practice and
      principal points of the law. The main assessment measure was the improvement of
      the practices respecting criteria of the document of the Ethics Committee of SRLF
      modified for pediatric care. MAIN RESULTS: Epidemiological data on procedures are
      comparable to literature data. Concerning the evaluation of our practices
      before/after a briefing and highlighted a tendency to the improvement without
      statistically significance. The transcription of reflection and the arguments of 
      decision of withdrawing and withholding treatment and evaluation of pain was the 
      points who need improvement. Finally, despite the positive developments in the
      therapeutic use of analgesics and sedatives, pain continues to be undervalued.
      CONCLUSION: The evaluation of professional practices is recommended to improve
      the procedures of questioning about life-sustaining treatments have become an
      area of expertise in intensive care.
CI  - Copyright (c) 2012. Published by Elsevier SAS.
FAU - Bordet, F
AU  - Bordet F
AD  - Service de reanimation pediatrique, hopital Femme-Mere-Enfant, 59 boulevard
      Pinel, Lyon-Bron, France. fabienne.bordet@chu-lyon.fr
FAU - Bouvier-Jambon, G
AU  - Bouvier-Jambon G
FAU - Didier, C
AU  - Didier C
FAU - Javouhey, E
AU  - Javouhey E
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Epidemiologie et evaluation des procedures de limitation et d'arret des
      traitements de maintien des fonctions vitales en reanimation pediatrique.
DEP - 20121120
PL  - France
TA  - Ann Fr Anesth Reanim
JT  - Annales francaises d'anesthesie et de reanimation
JID - 8213275
RN  - 0 (Analgesics)
RN  - 0 (Hypnotics and Sedatives)
SB  - IM
MH  - Analgesics/therapeutic use
MH  - Child
MH  - Child, Preschool
MH  - Critical Care/statistics & numerical data
MH  - Drug Utilization
MH  - Ethics Committees, Clinical
MH  - Female
MH  - Hospital Mortality
MH  - Humans
MH  - Hypnotics and Sedatives/therapeutic use
MH  - Infant
MH  - Intensive Care Units, Pediatric/ethics/legislation & jurisprudence/*statistics & 
      numerical data
MH  - Length of Stay
MH  - Life Support Care/statistics & numerical data
MH  - Male
MH  - Pain Measurement
MH  - Parents
MH  - Resuscitation Orders
MH  - Retrospective Studies
MH  - Withholding Treatment/ethics/legislation & jurisprudence/*statistics & numerical 
      data
EDAT- 2012/11/28 06:00
MHDA- 2013/05/18 06:00
CRDT- 2012/11/28 06:00
PHST- 2012/05/06 00:00 [received]
PHST- 2012/09/18 00:00 [accepted]
PHST- 2012/11/28 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/05/18 06:00 [medline]
AID - S0750-7658(12)00400-5 [pii]
AID - 10.1016/j.annfar.2012.09.010 [doi]
PST - ppublish
SO  - Ann Fr Anesth Reanim. 2012 Dec;31(12):937-44. doi: 10.1016/j.annfar.2012.09.010. 
      Epub 2012 Nov 20.


PMID- 23181930
OWN - NLM
STAT- MEDLINE
DCOM- 20140826
LR  - 20131114
IS  - 1440-1800 (Electronic)
IS  - 1320-7881 (Linking)
VI  - 20
IP  - 4
DP  - 2013 Dec
TI  - The meaningful encounter: patient and next-of-kin stories about their experience 
      of meaningful encounters in health-care.
PG  - 363-71
LID - 10.1111/nin.12013 [doi]
AB  - This study focuses on the meaningful encounters of patients and next of kin, as
      seen from their perspective. Identifying the attributes within meaningful
      encounters is important for increased understanding of caring and to expand and
      develop earlier formulated knowledge about caring relationships. Caring theory
      about the caring relationship provided a point of departure to illuminate the
      meaningful encounter in healthcare contexts. A qualitative explorative design
      with a hermeneutic narrative approach was used to analyze and interpret written
      narratives. The phases of the analysis were naive interpretation, structure
      analysis on two different levels (narrative structure, and deep structure through
      metaphors) and finally a dialectic interpretation. The narratives revealed the
      meaning of the meaningful encounter as sharing, a nourishing fellowship, common
      responsibility and coming together, experienced as safety and warmth, that gives,
      by extension, life-changing moments, a healing force and dissipated insight. The 
      meaningful encounter can be seen as a complex phenomenon with various attributes.
      Understanding the meaningful encounter will enable nurses to plan and provide
      professional care, based on caring science, focusing on patient and next-of-kin
      experiences.
CI  - (c) 2013 John Wiley & Sons Ltd.
FAU - Gustafsson, Lena-Karin
AU  - Gustafsson LK
AD  - School of Health, Care and Social Welfare, Malardalen University, Sweden.
FAU - Snellma, Ingrid
AU  - Snellma I
FAU - Gustafsson, Christine
AU  - Gustafsson C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121127
PL  - Australia
TA  - Nurs Inq
JT  - Nursing inquiry
JID - 9505881
MH  - Attitude of Health Personnel
MH  - *Attitude to Health
MH  - Female
MH  - Humans
MH  - Male
MH  - Narration
MH  - *Nurse-Patient Relations
MH  - *Nursing Theory
MH  - *Professional-Family Relations
MH  - Sweden
OTO - NOTNLM
OT  - caring
OT  - encounters
OT  - ethics
OT  - healthcare
OT  - hermeneutic
OT  - narrative analysis
EDAT- 2012/11/28 06:00
MHDA- 2014/08/27 06:00
CRDT- 2012/11/28 06:00
PHST- 2012/11/28 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2014/08/27 06:00 [medline]
AID - 10.1111/nin.12013 [doi]
PST - ppublish
SO  - Nurs Inq. 2013 Dec;20(4):363-71. doi: 10.1111/nin.12013. Epub 2012 Nov 27.


PMID- 23181832
OWN - NLM
STAT- MEDLINE
DCOM- 20130516
LR  - 20211021
IS  - 1471-2431 (Electronic)
IS  - 1471-2431 (Linking)
VI  - 12
DP  - 2012 Nov 26
TI  - Oral cleft prevention program (OCPP).
PG  - 184
LID - 10.1186/1471-2431-12-184 [doi]
AB  - BACKGROUND: Oral clefts are one of the most common birth defects with significant
      medical, psychosocial, and economic ramifications. Oral clefts have a complex
      etiology with genetic and environmental risk factors. There are suggestive
      results for decreased risks of cleft occurrence and recurrence with folic acid
      supplements taken at preconception and during pregnancy with a stronger evidence 
      for higher than lower doses in preventing recurrence. Yet previous studies have
      suffered from considerable design limitations particularly non-randomization into
      treatment. There is also well-documented effectiveness for folic acid in
      preventing neural tube defect occurrence at 0.4 mg and recurrence with 4 mg.
      Given the substantial burden of clefting on the individual and the family and the
      supportive data for the effectiveness of folic acid supplementation as well as
      its low cost, a randomized clinical trial of the effectiveness of high versus low
      dose folic acid for prevention of cleft recurrence is warranted. METHODS/DESIGN: 
      This study will assess the effect of 4 mg and 0.4 mg doses of folic acid, taken
      on a daily basis during preconception and up to 3 months of pregnancy by women
      who are at risk of having a child with nonsyndromic cleft lip with/without palate
      (NSCL/P), on the recurrence of NSCL/P. The total sample will include about 6,000 
      women (that either have NSCL/P or that have at least one child with NSCL/P)
      randomly assigned to the 4 mg and the 0.4 mg folic acid study groups. The study
      will also compare the recurrence rates of NSCL/P in the total sample of subjects,
      as well as the two study groups (4 mg, 0.4 mg) to that of a historical control
      group. The study has been approved by IRBs (ethics committees) of all involved
      sites. Results will be disseminated through publications and presentations at
      scientific meetings. DISCUSSION: The costs related to oral clefts are high,
      including long term psychological and socio-economic effects. This study provides
      an opportunity for huge savings in not only money but the overall quality of
      life. This may help establish more specific clinical guidelines for oral cleft
      prevention so that the intervention can be better tailored for at-risk women.
      CLINICALTRIALS.GOV IDENTIFIER: NCT00397917.
FAU - Wehby, George L
AU  - Wehby GL
AD  - University of Iowa, Iowa City, IA, USA.
FAU - Goco, Norman
AU  - Goco N
FAU - Moretti-Ferreira, Danilo
AU  - Moretti-Ferreira D
FAU - Felix, Temis
AU  - Felix T
FAU - Richieri-Costa, Antonio
AU  - Richieri-Costa A
FAU - Padovani, Carla
AU  - Padovani C
FAU - Queiros, Fernanda
AU  - Queiros F
FAU - Guimaraes, Camilla Vila Nova
AU  - Guimaraes CV
FAU - Pereira, Rui
AU  - Pereira R
FAU - Litavecz, Steve
AU  - Litavecz S
FAU - Hartwell, Tyler
AU  - Hartwell T
FAU - Chakraborty, Hrishikesh
AU  - Chakraborty H
FAU - Javois, Lorette
AU  - Javois L
FAU - Murray, Jeffrey C
AU  - Murray JC
LA  - eng
SI  - ClinicalTrials.gov/NCT00397917
GR  - R01 DE008559/DE/NIDCR NIH HHS/United States
GR  - R37 DE008559/DE/NIDCR NIH HHS/United States
GR  - U01 DE017958/DE/NIDCR NIH HHS/United States
GR  - U01HD040561/HD/NICHD NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
DEP - 20121126
PL  - England
TA  - BMC Pediatr
JT  - BMC pediatrics
JID - 100967804
RN  - 12001-76-2 (Vitamin B Complex)
RN  - 935E97BOY8 (Folic Acid)
SB  - IM
MH  - Cleft Lip/*prevention & control
MH  - Cleft Palate/*prevention & control
MH  - Clinical Protocols
MH  - *Dietary Supplements
MH  - Dose-Response Relationship, Drug
MH  - Double-Blind Method
MH  - Drug Administration Schedule
MH  - Female
MH  - Folic Acid/*therapeutic use
MH  - Follow-Up Studies
MH  - Humans
MH  - Infant, Newborn
MH  - Pilot Projects
MH  - Preconception Care/*methods
MH  - Pregnancy
MH  - Prenatal Care/*methods
MH  - Research Design
MH  - Secondary Prevention
MH  - Vitamin B Complex/*therapeutic use
PMC - PMC3532199
EDAT- 2012/11/28 06:00
MHDA- 2013/05/17 06:00
CRDT- 2012/11/28 06:00
PHST- 2012/10/05 00:00 [received]
PHST- 2012/11/13 00:00 [accepted]
PHST- 2012/11/28 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/05/17 06:00 [medline]
AID - 1471-2431-12-184 [pii]
AID - 10.1186/1471-2431-12-184 [doi]
PST - epublish
SO  - BMC Pediatr. 2012 Nov 26;12:184. doi: 10.1186/1471-2431-12-184.


PMID- 23181778
OWN - NLM
STAT- MEDLINE
DCOM- 20140702
LR  - 20211021
IS  - 1471-2458 (Electronic)
IS  - 1471-2458 (Linking)
VI  - 12
DP  - 2012 Nov 22
TI  - The LIFE child study: a life course approach to disease and health.
PG  - 1021
LID - 10.1186/1471-2458-12-1021 [doi]
AB  - BACKGROUND: Profound knowledge about child growth, development, health, and
      disease in contemporary children and adolescents is still rare. Epidemiological
      studies together with new powerful research technologies present exciting
      opportunities to the elucidation of risk factor-outcome associations with
      potentially major consequences for prevention, diagnosis and treatment. AIM: To
      conduct a unique prospective longitudinal cohort study in order to assess how
      environmental, metabolic and genetic factors affect growth, development and
      health from fetal life to adulthood. METHODS: The 'Leipzig Research Centre for
      Civilization Diseases (LIFE) Child Study' focuses on two main research
      objectives: (1) monitoring of normal growth, development and health; (2)
      non-communicable diseases such as childhood obesity and its co-morbidities, atopy
      and mental health problems. Detailed assessments will be conducted alongside
      long-term storage of biological samples in 2,000 pregnant women and more than
      10,000 children and their families. RESULTS: Close coordination and engagement of
      a multidisciplinary team in the LIFE Child study successfully established
      procedures and systems for balancing many competing study and ethical needs. Full
      participant recruitment and complete data collection started in July 2011. Early 
      data indicate a high acceptance rate of the study program, successful recruitment
      strategies and the establishment of a representative cohort for the population of
      Leipzig. A series of subprojects are ongoing, and analyses and publications are
      on their way. DISCUSSION: This paper addresses key elements in the design and
      implementation of the new prospective longitudinal cohort study LIFE Child. Given
      the recognized need for long-term data on adverse effects on health and
      protective factors, our study data collection should provide magnificent
      opportunities to examine complex interactions that govern the emergence of
      non-communicable diseases.
FAU - Quante, Mirja
AU  - Quante M
AD  - LIFE Leipzig Research Centre for Civilization Diseases, University of Leipzig,
      Philipp-Rosenthalstrasse 27, D-04103 Leipzig, Germany.
      contact@life.uni-leipzig.de
FAU - Hesse, Mara
AU  - Hesse M
FAU - Dohnert, Mirko
AU  - Dohnert M
FAU - Fuchs, Michael
AU  - Fuchs M
FAU - Hirsch, Christian
AU  - Hirsch C
FAU - Sergeyev, Elena
AU  - Sergeyev E
FAU - Casprzig, Nora
AU  - Casprzig N
FAU - Geserick, Mandy
AU  - Geserick M
FAU - Naumann, Stephanie
AU  - Naumann S
FAU - Koch, Christiane
AU  - Koch C
FAU - Sabin, Matthew A
AU  - Sabin MA
FAU - Hiemisch, Andreas
AU  - Hiemisch A
FAU - Korner, Antje
AU  - Korner A
FAU - Kiess, Wieland
AU  - Kiess W
CN  - LIFE Child Study Investigators
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121122
PL  - England
TA  - BMC Public Health
JT  - BMC public health
JID - 100968562
SB  - IM
MH  - Adolescent
MH  - Cohort Studies
MH  - Female
MH  - Growth and Development/*physiology
MH  - Health Promotion/*methods
MH  - Humans
MH  - Infant
MH  - Male
MH  - Pregnancy
MH  - Prospective Studies
MH  - *Quality of Life
MH  - *Urban Population
MH  - Young Adult
PMC - PMC3533937
EDAT- 2012/11/28 06:00
MHDA- 2014/07/06 06:00
CRDT- 2012/11/28 06:00
PHST- 2012/10/03 00:00 [received]
PHST- 2012/11/12 00:00 [accepted]
PHST- 2012/11/28 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2014/07/06 06:00 [medline]
AID - 1471-2458-12-1021 [pii]
AID - 10.1186/1471-2458-12-1021 [doi]
PST - epublish
SO  - BMC Public Health. 2012 Nov 22;12:1021. doi: 10.1186/1471-2458-12-1021.


PMID- 23181608
OWN - NLM
STAT- MEDLINE
DCOM- 20130903
LR  - 20211021
IS  - 1744-1706 (Electronic)
IS  - 1744-1692 (Linking)
VI  - 8
IP  - 3
DP  - 2013
TI  - HIV testing for pregnant women: a rights-based analysis of national policies.
PG  - 326-41
LID - 10.1080/17441692.2012.745010 [doi]
AB  - Ethical and human rights concerns have been expressed regarding the global shift 
      in policies on HIV testing of pregnant women. The main purpose of this research
      was to conduct a policy analysis using a human rights-based approach of national 
      policies for HIV testing of pregnant women. We collected HIV testing policies
      from 19 countries including: Cambodia, China, Guyana, Haiti, India, Jamaica,
      Kenya, Moldova, Papua New Guinea, Russian Federation, South Africa, Sudan,
      Swaziland, Tanzania, Ukraine, United States, Uzbekistan, Zambia and Zimbabwe. We 
      analysed the HIV testing policies using a standardised framework that focused on 
      government obligations to respect, protect and fulfil. Our results highlight the 
      need for more attention to issues of pregnant women's autonomy in consenting to
      HIV testing, confidentiality in antenatal care settings and provision of
      counselling and care services. We conclude with a discussion about potential
      implications of the current testing policies and provide recommendations for ways
      that HIV testing policies can more effectively uphold the human rights of
      pregnant women.
FAU - King, Elizabeth J
AU  - King EJ
AD  - Yale University School of Public Health, New Haven, CT, USA.
      elizabeth.king@yale.edu
FAU - Maman, Suzanne
AU  - Maman S
FAU - Wyckoff, Sarah C
AU  - Wyckoff SC
FAU - Pierce, Matthew W
AU  - Pierce MW
FAU - Groves, Allison K
AU  - Groves AK
LA  - eng
GR  - T32 AI007001/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121126
PL  - England
TA  - Glob Public Health
JT  - Global public health
JID - 101256323
SB  - IM
MH  - Confidentiality
MH  - Developed Countries
MH  - Developing Countries
MH  - Female
MH  - HIV Seropositivity/*diagnosis/epidemiology
MH  - *Health Policy
MH  - Health Services Accessibility
MH  - Human Rights/*legislation & jurisprudence
MH  - Humans
MH  - Informed Consent
MH  - Mass Screening/*legislation & jurisprudence
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/*diagnosis/epidemiology
PMC - PMC4374436
MID - NIHMS672630
EDAT- 2012/11/28 06:00
MHDA- 2013/09/04 06:00
CRDT- 2012/11/28 06:00
PHST- 2012/11/28 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/09/04 06:00 [medline]
AID - 10.1080/17441692.2012.745010 [doi]
PST - ppublish
SO  - Glob Public Health. 2013;8(3):326-41. doi: 10.1080/17441692.2012.745010. Epub
      2012 Nov 26.


PMID- 23181495
OWN - NLM
STAT- MEDLINE
DCOM- 20130502
LR  - 20181202
IS  - 1741-4520 (Electronic)
IS  - 0914-3505 (Linking)
VI  - 52
IP  - 4
DP  - 2012 Dec
TI  - Prenatal diagnosis of osteogenesis imperfecta type II by three-dimensional
      computed tomography: the current state of fetal computed tomography.
PG  - 203-6
LID - 10.1111/j.1741-4520.2011.00346.x [doi]
AB  - We report a case of osteogenesis imperfecta (OI) (OMIM166210) type II, in which a
      prenatal diagnosis was made by three-dimensional computed tomography (3D-CT).
      Subsequent molecular analysis revealed a recurrent, heterozygous mutation in
      COL1A2. Fetal CT is a powerful tool for visualizing the fetal skeleton and can
      provide a definitive diagnosis of fetal skeletal dysplasias; however, whether or 
      not its employment for prenatal diagnosis is warranted in terms of fetal
      radiation risks remains controversial, both medically and ethically. Based on our
      experience, we review the current state of fetal CT for the diagnosis of skeletal
      dysplasias, with a discussion of the relevant literature.
CI  - (c) 2011 The Authors. Congenital Anomalies (c) 2011 Japanese Teratology Society.
FAU - Akizawa, Yoshika
AU  - Akizawa Y
AD  - Institute of Medical Genetics Department of Obstetrics and Gynecology, Tokyo
      Women's Medical University, Tokyo, Japan.
FAU - Nishimura, Gen
AU  - Nishimura G
FAU - Hasegawa, Tomonobu
AU  - Hasegawa T
FAU - Takagi, Masaki
AU  - Takagi M
FAU - Kawamichi, Yayoi
AU  - Kawamichi Y
FAU - Matsuda, Yoshio
AU  - Matsuda Y
FAU - Matsui, Hideo
AU  - Matsui H
FAU - Saito, Kayoko
AU  - Saito K
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Australia
TA  - Congenit Anom (Kyoto)
JT  - Congenital anomalies
JID - 9306292
RN  - 0 (Collagen Type I)
SB  - IM
MH  - Abortion, Induced
MH  - Adult
MH  - Collagen Type I/genetics
MH  - Female
MH  - *Four-Dimensional Computed Tomography
MH  - Humans
MH  - Mutation
MH  - Osteogenesis Imperfecta/*diagnostic imaging/genetics
MH  - Pregnancy
MH  - *Prenatal Diagnosis
MH  - Ultrasonography
EDAT- 2012/11/28 06:00
MHDA- 2013/05/03 06:00
CRDT- 2012/11/28 06:00
PHST- 2012/11/28 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/05/03 06:00 [medline]
AID - 10.1111/j.1741-4520.2011.00346.x [doi]
PST - ppublish
SO  - Congenit Anom (Kyoto). 2012 Dec;52(4):203-6. doi:
      10.1111/j.1741-4520.2011.00346.x.


PMID- 23181453
OWN - NLM
STAT- MEDLINE
DCOM- 20130522
LR  - 20211021
IS  - 1471-2296 (Electronic)
IS  - 1471-2296 (Linking)
VI  - 13
DP  - 2012 Nov 26
TI  - Setting priorities in primary health care--on whose conditions? A questionnaire
      study.
PG  - 114
LID - 10.1186/1471-2296-13-114 [doi]
AB  - BACKGROUND: In Sweden three key criteria are used for priority setting: severity 
      of the health condition; patient benefit; and cost-effectiveness. They are
      derived from the ethical principles established by the Swedish parliament 1997
      but have been used only to a limited extent in primary care. The aim of this
      study was to describe and analyse: 1) GPs', nurses', and patients' prioritising
      in routine primary care 2) The association between the three key priority setting
      criteria and the overall priority assigned by the GPs and nurses to individual
      patients. METHODS: Paired questionnaires were distributed to all patients and the
      GPs or nurses they had contact with during a 2-week period at four health centres
      in Sweden. The staff registered the health conditions or health problem, and the 
      planned intervention. Then they estimated the severity of the health condition,
      the expected patient benefit, and the cost-effectiveness of the planned
      intervention. Both the staff and the patients reported their overall
      prioritisation of the patient. In total, 1851 paired questionnaires were
      collected. RESULTS: Compared to the medical staff, the patients assigned
      relatively higher priority to acute/minor conditions than to preventive check-ups
      for chronic conditions. Severity of the health condition was the priority setting
      criterion that had the strongest association with the overall priority for the
      staff as a whole, but for the GPs it was cost-effectiveness. CONCLUSIONS: The
      challenge for primary care providers is to balance the patients' demands with
      medical needs and cost-effectiveness. Transparent priority setting in primary
      care might contribute to a greater consensus between GPs and nurses on how to use
      the key priority setting criteria.
FAU - Arvidsson, Eva
AU  - Arvidsson E
AD  - Department of Medical and Health Sciences, National Centre for Priority Setting
      in Health Care, Linkoping University, Linkoping, Sweden.
      eva.arvidsson@ltkalmar.se
FAU - Andre, Malin
AU  - Andre M
FAU - Borgquist, Lars
AU  - Borgquist L
FAU - Andersson, David
AU  - Andersson D
FAU - Carlsson, Per
AU  - Carlsson P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121126
PL  - England
TA  - BMC Fam Pract
JT  - BMC family practice
JID - 100967792
SB  - IM
MH  - Acute Disease
MH  - Aged
MH  - Ambulatory Care
MH  - *Attitude of Health Personnel
MH  - *Attitude to Health
MH  - Chronic Disease
MH  - Cost-Benefit Analysis
MH  - Disease Management
MH  - Female
MH  - *Health Priorities
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Preventive Health Services
MH  - *Primary Health Care
MH  - Regression Analysis
MH  - Severity of Illness Index
MH  - *Surveys and Questionnaires
MH  - Sweden
PMC - PMC3528614
EDAT- 2012/11/28 06:00
MHDA- 2013/05/23 06:00
CRDT- 2012/11/28 06:00
PHST- 2012/05/17 00:00 [received]
PHST- 2012/11/15 00:00 [accepted]
PHST- 2012/11/28 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/05/23 06:00 [medline]
AID - 1471-2296-13-114 [pii]
AID - 10.1186/1471-2296-13-114 [doi]
PST - epublish
SO  - BMC Fam Pract. 2012 Nov 26;13:114. doi: 10.1186/1471-2296-13-114.


PMID- 23181399
OWN - NLM
STAT- MEDLINE
DCOM- 20130708
LR  - 20161020
IS  - 1552-6909 (Electronic)
IS  - 0090-0311 (Linking)
VI  - 42
IP  - 1
DP  - 2013 Jan-Feb
TI  - Clinician confidence and comfort in providing perinatal palliative care.
PG  - 48-58
LID - 10.1111/j.1552-6909.2012.01432.x [doi]
AB  - OBJECTIVE: To analyze and report the differences in perceptions of physicians and
      advance practice nurses, their comfort in providing and referring neonatal
      patients to perinatal palliative care (PPC), and their confidence in delivering
      such care. DESIGN: A cross-sectional survey design using the Perinatal Palliative
      Care Perceptions and Barriers Scale. SETTING: A survey was administered using
      Qualtrics, a Web-based tool. Recruitment was completed via e-mail invitation and 
      list servs. PARTICIPANTS: Physicians (n = 66), advance practice nurses (n = 146),
      and other clinicians (n = 90). METHODS: t test and Mann-Whitney U were used to
      examine differences in clinician perspectives, comfort, and confidence in
      delivering PPC. Hierarchical multiple regression was used to test the hypothesis 
      that clinician perceptions, barriers to PPC, years in clinician practice,
      referral comfort, and personal comfort and case history explain variation in
      confidence. RESULTS: Physicians and nurses have fundamentally similar
      perspectives but report significant differences in their comfort with providing
      and referring patients to PPC and their confidence in delivering such care. There
      was a significant regression equation with an overall R(2) of .56 explained
      variation in confidence. CONCLUSION: Palliative care involves physicians and
      nurses making unique and positively synergistic contributions to the care of
      families expecting an infant with a life-limiting diagnosis. Clinicians share
      ethical perspectives regarding PPC and are positioned to collaboratively develop 
      PPC programs. Barriers to PPC delivery exist and clinicians can benefit from
      interventions aimed at modifying practice environments. Supportive interventions 
      and educational initiatives may increase clinician comfort and confidence with
      palliative care delivery.
CI  - (c) 2012 AWHONN, the Association of Women's Health, Obstetric and Neonatal
      Nurses.
FAU - Wool, Charlotte
AU  - Wool C
AD  - York College of Pennsylvania, York, PA 17403, USA. cwool@ycp.edu
LA  - eng
PT  - Journal Article
DEP - 20121126
PL  - United States
TA  - J Obstet Gynecol Neonatal Nurs
JT  - Journal of obstetric, gynecologic, and neonatal nursing : JOGNN
JID - 8503123
SB  - IM
MH  - Congenital Abnormalities/*therapy
MH  - Cross-Sectional Studies
MH  - Female
MH  - Grief
MH  - Health Care Surveys
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - Multivariate Analysis
MH  - North America
MH  - Nurse Practitioners
MH  - *Palliative Care
MH  - *Practice Patterns, Nurses'
MH  - *Practice Patterns, Physicians'
MH  - *Professional-Family Relations/ethics
MH  - *Referral and Consultation
MH  - Self Efficacy
MH  - Social Support
EDAT- 2012/11/28 06:00
MHDA- 2013/07/09 06:00
CRDT- 2012/11/28 06:00
PHST- 2012/11/28 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/07/09 06:00 [medline]
AID - 10.1111/j.1552-6909.2012.01432.x [doi]
AID - S0884-2175(15)31243-0 [pii]
PST - ppublish
SO  - J Obstet Gynecol Neonatal Nurs. 2013 Jan-Feb;42(1):48-58. doi:
      10.1111/j.1552-6909.2012.01432.x. Epub 2012 Nov 26.


PMID- 23181211
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121128
LR  - 20211021
IS  - 2231-5004 (Electronic)
IS  - 2229-5151 (Linking)
VI  - 2
IP  - 3
DP  - 2012 Sep
TI  - Efficacy of Canadian computed tomography head rule in predicting the need for a
      computed-axial tomography scans among patients with suspected head injuries.
PG  - 163-6
LID - 10.4103/2229-5151.100904 [doi]
AB  - CONTEXT: The use of imaging modalities is crucial in the diagnostic field of
      critical medicine. However, the ethical and economic use of these techniques has 
      become a major concern especially in resource-poor settings. The Canadian
      computed tomography Head Rule (CCHR) is being increasingly used all over the
      world to evaluate the necessity of a Computer-assisted Tomography (CT) scan in
      patients with suspected head injury. AIM: The aim of the current study is to
      evaluate the efficacy of CCHR to predict the occurrence of head injury, as
      evidenced radiologically by a CT Head, at a government tertiary care clinical
      setting in south India. SETTING AND DESIGN: The design was that of a
      hospital-based cross-sectional survey conducted at the Medical College Hospital, 
      Thiruvananthapuram (Kerala, India). MATERIALS AND METHODS: The study subjects
      were patients with suspected head injury evaluated at the Surgical Casualty
      Department of the study setting. Fifty consecutive patients with suspected head
      injury were enrolled in the study. STATISTICAL ANALYSIS: The Chi-square test was 
      used to assess the statistical significance of association between the outcome
      variable and the exposure characteristics. The diagnostic ability of the Glasgow 
      Coma Scale (GCS) and CCHR were expressed in terms of sensitivity and specificity 
      by considering CT diagnosed Head injury as the gold standard diagnostic tool.
      RESULTS: Clinical manifestations as measured by a GCS score < 13 failed to
      significantly predict a head injury in the CT scan. However, the same became
      statistically significant when the CCHR was added to the GCS score as a predictor
      (P value < 0.001). The sensitivity of the tool in predicting a head injury rose
      from 23.3 to 96.7%. CONCLUSION: The current study suggested that the CCHR could
      act as an excellent decision rule to indicate the need of a CT scan. The need of 
      a decision rule was warranted in the context of the growth of newer diagnostic
      imaging facilities in India.
FAU - Anish, Thekkumkara Surendran Nair
AU  - Anish TS
AD  - Department of Community Medicine, Government Medical College, Thiruvananthapuram,
      Kerala, India.
FAU - Sreelakshmi, Pallipurathu Reghunathan Nair
AU  - Sreelakshmi PR
FAU - Medhavan, Sarath
AU  - Medhavan S
FAU - Babu, Shahid
AU  - Babu S
FAU - Sugathan, Sambu
AU  - Sugathan S
LA  - eng
PT  - Journal Article
PL  - India
TA  - Int J Crit Illn Inj Sci
JT  - International journal of critical illness and injury science
JID - 101571136
PMC - PMC3500009
OTO - NOTNLM
OT  - Canadian CT head rule
OT  - canadian CT head rule in India
OT  - canadian computed tomography Head Rule
OT  - computer-assisted tomography scan
OT  - head injury
EDAT- 2012/11/28 06:00
MHDA- 2012/11/28 06:01
CRDT- 2012/11/28 06:00
PHST- 2012/11/28 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2012/11/28 06:01 [medline]
AID - 10.4103/2229-5151.100904 [doi]
AID - IJCIIS-2-163 [pii]
PST - ppublish
SO  - Int J Crit Illn Inj Sci. 2012 Sep;2(3):163-6. doi: 10.4103/2229-5151.100904.


PMID- 23180985
OWN - NLM
STAT- MEDLINE
DCOM- 20130620
LR  - 20211021
IS  - 1935-469X (Electronic)
IS  - 1554-7477 (Linking)
VI  - 8
IP  - 4
DP  - 2012 Jul
TI  - Ethical challenges: caring for the underinsured, geographically disadvantaged
      patient.
PG  - 215-8
LID - 10.1200/JOP.2012.000603 [doi]
FAU - Riley, Elizabeth C
AU  - Riley EC
AD  - University of Louisville, Louisville, KY, USA.
FAU - Moy, Beverly
AU  - Moy B
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Oncol Pract
JT  - Journal of oncology practice
JID - 101261852
SB  - IM
MH  - Delivery of Health Care/*ethics
MH  - Healthcare Disparities/ethics
MH  - Humans
MH  - *Medically Uninsured
MH  - Vulnerable Populations
PMC - PMC3396816
EDAT- 2012/11/28 06:00
MHDA- 2013/06/21 06:00
CRDT- 2012/11/28 06:00
PHST- 2012/04/26 00:00 [accepted]
PHST- 2012/11/28 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/06/21 06:00 [medline]
AID - 10.1200/JOP.2012.000603 [doi]
AID - 3783511 [pii]
PST - ppublish
SO  - J Oncol Pract. 2012 Jul;8(4):215-8. doi: 10.1200/JOP.2012.000603.


PMID- 23180815
OWN - NLM
STAT- MEDLINE
DCOM- 20140127
LR  - 20220330
IS  - 1460-2229 (Electronic)
IS  - 0263-2136 (Linking)
VI  - 30
IP  - 3
DP  - 2013 Jun
TI  - Perceptions of preconception counselling among women planning a pregnancy: a
      qualitative study.
PG  - 341-6
LID - 10.1093/fampra/cms074 [doi]
AB  - BACKGROUND: Preconception care is a promising new approach to improve the health 
      of future children through primary intervention. Although most women have a
      positive attitude towards preconception care, women often do not seek
      preconception care for themselves. OBJECTIVE: To explore women's hesitancy to
      seek preconception counselling. METHODS: An empirical-analytic approach was used 
      to explore women's hesitation to seek preconception counselling. In-depth,
      semi-structured, face-to-face interviews (n = 16) of women desiring to conceive
      were conducted, and responses were analysed using the determinants 'attitude' and
      'subjective norms' of the Theory of Planned Behaviour of Ajzen. RESULTS: The
      interviewed women expressed a positive attitude towards preconception care in
      general but were hesitant about seeking preconception care themselves. Women
      seemed to regard themselves as not being in the target group for preconception
      care. Additionally, we identified the following four subthemes of subjective
      norms around the process of becoming pregnant: planning, publicity, information
      on fertility and artificiality. CONCLUSIONS: Women do not consider themselves to 
      be part of the target group for preconception care. In some aspects, subjective
      norms around the process of becoming pregnant may conflict with the current
      practice of preconception care. Recommendations are provided.
FAU - van der Zee, Boukje
AU  - van der Zee B
AD  - Department of Medical Ethics and Philosophy of Medicine, Erasmus University
      Medical Centre, Rotterdam, The Netherlands. boukjevanderzee@hotmail.com
FAU - de Beaufort, Inez D
AU  - de Beaufort ID
FAU - Steegers, Eric A P
AU  - Steegers EA
FAU - Denktas, Semiha
AU  - Denktas S
LA  - eng
PT  - Journal Article
DEP - 20121124
PL  - England
TA  - Fam Pract
JT  - Family practice
JID - 8500875
SB  - IM
MH  - Adult
MH  - Counseling/*statistics & numerical data
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Interviews as Topic
MH  - *Patient Acceptance of Health Care
MH  - Preconception Care/*statistics & numerical data
MH  - Pregnancy
MH  - Qualitative Research
OTO - NOTNLM
OT  - Medical ethics
OT  - Theory of Planned Behaviour.
OT  - preconception counselling
OT  - qualitative research
OT  - subjective norms
EDAT- 2012/11/28 06:00
MHDA- 2014/01/28 06:00
CRDT- 2012/11/28 06:00
PHST- 2012/11/28 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2014/01/28 06:00 [medline]
AID - cms074 [pii]
AID - 10.1093/fampra/cms074 [doi]
PST - ppublish
SO  - Fam Pract. 2013 Jun;30(3):341-6. doi: 10.1093/fampra/cms074. Epub 2012 Nov 24.


PMID- 23180585
OWN - NLM
STAT- MEDLINE
DCOM- 20140206
LR  - 20220330
IS  - 1399-3003 (Electronic)
IS  - 0903-1936 (Linking)
VI  - 42
IP  - 1
DP  - 2013 Jul
TI  - Rapid molecular TB diagnosis: evidence, policy making and global implementation
      of Xpert MTB/RIF.
PG  - 252-71
LID - 10.1183/09031936.00157212 [doi]
AB  - If tuberculosis (TB) is to be eliminated as a global health problem in the
      foreseeable future, improved detection of patients, earlier diagnosis and timely 
      identification of rifampicin resistance will be critical. New diagnostics
      released in recent years have improved this perspective but they require
      investments in laboratory infrastructure, biosafety and staff specialisation
      beyond the means of many resource-constrained settings where most patients live. 
      Xpert MTB/RIF, a new assay employing automated nucleic acid amplification to
      detect Mycobacterium tuberculosis, as well as mutations that confer rifampicin
      resistance, holds the promise to largely overcome these operational challenges.
      In this article we position Xpert MTB/RIF in today's TB diagnostic landscape and 
      describe its additional potential as an adjunct to surveillance and surveys,
      taking into account considerations of pricing and ethics. In what could serve as 
      a model for the future formulation of new policy on diagnostics, we trace the
      unique process by which the World Health Organization consulted international
      expertise and systematically assessed published evidence and freshly emerging
      experience from the field ahead of its endorsement of the Xpert MTB/RIF
      technology in 2010, summarise subsequent research findings and guidance on who to
      test and how, and provide perspectives on scaling up the new technology.
FAU - Weyer, Karin
AU  - Weyer K
AD  - Stop TB Dept, World Health Organization, Geneva, Switzerland.
FAU - Mirzayev, Fuad
AU  - Mirzayev F
FAU - Migliori, Giovanni Battista
AU  - Migliori GB
FAU - Van Gemert, Wayne
AU  - Van Gemert W
FAU - D'Ambrosio, Lia
AU  - D'Ambrosio L
FAU - Zignol, Matteo
AU  - Zignol M
FAU - Floyd, Katherine
AU  - Floyd K
FAU - Centis, Rosella
AU  - Centis R
FAU - Cirillo, Daniela M
AU  - Cirillo DM
FAU - Tortoli, Enrico
AU  - Tortoli E
FAU - Gilpin, Chris
AU  - Gilpin C
FAU - de Dieu Iragena, Jean
AU  - de Dieu Iragena J
FAU - Falzon, Dennis
AU  - Falzon D
FAU - Raviglione, Mario
AU  - Raviglione M
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121122
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
SB  - IM
CIN - Eur Respir J. 2014 Jul;44(1):1-4. PMID: 24982045
MH  - Cost-Benefit Analysis
MH  - Drug Resistance
MH  - Health Policy
MH  - Humans
MH  - Molecular Diagnostic Techniques/economics/*methods
MH  - Mycobacterium tuberculosis/genetics
MH  - Nucleic Acid Amplification Techniques
MH  - Polymerase Chain Reaction
MH  - Predictive Value of Tests
MH  - Prevalence
MH  - Reproducibility of Results
MH  - Sputum/microbiology
MH  - Tuberculosis, Multidrug-Resistant/*diagnosis/*microbiology
MH  - Tuberculosis, Pulmonary/diagnosis/*microbiology
MH  - World Health Organization
EDAT- 2012/11/28 06:00
MHDA- 2014/02/07 06:00
CRDT- 2012/11/28 06:00
PHST- 2012/11/28 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2014/02/07 06:00 [medline]
AID - 09031936.00157212 [pii]
AID - 10.1183/09031936.00157212 [doi]
PST - ppublish
SO  - Eur Respir J. 2013 Jul;42(1):252-71. doi: 10.1183/09031936.00157212. Epub 2012
      Nov 22.


PMID- 23180338
OWN - NLM
STAT- MEDLINE
DCOM- 20140305
LR  - 20211021
IS  - 1176-7529 (Print)
IS  - 1176-7529 (Linking)
VI  - 9
IP  - 3
DP  - 2012 Sep
TI  - Mediation and surrogate decision-making for LGBTQ families in the absence of an
      advance directive : comment on "Ethical challenges in end-of-life care for GLBTI 
      individuals" by Colleen Cartwright.
PG  - 365-7
LID - 10.1007/s11673-012-9387-6 [doi]
AB  - In this commentary on a clinical ethics case pertaining to a same-sex couple that
      does not have explicit surrogate decision-making or hospital-visitation rights
      (in the face of objections from the family-of-origin of one of the queer
      partners), the authors invoke contemporary legal and policy standards on LGBTQ
      health care in the United States and abroad. Given this historical moment in
      which some clinical rights are guaranteed for LGBTQ families whilst others are in
      transition, the authors advocate for the implementation of clinical ethics
      mediation as the soundest and most humane form of resolution in matters where
      there is a dispute between family members about an incapacitated loved one. They 
      argue that clinical ethics mediation is an ideal alternative solution because it 
      works toward consensus about outcome, even where consensus about values is not
      achievable.
FAU - Wahlert, Lance
AU  - Wahlert L
AD  - Department of Medical Ethics and Health Policy, Perelman School of Medicine,
      University of Pennsylvania, Philadelphia, PA 19104, USA.
      lwahlert@mail.med.upenn.edu
FAU - Fiester, Autumn
AU  - Fiester A
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20120801
PL  - Netherlands
TA  - J Bioeth Inq
JT  - Journal of bioethical inquiry
JID - 101250741
SB  - IM
CON - J Bioeth Inq. 2012 Mar;9(1):113-4. PMID: 23180206
MH  - Female
MH  - *Homosexuality, Female
MH  - Humans
MH  - Terminal Care/*legislation & jurisprudence
EDAT- 2012/11/28 06:00
MHDA- 2014/03/07 06:00
CRDT- 2012/11/27 06:00
PHST- 2012/07/01 00:00 [received]
PHST- 2012/07/02 00:00 [accepted]
PHST- 2012/11/27 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2014/03/07 06:00 [medline]
AID - 10.1007/s11673-012-9387-6 [doi]
PST - ppublish
SO  - J Bioeth Inq. 2012 Sep;9(3):365-7. doi: 10.1007/s11673-012-9387-6. Epub 2012 Aug 
      1.


PMID- 23180337
OWN - NLM
STAT- MEDLINE
DCOM- 20140305
LR  - 20211021
IS  - 1176-7529 (Print)
IS  - 1176-7529 (Linking)
VI  - 9
IP  - 3
DP  - 2012 Sep
TI  - Gay rights one baby-step at a time: protecting hospital visitation rights for
      same-sex partners while the lack of surrogacy rights lingers: comment on "Ethical
      challenges in end-of-life care for GLBTI individuals" by Colleen Cartwright.
PG  - 361-3
LID - 10.1007/s11673-012-9388-5 [doi]
AB  - Recognizing that GLBTI individuals are often barred from visiting their partners 
      in hospitals or from acting as health care surrogates for incapacitated partners,
      President Obama directed the Department of Health and Human Services to address
      these issues. In response, the department amended its rules to prohibit hospitals
      from restricting, limiting, or denying visitation privileges on the basis of
      gender identity or sexual orientation. But the changes do not affect the
      designation of a health care surrogate, a matter largely governed by state law.
      Therefore, subject to state law, same-sex partners can still be legally barred
      from making health care decisions for their incapacitated partners, and it
      remains essential that they execute advance directives and appoint one another as
      their health care proxies.
FAU - Hernandez, Jaime O
AU  - Hernandez JO
AD  - Hughes Hubbard & Reed, L.L.P., New York, NY 10004, USA.
      hernanj1@hugheshubbard.com
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20120731
PL  - Netherlands
TA  - J Bioeth Inq
JT  - Journal of bioethical inquiry
JID - 101250741
SB  - IM
CON - J Bioeth Inq. 2012 Mar;9(1):113-4. PMID: 23180206
MH  - Female
MH  - *Homosexuality, Female
MH  - Humans
MH  - Terminal Care/*legislation & jurisprudence
EDAT- 2012/11/28 06:00
MHDA- 2014/03/07 06:00
CRDT- 2012/11/27 06:00
PHST- 2012/06/29 00:00 [received]
PHST- 2012/06/30 00:00 [accepted]
PHST- 2012/11/27 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2014/03/07 06:00 [medline]
AID - 10.1007/s11673-012-9388-5 [doi]
PST - ppublish
SO  - J Bioeth Inq. 2012 Sep;9(3):361-3. doi: 10.1007/s11673-012-9388-5. Epub 2012 Jul 
      31.


PMID- 23180331
OWN - NLM
STAT- MEDLINE
DCOM- 20140305
LR  - 20211021
IS  - 1176-7529 (Print)
IS  - 1176-7529 (Linking)
VI  - 9
IP  - 3
DP  - 2012 Sep
TI  - The ethics of fertility preservation in transgender body modifications.
PG  - 311-6
LID - 10.1007/s11673-012-9378-7 [doi]
AB  - In some areas of clinical medicine, discussions about fertility preservation are 
      routine, such as in the treatment of children and adolescents facing cancer
      treatments that will destroy their ability to produce gametes of their own.
      Certain professional organizations now offer guidelines for people who wish to
      modify their bodies and appearance in regard to sex traits, and these guidelines 
      extend to recommendations about fertility preservation. Since the removal of
      testicles or ovaries will destroy the ability to have genetically related
      children later on, it is imperative to counsel transgender people seeking body
      modifications about fertility preservation options. Fertility preservation with
      transgender people will, however, lead to unconventional outcomes. If transgender
      men and women use their ova and sperm, respectively, to have children, they will 
      function as a mother or father in a gametic sense but will function in socially
      reversed parental identities. There is nothing, however, about fertility
      preservation with transgender men and women that is objectionable in its motives,
      practices, or outcomes that would justify closing off these options. In any case,
      novel reproductive technologies may extend this kind of role reversal in
      principle to all people, if sperm and ova can be derived from all human beings
      regardless of sex, as has happened with certain laboratory animals.
FAU - Murphy, Timothy F
AU  - Murphy TF
AD  - Department of Medical Education m/c 591, University of Illinois College of
      Medicine at Chicago, Chicago, IL 60612-7309, USA. tmurphy@uic.edu
LA  - eng
PT  - Journal Article
DEP - 20120724
PL  - Netherlands
TA  - J Bioeth Inq
JT  - Journal of bioethical inquiry
JID - 101250741
SB  - IM
MH  - Adolescent
MH  - Counseling
MH  - Female
MH  - Fertility Preservation/*ethics
MH  - Humans
MH  - Male
MH  - Minors
MH  - Sex Reassignment Surgery/*ethics
MH  - United States
EDAT- 2012/11/28 06:00
MHDA- 2014/03/07 06:00
CRDT- 2012/11/27 06:00
PHST- 2012/04/10 00:00 [received]
PHST- 2012/05/14 00:00 [accepted]
PHST- 2012/11/27 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2014/03/07 06:00 [medline]
AID - 10.1007/s11673-012-9378-7 [doi]
PST - ppublish
SO  - J Bioeth Inq. 2012 Sep;9(3):311-6. doi: 10.1007/s11673-012-9378-7. Epub 2012 Jul 
      24.


PMID- 23180330
OWN - NLM
STAT- MEDLINE
DCOM- 20140305
LR  - 20211021
IS  - 1176-7529 (Print)
IS  - 1176-7529 (Linking)
VI  - 9
IP  - 3
DP  - 2012 Sep
TI  - The cost of science : knowledge and ethics in the HIV pre-exposure prophylaxis
      trials.
PG  - 295-310
LID - 10.1007/s11673-012-9383-x [doi]
AB  - Over the past decade AIDS research has turned toward the use of pharmacology in
      HIV prevention, including pre-exposure prophylaxis (PrEP): the use of HIV
      medication as a means of preventing HIV acquisition in those who do not have it. 
      This paper explores the contradictory reasons offered in support of PrEP-to
      empower women, to provide another risk-reduction option for gay men-as the
      context for understanding the social meaning of the experimental trials that
      appear to show that PrEP works in gay men and heterosexual couples but not single
      women. The PrEP debates reveal the different ideas about "demedicalization" in
      the earlier gay health and women's health movements and highlight the
      relationship between health activism and critique of research ethics in the
      context of a global pharmaceutical market.
FAU - Patton, Cindy
AU  - Patton C
AD  - Sociology and Anthropology and Canada Research Chair in Community, Culture and
      Health, Simon Fraser University, Burnaby, Canada. ckpatton@sfu.ca
FAU - Kim, Hye Jin
AU  - Kim HJ
LA  - eng
PT  - Journal Article
DEP - 20120714
PL  - Netherlands
TA  - J Bioeth Inq
JT  - Journal of bioethical inquiry
JID - 101250741
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - Anti-HIV Agents/adverse effects/*therapeutic use
MH  - Developing Countries
MH  - Epidemiologic Methods
MH  - *Ethics, Research
MH  - Female
MH  - HIV Infections/*prevention & control
MH  - Harm Reduction/*ethics
MH  - Heterosexuality
MH  - Homosexuality, Male
MH  - Humans
MH  - Male
MH  - Risk
MH  - Women's Health
EDAT- 2012/11/28 06:00
MHDA- 2014/03/07 06:00
CRDT- 2012/11/27 06:00
PHST- 2012/04/20 00:00 [received]
PHST- 2012/05/18 00:00 [accepted]
PHST- 2012/11/27 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2014/03/07 06:00 [medline]
AID - 10.1007/s11673-012-9383-x [doi]
PST - ppublish
SO  - J Bioeth Inq. 2012 Sep;9(3):295-310. doi: 10.1007/s11673-012-9383-x. Epub 2012
      Jul 14.


PMID- 23180327
OWN - NLM
STAT- MEDLINE
DCOM- 20140305
LR  - 20211021
IS  - 1176-7529 (Print)
IS  - 1176-7529 (Linking)
VI  - 9
IP  - 3
DP  - 2012 Sep
TI  - Questioning scrutiny: bioethics, sexuality, and gender identity.
PG  - 243-8
LID - 10.1007/s11673-012-9376-9 [doi]
AB  - The clinic is a loaded space for LGBTQI persons. Historically a site of pathology
      and culturally a site of stigma, the contemporary clinic for queer patient
      populations and their loved ones is an ethically fraught space. This paper, which
      introduces the featured articles of this special issue of the Journal of
      Bioethical Inquiry on "Bioethics, Sexuality, and Gender Identity," begins by
      offering an analysis of scrutiny itself. How do we scrutinize? When is it apt for
      us to scrutinize? And what are the benefits and perils of clinical and bioethical
      scrutiny? Bearing in mind these questions, the second half of this paper
      introduces the feature articles in this special issue in response to such forms
      of scrutiny. How, why, when, and in what ways to sensitively scrutinize LGBTQI
      persons in the clinic are the aims of this piece.
FAU - Wahlert, Lance
AU  - Wahlert L
FAU - Fiester, Autumn
AU  - Fiester A
LA  - eng
PT  - Journal Article
DEP - 20120718
PL  - Netherlands
TA  - J Bioeth Inq
JT  - Journal of bioethical inquiry
JID - 101250741
SB  - IM
MH  - *Bisexuality
MH  - Health Services/*ethics
MH  - *Homosexuality
MH  - Humans
MH  - *Social Stigma
MH  - *Transgender Persons
EDAT- 2012/11/28 06:00
MHDA- 2014/03/07 06:00
CRDT- 2012/11/27 06:00
PHST- 2012/05/30 00:00 [received]
PHST- 2012/06/01 00:00 [accepted]
PHST- 2012/11/27 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2014/03/07 06:00 [medline]
AID - 10.1007/s11673-012-9376-9 [doi]
PST - ppublish
SO  - J Bioeth Inq. 2012 Sep;9(3):243-8. doi: 10.1007/s11673-012-9376-9. Epub 2012 Jul 
      18.


PMID- 23180270
OWN - NLM
STAT- MEDLINE
DCOM- 20140305
LR  - 20211021
IS  - 1176-7529 (Print)
IS  - 1176-7529 (Linking)
VI  - 9
IP  - 2
DP  - 2012 Jun
TI  - The strange case of Dr. B and Mr. Hide: ethical sensitivity as a means to reflect
      upon one's actions in managing conflict of interest : comment on "Toward a
      sociology of conflict of interest in medical research" by Sarah Winch and Michael
      Sinnott.
PG  - 225-7
LID - 10.1007/s11673-012-9360-4 [doi]
FAU - Potvin, Marie-Josee
AU  - Potvin MJ
AD  - Programmes de bioethique, Department of Social and Preventive Medicine,
      Universite de Montreal, C.P. 6128, succ. Centre-ville, Montreal, Quebec, Canada, 
      H3C 3J7. marie-josee.potvin@umontreal.ca
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20120321
PL  - Netherlands
TA  - J Bioeth Inq
JT  - Journal of bioethical inquiry
JID - 101250741
SB  - IM
CON - J Bioeth Inq. 2012 Jun;9(2):221-2. PMID: 23180268
MH  - *Conflict of Interest
MH  - *Ethics Committees, Research
MH  - *Ethics, Research
MH  - Humans
EDAT- 2012/11/28 06:00
MHDA- 2014/03/07 06:00
CRDT- 2012/11/27 06:00
PHST- 2012/02/01 00:00 [received]
PHST- 2012/02/13 00:00 [accepted]
PHST- 2012/11/27 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2014/03/07 06:00 [medline]
AID - 10.1007/s11673-012-9360-4 [doi]
PST - ppublish
SO  - J Bioeth Inq. 2012 Jun;9(2):225-7. doi: 10.1007/s11673-012-9360-4. Epub 2012 Mar 
      21.


PMID- 23180260
OWN - NLM
STAT- MEDLINE
DCOM- 20140305
LR  - 20211021
IS  - 1176-7529 (Print)
IS  - 1176-7529 (Linking)
VI  - 9
IP  - 2
DP  - 2012 Jun
TI  - The moral difference or equivalence between continuous sedation until death and
      physician-assisted death: word games or war games?: a qualitative content
      analysis of opinion pieces in the indexed medical and nursing literature.
PG  - 171-83
LID - 10.1007/s11673-012-9369-8 [doi]
AB  - Continuous sedation until death (CSD), the act of reducing or removing the
      consciousness of an incurably ill patient until death, often provokes
      medical-ethical discussions in the opinion sections of medical and nursing
      journals. Some argue that CSD is morally equivalent to physician-assisted death
      (PAD), that it is a form of "slow euthanasia." A qualitative thematic content
      analysis of opinion pieces was conducted to describe and classify arguments that 
      support or reject a moral difference between CSD and PAD. Arguments pro and
      contra a moral difference refer basically to the same ambiguous themes, namely
      intention, proportionality, withholding artificial nutrition and hydration, and
      removing consciousness. This demonstrates that the debate is first and foremost a
      semantic rather than a factual dispute, focusing on the normative framework of
      CSD. Given the prevalent ambiguity, the debate on CSD appears to be a classical
      symbolic struggle for moral authority.
FAU - Rys, Sam
AU  - Rys S
AD  - Department of Public Health, Faculty of Medicine and Pharmacy, Vrije Universiteit
      Brussel, Laarbeeklaan 103, 1090, Brussel, Belgium. samrys@vub.ac.be
FAU - Deschepper, Reginald
AU  - Deschepper R
FAU - Mortier, Freddy
AU  - Mortier F
FAU - Deliens, Luc
AU  - Deliens L
FAU - Atkinson, Douglas
AU  - Atkinson D
FAU - Bilsen, Johan
AU  - Bilsen J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120321
PL  - Netherlands
TA  - J Bioeth Inq
JT  - Journal of bioethical inquiry
JID - 101250741
SB  - IM
MH  - Deep Sedation/*ethics
MH  - Humans
MH  - Morals
MH  - Palliative Care/*ethics
MH  - Qualitative Research
MH  - Semantics
MH  - Suicide, Assisted/*ethics
MH  - Symbolism
MH  - Terminal Care/*ethics
EDAT- 2012/11/28 06:00
MHDA- 2014/03/07 06:00
CRDT- 2012/11/27 06:00
PHST- 2011/09/05 00:00 [received]
PHST- 2012/02/05 00:00 [accepted]
PHST- 2012/11/27 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2014/03/07 06:00 [medline]
AID - 10.1007/s11673-012-9369-8 [doi]
PST - ppublish
SO  - J Bioeth Inq. 2012 Jun;9(2):171-83. doi: 10.1007/s11673-012-9369-8. Epub 2012 Mar
      21.


PMID- 23180254
OWN - NLM
STAT- MEDLINE
DCOM- 20130227
LR  - 20181202
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 12
DP  - 2012 Dec
TI  - Deciphering the appropriateness of defaults: the need for domain-specific
      evidence.
PG  - 721-2
LID - 10.1136/medethics-2012-100724 [doi]
AB  - In this issue of The Journal of Medical Ethics, xxx and colleagues report a
      randomized trial of the influence of default options on delivery room management 
      of an extremely premature infant. They report that among respondents to the
      hypothetical vignette, those who received the resuscitation default were
      significantly more likely to choose resuscitation compared with those who were
      told that the default was comfort care. While the results warrant attention and
      further investigation, several methodological shortcomings limit the conclusions 
      that can be drawn from this study.
FAU - Quill, Caroline Mayberry
AU  - Quill CM
AD  - Department of Pulmonary, Allergy and Critical Care, University of Pennsylvania
      Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA.
FAU - Halpern, Scott
AU  - Halpern S
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
CON - J Med Ethics. 2012 Dec;38(12):713-8. PMID: 23180252
MH  - Decision Making/*ethics
MH  - *Delivery Rooms
MH  - *Disclosure
MH  - Female
MH  - Humans
MH  - *Infant, Extremely Premature
MH  - Male
MH  - Palliative Care/*ethics
MH  - *Personal Autonomy
MH  - *Persuasive Communication
MH  - Resuscitation Orders/*ethics
EDAT- 2012/11/28 06:00
MHDA- 2013/02/28 06:00
CRDT- 2012/11/27 06:00
PHST- 2012/11/27 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/02/28 06:00 [medline]
AID - medethics-2012-100724 [pii]
AID - 10.1136/medethics-2012-100724 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Dec;38(12):721-2. doi: 10.1136/medethics-2012-100724.


PMID- 23180197
OWN - NLM
STAT- MEDLINE
DCOM- 20131224
LR  - 20220129
IS  - 1176-7529 (Print)
IS  - 1176-7529 (Linking)
VI  - 9
IP  - 1
DP  - 2012 Mar
TI  - Donating embryos to stem cell research.
PG  - 19-28
LID - 10.1007/s11673-011-9352-9 [doi]
AB  - This paper is based on linked qualitative studies of the donation of human
      embryos to stem cell research carried out in the United Kingdom, Switzerland, and
      China. All three studies used semi-structured interview protocols to allow an
      in-depth examination of donors' and non-donors' rationales for their donation
      decisions, with the aim of gaining information on contextual and other factors
      that play a role in donor decisions and identifying how these relate to factors
      that are more usually included in evaluations made by theoretical ethics. Our
      findings have implications for one factor that has previously been suggested as
      being of ethical concern: the role of gratitude. Our empirical work shows no
      evidence that interpersonal gratitude is an important factor, but it does support
      the existence of a solidarity-based desire to "give something back" to medical
      research. Thus, we use empirical data to expand and refine the conceptual basis
      of bioethically theorizing the IVF-stem cell interface.
FAU - Scully, Jackie Leach
AU  - Scully JL
AD  - Policy, Ethics and Life Sciences Research Centre, Newcastle University, Claremont
      Bridge, Claremont Road, Newcastle NE1 7RU, UK. Jackie.scully@ncl.ac.uk
FAU - Haimes, Erica
AU  - Haimes E
FAU - Mitzkat, Anika
AU  - Mitzkat A
FAU - Porz, Rouven
AU  - Porz R
FAU - Rehmann-Sutter, Christoph
AU  - Rehmann-Sutter C
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - G0701109/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120104
PL  - Netherlands
TA  - J Bioeth Inq
JT  - Journal of bioethical inquiry
JID - 101250741
SB  - IM
MH  - Embryo Disposition/*ethics
MH  - Embryo Research/*ethics
MH  - *Embryonic Stem Cells
MH  - Humans
MH  - Reproductive Techniques, Assisted/ethics
PMC - PMC3714553
EDAT- 2012/11/28 06:00
MHDA- 2013/12/25 06:00
CRDT- 2012/11/27 06:00
PHST- 2011/09/25 00:00 [received]
PHST- 2011/11/17 00:00 [accepted]
PHST- 2012/11/27 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/12/25 06:00 [medline]
AID - 10.1007/s11673-011-9352-9 [doi]
PST - ppublish
SO  - J Bioeth Inq. 2012 Mar;9(1):19-28. doi: 10.1007/s11673-011-9352-9. Epub 2012 Jan 
      4.


PMID- 23180120
OWN - NLM
STAT- MEDLINE
DCOM- 20140305
LR  - 20211021
IS  - 1176-7529 (Print)
IS  - 1176-7529 (Linking)
VI  - 9
IP  - 4
DP  - 2012 Dec
TI  - The dilemma of revealing sensitive information on paternity status in Arabian
      social and cultural contexts: telling the truth about paternity in Saudi Arabia.
PG  - 403-9
LID - 10.1007/s11673-012-9390-y [doi]
AB  - Telling the truth is one of the most respected virtues in medical history and one
      of the most emphasized in the code of medical ethics. Health care providers are
      frequently confronted with the dilemma as to whether or not to tell the truth.
      This dilemma deepens when both choices are critically vicious: The choice is no
      longer between "right and right" or "right and wrong," it is between "wrong and
      wrong." In the case presented and discussed in this paper, a research team in
      Saudi Arabia unintentionally uncovered information regarding misattributed
      paternity. In such a situation and in the context of a tribal cultural system,
      what should the team do with this information? This case analysis demonstrates
      the joint application of ethical resources originating from within and outside
      the Saudi Arabian context. The article analyses the case based on the moral
      problems involved, relevant medical application, and the impact of such
      information in the Saudi tribal and Islamic domains. The most pertinent relevant 
      values and secular debates on similar matters are discussed. Finally, the article
      aims to provide an Islamic dimension of family, fatherhood, and adultery.
FAU - Adlan, Abdallah A
AU  - Adlan AA
AD  - King Abdullah International Medical Research Centre, King Saud bin Abdulaziz
      University for Health Sciences, P.O. Box 22490, Riyadh, 11426, Saudi Arabia.
      aadlan@hotmail.com
FAU - ten Have, Henk A M J
AU  - ten Have HA
LA  - eng
PT  - Journal Article
DEP - 20121012
PL  - Netherlands
TA  - J Bioeth Inq
JT  - Journal of bioethical inquiry
JID - 101250741
SB  - IM
CIN - J Bioeth Inq. 2012 Dec;9(4):411-2. PMID: 23180121
CIN - J Bioeth Inq. 2012 Dec;9(4):413-4. PMID: 23188398
CIN - J Bioeth Inq. 2012 Dec;9(4):415-6. PMID: 23188399
CIN - J Bioeth Inq. 2012 Dec;9(4):417-8. PMID: 23188400
MH  - Adolescent
MH  - Beneficence
MH  - Female
MH  - Genetic Diseases, Inborn/genetics
MH  - Genetic Research/*ethics
MH  - Humans
MH  - *Islam
MH  - Male
MH  - *Paternity
MH  - Physician-Patient Relations/ethics
MH  - Saudi Arabia
MH  - Social Values
MH  - Trust
MH  - Truth Disclosure/*ethics
EDAT- 2012/11/28 06:00
MHDA- 2014/03/07 06:00
CRDT- 2012/11/27 06:00
PHST- 2010/12/13 00:00 [received]
PHST- 2012/08/27 00:00 [accepted]
PHST- 2012/11/27 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2014/03/07 06:00 [medline]
AID - 10.1007/s11673-012-9390-y [doi]
PST - ppublish
SO  - J Bioeth Inq. 2012 Dec;9(4):403-9. doi: 10.1007/s11673-012-9390-y. Epub 2012 Oct 
      12.


PMID- 23179971
OWN - NLM
STAT- MEDLINE
DCOM- 20130926
LR  - 20211021
IS  - 1525-1497 (Electronic)
IS  - 0884-8734 (Linking)
VI  - 28
IP  - 4
DP  - 2013 Apr
TI  - Learning by doing: effectively incorporating ethics education into residency
      training.
PG  - 578-82
LID - 10.1007/s11606-012-2277-0 [doi]
AB  - BACKGROUND: Medical ethics is a critical component of the curriculum for clinical
      trainees. Educational initiatives should adapt content to participants'
      experience in order to ensure relevance and retain their interest. AIM: To
      develop and evaluate an experiential educational program for physicians. SETTING:
      Academic medical center. PARTICIPANTS: Senior internal medicine residents (n =
      40). PROGRAM DESCRIPTION: A case-based didactic program was designed in which
      each resident shared a difficult ethics case from their clinical experience. We
      created a curriculum around these cases involving formal didactics as well as
      open-ended discussion and summarized the ethical issues most relevant to the
      participants. A course survey was administered based upon the validated Students'
      Evaluation of Educational Quality (SEEQ). PROGRAM EVALUATION: Common issues
      raised included surrogate decision-making (18 %), refusal of treatment (14 %),
      capacity/informed consent (10 %), and medical futility (10 %). Mean SEEQ subscale
      scores for learning value, organization/clarity, group interaction, breadth of
      coverage, and assignments/readings were 4.5 (maximum possible score 5). Residents
      unanimously rated the course overall as good/very good, and all agreed or
      strongly agreed that the course was useful and its structure effective.
      DISCUSSION: An experiential case-based didactic program in medical ethics engaged
      adult learners and facilitated a comprehensive and clinically relevant
      educational initiative.
FAU - Vertrees, Stephanie M
AU  - Vertrees SM
AD  - Division of Medical Ethics, Weill Cornell Medical College, 435 E. 70th St. Suite 
      4-J, New York, NY 10021, USA.
FAU - Shuman, Andrew G
AU  - Shuman AG
FAU - Fins, Joseph J
AU  - Fins JJ
LA  - eng
PT  - Journal Article
DEP - 20121121
PL  - United States
TA  - J Gen Intern Med
JT  - Journal of general internal medicine
JID - 8605834
SB  - IM
MH  - Academic Medical Centers/organization & administration
MH  - Attitude of Health Personnel
MH  - Curriculum
MH  - Education, Medical, Graduate/methods/*organization & administration
MH  - Ethics, Medical/*education
MH  - Humans
MH  - Internal Medicine/education
MH  - Internship and Residency/*organization & administration
MH  - Medical Records
MH  - New York
MH  - Problem-Based Learning/methods/*organization & administration
MH  - Program Evaluation
PMC - PMC3599016
EDAT- 2012/11/28 06:00
MHDA- 2013/09/27 06:00
CRDT- 2012/11/27 06:00
PHST- 2012/05/03 00:00 [received]
PHST- 2012/10/26 00:00 [accepted]
PHST- 2012/08/29 00:00 [revised]
PHST- 2012/11/27 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/09/27 06:00 [medline]
AID - 10.1007/s11606-012-2277-0 [doi]
PST - ppublish
SO  - J Gen Intern Med. 2013 Apr;28(4):578-82. doi: 10.1007/s11606-012-2277-0. Epub
      2012 Nov 21.


PMID- 23179959
OWN - NLM
STAT- MEDLINE
DCOM- 20140520
LR  - 20180509
IS  - 1437-7780 (Electronic)
IS  - 1341-321X (Linking)
VI  - 19
IP  - 4
DP  - 2013 Aug
TI  - Reevaluation of the Japanese guideline for healthcare-associated pneumonia in a
      medium-sized community hospital in Japan.
PG  - 579-87
LID - 10.1007/s10156-012-0517-1 [doi]
AB  - The Japanese guidelines for nursing- and healthcare-associated pneumonia (NHCAP) 
      categorize patients by risk of resistant bacteria and defined antimicrobials to
      be used, similar to the healthcare-associated pneumonia (HCAP) guidelines of the 
      United States. The data were collected in large-scale hospitals, possibly a cause
      of inconsistency with everyday practice in medium-sized community hospitals. To
      test the feasibility of this guideline based on a retrospective study performed
      in a medium-sized community hospital in Japan, the medical records of pneumonia
      patients were retrospectively studied [718 patients: NHCAP, 477, 66.4 %;
      community-acquired pneumonia (CAP), 241, 33.4 %). Factors related to patients'
      background, clinical and laboratory findings, treatment, and outcome were
      compared between NHCAP and CAP. The A-DROP system, scored by age, dehydration,
      respiratory failure, disorientation, and low blood pressure, evaluated the
      severity of pneumonia. In contrast to CAP patients, NHCAP patients included more 
      elderly patients requiring nursing care and revealed higher rates of poor
      nutrition, dementia, aspiration, severe cases, detection of drug-resistant
      bacteria, and mortality. For NHCAP, the success rate did not differ between those
      receiving and not receiving proper initial treatment (76.9 vs. 78.5 %) nor did
      mortality rate within 30 days differ (13.1 vs. 13.8 %). Risk factors for
      mortality within 30 days for NHCAP were diabetes [adjusted odds ratio (AOR)
      2.394, p = 0.009], albumin <2.5 g/dl (AOR 2.766, p = 0.002), A-DROP very severe
      (AOR 1.930, p = 0.021), and imaging showing extensive pneumonia (AOR 2.541, p =
      0.002). The severity of pneumonia rather than risk of resistant bacteria should
      be considered, in addition to ethical concerns, in initial treatment strategy in 
      NHCAP to avoid excessive use of broad-spectrum antimicrobials.
FAU - Oshitani, Yohei
AU  - Oshitani Y
AD  - Center for Pulmonary Diseases, National Hospital Organization, Tokyo National
      Hospital, 3-1-1 Takeoka, Kiyose, Tokyo, 204-8585, Japan.
      yohei_oshi_nhotokyo@yahoo.co.jp
FAU - Nagai, Hideaki
AU  - Nagai H
FAU - Matsui, Hirotoshi
AU  - Matsui H
FAU - Aoshima, Masahiro
AU  - Aoshima M
LA  - eng
PT  - Journal Article
DEP - 20121122
PL  - Netherlands
TA  - J Infect Chemother
JT  - Journal of infection and chemotherapy : official journal of the Japan Society of 
      Chemotherapy
JID - 9608375
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Anti-Bacterial Agents/pharmacology/*therapeutic use
MH  - Bacteria/drug effects/isolation & purification
MH  - Cross Infection/*drug therapy/epidemiology/microbiology/mortality
MH  - Drug Resistance, Bacterial
MH  - Female
MH  - Hospitals, Community
MH  - Humans
MH  - Japan
MH  - Male
MH  - Nursing Homes
MH  - Odds Ratio
MH  - Pneumonia, Bacterial/*drug therapy/epidemiology/microbiology/mortality
MH  - Practice Guidelines as Topic
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Statistics, Nonparametric
MH  - Treatment Outcome
EDAT- 2012/11/28 06:00
MHDA- 2014/05/21 06:00
CRDT- 2012/11/27 06:00
PHST- 2012/08/14 00:00 [received]
PHST- 2012/11/02 00:00 [accepted]
PHST- 2012/11/27 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2014/05/21 06:00 [medline]
AID - 10.1007/s10156-012-0517-1 [doi]
AID - S1341-321X(13)70083-7 [pii]
PST - ppublish
SO  - J Infect Chemother. 2013 Aug;19(4):579-87. doi: 10.1007/s10156-012-0517-1. Epub
      2012 Nov 22.


PMID- 23179069
OWN - NLM
STAT- MEDLINE
DCOM- 20131122
LR  - 20171107
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 18
IP  - 4
DP  - 2012 Dec
TI  - On the use of the concept of "fairness" in ethics.
PG  - 601-3
LID - 10.1007/s11948-012-9420-5 [doi]
FAU - Spier, Raymond E
AU  - Spier RE
LA  - eng
PT  - Editorial
DEP - 20121123
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
CIN - Sci Eng Ethics. 2013 Jun;19(2):311. PMID: 23640174
MH  - Humans
MH  - *Social Justice
EDAT- 2012/11/28 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/11/27 06:00
PHST- 2011/02/01 00:00 [received]
PHST- 2012/11/09 00:00 [accepted]
PHST- 2012/11/27 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1007/s11948-012-9420-5 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2012 Dec;18(4):601-3. doi: 10.1007/s11948-012-9420-5. Epub 2012
      Nov 23.


PMID- 23179067
OWN - NLM
STAT- MEDLINE
DCOM- 20140122
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 3
DP  - 2013 Sep
TI  - Karl Pearson and eugenics: personal opinions and scientific rigor.
PG  - 1057-70
LID - 10.1007/s11948-012-9415-2 [doi]
AB  - The influence of personal opinions and biases on scientific conclusions is a
      threat to the advancement of knowledge. Expertise and experience does not render 
      one immune to this temptation. In this work, one of the founding fathers of
      statistics, Karl Pearson, is used as an illustration of how even the most
      talented among us can produce misleading results when inferences are made without
      caution or reference to potential bias and other analysis limitations. A study
      performed by Pearson on British Jewish schoolchildren is examined in light of
      ethical and professional statistical practice. The methodology used and
      inferences made by Pearson and his coauthor are sometimes questionable and offer 
      insight into how Pearson's support of eugenics and his own British nationalism
      could have potentially influenced his often careless and far-fetched inferences. 
      A short background into Pearson's work and beliefs is provided, along with an
      in-depth examination of the authors' overall experimental design and statistical 
      practices. In addition, portions of the study regarding intelligence and
      tuberculosis are discussed in more detail, along with historical reactions to
      their work.
FAU - Delzell, Darcie A P
AU  - Delzell DA
AD  - Department of Mathematics and Computer Science, Wheaton College, Wheaton, IL
      60187, USA. darcie.delzell@wheaton.edu
FAU - Poliak, Cathy D
AU  - Poliak CD
LA  - eng
PT  - Biography
PT  - Historical Article
PT  - Journal Article
DEP - 20121121
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Child
MH  - Emigrants and Immigrants/*history
MH  - Eugenics/*history
MH  - History, 19th Century
MH  - History, 20th Century
MH  - Humans
MH  - *Intelligence
MH  - Jews/history
MH  - Research Design
MH  - Statistics as Topic/ethics/*history
MH  - Tuberculosis/*history
MH  - United Kingdom
PS  - Pearson K
FPS - Pearson, Karl
EDAT- 2012/11/28 06:00
MHDA- 2014/01/23 06:00
CRDT- 2012/11/27 06:00
PHST- 2012/08/23 00:00 [received]
PHST- 2012/11/04 00:00 [accepted]
PHST- 2012/11/27 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2014/01/23 06:00 [medline]
AID - 10.1007/s11948-012-9415-2 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Sep;19(3):1057-70. doi: 10.1007/s11948-012-9415-2. Epub 2012
      Nov 21.


PMID- 23179036
OWN - NLM
STAT- MEDLINE
DCOM- 20130604
LR  - 20211203
IS  - 1529-8795 (Electronic)
IS  - 0031-5982 (Linking)
VI  - 55
IP  - 3
DP  - 2012 Summer
TI  - From bedside to blackboard: the benefits of teaching molecular biology within a
      medical context.
PG  - 461-6
LID - 10.1353/pbm.2012.0030 [doi]
AB  - Courses in molecular biology are part of practically every degree program in
      medicine and the life sciences. Historically, many basic discoveries in this
      field have resulted from investigations by doctors into the nature of diseases.
      This essay suggests that medical educators deliberately incorporate such
      material, whether historical or contemporaneous, into their molecular and cell
      biology courses. An example of such usage, an early report of the detection of
      bacteriophage activity on pathogenic bacteria, is discussed in detail. Such an
      approach can potentially narrow the perceived gap between "basic" and "applied"
      science. As medicine is so intimately and obviously linked with human welfare,
      this also provides an avenue for educators to discuss issues of scientific
      integrity and ethics within a "pure science" course.
FAU - Sitaraman, Ramakrishnan
AU  - Sitaraman R
AD  - Department of Biotechnology, TERI University, 10 Institutional Area,Vasant Kunj, 
      New Delhi 110070, India. minraj@gmail.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Perspect Biol Med
JT  - Perspectives in biology and medicine
JID - 0401132
SB  - IM
MH  - Bacteria/pathogenicity/virology
MH  - Bacteriophages
MH  - Curriculum
MH  - Education, Medical, Undergraduate/*methods
MH  - Humans
MH  - Molecular Biology/*education
MH  - *Students, Medical
MH  - Teaching/*methods
MH  - Translational Research, Biomedical/*education
EDAT- 2012/11/28 06:00
MHDA- 2013/06/05 06:00
CRDT- 2012/11/27 06:00
PHST- 2012/11/27 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/06/05 06:00 [medline]
AID - S1529879512300100 [pii]
AID - 10.1353/pbm.2012.0030 [doi]
PST - ppublish
SO  - Perspect Biol Med. 2012 Summer;55(3):461-6. doi: 10.1353/pbm.2012.0030.


PMID- 23179027
OWN - NLM
STAT- MEDLINE
DCOM- 20130604
LR  - 20121126
IS  - 1529-8795 (Electronic)
IS  - 0031-5982 (Linking)
VI  - 55
IP  - 3
DP  - 2012 Summer
TI  - The history of bioethics: implications for current debates in health research.
PG  - 329-38
LID - 10.1353/pbm.2012.0025 [doi]
AB  - The assumption that developments in technologies and societies create new ethical
      issues for health and medical research is intuitively appealing. However, a
      closer inspection of the history of bioethics reveals a surprising consistency in
      the core issues that have formed the basis of bioethical debates over time. If
      the issues involved in bioethical debates remain essentially constant, are new
      discussions and new guidelines and principles--produced in the wake of research
      scandals or inspired by the introduction of new technologies--redundant? This
      article examines some of the implications of the history of bioethics for
      understanding current ethical debates and for the formation of a culture of
      ethical conduct in health research.
FAU - McWhirter, R E
AU  - McWhirter RE
AD  - Menzies Research Institute Tasmania, University of Tasmania, Hobart TAS 7000,
      Australia. rebekah.mcwhirter@utas.edu.au
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - Perspect Biol Med
JT  - Perspectives in biology and medicine
JID - 0401132
SB  - IM
MH  - *Bioethical Issues/history
MH  - *Bioethics/history
MH  - Biomedical Research/*ethics/history
MH  - Codes of Ethics
MH  - Diffusion of Innovation
MH  - Health Services Research/*ethics/history
MH  - History, 19th Century
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
EDAT- 2012/11/28 06:00
MHDA- 2013/06/05 06:00
CRDT- 2012/11/27 06:00
PHST- 2012/11/27 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/06/05 06:00 [medline]
AID - S152987951230001X [pii]
AID - 10.1353/pbm.2012.0025 [doi]
PST - ppublish
SO  - Perspect Biol Med. 2012 Summer;55(3):329-38. doi: 10.1353/pbm.2012.0025.


PMID- 23178351
OWN - NLM
STAT- MEDLINE
DCOM- 20131104
LR  - 20181202
IS  - 1538-067X (Electronic)
IS  - 1092-1095 (Linking)
VI  - 16
IP  - 6
DP  - 2012 Dec
TI  - Nurses' responses to ethical challenges in oncology practice: an ethnographic
      study.
PG  - 592-600
LID - 10.1188/12.CJON.592-600 [doi]
AB  - Oncology nurses encounter increasingly complex ethical challenges in clinical
      practice. This ethnographic study explored 30 oncology nurses' descriptions of
      ethical situations and 12 key informants' perspectives on factors that influence 
      the development of ethically difficult situations. Nurses described the goals of 
      preventing patient suffering and injury, being honest with patients, and
      contributing meaningfully to patient improvement and stated goals. Nurses
      experienced six primary challenges in meeting their goals: being the eyes and
      arms of patient suffering, experiencing the precariousness of competing
      obligations, navigating the intricacies of hope and honesty, managing the urgency
      caused by waiting, straining to find time, and weighing risks of speaking up in
      hierarchal structures. Nurse actions included addressing concerns, creating other
      avenues, murmuring to one another, staying silent, and looking away. Several
      factors influenced nurses' responses to ethical challenges. Results imply a
      contextual model of moral action that reveals a need for altering practice
      environments in addition to improving nurses' ethics skills. Nurses are very
      aware of their moral responsibilities in ethically difficult situations and need 
      work environments conducive to interprofessional collaboration and open dialogue.
FAU - Pavlish, Carol
AU  - Pavlish C
AD  - School of Nursing, University of California, Los Angeles, USA.
      cpavlish@sonnet.ucla.edu
FAU - Brown-Saltzman, Katherine
AU  - Brown-Saltzman K
FAU - Jakel, Patricia
AU  - Jakel P
FAU - Rounkle, Ann-Marie
AU  - Rounkle AM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Clin J Oncol Nurs
JT  - Clinical journal of oncology nursing
JID - 9705336
MH  - Anthropology, Cultural/*ethics
MH  - Education, Nursing, Continuing
MH  - *Ethics, Nursing
MH  - Female
MH  - Humans
MH  - Male
MH  - *Oncology Nursing
MH  - Workforce
EDAT- 2012/11/28 06:00
MHDA- 2013/11/05 06:00
CRDT- 2012/11/27 06:00
PHST- 2012/11/27 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/11/05 06:00 [medline]
AID - C90212L79310970K [pii]
AID - 10.1188/12.CJON.592-600 [doi]
PST - ppublish
SO  - Clin J Oncol Nurs. 2012 Dec;16(6):592-600. doi: 10.1188/12.CJON.592-600.


PMID- 23178349
OWN - NLM
STAT- MEDLINE
DCOM- 20131104
LR  - 20191210
IS  - 1538-067X (Electronic)
IS  - 1092-1095 (Linking)
VI  - 16
IP  - 6
DP  - 2012 Dec
TI  - Patient safety and ethics: a conflict of goods.
PG  - 575-6
LID - 10.1188/12.CJON.575-576 [doi]
AB  - Nurses often face ethical dilemmas when providing care to patients with cancer.
      Although "doing the right thing" may seem obvious in the decision-making process,
      nurses are frequently challenged with a conflict of doing good regarding patient 
      safety and patient advocacy versus maintaining collegial relationships.
FAU - Hill, Joal
AU  - Hill J
AD  - Advocate Health Care, Park Ridge Center, Park Ridge, IL, USA.
      joal.hill@advocatehealth.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin J Oncol Nurs
JT  - Clinical journal of oncology nursing
JID - 9705336
MH  - *Conflict, Psychological
MH  - Decision Making
MH  - *Ethics, Nursing
MH  - Humans
MH  - Patient Advocacy
MH  - *Patient Safety
EDAT- 2012/11/28 06:00
MHDA- 2013/11/05 06:00
CRDT- 2012/11/27 06:00
PHST- 2012/11/27 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/11/05 06:00 [medline]
AID - RW5KL62711LH7441 [pii]
AID - 10.1188/12.CJON.575-576 [doi]
PST - ppublish
SO  - Clin J Oncol Nurs. 2012 Dec;16(6):575-6. doi: 10.1188/12.CJON.575-576.


PMID- 23177778
OWN - NLM
STAT- MEDLINE
DCOM- 20130306
LR  - 20121218
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 76
IP  - 1
DP  - 2013 Jan
TI  - Thai and American doctors on medical ethics: religion, regulation, and moral
      reasoning across borders.
PG  - 92-100
LID - 10.1016/j.socscimed.2012.10.010 [doi]
LID - S0277-9536(12)00732-0 [pii]
AB  - Recent scholarship argues that successful international medical collaboration
      depends crucially on improving cross-cultural understanding. To this end, this
      study analyzes recent writings on medical ethics by physicians in two countries
      actively participating in global medicine, Thailand and the United States.
      Articles (133; published 2004-2008) from JAMA, the New England Journal of
      Medicine, and the Journal of the Medical Association of Thailand are analyzed to 
      inductively build a portrait of two discursive ethical cultures. Frameworks of
      moral reasoning are identified across and within the two groups, with a focus on 
      what authority (religion, law, etc.) is invoked to define and evaluate ethical
      problems. How might similarities and differences in ethical paradigms reflect the
      countries' historical "semicolonial" relationship, shed light on debates about
      Eastern vs. Western bioethics, and facilitate or hinder contemporary
      cross-national communication? Findings demonstrate substantial overlap in Thai
      and American doctors' vocabulary, points of reference, and topics covered, though
      only Thai doctors emphasize national interests and identity. American authors
      display a striking homogeneity in styles of moral reasoning, embracing a secular,
      legalistic, deontological ethics that generally eschews discussion of religion,
      personal character, or national culture. Among Thai authors, there is a schism in
      ethical styles: while some hew closely to the secular, deontological model,
      others embrace a virtue ethics that liberally cites Buddhist principles and
      emphasizes the role of doctors' good character. These two approaches may
      represent opposing reactions-assimilation and resistance, respectively-to Western
      influence. The current findings undermine the stereotype of Western individualism
      versus Eastern collectivism. Implications for cross-national dialog are
      discussed.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Grol-Prokopczyk, Hanna
AU  - Grol-Prokopczyk H
AD  - Department of Sociology, University of Wisconsin-Madison, 8128 Sewell Social
      Sciences Building, 1180 Observatory Drive, Madison, WI 53706, United States.
      hgrol@ssc.wisc.edu
LA  - eng
PT  - Journal Article
DEP - 20121102
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - *Attitude of Health Personnel
MH  - *Cross-Cultural Comparison
MH  - Empirical Research
MH  - *Ethics, Medical
MH  - Humans
MH  - Moral Development
MH  - Periodicals as Topic/*statistics & numerical data
MH  - Physicians/*psychology/statistics & numerical data
MH  - Religion
MH  - Social Control, Formal
MH  - Thailand
MH  - United States
EDAT- 2012/11/28 06:00
MHDA- 2013/03/07 06:00
CRDT- 2012/11/27 06:00
PHST- 2012/03/19 00:00 [received]
PHST- 2012/10/05 00:00 [revised]
PHST- 2012/10/25 00:00 [accepted]
PHST- 2012/11/27 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/03/07 06:00 [medline]
AID - S0277-9536(12)00732-0 [pii]
AID - 10.1016/j.socscimed.2012.10.010 [doi]
PST - ppublish
SO  - Soc Sci Med. 2013 Jan;76(1):92-100. doi: 10.1016/j.socscimed.2012.10.010. Epub
      2012 Nov 2.


PMID- 23177722
OWN - NLM
STAT- MEDLINE
DCOM- 20140306
LR  - 20130902
IS  - 1873-6513 (Electronic)
IS  - 0885-3924 (Linking)
VI  - 46
IP  - 3
DP  - 2013 Sep
TI  - Oral nutrition or the ability to speak: the choice faced by a cancer survivor.
PG  - 452-5
LID - 10.1016/j.jpainsymman.2012.08.016 [doi]
LID - S0885-3924(12)00497-6 [pii]
AB  - Patients with head and neck cancer often suffer from breathing, speaking, and
      eating deficits, which negatively affect their quality of life. These patients
      are often observed to repeatedly contract aspiration pneumonia, resulting in
      prolonged hospital stays. To help prevent aspiration pneumonia, enteral nutrition
      is often provided. Although this method helps avoid pneumonia, patients need to
      give up eating by mouth. Because oral intake of food is closely related to
      patient quality of life, abandoning eating results in a strong internal conflict.
      This report describes the case of a cancer patient who experienced repeated
      aspiration pneumonias after neck surgery. The patient required enteral nutrition 
      to avoid repeated bouts of pneumonia. However, the patient opted for laryngeal
      closure surgery to regain the ability to take food orally, at the expense of his 
      voice. The patient's choice caused an ethical conflict for the attending medical 
      professionals, highlighting the need for physicians to communicate with their
      patients to understand their patients' sense of values.
CI  - Copyright (c) 2013 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. 
      All rights reserved.
FAU - Hatano, Yutaka
AU  - Hatano Y
AD  - Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural
      University of Medicine, Kyoto, Japan. yhatano@koto.kpu-m.ac.jp
FAU - Fujimoto, Sawako
AU  - Fujimoto S
FAU - Ikka, Tsunakuni
AU  - Ikka T
FAU - Hosokawa, Toyoshi
AU  - Hosokawa T
FAU - Fukui, Kenji
AU  - Fukui K
LA  - eng
PT  - Journal Article
DEP - 20121122
PL  - United States
TA  - J Pain Symptom Manage
JT  - Journal of pain and symptom management
JID - 8605836
SB  - IM
MH  - Aged
MH  - Decision Making/*ethics
MH  - Enteral Nutrition/*ethics
MH  - Humans
MH  - Male
MH  - Neoplasms/complications/*therapy
MH  - Palliative Care/*ethics
MH  - Patient Participation
MH  - Physician-Patient Relations/*ethics
MH  - Pneumonia, Aspiration/etiology/*prevention & control
MH  - Speech Disorders/etiology/*prevention & control
MH  - Survivors
OTO - NOTNLM
OT  - Ethics
OT  - communication
OT  - head and neck cancer
OT  - quality of life
EDAT- 2012/11/28 06:00
MHDA- 2014/03/07 06:00
CRDT- 2012/11/27 06:00
PHST- 2012/07/15 00:00 [received]
PHST- 2012/08/25 00:00 [revised]
PHST- 2012/08/27 00:00 [accepted]
PHST- 2012/11/27 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2014/03/07 06:00 [medline]
AID - S0885-3924(12)00497-6 [pii]
AID - 10.1016/j.jpainsymman.2012.08.016 [doi]
PST - ppublish
SO  - J Pain Symptom Manage. 2013 Sep;46(3):452-5. doi:
      10.1016/j.jpainsymman.2012.08.016. Epub 2012 Nov 22.


PMID- 23177555
OWN - NLM
STAT- MEDLINE
DCOM- 20131205
LR  - 20121126
IS  - 1695-9531 (Electronic)
IS  - 1695-4033 (Linking)
VI  - 77
IP  - 6
DP  - 2012 Dec
TI  - [Ethical reflections and recommendations for making clinical decisions in the
      care of the healthy newborn].
PG  - 413.e1-5
LID - 10.1016/j.anpedi.2012.06.001 [doi]
LID - S1695-4033(12)00303-7 [pii]
AB  - The care of healthy newborn during their stay in health centres is not usually a 
      problem and there are few conflicts in the relationship with the family.
      Conflicts may arise because the parents do not accept the care or care routines
      that health professionals provide. They believe that the newborn does not require
      testing or prophylactic measures, such as administration of vitamin K, or
      puncture to obtain a blood sample for newborn screening. This is because the
      information they have is not adequate, or because they reject some measures as
      they are invasive and that from their point of view, do not correspond to the
      care of a healthy newborn. This document seeks to reconcile the values of family 
      and participation in the care of their child, the rights of the newborn, and the 
      values of health professionals. It is based on adequate information, a good
      clinical relationship, and discussion in case of discrepancies that can lead to
      changes in some procedures that are not essential in the care of the newborn.
CI  - Copyright (c) 2012 Asociacion Espanola de Pediatria. Published by Elsevier
      Espana. All rights reserved.
FAU - Sanchez Escartin, M C
AU  - Sanchez Escartin MC
AD  - Unidad Neonatal, Hospital de Cruces, Barakaldo, Vizcaya, Espana.
FAU - Lopez de Heredia Goya, J
AU  - Lopez de Heredia Goya J
FAU - Aguayo Maldonado, M J
AU  - Aguayo Maldonado MJ
FAU - Blanco Bravo, D
AU  - Blanco Bravo D
FAU - Molina Morales, V
AU  - Molina Morales V
CN  - Grupo de Trabajo de Etica de la Sociedad Espanola de Neonatologia
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Practice Guideline
TT  - Reflexiones eticas y recomendaciones para la toma de decisiones clinicas en la
      atencion al recien nacido sano.
DEP - 20120720
PL  - Spain
TA  - An Pediatr (Barc)
JT  - Anales de pediatria (Barcelona, Spain : 2003)
JID - 101162596
SB  - IM
MH  - Algorithms
MH  - Humans
MH  - Infant Care/*ethics
MH  - Infant, Newborn
EDAT- 2012/11/28 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/11/27 06:00
PHST- 2012/05/15 00:00 [received]
PHST- 2012/05/31 00:00 [revised]
PHST- 2012/06/04 00:00 [accepted]
PHST- 2012/11/27 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - S1695-4033(12)00303-7 [pii]
AID - 10.1016/j.anpedi.2012.06.001 [doi]
PST - ppublish
SO  - An Pediatr (Barc). 2012 Dec;77(6):413.e1-5. doi: 10.1016/j.anpedi.2012.06.001.
      Epub 2012 Jul 20.


PMID- 23176901
OWN - NLM
STAT- MEDLINE
DCOM- 20130129
LR  - 20121126
IS  - 1552-6259 (Electronic)
IS  - 0003-4975 (Linking)
VI  - 94
IP  - 6
DP  - 2012 Dec
TI  - Transcatheter aortic valve replacement: clinical aspects and ethical
      considerations.
PG  - 1791-5
LID - 10.1016/j.athoracsur.2012.09.047 [doi]
LID - S0003-4975(12)02137-6 [pii]
FAU - Stone, Matthew L
AU  - Stone ML
AD  - Division of Thoracic and Cardiovascular Surgery, Department of Surgery,
      University of Virginia Health System, Charlottesville, Virginia, USA.
FAU - Kern, John A
AU  - Kern JA
FAU - Sade, Robert M
AU  - Sade RM
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Ann Thorac Surg
JT  - The Annals of thoracic surgery
JID - 15030100R
SB  - IM
MH  - Aortic Valve Stenosis/psychology/*surgery
MH  - Cardiac Catheterization/*ethics
MH  - *Ethics, Medical
MH  - Heart Valve Prosthesis Implantation/*ethics/methods
MH  - Humans
MH  - Prognosis
EDAT- 2012/11/28 06:00
MHDA- 2013/01/30 06:00
CRDT- 2012/11/27 06:00
PHST- 2012/07/30 00:00 [received]
PHST- 2012/09/12 00:00 [revised]
PHST- 2012/09/17 00:00 [accepted]
PHST- 2012/11/27 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/01/30 06:00 [medline]
AID - S0003-4975(12)02137-6 [pii]
AID - 10.1016/j.athoracsur.2012.09.047 [doi]
PST - ppublish
SO  - Ann Thorac Surg. 2012 Dec;94(6):1791-5. doi: 10.1016/j.athoracsur.2012.09.047.


PMID- 23176884
OWN - NLM
STAT- MEDLINE
DCOM- 20130424
LR  - 20121126
IS  - 1534-4436 (Electronic)
IS  - 1081-1206 (Linking)
VI  - 109
IP  - 6
DP  - 2012 Dec
TI  - Evaluation and validation of a bee venom sting challenge performed by a
      micro-syringe.
PG  - 438-41
LID - 10.1016/j.anai.2012.09.003 [doi]
LID - S1081-1206(12)00669-2 [pii]
AB  - BACKGROUND: The honeybee sting challenge is considered a reliable procedure to
      evaluate the efficacy of specific immunotherapy, but it is difficult and
      unpractical to perform in clinical practice, because live insects are required.
      OBJECTIVE: To assess the feasibility and reliability of a challenge test using a 
      micro-syringe, and compared the procedure with sting challenge. METHODS: Patients
      on bee venom immunotherapy and without systemic reactions at field sting were
      enrolled. They underwent a sting challenge with live bee, and large local
      reactions were assessed up to 48 hours. Those patients displaying systemic
      reactions at the sting challenge were excluded from the syringe challenge for
      ethical reasons. The syringe challenge was done by injecting 0.5 muL fresh
      unfiltered bee venom at 2 mm depth (the length of the sting left by a bee). The
      same follow-up as at the first challenge was performed. Bee-specific
      immunoglobulin E (IgE) and tryptase were measured after each challenge. RESULTS: 
      Nineteen patients underwent the sting challenge with live bees. Four had
      immediate systemic reactions (urticaria or asthma) and were excluded from the
      second challenge. The remaining 15 patients with large local reaction underwent
      the syringe challenge. No significant difference was seen in the maximum area of 
      the large local reactions between the challenge with live bees and the syringe
      challenge. Also, no change was seen in tryptase and specific antibodies.
      CONCLUSION: This preliminary study suggests that the micro-syringe challenge with
      honeybee venom is feasible and produces results indistinguishable from those of
      the traditional sting challenge.
CI  - Copyright (c) 2012 American College of Allergy, Asthma & Immunology. Published by
      Elsevier Inc. All rights reserved.
FAU - Cortellini, Gabriele
AU  - Cortellini G
AD  - Internal Medicine and Rheumatology, Rimini Hospital, Italy.
FAU - Severino, Maurizio
AU  - Severino M
FAU - Francescato, Elisabetta
AU  - Francescato E
FAU - Turillazzi, Stefano
AU  - Turillazzi S
FAU - Spadolini, Igino
AU  - Spadolini I
FAU - Rogkakou, Anthi
AU  - Rogkakou A
FAU - Passalacqua, Giovanni
AU  - Passalacqua G
LA  - eng
PT  - Journal Article
DEP - 20121010
PL  - United States
TA  - Ann Allergy Asthma Immunol
JT  - Annals of allergy, asthma & immunology : official publication of the American
      College of Allergy, Asthma, & Immunology
JID - 9503580
RN  - 0 (Bee Venoms)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 3.4.21.59 (Tryptases)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Animals
MH  - Bee Venoms/*administration & dosage/adverse effects/*immunology
MH  - Bees
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/immunology
MH  - Immunotherapy/methods
MH  - Insect Bites and Stings/*immunology
MH  - Male
MH  - Middle Aged
MH  - *Syringes
MH  - Tryptases/immunology
EDAT- 2012/11/28 06:00
MHDA- 2013/04/25 06:00
CRDT- 2012/11/27 06:00
PHST- 2012/07/13 00:00 [received]
PHST- 2012/09/05 00:00 [revised]
PHST- 2012/09/05 00:00 [accepted]
PHST- 2012/11/27 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/04/25 06:00 [medline]
AID - S1081-1206(12)00669-2 [pii]
AID - 10.1016/j.anai.2012.09.003 [doi]
PST - ppublish
SO  - Ann Allergy Asthma Immunol. 2012 Dec;109(6):438-41. doi:
      10.1016/j.anai.2012.09.003. Epub 2012 Oct 10.


PMID- 23176802
OWN - NLM
STAT- MEDLINE
DCOM- 20130124
LR  - 20220317
IS  - 1474-547X (Electronic)
IS  - 0140-6736 (Linking)
VI  - 381
IP  - 9860
DP  - 2013 Jan 5
TI  - A healthy nation: strengthening child health research in the UK.
PG  - 73-87
LID - 10.1016/S0140-6736(12)61818-2 [doi]
LID - S0140-6736(12)61818-2 [pii]
AB  - Despite a general acknowledgment that research in children is necessary and
      ethical, the evidence base for child-specific treatments is still sparse. We
      investigated children's biomedical and health services research in the UK in
      relation to training, infrastructure and activity, research evidence, and
      visibility. We show that excellent opportunities for career researchers exist
      through a competitive, national integrated academic training programme, but that 
      the number of academic paediatricians has decreased by 18% between 2000 and 2011,
      falling from 11.3% to 5.9% of the consultant workforce. The potential for rapid
      delivery of studies in children through the National Health Service (NHS) is not 
      being realised: clinical trainees are poorly equipped with core research skills; 
      most newly appointed consultant paediatricians have little or no research
      experience; less than 5% of contracted consultant time supports research; less
      than 2.5% of the 2 million children seen in the NHS every year are recruited to
      studies; and ten of the 20 UK children's hospitals do not have a clinical
      research facility. Support through National Institute for Health Research
      networks is good for studies into drugs, but inconsistent for non-drug research; 
      less than 5% of registered studies involve children and only one children's
      biomedical research centre has been allocated funding from 2012. Of the UK annual
      public and charitable biomedical research expenditure of roughly pound2.2
      billion, about 5% is directed at child health research. The scant evidence base
      is impeding the development of clinical guidance and policy-less than 20% of the 
      outputs of the National Institute for Health and Clinical Excellence are
      applicable to children. Paediatric representation on major research boards is
      weak. Parent and young people's advocacy is fragmented, and their views are
      insufficiently heeded by regulatory bodies. The strong UK Government commitment
      to biomedical research has not been translated fully to research for children.
      The power of research in children to turn the tide of the growing burden of
      non-communicable, chronic, adult diseases that have their origins in early life, 
      to benefit the health of an ageing population and future generations, and to
      reduce health-care costs is inadequately recognised. On the basis of our
      findings, we make several recommendations to improve early-years research,
      including the formation of multidisciplinary, cross-institutional groups of
      clinical and non-clinical child health researchers and their access to diagnostic
      and laboratory facilities suitable for children; a unified Children's Research
      Network for drug studies and non-drug studies; regulatory assessment of research 
      that is proportionate and based on consistent national criteria; an expansion of 
      research posts; support for parents' and young people's advocacy; collaboration
      between children's research charities; improved research training for paediatric 
      trainees; and closer integration of child health research with core NHS
      activities.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Modi, Neena
AU  - Modi N
AD  - Imperial College London, Chelsea and Westminster Hospital, London, UK.
      n.modi@imperial.ac.uk
FAU - Clark, Howard
AU  - Clark H
FAU - Wolfe, Ingrid
AU  - Wolfe I
FAU - Costello, Anthony
AU  - Costello A
FAU - Budge, Helen
AU  - Budge H
CN  - writing group of the Royal College of Paediatrics and Child Health Commission on 
      Child Health Research
FAU - Goodier, R
AU  - Goodier R
FAU - Hyde, M J
AU  - Hyde MJ
FAU - Lumsden, D
AU  - Lumsden D
FAU - Prayle, A
AU  - Prayle A
FAU - Roland, D
AU  - Roland D
LA  - eng
GR  - DRF-2009-02-112/DH_/Department of Health/United Kingdom
PT  - Journal Article
DEP - 20121120
PL  - England
TA  - Lancet
JT  - Lancet (London, England)
JID - 2985213R
SB  - IM
MH  - *Biomedical Research
MH  - Child
MH  - *Child Welfare
MH  - *Health Services Research
MH  - Humans
MH  - Research Support as Topic
MH  - United Kingdom
EDAT- 2012/11/28 06:00
MHDA- 2013/01/25 06:00
CRDT- 2012/11/27 06:00
PHST- 2012/11/27 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/01/25 06:00 [medline]
AID - S0140-6736(12)61818-2 [pii]
AID - 10.1016/S0140-6736(12)61818-2 [doi]
PST - ppublish
SO  - Lancet. 2013 Jan 5;381(9860):73-87. doi: 10.1016/S0140-6736(12)61818-2. Epub 2012
      Nov 20.


PMID- 23176355
OWN - NLM
STAT- MEDLINE
DCOM- 20130527
LR  - 20141120
IS  - 1939-3938 (Electronic)
IS  - 1556-3693 (Linking)
VI  - 8
IP  - 4
DP  - 2012 Dec
TI  - Veracity for children in pediatric forensics.
PG  - 155-62
LID - 10.1111/j.1939-3938.2012.01143.x [doi]
AB  - Child sexual abuse is a heinous crime, and school-age children are the age group 
      most commonly victimized. When occurring within the family, it is particularly
      difficult and confusing for the child to disclose. The role of the sexual assault
      nurse examiner, and the challenges in applying the ethical concept of veracity
      when caring for these young victims is examined, using vignettes based on actual 
      situations. It is essential for the forensic nurse to be able to understand and
      apply theories of childhood development to these cases in order to facilitate
      communication with the child, while providing assurance that they are believed.
CI  - (c) 2012 International Association of Forensic Nurses.
FAU - Morris, Kristen
AU  - Morris K
AD  - University of Saint Francis, Department of Nursing, Fort Wayne, IN 46808, USA.
      kmorris@sf.edu
FAU - Ditton, Michelle
AU  - Ditton M
LA  - eng
PT  - Journal Article
DEP - 20120619
PL  - United States
TA  - J Forensic Nurs
JT  - Journal of forensic nursing
JID - 101234500
SB  - IM
MH  - Child
MH  - Child Abuse, Sexual/*diagnosis
MH  - Child Development
MH  - Communication
MH  - *Forensic Nursing
MH  - Humans
MH  - *Nurse's Role
MH  - Nurse-Patient Relations
MH  - Nursing Assessment/ethics/*methods
MH  - Physical Examination
MH  - Psychological Theory
MH  - Psychology, Child
MH  - Self Disclosure
EDAT- 2012/11/28 06:00
MHDA- 2013/05/29 06:00
CRDT- 2012/11/27 06:00
PHST- 2012/11/27 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/05/29 06:00 [medline]
AID - 10.1111/j.1939-3938.2012.01143.x [doi]
PST - ppublish
SO  - J Forensic Nurs. 2012 Dec;8(4):155-62. doi: 10.1111/j.1939-3938.2012.01143.x.
      Epub 2012 Jun 19.


PMID- 23160505
OWN - NLM
STAT- MEDLINE
DCOM- 20130531
LR  - 20151119
IS  - 1720-8319 (Electronic)
IS  - 1594-0667 (Linking)
VI  - 24
IP  - 3 Suppl
DP  - 2012 Jun
TI  - Discussing end-of-life care issues with terminally ill patients and their
      relatives: comparisons among physicians, nurses and psychologists.
PG  - 35-42
AB  - BACKGROUND AND AIMS: The aim of this study was to analyse the end-of-life topics 
      most frequently discussed by Italian physicians, nurses and psychologists with
      terminally ill patients and their relatives. Findings were compared with the
      levels of communication reported by physicians in other countries involved in the
      EURELD research project, in Europe and elsewhere. METHODS: An ad hoc
      questionnaire was prepared to measure levels of communication and administered to
      716 professionals (181 physicians, 454 nurses and 81 psychologists) employed in
      geriatric hospital wards, hospices and nursing homes, or registered with
      professional associations in the Veneto and Trentino Alto-Adige regions of
      north-east Italy. Statistical analyses (frequency analysis, multivariate logistic
      regression) were conducted on data from questionnaires returned by standard mail 
      or email. RESULTS: Communication levels vary for the various end-of-life issues
      which physicians, nurses and psychologists are required to discuss and the
      individuals with whom they deal. Italian physicians are more communicative with
      relatives than with patients, whereas psychologists tend to discuss these
      problems more with patients than with members of their families. Nurses behave in
      much the same way with both patients and relatives. By comparison with their
      colleagues elsewhere in Europe, Italian physicians reveal more evident
      differences in their willingness to discuss end-of-life issues, depending on
      whether they are communicating with patients or relatives. Having received
      bio-ethical training helps physicians communicate with their patients.
      CONCLUSIONS: Communicating is a fundamental part of providing care for terminally
      ill patients and support for their families. The patient care process involves
      several kinds of professionals, who are all increasingly called upon to be
      prepared to discuss the end of a patient's life, and to develop a therapeutic
      relationship which includes communicating without evading any of the aspects (and
      problems) relating to this crucial final stage of an individual's life.
FAU - Iasevoli, Mario
AU  - Iasevoli M
AD  - Geriatrics Division, University of Padova, Via Giustiniani 2, 35128 Padova,
      Italy.
FAU - Giantin, Valter
AU  - Giantin V
FAU - Voci, Alberto
AU  - Voci A
FAU - Valentini, Elisabetta
AU  - Valentini E
FAU - Zurlo, Anna
AU  - Zurlo A
FAU - Maggi, Stefania
AU  - Maggi S
FAU - Siviero, Paola
AU  - Siviero P
FAU - Orru, Graziella
AU  - Orru G
FAU - Crepaldi, Gaetano
AU  - Crepaldi G
FAU - Pegoraro, Renzo
AU  - Pegoraro R
FAU - Manzato, Enzo
AU  - Manzato E
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Aging Clin Exp Res
JT  - Aging clinical and experimental research
JID - 101132995
SB  - IM
MH  - Attitude of Health Personnel
MH  - Attitude to Death
MH  - *Communication
MH  - Family/*psychology
MH  - Humans
MH  - Italy
MH  - Nurse's Role/psychology
MH  - Nurse-Patient Relations
MH  - Nurses/*psychology
MH  - Physician's Role/psychology
MH  - Physician-Patient Relations
MH  - Physicians/*psychology
MH  - *Psychology
MH  - Surveys and Questionnaires
MH  - Terminal Care/*psychology
MH  - Terminally Ill/*psychology
EDAT- 2012/11/28 06:00
MHDA- 2013/06/01 06:00
CRDT- 2012/11/20 06:00
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/06/01 06:00 [medline]
AID - 8712 [pii]
PST - ppublish
SO  - Aging Clin Exp Res. 2012 Jun;24(3 Suppl):35-42.


PMID- 22945192
OWN - NLM
STAT- MEDLINE
DCOM- 20130410
LR  - 20171116
IS  - 0353-5053 (Print)
IS  - 0353-5053 (Linking)
VI  - 24 Suppl 1
DP  - 2012 Sep
TI  - An exploration of how film portrays psychopathology: the animated documentary
      film Waltz with Bashir, the depiction of PTSD and cultural perceptions.
PG  - S70-6
AB  - With the inauguration of the UK's first ever Medical Film festival MedFest in
      2011 there has been resurgence in the interest of the association between
      psychiatry and film. The festival in 2012 was titled "HealthScreen":
      Understanding Illness through Film and its aim, according to the founder Dr
      Kamran Ahmed, was, 'To stimulate debate of the social, political and ethical
      implications of portrayals of health and illness on our screens' (1). Waltz with 
      Bashir is a 2008 Israeli animated documentary film written and directed by Ari
      Folman. It portrays the protagonist (Folman) in search of his lost memories of
      his experience as a soldier in the 1982 Lebanon War and his attempt to both
      decipher them and reconcile himself with them. 2012 marks the 30th year
      commemoration of the Sabra and Shatilla tragedies. Waltz with Bashir vividly
      depicts the massacres of Palestinians in the Sabra and Shatilla refugee camps in 
      Beirut through the lens of an ex-IDF serviceman and the harrowing effects that
      PTSD has on him. Waltz with Bashir was nominated for an Academy Award for Best
      Foreign Language Film however despite the popularity of the film and much
      critical acclaim it is officially banned in Lebanon. The authors are mindful of
      the devastating effects that the atrocities have had on the mental health of all 
      those who were involved, the Lebanese, Palestinians and also the Israelis. The
      purpose of this presentation is to explore how the film Waltz with Bashir
      portrays PTSD and how it has influenced cultural perceptions.
FAU - Hankir, Ahmed
AU  - Hankir A
AD  - The Royal Oldham Hospital, Oldham England, Acute Pennine NHS Trust, UK.
      ahmedzakaria@doctors.org.uk
FAU - Agius, Mark
AU  - Agius M
LA  - eng
PT  - Journal Article
PL  - Croatia
TA  - Psychiatr Danub
JT  - Psychiatria Danubina
JID - 9424753
SB  - IM
MH  - Combat Disorders/diagnosis/*psychology
MH  - *Cross-Cultural Comparison
MH  - *Documentation
MH  - Humans
MH  - Israel
MH  - Jews/*psychology
MH  - Lebanon
MH  - Male
MH  - *Motion Pictures
MH  - Psychopathology
MH  - Stress Disorders, Post-Traumatic/diagnosis/*psychology
MH  - *War Crimes
EDAT- 2012/11/28 06:00
MHDA- 2013/04/11 06:00
CRDT- 2012/09/05 06:00
PHST- 2012/09/05 06:00 [entrez]
PHST- 2012/11/28 06:00 [pubmed]
PHST- 2013/04/11 06:00 [medline]
PST - ppublish
SO  - Psychiatr Danub. 2012 Sep;24 Suppl 1:S70-6.


PMID- 28080371
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 2047-9018 (Electronic)
IS  - 0029-6570 (Linking)
VI  - 27
IP  - 13
DP  - 2012 Nov 28
TI  - News update.
PG  - 67
LID - 10.7748/ns.27.13.67.s65 [doi]
AB  - The RCN has raised concerns that many healthcare assistants are paid less than
      the ethical minimum. While the current UK-wide minimum wage is pound6.19 per
      hour, the Living Wage Foundation - which campaigns for minimum wages that refl
      ect the cost of living - claims the minimum wage should be pound8.30 per hour in 
      London and pound7.20 per hour in other parts of UK. Commenting during the recent 
      Living Wage Week, RCN general secretary Peter Carter said: 'This affects college 
      members, particularly healthcare assistants in the private sector, who are often 
      paid less than the living wage. Some struggle to make ends meet, forcing them to 
      claim benefi ts.'
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Stand
JT  - Nursing standard (Royal College of Nursing (Great Britain) : 1987)
JID - 9012906
EDAT- 2012/11/28 00:00
MHDA- 2012/11/28 00:01
CRDT- 2017/01/13 06:00
PHST- 2017/01/13 06:00 [entrez]
PHST- 2012/11/28 00:00 [pubmed]
PHST- 2012/11/28 00:01 [medline]
AID - 10.7748/ns.27.13.67.s65 [doi]
PST - ppublish
SO  - Nurs Stand. 2012 Nov 28;27(13):67. doi: 10.7748/ns.27.13.67.s65.


PMID- 23175738
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130207
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 6
DP  - 2012
TI  - A randomised clinical trial of comprehensive cardiac rehabilitation versus usual 
      care for patients treated for infective endocarditis--the CopenHeartIE trial
      protocol.
LID - 10.1136/bmjopen-2012-001929 [doi]
LID - e001929 [pii]
AB  - INTRODUCTION: Infective endocarditis (IE) is among the most serious infectious
      diseases in the western world. Treatment requires lengthy hospitalisation,
      high-dosage antibiotic therapy and possible valve replacement surgery. Despite
      advances in treatment, the 1-year mortality remains at 20-40%. Studies indicate
      that patients experience persisting physical symptoms, diminished quality of life
      and difficulties returning to work up to a year postdischarge. No studies
      investigating the effects of rehabilitation have been published. We present the
      rationale and design of the CopenHeart(IE) trial, which investigates the effect
      of comprehensive cardiac rehabilitation versus usual care for patients treated
      for IE. METHODS AND ANALYSIS: We will conduct a randomised clinical trial to
      investigate the effects of comprehensive cardiac rehabilitation versus usual care
      on the physical and psychosocial functioning of patients treated for IE. The
      trial is a multicentre, parallel design trial with 1 : 1 individual randomisation
      to either the intervention or control group. The intervention consists of five
      psychoeducational consultations provided by specialised nurses and a 12-week
      exercise training programme. The primary outcome is mental health (MH) measured
      by the standardised Short Form 36 (SF-36). The secondary outcome is peak oxygen
      uptake measured by the bicycle ergospirometry test. Furthermore, a number of
      exploratory analyses will be performed. Based on sample size calculation, 150
      patients treated for left-sided (native or prosthetic valve) or cardiac device
      endocarditis will be included in the trial. A qualitative and a survey-based
      complementary study will be undertaken, to investigate postdischarge experiences 
      of the patients. A qualitative postintervention study will explore rehabilitation
      participation experiences. ETHICS AND DISSEMINATION: The study complies with the 
      Declaration of Helsinki and was approved by the regional research ethics
      committee (no H-1-2011-129) and the Danish Data Protection Agency (no
      2007-58-0015). Study findings will be disseminated widely through peer-reviewed
      publications and conference presentations. REGISTRATION: Clinicaltrials.gov
      identifier: NCT01512615.
FAU - Rasmussen, Trine Bernholdt
AU  - Rasmussen TB
AD  - The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen,
      Denmark.
FAU - Zwisler, Ann-Dorthe
AU  - Zwisler AD
FAU - Sibilitz, Kirstine Laerum
AU  - Sibilitz KL
FAU - Risom, Signe Stelling
AU  - Risom SS
FAU - Bundgaard, Henning
AU  - Bundgaard H
FAU - Gluud, Christian
AU  - Gluud C
FAU - Moons, Philip
AU  - Moons P
FAU - Winkel, Per
AU  - Winkel P
FAU - Thygesen, Lau Caspar
AU  - Thygesen LC
FAU - Hansen, Jane Lindschou
AU  - Hansen JL
FAU - Norekval, Tone Merete
AU  - Norekval TM
FAU - Berg, Selina Kikkenborg
AU  - Berg SK
CN  - CopenHeartIE Group
LA  - eng
SI  - ClinicalTrials.gov/NCT01512615
PT  - Journal Article
DEP - 20121121
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3533051
EDAT- 2012/11/24 06:00
MHDA- 2012/11/24 06:01
CRDT- 2012/11/24 06:00
PHST- 2012/11/24 06:00 [entrez]
PHST- 2012/11/24 06:00 [pubmed]
PHST- 2012/11/24 06:01 [medline]
AID - bmjopen-2012-001929 [pii]
AID - 10.1136/bmjopen-2012-001929 [doi]
PST - epublish
SO  - BMJ Open. 2012 Nov 21;2(6). pii: bmjopen-2012-001929. doi:
      10.1136/bmjopen-2012-001929. Print 2012.


PMID- 23175550
OWN - NLM
STAT- MEDLINE
DCOM- 20130211
LR  - 20181202
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 265
IP  - 3
DP  - 2012 Dec
TI  - The Lazarus syndrome and the ethics of evidence-based versus experience-based
      medicine.
PG  - 976; author reply 977
LID - 10.1148/radiol.12121485 [doi]
FAU - Hall, Ferris M
AU  - Hall FM
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
CON - Radiology. 2012 Jun;263(3):629-32. PMID: 22623689
MH  - Aneurysm, Ruptured/*therapy
MH  - Decision Making/*ethics
MH  - Embolization, Therapeutic/*methods
MH  - Evidence-Based Medicine/*ethics
MH  - Female
MH  - Humans
MH  - Intensive Care Units/*economics/*ethics
MH  - Intracranial Aneurysm/*therapy
MH  - Subarachnoid Hemorrhage/*therapy
EDAT- 2012/11/24 06:00
MHDA- 2013/02/12 06:00
CRDT- 2012/11/24 06:00
PHST- 2012/11/24 06:00 [entrez]
PHST- 2012/11/24 06:00 [pubmed]
PHST- 2013/02/12 06:00 [medline]
AID - 265/3/976 [pii]
AID - 10.1148/radiol.12121485 [doi]
PST - ppublish
SO  - Radiology. 2012 Dec;265(3):976; author reply 977. doi: 10.1148/radiol.12121485.


PMID- 23175543
OWN - NLM
STAT- MEDLINE
DCOM- 20130211
LR  - 20220310
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 265
IP  - 3
DP  - 2012 Dec
TI  - Hypervascular hepatocellular carcinoma: correlation between biologic features and
      signal intensity on gadoxetic acid-enhanced MR images.
PG  - 780-9
LID - 10.1148/radiol.12120226 [doi]
AB  - PURPOSE: To analyze the correlation among biologic features, tumor marker
      production, and signal intensity at gadoxetic acid-enhanced MR imaging in
      hepatocellular carcinomas (HCCs). MATERIALS AND METHODS: Institutional ethics
      committee approval and informed consent were obtained for this retrospective
      study. From April 2008 to September 2011, 180 surgically resected HCCs in 180
      patients (age, 65.0 years +/- 10.3 [range, 34-83 years]; 138 men, 42 women) were 
      classified as either hypointense (n = 158) or hyperintense (n = 22) compared with
      the signal intensity of the background liver on hepatobiliary phase gadoxetic
      acid-enhanced MR images. Pathologic features were analyzed and a fetoprotein
      (AFP) and protein induced by vitamin K absence or antagonist-II (PIVKA-II)
      production were compared by means of serum analysis and immunohistochemical
      staining. Recurrence and survival rates were also evaluated. The Mann-Whitney and
      Pearson correlation tests were used for statistical analysis. RESULTS: The grade 
      of differentiation was higher (P = .028) and portal vein invasion was less
      frequent in hyperintense HCCs (13.6%) than in hypointense HCCs (36.7%) (P =
      .039). The serum levels of AFP, Lens culinaris agglutinin reactive fraction of
      AFP, and PIVKA-II were lower in hyperintense than in hypointense HCCs (P = .003, 
      .004, and .026, respectively). Immunohistochemical AFP and PIVKA-II expression
      were lower in hyperintense than in hypointense HCCs (both P < .001). The
      recurrence rate was lower in hyperintense than in hypointense HCCs (P = .039).
      CONCLUSION: The results suggest that hyperintense HCCs on gadoxetic acid-enhanced
      MR images are less aggressive than hypointense HCCs. SUPPLEMENTAL MATERIAL:
      http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.12120226/-/DC1.
CI  - (c) RSNA, 2012.
FAU - Kitao, Azusa
AU  - Kitao A
AD  - Departments of Radiology, Gastroenterology, and Human Pathology, Kanazawa
      University Graduate School of Medical Science, 13-1 Takaramachi, Kanazawa
      920-8640, Japan. kitaoa@staff.kanazawa-u.ac.jp
FAU - Matsui, Osamu
AU  - Matsui O
FAU - Yoneda, Norihide
AU  - Yoneda N
FAU - Kozaka, Kazuto
AU  - Kozaka K
FAU - Kobayashi, Satoshi
AU  - Kobayashi S
FAU - Koda, Wataru
AU  - Koda W
FAU - Gabata, Toshifumi
AU  - Gabata T
FAU - Yamashita, Tatsuya
AU  - Yamashita T
FAU - Kaneko, Shuichi
AU  - Kaneko S
FAU - Nakanuma, Yasuni
AU  - Nakanuma Y
FAU - Kita, Ryuichi
AU  - Kita R
FAU - Arii, Shigeki
AU  - Arii S
LA  - eng
GR  - UL1 RR025758/RR/NCRR NIH HHS/United States
GR  - 1 UL1 RR 025758-01/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Biomarkers)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Contrast Media)
RN  - 0 (Organic Anion Transporters, Sodium-Independent)
RN  - 0 (Protein Precursors)
RN  - 0 (SLCO1B3 protein, human)
RN  - 0 (Solute Carrier Organic Anion Transporter Family Member 1B3)
RN  - 0 (alpha-Fetoproteins)
RN  - 0 (gadolinium ethoxybenzyl DTPA)
RN  - 53230-14-1 (acarboxyprothrombin)
RN  - 9001-26-7 (Prothrombin)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/metabolism
MH  - Biomarkers, Tumor/metabolism
MH  - Carcinoma, Hepatocellular/blood supply/metabolism/*pathology
MH  - Contrast Media
MH  - Female
MH  - Gadolinium DTPA
MH  - Humans
MH  - Immunohistochemistry
MH  - Liver Neoplasms/blood supply/metabolism/*pathology
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Invasiveness/diagnosis
MH  - Neoplasm Recurrence, Local/diagnosis
MH  - Organic Anion Transporters, Sodium-Independent/metabolism
MH  - Protein Precursors/metabolism
MH  - Prothrombin/metabolism
MH  - Retrospective Studies
MH  - Solute Carrier Organic Anion Transporter Family Member 1B3
MH  - Survival Rate
MH  - alpha-Fetoproteins/metabolism
PMC - PMC5375624
EDAT- 2012/11/24 06:00
MHDA- 2013/02/12 06:00
CRDT- 2012/11/24 06:00
PHST- 2012/11/24 06:00 [entrez]
PHST- 2012/11/24 06:00 [pubmed]
PHST- 2013/02/12 06:00 [medline]
AID - 265/3/780 [pii]
AID - 10.1148/radiol.12120226 [doi]
PST - ppublish
SO  - Radiology. 2012 Dec;265(3):780-9. doi: 10.1148/radiol.12120226.


PMID- 23175460
OWN - NLM
STAT- MEDLINE
DCOM- 20130812
LR  - 20181202
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 6
DP  - 2013 Jun
TI  - Can phase I cancer research studies in children be justified on ethical grounds?
PG  - 407
LID - 10.1136/medethics-2012-101125 [doi]
FAU - Ekert, Henry
AU  - Ekert H
AD  - ekerthenry@optushome.com.au
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20121122
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
CON - J Med Ethics. 2013 Jun;39(6):403-6. PMID: 23118468
MH  - Clinical Trials, Phase I as Topic/*ethics
MH  - *Decision Making
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Neoplasms/*therapy
MH  - *Personal Autonomy
MH  - Research Personnel/*ethics
MH  - *Therapeutic Misconception
OTO - NOTNLM
OT  - Children
OT  - Clinical Ethics
OT  - Research Ethics
OT  - Research on Special Populations
EDAT- 2012/11/24 06:00
MHDA- 2013/08/13 06:00
CRDT- 2012/11/24 06:00
PHST- 2012/11/24 06:00 [entrez]
PHST- 2012/11/24 06:00 [pubmed]
PHST- 2013/08/13 06:00 [medline]
AID - medethics-2012-101125 [pii]
AID - 10.1136/medethics-2012-101125 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Jun;39(6):407. doi: 10.1136/medethics-2012-101125. Epub 2012
      Nov 22.


PMID- 23175459
OWN - NLM
STAT- MEDLINE
DCOM- 20130527
LR  - 20191210
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 4
DP  - 2013 Apr
TI  - Ethics of medical care and clinical research: a qualitative study of principal
      investigators in biomedical HIV prevention research.
PG  - 231-5
LID - 10.1136/medethics-2012-100936 [doi]
AB  - In clinical research there is a tension between the role of a doctor, who must
      serve the best interests of the patient, and the role of the researcher, who must
      produce knowledge that may not have any immediate benefits for the research
      participant. This tension is exacerbated in HIV research in low and middle income
      countries, which frequently uncovers comorbidities other than the condition under
      study. Some bioethicists argue that as the goals of medicine and those of
      research are distinct, it is a mistake for researchers to assume therapeutic
      responsibilities while engaging in research. Others propose that there is a duty 
      of care, but disagree as to how this is limited and specified. In this
      qualitative study, principal investigators from HIV prevention trials discuss
      their experience of providing medical benefits to participants within the context
      of conducting research into HIV biomedical prevention technologies. They describe
      the limitations imposed at times by funders and at times by infrastructure
      constraints, and canvass the importance of ancillary care provision and capacity 
      building in trial communities. The views of the principal investigators are
      compatible with the perspective that there is a duty of care, limited by the
      nature of the research, the depth of the relationship between research and
      participant, and the capacity of the research site. The therapeutic orientation
      in HIV prevention trial appears to be indivisible from competent research
      practise by making concrete and appropriate benefits available to trial
      participants and their communities that support rather than compete with local
      infrastructure.
FAU - Haire, Bridget G
AU  - Haire BG
AD  - Centre for Values, Ethics and the Law in Medicine, University of Sydney, Medical 
      Foundation Building, Parramatta Road, Camperdown, Sydney, NSW 2050, Australia.
      bridget.haire@sydney.edu.au
LA  - eng
PT  - Journal Article
DEP - 20121122
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Clinical Trials as Topic/*ethics
MH  - Conflict of Interest
MH  - *Conflict, Psychological
MH  - HIV Infections/drug therapy/*prevention & control
MH  - Humans
MH  - Patient-Centered Care/*ethics
MH  - *Physician's Role
MH  - Physician-Patient Relations/*ethics
MH  - Research Design
MH  - Research Personnel/*ethics
MH  - Researcher-Subject Relations/*ethics
MH  - Risk
EDAT- 2012/11/24 06:00
MHDA- 2013/05/29 06:00
CRDT- 2012/11/24 06:00
PHST- 2012/11/24 06:00 [entrez]
PHST- 2012/11/24 06:00 [pubmed]
PHST- 2013/05/29 06:00 [medline]
AID - medethics-2012-100936 [pii]
AID - 10.1136/medethics-2012-100936 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Apr;39(4):231-5. doi: 10.1136/medethics-2012-100936. Epub 2012
      Nov 22.


PMID- 23175170
OWN - NLM
STAT- MEDLINE
DCOM- 20140403
LR  - 20130515
IS  - 1552-5724 (Electronic)
IS  - 0898-0101 (Linking)
VI  - 31
IP  - 2
DP  - 2013 Jun
TI  - Knowing, caring, and telehealth technology: "going the distance" in nursing
      practice.
PG  - 104-12
LID - 10.1177/0898010112465357 [doi]
AB  - The use of technology in delivery of health care services is rapidly increasing, 
      and more nurses are using telehealth to provide care by distance to persons with 
      complex health challenges. The rapid uptake of telehealth modalities and dynamic 
      evolution of technologies has outpaced the generation of empirical knowledge to
      support nursing practice in this emerging field, specifically in relation to how 
      nurses come to know the person and engage in holistic care in a virtual
      environment. Knowing the person and nursing care have historically been
      associated with physical presence and close proximity in the nurse-client
      relationship, and the use of telehealth can limit the ways in which a nurse can
      observe the person, potentiate perceptions of distance, and lead to a
      reductionist perspective in care. The purpose of this article is to illuminate
      the dynamic and evolving nature of nursing practice in relation to the use of
      telehealth and to highlight gaps in nursing knowledge specific to knowing the
      person in a virtual environment. Such an understanding is necessary to inform
      future research and generate empirical evidence to support nurses in providing
      ethical, safe, effective, and holistic care by distance to persons through
      telehealth technology.
FAU - Nagel, Daniel A
AU  - Nagel DA
AD  - School of Nursing, Faculty of Medicine, Wilson Hall, 3506 University Street,
      McGill University, Montreal, Quebec, Canada H3A 2A7. daniel.nagel@mail.mcgill.ca
FAU - Pomerleau, Sophie G
AU  - Pomerleau SG
FAU - Penner, Jamie L
AU  - Penner JL
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121121
PL  - United States
TA  - J Holist Nurs
JT  - Journal of holistic nursing : official journal of the American Holistic Nurses'
      Association
JID - 8506709
MH  - *Empathy
MH  - *Holistic Nursing
MH  - Humans
MH  - *Nurse-Patient Relations
MH  - *Telenursing
OTO - NOTNLM
OT  - health care delivery
OT  - holistic
OT  - knowing
OT  - nursing care
OT  - technology
OT  - telehealth
EDAT- 2012/11/24 06:00
MHDA- 2014/04/04 06:00
CRDT- 2012/11/24 06:00
PHST- 2012/11/24 06:00 [entrez]
PHST- 2012/11/24 06:00 [pubmed]
PHST- 2014/04/04 06:00 [medline]
AID - 0898010112465357 [pii]
AID - 10.1177/0898010112465357 [doi]
PST - ppublish
SO  - J Holist Nurs. 2013 Jun;31(2):104-12. doi: 10.1177/0898010112465357. Epub 2012
      Nov 21.


PMID- 23175025
OWN - NLM
STAT- MEDLINE
DCOM- 20130517
LR  - 20121123
IS  - 1573-6741 (Electronic)
IS  - 0002-9548 (Linking)
VI  - 72
IP  - 4
DP  - 2012 Dec
TI  - Rankian will.
PG  - 320-5
LID - 10.1057/ajp.2012.20 [doi]
AB  - Otto Rank (1884-1939) served as Freud's closest partner in the psychoanalytic
      movement from 1906 to 1926. From 1923 on, Rank, initially with Ferenczi, focused 
      on making analysis more therapeutic, emphasizing current experience in the
      session over historical exploration and interpretation. Rank settled on will as a
      missing factor, and wrote extensively about it after the break with Freud in
      1926, when he moved to Paris. He emphasized the here-and-now, redefined
      "resistance" as a positive aspect of counter-will, and suggested a time limit for
      analysis. Ousted from analytic circles in 1930, he eventually moved to New York, 
      continuing to treat patients and teach until his unexpected death at 55 in 1939. 
      After decades of obscurity, Rank has gained readers and therapists whose
      orientation is interpersonal, client-centered, relational, humanistic, or
      existential. His influence on post-Freudian ego-psychology is finally being
      acknowledged as are his ideas about creativity, will, life-fear and death-fear,
      guilt, and ethics.
FAU - Lieberman, E James
AU  - Lieberman EJ
AD  - George Washington University, School of Medicine, USA. ejl@gwu.edu
LA  - eng
PT  - Biography
PT  - Historical Article
PT  - Journal Article
PL  - England
TA  - Am J Psychoanal
JT  - American journal of psychoanalysis
JID - 0372630
SB  - IM
MH  - Freudian Theory/history
MH  - History, 20th Century
MH  - Psychoanalysis/*history
MH  - Psychoanalytic Theory
MH  - Psychoanalytic Therapy
MH  - Volition
PS  - Rank O
FPS - Rank, Otto
EDAT- 2012/11/24 06:00
MHDA- 2013/05/18 06:00
CRDT- 2012/11/24 06:00
PHST- 2012/11/24 06:00 [entrez]
PHST- 2012/11/24 06:00 [pubmed]
PHST- 2013/05/18 06:00 [medline]
AID - ajp201220 [pii]
AID - 10.1057/ajp.2012.20 [doi]
PST - ppublish
SO  - Am J Psychoanal. 2012 Dec;72(4):320-5. doi: 10.1057/ajp.2012.20.


PMID- 23174801
OWN - NLM
STAT- MEDLINE
DCOM- 20131022
LR  - 20220210
IS  - 1530-0366 (Electronic)
IS  - 1098-3600 (Linking)
VI  - 15
IP  - 5
DP  - 2013 May
TI  - "Trust is not something you can reclaim easily": patenting in the field of
      direct-to-consumer genetic testing.
PG  - 382-7
LID - 10.1038/gim.2012.143 [doi]
AB  - PURPOSE: Recently, 23andMe announced that it had obtained its first patent,
      related to "polymorphisms associated with Parkinson's disease" (US-B-8187811).
      This announcement immediately sparked controversy in the community of 23andMe
      users and research participants, especially with regard to issues of transparency
      and trust. The purpose of this article was to analyze the patent portfolio of
      this prominent direct-to-consumer genetic testing company and discuss the
      potential ethical implications of patenting in this field for public
      participation in Web-based genetic research. METHODS: We searched the publicly
      accessible patent database Espacenet as well as the commercially available
      database Micropatent for published patents and patent applications of 23andMe.
      RESULTS: Six patent families were identified for 23andMe. These included patent
      applications related to: genetic comparisons between grandparents and
      grandchildren, family inheritance, genome sharing, processing data from
      genotyping chips, gamete donor selection based on genetic calculations, finding
      relatives in a database, and polymorphisms associated with Parkinson disease.
      CONCLUSION: An important lesson to be drawn from this ongoing controversy seems
      to be that any (private or public) organization involved in research that relies 
      on human participation, whether by providing information, body material, or both,
      needs to be transparent, not only about its research goals but also about its
      strategies and policies regarding commercialization.
FAU - Sterckx, Sigrid
AU  - Sterckx S
AD  - Bioethics Institute Ghent, Universiteit Gent, Gent, Belgium.
FAU - Cockbain, Julian
AU  - Cockbain J
FAU - Howard, Heidi
AU  - Howard H
FAU - Huys, Isabelle
AU  - Huys I
FAU - Borry, Pascal
AU  - Borry P
LA  - eng
PT  - Journal Article
DEP - 20121122
PL  - United States
TA  - Genet Med
JT  - Genetics in medicine : official journal of the American College of Medical
      Genetics
JID - 9815831
SB  - IM
MH  - Databases, Factual
MH  - Genetic Research/ethics/legislation & jurisprudence
MH  - *Genetic Testing/ethics/legislation & jurisprudence
MH  - Health Care Sector/ethics/legislation & jurisprudence
MH  - Humans
MH  - *Intellectual Property
MH  - Internet
MH  - *Trust
EDAT- 2012/11/24 06:00
MHDA- 2013/10/23 06:00
CRDT- 2012/11/24 06:00
PHST- 2012/11/24 06:00 [entrez]
PHST- 2012/11/24 06:00 [pubmed]
PHST- 2013/10/23 06:00 [medline]
AID - S1098-3600(21)02033-5 [pii]
AID - 10.1038/gim.2012.143 [doi]
PST - ppublish
SO  - Genet Med. 2013 May;15(5):382-7. doi: 10.1038/gim.2012.143. Epub 2012 Nov 22.


PMID- 23174794
OWN - NLM
STAT- MEDLINE
DCOM- 20131205
LR  - 20191112
IS  - 1809-4546 (Electronic)
IS  - 0100-6991 (Linking)
VI  - 39
IP  - 5
DP  - 2012 Sep-Oct
TI  - [Rational use of animal models for research and microsurgery training].
PG  - 414-7
LID - S0100-69912012000500013 [pii]
AB  - The objective of this study is to disclose an experimental model of low cost,
      which complies with the regulatory norms of animal experiments by using dead
      animals from other experiments, contributing to the improvement of microsurgery
      learning. Cadavers of Wistar rats, originated from disposal of other courses, are
      used. The corpses of thawed mice are used for basic microsurgical training of
      medical students at the Nove de Julho University, aiming to contribute to the
      students' training. Their use is justified by the low cost of the material used, 
      many animals being spared during the intermediate phase of skill development for 
      realization of micro-anastomoses. This experimental model is inexpensive and
      allows the rational use of animals, corroborating with the ethical standards of
      experimental research and contributing to the education and training of
      microsurgery.
FAU - Kinshoku, Marcio Rogerio
AU  - Kinshoku MR
AD  - Universidade Nove de Julho, Sao Paulo, SP, Brazil. mrkinshoku@uol.com.br
FAU - Rodriguez, Carlos Alberto Lopez
AU  - Rodriguez CA
FAU - Fidalgo, Ramiro de Souza
AU  - Fidalgo Rde S
FAU - Duran, Cinthya Cosme Gutierrez
AU  - Duran CC
FAU - Leme, Pedro Luiz Squilacci
AU  - Leme PL
FAU - Duarte, Ivone da Silva
AU  - Duarte Ida S
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Uso racional de modelos animais para pesquisa e ensino de microcirurgia.
PL  - Brazil
TA  - Rev Col Bras Cir
JT  - Revista do Colegio Brasileiro de Cirurgioes
JID - 7809515
SB  - IM
MH  - Animal Experimentation
MH  - Animals
MH  - Mice
MH  - Microsurgery/*education
MH  - *Models, Animal
MH  - Rats
MH  - Rats, Wistar
MH  - Research/*education
MH  - Research Design
EDAT- 2012/11/24 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/11/24 06:00
PHST- 2011/06/10 00:00 [received]
PHST- 2011/08/15 00:00 [accepted]
PHST- 2012/11/24 06:00 [entrez]
PHST- 2012/11/24 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - S0100-69912012000500013 [pii]
AID - 10.1590/s0100-69912012000500013 [doi]
PST - ppublish
SO  - Rev Col Bras Cir. 2012 Sep-Oct;39(5):414-7. doi: 10.1590/s0100-69912012000500013.


PMID- 23174720
OWN - NLM
STAT- MEDLINE
DCOM- 20130620
LR  - 20121123
IS  - 1998-4138 (Electronic)
IS  - 1998-4138 (Linking)
VI  - 8
IP  - 3
DP  - 2012 Jul-Sep
TI  - Clinicoepidemiological analysis of female breast cancer patients in Kashmir.
PG  - 389-93
LID - 10.4103/0973-1482.103518 [doi]
AB  - AIM: The aim of this study was to analyze the demographic features, reproductive 
      history and stage at disease presentation among the female breast cancer
      patients. DESIGN AND SETTING: The present prospective hospital-based study was
      conducted in Department of Radiation Oncology, University Teaching and Tertiary
      Referral Hospital. MATERIALS AND METHODS: After approval from the Institute's
      ethical committee, 132 female breast cancer patients surgically treated either by
      mastectomy or breast conserving surgery (BCS) and then referred to the department
      of radiation oncology for further management and/or follow-up as per the hospital
      protocol, were enrolled in the study (January 2010 to December 2011) after
      obtaining a written informed consent from the patients. The patients were
      diagnosed by histology [fine needle aspiration cytology (FNAC), true cut or
      excision biopsy], mammography and ultrasonography (USG). The patients were
      analyzed as per the demographic and reproductive history and the stage of disease
      at presentation. The data collected were expressed as percentage (%), mean,
      median and standard deviation (SD). RESULTS: The mean age at presentation was
      46.6 +/- 10.2 years. The majority of patients were from rural areas, married,
      multiparous and post-menopausal. The commonest stage at disease presentation was 
      IIb. CONCLUSION: In comparison to the rest of Indian scenario, more awareness
      related to breast cancer among post-menopausal and the rural females is needed.
      The role of peri-menopausal status, which represent 10% (n = 14) patients needs
      to be established in relation to breast cancer.
FAU - Wani, Shaqul Qamar
AU  - Wani SQ
AD  - Department of Radiation Oncology, Government Medical College and Associated
      Hospitals, Karan Nagar, Srinagar, India. drsqamar1@gmail.com
FAU - Khan, Talib
AU  - Khan T
FAU - Wani, Saiful Y
AU  - Wani SY
FAU - Koka, Abid H
AU  - Koka AH
FAU - Arshad, Syed
AU  - Arshad S
FAU - Rafiq, Liza
AU  - Rafiq L
FAU - Mqabool, Lone M
AU  - Mqabool LM
FAU - Afroz, Fir
AU  - Afroz F
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Cancer Res Ther
JT  - Journal of cancer research and therapeutics
JID - 101249598
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biopsy, Fine-Needle
MH  - Breast/*pathology/*surgery
MH  - *Breast Neoplasms/diagnosis/epidemiology/surgery
MH  - China/epidemiology
MH  - Demography
MH  - Female
MH  - Humans
MH  - Incidence
MH  - India/epidemiology
MH  - Mammography
MH  - Mastectomy, Radical
MH  - Mastectomy, Segmental
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Pakistan/epidemiology
MH  - Prognosis
MH  - Prospective Studies
MH  - Ultrasonography, Mammary
EDAT- 2012/11/24 06:00
MHDA- 2013/06/21 06:00
CRDT- 2012/11/24 06:00
PHST- 2012/11/24 06:00 [entrez]
PHST- 2012/11/24 06:00 [pubmed]
PHST- 2013/06/21 06:00 [medline]
AID - JCanResTher_2012_8_3_389_103518 [pii]
AID - 10.4103/0973-1482.103518 [doi]
PST - ppublish
SO  - J Cancer Res Ther. 2012 Jul-Sep;8(3):389-93. doi: 10.4103/0973-1482.103518.


PMID- 23174524
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130109
LR  - 20211021
IS  - 2210-2612 (Print)
IS  - 2210-2612 (Linking)
VI  - 4
IP  - 1
DP  - 2013
TI  - An elective combined caesarean section and small bowel GIST resection during the 
      third trimester of pregnancy: Report of a case.
PG  - 121-4
LID - 10.1016/j.ijscr.2012.10.017 [doi]
LID - S2210-2612(12)00200-3 [pii]
AB  - INTRODUCTION: Gastro-Intestinal Stromal Tumours (GISTs) are rare with an
      estimated incidence of only 11-15 per million. In pregnancy, GISTs are an
      extremely rare occurrence and are thus complex to manage from an ethical,
      surgical and oncological perspective. PRESENTATION OF CASE: We present the first 
      reported case in the literature of a successful combined lower segment caesarean 
      section (LSCS) and a tumour resection in a 31-year-old pregnant patient
      presenting with a small bowel GIST. DISCUSSION: We compare and contrast our case 
      with other reported cases of GIST resection in pregnancy and discuss the
      challenges faced by both patients and clinicians. CONCLUSION: Our case
      demonstrates that a combined LSCS and GIST resection is feasible. In addition,
      our case highlights the importance of both the multidisciplinary setting and the 
      consideration of patients' wishes in the successful management of this complex
      group of patients.
CI  - Crown Copyright (c) 2012. Published by Elsevier Ltd. All rights reserved.
FAU - Haloob, N
AU  - Haloob N
AD  - Lister Hospital, Corey Mill Lane, Stevenage, Hertfordshire SG1 4AB, United
      Kingdom. Electronic address: nora.haloob@nhs.net.
FAU - Slesser, A A P
AU  - Slesser AA
FAU - Haloob, A R
AU  - Haloob AR
FAU - Khan, F
AU  - Khan F
FAU - Bostanci, G
AU  - Bostanci G
FAU - Abdulla, A
AU  - Abdulla A
LA  - eng
PT  - Journal Article
DEP - 20121031
PL  - Netherlands
TA  - Int J Surg Case Rep
JT  - International journal of surgery case reports
JID - 101529872
PMC - PMC3537954
EDAT- 2012/11/24 06:00
MHDA- 2012/11/24 06:01
CRDT- 2012/11/24 06:00
PHST- 2012/08/31 00:00 [received]
PHST- 2012/10/23 00:00 [accepted]
PHST- 2012/11/24 06:00 [entrez]
PHST- 2012/11/24 06:00 [pubmed]
PHST- 2012/11/24 06:01 [medline]
AID - S2210-2612(12)00200-3 [pii]
AID - 10.1016/j.ijscr.2012.10.017 [doi]
PST - ppublish
SO  - Int J Surg Case Rep. 2013;4(1):121-4. doi: 10.1016/j.ijscr.2012.10.017. Epub 2012
      Oct 31.


PMID- 23174444
OWN - NLM
STAT- MEDLINE
DCOM- 20130517
LR  - 20160519
IS  - 1876-2026 (Electronic)
IS  - 1876-2018 (Linking)
VI  - 5
IP  - 4
DP  - 2012 Dec
TI  - Holistic health and well-being: a psycho-spiritual/religious and theological
      perspective.
PG  - 347-50
LID - 10.1016/j.ajp.2012.09.010 [doi]
LID - S1876-2018(12)00184-0 [pii]
AB  - Neuro-biological studies have established the perennial teaching of all the
      world's religious traditions that human persons are primarily religious/spiritual
      beings. They confirm that religion and spirituality are hardwired into the human 
      brain and into human nature. The transcendental dimension of human nature demands
      that progress in man's ethical formation and inner growth is the most essential
      aspect of holistic health. Their experience of the divine led the Hindu sages to 
      commit themselves to establish peace, happiness and well-being for all the human 
      family and the universe. Judeo-Christian theology advocates that human beings
      created in the image of God have potential for theocentric-transcendence.
      Catholic theologians like St. Augustine propose that God has made humans for
      himself and that their hearts are restless until they rest in him. With the
      revolutionary shift in recent years from attacking faith and religion to the
      exploration of the benefits of spirituality and religion for human flourishing,
      the outstanding themes of Christian theology and other religious traditions
      became topics of research in health sciences. Interdisciplinary interaction will 
      result in attaining a profound understanding of the human person and help him/her
      to achieve lasting fulfilment by adequately paying attention to the
      transcendental, religious and spiritual needs.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Vayalilkarottu, John
AU  - Vayalilkarottu J
AD  - Faculty of Arts and Sciences, School of Psychology, Australian Catholic
      University (ACU), Melbourne, Australia. frjohnvofmconv@gmail.com
LA  - eng
PT  - Journal Article
DEP - 20121031
PL  - Netherlands
TA  - Asian J Psychiatr
JT  - Asian journal of psychiatry
JID - 101517820
SB  - IM
MH  - Christianity
MH  - *Holistic Health
MH  - Humans
MH  - *Mental Health
MH  - Religion
MH  - *Religion and Psychology
MH  - *Spirituality
EDAT- 2012/11/24 06:00
MHDA- 2013/05/18 06:00
CRDT- 2012/11/24 06:00
PHST- 2012/04/13 00:00 [received]
PHST- 2012/09/16 00:00 [accepted]
PHST- 2012/11/24 06:00 [entrez]
PHST- 2012/11/24 06:00 [pubmed]
PHST- 2013/05/18 06:00 [medline]
AID - S1876-2018(12)00184-0 [pii]
AID - 10.1016/j.ajp.2012.09.010 [doi]
PST - ppublish
SO  - Asian J Psychiatr. 2012 Dec;5(4):347-50. doi: 10.1016/j.ajp.2012.09.010. Epub
      2012 Oct 31.


PMID- 23174442
OWN - NLM
STAT- MEDLINE
DCOM- 20130517
LR  - 20160519
IS  - 1876-2026 (Electronic)
IS  - 1876-2018 (Linking)
VI  - 5
IP  - 4
DP  - 2012 Dec
TI  - Sikhism, spirituality and psychiatry.
PG  - 339-43
LID - 10.1016/j.ajp.2012.08.011 [doi]
LID - S1876-2018(12)00174-8 [pii]
AB  - Sikhism has millions of followers in India and among the Indian diaspora. As a
      religion it is relatively young but carries with it unique perspectives which are
      often not well known. The holy book of Sikhism, Guru Granth Sahib, is not only
      the last Guru, but also remained a key text for this religion. Using descriptions
      of the religion and its followers we attempt to understand the context of
      spirituality within this religion and attempt to apply it to clinical settings.
      We explored various texts to understand the notions of spirituality and ethics
      and directions for living one's life. We studied both the Gurumukhi version as
      well as the English translation of the Sikh holy text. In the context of history 
      of the Sikhs, various descriptions related to mental well being were identified. 
      In this paper we describe the history, development and the core values of the
      religion and we also review their role on psychiatric and mental health settings 
      for managing Sikh patients. Guru Granth Sahib offers a very useful insight into
      what is understood by the term equivalent to depression and its phenomenology.
      The notions of dukh (loosely translated as pain, but can also mean sadness or
      suffering) and maya (illusion) and their role in daily living are also discussed.
      In this paper these descriptions are explored further and their importance
      explained.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Kalra, Gurvinder
AU  - Kalra G
AD  - Department of Psychiatry, Lokmanya Tilak Medical College & Sion Hospital, Sion,
      Mumbai 400022, India.
FAU - Bhui, Kamaldeep S
AU  - Bhui KS
FAU - Bhugra, Dinesh
AU  - Bhugra D
LA  - eng
PT  - Journal Article
DEP - 20121009
PL  - Netherlands
TA  - Asian J Psychiatr
JT  - Asian journal of psychiatry
JID - 101517820
SB  - IM
MH  - Culture
MH  - Humans
MH  - Mental Disorders/therapy
MH  - *Psychiatry
MH  - *Religion
MH  - Religion and Psychology
MH  - *Spirituality
EDAT- 2012/11/24 06:00
MHDA- 2013/05/18 06:00
CRDT- 2012/11/24 06:00
PHST- 2012/04/12 00:00 [received]
PHST- 2012/08/10 00:00 [revised]
PHST- 2012/08/13 00:00 [accepted]
PHST- 2012/11/24 06:00 [entrez]
PHST- 2012/11/24 06:00 [pubmed]
PHST- 2013/05/18 06:00 [medline]
AID - S1876-2018(12)00174-8 [pii]
AID - 10.1016/j.ajp.2012.08.011 [doi]
PST - ppublish
SO  - Asian J Psychiatr. 2012 Dec;5(4):339-43. doi: 10.1016/j.ajp.2012.08.011. Epub
      2012 Oct 9.


PMID- 23174079
OWN - NLM
STAT- MEDLINE
DCOM- 20130521
LR  - 20121123
IS  - 1531-6564 (Electronic)
IS  - 0363-5023 (Linking)
VI  - 37
IP  - 12
DP  - 2012 Dec
TI  - Guidelines for ethical and professional use of social media in a hand surgery
      practice.
PG  - 2636-41
LID - 10.1016/j.jhsa.2012.10.002 [doi]
LID - S0363-5023(12)01485-2 [pii]
AB  - In growing numbers, patients are using social media platforms as resources to
      obtain health information and report their experiences in the health care
      setting. More physicians are making use of these platforms as a means to reach
      prospective and existing patients, to share information with each other, and to
      educate the public. In this ever-expanding online dialogue, questions have arisen
      regarding appropriate conduct of the physician during these interactions. The
      purpose of this article is to review the laws that govern online communication as
      they pertain to physician presence in this forum and to discuss appropriate
      ethical and professional behavior in this setting.
CI  - Copyright (c) 2012 American Society for Surgery of the Hand. Published by
      Elsevier Inc. All rights reserved.
FAU - Lifchez, Scott D
AU  - Lifchez SD
AD  - Department of Plastic Surgery, Johns Hopkins Bayview Medical Center, Baltimore,
      MD 21224, USA. Slifche1@jhmi.edu
FAU - McKee, Desirae M
AU  - McKee DM
FAU - Raven, Raymond B 3rd
AU  - Raven RB 3rd
FAU - Shafritz, Adam B
AU  - Shafritz AB
FAU - Tueting, Jonathan L
AU  - Tueting JL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Hand Surg Am
JT  - The Journal of hand surgery
JID - 7609631
SB  - IM
MH  - American Recovery and Reinvestment Act
MH  - Blogging
MH  - Communication
MH  - Confidentiality
MH  - Electronic Mail
MH  - Guidelines as Topic
MH  - Hand/*surgery
MH  - Health Insurance Portability and Accountability Act
MH  - Humans
MH  - Orthopedics/*ethics
MH  - Physician-Patient Relations
MH  - Physicians/standards
MH  - Social Media/*ethics/legislation & jurisprudence/*standards
MH  - Societies, Medical/legislation & jurisprudence
MH  - United States
EDAT- 2012/11/24 06:00
MHDA- 2013/05/23 06:00
CRDT- 2012/11/24 06:00
PHST- 2012/08/18 00:00 [received]
PHST- 2012/10/05 00:00 [accepted]
PHST- 2012/11/24 06:00 [entrez]
PHST- 2012/11/24 06:00 [pubmed]
PHST- 2013/05/23 06:00 [medline]
AID - S0363-5023(12)01485-2 [pii]
AID - 10.1016/j.jhsa.2012.10.002 [doi]
PST - ppublish
SO  - J Hand Surg Am. 2012 Dec;37(12):2636-41. doi: 10.1016/j.jhsa.2012.10.002.


PMID- 23174038
OWN - NLM
STAT- MEDLINE
DCOM- 20130226
LR  - 20121123
IS  - 1049-023X (Print)
IS  - 1049-023X (Linking)
VI  - 27
IP  - 6
DP  - 2012 Dec
TI  - Ethics in EMS and disaster research.
PG  - 495
LID - 10.1017/S1049023X12001495 [doi]
FAU - Stratton, Samuel J
AU  - Stratton SJ
LA  - eng
PT  - Editorial
PL  - United States
TA  - Prehosp Disaster Med
JT  - Prehospital and disaster medicine
JID - 8918173
MH  - Emergency Medical Services/*ethics
MH  - *Ethics, Research
MH  - *Helsinki Declaration
MH  - Humans
EDAT- 2012/11/24 06:00
MHDA- 2013/02/27 06:00
CRDT- 2012/11/24 06:00
PHST- 2012/11/24 06:00 [entrez]
PHST- 2012/11/24 06:00 [pubmed]
PHST- 2013/02/27 06:00 [medline]
AID - S1049023X12001495 [pii]
AID - 10.1017/S1049023X12001495 [doi]
PST - ppublish
SO  - Prehosp Disaster Med. 2012 Dec;27(6):495. doi: 10.1017/S1049023X12001495.


PMID- 23173894
OWN - NLM
STAT- MEDLINE
DCOM- 20130513
LR  - 20181202
IS  - 1525-139X (Electronic)
IS  - 0894-0959 (Linking)
VI  - 25
IP  - 6
DP  - 2012 Nov-Dec
TI  - Age should be considered in the allocation of deceased donor kidneys.
PG  - 682-5
LID - 10.1111/sdi.12034 [doi]
AB  - Organ allocation is a specific example of the allocation of scarce resources in a
      pluralistic society. As such, it is subject to both governmental and public
      scrutiny. It must follow the requirements of the federal legislation and
      regulations regarding "equitable allocation of organs." An ideal allocation
      system should balance the ethical concepts of equity, or fairness, and utility,
      or usefulness. The current kidney allocation system has been in place, with some 
      modifications over time, since the mid-1980s. It suffers from the changing
      demographics in ESRD, notably the aging of these groups, and in the growing
      length of the kidney waiting list. The current algorithm is thus imbalanced and
      requires reexamination. In particular, the system fails to match kidneys with
      long-projected function to recipients with long-projected lifespans, and vice
      versa. To improve the utility of kidney transplantation and lengthen the useful
      lifespan of these organs, a system that better matches kidneys and recipients is 
      necessary, and this will require the use of recipient age in those calculations. 
      The ethical questions and justification of such a system are presented.
CI  - (c) 2012 Wiley Periodicals, Inc.
FAU - Shapiro, Michael E
AU  - Shapiro ME
AD  - Department of Surgery, Hackensack University Medical Center, Hackensack, New
      Jersey 07601, USA. mshapiro@hackensackumc.org
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Semin Dial
JT  - Seminars in dialysis
JID - 8911629
SB  - IM
CON - Semin Dial. 2012 Nov-Dec;25(6):675-81. PMID: 23078079
MH  - Humans
MH  - Kidney Failure, Chronic/*surgery
MH  - *Kidney Transplantation
MH  - Patient Selection/*ethics
MH  - *Tissue and Organ Procurement
EDAT- 2012/11/24 06:00
MHDA- 2013/05/15 06:00
CRDT- 2012/11/24 06:00
PHST- 2012/11/24 06:00 [entrez]
PHST- 2012/11/24 06:00 [pubmed]
PHST- 2013/05/15 06:00 [medline]
AID - 10.1111/sdi.12034 [doi]
PST - ppublish
SO  - Semin Dial. 2012 Nov-Dec;25(6):682-5. doi: 10.1111/sdi.12034.


PMID- 23173509
OWN - NLM
STAT- MEDLINE
DCOM- 20130114
LR  - 20121122
IS  - 0883-5381 (Print)
IS  - 0883-5381 (Linking)
VI  - 27
IP  - 6
DP  - 2012 Nov-Dec
TI  - The ethics of avoiding nonbeneficial healthcare: unnecessary treatment has both
      financial and moral implications.
PG  - 48, 50-1
FAU - Nelson, William A
AU  - Nelson WA
AD  - Dartmouth Institute for Health Policy and Clinical Practice, Geisel School of
      Medicine, USA. william.a.nelson@dartmouth.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Healthc Exec
JT  - Healthcare executive
JID - 8612808
MH  - Hospital Administrators
MH  - Leadership
MH  - Professional Role
MH  - Quality Assurance, Health Care
MH  - United States
MH  - Unnecessary Procedures/*economics/*ethics
EDAT- 2012/11/24 06:00
MHDA- 2013/01/15 06:00
CRDT- 2012/11/24 06:00
PHST- 2012/11/24 06:00 [entrez]
PHST- 2012/11/24 06:00 [pubmed]
PHST- 2013/01/15 06:00 [medline]
PST - ppublish
SO  - Healthc Exec. 2012 Nov-Dec;27(6):48, 50-1.


PMID- 23173265
OWN - NLM
STAT- MEDLINE
DCOM- 20131230
LR  - 20161018
IS  - 1003-5370 (Print)
IS  - 1003-5370 (Linking)
VI  - 32
IP  - 8
DP  - 2012 Aug
TI  - [The difference in acknowledging the AAHRPP between China and America].
PG  - 1117-20
AB  - With the active encouragement of the Chinese government, all domestic clinical
      research institutes pay more attention to the human research protect program
      (HRPP) during the process of clinical trials, and actively follow the regulations
      of medical ethical practice. We could make fully preparation for the
      accreditation by the correlated international organizations only by further
      analyzing the Association for Accreditation of Human Research Protection Program 
      (AAHRPP) from a whole and in each accreditation field at different levels, thus
      having a clear understanding the difference in acknowledging the difference
      between China's hospitals and America's hospitals.
FAU - Zi, Ming-jie
AU  - Zi MJ
AD  - Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing.
FAU - Tang, Xu-dong
AU  - Tang XD
FAU - Gao, Rui
AU  - Gao R
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Zhong Xi Yi Jie He Za Zhi
JT  - Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese
      journal of integrated traditional and Western medicine
JID - 9211576
SB  - IM
MH  - *Accreditation
MH  - China
MH  - Clinical Trials as Topic/*legislation & jurisprudence
MH  - Humans
MH  - *Public Policy
MH  - United States
EDAT- 2012/11/24 06:00
MHDA- 2014/01/01 06:00
CRDT- 2012/11/24 06:00
PHST- 2012/11/24 06:00 [entrez]
PHST- 2012/11/24 06:00 [pubmed]
PHST- 2014/01/01 06:00 [medline]
PST - ppublish
SO  - Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012 Aug;32(8):1117-20.


PMID- 23173007
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1741-0541 (Print)
IS  - 1741-0541 (Linking)
VI  - 9
IP  - 5
DP  - 2012
TI  - Genomic medicine: evolving science, evolving ethics.
PG  - 523-528
AB  - Genomic medicine is rapidly evolving. Next-generation sequencing is changing the 
      diagnostic paradigm by allowing genetic testing to be carried out more quickly,
      less expensively and with much higher resolution; pushing the envelope on
      existing moral norms and legal regulations. Early experience with implementation 
      of next-generation sequencing to diagnose rare genetic conditions in symptomatic 
      children suggests ways that genomic medicine might come to be used and some of
      the ethical issues that arise, impacting test design, patient selection, consent,
      sequencing analysis and communication of results. The ethical issues that arise
      from use of new technologies cannot be satisfactorily analyzed until they are
      understood and they cannot be understood until the technologies are deployed in
      the real world.
FAU - Soden, Sarah E
AU  - Soden SE
AD  - University of Missouri, Children's Mercy Hospital, Kansas City, MO, USA.
FAU - Farrow, Emily G
AU  - Farrow EG
FAU - Saunders, Carol J
AU  - Saunders CJ
FAU - Lantos, John D
AU  - Lantos JD
LA  - eng
GR  - R21 HG006613/HG/NHGRI NIH HHS/United States
GR  - UL1 TR000001/TR/NCATS NIH HHS/United States
PT  - Journal Article
PL  - England
TA  - Per Med
JT  - Personalized medicine
JID - 101238549
PMC - PMC3500993
MID - NIHMS406038
EDAT- 2012/11/23 06:00
MHDA- 2012/11/23 06:01
CRDT- 2012/11/23 06:00
PHST- 2012/11/23 06:00 [entrez]
PHST- 2012/11/23 06:00 [pubmed]
PHST- 2012/11/23 06:01 [medline]
AID - 10.2217/pme.12.56 [doi]
PST - ppublish
SO  - Per Med. 2012;9(5):523-528. doi: 10.2217/pme.12.56.


PMID- 23172984
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 0717-5906 (Print)
IS  - 0717-5906 (Linking)
VI  - 18
IP  - 1
DP  - 2012 Jun 1
PG  - 63-68
AB  - This article presents the experience acquired by participating in the
      international ethics of biomedical and psychosocial research training program of 
      the Interdisciplinary Center for Studies on Bioethics of the University of Chile 
      (2003-2004) and some reflections about the integration of knowledge acquired in
      my posterior work at scientific ethical review committees and ethics of research 
      academic programs. Furthermore, in the elaboration of regulations for improving
      scientific and ethical review.
FAU - Moreno-Exebio, Luis
AU  - Moreno-Exebio L
AD  - Centro Nacional de Control de Calidad, Instituto Nacional de Salud, Peru. Fogarty
      NIH Research Grant #D43 TW 06056. Ano de egreso: 2004.
LA  - spa
GR  - R25 TW006056/TW/FIC NIH HHS/United States
PT  - Journal Article
TT  - Eight years of bioethics.
PL  - Chile
TA  - Acta Bioeth
JT  - Acta bioethica
JID - 101259128
PMC - PMC3501253
MID - NIHMS373243
EDAT- 2012/11/23 06:00
MHDA- 2012/11/23 06:01
CRDT- 2012/11/23 06:00
PHST- 2012/11/23 06:00 [entrez]
PHST- 2012/11/23 06:00 [pubmed]
PHST- 2012/11/23 06:01 [medline]
AID - 10.4067/S1726-569X2012000100004 [doi]
PST - ppublish
SO  - Acta Bioeth. 2012 Jun 1;18(1):63-68. doi: 10.4067/S1726-569X2012000100004.


PMID- 23172899
OWN - NLM
STAT- MEDLINE
DCOM- 20130325
LR  - 20181202
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 2
DP  - 2013 Feb
TI  - Medico-legal and ethical aspects of nasal fractures secondary to assault: do we
      owe a duty of care to advise patients to have a facial x-ray?
PG  - 125-6
LID - 10.1136/medethics-2011-100155 [doi]
AB  - Guidelines advise that x-rays do not contribute to the clinical management of
      simple nasal fractures. However, in cases of simple nasal fracture secondary to
      assault, a facial x-ray may provide additional legal evidence should the victim
      wish to press charges, though there is no published guidance. We examine the
      ethical and medico-legal issues surrounding this controversial area.
FAU - Jaberoo, Marie-Claire
AU  - Jaberoo MC
AD  - Department of Otorhinolaryngology, St Bartholomew's Hospital, London, UK.
      mcjaberoo@gmail.com
FAU - Joseph, Jonathan
AU  - Joseph J
FAU - Korgaonkar, Gillian
AU  - Korgaonkar G
FAU - Mylvaganam, Kandappu
AU  - Mylvaganam K
FAU - Adams, Ben
AU  - Adams B
FAU - Keene, Malcolm
AU  - Keene M
LA  - eng
PT  - Journal Article
DEP - 20121121
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Counseling/*ethics
MH  - Criminal Law
MH  - Ethics, Medical
MH  - Humans
MH  - Nasal Bone/*diagnostic imaging/*injuries
MH  - Photography
MH  - Radiography/adverse effects/ethics/statistics & numerical data
MH  - Skull Fractures/*diagnostic imaging
MH  - United Kingdom
MH  - *Violence
EDAT- 2012/11/23 06:00
MHDA- 2013/03/26 06:00
CRDT- 2012/11/23 06:00
PHST- 2012/11/23 06:00 [entrez]
PHST- 2012/11/23 06:00 [pubmed]
PHST- 2013/03/26 06:00 [medline]
AID - medethics-2011-100155 [pii]
AID - 10.1136/medethics-2011-100155 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Feb;39(2):125-6. doi: 10.1136/medethics-2011-100155. Epub 2012
      Nov 21.


PMID- 23172048
OWN - NLM
STAT- MEDLINE
DCOM- 20131216
LR  - 20181202
IS  - 1745-655X (Electronic)
IS  - 0197-5897 (Linking)
VI  - 34
IP  - 1
DP  - 2013 Jan
TI  - Commentary: Corporate philanthropy and conflicts of interest in public health.
PG  - 137-9
LID - 10.1057/jphp.2012.63 [doi]
AB  - This commentary discusses how ethicists view the responsibilities of
      corporations, of their philanthropic spin-offs, and of not-for-profit
      organizations with regard to use of monies from corporate philanthropies for
      public health. Article JPHP.2012.60 available at www.palgrave-journals.com/jphp/,
      relates to this commentary.
FAU - Krimsky, Sheldon
AU  - Krimsky S
AD  - Department of Urban & Environmental Policy & Planning, Tufts University, 97
      Talbot Avenue, Medford, MA 02155, USA. sheldon.krimsky@tufts.edu
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20121122
PL  - England
TA  - J Public Health Policy
JT  - Journal of public health policy
JID - 8006508
SB  - IM
CON - J Public Health Policy. 2013 Jan;34(1):121-36. PMID: 23172050
MH  - *Conflict of Interest
MH  - Extraction and Processing Industry/*ethics
MH  - Fund Raising/*ethics
MH  - Humans
MH  - Malaria/*epidemiology
MH  - Public Health/*ethics
EDAT- 2012/11/23 06:00
MHDA- 2013/12/18 06:00
CRDT- 2012/11/23 06:00
PHST- 2012/11/23 06:00 [entrez]
PHST- 2012/11/23 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
AID - jphp201263 [pii]
AID - 10.1057/jphp.2012.63 [doi]
PST - ppublish
SO  - J Public Health Policy. 2013 Jan;34(1):137-9. doi: 10.1057/jphp.2012.63. Epub
      2012 Nov 22.


PMID- 23171746
OWN - NLM
STAT- MEDLINE
DCOM- 20130524
LR  - 20191210
IS  - 2245-1919 (Electronic)
IS  - 2245-1919 (Linking)
VI  - 59
IP  - 11
DP  - 2012 Nov
TI  - Steady progress seen in endoscopic surgery on major salivary glands.
PG  - A4525
AB  - INTRODUCTION: The objective of this study was to investigate the development in
      sialendoscopy (SE) in East Denmark. Data were compared with previously published 
      data to assess the learning curve. MATERIAL AND METHODS: In this retrospective
      consecutive study, all patients who had SE performed at Hillerod Hospital from
      November 2009 to April 2011 were included. Data were extracted from medical
      records and interviews. Two surgeons performed all SEs. Z-test and Fisher's exact
      test were used for statistical analysis. RESULTS: A total of 118 patients met the
      inclusion criteria. In all, 156 diagnostic and 139 therapeutic SEs were
      performed. The median age was 44 years (3-85 years) and the female-to-male-ratio 
      was 1.81. A total of 96% of patients had pre-operative ultrasound performed (the 
      positive predictive value for detection of stone was 0.82, 95% confidence
      interval 0.70-0.90. Indication for SE was recurrent or chronic swelling, pain,
      identified stone or recurrent infections. The only exclusion criterion was
      neoplasms. The success rate of diagnostic SE was 98%, and the therapeutic SE
      success rate was 67%. Total or partial relief from symptoms was obtained in 77%
      of patients which was a significant improvement (Z-test: p < 0.001). No serious
      persistent complications occurred. CONCLUSION: SE is a safe and effective
      treatment for benign obstructive disease of the major salivary glands. The
      surgeon's results improve significantly over time. Updated equipment and an
      experienced surgeon yielded patient symptom relief in 77% of cases. FUNDING: not 
      relevant. TRIAL REGISTRATION: This study was approved by the Danish Committee on 
      Biomedical Research Ethics and the Danish Data Protection Agency.
FAU - Rasmussen, Eva Rye
AU  - Rasmussen ER
AD  - Ore-, naese-, halskirurgisk Afdeling, Koge Sygehus, Koge, Denmark.
      eva.rye.rasmussen@dadlnet.dk
FAU - Arndal, Helge
AU  - Arndal H
FAU - Rasmussen, Stig Hebbelstrup
AU  - Rasmussen SH
FAU - Wagner, Niels
AU  - Wagner N
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Denmark
TA  - Dan Med J
JT  - Danish medical journal
JID - 101576205
SB  - IM
MH  - Adult
MH  - Aged, 80 and over
MH  - Child, Preschool
MH  - Data Interpretation, Statistical
MH  - Denmark
MH  - Endoscopes, Gastrointestinal/*standards
MH  - *Endoscopy, Digestive System/adverse effects/instrumentation/methods/statistics &
      numerical data
MH  - Female
MH  - Health Care Surveys
MH  - Humans
MH  - Male
MH  - Medical Records/statistics & numerical data
MH  - Outcome and Process Assessment, Health Care
MH  - *Postoperative Complications/classification/epidemiology
MH  - Quality Improvement
MH  - Retrospective Studies
MH  - *Salivary Gland Diseases/diagnosis/surgery
MH  - *Salivary Glands/pathology/surgery
EDAT- 2012/11/23 06:00
MHDA- 2013/05/28 06:00
CRDT- 2012/11/23 06:00
PHST- 2012/11/23 06:00 [entrez]
PHST- 2012/11/23 06:00 [pubmed]
PHST- 2013/05/28 06:00 [medline]
AID - A4525 [pii]
PST - ppublish
SO  - Dan Med J. 2012 Nov;59(11):A4525.


PMID- 23171648
OWN - NLM
STAT- MEDLINE
DCOM- 20130306
LR  - 20211021
IS  - 1741-7015 (Electronic)
IS  - 1741-7015 (Linking)
VI  - 10
DP  - 2012 Nov 21
TI  - Methodological quality of English-language genetic guidelines on hereditary
      breast-cancer screening and management: an evaluation using the AGREE instrument.
PG  - 143
LID - 10.1186/1741-7015-10-143 [doi]
AB  - BACKGROUND: We examined the methodological quality of guidelines on syndromes
      conferring genetic susceptibility to breast cancer. METHODS: PubMed, EMBASE, and 
      Google were searched for guidelines published up to October 2010. All guidelines 
      in English were included. The Appraisal of Guidelines, Research and Evaluation
      (AGREE) instrument was used to assess the quality of the guidelines, and their
      reported evidence base was evaluated. RESULTS: Thirteen guidelines were deemed
      eligible: seven had been developed by independent associations, and the other six
      had national/state endorsements. Four guidelines performed satisfactorily,
      achieving a score of greater than 50% in all six AGREE domains. Mean +/- SD
      standardized scores for the six AGREE domains were: 90 +/- 9% for 'scope and
      purpose', 51 +/- 18% for 'stakeholder involvement', 55 +/- 27% for 'rigour of
      development', 80 +/- 11% for 'clarity and presentation', 37 +/- 32% for
      'applicability', and 47 +/- 38% for 'editorial independence'. Ten of the thirteen
      guidelines were found to be based on research evidence. CONCLUSIONS: Given the
      ethical implications and the high costs of genetic testing for hereditary breast 
      cancer, guidelines on this topic should provide clear and evidence-based
      recommendations. Our analysis shows that there is scope for improving many
      aspects of the methodological quality of current guidelines. The AGREE instrument
      is a useful tool, and could be used profitably by guidelines developers to
      improve the quality of recommendations.
FAU - Simone, Benedetto
AU  - Simone B
AD  - Institute of Hygiene, Universita Cattolica del Sacro Cuore, L,go F, Vito 1, 00168
      Rome, Italy.
FAU - De Feo, Emma
AU  - De Feo E
FAU - Nicolotti, Nicola
AU  - Nicolotti N
FAU - Ricciardi, Walter
AU  - Ricciardi W
FAU - Boccia, Stefania
AU  - Boccia S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121121
PL  - England
TA  - BMC Med
JT  - BMC medicine
JID - 101190723
SB  - IM
MH  - Female
MH  - Genetic Testing/*methods/*standards
MH  - *Guidelines as Topic
MH  - *Health Services Research
MH  - Hereditary Breast and Ovarian Cancer Syndrome/*diagnosis/*therapy
MH  - Humans
MH  - Quality Control
PMC - PMC3520768
EDAT- 2012/11/23 06:00
MHDA- 2013/03/07 06:00
CRDT- 2012/11/23 06:00
PHST- 2012/05/15 00:00 [received]
PHST- 2012/11/21 00:00 [accepted]
PHST- 2012/11/23 06:00 [entrez]
PHST- 2012/11/23 06:00 [pubmed]
PHST- 2013/03/07 06:00 [medline]
AID - 1741-7015-10-143 [pii]
AID - 10.1186/1741-7015-10-143 [doi]
PST - epublish
SO  - BMC Med. 2012 Nov 21;10:143. doi: 10.1186/1741-7015-10-143.


PMID- 23171607
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121123
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 6
DP  - 2012
TI  - An analysis of the content and clinical implications of online advertisements for
      female genital cosmetic surgery.
LID - 10.1136/bmjopen-2012-001908 [doi]
LID - e001908 [pii]
AB  - OBJECTIVES: Women who are contemplating any form of female genital cosmetic
      surgery (FGCS) are likely to seek information from provider websites. The aim of 
      this study is to examine the breadth, depth and quality of clinical information
      communicated to women on 10 popular sites and to discuss the implications of the 
      results. METHODS: The content of online advertisement from 10 private providers
      that offer FGCS procedures was examined according to 16 information categories
      relating to indications for surgery, types of procedure, risks and benefits.
      RESULTS: FGCS procedures were presented on all of the provider websites as an
      effective treatment for genital appearance concerns. No explanation for
      presenting clinical complaints was found. There was scanty reference to
      appearance diversity. Only minimal scientific information on outcomes or risks
      could be identified. There was no mention of potential alternative ways for
      managing appearance concerns or body dissatisfaction. CONCLUSIONS: The quality
      and quantity of clinical information in FGCS provider sites is poor, with
      erroneous information in some instances. Impeccable professionalism and ethical
      integrity is crucial for this controversial practice. Clear and detailed
      guidelines on how to raise the standard of information to women on all aspects of
      FGCS are urgently needed.
FAU - Liao, Lih-Mei
AU  - Liao LM
AD  - UCL Elizabeth Garrett Anderson Institute of Women's Health, University College
      Hospital, London, UK.
FAU - Taghinejadi, Neda
AU  - Taghinejadi N
FAU - Creighton, Sarah M
AU  - Creighton SM
LA  - eng
PT  - Journal Article
DEP - 20121121
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3533050
EDAT- 2012/11/23 06:00
MHDA- 2012/11/23 06:01
CRDT- 2012/11/23 06:00
PHST- 2012/11/23 06:00 [entrez]
PHST- 2012/11/23 06:00 [pubmed]
PHST- 2012/11/23 06:01 [medline]
AID - bmjopen-2012-001908 [pii]
AID - 10.1136/bmjopen-2012-001908 [doi]
PST - epublish
SO  - BMJ Open. 2012 Nov 21;2(6). pii: bmjopen-2012-001908. doi:
      10.1136/bmjopen-2012-001908. Print 2012.


PMID- 23170806
OWN - NLM
STAT- MEDLINE
DCOM- 20141222
LR  - 20181202
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 14
IP  - 1
DP  - 2014 Apr
TI  - On abortion: exploring psychological meaning and attitudes in a sample of Mexican
      gynecologists.
PG  - 29-36
LID - 10.1111/dewb.12005 [doi]
AB  - Elective abortion has become an issue of ethical and political debate in many
      countries including Mexico. As gynecologists are directly involved in the
      practice of abortion, it is important to know the psychological meaning that the 
      term 'elective abortion' has for them. This study explores the psychological
      meaning and attitudes toward elective abortion of one hundred and twenty-three
      Mexican gynecologists. We used the semantic networks technique, which analyzed
      the words the participants associated with the term 'elective abortion'. The
      defining words most frequently used by participants implied a negative sanction. 
      There were important differences by gender and religiosity: male gynecologists,
      as well as those with strong religious beliefs (mainly Catholics), revealed a
      more negative psychological meaning and more negative attitudes than females or
      physicians with weak religious beliefs. A contribution of the present study is
      that it highlights the importance of psychology to enhancing understanding of the
      issue of elective abortion.
CI  - (c) 2012 John Wiley & Sons Ltd.
FAU - Marvan, Ma Luisa
AU  - Marvan ML
AD  - Instituto de Investigaciones Psicologicas, Universidad Veracruzana, Av. Dr. Luis 
      Castelazo Ayala s/n Col. Industrial Animas Xalapa, Ver, 91190, Mexico.
      mlmarvan@gmail.com.
FAU - Alvarez del Rio, Asuncion
AU  - Alvarez del Rio A
FAU - Campos, Zaira
AU  - Campos Z
LA  - eng
PT  - Journal Article
DEP - 20121122
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
SB  - IM
MH  - Abortion, Induced/*psychology
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - *Catholicism/psychology
MH  - Christianity/psychology
MH  - Female
MH  - *Gynecology
MH  - Humans
MH  - Male
MH  - Mexico
MH  - Middle Aged
MH  - *Physicians/psychology/statistics & numerical data
MH  - Pregnancy
MH  - Sex Distribution
MH  - Sex Factors
MH  - Surveys and Questionnaires
MH  - Workforce
OTO - NOTNLM
OT  - Mexico
OT  - bioethics
OT  - developing world
OT  - empirical
OT  - health
EDAT- 2012/11/23 06:00
MHDA- 2014/12/23 06:00
CRDT- 2012/11/23 06:00
PHST- 2012/11/23 06:00 [entrez]
PHST- 2012/11/23 06:00 [pubmed]
PHST- 2014/12/23 06:00 [medline]
AID - 10.1111/dewb.12005 [doi]
PST - ppublish
SO  - Dev World Bioeth. 2014 Apr;14(1):29-36. doi: 10.1111/dewb.12005. Epub 2012 Nov
      22.


PMID- 23170779
OWN - NLM
STAT- MEDLINE
DCOM- 20141222
LR  - 20191210
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 14
IP  - 1
DP  - 2014 Apr
TI  - Ethical considerations in clinical trials: a critique of the ICH-GCP guideline.
PG  - 20-8
LID - 10.1111/dewb.12004 [doi]
AB  - This article examines issues relating to ethics decision-making in clinical
      trials. The overriding concern is to ensure that the well being and the interests
      of human subjects are adequately safeguarded. In this respect, this article will 
      embark on a critical analysis of the ICH-GCP Guideline. The purpose of such an
      undertaking is to highlight areas of concern and the shortcomings of the existing
      ICH-GCP Guideline. Particular emphasis is made on how ethics committees perform
      their duties and responsibilities in line with the principles outlined in the
      ICH-GCP Guideline. This article will draw attention to the need for a new
      approach to addressing the weaknesses of the ICH-GCP Guideline in its present
      form.
CI  - (c) 2012 John Wiley & Sons Ltd.
FAU - Kaur, Sharon
AU  - Kaur S
AD  - Faculty of Law, University of Malaya, 50603, Kuala Lumpur, Malaysia.
      kaursh@um.edu.my.
FAU - Choy, Choong Yeow
AU  - Choy CY
LA  - eng
PT  - Journal Article
DEP - 20121122
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
SB  - IM
MH  - Clinical Trials as Topic/*ethics
MH  - *Ethics Committees, Research
MH  - Ethics, Research
MH  - Europe
MH  - Guidelines as Topic/*standards
MH  - Humans
MH  - International Cooperation
MH  - Japan
MH  - Outcome and Process Assessment, Health Care/methods
MH  - United States
OTO - NOTNLM
OT  - clinical trials
OT  - developing world
OT  - guidelines
OT  - patient protection
OT  - research ethics
EDAT- 2012/11/23 06:00
MHDA- 2014/12/23 06:00
CRDT- 2012/11/23 06:00
PHST- 2012/11/23 06:00 [entrez]
PHST- 2012/11/23 06:00 [pubmed]
PHST- 2014/12/23 06:00 [medline]
AID - 10.1111/dewb.12004 [doi]
PST - ppublish
SO  - Dev World Bioeth. 2014 Apr;14(1):20-8. doi: 10.1111/dewb.12004. Epub 2012 Nov 22.


PMID- 23170751
OWN - NLM
STAT- Publisher
LR  - 20191120
IS  - 1555-0273 (Electronic)
IS  - 1555-0265 (Linking)
DP  - 2012 Nov 19
TI  - Anti-Inflammatory Effect of Exercise, Via Reduced Leptin Levels, in Obese Women
      with Down Syndrome.
AB  - Recent studies have reported that obese young people with Down syndrome suffer
      from low-grade systemic inflammation. Whereas this condition may be improved in
      the general population by regular exercise, the problem has received no attention
      in the case of people with intellectual disability. Therefore, our aim was to
      assess the influence of aerobic training on plasma adipokines in obese women with
      Down syndrome. Twenty obese young women with Down syndrome volunteered for this
      study, eleven of whom were randomly assigned to a 10-week aerobic training
      programme. They attended 3 sessions/week, which consisted of warm-up exercises
      followed by the main activity on a treadmill (30-40 min) at a work intensity of
      55-65% of peak heart rate, and ended with a cooling-down period. The control
      group included 9 women with Down syndrome matched for age, sex and BMI. Fat mass 
      percentage and distribution were measured and plasma adipokine levels (leptin and
      adiponectin) were assessed. In addition, each participant performed a maximal
      graded continuous treadmill exercise test. These parameters were assessed pre-
      and post-intervention. This protocol was approved by an Institutional Ethics
      Committee. Aerobic training produced a significant increase in participants'
      VO2max (20.2+/-5.8vs.23.7+/-6.3ml/kg/min;p<0.001), and plasma leptin levels were 
      significantly reduced in the intervention group
      (54.2+/-6.7vs.45.7+/-6.1ng/ml;p=0.026). Further significant correlations between 
      plasma leptin and indices of obesity were found. In contrast, no significant
      changes were found in adiponectin levels (p>0.05). None of tested parameters
      changed in the control group. In conclusion, a 10-week training programme reduced
      leptin levels in obese young women with Down syndrome.
FAU - Ordonez, Francisco Javier
AU  - Ordonez FJ
AD  - University of Cadiz, School of Sports Medicine, Cadiz, Spain.
FAU - Fornieles-Gonzalez, Gabriel
AU  - Fornieles-Gonzalez G
FAU - Rosety, Miguel Angel
AU  - Rosety MA
FAU - Rosety, Ignacio
AU  - Rosety I
FAU - Diaz, Antonio
AU  - Diaz A
FAU - Rosety-Rodriguez, Manuel
AU  - Rosety-Rodriguez M
LA  - eng
PT  - Journal Article
DEP - 20121119
PL  - United States
TA  - Int J Sports Physiol Perform
JT  - International journal of sports physiology and performance
JID - 101276430
EDAT- 2012/11/22 06:00
MHDA- 2012/11/22 06:00
CRDT- 2012/11/22 06:00
PHST- 2012/11/22 06:00 [entrez]
PHST- 2012/11/22 06:00 [pubmed]
PHST- 2012/11/22 06:00 [medline]
AID - 2012-0097 [pii]
PST - aheadofprint
SO  - Int J Sports Physiol Perform. 2012 Nov 19. pii: 2012-0097.


PMID- 23169797
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20121224
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 266
IP  - 1
DP  - 2013 Jan
TI  - Kidney transplant: functional assessment with diffusion-tensor MR imaging at 3T.
PG  - 218-25
LID - 10.1148/radiol.12112522 [doi]
AB  - PURPOSE: To evaluate the feasibility of diffusion-tensor (DT) imaging at 3 T for 
      functional assessment of transplanted kidneys. MATERIALS AND METHODS: This study 
      was approved by the local ethics committee; written informed consent was
      obtained. Between August 2009 and October 2010, 40 renal transplant recipients
      were prospectively included in this study and examined with a clinical 3-T
      magnetic resonance (MR) imager. An echo-planar DT imaging sequence was performed 
      in coronal orientation by using five b values (0, 200, 400, 600, 800 sec/mm(2))
      and 20 diffusion directions. The fractional anisotropy (FA) and apparent
      diffusion coefficient (ADC) were determined for the cortex and medulla of the
      transplanted kidney. Relationships between FA, ADC, and allograft function,
      determined by the estimated glomerular filtration rate (eGFR), were assessed by
      using Pearson correlation coefficient. ADC and FA were compared between patients 
      with good or moderate allograft function (group A; eGFR > 30 mL/min/1.73 m(2))
      and patients with impaired function (group B; eGFR </= 30 mL/min/1.73 m(2)) by
      using a student t test. P < .05 indicated a statistically significant difference.
      RESULTS: Mean FA of the renal medulla and cortex was significantly higher in
      group A (0.39 +/- 0.06 and 0.17 +/- 0.4) compared with group B (0.27 +/- 0.05 and
      0.14 +/- 0.03) (P < .001 and P = .009, respectively). Mean ADCs of renal cortex
      and medulla were significantly higher in group A than in group B (P = .007 and P 
      = .01, respectively). In group B, mean medullary FA was significantly lower in
      patients whose renal function did not recover (0.22 +/- 0.02) compared with those
      with stable allograft function at 6 months (0.29 +/- 0.05, P < .001). There was
      significant correlation between eGFR and medullary FA (r = 0.65, P < .001),
      cortical ADC (r = 0.43, P = .003), and medullary ADC (r = 0.35, P = .01).
      CONCLUSION: DT imaging is a promising noninvasive technique for functional
      assessment of renal allografts. FA values in the renal medulla exhibit a good
      correlation with renal function.
CI  - RSNA, 2012
FAU - Lanzman, Rotem S
AU  - Lanzman RS
AD  - Department of Diagnostic and Interventional Radiology, University Dusseldorf,
      Medical Faculty, Moorenstr. 5, 40225 Dusseldorf, Germany. rotemshlomo@yahoo.de
FAU - Ljimani, Alexandra
AU  - Ljimani A
FAU - Pentang, Gael
AU  - Pentang G
FAU - Zgoura, Panagiota
AU  - Zgoura P
FAU - Zenginli, Hakan
AU  - Zenginli H
FAU - Kropil, Patric
AU  - Kropil P
FAU - Heusch, Philipp
AU  - Heusch P
FAU - Schek, Julia
AU  - Schek J
FAU - Miese, Falk R
AU  - Miese FR
FAU - Blondin, Dirk
AU  - Blondin D
FAU - Antoch, Gerald
AU  - Antoch G
FAU - Wittsack, Hans-Jorg
AU  - Wittsack HJ
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
DEP - 20121120
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adult
MH  - Diffusion Magnetic Resonance Imaging/*methods
MH  - Feasibility Studies
MH  - Female
MH  - Graft Rejection/*etiology/*pathology
MH  - Humans
MH  - Kidney Diseases/*etiology/*pathology
MH  - Kidney Function Tests/methods
MH  - Kidney Transplantation/*adverse effects/*pathology
MH  - Middle Aged
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Treatment Outcome
EDAT- 2012/11/22 06:00
MHDA- 2013/02/13 06:00
CRDT- 2012/11/22 06:00
PHST- 2012/11/22 06:00 [entrez]
PHST- 2012/11/22 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
AID - radiol.12112522 [pii]
AID - 10.1148/radiol.12112522 [doi]
PST - ppublish
SO  - Radiology. 2013 Jan;266(1):218-25. doi: 10.1148/radiol.12112522. Epub 2012 Nov
      20.


PMID- 23169794
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20220129
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 266
IP  - 1
DP  - 2013 Jan
TI  - Evaluation of clinically translatable MR imaging biomarkers of therapeutic
      response in the TH-MYCN transgenic mouse model of neuroblastoma.
PG  - 130-40
LID - 10.1148/radiol.12120128 [doi]
AB  - PURPOSE: To evaluate noninvasive and clinically translatable magnetic resonance
      (MR) imaging biomarkers of therapeutic response in the TH-MYCN transgenic mouse
      model of aggressive, MYCN-amplified neuroblastoma. MATERIALS AND METHODS: All
      experiments were performed in accordance with the local ethical review panel and 
      the UK Home Office Animals Scientific Procedures Act 1986 and with the UK
      National Cancer Research Institute guidelines for the welfare of animals in
      cancer research. Multiparametric MR imaging was performed of abdominal tumors
      found in the TH-MYCN model. T2-weighted MR imaging, quantitation of native
      relaxation times T1 and T2, the relaxation rate R2*, and dynamic
      contrast-enhanced MR imaging were used to monitor tumor response to
      cyclophosphamide (25 mg/kg), the vascular disrupting agent ZD6126 (200 mg/kg), or
      the antiangiogenic agent cediranib (6 mg/kg, daily). Any significant changes in
      the measured parameters, and in the magnitude of the changes after treatment
      between treated and control cohorts, were identified by using Student two-tailed 
      paired and unpaired t test, respectively, with a 5% level of significance.
      RESULTS: Treatment with cyclophosphamide or cediranib induced a 54% or 20%
      reduction in tumor volume at 48 hours, respectively (P < .005 and P < .005,
      respectively; P < .005 and P < .005 versus control, respectively). Treatment with
      ZD6126 induced a 45% reduction in mean tumor volume 24 hours after treatment (P <
      .005; P < .005 versus control). The antitumor activity of cyclophosphamide,
      cediranib, and ZD6126 was consistently associated with a decrease in tumor T1 (P 
      < .005, P < .005, and P < .005, respectively; P < .005, P < .005, and P < .005
      versus control, respectively) and with a correlation between therapy-induced
      changes in native T1 and changes in tumor volume (r = 0.56; P < .005). Tumor
      response to cediranib was also associated with a decrease in the dynamic
      contrast-enhanced MR imaging-derived volume transfer constant (P = .07; P < .05
      versus control) and enhancing fraction (P < .05; P < .01 versus control), and an 
      increase in R2* (P < .005; P < .05 versus control). CONCLUSION: The T1 relaxation
      time is a robust noninvasive imaging biomarker of response to therapy in tumors
      in TH-MYCN mice, which emulate high-risk neuroblastoma in children. T1
      measurements can be readily implemented on clinical MR systems and should be
      investigated in translational clinical trials of new targeted therapies for
      pediatric neuroblastoma. SUPPLEMENTAL MATERIAL:
      http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.12120128/-/DC1.
CI  - RSNA, 2012
FAU - Jamin, Yann
AU  - Jamin Y
AD  - Division of Radiotherapy and Imaging, The Institute of Cancer Research and Royal 
      Marsden NHS Foundation Trust, 15 Cotswold Road, Sutton, Surrey SM2 5NG, England. 
      Yann.Jamin@icr.ac.uk
FAU - Tucker, Elizabeth R
AU  - Tucker ER
FAU - Poon, Evon
AU  - Poon E
FAU - Popov, Sergey
AU  - Popov S
FAU - Vaughan, Lynsey
AU  - Vaughan L
FAU - Boult, Jessica K R
AU  - Boult JK
FAU - Webber, Hannah
AU  - Webber H
FAU - Hallsworth, Albert
AU  - Hallsworth A
FAU - Baker, Lauren C J
AU  - Baker LC
FAU - Jones, Chris
AU  - Jones C
FAU - Koh, Dow-Mu
AU  - Koh DM
FAU - Pearson, Andrew D J
AU  - Pearson AD
FAU - Chesler, Louis
AU  - Chesler L
FAU - Robinson, Simon P
AU  - Robinson SP
LA  - eng
GR  - G0700017/MRC_/Medical Research Council/United Kingdom
GR  - 091763/Wellcome Trust/United Kingdom
GR  - 091763Z/10/Z/WT_/Wellcome Trust/United Kingdom
GR  - G1000121/94513/MRC_/Medical Research Council/United Kingdom
GR  - 541/MSS_/Multiple Sclerosis Society/United Kingdom
GR  - C16412/A6269/CRUK_/Cancer Research UK/United Kingdom
GR  - A11924/CRUK_/Cancer Research UK/United Kingdom
GR  - G1000121/1/NC3RS_/National Centre for the Replacement, Refinement and Reduction
      of Animals in Research/United Kingdom
GR  - C36952/A11924/CRUK_/Cancer Research UK/United Kingdom
GR  - C1060/A10334/CRUK_/Cancer Research UK/United Kingdom
GR  - A6269/CRUK_/Cancer Research UK/United Kingdom
GR  - 541/DH_/Department of Health/United Kingdom
GR  - G1100386/MRC_/Medical Research Council/United Kingdom
GR  - A10334/CRUK_/Cancer Research UK/United Kingdom
GR  - G0701533/MRC_/Medical Research Council/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121120
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Biomarkers)
RN  - 0 (MYCN protein, mouse)
RN  - 0 (N-Myc Proto-Oncogene Protein)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/*therapeutic use
MH  - Biomarkers
MH  - *Disease Models, Animal
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Mice
MH  - Mice, Transgenic
MH  - N-Myc Proto-Oncogene Protein
MH  - Neuroblastoma/*drug therapy/*pathology
MH  - Prognosis
MH  - Proto-Oncogene Proteins/genetics
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Treatment Outcome
PMC - PMC4298658
MID - EMS61826
OID - NLM: EMS61826
EDAT- 2012/11/22 06:00
MHDA- 2013/02/13 06:00
CRDT- 2012/11/22 06:00
PHST- 2012/11/22 06:00 [entrez]
PHST- 2012/11/22 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
AID - radiol.12120128 [pii]
AID - 10.1148/radiol.12120128 [doi]
PST - ppublish
SO  - Radiology. 2013 Jan;266(1):130-40. doi: 10.1148/radiol.12120128. Epub 2012 Nov
      20.


PMID- 23169494
OWN - NLM
STAT- MEDLINE
DCOM- 20131021
LR  - 20211021
IS  - 1476-5438 (Electronic)
IS  - 1018-4813 (Linking)
VI  - 21
IP  - 6
DP  - 2013 Jun
TI  - A tiered-layered-staged model for informed consent in personal genome testing.
PG  - 596-601
LID - 10.1038/ejhg.2012.237 [doi]
AB  - In recent years, developments in genomics technologies have led to the rise of
      commercial personal genome testing (PGT): broad genome-wide testing for multiple 
      diseases simultaneously. While some commercial providers require physicians to
      order a personal genome test, others can be accessed directly. All providers
      advertise directly to consumers and offer genetic risk information about dozens
      of diseases in one single purchase. The quantity and the complexity of risk
      information pose challenges to adequate pre-test and post-test information
      provision and informed consent. There are currently no guidelines for what should
      constitute informed consent in PGT or how adequate informed consent can be
      achieved. In this paper, we propose a tiered-layered-staged model for informed
      consent. First, the proposed model is tiered as it offers choices between
      categories of diseases that are associated with distinct ethical, personal or
      societal issues. Second, the model distinguishes layers of information with a
      first layer offering minimal, indispensable information that is material to all
      consumers, and additional layers offering more detailed information made
      available upon request. Finally, the model stages informed consent as a process
      by feeding information to consumers in each subsequent stage of the process of
      undergoing a test, and by accommodating renewed consent for test result updates, 
      resulting from the ongoing development of the science underlying PGT. A
      tiered-layered-staged model for informed consent with a focus on the consumer
      perspective can help overcome the ethical problems of information provision and
      informed consent in direct-to-consumer PGT.
FAU - Bunnik, Eline M
AU  - Bunnik EM
AD  - Department of Medical Ethics and Philosophy of Medicine, Erasmus University
      Medical Center, Rotterdam, The Netherlands. e.bunnik@erasmusmc.nl
FAU - Janssens, A Cecile J W
AU  - Janssens AC
FAU - Schermer, Maartje H N
AU  - Schermer MH
LA  - eng
PT  - Journal Article
DEP - 20121121
PL  - England
TA  - Eur J Hum Genet
JT  - European journal of human genetics : EJHG
JID - 9302235
SB  - IM
MH  - Genetic Testing/*ethics
MH  - Genome, Human/*genetics
MH  - Humans
MH  - Informed Consent/*ethics
MH  - *Models, Theoretical
MH  - Precision Medicine/*ethics
PMC - PMC3658183
EDAT- 2012/11/22 06:00
MHDA- 2013/10/22 06:00
CRDT- 2012/11/22 06:00
PHST- 2012/11/22 06:00 [entrez]
PHST- 2012/11/22 06:00 [pubmed]
PHST- 2013/10/22 06:00 [medline]
AID - ejhg2012237 [pii]
AID - 10.1038/ejhg.2012.237 [doi]
PST - ppublish
SO  - Eur J Hum Genet. 2013 Jun;21(6):596-601. doi: 10.1038/ejhg.2012.237. Epub 2012
      Nov 21.


PMID- 23169492
OWN - NLM
STAT- MEDLINE
DCOM- 20131104
LR  - 20211021
IS  - 1476-5438 (Electronic)
IS  - 1018-4813 (Linking)
VI  - 21
IP  - 7
DP  - 2013 Jul
TI  - The perspective from EASAC and FEAM on direct-to-consumer genetic testing for
      health-related purposes.
PG  - 703-7
LID - 10.1038/ejhg.2012.238 [doi]
AB  - Direct-to-consumer (DTC) genetic testing services raise scientific, regulatory
      and ethical questions. A report was prepared by consultation with an expert
      Working Group and published by the academies of science (European Academies of
      Science Advisory Council, EASAC) and medicine (Federation of European Academies
      of Medicine, FEAM). This report reviews current scientific evidence, ascertains
      the principles that should underpin the options for action by policy-makers, and 
      discusses the potential for devising proportionate and flexible regulation that
      enables future innovation, taking account of the work of other expert groups,
      most notably the European Society of Human Genetics. EASAC-FEAM concluded that
      DTC genetic testing has little clinical value at present, and expresses especial 
      caution in several specific respects, for example relating to testing for high
      penetrance, serious disorders, prenatal screening, nutrigenomic and
      pharmacogenetic testing. It was emphasised that regulation must be on the basis
      that claims about the link between genetic marker and disease are scientifically 
      valid. Other key issues to address include quality assurance (that includes the
      professional interpretation of results), transparent supply of accurate
      information, consideration of the implications for established health services,
      and clarification of consent procedures for any use of data for research
      purposes. There are important implications: for the European Commission, in
      revising the Directive on In Vitro Diagnostic Medical Devices; for professional
      bodies, in supporting training and guideline development; for the broader
      research community, in generating the evidence base; and for the public health
      community, in improving the routine translation of research advances into
      clinical practice.
FAU - Fears, Robin
AU  - Fears R
AD  - EASAC, German National Academy of Sciences Leopoldina, Saale, Germany.
FAU - ter Meulen, Volker
AU  - ter Meulen V
CN  - EASAC-FEAM Working Group
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121121
PL  - England
TA  - Eur J Hum Genet
JT  - European journal of human genetics : EJHG
JID - 9302235
SB  - IM
MH  - Europe
MH  - Female
MH  - Genetic Diseases, Inborn/diagnosis/*genetics/pathology
MH  - *Genetic Testing
MH  - Humans
MH  - Pregnancy
MH  - Prenatal Diagnosis
MH  - *Public Health
MH  - Quality Control
PMC - PMC3722941
IR  - Boccia S
FIR - Boccia, Stefania
IR  - Cornel M
FIR - Cornel, Martina
IR  - Delpech M
FIR - Delpech, Marc
IR  - De Paepe A
FIR - De Paepe, Anne
IR  - Estivill X
FIR - Estivill, Xavier
IR  - Hansson M
FIR - Hansson, Mats
IR  - Karalis K
FIR - Karalis, Katia
IR  - Metspalu A
FIR - Metspalu, Andres
IR  - Propping P
FIR - Propping, Peter
IR  - Sequeiros J
FIR - Sequeiros, Jorge
IR  - Zimmern R
FIR - Zimmern, Ron
IR  - ter Meulen V
FIR - ter Meulen, Volker
IR  - Fears R
FIR - Fears, Robin
IR  - Nothen M
FIR - Nothen, Markus
EDAT- 2012/11/22 06:00
MHDA- 2013/11/05 06:00
CRDT- 2012/11/22 06:00
PHST- 2012/11/22 06:00 [entrez]
PHST- 2012/11/22 06:00 [pubmed]
PHST- 2013/11/05 06:00 [medline]
AID - ejhg2012238 [pii]
AID - 10.1038/ejhg.2012.238 [doi]
PST - ppublish
SO  - Eur J Hum Genet. 2013 Jul;21(7):703-7. doi: 10.1038/ejhg.2012.238. Epub 2012 Nov 
      21.


PMID- 23169186
OWN - NLM
STAT- MEDLINE
DCOM- 20131204
LR  - 20121121
IS  - 1539-073X (Electronic)
IS  - 1520-9229 (Linking)
VI  - 14
IP  - 4
DP  - 2012 Oct-Dec
TI  - Ethical palliative family nursing care: a new concept of caring for patients and 
      families.
PG  - 122-3
LID - 10.1097/NHL.0b013e31827a9258 [doi]
FAU - Maroon, Amanda M
AU  - Maroon AM
AD  - The Jewish Hospital, Cincinnati, Ohio 45236, USA. amandamaroon67@gmail.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - JONAS Healthc Law Ethics Regul
JT  - JONA'S healthcare law, ethics and regulation
JID - 100888423
MH  - Family Nursing/*ethics
MH  - Humans
MH  - *Models, Nursing
MH  - Palliative Care/*ethics
MH  - *Professional-Family Relations
EDAT- 2012/11/22 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/11/22 06:00
PHST- 2012/11/22 06:00 [entrez]
PHST- 2012/11/22 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1097/NHL.0b013e31827a9258 [doi]
AID - 00128488-201210000-00005 [pii]
PST - ppublish
SO  - JONAS Healthc Law Ethics Regul. 2012 Oct-Dec;14(4):122-3. doi:
      10.1097/NHL.0b013e31827a9258.


PMID- 23168353
OWN - NLM
STAT- MEDLINE
DCOM- 20131211
LR  - 20121205
IS  - 1872-9177 (Electronic)
IS  - 1769-7255 (Linking)
VI  - 8
IP  - 7
DP  - 2012 Dec
TI  - [Renal transplantation: ethical issues].
PG  - 547-56
LID - 10.1016/j.nephro.2012.10.001 [doi]
LID - S1769-7255(12)00539-1 [pii]
AB  - One of the most significant advances in medicine during the last 50 years is the 
      development of organ transplantation. In the context of chronic kidney diseases, 
      renal transplantation offers patients a better clinical outcome than other
      treatment options. However, the benefits of organ transplantation have not been
      maximized due to an inadequate supply of organs for transplantation. Despite the 
      establishment of elaborate legal rules for organs procurement, both on deceased
      and living donors in numerous countries, ethical concerns remain. Most of them
      are consequences of the strategies implemented or proposed to address the
      so-called organ shortage. The involvement of society in these complex problems is
      crucial as numerous questions emerge: could actual state of organ procurement
      change? Is it possible and/or realistic to increase the number of organs, with
      respects to living donors or deceased persons? Is the shortage an indicator to
      limit the use of kidney transplantation? How do we maintain efficiency and
      justice, in this context.
CI  - Copyright (c) 2012. Published by Elsevier SAS.
FAU - Mamzer-Bruneel, Marie-France
AU  - Mamzer-Bruneel MF
AD  - Service de transplantation renale, hopital Necker, Assistance publique-Hopitaux
      de Paris, 149, rue de Sevres, 75015 Paris, France.
      marie-france.mamzer@nck.aphp.fr
FAU - Laforet, Emmanuelle Grand
AU  - Laforet EG
FAU - Kreis, Henri
AU  - Kreis H
FAU - Thervet, Eric
AU  - Thervet E
FAU - Martinez, Frank
AU  - Martinez F
FAU - Snanoudj, Renaud
AU  - Snanoudj R
FAU - Herve, Christian
AU  - Herve C
FAU - Legendre, Christophe
AU  - Legendre C
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Aspects ethiques de la transplantation renale (donneurs et receveurs).
DEP - 20121116
PL  - France
TA  - Nephrol Ther
JT  - Nephrologie & therapeutique
JID - 101248950
SB  - IM
MH  - Death
MH  - Humans
MH  - Kidney Transplantation/*ethics
MH  - Presumed Consent/ethics
MH  - Tissue Donors/*ethics/*supply & distribution
MH  - Tissue and Organ Procurement/*ethics
MH  - Waiting Lists
EDAT- 2012/11/22 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/11/22 06:00
PHST- 2012/11/22 06:00 [entrez]
PHST- 2012/11/22 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - S1769-7255(12)00539-1 [pii]
AID - 10.1016/j.nephro.2012.10.001 [doi]
PST - ppublish
SO  - Nephrol Ther. 2012 Dec;8(7):547-56. doi: 10.1016/j.nephro.2012.10.001. Epub 2012 
      Nov 16.


PMID- 23168302
OWN - NLM
STAT- MEDLINE
DCOM- 20130225
LR  - 20211203
IS  - 1532-821X (Electronic)
IS  - 0003-9993 (Linking)
VI  - 94
IP  - 1 Suppl
DP  - 2013 Jan
TI  - Ethical perspectives on knowledge translation in rehabilitation.
PG  - S55-60
LID - 10.1016/j.apmr.2012.08.218 [doi]
LID - S0003-9993(12)00926-4 [pii]
AB  - Although the literature on the ethical dimensions of knowledge creation, use, and
      dissemination is voluminous, it has not particularly examined the ethical
      dimensions of knowledge translation in rehabilitation. Yet, whether research is
      done in a wet lab or treatments are provided to patients in therapeutic settings,
      rehabilitation professionals commonly use (as well as create) knowledge and
      disseminate it to peers, patients, and various others. This article will refer to
      knowledge creation, use, and transfer as knowledge translation and examine some
      of its numerous ethical challenges. Three ethical dimensions of knowledge
      translation will particularly attract our attention: (1) the quality of knowledge
      disseminated to rehabilitationists; (2) ethical challenges in being too easily
      persuaded by or unreasonably resistant to putative knowledge; and (3)
      organizational barriers to knowledge translation. We will conclude with some
      recommendations on facilitating the ethical soundness of knowledge translation in
      rehabilitation.
CI  - Copyright (c) 2013 American Congress of Rehabilitation Medicine. Published by
      Elsevier Inc. All rights reserved.
FAU - Banja, John D
AU  - Banja JD
AD  - Atlanta Clinical and Translational Science Institute, Emory University, Atlanta, 
      GA 30322, USA. jbanja@emory.edu
FAU - Eisen, Arri
AU  - Eisen A
LA  - eng
GR  - UL1 TR000454/TR/NCATS NIH HHS/United States
GR  - UL1TR000454/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20121117
PL  - United States
TA  - Arch Phys Med Rehabil
JT  - Archives of physical medicine and rehabilitation
JID - 2985158R
SB  - IM
MH  - Conflict of Interest
MH  - Humans
MH  - Information Dissemination/*ethics
MH  - Physical Therapy Specialty/*organization & administration
MH  - Rehabilitation
MH  - Translational Research, Biomedical/*ethics
PMC - PMC4325989
MID - NIHMS499559
EDAT- 2012/11/22 06:00
MHDA- 2013/02/26 06:00
CRDT- 2012/11/22 06:00
PHST- 2011/12/21 00:00 [received]
PHST- 2012/05/04 00:00 [revised]
PHST- 2012/08/22 00:00 [accepted]
PHST- 2012/11/22 06:00 [entrez]
PHST- 2012/11/22 06:00 [pubmed]
PHST- 2013/02/26 06:00 [medline]
AID - S0003-9993(12)00926-4 [pii]
AID - 10.1016/j.apmr.2012.08.218 [doi]
PST - ppublish
SO  - Arch Phys Med Rehabil. 2013 Jan;94(1 Suppl):S55-60. doi:
      10.1016/j.apmr.2012.08.218. Epub 2012 Nov 17.


PMID- 23168158
OWN - NLM
STAT- MEDLINE
DCOM- 20130509
LR  - 20191210
IS  - 1945-8932 (Electronic)
IS  - 1945-8932 (Linking)
VI  - 26
IP  - 5
DP  - 2012 Sep-Oct
TI  - The validation of an endoscopic sinus surgery skills training model: a pilot
      study.
PG  - 409-13
LID - 10.2500/ajra.2012.26.3798 [doi]
AB  - BACKGROUND: Performing functional endoscopic sinus surgery (FESS) requires a
      trainee surgeon to develop both thorough anatomic understanding and new manual
      dexterity skills. Traditionally, these skills were learned in the operating room 
      setting. In an era of available surgical simulation, this practice introduces
      ethical concerns about exposing patients to unnecessary risks during surgical
      skills development. Additionally, cost-effective rhinologic training has become
      increasingly important. To address these problems, a low-cost,
      intermediate-fidelity FESS training model was developed, and both speed and
      accuracy of task completion were measured to assess both immediate and
      intermediate-term skills retention. METHODS: Preliminary data were collected on
      12 medical students and 10 resident-level (PGY1, -2, and -3) learners. Distinct
      tasks were performed five times on the initial day of testing and repeated after 
      2 weeks. RESULTS: Both groups attained statistically significant improvement in
      time to complete both tasks by the second iteration of each task and retained
      this effect after 2 weeks. Similarly, statistically significant improvement was
      seen for accuracy relative to the initial attempt by the fifth iteration for
      residents. This effect was also seen by the third through fifth iterations and
      after 2 weeks for students. Additionally, when the 2-week follow-up testing was
      compared with the fifth attempt, the only skills that deteriorated significantly 
      were the resident group with the complex task times and the students with
      measures of accuracy. However, in both cases a highly significant improvement
      from initial attempts was maintained (p = 0.02 and p = 0.005, respectively).
      Residents were significantly faster than medical students at both simple and
      complex tasks for attempts 1 through 4, but this difference was not significant
      for attempt 5 and after 2 weeks. Residents had significantly fewer errors for all
      but the 2-week data point. CONCLUSION: The data from this pilot study support
      improved FESS skills for both medical students and residents using this low-cost,
      intermediate-fidelity model.
FAU - Burge, Scott D
AU  - Burge SD
AD  - Department of Otorhinolaryngology, Oklahoma University College of Medicine,
      Oklahoma City, Oklahoma 73104, USA.
FAU - Bunegin, Leon
AU  - Bunegin L
FAU - Weitzel, Erik K
AU  - Weitzel EK
FAU - McMains, K Christopher
AU  - McMains KC
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Validation Study
PL  - United States
TA  - Am J Rhinol Allergy
JT  - American journal of rhinology & allergy
JID - 101490775
SB  - IM
CIN - Am J Rhinol Allergy. 2013 May-Jun;27(3):251. PMID: 23710963
CIN - Am J Rhinol Allergy. 2013 May-Jun;27(3):251-2. PMID: 23710964
MH  - Cadaver
MH  - Clinical Competence/statistics & numerical data
MH  - Education, Medical, Graduate/*methods
MH  - Humans
MH  - Internship and Residency/*methods
MH  - *Models, Educational
MH  - Natural Orifice Endoscopic Surgery/*education
MH  - Otolaryngology/*education
MH  - Paranasal Sinuses/*surgery
MH  - Pilot Projects
EDAT- 2012/11/22 06:00
MHDA- 2013/05/10 06:00
CRDT- 2012/11/22 06:00
PHST- 2012/11/22 06:00 [entrez]
PHST- 2012/11/22 06:00 [pubmed]
PHST- 2013/05/10 06:00 [medline]
AID - 10.2500/ajra.2012.26.3798 [doi]
PST - ppublish
SO  - Am J Rhinol Allergy. 2012 Sep-Oct;26(5):409-13. doi: 10.2500/ajra.2012.26.3798.


PMID- 23167874
OWN - NLM
STAT- MEDLINE
DCOM- 20130423
LR  - 20121121
IS  - 1743-498X (Electronic)
IS  - 1743-4971 (Linking)
VI  - 9
IP  - 6
DP  - 2012 Dec
TI  - Ethics, publication and The Clinical Teacher.
PG  - 353-5
LID - 10.1111/tct.12009 [doi]
FAU - Thistlethwaite, Jill
AU  - Thistlethwaite J
FAU - Trumble, Steve
AU  - Trumble S
LA  - eng
PT  - Editorial
PL  - England
TA  - Clin Teach
JT  - The clinical teacher
JID - 101227511
SB  - IM
MH  - *Editorial Policies
MH  - *Education, Medical
MH  - Ethics, Research
MH  - Evaluation Studies as Topic
MH  - Periodicals as Topic/*ethics
MH  - Publishing/ethics
MH  - Research Report
EDAT- 2012/11/22 06:00
MHDA- 2013/04/24 06:00
CRDT- 2012/11/22 06:00
PHST- 2012/11/22 06:00 [entrez]
PHST- 2012/11/22 06:00 [pubmed]
PHST- 2013/04/24 06:00 [medline]
AID - 10.1111/tct.12009 [doi]
PST - ppublish
SO  - Clin Teach. 2012 Dec;9(6):353-5. doi: 10.1111/tct.12009.


PMID- 23167212
OWN - NLM
STAT- MEDLINE
DCOM- 20121204
LR  - 20181202
IS  - 0305-5000 (Print)
IS  - 0305-5000 (Linking)
VI  - 39
IP  - 8
DP  - 2012 Oct
TI  - The changing face of dentistry?/Ethical marketing series.
PG  - 589
FAU - Thompson, Owen
AU  - Thompson O
LA  - eng
PT  - Letter
PT  - Comment
PL  - England
TA  - Dent Update
JT  - Dental update
JID - 7805969
CON - Dent Update. 2012 Jul-Aug;39(6):389. PMID: 22928451
MH  - Humans
MH  - *Marketing of Health Services
MH  - Practice Management, Dental/*economics
EDAT- 2012/11/22 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/11/22 06:00
PHST- 2012/11/22 06:00 [entrez]
PHST- 2012/11/22 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.12968/denu.2012.39.8.589a [doi]
PST - ppublish
SO  - Dent Update. 2012 Oct;39(8):589. doi: 10.12968/denu.2012.39.8.589a.


PMID- 23167210
OWN - NLM
STAT- MEDLINE
DCOM- 20121204
LR  - 20181202
IS  - 0305-5000 (Print)
IS  - 0305-5000 (Linking)
VI  - 39
IP  - 8
DP  - 2012 Oct
TI  - The changing face of dentistry?/Ethical marketing series.
PG  - 588-9
FAU - O'Malley, Conor
AU  - O'Malley C
LA  - eng
PT  - Letter
PT  - Comment
PL  - England
TA  - Dent Update
JT  - Dental update
JID - 7805969
CON - Dent Update. 2012 Jun;39(5):313-6, 318-20, 323-4 passim. PMID: 22852509
CON - Dent Update. 2012 Jul-Aug;39(6):389. PMID: 22928451
CON - Dent Update. 2012 Jul-Aug;39(6):390-2, 394-6, 398-400 passim. PMID: 22928452
CON - Dent Update. 2012 Sep;39(7):472-4, 476-8, 481-2 passim. PMID: 23094568
MH  - Dentist-Patient Relations/*ethics
MH  - *Esthetics, Dental
MH  - *Ethics, Dental
MH  - Female
MH  - Humans
MH  - Male
MH  - Marketing of Health Services/*ethics
MH  - Practice Management, Dental/*economics/*ethics
EDAT- 2012/11/22 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/11/22 06:00
PHST- 2012/11/22 06:00 [entrez]
PHST- 2012/11/22 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.12968/denu.2012.39.8.588b [doi]
PST - ppublish
SO  - Dent Update. 2012 Oct;39(8):588-9. doi: 10.12968/denu.2012.39.8.588b.


PMID- 23167209
OWN - NLM
STAT- MEDLINE
DCOM- 20121204
LR  - 20181202
IS  - 0305-5000 (Print)
IS  - 0305-5000 (Linking)
VI  - 39
IP  - 8
DP  - 2012 Oct
TI  - The changing face of dentistry?/Ethical marketing series.
PG  - 588
FAU - Plowman, R L
AU  - Plowman RL
LA  - eng
PT  - Letter
PT  - Comment
PL  - England
TA  - Dent Update
JT  - Dental update
JID - 7805969
CON - Dent Update. 2012 Jul-Aug;39(6):389. PMID: 22928451
MH  - Humans
MH  - *Marketing of Health Services
MH  - Practice Management, Dental/*economics
EDAT- 2012/11/22 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/11/22 06:00
PHST- 2012/11/22 06:00 [entrez]
PHST- 2012/11/22 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.12968/denu.2012.39.8.588a [doi]
PST - ppublish
SO  - Dent Update. 2012 Oct;39(8):588. doi: 10.12968/denu.2012.39.8.588a.


PMID- 23166776
OWN - NLM
STAT- MEDLINE
DCOM- 20130620
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 11
DP  - 2012
TI  - Clinical, ethical and financial implications of incidental imaging findings:
      experience from a phase I trial in healthy elderly volunteers.
PG  - e49814
LID - 10.1371/journal.pone.0049814 [doi]
AB  - BACKGROUND: The detection of incidental findings (IF) in magnetic resonance
      imaging (MRI) studies is common and increases as a function of age. Responsible
      handling of IF is required, with implications for the conduct of research and the
      provision of good clinical care. AIM: To investigate the prevalence and clinical 
      significance of IF in a prospective cohort of healthy elderly volunteers who
      underwent MRI of the torso as a baseline investigation for a phase I trial. We
      assessed the follow-up pathway with consequent cost implications and impact on
      trial outcomes. METHODS: A total of 29 elderly healthy volunteers (mean age 67,
      range 61-77, 59% female) were eligible at screening and underwent MRI for
      assessment of visceral and subcutaneous fat. RESULTS: IF were detected in 19
      subjects (66%). Suspected IF of high and low clinical significance were found in 
      14% and 52% of participants, respectively. Follow up of IF was conducted in 18
      individuals, confirming abnormalities in 13 subjects, 3 of whom were recommended 
      for deferred clinical re-evaluation. The remaining 5 subjects had false positive 
      IF based on second line imaging tests. Costs of follow-up medical care were
      considerable. CONCLUSION: MRI abnormalities are common in elderly individuals, as
      a result of age and non-diagnostic quality of research scans. In the presence of 
      IF in the context of clinical trials, immediate referrals and follow up
      assessments may be required to rule out suspected pathology prior to exposing
      trial participants to investigational medicine products (IMP). Unanticipated
      costs, ethical implication and the possible impact of IF on trial outcomes need
      to be taken into account when designing and conducting trials with an IMP.
FAU - Pinato, David J
AU  - Pinato DJ
AD  - The National Institute for Health Research (NIHR)-Wellcome Trust Imperial College
      Clinical Research Facility, Imperial Centre for Translational and Experimental
      Medicine, Imperial College, Hammersmith Hospital Campus, London, United Kingdom.
FAU - Stavraka, Chara
AU  - Stavraka C
FAU - Tanner, Mark
AU  - Tanner M
FAU - Esson, Audrey
AU  - Esson A
FAU - Jacobson, Eric W
AU  - Jacobson EW
FAU - Wilkins, Martin R
AU  - Wilkins MR
FAU - Libri, Vincenzo
AU  - Libri V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121116
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Aged
MH  - Clinical Trials, Phase I as Topic
MH  - Cost-Benefit Analysis
MH  - Ethics, Clinical
MH  - Female
MH  - Humans
MH  - *Incidental Findings
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Outcome Assessment, Health Care
MH  - Prevalence
PMC - PMC3500322
EDAT- 2012/11/21 06:00
MHDA- 2013/06/21 06:00
CRDT- 2012/11/21 06:00
PHST- 2012/06/09 00:00 [received]
PHST- 2012/10/17 00:00 [accepted]
PHST- 2012/11/21 06:00 [entrez]
PHST- 2012/11/21 06:00 [pubmed]
PHST- 2013/06/21 06:00 [medline]
AID - 10.1371/journal.pone.0049814 [doi]
AID - PONE-D-12-16766 [pii]
PST - ppublish
SO  - PLoS One. 2012;7(11):e49814. doi: 10.1371/journal.pone.0049814. Epub 2012 Nov 16.


PMID- 23166762
OWN - NLM
STAT- MEDLINE
DCOM- 20130620
LR  - 20220316
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 11
DP  - 2012
TI  - MR neurography in ulnar neuropathy as surrogate parameter for the presence of
      disseminated neuropathy.
PG  - e49742
LID - 10.1371/journal.pone.0049742 [doi]
AB  - PURPOSE: Patients with ulnar neuropathy of unclear etiology occasionally present 
      with lesion extension from elbow to upper arm level on MRI. This study
      investigated whether MRI thereby distinguishes multifocal neuropathy from
      focal-compressive neuropathy at the elbow. METHODS: This prospective study was
      approved by the institutional ethics committee and written informed consent was
      obtained from all participants. 122 patients with ulnar mononeuropathy of
      undetermined localization and etiology by clinical and electrophysiological
      examination were assessed by MRI at upper arm and elbow level using T2-weighted
      fat-saturated sequences at 3T. Twenty-one patients were identified with proximal 
      ulnar nerve lesions and evaluated for findings suggestive of disseminated
      neuropathy (i) subclinical lesions in other nerves, (ii) unfavorable outcome
      after previous decompressive elbow surgery, and (iii) subsequent diagnosis of
      inflammatory or other disseminated neuropathy. Two groups served as controls for 
      quantitative analysis of nerve-to-muscle signal intensity ratios: 20 subjects
      with typical focal ulnar neuropathy at the elbow and 20 healthy subjects.
      RESULTS: In the group of 21 patients with proximal ulnar nerve lesion extension, 
      T2-w ulnar nerve signal was significantly (p<0.001) higher at upper arm level
      than in both control groups. A cut-off value of 1.92 for maximum nerve-to-muscle 
      signal intensity ratio was found to be sensitive (86%) and specific (100%) to
      discriminate this group. Ten patients (48%) exhibited additional T2-w lesions in 
      the median and/or radial nerve. Another ten (48%) had previously undergone elbow 
      surgery without satisfying outcome. Clinical follow-up was available in 15 (71%) 
      and revealed definitive diagnoses of multifocal neuropathy of various etiologies 
      in four patients. In another eight, diagnoses could not yet be considered
      definitive but were consistent with multifocal neuropathy. CONCLUSION: Proximal
      ulnar nerve T2 lesions at upper arm level are detected by MRI and indicate the
      presence of a non-focal disseminated neuropathy instead of a focal compressive
      neuropathy.
FAU - Baumer, Philipp
AU  - Baumer P
AD  - Department of Neuroradiology, Heidelberg University Hospital, Heidelberg,
      Germany. philipp.baeumer@med.uni-heidelberg.de
FAU - Weiler, Markus
AU  - Weiler M
FAU - Ruetters, Maurice
AU  - Ruetters M
FAU - Staub, Frank
AU  - Staub F
FAU - Dombert, Thomas
AU  - Dombert T
FAU - Heiland, Sabine
AU  - Heiland S
FAU - Bendszus, Martin
AU  - Bendszus M
FAU - Pham, Mirko
AU  - Pham M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121114
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Blood Vessels/pathology
MH  - Diagnosis, Differential
MH  - Elbow/innervation/surgery
MH  - Fascia/pathology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Ulnar Nerve/pathology/physiopathology
MH  - Ulnar Neuropathies/*diagnosis/etiology
MH  - Young Adult
PMC - PMC3498206
EDAT- 2012/11/21 06:00
MHDA- 2013/06/21 06:00
CRDT- 2012/11/21 06:00
PHST- 2012/09/07 00:00 [received]
PHST- 2012/10/12 00:00 [accepted]
PHST- 2012/11/21 06:00 [entrez]
PHST- 2012/11/21 06:00 [pubmed]
PHST- 2013/06/21 06:00 [medline]
AID - 10.1371/journal.pone.0049742 [doi]
AID - PONE-D-12-27194 [pii]
PST - ppublish
SO  - PLoS One. 2012;7(11):e49742. doi: 10.1371/journal.pone.0049742. Epub 2012 Nov 14.


PMID- 23166146
OWN - NLM
STAT- MEDLINE
DCOM- 20130923
LR  - 20220410
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 20
IP  - 4
DP  - 2013 Jun
TI  - Professional values, self-esteem, and ethical confidence of baccalaureate nursing
      students.
PG  - 479-90
LID - 10.1177/0969733012458608 [doi]
AB  - Professional identity and competent ethical behaviors of nursing students are
      commonly developed through curricular inclusion of professional nursing values
      education. Despite the enactment of this approach, nursing students continue to
      express difficulty in managing ethical conflicts encountered in their practice.
      This descriptive correlational study explores the relationships between
      professional nursing values, self-esteem, and ethical decision making among
      senior baccalaureate nursing students. A convenience sample of 47 senior nursing 
      students from the United States were surveyed for their level of internalized
      professional nursing values (Revised Professional Nursing Values Scale), level of
      self-esteem (Rosenberg's Self-Esteem Scale), and perceived level of confidence in
      ethical decision making. A significant positive relationship (p < 0.05) was found
      between nursing students' professional nursing values and levels of self-esteem. 
      The results of this study can be useful to nursing educators whose efforts are
      focused on promoting professional identity development and competent ethical
      behaviors of future nurses.
FAU - Iacobucci, Trisha A
AU  - Iacobucci TA
AD  - The Breen School of Nursing, Ursuline College, 2550 Lander Road, Pepper Pike, OH 
      44124, USA. tiacobucci@ursuline.edu
FAU - Daly, Barbara J
AU  - Daly BJ
FAU - Lindell, Debbie
AU  - Lindell D
FAU - Griffin, Mary Quinn
AU  - Griffin MQ
LA  - eng
PT  - Journal Article
DEP - 20121119
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Clinical Competence
MH  - Conflict, Psychological
MH  - Education, Nursing, Baccalaureate/*ethics/*standards
MH  - Ethics, Nursing
MH  - Female
MH  - Humans
MH  - Male
MH  - Nursing/*standards
MH  - *Self Concept
MH  - Social Values
MH  - Stress, Psychological
MH  - Students/*psychology
MH  - United States
MH  - Young Adult
OTO - NOTNLM
OT  - Ethical confidence
OT  - ethical decision making
OT  - nursing students
OT  - professional identity
OT  - professional nursing values
OT  - self-esteem
EDAT- 2012/11/21 06:00
MHDA- 2013/09/24 06:00
CRDT- 2012/11/21 06:00
PHST- 2012/11/21 06:00 [entrez]
PHST- 2012/11/21 06:00 [pubmed]
PHST- 2013/09/24 06:00 [medline]
AID - 0969733012458608 [pii]
AID - 10.1177/0969733012458608 [doi]
PST - ppublish
SO  - Nurs Ethics. 2013 Jun;20(4):479-90. doi: 10.1177/0969733012458608. Epub 2012 Nov 
      19.


PMID- 23166145
OWN - NLM
STAT- MEDLINE
DCOM- 20130522
LR  - 20140430
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 20
IP  - 1
DP  - 2013 Feb
TI  - The importance of moral sensitivity when including persons with dementia in
      qualitative research.
PG  - 30-40
LID - 10.1177/0969733012455564 [doi]
AB  - The aim of this article is to show the importance of moral sensitivity when
      including persons with dementia in research. The article presents and discusses
      ethical challenges encountered when a total of 15 persons with dementia from two 
      nursing homes and seven proxies were included in a qualitative study. The
      examples show that the ethical challenges may be unpredictable. As researchers,
      you participate with the informants in their daily life and in the interviews,
      and it is not possible to plan all that may happen during the research. A
      procedural proposal to an ethical committee at the beginning of a research
      project based on traditional research ethical principles may serve as a
      guideline, but it cannot solve all the ethical problems one faces during the
      research process. Our main argument in this article is, therefore, that moral
      sensitivity is required in addition to the traditional research ethical
      principles throughout the whole process of observing and interviewing the
      respondents.
FAU - Heggestad, Anne Kari T
AU  - Heggestad AK
AD  - Oslo and Akershus University College of Applied Sciences, Norway.
      anne-kari-tolo.heggestad@hioa.no
FAU - Nortvedt, Per
AU  - Nortvedt P
FAU - Slettebo, Ashild
AU  - Slettebo A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121119
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Activities of Daily Living
MH  - Dementia/psychology
MH  - *Ethics, Nursing
MH  - Interviews as Topic
MH  - *Morals
MH  - Nursing Evaluation Research/*ethics
MH  - Nursing Homes
MH  - Nursing Research/*ethics
MH  - Practice Guidelines as Topic
MH  - Professional-Patient Relations/*ethics
EDAT- 2012/11/21 06:00
MHDA- 2013/05/23 06:00
CRDT- 2012/11/21 06:00
PHST- 2012/11/21 06:00 [entrez]
PHST- 2012/11/21 06:00 [pubmed]
PHST- 2013/05/23 06:00 [medline]
AID - 0969733012455564 [pii]
AID - 10.1177/0969733012455564 [doi]
PST - ppublish
SO  - Nurs Ethics. 2013 Feb;20(1):30-40. doi: 10.1177/0969733012455564. Epub 2012 Nov
      19.


PMID- 23166144
OWN - NLM
STAT- MEDLINE
DCOM- 20150202
LR  - 20130805
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 20
IP  - 5
DP  - 2013 Aug
TI  - 'Working behind the scenes'. An ethical view of mental health nursing and
      first-episode psychosis.
PG  - 517-27
LID - 10.1177/0969733012458607 [doi]
AB  - The aim of this study was to explore and reflect upon mental health nursing and
      first-episode psychosis. Seven multidisciplinary focus group interviews were
      conducted, and data analysis was influenced by a grounded theory approach. The
      core category was found to be a process named 'working behind the scenes'. It is 
      presented along with three subcategories: 'keeping the patient in mind',
      'invisible care' and 'invisible network contact'. Findings are illuminated with
      the ethical principles of respect for autonomy and paternalism. Nursing care is
      dynamic, and clinical work moves along continuums between autonomy and
      paternalism and between ethical reflective and non-reflective practice. 'Working 
      behind the scenes' is considered to be in a paternalistic area, containing an
      ethical reflection. Treating and caring for individuals experiencing
      first-episode psychosis demands an ethical awareness and great vigilance by
      nurses. The study is a contribution to reflection upon everyday nursing practice,
      and the conclusion concerns the importance of making invisible work visible.
FAU - Moe, Cathrine
AU  - Moe C
AD  - University of Nordland-School of Professional Studies, Bodoe, Norway.
      esmoe@online.no
FAU - Kvig, Erling I
AU  - Kvig EI
FAU - Brinchmann, Beate
AU  - Brinchmann B
FAU - Brinchmann, Berit S
AU  - Brinchmann BS
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20121119
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Adolescent
MH  - Adult
MH  - Community Mental Health Centers
MH  - Evidence-Based Nursing
MH  - Female
MH  - Focus Groups
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Norway
MH  - *Nurse-Patient Relations
MH  - Nursing Theory
MH  - *Patient-Centered Care
MH  - Psychiatric Nursing/*ethics
MH  - Psychotic Disorders/diagnosis/*nursing/*psychology
MH  - Qualitative Research
MH  - Rural Population
MH  - Secondary Prevention
MH  - Young Adult
OTO - NOTNLM
OT  - Autonomy
OT  - ethics
OT  - first-episode psychosis
OT  - grounded theory
OT  - mental health nursing
OT  - paternalism
EDAT- 2012/11/21 06:00
MHDA- 2015/02/03 06:00
CRDT- 2012/11/21 06:00
PHST- 2012/11/21 06:00 [entrez]
PHST- 2012/11/21 06:00 [pubmed]
PHST- 2015/02/03 06:00 [medline]
AID - 0969733012458607 [pii]
AID - 10.1177/0969733012458607 [doi]
PST - ppublish
SO  - Nurs Ethics. 2013 Aug;20(5):517-27. doi: 10.1177/0969733012458607. Epub 2012 Nov 
      19.


PMID- 23166142
OWN - NLM
STAT- MEDLINE
DCOM- 20130923
LR  - 20130617
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 20
IP  - 4
DP  - 2013 Jun
TI  - Moral sensitivity relating to the application of the code of ethics.
PG  - 470-8
LID - 10.1177/0969733012455563 [doi]
AB  - This study investigated the clinical application of the 2006 Third Revised Korean
      Nurses' Code of Ethics and the moral sensitivity of nurses. A total of 303
      clinical nurses in South Korea participated in the survey in May and June 2011.
      As instruments of this study, we used the 15 statements of the Korean Nurses'
      Code of Ethics and Korean Moral Sensitivity Questionnaire. The mean score for
      application was 3.77 +/- 0.59 (out of 5), and the mean score for moral
      sensitivity was 5.14 +/- 0.55 (out of 7). The correlation coefficient (r) of the 
      application and moral sensitivity was 0.336 (p < 0.001). Nurses who scored high
      on moral sensitivity also scored high on application (t = -5.018, p < 0.001). In 
      clinical settings, educational programmes to develop the moral sensitivity of
      nurses are necessary for improving the application of the code of ethics.
FAU - Kim, Yong-Soon
AU  - Kim YS
AD  - Ajou University, Republic of Korea.
FAU - Kang, Se-Won
AU  - Kang SW
FAU - Ahn, Jeong-Ah
AU  - Ahn JA
LA  - eng
PT  - Journal Article
DEP - 20121119
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Adult
MH  - Attitude of Health Personnel
MH  - *Codes of Ethics
MH  - *Ethics, Nursing
MH  - Female
MH  - Humans
MH  - Korea
MH  - Middle Aged
MH  - *Morals
MH  - Nursing/standards
MH  - Young Adult
OTO - NOTNLM
OT  - Application
OT  - clinical ethics
OT  - codes of ethics
OT  - moral sensitivity
OT  - nursing
EDAT- 2012/11/21 06:00
MHDA- 2013/09/24 06:00
CRDT- 2012/11/21 06:00
PHST- 2012/11/21 06:00 [entrez]
PHST- 2012/11/21 06:00 [pubmed]
PHST- 2013/09/24 06:00 [medline]
AID - 0969733012455563 [pii]
AID - 10.1177/0969733012455563 [doi]
PST - ppublish
SO  - Nurs Ethics. 2013 Jun;20(4):470-8. doi: 10.1177/0969733012455563. Epub 2012 Nov
      19.


PMID- 23166141
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121127
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 6
DP  - 2012
TI  - Protocol for a randomised clinical study comparing the effect of Roux-en-Y
      gastric bypass and sleeve gastrectomy on reactive hypoglycaemia in morbidly obese
      subjects.
LID - 10.1136/bmjopen-2012-002184 [doi]
LID - e002184 [pii]
AB  - INTRODUCTION: Roux-en-Y gastric bypass (RYGB) is the most performed bariatric
      operation. Reactive hypoglycaemia is a frequent late complication occurring in
      about 72% of RYGB patients, which can present with various intensities up to the 
      serious form of neuroglycopaenia. However, it seems to occur also after sleeve
      gastrectomy (SG) although much more rarely. METHODS AND ANALYSIS: A single
      centre, open, 1-year randomised trial to compare the incidence of hypoglycaemia
      after RYGB or SG. A secondary objective is the assessment of the comparative
      ability of the two surgical procedures in determining the improvement or
      normalisation of insulin sensitivity, given the established relevance of insulin 
      resistance in the cardiometabolic syndrome of obesity. ETHICS AND DISSEMINATION: 
      The study will be published and presented to international meetings and, due to
      the safety issue, it will represent a relevant information for national
      healthcare systems. The protocol was approved by the Catholic University Ethical 
      Committee (A1534/CE/2012). Clinicaltrials.gov Registration n. NCT01581801.
FAU - Mingrone, Geltrude
AU  - Mingrone G
AD  - Department of Internal Medicine, Catholic University, Rome, Italy.
FAU - Panunzi, Simona
AU  - Panunzi S
FAU - De Gaetano, Andrea
AU  - De Gaetano A
FAU - Guidone, Caterina
AU  - Guidone C
FAU - Raffaelli, Marco
AU  - Raffaelli M
FAU - Callari, Cosimo
AU  - Callari C
FAU - Lombardi, Pio Celestino
AU  - Lombardi PC
FAU - Bellantone, Rocco
AU  - Bellantone R
LA  - eng
SI  - ClinicalTrials.gov/NCT01581801
PT  - Journal Article
DEP - 20121119
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3533087
EDAT- 2012/11/21 06:00
MHDA- 2012/11/21 06:01
CRDT- 2012/11/21 06:00
PHST- 2012/11/21 06:00 [entrez]
PHST- 2012/11/21 06:00 [pubmed]
PHST- 2012/11/21 06:01 [medline]
AID - bmjopen-2012-002184 [pii]
AID - 10.1136/bmjopen-2012-002184 [doi]
PST - epublish
SO  - BMJ Open. 2012 Nov 19;2(6). pii: bmjopen-2012-002184. doi:
      10.1136/bmjopen-2012-002184. Print 2012.


PMID- 23166140
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121127
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 6
DP  - 2012
TI  - The Treatment of cardiovascular Risk in Primary care using Electronic Decision
      supOrt (TORPEDO) study-intervention development and protocol for a cluster
      randomised, controlled trial of an electronic decision support and quality
      improvement intervention in Australian primary healthcare.
LID - 10.1136/bmjopen-2012-002177 [doi]
LID - e002177 [pii]
AB  - BACKGROUND: Large gaps exist in the implementation of guideline recommendations
      for cardiovascular disease (CVD) risk management. Electronic decision support
      (EDS) systems are promising interventions to close these gaps but few have
      undergone clinical trial evaluation in Australia. We have developed
      HealthTracker, a multifaceted EDS and quality improvement intervention to improve
      the management of CVD risk. METHODS/DESIGN: It is hypothesised that the use of
      HealthTracker over a 12-month period will result in: (1) an increased proportion 
      of patients receiving guideline-indicated measurements of CVD risk factors and
      (2) an increased proportion of patients at high risk will receive
      guideline-indicated prescriptions for lowering their CVD risk. Sixty health
      services (40 general practices and 20 Aboriginal Community Controlled Health
      Services (ACCHSs) will be randomised in a 1:1 allocation to receive either the
      intervention package or continue with usual care, stratified by service type,
      size and participation in existing quality improvement initiatives. The
      intervention consists of point-of-care decision support; a risk communication
      interface; a clinical audit tool to assess performance on CVD-related indicators;
      a quality improvement component comprising peer-ranked data feedback and support 
      to develop strategies to improve performance. The control arm will continue with 
      usual care without access to these intervention components. Quantitative data
      will be derived from cross-sectional samples at baseline and end of study via
      automated data extraction. Detailed process and economic evaluations will also be
      conducted. ETHICS AND DISSEMINATION: The general practice component of the study 
      is approved by the University of Sydney Human Research Ethics Committee (HREC)
      and the ACCHS component is approved by the Aboriginal Health and Medical Research
      Council HREC. Formal agreements with each of the participating sites have been
      signed. In addition to the usual scientific forums, results will be disseminated 
      via newsletters, study websites, face-to-face feedback forums and workshops.
      TRIAL REGISTRATION: The trial is registered with the Australian Clinical Trials
      Registry ACTRN 12611000478910.
FAU - Peiris, David
AU  - Peiris D
AD  - The George Institute for Global Health, Sydney, New South Wales, Australia.
FAU - Usherwood, Tim
AU  - Usherwood T
FAU - Panaretto, Katie
AU  - Panaretto K
FAU - Harris, Mark
AU  - Harris M
FAU - Hunt, Jenny
AU  - Hunt J
FAU - Patel, Bindu
AU  - Patel B
FAU - Zwar, Nicholas
AU  - Zwar N
FAU - Redfern, Julie
AU  - Redfern J
FAU - Macmahon, Stephen
AU  - Macmahon S
FAU - Colagiuri, Stephen
AU  - Colagiuri S
FAU - Hayman, Noel
AU  - Hayman N
FAU - Patel, Anushka
AU  - Patel A
LA  - eng
PT  - Journal Article
DEP - 20121119
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3533097
EDAT- 2012/11/21 06:00
MHDA- 2012/11/21 06:01
CRDT- 2012/11/21 06:00
PHST- 2012/11/21 06:00 [entrez]
PHST- 2012/11/21 06:00 [pubmed]
PHST- 2012/11/21 06:01 [medline]
AID - bmjopen-2012-002177 [pii]
AID - 10.1136/bmjopen-2012-002177 [doi]
PST - epublish
SO  - BMJ Open. 2012 Nov 19;2(6). pii: bmjopen-2012-002177. doi:
      10.1136/bmjopen-2012-002177. Print 2012.


PMID- 23166135
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121127
LR  - 20220318
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 6
DP  - 2012
TI  - The PREVENT study: a prospective cohort study to identify mid-life biomarkers of 
      late-onset Alzheimer's disease.
LID - 10.1136/bmjopen-2012-001893 [doi]
LID - e001893 [pii]
AB  - INTRODUCTION: Epidemiological studies indicate that significant decreases in the 
      incidence of Alzheimer's disease (AD) may be obtained by targeting multiple
      middle-age risk factors. However, as dementia is unlikely to be diagnosed for
      decades, short-term outcome measures are required. AD biomarker changes precede
      clinical symptoms by many years, but their sensitivity to mid-life change remains
      unknown. METHODS AND ANALYSIS: PREVENT is a prospective cohort study examining
      biomarker status at mid-life in at least 150 individuals genetically at high,
      medium or low risk of late-onset AD. Participants are children of individuals
      with or without a diagnosed AD allocated to high, medium and low-risk groups
      according to parental clinical status and ApoE genotype. The biomarkers examined 
      over 2 years are plasma and CSF Abeta42 amyloid, Tau and pTau, proinflammatory
      cytokines, acute-phase proteins, medial temporal-lobe atrophy, white matter
      lesion volume, cognitive performance related to transentorhinal and hippocampal
      functioning and hypothalamic-pituitary-adrenal and sympathetic axes regulation.
      ETHICS AND DISSEMINATION: Detected pathologies are communicated to the
      participant's general practitioner with their permission. Risk status by genotype
      would not be revealed. The results of the study would be published in
      peer-reviewed journals and validated biomarkers used to construct a randomised
      controlled intervention study.
FAU - Ritchie, Craig W
AU  - Ritchie CW
AD  - Centre for Mental Health, Imperial College London, London, UK.
FAU - Ritchie, Karen
AU  - Ritchie K
LA  - eng
PT  - Journal Article
DEP - 20121119
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3533047
EDAT- 2012/11/21 06:00
MHDA- 2012/11/21 06:01
CRDT- 2012/11/21 06:00
PHST- 2012/11/21 06:00 [entrez]
PHST- 2012/11/21 06:00 [pubmed]
PHST- 2012/11/21 06:01 [medline]
AID - bmjopen-2012-001893 [pii]
AID - 10.1136/bmjopen-2012-001893 [doi]
PST - epublish
SO  - BMJ Open. 2012 Nov 19;2(6). pii: bmjopen-2012-001893. doi:
      10.1136/bmjopen-2012-001893. Print 2012.


PMID- 23166123
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121127
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 6
DP  - 2012
TI  - Comparing the validity of the Modified Modified Ashworth Scale (MMAS) and the
      Modified Tardieu Scale (MTS) in the assessment of wrist flexor spasticity in
      patients with stroke: protocol for a neurophysiological study.
LID - 10.1136/bmjopen-2012-001394 [doi]
LID - e001394 [pii]
AB  - INTRODUCTION: Reliable and valid tools must be used to assess spasticity in
      clinical practise and research settings. There is a paucity of literature
      regarding the validity of the Modified Modified Ashworth Scale (MMAS) and the
      Modified Tardieu Scale (MTS). No study, to date, has been performed to compare
      the validity of the MMAS and the MTS. This neurophysiological study protocol will
      compare the validity of the MMAS and the MTS in the assessment of poststroke
      wrist flexor spasticity. METHODS AND ANALYSIS: Thirty-two patients with stroke
      from the University Rehabilitation clinics will be recruited to participate in
      this cross-sectional, non-interventional study. All measurements will be taken in
      the Physical Medicine and Rehabilitation Department of Shafa University Hospital 
      in Tehran, Iran. First, wrist flexor spasticity will be assessed clinically using
      the MMAS and MTS. The tests will be applied randomly. For the MTS, the components
      of R1, R2, R2-R1 and quality of muscle reaction will be measured. Second,
      neurophysiological measures of H-reflex latency, H(max)/M(max) ratio, H(slp) and 
      H(slp)/M(slp) ratio will be collected from the affected side. The results will be
      analysed using Spearman's rho test or Pearson's correlation test to determine the
      validity of the MMAS and the MTS as well as to compare the validity between the
      MMAS and the MTS. ETHICS AND DISSEMINATION: The Research Council, School of
      Rehabilitation and the Ethics Committee of Tehran University of Medical Sciences 
      (TUMS) approved the study protocol. The study results will be disseminated in
      peer-reviewed publications and presented at international congresses.
FAU - Abolhasani, Hamid
AU  - Abolhasani H
AD  - Department of Physiotherapy, School of Rehabilitation, Tehran University of
      Medical Sciences, Tehran, Iran.
FAU - Ansari, Noureddin Nakhostin
AU  - Ansari NN
FAU - Naghdi, Soofia
AU  - Naghdi S
FAU - Mansouri, Korosh
AU  - Mansouri K
FAU - Ghotbi, Nastaran
AU  - Ghotbi N
FAU - Hasson, Scott
AU  - Hasson S
LA  - eng
PT  - Journal Article
DEP - 20121119
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3532966
EDAT- 2012/11/21 06:00
MHDA- 2012/11/21 06:01
CRDT- 2012/11/21 06:00
PHST- 2012/11/21 06:00 [entrez]
PHST- 2012/11/21 06:00 [pubmed]
PHST- 2012/11/21 06:01 [medline]
AID - bmjopen-2012-001394 [pii]
AID - 10.1136/bmjopen-2012-001394 [doi]
PST - epublish
SO  - BMJ Open. 2012 Nov 19;2(6). pii: bmjopen-2012-001394. doi:
      10.1136/bmjopen-2012-001394. Print 2012.


PMID- 23166054
OWN - NLM
STAT- MEDLINE
DCOM- 20130807
LR  - 20200930
IS  - 1552-4833 (Electronic)
IS  - 1552-4825 (Linking)
VI  - 158A
IP  - 12
DP  - 2012 Dec
TI  - Incidental findings in genetic research and clinical diagnostic tests: a
      systematic review.
PG  - 3159-67
LID - 10.1002/ajmg.a.35615 [doi]
AB  - Incidental findings arise when clinically relevant genetic information about a
      research participant or patient is identified outside the scope of the original
      research objective or diagnostic test being performed. These findings can relate 
      to carrier status for a heritable condition, misattributed paternity or increased
      susceptibility to a medical condition. The decision whether to disclose these
      findings to the research subject or patient is underpinned by many ethical,
      moral, and potentially legal considerations. There is an urgent need for
      definitive guidelines for researchers and healthcare professionals. We performed 
      a systematic review of the relevant literature concerning the disclosure of
      incidental findings, based on the Preferred Reporting Items for Systematic
      Reviews and Meta-Analyses recommendations, using the prescribed flowchart and
      checklist. At initial screening, 473 articles were retrieved. The inclusion and
      exclusion criteria aimed at obtaining data that were relevant and of sufficient
      quality were applied and a total of four relevant studies were identified,
      comprising 2,680 individual participants and 1,023 guidance documents. Major
      themes emerging from the included articles include patient autonomy, patient
      welfare, harmful secrets, and genetic literacy. The lack of relevant studies
      emphasizes the urgent need for empirical investigations into the disclosure or
      non-disclosure of genetic incidental findings, and the provision of guidelines to
      assist healthcare professionals and researchers.
CI  - Copyright (c) 2012 Wiley Periodicals, Inc.
FAU - Jackson, Leigh
AU  - Jackson L
AD  - School of Nursing and Midwifery, Plymouth University, Plymouth, UK.
      leigh.jackson@plymouth.ac.uk
FAU - Goldsmith, Lesley
AU  - Goldsmith L
FAU - O'Connor, Anita
AU  - O'Connor A
FAU - Skirton, Heather
AU  - Skirton H
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20121119
PL  - United States
TA  - Am J Med Genet A
JT  - American journal of medical genetics. Part A
JID - 101235741
SB  - IM
MH  - *Genetic Research
MH  - Genetic Testing/*methods
MH  - Humans
MH  - Incidental Findings
EDAT- 2012/11/21 06:00
MHDA- 2013/08/08 06:00
CRDT- 2012/11/21 06:00
PHST- 2011/12/06 00:00 [received]
PHST- 2012/07/20 00:00 [accepted]
PHST- 2012/11/21 06:00 [entrez]
PHST- 2012/11/21 06:00 [pubmed]
PHST- 2013/08/08 06:00 [medline]
AID - 10.1002/ajmg.a.35615 [doi]
PST - ppublish
SO  - Am J Med Genet A. 2012 Dec;158A(12):3159-67. doi: 10.1002/ajmg.a.35615. Epub 2012
      Nov 19.


PMID- 23165706
OWN - NLM
STAT- MEDLINE
DCOM- 20130319
LR  - 20121120
IS  - 1477-8920 (Print)
IS  - 1477-8920 (Linking)
VI  - 10
IP  - 4
DP  - 2012 Dec
TI  - Commentary on community-led total sanitation and human rights: should the right
      to community-wide health be won at the cost of individual rights?
PG  - 499-503
LID - 10.2166/wh.2012.205 [doi]
AB  - The Millennium Development Goals (MDGs) set out to halve the proportion of the
      population without access to basic sanitation between 1990 and 2015. The slow
      pace of progress has lead to a search for innovative responses, including social 
      motivation approaches. One example of this type of approach is 'Community-led
      Total Sanitation' (CLTS). CLTS represents a major shift for sanitation projects
      and programmes in recognising the value of stopping open-defecation across the
      whole community, even when the individual toilets built are not necessarily
      wholly hygienic. However, recent publications on CLTS document a number of
      examples of practices which fail to meet basic ethical criteria and infringe
      human rights. There is a general theme in the CLTS literature encouraging the use
      of 'shame' or 'social stigma' as a tool for promoting behaviours. There are
      reported cases where monetary benefits to which individuals are otherwise
      entitled or the means to practice a livelihood are withheld to create pressures
      to conform. At the very extreme end of the scale, the investigation and
      punishment of violence has reportedly been denied if the crime occurred while
      defecating in the open, violating rights to a remedy and related access to
      justice. While social mobilisation in general, and CLTS in particular, have
      drastically and positively changed the way we think about sanitation, they
      neither need nor benefit from an association with any infringements of human
      rights.
FAU - Bartram, Jamie
AU  - Bartram J
AD  - Department of Environmental Sciences and Engineering, The University of North
      Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. jbartram@email.unc.edu
FAU - Charles, Katrina
AU  - Charles K
FAU - Evans, Barbara
AU  - Evans B
FAU - O'Hanlon, Lucinda
AU  - O'Hanlon L
FAU - Pedley, Steve
AU  - Pedley S
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Water Health
JT  - Journal of water and health
JID - 101185420
SB  - IM
MH  - Community Health Planning/*ethics/legislation & jurisprudence/*standards
MH  - *Developing Countries
MH  - Healthy People Programs/ethics/standards
MH  - *Human Rights/standards
MH  - Humans
MH  - Hygiene/economics/standards
MH  - Public Health/ethics/legislation & jurisprudence/standards
MH  - *Sanitation/ethics/legislation & jurisprudence/standards
MH  - Social Justice
EDAT- 2012/11/21 06:00
MHDA- 2013/03/21 06:00
CRDT- 2012/11/21 06:00
PHST- 2012/11/21 06:00 [entrez]
PHST- 2012/11/21 06:00 [pubmed]
PHST- 2013/03/21 06:00 [medline]
AID - 10.2166/wh.2012.205 [doi]
PST - ppublish
SO  - J Water Health. 2012 Dec;10(4):499-503. doi: 10.2166/wh.2012.205.


PMID- 23165187
OWN - NLM
STAT- MEDLINE
DCOM- 20131210
LR  - 20131021
IS  - 1879-3185 (Electronic)
IS  - 0300-483X (Linking)
VI  - 313
IP  - 1
DP  - 2013 Nov 8
TI  - Applying quantitative structure-activity relationship approaches to
      nanotoxicology: current status and future potential.
PG  - 15-23
LID - 10.1016/j.tox.2012.11.005 [doi]
LID - S0300-483X(12)00397-6 [pii]
AB  - The potential (eco)toxicological hazard posed by engineered nanoparticles is a
      major scientific and societal concern since several industrial sectors (e.g.
      electronics, biomedicine, and cosmetics) are exploiting the innovative properties
      of nanostructures resulting in their large-scale production. Many consumer
      products contain nanomaterials and, given their complex life-cycle, it is
      essential to anticipate their (eco)toxicological properties in a fast and
      inexpensive way in order to mitigate adverse effects on human health and the
      environment. In this context, the application of the structure-toxicity paradigm 
      to nanomaterials represents a promising approach. Indeed, according to this
      paradigm, it is possible to predict toxicological effects induced by chemicals on
      the basis of their structural similarity with chemicals for which toxicological
      endpoints have been previously measured. These structure-toxicity relationships
      can be quantitative or qualitative in nature and they can predict toxicological
      effects directly from the physicochemical properties of the entities (e.g.
      nanoparticles) of interest. Therefore, this approach can aid in prioritizing
      resources in toxicological investigations while reducing the ethical and monetary
      costs that are related to animal testing. The purpose of this review is to
      provide a summary of recent key advances in the field of QSAR modelling of
      nanomaterial toxicity, to identify the major gaps in research required to
      accelerate the use of quantitative structure-activity relationship (QSAR)
      methods, and to provide a roadmap for future research needed to achieve QSAR
      models useful for regulatory purposes.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Winkler, David A
AU  - Winkler DA
AD  - CSIRO Materials Science and Engineering, Clayton, Australia; Monash Institute of 
      Pharmaceutical Science, Parkville, Australia. Electronic address:
      Dave.Winkler@csiro.au.
FAU - Mombelli, Enrico
AU  - Mombelli E
FAU - Pietroiusti, Antonio
AU  - Pietroiusti A
FAU - Tran, Lang
AU  - Tran L
FAU - Worth, Andrew
AU  - Worth A
FAU - Fadeel, Bengt
AU  - Fadeel B
FAU - McCall, Maxine J
AU  - McCall MJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20121116
PL  - Ireland
TA  - Toxicology
JT  - Toxicology
JID - 0361055
SB  - IM
MH  - Animals
MH  - Biomedical Research/methods
MH  - Computer Simulation
MH  - Humans
MH  - Models, Chemical
MH  - *Models, Molecular
MH  - Nanoparticles/*toxicity
MH  - Quantitative Structure-Activity Relationship
MH  - Toxicology/*methods
OTO - NOTNLM
OT  - Chemical category
OT  - Computational toxicology
OT  - Nanotoxicology
OT  - QSAR
OT  - Regulation
EDAT- 2012/11/21 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/11/21 06:00
PHST- 2012/04/11 00:00 [received]
PHST- 2012/11/08 00:00 [revised]
PHST- 2012/11/08 00:00 [accepted]
PHST- 2012/11/21 06:00 [entrez]
PHST- 2012/11/21 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - S0300-483X(12)00397-6 [pii]
AID - 10.1016/j.tox.2012.11.005 [doi]
PST - ppublish
SO  - Toxicology. 2013 Nov 8;313(1):15-23. doi: 10.1016/j.tox.2012.11.005. Epub 2012
      Nov 16.


PMID- 23165103
OWN - NLM
STAT- MEDLINE
DCOM- 20131210
LR  - 20130206
IS  - 1479-666X (Print)
IS  - 1479-666X (Linking)
VI  - 11 Suppl 1
DP  - 2013
TI  - Stapled anopexy as a day surgery procedure: our experience over 400 cases.
PG  - S10-3
LID - 10.1016/j.surge.2012.09.005 [doi]
LID - S1479-666X(12)00098-4 [pii]
AB  - BACKGROUND: In 1988, Longo proposed a new treatment for haemorrhoidal disease. In
      western countries day surgery procedures are becoming more and more common. We
      propose a new protocol for outpatient haemorrhoidopexy. PATIENTS AND METHODS:
      From 2003 to 2010, we performed 403 out-patient stapled haemorrhoidopexies under 
      spinal anaesthesia, on patients with symptomatic grade III and IV haemorrhoid
      disease. We used PPH 01 and PPH 03 staplers (Ethicon Endosurgery, Cincinnati, OH,
      USA). We assessed early and late postoperative pain with a Visual Analogue Scale 
      (VAS), and clinical postoperative examinations were performed 7 days, 6 months,
      and 1, 3 and 5 years after surgery. RESULTS: The mean surgery time was about 20
      min (range 13-39 min). Out of 403 patients, 41 were not dischargeable as a result
      of urine retention, severe pain or mild bleeding. Twenty-two patients reported
      transient faecal urgency, while no patient complained of anal incontinence.
      CONCLUSIONS: Our experience with 403 patients demonstrated that stapled
      haemorrhoidopexy is feasible and safe as a day surgery procedure. However,
      careful preoperative planning is necessary in order to evaluate the patients'
      health status and the consequent perioperative and postoperative risk. Our
      results are positive in terms of surgical safety and postoperative recovery time.
CI  - Copyright (c) 2012 Royal College of Surgeons of Edinburgh (Scottish charity
      number SC005317) and Royal College of Surgeons in Ireland. Published by Elsevier 
      Ltd. All rights reserved.
FAU - Cosenza, Umile Michele
AU  - Cosenza UM
AD  - Department of Medical and Surgical Sciences and Translational Medicine, St.
      Andrea Hospital, School of Medicine and Psychology, University Sapienza of Rome, 
      Rome, Italy. onedaysurgery-info@yahoo.it
FAU - Conte, Stefano
AU  - Conte S
FAU - Mari, Francesco Saverio
AU  - Mari FS
FAU - Nigri, Giuseppe
AU  - Nigri G
FAU - Milillo, Andrea
AU  - Milillo A
FAU - Gasparrini, Marcello
AU  - Gasparrini M
FAU - Pancaldi, Alessandra
AU  - Pancaldi A
FAU - Brescia, Antonio
AU  - Brescia A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20121117
PL  - Scotland
TA  - Surgeon
JT  - The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
JID - 101168329
SB  - IM
MH  - Ambulatory Surgical Procedures/*methods
MH  - Equipment Design
MH  - Female
MH  - Follow-Up Studies
MH  - Hemorrhoidectomy/*methods
MH  - Hemorrhoids/surgery
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - *Surgical Stapling
MH  - Suture Techniques/*instrumentation
MH  - Treatment Outcome
EDAT- 2012/11/21 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/11/21 06:00
PHST- 2012/09/07 00:00 [received]
PHST- 2012/09/28 00:00 [accepted]
PHST- 2012/11/21 06:00 [entrez]
PHST- 2012/11/21 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - S1479-666X(12)00098-4 [pii]
AID - 10.1016/j.surge.2012.09.005 [doi]
PST - ppublish
SO  - Surgeon. 2013;11 Suppl 1:S10-3. doi: 10.1016/j.surge.2012.09.005. Epub 2012 Nov
      17.


PMID- 23164406
OWN - NLM
STAT- MEDLINE
DCOM- 20131118
LR  - 20121120
IS  - 1532-8228 (Electronic)
IS  - 0883-9417 (Linking)
VI  - 26
IP  - 6
DP  - 2012 Dec
TI  - Ethical problems experienced by psychiatric nurses in Korea.
PG  - 495-502
LID - 10.1016/j.apnu.2012.04.002 [doi]
LID - S0883-9417(12)00045-3 [pii]
AB  - This study aimed to explore the ethical problems experienced by psychiatric
      nurses in a clinical setting. Data were collected using semistructured interviews
      with a purposive sample of 12 female psychiatric nurses from 3 psychiatric
      facilities in Korea. A thematic content analysis was used to identify ethical
      problems. The study illustrated 5 categories of ethical problems: moral
      unpreparedness and blindness, moral numbness, moral complacency, moral conflict, 
      and moral stress. This study provides a theoretical basis of psychiatric ethical 
      problems for developing ethical guidelines that will enable psychiatric nurses to
      make decisions reasonably and behave ethically in their workplace.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Choe, Kwisoon
AU  - Choe K
AD  - Department of Nursing, Kunsan National University, Jeollabuk-do, Republic of
      Korea. choe1201@hanmail.net
FAU - Song, Eun-Ju
AU  - Song EJ
FAU - Jung, Chun-Hwa
AU  - Jung CH
LA  - eng
PT  - Journal Article
DEP - 20120612
PL  - United States
TA  - Arch Psychiatr Nurs
JT  - Archives of psychiatric nursing
JID - 8708534
SB  - IM
MH  - Adult
MH  - Decision Making
MH  - *Ethics, Nursing
MH  - Female
MH  - Focus Groups
MH  - Hospitals, Psychiatric/*ethics
MH  - Humans
MH  - *Moral Obligations
MH  - Psychiatric Nursing/*ethics
MH  - Qualitative Research
MH  - Republic of Korea
MH  - *Stress, Psychological
EDAT- 2012/11/21 06:00
MHDA- 2013/11/19 06:00
CRDT- 2012/11/21 06:00
PHST- 2011/08/29 00:00 [received]
PHST- 2012/03/02 00:00 [revised]
PHST- 2012/04/01 00:00 [accepted]
PHST- 2012/11/21 06:00 [entrez]
PHST- 2012/11/21 06:00 [pubmed]
PHST- 2013/11/19 06:00 [medline]
AID - S0883-9417(12)00045-3 [pii]
AID - 10.1016/j.apnu.2012.04.002 [doi]
PST - ppublish
SO  - Arch Psychiatr Nurs. 2012 Dec;26(6):495-502. doi: 10.1016/j.apnu.2012.04.002.
      Epub 2012 Jun 12.


PMID- 23164189
OWN - NLM
STAT- MEDLINE
DCOM- 20130524
LR  - 20211021
IS  - 1557-9840 (Electronic)
IS  - 0095-5108 (Linking)
VI  - 39
IP  - 4
DP  - 2012 Dec
TI  - The mathematics of morality for neonatal resuscitation.
PG  - 941-56
LID - 10.1016/j.clp.2012.09.013 [doi]
LID - S0095-5108(12)00109-1 [pii]
AB  - This article discusses the ethical issues surrounding the resuscitation of
      infants who are at great risk to die or survive with significant morbidity. Data 
      are introduced regarding money, outcomes, and prediction. Gestational age
      influences some of the outcomes after birth more than others do. Prediction is
      possible at four stages of the resuscitation process. Data suggest that antenatal
      and delivery room predictions are inadequate, and prediction at the time of
      discharge is too late. The predictive value (>95%) for the outcome of death or
      survival with neurodevelopmental impairment is discussed.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Meadow, William
AU  - Meadow W
AD  - The University of Chicago, Chicago, IL 60637, USA. wlm1@uchicago.edu
FAU - Lagatta, Joanne
AU  - Lagatta J
FAU - Andrews, Bree
AU  - Andrews B
FAU - Lantos, John
AU  - Lantos J
LA  - eng
GR  - UL1 TR000055/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Clin Perinatol
JT  - Clinics in perinatology
JID - 7501306
SB  - IM
MH  - Cost-Benefit Analysis
MH  - Decision Making
MH  - Humans
MH  - *Infant Mortality
MH  - Infant, Extremely Low Birth Weight
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Intensive Care Units, Neonatal/*economics
MH  - Intuition
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Resuscitation/*economics
MH  - Survival Analysis
PMC - PMC4506790
MID - NIHMS684911
EDAT- 2012/11/21 06:00
MHDA- 2013/05/28 06:00
CRDT- 2012/11/21 06:00
PHST- 2012/11/21 06:00 [entrez]
PHST- 2012/11/21 06:00 [pubmed]
PHST- 2013/05/28 06:00 [medline]
AID - S0095-5108(12)00109-1 [pii]
AID - 10.1016/j.clp.2012.09.013 [doi]
PST - ppublish
SO  - Clin Perinatol. 2012 Dec;39(4):941-56. doi: 10.1016/j.clp.2012.09.013.


PMID- 23163988
OWN - NLM
STAT- MEDLINE
DCOM- 20130503
LR  - 20121120
IS  - 1531-5037 (Electronic)
IS  - 0022-3468 (Linking)
VI  - 47
IP  - 11
DP  - 2012 Nov
TI  - Thirty-day outcome in children randomized to open and laparoscopic Nissen
      fundoplication.
PG  - 1990-6
LID - 10.1016/j.jpedsurg.2012.05.038 [doi]
LID - S0022-3468(12)00488-5 [pii]
AB  - BACKGROUND: Laparoscopic Nissen fundoplication (LNF) is considered by some to be 
      superior to open Nissen fundoplication (ONF). To test this hypothesis, we
      compared early results after LNF and ONF in a randomized trial. METHODS: All
      children accepted for antireflux surgery for gastroesophageal reflux disease were
      offered enrollment. Ethical approval and parental consent were obtained.
      Anesthesia, surgical methods, and postoperative treatment were standardized.
      Patient demographics, length of hospital stay (LOS), and complications occurring 
      the first 30 postoperative days were registered. RESULTS: Eighty-eight children
      were randomized to LNF (n = 44) or ONF (n = 44). The groups were comparable with 
      regard to age, weight, and comorbidity. Duration of surgery was 150 +/- 34
      minutes for LNF and 89 +/- 25 minutes for ONF (P < .001). Median LOS was 7.0 days
      (range, 3-57 days) and 7.5 days (range, 2-20 days) after LNF and ONF,
      respectively (P = .74). Postoperative complications occurred in 48 patients, 24
      in both groups. Twenty-four patients (LNF: n = 12, ONF: n = 11) were readmitted
      to hospital because of complications occurring after discharge. CONCLUSIONS: This
      study failed to show that LNF is superior to ONF when surgery duration, LOS, and 
      complications occurring during the first postoperative month were compared. Apart
      from surgery duration, the results were surprisingly similar.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Knatten, Charlotte K
AU  - Knatten CK
AD  - Faculty of Medicine, University of Oslo, 0316 Oslo, Norway. charlotte@knatten.org
FAU - Fyhn, Thomas J
AU  - Fyhn TJ
FAU - Edwin, Bjorn
AU  - Edwin B
FAU - Schistad, Ole
AU  - Schistad O
FAU - Emblem, Ragnhild
AU  - Emblem R
FAU - Bjornland, Kristin
AU  - Bjornland K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Pediatr Surg
JT  - Journal of pediatric surgery
JID - 0052631
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Fundoplication/*methods
MH  - Gastroesophageal Reflux/*surgery
MH  - Humans
MH  - Infant
MH  - *Laparoscopy
MH  - Length of Stay/statistics & numerical data
MH  - Male
MH  - Operative Time
MH  - Postoperative Complications/epidemiology
MH  - Prospective Studies
MH  - Regression Analysis
MH  - Treatment Outcome
EDAT- 2012/11/21 06:00
MHDA- 2013/05/04 06:00
CRDT- 2012/11/21 06:00
PHST- 2012/02/22 00:00 [received]
PHST- 2012/04/18 00:00 [revised]
PHST- 2012/05/24 00:00 [accepted]
PHST- 2012/11/21 06:00 [entrez]
PHST- 2012/11/21 06:00 [pubmed]
PHST- 2013/05/04 06:00 [medline]
AID - S0022-3468(12)00488-5 [pii]
AID - 10.1016/j.jpedsurg.2012.05.038 [doi]
PST - ppublish
SO  - J Pediatr Surg. 2012 Nov;47(11):1990-6. doi: 10.1016/j.jpedsurg.2012.05.038.


PMID- 23163796
OWN - NLM
STAT- MEDLINE
DCOM- 20140306
LR  - 20211021
IS  - 1399-0004 (Electronic)
IS  - 0009-9163 (Linking)
VI  - 84
IP  - 3
DP  - 2013 Sep
TI  - Perspectives of clinical genetics professionals toward genome sequencing and
      incidental findings: a survey study.
PG  - 230-6
LID - 10.1111/cge.12060 [doi]
AB  - The introduction of clinical genome-wide sequencing raises complex issues
      regarding the management of incidental findings. However, there is a lack of
      empirical studies assessing views of providers involved in potential disclosure
      of such findings. In an anonymous survey of 279 clinical genetics professionals, 
      we found that the vast majority of participants agreed that they were interested 
      in knowing about clinically actionable incidental findings in themselves (96%)
      and their child (99%), and they reported that these types of findings should be
      disclosed in adult (96%) and minor (98%) patients. Approximately three-fourths
      agreed that they were personally interested in knowing about an adult-onset
      clinically actionable disease (78%) and a childhood-onset non-clinically
      actionable disease (75%) in their child. A similar percentage of participants
      (70%) felt that these two types of findings should be disclosed to patients.
      Forty-four percent of participants wanted to know about an incidental finding
      that indicates an adult-onset non-clinically actionable condition in themselves
      and 31% wanted to know about this type of information in their child. Findings
      from this study revealed participants' views highly dependent on clinical
      actionability. Further research is needed with a broader population of
      geneticists to increase generalizability, and with diverse patients to assess
      their perspectives about results disclosure from clinical sequencing.
CI  - (c) 2012 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Lemke, A A
AU  - Lemke AA
AD  - School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705,
      USA. aalemke@tds.net
FAU - Bick, D
AU  - Bick D
FAU - Dimmock, D
AU  - Dimmock D
FAU - Simpson, P
AU  - Simpson P
FAU - Veith, R
AU  - Veith R
LA  - eng
GR  - UL1 TR000055/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121207
PL  - Denmark
TA  - Clin Genet
JT  - Clinical genetics
JID - 0253664
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Child
MH  - Female
MH  - *Genetics, Medical
MH  - *Genomics
MH  - Health Care Surveys
MH  - *Health Knowledge, Attitudes, Practice
MH  - *Health Personnel
MH  - *High-Throughput Nucleotide Sequencing
MH  - Humans
MH  - *Incidental Findings
MH  - Male
MH  - Middle Aged
MH  - Young Adult
PMC - PMC3888159
MID - NIHMS524807
OTO - NOTNLM
OT  - clinical genetics
OT  - ethics
OT  - genetics professionals
OT  - genomic sequencing
OT  - incidental findings
OT  - policy
OT  - return of results
OT  - secondary findings
OT  - whole genome sequencing
EDAT- 2012/11/21 06:00
MHDA- 2014/03/07 06:00
CRDT- 2012/11/21 06:00
PHST- 2012/09/10 00:00 [received]
PHST- 2012/11/08 00:00 [revised]
PHST- 2012/11/08 00:00 [accepted]
PHST- 2012/11/21 06:00 [entrez]
PHST- 2012/11/21 06:00 [pubmed]
PHST- 2014/03/07 06:00 [medline]
AID - 10.1111/cge.12060 [doi]
PST - ppublish
SO  - Clin Genet. 2013 Sep;84(3):230-6. doi: 10.1111/cge.12060. Epub 2012 Dec 7.


PMID- 23163670
OWN - NLM
STAT- MEDLINE
DCOM- 20130708
LR  - 20190902
IS  - 1326-5377 (Electronic)
IS  - 0025-729X (Linking)
VI  - 197
IP  - 10
DP  - 2012 Nov 19
TI  - Gamete donor medical records: whose information is it?
PG  - 543
AB  - Is it ethical, moral and feasible to release gamete donors' medical records to
      conceived offspring?
FAU - Adams, Damian H
AU  - Adams DH
AD  - School of Nursing and Midwifery, Flinders University, Adelaide, SA, Australia.
      damianhadams@yahoo.com.au.
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Med J Aust
JT  - The Medical journal of Australia
JID - 0400714
SB  - IM
MH  - Disclosure/*ethics/legislation & jurisprudence
MH  - *Germ Cells
MH  - Humans
MH  - Privacy/*legislation & jurisprudence
MH  - Tissue Donors/*ethics/legislation & jurisprudence
MH  - Victoria
EDAT- 2012/11/21 06:00
MHDA- 2013/07/09 06:00
CRDT- 2012/11/21 06:00
PHST- 2012/11/21 06:00 [entrez]
PHST- 2012/11/21 06:00 [pubmed]
PHST- 2013/07/09 06:00 [medline]
AID - 10.5694/mja12.10851 [pii]
AID - 10.5694/mja12.10851 [doi]
PST - ppublish
SO  - Med J Aust. 2012 Nov 19;197(10):543. doi: 10.5694/mja12.10851.


PMID- 23139174
OWN - NLM
STAT- MEDLINE
DCOM- 20130311
LR  - 20220309
IS  - 1120-9763 (Print)
IS  - 1120-9763 (Linking)
VI  - 36
IP  - 5 Suppl 3
DP  - 2012 Sep-Oct
TI  - [Health technology assessment report: Computer-assisted Pap test for cervical
      cancer screening].
PG  - e1-43
AB  - HEALTH PROBLEM: Cervical cancer is a disease which is highly preventable by means
      of Pap test screening for the precancerous lesions, which can be easily treated. 
      Furthermore, in the near future, control of the disease will be enhanced by the
      vaccination which prevents the infection of those human papillomavirus types that
      cause the vast majority of cervical cancers. The effectiveness of screening in
      drastically reducing cervical cancer incidence has been clearly demonstrated. The
      epidemiology of cervical cancer in industrialised countries is now determined
      mostly by the Pap test coverage of the female population and by the ability of
      health systems to assure appropriate follow up after an abnormal Pap test.
      TECHNOLOGY DESCRIPTION: Today there are two fully automated systems for
      computer-assisted Pap test: the BD FocalPoint and the Hologic Imager. Recently,
      the Hologic Integrated Imager, a semi-automated system, was launched. The two
      fully automated systems are composed of a central scanner, where the machine
      examines the cytologic slide, and of one or more review stations, where the
      cytologists analyze the slides previously centrally scanned. The softwares used
      by the two systems identify the fields of interest so that the cytologists can
      look only at those points, automatically pointed out by the review station.
      Furthermore, the FocalPoint system classifies the slides according to their level
      of risk of containing signs of relevant lesions. Those in the upper
      classes--about one fifth of the slides--are labelled as << further review >>,
      while those in the lower level of risk, i.e. slides that have such a low level of
      risk that they can be considered as negative with no human review, are labelled
      as << no further review >>. The aim of computer-assisted Pap test is to reduce
      the time of slide examination and to increase productivity. Furthermore, the
      number of errors due to lack of attention may decrease. Both the systems can be
      applied to liquidbased cytology, while only the BD Focal Point can be used on
      conventional smears. BACKGROUND: Cytology screening has some critical points:
      there is a shortage of cytologists/cytotechnicians; the quality strongly depends 
      on the experience and ability of the cytologist; there is a subjective component 
      in the cytological diagnosis; in highly screened populations, the prevalence of
      lesions is very low and the activity of cytologists is very monotonous. On the
      other hand, a progressive shift to molecular screening using HPV-DNA test as
      primary screening test is very likely in the near future; cytology will be used
      as triage test, dramatically reducing the number of slides to process and
      increasing the prevalence of lesions in those Pap tests. OBJECTIVES: In this
      Report we assume that the diagnostic accuracy of computer-assisted Pap test is
      equal to the accuracy of manual Pap test and, consequently, that screening using 
      computer-assisted Pap test has the same efficacy in reducing cervical cancer
      incidence and mortality. Under this assumption, the effectiveness/
      benefit/utility is the same for the two screening modes, i.e. the economic
      analysis will be a cost minimization study. Furthermore, the screening process is
      identical for the two modalities in all the phases except for slide
      interpretation. The cost minimization analysis will be limited to the only phase 
      differing between the two modes, i.e. the study will be a differential cost
      analysis between a labour-intensive strategy (traditional Pap test) and a
      technology-intensive strategy (the computer-assisted Pap test). Briefly, the
      objectives of this HTA Report are: to determine the break even point of
      computer-assisted Pap test systems, i.e. the volume of slides processed per year 
      at which putting in place a computer-assisted Pap test system becomes
      economically convenient; to quantify the cost per Pap test in different scenarios
      according to screening centre activity volume, productivity of cytologist, type
      of cytology (conventional smear or liquid-based, fully automated or
      semi-automated computer-assisted); to analyse the computer-assisted Pap test in
      the Italian context, through a survey of the centres using the technology,
      collecting data useful for the sensitivity analysis of the economic evaluation;
      to evaluate the acceptability of the technology in the screening services; to
      evaluate the organizational and financial impact of the computer-assisted Pap
      test in different scenarios; to illustrate the ideal organization to implement
      computer-assisted Pap test in terms of volume of activity, productivity, and
      human and technological resources. PHASES OF THE ASSESSMENT: to produce this
      Report, the following process was adopted: application to the Ministry of health 
      for a grant << Analysis of the impact of professional involvement in evidence
      generation for the HTA process >>; within this project, the sub-project << Cost
      effectiveness evaluation of the computer-assisted Pap test in the Italian
      screening programmes >> was financed; constitution of the Working Group, which
      included the project coordinator, the principal investigator, and the health
      economist; identification of the centres using the computer-assisted Pap test and
      which had published scientific reports on the subject; identification of the
      Consulting Committee (stakeholder), which included screening programmes managers,
      pathologists, economists, health policy-makers, citizen organizations, and
      manufacturers. Once the evaluation was concluded, a plenary meeting with Working 
      Group and Consulting Committee was held. The working group drafted the final
      version of this Report, which took into account the comments received. RESULTS
      AND CONCLUSIONS: the fully automated computer-assisted Pap test has an important 
      financial and organizational impact on screening programmes. The assessment of
      this health technology reached the following conclusions: according to the survey
      results, after some distrust, cytologists accepted the use of the machine and
      appreciated the reduction in interpretation time and the reliability in
      identifying the fields of interest; from an economic point of view, the automated
      computer-assisted Pap test can be convenient only with conventional smears if the
      screening centre has a volume of more than 49,000 slides/year and the cytologist 
      productivity increases about threefold. It must be highlighted that it is not
      sufficient to adopt the automated Pap test to reach such an increase in
      productivity; the laboratory must be organised or re-organised to optimise the
      use of the review stations and the person time. In the case of liquid-based
      cytology, the adoption of automated computer- assisted Pap test can only increase
      the costs. In fact, liquid-based cytology increases the cost of consumable
      materials but reduces the interpretation time, even in manual screening.
      Consequently, the reduction of human costs is smaller in the case of
      computer-assisted screening. Liquid-based cytology has other implications and
      advantages not linked to the use of computer-assisted Pap test that should be
      taken into account and are beyond the scope of this Report; given that the
      computer-assisted Pap test reduces human costs, it may be more advantageous where
      the cost of cytologists is higher; given the relatively small volume of activity 
      of screening centres in Italy, computer-assisted Pap test may be reasonable for a
      network using only one central scanner and several remote review stations; the
      use of automated computer-assisted Pap test only for quality control in a single 
      centre is not economically sustainable. In this case as well, several centres,
      for example at the regional level, may form a consortium to reach a reasonable
      number of slides to achieve the break even point. Regarding the use of a machine 
      rather than human intelligence to interpret the slides, some ethical issues were 
      initially raised, but both the scientific community and healthcare professionals 
      have accepted this technology. The identification of fields of interest by the
      machine is highly reproducible, reducing subjectivity in the diagnostic process. 
      The Hologic system always includes a check by the human eye, while the FocalPoint
      system identifies about one fifth of the slides as No Further Review. Several
      studies, some of which conducted in Italy, confirmed the reliability of this
      classification. There is still some resistance to accept the practice of No
      Further Review. A check of previous slides and clinical data can be useful to
      make the cytologist and the clinician more confident. RECOMMENDATIONS:
      Computer-assisted automated Pap test may be introduced only if there is a need to
      increase the volume of slides screened to cover the screening target population
      and sufficient human resources are not available. Switching a programme using
      conventional slides to automatic scanning can only lead to a reduction in costs
      if the volume of slides per year exceeds 49,000 slides/annum and cytologist
      productivity is optimised to more than 20,000 slides per year. At a productivity 
      of 15,000 or fewer, the automated computer-assisted Pap test cannot be
      convenient. Switching from manual screening with conventional slides to automatic
      scanning with liquid-based cytology cannot generate any economic saving, but the 
      system could increase output with a given number of staff. The transition from
      manual to computer assisted automated screening of liquid based cytology will not
      generate savings and the increase in productivity will be lower than that of the 
      switch from manual/conventional to automated/conventional. The use of biologists 
      or pathologists as cytologists is more costly than the use of cytoscreeners.
      Given that the automated computer-assisted Pap test reduces human resource costs,
      its adoption in a model using only biologists and pathologists for screening is
      more economically advantageous. (ABSTRACT TRUNCATED)
FAU - Della Palma, Paolo
AU  - Della Palma P
AD  - UO Anatomia Patologica, Azienda Provinciale per i Servizi Sanitari, Trento.
      paolo.dallapalma@apss.tn.it
FAU - Moresco, Luca
AU  - Moresco L
FAU - Giorgi Rossi, Paolo
AU  - Giorgi Rossi P
LA  - ita
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
TT  - Health technology assessment report: Pap test con lettura computer-assistita per 
      lo screening del cervicocarcinoma.
PL  - Italy
TA  - Epidemiol Prev
JT  - Epidemiologia e prevenzione
JID - 8902507
SB  - IM
MH  - *Biomedical Technology/economics
MH  - Cost-Benefit Analysis
MH  - *Early Detection of Cancer/economics
MH  - Female
MH  - Humans
MH  - *Image Processing, Computer-Assisted/economics
MH  - Italy/epidemiology
MH  - Reproducibility of Results
MH  - *Technology Assessment, Biomedical
MH  - Uterine Cervical Neoplasms/*diagnosis/economics/epidemiology/pathology
MH  - *Vaginal Smears/economics
EDAT- 2012/11/21 06:00
MHDA- 2013/03/12 06:00
CRDT- 2012/11/10 06:00
PHST- 2012/11/10 06:00 [entrez]
PHST- 2012/11/21 06:00 [pubmed]
PHST- 2013/03/12 06:00 [medline]
AID - 1510 [pii]
PST - ppublish
SO  - Epidemiol Prev. 2012 Sep-Oct;36(5 Suppl 3):e1-43.


PMID- 23139163
OWN - NLM
STAT- MEDLINE
DCOM- 20130311
LR  - 20181202
IS  - 1120-9763 (Print)
IS  - 1120-9763 (Linking)
VI  - 36
IP  - 5 Suppl 2
DP  - 2012 Sep-Oct
TI  - [Health technology assessment report. Use of liquid-based cytology for cervical
      cancer precursors screening].
PG  - e1-e33
AB  - OBJECTIVE OF THE PROJECT: Purpose of this Report is to evaluate the impact of the
      introduction of liquid-based cytology (LBC) in cervical cancer screening in terms
      of efficacy, undesired effects, costs and implications for organisation. EFFICACY
      AND UNDESIRED EFFECTS: LBC WITH MANUAL INTERPRETATION: The estimates of
      cross-sectional accuracy for high-grade intraepithelial neoplasia (CIN2 or more
      severe and CIN3 or more severe) obtained by a systematic review and meta-analysis
      published in 2008 were used. This review considered only studies in which all
      women underwent colposcopy or randomised controlled trials (RCTs) with complete
      verification of test positives. A systematic search of RCTs published thereafter 
      was performed. Three RCTs were identified. One of these studies was conducted in 
      6 Italian regions and was of large size (45,174 women randomised); a second one
      was conducted in another Italian region (Abruzzo) and was of smaller size (8,654 
      women randomised); a third RCT was conducted in the Netherlands and was of large 
      size (89,784 women randomised). No longitudinal study was available. There is
      currently no clear evidence that LBC increases the sensitivity of cytology and
      even less that its introduction increases the efficacy of cervical screening in
      preventing invasive cancers. The Italian randomised study NTCC showed a decrease 
      in specificity, which was not observed in the other two RCTs available. In
      addition, the 2008 meta-analysis observed a reduction - even if minimal - in
      specificity just at the ASC-US cytological cut-off, but also a remarkable
      heterogeneity between studies. These results suggest that the effect of LBC on
      specificity is variable and plausibly related to the local style of cytology
      interpretation. There is evidence that LBC reduces the proportion of
      unsatisfactory slides, although the size of this effect varies remarkably. LBC
      WITH COMPUTER-ASSISTED INTERPRETATION: An Australian study, based on double
      testing, showed a statistically significant increase of the sensitivity for CIN2 
      or more of LBC with computer-assisted interpretation vs. conventional cytology
      with manual interpretation. However, an English RCT estimated that LBC with
      computer-assisted interpretation has a lower sensitivity than LBC with manual
      interpretation. COST AND ECONOMIC EVALUATION: In the current Italian situation
      the use of liquid-based cytology for primary screening is estimated to increase
      the costs of cytological screening. Liquid-based cytology needs shorter time for 
      interpretation than conventional cytology. However, in the Italian situation,
      savings obtained from this time reduction and from the decreased number of
      repeats due to unsatisfactory slides are not currently sufficient to compensate
      the cost increase due to the prices currently applied by producers and to a
      possible greater number of colposcopies caused by LBC. In any case, at current
      prices, cost is estimated to increase even when assuming a referral rate to
      colposcopy with LBC similar or slightly lower than that with conventional
      cytology. For the costs of computer-assisted interpretation of liquid-based
      cytology, readers are referred to the relative HTA report (Epidemiol Prev
      2012;36(5) Suppl 3:e1-43). ORGANISATIONAL AND ETHICAL ASPECTS: Ethical, legal and
      communication problems are judged to remain unchanged when compared to screening 
      with conventional cytology. After having used the test for some time,
      interpreters prefer liquid-based to conventional cytology. Reduced time for
      interpretation makes the adoption of LBC a possible approach to deal with
      shortenings of cytology interpreters which is happening in Italy. However,
      alternative solutions, such as computer-assisted interpretation of cytology and
      the use of HPV as primary screening test, should be considered. Liquid-based
      cytology allows performing molecular tests, in particular the HPV test. This
      property allows triaging women with borderline or mild cytology by "reflex"
      molecular or immunocytochemical tests with no need to recall them. LBC sampling
      can be used also if HPV is applied as the primary screening test, allowing
      "reflex" triaging of HPV positive women by cytology with no need to recall them
      nor to take two samples, one for HPV testing and one for conventional cytology.
      This represents a remarkable advantage in terms of organization. However, costs
      are high because only 5-7% of women screened with this approach need
      interpretation of cytology. In addition, HPV testing with the Hybrid Capture
      assay on material preserved in LBC transport media needs a preliminary conversion
      phase, which limits the use of LBC for triaging HPV positive women. It is
      advisable that in the near future industry develops sampling/transport systems
      that allow performing both the HPV test and cytology or other validated triage
      tests without additional manipulations and at sustainable costs.
FAU - Ronco, Guglielmo
AU  - Ronco G
AD  - Centro di riferimento per l'epidemiologia e la prevenzione oncologica in
      Piemonte. Via San Francesco da Paola 31, Turin.
FAU - Confortini, Massimo
AU  - Confortini M
FAU - Maccallini, Vincenzo
AU  - Maccallini V
FAU - Naldoni, Carlo
AU  - Naldoni C
FAU - Segnan, Nereo
AU  - Segnan N
FAU - Sideri, Mario
AU  - Sideri M
FAU - Zappa, Marco
AU  - Zappa M
FAU - Zorzi, Manuel
AU  - Zorzi M
FAU - Calvia, Maria
AU  - Calvia M
FAU - Giorgi Rossi, Paolo
AU  - Giorgi Rossi P
LA  - ita
PT  - Journal Article
PT  - Review
PT  - Systematic Review
TT  - Health Technology assessment Report. Uso della citologia in fase liquida nello
      screening dei precursori del cancro del collo uterino.
PL  - Italy
TA  - Epidemiol Prev
JT  - Epidemiologia e prevenzione
JID - 8902507
SB  - IM
MH  - Alphapapillomavirus
MH  - Cervical Intraepithelial Neoplasia/*diagnosis/epidemiology/virology
MH  - Colposcopy/economics
MH  - Cost-Benefit Analysis
MH  - Cross-Sectional Studies
MH  - Cytological Techniques/economics
MH  - Early Detection of Cancer
MH  - Female
MH  - Humans
MH  - Italy/epidemiology
MH  - Mass Screening
MH  - Meta-Analysis as Topic
MH  - Papillomavirus Infections/complications/*diagnosis/economics/virology
MH  - Predictive Value of Tests
MH  - Randomized Controlled Trials as Topic
MH  - Sensitivity and Specificity
MH  - Uterine Cervical Neoplasms/*diagnosis/epidemiology/virology
MH  - Vaginal Smears/economics/*methods
EDAT- 2012/11/21 06:00
MHDA- 2013/03/12 06:00
CRDT- 2012/11/10 06:00
PHST- 2012/11/10 06:00 [entrez]
PHST- 2012/11/21 06:00 [pubmed]
PHST- 2013/03/12 06:00 [medline]
AID - 1509 [pii]
PST - ppublish
SO  - Epidemiol Prev. 2012 Sep-Oct;36(5 Suppl 2):e1-e33.


PMID- 23124503
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20121105
IS  - 1548-6869 (Electronic)
IS  - 1049-2089 (Linking)
VI  - 23
IP  - 4 Suppl
DP  - 2012 Nov
TI  - Head and neck cancer disparity in underserved communities: probable causes and
      the ethics involved.
PG  - 88-103
LID - 10.1353/hpu.2012.0165 [doi]
AB  - Head and neck cancers are a cause of morbidity and mortality throughout the
      United States. For low-income, African American men they are one of the leading
      causes of excess cancer deaths: although all racial/ethnic groups suffer from
      these cancers, African American men disproportionately suffer and die from them. 
      Low-income communities have increased risks for many adverse health conditions
      because of environmental factors and existing social determinants of health.
      These social determinants often lead to unhealthy life circumstances and
      ineffective coping behaviors. Early detection enhances effective treatment
      options, but such services are limited among African Americans, particularly
      African American men in underserved areas. Not addressing oral cancer because of 
      these social conditions reflects unjust and unethical behavior by health care
      professionals. In Atlanta, one high-density, limited-resource area has the
      highest incidence of oral cavity cancers. Health Education, Assessment and
      Leadership (HEAL) was created to address the oral cancer incidence and
      prevalence, an example of a preventable health disparity between this underserved
      region and surrounding communities.
FAU - Moore, Charles E
AU  - Moore CE
AD  - Department of Otolaryngology, Emory Healthcare, Emory University, Atlanta, GA
      30322, USA. cemoore@emory.edu
FAU - Warren, Rueben
AU  - Warren R
FAU - Maclin, Sandy D Jr
AU  - Maclin SD Jr
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Health Care Poor Underserved
JT  - Journal of health care for the poor and underserved
JID - 9103800
SB  - IM
MH  - Adult
MH  - African Americans/*statistics & numerical data
MH  - Female
MH  - Georgia/epidemiology
MH  - Head and Neck Neoplasms/*ethnology/prevention & control
MH  - *Health Status Disparities
MH  - Healthcare Disparities/ethics/ethnology
MH  - Humans
MH  - Male
MH  - *Medically Underserved Area
EDAT- 2012/11/21 06:00
MHDA- 2013/02/13 06:00
CRDT- 2012/11/06 06:00
PHST- 2012/11/06 06:00 [entrez]
PHST- 2012/11/21 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
AID - S154868691240050X [pii]
AID - 10.1353/hpu.2012.0165 [doi]
PST - ppublish
SO  - J Health Care Poor Underserved. 2012 Nov;23(4 Suppl):88-103. doi:
      10.1353/hpu.2012.0165.


PMID- 23124502
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20220408
IS  - 1548-6869 (Electronic)
IS  - 1049-2089 (Linking)
VI  - 23
IP  - 4 Suppl
DP  - 2012 Nov
TI  - Community health workers support community-based participatory research ethics:
      lessons learned along the research-to-practice-to-community continuum.
PG  - 77-87
LID - 10.1353/hpu.2012.0156 [doi]
AB  - Ethical principles of community-based participatory research
      (CBPR)--specifically, community engagement, mutual learning, action-reflection,
      and commitment to sustainability--stem from the work of Kurt Lewin and Paulo
      Freire. These are particularly relevant in cancer disparities research because
      vulnerable populations are often construed to be powerless, supposedly benefiting
      from programs over which they have no control. The long history of exploiting
      minority individuals and communities for research purposes (the U.S. Public
      Health Service Tuskegee Syphilis Study being the most notorious) has left a
      legacy of mistrust of research and researchers. The purpose of this article is to
      examine experiences and lessons learned from community health workers (CHWs) in
      the 10-year translation of an educational intervention in the
      research-to-practice-to-community continuum. We conclude that the central role
      played by CHWs enabled the community to gain some degree of control over the
      intervention and its delivery, thus operationalizing the ethical principles of
      CBPR.
FAU - Smith, Selina A
AU  - Smith SA
AD  - Morehouse School of Medicine, 720 Westview Drive, SW, Atlanta, GA 30310, USA.
      ssmith@msm.edu
FAU - Blumenthal, Daniel S
AU  - Blumenthal DS
LA  - eng
GR  - U54CA118638/CA/NCI NIH HHS/United States
GR  - U54 MD007588/MD/NIMHD NIH HHS/United States
GR  - U54 CA118638/CA/NCI NIH HHS/United States
GR  - 5U48DP000049/DP/NCCDPHP CDC HHS/United States
GR  - R01 CA166785/CA/NCI NIH HHS/United States
GR  - U48DP001907/DP/NCCDPHP CDC HHS/United States
GR  - U01 CA114652/CA/NCI NIH HHS/United States
GR  - UL1 TR000454/TR/NCATS NIH HHS/United States
GR  - 5UL1RR025008/RR/NCRR NIH HHS/United States
GR  - U48 DP000049-01/DP/NCCDPHP CDC HHS/United States
GR  - UL1 RR025008/RR/NCRR NIH HHS/United States
GR  - 1R01CA166785-01/CA/NCI NIH HHS/United States
GR  - U54 CA118623/CA/NCI NIH HHS/United States
GR  - U48 DP000049/DP/NCCDPHP CDC HHS/United States
GR  - U54 CA118948/CA/NCI NIH HHS/United States
GR  - DP000049-01/DP/NCCDPHP CDC HHS/United States
GR  - U01CA114652/CA/NCI NIH HHS/United States
GR  - U48 DP001907/DP/NCCDPHP CDC HHS/United States
GR  - G12 MD007585/MD/NIMHD NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Health Care Poor Underserved
JT  - Journal of health care for the poor and underserved
JID - 9103800
SB  - IM
MH  - African Americans/*education/statistics & numerical data
MH  - *Attitude of Health Personnel
MH  - Colorectal Neoplasms/ethnology
MH  - Community Health Workers/*psychology/statistics & numerical data
MH  - Community-Based Participatory Research/*ethics/organization & administration
MH  - Community-Institutional Relations
MH  - Early Detection of Cancer/statistics & numerical data
MH  - Female
MH  - Healthcare Disparities/ethnology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Professional Role
PMC - PMC3586526
MID - NIHMS442870
EDAT- 2012/11/21 06:00
MHDA- 2013/02/13 06:00
CRDT- 2012/11/06 06:00
PHST- 2012/11/06 06:00 [entrez]
PHST- 2012/11/21 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
AID - S1548686912400493 [pii]
AID - 10.1353/hpu.2012.0156 [doi]
PST - ppublish
SO  - J Health Care Poor Underserved. 2012 Nov;23(4 Suppl):77-87. doi:
      10.1353/hpu.2012.0156.


PMID- 23124500
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20211021
IS  - 1548-6869 (Electronic)
IS  - 1049-2089 (Linking)
VI  - 23
IP  - 4 Suppl
DP  - 2012 Nov
TI  - Ethics of clear health communication: applying the CLEAN Look approach to
      communicate biobanking information for cancer research.
PG  - 58-66
LID - 10.1353/hpu.2012.0192 [doi]
AB  - Cancer innovations, such as biobanking technologies, are continuously evolving to
      improve our understanding and knowledge about cancer prevention and treatment
      modalities. However, the public receives little communication about biobanking
      and is often unaware about this innovation until asked to donate biospecimens. It
      is the researchers' ethical duty to provide clear communications about biobanking
      and biospecimen research. Such information allows the public to understand
      biobanking processes and facilitates informed decision making about biospecimen
      donation. The aims of this paper are 1) to examine the importance of clear
      communication as an ethical imperative when conveying information about cancer
      innovations and 2) to illustrate the use of an organizing framework, the CLEAN ( 
      C ulture, L iteracy, E ducation, A ssessment, and N etworking) Look approach for 
      creating educational priming materials about the topic of biobanking.
FAU - Koskan, Alexis
AU  - Koskan A
AD  - Department of Health Outcomes and Behavior, Moffitt Cancer Center, 12902 Magnolia
      Drive, Tampa, FL 33612, USA.
FAU - Arevalo, Mariana
AU  - Arevalo M
FAU - Gwede, Clement K
AU  - Gwede CK
FAU - Quinn, Gwendolyn P
AU  - Quinn GP
FAU - Noel-Thomas, Shalewa A
AU  - Noel-Thomas SA
FAU - Luque, John S
AU  - Luque JS
FAU - Wells, Kristen J
AU  - Wells KJ
FAU - Meade, Cathy D
AU  - Meade CD
LA  - eng
GR  - P30 CA076292/CA/NCI NIH HHS/United States
GR  - R25 CA090314/CA/NCI NIH HHS/United States
GR  - U01 CA114627/CA/NCI NIH HHS/United States
GR  - 3 U01CA114627-05S2/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Health Care Poor Underserved
JT  - Journal of health care for the poor and underserved
JID - 9103800
SB  - IM
MH  - *Biomedical Research
MH  - Health Communication/*ethics/methods
MH  - Humans
MH  - *Neoplasms
MH  - Pamphlets
MH  - *Tissue Banks
MH  - Videodisc Recording
PMC - PMC3735435
MID - NIHMS472606
EDAT- 2012/11/21 06:00
MHDA- 2013/02/13 06:00
CRDT- 2012/11/06 06:00
PHST- 2012/11/06 06:00 [entrez]
PHST- 2012/11/21 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
AID - S154868691240047X [pii]
AID - 10.1353/hpu.2012.0192 [doi]
PST - ppublish
SO  - J Health Care Poor Underserved. 2012 Nov;23(4 Suppl):58-66. doi:
      10.1353/hpu.2012.0192.


PMID- 23124499
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20121105
IS  - 1548-6869 (Electronic)
IS  - 1049-2089 (Linking)
VI  - 23
IP  - 4 Suppl
DP  - 2012 Nov
TI  - HPV, oropharyngeal cancer, and the role of the dentist: a professional ethical
      approach.
PG  - 47-57
LID - 10.1353/hpu.2012.0185 [doi]
AB  - Human papillomavirus (HPV) is an emerging risk factor for oropharyngeal cancer,
      especially among younger patients, and must be thoughtfully addressed by the
      dental community. The professional ethical decision-making model first advanced
      by Ozar and Sokol for use by dentists at chairside (define the dilemma, assess
      the facts, identify and rank the alternatives, and choose a course of action) was
      modified to delineate clearly inputs, considerations, and feedback loops based on
      what is professionally and ethically at stake in advising patients. As the link
      between HPV and oropharyngeal cancer is established through scientific studies,
      the role of the dentist in primary and secondary prevention will be crucial. In
      the absence of definitive evidence, the professional ethical decision-making
      framework presented here allows dentists to systematically work through available
      alternatives. Ultimately, the role of the dentist is to use discretion in
      choosing a professional and ethical course of action for each patient.
FAU - Northridge, Mary E
AU  - Northridge ME
AD  - Department of Epidemiology and Health Promotion, New York University College of
      Dentistry, New York, NY, USA. men6@nyu.edu
FAU - Manji, Naila
AU  - Manji N
FAU - Piamonte, Romney T
AU  - Piamonte RT
FAU - More, Frederick G
AU  - More FG
FAU - Katz, Ralph V
AU  - Katz RV
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Health Care Poor Underserved
JT  - Journal of health care for the poor and underserved
JID - 9103800
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Decision Making/ethics
MH  - Dentists/*ethics/psychology
MH  - *Ethics, Dental
MH  - Female
MH  - Humans
MH  - Male
MH  - Models, Psychological
MH  - Oropharyngeal Neoplasms/prevention & control/*virology
MH  - Papillomavirus Infections/*complications
MH  - *Professional Role
MH  - Young Adult
EDAT- 2012/11/21 06:00
MHDA- 2013/02/13 06:00
CRDT- 2012/11/06 06:00
PHST- 2012/11/06 06:00 [entrez]
PHST- 2012/11/21 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
AID - S1548686912400468 [pii]
AID - 10.1353/hpu.2012.0185 [doi]
PST - ppublish
SO  - J Health Care Poor Underserved. 2012 Nov;23(4 Suppl):47-57. doi:
      10.1353/hpu.2012.0185.


PMID- 23124498
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20211021
IS  - 1548-6869 (Electronic)
IS  - 1049-2089 (Linking)
VI  - 23
IP  - 4 Suppl
DP  - 2012 Nov
TI  - Individual breast cancer risk assessment in underserved populations: integrating 
      empirical bioethics and health disparities research.
PG  - 34-46
LID - 10.1353/hpu.2012.0178 [doi]
AB  - Research suggests that individual breast cancer risk assessment may improve
      adherence to recommended screening and prevention guidelines, thereby decreasing 
      morbidity and mortality. Further research on the use of risk assessment models in
      underserved minority populations is critical to informing national public health 
      efforts to eliminate breast cancer disparities. However, implementing individual 
      breast cancer risk assessment in underserved patient populations raises
      particular ethical issues that require further examination. After reviewing these
      issues, we will discuss how empirical bioethics research can be integrated with
      health disparities research to inform the translation of research findings. Our
      in-progress National Cancer Institute (NCI) funded study, How Do Underserved
      Minority Women Think About Breast Cancer?, conducted in the context of a larger
      study on individual breast cancer risk assessment, is presented as a model.
FAU - Anderson, Emily E
AU  - Anderson EE
AD  - Neiswanger Institute for Bioethics at Loyola University Chicago, Stritch School
      of Medicine, Chicago, IL, USA. emanderson@lumc.edu
FAU - Hoskins, Kent
AU  - Hoskins K
LA  - eng
GR  - P50 CA106743/CA/NCI NIH HHS/United States
GR  - 2P50CA106743/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Health Care Poor Underserved
JT  - Journal of health care for the poor and underserved
JID - 9103800
SB  - IM
MH  - Adult
MH  - Aged
MH  - Attitude to Health/*ethnology
MH  - Bioethics
MH  - Breast Neoplasms/*ethnology
MH  - Early Detection of Cancer
MH  - Empirical Research
MH  - Female
MH  - Health Services Research/*organization & administration
MH  - Healthcare Disparities/ethnology
MH  - Humans
MH  - Middle Aged
MH  - Minority Groups/*psychology
MH  - Risk Assessment/ethics
MH  - United States
MH  - Vulnerable Populations/*ethnology/psychology
PMC - PMC3826177
MID - NIHMS522326
EDAT- 2012/11/21 06:00
MHDA- 2013/02/13 06:00
CRDT- 2012/11/06 06:00
PHST- 2012/11/06 06:00 [entrez]
PHST- 2012/11/21 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
AID - S1548686912400456 [pii]
AID - 10.1353/hpu.2012.0178 [doi]
PST - ppublish
SO  - J Health Care Poor Underserved. 2012 Nov;23(4 Suppl):34-46. doi:
      10.1353/hpu.2012.0178.


PMID- 23124497
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20211021
IS  - 1548-6869 (Electronic)
IS  - 1049-2089 (Linking)
VI  - 23
IP  - 4 Suppl
DP  - 2012 Nov
TI  - Tuskegee University experience challenges conventional wisdom: is integrative
      bioethics practice the new ethics for the public's health?
PG  - 15-33
LID - 10.1353/hpu.2012.0169 [doi]
AB  - The Tuskegee University National Center for Bioethics in Research and Health Care
      was established in 1999 in partial response to the Presidential Apology for the
      United States Public Health Service's Study of Untreated Syphilis in the Negro
      Male conducted in Macon County, Alabama, from 1932 to 1972. The Center's mission 
      of promoting equity and justice in health and health care for African Americans
      and other underserved populations employs an integrative bioethics approach
      informed by moral vision. Etymological and historical analyses are used to
      delineate the meaning and evolution of bioethics and to provide a basis for
      Tuskegee's integrative bioethics niche. Unlike mainstream bioethics, integrative 
      bioethics practice is holistic in orientation, and more robust for understanding 
      the epistemic realities of minority life, health disparities, and population
      health. The conclusion is that integrative bioethics is relevant to the survival 
      of all people, not just a privileged few; it could be the new ethics for the
      public's health.
FAU - Sodeke, Stephen Olufemi
AU  - Sodeke SO
AD  - Tuskegee University, National Center for Bioethics in Research and Health Care,
      Tuskegee, AL 36088, USA. sodeke@mytu.tuskegee.edu
LA  - eng
GR  - R13 MD006772/MD/NIMHD NIH HHS/United States
GR  - G12 MD007585/MD/NIMHD NIH HHS/United States
GR  - U54 CA118623/CA/NCI NIH HHS/United States
GR  - U54 CA118948/CA/NCI NIH HHS/United States
GR  - R13MD006772/MD/NIMHD NIH HHS/United States
GR  - U54CA118623/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Health Care Poor Underserved
JT  - Journal of health care for the poor and underserved
JID - 9103800
SB  - IM
MH  - African Americans
MH  - Alabama
MH  - *Bioethics
MH  - Humans
MH  - Male
MH  - Public Health/*ethics
MH  - Syphilis/ethnology
MH  - Universities/*organization & administration
PMC - PMC3726253
MID - NIHMS493878
EDAT- 2012/11/21 06:00
MHDA- 2013/02/13 06:00
CRDT- 2012/11/06 06:00
PHST- 2012/11/06 06:00 [entrez]
PHST- 2012/11/21 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
AID - S1548686912400444 [pii]
AID - 10.1353/hpu.2012.0169 [doi]
PST - ppublish
SO  - J Health Care Poor Underserved. 2012 Nov;23(4 Suppl):15-33. doi:
      10.1353/hpu.2012.0169.


PMID- 23162687
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121120
LR  - 20211021
IS  - 2042-5333 (Electronic)
IS  - 2042-5333 (Linking)
VI  - 3
IP  - 10
DP  - 2012 Oct
TI  - History and ethics of hand transplants.
PG  - 74
LID - 10.1258/shorts.2012.011178 [doi]
AB  - Hand transplantation is a form of composite tissue allotransplantation, whereby
      the hand of a cadaveric donor is transferred to the forearm of an amputee. The
      aim of such a procedure is to achieve better outcomes in terms of functionality
      and appearance when compared with prosthetics. The microsurgical techniques
      required have been well established for many years. In addition, advances in
      immunosuppressive therapy have meant that hand transplantation is a feasible
      therapeutic option. However this is not a life-saving procedure, requiring
      lifelong antirejection treatment with potentially serious side-effects. Hand
      transplantation is therefore a controversial concept with ethical, financial and 
      psychological implications that need careful consideration. Before this treatment
      can be fully accepted, further research is still required; this should be
      directed towards achieving immunological tolerance, while minimizing costs and
      potential side-effects of post-transplant therapy.
FAU - Errico, Michael
AU  - Errico M
AD  - Hull York Medical School , York, Hull HU6 7RX , UK.
FAU - Metcalfe, Neil H
AU  - Metcalfe NH
FAU - Platt, Alastair
AU  - Platt A
LA  - eng
PT  - Journal Article
DEP - 20121026
PL  - England
TA  - JRSM Short Rep
JT  - JRSM short reports
JID - 101536254
PMC - PMC3499956
EDAT- 2012/11/20 06:00
MHDA- 2012/11/20 06:01
CRDT- 2012/11/20 06:00
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2012/11/20 06:01 [medline]
AID - 10.1258/shorts.2012.011178 [doi]
AID - SHORTS-11-178 [pii]
PST - ppublish
SO  - JRSM Short Rep. 2012 Oct;3(10):74. doi: 10.1258/shorts.2012.011178. Epub 2012 Oct
      26.


PMID- 23162396
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121120
LR  - 20211021
IS  - 0975-3125 (Electronic)
VI  - 6
IP  - 3
DP  - 2012 Jul
TI  - Live donor hepatectomy for liver transplantation in Egypt: Lessons learned.
PG  - 234-41
LID - 10.4103/1658-354X.101214 [doi]
AB  - PURPOSE: To retrospectively review anesthesia and intensive care management of
      145 consented volunteers subjected to right lobe or left hepatectomy between 2003
      and 2011. METHODS: After local ethics committee approval, anesthetic and
      intensive care charts, blood transfusion requirements, laboratory data,
      complications and outcome of donors were analyzed. RESULTS: One hundred and
      forty-three volunteers successfully tolerated the surgery with no blood
      transfusion requirements, but with a morbidity rate of (50.1%). The most frequent
      complication was infection (21.1%) (intraabdominal collections), followed by
      biliary leak (18.2%). Two donors had major complications: one had portal vein
      thrombosis (PVT) treated with vascular stent. This patient recovered fully. The
      other donor had serious intraoperative bleeding and developed postoperative PVT
      and liver and renal failure. He died after 12 days despite intensive treatment.
      He was later reported among a series of fatalities from other centers worldwide. 
      Epidural analgesia was delivered safely (n=90) with no epidural hematoma despite 
      significantly elevated prothrombin time (PT) and international normalization
      ratio (INR) postoperatively, reaching the maximum on Day 1 (16.9+/-2.5 s and
      1.4+/-0.2, P<0.05 when compared with baseline). Hypophosphatemia and
      hypomagnesemia were frequently encountered. Total Mg and phosphorus blood levels 
      declined significantly to 1.05+/-0.18 mg/dL on Day 1 and 2.3+/-0.83 mg/dL on Day 
      3 postoperatively. CONCLUSIONS: Coagulation and electrolytes need to be monitored
      perioperatively and replaced adequately. PT and INR monitoring postoperatively is
      still necessary for best timing of epidural catheter removal. Live donor
      hepatectomy could be performed without blood transfusion. Bile leak and
      associated infection of abdominal collections requires further effort to better
      identify biliary leaks and modify the surgical closure of the bile ducts. Donor
      hepatectomy is definitely not a complication-free procedure; reported
      complication risks should be available to the volunteers during consenting.
FAU - Kamel, Emad
AU  - Kamel E
AD  - Department of Anaesthesia, National Liver Institute, Menoufiya University,
      Shebeen El-Kom, Menoufiya, Egypt.
FAU - Abdullah, Mohamed
AU  - Abdullah M
FAU - Hassanin, Ashraf
AU  - Hassanin A
FAU - Fayed, Nirmeen
AU  - Fayed N
FAU - Ahmed, Fatma
AU  - Ahmed F
FAU - Soliman, Hossam
AU  - Soliman H
FAU - Hegazi, Osama
AU  - Hegazi O
FAU - El Salam, Yasmine Abd
AU  - El Salam YA
FAU - Khalil, Magdy
AU  - Khalil M
FAU - Yassen, Khaled
AU  - Yassen K
FAU - Marwan, Ibrahim
AU  - Marwan I
FAU - Tanaka, Koichi
AU  - Tanaka K
FAU - Aboella, Khaled
AU  - Aboella K
FAU - Ibrahim, Tarek
AU  - Ibrahim T
LA  - eng
PT  - Journal Article
PL  - India
TA  - Saudi J Anaesth
JT  - Saudi journal of anaesthesia
JID - 101500601
PMC - PMC3498661
OTO - NOTNLM
OT  - Donor hepatectomy
OT  - Egypt
OT  - living donor liver transplantation
OT  - perioperative experience
EDAT- 2012/11/20 06:00
MHDA- 2012/11/20 06:01
CRDT- 2012/11/20 06:00
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2012/11/20 06:01 [medline]
AID - 10.4103/1658-354X.101214 [doi]
AID - SJA-6-234 [pii]
PST - ppublish
SO  - Saudi J Anaesth. 2012 Jul;6(3):234-41. doi: 10.4103/1658-354X.101214.


PMID- 23162392
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121120
LR  - 20211021
IS  - 0975-3125 (Electronic)
VI  - 6
IP  - 3
DP  - 2012 Jul
TI  - Hemodynamic changes during robotic radical prostatectomy.
PG  - 213-8
LID - 10.4103/1658-354X.101210 [doi]
AB  - BACKGROUND: Effect on hemodynamic changes and experience of robot-assisted
      laparoscopic radical prostatectomy (RALRP) in steep Trendelenburg position (45
      degrees ) with high-pressure CO(2) pneumoperitoneum is very limited. Therefore,
      we planned this prospective clinical trial to study the effect of steep
      Tredelenburg position with high-pressure CO(2) pneumoperitoneum on hemodynamic
      parameters in a patient undergoing RALRP using FloTrac/Vigileo1.10. METHODS:
      After ethical approval and informed consent, 15 patients scheduled for RALRP were
      included in the study. In the operation room, after attaching standard monitors, 
      the radial artery was cannulated. Anesthesia was induced with fentanyl (2 mug/kg)
      and thiopentone (4-7 mg/kg), and tracheal intubation was facilitated by
      vecuronium bromide (0.1 mg/kg). The patient's right internal jugular vein was
      cannulated and the Pre Sep central venous oximetry catheter was connected to it. 
      Anesthesia was maintained with isoflurane in oxygen and nitrous oxide and
      intermittent boluses of vecuronium. Intermittent positive-pressure ventilation
      was provided to maintain normocapnea. After CO(2) pneumoperitoneum, position of
      the patient was gradually changed to 45 degrees Trendelenburg over 5 min. The
      robot was then docked and the robot-assisted surgery started. Intraoperative
      monitoring included central venous pressure (CVP), stroke volume (SV), stroke
      volume variation (SVV), cardiac output (CO), cardiac index (CI) and central
      venous oxygen saturation (ScvO(2)). RESULTS: After induction of anesthesia, heart
      rate (HR), SV, CO and CI were decreased significantly from the baseline value
      (P>0.05). SV, CO and CI further decreased significantly after creating
      pneumoperitoneum (P>0.05). At the 45 degrees Trendelenburg position, HR, SV, CO
      and CI were significantly decreased compared with baseline. Thereafter, CO and CI
      were persistently low throughout the 45 degrees Trendelenburg position (P=0.001).
      HR at 20 min and 1 h, SV and mean arterial blood pressure after 2 h decreased
      significantly from the baseline value (P>0.05) during the 45 degrees
      Trendelenburg position. CVP increased significantly after creating
      pneumoperitoneum and at the 45 degrees Trendelenburg position (after 5 and 20
      min) compared with the baseline postinduction value (P>0.05). All these
      parameters returned to baseline after deflation of CO(2) pneumoperitoneum in the 
      supine position. There were no significant changes in SVV and ScvO(2) throughout 
      the study period. CONCLUSIONS: The steep Trendelenburg position and CO(2)
      pneumoperitoneum, during RALRP, leads to significant decrease in stroke volume
      and cardiac output.
FAU - Darlong, Vanlal
AU  - Darlong V
AD  - Department of Anaesthesiology and Intensive Care, All India Institute of Medical 
      Sciences, Ansari Nagar, New Delhi, India.
FAU - Kunhabdulla, Nishad Poolayullathil
AU  - Kunhabdulla NP
FAU - Pandey, Ravindra
AU  - Pandey R
FAU - Chandralekha
AU  - Chandralekha
FAU - Punj, Jyotsna
AU  - Punj J
FAU - Garg, Rakesh
AU  - Garg R
FAU - Kumar, Rajeev
AU  - Kumar R
LA  - eng
PT  - Journal Article
PL  - India
TA  - Saudi J Anaesth
JT  - Saudi journal of anaesthesia
JID - 101500601
PMC - PMC3498657
OTO - NOTNLM
OT  - Flotrac/vigileo
OT  - hemodynamic changes
OT  - pneumoperitoneum
OT  - steep trendelenburg position
EDAT- 2012/11/20 06:00
MHDA- 2012/11/20 06:01
CRDT- 2012/11/20 06:00
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2012/11/20 06:01 [medline]
AID - 10.4103/1658-354X.101210 [doi]
AID - SJA-6-213 [pii]
PST - ppublish
SO  - Saudi J Anaesth. 2012 Jul;6(3):213-8. doi: 10.4103/1658-354X.101210.


PMID- 23162390
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121120
LR  - 20211021
IS  - 0975-3125 (Electronic)
VI  - 6
IP  - 3
DP  - 2012 Jul
TI  - Comparison between intrathecal morphine with paravertebral patient controlled
      analgesia using bupivacaine for intraoperative and post-thoracotomy pain relief.
PG  - 201-6
LID - 10.4103/1658-354X.101204 [doi]
AB  - OBJECTIVES: This study was designed to compare the intrathecal morphine and
      paravertebral block with bupivacaine given before induction of anesthesia for
      intra-operative and post-thoracotomy pain relief for 48 hours using patient
      controlled paravertebral analgesia in post-operative period. METHODS: After taken
      an approval from the ethics committee of the University, 40 patients were
      randomly assigned to receive either preservative-free intrathecal morphine 0.3 mg
      in 3 ml normal saline together with paravertebral block (group I) or
      paravertebral block alone using bupivacaine (group II) before an induction of
      anesthesia. No continuous infusion of bupivacaine was started in both groups.
      Primary outcomes were Visual Analogue Score (VAS) at rest and on coughing.
      Hemodynamic and respiratory effects, bupivacaine consumption, patient's
      satisfaction, and side effects like nausea, vomiting, urinary retention, and
      itching were considered as secondary outcomes. All patients in both groups
      received paracetamol 1 gram (gm) IV every 6 hourly for the 1(st) 24 hr. Amount of
      rescue analgesic (pethidine 0.5 mg/kg IV) in both groups and total bupivacaine
      cumulative doses in 48 hrs were calculated. RESULTS: VAS at rest and on coughing 
      did not differ significantly between the 2 groups at 0, 1, 6, 12, 18, 24, and 48 
      hours (P= >0.1). At 24 hours, VAS increased in both the groups, but the increase 
      in VAS was comparable in both groups. There were insignificant incidences of
      nausea, purities, and urinary retention in intrathecal group compared with
      paravertebral group. The other side effects and patient satisfaction did not show
      any statistical significant difference between 2 groups. CONCLUSION: Intrathecal 
      morphine 0.3 mg is safe and effective way to improves pain control for thoracic
      surgery and was comparable to paravertebral patient control analgesia (PPCA) with
      bupivacaine for the 1(st) 48 hours post-thoracotomy.
FAU - Zeid, Haitham Abou
AU  - Zeid HA
AD  - Department of Anesthesiology, King Fahd Hospital of the University, University of
      Dammam, Dammam, Saudi Arabia.
FAU - Siddiqui, Ahsan Khaliq
AU  - Siddiqui AK
FAU - Elmakarem, Ehab F A
AU  - Elmakarem EF
FAU - Ghonaimy, Yasser
AU  - Ghonaimy Y
FAU - Al Nafea, Awatif
AU  - Al Nafea A
LA  - eng
PT  - Journal Article
PL  - India
TA  - Saudi J Anaesth
JT  - Saudi journal of anaesthesia
JID - 101500601
PMC - PMC3498655
OTO - NOTNLM
OT  - Bupivacaine
OT  - intrathecal morphine
OT  - paracetamol
OT  - paravertebral patient control analgesia
OT  - post-operative pain
OT  - thoracic surgery
EDAT- 2012/11/20 06:00
MHDA- 2012/11/20 06:01
CRDT- 2012/11/20 06:00
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2012/11/20 06:01 [medline]
AID - 10.4103/1658-354X.101204 [doi]
AID - SJA-6-201 [pii]
PST - ppublish
SO  - Saudi J Anaesth. 2012 Jul;6(3):201-6. doi: 10.4103/1658-354X.101204.


PMID- 23162201
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121120
LR  - 20211021
IS  - 0975-1564 (Electronic)
IS  - 0253-7176 (Linking)
VI  - 34
IP  - 2
DP  - 2012 Apr
TI  - Social dichotomy versus gender dichotomy: a case report of gender identity
      disorder.
PG  - 190-2
LID - 10.4103/0253-7176.101792 [doi]
AB  - Gender identity disorder is one of the most controversial diagnoses of DSM-IV and
      almost incomparable in the complexity of its social, ethical and political
      considerations to any other diagnosis. We present a case of 30 year-old male who 
      presented with complaints of suggestive of depressive disorder with a recent
      suicidal attempt. Careful history taking reveals underlying conflicts with
      prominent gender dysphoria and social complexities. The patient is managed
      primarily by pharmacotherapy and harm reduction model. Our case reflects a unique
      coping strategy against the present sociocultural values and ambiguity of law in 
      this part of the world.
FAU - Kumar, Kuldip
AU  - Kumar K
AD  - Department of Psychiatry, Vardhaman Mahavir Medical College and Safdarjang
      Hospital, New Delhi, India.
FAU - Gupta, Manushree
AU  - Gupta M
LA  - eng
PT  - Case Reports
PL  - United States
TA  - Indian J Psychol Med
JT  - Indian journal of psychological medicine
JID - 7910727
PMC - PMC3498788
OTO - NOTNLM
OT  - Gender identity
OT  - gender role
OT  - socio-cultural
EDAT- 2012/11/20 06:00
MHDA- 2012/11/20 06:01
CRDT- 2012/11/20 06:00
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2012/11/20 06:01 [medline]
AID - 10.4103/0253-7176.101792 [doi]
AID - IJPsyM-34-190 [pii]
PST - ppublish
SO  - Indian J Psychol Med. 2012 Apr;34(2):190-2. doi: 10.4103/0253-7176.101792.


PMID- 23162096
OWN - NLM
STAT- MEDLINE
DCOM- 20130307
LR  - 20220317
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 98
IP  - 1
DP  - 2013 Jan
TI  - Growth hormone receptor (GHR) exon 3 polymorphism status detection by
      dual-enzyme-linked immunosorbent assay (ELISA).
PG  - E77-81
LID - 10.1210/jc.2012-2375 [doi]
AB  - CONTEXT: GH receptor (GHR) exon 3-deleted/full-length (d3/fl) polymorphism has
      been proposed to affect the responsiveness to GH therapy. Conventional multiplex 
      PCR genotyping method for this polymorphism detection requires DNA samples, which
      may be difficult to obtain due to ethical and procedural issues and may limit
      further studies into the role of this polymorphism in health and disease.
      OBJECTIVE: The objective of the study was to develop a simple
      genotyping-alternative method for GHRd3 identification by directly measuring
      serum levels of total GH binding protein (tGHBP) and exon 3-positive
      GHBP[(E3(+)GHBP] by immunoassay and thereby assess the GHRd3 status. DESIGN: The 
      GHRd3 genotype was determined by PCR, and tGHBP and E3(+)GHBP levels were
      measured in serum of 88 healthy adults. MAIN OUTCOME MEASURES: The GHRd3
      chemotype by ELISA was compared with the genotype by conventional PCR. RESULTS:
      The concordance rate of GHR exon 3 status identification between PCR genotyping
      and ELISA chemotyping was shown to be 100%. There were negligible detectable
      serum levels of E3(+)GHBP in d3/d3 subjects. The ratio of serum levels E3(+)GHBP 
      vs. tGHBP in fl/fl and d3/fl subjects was (mean +/- SD) 96.6 +/- 5.1 and 57.1 +/-
      8.4%, respectively (P < 0.0001). Interestingly, we observed that d3/d3 subjects
      had significantly lower serum levels of tGHBP compared with fl/fl and d3/fl
      genotypes. CONCLUSIONS: This dual ELISA against tGHBP and E3(+)GHBP can be used
      as an alternative method for determining GHRd3 polymorphism status. The
      implications of differences in serum levels of tGHBP among different genotypes
      and responsiveness to GH therapy need to be further investigated.
FAU - Wan, JunXiang
AU  - Wan J
AD  - Department of Pediatrics, University of California, Los Angeles, Los Angeles,
      3715 McClintock Avenue, Los Angeles, California 90089-0191, USA.
FAU - Atzmon, Gil
AU  - Atzmon G
FAU - Hwang, David
AU  - Hwang D
FAU - Barzlai, Nir
AU  - Barzlai N
FAU - Kratzsch, Jurgen
AU  - Kratzsch J
FAU - Cohen, Pinchas
AU  - Cohen P
LA  - eng
GR  - P01AG027734/AG/NIA NIH HHS/United States
GR  - P01 AG034906/AG/NIA NIH HHS/United States
GR  - 2P30DK063491/DK/NIDDK NIH HHS/United States
GR  - P30 DK063491/DK/NIDDK NIH HHS/United States
GR  - P01 AG027734/AG/NIA NIH HHS/United States
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20121116
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Carrier Proteins)
RN  - 0 (Reagent Kits, Diagnostic)
RN  - 0 (Receptors, Somatotropin)
RN  - 0 (Recombinant Proteins)
RN  - 12629-01-5 (Human Growth Hormone)
RN  - W06KFL3RDT (somatotropin-binding protein)
SB  - IM
MH  - Adult
MH  - Carrier Proteins/blood/genetics
MH  - Case-Control Studies
MH  - DNA Mutational Analysis/*methods
MH  - Enzyme-Linked Immunosorbent Assay/methods
MH  - Exons/genetics
MH  - Genotype
MH  - Growth Disorders/diagnosis/genetics
MH  - Human Growth Hormone/analysis/metabolism
MH  - Humans
MH  - Longevity/genetics
MH  - *Polymorphism, Genetic/physiology
MH  - Reagent Kits, Diagnostic
MH  - Receptors, Somatotropin/blood/*genetics
MH  - Recombinant Proteins/analysis/metabolism
PMC - PMC3537082
EDAT- 2012/11/20 06:00
MHDA- 2013/03/08 06:00
CRDT- 2012/11/20 06:00
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2013/03/08 06:00 [medline]
AID - jc.2012-2375 [pii]
AID - 10.1210/jc.2012-2375 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2013 Jan;98(1):E77-81. doi: 10.1210/jc.2012-2375. Epub
      2012 Nov 16.


PMID- 23162071
OWN - NLM
STAT- MEDLINE
DCOM- 20130605
LR  - 20121221
IS  - 1552-6127 (Electronic)
IS  - 1090-1981 (Linking)
VI  - 39
IP  - 6
DP  - 2012 Dec
TI  - The CompHP core competencies framework for health promotion in Europe.
PG  - 648-62
LID - 10.1177/1090198112465620 [doi]
AB  - BACKGROUND: The CompHP Project on Developing Competencies and Professional
      Standards for Health Promotion in Europe was developed in response to the need
      for new and changing health promotion competencies to address health challenges. 
      This article presents the process of developing the CompHP Core Competencies
      Framework for Health Promotion across the European Union Member States and
      Candidate Countries. METHOD: A phased, multiple-method approach was employed to
      facilitate a consensus-building process on the development of the core
      competencies. Key stakeholders in European health promotion were engaged in a
      layered consultation process using the Delphi technique, online consultations,
      workshops, and focus groups. FINDINGS: Based on an extensive literature review, a
      mapping process was used to identify the core domains, which informed the first
      draft of the Framework. A consultation process involving two rounds of a Delphi
      survey with national experts in health promotion from 30 countries was carried
      out. In addition, feedback was received from 25 health promotion leaders who
      participated in two focus groups at a pan-European level and 116 health promotion
      practitioners who engaged in four country-specific consultations. A further 54
      respondents replied to online consultations, and there were a number of followers
      on various social media platforms. Based on four rounds of redrafting, the final 
      Framework document was produced, consisting of 11 core domains and 68 core
      competency statements. CONCLUSIONS: The CompHP Core Competencies Framework for
      Health Promotion provides a resource for workforce development in Europe, by
      articulating the necessary knowledge, skills, and abilities that are required for
      effective practice. The core domains are based on the multidisciplinary concepts,
      theories, and research that make health promotion distinctive. It is the combined
      application of all the domains, the knowledge base, and the ethical values that
      constitute the CompHP Core Competencies Framework for Health Promotion.
FAU - Barry, Margaret M
AU  - Barry MM
AD  - National University of Ireland Galway, Galway, Ireland.
      margaret.barry@nuigalway.ie
FAU - Battel-Kirk, Barbara
AU  - Battel-Kirk B
FAU - Dempsey, Colette
AU  - Dempsey C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121116
PL  - United States
TA  - Health Educ Behav
JT  - Health education & behavior : the official publication of the Society for Public 
      Health Education
JID - 9704962
SB  - IM
MH  - Communication
MH  - Consensus
MH  - Delphi Technique
MH  - Europe
MH  - Health Knowledge, Attitudes, Practice
MH  - Health Promotion/*organization & administration/standards
MH  - Humans
MH  - Leadership
MH  - Needs Assessment
MH  - *Professional Competence
EDAT- 2012/11/20 06:00
MHDA- 2013/06/06 06:00
CRDT- 2012/11/20 06:00
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2013/06/06 06:00 [medline]
AID - 1090198112465620 [pii]
AID - 10.1177/1090198112465620 [doi]
PST - ppublish
SO  - Health Educ Behav. 2012 Dec;39(6):648-62. doi: 10.1177/1090198112465620. Epub
      2012 Nov 16.


PMID- 23161839
OWN - NLM
STAT- MEDLINE
DCOM- 20130319
LR  - 20121119
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 19
IP  - 6
DP  - 2012 Nov
TI  - Slow ethics for nursing practice.
PG  - 711-3
LID - 10.1177/0969733012461839 [doi]
FAU - Gallagher, Ann
AU  - Gallagher A
LA  - eng
PT  - Editorial
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Humans
MH  - Nursing Care/*ethics
MH  - Time Factors
EDAT- 2012/11/20 06:00
MHDA- 2013/03/21 06:00
CRDT- 2012/11/20 06:00
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2013/03/21 06:00 [medline]
AID - 19/6/711 [pii]
AID - 10.1177/0969733012461839 [doi]
PST - ppublish
SO  - Nurs Ethics. 2012 Nov;19(6):711-3. doi: 10.1177/0969733012461839.


PMID- 23161617
OWN - NLM
STAT- MEDLINE
DCOM- 20150331
LR  - 20131118
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 12
DP  - 2013 Dec
TI  - Phase 1 oncology trials and informed consent.
PG  - 761-4
LID - 10.1136/medethics-2012-100832 [doi]
AB  - Ethical concerns have been raised about the quality of informed consent by
      participants in phase 1 oncology trials. Interview surveys indicate that
      substantial proportions of trial participants do not understand the purpose of
      these trials-evaluating toxicity and dosing for subsequent efficacy studies-and
      overestimate the prospect of therapeutic benefit that they offer. In this article
      we argue that although these data suggest the desirability of enhancing the
      process of information disclosure and assessment of comprehension of the
      implications of study participation, they do not necessarily invalidate consent
      by phase 1 trial participants.
FAU - Miller, Franklin G
AU  - Miller FG
AD  - Department of Bioethics, National Institutes of Health, , Bethesda, Maryland,
      USA.
FAU - Joffe, Steven
AU  - Joffe S
LA  - eng
PT  - Journal Article
DEP - 20121117
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Bioethics
MH  - Clinical Trials, Phase I as Topic/*ethics
MH  - Comprehension
MH  - Decision Making
MH  - Disclosure
MH  - Ethics, Medical
MH  - *Ethics, Research
MH  - Humans
MH  - Informed Consent/ethics/*standards
MH  - Nontherapeutic Human Experimentation/*ethics
MH  - Research Subjects/*psychology
OTO - NOTNLM
OT  - Informed Consent
EDAT- 2012/11/20 06:00
MHDA- 2015/04/01 06:00
CRDT- 2012/11/20 06:00
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2015/04/01 06:00 [medline]
AID - medethics-2012-100832 [pii]
AID - 10.1136/medethics-2012-100832 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Dec;39(12):761-4. doi: 10.1136/medethics-2012-100832. Epub
      2012 Nov 17.


PMID- 23161614
OWN - NLM
STAT- MEDLINE
DCOM- 20141112
LR  - 20181202
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 10
DP  - 2013 Oct
TI  - Recruiting medics from the poorest nations? It could be worse....
PG  - 610-1; discussion 618-20
LID - 10.1136/medethics-2012-101134 [doi]
FAU - Brassington, Iain
AU  - Brassington I
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20121117
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
CON - J Med Ethics. 2013 Oct;39(10):603-9. PMID: 23112042
MH  - Emigration and Immigration/*trends
MH  - *Health Personnel
MH  - Health Services Needs and Demand/*ethics
MH  - Humans
MH  - Personnel Selection/*ethics
OTO - NOTNLM
OT  - Health Personnel
OT  - International Migration of Health Professionals
OT  - Public Health Ethics
EDAT- 2012/11/20 06:00
MHDA- 2014/11/13 06:00
CRDT- 2012/11/20 06:00
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2014/11/13 06:00 [medline]
AID - medethics-2012-101134 [pii]
AID - 10.1136/medethics-2012-101134 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Oct;39(10):610-1; discussion 618-20. doi:
      10.1136/medethics-2012-101134. Epub 2012 Nov 17.


PMID- 23161613
OWN - NLM
STAT- MEDLINE
DCOM- 20160926
LR  - 20161126
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 42
IP  - 2
DP  - 2016 Feb
TI  - Learning the law: practical proposals for UK medical education.
PG  - 138-40
LID - 10.1136/medethics-2012-101013 [doi]
AB  - Ongoing serious breaches in medical professionalism might be avoided if UK
      doctors rethink their approach to law. UK medical education has a role in
      creating a climate of change by re-examining how law is taught to medical
      students. Adopting a more insightful approach in the UK to the impact of The
      Human Rights Act and learning to manipulate legal concepts, such as conflict of
      interest, need to be taught to medical students now if UK doctors are to manage
      complex decision-making in the NHS of the future. The literature is reviewed from
      a unique personal perspective of a doctor and lawyer, and practical proposals for
      developing medical education in law in the UK are suggested.
CI  - Published by the BMJ Publishing Group Limited. For permission to use (where not
      already granted under a licence) please go to
      http://www.bmj.com/company/products-services/rights-and-licensing/
FAU - Margetts, J K
AU  - Margetts JK
AD  - Centre for Medical Education Research, Durham University, Durham, UK.
LA  - eng
PT  - Journal Article
DEP - 20121117
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Clinical Medicine/*education/legislation & jurisprudence
MH  - Curriculum/*standards
MH  - Decision Making
MH  - Education, Medical, Undergraduate/*standards
MH  - Ethics, Medical/*education
MH  - Humans
MH  - Jurisprudence
MH  - *Students, Medical
MH  - United Kingdom
OTO - NOTNLM
OT  - Clinical Ethics
OT  - Education
OT  - Law
OT  - Legal Aspects
OT  - Professional Misconduct
EDAT- 2012/11/20 06:00
MHDA- 2016/09/27 06:00
CRDT- 2012/11/20 06:00
PHST- 2012/08/12 00:00 [received]
PHST- 2012/09/21 00:00 [accepted]
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2016/09/27 06:00 [medline]
AID - medethics-2012-101013 [pii]
AID - 10.1136/medethics-2012-101013 [doi]
PST - ppublish
SO  - J Med Ethics. 2016 Feb;42(2):138-40. doi: 10.1136/medethics-2012-101013. Epub
      2012 Nov 17.


PMID- 23161591
OWN - NLM
STAT- MEDLINE
DCOM- 20140714
LR  - 20131023
IS  - 1097-0347 (Electronic)
IS  - 1043-3074 (Linking)
VI  - 35
IP  - 11
DP  - 2013 Nov
TI  - Clinical ethics consultation in patients with head and neck cancer.
PG  - 1647-51
LID - 10.1002/hed.23204 [doi]
AB  - BACKGROUND: The purpose of this study was to describe the impact of clinical
      ethics consultations among patients with head and neck cancer in order to better 
      anticipate and manage clinical challenges. METHODS: A database was queried to
      identify patients with head and neck cancer for whom ethics consultation was
      performed at a comprehensive cancer center (n = 14). Information from the
      database was verified via data abstraction and analyzed qualitatively and
      quantitatively. RESULTS: Common requests for ethics consultation involved code
      status (6 of 14) and withdrawal/withholding life-sustaining treatments (6 of 14).
      Common contextual features were interpersonal conflicts (6 of 14) and
      communication barriers (5 of 14). Airway management concerns were frequent (5 of 
      14). Whereas 21% of patients had do not resuscitate (DNR) orders before ethics
      consultation, 79% were DNR subsequently. CONCLUSION: Ethics consultations among
      patients with head and neck cancer reflect distinctive complexities inherent to
      their disease, but are entirely consistent with global clinical ethical themes.
      Consideration of communication barriers, social isolation/stigma, symptom
      control, and airway management are critical.
CI  - Copyright (c) 2012 Wiley Periodicals, Inc.
FAU - Shuman, Andrew G
AU  - Shuman AG
AD  - Head and Neck Surgery Service, Memorial Sloan-Kettering Cancer Center, New York, 
      New York; Ethics Committee, Memorial Sloan-Kettering Cancer Center, New York, New
      York; Division of Medical Ethics, Weill Cornell Medical College, New York, New
      York.
FAU - McCabe, Mary S
AU  - McCabe MS
FAU - Fins, Joseph J
AU  - Fins JJ
FAU - Kraus, Dennis H
AU  - Kraus DH
FAU - Shah, Jatin P
AU  - Shah JP
FAU - Patel, Snehal G
AU  - Patel SG
LA  - eng
PT  - Journal Article
DEP - 20121117
PL  - United States
TA  - Head Neck
JT  - Head & neck
JID - 8902541
SB  - IM
MH  - Adult
MH  - Advance Directives/*ethics
MH  - Aged
MH  - Aged, 80 and over
MH  - Cancer Care Facilities
MH  - Cohort Studies
MH  - Databases, Factual
MH  - Ethics Consultation/*organization & administration
MH  - *Ethics, Clinical
MH  - Female
MH  - Head and Neck Neoplasms/*mortality/pathology/*therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Palliative Care/ethics/methods
MH  - Quality of Health Care
MH  - Retrospective Studies
MH  - Terminal Care/*ethics
MH  - Terminally Ill
MH  - Young Adult
OTO - NOTNLM
OT  - clinical ethics
OT  - end of life care
OT  - ethics consultation
OT  - head and neck cancer
OT  - palliative care
EDAT- 2012/11/20 06:00
MHDA- 2014/07/16 06:00
CRDT- 2012/11/20 06:00
PHST- 2012/09/19 00:00 [accepted]
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2014/07/16 06:00 [medline]
AID - 10.1002/hed.23204 [doi]
PST - ppublish
SO  - Head Neck. 2013 Nov;35(11):1647-51. doi: 10.1002/hed.23204. Epub 2012 Nov 17.


PMID- 23161092
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121120
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 6
DP  - 2012
TI  - Promoting physical activity in sedentary elderly Malays with type 2 diabetes: a
      protocol for randomised controlled trial.
LID - 10.1136/bmjopen-2012-002119 [doi]
LID - e002119 [pii]
AB  - INTRODUCTION: Like many countries Malaysia is facing an increase in the number of
      people with type 2 diabetes mellitus diabetes (T2DM) and modifiable lifestyle
      factors such as sedentary behaviour are important drivers of this increase. The
      level of physical activity is low among elderly Malay people. In Malaysia,
      strategies to promote physical activity in elderly Malay people with T2DM are not
      well documented in the research literature. This paper discusses an intervention 
      to increase physical activity in elderly Malay people with T2DM. The aim of our
      study was to evaluate the effectiveness of personalised feedback alone and in
      combination with peer support in promoting and maintaining physical activity in
      comparison with usual care. METHODS AND ANALYSIS: A three-arm randomised
      controlled trial will be conducted among sedentary Malay adults aged 60 years and
      above with T2DM attending an urban primary healthcare clinic in Malaysia. The
      participants will be randomised into three groups for a 12-week intervention with
      a follow-up at 24 and 36 weeks to assess adherence. The primary outcome of this
      study is pedometer-determined physical activity. Glycaemic and blood pressure
      control, body composition, cardiorespiratory fitness, balance, lipid profile,
      health-related quality of life, psychological well-being, social support and
      self-efficacy for exercise are the secondary measures. Linear mixed models will
      be used to determine the effect of the intervention over time and between groups.
      ETHICAL AND DISSEMINATION: The Monash University Human Research Ethics Committee 
      and the Malaysian Ministry of Health's Medical Research Ethics Committee approved
      this protocol. The findings of this study will be presented at international
      conferences and published in peer-reviewed journals. TRIAL REGISTRATION: This
      study protocol has been registered with the Malaysian National Medical Research
      Registry and with the Current Controlled Trial Ltd
      (http://www.controlled-trials.com/ISRCTN71447000/).
FAU - Sazlina, Shariff-Ghazali
AU  - Sazlina SG
AD  - Department of Family Medicine, Universiti Putra, Malaysia, Serdang, Selangor,
      Malaysia.
FAU - Browning, Colette Joy
AU  - Browning CJ
FAU - Yasin, Shajahan
AU  - Yasin S
LA  - eng
PT  - Journal Article
DEP - 20121115
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3533096
EDAT- 2012/11/20 06:00
MHDA- 2012/11/20 06:01
CRDT- 2012/11/20 06:00
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2012/11/20 06:01 [medline]
AID - bmjopen-2012-002119 [pii]
AID - 10.1136/bmjopen-2012-002119 [doi]
PST - epublish
SO  - BMJ Open. 2012 Nov 15;2(6). pii: bmjopen-2012-002119. doi:
      10.1136/bmjopen-2012-002119. Print 2012.


PMID- 23160584
OWN - NLM
STAT- MEDLINE
DCOM- 20130201
LR  - 20121119
IS  - 0807-7096 (Electronic)
IS  - 0029-2001 (Linking)
VI  - 132
IP  - 21
DP  - 2012 Nov 12
TI  - [Which projects should be submitted to the regional ethics committee?].
PG  - 2366-7
LID - 10.4045/tidsskr.12.1082 [doi]
FAU - Lekven, Jon
AU  - Lekven J
AD  - REK Vest, Norway. jon.lekven@kir.uib.no
FAU - Gisvold, Sven Erik
AU  - Gisvold SE
FAU - Hardang, Jorgen
AU  - Hardang J
LA  - nor
PT  - Journal Article
TT  - Hvilke prosjekter skal legges frem for regional etisk komite?
PL  - Norway
TA  - Tidsskr Nor Laegeforen
JT  - Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny
      raekke
JID - 0413423
SB  - IM
MH  - *Ethics Committees, Research
MH  - Ethics, Research
MH  - Humans
MH  - Legislation, Medical
MH  - Norway
MH  - Quality Assurance, Health Care/*ethics/standards
EDAT- 2012/11/20 06:00
MHDA- 2013/02/05 06:00
CRDT- 2012/11/20 06:00
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2013/02/05 06:00 [medline]
AID - 2926676 [pii]
AID - 10.4045/tidsskr.12.1082 [doi]
PST - ppublish
SO  - Tidsskr Nor Laegeforen. 2012 Nov 12;132(21):2366-7. doi: 10.4045/tidsskr.12.1082.


PMID- 23160575
OWN - NLM
STAT- MEDLINE
DCOM- 20130201
LR  - 20181202
IS  - 0807-7096 (Electronic)
IS  - 0029-2001 (Linking)
VI  - 132
IP  - 21
DP  - 2012 Nov 12
TI  - [What should be presented to the regional ethics committee?].
PG  - 2359-60; author reply 2360
LID - 10.4045/tidsskr.12.1229 [doi]
FAU - Bruusgaard, Dag
AU  - Bruusgaard D
LA  - nor
PT  - Letter
PT  - Comment
TT  - Hva skal fremlegges for regional etisk komite?
PL  - Norway
TA  - Tidsskr Nor Laegeforen
JT  - Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny
      raekke
JID - 0413423
SB  - IM
CON - Tidsskr Nor Laegeforen. 2012 Jun 26;132(12-13):1433. PMID: 22766813
MH  - Biomedical Research/*ethics
MH  - *Ethics, Research
MH  - Humans
MH  - *Research Design
EDAT- 2012/11/20 06:00
MHDA- 2013/02/05 06:00
CRDT- 2012/11/20 06:00
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2013/02/05 06:00 [medline]
AID - 2926376 [pii]
AID - 10.4045/tidsskr.12.1229 [doi]
PST - ppublish
SO  - Tidsskr Nor Laegeforen. 2012 Nov 12;132(21):2359-60; author reply 2360. doi:
      10.4045/tidsskr.12.1229.


PMID- 23160252
OWN - NLM
STAT- MEDLINE
DCOM- 20130516
LR  - 20121119
IS  - 1538-1145 (Electronic)
IS  - 1527-4160 (Linking)
VI  - 18
IP  - 6
DP  - 2012 Nov
TI  - Avatar therapy: where technology, symbols, culture, and connection collide.
PG  - 451-9
LID - 10.1097/01.pra.0000422745.17990.be [doi]
AB  - The topic of "e-therapy" is of great research and clinical interest in 2012. This
      article presents a case study that examines several elements of psychotherapy, as
      administered in the "Second Life" virtual environment. In this case,
      psychotherapy took place primarily via text messaging between two avatars (client
      and therapist) who "sat" in a virtual office. The therapist resided in the United
      States and provided therapy to an individual from a developing nation who was
      currently residing in another more developed Middle Eastern country for work and 
      to escape political atrocities being committed in his home country. This case
      example raises many issues that could be explored, including the ethics of
      providing such therapy, cultural competence, technological details, and providing
      therapy across national lines. However, due to the complicated and multifaceted
      nature of providing therapy in a virtual environment, this case presentation
      focuses on technical issues, such as the basics of providing therapy in Second
      Life. Given that the patient in this case used multiple avatars (cartoon-like
      representations of himself) in therapy, the topic of the avatar as the expression
      of internal representations and conflicts is also examined. This case report also
      discusses the patient's presenting problems and elements of the therapeutic
      alliance such as transference and countertransference. Finally, suggestions for
      future research are made. The author posits that mental health professionals can 
      now reach at-risk patients (e.g., refugees residing in other countries) whom they
      were not previously able to treat and suggests that mental health practitioners
      may have an ethical duty to research and provide these kinds of services so that 
      certain underserved populations may be treated. (Journal of Psychiatric Practice 
      2012;18:451-459).
FAU - Quackenbush, Debra M
AU  - Quackenbush DM
AD  - The Menninger Clinic and Baylor College of Medicine, Houston, USA.
FAU - Krasner, Aaron
AU  - Krasner A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Psychiatr Pract
JT  - Journal of psychiatric practice
JID - 100901141
SB  - IM
MH  - Adult
MH  - Culture
MH  - Humans
MH  - Male
MH  - Mental Disorders/*therapy
MH  - *Metaphor
MH  - *Psychotherapy/instrumentation/methods
MH  - Telemedicine/instrumentation/methods
MH  - *User-Computer Interface
EDAT- 2012/11/20 06:00
MHDA- 2013/05/17 06:00
CRDT- 2012/11/20 06:00
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2013/05/17 06:00 [medline]
AID - 10.1097/01.pra.0000422745.17990.be [doi]
AID - 00131746-201211000-00010 [pii]
PST - ppublish
SO  - J Psychiatr Pract. 2012 Nov;18(6):451-9. doi: 10.1097/01.pra.0000422745.17990.be.


PMID- 23160160
OWN - NLM
STAT- MEDLINE
DCOM- 20130305
LR  - 20220325
IS  - 1530-6550 (Print)
IS  - 1530-6550 (Linking)
VI  - 13
IP  - 2-3
DP  - 2012
TI  - California ACC goals.
PG  - e121-3
LID - 10.3909/ricm0662 [doi]
AB  - MISSION: To advocate for accessible, highest quality, cost-effective
      cardiovascular care for Californians. The purpose of the Chapter shall be to
      contribute to the prevention of cardiovascular diseases, to ensure optimal
      quality care for the individuals with such diseases, and to foster the highest
      professional ethical standards.
FAU - Bommer, William J
AU  - Bommer WJ
AD  - University of California, Davis, CA, USA.
LA  - eng
PT  - Journal Article
PL  - Singapore
TA  - Rev Cardiovasc Med
JT  - Reviews in cardiovascular medicine
JID - 100960007
SB  - IM
MH  - California
MH  - Cardiology/*organization & administration
MH  - *Cardiovascular Diseases/diagnosis/prevention & control/therapy
MH  - Cooperative Behavior
MH  - Humans
MH  - International Cooperation
MH  - Organizational Objectives
MH  - Preventive Health Services/organization & administration
MH  - Program Development
MH  - Societies, Medical/*organization & administration
EDAT- 2012/11/20 06:00
MHDA- 2013/03/06 06:00
CRDT- 2012/11/20 06:00
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2013/03/06 06:00 [medline]
AID - 10.3909/ricm0662 [doi]
PST - ppublish
SO  - Rev Cardiovasc Med. 2012;13(2-3):e121-3. doi: 10.3909/ricm0662.


PMID- 23160103
OWN - NLM
STAT- MEDLINE
DCOM- 20130419
LR  - 20211021
IS  - 1438-8871 (Electronic)
IS  - 1438-8871 (Linking)
VI  - 14
IP  - 6
DP  - 2012 Nov 16
TI  - How should debriefing be undertaken in web-based studies? Findings from a
      randomized controlled trial.
PG  - e157
LID - 10.2196/jmir.2186 [doi]
AB  - BACKGROUND: Internet research may raise older ethical issues in new forms or pose
      new issues. It has been recommended that debriefing information online be kept
      very short, with further information including study results made available if
      requested by participants. There are no empirical studies that compare possible
      alternative methods of debriefing in online studies. OBJECTIVE: To undertake a
      randomized controlled trial evaluating how to implement the recommended approach 
      by assessing the effects of two different approaches on accessing of additional
      information. METHODS: All 11,943 participants in the Effects of Study Design and 
      Allocation (ESDA) study, which employed deception, were randomly assigned to one 
      of two methods of debriefing: Group A received the debriefing information in the 
      body of an email with links to protocol and results pages; Group B was presented 
      with these links after clicking on an initial link in the body of the email to
      view the debriefing information on a website. Outcomes assessed were the
      proportions clicking on the links to the protocol and results summary and the
      time spent on these pages by those accessing them. RESULTS: The group who were
      presented with no debriefing information in the body of the email and went to a
      website for this information (Group B) were approximately twice as likely to
      subsequently access the protocol and the results summary. These differences
      between the two groups were highly statistically significant. Although these
      differences are clear, the overall proportions accessing such information were
      low, and there were no differences in mean time spent reading these pages. Only
      one quarter of Group B actually accessed debriefing information. CONCLUSIONS: In 
      circumstances where the uptake of fuller information on study design, methods,
      and findings is deemed important, debriefing information may be better provided
      via a link and not included in the body of an email. Doing so may, however,
      reduce the extent of receiving any debriefing information at all. There is a
      wider need for high quality empirical studies to inform ethical evaluations.
      TRIAL REGISTRATION: Australian New Zealand Clinical Trials Registry,
      ACTRN12610000846022 (http://www.anzctr.org.au/).
FAU - McCambridge, Jim
AU  - McCambridge J
AD  - Department of Social & Environmental Health Research, LSHTM, London, London,
      United Kingdom. Jim.McCambridge@lshtm.ac.uk
FAU - Kypri, Kypros
AU  - Kypri K
FAU - Wilson, Amanda
AU  - Wilson A
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20121116
PL  - Canada
TA  - J Med Internet Res
JT  - Journal of medical Internet research
JID - 100959882
SB  - IM
MH  - Electronic Mail
MH  - *Ethics
MH  - *Internet
MH  - *Research Design
PMC - PMC3510731
EDAT- 2012/11/20 06:00
MHDA- 2013/04/23 06:00
CRDT- 2012/11/20 06:00
PHST- 2012/05/26 00:00 [received]
PHST- 2012/07/30 00:00 [accepted]
PHST- 2012/07/18 00:00 [revised]
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2013/04/23 06:00 [medline]
AID - v14i6e157 [pii]
AID - 10.2196/jmir.2186 [doi]
PST - epublish
SO  - J Med Internet Res. 2012 Nov 16;14(6):e157. doi: 10.2196/jmir.2186.


PMID- 23160037
OWN - NLM
STAT- MEDLINE
DCOM- 20140124
LR  - 20151119
IS  - 1879-176X (Electronic)
IS  - 0300-5712 (Linking)
VI  - 41
IP  - 2
DP  - 2013 Feb
TI  - A 3-day randomised clinical study investigating the efficacy of two toothpastes, 
      designed to occlude dentine tubules, for the treatment of dentine
      hypersensitivity.
PG  - 187-94
LID - 10.1016/j.jdent.2012.11.007 [doi]
LID - S0300-5712(12)00309-0 [pii]
AB  - OBJECTIVES: A product comparison study to compare the short term clinical
      efficacy of a strontium acetate/silica toothpaste with an arginine/calcium
      carbonate paste for pain reduction in dentine hypersensitivity. METHODS: The
      study was examiner blind of two arm parallel design. Eighty healthy adult
      subjects from general dental practice with >/=2 sensitive teeth but otherwise
      good oral health, were enrolled and randomised to 1 of 2 toothpaste treatments,
      schedule provided by the sponsor. Almost equal numbers received each treatment.
      Tooth sensitivity was measured in three ways; evaporative (Schiff score; Visual
      Analogue Scale) and tactile stimuli (Yeaple probe), prior to and immediately
      after subjects' self application of a single pea sized dose of toothpaste, and
      following subsequent twice daily brushing for three days with the paste. RESULTS:
      All 80 subjects completed the study. Results confirm that for both treatments,
      pain was reduced immediately and relief was sustained after 3 days use. For all 3
      measures, benefit was similar between the two pastes, with no statistical or
      clinical difference demonstrated, apart from response to evaporative stimulus at 
      3 days, where Schiff scores were significantly lower in the arginine group,
      p=0.02. CONCLUSIONS: It can be concluded that both desensitising, occluding
      toothpastes provided reduction of pain from dentine hypersensitivity on a short
      term basis: toothpastes appearing to be clinically similarly effective both after
      a single subject dab on application and post twice daily brushing for three days.
      National Research Ethics Service register number 09/H020/57.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - West, N
AU  - West N
AD  - Applied Clinical Research Group, Department of Oral and Dental Science University
      of Bristol, UK. N.X.West@bristol.ac.uk
FAU - Newcombe, R G
AU  - Newcombe RG
FAU - Hughes, N
AU  - Hughes N
FAU - Mason, S
AU  - Mason S
FAU - Maggio, B
AU  - Maggio B
FAU - Sufi, F
AU  - Sufi F
FAU - Claydon, N
AU  - Claydon N
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20121114
PL  - England
TA  - J Dent
JT  - Journal of dentistry
JID - 0354422
RN  - 0 (Acetates)
RN  - 0 (Cariostatic Agents)
RN  - 0 (Dentin Desensitizing Agents)
RN  - 0 (Phosphates)
RN  - 0 (Toothpastes)
RN  - 15181-43-8 (fluorophosphate)
RN  - 4SL32YMY7B (strontium acetate)
RN  - 7631-86-9 (Silicon Dioxide)
RN  - 8ZYQ1474W7 (Sodium Fluoride)
RN  - 94ZLA3W45F (Arginine)
RN  - H0G9379FGK (Calcium Carbonate)
RN  - Q80VPU408O (Fluorides)
RN  - YZS2RPE8LE (Strontium)
SB  - IM
MH  - Acetates/therapeutic use
MH  - Adult
MH  - Arginine/therapeutic use
MH  - Calcium Carbonate/therapeutic use
MH  - Cariostatic Agents/therapeutic use
MH  - Cold Temperature
MH  - Dentin/*drug effects/ultrastructure
MH  - Dentin Desensitizing Agents/*therapeutic use
MH  - Dentin Sensitivity/*drug therapy/prevention & control
MH  - Desiccation
MH  - Female
MH  - Fluorides/therapeutic use
MH  - Humans
MH  - Male
MH  - Pain Measurement
MH  - Pain Threshold/drug effects
MH  - Phosphates/therapeutic use
MH  - Physical Stimulation
MH  - Silicon Dioxide/therapeutic use
MH  - Single-Blind Method
MH  - Sodium Fluoride/therapeutic use
MH  - Strontium/therapeutic use
MH  - Toothpastes/*therapeutic use
MH  - Touch/physiology
MH  - Treatment Outcome
EDAT- 2012/11/20 06:00
MHDA- 2014/01/25 06:00
CRDT- 2012/11/20 06:00
PHST- 2012/04/20 00:00 [received]
PHST- 2012/10/22 00:00 [revised]
PHST- 2012/11/06 00:00 [accepted]
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2014/01/25 06:00 [medline]
AID - S0300-5712(12)00309-0 [pii]
AID - 10.1016/j.jdent.2012.11.007 [doi]
PST - ppublish
SO  - J Dent. 2013 Feb;41(2):187-94. doi: 10.1016/j.jdent.2012.11.007. Epub 2012 Nov
      14.


PMID- 23159999
OWN - NLM
STAT- MEDLINE
DCOM- 20140414
LR  - 20130821
IS  - 1524-8399 (Print)
IS  - 1524-8399 (Linking)
VI  - 14
IP  - 5
DP  - 2013 Sep
TI  - Using photovoice as a participatory evaluation tool in Kaiser Permanente's
      Community Health Initiative.
PG  - 686-94
LID - 10.1177/1524839912463232 [doi]
AB  - Photovoice is a community-based participatory research method that provides
      participants who traditionally have little voice in community policy decisions,
      with training in photography, ethics, critical dialogue, photo captioning, and
      policy advocacy. Photovoice has been used primarily as a needs assessment and
      advocacy tool and only rarely as a pre-/postintervention evaluation method. This 
      article describes the use of Photovoice as a participatory evaluation method in
      the Community Health Initiative, a 6-year, multisite community-based obesity
      prevention initiative, sponsored by Kaiser Permanente. Fifty community
      participants (including six youth) from six Community Health Initiative
      communities used photos and captions to identify, from their perspective, the
      most significant accomplishments from the initiative at both baseline and
      follow-up. Accomplishments identified included increased access to fresh/healthy 
      food in local neighborhoods; policy changes supporting a "healthy eating, active 
      living" community; increased access to physical activity; changes to the built
      environment creating increased neighborhood walkability/safety; and leadership
      development.
FAU - Kramer, Leila
AU  - Kramer L
AD  - Center for Community Health and Evaluation, Seattle, WA, USA.
FAU - Schwartz, Pamela
AU  - Schwartz P
FAU - Cheadle, Allen
AU  - Cheadle A
FAU - Rauzon, Suzanne
AU  - Rauzon S
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20121116
PL  - United States
TA  - Health Promot Pract
JT  - Health promotion practice
JID - 100890609
SB  - IM
MH  - Community-Based Participatory Research/*methods
MH  - Diet
MH  - Environment
MH  - Exercise
MH  - Health Policy
MH  - Health Promotion/*methods
MH  - Humans
MH  - Obesity/prevention & control
MH  - *Photography
MH  - Program Evaluation/*methods
MH  - Socioeconomic Factors
OTO - NOTNLM
OT  - Photovoice
OT  - environmental change
OT  - obesity prevention
OT  - participatory evaluation
OT  - photo documentation
OT  - policy change
EDAT- 2012/11/20 06:00
MHDA- 2014/04/15 06:00
CRDT- 2012/11/20 06:00
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2014/04/15 06:00 [medline]
AID - 1524839912463232 [pii]
AID - 10.1177/1524839912463232 [doi]
PST - ppublish
SO  - Health Promot Pract. 2013 Sep;14(5):686-94. doi: 10.1177/1524839912463232. Epub
      2012 Nov 16.


PMID- 23159523
OWN - NLM
STAT- MEDLINE
DCOM- 20130919
LR  - 20171116
IS  - 1879-1611 (Electronic)
IS  - 0022-1910 (Linking)
VI  - 59
IP  - 2
DP  - 2013 Feb
TI  - Integrating nutrition and immunology: a new frontier.
PG  - 130-7
LID - 10.1016/j.jinsphys.2012.10.011 [doi]
LID - S0022-1910(12)00254-5 [pii]
AB  - Nutrition is critical to immune defence and parasite resistance, which not only
      affects individual organisms, but also has profound ecological and evolutionary
      consequences. Nutrition and immunity are complex traits that interact via
      multiple direct and indirect pathways, including the direct effects of nutrition 
      on host immunity but also indirect effects mediated by the host's microbiota and 
      pathogen populations. The challenge remains, however, to capture the complexity
      of the network of interactions that defines nutritional immunology. The aim of
      this paper is to discuss the recent findings in nutritional research in the
      context of immunological studies. By taking examples from the entomological
      literature, we argue that insects provide a powerful tool for examining the
      network of interactions between nutrition and immunity due to their tractability,
      short lifespan and ethical considerations. We describe the relationships between 
      dietary composition, immunity, disease and microbiota in insects, and highlight
      the importance of adopting an integrative and multi-dimensional approach to
      nutritional immunology.
CI  - Crown Copyright (c) 2012. Published by Elsevier Ltd. All rights reserved.
FAU - Ponton, Fleur
AU  - Ponton F
AD  - School of Biological Sciences, The University of Sydney, Sydney, New South Wales 
      2006, Australia. fleur_ponton@hotmail.com
FAU - Wilson, Kenneth
AU  - Wilson K
FAU - Holmes, Andrew J
AU  - Holmes AJ
FAU - Cotter, Sheena C
AU  - Cotter SC
FAU - Raubenheimer, David
AU  - Raubenheimer D
FAU - Simpson, Stephen J
AU  - Simpson SJ
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121115
PL  - England
TA  - J Insect Physiol
JT  - Journal of insect physiology
JID - 2985080R
SB  - IM
MH  - Animal Nutritional Physiological Phenomena
MH  - Animals
MH  - Diet
MH  - Gastrointestinal Tract/microbiology/parasitology/physiology
MH  - *Immunity, Innate
MH  - Insecta/immunology/microbiology/parasitology/*physiology
MH  - Symbiosis
EDAT- 2012/11/20 06:00
MHDA- 2013/09/21 06:00
CRDT- 2012/11/20 06:00
PHST- 2012/06/18 00:00 [received]
PHST- 2012/10/09 00:00 [revised]
PHST- 2012/10/09 00:00 [accepted]
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2013/09/21 06:00 [medline]
AID - S0022-1910(12)00254-5 [pii]
AID - 10.1016/j.jinsphys.2012.10.011 [doi]
PST - ppublish
SO  - J Insect Physiol. 2013 Feb;59(2):130-7. doi: 10.1016/j.jinsphys.2012.10.011. Epub
      2012 Nov 15.


PMID- 23158581
OWN - NLM
STAT- MEDLINE
DCOM- 20130219
LR  - 20211021
IS  - 0393-5264 (Print)
IS  - 0393-5264 (Linking)
VI  - 27
IP  - 2
DP  - 2012 Apr-Jun
TI  - Depressive symptoms among surrogate decision makers in Lebanese ICUs.
PG  - 95-9
AB  - Surrogate decision making is advocated to protect the vulnerable patient. Family 
      members of patients in intensive care units (ICUs) are prone to develop
      depressive symptoms which may undermine their decisional capacity. Lebanon is a
      multicultural country where paternalism still dominates the physician-patient
      relationship and ethics are far from being the subject of research and studies.
      This multicenter observational study in the Greater Beirut area attempts to
      estimate the prevalence of depressive symptoms among surrogates deciding on
      behalf of ICU patients and to correlate their severity with sociodemographic
      factors. During the period March-May 2011, direct interviews were conducted and
      the Patient Health Questionnaire-9 (PHQ-9) was administered to 56 family members 
      who had given consent, regarding therapeutic options, on behalf of ICU patients
      in seven university hospitals. We looked for relationships, in these surrogates, 
      between severity of depression and age, sex, marital status, level of education, 
      religion and status as the patient's spouse. The prevalence of major depression
      among surrogates was 61% using a cutoff of 10 on the PHQ-9 scale. Among the
      surrogates with depression, 15% had untreated moderate-to-severe depression.
      Severity of depression and suicidal ideation were not related to any of the
      studied factors. Depressive symptoms are prevalent among family members deciding 
      on behalf of ICU patients, rendering them vulnerable. Appropriate measures should
      be taken to identify and treat them.
FAU - Abou-Mrad, Fadi
AU  - Abou-Mrad F
AD  - Neurology Division, Saint Charles Hospital, Lebanese University, Beirut, Lebanon.
      fadiaboumrad@gmail.com
FAU - Mourad, Charbel
AU  - Mourad C
FAU - Najem, Catherine
AU  - Najem C
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - Italy
TA  - Funct Neurol
JT  - Functional neurology
JID - 8707746
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Decision Making
MH  - Depression/diagnosis/*epidemiology
MH  - Depressive Disorder/diagnosis/*epidemiology
MH  - Family/psychology
MH  - Female
MH  - Humans
MH  - *Intensive Care Units
MH  - Lebanon
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Proxy/*psychology
MH  - Psychiatric Status Rating Scales
MH  - Surveys and Questionnaires
PMC - PMC3812771
EDAT- 2012/11/20 06:00
MHDA- 2013/02/21 06:00
CRDT- 2012/11/20 06:00
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2013/02/21 06:00 [medline]
AID - 5529 [pii]
PST - ppublish
SO  - Funct Neurol. 2012 Apr-Jun;27(2):95-9.


PMID- 23158425
OWN - NLM
STAT- MEDLINE
DCOM- 20130905
LR  - 20131121
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 92
IP  - 31
DP  - 2012 Aug 21
TI  - [Effects of preloading epidural space with epinephrine (1:200 000) on the
      incidence of vascular injuries through the insertion of an epidural catheter
      during cesarean section].
PG  - 2195-7
AB  - OBJECTIVE: To evaluate the effects of preloading epidural space with epinephrine 
      (1:200 000) on the incidence of vascular injuries through the insertion of an
      epidural catheter during cesarean section. METHODS: Between May 2011 and December
      2011, upon obtaining institutional ethics approval and informed consent from the 
      Human Ethics Committee of Nanjing Medical University, 100 laboring women with
      singleton cephalic presentation at term, ASA (American Society of
      Anesthesiologists) class I-II, undergoing caesarean section under continuous
      epidural analgesia were randomly divided into E and N groups according to a
      random digit table (n = 50 each). After an identification of epidural space, 5 ml
      of normal saline with epinephrine (1:200 000) was injected into epidural space in
      group E and 5 ml of normal saline in group N through an epidural needle. The
      syringe plunger was pressed firmly for 20 seconds to ensure a sufficient
      diffusion. For both groups, the levels of mean arterial pressure and heart rates 
      were recorded prior to anesthesia (T1), 2 min after switching into a supine
      horizontal position after successful puncture (T2), the time of fetal delivery
      (T3) and when surgery was over (T4). The cases with bloody fluid in epidural
      puncture needle during puncture or epidural catheter during catheter placement,
      fresh blood in epidural catheter and bloody fluid in caudal end of epidural
      catheter during extubation were recorded. RESULTS: All hemodynamic changes were
      within the normal ranges. There were no obvious inter-group differences (P >
      0.05). No significant difference existed in the cases with bloody fluid in
      epidural needle during catheter insertion (10% vs 12%) or epidural catheter
      during catheter placement (4% vs 6%), fresh blood in epidural catheter (0% vs 0%)
      or bloody fluid in caudal end of epidural catheter during extubation (26% vs 30%)
      between the groups (P > 0.05). CONCLUSION: Preloading epidural space with
      epinephrine (1:200 000) may not lower the incidence of vascular injuries through 
      the insertion of an epidural catheter during cesarean section.
FAU - Han, Chuan-bao
AU  - Han CB
AD  - Department of Anesthesiology, First Affiliated Hospital, Nanjing Medical
      University, Nanjing 210029, China. mzhcb@yahoo.com.cn
FAU - Jiang, Xiu-hong
AU  - Jiang XH
FAU - Yu, Li
AU  - Yu L
FAU - Lin, Cong
AU  - Lin C
FAU - Ding, Zheng-nian
AU  - Ding ZN
FAU - Qian, Yan-ning
AU  - Qian YN
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Adult
MH  - Catheterization/*adverse effects
MH  - Cesarean Section/*adverse effects
MH  - Epidural Space/blood supply
MH  - Epinephrine/*administration & dosage/*pharmacology
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Pregnancy
MH  - Vascular System Injuries/*epidemiology/prevention & control
MH  - Young Adult
EDAT- 2012/11/20 06:00
MHDA- 2013/09/06 06:00
CRDT- 2012/11/20 06:00
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2013/09/06 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2012 Aug 21;92(31):2195-7.


PMID- 23158400
OWN - NLM
STAT- MEDLINE
DCOM- 20131211
LR  - 20211021
IS  - 0168-9525 (Print)
IS  - 0168-9525 (Linking)
VI  - 29
IP  - 2
DP  - 2013 Feb
TI  - Recent advances in the prenatal interrogation of the human fetal genome.
PG  - 84-91
LID - 10.1016/j.tig.2012.10.013 [doi]
LID - S0168-9525(12)00172-2 [pii]
AB  - The amount of genetic and genomic information obtainable from the human fetus
      during pregnancy is accelerating at an unprecedented rate. Two themes have
      dominated recent technological advances in prenatal diagnosis: interrogation of
      the fetal genome in increasingly high resolution and the development of
      non-invasive methods of fetal testing using cell-free DNA in maternal plasma.
      These two areas of advancement have now converged with several recent reports of 
      non-invasive assessment of the entire fetal genome from maternal blood. However, 
      technological progress is outpacing the ability of the healthcare providers and
      patients to incorporate these new tests into existing clinical care, and further 
      complicates many of the economic and ethical dilemmas in prenatal diagnosis. This
      review summarizes recent work in this field and discusses the integration of
      these new technologies into the clinic and society.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Hui, Lisa
AU  - Hui L
AD  - Mother Infant Research Institute at Tufts Medical Center, 800 Washington St, Box 
      394, Boston, MA 02111, USA. lisahui77@gmail.com
FAU - Bianchi, Diana W
AU  - Bianchi DW
LA  - eng
GR  - R01 HD042053/HD/NICHD NIH HHS/United States
GR  - HD42053-09/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20121115
PL  - England
TA  - Trends Genet
JT  - Trends in genetics : TIG
JID - 8507085
SB  - IM
MH  - Female
MH  - Fetal Diseases/*diagnosis/*genetics
MH  - Genome-Wide Association Study/*methods
MH  - Genomics/methods
MH  - Humans
MH  - Pregnancy
MH  - Prenatal Diagnosis/*methods
PMC - PMC4378900
MID - NIHMS673543
EDAT- 2012/11/20 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/11/20 06:00
PHST- 2012/09/07 00:00 [received]
PHST- 2012/10/10 00:00 [revised]
PHST- 2012/10/15 00:00 [accepted]
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - S0168-9525(12)00172-2 [pii]
AID - 10.1016/j.tig.2012.10.013 [doi]
PST - ppublish
SO  - Trends Genet. 2013 Feb;29(2):84-91. doi: 10.1016/j.tig.2012.10.013. Epub 2012 Nov
      15.


PMID- 23158028
OWN - NLM
STAT- MEDLINE
DCOM- 20130910
LR  - 20161125
IS  - 1399-0020 (Electronic)
IS  - 0901-5027 (Linking)
VI  - 42
IP  - 4
DP  - 2013 Apr
TI  - Do erupted third molars weaken the mandibular angle after trauma to the chin
      region? A 3D finite element study.
PG  - 474-80
LID - 10.1016/j.ijom.2012.10.009 [doi]
LID - S0901-5027(12)00422-5 [pii]
AB  - It has been suggested that third molars increase mandibular fragility because
      they do not contribute to its strength. For ethical reasons, a human study design
      that would permit the elucidation of this interference is not possible. This
      study evaluated the impact of the presence of erupted third molars on the
      mandibular angle of resistance when submitted to trauma. A three-dimensional (3D)
      mandibular model was obtained through finite element methodology using computed
      tomography (CT) with the geometry and mechanical properties to reproduce a normal
      mandibular structure. Human mandibles with no, one or two erupted third molars
      were evaluated. Whenever the third molar was present there was a greater
      concentration of tensions around the cervical part of its alveolus. Approximated 
      Von Mises equivalent stress of the third molar region was 107.035 MPa in the
      mandible with teeth and 64.6948 MPa in the mandible without teeth. In the
      condylar region it was 151.65 MPa when the third molar was present and 184.496
      MPa when it was absent. The digital models created proved that the mandibular
      angle becomes more fragile in the presence of third molars. When they are absent 
      the energy concentrates on the lateral e posterior aspect of the condylar neck.
CI  - Copyright (c) 2012 International Association of Oral and Maxillofacial Surgeons. 
      Published by Elsevier Ltd. All rights reserved.
FAU - Bezerra, T P
AU  - Bezerra TP
AD  - Post-Graduation Program in Dentistry of the Federal University of Ceara, St.
      Monsenhor Furtado, Ceara, Brazil. drtpb@hotmail.com
FAU - Silva Junior, F I
AU  - Silva Junior FI
FAU - Scarparo, H C
AU  - Scarparo HC
FAU - Costa, F W G
AU  - Costa FW
FAU - Studart-Soares, E C
AU  - Studart-Soares EC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121115
PL  - Denmark
TA  - Int J Oral Maxillofac Surg
JT  - International journal of oral and maxillofacial surgery
JID - 8605826
SB  - IM
MH  - Adult
MH  - Biomechanical Phenomena
MH  - Chin/diagnostic imaging/*injuries/physiopathology
MH  - Computer Simulation
MH  - Cone-Beam Computed Tomography
MH  - Dental Stress Analysis
MH  - Finite Element Analysis
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Imaging, Three-Dimensional
MH  - Male
MH  - Mandible/diagnostic imaging/*physiopathology
MH  - Mandibular Injuries/diagnostic imaging/*physiopathology
MH  - Models, Biological
MH  - *Molar, Third/diagnostic imaging
EDAT- 2012/11/20 06:00
MHDA- 2013/09/11 06:00
CRDT- 2012/11/20 06:00
PHST- 2012/05/31 00:00 [received]
PHST- 2012/08/03 00:00 [revised]
PHST- 2012/10/05 00:00 [accepted]
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2013/09/11 06:00 [medline]
AID - S0901-5027(12)00422-5 [pii]
AID - 10.1016/j.ijom.2012.10.009 [doi]
PST - ppublish
SO  - Int J Oral Maxillofac Surg. 2013 Apr;42(4):474-80. doi:
      10.1016/j.ijom.2012.10.009. Epub 2012 Nov 15.


PMID- 23157854
OWN - NLM
STAT- MEDLINE
DCOM- 20130211
LR  - 20211021
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 13
DP  - 2012 Nov 16
TI  - Pharmaceutical information systems and possible implementations of informed
      consent -- developing an heuristic.
PG  - 30
LID - 10.1186/1472-6939-13-30 [doi]
AB  - BACKGROUND: Denmark has implemented a comprehensive, nationwide pharmaceutical
      information system, and this system has been evaluated by the Danish Council of
      Ethics. The system can be seen as an exemplar of a comprehensive health
      information system for clinical use. ANALYSIS: The paper analyses 1) how informed
      consent can be implemented in the system and how different implementations create
      different impacts on autonomy and control of information, and 2) arguments
      directed towards justifying not seeking informed consent in this context. RESULTS
      AND CONCLUSION: Based on the analysis a heuristic is provided which enables a
      ranking and estimation of the impact on autonomy and control of information of
      different options for consent to entry of data into the system and use of data
      from the system.The danger of routinisation of consent is identified.The Danish
      pharmaceutical information system raises issues in relation to autonomy and
      control of information, issues that will also occur in relation to other similar 
      comprehensive health information systems. Some of these issues are well
      understood and their impact can be judged using the heuristic which is provided. 
      More research is, however needed in relation to routinisation of consent.
FAU - Ploug, Thomas
AU  - Ploug T
AD  - Centre for Applied Ethics and Philosophy of Science, Department of Communication,
      Aalborg University Copenhagen, A, C, Meyers Vaenge, 2450, Kobenhavn SV, Denmark. 
      ploug@hum.aau.dk
FAU - Holm, Soren
AU  - Holm S
LA  - eng
PT  - Journal Article
DEP - 20121116
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Beneficence
MH  - *Clinical Trials as Topic/ethics/methods/standards/trends
MH  - *Comprehension/ethics
MH  - Denmark
MH  - Ethics, Research
MH  - *Health Information Systems/ethics/organization & administration/standards/trends
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Personal Autonomy
MH  - *Pharmaceutical Preparations
MH  - *Principle-Based Ethics
MH  - Social Justice
PMC - PMC3507876
EDAT- 2012/11/20 06:00
MHDA- 2013/02/12 06:00
CRDT- 2012/11/20 06:00
PHST- 2012/04/26 00:00 [received]
PHST- 2012/10/17 00:00 [accepted]
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2013/02/12 06:00 [medline]
AID - 1472-6939-13-30 [pii]
AID - 10.1186/1472-6939-13-30 [doi]
PST - epublish
SO  - BMC Med Ethics. 2012 Nov 16;13:30. doi: 10.1186/1472-6939-13-30.


PMID- 23157698
OWN - NLM
STAT- MEDLINE
DCOM- 20130530
LR  - 20211021
IS  - 1755-5949 (Electronic)
IS  - 1755-5930 (Linking)
VI  - 19
IP  - 1
DP  - 2013 Jan
TI  - The next frontier in composite tissue allotransplantation.
PG  - 1-4
LID - 10.1111/cns.12029 [doi]
AB  - Solid organ transplantations became a clinical option in the 1950s. The hand
      allograft was the pioneer of composite tissue allotransplantation (CTA),
      successfully started near the end of the last century despite arguments over the 
      practicality and methods. Since then, CTA such as hand and face has continued to 
      progress from the theoretical to clinical reality. The treatment principles, drug
      combinations, and mechanisms of the immunosuppression medications on which
      contemporary transplant surgeries have been based continue to develop as
      researchers and physicians gain more experience in the CTA field. It could be
      argued that the ethical issues associated with CTA have prevented evolution of
      the field rather than surgical or technical skill. This is particularly true for 
      allo-head and body reconstruction (AHBR). How can leaders in the field of CTA
      develop a model that would satisfy ethical concerns? Bolstered by recent
      successes in the field, is it time to traverse the next frontier? Can AHBR ever
      be a feasible option in the clinical setting? The reader will be provided with a 
      brief history of CTA from theory to research to clinical practice. A concise
      description of AHBR as it pertains to the critical procedure (i.e., surgery
      design) will also be discussed.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Ren, Xiaoping
AU  - Ren X
AD  - Clinical Translational Medicine Center, Harbin Medical University, China.
      renxg@uc.edu
FAU - Laugel, Michael C
AU  - Laugel MC
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20121116
PL  - England
TA  - CNS Neurosci Ther
JT  - CNS neuroscience & therapeutics
JID - 101473265
SB  - IM
MH  - Animals
MH  - History, 20th Century
MH  - Humans
MH  - Spinal Cord Injuries/*surgery
MH  - Tissue Transplantation/history/*methods/*trends
MH  - Transplantation, Homologous/history/methods/trends
PMC - PMC6493418
EDAT- 2012/11/20 06:00
MHDA- 2013/06/01 06:00
CRDT- 2012/11/20 06:00
PHST- 2012/09/19 00:00 [received]
PHST- 2012/10/02 00:00 [revised]
PHST- 2012/10/02 00:00 [accepted]
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2013/06/01 06:00 [medline]
AID - 10.1111/cns.12029 [doi]
PST - ppublish
SO  - CNS Neurosci Ther. 2013 Jan;19(1):1-4. doi: 10.1111/cns.12029. Epub 2012 Nov 16.


PMID- 23157692
OWN - NLM
STAT- MEDLINE
DCOM- 20130524
LR  - 20151119
IS  - 1365-2036 (Electronic)
IS  - 0269-2813 (Linking)
VI  - 37
IP  - 2
DP  - 2013 Jan
TI  - Review article: towards a considered and ethical approach to organ support in
      critically-ill patients with cirrhosis.
PG  - 174-82
LID - 10.1111/apt.12133 [doi]
AB  - BACKGROUND: Increasing numbers of patients are being admitted to hospital with
      decompensated chronic liver disease in the UK. A significant proportion will
      develop complicating extra-hepatic organ dysfunction, but the selection of those 
      who should be admitted to intensive care is complex and challenging.
      Alcohol-related liver disease also presents complex ethical dilemmas. AIM: To
      review recent survival analyses and explore differences in secondary and tertiary
      care; to highlight strengths and weaknesses of prognostic models, therapeutic
      advances and shifts in prognostic expectation. We also aim to explore the ethical
      challenges presented by addiction and self-injury in an area of limited resource.
      METHODS: We searched PubMed for articles discussing 'cirrhosis', 'prognosis',
      'critical illness', 'organ failure', 'renal failure', 'alcohol', 'ethics' and
      'addiction'. We also explored particular ethical dilemmas encountered by the
      authors and colleagues. RESULTS: Prognosis has improved in many cirrhotic
      complications and historically poor outcomes in tertiary care may reflect a more 
      complex patient cohort. Previously 'untreatable' complications are now being
      managed successfully. Estimates of survival are more accurate after a 48-h period
      of supportive care. Physicians are not best placed to make judgments with regard 
      to deservingness, moral responsibility, rationing and access to organ support in 
      cases of acute deterioration related to alcoholism, and the case for denying
      support must be made on purely medical grounds. CONCLUSIONS: An early, aggressive
      approach to organ support is justified. Further discussions between hepatologists
      and critical care physicians are required to determine acceptable
      burden-to-benefit ratios for prolonged intensive care support in young alcoholic 
      patients.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Berry, P A
AU  - Berry PA
AD  - Frimley Park Hospital NHS Foundation Trust, Surrey, UK.
      philip.berry@fph-tr.nhs.uk
FAU - Thomson, S J
AU  - Thomson SJ
FAU - Rahman, T M
AU  - Rahman TM
FAU - Ala, A
AU  - Ala A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20121116
PL  - England
TA  - Aliment Pharmacol Ther
JT  - Alimentary pharmacology & therapeutics
JID - 8707234
SB  - IM
MH  - Alcohol Drinking/*adverse effects
MH  - Alcoholism/*complications
MH  - Attitude of Health Personnel
MH  - Critical Care/*ethics/standards
MH  - Humans
MH  - Intensive Care Units/*ethics/standards
MH  - Liver Cirrhosis/*therapy
MH  - Multiple Organ Failure/*therapy
MH  - Severity of Illness Index
MH  - Survival Analysis
EDAT- 2012/11/20 06:00
MHDA- 2013/05/28 06:00
CRDT- 2012/11/20 06:00
PHST- 2012/03/21 00:00 [received]
PHST- 2012/04/19 00:00 [revised]
PHST- 2012/10/17 00:00 [revised]
PHST- 2012/10/18 00:00 [accepted]
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2013/05/28 06:00 [medline]
AID - 10.1111/apt.12133 [doi]
PST - ppublish
SO  - Aliment Pharmacol Ther. 2013 Jan;37(2):174-82. doi: 10.1111/apt.12133. Epub 2012 
      Nov 16.


PMID- 23157450
OWN - NLM
STAT- MEDLINE
DCOM- 20131017
LR  - 20220409
IS  - 1548-5951 (Electronic)
IS  - 1548-5943 (Linking)
VI  - 9
DP  - 2013
TI  - Ambulatory assessment.
PG  - 151-76
LID - 10.1146/annurev-clinpsy-050212-185510 [doi]
AB  - Ambulatory assessment (AA) covers a wide range of assessment methods to study
      people in their natural environment, including self-report, observational, and
      biological/physiological/behavioral. AA methods minimize retrospective biases
      while gathering ecologically valid data from patients' everyday life in real time
      or near real time. Here, we report on the major characteristics of AA, and we
      provide examples of applications of AA in clinical psychology (a) to investigate 
      mechanisms and dynamics of symptoms, (b) to predict the future recurrence or
      onset of symptoms, (c) to monitor treatment effects, (d) to predict treatment
      success, (e) to prevent relapse, and (f) as interventions. In addition, we
      present and discuss the most pressing and compelling future AA applications:
      technological developments (the smartphone), improved ecological validity of
      laboratory results by combined lab-field studies, and investigating
      gene-environment interactions. We conclude with a discussion of acceptability,
      compliance, privacy, and ethical issues.
FAU - Trull, Timothy J
AU  - Trull TJ
AD  - Department of Psychological Sciences, University of Missouri, Columbia, Missouri 
      65211-1350, USA. trullt@missouri.edu
FAU - Ebner-Priemer, Ulrich
AU  - Ebner-Priemer U
LA  - eng
GR  - P60 AA011998/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20121113
PL  - United States
TA  - Annu Rev Clin Psychol
JT  - Annual review of clinical psychology
JID - 101235325
SB  - IM
MH  - Data Collection/instrumentation/*methods
MH  - Humans
MH  - *Mental Disorders/diagnosis/prevention & control/therapy
MH  - Monitoring, Ambulatory/instrumentation/*methods
MH  - Psychology, Clinical/instrumentation/*methods
PMC - PMC4249763
MID - NIHMS644723
EDAT- 2012/11/20 06:00
MHDA- 2013/10/18 06:00
CRDT- 2012/11/20 06:00
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2013/10/18 06:00 [medline]
AID - 10.1146/annurev-clinpsy-050212-185510 [doi]
PST - ppublish
SO  - Annu Rev Clin Psychol. 2013;9:151-76. doi: 10.1146/annurev-clinpsy-050212-185510.
      Epub 2012 Nov 13.


PMID- 23157067
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20121119
IS  - 0210-5020 (Print)
IS  - 0210-5020 (Linking)
VI  - 35
IP  - 10
DP  - 2012 Oct
TI  - [How to prepare the back home with baby in the maternal education programs in
      Madrid].
PG  - 24-30
AB  - JUSTIFICATION: To improve maternal and child health is important to work the
      postpartum familiar reorganization in the maternal education programs.
      OBJECTIVES: To know the scientific evidence of the postnatal care. To look for a 
      framework for nursing. To explore the educative strategies that midwives use in
      maternal education in Madrid (Spain). METHODS: Review of the evidence of prenatal
      and postnatal cares. Review of nursing models. Qualitative study. Probabilistic
      sample about 42 midwives of Primary Attention in Madrid that delivered programs
      of Maternal Education in 2011. Deep interviews. Interviews were coded and
      classified according to the method ofe based theory) through constant comparative
      analysis. Ethic and legal considerations. RESULTS: 14 clinic guides, 10 revisions
      and thousand of articles about postpartum care found. A theory of middle range
      found that allows to base nursing work in the familiar reorganization. 100% of
      midwives approached the topic and considered it very important. 36% of midwives
      worked with a case; 27% invited parents to a class; 14% showed the topic to
      pregnant woman; 11% used group dynamics; 7% through colloquium and 5% used cinema
      material. They did not use conceptual frameworks, neither specific evaluations,
      nor homework. CONCLUSION: Data allow us to know the scientific evidence, the
      approach that is performed in maternal education and new investigation proposals 
      to offer care of high quality.
FAU - Fernandez y Fernandez-Arroyo, Matilde
AU  - Fernandez y Fernandez-Arroyo M
AD  - Escuela Universitaria de Enfermeria de la Universidad Pontificia de Comillas.
      mfernandezarroyo@gmail.com
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Vuelta a casa con el bebe como se prepara en los programas de educacion maternal.
PL  - Spain
TA  - Rev Enferm
JT  - Revista de enfermeria (Barcelona, Spain)
JID - 8309920
MH  - Female
MH  - Humans
MH  - *Infant Care
MH  - Infant, Newborn
MH  - Mothers/*education
MH  - Spain
MH  - Urban Population
EDAT- 2012/11/20 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/11/20 06:00
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
PST - ppublish
SO  - Rev Enferm. 2012 Oct;35(10):24-30.


PMID- 23156656
OWN - NLM
STAT- MEDLINE
DCOM- 20130109
LR  - 20121119
IS  - 1320-159X (Print)
IS  - 1320-159X (Linking)
VI  - 20
IP  - 1
DP  - 2012 Sep
TI  - Avoiding a fate worse than death: an argument for legalising voluntary
      physician-based euthanasia.
PG  - 184-203
AB  - The legalisation of voluntary physician-based euthanasia is currently the subject
      of much political, social and ethical debate and there is evidence in Australia
      of growing support for its implementation. In addressing many of the issues that 
      surround legalisation, the article looks at some overseas jurisdictions that have
      legalised euthanasia to determine whether the social, political and ethical
      concerns prominent in the Australian debate have proved problematic in other
      jurisdictions. In addition, the article examines the report on the Dying with
      Dignity Bill 2009 (Tas) which commented extensively on the issues relating to
      voluntary physician-based euthanasia.
FAU - Werren, Julia
AU  - Werren J
AD  - Faculty of Law, University of New England. jwerren@une.edu.au
FAU - Yuksel, Necef
AU  - Yuksel N
FAU - Smith, Saxon
AU  - Smith S
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Law Med
JT  - Journal of law and medicine
JID - 9431853
SB  - IM
MH  - Euthanasia, Active, Voluntary/ethics/*legislation & jurisprudence
MH  - Humans
MH  - Netherlands
MH  - Personal Autonomy
MH  - Right to Die/legislation & jurisprudence
MH  - Suicide, Assisted/ethics/legislation & jurisprudence
MH  - Switzerland
MH  - United States
EDAT- 2012/11/20 06:00
MHDA- 2013/01/10 06:00
CRDT- 2012/11/20 06:00
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2013/01/10 06:00 [medline]
PST - ppublish
SO  - J Law Med. 2012 Sep;20(1):184-203.


PMID- 23156653
OWN - NLM
STAT- MEDLINE
DCOM- 20130109
LR  - 20121119
IS  - 1320-159X (Print)
IS  - 1320-159X (Linking)
VI  - 20
IP  - 1
DP  - 2012 Sep
TI  - Reappraising consent: conducting ethical psychiatric research in Singapore.
PG  - 152-64
AB  - Singapore is legally restrictive when it comes to research involving minors. The 
      age of majority is 21 and parental consent is required for participation in
      medical research. This article explores the age of majority and the issues
      related to obtaining consent for research in Singapore, focusing on "young
      adults" (17-21 years), using an example of a translational and clinical research 
      project called the Longitudinal Youth at Risk Study (LYRIKS). It describes the
      unique legal and social conditions pertaining to the age of majority in
      Singapore, before presenting an argument for consideration as to whether the age 
      of consent to participate in research should be reviewed. It concludes that
      rather than a set of doctrinaire rules for the age of participation in research, 
      there should be an assessment of the kind of tasks that minors can assume
      themselves in respect to a specific project, and the degree of parental
      involvement.
FAU - Rekhi, Gurpreet
AU  - Rekhi G
AD  - Research Division, Institute of Mental Health/Woodbridge Hospital, Singapore.
      Gurpreet_Rekhi@imh.com.sg
FAU - Capps, Benjamin
AU  - Capps B
FAU - Lysaght, Tamra
AU  - Lysaght T
FAU - Chong, Siow Ann
AU  - Chong SA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - J Law Med
JT  - Journal of law and medicine
JID - 9431853
SB  - IM
MH  - Adolescent
MH  - Biomedical Research/ethics/*legislation & jurisprudence
MH  - *Ethics, Research
MH  - Humans
MH  - Informed Consent/ethics
MH  - Minors/*legislation & jurisprudence
MH  - Psychiatry
MH  - Singapore
MH  - Young Adult
EDAT- 2012/11/20 06:00
MHDA- 2013/01/10 06:00
CRDT- 2012/11/20 06:00
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2013/01/10 06:00 [medline]
PST - ppublish
SO  - J Law Med. 2012 Sep;20(1):152-64.


PMID- 23156651
OWN - NLM
STAT- MEDLINE
DCOM- 20130109
LR  - 20211021
IS  - 1320-159X (Print)
IS  - 1320-159X (Linking)
VI  - 20
IP  - 1
DP  - 2012 Sep
TI  - Criticisms of African trials fail to withstand scrutiny: male circumcision does
      prevent HIV infection.
PG  - 93-123
AB  - A recent article in the JLM (Boyle GJ and Hill G, "Sub-Saharan African Randomised
      Clinical Trials into Male Circumcision and HIV Transmission: Methodological,
      Ethical and Legal Concerns" (2011) 19 JLM 316) criticises the large randomised
      controlled trials (RCTs) that scientists, clinicians and policy-makers worldwide 
      have concluded provide compelling evidence in support of voluntary medical male
      circumcision (VMMC) as an effective HIV prevention strategy. The present article 
      addresses the claims advanced by Boyle and Hill, demonstrating their reliance on 
      outmoded evidence, outlier studies, and flawed statistical analyses. In the
      current authors' view, their claims portray misunderstandings of the design,
      execution and interpretation of findings from RCTs in general and of the
      epidemiology of HIV transmission in sub-Saharan Africa in particular. At the same
      time they ignore systematic reviews and meta-analyses using all available data
      arising from good-quality research studies, including RCTs. Denial of the
      evidence supporting lack of male circumcision as a major determinant of HIV
      epidemic patterns in sub-Saharan Africa is unsubstantiated and risks undermining 
      the evidence-based, large-scale roll-out of VMMC for HIV prevention currently
      underway. The present article highlights the quality, consistency and robustness 
      of the scientific evidence that underpins the public health recommendations,
      guidance, and tools on VMMC. Millions of HIV infections will be averted in the
      coming decades as VMMC services scale-up to meet demand, providing direct
      benefits for heterosexual men and indirect benefits for their female partners.
FAU - Wamai, Richard G
AU  - Wamai RG
AD  - Department of African-American Studies, Northeastern University, Boston,
      Massachusetts, United States of America. r.wamai@neu.edu
FAU - Morris, Brian J
AU  - Morris BJ
FAU - Waskett, Jake H
AU  - Waskett JH
FAU - Green, Edward C
AU  - Green EC
FAU - Banerjee, Joya
AU  - Banerjee J
FAU - Bailey, Robert C
AU  - Bailey RC
FAU - Klausner, Jeffrey D
AU  - Klausner JD
FAU - Sokal, David C
AU  - Sokal DC
FAU - Hankins, Catherine A
AU  - Hankins CA
LA  - eng
GR  - P30 AI082151/AI/NIAID NIH HHS/United States
PT  - Journal Article
PL  - Australia
TA  - J Law Med
JT  - Journal of law and medicine
JID - 9431853
SB  - IM
MH  - Africa South of the Sahara
MH  - *Circumcision, Male
MH  - HIV Infections/*prevention & control/*transmission
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - Randomized Controlled Trials as Topic
MH  - *Research Design
EDAT- 2012/11/20 06:00
MHDA- 2013/01/10 06:00
CRDT- 2012/11/20 06:00
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2013/01/10 06:00 [medline]
PST - ppublish
SO  - J Law Med. 2012 Sep;20(1):93-123.


PMID- 23156649
OWN - NLM
STAT- MEDLINE
DCOM- 20130109
LR  - 20121119
IS  - 1320-159X (Print)
IS  - 1320-159X (Linking)
VI  - 20
IP  - 1
DP  - 2012 Sep
TI  - The dollars and sense of restraints and seclusion.
PG  - 73-81
AB  - Restraints and seclusion are a common practice in many human service settings
      despite the increasing evidence questioning their efficacy and appropriateness.
      There are many detrimental effects on people subject to these practices, such as 
      falls, injury, psychological trauma and even death. In addition to the impact on 
      people being served, there is also a range of negative effects on organisations
      and the workforce. This article outlines and discusses the costs to organisations
      in implementing restraints and seclusion, and the economic cost-benefits to be
      gained in working towards the safe elimination of restraints and seclusion. A
      brief outline of ethical alternatives to restraints and seclusion is explored.
      The emerging research evidence suggests that it is possible to achieve the safe
      elimination of restraints and seclusion in a human service organisation.
FAU - Chan, Jeffrey
AU  - Chan J
AD  - Department of Communities, Queensland, Australia.
      Jeffrey.chan@communities.qld.gov.au
FAU - LeBel, Janice
AU  - LeBel J
FAU - Webber, Lynne
AU  - Webber L
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Law Med
JT  - Journal of law and medicine
JID - 9431853
SB  - IM
MH  - Cost-Benefit Analysis
MH  - Humans
MH  - Patient Isolation/economics/*ethics
MH  - Restraint, Physical/*ethics
MH  - Safety Management
EDAT- 2012/11/20 06:00
MHDA- 2013/01/10 06:00
CRDT- 2012/11/20 06:00
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2013/01/10 06:00 [medline]
PST - ppublish
SO  - J Law Med. 2012 Sep;20(1):73-81.


PMID- 23156647
OWN - NLM
STAT- MEDLINE
DCOM- 20130109
LR  - 20181202
IS  - 1320-159X (Print)
IS  - 1320-159X (Linking)
VI  - 20
IP  - 1
DP  - 2012 Sep
TI  - Civil liberties and the critics of safe vaccination: Australian Vaccination
      Network Inc v Health Care Complaints Commission [2012] NSWSC 110.
PG  - 44-58
AB  - Public immunisation programs have, time and again, demonstrated their
      effectiveness at reducing mortality and morbidity from vaccine-preventable
      diseases such as measles and pertussis. Governments, health agencies and almost
      all health practitioners regard vaccines as safe and cost-effective treatments
      with a low risk profile. Nevertheless, despite, or perhaps because of, their
      success, immunisation programs and vaccines have increasingly been questioned by 
      various lobby groups, sceptical of the safety of vaccines and the motives of
      those who administer them. Whereas the reach of these groups would have once been
      limited by the cost of postage, the internet has delivered a global audience. The
      extent to which these anti-vaccination advocates are expected to comply with the 
      ethical and professional standards applied to registered health professionals
      remains unresolved in Australia. As demonstrated in the case of Australian
      Vaccination Network Inc v Health Care Complaints Commission [2012] NSWSC 110, the
      ability of professional oversight bodies to regulate the information promoted by 
      these lobby groups is limited by traditional conceptions of the doctor-patient
      relationship and the clinical setting in which medical advice is delivered.
      Acknowledging that vaccines, like all medical treatments, involve some level of
      risk, this article explores the relationship between the state, parents, family, 
      medical professionals and such lobbyists within a human rights framework,
      suggesting that most public immunisation programs deliver benefits in "the best
      interest of the child" that, on balance, provide a good result for the civil
      liberties of Australians.
FAU - Vines, Tim
AU  - Vines T
AD  - College of Law, Australian National University.
FAU - Faunce, Thomas
AU  - Faunce T
LA  - eng
PT  - Journal Article
PT  - Legal Case
PL  - Australia
TA  - J Law Med
JT  - Journal of law and medicine
JID - 9431853
SB  - IM
MH  - Australia
MH  - Consumer Product Safety/*legislation & jurisprudence
MH  - Human Rights/*legislation & jurisprudence
MH  - Humans
MH  - *Lobbying
MH  - Vaccination/*legislation & jurisprudence
EDAT- 2012/11/20 06:00
MHDA- 2013/01/10 06:00
CRDT- 2012/11/20 06:00
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2013/01/10 06:00 [medline]
PST - ppublish
SO  - J Law Med. 2012 Sep;20(1):44-58.


PMID- 23156646
OWN - NLM
STAT- MEDLINE
DCOM- 20130109
LR  - 20121119
IS  - 1320-159X (Print)
IS  - 1320-159X (Linking)
VI  - 20
IP  - 1
DP  - 2012 Sep
TI  - A fair dinkum duty of open disclosure following medical error.
PG  - 35-43
AB  - Supporting patients and families in circumstances where medical error has caused 
      significant harm is said to be governed by the principles of ordinary treatment: 
      honest, open communication, empathy and respect. By and large, harmed patients
      look for acknowledgment of the events that occurred including errors, acceptance 
      of responsibility, a sincere apology, and assurance that lessons learned will be 
      put to preventive use. Australia's National Open Disclosure Standard purports to 
      respond to these reasonable expectations, yet it advises health care
      professionals that while they may express regret for what has occurred, they
      should take care not to state or agree that they, or other health care
      professionals, or health care organisations, are liable for the harm caused to
      the patient. The National Open Disclosure Standard is currently being reviewed,
      and the Consultation Draft of the Australian Open Disclosure Framework appears to
      move things closer to its stated finding that ethical practice prioritises
      organisational and individual learning from error, rather than an organisational 
      risk-management approach. However, it remains the case that the sense of apology 
      in the Consultation Draft is one of stating regret, not of accepting
      responsibility This dissonance in the Draft Framework wording may represent a
      continuing disingenuousness on the part of health professionals and their
      institutions regarding the kind of apologies that patients look for. Following
      Berlinger, the current author argues that expressions of regret are not
      apologies, since an apology presupposes the fault that health professionals are
      advised they avoid admitting. But honest, open communication surely implies both 
      materially relevant disclosure, which would include acknowledgment of fault where
      that is known, and a genuine apology, as part of the continuing doctor-patient
      relationship. To the extent that open disclosure policies and practices fudge
      complete disclosure, admission of fault and genuine apology, they remain
      deficient instruments in the respect and beneficence owed patients harmed by
      health care. Advice to health care professionals to not admit fault, and
      implicitly to not apologise genuinely, are motivated by legal liability
      considerations. There is strong evidence that comprehensive communication,
      including genuine apology and consistent with the medical ethical principle of
      veracity, is associated with reduced levels of litigation. State health
      department Open Disclosure policies and State and Territory civil liability
      legislation should be reviewed to remove obfuscatory and dissembling language and
      increase consistency between jurisdictions and between policies and statutes. The
      National Open Disclosure Standard should be revised to encourage and support full
      disclosure and genuine apology. If these processes fail, statutory reform should 
      be considered.
FAU - Parker, Malcolm
AU  - Parker M
AD  - University of Queensland. m.parker@uq.edu.au
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Law Med
JT  - Journal of law and medicine
JID - 9431853
SB  - IM
MH  - Australia
MH  - Humans
MH  - Liability, Legal
MH  - Medical Errors/ethics/*legislation & jurisprudence
MH  - Truth Disclosure/*ethics
EDAT- 2012/11/20 06:00
MHDA- 2013/01/10 06:00
CRDT- 2012/11/20 06:00
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2013/01/10 06:00 [medline]
PST - ppublish
SO  - J Law Med. 2012 Sep;20(1):35-43.


PMID- 23156635
OWN - NLM
STAT- MEDLINE
DCOM- 20121204
LR  - 20161125
IS  - 8750-2186 (Print)
IS  - 8750-2186 (Linking)
VI  - 31
IP  - 10
DP  - 2012 Oct
TI  - The new age of ethical cosmetic dentistry: implementing the concept of
      progressive smile design.
PG  - 98-101
FAU - Qureshi, Tif
AU  - Qureshi T
AD  - British Academy of Cosmetic Dentistry. tifqureshi@mac.com
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Dent Today
JT  - Dentistry today
JID - 9005357
RN  - 0 (Composite Resins)
MH  - Composite Resins/chemistry
MH  - Crowns
MH  - Dental Prosthesis Design
MH  - Dental Restoration, Permanent/*ethics
MH  - Dental Veneers
MH  - *Esthetics, Dental
MH  - *Ethics, Dental
MH  - Female
MH  - Gingiva/pathology
MH  - Humans
MH  - Incisor/pathology
MH  - Malocclusion/therapy
MH  - Orthodontic Anchorage Procedures/instrumentation
MH  - Orthodontic Appliance Design
MH  - Orthodontic Retainers
MH  - *Smiling
MH  - Tooth Bleaching/methods
MH  - Tooth Discoloration/therapy
MH  - Tooth Movement Techniques/instrumentation
EDAT- 2012/11/20 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/11/20 06:00
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
PST - ppublish
SO  - Dent Today. 2012 Oct;31(10):98-101.


PMID- 23156015
OWN - NLM
STAT- MEDLINE
DCOM- 20121211
LR  - 20181202
IS  - 0008-4581 (Print)
IS  - 0008-4581 (Linking)
VI  - 108
IP  - 8
DP  - 2012 Oct
TI  - Get on board with the research ethics review process.
PG  - 28-33
FAU - Cummings, Lynn
AU  - Cummings L
AD  - Vancouver Island Health Authority Health Research Ethics Board.
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Nurse
JT  - The Canadian nurse
JID - 0405504
MH  - Canada
MH  - Ethics Committees, Research/*statistics & numerical data
MH  - Humans
MH  - Nursing Research/*ethics
MH  - Therapeutic Human Experimentation/*ethics
EDAT- 2012/11/20 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/11/20 06:00
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
PST - ppublish
SO  - Can Nurse. 2012 Oct;108(8):28-33.


PMID- 23155755
OWN - NLM
STAT- MEDLINE
DCOM- 20130122
LR  - 20181202
IS  - 0039-4564 (Print)
IS  - 0039-4564 (Linking)
VI  - 96
IP  - 1
DP  - 2012
TI  - ["With all measures...". Appeal proceedings and political specialty disputes
      about orthopedics at the Berlin University and the Charite during the time of the
      Kaiser Empire, the Weimar Republic and national socialism].
PG  - 1-27
AB  - In 1934 the NSDAP University-Commission forced the president of the German
      Society of Surgery and the chairman of the German Orthopaedic Society to sign a
      reconciliation agreement. First of all, orthopaedists and surgeons were ordered
      to refrain from attacking each other in public. In the future, in the event of
      any complaints, they were to address the 'Reichsarztefuhrung' at the Ministry of 
      the Interior. On the basis of papers and documents from the archives of the
      medical faculty, the East German Ministry for State Security and the former
      Berlin Document Centre, this article describes the history of the emerging
      medical specialty orthopaedics at the University of Berlin and the Charite
      hospital. It covers a period from 1890 through 1945 and focuses on the varying
      relations between political authorities, medical associations and the faculty.
      The main attention is given to ethical and economic disputes and to the way in
      which professors for orthopaedics were appointed. The two pioneers of orthopaedic
      surgery, Julius Wolff and Albert Hoffa had to overcome less resistance than their
      successors Georg Joachimsthal and Hermann Gocht. Gocht's fate changed, when the
      NSDAP took Power. As a protege of the regime he represented the medical faculty
      during the period of political cleansing. In 1937 the appointment of the
      orthopaedist Lothar Kreuz as a full member of the medical faculty was no longer a
      university matter anymore. His appointment was negotiated entirely within the
      organisations of the NSDAP. Politically approved, Kreuz served as dean of the
      medical faculty and later was to be the last rector of the University of Berlin. 
      For the first time, this article documents the connections between Kreuz, the
      paramilitary squadron of the party SS, and key political figures.
FAU - Philipp, Osten
AU  - Philipp O
AD  - Institut fur Geschichte und Ethik der Medizin, der Ruprecht-Karls-Universitit
      Heidelberg, Im Neuenheimer Feld 327. 69120 Heidelberg. osten@uni-heidelberg.de
LA  - ger
PT  - Biography
PT  - Historical Article
PT  - Journal Article
PT  - Portrait
TT  - "Mit allen Mitteln..." Berufungsverfahren und fachpolitische Auseinandersetzungen
      um die Orthopadie an Berliner Universitat und Charite in der Zeit des
      Kaiserreichs, der Weimarer Republik und des Nationalsozialismus.
PL  - Germany
TA  - Sudhoffs Arch
JT  - Sudhoffs Archiv
JID - 0240376
SB  - IM
MH  - Adult
MH  - Aged
MH  - Child
MH  - Child, Preschool
MH  - Disabled Children/*history
MH  - Eugenics/*history
MH  - Faculty, Medical/*history
MH  - Germany
MH  - History, 15th Century
MH  - History, 16th Century
MH  - History, 18th Century
MH  - History, 19th Century
MH  - History, 20th Century
MH  - Hospitals, University/*history
MH  - Humans
MH  - Infant
MH  - National Socialism/*history
MH  - Orthopedics/*history
MH  - Political Systems/*history
MH  - *Politics
PS  - Kreuz L
FPS - Kreuz, Lothar
EDAT- 2012/11/20 06:00
MHDA- 2013/01/23 06:00
CRDT- 2012/11/20 06:00
PHST- 2012/11/20 06:00 [entrez]
PHST- 2012/11/20 06:00 [pubmed]
PHST- 2013/01/23 06:00 [medline]
PST - ppublish
SO  - Sudhoffs Arch. 2012;96(1):1-27.


PMID- 23154524
OWN - NLM
STAT- MEDLINE
DCOM- 20131022
LR  - 20220210
IS  - 1530-0366 (Electronic)
IS  - 1098-3600 (Linking)
VI  - 15
IP  - 5
DP  - 2013 May
TI  - Ethical dilemmas associated with genetic testing: which are most commonly seen
      and how are they managed?
PG  - 345-53
LID - 10.1038/gim.2012.138 [doi]
AB  - PURPOSE: The aim of this study was to document the range and frequency of ethical
      dilemmas associated with genetic testing encountered by genetic health
      professionals and to determine the strategies used to manage them. METHODS: An
      online survey was used to document how often the 11 key ethical dilemmas have
      been encountered; whether any additional dilemmas have been encountered; and how 
      these dilemmas have been managed. Members of the Australasian Association of
      Clinical Geneticists, Australasian Society of Genetic Counsellors, and genetic
      social workers practicing in Australia and New Zealand were invited to
      participate. RESULTS: A total of 102 responses were received (31% response rate).
      Respondents had encountered all of the 11 ethical dilemmas included in the
      survey, and 18 respondents had encountered 14 additional dilemmas. Respondents
      encountered an average of 2.2 dilemmas per year of practice. Peer and clinical
      supervision were the most common strategies used to manage dilemmas, and seeking 
      advice from clinical ethics committees was rare. Occasionally, respondents
      facilitated practices they deemed unethical as a consequence of client deception.
      CONCLUSION: Ethical dilemmas of genetic testing are encountered regularly in
      clinical genetics practice. Evidence provided by our study can assist in
      targeting training, support, and guidance to help genetic health professionals
      navigate such dilemmas in the future.
FAU - McLean, Natalie
AU  - McLean N
AD  - Department of Paediatrics, University of Melbourne, Parkville, Victoria,
      Australia.
FAU - Delatycki, Martin B
AU  - Delatycki MB
FAU - Macciocca, Ivan
AU  - Macciocca I
FAU - Duncan, Rony E
AU  - Duncan RE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121115
PL  - United States
TA  - Genet Med
JT  - Genetics in medicine : official journal of the American College of Medical
      Genetics
JID - 9815831
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Genetic Testing/*ethics
MH  - Health Care Surveys
MH  - Health Personnel
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2012/11/17 06:00
MHDA- 2013/10/23 06:00
CRDT- 2012/11/17 06:00
PHST- 2012/11/17 06:00 [entrez]
PHST- 2012/11/17 06:00 [pubmed]
PHST- 2013/10/23 06:00 [medline]
AID - S1098-3600(21)02029-3 [pii]
AID - 10.1038/gim.2012.138 [doi]
PST - ppublish
SO  - Genet Med. 2013 May;15(5):345-53. doi: 10.1038/gim.2012.138. Epub 2012 Nov 15.


PMID- 23154440
OWN - NLM
STAT- MEDLINE
DCOM- 20130117
LR  - 20121116
IS  - 1948-965X (Electronic)
IS  - 1682-3141 (Linking)
VI  - 20
IP  - 4
DP  - 2012 Dec
TI  - Qualitative assessment of a blended learning intervention in an undergraduate
      nursing course.
PG  - 291-9
LID - 10.1097/jnr.0b013e31827363bc [doi]
AB  - BACKGROUND: Nurses are experiencing new ethical issues because of global
      developments and changes in the healthcare environment. Blended learning is one
      of the various methods used to deliver meaningful learning experiences.
      Well-designed, properly administered nursing ethics education is essential for
      nursing students to visualize the role of professional nurses. However, a
      literature review shows that only a few existing studies have touched on the
      subject of nursing student experiences with blended learning in a nursing ethics 
      course. PURPOSE: This study examines how undergraduate nursing students respond
      to a blended learning approach in a nursing ethics course and how blended
      learning affects the learning process. METHODS: We used a qualitative research
      design with in-depth interviews. Participants included 28 female undergraduate
      nursing students who had completed the nursing ethics course. Each interview
      lasted 50-100 minutes. The researcher conducted all interviews in 2009. RESULTS: 
      The researcher identified six major themes and 13 subthemes from the data. The
      six themes included (a) enhancing thinking ability, (b) improving problem-solving
      skills, (c) reflecting in and on practice, (d) perceiving added workload, (e)
      encouraging active learning, and (f) identifying the value of nursing.
      Participants felt that the blended learning experience was a generally positive
      experience. CONCLUSION: Most participants appreciated the opportunity to take a
      more active role in the learning process, think about issues profoundly and
      critically, and exercise metacognitive powers in the thinking and decision-making
      process. Study findings may suggest productive ideas for fine-tuning blended
      learning models.
FAU - Hsu, Li-Ling
AU  - Hsu LL
AD  - Graduate Institute of Health Allied Education, National Taipei University of
      Nursing and Health Sciences. llhsu@ntunhs.edu.tw
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China (Republic : 1949- )
TA  - J Nurs Res
JT  - The journal of nursing research : JNR
JID - 101128757
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Curriculum
MH  - Education, Nursing, Baccalaureate/*methods
MH  - Ethics, Nursing/*education
MH  - Female
MH  - Humans
MH  - *Learning
MH  - Nursing Education Research
MH  - Nursing Evaluation Research
MH  - Nursing Methodology Research
MH  - Qualitative Research
MH  - Students, Nursing/*psychology
EDAT- 2012/11/17 06:00
MHDA- 2013/01/18 06:00
CRDT- 2012/11/17 06:00
PHST- 2012/11/17 06:00 [entrez]
PHST- 2012/11/17 06:00 [pubmed]
PHST- 2013/01/18 06:00 [medline]
AID - 10.1097/jnr.0b013e31827363bc [doi]
AID - 00134372-201212000-00008 [pii]
PST - ppublish
SO  - J Nurs Res. 2012 Dec;20(4):291-9. doi: 10.1097/jnr.0b013e31827363bc.


PMID- 23154319
OWN - NLM
STAT- MEDLINE
DCOM- 20130513
LR  - 20210820
IS  - 1527-3172 (Electronic)
IS  - 1527-3172 (Linking)
VI  - 14
IP  - 4
DP  - 2012 Oct
TI  - Community engagement, personal responsibility and self help in Cuba's health
      system reform.
PG  - 44-7
LID - 10.37757/MR2012V14.N4.11 [doi]
AB  - In 2011 the Cuban health system began a process of sectoral reform to maintain
      and improve the health of Cuba's population, in response to new challenges and
      demands in the health sector and population health status. The main actions
      involved are reorganization, consolidation and regionalization of services and
      resources. Although community engagement and personal responsibility are not
      explicitly mentioned in the strategy document, it is advisable to use this
      opportunity to revitalize both topics and encourage appropriate and full
      incorporation into the Cuban health system. Both are consistent with the
      objectives and actions of system reforms proposed, in that they allow the various
      social actors to assume shared responsibility in working toward social goals--in 
      this case, health gains. This approach also recognizes that reaching such goals
      is a collective endeavor, to be pursued according to ethical principles
      (beneficence as responsibility and justice as solidarity), with community
      involvement and personal responsibility emerging as two important factors subject
      to reorientation in the context of the health system reform under way.
FAU - Luis, Isabel P
AU  - Luis IP
AD  - National Hygiene, Epidemiology and Microbiology Institute (INHEM), Havana, Cuba. 
      isapi@inhem.sld.cu
FAU - Martinez, Silvia
AU  - Martinez S
FAU - Alvarez, Adolfo
AU  - Alvarez A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - MEDICC Rev
JT  - MEDICC review
JID - 100964771
SB  - IM
MH  - *Community Networks
MH  - Cuba
MH  - Delivery of Health Care/*organization & administration
MH  - *Health Care Reform
MH  - Humans
MH  - *Self Care
MH  - *Social Responsibility
EDAT- 2012/11/17 06:00
MHDA- 2013/05/15 06:00
CRDT- 2012/11/17 06:00
PHST- 2012/11/17 06:00 [entrez]
PHST- 2012/11/17 06:00 [pubmed]
PHST- 2013/05/15 06:00 [medline]
AID - 10.37757/MR2012V14.N4.11 [doi]
PST - ppublish
SO  - MEDICC Rev. 2012 Oct;14(4):44-7. doi: 10.37757/MR2012V14.N4.11.


PMID- 23153824
OWN - NLM
STAT- MEDLINE
DCOM- 20141223
LR  - 20220331
IS  - 1873-2550 (Electronic)
IS  - 0304-4017 (Linking)
VI  - 192
IP  - 1-3
DP  - 2013 Feb 18
TI  - Canine visceral leishmaniasis: a comparative study of real-time PCR, conventional
      PCR, and direct agglutination on sera for the detection of Leishmania infantum
      infection.
PG  - 83-90
LID - 10.1016/j.vetpar.2012.10.013 [doi]
LID - S0304-4017(12)00560-2 [pii]
AB  - Canine visceral leishmaniasis (CVL) is endemic in northwestern Iran. This study
      aimed to compare real-time PCR, conventional PCR, and the direct agglutination
      test (DAT) for the diagnosis Leishmania infantum infection in 167 serum samples
      of domestic dog. Bone marrow was used for parasitological examination (smears
      and/or culture) in symptomatic visceral leishmaniasis, and serum was used for
      detection of L. infantum kinetoplast DNA (kDNA) by both conventional PCR and
      real-time PCR, while anti-L. infantum antibodies in sera were measured by DAT.
      The sera were collected from 37 symptomatic and 112 asymptomatic dogs during
      April to May 2011. Eighteen presumed negative samples were obtained from healthy 
      dogs kept in non-endemic areas with no history of CVL and used as controls. All
      18 samples were negative by DAT and Dipstick rK39. DAT confirmed previous
      exposure to L. infantum for all 149 serum samples collected from symptomatic and 
      asymptomatic dogs in CVL endemic areas of Iran. Among the 37 symptomatic dogs, 20
      (54%), 25 (67.6%), 36 (97.3%), and 37 (100%) showed L. infantum infection by
      parasitological methods, conventional PCR, real-time PCR, and DAT (>/= 1:80),
      respectively. Of 112 asymptomatic dogs, 79 (70.5%), 111 (99.1%), and 112 (100%)
      were shown to be positive by conventional PCR, and DAT (>/= 1:80), respectively. 
      For ethical reasons, no asymptomatic or healthy control dogs were examined by
      parasitological methods. Three (16.7%) control dogs were positive by real-time
      PCR, but were negative by DAT, dipstick rK39, and conventional PCR methods.
      Parasitemia levels were measured by real-time PCR targeting kDNA using SYBR((R)) 
      green assay. This quantitative technique detected infection in 89.9% (150/167) of
      the domestic dogs that harbored L. infantum kDNA, ranging from 0.01 49 to 310.1
      parasites/ml. The average was 16.60 parasites/ml. A good agreement (0.97) was
      found between real-time PCR and DAT at >/= 1:80 titer, used as cut-off value by
      Kappa analysis. Thus, real-time PCR as a quantitative PCR assay on serum samples 
      represents a valuable tool for initial diagnosis of CVL when whole blood is not
      available.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Mohammadiha, A
AU  - Mohammadiha A
AD  - Department of Medical Parasitology & Mycology, School of Medicine, Shahid
      Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Haghighi, A
AU  - Haghighi A
FAU - Mohebali, M
AU  - Mohebali M
FAU - Mahdian, R
AU  - Mahdian R
FAU - Abadi, A R
AU  - Abadi AR
FAU - Zarei, Z
AU  - Zarei Z
FAU - Yeganeh, F
AU  - Yeganeh F
FAU - Kazemi, B
AU  - Kazemi B
FAU - Taghipour, N
AU  - Taghipour N
FAU - Akhoundi, B
AU  - Akhoundi B
FAU - Barati, M
AU  - Barati M
FAU - Mahmoudi, M R
AU  - Mahmoudi MR
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121026
PL  - Netherlands
TA  - Vet Parasitol
JT  - Veterinary parasitology
JID - 7602745
RN  - 0 (Antibodies, Protozoan)
RN  - 0 (Antigens, Protozoan)
RN  - 0 (DNA, Kinetoplast)
RN  - 0 (DNA, Protozoan)
SB  - IM
MH  - Agglutination Tests/*veterinary
MH  - Animals
MH  - Antibodies, Protozoan/immunology
MH  - Antigens, Protozoan/immunology
MH  - Asymptomatic Diseases
MH  - Bone Marrow/parasitology
MH  - DNA, Kinetoplast/blood/genetics
MH  - DNA, Protozoan/blood/genetics
MH  - Dog Diseases/*diagnosis/immunology/parasitology
MH  - Dogs
MH  - Iran/epidemiology
MH  - Leishmania infantum/genetics/immunology/*isolation & purification
MH  - Leishmaniasis, Visceral/diagnosis/immunology/*veterinary
MH  - Polymerase Chain Reaction/*veterinary
MH  - Real-Time Polymerase Chain Reaction/veterinary
MH  - Sensitivity and Specificity
EDAT- 2012/11/17 06:00
MHDA- 2014/12/24 06:00
CRDT- 2012/11/17 06:00
PHST- 2012/01/11 00:00 [received]
PHST- 2012/10/08 00:00 [revised]
PHST- 2012/10/11 00:00 [accepted]
PHST- 2012/11/17 06:00 [entrez]
PHST- 2012/11/17 06:00 [pubmed]
PHST- 2014/12/24 06:00 [medline]
AID - S0304-4017(12)00560-2 [pii]
AID - 10.1016/j.vetpar.2012.10.013 [doi]
PST - ppublish
SO  - Vet Parasitol. 2013 Feb 18;192(1-3):83-90. doi: 10.1016/j.vetpar.2012.10.013.
      Epub 2012 Oct 26.


PMID- 23153559
OWN - NLM
STAT- MEDLINE
DCOM- 20130219
LR  - 20130101
IS  - 1096-0333 (Electronic)
IS  - 0041-008X (Linking)
VI  - 266
IP  - 2
DP  - 2013 Jan 15
TI  - Detection of genotoxic and non-genotoxic carcinogens in Xpc(-/-)p53(+/-) mice.
PG  - 289-97
LID - 10.1016/j.taap.2012.11.004 [doi]
LID - S0041-008X(12)00477-2 [pii]
AB  - An accurate assessment of the carcinogenic potential of chemicals and
      pharmaceutical drugs is essential to protect humans and the environment.
      Therefore, substances are extensively tested before they are marketed to the
      public. Currently, the rodent two-year bioassay is still routinely used to assess
      the carcinogenic potential of substances. However, over time it has become clear 
      that this assay yields false positive results and also has several economic and
      ethical drawbacks including the use of large numbers of animals, the long
      duration, and the high cost. The need for a suitable alternative assay is
      therefore high. Previously, we have proposed the Xpa*p53 mouse model as a very
      suitable alternative to the two-year bioassay. We now show that the Xpc*p53 mouse
      model preserves all the beneficial traits of the Xpa*p53 model for sub-chronic
      carcinogen identification and can identify both genotoxic and non-genotoxic
      carcinogens. Moreover, Xpc*p53 mice appear to be more responsive than Xpa*p53
      mice towards several genotoxic and non-genotoxic carcinogens. Furthermore,
      Xpc*p53 mice are far less sensitive than Xpa*p53 mice for the toxic activity of
      DNA damaging agents and as such clearly respond in a similar way as wild type
      mice do. These advantageous traits of the Xpc*p53 model make it a better
      alternative for in vivo carcinogen testing than Xpa*p53. This pilot study
      suggests that Xpc*p53 mice are suited for routine sub-chronic testing of both
      genotoxic and non-genotoxic carcinogens and as such represent a suitable
      alternative to possibly replace the murine life time cancer bioassay.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Melis, Joost P M
AU  - Melis JP
AD  - Laboratory for Health Protection Research, National Institute for Public Health
      and the Environment (RIVM), Bilthoven, The Netherlands.
FAU - Speksnijder, Ewoud N
AU  - Speksnijder EN
FAU - Kuiper, Raoul V
AU  - Kuiper RV
FAU - Salvatori, Daniela C F
AU  - Salvatori DC
FAU - Schaap, Mirjam M
AU  - Schaap MM
FAU - Maas, Saskia
AU  - Maas S
FAU - Robinson, Joke
AU  - Robinson J
FAU - Verhoef, Aart
AU  - Verhoef A
FAU - van Benthem, Jan
AU  - van Benthem J
FAU - Luijten, Mirjam
AU  - Luijten M
FAU - van Steeg, Harry
AU  - van Steeg H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20121112
PL  - United States
TA  - Toxicol Appl Pharmacol
JT  - Toxicology and applied pharmacology
JID - 0416575
RN  - 0 (Carcinogens)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Mutagens)
RN  - 0 (Xeroderma Pigmentosum Group A Protein)
RN  - 0 (Xpa protein, mouse)
RN  - 0 (Xpc protein, mouse)
SB  - IM
MH  - Animals
MH  - Carcinogenicity Tests/methods
MH  - Carcinogens/*toxicity
MH  - DNA Damage/drug effects
MH  - DNA-Binding Proteins/*genetics
MH  - Disease Models, Animal
MH  - Female
MH  - Genes, p53/*genetics
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Mutagenicity Tests/methods
MH  - Mutagens/*toxicity
MH  - Pilot Projects
MH  - Xeroderma Pigmentosum Group A Protein/*genetics
EDAT- 2012/11/17 06:00
MHDA- 2013/02/21 06:00
CRDT- 2012/11/17 06:00
PHST- 2012/09/26 00:00 [received]
PHST- 2012/11/02 00:00 [revised]
PHST- 2012/11/05 00:00 [accepted]
PHST- 2012/11/17 06:00 [entrez]
PHST- 2012/11/17 06:00 [pubmed]
PHST- 2013/02/21 06:00 [medline]
AID - S0041-008X(12)00477-2 [pii]
AID - 10.1016/j.taap.2012.11.004 [doi]
PST - ppublish
SO  - Toxicol Appl Pharmacol. 2013 Jan 15;266(2):289-97. doi:
      10.1016/j.taap.2012.11.004. Epub 2012 Nov 12.


PMID- 23152737
OWN - NLM
STAT- MEDLINE
DCOM- 20130318
LR  - 20211021
IS  - 1866-0452 (Electronic)
IS  - 1866-0452 (Linking)
VI  - 109
IP  - 33-34
DP  - 2012 Aug
TI  - The deactivation of implantable cardioverter-defibrillators: medical, ethical,
      practical, and legal considerations.
PG  - 535-41
LID - 10.3238/arztebl.2012.0535 [doi]
AB  - BACKGROUND: Implantable cardioverter-defibrillators (ICDs) cannot prevent death
      from progressive heart failure or non-cardiac disease. Patients with ICDs may
      receive defibrillation therapy from their devices in the last days of their
      lives, when such therapy does not accord with the goal of palliative treatment,
      but rather lowers these patients' quality of life and compromises their dignity. 
      METHODS: We present a case report and a selective review of pertinent literature 
      retrieved by a PubMed search, including two up-to-date consensus documents.
      RESULTS: One-third to two-thirds of all ICD patients receive defibrillation
      therapy in the final days of their lives. Patients and their physicians rarely
      discuss deactivating the ICD. The ethical aspects of such decisions need to be
      considered. As a practical matter, it is possible to deactivate certain types of 
      electrotherapy selectively, while leaving others active. There are logistical
      considerations as well. CONCLUSION: Automatic defibrillation therapy in a
      terminally ill patient with an ICD is painful and distressing, serves no medical 
      purpose, and should be avoided. This issue should be discussed with ICD patients 
      and their families. Institutions caring for terminally ill patients, as well as
      cardiology units where ICD patients are treated, should develop ethically and
      legally well-founded protocols for dealing with the question of ICD deactivation.
FAU - Carlsson, Jorg
AU  - Carlsson J
AD  - Department of Internal Medicine, Section of Cardiology, Kalmar County Hospital,
      Kalmar, Sweden. jorg.carlsson@ltkalmar.se
FAU - Paul, Norbert W
AU  - Paul NW
FAU - Dann, Matthias
AU  - Dann M
FAU - Neuzner, Jorg
AU  - Neuzner J
FAU - Pfeiffer, Dietrich
AU  - Pfeiffer D
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20120820
PL  - Germany
TA  - Dtsch Arztebl Int
JT  - Deutsches Arzteblatt international
JID - 101475967
SB  - IM
MH  - Aged
MH  - *Attitude of Health Personnel
MH  - Defibrillators, Implantable/*ethics
MH  - Fatal Outcome
MH  - Germany
MH  - Heart Failure/prevention & control
MH  - Humans
MH  - Male
MH  - Terminal Care/*ethics/*legislation & jurisprudence
MH  - Terminally Ill/*legislation & jurisprudence
MH  - Withholding Treatment/*ethics/*legislation & jurisprudence
PMC - PMC3444849
EDAT- 2012/11/16 06:00
MHDA- 2013/03/19 06:00
CRDT- 2012/11/16 06:00
PHST- 2011/07/11 00:00 [received]
PHST- 2012/01/24 00:00 [accepted]
PHST- 2012/11/16 06:00 [entrez]
PHST- 2012/11/16 06:00 [pubmed]
PHST- 2013/03/19 06:00 [medline]
AID - 10.3238/arztebl.2012.0535 [doi]
PST - ppublish
SO  - Dtsch Arztebl Int. 2012 Aug;109(33-34):535-41. doi: 10.3238/arztebl.2012.0535.
      Epub 2012 Aug 20.


PMID- 23152703
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121119
LR  - 20211021
IS  - 1179-1322 (Electronic)
IS  - 1179-1322 (Linking)
VI  - 4
DP  - 2012
TI  - Breast imaging reports for malignant lesions: are we maintaining recommended
      BI-RADS((R)) lexicon standards?
PG  - 379-82
LID - 10.2147/CMAR.S36879 [doi]
AB  - BACKGROUND: The purpose of this study was to evaluate mammography reports for
      diagnosed breast cancer cases in major government and private centers in Karachi,
      Pakistan, with respect to concordance with the Breast Imaging Reports And Data
      System (BI-RADS((R))) lexicon. METHODS: A prospective, descriptive, multicenter
      study was conducted in the radiology sections of the Aga Khan University
      Hospital, Pakistan Naval Station Shifa Hospital, Advanced Radiology Clinic,
      Karachi Institute of Radiotherapy and Nuclear Medicine, and Civil Hospital
      Karachi between May and October 2010 after approval from the ethical review
      committee of Aga Khan University. Mammograms reported as BI-RADS category 4 and 5
      were included in the study. Mammograms reported as BI-RADS category 0, 1, 2 and 3
      were excluded. Fifty reports were collected from each center. Data were collected
      about the clinical indication, breast density, location and description of the
      lesion, calcification, and comments on axillary lymph nodes. This description was
      compared with the BI-RADS lexicon. RESULTS: The mean age of the patients was 50
      +/- 12 years. The clinical indication, breast parenchymal density, lesion
      location, and presence of calcification were better described by the private
      centers, while description of lymph node status was better stated by the
      government centers. This difference was statistically significant, except for
      lesion description. The description of masses by the two reporting groups was
      comparable. CONCLUSION: Mammographic reporting of malignant breast lesions in the
      private sector is more in line with the BI-RADS lexicon, as compared with
      government sector hospitals in Karachi, Pakistan. Lymph node documentation was
      better in government sector reports.
FAU - Masroor, Imrana
AU  - Masroor I
AD  - Radiology Department, Aga Khan University Hospital, Karachi, Pakistan.
FAU - Azeemuddin, Muhammad
AU  - Azeemuddin M
FAU - Sakhawat, Saima
AU  - Sakhawat S
FAU - Beg, Madiha
AU  - Beg M
FAU - Sohail, Saba
AU  - Sohail S
FAU - Ahmed, Rashid
AU  - Ahmed R
FAU - Irfan-Ul-Haq
AU  - Irfan-Ul-Haq
FAU - Mehboob, Javed
AU  - Mehboob J
LA  - eng
PT  - Journal Article
DEP - 20121107
PL  - New Zealand
TA  - Cancer Manag Res
JT  - Cancer management and research
JID - 101512700
PMC - PMC3496367
OTO - NOTNLM
OT  - BI-RADS(R)
OT  - breast cancer
OT  - mammography
OT  - private sector
OT  - public sector
EDAT- 2012/11/16 06:00
MHDA- 2012/11/16 06:01
CRDT- 2012/11/16 06:00
PHST- 2012/11/16 06:00 [entrez]
PHST- 2012/11/16 06:00 [pubmed]
PHST- 2012/11/16 06:01 [medline]
AID - 10.2147/CMAR.S36879 [doi]
AID - cmar-4-379 [pii]
PST - ppublish
SO  - Cancer Manag Res. 2012;4:379-82. doi: 10.2147/CMAR.S36879. Epub 2012 Nov 7.


PMID- 23152687
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121119
LR  - 20211021
IS  - 1178-2390 (Electronic)
IS  - 1178-2390 (Linking)
VI  - 5
DP  - 2012
TI  - Adolescent boys with asthma - a pilot study on embodied gendered habits.
PG  - 289-97
LID - 10.2147/JMDH.S37517 [doi]
AB  - PURPOSE: Asthma is a common chronic disease with gender differences in terms of
      severity and quality of life. This study aimed to understand the gendered
      practices of male asthmatic adolescents in terms of living with and managing
      their chronic disease. The study applied a sociological perspective to identify
      the gender-related practices of participants and their possible consequences for 
      health and disease. PATIENTS AND METHODS: The study used a combined
      ethnomethodology and grounded theory design, which was interpreted using
      Bourdieu's theory of practice. We aimed to discover how participants interpreted 
      their social worlds to create a sense of meaning in their everyday lives. The
      study was based on multistage focus group interviews with five adolescent
      participants at a specialist center for asthmatic children and youths. We took
      necessary precautions to protect the participants, according to the principles of
      the Declaration of Helsinki. The study protocol was approved by the Regional
      Committee for Medical Research Ethics and the hospital's research department.
      RESULTS: The core concept for asthmatic male adolescents was being men. They were
      focused on being nonasthmatic, and exhibited ambivalence towards the principles
      of the health services. Physical activity supported their aim of being men and
      being nonasthmatic, as well as supported their treatment goals. Being fearless,
      unconcerned, "cool," and dependent also supported the aim of being men and being 
      nonasthmatic, but not the health service principle of regular medication.
      Occasionally, the participants were asthmatic when they were not able to or
      gained no advantages from being nonasthmatic. Their practice of being men
      independently of being asthmatic emphasized their deeply gendered habits.
      CONCLUSION: Understanding gender differences in living with and managing asthma
      is important for health workers. Knowledge of embodied gendered habits and their 
      reproduction in social interactions and clinical work should be exploited as a
      resource during the supervision of asthmatic adolescent boys.
FAU - Westergren, Thomas
AU  - Westergren T
AD  - Faculty of Health and Sport Science, Department of Health and Nursing Science,
      University of Agder, Grimstad, Norway.
FAU - Lilleaas, Ulla-Britt
AU  - Lilleaas UB
LA  - eng
PT  - Journal Article
DEP - 20121105
PL  - New Zealand
TA  - J Multidiscip Healthc
JT  - Journal of multidisciplinary healthcare
JID - 101512691
PMC - PMC3496521
OTO - NOTNLM
OT  - doing gender
OT  - ethnomethodology
OT  - focus group
OT  - grounded theory
OT  - men's health
OT  - qualitative approach
EDAT- 2012/11/16 06:00
MHDA- 2012/11/16 06:01
CRDT- 2012/11/16 06:00
PHST- 2012/11/16 06:00 [entrez]
PHST- 2012/11/16 06:00 [pubmed]
PHST- 2012/11/16 06:01 [medline]
AID - 10.2147/JMDH.S37517 [doi]
AID - jmdh-5-289 [pii]
PST - ppublish
SO  - J Multidiscip Healthc. 2012;5:289-97. doi: 10.2147/JMDH.S37517. Epub 2012 Nov 5.


PMID- 23152427
OWN - NLM
STAT- MEDLINE
DCOM- 20130408
LR  - 20151119
IS  - 1548-923X (Electronic)
IS  - 1548-923X (Linking)
VI  - 9
DP  - 2012 Nov 10
TI  - Toward the development of a nursing practice for older persons with acute
      confusional state (ACS).
LID - 10.1515/1548-923X.2454 [doi]
LID - /j/ijnes.2012.9.issue-1/1548-923X.2454/1548-923X.2454.xml [pii]
AB  - Surgery unit nurses often deal with older people in an acute confusional state
      (ACS). To care for them, nurses must resort to different patterns of knowing,
      including empirical, esthetic, ethical, personal and emancipatory. According to
      Chinn and Kramer (2008), it is by consciously and deliberately asking themselves 
      critical questions about specific clinical situations that nurses can enhance
      their knowledge and improve practice. In this regard, narrative pedagogy
      developed by Diekelmann (2001), which encourages sharing lived experiences and
      seeking other possibilities for the future, seems a well suited approach. This
      article presents the theoretical bases of narrative pedagogy and the grounds for 
      an intervention inspired by this approach and intended for nurses who must care
      for hospitalized older people in an ACS. This innovative pedagogical
      intervention, which encourages nurses to participate actively in their learning, 
      is consistent with recent empirical works on continuing education of health
      professionals.
FAU - Belanger, Louise
AU  - Belanger L
AD  - Universite du Quebec en Outaouais, Gatineau. louise.belanger@uqo.ca
FAU - Ducharme, Francine
AU  - Ducharme F
LA  - eng
PT  - Journal Article
DEP - 20121110
PL  - Germany
TA  - Int J Nurs Educ Scholarsh
JT  - International journal of nursing education scholarship
JID - 101214977
SB  - IM
MH  - Acute Disease
MH  - Aged
MH  - *Clinical Competence
MH  - Confusion/*nursing
MH  - Evidence-Based Nursing
MH  - Helping Behavior
MH  - Humans
MH  - Middle Aged
MH  - Models, Nursing
MH  - *Nurse's Role
MH  - *Nurse-Patient Relations
MH  - Nursing Methodology Research
MH  - Nursing Staff, Hospital/*organization & administration
MH  - Practice Patterns, Nurses'/*organization & administration
EDAT- 2012/11/16 06:00
MHDA- 2013/04/09 06:00
CRDT- 2012/11/16 06:00
PHST- 2012/11/16 06:00 [entrez]
PHST- 2012/11/16 06:00 [pubmed]
PHST- 2013/04/09 06:00 [medline]
AID - 10.1515/1548-923X.2454 [doi]
AID - /j/ijnes.2012.9.issue-1/1548-923X.2454/1548-923X.2454.xml [pii]
PST - epublish
SO  - Int J Nurs Educ Scholarsh. 2012 Nov 10;9. pii:
      /j/ijnes.2012.9.issue-1/1548-923X.2454/1548-923X.2454.xml. doi:
      10.1515/1548-923X.2454.


PMID- 23151830
OWN - NLM
STAT- MEDLINE
DCOM- 20130405
LR  - 20220321
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 266
IP  - 2
DP  - 2013 Feb
TI  - Head and neck squamous cell carcinoma: diagnostic performance of
      diffusion-weighted MR imaging for the prediction of treatment response.
PG  - 531-8
LID - 10.1148/radiol.12120167 [doi]
AB  - PURPOSE: To determine the diagnostic performance of diffusion-weighted (DW)
      imaging for the prediction of treatment failure in primary head and neck squamous
      cell carcinoma (HNSCC). MATERIALS AND METHODS: The study was approved by the
      local institutional ethics committee and conducted with informed written consent 
      in patients with primary HNSCC treated with radiation therapy and chemotherapy.
      DW imaging of the primary tumor was performed before treatment in 37 patients and
      was repeated within 2 weeks of treatment in 30 patients. Histograms of apparent
      diffusion coefficients (ADCs) were analyzed, and mean ADC, kurtosis, skewness,
      and their respective percentage change were correlated for local failure and
      local control at 2 years by using the Student t test. Univariate and multivariate
      analyses of the ADC parameters, T stage, and tumor volume were performed by using
      logistic regression for prediction of local failure. RESULTS: Local failure
      occurred in 16 of 37 (43%) patients and local control occurred in 21 of 37 (57%) 
      patients. Pretreatment ADC parameters showed no correlation with local failure.
      There was significant intratreatment increase in mean ADC and a decrease in
      skewness and kurtosis (P < .001, P < .001, P = .024, respectively) for the whole 
      group of patients when compared with those before treatment. During treatment,
      primary tumors showed a significantly lower increase in percentage change of mean
      ADC, higher skewness, and higher kurtosis for local failure than for local
      control (P = .016, .015, and .040, respectively). These ADC parameters also were 
      significant for predicting local failure with use of univariate but not
      multivariate analysis. CONCLUSION: Early intratreatment DW imaging has the
      potential to allow prediction of treatment response at the primary site in
      patients with HNSCC.
FAU - King, Ann D
AU  - King AD
AD  - Department of Imaging and Interventional Radiology, Faculty of Medicine, The
      Chinese University of Hong Kong, Prince of Wales Hospital, 30-32 Ngai Shing
      Street, Shatin, New Territories, Hong Kong SAR, China. king2015@cuhk.edu.hk
FAU - Chow, Kwok-Keung
AU  - Chow KK
FAU - Yu, Kwok-Hung
AU  - Yu KH
FAU - Mo, Frankie Kwok Fai
AU  - Mo FK
FAU - Yeung, David K W
AU  - Yeung DK
FAU - Yuan, Jing
AU  - Yuan J
FAU - Bhatia, Kunwar S
AU  - Bhatia KS
FAU - Vlantis, Alexander C
AU  - Vlantis AC
FAU - Ahuja, Anil T
AU  - Ahuja AT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121114
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Aged
MH  - Carcinoma, Squamous Cell/*diagnosis/*therapy
MH  - Combined Modality Therapy
MH  - Diffusion Magnetic Resonance Imaging/*methods
MH  - Female
MH  - Head and Neck Neoplasms/*diagnosis/*therapy
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Predictive Value of Tests
MH  - Proportional Hazards Models
MH  - ROC Curve
MH  - Sensitivity and Specificity
MH  - Treatment Failure
MH  - Treatment Outcome
EDAT- 2012/11/16 06:00
MHDA- 2013/04/06 06:00
CRDT- 2012/11/16 06:00
PHST- 2012/11/16 06:00 [entrez]
PHST- 2012/11/16 06:00 [pubmed]
PHST- 2013/04/06 06:00 [medline]
AID - radiol.12120167 [pii]
AID - 10.1148/radiol.12120167 [doi]
PST - ppublish
SO  - Radiology. 2013 Feb;266(2):531-8. doi: 10.1148/radiol.12120167. Epub 2012 Nov 14.


PMID- 23151829
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20220318
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 266
IP  - 1
DP  - 2013 Jan
TI  - Assessment of primary colorectal cancer heterogeneity by using whole-tumor
      texture analysis: contrast-enhanced CT texture as a biomarker of 5-year survival.
PG  - 177-84
LID - 10.1148/radiol.12120254 [doi]
AB  - PURPOSE: To determine if computed tomographic (CT) texture features of primary
      colorectal cancer are related to 5-year overall survival rate. MATERIALS AND
      METHODS: Institutional review board waiver was obtained for this retrospective
      analysis. Texture features of the entire primary tumor were assessed with
      contrast material-enhanced staging CT studies obtained in 57 patients as part of 
      an ethically approved study and by using proprietary software. Entropy,
      uniformity, kurtosis, skewness, and standard deviation of the pixel distribution 
      histogram were derived from CT images without filtration and with filter values
      corresponding to fine (1.0), medium (1.5, 2.0), and coarse (2.5) textures.
      Patients were followed up until death and were censored at 5 years if they were
      still alive. Kaplan-Meier analysis was performed to determine the relationship,
      if any, between CT texture and 5-year overall survival rate. The Cox proportional
      hazards model was used to assess independence of texture parameters from stage.
      RESULTS: Follow-up data were available for 55 of 57 patients. There were eight
      stage I, 19 stage II, 17 stage III, and 11 stage IV cancers. Fine-texture feature
      Kaplan-Meier survival plots for entropy, uniformity, kurtosis, skewness, and
      standard deviation of the pixel distribution histogram were significantly
      different for tumors above and below each respective threshold receiver operating
      characteristic (ROC) curve optimal cutoff value (P = .001, P = .018, P = .032, P 
      = .008, and P = .001, respectively), with poorer prognosis for ROC optimal values
      (a) less than 7.89 for entropy, (b) at least 0.01 for uniformity, (c) less than
      2.48 for kurtosis, (d) at least -0.38 for skewness, and (e) less than 61.83 for
      standard deviation. Multivariate Cox proportional hazards regression analysis
      showed that each parameter was independent from the stage predictor of overall
      survival rate (P = .001, P = .009, P = .006, P = .02, and P = .001,
      respectively). CONCLUSION: Fine-texture features are associated with poorer
      5-year overall survival rate in patients with primary colorectal cancer.
      SUPPLEMENTAL MATERIAL:
      http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.12120254/-/DC1.
CI  - RSNA, 2012
FAU - Ng, Francesca
AU  - Ng F
AD  - Paul Strickland Scanner Centre, Mount Vernon Hospital, Northwood, England.
FAU - Ganeshan, Balaji
AU  - Ganeshan B
FAU - Kozarski, Robert
AU  - Kozarski R
FAU - Miles, Kenneth A
AU  - Miles KA
FAU - Goh, Vicky
AU  - Goh V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121114
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Colorectal Neoplasms/*diagnostic imaging/*mortality
MH  - Disease-Free Survival
MH  - England/epidemiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Prognosis
MH  - Reproducibility of Results
MH  - Risk Factors
MH  - Sensitivity and Specificity
MH  - Survival Analysis
MH  - Survival Rate
MH  - Tomography, X-Ray Computed/*statistics & numerical data
EDAT- 2012/11/16 06:00
MHDA- 2013/02/13 06:00
CRDT- 2012/11/16 06:00
PHST- 2012/11/16 06:00 [entrez]
PHST- 2012/11/16 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
AID - radiol.12120254 [pii]
AID - 10.1148/radiol.12120254 [doi]
PST - ppublish
SO  - Radiology. 2013 Jan;266(1):177-84. doi: 10.1148/radiol.12120254. Epub 2012 Nov
      14.


PMID- 23151827
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20220317
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 266
IP  - 1
DP  - 2013 Jan
TI  - Mild cognitive impairment: cerebrospinal fluid tau biomarker pathologic levels
      and longitudinal changes in white matter integrity.
PG  - 295-303
LID - 10.1148/radiol.12120319 [doi]
AB  - PURPOSE: To evaluate the relationship between (a) pathologic levels of
      cerebrospinal fluid (CSF) total tau as an index of the intensity of ongoing
      neuronal degeneration and (b) longitudinal changes in white matter (WM) integrity
      in patients with mild cognitive impairment (MCI). MATERIALS AND METHODS:
      Participants gave written informed consent, and the Norwegian committee for
      medical research ethics approved the study. Thirty patients with MCI and
      nonpathologic CSF total tau levels, nine patients with MCI and pathologic CSF
      total tau levels, and 16 age-matched healthy control subjects underwent
      diffusion-tensor imaging at baseline and after a mean follow-up of 2.6 years +/- 
      0.54 (standard deviation), with range of 1.58-3.98 years. The effect of diagnosis
      (MCI vs no MCI) at baseline and CSF tau levels at fractional anisotropy (FA),
      mean diffusivity, radial diffusivity (D(R)), and axial diffusivity were tested
      with tract-based spatial statistics. Differences in WM integrity at baseline and 
      follow-up and change over time were compared among patients with pathologic CSF
      total tau levels (MCI high tau), patients with normal CSF total tau levels (MCI
      low tau), and healthy control subjects. Linear mixed-model between-group
      within-subject analyses were conducted to examine differences in rate of change
      over time in FA and D(R). RESULTS: Longitudinal analysis of regional WM change
      revealed significant decrease in FA (P = .038) and increase in D(R) (P = .018) in
      the MCI high-tau group relative to control subjects. For D(R), the changes were
      regionally specific to the right cingulum and the right superior and inferior
      longitudinal fasciculi. CONCLUSION: Reduction in WM integrity was greater in
      patients with MCI who had the most intense neuronal degeneration as indexed by
      using CSF total tau, suggesting that these patients might represent a subgroup of
      MCI with more intense WM degeneration who are possibly at greater risk of
      developing Alzheimer disease.
CI  - RSNA, 2012
FAU - Amlien, Inge K
AU  - Amlien IK
AD  - Center for the Study of Human Cognition, Department of Psychology, University of 
      Oslo, Pb. 1094 Blindern, 0317 Oslo, Norway. inge.amlien@psykologi.uio.no
FAU - Fjell, Anders M
AU  - Fjell AM
FAU - Walhovd, Kristine B
AU  - Walhovd KB
FAU - Selnes, Per
AU  - Selnes P
FAU - Stenset, Vidar
AU  - Stenset V
FAU - Grambaite, Ramune
AU  - Grambaite R
FAU - Bjornerud, Atle
AU  - Bjornerud A
FAU - Due-Tonnessen, Paulina
AU  - Due-Tonnessen P
FAU - Skinningsrud, Anders
AU  - Skinningsrud A
FAU - Gjerstad, Leif
AU  - Gjerstad L
FAU - Reinvang, Ivar
AU  - Reinvang I
FAU - Fladby, Tormod
AU  - Fladby T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121114
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Biomarkers)
RN  - 0 (tau Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/cerebrospinal fluid
MH  - Cognitive Dysfunction/*cerebrospinal fluid/*pathology
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers, Myelinated/*pathology
MH  - Neurons/*pathology
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Statistics as Topic
MH  - tau Proteins/*cerebrospinal fluid
EDAT- 2012/11/16 06:00
MHDA- 2013/02/13 06:00
CRDT- 2012/11/16 06:00
PHST- 2012/11/16 06:00 [entrez]
PHST- 2012/11/16 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
AID - radiol.12120319 [pii]
AID - 10.1148/radiol.12120319 [doi]
PST - ppublish
SO  - Radiology. 2013 Jan;266(1):295-303. doi: 10.1148/radiol.12120319. Epub 2012 Nov
      14.


PMID- 23151824
OWN - NLM
STAT- MEDLINE
DCOM- 20130405
LR  - 20151119
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 266
IP  - 2
DP  - 2013 Feb
TI  - Nonselective transarterial chemoperfusion: a palliative treatment for malignant
      pleural mesothelioma.
PG  - 649-56
LID - 10.1148/radiol.12111858 [doi]
AB  - PURPOSE: To evaluate tumor response by means of volumetric assessment, survival, 
      and changes in patient symptoms after the treatment of unresectable and/or
      recurrent pleural mesothelioma by using regional nonselective transarterial
      chemoperfusion as a palliative treatment option. MATERIALS AND METHODS: This
      retrospective study was approved by the hospital ethical committee, and all
      patients signed an informed consent prior to treatment. Thirty-nine patients
      (mean age, 64.0 years; 10 women and 29 men) with unresectable pleural
      mesothelioma were treated with repetitive transarterial chemoperfusion between
      March 2007 and March 2010, with a mean of 2.9 sessions per patient at 4-week
      intervals. Transarterial chemoperfusion was performed by using mitomycin C,
      cisplatin, and gemcitabine. Computed tomography findings and patient symptoms
      were evaluated. Tumor response was evaluated by using Response Evaluation
      Criteria in Solid Tumors guidelines, and survival was assessed with the
      Kaplan-Meier method. The change in volume for the partial-response group was
      tested by using the Wilcoxon signed-rank test. RESULTS: In 36% of treated tumors 
      (14 of 39), partial response was achieved, and tumor volume decreased from a mean
      value +/- standard deviation of 839.6 mL +/- 590.3 (range, 3.9-1972.2 mL) to 137 
      mL +/- 399.8 (range, 0.88-1131.4; P = .00012). In 49% of tumors (19 of 39),
      stable disease was noted. In 15% of tumors (six of 39), progressive disease was
      seen. Mean specific growth rate of the tumor was 0.00158% per day. The mean
      survival time was 14.2 months (range, 2.1-33.1 months) from the start of
      treatment. For patients with tumors that responded to treatment, mean survival
      time was 15 months (range, 4.5-33.1 months). Mean time to disease progression was
      2.6 months for all tumors, 1.5 months for stable disease, and 1.3 months for
      progressive disease. CONCLUSION: Transarterial chemoperfusion may have the
      potential to yield positive results and response in the treatment of recurrent
      and/or unresectable pleural mesothelioma. (c) RSNA, 2012.
FAU - Vogl, Thomas J
AU  - Vogl TJ
AD  - Institute for Diagnostic and Interventional Radiology, Johann Wolfgang Goethe
      University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.
      T.Vogl@em.uni-frankfurt.de
FAU - Lindemayr, Sebastian
AU  - Lindemayr S
FAU - Naguib, Nagy N N
AU  - Naguib NN
FAU - Gurung, Jessen
AU  - Gurung J
FAU - Nour-Eldin, Nour-Eldin A
AU  - Nour-Eldin NE
FAU - Zangos, Stephan
AU  - Zangos S
FAU - Mbalisike, Emmanuel C
AU  - Mbalisike EC
LA  - eng
PT  - Journal Article
DEP - 20121114
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0W860991D6 (Deoxycytidine)
RN  - 50SG953SK6 (Mitomycin)
RN  - B76N6SBZ8R (gemcitabine)
RN  - Q20Q21Q62J (Cisplatin)
SB  - IM
MH  - Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
MH  - Cisplatin/administration & dosage
MH  - Deoxycytidine/administration & dosage/analogs & derivatives
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Infusions, Intra-Arterial
MH  - Male
MH  - Mesothelioma/*drug therapy
MH  - Middle Aged
MH  - Mitomycin/administration & dosage
MH  - Pain Measurement
MH  - *Palliative Care
MH  - Pleural Neoplasms/*drug therapy
MH  - Retrospective Studies
MH  - Statistics, Nonparametric
MH  - Surveys and Questionnaires
MH  - Tomography, X-Ray Computed
MH  - Treatment Outcome
EDAT- 2012/11/16 06:00
MHDA- 2013/04/06 06:00
CRDT- 2012/11/16 06:00
PHST- 2012/11/16 06:00 [entrez]
PHST- 2012/11/16 06:00 [pubmed]
PHST- 2013/04/06 06:00 [medline]
AID - radiol.12111858 [pii]
AID - 10.1148/radiol.12111858 [doi]
PST - ppublish
SO  - Radiology. 2013 Feb;266(2):649-56. doi: 10.1148/radiol.12111858. Epub 2012 Nov
      14.


PMID- 23151823
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20220310
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 266
IP  - 1
DP  - 2013 Jan
TI  - Dynamic contrast-enhanced MR imaging of carotid atherosclerotic plaque: model
      selection, reproducibility, and validation.
PG  - 271-9
LID - 10.1148/radiol.12120499 [doi]
AB  - PURPOSE: To compare four known pharmacokinetic models for their ability to
      describe dynamic contrast material-enhanced magnetic resonance (MR) imaging of
      carotid atherosclerotic plaques, to determine reproducibility, and to validate
      the results with histologic findings. MATERIALS AND METHODS: The study was
      approved by the institutional medical ethics committee. Written informed consent 
      was obtained from all patients. Forty-five patients with 30%-99% carotid stenosis
      underwent dynamic contrast-enhanced MR imaging. Plaque enhancement was measured
      at 16 time points at approximately 25-second image intervals by using a
      gadolinium-based contrast material. Pharmacokinetic parameters (volume transfer
      constant, K(trans); extracellular extravascular volume fraction, v(e); and blood 
      plasma fraction, v(p)) were determined by fitting a two-compartment model to
      plaque and blood gadolinium concentration curves. The relative fit errors and
      parameter uncertainties were determined to find the most suitable model. Sixteen 
      patients underwent imaging twice to determine reproducibility. Carotid
      endarterectomy specimens from 16 patients who were scheduled for surgery were
      collected for histologic validation. Parameter uncertainties were compared with
      the Wilcoxon signed rank test. Reproducibility was assessed by using the
      coefficient of variation. Correlation with histologic findings was evaluated with
      the Pearson correlation coefficient. RESULTS: The mean relative fit uncertainty
      (+/-standard error) for K(trans) was 10% +/- 1 with the Patlak model, which was
      significantly lower than that with the Tofts (20% +/- 1), extended Tofts (33% +/-
      3), and extended graphical (29% +/- 3) models (P < .001). The relative
      uncertainty for v(p) was 20% +/- 2 with the Patlak model and was significantly
      higher with the extended Tofts (46% +/- 9) and extended graphical (35% +/- 5)
      models (P < .001). The reproducibility (coefficient of variation) for the Patlak 
      model was 16% for K(trans) and 26% for v(p). Significant positive correlations
      were found between K(trans) and the endothelial microvessel content determined on
      histologic slices (Pearson rho = 0.72, P = .005). CONCLUSION: The Patlak model is
      most suited for describing carotid plaque enhancement. Correlation with
      histologic findings validated K(trans) as an indicator of plaque
      microvasculature, and the reproducibility of K(trans) was good.
CI  - RSNA, 2012
FAU - Gaens, Michaela E
AU  - Gaens ME
AD  - Department of Radiology, Cardiovascular Research Institute Maastricht, Maastricht
      University Medical Center, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands.
FAU - Backes, Walter H
AU  - Backes WH
FAU - Rozel, Stefan
AU  - Rozel S
FAU - Lipperts, Matthijs
AU  - Lipperts M
FAU - Sanders, Stefan N
AU  - Sanders SN
FAU - Jaspers, Karolien
AU  - Jaspers K
FAU - Cleutjens, Jacques P M
AU  - Cleutjens JP
FAU - Sluimer, Judith C
AU  - Sluimer JC
FAU - Heeneman, Sylvia
AU  - Heeneman S
FAU - Daemen, Mat J A P
AU  - Daemen MJ
FAU - Welten, Rob J T J
AU  - Welten RJ
FAU - Daemen, Jan-Willem H
AU  - Daemen JW
FAU - Wildberger, Joachim E
AU  - Wildberger JE
FAU - Kwee, Robert M
AU  - Kwee RM
FAU - Kooi, M Eline
AU  - Kooi ME
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20121114
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Aged
MH  - Algorithms
MH  - Carotid Artery Diseases/*metabolism/*pathology
MH  - Computer Simulation
MH  - Contrast Media/pharmacokinetics
MH  - Female
MH  - Gadolinium DTPA/*pharmacokinetics
MH  - Humans
MH  - Image Enhancement/methods
MH  - Image Interpretation, Computer-Assisted/*methods
MH  - Magnetic Resonance Angiography/*methods
MH  - Male
MH  - Metabolic Clearance Rate
MH  - *Models, Biological
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
EDAT- 2012/11/16 06:00
MHDA- 2013/02/13 06:00
CRDT- 2012/11/16 06:00
PHST- 2012/11/16 06:00 [entrez]
PHST- 2012/11/16 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
AID - radiol.12120499 [pii]
AID - 10.1148/radiol.12120499 [doi]
PST - ppublish
SO  - Radiology. 2013 Jan;266(1):271-9. doi: 10.1148/radiol.12120499. Epub 2012 Nov 14.


PMID- 23151421
OWN - NLM
STAT- MEDLINE
DCOM- 20130402
LR  - 20180126
IS  - 1471-6771 (Electronic)
IS  - 0007-0912 (Linking)
VI  - 110
IP  - 3
DP  - 2013 Mar
TI  - Combined paravertebral and intrathecal vs thoracic epidural analgesia for
      post-thoracotomy pain relief.
PG  - 443-9
LID - 10.1093/bja/aes394 [doi]
AB  - BACKGROUND: Although thoracic epidural analgesia (TEA) is considered the gold
      standard for post-thoracotomy pain relief, thoracic paravertebral block (PVB) and
      intrathecal opioid (ITO) administration have also been shown to be efficacious.
      We hypothesized that the combination of PVB and ITO provides analgesia comparable
      with that of TEA. METHODS: After local ethics committee approval, 84 consecutive 
      patients undergoing open thoracic procedures were randomized to the TEA
      (ropivacaine 0.2%+sufentanil) or the PVB (ropivacaine 0.5%)+ITO
      (sufentanil+morphine) group. The primary endpoints were pain intensities at rest 
      and during coughing/movement at 1, 2, 4, 8, 12, 24, 48, and 72 h after operation 
      assessed by visual analogue scale (VAS) score. Data were analysed by multivariate
      analysis (anova; P<0.05). RESULTS: Patient and surgical characteristics were
      comparable between the groups. The mean and maximal VAS scores were lower in the 
      TEA (n=43) than in the PVB+ITO group (n=37) at several time points at rest
      (P<0.026) and during coughing/movement (P<0.021). However, in the PVB+ITO group, 
      the mean VAS scores never exceeded 1.9 and 3.5 at rest and during
      coughing/movement, respectively; and the maximal differences between the groups
      (TEA vs PVB+ITO) in the maximal VAS scores were only 1.2 (3.4 vs 4.6) at rest,
      and 1.3 (4.4 vs 5.7) during coughing/movement. CONCLUSIONS: Although VAS scores
      were statistically lower in the TEA compared with the PVB+ITO group at some
      observation points, the differences were small and of questionable clinical
      relevance. Thus, combined PVB and ITO can be considered a satisfactory
      alternative to TEA for post-thoracotomy pain relief. ClinicalTrials.gov number.
      NCT00493909.
FAU - Dango, S
AU  - Dango S
AD  - Department of Thoracic Surgery, University Medical Center, Hugstetter Strasse 55,
      D-79106 Freiburg, Germany.
FAU - Harris, S
AU  - Harris S
FAU - Offner, K
AU  - Offner K
FAU - Hennings, E
AU  - Hennings E
FAU - Priebe, H-J
AU  - Priebe HJ
FAU - Buerkle, H
AU  - Buerkle H
FAU - Passlick, B
AU  - Passlick B
FAU - Loop, T
AU  - Loop T
LA  - eng
SI  - ClinicalTrials.gov/NCT00493909
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20121114
PL  - England
TA  - Br J Anaesth
JT  - British journal of anaesthesia
JID - 0372541
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Anesthetics, Local)
RN  - 0 (Drug Combinations)
RN  - 76I7G6D29C (Morphine)
RN  - AFE2YW0IIZ (Sufentanil)
SB  - IM
CIN - Br J Anaesth. 2013 Sep;111(3):513-4. PMID: 23946365
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Analgesics, Opioid/administration & dosage/therapeutic use
MH  - Anesthesia, Epidural/*methods
MH  - Anesthetics, Local/administration & dosage/therapeutic use
MH  - Drug Combinations
MH  - Female
MH  - Humans
MH  - Injections, Spinal
MH  - Male
MH  - Middle Aged
MH  - Morphine/administration & dosage/therapeutic use
MH  - Pain Measurement
MH  - Pain, Postoperative/*drug therapy
MH  - Postoperative Care
MH  - Sufentanil/administration & dosage/therapeutic use
MH  - Thoracic Vertebrae
MH  - Thoracotomy/*adverse effects
MH  - Treatment Outcome
EDAT- 2012/11/16 06:00
MHDA- 2013/04/03 06:00
CRDT- 2012/11/16 06:00
PHST- 2012/11/16 06:00 [entrez]
PHST- 2012/11/16 06:00 [pubmed]
PHST- 2013/04/03 06:00 [medline]
AID - S0007-0912(17)32772-1 [pii]
AID - 10.1093/bja/aes394 [doi]
PST - ppublish
SO  - Br J Anaesth. 2013 Mar;110(3):443-9. doi: 10.1093/bja/aes394. Epub 2012 Nov 14.


PMID- 23151395
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130207
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 6
DP  - 2012
TI  - Efficacy of multimodal, systematic non-surgical treatment of knee osteoarthritis 
      for patients not eligible for a total knee replacement: a study protocol of a
      randomised controlled trial.
LID - 10.1136/bmjopen-2012-002168 [doi]
LID - e002168 [pii]
AB  - INTRODUCTION: It is recommended that non-operative treatment of knee
      osteoarthritis (KOA) should be individually tailored and include multiple
      treatment modalities. Despite these recommendations, no one has yet investigated 
      the efficacy of combining several non-surgical treatment modalities in a
      randomised controlled study. The purpose of this randomised controlled study is
      to examine if an optimised, combined non-surgical treatment programme results in 
      greater improvements in pain, function and quality of life in comparison with
      usual care in patients with KOA who are not eligible for total knee arthroplasty 
      (TKA). METHODS AND ANALYSIS: This study will include 100 consecutive patients
      from the North Denmark Region not eligible for TKA with radiographic KOA (K-L
      grade >/=1) and mean pain during the previous week of </=60 mm (0-100). The
      participants will be randomised to receive either a 12-week non-surgical
      treatment programme consisting of patient education, exercise, diet, insoles,
      paracetamol and/or NSAIDs or usual care (two information leaflets containing
      information on KOA and advice regarding the above non-surgical treatment). The
      primary outcome will be the change from baseline to 12 months on the self-report 
      questionnaire Knee Injury and Osteoarthritis Outcome Score (KOOS)(4) defined as
      the average score for the subscale scores for pain, symptoms, activities of daily
      living and quality of life. Secondary outcomes include the five individual KOOS
      subscale scores, pain on a 100 mm Visual Analogue Scale, EQ-5D, self-efficacy,
      pain pressure thresholds, postural control and isometric knee flexion and knee
      extension strength. ETHICS AND DISSEMINATION: This study was approved by the
      local Ethics Committee of The North Denmark Region (N-20110085) and the protocol 
      conforms to the principles of the Declaration of Helsinki. Data collection will
      be completed by April 2014. Publications will be ready for submission in the
      summer of 2014. TRIAL REGISTRATION NUMBER: This study is registered with
      http://clinicaltrials.gov (NCT01535001).
FAU - Skou, Soren Thorgaard
AU  - Skou ST
AD  - Orthopaedic Surgery Research Unit, Aalborg Hospital-Aarhus University Hospital,
      Aalborg, Denmark.
FAU - Roos, Ewa M
AU  - Roos EM
FAU - Laursen, Mogens Berg
AU  - Laursen MB
FAU - Rathleff, Michael Skovdal
AU  - Rathleff MS
FAU - Arendt-Nielsen, Lars
AU  - Arendt-Nielsen L
FAU - Simonsen, Ole
AU  - Simonsen O
FAU - Rasmussen, Sten
AU  - Rasmussen S
LA  - eng
SI  - ClinicalTrials.gov/NCT01535001
PT  - Journal Article
DEP - 20121114
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3533085
EDAT- 2012/11/16 06:00
MHDA- 2012/11/16 06:01
CRDT- 2012/11/16 06:00
PHST- 2012/11/16 06:00 [entrez]
PHST- 2012/11/16 06:00 [pubmed]
PHST- 2012/11/16 06:01 [medline]
AID - bmjopen-2012-002168 [pii]
AID - 10.1136/bmjopen-2012-002168 [doi]
PST - epublish
SO  - BMJ Open. 2012 Nov 14;2(6). pii: bmjopen-2012-002168. doi:
      10.1136/bmjopen-2012-002168. Print 2012.


PMID- 23151356
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121225
LR  - 20211021
IS  - 2041-2223 (Electronic)
IS  - 2041-2223 (Linking)
VI  - 3
IP  - 1
DP  - 2012 Nov 14
TI  - Socially responsible genetic research with descendants of the First Australians.
PG  - 22
LID - 10.1186/2041-2223-3-22 [doi]
AB  - Aboriginal Australians, one of the world's indigenous peoples now outnumbered
      through colonization, are the most under-represented in genetic research because 
      they feel that the benefits do not outweigh the social cost of involvement.
      Descendants of the First Australians have survived a period of European
      occupation during which time they were dispossessed of land, language and
      cultural identity resulting in inequities in health, education, and employment
      opportunities. Compared to Maori and Native American peoples, the ability to form
      organizations that help to control their affairs is very recent. The desire to
      control is understandably strong yet the 'gate-keeping' role of some
      organizations risks shifting the control away from smaller communities and has
      become increasingly politicized. In the past, research practices by Western
      scientists were poorly presented and have resulted in resistance to proposals
      that are perceived to have no beneficial outcomes for participants. In this age
      of advanced technological expertise in genetics, benefits to all humanity are
      clear to those carrying out research projects, yet not always to those being
      asked to participate, presenting extra challenges. Excellent guidelines for
      ethical conduct in research are available to assist researchers, prospective
      participants, and ethics committees or review boards that approve and monitor
      procedures. The essence of these guidelines are that research should be carried
      out with a spirit of integrity, respect, reciprocity, parity, recognition of
      survival and protection of social and cultural values, a need for control and
      shared responsibility. Specific Aboriginal organizations, with which researchers 
      need to work to negotiate partnerships, vary within and between Australian states
      and will always expect Aboriginal personnel to be involved. People experienced in
      the consultation process are necessary as part of a team. By working patiently
      through lengthy negotiations with Aboriginal Australians, scientists can achieve 
      valuable results, but failure to do so with respect and understanding will not
      yield hoped for outcomes. My own experience working with communities in the
      Darling River region of western New South Wales has been an enriching and
      rewarding one, with a long period of successful research lately delayed by
      increased expectation of monitoring and involvement at state level.
FAU - van Holst Pellekaan, Sheila M
AU  - van Holst Pellekaan SM
AD  - School of Biotechnology and Biomolecular Sciences D26, University of New South
      Wales, Kensington, New South Wales, 2052, Australia. s.vanholst@unsw.edu.au.
LA  - eng
PT  - Journal Article
DEP - 20121114
PL  - England
TA  - Investig Genet
JT  - Investigative genetics
JID - 101546908
PMC - PMC3528479
EDAT- 2012/11/16 06:00
MHDA- 2012/11/16 06:01
CRDT- 2012/11/16 06:00
PHST- 2012/07/03 00:00 [received]
PHST- 2012/10/30 00:00 [accepted]
PHST- 2012/11/16 06:00 [entrez]
PHST- 2012/11/16 06:00 [pubmed]
PHST- 2012/11/16 06:01 [medline]
AID - 2041-2223-3-22 [pii]
AID - 10.1186/2041-2223-3-22 [doi]
PST - epublish
SO  - Investig Genet. 2012 Nov 14;3(1):22. doi: 10.1186/2041-2223-3-22.


PMID- 23151156
OWN - NLM
STAT- MEDLINE
DCOM- 20130809
LR  - 20220129
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 13
DP  - 2012 Nov 14
TI  - Acupuncture, Counseling, and Usual care for Depression (ACUDep): study protocol
      for a randomized controlled trial.
PG  - 209
LID - 10.1186/1745-6215-13-209 [doi]
AB  - BACKGROUND: The evidence on the effect of acupuncture or counseling for
      depression is not conclusive yet is sufficient to warrant further research. Our
      aim is to conduct a full-scale RCT to determine the clinical and cost
      effectiveness of acupuncture and counseling compared to usual care alone. We will
      explore the experiences and perspectives of patients and practitioners.
      METHODS/DESIGN: Randomized controlled trial with three parallel arms: acupuncture
      plus usual care, counseling plus usual care, and usual care alone, in conjunction
      with a nested qualitative study using in-depth interviews with purposive samples 
      of trial participants. PARTICIPANTS: Patients aged over 18 years diagnosed with
      depression or mood disorder by their GP and with a score of 20 or above on the
      Beck Depression Inventory (BDI-II).Randomization: Computer randomization by York 
      Trials Unit to acupuncture, counseling, and usual care alone in proportions of
      2:2:1, respectively, with secure allocation concealment. INTERVENTIONS: Patients 
      allocated to acupuncture and counseling groups receive the offer of up to 12
      weekly sessions. Both interventions allow flexibility to address patient
      variation, yet are constrained within defined protocols. Acupuncture is based on 
      traditional Chinese medicine and counseling is non-directive within the
      humanistic tradition. OUTCOME: The PHQ-9 is the primary outcome measure,
      collected at baseline, 3, 6, 9, and 12 months. Also measured is BDI-II, SF-36
      Bodily pain subscale, and EQ-5D. Texted mood scores are collected weekly over the
      first 15 weeks. Health-related resource use is collected over 12 months.
      ANALYSIS: The sample size target was for 640 participants, calculated for an
      effect size of 0.32 on the PHQ-9 when comparing acupuncture with counseling given
      90% power, 5% significance, and 20% loss to follow-up. ANALYSIS of covariance
      will be used on an intention-to-treat basis. Thematic analysis will be used for
      qualitative data. We will compare incremental cost-effectiveness of the three
      treatment options at 12 months. DISCUSSION: Ethical approval was obtained in
      October 2009. There were six subsequent protocol amendments, the last of which
      was approved in January 2012. Recruitment of 755 participants took place over 18 
      months. Data collection will be completed by June 2012. No interim analyses have 
      been conducted. TRIAL REGISTRATION: ISRCTN63787732.
FAU - MacPherson, Hugh
AU  - MacPherson H
AD  - Department of Health Sciences, University of York, York YO10 5DD, United Kingdom.
      hugh.macpherson@york.ac.uk
FAU - Richmond, Stewart
AU  - Richmond S
FAU - Bland, J Martin
AU  - Bland JM
FAU - Lansdown, Harriet
AU  - Lansdown H
FAU - Hopton, Ann
AU  - Hopton A
FAU - Kang'ombe, Arthur
AU  - Kang'ombe A
FAU - Morley, Stephen
AU  - Morley S
FAU - Perren, Sara
AU  - Perren S
FAU - Spackman, Eldon
AU  - Spackman E
FAU - Spilsbury, Karen
AU  - Spilsbury K
FAU - Torgerson, David
AU  - Torgerson D
FAU - Watt, Ian
AU  - Watt I
LA  - eng
GR  - RP-PG-0707-10186/DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20121114
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
SB  - IM
MH  - *Acupuncture Therapy
MH  - *Clinical Protocols
MH  - *Counseling
MH  - Depression/*therapy
MH  - Humans
MH  - Outcome Assessment, Health Care
MH  - Patient Selection
MH  - Sample Size
PMC - PMC3582576
EDAT- 2012/11/16 06:00
MHDA- 2013/08/10 06:00
CRDT- 2012/11/16 06:00
PHST- 2012/04/26 00:00 [received]
PHST- 2012/09/24 00:00 [accepted]
PHST- 2012/11/16 06:00 [entrez]
PHST- 2012/11/16 06:00 [pubmed]
PHST- 2013/08/10 06:00 [medline]
AID - 1745-6215-13-209 [pii]
AID - 10.1186/1745-6215-13-209 [doi]
PST - epublish
SO  - Trials. 2012 Nov 14;13:209. doi: 10.1186/1745-6215-13-209.


PMID- 23151114
OWN - NLM
STAT- MEDLINE
DCOM- 20130826
LR  - 20130307
IS  - 1557-9034 (Electronic)
IS  - 1092-6429 (Linking)
VI  - 23
IP  - 3
DP  - 2013 Mar
TI  - Laparoscopic choledocholithotomy with rigid nephroscope.
PG  - 211-5
LID - 10.1089/lap.2012.0303 [doi]
AB  - BACKGROUND: Apart from the required expertise, a major deterrent to laparoscopic 
      common bile duct (CBD) lithotomy (LCDL) remains the relatively prohibitive cost
      of the flexible choledochoscope, and it also has a shortcoming of not being
      effective in removal of large impacted CBD stones. SUBJECTS AND METHODS: All
      patients presenting with CBD stones were treated, without exclusion, by
      laparoscopic cholecystectomy plus transdochal LCDL after relevant investigations.
      LCDL was performed using a rigid nephroscope. The CBD was closed either with
      running 3-0 polyglactin acid (Vicryl; Ethicon) sutures without a stent or around 
      a T tube in a few patients. Perioperative parameters were recorded in all
      patients. RESULTS: Transdochal LCDL was performed on 172 consecutive patients.
      Five patients had a prior open cholecystectomy, 26 patients presented with acute 
      cholecystitis, 5 patients presented with mild acute pancreatitis, and 12 patients
      presented after failed endoscopic retrograde cholangiopancreatography.
      Twenty-eight (16.28%) patients had multiple stones, 2 had biliary sludge, and no 
      stone was found in 3 patients. Stone size varied from 4 to 12 mm. The average
      operative time was 68 minutes (range, 45-127 minutes). Primary repair was
      performed with 3-0 Vicryl continuous sutures, and the T tube was left in place in
      13 (7.56%) patients. Conversion to an open procedure was required in 8 patients
      (4.65%). Postoperatively, mild acute pancreatitis occurred in 1 patient, and
      biliary peritonitis occurred in 5 patients. CONCLUSIONS: Rigid scope transdochal 
      LCDL is feasible, probably easier, better for impacted large CBD stones, and
      definitely more affordable.
FAU - Sinha, Rajeev
AU  - Sinha R
AD  - Department of Surgery, MLB Medical College, Jhansi, Uttar Pradesh, India.
      sinha_rga@yahoo.co.in
LA  - eng
PT  - Journal Article
DEP - 20121114
PL  - United States
TA  - J Laparoendosc Adv Surg Tech A
JT  - Journal of laparoendoscopic & advanced surgical techniques. Part A
JID - 9706293
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cholecystectomy, Laparoscopic/*instrumentation
MH  - Equipment Design
MH  - Female
MH  - Gallstones/*surgery
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Young Adult
EDAT- 2012/11/16 06:00
MHDA- 2013/08/27 06:00
CRDT- 2012/11/16 06:00
PHST- 2012/11/16 06:00 [entrez]
PHST- 2012/11/16 06:00 [pubmed]
PHST- 2013/08/27 06:00 [medline]
AID - 10.1089/lap.2012.0303 [doi]
PST - ppublish
SO  - J Laparoendosc Adv Surg Tech A. 2013 Mar;23(3):211-5. doi: 10.1089/lap.2012.0303.
      Epub 2012 Nov 14.


PMID- 23151109
OWN - NLM
STAT- MEDLINE
DCOM- 20131202
LR  - 20121115
IS  - 1365-2834 (Electronic)
IS  - 0966-0429 (Linking)
VI  - 20
IP  - 8
DP  - 2012 Dec
TI  - Spiritual leadership and spiritual care in neonatology.
PG  - 1069-75
LID - 10.1111/jonm.12034 [doi]
AB  - AIM: This article aims to explore spiritual care in the neonatal care environment
      in addition to highlighting the importance of spiritual leadership of a health
      team in that context. BACKGROUND: Neonatal care is an ethically demanding and
      stressful area of practice. Babies and families require spiritual needs to be
      recognized in the context of holistic care. Literature around spiritual
      leadership is explored to nurture workplace spirituality. EVALUATION: Analysis of
      a range of sources provides a theoretical reflection on spiritual leadership and 
      spiritual care in neonatal care settings. KEY ISSUES: The literature identifies
      that the carers should consider carefully on how care given may affect the infant
      and family. Themes relating to the baby's and family's spiritual needs and those 
      of the staff in this area are identified. Spiritual leadership by the manager
      will provide support to the staff and help spiritual need to be met in this area 
      of practice. CONCLUSION: Spiritual needs should be acknowledged within neonatal
      care whether these are of babies, families or the team itself. IMPLICATIONS FOR
      NURSING MANAGEMENT: Managers have responsibility to ensure that spiritual care is
      carried out for babies and their families and to care for the team as spiritual
      leaders.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Caldeira, Silvia
AU  - Caldeira S
AD  - Institute of Health Sciences, The Catholic University of Portugal, Lisbon,
      Portugal.
FAU - Hall, Jenny
AU  - Hall J
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Nurs Manag
JT  - Journal of nursing management
JID - 9306050
MH  - Holistic Nursing/*methods
MH  - Humans
MH  - Infant, Newborn
MH  - Intensive Care Units, Neonatal
MH  - *Leadership
MH  - Neonatal Nursing/*methods
MH  - Nurse Administrators
MH  - Nurse's Role
MH  - Patient Care Team/*organization & administration
MH  - *Spirituality
EDAT- 2012/11/16 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/11/16 06:00
PHST- 2012/11/16 06:00 [entrez]
PHST- 2012/11/16 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1111/jonm.12034 [doi]
PST - ppublish
SO  - J Nurs Manag. 2012 Dec;20(8):1069-75. doi: 10.1111/jonm.12034.


PMID- 23150079
OWN - NLM
STAT- MEDLINE
DCOM- 20131021
LR  - 20211021
IS  - 1476-5438 (Electronic)
IS  - 1018-4813 (Linking)
VI  - 21
IP  - 6
DP  - 2013 Jun
TI  - How can ethics relate to science? The case of stem cell research.
PG  - 591-5
LID - 10.1038/ejhg.2012.232 [doi]
AB  - We live in an era of an important turning point in the relationship between
      ethics (or, more accurately, bioethics) and science, notably due to both public
      interest and the gradual tightening of the gap in time between scientific
      discoveries and ethical reflection. The current bioethics debates of emerging
      situations (pluripotent stem cells, gene therapy, nanotechnology) have
      undoubtedly contributed to this change. Today, science happens and bioethics
      reflects on the possibilities, considers the risks, and advances proposals,
      which, without being scientific, can also imprint a mark on the path of
      scientific development. In this article, through the narrative of stem cell
      research, we will try to illustrate how bringing a bioethical viewpoint to the
      scientific debate can become a healthy exercise in both ethics and science,
      especially as narratives shift, as was the case in this field due to the
      introduction of induced pluripotent stem cells, the advent of which is not easily
      dissociated from the controversies related to embryo research. We should perhaps 
      welcome this trend as promising for the future relationship between ethics and
      scientific research, providing a stimulus (and not a block) to the ever-evolving 
      scientific discourse.
FAU - Carvalho, Ana Sofia
AU  - Carvalho AS
AD  - Centro de Investigacao em Bioetica, Instituto Bioetica da Universidade Catolica, 
      Porto, Portugal. acarvalhoporto@ucp.pt
FAU - Ramalho-Santos, Joao
AU  - Ramalho-Santos J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121114
PL  - England
TA  - Eur J Hum Genet
JT  - European journal of human genetics : EJHG
JID - 9302235
SB  - IM
MH  - Humans
MH  - Pluripotent Stem Cells/cytology
MH  - Research Embryo Creation/ethics
MH  - Science/*ethics
MH  - Stem Cell Research/*ethics
PMC - PMC3658189
EDAT- 2012/11/15 06:00
MHDA- 2013/10/22 06:00
CRDT- 2012/11/15 06:00
PHST- 2012/11/15 06:00 [entrez]
PHST- 2012/11/15 06:00 [pubmed]
PHST- 2013/10/22 06:00 [medline]
AID - ejhg2012232 [pii]
AID - 10.1038/ejhg.2012.232 [doi]
PST - ppublish
SO  - Eur J Hum Genet. 2013 Jun;21(6):591-5. doi: 10.1038/ejhg.2012.232. Epub 2012 Nov 
      14.


PMID- 23149977
OWN - NLM
STAT- MEDLINE
DCOM- 20130111
LR  - 20211203
IS  - 1940-087X (Electronic)
IS  - 1940-087X (Linking)
IP  - 68
DP  - 2012 Oct 31
TI  - Generation of human induced pluripotent stem cells from peripheral blood using
      the STEMCCA lentiviral vector.
LID - 10.3791/4327 [doi]
LID - 4327 [pii]
AB  - Through the ectopic expression of four transcription factors, Oct4, Klf4, Sox2
      and cMyc, human somatic cells can be converted to a pluripotent state, generating
      so-called induced pluripotent stem cells (iPSCs)(1-4). Patient-specific iPSCs
      lack the ethical concerns that surround embryonic stem cells (ESCs) and would
      bypass possible immune rejection. Thus, iPSCs have attracted considerable
      attention for disease modeling studies, the screening of pharmacological
      compounds, and regenerative therapies(5). We have shown the generation of
      transgene-free human iPSCs from patients with different lung diseases using a
      single excisable polycistronic lentiviral Stem Cell Cassette (STEMCCA) encoding
      the Yamanaka factors(6). These iPSC lines were generated from skin fibroblasts,
      the most common cell type used for reprogramming. Normally, obtaining fibroblasts
      requires a skin punch biopsy followed by expansion of the cells in culture for a 
      few passages. Importantly, a number of groups have reported the reprogramming of 
      human peripheral blood cells into iPSCs(7-9). In one study, a Tet inducible
      version of the STEMCCA vector was employed(9), which required the blood cells to 
      be simultaneously infected with a constitutively active lentivirus encoding the
      reverse tetracycline transactivator. In contrast to fibroblasts, peripheral blood
      cells can be collected via minimally invasive procedures, greatly reducing the
      discomfort and distress of the patient. A simple and effective protocol for
      reprogramming blood cells using a constitutive single excisable vector may
      accelerate the application of iPSC technology by making it accessible to a
      broader research community. Furthermore, reprogramming of peripheral blood cells 
      allows for the generation of iPSCs from individuals in which skin biopsies should
      be avoided (i.e. aberrant scarring) or due to pre-existing disease conditions
      preventing access to punch biopsies. Here we demonstrate a protocol for the
      generation of human iPSCs from peripheral blood mononuclear cells (PBMCs) using a
      single floxed-excisable lentiviral vector constitutively expressing the 4
      factors. Freshly collected or thawed PBMCs are expanded for 9 days as
      described(10,11) in medium containing ascorbic acid, SCF, IGF-1, IL-3 and EPO
      before being transduced with the STEMCCA lentivirus. Cells are then plated onto
      MEFs and ESC-like colonies can be visualized two weeks after infection. Finally, 
      selected clones are expanded and tested for the expression of the pluripotency
      markers SSEA-4, Tra-1-60 and Tra-1-81. This protocol is simple, robust and highly
      consistent, providing a reliable methodology for the generation of human iPSCs
      from readily accessible 4 ml of blood.
FAU - Sommer, Andreia Gianotti
AU  - Sommer AG
AD  - Center for Regenerative Medicine (CReM), Boston University School of Medicine.
FAU - Rozelle, Sarah S
AU  - Rozelle SS
FAU - Sullivan, Spencer
AU  - Sullivan S
FAU - Mills, Jason A
AU  - Mills JA
FAU - Park, Seon-Mi
AU  - Park SM
FAU - Smith, Brenden W
AU  - Smith BW
FAU - Iyer, Amulya M
AU  - Iyer AM
FAU - French, Deborah L
AU  - French DL
FAU - Kotton, Darrell N
AU  - Kotton DN
FAU - Gadue, Paul
AU  - Gadue P
FAU - Murphy, George J
AU  - Murphy GJ
FAU - Mostoslavsky, Gustavo
AU  - Mostoslavsky G
LA  - eng
GR  - K12 HL087064/HL/NHLBI NIH HHS/United States
GR  - T32 HL007501/HL/NHLBI NIH HHS/United States
GR  - U01 HL107443/HL/NHLBI NIH HHS/United States
GR  - UO1HL107443-01/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Video-Audio Media
DEP - 20121031
PL  - United States
TA  - J Vis Exp
JT  - Journal of visualized experiments : JoVE
JID - 101313252
RN  - 0 (Antigens, Surface)
RN  - 0 (KLF4 protein, human)
RN  - 0 (Kruppel-Like Factor 4)
RN  - 0 (Proteoglycans)
RN  - 0 (Stage-Specific Embryonic Antigens)
RN  - 0 (TRA-1-60 antigen, human)
RN  - 0 (TRA-1-81 antigen, human)
RN  - 0 (stage-specific embryonic antigen-4)
SB  - IM
MH  - Antigens, Surface/biosynthesis
MH  - Genetic Vectors/genetics
MH  - Humans
MH  - Kruppel-Like Factor 4
MH  - Lentivirus/*genetics
MH  - Leukocytes, Mononuclear/cytology/metabolism/*physiology
MH  - Pluripotent Stem Cells/cytology/metabolism/*physiology
MH  - Proteoglycans/biosynthesis
MH  - Stage-Specific Embryonic Antigens/biosynthesis
MH  - Transduction, Genetic
PMC - PMC3499070
EDAT- 2012/11/15 06:00
MHDA- 2013/01/12 06:00
CRDT- 2012/11/15 06:00
PHST- 2012/11/15 06:00 [entrez]
PHST- 2012/11/15 06:00 [pubmed]
PHST- 2013/01/12 06:00 [medline]
AID - 4327 [pii]
AID - 10.3791/4327 [doi]
PST - epublish
SO  - J Vis Exp. 2012 Oct 31;(68). pii: 4327. doi: 10.3791/4327.


PMID- 23149801
OWN - NLM
STAT- MEDLINE
DCOM- 20130111
LR  - 20211021
IS  - 1940-087X (Electronic)
IS  - 1940-087X (Linking)
IP  - 68
DP  - 2012 Oct 31
TI  - A novel surgical approach for intratracheal administration of bioactive agents in
      a fetal mouse model.
LID - 10.3791/4219 [doi]
LID - 4219 [pii]
AB  - Prenatal pulmonary delivery of cells, genes or pharmacologic agents could provide
      the basis for new therapeutic strategies for a variety of genetic and acquired
      diseases. Apart from congenital or inherited abnormalities with the requirement
      for long-term expression of the delivered gene, several non-inherited perinatal
      conditions, where short-term gene expression or pharmacological intervention is
      sufficient to achieve therapeutic effects, are considered as potential future
      indications for this kind of approach. Candidate diseases for the application of 
      short-term prenatal therapy could be the transient neonatal deficiency of
      surfactant protein B causing neonatal respiratory distress syndrome(1,2) or
      hyperoxic injuries of the neonatal lung(3). Candidate diseases for permanent
      therapeutic correction are Cystic Fibrosis (CF)(4), genetic variants of
      surfactant deficiencies(5) and alpha1-antitrypsin deficiency(6). Generally, an
      important advantage of prenatal gene therapy is the ability to start therapeutic 
      intervention early in development, at or even prior to clinical manifestations in
      the patient, thus preventing irreparable damage to the individual. In addition,
      fetal organs have an increased cell proliferation rate as compared to adult
      organs, which could allow a more efficient gene or stem cell transfer into the
      fetus. Furthermore, in utero gene delivery is performed when the individual's
      immune system is not completely mature. Therefore, transplantation of
      heterologous cells or supplementation of a non-functional or absent protein with 
      a correct version should not cause immune sensitization to the cell, vector or
      transgene product, which has recently been proven to be the case with both
      cellular and genetic therapies(7). In the present study, we investigated the
      potential to directly target the fetal trachea in a mouse model. This procedure
      is in use in larger animal models such as rabbits and sheep(8), and even in a
      clinical setting(9), but has to date not been performed before in a mouse model. 
      When studying the potential of fetal gene therapy for genetic diseases such as
      CF, the mouse model is very useful as a first proof-of-concept because of the
      wide availability of different transgenic mouse strains, the well documented
      embryogenesis and fetal development, less stringent ethical regulations, short
      gestation and the large litter size. Different access routes have been described 
      to target the fetal rodent lung, including intra-amniotic injection(10-12),
      (ultrasound-guided) intrapulmonary injection(13,14) and intravenous
      administration into the yolk sac vessels(15,16) or umbilical vein(17). Our novel 
      surgical procedure enables researchers to inject the agent of choice directly
      into the fetal mouse trachea which allows for a more efficient delivery to the
      airways than existing techniques(18).
FAU - Carlon, Marianne S
AU  - Carlon MS
AD  - Molecular Virology and Gene Therapy, KU Leuven.
FAU - Toelen, Jaan
AU  - Toelen J
FAU - da Cunha, Marina Mori
AU  - da Cunha MM
FAU - Vidovic, Dragana
AU  - Vidovic D
FAU - Van der Perren, Anke
AU  - Van der Perren A
FAU - Mayer, Steffi
AU  - Mayer S
FAU - Sbragia, Lourenco
AU  - Sbragia L
FAU - Nuyts, Johan
AU  - Nuyts J
FAU - Himmelreich, Uwe
AU  - Himmelreich U
FAU - Debyser, Zeger
AU  - Debyser Z
FAU - Deprest, Jan
AU  - Deprest J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Video-Audio Media
DEP - 20121031
PL  - United States
TA  - J Vis Exp
JT  - Journal of visualized experiments : JoVE
JID - 101313252
SB  - IM
MH  - Animals
MH  - Drug Administration Routes
MH  - Female
MH  - Fetal Therapies/*methods
MH  - Fetus
MH  - Male
MH  - Mice
MH  - *Models, Animal
MH  - Pregnancy
MH  - Trachea/*embryology/*surgery
PMC - PMC3499071
EDAT- 2012/11/15 06:00
MHDA- 2013/01/12 06:00
CRDT- 2012/11/15 06:00
PHST- 2012/11/15 06:00 [entrez]
PHST- 2012/11/15 06:00 [pubmed]
PHST- 2013/01/12 06:00 [medline]
AID - 4219 [pii]
AID - 10.3791/4219 [doi]
PST - epublish
SO  - J Vis Exp. 2012 Oct 31;(68). pii: 4219. doi: 10.3791/4219.


PMID- 23149672
OWN - NLM
STAT- MEDLINE
DCOM- 20140122
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 3
DP  - 2013 Sep
TI  - Socio-ethical education in nanotechnology engineering programmes: a case study in
      Malaysia.
PG  - 1341-55
LID - 10.1007/s11948-012-9418-z [doi]
AB  - The unique properties of nanotechnology have made nanotechnology education and
      its related subjects increasingly important not only for students but for mankind
      at large. This particular technology brings educators to work together to prepare
      and produce competent engineers and scientists for this field. One of the key
      challenges in nanotechnology engineering is to produce graduate students who are 
      not only competent in technical knowledge but possess the necessary attitude and 
      awareness toward the social and ethical issues related to nanotechnology. In this
      paper, a research model has been developed to assess Malaysian nanotechnology
      engineering students' attitudes and whether their perspectives have attained the 
      necessary objectives of ethical education throughout their programme of study.
      The findings from this investigation show that socio ethical education has a
      strong influence on the students' knowledge, skills and attitudes pertaining to
      socio ethical issues related to nanotechnology.
FAU - Balakrishnan, Balamuralithara
AU  - Balakrishnan B
AD  - Universiti Pendidikan Sultan Idris, Tanjung Malim, Perak, Malaysia.
      bmthara@gmail.com
FAU - Er, Pek Hoon
AU  - Er PH
FAU - Visvanathan, Punita
AU  - Visvanathan P
LA  - eng
PT  - Journal Article
DEP - 20121113
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Attitude
MH  - *Awareness
MH  - *Curriculum
MH  - Education, Graduate
MH  - Educational Measurement
MH  - Engineering/*education/ethics
MH  - Ethics, Professional/*education
MH  - Ethics, Research/education
MH  - Humans
MH  - Interviews as Topic
MH  - Malaysia
MH  - Nanotechnology/*education/ethics
MH  - Research Design
MH  - Science/education/ethics
MH  - *Social Responsibility
EDAT- 2012/11/15 06:00
MHDA- 2014/01/23 06:00
CRDT- 2012/11/15 06:00
PHST- 2012/05/26 00:00 [received]
PHST- 2012/11/06 00:00 [accepted]
PHST- 2012/11/15 06:00 [entrez]
PHST- 2012/11/15 06:00 [pubmed]
PHST- 2014/01/23 06:00 [medline]
AID - 10.1007/s11948-012-9418-z [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Sep;19(3):1341-55. doi: 10.1007/s11948-012-9418-z. Epub 2012
      Nov 13.


PMID- 23149236
OWN - NLM
STAT- MEDLINE
DCOM- 20140117
LR  - 20130423
IS  - 1532-3099 (Electronic)
IS  - 0266-6138 (Linking)
VI  - 29
IP  - 5
DP  - 2013 May
TI  - Working and learning: post-registration student midwives' experience of the
      competency assessment process.
PG  - 519-25
LID - 10.1016/j.midw.2012.04.010 [doi]
LID - S0266-6138(12)00064-2 [pii]
AB  - AIM: to explore student midwives experiences of the Clinical Competency
      Assessment process utilised on the Higher Diploma in Midwifery (18 month)
      programme. BACKGROUND: the assessment of clinical skills and practice has
      traditionally been an integral part of midwifery educational programmes; however 
      the method of clinical assessment has changed and developed. Similar to other
      countries, in Ireland assessment of clinical practice is achieved through the
      utilisation of a broad competency framework provided by the regulatory body, An
      Bord Altranais (2005) which is yet to be evaluated from a midwifery perspective. 
      METHOD: a descriptive qualitative study was undertaken once ethical approval had 
      been granted by the University's Ethics Committee. All student midwives (n=20) in
      one cohort were invited to participate and nine students were interviewed.
      Interviews were tape recorded. Data were analysed using Burnard's (2006)
      framework. FINDINGS: the process of competency assessment was perceived by many
      of the students to facilitate continuous assessment of clinical practice but
      there were issues in relation to the language and the number of competencies to
      be assessed. There were challenges also associated with the written evidence
      required as part of the assessment with many of the students questioning the
      usefulness of this in a clinical assessment. A variety of supports were
      identified and utilised by the students. Continuity and availability of
      preceptors were noted to be factors impacting on completion of the assessment as 
      were the competing demands of clinical care. RECOMMENDATIONS: the findings of
      this small study are congruent with much of the international literature focusing
      on clinical competency models. Consideration needs to be given to identifying and
      integrating into practice, a clearly defined process for competency assessment,
      by all the relevant stakeholders. An opportunity for feedback throughout the
      process is considered very significant and the mechanism for this needs to be
      made explicit in any competency assessment documentation Competency documentation
      currently in use needs to be reviewed in light of the findings of this study and 
      the rationale for inclusion of a written evidence component needs to be carefully
      considered. Further research is warranted in relation to the effectiveness of the
      competency tool in assessing competency in practice.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Bradshaw, Carmel
AU  - Bradshaw C
AD  - Department of Nursing and Midwifery, University of Limerick, Ireland.
      carmel.bradshaw@ul.ie
FAU - Noonan, Maria
AU  - Noonan M
FAU - Barry, Maebh
AU  - Barry M
FAU - Atkinson, Sandra
AU  - Atkinson S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121111
PL  - Scotland
TA  - Midwifery
JT  - Midwifery
JID - 8510930
MH  - Clinical Competence/standards
MH  - Education, Nursing, Baccalaureate
MH  - Educational Measurement/*methods
MH  - Educational Status
MH  - Female
MH  - Humans
MH  - Ireland
MH  - Midwifery/*education
MH  - Nurse Midwives/*standards
MH  - Nursing Care/*standards
MH  - Nursing Education Research
MH  - Pregnancy
MH  - Program Development
EDAT- 2012/11/15 06:00
MHDA- 2014/01/18 06:00
CRDT- 2012/11/15 06:00
PHST- 2011/06/23 00:00 [received]
PHST- 2012/04/16 00:00 [revised]
PHST- 2012/04/20 00:00 [accepted]
PHST- 2012/11/15 06:00 [entrez]
PHST- 2012/11/15 06:00 [pubmed]
PHST- 2014/01/18 06:00 [medline]
AID - S0266-6138(12)00064-2 [pii]
AID - 10.1016/j.midw.2012.04.010 [doi]
PST - ppublish
SO  - Midwifery. 2013 May;29(5):519-25. doi: 10.1016/j.midw.2012.04.010. Epub 2012 Nov 
      11.


PMID- 23149098
OWN - NLM
STAT- MEDLINE
DCOM- 20130128
LR  - 20181023
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 345
DP  - 2012 Nov 13
TI  - The composition of animal ethics committees needs to change.
PG  - e7627
LID - 10.1136/bmj.e7627 [doi]
LID - bmj.e7627 [pii]
FAU - Ashby, Martin
AU  - Ashby M
FAU - Menache, Andre
AU  - Menache A
LA  - eng
PT  - Letter
DEP - 20121113
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
SB  - IM
MH  - Animal Care Committees/*organization & administration
EDAT- 2012/11/15 06:00
MHDA- 2013/01/29 06:00
CRDT- 2012/11/15 06:00
PHST- 2012/11/15 06:00 [entrez]
PHST- 2012/11/15 06:00 [pubmed]
PHST- 2013/01/29 06:00 [medline]
AID - 10.1136/bmj.e7627 [doi]
PST - epublish
SO  - BMJ. 2012 Nov 13;345:e7627. doi: 10.1136/bmj.e7627.


PMID- 23148608
OWN - NLM
STAT- MEDLINE
DCOM- 20130418
LR  - 20211214
IS  - 2050-6511 (Electronic)
IS  - 2050-6511 (Linking)
VI  - 13
DP  - 2012 Nov 13
TI  - Comparison of the anti-inflammatory effects of Cilomilast, Budesonide and a p38
      Mitogen activated protein kinase inhibitor in COPD lung tissue macrophages.
PG  - 15
LID - 10.1186/2050-6511-13-15 [doi]
AB  - Chronic Obstructive Pulmonary Disease (COPD) is a disease characterized by a
      largely irreversible airflow obstruction and a persistent, excessive inflammatory
      response. Alveolar macrophages (AMs) are increased in the lungs of COPD patients,
      and act as orchestrators of the inflammatory response, releasing a range of
      mediators to coordinate recruitment and activation of leukocytes. Attempts to
      treat the inflammatory component of COPD with anti-inflammatory drugs such as
      steroids has met with limited success. In this study, we compared the ability of 
      the phosphodiesterase IV (PDEIV) inhibitor Cilomilast, the steroid Budesonide,
      and the p38 mitogen activated protein kinase inhibitor BIRB-796 to inhibit tumour
      necrosis factor alpha (TNFalpha) and interleukin 6 (IL-6) releases from AMs
      isolated from COPD lung transplant tissue. All studies were carried out with
      appropriate ethical approval and written, informed consent was obtained from each
      subject. Cilomilast had little effect on cytokine release from AMs. There was
      considerable variability in the responsiveness of AMs to Budesonide, with a
      subset of AMs responding poorly to Budesonide. BIRB-796 inhibited TNFalpha
      release from all AM donors, including those that responded poorly to steroids.
      Treatment with BIRB-796 and Budesonide together gave an additive decrease in TNFa
      release. These results suggest that a p38 inhibitor may provide advantages over
      existing anti-inflammatory treatments for COPD, either as an add-on to existing
      therapy, or to treat patients who respond poorly to steroids.
FAU - Ratcliffe, Marianne Jennifer
AU  - Ratcliffe MJ
AD  - Personalised Healthcare and Biomarkers, AstraZeneca R&D Alderley Park, Cheshire, 
      SK, 10 4TG, UK. Marianne.ratcliffe@astrazeneca.com
FAU - Dougall, Iain Gordon
AU  - Dougall IG
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20121113
PL  - England
TA  - BMC Pharmacol Toxicol
JT  - BMC pharmacology & toxicology
JID - 101590449
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Cyclohexanecarboxylic Acids)
RN  - 0 (Interleukin-6)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Naphthalenes)
RN  - 0 (Nitriles)
RN  - 0 (Phosphodiesterase 4 Inhibitors)
RN  - 0 (Protein Kinase Inhibitors)
RN  - 0 (Pyrazoles)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 51333-22-3 (Budesonide)
RN  - 8ATB1C1R6X (Cilomilast)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
RN  - HO1A8B3YVV (doramapimod)
SB  - IM
MH  - Anti-Inflammatory Agents/*pharmacology
MH  - Budesonide/pharmacology
MH  - Cells, Cultured
MH  - Cyclohexanecarboxylic Acids/pharmacology
MH  - Female
MH  - Humans
MH  - Interleukin-6/immunology
MH  - Lipopolysaccharides
MH  - Macrophages, Alveolar/*drug effects/immunology
MH  - Male
MH  - Middle Aged
MH  - Naphthalenes/pharmacology
MH  - Nitriles/pharmacology
MH  - Phosphodiesterase 4 Inhibitors/*pharmacology
MH  - Protein Kinase Inhibitors/*pharmacology
MH  - *Pulmonary Disease, Chronic Obstructive
MH  - Pyrazoles/pharmacology
MH  - Tumor Necrosis Factor-alpha/immunology
MH  - p38 Mitogen-Activated Protein Kinases/*antagonists & inhibitors
PMC - PMC3534411
EDAT- 2012/11/15 06:00
MHDA- 2013/04/20 06:00
CRDT- 2012/11/15 06:00
PHST- 2012/02/23 00:00 [received]
PHST- 2012/10/23 00:00 [accepted]
PHST- 2012/11/15 06:00 [entrez]
PHST- 2012/11/15 06:00 [pubmed]
PHST- 2013/04/20 06:00 [medline]
AID - 2050-6511-13-15 [pii]
AID - 10.1186/2050-6511-13-15 [doi]
PST - epublish
SO  - BMC Pharmacol Toxicol. 2012 Nov 13;13:15. doi: 10.1186/2050-6511-13-15.


PMID- 23148602
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130110
LR  - 20211021
IS  - 1750-1164 (Electronic)
IS  - 1750-1164 (Linking)
VI  - 6
IP  - 1
DP  - 2012 Nov 13
TI  - Improved access and visibility during stapling of the ultra-low rectum: a
      comparative human cadaver study between two curved staplers.
PG  - 11
LID - 10.1186/1750-1164-6-11 [doi]
AB  - UNLABELLED: BACKGROUND: The purpose of this study was to compare in human
      cadavers the applicability of a commonly used stapling device, the CONTOUR(R)
      curved cutter (CC) (Ethicon Endo-Surgery, Cincinnati, OH) to a newly released,
      curved stapler, the Endo GIA Radial Reload with Tri-Staple Technology (RR)
      (Covidien, New Haven, CT) METHODS: Four experienced surgeons performed deep
      pelvic dissection with total mesorectal excision (TME) of the rectum in twelve
      randomized male cadavers. Both stapling devices were applied to the ultra-low
      rectum in coronal and sagittal configurations. Extensive measurements were
      recorded of anatomic landmarks for each cadaver pelvis along with various aspects
      of access, visibility, and ease of placement for each device. RESULTS: The RR
      reached significantly lower into the pelvis in both the coronal and sagittal
      positions compared to the CC. The median distance from the pelvic floor was 1.0
      cm compared to 2.0 cm in the coronal position, and 1.0 cm versus 3.3 cm placed
      sagitally, p < 0.0001. Surgeons gave a higher visibility rating with less visual 
      impediment in the sagittal plane using the RR Stapler. Impediment of visibility
      occurred in only 10% (5/48) of RR applications in the coronal position, compared 
      to a rate of 48% (23/48) using the CC, p = 0.0002. CONCLUSIONS: The RR device
      performed significantly better when compared to the CC stapler in regards to
      placing the stapler further into the deep pelvis and closer to the pelvic floor, 
      while causing less obstructing of visualization.
FAU - Rivadeneira, David E
AU  - Rivadeneira DE
AD  - Saint Catherine of Siena Medical Center, Smithtown, NY, USA.
      david.rivadeneira@chsli.org.
FAU - Verdeja, Juan Carlos
AU  - Verdeja JC
FAU - Sonoda, Toyooki
AU  - Sonoda T
LA  - eng
PT  - Journal Article
DEP - 20121113
PL  - England
TA  - Ann Surg Innov Res
JT  - Annals of surgical innovation and research
JID - 101266580
PMC - PMC3539907
EDAT- 2012/11/15 06:00
MHDA- 2012/11/15 06:01
CRDT- 2012/11/15 06:00
PHST- 2012/06/01 00:00 [received]
PHST- 2012/10/22 00:00 [accepted]
PHST- 2012/11/15 06:00 [entrez]
PHST- 2012/11/15 06:00 [pubmed]
PHST- 2012/11/15 06:01 [medline]
AID - 1750-1164-6-11 [pii]
AID - 10.1186/1750-1164-6-11 [doi]
PST - epublish
SO  - Ann Surg Innov Res. 2012 Nov 13;6(1):11. doi: 10.1186/1750-1164-6-11.


PMID- 23148348
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121119
LR  - 20220129
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 6
DP  - 2012
TI  - Support and assessment for fall emergency referrals (SAFER 2) research protocol: 
      cluster randomised trial of the clinical and cost effectiveness of new protocols 
      for emergency ambulance paramedics to assess and refer to appropriate
      community-based care.
LID - 10.1136/bmjopen-2012-002169 [doi]
LID - e002169 [pii]
AB  - INTRODUCTION: Emergency calls to ambulance services are frequent for older people
      who have fallen, but ambulance crews often leave patients at the scene without
      ongoing care. Evidence shows that when left at home with no further support older
      people often experience subsequent falls which result in injury and
      emergency-department attendances. SAFER 2 is an evaluation of a new clinical
      protocol which allows paramedics to assess and refer older people who have
      fallen, and do not need hospital care, to community-based falls services. In this
      protocol paper, we report methods and progress during trial implementation. SAFER
      2 is recruiting patients through three ambulance services. A successful trial
      will provide robust evidence about the value of this new model of care, and
      enable ambulance services to use resources efficiently. DESIGN: Pragmatic cluster
      randomised trial. METHODS AND ANALYSIS: We randomly allocated 25 participating
      ambulance stations (clusters) in three services to intervention or control group.
      Intervention paramedics received training and clinical protocols for assessing
      and referring older people who have fallen to community-based falls services when
      appropriate, while control paramedics deliver care as usual. Patients are
      eligible for the trial if they are aged 65 or over; resident in a participating
      falls service catchment area; and attended by a trial paramedic following an
      emergency call coded as a fall without priority symptoms. The principal outcome
      is the rate of further emergency contacts (or death), for any cause and for
      falls. Secondary outcomes include further falls, health-related quality of life, 
      'fear of falling', patient satisfaction reported by participants through postal
      questionnaires at 1 and 6 months, and quality and pathways of care at the index
      incident. We shall compare National Health Service (NHS) and patient/carer costs 
      between intervention and control groups and estimate quality-adjusted life years 
      (QALYs) gained from the intervention and thus incremental cost per QALY. We shall
      estimate wider system effects on key-performance indicators. We shall interview
      60 intervention patients, and conduct focus groups with contributing NHS staff to
      explore their experiences of the assessment and referral service. We shall
      analyse quantitative trial data by 'treatment allocated'; and qualitative data
      using content analysis. ETHICS AND DISSEMINATION: The Research Ethics Committee
      for Wales gave ethical approval and each participating centre gave NHS Research
      and Development approval. We shall disseminate study findings through
      peer-reviewed publications and conference presentations. TRIAL REGISTRATION:
      ISRCTN 60481756.
FAU - Snooks, Helen
AU  - Snooks H
AD  - Centre for Health Information Research and Evaluation, Swansea University,
      Swansea, UK.
FAU - Anthony, Rebecca
AU  - Anthony R
FAU - Chatters, Robin
AU  - Chatters R
FAU - Cheung, Wai-Yee
AU  - Cheung WY
FAU - Dale, Jeremy
AU  - Dale J
FAU - Donohoe, Rachael
AU  - Donohoe R
FAU - Gaze, Sarah
AU  - Gaze S
FAU - Halter, Mary
AU  - Halter M
FAU - Koniotou, Marina
AU  - Koniotou M
FAU - Logan, Phillippa
AU  - Logan P
FAU - Lyons, Ronan
AU  - Lyons R
FAU - Mason, Suzanne
AU  - Mason S
FAU - Nicholl, Jon
AU  - Nicholl J
FAU - Phillips, Ceri
AU  - Phillips C
FAU - Phillips, Judith
AU  - Phillips J
FAU - Russell, Ian
AU  - Russell I
FAU - Siriwardena, A Niroshan
AU  - Siriwardena AN
FAU - Wani, Mushtaq
AU  - Wani M
FAU - Watkins, Alan
AU  - Watkins A
FAU - Whitfield, Richard
AU  - Whitfield R
FAU - Wilson, Lynsey
AU  - Wilson L
LA  - eng
GR  - 07/01/21/DH_/Department of Health/United Kingdom
GR  - MR/K006525/1/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
DEP - 20121112
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3533098
EDAT- 2012/11/14 06:00
MHDA- 2012/11/14 06:01
CRDT- 2012/11/14 06:00
PHST- 2012/11/14 06:00 [entrez]
PHST- 2012/11/14 06:00 [pubmed]
PHST- 2012/11/14 06:01 [medline]
AID - bmjopen-2012-002169 [pii]
AID - 10.1136/bmjopen-2012-002169 [doi]
PST - epublish
SO  - BMJ Open. 2012 Nov 12;2(6). pii: bmjopen-2012-002169. doi:
      10.1136/bmjopen-2012-002169. Print 2012.


PMID- 23148345
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121119
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 6
DP  - 2012
TI  - Effect of bile acid sequestrants on glycaemic control: protocol for a systematic 
      review with meta-analysis of randomised controlled trials.
LID - 10.1136/bmjopen-2012-001803 [doi]
LID - e001803 [pii]
AB  - INTRODUCTION: In addition to the lipid-lowering effect of bile acid sequestrants 
      (BASs), they also lower blood glucose and, therefore, could be beneficial in the 
      treatment of patients with type 2 diabetes mellitus (T2DM). Three oral BASs are
      approved by the US Food and Drug Administration (FDA) for the treatment of
      hypercholesterolaemia: colestipol, cholestyramine and colesevelam. The BAS
      colestimide/colestilan is used in Japan. Colesevelam was recently approved by the
      FDA for the treatment of T2DM. We plan to provide a systematic review with
      meta-analysis of the glucose-lowering effect of BASs with the aim to evaluate
      their potential as glucose-lowering agents in patients with T2DM. METHODS AND
      ANALYSIS: In accordance with the preferred reporting items for systematic reviews
      and meta-analyses statement, a systematic review with meta-analysis of randomised
      clinical trials of BASs (vs placebo, oral antidiabetes drugs or insulin),
      reporting measures of glycaemic control in adult patients with T2DM, will be
      performed. Change in glycated haemoglobin constitutes the primary endpoint, and
      secondary endpoints include changes in fasting plasma glucose, low-density
      lipoprotein cholesterol, high-density lipoprotein cholesterol, total cholesterol,
      triglycerides, body weight and body mass index and adverse events. Electronic
      searches will be performed in The Cochrane Library, MEDLINE and EMBASE, along
      with manual searches in the reference lists of relevant papers. The analyses will
      be performed based on individual patient data and summarised data. The primary
      meta-analysis will be performed using random effects models owing to expected
      intertrial heterogeneity. Dichotomous data will be analysed using risk difference
      and continuous data using weighted mean differences, both with 95% CIs. ETHICS
      AND DISSEMINATION: The study will evaluate the potential of BASs as
      glucose-lowering agents and possibly contribute to the clinical management of
      patients with T2DM. RESULTS: The study will be disseminated by peer-review
      publication and conference presentation. PROTOCOL REGISTRATION: PROSPERO
      CRD42012002552.
FAU - Hansen, Morten
AU  - Hansen M
AD  - Diabetes Research Division, Department of Internal Medicine, Gentofte Hospital,
      University of Copenhagen, Hellerup, Denmark.
FAU - Sonne, David Peick
AU  - Sonne DP
FAU - Mikkelsen, Kristian Hallundbaek
AU  - Mikkelsen KH
FAU - Gluud, Lise Lotte
AU  - Gluud LL
FAU - Vilsboll, Tina
AU  - Vilsboll T
FAU - Knop, Filip Krag
AU  - Knop FK
LA  - eng
PT  - Journal Article
DEP - 20121112
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3533035
EDAT- 2012/11/14 06:00
MHDA- 2012/11/14 06:01
CRDT- 2012/11/14 06:00
PHST- 2012/11/14 06:00 [entrez]
PHST- 2012/11/14 06:00 [pubmed]
PHST- 2012/11/14 06:01 [medline]
AID - bmjopen-2012-001803 [pii]
AID - 10.1136/bmjopen-2012-001803 [doi]
PST - epublish
SO  - BMJ Open. 2012 Nov 12;2(6). pii: bmjopen-2012-001803. doi:
      10.1136/bmjopen-2012-001803. Print 2012.


PMID- 23147988
OWN - NLM
STAT- MEDLINE
DCOM- 20130524
LR  - 20151119
IS  - 1097-0223 (Electronic)
IS  - 0197-3851 (Linking)
VI  - 32
IP  - 13
DP  - 2012 Dec
TI  - What do French patients and geneticists think about prenatal and preimplantation 
      diagnoses in Marfan syndrome?
PG  - 1318-23
LID - 10.1002/pd.4008 [doi]
AB  - OBJECTIVES: Marfan syndrome (MFS) is an autosomal dominant connective tissue
      disorder with manifestations mainly involving the skeletal, ocular, and
      cardiovascular systems. The phenotypic variability observed in MFS makes genetic 
      counselling difficult. Prenatal diagnosis (PND) and preimplantation genetic
      diagnosis are technically feasible when a causal mutation is identified, but both
      raise many ethical questions in this condition. Little is known about opinions
      and practices in such reproductive issues in MFS. The goal of this study was to
      report on patients' points of view and geneticists' standard practices. METHODS: 
      Two different questionnaires were produced. RESULTS: Fifty geneticists filled in 
      the questionnaire. Twenty-two per cent thought that PND was acceptable, 72%
      debatable and 6% not acceptable. Preimplantation genetic diagnosis was more often
      reported acceptable (34% of answers). Results varied according to the physician's
      experience with the disease. Fifty-four answers were collected for patients'
      questionnaires. Most of them (74%) were favourable to the development of prenatal
      testing, and believed that the choice should be given to parents. However, only a
      minority would opt for prenatal diagnosis for themselves. CONCLUSION: This study 
      showed that the majority of patients were in favour of PND and that opinions
      among practitioners varied widely, but that overall, practitioners favoured a
      systematic multidisciplinary evaluation of the couple's request.
CI  - (c) 2012 John Wiley & Sons, Ltd.
FAU - Coron, F
AU  - Coron F
AD  - Centre de Genetique et Centre de Reference Anomalies du Developpement et
      Syndromes Malformatifs, Hopital d'Enfants, CHU Dijon et Universite de Bourgogne, 
      Dijon, France.
FAU - Rousseau, T
AU  - Rousseau T
FAU - Jondeau, G
AU  - Jondeau G
FAU - Gautier, E
AU  - Gautier E
FAU - Binquet, C
AU  - Binquet C
FAU - Gouya, L
AU  - Gouya L
FAU - Cusin, V
AU  - Cusin V
FAU - Odent, S
AU  - Odent S
FAU - Dulac, Y
AU  - Dulac Y
FAU - Plauchu, H
AU  - Plauchu H
FAU - Collignon, P
AU  - Collignon P
FAU - Delrue, M-A
AU  - Delrue MA
FAU - Leheup, B
AU  - Leheup B
FAU - Joly, L
AU  - Joly L
FAU - Huet, F
AU  - Huet F
FAU - Thevenon, J
AU  - Thevenon J
FAU - Mace, G
AU  - Mace G
FAU - Cassini, C
AU  - Cassini C
FAU - Thauvin-Robinet, C
AU  - Thauvin-Robinet C
FAU - Wolf, J E
AU  - Wolf JE
FAU - Hanna, N
AU  - Hanna N
FAU - Sagot, P
AU  - Sagot P
FAU - Boileau, C
AU  - Boileau C
FAU - Faivre, L
AU  - Faivre L
LA  - eng
PT  - Journal Article
DEP - 20121113
PL  - England
TA  - Prenat Diagn
JT  - Prenatal diagnosis
JID - 8106540
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - France
MH  - Genetics, Medical/*statistics & numerical data
MH  - Humans
MH  - Male
MH  - Marfan Syndrome/*diagnosis/psychology
MH  - Middle Aged
MH  - Parents/*psychology
MH  - Preimplantation Diagnosis/*psychology
MH  - Prenatal Diagnosis/*psychology
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2012/11/14 06:00
MHDA- 2013/05/28 06:00
CRDT- 2012/11/14 06:00
PHST- 2012/11/14 06:00 [entrez]
PHST- 2012/11/14 06:00 [pubmed]
PHST- 2013/05/28 06:00 [medline]
AID - 10.1002/pd.4008 [doi]
PST - ppublish
SO  - Prenat Diagn. 2012 Dec;32(13):1318-23. doi: 10.1002/pd.4008. Epub 2012 Nov 13.


PMID- 23147944
OWN - NLM
STAT- MEDLINE
DCOM- 20130724
LR  - 20190823
IS  - 1678-4464 (Electronic)
IS  - 0102-311X (Linking)
VI  - 28
IP  - 11
DP  - 2012 Nov
TI  - [The morality of nanotechnology].
PG  - 2023-33
LID - S0102-311X2012001100002 [pii]
AB  - Nanotechnology is a set of knowledge, techniques, and practices in studying and
      exploring new properties of materials that arise when manipulated at the atomic
      and molecular levels. The technical possibility of organizing and controlling
      matter at the smallest dimensions and units can result in profound changes in
      industrial production processes and have significant moral impacts on human
      relations, organization of the current social order, and even life as a
      phenomenon. However, moral reflection on nanotechnology has been criticized over 
      the assertion that nanotechnology fails to raise any new ethical issue, for
      example. The current article discusses the limits of this claim by presenting two
      aspects that distinguish between nanotechnology and earlier biotechnoscientific
      advances in terms of their ethical implications: (a) uncertainty as an epistemic 
      characteristic and (b) the threat to the current symbolic character of DNA as the
      "code of life".
FAU - Pyrrho, Monique
AU  - Pyrrho M
AD  - Programa de Pos-graduacaoem Bioetica, Universidade de Brasilia, Brasilia, Brasil.
      pyrrho.monique@gmail.com
FAU - Schramm, Fermin Roland
AU  - Schramm FR
LA  - por
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - A moralidade da nanotecnologia.
PL  - Brazil
TA  - Cad Saude Publica
JT  - Cadernos de saude publica
JID - 8901573
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - *Bioethical Issues
MH  - DNA/*genetics
MH  - Humans
MH  - Life
MH  - Nanostructures
MH  - Nanotechnology/*ethics
MH  - Uncertainty
EDAT- 2012/11/14 06:00
MHDA- 2013/07/25 06:00
CRDT- 2012/11/14 06:00
PHST- 2012/02/28 00:00 [received]
PHST- 2012/08/17 00:00 [accepted]
PHST- 2012/11/14 06:00 [entrez]
PHST- 2012/11/14 06:00 [pubmed]
PHST- 2013/07/25 06:00 [medline]
AID - S0102-311X2012001100002 [pii]
AID - 10.1590/s0102-311x2012001100002 [doi]
PST - ppublish
SO  - Cad Saude Publica. 2012 Nov;28(11):2023-33. doi: 10.1590/s0102-311x2012001100002.


PMID- 23147881
OWN - NLM
STAT- MEDLINE
DCOM- 20131211
LR  - 20220330
IS  - 0379-5284 (Print)
IS  - 0379-5284 (Linking)
VI  - 33
IP  - 11
DP  - 2012 Nov
TI  - Admission criteria to Saudi medical schools. Which is the best predictor for
      successful achievement?
PG  - 1222-6
AB  - OBJECTIVE: To assess the relationship between current pre-admission criteria and 
      medical student's grade point average (GPA) at the end of year 6 in 3 medical
      schools in the Kingdom of Saudi Arabia. METHODS: We conducted this observational 
      analytical study at 3 government medical schools in the Kingdom of Saudi Arabia
      between January 2011 and February 2012. High school grades, achievement test
      (Tahsili test) scores, aptitude test (Qudraat tests) scores, Mathematics, and
      English grades in the high school were used to predict medical student's GPA at
      the end of year 6. The criterion variable was student's cumulative GPA at the end
      of year 6. Correlation between pre-admission variables and GPA was calculated
      using Pearson's correlation, and multiple regression analyses. The Institutional 
      review board and ethical committee at Taif Medical College approved the study.
      RESULTS: We included 727 students in this study from the chosen medical schools. 
      A significant positive correlation was observed among all pre-admission variables
      and GPA. Inclusion of all 5 sets in multiple regression analyses revealed that
      the achievement test, English grade in the high school, high school grade and
      aptitude test (Qudraat tests) were statistically predictive of GPA. A 20.8%
      variance in the GPA can be accounted for by the pre-admission criteria.
      CONCLUSION: Multiple pre-admission factors predict medical students GPA.
      Achievement test is the most important predictor. High school grades in English
      emerged as an independent predictor. Medical schools should give more attention
      to these predictors during admissions.
FAU - Albishri, Jamal A
AU  - Albishri JA
AD  - Department of Medicine, Faculty of Medicine, Taif University, Taif, Kingdom of
      Saudi Arabia. Jbeshri@gmail.com
FAU - Aly, Syed M
AU  - Aly SM
FAU - Alnemary, Yasir
AU  - Alnemary Y
LA  - eng
PT  - Journal Article
PL  - Saudi Arabia
TA  - Saudi Med J
JT  - Saudi medical journal
JID - 7909441
SB  - IM
MH  - *Achievement
MH  - College Admission Test
MH  - Humans
MH  - Retrospective Studies
MH  - Saudi Arabia
MH  - *School Admission Criteria
MH  - *Schools, Medical
EDAT- 2012/11/14 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/11/14 06:00
PHST- 2012/11/14 06:00 [entrez]
PHST- 2012/11/14 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 20120451' [pii]
PST - ppublish
SO  - Saudi Med J. 2012 Nov;33(11):1222-6.


PMID- 23147526
OWN - NLM
STAT- MEDLINE
DCOM- 20130327
LR  - 20191112
IS  - 1473-2262 (Electronic)
IS  - 1473-2262 (Linking)
VI  - 24
DP  - 2012 Nov 12
TI  - Large animal model for osteoporosis in humans: the ewe.
PG  - 372-85
AB  - Osteoporosis is a chronic systemic disease characterised by bone loss and
      microarchitectural deterioration. Since the underlying regulatory mechanisms are 
      still not fully understood and treatment options are not satisfactorily resolved,
      massive efforts are underway to further investigate this critical illness. Large 
      animal models are stipulated, e.g. by the Food and Drug Administration, for
      preclinical prevention and intervention studies related to osteoporosis research;
      in this context, the ewe has already proven its value for orthopaedic research.
      Although oestrogen deficiency doubtless influences bone metabolism in sheep, the 
      ovariectomised ewe seems unsuitable as a model for postmenopausal osteoporosis
      and bone loss induction due to its unreliable impact on bone mass and structure. 
      In contrast, glucocorticoid treatment has a major impact on bone turnover and
      leads to bone conditions comparable to those found in steroid-treated humans.
      However, adverse side effects can be dramatic resulting in unacceptable
      discomfort and illness of the experimental animals. Further improvements are
      therefore essential to judge this model as ethically appropriate. Additionally,
      models for osteoporosis induced by surgical interventions of central regulatory
      mechanisms seem to be attractive, as remarkable bone loss is induced by only one 
      surgical procedure without any further treatment. Taken together, different ewe
      models for osteoporosis have been successfully established and are invaluable for
      orthopaedic research. However, the search for a 'perfect' large remodelling
      animal model - in terms of mimicking the human disease and compatibility of bone 
      loss, and without ethical concerns - is still on-going.
FAU - Oheim, R
AU  - Oheim R
AD  - Department of Osteology and Biomechanics, University Medical Centre
      Hamburg-Eppendorf, Hamburg, Germany.
FAU - Amling, M
AU  - Amling M
FAU - Ignatius, A
AU  - Ignatius A
FAU - Pogoda, P
AU  - Pogoda P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121112
PL  - Switzerland
TA  - Eur Cell Mater
JT  - European cells & materials
JID - 100973416
RN  - 0 (Estrogens)
RN  - 0 (Glucocorticoids)
SB  - IM
MH  - Animals
MH  - Bone Density
MH  - Diet
MH  - *Disease Models, Animal
MH  - Estrogens/metabolism
MH  - Female
MH  - Glucocorticoids/metabolism
MH  - Menopause/metabolism
MH  - Osteoporosis/*etiology
MH  - *Sheep, Domestic
EDAT- 2012/11/14 06:00
MHDA- 2013/03/28 06:00
CRDT- 2012/11/14 06:00
PHST- 2012/11/14 06:00 [entrez]
PHST- 2012/11/14 06:00 [pubmed]
PHST- 2013/03/28 06:00 [medline]
AID - vol024a27 [pii]
AID - 10.22203/ecm.v024a27 [doi]
PST - epublish
SO  - Eur Cell Mater. 2012 Nov 12;24:372-85. doi: 10.22203/ecm.v024a27.


PMID- 23146895
OWN - NLM
STAT- MEDLINE
DCOM- 20130530
LR  - 20211021
IS  - 1469-3178 (Electronic)
IS  - 1469-221X (Linking)
VI  - 13
IP  - 12
DP  - 2012 Dec
TI  - Science and ethics review: the thrill is gone.
PG  - 1032
LID - 10.1038/embor.2012.171 [doi]
FAU - van Helden, Paul
AU  - van Helden P
AD  - Department of Biomedical Science, Stellenbosch University, Faculty of Health
      Science, Tygerberg, Cape Town, South Africa. pvh@sun.ac.za
LA  - eng
PT  - Journal Article
DEP - 20121113
PL  - England
TA  - EMBO Rep
JT  - EMBO reports
JID - 100963049
SB  - IM
MH  - Animals
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Patients
MH  - Science/*ethics
PMC - PMC3512414
EDAT- 2012/11/14 06:00
MHDA- 2013/06/01 06:00
CRDT- 2012/11/14 06:00
PHST- 2012/11/14 06:00 [entrez]
PHST- 2012/11/14 06:00 [pubmed]
PHST- 2013/06/01 06:00 [medline]
AID - embor2012171 [pii]
AID - 10.1038/embor.2012.171 [doi]
PST - ppublish
SO  - EMBO Rep. 2012 Dec;13(12):1032. doi: 10.1038/embor.2012.171. Epub 2012 Nov 13.


PMID- 23146884
OWN - NLM
STAT- MEDLINE
DCOM- 20130530
LR  - 20211021
IS  - 1469-3178 (Electronic)
IS  - 1469-221X (Linking)
VI  - 13
IP  - 12
DP  - 2012 Dec
TI  - Reproduction without sex: social and ethical implications.
PG  - 1049-53
LID - 10.1038/embor.2012.172 [doi]
FAU - Baldwin, Thomas
AU  - Baldwin T
AD  - University of York. thomas.baldwin@york.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20121113
PL  - England
TA  - EMBO Rep
JT  - EMBO reports
JID - 100963049
SB  - IM
MH  - Coitus/physiology
MH  - Fertilization in Vitro/*ethics
MH  - Humans
MH  - Infertility
MH  - Reproduction/*ethics
MH  - Sexual Behavior/*ethics
MH  - Sperm Injections, Intracytoplasmic/ethics
PMC - PMC3512415
EDAT- 2012/11/14 06:00
MHDA- 2013/06/01 06:00
CRDT- 2012/11/14 06:00
PHST- 2012/11/14 06:00 [entrez]
PHST- 2012/11/14 06:00 [pubmed]
PHST- 2013/06/01 06:00 [medline]
AID - embor2012172 [pii]
AID - 10.1038/embor.2012.172 [doi]
PST - ppublish
SO  - EMBO Rep. 2012 Dec;13(12):1049-53. doi: 10.1038/embor.2012.172. Epub 2012 Nov 13.


PMID- 23146581
OWN - NLM
STAT- MEDLINE
DCOM- 20130514
LR  - 20121204
IS  - 1873-7757 (Electronic)
IS  - 0145-2134 (Linking)
VI  - 36
IP  - 11-12
DP  - 2012 Nov-Dec
TI  - The urgent need for ethical guidelines to protect children in the dissemination
      of research findings.
PG  - 798-9
LID - 10.1016/j.chiabu.2012.08.001 [doi]
LID - S0145-2134(12)00191-3 [pii]
FAU - Mudaly, Neerosh
AU  - Mudaly N
FAU - Goddard, Chris
AU  - Goddard C
LA  - eng
PT  - Letter
DEP - 20121110
PL  - England
TA  - Child Abuse Negl
JT  - Child abuse & neglect
JID - 7801702
SB  - IM
MH  - Child
MH  - Confidentiality/*ethics
MH  - Congresses as Topic/*ethics
MH  - *Ethics, Research
MH  - Humans
MH  - Information Dissemination/*ethics
MH  - Informed Consent
MH  - Patient Advocacy
MH  - Vulnerable Populations
EDAT- 2012/11/14 06:00
MHDA- 2013/05/15 06:00
CRDT- 2012/11/14 06:00
PHST- 2012/04/16 00:00 [received]
PHST- 2012/07/30 00:00 [revised]
PHST- 2012/08/02 00:00 [accepted]
PHST- 2012/11/14 06:00 [entrez]
PHST- 2012/11/14 06:00 [pubmed]
PHST- 2013/05/15 06:00 [medline]
AID - S0145-2134(12)00191-3 [pii]
AID - 10.1016/j.chiabu.2012.08.001 [doi]
PST - ppublish
SO  - Child Abuse Negl. 2012 Nov-Dec;36(11-12):798-9. doi:
      10.1016/j.chiabu.2012.08.001. Epub 2012 Nov 10.


PMID- 23146123
OWN - NLM
STAT- MEDLINE
DCOM- 20130613
LR  - 20130111
IS  - 1651-2227 (Electronic)
IS  - 0803-5253 (Linking)
VI  - 102
IP  - 2
DP  - 2013 Feb
TI  - The politics of probiotics: probiotics, necrotizing enterocolitis and the ethics 
      of neonatal research.
PG  - 116-8
LID - 10.1111/apa.12083 [doi]
FAU - Janvier, Annie
AU  - Janvier A
AD  - Sainte Justine University Health Center, Montreal, QC, Canada.
      annie.janvier.hsj@ssss.gouv.qc.ca
FAU - Lantos, John
AU  - Lantos J
FAU - Barrington, Keith
AU  - Barrington K
LA  - eng
PT  - Journal Article
DEP - 20121215
PL  - Norway
TA  - Acta Paediatr
JT  - Acta paediatrica (Oslo, Norway : 1992)
JID - 9205968
SB  - IM
MH  - Drug and Narcotic Control
MH  - Enterocolitis, Necrotizing/*prevention & control
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Premature, Diseases/*prevention & control
MH  - *Politics
MH  - Probiotics/economics/*therapeutic use
MH  - Randomized Controlled Trials as Topic/*ethics
MH  - United States
EDAT- 2012/11/14 06:00
MHDA- 2013/06/14 06:00
CRDT- 2012/11/14 06:00
PHST- 2012/10/29 00:00 [received]
PHST- 2012/11/06 00:00 [accepted]
PHST- 2012/11/14 06:00 [entrez]
PHST- 2012/11/14 06:00 [pubmed]
PHST- 2013/06/14 06:00 [medline]
AID - 10.1111/apa.12083 [doi]
PST - ppublish
SO  - Acta Paediatr. 2013 Feb;102(2):116-8. doi: 10.1111/apa.12083. Epub 2012 Dec 15.


PMID- 23146078
OWN - NLM
STAT- MEDLINE
DCOM- 20140205
LR  - 20130527
IS  - 1466-187X (Electronic)
IS  - 0142-159X (Linking)
VI  - 35
IP  - 6
DP  - 2013 Jun
TI  - Academic dishonesty and ethical reasoning: pharmacy and medical school students
      in New Zealand.
PG  - e1211-7
LID - 10.3109/0142159X.2012.737962 [doi]
AB  - BACKGROUND: There is ample evidence to suggest that academic dishonesty remains
      an area of concern and interest for academic and professional bodies. There is
      also burgeoning research in the area of moral reasoning and its relevance to the 
      teaching of pharmacy and medicine. AIMS: To explore the associations between
      self-reported incidence of academic dishonesty and ethical reasoning in a
      professional student body. METHODS: Responses were elicited from 433 pharmacy and
      medicine students. A questionnaire eliciting responses about academic dishonesty 
      (copying, cheating, and collusion) and their decisions regarding an ethical
      dilemma was distributed. Multivariate analysis procedures were conducted.
      RESULTS: The findings suggested that copying and collusion may be linked to the
      way students make ethical decisions. Students more likely to suggest unlawful
      solutions to the ethical dilemma were more likely to disclose engagement in
      copying information and colluding with other students. CONCLUSIONS: These
      findings imply that students engaging in academic dishonesty may be using
      different ethical frameworks. Therefore, employing ethical dilemmas would likely 
      create a useful learning framework for identifying students employing dishonest
      strategies when coping with their studies. Increasing understanding through
      dialog about engagement in academic honesty will likely construct positive
      learning outcomes in the university with implications for future practice.
FAU - Henning, Marcus A
AU  - Henning MA
AD  - Centre for Medical and Health Sciences Education, University of Auckland,
      Auckland 1142, New Zealand. m.henning@auckland.ac.nz
FAU - Ram, Sanya
AU  - Ram S
FAU - Malpas, Phillipa
AU  - Malpas P
FAU - Shulruf, Boaz
AU  - Shulruf B
FAU - Kelly, Fiona
AU  - Kelly F
FAU - Hawken, Susan J
AU  - Hawken SJ
LA  - eng
PT  - Journal Article
DEP - 20121112
PL  - England
TA  - Med Teach
JT  - Medical teacher
JID - 7909593
SB  - IM
MH  - Adaptation, Psychological/ethics
MH  - Adolescent
MH  - Adult
MH  - *Deception
MH  - Education, Medical, Undergraduate/ethics
MH  - Education, Pharmacy/ethics
MH  - Female
MH  - Humans
MH  - Male
MH  - New Zealand
MH  - Problem Solving/*ethics
MH  - Self Report
MH  - Students, Medical/*psychology
MH  - Students, Pharmacy/*psychology
MH  - Young Adult
EDAT- 2012/11/14 06:00
MHDA- 2014/02/06 06:00
CRDT- 2012/11/14 06:00
PHST- 2012/11/14 06:00 [entrez]
PHST- 2012/11/14 06:00 [pubmed]
PHST- 2014/02/06 06:00 [medline]
AID - 10.3109/0142159X.2012.737962 [doi]
PST - ppublish
SO  - Med Teach. 2013 Jun;35(6):e1211-7. doi: 10.3109/0142159X.2012.737962. Epub 2012
      Nov 12.


PMID- 23146071
OWN - NLM
STAT- MEDLINE
DCOM- 20130528
LR  - 20211021
IS  - 1471-2458 (Electronic)
IS  - 1471-2458 (Linking)
VI  - 12
DP  - 2012 Nov 12
TI  - Home-based HIV counseling and testing: client experiences and perceptions in
      Eastern Uganda.
PG  - 966
LID - 10.1186/1471-2458-12-966 [doi]
AB  - BACKGROUND: Though prevention and treatment depend on individuals knowing their
      HIV status, the uptake of testing remains low in Sub-Saharan Africa. One
      initiative to encourage HIV testing involves delivering services at home.
      However, doubts have been cast about the ability of Home-Based HIV Counseling and
      Testing (HBHCT) to adhere to ethical practices including consent,
      confidentiality, and access to HIV care post-test. This study explored client
      experiences in relation these ethical issues. METHODS: We conducted 395
      individual interviews in Kumi district, Uganda, where teams providing HBHCT had
      visited 6-12 months prior to the interviews. Semi-structured questionnaires
      elicited information on clients' experiences, from initial community mobilization
      up to receipt of results and access to HIV services post-test. RESULTS: We found 
      that 95% of our respondents had ever tested (average for Uganda was 38%). Among
      those who were approached by HBHCT providers, 98% were informed of their right to
      decline HIV testing. Most respondents were counseled individually, but 69% of the
      married/cohabiting were counseled as couples. The majority of respondents (94%)
      were satisfied with the information given to them and the interaction with the
      HBHCT providers. Most respondents considered their own homes as more private than
      health facilities. Twelve respondents reported that they tested positive, 11 were
      referred for follow-up care, seven actually went for care, and only 5 knew their 
      CD4 counts. All HIV infected individuals who were married or cohabiting had
      disclosed their status to their partners. CONCLUSION: These findings show a very 
      high uptake of HIV testing and satisfaction with HBHCT, a large proportion of
      married respondents tested as couples, and high disclosure rates. HBHCT can play 
      a major role in expanding access to testing and overcoming disclosure challenges.
      However, access to HIV services post-test may require attention.
FAU - Kyaddondo, David
AU  - Kyaddondo D
AD  - Department of Social Work/Child Health and Development Centre, Makerere
      University, Kampala, Uganda. kyaddondo@hotmail.com
FAU - Wanyenze, Rhoda K
AU  - Wanyenze RK
FAU - Kinsman, John
AU  - Kinsman J
FAU - Hardon, Anita
AU  - Hardon A
LA  - eng
GR  - 5 R01 HD053268-05/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20121112
PL  - England
TA  - BMC Public Health
JT  - BMC public health
JID - 100968562
SB  - IM
MH  - Adult
MH  - Confidentiality/ethics
MH  - Directive Counseling/*methods
MH  - Female
MH  - HIV Infections/*diagnosis
MH  - Health Services Accessibility/ethics
MH  - Health Services Research
MH  - *Home Care Services/ethics
MH  - Humans
MH  - Informed Consent/ethics
MH  - Male
MH  - Patient Satisfaction/*statistics & numerical data
MH  - Qualitative Research
MH  - Referral and Consultation/statistics & numerical data
MH  - Surveys and Questionnaires
MH  - Truth Disclosure
MH  - Uganda
PMC - PMC3607982
EDAT- 2012/11/14 06:00
MHDA- 2013/05/29 06:00
CRDT- 2012/11/14 06:00
PHST- 2012/08/07 00:00 [received]
PHST- 2012/10/29 00:00 [accepted]
PHST- 2012/11/14 06:00 [entrez]
PHST- 2012/11/14 06:00 [pubmed]
PHST- 2013/05/29 06:00 [medline]
AID - 1471-2458-12-966 [pii]
AID - 10.1186/1471-2458-12-966 [doi]
PST - epublish
SO  - BMC Public Health. 2012 Nov 12;12:966. doi: 10.1186/1471-2458-12-966.


PMID- 23145517
OWN - NLM
STAT- MEDLINE
DCOM- 20131113
LR  - 20121113
IS  - 1365-2702 (Electronic)
IS  - 0962-1067 (Linking)
VI  - 21
IP  - 23-24
DP  - 2012 Dec
TI  - The effectiveness of simulation activities on the cognitive abilities of
      undergraduate third-year nursing students: a randomised control trial.
PG  - 3475-84
LID - 10.1111/j.1365-2702.2012.04257.x [doi]
AB  - AIMS AND OBJECTIVES: To provide evidence on the effectiveness of simulation
      activities on the clinical decision-making abilities of undergraduate nursing
      students. Based on previous research, it was hypothesised that the higher the
      cognitive score, the greater the ability a nursing student would have to make
      informed valid decisions in their clinical practice. BACKGROUND: Globally,
      simulation is being espoused as an education method that increases the competence
      of health professionals. At present, there is very little evidence to support
      current investment in time and resources. METHODS: Following ethical approval,
      fifty-eight third-year undergraduate nursing students were randomised in a
      pretest-post-test group-parallel controlled trial. The learning environment
      preferences (LEP) inventory was used to test cognitive abilities in order to
      refute the null hypothesis that activities in computer-based simulated learning
      environments have a negative effect on cognitive abilities when compared with
      activities in skills laboratory simulated learning environments. RESULTS: There
      was no significant difference in cognitive development following two cycles of
      simulation activities. Therefore, it is reasonable to assume that two simulation 
      tasks, either computer-based or laboratory-based, have no effect on an
      undergraduate student's ability to make clinical decisions in practice. However, 
      there was a significant finding for non-English first-language students, which
      requires further investigation. CONCLUSIONS: More longitudinal studies that
      quantify the education effects of simulation on the cognitive, affective and
      psychomotor attributes of health science students and professionals from both
      English-speaking and non-English-speaking backgrounds are urgently required. It
      is also recommended that to achieve increased participant numbers and prevent
      non-participation owing to absenteeism, further studies need to be imbedded
      directly into curricula. RELEVANCE TO CLINICAL PRACTICE: This investigation
      confirms the effect of simulation activities on real-life clinical practice, and 
      the comparative learning benefits with traditional clinical practice and
      university education remain unknown.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Secomb, Jacinta
AU  - Secomb J
AD  - Monash University, Clayton, Victoria, Australia. jmsecomb@tpg.com.au
FAU - McKenna, Lisa
AU  - McKenna L
FAU - Smith, Colleen
AU  - Smith C
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - J Clin Nurs
JT  - Journal of clinical nursing
JID - 9207302
MH  - *Cognition
MH  - Education, Nursing
MH  - Humans
MH  - Students, Nursing/*psychology
EDAT- 2012/11/14 06:00
MHDA- 2013/11/14 06:00
CRDT- 2012/11/14 06:00
PHST- 2012/11/14 06:00 [entrez]
PHST- 2012/11/14 06:00 [pubmed]
PHST- 2013/11/14 06:00 [medline]
AID - 10.1111/j.1365-2702.2012.04257.x [doi]
PST - ppublish
SO  - J Clin Nurs. 2012 Dec;21(23-24):3475-84. doi: 10.1111/j.1365-2702.2012.04257.x.


PMID- 23145514
OWN - NLM
STAT- MEDLINE
DCOM- 20131113
LR  - 20121113
IS  - 1365-2702 (Electronic)
IS  - 0962-1067 (Linking)
VI  - 21
IP  - 23-24
DP  - 2012 Dec
TI  - What is missed in self-immolated patients' care? A grounded theory study.
PG  - 3418-28
LID - 10.1111/jocn.12006 [doi]
AB  - AIMS AND OBJECTIVES: To explore rehabilitation care process in patients who
      commit self-immolation. BACKGROUND: Self-immolation is not only a type of burn
      injury, but it is also a suicidal method. It is placed in burn injury category
      that requires long-term rehabilitation and treatment measures. As a suicidal
      method, among all forms of suicidal attempts, it is the most dramatic, violent
      and often difficult one to understand. Unfortunately, there are few reported
      studies investigating experiences and perceptions of nurses about burn care and
      with qualitative study about the patients' experiences and perceptions. DESIGN:
      On the basis of the research question, the grounded theory method was used.
      METHODS: Considering ethical codes of Belmont and Helsinki statements, purposive 
      sampling was used to select the participants. The patients were deliberately
      selected, based on the research needs. They were self-immolated patients being
      referred to Talaghani hospital of Ilam (western Iran) or discharged previously
      (time of interview and observation ranged from immediately later the burn till 5 
      years after), in Ilam, where self-immolation rate is very high. The main methods 
      for data collection were deep, open ended, semi-structured interviews, dairies
      and observations. The interviews were audio taped in Persian, and verbatim
      transcriptions were made. By doing so, semantic meaning is preserved, and
      misinterpretation of data due to translation into English is minimised. Data
      analysis was conducted using the Strauss and Corbin method. RESULTS: Five main
      categories were emerged: situation of crisis unprofessional care, prolongation
      and formidability of the journey, self-immolation as paralyse, and attempt for
      self-management. Finally, by constant, comparison of collected data and emerged
      categories, central variable entitled unintegrated care emerged as the main
      problem of self-immolated patients' care. CONCLUSION: The study comes to the
      conclusion that we need to focus on specific considerations to provide integrated
      care for the burned patients as it is a decisive component of care that is
      missed. RELEVANCE TO CLINICAL PRACTICE: Although self-immolation requires
      long-term treatment and social, emotional rehabilitation, such a rehabilitation
      care process is not clear.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Norouzi, Kian
AU  - Norouzi K
AD  - Department of Nursing, University of Social Welfare and Rehabilitation Sciences, 
      Tehran.
FAU - Taghinejad, Hamid
AU  - Taghinejad H
FAU - Mohammadi, Farahnaz
AU  - Mohammadi F
FAU - Mohammadi, Eesa
AU  - Mohammadi E
FAU - Suhrabi, Zainab
AU  - Suhrabi Z
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Clin Nurs
JT  - Journal of clinical nursing
JID - 9207302
MH  - Adolescent
MH  - Adult
MH  - Burns/psychology/*therapy
MH  - Female
MH  - Humans
MH  - Iran
MH  - Male
MH  - Middle Aged
MH  - *Models, Theoretical
MH  - Self-Injurious Behavior/psychology/*rehabilitation
MH  - Suicide, Attempted
MH  - Young Adult
EDAT- 2012/11/14 06:00
MHDA- 2013/11/14 06:00
CRDT- 2012/11/14 06:00
PHST- 2012/11/14 06:00 [entrez]
PHST- 2012/11/14 06:00 [pubmed]
PHST- 2013/11/14 06:00 [medline]
AID - 10.1111/jocn.12006 [doi]
PST - ppublish
SO  - J Clin Nurs. 2012 Dec;21(23-24):3418-28. doi: 10.1111/jocn.12006.


PMID- 23145015
OWN - NLM
STAT- MEDLINE
DCOM- 20130523
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 11
DP  - 2012
TI  - Harmonization of the practice of independent ethics committees in Italy: project 
      E-submission.
PG  - e48906
LID - 10.1371/journal.pone.0048906 [doi]
AB  - AIM: The high variability of "centre-specific" documentation required by
      Independent Ethics Committee (IEC) plays a role in the time required for
      activation of participating centres of multicentre clinical trials. This study
      (a) provides a picture of the different activities, structural requirements and
      resources dedicated to the operation of the local IEC in Italy; (b) defines a
      detailed list of "centre-specific" documents considered as essential by the IEC
      for issuing its opinion and (c) suggests a "single document" to reduce the
      variability of the "centre-specific" documents required by the IEC. METHODOLOGY: 
      Two surveys were conducted through the portal of National Monitoring Centre of
      Clinical Trials (https://oss-sper-clin.agenziafarmaco.it/). The first survey
      focused on the local IEC resources and on the "centre-specific" documentation
      that local IEC required from the Sponsor and local Principal Investigator (PI).
      The second focused on "single document" required in the form of statements from
      the Sponsor and the PI. Answers were discussed and extended during regular
      scheduled teleconferences and plenary meeting. PRINCIPAL FINDINGS: From
      22/07/2009 to 15/12/2009, and from 19/04/2010 to 14/05/2010, 131 and 125 IECs
      responded to the first and the second surveys, respectively. 67% and 51% of IECs 
      consider the structural requirements and the staff dedicated to the activity of
      the IECs as sufficient, respectively. Most of the IECs consider the
      "centre-specific" documentation as necessary for issuing the opinion, and a high 
      percentage of IECs consider the proposed documentation as acceptable in
      substitution to any other "centre-specific" documentation already in use.
      CONCLUSIONS: The harmonization of IECs practice in Italy is the first step to
      facilitate multicentre clinical trials. Similar efforts should be directed to
      reduce the total number of IECs and to standardize clinical trials approval
      procedures, focusing on administrative procedures as well.
FAU - De Feo, Gianfranco
AU  - De Feo G
AD  - National Cancer Institute, Naples, Italy. g.defeo@istitutotumori.na.it
FAU - Chiabrando, Giacomo
AU  - Chiabrando G
FAU - Cannovo, Nunzia
AU  - Cannovo N
FAU - Galluccio, Antonio
AU  - Galluccio A
FAU - Tomino, Carlo
AU  - Tomino C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121107
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Clinical Trials as Topic/standards
MH  - Documentation
MH  - Ethics Committees, Research/*standards
MH  - Italy
MH  - Multicenter Studies as Topic/standards
PMC - PMC3492143
EDAT- 2012/11/13 06:00
MHDA- 2013/05/25 06:00
CRDT- 2012/11/13 06:00
PHST- 2012/06/28 00:00 [received]
PHST- 2012/10/02 00:00 [accepted]
PHST- 2012/11/13 06:00 [entrez]
PHST- 2012/11/13 06:00 [pubmed]
PHST- 2013/05/25 06:00 [medline]
AID - 10.1371/journal.pone.0048906 [doi]
AID - PONE-D-12-19562 [pii]
PST - ppublish
SO  - PLoS One. 2012;7(11):e48906. doi: 10.1371/journal.pone.0048906. Epub 2012 Nov 7.


PMID- 23144936
OWN - NLM
STAT- MEDLINE
DCOM- 20130509
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 11
DP  - 2012
TI  - Different levels of food restriction reveal genotype-specific differences in
      learning a visual discrimination task.
PG  - e48703
LID - 10.1371/journal.pone.0048703 [doi]
AB  - In behavioural experiments, motivation to learn can be achieved using food
      rewards as positive reinforcement in food-restricted animals. Previous studies
      reduce animal weights to 80-90% of free-feeding body weight as the criterion for 
      food restriction. However, effects of different degrees of food restriction on
      task performance have not been assessed. We compared learning task performance in
      mice food-restricted to 80 or 90% body weight (BW). We used adult wildtype (WT;
      C57Bl/6j) and knockout (ephrin-A2(-)/(-)) mice, previously shown to have a
      reverse learning deficit. Mice were trained in a two-choice visual discrimination
      task with food reward as positive reinforcement. When mice reached criterion for 
      one visual stimulus (80% correct in three consecutive 10 trial sets) they began
      the reverse learning phase, where the rewarded stimulus was switched to the
      previously incorrect stimulus. For the initial learning and reverse phase of the 
      task, mice at 90%BW took almost twice as many trials to reach criterion as mice
      at 80%BW. Furthermore, WT 80 and 90%BW groups significantly differed in
      percentage correct responses and learning strategy in the reverse learning phase,
      whereas no differences between weight restriction groups were observed in
      ephrin-A2(-)/(-) mice. Most importantly, genotype-specific differences in reverse
      learning strategy were only detected in the 80%BW groups. Our results indicate
      that increased food restriction not only results in better performance and a
      shorter training period, but may also be necessary for revealing behavioural
      differences between experimental groups. This has important ethical and animal
      welfare implications when deciding extent of diet restriction in behavioural
      studies.
FAU - Makowiecki, Kalina
AU  - Makowiecki K
AD  - School of Animal Biology, The University of Western Australia, Crawley, Western
      Australia, Australia.
FAU - Hammond, Geoff
AU  - Hammond G
FAU - Rodger, Jennifer
AU  - Rodger J
LA  - eng
PT  - Journal Article
DEP - 20121107
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Ephrin-A2)
SB  - IM
MH  - Animals
MH  - Behavior, Animal
MH  - Diet
MH  - Discrimination, Psychological/*physiology
MH  - Ephrin-A2/genetics
MH  - *Genotype
MH  - Learning/*physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Reinforcement, Psychology
MH  - Stress, Psychological/*genetics
PMC - PMC3492417
EDAT- 2012/11/13 06:00
MHDA- 2013/05/10 06:00
CRDT- 2012/11/13 06:00
PHST- 2012/09/19 00:00 [received]
PHST- 2012/10/03 00:00 [accepted]
PHST- 2012/11/13 06:00 [entrez]
PHST- 2012/11/13 06:00 [pubmed]
PHST- 2013/05/10 06:00 [medline]
AID - 10.1371/journal.pone.0048703 [doi]
AID - PONE-D-12-28852 [pii]
PST - ppublish
SO  - PLoS One. 2012;7(11):e48703. doi: 10.1371/journal.pone.0048703. Epub 2012 Nov 7.


PMID- 23144475
OWN - NLM
STAT- MEDLINE
DCOM- 20130211
LR  - 20121112
IS  - 1930-7837 (Electronic)
IS  - 0022-0337 (Linking)
VI  - 76
IP  - 11
DP  - 2012 Nov
TI  - The summer institute in clinical dental research methods: still going and growing
      after twenty years.
PG  - 1408-15
AB  - The first Summer Institute in Clinical Dental Research Methods, a faculty
      development program at the University of Washington, was offered in the summer of
      1992 for sixteen participants. The primary objective of the program was to give
      clinical faculty members in dentistry an introduction to and an understanding of 
      the fundamental principles and methods used in good clinical research. In the
      twentieth offering of the institute in 2011, there were thirty-five participants,
      and over the twenty institutes, there has been a cumulative total of 463
      participants who have come from thirty U.S. states as well as forty-three
      countries outside the United States. The curriculum has expanded from the initial
      offering of biostatistics, clinical epidemiology, behavioral research methods,
      and ethics in clinical research to now include clinical trials, grantsmanship,
      data analysis, an elective in molecular biology, and a team project that provides
      participants with hands-on experience in research proposal development as members
      of an interdisciplinary team. Enrollment has doubled since the first year, yet
      exit evaluations of the program content have remained consistently high (rated as
      very good to excellent). One of the indicators of program quality is that at
      least 50 percent of recent participants indicated that they attended because the 
      program was recommended by colleagues who had attended. There seems to be an
      ever-increasing pool of dental faculty members who are eager to learn more about 
      clinical research methodology through the institute despite the intensive demands
      of full-time participation in a six-week program.
FAU - Derouen, Timothy A
AU  - Derouen TA
AD  - University of Washington, School of Dentistry, Box 357475, Seattle, WA 98195,
      USA. derouen@uw.edu
FAU - Wiesenbach, Carol
AU  - Wiesenbach C
LA  - eng
GR  - P30 DE009743/DE/NIDCR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Dent Educ
JT  - Journal of dental education
JID - 8000150
SB  - IM
MH  - Behavioral Sciences/education
MH  - Biostatistics
MH  - Clinical Trials as Topic
MH  - Curriculum
MH  - Dental Research/*education
MH  - Epidemiology/education
MH  - Ethics, Research/education
MH  - *Faculty, Dental
MH  - Humans
MH  - Molecular Biology/education
MH  - Motivation
MH  - Professional Competence
MH  - Program Development
MH  - Program Evaluation
MH  - Research Design
MH  - Research Support as Topic
MH  - Staff Development/*methods
MH  - Statistics as Topic/education
MH  - Washington
EDAT- 2012/11/13 06:00
MHDA- 2013/02/12 06:00
CRDT- 2012/11/13 06:00
PHST- 2012/11/13 06:00 [entrez]
PHST- 2012/11/13 06:00 [pubmed]
PHST- 2013/02/12 06:00 [medline]
AID - 76/11/1408 [pii]
PST - ppublish
SO  - J Dent Educ. 2012 Nov;76(11):1408-15.


PMID- 23144015
OWN - NLM
STAT- MEDLINE
DCOM- 20130325
LR  - 20130121
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 2
DP  - 2013 Feb
TI  - Translation and cross-cultural adaptation of a family booklet on comfort care in 
      dementia: sensitive topics revised before implementation.
PG  - 104-9
LID - 10.1136/medethics-2012-100903 [doi]
AB  - INTRODUCTION: Families of patients with dementia may need support in difficult
      end-of-life decision making. Such guidance may be culturally sensitive. METHODS: 
      To support families in Canada, a booklet was developed to aid decision making on 
      palliative care issues. For reasons of cost effectiveness and promising effects, 
      we prepared for its implementation in Italy, the Netherlands and Japan. Local
      teams translated and adapted the booklet to local ethical, legal and medical
      standards where needed, retaining guidance on palliative care. Using qualitative 
      content analyses, we grouped and compared adaptations to understand culturally
      sensitive aspects. RESULTS: Three themes emerged: (1) relationships among
      patient, physician and other professionals-the authority of the physician was
      more explicit in adapted versions; (2) patient rights and family position-adding 
      detail about local regulations; and (3) typology of treatments and decisions.
      Considerations underlying palliative care decisions were detailed (Dutch and
      Italian versions), and the Japanese version frequently referred to professional
      and legal standards, and life-prolongation was a competing goal. Text on
      artificial feeding or fluids and euthanasia was revised extensively. CONCLUSIONS:
      Providing artificial feeding and fluids and discussing euthanasia may be
      particularly sensitive topics, and guidance on these subjects needs careful
      consideration of ethical aspects and possible adaptations to local standards and 
      practice. The findings may promote cross-national debate on sensitive, core
      issues regarding end-of-life care in dementia.
FAU - van der Steen, Jenny T
AU  - van der Steen JT
AD  - Department of general practice & elderly care medicine, VU University Medical
      Center, EMGO Institute for Health and Care Research, Amsterdam, The Netherlands. 
      j.vandersteen@vumc.nl
FAU - Hertogh, Cees M P M
AU  - Hertogh CM
FAU - de Graas, Tjomme
AU  - de Graas T
FAU - Nakanishi, Miharu
AU  - Nakanishi M
FAU - Toscani, Franco
AU  - Toscani F
FAU - Arcand, Marcel
AU  - Arcand M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121110
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Canada
MH  - *Cultural Characteristics
MH  - Decision Making
MH  - *Dementia
MH  - *Family
MH  - Fluid Therapy/ethics
MH  - Humans
MH  - International Cooperation
MH  - Interpersonal Relations
MH  - Italy
MH  - Japan
MH  - Netherlands
MH  - Nutritional Support/ethics
MH  - *Palliative Care/ethics
MH  - *Pamphlets
MH  - Patient Rights/ethics
MH  - Physician's Role
MH  - Qualitative Research
MH  - *Terminal Care/ethics
MH  - *Translations
EDAT- 2012/11/13 06:00
MHDA- 2013/03/26 06:00
CRDT- 2012/11/13 06:00
PHST- 2012/11/13 06:00 [entrez]
PHST- 2012/11/13 06:00 [pubmed]
PHST- 2013/03/26 06:00 [medline]
AID - medethics-2012-100903 [pii]
AID - 10.1136/medethics-2012-100903 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Feb;39(2):104-9. doi: 10.1136/medethics-2012-100903. Epub 2012
      Nov 10.


PMID- 23143838
OWN - NLM
STAT- MEDLINE
DCOM- 20140122
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 3
DP  - 2013 Sep
TI  - Case-based ethics instruction: the influence of contextual and individual factors
      in case content on ethical decision-making.
PG  - 1305-22
LID - 10.1007/s11948-012-9414-3 [doi]
AB  - Cases have been employed across multiple disciplines, including ethics education,
      as effective pedagogical tools. However, the benefit of case-based learning in
      the ethics domain varies across cases, suggesting that not all cases are equal in
      terms of pedagogical value. Indeed, case content appears to influence the extent 
      to which cases promote learning and transfer. Consistent with this argument, the 
      current study explored the influences of contextual and personal factors embedded
      in case content on ethical decision-making. Cases were manipulated to include a
      clear description of the social context and the goals of the characters involved.
      Results indicated that social context, specifically the description of an
      autonomy-supportive environment, facilitated execution of sense making processes 
      and resulted in greater decision ethicality. Implications for designing optimal
      cases and case-based training programs are discussed.
FAU - Bagdasarov, Zhanna
AU  - Bagdasarov Z
AD  - Department of Psychology, University of Oklahoma, Norman, OK 73019, USA.
      zhannab@ou.edu
FAU - Thiel, Chase E
AU  - Thiel CE
FAU - Johnson, James F
AU  - Johnson JF
FAU - Connelly, Shane
AU  - Connelly S
FAU - Harkrider, Lauren N
AU  - Harkrider LN
FAU - Devenport, Lynn D
AU  - Devenport LD
FAU - Mumford, Michael D
AU  - Mumford MD
LA  - eng
PT  - Journal Article
DEP - 20121110
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Adult
MH  - Curriculum
MH  - Decision Making/*ethics
MH  - Ethics, Professional/*education
MH  - Ethics, Research/*education
MH  - Female
MH  - Humans
MH  - Male
MH  - *Personal Autonomy
MH  - Problem-Based Learning/*methods
MH  - *Social Environment
MH  - Teaching/*methods
MH  - Young Adult
EDAT- 2012/11/13 06:00
MHDA- 2014/01/23 06:00
CRDT- 2012/11/13 06:00
PHST- 2012/08/25 00:00 [received]
PHST- 2012/11/04 00:00 [accepted]
PHST- 2012/11/13 06:00 [entrez]
PHST- 2012/11/13 06:00 [pubmed]
PHST- 2014/01/23 06:00 [medline]
AID - 10.1007/s11948-012-9414-3 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Sep;19(3):1305-22. doi: 10.1007/s11948-012-9414-3. Epub 2012
      Nov 10.


PMID- 23143447
OWN - NLM
STAT- MEDLINE
DCOM- 20130207
LR  - 20181202
IS  - 1538-3601 (Electronic)
IS  - 0003-9950 (Linking)
VI  - 130
IP  - 11
DP  - 2012 Nov
TI  - Carl B. Camras, MD: reflections on his contributions to glaucoma research and
      clinical practice.
PG  - 1456-60
LID - 10.1001/archophthalmol.2012.1839 [doi]
AB  - My husband, Carl B. Camras, MD (chairman of the Department of Ophthalmology and
      Visual Sciences, University of Nebraska Medical Center, Omaha), died at age 55
      years in 2009. His dying wish was to be remembered for being the first to
      hypothesize that prostaglandins lower intraocular pressure and had potential as a
      medication to treat glaucoma. I reviewed the research he performed as an
      undergraduate at Yale University (New Haven, Connecticut), as a medical student
      at Columbia University (New York, New York), and on the faculty at Mount Sinai
      School of Medicine (New York, New York), which confirmed his hypothesis and led
      to the development of latanoprost. This article summarizes his contributions to
      glaucoma research, his role in the development of latanoprost, and the error of
      omission that prevented his recognition as its coinventor. Carl is best
      remembered as an ethical scientist, a gifted clinician, and a beloved teacher,
      who inspired the medical community and the next generation of ophthalmologists.
FAU - Camras, Nancy L
AU  - Camras NL
AD  - weatheringhghts@msn.com
LA  - eng
PT  - Biography
PT  - Historical Article
PL  - United States
TA  - Arch Ophthalmol
JT  - Archives of ophthalmology (Chicago, Ill. : 1960)
JID - 7706534
RN  - 0 (Prostaglandins F, Synthetic)
RN  - 6Z5B6HVF6O (Latanoprost)
SB  - IM
MH  - Biomedical Research/*history
MH  - Glaucoma/*history
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Latanoprost
MH  - Ophthalmology/*history
MH  - Prostaglandins F, Synthetic/history
MH  - United States
PS  - Camras CB
FPS - Camras, Carl B
EDAT- 2012/11/13 06:00
MHDA- 2013/02/08 06:00
CRDT- 2012/11/13 06:00
PHST- 2012/11/13 06:00 [entrez]
PHST- 2012/11/13 06:00 [pubmed]
PHST- 2013/02/08 06:00 [medline]
AID - 1390047 [pii]
AID - 10.1001/archophthalmol.2012.1839 [doi]
PST - ppublish
SO  - Arch Ophthalmol. 2012 Nov;130(11):1456-60. doi: 10.1001/archophthalmol.2012.1839.


PMID- 23143388
OWN - NLM
STAT- MEDLINE
DCOM- 20140220
LR  - 20211021
IS  - 1433-7347 (Electronic)
IS  - 0942-2056 (Linking)
VI  - 21
IP  - 7
DP  - 2013 Jul
TI  - Consideration of religious sentiments while selecting a biological product for
      knee arthroscopy.
PG  - 1577-86
LID - 10.1007/s00167-012-2292-z [doi]
AB  - PURPOSE: There is an increasing use of various synthetic and biological products 
      in orthopaedics. The use of a biological product can be a major area of concern
      for patients of various cultures/religions. The purpose of this work is to study 
      various restrictions in different faiths and their compatibility with available
      products focused on cartilage repair. METHODS: A systematic search in several
      databases, CINAHL, EMBASE, Global health, PubMed, MEDLINE and the Cochrane
      collaboration, was performed to find out various religious beliefs of some major 
      religions regarding the use of animal products. Hindu, Muslim, Christian, Jewish 
      and Buddhist faiths were studied to find out whether animal-derived surgical
      implants are permitted. Major religious scholars were asked about their opinions,
      and guidelines related to human/religious ethics were evaluated. A market survey 
      was carried out to find out biological contents of various products and their
      compatibility. RESULTS: Jews and Muslims have religious restrictions for porcine 
      products, while Hindus reject bovine products. Vegetarian Hindus reject usage of 
      any animal product. Most Christians do not have any restrictions except those who
      follow vegetarian dietary regulations. Though there is no prohibition for the use
      of animal products in Buddhism, a code of non-violence to animals is being
      followed. However, difference of opinion exists about interpretation of these
      dietary guidelines for surgical usage amongst various scholars. CONCLUSION:
      Products of biological origin have a definite restriction for various religions, 
      with few exceptions. Surgeons should know the source of the product and should be
      aware of the basic requirements of the patient's faith. Patient should be
      informed about the source of the product and alternative if available, and an
      informed consent may be considered. LEVEL OF EVIDENCE: Type of study, Level V.
FAU - Goyal, Deepak
AU  - Goyal D
AD  - Saumya Orthocare, Centre for Advanced Surgeries of the Knee Joint, Sabarmati,
      Ahmedabad 380005, India. deepak@knee.in
FAU - Goyal, Anjali
AU  - Goyal A
FAU - Brittberg, Mats
AU  - Brittberg M
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121110
PL  - Germany
TA  - Knee Surg Sports Traumatol Arthrosc
JT  - Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
JID - 9314730
RN  - 0 (Biological Products)
SB  - IM
MH  - Animals
MH  - *Biological Products
MH  - Buddhism
MH  - Christianity
MH  - Hinduism
MH  - Humans
MH  - Islam
MH  - Judaism
MH  - *Orthopedics
MH  - *Religion and Medicine
EDAT- 2012/11/13 06:00
MHDA- 2014/02/22 06:00
CRDT- 2012/11/13 06:00
PHST- 2012/06/06 00:00 [received]
PHST- 2012/10/29 00:00 [accepted]
PHST- 2012/11/13 06:00 [entrez]
PHST- 2012/11/13 06:00 [pubmed]
PHST- 2014/02/22 06:00 [medline]
AID - 10.1007/s00167-012-2292-z [doi]
PST - ppublish
SO  - Knee Surg Sports Traumatol Arthrosc. 2013 Jul;21(7):1577-86. doi:
      10.1007/s00167-012-2292-z. Epub 2012 Nov 10.


PMID- 23143142
OWN - NLM
STAT- MEDLINE
DCOM- 20140926
LR  - 20211021
IS  - 1435-604X (Electronic)
IS  - 0268-8921 (Linking)
VI  - 29
IP  - 1
DP  - 2014 Jan
TI  - Evaluation of low-level laser therapy effectiveness on the pain and masticatory
      performance of patients with myofascial pain.
PG  - 29-35
LID - 10.1007/s10103-012-1228-7 [doi]
AB  - This study investigated the effect of low-level laser therapy (LLLT) on the
      masticatory performance (MP), pressure pain threshold (PPT), and pain intensity
      in patients with myofascial pain. Twenty-one subjects, with myofascial pain
      according to Research Diagnostic Criteria/temporomandibular dysfunction, were
      divided into laser group (n = 12) and placebo group (n = 9) to receive laser
      therapy (active or placebo) two times per week for 4 weeks. The measured
      variables were: (1) MP by analysis of the geometric mean diameter (GMD) of the
      chewed particles using Optocal test material, (2) PPT by a pressure algometer,
      and (3) pain intensity by the visual analog scale (VAS). Measurements of MP and
      PPT were obtained at three time points: baseline, at the end of treatment with
      low-level laser and 30 days after (follow-up). VAS was measured at the same times
      as above and weekly throughout the laser therapy. The Friedman test was used at a
      significance level of 5% for data analysis. The study was approved by the Ethics 
      Committee of the Federal University of Sergipe (CAAE: 0025.0.107.000-10). A
      reduction in the GMD of crushed particles (p < 0.01) and an increase in PPT (p < 
      0.05) were seen only in the laser group when comparing the baseline and
      end-of-treatment values. Both groups showed a decrease in pain intensity at the
      end of treatment. LLLT promoted an improvement in MP and PPT of the masticatory
      muscles.
FAU - de Moraes Maia, Mila Leite
AU  - de Moraes Maia ML
AD  - Health Science Program, Federal University of Sergipe, Sergipe, Brazil.
FAU - Ribeiro, Maria Amalia Gonzaga
AU  - Ribeiro MA
FAU - Maia, Luiz Guilherme Martins
AU  - Maia LG
FAU - Stuginski-Barbosa, Juliana
AU  - Stuginski-Barbosa J
FAU - Costa, Yuri Martins
AU  - Costa YM
FAU - Porporatti, Andre Luis
AU  - Porporatti AL
FAU - Conti, Paulo Cesar Rodrigues
AU  - Conti PC
FAU - Bonjardim, Leonardo Rigoldi
AU  - Bonjardim LR
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20121110
PL  - England
TA  - Lasers Med Sci
JT  - Lasers in medical science
JID - 8611515
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Facial Pain/physiopathology/*radiotherapy
MH  - Female
MH  - Humans
MH  - Lasers, Semiconductor/*therapeutic use
MH  - *Low-Level Light Therapy
MH  - Male
MH  - Mastication/radiation effects
MH  - Masticatory Muscles/physiopathology/radiation effects
MH  - Pain Measurement
MH  - Pain Threshold/radiation effects
MH  - Temporomandibular Joint Disorders/physiopathology/radiotherapy
MH  - Young Adult
EDAT- 2012/11/13 06:00
MHDA- 2014/09/27 06:00
CRDT- 2012/11/13 06:00
PHST- 2012/09/12 00:00 [received]
PHST- 2012/10/29 00:00 [accepted]
PHST- 2012/11/13 06:00 [entrez]
PHST- 2012/11/13 06:00 [pubmed]
PHST- 2014/09/27 06:00 [medline]
AID - 10.1007/s10103-012-1228-7 [doi]
PST - ppublish
SO  - Lasers Med Sci. 2014 Jan;29(1):29-35. doi: 10.1007/s10103-012-1228-7. Epub 2012
      Nov 10.


PMID- 23143028
OWN - NLM
STAT- MEDLINE
DCOM- 20130405
LR  - 20140731
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 266
IP  - 2
DP  - 2013 Feb
TI  - Percutaneous recanalization for Budd-Chiari syndrome: an 11-year retrospective
      study on patency and survival in 177 Chinese patients from a single center.
PG  - 657-67
LID - 10.1148/radiol.12120856 [doi]
AB  - PURPOSE: To evaluate the long-term outcomes of percutaneous recanalization and
      determine the predictors of patency and survival in a large case series of
      Chinese patients with Budd-Chiari syndrome (BCS). MATERIALS AND METHODS: This
      retrospective study was approved by the institutional ethics committee. Informed 
      consent for the procedure was obtained from all patients. Between July 1999 and
      August 2010, 177 consecutive Chinese patients with primary BCS were treated with 
      percutaneous recanalization and followed up until death or their last clinical
      evaluation. Recanalization therapeutic strategy and complications were recorded. 
      Cumulative patency and survival rates were assessed with Kaplan-Meier curves.
      Independent predictors of patency and survival were calculated with the Cox
      regression model. RESULTS: Percutaneous recanalization was technically successful
      in 168 of the 177 patients (95%). Fifty-one of the 168 patients (30%) were
      treated with percutaneous transluminal angioplasty (PTA) alone and 117 (70%) were
      treated with a combination of PTA and stent placement. Procedure-related
      complications occurred in seven of the 168 patients (4%). The cumulative 1-, 5-, 
      and 10-year primary patency rates were 95%, 77%, and 58%, respectively.
      Independent predictors of reocclusion included increased white blood cell count
      and use of PTA alone. The cumulative 1-, 5-, and 10-year secondary patency rates 
      were 97%, 90%, and 86%, respectively. Twenty-two patients died during a median
      follow-up of 30 months (range, 0.25-137 months). The cumulative 1-, 5-, and
      10-year survival rates were 96%, 83%, and 73%, respectively. Independent
      predictors of survival included variceal bleeding, increased alkaline phosphatase
      and blood urea nitrogen levels, and reocclusion. CONCLUSION: Percutaneous
      recanalization could achieve excellent long-term patency and survival in most
      Chinese patients with BCS. PTA combined with stent placement should be
      recommended to decrease the frequency of reocclusion and its associated
      mortality.
FAU - Han, Guohong
AU  - Han G
AD  - Department of Digestive Interventional Radiology, Xijing Hospital of Digestive
      Diseases, Fourth Military Medical University, 15 West Changle Rd, Xi'an 710032,
      China. hangh@fmmu.edu.cn
FAU - Qi, Xingshun
AU  - Qi X
FAU - Zhang, Wei
AU  - Zhang W
FAU - He, Chuangye
AU  - He C
FAU - Yin, Zhanxin
AU  - Yin Z
FAU - Wang, Jianhong
AU  - Wang J
FAU - Xia, Jielai
AU  - Xia J
FAU - Xu, Ke
AU  - Xu K
FAU - Guo, Wengang
AU  - Guo W
FAU - Niu, Jing
AU  - Niu J
FAU - Wu, Kaichun
AU  - Wu K
FAU - Fan, Daiming
AU  - Fan D
LA  - eng
PT  - Journal Article
DEP - 20121109
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - *Angioplasty
MH  - Budd-Chiari Syndrome/diagnosis/epidemiology/*therapy
MH  - Chi-Square Distribution
MH  - China/epidemiology
MH  - Diagnostic Imaging
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Proportional Hazards Models
MH  - Retrospective Studies
MH  - Survival Rate
MH  - Treatment Outcome
MH  - Vascular Patency
EDAT- 2012/11/13 06:00
MHDA- 2013/04/06 06:00
CRDT- 2012/11/13 06:00
PHST- 2012/11/13 06:00 [entrez]
PHST- 2012/11/13 06:00 [pubmed]
PHST- 2013/04/06 06:00 [medline]
AID - radiol.12120856 [pii]
AID - 10.1148/radiol.12120856 [doi]
PST - ppublish
SO  - Radiology. 2013 Feb;266(2):657-67. doi: 10.1148/radiol.12120856. Epub 2012 Nov 9.


PMID- 23142405
OWN - NLM
STAT- MEDLINE
DCOM- 20131217
LR  - 20121211
IS  - 0375-0906 (Print)
IS  - 0375-0906 (Linking)
VI  - 77
IP  - 4
DP  - 2012 Oct-Dec
TI  - Association between medication use and adverse gastroenterologic events in
      patients receiving enteral nutrition therapy at a University Hospital.
PG  - 161-6
LID - 10.1016/j.rgmx.2012.06.003 [doi]
LID - S0375-0906(12)00111-5 [pii]
AB  - INTRODUCTION: Enteral Nutrition Therapy (ENT) is considered an important tool for
      the appropriate maintenance of nutritional conditions. ENT tolerance may be
      limited due to gastrointestinal (GI) events resulting from formula composition
      and/or simultaneously administered drug therapies. AIMS: To verify the possible
      association between GI events and drug therapies being administered to patients
      receiving ENT at a university hospital. METHODS: A prospective observational
      cohort study was conducted. Medical records from 95 patients requiring ENT at the
      Hospital de Clinicas de Porto Alegre (HCPA) were randomly evaluated until
      discharge, death, or initiation of oral or parenteral diet occurred. Details of
      the administered medications and enteral formula, together with the presenting
      patient disease and digestive manifestations, were recorded by the medical team. 
      Three experienced gastroenterologists evaluated the possible association between 
      the digestive symptoms and the medications employed. The study protocol was
      approved by the HCPA Research Ethics Committee and patient consent forms were
      signed. RESULTS: Mean patient age: 65+/-17 (24-95) years; 94.70% presented with
      GI events: constipation 70.50%, diarrhea 38.90%, abdominal distension 18.90%,
      vomiting 16.80%, and pulmonary aspiration 1.10%. ENT was most indicated in
      neurologic (50.50%) and neoplastic (25.30%) disease. Medications given to the
      patients showed a positive relation: 63.20% to 86.70% of GI symptoms could be
      attributed to the drugs being administered. CONCLUSIONS: GI complications during 
      ENT are common; they are frequently linked to administered drug therapy. Health
      care teams should consider all risk factors present, specifically those related
      to prescribed medication, before modifying/suspending ENT.
CI  - Copyright (c) 2012 Asociacion Mexicana de Gastroenterologia. Published by Masson 
      Doyma Mexico S.A. All rights reserved.
FAU - Catafesta, J
AU  - Catafesta J
AD  - Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
      jocicatafesta@yahoo.com.br
FAU - Francesconi, C
AU  - Francesconi C
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20121108
PL  - Mexico
TA  - Rev Gastroenterol Mex
JT  - Revista de gastroenterologia de Mexico
JID - 0404271
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cohort Studies
MH  - Data Interpretation, Statistical
MH  - *Drug-Related Side Effects and Adverse Reactions
MH  - Enteral Nutrition/*adverse effects
MH  - Female
MH  - Food, Formulated
MH  - Gastrointestinal Diseases/*chemically induced/epidemiology/*etiology
MH  - Hospitals, University
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2012/11/13 06:00
MHDA- 2013/12/18 06:00
CRDT- 2012/11/13 06:00
PHST- 2012/01/18 00:00 [received]
PHST- 2012/05/19 00:00 [revised]
PHST- 2012/06/28 00:00 [accepted]
PHST- 2012/11/13 06:00 [entrez]
PHST- 2012/11/13 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
AID - S0375-0906(12)00111-5 [pii]
AID - 10.1016/j.rgmx.2012.06.003 [doi]
PST - ppublish
SO  - Rev Gastroenterol Mex. 2012 Oct-Dec;77(4):161-6. doi: 10.1016/j.rgmx.2012.06.003.
      Epub 2012 Nov 8.


PMID- 23142173
OWN - NLM
STAT- MEDLINE
DCOM- 20151105
LR  - 20181202
IS  - 1532-2793 (Electronic)
IS  - 0260-6917 (Linking)
VI  - 33
IP  - 8
DP  - 2013 Aug
TI  - Personal change amongst mental health nursing students: a longitudinal study.
PG  - 860-5
LID - 10.1016/j.nedt.2012.10.006 [doi]
LID - S0260-6917(12)00354-1 [pii]
AB  - BACKGROUND: Studies into the socialisation of nursing students have tended to
      concentrate on entrant's reactions to work and on the development of knowledge
      and skills in relation to a particular occupational culture. However, the extent 
      and manner of personal and psychological changes experienced by mental health
      nursing students during occupational socialisation have yet to be thoroughly
      addressed in the literature. OBJECTIVES: To explore the psychological and
      personal changes of student mental health nurses over the first 2 years of their 
      pre-registration mental health nursing programme. DESIGN: Students from 2 mental 
      health nursing cohorts at a London university were invited to participate. A
      semi-structured interview was used and the participants were asked to talk openly
      about their experiences. Ethics approval and informed consent was sought and
      obtained. PARTICIPANTS: 20 students were selected at random and invited to be
      interviewed on 5 occasions over a 2 year period at roughly 6 month intervals.
      METHODS: A total of 72 interviews were conducted. Interviews were tape recorded
      and verbatim transcribed for quantitative and qualitative content analyses.
      RESULTS: Participants described moving from feeling uncertain, to increasing
      awareness and understanding of self and others, and, ultimately, feeling more
      accomplished in relation to their occupational world. CONCLUSIONS: This study has
      highlighted the need for supporting students in developing their confidence and
      perceptions of self-efficacy and of recognising individual differences in
      student's responses to uncertainty.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Trenoweth, Steve
AU  - Trenoweth S
AD  - College of Nursing, Midwifery and Healthcare, University of West London, Paragon 
      House, Boston Manor Road, Brentford, MIDDX TW8 9GA, United Kingdom.
      Steven.Trenoweth@uwl.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20121109
PL  - Scotland
TA  - Nurse Educ Today
JT  - Nurse education today
JID - 8511379
MH  - Humans
MH  - Longitudinal Studies
MH  - *Mental Health Services
MH  - Psychiatric Nursing/*education
MH  - Students, Nursing/*psychology
MH  - Workforce
OTO - NOTNLM
OT  - Adjustment
OT  - Education
OT  - Mental health
OT  - Nursing
OT  - Nursing students
OT  - Personal change
OT  - Psychological
EDAT- 2012/11/13 06:00
MHDA- 2015/11/06 06:00
CRDT- 2012/11/13 06:00
PHST- 2012/03/13 00:00 [received]
PHST- 2012/09/30 00:00 [revised]
PHST- 2012/10/05 00:00 [accepted]
PHST- 2012/11/13 06:00 [entrez]
PHST- 2012/11/13 06:00 [pubmed]
PHST- 2015/11/06 06:00 [medline]
AID - S0260-6917(12)00354-1 [pii]
AID - 10.1016/j.nedt.2012.10.006 [doi]
PST - ppublish
SO  - Nurse Educ Today. 2013 Aug;33(8):860-5. doi: 10.1016/j.nedt.2012.10.006. Epub
      2012 Nov 9.


PMID- 23142131
OWN - NLM
STAT- MEDLINE
DCOM- 20130510
LR  - 20121203
IS  - 1873-2518 (Electronic)
IS  - 0264-410X (Linking)
VI  - 31
IP  - 1
DP  - 2012 Dec 17
TI  - Human papillomavirus vaccination in Auckland: reducing ethnic and socioeconomic
      inequities.
PG  - 84-8
LID - 10.1016/j.vaccine.2012.10.099 [doi]
LID - S0264-410X(12)01572-1 [pii]
AB  - BACKGROUND: The New Zealand HPV publicly funded immunisation programme commenced 
      in September 2008. Delivery through a school based programme was anticipated to
      result in higher coverage rates and reduced inequalities compared to vaccination 
      delivered through other settings. The programme provided for on-going vaccination
      of girls in year 8 with an initial catch-up programme through general practices
      for young women born after 1 January 1990 until the end of 2010. OBJECTIVE: To
      assess the uptake of the funded HPV vaccine through school based vaccination
      programmes in secondary schools and general practices in 2009, and the factors
      associated with coverage by database matching. METHODS: Retrospective
      quantitative analysis of secondary anonymised data School-Based Vaccination
      Service and National Immunisation Register databases of female students from
      secondary schools in Auckland District Health Board catchment area. Data included
      student and school demographic and other variables. Binary logistic regression
      was used to estimate odds ratios and significance for univariables. Multivariable
      logistic regression estimated strength of association between individual factors 
      and initiation and completion, adjusted for all other factors. RESULTS: The
      programme achieved overall coverage of 71.5%, with Pacific girls highest at 88%
      and Maori at 78%. Girls higher socioeconomic status were more likely be
      vaccinated in general practice. CONCLUSION: School-based vaccination service
      targeted at ethic sub-populations provided equity for the Maori and Pacific
      student who achieved high levels of vaccination.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Poole, Tracey
AU  - Poole T
AD  - Immunisation Advisory Centre, Department of General Practice & Primary Health
      Care, University of Auckland, Auckland, New Zealand.
FAU - Goodyear-Smith, Felicity
AU  - Goodyear-Smith F
FAU - Petousis-Harris, Helen
AU  - Petousis-Harris H
FAU - Desmond, Natalie
AU  - Desmond N
FAU - Exeter, Daniel
AU  - Exeter D
FAU - Pointon, Leah
AU  - Pointon L
FAU - Jayasinha, Ranmalie
AU  - Jayasinha R
LA  - eng
PT  - Journal Article
DEP - 20121108
PL  - Netherlands
TA  - Vaccine
JT  - Vaccine
JID - 8406899
RN  - 0 (Papillomavirus Vaccines)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Female
MH  - Humans
MH  - Immunization Programs
MH  - Papillomavirus Infections/immunology/prevention & control
MH  - Papillomavirus Vaccines/*administration & dosage/economics
MH  - Retrospective Studies
MH  - Vaccination/statistics & numerical data
EDAT- 2012/11/13 06:00
MHDA- 2013/05/11 06:00
CRDT- 2012/11/13 06:00
PHST- 2012/04/26 00:00 [received]
PHST- 2012/10/24 00:00 [revised]
PHST- 2012/10/29 00:00 [accepted]
PHST- 2012/11/13 06:00 [entrez]
PHST- 2012/11/13 06:00 [pubmed]
PHST- 2013/05/11 06:00 [medline]
AID - S0264-410X(12)01572-1 [pii]
AID - 10.1016/j.vaccine.2012.10.099 [doi]
PST - ppublish
SO  - Vaccine. 2012 Dec 17;31(1):84-8. doi: 10.1016/j.vaccine.2012.10.099. Epub 2012
      Nov 8.


PMID- 23141760
OWN - NLM
STAT- MEDLINE
DCOM- 20131210
LR  - 20121126
IS  - 1872-6054 (Electronic)
IS  - 0168-8510 (Linking)
VI  - 108
IP  - 2-3
DP  - 2012 Dec
TI  - Regional HTA in Italy: promising or confusing?
PG  - 203-6
LID - 10.1016/j.healthpol.2012.10.010 [doi]
LID - S0168-8510(12)00291-6 [pii]
AB  - We assessed the actual implementation and achievements of regional HTA in Italy. 
      We conducted a web-based analysis (updated until July 2012). Six key elements
      were identified: availability of official documents, existence of a specific
      workgroup, involvement of external organizations, formal funds for HTA,
      publication of HTA reports, and membership of HTA networks. Then, we searched all
      HTA reports retrieved by key words to analyze whether their contents included
      clinical efficacy, economic evaluation, legal issues, ethics and organization.
      Two researchers analyzed the information separately, as a double check. Sixteen
      regions have formally established a structured workgroup inside their
      organizations. Specific funding for HTA activities could be traced in six
      regions, web-available reports only in four. Around 91% of the total reports
      concerned drugs. Contents mostly focused on epidemiological and clinical issues, 
      economic evaluation was often restricted to a brief analysis of costs. Only a few
      reports mentioned organizational implications; ethical, legal and social issues
      were lacking. This survey showed a very uneven picture of HTA in the Italian
      regions. As expected, not all the regions were able to perform HTA, probably on
      account of their wide differences in size, tradition and skills in the health
      care field.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Garattini, Livio
AU  - Garattini L
AD  - CESAV, Center for Health Economics, 'Mario Negri' Institute for Pharmacological
      Research, Via Camozzi 3, 24020 Ranica, Italy. lgarattini@marionegri.it
FAU - van de Vooren, Katelijne
AU  - van de Vooren K
FAU - Curto, Alessandro
AU  - Curto A
LA  - eng
PT  - Journal Article
DEP - 20121109
PL  - Ireland
TA  - Health Policy
JT  - Health policy (Amsterdam, Netherlands)
JID - 8409431
MH  - Cost-Benefit Analysis
MH  - Financing, Government
MH  - Humans
MH  - Italy
MH  - Regional Medical Programs/economics/*organization & administration
MH  - Technology Assessment, Biomedical/economics/methods/*organization &
      administration
EDAT- 2012/11/13 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/11/13 06:00
PHST- 2012/10/10 00:00 [received]
PHST- 2012/10/17 00:00 [revised]
PHST- 2012/10/18 00:00 [accepted]
PHST- 2012/11/13 06:00 [entrez]
PHST- 2012/11/13 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - S0168-8510(12)00291-6 [pii]
AID - 10.1016/j.healthpol.2012.10.010 [doi]
PST - ppublish
SO  - Health Policy. 2012 Dec;108(2-3):203-6. doi: 10.1016/j.healthpol.2012.10.010.
      Epub 2012 Nov 9.


PMID- 23141596
OWN - NLM
STAT- MEDLINE
DCOM- 20131118
LR  - 20121112
IS  - 1769-6682 (Electronic)
IS  - 1297-9589 (Linking)
VI  - 40 Suppl 1
DP  - 2012 Aug
TI  - [Legislative and regulatory situation of oocytes donation in France].
PG  - 28-31
LID - 10.1016/S1297-9589(12)70022-X [doi]
LID - S1297-9589(12)70022-X [pii]
AB  - In France, medically assisted procreation (MAP) activities and gamete donation
      are strictly regulated by the bioethics law. The main ethical principles applied 
      to the donation--no remuneration, anonymity, and the requirement for free and
      informed consent--aim to protect donors. In the same spirit, since MAP with
      oocytes donation is recognized as a healthcare activity, receiving couples
      benefit from exemption from co-payments by the health insurance system. Thus, it 
      is widely accessible to couples presenting medical infertility requiring oocytes 
      from a donor, but availability is insufficient to cover needs. This shortage in
      supply results in moving the demand abroad where this particular MAP is exercised
      at varying levels of supervision.
CI  - Copyright (c) 2012 Elsevier Masson SAS. All rights reserved.
FAU - Letur, H
AU  - Letur H
AD  - Centre de Fertilite, Institut Mutualiste Montsouris, Paris, France.
FAU - Merlet, F
AU  - Merlet F
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Situation legislative et reglementaire du don d'ovocytes en France.
PL  - France
TA  - Gynecol Obstet Fertil
JT  - Gynecologie, obstetrique & fertilite
JID - 100936305
SB  - IM
MH  - Bioethical Issues/*legislation & jurisprudence
MH  - Confidentiality
MH  - Female
MH  - France
MH  - Humans
MH  - Infertility, Female/therapy
MH  - Informed Consent
MH  - Oocyte Donation/*ethics/*legislation & jurisprudence
MH  - Reproductive Techniques, Assisted/ethics/legislation & jurisprudence
MH  - Tissue Donors/ethics/legislation & jurisprudence
EDAT- 2012/11/13 06:00
MHDA- 2013/11/19 06:00
CRDT- 2012/11/13 06:00
PHST- 2012/11/13 06:00 [entrez]
PHST- 2012/11/13 06:00 [pubmed]
PHST- 2013/11/19 06:00 [medline]
AID - S1297-9589(12)70022-X [pii]
AID - 10.1016/S1297-9589(12)70022-X [doi]
PST - ppublish
SO  - Gynecol Obstet Fertil. 2012 Aug;40 Suppl 1:28-31. doi:
      10.1016/S1297-9589(12)70022-X.


PMID- 23141595
OWN - NLM
STAT- MEDLINE
DCOM- 20131118
LR  - 20121112
IS  - 1769-6682 (Electronic)
IS  - 1297-9589 (Linking)
VI  - 40 Suppl 1
DP  - 2012 Aug
TI  - [Vitrification of oocytes and embryos: the law, the results, the future].
PG  - 24-7
LID - 10.1016/S1297-9589(12)70021-8 [doi]
LID - S1297-9589(12)70021-8 [pii]
AB  - The French bio ethical law published in 2004 did not authorize the transfer of
      embryos submitted to a research program, or even issued from gametes concerned by
      an experimentation. Vitrification process was still considered as an
      "experimental" technique; thus it was impossible to vitrify either oocytes or
      embryos, whereas numerous international studies emphasized the interest of this
      technique for both oocytes and embryos, in particular if they were vitrified at
      the blastocyst stage. The new revised law (7/7/2011), clearly authorizes oocyte
      vitrification; moreover, studies intended to improve ART efficiency, are now
      permitted, enabling vitrification of embryos.
CI  - Copyright (c) 2012 Elsevier Masson SAS. All rights reserved.
FAU - Guerin, J-F
AU  - Guerin JF
AD  - Service de Medecine de la Reproduction, Hopital Femme Mere Enfant, 59 bd Pinel,
      69580 Bron, France. jean-francois.guerin@univ-lyon1.fr
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Vitrification des embryons et des ovocytes: la loi, les resultats, les
      perspectives.
PL  - France
TA  - Gynecol Obstet Fertil
JT  - Gynecologie, obstetrique & fertilite
JID - 100936305
SB  - IM
MH  - Bioethical Issues/*legislation & jurisprudence
MH  - Blastocyst
MH  - Cryopreservation/*ethics/trends
MH  - Embryo Research/ethics/legislation & jurisprudence
MH  - Embryo Transfer/ethics
MH  - *Embryo, Mammalian
MH  - Female
MH  - France
MH  - Humans
MH  - Male
MH  - *Oocytes
MH  - Reproductive Techniques, Assisted/ethics/legislation & jurisprudence
EDAT- 2012/11/13 06:00
MHDA- 2013/11/19 06:00
CRDT- 2012/11/13 06:00
PHST- 2012/11/13 06:00 [entrez]
PHST- 2012/11/13 06:00 [pubmed]
PHST- 2013/11/19 06:00 [medline]
AID - S1297-9589(12)70021-8 [pii]
AID - 10.1016/S1297-9589(12)70021-8 [doi]
PST - ppublish
SO  - Gynecol Obstet Fertil. 2012 Aug;40 Suppl 1:24-7. doi:
      10.1016/S1297-9589(12)70021-8.


PMID- 23141594
OWN - NLM
STAT- MEDLINE
DCOM- 20131118
LR  - 20121112
IS  - 1769-6682 (Electronic)
IS  - 1297-9589 (Linking)
VI  - 40 Suppl 1
DP  - 2012 Aug
TI  - [Posthumous assisted reproductive technologies].
PG  - 20-3
LID - 10.1016/S1297-9589(12)70020-6 [doi]
LID - S1297-9589(12)70020-6 [pii]
AB  - Several types of posthumous ART, all exceptional, can be considered. Using frozen
      sperm by the wife or concubine results in a conception at a time when the father 
      has been dead for longer or shorter. His ban is broadly consensual in France.
      Transferring frozen embryos after the man's death raises more questions. The only
      options in France for the surviving wife are donation to another couple, donation
      to research or destruction. The National Consultative Ethics Committee was
      several times favourable to allowing this practice under certain conditions, but 
      it is still prohibited after the 2011 revision of the bioethics laws.
CI  - Copyright (c) 2012 Elsevier Masson SAS. All rights reserved.
FAU - Antoine, J-M
AU  - Antoine JM
AD  - Service de Gynecologie-Obstetrique et Medecine de la Reproduction, Universite
      Paris VI et Hopital Tenon, 4 rue de la Chine 75020 Paris, France.
      jemantoine@aol.com
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Assistance Medicale a la Procreation post-mortem.
PL  - France
TA  - Gynecol Obstet Fertil
JT  - Gynecologie, obstetrique & fertilite
JID - 100936305
SB  - IM
MH  - Bioethical Issues/*legislation & jurisprudence
MH  - Cryopreservation
MH  - Embryo Disposition/ethics/legislation & jurisprudence
MH  - Embryo Transfer/ethics
MH  - Female
MH  - France
MH  - Humans
MH  - Insemination, Artificial
MH  - Male
MH  - Oocyte Donation
MH  - Posthumous Conception/*ethics/*legislation & jurisprudence
MH  - Pregnancy
MH  - Reproductive Techniques, Assisted/*ethics/*legislation & jurisprudence
MH  - Semen Preservation
MH  - Sperm Injections, Intracytoplasmic
EDAT- 2012/11/13 06:00
MHDA- 2013/11/19 06:00
CRDT- 2012/11/13 06:00
PHST- 2012/11/13 06:00 [entrez]
PHST- 2012/11/13 06:00 [pubmed]
PHST- 2013/11/19 06:00 [medline]
AID - S1297-9589(12)70020-6 [pii]
AID - 10.1016/S1297-9589(12)70020-6 [doi]
PST - ppublish
SO  - Gynecol Obstet Fertil. 2012 Aug;40 Suppl 1:20-3. doi:
      10.1016/S1297-9589(12)70020-6.


PMID- 23141593
OWN - NLM
STAT- MEDLINE
DCOM- 20131118
LR  - 20121112
IS  - 1769-6682 (Electronic)
IS  - 1297-9589 (Linking)
VI  - 40 Suppl 1
DP  - 2012 Aug
TI  - [Embryo and stem cells researches: before and after the bioethics law of 2011].
PG  - 16-9
LID - 10.1016/S1297-9589(12)70019-X [doi]
LID - S1297-9589(12)70019-X [pii]
AB  - The bioethics law of 2004 prohibited any research on the human embryo but
      authorized by way of derogation this one. The French biomedicine agency was
      charged to take care of the scientific, legal respect and ethics of this
      research, via its council of orientation. In 5 years it took more than 100
      decisions on this subject. Although the discussions for the revision were
      important these last years, the new law of bioethics of July 7th, 2011 does not
      change anything with regard to research on the embryo and the stem cells.
CI  - Copyright (c) 2012 Elsevier Masson SAS. All rights reserved.
FAU - Merviel, P
AU  - Merviel P
AD  - Service de Gynecologie-Obstetrique et centre d'AMP, CHU Amiens, 124 rue Camille
      Desmoulins, 80054 Amiens cedex 1, France. Merviel.Philippe@chu-amiens.fr
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Les recherches sur l'embryon et les cellules souches embryonnaires: avant et
      apres la loi de bioethique de 2011.
PL  - France
TA  - Gynecol Obstet Fertil
JT  - Gynecologie, obstetrique & fertilite
JID - 100936305
SB  - IM
MH  - Bioethical Issues/*legislation & jurisprudence
MH  - Embryo Research/*ethics/*legislation & jurisprudence
MH  - France
MH  - Humans
MH  - Stem Cell Research/*ethics/*legislation & jurisprudence
EDAT- 2012/11/13 06:00
MHDA- 2013/11/19 06:00
CRDT- 2012/11/13 06:00
PHST- 2012/11/13 06:00 [entrez]
PHST- 2012/11/13 06:00 [pubmed]
PHST- 2013/11/19 06:00 [medline]
AID - S1297-9589(12)70019-X [pii]
AID - 10.1016/S1297-9589(12)70019-X [doi]
PST - ppublish
SO  - Gynecol Obstet Fertil. 2012 Aug;40 Suppl 1:16-9. doi:
      10.1016/S1297-9589(12)70019-X.


PMID- 23140850
OWN - NLM
STAT- MEDLINE
DCOM- 20140519
LR  - 20130619
IS  - 1887-1364 (Electronic)
IS  - 1134-282X (Linking)
VI  - 28
IP  - 3
DP  - 2013 May-Jun
TI  - [Evaluation of the written informed consent form in clinical trials].
PG  - 139-44
LID - 10.1016/j.cali.2012.08.003 [doi]
LID - S1134-282X(12)00119-4 [pii]
AB  - PURPOSE: To assess the quality of the written informed consent form (WICF) in
      clinical trials. MATERIAL AND METHODS: Retrospective observational study was
      performed on 50 WICF of clinical trials started between 2010 and 2011. The
      quality of the content of the WICF was assessed using the "Guideline for Good
      Clinical Practice" contained in the CPMP/ICH/135/95 of the European Medicines
      Agency. Legibility indexes were applied to the WICF. RESULTS: The WICF was
      correct in all aspects in 10% of the clinical trial; five sections were correct
      in all WICF: "trial involves research", "trials goals", "participation is
      voluntary and the subject may withdraw at any time without penalty", "study
      personnel with access to medical records" and "documents that identify the
      patient are confidential". Aspects less present were "the subject's
      responsibilities" and "available alternatives". All WICF required clarification
      by the Ethics Committee (EC), with a mean of 4.24 (SD=1.87) changes per WICF. The
      WICF showed good results in the indices of readability. Almost all (98%) of WICF 
      were considered with an acceptable readability. CONCLUSIONS: Compliance with
      different aspects that must appear in the WICF is high. Aspects to improve are
      the subject's responsibilities and available alternatives to the clinical trial. 
      The complexity of reading the WICF is suitable for the average population. The
      review of the WICF by the EC guarantees the access to comprehensive and
      appropriate information.
CI  - Copyright (c) 2012 SECA. Published by Elsevier Espana. All rights reserved.
FAU - Marrero-Alvarez, P
AU  - Marrero-Alvarez P
AD  - Servicio de Farmacia, Hospital Universitari i Politecnic La Fe, Valencia, Espana.
      marrero_pat@gva.es
FAU - Ruiz-Ramos, J
AU  - Ruiz-Ramos J
FAU - Megias-Vericat, J E
AU  - Megias-Vericat JE
FAU - Tordera-Baviera, M
AU  - Tordera-Baviera M
FAU - Poveda-Andres, J L
AU  - Poveda-Andres JL
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Observational Study
TT  - Evaluacion de la hoja de informacion al paciente y del consentimiento informado
      en ensayos clinicos.
DEP - 20121108
PL  - Spain
TA  - Rev Calid Asist
JT  - Revista de calidad asistencial : organo de la Sociedad Espanola de Calidad
      Asistencial
JID - 9601664
SB  - IM
MH  - *Clinical Trials as Topic
MH  - Comprehension
MH  - Consent Forms/*standards
MH  - Humans
MH  - Retrospective Studies
MH  - Writing
EDAT- 2012/11/13 06:00
MHDA- 2014/05/20 06:00
CRDT- 2012/11/13 06:00
PHST- 2012/04/25 00:00 [received]
PHST- 2012/08/02 00:00 [revised]
PHST- 2012/08/06 00:00 [accepted]
PHST- 2012/11/13 06:00 [entrez]
PHST- 2012/11/13 06:00 [pubmed]
PHST- 2014/05/20 06:00 [medline]
AID - S1134-282X(12)00119-4 [pii]
AID - 10.1016/j.cali.2012.08.003 [doi]
PST - ppublish
SO  - Rev Calid Asist. 2013 May-Jun;28(3):139-44. doi: 10.1016/j.cali.2012.08.003. Epub
      2012 Nov 8.


PMID- 23140800
OWN - NLM
STAT- MEDLINE
DCOM- 20140403
LR  - 20190429
IS  - 1873-5223 (Electronic)
IS  - 1471-5953 (Linking)
VI  - 13
IP  - 5
DP  - 2013 Sep
TI  - A survey of student nurses' and midwives' experiences of learning to use
      electronic health record systems in practice.
PG  - 437-41
LID - 10.1016/j.nepr.2012.10.003 [doi]
LID - S1471-5953(12)00191-6 [pii]
AB  - AIM: The study aimed to investigate student nurses' and midwives' experiences of 
      learning to use electronic health records (EHR) in practice. BACKGROUND: Good
      record keeping and documentation are integral to nursing and midwifery practice. 
      As EHRs become more widespread, student nurses and midwives need opportunities to
      access and learn how to use them in practice. METHOD: A survey of nursing and
      midwifery students was conducted using questionnaires (n = 215) and three focus
      groups: one with midwifery students (n = 6); one with mental health nursing
      students (n = 5) and one with adult nursing students (n = 6). The University
      research ethics committee approved the study. The questionnaire data were
      analysed using SPSS v19. The focus group data were analysed thematically
      following transcription. RESULTS: The results presented relate to two themes: 1) 
      Preparation for using EHRs and skills development; 2) Access to EHRs and
      involvement. Students had variable experiences in relation to opportunities to
      access and use EHRs, training on EHR systems used in practice and guidance from
      mentors. Some mentors had concerns about students' legitimacy to access EHRs and 
      verification of students' EHR entries was a challenging issue in some areas.
      CONCLUSION: To promote opportunities for students to develop competence in using 
      EHRs in practice, training on EHR systems in use, and clear processes for
      authorised access, are needed. Following the survey, the University and practice 
      partners collaboratively established formalised EHR training for students with
      clear governance procedures for access and use.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Baillie, Lesley
AU  - Baillie L
AD  - Faculty of Health and Social Care, London South Bank University, 103 Borough
      Road, London SE1 0AA, UK. baillil2@lsbu.ac.uk
FAU - Chadwick, Sandra
AU  - Chadwick S
FAU - Mann, Robert
AU  - Mann R
FAU - Brooke-Read, Melanie
AU  - Brooke-Read M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121107
PL  - Scotland
TA  - Nurse Educ Pract
JT  - Nurse education in practice
JID - 101090848
SB  - IM
MH  - Adult
MH  - Cross-Sectional Studies
MH  - *Education, Nursing, Baccalaureate
MH  - *Electronic Health Records
MH  - Female
MH  - Focus Groups
MH  - Humans
MH  - Midwifery/education
MH  - Nursing Informatics/*education
MH  - Pregnancy
MH  - Program Evaluation
MH  - United Kingdom
OTO - NOTNLM
OT  - Competence
OT  - Electronic health records
OT  - Practice learning
OT  - Student nurses and midwives
EDAT- 2012/11/13 06:00
MHDA- 2014/04/04 06:00
CRDT- 2012/11/13 06:00
PHST- 2012/03/14 00:00 [received]
PHST- 2012/09/30 00:00 [revised]
PHST- 2012/10/17 00:00 [accepted]
PHST- 2012/11/13 06:00 [entrez]
PHST- 2012/11/13 06:00 [pubmed]
PHST- 2014/04/04 06:00 [medline]
AID - S1471-5953(12)00191-6 [pii]
AID - 10.1016/j.nepr.2012.10.003 [doi]
PST - ppublish
SO  - Nurse Educ Pract. 2013 Sep;13(5):437-41. doi: 10.1016/j.nepr.2012.10.003. Epub
      2012 Nov 7.


PMID- 23140480
OWN - NLM
STAT- MEDLINE
DCOM- 20130531
LR  - 20211021
IS  - 1471-244X (Electronic)
IS  - 1471-244X (Linking)
VI  - 12
DP  - 2012 Nov 9
TI  - The Relaxation Exercise and Social Support Trial (RESST): a community-based
      randomized controlled trial to alleviate medically unexplained vaginal discharge 
      symptoms.
PG  - 195
LID - 10.1186/1471-244X-12-195 [doi]
AB  - BACKGROUND: Symptoms such as medically unexplained vaginal discharge (MUVD) are
      common and bothersome, leading to potentially unnecessary use of resources.
      METHODS: A community-based individually randomized controlled trial to assess the
      effectiveness of a relatively simple, culturally appropriate multi-component
      intervention on reducing reported MUVD, among women suffering from low-moderate
      levels of common mental distress. The setting was a socio-economically deprived, 
      informal settlement in the southern suburbs of Beirut, Lebanon. The intervention 
      comprised up to 12 group sessions implemented over a six-week period, each
      divided into a psychosocial and a relaxation exercise component. The primary
      outcome was self-reported MUVD, which was defined as a complaint of vaginal
      discharge upon ruling out reproductive tract infections (RTIs), through lab
      analysis. Anxiety and/or depression symptoms were the secondary outcomes for this
      trial. These were assessed using an Arabic validated version of the Hopkins
      Symptoms Checklist-25 (HSCL-25). Assessments were done at baseline and six months
      using face-to face interviews, pelvic examinations and laboratory tests. Women
      were randomized into either intervention or control group. Blinding on the
      intervention status was not possible for both logistic and ethical reasons,
      especially as knowledge of involvement in the intervention was integral to its
      delivery. Intent to treat analysis was used. RESULTS: Of 75 women randomized to
      the intervention, 48% reported MUVD at 6 months compared with 63% of 73 in the
      control group (difference of -15%, 95% confidence interval (CI) -31%, 0%,
      p=0.067). Adjustments for baseline imbalances and any factors relating to consent
      had no appreciable effect on these results. The risk of MUVD was reduced in
      absolute terms by 2.4% for each intervention session attended (95% CI -4.9%,
      0.0%, p=0.049). While there was also marginal evidence of a beneficial effect on 
      anxiety, there was no evidence of mediation of the effect on MUVD through
      measures of common mental disorders. CONCLUSION: This study confirms that MUVD is
      an important public health problem. While the benefits of this intervention may
      appear modest, the intervention offers an opportunity for women to enhance their 
      problem-solving skills as well as use physical relaxation techniques that can
      help them deal with stressful in their lives. Further research is needed in a
      variety of contexts, for different populations and preferably involving larger
      randomized trials of such an intervention. TRIAL REGISTRATION: * Title of trial: 
      The Relaxation Exercise and Social Support Trial ISRCTN assigned: ISRCTN98441241 
      Date of assignation: 10/09/2010 Link:
      http://www.controlled-trials.com/ISRCTN98441241* Also registered at the Wellcome 
      Trust register:http://www.controlled-trials.com/mrct/trial/469943/98441241.
FAU - Kobeissi, Loulou
AU  - Kobeissi L
AD  - Epidemiology and Biostatistics Division, Center for Middle Eastern Studies,
      University of Arizona, Tucson, Arizona, USA.
FAU - Mahfoud, Ziyad
AU  - Mahfoud Z
FAU - Khoury, Brigitte
AU  - Khoury B
FAU - El Kak, Fayssal
AU  - El Kak F
FAU - Ghantous, Zeina
AU  - Ghantous Z
FAU - Khawaja, Marwan
AU  - Khawaja M
FAU - Nakkash, Rima
AU  - Nakkash R
FAU - Ramia, Sami
AU  - Ramia S
FAU - Zurayk, Huda
AU  - Zurayk H
FAU - Araya, Ricardo
AU  - Araya R
FAU - Peters, Tim J
AU  - Peters TJ
LA  - eng
SI  - ISRCTN/ISRCTN98441241
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20121109
PL  - England
TA  - BMC Psychiatry
JT  - BMC psychiatry
JID - 100968559
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Comorbidity
MH  - Exercise Therapy/*methods
MH  - Female
MH  - Humans
MH  - Lebanon
MH  - Mental Disorders/epidemiology
MH  - Middle Aged
MH  - Poverty
MH  - Psychiatric Status Rating Scales
MH  - Psychotherapy, Group/*methods
MH  - Social Support
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
MH  - Vaginal Discharge/epidemiology/*therapy
MH  - Young Adult
PMC - PMC3534445
EDAT- 2012/11/13 06:00
MHDA- 2013/06/01 06:00
CRDT- 2012/11/13 06:00
PHST- 2012/04/20 00:00 [received]
PHST- 2012/10/25 00:00 [accepted]
PHST- 2012/11/13 06:00 [entrez]
PHST- 2012/11/13 06:00 [pubmed]
PHST- 2013/06/01 06:00 [medline]
AID - 1471-244X-12-195 [pii]
AID - 10.1186/1471-244X-12-195 [doi]
PST - epublish
SO  - BMC Psychiatry. 2012 Nov 9;12:195. doi: 10.1186/1471-244X-12-195.


PMID- 23140305
OWN - NLM
STAT- MEDLINE
DCOM- 20130429
LR  - 20121112
IS  - 1466-187X (Electronic)
IS  - 0142-159X (Linking)
VI  - 34
IP  - 11
DP  - 2012
TI  - Values add value: an online tool enhances postgraduate evidence-based practice
      learning.
PG  - e743-50
LID - 10.3109/0142159X.2012.689439 [doi]
AB  - BACKGROUND: To better prepare practitioners for the complex world of clinical
      decision-making, teaching evidence-based practice needs to move beyond its focus 
      on skills and knowledge to give students an experience and understanding of
      applying evidence in practice. AIM: To explore whether incorporating an online
      values-based tool enhanced learning in a post graduate epidemiology course.
      METHODS: Having completed a critical appraisal of an epidemiological study,
      students were asked to then respond to a case scenario, using the analytical
      frameworks of the Values-Exchange, a software tool that highlights ethical
      domains in decision-making. The student experience of the Values-Exchange was
      evaluated using focus groups. Sessions were audiotaped and transcribed. In total,
      613 responses were analysed by two independent coders to identify emergent
      themes. RESULTS: Three main themes emerged: (1) the Values-Exchange exposed
      students to new concepts and ideas relating to healthcare decision-making; (2)
      the diversity of other student values broadened their perspectives and (3) the
      experience brought reality to what it means to apply evidence in practice.
      CONCLUSION: Adding an online values-based tool to clinical epidemiology teaching 
      was highly valued by students and enabled new understandings of empirical
      evidence and its application in practice.
FAU - Robb, Gillian
AU  - Robb G
AD  - Epidemiology and Biostatistics, Level 4, School of Population Health, Tamaki
      Innovation Campus, The University of Auckland, Private Bag 92019, Auckland 1142, 
      New Zealand. g.robb@auckland.ac.nz
FAU - Wells, Susan
AU  - Wells S
FAU - Goodyear-Smith, Felicity
AU  - Goodyear-Smith F
LA  - eng
PT  - Journal Article
PL  - England
TA  - Med Teach
JT  - Medical teacher
JID - 7909593
SB  - IM
MH  - Adult
MH  - *Decision Making
MH  - Epidemiology/*education
MH  - Ethics, Clinical
MH  - Evidence-Based Medicine/*education
MH  - Female
MH  - Humans
MH  - *Internet
MH  - Male
MH  - Middle Aged
EDAT- 2012/11/13 06:00
MHDA- 2013/04/30 06:00
CRDT- 2012/11/13 06:00
PHST- 2012/11/13 06:00 [entrez]
PHST- 2012/11/13 06:00 [pubmed]
PHST- 2013/04/30 06:00 [medline]
AID - 10.3109/0142159X.2012.689439 [doi]
PST - ppublish
SO  - Med Teach. 2012;34(11):e743-50. doi: 10.3109/0142159X.2012.689439.


PMID- 23140064
OWN - NLM
STAT- MEDLINE
DCOM- 20121129
LR  - 20191112
IS  - 1932-149X (Print)
IS  - 1932-149X (Linking)
VI  - 7
IP  - 3
DP  - 2012 Summer
TI  - Ethical implications of diversity in disaster research.
PG  - 211-21
AB  - Enhancing the effectiveness, efficiency, and fairness of interventions is an
      increasing source of concern in the field of disaster response. As a result, the 
      expansion of the disaster relief evidence base has been identified as a pressing 
      need. There has been a corresponding increase in discussions of ethical standards
      and procedures for disaster research. In general, these discussions have focused 
      on elucidating how traditional research ethics concerns can be operationalized in
      disaster settings. Less attention has been given to the exploration of the
      ethical implications of heterogeneity within the field of disaster research.
      Hence, while current efforts to discuss the ethics of disaster research in
      low-resource settings are very encouraging, it is clear that further initiatives 
      will be crucial to promote the ethical conduct of disaster research. In this
      article, we explore how the ethical review of disaster research conducted in
      low-resource settings should account for this diversity. More specifically, we
      consider how the nature of the project (what?), sociopolitical and physical
      environment of research sites (where?), temporal proximity to the disaster event 
      (when?), objectives motivating the research (why?), and identity of the
      stakeholders involved in the research process (who?) all relate to the ethics of 
      disaster research.
FAU - Hunt, Matthew R
AU  - Hunt MR
AD  - School of Physical and Occupational Therapy, McGill University, Montreal, Quebec,
      Canada.
FAU - Anderson, James A
AU  - Anderson JA
FAU - Boulanger, Renaud F
AU  - Boulanger RF
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Disaster Med
JT  - American journal of disaster medicine
JID - 101291100
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Attitude to Health/ethnology
MH  - Biomedical Research/*ethics
MH  - *Cultural Diversity
MH  - Disaster Planning/*methods
MH  - Emergency Medicine/*ethics
MH  - Female
MH  - Health Planning/*ethics
MH  - Health Priorities/*ethics
MH  - Humans
MH  - Male
MH  - Principle-Based Ethics
EDAT- 2012/11/13 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/11/13 06:00
PHST- 2012/11/13 06:00 [entrez]
PHST- 2012/11/13 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.5055/ajdm.2012.0096 [doi]
PST - ppublish
SO  - Am J Disaster Med. 2012 Summer;7(3):211-21. doi: 10.5055/ajdm.2012.0096.


PMID- 23139981
OWN - NLM
STAT- MEDLINE
DCOM- 20121217
LR  - 20121112
IS  - 0030-9982 (Print)
IS  - 0030-9982 (Linking)
VI  - 62
IP  - 9
DP  - 2012 Sep
TI  - Acute appendicitis in the elderly; Pakistan Ordnance Factories Hospital, Wah
      Cantt. experience.
PG  - 946-9
AB  - OBJECTIVE: To review the clinical experience in diagnosis, management and outcome
      of elderly patients presenting with acute appendicitis at the Pakistan Ordnance
      Factories Hospital, Wah Cantt. METHODS: All patients of age 60 years and above
      presenting with abdominal pain were prospectively reviewed. Patients who were
      diagnosed as acute appendicitis were included in this case series which was
      conducted at Pakistan Ordnance Factories Hospital, Wah Cantt, from December 2006 
      to May 2008. Detailed history and clinical examination, co-morbid conditions,
      clinical manifestations and post-operative outcome were recorded. The diagnosis
      was made on the basis of history and clinical examination. The diagnosis was also
      confirmed on histopathology. All the details were recorded on a questionnaire.
      Approval from our own ethical committee was taken. SPSS 16 was used for
      statistical analysis. RESULTS: A total of 75 patients presented with acute
      abdominal pain. Of them 42 were admitted with tenderness in right iliac fossa and
      lower abdomen. Finally, 36 (48%) were diagnosed as acute appendicitis and were
      included in the study. There were 20(56%) men and 16(44%) women with age range of
      60 to 78 years and a mean age of 65.5 +/- 4.2 years. Associated illness occurred 
      in 25(70%) patients. Symptoms included abdominal pain in 32(90%), nausea in
      17(48%), and emesis in 9(25%) patients. Signs included right lower quadrant
      tenderness in 26(74%) patients, leukocytosis in 17(47.2%), and fever (>99'F) in
      11(30.5%). Laparoscopy was used as an important diagnostic as well as therapeutic
      modality. Of the patients, 9 (25%) had gangrenous appendix, while 12 (33.3%) had 
      perforated appendix. A total of 12 (33.4%) patients developed complications.
      Hospital stay was considerably increased in patients with a delayed diagnosis
      (5-7 days), perforations (5-9 days) and postoperative complications (5-15 days). 
      One patient, a known case of ischaemic heart disease, died of cardiopulmonary
      arrest. CONCLUSION: Acute appendicitis needs to be considered in the differential
      diagnosis of all patients with abdominal pain. A high index of suspicion is
      necessary to guard against mis-diagnosis, especially in the elderly. Delays in
      presentation and diagnosis are associated with higher rates of perforation and,
      hence, higher morbidity. Repeated clinical examination, a high index of suspicion
      and urgent investigations are necessary for a correct and rapid diagnosis.
FAU - Salahuddin, Omer
AU  - Salahuddin O
AD  - Pakistan Ordnance Factories Hospital, Wah Cantt.
FAU - Malik, Muzaffar Ali Nasir
AU  - Malik MA
FAU - Sajid, Muhammad Ali
AU  - Sajid MA
FAU - Azhar, Muhammad
AU  - Azhar M
FAU - Dilawar, Omer
AU  - Dilawar O
FAU - Salahuddin, Ayesha
AU  - Salahuddin A
LA  - eng
PT  - Journal Article
PL  - Pakistan
TA  - J Pak Med Assoc
JT  - JPMA. The Journal of the Pakistan Medical Association
JID - 7501162
SB  - IM
MH  - Abdominal Pain/*diagnosis/epidemiology/etiology
MH  - Acute Disease
MH  - Aged
MH  - *Appendectomy/adverse effects/methods/statistics & numerical data
MH  - *Appendicitis/complications/diagnosis/epidemiology/surgery
MH  - Appendix/pathology
MH  - Delayed Diagnosis/adverse effects/prevention & control/statistics & numerical
      data
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Intestinal Perforation/*diagnosis/epidemiology/etiology
MH  - Male
MH  - Medical History Taking
MH  - Middle Aged
MH  - Pakistan/epidemiology
MH  - Physical Examination
MH  - Postoperative Complications/*epidemiology
MH  - Treatment Outcome
EDAT- 2012/11/13 06:00
MHDA- 2012/12/18 06:00
CRDT- 2012/11/13 06:00
PHST- 2012/11/13 06:00 [entrez]
PHST- 2012/11/13 06:00 [pubmed]
PHST- 2012/12/18 06:00 [medline]
AID - 3679 [pii]
PST - ppublish
SO  - J Pak Med Assoc. 2012 Sep;62(9):946-9.


PMID- 23139607
OWN - NLM
STAT- MEDLINE
DCOM- 20131112
LR  - 20211021
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Linking)
VI  - 18
IP  - 41
DP  - 2012 Nov 7
TI  - Human thrombin for the treatment of gastric and ectopic varices.
PG  - 5912-7
LID - 10.3748/wjg.v18.i41.5912 [doi]
AB  - AIM: To evaluate the efficacy of human thrombin in the treatment of bleeding
      gastric and ectopic varices. METHODS: Retrospective observational study in a
      Tertiary Referral Centre. Between January 1999-October 2005, we identified 37
      patients who were endoscopically treated with human thrombin injection therapy
      for bleeding gastric and ectopic varices. Patient details including age, gender
      and aetiology of liver disease/segmental portal hypertension were documented. The
      thrombin was obtained from the Scottish National Blood Transfusion Service and
      prepared to give a solution of 250 IU/mL which was injected via a standard
      injection needle. All patient case notes were reviewed and the total dose of
      thrombin given along with the number of endoscopy sessions was recorded. Initial 
      haemostasis rates, rebleeding rates and mortality were catalogued along with the 
      incidence of any immediate complications which could be attributable to the
      thrombin therapy. The duration of follow up was also listed. The study was
      conducted according to the United Kingdom research ethics guidelines. RESULTS:
      Thirty-seven patients were included. 33 patients (89%) had thrombin (250 U/mL)
      for gastric varices, 2 (5.4%) for duodenal varices, 1 for rectal varices and 1
      for gastric and rectal varices. (1) Gastric varices, an average of 15.2 mL of
      thrombin was used per patient. Re-bleeding occurred in 4 patients (10.8%),
      managed in 2 by a transjugular intrahepatic portosystemic shunt (TIPSS) (one
      unsuccessfully who died) and in other 2 by a distal splenorenal shunt; (2)
      Duodenal varices (or type 2 isolated gastric varices), an average of 12.5 mL was 
      used per patient over 2-3 endoscopy sessions. Re-bleeding occurred in one
      patient, which was treated by TIPSS; and (3) Rectal varices, an average of 18.3
      mL was used per patient over 3 endoscopy sessions. No re-bleeding occurred in
      this group. CONCLUSION: Human thrombin is a safe, easy to use and effective
      therapeutic option to control haemorrhage from gastric and ectopic varices.
FAU - McAvoy, Norma C
AU  - McAvoy NC
AD  - Department of Hepatology, University of Edinburgh, Royal Infirmary of Edinburgh, 
      Edinburgh EH16 4SA, United Kingdom. norma.mcavoy@ed.ac.uk
FAU - Plevris, John N
AU  - Plevris JN
FAU - Hayes, Peter C
AU  - Hayes PC
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
RN  - 0 (Hemostatics)
RN  - EC 3.4.21.5 (Thrombin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Esophageal and Gastric Varices/*drug therapy/mortality
MH  - Female
MH  - Gastrointestinal Hemorrhage/*drug therapy/mortality
MH  - Hemostasis, Endoscopic/adverse effects/*methods/mortality
MH  - Hemostatics/administration & dosage/adverse effects/*therapeutic use
MH  - Humans
MH  - Injections
MH  - Male
MH  - Middle Aged
MH  - Recurrence
MH  - Retrospective Studies
MH  - Tertiary Care Centers
MH  - Thrombin/administration & dosage/adverse effects/*therapeutic use
MH  - Time Factors
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC3491598
OTO - NOTNLM
OT  - Ectopic Varices
OT  - Gastric varices
OT  - Portal hypertension
OT  - Thrombin
OT  - Variceal haemorrhage
EDAT- 2012/11/10 06:00
MHDA- 2013/11/13 06:00
CRDT- 2012/11/10 06:00
PHST- 2012/03/15 00:00 [received]
PHST- 2012/05/11 00:00 [revised]
PHST- 2012/05/26 00:00 [accepted]
PHST- 2012/11/10 06:00 [entrez]
PHST- 2012/11/10 06:00 [pubmed]
PHST- 2013/11/13 06:00 [medline]
AID - 10.3748/wjg.v18.i41.5912 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2012 Nov 7;18(41):5912-7. doi: 10.3748/wjg.v18.i41.5912.


PMID- 23138993
OWN - NLM
STAT- MEDLINE
DCOM- 20150813
LR  - 20220408
IS  - 1306-696X (Print)
VI  - 18
IP  - 4
DP  - 2012 Jul
TI  - The relationship of trauma severity and mortality with cardiac enzymes and
      cytokines at multiple trauma patients.
PG  - 289-95
LID - 10.5505/tjtes.2012.81488 [doi]
AB  - BACKGROUND: In this study, we aimed to determine the effects of trauma severity
      on cardiac involvement through evaluating the trauma severity score together with
      diagnostic tests in multiple trauma patients. A trauma score was determined using
      various trauma severity scales. METHODS: After obtaining the approval of the
      ethics committee of the faculty, this prospective study was performed through
      evaluating 100 multiple trauma patients, aged over 15 years, who applied to our
      Emergency Department (ED). After determining the trauma severity score using
      instruments such as the Injury Severity Score (ISS), Glasgow Coma Scale (GCS),
      and Revised Trauma Score (RTS), the cardiac condition was evaluated using
      biochemical and radiological diagnostic tests. RESULTS: During the study period, 
      100 patients were evaluated (78 male, 22 female; mean age: 33.2+/-15.4; range 15 
      to 70 years). It was determined that 92 (92%) were blunt trauma cases, and 77
      (77%) of them were due to traffic accidents. The majority of cases showed
      electrocardiogram (ECG) abnormalities (63%) and sinus tachycardia (36%). Abnormal
      echocardiogram (ECHO) findings, mostly accompanied by ventricular defects (n=24),
      were determined in 31 of the cases. Nineteen cases with high trauma severity
      score resulted in death, and 14 of all deaths were secondary to traffic
      accidents. Trauma scores were found to show a significant difference between the 
      two groups. CONCLUSION: The ISS trauma scale was determined to be the most
      effective in terms of indicating heart involvement in patients with multiple
      traumas. Close follow-up and cardiac monitoring should be applied to patients
      with high trauma severity scores considering possible cardiac rhythm changes and 
      hemodynamic disturbances due to cardiac involvement.
FAU - Karakus, Ali
AU  - Karakus A
AD  - Department of Emergency Medicine, Mustafa Kemal University Faculty of Medicine,
      Hatay, Turkey. drkarakus@yahoo.com
FAU - Kekec, Zeynep
AU  - Kekec Z
FAU - Akcan, Ramazan
AU  - Akcan R
FAU - Seydaoglu, Gulsah
AU  - Seydaoglu G
LA  - eng
PT  - Journal Article
PL  - Turkey
TA  - Ulus Travma Acil Cerrahi Derg
JT  - Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency
      surgery : TJTES
JID - 101274231
RN  - 0 (Cytokines)
RN  - 0 (Troponin T)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 2.7.3.2 (Creatine Kinase, MB Form)
SB  - IM
MH  - Accidents, Traffic/mortality
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Arrhythmias, Cardiac/complications
MH  - Creatine Kinase, MB Form/analysis
MH  - Cytokines/*metabolism
MH  - Echocardiography
MH  - Electrocardiography
MH  - Female
MH  - Glasgow Coma Scale
MH  - Heart Diseases/*complications/diagnosis/enzymology/immunology
MH  - Hemodynamics
MH  - Humans
MH  - Injury Severity Score
MH  - Length of Stay
MH  - Luminescent Measurements
MH  - Male
MH  - Middle Aged
MH  - Multiple Trauma/enzymology/immunology/mortality/*physiopathology
MH  - *Trauma Severity Indices
MH  - Troponin T/analysis
MH  - Tumor Necrosis Factor-alpha/analysis
MH  - Vital Signs
MH  - Wounds, Nonpenetrating/enzymology/immunology/mortality/physiopathology
MH  - Young Adult
EDAT- 2012/11/10 06:00
MHDA- 2015/08/14 06:00
CRDT- 2012/11/10 06:00
PHST- 2012/11/10 06:00 [entrez]
PHST- 2012/11/10 06:00 [pubmed]
PHST- 2015/08/14 06:00 [medline]
AID - 10.5505/tjtes.2012.81488 [doi]
PST - ppublish
SO  - Ulus Travma Acil Cerrahi Derg. 2012 Jul;18(4):289-95. doi:
      10.5505/tjtes.2012.81488.


PMID- 23138982
OWN - NLM
STAT- MEDLINE
DCOM- 20130926
LR  - 20220408
IS  - 1432-1459 (Electronic)
IS  - 0340-5354 (Linking)
VI  - 260
IP  - 4
DP  - 2013 Apr
TI  - Quantitative MRI and loss of free ambulation in Duchenne muscular dystrophy.
PG  - 969-74
LID - 10.1007/s00415-012-6733-x [doi]
AB  - The purpose of this ethics approved trial was to correlate quantitative MRI with 
      functional abilities in both ambulant and non-ambulant Duchenne muscular
      dystrophy (DMD). Twenty patients with genetically confirmed DMD were recruited.
      Physical assessment was performed using the motor function measurement (MFM)
      scale. Axial 3T MRI scans of the thighs were acquired using T1-weighted in- and
      opposed-phase images (TR = 20 ms, TE1 = 2.45 ms, TE2 = 3.68 ms, flip angle = 15
      degrees ) to calculate the relative fat fraction according to the two-point Dixon
      method in the knee extensors, flexors, and adductor muscles. The average MFM was 
      65.3 % and correlated negatively to age (r (2) = 0.60). Overall mean fat fraction
      correlated positively to age (r (2) = 0.51-0.64). An average of 5 % increase in
      mean fat fraction per year was calculated. Mean fat fraction of the quadriceps
      showed a high negative correlation (r (2) = 0.93) to the D1 (standing position
      and transfers) component of the MFM. A cutoff for mean fat fraction of 50 %
      predicted loss of ambulation with a sensitivity of 100 % and a specificity of 91 
      %. Therefore, quantitative muscle MRI seems to be a promising endpoint for short 
      clinical trials evaluating the effect of newer treatments on the time of loss of 
      ambulation in DMD.
FAU - Fischmann, Arne
AU  - Fischmann A
AD  - Division of Diagnostic and Interventional Neuroradiology, Department of
      Radiology, University of Basel Hospital, Petersgraben 4, 4031 Basel, Switzerland.
      arne.fischmann@unibas.ch
FAU - Hafner, Patricia
AU  - Hafner P
FAU - Gloor, Monika
AU  - Gloor M
FAU - Schmid, Maurice
AU  - Schmid M
FAU - Klein, Andrea
AU  - Klein A
FAU - Pohlman, Urs
AU  - Pohlman U
FAU - Waltz, Tanja
AU  - Waltz T
FAU - Gonzalez, Rocio
AU  - Gonzalez R
FAU - Haas, Tanja
AU  - Haas T
FAU - Bieri, Oliver
AU  - Bieri O
FAU - Fischer, Dirk
AU  - Fischer D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121109
PL  - Germany
TA  - J Neurol
JT  - Journal of neurology
JID - 0423161
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Disability Evaluation
MH  - Female
MH  - Functional Laterality
MH  - Gait Disorders, Neurologic/*etiology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Muscle, Skeletal/pathology
MH  - Muscular Dystrophy, Duchenne/*complications/*pathology
MH  - Walking/*physiology
MH  - Young Adult
EDAT- 2012/11/10 06:00
MHDA- 2013/09/27 06:00
CRDT- 2012/11/10 06:00
PHST- 2012/08/01 00:00 [received]
PHST- 2012/10/24 00:00 [accepted]
PHST- 2012/10/11 00:00 [revised]
PHST- 2012/11/10 06:00 [entrez]
PHST- 2012/11/10 06:00 [pubmed]
PHST- 2013/09/27 06:00 [medline]
AID - 10.1007/s00415-012-6733-x [doi]
PST - ppublish
SO  - J Neurol. 2013 Apr;260(4):969-74. doi: 10.1007/s00415-012-6733-x. Epub 2012 Nov
      9.


PMID- 23138785
OWN - NLM
STAT- MEDLINE
DCOM- 20131113
LR  - 20181202
IS  - 1476-5373 (Electronic)
IS  - 0007-0610 (Linking)
VI  - 213
IP  - 9
DP  - 2012 Nov
TI  - Ethics of health screening.
PG  - 434
LID - 10.1038/sj.bdj.2012.996 [doi]
FAU - Sjogren, P
AU  - Sjogren P
LA  - eng
PT  - Letter
PT  - Comment
PL  - England
TA  - Br Dent J
JT  - British dental journal
JID - 7513219
SB  - IM
CON - Br Dent J. 2012 Aug;213(4):146. PMID: 22918325
MH  - *Dentists
MH  - *Health Status
MH  - Humans
MH  - *Mass Screening
MH  - *Primary Prevention
EDAT- 2012/11/10 06:00
MHDA- 2013/11/14 06:00
CRDT- 2012/11/10 06:00
PHST- 2012/11/10 06:00 [entrez]
PHST- 2012/11/10 06:00 [pubmed]
PHST- 2013/11/14 06:00 [medline]
AID - sj.bdj.2012.996 [pii]
AID - 10.1038/sj.bdj.2012.996 [doi]
PST - ppublish
SO  - Br Dent J. 2012 Nov;213(9):434. doi: 10.1038/sj.bdj.2012.996.


PMID- 23138517
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20180814
IS  - 1868-8551 (Electronic)
IS  - 1868-596X (Linking)
VI  - 29
IP  - 4
DP  - 2012
TI  - Outcomes of a Dutch workshop on improvements for the 3Rs in daily practice.
PG  - 440-3
LID - 10.14573/altex.2012.4.440 [doi]
AB  - This article describes the outcome of a workshop that was held to generate new
      ideas to improve the use of the 3R principles in science. The participants of the
      workshop represented Dutch researchers, Animal Welfare Officers, and members of
      Animal Ethics Committees from various affiliations, including academia, industry,
      contract research organizations, and knowledge centers in the Netherlands. The
      workshop resulted in six diverse consensus statements, which are presented and
      discussed in this article. The results show that there is no single,
      straightforward solution to improving the implementation of 3R methods in
      animal-based research and that further improvement in 3Rs practice requires a
      more multi- and interdisciplinary awareness and approach.
FAU - van Luijk, Judith
AU  - van Luijk J
AD  - SYRCLE, Central Animal Laboratory, Radboud University Nijmegen Medical Centre,
      The Netherlands.
FAU - Leenaars, Marlies
AU  - Leenaars M
AD  - SYRCLE, Central Animal Laboratory, Radboud University Nijmegen Medical Centre,
      The Netherlands.
FAU - van Dongen, Anne Marie
AU  - van Dongen AM
AD  - Vaart Innovation and Knowledge Management, Oisterwijk, The Netherlands.
FAU - van der Vaart, Lilian
AU  - van der Vaart L
AD  - Vaart Innovation and Knowledge Management, Oisterwijk, The Netherlands.
FAU - Ritskes-Hoitinga, Merel
AU  - Ritskes-Hoitinga M
AD  - SYRCLE, Central Animal Laboratory, Radboud University Nijmegen Medical Centre,
      The Netherlands.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - ALTEX
JT  - ALTEX
JID - 100953980
SB  - IM
MH  - Animal Testing Alternatives/*methods
MH  - Animal Welfare
MH  - Animals
MH  - Animals, Laboratory
MH  - Ethics, Research
MH  - Interdisciplinary Communication
MH  - Netherlands
MH  - *Research Design
EDAT- 2012/11/10 06:00
MHDA- 2013/03/13 06:00
CRDT- 2012/11/10 06:00
PHST- 2012/11/10 06:00 [entrez]
PHST- 2012/11/10 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
AID - 10.14573/altex.2012.4.440 [doi]
PST - ppublish
SO  - ALTEX. 2012;29(4):440-3. doi: 10.14573/altex.2012.4.440.


PMID- 23138499
OWN - NLM
STAT- MEDLINE
DCOM- 20131127
LR  - 20211021
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 24
IP  - 4
DP  - 2012 Dec
TI  - How virtue ethics informs medical professionalism.
PG  - 257-72
LID - 10.1007/s10730-012-9202-0 [doi]
AB  - We argue that a turn toward virtue ethics as a way of understanding medical
      professionalism represents both a valuable corrective and a missed opportunity.
      We look at three ways in which a closer appeal to virtue ethics could help
      address current problems or issues in professionalism education-first, balancing 
      professionalism training with demands for professional virtues as a prerequisite;
      second, preventing demands for the demonstrable achievement of competencies from 
      working against ideal professionalism education as lifelong learning; and third, 
      avoiding temptations to dismiss moral distress as a mere "hidden curriculum"
      problem. As a further demonstration of how best to approach a lifelong practice
      of medical virtue, we will examine altruism as a mean between the extremes of
      self-sacrifice and selfishness.
FAU - McCammon, Susan D
AU  - McCammon SD
AD  - Department of Otolaryngology-Head and Neck Surgery, University of Texas Medical
      Branch, 301 University Boulevard, Galveston, TX 77555-0521, USA.
      sdmccamm@utmb.edu
FAU - Brody, Howard
AU  - Brody H
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - Altruism
MH  - Education, Medical/*ethics
MH  - *Ethical Theory
MH  - Ethics, Medical
MH  - Humans
MH  - *Professional Competence
MH  - *Virtues
EDAT- 2012/11/10 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/11/10 06:00
PHST- 2012/11/10 06:00 [entrez]
PHST- 2012/11/10 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1007/s10730-012-9202-0 [doi]
PST - ppublish
SO  - HEC Forum. 2012 Dec;24(4):257-72. doi: 10.1007/s10730-012-9202-0.


PMID- 23138369
OWN - NLM
STAT- MEDLINE
DCOM- 20121207
LR  - 20140325
IS  - 0093-0334 (Print)
IS  - 0093-0334 (Linking)
VI  - 42
IP  - 6
DP  - 2012 Nov-Dec
TI  - The ethics of evidence.
PG  - 29-30
LID - 10.1002/hast.92 [doi]
FAU - Biller-Andorno, Nikola
AU  - Biller-Andorno N
FAU - Wild, Verina
AU  - Wild V
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Hastings Cent Rep
JT  - The Hastings Center report
JID - 0410447
SB  - IM
MH  - Adolescent
MH  - Africa
MH  - Child
MH  - Circumcision, Female/*ethics
MH  - *Cultural Characteristics
MH  - Ethical Analysis
MH  - Evidence-Based Medicine/ethics
MH  - Female
MH  - Freedom
MH  - Humans
MH  - Informed Consent/*standards
MH  - *Social Stigma
MH  - Young Adult
EDAT- 2012/11/10 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/11/10 06:00
PHST- 2012/11/10 06:00 [entrez]
PHST- 2012/11/10 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - 10.1002/hast.92 [doi]
PST - ppublish
SO  - Hastings Cent Rep. 2012 Nov-Dec;42(6):29-30. doi: 10.1002/hast.92.


PMID- 23138232
OWN - NLM
STAT- MEDLINE
DCOM- 20140122
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 3
DP  - 2013 Sep
TI  - Ethics, finance, and automation: a preliminary survey of problems in high
      frequency trading.
PG  - 851-74
LID - 10.1007/s11948-012-9412-5 [doi]
AB  - All of finance is now automated, most notably high frequency trading. This paper 
      examines the ethical implications of this fact. As automation is an
      interdisciplinary endeavor, we argue that the interfaces between the respective
      disciplines can lead to conflicting ethical perspectives; we also argue that
      existing disciplinary standards do not pay enough attention to the ethical
      problems automation generates. Conflicting perspectives undermine the protection 
      those who rely on trading should have. Ethics in finance can be expanded to
      include organizational and industry-wide responsibilities to external market
      participants and society. As a starting point, quality management techniques can 
      provide a foundation for a new cross-disciplinary ethical standard in the age of 
      automation.
FAU - Davis, Michael
AU  - Davis M
AD  - Illinois Institute of Technology, Chicago, IL 60616, USA. davism@iit.edu
FAU - Kumiega, Andrew
AU  - Kumiega A
FAU - Van Vliet, Ben
AU  - Van Vliet B
LA  - eng
PT  - Journal Article
DEP - 20121109
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Automation/*ethics
MH  - Commerce/*ethics
MH  - Data Collection
MH  - *Ethics, Business
MH  - Humans
MH  - Quality Control
EDAT- 2012/11/10 06:00
MHDA- 2014/01/23 06:00
CRDT- 2012/11/10 06:00
PHST- 2012/06/15 00:00 [received]
PHST- 2012/10/12 00:00 [accepted]
PHST- 2012/11/10 06:00 [entrez]
PHST- 2012/11/10 06:00 [pubmed]
PHST- 2014/01/23 06:00 [medline]
AID - 10.1007/s11948-012-9412-5 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Sep;19(3):851-74. doi: 10.1007/s11948-012-9412-5. Epub 2012 
      Nov 9.


PMID- 23138090
OWN - NLM
STAT- MEDLINE
DCOM- 20130423
LR  - 20121109
IS  - 0926-9630 (Print)
IS  - 0926-9630 (Linking)
VI  - 182
DP  - 2012
TI  - Towards an international electronic repository and virtual laboratory of open
      data and open-source software for telehealth research: comparison of
      international, Australian and Finnish privacy policies.
PG  - 153-60
AB  - Health data includes all content related to health in all data formats, document 
      types, information systems, publication media and languages from all specialties,
      organisations, regions, states and countries. Capabilities to share, integrate
      and compare these data contents, clinical trial results and other evaluation
      outcomes together with telehealth applications for data processing are critical
      to accelerate discovery and its diffusion to clinical practice. However, the same
      ethical and legal frameworks that protect privacy hinder this open data and
      open-source code approach and the issues accumulate if moving data across
      national, regional or organisational borders. This can be seen as one of the
      reasons why many telehealth applications and health-research findings tend to be 
      limited to very narrow domains and global results are lacking. The aim of this
      paper is to take steps towards establishing an international electronic
      repository and virtual laboratory of open data and open-source code for research 
      purposes by comparing international, Australian and Finnish frameworks. The
      frameworks seem to be fundamentally similar; they apply the principles of
      accountability and adequacy to using and disclosing personal data. Their
      requirements to inform data subjects about the purposes of data collection and
      use before the dataset is collected, assure that individuals are no longer
      identifiable and to destruct data when the research activities are finished make 
      sharing data and even secondary data difficult. Using the Internet or cloud
      services for sharing without proper approvals by ethics committees is technically
      not allowed if the data are stored in another country. The research community
      needs to overcome these barriers and develop a virtual laboratory, which operates
      on distributed data repositories. This empowers the community by enabling
      systematic evaluations of new technologies and research hypotheses on a rich
      variety of data and against existing applications, and subsequent tracking of
      quality improvements in time.
FAU - Suominen, Hanna
AU  - Suominen H
AD  - NICTA, National ICT, Australia. Hanna.Suominen@nicta.com.au
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Stud Health Technol Inform
JT  - Studies in health technology and informatics
JID - 9214582
MH  - Australia
MH  - *Confidentiality
MH  - Data Collection/methods
MH  - Data Mining
MH  - Finland
MH  - Humans
MH  - Information Dissemination/*methods
MH  - Information Systems/*organization & administration
MH  - *International Cooperation
MH  - Telemedicine/*organization & administration
EDAT- 2012/11/10 06:00
MHDA- 2013/04/24 06:00
CRDT- 2012/11/10 06:00
PHST- 2012/11/10 06:00 [entrez]
PHST- 2012/11/10 06:00 [pubmed]
PHST- 2013/04/24 06:00 [medline]
PST - ppublish
SO  - Stud Health Technol Inform. 2012;182:153-60.


PMID- 23138023
OWN - NLM
STAT- MEDLINE
DCOM- 20130426
LR  - 20161125
IS  - 1600-0455 (Electronic)
IS  - 0284-1851 (Linking)
VI  - 54
IP  - 2
DP  - 2013 Mar 1
TI  - Whole spine CT for evaluation of scoliosis in children: feasibility of
      sub-milliSievert scanning protocol.
PG  - 226-30
LID - 10.1258/ar.2012.110625 [doi]
AB  - BACKGROUND: Optimization of CT radiation dose is important for children due to
      their higher risk of radiation-induced adverse effects. Anatomical structures
      with high inherent contrast, such as bones can be imaged at very low radiation
      doses by optimizing scan parameters. PURPOSE: To assess feasibility of
      sub-milliSievert whole spine CT scanning protocol for evaluation of scoliosis in 
      children. MATERIAL AND METHODS: With approval of the ethical board, we performed 
      whole spine CT for evaluation of scoliosis in 22 children (age range, 3-18 years;
      mean age, 13 years; 13 girls, 9 boys) on a 128-slice dual source
      multidetector-row CT scanner. Lowest possible quality reference mAs value (image 
      quality factor for xy-z automatic exposure control or xyz-AEC, CARE Dose 4D) was 
      selected on a per patient basis. Remaining parameters were held constant at 3.0:1
      pitch, 128 x 0.6 mm detector collimation, 115.2 mm table feed per gantry
      rotation, 100 kVp, and 1 and 3 mm reconstructed sections. Average mAs, projected 
      estimated dose savings with AEC, computed tomography dose index volume (CTDI
      vol), and dose length product (DLP) were recorded. Artifacts were graded on a
      four-point scale (1, no artifacts; 4, severe artifacts). Ability to identify
      vertebral and pedicular contours, and measure pedicular width and degree of
      vertebral rotation was graded on a three-point scale (1, unacceptable; 3,
      excellent). RESULTS: All CT examinations were deemed as reliable for identifying 
      vertebral and pedicular contours as well as for measuring pedicular width (5.9
      +/- 1.6 mm) and degree of vertebral rotation (28.7 +/- 23.4 degrees ). Mean
      objective image noise and signal to noise ratio (SNR) were 57.5 +/- 21.5 and 4.7 
      +/- 2.3, respectively. With a mean quality reference mAs of 13, the scanner
      employed an average actual effective mAs of 10 +/- 3.8 (range, 6-18 mAs) with an 
      estimated radiation dose saving of 43.5 +/- 16.3% with xyz-AEC compared with
      fixed mAs. The mean CTDI, DLP, and estimated effective doses were 0.4 +/- 0.1 mGy
      (0.2-0.7 mGy), 21 +/- 10 mGy.cm (8-41 mGy.cm), and 0.3 +/- 0.1 mSv (0.12-0.64
      mSv), respectively. CONCLUSION: Radiation dose for whole spine CT for evaluation 
      of scoliosis in children can be minimized to less than one-third of a
      milliSievert while maintaining diagnostic image quality.
FAU - Kalra, Mannudeep K
AU  - Kalra MK
AD  - Center for Medical Image Science and Visualization (CMIV), Linkoping University, 
      Linkoping University Hospital, Linkoping, Sweden.
FAU - Quick, Petter
AU  - Quick P
FAU - Singh, Sarabjeet
AU  - Singh S
FAU - Sandborg, Michael
AU  - Sandborg M
FAU - Persson, Anders
AU  - Persson A
LA  - eng
PT  - Journal Article
DEP - 20121108
PL  - England
TA  - Acta Radiol
JT  - Acta radiologica (Stockholm, Sweden : 1987)
JID - 8706123
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Kyphosis/diagnostic imaging
MH  - Male
MH  - Multidetector Computed Tomography/*methods
MH  - *Radiation Dosage
MH  - Scoliosis/*diagnostic imaging
MH  - Spine/*diagnostic imaging
EDAT- 2012/11/10 06:00
MHDA- 2013/04/27 06:00
CRDT- 2012/11/10 06:00
PHST- 2012/11/10 06:00 [entrez]
PHST- 2012/11/10 06:00 [pubmed]
PHST- 2013/04/27 06:00 [medline]
AID - ar.2012.110625 [pii]
AID - 10.1258/ar.2012.110625 [doi]
PST - ppublish
SO  - Acta Radiol. 2013 Mar 1;54(2):226-30. doi: 10.1258/ar.2012.110625. Epub 2012 Nov 
      8.


PMID- 23137787
OWN - NLM
STAT- MEDLINE
DCOM- 20131031
LR  - 20200320
IS  - 1469-5111 (Electronic)
IS  - 1461-1457 (Linking)
VI  - 16
IP  - 3
DP  - 2013 Apr
TI  - Risk counselling for family members in bipolar disorder and schizophrenia.
PG  - 713-4
LID - 10.1017/S1461145712001150 [doi]
AB  - In bipolar disorder (BD) and schizophrenia (SZ) rare and de novo chromosomal
      microdeletions and microduplications (CNVs) have strong effects on risk. For de
      novo CNVs, the risk of BD or SZ is 10% and for deletions of the q11 region on
      chromosome 22, the risk of either of these disorders is 77%. A not-insignificant 
      minority of BD and SZ patients have these types of event (4-6.5%).
      Psychotherapeutic intervention may be needed for within-family stigma and
      conflicts over genetic test results. These findings also raise ethical issues on 
      stigma prevention, population screening, and abortion based on genotype.
FAU - Gershon, Elliot S
AU  - Gershon ES
AD  - University of Chicago, Chicago, IL 60637, USA. egershon@yoda.bsd.uchicago.edu
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121109
PL  - England
TA  - Int J Neuropsychopharmacol
JT  - The international journal of neuropsychopharmacology
JID - 9815893
SB  - IM
MH  - Bipolar Disorder/diagnosis/*genetics/*psychology
MH  - Family/*psychology
MH  - Genetic Counseling/*methods/trends
MH  - Genome-Wide Association Study/trends
MH  - Humans
MH  - Risk Factors
MH  - Schizophrenia/diagnosis/*genetics
MH  - *Schizophrenic Psychology
EDAT- 2012/11/10 06:00
MHDA- 2013/11/01 06:00
CRDT- 2012/11/10 06:00
PHST- 2012/11/10 06:00 [entrez]
PHST- 2012/11/10 06:00 [pubmed]
PHST- 2013/11/01 06:00 [medline]
AID - S1461145712001150 [pii]
AID - 10.1017/S1461145712001150 [doi]
PST - ppublish
SO  - Int J Neuropsychopharmacol. 2013 Apr;16(3):713-4. doi: 10.1017/S1461145712001150.
      Epub 2012 Nov 9.


PMID- 23137244
OWN - NLM
STAT- MEDLINE
DCOM- 20131126
LR  - 20220316
IS  - 1466-187X (Electronic)
IS  - 0142-159X (Linking)
VI  - 35
IP  - 5
DP  - 2013 May
TI  - Mobile learning in resource-constrained environments: a case study of medical
      education.
PG  - e1157-65
LID - 10.3109/0142159X.2012.733454 [doi]
AB  - BACKGROUND: The achievement of the millennium development goals may be
      facilitated by the use of information and communication technology in medical and
      health education. AIMS: This study intended to explore the use and impact of
      educational technology in medical education in resource-constrained environments.
      METHODS: A multiple case study was conducted in two Nepalese teaching hospitals. 
      The data were analysed using activity theory as an analytical basis. RESULTS:
      There was little evidence for formal e-learning, but the findings indicate that
      students and residents adopted mobile technologies, such as mobile phones and
      small laptops, as cultural tools for surprisingly rich 'informal' learning in a
      very short time. These tools allowed learners to enhance (a) situated learning,
      by immediately connecting virtual information sources to their situated
      experiences; (b) cross-contextual learning by documenting situated experiences in
      the form of images and videos and re-using the material for later reflection and 
      discussion and (c) engagement with educational content in social network
      communities. CONCLUSION: By placing the students and residents at the centre of
      the new learning activities, this development has begun to affect the overall
      educational system. Leveraging these tools is closely linked to the development
      of broad media literacy, including awareness of ethical and privacy issues.
FAU - Pimmer, Christoph
AU  - Pimmer C
AD  - Institute for Information Systems, University of Applied Sciences, Northwestern
      Switzerland, Switzerland. christoph.pimmer@fhnw.ch
FAU - Linxen, Sebastian
AU  - Linxen S
FAU - Grohbiel, Urs
AU  - Grohbiel U
FAU - Jha, Anil Kumar
AU  - Jha AK
FAU - Burg, Gunter
AU  - Burg G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121108
PL  - England
TA  - Med Teach
JT  - Medical teacher
JID - 7909593
SB  - IM
MH  - *Cell Phone
MH  - *Computers, Handheld
MH  - Education, Distance/*methods
MH  - Hospitals, Teaching
MH  - Humans
MH  - *Internet
MH  - Learning
MH  - Nepal
EDAT- 2012/11/10 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/11/10 06:00
PHST- 2012/11/10 06:00 [entrez]
PHST- 2012/11/10 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.3109/0142159X.2012.733454 [doi]
PST - ppublish
SO  - Med Teach. 2013 May;35(5):e1157-65. doi: 10.3109/0142159X.2012.733454. Epub 2012 
      Nov 8.


PMID- 23137175
OWN - NLM
STAT- MEDLINE
DCOM- 20131122
LR  - 20141120
IS  - 1132-1989 (Print)
IS  - 1132-1989 (Linking)
VI  - 23
IP  - 78
DP  - 2012 May-Aug
TI  - [An approach to the legal and ethical problem of surrogate motherhood].
PG  - 253-67
AB  - Surrogate motherhood is an issue which currently gives rise to considerable
      complexity. Some consider that it is a justifiable practice which should be
      permitted by law. However, western legal systems have traditionally understood
      that whereas objects can be traded freely, persons, including the human body, its
      organs and most essential functions, cannot be the object of commerce. This means
      that the freedom of the individual to make contracts for mutual benefit is
      limited. Regarding the child, legalization of surrogate motherhood means
      converting the parent-child relationship into a commercial relationship, since in
      the last instance this would depend on a financial transaction. Moreover,
      experience has shown that the child is left in a very vulnerable position, since 
      his or her situation depends on the clauses set forth in the contract, which in
      no sense guarantees that his or her interests and rights will be protected. For
      all these reasons, we must conclude that the wish on the part of infertile
      couples should be taken seriously by society. However, not all desires that
      adults have should be regarded as rights, particularly if this is detrimental to 
      the dignity and rights of other subjects involved, particularly those of
      vulnerable women and their children.
FAU - Lopez Guzman, Jose
AU  - Lopez Guzman J
AD  - Universidad de Navarra, Campus Universitario, Pamplona, Espana. jlguzman@unav.es
FAU - Aparisi Miralles, Angela
AU  - Aparisi Miralles A
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Aproximacion a la Problematica Etica y Juridica de la Maternidad Subrogada.
PL  - Spain
TA  - Cuad Bioet
JT  - Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y
      Etica Medica
JID - 101312976
SB  - IM
MH  - *Bioethics
MH  - Child Advocacy/ethics/legislation & jurisprudence
MH  - *Commodification
MH  - Contracts/ethics/legislation & jurisprudence
MH  - Embryo Disposition/ethics/legislation & jurisprudence
MH  - Embryo Transfer/ethics
MH  - Female
MH  - Human Rights
MH  - Humans
MH  - Infant, Newborn
MH  - Insemination, Artificial, Heterologous/ethics/legislation & jurisprudence
MH  - Internet
MH  - Medical Tourism
MH  - Parents
MH  - Personal Autonomy
MH  - Pregnancy
MH  - Psychology, Child
MH  - *Surrogate Mothers/legislation & jurisprudence/psychology
EDAT- 2012/11/10 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/11/10 06:00
PHST- 2012/03/09 00:00 [received]
PHST- 2012/07/15 00:00 [accepted]
PHST- 2012/11/10 06:00 [entrez]
PHST- 2012/11/10 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
PST - ppublish
SO  - Cuad Bioet. 2012 May-Aug;23(78):253-67.


PMID- 23137085
OWN - NLM
STAT- MEDLINE
DCOM- 20130117
LR  - 20151119
IS  - 1538-957X (Electronic)
IS  - 1538-9588 (Linking)
VI  - 13
IP  - 6
DP  - 2012
TI  - In search of a standard for assessing the crash risk of driving under the
      influence of drugs other than alcohol; results of a questionnaire survey among
      researchers.
PG  - 554-65
LID - 10.1080/15389588.2012.663118 [doi]
AB  - OBJECTIVE: To find a gold standard for crash risk assessment studies in the field
      of driving under the influence of psychoactive substances. METHODS: A
      questionnaire survey on methodological aspects concerning study designs was sent 
      to researchers in the field of driving under the influence of psychoactive
      substances. The questionnaire was aimed at the 4 main study designs to assess the
      crash risk of driving under the influence: case-control studies, culpability
      studies, pharmaco-epidemiological studies, and experimental studies. RESULTS: The
      response rate for the questionnaire was 68 percent (N = 57). Forty-six percent of
      the respondents had a preference for assessing the crash risk by means of
      case-control studies, 35 percent by means of experimental studies, 14 percent by 
      means of culpability studies, and 5 percent by means of pharmaco-epidemiological 
      studies. In practice, however, only 51 percent of the researchers actually used
      the study type they preferred in theory. For the 4 most commonly used study
      designs, similarity rates varied from 66 to 81 percent for the theoretically
      preferred design and from 52 to 77 percent for the design that was actually
      applied. CONCLUSIONS: Based on the results of the questionnaire survey, it can be
      concluded that despite several attempts in the past to standardize study design, 
      there is still no common standard for assessing the crash risk of driving under
      the influence. The differences are not only caused by practical, legal,
      financial, or ethical issues but also by differences between researchers
      concerning their theoretically preferred study design.
FAU - Houwing, Sjoerd
AU  - Houwing S
AD  - SWOV Institute for Road Safety Research, Leidschendam, The Netherlands.
      sjoerd.houwing@swov.nl
FAU - Mathijssen, Rene
AU  - Mathijssen R
FAU - Brookhuis, Karel
AU  - Brookhuis K
LA  - eng
PT  - Journal Article
PL  - England
TA  - Traffic Inj Prev
JT  - Traffic injury prevention
JID - 101144385
SB  - IM
MH  - Accidents, Traffic/*statistics & numerical data
MH  - Automobile Driving/*statistics & numerical data
MH  - Humans
MH  - *Research Design
MH  - Research Personnel
MH  - Risk Assessment/standards
MH  - Substance-Related Disorders/*epidemiology
MH  - Surveys and Questionnaires
EDAT- 2012/11/10 06:00
MHDA- 2013/01/18 06:00
CRDT- 2012/11/10 06:00
PHST- 2012/11/10 06:00 [entrez]
PHST- 2012/11/10 06:00 [pubmed]
PHST- 2013/01/18 06:00 [medline]
AID - 10.1080/15389588.2012.663118 [doi]
PST - ppublish
SO  - Traffic Inj Prev. 2012;13(6):554-65. doi: 10.1080/15389588.2012.663118.


PMID- 23136354
OWN - NLM
STAT- MEDLINE
DCOM- 20130418
LR  - 20161125
IS  - 1542-6270 (Electronic)
IS  - 1060-0280 (Linking)
VI  - 46
IP  - 11
DP  - 2012 Nov
TI  - Stopping trials early for benefit--not so fast!
PG  - 1564-7
LID - 10.1345/aph.1Q780 [doi]
AB  - On October 25, 2011, Eli Lilly and Company announced the voluntary withdrawal of 
      Xigris (drotrecogin alfa [activated]) following the negative results of its most 
      recent clinical trial, the PROWESS-SHOCK study. The purpose of this commentary is
      to briefly review the history of drotrecogin alfa, discuss issues surrounding
      early cessation of clinical trials for benefit, and highlight the scientific and 
      ethical dilemmas faced when deciding whether or not to stop a trial early for
      benefit. This review should serve as an introduction to the topic of stopping
      trials early for benefit.
FAU - Faust, Andrew C
AU  - Faust AC
AD  - Department of Pharmacy, Texas Health Presbyterian Hospital Dallas. TX, USA.
      andrewfaust@texashealth.org
FAU - Chung, Tammy
AU  - Chung T
FAU - Feldman, Mark
AU  - Feldman M
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121107
PL  - United States
TA  - Ann Pharmacother
JT  - The Annals of pharmacotherapy
JID - 9203131
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Protein C)
RN  - 0 (Recombinant Proteins)
RN  - JGH8MYC891 (drotrecogin alfa activated)
SB  - IM
MH  - Anti-Infective Agents/*therapeutic use
MH  - Humans
MH  - Protein C/*therapeutic use
MH  - Randomized Controlled Trials as Topic
MH  - Recombinant Proteins/therapeutic use
MH  - Sepsis/*drug therapy
MH  - Treatment Outcome
EDAT- 2012/11/09 06:00
MHDA- 2013/04/20 06:00
CRDT- 2012/11/09 06:00
PHST- 2012/11/09 06:00 [entrez]
PHST- 2012/11/09 06:00 [pubmed]
PHST- 2013/04/20 06:00 [medline]
AID - aph.1Q780 [pii]
AID - 10.1345/aph.1Q780 [doi]
PST - ppublish
SO  - Ann Pharmacother. 2012 Nov;46(11):1564-7. doi: 10.1345/aph.1Q780. Epub 2012 Nov
      7.


PMID- 23135540
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130207
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 6
DP  - 2012
TI  - Challenges in implementing government-directed VTE guidance for medical patients:
      a mixed methods study.
LID - 10.1136/bmjopen-2012-001668 [doi]
LID - e001668 [pii]
AB  - BACKGROUND: Implementing venous thromboembolism (VTE) risk assessment guidance on
      admission to hospital has proved difficult worldwide. In 2010, VTE risk
      assessment in English hospitals was linked to financial sanctions. This study
      investigated possible barriers and facilitators for VTE risk assessment in
      medical patients and evaluated the impact of local and national initiatives.
      SETTING: Acute Medical Unit in one English National Health Service university
      teaching hospital. METHODS: This was a mixed methods study; National Research
      Ethics Service approval was granted. Data were collected over four 1-week
      periods; November 2009 (1), January 2010 (2), April 2010 (3) and April 2011 (4). 
      Case notes for all medical patients admitted during these periods were reviewed. 
      Thirty-six staff were observed admitting 71 of these patients; 24 observed staff 
      participated in a structured interview. RESULTS: 876 case notes were reviewed. In
      total, 82.1% of patients had one or more VTE risk factors and 25.3% one or more
      bleeding risks. VTE risk assessment rose from a baseline of 6.9-19.6%, following 
      local initiatives, and to 98.7% following financially sanctioned government
      targets. A similar increase in appropriate prescribing of prophylaxis was seen,
      but inappropriate prescribing also rose. No staff observed in period 1 conducted 
      VTE risk assessment, risk-assessment forms were largely ignored or discarded
      during period 2; and electronic recording systems available during period 3 were 
      not accessed. Few patients were asked any VTE-related questions in periods 1, 2
      or 3. Interviewees' actual knowledge of VTE risk was not related to perceived
      knowledge level. Eight of the 24 staff interviewed were aware of national
      policies or guidance: none had seen them. Principal barriers identified to risk
      assessment were: involvement of multiple staff in individual admissions;
      interruptions; lack of policy awareness; time pressure and complexity of tools.
      CONCLUSIONS: National financial sanctions appear effective in implementing
      guidance, where other local measures have failed.
FAU - Basey, Avril Janette
AU  - Basey AJ
AD  - Pharmacy Department, Royal Liverpool University Hospital, Liverpool, UK.
FAU - Krska, Janet
AU  - Krska J
FAU - Kennedy, Tom D
AU  - Kennedy TD
FAU - Mackridge, Adam John
AU  - Mackridge AJ
LA  - eng
PT  - Journal Article
DEP - 20121106
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3533008
EDAT- 2012/11/09 06:00
MHDA- 2012/11/09 06:01
CRDT- 2012/11/09 06:00
PHST- 2012/11/09 06:00 [entrez]
PHST- 2012/11/09 06:00 [pubmed]
PHST- 2012/11/09 06:01 [medline]
AID - bmjopen-2012-001668 [pii]
AID - 10.1136/bmjopen-2012-001668 [doi]
PST - epublish
SO  - BMJ Open. 2012 Nov 6;2(6). pii: bmjopen-2012-001668. doi:
      10.1136/bmjopen-2012-001668. Print 2012.


PMID- 23134959
OWN - NLM
STAT- MEDLINE
DCOM- 20130425
LR  - 20181202
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 92
IP  - 27
DP  - 2012 Jul 17
TI  - [Effects of dexmedetomidine combined with fentanyl in patients undergoing
      anesthesia induction by sevoflurane].
PG  - 1889-91
AB  - OBJECTIVE: To investigate the effects of dexmedetomidine combined with fentanyl
      in patients undergoing anesthesia induction by sevoflurane. METHOD: Eighty
      patients for elective endotracheal intubation under general anesthesia operations
      were randomly and double-blindly divided into Dex combined with fentanyl group
      (Group DF) and the fentanyl group (Group F) from April 2011 to September 2011 at 
      the Fourth Affiliated Hospital of Harbin Medical University, and there were 40
      cases in each group. The investigation was approved by all the patients and by
      the Ethics Committee of the hospital. In group DF, each patient was pumped in the
      0.5 microg/kg Dex by vein before 10 minutes of anesthesia induction and group F
      were given the same amount of normal saline, and tidal volume method was used to 
      induce anesthesia of sevoflurane. All the patients were given 2 microg/kg
      fentanyl and 0.1 mg/kg vecuronium by tracheal intubation and the MAP and HR and
      adverse reactions were observed before anesthesia induction (T(0)), before
      endotracheal intubation (T(1)), at the moment of tracheal intubation (T(2)),
      after 1 minutes of tracheal intubation (T(3)), after 3 minutes of tracheal
      intubation (T(4)) and after 5 minutes of tracheal intubation (T(5)). RESULT: The 
      loss of eyelash reflex time of group DF is shorter (P < 0.05), adverse reaction
      is less (P < 0.05) and the number of adding atropine case is higher than that of 
      group F (P < 0.05), the MAP of the two groups after induction of other moments
      are lower than that of T(0) (P < 0.05); MAP of group F at T(1) is lower than that
      of T(0), T(2), T(3) and group DF (P < 0.05); T(1) of group DF is lower than that 
      of T(0) (P < 0.05), the HR after induction of group DF is lower than that of T(0)
      and F group (P < 0.05), and that of T(2) and T(4) are higher than that of T(1) (P
      < 0.05); HR of group F at T(1) is lower than that of T(2) and T(3) (P < 0.05).
      CONCLUSION: Dexmedetomidine in combination with fentanyl can inhibit stress
      response of tracheal intubation of sevoflurane induction efficiently and
      stabilize hemodynamics.
FAU - Feng, Cui
AU  - Feng C
AD  - Department of Anesthesiology, Fourth Clinical College, Harbin Medical University,
      Harbin 150001, China.
FAU - Qi, Si-hua
AU  - Qi SH
FAU - Zou, Yu-mei
AU  - Zou YM
FAU - Ma, Xue-song
AU  - Ma XS
FAU - Gao, Da-peng
AU  - Gao DP
FAU - Han, Bao-qing
AU  - Han BQ
LA  - chi
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 0 (Adjuvants, Anesthesia)
RN  - 0 (Anesthetics, Inhalation)
RN  - 0 (Hypnotics and Sedatives)
RN  - 0 (Methyl Ethers)
RN  - 38LVP0K73A (Sevoflurane)
RN  - 67VB76HONO (Dexmedetomidine)
RN  - UF599785JZ (Fentanyl)
SB  - IM
MH  - Adjuvants, Anesthesia/*administration & dosage
MH  - Adult
MH  - Anesthesia, Inhalation
MH  - Anesthetics, Inhalation/*administration & dosage
MH  - Dexmedetomidine/*administration & dosage
MH  - Double-Blind Method
MH  - Female
MH  - Fentanyl/*administration & dosage
MH  - Hemodynamics/drug effects
MH  - Humans
MH  - Hypnotics and Sedatives/*administration & dosage
MH  - Intubation, Intratracheal
MH  - Male
MH  - Methyl Ethers/*administration & dosage
MH  - Middle Aged
MH  - Sevoflurane
MH  - Young Adult
EDAT- 2012/11/09 06:00
MHDA- 2013/04/26 06:00
CRDT- 2012/11/09 06:00
PHST- 2012/11/09 06:00 [entrez]
PHST- 2012/11/09 06:00 [pubmed]
PHST- 2013/04/26 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2012 Jul 17;92(27):1889-91.


PMID- 23134212
OWN - NLM
STAT- MEDLINE
DCOM- 20131202
LR  - 20220330
IS  - 1365-2702 (Electronic)
IS  - 0962-1067 (Linking)
VI  - 22
IP  - 7-8
DP  - 2013 Apr
TI  - The experiences of registered intellectual disability nurses caring for the older
      person with intellectual disability.
PG  - 1112-23
LID - 10.1111/jocn.12020 [doi]
AB  - AIM AND OBJECTIVES: To explore the experiences of registered intellectual
      disability nurses caring for the older person with intellectual disability.
      BACKGROUND: Increased longevity for the older person with intellectual disability
      is relatively a new phenomenon with social and medical factors having
      significantly increased the lifespan. The ageing population of people with
      intellectual disability is growing in Ireland, and they are outliving or expected
      to outlive their family carers. DESIGN: A qualitative Heideggerigan
      phenomenological approach allowed the researcher become immersed in the essence
      of meaning and analyse how registered intellectual disability nurses working with
      the older person perceive, experience and express their experience of caring.
      METHODS: After ethical approval was granted, data were collected through
      semi-structured interviews from seven participants and were transcribed and
      analysed thematically using Burnard's framework for data analysis. RESULTS: Three
      key themes were identified: 'care delivery', 'inclusiveness' and 'client-focused 
      care'. The study highlights the need for effective planning, an integrated
      approach to services and that the registered intellectual disability nurse needs 
      to be integrated into the care delivery system within the health service to
      support client and family carers in the home environment. CONCLUSIONS: Overall,
      the study shows the importance of teamwork, proactive planning, inclusion,
      attitudes, individualised care, knowing the person and best practice in providing
      care for older people with intellectual disability. RELEVANCE TO CLINICAL
      PRACTICE: This paper reports on the findings of a study which explored the
      experiences of caring for the older person with intellectual disability.
      Teamwork, proactive planning, client-centred approach and supporting clients
      living at home are important as ageing is inevitable.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - M Doody, Catriona
AU  - M Doody C
AD  - Daughters of Charity Service, Limerick, Ireland.
FAU - Markey, Kathleen
AU  - Markey K
FAU - Doody, Owen
AU  - Doody O
LA  - eng
PT  - Journal Article
DEP - 20121107
PL  - England
TA  - J Clin Nurs
JT  - Journal of clinical nursing
JID - 9207302
MH  - Aged
MH  - Humans
MH  - Intellectual Disability/*nursing
MH  - Nursing Staff/*psychology
MH  - Patient Care Team
EDAT- 2012/11/09 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/11/09 06:00
PHST- 2012/07/22 00:00 [accepted]
PHST- 2012/11/09 06:00 [entrez]
PHST- 2012/11/09 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1111/jocn.12020 [doi]
PST - ppublish
SO  - J Clin Nurs. 2013 Apr;22(7-8):1112-23. doi: 10.1111/jocn.12020. Epub 2012 Nov 7.


PMID- 23134094
OWN - NLM
STAT- MEDLINE
DCOM- 20130501
LR  - 20121108
IS  - 2042-7174 (Electronic)
IS  - 0961-7671 (Linking)
VI  - 20
IP  - 6
DP  - 2012 Dec
TI  - The influence of evidence-based medicine training on decision-making in relation 
      to over-the-counter medicines: a qualitative study.
PG  - 358-66
LID - 10.1111/j.2042-7174.2012.00220.x [doi]
AB  - OBJECTIVES: To explore the role of evidence of effectiveness when making
      decisions about over-the-counter (OTC) medication and to ascertain whether
      evidence-based medicine training raised awareness in decision-making.
      Additionally, this work aimed to complement the findings of a previous study
      because all participants in this current study had received training in
      evidence-based medicine (unlike the previous participants). METHODS: Following
      ethical approval and an e-mailed invitation, face-to-face, semi-structured
      interviews were conducted with newly registered pharmacists (who had received
      training in evidence-based medicine as part of their MPharm degree) to discuss
      the role of evidence of effectiveness with OTC medicines. Interviews were
      recorded and transcribed verbatim. Following transcription, all data were entered
      into the NVivo software package (version 8). Data were coded and analysed using a
      constant comparison approach. KEY FINDINGS: Twenty-five pharmacists (7 males and 
      18 females; registered for less than 4 months) were recruited and all
      participated in the study. Their primary focus with OTC medicines was safety;
      sales of products (including those that lack evidence of effectiveness) were
      justified provided they did no harm. Meeting patient expectation was also an
      important consideration and often superseded evidence. Despite knowledge of the
      concept, and an awareness of ethical requirements, an evidence-based approach was
      not routinely implemented by these pharmacists. Pharmacists did not routinely
      utilize evidence-based resources when making decisions about OTC medicines and
      some felt uncomfortable discussing the evidence-base for OTC products with
      patients. CONCLUSIONS: The evidence-based medicine training that these
      pharmacists received appeared to have limited influence on OTC decision-making.
      More work could be conducted to ensure that an evidence-based approach is
      routinely implemented in practice.
CI  - (c) 2012 The Authors. IJPP (c) 2012 Royal Pharmaceutical Society.
FAU - Hanna, Lezley-Anne
AU  - Hanna LA
AD  - School of Pharmacy, Queen's University Belfast, UK. l.hanna@qub.ac.uk
FAU - Hughes, Carmel
AU  - Hughes C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120614
PL  - England
TA  - Int J Pharm Pract
JT  - The International journal of pharmacy practice
JID - 9204243
RN  - 0 (Nonprescription Drugs)
SB  - IM
MH  - Data Collection
MH  - *Decision Making
MH  - Education, Pharmacy/methods
MH  - Evidence-Based Medicine/*education
MH  - Female
MH  - Humans
MH  - Male
MH  - Nonprescription Drugs/*administration & dosage/adverse effects
MH  - Pharmaceutical Services/organization & administration
MH  - Pharmacists/*organization & administration
EDAT- 2012/11/09 06:00
MHDA- 2013/05/02 06:00
CRDT- 2012/11/09 06:00
PHST- 2011/11/22 00:00 [received]
PHST- 2012/04/29 00:00 [accepted]
PHST- 2012/11/09 06:00 [entrez]
PHST- 2012/11/09 06:00 [pubmed]
PHST- 2013/05/02 06:00 [medline]
AID - 10.1111/j.2042-7174.2012.00220.x [doi]
PST - ppublish
SO  - Int J Pharm Pract. 2012 Dec;20(6):358-66. doi: 10.1111/j.2042-7174.2012.00220.x. 
      Epub 2012 Jun 14.


PMID- 23134051
OWN - NLM
STAT- MEDLINE
DCOM- 20160423
LR  - 20211021
IS  - 2168-3492 (Print)
IS  - 2168-3492 (Linking)
VI  - 34
IP  - 3
DP  - 2012
TI  - Alcohol Dependence and Genes Encoding alpha2 and gamma1 GABAA Receptor Subunits: 
      Insights from Humans and Mice.
PG  - 345-53
AB  - One approach to identifying the causes of alcoholism, particularly without
      crossing ethical boundaries in human subjects, is to look at the person's genome 
      (and particularly at the variations that naturally arise in the DNA) to identify 
      those variations that seem to be found more commonly in people with the disease. 
      Some of these analyses have focused on the genes that encode subunits of the
      receptor for the brain chemical (i.e., neurotransmitter) gamma-aminobutyric acid 
      (GABA). Different epidemiological genetic studies have provided evidence that
      variations in certain GABAA receptor (GABAA-R) subunits, particularly subunits
      alpha2 and gamma1, are correlated with alcohol dependence. Manipulations of these
      genes and their expression in mice and rats also are offering clues as to the
      role of specific GABAA-Rs in the molecular mechanisms underlying alcoholism and
      suggest possibilities for new therapeutic approaches.
FAU - Borghese, Cecilia M
AU  - Borghese CM
AD  - Waggoner Center for Alcohol and Addiction Research, University of Texas at
      Austin, Austin, Texas.
FAU - Harris, R Adron
AU  - Harris RA
LA  - eng
PT  - Editorial
PL  - United States
TA  - Alcohol Res
JT  - Alcohol research : current reviews
JID - 101594475
RN  - 0 (Receptors, GABA-A)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
SB  - IM
MH  - *Alcoholism/genetics
MH  - Animals
MH  - Brain/metabolism
MH  - Genome
MH  - Humans
MH  - Mice
MH  - *Receptors, GABA-A
MH  - gamma-Aminobutyric Acid
PMC - PMC3860398
EDAT- 2012/11/09 06:00
MHDA- 2016/04/24 06:00
CRDT- 2012/11/09 06:00
PHST- 2012/11/09 06:00 [entrez]
PHST- 2012/11/09 06:00 [pubmed]
PHST- 2016/04/24 06:00 [medline]
PST - ppublish
SO  - Alcohol Res. 2012;34(3):345-53.


PMID- 23132891
OWN - NLM
STAT- MEDLINE
DCOM- 20131210
LR  - 20220408
IS  - 1552-6801 (Electronic)
IS  - 1077-5587 (Linking)
VI  - 70
IP  - 1 Suppl
DP  - 2013 Feb
TI  - Conceptual, methodological, and ethical problems in communicating uncertainty in 
      clinical evidence.
PG  - 14S-36S
LID - 10.1177/1077558712459361 [doi]
AB  - The communication of uncertainty in clinical evidence is an important endeavor
      that poses difficult conceptual, methodological, and ethical problems. Conceptual
      problems include logical paradoxes in the meaning of probability and
      "ambiguity"--second-order uncertainty arising from the lack of reliability,
      credibility, or adequacy of probability information. Methodological problems
      include questions about optimal methods for representing fundamental
      uncertainties and for communicating these uncertainties in clinical practice.
      Ethical problems include questions about whether communicating uncertainty
      enhances or diminishes patient autonomy and produces net benefits or harms. This 
      article reviews the limited but growing literature on these problems and efforts 
      to address them and identifies key areas of focus for future research. It is
      argued that the critical need moving forward is for greater conceptual clarity
      and consistent representational methods that make the meaning of various
      uncertainties understandable, and for clinical interventions to support patients 
      in coping with uncertainty in decision making.
FAU - Han, Paul K J
AU  - Han PK
AD  - Center for Outcomes Research and Evaluation, Maine Medical Center, Portland, ME
      04101, USA. hanp@mmc.org
LA  - eng
GR  - Z99 HG999999/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20121106
PL  - United States
TA  - Med Care Res Rev
JT  - Medical care research and review : MCRR
JID - 9506850
SB  - IM
MH  - *Communication
MH  - Decision Making/ethics
MH  - Evidence-Based Medicine/ethics/standards
MH  - Humans
MH  - *Physician-Patient Relations/ethics
MH  - Probability
MH  - Uncertainty
PMC - PMC4238424
MID - NIHMS642655
EDAT- 2012/11/08 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/11/08 06:00
PHST- 2012/11/08 06:00 [entrez]
PHST- 2012/11/08 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 1077558712459361 [pii]
AID - 10.1177/1077558712459361 [doi]
PST - ppublish
SO  - Med Care Res Rev. 2013 Feb;70(1 Suppl):14S-36S. doi: 10.1177/1077558712459361.
      Epub 2012 Nov 6.


PMID- 23132871
OWN - NLM
STAT- MEDLINE
DCOM- 20140225
LR  - 20130329
IS  - 1464-360X (Electronic)
IS  - 1101-1262 (Linking)
VI  - 23
IP  - 2
DP  - 2013 Apr
TI  - An ethical framework for the prevention of overweight and obesity: a tool for
      thinking through a programme's ethical aspects.
PG  - 299-305
LID - 10.1093/eurpub/cks052 [doi]
AB  - INTRODUCTION: It is important to be aware of the ethical pitfalls in programmes
      to prevent overweight and obesity, such as stigmatization, blaming the victim and
      reinforcement of health inequalities. In this article, we present an ethical
      framework for facilitating a structured analysis to the extent to which a
      programme prevents overweight or obesity is ethically acceptable. METHODS: First,
      we made an inventory of ethical issues in programmes to prevent overweight and
      obesity. Secondly, we studied the available ethical frameworks that address the
      area of public health. Finally, we designed an ethical framework for the
      prevention of overweight and obesity, which was tested in two international
      workshops. RESULTS: At the heart of the framework is a list of eight questions on
      the morally relevant features of a programme: its effects on physical health,
      psychosocial well-being, informed choice, cultural values, equality, privacy,
      responsibility and liberty. Answering these questions provides a map of the
      potential ethical pitfalls of a specific programme. This mapping should be
      followed by a structured discussion of the arguments and their importance, and
      the decision whether, and if so under what conditions, the programme should be
      implemented. CONCLUSION: Considering the ethical aspects of the programmes to
      prevent obesity or overweight is extremely important in the face of the urgent
      and extensive health problem of overweight and obesity. Our framework is a
      practical tool for systematic ethical evaluation. It is applicable to a broad
      range of programmes in different stages of development and implementation.
FAU - Have, Marieke Ten
AU  - Have MT
AD  - 1 Department of Medical Ethics, Erasmus Medical Centre, Rotterdam, The
      Netherlands.
FAU - van der Heide, Agnes
AU  - van der Heide A
FAU - Mackenbach, Johan P
AU  - Mackenbach JP
FAU - de Beaufort, Inez D
AU  - de Beaufort ID
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120808
PL  - England
TA  - Eur J Public Health
JT  - European journal of public health
JID - 9204966
SB  - IM
MH  - Health Policy
MH  - Health Promotion/*ethics/*methods
MH  - Humans
MH  - Obesity/prevention & control
MH  - Overweight/*prevention & control
MH  - *Program Development
MH  - Program Evaluation
MH  - Public Health/ethics
EDAT- 2012/11/08 06:00
MHDA- 2014/02/26 06:00
CRDT- 2012/11/08 06:00
PHST- 2012/11/08 06:00 [entrez]
PHST- 2012/11/08 06:00 [pubmed]
PHST- 2014/02/26 06:00 [medline]
AID - cks052 [pii]
AID - 10.1093/eurpub/cks052 [doi]
PST - ppublish
SO  - Eur J Public Health. 2013 Apr;23(2):299-305. doi: 10.1093/eurpub/cks052. Epub
      2012 Aug 8.


PMID- 23132285
OWN - NLM
STAT- MEDLINE
DCOM- 20130605
LR  - 20121220
IS  - 1464-3804 (Electronic)
IS  - 0267-8357 (Linking)
VI  - 28
IP  - 1
DP  - 2013 Jan
TI  - In vitro cell transformation assays for an integrated, alternative assessment of 
      carcinogenicity: a data-based analysis.
PG  - 107-16
LID - 10.1093/mutage/ges059 [doi]
AB  - The study of the chemical carcinogenesis mechanisms and the design of efficient
      prevention strategies and measures are of crucial importance to protect human
      health. The long-term carcinogenesis bioassays have played a central role in
      protecting human health, but for ethical and practical reasons their use is
      dramatically diminishing, and the genotoxicity short-term tests have taken the
      pivotal role in the pre-screening of carcinogenicity. However, there is evidence 
      that this strategy is not sensitive enough to detect all genotoxic carcinogens
      and it cannot detect nongenotoxic carcinogens. In a previous article, we have
      shown that an integrated strategy consisting of the in vitro Ames and Syrian
      Hamster Embryo cells transformation assays, combined with structure-activity
      relationships, is a valid alternative to the present pre-screening strategies.
      Here, we expand the previous investigation by (i) including results of cell
      transformation assays on inorganics, together with an additional assay (Bhas 42),
      and (ii) considering new structural alerts for nongenotoxic carcinogenicity. We
      also present a new analysis on global relationships between toxicological
      endpoints. The new results confirm that the previously proposed integrated,
      alternative strategy is an efficient tool to identify both genotoxic and
      nongenotoxic carcinogens, with an estimated 90-95% sensitivity.
FAU - Benigni, Romualdo
AU  - Benigni R
AD  - Environment and Health Department, Istituto Superiore di Sanita', Viale Regina
      Elena 299, 00161 Rome, Italy. romualdo.benigni@iss.it
FAU - Bossa, Cecilia
AU  - Bossa C
FAU - Tcheremenskaia, Olga
AU  - Tcheremenskaia O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121106
PL  - England
TA  - Mutagenesis
JT  - Mutagenesis
JID - 8707812
RN  - 0 (Carcinogens)
SB  - IM
MH  - Animals
MH  - Carcinogenicity Tests/*methods
MH  - Carcinogens/*chemistry/*toxicity
MH  - Cell Line, Transformed
MH  - Cricetinae
MH  - Embryo, Mammalian/cytology/drug effects
MH  - Mesocricetus
MH  - Rodentia
MH  - Statistics as Topic/methods
EDAT- 2012/11/08 06:00
MHDA- 2013/06/06 06:00
CRDT- 2012/11/08 06:00
PHST- 2012/11/08 06:00 [entrez]
PHST- 2012/11/08 06:00 [pubmed]
PHST- 2013/06/06 06:00 [medline]
AID - ges059 [pii]
AID - 10.1093/mutage/ges059 [doi]
PST - ppublish
SO  - Mutagenesis. 2013 Jan;28(1):107-16. doi: 10.1093/mutage/ges059. Epub 2012 Nov 6.


PMID- 23132105
OWN - NLM
STAT- MEDLINE
DCOM- 20140106
LR  - 20151119
IS  - 1947-3613 (Electronic)
IS  - 1937-0660 (Linking)
VI  - 5
IP  - 4
DP  - 2012 Fall
TI  - Ethical obligations under New Jersey's mandated pharmaceutical disclosures.
PG  - 26-8
FAU - Schoppmann, Michael J
AU  - Schoppmann MJ
AD  - Kern Augustine Conroy & Schoppmann, P.C., USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - MD Advis
JT  - MD advisor : a journal for New Jersey medical community
JID - 101522608
SB  - IM
MH  - Disclosure/ethics/*legislation & jurisprudence
MH  - Documentation
MH  - Drug Industry/economics
MH  - Drug Prescriptions
MH  - Humans
MH  - New Jersey
MH  - Physicians/economics/*ethics
MH  - Practice Patterns, Physicians'/*ethics
EDAT- 2012/11/08 06:00
MHDA- 2014/01/07 06:00
CRDT- 2012/11/08 06:00
PHST- 2012/11/08 06:00 [entrez]
PHST- 2012/11/08 06:00 [pubmed]
PHST- 2014/01/07 06:00 [medline]
PST - ppublish
SO  - MD Advis. 2012 Fall;5(4):26-8.


PMID- 23131895
OWN - NLM
STAT- MEDLINE
DCOM- 20130429
LR  - 20211021
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 3
DP  - 2013 Mar
TI  - Institution animal care and use committees need greater ethical diversity.
PG  - 188-90
LID - 10.1136/medethics-2012-100982 [doi]
AB  - In response to public outrage stemming from exposes of animal abuse in research
      laboratories, the US Congress in 1985 mandated Institutional Animal Care and Use 
      Committees (IACUCs) to oversee animal use at institutions receiving federal
      grants. IACUCs were enjoined to respect public concern about the treatment of
      animals in research, but they were not specifically instructed whether or not to 
      perform ethical cost-benefit analyses of animal research protocols that IACUCs
      have chosen, with approval contingent upon a balancing of animal pain and
      suffering against a reasonable expectation of resultant human benefit. IACUCs
      have chosen not to make such ethical judgments but, rather, restrict themselves
      to an advisory role, often tweaking the details of animal-use protocols, but
      eventually approving all of them. This disinclination by IACUCs to take a broader
      ethical view of their authority and responsibilities may reflect a membership
      composition highly skewed towards animal researchers themselves (67%) and
      institutional veterinarians (15%), both with vested interests in continuing
      animal research. The resultant ethical monoculture may impair IACUC's ability to 
      meet public concern for laboratory animal welfare. Psychological research has
      established that unconscious bias affects us all, that deliberations among the
      like-minded lead to adapting extremist positions, and that groupthink blinds
      organisations to alternatives that might be obvious to outsiders. Taken together,
      skewed IACUC membership composition and psychological research insights into
      unconscious bias and groupthink suggest that an infusion of ethical diversity by 
      increasing the percentage of institutionally unaffiliated members on IACUCs would
      broaden their ethical perspectives and enable them to better address public
      concerns about laboratory animal welfare.
FAU - Hansen, Lawrence Arthur
AU  - Hansen LA
AD  - Department of Neurosciences and Pathology, University of California San Diego, La
      Jolla, CA 92093-0624, USA. lahansen@ucsd.edu
LA  - eng
PT  - Journal Article
DEP - 20121106
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Animal Care Committees/legislation & jurisprudence/organization &
      administration/trends
MH  - Animal Experimentation/*ethics
MH  - Animal Welfare/*ethics
MH  - Animals
MH  - *Animals, Laboratory
MH  - *Bias
MH  - *Decision Making
MH  - Dissent and Disputes
MH  - Ethics, Research
MH  - Humans
MH  - Pain/etiology
MH  - Professional Competence
MH  - Public Opinion
MH  - Research Personnel/*psychology
MH  - Stress, Psychological/etiology
MH  - Sweden
MH  - United States
PMC - PMC3595150
EDAT- 2012/11/08 06:00
MHDA- 2013/04/30 06:00
CRDT- 2012/11/08 06:00
PHST- 2012/11/08 06:00 [entrez]
PHST- 2012/11/08 06:00 [pubmed]
PHST- 2013/04/30 06:00 [medline]
AID - medethics-2012-100982 [pii]
AID - 10.1136/medethics-2012-100982 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Mar;39(3):188-90. doi: 10.1136/medethics-2012-100982. Epub
      2012 Nov 6.


PMID- 23131864
OWN - NLM
STAT- MEDLINE
DCOM- 20140321
LR  - 20211021
IS  - 1432-198X (Electronic)
IS  - 0931-041X (Linking)
VI  - 28
IP  - 10
DP  - 2013 Oct
TI  - The evolving ethics of infant dialysis.
PG  - 1943-7
LID - 10.1007/s00467-012-2351-1 [doi]
AB  - In this paper, we review ethical issues that arise when families and doctors face
      clinical decisions about renal replacement therapy for an infant with end-stage
      renal disease (ESRD). Over the last 20 years, many centers have begun to
      routinely offer renal replacement therapy. However, doctors and nurses both
      continue to view such therapy as optional, rather than mandatory. We speculate
      that the burdens of therapy on the family, and the uncertainties about
      satisfactory outcomes have led to a situation in which renal replacement therapy 
      remains desirable, but non-obligatory. We discuss the reasons why this is likely 
      to remain so, and the ways in which renal replacement therapy for infants with
      ESRD is similar to, or different from, other clinical situations in pediatrics.
      Finally, we propose a research agenda to answer questions that are crucial to
      making good ethical decisions about infant dialysis.
FAU - Lantos, John D
AU  - Lantos JD
AD  - Children's Mercy Hospital, University of Missouri, 2401 Gillham Road, Kansas
      City, MO 64108, USA. jlantos@cmh.edu
FAU - Warady, Bradley A
AU  - Warady BA
LA  - eng
GR  - KL2 RR033177/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20121107
PL  - Germany
TA  - Pediatr Nephrol
JT  - Pediatric nephrology (Berlin, Germany)
JID - 8708728
SB  - IM
MH  - Age Factors
MH  - Attitude of Health Personnel
MH  - Child Health Services/*ethics
MH  - Decision Support Techniques
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Judgment
MH  - Kidney Failure, Chronic/diagnosis/*therapy
MH  - Moral Obligations
MH  - Patient Selection/*ethics
MH  - Renal Dialysis/adverse effects/*ethics
MH  - Risk Assessment
MH  - Risk Factors
MH  - Treatment Outcome
PMC - PMC3626731
MID - NIHMS420021
EDAT- 2012/11/08 06:00
MHDA- 2014/03/22 06:00
CRDT- 2012/11/08 06:00
PHST- 2012/08/22 00:00 [received]
PHST- 2012/10/03 00:00 [accepted]
PHST- 2012/10/02 00:00 [revised]
PHST- 2012/11/08 06:00 [entrez]
PHST- 2012/11/08 06:00 [pubmed]
PHST- 2014/03/22 06:00 [medline]
AID - 10.1007/s00467-012-2351-1 [doi]
PST - ppublish
SO  - Pediatr Nephrol. 2013 Oct;28(10):1943-7. doi: 10.1007/s00467-012-2351-1. Epub
      2012 Nov 7.


PMID- 23131701
OWN - NLM
STAT- MEDLINE
DCOM- 20130522
LR  - 20220409
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 20
IP  - 2
DP  - 2013 Mar
TI  - Ethical decision-making and professional behaviour among nurses: a correlational 
      study.
PG  - 200-12
LID - 10.1177/0969733012455562 [doi]
AB  - This study examined the relationship between nurses' ethical decision-making
      levels and their professional behaviours. Data were collected from 225 nurses who
      were recruited from university hospitals in Ankara using proportionate sampling. 
      Data were analysed using descriptive statistics and Pearson correlations. Most of
      the nurses were familiar with ethical dilemmas in nursing practice. The Nursing
      Principled Thinking level was above average, while the Practical Consideration
      level was average. Nurses' professionalism level was low. There was a positive
      but weak correlation between professional behaviours of the nurses and their
      ethical decision-making levels. Increasing nurses' professionalism level can
      provide a positive contribution to the ethical decision-making level.
FAU - Cerit, Birgul
AU  - Cerit B
AD  - Bolu Health School, Abant Izzet Baysal University, 14280/Bolu, Turkey.
      birgulcerit@yahoo.com.tr
FAU - Dinc, Leyla
AU  - Dinc L
LA  - eng
PT  - Journal Article
DEP - 20121106
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - *Decision Making
MH  - Humans
MH  - *Nurses
EDAT- 2012/11/08 06:00
MHDA- 2013/05/23 06:00
CRDT- 2012/11/08 06:00
PHST- 2012/11/08 06:00 [entrez]
PHST- 2012/11/08 06:00 [pubmed]
PHST- 2013/05/23 06:00 [medline]
AID - 0969733012455562 [pii]
AID - 10.1177/0969733012455562 [doi]
PST - ppublish
SO  - Nurs Ethics. 2013 Mar;20(2):200-12. doi: 10.1177/0969733012455562. Epub 2012 Nov 
      6.


PMID- 23131700
OWN - NLM
STAT- MEDLINE
DCOM- 20130522
LR  - 20220409
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 20
IP  - 2
DP  - 2013 Mar
TI  - Dignity in care in the clinical setting: a narrative review.
PG  - 168-77
LID - 10.1177/0969733012458609 [doi]
AB  - This review aimed to explore nursing literature and research on dignity in care
      of inpatients and to evaluate how the care patients received in the hospital
      setting was related to perceived feelings of being dignified or undignified.
      Studies conducted between 2000 and 2010 were considered, using Cumulative Index
      to Nursing and Allied Health Literature and MEDLINE, and the search terms
      'patient dignity', 'dignity in care', 'human dignity and nursing' and 'dignity
      and nursing ethics'. Findings revealed, from the perspectives of nurses and
      patients, that dignity in care in the hospital setting is seen to be influenced
      by physical environment, staff attitude and behaviour, organisational culture and
      patient independence. This review can help nurses to better understand dignity in
      care, and for policy makers, there are implications about determining the
      physical environment, staff attitude and behaviour and organisational culture
      needed to promote patient dignity in nursing. By identifying the most important
      factors from patients' and nurses' perspectives that contribute to dignity in
      care, nursing interventions, such as campaigns and education in clinical
      practice, can be developed.
FAU - Lin, Yea-Pyng
AU  - Lin YP
AD  - Mennonite Christian Hospital, Taiwan.
FAU - Watson, Roger
AU  - Watson R
FAU - Tsai, Yun-Fang
AU  - Tsai YF
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121106
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Humans
MH  - *Nursing Homes
MH  - *Right to Die
EDAT- 2012/11/08 06:00
MHDA- 2013/05/23 06:00
CRDT- 2012/11/08 06:00
PHST- 2012/11/08 06:00 [entrez]
PHST- 2012/11/08 06:00 [pubmed]
PHST- 2013/05/23 06:00 [medline]
AID - 0969733012458609 [pii]
AID - 10.1177/0969733012458609 [doi]
PST - ppublish
SO  - Nurs Ethics. 2013 Mar;20(2):168-77. doi: 10.1177/0969733012458609. Epub 2012 Nov 
      6.


PMID- 23131685
OWN - NLM
STAT- MEDLINE
DCOM- 20131210
LR  - 20121107
IS  - 1539-0713 (Electronic)
IS  - 0884-741X (Linking)
VI  - 30
IP  - 10
DP  - 2012 Nov-Dec
TI  - An orthodox perspective of the Jewish end-of-life experience.
PG  - 579-85
LID - 10.1097/NHH.0b013e3182705c60 [doi]
AB  - This article provides insight into Jewish law, ethics, and cultural practices
      regarding pain management, care of the dying Jewish patient, and Jewish rituals
      after death across the care continuum. Clinically and culturally appropriate care
      provision is important in the setting of a hospital, nursing home, and community 
      dwelling because of deep religious belief and practices, as well as life
      experiences such as the Holocaust. The recognition of deep spiritual and cultural
      practices from the interdisciplinary or interprofessional team serves to fulfill 
      a holistic approach to the overall care of the patient and family.
FAU - Prosser, Regina
AU  - Prosser R
AD  - Montefiore/Montefiore at Home/Vinney Hospice and Palliative Care, Beachwood, OH
      44122, USA. gprosser@montefiorecare.org
FAU - Korman, Diane
AU  - Korman D
FAU - Feinstein, Rabbi Akiva
AU  - Feinstein RA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Home Healthc Nurse
JT  - Home healthcare nurse
JID - 8403379
MH  - Assisted Living Facilities
MH  - Attitude to Death/ethnology
MH  - Culture
MH  - Family/ethnology
MH  - Humans
MH  - Jews/*ethnology
MH  - Pain Management
MH  - *Terminal Care
MH  - Terminally Ill
EDAT- 2012/11/08 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/11/08 06:00
PHST- 2012/11/08 06:00 [entrez]
PHST- 2012/11/08 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1097/NHH.0b013e3182705c60 [doi]
AID - 00004045-201211000-00004 [pii]
PST - ppublish
SO  - Home Healthc Nurse. 2012 Nov-Dec;30(10):579-85. doi:
      10.1097/NHH.0b013e3182705c60.


PMID- 23131529
OWN - NLM
STAT- MEDLINE
DCOM- 20130522
LR  - 20211021
IS  - 1873-4898 (Electronic)
IS  - 1477-5131 (Linking)
VI  - 8
IP  - 6
DP  - 2012 Dec
TI  - Prenatal management of disorders of sex development.
PG  - 576-84
LID - 10.1016/j.jpurol.2012.10.012 [doi]
LID - S1477-5131(12)00248-3 [pii]
AB  - Disorders of sex development (DSD) rarely present prenatally but, as they are
      very complex conditions, management should be directed by highly specialised
      medical teams to allow consideration of all aspects of diagnosis, treatment and
      ethical issues. In this brief review, we present an overview of the prenatal
      presentation and management of DSD, including the sonographic appearance of
      normal genitalia and methods of determining genetic sex, the prenatal management 
      of pregnancies with the unexpected finding of genital ambiguity on prenatal
      ultrasound and a review of the prenatal management of pregnancies at high risk of
      DSD. As this is a rapidly developing field, management options will change over
      time, making the involvement of clinical geneticists, paediatric endocrinologists
      and urologists, as well as fetal medicine specialists, essential in the care of
      these complex pregnancies. The reader should also bear in mind that local social,
      ethical and legal aspects may also influence management.
CI  - Copyright (c) 2012 Journal of Pediatric Urology Company. All rights reserved.
FAU - Chitty, Lyn S
AU  - Chitty LS
AD  - Clinical and Molecular Genetics Unit, UCL Institute of Child Health, London, UK. 
      l.chitty@ucl.ac.uk
FAU - Chatelain, Pierre
AU  - Chatelain P
FAU - Wolffenbuttel, Katja P
AU  - Wolffenbuttel KP
FAU - Aigrain, Yves
AU  - Aigrain Y
LA  - eng
GR  - RP-PG-0707-10107/DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20121104
PL  - England
TA  - J Pediatr Urol
JT  - Journal of pediatric urology
JID - 101233150
SB  - IM
MH  - Adrenal Hyperplasia, Congenital/diagnostic imaging/genetics/therapy
MH  - Disorders of Sex Development/*diagnostic imaging/*genetics/therapy
MH  - Female
MH  - *Genetic Testing
MH  - Humans
MH  - Male
MH  - Pregnancy
MH  - Prenatal Care/methods
MH  - *Sex Determination Analysis
MH  - *Ultrasonography, Prenatal
EDAT- 2012/11/08 06:00
MHDA- 2013/05/23 06:00
CRDT- 2012/11/08 06:00
PHST- 2012/10/10 00:00 [received]
PHST- 2012/10/10 00:00 [accepted]
PHST- 2012/11/08 06:00 [entrez]
PHST- 2012/11/08 06:00 [pubmed]
PHST- 2013/05/23 06:00 [medline]
AID - S1477-5131(12)00248-3 [pii]
AID - 10.1016/j.jpurol.2012.10.012 [doi]
PST - ppublish
SO  - J Pediatr Urol. 2012 Dec;8(6):576-84. doi: 10.1016/j.jpurol.2012.10.012. Epub
      2012 Nov 4.


PMID- 23131392
OWN - NLM
STAT- MEDLINE
DCOM- 20130730
LR  - 20200206
IS  - 1569-8041 (Electronic)
IS  - 0923-7534 (Linking)
VI  - 24
IP  - 3
DP  - 2013 Mar
TI  - Osteosarcomas of the mandible: multidisciplinary management of a rare tumor of
      the young adult a cooperative study of the GSF-GETO, Rare Cancer Network,
      GETTEC/REFCOR and SFCE.
PG  - 824-31
LID - 10.1093/annonc/mds507 [doi]
AB  - BACKGROUND: Mandibular osteosarcomas (MOS) mostly affect young adults. Their
      treatment is extrapolated from that of extragnathic osteosarcomas. MATERIAL AND
      METHODS: A retrospective multicooperative group study was conducted to determine 
      the impact of chemotherapy, adjuvant radiation therapy and surgery on outcomes
      and to identify prognostic factors. This ethical committee-approved study
      included a centralized review of histology slides and operative reports. RESULTS:
      Of 111 patients, 58.6% were male, median age 35 years (13%, </=18 years).
      Histology was osteoblastic, chondroblastic, fibroblastic, conventional not
      otherwise specified and others in 39.6%, 30.6%, 8.1%, 12.6% and 8.0%,
      respectively. Pathological World Health Organisation grades were low,
      intermediate and high grade in 6.4%, 11.8% and 81.8%, respectively. Surgery was
      carried out for 94.5% of patients. Neoadjuvant chemotherapy (mixed protocols) was
      carried out in 93.1% of patients. Postoperative chemotherapy and radiotherapy
      were carried out in 54.7% and 23.8%, respectively. Median follow-up was 59.6
      months (range). Five-year local control, metastasis-free, disease-free and
      overall survival rates were 64.6%, 68.9%, 53.2% and 69.2%, respectively. Survival
      was significantly associated with age, tumor size and surgery. Wide surgery with 
      clear margins and free flap reconstruction was the strongest prognostic factor.
      Neoadjuvant chemotherapy improved disease-free and metastatic-free survival and
      increased clear margins rates from 50% to 68%. Intermediate grades behaved like
      high grades in terms of metastatic-free and disease-free survival. CONCLUSION:
      This homogeneous series is the largest to date and emphasizes the major impact of
      clear margins and multidisciplinary management. Neoadjuvant chemotherapy improves
      disease-free survival and should be recommended for both high and intermediate
      grade MOS.
FAU - Thariat, J
AU  - Thariat J
AD  - Department of Radiation Oncology, Cancer Center Antoine-Lacassagne, Institut
      Universitaire de la Face et du Cou, University Nice Sophia-Antipolis, 06189- Nice
      Cedex 2, France. jthariat@hotmail.com
FAU - Schouman, T
AU  - Schouman T
FAU - Brouchet, A
AU  - Brouchet A
FAU - Sarini, J
AU  - Sarini J
FAU - Miller, R C
AU  - Miller RC
FAU - Reychler, H
AU  - Reychler H
FAU - Ray-Coquard, I
AU  - Ray-Coquard I
FAU - Italiano, A
AU  - Italiano A
FAU - Verite, C
AU  - Verite C
FAU - Sohawon, S
AU  - Sohawon S
FAU - Bompas, E
AU  - Bompas E
FAU - Dassonville, O
AU  - Dassonville O
FAU - Salas, S
AU  - Salas S
FAU - Aldabbagh, K
AU  - Aldabbagh K
FAU - Maingon, P
AU  - Maingon P
FAU - de La MotteRouge, T
AU  - de La MotteRouge T
FAU - Kurtz, J E
AU  - Kurtz JE
FAU - Usseglio, J
AU  - Usseglio J
FAU - Kerbrat, P
AU  - Kerbrat P
FAU - Raoul, G
AU  - Raoul G
FAU - Lotz, J P
AU  - Lotz JP
FAU - Bar-Sela, G
AU  - Bar-Sela G
FAU - Brugieres, L
AU  - Brugieres L
FAU - Chaigneau, L
AU  - Chaigneau L
FAU - Saada, E
AU  - Saada E
FAU - Odin, G
AU  - Odin G
FAU - Marcy, P Y
AU  - Marcy PY
FAU - Thyss, A
AU  - Thyss A
FAU - Julieron, M
AU  - Julieron M
LA  - eng
PT  - Journal Article
DEP - 20121106
PL  - England
TA  - Ann Oncol
JT  - Annals of oncology : official journal of the European Society for Medical
      Oncology
JID - 9007735
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - *Disease Management
MH  - Disease-Free Survival
MH  - Female
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Mandibular Neoplasms/mortality/pathology/*therapy
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Neoplasm Recurrence, Local/mortality/*prevention & control
MH  - Osteosarcoma/mortality/secondary/*therapy
MH  - Proportional Hazards Models
MH  - Retrospective Studies
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2012/11/08 06:00
MHDA- 2013/07/31 06:00
CRDT- 2012/11/08 06:00
PHST- 2012/11/08 06:00 [entrez]
PHST- 2012/11/08 06:00 [pubmed]
PHST- 2013/07/31 06:00 [medline]
AID - S0923-7534(19)37133-9 [pii]
AID - 10.1093/annonc/mds507 [doi]
PST - ppublish
SO  - Ann Oncol. 2013 Mar;24(3):824-31. doi: 10.1093/annonc/mds507. Epub 2012 Nov 6.


PMID- 23131157
OWN - NLM
STAT- MEDLINE
DCOM- 20130613
LR  - 20191027
IS  - 1996-3181 (Electronic)
IS  - 1871-5273 (Linking)
VI  - 11
IP  - 7
DP  - 2012 Nov 1
TI  - The role of platelets and their microparticles in rehabilitation of ischemic
      brain tissue.
PG  - 921-5
AB  - Stroke is a leading cause of mortality and chronic disability. Therapies aimed at
      reducing stroke related morbidity are currently limited. Therefore it is very
      important to develop effective treatments that will maximize rehabilitation after
      stroke. Current efforts in the field of cellular therapy focus on stem cell
      transplantations. This approach involves biological and ethical complications and
      therefore, the use of endogenous neural stem cells (eNSC) for repairing damage in
      various neurological disorders has been suggested. eNSCs reside in specialized
      vascular niches in defined regions, such as the subventricular zone (SVZ) of the 
      lateral ventricle. These cells have an unlimited potential to create newborn
      cells. Interrelations between newborn neural and endothelial cells have an
      important role in eNSC survival, maturation, migration and differentiation and
      neurogenesis occurs in close spatio-temporal association with vessel growth in
      these niches. Previous studies have shown that application of external factors
      can boost long-term endogenous repair mechanisms in the cerebral cortex.
      Activated platelets and their microparticles contain a variety of growth and
      trophic factors essential to angiogenesis and neurogenesis and may therefore
      serve as novel therapeutic agents for brain injury. Specifically, factors from
      platelets and their microparticles may promote neurogenesis by stimulating eNSC
      proliferation, migration and differentiation, and by stimulating niche
      angiogenesis and the release of neurogenic signals from endothelial cells and
      astrocytes. In this review we will show that combined augmentation of
      angiogenesis, neurogenesis and neuroprotection using platelets and their
      microparticles is feasible and results in improved functional gain after stroke.
FAU - Hayon, Yael
AU  - Hayon Y
AD  - Department of Neurology, Peritz and Chantal Scheinberg Cerebrovascular Research
      Laboratory, Hadassah Ein Kerem, Jerusalem, Israel.
FAU - Shai, Ela
AU  - Shai E
FAU - Varon, David
AU  - Varon D
FAU - Leker, Ronen R
AU  - Leker RR
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - CNS Neurol Disord Drug Targets
JT  - CNS & neurological disorders drug targets
JID - 101269155
RN  - 0 (Angiogenesis Inducing Agents)
RN  - 0 (Nerve Growth Factors)
SB  - IM
MH  - Angiogenesis Inducing Agents/metabolism/pharmacology/therapeutic use
MH  - Animals
MH  - Blood Platelets/*metabolism/pathology
MH  - Brain Ischemia/etiology/metabolism/pathology/*therapy
MH  - Cell-Derived Microparticles/*metabolism/pathology
MH  - Cerebral Cortex/blood supply/drug effects/*pathology/physiology
MH  - Drug Discovery
MH  - Embryonic Stem Cells/cytology/transplantation
MH  - Humans
MH  - Lateral Ventricles/cytology/embryology
MH  - Models, Biological
MH  - *Neovascularization, Physiologic/drug effects
MH  - Nerve Growth Factors/metabolism/pharmacology/therapeutic use
MH  - Nerve Regeneration/drug effects
MH  - Neural Stem Cells/cytology/transplantation
MH  - *Neurogenesis/drug effects
MH  - Neurons/drug effects/pathology/physiology
MH  - Platelet Activation
MH  - Stem Cell Niche
MH  - Stroke/physiopathology
MH  - *Stroke Rehabilitation
EDAT- 2012/11/08 06:00
MHDA- 2013/06/14 06:00
CRDT- 2012/11/08 06:00
PHST- 2012/06/12 00:00 [received]
PHST- 2012/07/06 00:00 [revised]
PHST- 2012/08/15 00:00 [accepted]
PHST- 2012/11/08 06:00 [entrez]
PHST- 2012/11/08 06:00 [pubmed]
PHST- 2013/06/14 06:00 [medline]
AID - CDTCNSND-EPUB-20121101-7 [pii]
AID - 10.2174/1871527311201070921 [doi]
PST - ppublish
SO  - CNS Neurol Disord Drug Targets. 2012 Nov 1;11(7):921-5. doi:
      10.2174/1871527311201070921.


PMID- 23131007
OWN - NLM
STAT- MEDLINE
DCOM- 20130306
LR  - 20211203
IS  - 1741-7015 (Electronic)
IS  - 1741-7015 (Linking)
VI  - 10
DP  - 2012 Nov 6
TI  - Is belief larger than fact: expectations, optimism and reality for translational 
      stem cell research.
PG  - 133
LID - 10.1186/1741-7015-10-133 [doi]
AB  - BACKGROUND: Stem cell (SC) therapies hold remarkable promise for many diseases,
      but there is a significant gulf between public expectations and the reality of
      progress toward clinical application. Public expectations are fueled by
      stakeholder arguments for research and public funding, coupled with intense media
      coverage in an ethically charged arena. We examine media representations in light
      of the expanding global landscape of SC clinical trials, asking what patients may
      realistically expect by way of timelines for the therapeutic and curative
      potential of regenerative medicine? METHODS: We built 2 international datasets:
      (1) 3,404 clinical trials (CT) containing 'stem cell*' from ClinicalTrials.gov
      and the World Health Organization's International Clinical Trials Registry Search
      Portal; and (2) 13,249 newspaper articles on SC therapies using Factiva.com. We
      compared word frequencies between the CT descriptions and full-text newspaper
      articles for the number containing terms for SC type and diseases/conditions. We 
      also developed inclusion and exclusion criteria to identify novel SC CTs, mainly 
      regenerative medicine applications. RESULTS: Newspaper articles focused on human 
      embryonic SCs and neurological conditions with significant coverage as well of
      cardiovascular disease and diabetes. In contrast, CTs used primarily
      hematopoietic SCs, with an increase in CTs using mesenchymal SCs since 2007. The 
      latter dominated our novel classification for CTs, most of which are in phases I 
      and II. From the perspective of the public, expecting therapies for neurological 
      conditions, there is limited activity in what may be considered novel
      applications of SC therapies. CONCLUSIONS: Given the research, regulatory, and
      commercialization hurdles to the clinical translation of SC research, it seems
      likely that patients and political supporters will become disappointed and
      disillusioned. In this environment, proponents need to make a concerted effort to
      temper claims. Even though the field is highly promising, it lacks significant
      private investment and is largely reliant on public support, requiring a more
      honest acknowledgement of the expected therapeutic benefits and the timelines to 
      achieving them.
FAU - Bubela, Tania
AU  - Bubela T
AD  - Department of Public Health Sciences, School of Public Health, Edmonton Clinic
      Health Academy, University of Alberta, Edmonton, Alberta, Canada.
      tbubela@ualberta.ca
FAU - Li, Matthew D
AU  - Li MD
FAU - Hafez, Mohamed
AU  - Hafez M
FAU - Bieber, Mark
AU  - Bieber M
FAU - Atkins, Harold
AU  - Atkins H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121106
PL  - England
TA  - BMC Med
JT  - BMC medicine
JID - 101190723
SB  - IM
MH  - Clinical Trials as Topic
MH  - *Culture
MH  - Humans
MH  - *Public Opinion
MH  - Regenerative Medicine/*trends
MH  - *Stem Cell Research
MH  - Translational Research, Biomedical/*trends
PMC - PMC3520764
EDAT- 2012/11/08 06:00
MHDA- 2013/03/07 06:00
CRDT- 2012/11/08 06:00
PHST- 2012/06/15 00:00 [received]
PHST- 2012/11/06 00:00 [accepted]
PHST- 2012/11/08 06:00 [entrez]
PHST- 2012/11/08 06:00 [pubmed]
PHST- 2013/03/07 06:00 [medline]
AID - 1741-7015-10-133 [pii]
AID - 10.1186/1741-7015-10-133 [doi]
PST - epublish
SO  - BMC Med. 2012 Nov 6;10:133. doi: 10.1186/1741-7015-10-133.


PMID- 23130972
OWN - NLM
STAT- MEDLINE
DCOM- 20130822
LR  - 20220129
IS  - 1747-4949 (Electronic)
IS  - 1747-4930 (Linking)
VI  - 8
IP  - 3
DP  - 2013 Apr
TI  - People with aphasia: capacity to consent, research participation and intervention
      inequalities.
PG  - 193-6
LID - 10.1111/j.1747-4949.2012.00900.x [doi]
AB  - Of 14 randomized controlled trials included in the recent Cochrane review of the 
      evidence relating to information provision after stroke, only one included people
      with aphasia with the remainder either excluding this patient sub-group (10/14
      trials) or failing to report any exclusion criteria. A third of people that
      experience a stroke will also experience aphasia, affecting their speaking,
      understanding, reading, and writing. The pervasive supposition that people with
      aphasia lack the capacity to make decisions for themselves is flawed and has the 
      potential to lead to inequalities in care. We highlight the degree to which
      people with aphasia have been excluded from full participation in some areas of
      stroke research and the potential clinical consequences of their systematic
      exclusion. We emphasize the clinical and ethical need for the provision of more
      accessible research information and consent processes, illustrate the feasibility
      of adopting such an approach, and consider the broader benefits to stroke
      research of inclusive and accessible research approaches.
CI  - (c) 2012 The Authors. International Journal of Stroke (c) 2012 World Stroke
      Organization.
FAU - Brady, Marian C
AU  - Brady MC
AD  - Nursing, Midwifery and Allied Health Professions Research Unit, Buchanan House,
      Glasgow Caledonian University, Glasgow, UK. m.brady@gcu.ac.uk
FAU - Fredrick, Alex
AU  - Fredrick A
FAU - Williams, Brian
AU  - Williams B
LA  - eng
GR  - NMAHP2/CSO_/Chief Scientist Office/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121106
PL  - United States
TA  - Int J Stroke
JT  - International journal of stroke : official journal of the International Stroke
      Society
JID - 101274068
SB  - IM
MH  - Aphasia/*psychology
MH  - Healthcare Disparities
MH  - Humans
MH  - Informed Consent/*psychology
MH  - Mental Competency/*psychology
MH  - Patient Selection
MH  - Presumed Consent
MH  - Randomized Controlled Trials as Topic
MH  - Stroke/*psychology
EDAT- 2012/11/08 06:00
MHDA- 2013/08/24 06:00
CRDT- 2012/11/08 06:00
PHST- 2012/11/08 06:00 [entrez]
PHST- 2012/11/08 06:00 [pubmed]
PHST- 2013/08/24 06:00 [medline]
AID - 10.1111/j.1747-4949.2012.00900.x [doi]
PST - ppublish
SO  - Int J Stroke. 2013 Apr;8(3):193-6. doi: 10.1111/j.1747-4949.2012.00900.x. Epub
      2012 Nov 6.


PMID- 23130746
OWN - NLM
STAT- MEDLINE
DCOM- 20131122
LR  - 20121107
IS  - 1132-1989 (Print)
IS  - 1132-1989 (Linking)
VI  - 23
IP  - 78
DP  - 2012 May-Aug
TI  - [About <<responsibility>> of vaccination].
PG  - 323-36
AB  - The debate over compulsory or merely recommended vaccination remains open, albeit
      latent, in those countries that have mandatory vaccine schedules. Despite the
      advantages of preventive immunization from the point of medical, economic and
      social features, it's clear, in the current status of medical ethics, that the
      exercise of patient autonomy calls for personal responsibility in the election of
      treatments and, in fact, the vaccines. Therefore, it is necessary to change the
      simple idea of prevention as <<risk reduction>>, characteristic of a <<third
      person ethic>> in order to pass to a preventative medicine concept that will be
      able to support the achievement of moral attitudes towards achieving the good
      <<health>> for the individual and for the community. This is only possible from a
      <<first person ethic>> wherever is possible to present an alternative between
      mandatory vs. recommendation from the concept of <<responsibility>> that, with
      the help of a series of measures, could combine the effective protection for the 
      whole community with the responsible exercise of the personal autonomy.
FAU - Di Pietro, Maria Luisa
AU  - Di Pietro ML
AD  - Assicurazioni, Istituto di Igiene, Italia. marialuisa.dipietro@gmail.com
FAU - Refolo, Pietro
AU  - Refolo P
FAU - Gonzalez-Melado, Fermin J
AU  - Gonzalez-Melado FJ
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Sobre la <<Responsabilidad>> de la Vacunacion.
PL  - Spain
TA  - Cuad Bioet
JT  - Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y
      Etica Medica
JID - 101312976
RN  - 0 (Vaccines)
SB  - IM
CIN - Cuad Bioet. 2013 Jan-Apr;24(80):127. PMID: 23898473
CIN - Cuad Bioet. 2013 Jan-Apr;24(80):127-9. PMID: 23898474
MH  - Altruism
MH  - Attitude to Health
MH  - Humans
MH  - Immunity, Herd
MH  - Mandatory Programs/ethics/legislation & jurisprudence
MH  - Motivation
MH  - Patient Acceptance of Health Care
MH  - Personal Autonomy
MH  - Preventive Medicine/ethics/legislation & jurisprudence
MH  - Public Health
MH  - Refusal to Participate/ethics/legislation & jurisprudence
MH  - Risk Reduction Behavior
MH  - *Social Responsibility
MH  - Social Values
MH  - Vaccination/*ethics/legislation & jurisprudence/trends
MH  - Vaccines/adverse effects
EDAT- 2012/11/08 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/11/08 06:00
PHST- 2011/12/19 00:00 [received]
PHST- 2012/03/04 00:00 [accepted]
PHST- 2012/11/08 06:00 [entrez]
PHST- 2012/11/08 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
PST - ppublish
SO  - Cuad Bioet. 2012 May-Aug;23(78):323-36.


PMID- 23130745
OWN - NLM
STAT- MEDLINE
DCOM- 20131122
LR  - 20140731
IS  - 1132-1989 (Print)
IS  - 1132-1989 (Linking)
VI  - 23
IP  - 78
DP  - 2012 May-Aug
TI  - [Preimplantatory genetic diagnosis and ''saviour sibling'': ethical criteria
      found in the biomedical and bioethics literature].
PG  - 301-20
AB  - UNLABELLED: A bibliographic review on <<saviour sibling>> was performed in order 
      to find out the ethical criteria put forward by the authors on this issue. 23
      biomedical and 10 bioethical journals were reviewed and authors for and against
      the procedure were found. In the Biomedical journals, the main arguments for this
      issue are that nobody should be hurt and that there is an ethical imperative that
      is to save a life and that this is preferable to abortion. Those against, believe
      that an inadequate discrimination against women is being exerted on one hand by
      subjecting them to a complex, inefficient and dangerous procedure, and on the
      other, against embryos when many healthy ones are rejected because they are not
      compatible, or because of the dangers to the embryo, and also the psychological
      problems for the sick child as well as the donor. In the bioethical journals, we 
      found a higher proportion of papers that are in its favor than in biomedical
      journals. The arguments are similar to those of the bioethical ones, but there
      are some particular arguments such as that the autonomy of parents must be
      respected; that it is a success of the common sense; that it is not an invasive
      process as it is considered; that it only involves blood donation not a solid
      organ; that the child that donates will feel accompanied by the saved one and
      he/she will feel the satisfaction of since having helped someone to live because 
      without this procedure, the baby child would probably not have been born. The
      arguments against are the discrimination women undergo when they are subjected to
      this procedure with potential risks for her, the embryos and children. IN
      CONCLUSION: a) the morality of <<saviour sibling>> medicine not has been debated 
      in the bioethics and biomedical community before its implementation b) in both
      communities the majority of authors consider it to be ethically licit; c)
      paradoxically there is a greater relative percentage of authors who are critical 
      of it within the biomedical field than in bioethics; d) from a personalist
      bioethics perspective a human embryo is endowed with the dignity of a person and 
      as such must be respected, this technique being an positive eugenics practice, in
      which, after previous selection health embryos are deprived of their right to
      exist.
FAU - Arango Restrepo, Pablo
AU  - Arango Restrepo P
AD  - Departamento de Bioetica, Facultad de Medicina, Universidad de La Sabana, Chia,
      Colombia. pablo.arango@unisabana.edu.co
FAU - Sanchez Abad, Pedro Jose
AU  - Sanchez Abad PJ
FAU - Pastor, Luis Miguel
AU  - Pastor LM
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Diagnostico Genetico Preimplantatorio y el ''Bebe Medicamento'': Criterios Eticos
      Encontrados en la Literatura Biomedica y Bioetica.
PL  - Spain
TA  - Cuad Bioet
JT  - Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y
      Etica Medica
JID - 101312976
SB  - IM
MH  - Abortion, Induced/ethics
MH  - Blastocyst
MH  - Blood Donors
MH  - Child Advocacy/ethics/legislation & jurisprudence
MH  - Embryo Disposition
MH  - Eugenics/legislation & jurisprudence
MH  - Female
MH  - Genetic Diseases, Inborn/genetics/surgery
MH  - Hematopoietic Stem Cell Transplantation/ethics
MH  - Humans
MH  - Infant, Newborn
MH  - Personal Autonomy
MH  - Personhood
MH  - Pregnancy
MH  - Preimplantation Diagnosis/*ethics
MH  - *Siblings
MH  - Value of Life
EDAT- 2012/11/08 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/11/08 06:00
PHST- 2012/03/19 00:00 [received]
PHST- 2012/05/27 00:00 [accepted]
PHST- 2012/11/08 06:00 [entrez]
PHST- 2012/11/08 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
PST - ppublish
SO  - Cuad Bioet. 2012 May-Aug;23(78):301-20.


PMID- 23130744
OWN - NLM
STAT- MEDLINE
DCOM- 20131122
LR  - 20141120
IS  - 1132-1989 (Print)
IS  - 1132-1989 (Linking)
VI  - 23
IP  - 78
DP  - 2012 May-Aug
TI  - [Ethical reflections on cell reprogramming].
PG  - 287-99
AB  - New advances in cell reprogramming, and particularly in obtaining iPS cells, have
      represented a promising possibility for avoiding the use of human embryonic cells
      in experimental research and clinical medicine, use which is ethically
      unacceptable, as obtaining these cells requires the destruction of human embryos.
      The road travelled to arrive at the discovery of iPS cells, and especially the
      ethical assessment of each of the steps taken to that end, are evaluated in this 
      paper. The ethical judgement merited by the various uses that can be made of iPS 
      cells is also examined, because just when it seemed that iPS cells could resolve 
      the ethical problems inherent to the use of embryonic stem cells, new
      possibilities for using iPS cells, especially related with human reproduction,
      have opened up expectations for using these cells that are far removed from the
      most fundamental ethical standards. We conclude that the ethical debate on cell
      reprogramming and particularly on the experimental and clinical use of iPS cells 
      remains open.
FAU - Aznar Lucea, Justo
AU  - Aznar Lucea J
AD  - Instituto de Ciencias de la Vida de la Universidad Catolica de Valencia, Espana. 
      justo.aznar@ucv.es
FAU - Martinez, Miriam
AU  - Martinez M
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Reflexion Etica Alrededor de la Reprogramacion Celular.
PL  - Spain
TA  - Cuad Bioet
JT  - Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y
      Etica Medica
JID - 101312976
SB  - IM
MH  - Adult Stem Cells/cytology
MH  - Aneuploidy
MH  - Animals
MH  - Cell Fusion
MH  - Cell Transdifferentiation
MH  - Cellular Reprogramming/*ethics
MH  - Clinical Trials as Topic
MH  - Embryo Disposition
MH  - Embryonic Stem Cells/cytology
MH  - Female
MH  - Fertilization in Vitro
MH  - Human Rights
MH  - Humans
MH  - *Induced Pluripotent Stem Cells/transplantation
MH  - Male
MH  - Mice
MH  - Pluripotent Stem Cells/cytology
MH  - Regenerative Medicine/*ethics/legislation & jurisprudence/methods
MH  - Research Embryo Creation
MH  - Stem Cell Research/ethics
EDAT- 2012/11/08 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/11/08 06:00
PHST- 2011/10/08 00:00 [received]
PHST- 2011/12/05 00:00 [accepted]
PHST- 2012/11/08 06:00 [entrez]
PHST- 2012/11/08 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
PST - ppublish
SO  - Cuad Bioet. 2012 May-Aug;23(78):287-99.


PMID- 23130743
OWN - NLM
STAT- MEDLINE
DCOM- 20131122
LR  - 20121107
IS  - 1132-1989 (Print)
IS  - 1132-1989 (Linking)
VI  - 23
IP  - 78
DP  - 2012 May-Aug
TI  - Umbilical cord blood banks. Ethical aspects. Public versus private banks.
PG  - 269-85
AB  - The creation of umbilical cord blood (UCB) banks raises interesting medical,
      social, economic and ethical issues. This paper reviews the ethical problems
      specifically. In this respect, it evaluates: a) whether there are advantages to
      the use of UCB compared to bone marrow, b) whether or not it is ethical to create
      UCB banks, c) whether their creation is ethically acceptable in terms of their
      clinical usefulness or d) the use made of them for therapeutic purposes, and
      finally e) whether their creation is ethically justified from a
      cost/profitability point of view. We focus primarily on evaluating the ethical
      controversy between public and private banks, particularly on whether it is
      ethical to bank autologous blood in private UCB banks, on the basis of its
      limited possibilities for use by the cord blood donor. We can conclude that, from
      an ethical point of view, autologous blood banks have limited acceptance among
      specialised researchers, scientific societies and other public institutions.
      Therefore, we believe that it is ethically more acceptable to support the
      creation of public UCB banks for medical and social reasons and, above all, based
      on the principle of justice and human solidarity. Nevertheless, there is no
      definitive ethical argument why a couple, according to their autonomy and
      freedom, cannot bank their child's UCB in a private bank. An equally acceptable
      solution could be the creation of mixed banks, such as that proposed by the
      Virgin Health Bank or like the Spanish system where autologous samples can be
      stored in public banks but with the proviso that if at any time the stored sample
      is required by any person other than the donor, it would have to be given to
      them.
FAU - Aznar Lucea, Justo
AU  - Aznar Lucea J
AD  - Institute of Life Sciences at the Catholic University of Valencia, Espana.
      justo.aznar@ucv.es
LA  - eng
PT  - Journal Article
PL  - Spain
TA  - Cuad Bioet
JT  - Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y
      Etica Medica
JID - 101312976
SB  - IM
MH  - Adult
MH  - Blood Banks/economics/*ethics/legislation & jurisprudence
MH  - Blood Donors
MH  - Blood Preservation
MH  - Bone Marrow Transplantation
MH  - Child
MH  - Cord Blood Stem Cell Transplantation/economics/ethics/legislation & jurisprudence
MH  - Costs and Cost Analysis
MH  - Cryopreservation
MH  - *Fetal Blood
MH  - Genetic Diseases, Inborn/mortality/surgery
MH  - Hematologic Neoplasms/mortality/surgery
MH  - Humans
MH  - Infant, Newborn
MH  - Ownership
MH  - Personal Autonomy
MH  - Private Sector/economics/ethics/legislation & jurisprudence
MH  - Public Sector/economics/ethics/legislation & jurisprudence
MH  - Spain
EDAT- 2012/11/08 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/11/08 06:00
PHST- 2012/02/08 00:00 [received]
PHST- 2012/07/14 00:00 [accepted]
PHST- 2012/11/08 06:00 [entrez]
PHST- 2012/11/08 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
PST - ppublish
SO  - Cuad Bioet. 2012 May-Aug;23(78):269-85.


PMID- 23130564
OWN - NLM
STAT- MEDLINE
DCOM- 20130422
LR  - 20220419
IS  - 1557-9077 (Electronic)
IS  - 1050-7256 (Linking)
VI  - 22
IP  - 11
DP  - 2012 Nov
TI  - American Thyroid Association guidelines for management of patients with
      anaplastic thyroid cancer.
PG  - 1104-39
LID - 10.1089/thy.2012.0302 [doi]
AB  - BACKGROUND: Anaplastic thyroid cancer (ATC) is a rare but highly lethal form of
      thyroid cancer. Rapid evaluation and establishment of treatment goals are
      imperative for optimum patient management and require a multidisciplinary team
      approach. Here we present guidelines for the management of ATC. The development
      of these guidelines was supported by the American Thyroid Association (ATA),
      which requested the authors, members the ATA Taskforce for ATC, to independently 
      develop guidelines for ATC. METHODS: Relevant literature was reviewed, including 
      serial PubMed searches supplemented with additional articles. The quality and
      strength of recommendations were adapted from the Clinical Guidelines Committee
      of the American College of Physicians, which in turn was developed by the Grading
      of Recommendations Assessment, Development and Evaluation workshop. RESULTS: The 
      guidelines include the diagnosis, initial evaluation, establishment of treatment 
      goals, approaches to locoregional disease (surgery, radiotherapy, systemic
      therapy, supportive care during active therapy), approaches to
      advanced/metastatic disease, palliative care options, surveillance and long-term 
      monitoring, and ethical issues including end of life. The guidelines include 65
      recommendations. CONCLUSIONS: These are the first comprehensive guidelines for
      ATC and provide recommendations for management of this extremely aggressive
      malignancy. Patients with stage IVA/IVB resectable disease have the best
      prognosis, particularly if a multimodal approach (surgery, radiation, systemic
      therapy) is used, and some stage IVB unresectable patients may respond to
      aggressive therapy. Patients with stage IVC disease should be considered for a
      clinical trial or hospice/palliative care, depending upon their preference.
FAU - Smallridge, Robert C
AU  - Smallridge RC
AD  - Mayo Clinic, Jacksonville, Florida 32224, USA. smallridge.robert@mayo.edu
FAU - Ain, Kenneth B
AU  - Ain KB
FAU - Asa, Sylvia L
AU  - Asa SL
FAU - Bible, Keith C
AU  - Bible KC
FAU - Brierley, James D
AU  - Brierley JD
FAU - Burman, Kenneth D
AU  - Burman KD
FAU - Kebebew, Electron
AU  - Kebebew E
FAU - Lee, Nancy Y
AU  - Lee NY
FAU - Nikiforov, Yuri E
AU  - Nikiforov YE
FAU - Rosenthal, M Sara
AU  - Rosenthal MS
FAU - Shah, Manisha H
AU  - Shah MH
FAU - Shaha, Ashok R
AU  - Shaha AR
FAU - Tuttle, R Michael
AU  - Tuttle RM
CN  - American Thyroid Association Anaplastic Thyroid Cancer Guidelines Taskforce
LA  - eng
PT  - Journal Article
PT  - Practice Guideline
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Thyroid
JT  - Thyroid : official journal of the American Thyroid Association
JID - 9104317
SB  - IM
MH  - Humans
MH  - Prognosis
MH  - Thyroid Carcinoma, Anaplastic
MH  - Thyroid Gland/pathology
MH  - Thyroid Neoplasms/*diagnosis/pathology/*therapy
EDAT- 2012/11/08 06:00
MHDA- 2013/04/23 06:00
CRDT- 2012/11/08 06:00
PHST- 2012/11/08 06:00 [entrez]
PHST- 2012/11/08 06:00 [pubmed]
PHST- 2013/04/23 06:00 [medline]
AID - 10.1089/thy.2012.0302 [doi]
PST - ppublish
SO  - Thyroid. 2012 Nov;22(11):1104-39. doi: 10.1089/thy.2012.0302.


PMID- 23130388
OWN - NLM
STAT- MEDLINE
DCOM- 20121129
LR  - 20191027
IS  - 1553-7250 (Print)
IS  - 1553-7250 (Linking)
VI  - 38
IP  - 10
DP  - 2012 Oct
TI  - Anatomy of an incident disclosure: the importance of dialogue.
PG  - 435-42
AB  - BACKGROUND: Disclosure of health care incidents to patients and family members,
      as an ethical imperative, is becoming increasingly prevalent. The experiences of 
      a woman whose husband died forms the basis for a case study of how she and her
      family and friends were able to renegotiate clinicians' understandings of what
      had gone wrong and influence their views of what needed to be done in response.
      METHODS: The case was constructed in late 2010 using the replicated single-case
      approach, which involved repeated checking and correcting details of an interview
      with the patient's wife. Her husband, diagnosed with multiple myeloma in 2006,
      was hospitalized in January 2009 following a hip replacement. While in the
      hospital, he received a vasopressin overdose. He died in February 2009. THE
      DISCLOSURE PROCESS: The basis of the disclosure was the drug error, yet the
      patient's wife informed the caller (the head of the ICU), "You've got a greater
      problem than a drug error... you've got a massive, big communication problem
      here." The disclosure process, which unfolded in a series of phone calls and
      meetings, enabled the patient's wife and her family not only to ask questions but
      to put forward their knowledge, views, and concerns, and it moved from
      "disclosing an incident" (the vasopressin overdose) to addressing repeated
      communication failures and inappropriate behaviors. As a result, the disclosure
      process became a genuine dialogue that informed the clinicians as much as the
      family. CONCLUSIONS: This case study expands our understanding of what is
      possible as part of disclosure communication. Patients and family members can and
      should play a critical role in quality improvement and patient safety, given
      their knowledge and questions about the trajectory of care and their passion for 
      ensuring that similar incidents do not recur to harm others.
FAU - Iedema, Rick
AU  - Iedema R
AD  - Centre for Health Communication, University of Technology, Sydney, Australia.
      r.iedema@uts.edu.au
FAU - Allen, Suellen
AU  - Allen S
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Jt Comm J Qual Patient Saf
JT  - Joint Commission journal on quality and patient safety
JID - 101238023
RN  - 0 (Hemostatics)
RN  - 11000-17-2 (Vasopressins)
SB  - IM
MH  - Blood Transfusion
MH  - *Communication
MH  - Confidentiality
MH  - Disclosure/*ethics
MH  - Documentation
MH  - Drug Overdose/complications
MH  - Female
MH  - Hemostatics/poisoning
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Medication Errors/*ethics
MH  - *Physician-Patient Relations
MH  - Quality of Health Care
MH  - Vasopressins/poisoning
EDAT- 2012/11/08 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/11/08 06:00
PHST- 2012/11/08 06:00 [entrez]
PHST- 2012/11/08 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - S1553-7250(12)38057-4 [pii]
AID - 10.1016/s1553-7250(12)38057-4 [doi]
PST - ppublish
SO  - Jt Comm J Qual Patient Saf. 2012 Oct;38(10):435-42. doi:
      10.1016/s1553-7250(12)38057-4.


PMID- 23129816
OWN - NLM
STAT- MEDLINE
DCOM- 20141021
LR  - 20181202
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 40
IP  - 3
DP  - 2014 Mar
TI  - Organ markets and harms: a reply to Dworkin, Radcliffe Richards and Walsh.
PG  - 155-6
LID - 10.1136/medethics-2012-101083 [doi]
FAU - Rippon, Simon
AU  - Rippon S
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20121105
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
CON - J Med Ethics. 2014 Mar;40(3):151-2. PMID: 22718855
CON - J Med Ethics. 2014 Mar;40(3):153-4. PMID: 22751956
CON - J Med Ethics. 2014 Mar;40(3):152-3. PMID: 23087186
MH  - Commerce/*ethics
MH  - *Decision Making
MH  - Humans
MH  - *Living Donors
MH  - Paternalism/*ethics
MH  - *Personal Autonomy
MH  - *Poverty
MH  - *Social Justice
MH  - Tissue and Organ Procurement/*ethics
MH  - *Vulnerable Populations
OTO - NOTNLM
OT  - Donation/Procurement of Organs/Tissues
OT  - Kidneys
OT  - Philosophical Ethics
OT  - Political Philosophy
EDAT- 2012/11/07 06:00
MHDA- 2014/10/22 06:00
CRDT- 2012/11/07 06:00
PHST- 2012/11/07 06:00 [entrez]
PHST- 2012/11/07 06:00 [pubmed]
PHST- 2014/10/22 06:00 [medline]
AID - medethics-2012-101083 [pii]
AID - 10.1136/medethics-2012-101083 [doi]
PST - ppublish
SO  - J Med Ethics. 2014 Mar;40(3):155-6. doi: 10.1136/medethics-2012-101083. Epub 2012
      Nov 5.


PMID- 23129739
OWN - NLM
STAT- MEDLINE
DCOM- 20130221
LR  - 20181202
IS  - 1527-7755 (Electronic)
IS  - 0732-183X (Linking)
VI  - 31
IP  - 1
DP  - 2013 Jan 1
TI  - Toward improved understanding of the ethical and clinical issues surrounding
      mandatory research biopsies.
PG  - 1-2
LID - 10.1200/JCO.2012.44.8589 [doi]
FAU - Peppercorn, Jeffrey
AU  - Peppercorn J
LA  - eng
PT  - Editorial
PT  - Comment
DEP - 20121105
PL  - United States
TA  - J Clin Oncol
JT  - Journal of clinical oncology : official journal of the American Society of
      Clinical Oncology
JID - 8309333
SB  - IM
CON - J Clin Oncol. 2013 Jan 1;31(1):17-22. PMID: 23129736
MH  - Biomedical Research/*standards
MH  - Biopsy/*ethics
MH  - Clinical Trials as Topic/*ethics
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Medical Oncology/*ethics
MH  - Neoplasms/*pathology
EDAT- 2012/11/07 06:00
MHDA- 2013/02/22 06:00
CRDT- 2012/11/07 06:00
PHST- 2012/11/07 06:00 [entrez]
PHST- 2012/11/07 06:00 [pubmed]
PHST- 2013/02/22 06:00 [medline]
AID - JCO.2012.44.8589 [pii]
AID - 10.1200/JCO.2012.44.8589 [doi]
PST - ppublish
SO  - J Clin Oncol. 2013 Jan 1;31(1):1-2. doi: 10.1200/JCO.2012.44.8589. Epub 2012 Nov 
      5.


PMID- 23129572
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121107
LR  - 20220129
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 6
DP  - 2012
TI  - Blood pressure in different ethnic groups (BP-Eth): a mixed methods study.
LID - 10.1136/bmjopen-2012-001598 [doi]
LID - e001598 [pii]
AB  - INTRODUCTION: People of South Asian, African-Caribbean and Irish ethnicity are
      known to have worse cardiovascular outcomes than those from the white British
      group. While the reasons underpinning this are complex, the effect of
      hypertension is both significant and modifiable. In recent years, there has been 
      increasing interest in and uptake of 'out-of-office' methods for blood pressure
      (BP) monitoring. However, guidance in this area has been largely based on
      research among the white population. This study aims to answer the following
      questions: (1) How often and in what ways does blood pressure (BP) monitoring
      occur and how does this differ between white and the above minority ethnic
      populations. (2) Are the thresholds for diagnosis of hypertension, and treatment 
      targets in hypertension comparable for white British and minority ethnic
      populations using different measurement modalities: office blood pressure,
      ambulatory BP monitoring and home monitoring? (3) What preferences for BP
      measurement do people from white and minority ethnic populations have? METHODS
      AND ANALYSIS: A mixed methods approach will be used including the following: (1) 
      A postal survey sent to 8000 hypertensive and not-known-to-be-hypertensive people
      from all four ethnic groups will determine current patterns of BP monitoring. (2)
      A validation study will compare BP measurement by ambulatory monitoring with
      office standard measurement, office research measurement and home monitoring in
      200 people from each of the ethnic groups concerned. (3) Focus groups organised
      by ethnicity and gender will gather qualitative data regarding patient
      preferences for and experiences of BP measurement in each of the given
      modalities. The data collected from these phases will be analysed appropriately
      in order to answer the above research questions. ETHICS AND DISSEMINATION:
      Ethical approval has been gained from the Black Country Research Ethics
      Committee: Ref 09/H1202/114. The results of this work will be disseminated via
      journal publication and conference presentation.
FAU - Wood, Sally
AU  - Wood S
AD  - Primary Care Clinical Sciences, NIHR School for Primary Care Research, University
      of Birmingham, Edgbaston, Birmingham, UK.
FAU - Martin, Una
AU  - Martin U
FAU - Gill, Paramjit
AU  - Gill P
FAU - Greenfield, Sheila M
AU  - Greenfield SM
FAU - Haque, M Sayeed
AU  - Haque MS
FAU - Mant, Jonathan
AU  - Mant J
FAU - Mohammed, Mohammed A
AU  - Mohammed MA
FAU - Heer, Gurdip
AU  - Heer G
FAU - Johal, Amanpreet
AU  - Johal A
FAU - Kaur, Ramandeep
AU  - Kaur R
FAU - Schwartz, Claire
AU  - Schwartz C
FAU - McManus, Richard J
AU  - McManus RJ
LA  - eng
GR  - CDF/01/017/DH_/Department of Health/United Kingdom
GR  - PB-PG-1207-15042/DH_/Department of Health/United Kingdom
PT  - Journal Article
DEP - 20121105
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3532997
EDAT- 2012/11/07 06:00
MHDA- 2012/11/07 06:01
CRDT- 2012/11/07 06:00
PHST- 2012/11/07 06:00 [entrez]
PHST- 2012/11/07 06:00 [pubmed]
PHST- 2012/11/07 06:01 [medline]
AID - bmjopen-2012-001598 [pii]
AID - 10.1136/bmjopen-2012-001598 [doi]
PST - epublish
SO  - BMJ Open. 2012 Nov 5;2(6). pii: bmjopen-2012-001598. doi:
      10.1136/bmjopen-2012-001598. Print 2012.


PMID- 23128901
OWN - NLM
STAT- MEDLINE
DCOM- 20131104
LR  - 20151119
IS  - 1477-030X (Electronic)
IS  - 0269-2163 (Linking)
VI  - 27
IP  - 4
DP  - 2013 Apr
TI  - Off-label prescribing in palliative care - a cross-sectional national survey of
      palliative medicine doctors.
PG  - 320-8
LID - 10.1177/0269216312464263 [doi]
AB  - BACKGROUND: Regulatory bodies including the European Medicines Agency register
      medications (formulation, route of administration) for specific clinical
      indications. Once registered, prescription is at clinicians' discretion.
      Off-label use is beyond the registered use. While off-label prescribing may, at
      times, be appropriate, efficacy and toxicity data are often lacking. AIM: The aim
      of this study was to document off-label use policies (including disclosure and
      consent) in Australian palliative care units and current practices by palliative 
      care clinicians. DESIGN: A national, cross-sectional survey was conducted online 
      following an invitation letter. The survey asked clinicians their most frequent
      off-label medication/indication dyads and unit policies. Dyads were classified
      into unregistered, off-label and on-label, and for the latter, whether
      medications were nationally subsidised. SETTING/PARTICIPANTS: All Australian
      palliative medicine Fellows and advanced trainees. RESULTS: Overall, 105
      clinicians responded (53% response rate). The majority did not have policies on
      off-label medications, and documented consent rarely. In all, 236
      medication/indication dyads for 36 medications were noted: 45 dyads (19%) were
      for two unregistered medications, 118 dyads (50%) were for 26 off-label
      medications and 73 dyads (31%) were for 12 on-label medications. CONCLUSIONS:
      Off-label prescribing with its clinical, legal and ethical implications is common
      yet poorly recognised by clinicians. A distinction needs to be made between where
      quality evidence exists but registration has not been updated by the
      pharmaceutical sponsor and the evidence has not been generated. Further research 
      is required to quantify any iatrogenic harm from off-label prescribing in
      palliative care.
FAU - To, Timothy H M
AU  - To TH
AD  - Discipline, Palliative & Supportive Services, Flinders University, Adelaide,
      Australia. timothy.to@health.sa.gov.au
FAU - Agar, Meera
AU  - Agar M
FAU - Shelby-James, Tania
AU  - Shelby-James T
FAU - Abernethy, Amy P
AU  - Abernethy AP
FAU - Doogue, Matthew
AU  - Doogue M
FAU - Rowett, Debra
AU  - Rowett D
FAU - Ko, Danielle
AU  - Ko D
FAU - Currow, David C
AU  - Currow DC
LA  - eng
PT  - Journal Article
DEP - 20121105
PL  - England
TA  - Palliat Med
JT  - Palliative medicine
JID - 8704926
SB  - IM
MH  - Adult
MH  - Australia
MH  - Cross-Sectional Studies
MH  - Drug and Narcotic Control
MH  - Female
MH  - Humans
MH  - Male
MH  - Off-Label Use/*ethics/standards
MH  - *Palliative Care
MH  - Practice Patterns, Physicians'/ethics/legislation & jurisprudence/*standards
EDAT- 2012/11/07 06:00
MHDA- 2013/11/05 06:00
CRDT- 2012/11/07 06:00
PHST- 2012/11/07 06:00 [entrez]
PHST- 2012/11/07 06:00 [pubmed]
PHST- 2013/11/05 06:00 [medline]
AID - 0269216312464263 [pii]
AID - 10.1177/0269216312464263 [doi]
PST - ppublish
SO  - Palliat Med. 2013 Apr;27(4):320-8. doi: 10.1177/0269216312464263. Epub 2012 Nov
      5.


PMID- 23128586
OWN - NLM
STAT- MEDLINE
DCOM- 20130528
LR  - 20191210
IS  - 1661-7819 (Electronic)
IS  - 1661-7800 (Linking)
VI  - 103
IP  - 1
DP  - 2013
TI  - The European database for subspecialist training in neonatology - transparency
      achieved.
PG  - 74-82
LID - 10.1159/000342932 [doi]
AB  - BACKGROUND: The European Society for Neonatology (ESN) developed a curriculum for
      subspecialist training in Europe recommending standards for national neonatal
      training programmes. We speculate whether these official recommendations are
      widely accepted or used in practice. OBJECTIVES: To characterize the variation in
      national neonatal training programmes, to enhance transparency, and to compare
      them to the ESN Curriculum. METHODS: We constructed a database based on the
      backbone of the ESN Curriculum: (1) training - knowledge, (2) training - skills, 
      (3) key competencies, (4) personal development, and (5) recording of progress.
      National neonatal representatives from all 30 member states of the Union of
      European Medical Specialties (UEMS) provided data on national training
      programmes. RESULTS: Although only one country (3%) based its neonatology
      training entirely on the ESN Curriculum, we found high levels of uniformity among
      the UEMS member countries regarding knowledge, skills, and key competencies
      needed to practice neonatology at a tertiary care level. Discrepancy was
      encountered on ethical and legal issues and on personal development of the
      trainees. Mentoring and professional evaluation was generally not implemented in 
      the participating countries. CONCLUSIONS: There is an awareness and readiness to 
      focus on educational demands for neonatal trainees. Further discussions about the
      overall educational goals of neonatal training and the essence of practicing
      neonatology in each country are needed. The ESN will undertake this process to
      provide an updated and effective syllabus aimed to harmonize care and outcomes
      for babies and their families across Europe.
CI  - Copyright (c) 2012 S. Karger AG, Basel.
FAU - Breindahl, Morten
AU  - Breindahl M
AD  - Department of Neonatology, The National University Hospital Rigshospitalet,
      Copenhagen, Denmark. Breindahl @ dadlnet.dk
FAU - Blennow, Mats
AU  - Blennow M
FAU - Fauchere, Jean-Claude
AU  - Fauchere JC
FAU - Lluch, Marta Thio
AU  - Lluch MT
FAU - De Luca, Daniele
AU  - De Luca D
FAU - Marlow, Neil
AU  - Marlow N
FAU - Picaud, Jean-Charles
AU  - Picaud JC
FAU - Roehr, Charles Christoph
AU  - Roehr CC
FAU - Vanpee, Mireille
AU  - Vanpee M
FAU - Vilamor, Eduardo
AU  - Vilamor E
FAU - Zaharie, Gabriela
AU  - Zaharie G
FAU - Greisen, Gorm
AU  - Greisen G
CN  - European Society for Neonatology (ESN)
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20121031
PL  - Switzerland
TA  - Neonatology
JT  - Neonatology
JID - 101286577
SB  - IM
MH  - Achievement
MH  - Clinical Competence/statistics & numerical data
MH  - Databases, Factual/*standards
MH  - Education, Medical/organization & administration/*standards/statistics &
      numerical data
MH  - Europe/epidemiology
MH  - Guideline Adherence/statistics & numerical data
MH  - Humans
MH  - Infant, Newborn
MH  - Needs Assessment/organization & administration
MH  - Neonatology/*education/organization & administration/*standards/statistics &
      numerical data
MH  - Practice Guidelines as Topic/standards
MH  - Societies, Medical/legislation & jurisprudence
MH  - Specialization/standards/statistics & numerical data
MH  - Truth Disclosure
EDAT- 2012/11/07 06:00
MHDA- 2013/05/29 06:00
CRDT- 2012/11/07 06:00
PHST- 2012/03/02 00:00 [received]
PHST- 2012/08/21 00:00 [accepted]
PHST- 2012/11/07 06:00 [entrez]
PHST- 2012/11/07 06:00 [pubmed]
PHST- 2013/05/29 06:00 [medline]
AID - 000342932 [pii]
AID - 10.1159/000342932 [doi]
PST - ppublish
SO  - Neonatology. 2013;103(1):74-82. doi: 10.1159/000342932. Epub 2012 Oct 31.


PMID- 23127868
OWN - NLM
STAT- MEDLINE
DCOM- 20140114
LR  - 20220316
IS  - 1532-2971 (Electronic)
IS  - 1090-0233 (Linking)
VI  - 195
IP  - 1
DP  - 2013 Jan
TI  - How to improve housing conditions of laboratory animals: the possibilities of
      environmental refinement.
PG  - 24-32
LID - 10.1016/j.tvjl.2012.09.023 [doi]
LID - S1090-0233(12)00421-2 [pii]
AB  - Housing systems for captive animals have often been designed on the basis of
      economic and ergonomic considerations, such as equipment, costs, space, workload,
      ability to observe the animals and to maintain a certain degree of hygiene, with 
      little or no consideration for animal welfare. Environmental refinement can be
      defined as any modification in the environment of captive animals that seeks to
      enhance the physical and psychological well-being of the animals by providing
      stimuli which meet the animals' species-specific needs. This article provides an 
      overview of environmental factors that influence the well-being of captive
      animals with specific reference to the needs of the most common laboratory
      species. It is important to evaluate environmental refinement in terms of the
      benefit to the animal, by assessing the use of and preference for certain
      enrichment, the effect on behaviour, and the performance of species-typical
      behaviour on physiological parameters. It is also necessary to evaluate the
      impact of refinement on scientific outcome, including whether and how statistical
      power is affected. Communication and team work between animal welfare scientists,
      animal research scientists, institutional animal welfare officers, veterinarians 
      and animal ethics committees, animal facility management and personnel, are
      essential for success.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Baumans, V
AU  - Baumans V
AD  - Dept. Animals, Science and Society, Div. Laboratory Animal Science, Utrecht
      University, P.O. Box 80166, 3508 TD Utrecht, The Netherlands. v.baumans@uu.nl
FAU - Van Loo, P L P
AU  - Van Loo PL
LA  - eng
PT  - Journal Article
DEP - 20121103
PL  - England
TA  - Vet J
JT  - Veterinary journal (London, England : 1997)
JID - 9706281
SB  - IM
CIN - Vet J. 2013 Jan;195(1):4-5. PMID: 23261762
MH  - Animal Welfare/*standards
MH  - Animals
MH  - *Animals, Laboratory
MH  - Housing, Animal/*standards
MH  - Species Specificity
EDAT- 2012/11/07 06:00
MHDA- 2014/01/15 06:00
CRDT- 2012/11/07 06:00
PHST- 2011/10/07 00:00 [received]
PHST- 2012/08/16 00:00 [revised]
PHST- 2012/09/26 00:00 [accepted]
PHST- 2012/11/07 06:00 [entrez]
PHST- 2012/11/07 06:00 [pubmed]
PHST- 2014/01/15 06:00 [medline]
AID - S1090-0233(12)00421-2 [pii]
AID - 10.1016/j.tvjl.2012.09.023 [doi]
PST - ppublish
SO  - Vet J. 2013 Jan;195(1):24-32. doi: 10.1016/j.tvjl.2012.09.023. Epub 2012 Nov 3.


PMID- 23127734
OWN - NLM
STAT- MEDLINE
DCOM- 20130116
LR  - 20211021
IS  - 1942-5546 (Electronic)
IS  - 0025-6196 (Linking)
VI  - 87
IP  - 11
DP  - 2012 Nov
TI  - End-of-life care decisions: importance of reviewing systems and limitations after
      2 recent North American cases.
PG  - 1098-105
LID - 10.1016/j.mayocp.2012.04.019 [doi]
LID - S0025-6196(12)00850-6 [pii]
AB  - Two recent and unfortunate North American cases involving end-of-life treatment
      highlight the difficulties surrounding medical futility conflicts. As countries
      have explored the greater influence that patients and their representatives may
      play on end-of-life treatment decisions, the benefits and struggles involved with
      such a movement must be appreciated. These 2 cases are used to examine the
      present systems existing in the United States and Canada for resolving
      end-of-life decisions, including the difficulty in defining medical futility, the
      role of medical ethics committees, and controversies involving surrogate decision
      making.
CI  - Copyright (c) 2012 Mayo Foundation for Medical Education and Research. Published 
      by Elsevier Inc. All rights reserved.
FAU - Burkle, Christopher M
AU  - Burkle CM
AD  - Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA.
      burkle.christopher@mayo.edu
FAU - Benson, Jeffre J
AU  - Benson JJ
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Mayo Clin Proc
JT  - Mayo Clinic proceedings
JID - 0405543
SB  - IM
CIN - Mayo Clin Proc. 2012 Nov;87(11):1040-1. PMID: 23127730
MH  - Aged, 80 and over
MH  - Attitude to Death
MH  - Canada
MH  - Caregivers/*ethics/psychology
MH  - Child, Preschool
MH  - Critical Illness/nursing
MH  - Decision Making
MH  - *Ethics, Medical
MH  - Humans
MH  - Intensive Care Units/ethics
MH  - Male
MH  - Medical Futility/*ethics
MH  - Terminal Care/*ethics
MH  - Third-Party Consent/*ethics
MH  - United States
PMC - PMC3532693
EDAT- 2012/11/07 06:00
MHDA- 2013/01/17 06:00
CRDT- 2012/11/07 06:00
PHST- 2012/01/17 00:00 [received]
PHST- 2012/04/02 00:00 [revised]
PHST- 2012/04/06 00:00 [accepted]
PHST- 2012/11/07 06:00 [entrez]
PHST- 2012/11/07 06:00 [pubmed]
PHST- 2013/01/17 06:00 [medline]
AID - S0025-6196(12)00850-6 [pii]
AID - 10.1016/j.mayocp.2012.04.019 [doi]
PST - ppublish
SO  - Mayo Clin Proc. 2012 Nov;87(11):1098-105. doi: 10.1016/j.mayocp.2012.04.019.


PMID- 23127392
OWN - NLM
STAT- MEDLINE
DCOM- 20140911
LR  - 20131115
IS  - 1934-8150 (Electronic)
IS  - 1551-7411 (Linking)
VI  - 9
IP  - 6
DP  - 2013 Nov-Dec
TI  - The current and future roles of community pharmacists: views and experiences of
      patients with type 2 diabetes.
PG  - 777-89
LID - 10.1016/j.sapharm.2012.10.004 [doi]
LID - S1551-7411(12)00321-X [pii]
AB  - BACKGROUND: The current UK government agenda is for community pharmacists to
      assume greater responsibility for medication management in patients with chronic 
      conditions. This agenda may require a significant change in the way patients
      currently interact with their community pharmacist. OBJECTIVES: To explore the
      experiences and views of patients with type 2 diabetes regarding the current and 
      proposed future role of community pharmacists. METHODS: This study used focus
      groups to collect experiences and views of patients with type 2 diabetes. A
      National Health Service (NHS) ethics committee approved this study. Pharmacists
      identified all patients with type 2 diabetes to whom they provided an information
      sheet and a consent form which included a request to supply basic demographic
      details. Focus group members were purposively sampled to gain a diverse range of 
      opinions. Two researchers independently coded and thematically analyzed the
      transcripts. The researchers discussed the emergent themes to ensure all valid
      themes had been identified. RESULTS: Twenty-five participants attended one of 4
      focus groups. Two broad themes were identified: the place of pharmacy in the
      wider primary care team and pharmacy as a healthcare destination. Participants
      who had been living with diabetes for a long time and those who felt they had
      received a lower level of care from the medical practice were more likely to
      acknowledge contributions of pharmacists in their care for advice on side
      effects, drug interactions and supply than participants with a good relationship 
      with their general practitioner (GP) or practice nurse and whose diabetes was
      well controlled. CONCLUSIONS: Participants with type 2 diabetes identified a role
      for pharmacists in their care linked to their perceived expertise on medicines.
      However, the extent to which they would engage with the pharmacist depended on
      the quality of relationship with their GP or practice nurse.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Twigg, Michael J
AU  - Twigg MJ
AD  - School of Pharmacy, University of East Anglia, Norwich NR4 7TJ, UK. Electronic
      address: m.twigg@uea.ac.uk.
FAU - Poland, Fiona
AU  - Poland F
FAU - Bhattacharya, Debi
AU  - Bhattacharya D
FAU - Desborough, James A
AU  - Desborough JA
FAU - Wright, David J
AU  - Wright DJ
LA  - eng
PT  - Journal Article
DEP - 20121103
PL  - United States
TA  - Res Social Adm Pharm
JT  - Research in social & administrative pharmacy : RSAP
JID - 101231974
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Attitude to Health
MH  - Community Pharmacy Services
MH  - Diabetes Mellitus, Type 2/*drug therapy
MH  - Female
MH  - Focus Groups
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Patient Care Team
MH  - *Pharmacists
MH  - Primary Health Care
MH  - *Professional Role
OTO - NOTNLM
OT  - Community pharmacy
OT  - Experiences
OT  - Patients
OT  - Roles
OT  - Type 2 diabetes
EDAT- 2012/11/07 06:00
MHDA- 2014/09/12 06:00
CRDT- 2012/11/07 06:00
PHST- 2012/03/27 00:00 [received]
PHST- 2012/10/07 00:00 [revised]
PHST- 2012/10/08 00:00 [accepted]
PHST- 2012/11/07 06:00 [entrez]
PHST- 2012/11/07 06:00 [pubmed]
PHST- 2014/09/12 06:00 [medline]
AID - S1551-7411(12)00321-X [pii]
AID - 10.1016/j.sapharm.2012.10.004 [doi]
PST - ppublish
SO  - Res Social Adm Pharm. 2013 Nov-Dec;9(6):777-89. doi:
      10.1016/j.sapharm.2012.10.004. Epub 2012 Nov 3.


PMID- 23127240
OWN - NLM
STAT- MEDLINE
DCOM- 20131119
LR  - 20211021
IS  - 1744-6198 (Electronic)
IS  - 0029-6473 (Linking)
VI  - 47
IP  - 4
DP  - 2012 Oct-Dec
TI  - Quality improvement in nursing: administrative mandate or professional
      responsibility?
PG  - 260-7
LID - 10.1111/j.1744-6198.2012.00283.x [doi]
AB  - For professionals, providing quality service and striving for excellence are
      ethical responsibilities. In many hospitals in the United States, however, there 
      is evidence indicating that current quality improvement (QI) involving nurses is 
      not always driven by their professional accountability and professional values.
      QI has become more an administrative mandate than an ethical standard for nurses.
      In this paper, the tension between QI as nurses' professional ethics and an
      administrative mandate will be described, and the implicit ideal-reality gap of
      QI will be examined. The threat to professional nursing posed by the current
      approach to QI will be examined, and ways to incorporate nursing professional
      values in a practical QI effort will be explored.
CI  - (c) 2012 Wiley Periodicals, Inc.
FAU - Izumi, Shigeko
AU  - Izumi S
AD  - College of Nursing, Washington State University, Spokane, WA 99210-1495, USA.
      seiko.izumi@wsu.edu
LA  - eng
GR  - F32 NR010644/NR/NINR NIH HHS/United States
GR  - F32NR010644/NR/NINR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Nurs Forum
JT  - Nursing forum
JID - 0401006
MH  - *Attitude of Health Personnel
MH  - Ethics, Nursing
MH  - Humans
MH  - Nursing Staff, Hospital/ethics/*standards
MH  - Professional Practice/ethics/*standards
MH  - Quality Improvement/ethics/*organization & administration
MH  - *Social Responsibility
PMC - PMC3491580
MID - NIHMS399796
EDAT- 2012/11/07 06:00
MHDA- 2013/11/20 06:00
CRDT- 2012/11/07 06:00
PHST- 2012/11/07 06:00 [entrez]
PHST- 2012/11/07 06:00 [pubmed]
PHST- 2013/11/20 06:00 [medline]
AID - 10.1111/j.1744-6198.2012.00283.x [doi]
PST - ppublish
SO  - Nurs Forum. 2012 Oct-Dec;47(4):260-7. doi: 10.1111/j.1744-6198.2012.00283.x.


PMID- 23127237
OWN - NLM
STAT- MEDLINE
DCOM- 20131119
LR  - 20121106
IS  - 1744-6198 (Electronic)
IS  - 0029-6473 (Linking)
VI  - 47
IP  - 4
DP  - 2012 Oct-Dec
TI  - International nursing exchange and collaboration with China: a perspective from
      the South and the East.
PG  - 236-44
LID - 10.1111/j.1744-6198.2012.00280.x [doi]
AB  - BACKGROUND: There are an imbalanced world power relationships and international
      knowledge system, as well as cultural differences across nations. RESULTS: Based 
      on the author's international experiences, this article describes the needs and
      motivations of international exchange and collaboration in nursing from the
      perspective of both China and Western countries, examines the ethical and
      cultural issues involved, and suggests winning strategies. CONCLUSIONS: Western
      educators and scholars must keep these issues and strategies in mind in order to 
      build a productive, mutually beneficial, and sustainable international exchanges 
      and collaboration.
CI  - (c) 2012 Wiley Periodicals, Inc.
FAU - Xu, Yu
AU  - Xu Y
AD  - School of Nursing, University of Nevada Las Vegas, Las Vegas, NV 89154-3018, USA.
      yu.xu@unlv.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Nurs Forum
JT  - Nursing forum
JID - 0401006
MH  - China
MH  - *Cooperative Behavior
MH  - Culture
MH  - Humans
MH  - *International Educational Exchange
MH  - *Internationality
MH  - Transcultural Nursing/*education/*ethics
MH  - Western World
EDAT- 2012/11/07 06:00
MHDA- 2013/11/20 06:00
CRDT- 2012/11/07 06:00
PHST- 2012/11/07 06:00 [entrez]
PHST- 2012/11/07 06:00 [pubmed]
PHST- 2013/11/20 06:00 [medline]
AID - 10.1111/j.1744-6198.2012.00280.x [doi]
PST - ppublish
SO  - Nurs Forum. 2012 Oct-Dec;47(4):236-44. doi: 10.1111/j.1744-6198.2012.00280.x.


PMID- 23127085
OWN - NLM
STAT- MEDLINE
DCOM- 20130114
LR  - 20220310
IS  - 0094-2405 (Print)
IS  - 0094-2405 (Linking)
VI  - 39
IP  - 11
DP  - 2012 Nov
TI  - Audiovisual biofeedback improves diaphragm motion reproducibility in MRI.
PG  - 6921-8
LID - 10.1118/1.4761866 [doi]
AB  - PURPOSE: In lung radiotherapy, variations in cycle-to-cycle breathing results in 
      four-dimensional computed tomography imaging artifacts, leading to inaccurate
      beam coverage and tumor targeting. In previous studies, the effect of audiovisual
      (AV) biofeedback on the external respiratory signal reproducibility has been
      investigated but the internal anatomy motion has not been fully studied. The aim 
      of this study is to test the hypothesis that AV biofeedback improves diaphragm
      motion reproducibility of internal anatomy using magnetic resonance imaging
      (MRI). METHODS: To test the hypothesis 15 healthy human subjects were enrolled in
      an ethics-approved AV biofeedback study consisting of two imaging sessions spaced
      approximately 1 week apart. Within each session MR images were acquired under
      free breathing and AV biofeedback conditions. The respiratory signal to the AV
      biofeedback system utilized optical monitoring of an external marker placed on
      the abdomen. Synchronously, serial thoracic 2D MR images were obtained to measure
      the diaphragm motion using a fast gradient-recalled-echo MR pulse sequence in
      both coronal and sagittal planes. The improvement in the diaphragm motion
      reproducibility using the AV biofeedback system was quantified by comparing
      cycle-to-cycle variability in displacement, respiratory period, and baseline
      drift. Additionally, the variation in improvement between the two sessions was
      also quantified. RESULTS: The average root mean square error (RMSE) of diaphragm 
      cycle-to-cycle displacement was reduced from 2.6 mm with free breathing to 1.6 mm
      (38% reduction) with the implementation of AV biofeedback (p-value < 0.0001). The
      average RMSE of the respiratory period was reduced from 1.7 s with free breathing
      to 0.3 s (82% reduction) with AV biofeedback (p-value < 0.0001). Additionally,
      the average baseline drift obtained using a linear fit was reduced from 1.6 mmmin
      with free breathing to 0.9 mmmin (44% reduction) with AV biofeedback (p-value =
      0.012). The diaphragm motion reproducibility improvements with AV biofeedback
      were consistent with the abdominal motion reproducibility that was observed from 
      the external marker motion variation. CONCLUSIONS: This study was the first to
      investigate the potential of AV biofeedback to improve the motion reproducibility
      of internal anatomy using MRI. The study demonstrated the significant improvement
      in diaphragm motion reproducibility using AV biofeedback combined with MRI. This 
      system can potentially provide clinically beneficial motion management of
      internal anatomy in MRI and radiotherapy.
FAU - Kim, Taeho
AU  - Kim T
AD  - Radiation Physics Laboratory, Sydney Medical School, University of Sydney,
      Sydney, Australia.
FAU - Pollock, Sean
AU  - Pollock S
FAU - Lee, Danny
AU  - Lee D
FAU - O'Brien, Ricky
AU  - O'Brien R
FAU - Keall, Paul
AU  - Keall P
LA  - eng
GR  - R01 CA093626/CA/NCI NIH HHS/United States
GR  - R01CA93626/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Med Phys
JT  - Medical physics
JID - 0425746
SB  - IM
MH  - Abdomen/physiology
MH  - *Biofeedback, Psychology
MH  - Diaphragm/*physiology
MH  - *Hearing
MH  - Humans
MH  - Lung Neoplasms/diagnosis/physiopathology
MH  - Magnetic Resonance Imaging/*methods
MH  - *Movement
MH  - Reproducibility of Results
MH  - *Vision, Ocular
PMC - PMC3494729
EDAT- 2012/11/07 06:00
MHDA- 2013/01/15 06:00
CRDT- 2012/11/07 06:00
PHST- 2012/11/07 06:00 [entrez]
PHST- 2012/11/07 06:00 [pubmed]
PHST- 2013/01/15 06:00 [medline]
AID - 10.1118/1.4761866 [doi]
PST - ppublish
SO  - Med Phys. 2012 Nov;39(11):6921-8. doi: 10.1118/1.4761866.


PMID- 23125959
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121106
LR  - 20220409
IS  - 2229-5488 (Electronic)
IS  - 2229-3485 (Linking)
VI  - 3
IP  - 3
DP  - 2012 Jul
TI  - Knowledge, attitude and perception/practices (KAP) of medical practitioners in
      India towards adverse drug reaction (ADR) reporting.
PG  - 90-4
LID - 10.4103/2229-3485.100651 [doi]
AB  - OBJECTIVE: The objective was to assess knowledge, attitude and
      perceptions/practices (KAP) of medical practitioners (MPs) in India towards
      Adverse Drug Reaction (ADR) reporting. MATERIALS AND METHODS: A questionnaire was
      designed for assessment of KAP of medical practitioners in India toward ADR
      reporting. This questionnaire was administered to 2-3 medical practitioners from 
      each zone prior to administering final questionnaire which was approved by Disha 
      Independent Ethics Committee, Mumbai. 1200 medical practitioners (about 300 from 
      each zone) from India were selected randomly. RESULTS: 1000 medical practitioners
      out of 1200 (90%), selected at random were approached. A total of 870 provided
      responses to the questionnaire, giving a response rate of 73% of 1200 selected
      randomly. A total of 47.5% respondents reported that they were aware of
      Government ADR centers. A total of 59.2% reported that they are familiar with the
      procedure of reporting ADRs to Government centers. However, only 18.5% of MPs
      have reported the observed ADRs to Government ADR centers. As against this
      relatively large number of MPs (87.9%) have reported ADRs observed during their
      routine practice to medical representatives of pharmaceutical company and NGOs
      (non-Govt. Organizations). A total of 80.5% of respondents agreed that safety
      plays an important role and 96% reported that ADR centers are useful. However,
      only 55.6% of respondents have reported that there is a need for ADR centers.
      CONCLUSION: The study reveals that practitioners are aware of ADR reporting;
      their perception toward ADR reporting is right but it is not reflected when it
      comes to the act of reporting of ADRs. In our sample of 870 respondents only 18.5
      % reported ADRs to some organizations. Only 5% of respondents recorded the
      details of ADR and reported to the manufacturer and 1% of respondents to
      government health ministry. Thus, medical practitioners in India appear to have a
      good knowledge about ADR reporting, the right perception toward ADR reporting.
      However, as far as practice of ADR reporting is concerned it is discouraging.
FAU - Kharkar, Mala
AU  - Kharkar M
AD  - Vice Principal, Patkar and Varde College, B2-12, Mahindra Gardens, S.V.Road,
      Goregaon(west) Mumbai, India.
FAU - Bowalekar, Suresh
AU  - Bowalekar S
LA  - eng
PT  - Journal Article
PL  - India
TA  - Perspect Clin Res
JT  - Perspectives in clinical research
JID - 101551517
PMC - PMC3487231
OTO - NOTNLM
OT  - ADR reporting
OT  - Adverse drug reactions
OT  - pharmacovigilance
EDAT- 2012/11/06 06:00
MHDA- 2012/11/06 06:01
CRDT- 2012/11/06 06:00
PHST- 2012/11/06 06:00 [entrez]
PHST- 2012/11/06 06:00 [pubmed]
PHST- 2012/11/06 06:01 [medline]
AID - 10.4103/2229-3485.100651 [doi]
AID - PCR-3-90 [pii]
PST - ppublish
SO  - Perspect Clin Res. 2012 Jul;3(3):90-4. doi: 10.4103/2229-3485.100651.


PMID- 23125943
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121106
LR  - 20220408
IS  - 2042-0056 (Electronic)
VI  - 2012
DP  - 2012
TI  - Determining the Feasibility of Ambulance-Based Randomised Controlled Trials in
      Patients with Ultra-Acute Stroke: Study Protocol for the "Rapid Intervention with
      GTN in Hypertensive Stroke Trial" (RIGHT, ISRCTN66434824).
PG  - 385753
LID - 10.1155/2012/385753 [doi]
AB  - Background. Time from acute stroke to enrolment in clinical trials needs to be
      reduced to improve the chances of finding effective treatments. No completed
      randomised controlled trials of ambulance-based treatment for acute stroke have
      been reported in the UK, and the practicalities of recruiting, consenting, and
      treating patients are unknown. Methods. RIGHT is an ambulance based,
      single-blind, randomised controlled trial with blinded-outcome assessment. The
      trial will assess feasibility of using ambulance services to deliver ultra-acute 
      stroke treatments; a secondary aim is to assess the effect of glyceryl trinitrate
      (GTN) on haemodynamic variables and functional outcomes. Initial consent,
      randomisation, and treatment are performed by paramedics prior to
      hospitalisation. Patients with ultra-acute stroke (</=4 hours of onset) are
      randomised to transdermal GTN (5 mg/24 hours) or gauze dressing daily for 7 days.
      The primary outcome is systolic blood pressure at 2 hours. Secondary outcomes
      include feasibility, haemodynamics, dependency, and other functional outcomes. A 
      nested qualitative study is included. Trial Status. The trial has all relevant
      ethics and regulatory approvals and recruitment started on February 15, 2010. The
      trial stopped recruitment in December 2011 after 41 patients were recruited.
      Trial Registration. The trial registration number is ISRCTN66434824 and EudraCT
      number is 2007-004766-40.
FAU - Ankolekar, Sandeep
AU  - Ankolekar S
AD  - Stroke Trials Unit, Division of Stroke, University of Nottingham, City Hospital
      Campus, Hucknall Road, Nottingham NG5 1PB, UK.
FAU - Sare, Gillian
AU  - Sare G
FAU - Geeganage, Chamila
AU  - Geeganage C
FAU - Fuller, Michael
AU  - Fuller M
FAU - Stokes, Lynn
AU  - Stokes L
FAU - Sprigg, Nikola
AU  - Sprigg N
FAU - Parry, Ruth
AU  - Parry R
FAU - Siriwardena, A Niroshan
AU  - Siriwardena AN
FAU - Bath, Philip M W
AU  - Bath PM
LA  - eng
GR  - G0501797/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
DEP - 20121016
PL  - United States
TA  - Stroke Res Treat
JT  - Stroke research and treatment
JID - 101529024
PMC - PMC3480012
EDAT- 2012/11/06 06:00
MHDA- 2012/11/06 06:01
CRDT- 2012/11/06 06:00
PHST- 2012/07/08 00:00 [received]
PHST- 2012/09/14 00:00 [revised]
PHST- 2012/09/21 00:00 [accepted]
PHST- 2012/11/06 06:00 [entrez]
PHST- 2012/11/06 06:00 [pubmed]
PHST- 2012/11/06 06:01 [medline]
AID - 10.1155/2012/385753 [doi]
PST - ppublish
SO  - Stroke Res Treat. 2012;2012:385753. doi: 10.1155/2012/385753. Epub 2012 Oct 16.


PMID- 23125398
OWN - NLM
STAT- MEDLINE
DCOM- 20160422
LR  - 20181202
IS  - 1938-2715 (Electronic)
IS  - 1049-9091 (Linking)
VI  - 30
IP  - 7
DP  - 2013 Nov
TI  - Physician attitudes toward advanced directives: a literature review of variables 
      impacting on physicians attitude toward advance directives.
PG  - 696-706
LID - 10.1177/1049909112464544 [doi]
AB  - PURPOSE: To review physician's attitudes as well as the variables that may impact
      on physicians' attitude toward advance directives (ADs). METHOD: Literature
      review of 17 published articles, covering the period 1989 to 2011. FINDINGS:
      Physicians overall have a positive attitude toward patients' AD. However, other
      factors affect this "general positive attitude." These factors influence the
      attitude-behavior relationship of physicians, and hence their actual practice in 
      relation to patients' AD. CONCLUSION: The findings from this review are of
      importance in explaining the differences in the attitude of physicians toward AD 
      and their compliance. This raises the issue of consideration of other ethical
      paradigms/theories in the clinical context other than the framework of
      "principlism-"based autonomy, on which AD leans on. This is important in light of
      the pluralism of ethical theories.
FAU - Coleman, Albert M E
AU  - Coleman AM
AD  - 1Southern Health NHS Foundation Trust, Winchester, UK.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121102
PL  - United States
TA  - Am J Hosp Palliat Care
JT  - The American journal of hospice & palliative care
JID - 9008229
SB  - IM
MH  - *Advance Directives
MH  - Attitude
MH  - Attitude of Health Personnel
MH  - Humans
MH  - *Physicians
OTO - NOTNLM
OT  - advance directive
OT  - attitude
OT  - living will
OT  - perceptions
OT  - physicians
OT  - practice
EDAT- 2012/11/06 06:00
MHDA- 2016/04/23 06:00
CRDT- 2012/11/06 06:00
PHST- 2012/11/06 06:00 [entrez]
PHST- 2012/11/06 06:00 [pubmed]
PHST- 2016/04/23 06:00 [medline]
AID - 1049909112464544 [pii]
AID - 10.1177/1049909112464544 [doi]
PST - ppublish
SO  - Am J Hosp Palliat Care. 2013 Nov;30(7):696-706. doi: 10.1177/1049909112464544.
      Epub 2012 Nov 2.


PMID- 23125264
OWN - NLM
STAT- MEDLINE
DCOM- 20121228
LR  - 20181202
IS  - 2042-7670 (Electronic)
IS  - 0042-4900 (Linking)
VI  - 171
IP  - 18
DP  - 2012 Nov 3
TI  - Ethical decision-making in veterinary practice: using the head and the heart.
PG  - 443-4
LID - 10.1136/vr.e7344 [doi]
FAU - Mullan, Siobhan M
AU  - Mullan SM
LA  - eng
PT  - Editorial
PT  - Comment
PL  - England
TA  - Vet Rec
JT  - The Veterinary record
JID - 0031164
SB  - IM
CON - Vet Rec. 2012 Nov 3;171(18):446. PMID: 23015727
MH  - *Decision Making
MH  - Ethics, Medical/*education
MH  - Female
MH  - Humans
MH  - Male
MH  - Students/*psychology
MH  - Veterinary Medicine/*ethics
EDAT- 2012/11/06 06:00
MHDA- 2012/12/29 06:00
CRDT- 2012/11/06 06:00
PHST- 2012/11/06 06:00 [entrez]
PHST- 2012/11/06 06:00 [pubmed]
PHST- 2012/12/29 06:00 [medline]
AID - vr.e7344 [pii]
AID - 10.1136/vr.e7344 [doi]
PST - ppublish
SO  - Vet Rec. 2012 Nov 3;171(18):443-4. doi: 10.1136/vr.e7344.


PMID- 23124752
OWN - NLM
STAT- MEDLINE
DCOM- 20130326
LR  - 20211021
IS  - 1976-3794 (Electronic)
IS  - 1225-8873 (Linking)
VI  - 50
IP  - 5
DP  - 2012 Oct
TI  - Possible translocation of periodontal pathogens into the lymph nodes draining the
      oral cavity.
PG  - 827-36
LID - 10.1007/s12275-012-2030-8 [doi]
AB  - Numerous publications have reported the presence of periodontopathogenic bacteria
      in peripheral and central vascular lesions. However, it is unclear how this
      bacterial translocation occurs. The objective of this study was to investigate
      whether periodontopathic bacteria are translocated to lymph nodes proximal to the
      oral cavity. Obtaining lymph node samples is not ethically feasible unless they
      are excised as part of the surgical management of patients with cancer. This
      study analyzed formalin-fixed and paraffin-embedded lymph nodes, histologically
      negative for cancer cell invasion, that were excised from 66 patients with
      histories of head and neck cancer. Real-time PCR was performed to amplify the 16S
      ribosomal DNA fragments from Porphyromonas gingivalis, Treponema denticola,
      Aggregatibacter actinomycetemcomitans, Tannerella forsythia, and Prevotella
      intermedia. The relationship between bacterial detection and cancer severity,
      gender, and the use of anti-cancer therapy was examined by Fisher's exact test.
      P. gingivalis, T. forsythia, and P. intermedia were present in 17%, 8%, and 8% of
      the samples of submandibular and submental lymph nodes, respectively. There were 
      no significant relationships between bacterial detection and the cancer disease
      status, patient gender or use of anticancer therapy. According to these data, it 
      appears that the translocation of periodontopathic bacteria may occur via
      lymphatic drainage, irrespective of the cancer disease status, gender or
      anticancer therapy.
FAU - Amodini Rajakaruna, G
AU  - Amodini Rajakaruna G
AD  - Department of Periodontology, Graduate School of Medical and Dental Sciences,
      1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
FAU - Umeda, Makoto
AU  - Umeda M
FAU - Uchida, Keisuke
AU  - Uchida K
FAU - Furukawa, Asuka
AU  - Furukawa A
FAU - Yuan, Bae
AU  - Yuan B
FAU - Suzuki, Yoshimi
AU  - Suzuki Y
FAU - Noriko, Ebe
AU  - Noriko E
FAU - Izumi, Yuichi
AU  - Izumi Y
FAU - Eishi, Yoshinobu
AU  - Eishi Y
LA  - eng
PT  - Journal Article
DEP - 20121104
PL  - Korea (South)
TA  - J Microbiol
JT  - Journal of microbiology (Seoul, Korea)
JID - 9703165
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aggregatibacter actinomycetemcomitans
MH  - Bacteria/genetics/*isolation & purification
MH  - Bacterial Physiological Phenomena
MH  - *Bacterial Translocation
MH  - Female
MH  - Humans
MH  - Lymph Nodes/*microbiology
MH  - Male
MH  - Middle Aged
MH  - Mouth/*microbiology
MH  - Neoplasms/microbiology
MH  - Periodontal Diseases/*microbiology
EDAT- 2012/11/06 06:00
MHDA- 2013/03/27 06:00
CRDT- 2012/11/06 06:00
PHST- 2012/01/25 00:00 [received]
PHST- 2012/06/19 00:00 [accepted]
PHST- 2012/11/06 06:00 [entrez]
PHST- 2012/11/06 06:00 [pubmed]
PHST- 2013/03/27 06:00 [medline]
AID - 10.1007/s12275-012-2030-8 [doi]
PST - ppublish
SO  - J Microbiol. 2012 Oct;50(5):827-36. doi: 10.1007/s12275-012-2030-8. Epub 2012 Nov
      4.


PMID- 23124617
OWN - NLM
STAT- MEDLINE
DCOM- 20131210
LR  - 20130117
IS  - 1552-6801 (Electronic)
IS  - 1077-5587 (Linking)
VI  - 70
IP  - 1 Suppl
DP  - 2013 Feb
TI  - Supporting shared decision making when clinical evidence is low.
PG  - 129S-140S
LID - 10.1177/1077558712460280 [doi]
AB  - Shared decision making (SDM) is the process of providing the patient with
      critical information that can support his or her informed participation in
      decision making. Shared decision making has become accepted as an important
      component of quality health care. Influenced by its foundations in law and ethics
      and by empirical work on its value as a tool to reduce variability in care, a
      perception has developed that SDM is relevant primarily to clinical situations
      with high-quality clinical evidence. This raises the question of the role of SDM 
      in situations when clinical evidence is lacking or of low quality. This article
      posits that SDM is equally relevant and important to low-evidence situations in
      four ways--SDM fosters shared acceptance of uncertainty, closes the gap in
      knowledge between patient and physician, promotes patient empowerment, and
      enhances trust through transparent communication.
FAU - Braddock, Clarence H 3rd
AU  - Braddock CH 3rd
AD  - Stanford University, Stanford, CA 94305, USA. cbrad@stanford.edu
LA  - eng
PT  - Journal Article
DEP - 20121101
PL  - United States
TA  - Med Care Res Rev
JT  - Medical care research and review : MCRR
JID - 9506850
SB  - IM
MH  - Communication
MH  - *Decision Making
MH  - Evidence-Based Medicine/methods/standards
MH  - Humans
MH  - Physician-Patient Relations
MH  - Trust
MH  - Uncertainty
EDAT- 2012/11/06 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/11/06 06:00
PHST- 2012/11/06 06:00 [entrez]
PHST- 2012/11/06 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 1077558712460280 [pii]
AID - 10.1177/1077558712460280 [doi]
PST - ppublish
SO  - Med Care Res Rev. 2013 Feb;70(1 Suppl):129S-140S. doi: 10.1177/1077558712460280. 
      Epub 2012 Nov 1.


PMID- 23124614
OWN - NLM
STAT- MEDLINE
DCOM- 20131210
LR  - 20130117
IS  - 1552-6801 (Electronic)
IS  - 1077-5587 (Linking)
VI  - 70
IP  - 1 Suppl
DP  - 2013 Feb
TI  - The professional medical ethics model of decision making under conditions of
      clinical uncertainty.
PG  - 141S-158S
LID - 10.1177/1077558712461952 [doi]
AB  - The professional medical ethics model of decision making may be applied to
      decisions clinicians and patients make under the conditions of clinical
      uncertainty that exist when evidence is low or very low. This model uses the
      ethical concepts of medicine as a profession, the professional virtues of
      integrity and candor and the patient's virtue of prudence, the moral management
      of medical uncertainty, and trial of intervention. These features combine to
      justifiably constrain clinicians' and patients' autonomy with the goal of
      preventing nondeliberative decisions of patients and clinicians. To prevent
      biased recommendations by the clinician that promote such nondeliberative
      decisions, medically reasonable alternatives supported by low or very low
      evidence should be offered but not recommended. The professional medical ethics
      model of decision making aims to improve the quality of decisions by reducing the
      unacceptable variation that can result from nondeliberative decision making by
      patients and clinicians when evidence is low or very low.
FAU - McCullough, Laurence B
AU  - McCullough LB
AD  - Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston,
      TX 77030-3411, USA. laurence.mccullough@bcm.edu
LA  - eng
PT  - Journal Article
DEP - 20121101
PL  - United States
TA  - Med Care Res Rev
JT  - Medical care research and review : MCRR
JID - 9506850
SB  - IM
MH  - Decision Making/*ethics
MH  - Evidence-Based Medicine/ethics/methods/standards
MH  - Humans
MH  - Models, Theoretical
MH  - Physician's Role
MH  - Physician-Patient Relations/*ethics
MH  - Physicians/ethics
MH  - Practice Guidelines as Topic
MH  - Risk Assessment
MH  - Uncertainty
EDAT- 2012/11/06 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/11/06 06:00
PHST- 2012/11/06 06:00 [entrez]
PHST- 2012/11/06 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 1077558712461952 [pii]
AID - 10.1177/1077558712461952 [doi]
PST - ppublish
SO  - Med Care Res Rev. 2013 Feb;70(1 Suppl):141S-158S. doi: 10.1177/1077558712461952. 
      Epub 2012 Nov 1.


PMID- 23124305
OWN - NLM
STAT- MEDLINE
DCOM- 20131105
LR  - 20191112
IS  - 0040-8891 (Print)
IS  - 0040-8891 (Linking)
VI  - 53
IP  - 3
DP  - 2012
TI  - Establishment and current status of patient community at Tokyo Dental College.
PG  - 147-53
AB  - The "Dental students training to address the needs of each individual patient:
      enhancement of ability to make a comprehensive diagnosis and treatment plans with
      high ethical standards and good communication skills", project launched at Tokyo 
      Dental College was adopted by the Ministry of Education, Culture, Sports, Science
      and Technology as part of its "Program for Promoting University Education and
      Student Support, Theme A: Program for Promoting University Education Reform" in
      2009. One of the main goals of this subject is "the establishment of Patient
      Community". Patient Community members allowed students to gain a more realistic
      experience of clinical practice than simulated patients. The Patient Community
      consists of patients and members of the parents' association who have agreed to
      cooperate for the advancement of dental education, becoming involved in dental
      student education through Communication Studies, which are held for first- to
      fourth-year students. Patient Community members were recruited at the open
      lectures (15 times, between July 10, 2010 and November 30, 2011). The Patient
      Community comprised 24 members, including 8 men and 16 women by November 30,
      2011. The cumulative number of attendees in Communication Studies (I-IV, 6 times)
      was 35, including 13 men and 22 women. Fourteen people applied for admission on
      the day of the open lecture. Seven people signed up between 1 and 7 days after
      the open lecture. On the other hand, only 3 people applied within 8 to 9 days
      after the open lecture. However, interestingly, the ratio of the attendance for
      Communication Studies by Patient Community members who applied 8 to 9 days after 
      the open lecture was higher than that of members who applied for admission on the
      day of the open lecture. Since the number of Patient Community members is
      insufficient for the purposes of the Patient Community, it is necessary to think 
      about how recruitment methods can be made more effective and how such open
      lectures should be conducted in future.
FAU - Yamamoto, Hitoshi
AU  - Yamamoto H
AD  - Dental Education Development Center, Tokyo Dental College, Masago, Mihama-ku,
      Chiba, Japan. hyamamoto@tdc.ac.jp
FAU - Murakami, Satoshi
AU  - Murakami S
FAU - Hirata, Soichiro
AU  - Hirata S
FAU - Sugihara, Naoki
AU  - Sugihara N
FAU - Mochizuki, Riuji
AU  - Mochizuki R
FAU - Takahashi, Toshiyuki
AU  - Takahashi T
FAU - Kawada, Eiji
AU  - Kawada E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Bull Tokyo Dent Coll
JT  - The Bulletin of Tokyo Dental College
JID - 7505414
MH  - Community Participation/statistics & numerical data
MH  - *Education, Dental
MH  - Female
MH  - Humans
MH  - Information Dissemination
MH  - Male
MH  - *Patient Simulation
MH  - *Personnel Selection/statistics & numerical data
MH  - Program Development
MH  - Schools, Dental
MH  - Teaching/methods
MH  - Tokyo
EDAT- 2012/11/06 06:00
MHDA- 2013/11/06 06:00
CRDT- 2012/11/06 06:00
PHST- 2012/11/06 06:00 [entrez]
PHST- 2012/11/06 06:00 [pubmed]
PHST- 2013/11/06 06:00 [medline]
AID - DN/JST.JSTAGE/tdcpublication/53.147 [pii]
AID - 10.2209/tdcpublication.53.147 [doi]
PST - ppublish
SO  - Bull Tokyo Dent Coll. 2012;53(3):147-53. doi: 10.2209/tdcpublication.53.147.


PMID- 23123982
OWN - NLM
STAT- MEDLINE
DCOM- 20121211
LR  - 20151119
IS  - 1357-6321 (Print)
IS  - 1357-6321 (Linking)
VI  - 18
IP  - 8
DP  - 2012 Aug
TI  - Burnout in nurses working in Portuguese palliative care teams: a mixed methods
      study.
PG  - 373-81
AB  - Repeat contact with suffering, dying, and death is considered to be a risk factor
      for burnout among health professionals, particularly nurses working in palliative
      care. A mixed methods study was conducted to identify burnout levels, risk and
      protective factors, prevention strategies, and the emotional impact of working in
      palliative care among nurses in Portugal. A quantitative questionnaire was
      completed by nursing members of nine different palliative care teams and was
      supported by interviews and observation. Although the participants were exposed
      to risk factors, such as work overload, disorganisation, difficult relationships 
      within the team and with patients' relatives, they showed a low risk of burnout. 
      These results appear to be related both to the protective factors
      identified-namely the ethic of care in the relationship the nurses establish with
      patients, families, and within their teams-and to the preventive strategies they 
      actively adopt for burnout prevention. The positive aspects of the nurses' roles 
      help them to build a positive view of their work, which also promotes their own
      personal and professional development.
FAU - Fonseca, Antonio
AU  - Fonseca A
AD  - University of Azores Nursing School of Angra do Herroismo, Catholic University of
      Portugal Bioethics Research Center, Institute of Bioethics Canada dos
      Melancolicos, Angra do Heroismo, Portugal.
FAU - Pereira, Sandra
AU  - Pereira S
FAU - Carvalho, Ana Sofia
AU  - Carvalho AS
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Palliat Nurs
JT  - International journal of palliative nursing
JID - 9506762
MH  - Adaptation, Psychological
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Burnout, Professional/classification/*epidemiology/*psychology
MH  - Female
MH  - Humans
MH  - Male
MH  - Nursing Staff, Hospital/*psychology/*statistics & numerical data
MH  - Palliative Care/*psychology/*statistics & numerical data
MH  - Population Surveillance
MH  - Portugal/epidemiology
MH  - Risk Factors
MH  - Surveys and Questionnaires
EDAT- 2012/11/06 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/11/06 06:00
PHST- 2012/11/06 06:00 [entrez]
PHST- 2012/11/06 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - 10.12968/ijpn.2012.18.8.373 [doi]
PST - ppublish
SO  - Int J Palliat Nurs. 2012 Aug;18(8):373-81. doi: 10.12968/ijpn.2012.18.8.373.


PMID- 23123896
OWN - NLM
STAT- MEDLINE
DCOM- 20121212
LR  - 20181202
IS  - 0966-0461 (Print)
IS  - 0966-0461 (Linking)
VI  - 21
IP  - 19
DP  - 2012 Oct 25-Nov 7
TI  - Assistant practitioners: lessons learned from licensed practical nurses.
PG  - 1160-2, 1164-7
AB  - The role of the assistant practitioner (AP) needs to be defined so they have
      clear career pathways and opportunities for professional development. The author 
      sought to learn from other countries where a sustained effort had been made to
      support practitioners fulfilling this intermediate role. The equivalent of an AP 
      in Canada is the licensed practical nurse (LPN); LPNs are subject to clear
      regulation and practice within their remit of their license. The author travelled
      to Alberta, Canada, and performed a qualitative study to investigate the role of 
      the LPN. LPNs undertake a 2-year diploma-level course and have the opportunity to
      enhance their careers through specialist courses or to train as a RN. LPNs
      benefit from careful regulation, enabling them to have a clear scope of practice,
      a career structure with opportunities for development and consistent ethical
      standards. Lessons can be learned from the LPN model and put in practice in the
      UK; APs need a consistent education programme, a career pathway that promotes
      development and effective regulation.
FAU - Whittingham, Katrina
AU  - Whittingham K
AD  - Department of Nursing and Midwifery, Robert Gordon University, Aberdeen.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Nurs
JT  - British journal of nursing (Mark Allen Publishing)
JID - 9212059
MH  - Alberta
MH  - Education, Nursing/organization & administration
MH  - Ethics
MH  - Humans
MH  - Nurse's Role
MH  - Nurses/*psychology
MH  - *Nursing, Practical
MH  - United Kingdom
MH  - Workforce
EDAT- 2012/11/06 06:00
MHDA- 2012/12/13 06:00
CRDT- 2012/11/06 06:00
PHST- 2012/11/06 06:00 [entrez]
PHST- 2012/11/06 06:00 [pubmed]
PHST- 2012/12/13 06:00 [medline]
AID - 10.12968/bjon.2012.21.19.1160 [doi]
PST - ppublish
SO  - Br J Nurs. 2012 Oct 25-Nov 7;21(19):1160-2, 1164-7. doi:
      10.12968/bjon.2012.21.19.1160.


PMID- 23123749
OWN - NLM
STAT- MEDLINE
DCOM- 20121228
LR  - 20161125
IS  - 0966-0461 (Print)
IS  - 0966-0461 (Linking)
VI  - 21
IP  - 17
DP  - 2012 Sep 27-Oct 10
TI  - Exploring advanced nursing practice: past, present and future.
PG  - 1026-30
AB  - This article examines the nature of advanced nursing practice. It identifies
      confusion around the terms of advanced nurse practitioners (ANPs), nurse
      practitioners and specialist nurses, and identifies what advanced practice is.
      The history of how ANPs evolved is discussed from its haphazard development to a 
      more organised approach. Current advanced practice is identified, along with NHS 
      plans for nurse development. Law, ethics and professional accountability are
      examined in relation to the additional responsibility ANPs have. Finally, the
      author's role as an ANP is considered within the context of primary care and NHS 
      reforms.
FAU - Duke, Natasha
AU  - Duke N
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - England
TA  - Br J Nurs
JT  - British journal of nursing (Mark Allen Publishing)
JID - 9212059
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Nurse Practitioners/*history
MH  - State Medicine
MH  - United Kingdom
EDAT- 2012/11/06 06:00
MHDA- 2012/12/29 06:00
CRDT- 2012/11/06 06:00
PHST- 2012/11/06 06:00 [entrez]
PHST- 2012/11/06 06:00 [pubmed]
PHST- 2012/12/29 06:00 [medline]
AID - 10.12968/bjon.2012.21.17.1026 [doi]
PST - ppublish
SO  - Br J Nurs. 2012 Sep 27-Oct 10;21(17):1026-30. doi: 10.12968/bjon.2012.21.17.1026.


PMID- 23123746
OWN - NLM
STAT- MEDLINE
DCOM- 20121228
LR  - 20220318
IS  - 0966-0461 (Print)
IS  - 0966-0461 (Linking)
VI  - 21
IP  - 17
DP  - 2012 Sep 27-Oct 10
TI  - Hand hygiene compliance: is there a theory-practice-ethics gap?
PG  - 1011-4
AB  - Practice is usually based on tradition, rituals and outdated information; there
      is often an additional gap between theoretical knowledge and its application in
      practice. This theory-practice gap has long existed (Allmark, 1995; Hewison et
      al, 1996). It often arises when theory is ignored because it is seen as
      idealistic and impractical, even if it is practical and beneficial. Most research
      relating to the lack of integration between theory and practice has concluded
      that environmental factors are responsible and will affect learning and practice 
      outcomes. The author believes an additional dimension of ethics is required to
      bridge the gap between theory and practice. This would be a moral obligation to
      ensure theory and practice are integrated. To implement new practices
      effectively, healthcare practitioners must deem these practices worthwhile and
      relevant to their role. This introduces a new concept that the author calls the
      theory-practice-ethics gap. This theory-practice-ethics gap must be considered
      when examining some of the unacceptable outcomes in healthcare practice (Mortell,
      2009). The literature suggests that there is a crisis of ethics where theory and 
      practice integrate, and practitioners are failing to fulfil their duty as
      providers of healthcare and as patient advocates. This article examines the
      theory-practice-ethics gap when applied to hand hygiene. Non-compliance exists in
      hand hygiene among practitioners, which may increase patient mortality and
      morbidity rates, and raise healthcare costs. Infection prevention and control
      programmes to improve hand hygiene among staff include: ongoing education and
      training; easy access to facilities such as wash basins; antiseptic/alcohol
      handgels that are convenient, effective, and skin- and user-friendly; and
      organisational recognition and support for clinicians in hand washing and handgel
      practices. Yet these all appear to have failed to achieve the required and
      desired compliance in hand hygiene.
FAU - Mortell, Manfred
AU  - Mortell M
AD  - Adult Cardiac Surgical Intensive Care Unit, King Abdulaziz Cardiac Center,
      Riyadh, Kingdom of Suadi Arabia.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Nurs
JT  - British journal of nursing (Mark Allen Publishing)
JID - 9212059
MH  - *Ethics, Clinical
MH  - Evidence-Based Practice
MH  - *Guideline Adherence
MH  - *Hand Hygiene
MH  - Humans
EDAT- 2012/11/06 06:00
MHDA- 2012/12/29 06:00
CRDT- 2012/11/06 06:00
PHST- 2012/11/06 06:00 [entrez]
PHST- 2012/11/06 06:00 [pubmed]
PHST- 2012/12/29 06:00 [medline]
AID - 10.12968/bjon.2012.21.17.1011 [doi]
PST - ppublish
SO  - Br J Nurs. 2012 Sep 27-Oct 10;21(17):1011-4. doi: 10.12968/bjon.2012.21.17.1011.


PMID- 23123034
OWN - NLM
STAT- MEDLINE
DCOM- 20130916
LR  - 20181202
IS  - 1873-491X (Electronic)
IS  - 0020-7489 (Linking)
VI  - 50
IP  - 5
DP  - 2013 May
TI  - Nurses' decision-making process in cases of physical restraint in acute elderly
      care: a qualitative study.
PG  - 603-12
LID - 10.1016/j.ijnurstu.2012.10.006 [doi]
LID - S0020-7489(12)00337-9 [pii]
AB  - BACKGROUND: The increasing vulnerability of patients in acute elderly care
      requires constant critical reflection in ethically charged situations such as
      when employing physical restraint. Qualitative evidence concerning nurses'
      decision making in cases of physical restraint is limited and fragmented. A
      thorough understanding of nurses' decision-making process could be useful to
      understand how nurses reason and make decisions in ethically laden situations.
      OBJECTIVES: The aims of this study were to explore and describe nurses'
      decision-making process in cases of physical restraint. DESIGN: We used a
      qualitative interview design inspired by the Grounded Theory approach. Data
      analysis was guided by the Qualitative Analysis Guide of Leuven. SETTING: Twelve 
      hospitals geographically spread throughout the five provinces of Flanders,
      Belgium. PARTICIPANTS: Twenty-one acute geriatric nurses interviewed between
      October 2009 and April 2011 were purposively and theoretically selected, with the
      aim of including nurses having a variety of characteristics and experiences
      concerning decisions on using physical restraint. RESULTS: In cases of physical
      restraint in acute elderly care, nurses' decision making was never experienced as
      a fixed decision but rather as a series of decisions. Decision making was mostly 
      reasoned upon and based on rational arguments; however, decisions were also made 
      routinely and intuitively. Some nurses felt very certain about their decisions,
      while others experienced feelings of uncertainty regarding their decisions.
      CONCLUSIONS: Nurses' decision making is an independent process that requires
      nurses to obtain a good picture of the patient, to be constantly observant, and
      to assess and reassess the patient's situation. Coming to thoughtful and
      individualized decisions requires major commitment and constant critical
      reflection.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Goethals, S
AU  - Goethals S
AD  - Department of Nursing, Catholic University College Ghent, Belgium.
      sabine.goethals@kahosl.be
FAU - Dierckx de Casterle, B
AU  - Dierckx de Casterle B
FAU - Gastmans, C
AU  - Gastmans C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121102
PL  - England
TA  - Int J Nurs Stud
JT  - International journal of nursing studies
JID - 0400675
SB  - IM
MH  - Aged
MH  - Belgium
MH  - *Decision Making
MH  - Geriatric Nursing
MH  - Humans
MH  - Nursing Staff, Hospital/*psychology
MH  - Qualitative Research
MH  - *Restraint, Physical
MH  - Workforce
EDAT- 2012/11/06 06:00
MHDA- 2013/09/17 06:00
CRDT- 2012/11/06 06:00
PHST- 2011/12/01 00:00 [received]
PHST- 2012/10/02 00:00 [revised]
PHST- 2012/10/08 00:00 [accepted]
PHST- 2012/11/06 06:00 [entrez]
PHST- 2012/11/06 06:00 [pubmed]
PHST- 2013/09/17 06:00 [medline]
AID - S0020-7489(12)00337-9 [pii]
AID - 10.1016/j.ijnurstu.2012.10.006 [doi]
PST - ppublish
SO  - Int J Nurs Stud. 2013 May;50(5):603-12. doi: 10.1016/j.ijnurstu.2012.10.006. Epub
      2012 Nov 2.


PMID- 23122976
OWN - NLM
STAT- MEDLINE
DCOM- 20130517
LR  - 20220409
IS  - 1873-4529 (Electronic)
IS  - 0952-8180 (Linking)
VI  - 24
IP  - 8
DP  - 2012 Dec
TI  - A national cross-sectional survey of social networking practices of U.S.
      anesthesiology residency program directors.
PG  - 618-24
LID - 10.1016/j.jclinane.2012.06.002 [doi]
LID - S0952-8180(12)00277-2 [pii]
AB  - STUDY OBJECTIVE: To determine the social networking practices of directors of
      anesthesiology residency programs. DESIGN: Cross-sectional survey. SETTING:
      Online and paper survey tool. SUBJECTS: 132 anesthesiology residency program
      directors in the United States. MEASUREMENTS: A 13-item survey including
      dichotomous and multiple choice responses was administered using an online survey
      tool and a paper survey. Data analysis was conducted by descriptive and
      analytical statistics (chi-square test). A P-value < 0.05 indicated statistical
      significance. MAIN RESULTS: 50% of anesthesiology program directors responded to 
      the survey (66/132). Policies governing social networking practices were in place
      for 30.3% (n=20) of the programs' hospitals. The majority of program directors
      (81.8%, 54) reported never having had an incident involving reprimand of a
      resident or fellow for inappropriate social networking practices. The majority
      (66.7%, n=44) of responding programs reported that departments did not provide
      lectures or educational activities related to appropriate social networking
      practices. Monitoring of social networking habits of residents/fellows by program
      directors mainly occurs if they are alerted to a problem (54.5%, n=36). Frequent 
      use of the Internet for conducting searches on a resident applicant was reported 
      by 12.1% (n=8) of program directors, 30.3% (n=20) reported use a few times, and
      57.6% (n=38) reported never using the Internet in this capacity. CONCLUSION:
      Residency programs should have a written policy related to social media use.
      Residency program directors should be encouraged to become familiar with the
      professionalism issues related to social media use in order to serve as adequate 
      resident mentors within this new and problematic aspect of medical ethics and
      professionalism.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Barker, Andrew L
AU  - Barker AL
AD  - Department of Anesthesiology, Scott & White Healthcare and Texas A&M Health
      Science Center, College of Medicine, Temple, TX 76508, USA.
FAU - Wehbe-Janek, Hania
AU  - Wehbe-Janek H
FAU - Bhandari, Naumit S
AU  - Bhandari NS
FAU - Bittenbinder, Timothy M
AU  - Bittenbinder TM
FAU - Jo, ChanHee
AU  - Jo C
FAU - McAllister, Russell K
AU  - McAllister RK
LA  - eng
PT  - Journal Article
DEP - 20121030
PL  - United States
TA  - J Clin Anesth
JT  - Journal of clinical anesthesia
JID - 8812166
SB  - IM
MH  - Anesthesiology/*education
MH  - Cross-Sectional Studies
MH  - Data Collection
MH  - Humans
MH  - Internet
MH  - Internship and Residency/*statistics & numerical data
MH  - *Organizational Policy
MH  - Social Media/*statistics & numerical data
MH  - United States
EDAT- 2012/11/06 06:00
MHDA- 2013/05/18 06:00
CRDT- 2012/11/06 06:00
PHST- 2011/12/09 00:00 [received]
PHST- 2012/06/26 00:00 [revised]
PHST- 2012/06/28 00:00 [accepted]
PHST- 2012/11/06 06:00 [entrez]
PHST- 2012/11/06 06:00 [pubmed]
PHST- 2013/05/18 06:00 [medline]
AID - S0952-8180(12)00277-2 [pii]
AID - 10.1016/j.jclinane.2012.06.002 [doi]
PST - ppublish
SO  - J Clin Anesth. 2012 Dec;24(8):618-24. doi: 10.1016/j.jclinane.2012.06.002. Epub
      2012 Oct 30.


PMID- 23122215
OWN - NLM
STAT- MEDLINE
DCOM- 20130502
LR  - 20211021
IS  - 1472-6920 (Electronic)
IS  - 1472-6920 (Linking)
VI  - 12
DP  - 2012 Nov 5
TI  - What should we be selecting for? A systematic approach for determining which
      personal characteristics to assess for during admissions.
PG  - 105
LID - 10.1186/1472-6920-12-105 [doi]
AB  - BACKGROUND: Admission committees are responsible for creating fair, defensible,
      reliable, and valid processes that assess those attributes considered important
      for professional success. There is evidence for the continuing use of academic
      ability as a selection criterion for health professional schools; however, there 
      is little evidence for the reliability and validity of measures currently in
      place to assess personal characteristics. The Ontario Veterinary College (OVC)
      initiated a review of its admissions criteria in order to implement an
      evidence-based method to determine which characteristics veterinary stakeholders 
      consider important to assess for admission. METHODS: Eleven characteristics were 
      identified by the OVC Admissions Committee and a survey was sent to all licensed 
      veterinarians in Ontario (n=4,068), OVC students (n=450), and OVC faculty,
      interns and residents (n=192). A paired comparison method was used to identify
      the relative rank order of the characteristics, and multivariate analysis of
      variance with post hoc analyses was used to determine between group differences
      in the returned survey data. RESULTS: Surveys were returned from 1,312
      participants (27.86% response rate; female 59.70%). The relative rank of the
      characteristics was reasonably consistent among participant groups, with ethical 
      behaviour, sound judgment, communication, and critical and creative thinking
      being ranked as the top four. However, the importance of certain characteristics 
      like communication and empathy were perceived differently by groups. For
      instance, females scored communication (F(1, 1289) = 20.24, p < .001, d = .26)
      and empathy (F(1, 1289) = 55.41, p < .001, d = 0.42) significantly higher than
      males, while males scored knowledge of profession (F(1, 1289) = 12.81, p < .001, 
      d = 0.20), leadership (F(1, 1289) = 10.28, p = .001, d = 0.18), and sound
      judgment (F(1, 1289) = 13.56, p < .001, d = 0.21) significantly higher than
      females. CONCLUSIONS: The data from the paired comparison method provide
      convergent evidence for the characteristics participant groups identify as most
      important in determining who should be admitted to a veterinary program. The
      between group analyses provides important information regarding characteristics
      most important to various subgroups; this has implications for what
      characteristics are selected for at admission as well as on who is selecting for 
      them.
FAU - Conlon, Peter
AU  - Conlon P
AD  - Dean's Office, Ontario Veterinary College, University of Guelph, Guelph, ON,
      Canada.
FAU - Hecker, Kent
AU  - Hecker K
FAU - Sabatini, Susan
AU  - Sabatini S
LA  - eng
PT  - Journal Article
DEP - 20121105
PL  - England
TA  - BMC Med Educ
JT  - BMC medical education
JID - 101088679
SB  - IM
MH  - Achievement
MH  - Adult
MH  - *Character
MH  - Clinical Competence
MH  - Communication
MH  - Cooperative Behavior
MH  - Data Collection
MH  - Empathy
MH  - Evidence-Based Practice
MH  - Female
MH  - Humans
MH  - Judgment
MH  - Leadership
MH  - Male
MH  - Middle Aged
MH  - Ontario
MH  - *School Admission Criteria
MH  - *Schools, Veterinary
MH  - Young Adult
PMC - PMC3508846
EDAT- 2012/11/06 06:00
MHDA- 2013/05/03 06:00
CRDT- 2012/11/06 06:00
PHST- 2011/11/14 00:00 [received]
PHST- 2012/10/25 00:00 [accepted]
PHST- 2012/11/06 06:00 [entrez]
PHST- 2012/11/06 06:00 [pubmed]
PHST- 2013/05/03 06:00 [medline]
AID - 1472-6920-12-105 [pii]
AID - 10.1186/1472-6920-12-105 [doi]
PST - epublish
SO  - BMC Med Educ. 2012 Nov 5;12:105. doi: 10.1186/1472-6920-12-105.


PMID- 23121880
OWN - NLM
STAT- MEDLINE
DCOM- 20130401
LR  - 20130404
IS  - 0033-0205 (Print)
IS  - 0033-0205 (Linking)
VI  - 65
IP  - 3
DP  - 2012 Jul-Sep
TI  - [Exploring moral distress among clinical nurses].
PG  - 155-62
AB  - Moral distress in nursing practice is described as a suffering situation that
      arises when the nurse is unable to act her/his ethical choices, when
      institutional constraints interfere with acting in the way she/he believes to be 
      right. The aim is to describe nursing practice situations causing moral distress 
      resulting from the recognition of the ethical appropriate actions combined with
      the impossibility to pursue it; to describe how nurses manage moral distress
      situations and the strategies to cope with them. A focus group was conducted in
      three wards of a large teaching-hospital in the north of Italy. In another ward
      the nurses were asked to write a moral distress experience. A total of 40 nurses 
      were involved and 50 experiences collected. The experiences' analysis has shown 5
      source areas of moral distress: 1) clinical decision; 2) nursing competences; 3) 
      nurse-physician collaboration; 4) organization of care; 5) safe care. For each
      area the most frequent themes were highlighted.Areas of clinical decision,
      nursing competences, nurse-physician collaboration involve nurse leaders in
      identification and implementation of strategies for managing moral distress.
FAU - Lovato, Sabrina
AU  - Lovato S
AD  - Unita Coronarica Azienda Ospedaliera Universitaria Integrata Verona, Docente di
      Bioetica, Corso di Laurea in Infermieristica, Universita degli Studi di Verona.
      sabrina.lovato@ospedaleuniverona.it [corrected]
FAU - Cunico, Laura
AU  - Cunico L
LA  - ita
PT  - English Abstract
PT  - Journal Article
TT  - Esplorando il distress morale tra gli infermieri clinici.
PL  - Italy
TA  - Prof Inferm
JT  - Professioni infermieristiche
JID - 0244135
EIN - Prof Inferm. 2012 Oct-Dec;65(4):4 p following 252. Lovato, Liliana [corrected to 
      Lovato, Sabrina]
MH  - *Ethics, Nursing
MH  - Humans
MH  - *Morals
MH  - *Nursing
MH  - Nursing Staff, Hospital
MH  - *Stress, Psychological/etiology
EDAT- 2012/11/06 06:00
MHDA- 2013/04/02 06:00
CRDT- 2012/11/06 06:00
PHST- 2012/11/06 06:00 [entrez]
PHST- 2012/11/06 06:00 [pubmed]
PHST- 2013/04/02 06:00 [medline]
PST - ppublish
SO  - Prof Inferm. 2012 Jul-Sep;65(3):155-62.


PMID- 23121745
OWN - NLM
STAT- MEDLINE
DCOM- 20130103
LR  - 20211021
IS  - 1916-9736 (Print)
IS  - 1916-9736 (Linking)
VI  - 4
IP  - 6
DP  - 2012 Aug 30
TI  - Assisted or hastened death: the healthcare practitioner's dilemma.
PG  - 87-98
LID - 10.5539/gjhs.v4n6p87 [doi]
AB  - Assisting or hastening death is a dilemma with many ethical as well as practical 
      issues facing healthcare practitioners in many countries worldwide now. Various
      arguments for and against assisted dying have been made over time but the call
      from the public for legalisation of euthanasia or assisted suicide has never been
      stronger. While many studies have documented the reluctance of medical and other 
      health professionals to be involved in the practice of assisted dying or
      euthanasia, there is still much open debate in the public domain. Those who have 
      the most experience of palliative care are strongest in their opposition to
      assisted death or euthanasia. This paper explores salient practical and ethical
      considerations for healthcare practitioners associated with assisted death, with 
      a focus on examining the concepts of autonomy for patients and healthcare
      practitioners. The role of the healthcare practitioner has clearly and
      undoubtedly changed over time with advances in healthcare practices but the duty 
      of care has not changed. The dilemmas for healthcare practitioners thus who have 
      competent patients requesting hastened death extends far beyond acting within a
      country's laws as they go to the very heart of the relationship between the
      practitioner and patient.
FAU - Macleod, Rod Duncan
AU  - Macleod RD
AD  - University of Sydney, Sydney, Australia. rmacleod@hammond.com.au
FAU - Wilson, Donna M
AU  - Wilson DM
FAU - Malpas, Phillipa
AU  - Malpas P
LA  - eng
PT  - Journal Article
DEP - 20120830
PL  - Canada
TA  - Glob J Health Sci
JT  - Global journal of health science
JID - 101519495
SB  - IM
MH  - Euthanasia/*ethics/psychology
MH  - Health Personnel/*ethics/psychology
MH  - Humans
MH  - Palliative Care/ethics
MH  - Personal Autonomy
MH  - Professional Role
MH  - Suicide, Assisted/*ethics/psychology
PMC - PMC4776959
EDAT- 2012/11/06 06:00
MHDA- 2013/01/04 06:00
CRDT- 2012/11/06 06:00
PHST- 2012/07/31 00:00 [received]
PHST- 2012/08/14 00:00 [accepted]
PHST- 2012/11/06 06:00 [entrez]
PHST- 2012/11/06 06:00 [pubmed]
PHST- 2013/01/04 06:00 [medline]
AID - 10.5539/gjhs.v4n6p87 [doi]
PST - epublish
SO  - Glob J Health Sci. 2012 Aug 30;4(6):87-98. doi: 10.5539/gjhs.v4n6p87.


PMID- 23121738
OWN - NLM
STAT- MEDLINE
DCOM- 20130103
LR  - 20211021
IS  - 1916-9736 (Print)
IS  - 1916-9736 (Linking)
VI  - 4
IP  - 6
DP  - 2012 Aug 15
TI  - Cost burden of post stroke condition in Nigeria: a pilot study.
PG  - 17-22
LID - 10.5539/gjhs.v4n6p17 [doi]
AB  - AIM: Estimation of cost burden of a disease condition is a very important part of
      health care policy making worldwide. Till now, such documents are lacking
      especially on non-communicable diseases in the health policy making process in
      Nigeria. This article therefore attempts to report the results of a prospective
      cross-sectional study on the cost burden of a cerebrovascular accident condition 
      (stroke) in Nigeria. It estimates the direct health care cost for a minimum
      period of 12 weeks and maximum of 36 weeks for post stroke hemiplegia. STUDY
      DESIGN/SETTING: It was a collaborative cross-sectional study amongst centers
      situated in urban and sub-urban environments in Southern Nigeria. It involved a
      hospital of an Oil and Gas Company in Port Harcourt, Nigeria, two Government
      tertiary hospitals in Port Harcourt and Benin-City, all in South-South Nigeria,
      the industrial hub of the country. A Private Specialist hospital in Lagos,
      South-West Nigeria, the corporate hub of the country was also included. METHOD:
      Patients diagnosed and admitted for management for cerebrovascular accident
      (stroke) in the above named health facilities formed the subjects of this study. 
      Medical records (case files) of two hundred and forty (240) stroke patients
      managed within the last six years (2005- 2011) were randomly selected from the
      medical record departments of the study centers. Files of the patients who were
      admitted during acute care period (without discharge against medical advice) and 
      were followed on out-patient basis without default within the study period were
      purposively utilized. The files were then assessed for the various investigations
      and treatment interventions of acute and long term care and the costs thereof.
      Ethical approval to access patients' case files was sought and granted by the
      Research Ethics Committee of the different study centers. RESULTS: The results
      revealed that it requires an average of N95,100: 00 ($600 ) and N767,900: 00
      ($4860)in a government and a private hospital, respectively to access care within
      the first 36 weeks of post stroke affectation in Nigeria. CONCLUSION: The outcome
      of this study suggests that managing stroke constitutes a huge direct cost burden
      unaffordable by an average Nigerian stroke sufferer. The implication is that lack
      of means for rehabilitative care may result in disability adjusted life years
      which further compounds burdens in terms of indirect cost on the sufferers' and
      care givers' productivity. It is therefore recommended that awareness of this
      disorder is created by policy makers and implementers where it does not exist and
      increased where it does with health promotion and preventive measures.
FAU - Birabi, Bridget N
AU  - Birabi BN
AD  - Department of Physiotherapy, University of Benin Teaching Hospital, Benin City,
      Nigeria.
FAU - Oke, Kayode Israel
AU  - Oke KI
FAU - Dienye, Paul O
AU  - Dienye PO
FAU - Okafor, Udoka Chris
AU  - Okafor UC
LA  - eng
PT  - Journal Article
DEP - 20120815
PL  - Canada
TA  - Glob J Health Sci
JT  - Global journal of health science
JID - 101519495
SB  - IM
MH  - Adult
MH  - Cross-Sectional Studies
MH  - Female
MH  - Health Expenditures/*statistics & numerical data
MH  - Health Policy
MH  - Hospitals, Private/*economics
MH  - Hospitals, Public/*economics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nigeria/epidemiology
MH  - Prospective Studies
MH  - Stroke/*economics/epidemiology
PMC - PMC4776983
EDAT- 2012/11/06 06:00
MHDA- 2013/01/04 06:00
CRDT- 2012/11/06 06:00
PHST- 2012/07/06 00:00 [received]
PHST- 2012/07/22 00:00 [accepted]
PHST- 2012/11/06 06:00 [entrez]
PHST- 2012/11/06 06:00 [pubmed]
PHST- 2013/01/04 06:00 [medline]
AID - 10.5539/gjhs.v4n6p17 [doi]
PST - epublish
SO  - Glob J Health Sci. 2012 Aug 15;4(6):17-22. doi: 10.5539/gjhs.v4n6p17.


PMID- 23121275
OWN - NLM
STAT- MEDLINE
DCOM- 20130418
LR  - 20211021
IS  - 1751-2441 (Electronic)
IS  - 1751-2433 (Linking)
VI  - 5
IP  - 5
DP  - 2012 Sep
TI  - Evidence-based guidelines for pediatric clinical trials: focus on StaR Child
      Health.
PG  - 525-31
LID - 10.1586/ecp.12.52 [doi]
AB  - Clinical trials in children are challenging and filled with important ethical
      considerations that differ from adults. Given difficulties associated with
      pediatric clinical trials, off-label prescribing is a common practice in
      pediatrics, which can lead to adverse safety events and efficacy failures. To
      overcome these consequences, in the past 15 years, legislation in the USA and
      Europe has provided incentives to industry and increased government funding to
      conduct pediatric trials. Pediatric trial networks have also been formed to
      decrease the knowledge gap. However, challenges to performing pediatric trials
      and lack of standardization and guidelines regarding studies in children still
      exist. Standards for Research (StaR) in Child Health, begun in 2009, aims to
      improve the design, conduct and reporting of pediatric trials. This organization 
      uses a consensus guideline approach involving academic, government and industry
      stakeholders to identify and disseminate best practices for pediatric trials. Six
      out of 11 planned standards are currently published.
FAU - Sampson, Mario R
AU  - Sampson MR
AD  - Duke Clinical Research Institute, Durham, 2400 Pratt Street, Durham, NC 27705,
      USA.
FAU - Benjamin, Daniel K
AU  - Benjamin DK
FAU - Cohen-Wolkowiez, Michael
AU  - Cohen-Wolkowiez M
LA  - eng
GR  - HHSN267200700051C/HD/NICHD NIH HHS/United States
GR  - K24 HD058735/HD/NICHD NIH HHS/United States
GR  - 1K23HD064814-01/HD/NICHD NIH HHS/United States
GR  - R01 HD057956/HD/NICHD NIH HHS/United States
GR  - 1R01HD057956-02/HD/NICHD NIH HHS/United States
GR  - 1 T32 GM 86330-1 A1/GM/NIGMS NIH HHS/United States
GR  - K23 HD064814/HD/NICHD NIH HHS/United States
GR  - U10 HD045962/HD/NICHD NIH HHS/United States
GR  - R01FD003519-01/FD/FDA HHS/United States
GR  - 1K24HD058735-01/HD/NICHD NIH HHS/United States
GR  - R01 FD003519/FD/FDA HHS/United States
GR  - T32 GM086330/GM/NIGMS NIH HHS/United States
GR  - 1U10-HD45962-06/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - Expert Rev Clin Pharmacol
JT  - Expert review of clinical pharmacology
JID - 101278296
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Adolescent
MH  - Biomedical Research/legislation & jurisprudence/*methods/standards
MH  - Child
MH  - Child Welfare
MH  - Child, Preschool
MH  - Clinical Trials as Topic/legislation & jurisprudence/*methods/standards
MH  - Dose-Response Relationship, Drug
MH  - Humans
MH  - Infant
MH  - Pediatrics
MH  - Pharmaceutical Preparations/administration & dosage/standards
MH  - *Practice Guidelines as Topic
MH  - Research Design/legislation & jurisprudence/standards
PMC - PMC3566240
MID - NIHMS436068
EDAT- 2012/11/06 06:00
MHDA- 2013/04/20 06:00
CRDT- 2012/11/06 06:00
PHST- 2012/11/06 06:00 [entrez]
PHST- 2012/11/06 06:00 [pubmed]
PHST- 2013/04/20 06:00 [medline]
AID - 10.1586/ecp.12.52 [doi]
PST - ppublish
SO  - Expert Rev Clin Pharmacol. 2012 Sep;5(5):525-31. doi: 10.1586/ecp.12.52.


PMID- 23121079
OWN - NLM
STAT- MEDLINE
DCOM- 20140306
LR  - 20161125
IS  - 1399-0004 (Electronic)
IS  - 0009-9163 (Linking)
VI  - 84
IP  - 3
DP  - 2013 Sep
TI  - To tell or not to tell - what to do about p.C282Y heterozygotes identified by HFE
      screening.
PG  - 286-9
LID - 10.1111/cge.12053 [doi]
AB  - Hereditary hemochromatosis (HH) is a common preventable disorder of iron overload
      that can result in liver cirrhosis and reduced lifespan. Most HH is due to
      homozygosity for the HFE p.C282Y substitution. We conducted a study of screening 
      for p.C282Y in high schools where p.C282Y heterozygotes (CY) individuals were
      informed of their genotype by letter. We studied whether these individuals
      understood the implications of their genotype, whether this resulted in anxiety
      or reduced health perception and whether cascade testing was higher in families
      of CY than wild-type homozygous (CC) individuals. We found 586 of 5757 (1 in 10) 
      screened individuals were CY. One month after receiving their result, 83%
      correctly answered that they have one copy of p.C282Y. There was no adverse
      change in anxiety or health perception from prior to screening to 1 month after
      receiving results. Significantly more family members of CY individuals than CC
      individuals were informed about HH and had testing for HH. In conclusion, we
      found that informing CY individuals of their genotype does not increase anxiety
      and the implications are generally well understood. This leads to cascade testing
      in a minority of families. CY individuals should be informed of their genetic
      status when identified by population screening.
CI  - (c) 2012 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Delatycki, M B
AU  - Delatycki MB
AD  - Murdoch Childrens Research Institute, Parkville, Victoria, Australia.
      martin.delatycki@ghsv.org.au
FAU - Wolthuizen, M
AU  - Wolthuizen M
FAU - Aitken, M A
AU  - Aitken MA
FAU - Hickerton, C
AU  - Hickerton C
FAU - Metcalfe, S A
AU  - Metcalfe SA
FAU - Allen, K J
AU  - Allen KJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121127
PL  - Denmark
TA  - Clin Genet
JT  - Clinical genetics
JID - 0253664
RN  - 0 (HFE protein, human)
RN  - 0 (Hemochromatosis Protein)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Membrane Proteins)
SB  - IM
MH  - Disclosure/*ethics
MH  - Hemochromatosis/diagnosis/*genetics/*psychology
MH  - Hemochromatosis Protein
MH  - *Heterozygote
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Membrane Proteins/*genetics
MH  - *Mutation
MH  - Students
MH  - Surveys and Questionnaires
OTO - NOTNLM
OT  - ethics
OT  - genetic screening
OT  - harm
OT  - hemochromatosis
OT  - heterozygote
OT  - informed consent
EDAT- 2012/11/06 06:00
MHDA- 2014/03/07 06:00
CRDT- 2012/11/06 06:00
PHST- 2012/08/28 00:00 [received]
PHST- 2012/10/30 00:00 [revised]
PHST- 2012/10/30 00:00 [accepted]
PHST- 2012/11/06 06:00 [entrez]
PHST- 2012/11/06 06:00 [pubmed]
PHST- 2014/03/07 06:00 [medline]
AID - 10.1111/cge.12053 [doi]
PST - ppublish
SO  - Clin Genet. 2013 Sep;84(3):286-9. doi: 10.1111/cge.12053. Epub 2012 Nov 27.


PMID- 23118669
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121105
LR  - 20211021
IS  - 2331-348X (Electronic)
IS  - 1551-6776 (Linking)
VI  - 17
IP  - 2
DP  - 2012 Apr
TI  - Implementation of a standardized process for ordering and dispensing of
      high-alert emergency medication infusions.
PG  - 166-72
LID - 10.5863/1551-6776-17.2.166 [doi]
AB  - OBJECTIVES: Pharmacies encounter challenges when ensuring safe, timely medication
      dispensing to patients in the pediatric intensive care unit, when high-alert
      medications are needed in emergent situations. Removal of these medications from 
      nursing stock presented challenges to providing timely administration to critical
      patients. The project's purpose was to develop a new method for reducing
      dispensing time while improving patient safety in pediatric intensive care units.
      METHODS: A committee of physicians, nurses, a clinical pharmacist, and pharmacy
      administration collaborated for process development. The process established a
      list of compounded, ready-to-use infusions stored in the pharmacy, immediately
      available for dispensing. The dispensing mechanism includes ordering and
      dispensing processes using an "Urgent Drip Request" form. Most frequently ordered
      infusions (dopamine, epinephrine, norepinephrine) were added to automated
      dispensing cabinets in critical care units in concentrations that could be safely
      infused centrally or peripherally. RESULTS: During the initial 4 months, 71
      "Urgent Drip Request" sheets were processed. Drug utilization evaluation
      demonstrated a dispensing time of less than 1 minute for drip medications leaving
      the pharmacy after the form was received. No sheets processed exceeded the
      institutional 30-minute turnaround time, nor were errors or delays documented.
      Limited turnaround time data existed preimplementation but was not robust enough 
      for analysis. It was not ethically feasible to perform a head-to-head comparison 
      with the previous method, as it might have resulted in delay of therapy and
      negative patient outcomes. CONCLUSIONS: This program allows high-alert medication
      infusion availability in an expedited manner, removes potential for compounding
      errors at the bedside, and assures clean room preparation. This has improved
      pharmacy efficiency in provision of safe patient care to critically ill pediatric
      patients.
FAU - Polischuk, Emily
AU  - Polischuk E
AD  - University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania ;
      Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania.
FAU - Vetterly, Carol G
AU  - Vetterly CG
FAU - Crowley, Kelli L
AU  - Crowley KL
FAU - Thompson, Ann
AU  - Thompson A
FAU - Goff, Jeff
AU  - Goff J
FAU - Nguyen-Ha, Phuong-Tan
AU  - Nguyen-Ha PT
FAU - Modery, Christine
AU  - Modery C
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pediatr Pharmacol Ther
JT  - The journal of pediatric pharmacology and therapeutics : JPPT : the official
      journal of PPAG
JID - 101089851
PMC - PMC3470437
OTO - NOTNLM
OT  - emergency medications
OT  - high-alert medications
OT  - medication safety
OT  - patient safety
OT  - pediatric
EDAT- 2012/11/03 06:00
MHDA- 2012/11/03 06:01
CRDT- 2012/11/03 06:00
PHST- 2012/11/03 06:00 [entrez]
PHST- 2012/11/03 06:00 [pubmed]
PHST- 2012/11/03 06:01 [medline]
AID - 10.5863/1551-6776-17.2.166 [doi]
PST - ppublish
SO  - J Pediatr Pharmacol Ther. 2012 Apr;17(2):166-72. doi: 10.5863/1551-6776-17.2.166.


PMID- 23118469
OWN - NLM
STAT- MEDLINE
DCOM- 20130325
LR  - 20191210
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 2
DP  - 2013 Feb
TI  - Ethics policy review: a case study in quality improvement.
PG  - 98-103
LID - 10.1136/medethics-2011-100461 [doi]
AB  - Policy work is often cited as one of the primary functions of Hospital Ethics
      Committees (HECs), along with consultation and education. Hospital policies can
      have far reaching effects on a wide array of stakeholders including, care
      providers, patients, families, the culture of the organisation and the community 
      at large. In comparison with the wealth of information available about the
      emerging practice of ethics consultation, relatively little attention has been
      paid to the policy work of HECs. In this paper, we hope to advance the
      development of best practices in HEC policy work by describing the quality
      improvement process that we undertook at Hamilton Health Sciences, Hamilton,
      Ontario, Canada. In the first section of the paper we describe the context of our
      HEC policy work, and the shortcomings of our historical review process. In
      subsequent sections, we detail the quality improvement project we undertook in
      2010, the results of the project and the specific tools we developed to enhance
      the quality of HEC policy work. Our goal in sharing this organisational case
      study is to prompt other HECs to publish qualitative descriptions of their policy
      work, in order to generate a body of knowledge that can inform the development of
      best practices for ethics policy review.
FAU - Frolic, Andrea Nadine
AU  - Frolic AN
AD  - Clinical & Organizational Ethics, Hamilton Health Sciences, McMaster University
      Medical Centre, Hamilton, ON, Canada. frolic@hhsc.ca
FAU - Drolet, Katherine
AU  - Drolet K
CN  - HHS Policy Working Group
LA  - eng
PT  - Journal Article
DEP - 20121031
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Ethics Committees, Clinical
MH  - *Ethics Consultation/ethics/standards/trends
MH  - *Ethics, Clinical
MH  - Humans
MH  - Ontario
MH  - Organizational Case Studies
MH  - Outcome and Process Assessment, Health Care
MH  - *Policy Making
MH  - *Quality Improvement
MH  - *Tertiary Care Centers/ethics/standards/trends
IR  - Bryanton K
FIR - Bryanton, Kim
IR  - Caron C
FIR - Caron, Carole
IR  - Cupido C
FIR - Cupido, Cynthia
IR  - Flaherty B
FIR - Flaherty, Barb
IR  - Fung S
FIR - Fung, Sylvia
IR  - McCall L
FIR - McCall, Lori
EDAT- 2012/11/03 06:00
MHDA- 2013/03/26 06:00
CRDT- 2012/11/03 06:00
PHST- 2012/11/03 06:00 [entrez]
PHST- 2012/11/03 06:00 [pubmed]
PHST- 2013/03/26 06:00 [medline]
AID - medethics-2011-100461 [pii]
AID - 10.1136/medethics-2011-100461 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Feb;39(2):98-103. doi: 10.1136/medethics-2011-100461. Epub
      2012 Oct 31.


PMID- 23118468
OWN - NLM
STAT- MEDLINE
DCOM- 20130812
LR  - 20211021
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 6
DP  - 2013 Jun
TI  - Unrealistic optimism and the ethics of phase I cancer research.
PG  - 403-6
LID - 10.1136/medethics-2012-100752 [doi]
AB  - One of the most pressing ethical challenges facing phase I cancer research
      centres is the process of informed consent. Historically, most scholarship has
      been devoted to redressing therapeutic misconception, that is, the conflation of 
      the nature and goals of research with those of therapy. While therapeutic
      misconception continues to be a major ethical concern, recent scholarship has
      begun to recognise that the informed consent process is more complex than merely 
      a transfer of information and therefore cannot be evaluated only according to how
      well an individual understands such information. Other components of
      decision-making operate independently of understanding and yet still may
      compromise the quality of informed consent. Notable among these components is
      unrealistic optimism, an event-specific belief that one has a better chance of
      receiving benefit than others similarly situated. In this article, we consider
      responses to interviews with parents who had recently completed an informed
      consent conference for enrolling their child in a phase I cancer clinical trial
      to examine how this influence manifests and how investigators might address it
      during informed consent.
FAU - Crites, Joshua
AU  - Crites J
AD  - Center for Ethics, Humanities, and Spiritual Care, Cleveland Clinic, 9500 Euclid 
      Ave, Cleveland, OH 44195, USA.
FAU - Kodish, Eric
AU  - Kodish E
LA  - eng
GR  - R01 CA122217/CA/NCI NIH HHS/United States
GR  - 1R01CA122217/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20121031
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
CIN - J Med Ethics. 2013 Jun;39(6):407. PMID: 23175460
MH  - Clinical Trials, Phase I as Topic/*ethics
MH  - Comprehension
MH  - *Decision Making
MH  - Ethics, Research
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Neoplasms/*therapy
MH  - Parents
MH  - Patient Selection/ethics
MH  - *Personal Autonomy
MH  - Research Personnel/*ethics
MH  - *Therapeutic Misconception
MH  - Thinking
MH  - Uncertainty
PMC - PMC3697015
MID - NIHMS470514
OTO - NOTNLM
OT  - Research Ethics
EDAT- 2012/11/03 06:00
MHDA- 2013/08/13 06:00
CRDT- 2012/11/03 06:00
PHST- 2012/11/03 06:00 [entrez]
PHST- 2012/11/03 06:00 [pubmed]
PHST- 2013/08/13 06:00 [medline]
AID - medethics-2012-100752 [pii]
AID - 10.1136/medethics-2012-100752 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Jun;39(6):403-6. doi: 10.1136/medethics-2012-100752. Epub 2012
      Oct 31.


PMID- 23118467
OWN - NLM
STAT- MEDLINE
DCOM- 20140114
LR  - 20181202
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 8
DP  - 2013 Aug
TI  - Getting the justification for research ethics review right.
PG  - 527-8
LID - 10.1136/medethics-2012-100943 [doi]
AB  - Dyck and Allen claim that the current model for mandatory ethical review of
      research involving human participants is unethical once the harms that accrue
      from the review process are identified. However, the assumptions upon which the
      authors assert that this model of research ethics governance is justified are
      false. In this commentary, I aim to correct these assumptions, and provide the
      right justificatory account of the requirement for research ethics review. This
      account clarifies why the subsequent arguments that Dyck and Allen make in the
      paper lack force, and why the 'governance problem' in research ethics that they
      allude to ought to be explained differently.
FAU - Dunn, Michael
AU  - Dunn M
AD  - The Ethox Centre, Department of Public Health, University of Oxford, Rosemary Rue
      Building, Old Road Campus, Headington, Oxford OX3 7LF, UK.
      michael.dunn@ethox.ox.ac.uk
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20121031
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
CON - J Med Ethics. 2013 Aug;39(8):525-6. PMID: 23033478
MH  - *Beneficence
MH  - Biomedical Research/*ethics
MH  - Ethics Committees, Research/*economics/*ethics
MH  - *Ethics, Research
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - *Personal Autonomy
MH  - Research Personnel/*ethics
MH  - *Social Justice
OTO - NOTNLM
OT  - Ethics Committees/Consultation
OT  - Research Ethics
EDAT- 2012/11/03 06:00
MHDA- 2014/01/15 06:00
CRDT- 2012/11/03 06:00
PHST- 2012/11/03 06:00 [entrez]
PHST- 2012/11/03 06:00 [pubmed]
PHST- 2014/01/15 06:00 [medline]
AID - medethics-2012-100943 [pii]
AID - 10.1136/medethics-2012-100943 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Aug;39(8):527-8. doi: 10.1136/medethics-2012-100943. Epub 2012
      Oct 31.


PMID- 23118239
OWN - NLM
STAT- MEDLINE
DCOM- 20130523
LR  - 20191210
IS  - 1941-2460 (Electronic)
IS  - 0003-0651 (Linking)
VI  - 60
IP  - 6
DP  - 2012 Dec
TI  - Toward an ethics of psychoanalysis: a critical reading of Lacan's ethics.
PG  - 1223-42
LID - 10.1177/0003065112457876 [doi]
AB  - Lacan's seminar The Ethics of Psychoanalysis (1959-1960) pursues, from a Freudian
      perspective, a fundamental philosophical question classically addressed by
      Aristotle's Nichomachean Ethics: How is human life best lived and fulfilled? Is
      there is an ethic of this type intrinsic to psychoanalysis? Lacan placed the
      problem of desire at the center of his Ethics. His notorious self-authorized
      freedom from convention and probable crossing of limits (see Roudinesco 1993) may
      have led mainstream analysts to ignore his admonition: "At every moment we need
      to know what our effective relationship is to the desire to do good, to the
      desire to cure" (Lacan 1959-1960, p. 219). This means that the analyst's desire, 
      as well as the patient's, is always in play in his attempt to sustain an ethical 
      position. An examination of Lacan's seminar highlights this link, but also points
      to a number of unresolved issues. The patient's desire is a complex matter,
      readily entangled in neurotic compromise, defense, and transference, and the
      analyst's commitment to it is also problematic because of the inevitable
      co-presence of his own desire. Lacan suggested that more emphasis be placed in
      training on the desire of the analyst, but beyond that a proposal is advanced for
      the institutionalization of a "third" as reviewer and interlocutor in routine
      analytic practice. Analysis may not be a discipline that can be limited to a
      dyadic treatment relationship.
FAU - Kirshner, Lewis A
AU  - Kirshner LA
AD  - Harvard Medical School, Cambridge, MA 02139, USA. lewis_kirshner@hms.harvard.edu
LA  - eng
PT  - Journal Article
DEP - 20121101
PL  - United States
TA  - J Am Psychoanal Assoc
JT  - Journal of the American Psychoanalytic Association
JID - 7505579
SB  - IM
CIN - J Am Psychoanal Assoc. 2012 Dec;60(6):1221. PMID: 23118234
CIN - J Am Psychoanal Assoc. 2012 Dec;60(6):1259-79; author response 1281-7. PMID:
      23118237
CIN - J Am Psychoanal Assoc. 2012 Dec;60(6):1251-8; author responce 1281-7. PMID:
      23118238
CIN - J Am Psychoanal Assoc. 2012 Dec;60(6):1243-9; author response 1281-7. PMID:
      23118241
CIN - J Am Psychoanal Assoc. 2013 Aug;61(4):NP1-4. PMID: 23918826
CIN - J Am Psychoanal Assoc. 2013 Aug;61(4):NP10-1. PMID: 23918827
MH  - Career Choice
MH  - Countertransference
MH  - Creativity
MH  - Curriculum
MH  - Defense Mechanisms
MH  - Delusions/psychology/therapy
MH  - *Ethics, Medical
MH  - Freudian Theory
MH  - Humans
MH  - Mentors
MH  - Morals
MH  - *Motivation
MH  - Neurotic Disorders/psychology/therapy
MH  - Object Attachment
MH  - Physician-Patient Relations/*ethics
MH  - Power, Psychological
MH  - *Psychoanalytic Theory
MH  - Psychoanalytic Therapy/education/*ethics
MH  - Psychotherapy, Multiple/education/ethics
MH  - Transference, Psychology
MH  - Unconscious, Psychology
EDAT- 2012/11/03 06:00
MHDA- 2013/05/25 06:00
CRDT- 2012/11/03 06:00
PHST- 2012/11/03 06:00 [entrez]
PHST- 2012/11/03 06:00 [pubmed]
PHST- 2013/05/25 06:00 [medline]
AID - 0003065112457876 [pii]
AID - 10.1177/0003065112457876 [doi]
PST - ppublish
SO  - J Am Psychoanal Assoc. 2012 Dec;60(6):1223-42. doi: 10.1177/0003065112457876.
      Epub 2012 Nov 1.


PMID- 23118238
OWN - NLM
STAT- MEDLINE
DCOM- 20130523
LR  - 20181202
IS  - 1941-2460 (Electronic)
IS  - 0003-0651 (Linking)
VI  - 60
IP  - 6
DP  - 2012 Dec
TI  - The flourishing analyst, responsibility, and psychoanalytic ethics: commentary on
      Kirshner.
PG  - 1251-8; author responce 1281-7
LID - 10.1177/0003065112461830 [doi]
FAU - Wilson, Mitchell
AU  - Wilson M
AD  - mdwmd@comcast.net
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20121101
PL  - United States
TA  - J Am Psychoanal Assoc
JT  - Journal of the American Psychoanalytic Association
JID - 7505579
SB  - IM
CON - J Am Psychoanal Assoc. 2012 Dec;60(6):1223-42. PMID: 23118239
MH  - *Ethics, Medical
MH  - Humans
MH  - *Motivation
MH  - Physician-Patient Relations/*ethics
MH  - *Psychoanalytic Theory
MH  - Psychoanalytic Therapy/*ethics
EDAT- 2012/11/03 06:00
MHDA- 2013/05/25 06:00
CRDT- 2012/11/03 06:00
PHST- 2012/11/03 06:00 [entrez]
PHST- 2012/11/03 06:00 [pubmed]
PHST- 2013/05/25 06:00 [medline]
AID - 0003065112461830 [pii]
AID - 10.1177/0003065112461830 [doi]
PST - ppublish
SO  - J Am Psychoanal Assoc. 2012 Dec;60(6):1251-8; author responce 1281-7. doi:
      10.1177/0003065112461830. Epub 2012 Nov 1.


PMID- 23118234
OWN - NLM
STAT- MEDLINE
DCOM- 20130523
LR  - 20181202
IS  - 1941-2460 (Electronic)
IS  - 0003-0651 (Linking)
VI  - 60
IP  - 6
DP  - 2012 Dec
TI  - Toward an ethics of desire for psychoanalysis: introduction to Kirshner.
PG  - 1221
LID - 10.1177/0003065112461277 [doi]
FAU - Rees, Ellen
AU  - Rees E
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20121101
PL  - United States
TA  - J Am Psychoanal Assoc
JT  - Journal of the American Psychoanalytic Association
JID - 7505579
SB  - IM
CON - J Am Psychoanal Assoc. 2012 Dec;60(6):1223-42. PMID: 23118239
MH  - *Ethics, Medical
MH  - Humans
MH  - *Motivation
MH  - Physician-Patient Relations/*ethics
MH  - *Psychoanalytic Theory
MH  - Psychoanalytic Therapy/*ethics
EDAT- 2012/11/03 06:00
MHDA- 2013/05/25 06:00
CRDT- 2012/11/03 06:00
PHST- 2012/11/03 06:00 [entrez]
PHST- 2012/11/03 06:00 [pubmed]
PHST- 2013/05/25 06:00 [medline]
AID - 0003065112461277 [pii]
AID - 10.1177/0003065112461277 [doi]
PST - ppublish
SO  - J Am Psychoanal Assoc. 2012 Dec;60(6):1221. doi: 10.1177/0003065112461277. Epub
      2012 Nov 1.


PMID- 23118147
OWN - NLM
STAT- MEDLINE
DCOM- 20130722
LR  - 20130208
IS  - 1460-2091 (Electronic)
IS  - 0305-7453 (Linking)
VI  - 68
IP  - 3
DP  - 2013 Mar
TI  - Mycobacterium marinum infection in Drosophila melanogaster for antimycobacterial 
      activity assessment.
PG  - 601-9
LID - 10.1093/jac/dks425 [doi]
AB  - OBJECTIVES: The major advantages of Drosophila melanogaster are a
      well-characterized immune system and high degree of susceptibility to
      tuberculosis caused by Mycobacterium marinum. The D. melanogaster-M. marinum
      infection model is gaining momentum as a screening tool because it is genetically
      amenable, low priced, rapid, technically convenient and ethically acceptable. In 
      this context, the aim of this study was to develop a new, effective D.
      melanogaster-M. marinum in vivo efficacy model for antimycobacterial drug
      discovery. METHODS: D. melanogaster were challenged with intra-abdominal
      injections of M. marinum and infected flies were fed with a fly medium containing
      isoniazid, rifampicin, ethambutol, pyrazinamide, amikacin, dinitrobenzamide or
      ampicillin dissolved in DMSO at different concentrations (0, 100 and 500 mg/L).
      Bacterial dissemination in flies was monitored by fluorescence microscopy/cfu
      counts and a fly survival curve was plotted. RESULTS: The D. melanogaster-M.
      marinum model allowed assessment of the effectiveness of antibiotic treatment not
      only with conventional drugs, but also with newly discovered antimycobacterial
      agents. Rifampicin, dinitrobenzamide, amikacin and isoniazid effectively extended
      the life span of infected flies and ethambutol showed slightly improved survival.
      However, M. marinum infection was not cured by ampicillin or pyrazinamide.
      CONCLUSIONS: This D. melanogaster-M. marinum infection/curing methodology may be 
      valuable in the rapid evaluation of the activity of new antimycobacterial agents 
      in drug discovery.
FAU - Oh, Chun-Taek
AU  - Oh CT
AD  - Institut Pasteur Korea, Seongnam-si, Gyeonggi-do, Korea.
FAU - Moon, Cheol
AU  - Moon C
FAU - Choi, Tae Hyun
AU  - Choi TH
FAU - Kim, Byoung Soo
AU  - Kim BS
FAU - Jang, Jichan
AU  - Jang J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121101
PL  - England
TA  - J Antimicrob Chemother
JT  - The Journal of antimicrobial chemotherapy
JID - 7513617
RN  - 0 (Antitubercular Agents)
SB  - IM
MH  - Animals
MH  - Antitubercular Agents/*isolation & purification/pharmacology
MH  - Bacterial Load
MH  - Drosophila melanogaster/*microbiology
MH  - Drug Evaluation, Preclinical/*methods
MH  - Male
MH  - Models, Animal
MH  - Mycobacterium marinum/*drug effects/*pathogenicity
MH  - Survival Analysis
EDAT- 2012/11/03 06:00
MHDA- 2013/07/23 06:00
CRDT- 2012/11/03 06:00
PHST- 2012/11/03 06:00 [entrez]
PHST- 2012/11/03 06:00 [pubmed]
PHST- 2013/07/23 06:00 [medline]
AID - dks425 [pii]
AID - 10.1093/jac/dks425 [doi]
PST - ppublish
SO  - J Antimicrob Chemother. 2013 Mar;68(3):601-9. doi: 10.1093/jac/dks425. Epub 2012 
      Nov 1.


PMID- 23118023
OWN - NLM
STAT- MEDLINE
DCOM- 20131118
LR  - 20220414
IS  - 1532-8457 (Electronic)
IS  - 1043-4542 (Linking)
VI  - 30
IP  - 1
DP  - 2013 Jan-Feb
TI  - A self-care retreat for pediatric hematology oncology nurses.
PG  - 18-23
LID - 10.1177/1043454212461951 [doi]
AB  - Pediatric hematology oncology nurses face a variety of stressors while working in
      this specialty field. Through hematology oncology staff group discussions, nurses
      identified a myriad physical and emotional stressors they experienced, and
      expressed concern regarding possible burnout. They described facing stressors
      related to experiencing loss, grief, moral and ethical dilemmas, and
      administering complex treatment regimens. To address these concerns, a hematology
      oncology nursing supportive care committee envisioned and implemented 3 off-site 
      self-care retreats. The committee's primary purpose was to create a therapeutic
      and supportive environment for all participants, while allowing time for
      relaxation, reflection, and serenity. The primary goals for the retreats were to 
      heal nurses from their reported past trauma and stress and to provide them
      effective coping strategies for the ongoing stressors they will inevitably face. 
      In a collaborative effort, the committee members developed an agenda including
      presentations, group discussions, and relaxation activities. Written evaluations 
      were completed by each participant to assess the benefit of the retreat. Overall 
      feedback was extremely positive, with the majority of the participants finding
      great value in this experience.
FAU - Altounji, Diane
AU  - Altounji D
AD  - Children's Hospital Los Angeles, Los Angeles, CA, USA. daltounji@chla.usc.edu
FAU - Morgan, Helene
AU  - Morgan H
FAU - Grover, Monica
AU  - Grover M
FAU - Daldumyan, Sona
AU  - Daldumyan S
FAU - Secola, Rita
AU  - Secola R
LA  - eng
PT  - Journal Article
DEP - 20121101
PL  - United States
TA  - J Pediatr Oncol Nurs
JT  - Journal of pediatric oncology nursing : official journal of the Association of
      Pediatric Oncology Nurses
JID - 8917825
SB  - IM
MH  - Adaptation, Psychological
MH  - Burnout, Professional/*therapy
MH  - Hematologic Neoplasms/*nursing
MH  - Humans
MH  - Nursing Staff, Hospital/*psychology
MH  - *Oncology Nursing
MH  - *Self Care
MH  - Workforce
EDAT- 2012/11/03 06:00
MHDA- 2013/11/19 06:00
CRDT- 2012/11/03 06:00
PHST- 2012/11/03 06:00 [entrez]
PHST- 2012/11/03 06:00 [pubmed]
PHST- 2013/11/19 06:00 [medline]
AID - 1043454212461951 [pii]
AID - 10.1177/1043454212461951 [doi]
PST - ppublish
SO  - J Pediatr Oncol Nurs. 2013 Jan-Feb;30(1):18-23. doi: 10.1177/1043454212461951.
      Epub 2012 Nov 1.


PMID- 23117734
OWN - NLM
STAT- MEDLINE
DCOM- 20121231
LR  - 20121102
IS  - 0393-5590 (Print)
IS  - 0393-5590 (Linking)
VI  - 29
IP  - 5
DP  - 2012 Sep-Oct
TI  - [Pre-emptive renal transplantation from deceased donor].
PG  - 525-34
AB  - Preemptive transplantation from deceased donors is an important issue due to its 
      ethical and clinical implications. In this paper, two nephrologists discuss the
      problem from different angles, expressing their opinion on specific points and
      highlighting the limitations and advantages. The first point discussed relates to
      the advantages of preemptive renal transplant from a deceased donor versus
      dialysis. The second point considers the possibility that the former could reduce
      the already limited resources for patients on the transplant waiting list. The
      third point discusses whether preemptive transplant should be reserved for
      patients with particular background diseases. The last discussion point relates
      to the possibility that a preemptive program from deceased donors could hamper an
      already limited living donor program. The ethical aspects are examined separately
      by a bioethicist who critically evaluates all discussion points and lists some
      principles that should guide clinicians, before or after starting dialysis, in
      the proper use of renal transplant, an efficacious but scarce resource.
FAU - Maggiore, Umberto
AU  - Maggiore U
AD  - U.O.S. Trapianti Rene-Pancreas, Azienda Ospedaliero-Universitaria di Parma,
      Parma, Italy. umaggiore@ao.pr.it
FAU - Pretagostini, Renzo
AU  - Pretagostini R
FAU - Petrini, Carlo
AU  - Petrini C
FAU - Sandrini, Silvio
AU  - Sandrini S
LA  - ita
PT  - English Abstract
PT  - Journal Article
TT  - Il trapianto pre-emptive da donatore deceduto.
PL  - Italy
TA  - G Ital Nefrol
JT  - Giornale italiano di nefrologia : organo ufficiale della Societa italiana di
      nefrologia
JID - 9426434
SB  - IM
MH  - Cadaver
MH  - Humans
MH  - *Kidney Transplantation
MH  - Renal Dialysis
MH  - Renal Insufficiency, Chronic/*surgery/therapy
MH  - *Tissue Donors
EDAT- 2012/11/03 06:00
MHDA- 2013/01/01 06:00
CRDT- 2012/11/03 06:00
PHST- 2012/11/03 06:00 [entrez]
PHST- 2012/11/03 06:00 [pubmed]
PHST- 2013/01/01 06:00 [medline]
PST - ppublish
SO  - G Ital Nefrol. 2012 Sep-Oct;29(5):525-34.


PMID- 23117571
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121105
LR  - 20220309
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 6
DP  - 2012
TI  - Observational Research in Childhood Infectious Diseases (ORChID): a dynamic birth
      cohort study.
LID - 10.1136/bmjopen-2012-002134 [doi]
LID - e002134 [pii]
AB  - INTRODUCTION: Even in developed economies infectious diseases remain the most
      common cause of illness in early childhood. Our current understanding of the
      epidemiology of these infections is limited by reliance on data from decades ago 
      performed using low-sensitivity laboratory methods, and recent studies reporting 
      severe, hospital-managed disease. METHODS AND ANALYSIS: The Observational
      Research in Childhood Infectious Diseases (ORChID) study is an ongoing study
      enrolling a dynamic birth cohort to document the community-based epidemiology of 
      viral respiratory and gastrointestinal infections in early childhood. Women are
      recruited antenatally, and their healthy newborn is followed for the first 2
      years of life. Parents keep a daily symptom diary for the study child, collect a 
      weekly anterior nose swab and dirty nappy swab and complete a burden diary when a
      child meets pre-defined illness criteria. Specimens will be tested for a wide
      range of viruses by real-time PCR assays. Primary analyses involves calculating
      incidence rates for acute respiratory illness (ARI) and acute gastroenteritis
      (AGE) for the cohort by age and seasonality. Control material from children when 
      they are without symptoms will allow us to determine what proportion of ARIs and 
      AGE can be attributed to specific pathogens. Secondary analyses will assess the
      incidence and shedding duration of specific respiratory and gastrointestinal
      pathogens. ETHICS AND DISSEMINATION: This study is approved by The Human Research
      Ethics Committees of the Children's Health Queensland Hospital and Health
      Service, the Royal Brisbane and Women's Hospital and The University of
      Queensland. TRIAL REGISTRATION: clinicaltrials.gov NCT01304914.
FAU - Lambert, Stephen Bernard
AU  - Lambert SB
AD  - Queensland Paediatric Infectious Diseases Laboratory, Queensland Children's
      Medical Research Institute, The University of Queensland and the Royal Children's
      Hospital, Brisbane, Queensland, Australia.
FAU - Ware, Robert S
AU  - Ware RS
FAU - Cook, Anne L
AU  - Cook AL
FAU - Maguire, Frances A
AU  - Maguire FA
FAU - Whiley, David M
AU  - Whiley DM
FAU - Bialasiewicz, Seweryn
AU  - Bialasiewicz S
FAU - Mackay, Ian M
AU  - Mackay IM
FAU - Wang, David
AU  - Wang D
FAU - Sloots, Theo P
AU  - Sloots TP
FAU - Nissen, Michael D
AU  - Nissen MD
FAU - Grimwood, Keith
AU  - Grimwood K
LA  - eng
SI  - ClinicalTrials.gov/NCT01304914
PT  - Journal Article
DEP - 20121031
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3547315
EDAT- 2012/11/03 06:00
MHDA- 2012/11/03 06:01
CRDT- 2012/11/03 06:00
PHST- 2012/11/03 06:00 [entrez]
PHST- 2012/11/03 06:00 [pubmed]
PHST- 2012/11/03 06:01 [medline]
AID - bmjopen-2012-002134 [pii]
AID - 10.1136/bmjopen-2012-002134 [doi]
PST - epublish
SO  - BMJ Open. 2012 Oct 31;2(6). pii: bmjopen-2012-002134. doi:
      10.1136/bmjopen-2012-002134. Print 2012.


PMID- 23117077
OWN - NLM
STAT- MEDLINE
DCOM- 20130521
LR  - 20121218
IS  - 1559-2030 (Electronic)
IS  - 1551-7144 (Linking)
VI  - 34
IP  - 1
DP  - 2013 Jan
TI  - The need for expanded monitoring of adverse events in behavioral health clinical 
      trials.
PG  - 152-4
LID - 10.1016/j.cct.2012.10.009 [doi]
LID - S1551-7144(12)00236-4 [pii]
AB  - Monitoring for possible adverse events is ethically required by Institutional
      Review Boards and Good Clinical Practice guidelines for all human research
      involving the delivery of treatment interventions in a clinical trial. The
      monitoring of adverse events is a well-established and routine practice for
      contemporary clinical trials involving medications and medical devices. However, 
      these same guidelines have not been fully integrated into clinical trials
      involving the use of behavioral health interventions and psychotherapy. Most
      behavioral health clinical trials limit adverse event monitoring to serious
      adverse events such as suicide attempts, completed suicides, and psychiatric
      hospitalizations. Other possible "side effects" of psychotherapy, such as
      temporary increases in anxiety, are often considered a normal part of therapy and
      are therefore not documented as possible adverse events. This manuscript reviews 
      a variety of reasons for the limited adverse event monitoring in behavioral
      health clinical trials and highlights the importance of incorporating expanded
      adverse event monitoring into future behavioral health clinical trials. Without
      understanding the nature and prevalence of adverse events, patients cannot be
      informed adequately of the possible risks and benefits of behavioral
      interventions prior to engaging in treatment.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Peterson, Alan L
AU  - Peterson AL
AD  - Department of Psychiatry, University of Texas Health Science Center at San
      Antonio, TX 78229-3900,USA. petersona3@uthscsa.edu
FAU - Roache, John D
AU  - Roache JD
FAU - Raj, Jeslina
AU  - Raj J
FAU - Young-McCaughan, Stacey
AU  - Young-McCaughan S
CN  - STRONG STAR Consortium
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20121029
PL  - United States
TA  - Contemp Clin Trials
JT  - Contemporary clinical trials
JID - 101242342
SB  - IM
MH  - Behavior Control/*methods
MH  - *Clinical Trials Data Monitoring Committees
MH  - Clinical Trials as Topic/*methods
MH  - Humans
MH  - *Psychotherapeutic Processes
MH  - Psychotic Disorders/psychology/*therapy
EDAT- 2012/11/03 06:00
MHDA- 2013/05/23 06:00
CRDT- 2012/11/03 06:00
PHST- 2012/04/19 00:00 [received]
PHST- 2012/08/25 00:00 [revised]
PHST- 2012/10/10 00:00 [accepted]
PHST- 2012/11/03 06:00 [entrez]
PHST- 2012/11/03 06:00 [pubmed]
PHST- 2013/05/23 06:00 [medline]
AID - S1551-7144(12)00236-4 [pii]
AID - 10.1016/j.cct.2012.10.009 [doi]
PST - ppublish
SO  - Contemp Clin Trials. 2013 Jan;34(1):152-4. doi: 10.1016/j.cct.2012.10.009. Epub
      2012 Oct 29.


PMID- 23116953
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130424
LR  - 20130919
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 14
IP  - 2
DP  - 2012 Feb 1
TI  - Barriers and biases: ethical considerations for providing emergency contraception
      to adolescents in the emergency department.
PG  - 121-5
LID - 10.1001/virtualmentor.2012.14.2.jdsc1-1202 [doi]
LID - virtualmentor.2012.14.2.jdsc1-1202 [pii]
FAU - Thilo, Rebecca C
AU  - Thilo RC
AD  - Medical Ethics Track at Baylor College of Medicine, Houston, Texas, USA.
LA  - eng
PT  - Comment
PT  - Journal Article
DEP - 20120201
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
CON - Acad Emerg Med. 2011 Jun;18(6):605-12. PMID: 21676058
EDAT- 2012/11/03 06:00
MHDA- 2012/11/03 06:01
CRDT- 2012/11/03 06:00
PHST- 2012/11/03 06:00 [entrez]
PHST- 2012/11/03 06:00 [pubmed]
PHST- 2012/11/03 06:01 [medline]
AID - virtualmentor.2012.14.2.jdsc1-1202 [pii]
AID - 10.1001/virtualmentor.2012.14.2.jdsc1-1202 [doi]
PST - epublish
SO  - Virtual Mentor. 2012 Feb 1;14(2):121-5. doi:
      10.1001/virtualmentor.2012.14.2.jdsc1-1202.


PMID- 23116952
OWN - NLM
STAT- MEDLINE
DCOM- 20130424
LR  - 20130919
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 14
IP  - 2
DP  - 2012 Feb 1
TI  - The American Medical Association Code of Medical Ethics' opinions on confidential
      care for sexually active minors and physicians' exercise of conscience in refusal
      of services.
PG  - 118-20
LID - 10.1001/virtualmentor.2012.14.2.coet1-1202 [doi]
LID - virtualmentor.2012.14.2.coet1-1202 [pii]
LA  - eng
PT  - Journal Article
DEP - 20120201
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
SB  - IM
MH  - Abortion, Eugenic/legislation & jurisprudence
MH  - Abortion, Induced/*ethics/*legislation & jurisprudence
MH  - *American Medical Association
MH  - Codes of Ethics/*legislation & jurisprudence
MH  - Confidentiality/*ethics/*legislation & jurisprudence
MH  - *Conscience
MH  - *Ethics, Medical
MH  - Female
MH  - Genetic Counseling/ethics/legislation & jurisprudence
MH  - Humans
MH  - Infant, Newborn
MH  - Minors/*legislation & jurisprudence
MH  - Parental Consent/ethics/legislation & jurisprudence
MH  - Personal Autonomy
MH  - Physician-Patient Relations
MH  - Pregnancy
MH  - Refusal to Treat/*ethics/*legislation & jurisprudence
MH  - Reproductive Medicine/*ethics/*legislation & jurisprudence
MH  - *Sexual Behavior
MH  - United States
EDAT- 2012/11/03 06:00
MHDA- 2013/04/25 06:00
CRDT- 2012/11/03 06:00
PHST- 2012/11/03 06:00 [entrez]
PHST- 2012/11/03 06:00 [pubmed]
PHST- 2013/04/25 06:00 [medline]
AID - virtualmentor.2012.14.2.coet1-1202 [pii]
AID - 10.1001/virtualmentor.2012.14.2.coet1-1202 [doi]
PST - epublish
SO  - Virtual Mentor. 2012 Feb 1;14(2):118-20. doi:
      10.1001/virtualmentor.2012.14.2.coet1-1202.


PMID- 23116919
OWN - NLM
STAT- MEDLINE
DCOM- 20130502
LR  - 20130919
IS  - 1937-7010 (Electronic)
IS  - 1937-7010 (Linking)
VI  - 14
IP  - 1
DP  - 2012 Jan 1
TI  - An ethical take on the "stress vaccine".
PG  - 60-7
LID - 10.1001/virtualmentor.2012.14.1.oped2-1201 [doi]
LID - virtualmentor.2012.14.1.oped2-1201 [pii]
FAU - Ladd, Jennifer M
AU  - Ladd JM
AD  - Stanford University School of Medicine, California, USA.
FAU - Ungar, Leo D J
AU  - Ungar LD
LA  - eng
PT  - Journal Article
DEP - 20120101
PL  - United States
TA  - Virtual Mentor
JT  - The virtual mentor : VM
JID - 101141858
RN  - 0 (Glucocorticoids)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Vaccines, DNA)
RN  - 0 (Vaccines, Synthetic)
SB  - IM
MH  - Brain/drug effects/physiopathology
MH  - Chronic Disease/*prevention & control/psychology
MH  - Ethical Theory
MH  - *Ethics, Medical
MH  - Glucocorticoids/*antagonists & inhibitors/physiology
MH  - Humans
MH  - Mass Vaccination/*ethics
MH  - Moral Obligations
MH  - Neuroprotective Agents/*administration & dosage
MH  - Patient Acceptance of Health Care
MH  - Philosophy, Medical
MH  - Stress, Psychological/*complications/physiopathology/psychology
MH  - United States
MH  - Vaccines, DNA/administration & dosage
MH  - Vaccines, Synthetic/administration & dosage
EDAT- 2012/11/03 06:00
MHDA- 2013/05/03 06:00
CRDT- 2012/11/03 06:00
PHST- 2012/11/03 06:00 [entrez]
PHST- 2012/11/03 06:00 [pubmed]
PHST- 2013/05/03 06:00 [medline]
AID - virtualmentor.2012.14.1.oped2-1201 [pii]
AID - 10.1001/virtualmentor.2012.14.1.oped2-1201 [doi]
PST - epublish
SO  - Virtual Mentor. 2012 Jan 1;14(1):60-7. doi:
      10.1001/virtualmentor.2012.14.1.oped2-1201.


PMID- 23116722
OWN - NLM
STAT- MEDLINE
DCOM- 20130805
LR  - 20211021
IS  - 1878-0326 (Electronic)
IS  - 1872-4973 (Linking)
VI  - 7
IP  - 2
DP  - 2013 Feb
TI  - Incidental findings in the use of DNA to identify human remains: an ethical
      assessment.
PG  - 221-9
LID - 10.1016/j.fsigen.2012.10.002 [doi]
LID - S1872-4973(12)00226-8 [pii]
AB  - DNA analysis is increasingly used to identify the remains of victims of conflicts
      and disasters. This is especially true in cases where remains are badly damaged
      and fragmented, or where antemortem records are unavailable. Incidental findings 
      (IFs)-that is, genetics-related information for which investigators were not
      looking-may result from these identification efforts employing DNA analysis.
      Because of the critical role played by family members of the missing in
      identification efforts, as well as the familial nature of DNA, identification
      initiatives employing DNA analysis are particularly prone to reveal IFs about
      familial relationships, such as misattributed paternity or false beliefs about
      sibling relationships. Despite forensic scientists' widespread awareness of the
      possibility of generating IFs, to date there has been relatively little explicit 
      guidance about their management. This paper fills that gap. It offers substantive
      guidance about the ethical management of IFs in this context. To ensure that the 
      analysis addresses actual needs and practices in the field, one author (JDA)
      conducted semi-structured interviews with key informants from six regionally
      diverse organizations involved in post-conflict or post-disaster identification
      efforts. The paper first describes how methods of DNA analysis give rise to IFs. 
      Next, it explains the importance of developing an ethically justified general
      policy for managing IFs and discusses features of DNA identification efforts that
      are relevant to such a policy. Then it presents an argument in support of a
      general policy of nondisclosure-specifically, that considerations of fair access 
      to the individual and social benefits of identification efforts, and the concern 
      to minimize and fairly distribute the risks of participation, support a policy of
      nondisclosure. It concludes by considering some implications of this argument for
      the choice among scientific practices involved in using DNA analysis to identify 
      human remains, as well as for managing non-genetic incidental findings.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Parker, Lisa S
AU  - Parker LS
AD  - Center for Bioethics and Health Law, University of Pittsburgh, Pittsburgh, PA
      15213, United States. lisap@pitt.edu
FAU - London, Alex John
AU  - London AJ
FAU - Aronson, Jay D
AU  - Aronson JD
LA  - eng
GR  - R01 HG005702/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20121030
PL  - Netherlands
TA  - Forensic Sci Int Genet
JT  - Forensic science international. Genetics
JID - 101317016
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - DNA/*genetics
MH  - *Ethics
MH  - Forensic Anthropology/*methods
MH  - Humans
MH  - *Incidental Findings
PMC - PMC3581719
MID - NIHMS419718
EDAT- 2012/11/03 06:00
MHDA- 2013/08/06 06:00
CRDT- 2012/11/03 06:00
PHST- 2012/08/02 00:00 [received]
PHST- 2012/10/02 00:00 [revised]
PHST- 2012/10/05 00:00 [accepted]
PHST- 2012/11/03 06:00 [entrez]
PHST- 2012/11/03 06:00 [pubmed]
PHST- 2013/08/06 06:00 [medline]
AID - S1872-4973(12)00226-8 [pii]
AID - 10.1016/j.fsigen.2012.10.002 [doi]
PST - ppublish
SO  - Forensic Sci Int Genet. 2013 Feb;7(2):221-9. doi: 10.1016/j.fsigen.2012.10.002.
      Epub 2012 Oct 30.


PMID- 23116717
OWN - NLM
STAT- MEDLINE
DCOM- 20130826
LR  - 20220409
IS  - 1532-1932 (Electronic)
IS  - 1521-6934 (Linking)
VI  - 27
IP  - 2
DP  - 2013 Apr
TI  - Caesarean section on maternal request for non-medical reasons: putting the UK
      National Institute of Health and Clinical Excellence guidelines in perspective.
PG  - 165-77
LID - 10.1016/j.bpobgyn.2012.09.006 [doi]
LID - S1521-6934(12)00159-9 [pii]
AB  - The past decade has seen an unprecedented rise in the demand for caesarean
      sections on maternal request (CSMR), in the absence of any medical or obstetric
      indication. Much of this rise is the result of the perceived myth of safety of
      caesarean sections and the changing attitudes of society and the medical
      profession to childbirth. The debate on the medical, ethical and cost
      implications of rising rates of caesarean section on maternal request have
      prompted the issuing of numerous guidelines over the past few years, including
      one by the National Institute of Health and Clinical Excellence (NICE) in the UK.
      All these guidelines are uniformly less critical of CSMR than guidelines issued
      even a decade ago, and suggest valid management strategies. In this chapter, I
      explore the reasons behind the increase in CSMR and review the current published 
      research, including the risks, benefits, controversies, cost and ethics
      surrounding CSMR. I then discuss various guidelines, putting the NICE guidelines 
      in perspective.
CI  - Copyright (c) 2012. Published by Elsevier Ltd.
FAU - D'Souza, Rohan
AU  - D'Souza R
AD  - Division of Maternal and Fetal Medicine, Department of Obstetrics and
      Gynaecology, Mount Sinai Hospital, Toronto, Canada M5G 1X5.
      rd'souza@mtsinai.on.ca
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121030
PL  - Netherlands
TA  - Best Pract Res Clin Obstet Gynaecol
JT  - Best practice & research. Clinical obstetrics & gynaecology
JID - 101121582
SB  - IM
MH  - *Cesarean Section/adverse effects/economics/ethics/standards
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Newborn, Diseases/etiology/prevention & control
MH  - *Patient Preference
MH  - Pelvic Floor Disorders/etiology/prevention & control
MH  - Physician-Patient Relations
MH  - Postoperative Complications
MH  - Practice Guidelines as Topic
MH  - Pregnancy
MH  - Pregnancy Complications/etiology
MH  - Risk Assessment
MH  - Socioeconomic Factors
MH  - United Kingdom
EDAT- 2012/11/03 06:00
MHDA- 2013/08/27 06:00
CRDT- 2012/11/03 06:00
PHST- 2012/08/19 00:00 [received]
PHST- 2012/09/03 00:00 [revised]
PHST- 2012/09/24 00:00 [accepted]
PHST- 2012/11/03 06:00 [entrez]
PHST- 2012/11/03 06:00 [pubmed]
PHST- 2013/08/27 06:00 [medline]
AID - S1521-6934(12)00159-9 [pii]
AID - 10.1016/j.bpobgyn.2012.09.006 [doi]
PST - ppublish
SO  - Best Pract Res Clin Obstet Gynaecol. 2013 Apr;27(2):165-77. doi:
      10.1016/j.bpobgyn.2012.09.006. Epub 2012 Oct 30.


PMID- 23116681
OWN - NLM
STAT- MEDLINE
DCOM- 20130626
LR  - 20220409
IS  - 1873-491X (Electronic)
IS  - 0020-7489 (Linking)
VI  - 50
IP  - 2
DP  - 2013 Feb
TI  - The impact of the work environment of nurses on patient safety outcomes: a
      multi-level modelling approach.
PG  - 253-63
LID - 10.1016/j.ijnurstu.2012.08.020 [doi]
LID - S0020-7489(12)00302-1 [pii]
AB  - BACKGROUND: Patient safety is a priority for health services in all countries.
      The importance of the nurse's role in patient safety has been established.
      Effective nurse staffing levels, nurse education levels, and a positive work
      environment for nurses are factors which are known to impact on patient safety
      outcomes. OBJECTIVES: This study sought to explore the relationship between the
      ward environment in which nurses practice and specific patient safety outcomes,
      using ward level variables as well as nurse level variables. The outcomes were
      nurse-reported patient safety levels in the wards in which they work, and numbers
      of formal adverse events reports submitted by nurses in the last year. DESIGN:
      This cross-sectional quantitative study was carried out within a European FP7
      project: Nurse Forecasting: Human Resources Planning in Nursing (RN4CAST)
      project. SETTINGS: 108 general medical and surgical wards in 30 hospitals
      throughout Ireland. PARTICIPANTS: All nurses in direct patient care in the study 
      wards were invited to participate. Data from 1397 of these nurses were used in
      this analysis. METHODS: A nurse survey was carried out using a questionnaire
      incorporating the Practice Environment Scale of the Nursing Work Index (PES-NWI).
      Ethical approval was obtained from the authors' institution and all ethics
      committees representing the 30 study hospitals. Multilevel modelling was carried 
      out to examine the impact of ward level factors on patient safety. These included
      proportions of nurses on the ward educated to degree level, and aggregated
      ward-level mean for PES-NWI scores. RESULTS: The study results support other
      research findings indicating that a positive practice environment enhances
      patient safety outcomes. Specifically at ward level, factors such as the ward
      practice environment and the proportion of nurses with degrees were found to
      significantly impact safety outcomes. The models developed for this study
      predicted 76% and 51% of the between-ward variance of these outcomes. The results
      can be used to enhance patient safety within hospitals by demonstrating factors
      at ward-level which enable nurses to effectively carry out this aspect of their
      role. CONCLUSIONS: The importance of ward-level nurse factors such as nurse
      education level and the work environment should be recognised and manipulated as 
      important influences on patient safety.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Kirwan, Marcia
AU  - Kirwan M
AD  - Dublin City University, Ireland.
FAU - Matthews, Anne
AU  - Matthews A
FAU - Scott, P Anne
AU  - Scott PA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121030
PL  - England
TA  - Int J Nurs Stud
JT  - International journal of nursing studies
JID - 0400675
SB  - IM
MH  - Burnout, Professional
MH  - Cross-Sectional Studies
MH  - Humans
MH  - Ireland
MH  - *Models, Organizational
MH  - *Nursing Staff, Hospital
MH  - Organizational Culture
MH  - *Patient Safety
MH  - *Workplace
EDAT- 2012/11/03 06:00
MHDA- 2013/06/28 06:00
CRDT- 2012/11/03 06:00
PHST- 2012/02/29 00:00 [received]
PHST- 2012/07/18 00:00 [revised]
PHST- 2012/08/30 00:00 [accepted]
PHST- 2012/11/03 06:00 [entrez]
PHST- 2012/11/03 06:00 [pubmed]
PHST- 2013/06/28 06:00 [medline]
AID - S0020-7489(12)00302-1 [pii]
AID - 10.1016/j.ijnurstu.2012.08.020 [doi]
PST - ppublish
SO  - Int J Nurs Stud. 2013 Feb;50(2):253-63. doi: 10.1016/j.ijnurstu.2012.08.020. Epub
      2012 Oct 30.


PMID- 23115874
OWN - NLM
STAT- MEDLINE
DCOM- 20121127
LR  - 20190923
IS  - 1547-1896 (Print)
IS  - 0893-7400 (Linking)
VI  - 25
IP  - 10
DP  - 2012 Oct
TI  - Fast-track areas in the emergency department: are they ethical?
PG  - 57-8
FAU - Bergman, Brett
AU  - Bergman B
AD  - Loma Linda University, Loma Linda, California, USA.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - JAAPA
JT  - JAAPA : official journal of the American Academy of Physician Assistants
JID - 9513102
MH  - Beneficence
MH  - Crowding
MH  - Emergency Service, Hospital/*organization & administration
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - *Physician Assistants
MH  - Professional Role
MH  - Triage/*ethics
EDAT- 2012/11/03 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/11/03 06:00
PHST- 2012/11/03 06:00 [entrez]
PHST- 2012/11/03 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1097/01720610-201210000-00015 [doi]
PST - ppublish
SO  - JAAPA. 2012 Oct;25(10):57-8. doi: 10.1097/01720610-201210000-00015.


PMID- 23115828
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20161021
IS  - 1134-7198 (Print)
IS  - 1134-7198 (Linking)
IP  - 36
DP  - 2012 Jan-Jun
TI  - Ethical aspects of informed consent for the collection, preservation and use of
      cells and tissues in biological banks for research purposes.
PG  - 173-205
AB  - This article explores the current and proposed requirements for informed consent 
      for research with biological samples. The establishment of biobanks and the
      capabilities of collecting, storing, and using cells and tissues for research
      purposes have noticeably grown. With new abilities come new challenges to ethical
      questions of consent, specifically concerning genetic information, and
      unanticipated usage. This paper summarizes these issues in the context of levels 
      of informed consent, subject risk, individual vs. societal benefits, anonymity,
      legal consensus.
FAU - Petrini, Carlo
AU  - Petrini C
AD  - Italian National Institute of Health, Rome, Italy. carlo.petrini@iss.it
LA  - eng
PT  - Journal Article
PL  - Spain
TA  - Rev Derecho Genoma Hum
JT  - Revista de derecho y genoma humano = Law and the human genome review
JID - 101558644
SB  - IM
MH  - Cells
MH  - *Ethics, Research
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Tissue Banks/*ethics
EDAT- 2012/11/03 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/11/03 06:00
PHST- 2012/11/03 06:00 [entrez]
PHST- 2012/11/03 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
PST - ppublish
SO  - Rev Derecho Genoma Hum. 2012 Jan-Jun;(36):173-205.


PMID- 23115823
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20161021
IS  - 1134-7198 (Print)
IS  - 1134-7198 (Linking)
IP  - 36
DP  - 2012 Jan-Jun
TI  - [Triploid cloned human embryos: ethical, social, and legal aspects].
PG  - 25-63
AB  - This work attempts to place the experiment within the scientific and social
      framework of pluripotent-stem-cell research and offer reflections of an ethical
      and (to a lesser extent) legal nature on the results obtained by this research
      group. To these ends, the work is divided into two parts. The first part
      describes the most important aspects of Noggle and Egli's announcement and the
      biotechnological and media context in which it was made. The second part is
      concerned with the bioethical issues raised by the experiment. There are
      basically four issues, which relate to: (1) the nuclear transfer technique, (2)
      the use of human ovules to carry out the experiment, (3) the destruction of human
      blastocysts, and (4) the ethical requirements of scientific publications.
FAU - Bellver Capella, Vicente
AU  - Bellver Capella V
AD  - Universitat de Valencia, Valencia, Espana.
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Embriones humanos clonicos triploides: aspectos eticos, sociales y juridicos.
PL  - Spain
TA  - Rev Derecho Genoma Hum
JT  - Revista de derecho y genoma humano = Law and the human genome review
JID - 101558644
SB  - IM
MH  - Cloning, Organism/*ethics/*legislation & jurisprudence
MH  - *Embryo, Mammalian
MH  - Humans
MH  - Sociology
MH  - Spain
MH  - *Triploidy
EDAT- 2012/11/03 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/11/03 06:00
PHST- 2012/11/03 06:00 [entrez]
PHST- 2012/11/03 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
PST - ppublish
SO  - Rev Derecho Genoma Hum. 2012 Jan-Jun;(36):25-63.


PMID- 23115822
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20161021
IS  - 1134-7198 (Print)
IS  - 1134-7198 (Linking)
IP  - 36
DP  - 2012 Jan-Jun
TI  - [Ethical and legal principles for the activities of bioprospection in relation to
      human beings and the human genome].
PG  - 13-21
AB  - During recent decades, bioprospecting has become an important field of research, 
      which looks for development alternatives, entry into global (environmental)
      markets, and the subsequent obtention of benefits under sustainable development
      principles. However, there is still so much to discuss regarding the social and
      environmental impacts produced by this activity, as well as its main limitations.
      To this end, the Forum/round-table discussion, entitled "Bioprospeccion, Etica y 
      Sociedad" was organised to take place on 28 March 2012 at the National University
      of Colombia. Its main objective was to enrich our knowledge on bioprospecting
      considering the ethical considerations that involve society. The presentation
      given by Professor ROMEO CASABONA, regarding the connection between
      bioprospecting and the human genome deserves special attention and is presented
      below.
FAU - Romeo Casabona, Carlos Maria
AU  - Romeo Casabona CM
AD  - Universidad de Deusto y Universidad del Pais Vasco UPV/EHU, Bilbao, Espana.
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Principios eticos y juridicos para las actividades de bioprospeccion con relacion
      al ser humano y al genoma humano.
PL  - Spain
TA  - Rev Derecho Genoma Hum
JT  - Revista de derecho y genoma humano = Law and the human genome review
JID - 101558644
SB  - IM
MH  - Biomedical Research/*ethics/*legislation & jurisprudence
MH  - Colombia
MH  - *Genome, Human
MH  - Humans
EDAT- 2012/11/03 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/11/03 06:00
PHST- 2012/11/03 06:00 [entrez]
PHST- 2012/11/03 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
PST - ppublish
SO  - Rev Derecho Genoma Hum. 2012 Jan-Jun;(36):13-21.


PMID- 23115719
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121102
LR  - 20211021
IS  - 2074-1812 (Electronic)
IS  - 2074-1804 (Linking)
VI  - 14
IP  - 9
DP  - 2012 Sep
TI  - Lidocaine Cyclodextrin complex Ophthalmic Drop, a New Topical Anesthetic Choice.
PG  - 569-73
AB  - BACKGROUND: Topical anesthesia is a safe and cost-effective method considered as 
      the first-choice in many procedures. Due to the physiological characteristics of 
      eye, most of the local anesthetics cannot efficiently penetrate through the
      conjunctiva deep to tenon. The aim of this pilot study was to find a new form of 
      lidocaine to give a sufficient level of anesthesia. METHODS: Lidocaine
      Cyclodextrin complex ophthalmic drop was produced and its pharmacological
      properties were studied [tested] in standard temperature and pressure. 30
      patients (18 males, 12 females) with the mean age of 30.68+/-8.02 years enrolled 
      in this clinical trial. All the patients were fully informed and signed the
      ethics committee consent forms. The patients were given tetracaine drop as the
      anesthetic: 3 drops separated 2 minute apart 10 min before the intervention. If
      we achieved a sufficient level of anesthesia, the procedure was done after. If
      the patient could not tolerate the procedure, the method was changed to lidocaine
      drop (administered after wash-out period like the first drop).The last option was
      conventional injection method if the patient could not tolerate the procedure
      with the second method either.We used this type of anesthesia for conventional
      procedures such as forced duction test, symblepharon, pterygium, and disport
      injection into extra-ocular muscles. All the procedures were done by one surgeon 
      in a university hospital. We used a 0 to 10 visual analogue scale for pain and
      two 0 to 4 patient and physician satisfaction scales designed for this study.
      RESULTS: The mean pain score was 7.53+/-0.90 in group 1 and 3.03+/-1.83 in group 
      2 (P=0.00). Patient and surgeon satisfaction in group 1 were 1.33+/-0.48 and
      1.40+/-0.56 respectively; while 3.23+/-1.00 and 3.56+/-0.77 for group 2 (P=0.00).
      Tetracaine drop could not induce sufficient anesthesia for none of the patients. 
      Cyclodextrin based lidocaine drop was successful except For two patients for whom
      we changed the anesthesia to Sub-conjunctival injection method. CONCLUSION: Our
      newly manufactured cyclodextrin based lidocaine eye drop could successfully
      induce sufficient anesthesia for 28 of 30 patients. Further studies with larger
      sample sizes are now being designed to find more clinical evidence about this
      method.
FAU - Sabermoghadam Ranjbar, Aa
AU  - Sabermoghadam Ranjbar A
AD  - Ophthalmology research center, Mashhad University of Medical Sciences, Mashhad,
      Iran.
FAU - Rajabi, O
AU  - Rajabi O
FAU - Salari, R
AU  - Salari R
FAU - Ashraf, H
AU  - Ashraf H
LA  - eng
PT  - Journal Article
DEP - 20120930
PL  - Iran
TA  - Iran Red Crescent Med J
JT  - Iranian Red Crescent medical journal
JID - 101319850
PMC - PMC3482329
OTO - NOTNLM
OT  - Cyclodextrin
OT  - Drug Delivery
OT  - Dysport
OT  - Lidocaine
OT  - Ophthalmicdrop
OT  - Pterygium
OT  - Symblepharon
EDAT- 2012/11/02 06:00
MHDA- 2012/11/02 06:01
CRDT- 2012/11/02 06:00
PHST- 2012/02/18 00:00 [received]
PHST- 2012/02/18 00:00 [accepted]
PHST- 2012/11/02 06:00 [entrez]
PHST- 2012/11/02 06:00 [pubmed]
PHST- 2012/11/02 06:01 [medline]
PST - ppublish
SO  - Iran Red Crescent Med J. 2012 Sep;14(9):569-73. Epub 2012 Sep 30.


PMID- 23115359
OWN - NLM
STAT- MEDLINE
DCOM- 20121227
LR  - 20211021
IS  - 0008-5286 (Print)
IS  - 0008-5286 (Linking)
VI  - 53
IP  - 5
DP  - 2012 May
TI  - Veterinary medical ethics: an ethicist's commentary on housing for fur animals
      versus agricultural animals.
PG  - 466-8
FAU - Rollin, Bernard E
AU  - Rollin BE
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Vet J
JT  - The Canadian veterinary journal = La revue veterinaire canadienne
JID - 0004653
SB  - IM
MH  - Agriculture
MH  - Animal Husbandry/*ethics
MH  - *Animal Welfare
MH  - Animals
MH  - Hair
MH  - Housing, Animal/*ethics
MH  - Humans
MH  - Veterinarians/ethics/*psychology
PMC - PMC3327584
EDAT- 2012/11/02 06:00
MHDA- 2012/12/28 06:00
CRDT- 2012/11/02 06:00
PHST- 2012/11/02 06:00 [entrez]
PHST- 2012/11/02 06:00 [pubmed]
PHST- 2012/12/28 06:00 [medline]
PST - ppublish
SO  - Can Vet J. 2012 May;53(5):466-8.


PMID- 23114981
OWN - NLM
STAT- MEDLINE
DCOM- 20131127
LR  - 20211021
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 24
IP  - 4
DP  - 2012 Dec
TI  - The eroding principle of justice in teaching medical professionalism.
PG  - 293-305
LID - 10.1007/s10730-012-9199-4 [doi]
AB  - This article examines the difficulties encountered in teaching professionalism to
      medical students in the current social and political climate where economic
      considerations take top priority in health care decision making. The conflict
      between the commitment to advocate at all times the interests of one's patients
      over one's own interests is discussed. With personal, institutional, tech
      industry, pharmaceutical industry, and third-party payer financial imperatives
      that stand between patients and the delivery of health care, this article
      investigates how medical ethics instructors are to teach professionalism in a
      responsible way that does not avoid dealing with the principle of justice.
FAU - Glenn, Jason E
AU  - Glenn JE
AD  - Institute for the Medical Humanities, University of Texas Medical Branch, 301
      University Blvd., Galveston, TX 77555-1311, USA. jeglenn@utmb.edu
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - *Education, Medical, Undergraduate
MH  - Humans
MH  - Patient Advocacy
MH  - *Professional Competence
MH  - Social Justice/*education
MH  - United States
EDAT- 2012/11/02 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/11/02 06:00
PHST- 2012/11/02 06:00 [entrez]
PHST- 2012/11/02 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1007/s10730-012-9199-4 [doi]
PST - ppublish
SO  - HEC Forum. 2012 Dec;24(4):293-305. doi: 10.1007/s10730-012-9199-4.


PMID- 23114841
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130108
LR  - 20211021
IS  - 1868-310X (Print)
IS  - 1868-310X (Linking)
VI  - 4
IP  - 1
DP  - 2013 Jan
TI  - Conceptions on genetics in a group of college students.
PG  - 115-23
LID - 10.1007/s12687-012-0125-x [doi]
AB  - The purpose of this study was to investigate awareness, beliefs, and opinions on 
      genetics in a group of Brazilian college students from several courses. The study
      used the focus group technique with the participation of 19 students, divided
      into four groups. Also, it used the isotopic reading technique to analyze the
      material. The results were divided in four themes: the basic knowledge of
      genetics, the "new genetics," including molecular biology and testing, genetic
      manipulation, and genetics and the media. The participants showed reasonable
      knowledge on the subject, obtained from various sources, including the printed
      press, the internet, documentaries, and fictional TV shows. Ethical issues were
      discussed comprehensively and the groups showed awareness on the hazards brought 
      by genetic reductionism and the need to have some type of regulation regarding
      genetic manipulation and testing. It is necessary to broaden the debate about the
      progress in genetics because some of them will affect a significant number of
      people. This debate should include the lay public, which has been actively
      participating in decisions involving research and the use of new technologies.
FAU - Correia, Patricia Santana
AU  - Correia PS
AD  - Instituto Nacional de Saude da Mulher, da Crianca e do Adolescente Fernandes
      Figueira-FIOCRUZ, Av Rui Barbosa, 716, Rio de Janeiro, RJ, Brazil, 22250020,
      correia.pat@gmail.com.
FAU - Vitiello, Pedro
AU  - Vitiello P
FAU - Cardoso, Maria Helena Cabral de Almeida
AU  - Cardoso MH
FAU - Horovitz, Dafne Dain Gandelman
AU  - Horovitz DD
LA  - eng
PT  - Journal Article
DEP - 20121101
PL  - Germany
TA  - J Community Genet
JT  - Journal of community genetics
JID - 101551501
PMC - PMC3537979
EDAT- 2012/11/02 06:00
MHDA- 2012/11/02 06:01
CRDT- 2012/11/02 06:00
PHST- 2012/04/03 00:00 [received]
PHST- 2012/10/15 00:00 [accepted]
PHST- 2012/11/02 06:00 [entrez]
PHST- 2012/11/02 06:00 [pubmed]
PHST- 2012/11/02 06:01 [medline]
AID - 10.1007/s12687-012-0125-x [doi]
PST - ppublish
SO  - J Community Genet. 2013 Jan;4(1):115-23. doi: 10.1007/s12687-012-0125-x. Epub
      2012 Nov 1.


PMID- 23114806
OWN - NLM
STAT- MEDLINE
DCOM- 20130124
LR  - 20121101
IS  - 0353-5053 (Print)
IS  - 0353-5053 (Linking)
VI  - 24 Suppl 3
DP  - 2012 Oct
TI  - Impact of destruction of classic moral principles on ethical questions in
      psychiatry.
PG  - S298-302
AB  - Society's treatment of psychiatric patients was always a reflection of social
      development and social awareness, as well as of ethical principles dominating a
      certain time period in that society. Over the last two and a half millennia,
      during which principles of Hippocratic ethics applied, attitudes towards
      psychiatric patients, from an ethical and practical standpoint, were and still
      are controversial to say the least. During this period thousands of people with
      mental disorders were abused, tortured, or killed, all of this in accordance to
      the existing ethical and legislative norms (Malleus Maleficarum, eugenic laws of 
      totalitarian regimes...). In the last forty years many international
      organizations and associations brought forth a number of resolutions and
      declarations warning of the position and of the rights of psychiatric patients
      and giving instructions on the humane, that is to say ethical, treatment of this 
      category of patients. In almost all the western countries laws are passed to
      protect the rights of people with mental disorders. Thanks to this and maybe even
      more to the development of psychiatry as a medical and scientific profession, the
      position of those with mental disorders is improving. However, at the same time
      over the last 40 years we are witnesses to the destruction of the classic moral
      principles and the establishment of certain "new" ethics which put psychiatric
      patients at a disadvantage, only in a more subtle way then before. This is why it
      is important to reexamine many of the ethical questions in psychiatry in the
      context of present ethical controversy.
FAU - Jukic, Vlado
AU  - Jukic V
AD  - University Psychiatric Hospital Vrapce, Bolnicka c. 32, Zagreb, Croatia.
      vlado.jukic@bolnica-vrapce.hr
LA  - eng
PT  - Journal Article
PL  - Croatia
TA  - Psychiatr Danub
JT  - Psychiatria Danubina
JID - 9424753
SB  - IM
MH  - Humans
MH  - Mental Disorders/classification/*therapy
MH  - Physician-Patient Relations/*ethics
MH  - Psychiatry/classification/*ethics
EDAT- 2012/11/02 06:00
MHDA- 2013/01/25 06:00
CRDT- 2012/11/02 06:00
PHST- 2012/11/02 06:00 [entrez]
PHST- 2012/11/02 06:00 [pubmed]
PHST- 2013/01/25 06:00 [medline]
PST - ppublish
SO  - Psychiatr Danub. 2012 Oct;24 Suppl 3:S298-302.


PMID- 23114805
OWN - NLM
STAT- MEDLINE
DCOM- 20130124
LR  - 20151026
IS  - 0353-5053 (Print)
IS  - 0353-5053 (Linking)
VI  - 24 Suppl 3
DP  - 2012 Oct
TI  - Recovery--reshaping our clinical and scientific responsibilities.
PG  - S291-7
AB  - CONTEXT: Advocacy for Recovery has been joined by research offering new
      perspectives on mental health policy, treatment, rehabilitation and
      anti-discrimination efforts. OBJECTIVES: Chances and challenges of a Recovery
      model for the mental health field will be presented and discussed. KEY MESSAGES: 
      Recovery is currently widely endorsed as a guiding principle of mental health
      policy. New rules for services, e.g. user involvement and person-centred care, as
      well as new tools for clinical collaborations, e.g. shared decision making and
      psychiatric advance directives, are being complemented by new proposals regarding
      more ethically consistent anti-discrimination and involuntary treatment
      legislation as well as participatory approaches to evidence-based medicine and
      policy. Recovery advocacy has been joined by research on recovery and resilience 
      resulting in new data on the long-term perspectives of people experiencing common
      as well as severe mental health problems. Definitions of remission and recovery
      as well as the concept of chronicity are under debate. Research questions
      regarding recovery as a process as well as an outcome warrant scientific efforts 
      enabling the integration of different perspectives as well as different
      methodologies. CONCLUSIONS: Consequences and challenges of the Recovery model
      need to be tackled from different perspectives by clinicians, researchers, policy
      makers and - essentially - users and carers and their representatives in order to
      be fully explored and brought to life.
FAU - Amering, Michaela
AU  - Amering M
AD  - Medical University of Vienna, Department of Psychiatry and Psychotherapy,
      Spitalgasse 23, 1090 Vienna, Austria. michaela.amering@meduniwien.ac.at
LA  - eng
PT  - Journal Article
PL  - Croatia
TA  - Psychiatr Danub
JT  - Psychiatria Danubina
JID - 9424753
SB  - IM
MH  - Evidence-Based Medicine/*standards
MH  - Humans
MH  - Mental Health Services/organization & administration/*standards/trends
EDAT- 2012/11/02 06:00
MHDA- 2013/01/25 06:00
CRDT- 2012/11/02 06:00
PHST- 2012/11/02 06:00 [entrez]
PHST- 2012/11/02 06:00 [pubmed]
PHST- 2013/01/25 06:00 [medline]
PST - ppublish
SO  - Psychiatr Danub. 2012 Oct;24 Suppl 3:S291-7.


PMID- 23114453
OWN - NLM
STAT- MEDLINE
DCOM- 20131112
LR  - 20160707
IS  - 1437-1588 (Electronic)
IS  - 1436-9990 (Linking)
VI  - 55
IP  - 11-12
DP  - 2012 Nov
TI  - [Progress report of the central ethics committee for stem cell research].
PG  - 1534-40
LID - 10.1007/s00103-012-1572-6 [doi]
CN  - Zentrale Ethik-Kommission fur Stammzellenforschung
LA  - ger
PT  - Journal Article
TT  - Tatigkeitsbericht der Zentralen Ethik-Kommission fur Stammzellenforschung (ZES).
PL  - Germany
TA  - Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
JT  - Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
JID - 101181368
SB  - IM
MH  - Cooperative Behavior
MH  - *Ethics Committees/legislation & jurisprudence
MH  - Germany
MH  - Humans
MH  - Interdisciplinary Communication
MH  - *Research Report/legislation & jurisprudence
MH  - Stem Cell Research/*ethics/legislation & jurisprudence
EDAT- 2012/11/02 06:00
MHDA- 2013/11/13 06:00
CRDT- 2012/11/02 06:00
PHST- 2012/11/02 06:00 [entrez]
PHST- 2012/11/02 06:00 [pubmed]
PHST- 2013/11/13 06:00 [medline]
AID - 10.1007/s00103-012-1572-6 [doi]
PST - ppublish
SO  - Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2012
      Nov;55(11-12):1534-40. doi: 10.1007/s00103-012-1572-6.


PMID- 23114230
OWN - NLM
STAT- MEDLINE
DCOM- 20130528
LR  - 20220331
IS  - 1477-7819 (Electronic)
IS  - 1477-7819 (Linking)
VI  - 10
DP  - 2012 Nov 1
TI  - Primary pulmonary mucoepidermoid carcinoma: an analysis of 21 cases.
PG  - 232
LID - 10.1186/1477-7819-10-232 [doi]
AB  - BACKGROUND: The optimal treatment for pulmonary mucoepidermoid carcinoma (MEC), a
      rare type of tumor, has not been established yet. This study analyzed the
      survival of pulmonary MEC patients and attempted to find clues for optimal
      treatment. METHODS: A total of 21 patients with pulmonary MEC from November 2004 
      to January 2011 were included in the investigation. Immunohistochemistry,
      epidermal growth factor receptor (EGFR) mutation, and survival were
      retrospectively studied. RESULTS: Among the 21 pulmonary MEC patients, 17 were
      diagnosed with low-grade malignancy and 4 with high-grade malignancy through
      pathological examination. The prognosis was found to be poor in the presence of
      lymph nodes. The expression rates of EGFR and HER2 were 28.6% and 0%,
      respectively, which correlated with neither grade nor prognosis. The mutation
      rate of EGFR was 0. Log-rank test results indicated that age, grade, lymph node
      metastasis, and tumor-node-metastasis stage were prognostic factors. CONCLUSION: 
      Age, grade, lymph node metastasis and tumor-node-metastasis stage correlate with 
      the survival of pulmonary MEC patients. TRIAL REGISTRATION: This study was
      approved and registered by the Ethics Committee of Zhongshan Hospital. Written
      informed consent was obtained from all participants prior to treatment.
FAU - Xi, Jun-jie
AU  - Xi JJ
AD  - Division of Thoracic Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin
      Road, Shanghai, 200032, China.
FAU - Jiang, Wei
AU  - Jiang W
FAU - Lu, Shao-hua
AU  - Lu SH
FAU - Zhang, Chun-yan
AU  - Zhang CY
FAU - Fan, Hong
AU  - Fan H
FAU - Wang, Qun
AU  - Wang Q
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20121101
PL  - England
TA  - World J Surg Oncol
JT  - World journal of surgical oncology
JID - 101170544
RN  - 0 (DNA, Neoplasm)
RN  - EC 2.7.10.1 (ErbB Receptors)
SB  - IM
MH  - Adult
MH  - Carcinoma, Mucoepidermoid/*diagnosis/genetics/mortality
MH  - China/epidemiology
MH  - DNA Mutational Analysis
MH  - DNA, Neoplasm/*genetics
MH  - ErbB Receptors/*genetics/metabolism
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Immunohistochemistry
MH  - Lung Neoplasms/*diagnosis/genetics/mortality
MH  - Male
MH  - *Mutation
MH  - Prognosis
MH  - Retrospective Studies
MH  - Survival Rate/trends
PMC - PMC3526401
EDAT- 2012/11/02 06:00
MHDA- 2013/05/29 06:00
CRDT- 2012/11/02 06:00
PHST- 2012/07/31 00:00 [received]
PHST- 2012/10/15 00:00 [accepted]
PHST- 2012/11/02 06:00 [entrez]
PHST- 2012/11/02 06:00 [pubmed]
PHST- 2013/05/29 06:00 [medline]
AID - 1477-7819-10-232 [pii]
AID - 10.1186/1477-7819-10-232 [doi]
PST - epublish
SO  - World J Surg Oncol. 2012 Nov 1;10:232. doi: 10.1186/1477-7819-10-232.


PMID- 23114014
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140812
LR  - 20211021
IS  - 1756-994X (Print)
IS  - 1756-994X (Linking)
VI  - 4
IP  - 10
DP  - 2012
TI  - Beyond the genome and into the clinic.
PG  - 78
LID - 10.1186/gm379 [doi]
AB  - A report of BioMed Central's third annual Beyond the Genome conference, held at
      Harvard Medical School, Boston, September 27-29, 2012.
FAU - Segal, David J
AU  - Segal DJ
AD  - Genome Center and Department of Biochemistry and Molecular Medicine, University
      of California, 451 Health Sciences Drive, Davis, CA 95616, USA.
LA  - eng
PT  - Journal Article
DEP - 20121030
PL  - England
TA  - Genome Med
JT  - Genome medicine
JID - 101475844
PMC - PMC3580447
OTO - NOTNLM
OT  - Bioinformatics
OT  - cancer
OT  - clinical diagnostics
OT  - epigenomics
OT  - ethics
OT  - human disease
OT  - human genomics
OT  - next-generation sequencing
OT  - pre-clinical models
OT  - rare variants
EDAT- 2012/11/02 06:00
MHDA- 2012/11/02 06:01
CRDT- 2012/11/02 06:00
PHST- 2012/11/02 06:00 [entrez]
PHST- 2012/11/02 06:00 [pubmed]
PHST- 2012/11/02 06:01 [medline]
AID - 10.1186/gm379 [doi]
AID - gm379 [pii]
PST - epublish
SO  - Genome Med. 2012 Oct 30;4(10):78. doi: 10.1186/gm379. eCollection 2012.


PMID- 23113873
OWN - NLM
STAT- MEDLINE
DCOM- 20140307
LR  - 20191210
IS  - 1473-0782 (Electronic)
IS  - 1362-5187 (Linking)
VI  - 17
IP  - 6
DP  - 2012 Dec
TI  - Preparing for PrEP.
PG  - 482-6
LID - 10.3109/13625187.2012.723225 [doi]
AB  - Recent studies have shown that in selected conditions antiretroviral drugs can be
      used to protect HIV seronegative persons from becoming infected, when exposed to 
      the risk of sexual HIV transmission. This concept of 'pre-exposure prophylaxis'
      or 'PrEP' has raised many questions that concern cost, safety and ethical issues.
      In this article, different aspects of PrEP are analysed with a view to trying to 
      answer the question whether today's society is already prepared to accept PrEP as
      one of the tools to prevent transmission of HIV by high-risk sexual contacts.
FAU - Lacor, Patrick
AU  - Lacor P
AD  - Department of Internal Medicine, Infectious Diseases Unit, Universitair
      Ziekenhuis Brussel, Brussels, Belgium. patrick.lacor@uzbrussel.be
LA  - eng
PT  - Journal Article
DEP - 20121031
PL  - England
TA  - Eur J Contracept Reprod Health Care
JT  - The European journal of contraception & reproductive health care : the official
      journal of the European Society of Contraception
JID - 9712127
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - Anti-HIV Agents/*therapeutic use
MH  - Centers for Disease Control and Prevention, U.S.
MH  - Cost-Benefit Analysis
MH  - Environmental Exposure
MH  - HIV Infections/drug therapy/*prevention & control/transmission
MH  - HIV Seronegativity
MH  - Humans
MH  - *Premedication/adverse effects/ethics
MH  - Risk Factors
MH  - Risk Management
MH  - United States
EDAT- 2012/11/02 06:00
MHDA- 2014/03/08 06:00
CRDT- 2012/11/02 06:00
PHST- 2012/11/02 06:00 [entrez]
PHST- 2012/11/02 06:00 [pubmed]
PHST- 2014/03/08 06:00 [medline]
AID - 10.3109/13625187.2012.723225 [doi]
PST - ppublish
SO  - Eur J Contracept Reprod Health Care. 2012 Dec;17(6):482-6. doi:
      10.3109/13625187.2012.723225. Epub 2012 Oct 31.


PMID- 23113692
OWN - NLM
STAT- MEDLINE
DCOM- 20140430
LR  - 20131029
IS  - 1471-6712 (Electronic)
IS  - 0283-9318 (Linking)
VI  - 27
IP  - 4
DP  - 2013 Dec
TI  - Faced with a dilemma: Danish midwives' experiences with and attitudes towards
      late termination of pregnancy.
PG  - 913-20
LID - 10.1111/scs.12004 [doi]
AB  - BACKGROUND: The introduction of prenatal screening for all pregnant women in
      Denmark in 2004 has lead to an increase in the number of late terminations of
      pregnancy after the 12th week of pregnancy. Midwives' experiences with late
      termination of pregnancy (TOP) are still poorly described in the scientific
      literature. AIM: To explore Danish midwives' experiences with and attitudes
      towards late TOP. Focus was on how midwives perceive their own role in late TOP, 
      and how their professional identity is influenced by working with late TOP in a
      time where prenatal screening is rapidly developing. METHOD: A qualitative study 
      consisting of ten individual interviews with Danish midwives, all of whom had
      taken part in late TOP. RESULTS: Current practice of late TOP resembles the
      practice of normal deliveries and is influenced by a growing personalisation of
      the aborted foetus. The midwives strongly supported women's legal right to choose
      TOP and considerations about the foetus' right to live were suppressed. Midwives 
      experienced a dilemma when faced with aborted foetuses that looked like newborns 
      and when aborted foetuses showed signs of life after a termination. Furthermore, 
      they were critical of how physicians counsel women/couples after prenatal
      diagnosis. CONCLUSIONS: The midwives' practice in relation to late TOP was
      characterised by an acknowledgement of the growing ethical status of the foetus
      and the emotional reactions of the women/couples going through late TOP. Other
      professions as well as structural factors at the hospital highly influenced the
      midwives' ability to organize their work with late terminations. There is a need 
      for more thorough investigation of how to secure the best possible working
      conditions for midwives, and how to optimise the care for women/couples going
      through late TOP.
CI  - (c) 2012 The Authors Scandinavian Journal of Caring Sciences (c) 2012 Nordic
      College of Caring Science.
FAU - Christensen, Anne Vinggaard
AU  - Christensen AV
AD  - Unit of Women and Gender Research in Medicine, Section of General Practice and
      The Research Unit in General Practice, Department of Public Health, University of
      Copenhagen, Copenhagen, Denmark.
FAU - Christiansen, Anne Hjollund
AU  - Christiansen AH
FAU - Petersson, Birgit
AU  - Petersson B
LA  - eng
PT  - Journal Article
DEP - 20121031
PL  - Sweden
TA  - Scand J Caring Sci
JT  - Scandinavian journal of caring sciences
JID - 8804206
MH  - *Abortion, Legal
MH  - *Attitude of Health Personnel
MH  - Denmark
MH  - Female
MH  - Humans
MH  - Nurse Midwives/*psychology
MH  - Pregnancy
OTO - NOTNLM
OT  - attitudes
OT  - care
OT  - ethics
OT  - midwifery
EDAT- 2012/11/02 06:00
MHDA- 2014/05/03 06:00
CRDT- 2012/11/02 06:00
PHST- 2012/06/15 00:00 [received]
PHST- 2012/09/18 00:00 [accepted]
PHST- 2012/11/02 06:00 [entrez]
PHST- 2012/11/02 06:00 [pubmed]
PHST- 2014/05/03 06:00 [medline]
AID - 10.1111/scs.12004 [doi]
PST - ppublish
SO  - Scand J Caring Sci. 2013 Dec;27(4):913-20. doi: 10.1111/scs.12004. Epub 2012 Oct 
      31.


PMID- 23113159
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121101
LR  - 20220317
IS  - 2251-6085 (Print)
IS  - 2251-6085 (Linking)
VI  - 41
IP  - 4
DP  - 2012
TI  - Public health ethics related training for public health workforce: an emerging
      need in the United States.
PG  - 1-8
AB  - BACKGROUND: Ethics is a discipline, which primarily deals with what is moral and 
      immoral behavior. Public Health Ethics is translation of ethical theories and
      concepts into practice to address complex multidimensional public health
      problems. The primary purpose of this paper was to conduct a narrative literature
      review-addressing role of ethics in developing curriculum in programs and schools
      of public health, ethics-related instruction in schools and programs of public
      health and the role of ethics in developing a competent public health workforce. 
      METHODS: An open search of various health databases including Google scholar and 
      Ebscohost yielded 15 articles related to use of ethics in public health practice 
      or public health training and the salient features were reported. RESULTS:
      Results indicated a variable amount of ethics' related training in schools and
      programs of public health along with public health practitioner training across
      the nation. Bioethics, medical ethics and public health ethics were found to be
      subspecialties' needing separate ethical frameworks to guide decision making.
      CONCLUSIONS: Ethics based curricular and non-curricular training for emerging
      public health professionals from schools and programs of public health in the
      United States is extremely essential. In the current age of public health
      challenges faced in the United States and globally, to have an ethically
      untrained public health force is arguably, immoral and unethical and jeopardizes 
      population health. There is an urgent need to develop innovative ethic based
      curriculums in academia as well as finding effective means to translate these
      curricular competencies into public health practice.
FAU - Kanekar, A
AU  - Kanekar A
AD  - Dept. of Health Sciences, Fribourgh Hall, University of Arkansas, Little Rock,
      72204, USA.
FAU - Bitto, A
AU  - Bitto A
LA  - eng
PT  - Journal Article
DEP - 20120430
PL  - Iran
TA  - Iran J Public Health
JT  - Iranian journal of public health
JID - 7505531
PMC - PMC3481609
OTO - NOTNLM
OT  - Competencies
OT  - Ethics
OT  - Public health Ethics
OT  - Public health workforce
OT  - USA
EDAT- 2012/11/01 06:00
MHDA- 2012/11/01 06:01
CRDT- 2012/11/01 06:00
PHST- 2011/10/14 00:00 [received]
PHST- 2012/02/12 00:00 [accepted]
PHST- 2012/11/01 06:00 [entrez]
PHST- 2012/11/01 06:00 [pubmed]
PHST- 2012/11/01 06:01 [medline]
PST - ppublish
SO  - Iran J Public Health. 2012;41(4):1-8. Epub 2012 Apr 30.


PMID- 23112556
OWN - NLM
STAT- MEDLINE
DCOM- 20140422
LR  - 20220311
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Linking)
VI  - 18
IP  - 39
DP  - 2012 Oct 21
TI  - Comparison between different reconstruction routes in esophageal squamous cell
      carcinoma.
PG  - 5616-21
LID - 10.3748/wjg.v18.i39.5616 [doi]
AB  - AIM: To compare postoperative complications and prognosis of esophageal squamous 
      cell carcinoma patients treated with different routes of reconstruction. METHODS:
      After obtaining approval from the Medical Ethics Committee of the Sun Yat-Sen
      University Cancer Center, we retrospectively reviewed data from 306 consecutive
      patients with histologically diagnosed esophageal squamous cell carcinoma who
      were treated between 2001 and 2011. All patients underwent radical McKeown-type
      esophagectomy with at least two-field lymphadenectomy. Regular follow-up was
      performed in our outpatient department. Postoperative complications and long-term
      survival were analyzed by treatment modality, baseline patient characteristics,
      and operative procedure. Data from patients treated via the retrosternal and
      posterior mediastinal routes were compared. RESULTS: The posterior mediastinal
      and retrosternal reconstruction routes were employed in 120 and 186 patients,
      respectively. Pulmonary complications were the most common complications
      experienced during the postoperative period (46.1% of all patients; 141/306).
      Compared to the retrosternal route, the posterior mediastinal reconstruction
      route was associated with a lower incidence of anastomotic stricture (15.8% vs
      27.4%, P = 0.018) and less surgical bleeding (242.8 +/- 114.2 mL vs 308.2 +/-
      168.4 mL, P < 0.001). The median survival time was 26.8 mo (range: 1.6-116.1 mo).
      Upon uni/multivariate analysis, a lower preoperative albumin level (P = 0.009)
      and a more advanced pathological stage (pT; P = 0.006; pN; P < 0.001) were
      identified as independent factors predicting poor prognosis. The reconstruction
      route did not influence prognosis (P = 0.477). CONCLUSION: The posterior
      mediastinal route of reconstruction reduces incidence of postoperative
      complications but does not affect survival. This route is recommended for
      resectable esophageal squamous cell carcinoma.
FAU - Zheng, Yu-Zhen
AU  - Zheng YZ
AD  - Department of Thoracic Oncology, Sun Yat-Sen University Cancer Center, No.651,
      Dongfeng Road East, Guangzhou, GuangdongProvince, China. zhengyzh@sysucc.org.cn
FAU - Dai, Shu-Qin
AU  - Dai SQ
FAU - Li, Wei
AU  - Li W
FAU - Cao, Xun
AU  - Cao X
FAU - Wang, Xin
AU  - Wang X
FAU - Fu, Jian-Hua
AU  - Fu JH
FAU - Lin, Peng
AU  - Lin P
FAU - Zhang, Lan-Jun
AU  - Zhang LJ
FAU - Lu, Bin
AU  - Lu B
FAU - Wang, Jun-Ye
AU  - Wang JY
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/mortality/*surgery
MH  - China/epidemiology
MH  - Esophageal Neoplasms/mortality/*surgery
MH  - Esophageal Squamous Cell Carcinoma
MH  - Esophagoplasty/*methods
MH  - Female
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Postoperative Complications/epidemiology
MH  - Proportional Hazards Models
MH  - Retrospective Studies
PMC - PMC3482650
OTO - NOTNLM
OT  - Comparison
OT  - Esophageal carcinoma
OT  - Posterior mediastinal
OT  - Retrosternal
OT  - Route of reconstruction
EDAT- 2012/11/01 06:00
MHDA- 2014/04/23 06:00
CRDT- 2012/11/01 06:00
PHST- 2012/03/28 00:00 [received]
PHST- 2012/08/22 00:00 [revised]
PHST- 2012/08/26 00:00 [accepted]
PHST- 2012/11/01 06:00 [entrez]
PHST- 2012/11/01 06:00 [pubmed]
PHST- 2014/04/23 06:00 [medline]
AID - 10.3748/wjg.v18.i39.5616 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2012 Oct 21;18(39):5616-21. doi: 10.3748/wjg.v18.i39.5616.


PMID- 23112478
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121101
LR  - 20211021
IS  - 0974-5203 (Electronic)
IS  - 0972-0707 (Linking)
VI  - 15
IP  - 4
DP  - 2012 Oct
TI  - SealBio: A novel, non-obturation endodontic treatment based on concept of
      regeneration.
PG  - 328-32
LID - 10.4103/0972-0707.101889 [doi]
AB  - INTRODUCTION: "SealBio", an innovative, non-surgical endodontic treatment
      protocol, based on "regenerative concept" has been developed to manage pulp and
      periapically involved teeth. MATERIALS AND METHODS: Subsequent to Institute's
      ethical clearance, 18 patients presenting with signs and symptoms of pulp and
      periapical disease were included in the study. (11/M, 7/F; Mean age - 44.7 years;
      range 15-76 years). The protocol included a modified cleaning and shaping
      technique involving apical clearing and foramen widening, combined with inducing 
      bleeding and clot formation in the apical region. Calcium-sulphate based cement
      was condensed with hand pluggers into the canal orifices. An appropriate
      permanent restoration was given. The patients were followed-up clinically and
      radiographically at regular interval of 6 months. Six teeth in 3 patients were
      also evaluated pre and post treatment CBCT at 6-months. RESULTS: The novel
      treatment protocol was found to be favourable in resolving periapical infection, 
      both clinically and radiographically. CONCLUSIONS: This innovative endodontic
      treatment protocol highlights and reiterates the importance of cleaning and
      shaping and puts forth the possible role of stem cells and growth factors in
      healing after non-surgical endodontic therapy.
FAU - Shah, Naseem
AU  - Shah N
AD  - Department of Conservative Dentistry and Endodontics and Centre for Dental
      Education and Research, All India Institute of Medical Sciences, New Delhi,
      India.
FAU - Logani, Ajay
AU  - Logani A
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Conserv Dent
JT  - Journal of conservative dentistry : JCD
JID - 101147009
PMC - PMC3482744
OTO - NOTNLM
OT  - CBCT
OT  - non-obturation Endodontic treatment
OT  - periapical healing
OT  - regenerative endodontics
OT  - sealBio
EDAT- 2012/11/01 06:00
MHDA- 2012/11/01 06:01
CRDT- 2012/11/01 06:00
PHST- 2012/04/07 00:00 [received]
PHST- 2012/06/16 00:00 [revised]
PHST- 2012/07/19 00:00 [accepted]
PHST- 2012/11/01 06:00 [entrez]
PHST- 2012/11/01 06:00 [pubmed]
PHST- 2012/11/01 06:01 [medline]
AID - 10.4103/0972-0707.101889 [doi]
AID - JCD-15-328 [pii]
PST - ppublish
SO  - J Conserv Dent. 2012 Oct;15(4):328-32. doi: 10.4103/0972-0707.101889.


PMID- 23112044
OWN - NLM
STAT- MEDLINE
DCOM- 20130527
LR  - 20141120
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 4
DP  - 2013 Apr
TI  - Great expectations--ethics, avian flu and the value of progress.
PG  - 209-13
LID - 10.1136/medethics-2012-100712 [doi]
AB  - A recent controversy over the US National Science Advisory Board for
      Biosecurity's recommendation to censor two publications on genetically modified
      H5N1 avian influenza has generated concern over the threat to scientific freedom 
      such censorship presents. In this paper, I argue that in the case of these
      studies, appeals to scientific freedom are not sufficient to motivate a rejection
      of censorship. I then use this conclusion to draw broader concerns about the
      ethics of dual-use research.
FAU - Evans, Nicholas G
AU  - Evans NG
AD  - School of Philosophy, ANU, Canberra, Australia. Nick.evans@anu.edu.au
LA  - eng
PT  - Journal Article
DEP - 20121030
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Animals
MH  - Biomedical Research/*ethics
MH  - Bioterrorism/*prevention & control
MH  - Birds
MH  - Ferrets
MH  - Global Health
MH  - Humans
MH  - *Influenza A Virus, H5N1 Subtype/genetics/isolation & purification/pathogenicity
MH  - Influenza in Birds/transmission
MH  - Influenza, Human/*transmission/*virology
MH  - Public Health
MH  - Publishing/*ethics
MH  - *Research Report/legislation & jurisprudence
MH  - United States
EDAT- 2012/11/01 06:00
MHDA- 2013/05/29 06:00
CRDT- 2012/11/01 06:00
PHST- 2012/11/01 06:00 [entrez]
PHST- 2012/11/01 06:00 [pubmed]
PHST- 2013/05/29 06:00 [medline]
AID - medethics-2012-100712 [pii]
AID - 10.1136/medethics-2012-100712 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Apr;39(4):209-13. doi: 10.1136/medethics-2012-100712. Epub
      2012 Oct 30.


PMID- 23112043
OWN - NLM
STAT- MEDLINE
DCOM- 20130304
LR  - 20171116
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 1
DP  - 2013 Jan
TI  - Monitoring 'monitoring' and evaluating 'evaluation': an ethical framework for
      monitoring and evaluation in public health.
PG  - 31-5
LID - 10.1136/medethics-2012-100680 [doi]
AB  - Monitoring and evaluation (M&E) is an essential part of public health programmes.
      Since M&E is the backbone of public health programmes, ethical considerations are
      important in their conduct. Some of the key ethical considerations are avoiding
      conflicts of interest, maintaining independence of judgement, maintaining
      fairness, transparency, full disclosure, privacy and confidentiality, respect,
      responsibility, accountability, empowerment and sustainability. There are several
      ethical frameworks in public health, but none focusing on the monitoring and
      evaluation process. There is a need to institutionalise the ethical review of M&E
      proposals. A theoretical framework for ethical considerations is proposed in this
      paper. This proposed theoretical framework can act as the blueprint for building 
      the capacity of ethics committees to review M&E proposals. A case study is
      discussed in this context. After thorough field testing, this practical and
      field-based ethical framework can be widely used by donor agencies, M&E teams,
      institutional review boards and ethics committees.
FAU - Gopichandran, Vijayaprasad
AU  - Gopichandran V
AD  - School of Public Health, SRM University, Kattankulathur, Tamil Nadu, India.
      vijay.gopichandran@gmail.com
FAU - Indira Krishna, Anil Kumar
AU  - Indira Krishna AK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121030
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Bias
MH  - Confidentiality
MH  - Conflict of Interest
MH  - Disclosure
MH  - Effect Modifier, Epidemiologic
MH  - *Evaluation Studies as Topic
MH  - Health Services Research/standards
MH  - Humans
MH  - India
MH  - Judgment
MH  - Program Evaluation/*standards
MH  - Public Health/*ethics
MH  - Social Responsibility
EDAT- 2012/11/01 06:00
MHDA- 2013/03/05 06:00
CRDT- 2012/11/01 06:00
PHST- 2012/11/01 06:00 [entrez]
PHST- 2012/11/01 06:00 [pubmed]
PHST- 2013/03/05 06:00 [medline]
AID - medethics-2012-100680 [pii]
AID - 10.1136/medethics-2012-100680 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Jan;39(1):31-5. doi: 10.1136/medethics-2012-100680. Epub 2012 
      Oct 30.


PMID- 23112014
OWN - NLM
STAT- MEDLINE
DCOM- 20131210
LR  - 20121031
IS  - 0037-5675 (Print)
IS  - 0037-5675 (Linking)
VI  - 53
IP  - 10
DP  - 2012 Oct
TI  - Incidence and outcome of prenatally diagnosed, chromosomally normal congenital
      heart defects in Singapore.
PG  - 643-7
AB  - INTRODUCTION: Congenital heart defect (CHD) is a significant cause of neonatal
      and infant mortality. We aimed to evaluate the incidence and pregnancy outcome of
      foetuses diagnosed with chromosomally normal CHD in KK Women's and Children's
      Hospital (KKH), Singapore, in 2008-2009. METHODS: We reviewed the medical records
      of pregnant women who underwent first trimester screening and were diagnosed with
      foetal CHD at KKH. Additional information was obtained from the Birth Defect
      Registry for the period 2008-2009. Foetuses with abnormal karyotype or minor
      lesions not expected to be detected by ultrasonography were excluded. RESULTS: 38
      out of 9,834 euploid foetuses were diagnosed with CHD. Major defects were found
      in 26 (68%) foetuses, while 12 (32%) had minor CHDs. Tetralogy of Fallot,
      atrioventricular septal defect, hypoplastic left heart syndrome, transposition of
      the great arteries and ventricular septal defect constituted the five most common
      major CHDs observed. In 14 (54%) foetuses with prenatally diagnosed major CHD,
      the outcome was termination of pregnancy, while 12 (46%) pregnancies continued to
      birth. Among the live-born babies with major CHD, eight (67%) underwent surgery. 
      CONCLUSION: The incidence of non-chromosomal major CHD in Singapore was about 2.6
      per 1,000 foetuses. A detection rate of 88.5% was achieved for major CHD during
      the study period. Advances in CHD management have thrown up new challenges for
      clinicians in the area of diagnosis, treatment and ethics. Therefore, it may be
      beneficial to constitute a regulatory entity as a fundamental guide to improve
      the future management of foetuses diagnosed with CHD.
FAU - Dhanardhono, Tuntas
AU  - Dhanardhono T
AD  - Department of Forensic and Legal Medicine, Faculty of Medicine, Diponegoro
      University, Central Java, Indonesia.
FAU - Thia, Edwin
AU  - Thia E
FAU - Wei, Xing
AU  - Wei X
FAU - Saktini, Fanti
AU  - Saktini F
FAU - Dewi, Puspita Kusuma
AU  - Dewi PK
FAU - Yeo, George S H
AU  - Yeo GS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Singapore
TA  - Singapore Med J
JT  - Singapore medical journal
JID - 0404516
SB  - IM
MH  - Female
MH  - Heart Defects, Congenital/diagnosis/*epidemiology/genetics
MH  - Humans
MH  - Incidence
MH  - Karyotyping
MH  - Male
MH  - Pregnancy
MH  - Pregnancy Outcome/epidemiology
MH  - Pregnancy Trimester, First
MH  - Prenatal Diagnosis/*statistics & numerical data
MH  - Singapore/epidemiology
EDAT- 2012/11/01 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/11/01 06:00
PHST- 2012/11/01 06:00 [entrez]
PHST- 2012/11/01 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
PST - ppublish
SO  - Singapore Med J. 2012 Oct;53(10):643-7.


PMID- 23111884
OWN - NLM
STAT- MEDLINE
DCOM- 20130826
LR  - 20131121
IS  - 1477-0903 (Electronic)
IS  - 0960-3271 (Linking)
VI  - 32
IP  - 3
DP  - 2013 Mar
TI  - Estimation of BDNF gene polymorphism and predisposition to dependence development
      for selected psychoactive compounds: genetic aspects of addiction with the
      selected drugs, amphetamine, tetrahydrocannabinol and opiates.
PG  - 236-40
LID - 10.1177/0960327112459203 [doi]
AB  - The etiology of drug addiction, a central nervous system (CNS) disease, is not
      fully known. This complex problem is believed to be connected with concurrently
      affecting genetic, psychological and environmental factors. The development of
      addiction is connected with CNS reinforcement system and dopaminergic
      neurotransmission. Molecular processes are postulated to be of universal
      character and allow to presume a similar mechanism of dependence for both ethanol
      and other substances. Therefore, elements of dopaminergic transmission become
      excellent candidates for the examination of genetic influence on the development 
      of addiction. A relationship between alcoholic disease and the presence of TaqIA1
      and DRD2 alleles permits to initiate another investigation of gene-coding DRD2
      dopamine receptor. The latest results indicate the importance of brain-derived
      neurotrophic factor (BDNF) in the regulation of dopaminergic route. The purpose
      of this research was to reveal the relationship between the Val66Met BDNF gene
      polymorphism and dependence of psychoactive agent. The examinations were
      performed with the Local Research Ethics Committee approval and patient's
      consent. The study group consisted of 100 patients (88 men and 12 women) aged
      18-52 years, qualified for research program according to the International
      Classification of Diseases, Tenth Revision (ICD-10) requirements, medical
      examination and detailed questionnaire.
FAU - Biskupska, J
AU  - Biskupska J
AD  - Division of Clinical Toxicology and Pathobiochemistry, Department of Forensic
      Medicine, Pomeranian University of Medicine, Szczecin, Poland.
FAU - Borowiak, K S
AU  - Borowiak KS
FAU - Karlin-Grazewicz, K
AU  - Karlin-Grazewicz K
FAU - Janus, T
AU  - Janus T
FAU - Waloszczyk, P
AU  - Waloszczyk P
FAU - Potocka-Banas, B
AU  - Potocka-Banas B
FAU - Machoy-Mokrzynska, A
AU  - Machoy-Mokrzynska A
FAU - Ossowski, A
AU  - Ossowski A
FAU - Ciechanowicz, A
AU  - Ciechanowicz A
LA  - eng
PT  - Journal Article
DEP - 20121030
PL  - England
TA  - Hum Exp Toxicol
JT  - Human & experimental toxicology
JID - 9004560
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Opiate Alkaloids)
RN  - 0 (Psychotropic Drugs)
RN  - 7J8897W37S (Dronabinol)
RN  - CK833KGX7E (Amphetamine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Amphetamine
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Dronabinol
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Opiate Alkaloids
MH  - Polymorphism, Genetic
MH  - Psychotropic Drugs
MH  - Substance-Related Disorders/*genetics
MH  - Young Adult
EDAT- 2012/11/01 06:00
MHDA- 2013/08/27 06:00
CRDT- 2012/11/01 06:00
PHST- 2012/11/01 06:00 [entrez]
PHST- 2012/11/01 06:00 [pubmed]
PHST- 2013/08/27 06:00 [medline]
AID - 0960327112459203 [pii]
AID - 10.1177/0960327112459203 [doi]
PST - ppublish
SO  - Hum Exp Toxicol. 2013 Mar;32(3):236-40. doi: 10.1177/0960327112459203. Epub 2012 
      Oct 30.


PMID- 23111721
OWN - NLM
STAT- MEDLINE
DCOM- 20131119
LR  - 20131121
IS  - 1550-5073 (Electronic)
IS  - 0893-2190 (Linking)
VI  - 26
IP  - 4
DP  - 2012 Oct-Dec
TI  - Ethical decision making in intrapartum nursing.
PG  - 327-35
LID - 10.1097/JPN.0b013e3182694df2 [doi]
AB  - Nurses are confronted daily with making ethical decisions in practice, in which
      the "right" or best course of action must be determined. However, for intrapartum
      nurses, the seemingly ordinary nature of ethical issues means that these concerns
      may be viewed merely as clinical or logistical problems to be solved, leaving the
      ethical dimensions obscured. This has consequences not only for women and the
      provision of safe, family-centered maternity care but also for the quality of
      nurses' work environments and degree of moral distress experienced. This article 
      explores ethical aspects of intrapartum nursing by applying ethical principles
      and moral reasoning to an "everyday" situation encountered by intrapartum nurses 
      in practice. Implications for practice and the development of healthy moral
      communities are considered.
FAU - Simmonds, Anne H
AU  - Simmonds AH
AD  - Lawrence S. Bloomberg Faculty of Nursing, University of Toronto, Toronto,
      Ontario, Canada. anne.simmonds@utoronto.ca
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Perinat Neonatal Nurs
JT  - The Journal of perinatal & neonatal nursing
JID - 8801387
MH  - *Clinical Competence
MH  - Decision Making/*ethics
MH  - Delivery, Obstetric/ethics/*nursing
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Morals
MH  - Nurse's Role
MH  - Nurse-Patient Relations
MH  - Obstetric Nursing/*ethics
MH  - Parturition
MH  - Pregnancy
MH  - Problem Solving/*ethics
EDAT- 2012/11/01 06:00
MHDA- 2013/11/20 06:00
CRDT- 2012/11/01 06:00
PHST- 2012/11/01 06:00 [entrez]
PHST- 2012/11/01 06:00 [pubmed]
PHST- 2013/11/20 06:00 [medline]
AID - 10.1097/JPN.0b013e3182694df2 [doi]
AID - 00005237-201210000-00011 [pii]
PST - ppublish
SO  - J Perinat Neonatal Nurs. 2012 Oct-Dec;26(4):327-35. doi:
      10.1097/JPN.0b013e3182694df2.


PMID- 23111704
OWN - NLM
STAT- MEDLINE
DCOM- 20130423
LR  - 20121105
IS  - 1751-4266 (Electronic)
IS  - 1751-4258 (Linking)
VI  - 6
IP  - 4
DP  - 2012 Dec
TI  - Self-management in palliative medicine.
PG  - 432-7
LID - 10.1097/SPC.0b013e32835a7011 [doi]
AB  - PURPOSE OF REVIEW: Self-management in the palliative care domain means equipping 
      patients and carers to manage medical aspects of illness, managing life roles and
      allowing adaptation to the changing dynamics brought on by illness and its
      progression. As well as dealing with the psychological consequences of living
      with a life-threatening illness in which the aim is to optimise living. This
      review will consider the rationale for developing and adopting self-management as
      a model of care. RECENT FINDINGS: Health policy currently advocates de-investment
      in traditional approaches to patient management paralleled with a re-engineering 
      of services towards approaches required to underpin self-management care.
      However, the literature suggests that patients lack a fundamental knowledge and
      more importantly an understanding of the progression of their illness or what
      palliative of hospice care is. As a first step, this issue must be addressed in
      any self-management intervention. In terms of outcomes evidence continues to
      emerge that when compared with care self-management imparts sustainable
      understanding in targeted areas and has the potential to create a preventive
      spend environment. SUMMARY: The role of self-management in palliative care
      requires further elucidation yet based on the evidence which is predominately
      gleaned from long-term conditions it would seem sensible if not ethical to
      educate patients/carers to actively be involved in decision making.
FAU - Davidson, Isobel
AU  - Davidson I
AD  - Dietetics, Nutrition and Biological Sciences, Queen Margaret University
      Edinburgh, UK.
FAU - Whyte, Fiona
AU  - Whyte F
FAU - Richardson, Rosemary
AU  - Richardson R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Curr Opin Support Palliat Care
JT  - Current opinion in supportive and palliative care
JID - 101297402
SB  - IM
MH  - Caregivers
MH  - *Disease Management
MH  - Europe
MH  - Humans
MH  - North America
MH  - *Palliative Care/methods/organization & administration
MH  - *Patient Participation
MH  - Program Development
MH  - *Self Care
MH  - Self Efficacy
EDAT- 2012/11/01 06:00
MHDA- 2013/04/24 06:00
CRDT- 2012/11/01 06:00
PHST- 2012/11/01 06:00 [entrez]
PHST- 2012/11/01 06:00 [pubmed]
PHST- 2013/04/24 06:00 [medline]
AID - 10.1097/SPC.0b013e32835a7011 [doi]
PST - ppublish
SO  - Curr Opin Support Palliat Care. 2012 Dec;6(4):432-7. doi:
      10.1097/SPC.0b013e32835a7011.


PMID- 23111046
OWN - NLM
STAT- MEDLINE
DCOM- 20130422
LR  - 20151119
IS  - 1878-7452 (Electronic)
IS  - 1878-7452 (Linking)
VI  - 69
IP  - 6
DP  - 2012 Nov-Dec
TI  - Proficiency of surgical faculty and residents with ethical dilemmas: is modeling 
      enough?
PG  - 780-4
LID - 10.1016/j.jsurg.2012.04.014 [doi]
LID - S1931-7204(12)00106-7 [pii]
AB  - OBJECTIVE: Professionalism, an Accreditation Commission for Graduate Medical
      Education (ACGME) competency, embraces the concept of adherence to ethical
      principles. Despite this, most surgical residencies do not currently include
      ethics as part of their core curriculum. Further, expertise in effectively
      managing ethical dilemmas is frequently obtained via modeling after the attending
      physician. This study evaluated surgical faculty (SF) and residents (SR) on their
      understanding of basic ethical principles and their overall confidence in
      translation of these principles into clinical practice. The objective was to
      determine if there are any differences in the overall levels of knowledge and
      confidence in ethics between SR and SF. DESIGN AND SETTING: Immediately before
      the first session of a Kamangar Grant supported monthly Ethics Forum, all SF and 
      SR completed a Pre-Curriculum Questionnaire (PCQ) on their knowledge about
      ethical principles and their confidence in dealing with ethical issues. PQC
      contained 13 multiple-choice and true/false knowledge questions and 8 questions
      evaluating confidence rated on a 5-point Likert scale. PARTICIPANTS: Surgical
      faculty (SF) (n = 16) and SR (n = 36). Knowledge and confidence scores were
      compared between SR and SF, using Student t-test analysis to evaluate differences
      between groups. RESULTS: No significant differences were found in ethical
      knowledge scores between faculty and residents. Faculty confidence is higher than
      resident (p < 0.05). Further, female faculty confidence is higher than that of
      their male counterparts (p < 0.05). CONCLUSIONS: While SF are more confident in
      their ethical decision-making, their fundamental knowledge base in ethics is not 
      different from that of SR. Female SF report greater self-confidence over their
      male counterparts. In total, SF may not possess the foundation to effectively
      mentor residents in appropriate ethical principles and their translation to
      clinical practice. This study supports the need for both SR and SF to engage in
      an integrated education program in ethics to promote on-going dialogue in this
      complex topic.
CI  - Copyright (c) 2012 Association of Program Directors in Surgery. Published by
      Elsevier Inc. All rights reserved.
FAU - Scott, Kamela K
AU  - Scott KK
AD  - Department of Surgery, University of Florida College of Medicine-Jacksonville,
      Jacksonville, FL 32209, USA. kamela.scott@jax.ufl.edu
FAU - Chesire, David J
AU  - Chesire DJ
FAU - Burns, J Bracken Jr
AU  - Burns JB Jr
FAU - Nussbaum, Michael S
AU  - Nussbaum MS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20120523
PL  - United States
TA  - J Surg Educ
JT  - Journal of surgical education
JID - 101303204
SB  - IM
MH  - Clinical Competence
MH  - Ethics, Medical/*education
MH  - *Faculty, Medical
MH  - Female
MH  - Humans
MH  - *Internship and Residency
MH  - Male
MH  - Middle Aged
MH  - Models, Educational
MH  - Specialties, Surgical/*ethics
MH  - Surveys and Questionnaires
EDAT- 2012/11/01 06:00
MHDA- 2013/04/23 06:00
CRDT- 2012/11/01 06:00
PHST- 2012/03/16 00:00 [received]
PHST- 2012/04/11 00:00 [revised]
PHST- 2012/04/16 00:00 [accepted]
PHST- 2012/11/01 06:00 [entrez]
PHST- 2012/11/01 06:00 [pubmed]
PHST- 2013/04/23 06:00 [medline]
AID - S1931-7204(12)00106-7 [pii]
AID - 10.1016/j.jsurg.2012.04.014 [doi]
PST - ppublish
SO  - J Surg Educ. 2012 Nov-Dec;69(6):780-4. doi: 10.1016/j.jsurg.2012.04.014. Epub
      2012 May 23.


PMID- 23110987
OWN - NLM
STAT- MEDLINE
DCOM- 20130607
LR  - 20130107
IS  - 1523-6536 (Electronic)
IS  - 1083-8791 (Linking)
VI  - 19
IP  - 1 Suppl
DP  - 2013 Jan
TI  - Hematopoietic cell transplantation for thalassemia: a global perspective BMT
      tandem meeting 2013.
PG  - S70-3
LID - 10.1016/j.bbmt.2012.10.025 [doi]
LID - S1083-8791(12)00454-5 [pii]
AB  - Hematopoietic cell transplantation (HCT) remains the sole available curative
      option for patients with beta-thalassemia major. Expanded and improved supportive
      therapies for thalassemia now routinely extend the life span of affected
      individuals well into adulthood. Consequently, in regions of the world where this
      care is readily available, HCT has been pursued infrequently, in part owing to
      concerns about an expected lack of balance between risks and benefits. More
      recently, however, recognition of significant health problems in older patients
      with thalassemia, along with recognition of increased risks of graft-versus-host 
      disease (GVHD), graft rejection, and impaired organ function leading to inferior 
      HCT outcomes in this particular group, seem to be turning the wheels and tipping 
      the balance again in the direction of consideration for earlier HCTs. In
      contrast, in countries where thalassemia is most prevalent (>100,000 new children
      born each year in Middle East and southeast Asia), lack of supportive care
      standards together with often insufficient access to dedicated health care
      facilities, results in the majority of these children not reaching adulthood,
      further supporting the need for expanded access to HCT for these patients. The
      cost of HCT is equivalent to that of a few years of noncurative supportive care, 
      such that HCT in low-risk young children with a compatible sibling is justified
      not only medically and ethically but also financially. International cooperation 
      can play a major role in increasing access to safe and affordable HCT in
      countries where there is a considerable shortage of transplantation centers. In
      this article, we review the current status of bone marrow transplantation for
      thalassemia major, with particular emphasis on a global prospective.
CI  - Copyright (c) 2013 American Society for Blood and Marrow Transplantation.
      Published by Elsevier Inc. All rights reserved.
FAU - Mehta, Parinda A
AU  - Mehta PA
AD  - Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati
      Children's Hospital Medical Center, Cincinnati, Ohio.
FAU - Faulkner, Lawrence B
AU  - Faulkner LB
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121027
PL  - United States
TA  - Biol Blood Marrow Transplant
JT  - Biology of blood and marrow transplantation : journal of the American Society for
      Blood and Marrow Transplantation
JID - 9600628
SB  - IM
MH  - Congresses as Topic
MH  - Graft Rejection/economics/mortality/therapy
MH  - Graft vs Host Disease/economics/mortality/therapy
MH  - Hematopoietic Stem Cell Transplantation/economics/*methods
MH  - Hospitals, Special/economics/supply & distribution
MH  - Humans
MH  - Longevity
MH  - Transplantation, Homologous
MH  - beta-Thalassemia/economics/mortality/*therapy
EDAT- 2012/11/01 06:00
MHDA- 2013/06/08 06:00
CRDT- 2012/11/01 06:00
PHST- 2012/11/01 06:00 [entrez]
PHST- 2012/11/01 06:00 [pubmed]
PHST- 2013/06/08 06:00 [medline]
AID - S1083-8791(12)00454-5 [pii]
AID - 10.1016/j.bbmt.2012.10.025 [doi]
PST - ppublish
SO  - Biol Blood Marrow Transplant. 2013 Jan;19(1 Suppl):S70-3. doi:
      10.1016/j.bbmt.2012.10.025. Epub 2012 Oct 27.


PMID- 23110633
OWN - NLM
STAT- MEDLINE
DCOM- 20130204
LR  - 20211021
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 13
DP  - 2012 Oct 30
TI  - "Snake-oil," "quack medicine," and "industrially cultured organisms:" biovalue
      and the commercialization of human microbiome research.
PG  - 28
LID - 10.1186/1472-6939-13-28 [doi]
AB  - BACKGROUND: Continued advances in human microbiome research and technologies
      raise a number of ethical, legal, and social challenges. These challenges are
      associated not only with the conduct of the research, but also with broader
      implications, such as the production and distribution of commercial products
      promising maintenance or restoration of good physical health and disease
      prevention. In this article, we document several ethical, legal, and social
      challenges associated with the commercialization of human microbiome research,
      focusing particularly on how this research is mobilized within economic markets
      for new public health uses. METHODS: We conducted in-depth, semi-structured
      interviews (2009-2010) with 63 scientists, researchers, and National Institutes
      of Health project leaders ("investigators") involved with human microbiome
      research. Interviews explored a range of ethical, legal, and social dimensions of
      human microbiome research, including investigators' perspectives on
      commercialization. Using thematic content analysis, we identified and analyzed
      emergent themes and patterns. RESULTS: Investigators discussed the
      commercialization of human microbiome research in terms of (1) commercialization,
      probiotics, and issues of safety, (2) public awareness of the benefits and risks 
      of dietary supplements, and (3) regulation. CONCLUSION: The prevailing theme of
      ethical, legal, social concern focused on the need to find a balance between the 
      marketplace, scientific research, and the public's health. The themes we
      identified are intended to serve as points for discussions about the relationship
      between scientific research and the manufacture and distribution of
      over-the-counter dietary supplements in the United States.
FAU - Slashinski, Melody J
AU  - Slashinski MJ
AD  - Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston,
      TX 77030, USA. melody.slashinski@bcm.edu
FAU - McCurdy, Sheryl A
AU  - McCurdy SA
FAU - Achenbaum, Laura S
AU  - Achenbaum LS
FAU - Whitney, Simon N
AU  - Whitney SN
FAU - McGuire, Amy L
AU  - McGuire AL
LA  - eng
GR  - R01HG004853/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20121030
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Awareness
MH  - *Commerce
MH  - Dietary Supplements
MH  - Drug Industry/*ethics
MH  - Ethics, Research
MH  - Humans
MH  - *Metagenome
MH  - *Probiotics
MH  - Public Health
MH  - Public Opinion
MH  - Quackery/*ethics
MH  - *Research
MH  - *Technology Transfer
PMC - PMC3512494
EDAT- 2012/11/01 06:00
MHDA- 2013/02/05 06:00
CRDT- 2012/11/01 06:00
PHST- 2012/05/02 00:00 [received]
PHST- 2012/10/15 00:00 [accepted]
PHST- 2012/11/01 06:00 [entrez]
PHST- 2012/11/01 06:00 [pubmed]
PHST- 2013/02/05 06:00 [medline]
AID - 1472-6939-13-28 [pii]
AID - 10.1186/1472-6939-13-28 [doi]
PST - epublish
SO  - BMC Med Ethics. 2012 Oct 30;13:28. doi: 10.1186/1472-6939-13-28.


PMID- 23110513
OWN - NLM
STAT- MEDLINE
DCOM- 20130122
LR  - 20121115
IS  - 1532-5415 (Electronic)
IS  - 0002-8614 (Linking)
VI  - 60
IP  - 11
DP  - 2012 Nov
TI  - Medical decision-making for older adults without family.
PG  - 2144-50
LID - 10.1111/j.1532-5415.2012.04212.x [doi]
AB  - Each year in the United States, individuals who lack decision-making capacity
      because of acute or chronic cognitive impairment are in situations in which
      important medical decisions must be made for them, but tens of thousands of these
      individuals have no known family members or designated surrogates available to
      help with those decisions. Such individuals constitute 16% of patients in
      intensive care units, 3% of nursing home residents, and a large but unspecified
      number of individuals in a variety of settings who are facing end-of-life
      decisions. Several approaches are currently used to aid in medical
      decision-making for people without families or designated surrogates, including
      hospital ethics committees, court-appointed surrogate agents, reliance on advance
      directives if they are available, and even the use of computer-based decision
      systems. These approaches all have limitations and often result in individuals
      receiving care that would not have been their preference. Additionally, because
      clinical care teams must wrestle with uncertainty about best approaches to care, 
      lengths of hospital stay for individuals without family are longer, resulting in 
      higher healthcare costs and potentially more-aggressive interventions than
      individuals with family experience. This article reviews medical decision-making 
      for older adults without families or designated surrogates and proposes a
      solution: "health fiduciaries"--a new type of professional trained and certified 
      to act as a surrogate decision-maker for individuals who are unable to make
      decisions for themselves.
CI  - (c) 2012, Copyright the Authors Journal compilation (c) 2012, The American
      Geriatrics Society.
FAU - Weiss, Barry D
AU  - Weiss BD
AD  - Center on Aging, University of Arizona, Tucson, Arizona 85719, USA.
      bdweiss@u.arizona.edu
FAU - Berman, Elena A
AU  - Berman EA
FAU - Howe, Carol L
AU  - Howe CL
FAU - Fleming, Robert B
AU  - Fleming RB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
DEP - 20121030
PL  - United States
TA  - J Am Geriatr Soc
JT  - Journal of the American Geriatrics Society
JID - 7503062
SB  - IM
MH  - *Advance Directives
MH  - Aged
MH  - *Decision Making
MH  - Family
MH  - Humans
MH  - Mental Competency
MH  - Practice Guidelines as Topic
EDAT- 2012/11/01 06:00
MHDA- 2013/01/23 06:00
CRDT- 2012/11/01 06:00
PHST- 2012/11/01 06:00 [entrez]
PHST- 2012/11/01 06:00 [pubmed]
PHST- 2013/01/23 06:00 [medline]
AID - 10.1111/j.1532-5415.2012.04212.x [doi]
PST - ppublish
SO  - J Am Geriatr Soc. 2012 Nov;60(11):2144-50. doi: 10.1111/j.1532-5415.2012.04212.x.
      Epub 2012 Oct 30.


PMID- 23097484
OWN - NLM
STAT- MEDLINE
DCOM- 20130419
LR  - 20121025
IS  - 1473-0480 (Electronic)
IS  - 0306-3674 (Linking)
VI  - 46 Suppl 1
DP  - 2012 Nov
TI  - Performance enhancing drug abuse and cardiovascular risk in athletes:
      implications for the clinician.
PG  - i78-84
LID - 10.1136/bjsports-2012-091186 [doi]
AB  - The use of performance-enhancing and social drugs by athletes raises a number of 
      ethical and health concerns. The World Anti-Doping Agency was constituted to
      address both of these issues as well as publishing a list of, and testing for,
      banned substances in athletes. Despite continuing methodological developments to 
      detect drug use and associated punishments for positive dope tests, there are
      still many athletes who choose to use performance and image enhancing drugs. Of
      primary concern to this review are the health consequences of drug use by
      athletes. For such a large topic we must put in place delimitations.
      Specifically, we will address current knowledge, controversies and emerging
      evidence in relation to cardiovascular (CV) health of athletes taking drugs.
      Further, we delimit our discussion to the CV consequences of anabolic steroids
      and stimulant (including amphetamines and cocaine) use. These drugs are reported 
      in the majority of adverse findings in athlete drug screenings and thus are more 
      likely to be relevant to the healthcare professionals responsible for the
      well-being of athletes. In detailing CV health issues related to anabolic steroid
      and stimulant abuse by athletes we critique current research evidence, present
      exemplar case studies and suggest important avenues for on-going research.
      Specifically we prompt the need for awareness of clinical staff when assessing
      the potential CV consequences of drug use in athletes.
FAU - Angell, Peter J
AU  - Angell PJ
AD  - Research Institute for Sport and Exercise Sciences, Liverpool John Moores
      University, Liverpool, UK. P.Angell@2004.ljmu.ac.uk
FAU - Chester, Neil
AU  - Chester N
FAU - Sculthorpe, Nick
AU  - Sculthorpe N
FAU - Whyte, Greg
AU  - Whyte G
FAU - George, Keith
AU  - George K
FAU - Somauroo, John
AU  - Somauroo J
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - England
TA  - Br J Sports Med
JT  - British journal of sports medicine
JID - 0432520
RN  - 0 (Amphetamines)
RN  - 0 (Anabolic Agents)
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Performance-Enhancing Substances)
SB  - IM
MH  - Adult
MH  - Amphetamines/adverse effects
MH  - Anabolic Agents/adverse effects
MH  - Athletes
MH  - Cardiovascular Diseases/*chemically induced
MH  - Central Nervous System Stimulants/adverse effects
MH  - Cocaine-Related Disorders/complications
MH  - Coronary Angiography
MH  - Doping in Sports
MH  - Electrocardiography
MH  - Humans
MH  - Performance-Enhancing Substances/*adverse effects
MH  - Risk Factors
MH  - Substance-Related Disorders/complications
EDAT- 2012/11/01 06:00
MHDA- 2013/04/23 06:00
CRDT- 2012/10/26 06:00
PHST- 2012/10/26 06:00 [entrez]
PHST- 2012/11/01 06:00 [pubmed]
PHST- 2013/04/23 06:00 [medline]
AID - 46/Suppl_1/i78 [pii]
AID - 10.1136/bjsports-2012-091186 [doi]
PST - ppublish
SO  - Br J Sports Med. 2012 Nov;46 Suppl 1:i78-84. doi: 10.1136/bjsports-2012-091186.


PMID- 29776236
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1744-828X (Electronic)
IS  - 1741-0541 (Linking)
VI  - 9
IP  - 8
DP  - 2012 Nov
TI  - Your genes in insurance: from genetic discrimination to genomic solidarity.
PG  - 871-877
LID - 10.2217/pme.12.96 [doi]
AB  - Advances in genomics and postgenomics have renewed interest in the impact of
      genomic health information on private life insurance across Europe. These
      developments reopen the issue of how genes - apart from being the object of
      discrimination (exclusion) - also operate as generators of solidarity
      (inclusion). This article traces several developments in regulating genetics and 
      life insurance and its social implications in the European context. At first,
      genes were viewed as a source of differentiation, which led to fears of 'genetic 
      discrimination' in life insurance. In response, genetic nondiscrimination
      regulations were enacted across Europe. Current debates on the use of genomic
      health information in life insurance have actually opened up possibilities for a 
      form of genomic solidarity between 'all of us'. The introduction of genes and
      genomes appears to turn private life insurance practices of actuarial risk
      discrimination increasingly into 'discriminatory' practices by challenging the
      larger fundamental 'right to underwrite'.
FAU - Van Hoyweghen, Ine
AU  - Van Hoyweghen I
AD  - Department of Health, Ethics & Society (HES), CAPHRI, PO Box 616, 6200 MD
      Maastricht University, The Netherlands. i.vanhoyweghen@maastrichtuniversity.nl.
FAU - Rebert, Lisa
AU  - Rebert L
AD  - Department of Health, Ethics & Society (HES), CAPHRI, PO Box 616, 6200 MD
      Maastricht University, The Netherlands.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Per Med
JT  - Personalized medicine
JID - 101238549
OTO - NOTNLM
OT  - ethics
OT  - genetic discrimination
OT  - genetic nondiscrimination regulations
OT  - life insurance
OT  - nondiscrimination
OT  - social impact of personalized medicine
OT  - solidarity
EDAT- 2012/11/01 00:00
MHDA- 2012/11/01 00:01
CRDT- 2018/05/20 06:00
PHST- 2018/05/20 06:00 [entrez]
PHST- 2012/11/01 00:00 [pubmed]
PHST- 2012/11/01 00:01 [medline]
AID - 10.2217/pme.12.96 [doi]
PST - ppublish
SO  - Per Med. 2012 Nov;9(8):871-877. doi: 10.2217/pme.12.96.


PMID- 25049508
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140722
LR  - 20211021
IS  - 1011-2367 (Print)
IS  - 1011-2367 (Linking)
VI  - 25
IP  - 11
DP  - 2012 Nov
TI  - Animal welfare in different human cultures, traditions and religious faiths.
PG  - 1499-506
LID - 10.5713/ajas.2012.r.02 [doi]
AB  - Animal welfare has become a growing concern affecting acceptability of
      agricultural systems in many countries around the world. An earlier
      Judeo-Christian interpretation of the Bible (1982) that dominion over animals
      meant that any degree of exploitation was acceptable has changed for most people 
      to mean that each person has responsibility for animal welfare. This view was
      evident in some ancient Greek writings and has parallels in Islamic teaching. A
      minority view of Christians, which is a widespread view of Jains, Buddhists and
      many Hindus, is that animals should not be used by humans as food or for other
      purposes. The commonest philosophical positions now, concerning how animals
      should be treated, are a blend of deontological and utilitarian approaches. Most 
      people think that extremes of poor welfare in animals are unacceptable and that
      those who keep animals should strive for good welfare. Hence animal welfare
      science, which allows the evaluation of welfare, has developed rapidly.
FAU - Szucs, E
AU  - Szucs E
AD  - Catholic University of Leuven, Quality Care in Animal Production, Lovenjoel,
      Belgium .
FAU - Geers, R
AU  - Geers R
AD  - Catholic University of Leuven, Quality Care in Animal Production, Lovenjoel,
      Belgium .
FAU - Jezierski, T
AU  - Jezierski T
AD  - Polish Academy of Sciences, Institute of Genetics and Animal Breeding,
      Jastrzebiec, Poland .
FAU - Sossidou, E N
AU  - Sossidou EN
AD  - Hellenic Agricultural Organization-DEMETER, Directorate Generale of Agricultural 
      Research (formerly NAGREF), Veterinary Research Institute, Thermi-Thessaloniki,
      Greece .
FAU - Broom, D M
AU  - Broom DM
AD  - Centre for Animal Welfare and Anthrozoology, Department of Veterinary Medicine,
      University of Cambridge, Cambridge, UK .
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - Asian-Australas J Anim Sci
JT  - Asian-Australasian journal of animal sciences
JID - 9884245
PMC - PMC4093044
OTO - NOTNLM
OT  - Ancient and Modern Philosophies
OT  - Animal Welfare
OT  - Ethics
OT  - Religious Faiths
EDAT- 2012/11/01 00:00
MHDA- 2012/11/01 00:01
CRDT- 2014/07/23 06:00
PHST- 2014/07/23 06:00 [entrez]
PHST- 2012/11/01 00:00 [pubmed]
PHST- 2012/11/01 00:01 [medline]
AID - 10.5713/ajas.2012.r.02 [doi]
AID - ajas-25-11-1499-1 [pii]
PST - ppublish
SO  - Asian-Australas J Anim Sci. 2012 Nov;25(11):1499-506. doi:
      10.5713/ajas.2012.r.02.


PMID- 23110200
OWN - NLM
STAT- MEDLINE
DCOM- 20130426
LR  - 20211203
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 10
DP  - 2012
TI  - Induced pluripotent stem cells generated from human adipose-derived stem cells
      using a non-viral polycistronic plasmid in feeder-free conditions.
PG  - e48161
LID - 10.1371/journal.pone.0048161 [doi]
AB  - Induced pluripotent stem cells (iPSCs) can be generated from somatic cells by
      ectopic expression of defined transcription factors (TFs). However, the optimal
      cell type and the easy reprogramming approaches that minimize genetic aberrations
      of parent cells must be considered before generating the iPSCs. This paper
      reports a method to generate iPSCs from adult human adipose-derived stem cells
      (hADSCs) without the use of a feeder layer, by ectopic expression of the defined 
      transcription factors OCT4, SOX2, KLF4 and C-MYC using a polycistronic plasmid.
      The results, based on the expression of pluripotent marker, demonstrated that the
      iPSCs have the characteristics similar to those of embryonic stem cells (ESCs).
      The iPSCs differentiated into three embryonic germ layers both in vitro by
      embryoid body generation and in vivo by teratoma formation after being injected
      into immunodeficient mice. More importantly, the plasmid DNA does not integrate
      into the genome of human iPSCs as revealed by Southern blotting experiments.
      Karyotypic analysis also demonstrated that the reprogramming of hADSCs by the
      defined factors did not induce chromosomal abnormalities. Therefore, this
      technology provides a platform for studying the biology of iPSCs without viral
      vectors, and can hopefully overcome immune rejection and ethical concerns, which 
      are the two important barriers of ESC applications.
FAU - Qu, Xinjian
AU  - Qu X
AD  - Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of
      Technology, Liaoning, Dalian, China.
FAU - Liu, Tianqing
AU  - Liu T
FAU - Song, Kedong
AU  - Song K
FAU - Li, Xiangqin
AU  - Li X
FAU - Ge, Dan
AU  - Ge D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121026
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (KLF4 protein, human)
RN  - 0 (Klf4 protein, mouse)
RN  - 0 (Kruppel-Like Factor 4)
RN  - 0 (Kruppel-Like Transcription Factors)
RN  - 0 (MYC protein, human)
RN  - 0 (Octamer Transcription Factor-3)
RN  - 0 (Proto-Oncogene Proteins c-myc)
RN  - 0 (SOX2 protein, human)
RN  - 0 (SOXB1 Transcription Factors)
SB  - IM
MH  - Adipocytes/*cytology
MH  - Cell Differentiation/genetics/physiology
MH  - Embryoid Bodies/metabolism
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*cytology/*metabolism
MH  - Karyotype
MH  - Kruppel-Like Factor 4
MH  - Kruppel-Like Transcription Factors/genetics/metabolism
MH  - Octamer Transcription Factor-3/genetics/metabolism
MH  - Plasmids/*genetics
MH  - Proto-Oncogene Proteins c-myc/genetics/metabolism
MH  - SOXB1 Transcription Factors/genetics/metabolism
MH  - Stem Cells/*cytology/*metabolism
MH  - Teratoma/metabolism
PMC - PMC3482207
EDAT- 2012/10/31 06:00
MHDA- 2013/04/27 06:00
CRDT- 2012/10/31 06:00
PHST- 2012/04/02 00:00 [received]
PHST- 2012/09/21 00:00 [accepted]
PHST- 2012/10/31 06:00 [entrez]
PHST- 2012/10/31 06:00 [pubmed]
PHST- 2013/04/27 06:00 [medline]
AID - 10.1371/journal.pone.0048161 [doi]
AID - PONE-D-12-10418 [pii]
PST - ppublish
SO  - PLoS One. 2012;7(10):e48161. doi: 10.1371/journal.pone.0048161. Epub 2012 Oct 26.


PMID- 23110093
OWN - NLM
STAT- MEDLINE
DCOM- 20130411
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 10
DP  - 2012
TI  - Animal welfare in studies on murine tuberculosis: assessing progress over a
      12-year period and the need for further improvement.
PG  - e47723
LID - 10.1371/journal.pone.0047723 [doi]
AB  - There is growing concern over the welfare of animals used in research, in
      particular when these animals develop pathology. The present study aims to
      identify the main sources of animal distress and to assess the possible
      implementation of refinement measures in experimental infection research, using
      mouse models of tuberculosis (TB) as a case study. This choice is based on the
      historical relevance of mouse studies in understanding the disease and the
      present and long-standing impact of TB on a global scale. Literature published
      between 1997 and 2009 was analysed, focusing on the welfare impact on the animals
      used and the implementation of refinement measures to reduce this impact. In this
      12-year period, we observed a rise in reports of ethical approval of experiments.
      The proportion of studies classified into the most severe category did however
      not change significantly over the studied period. Information on important
      research parameters, such as method for euthanasia or sex of the animals, were
      absent in a substantial number of papers. Overall, this study shows that progress
      has been made in the application of humane endpoints in TB research, but that a
      considerable potential for improvement remains.
FAU - Franco, Nuno Henrique
AU  - Franco NH
AD  - IBMC - Institute for Molecular and Cell Biology, Laboratory Animal Science Group,
      University of Porto, Portugal. nfranco@ibmc.up.pt
FAU - Correia-Neves, Margarida
AU  - Correia-Neves M
FAU - Olsson, I Anna S
AU  - Olsson IA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20121026
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Animal Experimentation/ethics/*standards
MH  - Animal Welfare/*standards/trends
MH  - Animals
MH  - Chi-Square Distribution
MH  - *Disease Models, Animal
MH  - Mice
MH  - Tuberculosis, Pulmonary/*physiopathology
PMC - PMC3482232
EDAT- 2012/10/31 06:00
MHDA- 2013/04/12 06:00
CRDT- 2012/10/31 06:00
PHST- 2012/05/04 00:00 [received]
PHST- 2012/09/14 00:00 [accepted]
PHST- 2012/10/31 06:00 [entrez]
PHST- 2012/10/31 06:00 [pubmed]
PHST- 2013/04/12 06:00 [medline]
AID - 10.1371/journal.pone.0047723 [doi]
AID - PONE-D-12-13757 [pii]
PST - ppublish
SO  - PLoS One. 2012;7(10):e47723. doi: 10.1371/journal.pone.0047723. Epub 2012 Oct 26.


PMID- 23109913
OWN - NLM
STAT- MEDLINE
DCOM- 20130314
LR  - 20211021
IS  - 1549-1676 (Electronic)
IS  - 1549-1277 (Linking)
VI  - 9
IP  - 10
DP  - 2012
TI  - Research conducted using data obtained through online communities: ethical
      implications of methodological limitations.
PG  - e1001328
LID - 10.1371/journal.pmed.1001328 [doi]
FAU - Janssens, A Cecile J W
AU  - Janssens AC
AD  - Department of Epidemiology, Erasmus University Medical Center Rotterdam, The
      Netherlands. a.janssens@erasmusmc.nl
FAU - Kraft, Peter
AU  - Kraft P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121023
PL  - United States
TA  - PLoS Med
JT  - PLoS medicine
JID - 101231360
SB  - IM
MH  - Biomedical Research/*ethics/*methods
MH  - Data Collection/ethics/methods
MH  - Humans
MH  - Informed Consent
MH  - *Internet
PMC - PMC3479089
EDAT- 2012/10/31 06:00
MHDA- 2013/03/15 06:00
CRDT- 2012/10/31 06:00
PHST- 2012/10/31 06:00 [entrez]
PHST- 2012/10/31 06:00 [pubmed]
PHST- 2013/03/15 06:00 [medline]
AID - 10.1371/journal.pmed.1001328 [doi]
AID - PMEDICINE-D-12-00042 [pii]
PST - ppublish
SO  - PLoS Med. 2012;9(10):e1001328. doi: 10.1371/journal.pmed.1001328. Epub 2012 Oct
      23.


PMID- 23109685
OWN - NLM
STAT- MEDLINE
DCOM- 20130107
LR  - 20121102
IS  - 1098-4275 (Electronic)
IS  - 0031-4005 (Linking)
VI  - 130
IP  - 5
DP  - 2012 Nov
TI  - Human embryonic stem cell (hESC) and human embryo research.
PG  - 972-7
LID - 10.1542/peds.2012-2482 [doi]
AB  - Human embryonic stem cell research has emerged as an important platform for the
      understanding and treatment of pediatric diseases. From its inception, however,
      it has raised ethical concerns based not on the use of stem cells themselves but 
      on objections to the source of the cells--specifically, the destruction of
      preimplantation human embryos. Despite differences in public opinion on this
      issue, a large majority of the public supports continued research using embryonic
      stem cells. Given the possible substantial benefit of stem cell research on child
      health and development, the American Academy of Pediatrics believes that funding 
      and oversight for human embryo and embryonic stem cell research should continue.
FAU - Shand, Jessica
AU  - Shand J
FAU - Berg, Jessica
AU  - Berg J
FAU - Bogue, Clifford
AU  - Bogue C
CN  - Committee for Pediatric Research
CN  - Committee on Bioethics
LA  - eng
PT  - Journal Article
PT  - Practice Guideline
DEP - 20121029
PL  - United States
TA  - Pediatrics
JT  - Pediatrics
JID - 0376422
SB  - IM
MH  - *Embryo Research/ethics
MH  - *Embryonic Stem Cells
MH  - Humans
MH  - *Stem Cell Research/ethics
IR  - Denne SC
FIR - Denne, Scott C
IR  - Bauer AJ
FIR - Bauer, Andrew J
IR  - Cabana MD
FIR - Cabana, Michael D
IR  - Cheng TL
FIR - Cheng, Tina L
IR  - Notterman DA
FIR - Notterman, Daniel A
IR  - Scheindlin B
FIR - Scheindlin, Ben
IR  - Bergman JJ
FIR - Bergman, Jeffrey J
IR  - Shand J
FIR - Shand, Jessica
IR  - Bogue C
FIR - Bogue, Clifford
IR  - DeGraw CA
FIR - DeGraw, Christopher A
IR  - Dougherty D
FIR - Dougherty, Denise
IR  - Flores G
FIR - Flores, Glenn
IR  - Freed GL
FIR - Freed, Gary L
IR  - Goodman E
FIR - Goodman, Elizabeth
IR  - Guttmacher AE
FIR - Guttmacher, Alan E
IR  - Hillemeier A
FIR - Hillemeier, A Craig
IR  - Wang PP
FIR - Wang, Paul P
IR  - Cull W
FIR - Cull, William
IR  - Fallat ME
FIR - Fallat, Mary E
IR  - Katz AL
FIR - Katz, Aviva L
IR  - Mercurio MR
FIR - Mercurio, Mark R
IR  - Moon MR
FIR - Moon, Margaret R
IR  - Okun AL
FIR - Okun, Alexander L
IR  - Webb SA
FIR - Webb, Sally A
IR  - Weise KL
FIR - Weise, Kathryn L
IR  - Antommaria AH
FIR - Antommaria, Armand H Matheny
IR  - Holzman IR
FIR - Holzman, Ian R
IR  - Diekema DS
FIR - Diekema, Douglas S
IR  - Coughlin KW
FIR - Coughlin, Kevin W
IR  - Ralston SJ
FIR - Ralston, Steven J
IR  - Berg J
FIR - Berg, Jessica
IR  - Baker A
FIR - Baker, Alison
EDAT- 2012/10/31 06:00
MHDA- 2013/01/08 06:00
CRDT- 2012/10/31 06:00
PHST- 2012/10/31 06:00 [entrez]
PHST- 2012/10/31 06:00 [pubmed]
PHST- 2013/01/08 06:00 [medline]
AID - peds.2012-2482 [pii]
AID - 10.1542/peds.2012-2482 [doi]
PST - ppublish
SO  - Pediatrics. 2012 Nov;130(5):972-7. doi: 10.1542/peds.2012-2482. Epub 2012 Oct 29.


PMID- 23109513
OWN - NLM
STAT- MEDLINE
DCOM- 20130108
LR  - 20140325
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 11
DP  - 2012 Nov
TI  - Freedom of movement across the EU: legal and ethical issues for children with
      chronic disease.
PG  - 694-6
LID - 10.1136/medethics-2012-041475 [doi]
AB  - While freedom of movement has been one of the most highly respected human right
      across the EU, there are various aspects which come into play which still need to
      be resolved for this to be achieved in practice. One of these key issues is cross
      border health care. Indeed, there is an increasing awareness of standardisation
      of health service provision and cross border collaboration in the EU. However,
      certain groups particularly children may be at risk of suboptimal treatment as a 
      result. We present the case of a child patient which highlights the complexity of
      this matter spanning family law, health law, social security law as well as
      ethical issues. EU legislation needs to ensure that children patients have access
      to high quality care across the EU borders.
FAU - Mercieca, Cecilia
AU  - Mercieca C
AD  - Department of Rheumatology, Mater Dei Hospital, Malta.
FAU - Aquilina, Kevin
AU  - Aquilina K
FAU - Pullicino, Richard
AU  - Pullicino R
FAU - Borg, Andrew A
AU  - Borg AA
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Antirheumatic Agents)
RN  - 0 (Biological Products)
RN  - YL5FZ2Y5U1 (Methotrexate)
SB  - IM
MH  - Adrenal Cortex Hormones/administration & dosage
MH  - *Antirheumatic Agents/administration & dosage/economics
MH  - *Arthritis, Juvenile/drug therapy/economics
MH  - Biological Products/administration & dosage
MH  - Child
MH  - *Chronic Disease/therapy
MH  - Continuity of Patient Care
MH  - Delivery of Health Care/*ethics/*legislation & jurisprudence/standards
MH  - *European Union
MH  - Female
MH  - *Freedom
MH  - Humans
MH  - Insurance, Health
MH  - Interdisciplinary Communication
MH  - International Cooperation
MH  - Malta
MH  - *Medically Uninsured
MH  - Methotrexate/administration & dosage
MH  - *Patient Rights
EDAT- 2012/10/31 06:00
MHDA- 2013/01/09 06:00
CRDT- 2012/10/31 06:00
PHST- 2012/10/31 06:00 [entrez]
PHST- 2012/10/31 06:00 [pubmed]
PHST- 2013/01/09 06:00 [medline]
AID - medethics-2012-041475 [pii]
AID - 10.1136/medethics-2012-041475 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Nov;38(11):694-6. doi: 10.1136/medethics-2012-041475.


PMID- 23109280
OWN - NLM
STAT- MEDLINE
DCOM- 20130612
LR  - 20220408
IS  - 1520-6300 (Electronic)
IS  - 1042-0533 (Linking)
VI  - 25
IP  - 1
DP  - 2013 Jan-Feb
TI  - Field and laboratory methods in human milk research.
PG  - 1-11
LID - 10.1002/ajhb.22334 [doi]
AB  - Human milk is a complex and variable fluid of increasing interest to human
      biologists who study nutrition and health. The collection and analysis of human
      milk poses many practical and ethical challenges to field workers, who must
      balance both appropriate methodology with the needs of participating mothers and 
      infants and logistical challenges to collection and analysis. In this review, we 
      address various collection methods, volume measurements, and ethical
      considerations and make recommendations for field researchers. We also review
      frequently used methods for the analysis of fat, protein, sugars/lactose, and
      specific biomarkers in human milk. Finally, we address new technologies in human 
      milk research, the MIRIS Human Milk Analyzer and dried milk spots, which will
      improve the ability of human biologists and anthropologists to study human milk
      in field settings.
CI  - Copyright (c) 2012 Wiley Periodicals, Inc.
FAU - Miller, Elizabeth M
AU  - Miller EM
AD  - Department of Anthropology, University of South Florida, Tampa, Florida 33620,
      USA. emm3@usf.edu
FAU - Aiello, Marco O
AU  - Aiello MO
FAU - Fujita, Masako
AU  - Fujita M
FAU - Hinde, Katie
AU  - Hinde K
FAU - Milligan, Lauren
AU  - Milligan L
FAU - Quinn, E A
AU  - Quinn EA
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20121029
PL  - United States
TA  - Am J Hum Biol
JT  - American journal of human biology : the official journal of the Human Biology
      Council
JID - 8915029
RN  - 0 (Fats)
RN  - 0 (Proteins)
RN  - J2B2A4N98G (Lactose)
SB  - IM
EIN - Am J Hum Biol. 2013 May-Jun;25(3):442
MH  - Fats/analysis
MH  - Food Analysis/methods
MH  - Humans
MH  - Lactation
MH  - Lactose/analysis
MH  - Milk, Human/*chemistry
MH  - Proteins/analysis
MH  - Specimen Handling/ethics/*methods
EDAT- 2012/10/31 06:00
MHDA- 2013/06/13 06:00
CRDT- 2012/10/31 06:00
PHST- 2012/03/01 00:00 [received]
PHST- 2012/07/26 00:00 [revised]
PHST- 2012/09/25 00:00 [accepted]
PHST- 2012/10/31 06:00 [entrez]
PHST- 2012/10/31 06:00 [pubmed]
PHST- 2013/06/13 06:00 [medline]
AID - 10.1002/ajhb.22334 [doi]
PST - ppublish
SO  - Am J Hum Biol. 2013 Jan-Feb;25(1):1-11. doi: 10.1002/ajhb.22334. Epub 2012 Oct
      29.


PMID- 23109132
OWN - NLM
STAT- MEDLINE
DCOM- 20130424
LR  - 20211021
IS  - 1097-0274 (Electronic)
IS  - 0271-3586 (Linking)
VI  - 55
IP  - 12
DP  - 2012 Dec
TI  - International environmental and occupational health: From individual scientists
      to networked science Hubs.
PG  - 1069-77
LID - 10.1002/ajim.22130 [doi]
AB  - For the past 16 years, the International Training and Research in Environmental
      and Occupational Health program (ITREOH) has supported projects that link U.S.
      academic scientists with scientists from low- and middle-income countries in
      diverse research and research training activities. Twenty-two projects of varied 
      duration have conducted training to enhance the research capabilities of
      scientists at 75 institutions in 43 countries in Asia, Africa, Eastern Europe,
      and Latin America, and have built productive research relationships between these
      scientists and their U.S. partners. ITREOH investigators and their trainees have 
      produced publications that have advanced basic sciences, developed methods,
      informed policy outcomes, and built institutional capacity. Today, the changing
      nature of the health sciences calls for a more strategic approach. Data-rich team
      science requires greater capacity for information technology and knowledge
      synthesis at the local institution. More robust systems for ethical review and
      administrative support are necessary to advance population-based research.
      Sustainability of institutional research capability depends on linkages to
      multiple national and international partners. In this context, the Fogarty
      International Center, the National Institute of Environmental Sciences and the
      National Institute for Occupational Safety and Health, have reengineered the
      ITREOH program to support and catalyze a multi-national network of regional hubs 
      for Global Environmental and Occupational Health Sciences (GEOHealth). We
      anticipate that these networked science hubs will build upon previous investments
      by the ITREOH program and will serve to advance locally and internationally
      important health science, train and attract first-class scientists, and provide
      critical evidence to guide policy discussions.
CI  - Published in 2012. This article is a U.S. Government work and is in the public
      domain in the USA.
FAU - Rosenthal, Joshua
AU  - Rosenthal J
AD  - Fogarty International Center, Bethesda, Maryland, USA. joshua.rosenthal@nih.gov
FAU - Jessup, Christine
AU  - Jessup C
FAU - Felknor, Sarah
AU  - Felknor S
FAU - Humble, Michael
AU  - Humble M
FAU - Bader, Farah
AU  - Bader F
FAU - Bridbord, Kenneth
AU  - Bridbord K
LA  - eng
GR  - CC999999/Intramural CDC HHS/United States
GR  - Z99 TW999999/Intramural NIH HHS/United States
PT  - Historical Article
PT  - Journal Article
DEP - 20121025
PL  - United States
TA  - Am J Ind Med
JT  - American journal of industrial medicine
JID - 8101110
SB  - IM
MH  - Cost of Illness
MH  - Environmental Health/education/*history/organization & administration
MH  - Global Health/education/*history
MH  - History, 20th Century
MH  - History, 21st Century
MH  - International Cooperation
MH  - Occupational Health/education/history
MH  - Occupational Medicine/education/*history/organization & administration
MH  - Policy Making
MH  - United States
PMC - PMC3690551
MID - NIHMS476446
EDAT- 2012/10/31 06:00
MHDA- 2013/04/25 06:00
CRDT- 2012/10/31 06:00
PHST- 2012/09/25 00:00 [accepted]
PHST- 2012/10/31 06:00 [entrez]
PHST- 2012/10/31 06:00 [pubmed]
PHST- 2013/04/25 06:00 [medline]
AID - 10.1002/ajim.22130 [doi]
PST - ppublish
SO  - Am J Ind Med. 2012 Dec;55(12):1069-77. doi: 10.1002/ajim.22130. Epub 2012 Oct 25.


PMID- 23109075
OWN - NLM
STAT- MEDLINE
DCOM- 20131212
LR  - 20131029
IS  - 1090-3941 (Print)
IS  - 1090-3941 (Linking)
VI  - 22
DP  - 2012 Dec
TI  - New surgical technique for treatment of stress urinary incontinence TVT-ABBREVO
      from development to clinical experience.
PG  - 149-57
AB  - Tension-free suburethral tapes have revolutionized the surgical treatment of
      female stress urinary incontinence (SUI). These tapes are inserted by way of a
      retropubic or transobturator route. The inside-out tension-free vaginal tape
      transobturator approach, or TVT-Obturator system (TVT-O, Ethicon Women's Health
      and Urology, Somerville, NJ), was developed ten years ago with the aim of
      minimizing the risk of urinary tract injuries associated with retropubic and
      outside-in transobturator tapes while reproducibly ensuring minimal tissue
      dissection. Cadaveric studies have shown that the anatomical trajectory of the
      TVT-O tape is strictly perineal and courses away from neighboring obturator and
      pudendal neurovascular structures. Several meta-analyses have shown similar SUI
      cure rates after retropubic and transobturator tape procedures. Yet, the
      transobturator route may be associated with less voiding dysfunction, blood loss,
      bladder perforation, and shorter operating time. The original TVT-O procedure was
      modified with the aim of reducing the incidence of postoperative groin pain as
      well as the rather theoretical risk of obturator nerve injury. This modified
      procedure, named TVT-ABBREVO (Ethicon Women's Health and Urology, Somerville,
      NJ), utilizes a shortened, 12-cm-long polypropylene tape. In addition,
      perforation of the obturator membrane with the scissors and guide is avoided in
      order to reduce the depth of lateral dissection, and consequently, to maximize
      securing of the tape within the obturator muscular/aponeurotic structures. In a
      comparative anatomical study, it was indeed observed that the shorter tape
      traversed less muscular structures (with no or only a minimal amount of tape
      lying in the adductor muscles) than its original counterpart, while still
      consistently anchoring in the obturator membrane at a similarly safe distance
      from the obturator canal. In a single-center randomized clinical trial, after a
      3-year minimum follow-up, the modified TVT-O procedure with a shorter tape and
      reduced dissection was found to be as safe and efficient as the primal procedure 
      for treating female SUI, with less severe and frequent groin pain in the
      immediate postoperative period.
FAU - Waltregny, David
AU  - Waltregny D
AD  - Department of Urology, University Hospital of Liege, Liege, Belgium.
FAU - de Leval, Jean
AU  - de Leval J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Surg Technol Int
JT  - Surgical technology international
JID - 9604509
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Equipment Design
MH  - Evidence-Based Medicine
MH  - Female
MH  - Gynecologic Surgical Procedures/*instrumentation/*methods
MH  - Humans
MH  - Middle Aged
MH  - *Suburethral Slings
MH  - *Surgical Tape
MH  - Treatment Outcome
MH  - Urinary Incontinence, Stress/*surgery
MH  - Young Adult
EDAT- 2012/10/31 06:00
MHDA- 2013/12/18 06:00
CRDT- 2012/10/31 06:00
PHST- 2012/10/31 06:00 [entrez]
PHST- 2012/10/31 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
AID - sti22/23 [pii]
PST - ppublish
SO  - Surg Technol Int. 2012 Dec;22:149-57.


PMID- 23108507
OWN - NLM
STAT- MEDLINE
DCOM- 20130529
LR  - 20211021
IS  - 1573-3572 (Electronic)
IS  - 1068-9583 (Linking)
VI  - 19
IP  - 4
DP  - 2012 Dec
TI  - Balancing confidentiality and collaboration within multidisciplinary health care 
      teams.
PG  - 411-7
LID - 10.1007/s10880-012-9333-0 [doi]
AB  - As multidisciplinary perspectives are increasingly integrated into the treatment 
      of health problems, opportunities for clinical psychologists in medical settings 
      are expanding. Although cross-discipline collaboration is at the core of
      multidisciplinary treatment models, psychologists must be particularly cautious
      about information sharing due to their profession's ethical standards regarding
      patient confidentiality. Psychologists' ethical obligations require them to
      achieve a delicate balance between contributing to the treatment team and
      protecting patient confidentiality. In the current review, relevant ethical
      standards and federal guidelines are applied to everyday practices of clinical
      psychologists in medical settings. Additionally, recommendations for individual
      psychologists, health care organizations, and graduate training programs are
      presented.
FAU - Van Liew, Julia R
AU  - Van Liew JR
AD  - Department of Psychology, The University of Iowa, E11 Seashore Hall, Iowa City,
      IA, 52242, USA. julia-vanliew@uiowa.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Psychol Med Settings
JT  - Journal of clinical psychology in medical settings
JID - 9435680
SB  - IM
MH  - *Confidentiality/ethics/legislation & jurisprudence
MH  - *Electronic Health Records/ethics/legislation & jurisprudence
MH  - Health Insurance Portability and Accountability Act
MH  - Humans
MH  - Inservice Training
MH  - *Interprofessional Relations/ethics
MH  - Mental Disorders/*therapy
MH  - Patient Care Team
MH  - Practice Guidelines as Topic
MH  - Societies, Scientific
MH  - United States
EDAT- 2012/10/31 06:00
MHDA- 2013/05/31 06:00
CRDT- 2012/10/31 06:00
PHST- 2012/10/31 06:00 [entrez]
PHST- 2012/10/31 06:00 [pubmed]
PHST- 2013/05/31 06:00 [medline]
AID - 10.1007/s10880-012-9333-0 [doi]
PST - ppublish
SO  - J Clin Psychol Med Settings. 2012 Dec;19(4):411-7. doi:
      10.1007/s10880-012-9333-0.


PMID- 23108361
OWN - NLM
STAT- MEDLINE
DCOM- 20130819
LR  - 20211021
IS  - 2164-554X (Electronic)
IS  - 2164-5515 (Linking)
VI  - 9
IP  - 1
DP  - 2013 Jan
TI  - Nicotine vaccines to treat tobacco dependence.
PG  - 13-25
LID - 10.4161/hv.22060 [doi]
AB  - Tobacco smoking is globally far more widespread than use of any other substance
      of abuse. Nicotine is an important tobacco constituent that is responsible for
      addictive properties of smoking. The currently available medications for the
      treatment of nicotine addiction have limited efficacy. A challenging novel
      therapeutic concept is vaccination against nicotine. An efficient vaccine would
      generate antibodies that sequester nicotine in the blood and prevent its access
      to the brain. The vaccine would have great potential for treating nicotine
      addiction and for relapse prevention. We reviewed the current status of vaccines 
      against nicotine addiction that are undergoing clinical trials or are in
      preclinical development. We discuss problems associated with the development of
      nicotine vaccines, their efficacy in addiction treatment, challenges and ethical 
      concerns. Existing evidence indicates that nicotine vaccination is well tolerated
      and capable of inducing an immune response but its effectiveness in increasing
      smoking abstinence has not been shown so far.
FAU - Goniewicz, Maciej L
AU  - Goniewicz ML
AD  - Tobacco Dependence Research Unit, Wolfson Institute of Preventive Medicine, Queen
      Mary University of London, London, UK. m.goniewicz@qmul.ac.uk
FAU - Delijewski, Marcin
AU  - Delijewski M
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121029
PL  - United States
TA  - Hum Vaccin Immunother
JT  - Human vaccines & immunotherapeutics
JID - 101572652
RN  - 0 (Vaccines)
RN  - 6M3C89ZY6R (Nicotine)
SB  - IM
MH  - Humans
MH  - Nicotine/*antagonists & inhibitors
MH  - Tobacco Use Disorder/*therapy
MH  - Treatment Outcome
MH  - Vaccination/*methods
MH  - Vaccines/*therapeutic use
PMC - PMC3667928
OTO - NOTNLM
OT  - cigarette smoking
OT  - dopamine
OT  - drugs of abuse
OT  - nicotine
OT  - nicotine addiction
OT  - relapse prevention
OT  - smoking cessation
OT  - vaccines
EDAT- 2012/10/31 06:00
MHDA- 2013/08/21 06:00
CRDT- 2012/10/31 06:00
PHST- 2012/10/31 06:00 [entrez]
PHST- 2012/10/31 06:00 [pubmed]
PHST- 2013/08/21 06:00 [medline]
AID - 22060 [pii]
AID - 10.4161/hv.22060 [doi]
PST - ppublish
SO  - Hum Vaccin Immunother. 2013 Jan;9(1):13-25. doi: 10.4161/hv.22060. Epub 2012 Oct 
      29.


PMID- 23107356
OWN - NLM
STAT- MEDLINE
DCOM- 20130715
LR  - 20130215
IS  - 1879-1409 (Electronic)
IS  - 0305-4179 (Linking)
VI  - 39
IP  - 2
DP  - 2013 Mar
TI  - Mortality after treating severe burns with traditional Amish home remedies: a
      case report, literature review and ethical discussion.
PG  - e13-6
LID - 10.1016/j.burns.2012.09.011 [doi]
LID - S0305-4179(12)00300-2 [pii]
FAU - Kahn, Steven A
AU  - Kahn SA
AD  - Department of Surgery, University of Rochester Medical Center, Rochester, NY
      14642, USA. Steven_Kahn@urmc.rochester.edu
FAU - Demme, Richard A
AU  - Demme RA
FAU - Lentz, Christopher W
AU  - Lentz CW
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20121026
PL  - Netherlands
TA  - Burns
JT  - Burns : journal of the International Society for Burn Injuries
JID - 8913178
RN  - 0 (Plant Preparations)
SB  - IM
MH  - Adult
MH  - *Amish
MH  - Burns/*drug therapy
MH  - Complementary Therapies/*ethics
MH  - Fatal Outcome
MH  - Humans
MH  - Informed Consent/ethics
MH  - Male
MH  - *Medicine, Traditional/methods
MH  - Plant Preparations/*therapeutic use
MH  - Religion and Medicine
MH  - Treatment Refusal/*ethics
EDAT- 2012/10/31 06:00
MHDA- 2013/07/17 06:00
CRDT- 2012/10/31 06:00
PHST- 2012/03/29 00:00 [received]
PHST- 2012/09/08 00:00 [accepted]
PHST- 2012/10/31 06:00 [entrez]
PHST- 2012/10/31 06:00 [pubmed]
PHST- 2013/07/17 06:00 [medline]
AID - S0305-4179(12)00300-2 [pii]
AID - 10.1016/j.burns.2012.09.011 [doi]
PST - ppublish
SO  - Burns. 2013 Mar;39(2):e13-6. doi: 10.1016/j.burns.2012.09.011. Epub 2012 Oct 26.


PMID- 23107123
OWN - NLM
STAT- MEDLINE
DCOM- 20150915
LR  - 20220310
IS  - 1466-609X (Electronic)
IS  - 1364-8535 (Linking)
VI  - 16
IP  - 5
DP  - 2012 Oct 29
TI  - Medical emergency teams are associated with reduced mortality across a major
      metropolitan health network after two years service: a retrospective study using 
      government administrative data.
PG  - R210
LID - 10.1186/cc11843 [doi]
AB  - INTRODUCTION: Medical emergency teams (MET) are implemented to ensure prompt
      clinical review of patients with deteriorating physiology with the intention of
      averting further deterioration, cardiac arrest and death. We sought to determine 
      if MET implementation has led to reductions in hospital mortality across a large 
      metropolitan health network utilising routine administrative data submitted by
      hospitals to the Department of Health Victoria. METHODS: The Victorian admissions
      episodes data set (VAED) contains data on all individual hospital separations in 
      the State of Victoria, Australia. After gaining institutional ethics approval, we
      extracted data on all acute admissions to metropolitan hospitals for which we had
      information on the presence and timing of a MET system. Using logistic regression
      we determined whether there was an effect of MET implementation on mortality
      controlling for age, gender, Charlson comorbidity diagnostic groupings, emergency
      admission, same day admission, ICU admission, mechanical ventilation, year,
      indigenous ethnicity, liaison nurse service and hospital designation. RESULTS:
      5911533 individual admissions and 73,599 associated deaths from July 1999 to June
      2010 were included in the analysis. 52.2% were male and median age was 57(42-72
      IQR). Mortality rates for MET and non-MET periods were 3.92 (3.88-3.95 95%CI) and
      4.56 (4.51-4.61 95%CI) deaths per 1000 patient days with a rate ratio after
      adjustment for year of 0.88 (0.86-0.89 95%CI) P < 0.001. In a multivariable
      logistic regression, mortality was associated with a MET team being active in the
      hospital for more than 2 years. The odds ratio for mortality in hospitals where a
      MET system had been in place for greater than 4 years duration was 0.90
      (0.88-0.92). Mortality during the first 2 years of a MET system being in place
      was not statistically different from pre-MET periods. CONCLUSIONS: Utilising
      routinely collected administrative data we demonstrated that the presence of a
      hospital MET system for greater than 2 years was associated with an independent
      reduction in hospital mortality across a major metropolitan health network.
      Mortality benefits after the introduction of a MET system take time to become
      apparent.
FAU - Tobin, Antony E
AU  - Tobin AE
FAU - Santamaria, John D
AU  - Santamaria JD
LA  - eng
PT  - Journal Article
DEP - 20121029
PL  - England
TA  - Crit Care
JT  - Critical care (London, England)
JID - 9801902
SB  - IM
MH  - Adult
MH  - Aged
MH  - Australia/epidemiology
MH  - Emergency Service, Hospital/*organization & administration
MH  - Female
MH  - Hospital Mortality/*trends
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Patient Care Team
MH  - Retrospective Studies
MH  - Urban Population
PMC - PMC3682314
EDAT- 2012/10/31 06:00
MHDA- 2015/09/16 06:00
CRDT- 2012/10/31 06:00
PHST- 2012/08/02 00:00 [received]
PHST- 2012/10/23 00:00 [accepted]
PHST- 2012/10/31 06:00 [entrez]
PHST- 2012/10/31 06:00 [pubmed]
PHST- 2015/09/16 06:00 [medline]
AID - cc11843 [pii]
AID - 10.1186/cc11843 [doi]
PST - epublish
SO  - Crit Care. 2012 Oct 29;16(5):R210. doi: 10.1186/cc11843.


PMID- 23107083
OWN - NLM
STAT- MEDLINE
DCOM- 20130122
LR  - 20220331
IS  - 1097-6868 (Electronic)
IS  - 0002-9378 (Linking)
VI  - 207
IP  - 5
DP  - 2012 Nov
TI  - An educational workshop and student competency in pregnancy options counseling: a
      randomized controlled trial.
PG  - 414.e1-7
LID - 10.1016/j.ajog.2012.09.026 [doi]
LID - S0002-9378(12)01067-8 [pii]
AB  - OBJECTIVE: We sought to determine the effect of a pregnancy options counseling
      workshop focusing on communication skills and ethics on medical student
      competency. STUDY DESIGN: This educational trial randomized 105 third-year
      students to performance of an objective structured clinical examination before or
      after participation in the workshop assessed by a blinded reviewer. The primary
      outcome variable was student-level global competency in options counseling;
      secondary outcomes included competency components of general communication.
      RESULTS: Global competency was achieved by 36% of students in the preworkshop
      group and 50% in the postworkshop group (P = .16). Students who participated in
      the workshop demonstrated higher communication skills. Student ratings of
      objective structured clinical examination quality were 96-100% positive, with 80%
      reporting an increase in comfort with options counseling and 88% reporting
      increased comfort with communication skills. CONCLUSION: Participation in a
      workshop focusing on conscientious refusal positively improved communication
      skills, but did not significantly impact students' competency in pregnancy
      options counseling.
CI  - Copyright (c) 2012 Mosby, Inc. All rights reserved.
FAU - Lupi, Carla S
AU  - Lupi CS
AD  - Department of Obstetrics and Gynecology, Herbert Wertheim College of Medicine,
      Florida International University, Miami, FL, USA.
FAU - Runyan, Aliye
AU  - Runyan A
FAU - Schreiber, Nicolette
AU  - Schreiber N
FAU - Steinauer, Jody
AU  - Steinauer J
FAU - Turk, Jema K
AU  - Turk JK
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20120927
PL  - United States
TA  - Am J Obstet Gynecol
JT  - American journal of obstetrics and gynecology
JID - 0370476
SB  - IM
MH  - *Clinical Competence
MH  - Counseling/*education
MH  - *Education
MH  - Education, Medical/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Physician-Patient Relations
MH  - Pregnancy
EDAT- 2012/10/31 06:00
MHDA- 2013/01/23 06:00
CRDT- 2012/10/31 06:00
PHST- 2012/05/09 00:00 [received]
PHST- 2012/08/13 00:00 [revised]
PHST- 2012/09/24 00:00 [accepted]
PHST- 2012/10/31 06:00 [entrez]
PHST- 2012/10/31 06:00 [pubmed]
PHST- 2013/01/23 06:00 [medline]
AID - S0002-9378(12)01067-8 [pii]
AID - 10.1016/j.ajog.2012.09.026 [doi]
PST - ppublish
SO  - Am J Obstet Gynecol. 2012 Nov;207(5):414.e1-7. doi: 10.1016/j.ajog.2012.09.026.
      Epub 2012 Sep 27.


PMID- 23106906
OWN - NLM
STAT- MEDLINE
DCOM- 20130826
LR  - 20220318
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 161
IP  - 3
DP  - 2012 Nov 29
TI  - Adherence to ethical standards in publishing scientific articles: a statement
      from the International Journal of Cardiology.
PG  - 124-5
LID - 10.1016/j.ijcard.2012.10.021 [doi]
LID - S0167-5273(12)01396-4 [pii]
AB  - All authors of manuscripts in the International Journal of Cardiology are
      required to make a binding statement that they as authors adhere to the following
      principles: 1. That the corresponding author has the approval of all other listed
      authors for the submission and publication of all versions of the manuscript. 2. 
      That all people who have the right to be recognised as authors have been included
      on the list of authors and everyone listed as an author has made an independent
      material contribution to the manuscript. 3. That the work submitted in the
      manuscript is original and has not been published elsewhere and is not presently 
      under consideration of publication by any other journal other than in oral,
      poster or abstract format. 4. That the material in the manuscript has been
      acquired according to modern ethical standards and has been approved by the
      legally appropriate ethical committee. 5. That the article does not contain
      material copied from anyone else without their written permission and that all
      material which derives from prior work, including from the same authors, is
      properly attributed to the prior publication by proper citation. 6. That all
      material conflicts of interest have been declared including the use of paid
      medical writers and their funding source. 7. That the manuscript will be
      maintained on the servers of the journal and held to be a valid publication by
      the journal only as long as all statements in these principles remain true. 8.
      That if any of the statements above ceases to be true the authors have a duty to 
      notify the journal as soon as possible so that the manuscript can be withdrawn.
CI  - Copyright (c) 2012. Published by Elsevier Ireland Ltd.
FAU - Shewan, Louise G
AU  - Shewan LG
FAU - Coats, Andrew J S
AU  - Coats AJ
LA  - eng
PT  - Editorial
DEP - 20121027
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
SB  - IM
MH  - Authorship/standards
MH  - Cardiology/*ethics/*standards
MH  - Conflict of Interest
MH  - Humans
MH  - Internationality
MH  - Periodicals as Topic/ethics/standards
MH  - Publishing/*ethics/*standards
EDAT- 2012/10/31 06:00
MHDA- 2013/08/27 06:00
CRDT- 2012/10/31 06:00
PHST- 2012/10/13 00:00 [received]
PHST- 2012/10/13 00:00 [accepted]
PHST- 2012/10/31 06:00 [entrez]
PHST- 2012/10/31 06:00 [pubmed]
PHST- 2013/08/27 06:00 [medline]
AID - S0167-5273(12)01396-4 [pii]
AID - 10.1016/j.ijcard.2012.10.021 [doi]
PST - ppublish
SO  - Int J Cardiol. 2012 Nov 29;161(3):124-5. doi: 10.1016/j.ijcard.2012.10.021. Epub 
      2012 Oct 27.


PMID- 23106806
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130320
LR  - 20211021
IS  - 1472-6955 (Electronic)
IS  - 1472-6955 (Linking)
VI  - 11
DP  - 2012 Oct 29
TI  - Primary health care nurses' knowledge practice and client teaching of early
      detection measures of breast cancer in Ibadan.
PG  - 22
LID - 10.1186/1472-6955-11-22 [doi]
AB  - BACKGROUND: Early detection of breast cancer is vital to effective management and
      outcome of breast cancer. It has been suggested that women given information and 
      instruction about breast self- examination and breast awareness by health care
      professionals demonstrated higher knowledge and confidence and tend to practice
      breast self-examination more than those who received information from other
      sources. Breast Self-Examination (BSE) and Clinical Breast Examination (CBE) have
      been recommended as Early Detection Measures (EDM) for developing countries. This
      study evaluated Primary Health Care (PHC) nurses' knowledge, practice and client 
      teaching of EDM of breast cancer. METHODS: A descriptive study that utilized
      stratified random method to select PHC settings for the study. Data was collected
      from 120 trained nurses in selected settings. This represented 66.3% of total
      population of PHC nurses (181) in Ibadan. The instrument for data collection was 
      a structured questionnaire that explored the bio data of participants, knowledge,
      practice and client teaching of EDMs of breast cancer. Ethical approval was
      obtained from the Ethical Review Committee of Oyo State Ministry of Health,
      Nigeria. RESULTS: The mean age of the participants was 44.4+/-7.5 years. About
      half (52.2%) were double qualified (Registered Nurse and Midwife). Only 23
      (20.0%) of the participants considered painless lump as an early sign of breast
      cancer while 47 (40.9%) considered pain as an early sign. BSE was listed as EDM
      of breast cancer by 80.9% of the participants while 40% and 30% listed CBE and
      mammogram respectively. Only eight (7.9%) have had a mammogram. The logistic
      regression of client teaching on four variables showed that for every increase in
      knowledge of breast cancer the odds of client teaching significantly increased by
      7.5% (95% CI = 1.27 - 1.125). There were also significant relationships between
      knowledge of EDM, practice of BSE and client teaching. CONCLUSIONS: It is vital
      that attention should be given to enhance breast cancer EDMs among the PHC nurses
      to be able to enhance health deviation self-care of the clients. Nurses'
      knowledge, practice as well as client teaching especially at PHC level, will
      contribute to early detection of breast cancer.
FAU - Oluwatosin, Oabimbola
AU  - Oluwatosin O
AD  - Department of Nursing, Faculty of Clinical Sciences, College of Medicine,
      University of Ibadan, Ibadan, Oyo State, Nigeria. aoluwatosin@yahoo.com.
LA  - eng
PT  - Journal Article
DEP - 20121029
PL  - England
TA  - BMC Nurs
JT  - BMC nursing
JID - 101088683
PMC - PMC3601001
EDAT- 2012/10/31 06:00
MHDA- 2012/10/31 06:01
CRDT- 2012/10/31 06:00
PHST- 2012/04/30 00:00 [received]
PHST- 2012/10/24 00:00 [accepted]
PHST- 2012/10/31 06:00 [entrez]
PHST- 2012/10/31 06:00 [pubmed]
PHST- 2012/10/31 06:01 [medline]
AID - 1472-6955-11-22 [pii]
AID - 10.1186/1472-6955-11-22 [doi]
PST - epublish
SO  - BMC Nurs. 2012 Oct 29;11:22. doi: 10.1186/1472-6955-11-22.


PMID- 23106755
OWN - NLM
STAT- MEDLINE
DCOM- 20130418
LR  - 20121030
IS  - 1365-2788 (Electronic)
IS  - 0964-2633 (Linking)
VI  - 56
IP  - 11
DP  - 2012 Nov
TI  - The human rights context for ethical requirements for involving people with
      intellectual disability in medical research.
PG  - 1122-32
LID - 10.1111/j.1365-2788.2012.01617.x [doi]
AB  - BACKGROUND: The history of ethical guidelines addresses protection of human
      rights in the face of violations. Examples of such violations in research
      involving people with intellectual disabilities (ID) abound. We explore this
      history in an effort to understand the apparently stringent criteria for the
      inclusion of people with ID in research, and differences between medical and
      other research within a single jurisdiction. METHOD: The history of the Helsinki 
      Declaration and informed consent within medical research, and high-profile
      examples of ethical misconduct involving people with ID and other groups are
      reviewed. The UN Convention on the Rights of Persons with Disabilities is then
      examined for its research implications. This background is used to examine a
      current anomaly within an Australian context for the inclusion of people with ID 
      without decisional capacity in medical versus other types of research. RESULTS:
      Ethical guidelines have often failed to protect the human rights of people with
      ID and other vulnerable groups. Contrasting requirements within an Australian
      jurisdiction for medical and other research would seem to have originated in
      early deference to medical authority for making decisions on behalf of patients. 
      CONCLUSIONS: Stringent ethical requirements are likely to continue to challenge
      researchers in ID. A human rights perspective provides a framework for engaging
      both researchers and vulnerable participant groups.
CI  - (c) 2012 The Authors. Journal of Intellectual Disability Research (c) 2012
      Blackwell Publishing Ltd.
FAU - Iacono, T
AU  - Iacono T
AD  - La Trobe Rural Health School, La Trobe University, Bendigo, Victoria, Australia. 
      t.iacono@latrobe.edu.au
FAU - Carling-Jenkins, R
AU  - Carling-Jenkins R
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - England
TA  - J Intellect Disabil Res
JT  - Journal of intellectual disability research : JIDR
JID - 9206090
SB  - IM
MH  - Australia
MH  - Biomedical Research/ethics/*history
MH  - Disabled Persons/history
MH  - Ethics, Medical/*history
MH  - Guidelines as Topic
MH  - Helsinki Declaration/history
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Human Experimentation/ethics/*history
MH  - Human Rights/*history
MH  - Informed Consent/history
MH  - Intellectual Disability/*history
MH  - National Socialism/history
MH  - United Nations/history
EDAT- 2012/10/31 06:00
MHDA- 2013/04/20 06:00
CRDT- 2012/10/31 06:00
PHST- 2012/10/31 06:00 [entrez]
PHST- 2012/10/31 06:00 [pubmed]
PHST- 2013/04/20 06:00 [medline]
AID - 10.1111/j.1365-2788.2012.01617.x [doi]
PST - ppublish
SO  - J Intellect Disabil Res. 2012 Nov;56(11):1122-32. doi:
      10.1111/j.1365-2788.2012.01617.x.


PMID- 23106687
OWN - NLM
STAT- MEDLINE
DCOM- 20141114
LR  - 20161125
IS  - 2044-8309 (Electronic)
IS  - 0144-6665 (Linking)
VI  - 53
IP  - 1
DP  - 2014 Mar
TI  - Ethics in action: consent-gaining interactions and implications for research
      practice.
PG  - 54-73
LID - 10.1111/bjso.12009 [doi]
AB  - This article deals with the topic of social psychological research methods in
      practice, by examining how informed consent is gained from research participants.
      In most research, the consent-gaining process is hidden from analytic scrutiny
      and is dealt with before data collection has begun. In contrast, conversation
      analytic research, which records interactional encounters from beginning to end, 
      enables examination of this methodological 'black box'. We explored how
      'requests' to consent in research played out across different institutional
      settings. We found that participants had to 'opt-out' of a research process that 
      was already underway. Consent-gaining sequences constrained opting out in two
      ways: (1) because research activity was already underway, it must be stopped
      affirmatively by participants; (2) consent-gaining turns were tilted in favour of
      continued participation, making opting out a dispreferred response. We also found
      a mismatch between what ethics guidelines specify about consent-gaining 'in
      theory' and what actually happens 'in practice'. Finally, we make suggestions
      about interventions in and recommendations for existing practice to best achieve 
      informed consent.
CI  - (c) 2012 The British Psychological Society.
FAU - Speer, Susan A
AU  - Speer SA
AD  - School of Psychological Sciences (Psychology Division), University of Manchester,
      UK.
FAU - Stokoe, Elizabeth
AU  - Stokoe E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121029
PL  - England
TA  - Br J Soc Psychol
JT  - The British journal of social psychology
JID - 8105534
SB  - IM
MH  - *Communication
MH  - *Ethics, Research
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Psychology, Social/*ethics
MH  - United Kingdom
EDAT- 2012/10/31 06:00
MHDA- 2014/11/15 06:00
CRDT- 2012/10/31 06:00
PHST- 2012/03/16 00:00 [received]
PHST- 2012/08/03 00:00 [revised]
PHST- 2012/10/31 06:00 [entrez]
PHST- 2012/10/31 06:00 [pubmed]
PHST- 2014/11/15 06:00 [medline]
AID - 10.1111/bjso.12009 [doi]
PST - ppublish
SO  - Br J Soc Psychol. 2014 Mar;53(1):54-73. doi: 10.1111/bjso.12009. Epub 2012 Oct
      29.


PMID- 23106657
OWN - NLM
STAT- MEDLINE
DCOM- 20130412
LR  - 20121030
IS  - 1365-2222 (Electronic)
IS  - 0954-7894 (Linking)
VI  - 42
IP  - 11
DP  - 2012 Nov
TI  - Adherence in severe asthma.
PG  - 1566-74
LID - 10.1111/j.1365-2222.2012.04018.x [doi]
AB  - Adherence in asthma is an important cause for concern. Although nearly 50% of
      asthma patients are considered poorly adherent to therapeutic advices, adherence 
      is still difficult to assess, understand and improve despite major medical
      consequences. In this review, we revisited the literature of the last 10 years
      related to adherence in severe asthma. The concepts have changed and "compliance"
      is usually replaced by "adherence". Assessment of adherence is addressing ethical
      issues, but provides important insight into difficult-to-treat asthma. Different 
      tools have been used but none is routinely recommended. Health-related outcomes
      (poor control, exacerbations, hospitalizations, lung function decline), which are
      clearly associated with severe asthma, are often worsened by non-adherence with
      consequences also on patient related outcomes (quality of life). The potential
      behaviour associated with non-adherence and all other related factors including
      easy-to-recognize psychological traits can help for patient's future management. 
      Therapeutic educational interventions have been recognized with a scientifically 
      proven efficiency even though evolution and improvements are needed. A
      multidisciplinary approach is required in severe asthma. Therapeutic adherence
      for a given patient is always a prerequisite to any other aspects when addressing
      severe asthma phenotypes. Severe asthma should be considered only in those who
      still experienced poor asthma outcomes despite optimal adherence. At a glance,
      poor adherence and severe asthma should be considered antinomic. Better
      understanding of the causes and customised management are potential future
      directions.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Bourdin, A
AU  - Bourdin A
AD  - Department of Respiratory Diseases, CHU Montpellier, and INSERM U1046, Universite
      Montpellier 1, Universite Montpellier 2, Montpellier, France.
      a-bourdin@chu-montpellier.fr
FAU - Halimi, L
AU  - Halimi L
FAU - Vachier, I
AU  - Vachier I
FAU - Paganin, F
AU  - Paganin F
FAU - Lamouroux, A
AU  - Lamouroux A
FAU - Gouitaa, M
AU  - Gouitaa M
FAU - Vairon, E
AU  - Vairon E
FAU - Godard, P
AU  - Godard P
FAU - Chanez, P
AU  - Chanez P
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Clin Exp Allergy
JT  - Clinical and experimental allergy : journal of the British Society for Allergy
      and Clinical Immunology
JID - 8906443
SB  - IM
MH  - Asthma/psychology/*therapy
MH  - Humans
MH  - Medication Adherence
MH  - *Patient Compliance
MH  - Risk Factors
EDAT- 2012/10/31 06:00
MHDA- 2013/04/13 06:00
CRDT- 2012/10/31 06:00
PHST- 2012/10/31 06:00 [entrez]
PHST- 2012/10/31 06:00 [pubmed]
PHST- 2013/04/13 06:00 [medline]
AID - 10.1111/j.1365-2222.2012.04018.x [doi]
PST - ppublish
SO  - Clin Exp Allergy. 2012 Nov;42(11):1566-74. doi: 10.1111/j.1365-2222.2012.04018.x.


PMID- 23106035
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220316
IS  - 2160-584X (Print)
VI  - 1
IP  - 1
DP  - 2012 Jan 1
TI  - Research on MI in Equipoise: The Case of Living Organ Donation.
PG  - 39-41
AB  - Residual ambivalence prior to live organ donation has been shown to predict worse
      physical and psychological outcomes for the donor following surgery. We are
      studying whether MI can help individuals who have agreed to become living organ
      donors to resolve residual ambivalence about their decision. In this situation,
      ethical practice demands that the counselor take up a stance of equipoise,
      equally welcoming of strengthened resolve to donate or a decision not to do so.
      This paper describes our adaptations of MI for this unique application.
FAU - Zuckoff, Allan
AU  - Zuckoff A
AD  - Departments of Psychology and Psychiatry, University of Pittsburgh.
FAU - Dew, Mary Amanda
AU  - Dew MA
LA  - eng
GR  - R21 NR011149/NR/NINR NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Motiv Interviewing
JT  - Motivational interviewing : training, research, implementation, practice
JID - 101565155
PMC - PMC3479674
MID - NIHMS384566
EDAT- 2012/10/30 06:00
MHDA- 2012/10/30 06:01
CRDT- 2012/10/30 06:00
PHST- 2012/10/30 06:00 [entrez]
PHST- 2012/10/30 06:00 [pubmed]
PHST- 2012/10/30 06:01 [medline]
AID - 10.5195/mitrip.2012.12 [doi]
PST - ppublish
SO  - Motiv Interviewing. 2012 Jan 1;1(1):39-41. doi: 10.5195/mitrip.2012.12.


PMID- 23104592
OWN - NLM
STAT- MEDLINE
DCOM- 20130703
LR  - 20130121
IS  - 2193-6323 (Electronic)
IS  - 2193-6315 (Linking)
VI  - 74
IP  - 1
DP  - 2013 Jan
TI  - Psychosurgery: review of latest concepts and applications.
PG  - 29-46
LID - 10.1055/s-0032-1304805 [doi]
AB  - Although the utilization of psychosurgery has commenced in early 19th century,
      when compared with other neurosurgical fields, it faced many obstacles resulting 
      in the delay of advancement of this type of surgical methodology. This was due to
      the insufficient knowledge of both neural networks of the brain and the
      pathophysiology of psychiatric diseases. The aggressive surgical treatment
      modalities with high mortality and morbidity rates, the controversial ethical
      concerns, and the introduction of antipsychotic drugs were also among those
      obstacles. With the recent advancements in the field of neuroscience more
      accurate knowledge was gained in this field offering new ideas for the management
      of these diseases. Also, the recent technological developments aided the surgeons
      to define more sophisticated and minimally invasive techniques during the
      surgical procedures. Maybe the most important factor in the rerising of
      psychosurgery is the assemblage of the experts, clinicians, and researchers in
      various fields of neurosciences implementing a multidisciplinary approach. In
      this article, the authors aim to review the latest concepts of the
      pathophysiology and the recent advancements of the surgical treatment of
      psychiatric diseases from a neurosurgical point of view.
CI  - Georg Thieme Verlag KG Stuttgart . New York.
FAU - Aydin, Sabri
AU  - Aydin S
AD  - Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University,
      Istanbul, Turkey.
FAU - Abuzayed, Bashar
AU  - Abuzayed B
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121026
PL  - Germany
TA  - J Neurol Surg A Cent Eur Neurosurg
JT  - Journal of neurological surgery. Part A, Central European neurosurgery
JID - 101580767
SB  - IM
MH  - Brain/*surgery
MH  - Humans
MH  - Mental Disorders/*surgery
MH  - Psychosurgery/*methods
EDAT- 2012/10/30 06:00
MHDA- 2013/07/05 06:00
CRDT- 2012/10/30 06:00
PHST- 2012/10/30 06:00 [entrez]
PHST- 2012/10/30 06:00 [pubmed]
PHST- 2013/07/05 06:00 [medline]
AID - 10.1055/s-0032-1304805 [doi]
PST - ppublish
SO  - J Neurol Surg A Cent Eur Neurosurg. 2013 Jan;74(1):29-46. doi:
      10.1055/s-0032-1304805. Epub 2012 Oct 26.


PMID- 23104549
OWN - NLM
STAT- MEDLINE
DCOM- 20131127
LR  - 20211021
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 24
IP  - 4
DP  - 2012 Dec
TI  - Medical professionalism, revenue enhancement, and self-interest: an ethically
      ambiguous association.
PG  - 307-15
LID - 10.1007/s10730-012-9198-5 [doi]
AB  - This article explores the association between medical professionalism, revenue
      enhancement, and self-interest. Utilizing the sociological literature, I begin by
      characterizing professionalism generally and medical professionalism
      particularly. I then consider "pay for performance" mechanisms as an example of
      one way physicians might be incentivized to improve their professionalism and, at
      the same time, enhance their revenue. I suggest that the concern discussed in
      much of the medical professionalism literature that physicians might act on the
      basis of self-interest is over-generalized, and that instead we ought to argue
      about ways to distinguish permissible and impermissible self-interested actions. 
      Also, I argue that financial incentives for medical professionals ought to be
      permissible but considered as "by-products" of doing what physicians are expected
      to do as professionals in any case. Nevertheless, I conclude that, even if a
      positive association between increasing professionalism and revenue enhancement
      can be established, in the long term it may not be an unambiguous good for
      physicians as professionals in that this association may tend to reduce their
      professional discretion.
FAU - Heller, Jan C
AU  - Heller JC
AD  - Ethics and Spiritual Care, PeaceHealth Southwest Medical Center, 400 NE Mother
      Joseph Place, PO Box 1600, Vancouver, WA 98668, USA. jan.c.heller@gmail.com
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - Delivery of Health Care/*economics
MH  - Humans
MH  - Medical Staff, Hospital/*psychology
MH  - *Professional Competence
MH  - Reimbursement, Incentive/*ethics
MH  - United States
EDAT- 2012/10/30 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/10/30 06:00
PHST- 2012/10/30 06:00 [entrez]
PHST- 2012/10/30 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1007/s10730-012-9198-5 [doi]
PST - ppublish
SO  - HEC Forum. 2012 Dec;24(4):307-15. doi: 10.1007/s10730-012-9198-5.


PMID- 23104511
OWN - NLM
STAT- MEDLINE
DCOM- 20130530
LR  - 20220410
IS  - 1477-030X (Electronic)
IS  - 0269-2163 (Linking)
VI  - 27
IP  - 1
DP  - 2013 Jan
TI  - Perspectives of decision-making in requests for euthanasia: a qualitative
      research among patients, relatives and treating physicians in the Netherlands.
PG  - 27-37
LID - 10.1177/0269216312463259 [doi]
AB  - BACKGROUND: Euthanasia has been legally performed in the Netherlands since 2002. 
      Respect for patient's autonomy is the underpinning ethical principal. However,
      patients have no right to euthanasia, and physicians have no obligation to
      provide it. Although over 3000 cases are conducted per year in the Netherlands,
      there is little known about how decision-making occurs and no guidance to support
      this difficult aspect of clinical practice. AIM: To explore the decision-making
      process in cases where patients request euthanasia and understand the different
      themes relevant to optimise this decision-making process. DESIGN: A qualitative
      thematic analysis of interviews with patients making explicit requests for
      euthanasia, most-involved relative(s) and treating physician.
      PARTICIPANTS/SETTING: Thirty-two cases, 31 relatives and 28 treating physicians. 
      Settings were patients' and relatives' homes and physicians' offices. RESULTS:
      Five main themes emerged: (1) initiation of sharing views and values about
      euthanasia, (2) building relationships as part of the negotiation, (3) fulfilling
      legal requirements, (4) detailed work of preparing and performing euthanasia and 
      (5) aftercare and closing. CONCLUSIONS: A patient's request for euthanasia
      entails a complex process that demands emotional work by all participants. It is 
      characterised by an intensive period of sharing information, relationship
      building and negotiation in order to reach agreement. We hypothesise that making 
      decisions about euthanasia demands a proactive approach towards participants'
      preferences and values regarding end of life, towards the needs of relatives,
      towards the burden placed on physicians and a careful attention to shared
      decision-making. Future research should address the communicational skills
      professionals require for such complex decision-making.
FAU - Dees, Marianne K
AU  - Dees MK
AD  - Department of Primary and Community Care, Radboud University Nijmegen Medical
      Centre, Nijmegen, the Netherlands. m.dees@elg.umcn.nl
FAU - Vernooij-Dassen, Myrra J
AU  - Vernooij-Dassen MJ
FAU - Dekkers, Wim J
AU  - Dekkers WJ
FAU - Elwyn, Glyn
AU  - Elwyn G
FAU - Vissers, Kris C
AU  - Vissers KC
FAU - van Weel, Chris
AU  - van Weel C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121026
PL  - England
TA  - Palliat Med
JT  - Palliative medicine
JID - 8704926
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Attitude of Health Personnel
MH  - Communication
MH  - *Decision Making
MH  - *Euthanasia, Active, Voluntary/legislation & jurisprudence/psychology
MH  - Family/*psychology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Negotiating
MH  - Netherlands
MH  - Physician-Patient Relations
MH  - Qualitative Research
MH  - Surveys and Questionnaires
EDAT- 2012/10/30 06:00
MHDA- 2013/06/01 06:00
CRDT- 2012/10/30 06:00
PHST- 2012/10/30 06:00 [entrez]
PHST- 2012/10/30 06:00 [pubmed]
PHST- 2013/06/01 06:00 [medline]
AID - 0269216312463259 [pii]
AID - 10.1177/0269216312463259 [doi]
PST - ppublish
SO  - Palliat Med. 2013 Jan;27(1):27-37. doi: 10.1177/0269216312463259. Epub 2012 Oct
      26.


PMID- 23104048
OWN - NLM
STAT- MEDLINE
DCOM- 20130523
LR  - 20211021
IS  - 1527-974X (Electronic)
IS  - 1067-5027 (Linking)
VI  - 20
IP  - 1
DP  - 2013 Jan 1
TI  - Sorrell v. IMS Health: issues and opportunities for informaticians.
PG  - 35-7
LID - 10.1136/amiajnl-2012-001123 [doi]
AB  - In 2011, the US Supreme Court decided Sorrell v. IMS Health, Inc., a case that
      addressed the mining of large aggregated databases and the sale of prescriber
      data for marketing prescription drugs. The court struck down a Vermont law that
      required data mining companies to obtain permission from individual providers
      before selling prescription records that included identifiable physician
      prescription information to pharmaceutical companies for drug marketing. The
      decision was based on constitutional free speech protections rather than data
      sharing considerations. Sorrell illustrates challenges at the intersection of
      biomedical informatics, public health, constitutional liberties, and ethics. As
      states, courts, regulatory agencies, and federal bodies respond to Sorrell,
      informaticians' expertise can contribute to more informed, ethical, and
      appropriate policies.
FAU - Petersen, Carolyn
AU  - Petersen C
AD  - Global Business Solutions, Mayo Clinic, Rochester, MN 55905, USA.
      petersen.carolyn@mayo.edu
FAU - Demuro, Paul
AU  - Demuro P
FAU - Goodman, Kenneth W
AU  - Goodman KW
FAU - Kaplan, Bonnie
AU  - Kaplan B
LA  - eng
PT  - Journal Article
PT  - Legal Case
DEP - 20121027
PL  - England
TA  - J Am Med Inform Assoc
JT  - Journal of the American Medical Informatics Association : JAMIA
JID - 9430800
SB  - IM
MH  - Confidentiality/*legislation & jurisprudence
MH  - Data Mining/legislation & jurisprudence
MH  - Drug Industry/legislation & jurisprudence
MH  - *Drug Prescriptions
MH  - Electronic Health Records/*legislation & jurisprudence
MH  - Health Insurance Portability and Accountability Act/legislation & jurisprudence
MH  - Humans
MH  - Information Dissemination/*legislation & jurisprudence
MH  - Marketing/*legislation & jurisprudence
MH  - Pharmacy Service, Hospital/legislation & jurisprudence
MH  - Supreme Court Decisions
MH  - United States
MH  - Vermont
PMC - PMC3555336
EDAT- 2012/10/30 06:00
MHDA- 2013/05/25 06:00
CRDT- 2012/10/30 06:00
PHST- 2012/10/30 06:00 [entrez]
PHST- 2012/10/30 06:00 [pubmed]
PHST- 2013/05/25 06:00 [medline]
AID - amiajnl-2012-001123 [pii]
AID - 10.1136/amiajnl-2012-001123 [doi]
PST - ppublish
SO  - J Am Med Inform Assoc. 2013 Jan 1;20(1):35-7. doi: 10.1136/amiajnl-2012-001123.
      Epub 2012 Oct 27.


PMID- 23103609
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121030
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 5
DP  - 2012
TI  - Applying the RE-AIM framework to the Alberta's Caring for Diabetes Project: a
      protocol for a comprehensive evaluation of primary care quality improvement
      interventions.
LID - 10.1136/bmjopen-2012-002099 [doi]
LID - e002099 [pii]
AB  - INTRODUCTION: Diabetes represents a major public health and health system burden.
      As part of the Alberta's Caring for Diabetes (ABCD) Project, two
      quality-improvement interventions are being piloted in four Primary Care Networks
      in Alberta. Gaps between health research, policy and practice have been
      documented and the need to evaluate the impact of public health interventions in 
      real-world settings to inform decision-making and clinical practice is paramount.
      In this article, we describe the application of the RE-AIM framework to evaluate 
      the interventions beyond effectiveness. METHODS AND ANALYSIS: Two
      quality-improvement interventions were implemented, based on previously proven
      effective models of care and are directed at improving the physical and mental
      health of patients with type-2 diabetes. Our goal is to adapt and apply the
      RE-AIM framework, using a mixed-methods approach, to understand the impact of the
      interventions to inform policy and clinical decision-making. We present the
      proposed measures, data sources and data management and analysis strategies used 
      to evaluate the interventions by RE-AIM dimension. ETHICS AND DISSEMINATION:
      Ethics approval for the ABCD Project has been granted from the Health Research
      Ethics Board (HREB #PRO00012663) at the University of Alberta. The RE-AIM
      framework will be used to structure our dissemination activities by dimension.
      RESULTS: It will be presented at relevant conferences and prepared for
      publication in peer-reviewed journals. Various products, such as presentations,
      briefing reports and webinars, will be developed to inform key stakeholders of
      the findings. Presentation of findings by RE-AIM dimension will facilitate
      discussion regarding the public health impact of the two interventions within the
      primary care context of Alberta and lessons learned to be used in programme
      planning and care delivery for patients with type-2 diabetes. It will also
      promote the application of evaluation models to better assess the impact of
      community-based primary healthcare interventions through our dissemination
      activities.
FAU - Wozniak, Lisa
AU  - Wozniak L
AD  - ACHORD, University of Alberta, Edmonton, Alberta, Canada.
FAU - Rees, Sandra
AU  - Rees S
FAU - Soprovich, Allison
AU  - Soprovich A
FAU - Al Sayah, Fatima
AU  - Al Sayah F
FAU - Johnson, Steven T
AU  - Johnson ST
FAU - Majumdar, Sumit R
AU  - Majumdar SR
FAU - Johnson, Jeffrey A
AU  - Johnson JA
LA  - eng
PT  - Journal Article
DEP - 20121026
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3488740
EDAT- 2012/10/30 06:00
MHDA- 2012/10/30 06:01
CRDT- 2012/10/30 06:00
PHST- 2012/10/30 06:00 [entrez]
PHST- 2012/10/30 06:00 [pubmed]
PHST- 2012/10/30 06:01 [medline]
AID - bmjopen-2012-002099 [pii]
AID - 10.1136/bmjopen-2012-002099 [doi]
PST - epublish
SO  - BMJ Open. 2012 Oct 26;2(5). pii: bmjopen-2012-002099. doi:
      10.1136/bmjopen-2012-002099. Print 2012.


PMID- 23103349
OWN - NLM
STAT- MEDLINE
DCOM- 20130510
LR  - 20220410
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 75
IP  - 12
DP  - 2012 Dec
TI  - Affordability as a discursive accomplishment in a changing National Health
      Service.
PG  - 2463-71
LID - 10.1016/j.socscimed.2012.09.026 [doi]
LID - S0277-9536(12)00690-9 [pii]
AB  - Health systems worldwide face the challenges of rationing. The English National
      Health Service (NHS) was founded on three core principles: universality,
      comprehensiveness, and free at the point of delivery. Yet patients are
      increasingly hearing that some treatments are unaffordable on the NHS. We
      considered affordability as a social accomplishment and sought to explore how
      those charged with allocating NHS resources achieved this in practice. We
      undertook a linguistic ethnography to examine the work practices of resource
      allocation committees in three Primary Care Trusts (PCTs) in England between 2005
      and 2012, specifically deliberations over 'individual funding requests'
      (IFRs)--requests by patients and their doctors for the PCT to support a treatment
      not routinely funded. We collected and analysed a diverse dataset comprising
      policy documents, legal judgements, audio recordings, ethnographic field notes
      and emails from PCT committee meetings, interviews and a focus group with
      committee members. We found that the fundamental values of universality and
      comprehensiveness strongly influenced the culture of these NHS organisations, and
      that in this context, accomplishing affordability was not easy. Four discursive
      practices served to confer legitimacy on affordability as a guiding value of NHS 
      health care: (1) categorising certain treatments as only eligible for NHS funding
      if patients could prove 'exceptional' circumstances; (2) representing resource
      allocation decisions as being not (primarily) about money; (3) indexical
      labelling of affordability as an ethical principle, and (4) recontextualising
      legal judgements supporting refusal of NHS treatment on affordability grounds as 
      'rational'. The overall effect of these discursive practices was that denying
      treatment to patients became reasonable and rational for an organisation even
      while it continued to espouse traditional NHS values. We conclude that
      deliberations about the funding of treatments at the margins of NHS care have
      powerful consequences both for patients and for redrawing the ideological
      landscape of NHS care.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Russell, Jill
AU  - Russell J
AD  - Barts and The London School of Medicine and Dentistry, Queen Mary University of
      London, Yvonne Carter Building, 58 Turner Street, London E1 2AB, UK.
      j.russell@qmul.ac.uk
FAU - Greenhalgh, Trisha
AU  - Greenhalgh T
LA  - eng
GR  - HS&DR/10/1011/01/DH_/Department of Health/United Kingdom
GR  - PB-PG-1207-15061/DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120928
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Delivery of Health Care/*economics
MH  - Eligibility Determination
MH  - England
MH  - *Financing, Government
MH  - Hospitals, Public
MH  - Humans
MH  - Qualitative Research
MH  - Refusal to Treat/ethics/legislation & jurisprudence
MH  - Resource Allocation/*economics
MH  - State Medicine
EDAT- 2012/10/30 06:00
MHDA- 2013/05/11 06:00
CRDT- 2012/10/30 06:00
PHST- 2012/03/27 00:00 [received]
PHST- 2012/09/17 00:00 [revised]
PHST- 2012/09/19 00:00 [accepted]
PHST- 2012/10/30 06:00 [entrez]
PHST- 2012/10/30 06:00 [pubmed]
PHST- 2013/05/11 06:00 [medline]
AID - S0277-9536(12)00690-9 [pii]
AID - 10.1016/j.socscimed.2012.09.026 [doi]
PST - ppublish
SO  - Soc Sci Med. 2012 Dec;75(12):2463-71. doi: 10.1016/j.socscimed.2012.09.026. Epub 
      2012 Sep 28.


PMID- 23102754
OWN - NLM
STAT- MEDLINE
DCOM- 20140129
LR  - 20151119
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 96
DP  - 2013 Nov
TI  - Medical professionalism among clinical physicians in two tertiary hospitals,
      China.
PG  - 290-6
LID - 10.1016/j.socscimed.2012.09.044 [doi]
LID - S0277-9536(12)00710-1 [pii]
AB  - In order to investigate medical professional attitudes and behaviors in China and
      explore the influencing factors with a focus on hospital internal management, we 
      developed a 13-item professional attitudes and 11-item behaviors inventory.
      Self-administered questionnaires were distributed to 390 physicians mainly in
      four specialties in two tertiary Chinese hospitals in 2011. 306 completed
      questionnaires were collected. More than 90% of respondents agreed with at least 
      nine of the 13 specific statements about principles. However, responses on
      behaviors were not necessarily consistent with those on attitudes. 80.3% of
      respondents reported that they usually or always participated in quality
      improvement activities and 48.2% reported that they usually or always
      participated in peer evaluations of colleagues' quality of care. Some 47.8% had
      encountered incompetent colleagues and 17.7% had encountered significant medical 
      errors caused by colleagues. Among those who had encountered incompetence or
      significant medical errors, almost two thirds had never reported their concerns
      to the hospital or other relevant authorities. Half of the physicians did not
      obtain enough continuing medical education credits. Physicians' professional
      reported behaviors were influenced by their personal and professional
      characteristics, professional attitudes, and assessment of hospital internal
      management constitutions. For example, participation in decision-making had a
      significant role in professional reported behaviors of protecting patient
      confidentiality, improving quality of care, and self-regulation, with those
      sometimes or often participating in decision-making indicating higher levels of
      reported behaviors than those who seldom participated (odds ratios: 1.84; 4.31,
      2.44; 3.31). The results showed Chinese physicians demonstrated positive
      attitudes to professionalism principles. However, their reported behaviors were
      at times inconsistent with their attitudes, especially in the areas of
      competence, quality improvement, and self-regulation. One of effective strategies
      to facilitate Chinese physicians' professionalism may be to improving hospital
      management.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Chen, Jing
AU  - Chen J
AD  - School of Medical and Health Management, Tongji Medical College, Huazhong
      University of Science & Technology, Wuhan, China. Electronic address:
      chenjing@mails.tjmu.edu.cn.
FAU - Xu, Juan
AU  - Xu J
FAU - Zhang, Chunmei
AU  - Zhang C
FAU - Fu, Xinqiao
AU  - Fu X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121017
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - China
MH  - Clinical Competence
MH  - Female
MH  - Humans
MH  - Male
MH  - Physicians/*psychology/statistics & numerical data
MH  - Pilot Projects
MH  - Professional Autonomy
MH  - Quality Improvement
MH  - Surveys and Questionnaires
MH  - Tertiary Care Centers/*organization & administration
OTO - NOTNLM
OT  - Attitude of health personnel
OT  - China
OT  - Hospital management
OT  - Medical ethics
OT  - Medical professionalism
EDAT- 2012/10/30 06:00
MHDA- 2014/01/30 06:00
CRDT- 2012/10/30 06:00
PHST- 2012/03/12 00:00 [received]
PHST- 2012/07/26 00:00 [revised]
PHST- 2012/09/27 00:00 [accepted]
PHST- 2012/10/30 06:00 [entrez]
PHST- 2012/10/30 06:00 [pubmed]
PHST- 2014/01/30 06:00 [medline]
AID - S0277-9536(12)00710-1 [pii]
AID - 10.1016/j.socscimed.2012.09.044 [doi]
PST - ppublish
SO  - Soc Sci Med. 2013 Nov;96:290-6. doi: 10.1016/j.socscimed.2012.09.044. Epub 2012
      Oct 17.


PMID- 23102752
OWN - NLM
STAT- MEDLINE
DCOM- 20131203
LR  - 20130715
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 91
DP  - 2013 Aug
TI  - The emotional overlay: older person and carer perspectives on negotiating aging
      and care in rural Ontario.
PG  - 186-93
LID - 10.1016/j.socscimed.2012.08.037 [doi]
LID - S0277-9536(12)00703-4 [pii]
AB  - This paper extends the burgeoning interest in emotion, health and place by
      investigating the emotionally complex experiences of aging and care in rural
      settings. Featuring a thematic analysis of 44 semi-structured interviews and two 
      focus groups with older people and their carers in rural Ontario (Canada) we
      examine the importance and implications of emotions within and across multiple
      scales at which care relationships, expectations and responsibilities are
      negotiated. With the aim of broadening the discussion surrounding geographical
      dimensions of ethical care, our approach draws on feminist care ethics to
      understand the multifaceted ways in which emotions shape and are shaped by
      experiences of aging and caring at the interpersonal, household and community
      scales. The findings reveal how emotions are central, yet often-overlooked and
      even hidden within care relationships among older rural people and their carers. 
      We argue that ethical care is contingent on recognizing and valuing the situated 
      emotions involved in doing care work, sustaining care relationships and asking
      for care. In doing so, we demonstrate how qualitative research on the emotional
      geographies of care can contribute to the development of informed policies that
      are contextually sensitive and, ultimately, have the potential to build more
      ethical rural conditions of care.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Herron, Rachel V
AU  - Herron RV
AD  - Department of Geography, Queen's University, Mackintosh-Corry Hall, Kingston,
      Ontario, Canada K7L 3N6. 4rh11@queensu.ca
FAU - Skinner, Mark W
AU  - Skinner MW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121016
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*psychology
MH  - *Attitude to Health
MH  - Caregivers/*psychology
MH  - *Emotions
MH  - Female
MH  - Focus Groups
MH  - Health Services for the Aged/*ethics
MH  - Humans
MH  - Male
MH  - *Negotiating
MH  - Ontario
MH  - Qualitative Research
MH  - Rural Health Services/*ethics
OTO - NOTNLM
OT  - Canada
OT  - Care ethics
OT  - Emotional geographies
OT  - Rural aging
OT  - Scales of care
EDAT- 2012/10/30 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/10/30 06:00
PHST- 2012/01/16 00:00 [received]
PHST- 2012/06/25 00:00 [revised]
PHST- 2012/08/16 00:00 [accepted]
PHST- 2012/10/30 06:00 [entrez]
PHST- 2012/10/30 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - S0277-9536(12)00703-4 [pii]
AID - 10.1016/j.socscimed.2012.08.037 [doi]
PST - ppublish
SO  - Soc Sci Med. 2013 Aug;91:186-93. doi: 10.1016/j.socscimed.2012.08.037. Epub 2012 
      Oct 16.


PMID- 23102720
OWN - NLM
STAT- MEDLINE
DCOM- 20130522
LR  - 20191210
IS  - 1873-7757 (Electronic)
IS  - 0145-2134 (Linking)
VI  - 36
IP  - 10
DP  - 2012 Oct
TI  - Systems, strategies, and interventions for sustainable long-term care and
      protection of children with a history of living outside of family care.
PG  - 722-31
LID - 10.1016/j.chiabu.2012.09.005 [doi]
LID - S0145-2134(12)00186-X [pii]
AB  - OBJECTIVES: This article reviews the available evidence regarding the efficacy,
      effectiveness, ethics, and sustainability of approaches to strengthen systems to 
      care for and protect children living outside family care in low- and
      middle-income countries. METHOD: For trafficked children, children of and on the 
      street, children of conflict/disaster, and institutionalized children, a systems 
      framework approach was used to organize the topic of sustainable approaches in
      low- and middle-income countries and addresses the following: legislation,
      policies, and regulations; system structures and functions (formal and informal);
      and continuum of care and services. The article draws on the findings of a focal 
      group convened by the U.S. Government Evidence Summit: Protecting Children
      Outside of Family Care (December 12-13, 2011, Washington, DC), tasked with
      reviewing the literature on systems, strategies, and interventions for
      sustainable long-term care and protection of children with a history of living
      outside of family care in low- and middle-income country contexts. The specific
      methodology for the review is described in the commentary paper (Higgs, Zlidar, &
      Balster, 2012) that accompanies these papers. RESULTS: For the most part, the
      evidence base in support of sustainable long-term care for the populations of
      interest is relatively weak, with some stronger but unreplicated studies. Some
      populations have been studied more thoroughly than others, and there are many
      gaps. Most of the existing studies identify population characteristics, needs,
      and consequences of a lack of systemic services to promote family-like care.
      There is some evidence of the effectiveness of laws and policies, as well as some
      evidence of service effectiveness, in improving outcomes for children outside of 
      family care. CONCLUSIONS: Despite the weaknesses and gaps of the existing
      research, there is a foundation of research for going forward, which should focus
      on developing and implementing systems for these most vulnerable children. The
      evidence reviewed indicates that child protection systems should aim for
      appropriate, permanent family care (including reunification, adoption, kinship
      care, or kafalah) for children in order to secure the best environment for a
      child's developmental prospects. Evidence also suggests that the quality and
      duration of care, including both permanent family care and alternative care, are 
      important regardless of setting. The diversity of political, socioeconomic,
      historical, regional, community, and cultural contexts in which child protection 
      systems operate need to be taken into account during programming and research
      design.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Fluke, John D
AU  - Fluke JD
AD  - Kempe Center for the Prevention and Treatment of Child Abuse and Neglect,
      Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO
      80045, USA.
FAU - Goldman, Philip S
AU  - Goldman PS
FAU - Shriberg, Janet
AU  - Shriberg J
FAU - Hillis, Susan D
AU  - Hillis SD
FAU - Yun, Katherine
AU  - Yun K
FAU - Allison, Susannah
AU  - Allison S
FAU - Light, Enid
AU  - Light E
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121024
PL  - England
TA  - Child Abuse Negl
JT  - Child abuse & neglect
JID - 7801702
SB  - IM
MH  - Child
MH  - Child Abuse/*rehabilitation
MH  - Child Abuse, Sexual
MH  - Child Welfare/*ethics/*legislation & jurisprudence
MH  - Child, Institutionalized
MH  - Conflict, Psychological
MH  - Crime Victims
MH  - Disasters
MH  - Family
MH  - Homeless Youth
MH  - Humans
MH  - Long-Term Care/ethics/legislation & jurisprudence/methods
MH  - Poverty
EDAT- 2012/10/30 06:00
MHDA- 2013/05/23 06:00
CRDT- 2012/10/30 06:00
PHST- 2012/09/07 00:00 [received]
PHST- 2012/09/07 00:00 [accepted]
PHST- 2012/10/30 06:00 [entrez]
PHST- 2012/10/30 06:00 [pubmed]
PHST- 2013/05/23 06:00 [medline]
AID - S0145-2134(12)00186-X [pii]
AID - 10.1016/j.chiabu.2012.09.005 [doi]
PST - ppublish
SO  - Child Abuse Negl. 2012 Oct;36(10):722-31. doi: 10.1016/j.chiabu.2012.09.005. Epub
      2012 Oct 24.


PMID- 23102682
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20211021
IS  - 1097-685X (Electronic)
IS  - 0022-5223 (Linking)
VI  - 145
IP  - 1
DP  - 2013 Jan
TI  - Are surgeons ethically obligated to treat Medicare patients despite substantial
      reductions in reimbursement? Introduction.
PG  - 37
LID - 10.1016/j.jtcvs.2012.09.067 [doi]
LID - S0022-5223(12)01224-X [pii]
FAU - Sade, Robert M
AU  - Sade RM
LA  - eng
GR  - UL1 RR029882/RR/NCRR NIH HHS/United States
GR  - UL1RR029882/RR/NCRR NIH HHS/United States
PT  - Editorial
PT  - Introductory Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20121023
PL  - United States
TA  - J Thorac Cardiovasc Surg
JT  - The Journal of thoracic and cardiovascular surgery
JID - 0376343
SB  - IM
MH  - Attitude of Health Personnel
MH  - Cardiac Surgical Procedures/economics/*ethics/legislation & jurisprudence
MH  - Conflict of Interest
MH  - Government Regulation
MH  - Health Policy/economics
MH  - Hippocratic Oath
MH  - Humans
MH  - Income
MH  - Insurance, Health, Reimbursement/economics/*ethics/legislation & jurisprudence
MH  - Medicare/economics/*ethics/legislation & jurisprudence
MH  - *Moral Obligations
MH  - Physicians/economics/*ethics/legislation & jurisprudence
MH  - United States
PMC - PMC4477685
MID - NIHMS698536
EDAT- 2012/10/30 06:00
MHDA- 2013/03/13 06:00
CRDT- 2012/10/30 06:00
PHST- 2012/09/13 00:00 [received]
PHST- 2012/09/24 00:00 [accepted]
PHST- 2012/10/30 06:00 [entrez]
PHST- 2012/10/30 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
AID - S0022-5223(12)01224-X [pii]
AID - 10.1016/j.jtcvs.2012.09.067 [doi]
PST - ppublish
SO  - J Thorac Cardiovasc Surg. 2013 Jan;145(1):37. doi: 10.1016/j.jtcvs.2012.09.067.
      Epub 2012 Oct 23.


PMID- 23102161
OWN - NLM
STAT- MEDLINE
DCOM- 20130919
LR  - 20130308
IS  - 1466-187X (Electronic)
IS  - 0142-159X (Linking)
VI  - 35
IP  - 3
DP  - 2013
TI  - The obligation of debriefing in global health education.
PG  - e1027-34
LID - 10.3109/0142159X.2012.733449 [doi]
AB  - BACKGROUND: An outcome of globalization and internationalization in higher
      education in the health professions has been increasing global health placements.
      There is, however, a lack of literature on debriefing and support following these
      placements. The authors undertook a participatory project to develop peer support
      and debriefing in a global health nursing elective, during which this gap in
      literature was addressed. AIMS: The purpose of the project was to develop a peer 
      support component of the course and revise the debriefing component based on
      results of a previous course evaluation. METHODS: The methods were guided by a
      participatory approach involving course alumni and included a scoping review and 
      focus groups. RESULTS: The project resulted in development of: (1) a peer support
      statement and (2) a debriefing framework. CONCLUSIONS: Key lessons about the
      obligation of appropriate debriefing for students returning from global health
      placements include importance of affective learning, a pedagogy of discomfort,
      and global health ethics.
FAU - Bender, Amy
AU  - Bender A
AD  - Lawrence S. Bloomberg Faculty of Nursing, University of Toronto, Canada.
      amy.bender@utoronto.ca
FAU - Walker, Pamela
AU  - Walker P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121026
PL  - England
TA  - Med Teach
JT  - Medical teacher
JID - 7909593
SB  - IM
MH  - *Focus Groups
MH  - Group Processes
MH  - *Health Education
MH  - Health Occupations
MH  - Humans
MH  - *Internationality
MH  - Interview, Psychological/methods
MH  - *Learning
MH  - Peer Group
EDAT- 2012/10/30 06:00
MHDA- 2013/09/21 06:00
CRDT- 2012/10/30 06:00
PHST- 2012/10/30 06:00 [entrez]
PHST- 2012/10/30 06:00 [pubmed]
PHST- 2013/09/21 06:00 [medline]
AID - 10.3109/0142159X.2012.733449 [doi]
PST - ppublish
SO  - Med Teach. 2013;35(3):e1027-34. doi: 10.3109/0142159X.2012.733449. Epub 2012 Oct 
      26.


PMID- 23102158
OWN - NLM
STAT- MEDLINE
DCOM- 20130919
LR  - 20220331
IS  - 1466-187X (Electronic)
IS  - 0142-159X (Linking)
VI  - 35
IP  - 3
DP  - 2013
TI  - How we teach ethics and communication during a Canadian neonatal perinatal
      medicine residency: an interactive experience.
PG  - 194-200
LID - 10.3109/0142159X.2012.733452 [doi]
AB  - BACKGROUND: Ethically challenging clinical situations frequently confront health 
      care professionals in neonatology. These situations require neonatologists to
      exercise professionalism by communicating effectively throughout evolving
      physician-parent relationships in order to arrive at shared decisions for care
      that are in the best interest of the neonate and grounded solidly in ethical
      precepts. AIM: This article describes the process by which a well-delineated,
      interactive program to teach ethical reasoning and skillful communication with
      parents was implemented at the University of Ottawa, Canada. METHODS: A revised
      ethics program implemented in 2009 identified competencies that should be
      demonstrated at the end of the Neonatal-Perinatal Medicine (NPM) residency.
      Several seminars were refined while new workshops, problem-based learning in
      ethics, and a personal portfolio were added. RESULTS: All teaching strategies
      were well received based on the average level of satisfaction (5.8 out of 7, SD
      0.4). We are now moving forward by formally assessing our program including the
      impact on knowledge acquisition and behavior. CONCLUSION: A dedicated,
      interactive competency-based neonatal ethics teaching program is vital to support
      NPM trainees in learning how to integrate ethical thinking with competencies in
      communication.
FAU - Daboval, Thierry
AU  - Daboval T
AD  - Department of Pediatrics, Division of Neonatology, Faculty of Medicine, Children 
      Hospital of Eastern Ontario (CHEO), The University of Ottawa, Canada.
      tdaboval@cheo.on.ca
FAU - Moore, Gregory P
AU  - Moore GP
FAU - Ferretti, Emanuela
AU  - Ferretti E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121026
PL  - England
TA  - Med Teach
JT  - Medical teacher
JID - 7909593
SB  - IM
MH  - *Communication
MH  - Ethics, Medical/*education
MH  - Internship and Residency
MH  - Neonatology/*education/ethics
MH  - Ontario
MH  - Program Development
MH  - Teaching/*methods
EDAT- 2012/10/30 06:00
MHDA- 2013/09/21 06:00
CRDT- 2012/10/30 06:00
PHST- 2012/10/30 06:00 [entrez]
PHST- 2012/10/30 06:00 [pubmed]
PHST- 2013/09/21 06:00 [medline]
AID - 10.3109/0142159X.2012.733452 [doi]
PST - ppublish
SO  - Med Teach. 2013;35(3):194-200. doi: 10.3109/0142159X.2012.733452. Epub 2012 Oct
      26.


PMID- 23101963
OWN - NLM
STAT- MEDLINE
DCOM- 20130415
LR  - 20121029
IS  - 1166-7087 (Print)
IS  - 1166-7087 (Linking)
VI  - 22
IP  - 14
DP  - 2012 Nov
TI  - [Urology and ambulatory surgery].
PG  - 898-902
LID - 10.1016/j.purol.2012.07.009 [doi]
LID - S1166-7087(12)00203-5 [pii]
AB  - The ambulatory surgery is the realization of a surgical act with entrance and
      taken out the same day. The evolution of the surgery in traditional
      hospitalization towards the ambulatory is a cultural revolution. The function
      care and accommodation of our establishments of health are disconnected. The
      ambulatory surgery is source of progress for the surgery, the anesthesia, our
      organizations. She corresponds to a demand of the public. She is ethical. There
      is an institutional will shared by all the actors of health today. The AFU
      measured its delay and has the objective to facilitate to the urologic community 
      this mode of taken care. Learned recommendations are going to be produced in
      association with the HAS. The role of the IDE of urology is specified there.
CI  - Copyright (c) 2012 Elsevier Masson SAS. All rights reserved.
FAU - Cuvelier, G
AU  - Cuvelier G
AD  - Centre hospitalier de Cornouaille, 14, avenue Yves-Thepot, BP 1757, 29107
      Quimper, France. g.cuvelier@ch-cornouaille.fr
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Chirurgie urologique et ambulatoire.
DEP - 20120905
PL  - France
TA  - Prog Urol
JT  - Progres en urologie : journal de l'Association francaise d'urologie et de la
      Societe francaise d'urologie
JID - 9307844
SB  - IM
MH  - *Ambulatory Surgical Procedures
MH  - Humans
MH  - Urologic Surgical Procedures/*methods
EDAT- 2012/10/30 06:00
MHDA- 2013/04/16 06:00
CRDT- 2012/10/30 06:00
PHST- 2012/07/11 00:00 [received]
PHST- 2012/07/13 00:00 [accepted]
PHST- 2012/10/30 06:00 [entrez]
PHST- 2012/10/30 06:00 [pubmed]
PHST- 2013/04/16 06:00 [medline]
AID - S1166-7087(12)00203-5 [pii]
AID - 10.1016/j.purol.2012.07.009 [doi]
PST - ppublish
SO  - Prog Urol. 2012 Nov;22(14):898-902. doi: 10.1016/j.purol.2012.07.009. Epub 2012
      Sep 5.


PMID- 23101414
OWN - NLM
STAT- MEDLINE
DCOM- 20121204
LR  - 20121029
IS  - 1565-1088 (Print)
VI  - 14
IP  - 9
DP  - 2012 Sep
TI  - Quo vadis, bioethics.
PG  - 535-7
AB  - The recent paper by Giubilini and Minerva suggesting the ethical permissibility
      of infanticide of normal newborns, calling it "postbirth abortion," represents a 
      dangerous deterioration of generally accepted ethical norms. Their proposal
      represents a clear example of the so-called slippery slope and we caution against
      abandoning the age-old traditions of the medical profession assigning intrinsic
      value to human life from birth. This article discusses the proposed concept,
      makes comparisons with earlier similar trends of thought, and highlights the
      dangers of the proposal.
FAU - Glick, Shimon M
AU  - Glick SM
AD  - Jakobovits Center for Jewish Medical Ethics, Faculty of Health Sciences,
      Ben-Gurion University of the Negev, Beer Sheva, Israel. gshimon@bgu.ac.il
FAU - Jotkowitz, Alan B
AU  - Jotkowitz AB
LA  - eng
PT  - Journal Article
PL  - Israel
TA  - Isr Med Assoc J
JT  - The Israel Medical Association journal : IMAJ
JID - 100930740
SB  - IM
MH  - Abortion, Induced/*ethics
MH  - Dissent and Disputes
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Infanticide/*ethics
MH  - Morals
MH  - Personhood
MH  - Pregnancy
MH  - *Value of Life
EDAT- 2012/10/30 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/10/30 06:00
PHST- 2012/10/30 06:00 [entrez]
PHST- 2012/10/30 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
PST - ppublish
SO  - Isr Med Assoc J. 2012 Sep;14(9):535-7.


PMID- 23101349
OWN - NLM
STAT- MEDLINE
DCOM- 20121207
LR  - 20191112
IS  - 1322-7696 (Print)
IS  - 1322-7696 (Linking)
VI  - 19
IP  - 3
DP  - 2012
TI  - Interdisciplinary collisions: bringing healthcare professionals together.
PG  - 145-51
AB  - Since the publication of its reports, Health professions education: A bridge to
      quality (2003) and To err is human: Building a safer health system (2000), the
      Institute of Medicine has continued to emphasize interprofessional education
      (IPE), founded on quality improvement and informatics, as a better way to prepare
      healthcare professionals for practice. As this trend continues, healthcare
      education will need to implement administrative and educational processes that
      encourage different professions to collaborate and share resources. With greater 
      numbers of students enrolled in health professional programs, combined with
      ethical imperatives for learning and reduced access to quality clinical
      experiences, medical and nursing education increasingly rely on simulation
      education to implement interdisciplinary patient safety initiatives. In this
      article, the authors describe one approach, based on the Core Competencies for
      Interprofessional Collaborative Practice released by the Interprofessional
      Education Collaborative (2011), toward providing IPE to an audience of diverse
      healthcare professionals in academia and clinical practice. This approach
      combines professional standards with the authors' practical experience serving on
      a key operations committee, comprising members from a school of medicine, a
      school of nursing, and a large healthcare system, to design and implement a new
      state-of-the-art simulation center and its IPE-centered curriculum.
FAU - Engum, Scott A
AU  - Engum SA
AD  - Division of Pediatric Surgery, James Whitcomb Riley Hospital for Children, 702
      Barnhill Drive, Suite 2500, Indianapolis, IN 46201, USA. sengum@iupui.edu
FAU - Jeffries, Pamela R
AU  - Jeffries PR
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Collegian
JT  - Collegian (Royal College of Nursing, Australia)
JID - 9612493
MH  - Communication
MH  - Competency-Based Education/*methods
MH  - Decision Making
MH  - *Education, Professional
MH  - Group Processes
MH  - Humans
MH  - *Interdisciplinary Studies
MH  - *Manikins
MH  - Patient Care Team
MH  - United States
EDAT- 2012/10/30 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/10/30 06:00
PHST- 2012/10/30 06:00 [entrez]
PHST- 2012/10/30 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - 10.1016/j.colegn.2012.05.005 [doi]
PST - ppublish
SO  - Collegian. 2012;19(3):145-51. doi: 10.1016/j.colegn.2012.05.005.


PMID- 23101265
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20121029
IS  - 0023-2149 (Print)
IS  - 0023-2149 (Linking)
VI  - 90
IP  - 8
DP  - 2012
TI  - [Bioethics or medical (deontological) ethics? Main principles of medical ethics].
PG  - 69-72
FAU - Saperov, V N
AU  - Saperov VN
LA  - rus
PT  - Journal Article
PL  - Russia (Federation)
TA  - Klin Med (Mosk)
JT  - Klinicheskaia meditsina
JID - 2985204R
SB  - IM
MH  - Bioethical Issues
MH  - *Ethical Theory
MH  - *Ethics, Medical
MH  - Humanism
MH  - Humans
MH  - Patient Rights/*ethics
EDAT- 2012/10/30 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/10/30 06:00
PHST- 2012/10/30 06:00 [entrez]
PHST- 2012/10/30 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
PST - ppublish
SO  - Klin Med (Mosk). 2012;90(8):69-72.


PMID- 23101139
OWN - NLM
STAT- MEDLINE
DCOM- 20130125
LR  - 20211021
IS  - 1470-2118 (Print)
IS  - 1470-2118 (Linking)
VI  - 12
IP  - 5
DP  - 2012 Oct
TI  - Genomic medicine: challenges and opportunities for physicians.
PG  - 416-9
AB  - Medicine has always striven to personalise or stratify approaches towards
      individual patients, but recently these terms have been applied particularly to
      denote improved disease sub-classification achieved through new genetic and
      genomic technologies. Techniques to analyse a person's genetic code have improved
      in sensitivity exponentially over recent years and at the same time the cost of
      such analyses has become affordable to routine NHS care. This article highlights 
      the significant opportunities that genomics brings to healthcare, as well as some
      of the practical and ethical challenges.
FAU - Burton, H
AU  - Burton H
AD  - Foundation for Genomics and Population Health, Cambridge.
FAU - Cole, T
AU  - Cole T
FAU - Lucassen, A M
AU  - Lucassen AM
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Med (Lond)
JT  - Clinical medicine (London, England)
JID - 101092853
SB  - IM
EIN - Clin Med. 2012 Dec;12(6):504
MH  - Education, Medical
MH  - *Genetic Diseases, Inborn/diagnosis/therapy
MH  - Genetic Predisposition to Disease
MH  - *Genomics/ethics
MH  - Humans
MH  - *Precision Medicine
MH  - State Medicine/organization & administration/*trends
MH  - United Kingdom
PMC - PMC4953761
EDAT- 2012/10/30 06:00
MHDA- 2013/01/26 06:00
CRDT- 2012/10/30 06:00
PHST- 2012/10/30 06:00 [entrez]
PHST- 2012/10/30 06:00 [pubmed]
PHST- 2013/01/26 06:00 [medline]
AID - 10.7861/clinmedicine.12-5-416 [doi]
PST - ppublish
SO  - Clin Med (Lond). 2012 Oct;12(5):416-9. doi: 10.7861/clinmedicine.12-5-416.


PMID- 23100059
OWN - NLM
STAT- MEDLINE
DCOM- 20131104
LR  - 20191210
IS  - 1439-359X (Electronic)
IS  - 0939-7248 (Linking)
VI  - 23
IP  - 2
DP  - 2013 Apr
TI  - Long-term catch-up weight gain following fundoplication in children.
PG  - 121-6
LID - 10.1055/s-0032-1324801 [doi]
AB  - BACKGROUND: Laparoscopic fundoplication for severe gastroesophageal reflux (GOR) 
      is well established in children. However, there are only a few reports on the
      long-term nutritional outcome following fundoplication. The aim of this study was
      to assess weight gain following fundoplication in children. METHODS: In this
      study, 127 children who underwent laparoscopic fundoplication +/- gastrostomy
      between July 1998 and April 2007 were followed up for a median of 29.6 months
      postsurgery. Data (demography, weight) at fundoplication were collected
      prospectively, with ethical approval. Weights were converted to Z-scores for age 
      (Z-score of 0 is equivalent to 50th percentile, -1 to 16th centile, and -2.0 is
      equivalent to 2nd centile). Severe failure to thrive (FTT) was defined as a
      Z-score of less than or equal to -2. Data were compared using the two-tailed
      Student t test, and multilevel regression modeling was applied. RESULTS: At the
      time of operation, patients had a low weight-for-age Z-score (-1.87 +/- 0.19) and
      61 children (48%) had FTT. Children who received a simultaneous gastrostomy had a
      significantly lower Z-score at operation (-2.80 +/- 0.22) than those who did not 
      (-0.68 +/- 0.25, p < 0.001). Overall, patients exhibited significant catch-up
      weight gain following surgery (+0.88 +/- 0.14, p < 0.001). The greatest increase 
      in weight was mostly marked in patients who had a gastrostomy inserted (+1.22 +/-
      0.20, p < 0.001), but it was also significant in patients who did not receive a
      gastrostomy (+0.44 +/- 0.17, p = 0.013). Catch-up weight gain occurred in
      neurologically impaired (NI) patients with (+1.31 +/- 0.22, p < 0.001) or without
      (+0.81 +/- 0.29, p = 0.012) gastrostomy. Weight of neurologically normal (NN)
      patients was within normal range but slightly lower than average before surgery
      (-0.45 +/- 0.24) and this did not significantly change following surgery. There
      was no significant catch-up weight gain in patients (n = 9) with "esophageal
      pathologies" (Z-score of -1.35 +/- 0.61 at operation compared with -0.35 +/- 0.34
      at follow-up; p = 0.14). CONCLUSIONS: Laparoscopic fundoplication (with or
      without gastrostomy placement) resulted in significant weight gain in children
      with GOR. Insertion of a gastrostomy at the same time resulted in greater weight 
      gain. Pronounced weight gain occurred in NI children, whereas NN children and
      those with esophageal pathologies did not demonstrate any significant benefit in 
      terms of weight gain following fundoplication.
CI  - Georg Thieme Verlag KG Stuttgart . New York.
FAU - Kubiak, Rainer
AU  - Kubiak R
AD  - Department of Paediatric Surgery, Oxford University Hospital, Oxford, United
      Kingdom. rainerkubiak@hotmail.com
FAU - Eaton, Simon
AU  - Eaton S
FAU - Andrews, James
AU  - Andrews J
FAU - Grant, Hugh W
AU  - Grant HW
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20121025
PL  - United States
TA  - Eur J Pediatr Surg
JT  - European journal of pediatric surgery : official journal of Austrian Association 
      of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie
JID - 9105263
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Esophageal Atresia/complications
MH  - Failure to Thrive/etiology
MH  - Female
MH  - Follow-Up Studies
MH  - *Fundoplication/methods
MH  - Gastroesophageal Reflux/complications/*surgery
MH  - Gastrostomy
MH  - Hernia, Diaphragmatic/complications
MH  - Hernias, Diaphragmatic, Congenital
MH  - Humans
MH  - Infant
MH  - Laparoscopy
MH  - Male
MH  - Nervous System Diseases/complications
MH  - Regression Analysis
MH  - Treatment Outcome
MH  - *Weight Gain
EDAT- 2012/10/27 06:00
MHDA- 2013/11/05 06:00
CRDT- 2012/10/27 06:00
PHST- 2012/10/27 06:00 [entrez]
PHST- 2012/10/27 06:00 [pubmed]
PHST- 2013/11/05 06:00 [medline]
AID - 10.1055/s-0032-1324801 [doi]
PST - ppublish
SO  - Eur J Pediatr Surg. 2013 Apr;23(2):121-6. doi: 10.1055/s-0032-1324801. Epub 2012 
      Oct 25.


PMID- 23100058
OWN - NLM
STAT- MEDLINE
DCOM- 20130806
LR  - 20191210
IS  - 1439-359X (Electronic)
IS  - 0939-7248 (Linking)
VI  - 23
IP  - 1
DP  - 2013 Feb
TI  - Stapled bowel anastomoses in newborn surgery.
PG  - 63-6
LID - 10.1055/s-0032-1326952 [doi]
AB  - BACKGROUND: In this work, we have described our experience with repair of bowel
      discontinuity by applying stapled anastomosis. The aim of this study was to
      compare two basic intestinal anastomotic techniques and to establish the
      feasibility of the stapled connection of bowel in neonates and infants. METHODS: 
      Between August 2009 and December 2011, we have performed 23 cases of hand-sewn
      anastomosis (group I) and 21 cases of mechanical anastomosis (group II) in
      children during the first 3 months of life. The standard hand technique was
      typically fashioned by continuous two-layer absorbable suture. A stapled
      anastomosis was accomplished using the linear endoscopic stapler with 2.5-mm
      staples (Ethicon Endo-Surgery, Cincinnati, Ohio, United States). The two groups
      were compared for patients' demographics, operative report, and postoperative
      outcomes. RESULTS: There were no differences in the preoperative parameters
      between the two groups regarding age before surgery, and body weight at
      operation. The "hand" group and "stapler" group had similar mean preoperative age
      (19.7 vs. 23.2 days; p = 0.096) and average weight (2884.3 vs. 2716.0 g; p =
      0.692). The mean operative time for bowel continuity restoration in group I was
      77.4 minutes. In contrast, the mean duration of the operation in the group II was
      56.4 minutes. The differences between groups were statistically significant (p < 
      0.0001). The mean time of full enteral feeding for patients with mechanical
      anastomosis was isochronous for patients with standard hand-sewn technique (6.7
      vs. 6.7 days; p = 0.926). The statistically identical postoperative hospital stay
      was registered in patients of both groups (13.3 vs. 14.1 days; p = 0.852). The
      postoperative course was uneventful in all the patients. All the anastomoses were
      fully functional at the end of the study. CONCLUSION: Efficacy of the stapled
      anastomosis was confirmed by the shorter time of operation with saving of equal
      time of full enteral feeding and hospitalization.
CI  - Georg Thieme Verlag KG Stuttgart . New York.
FAU - Kozlov, Yury
AU  - Kozlov Y
AD  - Department of Newborn Surgery, Pediatric Hospital, Irkutsk, Russian Federation.
      yuriherz@hotmail.com
FAU - Novogilov, Vladimir
AU  - Novogilov V
FAU - Podkamenev, Alexey
AU  - Podkamenev A
FAU - Weber, Irina
AU  - Weber I
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
DEP - 20121025
PL  - United States
TA  - Eur J Pediatr Surg
JT  - European journal of pediatric surgery : official journal of Austrian Association 
      of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie
JID - 9105263
SB  - IM
MH  - Anastomosis, Surgical/instrumentation/methods
MH  - Enteral Nutrition
MH  - Feasibility Studies
MH  - Follow-Up Studies
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Intestinal Diseases/*surgery
MH  - Intestines/*surgery
MH  - Length of Stay
MH  - Operative Time
MH  - Recovery of Function
MH  - Retrospective Studies
MH  - Surgical Staplers
MH  - *Surgical Stapling/instrumentation/methods
EDAT- 2012/10/27 06:00
MHDA- 2013/08/07 06:00
CRDT- 2012/10/27 06:00
PHST- 2012/10/27 06:00 [entrez]
PHST- 2012/10/27 06:00 [pubmed]
PHST- 2013/08/07 06:00 [medline]
AID - 10.1055/s-0032-1326952 [doi]
PST - ppublish
SO  - Eur J Pediatr Surg. 2013 Feb;23(1):63-6. doi: 10.1055/s-0032-1326952. Epub 2012
      Oct 25.


PMID- 23099799
OWN - NLM
STAT- MEDLINE
DCOM- 20130926
LR  - 20211021
IS  - 1525-1497 (Electronic)
IS  - 0884-8734 (Linking)
VI  - 28
IP  - 4
DP  - 2013 Apr
TI  - A systematic review of communication quality improvement interventions for
      patients with advanced and serious illness.
PG  - 570-7
LID - 10.1007/s11606-012-2204-4 [doi]
AB  - BACKGROUND: Effective communication is an interaction between two or more people 
      that produces a desired effect and is a key element of quality of care for
      patients with advanced and serious illness and their family members. Suboptimal
      provider-patient/family communication is common, with negative effects on
      patient/family-centered outcomes. OBJECTIVES: To systematically review the
      evidence for effectiveness of communication-related quality improvement
      interventions for patients with advanced and serious illness and to explore the
      effectiveness of consultative and integrative interventions. DATA SOURCES:
      MEDLINE, CINAHL, PsycINFO, Cochrane, and DARE from 2000 through December 2011 and
      reference list of eligible articles and reviews. STUDY ELIGIBILITY CRITERIA,
      PARTICIPANTS AND INTERVENTIONS: Prospective, controlled quality improvement
      studies in populations with life-limiting or severe life-threatening illness with
      a primary intervention focus of improving communication with patients and/or
      families. STUDY APPRAISAL AND SYNTHESIS METHODS: Two investigators independently 
      screened and abstracted data on patient/family-centered outcomes. RESULTS: We
      included 20 studies; 13 (65 %) were in intensive care. We found four intervention
      types: (1) family meetings with the usual team (11 studies, 77 % found
      improvement in healthcare utilization), (2) palliative care teams (5 studies, 50 
      % found improvement in healthcare utilization), (3) ethics consultation (2
      studies, 100 % found improvement in healthcare utilization), and (4)
      physician-patient communication (2 studies, no significant improvement in
      healthcare utilization). Among studies addressing the outcomes of patient/family 
      satisfaction, 22 % found improvement; among studies addressing healthcare
      utilization (e.g., length of stay), 73 % found improvement. Results suggest that 
      consultative interventions, as opposed to integrative ones, may be more
      effective, but more research is needed. LIMITATIONS: Study heterogeneity did not 
      allow quantitative synthesis. CONCLUSIONS AND IMPLICATIONS OF KEY FINDINGS:
      Communication in the care of patients with advanced and serious illness can be
      improved using quality improvement interventions, particularly for healthcare
      utilization as an outcome. Interventions may be more effective using a
      consultative approach.
FAU - Fawole, Oluwakemi A
AU  - Fawole OA
AD  - Johns Hopkins University Evidence-Based Practice Center, 1830 East Monument
      Street, Room 8065, Baltimore, MD 21287, USA. ofawole1@jhmi.edu
FAU - Dy, Sydney M
AU  - Dy SM
FAU - Wilson, Renee F
AU  - Wilson RF
FAU - Lau, Brandyn D
AU  - Lau BD
FAU - Martinez, Kathryn A
AU  - Martinez KA
FAU - Apostol, Colleen C
AU  - Apostol CC
FAU - Vollenweider, Daniela
AU  - Vollenweider D
FAU - Bass, Eric B
AU  - Bass EB
FAU - Aslakson, Rebecca A
AU  - Aslakson RA
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PT  - Systematic Review
DEP - 20121026
PL  - United States
TA  - J Gen Intern Med
JT  - Journal of general internal medicine
JID - 8605834
SB  - IM
MH  - *Communication
MH  - Critical Care/standards
MH  - Delivery of Health Care/statistics & numerical data
MH  - Humans
MH  - Palliative Care/*standards
MH  - Patient Satisfaction
MH  - Professional-Family Relations
MH  - *Professional-Patient Relations
MH  - *Quality Improvement
PMC - PMC3599019
EDAT- 2012/10/27 06:00
MHDA- 2013/09/27 06:00
CRDT- 2012/10/27 06:00
PHST- 2012/04/20 00:00 [received]
PHST- 2012/07/23 00:00 [accepted]
PHST- 2012/07/19 00:00 [revised]
PHST- 2012/10/27 06:00 [entrez]
PHST- 2012/10/27 06:00 [pubmed]
PHST- 2013/09/27 06:00 [medline]
AID - 10.1007/s11606-012-2204-4 [doi]
PST - ppublish
SO  - J Gen Intern Med. 2013 Apr;28(4):570-7. doi: 10.1007/s11606-012-2204-4. Epub 2012
      Oct 26.


PMID- 23099751
OWN - NLM
STAT- MEDLINE
DCOM- 20131127
LR  - 20190907
IS  - 1678-4561 (Electronic)
IS  - 1413-8123 (Linking)
VI  - 17
IP  - 10
DP  - 2012 Oct
TI  - [Healthcare needs, public policies and gender: the perspective of professional
      practices].
PG  - 2635-44
LID - S1413-81232012001000013 [pii]
AB  - This paper examines the relationship between public policies and professional
      practices with respect to healthcare needs. Taking a theoretical-conceptual
      approach, practices are defined as acts that are permeated by
      technical-scientific and socio-historical determinants for the social production 
      of work, and the possibilities for cultural, ethical and political changes were
      analyzed in order to take critical action regarding gender inequalities. With
      comprehensive healthcare for men as the reference point, the relevance of a
      distinction between male and female needs, as partial and not necessarily
      convergent realities in (re)producing these inequalities, is examined. Likewise, 
      professional practices are examined as partial and distinct realities of policies
      that establish non-immediate relationships. It is considered that the following
      are symbolic and practical obstacles to change: the reduction of needs through
      biomedical normalization; the culture of self-employment and approaches that
      individualize needs; the traditional gender-based culture that conserves unequal 
      practices for men and women; and the lack of registration of rights as part of
      professional action. This requires proposals specifically geared to healthcare
      practices and male needs, in order to achieve greater convergence with policy
      reforms.
FAU - Schraiber, Lilia Blima
AU  - Schraiber LB
AD  - Departamento de Medicina Preventiva, Faculdade de Medicina, Universidade de Sao
      Paulo, Brazil. liliabli@usp.br
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Necessidades de saude, politicas publicas e genero: a perspectiva das praticas
      profissionais.
PL  - Brazil
TA  - Cien Saude Colet
JT  - Ciencia & saude coletiva
JID - 9713483
SB  - IM
MH  - Brazil
MH  - Female
MH  - Health Services Needs and Demand/*statistics & numerical data
MH  - Humans
MH  - Male
MH  - *Professional Practice
MH  - *Public Policy
MH  - Sex Factors
EDAT- 2012/10/27 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/10/27 06:00
PHST- 2012/06/15 00:00 [received]
PHST- 2012/07/01 00:00 [accepted]
PHST- 2012/10/27 06:00 [entrez]
PHST- 2012/10/27 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - S1413-81232012001000013 [pii]
AID - 10.1590/s1413-81232012001000013 [doi]
PST - ppublish
SO  - Cien Saude Colet. 2012 Oct;17(10):2635-44. doi: 10.1590/s1413-81232012001000013.


PMID- 23099609
OWN - NLM
STAT- MEDLINE
DCOM- 20140220
LR  - 20220318
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 9
IP  - 4
DP  - 2012 Oct-Dec
TI  - Pathologising alternate sexuality: shifting psychiatric practices and a need for 
      ethical norms and reforms.
PG  - 291-2
FAU - Kalra, Gurvinder
AU  - Kalra G
AD  - Assistant Professor of Psychiatry, MGM University of Health Sciences, Kamothe,
      Navi Mumbai 410 209 INDIA e-mail: kalragurvinder@gmail.com.
LA  - eng
PT  - Letter
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - *Homosexuality, Male
MH  - Humans
MH  - India
MH  - Male
MH  - Medicalization/*ethics
MH  - Psychiatry/*ethics
EDAT- 2012/10/27 06:00
MHDA- 2014/02/22 06:00
CRDT- 2012/10/27 06:00
PHST- 2012/10/27 06:00 [entrez]
PHST- 2012/10/27 06:00 [pubmed]
PHST- 2014/02/22 06:00 [medline]
AID - http://ijme.in/204lt289.html [pii]
AID - 10.20529/IJME.2012.101 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2012 Oct-Dec;9(4):291-2. doi: 10.20529/IJME.2012.101.


PMID- 23099608
OWN - NLM
STAT- MEDLINE
DCOM- 20140220
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 9
IP  - 4
DP  - 2012 Oct-Dec
TI  - Ethical aspects of operating on seropositive patients.
PG  - 290-1
FAU - Prakash, Prabhu
AU  - Prakash P
AD  - Associate Professor, Department of Microbiology, Integrated Counseling and
      Testing Center, Dr. S.N Medical College, Jodhpur, Rajasthan INDIA.
FAU - Gupta, Ekta
AU  - Gupta E
FAU - Gupta, P C
AU  - Gupta PC
FAU - Rajpurohit, Vikas
AU  - Rajpurohit V
FAU - Mathur, Arvind
AU  - Mathur A
LA  - eng
PT  - Letter
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - HIV Infections/*prevention & control/transmission
MH  - Hepatitis B/*prevention & control/transmission
MH  - Hepatitis C/*prevention & control/transmission
MH  - Humans
MH  - India
MH  - Infection Control/organization & administration/standards
MH  - Infectious Disease Transmission, Patient-to-Professional/*prevention & control
MH  - Organizational Policy
MH  - Surgical Procedures, Operative/*ethics
EDAT- 2012/10/27 06:00
MHDA- 2014/02/22 06:00
CRDT- 2012/10/27 06:00
PHST- 2012/10/27 06:00 [entrez]
PHST- 2012/10/27 06:00 [pubmed]
PHST- 2014/02/22 06:00 [medline]
AID - http://ijme.in/204lt289.html [pii]
AID - 10.20529/IJME.2012.100 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2012 Oct-Dec;9(4):290-1. doi: 10.20529/IJME.2012.100.


PMID- 23099606
OWN - NLM
STAT- MEDLINE
DCOM- 20140220
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 9
IP  - 4
DP  - 2012 Oct-Dec
TI  - Ethics of pandemic planning in India.
PG  - 289
FAU - Borgohain, Sunny
AU  - Borgohain S
AD  - M Sc student, Jamsetji Tata Centre for Disaster Management, Tata Institute of
      Social Sciences, VN Purav Marg, Deonar, Mumbai 400 088 INDIA e-mail:
      sunnytiss@gmail.com.
LA  - eng
PT  - Letter
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - *Disaster Planning
MH  - Healthcare Disparities/*ethics
MH  - Humans
MH  - India/epidemiology
MH  - Influenza, Human/epidemiology/*prevention & control
MH  - Pandemics/*prevention & control
EDAT- 2012/10/27 06:00
MHDA- 2014/02/22 06:00
CRDT- 2012/10/27 06:00
PHST- 2012/10/27 06:00 [entrez]
PHST- 2012/10/27 06:00 [pubmed]
PHST- 2014/02/22 06:00 [medline]
AID - http://ijme.in/204lt289.html [pii]
AID - 10.20529/IJME.2012.098 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2012 Oct-Dec;9(4):289. doi: 10.20529/IJME.2012.098.


PMID- 23099605
OWN - NLM
STAT- MEDLINE
DCOM- 20140220
LR  - 20220311
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 9
IP  - 4
DP  - 2012 Oct-Dec
TI  - Patients rights in India: an ethical perspective.
PG  - 277-81
AB  - Patient autonomy is affected by a number of factors, including severity of
      illness, socio-economic status and dependence. Many patients find that they are
      not treated with due consideration and compassion, and also have no control over 
      their own care.
FAU - Ghooi, R B
AU  - Ghooi RB
AD  - Professor, Symbiosis School of Biomedical Sciences, Symbiosis International
      University, Lavale, Tal: Mulshi, Pune 412 115 INDIA e-mail:
      ravindra.ghooi@gmail.com.
FAU - Deshpande, S R
AU  - Deshpande SR
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Codes of Ethics/*legislation & jurisprudence
MH  - *Government Regulation
MH  - Humans
MH  - India
MH  - Patient Rights/*ethics/*legislation & jurisprudence
EDAT- 2012/10/27 06:00
MHDA- 2014/02/22 06:00
CRDT- 2012/10/27 06:00
PHST- 2012/10/27 06:00 [entrez]
PHST- 2012/10/27 06:00 [pubmed]
PHST- 2014/02/22 06:00 [medline]
AID - http://ijme.in/204cm277.html [pii]
AID - 10.20529/IJME.2012.092 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2012 Oct-Dec;9(4):277-81. doi: 10.20529/IJME.2012.092.


PMID- 23099604
OWN - NLM
STAT- MEDLINE
DCOM- 20140220
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 9
IP  - 4
DP  - 2012 Oct-Dec
TI  - Mainstreaming AYUSH: an ethical analysis.
PG  - 272-7
AB  - The National Rural Health Mission has stated as one of its key mandates the
      mainstreaming of the Ayurveda, Yoga, Naturopathy, Unani, Siddha and Homeopathy
      (AYUSH) systems in order to help solve the human resource shortage in Indian
      healthcare. This has been planned at the primary level by providing training to
      AYUSH practitioners on primary care and national health programmes; at the
      secondary level by establishing departments of AYUSH in the district and taluka
      level hospitals; and at the tertiary level by establishing AYUSH centres of
      excellence as referral centres, and research, development and supervision points.
      The practical challenges to be considered include a gross divergence in the basic
      philosophy of practice; disparities in approach to specific clinical conditions; 
      differences in their normative approach in decision making; an unclear policy for
      cross referral and problems of cross practice that could potentially rise in this
      condition. Mainstreaming of AYUSH into the existing public health system can have
      certain ethical implications: not doing good by failing to concentrate on the
      community value judgments about AYUSH; doing harm by a confusing plurality in
      approach and unhealthy segregation of practices without healthy dialogue between 
      practitioners of either system; not disclosing which type of practitioners (AYUSH
      or allopathy) the patient is seeing; lack of proper public accountability
      mechanisms at the primary care and grassroots levels; and, finally, lack of
      social justice. These ethical issues have to be considered while mainstreaming
      AYUSH.
FAU - Gopichandran, Vijayaprasad
AU  - Gopichandran V
AD  - Doctoral Research Fellow, School of Public Health, SRM University, Kanchipuram
      District, Tamil Nadu 603 203 INDIA e-mail: vijay.gopichandran@gmail.com.
FAU - Satish Kumar, Ch
AU  - Satish Kumar Ch
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Female
MH  - Homeopathy
MH  - Humans
MH  - India
MH  - Integrative Medicine/*ethics/*organization & administration
MH  - Male
MH  - Medicine, Ayurvedic
MH  - Medicine, Unani
MH  - *Patient Acceptance of Health Care
MH  - *Quality of Health Care
MH  - Social Justice
EDAT- 2012/10/27 06:00
MHDA- 2014/02/22 06:00
CRDT- 2012/10/27 06:00
PHST- 2012/10/27 06:00 [entrez]
PHST- 2012/10/27 06:00 [pubmed]
PHST- 2014/02/22 06:00 [medline]
AID - http://ijme.in/204cm270.html [pii]
AID - 10.20529/IJME.2012.091 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2012 Oct-Dec;9(4):272-7. doi: 10.20529/IJME.2012.091.


PMID- 23099602
OWN - NLM
STAT- MEDLINE
DCOM- 20140220
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 9
IP  - 4
DP  - 2012 Oct-Dec
TI  - Pre-employment medical testing in Brazil: ethical challenges.
PG  - 266-8
AB  - Pre-employment medical tests, considered to be a practice within the subspecialty
      of occupational medicine, are ordered by physicians on behalf of employers.
      Candidates for a job may be rejected if they are found to suffer from a condition
      that can be worsened by the job, or one that may put other workers at risk. As
      the physician who orders pre-employment tests is chosen by the employer,
      pre-employment tests can violate both the autonomy and the privacy of the
      individual. This paper discusses ethical conflicts inherent in pre-employment
      medical testing.
FAU - Palhares, Dario
AU  - Palhares D
AD  - University Hospital of Brasilia, SGAN 604, pronto-socorro, Brasilia, DF BRAZIL
      e-mail: dariompm@unb.br.
FAU - Laurentino dos Santos, Ivone
AU  - Laurentino dos Santos I
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Brazil
MH  - Confidentiality/ethics
MH  - Conflict of Interest
MH  - Genetic Testing/ethics
MH  - HIV Infections/prevention & control
MH  - Humans
MH  - Mass Screening/ethics
MH  - Occupational Medicine/*ethics
MH  - Personnel Selection/*ethics
MH  - Physician-Patient Relations/ethics
EDAT- 2012/10/27 06:00
MHDA- 2014/02/22 06:00
CRDT- 2012/10/27 06:00
PHST- 2012/10/27 06:00 [entrez]
PHST- 2012/10/27 06:00 [pubmed]
PHST- 2014/02/22 06:00 [medline]
AID - http://ijme.in/204cm266.html [pii]
AID - 10.20529/IJME.2012.089 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2012 Oct-Dec;9(4):266-8. doi: 10.20529/IJME.2012.089.


PMID- 23099599
OWN - NLM
STAT- MEDLINE
DCOM- 20140220
LR  - 20211021
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 9
IP  - 4
DP  - 2012 Oct-Dec
TI  - Review of multinational human subjects research: experience from the PHFI-Emory
      Center of Excellence partnership.
PG  - 255-8
AB  - Public Health Foundation of India (PHFI), New Delhi, India and Emory University, 
      Atlanta, USA, are lead partners in the National Heart, Lung and Blood
      Institute/UnitedHealth funded Center of Excellence (COE) in Cardio-metabolic Risk
      Reduction in South Asia which provides a vehicle for the development of
      collaborative research projects. With funding from the National Institutes of
      Health/ Fogarty International Center, a project was commenced to ensure seamless,
      thorough and efficient review of this collaborative research. The primary
      activities of the project are: 1) fact-finding activities which included conduct 
      of a case study and review of policies and procedures of the involved ethics
      review committees (ERCs); 2) training workshops for COE ERC members and staff and
      3) piloting of parallel review of continuing reviews and amendments. A process of
      parallel review of collaborative research has now been initiated and projects are
      now submitted simultaneously to the Emory institutional review board (IRB) and
      PHFI institutional ethics committee (IEC).
FAU - Somsekhar, Hemalatha
AU  - Somsekhar H
AD  - Public Health Foundation of India, ISID Campus, 4 Institutional Area, Vasant
      Kunj, New Delhi 110 070 INDIA.
FAU - Prabhakaran, Dorairaj
AU  - Prabhakaran D
FAU - Tandon, Nikhil
AU  - Tandon N
FAU - Rousselle, Rebecca
AU  - Rousselle R
FAU - Fisher, Sarah
AU  - Fisher S
FAU - Stein, Aryeh D
AU  - Stein AD
LA  - eng
GR  - S07 TW008847/TW/FIC NIH HHS/United States
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Ethics Committees, Research/*organization & administration
MH  - Georgia
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - India
MH  - *Interinstitutional Relations
MH  - *International Cooperation
MH  - Models, Organizational
MH  - Multicenter Studies as Topic/*ethics
MH  - Program Development
PMC - PMC3491753
MID - NIHMS416487
EDAT- 2012/10/27 06:00
MHDA- 2014/02/22 06:00
CRDT- 2012/10/27 06:00
PHST- 2012/10/27 06:00 [entrez]
PHST- 2012/10/27 06:00 [pubmed]
PHST- 2014/02/22 06:00 [medline]
AID - http://ijme.in/204cm255.html [pii]
AID - 10.20529/IJME.2012.086 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2012 Oct-Dec;9(4):255-8. doi: 10.20529/IJME.2012.086.


PMID- 23099597
OWN - NLM
STAT- MEDLINE
DCOM- 20140220
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 9
IP  - 4
DP  - 2012 Oct-Dec
TI  - Medical students' views on the migration of doctors: self-interest vs altruism.
PG  - 249-51
AB  - The migration of doctors from developing to developed countries is an ongoing
      phenomenon. There is scant information on the attitudes of medical students to
      the ethical aspects of this trend. This paper reports on a study of 50 first-year
      medical students and 52 interns in a college in Vellore city, Tamil Nadu. Only 13
      of 102 respondents thought that migrant doctors contributed significantly to the 
      health system in India. 17% thought that doctor migration was not an ethical
      issue, and 40% thought that individual altruism had no role in solving public
      problems. The responses to case scenarios suggest that first-year medical
      students are more likely to have an altruistic and communitarian attitude whereas
      interns tended to emphasise individual liberty and autonomy.
FAU - Tharakan, Lijo J
AU  - Tharakan LJ
AD  - Department of Community Health, Christian Medical College, Vellore 632 002 INDIA.
FAU - Elencheral, A L
AU  - Elencheral AL
FAU - Karthiga, M
AU  - Karthiga M
FAU - Kumaran, V
AU  - Kumaran V
FAU - Rakesh, P S
AU  - Rakesh PS
FAU - Gopichandran, Vijayprasad
AU  - Gopichandran V
FAU - John, Jacob
AU  - John J
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - *Altruism
MH  - *Attitude
MH  - Cross-Sectional Studies
MH  - Decision Making
MH  - *Emigration and Immigration
MH  - Female
MH  - Humans
MH  - India
MH  - Intention
MH  - Male
MH  - *Professional Practice Location
MH  - *Students, Medical
EDAT- 2012/10/27 06:00
MHDA- 2014/02/22 06:00
CRDT- 2012/10/27 06:00
PHST- 2012/10/27 06:00 [entrez]
PHST- 2012/10/27 06:00 [pubmed]
PHST- 2014/02/22 06:00 [medline]
AID - http://ijme.in/204ar249.html [pii]
AID - 10.20529/IJME.2012.084 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2012 Oct-Dec;9(4):249-51. doi: 10.20529/IJME.2012.084.


PMID- 23099596
OWN - NLM
STAT- MEDLINE
DCOM- 20140220
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 9
IP  - 4
DP  - 2012 Oct-Dec
TI  - A social media self-evaluation checklist for medical practitioners.
PG  - 245-8
AB  - Increasing numbers of medical practitioners and medical students are using online
      social and business-related networking websites such as Facebook, Doc2doc and
      LinkedIn. These rapidly evolving and growing social media have potential to
      promote public health by providing powerful instruments for communication and
      education. However, evidence is emerging from studies, legal cases, and media
      reports that the use of these new technologies is creating several ethical
      problems for medical practitioners as well as medical students. Improper online
      activities may harm not only individual reputations and careers, but also the
      medical profession as a whole, for example by breach of patient confidentiality, 
      defamation of colleagues and employers, undisclosed conflict of interests that
      bias the medical practitioner's medical advice, posting of advice/information
      without an evidence base, and infringement of copyright. We developed a
      self-evaluation checklist for medical practitioners using social media. The
      checklist addresses three key elements in the use of social media: personal
      information and accessibility, connections, and postings. It contains questions
      specifically formulated to evaluate a medical practitioner's social media
      profile, to prevent unintended, improper online activities and to promote
      professional online behaviour.
FAU - Visser, Benjamin J
AU  - Visser BJ
AD  - Academic Medical Center, University of Amsterdam, Meibergdreef 1105 AZ, Amsterdam
      THE NETHERLANDS e-mail: b.j.visser@amc.uva.nl.
FAU - Huiskes, Florian
AU  - Huiskes F
FAU - Korevaar, Daniel A
AU  - Korevaar DA
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Checklist
MH  - Confidentiality/ethics
MH  - *Ethics, Medical
MH  - Guidelines as Topic
MH  - Humans
MH  - India
MH  - Interprofessional Relations/ethics
MH  - Physician-Patient Relations/ethics
MH  - *Social Media
EDAT- 2012/10/27 06:00
MHDA- 2014/02/22 06:00
CRDT- 2012/10/27 06:00
PHST- 2012/10/27 06:00 [entrez]
PHST- 2012/10/27 06:00 [pubmed]
PHST- 2014/02/22 06:00 [medline]
AID - http://ijme.in/204ar245.html [pii]
AID - 10.20529/IJME.2012.083 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2012 Oct-Dec;9(4):245-8. doi: 10.20529/IJME.2012.083.


PMID- 23099595
OWN - NLM
STAT- MEDLINE
DCOM- 20140220
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 9
IP  - 4
DP  - 2012 Oct-Dec
TI  - Perceptions about training and knowledge of HIV/AIDS ethics among health care
      providers at teaching hospitals of a medical college in Karnataka, India.
PG  - 242-4
AB  - A cross sectional study was conducted to evaluate perceptions of HIV/AIDS ethics 
      among health care professionals at three associate hospitals of Kasturba Medical 
      College Mangalore. A total of 144 health care professionals were included, of
      which 106 (73.6%) were doctors and 38 (26.4%) were nurses.Only 52.8% of doctors
      and 56.6% of nurses agreed that they had received adequate training related to
      HIV data confidentiality. 85.8% of doctors and 76.3% of nurses perceived that
      they need additional training in HIV policies & procedures. With respect to
      rights of HIV-positive clients 92.5% of doctors and 84.2% of nurses felt the need
      for further training. 69% of doctors and 52.6% of nurses agreed that
      confidentiality could be breached in case of subpoena or other judicial
      processes. Only 68.4% nurses agreed that it is an offence to intentionally
      disclose HIV/AIDS confidential information to anyone who is not legally
      authorised.
FAU - Unnikrishnan, B
AU  - Unnikrishnan B
AD  - Professor and Head, Department of Community Medicine, Kasturba Medical College,
      Manipal University, Mangalore, Karnataka 575 001 INDIA.
FAU - Papanna, Mohan B
AU  - Papanna MB
FAU - Vaman, K
AU  - Vaman K
FAU - Nithin, K
AU  - Nithin K
FAU - Rekha, T
AU  - Rekha T
FAU - Prasanna Mithra, P
AU  - Prasanna Mithra P
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Adult
MH  - *Confidentiality/ethics/legislation & jurisprudence
MH  - Cross-Sectional Studies
MH  - Ethics, Clinical/*education
MH  - Female
MH  - *HIV Infections
MH  - Hospitals, Teaching
MH  - Humans
MH  - India
MH  - Male
MH  - Middle Aged
MH  - *Practice Patterns, Nurses'/ethics/legislation & jurisprudence
MH  - *Practice Patterns, Physicians'/ethics/legislation & jurisprudence
EDAT- 2012/10/27 06:00
MHDA- 2014/02/22 06:00
CRDT- 2012/10/27 06:00
PHST- 2012/10/27 06:00 [entrez]
PHST- 2012/10/27 06:00 [pubmed]
PHST- 2014/02/22 06:00 [medline]
AID - http://ijme.in/204ar242.html [pii]
AID - 10.20529/IJME.2012.082 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2012 Oct-Dec;9(4):242-4. doi: 10.20529/IJME.2012.082.


PMID- 23099594
OWN - NLM
STAT- MEDLINE
DCOM- 20140220
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 9
IP  - 4
DP  - 2012 Oct-Dec
TI  - Good epidemiology, good ethics: empirical and ethical dimensions of global public
      health.
PG  - 235-41
AB  - This paper examines the following ethically and epidemiologically relevant
      challenges, as yet neglected in public health ethics: how to distribute resources
      and health risks and benefits, how to define evidentiary criteria that justify
      public health interventions, and how to define terms in which programme goals,
      successes, and failures will be assessed and monitored. We illuminate critical
      intersections of empirical and ethical dimensions of public health work, drawing 
      upon three global public health interventions-inclusion of the Hepatitis B
      vaccine in the Universal Immunisation Programme, Universal Salt Iodisation, and
      the Global Polio Eradication Initiative-and suggest strategies for addressing and
      responding to them.
FAU - Rentmeester, Christy A
AU  - Rentmeester CA
AD  - Associate Professor, Centre for Health Policy and Ethics, Creighton University
      School of Medicine 2500 California Plaza, Omaha, Nebraska, 68178 USA e-mail:
      christyrentmeester@creighton.edu.
FAU - Dasgupta, Rajib
AU  - Dasgupta R
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
RN  - 0 (Sodium Chloride, Dietary)
RN  - 0 (iodized salt)
RN  - 9679TC07X4 (Iodine)
SB  - IM
MH  - *Epidemiologic Methods
MH  - Global Health
MH  - Health Care Rationing/*ethics/organization & administration
MH  - *Health Priorities
MH  - Health Promotion/*ethics/organization & administration
MH  - Hepatitis B/prevention & control
MH  - Humans
MH  - Immunization Programs/ethics/organization & administration
MH  - India
MH  - Iodine
MH  - Poliomyelitis/prevention & control
MH  - Public Health/*ethics
MH  - Sodium Chloride, Dietary
EDAT- 2012/10/27 06:00
MHDA- 2014/02/22 06:00
CRDT- 2012/10/27 06:00
PHST- 2012/10/27 06:00 [entrez]
PHST- 2012/10/27 06:00 [pubmed]
PHST- 2014/02/22 06:00 [medline]
AID - http://ijme.in/204ar235.html [pii]
AID - 10.20529/IJME.2012.081 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2012 Oct-Dec;9(4):235-41. doi: 10.20529/IJME.2012.081.


PMID- 23099569
OWN - NLM
STAT- MEDLINE
DCOM- 20121231
LR  - 20121026
IS  - 1538-7488 (Electronic)
IS  - 0002-936X (Linking)
VI  - 112
IP  - 11
DP  - 2012 Nov
TI  - Ethical writing.
PG  - 12
LID - 10.1097/01.NAJ.0000422234.32932.97 [doi]
FAU - Harding, Andrew D
AU  - Harding AD
LA  - eng
PT  - Letter
PL  - United States
TA  - Am J Nurs
JT  - The American journal of nursing
JID - 0372646
SB  - IM
MH  - *Authorship
MH  - Humans
MH  - Nursing Research/*ethics
MH  - Publishing/*ethics
EDAT- 2012/10/27 06:00
MHDA- 2013/01/01 06:00
CRDT- 2012/10/27 06:00
PHST- 2012/10/27 06:00 [entrez]
PHST- 2012/10/27 06:00 [pubmed]
PHST- 2013/01/01 06:00 [medline]
AID - 10.1097/01.NAJ.0000422234.32932.97 [doi]
AID - 00000446-201211000-00004 [pii]
PST - ppublish
SO  - Am J Nurs. 2012 Nov;112(11):12. doi: 10.1097/01.NAJ.0000422234.32932.97.


PMID- 23099546
OWN - NLM
STAT- MEDLINE
DCOM- 20130524
LR  - 20121120
IS  - 1533-404X (Electronic)
IS  - 0195-7910 (Linking)
VI  - 33
IP  - 4
DP  - 2012 Dec
TI  - Debates about assisted suicide in Switzerland.
PG  - 410-3
LID - 10.1097/PAF.0b013e318273b83f [doi]
AB  - Assisted suicide is allowed in 3 states of the United States (Oregon, Washington,
      Montana) but only if performed by a physician.On the opposite, in Switzerland, at
      the beginning of the 20th century, the Swiss Penal Code referred to assisted
      suicide in the context of honor or an unhappy love affair. It was only in 1985
      that Exit Deutsche Schweiz (Exit for German-speaking Switzerland) "medically"
      assisted the first patient to end his life.Even if authorized by the Swiss law
      upon certain conditions, assisted suicide is subject to debates for ethical
      reasons. The Swiss Academy of Medical Sciences described directives to guide
      physicians on this difficult subject.Different studies showed an increase in the 
      number of medical-assisted suicide in Switzerland since the 1990s. Now, this
      number seems to be quite stable. Assisted suicide is authorized in a few
      hospitals under strict conditions (especially when returning home is
      impossible).Thus, according to the Swiss law, any person could perform assisted
      suicide; this is essentially performed by 3 main associations, using
      pentobarbital on medical prescription as lethal substance.Generally speaking, the
      Swiss population is rather in favor of assisted suicide. Among politics, the
      debate has been tough until 2010, when the Federal Council decided not to modify 
      the Swiss Penal Code concerning assisted suicide.
FAU - Burkhardt, Sandra
AU  - Burkhardt S
AD  - University Center of Legal Medicine, Geneva, Switzerland.
      sandra.burkhardt@hcuge.ch
FAU - La Harpe, Romano
AU  - La Harpe R
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Am J Forensic Med Pathol
JT  - The American journal of forensic medicine and pathology
JID - 8108948
SB  - IM
MH  - Attitude of Health Personnel
MH  - Codes of Ethics
MH  - Humans
MH  - Organizations, Nonprofit
MH  - Physician's Role
MH  - Politics
MH  - Public Opinion
MH  - Right to Die
MH  - Societies, Medical
MH  - Suicide, Assisted/*ethics/*legislation & jurisprudence
MH  - Switzerland
EDAT- 2012/10/27 06:00
MHDA- 2013/05/28 06:00
CRDT- 2012/10/27 06:00
PHST- 2012/10/27 06:00 [entrez]
PHST- 2012/10/27 06:00 [pubmed]
PHST- 2013/05/28 06:00 [medline]
AID - 10.1097/PAF.0b013e318273b83f [doi]
PST - ppublish
SO  - Am J Forensic Med Pathol. 2012 Dec;33(4):410-3. doi:
      10.1097/PAF.0b013e318273b83f.


PMID- 23099201
OWN - NLM
STAT- MEDLINE
DCOM- 20130709
LR  - 20161125
IS  - 1872-7727 (Electronic)
IS  - 0720-048X (Linking)
VI  - 82
IP  - 1
DP  - 2013 Jan
TI  - Patients' survival in lung malignancies treated by microwave ablation: our
      experience on 56 patients.
PG  - 177-81
LID - 10.1016/j.ejrad.2012.08.024 [doi]
LID - S0720-048X(12)00459-7 [pii]
AB  - OBJECTIVES: We retrospectively evaluated percutaneous CT-guided microwave (MW)
      ablation safety and efficacy in unresectable lung malignancies focusing on
      patients' survival. MATERIALS AND METHODS: All procedures were approved by the
      hospital ethical committee. From 2008 to 2012 we treated 69 unresectable lesions 
      (44 lung cancer, 25 lung metastases) in 56 patients (35 men/21 women; mean age:
      61.5 years). Treatment was performed under CT guidance using 14 G needles with a 
      3 cm active tip and a 55 W MW generator (Vivawave Microwave Coagulation System;
      Valley Lab). Treatment was performed at 45 W for 6-10 min. Patients were
      scheduled for a 3 and 6 month CT follow-up to evaluate lesion diameter and
      enhancement. Survival rate was evaluated by Kaplan-Meier analysis. RESULTS:
      Ablation procedures were completed according to protocol in all patients.
      Pneumothorax occurred in 18 patients and 8 required chest tube. Four lesions (all
      >4.3 cm) were retreated 20 days after the ablation because of peripheral focal
      areas of residual tumor. Follow-up CT evaluation showed a decrease in maximum
      diameter in 44/69 lesions (64%) and in 42/59 lesions (71%) at 3 and 6 months,
      respectively. In all cases no pathologic enhancement was observed.
      Cancer-specific mortality yielded a survival rate of 69% at 12 months, 54% at 24 
      months and 49% at 36 months, respectively. An estimate mean for survival time was
      27.8 months with a standard error of 2.8 months (95% confidence interval:
      22.4-33.2 months). CONCLUSION: Based on our experience, MW ablation seems to
      represent a potential safe and effective percutaneous technique in the treatment 
      of lung malignancies. MW ablation may improve survival in patients not suitable
      to surgery.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Belfiore, G
AU  - Belfiore G
AD  - Department of Diagnostic Imaging, "S. Anna-S. Sebastiano" Hospital, Via F.
      Palasciano, 81100 Caserta, Italy.
FAU - Ronza, F
AU  - Ronza F
FAU - Belfiore, M P
AU  - Belfiore MP
FAU - Serao, N
AU  - Serao N
FAU - di Ronza, G
AU  - di Ronza G
FAU - Grassi, R
AU  - Grassi R
FAU - Rotondo, A
AU  - Rotondo A
LA  - eng
PT  - Journal Article
DEP - 20121023
PL  - Ireland
TA  - Eur J Radiol
JT  - European journal of radiology
JID - 8106411
SB  - IM
MH  - Ablation Techniques/*mortality
MH  - Female
MH  - Humans
MH  - Italy/epidemiology
MH  - Lung Neoplasms/diagnostic imaging/*mortality/*surgery
MH  - Male
MH  - Microwaves/*therapeutic use
MH  - Middle Aged
MH  - Postoperative Complications/*mortality
MH  - Prevalence
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Surgery, Computer-Assisted/*mortality
MH  - Survival Analysis
MH  - Survival Rate
MH  - Tomography, X-Ray Computed/*statistics & numerical data
EDAT- 2012/10/27 06:00
MHDA- 2013/07/10 06:00
CRDT- 2012/10/27 06:00
PHST- 2012/04/23 00:00 [received]
PHST- 2012/07/15 00:00 [revised]
PHST- 2012/08/03 00:00 [accepted]
PHST- 2012/10/27 06:00 [entrez]
PHST- 2012/10/27 06:00 [pubmed]
PHST- 2013/07/10 06:00 [medline]
AID - S0720-048X(12)00459-7 [pii]
AID - 10.1016/j.ejrad.2012.08.024 [doi]
PST - ppublish
SO  - Eur J Radiol. 2013 Jan;82(1):177-81. doi: 10.1016/j.ejrad.2012.08.024. Epub 2012 
      Oct 23.


PMID- 23099025
OWN - NLM
STAT- MEDLINE
DCOM- 20131118
LR  - 20121116
IS  - 1769-6682 (Electronic)
IS  - 1297-9589 (Linking)
VI  - 40
IP  - 11
DP  - 2012 Nov
TI  - [Oocyte vitrification and its impact on the clinical practice of assisted
      reproduction].
PG  - 687-90
LID - 10.1016/j.gyobfe.2012.09.016 [doi]
LID - S1297-9589(12)00285-8 [pii]
AB  - Oocyte vitrification is a new technique in cryobiology that will lead to a number
      of improvements in assisted reproduction practices, oocyte donation and the
      preservation of female fertility. Professionals already versed in the techniques 
      of micromanipulation will be able to master the new procedures, which should not 
      be delegated to unqualified staff. When adopted by clinical units, oocyte
      vitrification will require changes in laboratory and administrative organization.
      The technique will also modify the ethical outlines of reproductive biology.
      France today is running behind in the application of this major development in
      cryobiology. The reasons are many and have to do with a long waiting period for
      authorization from national health authorities, a lack of material and human
      resources and a foreseeable shake-up in the nationally established egg donation
      program. However, recently a new law of bioethics has recognized the breakthrough
      that this new technique represents by allowing couples covered by the French
      national health care program for Assisted Reproductive Technologies (ART) to
      choose oocyte vitrification as an option.
CI  - Copyright (c) 2012 Elsevier Masson SAS. All rights reserved.
FAU - Boyer, P
AU  - Boyer P
AD  - Service de medecine et biologie de la reproduction, hopital
      Saint-Joseph-de-Marseille, 26, boulevard de Louvain, 13008 Marseille, France.
      pb.boyer@gmail.com
FAU - Tourame, P
AU  - Tourame P
FAU - Gervoise-Boyer, M
AU  - Gervoise-Boyer M
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - La vitrification des ovocytes et les changements induits dans nos pratiques
      d'AMP.
DEP - 20121023
PL  - France
TA  - Gynecol Obstet Fertil
JT  - Gynecologie, obstetrique & fertilite
JID - 100936305
SB  - IM
MH  - *Cryopreservation/economics/methods
MH  - Female
MH  - Fertility Preservation
MH  - France
MH  - Humans
MH  - National Health Programs
MH  - Oocyte Donation
MH  - Oocytes/*physiology
MH  - *Reproductive Techniques, Assisted/economics/legislation & jurisprudence
EDAT- 2012/10/27 06:00
MHDA- 2013/11/19 06:00
CRDT- 2012/10/27 06:00
PHST- 2012/05/30 00:00 [received]
PHST- 2012/09/14 00:00 [accepted]
PHST- 2012/10/27 06:00 [entrez]
PHST- 2012/10/27 06:00 [pubmed]
PHST- 2013/11/19 06:00 [medline]
AID - S1297-9589(12)00285-8 [pii]
AID - 10.1016/j.gyobfe.2012.09.016 [doi]
PST - ppublish
SO  - Gynecol Obstet Fertil. 2012 Nov;40(11):687-90. doi: 10.1016/j.gyobfe.2012.09.016.
      Epub 2012 Oct 23.


PMID- 23098912
OWN - NLM
STAT- MEDLINE
DCOM- 20130826
LR  - 20220409
IS  - 1552-5279 (Electronic)
IS  - 1552-5260 (Linking)
VI  - 9
IP  - 2
DP  - 2013 Mar
TI  - Current knowledge and future directions about the disclosure of dementia: a
      systematic review of the first decade of the 21st century.
PG  - e74-88
LID - 10.1016/j.jalz.2012.02.006 [doi]
LID - S1552-5260(12)00082-9 [pii]
AB  - BACKGROUND: The disclosure of Alzheimer's disease presents a great challenge
      because it entails emotionally charged communication about a life-threatening,
      incurable, and stigmatized disease. Although a broad consensus has evolved
      regarding the potential benefits of early disclosure of the diagnosis, little is 
      known about how these recommendations are actually implemented, and there is
      limited published research about the process issues of the disclosure. PURPOSE:
      (1) To systematically obtain and evaluate the relevant literature on disclosing a
      diagnosis of dementia, with special attention to process issues, and (2) to
      summarize current research findings and draw conclusions for future research and 
      clinical care in this area. METHODS: A systematic review of the literature on
      disclosure of dementia during the first decade of the 21st century was conducted.
      RESULTS: From 265 articles retrieved, 47 were included in the review. Although
      the studies published in the first years of the decade were concerned with
      assessing attitudes and preferences of those involved in the process of
      disclosing the diagnosis, those of the last years have focused more on
      communication and other process issues. CONCLUSIONS: A conceptual development
      over time in the area is observed in which in the first years, thought processes 
      begin as an ethical debate among clinicians and researchers about the topic of
      "truth telling" and dementia, continue as a search of the opinions of those
      involved in the process of disclosure about truth telling, and evolve (observed
      more recently) into an examination of how this truth telling is delivered.
CI  - Copyright (c) 2013 The Alzheimer's Association. Published by Elsevier Inc. All
      rights reserved.
FAU - Werner, Perla
AU  - Werner P
AD  - Department of Gerontology, University of Haifa, Mount Carmel, Haifa, Israel.
      werner@research.haifa.ac.il
FAU - Karnieli-Miller, Orit
AU  - Karnieli-Miller O
FAU - Eidelman, Shmuel
AU  - Eidelman S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20121024
PL  - United States
TA  - Alzheimers Dement
JT  - Alzheimer's & dementia : the journal of the Alzheimer's Association
JID - 101231978
SB  - IM
MH  - Communication
MH  - Dementia/*diagnosis
MH  - Humans
MH  - Physician-Patient Relations
MH  - *Truth Disclosure
EDAT- 2012/10/27 06:00
MHDA- 2013/08/27 06:00
CRDT- 2012/10/27 06:00
PHST- 2011/08/02 00:00 [received]
PHST- 2012/02/16 00:00 [revised]
PHST- 2012/02/29 00:00 [accepted]
PHST- 2012/10/27 06:00 [entrez]
PHST- 2012/10/27 06:00 [pubmed]
PHST- 2013/08/27 06:00 [medline]
AID - S1552-5260(12)00082-9 [pii]
AID - 10.1016/j.jalz.2012.02.006 [doi]
PST - ppublish
SO  - Alzheimers Dement. 2013 Mar;9(2):e74-88. doi: 10.1016/j.jalz.2012.02.006. Epub
      2012 Oct 24.


PMID- 23098556
OWN - NLM
STAT- MEDLINE
DCOM- 20130530
LR  - 20211021
IS  - 1756-0500 (Electronic)
IS  - 1756-0500 (Linking)
VI  - 5
DP  - 2012 Oct 25
TI  - Surgical management of inguinal hernias at Bugando Medical Centre in northwestern
      Tanzania: our experiences in a resource-limited setting.
PG  - 585
LID - 10.1186/1756-0500-5-585 [doi]
AB  - BACKGROUND: Inguinal hernia repair remains the commonest operation performed by
      general surgeons all over the world. There is paucity of published data on
      surgical management of inguinal hernias in our environment. This study is
      intended to describe our own experiences in the surgical management of inguinal
      hernias and compare our results with that reported in literature. METHODS: A
      descriptive prospective study was conducted at Bugando Medical Centre in
      northwestern Tanzania. Ethical approval to conduct the study was obtained from
      relevant authorities before the commencement of the study. Statistical data
      analysis was done using SPSS software version 17.0. RESULTS: A total of 452
      patients with inguinal hernias were enrolled in the study. The median age of
      patients was 36 years (range 3 months to 78 years). Males outnumbered females by 
      a ratio of 36.7:1. This gender deference was statistically significant (P=0.003).
      Most patients (44.7%) presented late (more than five years of onset of hernia).
      Inguinoscrotal hernia (66.8%) was the commonest presentation. At presentation,
      208 (46.0%) patients had reducible hernia, 110 (24.3%) had irreducible hernia, 84
      (18.6%) and 50(11.1%) patients had obstructed and strangulated hernias
      respectively. The majority of patients (53.1%) had right sided inguinal hernia
      with a right-to-left ratio of 2.1: 1. Ninety-two (20.4%) patients had bilateral
      inguinal hernias. 296 (65.5%) patients had indirect hernia, 102 (22.6%) had
      direct hernia and 54 (11.9%) had both indirect and direct types (pantaloon
      hernia). All patients in this study underwent open herniorrhaphy. The majority of
      patients (61.5%) underwent elective herniorrhaphy under spinal anaesthesia
      (69.2%). Local anaesthesia was used in only 1.1% of cases. Bowel resection was
      required in 15.9% of patients. Modified Bassini's repair (79.9%) was the most
      common technique of posterior wall repair of the inguinal canal. Lichtenstein
      mesh repair was used in only one (0.2%) patient. Complication rate was 12.4% and 
      it was significantly higher in emergency herniorrhaphy than in elective
      herniorrhaphy (P=0.002). The median length of hospital stay was 8 days and it was
      significantly longer in patients with advanced age, delayed admission,
      concomitant medical illness, high ASA class, the need for bowel resection and in 
      those with surgical repair performed under general anesthesia (P<0.001).
      Mortality rate was 9.7%. Longer duration of symptoms, late hospitalization,
      coexisting disease, high ASA class, delayed operation, the need for bowel
      resection and presence of complications were found to be predictors of mortality 
      (P<0.001). CONCLUSION: Inguinal hernias continue to be a source of morbidity and 
      mortality in our centre. Early presentation and elective repair of inguinal
      hernias is pivotal in order to eliminate the morbidity and mortality associated
      with this very common problem.
FAU - Mabula, Joseph B
AU  - Mabula JB
AD  - Department of Surgery, Catholic University of Health and Allied Sciences-Bugando,
      Mwanza, Tanzania.
FAU - Chalya, Phillipo L
AU  - Chalya PL
LA  - eng
PT  - Journal Article
DEP - 20121025
PL  - England
TA  - BMC Res Notes
JT  - BMC research notes
JID - 101462768
SB  - IM
MH  - *Academic Medical Centers/economics
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Chi-Square Distribution
MH  - Child
MH  - Child, Preschool
MH  - *Developing Countries/economics
MH  - Elective Surgical Procedures
MH  - Female
MH  - Health Care Costs
MH  - Health Resources/economics
MH  - Health Services Accessibility/economics
MH  - Hernia, Inguinal/economics/mortality/*surgery
MH  - *Herniorrhaphy/adverse effects/economics/mortality
MH  - Humans
MH  - Infant
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Postoperative Complications/surgery
MH  - Prospective Studies
MH  - Reoperation
MH  - Risk Factors
MH  - Tanzania
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC3526506
EDAT- 2012/10/27 06:00
MHDA- 2013/06/01 06:00
CRDT- 2012/10/27 06:00
PHST- 2012/06/28 00:00 [received]
PHST- 2012/10/23 00:00 [accepted]
PHST- 2012/10/27 06:00 [entrez]
PHST- 2012/10/27 06:00 [pubmed]
PHST- 2013/06/01 06:00 [medline]
AID - 1756-0500-5-585 [pii]
AID - 10.1186/1756-0500-5-585 [doi]
PST - epublish
SO  - BMC Res Notes. 2012 Oct 25;5:585. doi: 10.1186/1756-0500-5-585.


PMID- 23098481
OWN - NLM
STAT- MEDLINE
DCOM- 20130418
LR  - 20190606
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Linking)
VI  - 13
IP  - 8
DP  - 2012
TI  - Knowledge and perceptions of cancer and cancer prevention among Malaysian
      traditional healers: a qualitative study.
PG  - 3841-50
AB  - OBJECTIVE: The objective of this study was to explore the knowledge and
      perceptions of Malaysian tradition healers towards cancer and cancer prevention. 
      METHODOLOGY: A total of 25 participants agreed to participate in this qualitative
      study during the period from 20th July 2011 until 24th of September 2011. The
      proposal of this study was approved by the Ethics Committee of Management and
      Science University (MSU). Once the participant agreed to be interviewed, date,
      time and place of the interviews were determined. Consent form was obtained from 
      participants before the interview began. Participants were briefed about the
      study and its purpose, and after asking their permission, their replies were
      recorded. The data was organized into themes and analyzed manually. RESULTS:
      Twenty-five Malaysian traditional healers participated in this qualitative study.
      The age of participants ranged between 26 to 78 years old. The majority were in
      the age group of 31-60 years old, male, Chinese, degree holders with a monthly
      income ranging from 1,000-5,000 Ringgit Malaysia (RM) and were married (56%, 80%,
      48%, 52%, 68%, 84% respectively). The majority defined cancer as having high
      cholesterol or abscess accumulation. A few of them defined cancer as a type of
      cell growth. The majority mentioned that food and unhealthy lifestyles are the
      primary causes of cancer. Surprisingly some of them mentioned that cancer is
      caused by interference by ghosts. Regarding the diagnosis of cancer, the majority
      mentioned that they refer their patients to modern physicians' medical report
      when it comes to diagnosing or treating patients with cancer. The most common
      cancers that many patients came to seek treatment were breast cancers, followed
      by colon cancers, liver and lung cancers. CONCLUSION: Despite good knowledge
      about the causes of cancer among traditional healers, misconceptions still exist.
      Insufficient knowledge about the definition of cancer was noted among the
      traditional healers. This urges immediate action by the Ministry of Health of
      Malaysia to set up a strict regulation and regular monitoring of the traditional 
      healers nationally. Traditional and Complementary Medicine may be integrated into
      the healthcare system and need to have sustained cooperation for the benefit of
      patients since about 80% of patients use traditional medicines.
FAU - Al-Naggar, Redhwan A
AU  - Al-Naggar RA
AD  - Community Medicine Department, International Medical School, Management and
      Science University, Malaysia. radhwan888@yahoo.com
FAU - Bobryshev, Yuri V
AU  - Bobryshev YV
FAU - Abdulghani, Mahfoudh Al-Musali Mohammed
AU  - Abdulghani MA
FAU - Rammohan, Subramanian
AU  - Rammohan S
FAU - Al-Jashamy, Karim
AU  - Al-Jashamy K
LA  - eng
PT  - Journal Article
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
SB  - IM
MH  - Adult
MH  - *Complementary Therapies
MH  - Female
MH  - *Health Behavior
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Malaysia/epidemiology
MH  - Male
MH  - *Medicine, Traditional
MH  - Middle Aged
MH  - Neoplasms/diagnosis/epidemiology/*prevention & control
MH  - Perception
MH  - Prognosis
MH  - Qualitative Research
MH  - Surveys and Questionnaires
EDAT- 2012/10/27 06:00
MHDA- 2013/04/20 06:00
CRDT- 2012/10/27 06:00
PHST- 2012/10/27 06:00 [entrez]
PHST- 2012/10/27 06:00 [pubmed]
PHST- 2013/04/20 06:00 [medline]
AID - 10.7314/apjcp.2012.13.8.3841 [doi]
PST - ppublish
SO  - Asian Pac J Cancer Prev. 2012;13(8):3841-50. doi: 10.7314/apjcp.2012.13.8.3841.


PMID- 23098339
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121123
LR  - 20211021
IS  - 1754-9493 (Electronic)
IS  - 1754-9493 (Linking)
VI  - 6
IP  - 1
DP  - 2012 Oct 25
TI  - Reconstruction of displaced acromio-clavicular joint dislocations using a triple 
      suture-cerclage: description of a safe and efficient surgical technique.
PG  - 25
LID - 10.1186/1754-9493-6-25 [doi]
AB  - UNLABELLED: PURPOSE: In this retrospective study we investigated the clinical and
      radiological outcome after operative treatment of acute Rockwood III-V injuries
      of the AC-joint using two acromioclavicular (AC) cerclages and one
      coracoclavicular (CC) cerclage with resorbable sutures. METHODS: Between 2007 and
      2009 a total of 39 patients fit the inclusion criteria after operative treatment 
      of acute AC joint dislocation. All patients underwent open reduction and anatomic
      reconstruction of the AC and CC-ligaments using PDS(R) sutures (Polydioxane,
      Ethicon, Norderstedt, Germany). Thirty-three patients could be investigated at a 
      mean follow up of 32+/-9 months (range 24-56 months). RESULTS: The mean Constant 
      score was 94.3+/-7.1 (range 73-100) with an age and gender correlated score of
      104.2%+/-6.9 (88-123%). The DASH score (mean 3.46+/-6.6 points), the ASES score
      (94.6+/-9.7points) and the Visual Analogue Scale (mean 0.5+/-0,6) revealed a good
      to excellent clinical outcome. The difference in the coracoclavicular distance
      compared to the contralateral side was <5 mm for 28 patients, between 5-10 mm for
      4 patients, and more than 10 mm for another patient. In the axial view, the
      anterior border of the clavicle was within 1 cm (ventral-dorsal direction) of the
      anterior rim of the acromion in 28 patients (85%). Re-dislocations occured in
      three patients (9%). CONCLUSION: Open AC joint reconstruction using AC and CC PDS
      cerclages provides good to excellent clinical results in the majority of cases.
      However, radiographically, the CC distance increased significantly at final
      follow up, but neither the amount of re-dislocation nor calcifications of the CC 
      ligaments or osteoarthritis of the AC joint had significant influence on the
      outcome. LEVEL OF EVIDENCE: Case series, Level IV.
FAU - Sandmann, Gunther H
AU  - Sandmann GH
AD  - Department of Traumatology, Klinikum rechts der Isar, Technical University
      Munich, Ismaninger Str. 22, Munich D- 81675, Germany.
FAU - Martetschlager, Frank
AU  - Martetschlager F
AD  - Department of Traumatology, Klinikum rechts der Isar, Technical University
      Munich, Ismaninger Str. 22, Munich D- 81675, Germany.
FAU - Mey, Lisa
AU  - Mey L
AD  - Department of Traumatology, Klinikum rechts der Isar, Technical University
      Munich, Ismaninger Str. 22, Munich D- 81675, Germany.
FAU - Kraus, Tobias M
AU  - Kraus TM
AD  - Berufsgenossenschaftliche Unfallklinik Tuebingen, Schnarrenbergstr. 9, Tuebingen 
      D- 72076, Germany.
FAU - Buchholz, Arne
AU  - Buchholz A
AD  - Department of Traumatology, Klinikum rechts der Isar, Technical University
      Munich, Ismaninger Str. 22, Munich D- 81675, Germany.
FAU - Ahrens, Philipp
AU  - Ahrens P
AD  - Department of Traumatology, Klinikum rechts der Isar, Technical University
      Munich, Ismaninger Str. 22, Munich D- 81675, Germany.
FAU - Stockle, Ulrich
AU  - Stockle U
AD  - Berufsgenossenschaftliche Unfallklinik Tuebingen, Schnarrenbergstr. 9, Tuebingen 
      D- 72076, Germany.
FAU - Freude, Thomas
AU  - Freude T
AD  - Berufsgenossenschaftliche Unfallklinik Tuebingen, Schnarrenbergstr. 9, Tuebingen 
      D- 72076, Germany.
FAU - Siebenlist, Sebastian
AU  - Siebenlist S
AD  - Department of Traumatology, Klinikum rechts der Isar, Technical University
      Munich, Ismaninger Str. 22, Munich D- 81675, Germany.
LA  - eng
PT  - Journal Article
DEP - 20121025
PL  - England
TA  - Patient Saf Surg
JT  - Patient safety in surgery
JID - 101319176
PMC - PMC3503776
EDAT- 2012/10/27 06:00
MHDA- 2012/10/27 06:01
CRDT- 2012/10/27 06:00
PHST- 2012/08/02 00:00 [received]
PHST- 2012/10/19 00:00 [accepted]
PHST- 2012/10/27 06:00 [entrez]
PHST- 2012/10/27 06:00 [pubmed]
PHST- 2012/10/27 06:01 [medline]
AID - 1754-9493-6-25 [pii]
AID - 10.1186/1754-9493-6-25 [doi]
PST - epublish
SO  - Patient Saf Surg. 2012 Oct 25;6(1):25. doi: 10.1186/1754-9493-6-25.


PMID- 23098130
OWN - NLM
STAT- MEDLINE
DCOM- 20130325
LR  - 20211021
IS  - 1471-230X (Electronic)
IS  - 1471-230X (Linking)
VI  - 12
DP  - 2012 Oct 25
TI  - The value of pancreatic stone protein in predicting acute appendicitis in
      patients presenting at the emergency department with abdominal pain.
PG  - 154
LID - 10.1186/1471-230X-12-154 [doi]
AB  - BACKGROUND: Pancreatic Stone Protein (PSP) is a protein naturally produced mainly
      in the pancreas and the gut. There is evidence from experimental and clinical
      trials that blood PSP levels rise in the presence of inflammation or infection.
      However, it is not known whether PSP is superior to other established blood tests
      (e.g. White Blood Count, Neutrophils or C - reactive protein) in predicting
      appendicitis in patients presenting with abdominal pain and a clinical suspicion 
      of appendicitis at the emergency room. METHODS/DESIGN: The PSP Appendix Trial is 
      a prospective, multi-center, cohort study to assess the value of PSP in the
      diagnostic workup of acute appendicitis. 245 patients will be prospectively
      recruited. Interim analysis will be performed once 123 patients are recruited.
      The primary endpoint of the study concerns the diagnostic accuracy of PSP in
      predicting acute appendicitis and therefore the evidence of appendicitis on the
      histopathological specimen after appendectomy. DISCUSSION: The PSP Appendix Trial
      is a prospective, multi-center, cohort study to assess the value of PSP in the
      diagnostic workup of acute appendicitis. TRIAL REGISTRATION: ClinicalTrials.gov: 
      NCT01610193; Institution Ethical Board Approval ID: KEKZH- Nr. 2011-0501.
FAU - Tschuor, Christoph
AU  - Tschuor C
AD  - Department of Surgery, University Hospital Zurich, Zurich, Switzerland.
      christoph.tschuor@usz.ch
FAU - Raptis, Dimitri Aristotle
AU  - Raptis DA
FAU - Limani, Perparim
AU  - Limani P
FAU - Bachler, Thomas
AU  - Bachler T
FAU - Oberkofler, Christian Eugen
AU  - Oberkofler CE
FAU - Breitenstein, Stefan
AU  - Breitenstein S
FAU - Graf, Rolf
AU  - Graf R
LA  - eng
SI  - ClinicalTrials.gov/NCT01610193
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20121025
PL  - England
TA  - BMC Gastroenterol
JT  - BMC gastroenterology
JID - 100968547
RN  - 0 (Lithostathine)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Abdominal Pain/diagnosis
MH  - Appendicitis/*diagnosis
MH  - C-Reactive Protein/analysis
MH  - Clinical Protocols
MH  - *Emergency Service, Hospital
MH  - Humans
MH  - Leukocyte Count
MH  - Lithostathine/*blood
PMC - PMC3503734
EDAT- 2012/10/27 06:00
MHDA- 2013/03/26 06:00
CRDT- 2012/10/27 06:00
PHST- 2012/09/24 00:00 [received]
PHST- 2012/10/12 00:00 [accepted]
PHST- 2012/10/27 06:00 [entrez]
PHST- 2012/10/27 06:00 [pubmed]
PHST- 2013/03/26 06:00 [medline]
AID - 1471-230X-12-154 [pii]
AID - 10.1186/1471-230X-12-154 [doi]
PST - epublish
SO  - BMC Gastroenterol. 2012 Oct 25;12:154. doi: 10.1186/1471-230X-12-154.


PMID- 23097855
OWN - NLM
STAT- MEDLINE
DCOM- 20121120
LR  - 20121026
IS  - 0019-6568 (Print)
IS  - 0019-6568 (Linking)
VI  - 91
IP  - 3
DP  - 2012 Fall
TI  - Dental ethics: an obituary.
PG  - 18-22
FAU - Jones, Richard E
AU  - Jones RE
AD  - Indiana Dental Association, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Indiana Dent Assoc
JT  - Journal (Indiana Dental Association)
JID - 8502537
MH  - *Commerce
MH  - *Ethics, Dental
MH  - Humans
MH  - Indiana
MH  - Marketing of Health Services/economics
MH  - Mentors
MH  - Practice Management, Dental/*economics
MH  - Professional Autonomy
MH  - Professional Role
MH  - Societies, Dental
EDAT- 2012/10/27 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/10/27 06:00
PHST- 2012/10/27 06:00 [entrez]
PHST- 2012/10/27 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
PST - ppublish
SO  - J Indiana Dent Assoc. 2012 Fall;91(3):18-22.


PMID- 23097640
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121026
LR  - 20211021
IS  - 1662-5161 (Electronic)
IS  - 1662-5161 (Linking)
VI  - 6
DP  - 2012
TI  - Neuroimaging in mental health care: voices in translation.
PG  - 293
LID - 10.3389/fnhum.2012.00293 [doi]
AB  - Images of brain function, popularly called "neuroimages," have become a mainstay 
      of contemporary communication about neuroscience and mental health. Paralleling
      media coverage of neuroimaging research and the high visibility of clinics
      selling scans is pressure from sponsors to move basic research about brain
      function along the translational pathway. Indeed, neuroimaging may offer benefits
      to mental health care: early or tailored intervention, opportunities for
      education and planning, and access to resources afforded by objectification of
      disorder. However, risks of premature technology transfer, such as
      misinterpretation, misrepresentation, and increased stigmatization, could
      compromise patient care. The insights of stakeholder groups about neuroimaging
      for mental health care are a largely untapped resource of information and
      guidance for translational efforts. We argue that the insights of key
      stakeholders-including researchers, healthcare providers, patients, and
      families-have an essential role to play upstream in professional, critical, and
      ethical discourse surrounding neuroimaging in mental health. Here we integrate
      previously orthogonal lines of inquiry involving stakeholder research to describe
      the translational landscape as well as challenges on its horizon.
FAU - Borgelt, Emily L
AU  - Borgelt EL
AD  - National Core for Neuroethics, Department of Neurology, University of British
      Columbia Vancouver, BC, Canada.
FAU - Buchman, Daniel Z
AU  - Buchman DZ
FAU - Illes, Judy
AU  - Illes J
LA  - eng
GR  - R01 MH084282/MH/NIMH NIH HHS/United States
PT  - Journal Article
DEP - 20121022
PL  - Switzerland
TA  - Front Hum Neurosci
JT  - Frontiers in human neuroscience
JID - 101477954
PMC - PMC3477886
OTO - NOTNLM
OT  - bioethics
OT  - neuroethics
OT  - neuroimaging
OT  - psychiatry
OT  - qualitative research
EDAT- 2012/10/26 06:00
MHDA- 2012/10/26 06:01
CRDT- 2012/10/26 06:00
PHST- 2012/07/12 00:00 [received]
PHST- 2012/10/03 00:00 [accepted]
PHST- 2012/10/26 06:00 [entrez]
PHST- 2012/10/26 06:00 [pubmed]
PHST- 2012/10/26 06:01 [medline]
AID - 10.3389/fnhum.2012.00293 [doi]
PST - epublish
SO  - Front Hum Neurosci. 2012 Oct 22;6:293. doi: 10.3389/fnhum.2012.00293. eCollection
      2012.


PMID- 23097599
OWN - NLM
STAT- MEDLINE
DCOM- 20130116
LR  - 20211203
IS  - 1110-7251 (Electronic)
IS  - 1110-7243 (Linking)
VI  - 2012
DP  - 2012
TI  - Lim mineralization protein 3 induces the osteogenic differentiation of human
      amniotic fluid stromal cells through Kruppel-like factor-4 downregulation and
      further bone-specific gene expression.
PG  - 813894
LID - 10.1155/2012/813894 [doi]
AB  - Multipotent mesenchymal stem cells with extensive self-renewal properties can be 
      easily isolated and rapidly expanded in culture from small volumes of amniotic
      fluid. These cells, namely, amniotic fluid-stromal cells (AFSCs), can be regarded
      as an attractive source for tissue engineering purposes, being phenotypically and
      genetically stable, plus overcoming all the safety and ethical issues related to 
      the use of embryonic/fetal cells. LMP3 is a novel osteoinductive molecule acting 
      upstream to the main osteogenic pathways. This study is aimed at delineating the 
      basic molecular events underlying LMP3-induced osteogenesis, using AFSCs as a
      cellular model to focus on the molecular features underlying the
      multipotency/differentiation switch. For this purpose, AFSCs were isolated and
      characterized in vitro and transfected with a defective adenoviral vector
      expressing the human LMP3. LMP3 induced the successful osteogenic differentiation
      of AFSC by inducing the expression of osteogenic markers and osteospecific
      transcription factors. Moreover, LMP3 induced an early repression of the
      Kruppel-like factor-4, implicated in MSC stemness maintenance. KLF4 repression
      was released upon LMP3 silencing, indicating that this event could be reasonably 
      considered among the basic molecular events that govern the
      proliferation/differentiation switch during LMP3-induced osteogenic
      differentiation of AFSC.
FAU - Barba, Marta
AU  - Barba M
AD  - Institute of Anatomy and Cell Biology, Universita Cattolica del Sacro Cuore, Lgo 
      F Vito 1, 00168 Rome, Italy.
FAU - Pirozzi, Filomena
AU  - Pirozzi F
FAU - Saulnier, Nathalie
AU  - Saulnier N
FAU - Vitali, Tiziana
AU  - Vitali T
FAU - Natale, Maria Teresa
AU  - Natale MT
FAU - Logroscino, Giandomenico
AU  - Logroscino G
FAU - Robbins, Paul D
AU  - Robbins PD
FAU - Gambotto, Andrea
AU  - Gambotto A
FAU - Neri, Giovanni
AU  - Neri G
FAU - Michetti, Fabrizio
AU  - Michetti F
FAU - Pola, Enrico
AU  - Pola E
FAU - Lattanzi, Wanda
AU  - Lattanzi W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121002
PL  - United States
TA  - J Biomed Biotechnol
JT  - Journal of biomedicine & biotechnology
JID - 101135740
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (KLF4 protein, human)
RN  - 0 (Kruppel-Like Factor 4)
RN  - 0 (Kruppel-Like Transcription Factors)
RN  - 0 (LIM Domain Proteins)
RN  - 0 (LIM mineralization protein-3, human)
SB  - IM
MH  - Amniotic Fluid/*cytology
MH  - Cell Differentiation
MH  - Cells, Cultured
MH  - Down-Regulation
MH  - Female
MH  - Gene Expression Regulation, Developmental/physiology
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins/*metabolism
MH  - Kruppel-Like Factor 4
MH  - Kruppel-Like Transcription Factors/*metabolism
MH  - LIM Domain Proteins/*metabolism
MH  - Osteoblasts/*cytology/*metabolism
MH  - Osteogenesis/physiology
MH  - Stromal Cells/*cytology/*metabolism
PMC - PMC3471036
EDAT- 2012/10/26 06:00
MHDA- 2013/01/17 06:00
CRDT- 2012/10/26 06:00
PHST- 2012/01/23 00:00 [received]
PHST- 2012/04/19 00:00 [revised]
PHST- 2012/04/30 00:00 [accepted]
PHST- 2012/10/26 06:00 [entrez]
PHST- 2012/10/26 06:00 [pubmed]
PHST- 2013/01/17 06:00 [medline]
AID - 10.1155/2012/813894 [doi]
PST - ppublish
SO  - J Biomed Biotechnol. 2012;2012:813894. doi: 10.1155/2012/813894. Epub 2012 Oct 2.


PMID- 23096776
OWN - NLM
STAT- MEDLINE
DCOM- 20140122
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 3
DP  - 2013 Sep
TI  - Midstream modulation in biotechnology industry: redefining what is 'part of the
      job' of researchers in industry.
PG  - 1141-64
LID - 10.1007/s11948-012-9411-6 [doi]
AB  - In response to an increasing amount of policy papers stressing the need for
      integrating social and ethical aspects in Research and Development (R&D)
      practices, science studies scholars have conducted integrative research and
      experiments with science and innovation actors. One widely employed integration
      method is Midstream Modulation (MM), in which an 'embedded humanist' interacts in
      regular meetings with researchers to engage them with the social and ethical
      aspects of their work. While the possibility of using MM to enhance critical
      reflection has been demonstrated in academic settings, few attempts have been
      made to examine its appropriateness in industry. This paper describes the
      outcomes of a case study aiming to find out firstly whether MM can effectively be
      deployed to encourage and facilitate researchers to actively include social and
      ethical aspects in their daily R&D practice, and secondly to what extent the
      integration activities could form an integral part of the engaged industrial
      researchers' professional activities. Our data show that after MM, researchers
      display increased reflexive awareness on the social and ethical aspects of their 
      work and acknowledge the relevance and utility of such aspects on their daily
      practice. Also, all participants considered actively reflecting on social and
      ethical aspects to be part of their work. Future research on the role of MM in
      industrial settings could focus on how to embed social and ethical integration as
      a regular part of innovation practice. We suggest that one possibility would be
      through aligning social and ethical aspects with innovation Key Performance
      Indicators.
FAU - Flipse, Steven M
AU  - Flipse SM
AD  - Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628
      BC, Delft, The Netherlands. s.m.flipse@tudelft.nl
FAU - van der Sanden, Maarten C A
AU  - van der Sanden MC
FAU - Osseweijer, Patricia
AU  - Osseweijer P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121025
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Awareness
MH  - Biotechnology/*ethics
MH  - *Ethics, Research
MH  - Humanities
MH  - Humans
MH  - Research Design
MH  - Research Personnel
MH  - Science/*ethics
MH  - *Social Responsibility
MH  - Work
EDAT- 2012/10/26 06:00
MHDA- 2014/01/23 06:00
CRDT- 2012/10/26 06:00
PHST- 2012/04/16 00:00 [received]
PHST- 2012/10/08 00:00 [accepted]
PHST- 2012/10/26 06:00 [entrez]
PHST- 2012/10/26 06:00 [pubmed]
PHST- 2014/01/23 06:00 [medline]
AID - 10.1007/s11948-012-9411-6 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Sep;19(3):1141-64. doi: 10.1007/s11948-012-9411-6. Epub 2012
      Oct 25.


PMID- 23096497
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130108
LR  - 20211021
IS  - 1868-310X (Print)
IS  - 1868-310X (Linking)
VI  - 4
IP  - 1
DP  - 2013 Jan
TI  - Prenatal diagnosis and termination of pregnancy: perspectives of South African
      parents of children with Down syndrome.
PG  - 87-97
LID - 10.1007/s12687-012-0122-0 [doi]
AB  - This study aims to evaluate the attitudes of a group of South African parents
      with a preschool child with Down syndrome (DS) towards prenatal diagnosis (PND)
      and termination of a Down syndrome-affected pregnancy (TAP). This study employs a
      qualitative phenomenological approach with the use of semi-structured interviews.
      Twelve participants were recruited from two state sector hospitals in Cape Town, 
      South Africa. Thematic analysis was used to interpret the data. The participants 
      had a positive attitude towards PND and felt that it was every parent's right to 
      have the option. They considered a benefit of PND the fact that it allowed
      parents time to prepare for the arrival of a baby with DS. The induced
      miscarriage risk associated with invasive prenatal testing procedures caused
      major negative feelings. They were totally opposed to the termination of a Down
      syndrome-affected pregnancy due to their personal experience, moral, ethical or
      religious convictions. South African parents of preschool children with Down
      syndrome are comfortable with PND for Down syndrome; however, they do not support
      TAP. These findings will provide health care providers with further insight into 
      the motivations behind the decisions their patients make.
FAU - Scott, Chantelle Jennifer
AU  - Scott CJ
AD  - Division of Human Genetics, Department of Clinical Laboratory Sciences, Faculty
      of Health Sciences, University of Cape Town, Anzio Road-7925, Observatory, Cape
      Town, South Africa.
FAU - Futter, Merle
AU  - Futter M
FAU - Wonkam, Ambroise
AU  - Wonkam A
LA  - eng
PT  - Journal Article
DEP - 20121025
PL  - Germany
TA  - J Community Genet
JT  - Journal of community genetics
JID - 101551501
PMC - PMC3537964
EDAT- 2012/10/26 06:00
MHDA- 2012/10/26 06:01
CRDT- 2012/10/26 06:00
PHST- 2012/01/12 00:00 [received]
PHST- 2012/10/03 00:00 [accepted]
PHST- 2012/10/26 06:00 [entrez]
PHST- 2012/10/26 06:00 [pubmed]
PHST- 2012/10/26 06:01 [medline]
AID - 10.1007/s12687-012-0122-0 [doi]
PST - ppublish
SO  - J Community Genet. 2013 Jan;4(1):87-97. doi: 10.1007/s12687-012-0122-0. Epub 2012
      Oct 25.


PMID- 23096112
OWN - NLM
STAT- MEDLINE
DCOM- 20130529
LR  - 20121122
IS  - 1744-5019 (Electronic)
IS  - 0360-5310 (Linking)
VI  - 37
IP  - 5
DP  - 2012 Oct
TI  - Consent and the use of the bodies of the dead.
PG  - 445-63
LID - 10.1093/jmp/jhs041 [doi]
AB  - Gametes, tissue, and organs can be taken from the dying or dead for reproduction,
      transplantation, and research. Whole bodies as well as parts can be used for
      teaching anatomy. While these uses are diverse, they have an ethical
      consideration in common: the claims of the people whose bodies are used. Is some 
      use permissible only when people have consented to the use, actually wanted the
      use, would have wanted the use, not opposed the use, or what? The aim of this
      article is to make progress in answering these questions. Initially I assume
      knowledge of people's desires in order to test whether consent is directly
      required by their rights without worrying about mistaken uses against their
      wishes. I claim consent is not directly required by people's rights. If we know
      people wanted or would want a use, their rights permit the use, but if we know
      they wanted or would want not to be used, their rights do not permit the use. The
      knowledge assumption is then dropped and the question becomes how to decide what 
      to do when the wishes of rightholders are not known. I suggest working out what
      to do when wishes are known and then adjusting, on the basis of whatever evidence
      there is, for probability and strength of desire. There are other considerations 
      too, for instance about default rules. The key general comment here is that, in
      setting rules, the costs to rightholders in not getting what they want needs to
      be taken into account. The final section tries to show that, in setting these
      rules, mistaken uses are not to be taken as worse than mistaken failure to use.
FAU - Wilkinson, T M
AU  - Wilkinson TM
AD  - University of Auckland, Auckland, New Zealand. m.wilkinson@auckland.ac.nz
LA  - eng
PT  - Journal Article
DEP - 20121024
PL  - United States
TA  - J Med Philos
JT  - The Journal of medicine and philosophy
JID - 7610512
SB  - IM
MH  - *Attitude to Death
MH  - *Bioethics
MH  - *Cadaver
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Intention
MH  - Morals
MH  - *Personal Autonomy
MH  - Tissue and Organ Procurement/*ethics
EDAT- 2012/10/26 06:00
MHDA- 2013/05/31 06:00
CRDT- 2012/10/26 06:00
PHST- 2012/10/26 06:00 [entrez]
PHST- 2012/10/26 06:00 [pubmed]
PHST- 2013/05/31 06:00 [medline]
AID - jhs041 [pii]
AID - 10.1093/jmp/jhs041 [doi]
PST - ppublish
SO  - J Med Philos. 2012 Oct;37(5):445-63. doi: 10.1093/jmp/jhs041. Epub 2012 Oct 24.


PMID- 23095928
OWN - NLM
STAT- MEDLINE
DCOM- 20130211
LR  - 20211021
IS  - 1938-808X (Electronic)
IS  - 1040-2446 (Linking)
VI  - 87
IP  - 12
DP  - 2012 Dec
TI  - Are central institutional review boards the solution? The National Heart, Lung,
      and Blood Institute Working Group's report on optimizing the IRB process.
PG  - 1710-4
LID - 10.1097/ACM.0b013e3182720859 [doi]
AB  - The National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes 
      of Health convened a working group in June 2011 to examine alternative
      institutional review board (IRB) models. The working group was held in response
      to proposed changes in the regulations for government-supported research and the 
      proliferation of multicenter clinical trials where multiple individual reviews
      may be inefficient. Group members included experts in heart, lung, and blood
      research, research oversight, bioethics, health economics, regulations, and
      information technology (IT). The group discussed alternative IRB models, ethical 
      concerns, metrics for evaluating IRBs, IT needs, and economic considerations.
      Participants noted research gaps in IRB best practices and in metrics. The group 
      arrived at recommendations for process changes, such as defining specific IRB
      performance requirements in funding announcements, requiring funded researchers
      to use more efficient alternative IRB models, and developing IT systems to
      facilitate information sharing and collaboration among IRBs. Despite the success 
      of the National Cancer Institute's central IRB (CIRB), the working group,
      concerned about the creation costs and unknown cost-efficiency of a new CIRB, and
      about the risk of shifting the burden of dealing with multiple IRBs from sponsors
      to research institutions, did not recommend the creation of an NHLBI-funded CIRB.
FAU - Mascette, Alice M
AU  - Mascette AM
AD  - Office of Special Projects, Division of Cardiovascular Sciences, National Heart, 
      Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
      20892-7940, USA. Alice.Mascette@NIH.gov
FAU - Bernard, Gordon R
AU  - Bernard GR
FAU - Dimichele, Donna
AU  - Dimichele D
FAU - Goldner, Jesse A
AU  - Goldner JA
FAU - Harrington, Robert
AU  - Harrington R
FAU - Harris, Paul A
AU  - Harris PA
FAU - Leeds, Hilary S
AU  - Leeds HS
FAU - Pearson, Thomas A
AU  - Pearson TA
FAU - Ramsey, Bonnie
AU  - Ramsey B
FAU - Wagner, Todd H
AU  - Wagner TH
LA  - eng
GR  - UL1 TR000423/TR/NCATS NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Acad Med
JT  - Academic medicine : journal of the Association of American Medical Colleges
JID - 8904605
SB  - IM
MH  - Biomedical Research/standards
MH  - Conflict of Interest
MH  - Efficiency, Organizational
MH  - Ethics Committees, Research/economics/*organization & administration/standards
MH  - Financing, Government
MH  - Humans
MH  - *Models, Organizational
MH  - Organizational Policy
MH  - Research Support as Topic
MH  - United States
PMC - PMC4267852
MID - NIHMS506712
EDAT- 2012/10/26 06:00
MHDA- 2013/02/12 06:00
CRDT- 2012/10/26 06:00
PHST- 2012/10/26 06:00 [entrez]
PHST- 2012/10/26 06:00 [pubmed]
PHST- 2013/02/12 06:00 [medline]
AID - 10.1097/ACM.0b013e3182720859 [doi]
PST - ppublish
SO  - Acad Med. 2012 Dec;87(12):1710-4. doi: 10.1097/ACM.0b013e3182720859.


PMID- 23095128
OWN - NLM
STAT- MEDLINE
DCOM- 20140303
LR  - 20151119
IS  - 2168-1813 (Electronic)
IS  - 2168-1805 (Linking)
VI  - 47
IP  - 3
DP  - 2013 Jun
TI  - Use of three types of synthetic mesh material in sling surgery: a prospective
      randomized clinical trial evaluating effectiveness and complications.
PG  - 217-24
LID - 10.3109/00365599.2012.733962 [doi]
AB  - OBJECTIVE: The aim of this study was to determine the surgical success and
      complication rates of mixed type of mesh materials compared with Prolene mesh in 
      sling surgery over a 4-year follow-up period. MATERIAL AND METHODS: Between 2005 
      and 2007, broad-based double-forced sling operations were performed in 144 women 
      with stress incontinence using three different types of mesh material. Group I
      consisted of 48 patients in whom Vypro(R) mesh (Ethicon, USA) was used; group II 
      of 48 patients in whom Ultrapro(R) mesh (Ethicon) and group III of 48 patients in
      whom Prolene(R) light mesh (Ethicon) was used. The patients' data and the success
      of the operation were evaluated based on the 24 h pad test, International
      Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF) scoring and
      Korman questionnaire analysis. RESULTS: The ICIQ-SF score, the number of pads
      used and the results of 24 h pad test were statistically lower in group II at
      postoperative month 48 (p < 0.05). The rate of postoperative complications was
      lower in Group II than in the other groups (p < 0.05). The continence rates of
      groups I, II and III were 84.7%, 91.6% and 85.1%, respectively, in the 48th
      postoperative month. CONCLUSIONS: Ultrapro mesh can be used in sling surgery
      owing to its higher success rates, and lower vaginal and urethral extrusion and
      de novo urgency rates, which have also been shown in clinical studies.
FAU - Okulu, Emrah
AU  - Okulu E
AD  - The Urology Clinics of Ataturk Training and Research Hospital, Ankara, Turkey.
      eokulu@yahoo.com
FAU - Kayigil, Onder
AU  - Kayigil O
FAU - Aldemir, Mustafa
AU  - Aldemir M
FAU - Onen, Efe
AU  - Onen E
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20121025
PL  - England
TA  - Scand J Urol
JT  - Scandinavian journal of urology
JID - 101587186
RN  - 0 (Polypropylenes)
RN  - 0 (VyproII)
RN  - 34346-01-5 (Polyglactin 910)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Follow-Up Studies
MH  - Gynecologic Surgical Procedures/*methods
MH  - Humans
MH  - Middle Aged
MH  - Polyglactin 910
MH  - Polypropylenes
MH  - Postoperative Complications/*epidemiology
MH  - Prevalence
MH  - Prospective Studies
MH  - Suburethral Slings/*classification
MH  - Surgical Mesh/*classification
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
MH  - Urinary Incontinence, Stress/epidemiology/*surgery
EDAT- 2012/10/26 06:00
MHDA- 2014/03/04 06:00
CRDT- 2012/10/26 06:00
PHST- 2012/10/26 06:00 [entrez]
PHST- 2012/10/26 06:00 [pubmed]
PHST- 2014/03/04 06:00 [medline]
AID - 10.3109/00365599.2012.733962 [doi]
PST - ppublish
SO  - Scand J Urol. 2013 Jun;47(3):217-24. doi: 10.3109/00365599.2012.733962. Epub 2012
      Oct 25.


PMID- 23095097
OWN - NLM
STAT- MEDLINE
DCOM- 20130705
LR  - 20211021
IS  - 1557-8070 (Electronic)
IS  - 1557-8070 (Linking)
VI  - 12
IP  - 11
DP  - 2012 Nov
TI  - Ethical considerations for planetary protection in space exploration: a workshop.
PG  - 1017-23
LID - 10.1089/ast.2012.0891 [doi]
AB  - With the recognition of an increasing potential for discovery of extraterrestrial
      life, a diverse set of researchers have noted a need to examine the foundational 
      ethical principles that should frame our collective space activities as we
      explore outer space. A COSPAR Workshop on Ethical Considerations for Planetary
      Protection in Space Exploration was convened at Princeton University on June
      8-10, 2010, to examine whether planetary protection measures and practices should
      be extended to protect planetary environments within an ethical framework that
      goes beyond "science protection" per se. The workshop had been in development
      prior to a 2006 NRC report on preventing the forward contamination of Mars,
      although it responded directly to one of the recommendations of that report and
      to several peer-reviewed papers as well. The workshop focused on the implications
      and responsibilities engendered when exploring outer space while avoiding harmful
      impacts on planetary bodies. Over 3 days, workshop participants developed a set
      of recommendations addressing the need for a revised policy framework to address 
      "harmful contamination" beyond biological contamination, noting that it is
      important to maintain the current COSPAR planetary protection policy for
      scientific exploration and activities. The attendees agreed that there is need
      for further study of the ethical considerations used on Earth and the examination
      of management options and governmental mechanisms useful for establishing an
      environmental stewardship framework that incorporates both scientific input and
      enforcement. Scientists need to undertake public dialogue to communicate widely
      about these future policy deliberations and to ensure public involvement in
      decision making. A number of incremental steps have been taken since the workshop
      to implement some of these recommendations.
FAU - Rummel, J D
AU  - Rummel JD
AD  - East Carolina University, Greenville, North Carolina, USA.
FAU - Race, M S
AU  - Race MS
FAU - Horneck, G
AU  - Horneck G
CN  - Princeton Workshop Participants
LA  - eng
PT  - Consensus Development Conference
PT  - Journal Article
DEP - 20121024
PL  - United States
TA  - Astrobiology
JT  - Astrobiology
JID - 101088083
SB  - IM
EIN - Astrobiology. 2012 Dec;12(12):1165
MH  - Exobiology
MH  - Humans
MH  - Planets
MH  - Public Policy
MH  - Space Flight/*ethics/standards
MH  - United States
MH  - United States National Aeronautics and Space Administration
PMC - PMC3698687
IR  - Arnould J
FIR - Arnould, Jacques
IR  - Baker A
FIR - Baker, Amy
IR  - Billings L
FIR - Billings, Linda
IR  - Boston P
FIR - Boston, Penny
IR  - Chyba C
FIR - Chyba, Christopher
IR  - Cleland C
FIR - Cleland, Carol
IR  - Clifford S
FIR - Clifford, Stephen
IR  - Conley C
FIR - Conley, Cassie
IR  - Ehrenfreund P
FIR - Ehrenfreund, Pascale
IR  - Foote E
FIR - Foote, Emily
IR  - Gabrynowicz J
FIR - Gabrynowicz, Joanne
IR  - Horneck G
FIR - Horneck, Gerda
IR  - Kerrest A
FIR - Kerrest, Armel
IR  - Kminek G
FIR - Kminek, Gerhard
IR  - Lupisella M
FIR - Lupisella, Mark
IR  - McKay C
FIR - McKay, Christopher
IR  - Onstott TC
FIR - Onstott, T C
IR  - Paige D
FIR - Paige, David
IR  - Peters T
FIR - Peters, Ted
IR  - Priest S
FIR - Priest, Susanna
IR  - Race M
FIR - Race, Margaret
IR  - Randolph R
FIR - Randolph, Richard
IR  - Rettberg P
FIR - Rettberg, Petra
IR  - Rummel J
FIR - Rummel, John
IR  - Stackhouse B
FIR - Stackhouse, Brandon
IR  - Wilson E
FIR - Wilson, Elspeth
IR  - Worms JC
FIR - Worms, Jean-Claude
EDAT- 2012/10/26 06:00
MHDA- 2013/07/06 06:00
CRDT- 2012/10/26 06:00
PHST- 2012/10/26 06:00 [entrez]
PHST- 2012/10/26 06:00 [pubmed]
PHST- 2013/07/06 06:00 [medline]
AID - 10.1089/ast.2012.0891 [doi]
PST - ppublish
SO  - Astrobiology. 2012 Nov;12(11):1017-23. doi: 10.1089/ast.2012.0891. Epub 2012 Oct 
      24.


PMID- 23094965
OWN - NLM
STAT- MEDLINE
DCOM- 20140921
LR  - 20211021
IS  - 1467-9566 (Electronic)
IS  - 0141-9889 (Linking)
VI  - 35
IP  - 6
DP  - 2013 Jul
TI  - Brain talk: power and negotiation in children's discourse about self, brain and
      behaviour.
PG  - 813-27
LID - 10.1111/j.1467-9566.2012.01531.x [doi]
AB  - This article examines children's discourse about self, brain and behaviour,
      focusing on the dynamics of power, knowledge and responsibility articulated by
      children. The empirical data discussed in this article are drawn from the study
      of Voices on Identity, Childhood, Ethics and Stimulants, which included
      interviews with 151 US and UK children, a subset of whom had a diagnosis of
      attention deficit/hyperactivity disorder. Despite their contact with psychiatric 
      explanations and psychotropic drugs for their behaviour, children's discursive
      engagements with the brain show significant evidence of agency and negotiated
      responsibility. These engagements suggest the limitations of current concepts
      that describe a collapse of the self into the brain in an age of neurocentrism.
      Empirical investigation is needed in order to develop agent-centred conceptual
      and theoretical frameworks that describe and evaluate the harms and benefits of
      treating children with psychotropic drugs and other brain-based technologies.
CI  - (c) 2012 The Author. Sociology of Health & Illness (c) 2012 Foundation for the
      Sociology of Health & Illness/John Wiley & Sons Ltd.
FAU - Singh, Ilina
AU  - Singh I
AD  - Department of Social Science, Health and Medicine, King's College, London.
      ilina.singh@kcl.ac.uk
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121025
PL  - England
TA  - Sociol Health Illn
JT  - Sociology of health & illness
JID - 8205036
SB  - IM
MH  - Adolescent
MH  - Attention Deficit Disorder with Hyperactivity/diagnosis/*psychology/therapy
MH  - Brain/*physiology
MH  - Child
MH  - *Child Behavior
MH  - *Decision Making
MH  - Humans
MH  - Male
MH  - Neurosciences
MH  - Power, Psychological
MH  - *Self Psychology
MH  - Social Stigma
MH  - Surveys and Questionnaires
MH  - United Kingdom
MH  - United States
MH  - Voice
PMC - PMC3757316
OTO - NOTNLM
OT  - ADHD
OT  - Ritalin
OT  - brain
OT  - children
OT  - self
EDAT- 2012/10/26 06:00
MHDA- 2014/09/23 06:00
CRDT- 2012/10/26 06:00
PHST- 2012/10/26 06:00 [entrez]
PHST- 2012/10/26 06:00 [pubmed]
PHST- 2014/09/23 06:00 [medline]
AID - 10.1111/j.1467-9566.2012.01531.x [doi]
PST - ppublish
SO  - Sociol Health Illn. 2013 Jul;35(6):813-27. doi: 10.1111/j.1467-9566.2012.01531.x.
      Epub 2012 Oct 25.


PMID- 23094568
OWN - NLM
STAT- MEDLINE
DCOM- 20121106
LR  - 20180324
IS  - 0305-5000 (Print)
IS  - 0305-5000 (Linking)
VI  - 39
IP  - 7
DP  - 2012 Sep
TI  - Ethical marketing in 'aesthetic' ('esthetic') or'cosmetic dentistry'. Part 3.
PG  - 472-4, 476-8, 481-2 passim
AB  - UNLABELLED: This, the third and final article in this series on ethical
      marketing, makes it clear that cosmetic dentistry is not a guaranteed one-way
      ticket to happiness for either patients or dentists, but it can be for lawyers.
      In fact, this area of dentistry is fraught with many dangers for the unwary
      patient and even for the enthusiastic or experienced dentist. In general, it is
      not at all wise to raise patient expectations beyond that which is definitely
      going to be easily achievable in his/her particular case. CLINICAL RELEVANCE: If 
      things go wrong with extensive cosmetic dentistry, or are judged as being
      suboptimal, or unacceptable, by the patient, then that dentist may become liable 
      for all the remakes of that elective cosmetic dentistry for the lifetime of the
      patient, together with all the associated general and specific damages. This is
      because, if the elective cosmetic dentistry had not been done, the patient would 
      not have needed to have the remakes. Informed consent is a major issue with
      cosmetic dentistry, as is avoiding any possible claims for breach of contract,
      which could be verbal, implied or written.
FAU - Kelleher, Martin G D
AU  - Kelleher MG
AD  - King's College Hospital, London SE5 9RS, UK.
FAU - Djemal, Serpil
AU  - Djemal S
FAU - Lewis, Nicholas
AU  - Lewis N
LA  - eng
PT  - Journal Article
PL  - England
TA  - Dent Update
JT  - Dental update
JID - 7805969
CIN - Dent Update. 2012 Oct;39(8):588-9. PMID: 23167210
CIN - Dent Update. 2012 Oct;39(8):589. PMID: 23167211
MH  - *Esthetics, Dental
MH  - Humans
MH  - Informed Consent
MH  - Liability, Legal
MH  - Marketing of Health Services/*ethics
MH  - Patient Satisfaction
MH  - Risk Management
MH  - Specialties, Dental
EDAT- 2012/10/26 06:00
MHDA- 2012/11/07 06:00
CRDT- 2012/10/26 06:00
PHST- 2012/10/26 06:00 [entrez]
PHST- 2012/10/26 06:00 [pubmed]
PHST- 2012/11/07 06:00 [medline]
AID - 10.12968/denu.2012.39.7.472 [doi]
PST - ppublish
SO  - Dent Update. 2012 Sep;39(7):472-4, 476-8, 481-2 passim. doi:
      10.12968/denu.2012.39.7.472.


PMID- 23094441
OWN - NLM
STAT- MEDLINE
DCOM- 20121119
LR  - 20121025
IS  - 0033-2240 (Print)
IS  - 0033-2240 (Linking)
VI  - 69
IP  - 6
DP  - 2012
TI  - [Moral and religious issues in health care].
PG  - 271-4
AB  - The paper summarises the moral and spiritual factors important in care for sick
      people. Medical care is one of the ancient forms of our activity as humans,
      expounding care for other people's well-being. The moral aspect of medical care
      is deeply rooted in constant daily interaction between the patient and the doctor
      aiming at easing symptoms, support, help, prevention and defense. Such
      teleological orientation of medicine is, according to John Paul II, made possible
      not so much by technology but by physician's conscience, wisdom and unlimited
      honesty. This is where ethics is needed to regulate that particular relation.
      This ethics stems from Christian morality, which raises our role as humans to
      that of guardians of dignity of another human being. Man is indeed the measure of
      all things, and this becomes the context for all relations including man's
      relation to God, but also relation of God to man. Thus, human dignity assumes the
      status of unconditional natural rule, inherently forestalling all legal
      arrangements. The morality of health care requires holistic approach, including
      care for body, mind, social interaction and spiritual needs. Only then, as
      explained by dr Ewa Kucharska, is it possible to answer patient's all needs. The 
      moral side of the therapeutic contract bounds the doctor and the patient, alike. 
      From this point of view, it is immoral not to cooperate with physicians in their 
      strife for the preservation of health and life itself. Self negligence or active 
      self harm (drugs, alcohol abuse, HIV/AIDS) are the utmost examples of such
      dishonesty. Finally, the imperative to bring hope and faith to the suffering,
      vests special importance in hospital chaplains, who bring good word, but most
      importantly the sacrament to those in need. The prayer in turn may evoke strong
      hope for cure, capable of supporting both soul and body. The suffering of man
      cannot be understood on rational grounds. It requires acceptance, and, above all,
      it requires faith. And this understanding is reached only by faith and
      participation in Christ's sufferings.
FAU - Necek, Robert
AU  - Necek R
AD  - Adiunkt w Katedrze Teologii Moralnej Ogolnej, Uniwersytet Papieski Jana Pawla II,
      Rzecznik Prasowy Archidiecezji Krakowskiej Konsultor ds. Srodkow Spolecznego
      Przekazu Konferencji Episkopatu Polski. robertus36@wp.pl
LA  - pol
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Moralno-religijne aspekty opieki medycznej.
PL  - Poland
TA  - Przegl Lek
JT  - Przeglad lekarski
JID - 19840720R
SB  - IM
MH  - *Attitude to Health
MH  - Catholicism
MH  - Chaplaincy Service, Hospital
MH  - *Holistic Health
MH  - Humans
MH  - Moral Obligations
MH  - *Physician-Patient Relations
MH  - Poland
MH  - *Religion and Medicine
MH  - Self Concept
MH  - Spirituality
EDAT- 2012/10/26 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/10/26 06:00
PHST- 2012/10/26 06:00 [entrez]
PHST- 2012/10/26 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
PST - ppublish
SO  - Przegl Lek. 2012;69(6):271-4.


PMID- 23094157
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121025
LR  - 20211021
IS  - 2090-2158 (Electronic)
VI  - 2012
DP  - 2012
TI  - Renal function in patients with hypertension associated congestive cardiac
      failure seen in a tertiary hospital.
PG  - 769103
LID - 10.1155/2012/769103 [doi]
AB  - Background. Chronic kidney disease is frequently seen in patients with congestive
      cardiac failure and is an independent risk factor for morbidity and mortality.
      The aim of this study was to determine the prevalence of chronic kidney disease
      in patients with hypertension associated congestive cardiac failure. Method. One 
      hundred and fifty patients with hypertension associated congestive cardiac
      failure were recruited consecutively from the medical outpatient department and
      the medical wards of the Nnamdi Azikiwe University Teaching Hospital Nnewi over a
      one year period, January to December 2010. Patients' biodata and medical history 
      were obtained, detailed physical examination done and each patient had a chest
      X-ray, 12 lead ECG, urinalysis, serum urea and creatinine assay done. Ethical
      clearance was obtained from the Ethical Review Board of our institution and data 
      analysed using SPSS-version 16. Results. There were 86 males and 64 females with 
      mean age 62.7 +/- 12.5 years. The mean blood pressures were systolic 152.8 +/-
      28.5 mmHg and diastolic 94.3 +/- 18 mmHg. 84.7% had blood pressure >/=140/90 mmHg
      on presentation. The mean GFR was 70.1 +/- 31.3 mls/min. 76% of subjects had GFR 
      <90 mls/min and no statistical significant difference between males and females, 
      P = 0.344. The mean serum urea was 7.2 +/- 51 mmol/L while the mean serum
      creatinine was 194 +/- 416.2 mmol/L. Conclusions. This study has demonstrated
      that majority of patients presenting with hypertension associated congestive
      cardiac failure have some degree of chronic kidney disease.
FAU - Osuji, C U
AU  - Osuji CU
AD  - Department of Medicine, Nnamdi Azikiwe University Teaching Hospital, PMB 5025,
      Anambra State, Nnewi 435101, Nigeria.
FAU - Nwaneli, C U
AU  - Nwaneli CU
FAU - Onwubere, B J
AU  - Onwubere BJ
FAU - Onwubuya, E I
AU  - Onwubuya EI
FAU - Ahaneku, G I
AU  - Ahaneku GI
LA  - eng
PT  - Journal Article
DEP - 20121010
PL  - United States
TA  - Int J Nephrol
JT  - International journal of nephrology
JID - 101546753
PMC - PMC3474970
EDAT- 2012/10/25 06:00
MHDA- 2012/10/25 06:01
CRDT- 2012/10/25 06:00
PHST- 2012/07/30 00:00 [received]
PHST- 2012/09/15 00:00 [revised]
PHST- 2012/09/16 00:00 [accepted]
PHST- 2012/10/25 06:00 [entrez]
PHST- 2012/10/25 06:00 [pubmed]
PHST- 2012/10/25 06:01 [medline]
AID - 10.1155/2012/769103 [doi]
PST - ppublish
SO  - Int J Nephrol. 2012;2012:769103. doi: 10.1155/2012/769103. Epub 2012 Oct 10.


PMID- 23094003
OWN - NLM
STAT- MEDLINE
DCOM- 20131112
LR  - 20211021
IS  - 1866-0452 (Electronic)
IS  - 1866-0452 (Linking)
VI  - 109
IP  - 40
DP  - 2012 Oct
TI  - Complex medical ethical problems.
PG  - 665; author reply 666
LID - 10.3238/arztebl.2012.0665a [doi]
FAU - Sehlen, Susanne
AU  - Sehlen S
FAU - Schafer, Christof
AU  - Schafer C
LA  - eng
PT  - Letter
PT  - Comment
DEP - 20121005
PL  - Germany
TA  - Dtsch Arztebl Int
JT  - Deutsches Arzteblatt international
JID - 101475967
SB  - IM
CON - Dtsch Arztebl Int. 2012 Feb;109(8):141-7. PMID: 22419955
MH  - *Attitude of Health Personnel
MH  - *Ethics, Medical
MH  - Female
MH  - Humans
MH  - Male
MH  - *Moral Obligations
MH  - Terminal Care/*ethics
PMC - PMC3476614
EDAT- 2012/10/25 06:00
MHDA- 2013/11/13 06:00
CRDT- 2012/10/25 06:00
PHST- 2012/10/25 06:00 [entrez]
PHST- 2012/10/25 06:00 [pubmed]
PHST- 2013/11/13 06:00 [medline]
AID - 10.3238/arztebl.2012.0665a [doi]
PST - ppublish
SO  - Dtsch Arztebl Int. 2012 Oct;109(40):665; author reply 666. doi:
      10.3238/arztebl.2012.0665a. Epub 2012 Oct 5.


PMID- 23093895
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121025
LR  - 20211021
IS  - 1174-2704 (Electronic)
IS  - 1174-2704 (Linking)
VI  - 5
IP  - 1
DP  - 2012 Jul
TI  - The Vanuatu medical supply system - documenting opportunities and challenges to
      meet the Millennium Development Goals.
PG  - 14-21
AB  - OBJECTIVES: Limited human resources are widely recognised as a barrier to achieve
      health-related Millennium Development Goals. Availability of medical supplies and
      suitably trained health personnel are crucial to ensuring a well-functioning
      medical supply system. The objective of this paper is to identify the factors
      which influence the availability of medical supplies within the health facilities
      of Vanuatu. METHODS: A qualitative triangulated strategy using semi-structured
      interviews, observational workplace surveys and semi-structured focus groups was 
      developed. This research was approved by the Human Ethics Committee of the
      University of Canberra and was funded through a direct grant from the United
      Nations Population Fund Suva, Pacific sub regional office. RESULTS: During two
      weeks of data collection, 21 interviews were conducted, observational workplace
      surveys were completed in 19 facilities and 22 personnel participated in three
      focus groups across three provinces. The interviewees had a wide range of primary
      professional groupings and were representative of the Vanuatu health workforce. A
      complex array of medical supply issues are described from within the three tiered
      structure of the medical supply system. CONCLUSION: The results of this research 
      have further informed our understanding of the competencies required by
      healthcare personnel to conduct medical supply management activities effectively 
      in Pacific Island countries. As a result of this research, a platform is provided
      for the government of Vanuatu to engage development partners to work toward a
      sustainable medical supply system.
FAU - Brown, Andrew
AU  - Brown A
AD  - Discipline of Pharmacy, Faculty of Health, University of Canberra, Canberra,
      Australia.
FAU - Gilbert, Ben
AU  - Gilbert B
LA  - eng
PT  - Journal Article
DEP - 20120723
PL  - New Zealand
TA  - South Med Rev
JT  - Southern med review
JID - 101571840
PMC - PMC3471189
OTO - NOTNLM
OT  - Essential medicines supply
OT  - Vanuatu
OT  - interview
OT  - medical supply
OT  - pharmacy
OT  - surveys
EDAT- 2012/10/25 06:00
MHDA- 2012/10/25 06:01
CRDT- 2012/10/25 06:00
PHST- 2012/10/25 06:00 [entrez]
PHST- 2012/10/25 06:00 [pubmed]
PHST- 2012/10/25 06:01 [medline]
PST - ppublish
SO  - South Med Rev. 2012 Jul;5(1):14-21. Epub 2012 Jul 23.


PMID- 23093894
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121025
LR  - 20211021
IS  - 1174-2704 (Electronic)
IS  - 1174-2704 (Linking)
VI  - 5
IP  - 1
DP  - 2012 Jul
TI  - The burden of adverse events during treatment of drug-resistant tuberculosis in
      Namibia.
PG  - 6-13
AB  - OBJECTIVE: Namibia faces a dual burden of HIV/AIDS and tuberculosis (TB). In
      2010, HIV prevalence was 18.8%, the TB case notification rate was 634 cases per
      100,000 population and the TB/HIV co-infection rate was 58%. There were 372 cases
      of drug-resistant TB (DR-TB) in 2009. The objective of this study was to assess
      the prevalence, profile and outcome of adverse events (AEs) associated with
      treatment of DR-TB and to explore possible influences of HIV disease on the
      occurrence of adverse events. METHODS: This was a cross-sectional descriptive
      study. After ethical approval, data were collected from treatment records of all 
      patients treated for DR-TB at the study facility between January 2008 and
      February 2010 using a structured data collection form. RESULTS: A total of 141
      adverse events of varying severity were experienced in 90% (53/59) of
      patients.The TB/HIV co-infection rate was 53% (n=31). The prevalence of
      gastrointestinal tract adverse events (abdominal pains, constipation, diarrhea,
      nausea and vomiting) was 64%, tinnitus 45%, joint pain 28%and decreased hearing
      25%. Abdominal pains, rash, nausea, decreased hearing and joint pain were more
      common in HIV infected than in HIV uninfected patients. CONCLUSIONS: Adverse
      events of varying severity are common during treatment of DR-TB, particularly in 
      the intensive phase of therapy. Some adverse events were more prevalent in DR-TB 
      patients co-infected with HIV. The study concludes that the characteristics and
      risk factors of serious adverse events should be further examined.
FAU - Sagwa, Evans
AU  - Sagwa E
AD  - School of Public Health, University of the Western Cape, Cape Town, South Africa 
      ; Utrecht Institute for Pharmaceutical Sciences, Division of Pharmacoepidemiology
      and Clinical Pharmacology, Utrecht University, Utrecht, the Netherlands ;
      Management Sciences for Health, Strengthening Pharmaceutical Systems Program,
      Namibia.
FAU - Mantel-Teeuwisse, Aukje Kaija
AU  - Mantel-Teeuwisse AK
FAU - Ruswa, Nunurai
AU  - Ruswa N
FAU - Musasa, Jean Paul
AU  - Musasa JP
FAU - Pal, Shanthi
AU  - Pal S
FAU - Dhliwayo, Panganai
AU  - Dhliwayo P
FAU - van Wyk, Brian
AU  - van Wyk B
LA  - eng
PT  - Journal Article
DEP - 20120723
PL  - New Zealand
TA  - South Med Rev
JT  - Southern med review
JID - 101571840
PMC - PMC3471190
OTO - NOTNLM
OT  - Namibia
OT  - adverse events
OT  - drug resistance
OT  - second-line drugs
OT  - tuberculosis
EDAT- 2012/10/25 06:00
MHDA- 2012/10/25 06:01
CRDT- 2012/10/25 06:00
PHST- 2012/10/25 06:00 [entrez]
PHST- 2012/10/25 06:00 [pubmed]
PHST- 2012/10/25 06:01 [medline]
PST - ppublish
SO  - South Med Rev. 2012 Jul;5(1):6-13. Epub 2012 Jul 23.


PMID- 23093831
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121025
LR  - 20211021
IS  - 1998-3735 (Electronic)
IS  - 0973-1075 (Linking)
VI  - 18
IP  - 2
DP  - 2012 May
TI  - Gabapentin in the treatment of persistent hiccups in advanced malignancy.
PG  - 138-40
LID - 10.4103/0973-1075.100839 [doi]
AB  - Hiccups are a distressing symptom in advanced malignancies in the setting of
      palliative care. A case of persistent hiccups treated with oral Gabapentin is
      presented to highlight the clinical and ethical dilemmas in patients with
      advanced malignancy. A 70-year-old male with non-small cell cancer of the lung
      with widespread metastases presented with persistent hiccups. The patient and
      family sought only symptom relief from home, without hospitalization or further
      investigations. The hiccups were dramatically relieved by oral Gabapentin,
      highlighting the recent reports that mention this molecule as being useful for
      hiccups. Gabapentin is a simple tool that may be utilized by palliative care
      physicians to relieve hiccups in advanced malignancies.
FAU - Menon, Mahesh
AU  - Menon M
AD  - Department of Pain Medicine and Palliative Care Services, Kokilaben Dhirubhai
      Ambani Hospital, Four bungalows, Andheri (West), Mumbai-53, India.
LA  - eng
PT  - Case Reports
PL  - United States
TA  - Indian J Palliat Care
JT  - Indian journal of palliative care
JID - 101261221
PMC - PMC3477368
OTO - NOTNLM
OT  - Gabapentin
OT  - Hiccups in malignancy
OT  - Persistent hiccups
EDAT- 2012/10/25 06:00
MHDA- 2012/10/25 06:01
CRDT- 2012/10/25 06:00
PHST- 2012/10/25 06:00 [entrez]
PHST- 2012/10/25 06:00 [pubmed]
PHST- 2012/10/25 06:01 [medline]
AID - 10.4103/0973-1075.100839 [doi]
AID - IJPC-18-138 [pii]
PST - ppublish
SO  - Indian J Palliat Care. 2012 May;18(2):138-40. doi: 10.4103/0973-1075.100839.


PMID- 23093517
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20161020
IS  - 1941-2479 (Electronic)
IS  - 1010-5395 (Linking)
VI  - 24
IP  - 5
DP  - 2012 Sep
TI  - Ethical assessment of national health insurance system of Korea.
PG  - 872-9
LID - 10.1177/1010539512462500 [doi]
AB  - The current adverse effects of the health insurance system in Korea are
      considered to be problems that arise from an insufficient reflection of the
      notion of respecting human rights. The ethical principles most commonly suggested
      and used in public health are the 4 principles suggested by Beauchamp and
      Childress in 1994. From the perspective of the community, these 4 principles of
      medical ethics can be expanded to resolve problems surrounding existing social
      systems from a socialistic standpoint. This article describes a flexible,
      easy-to-use model for incorporating the 4 medical ethics principles into the
      National Health Insurance System (NHIS). First, the principle of respect for
      autonomy involves respecting the decision-making capacities of autonomous medical
      consumers and providers and enabling individuals to make reasoned and informed
      choices. Second is the principle of good practice. The government and medical
      institutions should act in a way that benefits the health care consumers. The
      principle of prohibiting bad practice involves avoiding causing health problems. 
      The National Health Insurance Corporation and health care providers should not
      harm the health care consumers. Finally, the principle of justice is concerned
      with distributing benefits, risks, and costs fairly-that is, the notion that
      patients in similar positions should be treated in a similar manner. If these
      problems are solved, health system quality could be better and more accessible
      and sustainable. The ethical assessment of the NHIS could be a trial to match the
      4 medical ethics principles and the NHIS. It can be applied internationally to
      relevant policy makers in different settings.
FAU - Lee, Yuri
AU  - Lee Y
FAU - Kim, Soyoon
AU  - Kim S
FAU - Kim, Ganglip
AU  - Kim G
LA  - eng
PT  - Journal Article
PL  - China
TA  - Asia Pac J Public Health
JT  - Asia-Pacific journal of public health
JID - 8708538
SB  - IM
MH  - Ethics, Medical
MH  - Humans
MH  - National Health Programs/*ethics
MH  - Personal Autonomy
MH  - Professional Autonomy
MH  - Republic of Korea
MH  - Social Justice
EDAT- 2012/10/25 06:00
MHDA- 2013/02/13 06:00
CRDT- 2012/10/25 06:00
PHST- 2012/10/25 06:00 [entrez]
PHST- 2012/10/25 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
AID - 24/5/872 [pii]
AID - 10.1177/1010539512462500 [doi]
PST - ppublish
SO  - Asia Pac J Public Health. 2012 Sep;24(5):872-9. doi: 10.1177/1010539512462500.


PMID- 23093515
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20161020
IS  - 1941-2479 (Electronic)
IS  - 1010-5395 (Linking)
VI  - 24
IP  - 5
DP  - 2012 Sep
TI  - Globalization of public health law and ethics.
PG  - 851-5
LID - 10.1177/1010539512462501 [doi]
AB  - The Constitution of the World Health Organization (1946) states that the
      "enjoyment of the highest attainable standard of health is one of the fundamental
      rights of every human being without distinction of race, religion, political
      belief, economic or social position." The international legal framework for this 
      right was laid by the Universal Declaration of Human Rights (1948) and reaffirmed
      in the International Covenant on Economic, Social, and Cultural Rights (1966) and
      the Declaration of Alma-Ata (1978). In recent years, the framework has been
      developed on 10 key elements: national and international human rights, laws,
      norms, and standards; resource constraints and progressive realization;
      obligations of immediate effect; freedoms and entitlements; available,
      accessible, acceptable, and good quality; respect, protect, and fulfill;
      non-discrimination, equality, and vulnerability; active and informed
      participation; international assistance and cooperation; and monitoring and
      accountability. Whereas public health law plays an essential role in the
      protection and promotion of the right to health, the emergence of SARS (2003)
      highlighted the urgent need to reform national public health laws and
      international obligations relating to public health in order to meet the new
      realities of a globalized world, leading to the WHO Framework Convention on
      Tobacco Control (2003) and the revision of the WHO International Health
      Regulations (2005). The Asian Institute for Bioethics and Health Law, in
      conjunction with the Republic of Korea's Ministry of Health and Welfare and the
      WHO International Digest of Health Legislation, conducted a comparative legal
      analysis of national public health laws in various countries through a project
      entitled Domestic Profiles of Public/Population Health Legislation (2006), which 
      underscored the importance of recognizing the political and social contexts of
      distinct legal cultures, including Western, Asian, Islamic, and African.
FAU - Sohn, Myongsei
AU  - Sohn M
AD  - Asian Institute for Bioethics and Health Law, Yonsei University, 50 Yonsei-Ro,
      Seodaemun-Gu, Seoul, Korea. msohn53@gmail.com
LA  - eng
PT  - Journal Article
PL  - China
TA  - Asia Pac J Public Health
JT  - Asia-Pacific journal of public health
JID - 8708538
SB  - IM
MH  - Constitution and Bylaws
MH  - Humans
MH  - *Internationality
MH  - Public Health/*ethics/*legislation & jurisprudence
MH  - World Health Organization
EDAT- 2012/10/25 06:00
MHDA- 2013/02/13 06:00
CRDT- 2012/10/25 06:00
PHST- 2012/10/25 06:00 [entrez]
PHST- 2012/10/25 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
AID - 24/5/851 [pii]
AID - 10.1177/1010539512462501 [doi]
PST - ppublish
SO  - Asia Pac J Public Health. 2012 Sep;24(5):851-5. doi: 10.1177/1010539512462501.


PMID- 23093514
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20161020
IS  - 1941-2479 (Electronic)
IS  - 1010-5395 (Linking)
VI  - 24
IP  - 5
DP  - 2012 Sep
TI  - Public health law and ethics.
PG  - 850
LID - 10.1177/1010539512462499 [doi]
FAU - Sohn, Myongsei
AU  - Sohn M
LA  - eng
PT  - Editorial
PT  - Introductory Journal Article
PL  - China
TA  - Asia Pac J Public Health
JT  - Asia-Pacific journal of public health
JID - 8708538
SB  - IM
MH  - Asia
MH  - Congresses as Topic
MH  - Humans
MH  - Pacific Islands
MH  - Public Health/*ethics/*legislation & jurisprudence
EDAT- 2012/10/25 06:00
MHDA- 2013/02/13 06:00
CRDT- 2012/10/25 06:00
PHST- 2012/10/25 06:00 [entrez]
PHST- 2012/10/25 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
AID - 24/5/850 [pii]
AID - 10.1177/1010539512462499 [doi]
PST - ppublish
SO  - Asia Pac J Public Health. 2012 Sep;24(5):850. doi: 10.1177/1010539512462499.


PMID- 23093513
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20161020
IS  - 1941-2479 (Electronic)
IS  - 1010-5395 (Linking)
VI  - 24
IP  - 5
DP  - 2012 Sep
TI  - Public health laws and ethics.
PG  - 848-9
LID - 10.1177/1010539512462498 [doi]
FAU - Low, Wah-Yun
AU  - Low WY
FAU - Binns, Colin
AU  - Binns C
LA  - eng
PT  - Editorial
PT  - Introductory Journal Article
PL  - China
TA  - Asia Pac J Public Health
JT  - Asia-Pacific journal of public health
JID - 8708538
SB  - IM
MH  - Asia
MH  - Congresses as Topic
MH  - Humans
MH  - Pacific Islands
MH  - Public Health/*ethics/*legislation & jurisprudence
EDAT- 2012/10/25 06:00
MHDA- 2013/02/13 06:00
CRDT- 2012/10/25 06:00
PHST- 2012/10/25 06:00 [entrez]
PHST- 2012/10/25 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
AID - 24/5/848 [pii]
AID - 10.1177/1010539512462498 [doi]
PST - ppublish
SO  - Asia Pac J Public Health. 2012 Sep;24(5):848-9. doi: 10.1177/1010539512462498.


PMID- 23093219
OWN - NLM
STAT- MEDLINE
DCOM- 20130524
LR  - 20121024
IS  - 1934-1563 (Electronic)
IS  - 1934-1482 (Linking)
VI  - 4
IP  - 10
DP  - 2012 Oct
TI  - Ethical challenges of caring for VIPs in the rehabilitation setting: Part II.
PG  - 773-7
LID - 10.1016/j.pmrj.2012.09.575 [doi]
LID - S1934-1482(12)01019-2 [pii]
FAU - Kirschner, Kristi L
AU  - Kirschner KL
AD  - Department of Medical Humanities and Bioethics, Northwestern University, Feinberg
      School of Medicine, 750 N Lake Shore, Drive, Chicago 60611, USA.
      k-kirschner@northwestern.edu
FAU - Francisco, Gerard E
AU  - Francisco GE
FAU - Josehart, Carl E
AU  - Josehart CE
FAU - Euliarte, Mary Ann
AU  - Euliarte MA
FAU - Neely, Kathy Johnson
AU  - Neely KJ
FAU - Kelly, Mark
AU  - Kelly M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - PM R
JT  - PM & R : the journal of injury, function, and rehabilitation
JID - 101491319
SB  - IM
MH  - Communication
MH  - *Ethics, Institutional
MH  - *Famous Persons
MH  - Humans
MH  - Patient Care Team
MH  - Privacy
MH  - Resource Allocation/ethics
MH  - Security Measures
EDAT- 2012/10/25 06:00
MHDA- 2013/05/28 06:00
CRDT- 2012/10/25 06:00
PHST- 2012/09/07 00:00 [received]
PHST- 2012/09/07 00:00 [accepted]
PHST- 2012/10/25 06:00 [entrez]
PHST- 2012/10/25 06:00 [pubmed]
PHST- 2013/05/28 06:00 [medline]
AID - S1934-1482(12)01019-2 [pii]
AID - 10.1016/j.pmrj.2012.09.575 [doi]
PST - ppublish
SO  - PM R. 2012 Oct;4(10):773-7. doi: 10.1016/j.pmrj.2012.09.575.


PMID- 23092717
OWN - NLM
STAT- MEDLINE
DCOM- 20140320
LR  - 20130802
IS  - 1878-1632 (Electronic)
IS  - 1529-9430 (Linking)
VI  - 13
IP  - 8
DP  - 2013 Aug
TI  - Conflict of interest and professional medical associations: the North American
      Spine Society experience.
PG  - 974-9
LID - 10.1016/j.spinee.2012.08.019 [doi]
LID - S1529-9430(12)00553-0 [pii]
AB  - BACKGROUND CONTEXT: Recently the financial relationships between industry and
      professional medical associations have come under increased scrutiny because of
      the concern that industry ties may create real or perceived conflicts of
      interest. Professional medical associations pursue public advocacy as well as
      promote medical education, develop clinical practice guidelines, fund research,
      and regulate professional conduct. Therefore, the conflicts of interest of a
      professional medical association and its leadership can have more far-reaching
      effects on patient care than those of an individual physician. PURPOSE: Few if
      any professional medical associations have reported their experience with
      implementing strict divestment and disclosure policies, and among the policies
      that have been issued, there is little uniformity. We describe the experience of 
      the North American Spine Society (NASS) in implementing comprehensive conflicts
      of interest policies. STUDY DESIGN: A special feature article. METHODS: We
      discuss financial conflicts of interest as they apply to professional medical
      associations rather than to individual physicians. We describe the current
      policies of disclosure and divestment adopted by the NASS and how these policies 
      have evolved, been refined, and have had no detrimental impact on membership,
      attendance at annual meetings, finances, or leadership recruitment. No funding
      was received for this work. The authors report no potential
      conflict-of-interest-associated biases in the text. RESULTS: The NASS has shown
      that a professional medical association can manage its financial relationships
      with industry in a manner that minimizes influence and bias. CONCLUSIONS: The
      NASS experience can provide a template for other professional medical
      associations to help manage their own possible conflicts of interest issues.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Schofferman, Jerome A
AU  - Schofferman JA
AD  - SpineCare Medical Group, 1850 Sullivan Ave., Daly City, CA 94015, USA.
FAU - Eskay-Auerbach, Marjorie L
AU  - Eskay-Auerbach ML
FAU - Sawyer, Laura S
AU  - Sawyer LS
FAU - Herring, Stanley A
AU  - Herring SA
FAU - Arnold, Paul M
AU  - Arnold PM
FAU - Muehlbauer, Eric J
AU  - Muehlbauer EJ
LA  - eng
PT  - Journal Article
DEP - 20121023
PL  - United States
TA  - Spine J
JT  - The spine journal : official journal of the North American Spine Society
JID - 101130732
SB  - IM
MH  - Conflict of Interest/*economics
MH  - Disclosure/*ethics
MH  - Ethics, Medical
MH  - Humans
MH  - Physicians/economics/ethics
MH  - Societies, Medical/economics/*ethics
MH  - United States
OTO - NOTNLM
OT  - Conflicts of interest
OT  - Disclosure
OT  - Ethics
OT  - Professional societies
OT  - Research support
EDAT- 2012/10/25 06:00
MHDA- 2014/03/22 06:00
CRDT- 2012/10/25 06:00
PHST- 2012/07/20 00:00 [received]
PHST- 2012/08/11 00:00 [accepted]
PHST- 2012/10/25 06:00 [entrez]
PHST- 2012/10/25 06:00 [pubmed]
PHST- 2014/03/22 06:00 [medline]
AID - S1529-9430(12)00553-0 [pii]
AID - 10.1016/j.spinee.2012.08.019 [doi]
PST - ppublish
SO  - Spine J. 2013 Aug;13(8):974-9. doi: 10.1016/j.spinee.2012.08.019. Epub 2012 Oct
      23.


PMID- 23092239
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20220410
IS  - 1472-6831 (Electronic)
IS  - 1472-6831 (Linking)
VI  - 12
DP  - 2012 Oct 24
TI  - Acid production in dental plaque after exposure to probiotic bacteria.
PG  - 44
LID - 10.1186/1472-6831-12-44 [doi]
AB  - BACKGROUND: The increasing interest in probiotic lactobacilli in health
      maintenance has raised the question of potential risks. One possible side effect 
      could be an increased acidogenicity in dental plaque. The aim of this study was
      to investigate the effect of probiotic lactobacilli on plaque lactic acid (LA)
      production in vitro and in vivo. METHODS: In the first part (A), suspensions of
      two lactobacilli strains (L. reuteri DSM 17938, L. plantarum 299v) were added to 
      suspensions of supragingival dental plaque collected from healthy young adults
      (n=25). LA production after fermentation with either xylitol or fructose was
      analyzed. In the second part (B), subjects (n=18) were given lozenges with
      probiotic lactobacilli (L. reuteri DSM 17938 and ATCC PTA 5289) or placebo for
      two weeks in a double-blinded, randomized cross-over trial. The concentration of 
      LA in supragingival plaque samples was determined at baseline and after 2 weeks. 
      Salivary counts of mutans streptococci (MS) and lactobacilli were estimated with 
      chair-side methods. RESULTS: Plaque suspensions with L. reuteri DSM 17938
      produced significantly less LA compared with L. plantarum 299v or controls
      (p<0.05). Fructose gave higher LA concentrations than xylitol. In part B, there
      were no significant differences in LA production between baseline and follow up
      in any of the groups and no differences between test and placebo were displayed. 
      The salivary MS counts were not significantly altered during the intervention but
      the lactobacilli counts increased significantly in the test group (p<0.05).
      CONCLUSION: Lactic acid production in suspensions of plaque and probiotic
      lactobacilli was strain-dependant and the present study provides no evidence of
      an increase in plaque acidity by the supply of selected probiotic lactobacilli
      when challenged by fructose or xylitol. The study protocol was approved by The
      Danish National Committee on Biomedical Research Ethics (protocol no
      H-2-2010-112). TRIAL REGISTRATION: NCT01700712.
FAU - Keller, Mette K
AU  - Keller MK
AD  - Department of Odontology, Section of Cariology, Endodontics, Pediatric Dentistry 
      and Clinical Genetics, Faculty of Health Sciences, University of Copenhagen,
      Copenhagen, Denmark. mke@sund.ku.dk
FAU - Twetman, Svante
AU  - Twetman S
LA  - eng
SI  - ClinicalTrials.gov/NCT01700712
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20121024
PL  - England
TA  - BMC Oral Health
JT  - BMC oral health
JID - 101088684
RN  - 0 (Placebos)
RN  - 30237-26-4 (Fructose)
RN  - 33X04XA5AT (Lactic Acid)
RN  - VCQ006KQ1E (Xylitol)
SB  - IM
MH  - Adult
MH  - Bacterial Load
MH  - Bacteriological Techniques
MH  - Cross-Over Studies
MH  - DMF Index
MH  - Dental Plaque/*metabolism
MH  - Double-Blind Method
MH  - Female
MH  - Fermentation
MH  - Follow-Up Studies
MH  - Fructose/metabolism
MH  - Humans
MH  - Lactic Acid/*biosynthesis
MH  - Lactobacillus/*metabolism
MH  - Lactobacillus plantarum/metabolism
MH  - Lactobacillus reuteri/growth & development/metabolism
MH  - Male
MH  - Placebos
MH  - Probiotics/*metabolism
MH  - Saliva/microbiology
MH  - Spectrophotometry
MH  - Streptococcus mutans/growth & development
MH  - Xylitol/metabolism
PMC - PMC3504569
EDAT- 2012/10/25 06:00
MHDA- 2013/03/13 06:00
CRDT- 2012/10/25 06:00
PHST- 2011/12/05 00:00 [received]
PHST- 2012/10/17 00:00 [accepted]
PHST- 2012/10/25 06:00 [entrez]
PHST- 2012/10/25 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
AID - 1472-6831-12-44 [pii]
AID - 10.1186/1472-6831-12-44 [doi]
PST - epublish
SO  - BMC Oral Health. 2012 Oct 24;12:44. doi: 10.1186/1472-6831-12-44.


PMID- 23092057
OWN - NLM
STAT- MEDLINE
DCOM- 20121127
LR  - 20211021
IS  - 1330-0962 (Print)
IS  - 1330-0962 (Linking)
VI  - 22
IP  - 3
DP  - 2012
TI  - Biochemia medica appoints research integrity editor.
PG  - 271
AB  - Biochemia Medica has just established the Research integrity editor who will act 
      as the Editorial team member responsible for all matters related to the various
      aspects of scientific misconduct. The major reason for this is the increasing
      number of various types of scientific misconduct in manuscripts submitted to our 
      Journal. Research integrity editor will: a) strive to continuously raise
      awareness for research and publication integrity issues; b) educate our authors, 
      reviewers and readers, by providing educational articles on various topics
      related to responsible research and writing; c) aim to prevent unethical research
      and publication practices; and d) responsibly deal with research and publication 
      misconduct attempts in accordance with internationally accepted policies and
      recommendations. This initiative provides firm evidence of our commitment and
      respect for publishing ethical and responsible research. By this we hope to
      further increase the scientific quality of the journal content as well as the
      quality of the editorial work.
FAU - Simundic, Ana-Maria
AU  - Simundic AM
LA  - eng
PT  - Editorial
PL  - Croatia
TA  - Biochem Med (Zagreb)
JT  - Biochemia medica
JID - 9610305
SB  - IM
MH  - Publications/ethics
MH  - *Publishing
MH  - Scientific Misconduct/ethics
PMC - PMC3900055
EDAT- 2012/10/25 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/10/25 06:00
PHST- 2012/10/25 06:00 [entrez]
PHST- 2012/10/25 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.11613/bm.2012.028 [doi]
PST - ppublish
SO  - Biochem Med (Zagreb). 2012;22(3):271. doi: 10.11613/bm.2012.028.


PMID- 23092046
OWN - NLM
STAT- MEDLINE
DCOM- 20121204
LR  - 20220317
IS  - 0027-9684 (Print)
IS  - 0027-9684 (Linking)
VI  - 104
IP  - 7-8
DP  - 2012 Jul-Aug
TI  - Understanding participation by African Americans in cancer genetics research.
PG  - 324-30
AB  - PURPOSE: Understanding genetic factors that contribute to racial differences in
      cancer outcomes may reduce racial disparities in cancer morbidity and mortality. 
      Achieving this goal will be limited by low rates of African American
      participation in cancer genetics research. METHOD: We conducted a qualitative
      study with African American adults (n = 91) to understand attitudes about
      participating in cancer genetics research and to identify factors that are
      considered when making a decision about participating in this type of research.
      RESULTS: Participants would consider the potential benefits to themselves, family
      members, and their community when making a decision to participate in cancer
      genetics research. However, concerns about exploitation, distrust of researchers,
      and investigators' motives were also important to participation decisions.
      Individuals would also consider who has access to their personal information and 
      what would happen to these data. Side effects, logistical issues, and the
      potential to gain knowledge about health issues were also described as important 
      factors in decision making. CONCLUSION: African Americans may consider a number
      of ethical, legal, and social issues when making a decision to participate in
      cancer genetics research. These issues should be addressed as part of recruitment
      efforts.
FAU - McDonald, Jasmine A
AU  - McDonald JA
AD  - Center for Community-Based Research and Health. Disparities, Department of
      Psychiatry, University of Pennsylvania, Philadelphia, USA.
FAU - Barg, Frances K
AU  - Barg FK
FAU - Weathers, Benita
AU  - Weathers B
FAU - Guerra, Carmen E
AU  - Guerra CE
FAU - Troxel, Andrea B
AU  - Troxel AB
FAU - Domchek, Susan
AU  - Domchek S
FAU - Bowen, Deborah
AU  - Bowen D
FAU - Shea, Judy A
AU  - Shea JA
FAU - Halbert, Chanita Hughes
AU  - Halbert CH
LA  - eng
GR  - P30 CA016520/CA/NCI NIH HHS/United States
GR  - P50 HG004487/HG/NHGRI NIH HHS/United States
GR  - R01 HG004346/HG/NHGRI NIH HHS/United States
GR  - R01HG004346/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Natl Med Assoc
JT  - Journal of the National Medical Association
JID - 7503090
SB  - IM
MH  - Adult
MH  - *African Americans
MH  - *Attitude
MH  - *Decision Making
MH  - Female
MH  - Focus Groups
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/*ethnology/*genetics
MH  - *Patient Participation
MH  - Qualitative Research
PMC - PMC3760677
MID - NIHMS493541
EDAT- 2012/10/25 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/10/25 06:00
PHST- 2012/10/25 06:00 [entrez]
PHST- 2012/10/25 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - S0027-9684(15)30172-3 [pii]
AID - 10.1016/s0027-9684(15)30172-3 [doi]
PST - ppublish
SO  - J Natl Med Assoc. 2012 Jul-Aug;104(7-8):324-30. doi:
      10.1016/s0027-9684(15)30172-3.


PMID- 23091977
OWN - NLM
STAT- MEDLINE
DCOM- 20121204
LR  - 20121024
IS  - 0030-1876 (Print)
IS  - 0030-1876 (Linking)
VI  - 105
IP  - 8
DP  - 2012 Aug
TI  - Interfaces between electronic medical record (EMR/EHR) technology and people in
      American medicine: insight. imagination, and relationships in clinical practice.
PG  - 316-9
AB  - This paper explores the contexts and relationships in which EMR/EHR technology is
      used in healthcare settings. It approaches the EMR/EHR as an issue in clinical
      ethics. The author recognizes the immense contribution that healthcare
      informatics makes to coordinating and integrating medical care at the level of
      individual physician, nurse, and institutions. At the same time the author raises
      a cautionary note about some unrecognized dimensions of the use and experience of
      the EMR/EHR. The author argues that the EMR/EHR can consciously and unconsciously
      become an instrument of assembly line-like physician "productivity" and
      "production reports" that depersonalize patient and physician alike. Construed
      this way, the EMR/EHR can narrow the clinician's imagination, relationships,
      clinical decision-making, and documentation into oversimplified, and potentially 
      distorting, clinical narratives and categories such as fit into CPT, ICD-9, DRG, 
      DSM-IV and other codes, EBM protocols, and clinical algorithms. By contrast, the 
      author uses a vignette and one of his own clinical poems to illustrate the rich
      weave of relationship and meaning that are foreground rather than background in
      clinical assessment, decision-making, treatment, outcome, and satisfaction. The
      author concludes with a call to imaginatively use the EMR/EHR as an instrument of
      physician-patient communication, and to include in it and make available vital
      narrative data (evidence) about patient, family, culture, occupation,
      socioeconomic status, physician, disease, and their relationships.
FAU - Stein, Howard F
AU  - Stein HF
AD  - Department of Family and Preventive Medicine, University of Oklahoma Health
      Sciences Center, Oklahoma City, Oklahoma, USA. howard-stein@ouhsc.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Okla State Med Assoc
JT  - The Journal of the Oklahoma State Medical Association
JID - 7503043
SB  - IM
CIN - J Okla State Med Assoc. 2012 Sep;105(9):359. PMID: 23155844
MH  - Decision Making/ethics
MH  - Depersonalization
MH  - Documentation/ethics
MH  - Efficiency/ethics
MH  - Electronic Health Records/*ethics
MH  - Humans
MH  - Imagination
MH  - Narration
MH  - Professional-Patient Relations/*ethics
MH  - United States
EDAT- 2012/10/25 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/10/25 06:00
PHST- 2012/10/25 06:00 [entrez]
PHST- 2012/10/25 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
PST - ppublish
SO  - J Okla State Med Assoc. 2012 Aug;105(8):316-9.


PMID- 23091916
OWN - NLM
STAT- MEDLINE
DCOM- 20121204
LR  - 20220321
IS  - 0297-2964 (Print)
IS  - 0297-2964 (Linking)
IP  - 110
DP  - 2012 Sep
TI  - [Patient education: between complex knowledge, educators, heterogeneous learners 
      and multiple contexts].
PG  - 45-59
AB  - Therapeutic patient education questions the links between medical and social
      sciences through epistemological, praxeological, and ethical issues. Its
      development in France and abroad necessary invites to consider the complexity of 
      the particularities and variations of numerous contexts. The present contribution
      examines the theoretical foundations and the conditions required for the
      development of integrative learning situations, which involve both persons with
      chronic diseases and educators who have beneficiated from diverse socialisations.
      These learning situations have been worked out across three distinct stages:
      prerequisite analysis of specific knowledge at stake and of learners'
      representations preceding the thorough design of procedures that can yield
      results with heterogeneous individuals of various cultural and social origins.
      More than ten thousands persons have beneficiated from these learning situations 
      courses. Results underline the development of emerging social dynamics and
      organisations beyond the learning process. These analysis invite to the
      reflection on social and contextual dimensions of learning, on the access to
      knowledge for persons with chronic diseases and the opportunities to develop the 
      approach by diverse educators and trainers from various areas.
FAU - Balcou-Debussche, Maryvette
AU  - Balcou-Debussche M
AD  - Laboratoire LCF-Icare, Universite-IUFM de La Reunion.
      maryvette.balcou-debussche@univ-reunion.fr
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - L'education therapeutique: entre savoirs complexes, formateurs, apprenants
      heterogenes et contextes pluriels.
PL  - France
TA  - Rech Soins Infirm
JT  - Recherche en soins infirmiers
JID - 9715370
MH  - Humans
MH  - Patient Education as Topic/*organization & administration/statistics & numerical 
      data
EDAT- 2012/10/25 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/10/25 06:00
PHST- 2012/10/25 06:00 [entrez]
PHST- 2012/10/25 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
PST - ppublish
SO  - Rech Soins Infirm. 2012 Sep;(110):45-59.


PMID- 23091837
OWN - NLM
STAT- MEDLINE
DCOM- 20130116
LR  - 20211203
IS  - 1876-4347 (Electronic)
IS  - 1871-6784 (Linking)
VI  - 29
IP  - 6
DP  - 2012 Sep 15
TI  - The future of technologies for personalised medicine.
PG  - 625-33
AB  - Personalised medicine promises prediction, prevention and treatment of illness
      that is targeted to individuals' needs. New technologies for detailed biological 
      profiling of individuals at the molecular level have been crucial in initiating
      the move to personalised medicine; further novel technologies will be necessary
      if the vision is to become a reality. We will need to develop new technologies to
      collect and analyse data in a way that is not just linear but integrated
      (understanding system level functioning) and dynamic (understanding system in
      flux). Key factors in the development of technologies for personalised medicine
      are standardisation, integration and harmonisation. For example, the tools and
      processes for data collection and analysis must be standardised across research
      sites. Research activity at different sites must be integrated to maximise
      synergies, and scientific research must be integrated with healthcare to ensure
      effective translation. There must also be harmonisation between scientific
      practices in different research sites, between science and healthcare and between
      science, healthcare and wider society, including the ethical and regulatory
      frameworks, the prevailing political and cultural ethos and the expectations of
      patients/citizens.
FAU - Harvey, Alison
AU  - Harvey A
AD  - Finchley Court, Norwich, UK.
FAU - Brand, Angela
AU  - Brand A
FAU - Holgate, Stephen T
AU  - Holgate ST
FAU - Kristiansen, Lars V
AU  - Kristiansen LV
FAU - Lehrach, Hans
AU  - Lehrach H
FAU - Palotie, Aarno
AU  - Palotie A
FAU - Prainsack, Barbara
AU  - Prainsack B
LA  - eng
GR  - G0800766/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PL  - Netherlands
TA  - N Biotechnol
JT  - New biotechnology
JID - 101465345
SB  - IM
MH  - Health Information Systems
MH  - Health Resources
MH  - Humans
MH  - Precision Medicine/*methods/*trends
MH  - Translational Research, Biomedical
EDAT- 2012/10/24 06:00
MHDA- 2013/01/17 06:00
CRDT- 2012/10/24 06:00
PHST- 2012/10/24 06:00 [entrez]
PHST- 2012/10/24 06:00 [pubmed]
PHST- 2013/01/17 06:00 [medline]
AID - S1871-6784(12)00052-0 [pii]
AID - 10.1016/j.nbt.2012.03.009 [doi]
PST - ppublish
SO  - N Biotechnol. 2012 Sep 15;29(6):625-33. doi: 10.1016/j.nbt.2012.03.009.


PMID- 23091422
OWN - NLM
STAT- MEDLINE
DCOM- 20130314
LR  - 20211021
IS  - 1549-1676 (Electronic)
IS  - 1549-1277 (Linking)
VI  - 9
IP  - 10
DP  - 2012
TI  - Human rights research and ethics review: protecting individuals or protecting the
      state?
PG  - e1001325
LID - 10.1371/journal.pmed.1001325 [doi]
FAU - Amon, Joseph J
AU  - Amon JJ
AD  - Health and Human Rights Division, Human Rights Watch, New York, NY, USA.
      amonj@hrw.org
FAU - Baral, Stefan D
AU  - Baral SD
FAU - Beyrer, Chris
AU  - Beyrer C
FAU - Kass, Nancy
AU  - Kass N
LA  - eng
PT  - Journal Article
DEP - 20121016
PL  - United States
TA  - PLoS Med
JT  - PLoS medicine
JID - 101231360
SB  - IM
MH  - *Human Rights
MH  - Humans
MH  - *Research
PMC - PMC3472977
EDAT- 2012/10/24 06:00
MHDA- 2013/03/15 06:00
CRDT- 2012/10/24 06:00
PHST- 2012/10/24 06:00 [entrez]
PHST- 2012/10/24 06:00 [pubmed]
PHST- 2013/03/15 06:00 [medline]
AID - 10.1371/journal.pmed.1001325 [doi]
AID - PMEDICINE-D-12-01627 [pii]
PST - ppublish
SO  - PLoS Med. 2012;9(10):e1001325. doi: 10.1371/journal.pmed.1001325. Epub 2012 Oct
      16.


PMID- 23091174
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20121224
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 266
IP  - 1
DP  - 2013 Jan
TI  - Cognition and sensation in very high static magnetic fields: a randomized
      case-crossover study with different field strengths.
PG  - 236-45
LID - 10.1148/radiol.12112172 [doi]
AB  - PURPOSE: To establish the extent to which representative cognitive functions in
      subjects undergoing magnetic resonance (MR) imaging are acutely impaired by
      static magnetic fields of varying field strengths. MATERIALS AND METHODS: This
      study was approved by the local ethics committee, and informed consent was
      obtained from all subjects. In this single-blind case-crossover study, 41 healthy
      subjects underwent an extensive neuropsychologic examination while in MR units of
      differing field strengths (1.5, 3.0, and 7.0 T), including a mock imager with no 
      magnetic field as a control condition. Subjects were blinded to field strength.
      Tests were performed while subjects were lying still in the MR unit and while the
      examination table was moved. The tests covered a representative set of cognitive 
      functions, such as memory, eye-hand coordination, attention, reaction time, and
      visual discrimination. Subjective sensory perceptions were also assessed. Effects
      were analyzed with a repeated-measures analysis of variance; the within-subject
      factors were field strength (0, 1.5, 3.0, and 7.0 T) and state (static, dynamic).
      RESULTS: Static magnetic fields were not found to have a significant effect on
      cognitive function at any field strength. However, sensory perceptions did vary
      according to field strength. Dizziness, nystagmus, phosphenes, and head ringing
      were related to the strength of the static magnetic field. CONCLUSION: Static
      magnetic fields as high as 7.0 T did not have a significant effect on cognition.
CI  - RSNA, 2012
FAU - Heinrich, Angela
AU  - Heinrich A
AD  - Department of Cognitive and Clinical Neuroscience, Central Institute of Mental
      Health, Medical Faculty Mannheim, Heidelberg University, Square J5, D-68159
      Mannheim, Germany.
FAU - Szostek, Anne
AU  - Szostek A
FAU - Meyer, Patric
AU  - Meyer P
FAU - Nees, Frauke
AU  - Nees F
FAU - Rauschenberg, Jaane
AU  - Rauschenberg J
FAU - Grobner, Jens
AU  - Grobner J
FAU - Gilles, Maria
AU  - Gilles M
FAU - Paslakis, Georgios
AU  - Paslakis G
FAU - Deuschle, Michael
AU  - Deuschle M
FAU - Semmler, Wolfhard
AU  - Semmler W
FAU - Flor, Herta
AU  - Flor H
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20121022
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cognition/*radiation effects
MH  - Cognition Disorders/diagnosis/*etiology/physiopathology
MH  - Cross-Over Studies
MH  - Dose-Response Relationship, Radiation
MH  - Female
MH  - Humans
MH  - Magnetic Fields/*adverse effects
MH  - Magnetic Resonance Imaging/*adverse effects
MH  - Male
MH  - Radiation Dosage
MH  - Radiation Injuries/diagnosis/*etiology/physiopathology
MH  - Sensation/*radiation effects
MH  - Sensation Disorders/diagnosis/*etiology/physiopathology
MH  - Young Adult
EDAT- 2012/10/24 06:00
MHDA- 2013/02/13 06:00
CRDT- 2012/10/24 06:00
PHST- 2012/10/24 06:00 [entrez]
PHST- 2012/10/24 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
AID - radiol.12112172 [pii]
AID - 10.1148/radiol.12112172 [doi]
PST - ppublish
SO  - Radiology. 2013 Jan;266(1):236-45. doi: 10.1148/radiol.12112172. Epub 2012 Oct
      22.


PMID- 23090882
OWN - NLM
STAT- MEDLINE
DCOM- 20130507
LR  - 20200930
IS  - 1552-485X (Electronic)
IS  - 1552-4841 (Linking)
VI  - 159B
IP  - 8
DP  - 2012 Dec
TI  - Molecular genetics research in ADHD: ethical considerations concerning patients' 
      benefit and resource allocation.
PG  - 885-95
LID - 10.1002/ajmg.b.32111 [doi]
AB  - Immense resource allocations have led to great data output in genetic research.
      Concerning ADHD resources spent on genetic research are less than those spent on 
      clinical research. But there are successful efforts made to increase support for 
      molecular genetics research in ADHD. Concerning genetics no evidence based
      conclusive results have significant impact on prevention, diagnosis or treatment 
      yet. With regard to ethical aspects like the patients' benefit and limited
      resources the question arises if it is indicated to think about a new balance of 
      resource allocation between molecular genetics and non-genetics research in ADHD.
      An ethical reflection was performed focusing on recent genetic studies and
      reviews based on a selective literature search. There are plausible reasons why
      genetic research results in ADHD are somehow disappointing for clinical practice 
      so far. Researchers try to overcome these gaps systematically, without knowing
      what the potential future benefits for the patients might be. Non-genetic
      diagnostic/therapeutic research may lead to clinically relevant findings within a
      shorter period of time. On the other hand, non-genetic research in ADHD may be
      nurtured by genetic approaches. But, with the latter there exist significant
      risks of harm like stigmatization and concerns regarding data protection.
      Isolated speeding up resources of genetic research in ADHD seems questionable
      from an ethical point of view. There is a need to find a new balance of resource 
      allocation between genetic and non-genetic research in ADHD, probably by
      integrating genetics more systematically into clinical research. A
      transdisciplinary debate is recommended.
CI  - Copyright (c) 2012 Wiley Periodicals, Inc.
FAU - Rothenberger, Lillian Geza
AU  - Rothenberger LG
AD  - Institute for Ethics and History in Medicine, Center for Medicine, Society and
      Prevention, University of Tuebingen, Gartenstrasse, Tuebingen, Germany.
      geza.rothenberger@uni-tuebingen.de
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121022
PL  - United States
TA  - Am J Med Genet B Neuropsychiatr Genet
JT  - American journal of medical genetics. Part B, Neuropsychiatric genetics : the
      official publication of the International Society of Psychiatric Genetics
JID - 101235742
SB  - IM
MH  - Attention Deficit Disorder with
      Hyperactivity/*diagnosis/epidemiology/*genetics/prevention & control
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - *Ethics, Research
MH  - Genetic Predisposition to Disease
MH  - Health Priorities/economics/ethics
MH  - Humans
MH  - Research/economics
MH  - Resource Allocation/economics/*ethics
EDAT- 2012/10/24 06:00
MHDA- 2013/05/08 06:00
CRDT- 2012/10/24 06:00
PHST- 2012/04/27 00:00 [received]
PHST- 2012/10/02 00:00 [accepted]
PHST- 2012/10/24 06:00 [entrez]
PHST- 2012/10/24 06:00 [pubmed]
PHST- 2013/05/08 06:00 [medline]
AID - 10.1002/ajmg.b.32111 [doi]
PST - ppublish
SO  - Am J Med Genet B Neuropsychiatr Genet. 2012 Dec;159B(8):885-95. doi:
      10.1002/ajmg.b.32111. Epub 2012 Oct 22.


PMID- 23090562
OWN - NLM
STAT- MEDLINE
DCOM- 20130708
LR  - 20190818
IS  - 1873-233X (Electronic)
IS  - 0029-7844 (Linking)
VI  - 120
IP  - 5
DP  - 2012 Nov
TI  - ACOG Committee Opinion Number 541: Professional relationships with industry.
PG  - 1243-9
LID - http://10.1097/01.AOG.0000422589.22542.a9 [doi]
AB  - The American College of Obstetricians and Gynecologists (the College) has a long 
      history of leadership in ensuring that its educational mission is evidence based 
      and unbiased. A predecessor to this Committee Opinion was published in 1985,
      making the College one of the first professional associations to provide guidance
      on this issue. The College has continued to update the ethical guidance on
      physician interactions with industry periodically. Obstetrician-gynecologists'
      relationships with industry should be structured in a manner that will enhance,
      rather than detract from, their obligations to their patients. The ideal
      behaviors set forth in this Committee Opinion will contribute toward maintaining 
      patient trust in the specialty and avoiding conflicts of interest by College
      members.
CN  - Committee on Ethics
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Obstet Gynecol
JT  - Obstetrics and gynecology
JID - 0401101
SB  - IM
MH  - Conflict of Interest
MH  - Drug Industry/*ethics
MH  - Gynecology/*ethics
MH  - Humans
MH  - Obstetrics/*ethics
MH  - Physicians/*ethics
MH  - Professional Staff Committees
MH  - United States
MH  - Workforce
EDAT- 2012/10/24 06:00
MHDA- 2013/07/09 06:00
CRDT- 2012/10/24 06:00
PHST- 2012/10/24 06:00 [entrez]
PHST- 2012/10/24 06:00 [pubmed]
PHST- 2013/07/09 06:00 [medline]
AID - 10.1097/01.aog.0000422589.22542.a9 [doi]
AID - 00006250-201211000-00051 [pii]
PST - ppublish
SO  - Obstet Gynecol. 2012 Nov;120(5):1243-9. doi: 10.1097/01.aog.0000422589.22542.a9.


PMID- 23090232
OWN - NLM
STAT- MEDLINE
DCOM- 20130507
LR  - 20191210
IS  - 1806-9282 (Electronic)
IS  - 0104-4230 (Linking)
VI  - 58
IP  - 5
DP  - 2012 Sep-Oct
TI  - Traditional learning and problem-based learning: self-perception of preparedness 
      for internship.
PG  - 594-9
LID - S0104-42302012000500018 [pii]
AB  - OBJECTIVE: This study aims to evaluate Pontificia Universidade Catolica de Sao
      Paulo (PUC-SP) medical students' perception of their preparedness to attend the
      internship course by comparing students who entered the internship in 2009, who
      were taught according to the traditional learning method, and those who entered
      the internship in 2010, who were taught according to the new method, i.e.
      problem-based learning (PBL). METHODS: 50 traditional learning method students
      answered a standard Lickert scale questionnaire upon entering internship in 2009.
      In 2010, the process was repeated with PBL students. The questionnaire was based 
      upon the Preparation for Hospital Practice Questionnaire. This questionnaire was 
      evaluated by professors from three medical schools in Brazil regarding its
      applicability. The original questions were classified according to the importance
      these professors attributed to them, and less important questions were removed.
      Scores obtained from the Student's t-test were considered significant with p <
      0.05. RESULTS: A significant statistical difference was observed in 16 questions,
      and the traditional learning method students reported higher average scores. When
      questions were divided into dimensions, a significant statistical difference
      appeared in the dimensions " social aspects of health", "medical skills", and
      "ethical concepts"; traditional learning method students again reported higher
      scores (p < 0.001 for all dimensions). Higher scores were also reported when the 
      average of the answers to the whole questionnaire was calculated. CONCLUSION:
      Traditional learning method students consider themselves to be better prepared
      for internship activities than PBL students, according to the following three
      comparative means: by analyzing the answers to each question, by grouping these
      answers into dimensions, and by calculating the means of answers to the whole
      questionnaire.
FAU - Millan, Lais Pereira Bueno
AU  - Millan LP
AD  - School of Health and Medical Sciences, Pontificia Universidade Catolica de Sao
      Paulo, Sao Paulo, SP, Brazil. laismillan@uol.com.br
FAU - Semer, Beatriz
AU  - Semer B
FAU - Rodrigues, Jose Mauro da Silva
AU  - Rodrigues JM
FAU - Gianini, Reinaldo Jose
AU  - Gianini RJ
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PL  - Brazil
TA  - Rev Assoc Med Bras (1992)
JT  - Revista da Associacao Medica Brasileira (1992)
JID - 9308586
SB  - IM
MH  - Adult
MH  - Brazil
MH  - Clinical Competence
MH  - *Education, Medical
MH  - Female
MH  - Humans
MH  - *Internship and Residency
MH  - Male
MH  - Problem-Based Learning/*methods
MH  - *Self Concept
MH  - Students, Medical/*psychology
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2012/10/24 06:00
MHDA- 2013/05/08 06:00
CRDT- 2012/10/24 06:00
PHST- 2012/02/07 00:00 [received]
PHST- 2012/04/08 00:00 [accepted]
PHST- 2012/10/24 06:00 [entrez]
PHST- 2012/10/24 06:00 [pubmed]
PHST- 2013/05/08 06:00 [medline]
AID - S0104-42302012000500018 [pii]
PST - ppublish
SO  - Rev Assoc Med Bras (1992). 2012 Sep-Oct;58(5):594-9.


PMID- 23090016
OWN - NLM
STAT- MEDLINE
DCOM- 20140416
LR  - 20141009
IS  - 2164-5701 (Electronic)
IS  - 2164-5698 (Linking)
VI  - 4
IP  - 1
DP  - 2013 Jan-Mar
TI  - Experiences in sub-Saharan Africa with GM crop risk communication: outcome of a
      workshop.
PG  - 19-27
LID - 10.4161/gmcr.22488 [doi]
AB  - In tackling agricultural challenges, policy-makers in sub-Saharan Africa (SSA)
      have increasingly considered genetically modified (GM) crops as a potential tool 
      to increase productivity and to improve product quality. Yet, as elsewhere in the
      world, the adoption of GM crops in SSA has been marked by controversy,
      encompassing not only the potential risks to animal and human health, and to the 
      environment, but also other concerns such as ethical issues, public participation
      in decision-making, socio-economic factors and intellectual property rights. With
      these non-scientific factors complicating an already controversial situation,
      disseminating credible information to the public as well as facilitating
      stakeholder input into decision-making is essential. In SSA, there are various
      and innovative risk communication approaches and strategies being developed, yet 
      a comprehensive analysis of such data is missing. This gap is addressed by giving
      an overview of current strategies, identifying similarities and differences
      between various country and institutional approaches and promoting a way forward,
      building on a recent workshop with risk communicators working in SSA.
FAU - Racovita, Monica
AU  - Racovita M
AD  - Biosafety Unit, International Centre for Genetic Engineering and Biotechnology
      (ICGEB), Trieste, Italy.
FAU - Obonyo, Dennis Ndolo
AU  - Obonyo DN
FAU - Abdallah, Roshan
AU  - Abdallah R
FAU - Anguzu, Robert
AU  - Anguzu R
FAU - Bamwenda, Gratian
AU  - Bamwenda G
FAU - Kiggundu, Andrew
AU  - Kiggundu A
FAU - Maganga, Harrison
AU  - Maganga H
FAU - Muchiri, Nancy
AU  - Muchiri N
FAU - Nzeduru, Chinyere
AU  - Nzeduru C
FAU - Otadoh, Jane
AU  - Otadoh J
FAU - Rumjaun, Anwar
AU  - Rumjaun A
FAU - Suleiman, Iro
AU  - Suleiman I
FAU - Sunil, Manjusha
AU  - Sunil M
FAU - Tepfer, Mark
AU  - Tepfer M
FAU - Timpo, Samuel
AU  - Timpo S
FAU - van der Walt, Wynand
AU  - van der Walt W
FAU - Kabore-Zoungrana, Chantal
AU  - Kabore-Zoungrana C
FAU - Nfor, Lilian
AU  - Nfor L
FAU - Craig, Wendy
AU  - Craig W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120101
PL  - United States
TA  - GM Crops Food
JT  - GM crops & food
JID - 101572655
SB  - IM
MH  - Africa South of the Sahara
MH  - *Communication
MH  - Crops, Agricultural/*genetics
MH  - *Education
MH  - Humans
MH  - Plants, Genetically Modified
MH  - Risk Factors
OTO - NOTNLM
OT  - capacity-building needs
OT  - credibility
OT  - expertise
OT  - journalists
OT  - language
OT  - policy-makers
OT  - public participation
OT  - risk communication
OT  - scientists
OT  - stakeholders
EDAT- 2012/10/24 06:00
MHDA- 2014/04/17 06:00
CRDT- 2012/10/24 06:00
PHST- 2012/10/24 06:00 [entrez]
PHST- 2012/10/24 06:00 [pubmed]
PHST- 2014/04/17 06:00 [medline]
AID - 22488 [pii]
AID - 10.4161/gmcr.22488 [doi]
PST - ppublish
SO  - GM Crops Food. 2013 Jan-Mar;4(1):19-27. doi: 10.4161/gmcr.22488. Epub 2012 Jan 1.


PMID- 23089679
OWN - NLM
STAT- MEDLINE
DCOM- 20130521
LR  - 20220310
IS  - 1557-8615 (Electronic)
IS  - 0883-9441 (Linking)
VI  - 28
IP  - 1
DP  - 2013 Feb
TI  - Rates and determinants of informed consent: a case study of an international
      thromboprophylaxis trial.
PG  - 28-39
LID - 10.1016/j.jcrc.2012.08.005 [doi]
LID - S0883-9441(12)00252-3 [pii]
AB  - BACKGROUND: Successful completion of randomized trials depends upon efficiently
      and ethically screening patients and obtaining informed consent. Awareness of
      modifiable barriers to obtaining consent may inform ongoing and future trials.
      OBJECTIVE: The objective of this study is to describe and examine determinants of
      consent rates in an international heparin thromboprophylaxis trial (Prophylaxis
      for ThromboEmbolism in Critical Care Trial, clinicaltrials.gov NCT00182143).
      DESIGN: Throughout the 4-year trial, research personnel approached eligible
      critically ill patients or their substitute decision makers for informed consent.
      Whether consent was obtained or declined was documented daily. SETTING: The trial
      was conducted in 67 centers in 6 countries. MEASUREMENTS AND MAIN RESULTS: A
      total of 3764 patients were randomized. The overall consent rate was 82.2%
      (range, 50%-100%) across participating centers. Consent was obtained from
      substitute decision makers and patients in 90.1% and 9.9% of cases, respectively.
      Five factors were independently associated with consent rates. Research
      coordinators with more experience achieved higher consent rates (odds ratio [OR],
      3.43; 95% confidence interval, 2.42-4.86; P < .001 for those with >10 years of
      experience). Consent rates were higher in smaller intensive care units with less 
      than 15 beds compared with intensive care units with 15 to 20 beds, 21 to 25
      beds, and greater than 25 beds (all ORs, <0.5; P < .001) and were higher in
      centers with more than 1 full-time research staff (OR, 1.95; 95% confidence
      interval, 1.28-2.99; P < .001). Consent rates were lower in centers affiliated
      with the Canadian Critical Care Trials Group or the Australian and New Zealand
      Intensive Care Society Clinical Trials Group compared with other centers (OR,
      0.57; 95% confidence interval, 0.42-0.77; P < .001). Finally, consent rates were 
      highest during the pilot trial, lowest during the initiation of the full trial,
      and increased over years of recruitment (P < .001). CONCLUSIONS: Characteristics 
      of study centers, research infrastructure, and experience were important factors 
      associated with successfully procuring informed consent to participate in this
      thromboprophylaxis trial.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Smith, Orla M
AU  - Smith OM
AD  - Interdepartmental Division of Critical Care, Department of Medicine, University
      of Toronto, Toronto, Ontario, Canada.
FAU - McDonald, Ellen
AU  - McDonald E
FAU - Zytaruk, Nicole
AU  - Zytaruk N
FAU - Foster, Denise
AU  - Foster D
FAU - Matte, Andrea
AU  - Matte A
FAU - Clarke, France
AU  - Clarke F
FAU - Meade, Laurie
AU  - Meade L
FAU - O'Callaghan, Nicole
AU  - O'Callaghan N
FAU - Vallance, Shirley
AU  - Vallance S
FAU - Galt, Pauline
AU  - Galt P
FAU - Rajbhandari, Dorrilyn
AU  - Rajbhandari D
FAU - Rocha, Marcelo
AU  - Rocha M
FAU - Mehta, Sangeeta
AU  - Mehta S
FAU - Ferguson, Niall D
AU  - Ferguson ND
FAU - Hall, Richard
AU  - Hall R
FAU - Fowler, Robert
AU  - Fowler R
FAU - Burns, Karen
AU  - Burns K
FAU - Qushmaq, Ismael
AU  - Qushmaq I
FAU - Ostermann, Marlies
AU  - Ostermann M
FAU - Heels-Ansdell, Diane
AU  - Heels-Ansdell D
FAU - Cook, Deborah
AU  - Cook D
CN  - PROTECT Research Coordinators
CN  - PROTECT Investigators
CN  - Canadian Critical Care Trials Group
CN  - Australian, New Zealand Intensive Care Society Clinical Trials Group
LA  - eng
SI  - ClinicalTrials.gov/NCT00182143
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20121022
PL  - United States
TA  - J Crit Care
JT  - Journal of critical care
JID - 8610642
SB  - IM
MH  - *Guideline Adherence
MH  - Humans
MH  - *Informed Consent/ethics
MH  - Intensive Care Units
MH  - Logistic Models
MH  - Multivariate Analysis
MH  - Organizational Case Studies
MH  - *Randomized Controlled Trials as Topic/ethics
MH  - Thromboembolism/*prevention & control
MH  - *Vulnerable Populations
IR  - Cook D
FIR - Cook, Deborah
IR  - McDonald E
FIR - McDonald, Ellen
IR  - Tkaczyk A
FIR - Tkaczyk, Andrea
IR  - Clarke F
FIR - Clarke, France
IR  - Wallace C
FIR - Wallace, Christine
IR  - Hall R
FIR - Hall, Rick
IR  - Rocker G
FIR - Rocker, Graeme
IR  - Julien L
FIR - Julien, Lisa
IR  - Wright D
FIR - Wright, Debbie
IR  - Roy C
FIR - Roy, Caroline
IR  - Theriault J
FIR - Theriault, Judy
IR  - Pleasance S
FIR - Pleasance, Susan
IR  - Snow D
FIR - Snow, Debi
IR  - Herbert S
FIR - Herbert, Shannon
IR  - Meade M
FIR - Meade, Maureen
IR  - Hand L
FIR - Hand, Lori
IR  - Biljan M
FIR - Biljan, Maya
IR  - Freitag A
FIR - Freitag, Andreas
IR  - Wynne C
FIR - Wynne, Christine
IR  - Duffett M
FIR - Duffett, Mark
IR  - Kho M
FIR - Kho, Michelle
IR  - Zytaruk N
FIR - Zytaruk, Nicole
IR  - Currie K
FIR - Currie, Karen
IR  - Granton J
FIR - Granton, John
IR  - Matte A
FIR - Matte, Andrea
IR  - Farias P
FIR - Farias, Paulina
IR  - Chu L
FIR - Chu, Leslie
IR  - Brockest N
FIR - Brockest, Nancy
IR  - Go S
FIR - Go, Stephanie
IR  - McGrath-Chong M
FIR - McGrath-Chong, Margaret
IR  - Dennis M
FIR - Dennis, Madison
IR  - Lipkus M
FIR - Lipkus, Marc
IR  - Stern E
FIR - Stern, Emily
IR  - Albert R
FIR - Albert, Ryan
IR  - Seto R
FIR - Seto, Ron
IR  - Zuberi M
FIR - Zuberi, Muhammad
IR  - Ming J
FIR - Ming, Jie
IR  - Arus L
FIR - Arus, Laura
IR  - Walid M
FIR - Walid, Muhammad
IR  - Solek R
FIR - Solek, Robert
IR  - De Freitas K
FIR - De Freitas, Kim
IR  - Langevin S
FIR - Langevin, Stephan
IR  - Turgeon AF
FIR - Turgeon, Alexis F
IR  - Blais M
FIR - Blais, Martine
IR  - Lauzier F
FIR - Lauzier, Francois
IR  - Beauparlant M
FIR - Beauparlant, Maxime
IR  - Asselin J
FIR - Asselin, Julie
IR  - Roy C
FIR - Roy, Caroline
IR  - Gagne C
FIR - Gagne, Chantal
IR  - Thibodeau M
FIR - Thibodeau, Marie
IR  - Rioux A
FIR - Rioux, Anik
IR  - Tran TV
FIR - Tran, Tuong-Vi
IR  - Poirier G
FIR - Poirier, Germain
IR  - Neas I
FIR - Neas, Isabelle
IR  - Spearson S
FIR - Spearson, Sandrine
IR  - Ton B
FIR - Ton, Betty
IR  - McIntyre L
FIR - McIntyre, Lauralyn
IR  - Hebert P
FIR - Hebert, Paul
IR  - Watpool I
FIR - Watpool, Irene
IR  - McArdle T
FIR - McArdle, Tracy
IR  - Gaudert C
FIR - Gaudert, Claude
IR  - Marchand P
FIR - Marchand, Paule
IR  - Davidson C
FIR - Davidson, Carson
IR  - Dugal AM
FIR - Dugal, Anne-Marie
IR  - Fetzer S
FIR - Fetzer, Susan
IR  - Pagliarello J
FIR - Pagliarello, Joe
IR  - Lewis MJ
FIR - Lewis, Mary-Jo
IR  - Murphy E
FIR - Murphy, Erin
IR  - Foxall J
FIR - Foxall, Julia
IR  - Weir S
FIR - Weir, Sherry
IR  - Skrobik Y
FIR - Skrobik, Yoanna
IR  - Harvey J
FIR - Harvey, Johanne
IR  - Chitu S
FIR - Chitu, Stefania
IR  - Quach M
FIR - Quach, Marceline
IR  - Pinet L
FIR - Pinet, Linda
IR  - Albert M
FIR - Albert, Martin
IR  - Sirois C
FIR - Sirois, Carole
IR  - Nadon C
FIR - Nadon, Carole
IR  - Dolle S
FIR - Dolle, Stephanie
IR  - Gosselin AA
FIR - Gosselin, Audrey-Anne
IR  - Deroy P
FIR - Deroy, Patrice
IR  - Frenette AJ
FIR - Frenette, Anne Julie
IR  - Williamson D
FIR - Williamson, David
IR  - Mehta S
FIR - Mehta, Sangeeta
IR  - Ethier C
FIR - Ethier, Cheryl
IR  - Tirgari S
FIR - Tirgari, Sam
IR  - Steinberg L
FIR - Steinberg, Lindsay
IR  - McDonald R
FIR - McDonald, Rod
IR  - Sivanantham V
FIR - Sivanantham, Vidhya
IR  - Bandayrel K
FIR - Bandayrel, Kristofer
IR  - Pelletier FQ
FIR - Pelletier, Friederike Quittnat
IR  - Kramer-Kile M
FIR - Kramer-Kile, Marnie
IR  - Brown M
FIR - Brown, Maedean
IR  - Kim S
FIR - Kim, Scott
IR  - Leung H
FIR - Leung, Holly
IR  - Fowler R
FIR - Fowler, Robert
IR  - Marinoff N
FIR - Marinoff, Nicole
IR  - Code K
FIR - Code, Karen
IR  - Bojilov B
FIR - Bojilov, Boris
IR  - Parsotam D
FIR - Parsotam, Derek
IR  - Iazzetta J
FIR - Iazzetta, John
IR  - Marshall J
FIR - Marshall, John
IR  - Smith O
FIR - Smith, Orla
IR  - Fry B
FIR - Fry, Beth
IR  - Porretta K
FIR - Porretta, Kerri
IR  - Lee Y
FIR - Lee, Yoon
IR  - Morrissey J
FIR - Morrissey, Jeanna
IR  - Wen V
FIR - Wen, Victoria
IR  - Parsons L
FIR - Parsons, Laura
IR  - Kosinski A
FIR - Kosinski, Ann
IR  - Muscedere J
FIR - Muscedere, John
IR  - Fleury S
FIR - Fleury, Susan
IR  - Godfrey N
FIR - Godfrey, Nicole
IR  - Hammond S
FIR - Hammond, Sharlene
IR  - Mann E
FIR - Mann, Elizabeth
IR  - Myers M
FIR - Myers, Monica
IR  - Robinson A
FIR - Robinson, Amber
IR  - Grey C
FIR - Grey, Chris
IR  - Keenan S
FIR - Keenan, Sean
IR  - Reynolds S
FIR - Reynolds, Steven
IR  - Svetik M
FIR - Svetik, Miroslay
IR  - Van Osch M
FIR - Van Osch, Mary
IR  - Liberman AM
FIR - Liberman, Anne-Marie
IR  - Chittock D
FIR - Chittock, Dean
IR  - Dhingra V
FIR - Dhingra, Vinay
IR  - Gardner M
FIR - Gardner, Maureen
IR  - Logie S
FIR - Logie, Susan
IR  - Foster D
FIR - Foster, Denise
IR  - Autio R
FIR - Autio, Roger
IR  - Davies D
FIR - Davies, Dara
IR  - Ganz P
FIR - Ganz, Pia
IR  - Smith L
FIR - Smith, Laurie
IR  - Mattu K
FIR - Mattu, Kaldip
IR  - Mattu K
FIR - Mattu, Kaldip
IR  - Yip J
FIR - Yip, Judy
IR  - Dodek P
FIR - Dodek, Peter
IR  - Ashley BJ
FIR - Ashley, Betty Jean
IR  - Mans S
FIR - Mans, Sheilagh
IR  - Pavan M
FIR - Pavan, Mara
IR  - Doig C
FIR - Doig, Chip
IR  - Knox L
FIR - Knox, Linda
IR  - Wilson C
FIR - Wilson, Crystal
IR  - Champagne K
FIR - Champagne, Kevin
IR  - Peters AK
FIR - Peters, Angela Kayall
IR  - Ferguson N
FIR - Ferguson, Niall
IR  - Matte A
FIR - Matte, Andrea
IR  - Stevenson J
FIR - Stevenson, James
IR  - Elman J
FIR - Elman, Joel
IR  - Dennis M
FIR - Dennis, Madison
IR  - Tung J
FIR - Tung, Jenn
IR  - Solek R
FIR - Solek, Robert
IR  - De Freitas K
FIR - De Freitas, Kim
IR  - Pham N
FIR - Pham, Nga
IR  - Kutsogiannis J
FIR - Kutsogiannis, Jim
IR  - Thompson P
FIR - Thompson, Patrica
IR  - Lellouche F
FIR - Lellouche, Francois
IR  - Ferland MC
FIR - Ferland, Marie-Claude
IR  - Dussault P
FIR - Dussault, Patrick
IR  - Jacob C
FIR - Jacob, Caroline
IR  - Morneau ME
FIR - Morneau, Marie-Eve
IR  - Laberge N
FIR - Laberge, Nancy
IR  - Chateauvert N
FIR - Chateauvert, Nathalie
IR  - Karachi T
FIR - Karachi, Tim
IR  - Tkaczyk A
FIR - Tkaczyk, Andrea
IR  - Lourenco D
FIR - Lourenco, Diane
IR  - Jacka M
FIR - Jacka, Michael
IR  - Irwin M
FIR - Irwin, Marleen
IR  - Chan C
FIR - Chan, Carmen
IR  - Sonnema L
FIR - Sonnema, Leeca
IR  - Marsh K
FIR - Marsh, Kelly
IR  - Maurer J
FIR - Maurer, Jennifer
IR  - Kreidl T
FIR - Kreidl, Tamara
IR  - Varden C
FIR - Varden, Candice
IR  - Kinjerski C
FIR - Kinjerski, Carey
IR  - Carey N
FIR - Carey, Noelle
IR  - Doig C
FIR - Doig, Chip
IR  - Knox L
FIR - Knox, Linda
IR  - Wilson C
FIR - Wilson, Crystal
IR  - Champagne K
FIR - Champagne, Kevin
IR  - Peters AK
FIR - Peters, Angela Kayall
IR  - Khwaja K
FIR - Khwaja, Kosar
IR  - Banici L
FIR - Banici, Laura
IR  - Sirois C
FIR - Sirois, Carole
IR  - Havell L
FIR - Havell, Lena
IR  - Matte G
FIR - Matte, Gilbert
IR  - Normandin K
FIR - Normandin, Kathleen
IR  - Wood G
FIR - Wood, Gordon
IR  - Auld F
FIR - Auld, Fiona
IR  - Atkins L
FIR - Atkins, Leslie
IR  - Foster-Coull J
FIR - Foster-Coull, John
IR  - Lesur O
FIR - Lesur, Olivier
IR  - Lamontagne F
FIR - Lamontagne, Francois
IR  - Proulx S
FIR - Proulx, Sandra
IR  - Cloutier S
FIR - Cloutier, Sylvie
IR  - Bolduc B
FIR - Bolduc, Brigitte
IR  - Rousseau MP
FIR - Rousseau, Marie-Pierre
IR  - Leblond J
FIR - Leblond, Julie
IR  - Khwaja K
FIR - Khwaja, Kosar
IR  - Banici L
FIR - Banici, Laura
IR  - Sirois C
FIR - Sirois, Carole
IR  - Havell L
FIR - Havell, Lena
IR  - Matte G
FIR - Matte, Gilbert
IR  - Normandin K
FIR - Normandin, Kathleen
IR  - Hollinger G
FIR - Hollinger, Gerald
IR  - Shende V
FIR - Shende, Vasanti
IR  - Belcastro V
FIR - Belcastro, Vanessa
IR  - Martin J
FIR - Martin, Jane
IR  - Plaxton B
FIR - Plaxton, Bill
IR  - Foss A
FIR - Foss, Anders
IR  - McDougall H
FIR - McDougall, Heather
IR  - Morris S
FIR - Morris, Sharon
IR  - Petrovic G
FIR - Petrovic, Goran
IR  - Paunovic B
FIR - Paunovic, Bojan
IR  - Wiebe K
FIR - Wiebe, Kym
IR  - Marten N
FIR - Marten, Nicole
IR  - Sawatzky D
FIR - Sawatzky, Denise
IR  - Eisenstat J
FIR - Eisenstat, Jonathan
IR  - Doerle T
FIR - Doerle, Tammy
IR  - Skinner L
FIR - Skinner, Linda
IR  - Reynolds S
FIR - Reynolds, Steven
IR  - Keenan S
FIR - Keenan, Sean
IR  - Mans S
FIR - Mans, Sheilagh
IR  - Jang R
FIR - Jang, Ray
IR  - Sharpe M
FIR - Sharpe, Michael
IR  - Madady M
FIR - Madady, Mona
IR  - Mankanjee C
FIR - Mankanjee, Chandika
IR  - Cooper J
FIR - Cooper, Jamie
IR  - Davies A
FIR - Davies, Andrew
IR  - Vallance S
FIR - Vallance, Shirley
IR  - Weatherburn C
FIR - Weatherburn, Cindy
IR  - Board J
FIR - Board, Jasmin
IR  - Bennett V
FIR - Bennett, Victoria
IR  - Mak A
FIR - Mak, Anne
IR  - Chua SW
FIR - Chua, Sook Wern
IR  - Finfer S
FIR - Finfer, Simon
IR  - Ramakrishnan N
FIR - Ramakrishnan, Naresh
IR  - Bird S
FIR - Bird, Simon
IR  - Potter J
FIR - Potter, Julie
IR  - O'Connor A
FIR - O'Connor, Anne
IR  - Ankers S
FIR - Ankers, Susan
IR  - Gibson M
FIR - Gibson, Maggie
IR  - Cade J
FIR - Cade, Jack
IR  - Barge D
FIR - Barge, Deborah
IR  - Caf T
FIR - Caf, Tania
IR  - Howe B
FIR - Howe, Belinda
IR  - Michael E
FIR - Michael, Emma
IR  - Bellomo R
FIR - Bellomo, Rinaldo
IR  - Eastwood G
FIR - Eastwood, Glenn
IR  - Peck L
FIR - Peck, Leah
IR  - Goldsmith D
FIR - Goldsmith, Donna
IR  - O'Sullivan K
FIR - O'Sullivan, Kim
IR  - Ching M
FIR - Ching, Michael
IR  - Schmidt J
FIR - Schmidt, Jean
IR  - Ho M
FIR - Ho, Mei
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FIR - Lim, Bailey
IR  - Ernest D
FIR - Ernest, David
IR  - Radford S
FIR - Radford, Sam
IR  - Whitfield A
FIR - Whitfield, Ann
IR  - Cross A
FIR - Cross, Anthony
IR  - Eliott S
FIR - Eliott, Suzanne
IR  - Sidhu J
FIR - Sidhu, Jaspreet
IR  - Howe B
FIR - Howe, Belinda
IR  - Mercer I
FIR - Mercer, Inga
IR  - Hamilton A
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FIR - Yap, Pharmacist Chui
IR  - Crozier T
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FIR - Slobodian, Peter
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FIR - Woolfe, Clive
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FIR - Rajbhandari, Dorrilyn
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FIR - Boschert, Catherine
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FIR - Summers, Richard
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FIR - Reece, Graham
IR  - Sara T
FIR - Sara, Treena
IR  - Nand K
FIR - Nand, Kiran
IR  - Ibrahim R
FIR - Ibrahim, Rabsima
IR  - Bersten A
FIR - Bersten, Andrew
IR  - Gallus A
FIR - Gallus, Alex
IR  - Matheson E
FIR - Matheson, Elisha
IR  - O'Callaghan M
FIR - O'Callaghan, Margie
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FIR - Woolley, Kelly
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FIR - Orford, Neil
IR  - Elderkin T
FIR - Elderkin, Tania
IR  - Fraser M
FIR - Fraser, Melissa
IR  - Bone A
FIR - Bone, Allison
IR  - Salerno T
FIR - Salerno, Tania
IR  - Kinmonth A
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FIR - Muir, Paul
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FIR - Arora, Subhash
IR  - O'Bree B
FIR - O'Bree, Bridget
IR  - Shepherd K
FIR - Shepherd, Katherine
IR  - Gray K
FIR - Gray, Kerry
IR  - Vinh T
FIR - Vinh, Tu
IR  - Davey-Quinn A
FIR - Davey-Quinn, Alan
IR  - Sterba M
FIR - Sterba, Martin
IR  - Johnson BR
FIR - Johnson, Bronwyn Ruth
IR  - Xu R
FIR - Xu, Renee
IR  - Hill F
FIR - Hill, Francisco
IR  - Thompson J
FIR - Thompson, Julie
IR  - Ramadoss R
FIR - Ramadoss, Rajaram
IR  - Wood J
FIR - Wood, Josette
IR  - Yap ET
FIR - Yap, Eric Tah Wai
IR  - da Rocha MG
FIR - da Rocha, Marcelo Garcia
IR  - Kramer A
FIR - Kramer, Andrea
IR  - Hadrich M
FIR - Hadrich, Martha
IR  - Soares P
FIR - Soares, Patricia
IR  - Frosi F
FIR - Frosi, Fernando
IR  - Brandao N
FIR - Brandao, Nilton
IR  - Teixeira C
FIR - Teixeira, Cassiano
IR  - Roehrig C
FIR - Roehrig, Cintia
IR  - Zeni J
FIR - Zeni, Juliana
IR  - Panizzi D
FIR - Panizzi, Daniel
IR  - da Silva SA
FIR - da Silva, Suzana Alves
IR  - Filho RC
FIR - Filho, Rubens Costa
IR  - Moreira RC
FIR - Moreira, Renato Correa Alves
IR  - Gomes PN
FIR - Gomes, Plinio N
IR  - Biondi R
FIR - Biondi, Rodrigo
IR  - Caneca M
FIR - Caneca, Marcia
IR  - Berwanger O
FIR - Berwanger, Otavio
IR  - Silva G
FIR - Silva, Graziele
IR  - Romano E
FIR - Romano, Edson
IR  - Buehler AM
FIR - Buehler, Anna Maria
IR  - Murad M
FIR - Murad, Marcelo
IR  - Buononato P
FIR - Buononato, Paulo
IR  - Guimaraes HP
FIR - Guimaraes, Helio Penna
IR  - Lopes RD
FIR - Lopes, Renato D
IR  - Truffa A
FIR - Truffa, Adriano
IR  - Nakamura R
FIR - Nakamura, Rosana
IR  - Barbosa LM
FIR - Barbosa, Lillian Mazza
IR  - Nakamura RS
FIR - Nakamura, Rosana Suemi
IR  - Qushmaq I
FIR - Qushmaq, Ismael
IR  - Brennick J
FIR - Brennick, Jean
IR  - Bassi S
FIR - Bassi, Sawsan
IR  - Mukhtar A
FIR - Mukhtar, Amnah
IR  - Attas M
FIR - Attas, Majdah
IR  - Soliman A
FIR - Soliman, Amer
IR  - Alsultan M
FIR - Alsultan, Mohammed
IR  - Arabi Y
FIR - Arabi, Yaseen
IR  - Brits R
FIR - Brits, Riette
IR  - Cherfan A
FIR - Cherfan, Antoine
IR  - Alhashemi J
FIR - Alhashemi, Jamal
IR  - Shalabi S
FIR - Shalabi, Sanaa
IR  - Ainosah R
FIR - Ainosah, Randa
IR  - Mandourah Y
FIR - Mandourah, Yasser
IR  - Shaikh N
FIR - Shaikh, Nadeem
IR  - Shosho S
FIR - Shosho, Shatha
IR  - Al-Hazmi M
FIR - Al-Hazmi, Manal
IR  - Al-Azem M
FIR - Al-Azem, M Ali
IR  - Wyngaard T
FIR - Wyngaard, Trevor
IR  - Moustafa Y
FIR - Moustafa, Yahya
IR  - Klinger J
FIR - Klinger, James
IR  - Smithson B
FIR - Smithson, Barbara
IR  - Monckeberg A
FIR - Monckeberg, Andrea
IR  - Vlahakis NE
FIR - Vlahakis, Nicholas E
IR  - Meade L
FIR - Meade, Laurie
IR  - Bauer D
FIR - Bauer, Debbie
IR  - Cox M
FIR - Cox, Michael
IR  - O'Brien J
FIR - O'Brien, Jackie
IR  - Krause C
FIR - Krause, Catherine
IR  - Ahearn S
FIR - Ahearn, Sandra
IR  - Nates J
FIR - Nates, Joseph
IR  - Haque S
FIR - Haque, Sajid
IR  - Mooring D
FIR - Mooring, Deidre
IR  - Erfe R
FIR - Erfe, Rose
IR  - Nickerson P
FIR - Nickerson, Paula
IR  - McConnell K
FIR - McConnell, Kim
IR  - Ostermann M
FIR - Ostermann, Marlies
IR  - Treacher D
FIR - Treacher, David
IR  - Sherry T
FIR - Sherry, Tony
IR  - Smith J
FIR - Smith, John
IR  - Sanderson B
FIR - Sanderson, Barnaby
IR  - Ng J
FIR - Ng, Josephine
IR  - Brooks J
FIR - Brooks, John
IR  - Lim L
FIR - Lim, Ling
IR  - Lei K
FIR - Lei, Katie
IR  - Tunstell P
FIR - Tunstell, Paul
IR  - McKenzie C
FIR - McKenzie, Cathy
IR  - Cicirello F
FIR - Cicirello, Francesco
IR  - Schiff D
FIR - Schiff, David
IR  - Moody A
FIR - Moody, Allan
IR  - McDonald J
FIR - McDonald, Jennifer
IR  - Wills J
FIR - Wills, Judy
IR  - Bates S
FIR - Bates, Shannon
IR  - Shulman S
FIR - Shulman, Sam
IR  - Anderson D
FIR - Anderson, David
IR  - Kahn S
FIR - Kahn, Susan
IR  - Sobhi G
FIR - Sobhi, Gita
IR  - Zytaruk N
FIR - Zytaruk, Nicole
IR  - Saunders L
FIR - Saunders, Lois
IR  - Duchesne S
FIR - Duchesne, Suzanne
IR  - Southon J
FIR - Southon, Jennifer
IR  - Clarke F
FIR - Clarke, France
IR  - Barlow-Cash B
FIR - Barlow-Cash, Bronwyn
IR  - Krolicki K
FIR - Krolicki, Katherine
IR  - Luts K
FIR - Luts, Kristina
IR  - Kraus S
FIR - Kraus, Shelly
IR  - Bernotas A
FIR - Bernotas, Ashly
IR  - Yeo C
FIR - Yeo, Christa
IR  - Hoad N
FIR - Hoad, Neala
IR  - French T
FIR - French, Tammy
IR  - Heels-Ansdell D
FIR - Heels-Ansdell, Diane
IR  - Buckingham L
FIR - Buckingham, Lisa
IR  - Duraikannan A
FIR - Duraikannan, Aravin
IR  - Brown N
FIR - Brown, Norma
IR  - Cotoi C
FIR - Cotoi, Chris
IR  - Wang L
FIR - Wang, Luqi
IR  - Bhandari S
FIR - Bhandari, Sandeep
IR  - Grainger L
FIR - Grainger, Laurel
IR  - Maddock D
FIR - Maddock, Deborah
IR  - Smith P
FIR - Smith, Pat
IR  - Billington S
FIR - Billington, Shawn
IR  - Meade M
FIR - Meade, Maureen
IR  - Guyatt G
FIR - Guyatt, Gordon
IR  - Walter S
FIR - Walter, Stephen
IR  - Oronato L
FIR - Oronato, Linda
IR  - Cook D
FIR - Cook, Deborah
IR  - Cook D
FIR - Cook, Deborah
IR  - Crowther M
FIR - Crowther, Mark
IR  - Meade M
FIR - Meade, Maureen
IR  - Guyatt G
FIR - Guyatt, Gordon
IR  - Geerts W
FIR - Geerts, William
IR  - Cooper DJ
FIR - Cooper, D Jamie
IR  - Qushmaq I
FIR - Qushmaq, Ismael
IR  - Rocha M
FIR - Rocha, Marcelo
IR  - Berwanger O
FIR - Berwanger, Otavio
IR  - Warkentin TE
FIR - Warkentin, Theodore E
IR  - Zytaruk N
FIR - Zytaruk, Nicole
IR  - Vallance S
FIR - Vallance, Shirley
IR  - Heels-Ansdell D
FIR - Heels-Ansdell, Diane
IR  - Walter S
FIR - Walter, Stephen
IR  - Roberts R
FIR - Roberts, Robin
IR  - Brun-Buisson C
FIR - Brun-Buisson, Christian
IR  - Montori V
FIR - Montori, Victor
EDAT- 2012/10/24 06:00
MHDA- 2013/05/23 06:00
CRDT- 2012/10/24 06:00
PHST- 2012/06/24 00:00 [received]
PHST- 2012/08/12 00:00 [accepted]
PHST- 2012/10/24 06:00 [entrez]
PHST- 2012/10/24 06:00 [pubmed]
PHST- 2013/05/23 06:00 [medline]
AID - S0883-9441(12)00252-3 [pii]
AID - 10.1016/j.jcrc.2012.08.005 [doi]
PST - ppublish
SO  - J Crit Care. 2013 Feb;28(1):28-39. doi: 10.1016/j.jcrc.2012.08.005. Epub 2012 Oct
      22.


PMID- 23089615
OWN - NLM
STAT- MEDLINE
DCOM- 20130510
LR  - 20211021
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 75
IP  - 12
DP  - 2012 Dec
TI  - The duty to care in an influenza pandemic: a qualitative study of Canadian public
      perspectives.
PG  - 2425-30
LID - 10.1016/j.socscimed.2012.09.021 [doi]
LID - S0277-9536(12)00684-3 [pii]
AB  - Ever since the emergence of SARS, when we were reminded that the nature of health
      care practitioners' duty to care is greatly contested, it has remained a
      polarizing issue. Discussions on the nature and limits of health care
      practitioners' duty to care during disasters and public health emergencies
      abounds the literature, ripe with arguments seeking to ground its foundations.
      However, to date there has been little public engagement on this issue. This
      study involved three Townhall meetings held between February 2008 and May 2010 in
      three urban settings in Canada in order to probe lay citizens' views about
      ethical issues related to pandemic influenza, including issues surrounding the
      duty to care. Participants included Canadian residents aged 18 and over who were 
      fluent in English. Data were collected through day-long facilitated group
      discussions using case scenarios and focus group guides. Participant's views were
      organized according to several themes, including the following main themes (and
      respective sub-themes): 1. Legitimate limits; a) competing obligations; and b)
      appeal to personal choice; and 2. Legitimate expectations; a) reciprocity; and b)
      enforcement and planning. Our findings show that participants moved away from
      categorical notions of the duty to care towards more equivocal and often
      normative views throughout deliberations. Our analysis contributes a better
      understanding of the constitutive nature of the duty to care, defined in part by 
      taking account of public views. This broadened understanding can further inform
      the articulation of acceptable norms of duty to care and policy development
      efforts. What is more, it illustrates the urgent need for policy-makers and
      regulators to get clarity on obligations, responsibilities, and accountability in
      the execution of HCPs' duty to care during times of universal vulnerability.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Bensimon, Cecile M
AU  - Bensimon CM
AD  - University of Toronto, Joint Centre for Bioethics, 155 College Street, Suite 754,
      Toronto, ON M5T 1P8, Canada. cecile.bensimon@utoronto.ca
FAU - Smith, Maxwell J
AU  - Smith MJ
FAU - Pisartchik, Dmitri
AU  - Pisartchik D
FAU - Sahni, Sachin
AU  - Sahni S
FAU - Upshur, Ross E G
AU  - Upshur RE
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120926
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Canada/epidemiology
MH  - Female
MH  - Humans
MH  - Influenza, Human/*epidemiology/therapy
MH  - Male
MH  - Middle Aged
MH  - *Moral Obligations
MH  - *Pandemics
MH  - Patient Care/ethics
MH  - *Public Opinion
MH  - Qualitative Research
MH  - Young Adult
PMC - PMC7126096
EDAT- 2012/10/24 06:00
MHDA- 2013/05/11 06:00
CRDT- 2012/10/24 06:00
PHST- 2011/08/04 00:00 [received]
PHST- 2012/08/11 00:00 [revised]
PHST- 2012/09/13 00:00 [accepted]
PHST- 2012/10/24 06:00 [entrez]
PHST- 2012/10/24 06:00 [pubmed]
PHST- 2013/05/11 06:00 [medline]
AID - S0277-9536(12)00684-3 [pii]
AID - 10.1016/j.socscimed.2012.09.021 [doi]
PST - ppublish
SO  - Soc Sci Med. 2012 Dec;75(12):2425-30. doi: 10.1016/j.socscimed.2012.09.021. Epub 
      2012 Sep 26.


PMID- 23089606
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20161125
IS  - 0334-1763 (Print)
IS  - 0334-1763 (Linking)
VI  - 23
IP  - 4
DP  - 2012
TI  - Breaking away from dopamine deficiency: an essential new direction for
      Parkinson's disease.
PG  - 403-28
LID - 10.1515/revneuro-2012-0037 [doi]
LID - /j/revneuro.2012.23.issue-4/revneuro-2012-0037/revneuro-2012-0037.xml [pii]
AB  - For the past 40 years Parkinson's disease (PD) has been intrinsically associated 
      with dopamine (DA) deficiency of the nigrostriatal DA system. One of the
      fundamental strengths of this theoretical approach is based on a presumed
      relationship between the degree of DA deficiency and the severity of motor
      impairment in the disease and its models. However, detailed examination of a
      substantial number of exemplary preclinical and clinical studies reveals that any
      such interpretation is overoptimistic and suggests that DA deficiency may be
      merely an epiphenomenon of a larger process underlying this disorder. Such a
      conclusion is based on numerous examples of miscarriage of basic principles of
      good scientific practice including (i) failure to thoroughly examine the adverse 
      effects of DA replacement, (ii) drawing of statistical inference without
      recognising excessive spread of measure thereby lessening the importance of
      outliers, (iii) confounding independent and dependent variables within the
      scientific paradigm, (iv) overlooking fundamental principles of modern
      pharmacology, (v) confusing correlation with causation in linking cause and
      effect and (vi) disinclination to incorporate conflicting findings thereby
      infringing the quintessential scientific principle of tertium quid. This review
      demonstrates the inherent risks and dangers in the incontrovertible defence of DA
      deficiency theory and serves to address the ethical problems that emerge from the
      clinical application of scientific findings. There is increasing interest in new 
      directions for PD research by dimming down the current emphasis on the importance
      of DA deficiency and its replacement. This would provide genuine hope and a new
      direction for the sufferers of a most debilitating disease.
FAU - Willis, Gregory L
AU  - Willis GL
AD  - The Bronowski Institute of Behavioural Neuroscience, Coliban Medical Centre,
      Kyneton, Australia. director@bronowski.org
FAU - Moore, Cleo
AU  - Moore C
FAU - Armstrong, Stuart M
AU  - Armstrong SM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Germany
TA  - Rev Neurosci
JT  - Reviews in the neurosciences
JID - 8711016
RN  - 0 (Dopamine Agents)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Brain/diagnostic imaging/metabolism
MH  - Deep Brain Stimulation/methods
MH  - Dopamine/*deficiency
MH  - Dopamine Agents/therapeutic use
MH  - Humans
MH  - Neuroimaging
MH  - Parkinson Disease/*metabolism/pathology/therapy
MH  - Radionuclide Imaging
EDAT- 2012/10/24 06:00
MHDA- 2012/11/14 06:00
CRDT- 2012/10/24 06:00
PHST- 2012/01/11 00:00 [received]
PHST- 2012/04/15 00:00 [accepted]
PHST- 2012/10/24 06:00 [entrez]
PHST- 2012/10/24 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
AID - 10.1515/revneuro-2012-0037 [doi]
AID - /j/revneuro.2012.23.issue-4/revneuro-2012-0037/revneuro-2012-0037.xml [pii]
PST - ppublish
SO  - Rev Neurosci. 2012;23(4):403-28. doi: 10.1515/revneuro-2012-0037.


PMID- 23089605
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20121023
IS  - 0334-1763 (Print)
IS  - 0334-1763 (Linking)
VI  - 23
IP  - 4
DP  - 2012
TI  - Inducible pluripotent stem cells for the treatment of ischemic stroke: current
      status and problems.
PG  - 393-402
LID - 10.1515/revneuro-2012-0042 [doi]
LID - /j/revneuro.2012.23.issue-4/revneuro-2012-0042/revneuro-2012-0042.xml [pii]
AB  - Despite dramatic advancements in medical and surgical care, effective clinical
      therapies for ischemic stroke are limited. Stem-cell transplantation has emerged 
      as a potential therapeutic approach for cell replacement in ischemic brain
      injuries. Inducible pluripotent stem cells (iPSCs) have become an alternative
      cell source for transplantation. They possess efficient capacities for neural
      differentiation without ethical and immune-rejection concerns. Substantial
      function of iPSCs in pre-clinical models of ischemic brain injury has been
      observed. However, several problems remain regarding the treatment of ischemic
      stroke with iPSCs: tumorigenicity, poor iPSC derivation methods, and undefined
      delivery variables. With the development of iPSC research, safer and more
      effective strategies will be achieved for highly effective and tumor-free cell
      treatment of ischemic stroke.
FAU - Zhu, Yu
AU  - Zhu Y
AD  - Department of Neurosurgery, Zhejiang University, Zhejiang, China.
FAU - Wan, Shu
AU  - Wan S
FAU - Zhan, Ren-ya
AU  - Zhan RY
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Rev Neurosci
JT  - Reviews in the neurosciences
JID - 8711016
SB  - IM
MH  - Animals
MH  - Cell Differentiation
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*physiology
MH  - Stem Cell Transplantation/*methods
MH  - Stroke/*therapy
EDAT- 2012/10/24 06:00
MHDA- 2012/11/14 06:00
CRDT- 2012/10/24 06:00
PHST- 2012/04/02 00:00 [received]
PHST- 2012/05/04 00:00 [accepted]
PHST- 2012/10/24 06:00 [entrez]
PHST- 2012/10/24 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
AID - 10.1515/revneuro-2012-0042 [doi]
AID - /j/revneuro.2012.23.issue-4/revneuro-2012-0042/revneuro-2012-0042.xml [pii]
PST - ppublish
SO  - Rev Neurosci. 2012;23(4):393-402. doi: 10.1515/revneuro-2012-0042.


PMID- 23089561
OWN - NLM
STAT- MEDLINE
DCOM- 20130104
LR  - 20190722
IS  - 1488-2361 (Electronic)
IS  - 0846-5371 (Linking)
VI  - 63
IP  - 4
DP  - 2012 Nov
TI  - Ethics committees and research: an unintentional barrier?
PG  - 231-2
LID - 10.1016/j.carj.2012.09.001 [doi]
LID - S0846-5371(12)00096-4 [pii]
FAU - Munk, Peter L
AU  - Munk PL
FAU - Murphy, Kieran J
AU  - Murphy KJ
LA  - eng
PT  - Editorial
PL  - United States
TA  - Can Assoc Radiol J
JT  - Canadian Association of Radiologists journal = Journal l'Association canadienne
      des radiologistes
JID - 8812910
SB  - IM
MH  - *Ethics Committees, Research
MH  - Humans
MH  - Periodicals as Topic
MH  - Publishing/ethics
MH  - Radiology/*ethics
EDAT- 2012/10/24 06:00
MHDA- 2013/01/05 06:00
CRDT- 2012/10/24 06:00
PHST- 2012/10/24 06:00 [entrez]
PHST- 2012/10/24 06:00 [pubmed]
PHST- 2013/01/05 06:00 [medline]
AID - S0846-5371(12)00096-4 [pii]
AID - 10.1016/j.carj.2012.09.001 [doi]
PST - ppublish
SO  - Can Assoc Radiol J. 2012 Nov;63(4):231-2. doi: 10.1016/j.carj.2012.09.001.


PMID- 23089197
OWN - NLM
STAT- MEDLINE
DCOM- 20130418
LR  - 20121113
IS  - 1532-2777 (Electronic)
IS  - 0306-9877 (Linking)
VI  - 79
IP  - 6
DP  - 2012 Dec
TI  - A novel placebo-controlled clinical study design without ethical concerns - the
      free choice paradigm.
PG  - 880-2
LID - 10.1016/j.mehy.2012.09.017 [doi]
LID - S0306-9877(12)00440-9 [pii]
AB  - All doubled-blinded and placebo-controlled randomized drug trials carry the
      ethical limitation that up to 50% of patients are treated by an inert placebo
      pill for a prolonged period of time, and that treatment effects of the drug have 
      to be separated from unspecific (placebo) effects that also occur in the drug arm
      of the treatment. We propose the "free choice paradigm" (FCP) as an alternative. 
      It allows patients to choose between two pills identical in shape and colour of
      which one is the drug and the other is the placebo (in a double-blinded fashion),
      and drug efficacy is assessed as the difference in the number of events (days)
      one pill is chosen over the other. Advantages as well as disadvantages and
      limitations of the FCP still need to be assessed, as need the computational
      statistics to demonstrate superiority of drug over placebo. Ethical limitations
      are, however, minimized.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Enck, Paul
AU  - Enck P
AD  - Department of Psychosomatic Medicine, University Hospital Tubingen, Tubingen,
      Germany. paul.enck@uni-tuebingen.de
FAU - Grundy, David
AU  - Grundy D
FAU - Klosterhalfen, Sibylle
AU  - Klosterhalfen S
LA  - eng
PT  - Journal Article
DEP - 20121022
PL  - United States
TA  - Med Hypotheses
JT  - Medical hypotheses
JID - 7505668
RN  - 0 (Placebos)
SB  - IM
MH  - Clinical Trials as Topic
MH  - *Ethics
MH  - Humans
MH  - Models, Theoretical
MH  - Placebos
EDAT- 2012/10/24 06:00
MHDA- 2013/04/20 06:00
CRDT- 2012/10/24 06:00
PHST- 2012/07/30 00:00 [received]
PHST- 2012/09/11 00:00 [revised]
PHST- 2012/09/23 00:00 [accepted]
PHST- 2012/10/24 06:00 [entrez]
PHST- 2012/10/24 06:00 [pubmed]
PHST- 2013/04/20 06:00 [medline]
AID - S0306-9877(12)00440-9 [pii]
AID - 10.1016/j.mehy.2012.09.017 [doi]
PST - ppublish
SO  - Med Hypotheses. 2012 Dec;79(6):880-2. doi: 10.1016/j.mehy.2012.09.017. Epub 2012 
      Oct 22.


PMID- 23089170
OWN - NLM
STAT- MEDLINE
DCOM- 20121220
LR  - 20191210
IS  - 0030-6002 (Print)
IS  - 0030-6002 (Linking)
VI  - 153
IP  - 43
DP  - 2012 Oct 28
TI  - [Assessment of multicultural sensitivity in patient care, based on a survey].
PG  - 1711-8
LID - 10.1556/OH.2012.29479 [doi]
AB  - INTRODUCTION: The internationalization of societies and the processes of
      globalization raise new challenges towards health provision systems, including
      professional, ethical, social, cultural and communicational references of nursing
      and nursing education. AIMS: In this study the authors wanted to answer the
      following question: To what extent are health care professionals aware of and
      able to respond to the new challenges? METHODS: As an investigation method, the
      authors used a questionnaire and made a comparative analysis of answers related
      to the knowledge, skills and attitude of BSc nurses and other health
      professionals who possess a secondary qualification. The questionnaire was
      compiled based on the internationally accepted and validated Transcultural Self
      Efficacy Test. With the permission of the authors of the test, some questions
      were adapted to the national conditions. The responses were evaluated by
      statistical methods. RESULTS: There were better results in the components of
      skills and attitude of BSc nurses but there was a very high number of
      professionals in both groups who either failed to have or could not meet the
      requirements and phenomena related to intercultural skills. CONCLUSIONS: The
      survey performed among nurses proved that there is a real demand for
      intercultural skills and knowledge related to expectations of the society. In
      order to improve the quality of health care, the development of these skills is
      necessary.
FAU - Pop, Marcel
AU  - Pop M
AD  - Semmelweis Egyetem Nemzetkozi Kapcsolatok Igazgatosaga, Budapest.
      pop.marcel@semmelweis-univ.hu
FAU - Hollos, Sandor
AU  - Hollos S
FAU - Meszaros, Judit
AU  - Meszaros J
LA  - hun
PT  - Journal Article
PT  - Validation Study
TT  - Az interkulturalitas megitelese az apolasban egy felmeres tapasztalatai alapjan.
PL  - Hungary
TA  - Orv Hetil
JT  - Orvosi hetilap
JID - 0376412
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Clinical Protocols
MH  - *Cultural Competency
MH  - *Cultural Diversity
MH  - Education, Nursing, Baccalaureate
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Health Personnel/standards/*statistics & numerical data
MH  - Humans
MH  - Hungary/epidemiology
MH  - Language
MH  - Male
MH  - Middle Aged
MH  - Nurses/statistics & numerical data
MH  - Reproducibility of Results
MH  - Self Efficacy
MH  - Surveys and Questionnaires
MH  - Translations
EDAT- 2012/10/24 06:00
MHDA- 2012/12/21 06:00
CRDT- 2012/10/24 06:00
PHST- 2012/10/24 06:00 [entrez]
PHST- 2012/10/24 06:00 [pubmed]
PHST- 2012/12/21 06:00 [medline]
AID - 9423045327876J76 [pii]
AID - 10.1556/OH.2012.29479 [doi]
PST - ppublish
SO  - Orv Hetil. 2012 Oct 28;153(43):1711-8. doi: 10.1556/OH.2012.29479.


PMID- 23089151
OWN - NLM
STAT- MEDLINE
DCOM- 20130108
LR  - 20181023
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 345
DP  - 2012 Oct 22
TI  - Ethics committee chairwoman is not obliged to reveal source of concerns about
      surgeon's work, judge rules.
PG  - e7130
LID - 10.1136/bmj.e7130 [doi]
LID - bmj.e7130 [pii]
FAU - Dyer, Clare
AU  - Dyer C
LA  - eng
PT  - News
DEP - 20121022
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
SB  - IM
MH  - Disclosure/*legislation & jurisprudence
MH  - *Ethics Committees, Research
MH  - Female
MH  - Humans
MH  - London
MH  - Male
MH  - Physicians
EDAT- 2012/10/24 06:00
MHDA- 2013/01/09 06:00
CRDT- 2012/10/24 06:00
PHST- 2012/10/24 06:00 [entrez]
PHST- 2012/10/24 06:00 [pubmed]
PHST- 2013/01/09 06:00 [medline]
AID - 10.1136/bmj.e7130 [doi]
PST - epublish
SO  - BMJ. 2012 Oct 22;345:e7130. doi: 10.1136/bmj.e7130.


PMID- 23089020
OWN - NLM
STAT- MEDLINE
DCOM- 20130425
LR  - 20121023
IS  - 1872-969X (Electronic)
IS  - 0146-6453 (Linking)
VI  - 41
IP  - 3-4
DP  - 2012 Oct-Dec
TI  - Biological basis for protection of the environment.
PG  - 208-17
LID - 10.1016/j.icrp.2012.06.019 [doi]
LID - S0146-6453(12)00034-6 [pii]
AB  - The approach to protection of the environment may vary considerably depending on 
      ethical basis, methodological approach, and identification of endpoints and
      protective targets. The International Commission on Radiological Protection
      (ICRP) reviewed these issues in Publication 91, 'A framework for assessing the
      impact of ionising radiation on non-human species', published in 2003. At the
      same time, ICRP proposed that a possible future ICRP system addressing
      environmental assessment and protection would focus on biota, that the system
      should be effect-based so that any reasoning about adequate protection would be
      derived from firm understanding of harm at different exposure levels, and that
      the system should be based on data sets for Reference Animals and Plants. ICRP
      has thus chosen to approach environmental protection on the basis of biology, and
      further developed the approach in Publications 103, 108 and 114. This paper
      explores the biological basis for the ICRP system of environmental protection
      from the viewpoints of: the effects endpoints of concern; the hierarchy of
      biological organisation; adequate and appropriate protective targets; and the
      derivation of benchmark dose (rates) to guide protective efforts.
CI  - Copyright (c) 2012. Published by Elsevier Ltd.
FAU - Larsson, C-M
AU  - Larsson CM
AD  - Australian Radiation Protection and Nuclear Safety Agency, PO Box 655, Miranda,
      NSW 1490, Australia. carl-magnus.larsson@arpansa.gov.au
LA  - eng
PT  - Journal Article
DEP - 20120912
PL  - England
TA  - Ann ICRP
JT  - Annals of the ICRP
JID - 7708044
SB  - IM
MH  - Animals
MH  - Guidelines as Topic
MH  - Humans
MH  - International Agencies
MH  - Invertebrates/radiation effects
MH  - Plants/radiation effects
MH  - *Radiation Dosage
MH  - Radiation Injuries/*prevention & control
MH  - Radiation Protection/*standards
MH  - *Radiation, Ionizing
MH  - Risk Assessment
MH  - Vertebrates
EDAT- 2012/10/24 06:00
MHDA- 2013/04/26 06:00
CRDT- 2012/10/24 06:00
PHST- 2012/10/24 06:00 [entrez]
PHST- 2012/10/24 06:00 [pubmed]
PHST- 2013/04/26 06:00 [medline]
AID - S0146-6453(12)00034-6 [pii]
AID - 10.1016/j.icrp.2012.06.019 [doi]
PST - ppublish
SO  - Ann ICRP. 2012 Oct-Dec;41(3-4):208-17. doi: 10.1016/j.icrp.2012.06.019. Epub 2012
      Sep 12.


PMID- 23089002
OWN - NLM
STAT- MEDLINE
DCOM- 20130425
LR  - 20121023
IS  - 1872-969X (Electronic)
IS  - 0146-6453 (Linking)
VI  - 41
IP  - 3-4
DP  - 2012 Oct-Dec
TI  - Application of the Commission's recommendations: the activities of ICRP Committee
      4.
PG  - 32-44
LID - 10.1016/j.icrp.2012.08.002 [doi]
LID - S0146-6453(12)00065-6 [pii]
AB  - Committee 4 of the International Commission on Radiological Protection (ICRP) is 
      responsible for developing principles, recommendations, and guidance on the
      protection of man against radiation exposure; and considering their practical
      application in all exposure situations. The Committee also acts as a major point 
      of contact between ICRP and other international organisations and professional
      bodies concerned with protection against ionising radiation. The current work of 
      the Committee involves the development of a series of reports on implementation
      of the 2007 Recommendations, and a reflection on the ethical foundations of the
      radiological protection system. Following the accident in Fukushima, Committee 4 
      also initiated an analysis of management of the consequences of the accident,
      with the objective of revising, if necessary, the Commission's publications on
      emergency and post-accident situations.
CI  - Copyright (c) 2012. Published by Elsevier Ltd.
FAU - Lochard, Jacques
AU  - Lochard J
AD  - Centre d'etude sur l'Evaluation de la Protection dans le domaine Nucleaire, 28
      rue de la Redoute, 92260 Fontenay-aux-Roses, France. lochard@cepn.asso.fr
LA  - eng
PT  - Journal Article
PL  - England
TA  - Ann ICRP
JT  - Annals of the ICRP
JID - 7708044
SB  - IM
MH  - Environmental Exposure
MH  - Guidelines as Topic
MH  - Humans
MH  - *International Agencies
MH  - Occupational Exposure
MH  - Radiation Injuries/*prevention & control
MH  - Radiation Monitoring
MH  - Radiation Protection/*standards
MH  - Radioactive Hazard Release/*prevention & control
EDAT- 2012/10/24 06:00
MHDA- 2013/04/26 06:00
CRDT- 2012/10/24 06:00
PHST- 2012/10/24 06:00 [entrez]
PHST- 2012/10/24 06:00 [pubmed]
PHST- 2013/04/26 06:00 [medline]
AID - S0146-6453(12)00065-6 [pii]
AID - 10.1016/j.icrp.2012.08.002 [doi]
PST - ppublish
SO  - Ann ICRP. 2012 Oct-Dec;41(3-4):32-44. doi: 10.1016/j.icrp.2012.08.002.


PMID- 23088847
OWN - NLM
STAT- MEDLINE
DCOM- 20130618
LR  - 20130211
IS  - 1832-4274 (Print)
IS  - 1832-4274 (Linking)
VI  - 16
IP  - 1
DP  - 2013 Feb
TI  - An update on the Italian Twin Register: advances in cohort recruitment, project
      building and network development.
PG  - 190-6
LID - 10.1017/thg.2012.85 [doi]
AB  - The Italian Twin Register has been in place for more than 10 years. Since its
      establishment, it has been focusing, on the one hand, on a continuous update of
      the existing information, and on the other hand, on new phenotypes and sample
      collection. Demographic data on about 140,000 twins have been updated using the
      municipality registries. The Italian Twin Register has been carrying out several 
      new studies during the last few years. A birth cohort of twins, Multiple Births
      Cohort Study, has been started and the enrollment is ongoing. For this cohort,
      data on pregnancy and birth are collected, and periodical follow-ups are made.
      DNA is being collected for the twins and their parents. In the area of behavioral
      genetics, most efforts have been directed to psychological well being assessed
      with self-reported tools. Research on age-related traits continues with studies
      on arteriosclerosis development, early biomarkers in mild cognitive impairment,
      and the relation between lifestyle habits and mutagen sensitivity. The Italian
      Twin Register biobanking has grown in its size and in its know-how in terms of
      both technical issues and ethical procedures implementation. Furthermore,
      attitudes toward biobank-based research, together with willingness and motivation
      for donation, are being investigated. A valuable key resource for the Italian
      Twin Register is the possibility of linking twin data with disease registries.
      This approach has been yielding several important results, such as the recent
      study on the heritability of type 1 diabetes.
FAU - Brescianini, Sonia
AU  - Brescianini S
AD  - National Centre for Epidemiology, Surveillance and Health Promotion, Istituto
      Superiore di Sanita, Rome, Italy. soni.brescianini@iss.it
FAU - Fagnani, Corrado
AU  - Fagnani C
FAU - Toccaceli, Virgilia
AU  - Toccaceli V
FAU - Medda, Emanuela
AU  - Medda E
FAU - Nistico, Lorenza
AU  - Nistico L
FAU - D'Ippolito, Cristina
AU  - D'Ippolito C
FAU - Alviti, Sabrina
AU  - Alviti S
FAU - Arnofi, Antonio
AU  - Arnofi A
FAU - Caffari, Bruno
AU  - Caffari B
FAU - Delfino, Davide
AU  - Delfino D
FAU - Ferri, Maurizio
AU  - Ferri M
FAU - Penna, Luana
AU  - Penna L
FAU - Salemi, Miriam
AU  - Salemi M
FAU - Sereni, Silvia
AU  - Sereni S
FAU - Serino, Laura
AU  - Serino L
FAU - Cotichini, Rodolfo
AU  - Cotichini R
FAU - Stazi, Maria A
AU  - Stazi MA
LA  - eng
PT  - Journal Article
PT  - Twin Study
DEP - 20121022
PL  - England
TA  - Twin Res Hum Genet
JT  - Twin research and human genetics : the official journal of the International
      Society for Twin Studies
JID - 101244624
SB  - IM
MH  - Adult
MH  - Biological Specimen Banks
MH  - Cohort Studies
MH  - Diseases in Twins/epidemiology/*genetics
MH  - Female
MH  - Humans
MH  - Italy/epidemiology
MH  - Male
MH  - *Patient Selection
MH  - Pregnancy
MH  - *Program Development
MH  - *Registries
MH  - Twins, Dizygotic/*genetics
MH  - Twins, Monozygotic/*genetics
EDAT- 2012/10/24 06:00
MHDA- 2013/06/19 06:00
CRDT- 2012/10/24 06:00
PHST- 2012/10/24 06:00 [entrez]
PHST- 2012/10/24 06:00 [pubmed]
PHST- 2013/06/19 06:00 [medline]
AID - S1832427412000850 [pii]
AID - 10.1017/thg.2012.85 [doi]
PST - ppublish
SO  - Twin Res Hum Genet. 2013 Feb;16(1):190-6. doi: 10.1017/thg.2012.85. Epub 2012 Oct
      22.


PMID- 23088684
OWN - NLM
STAT- MEDLINE
DCOM- 20130408
LR  - 20191210
IS  - 0022-0167 (Print)
IS  - 0022-0167 (Linking)
VI  - 59
IP  - 4
DP  - 2012 Oct
TI  - Managing difficulties in supervision: supervisors' perspectives.
PG  - 528-41
LID - 10.1037/a0030000 [doi]
AB  - Few studies have examined the practice wisdom of expert supervisors. This study
      addresses this gap by exploring how experienced supervisors manage difficulties
      in supervision in the context of the supervisory relationship. The supervisors
      were a purposive sample of 16 senior members of the profession with considerable 
      expertise in supervision. In-depth interviews were first conducted with the
      supervisors. An interpersonal process recall method was then used to explore
      their reflections on one of their DVD-recorded supervision sessions. Analysis of 
      transcripts was completed using a modified consensual qualitative research
      method. Major difficulties included the broad domains of supervisee competence
      and ethical behavior, supervisee characteristics, supervisor countertransference,
      and problems in the supervisory relationship. Supervisors managed these
      difficulties using 4 key approaches: relational (naming, validating, attuning,
      supporting, anticipating, exploring parallel process, acknowledging mistakes, and
      modeling); reflective (facilitating reflectivity, remaining mindful and
      monitoring, remaining patient and transparent, processing countertransference,
      seeking supervision, and case conceptualizing); confrontative (confronting
      tentatively, confronting directly, refusing/terminating supervision, taking
      formal action, referring to personal therapy, and becoming directive); and
      avoidant interventions (struggling on, withholding, and withdrawing). Two brief
      case studies illustrate the process of applying these strategies sequentially in 
      managing difficulties. The study highlights the importance of relational
      strategies to maintain an effective supervisory alliance, reflective
      strategies-particularly when difficulties pertain to clinical material and the
      supervisory relationship-and confrontative strategies with unhelpful supervisee
      characteristics and behaviors that impede supervision.
CI  - (c) 2012 APA, all rights reserved.
FAU - Grant, Jan
AU  - Grant J
AD  - School of Psychology and Speech Pathology, Curtin University, Perth, Western
      Australia 6845, Australia. j.grant@curtin.edu.au
FAU - Schofield, Margot J
AU  - Schofield MJ
FAU - Crawford, Sarah
AU  - Crawford S
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Couns Psychol
JT  - Journal of counseling psychology
JID - 2985124R
SB  - IM
MH  - Aged
MH  - Australia
MH  - Counseling/*education
MH  - Countertransference
MH  - Female
MH  - Humans
MH  - *Interpersonal Relations
MH  - Male
MH  - Middle Aged
MH  - *Problem Solving
MH  - Psychotherapy/*education
MH  - Qualitative Research
MH  - Social Support
MH  - *Staff Development
MH  - Teaching/*methods
MH  - United Kingdom
EDAT- 2012/10/24 06:00
MHDA- 2013/04/09 06:00
CRDT- 2012/10/24 06:00
PHST- 2012/10/24 06:00 [entrez]
PHST- 2012/10/24 06:00 [pubmed]
PHST- 2013/04/09 06:00 [medline]
AID - 2012-28121-002 [pii]
AID - 10.1037/a0030000 [doi]
PST - ppublish
SO  - J Couns Psychol. 2012 Oct;59(4):528-41. doi: 10.1037/a0030000.


PMID- 23088080
OWN - NLM
STAT- MEDLINE
DCOM- 20121106
LR  - 20121023
IS  - 1330-0164 (Print)
IS  - 1330-0164 (Linking)
VI  - 66
IP  - 1
DP  - 2012 Mar
TI  - [Medicolegal dilemmas on restraint use in delirious patients in intensive care
      unit].
PG  - 11-6
AB  - The use of physical or chemical restraint in delirious patients in the intensive 
      care unit (ICU) is related to an array of ethical and medicolegal dilemmas. In
      most cases, they arise from insufficient knowledge of the regulations in force or
      due to their vague wording. The aim of this review article is to outline the
      basic views of the medical profession regarding restraint use as a method in the 
      treatment of delirium and to give an insight into the existing legislation at the
      national and international level. According to the contemporary research,
      restraint of patients in delirium, whether it is physical restraint or
      application of psychoactive drugs, has a number of potentially harmful side
      effects and must be used with clear indications, under strict supervision, and
      with meticulously kept medical records. A delirious patient must be treated in
      accordance with medical ethics, international conventions and the laws and
      regulations related to patient rights. This includes the general principles of
      respecting the patient's autonomy and dignity, giving him or her timely
      information, notification of informed consent, as well as abiding by the rules of
      the profession integrated in every hospital written instructions on the treatment
      of a patient in delirium. A detailed medicolegal frame of restraint use in
      delirious patients is given by the Croatian Hospital Accreditation Rules, which
      is currently the highest existing standard for restraint use in delirious
      patients in ICU, as well as in the other hospital departments.
FAU - Sklebar, Ivan
AU  - Sklebar I
AD  - Sveti Duh University Hospital, Zagreb, Croatia. isklebar@kbsd.hr
FAU - Brozovic, Gordana
AU  - Brozovic G
FAU - Sklebar, Duska
AU  - Sklebar D
LA  - hrv
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Medikolegalne dileme primjene ogranicavanja delirantnih bolesnika u jedinici
      intenzivnog lijecenja.
PL  - Croatia
TA  - Acta Med Croatica
JT  - Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti
JID - 9208249
RN  - 0 (Psychotropic Drugs)
SB  - IM
MH  - Croatia
MH  - Delirium/*therapy
MH  - Humans
MH  - *Intensive Care Units
MH  - Psychotropic Drugs/*therapeutic use
MH  - Restraint, Physical/*legislation & jurisprudence
EDAT- 2012/10/24 06:00
MHDA- 2012/11/07 06:00
CRDT- 2012/10/24 06:00
PHST- 2012/10/24 06:00 [entrez]
PHST- 2012/10/24 06:00 [pubmed]
PHST- 2012/11/07 06:00 [medline]
PST - ppublish
SO  - Acta Med Croatica. 2012 Mar;66(1):11-6.


PMID- 23087734
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121023
LR  - 20211021
IS  - 2008-0255 (Electronic)
IS  - 1735-3327 (Linking)
VI  - 9
IP  - 3
DP  - 2012 May
TI  - Is there an association between early childhood caries and serum iron and serum
      ferritin levels?
PG  - 294-8
AB  - BACKGROUND: Early childhood caries (ECC) is a virulent form of dental caries that
      can destroy the primary dentition of preschool children. The purpose of this
      study was to investigate a possible association between ECC with serum iron and
      serum ferritin levels. MATERIALS AND METHODS: Following the ethical approval, 204
      children aged 24-71 months were recruited for a double-blind, randomized
      cross-sectional study. Each child was examined clinically for dental caries using
      the World Health Organization criteria in Rafsanjan, Iran. Decayed, extracted,
      and filled primary teeth (deft) index was used to measure the dental caries. To
      determine serum iron and serum ferritin levels 2 mL blood was collected from each
      child. Data were then analyzed by Pearson's correlation coefficient and t-test
      using SPSS-16.0 software. RESULTS: The mean values and their standard deviations 
      of the deft index and levels of serum iron and ferritin were 2.4(+/- 3.3),
      93.8(+/- 29.0) mug/dL and 63.1(+/- 32.2) ng/mL, respectively, with the two latter
      within. There was no significant difference between genders. Pearson's
      correlation coefficient showed that there was a statistically significant inverse
      association between ECC and serum iron level (P<0.05); but no association was
      found with the serum ferritin level. CONCLUSION: The deft index decreased
      significantly with increasing serum iron levels, but there was no association
      between ECC experience and serum ferritin levels.
FAU - Sadeghi, Mostafa
AU  - Sadeghi M
AD  - Department of Restorative Dentistry, Dental School, Rafsanjan University of
      Medical Sciences, Rafsanjan, Iran.
FAU - Darakhshan, Reza
AU  - Darakhshan R
FAU - Bagherian, Ali
AU  - Bagherian A
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Dent Res J (Isfahan)
JT  - Dental research journal
JID - 101471186
PMC - PMC3469895
OTO - NOTNLM
OT  - Deft index
OT  - early childhood caries
OT  - serum ferritin
OT  - serum iron
EDAT- 2012/10/23 06:00
MHDA- 2012/10/23 06:01
CRDT- 2012/10/23 06:00
PHST- 2012/10/23 06:00 [entrez]
PHST- 2012/10/23 06:00 [pubmed]
PHST- 2012/10/23 06:01 [medline]
PST - ppublish
SO  - Dent Res J (Isfahan). 2012 May;9(3):294-8.


PMID- 23087336
OWN - NLM
STAT- MEDLINE
DCOM- 20130318
LR  - 20121022
IS  - 1552-7409 (Electronic)
IS  - 0894-3184 (Linking)
VI  - 25
IP  - 4
DP  - 2012 Oct
TI  - Ethical implications and interprofessional education.
PG  - 313-5
LID - 10.1177/0894318412457066 [doi]
AB  - Policy and position statements from global regulatory agencies in all health
      disciplines are emphasizing and implementing requirements that interprofessional 
      team education become a mandatory educational component for each of the health
      disciplines. What is interprofessional and/or interdisciplinary team-based
      healthcare? What are potential ethical implications specifically for the practice
      of nursing? In this column the author offers an exploration of potential
      definitions and meanings for future nursing education, research, and practice
      from a nursing theoretical perspective.
FAU - Milton, Constance L
AU  - Milton CL
AD  - The Master's College, Santa Clarita, CA, USA. constancemilton@yahoo.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Nurs Sci Q
JT  - Nursing science quarterly
JID - 8805022
MH  - *Education, Professional
MH  - *Ethics
MH  - *Interprofessional Relations
EDAT- 2012/10/23 06:00
MHDA- 2013/03/19 06:00
CRDT- 2012/10/23 06:00
PHST- 2012/10/23 06:00 [entrez]
PHST- 2012/10/23 06:00 [pubmed]
PHST- 2013/03/19 06:00 [medline]
AID - 25/4/313 [pii]
AID - 10.1177/0894318412457066 [doi]
PST - ppublish
SO  - Nurs Sci Q. 2012 Oct;25(4):313-5. doi: 10.1177/0894318412457066.


PMID- 23087186
OWN - NLM
STAT- MEDLINE
DCOM- 20141020
LR  - 20181202
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 40
IP  - 3
DP  - 2014 Mar
TI  - Commentary by Janet Radcliffe-Richards on Simon Rippon's 'Imposing options on
      people in poverty: the harm of a live donor organ market'.
PG  - 152-3
LID - 10.1136/medethics-2012-100645 [doi]
FAU - Radcliffe-Richards, Janet
AU  - Radcliffe-Richards J
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20121019
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
CON - J Med Ethics. 2014 Mar;40(3):145-50. PMID: 22745109
CIN - J Med Ethics. 2014 Mar;40(3):155-6. PMID: 23129816
MH  - Commerce/*ethics
MH  - *Decision Making
MH  - Humans
MH  - *Living Donors
MH  - Paternalism/*ethics
MH  - *Personal Autonomy
MH  - *Poverty
MH  - *Social Justice
MH  - Tissue and Organ Procurement/*ethics
MH  - *Vulnerable Populations
OTO - NOTNLM
OT  - Applied and Professional Ethics
OT  - Autonomy
OT  - Donation/Procurement of Organs/Tissues
OT  - Philosophical Ethics
OT  - Regulation
EDAT- 2012/10/23 06:00
MHDA- 2014/10/21 06:00
CRDT- 2012/10/23 06:00
PHST- 2012/10/23 06:00 [entrez]
PHST- 2012/10/23 06:00 [pubmed]
PHST- 2014/10/21 06:00 [medline]
AID - medethics-2012-100645 [pii]
AID - 10.1136/medethics-2012-100645 [doi]
PST - ppublish
SO  - J Med Ethics. 2014 Mar;40(3):152-3. doi: 10.1136/medethics-2012-100645. Epub 2012
      Oct 19.


PMID- 23087185
OWN - NLM
STAT- MEDLINE
DCOM- 20130304
LR  - 20161125
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 1
DP  - 2013 Jan
TI  - The NHS and market forces in healthcare: the need for organisational ethics.
PG  - 17-21
LID - 10.1136/medethics-2012-100713 [doi]
AB  - The NHS in England is an organisation undergoing substantial change. The passage 
      of the Health and Social Care Act 2012, consolidates and builds on previous
      health policies and introduces further 'market-style' reforms of the NHS. One of 
      the main aspects of these reforms is to encourage private and third sector
      providers to deliver NHS services. The rationale for this is to foster a more
      competitive market in healthcare to encourage greater efficiency and innovation. 
      This changing healthcare environment in the English NHS sharpens the need for
      attention to be paid to the ethical operation of healthcare organisations. All
      healthcare organisations need to consider the ethical aspects of their operation,
      whether state or privately run. However, the changes in the type of organisations
      used to provide healthcare (such as commercial companies) can create new
      relationships and ethical tensions. This paper will chart the development of
      organisational ethics as a concern in applied ethics and how it arose in the USA 
      largely owing to changes in the organisation of healthcare financing and
      provision. It will be argued that an analogous transition is happening in the NHS
      in England. The paper will conclude with suggestions for the development of
      organisational ethics programmes to address some of the possible ethical issues
      raised by this new healthcare environment that incorporates both private and
      public sector providers.
FAU - Frith, Lucy
AU  - Frith L
AD  - Health Services Research, University of Liverpool, Liverpool, UK.
      L.J.Frith@liverpool.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20121019
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Delivery of Health Care/*ethics/standards/trends
MH  - England
MH  - *Ethics, Institutional
MH  - Health Care Reform/economics/ethics
MH  - Health Care Sector/economics/*ethics
MH  - Healthcare Financing/ethics
MH  - Humans
MH  - Marketing of Health Services/economics/*ethics
MH  - Organizational Innovation
MH  - Public Policy
MH  - Quality of Health Care/*ethics/standards/trends
MH  - State Medicine/economics/*ethics/organization & administration
MH  - United Kingdom
EDAT- 2012/10/23 06:00
MHDA- 2013/03/05 06:00
CRDT- 2012/10/23 06:00
PHST- 2012/10/23 06:00 [entrez]
PHST- 2012/10/23 06:00 [pubmed]
PHST- 2013/03/05 06:00 [medline]
AID - medethics-2012-100713 [pii]
AID - 10.1136/medethics-2012-100713 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Jan;39(1):17-21. doi: 10.1136/medethics-2012-100713. Epub 2012
      Oct 19.


PMID- 23086407
OWN - NLM
STAT- MEDLINE
DCOM- 20130515
LR  - 20151119
IS  - 1538-6724 (Electronic)
IS  - 0031-9023 (Linking)
VI  - 93
IP  - 3
DP  - 2013 Mar
TI  - Physical activity in students of the Medical University of Silesia in Poland.
PG  - 384-92
LID - 10.2522/ptj.20120065 [doi]
AB  - BACKGROUND: Medical students and other health care professionals have substantial
      knowledge of the benefits of regular physical activity. Furthermore, as they have
      an ethical obligation to prescribe suitable exercises, they can influence their
      patients' attitude toward physical activity and can become role models for their 
      patients. Physical therapists, who are primary care practitioners, have great
      potential for promoting physical activity; however, their role is still
      underestimated by patients and health care professionals. OBJECTIVE: The
      objectives of this study were to evaluate physical activity level in students of 
      the Medical University of Silesia in Poland and to focus on the role of physical 
      therapist students in promoting physical activity. DESIGN: This was a
      cross-sectional study. METHODS: The final analysis included 300 students from the
      schools of physical therapy, midwifery, nursing, pharmacy, cosmetology, and
      medicine at the Medical University of Silesia. The short form of the
      International Physical Activity Questionnaire (IPAQ) was used to evaluate
      physical activity level. RESULTS: Physical therapist students demonstrated the
      highest level of physical activity, with 46% demonstrating a high level of
      physical activity, 54% a moderate level of physical activity, and none a low
      level of physical activity. The largest group of students with a low level of
      physical activity comprised students from the school of medicine (26%).
      LIMITATIONS: The number of respondents was relatively small. The main study
      limitations included its cross-sectional nature and the possibility of
      self-report biases. Further research is warranted to expand the study nationally 
      and determine which factors influence physical activity. CONCLUSIONS: There was a
      large group of medical students who, despite being aware of benefits of physical 
      activity, did not meet the recommended level of physical activity. Physical
      therapist students are well trained and qualified to promote healthy habits and
      encourage individuals to undertake regular physical activity.
FAU - Dabrowska-Galas, Magdalena
AU  - Dabrowska-Galas M
AD  - Department of Sports Medicine and Physiology of Physical Effort, Medical
      University of Silesia, 12 Medykow St, 40-752 Katowice, Poland.
      mdabrowska-galas@sum.edu.pl
FAU - Plinta, Ryszard
AU  - Plinta R
FAU - Dabrowska, Jolanta
AU  - Dabrowska J
FAU - Skrzypulec-Plinta, Violetta
AU  - Skrzypulec-Plinta V
LA  - eng
PT  - Journal Article
DEP - 20121019
PL  - United States
TA  - Phys Ther
JT  - Physical therapy
JID - 0022623
SB  - IM
MH  - Cross-Sectional Studies
MH  - Female
MH  - *Health Promotion
MH  - Humans
MH  - Male
MH  - *Motor Activity
MH  - Poland
MH  - Statistics, Nonparametric
MH  - *Students, Health Occupations
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2012/10/23 06:00
MHDA- 2013/05/17 06:00
CRDT- 2012/10/23 06:00
PHST- 2012/10/23 06:00 [entrez]
PHST- 2012/10/23 06:00 [pubmed]
PHST- 2013/05/17 06:00 [medline]
AID - ptj.20120065 [pii]
AID - 10.2522/ptj.20120065 [doi]
PST - ppublish
SO  - Phys Ther. 2013 Mar;93(3):384-92. doi: 10.2522/ptj.20120065. Epub 2012 Oct 19.


PMID- 23086065
OWN - NLM
STAT- MEDLINE
DCOM- 20130114
LR  - 20130619
IS  - 1538-9855 (Electronic)
IS  - 0363-3624 (Linking)
VI  - 37
IP  - 6
DP  - 2012 Nov-Dec
TI  - Ethical reasoning and online social media.
PG  - 242-7
LID - 10.1097/NNE.0b013e31826f2c04 [doi]
AB  - Undergraduate nursing students are frequent users of social media sites; however,
      the ethical or professional implications surrounding the use of online social
      networking sites are ambiguous and understudied. Faculty guidance is needed if
      students are to gain the necessary skills and values to appropriately use social 
      media while maintaining professional accountability. The authors discuss the
      outcomes of a study that assessed their students' sensitivity to posting clinical
      information on social media sites.
FAU - Englund, Heather
AU  - Englund H
AD  - College of Nursing, University of Wisconsin Oshkosh, 54901, USA.
      englundh@uwosh.edu
FAU - Chappy, Sharon
AU  - Chappy S
FAU - Jambunathan, Jaya
AU  - Jambunathan J
FAU - Gohdes, Erick
AU  - Gohdes E
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Nurse Educ
JT  - Nurse educator
JID - 7701902
MH  - Education, Nursing, Baccalaureate
MH  - *Ethics, Nursing
MH  - Female
MH  - Humans
MH  - Male
MH  - Nursing Education Research
MH  - Nursing Evaluation Research
MH  - *Social Media
MH  - Social Networking
MH  - Students, Nursing/*psychology
MH  - *Thinking
MH  - Young Adult
EDAT- 2012/10/23 06:00
MHDA- 2013/01/15 06:00
CRDT- 2012/10/23 06:00
PHST- 2012/10/23 06:00 [entrez]
PHST- 2012/10/23 06:00 [pubmed]
PHST- 2013/01/15 06:00 [medline]
AID - 10.1097/NNE.0b013e31826f2c04 [doi]
AID - 00006223-201211000-00010 [pii]
PST - ppublish
SO  - Nurse Educ. 2012 Nov-Dec;37(6):242-7. doi: 10.1097/NNE.0b013e31826f2c04.


PMID- 23086050
OWN - NLM
STAT- MEDLINE
DCOM- 20130204
LR  - 20191210
IS  - 1556-2654 (Electronic)
IS  - 1556-2646 (Linking)
VI  - 7
IP  - 4
DP  - 2012 Oct
TI  - An investigation of case-based instructional strategies on learning, retention,
      and ethical decision-making.
PG  - 79-86
LID - 10.1525/jer.2012.7.4.79 [doi]
AB  - Case-based instruction has been successfully employed by educators across various
      fields; however, little is known about how individuals work with cases during the
      learning process. We examined two well-established instructional strategies:
      elaboration and self-development of narratives. Participants were randomly
      assigned to (1) elaborate on a given case, (2) develop their own case, (3)
      elaborate on a self-developed case, or (4) a control condition. Findings
      indicated that those who elaborated on a given case and the control group
      outperformed the other treatment groups in terms of case-based knowledge
      acquisition, execution of sensemaking processes, utilization of ethical
      decision-making (EDM) strategies, and performance on two EDM measures.
      Implications for use of instructional strategies in ethics training programs are 
      discussed.
FAU - Bagdasarov, Zhanna
AU  - Bagdasarov Z
AD  - Department of Psychology, University of Oklahoma, Norman, OK 73019, USA.
      zhannab@ou.edu
FAU - Harkrider, Lauren N
AU  - Harkrider LN
FAU - Johnson, James F
AU  - Johnson JF
FAU - MacDougall, Alexandra E
AU  - MacDougall AE
FAU - Devenport, Lynn D
AU  - Devenport LD
FAU - Connelly, Shane
AU  - Connelly S
FAU - Mumford, Michael D
AU  - Mumford MD
FAU - Peacock, Juandre
AU  - Peacock J
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Achievement
MH  - Adolescent
MH  - Adult
MH  - *Curriculum
MH  - Decision Making/*ethics
MH  - Educational Measurement
MH  - Female
MH  - Humans
MH  - *Learning
MH  - Male
MH  - *Retention, Psychology
MH  - Teaching/*methods
MH  - Young Adult
EDAT- 2012/10/23 06:00
MHDA- 2013/02/05 06:00
CRDT- 2012/10/23 06:00
PHST- 2012/10/23 06:00 [entrez]
PHST- 2012/10/23 06:00 [pubmed]
PHST- 2013/02/05 06:00 [medline]
AID - 10.1525/jer.2012.7.4.79 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2012 Oct;7(4):79-86. doi: 10.1525/jer.2012.7.4.79.


PMID- 23086047
OWN - NLM
STAT- MEDLINE
DCOM- 20130204
LR  - 20220331
IS  - 1556-2654 (Electronic)
IS  - 1556-2646 (Linking)
VI  - 7
IP  - 4
DP  - 2012 Oct
TI  - Community perspectives on research consent involving vulnerable children in
      Western Kenya.
PG  - 44-55
LID - 10.1525/jer.2012.7.4.44 [doi]
AB  - Involving vulnerable pediatric populations in international research requires
      culturally appropriate ethical protections. We sought to use mabaraza,
      traditional East African community assemblies, to understand how a community in
      western Kenya viewed participation of children in health research and informed
      consent and assent processes. Results from 108 participants revealed generally
      positive attitudes towards involving vulnerable children in research, largely
      because they assumed children would directly benefit. Consent from parents or
      guardians was understood as necessary for participation while gaining child
      assent was not. They felt other caregivers, community leaders, and even community
      assemblies could participate in the consent process. Community members believed
      research involving orphans and street children could benefit these vulnerable
      populations, but would require special processes for consent.
FAU - Vreeman, Rachel
AU  - Vreeman R
AD  - Indiana University, 107 S. Indiana Ave., Bloomington, IN 47405-7000, USA.
      rvreeman@iupui.edu
FAU - Kamaara, Eunice
AU  - Kamaara E
FAU - Kamanda, Allan
AU  - Kamanda A
FAU - Ayuku, David
AU  - Ayuku D
FAU - Nyandiko, Winstone
AU  - Nyandiko W
FAU - Atwoli, Lukoye
AU  - Atwoli L
FAU - Ayaya, Samuel
AU  - Ayaya S
FAU - Gisore, Peter
AU  - Gisore P
FAU - Scanlon, Michael
AU  - Scanlon M
FAU - Braitstein, Paula
AU  - Braitstein P
LA  - eng
GR  - K23 MH087225/MH/NIMH NIH HHS/United States
GR  - R01 HD060478/HD/NICHD NIH HHS/United States
GR  - 1K23MH087225-01./MH/NIMH NIH HHS/United States
GR  - 1R01HD060478-01A1/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Attitude
MH  - Caregivers
MH  - Child
MH  - Child, Orphaned
MH  - *Community Participation
MH  - Cultural Competency
MH  - Culture
MH  - *Ethics, Research
MH  - Female
MH  - Homeless Youth
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Internationality
MH  - Kenya
MH  - Leadership
MH  - Male
MH  - Parents
MH  - Personal Autonomy
MH  - *Residence Characteristics
MH  - *Vulnerable Populations
PMC - PMC3771107
MID - NIHMS457870
EDAT- 2012/10/23 06:00
MHDA- 2013/02/05 06:00
CRDT- 2012/10/23 06:00
PHST- 2012/10/23 06:00 [entrez]
PHST- 2012/10/23 06:00 [pubmed]
PHST- 2013/02/05 06:00 [medline]
AID - 10.1525/jer.2012.7.4.44 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2012 Oct;7(4):44-55. doi: 10.1525/jer.2012.7.4.44.


PMID- 23086046
OWN - NLM
STAT- MEDLINE
DCOM- 20130204
LR  - 20191210
IS  - 1556-2654 (Electronic)
IS  - 1556-2646 (Linking)
VI  - 7
IP  - 4
DP  - 2012 Oct
TI  - Photovoice as a community-based participatory research method among women living 
      with HIV/AIDS: ethical opportunities and challenges.
PG  - 34-43
LID - 10.1525/jer.2012.7.4.34 [doi]
AB  - Photovoice is a method in which participants use photography to identify,
      express, and disseminate their experiences. We conducted photovoice projects with
      women living with HIV/AIDS (N=21) to explore opportunities and challenges
      associated with the method. Photovoice provided a means to achieve two key
      principles of ethical public health practice: It gives participants opportunities
      to define their health priorities, and facilitates participant empowerment.
      Ethical challenges that were encountered related to exposing, through
      photographs, one's identity as living with HIV/AIDS, illicit activities, and
      other people. We discuss lessons learned for future practice to maximize the
      ethical opportunities and manage the challenges associated with using photovoice 
      as an HIV-related CBPR strategy.
FAU - Teti, Michelle
AU  - Teti M
AD  - SHP/Health Sciences, University of Missouri, Columbia, MO 65211, USA.
      tetim@health.missouri.edu
FAU - Murray, Cynthia
AU  - Murray C
FAU - Johnson, LaShaune
AU  - Johnson L
FAU - Binson, Diane
AU  - Binson D
LA  - eng
GR  - 5R25MH067127/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Acquired Immunodeficiency Syndrome
MH  - Adult
MH  - *Attitude to Health
MH  - Community-Based Participatory Research/*ethics/methods
MH  - Confidentiality/*ethics
MH  - Disclosure/ethics
MH  - *Ethics, Research
MH  - Female
MH  - HIV
MH  - *HIV Infections
MH  - Humans
MH  - Middle Aged
MH  - Photography/*ethics/methods
MH  - *Power, Psychological
MH  - Research
MH  - Social Values
MH  - Women
MH  - Young Adult
EDAT- 2012/10/23 06:00
MHDA- 2013/02/05 06:00
CRDT- 2012/10/23 06:00
PHST- 2012/10/23 06:00 [entrez]
PHST- 2012/10/23 06:00 [pubmed]
PHST- 2013/02/05 06:00 [medline]
AID - 10.1525/jer.2012.7.4.34 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2012 Oct;7(4):34-43. doi: 10.1525/jer.2012.7.4.34.


PMID- 23086045
OWN - NLM
STAT- MEDLINE
DCOM- 20130204
LR  - 20151119
IS  - 1556-2654 (Electronic)
IS  - 1556-2646 (Linking)
VI  - 7
IP  - 4
DP  - 2012 Oct
TI  - Navigating risks and professional roles: research with lesbian, gay, bisexual,
      trans, and queer young people with intellectual disabilities.
PG  - 20-33
LID - 10.1525/jer.2012.7.4.20 [doi]
AB  - We examine ethical issues that emerged during a community-based participatory
      research (CBPR) study in Toronto, Canada, exploring sexual health attitudes and
      practices among lesbian, gay, bisexual, trans, queer, and questioning (LGBTQ)
      young people (ages 17-26) labeled with intellectual disabilities. These ethical
      concerns included: (1) managing the risk of coercion, (2) consent to participate 
      in the study, (3) issues of confidentiality and disclosure, (4) balancing
      beneficence with self-determination, and (5) role conflict for
      researcher-practitioners who participate in CBPR projects. Incorporating critical
      disability perspectives and a heightened awareness of professional role conflict 
      into CBPR practices has the potential to foster development of more inclusive and
      accessible sexual health initiatives and research environments.
FAU - Marshall, Zack
AU  - Marshall Z
AD  - Memorial University of Newfoundland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Attitude to Health
MH  - *Bisexuality
MH  - Coercion
MH  - Community-Based Participatory Research/ethics
MH  - Confidentiality/ethics
MH  - Disabled Persons
MH  - Disclosure/ethics
MH  - *Ethics, Research
MH  - Female
MH  - Health Personnel
MH  - *Homosexuality
MH  - Humans
MH  - Informed Consent/ethics
MH  - *Intellectual Disability
MH  - Male
MH  - Ontario
MH  - Personal Autonomy
MH  - *Professional Role
MH  - Research Personnel
MH  - Risk
MH  - Sexual Behavior
MH  - *Transgender Persons
MH  - Young Adult
EDAT- 2012/10/23 06:00
MHDA- 2013/02/05 06:00
CRDT- 2012/10/23 06:00
PHST- 2012/10/23 06:00 [entrez]
PHST- 2012/10/23 06:00 [pubmed]
PHST- 2013/02/05 06:00 [medline]
AID - 10.1525/jer.2012.7.4.20 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2012 Oct;7(4):20-33. doi: 10.1525/jer.2012.7.4.20.


PMID- 23086044
OWN - NLM
STAT- MEDLINE
DCOM- 20130204
LR  - 20211203
IS  - 1556-2654 (Electronic)
IS  - 1556-2646 (Linking)
VI  - 7
IP  - 4
DP  - 2012 Oct
TI  - Opportunities, ethical challenges, and lessons learned from working with peer
      research assistants in a multi-method HIV community-based research study in
      Ontario, Canada.
PG  - 10-9
LID - 10.1525/jer.2012.7.4.10 [doi]
AB  - We discuss ethical challenges and opportunities experienced by peer research
      assistants (PRAs) in a multi-method HIV community-based research study in
      Ontario, Canada. We review lessons learned and best practices based on our
      experience conducting a qualitative investigation of research priorities with
      diverse women living with HIV (WLWH) and implementation of a cross-sectional
      survey with African, Caribbean, and Black WLWH. While some opportunities were
      similar across research phases for PRAs (e.g., skill building), distinct
      challenges emerged in qualitative and quantitative phases. For example, our
      training did not adequately prepare PRAs with focus group facilitation skills; at
      times, survey implementation became counseling sessions. Researchers should
      assess how best to support PRAs as part of multi-method research processes.
FAU - Logie, Carmen
AU  - Logie C
AD  - University of Calgary, Calgary, Alberta, Canada. clogie@ucalgary.ca
FAU - James, Llana
AU  - James L
FAU - Tharao, Wangari
AU  - Tharao W
FAU - Loutfy, Mona R
AU  - Loutfy MR
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Blacks
MH  - Caribbean Region
MH  - *Community-Based Participatory Research/ethics
MH  - Counseling
MH  - Cross-Sectional Studies
MH  - *Ethics, Research
MH  - Female
MH  - Focus Groups
MH  - *HIV Infections
MH  - Humans
MH  - Ontario
MH  - *Peer Group
MH  - Practice Guidelines as Topic
MH  - Qualitative Research
MH  - *Research
MH  - *Research Design
MH  - *Research Personnel/ethics
EDAT- 2012/10/23 06:00
MHDA- 2013/02/05 06:00
CRDT- 2012/10/23 06:00
PHST- 2012/10/23 06:00 [entrez]
PHST- 2012/10/23 06:00 [pubmed]
PHST- 2013/02/05 06:00 [medline]
AID - 10.1525/jer.2012.7.4.10 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2012 Oct;7(4):10-9. doi: 10.1525/jer.2012.7.4.10.


PMID- 23085048
OWN - NLM
STAT- MEDLINE
DCOM- 20131118
LR  - 20121116
IS  - 1769-6682 (Electronic)
IS  - 1297-9589 (Linking)
VI  - 40
IP  - 11
DP  - 2012 Nov
TI  - [Preimplantation genetic diagnosis--developments to expect?].
PG  - 675-8
LID - 10.1016/j.gyobfe.2012.09.009 [doi]
LID - S1297-9589(12)00262-7 [pii]
AB  - Preimplantation genetic diagnosis (PGD) has been practiced for over 20 years. It 
      prevents the birth of children with serious genetic diseases by selecting healthy
      embryos before pregnancy. In France, the initial indications of PGD have been
      extended in two directions: on the one hand, to allow identification of a
      mutation combined with embryo's HLA typing, to obtain, at birth, stem cells for
      therapeutic purposes, and on the other hand, to avoid transmission of late onset 
      diseases without having to test the at-risk parent. Other applications are
      practiced worldwide but are not allowed in our country, such as social sexing.
      Technological developments can enable more complex diagnosis, research of several
      diseases or other genetic traits. It may be useful, for example, to use this
      possibility to add screening for Down's syndrome at any PDG in older women, when 
      the risk is high. Other objectives were considered but presenting difficulties in
      their application, not only for regulatory and technical reasons, but also from
      an ethical point of view.
CI  - Copyright (c) 2012 Elsevier Masson SAS. All rights reserved.
FAU - Gosset, P
AU  - Gosset P
AD  - Laboratoire de biologie de la reproduction, unite de diagnostic preimplantatoire,
      CMCO, 19, rue Louis-Pasteur, 67303 Schiltigheim cedex, France.
      philippe.gosset@chru-strasbourg.fr
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Diagnostic preimplantatoire: des evolutions a prevoir?
DEP - 20121022
PL  - France
TA  - Gynecol Obstet Fertil
JT  - Gynecologie, obstetrique & fertilite
JID - 100936305
SB  - IM
MH  - Female
MH  - Fertilization in Vitro
MH  - France
MH  - Genetic Diseases, Inborn/diagnosis
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Mutation
MH  - Preimplantation Diagnosis/ethics/*trends
MH  - Sex Preselection/ethics
EDAT- 2012/10/23 06:00
MHDA- 2013/11/19 06:00
CRDT- 2012/10/23 06:00
PHST- 2012/05/30 00:00 [received]
PHST- 2012/09/14 00:00 [accepted]
PHST- 2012/10/23 06:00 [entrez]
PHST- 2012/10/23 06:00 [pubmed]
PHST- 2013/11/19 06:00 [medline]
AID - S1297-9589(12)00262-7 [pii]
AID - 10.1016/j.gyobfe.2012.09.009 [doi]
PST - ppublish
SO  - Gynecol Obstet Fertil. 2012 Nov;40(11):675-8. doi: 10.1016/j.gyobfe.2012.09.009. 
      Epub 2012 Oct 22.


PMID- 23084738
OWN - NLM
STAT- MEDLINE
DCOM- 20131118
LR  - 20141120
IS  - 1769-6682 (Electronic)
IS  - 1297-9589 (Linking)
VI  - 40
IP  - 11
DP  - 2012 Nov
TI  - [Reproduction without a uterus? State of the art of ectogenesis].
PG  - 695-7
LID - 10.1016/j.gyobfe.2012.09.008 [doi]
LID - S1297-9589(12)00261-5 [pii]
AB  - The concept of reproduction without uterus, or ectogenesis, has long been
      considered a myth. Nowadays, however, the in vitro conception (IVF) and embryo
      culture before implantation are largely used in humans with more than 50,000 IVF 
      and ICSI procedures yearly in France, but also in ruminants where about 400,000
      bovine embryos are produced in vitro worldwide each year. In order to proceed
      with gestation, a 3D structure enabling implantation is needed. Ex-vivo
      implantation of human embryos was obtained both in a perfused ex-vivo uterus and 
      in a 3 dimensional culture of endometrial cells, but these experiments were
      stopped because of ethical concerns. The implantation of a mouse embryo in a
      similar 3D structure has been reported but did not lead to the production of a
      live pup. Another interest for an artificial uterus or placenta would be to use
      it for ex-vivo maturation of very premature fetuses. Extra-corporal membrane
      oxygenation (ECMO) was developed for many years but its use remains disappointing
      in preterm infants when compared to the important progress made with more
      classical clinical care. In any case, goat fetuses have been maintained alive up 
      to 9 days in an artificial amniotic pouch, being oxygenated via ECMO.
CI  - Copyright (c) 2012 Elsevier Masson SAS. All rights reserved.
FAU - Chavatte-Palmer, P
AU  - Chavatte-Palmer P
AD  - Inra, UMR1198 biologie du developpement et reproduction, 78350 Jouy-en-Josas,
      France. pascale.chavatte@jouy.inra.fr
FAU - Levy, R
AU  - Levy R
FAU - Boileau, P
AU  - Boileau P
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Une reproduction sans uterus? Etat des lieux de l'ectogenese.
DEP - 20121016
PL  - France
TA  - Gynecol Obstet Fertil
JT  - Gynecologie, obstetrique & fertilite
JID - 100936305
SB  - IM
MH  - Animals
MH  - Artificial Organs
MH  - Cattle
MH  - Cells, Cultured
MH  - *Ectogenesis/ethics/physiology
MH  - Embryo Culture Techniques
MH  - Embryo Implantation
MH  - Embryo Transfer
MH  - Embryonic Development
MH  - Endometrium/cytology
MH  - Female
MH  - Fertilization in Vitro
MH  - Fetal Development
MH  - France
MH  - Humans
MH  - Mice
MH  - Placenta/physiology
MH  - Pregnancy
MH  - Reproductive Techniques, Assisted
MH  - Sperm Injections, Intracytoplasmic
MH  - Uterus
EDAT- 2012/10/23 06:00
MHDA- 2013/11/19 06:00
CRDT- 2012/10/23 06:00
PHST- 2012/06/13 00:00 [received]
PHST- 2012/09/10 00:00 [accepted]
PHST- 2012/10/23 06:00 [entrez]
PHST- 2012/10/23 06:00 [pubmed]
PHST- 2013/11/19 06:00 [medline]
AID - S1297-9589(12)00261-5 [pii]
AID - 10.1016/j.gyobfe.2012.09.008 [doi]
PST - ppublish
SO  - Gynecol Obstet Fertil. 2012 Nov;40(11):695-7. doi: 10.1016/j.gyobfe.2012.09.008. 
      Epub 2012 Oct 16.


PMID- 23084607
OWN - NLM
STAT- MEDLINE
DCOM- 20130930
LR  - 20220310
IS  - 1878-0946 (Electronic)
IS  - 1744-165X (Linking)
VI  - 18
IP  - 2
DP  - 2013 Apr
TI  - Conflict resolution in end-of-life decisions in the neonatal unit.
PG  - 83-7
LID - 10.1016/j.siny.2012.09.005 [doi]
LID - S1744-165X(12)00106-0 [pii]
AB  - End-of-life decisions are always stressful for families and professionals. As the
      decades pass, ethics and the law both change, even in one society, and cannot
      always provide perfect choices for each individual patient. Conflict should
      rarely arise in the neonatal unit. High-quality communication and compassion
      should allow professionals and families to build a team approach to the care of
      their child, even when the infant is imperilled. Each unit should have structures
      in place to deal with conflict, and every senior professional must be trained in 
      conflict resolution so that the care of the family is outstanding.
CI  - Copyright (c) 2012. Published by Elsevier Ltd.
FAU - Laing, Ian A
AU  - Laing IA
AD  - Lothian Health, Simpson Centre for Reproductive Health, Edinburgh EH16 4SA, UK.
      Electronic address: ian.laing@luht.scot.nhs.uk.
LA  - eng
PT  - Journal Article
DEP - 20121018
PL  - Netherlands
TA  - Semin Fetal Neonatal Med
JT  - Seminars in fetal & neonatal medicine
JID - 101240003
SB  - IM
MH  - Decision Making/*ethics
MH  - Family
MH  - Humans
MH  - Infant
MH  - Negotiating/*methods
MH  - Professional-Family Relations/*ethics
MH  - Terminal Care/*ethics
EDAT- 2012/10/23 06:00
MHDA- 2013/10/01 06:00
CRDT- 2012/10/23 06:00
PHST- 2012/10/23 06:00 [entrez]
PHST- 2012/10/23 06:00 [pubmed]
PHST- 2013/10/01 06:00 [medline]
AID - S1744-165X(12)00106-0 [pii]
AID - 10.1016/j.siny.2012.09.005 [doi]
PST - ppublish
SO  - Semin Fetal Neonatal Med. 2013 Apr;18(2):83-7. doi: 10.1016/j.siny.2012.09.005.
      Epub 2012 Oct 18.


PMID- 23084360
OWN - NLM
STAT- MEDLINE
DCOM- 20130320
LR  - 20121130
IS  - 1873-4502 (Electronic)
IS  - 0886-3350 (Linking)
VI  - 38
IP  - 12
DP  - 2012 Dec
TI  - Incidence of acute postoperative cystoid macular edema in clinical practice.
PG  - 2108-11
LID - 10.1016/j.jcrs.2012.07.029 [doi]
LID - S0886-3350(12)01186-8 [pii]
AB  - PURPOSE: To measure the incidence of acute postoperative cystoid macular edema
      (CME) in clinical practice. SETTING: Private clinical practice, Eugene, Oregon,
      USA. DESIGN: Retrospective chart review. METHODS: The electronic medical records 
      database was searched for the charts of all patients having cataract surgery
      during a recent 5-year period. Each chart was then examined for a diagnosis of
      CME within the 3-month postoperative period. RESULTS: From March 1, 2007, through
      March 31, 2012, 2862 phacoemulsification cataract extraction and intraocular lens
      implantation procedures were performed. Of these, 3 cases (0.1%) of acute
      postoperative CME were confirmed by diagnosis within 90 days after surgery.
      CONCLUSIONS: This chart review found a 0.1% cumulative incidence of acute
      postoperative CME. Prophylaxis with topical steroidal and nonsteroidal agents may
      help reduce the incidence of CME. If the incidence of CME in this study applies
      generally, it would be harder to successfully and ethically perform a randomized 
      trial of medical prophylaxis. FINANCIAL DISCLOSURE: Dr. Packer is a consultant to
      Advanced Medical Optics, Inc., Allergan, Inc., Bausch & Lomb Surgical, Inc., and 
      Ista Pharmaceuticals, Inc. No other author has a financial or proprietary
      interest in any material or method mentioned.
CI  - Copyright (c) 2012 ASCRS and ESCRS. Published by Elsevier Inc. All rights
      reserved.
FAU - Packer, Mark
AU  - Packer M
AD  - Oregon Health and Sciences University School of Medicine, Eugene, Oregon, USA.
      mpacker@finemd.com
FAU - Lowe, Jennifer
AU  - Lowe J
FAU - Fine, Howard
AU  - Fine H
LA  - eng
PT  - Journal Article
DEP - 20121016
PL  - United States
TA  - J Cataract Refract Surg
JT  - Journal of cataract and refractive surgery
JID - 8604171
SB  - IM
MH  - Acute Disease
MH  - Fluorescein Angiography
MH  - Humans
MH  - Incidence
MH  - *Lens Implantation, Intraocular
MH  - Macular Edema/diagnosis/*epidemiology
MH  - *Phacoemulsification
MH  - *Postoperative Complications
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence
MH  - Visual Acuity/physiology
EDAT- 2012/10/23 06:00
MHDA- 2013/03/21 06:00
CRDT- 2012/10/23 06:00
PHST- 2012/06/25 00:00 [received]
PHST- 2012/07/10 00:00 [revised]
PHST- 2012/07/11 00:00 [accepted]
PHST- 2012/10/23 06:00 [entrez]
PHST- 2012/10/23 06:00 [pubmed]
PHST- 2013/03/21 06:00 [medline]
AID - S0886-3350(12)01186-8 [pii]
AID - 10.1016/j.jcrs.2012.07.029 [doi]
PST - ppublish
SO  - J Cataract Refract Surg. 2012 Dec;38(12):2108-11. doi:
      10.1016/j.jcrs.2012.07.029. Epub 2012 Oct 16.


PMID- 23084164
OWN - NLM
STAT- MEDLINE
DCOM- 20130215
LR  - 20220330
IS  - 1879-1972 (Electronic)
IS  - 1054-139X (Linking)
VI  - 51
IP  - 5
DP  - 2012 Nov
TI  - Older adolescents' views regarding participation in Facebook research.
PG  - 439-44
LID - 10.1016/j.jadohealth.2012.02.001 [doi]
LID - S1054-139X(12)00054-7 [pii]
AB  - PURPOSE: Facebook continues to grow in popularity among adolescents as well as
      adolescent researchers. Guidance on conducting research using Facebook with
      appropriate attention to privacy and ethics is scarce. To inform such research
      efforts, the purpose of this study was to determine older adolescents' responses 
      after learning that they were participants in a research study that involved
      identification of participants using Facebook. METHODS: Public Facebook profiles 
      of older adolescents aged 18-19 years from a large state university were
      examined. Profile owners were then interviewed. During the interview,
      participants were informed that they were identified by examining publicly
      available Facebook profiles. Participants were asked to discuss their views on
      this research method. RESULTS: A total of 132 participants completed the
      interview (70% response rate); the average age was 18.4 years (SD = .5); and our 
      sample included 64 male participants (48.5%). Participant responses included
      endorsement (19.7%), fine (36.4%), neutral (28.8%), uneasy (9.1%), and concerned 
      (6.1%). Among participants who were uneasy or concerned, the majority voiced
      confusion regarding their current profile security settings (p = .00).
      CONCLUSIONS: The majority of adolescent participants viewed the use of Facebook
      for research positively. These findings are consistent with the approach taken by
      many U.S. courts. Researchers may consider these findings when developing
      research protocols involving Facebook.
CI  - Copyright (c) 2012 Society for Adolescent Health and Medicine. Published by
      Elsevier Inc. All rights reserved.
FAU - Moreno, Megan A
AU  - Moreno MA
AD  - Department of Pediatrics, School of Medicine and Public Health, University of
      Wisconsin, Madison, Wisconsin 53705, USA. mamoreno@pediatrics.wisc.edu
FAU - Grant, Alison
AU  - Grant A
FAU - Kacvinsky, Lauren
AU  - Kacvinsky L
FAU - Moreno, Peter
AU  - Moreno P
FAU - Fleming, Michael
AU  - Fleming M
LA  - eng
GR  - K12 HD055894/HD/NICHD NIH HHS/United States
GR  - R03 AA019572/AA/NIAAA NIH HHS/United States
GR  - R03 AA019572-01/AA/NIAAA NIH HHS/United States
GR  - K12HD055894/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20120328
PL  - United States
TA  - J Adolesc Health
JT  - The Journal of adolescent health : official publication of the Society for
      Adolescent Medicine
JID - 9102136
SB  - IM
MH  - Adolescent
MH  - Attitude
MH  - Computer Security
MH  - Confidentiality
MH  - Data Collection/methods
MH  - Female
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - *Patient Participation
MH  - *Social Media
MH  - Young Adult
PMC - PMC3478668
MID - NIHMS355432
EDAT- 2012/10/23 06:00
MHDA- 2013/02/16 06:00
CRDT- 2012/10/23 06:00
PHST- 2011/11/01 00:00 [received]
PHST- 2012/01/29 00:00 [revised]
PHST- 2012/02/01 00:00 [accepted]
PHST- 2012/10/23 06:00 [entrez]
PHST- 2012/10/23 06:00 [pubmed]
PHST- 2013/02/16 06:00 [medline]
AID - S1054-139X(12)00054-7 [pii]
AID - 10.1016/j.jadohealth.2012.02.001 [doi]
PST - ppublish
SO  - J Adolesc Health. 2012 Nov;51(5):439-44. doi: 10.1016/j.jadohealth.2012.02.001.
      Epub 2012 Mar 28.


PMID- 23083393
OWN - NLM
STAT- MEDLINE
DCOM- 20130325
LR  - 20220311
IS  - 1365-2702 (Electronic)
IS  - 0962-1067 (Linking)
VI  - 21
IP  - 21-22
DP  - 2012 Nov
TI  - Decision-making related to complementary and alternative medicine use by people
      with Type 2 diabetes: a qualitative study.
PG  - 3205-15
LID - 10.1111/j.1365-2702.2012.04339.x [doi]
AB  - AIMS AND OBJECTIVES: To explore how complementary and alternative medicine (CAM) 
      users make decisions about CAM use. Specifically, an exploration of the processes
      used by people with Type 2 diabetes, related to the assessment of information
      sources, factors influencing decision-making and the role of other key
      individuals, was undertaken. BACKGROUND: Patients with chronic illnesses
      increasingly seek to use CAM to improve their well-being. Currently, however, the
      decision-making processes related to CAM use among people with Type 2 diabetes
      are poorly understood. METHODS: An exploratory study using a naturalistic design,
      with in-depth semi-structured interviews, was undertaken. Purposive sampling was 
      used to recruit participants with Type 2 diabetes who used CAM alongside
      conventional medicine. The data were analysed in a three-step coding process.
      Ethical approval was gained from a human research ethics committee. RESULTS:
      Evidence about CAM use from interview data was consistent with a
      multi-dimensional decision-making processes used by participants. Four major
      categories emerged: recognising the need for using CAM; assessing the potential
      CAM before use; matching CAM use to personal philosophy; and ongoing evaluation
      of CAM. CONCLUSION: As diabetes affects the entirety of a person's being
      self-management, incorporating CAMs has become a way of controlling the condition
      and improving well-being. It is important for health professionals to consider
      clients' CAM use and to incorporate this information, where appropriate, into
      management plans. RELEVANCE TO CLINICAL PRACTICE: Health care professionals
      should be aware of patients who use CAM while under conventional medical care and
      should discuss CAM use at various points in the client journey to facilitate
      better communication.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Chang, Hsiao-Yun Annie
AU  - Chang HY
AD  - School of Nursing, Fooyin University, Kaohsiung, Taiwan. chang369@gmail.com
FAU - Wallis, Marianne
AU  - Wallis M
FAU - Tiralongo, Evelin
AU  - Tiralongo E
FAU - Wang, Hui Lan
AU  - Wang HL
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Clin Nurs
JT  - Journal of clinical nursing
JID - 9207302
MH  - *Complementary Therapies
MH  - *Decision Making
MH  - Diabetes Mellitus, Type 2/*psychology/therapy
MH  - Humans
MH  - Qualitative Research
MH  - Taiwan
EDAT- 2012/10/23 06:00
MHDA- 2013/03/26 06:00
CRDT- 2012/10/23 06:00
PHST- 2012/10/23 06:00 [entrez]
PHST- 2012/10/23 06:00 [pubmed]
PHST- 2013/03/26 06:00 [medline]
AID - 10.1111/j.1365-2702.2012.04339.x [doi]
PST - ppublish
SO  - J Clin Nurs. 2012 Nov;21(21-22):3205-15. doi: 10.1111/j.1365-2702.2012.04339.x.


PMID- 23082774
OWN - NLM
STAT- MEDLINE
DCOM- 20140824
LR  - 20131217
IS  - 1365-2788 (Electronic)
IS  - 0964-2633 (Linking)
VI  - 58
IP  - 2
DP  - 2014 Feb
TI  - Sex offenders with intellectual disabilities and their academic observers:
      popular methodologies and research interests.
PG  - 189-97
LID - 10.1111/j.1365-2788.2012.01644.x [doi]
AB  - BACKGROUND: Over the past two decades, disability activists and scholars have
      developed research paradigms that aim to place (some of the) control over the
      research process in the hands of disabled people. This paper discusses the
      appropriateness of applying such paradigms to sex offenders with intellectual
      disabilities (ID). It exposes to what extent current research about this
      population is affected by these developments. METHODS: A content analysis of a
      sample of 80 articles across 20 academic journals was carried out. This recorded 
      the data collection methods used, to what extent the views of people with ID were
      represented, subject affiliations of the authors and the subject matter
      discussed. RESULTS: Few studies make sense of the personal accounts of this
      population. Social scientists have mostly not engaged in this area of research,
      which results in significant gaps in knowledge. CONCLUSIONS: We currently know
      little about the subjectivity of sex offenders with ID. Research that seeks to
      explore this may enhance our understanding of this population and thus contribute
      towards the effectiveness of preventative work and risk management.
CI  - (c) 2012 The Author. Journal of Intellectual Disability Research (c) 2012 John
      Wiley & Sons Ltd, MENCAP & IASSIDD.
FAU - Hollomotz, A
AU  - Hollomotz A
AD  - Centre for Disability Studies: School of Sociology and Social Policy, The
      University of Leeds, Leeds, UK.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20121022
PL  - England
TA  - J Intellect Disabil Res
JT  - Journal of intellectual disability research : JIDR
JID - 9206090
SB  - IM
MH  - Criminals/*psychology
MH  - Humans
MH  - Intellectual Disability/*psychology
MH  - Sex Offenses/*psychology
OTO - NOTNLM
OT  - inclusive research
OT  - learning difficulties
OT  - learning disabilities
OT  - research ethics
OT  - sex offending
OT  - sexually challenging behaviour
EDAT- 2012/10/23 06:00
MHDA- 2014/08/26 06:00
CRDT- 2012/10/23 06:00
PHST- 2012/09/15 00:00 [accepted]
PHST- 2012/10/23 06:00 [entrez]
PHST- 2012/10/23 06:00 [pubmed]
PHST- 2014/08/26 06:00 [medline]
AID - 10.1111/j.1365-2788.2012.01644.x [doi]
PST - ppublish
SO  - J Intellect Disabil Res. 2014 Feb;58(2):189-97. doi:
      10.1111/j.1365-2788.2012.01644.x. Epub 2012 Oct 22.


PMID- 23082636
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20211021
IS  - 1606-0997 (Print)
IS  - 1606-0997 (Linking)
VI  - 30
IP  - 3
DP  - 2012 Sep
TI  - Attitudes of healthcare providers towards non-initiation and withdrawal of
      neonatal resuscitation for preterm infants in Mongolia.
PG  - 346-52
AB  - Antenatal parental counselling by healthcare providers is recommended to inform
      parents and assist with decision-making before the birth of a child with
      anticipated poor prognosis. In the setting of a low-income country, like
      Mongolia, attitudes of healthcare providers towards resuscitation of high-risk
      newborns are unknown. The purpose of this study was to examine the attitudes of
      healthcare providers regarding ethical decisions pertaining to non-initiation and
      withdrawal of neonatal resuscitation in Mongolia. A questionnaire on attitudes
      towards decision-making for non-initiation and withdrawal of neonatal
      resuscitation was administered to 113 healthcare providers attending neonatal
      resuscitation training courses in 2009 in Ulaanbaatar, the capital and the
      largest city of Mongolia where -40% of deliveries in the country occur. The
      questionnaire was developed in English and translated into Mongolian and included
      multiple choices and free-text responses. Participation was voluntary, and
      anonymity of the participants was strictly maintained. In total, 113 sets of
      questionnaire were completed by Mongolian healthcare providers, including
      neonatologists, paediatricians, neonatal and obstetrical nurses, and midwives,
      with 100% response rate. Ninety-six percent of respondents were women, with 73%
      of participants from Ulaanbaatar and 27% (all midwives) from the countryside. The
      majority (96%) of healthcare providers stated they attempt pre-delivery
      counselling to discuss potential poor outcomes when mothers present with preterm 
      labour. However, most (90%) healthcare providers stated they feel uncomfortable
      discussing not initiating or withdrawing neonatal resuscitation for a baby born
      alive with little chance of survival. Religious beliefs and concerns about
      long-term pain for the baby were the most common reasons for not initiating
      neonatal resuscitation or withdrawing care for a baby born too premature or with 
      congenital birth-defects. Most Mongolian healthcare providers provide antenatal
      counselling to parents regarding neonatal resuscitation. Additional research is
      needed to determine if the above-said difficulty with counselling stems from
      deficiencies in communication training and whether these same counselling-related
      issues exist in other countries. Future educational efforts in teaching neonatal 
      resuscitation in Mongolia should incorporate culturally-sensitive training on
      antenatal counselling.
FAU - McAdams, Ryan M
AU  - McAdams RM
AD  - Department of Pediatrics, Division of Neonatology, University of Washington, Box 
      356320, Seattle, WA 98195-6320, USA. mcadams@uw.edu
FAU - Erdenebileg, Ariuntsatsral
AU  - Erdenebileg A
FAU - Batra, Maneesh
AU  - Batra M
FAU - Gerelmaa, Zagd
AU  - Gerelmaa Z
LA  - eng
PT  - Journal Article
PL  - Bangladesh
TA  - J Health Popul Nutr
JT  - Journal of health, population, and nutrition
JID - 100959228
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel/ethnology
MH  - Delivery of Health Care/ethnology
MH  - Female
MH  - Health Care Surveys
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Infant, Premature, Diseases/etiology/*therapy
MH  - Male
MH  - Mongolia
MH  - Obstetric Labor, Premature/ethnology/physiopathology
MH  - Patient Education as Topic
MH  - Poverty Areas
MH  - Pregnancy
MH  - *Resuscitation Orders
MH  - Rural Health Services
MH  - Urban Health Services
MH  - Workforce
PMC - PMC3489950
EDAT- 2012/10/23 06:00
MHDA- 2012/11/14 06:00
CRDT- 2012/10/23 06:00
PHST- 2012/10/23 06:00 [entrez]
PHST- 2012/10/23 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
AID - 10.3329/jhpn.v30i3.12298 [doi]
PST - ppublish
SO  - J Health Popul Nutr. 2012 Sep;30(3):346-52. doi: 10.3329/jhpn.v30i3.12298.


PMID- 23082030
OWN - NLM
STAT- MEDLINE
DCOM- 20140109
LR  - 20161125
IS  - 1464-3790 (Electronic)
IS  - 0967-0742 (Linking)
VI  - 21
IP  - 2
DP  - 2013 Mar
TI  - Is the HFEA's policy on compensating egg donors and egg sharers defensible?
PG  - 173-212
LID - 10.1093/medlaw/fws027 [doi]
AB  - This paper asks whether the Human Fertilisation and Embryology Authority's
      (HFEA's) recently revised policies on compensating egg donors and egg sharers are
      defensible, paying particular heed to the ethical arguments, concepts, and
      principles deployed in support of them. The paper proceeds by briefly outlining
      both the 'old' and 'new' HFEA policies before describing and explaining the main 
      arguments that are supposed to underpin these. The arguments are then subjected
      to scrutiny and generally found wanting. The paper's primary conclusion is that
      treating egg sharers more generously than egg donors (which is what both the
      'old' and 'new' policies do) is inconsistent and unjustified. In order to render 
      the HFEA's policies consistent, it would need either to limit more strictly the
      benefits-in-kind available to egg sharers or to take a more permissive approach
      to monetary compensation for egg donors. The paper's secondary conclusion is that
      the latter is preferable. Egg donors could, provided that suitable regulatory
      controls were in place, be compensated more generously without this being
      ethically problematic. Furthermore, since egg sharing is in some respects more
      problematic than other forms of egg donation, there is something to be said for
      encouraging a move away from sharing to donation.
FAU - Wilkinson, Stephen
AU  - Wilkinson S
AD  - School of Law, Keele University, Keele ST5 5BG, UK. s.wilkinson@keele.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20121018
PL  - England
TA  - Med Law Rev
JT  - Medical law review
JID - 9308945
SB  - IM
MH  - Female
MH  - Fertilization in Vitro/economics/legislation & jurisprudence
MH  - Financing, Government
MH  - *Health Policy
MH  - Humans
MH  - Oocyte Donation/*economics/ethics/*legislation & jurisprudence
MH  - United Kingdom
OTO - NOTNLM
OT  - Donation
OT  - Egg
OT  - Ethics
OT  - Gamete
OT  - HFEA
OT  - Payment
EDAT- 2012/10/20 06:00
MHDA- 2014/01/10 06:00
CRDT- 2012/10/20 06:00
PHST- 2012/10/20 06:00 [entrez]
PHST- 2012/10/20 06:00 [pubmed]
PHST- 2014/01/10 06:00 [medline]
AID - fws027 [pii]
AID - 10.1093/medlaw/fws027 [doi]
PST - ppublish
SO  - Med Law Rev. 2013 Mar;21(2):173-212. doi: 10.1093/medlaw/fws027. Epub 2012 Oct
      18.


PMID- 23081782
OWN - NLM
STAT- MEDLINE
DCOM- 20130516
LR  - 20211021
IS  - 1573-076X (Electronic)
IS  - 0165-005X (Linking)
VI  - 36
IP  - 4
DP  - 2012 Dec
TI  - The experience of addiction as told by the addicted: incorporating biological
      understandings into self-story.
PG  - 712-34
LID - 10.1007/s11013-012-9283-x [doi]
AB  - How do the addicted view addiction against the framework of formal theories that 
      attempt to explain the condition? In this empirical paper, we report on the lived
      experience of addiction based on 63 semi-structured, open-ended interviews with
      individuals in treatment for alcohol and nicotine abuse at five sites in
      Minnesota. Using qualitative analysis, we identified four themes that provide
      insights into understanding how people who are addicted view their addiction,
      with particular emphasis on the biological model. More than half of our sample
      articulated a biological understanding of addiction as a disease. Themes did not 
      cluster by addictive substance used; however, biological understandings of
      addiction did cluster by treatment center. Biological understandings have the
      potential to become dominant narratives of addiction in the current era. Though
      the desire for a "unified theory" of addiction seems curiously seductive to
      scholars, it lacks utility. Conceptual "disarray" may actually reflect a more
      accurate representation of the illness as told by those who live with it. For
      practitioners in the field of addiction, we suggest the practice of narrative
      medicine with its ethic of negative capability as a useful approach for
      interpreting and relating to diverse experiences of disease and illness.
FAU - Hammer, Rachel R
AU  - Hammer RR
AD  - Mayo Medical School, Rochester, MN 55905, USA. hammer.rachel@mayo.edu
FAU - Dingel, Molly J
AU  - Dingel MJ
FAU - Ostergren, Jenny E
AU  - Ostergren JE
FAU - Nowakowski, Katherine E
AU  - Nowakowski KE
FAU - Koenig, Barbara A
AU  - Koenig BA
LA  - eng
GR  - R01 DA014577/DA/NIDA NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Cult Med Psychiatry
JT  - Culture, medicine and psychiatry
JID - 7707467
SB  - IM
MH  - Adult
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Interview, Psychological
MH  - Male
MH  - Middle Aged
MH  - *Narration
MH  - *Self Concept
MH  - Substance-Related Disorders/*psychology
PMC - PMC3500839
MID - NIHMS416356
EDAT- 2012/10/20 06:00
MHDA- 2013/05/17 06:00
CRDT- 2012/10/20 06:00
PHST- 2012/10/20 06:00 [entrez]
PHST- 2012/10/20 06:00 [pubmed]
PHST- 2013/05/17 06:00 [medline]
AID - 10.1007/s11013-012-9283-x [doi]
PST - ppublish
SO  - Cult Med Psychiatry. 2012 Dec;36(4):712-34. doi: 10.1007/s11013-012-9283-x.


PMID- 23080355
OWN - NLM
STAT- MEDLINE
DCOM- 20130402
LR  - 20211021
IS  - 1432-055X (Electronic)
IS  - 0003-2417 (Linking)
VI  - 61
IP  - 10
DP  - 2012 Oct
TI  - [Real-time 3 dimensional full volume data set : benefits in problem focused
      intraoperative transesophageal echocardiography].
PG  - 875-82
LID - 10.1007/s00101-012-2088-z [doi]
AB  - BACKGROUND: Comprehensive intraoperative transesophageal echcardiography (TEE)
      includes various measurements for quantification of cardiac chambers and valves
      based on multiple two dimensional (2D) standard views. Due to shortness of time
      during cardiac surgery most centres in Germany only carry out problem focussed
      intraoperative examinations which does not allow the complete repertoire of
      measurements to be exhausted. The aim of this study was to investigate which
      measurements for cardiac chamber and valve quantification can be performed with
      the acquisition of a real-time 3D full volume (RT-3D-FV) data set and to compare 
      these measurements with those based on standard 2D views. MATERIALS AND METHODS: 
      In patients undergoing elective surgical mitral valve repair a comprehensive 2D
      TEE examination according to the guidelines of the American Society of
      Echocardiography (ASE) and the Society of Cardiovascular Anesthesiologists (SCA) 
      was performed after induction of anesthesia. Additionally, a RT-3D-FV TEE data
      set based on the midesophageal four chamber view was recorded (iE 33, Philips,
      Netherlands). All measurements of the 2D TEE and the RT-3D-FV dataset (Qlab) were
      performed offline by two independent examiners. RESULTS: After approval by the
      local ethic committee and obtaining written informed consent 50 patients (31 male
      and 19 female) with a mean age of 59.4 +/- 11.5 years were enrolled in this
      study. All measurements recommended for chamber and valve quantification could be
      performed on the basis of the RT-3D-FV data set except for measurements of the
      sinus of Valsalva and the sinotubular junction. There was good correlation
      between the results of the two methods. CONCLUSIONS: For intraoperative problem
      focussed TEE examinations the acquisition of an additional RT-3D-FV TEE data set 
      allows accurate measurement of most of the recommended chamber and valve
      quantification parameters.
FAU - Ender, A
AU  - Ender A
AD  - Abteilung fur Anasthesiologie und Intensivmedizin II, Herzzentrum, Universitat
      Leipzig, Strumpellstr. 39, 04289, Leipzig, Deutschland.
FAU - Eibel, S
AU  - Eibel S
FAU - Hasheminejad, E
AU  - Hasheminejad E
FAU - Scholz, M
AU  - Scholz M
FAU - Kaisers, U X
AU  - Kaisers UX
FAU - Mukherjee, C
AU  - Mukherjee C
FAU - Ender, J
AU  - Ender J
LA  - ger
PT  - Comparative Study
PT  - Journal Article
TT  - "Real-time-3-dimensional-full-volume"-datensatz : nutzen in der
      problemfokussierten intraoperativen transosophagealen echokardiographie.
DEP - 20121020
PL  - Germany
TA  - Anaesthesist
JT  - Der Anaesthesist
JID - 0370525
SB  - IM
MH  - Aged
MH  - Cardiac Surgical Procedures
MH  - Data Interpretation, Statistical
MH  - Databases, Factual
MH  - Echocardiography
MH  - Echocardiography, Three-Dimensional/*statistics & numerical data
MH  - Echocardiography, Transesophageal/*statistics & numerical data
MH  - Female
MH  - Heart Atria/surgery
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Male
MH  - Middle Aged
MH  - Mitral Valve/diagnostic imaging/surgery
MH  - Monitoring, Intraoperative/*statistics & numerical data
MH  - Real-Time Polymerase Chain Reaction
MH  - Sinus of Valsalva/diagnostic imaging
MH  - Tricuspid Valve/diagnostic imaging
EDAT- 2012/10/20 06:00
MHDA- 2013/04/03 06:00
CRDT- 2012/10/20 06:00
PHST- 2012/01/19 00:00 [received]
PHST- 2012/09/03 00:00 [accepted]
PHST- 2012/08/31 00:00 [revised]
PHST- 2012/10/20 06:00 [entrez]
PHST- 2012/10/20 06:00 [pubmed]
PHST- 2013/04/03 06:00 [medline]
AID - 10.1007/s00101-012-2088-z [doi]
PST - ppublish
SO  - Anaesthesist. 2012 Oct;61(10):875-82. doi: 10.1007/s00101-012-2088-z. Epub 2012
      Oct 20.


PMID- 23080237
OWN - NLM
STAT- MEDLINE
DCOM- 20131203
LR  - 20181202
IS  - 1538-8654 (Electronic)
IS  - 1527-7941 (Linking)
VI  - 25
IP  - 11
DP  - 2012 Nov
TI  - A randomized controlled trial to evaluate an antimicrobial dressing with silver
      alginate powder for the management of chronic wounds exhibiting signs of critical
      colonization.
PG  - 503-8
LID - 10.1097/01.ASW.0000422628.63148.4b [doi]
AB  - OBJECTIVE: The primary objective of this study was to evaluate if a topical
      silver dressing that consists of silver alginate powder is effective in managing 
      chronic wounds that exhibit signs of critical colonization and promoting wound
      healing. METHOD: This was a prospective, open-label, 4-week randomized controlled
      trial. The primary end points of the study were changes in signs associated with 
      critical colonization and in wound surface areas. All subjects were evaluated at 
      weeks 0, 2, and 4 at the end of the study. SUBJECT AND SETTINGS: Participants
      between 18 and 85 years of age were recruited from 2 wound care clinics in
      Canada. The study was reviewed and approved by research ethics boards. DATA
      ANALYSIS: Analyses of this study were carried out based on intent-to-treat
      principle; t tests were used to determine if the means were statistically
      different between treatment groups. RESULTS: Thirty-four subjects participated
      and completed in the study. In the control group, the mean infection checklist
      score was 2.2 at baseline and 2.3 at week 4 (t9 = -0.36, P = .73). In the silver 
      alginate powder group, the infection score reduced from 3.3 at baseline to 1.3 at
      week 4; the result was significant (t23 = 7.62, P < .00). The difference in
      average surface reduction over time between the 2 groups was statistically
      significant (t32 = 3.56, P < .001). Subjects randomized to the silver group
      achieved a greater surface reduction than those who were randomized to the use of
      foam dressing as the control. CONCLUSION: Silver alginate powder is an effective 
      treatment option for wounds with increased bacterial burden.
FAU - Woo, Kevin Y
AU  - Woo KY
AD  - School of Nursing, Queen's University, Kingston, and Wound Care Consultant, West 
      Park Health Centre, Toronto, Ontario, Canada.
FAU - Coutts, Patricia M
AU  - Coutts PM
FAU - Sibbald, R Gary
AU  - Sibbald RG
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Adv Skin Wound Care
JT  - Advances in skin & wound care
JID - 100911021
RN  - 0 (Alginates)
RN  - 0 (Anti-Infective Agents, Local)
RN  - 0 (Biocompatible Materials)
RN  - 0 (Hexuronic Acids)
RN  - 0 (Powders)
RN  - 0 (Silver Compounds)
RN  - 8A5D83Q4RW (Glucuronic Acid)
MH  - Adult
MH  - Aged
MH  - Alginates/*administration & dosage
MH  - Anti-Infective Agents, Local/*administration & dosage
MH  - *Bandages
MH  - Biocompatible Materials
MH  - Female
MH  - Glucuronic Acid/administration & dosage
MH  - Hexuronic Acids/administration & dosage
MH  - Humans
MH  - Leg Ulcer/microbiology/pathology/*therapy
MH  - Male
MH  - Middle Aged
MH  - Powders
MH  - Silver Compounds/*administration & dosage
MH  - Treatment Outcome
MH  - Wound Healing
MH  - Wound Infection/microbiology/pathology/*prevention & control
EDAT- 2012/10/20 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/10/20 06:00
PHST- 2012/10/20 06:00 [entrez]
PHST- 2012/10/20 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1097/01.ASW.0000422628.63148.4b [doi]
AID - 00129334-201211000-00007 [pii]
PST - ppublish
SO  - Adv Skin Wound Care. 2012 Nov;25(11):503-8. doi:
      10.1097/01.ASW.0000422628.63148.4b.


PMID- 23079868
OWN - NLM
STAT- MEDLINE
DCOM- 20140814
LR  - 20151119
IS  - 1532-3099 (Electronic)
IS  - 0266-6138 (Linking)
VI  - 29
IP  - 8
DP  - 2013 Aug
TI  - More than re-establishing the partner relationship: Intimate aftercare for Somali
      parents in diaspora.
PG  - 863-70
LID - 10.1016/j.midw.2012.09.002 [doi]
LID - S0266-6138(12)00167-2 [pii]
AB  - OBJECTIVE: to explore the sexual relationship and couples' perceptions about
      intimate partner support following childbirth. DESIGN: a hermeneutic design using
      a naturalistic inquiry framework as a qualitative proxy for medical anthropology.
      Data were collected using a fictional and culturally-specific narrative during
      focus group discussions (FGDs) in early 2011. Analysis was conducted by
      'functional narrative analysis' and interpreted for conceptual constructions.
      Recruitment was by snowball and purposive sampling. SETTING: a diasporic context 
      among participants living in six urban centres across Sweden. PARTICIPANTS:
      successful recruitment included 16 Somali-Swedish fathers and 27 mothers. Three
      FDGs were conducted with fathers (3-7 participants) and seven with mothers (3-6
      participants). FINDINGS: within day 40 post partum, parents learn to rely on each
      other in the absence of traditional support networks. After the first 40 days,
      the re-introduction of sexual intimacy is likely to occur. Of the fathers
      experiencing postpartum sexual aversion, these seemed to experience 'existential 
      angst' resulting from a combination of profound remorse over having put the
      partner into what they perceived as a life-threatening situation during
      childbirth and their perceived moral and ethical obligations to provide support
      in this setting. Mothers in general did not directly discuss their own sexuality.
      Women could imagine men's sexual aversion after witnessing childbirth. However,
      they seemed unaware of men's potential for angst. Mothers are situated between
      the loss of traditional postpartum support networks, comprised of close female
      kin, and their own newly-defined responsibilities in the host setting. Fathers
      embrace their new role. Both partners articulated the mother's new role as
      enhancing autonomy and independence in the host setting. However, women held
      mixed attitudes about fathers replacing traditional kin support. IMPLICATIONS FOR
      PRACTICE: to date, late postpartum aftercare for immigrant African parents is
      anecdotally linked to evidence-based recommendations, which have been identified 
      for parents who are ethnically-congruent to a western study setting. Our findings
      suggest that aftercare meant for Somali parents living in these settings requires
      an understanding of how traditional intimate support and the postpartum sexual
      relationship are re-negotiated in the diasporic context. This includes
      recognition of the father as a willing and supportive partner.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Binder, Pauline
AU  - Binder P
AD  - Department of Women's and Children's Health, Uppsala University Hospital,
      Uppsala, Sweden. pauline.binder@kbh.uu.se
FAU - Johnsdotter, Sara
AU  - Johnsdotter S
FAU - Essen, Birgitta
AU  - Essen B
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20121016
PL  - Scotland
TA  - Midwifery
JT  - Midwifery
JID - 8510930
MH  - Adult
MH  - Aftercare/*psychology
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Interpersonal Relations
MH  - Male
MH  - Parents/*psychology
MH  - Parturition/psychology
MH  - Postpartum Period/psychology
MH  - Sexual Behavior/*psychology
MH  - Sexual Partners/*psychology
MH  - Somalia
MH  - Surveys and Questionnaires
MH  - Sweden
OTO - NOTNLM
OT  - Midwifery guidelines
OT  - Postpartum sexual aversion
OT  - Proxy for anthropology
EDAT- 2012/10/20 06:00
MHDA- 2014/08/15 06:00
CRDT- 2012/10/20 06:00
PHST- 2012/04/25 00:00 [received]
PHST- 2012/08/16 00:00 [revised]
PHST- 2012/09/03 00:00 [accepted]
PHST- 2012/10/20 06:00 [entrez]
PHST- 2012/10/20 06:00 [pubmed]
PHST- 2014/08/15 06:00 [medline]
AID - S0266-6138(12)00167-2 [pii]
AID - 10.1016/j.midw.2012.09.002 [doi]
PST - ppublish
SO  - Midwifery. 2013 Aug;29(8):863-70. doi: 10.1016/j.midw.2012.09.002. Epub 2012 Oct 
      16.


PMID- 23079580
OWN - NLM
STAT- MEDLINE
DCOM- 20140303
LR  - 20130618
IS  - 1461-7196 (Electronic)
IS  - 1363-4593 (Linking)
VI  - 17
IP  - 4
DP  - 2013 Jul
TI  - 'Catching up': The significance of occupational communities for the delivery of
      high quality home care by community nurses.
PG  - 422-38
LID - 10.1177/1363459312460703 [doi]
AB  - This article examines the importance of some informal work practices among
      community nurses during a period of significant organizational change.
      Ethnographic fieldwork in two purposively selected adult community nursing
      services in England comprised 79 hours of observation of routine practice, 21
      interviews with staff and 23 interviews with patients. We identified the informal
      work practice of 'catching up', informal work conversations between immediate
      colleagues, as an important but often invisible aspect of satisfying work
      relationships and of the relational care of patients. Drawing on anthropological 
      literatures on 'communities of practice' the article examines two central issues 
      concerning the practices of 'catching up': (1) how informal learning processes
      shape community nursing work; (2) how this informal learning is shaped both in
      relation to the ideals of community nursing work and the wider political and
      organizational contexts of community nursing practice. Our findings highlight the
      distinctive value of informal workplace 'catch ups' for nurses to manage the
      inherent challenges of good home care for patients and to develop a shared ethic 
      of care and professional identity. Our findings also indicate the decline of
      'catching up' between nurses along with diminishing time and opportunity for
      staff to care holistically for patients in present service climates.
FAU - Adams, Mary
AU  - Adams M
AD  - Kings College London, UK. mary.adams@kcl.ac.uk
FAU - Robert, Glenn
AU  - Robert G
FAU - Maben, Jill
AU  - Maben J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121018
PL  - England
TA  - Health (London)
JT  - Health (London, England : 1997)
JID - 9800465
SB  - IM
MH  - Community Health Nursing/methods/organization & administration/standards
MH  - England
MH  - Home Health Nursing/*methods/organization & administration/standards
MH  - Humans
MH  - Interviews as Topic
MH  - Nurse-Patient Relations
MH  - Nursing Process
MH  - Quality of Health Care
MH  - Workplace/psychology
OTO - NOTNLM
OT  - Ethnography
OT  - health policy
OT  - organization of health services
OT  - patient-physician relationship
EDAT- 2012/10/20 06:00
MHDA- 2014/03/04 06:00
CRDT- 2012/10/20 06:00
PHST- 2012/10/20 06:00 [entrez]
PHST- 2012/10/20 06:00 [pubmed]
PHST- 2014/03/04 06:00 [medline]
AID - 1363459312460703 [pii]
AID - 10.1177/1363459312460703 [doi]
PST - ppublish
SO  - Health (London). 2013 Jul;17(4):422-38. doi: 10.1177/1363459312460703. Epub 2012 
      Oct 18.


PMID- 23079306
OWN - NLM
STAT- MEDLINE
DCOM- 20130403
LR  - 20161125
IS  - 1744-134X (Electronic)
IS  - 1744-1331 (Linking)
VI  - 7
IP  - 4
DP  - 2012 Oct
TI  - Dementia, death and advance directives.
PG  - 499-506
LID - 10.1017/S1744133112000278 [doi]
AB  - This article considers the ethics of advance directives, especially in relation
      to conditions such as dementia. For some choices, such as over whether one's life
      should end at home or in a hospice, advance directives can be very enlightened
      and helpful. For others, such as those to end the life of an autonomous subject, 
      against their will, have no moral appeal and would rightly be ignored. In a wide 
      range of intermediate cases, given our typical lack of insight into how changes
      in our health condition will affect us in other ways, we should be very cautious 
      indeed in promoting the use of advance directives in end-of-life decisions, at
      least where a reasonable quality of life remains. There may be some reasons for
      giving priority to the earlier autonomous self over a later, contented but
      non-autonomous self, but these reasons seem far from compelling.
FAU - Wolff, Jonathan
AU  - Wolff J
AD  - Department of Philosophy, University College London, London, UK.
      j.wolff@ucl.ac.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - Health Econ Policy Law
JT  - Health economics, policy, and law
JID - 101247224
SB  - IM
MH  - Advance Directives/ethics/*legislation & jurisprudence
MH  - *Attitude to Death
MH  - Dementia/*mortality/psychology
MH  - Hospice Care/ethics
MH  - Humans
MH  - Quality of Life/*psychology
MH  - United Kingdom
EDAT- 2012/10/20 06:00
MHDA- 2013/04/04 06:00
CRDT- 2012/10/20 06:00
PHST- 2012/10/20 06:00 [entrez]
PHST- 2012/10/20 06:00 [pubmed]
PHST- 2013/04/04 06:00 [medline]
AID - S1744133112000278 [pii]
AID - 10.1017/S1744133112000278 [doi]
PST - ppublish
SO  - Health Econ Policy Law. 2012 Oct;7(4):499-506. doi: 10.1017/S1744133112000278.


PMID- 23079305
OWN - NLM
STAT- MEDLINE
DCOM- 20130403
LR  - 20121019
IS  - 1744-134X (Electronic)
IS  - 1744-1331 (Linking)
VI  - 7
IP  - 4
DP  - 2012 Oct
TI  - End-of-life care for patients with dementia in the United States: institutional
      realities.
PG  - 485-98
LID - 10.1017/S1744133112000266 [doi]
AB  - Few are satisfied with end-of-life care in the United States. For families and
      friends of people with dementia, end-of-life care is particularly frustrating.
      Providing better end-of-life care to people with dementia is urgent because the
      prevalence of the disease is increasing rapidly. Dementia is currently the
      seventh leading cause of death in the United States and fifth leading cause of
      death among people aged 65 years and older. By 2050, there will be around 19
      million people with Alzheimer's disease. This article reviews ethical and policy 
      challenges associated with providing end-of-life care for people with dementia in
      the United States. I explain how disagreements about the meaning of futility lead
      to poor care for people with dementia. Most people agree that we should not
      provide care that is futile, but there is little agreement about how futility
      should be defined. US policies and politics clearly tip the balance in the
      direction of treatment, even in the face of strong evidence that such care does
      more harm than good. Although we may never reach a consensus, it is important to 
      address these questions and think about how to develop policies that respect the 
      different values.
FAU - Gusmano, Michael
AU  - Gusmano M
AD  - New York Medical College, Valhalla, NY 10595, USA. Michael_Gusmano@nymc.edu
LA  - eng
PT  - Journal Article
PL  - England
TA  - Health Econ Policy Law
JT  - Health economics, policy, and law
JID - 101247224
SB  - IM
MH  - Advance Directives/ethics/*legislation & jurisprudence
MH  - Alzheimer Disease/mortality
MH  - Decision Making
MH  - Dementia/*mortality
MH  - Health Policy/*legislation & jurisprudence
MH  - Humans
MH  - Motivation
MH  - Palliative Care/*methods
MH  - *Personal Autonomy
MH  - Politics
MH  - Terminal Care/*methods
MH  - United States
EDAT- 2012/10/20 06:00
MHDA- 2013/04/04 06:00
CRDT- 2012/10/20 06:00
PHST- 2012/10/20 06:00 [entrez]
PHST- 2012/10/20 06:00 [pubmed]
PHST- 2013/04/04 06:00 [medline]
AID - S1744133112000266 [pii]
AID - 10.1017/S1744133112000266 [doi]
PST - ppublish
SO  - Health Econ Policy Law. 2012 Oct;7(4):485-98. doi: 10.1017/S1744133112000266.


PMID- 23079046
OWN - NLM
STAT- MEDLINE
DCOM- 20130709
LR  - 20161125
IS  - 1872-7727 (Electronic)
IS  - 0720-048X (Linking)
VI  - 82
IP  - 2
DP  - 2013 Feb
TI  - Comparative study of DTS and CT in the skeletal trauma imaging diagnosis
      evaluation and radiation dose.
PG  - e76-80
LID - 10.1016/j.ejrad.2012.09.008 [doi]
LID - S0720-048X(12)00444-5 [pii]
AB  - PURPOSE: To compare the differences between CT (Computed tomography) and DTS
      (digital tomosynthesis) in the X-ray radiation dose, and to analyze the
      sensitivity and specificity of each examination to check the suspected fractures 
      and dislocations cases. METHODS: From May 2010 to February 2012, 46 patients
      suspected with fractures and/or dislocations were prospectively enrolled to do
      the CT and DTS examination on the basis of the results of DR examination.
      Patients were considered ineligible if they were pregnant or lactating (female
      subjects only). The Yangzhou Regional Ethical Review Board in Jiangsu province,
      China approved this study. All 46 patients signed the informed consent. To
      contrast radiation dose between CT and DTS group of the patients and make
      statistical analysis. Two experienced experts assess the image quality by I-III
      grade and make statistical analysis. Draw the ROC of reader A and B according to 
      the golden standard of clinical diagnosis. RESULTS: The average effective dose of
      CT Group is 5.46 msv, while average effective dose of DTS group is 0.07 msv.There
      is significant statistical difference (t=22.89, p<0.01) between them. Calculate
      and compare the area under the ROC curve of reader A and B. The area of reader A 
      by CT and DTS is 0.999 +/- 0.005, 0.973 +/- 0.022. The area of reader B is 0.961 
      +/- 0.026, 0.944 +/- 0.032. Both of them perform z test, and P>0.05. There is no 
      significant difference. Assess the uniformity of two readers with Kappa test. The
      Kappa value of reader A and B is respectively 0.757 and 0.783. When the value is 
      greater than 0.75, two readers' uniformity is considered well. The two readers'
      sensitivity and specificity in diagnosing hidden skeletal trauma with CT and DTS 
      are respectively 97.06% (reader A), 96.97% (reader B); 91.67% (reader A), 84.62% 
      (reader B). Use the chi(2) test to them, then get the same result: P>0.05. There 
      is no statistical significant. CONCLUSION: Radiation dose of VolumnRAD DTS only
      account for 1.5% of CT, but its image can meet the requirements for clinical
      diagnosis. When fracture and/or dislocation is suspected with DR, VolumnRAD DTS
      can be recommended firstly as further checks.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Xia, Wei
AU  - Xia W
AD  - Clinical Medical College, Yangzhou University, Subei People's Hospital of Jiangsu
      Province, Yangzhou 225001, China. gangqiaxia@163.com
FAU - Yin, Xiao-rui
AU  - Yin XR
FAU - Wu, Jing-Tao
AU  - Wu JT
FAU - Wu, Hai-tao
AU  - Wu HT
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20121015
PL  - Ireland
TA  - Eur J Radiol
JT  - European journal of radiology
JID - 8106411
SB  - IM
EIN - Eur J Radiol. 2013 Nov;82(11):2068
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Body Burden
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Fractures, Bone/*diagnostic imaging
MH  - Humans
MH  - Joint Dislocations/*diagnostic imaging
MH  - Male
MH  - Middle Aged
MH  - *Radiation Dosage
MH  - Radiographic Image Enhancement/*methods
MH  - Radiometry
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Tomography, X-Ray Computed/*methods
MH  - Young Adult
EDAT- 2012/10/20 06:00
MHDA- 2013/07/10 06:00
CRDT- 2012/10/20 06:00
PHST- 2012/07/02 00:00 [received]
PHST- 2012/09/19 00:00 [revised]
PHST- 2012/09/21 00:00 [accepted]
PHST- 2012/10/20 06:00 [entrez]
PHST- 2012/10/20 06:00 [pubmed]
PHST- 2013/07/10 06:00 [medline]
AID - S0720-048X(12)00444-5 [pii]
AID - 10.1016/j.ejrad.2012.09.008 [doi]
PST - ppublish
SO  - Eur J Radiol. 2013 Feb;82(2):e76-80. doi: 10.1016/j.ejrad.2012.09.008. Epub 2012 
      Oct 15.


PMID- 23078725
OWN - NLM
STAT- MEDLINE
DCOM- 20130517
LR  - 20171116
IS  - 1365-2923 (Electronic)
IS  - 0308-0110 (Linking)
VI  - 46
IP  - 11
DP  - 2012 Nov
TI  - Making film vignettes to teach medical ethics.
PG  - 1133-4
LID - 10.1111/medu.12027 [doi]
FAU - Johnston, Carolyn
AU  - Johnston C
AD  - Department of Medical Education, School of Medicine, King's College London, 4.18 
      Shepherd's House, Guy's Campus, London SE1 9RT, UK. carolyn.johnston@kcl.ac.uk
FAU - Chan, Mark
AU  - Chan M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Med Educ
JT  - Medical education
JID - 7605655
SB  - IM
MH  - Curriculum
MH  - Ethics, Medical/*education
MH  - Humans
MH  - *Motion Pictures
MH  - Physician-Patient Relations
MH  - Teaching/methods
EDAT- 2012/10/20 06:00
MHDA- 2013/05/18 06:00
CRDT- 2012/10/20 06:00
PHST- 2012/10/20 06:00 [entrez]
PHST- 2012/10/20 06:00 [pubmed]
PHST- 2013/05/18 06:00 [medline]
AID - 10.1111/medu.12027 [doi]
PST - ppublish
SO  - Med Educ. 2012 Nov;46(11):1133-4. doi: 10.1111/medu.12027.


PMID- 23078680
OWN - NLM
STAT- MEDLINE
DCOM- 20130517
LR  - 20220321
IS  - 1365-2923 (Electronic)
IS  - 0308-0110 (Linking)
VI  - 46
IP  - 11
DP  - 2012 Nov
TI  - Outcomes of longitudinal integrated clinical placements for students, clinicians 
      and society.
PG  - 1028-41
LID - 10.1111/j.1365-2923.2012.04331.x [doi]
AB  - CONTEXT: Longitudinal integrated clerkships (LICs) have been widely implemented
      in both rural and urban contexts, as is now evident in the wealth of studies
      published internationally. This narrative literature review aims to summarise
      current evidence regarding the outcomes of LICs for student, clinician and
      community stakeholders. METHODS: Recent literature was examined for original
      research articles pertaining to outcomes of LICs. RESULTS: Students in LICs
      achieve academic results equivalent to and in some cases better than those of
      their counterparts who receive clinical education in block rotations. Students in
      LICs are reported to have well-developed patient-centred communication skills,
      demonstrate understanding of the psychosocial contributions to medicine, and
      report more preparedness in higher-order clinical and cognitive skills in
      comparison with students in traditional block rotations (TBRs). Students in LICs 
      take on increased responsibility with patients and describe having more
      confidence in dealing with ethical dilemmas. Continuity of supervision reportedly
      facilitates incremental knowledge acquisition, and supervisors provide
      incrementally progressive feedback. Despite early disorientation regarding the
      organising of their learning, students feel well supported by the continuity of
      student-preceptor relationships and value the contributions made by these.
      Students in LICs living and working in rural areas are positively influenced
      towards primary care and rural career choices. DISCUSSION: A sound body of
      knowledge in the field of LIC research suggests it is time to move beyond
      descriptive or exploratory research that is designed to justify this new
      educational approach by comparing academic results. As the attributes of LIC
      alumni are better understood, it is important to conduct explanatory research to 
      develop a more complete understanding of these findings and a foundation for new 
      theoretical frameworks that underpin educational change. CONCLUSIONS:
      Longitudinal integrated clerkships are now recognised as representing credible
      and effective pedagogical alternatives to TBRs in medical education.
CI  - (c) Blackwell Publishing Ltd 2012.
FAU - Walters, Lucie
AU  - Walters L
AD  - Flinders University Rural Clinical School, Faculty of Health Sciences, Flinders
      University, Mount Gambier, South Australia, Australia.
      lucie.walters@flinders.edu.au
FAU - Greenhill, Jennene
AU  - Greenhill J
FAU - Richards, Janet
AU  - Richards J
FAU - Ward, Helena
AU  - Ward H
FAU - Campbell, Narelle
AU  - Campbell N
FAU - Ash, Julie
AU  - Ash J
FAU - Schuwirth, Lambert W T
AU  - Schuwirth LW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Med Educ
JT  - Medical education
JID - 7605655
SB  - IM
CIN - Med Educ. 2012 Nov;46(11):1024-6. PMID: 23078678
MH  - Clinical Clerkship/*methods/standards/statistics & numerical data
MH  - Clinical Competence
MH  - Education, Medical/methods
MH  - Educational Status
MH  - Humans
MH  - Students, Medical/statistics & numerical data
EDAT- 2012/10/20 06:00
MHDA- 2013/05/18 06:00
CRDT- 2012/10/20 06:00
PHST- 2012/10/20 06:00 [entrez]
PHST- 2012/10/20 06:00 [pubmed]
PHST- 2013/05/18 06:00 [medline]
AID - 10.1111/j.1365-2923.2012.04331.x [doi]
PST - ppublish
SO  - Med Educ. 2012 Nov;46(11):1028-41. doi: 10.1111/j.1365-2923.2012.04331.x.


PMID- 23078642
OWN - NLM
STAT- MEDLINE
DCOM- 20130904
LR  - 20121019
IS  - 1557-8070 (Electronic)
IS  - 1557-8070 (Linking)
VI  - 12
IP  - 10
DP  - 2012 Oct
TI  - Critical issues in the history, philosophy, and sociology of astrobiology.
PG  - 906-27
LID - 10.1089/ast.2011.0786 [doi]
AB  - Fifty years after serious scientific research began in the field of exobiology,
      and forty years after serious historical research began on the subject of
      extraterrestrial life, this paper identifies and examines some of the most
      important issues in the history, philosophy, and sociology of what is today known
      as astrobiology. As in the philosophy of science in general, and in the
      philosophies of particular sciences, critical issues in the philosophy and
      sociology of astrobiology are both stimulated and illuminated by history. Among
      those issues are (1) epistemological issues such as the status of astrobiology as
      a science, the problematic nature of evidence and inference, and the limits of
      science; (2) metaphysical/scientific issues, including the question of defining
      the fundamental concepts of life, mind, intelligence, and culture in a universal 
      context; the role of contingency and necessity in the origin of these fundamental
      phenomena; and whether or not the universe is in some sense fine-tuned for life
      and perhaps biocentric; (3) societal issues such as the theological, ethical, and
      worldview impacts of the discovery of microbial or intelligent life; and the
      question of whether the search for extraterrestrial life should be pursued at
      all, and with what precautions; and (4) issues related to the sociology of
      scientific knowledge, including the diverse attitudes and assumptions of
      different scientific communities and different cultures to the problem of life
      beyond Earth, the public "will to believe," and the formation of the discipline
      of astrobiology. All these overlapping issues are framed by the concept of cosmic
      evolution-the 13.7 billion year Master Narrative of the Universe-which may result
      in a physical, biological, or postbiological universe and determine the long-term
      destiny of humanity.
FAU - Dick, Steven J
AU  - Dick SJ
AD  - National Air and Space Museum, Smithsonian Institution, Washington, DC, USA.
      stevedick1@comcast.net
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - Astrobiology
JT  - Astrobiology
JID - 101088083
SB  - IM
MH  - Exobiology/ethics/*history
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Knowledge
MH  - Metaphysics
MH  - *Philosophy
MH  - Societies
MH  - *Sociology
EDAT- 2012/10/20 06:00
MHDA- 2013/09/05 06:00
CRDT- 2012/10/20 06:00
PHST- 2012/10/20 06:00 [entrez]
PHST- 2012/10/20 06:00 [pubmed]
PHST- 2013/09/05 06:00 [medline]
AID - 10.1089/ast.2011.0786 [doi]
PST - ppublish
SO  - Astrobiology. 2012 Oct;12(10):906-27. doi: 10.1089/ast.2011.0786.


PMID- 23078493
OWN - NLM
STAT- MEDLINE
DCOM- 20130118
LR  - 20211021
IS  - 1541-0048 (Electronic)
IS  - 0090-0036 (Linking)
VI  - 102
IP  - 12
DP  - 2012 Dec
TI  - The prompted optional randomization trial: a new design for comparative
      effectiveness research.
PG  - e8-10
LID - 10.2105/AJPH.2012.301036 [doi]
AB  - Randomized controlled trials are the gold standard for medical evidence because
      randomization provides the best-known protection against confounding of results. 
      Randomization has practical and ethical problems that limit the number of trials 
      that can be conducted, however. A different method for collecting clinical data
      retains the statistically useful properties of randomization without incurring
      its practical and ethical challenges. A computerized prompt introduces a random
      element into clinical decision-making that can be instantly overridden if it
      conflicts with optimal patient care. This creates a weak form of randomization
      that still eliminates the effect of all confounders, can be carried out without
      disturbing routine clinical care, and arguably will not require research-grade
      informed consent.
FAU - Flory, James
AU  - Flory J
AD  - Department of Medicine, Weill Cornell School of Medicine, New York, NY, USA.
      jaf9052@nyp.org
FAU - Karlawish, Jason
AU  - Karlawish J
LA  - eng
GR  - P30 AG010124/AG/NIA NIH HHS/United States
GR  - P30AG-01024/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20121018
PL  - United States
TA  - Am J Public Health
JT  - American journal of public health
JID - 1254074
SB  - IM
MH  - Comparative Effectiveness Research/ethics/*methods
MH  - Data Interpretation, Statistical
MH  - Humans
MH  - Informed Consent/ethics
MH  - Medical Order Entry Systems
MH  - Random Allocation
MH  - Randomized Controlled Trials as Topic/ethics/*methods
PMC - PMC3519302
EDAT- 2012/10/20 06:00
MHDA- 2013/01/19 06:00
CRDT- 2012/10/20 06:00
PHST- 2012/10/20 06:00 [entrez]
PHST- 2012/10/20 06:00 [pubmed]
PHST- 2013/01/19 06:00 [medline]
AID - 10.2105/AJPH.2012.301036 [doi]
PST - ppublish
SO  - Am J Public Health. 2012 Dec;102(12):e8-10. doi: 10.2105/AJPH.2012.301036. Epub
      2012 Oct 18.


PMID- 23078484
OWN - NLM
STAT- MEDLINE
DCOM- 20130118
LR  - 20211021
IS  - 1541-0048 (Electronic)
IS  - 0090-0036 (Linking)
VI  - 102
IP  - 12
DP  - 2012 Dec
TI  - Ethical issues in health research with novel online sources.
PG  - 2225-30
LID - 10.2105/AJPH.2012.300813 [doi]
AB  - Health-related research is increasingly drawing on novel sources of online data, 
      such as crowdsourced information about disease outbreaks, consumer-supplied
      information provided to health or wellness Web sites, Internet search queries
      about personal health, and social network postings that identify health
      behaviors. We offer examples of online sources and their uses, identify ethical
      and policy issues they generate, and formulate key questions for future
      discussion and investigation. Further work in this area will require
      cross-disciplinary collaboration to develop ethics and policy guidance for the
      ethical use of these novel data sources in health-related research.
FAU - Vayena, Effy
AU  - Vayena E
AD  - Institute of Biomedical Ethics, University of Zurich, Zurich, Switzerland.
      vayena@ethik.uzh.ch
FAU - Mastroianni, Anna
AU  - Mastroianni A
FAU - Kahn, Jeffrey
AU  - Kahn J
LA  - eng
PT  - Journal Article
DEP - 20121018
PL  - United States
TA  - Am J Public Health
JT  - American journal of public health
JID - 1254074
SB  - IM
MH  - Biomedical Research/*ethics/methods
MH  - Cooperative Behavior
MH  - Health Information Systems
MH  - Humans
MH  - Internet
MH  - Online Systems/*ethics
MH  - Public Policy
PMC - PMC3519346
EDAT- 2012/10/20 06:00
MHDA- 2013/01/19 06:00
CRDT- 2012/10/20 06:00
PHST- 2012/10/20 06:00 [entrez]
PHST- 2012/10/20 06:00 [pubmed]
PHST- 2013/01/19 06:00 [medline]
AID - 10.2105/AJPH.2012.300813 [doi]
PST - ppublish
SO  - Am J Public Health. 2012 Dec;102(12):2225-30. doi: 10.2105/AJPH.2012.300813. Epub
      2012 Oct 18.


PMID- 23078472
OWN - NLM
STAT- MEDLINE
DCOM- 20130118
LR  - 20211021
IS  - 1541-0048 (Electronic)
IS  - 0090-0036 (Linking)
VI  - 102
IP  - 12
DP  - 2012 Dec
TI  - Playing hockey, riding motorcycles, and the ethics of protection.
PG  - 2214-20
LID - 10.2105/AJPH.2012.300721 [doi]
AB  - Ice hockey and motorcycle riding are increasingly popular activities in the
      United States that are associated with high risks of head and facial injuries. In
      both, effective head and facial protective equipment are available. Yet the
      debates about safety policies regarding the use of head protection in these
      activities have taken different forms, in terms of the influence of
      epidemiological data as well as of the ethical concerns raised. I examine these
      debates over injury prevention in the context of leisure activities, in which the
      public health duty to prevent avoidable harm must be balanced with the freedom to
      assume voluntary risks.
FAU - Bachynski, Kathleen E
AU  - Bachynski KE
AD  - Center for the History and Ethics of Public Health, Mailman School of Public
      Health, Columbia University, New York, NY 10032, USA. keb2168@columbia.edu
LA  - eng
PT  - Journal Article
DEP - 20121018
PL  - United States
TA  - Am J Public Health
JT  - American journal of public health
JID - 1254074
SB  - IM
MH  - Adolescent
MH  - Head Protective Devices/*ethics
MH  - Hockey/ethics/*injuries
MH  - Humans
MH  - *Motorcycles/ethics
MH  - Safety
MH  - Wounds and Injuries/prevention & control
MH  - Young Adult
PMC - PMC3519301
EDAT- 2012/10/20 06:00
MHDA- 2013/01/19 06:00
CRDT- 2012/10/20 06:00
PHST- 2012/10/20 06:00 [entrez]
PHST- 2012/10/20 06:00 [pubmed]
PHST- 2013/01/19 06:00 [medline]
AID - 10.2105/AJPH.2012.300721 [doi]
PST - ppublish
SO  - Am J Public Health. 2012 Dec;102(12):2214-20. doi: 10.2105/AJPH.2012.300721. Epub
      2012 Oct 18.


PMID- 23077199
OWN - NLM
STAT- MEDLINE
DCOM- 20130325
LR  - 20161125
IS  - 1541-6100 (Electronic)
IS  - 0022-3166 (Linking)
VI  - 142
IP  - 12
DP  - 2012 Dec
TI  - The metabolites in the tryptophan degradation pathway might be useful to
      determine the tolerable upper intake level of tryptophan intake in rats.
PG  - 2227S-2230S
LID - 10.3945/jn.112.163469 [doi]
AB  - L-Tryptophan (L-Trp) is a rate-limiting amino acid for growth in people from
      underdeveloped countries. Because L-Trp is also a precursor to nicotinamide,
      administration of the free form of L-Trp is a very good method of preventing
      pellagra. Furthermore, L-Trp has shown some effectiveness for the treatment of a 
      variety of other conditions typically associated with low serotonin levels in the
      brain. Therefore, information about the no-observed-adverse-effect level and
      lowest-observed-adverse-effect level of L-Trp is needed. However, it is not
      possible to experimentally obtain such data in humans due to ethical
      considerations. The aim of the present workshop was to identify biomarkers that
      could be used before the appearance of adverse effects of L-Trp. We reviewed the 
      published research using rats to develop an index of the metabolic upper intake
      level for L-Trp to be used instead of the tolerable upper intake level (UL).
      These results show that the urinary excretory ratio of anthranilic acid:kynurenic
      acid is potentially the most sensitive and appropriate surrogate breakpoint index
      to predict the UL of L-Trp.
FAU - Shibata, Katsumi
AU  - Shibata K
AD  - Department of Food Science and Nutrition, School of Human Cultures, The
      University of Shiga Prefecture, Shiga, Japan. kshibata@shc.usp.ac.jp
FAU - Fukuwatari, Tsutomu
AU  - Fukuwatari T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121017
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 0 (Vitamins)
RN  - 0 (ortho-Aminobenzoates)
RN  - 0YS975XI6W (anthranilic acid)
RN  - 25X51I8RD4 (Niacinamide)
RN  - 8DUH1N11BX (Tryptophan)
RN  - H030S2S85J (Kynurenic Acid)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Female
MH  - Humans
MH  - Kynurenic Acid/metabolism
MH  - Male
MH  - Niacinamide/metabolism
MH  - No-Observed-Adverse-Effect Level
MH  - *Nutritional Requirements
MH  - Rats
MH  - Rats, Wistar
MH  - Tryptophan/*administration & dosage/adverse effects/*metabolism
MH  - Vitamins/administration & dosage
MH  - ortho-Aminobenzoates/metabolism
EDAT- 2012/10/19 06:00
MHDA- 2013/03/26 06:00
CRDT- 2012/10/19 06:00
PHST- 2012/10/19 06:00 [entrez]
PHST- 2012/10/19 06:00 [pubmed]
PHST- 2013/03/26 06:00 [medline]
AID - jn.112.163469 [pii]
AID - 10.3945/jn.112.163469 [doi]
PST - ppublish
SO  - J Nutr. 2012 Dec;142(12):2227S-2230S. doi: 10.3945/jn.112.163469. Epub 2012 Oct
      17.


PMID- 23077138
OWN - NLM
STAT- MEDLINE
DCOM- 20130409
LR  - 20200219
IS  - 2561-8741 (Electronic)
IS  - 2561-8741 (Linking)
VI  - 19
IP  - 3
DP  - 2012
TI  - Ethical considerations when communicating a diagnosis of a fetal alcohol spectrum
      disorder to a child.
PG  - e361-8
AB  - Maternal alcohol consumption during pregnancy may result in Fetal Alcohol
      Spectrum Disorder (FASD), which is an umbrella term used to describe a range of
      conditions that are associated with significant neurodevelopmental impairments.
      Communicating an FASD diagnosis to a child is a complex and difficult task that
      requires a great deal of care, particularly due to the sensitive nature of the
      etiology of these disorders. To the best of our knowledge, there are no formal
      guidelines or published materials that outline the ethical considerations
      specifically associated with disclosing an FASD diagnosis to a child. This paper 
      discusses a number of ethical principles and situational factors that should be
      considered when communicating an FASD diagnosis, as well as some of the potential
      risks and benefits associated with disclosure. We also provide recommendations to
      assist clinicians in communicating the diagnosis in a manner that increases
      understanding and minimizes harm to the child. Future recommendations include the
      development of formalized guidelines in order to aid clinicians in carrying out
      this sensitive task.
FAU - Todorow, Michelle
AU  - Todorow M
AD  - Department of Psychology, York University, Toronto, Canada.
      michelle.todorow@sickkids.ca
FAU - Paris, Karrela
AU  - Paris K
FAU - Fantus, Ellen
AU  - Fantus E
LA  - eng
PT  - Journal Article
DEP - 20121011
PL  - Australia
TA  - J Popul Ther Clin Pharmacol
JT  - Journal of population therapeutics and clinical pharmacology = Journal de la
      therapeutique des populations et de la pharmacologie clinique
JID - 101530023
SB  - IM
MH  - Child
MH  - *Communication
MH  - *Ethics, Medical
MH  - Female
MH  - Fetal Alcohol Spectrum Disorders/*diagnosis/psychology
MH  - Humans
MH  - Physician-Patient Relations
MH  - Pregnancy
MH  - Truth Disclosure/*ethics
EDAT- 2012/10/19 06:00
MHDA- 2013/04/10 06:00
CRDT- 2012/10/19 06:00
PHST- 2012/10/19 06:00 [entrez]
PHST- 2012/10/19 06:00 [pubmed]
PHST- 2013/04/10 06:00 [medline]
PST - ppublish
SO  - J Popul Ther Clin Pharmacol. 2012;19(3):e361-8. Epub 2012 Oct 11.


PMID- 23076962
OWN - NLM
STAT- MEDLINE
DCOM- 20121116
LR  - 20220720
IS  - 1469-493X (Electronic)
IS  - 1361-6137 (Linking)
VI  - 10
DP  - 2012 Oct 17
TI  - New treatments compared to established treatments in randomized trials.
PG  - MR000024
LID - 10.1002/14651858.MR000024.pub3 [doi]
AB  - BACKGROUND: The proportion of proposed new treatments that are 'successful' is of
      ethical, scientific, and public importance. We investigated how often new,
      experimental treatments evaluated in randomized controlled trials (RCTs) are
      superior to established treatments. OBJECTIVES: Our main question was: "On
      average how often are new treatments more effective, equally effective or less
      effective than established treatments?" Additionally, we wanted to explain the
      observed results, i.e. whether the observed distribution of outcomes is
      consistent with the 'uncertainty requirement' for enrollment in RCTs. We also
      investigated the effect of choice of comparator (active versus no
      treatment/placebo) on the observed results. SEARCH METHODS: We searched the
      Cochrane Methodology Register (CMR) 2010, Issue 1 in The Cochrane Library
      (searched 31 March 2010); MEDLINE Ovid 1950 to March Week 2 2010 (searched 24
      March 2010); and EMBASE Ovid 1980 to 2010 Week 11 (searched 24 March 2010).
      SELECTION CRITERIA: Cohorts of studies were eligible for the analysis if they met
      all of the following criteria: (i) consecutive series of RCTs, (ii) registered at
      or before study onset, and (iii) compared new against established treatments in
      humans. DATA COLLECTION AND ANALYSIS: RCTs from four cohorts of RCTs met all
      inclusion criteria and provided data from 743 RCTs involving 297,744 patients.
      All four cohorts consisted of publicly funded trials. Two cohorts involved
      evaluations of new treatments in cancer, one in neurological disorders, and one
      for mixed types of diseases. We employed kernel density estimation, meta-analysis
      and meta-regression to assess the probability of new treatments being superior to
      established treatments in their effect on primary outcomes and overall survival. 
      MAIN RESULTS: The distribution of effects seen was generally symmetrical in the
      size of difference between new versus established treatments. Meta-analytic
      pooling indicated that, on average, new treatments were slightly more favorable
      both in terms of their effect on reducing the primary outcomes (hazard ratio
      (HR)/odds ratio (OR) 0.91, 99% confidence interval (CI) 0.88 to 0.95) and
      improving overall survival (HR 0.95, 99% CI 0.92 to 0.98). No heterogeneity was
      observed in the analysis based on primary outcomes or overall survival (I(2) =
      0%). Kernel density analysis was consistent with the meta-analysis, but showed a 
      fairly symmetrical distribution of new versus established treatments indicating
      unpredictability in the results. This was consistent with the interpretation that
      new treatments are only slightly superior to established treatments when tested
      in RCTs. Additionally, meta-regression demonstrated that results have remained
      stable over time and that the success rate of new treatments has not changed over
      the last half century of clinical trials. The results were not significantly
      affected by the choice of comparator (active versus placebo/no therapy). AUTHORS'
      CONCLUSIONS: Society can expect that slightly more than half of new experimental 
      treatments will prove to be better than established treatments when tested in
      RCTs, but few will be substantially better. This is an important finding for
      patients (as they contemplate participation in RCTs), researchers (as they plan
      design of the new trials), and funders (as they assess the 'return on
      investment'). Although we provide the current best evidence on the question of
      expected 'success rate' of new versus established treatments consistent with a
      priori theoretical predictions reflective of 'uncertainty or equipoise
      hypothesis', it should be noted that our sample represents less than 1% of all
      available randomized trials; therefore, one should exercise the appropriate
      caution in interpretation of our findings. In addition, our conclusion applies to
      publicly funded trials only, as we did not include studies funded by commercial
      sponsors in our analysis.
FAU - Djulbegovic, Benjamin
AU  - Djulbegovic B
AD  - USF Clinical Translational Science Institute, Dpts of Medicine, Hematology and
      Health Outcome Research, USF and H. LeeMoffitt Cancer Center, USF Health Clinical
      Research, University of South Florida, Tampa, Florida, USA.
      benjamin.djulbegovic@moffitt.org
FAU - Kumar, Ambuj
AU  - Kumar A
FAU - Glasziou, Paul P
AU  - Glasziou PP
FAU - Perera, Rafael
AU  - Perera R
FAU - Reljic, Tea
AU  - Reljic T
FAU - Dent, Louise
AU  - Dent L
FAU - Raftery, James
AU  - Raftery J
FAU - Johansen, Marit
AU  - Johansen M
FAU - Di Tanna, Gian Luca
AU  - Di Tanna GL
FAU - Miladinovic, Branko
AU  - Miladinovic B
FAU - Soares, Heloisa P
AU  - Soares HP
FAU - Vist, Gunn E
AU  - Vist GE
FAU - Chalmers, Iain
AU  - Chalmers I
LA  - eng
GR  - 1 R01 NS052956-01/NS/NINDS NIH HHS/United States
GR  - R01 CA140408/CA/NCI NIH HHS/United States
GR  - R01 NS044417/NS/NINDS NIH HHS/United States
GR  - R01 NS052956/NS/NINDS NIH HHS/United States
GR  - 1R01CA133594-01/CA/NCI NIH HHS/United States
GR  - 1R01NS044417-01/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20121017
PL  - England
TA  - Cochrane Database Syst Rev
JT  - The Cochrane database of systematic reviews
JID - 100909747
SB  - IM
MH  - Financing, Government
MH  - Humans
MH  - Randomized Controlled Trials as Topic/ethics/*standards
MH  - Reference Standards
MH  - Therapies, Investigational/ethics/*standards
MH  - *Treatment Outcome
PMC - PMC3490226
MID - NIHMS413737
EDAT- 2012/10/19 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/10/19 06:00
PHST- 2012/10/19 06:00 [entrez]
PHST- 2012/10/19 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1002/14651858.MR000024.pub3 [doi]
PST - epublish
SO  - Cochrane Database Syst Rev. 2012 Oct 17;10:MR000024. doi:
      10.1002/14651858.MR000024.pub3.


PMID- 23076396
OWN - NLM
STAT- MEDLINE
DCOM- 20130418
LR  - 20191210
IS  - 1472-4146 (Electronic)
IS  - 0021-9746 (Linking)
VI  - 66
IP  - 3
DP  - 2013 Mar
TI  - The practicalities of using tissue slices as preclinical organotypic breast
      cancer models.
PG  - 253-5
LID - 10.1136/jclinpath-2012-201147 [doi]
AB  - Models considering breast cancer complexity cannot be easily or accurately
      replicated in routine cell line or animal models. We aimed to evaluate the
      practicality of organotypic tissue slice culture in breast cancer. Following
      ethical approval, 250 microm thick sections from surplus breast tumours (n=10)
      were prepared using a vibrating blade microtome. Triplicate tissue slices were
      placed in 6-well plates and cultured for up to 7 days +/- tamoxifen (1 nM) or
      doxorubicin (1 microM). Tissue slices were fixed and embedded before sectioning
      for morphological evaluation and immunohistochemistry. H&E showed good
      preservation of tissue morphology. Collagen production was evident. Biomarkers of
      proliferation and apoptosis could be evaluated using immunohistochemistry and
      used as surrogates to quantify drug effects. In summary, breast cancer tissue
      slices can be cultured in vitro as organotypic models. Nevertheless, although
      simple in concept, the delicacy of the model with regard to handling makes
      subsequent analytical processes challenging.
FAU - Holliday, Deborah L
AU  - Holliday DL
AD  - Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK.
FAU - Moss, Marcus A
AU  - Moss MA
FAU - Pollock, Steven
AU  - Pollock S
FAU - Lane, Sally
AU  - Lane S
FAU - Shaaban, Abeer M
AU  - Shaaban AM
FAU - Millican-Slater, Rebecca
AU  - Millican-Slater R
FAU - Nash, Claire
AU  - Nash C
FAU - Hanby, Andrew M
AU  - Hanby AM
FAU - Speirs, Valerie
AU  - Speirs V
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121016
PL  - England
TA  - J Clin Pathol
JT  - Journal of clinical pathology
JID - 0376601
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Biomarkers, Tumor)
RN  - 094ZI81Y45 (Tamoxifen)
RN  - 80168379AG (Doxorubicin)
SB  - IM
MH  - Antineoplastic Agents/*pharmacology
MH  - Apoptosis/drug effects
MH  - Biomarkers, Tumor/metabolism
MH  - Breast/drug effects/metabolism/pathology
MH  - Breast Neoplasms, Male/*drug therapy/metabolism/pathology
MH  - Carcinoma, Ductal, Breast/*drug therapy/metabolism/pathology
MH  - Cell Proliferation/drug effects
MH  - Doxorubicin/pharmacology
MH  - Drug Screening Assays, Antitumor/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Models, Biological
MH  - Tamoxifen/pharmacology
MH  - *Tissue Culture Techniques
EDAT- 2012/10/19 06:00
MHDA- 2013/04/20 06:00
CRDT- 2012/10/19 06:00
PHST- 2012/10/19 06:00 [entrez]
PHST- 2012/10/19 06:00 [pubmed]
PHST- 2013/04/20 06:00 [medline]
AID - jclinpath-2012-201147 [pii]
AID - 10.1136/jclinpath-2012-201147 [doi]
PST - ppublish
SO  - J Clin Pathol. 2013 Mar;66(3):253-5. doi: 10.1136/jclinpath-2012-201147. Epub
      2012 Oct 16.


PMID- 23076344
OWN - NLM
STAT- MEDLINE
DCOM- 20131119
LR  - 20211021
IS  - 1573-3394 (Electronic)
IS  - 1065-3058 (Linking)
VI  - 20
IP  - 4
DP  - 2012 Dec
TI  - Ethical consequences of the positive views of enhancement in Asia.
PG  - 385-97
LID - 10.1007/s10728-012-0230-3 [doi]
AB  - There are positive views towards use of science and technology in all Asian
      countries, and positive views towards use of enhancement in China, India and
      Thailand. After considering of the widespread use of cosmetic surgery and other
      body enhancements in Asian countries, and the generally positive views towards
      letting individuals make choices about improvement of themselves, the paper
      concludes that we can expect other enhancements to also be adopted rapidly in
      Asia. There will be future ethical dilemmas emerging from this with concepts of
      preservation of nature, flow with nature, and definitions of human-ness, along
      with concepts of harmony and social justice. Japan is less willing to engage in
      genetic enhancement compared to China, India and Thailand, despite widespread
      cosmetic surgery across Asia.
FAU - Macer, Darryl
AU  - Macer D
AD  - Regional Unit for Social and Human Sciences in Asia and the Pacific (RUSHSAP),
      UNESCO Bangkok, 920 Sukhumvit Road, Prakanong, Bangkok, 10110, Thailand.
      d.macer@unesco.org
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Health Care Anal
JT  - Health care analysis : HCA : journal of health philosophy and policy
JID - 9432537
MH  - Biomedical Enhancement/*ethics
MH  - China
MH  - Female
MH  - Genetic Engineering/ethics
MH  - Genetic Therapy/ethics
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - India
MH  - Love
MH  - Male
MH  - Personal Autonomy
MH  - Personhood
MH  - Thailand
EDAT- 2012/10/19 06:00
MHDA- 2013/11/20 06:00
CRDT- 2012/10/19 06:00
PHST- 2012/10/19 06:00 [entrez]
PHST- 2012/10/19 06:00 [pubmed]
PHST- 2013/11/20 06:00 [medline]
AID - 10.1007/s10728-012-0230-3 [doi]
PST - ppublish
SO  - Health Care Anal. 2012 Dec;20(4):385-97. doi: 10.1007/s10728-012-0230-3.


PMID- 23075972
OWN - NLM
STAT- MEDLINE
DCOM- 20121204
LR  - 20220316
IS  - 1476-4687 (Electronic)
IS  - 0028-0836 (Linking)
VI  - 490
IP  - 7420
DP  - 2012 Oct 18
TI  - Impact factors: Cash puts publishing ethics at risk in China.
PG  - 342
LID - 10.1038/490342c [doi]
FAU - Huggett, Sarah
AU  - Huggett S
LA  - eng
PT  - Letter
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
SB  - IM
MH  - China
MH  - *Ethics, Research
MH  - *Journal Impact Factor
MH  - Motivation/*ethics
MH  - Publishing/*economics/*ethics
MH  - Research/standards
MH  - Research Personnel/*economics/*ethics/standards
EDAT- 2012/10/19 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/10/19 06:00
PHST- 2012/10/19 06:00 [entrez]
PHST- 2012/10/19 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 490342c [pii]
AID - 10.1038/490342c [doi]
PST - ppublish
SO  - Nature. 2012 Oct 18;490(7420):342. doi: 10.1038/490342c.


PMID- 23075340
OWN - NLM
STAT- MEDLINE
DCOM- 20130916
LR  - 20161125
IS  - 1364-6893 (Electronic)
IS  - 0144-3615 (Linking)
VI  - 32
IP  - 8
DP  - 2012 Nov
TI  - Man-midwifery history: 1730-1930.
PG  - 718-23
LID - 10.3109/01443615.2012.721031 [doi]
AB  - This paper seeks to determine whether the man-midwives William Smellie and
      William Hunter deserve continuing approbation as 'Founding Fathers' of the
      obstetrics profession. Scrutiny of their careers reveals their involvement in
      murders for dissection. In addition, the man-midwifery initiative of delivery in 
      lying-in hospitals resulted in around 1 million more deaths in Britain and
      Ireland between 1730 and 1930, than would have occurred had home-births remained 
      as the norm. While some may still credit Smellie and Hunter with obstetric
      discoveries, their knowledge was obtained by murder-for-dissection. That
      indictment, together with the lying-in hospital legacy, far outweighs their
      discoveries. The paper invites further constructive discussion and debate, but
      concludes the accolade of Founding Fathers is undeserved. Any continuing
      endorsement of Smellie and Hunter effectively demeans the high ethical standards 
      and reputation of current obstetric professionals.
FAU - Shelton, D C
AU  - Shelton DC
AD  - donshelton@actrix.co.nz
LA  - eng
PT  - Biography
PT  - Historical Article
PT  - Journal Article
PL  - England
TA  - J Obstet Gynaecol
JT  - Journal of obstetrics and gynaecology : the journal of the Institute of
      Obstetrics and Gynaecology
JID - 8309140
SB  - IM
CIN - J Obstet Gynaecol. 2012 Nov;32(8):717. PMID: 23075339
MH  - Anatomy/education/history
MH  - Anatomy, Artistic/*history
MH  - Atlases as Topic/*history
MH  - Dissection/history
MH  - Female
MH  - Grave Robbing/history
MH  - History, 18th Century
MH  - History, 19th Century
MH  - History, 20th Century
MH  - Homicide/*history
MH  - Hospitals, Maternity/history
MH  - Humans
MH  - Ireland
MH  - Male
MH  - Maternal Mortality/history
MH  - Midwifery/education/*history
MH  - Obstetrics/ethics/*history
MH  - Pregnancy
MH  - Puerperal Infection/history/mortality
MH  - United Kingdom
MH  - Uterus/anatomy & histology
PS  - Smellie W
FPS - Smellie, William
PS  - Hunter W
FPS - Hunter, William
EDAT- 2012/10/19 06:00
MHDA- 2013/09/17 06:00
CRDT- 2012/10/19 06:00
PHST- 2012/10/19 06:00 [entrez]
PHST- 2012/10/19 06:00 [pubmed]
PHST- 2013/09/17 06:00 [medline]
AID - 10.3109/01443615.2012.721031 [doi]
PST - ppublish
SO  - J Obstet Gynaecol. 2012 Nov;32(8):718-23. doi: 10.3109/01443615.2012.721031.


PMID- 23075258
OWN - NLM
STAT- MEDLINE
DCOM- 20140915
LR  - 20131125
IS  - 1747-4949 (Electronic)
IS  - 1747-4930 (Linking)
VI  - 8
IP  - 8
DP  - 2013 Dec
TI  - ImProving Outcomes after STroke (POST): results from the randomized clinical
      pilot trial.
PG  - 707-10
LID - 10.1111/j.1747-4949.2012.00913.x [doi]
AB  - BACKGROUND: One in three patients experience depression after stroke. An
      effective strategy to prevent depression after stroke that could be economically 
      delivered to most patients with a low likelihood of adverse events is needed.
      METHODS: In a randomized trial conducted in New South Wales, Australia, a
      postcard was sent monthly to participants (n = 100) for five-months following
      hospital discharge after stroke (plus usual care) and compared with usual care (n
      = 101). Ethical approval was obtained to withhold information about the
      intervention and primary outcome from participants during the consent process.
      RESULTS: No significant difference was seen in the proportion of participants
      with depression in the intervention group (1/88) vs. the control group (3/76)
      (relative risk 0.29, 95% confidence interval 0.03-2.71) at six-months. No
      significant differences were seen on Hospital Anxiety Depression Scale (HADS)
      depression and anxiety sub-scale scores, quality of life, or activities of daily 
      living; however, many (47/100) responded positively to the postcards.
      CONCLUSIONS: Although this simple postcard intervention did not significantly
      reduce the proportion of participants experiencing high HADS depression sub-scale
      scores after stroke, it may be an effective way to engage with people after
      stroke following hospital discharge.
CI  - (c) 2012 The Authors. International Journal of Stroke (c) 2012 World Stroke
      Organization.
FAU - Hackett, Maree L
AU  - Hackett ML
AD  - The George Institute for Global Health, The University of Sydney, Sydney, NSW,
      Australia.
FAU - Carter, Greg
AU  - Carter G
FAU - Crimmins, Denis
AU  - Crimmins D
FAU - Clarke, Tracy
AU  - Clarke T
FAU - Arblaster, Lucy
AU  - Arblaster L
FAU - Billot, Laurent
AU  - Billot L
FAU - Mysore, Jayanthi
AU  - Mysore J
FAU - Sturm, Jonathan
AU  - Sturm J
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20121018
PL  - United States
TA  - Int J Stroke
JT  - International journal of stroke : official journal of the International Stroke
      Society
JID - 101274068
SB  - IM
MH  - Aged
MH  - Depression/*etiology/*prevention & control
MH  - Female
MH  - Humans
MH  - Male
MH  - Pilot Projects
MH  - *Postal Service
MH  - *Psychological Techniques
MH  - Stroke/complications/*psychology
OTO - NOTNLM
OT  - clinical trial
OT  - intervention
OT  - ischemic stroke
OT  - prevention
OT  - stroke
OT  - therapy
EDAT- 2012/10/19 06:00
MHDA- 2014/09/16 06:00
CRDT- 2012/10/19 06:00
PHST- 2012/10/19 06:00 [entrez]
PHST- 2012/10/19 06:00 [pubmed]
PHST- 2014/09/16 06:00 [medline]
AID - 10.1111/j.1747-4949.2012.00913.x [doi]
PST - ppublish
SO  - Int J Stroke. 2013 Dec;8(8):707-10. doi: 10.1111/j.1747-4949.2012.00913.x. Epub
      2012 Oct 18.


PMID- 23075022
OWN - NLM
STAT- MEDLINE
DCOM- 20130325
LR  - 20191210
IS  - 1520-5711 (Electronic)
IS  - 1054-3406 (Linking)
VI  - 22
IP  - 6
DP  - 2012
TI  - Regulatory considerations in the design of comparative observational studies
      using propensity scores.
PG  - 1272-9
LID - 10.1080/10543406.2012.715111 [doi]
AB  - In the evaluation of medical products, including drugs, biological products, and 
      medical devices, comparative observational studies could play an important role
      when properly conducted randomized, well-controlled clinical trials are
      infeasible due to ethical or practical reasons. However, various biases could be 
      introduced at every stage and into every aspect of the observational study, and
      consequently the interpretation of the resulting statistical inference would be
      of concern. While there do exist statistical techniques for addressing some of
      the challenging issues, often based on propensity score methodology, these
      statistical tools probably have not been as widely employed in prospectively
      designing observational studies as they should be. There are also times when they
      are implemented in an unscientific manner, such as performing propensity score
      model selection for a dataset involving outcome data in the same dataset, so that
      the integrity of observational study design and the interpretability of outcome
      analysis results could be compromised. In this paper, regulatory considerations
      on prospective study design using propensity scores are shared and illustrated
      with hypothetical examples.
FAU - Yue, Lilly Q
AU  - Yue LQ
AD  - Center for Devices and Radiological Health, US Food and Drug Administration,
      Silver Spring, Maryland 20993, USA. lilly.yue@fda.hhs.gov
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Biopharm Stat
JT  - Journal of biopharmaceutical statistics
JID - 9200436
SB  - IM
MH  - *Bias
MH  - Comparative Effectiveness Research/methods/standards/*statistics & numerical data
MH  - Confounding Factors, Epidemiologic
MH  - Data Interpretation, Statistical
MH  - Device Approval/standards
MH  - Government Regulation
MH  - Humans
MH  - *Models, Statistical
MH  - *Propensity Score
MH  - *Research Design/legislation & jurisprudence/statistics & numerical data
MH  - Treatment Outcome
MH  - United States
MH  - United States Food and Drug Administration
EDAT- 2012/10/19 06:00
MHDA- 2013/03/26 06:00
CRDT- 2012/10/19 06:00
PHST- 2012/10/19 06:00 [entrez]
PHST- 2012/10/19 06:00 [pubmed]
PHST- 2013/03/26 06:00 [medline]
AID - 10.1080/10543406.2012.715111 [doi]
PST - ppublish
SO  - J Biopharm Stat. 2012;22(6):1272-9. doi: 10.1080/10543406.2012.715111.


PMID- 23074993
OWN - NLM
STAT- MEDLINE
DCOM- 20130307
LR  - 20121018
IS  - 1545-5815 (Electronic)
IS  - 0898-9621 (Linking)
VI  - 19
IP  - 6
DP  - 2012
TI  - Asian public concern over the ethics of scientists: predictors and implications
      for research ethics.
PG  - 370-82
LID - 10.1080/08989621.2012.728912 [doi]
AB  - The following two research questions were examined in this study: 1) What is the 
      public's level of concern with ethics in science; and 2) Are religious
      affiliation, religious involvement, and education predictors of that concern in
      Asia? The sample includes 7,963 men and women between the ages of 20 and 59 from 
      ten Asian countries. An overall low level of relative concern toward ethics in
      science was reported. Lower educational attainment was associated with lower odds
      of concern. Christian religious affiliation and moderate religious involvement
      were also associated with lower odds of concern. This article highlights the
      importance of more active research into social perspectives on ethics in science.
FAU - Smolak, Alex
AU  - Smolak A
AD  - Columbia University, School of Social Work, New York, New York 10027, USA.
      as3234@columbia.edu
FAU - Gorroochurn, Prakash
AU  - Gorroochurn P
FAU - Kamarulzaman, Adeeba
AU  - Kamarulzaman A
FAU - Janjua, Nazli
AU  - Janjua N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Account Res
JT  - Accountability in research
JID - 9100813
SB  - IM
MH  - Adult
MH  - Asia
MH  - *Attitude
MH  - Community-Based Participatory Research
MH  - *Ethics, Research
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Religion
MH  - Science/*ethics
MH  - Young Adult
EDAT- 2012/10/19 06:00
MHDA- 2013/03/08 06:00
CRDT- 2012/10/19 06:00
PHST- 2012/10/19 06:00 [entrez]
PHST- 2012/10/19 06:00 [pubmed]
PHST- 2013/03/08 06:00 [medline]
AID - 10.1080/08989621.2012.728912 [doi]
PST - ppublish
SO  - Account Res. 2012;19(6):370-82. doi: 10.1080/08989621.2012.728912.


PMID- 23074992
OWN - NLM
STAT- MEDLINE
DCOM- 20130307
LR  - 20211021
IS  - 1545-5815 (Electronic)
IS  - 0898-9621 (Linking)
VI  - 19
IP  - 6
DP  - 2012
TI  - Reflexive research ethics in fetal tissue xenotransplantation research.
PG  - 344-69
LID - 10.1080/08989621.2012.728910 [doi]
AB  - For biomedical research in which the only involvement of the human subject is the
      provision of tissue or organ samples, a blanket consent, i.e., consent to use the
      tissue for anything researchers wish to do, is considered by many to be adequate 
      for legal and Institutional Review Board (IRB) requirements. Alternatively, a
      detailed informed consent provides patients or study participants with more
      thorough information about the research topic. We document here the beliefs and
      opinions of the research staff on informed consent and the discussion-based
      reflexive research ethics process that we employed in our fetal tissue
      xenotransplantion research on the impact of environmental exposures on fetal
      development. Reflexive research ethics entails the continued adjustment of
      research practice according to relational and reflexive understandings of what
      might be beneficent or harmful. Such reflexivity is not solely an individual
      endeavor, but rather a collective relationship between all actors in the research
      process.
FAU - Panikkar, Bindu
AU  - Panikkar B
AD  - Social Science Environmental Health Research Institute, Northeastern University, 
      Boston, Massachusetts 02115, USA. bpanikkar@hotmail.com
FAU - Smith, Natasha
AU  - Smith N
FAU - Brown, Phil
AU  - Brown P
LA  - eng
GR  - P20 ES018169/ES/NIEHS NIH HHS/United States
GR  - 1P20ES018169/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Account Res
JT  - Accountability in research
JID - 9100813
SB  - IM
MH  - Animals
MH  - *Ethics, Research
MH  - Fetal Tissue Transplantation/*ethics
MH  - Humans
MH  - Informed Consent/*ethics
MH  - *Transplantation, Heterologous
PMC - PMC3689847
MID - NIHMS470419
EDAT- 2012/10/19 06:00
MHDA- 2013/03/08 06:00
CRDT- 2012/10/19 06:00
PHST- 2012/10/19 06:00 [entrez]
PHST- 2012/10/19 06:00 [pubmed]
PHST- 2013/03/08 06:00 [medline]
AID - 10.1080/08989621.2012.728910 [doi]
PST - ppublish
SO  - Account Res. 2012;19(6):344-69. doi: 10.1080/08989621.2012.728910.


PMID- 23074991
OWN - NLM
STAT- MEDLINE
DCOM- 20130307
LR  - 20211021
IS  - 1545-5815 (Electronic)
IS  - 0898-9621 (Linking)
VI  - 19
IP  - 6
DP  - 2012
TI  - Ethical virtues in scientific research.
PG  - 329-43
LID - 10.1080/08989621.2012.728908 [doi]
AB  - Most approaches to promoting integrity in research are principle-based in that
      they portray ethical conduct as consisting of adherence to ethical rules, duties,
      or responsibilities. Bruce MacFarlane has recently criticized the principle-based
      approach to promoting integrity in research and offered a virtue-based
      alternative. MacFarlane argues that principle-based approaches do not provide
      adequate guidance for ethical decision-making and are not very useful in moral
      education. In this article, I examine and critique MacFarlane's defense of the
      virtue-based approach. I argue that virtue-based and principle-based approaches
      to ethics are complementary and that they both can help promote research
      integrity.
FAU - Resnik, David B
AU  - Resnik DB
AD  - National Institute of Environmental Health Sciences, National Institutes of
      Health, Research Triangle Park, North Carolina 27709, USA. resnikd@niehs.nih.gov
LA  - eng
GR  - ZIA ES102646-04/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Account Res
JT  - Accountability in research
JID - 9100813
SB  - IM
MH  - Decision Making
MH  - *Ethical Theory
MH  - *Ethics, Research/education
MH  - Humans
MH  - Mentors
MH  - Principle-Based Ethics
MH  - Teaching
MH  - *Virtues
PMC - PMC3521635
MID - NIHMS426039
EDAT- 2012/10/19 06:00
MHDA- 2013/03/08 06:00
CRDT- 2012/10/19 06:00
PHST- 2012/10/19 06:00 [entrez]
PHST- 2012/10/19 06:00 [pubmed]
PHST- 2013/03/08 06:00 [medline]
AID - 10.1080/08989621.2012.728908 [doi]
PST - ppublish
SO  - Account Res. 2012;19(6):329-43. doi: 10.1080/08989621.2012.728908.


PMID- 23074258
OWN - NLM
STAT- MEDLINE
DCOM- 20130211
LR  - 20220408
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 265
IP  - 3
DP  - 2012 Dec
TI  - Quantitative measurement of brain perfusion with intravoxel incoherent motion MR 
      imaging.
PG  - 874-81
LID - 10.1148/radiol.12120584 [doi]
AB  - PURPOSE: To evaluate the sensitivity of the perfusion parameters derived from
      Intravoxel Incoherent Motion (IVIM) MR imaging to hypercapnia-induced
      vasodilatation and hyperoxygenation-induced vasoconstriction in the human brain. 
      MATERIALS AND METHODS: This study was approved by the local ethics committee and 
      informed consent was obtained from all participants. Images were acquired with a 
      standard pulsed-gradient spin-echo sequence (Stejskal-Tanner) in a clinical 3-T
      system by using 16 b values ranging from 0 to 900 sec/mm(2). Seven healthy
      volunteers were examined while they inhaled four different gas mixtures known to 
      modify brain perfusion (pure oxygen, ambient air, 5% CO(2) in ambient air, and 8%
      CO(2) in ambient air). Diffusion coefficient (D), pseudodiffusion coefficient
      (D*), perfusion fraction (f), and blood flow-related parameter (fD*) maps were
      calculated on the basis of the IVIM biexponential model, and the parametric maps 
      were compared among the four different gas mixtures. Paired, one-tailed Student t
      tests were performed to assess for statistically significant differences.
      RESULTS: Signal decay curves were biexponential in the brain parenchyma of all
      volunteers. When compared with inhaled ambient air, the IVIM perfusion parameters
      D*, f, and fD* increased as the concentration of inhaled CO(2) was increased (for
      the entire brain, P = .01 for f, D*, and fD* for CO(2) 5%; P = .02 for f, and P =
      .01 for D* and fD* for CO(2) 8%), and a trend toward a reduction was observed
      when participants inhaled pure oxygen (although P > .05). D remained globally
      stable. CONCLUSION: The IVIM perfusion parameters were reactive to
      hyperoxygenation-induced vasoconstriction and hypercapnia-induced vasodilatation.
      Accordingly, IVIM imaging was found to be a valid and promising method to
      quantify brain perfusion in humans.
CI  - (c) RSNA, 2012.
FAU - Federau, Christian
AU  - Federau C
AD  - Department of Diagnostic and Interventional Radiology, CHUV, University Hospital 
      Center and University of Lausanne, Rue du Bugnon 46, 1011 Lausanne, Switzerland. 
      christian.federau@chuv.ch
FAU - Maeder, Philippe
AU  - Maeder P
FAU - O'Brien, Kieran
AU  - O'Brien K
FAU - Browaeys, Patrick
AU  - Browaeys P
FAU - Meuli, Reto
AU  - Meuli R
FAU - Hagmann, Patric
AU  - Hagmann P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121016
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 142M471B3J (Carbon Dioxide)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adult
MH  - Air
MH  - Blood Flow Velocity
MH  - Brain/*blood supply/metabolism
MH  - Brain Mapping/*methods
MH  - Carbon Dioxide/administration & dosage
MH  - Female
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Oxygen/administration & dosage
MH  - Prospective Studies
MH  - Sensitivity and Specificity
MH  - Vasoconstriction
MH  - Vasodilation
EDAT- 2012/10/18 06:00
MHDA- 2013/02/12 06:00
CRDT- 2012/10/18 06:00
PHST- 2012/10/18 06:00 [entrez]
PHST- 2012/10/18 06:00 [pubmed]
PHST- 2013/02/12 06:00 [medline]
AID - radiol.12120584 [pii]
AID - 10.1148/radiol.12120584 [doi]
PST - ppublish
SO  - Radiology. 2012 Dec;265(3):874-81. doi: 10.1148/radiol.12120584. Epub 2012 Oct
      16.


PMID- 23074009
OWN - NLM
STAT- MEDLINE
DCOM- 20130321
LR  - 20181202
IS  - 1526-4564 (Electronic)
IS  - 1526-4564 (Linking)
VI  - 30
IP  - 6
DP  - 2012 Dec
TI  - Female obesity and assisted reproductive technologies.
PG  - 507-16
LID - 10.1055/s-0032-1328879 [doi]
AB  - Obesity has grown to epidemic proportions, and currently nearly half of the
      reproductive-age women are overweight or obese. Risks, success rates, and
      economic aspects of infertility treatments in obese women have been extensively
      investigated. Unfavorable ovarian stimulation characteristics like increased
      gonadotropin consumption, fewer selected follicles, and lower number of retrieved
      oocytes have been observed in obese women undergoing assisted reproductive
      technologies (ART). There seems to be a strong association between increased body
      mass index and lower pregnancy and live-birth rates and increased miscarriage
      rate. Coexisting factors like age and polycystic ovary syndrome status have also 
      been blamed for these adverse effects. The mechanisms underlying those adverse
      outcomes, whether ovarian or endometrial, still remain to be fully elucidated.
      Moreover, maternal, perinatal, and neonatal complications have also been reported
      to be higher in obese pregnant women. Hence in some countries strict restrictions
      exist for access to elective fertility treatment in obese women. However, it is
      controversial if these policies are socially and ethically acceptable.
      Furthermore, because weight reduction is not an easy task, it may lead to the
      decreased probability of conception due to the advancing reproductive age for
      many obese women. Thus weight reduction should be encouraged and patients
      counseled accordingly, but whether restriction for fertility treatment is
      implemented in obese women remains a matter of debate. There remains much to be
      known regarding the association between obesity and ART.
CI  - Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
FAU - Kumbak, Banu
AU  - Kumbak B
AD  - IVF Unit, Department of Obstetrics and Gynecology, Firat University Medical
      School, Elazig, Turkey.
FAU - Oral, Engin
AU  - Oral E
FAU - Bukulmez, Orhan
AU  - Bukulmez O
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121016
PL  - United States
TA  - Semin Reprod Med
JT  - Seminars in reproductive medicine
JID - 100909394
SB  - IM
MH  - Female
MH  - Humans
MH  - Infertility/*complications/*therapy
MH  - Obesity/*complications/physiopathology/therapy
MH  - Polycystic Ovary Syndrome/complications/physiopathology/therapy
MH  - Pregnancy
MH  - Reproduction/physiology
MH  - *Reproductive Techniques, Assisted/statistics & numerical data
MH  - Treatment Outcome
MH  - Weight Loss/physiology
EDAT- 2012/10/18 06:00
MHDA- 2013/03/22 06:00
CRDT- 2012/10/18 06:00
PHST- 2012/10/18 06:00 [entrez]
PHST- 2012/10/18 06:00 [pubmed]
PHST- 2013/03/22 06:00 [medline]
AID - 10.1055/s-0032-1328879 [doi]
PST - ppublish
SO  - Semin Reprod Med. 2012 Dec;30(6):507-16. doi: 10.1055/s-0032-1328879. Epub 2012
      Oct 16.


PMID- 23073901
OWN - NLM
STAT- MEDLINE
DCOM- 20140305
LR  - 20211021
IS  - 1432-1076 (Electronic)
IS  - 0340-6199 (Linking)
VI  - 172
IP  - 7
DP  - 2013 Jul
TI  - Ethical aspects of clinical research with minors.
PG  - 859-66
LID - 10.1007/s00431-012-1856-8 [doi]
AB  - Over the past decades, clinical research has increasingly been subjected to
      ethical requirements and legal regulation. The specific focus of ethical and
      legal frameworks on competent adults (which serve as the paradigmatic research
      subject), however, has created an ambivalent attitude towards pediatric clinical 
      research. On one hand, minors are regarded as a vulnerable population that
      deserves additional protection against the risks and burdens involved in clinical
      research. On the other hand, the population of minors should not be denied (or
      not get timely) access to the benefits of clinical research. In this paper, we
      will explore the legal regulation and ethical guidance that currently governs
      pediatric clinical research in the European Union and discuss the future
      challenges in this field. In addition, we will discuss major ethical concerns in 
      pediatric clinical research, with a focus on the acceptability of research risks 
      and the informed consent process. In the discussion, we will address key concerns
      in both regulating pediatric clinical research and implementing ethical and legal
      requirement in the actual pediatric research conduct.
FAU - Bos, Wendy
AU  - Bos W
AD  - Department of Medical Ethics and Philosophy of Medicine, Erasmus Medical Center, 
      P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.
FAU - Tromp, Krista
AU  - Tromp K
FAU - Tibboel, Dick
AU  - Tibboel D
FAU - Pinxten, Wim
AU  - Pinxten W
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121017
PL  - Germany
TA  - Eur J Pediatr
JT  - European journal of pediatrics
JID - 7603873
SB  - IM
MH  - Adolescent
MH  - Biomedical Research/*ethics/legislation & jurisprudence
MH  - Child
MH  - Child, Preschool
MH  - Ethics, Research
MH  - European Union
MH  - Government Regulation
MH  - Humans
MH  - Informed Consent/ethics/legislation & jurisprudence
MH  - Minors/*legislation & jurisprudence
MH  - Pediatrics/*ethics/legislation & jurisprudence
MH  - Research Subjects/*legislation & jurisprudence
EDAT- 2012/10/18 06:00
MHDA- 2014/03/07 06:00
CRDT- 2012/10/18 06:00
PHST- 2012/09/11 00:00 [received]
PHST- 2012/10/02 00:00 [accepted]
PHST- 2012/10/18 06:00 [entrez]
PHST- 2012/10/18 06:00 [pubmed]
PHST- 2014/03/07 06:00 [medline]
AID - 10.1007/s00431-012-1856-8 [doi]
PST - ppublish
SO  - Eur J Pediatr. 2013 Jul;172(7):859-66. doi: 10.1007/s00431-012-1856-8. Epub 2012 
      Oct 17.


PMID- 23073624
OWN - NLM
STAT- MEDLINE
DCOM- 20140616
LR  - 20130910
IS  - 1573-1677 (Electronic)
IS  - 1382-4996 (Linking)
VI  - 18
IP  - 4
DP  - 2013 Oct
TI  - Barriers to undergraduate peer-physical examination of the lower limb in the
      health sciences and strategies to improve inclusion: a review.
PG  - 807-15
LID - 10.1007/s10459-012-9418-4 [doi]
AB  - Peer-physical examination is a widely adopted and an integral component of the
      undergraduate curriculum for many health science programs. Unwillingness or
      perceived inability to participate in peer-physical examination classes may have 
      a negative impact upon students' abilities to competently conduct physical
      examinations of patients in future as registered health professionals. A
      literature review on the perceptions and attitudes of peer-physical examination
      of the lower limb amongst medical and health science students was conducted to
      identify potential barriers to participation, and to review strategies to improve
      participation in classes designed to develop clinical examination skills. A
      pragmatic search strategy of the literature from PubMed and Google Scholar
      published prior to June 2012 yielded 23 relevant articles. All articles were
      concerned with the views of medical students' education and there were no
      articles explicitly addressing the role of peer-physical examination in health
      science disciplines. Several ethical issues were identified including feelings of
      coercion, embarrassment, and perceptions of a lack of consideration for cultural 
      and religious beliefs. The available evidence suggests that barriers to
      participation may be overcome by implementing standard protocols concerned with
      obtaining informed written consent, adequate choice of peer-examiner, changing
      facilities and garment advice, and possible alternative learning methods.
FAU - Hendry, Gordon James
AU  - Hendry GJ
AD  - School of Science and Health, University of Western Sydney, Locked Bag 1797
      Penrith, Sydney, NSW 2751, Australia, gordon.hendry@uws.edu.au.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121017
PL  - Netherlands
TA  - Adv Health Sci Educ Theory Pract
JT  - Advances in health sciences education : theory and practice
JID - 9612021
SB  - IM
MH  - *Attitude
MH  - Cultural Characteristics
MH  - Humans
MH  - Lower Extremity
MH  - *Peer Group
MH  - Physical Examination/*psychology
MH  - Religion
MH  - Students, Health Occupations/*psychology
EDAT- 2012/10/18 06:00
MHDA- 2014/06/17 06:00
CRDT- 2012/10/18 06:00
PHST- 2012/08/28 00:00 [received]
PHST- 2012/10/10 00:00 [accepted]
PHST- 2012/10/18 06:00 [entrez]
PHST- 2012/10/18 06:00 [pubmed]
PHST- 2014/06/17 06:00 [medline]
AID - 10.1007/s10459-012-9418-4 [doi]
PST - ppublish
SO  - Adv Health Sci Educ Theory Pract. 2013 Oct;18(4):807-15. doi:
      10.1007/s10459-012-9418-4. Epub 2012 Oct 17.


PMID- 23073533
OWN - NLM
STAT- MEDLINE
DCOM- 20140428
LR  - 20151119
IS  - 1213-8118 (Print)
IS  - 1213-8118 (Linking)
VI  - 157
IP  - 1
DP  - 2013 Mar
TI  - Quality of life after transcatheter aortic valve implantation and surgical
      replacement in high-risk elderly patients.
PG  - 75-80
LID - 10.5507/bp.2012.062 [doi]
AB  - AIM: The aim of this study was to compare the quality of life after transcatheter
      aortic valve implantation (TAVI) and surgical replacement (SAVR) at one year.
      METHODS: The study included 45 consecutive high-risk patients (average age 82.0
      years; logistic Euroscore 22.3%) with symptomatic severe aortic stenosis
      allocated to TAVI transfemoral, TAVI transapical using the Edwards-Sapien valve
      or SAVR with the Edwards Perimount bioprosthesis (n=15 in each). The
      pre-operative characteristics were similar except for more myocardial infarctions
      in TAVI. The quality of life was assessed using the standardized EQ-5D
      questionnaire at baseline and on days 30, 90 and 360. The protocol was approved
      by the local ethics committee and an informed consent was signed. A total of 7
      patients (15.5%) died during follow-up. RESULTS: At baseline no significant
      differences in any of the quality-of-life parameters were found except for usual 
      activities described as "best" (46.7% in SAVR vs. 10.0% in TAVI; P=0.002). At 30 
      and 90 days surviving patients were similar and at 360 days only the
      anxiety/depression score was "best" in 83.3% SAVR vs. 59.1% (P=0.046). Functional
      status improved in all patients (NYHA class I-II in 13.3% at baseline vs. 78.9%
      at 360-days) and the general health median significantly improved in TAVI
      patients (from 50 to 67; P=0.001) with a positive trend in SAVR patients
      (P=0.060). CONCLUSIONS: At one year, the general quality of life of high-risk
      patients had significantly improved after transcatheter aortic valve implantation
      with a positive trend in surgically treated patients.
FAU - Kala, Petr
AU  - Kala P
AD  - Department of Internal Cardiology Medicine LF MU and FN Brno, Czech Republic.
FAU - Tretina, Martin
AU  - Tretina M
FAU - Poloczek, Martin
AU  - Poloczek M
FAU - Ondrasek, Jiri
AU  - Ondrasek J
FAU - Malik, Petr
AU  - Malik P
FAU - Pokorny, Petr
AU  - Pokorny P
FAU - Parenica, Jiri
AU  - Parenica J
FAU - Spinar, Jindrich
AU  - Spinar J
FAU - Jarkovsky, Jiri
AU  - Jarkovsky J
FAU - Littnerova, Simona
AU  - Littnerova S
FAU - Nemec, Petr
AU  - Nemec P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20120905
PL  - Czech Republic
TA  - Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
JT  - Biomedical papers of the Medical Faculty of the University Palacky, Olomouc,
      Czechoslovakia
JID - 101140142
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aortic Valve Stenosis/psychology/*surgery
MH  - *Cardiac Catheterization/instrumentation/methods
MH  - Female
MH  - Heart Valve Prosthesis
MH  - *Heart Valve Prosthesis Implantation/methods/mortality/psychology
MH  - Humans
MH  - Male
MH  - Prognosis
MH  - *Quality of Life
MH  - Risk Assessment
MH  - Risk Factors
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
EDAT- 2012/10/18 06:00
MHDA- 2014/04/29 06:00
CRDT- 2012/10/18 06:00
PHST- 2012/02/27 00:00 [received]
PHST- 2012/06/11 00:00 [accepted]
PHST- 2012/10/18 06:00 [entrez]
PHST- 2012/10/18 06:00 [pubmed]
PHST- 2014/04/29 06:00 [medline]
AID - 10.5507/bp.2012.062 [doi]
PST - ppublish
SO  - Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2013 Mar;157(1):75-80. doi: 
      10.5507/bp.2012.062. Epub 2012 Sep 5.


PMID- 23073179
OWN - NLM
STAT- MEDLINE
DCOM- 20130501
LR  - 20211021
IS  - 1872-7492 (Electronic)
IS  - 0168-1702 (Linking)
VI  - 170
IP  - 1-2
DP  - 2012 Dec
TI  - Pharmacologic reactivation of latent feline immunodeficiency virus ex vivo in
      peripheral CD4+ T-lymphocytes.
PG  - 174-9
LID - 10.1016/j.virusres.2012.10.009 [doi]
LID - S0168-1702(12)00379-6 [pii]
AB  - FIV establishes a latent infection in peripheral CD4+ T-cells, and the latent FIV
      promoter is associated with deacetylated, methylated histones, consistent with a 
      restrictive chromatin structure. Here we explored the use of 5 histone-modifying 
      agents - 4 histone deacetylase inhibitors (HDACi) and 1 histone methyltransferase
      inhibitor (HMTi) - to reactivate latent FIV ex vivo. All compounds tested were
      able to alter histone lysine residue modifications in feline cells, both globally
      and at the FIV promoter locally. When latently FIV-infected peripheral CD4+
      T-cells were cultured ex vivo in the presence of these inhibitors, viral
      transcription was significantly activated relative to no treatment controls.
      Transcriptional reactivation of virus mediated by the HDACi suberoylanilide
      hydroxamic acid (SAHA) was dose-dependent, detected after as little as 1h of
      exposure, and resulted in virion formation as evidenced by supernatant reverse
      transcriptase activity. A synergistic effect was not found when SAHA was combined
      with HMTi under the conditions tested. At low therapeutically relevant
      concentrations in primary feline PBMC, SAHA was found to be minimally cytotoxic
      and non-immune activating. HDACi and HMTi can reactivate latent FIV ex vivo, and 
      SAHA, also known as the anticancer drug Vorinostat, in particular is a promising 
      candidate for in vivo use because of its efficacy, potency, and relative safety. 
      Use of the FIV/cat model of lentiviral latency to explore in vivo treatment with 
      SAHA and other anti-latency therapeutics will allow investigations that are
      either ethically or logistically not addressable in patients persistently
      infected with human immunodeficiency virus (HIV-1).
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - McDonnel, Samantha J
AU  - McDonnel SJ
AD  - Department of Pathology, Microbiology & Immunology, School of Veterinary
      Medicine, University of California, Davis, 4206 Vet Med 3A, Davis, CA 95616, USA.
      sjmcdonnel@ucdavis.edu
FAU - Sparger, Ellen E
AU  - Sparger EE
FAU - Luciw, Paul A
AU  - Luciw PA
FAU - Murphy, Brian G
AU  - Murphy BG
LA  - eng
GR  - T32 AI060555/AI/NIAID NIH HHS/United States
GR  - T32 RR021312/RR/NCRR NIH HHS/United States
GR  - TL1 RR024145/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121013
PL  - Netherlands
TA  - Virus Res
JT  - Virus research
JID - 8410979
RN  - 0 (Histone Deacetylase Inhibitors)
SB  - IM
MH  - Animals
MH  - CD4-Positive T-Lymphocytes/*drug effects/*virology
MH  - Cats
MH  - Cells, Cultured
MH  - Dose-Response Relationship, Drug
MH  - Histone Deacetylase Inhibitors/pharmacology
MH  - Immunodeficiency Virus, Feline/*drug effects/*physiology
MH  - Leukocytes, Mononuclear/drug effects/virology
MH  - Virus Activation/*drug effects
MH  - Virus Latency/*drug effects
MH  - Virus Replication/drug effects
PMC - PMC3513637
MID - NIHMS414746
EDAT- 2012/10/18 06:00
MHDA- 2013/05/02 06:00
CRDT- 2012/10/18 06:00
PHST- 2012/07/09 00:00 [received]
PHST- 2012/10/07 00:00 [revised]
PHST- 2012/10/08 00:00 [accepted]
PHST- 2012/10/18 06:00 [entrez]
PHST- 2012/10/18 06:00 [pubmed]
PHST- 2013/05/02 06:00 [medline]
AID - S0168-1702(12)00379-6 [pii]
AID - 10.1016/j.virusres.2012.10.009 [doi]
PST - ppublish
SO  - Virus Res. 2012 Dec;170(1-2):174-9. doi: 10.1016/j.virusres.2012.10.009. Epub
      2012 Oct 13.


PMID- 23072719
OWN - NLM
STAT- MEDLINE
DCOM- 20130603
LR  - 20220408
IS  - 1873-5487 (Electronic)
IS  - 0188-4409 (Linking)
VI  - 43
IP  - 7
DP  - 2012 Oct
TI  - Human germline genetic modification: scientific and bioethical perspectives.
PG  - 491-513
LID - 10.1016/j.arcmed.2012.09.003 [doi]
LID - S0188-4409(12)00244-5 [pii]
AB  - The latest mammalian genetic modification technology offers efficient and
      reliable targeting of genomic sequences, in the guise of designer genetic
      recombination tools. These and other improvements in genetic engineering
      technology suggest that human germline genetic modification (HGGM) will become a 
      safe and effective prospect in the relatively near future. Several substantive
      ethical objections have been raised against HGGM including claims of unacceptably
      high levels of risk, damage to the status of future persons, and violations of
      justice and autonomy. This paper critically reviews the latest GM science and
      discusses the key ethical objections to HGGM. We conclude that major benefits are
      likely to accrue through the use of safe and effective HGGM and that it would
      thus be unethical to take a precautionary stance against HGGM.
CI  - Copyright (c) 2012 IMSS. Published by Elsevier Inc. All rights reserved.
FAU - Smith, Kevin R
AU  - Smith KR
AD  - School of Contemporary Sciences, Abertay University, Dundee, United Kingdom.
      k.smith@tay.ac.uk
FAU - Chan, Sarah
AU  - Chan S
FAU - Harris, John
AU  - Harris J
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121013
PL  - United States
TA  - Arch Med Res
JT  - Archives of medical research
JID - 9312706
SB  - IM
CIN - Arch Med Res. 2013 May;44(4):323. PMID: 23684534
CIN - Arch Med Res. 2013 May;44(4):321-2. PMID: 23684666
MH  - Animals
MH  - Embryo Research/ethics
MH  - Embryo, Mammalian/metabolism
MH  - Gene Targeting
MH  - Genetic Engineering/*ethics/methods
MH  - Genetic Enhancement/*ethics/methods
MH  - Germ Cells/*metabolism
MH  - Humans
MH  - Risk Assessment
MH  - Social Justice
EDAT- 2012/10/18 06:00
MHDA- 2013/06/05 06:00
CRDT- 2012/10/18 06:00
PHST- 2012/03/16 00:00 [received]
PHST- 2012/09/06 00:00 [accepted]
PHST- 2012/10/18 06:00 [entrez]
PHST- 2012/10/18 06:00 [pubmed]
PHST- 2013/06/05 06:00 [medline]
AID - S0188-4409(12)00244-5 [pii]
AID - 10.1016/j.arcmed.2012.09.003 [doi]
PST - ppublish
SO  - Arch Med Res. 2012 Oct;43(7):491-513. doi: 10.1016/j.arcmed.2012.09.003. Epub
      2012 Oct 13.


PMID- 23072717
OWN - NLM
STAT- MEDLINE
DCOM- 20131021
LR  - 20130712
IS  - 1365-2648 (Electronic)
IS  - 0309-2402 (Linking)
VI  - 69
IP  - 8
DP  - 2013 Aug
TI  - The extended arm of health professionals? Relatives' experiences of patient's
      recovery in a fast-track programme.
PG  - 1737-46
LID - 10.1111/jan.12034 [doi]
AB  - AIM: To report a study of the lived experience of being a close relative to a
      patient with colon cancer participating in a fast-track programme. BACKGROUND:
      Studies have documented that postoperative recovery can be accelerated and that
      hospitalization can be reduced through fast-track programmes. Due to the early
      discharge and the increasing demands on patients for self-care, patients'
      relatives seem to play a pivotal role in fast-track programmes. However, research
      is limited into how patients' close relatives are affected by and involved in the
      postoperative recovery process. DESIGN: A descriptive phenomenological approach
      using Reflective Lifeworld Research. METHODS: The study was carried out within
      the descriptive phenomenological framework of Reflective Lifeworld Research. Data
      were collected in 2008 from in-depth interviews with twelve relatives. FINDINGS: 
      Relatives experienced a huge responsibility for both the patient's well-being and
      for the patient's compliance with the daily regimen. Relatives were caught in a
      conflicting double role. They were the extended arm of the health professionals
      but also the caring, supporting partner. A tension arose between relatives'
      desire to help the patient by taking an active part in the recovery process and
      the feelings of not always having the resources needed. CONCLUSION: Relatives
      seem to suffer in silence as they bear the burden of the patient's diagnosis, the
      disruption of life, and the taken-for-granted responsibility for the patient's
      recovery process. From an existential perspective, this caring responsibility can
      be understood as ethical pain. Relatives should be seen as a distinct group with 
      special caring needs of their own.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Norlyk, Annelise
AU  - Norlyk A
AD  - Department of Nursing Science, Faculty of Health Sciences, Institute of Clinical 
      Medicine/School of Public Health, Aarhus University, Denmark.
      an@sygeplejevid.au.dk
FAU - Martinsen, Bente
AU  - Martinsen B
LA  - eng
PT  - Journal Article
DEP - 20121017
PL  - England
TA  - J Adv Nurs
JT  - Journal of advanced nursing
JID - 7609811
SB  - IM
MH  - Aged
MH  - *Attitude to Health
MH  - *Caregivers/psychology
MH  - Colonic Neoplasms/nursing/*rehabilitation/surgery
MH  - Denmark
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Patient Discharge
MH  - *Postoperative Care/nursing
MH  - Professional-Family Relations
MH  - Qualitative Research
OTO - NOTNLM
OT  - Reflective Lifeworld Research
OT  - enhanced recovery
OT  - fast-track colonic surgery
OT  - fast-track programme
OT  - lived experience
OT  - nursing
OT  - relatives' experiences
EDAT- 2012/10/18 06:00
MHDA- 2013/10/22 06:00
CRDT- 2012/10/18 06:00
PHST- 2012/09/15 00:00 [accepted]
PHST- 2012/10/18 06:00 [entrez]
PHST- 2012/10/18 06:00 [pubmed]
PHST- 2013/10/22 06:00 [medline]
AID - 10.1111/jan.12034 [doi]
PST - ppublish
SO  - J Adv Nurs. 2013 Aug;69(8):1737-46. doi: 10.1111/jan.12034. Epub 2012 Oct 17.


PMID- 23072681
OWN - NLM
STAT- MEDLINE
DCOM- 20130118
LR  - 20211021
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 12
IP  - 11
DP  - 2012
TI  - Ethics, justice and community participation in the Microbicides Development
      Programme (MDP) Phase III trial in Mwanza, Tanzania.
PG  - 46-8
LID - 10.1080/15265161.2012.719268 [doi]
FAU - Vallely, Andrew
AU  - Vallely A
AD  - University of New SouthWales, Kirby Institute, 45 Beach Street, Coogee, Sydney,
      NSW 2034, Australia. avallely@kirby.unsw.edu.au
FAU - Lees, Shelley
AU  - Lees S
FAU - Shagi, Charles
AU  - Shagi C
FAU - Kapiga, Saidi
AU  - Kapiga S
FAU - McCormack, Sheena
AU  - McCormack S
FAU - Hayes, Richard
AU  - Hayes R
LA  - eng
GR  - G0100137/MRC_/Medical Research Council/United Kingdom
GR  - G0700837/MRC_/Medical Research Council/United Kingdom
GR  - G0901756/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2012;12(11):30-41. PMID: 23072678
MH  - Clinical Trials as Topic/*ethics
MH  - *Developed Countries
MH  - *Developing Countries
MH  - *Ethical Theory
MH  - *Health Status
MH  - *Healthcare Disparities
MH  - Humans
MH  - *Moral Obligations
MH  - Research Personnel/*ethics
MH  - *Social Justice
EDAT- 2012/10/18 06:00
MHDA- 2013/01/19 06:00
CRDT- 2012/10/18 06:00
PHST- 2012/10/18 06:00 [entrez]
PHST- 2012/10/18 06:00 [pubmed]
PHST- 2013/01/19 06:00 [medline]
AID - 10.1080/15265161.2012.719268 [doi]
PST - ppublish
SO  - Am J Bioeth. 2012;12(11):46-8. doi: 10.1080/15265161.2012.719268.


PMID- 23072677
OWN - NLM
STAT- MEDLINE
DCOM- 20130118
LR  - 20211021
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 12
IP  - 11
DP  - 2012
TI  - Are ethics committees in tune with the "epidemiology of ethical issues"?
PG  - 27-9
LID - 10.1080/15265161.2012.719270 [doi]
FAU - Altisent, Rogelio
AU  - Altisent R
AD  - University of Zaragoza, Fernando el Catolico, 59, I, 9 A, Zaragoza, 50006 Spain. 
      rogelioaltisent@gmail.com
FAU - Buil, Begona
AU  - Buil B
FAU - Delgado-Marroquin, Maria Teresa
AU  - Delgado-Marroquin MT
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2012;12(11):3-15. PMID: 23072671
MH  - Advertising/*ethics
MH  - Blood Transfusion/*ethics
MH  - *Ethics Committees, Clinical
MH  - *Ethics, Institutional
MH  - *Health Policy
MH  - Hospitals/*ethics
MH  - Humans
MH  - *Jehovah's Witnesses
MH  - Pediatrics/*ethics
MH  - *Quality Improvement
PMC - PMC3479630
EDAT- 2012/10/18 06:00
MHDA- 2013/01/19 06:00
CRDT- 2012/10/18 06:00
PHST- 2012/10/18 06:00 [entrez]
PHST- 2012/10/18 06:00 [pubmed]
PHST- 2013/01/19 06:00 [medline]
AID - 10.1080/15265161.2012.719270 [doi]
PST - ppublish
SO  - Am J Bioeth. 2012;12(11):27-9. doi: 10.1080/15265161.2012.719270.


PMID- 23072676
OWN - NLM
STAT- MEDLINE
DCOM- 20130118
LR  - 20191210
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 12
IP  - 11
DP  - 2012
TI  - Why the "appraisal of guidelines for research and evaluation" instrument can and 
      should further inform ethics policy work.
PG  - 25-7
LID - 10.1080/15265161.2012.719272 [doi]
FAU - Strech, Daniel
AU  - Strech D
AD  - Hannover Medical School, Institute for History, Ethics and Philosophy of
      Medicine, Carl-Neuberg Str. 1, Hannover, 30625 Germany.
      strech.daniel@mh-hannover.de
FAU - Schildmann, Jan
AU  - Schildmann J
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2012;12(11):3-15. PMID: 23072671
MH  - Advertising/*ethics
MH  - Blood Transfusion/*ethics
MH  - *Ethics Committees, Clinical
MH  - *Ethics, Institutional
MH  - *Health Policy
MH  - Hospitals/*ethics
MH  - Humans
MH  - *Jehovah's Witnesses
MH  - Pediatrics/*ethics
MH  - *Quality Improvement
EDAT- 2012/10/18 06:00
MHDA- 2013/01/19 06:00
CRDT- 2012/10/18 06:00
PHST- 2012/10/18 06:00 [entrez]
PHST- 2012/10/18 06:00 [pubmed]
PHST- 2013/01/19 06:00 [medline]
AID - 10.1080/15265161.2012.719272 [doi]
PST - ppublish
SO  - Am J Bioeth. 2012;12(11):25-7. doi: 10.1080/15265161.2012.719272.


PMID- 23072675
OWN - NLM
STAT- MEDLINE
DCOM- 20130118
LR  - 20191210
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 12
IP  - 11
DP  - 2012
TI  - Hospital ethics committees: the case for limiting policy work.
PG  - 23-4
LID - 10.1080/15265161.2012.719277 [doi]
FAU - Cushman, Reid
AU  - Cushman R
AD  - University of Miami, PO Box 016960, Miami, FL 33101, USA. rcushman@med.miami.edu
FAU - Fiore, Robin N
AU  - Fiore RN
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2012;12(11):3-15. PMID: 23072671
MH  - Advertising/*ethics
MH  - Blood Transfusion/*ethics
MH  - *Ethics Committees, Clinical
MH  - *Ethics, Institutional
MH  - *Health Policy
MH  - Hospitals/*ethics
MH  - Humans
MH  - *Jehovah's Witnesses
MH  - Pediatrics/*ethics
MH  - *Quality Improvement
EDAT- 2012/10/18 06:00
MHDA- 2013/01/19 06:00
CRDT- 2012/10/18 06:00
PHST- 2012/10/18 06:00 [entrez]
PHST- 2012/10/18 06:00 [pubmed]
PHST- 2013/01/19 06:00 [medline]
AID - 10.1080/15265161.2012.719277 [doi]
PST - ppublish
SO  - Am J Bioeth. 2012;12(11):23-4. doi: 10.1080/15265161.2012.719277.


PMID- 23072673
OWN - NLM
STAT- MEDLINE
DCOM- 20130118
LR  - 20191210
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 12
IP  - 11
DP  - 2012
TI  - Shifting the emphasis to meaningful ethics engagement in the development of
      health policies.
PG  - 18-20
LID - 10.1080/15265161.2012.719265 [doi]
FAU - Kirby, Jeffrey
AU  - Kirby J
AD  - Dalhousie University, Department of Bioethics, 5849 University Avenue, Halifax,
      Nova Scotia, B3H 4H7, Canada. Jeffrey.Kirby@dal.ca
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2012;12(11):3-15. PMID: 23072671
MH  - Advertising/*ethics
MH  - Blood Transfusion/*ethics
MH  - *Ethics Committees, Clinical
MH  - *Ethics, Institutional
MH  - *Health Policy
MH  - Hospitals/*ethics
MH  - Humans
MH  - *Jehovah's Witnesses
MH  - Pediatrics/*ethics
MH  - *Quality Improvement
EDAT- 2012/10/18 06:00
MHDA- 2013/01/19 06:00
CRDT- 2012/10/18 06:00
PHST- 2012/10/18 06:00 [entrez]
PHST- 2012/10/18 06:00 [pubmed]
PHST- 2013/01/19 06:00 [medline]
AID - 10.1080/15265161.2012.719265 [doi]
PST - ppublish
SO  - Am J Bioeth. 2012;12(11):18-20. doi: 10.1080/15265161.2012.719265.


PMID- 23072672
OWN - NLM
STAT- MEDLINE
DCOM- 20130118
LR  - 20191210
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 12
IP  - 11
DP  - 2012
TI  - Thinking outside the black box: what policy theory can offer healthcare
      ethicists.
PG  - 16-8
LID - 10.1080/15265161.2012.721304 [doi]
FAU - Winsor, Shawn
AU  - Winsor S
AD  - Joint Centre for Bioethics, University of Toronto. shawn.winsor@utoronto.ca
FAU - Giacomini, Mita
AU  - Giacomini M
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2012;12(11):3-15. PMID: 23072671
MH  - Advertising/*ethics
MH  - Blood Transfusion/*ethics
MH  - *Ethics Committees, Clinical
MH  - *Ethics, Institutional
MH  - *Health Policy
MH  - Hospitals/*ethics
MH  - Humans
MH  - *Jehovah's Witnesses
MH  - Pediatrics/*ethics
MH  - *Quality Improvement
EDAT- 2012/10/18 06:00
MHDA- 2013/01/19 06:00
CRDT- 2012/10/18 06:00
PHST- 2012/10/18 06:00 [entrez]
PHST- 2012/10/18 06:00 [pubmed]
PHST- 2013/01/19 06:00 [medline]
AID - 10.1080/15265161.2012.721304 [doi]
PST - ppublish
SO  - Am J Bioeth. 2012;12(11):16-8. doi: 10.1080/15265161.2012.721304.


PMID- 23072671
OWN - NLM
STAT- MEDLINE
DCOM- 20130118
LR  - 20191210
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 12
IP  - 11
DP  - 2012
TI  - Opening the black box of ethics policy work: evaluating a covert practice.
PG  - 3-15
LID - 10.1080/15265161.2012.719263 [doi]
AB  - Hospital ethics committees (HECs) and ethicists generally describe themselves as 
      engaged in four domains of practice: case consultation, research, education, and 
      policy work. Despite the increasing attention to quality indicators, practice
      standards, and evaluation methods for the other domains, comparatively little is 
      known or published about the policy work of HECs or ethicists. This article
      attempts to open the "black box" of this health care ethics practice by providing
      two detailed case examples of ethics policy reviews. We also describe the
      development and application of an evaluation strategy to assess the quality of
      ethics policy review work, and to enable continuous improvement of ethics policy 
      review processes. Given the potential for policy work to impact entire patient
      populations and organizational systems, it is imperative that HECs and ethicists 
      develop clearer roles, responsibilities, procedural standards, and evaluation
      methods to ensure the delivery of consistent, relevant, and high-quality ethics
      policy reviews.
FAU - Frolic, Andrea
AU  - Frolic A
AD  - Faculty of Health Sciences McMaster University Medical Center, 1F9-1200 Main
      Street West, Hamilton, ON L8N 3Z5, Canada. frolic@hhsc.ca
FAU - Drolet, Katherine
AU  - Drolet K
FAU - Bryanton, Kim
AU  - Bryanton K
FAU - Caron, Carole
AU  - Caron C
FAU - Cupido, Cynthia
AU  - Cupido C
FAU - Flaherty, Barb
AU  - Flaherty B
FAU - Fung, Sylvia
AU  - Fung S
FAU - McCall, Lori
AU  - McCall L
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CIN - Am J Bioeth. 2012;12(11):16-8. PMID: 23072672
CIN - Am J Bioeth. 2012;12(11):18-20. PMID: 23072673
CIN - Am J Bioeth. 2012;12(11):20-2. PMID: 23072674
CIN - Am J Bioeth. 2012;12(11):23-4. PMID: 23072675
CIN - Am J Bioeth. 2012;12(11):25-7. PMID: 23072676
CIN - Am J Bioeth. 2012;12(11):27-9. PMID: 23072677
MH  - Advertising/*ethics
MH  - Blood Transfusion/*ethics
MH  - Ethicists
MH  - *Ethics Committees, Clinical
MH  - Ethics Consultation
MH  - *Ethics, Institutional
MH  - Guidelines as Topic
MH  - *Health Policy
MH  - Hospitals/*ethics/standards
MH  - Humans
MH  - *Jehovah's Witnesses
MH  - Pediatrics/*ethics
MH  - *Quality Improvement/trends
MH  - Surveys and Questionnaires
EDAT- 2012/10/18 06:00
MHDA- 2013/01/19 06:00
CRDT- 2012/10/18 06:00
PHST- 2012/10/18 06:00 [entrez]
PHST- 2012/10/18 06:00 [pubmed]
PHST- 2013/01/19 06:00 [medline]
AID - 10.1080/15265161.2012.719263 [doi]
PST - ppublish
SO  - Am J Bioeth. 2012;12(11):3-15. doi: 10.1080/15265161.2012.719263.


PMID- 23072670
OWN - NLM
STAT- MEDLINE
DCOM- 20130118
LR  - 20121017
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 12
IP  - 11
DP  - 2012
TI  - The instrumental role of hospital ethics committees in policy work.
PG  - 1-2
LID - 10.1080/15265161.2012.729935 [doi]
FAU - Garrison, Nanibaa' A
AU  - Garrison NA
FAU - Magnus, David
AU  - Magnus D
LA  - eng
PT  - Editorial
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
MH  - *Ethics Committees, Clinical
MH  - Ethics Consultation
MH  - *Ethics, Institutional
MH  - Guidelines as Topic
MH  - *Health Policy
MH  - Hospitals/*ethics/standards
MH  - Humans
MH  - Interdisciplinary Communication
MH  - *Quality Improvement/trends
MH  - United States
EDAT- 2012/10/18 06:00
MHDA- 2013/01/19 06:00
CRDT- 2012/10/18 06:00
PHST- 2012/10/18 06:00 [entrez]
PHST- 2012/10/18 06:00 [pubmed]
PHST- 2013/01/19 06:00 [medline]
AID - 10.1080/15265161.2012.729935 [doi]
PST - ppublish
SO  - Am J Bioeth. 2012;12(11):1-2. doi: 10.1080/15265161.2012.729935.


PMID- 23072635
OWN - NLM
STAT- MEDLINE
DCOM- 20131028
LR  - 20181202
IS  - 1365-2648 (Electronic)
IS  - 0309-2402 (Linking)
VI  - 69
IP  - 7
DP  - 2013 Jul
TI  - Effectiveness of advanced practice nursing interventions in older people:
      protocol for a systematic review and qualitative study.
PG  - 1652-9
LID - 10.1111/jan.12030 [doi]
AB  - AIMS: This protocol outlines a review and qualitative study to determine the
      models and effectiveness of Advanced Practice Nursing developed for the health
      care of people over 65 years in different settings (hospital care, home care,
      outpatients' care, and nursing homes) and to identify the ingredients of the
      interventions developed by Advanced Practice Nursing in the field of geriatric
      care. BACKGROUND: Numbers of nurses in advanced roles have increased
      internationally in conjunction with research to determine their effectiveness.
      Nevertheless, in older people, evidence of advanced practice roles remains
      scattered, and there is little synthesis of evidence, and therefore it is not
      easy to visualize the different practice models, their components, and their
      impact. DESIGN: Study protocol with two phases: a systematic review and a
      qualitative study. METHODS: First phase: Depending on comparability of studies,
      meta-analysis will be undertaken. If so, results will be summarized in relative
      and absolute measures or mean difference, depending on the type of outcome.
      Sensitivity and heterogeneity analyses will be performed. Second phase: a content
      analysis will be carried out of the interventions identified in the systematic
      review, and they will be contrasted with the contents of the Nursing
      Interventions Classification. Finally, this matching will be submitted to expert 
      consensus using a Delphi technique. Approval from the Ethics Committee was
      obtained in July 2010 and funding was obtained in March 2011. CONCLUSION: The
      identification of components of Advanced Practice Nursing models and evidence of 
      their effectiveness will contribute to designing more grounded nursing services
      for older people. Additionally, the categorization of Advanced Practice Nursing
      interventions through Nursing Interventions Classification would permit
      comparisons to be made between settings or between healthcare systems.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Morilla-Herrera, Juan Carlos
AU  - Morilla-Herrera JC
AD  - Director of the Home Nursing Unit and Primary Health Care District of Malaga;
      Faculty of Health Sciences, University of Malaga, Spain.
FAU - Morales-Asencio, Jose Miguel
AU  - Morales-Asencio JM
FAU - Martin-Santos, Francisco Javier
AU  - Martin-Santos FJ
FAU - Garcia-Mayor, Silvia
AU  - Garcia-Mayor S
FAU - Rodriguez-Bouza, Monica
AU  - Rodriguez-Bouza M
FAU - Gonzalez-Posadas, Fernando
AU  - Gonzalez-Posadas F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121017
PL  - England
TA  - J Adv Nurs
JT  - Journal of advanced nursing
JID - 7609811
SB  - IM
MH  - *Advanced Practice Nursing
MH  - Aged
MH  - Delphi Technique
MH  - *Geriatric Nursing
MH  - Humans
MH  - Meta-Analysis as Topic
MH  - *Nurse's Role
MH  - *Nursing Evaluation Research
MH  - Qualitative Research
MH  - *Research Design
MH  - Systematic Reviews as Topic
EDAT- 2012/10/18 06:00
MHDA- 2013/10/29 06:00
CRDT- 2012/10/18 06:00
PHST- 2012/09/08 00:00 [accepted]
PHST- 2012/10/18 06:00 [entrez]
PHST- 2012/10/18 06:00 [pubmed]
PHST- 2013/10/29 06:00 [medline]
AID - 10.1111/jan.12030 [doi]
PST - ppublish
SO  - J Adv Nurs. 2013 Jul;69(7):1652-9. doi: 10.1111/jan.12030. Epub 2012 Oct 17.


PMID- 23072321
OWN - NLM
STAT- MEDLINE
DCOM- 20130211
LR  - 20211021
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 13
DP  - 2012 Oct 16
TI  - Qualitative study of knowledge and attitudes to biobanking among lay persons in
      Nigeria.
PG  - 27
LID - 10.1186/1472-6939-13-27 [doi]
AB  - BACKGROUND: Interest in biobanking for collection of specimens for
      non-communicable diseases research has grown in recent times. This paper explores
      the perspectives of Nigerians on donation of specimen for the biobanking
      research. METHODS: We conducted 16 Focus Group Discussions (FGD) with individuals
      from different ethnic, age and socio-economic groups in Kano (North), Enugu
      (Southeast), Oyo States (Southwest) and Abuja, the Federal Capital Territory
      (Central) of Nigeria. We used topic guides and prompt statements to explore the
      knowledge and understanding of interviewees to general issues about biobanking of
      biospecimens, their use and specifically about role of biobanking in
      non-communicable diseases research. RESULTS: A total of 123 individuals
      participated in 16 focus group discussions in 2011. Our participants had limited 
      knowledge of the concept of biobanking but accepted it once they were educated
      about it and saw it as a worthwhile venture. Half of our study participants
      supported use of broad consent, a quarter supported restricted consent while the 
      remaining quarter were in favour of tiered consent. Most discussants support
      shipment of their samples to other countries for further research, but they
      prefer those collaborations to be done only with competent, ethical researchers
      and they would like to receive feedback about such projects. The majority
      preferred health care as a benefit from participation, particularly for any
      unexpected condition that may be discovered during the course of the research
      instead of financial compensation. Participants emphasized the need to ensure
      that donated samples were not used for research that contradicts their religious 
      beliefs. CONCLUSIONS: Our study demonstrates that our participants accepted
      biobanking once they understand it but there were different attitudes to elements
      of biobanking such as type of consent. Our study highlights the need to carefully
      document population attitudes to elements of modern scientific research and the
      consenting process.
FAU - Igbe, Michael A
AU  - Igbe MA
AD  - Department of Public Health, Federal Ministry of Health, 9th floor, Room 909,
      Federal Secretariat, Phase 3, Abuja, Nigeria. igbemichael@yahoo.com
FAU - Adebamowo, Clement A
AU  - Adebamowo CA
LA  - eng
GR  - D43 TW007091/TW/FIC NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20121016
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biological Specimen Banks/*ethics/standards/trends
MH  - Comprehension
MH  - Cultural Characteristics
MH  - Female
MH  - Focus Groups
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - *Informed Consent
MH  - Male
MH  - Middle Aged
MH  - *Moral Obligations
MH  - Nigeria
MH  - Qualitative Research
MH  - Religion
MH  - Research Personnel/*ethics
MH  - Tissue Banks/ethics
PMC - PMC3507723
EDAT- 2012/10/18 06:00
MHDA- 2013/02/12 06:00
CRDT- 2012/10/18 06:00
PHST- 2012/09/05 00:00 [received]
PHST- 2012/10/10 00:00 [accepted]
PHST- 2012/10/18 06:00 [entrez]
PHST- 2012/10/18 06:00 [pubmed]
PHST- 2013/02/12 06:00 [medline]
AID - 1472-6939-13-27 [pii]
AID - 10.1186/1472-6939-13-27 [doi]
PST - epublish
SO  - BMC Med Ethics. 2012 Oct 16;13:27. doi: 10.1186/1472-6939-13-27.


PMID- 23072191
OWN - NLM
STAT- MEDLINE
DCOM- 20121120
LR  - 20121017
IS  - 1015-8146 (Print)
IS  - 1015-8146 (Linking)
VI  - 23
IP  - 3
DP  - 2012
TI  - In search of the diagnosis, and the patient: transient galactosemia demystified
      after 14 years.
PG  - 415-21
AB  - Infantile galactosemia can be caused by inborn errors of galactose metabolism or 
      other rare causes like Fanconi-Bickel syndrome, congenital porto-systemic
      shunting and multiple hepatic arterio-venous malformations. All these disease
      entities are however not commonly seen. We report a case of transient infantile
      galactosemia who first presented in the 1990s, for which no underlying pathology 
      could be identified despite extensive investigations. The diagnosis had not been 
      apparent until after more than a decade, at that time the patient was lost to
      contact. Considering the potential diagnosis an important and significant one,
      efforts were made by the case pathologists and clinicians to search for the
      patient. Ethical dilemmas were encountered during the search of the patient,
      which involved issues of patient confidentiality and autonomy, and the doctors'
      duty-to-care. Modern biochemical and molecular testing confirmed the diagnosis
      after the patient was finally found. The case illustrates the power of molecular 
      testing to retrospectively diagnose an inherited metabolic disease when
      biochemical abnormalities have subsided, the value of an accurate and precise
      diagnosis, and the importance of appropriate genetic counselling in an apparently
      asymptomatic patient in the era of personalized medicine.
FAU - Lee, H C H
AU  - Lee HC
AD  - Department of Pathology, Princess Margaret Hospital, Hong Kong.
FAU - Lam, C W
AU  - Lam CW
FAU - Yuen, Y P
AU  - Yuen YP
FAU - Lai, C K
AU  - Lai CK
FAU - Chan, K Y
AU  - Chan KY
FAU - Chan, A Y W
AU  - Chan AY
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Genet Couns
JT  - Genetic counseling (Geneva, Switzerland)
JID - 9015261
SB  - IM
MH  - Adolescent
MH  - Galactosemias/diagnosis/*genetics
MH  - Genetic Counseling
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - Time Factors
EDAT- 2012/10/18 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/10/18 06:00
PHST- 2012/10/18 06:00 [entrez]
PHST- 2012/10/18 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
PST - ppublish
SO  - Genet Couns. 2012;23(3):415-21.


PMID- 23072040
OWN - NLM
STAT- MEDLINE
DCOM- 20121102
LR  - 20121017
IS  - 0193-7758 (Print)
IS  - 0193-7758 (Linking)
VI  - 34
IP  - 5
DP  - 2012 Sep-Oct
TI  - Confidentiality and electronic surveys: how IRBs address ethical and technical
      issues.
PG  - 8-15
FAU - Baker, Timothy D
AU  - Baker TD
AD  - St. Cloud State University, MN, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - IRB
JT  - IRB
JID - 7906878
SB  - IM
MH  - Computer Security/*ethics
MH  - Confidentiality/*ethics
MH  - Cross-Sectional Studies
MH  - Data Collection/*ethics
MH  - *Ethics Committees, Research
MH  - Humans
MH  - *Internet
MH  - *Organizational Policy
EDAT- 2012/10/18 06:00
MHDA- 2012/11/03 06:00
CRDT- 2012/10/18 06:00
PHST- 2012/10/18 06:00 [entrez]
PHST- 2012/10/18 06:00 [pubmed]
PHST- 2012/11/03 06:00 [medline]
PST - ppublish
SO  - IRB. 2012 Sep-Oct;34(5):8-15.


PMID- 23071532
OWN - NLM
STAT- MEDLINE
DCOM- 20130402
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 10
DP  - 2012
TI  - The geographical distribution of leadership in globalized clinical trials.
PG  - e45984
LID - 10.1371/journal.pone.0045984 [doi]
AB  - BACKGROUND: Pharmaceutical trials are mainly initiated by sponsors and
      investigators in the United States, Western Europe and Japan. However, more and
      more patients are enrolled in Central and Eastern Europe, Latin America and Asia.
      The involvement of patients in new geographical settings raises questions about
      scientific and ethical integrity, especially when experience with those settings 
      is lacking at the level of trial management. We therefore studied to what extent 
      the geographical shift in patient enrolment is anticipated in the composition of 
      trial management teams using the author nationalities on the primary outcome
      publication as an indicator of leadership. METHODS AND FINDINGS: We conducted a
      cohort-study among 1,445 registered trials in www.clinicaltrials.gov that could
      be matched with a primary outcome publication using clinical trial registry
      numbers listed in publications. The name of the sponsor and the enrolment
      countries were extracted from all registrations. The author-addresses of all
      authors were extracted from the publications. We searched the author-address of
      all publications to determine whether enrolment countries and sponsors listed on 
      registrations also appeared on a matched publication. Of all sponsors, 80.1% were
      listed with an author-address on the publication. Of all enrolment countries,
      50.3% appeared with an author-address on the publication. The listing of
      enrolment countries was especially low for industry-funded trials (39.9%) as
      compared to government (90.4%) and not-for-profit funding (93.7%). We found that 
      listing of enrolment countries in industry-funded trials was higher for
      traditional research locations such as the United States (98.2%) and Japan
      (72.0%) as compared to nontraditional research locations such as Poland (27.3%)
      and Mexico (14.1%). CONCLUSIONS: Despite patient enrolment efforts, the
      involvement of researchers from nontraditional locations in trial management as
      measured by their contribution to manuscript writing is modest. This division of 
      labor has significant implications for the scientific and ethical integrity of
      global clinical research.
FAU - Hoekman, Jarno
AU  - Hoekman J
AD  - Department of Clinical Pharmacology, University of Groningen, University Medical 
      Center Groningen, Groningen, The Netherlands. j.hoekman@umcg.nl
FAU - Frenken, Koen
AU  - Frenken K
FAU - de Zeeuw, Dick
AU  - de Zeeuw D
FAU - Heerspink, Hiddo Lambers
AU  - Heerspink HL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121010
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Authorship
MH  - Biomedical Research/*ethics/organization & administration
MH  - Clinical Trials as Topic/*standards
MH  - Humans
MH  - Internationality
MH  - Japan
MH  - *Leadership
MH  - Publishing
MH  - Registries
MH  - Research Support as Topic
MH  - United Kingdom
MH  - United States
PMC - PMC3468615
EDAT- 2012/10/17 06:00
MHDA- 2013/04/03 06:00
CRDT- 2012/10/17 06:00
PHST- 2012/04/18 00:00 [received]
PHST- 2012/08/27 00:00 [accepted]
PHST- 2012/10/17 06:00 [entrez]
PHST- 2012/10/17 06:00 [pubmed]
PHST- 2013/04/03 06:00 [medline]
AID - 10.1371/journal.pone.0045984 [doi]
AID - PONE-D-12-11533 [pii]
PST - ppublish
SO  - PLoS One. 2012;7(10):e45984. doi: 10.1371/journal.pone.0045984. Epub 2012 Oct 10.


PMID- 23071241
OWN - NLM
STAT- MEDLINE
DCOM- 20130306
LR  - 20181202
IS  - 1527-7755 (Electronic)
IS  - 0732-183X (Linking)
VI  - 30
IP  - 33
DP  - 2012 Nov 20
TI  - Palliative sedation: further evidence needs to be accompanied by ethical guidance
      to ensure professional practice at the end of life.
PG  - 4176; author reply 4177-8
LID - 10.1200/JCO.2012.44.2368 [doi]
FAU - Schildmann, Eva
AU  - Schildmann E
FAU - Vollmann, Jochen
AU  - Vollmann J
FAU - Schildmann, Jan
AU  - Schildmann J
LA  - eng
PT  - Letter
PT  - Comment
DEP - 20121015
PL  - United States
TA  - J Clin Oncol
JT  - Journal of clinical oncology : official journal of the American Society of
      Clinical Oncology
JID - 8309333
RN  - 0 (Hypnotics and Sedatives)
SB  - IM
CON - J Clin Oncol. 2012 Apr 20;30(12):1378-83. PMID: 22412129
MH  - Female
MH  - Humans
MH  - Hypnotics and Sedatives/*therapeutic use
MH  - Male
MH  - Neoplasms/*drug therapy/*mortality
MH  - Palliative Care/*methods
MH  - Terminal Care/*methods
EDAT- 2012/10/17 06:00
MHDA- 2013/03/07 06:00
CRDT- 2012/10/17 06:00
PHST- 2012/10/17 06:00 [entrez]
PHST- 2012/10/17 06:00 [pubmed]
PHST- 2013/03/07 06:00 [medline]
AID - JCO.2012.44.2368 [pii]
AID - 10.1200/JCO.2012.44.2368 [doi]
PST - ppublish
SO  - J Clin Oncol. 2012 Nov 20;30(33):4176; author reply 4177-8. doi:
      10.1200/JCO.2012.44.2368. Epub 2012 Oct 15.


PMID- 23071225
OWN - NLM
STAT- MEDLINE
DCOM- 20130506
LR  - 20211021
IS  - 1527-7755 (Electronic)
IS  - 0732-183X (Linking)
VI  - 30
IP  - 35
DP  - 2012 Dec 10
TI  - Communicating and understanding the purpose of pediatric phase I cancer trials.
PG  - 4367-72
LID - 10.1200/JCO.2012.42.3004 [doi]
AB  - PURPOSE: Quality informed consent should provide a clear understanding of the
      purpose of the research. Given the ethical challenges of pediatric phase I cancer
      trials, it is important to investigate physician-parent communication during
      informed consent conferences (ICCs) and parental understanding of the purpose of 
      these studies. METHODS: In the multisite Informed Consent in Pediatric Phase I
      Cancer Trials study, 85 ICCs for phase I research between June 2008 and May 2011 
      were directly observed, and 60 parents were subsequently interviewed. The
      scientific purpose was defined as composite understanding of drug safety, dose
      finding, and dose escalation. We determined the frequency with which physicians
      explained these and other phase I-related concepts during the ICC. Parent
      interviews were analyzed to determine understanding. RESULTS: The child was
      present at 83 of 85 ICCs. Only 32% of parents demonstrated substantial
      understanding of the scientific purpose of phase I cancer trials; 35%
      demonstrated little or no understanding. Parents of higher socioeconomic status
      and racial majority status were more likely to understand the scientific purpose.
      Factors associated with understanding included physician explanation of the goal 
      of the applicable phase I protocol offered (explained in 85% of ICCs) and
      explanation of the dose cohorts (explained in 43% of ICCs). Physicians explained 
      drug safety in 23% of ICCs, dose finding in 52% of ICCs, and dose escalation in
      53% of ICCs. CONCLUSION: Many parents of children participating in phase I trials
      do not understand the purpose of these trials. Physician-parent communication
      about the purpose of phase I research is lacking during ICCs.
FAU - Cousino, Melissa K
AU  - Cousino MK
AD  - Case Western Reserve University, Cleveland, OH, USA.
FAU - Zyzanski, Stephen J
AU  - Zyzanski SJ
FAU - Yamokoski, Amy D
AU  - Yamokoski AD
FAU - Hazen, Rebecca A
AU  - Hazen RA
FAU - Baker, Justin N
AU  - Baker JN
FAU - Noll, Robert B
AU  - Noll RB
FAU - Rheingold, Susan R
AU  - Rheingold SR
FAU - Geyer, J Russell
AU  - Geyer JR
FAU - Alexander, Stewart C
AU  - Alexander SC
FAU - Drotar, Dennis
AU  - Drotar D
FAU - Kodish, Eric D
AU  - Kodish ED
LA  - eng
GR  - P30 CA021765/CA/NCI NIH HHS/United States
GR  - R01 CA122217/CA/NCI NIH HHS/United States
GR  - R01CA122217/CA/NCI NIH HHS/United States
GR  - CA21765/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20121015
PL  - United States
TA  - J Clin Oncol
JT  - Journal of clinical oncology : official journal of the American Society of
      Clinical Oncology
JID - 8309333
SB  - IM
MH  - Adult
MH  - Aged
MH  - Child
MH  - Child, Preschool
MH  - Clinical Trials as Topic/ethics/*methods
MH  - *Communication
MH  - Female
MH  - Humans
MH  - Infant
MH  - *Informed Consent
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/*therapy
MH  - Parents/*psychology
MH  - Pediatrics/ethics/*methods
MH  - Physician-Patient Relations
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC3515769
EDAT- 2012/10/17 06:00
MHDA- 2013/05/07 06:00
CRDT- 2012/10/17 06:00
PHST- 2012/10/17 06:00 [entrez]
PHST- 2012/10/17 06:00 [pubmed]
PHST- 2013/05/07 06:00 [medline]
AID - JCO.2012.42.3004 [pii]
AID - 10.1200/JCO.2012.42.3004 [doi]
PST - ppublish
SO  - J Clin Oncol. 2012 Dec 10;30(35):4367-72. doi: 10.1200/JCO.2012.42.3004. Epub
      2012 Oct 15.


PMID- 23070959
OWN - NLM
STAT- MEDLINE
DCOM- 20130530
LR  - 20121220
IS  - 1098-2345 (Electronic)
IS  - 0275-2565 (Linking)
VI  - 75
IP  - 1
DP  - 2013 Jan
TI  - Reducing the ecological impact of field research.
PG  - 1-9
LID - 10.1002/ajp.22086 [doi]
AB  - Researchers and students at biological field stations, especially in remote
      areas, are subject to leaving "footprints," as we conduct research, work, and
      live in sensitive ecosystems. These footprints include travel, personal trash and
      waste, and field equipment (e.g. flagging, tree markers, plot markers, trail
      markers, monitoring devices, etc.). In this commentary, we argue that the field
      of primatology's commitment to minimum impact research should be more explicitly 
      and visibly integrated into our ethical protocols with regard to field research
      and instruction in sensitive environments. We review current ethical codes and
      potential solutions to reducing our "researcher footprints" while conducting
      fieldwork. Using Costa Rica as an example, we address how sustainable fieldwork
      differs among varying cultural contexts and argue that researchers should be made
      responsible and accountable for how our presence, research, and teaching might
      impact the environment. We conclude by recommending a set of guidelines to be
      added to ethical protocols regarding research design, station policies, and the
      conduct of research and teaching in the field.
CI  - (c) 2012 Wiley Periodicals, Inc.
FAU - Bezanson, Michelle
AU  - Bezanson M
AD  - Department of Anthropology, Santa Clara University, California, USA.
      mbezanson@scu.edu
FAU - Stowe, Rochelle
AU  - Stowe R
FAU - Watts, Sean M
AU  - Watts SM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121015
PL  - United States
TA  - Am J Primatol
JT  - American journal of primatology
JID - 8108949
SB  - IM
MH  - Animal Welfare
MH  - Animals
MH  - *Conservation of Natural Resources
MH  - Costa Rica
MH  - Ecology/*ethics
MH  - Ethology/*ethics
MH  - Guidelines as Topic
MH  - *Primates
MH  - Waste Management
EDAT- 2012/10/17 06:00
MHDA- 2013/06/01 06:00
CRDT- 2012/10/17 06:00
PHST- 2012/07/16 00:00 [received]
PHST- 2012/09/09 00:00 [revised]
PHST- 2012/09/09 00:00 [accepted]
PHST- 2012/10/17 06:00 [entrez]
PHST- 2012/10/17 06:00 [pubmed]
PHST- 2013/06/01 06:00 [medline]
AID - 10.1002/ajp.22086 [doi]
PST - ppublish
SO  - Am J Primatol. 2013 Jan;75(1):1-9. doi: 10.1002/ajp.22086. Epub 2012 Oct 15.


PMID- 23070886
OWN - NLM
STAT- MEDLINE
DCOM- 20130429
LR  - 20211021
IS  - 1572-8633 (Electronic)
IS  - 1386-7423 (Linking)
VI  - 15
IP  - 4
DP  - 2012 Nov
TI  - Is there a Mediterranean bioethics?
PG  - 419-29
LID - 10.1007/s11019-012-9443-3 [doi]
AB  - Is there a special Mediterranean approach to Bioethics and if so what are the
      roots of this approach? And why not a Bosphorus, or a 'lake Michigan' bioethics? 
      The answer to such a question depends on the focus one takes on defining
      'Mediterranean'? On the one hand one can refer to the Mediterranean region which 
      includes the surrounding coasts, having Europe on its northern coast line,
      northern Africa on its southern coast line (and these will include the north and 
      South West coasts), and in the Eastern region countries which border with
      Middle-Eastern countries. This approach is the approach currently being taken by 
      European Parliamentarians when they speak about the Mediterranean, namely
      including countries like France, Italy and Libya. On the other hand there is the 
      look upon the Mediterranean as 'Southern Europe'; this is a more 'traditional'
      way on how westerners view the Mediterranean. This common approach is often
      recognized when, for example, we speak of 'Mediterranean diet', or,
      'Mediterranean Temperament'. It would include Eastern countries like Greece and
      Cyprus. This article focuses on these two approaches to Mediterranean ethics
      after discussing issues pertaining to the region which are important to define in
      this context. It then analyses the need for having a Mediterranean approach to
      bioethical issues.
FAU - Mallia, Pierre
AU  - Mallia P
AD  - Bioethics Research Programme, Medical School, University of Malta, Msida, Malta. 
      bioethicscentre@onvol.net
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Med Health Care Philos
JT  - Medicine, health care, and philosophy
JID - 9815900
SB  - IM
MH  - Africa, Northern
MH  - Arab World
MH  - *Bioethical Issues
MH  - Bioethics/*trends
MH  - Catholicism
MH  - *Cultural Characteristics
MH  - Ethical Analysis
MH  - *Ethical Theory
MH  - Europe
MH  - European Union
MH  - Greek World
MH  - Humans
MH  - Islam
MH  - Judaism
MH  - Malta
MH  - Mediterranean Region
MH  - Middle East
MH  - Negotiating
MH  - Paternalism
MH  - Personal Autonomy
MH  - *Principle-Based Ethics
MH  - *Religion
MH  - Religion and Medicine
MH  - Roman World
MH  - Social Values
MH  - Theology
EDAT- 2012/10/17 06:00
MHDA- 2013/04/30 06:00
CRDT- 2012/10/17 06:00
PHST- 2012/10/17 06:00 [entrez]
PHST- 2012/10/17 06:00 [pubmed]
PHST- 2013/04/30 06:00 [medline]
AID - 10.1007/s11019-012-9443-3 [doi]
PST - ppublish
SO  - Med Health Care Philos. 2012 Nov;15(4):419-29. doi: 10.1007/s11019-012-9443-3.


PMID- 23070406
OWN - NLM
STAT- MEDLINE
DCOM- 20121130
LR  - 20121016
IS  - 1538-3644 (Electronic)
IS  - 0004-0010 (Linking)
VI  - 147
IP  - 10
DP  - 2012 Oct
TI  - Equipoise, ethics, and the necessity of randomized trials in surgery.
PG  - 899-900
LID - 10.1001/archsurg.2012.1796 [doi]
FAU - Adibe, Obinna O
AU  - Adibe OO
AD  - Division of Pediatric Surgery, Duke University Medical Center, Durham, North
      Carolina, USA.
FAU - St Peter, Shawn D
AU  - St Peter SD
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Arch Surg
JT  - Archives of surgery (Chicago, Ill. : 1960)
JID - 9716528
SB  - IM
MH  - Ethics, Research
MH  - Evidence-Based Medicine
MH  - Randomized Controlled Trials as Topic/*ethics
MH  - Specialties, Surgical/*ethics
MH  - *Therapeutic Equipoise
EDAT- 2012/10/17 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/10/17 06:00
PHST- 2012/10/17 06:00 [entrez]
PHST- 2012/10/17 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 1380435 [pii]
AID - 10.1001/archsurg.2012.1796 [doi]
PST - ppublish
SO  - Arch Surg. 2012 Oct;147(10):899-900. doi: 10.1001/archsurg.2012.1796.


PMID- 23070379
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140606
LR  - 20191112
IS  - 0104-5970 (Print)
IS  - 0104-5970 (Linking)
VI  - 19
IP  - 3
DP  - 2012 Sep
TI  - [Conflicts of interest in the research, production and dissemination of
      medicines].
PG  - 919-32
LID - S0104-59702012000300008 [pii]
AB  - This paper analyzes the debate about the ethical conflicts of the methods used by
      the pharmaceutical industry in the research, production and dissemination of
      medicines. Three aspects are examined: the involvement of medical professionals
      with representatives of the pharmaceutical industry; the conflicts of interest
      regarding their role as sponsors of scientific research; and the evaluation of
      drugs on human beings. It is seen that the message for health promotion comes
      from medicalization; the major pharmaceutical industries do not exclusively
      produce merchandise, but especially subjectivities. In this way, the type of
      order established by them is revealed.
FAU - Palma, Alexandre
AU  - Palma A
AD  - Programa de Pos-graduacao em Educacao Fisica, Universidade Federal do Rio de
      Janeiro, Rio de Janeiro, RJ, Brasil, 21941-599, palma_alexandre@yahoo.com.br.
FAU - Vilaca, Murilo Mariano
AU  - Vilaca MM
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Conflitos de interesse na pesquisa, producao e divulgacao de medicamentos.
PL  - Brazil
TA  - Hist Cienc Saude Manguinhos
JT  - Historia, ciencias, saude--Manguinhos
JID - 9513999
EDAT- 2012/10/17 06:00
MHDA- 2012/10/17 06:01
CRDT- 2012/10/17 06:00
PHST- 2010/08/01 00:00 [received]
PHST- 2011/09/01 00:00 [accepted]
PHST- 2012/10/17 06:00 [entrez]
PHST- 2012/10/17 06:00 [pubmed]
PHST- 2012/10/17 06:01 [medline]
AID - S0104-59702012000300008 [pii]
AID - 10.1590/s0104-59702012000300008 [doi]
PST - ppublish
SO  - Hist Cienc Saude Manguinhos. 2012 Sep;19(3):919-32. doi:
      10.1590/s0104-59702012000300008.


PMID- 23070338
OWN - NLM
STAT- MEDLINE
DCOM- 20130718
LR  - 20220629
IS  - 1980-5322 (Electronic)
IS  - 1807-5932 (Linking)
VI  - 67
IP  - 10
DP  - 2012 Oct
TI  - Fall-related traumas in urgent care centers.
PG  - 1133-8
LID - S1807-59322012001000003 [pii]
AB  - OBJECTIVE: To identify the scope and the characteristics of fall-related traumas 
      in urgent care centers in Sergipe, Brazil and to verify potential associations
      among the following variables: gender, age, and where the event occurred. METHOD:
      This descriptive, cross-sectional study with a quantitative approach was
      conducted in the urgent care centers of two public referral hospitals in the
      state of Sergipe, Brazil. The data collection was conducted in November 2010,
      after approval was obtained from the Human Research Ethics Committee, through a
      structured interview with a sample of 509 fall victims. RESULTS: Most of the
      participants were male, between 0 and 19 years old, single, with no impairments
      or preexisting diseases, nor regular use of medication or alcohol. The victims
      were brought to the hospital by ambulance and were accompanied. Most events
      occurred at home, were same-level falls, and most frequently resulted from
      slipping and tripping during recreational activities with a subsequent fracture, 
      contusion or sprain. Most victims were discharged from the hospital after care
      delivery. Statistically significant associations were found between place of fall
      and age and gender. CONCLUSION: There is a high incidence of seeking out care in 
      urgent care centers due to falls, which constitutes a severe public health
      problem that affects both genders in different age groups. The adoption of
      preventive measures aimed to reduce such events is urgently required.
FAU - Cartaxo, Carla Kalline Alves
AU  - Cartaxo CK
AD  - Nucleo de Pos-Graduacao em Medicina, Federal University of Sergipe, Aracaju/SE,
      Brazil.
FAU - Nunes, Mariangela da Silva
AU  - Nunes Mda S
FAU - Raposo, Oscar Felipe Falcao
AU  - Raposo OF
FAU - Fakhouri, Ricardo
AU  - Fakhouri R
FAU - Hora, Edilene Curvelo
AU  - Hora EC
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clinics (Sao Paulo)
JT  - Clinics (Sao Paulo, Brazil)
JID - 101244734
SB  - IM
MH  - Accidental Falls/*statistics & numerical data
MH  - Adolescent
MH  - Adult
MH  - Age Distribution
MH  - Age Factors
MH  - Ambulatory Care Facilities/*statistics & numerical data
MH  - Brazil/epidemiology
MH  - Chi-Square Distribution
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Sex Distribution
MH  - Socioeconomic Factors
MH  - Wounds and Injuries/*epidemiology
MH  - Young Adult
PMC - PMC3460014
EDAT- 2012/10/17 06:00
MHDA- 2013/07/19 06:00
CRDT- 2012/10/17 06:00
PHST- 2012/05/20 00:00 [received]
PHST- 2012/05/21 00:00 [accepted]
PHST- 2012/10/17 06:00 [entrez]
PHST- 2012/10/17 06:00 [pubmed]
PHST- 2013/07/19 06:00 [medline]
AID - S1807-5932(22)02213-X [pii]
AID - 10.6061/clinics/2012(10)03 [doi]
PST - ppublish
SO  - Clinics (Sao Paulo). 2012 Oct;67(10):1133-8. doi: 10.6061/clinics/2012(10)03.


PMID- 23070178
OWN - NLM
STAT- MEDLINE
DCOM- 20131119
LR  - 20220725
IS  - 1668-3501 (Electronic)
IS  - 0325-0075 (Linking)
VI  - 110
IP  - 5
DP  - 2012 Oct
TI  - [Association of dietary patterns and food allergy in infants during the first
      year of life].
PG  - 375-80
LID - 10.5546/aap.2012.eng.375 [doi]
AB  - INTRODUCTION: There is controversy about the effect of dietary patterns during
      the first year of life and the occurrence of food allergy. The objective of this 
      study was to evaluate the association between family history of allergy, allergic
      manifestations and dietary patterns during the first year of life in infants with
      and without food allergy. POPULATION AND METHODS: We performed a descriptive
      cross-sectional study in children under 2 years of age (n= 99), sorted in two
      groups: allergic group (n= 50) and control group (n= 49), matched by
      socioeconomic status, age and gender. Food allergy was deifned by internationally
      approved clinical criteria, prick and patch tests, and response to diet.
      Information on diet, clinical data and history of allergy in the parents were
      collected. The sample size was estimated for logistic regression (Freeman), and
      Student X(2) and Mann-Withney tests were used. The study and consent forms were
      approved by the Ethics Committee of the Institute of Nutrition and Food
      Technology (Instituto de Nutricion y Tecnologia de los Alimentos, INTA) and the
      Universidad de Chile. RESULTS: The allergic group showed a significantly higher
      prevalence (p <0.0001) of family history of allergy (84%) than the control group 
      (16%). Diarrhea was the symptom most frequently reported by the mothers of
      allergic infants during the first year of life. Bottle feeding was introduced
      earlier in the allergic group than in the control group (3 versus 6 months [p <
      0.03]); no differences regarding the start age for supplementary feeding was
      found. When performing logistic regression, only the family history of allergy
      was associated with a higher risk of food allergy (OR: 48.2; CI= 14.2-164; p <
      0.001). CONCLUSIONS: The early introduction of milk formula could promote the
      occurrence of food allergy in infants frequently presenting family history of
      allergy.
FAU - Bascunan Gamboa, Karla Amada
AU  - Bascunan Gamboa KA
AD  - Escuela de Nutricion y Dietetica, Facultad de Medicina, Universidad de Chile.
FAU - Weisstaub Nuta, Sergio Gerardo
AU  - Weisstaub Nuta SG
FAU - Chamorro Melo, Rodrigo Andres
AU  - Chamorro Melo RA
FAU - Guzman, Maria Antonieta
AU  - Guzman MA
FAU - Araya Quezada, Magdalena
AU  - Araya Quezada M
LA  - eng
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Asociacion entre los patrones alimentarios durante el primer ano de vida y
      alergia alimentaria en lactantes
PL  - Argentina
TA  - Arch Argent Pediatr
JT  - Archivos argentinos de pediatria
JID - 0372460
SB  - IM
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - *Diet
MH  - Female
MH  - Food Hypersensitivity/epidemiology/*etiology
MH  - Humans
MH  - Infant
MH  - Male
EDAT- 2012/10/17 06:00
MHDA- 2013/11/20 06:00
CRDT- 2012/10/17 06:00
PHST- 2011/11/14 00:00 [received]
PHST- 2012/04/27 00:00 [accepted]
PHST- 2012/10/17 06:00 [entrez]
PHST- 2012/10/17 06:00 [pubmed]
PHST- 2013/11/20 06:00 [medline]
AID - 10.5546/aap.2012.eng.375 [doi]
PST - ppublish
SO  - Arch Argent Pediatr. 2012 Oct;110(5):375-80. doi: 10.5546/aap.2012.eng.375.


PMID- 23070127
OWN - NLM
STAT- MEDLINE
DCOM- 20130423
LR  - 20131121
IS  - 1932-0620 (Print)
IS  - 1932-0620 (Linking)
VI  - 6
IP  - 4
DP  - 2012 Dec
TI  - Ethical and managerial considerations regarding state physician health programs.
PG  - 243-6
LID - 10.1097/ADM.0b013e318262ab09 [doi]
AB  - Many physicians are referred to state physician health programs (PHPs) for
      evaluation, monitoring, and treatment of mental health and substance use
      disorders. Most PHPs are "diversion" or "safe haven" programs, meaning that
      physicians who suffer from alcohol or drug problems can have their case diverted 
      to the PHP in lieu of being reported to the state licensing board. If the
      physician agrees to cooperate with the PHP and adhere to any recommendations it
      might make, the physician can avoid disciplinary action and remain in practice.
      These programs are therefore quite powerful and yet, to our knowledge, there has 
      not been any systematic scrutiny of the ethical and management issues that arise 
      in standard PHP practice. Given our 20 years of service as associate directors of
      one state PHP we analyze and evaluate the standard operating procedure of many
      PHPs and offer ethical critique as well as suggestions for improvement.
FAU - Boyd, J Wesley
AU  - Boyd JW
AD  - Department of Psychiatry, Harvard Medical School and Cambridge Health Alliance,
      and Boston Children's Hospital, Cambridge, MA, USA. jwboyd@cha.harvard.edu
FAU - Knight, John R
AU  - Knight JR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Addict Med
JT  - Journal of addiction medicine
JID - 101306759
RN  - 0 (Glucuronates)
RN  - 17685-04-0 (ethyl glucuronide)
RN  - 76I7G6D29C (Morphine)
SB  - IM
MH  - Alcoholism/*rehabilitation
MH  - Conflict of Interest/legislation & jurisprudence
MH  - *Ethics, Medical
MH  - Glucuronates/urine
MH  - Health Services Research/ethics/legislation & jurisprudence
MH  - Humans
MH  - Licensure, Medical/ethics/legislation & jurisprudence
MH  - Morphine/urine
MH  - *Physician Impairment/legislation & jurisprudence/psychology
MH  - Referral and Consultation/*ethics
MH  - State Health Plans/*ethics/legislation & jurisprudence/*organization &
      administration
MH  - Substance Abuse Detection/ethics/legislation & jurisprudence
MH  - Substance-Related Disorders/*rehabilitation
MH  - United States
EDAT- 2012/10/17 06:00
MHDA- 2013/04/24 06:00
CRDT- 2012/10/17 06:00
PHST- 2012/10/17 06:00 [entrez]
PHST- 2012/10/17 06:00 [pubmed]
PHST- 2013/04/24 06:00 [medline]
AID - 10.1097/ADM.0b013e318262ab09 [doi]
PST - ppublish
SO  - J Addict Med. 2012 Dec;6(4):243-6. doi: 10.1097/ADM.0b013e318262ab09.


PMID- 23069244
OWN - NLM
STAT- MEDLINE
DCOM- 20130403
LR  - 20181202
IS  - 1532-6586 (Electronic)
IS  - 0161-4754 (Linking)
VI  - 35
IP  - 7
DP  - 2012 Sep
TI  - Chiropractic care and public health: answering difficult questions about safety, 
      care through the lifespan, and community action.
PG  - 493-513
LID - 10.1016/j.jmpt.2012.09.001 [doi]
LID - S0161-4754(12)00152-2 [pii]
AB  - The purpose of this collaborative summary is to document current chiropractic
      involvement in the public health movement, reflect on social ecological levels of
      influence as a profession, and summarize the relationship of chiropractic to the 
      current public health topics of: safety, health issues through the lifespan, and 
      effective participation in community health issues. The questions that are
      addressed include: Is spinal manipulative therapy for neck and low-back pain a
      public health problem? What is the role of chiropractic care in prevention or
      reduction of musculoskeletal injuries in children? What ways can doctors of
      chiropractic stay updated on evidence-based information about vaccines and
      immunization throughout the lifespan? Can smoking cessation be a prevention
      strategy for back pain? Does chiropractic have relevance within the VA Health
      Care System for chronic pain and comorbid disorders? How can chiropractic use
      cognitive behavioral therapy to address chronic low back pain as a public health 
      problem? What opportunities exist for doctors of chiropractic to more effectively
      serve the aging population? What is the role of ethics and the contribution of
      the chiropractic profession to public health? What public health roles can
      chiropractic interns perform for underserved communities in a collaborative
      environment? Can the chiropractic profession contribute to community health? What
      opportunities do doctors of chiropractic have to be involved in health care
      reform in the areas of prevention and public health? What role do citizen-doctors
      of chiropractic have in organizing community action on health-related matters?
      How can our future chiropractic graduates become socially responsible agents of
      change?
CI  - Copyright (c) 2012 National University of Health Sciences. Published by Mosby,
      Inc. All rights reserved.
FAU - Johnson, Claire
AU  - Johnson C
FAU - Rubinstein, Sidney M
AU  - Rubinstein SM
FAU - Cote, Pierre
AU  - Cote P
FAU - Hestbaek, Lise
AU  - Hestbaek L
FAU - Injeyan, H Stephen
AU  - Injeyan HS
FAU - Puhl, Aaron
AU  - Puhl A
FAU - Green, Bart
AU  - Green B
FAU - Napuli, Jason G
AU  - Napuli JG
FAU - Dunn, Andrew S
AU  - Dunn AS
FAU - Dougherty, Paul
AU  - Dougherty P
FAU - Killinger, Lisa Zaynab
AU  - Killinger LZ
FAU - Page, Stacey A
AU  - Page SA
FAU - Stites, John S
AU  - Stites JS
FAU - Ramcharan, Michael
AU  - Ramcharan M
FAU - Leach, Robert A
AU  - Leach RA
FAU - Byrd, Lori D
AU  - Byrd LD
FAU - Redwood, Daniel
AU  - Redwood D
FAU - Kopansky-Giles, Deborah R
AU  - Kopansky-Giles DR
LA  - eng
PT  - Editorial
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Manipulative Physiol Ther
JT  - Journal of manipulative and physiological therapeutics
JID - 7807107
SB  - IM
MH  - Aged
MH  - Back Pain/prevention & control
MH  - Child
MH  - *Chiropractic/ethics
MH  - Chronic Disease
MH  - Cognitive Behavioral Therapy
MH  - Community Health Services
MH  - Community Participation
MH  - Evidence-Based Medicine
MH  - Health Care Reform
MH  - Humans
MH  - Low Back Pain/therapy
MH  - *Manipulation, Chiropractic
MH  - Manipulation, Spinal/adverse effects
MH  - Medically Underserved Area
MH  - Musculoskeletal System/injuries
MH  - Neck Pain/therapy
MH  - *Public Health
MH  - Smoking Cessation
MH  - Social Change
MH  - Social Responsibility
MH  - United States
MH  - United States Department of Veterans Affairs
MH  - Wounds and Injuries/therapy
EDAT- 2012/10/17 06:00
MHDA- 2013/04/04 06:00
CRDT- 2012/10/17 06:00
PHST- 2012/09/06 00:00 [received]
PHST- 2012/09/06 00:00 [accepted]
PHST- 2012/10/17 06:00 [entrez]
PHST- 2012/10/17 06:00 [pubmed]
PHST- 2013/04/04 06:00 [medline]
AID - S0161-4754(12)00152-2 [pii]
AID - 10.1016/j.jmpt.2012.09.001 [doi]
PST - ppublish
SO  - J Manipulative Physiol Ther. 2012 Sep;35(7):493-513. doi:
      10.1016/j.jmpt.2012.09.001.


PMID- 23067905
OWN - NLM
STAT- MEDLINE
DCOM- 20121217
LR  - 20220409
IS  - 1097-6744 (Electronic)
IS  - 0002-8703 (Linking)
VI  - 164
IP  - 4
DP  - 2012 Oct
TI  - Pediatric cardiovascular safety: challenges in drug and device development and
      clinical application.
PG  - 481-92
LID - 10.1016/j.ahj.2012.07.019 [doi]
LID - S0002-8703(12)00519-4 [pii]
AB  - Development of pediatric medications and devices is complicated by differences in
      pediatric physiology and pathophysiology (both compared with adults and within
      the pediatric age range), small patient populations, and practical and ethical
      challenges to designing clinical trials. This article summarizes the discussions 
      that occurred at a Cardiac Safety Research Consortium-sponsored Think Tank
      convened on December 10, 2010, where members from academia, industry, and
      regulatory agencies discussed important issues regarding pediatric cardiovascular
      safety of medications and cardiovascular devices. Pediatric drug and device
      development may use adult data but often requires additional preclinical and
      clinical testing to characterize effects on cardiac function and development.
      Challenges in preclinical trials include identifying appropriate animal models,
      clinically relevant efficacy end points, and methods to monitor cardiovascular
      safety. Pediatric clinical trials have different ethical concerns from adult
      trials, including consideration of the subjects' families. Clinical trial design 
      in pediatrics should assess risks and benefits as well as incorporate input from 
      families. Postmarketing surveillance, mandated by federal law, plays an important
      role in both drug and device safety assessment and becomes crucial in the
      pediatric population because of the limitations of premarketing pediatric
      studies. Solutions for this wide array of issues will require collaboration
      between academia, industry, and government as well as creativity in pediatric
      study design. Formation of various epidemiologic tools including registries to
      describe outcomes of pediatric cardiac disease and its treatment as well as
      cardiac effects of noncardiovascular medications, should inform preclinical and
      clinical development and improve benefit-risk assessments for the patients. The
      discussions in this article summarize areas of emerging consensus and other areas
      in which consensus remains elusive and provide suggestions for additional
      research to further our knowledge and understanding of this topic.
CI  - Copyright (c) 2012 Mosby, Inc. All rights reserved.
FAU - Bates, Katherine E
AU  - Bates KE
AD  - Children's Hospital of Philadelphia, Division of Cardiology, 3401 Civic Center
      Blvd., Philadelphia, PA 19104, USA. bateske1@email.chop.edu
FAU - Vetter, Victoria L
AU  - Vetter VL
FAU - Li, Jennifer S
AU  - Li JS
FAU - Cummins, Susan
AU  - Cummins S
FAU - Aguel, Fernando
AU  - Aguel F
FAU - Almond, Christopher
AU  - Almond C
FAU - Dubin, Anne M
AU  - Dubin AM
FAU - Elia, Josephine
AU  - Elia J
FAU - Finkle, John
AU  - Finkle J
FAU - Hausner, Elizabeth A
AU  - Hausner EA
FAU - Joseph, Francesca
AU  - Joseph F
FAU - Karkowsky, Abraham M
AU  - Karkowsky AM
FAU - Killeen, Matthew
AU  - Killeen M
FAU - Lemacks, Jodi
AU  - Lemacks J
FAU - Mathis, Lisa
AU  - Mathis L
FAU - McMahon, Ann W
AU  - McMahon AW
FAU - Pinnow, Ellen
AU  - Pinnow E
FAU - Rodriguez, Ignacio
AU  - Rodriguez I
FAU - Stockbridge, Norman L
AU  - Stockbridge NL
FAU - Stockwell, Margaret
AU  - Stockwell M
FAU - Tassinari, Melissa
AU  - Tassinari M
FAU - Krucoff, Mitchell W
AU  - Krucoff MW
LA  - eng
PT  - Consensus Development Conference
PT  - Journal Article
PL  - United States
TA  - Am Heart J
JT  - American heart journal
JID - 0370465
SB  - IM
MH  - Animals
MH  - Bioethical Issues
MH  - Cardiovascular Diseases/*therapy
MH  - Cardiovascular Surgical Procedures/*instrumentation
MH  - Child
MH  - Child Development/drug effects/*physiology
MH  - Clinical Trials as Topic/ethics
MH  - Device Approval/legislation & jurisprudence
MH  - Dose-Response Relationship, Drug
MH  - *Drug Design
MH  - Drug Evaluation, Preclinical
MH  - Electrocardiography
MH  - *Equipment Design
MH  - Government Regulation
MH  - Humans
MH  - Models, Animal
MH  - *Patient Safety/legislation & jurisprudence
MH  - Product Surveillance, Postmarketing
EDAT- 2012/10/17 06:00
MHDA- 2012/12/18 06:00
CRDT- 2012/10/17 06:00
PHST- 2012/07/20 00:00 [received]
PHST- 2012/07/20 00:00 [accepted]
PHST- 2012/10/17 06:00 [entrez]
PHST- 2012/10/17 06:00 [pubmed]
PHST- 2012/12/18 06:00 [medline]
AID - S0002-8703(12)00519-4 [pii]
AID - 10.1016/j.ahj.2012.07.019 [doi]
PST - ppublish
SO  - Am Heart J. 2012 Oct;164(4):481-92. doi: 10.1016/j.ahj.2012.07.019.


PMID- 23067131
OWN - NLM
STAT- MEDLINE
DCOM- 20151008
LR  - 20211021
IS  - 1369-7625 (Electronic)
IS  - 1369-6513 (Linking)
VI  - 18
IP  - 1
DP  - 2015 Feb
TI  - A patient perspective of pharmacist prescribing: 'crossing the
      specialisms-crossing the illnesses'.
PG  - 58-68
LID - 10.1111/hex.12008 [doi]
AB  - BACKGROUND: The drive for non-medical prescribing has progressed quickly since
      the late 1990s and involves a range of healthcare professionals including
      pharmacists. As part of a commissioned research project, this qualitative element
      of a larger case study focused on the views of patients of pharmacist
      prescribers. OBJECTIVE: The aim of this study was to explore patients'
      perspectives of pharmacists as prescribers. METHODS: Three pharmacists working as
      independent prescribers in the clinical areas of (i) hypertension, (ii)
      cardiovascular/diabetes management, (iii) anticoagulation were recruited to three
      case studies of pharmacist prescribing in Northern Ireland. One hundred and five 
      patients were invited to participate in focus groups after they had been
      prescribed for by the pharmacist. Focus groups took place between November 2010
      and March 2011 (ethical/governance approvals granted) were audio taped,
      transcribed verbatim, read independently by two authors and analysed using
      constant comparative analysis. RESULTS: Thirty-four patients agreed to
      participate across seven focus groups. Analysis revealed the emergence of one
      overarching theme: team approach to patient care. A number of subthemes related
      to the role of the pharmacist, the role of the doctor and patient benefits. There
      was an overwhelming lack of awareness of pharmacist prescribing. Patients
      discussed the importance of a multidisciplinary approach to their care and
      recognized limitations of the current model of prescribing. CONCLUSION: Patients 
      were positive about pharmacist prescribing and felt that a team approach to their
      care was the ideal model especially when treating those with more complex
      conditions. Despite positive attitudes, there was a general lack of awareness of 
      this new mode of practice.
CI  - (c) 2012 John Wiley & Sons Ltd.
FAU - McCann, Laura M
AU  - McCann LM
AD  - School of Pharmacy, Queen's University Belfast, Belfast, Northern Ireland.
FAU - Haughey, Sharon L
AU  - Haughey SL
FAU - Parsons, Carole
AU  - Parsons C
FAU - Lloyd, Fran
AU  - Lloyd F
FAU - Crealey, Grainne
AU  - Crealey G
FAU - Gormley, Gerard J
AU  - Gormley GJ
FAU - Hughes, Carmel M
AU  - Hughes CM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121015
PL  - England
TA  - Health Expect
JT  - Health expectations : an international journal of public participation in health 
      care and health policy
JID - 9815926
RN  - 0 (Anticoagulants)
RN  - 0 (Prescription Drugs)
SB  - IM
MH  - Adult
MH  - Anticoagulants/therapeutic use
MH  - Cardiovascular Diseases/drug therapy
MH  - Diabetes Mellitus/drug therapy
MH  - *Drug Prescriptions
MH  - Female
MH  - Focus Groups
MH  - Humans
MH  - Hypertension/drug therapy
MH  - Male
MH  - Northern Ireland
MH  - *Patient Satisfaction
MH  - Pharmacists/*psychology
MH  - *Prescription Drugs
MH  - *Professional-Patient Relations
MH  - Young Adult
PMC - PMC5060764
OTO - NOTNLM
OT  - Northern Ireland
OT  - focus groups
OT  - non-medical prescribing
OT  - patient perspective
OT  - pharmacist prescribing
OT  - qualitative methodology
EDAT- 2012/10/17 06:00
MHDA- 2015/10/09 06:00
CRDT- 2012/10/17 06:00
PHST- 2012/09/06 00:00 [accepted]
PHST- 2012/10/17 06:00 [entrez]
PHST- 2012/10/17 06:00 [pubmed]
PHST- 2015/10/09 06:00 [medline]
AID - 10.1111/hex.12008 [doi]
PST - ppublish
SO  - Health Expect. 2015 Feb;18(1):58-68. doi: 10.1111/hex.12008. Epub 2012 Oct 15.


PMID- 23067002
OWN - NLM
STAT- MEDLINE
DCOM- 20140430
LR  - 20181202
IS  - 1471-6712 (Electronic)
IS  - 0283-9318 (Linking)
VI  - 27
IP  - 4
DP  - 2013 Dec
TI  - Community nurses' experiences of ethical problems in end-of-life care in the
      patient's own home.
PG  - 831-8
LID - 10.1111/j.1471-6712.2012.01087.x [doi]
AB  - AIM: To gain a deeper understanding of community nurses' experiences of ethical
      problems in end-of-life care in the patient's own home. METHOD: Ten female nurses
      from five different communities with experience of end-of-life care were
      interviewed. A hermeneutic approach inspired by Gadamer was used to analyse the
      qualitative data from the interviews. FINDINGS: In the first step of
      interpretation, two themes emerged: Uncomfortable feelings and Lack of
      cooperation and in the second step, one theme Lack of security emerged. Finally, 
      the overall interpretation revealed the theme Feelings of loss of control in
      end-of-life care in the patient's own home. CONCLUSION: The nurses exhibited
      commitment and a desire to do good when caring for patients in the end-of-life
      phase, even if they sometimes experienced feelings of lack of control. This
      implies that, when confronted with care-related issues, they have the power to
      both act and react. This study aimed to increase understanding of ethical
      problems that arise in end-of-life care in the patient's own home and revealed
      the need to take the patients', relatives' and nurses' perspectives on health and
      suffering into consideration to ensure good end-of-life home care.
CI  - (c) 2012 The Authors Scandinavian Journal of Caring Sciences (c) 2012 Nordic
      College of Caring Science.
FAU - Karlsson, Margareta
AU  - Karlsson M
AD  - Department of Caring Science, Abo Academy University, Vasa, Finland; Department
      of Nursing, Health and Culture, University West, Trollhattan, Sweden.
FAU - Karlsson, Christina
AU  - Karlsson C
FAU - Barbosa da Silva, Antonio
AU  - Barbosa da Silva A
FAU - Berggren, Ingela
AU  - Berggren I
FAU - Soderlund, Maud
AU  - Soderlund M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121015
PL  - Sweden
TA  - Scand J Caring Sci
JT  - Scandinavian journal of caring sciences
JID - 8804206
MH  - *Community Health Nursing
MH  - *Home Care Services
MH  - Humans
MH  - Scandinavian and Nordic Countries
MH  - *Terminal Care
MH  - Workforce
OTO - NOTNLM
OT  - Gadamer
OT  - control
OT  - cooperation
OT  - end-of-life
OT  - ethical problem
OT  - hermeneutics
OT  - home care
OT  - nursing
OT  - security
EDAT- 2012/10/17 06:00
MHDA- 2014/05/03 06:00
CRDT- 2012/10/17 06:00
PHST- 2011/05/20 00:00 [received]
PHST- 2012/08/13 00:00 [accepted]
PHST- 2012/10/17 06:00 [entrez]
PHST- 2012/10/17 06:00 [pubmed]
PHST- 2014/05/03 06:00 [medline]
AID - 10.1111/j.1471-6712.2012.01087.x [doi]
PST - ppublish
SO  - Scand J Caring Sci. 2013 Dec;27(4):831-8. doi: 10.1111/j.1471-6712.2012.01087.x. 
      Epub 2012 Oct 15.


PMID- 23066513
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121016
LR  - 20220309
IS  - 2157-3999 (Electronic)
IS  - 2157-3999 (Linking)
VI  - 4
DP  - 2012 Mar 23
TI  - Utstein-style template for uniform data reporting of acute medical response in
      disasters.
PG  - e4f6cf3e8df15a
LID - 10.1371/4f6cf3e8df15a [doi]
AB  - BACKGROUND: In 2003, the Task Force on Quality Control of Disaster Management
      (WADEM) published guidelines for evaluation and research on health disaster
      management and recommended the development of a uniform data reporting tool.
      Standardized and complete reporting of data related to disaster medical response 
      activities will facilitate the interpretation of results, comparisons between
      medical response systems and quality improvement in the management of disaster
      victims. METHODS: Over a two-year period, a group of 16 experts in the fields of 
      research, education, ethics and operational aspects of disaster medical
      management from 8 countries carried out a consensus process based on a modified
      Delphi method and Utstein-style technique. RESULTS: The EMDM Academy Consensus
      Group produced an Utstein-style template for uniform data reporting of acute
      disaster medical response, including 15 data elements with indicators, that can
      be used for both research and quality improvement. CONCLUSION: It is anticipated 
      that the Utstein-style template will enable better and more accurate completion
      of reports on disaster medical response and contribute to further scientific
      evidence and knowledge related to disaster medical management in order to
      optimize medical response system interventions and to improve outcomes of
      disaster victims.
FAU - Debacker, Michel
AU  - Debacker M
AD  - Research Group on Emergency and Disaster Medicine, Vrije Universiteit Brussel,
      Belgium. Academy for Emergency Management and Disaster Medicine (EMDM Academy).
FAU - Hubloue, Ives
AU  - Hubloue I
FAU - Dhondt, Erwin
AU  - Dhondt E
FAU - Rockenschaub, Gerald
AU  - Rockenschaub G
FAU - Ruter, Anders
AU  - Ruter A
FAU - Codreanu, Tudor
AU  - Codreanu T
FAU - Koenig, Kristi L
AU  - Koenig KL
FAU - Schultz, Carl
AU  - Schultz C
FAU - Peleg, Kobi
AU  - Peleg K
FAU - Halpern, Pinchas
AU  - Halpern P
FAU - Stratton, Samuel
AU  - Stratton S
FAU - Della Corte, Francesco
AU  - Della Corte F
FAU - Delooz, Herman
AU  - Delooz H
FAU - Ingrassia, Pier Luigi
AU  - Ingrassia PL
FAU - Colombo, Davide
AU  - Colombo D
FAU - Castren, Maaret
AU  - Castren M
LA  - eng
PT  - Journal Article
DEP - 20120323
PL  - United States
TA  - PLoS Curr
JT  - PLoS currents
JID - 101515638
PMC - PMC3461975
EDAT- 2012/10/16 06:00
MHDA- 2012/10/16 06:01
CRDT- 2012/10/16 06:00
PHST- 2012/10/16 06:00 [entrez]
PHST- 2012/10/16 06:00 [pubmed]
PHST- 2012/10/16 06:01 [medline]
AID - 10.1371/4f6cf3e8df15a [doi]
PST - epublish
SO  - PLoS Curr. 2012 Mar 23;4:e4f6cf3e8df15a. doi: 10.1371/4f6cf3e8df15a.


PMID- 23066088
OWN - NLM
STAT- MEDLINE
DCOM- 20130802
LR  - 20130115
IS  - 1755-3245 (Electronic)
IS  - 0008-6363 (Linking)
VI  - 97
IP  - 2
DP  - 2013 Feb 1
TI  - Transplantation of parthenogenetic embryonic stem cells ameliorates cardiac
      dysfunction and remodelling after myocardial infarction.
PG  - 208-18
LID - 10.1093/cvr/cvs314 [doi]
AB  - AIMS: Parthenogenetic embryonic stem cells (pESCs) derived from artificially
      activated oocytes without fertilization presumably raise minimal ethical concerns
      and may serve as attractive candidates for regenerative medicine. Here we
      investigated whether pESCs could repair myocardial infarction (MI), in comparison
      to embryonic stem cells (ESCs). METHODS AND RESULTS: A total of 89 mice that
      survived coronary artery ligation randomly received an intramyocardial injection 
      of undifferentiated pESCs, ESCs, or saline. Sham-operated mice (n = 21) that
      received no treatment served as control animals. After 7 days, transplantation of
      pESCs increased expression of pro-angiogenic factors and reduced leucocyte
      infiltration. By 14 and 30 days post-MI, similar to treatment with ESCs,
      treatment with pESCs efficiently prevented cardiac remodelling and enhanced
      angiogenesis, in contrast to saline-treated hearts. Improved heart contractile
      function was also notable 30 days following transplantation of pESCs.
      Immunofluorescence staining revealed that tissues regenerated from pESCs in the
      infarcted myocardium were positive for markers of cardiomyocytes, endothelial
      cells, and smooth muscle cells. Unlike ESC-treated mice, which exhibited a high
      incidence of teratoma (6 of 34), the pESC-treated mice showed no teratomas (0 of 
      30) 30 days following transplantation. CONCLUSION: Transplantation of pESCs could
      attenuate cardiac dysfunction and adverse ventricular remodelling post-MI,
      suggesting that pESCs may provide promising therapeutic sources for MI in
      females.
FAU - Liu, Yi
AU  - Liu Y
AD  - State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive
      Materials, Ministry of Education, Nankai University, Tianjin, PR 300071, China.
FAU - Ye, Xiaoying
AU  - Ye X
FAU - Mao, Lina
AU  - Mao L
FAU - Cheng, Zhaokang
AU  - Cheng Z
FAU - Yao, Xinpeng
AU  - Yao X
FAU - Jia, Xiaohua
AU  - Jia X
FAU - Mao, Duo
AU  - Mao D
FAU - Ou, Lailiang
AU  - Ou L
FAU - Li, Zongjin
AU  - Li Z
FAU - Che, Yongzhe
AU  - Che Y
FAU - Liu, Na
AU  - Liu N
FAU - Steinhoff, Gustav
AU  - Steinhoff G
FAU - Liu, Lin
AU  - Liu L
FAU - Kong, Deling
AU  - Kong D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121012
PL  - England
TA  - Cardiovasc Res
JT  - Cardiovascular research
JID - 0077427
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Animals
MH  - Cell Differentiation
MH  - Collagen/metabolism
MH  - Embryonic Stem Cells/*transplantation
MH  - Female
MH  - Leukocytes/physiology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Mice, Inbred C57BL
MH  - Myocardial Infarction/physiopathology/*therapy
MH  - Parthenogenesis
MH  - Ventricular Function, Left
MH  - *Ventricular Remodeling
EDAT- 2012/10/16 06:00
MHDA- 2013/08/03 06:00
CRDT- 2012/10/16 06:00
PHST- 2012/10/16 06:00 [entrez]
PHST- 2012/10/16 06:00 [pubmed]
PHST- 2013/08/03 06:00 [medline]
AID - cvs314 [pii]
AID - 10.1093/cvr/cvs314 [doi]
PST - ppublish
SO  - Cardiovasc Res. 2013 Feb 1;97(2):208-18. doi: 10.1093/cvr/cvs314. Epub 2012 Oct
      12.


PMID- 23065541
OWN - NLM
STAT- MEDLINE
DCOM- 20140122
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 3
DP  - 2013 Sep
TI  - Teaching engineering ethics using BLOCKS game.
PG  - 1357-73
LID - 10.1007/s11948-012-9406-3 [doi]
AB  - The aim of this study was to investigate the use of a newly developed design game
      called BLOCKS to stimulate awareness of ethical responsibilities amongst
      engineering students. The design game was played by seventeen teams of chemical
      engineering students, with each team having to arrange pieces of colored paper to
      produce two letters each. Before the end of the game, additional constraints were
      introduced to the teams such that they faced similar ambiguity in the technical
      facts that the engineers involved in the Challenger disaster had faced prior to
      the space shuttle launch. At this stage, the teams had to decide whether to
      continue with their original design or to develop alternative solutions. After
      the teams had made their decisions, a video of the Challenger explosion was shown
      followed by a post-game discussion. The students' opinion on five Statements on
      ethics was tracked via a Five-Item Likert survey which was administered three
      times, before and after the ethical scenario was introduced, and after the video 
      and post-game discussion. The results from this study indicated that the
      combination of the game and the real-life incident from the video had generally
      strengthened the students' opinions of the Statements.
FAU - Lau, Shiew Wei
AU  - Lau SW
AD  - School of Engineering and Science, Curtin University Sarawak Malaysia, Sarawak,
      Malaysia. lau.shiew.wei@curtin.edu.my
FAU - Tan, Terence Peng Lian
AU  - Tan TP
FAU - Goh, Suk Meng
AU  - Goh SM
LA  - eng
PT  - Journal Article
DEP - 20121013
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Attitude
MH  - Awareness/*ethics
MH  - Chemical Engineering
MH  - Curriculum
MH  - Data Collection
MH  - Decision Making/*ethics
MH  - Disasters
MH  - Engineering/*education/ethics
MH  - Ethics, Professional/*education
MH  - Ethics, Research/education
MH  - Group Processes
MH  - Humans
MH  - *Social Responsibility
MH  - Students
MH  - Teaching/*methods
MH  - Uncertainty
EDAT- 2012/10/16 06:00
MHDA- 2014/01/23 06:00
CRDT- 2012/10/16 06:00
PHST- 2012/05/13 00:00 [received]
PHST- 2012/10/05 00:00 [accepted]
PHST- 2012/10/16 06:00 [entrez]
PHST- 2012/10/16 06:00 [pubmed]
PHST- 2014/01/23 06:00 [medline]
AID - 10.1007/s11948-012-9406-3 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Sep;19(3):1357-73. doi: 10.1007/s11948-012-9406-3. Epub 2012
      Oct 13.


PMID- 23065540
OWN - NLM
STAT- MEDLINE
DCOM- 20140122
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 3
DP  - 2013 Sep
TI  - Positive organizational outcomes associated with a penchant for openness.
PG  - 799-812
LID - 10.1007/s11948-012-9404-5 [doi]
AB  - The tension between scientific openness versus secrecy has existed for centuries 
      (Hull 1985). However, both academics and practitioners have recently argued that 
      openness by private firms has many positive attributes. The purpose of this
      research effort is to review the extant literature on openness and to develop
      hypotheses regarding its impact on organizational outcomes. We then use a unique 
      database to test the idea with 87 companies. Our findings are that openness is
      beneficial to the firm from a science, technological, and financial perspective
      and, perhaps, to the employees from an ethical viewpoint. The managerial and
      societal implications are also discussed.
FAU - McMillan, G Steven
AU  - McMillan GS
AD  - Penn State Abington, Abington, PA 19001, USA. gsm5@psu.edu
FAU - Casey, Debra L
AU  - Casey DL
LA  - eng
PT  - Journal Article
DEP - 20121013
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Confidentiality
MH  - Employment
MH  - Humans
MH  - *Organizations
MH  - *Private Sector
MH  - Science
MH  - Technology
EDAT- 2012/10/16 06:00
MHDA- 2014/01/23 06:00
CRDT- 2012/10/16 06:00
PHST- 2012/06/23 00:00 [received]
PHST- 2012/10/05 00:00 [accepted]
PHST- 2012/10/16 06:00 [entrez]
PHST- 2012/10/16 06:00 [pubmed]
PHST- 2014/01/23 06:00 [medline]
AID - 10.1007/s11948-012-9404-5 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Sep;19(3):799-812. doi: 10.1007/s11948-012-9404-5. Epub 2012
      Oct 13.


PMID- 23065539
OWN - NLM
STAT- MEDLINE
DCOM- 20140122
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 3
DP  - 2013 Sep
TI  - Incidental finding of tumor while investigating subarachnoid hemorrhage: ethical 
      considerations and practical strategies.
PG  - 1107-20
LID - 10.1007/s11948-012-9403-6 [doi]
AB  - High-resolution neuroimaging modalities are used often in studies involving
      healthy volunteers. Subsequently, a significant increase in the incidental
      discovery of asymptomatic intracranial abnormalities raised the important ethical
      issues of when follow-up and treatment may be necessary. We examined the
      literature to establish a practical set of criteria for approaching incidental
      findings. Our objective is to develop an algorithm for when follow-up may be
      important and to provide recommendations that would increase the likelihood of
      follow-up. A systematic literature search was performed using the PubMed and
      MEDLINE databases to identify articles describing brain tumors and intracranial
      aneurysms. The treatment algorithm we present suggests that incidental
      intracranial masses suspicious for glioma should be biopsied or resected, while
      other masses are to be followed with serial imaging based on the expected growth 
      pattern. Lack of follow-up can result in adverse outcomes that can be mitigated
      by using technology to facilitate communication and improve follow-up care. The
      importance of training physicians to be good communicators is also stressed. New 
      technology including automated telephone systems, texting and email will improve 
      access to patients and hopefully encourage compliance and follow-up.
FAU - Drazin, Doniel
AU  - Drazin D
AD  - Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048,
      USA. ddrazin@gmail.com
FAU - Spitler, Kevin
AU  - Spitler K
FAU - Cekic, Milos
AU  - Cekic M
FAU - Patel, Ashish
AU  - Patel A
FAU - Hanna, George
AU  - Hanna G
FAU - Shirzadi, Ali
AU  - Shirzadi A
FAU - Chu, Ray
AU  - Chu R
LA  - eng
PT  - Journal Article
DEP - 20121013
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Algorithms
MH  - Biopsy
MH  - Brain Neoplasms/*diagnosis/therapy
MH  - Glioma/*diagnosis/therapy
MH  - *Healthy Volunteers
MH  - Humans
MH  - *Incidental Findings
MH  - Neuroimaging/*ethics
MH  - *Practice Guidelines as Topic
MH  - *Subarachnoid Hemorrhage
EDAT- 2012/10/16 06:00
MHDA- 2014/01/23 06:00
CRDT- 2012/10/16 06:00
PHST- 2012/04/02 00:00 [received]
PHST- 2012/10/05 00:00 [accepted]
PHST- 2012/10/16 06:00 [entrez]
PHST- 2012/10/16 06:00 [pubmed]
PHST- 2014/01/23 06:00 [medline]
AID - 10.1007/s11948-012-9403-6 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Sep;19(3):1107-20. doi: 10.1007/s11948-012-9403-6. Epub 2012
      Oct 13.


PMID- 23065538
OWN - NLM
STAT- MEDLINE
DCOM- 20140122
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 3
DP  - 2013 Sep
TI  - Effects of alternative outcome scenarios and structured outcome evaluation on
      case-based ethics instruction.
PG  - 1283-303
LID - 10.1007/s11948-012-9402-7 [doi]
AB  - Case-based instruction has been regarded by many as a viable alternative to
      traditional lecture-based education and training. However, little is known about 
      how case-based training techniques impact training effectiveness. This study
      examined the effects of two such techniques: (a) presentation of alternative
      outcome scenarios to a case, and (b) conducting a structured outcome evaluation. 
      Consistent with the hypotheses, results indicate that presentation of alternative
      outcome scenarios reduced knowledge acquisition, reduced sensemaking and ethical 
      decision-making strategy use, and reduced decision ethicality. Conducting a
      structured outcome evaluation had no impact on these outcomes. Results indicate
      that those who use case-based instruction should take care to use clear, less
      complex cases with only a singular outcome if they are seeking these types of
      outcomes.
FAU - Peacock, Juandre
AU  - Peacock J
AD  - Department of Psychology, University of Oklahoma, Norman, OK 73072, USA.
      jpeacock@ou.edu
FAU - Harkrider, Lauren N
AU  - Harkrider LN
FAU - Bagdasarov, Zhanna
AU  - Bagdasarov Z
FAU - Connelly, Shane
AU  - Connelly S
FAU - Johnson, James F
AU  - Johnson JF
FAU - Thiel, Chase E
AU  - Thiel CE
FAU - Macdougall, Alexandra E
AU  - Macdougall AE
FAU - Mumford, Michael D
AU  - Mumford MD
FAU - Devenport, Lynn D
AU  - Devenport LD
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20121013
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Adult
MH  - Curriculum
MH  - Decision Making/*ethics
MH  - Ethics, Professional/*education
MH  - Ethics, Research/*education
MH  - Female
MH  - Humans
MH  - Male
MH  - Problem-Based Learning/*methods/standards
MH  - Teaching/*methods
MH  - Young Adult
EDAT- 2012/10/16 06:00
MHDA- 2014/01/23 06:00
CRDT- 2012/10/16 06:00
PHST- 2012/07/16 00:00 [received]
PHST- 2012/10/03 00:00 [accepted]
PHST- 2012/10/16 06:00 [entrez]
PHST- 2012/10/16 06:00 [pubmed]
PHST- 2014/01/23 06:00 [medline]
AID - 10.1007/s11948-012-9402-7 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Sep;19(3):1283-303. doi: 10.1007/s11948-012-9402-7. Epub
      2012 Oct 13.


PMID- 23065537
OWN - NLM
STAT- MEDLINE
DCOM- 20140122
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 3
DP  - 2013 Sep
TI  - Reverence and ethics in science.
PG  - 745-56
LID - 10.1007/s11948-012-9397-0 [doi]
AB  - Codes of ethics abound in science, but the question of why such codes should be
      obeyed is rarely asked. Various reasons for obeying a professional code have been
      proposed, but all are unsatisfactory in that they do not really motivate
      behavior. This article suggests that the long forgotten virtue of reverence
      provides both a reason to obey a professional code and motivation to do so. In
      addition, it discusses the importance of reverence as a cardinal virtue for
      scientists drawing on the ideas of Paul Woodruff on the role of virtue in
      community.
FAU - Kovac, Jeffrey
AU  - Kovac J
AD  - Department of Chemistry, University of Tennessee, Knoxville, TN 37996-1600, USA. 
      jkovac@utk.edu
LA  - eng
PT  - Journal Article
DEP - 20121013
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Codes of Ethics
MH  - Humans
MH  - *Motivation
MH  - Science/*ethics
MH  - *Social Values
MH  - *Virtues
EDAT- 2012/10/16 06:00
MHDA- 2014/01/23 06:00
CRDT- 2012/10/16 06:00
PHST- 2012/06/08 00:00 [received]
PHST- 2012/08/20 00:00 [accepted]
PHST- 2012/10/16 06:00 [entrez]
PHST- 2012/10/16 06:00 [pubmed]
PHST- 2014/01/23 06:00 [medline]
AID - 10.1007/s11948-012-9397-0 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Sep;19(3):745-56. doi: 10.1007/s11948-012-9397-0. Epub 2012 
      Oct 13.


PMID- 23065494
OWN - NLM
STAT- MEDLINE
DCOM- 20140716
LR  - 20130820
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 9
DP  - 2013 Sep
TI  - 'In a twilight world'? Judging the value of life for the minimally conscious
      patient.
PG  - 565-9
LID - 10.1136/medethics-2012-101028 [doi]
AB  - The recent ruling from England on the case of M is one of very few worldwide to
      consider whether life-sustaining treatment, in the form of clinically assisted
      nutrition and hydration, should continue to be provided to a patient in a
      minimally conscious state. Formally concerned with the English law pertaining to 
      precedent autonomy (specifically advance decision-making) and the best interests 
      of the incapacitated patient, the judgment issued in M's case implicitly engages 
      with three different accounts of the value of human life, which respectively
      emphasise its self-determined, intrinsic and instrumental value. The judge
      appeared to be most persuaded by the intrinsic value of life and he concluded
      that treatment ought to continue. Assessing whether his approach or conclusion
      were ethically appropriate involves significant substantive and evidential
      questions regarding where the burden of proof should lie and what standard of
      proof should be required when decisions are to be made about the fates of
      patients inhabiting 'twilight worlds'.
FAU - Huxtable, Richard
AU  - Huxtable R
AD  - Centre for Ethics in Medicine, School of Social and Community Medicine,
      University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UK.
      R.Huxtable@bristol.ac.uk
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121012
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Adult
MH  - Decision Making
MH  - Female
MH  - Humans
MH  - Morals
MH  - *Persistent Vegetative State
MH  - Personal Autonomy
MH  - *Value of Life
MH  - Withholding Treatment/*ethics/legislation & jurisprudence
OTO - NOTNLM
OT  - Capacity
OT  - Competence/incompetence
OT  - Law
OT  - Living Wills/Advance Directives
OT  - Neuroethics
EDAT- 2012/10/16 06:00
MHDA- 2014/07/17 06:00
CRDT- 2012/10/16 06:00
PHST- 2012/10/16 06:00 [entrez]
PHST- 2012/10/16 06:00 [pubmed]
PHST- 2014/07/17 06:00 [medline]
AID - medethics-2012-101028 [pii]
AID - 10.1136/medethics-2012-101028 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Sep;39(9):565-9. doi: 10.1136/medethics-2012-101028. Epub 2012
      Oct 12.


PMID- 23065493
OWN - NLM
STAT- MEDLINE
DCOM- 20130304
LR  - 20121218
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 1
DP  - 2013 Jan
TI  - Consent in dentistry: ethical and deontological issues.
PG  - 59-61
LID - 10.1136/medethics-2012-100850 [doi]
AB  - In Italy, consent for health treatment, aside from being an ethical and
      deontological obligation, constitutes an essential requirement for any medical
      treatment according to articles 13 and 32 of the National Constitution and also
      in accordance with the Council of Europe's 'Convention on Human Rights and
      Biomedicine'. An essential requirement for the validity of consent is that clear,
      exhaustive and adequate information be provided to the patient himself: the
      practice of informed consent is a communicative relationship in which the patient
      can express doubts, perplexities and clarification requests to the dentist.
      Furthermore, dental treatment has specific peculiarities: the relationship
      between dentistry and aesthetics, the concomitant presence of pathologies
      requiring different treatments, the elongated care process and the establishment 
      of a trustworthy relationship and familiarity with the patient represent
      important aspects in the configuration of the dentist-patient relationship and in
      the process of acquiring informed consent. The dentist must offer correct
      information on diagnosis, prognosis, the therapeutic perspective and the likely
      consequences of therapy, alternative therapy and refusal of therapy, as well as
      eventual commitments for the period after treatment. Particular consideration
      must be given to minors and patients of unsound mind: the dentist's approach to
      these patients needs to be clear and appropriate to the person's age and
      understanding ability, even if the decisional power for sanitary treatment may be
      in the hands of a third person.
FAU - Conti, Adelaide
AU  - Conti A
AD  - Forensic Science Department, University of Brescia, Centre of Bioethics Research 
      (with contribution of Fondazione Poliambulanza), Brescia, Italy.
FAU - Delbon, Paola
AU  - Delbon P
FAU - Laffranchi, Laura
AU  - Laffranchi L
FAU - Paganelli, Corrado
AU  - Paganelli C
LA  - eng
PT  - Journal Article
DEP - 20121012
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Decision Making
MH  - Dental Care/*ethics
MH  - Dentist-Patient Relations/*ethics
MH  - Disclosure/*ethics
MH  - Europe
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Italy
MH  - *Personal Autonomy
MH  - Trust
EDAT- 2012/10/16 06:00
MHDA- 2013/03/05 06:00
CRDT- 2012/10/16 06:00
PHST- 2012/10/16 06:00 [entrez]
PHST- 2012/10/16 06:00 [pubmed]
PHST- 2013/03/05 06:00 [medline]
AID - medethics-2012-100850 [pii]
AID - 10.1136/medethics-2012-100850 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Jan;39(1):59-61. doi: 10.1136/medethics-2012-100850. Epub 2012
      Oct 12.


PMID- 23065491
OWN - NLM
STAT- MEDLINE
DCOM- 20130304
LR  - 20220408
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 1
DP  - 2013 Jan
TI  - Perceived comfort level of medical students and residents in handling clinical
      ethics issues.
PG  - 55-8
LID - 10.1136/medethics-2011-100300 [doi]
AB  - BACKGROUND: Studies have shown that medical students and residents believe that
      their ethics preparation has been inadequate for handling ethical conflicts. The 
      objective of this study was to determine the self-perceived comfort level of
      medical students and residents in confronting clinical ethics issues. METHODS:
      Clinical medical students and residents at the University of Maryland School of
      Medicine completed a web-based survey between September 2009 and February 2010.
      The survey consisted of a demographic section, questions regarding the
      respondents' sense of comfort in handling a variety of clinical ethics issues,
      and a set of knowledge-type questions in ethics. RESULTS: Survey respondents
      included 129 medical students (response rate of 40.7%) and 207 residents
      (response rate of 52.7%). There were only a few clinical ethics issues with which
      more than 70% of the respondents felt comfortable in addressing. Only a slight
      majority (60.8%) felt prepared, in general, to handle clinical situations
      involving ethics issues, and only 44.1% and 53.2% agreed that medical school and 
      residency training, respectively, helped prepare them to handle such issues.
      Prior ethics training was not associated with these responses, but there was an
      association between the level of training (medical students vs residents) and the
      comfort level with many of the clinical ethics issues. CONCLUSIONS: Medical
      educators should include ethics educational methods within the context of
      real-time exposure to medical ethics dilemmas experienced by
      physicians-in-training.
FAU - Silverman, Henry J
AU  - Silverman HJ
AD  - Department of Medicine, University of Maryland, Baltimore, MD 21201, USA.
      hsilverm@medicine.umaryland.edu
FAU - Dagenais, Julien
AU  - Dagenais J
FAU - Gordon-Lipkin, Eliza
AU  - Gordon-Lipkin E
FAU - Caputo, Laura
AU  - Caputo L
FAU - Christian, Matthew W
AU  - Christian MW
FAU - Maidment, Bert W 3rd
AU  - Maidment BW 3rd
FAU - Binstock, Anna
AU  - Binstock A
FAU - Oyalowo, Akinbowale
AU  - Oyalowo A
FAU - Moni, Malini
AU  - Moni M
LA  - eng
PT  - Journal Article
DEP - 20121012
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Adult
MH  - *Bioethical Issues
MH  - Confounding Factors, Epidemiologic
MH  - Cross-Sectional Studies
MH  - Curriculum/standards
MH  - *Ethics, Medical
MH  - Female
MH  - Humans
MH  - Internship and Residency/ethics/methods/standards/*statistics & numerical data
MH  - Male
MH  - Maryland
MH  - Physician-Patient Relations/ethics
MH  - *Social Perception
MH  - Students, Medical/psychology/*statistics & numerical data
MH  - Surveys and Questionnaires
EDAT- 2012/10/16 06:00
MHDA- 2013/03/05 06:00
CRDT- 2012/10/16 06:00
PHST- 2012/10/16 06:00 [entrez]
PHST- 2012/10/16 06:00 [pubmed]
PHST- 2013/03/05 06:00 [medline]
AID - medethics-2011-100300 [pii]
AID - 10.1136/medethics-2011-100300 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Jan;39(1):55-8. doi: 10.1136/medethics-2011-100300. Epub 2012 
      Oct 12.


PMID- 23065318
OWN - NLM
STAT- MEDLINE
DCOM- 20130402
LR  - 20151119
IS  - 1462-0332 (Electronic)
IS  - 1462-0324 (Linking)
VI  - 52
IP  - 2
DP  - 2013 Feb
TI  - Contrast-enhanced MRI of normal temporomandibular joints in children--is there
      enhancement or not?
PG  - 363-7
LID - 10.1093/rheumatology/kes268 [doi]
AB  - OBJECTIVES: To determine the degree of contrast enhancement of normal TM joint
      (TMJ) in children and to provide reference data for patients with JIA. METHODS: A
      total of 100 dynamic contrast-enhanced MRI of 46 children from 1.6 to 18 years
      (median 9.1 years), who underwent the examinations for reasons other than TMJ
      disease, were retrospectively analysed in accordance with our local ethics
      committee. Time-intensity curves of the mandibular condyle and the soft tissue of
      the joint were assessed in relation to pre-contrast images and to muscle tissue. 
      RESULTS: After contrast injection the soft tissue of all joints showed a rapid
      initial increase of signal intensity (SI) followed by a slow increase, with the
      maximum after 6 min (end of the scan). Maximum SI in the joint tissue was on
      average 73% higher than pre-contrast, 53% higher than in the condyle and 20%
      higher than in an adjacent muscle. However, in 15% of measurements post-contrast 
      SI of the muscle was higher than that of the joint tissue. The enhancement curve 
      of the bone marrow in the condyle showed a peak by 2 min post-contrast.
      CONCLUSION: Contrast enhancement is a normal finding in the soft tissue and the
      condyle of the TMJ in children and adolescents. This should be taken into account
      when assessing the TMJ of children with JIA. As the relative enhancement of joint
      in comparison with muscle tissue proved to be variable, subtraction analysis of
      pre- and post-contrast T1 weighted images seems to provide a better basis for
      visual assessment.
FAU - von Kalle, Thekla
AU  - von Kalle T
AD  - Pediatric Radiology, Radiologisches Institut, Olgahospital Klinikum Stuttgart,
      Bismarckstr. 8, D-70176 Stuttgart, Germany. t.vonkalle@klinikum-stuttgart.de
FAU - Winkler, Peter
AU  - Winkler P
FAU - Stuber, Tina
AU  - Stuber T
LA  - eng
PT  - Journal Article
DEP - 20121011
PL  - England
TA  - Rheumatology (Oxford)
JT  - Rheumatology (Oxford, England)
JID - 100883501
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - *Contrast Media
MH  - Female
MH  - *Gadolinium DTPA
MH  - Humans
MH  - Image Enhancement/methods
MH  - Infant
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Mandibular Condyle/anatomy & histology
MH  - Observer Variation
MH  - Retrospective Studies
MH  - Temporomandibular Joint/*anatomy & histology
EDAT- 2012/10/16 06:00
MHDA- 2013/04/03 06:00
CRDT- 2012/10/16 06:00
PHST- 2012/10/16 06:00 [entrez]
PHST- 2012/10/16 06:00 [pubmed]
PHST- 2013/04/03 06:00 [medline]
AID - kes268 [pii]
AID - 10.1093/rheumatology/kes268 [doi]
PST - ppublish
SO  - Rheumatology (Oxford). 2013 Feb;52(2):363-7. doi: 10.1093/rheumatology/kes268.
      Epub 2012 Oct 11.


PMID- 23064523
OWN - NLM
STAT- MEDLINE
DCOM- 20130429
LR  - 20121105
IS  - 1661-4917 (Electronic)
IS  - 0004-069X (Linking)
VI  - 60
IP  - 6
DP  - 2012 Dec
TI  - New European rules regarding the approval of clinical trials, the role of ethics 
      committees and the protection of subjects.
PG  - 405-14
LID - 10.1007/s00005-012-0200-3 [doi]
FAU - Nys, Herman
AU  - Nys H
AD  - KU Leuven, Leuven, Belgium. Herman.Nys@med.kuleuven.be
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121013
PL  - Switzerland
TA  - Arch Immunol Ther Exp (Warsz)
JT  - Archivum immunologiae et therapiae experimentalis
JID - 0114365
SB  - IM
MH  - Clinical Trials as Topic/*ethics/legislation & jurisprudence
MH  - *Codes of Ethics/legislation & jurisprudence
MH  - Compensation and Redress
MH  - Emergencies
MH  - *Ethics Committees, Research/legislation & jurisprudence
MH  - Europe
MH  - Government Regulation
MH  - Health Policy/legislation & jurisprudence
MH  - Humans
MH  - Informed Consent
MH  - Liability, Legal
MH  - Practice Guidelines as Topic
MH  - *Research Subjects/legislation & jurisprudence
MH  - Therapeutic Human Experimentation/*ethics/legislation & jurisprudence
EDAT- 2012/10/16 06:00
MHDA- 2013/04/30 06:00
CRDT- 2012/10/16 06:00
PHST- 2012/09/15 00:00 [received]
PHST- 2012/09/24 00:00 [accepted]
PHST- 2012/10/16 06:00 [entrez]
PHST- 2012/10/16 06:00 [pubmed]
PHST- 2013/04/30 06:00 [medline]
AID - 10.1007/s00005-012-0200-3 [doi]
PST - ppublish
SO  - Arch Immunol Ther Exp (Warsz). 2012 Dec;60(6):405-14. doi:
      10.1007/s00005-012-0200-3. Epub 2012 Oct 13.


PMID- 23064488
OWN - NLM
STAT- MEDLINE
DCOM- 20130520
LR  - 20220330
IS  - 1432-1750 (Electronic)
IS  - 0341-2040 (Linking)
VI  - 190
IP  - 6
DP  - 2012 Dec
TI  - Early identification of small airways disease on lung cancer screening CT:
      comparison of current air trapping measures.
PG  - 629-33
LID - 10.1007/s00408-012-9422-8 [doi]
AB  - BACKGROUND: Lung cancer screening CT scans might provide valuable information
      about air trapping as an early indicator of smoking-related lung disease. We
      studied which of the currently suggested measures is most suitable for detecting 
      functionally relevant air trapping on low-dose computed tomography (CT) in a
      population of subjects with early-stage disease. METHODS: This study was
      ethically approved and informed consent was obtained. Three quantitative CT air
      trapping measures were compared against a functional reference standard in 427
      male lung cancer screening participants. This reference standard for air trapping
      was derived from the residual volume over total lung capacity ratio (RV/TLC)
      beyond the 95th percentile of predicted. The following CT air trapping measures
      were compared: expiratory to inspiratory relative volume change of voxels with
      attenuation values between -860 and -950 Hounsfield Units (RVC(-860 to -950)),
      expiratory to inspiratory ratio of mean lung density (E/I-ratio(MLD)) and
      percentage of voxels below -856 HU in expiration (EXP(-856)). Receiver operating 
      characteristic (ROC) analysis was performed and area under the ROC curve
      compared. RESULTS: Functionally relevant air trapping was present in 38 (8.9 %)
      participants. E/I-ratio(MLD) showed the largest area under the curve (0.85, 95 % 
      CI 0.813-0.883), which was significantly larger than RVC(-860 to -950) (0.703,
      0.657-0.746; p < 0.001) and EXP(-856) (0.798, 0.757-0.835; p = 0.002). At the
      optimum for sensitivity and specificity, E/I-ratio(MLD) yielded an accuracy of
      81.5 %. CONCLUSIONS: The expiratory to inspiratory ratio of mean lung density
      (E/I-ratio(MLD)) is most suitable for detecting air trapping on low-dose
      screening CT and performs significantly better than other suggested quantitative 
      measures.
FAU - Mets, Onno M
AU  - Mets OM
AD  - Department of Radiology, University Medical Centre Utrecht, Heidelberglaan 100,
      HP E01.132, Postbus 85500, 3508 GA, Utrecht, The Netherlands. metsonno@gmail.com
FAU - Zanen, Pieter
AU  - Zanen P
FAU - Lammers, Jan-Willem J
AU  - Lammers JW
FAU - Isgum, Ivana
AU  - Isgum I
FAU - Gietema, Hester A
AU  - Gietema HA
FAU - van Ginneken, Bram
AU  - van Ginneken B
FAU - Prokop, Mathias
AU  - Prokop M
FAU - de Jong, Pim A
AU  - de Jong PA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121012
PL  - United States
TA  - Lung
JT  - Lung
JID - 7701875
SB  - IM
MH  - Aged
MH  - *Early Detection of Cancer
MH  - Humans
MH  - Lung/*diagnostic imaging
MH  - Lung Neoplasms/*diagnosis
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Emphysema/diagnosis/diagnostic imaging/etiology
MH  - Respiratory Function Tests
MH  - Smoking/adverse effects
MH  - *Tomography, X-Ray Computed
EDAT- 2012/10/16 06:00
MHDA- 2013/05/22 06:00
CRDT- 2012/10/16 06:00
PHST- 2012/07/12 00:00 [received]
PHST- 2012/09/17 00:00 [accepted]
PHST- 2012/10/16 06:00 [entrez]
PHST- 2012/10/16 06:00 [pubmed]
PHST- 2013/05/22 06:00 [medline]
AID - 10.1007/s00408-012-9422-8 [doi]
PST - ppublish
SO  - Lung. 2012 Dec;190(6):629-33. doi: 10.1007/s00408-012-9422-8. Epub 2012 Oct 12.


PMID- 23063819
OWN - NLM
STAT- MEDLINE
DCOM- 20130521
LR  - 20121220
IS  - 1472-6491 (Electronic)
IS  - 1472-6483 (Linking)
VI  - 25
IP  - 7
DP  - 2012 Dec
TI  - The consequences of S.H. and Others v. Austria for legislation on gamete donation
      in Europe: an ethical analysis of the European Court of Human Rights judgments.
PG  - 665-9
LID - 10.1016/j.rbmo.2012.05.016 [doi]
LID - S1472-6483(12)00408-7 [pii]
AB  - There is a high degree of legal diversity within Europe concerning medically
      assisted reproduction. This is in direct opposition to the project of
      harmonization of the European institutions. This paper takes a closer look at the
      different national interpretations of the European Convention on Human Rights
      with regard to gamete donation. In the case of S.H. and Others v. Austria, the
      European Court of Human Rights originally condemned the prohibitions on egg
      donation and sperm donation for the purpose of IVF. The court judged the law to
      be incoherent and disproportionate. This decision was recently reversed on appeal
      based on the margin of appreciation doctrine. This paper critically reviews the
      judgments of the European Court of Human Rights and analyses what this case means
      for the future of legislation on medically assisted reproduction in Europe. It is
      concluded that legal diversity and cross-border reproductive care will persist
      and that the court failed to protect European patients from arbitrary
      interference with their right to procreation.
CI  - Copyright (c) 2012 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All
      rights reserved.
FAU - Van Hoof, Wannes
AU  - Van Hoof W
AD  - Bioethics Institute Ghent, Ghent University, Blandijnberg 2, B-9000 Ghent,
      Belgium. wannes.vanhoof@ugent.be
FAU - Pennings, Guido
AU  - Pennings G
LA  - eng
PT  - Journal Article
DEP - 20120704
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
SB  - IM
CIN - Reprod Biomed Online. 2012 Dec;25(7):660-2. PMID: 23063810
CIN - Reprod Biomed Online. 2012 Dec;25(7):663-4. PMID: 23063823
MH  - Austria
MH  - Directed Tissue Donation/*ethics/*legislation & jurisprudence
MH  - *Ethical Analysis
MH  - Europe
MH  - Human Rights/*legislation & jurisprudence
MH  - Humans
MH  - Judgment/*ethics
MH  - Reproductive Techniques, Assisted/ethics/legislation & jurisprudence
EDAT- 2012/10/16 06:00
MHDA- 2013/05/23 06:00
CRDT- 2012/10/16 06:00
PHST- 2012/02/13 00:00 [received]
PHST- 2012/05/29 00:00 [revised]
PHST- 2012/05/29 00:00 [accepted]
PHST- 2012/10/16 06:00 [entrez]
PHST- 2012/10/16 06:00 [pubmed]
PHST- 2013/05/23 06:00 [medline]
AID - S1472-6483(12)00408-7 [pii]
AID - 10.1016/j.rbmo.2012.05.016 [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2012 Dec;25(7):665-9. doi: 10.1016/j.rbmo.2012.05.016. Epub
      2012 Jul 4.


PMID- 23063216
OWN - NLM
STAT- MEDLINE
DCOM- 20140418
LR  - 20131216
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 98
DP  - 2013 Dec
TI  - Resisting the seduction of "ethics creep": using Foucault to surface complexity
      and contradiction in research ethics review.
PG  - 301-10
LID - 10.1016/j.socscimed.2012.09.019 [doi]
LID - S0277-9536(12)00682-X [pii]
AB  - In this paper we examine "ethics creep", a concept developed by Haggerty (2004)
      to account for the increasing bureaucratization of research ethics boards and
      institutional review boards (REB/IRBs) and the expanding reach of ethics review. 
      We start with an overview of the recent surge of academic interest in ethics
      creep and similar arguments about the prohibitive effect of ethics review. We
      then introduce elements of Michel Foucault's theoretical framework which are used
      to inform our analysis of empirical data drawn from a multi-phase study exploring
      the accessibility of community-engaged research within existing ethics review
      structures in Canada. First, we present how ethics creep emerged both explicitly 
      and implicitly in our data. We then present data that demonstrate how REB/IRBs
      are experiencing their own form of regulation. Finally, we present data that
      situate ethics review alongside other trends affecting the academy. Our results
      show that ethics review is growing in some ways while simultaneously being
      constrained in others. Drawing on Foucauldian theory we reframe ethics creep as a
      repressive hypothesis which belies the complexity of the phenomenon it purports
      to explain. Our discussion complicates ethics creep by proposing an understanding
      of REB/IRBs that locates them at the intersection of various neoliberal
      discourses about the role of science, ethics, and knowledge production.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Guta, Adrian
AU  - Guta A
AD  - Dalla Lana School of Public Health, University of Toronto, Canada; Joint Centre
      for Bioethics, University of Toronto, Canada. Electronic address:
      adrian.guta@mail.utoronto.ca.
FAU - Nixon, Stephanie A
AU  - Nixon SA
AD  - Dalla Lana School of Public Health, University of Toronto, Canada; Joint Centre
      for Bioethics, University of Toronto, Canada; Department of Physical Therapy,
      University of Toronto, Canada.
FAU - Wilson, Michael G
AU  - Wilson MG
AD  - McMaster Health Forum, Canada; Centre for Health Economics and Policy Analysis,
      McMaster University, Canada; Department of Clinical Epidemiology & Biostatistics,
      McMaster University, Canada; Ontario HIV Treatment Network, Canada.
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120925
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Canada
MH  - Community-Based Participatory Research/ethics
MH  - Empirical Research
MH  - Ethical Review/*standards
MH  - Ethics Committees, Research/*organization & administration
MH  - *Ethics, Research
MH  - Humans
MH  - Psychological Theory
OTO - NOTNLM
OT  - Canada
OT  - Discourse
OT  - Ethics creep
OT  - Ethics review
OT  - Foucault
OT  - Interviews
OT  - Neoliberalism
EDAT- 2012/10/16 06:00
MHDA- 2014/04/20 06:00
CRDT- 2012/10/16 06:00
PHST- 2011/12/20 00:00 [received]
PHST- 2012/09/10 00:00 [revised]
PHST- 2012/09/11 00:00 [accepted]
PHST- 2012/10/16 06:00 [entrez]
PHST- 2012/10/16 06:00 [pubmed]
PHST- 2014/04/20 06:00 [medline]
AID - S0277-9536(12)00682-X [pii]
AID - 10.1016/j.socscimed.2012.09.019 [doi]
PST - ppublish
SO  - Soc Sci Med. 2013 Dec;98:301-10. doi: 10.1016/j.socscimed.2012.09.019. Epub 2012 
      Sep 25.


PMID- 23063110
OWN - NLM
STAT- MEDLINE
DCOM- 20130524
LR  - 20121211
IS  - 1873-6386 (Electronic)
IS  - 0160-2527 (Linking)
VI  - 35
IP  - 5-6
DP  - 2012 Sep-Dec
TI  - Reflections on ethical issues in psychopharmacology: an American perspective.
PG  - 387-91
LID - 10.1016/j.ijlp.2012.09.007 [doi]
LID - S0160-2527(12)00070-2 [pii]
AB  - Psychopharmacology has revolutionized psychiatric practice but raises a number of
      ethical issues. This review from an American perspective first describes ethics
      analyses and attempts to portray the ethical practitioner. Pressures that
      interfere with appropriate prescribing come from outside the prescriber and from 
      within, including from insurers, other treatment staff and the prescriber's own
      will to act for the patient. Clinicians also face binds in which alternate
      choices seem to have merit and leave the prescriber feeling pulled in
      contradictory directions, frequently related to risk-benefit dilemmas. The ethics
      of psychopharmacology poses many questions that cannot yet be answered at the
      current state of the field. Pharmacology also seems to promote extremes of
      attitudes, such as "All such drugs are poisons" and the like. This review then
      provides some risk management principles, and concludes that such a review,
      though not comprehensive, may serve to open questions that are not always
      considered by clinicians.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Gutheil, Thomas G
AU  - Gutheil TG
AD  - Program in Psychiatry and the Law, Department of Psychiatry, Beth Israel
      Deaconess Medical Center, Harvard Medical School, United States. gutheiltg@cs.com
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121011
PL  - Netherlands
TA  - Int J Law Psychiatry
JT  - International journal of law and psychiatry
JID - 7806862
SB  - IM
MH  - Humans
MH  - Informed Consent
MH  - Psychiatry
MH  - Psychopharmacology/*ethics
MH  - Risk Management
MH  - United States
EDAT- 2012/10/16 06:00
MHDA- 2013/05/28 06:00
CRDT- 2012/10/16 06:00
PHST- 2012/10/16 06:00 [entrez]
PHST- 2012/10/16 06:00 [pubmed]
PHST- 2013/05/28 06:00 [medline]
AID - S0160-2527(12)00070-2 [pii]
AID - 10.1016/j.ijlp.2012.09.007 [doi]
PST - ppublish
SO  - Int J Law Psychiatry. 2012 Sep-Dec;35(5-6):387-91. doi:
      10.1016/j.ijlp.2012.09.007. Epub 2012 Oct 11.


PMID- 23062870
OWN - NLM
STAT- MEDLINE
DCOM- 20130812
LR  - 20140207
IS  - 1879-0046 (Electronic)
IS  - 0376-8716 (Linking)
VI  - 129
IP  - 1-2
DP  - 2013 Apr 1
TI  - DBS of nucleus accumbens on heroin seeking behaviors in self-administering rats.
PG  - 70-81
LID - 10.1016/j.drugalcdep.2012.09.012 [doi]
LID - S0376-8716(12)00376-6 [pii]
AB  - BACKGROUND: Surgical ablation of select brain areas has been frequently used to
      alleviate psychological dependence on opiate drugs in certain countries. However,
      ablative brain surgery was stopped in China in 2004 due to the related ethical
      controversy and possible side effects. Deep brain stimulation (DBS), a less
      invasive, reversible and adjustable process of neuromodulation, was adopted to
      attenuate relapses in studies of drug addiction. METHODS: Preclinical experiments
      were designed to assess the long-term effects of DBS of the nucleus accumbens
      (NAc) on cue- and heroin-induced reinstatement of drug seeking behaviors. After a
      rat self-administration model of heroin relapse was established, DBS was
      administered bilaterally or unilaterally to the NAc core through concentric
      bipolar electrodes. A 1-h long continuous stimulation (130 Hz, 100 mus, 0-150
      muA) was given daily for 7 days during the abstinence session. Drug seeking
      behaviors were elicited by conditioned cues or a small dose of heroin. RESULTS:
      75 muA and 150 muA bilateral NAc DBS attenuated cue- and heroin-induced
      reinstatement of drug seeking, and unilateral DBS of the right NAc achieved
      effects almost equivalent to bilateral DBS. Additional experiments showed that
      DBS had no long-term influence on locomotor activity and spatial learning and
      retention capabilities in Morris water maze tasks. Subsequent
      immunohistochemistry measurements revealed that the behavioral consequences were 
      associated with a significant increase in the expression of pCREB and a reduction
      in the expression of DeltaFosB in the NAc. CONCLUSIONS: These findings indicate
      that the NAc DBS could be an effective and safe therapeutic option for preventing
      relapse to heroin addiction.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Guo, Liemei
AU  - Guo L
AD  - Department of Neurosurgery, Renji Hospital, School of Medicine, Shanghai Jiaotong
      University, Shanghai 200127, China.
FAU - Zhou, Hongyu
AU  - Zhou H
FAU - Wang, Ran
AU  - Wang R
FAU - Xu, Jiwen
AU  - Xu J
FAU - Zhou, Wenhua
AU  - Zhou W
FAU - Zhang, Fuqiang
AU  - Zhang F
FAU - Tang, Shuaien
AU  - Tang S
FAU - Liu, Huifen
AU  - Liu H
FAU - Jiang, Jiyao
AU  - Jiang J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121011
PL  - Ireland
TA  - Drug Alcohol Depend
JT  - Drug and alcohol dependence
JID - 7513587
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Fosb protein, rat)
RN  - 0 (Narcotics)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 70D95007SX (Heroin)
SB  - IM
MH  - Animals
MH  - Catheterization
MH  - Conditioning, Operant
MH  - Cues
MH  - Cyclic AMP Response Element-Binding Protein/genetics/physiology
MH  - Deep Brain Stimulation/*methods
MH  - Drug-Seeking Behavior/*physiology
MH  - Electrodes, Implanted
MH  - Heroin/*pharmacology
MH  - Heroin Dependence/*psychology
MH  - Immunohistochemistry
MH  - Injections, Intraperitoneal
MH  - Male
MH  - Maze Learning/physiology
MH  - Motor Activity/physiology
MH  - Narcotics/*pharmacology
MH  - Nucleus Accumbens/*physiology
MH  - Phosphorylation
MH  - Proto-Oncogene Proteins c-fos/genetics/physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Self Administration
EDAT- 2012/10/16 06:00
MHDA- 2013/08/13 06:00
CRDT- 2012/10/16 06:00
PHST- 2012/04/02 00:00 [received]
PHST- 2012/08/09 00:00 [revised]
PHST- 2012/09/16 00:00 [accepted]
PHST- 2012/10/16 06:00 [entrez]
PHST- 2012/10/16 06:00 [pubmed]
PHST- 2013/08/13 06:00 [medline]
AID - S0376-8716(12)00376-6 [pii]
AID - 10.1016/j.drugalcdep.2012.09.012 [doi]
PST - ppublish
SO  - Drug Alcohol Depend. 2013 Apr 1;129(1-2):70-81. doi:
      10.1016/j.drugalcdep.2012.09.012. Epub 2012 Oct 11.


PMID- 23062625
OWN - NLM
STAT- MEDLINE
DCOM- 20130705
LR  - 20121119
IS  - 1618-1301 (Electronic)
IS  - 0018-442X (Linking)
VI  - 63
IP  - 6
DP  - 2012 Dec
TI  - Chacarita Project: conformation and analysis of a modern and documented human
      osteological collection from Buenos Aires City--theoretical, methodological and
      ethical aspects.
PG  - 481-92
LID - 10.1016/j.jchb.2012.06.003 [doi]
LID - S0018-442X(12)00094-7 [pii]
AB  - Osteological reference collections play a key role in bioanthropological
      research; they allow the development and testing of methods for sexing and ageing
      individuals using various bone and dental attributes. This paper presents the
      first stage results of the ongoing Chacarita Research Project, which aims to
      generate and study a reference collection of adult skeletons representative of
      the contemporary population of Buenos Aires city. The Chacarita Collection
      consists of unclaimed human remains of individuals of known nationality, sex,
      age, cause and date of death from the Chacarita Public Cemetery. Unlike other
      similar endeavours, this sample has been completely exhumed using archaeological 
      techniques. So far, a total of 146 adult skeletons have been recovered (60
      females - 41.1% and 86 males - 58.90%), the majority of which have ages-at-death 
      in the range of 71-90 years. They were born primarily in Argentina (n=133;
      91.1%), although other nationalities are also represented. Dates of death range
      between 1987 and 2000. In the short term, the osteological study of this
      collection will allow assessment of the performance of classical methods of sex
      determination and age-at-death estimation in a local setting. A special priority 
      will be given to the study of osteological changes in individuals over 50 years. 
      As the sample is being retrieved by exhumation, the impact of taphonomic agents
      on the most diagnostic bone structures is also being assessed. In the long term, 
      this osteological collection will be available to generate new
      population-specific techniques and to develop comparative biological studies.
CI  - Copyright (c) 2012 Elsevier GmbH. All rights reserved.
FAU - Bosio, L A
AU  - Bosio LA
AD  - Servicio de Antropologia Forense, Catedra de Medicina Legal, Facultad de
      Medicina, Universidad de Buenos Aires, Ciudad Autonoma de Buenos Aires, C1121ABG,
      Argentina.
FAU - Garcia Guraieb, S
AU  - Garcia Guraieb S
FAU - Luna, L H
AU  - Luna LH
FAU - Aranda, C
AU  - Aranda C
LA  - eng
PT  - Journal Article
DEP - 20121009
PL  - Germany
TA  - Homo
JT  - Homo : internationale Zeitschrift fur die vergleichende Forschung am Menschen
JID - 0374655
SB  - IM
MH  - Adult
MH  - Age Determination by Skeleton/*ethics/*methods
MH  - Aged
MH  - Aged, 80 and over
MH  - Argentina
MH  - Bone and Bones/anatomy & histology
MH  - Female
MH  - Forensic Anthropology/ethics/methods
MH  - Humans
MH  - *Library Collection Development
MH  - Male
MH  - Middle Aged
MH  - Osteology/ethics/methods
MH  - Reference Standards
MH  - Sex Determination by Skeleton/*ethics/*methods
EDAT- 2012/10/16 06:00
MHDA- 2013/07/06 06:00
CRDT- 2012/10/16 06:00
PHST- 2011/11/10 00:00 [received]
PHST- 2012/06/21 00:00 [accepted]
PHST- 2012/10/16 06:00 [entrez]
PHST- 2012/10/16 06:00 [pubmed]
PHST- 2013/07/06 06:00 [medline]
AID - S0018-442X(12)00094-7 [pii]
AID - 10.1016/j.jchb.2012.06.003 [doi]
PST - ppublish
SO  - Homo. 2012 Dec;63(6):481-92. doi: 10.1016/j.jchb.2012.06.003. Epub 2012 Oct 9.


PMID- 23062515
OWN - NLM
STAT- MEDLINE
DCOM- 20130410
LR  - 20121015
IS  - 1471-6348 (Electronic)
IS  - 0266-4623 (Linking)
VI  - 28
IP  - 4
DP  - 2012 Oct
TI  - Key informants' perceptions of how pharmac operates in New Zealand.
PG  - 367-73
LID - 10.1017/S0266462312000566 [doi]
AB  - OBJECTIVES: The aim of this study is to examine key informants' perceptions of
      how the New Zealand Pharmaceutical Management Agency (PHARMAC) operates in New
      Zealand. METHODS: We carried out qualitative analysis of semi-structured
      interviews with key informants. We obtained ethics approval from the University
      of Otago School of Pharmacy, and all participants gave informed consent. We
      digitally recorded the interviews, which were then transcribed, and coded in
      NVivo. The data were analyzed by theme using constant comparison methods. Twenty 
      informants who had previously published research or commentary on New Zealand's
      access to medicines, acted as spokespersons for interest groups, or held
      positions that gave them key insights into New Zealand's medicines system agreed 
      to participate. Informants were purposefully selected to ensure a wide range of
      views, including five people working in medicine, four in pharmacy, three Members
      of Parliament from different parties, and two each from PHARMAC and the
      pharmaceutical industry. RESULTS: Respondents saw PHARMAC as an organization that
      contained medicine costs effectively, was politically neutral, and resistant to
      lobbying. It enjoyed broad political support and, with extremely rare exceptions,
      had been allowed to carry out its functions independently regardless of who was
      in government. As a result of this political stability, the relationship between 
      PHARMAC and the pharmaceutical industry has been improving. CONCLUSION: PHARMAC's
      longevity and increasing influence are largely due to political choices made to
      prioritize containing pharmaceutical expenditure and to respecting PHARMAC's
      independence. This may be difficult to replicate in other countries.
FAU - Ragupathy, Rajan
AU  - Ragupathy R
AD  - School of Pharmacy, University of Otago, Dunedin New Zealand.
      rajan.ragupathy@gmail.com
FAU - Tordoff, June
AU  - Tordoff J
FAU - Norris, Pauline
AU  - Norris P
FAU - Reith, David
AU  - Reith D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Technol Assess Health Care
JT  - International journal of technology assessment in health care
JID - 8508113
SB  - IM
MH  - Attitude of Health Personnel
MH  - Drug Industry/economics/*statistics & numerical data
MH  - *Health Care Reform
MH  - *Health Policy
MH  - Humans
MH  - New Zealand
MH  - *Perception
MH  - Politics
EDAT- 2012/10/16 06:00
MHDA- 2013/04/11 06:00
CRDT- 2012/10/16 06:00
PHST- 2012/10/16 06:00 [entrez]
PHST- 2012/10/16 06:00 [pubmed]
PHST- 2013/04/11 06:00 [medline]
AID - S0266462312000566 [pii]
AID - 10.1017/S0266462312000566 [doi]
PST - ppublish
SO  - Int J Technol Assess Health Care. 2012 Oct;28(4):367-73. doi:
      10.1017/S0266462312000566.


PMID- 23062459
OWN - NLM
STAT- MEDLINE
DCOM- 20130405
LR  - 20131121
IS  - 0013-7006 (Print)
IS  - 0013-7006 (Linking)
VI  - 38
IP  - 5
DP  - 2012 Oct
TI  - [Homicide and acute cortico-induced psychosis: A case report].
PG  - 440-4
LID - 10.1016/j.encep.2011.11.007 [doi]
LID - S0013-7006(11)00222-3 [pii]
AB  - BACKGROUND: Since their commercialization in 1950, the first psychiatric side
      effects of steroids have been reported. Today, steroids have become an important 
      therapeutic tool in many diseases, but pharmacological mechanisms responsible for
      their side effects are still little known. The neuropsychiatric side effects
      concern 15% of patients while severe reactions occur in 5% of cases, mostly as
      acute psychotic episodes such as delusion. Serious forensic risks in this context
      are poorly documented and underestimated. CASE REPORT: We report the case of a 77
      year-old man, treated by methylprednisolone for chronic lymphoid leukemia. After 
      two months of treatment, although stabilized for the neoplastic disease, he
      stabbed his wife to death with a knife. In the emergency unit, an acute delirious
      state, a disorganization syndrome, and confusion items such as amnesia,
      disorientation and symptomatology fluctuation were observed. Mr. M also presented
      with hyponatremia and infectious pneumonia. Steroids were stopped and his
      condition rapidly declined, he died one month later during the hospitalization.
      DISCUSSION: This clinical case underlines the importance of the early detection
      of steroid psychosis and its management. Treatment should not be stopped brutally
      and a dose reducing strategy should be applied in combination with a mood
      stabilizer or antipsychotic treatment. Disease management strategies are
      insufficiently documented to be recommended. The extremely acute onset of the
      symptoms, a partial insight into delusions, a history of iatrogenic
      neuropsychiatry, the existence of somatic precipitating disorders and confusion
      factors should always alert the practitioner. The patient, and eventually his
      family circle, must be aware of the risks of adverse psychiatric effects of
      steroids for both ethical and forensic reasons, and must report them as early as 
      possible to the clinician if they occur.
CI  - Copyright (c) 2011 L'Encephale, Paris. Published by Elsevier Masson SAS. All
      rights reserved.
FAU - Airagnes, G
AU  - Airagnes G
AD  - Departement de psychiatrie et de psychologie medicale, CHU d'Angers, 49933 Angers
      cedex 09, France. guillaumeairagnes@yahoo.fr
FAU - Rouge-Maillart, C
AU  - Rouge-Maillart C
FAU - Garre, J-B
AU  - Garre JB
FAU - Gohier, B
AU  - Gohier B
LA  - fre
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - Homicide et episode psychotique aigu cortico-induit : a propos d'un cas.
DEP - 20120104
PL  - France
TA  - Encephale
JT  - L'Encephale
JID - 7505643
RN  - 0 (Anti-Inflammatory Agents)
RN  - X4W7ZR7023 (Methylprednisolone)
SB  - IM
MH  - Aged
MH  - Anti-Inflammatory Agents/*adverse effects/therapeutic use
MH  - Diagnosis, Differential
MH  - Early Diagnosis
MH  - Fatal Outcome
MH  - Homicide/*psychology
MH  - Humans
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/*diagnosis/psychology
MH  - Male
MH  - Methylprednisolone/*adverse effects/therapeutic use
MH  - Psychoses, Substance-Induced/*diagnosis/*psychology
MH  - Substance Withdrawal Syndrome/diagnosis/mortality
EDAT- 2012/10/16 06:00
MHDA- 2013/04/06 06:00
CRDT- 2012/10/16 06:00
PHST- 2011/02/28 00:00 [received]
PHST- 2011/08/29 00:00 [accepted]
PHST- 2012/10/16 06:00 [entrez]
PHST- 2012/10/16 06:00 [pubmed]
PHST- 2013/04/06 06:00 [medline]
AID - S0013-7006(11)00222-3 [pii]
AID - 10.1016/j.encep.2011.11.007 [doi]
PST - ppublish
SO  - Encephale. 2012 Oct;38(5):440-4. doi: 10.1016/j.encep.2011.11.007. Epub 2012 Jan 
      4.


PMID- 23062455
OWN - NLM
STAT- MEDLINE
DCOM- 20130405
LR  - 20121015
IS  - 0013-7006 (Print)
IS  - 0013-7006 (Linking)
VI  - 38
IP  - 5
DP  - 2012 Oct
TI  - [The legal limits and ambiguities of the role of the family caregivers].
PG  - 411-7
LID - 10.1016/j.encep.2011.12.004 [doi]
LID - S0013-7006(11)00229-6 [pii]
AB  - INTRODUCTION: While living in a period easily characterized by the
      self-actualization of the patient as the support of a non-professional valuation,
      it seems useful to evaluate the situation concerning the limits of the
      involvement of the non-professional caregivers who take care of dependent or
      disabled persons. They become involved in the course of care in order to protect 
      their relative the best way they can. This involvement has an influence on the
      evolution of the care, particularly from a psychic point of view, as well as in
      the way any medical act will be conducted. OBJECTIVES: This work analyses the
      French legal context, reflecting the practical experience of the
      gerontopsychiatric teams. A legal point is established on the outlines of the
      voluntary help provided by the relatives and/or close friends. The approach,
      aiming at recognizing the family caregivers as such and bearing in mind that they
      can almost become the persons' guardians if need be, cannot but provoke several
      ethical issues as well as difficulties concerning the way of taking care of the
      patient. The difficulties the caregivers may have are in a way related to the
      lack of clear legal definitions of the medical act, as well as to the lack of
      definitions of the tasks one may expect from the family caregiver. CONCLUSIONS:
      This lack also shows the difficulties the law-maker is confronted with when
      defining what concerns the natural family care and what concerns the collective
      solidarity. The evolution of the role of caregivers in our society, which must
      face the pandemic of chronic diseases, thus means an evolution in the substantive
      law in the field of family care.
CI  - Copyright (c) 2012 L'Encephale, Paris. Published by Elsevier Masson SAS. All
      rights reserved.
FAU - Hazif-Thomas, C
AU  - Hazif-Thomas C
AD  - JE 2535, UBO Brest, intersecteur de psychiatrie du sujet age, centre hospitalier 
      de Bohars, CHU de Brest, 29200 Brest, France. c.hazif-thomas@ch.quimperle.fr
FAU - Thomas, P
AU  - Thomas P
FAU - Tritschler-LeMaitre, M-H
AU  - Tritschler-LeMaitre MH
FAU - Walter, M
AU  - Walter M
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Limites et ambiguites juridiques du role des aidants familiaux.
DEP - 20120124
PL  - France
TA  - Encephale
JT  - L'Encephale
JID - 7505643
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alzheimer Disease/nursing/psychology
MH  - Caregivers/ethics/*legislation & jurisprudence/*psychology
MH  - Chronic Disease/*nursing/*psychology
MH  - Communication
MH  - Confidentiality/legislation & jurisprudence
MH  - Cooperative Behavior
MH  - *Cost of Illness
MH  - Disabled Persons/*psychology
MH  - Ethics, Medical
MH  - Family Relations
MH  - Female
MH  - France
MH  - Geriatric Psychiatry/legislation & jurisprudence
MH  - Home Nursing/*legislation & jurisprudence/*psychology
MH  - Humans
MH  - Interdisciplinary Communication
MH  - Legal Guardians/legislation & jurisprudence
MH  - Male
MH  - Middle Aged
MH  - Motivation
MH  - Quality of Life/legislation & jurisprudence/psychology
EDAT- 2012/10/16 06:00
MHDA- 2013/04/06 06:00
CRDT- 2012/10/16 06:00
PHST- 2011/02/02 00:00 [received]
PHST- 2011/09/29 00:00 [accepted]
PHST- 2012/10/16 06:00 [entrez]
PHST- 2012/10/16 06:00 [pubmed]
PHST- 2013/04/06 06:00 [medline]
AID - S0013-7006(11)00229-6 [pii]
AID - 10.1016/j.encep.2011.12.004 [doi]
PST - ppublish
SO  - Encephale. 2012 Oct;38(5):411-7. doi: 10.1016/j.encep.2011.12.004. Epub 2012 Jan 
      24.


PMID- 23061929
OWN - NLM
STAT- MEDLINE
DCOM- 20130205
LR  - 20181202
IS  - 1365-2044 (Electronic)
IS  - 0003-2409 (Linking)
VI  - 68
IP  - 1
DP  - 2013 Jan
TI  - Research in children and ethical limits: the water laryngospasm challenge.
PG  - 1-3
LID - 10.1111/anae.12005 [doi]
FAU - Durward, A
AU  - Durward A
LA  - eng
PT  - Editorial
PT  - Comment
DEP - 20121012
PL  - England
TA  - Anaesthesia
JT  - Anaesthesia
JID - 0370524
RN  - 0 (Anesthetics, Local)
RN  - 98PI200987 (Lidocaine)
SB  - IM
CON - Anaesthesia. 2013 Jan;68(1):13-20. PMID: 23061716
CIN - Anaesthesia. 2013 May;68(5):532. PMID: 23573848
CIN - Anaesthesia. 2013 May;68(5):532-3. PMID: 23573849
CIN - Anaesthesia. 2013 May;68(5):533-4. PMID: 23573850
CIN - Anaesthesia. 2013 May;68(5):534-5. PMID: 23573851
CIN - Anaesthesia. 2013 May;68(5):535-6. PMID: 23573852
MH  - *Anesthesia, General
MH  - Anesthetics, Local/*therapeutic use
MH  - Female
MH  - Humans
MH  - Larynx/*drug effects
MH  - Lidocaine/*therapeutic use
MH  - Male
MH  - Reflex/*drug effects
MH  - Respiratory Mechanics/*drug effects
EDAT- 2012/10/16 06:00
MHDA- 2013/02/06 06:00
CRDT- 2012/10/16 06:00
PHST- 2012/10/16 06:00 [entrez]
PHST- 2012/10/16 06:00 [pubmed]
PHST- 2013/02/06 06:00 [medline]
AID - 10.1111/anae.12005 [doi]
PST - ppublish
SO  - Anaesthesia. 2013 Jan;68(1):1-3. doi: 10.1111/anae.12005. Epub 2012 Oct 12.


PMID- 23061799
OWN - NLM
STAT- MEDLINE
DCOM- 20140307
LR  - 20151119
IS  - 1473-0782 (Electronic)
IS  - 1362-5187 (Linking)
VI  - 17
IP  - 6
DP  - 2012 Dec
TI  - Knowledge and attitudes of Swedish politicians concerning induced abortion.
PG  - 438-50
LID - 10.3109/13625187.2012.719656 [doi]
AB  - OBJECTIVE: Induced abortion is more frequent in Sweden than in many other Western
      countries. We wanted to investigate attitudes and knowledge about induced
      abortion among politicians responsible for healthcare in three Swedish counties. 
      METHOD: A study-specific questionnaire was sent to all 375 elected politicians in
      three counties; 192 (51%) responded. RESULTS: The politicians stated that they
      were knowledgeable about the Swedish abortion law. More than half did not
      consider themselves, in their capacity as politicians, sufficiently informed
      about abortion-related matters. Most politicians (72%) considered induced
      abortion to be primarily a 'women's rights issue' rather than an ethical one, and
      54% considered 12 weeks' gestational age an adequate upper limit for induced
      abortion. Only about a third of the respondents were correctly informed about the
      number of induced abortions annually carried out in Sweden. CONCLUSION:
      Information and knowledge on induced abortion among Swedish county politicians
      seem not to be optimal. Changes aimed at reducing the current high abortion rates
      will probably not be easy to achieve as politicians seem to be reluctant to
      commit themselves on ethical issues and consider induced abortion mainly a
      women's rights issue.
FAU - Sydsjo, Adam
AU  - Sydsjo A
AD  - Division of Obstetrics and Gynaecology, Department of Clinical and Experimental
      Medicine, Faculty of Health Sciences, Linkoping University, and Department of
      Obstetrics and Gynaecology in Linkoping, County Council of Ostergotland ,
      Linkoping , Sweden.
FAU - Josefsson, Ann
AU  - Josefsson A
FAU - Bladh, Marie
AU  - Bladh M
FAU - Muhrbeck, Mans
AU  - Muhrbeck M
FAU - Sydsjo, Gunilla
AU  - Sydsjo G
LA  - eng
PT  - Journal Article
DEP - 20121014
PL  - England
TA  - Eur J Contracept Reprod Health Care
JT  - The European journal of contraception & reproductive health care : the official
      journal of the European Society of Contraception
JID - 9712127
SB  - IM
MH  - Abortion, Induced/education/*psychology
MH  - Abortion, Legal/education/ethics/*legislation & jurisprudence
MH  - Female
MH  - Gestational Age
MH  - *Health Knowledge, Attitudes, Practice
MH  - Health Literacy/statistics & numerical data
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Politics
MH  - Pregnancy
MH  - Religion and Psychology
MH  - *Reproductive Health
MH  - Surveys and Questionnaires
MH  - Sweden
MH  - Women's Health Services/standards
MH  - Women's Rights
EDAT- 2012/10/16 06:00
MHDA- 2014/03/08 06:00
CRDT- 2012/10/16 06:00
PHST- 2012/10/16 06:00 [entrez]
PHST- 2012/10/16 06:00 [pubmed]
PHST- 2014/03/08 06:00 [medline]
AID - 10.3109/13625187.2012.719656 [doi]
PST - ppublish
SO  - Eur J Contracept Reprod Health Care. 2012 Dec;17(6):438-50. doi:
      10.3109/13625187.2012.719656. Epub 2012 Oct 14.


PMID- 23061742
OWN - NLM
STAT- MEDLINE
DCOM- 20130617
LR  - 20130107
IS  - 1460-9592 (Electronic)
IS  - 1155-5645 (Linking)
VI  - 23
IP  - 2
DP  - 2013 Feb
TI  - A comparison of three methods that assess tracheal tube leakage: leak
      conductance, fractional volume loss, and audible assessment.
PG  - 111-6
LID - 10.1111/pan.12043 [doi]
AB  - BACKGROUND: When intubating a child's trachea with an uncuffed tracheal tube
      (TT), it is current practice in anesthesia and intensive care to use the leak
      test to assess TT fit. The aim of this study is to compare three measures of
      assessing leak around uncuffed tracheal tubes in the PICU. METHODS: We obtained
      institutional ethical permission and written informed consent, prior to any
      clinical investigation, from the parents of 135 children who had surgery for
      cardiac defects. On admission to the PICU, we measured leak by audible
      assessment, fractional volume loss, and leak conductance for each patient.
      Measurements of fractional volume loss and leak conductance were repeated every 4
      h thereafter until extubation. RESULTS: On admission to the PICU, calculated
      values of leak conductance were significantly different between each grade of
      audible leak (P < 0.001). Values of fractional volume loss were not significantly
      different between 'no leak' and 'small leak' grades of leak. Throughout the PICU 
      stay, a significant correlation between mean leak conductance and mean fractional
      volume loss was found (0.86, 95% CI, 0.81-0.90). Significant agreement within
      time series of leak conductance and fractional volume recorded for each patient
      occurred in 47/128 cases (37%). CONCLUSIONS: On admission to the PICU, values of 
      leak conductance are more strongly associated with audible assessment than with
      fractional volume loss. Throughout PICU stay, leak conductance is associated with
      fractional volume loss. This study demonstrates that leak conductance, calculated
      from routinely available pressure and flow signals, has the potential to
      represent the characteristics of the leak interface between a TT and the trachea.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Smith, Jon H
AU  - Smith JH
AD  - Freeman Hospital, Newcastle Upon Tyne, UK. jon.smith@nuth.nhs.uk
FAU - Keltie, Kim
AU  - Keltie K
FAU - Murphy, Tim
AU  - Murphy T
FAU - Raj, Naveen
AU  - Raj N
FAU - Lane, Mary
AU  - Lane M
FAU - Ranger, Michael
AU  - Ranger M
FAU - Sims, Andrew J
AU  - Sims AJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121013
PL  - France
TA  - Paediatr Anaesth
JT  - Paediatric anaesthesia
JID - 9206575
SB  - IM
MH  - Airway Management/*methods
MH  - Cardiac Surgical Procedures
MH  - Child, Preschool
MH  - Equipment Failure
MH  - *Equipment Failure Analysis
MH  - Female
MH  - Heart Defects, Congenital/surgery
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Intubation, Intratracheal/*methods
MH  - Male
MH  - Prospective Studies
EDAT- 2012/10/16 06:00
MHDA- 2013/06/19 06:00
CRDT- 2012/10/16 06:00
PHST- 2012/08/16 00:00 [accepted]
PHST- 2012/10/16 06:00 [entrez]
PHST- 2012/10/16 06:00 [pubmed]
PHST- 2013/06/19 06:00 [medline]
AID - 10.1111/pan.12043 [doi]
PST - ppublish
SO  - Paediatr Anaesth. 2013 Feb;23(2):111-6. doi: 10.1111/pan.12043. Epub 2012 Oct 13.


PMID- 23061659
OWN - NLM
STAT- MEDLINE
DCOM- 20130205
LR  - 20181202
IS  - 1365-2044 (Electronic)
IS  - 0003-2409 (Linking)
VI  - 68
IP  - 1
DP  - 2013 Jan
TI  - Small patients, big ethics.
PG  - 6-8
LID - 10.1111/anae.12061 [doi]
FAU - Bailey, C R
AU  - Bailey CR
FAU - Yentis, S M
AU  - Yentis SM
LA  - eng
PT  - Editorial
PT  - Comment
DEP - 20121012
PL  - England
TA  - Anaesthesia
JT  - Anaesthesia
JID - 0370524
RN  - 0 (Anesthetics, Local)
RN  - 98PI200987 (Lidocaine)
SB  - IM
CON - Anaesthesia. 2013 Jan;68(1):13-20. PMID: 23061716
CIN - Anaesthesia. 2013 May;68(5):532. PMID: 23573848
CIN - Anaesthesia. 2013 May;68(5):532-3. PMID: 23573849
CIN - Anaesthesia. 2013 May;68(5):533-4. PMID: 23573850
CIN - Anaesthesia. 2013 May;68(5):534-5. PMID: 23573851
CIN - Anaesthesia. 2013 May;68(5):535-6. PMID: 23573852
CIN - Anaesthesia. 2013 Sep;68(9):979-80. PMID: 24047362
CIN - Anaesthesia. 2013 Sep;68(9):980. PMID: 24047364
MH  - *Anesthesia, General
MH  - Anesthetics, Local/*therapeutic use
MH  - Female
MH  - Humans
MH  - Larynx/*drug effects
MH  - Lidocaine/*therapeutic use
MH  - Male
MH  - Reflex/*drug effects
MH  - Respiratory Mechanics/*drug effects
EDAT- 2012/10/16 06:00
MHDA- 2013/02/06 06:00
CRDT- 2012/10/16 06:00
PHST- 2012/10/16 06:00 [entrez]
PHST- 2012/10/16 06:00 [pubmed]
PHST- 2013/02/06 06:00 [medline]
AID - 10.1111/anae.12061 [doi]
PST - ppublish
SO  - Anaesthesia. 2013 Jan;68(1):6-8. doi: 10.1111/anae.12061. Epub 2012 Oct 12.


PMID- 23061616
OWN - NLM
STAT- MEDLINE
DCOM- 20131112
LR  - 20121015
IS  - 1478-5153 (Electronic)
IS  - 1362-1017 (Linking)
VI  - 17
IP  - 6
DP  - 2012 Nov-Dec
TI  - Critical care in the era of global economic crisis: a nursing ethics perspective.
PG  - 275-8
LID - 10.1111/j.1478-5153.2012.00536.x [doi]
FAU - Papathanassoglou, Elizabeth D E
AU  - Papathanassoglou ED
FAU - Mpouzika, Meropi D A
AU  - Mpouzika MD
LA  - eng
PT  - Editorial
PL  - England
TA  - Nurs Crit Care
JT  - Nursing in critical care
JID - 9808649
MH  - Critical Care/*economics/*ethics
MH  - *Ethics, Nursing
MH  - Health Services Accessibility/*economics/*ethics
MH  - Humans
EDAT- 2012/10/16 06:00
MHDA- 2013/11/13 06:00
CRDT- 2012/10/16 06:00
PHST- 2012/10/16 06:00 [entrez]
PHST- 2012/10/16 06:00 [pubmed]
PHST- 2013/11/13 06:00 [medline]
AID - 10.1111/j.1478-5153.2012.00536.x [doi]
PST - ppublish
SO  - Nurs Crit Care. 2012 Nov-Dec;17(6):275-8. doi: 10.1111/j.1478-5153.2012.00536.x.


PMID- 23061592
OWN - NLM
STAT- MEDLINE
DCOM- 20131119
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 40
IP  - 3
DP  - 2012 Fall
TI  - Pediatric participation in non-therapeutic research.
PG  - 665-72
LID - 10.1111/j.1748-720X.2012.00697.x [doi]
AB  - United Stated federal regulations allow participation of children in greater than
      minimal risk research with no potential for direct benefit under narrowly defined
      circumstances. This type of research is controversial, as it runs contrary to the
      best interest standard, on which we base most decisions made on behalf of
      children. I argue that such research is ethically defensible if a fully informed,
      scrupulous, and virtuous parent would choose to enroll his or her child in the
      study. Further, I defend the current regulations, which allow local Institutional
      Review Boards to approve more than minimal risk, nontherapeutic research when the
      research involves children with the medical condition being studied, but requires
      federal review for similarly risky studies that involve healthy children. Because
      families of children with medical diseases tend to be more familiar with the
      health care system and with medical procedures, they are more able to make
      informed decisions about the burdens of research participation. Further, parents 
      of children with medical conditions have a morally significant interest in
      advancing medical knowledge about their child's condition. It is appropriate to
      take this interest into account when evaluating the ethical status of a research 
      study.
CI  - (c) 2012 American Society of Law, Medicine & Ethics, Inc.
FAU - Morris, Marilyn C
AU  - Morris MC
AD  - Columbia University.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Child
MH  - Child Welfare/*ethics/legislation & jurisprudence
MH  - Humans
MH  - Informed Consent/ethics
MH  - Nontherapeutic Human Experimentation/*ethics/legislation & jurisprudence
MH  - *Public Policy
MH  - Research Support as Topic/standards
MH  - Risk Assessment
MH  - United States
EDAT- 2012/10/16 06:00
MHDA- 2013/11/20 06:00
CRDT- 2012/10/16 06:00
PHST- 2012/10/16 06:00 [entrez]
PHST- 2012/10/16 06:00 [pubmed]
PHST- 2013/11/20 06:00 [medline]
AID - 10.1111/j.1748-720X.2012.00697.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2012 Fall;40(3):665-72. doi: 10.1111/j.1748-720X.2012.00697.x.


PMID- 23061589
OWN - NLM
STAT- MEDLINE
DCOM- 20131119
LR  - 20211021
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 40
IP  - 3
DP  - 2012 Fall
TI  - A trade secret model for genomic biobanking.
PG  - 612-29
LID - 10.1111/j.1748-720X.2012.00694.x [doi]
AB  - Genomic biobanks present ethical challenges that are qualitatively unique and
      quantitatively unprecedented. Many critics have questioned whether the current
      system of informed consent can be meaningfully applied to genomic biobanking.
      Proposals for reform have come from many directions, but have tended to involve
      incremental change in current informed consent practice. This paper reports on
      our efforts to seek new ideas and approaches from those whom informed consent is 
      designed to protect: research subjects. Our model emerged from semi-structured
      interviews with healthy volunteers who had been recruited to join either of two
      biobanks (some joined, some did not), and whom we encouraged to explain their
      concerns and how they understood the relationship between specimen contributors
      and biobanks. These subjects spoke about their DNA and the information it
      contains in ways that were strikingly evocative of the legal concept of the trade
      secret. They then described the terms and conditions under which they might let
      others study their DNA, and there was a compelling analogy to the commonplace
      practice of trade secret licensing. We propose a novel biobanking model based on 
      this trade secret concept, and argue that it would be a practical, legal, and
      ethical improvement on the status quo.
CI  - (c) 2012 American Society of Law, Medicine & Ethics, Inc.
FAU - Conley, John M
AU  - Conley JM
AD  - University of North Carolina at Chapel Hill.
FAU - Mitchell, Robert
AU  - Mitchell R
FAU - Cadigan, R Jean
AU  - Cadigan RJ
FAU - Davis, Arlene M
AU  - Davis AM
FAU - Dobson, Allison W
AU  - Dobson AW
FAU - Gladden, Ryan Q
AU  - Gladden RQ
LA  - eng
GR  - P50 HG004488/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Attitude to Health
MH  - Biological Specimen Banks/*ethics/*legislation & jurisprudence
MH  - *Confidentiality/ethics/legislation & jurisprudence
MH  - *Genome, Human
MH  - Gift Giving
MH  - *Government Regulation
MH  - Humans
MH  - *Informed Consent/ethics/legislation & jurisprudence
MH  - Licensure/legislation & jurisprudence
MH  - Models, Theoretical
MH  - Ownership/legislation & jurisprudence
MH  - Tissue Donors
MH  - United States
PMC - PMC3476050
MID - NIHMS384476
EDAT- 2012/10/16 06:00
MHDA- 2013/11/20 06:00
CRDT- 2012/10/16 06:00
PHST- 2012/10/16 06:00 [entrez]
PHST- 2012/10/16 06:00 [pubmed]
PHST- 2013/11/20 06:00 [medline]
AID - 10.1111/j.1748-720X.2012.00694.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2012 Fall;40(3):612-29. doi: 10.1111/j.1748-720X.2012.00694.x.


PMID- 23061579
OWN - NLM
STAT- MEDLINE
DCOM- 20131119
LR  - 20211021
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 40
IP  - 3
DP  - 2012 Fall
TI  - Introduction: The Health Care Reform Law (PPACA): controversies in ethics and
      policy.
PG  - 523-5
LID - 10.1111/j.1748-720X.2012.00684.x [doi]
FAU - Sade, Robert M
AU  - Sade RM
AD  - Medical University of South Carolina.
LA  - eng
GR  - UL1 RR029882/RR/NCRR NIH HHS/United States
GR  - UL1RR029882/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Health Care Reform/*ethics/*legislation & jurisprudence
MH  - Humans
MH  - Patient Protection and Affordable Care Act/*ethics/*legislation & jurisprudence
MH  - Politics
MH  - *Supreme Court Decisions
MH  - United States
PMC - PMC4489407
MID - NIHMS702756
EDAT- 2012/10/16 06:00
MHDA- 2013/11/20 06:00
CRDT- 2012/10/16 06:00
PHST- 2012/10/16 06:00 [entrez]
PHST- 2012/10/16 06:00 [pubmed]
PHST- 2013/11/20 06:00 [medline]
AID - 10.1111/j.1748-720X.2012.00684.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2012 Fall;40(3):523-5. doi: 10.1111/j.1748-720X.2012.00684.x.


PMID- 23061544
OWN - NLM
STAT- MEDLINE
DCOM- 20130205
LR  - 20181202
IS  - 1365-2044 (Electronic)
IS  - 0003-2409 (Linking)
VI  - 68
IP  - 1
DP  - 2013 Jan
TI  - Exploring laryngeal reflexes in anaesthetised children - the research ethics
      committee's point of view.
PG  - 5-6
LID - 10.1111/anae.12043 [doi]
FAU - Perruchoud, A P
AU  - Perruchoud AP
LA  - eng
PT  - Editorial
PT  - Comment
DEP - 20121012
PL  - England
TA  - Anaesthesia
JT  - Anaesthesia
JID - 0370524
RN  - 0 (Anesthetics, Local)
RN  - 98PI200987 (Lidocaine)
SB  - IM
CON - Anaesthesia. 2013 Jan;68(1):13-20. PMID: 23061716
CIN - Anaesthesia. 2013 May;68(5):532. PMID: 23573848
CIN - Anaesthesia. 2013 May;68(5):532-3. PMID: 23573849
CIN - Anaesthesia. 2013 May;68(5):533-4. PMID: 23573850
CIN - Anaesthesia. 2013 May;68(5):534-5. PMID: 23573851
CIN - Anaesthesia. 2013 May;68(5):535-6. PMID: 23573852
MH  - *Anesthesia, General
MH  - Anesthetics, Local/*therapeutic use
MH  - Female
MH  - Humans
MH  - Larynx/*drug effects
MH  - Lidocaine/*therapeutic use
MH  - Male
MH  - Reflex/*drug effects
MH  - Respiratory Mechanics/*drug effects
EDAT- 2012/10/16 06:00
MHDA- 2013/02/06 06:00
CRDT- 2012/10/16 06:00
PHST- 2012/10/16 06:00 [entrez]
PHST- 2012/10/16 06:00 [pubmed]
PHST- 2013/02/06 06:00 [medline]
AID - 10.1111/anae.12043 [doi]
PST - ppublish
SO  - Anaesthesia. 2013 Jan;68(1):5-6. doi: 10.1111/anae.12043. Epub 2012 Oct 12.


PMID- 23061273
OWN - NLM
STAT- MEDLINE
DCOM- 20121101
LR  - 20131106
IS  - 1351-5578 (Print)
IS  - 1351-5578 (Linking)
VI  - 20
IP  - 1
DP  - 2012
TI  - Investigating patients' experiences: methodological usefulness of interpretive
      interactionism.
PG  - 39-44
AB  - AIM: To demonstrate the methodological usefulness of interpretive interactionism 
      by applying it to the example of a study investigating healthcare experiences of 
      women affected by domestic violence. BACKGROUND: Understanding patients'
      experiences of health, illness and health care is important to nurses. For many
      years, biomedical discourse has prevailed in healthcare language and research,
      and has influenced healthcare responses. Contemporary nursing scholarship can be 
      developed by engaging with new ways of understanding therapeutic interactions
      with patients. Research that uses qualitative methods of inquiry is an important 
      paradigm for nurses who seek to explain and understand or describe experiences
      rather than predict outcomes. DISCUSSION: Interpretive interactionism is an
      interpretive form of inquiry for conducting studies of social or personal
      problems that have healthcare policy implications. It puts the patient at the
      centre of the research process and makes visible the experiences of patients as
      they interact with the healthcare and social systems that surround them.
      Interpretive interactionism draws on concepts of symbolic interactionism,
      phenomenology and hermeneutics. CONCLUSION: Interpretive interactionism is a
      patient-centred methodology that provides an alternative way of understanding
      patients' experiences. It can contribute to policy and practice development by
      drawing on the perspectives and experiences of patients, who are central to the
      research process. It also allows research findings to be situated in and linked
      to healthcare policy, professional ethics and organisational approaches to care. 
      IMPLICATIONS FOR RESEARCH/PRACTICE: Interpretive interactionism has
      methodological utility because it can contribute to policy and practice
      development by drawing on the perspectives and experiences of patients who are
      central to the research process. Interpretive interactionism allows research
      findings to be situated in and linked to health policy, professional ethics and
      organisational approaches to caring.
FAU - Tower, Marion
AU  - Tower M
AD  - School of Midwifery and Nursing, Griffith University, Nathan, Queensland,
      Australia. m.tower@griffith.edu.au
FAU - Rowe, Jennifer
AU  - Rowe J
FAU - Wallis, Marianne
AU  - Wallis M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurse Res
JT  - Nurse researcher
JID - 9435953
MH  - Battered Women/*psychology
MH  - Domestic Violence/*psychology
MH  - Female
MH  - Humans
MH  - *Nurse-Patient Relations
MH  - Nursing Methodology Research/*methods
MH  - Social Sciences/*methods
EDAT- 2012/10/16 06:00
MHDA- 2012/11/02 06:00
CRDT- 2012/10/16 06:00
PHST- 2012/10/16 06:00 [entrez]
PHST- 2012/10/16 06:00 [pubmed]
PHST- 2012/11/02 06:00 [medline]
AID - 10.7748/nr2012.09.20.1.39.c9307 [doi]
PST - ppublish
SO  - Nurse Res. 2012;20(1):39-44. doi: 10.7748/nr2012.09.20.1.39.c9307.


PMID- 23061082
OWN - NLM
STAT- MEDLINE
DCOM- 20121204
LR  - 20211021
IS  - 1203-6765 (Print)
IS  - 1203-6765 (Linking)
VI  - 17
IP  - 5
DP  - 2012 Sep-Oct
TI  - Myofascial pain in patients waitlisted for total knee arthroplasty.
PG  - 321-7
AB  - BACKGROUND: Knee pain is one of the major sources of pain and disability in
      developed countries, particularly in aging populations, and is the primary
      indication for total knee arthroplasty (TKA) in patients with osteoarthritis
      (OA). OBJECTIVES: To determine the presence of myofascial pain in OA patients
      waitlisted for TKA and to determine whether their knee pain may be alleviated by 
      trigger point injections. METHODS: Following ethics approval, 25 participants
      were recruited from the wait list for elective unilateral primary TKA at the
      study centre. After providing informed consent, all participants were examined
      for the presence of active trigger points in the muscles surrounding the knee and
      received trigger point injections of bupivacaine. Assessments and trigger point
      injections were implemented on the first visit and at subsequent visits on weeks 
      1, 2, 4 and 8. Outcome measures included the Timed Up and Go test, Brief Pain
      Inventory, Centre for Epidemiologic Studies Depression Scale, State-Trait Anxiety
      Inventory and Short-Form McGill Pain Questionnaire. RESULTS: Myofascial trigger
      points were identified in all participants. Trigger point injections
      significantly reduced pain intensity and pain interference, and improved
      mobility. All participants had trigger points identified in medial muscles, most 
      commonly in the head of the gastrocnemius muscle. An acute reduction in pain and 
      improved functionality was observed immediately following intervention, and
      persisted over the eight-week course of the investigation. CONCLUSION: All
      patients had trigger points in the vastus and gastrocnemius muscles, and 92% of
      patients experienced significant pain relief with trigger point injections at the
      first visit, indicating that a significant proportion of the OA knee pain was
      myofascial in origin. Further investigation is warranted to determine the
      prevalence of myofascial pain and whether treatment delays or prevents TKA.
FAU - Henry, Richard
AU  - Henry R
AD  - Department of Anesthsiology and Perioperative Medicine, Queen's University,
      Kingston, Ontario, Canada.
FAU - Cahill, Catherine Marie
AU  - Cahill CM
FAU - Wood, Gavin
AU  - Wood G
FAU - Hroch, Jennifer
AU  - Hroch J
FAU - Wilson, Rosemary
AU  - Wilson R
FAU - Cupido, Tracy
AU  - Cupido T
FAU - Vandenkerkhof, Elizabeth
AU  - Vandenkerkhof E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pain Res Manag
JT  - Pain research & management
JID - 9612504
RN  - Y8335394RO (Bupivacaine)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Arthroplasty, Replacement, Knee
MH  - Bupivacaine/*therapeutic use
MH  - Female
MH  - Humans
MH  - Injections, Intramuscular
MH  - Male
MH  - Middle Aged
MH  - Myofascial Pain Syndromes/complications/*drug therapy
MH  - Osteoarthritis, Knee/complications/*drug therapy
MH  - Pain Management
MH  - Pain Measurement
MH  - Treatment Outcome
MH  - Trigger Points
PMC - PMC3465092
EDAT- 2012/10/13 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/10/13 06:00
PHST- 2012/10/13 06:00 [entrez]
PHST- 2012/10/13 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1155/2012/547183 [doi]
PST - ppublish
SO  - Pain Res Manag. 2012 Sep-Oct;17(5):321-7. doi: 10.1155/2012/547183.


PMID- 23060323
OWN - NLM
STAT- MEDLINE
DCOM- 20130318
LR  - 20121012
IS  - 1740-7753 (Electronic)
IS  - 1740-7745 (Linking)
VI  - 9
IP  - 5
DP  - 2012 Oct
TI  - Eligibility criteria in randomized phase II and III adjuvant and neoadjuvant
      breast cancer trials: not a significant barrier to enrollment.
PG  - 652-9
LID - 10.1177/1740774512456453 [doi]
AB  - BACKGROUND: Clinical trial recruitment can be impeded by eligibility criteria
      being too numerous or too restrictive. PURPOSE: This study's principal objective 
      was to determine whether a specific category of eligibility criteria could be
      identified as a major barrier to patient enrollment. METHODS: Nine phase II or
      III clinical trials, opened between June 2004 and July 2008, were selected. A
      retrospective cohort of women diagnosed with invasive, nonmetastatic breast
      cancer and potentially eligible for these clinical trials was used. All
      eligibility criteria were sorted into the following categories: definition of
      disease, precision, safety, ethical and legal, or administrative. A total of 985 
      patient-trials were evaluated, defined as the experimental unit since one patient
      could be eligible to more than one trial. Proportions of cases with 'not met'
      eligibility criteria were assessed for each category in each trial. RESULTS: Two 
      clinical trials had a 'not met' subcategory criterion of over 20%. 'Pathology'
      and 'consent' subcategory criteria were 'not met' in 24.2% and 92.7% of cases for
      the NEOCAN and NCIC CTG MA.27 trials, respectively. NCIC CTG MA.27 had the
      highest proportion of 'not met' subcategory due to an inclusion criterion
      requiring participation to two companion studies. National Surgical Adjuvant
      Breast and Bowel Project (NSABP) B-38 had a proportion of 18.8% of cases 'not
      meeting' the receptor status subcategory criterion. All other subcategories of
      eligibility criteria assessed were 'not met' by less than 15% of patients.
      Overall, few subcategories had over 10% of ineligible patients. LIMITATIONS: Many
      eligibility criteria were considered 'nonevaluable' because the information
      evaluated would have required additional procedures not performed as part of the 
      general practice. CONCLUSION: The subjects from the study population are not
      precluded from entry in a trial because of stringent eligibility criteria.
      Eligibility criteria should reflect as much as possible the whole population to
      whom the treatment will be offered, with the exception of drugs targeting a
      specific receptor or pathway where only a subpopulation is hypothesized to
      benefit from the therapy. In the breast cancer clinical trials evaluated for the 
      present study, no criterion precluding recruitment was shared by many or all
      trials and no specific eligibility criterion was consistently the reason for
      patients' ineligibility.
FAU - Filion, Myriam
AU  - Filion M
AD  - Sante des populations: URESP, Centre de Recherche FRSQ du Centre Hospitalier
      Affilie Universitaire de Quebec, Quebec, QC, Canada.
FAU - Forget, Genevieve
AU  - Forget G
FAU - Brochu, Olyvia
AU  - Brochu O
FAU - Provencher, Louise
AU  - Provencher L
FAU - Desbiens, Christine
AU  - Desbiens C
FAU - Doyle, Catherine
AU  - Doyle C
FAU - Poirier, Brigitte
AU  - Poirier B
FAU - DuRocher, Martin
AU  - DuRocher M
FAU - Camden, Stephanie
AU  - Camden S
FAU - Lemieux, Julie
AU  - Lemieux J
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Trials
JT  - Clinical trials (London, England)
JID - 101197451
SB  - IM
MH  - Age Factors
MH  - Breast Neoplasms/*therapy
MH  - Clinical Trials, Phase II as Topic/*methods
MH  - Clinical Trials, Phase III as Topic/*methods
MH  - Female
MH  - Humans
MH  - Neoadjuvant Therapy/*methods
MH  - Neoplasm Staging
MH  - *Patient Selection
MH  - Randomized Controlled Trials as Topic/*methods
MH  - Retrospective Studies
EDAT- 2012/10/13 06:00
MHDA- 2013/03/19 06:00
CRDT- 2012/10/13 06:00
PHST- 2012/10/13 06:00 [entrez]
PHST- 2012/10/13 06:00 [pubmed]
PHST- 2013/03/19 06:00 [medline]
AID - 9/5/652 [pii]
AID - 10.1177/1740774512456453 [doi]
PST - ppublish
SO  - Clin Trials. 2012 Oct;9(5):652-9. doi: 10.1177/1740774512456453.


PMID- 23059848
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121015
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 5
DP  - 2012
TI  - A multimethod research investigation of consumer involvement in Australian health
      service accreditation programmes: the ACCREDIT-SCI study protocol.
LID - 10.1136/bmjopen-2012-002024 [doi]
LID - e002024 [pii]
AB  - INTRODUCTION: Health service accreditation programmes are a regulatory mechanism 
      adopted to drive improvements inpatient safety and quality. Research
      investigating the benefits or limitations, of consumer involvement in
      accreditation programmes is negligible. To develop our knowledge in this area the
      ACCREDIT collaboration (Accreditation Collaborative for the Conduct of Research, 
      Evaluation and Designated Investigations through Teamwork) has developed a
      research plan, known as the ACCREDIT-SCI (Standards of Consumer Involvement)
      study protocol. Two complementary studies have been designed: one, to examine the
      effectiveness of a standard for consumer participation and two, to explore how
      patient experiences vary across a range of settings with differing accreditation 
      results. METHODS AND DESIGN: The research setting is the Australian healthcare
      system, and the two studies focus on three accreditation programmes in the
      primary, acute and aged care domains. The studies will use multimethods: document
      analysis; interviews and surveys. Participants will be stakeholders across the
      three domains including: policy officers; frontline healthcare professionals;
      accreditation agency personnel, including surveyors and healthcare consumers.
      Drawing on previous experience, the research team has developed purpose-designed 
      tools. Data will be analysed using thematic, narrative and statistical
      (descriptive and inferential) procedures. ETHICS AND DISSEMINATION: The
      University of New South Wales Human Research Ethics Committee has approved the
      two studies (HREC 10274). Findings will be disseminated through seminars,
      conference presentations, academic publications and research partner websites.
      The findings will be formulated to facilitate uptake by policy and accreditation 
      agency professionals, researchers and academics, and consumers, nationally and
      internationally.
FAU - Greenfield, David
AU  - Greenfield D
AD  - Centre for Clinical Governance Research, Australian Institute of Health
      Innovation, University of New South Wales, Sydney, New South Wales, Australia.
FAU - Hinchcliff, Reece
AU  - Hinchcliff R
FAU - Moldovan, Max
AU  - Moldovan M
FAU - Mumford, Virginia
AU  - Mumford V
FAU - Pawsey, Marjorie
AU  - Pawsey M
FAU - Irene Westbrook, Johanna
AU  - Irene Westbrook J
FAU - Braithwaite, Jeffrey
AU  - Braithwaite J
LA  - eng
PT  - Journal Article
DEP - 20121010
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3488739
EDAT- 2012/10/13 06:00
MHDA- 2012/10/13 06:01
CRDT- 2012/10/13 06:00
PHST- 2012/10/13 06:00 [entrez]
PHST- 2012/10/13 06:00 [pubmed]
PHST- 2012/10/13 06:01 [medline]
AID - bmjopen-2012-002024 [pii]
AID - 10.1136/bmjopen-2012-002024 [doi]
PST - epublish
SO  - BMJ Open. 2012 Oct 10;2(5). pii: bmjopen-2012-002024. doi:
      10.1136/bmjopen-2012-002024. Print 2012.


PMID- 23059514
OWN - NLM
STAT- MEDLINE
DCOM- 20130322
LR  - 20151119
IS  - 1827-1596 (Electronic)
IS  - 0375-9393 (Linking)
VI  - 78
IP  - 10
DP  - 2012 Oct
TI  - Comparison of transpulmonary thermodilution, transthoracic echocardiography and
      conventional hemodynamic monitoring in neonates and infants after open heart
      surgery: a preliminary study.
PG  - 1101-8
AB  - BACKGROUND: Transpulmonary thermodilution (TPTD) is an increasingly popular
      method used to monitor the complex hemodynamic changes in critically ill
      children. The purpose of our study was to examine the relationship between
      transthoracic echocardiographic (TTE) parameters and global hemodynamic variables
      derived from TPTD and those derived from conventional measurements in infants and
      neonates undergoing corrective cardiac surgery. METHODS: After approval from the 
      Ethics Committee of Gottsegen Gyorgy Hungarian Institute of Cardiology and
      individual parental consent were obtained, patients were prospectively enrolled. 
      In parallel with continuous postoperative conventional monitoring, TPTD was
      measured four times daily, and TTE was performed once per day. Conventional
      hemodynamic, TPTD and TTE parameters were compared with weighted linear
      regression statistics and a Pearson correlation. RESULTS: One hundred forty-five 
      TPTD measurements and 35 TTE examinations of thirteen enrolled patients were
      analyzed. Global end-diastolic volume index (GEDVI) was correlated with the
      fractional shortening (SF, r=0.67, P=0.001) measured by TTE. Among the preload
      parameters, the percentage change of GEDVI between two consecutive time points
      showed a pertinent correlation with changes of cardiac index (r=0.67, P=0.001)
      and changes of stroke volume index (r=0.57, P=0.008). Percentage changes in SF
      demonstrated a strong negative correlation with changes of left ventricular
      end-systolic diameter (r=-0.86, P<0.001). There was no significant relationship
      between alterations in arterial or central venous pressure values with TTE or
      TPTD parameters. CONCLUSION: Both TPTD and TTE may be used in the estimating
      volumetric preload parameters. The time course of TPTD-derived parameters may
      have clinical relevance in pediatric critical care practice.
FAU - Gergely, M
AU  - Gergely M
AD  - Department of Anesthesiology and Intensive Therapy, Gottsegen Gyorgy Hungarian
      Institute of Cardiology, Budapest, Hungary.
FAU - Ablonczy, L
AU  - Ablonczy L
FAU - Kramer, S
AU  - Kramer S
FAU - Szekely, E A
AU  - Szekely EA
FAU - Sapi, E
AU  - Sapi E
FAU - Gal, J
AU  - Gal J
FAU - Szatmari, A
AU  - Szatmari A
FAU - Szekely, A
AU  - Szekely A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Italy
TA  - Minerva Anestesiol
JT  - Minerva anestesiologica
JID - 0375272
SB  - IM
MH  - Cardiac Surgical Procedures/*methods
MH  - Critical Care
MH  - Echocardiography/*methods
MH  - Female
MH  - Hemodynamics/*physiology
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Intensive Care, Neonatal
MH  - Male
MH  - Monitoring, Intraoperative/*methods
MH  - Regression Analysis
MH  - Thermodilution/*methods
MH  - Ventricular Function, Left
EDAT- 2012/10/13 06:00
MHDA- 2013/03/23 06:00
CRDT- 2012/10/13 06:00
PHST- 2012/10/13 06:00 [entrez]
PHST- 2012/10/13 06:00 [pubmed]
PHST- 2013/03/23 06:00 [medline]
AID - R02127713 [pii]
PST - ppublish
SO  - Minerva Anestesiol. 2012 Oct;78(10):1101-8.


PMID- 23059404
OWN - NLM
STAT- MEDLINE
DCOM- 20130826
LR  - 20130311
IS  - 1532-1932 (Electronic)
IS  - 1521-6934 (Linking)
VI  - 27
IP  - 2
DP  - 2013 Apr
TI  - The professional responsibility model of obstetric ethics and caesarean delivery.
PG  - 153-64
LID - 10.1016/j.bpobgyn.2012.09.001 [doi]
LID - S1521-6934(12)00142-3 [pii]
AB  - In this chapter, we provide an account of the professional responsibility model
      of obstetric ethics, and identify its implications for two major topics:
      patient-choice caesarean delivery and trial of labour after caesarean delivery.
      The professional responsibility model of obstetric ethics is based on the ethical
      concept of medicine as a profession and the ethical principles of beneficence and
      respect for autonomy. The obstetrician has beneficence-based and autonomy-based
      obligations to the pregnant woman and beneficence-based obligations to the fetus 
      when it is a patient. Because the viable fetus is a patient, the ethics of
      caesarean delivery requires balancing of obligations to the pregnant and fetal
      patient. The implication of the professional responsibility model for
      patient-choice caesarean delivery is that the obstetrician should respond to such
      requests with a recommendation against non-indicated caesarean delivery and for
      vaginal delivery. These recommendations should be explained and discussed in the 
      informed consent process. It is ethically permissible to implement an informed,
      reflective decision for non-indicated caesarean delivery. The implication for
      trial of labour after caesarean delivery is that, in settings properly equipped
      and staffed, the obstetrician should offer both trial of labour after caesarean
      delivery and planned caesarean delivery to women who have had one previous low
      transverse incision. The obstetrician should recommend against trial of labour
      after caesarean delivery for women with a previous classical incision.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Chervenak, Frank A
AU  - Chervenak FA
AD  - Department of Obstetrics and Gynecology, Weill Medical College of Cornell
      University, New York, USA. fac2001@med.cornell.edu
FAU - McCullough, Laurence B
AU  - McCullough LB
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121009
PL  - Netherlands
TA  - Best Pract Res Clin Obstet Gynaecol
JT  - Best practice & research. Clinical obstetrics & gynaecology
JID - 101121582
SB  - IM
MH  - Beneficence
MH  - Cesarean Section/*ethics/legislation & jurisprudence
MH  - Female
MH  - Humans
MH  - Informed Consent/ethics
MH  - Liability, Legal
MH  - Obstetrics/*ethics/legislation & jurisprudence
MH  - Patient Participation
MH  - Patient Preference
MH  - Personal Autonomy
MH  - Physician-Patient Relations/ethics
MH  - Pregnancy
MH  - Social Responsibility
MH  - Trial of Labor
MH  - United States
EDAT- 2012/10/13 06:00
MHDA- 2013/08/27 06:00
CRDT- 2012/10/13 06:00
PHST- 2012/07/10 00:00 [received]
PHST- 2012/09/03 00:00 [accepted]
PHST- 2012/10/13 06:00 [entrez]
PHST- 2012/10/13 06:00 [pubmed]
PHST- 2013/08/27 06:00 [medline]
AID - S1521-6934(12)00142-3 [pii]
AID - 10.1016/j.bpobgyn.2012.09.001 [doi]
PST - ppublish
SO  - Best Pract Res Clin Obstet Gynaecol. 2013 Apr;27(2):153-64. doi:
      10.1016/j.bpobgyn.2012.09.001. Epub 2012 Oct 9.


PMID- 23058865
OWN - NLM
STAT- MEDLINE
DCOM- 20130705
LR  - 20211021
IS  - 2385-2070 (Electronic)
IS  - 1723-2007 (Linking)
VI  - 11
IP  - 1
DP  - 2013 Jan
TI  - Ethical and deontological issues in Transfusion Medicine.
PG  - 14-25
LID - 10.2450/2012.0087-11 [doi]
FAU - Sacchini, Dario
AU  - Sacchini D
AD  - Institute of Bioethics, A Gemelli School of Medicine, Universita Cattolica del
      Sacro Cuore, Rome, Italy. dsacchini@rm.unicatt.it
FAU - Liumbruno, Giancarlo Maria
AU  - Liumbruno GM
FAU - Bruno, Gennaro
AU  - Bruno G
FAU - Liumbruno, Chiara
AU  - Liumbruno C
FAU - Rafanelli, Daniela
AU  - Rafanelli D
FAU - Minacori, Roberta
AU  - Minacori R
FAU - Refolo, Pietro
AU  - Refolo P
FAU - Spagnolo, Antonio G
AU  - Spagnolo AG
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Review
DEP - 20120919
PL  - Italy
TA  - Blood Transfus
JT  - Blood transfusion = Trasfusione del sangue
JID - 101237479
SB  - IM
MH  - Blood Transfusion/*ethics/history
MH  - *Ethical Theory
MH  - *Ethics, Medical
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
PMC - PMC3557472
EDAT- 2012/10/13 06:00
MHDA- 2013/07/06 06:00
CRDT- 2012/10/13 06:00
PHST- 2011/08/03 00:00 [received]
PHST- 2011/08/24 00:00 [accepted]
PHST- 2012/10/13 06:00 [entrez]
PHST- 2012/10/13 06:00 [pubmed]
PHST- 2013/07/06 06:00 [medline]
AID - 2012.0087-11 [pii]
AID - 10.2450/2012.0087-11 [doi]
PST - ppublish
SO  - Blood Transfus. 2013 Jan;11(1):14-25. doi: 10.2450/2012.0087-11. Epub 2012 Sep
      19.


PMID- 23057987
OWN - NLM
STAT- MEDLINE
DCOM- 20130405
LR  - 20121012
IS  - 1369-1627 (Electronic)
IS  - 0954-0261 (Linking)
VI  - 24
IP  - 5
DP  - 2012 Oct
TI  - Community mental health services for the mentally ill: practices and ethics.
PG  - 504-10
LID - 10.3109/09540261.2012.712953 [doi]
AB  - BACKGROUND: Approximately 54 million people around the world suffer from severe
      mental disorders such as schizophrenia and bipolar affective disorder
      (manic-depressive illness). In addition, 154 million people suffer from
      depression. Globally, progressive reforms have determined the changes in the
      provision of mental health services, with the current emphasis on community
      orientated care. OBJECTIVE: This paper focuses on the strategies in use in
      developing countries and enlisting interventions in high resource settings. The
      ethics of community interventions are highlighted. METHODS: English language
      literature on the subject was obtained thorough searches in PubMed, other indexed
      journals and published books. Results. Literature indicates the heterogeneity of 
      the community programmes. While abundant literature exists on ethics in research,
      the ethical issues of community-based mental health intervention has not been
      widely dealt with. CONCLUSION: Community care is emerging globally as an
      important method of service provision. While obstacles in varying forms remain,
      the benefits are gradually becoming visible. Mental health services can develop
      effectively if there is adherence to a principle ethical base, which respects the
      human rights of individuals living with mental illness.
FAU - Padmavati, Ramachandran
AU  - Padmavati R
AD  - Schizophrenia Research Foundation Chennai, India. padmavati@scarfi ndia.org
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Int Rev Psychiatry
JT  - International review of psychiatry (Abingdon, England)
JID - 8918131
SB  - IM
MH  - *Community Mental Health Services
MH  - Developing Countries
MH  - Humans
MH  - Mental Disorders/*rehabilitation
EDAT- 2012/10/13 06:00
MHDA- 2013/04/06 06:00
CRDT- 2012/10/13 06:00
PHST- 2012/10/13 06:00 [entrez]
PHST- 2012/10/13 06:00 [pubmed]
PHST- 2013/04/06 06:00 [medline]
AID - 10.3109/09540261.2012.712953 [doi]
PST - ppublish
SO  - Int Rev Psychiatry. 2012 Oct;24(5):504-10. doi: 10.3109/09540261.2012.712953.


PMID- 23057970
OWN - NLM
STAT- MEDLINE
DCOM- 20131031
LR  - 20191210
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 146
IP  - 3
DP  - 2013 Apr 25
TI  - Psychosocial work factors, major depressive and generalised anxiety disorders:
      results from the French national SIP study.
PG  - 319-27
LID - 10.1016/j.jad.2012.09.014 [doi]
LID - S0165-0327(12)00642-8 [pii]
AB  - BACKGROUND: Anxiety and depression are prevalent mental disorders in working
      populations. The risk factors of these disorders are not completely well known.
      Developing knowledge on occupational risk factors for mental disorders appears
      crucial. This study investigates the association between various classical and
      emergent psychosocial work factors and major depressive and generalised anxiety
      disorders in the French working population. METHODS: The study was based on a
      national random sample of 3765 men and 3944 women of the French working
      population (SIP 2006 survey). Major Depressive Disorder (MDD) and Generalised
      Anxiety Disorder (GAD) were measured using a standardised diagnostic interview
      (MINI). Occupational factors included psychosocial work factors as well as
      biomechanical, physical, and chemical exposures. Adjustment variables included
      age, occupation, marital status, social support, and life events. Multivariate
      analysis was performed using logistic regression analysis. RESULTS: Low decision 
      latitude, overcommitment, and emotional demands were found to be risk factors for
      both MDD-GAD among both genders. Other risk factors were observed: high
      psychological demands, low reward, ethical conflict, and job insecurity, but
      differences were found according to gender and outcome. Significant interaction
      terms were observed suggesting that low decision latitude, high psychological
      demands, and job insecurity had stronger effects on mental disorders for men than
      for women. LIMITATIONS: Given the cross-sectional study design, no causal
      conclusion could be drawn. CONCLUSIONS: This study showed significant
      associations between classical and emergent psychosocial work factors and
      MDD-GAD. Preventive actions targeting various psychosocial work factors,
      including emergent factors, may help to reduce mental disorders at the workplace.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Murcia, Marie
AU  - Murcia M
AD  - INSERM, U1018, CESP Centre for Research in Epidemiology and Population Health,
      Epidemiology of Occupational and Social Determinants of Health Team, Villejuif,
      France. murcia.evrest@yahoo.fr
FAU - Chastang, Jean-Francois
AU  - Chastang JF
FAU - Niedhammer, Isabelle
AU  - Niedhammer I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121008
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
SB  - IM
MH  - Adult
MH  - Anxiety Disorders/*epidemiology
MH  - Conflict, Psychological
MH  - Cross-Sectional Studies
MH  - Depressive Disorder, Major/*epidemiology
MH  - Female
MH  - France/epidemiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Occupational Diseases/*epidemiology
MH  - Risk Factors
MH  - Social Support
MH  - Socioeconomic Factors
MH  - Stress, Psychological/*psychology
MH  - Work/*psychology/statistics & numerical data
MH  - Workplace/psychology
EDAT- 2012/10/13 06:00
MHDA- 2013/11/01 06:00
CRDT- 2012/10/13 06:00
PHST- 2012/05/14 00:00 [received]
PHST- 2012/09/13 00:00 [revised]
PHST- 2012/09/15 00:00 [accepted]
PHST- 2012/10/13 06:00 [entrez]
PHST- 2012/10/13 06:00 [pubmed]
PHST- 2013/11/01 06:00 [medline]
AID - S0165-0327(12)00642-8 [pii]
AID - 10.1016/j.jad.2012.09.014 [doi]
PST - ppublish
SO  - J Affect Disord. 2013 Apr 25;146(3):319-27. doi: 10.1016/j.jad.2012.09.014. Epub 
      2012 Oct 8.


PMID- 23057599
OWN - NLM
STAT- MEDLINE
DCOM- 20140430
LR  - 20191210
IS  - 1471-6712 (Electronic)
IS  - 0283-9318 (Linking)
VI  - 27
IP  - 4
DP  - 2013 Dec
TI  - Validation of Karolinska Exhaustion Scale: psychometric properties of a measure
      of exhaustion syndrome.
PG  - 1010-7
LID - 10.1111/j.1471-6712.2012.01089.x [doi]
AB  - BACKGROUND: The syndrome of exhaustion is currently a medical diagnosis in
      Sweden. The description of the syndrome largely corresponds to the suggested core
      component of burnout, that is exhaustion. Karolinska Exhaustion Scale (KES) has
      been constructed to provide specific assessment of exhaustion in clinical and
      research settings. AIM: The purpose of the present study was to examine the
      psychometric properties of this scale in its original and revised versions by
      examining the factorial structure and measures of convergent and discriminant
      validity. METHODS: Data gathered from two independent samples (n1 = 358 & n2 =
      403) consisting of patients diagnosed with 'reaction to severe stress, and
      adjustment disorder' were subjected to confirmatory factor analysis. The study's 
      instruments were Karolinska Exhaustion Scale and Shirom Melam Burnout Measure.
      Correlation analyses were employed to follow up the established factorial
      structure of the scale. The study was ethically approved by Karolinska Institute 
      regional ethic committee. RESULTS: The findings demonstrated adequate fit of the 
      data to the measurement model provided by the revised version of KES Limitations:
      The main limitation of the present study is the lack of a gold standard of
      exhaustion for direct comparison with KES. (KES-26) and partially supported
      convergent validity and discriminant validity of the scale. CONCLUSION: The
      demonstrated psychometric properties of KES-26 indicate sound construct validity 
      for this scale encouraging use of this scale in assessment of exhaustion. The
      factorial structure of KES-26 may also be used to provide information concerning 
      possible different clinical profiles.
CI  - (c) 2012 The Authors Scandinavian Journal of Caring Sciences (c) 2012 Nordic
      College of Caring Science.
FAU - Saboonchi, Fredrik
AU  - Saboonchi F
AD  - Stress Research Institute, University of Stockholm, Stockholm, Sweden; Red Cross 
      University College, Stockholm, Sweden; Department of Clinical Sciences,
      Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden; Department of
      Clinical Neurosciences, Division of Insurance Medicine, Karolinska Institutet,
      Stockholm, Sweden.
FAU - Perski, Aleksander
AU  - Perski A
FAU - Grossi, Giorgio
AU  - Grossi G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20121012
PL  - Sweden
TA  - Scand J Caring Sci
JT  - Scandinavian journal of caring sciences
JID - 8804206
MH  - Adult
MH  - *Burnout, Professional
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Psychometrics
MH  - Sweden
MH  - Young Adult
OTO - NOTNLM
OT  - assessment
OT  - clinical burnout
OT  - confirmatory factor analysis
OT  - disturbed sleep
OT  - syndrome of exhaustion
EDAT- 2012/10/13 06:00
MHDA- 2014/05/03 06:00
CRDT- 2012/10/13 06:00
PHST- 2012/04/19 00:00 [received]
PHST- 2012/08/20 00:00 [accepted]
PHST- 2012/10/13 06:00 [entrez]
PHST- 2012/10/13 06:00 [pubmed]
PHST- 2014/05/03 06:00 [medline]
AID - 10.1111/j.1471-6712.2012.01089.x [doi]
PST - ppublish
SO  - Scand J Caring Sci. 2013 Dec;27(4):1010-7. doi: 10.1111/j.1471-6712.2012.01089.x.
      Epub 2012 Oct 12.


PMID- 23057560
OWN - NLM
STAT- MEDLINE
DCOM- 20141006
LR  - 20140117
IS  - 1365-2788 (Electronic)
IS  - 0964-2633 (Linking)
VI  - 58
IP  - 3
DP  - 2014 Mar
TI  - The human degree of care. Professional loving care for people with a mild
      intellectual disability: an explorative study.
PG  - 221-32
LID - 10.1111/j.1365-2788.2012.01638.x [doi]
AB  - BACKGROUND: Research has shown that care staff are not always able to offer
      quality care. Commercialisation and market forces within the care sector are
      often pointed to as an explanation for this shortcoming. In the present study,
      insight is gained into the possible connections between the commercialisation of 
      care, on the one hand, and the shrinkage of possibilities and motivation to offer
      professional loving care, on the other hand, from the perspective of care staff
      working with people with mild intellectual disabilities. METHOD: Semi-structured 
      qualitative interviews were conducted with 28 care staff working with people with
      mild intellectual disabilities. Scientific research methods were combined with
      normative ethical reflection to examine the internal morals of the care staff.
      RESULTS: According to participating care staff, an affiliation with and
      recognition of the client form the basis for professional loving care. Care staff
      recognise that their profession is increasingly being built upon manageability
      and accountability, and this is making their jobs more difficult. CONCLUSION: We 
      conclude that care staff perceive the precedence given to the smooth running of
      production processes over investment in direct contact with clients to be a real 
      threat to the quality of care. Concerns about declining motivation and loss of
      work satisfaction as a result of the commercialisation of care are only partly
      acknowledged by care staff. While shrinkage of space for professional loving care
      is recognised, one can hardly speak of declining motivation.
CI  - (c) 2012 The Authors. Journal of Intellectual Disability Research (c) 2012 John
      Wiley & Sons Ltd, MENCAP & IASSIDD.
FAU - Hermsen, M A
AU  - Hermsen MA
AD  - Tranzo, Tilburg School of Social and Behavioral Sciences, Tilburg, The
      Netherlands; Kennisn@ Dichterbij, Ottersum, The Netherlands.
FAU - Embregts, P J C M
AU  - Embregts PJ
FAU - Hendriks, A H C
AU  - Hendriks AH
FAU - Frielink, N
AU  - Frielink N
LA  - eng
PT  - Journal Article
DEP - 20121012
PL  - England
TA  - J Intellect Disabil Res
JT  - Journal of intellectual disability research : JIDR
JID - 9206090
SB  - IM
MH  - Adult
MH  - Attitude of Health Personnel
MH  - Caregivers/ethics/*psychology
MH  - Community Health Services/economics/*standards
MH  - Delivery of Health Care/economics
MH  - Female
MH  - Health Care Sector/economics/trends
MH  - Humans
MH  - Intellectual Disability/*nursing
MH  - Male
MH  - Marketing/economics/trends
MH  - Middle Aged
MH  - Pilot Projects
MH  - Severity of Illness Index
MH  - Young Adult
OTO - NOTNLM
OT  - commercialisation of care
OT  - motivation
OT  - professional loving care
OT  - quality care
OT  - staff-client relationship
EDAT- 2012/10/13 06:00
MHDA- 2014/10/07 06:00
CRDT- 2012/10/13 06:00
PHST- 2012/09/05 00:00 [accepted]
PHST- 2012/10/13 06:00 [entrez]
PHST- 2012/10/13 06:00 [pubmed]
PHST- 2014/10/07 06:00 [medline]
AID - 10.1111/j.1365-2788.2012.01638.x [doi]
PST - ppublish
SO  - J Intellect Disabil Res. 2014 Mar;58(3):221-32. doi:
      10.1111/j.1365-2788.2012.01638.x. Epub 2012 Oct 12.


PMID- 23057386
OWN - NLM
STAT- MEDLINE
DCOM- 20121101
LR  - 20191112
IS  - 1020-3397 (Print)
IS  - 1020-3397 (Linking)
VI  - 18
IP  - 9
DP  - 2012 Sep
TI  - Knowledge, perceptions and practices towards medical ethics among physician
      residents of University of Alexandria Hospitals, Egypt.
PG  - 935-45
AB  - This cross-sectional study was conducted to assess the knowledge, perceptions and
      practices towards medical ethics of physician residents at university hospitals
      in Alexandria, Egypt. A self-administered structured questionnaire was used for
      knowledge and perceptions and a checklist for observations of doctor-patient
      interactions in the outpatient setting. Only 18.0% ofthe 128 participating
      residents had obtained their knowledge from their medical education and 29.9%
      were dissatisfied with the roles played by the ethics committee. Most of the
      residents had satisfactory knowledge and 60.2% had satisfactory perceptions
      regarding ethical issues. The lowest perception score was in the domain of
      disclosing medical errors. Only 48.0% of the residents were compliant with the
      principles of medical ethics in practice and 52.0% of patients were dissatisfied 
      with their treating physicians. The study identified areas of unsatisfactory
      knowledge and practices towards ethical issues so as to devise means to sensitize
      residents to these issues and train them appropriately.
FAU - Mohamed, A M
AU  - Mohamed AM
AD  - Department of Community Medicine, Faculty of Medicine, University of Alexandria, 
      Alexandria, Egypt. aida_mohey@yahoo.com
FAU - Ghanem, M A
AU  - Ghanem MA
FAU - Kassem, A
AU  - Kassem A
LA  - eng
PT  - Journal Article
PL  - Egypt
TA  - East Mediterr Health J
JT  - Eastern Mediterranean health journal = La revue de sante de la Mediterranee
      orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit
JID - 9608387
SB  - IM
MH  - Adult
MH  - Attitude of Health Personnel
MH  - Confidentiality/ethics
MH  - Consumer Behavior
MH  - Cross-Sectional Studies
MH  - Disclosure/ethics
MH  - Egypt
MH  - Ethics Committees/organization & administration
MH  - Ethics, Medical/*education
MH  - Female
MH  - Guideline Adherence/statistics & numerical data
MH  - *Health Knowledge, Attitudes, Practice
MH  - *Hospitals, University
MH  - Humans
MH  - Internship and Residency/*organization & administration
MH  - Male
MH  - Middle Aged
MH  - Patient Rights/ethics
MH  - Physician-Patient Relations/ethics
MH  - Practice Guidelines as Topic
MH  - Socioeconomic Factors
MH  - Surveys and Questionnaires
EDAT- 2012/10/13 06:00
MHDA- 2012/11/02 06:00
CRDT- 2012/10/13 06:00
PHST- 2012/10/13 06:00 [entrez]
PHST- 2012/10/13 06:00 [pubmed]
PHST- 2012/11/02 06:00 [medline]
AID - 10.26719/2012.18.9.935 [doi]
PST - ppublish
SO  - East Mediterr Health J. 2012 Sep;18(9):935-45. doi: 10.26719/2012.18.9.935.


PMID- 23057371
OWN - NLM
STAT- MEDLINE
DCOM- 20121101
LR  - 20220408
IS  - 1020-3397 (Print)
IS  - 1020-3397 (Linking)
VI  - 18
IP  - 8
DP  - 2012 Aug
TI  - Problems and perceived needs for medical ethics education of resident physicians 
      in Alexandria teaching hospitals, Egypt.
PG  - 827-35
AB  - There is a call for greater preparation for the ethical challenges encountered by
      physicians in their future professional duties. This study in Egypt aimed to
      reveal problems and perceived needs for medical ethics education of resident
      physicians working at University of Alexandria hospitals. In a descriptive,
      cross-sectional survey, 128 residents answered a self-administered questionnaire.
      More than half were of the opinion that their medical ethics course was
      ineffective; 56.3% mentioned poor curricular planning. The majority complained
      that the subject was not tailored to specialties, the course was too short, there
      was a shortage of resources to facilitate the educational process and that
      assessment was done for knowledge but not for skills. Problems related to
      staffing were low staff:student ratios and staff lack of experience. Trainees,
      regardless of clinical discipline, felt that there was a great need for
      improvement to their medicalethics education.
FAU - Mohamed, A M
AU  - Mohamed AM
AD  - Department of Community Medicine, Faculty of Medicine, University of Alexandria, 
      Alexandria, Egypt. aida_mohey@yahoo.com
FAU - Ghanem, M A
AU  - Ghanem MA
FAU - Kassem, A
AU  - Kassem A
LA  - eng
PT  - Journal Article
PL  - Egypt
TA  - East Mediterr Health J
JT  - Eastern Mediterranean health journal = La revue de sante de la Mediterranee
      orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit
JID - 9608387
SB  - IM
MH  - Cross-Sectional Studies
MH  - Egypt
MH  - Ethics, Medical/*education
MH  - Female
MH  - *Hospitals, Teaching
MH  - Humans
MH  - Internship and Residency/*organization & administration
MH  - Male
MH  - Medicine
MH  - Needs Assessment
MH  - Teaching/methods
MH  - Time Factors
EDAT- 2012/10/13 06:00
MHDA- 2012/11/02 06:00
CRDT- 2012/10/13 06:00
PHST- 2012/10/13 06:00 [entrez]
PHST- 2012/10/13 06:00 [pubmed]
PHST- 2012/11/02 06:00 [medline]
AID - 10.26719/2012.18.8.827 [doi]
PST - ppublish
SO  - East Mediterr Health J. 2012 Aug;18(8):827-35. doi: 10.26719/2012.18.8.827.


PMID- 23057370
OWN - NLM
STAT- MEDLINE
DCOM- 20121101
LR  - 20191112
IS  - 1020-3397 (Print)
IS  - 1020-3397 (Linking)
VI  - 18
IP  - 8
DP  - 2012 Aug
TI  - Pharmaceutical representatives' beliefs and practices about their professional
      practice: a study in Sudan.
PG  - 821-6
AB  - Pharmaceutical representatives are an important promotional tool for
      pharmaceutical companies. This cross-sectional, exploratory study aimed to
      determine pharmaceutical representatives' beliefs and practices about their
      professional practice in Sudan. A random sample of 160 pharmaceutical
      representatives were interviewed using a pretested questionnaire. The majority
      were male (84.4%) and had received training in professional sales skills (86.3%) 
      and about the products being promoted (82.5%). Only 65.6% agreed that they
      provided full and balanced information about products. Not providing balanced
      information was attributed by 23.1% to doctors' lack of time. However, 28.1%
      confessed they sometimes felt like hiding unfavourable information, 21.9% were
      sometimes or always inclined to give untrue information to make sales and 66.9%
      considered free gifts as ethically acceptable. More attention is needed to
      dissemination of ethical codes of conduct and training about the ethics of drug
      promotion for pharmaceutical representatives in Sudan.
FAU - Idris, K M
AU  - Idris KM
AD  - Faculty of Pharmacy, University of Gezira, Wad Madani, Sudan.
FAU - Mustafa, A F
AU  - Mustafa AF
FAU - Yousif, M A
AU  - Yousif MA
LA  - eng
PT  - Journal Article
PL  - Egypt
TA  - East Mediterr Health J
JT  - Eastern Mediterranean health journal = La revue de sante de la Mediterranee
      orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit
JID - 9608387
SB  - IM
MH  - Adult
MH  - Cross-Sectional Studies
MH  - Disclosure
MH  - Drug Industry/economics/ethics/*organization & administration
MH  - Female
MH  - Humans
MH  - Interprofessional Relations
MH  - Male
MH  - Marketing of Health Services/ethics/*organization & administration
MH  - Middle Aged
MH  - Professional Practice/economics/ethics/*organization & administration
MH  - Sudan
EDAT- 2012/10/13 06:00
MHDA- 2012/11/02 06:00
CRDT- 2012/10/13 06:00
PHST- 2012/10/13 06:00 [entrez]
PHST- 2012/10/13 06:00 [pubmed]
PHST- 2012/11/02 06:00 [medline]
AID - 10.26719/2012.18.8.821 [doi]
PST - ppublish
SO  - East Mediterr Health J. 2012 Aug;18(8):821-6. doi: 10.26719/2012.18.8.821.


PMID- 23057010
OWN - NLM
STAT- MEDLINE
DCOM- 20131211
LR  - 20211021
IS  - 2235-2988 (Electronic)
IS  - 2235-2988 (Linking)
VI  - 2
DP  - 2012
TI  - An objective approach for Burkholderia pseudomallei strain selection as challenge
      material for medical countermeasures efficacy testing.
PG  - 120
LID - 10.3389/fcimb.2012.00120 [doi]
AB  - Burkholderia pseudomallei is the causative agent of melioidosis, a rare disease
      of biodefense concern with high mortality and extreme difficulty in treatment. No
      human vaccines are available that protect against B. pseudomallei infection, and 
      with the current limitations of antibiotic treatment, the development of new
      preventative and therapeutic interventions is crucial. Although clinical trials
      could be used to test the efficacy of new medical countermeasures (MCMs), the
      high mortality rates associated with melioidosis raises significant ethical
      issues concerning treating individuals with new compounds with unknown
      efficacies. The US Food and Drug Administration (FDA) has formulated a set of
      guidelines for the licensure of new MCMs to treat diseases in which it would be
      unethical to test the efficacy of these drugs in humans. The FDA "Animal Rule" 21
      CFR 314 calls for consistent, well-characterized B. pseudomallei strains to be
      used as challenge material in animal models. In order to facilitate the efficacy 
      testing of new MCMs for melioidosis using animal models, we intend to develop a
      well-characterized panel of strains for use. This panel will comprise of strains 
      that were isolated from human cases, have a low passage history, are virulent in 
      animal models, and are well-characterized phenotypically and genotypically. We
      have reviewed published and unpublished data on various B. pseudomallei strains
      to establish an objective method for selecting the strains to be included in the 
      panel of B. pseudomallei strains with attention to five categories: animal
      infection models, genetic characterization, clinical and passage history, and
      availability of the strain to the research community. We identified 109 strains
      with data in at least one of the five categories, scored each strain based on the
      gathered data and identified six strains as candidate for a B. pseudomallei
      strain panel.
FAU - Van Zandt, Kristopher E
AU  - Van Zandt KE
AD  - Battelle, Columbus OH, USA.
FAU - Tuanyok, Apichai
AU  - Tuanyok A
FAU - Keim, Paul S
AU  - Keim PS
FAU - Warren, Richard L
AU  - Warren RL
FAU - Gelhaus, H Carl
AU  - Gelhaus HC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120926
PL  - Switzerland
TA  - Front Cell Infect Microbiol
JT  - Frontiers in cellular and infection microbiology
JID - 101585359
SB  - IM
MH  - Animal Experimentation/*standards
MH  - Animals
MH  - Burkholderia pseudomallei/*isolation & purification/*pathogenicity
MH  - *Disease Models, Animal
MH  - Drug Approval
MH  - Guidelines as Topic
MH  - Humans
MH  - Melioidosis/*microbiology/*pathology
MH  - United States
PMC - PMC3458228
OTO - NOTNLM
OT  - aerosol
OT  - animal models
OT  - biodefense
OT  - genome
OT  - passage history
OT  - pseudomallei
OT  - sequencing
OT  - virulence
GN  - NLM: Original DateCompleted: 20121012
EDAT- 2012/10/12 06:00
MHDA- 2012/10/12 06:01
CRDT- 2012/10/12 06:00
PHST- 2012/06/05 00:00 [received]
PHST- 2012/08/29 00:00 [accepted]
PHST- 2012/10/12 06:00 [entrez]
PHST- 2012/10/12 06:00 [pubmed]
PHST- 2012/10/12 06:01 [medline]
AID - 10.3389/fcimb.2012.00120 [doi]
PST - epublish
SO  - Front Cell Infect Microbiol. 2012 Sep 26;2:120. doi: 10.3389/fcimb.2012.00120.
      eCollection 2012.


PMID- 23056380
OWN - NLM
STAT- MEDLINE
DCOM- 20130503
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 10
DP  - 2012
TI  - Background rates of adverse pregnancy outcomes for assessing the safety of
      maternal vaccine trials in sub-Saharan Africa.
PG  - e46638
LID - 10.1371/journal.pone.0046638 [doi]
AB  - BACKGROUND: Maternal immunization has gained traction as a strategy to diminish
      maternal and young infant mortality attributable to infectious diseases.
      Background rates of adverse pregnancy outcomes are crucial to interpret results
      of clinical trials in Sub-Saharan Africa. METHODS: We developed a mathematical
      model that calculates a clinical trial's expected number of neonatal and maternal
      deaths at an interim safety assessment based on the person-time observed during
      different risk windows. This model was compared to crude multiplication of the
      maternal mortality ratio and neonatal mortality rate by the number of live
      births. Systematic reviews of severe acute maternal morbidity (SAMM), low birth
      weight (LBW), prematurity, and major congenital malformations (MCM) in
      Sub-Saharan African countries were also performed. FINDINGS: Accounting for the
      person-time observed during different risk periods yields lower, more
      conservative estimates of expected maternal and neonatal deaths, particularly at 
      an interim safety evaluation soon after a large number of deliveries. Median
      incidence of SAMM in 16 reports was 40.7 (IQR: 10.6-73.3) per 1,000 total births,
      and the most common causes were hemorrhage (34%), dystocia (22%), and severe
      hypertensive disorders of pregnancy (22%). Proportions of liveborn infants who
      were LBW (median 13.3%, IQR: 9.9-16.4) or premature (median 15.4%, IQR:
      10.6-19.1) were similar across geographic region, study design, and institutional
      setting. The median incidence of MCM per 1,000 live births was 14.4 (IQR:
      5.5-17.6), with the musculoskeletal system comprising 30%. INTERPRETATION: Some
      clinical trials assessing whether maternal immunization can improve pregnancy and
      young infant outcomes in the developing world have made ethics-based decisions
      not to use a pure placebo control. Consequently, reliable background rates of
      adverse pregnancy outcomes are necessary to distinguish between vaccine benefits 
      and safety concerns. Local studies that quantify population-based background
      rates of adverse pregnancy outcomes will improve safety assessment of
      interventions during pregnancy.
FAU - Orenstein, Lauren A V
AU  - Orenstein LA
AD  - Emory University School of Medicine, Atlanta, Georgia, United States of America.
FAU - Orenstein, Evan W
AU  - Orenstein EW
FAU - Teguete, Ibrahima
AU  - Teguete I
FAU - Kodio, Mamoudou
AU  - Kodio M
FAU - Tapia, Milagritos
AU  - Tapia M
FAU - Sow, Samba O
AU  - Sow SO
FAU - Levine, Myron M
AU  - Levine MM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121004
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Vaccines)
SB  - IM
MH  - Africa South of the Sahara/epidemiology
MH  - Clinical Trials as Topic
MH  - Congenital Abnormalities/epidemiology
MH  - Female
MH  - Humans
MH  - Infant Mortality
MH  - Infant, Low Birth Weight/physiology
MH  - Infant, Newborn
MH  - Models, Theoretical
MH  - Pregnancy
MH  - Pregnancy Outcome/*epidemiology
MH  - Vaccines/*adverse effects
PMC - PMC3464282
EDAT- 2012/10/12 06:00
MHDA- 2013/05/04 06:00
CRDT- 2012/10/12 06:00
PHST- 2012/06/06 00:00 [received]
PHST- 2012/09/02 00:00 [accepted]
PHST- 2012/10/12 06:00 [entrez]
PHST- 2012/10/12 06:00 [pubmed]
PHST- 2013/05/04 06:00 [medline]
AID - 10.1371/journal.pone.0046638 [doi]
AID - PONE-D-12-16303 [pii]
PST - ppublish
SO  - PLoS One. 2012;7(10):e46638. doi: 10.1371/journal.pone.0046638. Epub 2012 Oct 4.


PMID- 23055775
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121012
LR  - 20220330
IS  - 1178-7090 (Electronic)
IS  - 1178-7090 (Linking)
VI  - 5
DP  - 2012
TI  - Tramadol/paracetamol fixed-dose combination in the treatment of moderate to
      severe pain.
PG  - 327-46
LID - 10.2147/JPR.S33112 [doi]
AB  - Pain is the most common reason patients seek medical attention and pain relief
      has been put forward as an ethical obligation of clinicians and a fundamental
      human right. However, pain management is challenging because the pathophysiology 
      of pain is complex and not completely understood. Widely used analgesics such as 
      nonsteroidal anti-inflammatory drugs (NSAIDs) and paracetamol (acetaminophen)
      have been associated with adverse events. Adverse event rates are of concern,
      especially in long-term treatment or at high doses. Paracetamol and NSAIDs are
      available by prescription, over the counter, and in combination preparations.
      Patients may be unaware of the risk associated with high dosages or long-term use
      of paracetamol and NSAIDs. Clinicians should encourage patients to disclose all
      medications they take in a "do ask, do tell" approach that includes patient
      education about the risks and benefits of common pain relievers. The ideal pain
      reliever would have few risks and enhanced analgesic efficacy. Fixed-dose
      combination analgesics with two or more agents may offer additive or synergistic 
      benefits to treat the multiple mechanisms of pain. Therefore, pain may be
      effectively treated while toxicity is reduced due to lower doses. One recent
      fixed-dose combination analgesic product combines tramadol, a centrally acting
      weak opioid analgesic, with low-dose paracetamol. Evidence-based guidelines
      recognize the potential value of combination analgesics in specific situations.
      The current guideline-based paradigm for pain treatment recommends NSAIDs for
      ongoing use with analgesics such as opioids to manage flares. However, the
      treatment model should evolve how to use low-dose combination products to manage 
      pain with occasional use of NSAIDs for flares to avoid long-term and high-dose
      treatment with these analgesics. A next step in pain management guidelines should
      be targeted therapy when possible, or low-dose combination therapy or both, to
      achieve maximal efficacy with minimal toxicity.
FAU - Pergolizzi, Joseph V Jr
AU  - Pergolizzi JV Jr
AD  - Department of Medicine, Johns Hopkins University, Baltimore, MD, USA ;
      Association of Chronic Pain Patients, Houston, TX, USA.
FAU - van de Laar, Mart
AU  - van de Laar M
FAU - Langford, Richard
AU  - Langford R
FAU - Mellinghoff, Hans-Ulrich
AU  - Mellinghoff HU
FAU - Merchante, Ignacio Moron
AU  - Merchante IM
FAU - Nalamachu, Srinivas
AU  - Nalamachu S
FAU - O'Brien, Joanne
AU  - O'Brien J
FAU - Perrot, Serge
AU  - Perrot S
FAU - Raffa, Robert B
AU  - Raffa RB
LA  - eng
PT  - Journal Article
DEP - 20120829
PL  - New Zealand
TA  - J Pain Res
JT  - Journal of pain research
JID - 101540514
PMC - PMC3442743
OTO - NOTNLM
OT  - NSAIDs
OT  - analgesics
OT  - combination analgesics
OT  - moderate pain
OT  - opioids
OT  - severe pain
OT  - tramadol/paracetamol
EDAT- 2012/10/12 06:00
MHDA- 2012/10/12 06:01
CRDT- 2012/10/12 06:00
PHST- 2012/10/12 06:00 [entrez]
PHST- 2012/10/12 06:00 [pubmed]
PHST- 2012/10/12 06:01 [medline]
AID - 10.2147/JPR.S33112 [doi]
AID - jpr-5-327 [pii]
PST - ppublish
SO  - J Pain Res. 2012;5:327-46. doi: 10.2147/JPR.S33112. Epub 2012 Aug 29.


PMID- 23055769
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121012
LR  - 20220408
IS  - 1178-7074 (Electronic)
IS  - 1178-7074 (Linking)
VI  - 5
DP  - 2012
TI  - Public knowledge of diabetes in Karen Ethnic rural residents: a community-based
      questionnaires study in the far north-west of Thailand.
PG  - 799-804
LID - 10.2147/IJGM.S33177 [doi]
AB  - BACKGROUND AND PURPOSE: The public knowledge of diabetes is important for
      prevention of disease. This study aimed to evaluate knowledge of diabetes, risk
      factors, and the common warning signs of diabetes and complications among
      community participants in a rural Karen ethnic community. METHODS: Participants
      were asked to answer a questionnaire regarding their knowledge of diabetes.
      Fasting blood glucose testing, blood pressure measurement, and body mass index
      (BMI) assessment were provided to the participants. The study was conducted at
      Thasongyang district, Tak province, Thailand. RESULTS: A total of 299 Karen rural
      residents were included in the study. The median age was 45 years and median
      fasting blood glucose was 88 mg/dL. The response rate to the questionnaires was
      91.97%. Half of the participants knew diabetes is a noncommunicable disease
      needing lifelong treatment. Overall, one-third of the community participants
      could correctly answer the knowledge assessment questions regarding risk factors 
      and common features of diabetes. whereas the other two-thirds either gave a wrong
      answer or were "not sure". Female participants had poorer diabetes knowledge than
      the males. CONCLUSION: The public knowledge of diabetes, as represented by this
      sample of the Karen ethic community, is alarmingly low. There is significant
      gender difference in knowledge level. Culturally tailored and gender-sensitive
      diabetes health education interventions are urgently needed in this minority
      ethnic community.
FAU - Lorga, Thaworn
AU  - Lorga T
AD  - Boromrajonani College of Nursing Nakhon Lampang (BCNLP), Lampang, Thailand.
FAU - Srithong, Kannapatch
AU  - Srithong K
FAU - Manokulanan, Pratumpan
AU  - Manokulanan P
FAU - Aung, Thin Nyein Nyein
AU  - Aung TN
FAU - Aung, Myo Nyein
AU  - Aung MN
LA  - eng
PT  - Journal Article
DEP - 20120927
PL  - New Zealand
TA  - Int J Gen Med
JT  - International journal of general medicine
JID - 101515487
PMC - PMC3468118
OTO - NOTNLM
OT  - Karen
OT  - diabetes
OT  - ethnic minority
OT  - gender differences
OT  - health education
EDAT- 2012/10/12 06:00
MHDA- 2012/10/12 06:01
CRDT- 2012/10/12 06:00
PHST- 2012/10/12 06:00 [entrez]
PHST- 2012/10/12 06:00 [pubmed]
PHST- 2012/10/12 06:01 [medline]
AID - 10.2147/IJGM.S33177 [doi]
AID - ijgm-5-799 [pii]
PST - ppublish
SO  - Int J Gen Med. 2012;5:799-804. doi: 10.2147/IJGM.S33177. Epub 2012 Sep 27.


PMID- 23055572
OWN - NLM
STAT- MEDLINE
DCOM- 20140424
LR  - 20211021
IS  - 1464-3790 (Electronic)
IS  - 0967-0742 (Linking)
VI  - 21
IP  - 3
DP  - 2013 Summer
TI  - Rhetoric or reality: what is the legal status of the consent form in
      health-related research?
PG  - 371-414
LID - 10.1093/medlaw/fws031 [doi]
AB  - This article addresses the unresolved conundrum of the legal status of consent
      forms used in research involving tissue samples or personal data. It identifies
      which rights participants might have by virtue of any consent form they have
      signed and which legal remedies might be available to them should the research
      depart from the terms of the original consent. The paper demonstrates that,
      although the legal status of consent forms is not clear in the UK, the landscape 
      is evolving. We suggest that the growing legal protection afforded to autonomy
      and judicial recognition of individual property rights in tissues may offer
      opportunities for remedies in law where the regulatory regimes controlling uses
      of human tissue and personal data do not. However, we argue that in the
      governance of research relationships-which depend crucially on trust-resort to
      legal remedy may be undesirable. We suggest that treating consent as a one-off
      event that can be effectively captured in a written document-as the law tends to 
      do-is an inappropriate and counter-productive approach. The aims of ethical
      research governance will be better served by seeing consent as continuing
      relational process, requiring on-going mutual respect, opportunity for
      communication, and accommodation of changing circumstances. The consent form is
      merely a framing instrument and only the starting point for a partnership that
      will evolve over time. Crucially, the limits of consent must be recognised in the
      design and governance of modern research practices. The article concludes with
      recommendations to reconceive consent in these terms.
FAU - Laurie, Graeme
AU  - Laurie G
AD  - School of Law, University of Edinburgh, Old College, South Bridge, Edinburgh EH8 
      9YL, UK. graeme.laurie@ed.ac.uk
FAU - Postan, Emily
AU  - Postan E
LA  - eng
GR  - 097093/Wellcome Trust/United Kingdom
GR  - WT097093MA/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Legal Case
PT  - Research Support, Non-U.S. Gov't
DEP - 20121010
PL  - England
TA  - Med Law Rev
JT  - Medical law review
JID - 9308945
SB  - IM
MH  - Biomedical Research/*legislation & jurisprudence
MH  - Clinical Trials as Topic
MH  - Consent Forms/*legislation & jurisprudence
MH  - Humans
MH  - Ownership/legislation & jurisprudence
MH  - Personal Autonomy
MH  - Research Subjects/*legislation & jurisprudence
MH  - Tissue Donors/legislation & jurisprudence
MH  - United Kingdom
PMC - PMC3746797
EDAT- 2012/10/12 06:00
MHDA- 2014/04/25 06:00
CRDT- 2012/10/12 06:00
PHST- 2012/10/12 06:00 [entrez]
PHST- 2012/10/12 06:00 [pubmed]
PHST- 2014/04/25 06:00 [medline]
AID - fws031 [pii]
AID - 10.1093/medlaw/fws031 [doi]
PST - ppublish
SO  - Med Law Rev. 2013 Summer;21(3):371-414. doi: 10.1093/medlaw/fws031. Epub 2012 Oct
      10.


PMID- 23055383
OWN - NLM
STAT- MEDLINE
DCOM- 20130307
LR  - 20191210
IS  - 0037-9085 (Print)
IS  - 0037-9085 (Linking)
VI  - 105
IP  - 5
DP  - 2012 Dec
TI  - [Perceptions of the practice of clinical trials on HIV/AIDS by medical
      prescribers of Kinshasa approving antiretrovirals (DR Congo)].
PG  - 406-11
LID - 10.1007/s13149-012-0263-8 [doi]
AB  - The purpose of this study, conducted between November 2005 and January 2006 among
      prescribers of antiretroviral drugs, was to identify their perceptions on the
      contextual issues related to the practice of the clinical trials on HIV/AIDS in
      Kinshasa. To perform the identification of these issues, a questionnaire was
      developed and finalized following the exploratory phase of our investigation to
      assess the views of the physicians on the national AIDS control program (PNLS) of
      Congo, which play the leading role in the context of their professional practice.
      Of 50 prescribers solicited to participate in our survey, 35 have returned the
      questionnaire, 10 were not available at the time of the survey and 5 have not
      returned the questionnaire to the address and within such period as we had
      indicated. The results reflect the need to strengthen the capacity-building of
      local actors. One of the objectives covered by the local conduct of clinical
      trials is the transfer of knowledge; it is necessary, in the light of the
      results, to say the educational role of the local Ethics Committee. This should
      allow the challenge of contextualization and reduce the tensions that could
      compromise the efficient conduct of clinical trials.
FAU - Lubangi, M M
AU  - Lubangi MM
AD  - Universite de Liege, Liege, Belgique. glubangi2002@yahoo.fr
FAU - Moutschen, M
AU  - Moutschen M
LA  - fre
PT  - Evaluation Study
PT  - Journal Article
TT  - Perceptions de la pratique des essais cliniques sur le VIH/sida par les medecins 
      prescripteurs des antiretroviraux agrees de Kinshasa (RD Congo).
DEP - 20121010
PL  - France
TA  - Bull Soc Pathol Exot
JT  - Bulletin de la Societe de pathologie exotique (1990)
JID - 9212564
RN  - 0 (Anti-Retroviral Agents)
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/*drug therapy/psychology
MH  - Anti-Retroviral Agents/*therapeutic use
MH  - Clinical Trials as Topic/methods/*statistics & numerical data
MH  - Data Collection
MH  - Democratic Republic of the Congo/epidemiology
MH  - Female
MH  - HIV Infections/*drug therapy/psychology
MH  - HIV-1/physiology
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Male
MH  - Perception/*physiology
MH  - Physicians/psychology
MH  - Practice Patterns, Physicians'/*statistics & numerical data
MH  - Professional Practice/statistics & numerical data
MH  - Surveys and Questionnaires
EDAT- 2012/10/12 06:00
MHDA- 2013/03/08 06:00
CRDT- 2012/10/12 06:00
PHST- 2011/05/04 00:00 [received]
PHST- 2012/08/07 00:00 [accepted]
PHST- 2012/10/12 06:00 [entrez]
PHST- 2012/10/12 06:00 [pubmed]
PHST- 2013/03/08 06:00 [medline]
AID - 10.1007/s13149-012-0263-8 [doi]
PST - ppublish
SO  - Bull Soc Pathol Exot. 2012 Dec;105(5):406-11. doi: 10.1007/s13149-012-0263-8.
      Epub 2012 Oct 10.


PMID- 23055290
OWN - NLM
STAT- MEDLINE
DCOM- 20130320
LR  - 20121011
IS  - 1468-3148 (Electronic)
IS  - 1360-2322 (Linking)
VI  - 25
IP  - 6
DP  - 2012 Nov
TI  - End-of-life care and dying: issues raised by staff supporting older people with
      intellectual disability in community living services.
PG  - 571-83
LID - 10.1111/jar.12000 [doi]
AB  - BACKGROUND: The aim of this study was to explore the current status of
      end-of-life care and dying of people with intellectual disability based on the
      experiences of staff in community living services. MATERIALS AND METHODS: Focus
      groups and individual interviews were conducted, guided by grounded theory
      methodology. RESULTS: The current status of end-of-life care and dying comprised 
      five key 'issues': knowledge of dying, ethical values, the where of caring, the
      how of caring and post-death caring. These issues occurred in relationship with
      'partners', including the dying person, other clients, fellow staff, family,
      external health services and the coroner. CONCLUSIONS: End-of-life care
      represents a complex interaction between the care issues and the partners
      involved in care. Despite this complexity, staff were committed to the provision 
      of end-of-life care.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Wiese, Michele
AU  - Wiese M
AD  - University of Sydney, Lidcombe, NSW, Australia. michele.wiese@sydney.edu.au
FAU - Stancliffe, Roger J
AU  - Stancliffe RJ
FAU - Balandin, Susan
AU  - Balandin S
FAU - Howarth, Glennys
AU  - Howarth G
FAU - Dew, Angela
AU  - Dew A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120921
PL  - England
TA  - J Appl Res Intellect Disabil
JT  - Journal of applied research in intellectual disabilities : JARID
JID - 9613616
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Attitude to Death
MH  - Australia
MH  - Bioethical Issues
MH  - Caregivers/ethics/psychology
MH  - Ethics, Medical
MH  - Female
MH  - Humans
MH  - Intellectual Disability/psychology/*rehabilitation
MH  - Male
MH  - Professional Practice/*standards
MH  - Professional-Family Relations
MH  - Professional-Patient Relations
MH  - Qualitative Research
MH  - Research Report
MH  - Terminal Care/ethics/methods/*standards
EDAT- 2012/10/12 06:00
MHDA- 2013/03/21 06:00
CRDT- 2012/10/12 06:00
PHST- 2012/05/14 00:00 [accepted]
PHST- 2012/10/12 06:00 [entrez]
PHST- 2012/10/12 06:00 [pubmed]
PHST- 2013/03/21 06:00 [medline]
AID - 10.1111/jar.12000 [doi]
PST - ppublish
SO  - J Appl Res Intellect Disabil. 2012 Nov;25(6):571-83. doi: 10.1111/jar.12000. Epub
      2012 Sep 21.


PMID- 23055128
OWN - NLM
STAT- MEDLINE
DCOM- 20130528
LR  - 20211021
IS  - 1543-0154 (Electronic)
IS  - 0885-8195 (Linking)
VI  - 27
IP  - 4
DP  - 2012 Dec
TI  - Shared decision making in cancer screening and treatment decisions for American
      Indian and Alaska native communities: can we ethically calibrate interventions to
      patients' values?
PG  - 790-2
LID - 10.1007/s13187-012-0412-6 [doi]
AB  - Shared decision making has been advocated as a key ethical strategy to improve
      quality of care and cancer control, especially in relation to screening and
      treatment decisions at various stages of the cancer continuum. Recent research on
      cancer in American Indian/Alaska Native (AI/AN) communities has highlighted
      significant disparities, raising questions about how best to implement prevention
      and screening programs in often fragmented and underfunded Indian health, tribal 
      and urban systems. Incorporating shared decision making initiatives routinely may
      provide opportunities to address the complex choices AI/AN patients face.
FAU - Nowakowski, Katherine E
AU  - Nowakowski KE
AD  - Mayo Medical School, Mayo Clinic, Rochester, MN 55905, USA.
FAU - Tilburt, Jon C
AU  - Tilburt JC
FAU - Kaur, Judith S
AU  - Kaur JS
LA  - eng
GR  - L60 MD003788/MD/NIMHD NIH HHS/United States
GR  - UL1 TR000135/TR/NCATS NIH HHS/United States
PT  - Journal Article
PL  - England
TA  - J Cancer Educ
JT  - Journal of cancer education : the official journal of the American Association
      for Cancer Education
JID - 8610343
SB  - IM
MH  - Alaska
MH  - Cultural Diversity
MH  - *Decision Making
MH  - Delivery of Health Care
MH  - Early Detection of Cancer/*psychology
MH  - Humans
MH  - Indians, North American/*psychology
MH  - Neoplasms/diagnosis/*prevention & control/psychology
MH  - Practice Patterns, Physicians'
MH  - *Quality of Health Care
PMC - PMC3518632
MID - NIHMS411383
EDAT- 2012/10/12 06:00
MHDA- 2013/05/29 06:00
CRDT- 2012/10/12 06:00
PHST- 2012/10/12 06:00 [entrez]
PHST- 2012/10/12 06:00 [pubmed]
PHST- 2013/05/29 06:00 [medline]
AID - 10.1007/s13187-012-0412-6 [doi]
PST - ppublish
SO  - J Cancer Educ. 2012 Dec;27(4):790-2. doi: 10.1007/s13187-012-0412-6.


PMID- 23055099
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130108
LR  - 20211021
IS  - 1868-310X (Print)
IS  - 1868-310X (Linking)
VI  - 4
IP  - 1
DP  - 2013 Jan
TI  - Screening criteria: the need to deal with new developments and ethical issues in 
      newborn metabolic screening.
PG  - 59-67
LID - 10.1007/s12687-012-0118-9 [doi]
AB  - Newborn metabolic screening is the most widespread application of screening
      technology and provides the most comprehensive application of genetics in health 
      services, where the Guthrie blood spot cards allow screening for metabolic
      diseases in close to 100 % of all newborn babies. Despite over 40 years of use
      and significant benefits to well in excess of 100,000 children worldwide, there
      is remarkably little consensus in what conditions should be screened for and
      response to new advances in medicine relating to programme expansion. In this
      article, the international criteria for newborn metabolic screening are
      considered, and we propose that these criteria are poorly developed in relation
      to the baby, its family and society as a whole. Additionally, the ethical issues 
      that should inform the application of screening criteria are often not developed 
      to a level where a consensus might easily be achieved. We also consider that when
      family interests are factored in to the decision-making process, they have a
      significant influence in determining the list of diseases in the panel, with
      countries or states incorporating family and societal values being the most
      responsive. Based on our analysis, we propose that decision criteria for
      metabolic screening in the newborn period should be adapted to specifically
      include parent and family interests, community values, patients' rights, duties
      of government and healthcare providers, and ethical arguments for action in the
      face of uncertainty.
FAU - Forman, John
AU  - Forman J
AD  - New Zealand Organisation for Rare Disorders (NZORD), PO Box 38-538, Wellington
      Mail Centre, 5045, Wellington, New Zealand, exec.director@nzord.org.nz.
FAU - Coyle, Fiona
AU  - Coyle F
FAU - Levy-Fisch, Jill
AU  - Levy-Fisch J
FAU - Roberts, Pat
AU  - Roberts P
FAU - Terry, Sharon
AU  - Terry S
FAU - Legge, Michael
AU  - Legge M
LA  - eng
PT  - Journal Article
DEP - 20121007
PL  - Germany
TA  - J Community Genet
JT  - Journal of community genetics
JID - 101551501
PMC - PMC3537969
EDAT- 2012/10/12 06:00
MHDA- 2012/10/12 06:01
CRDT- 2012/10/12 06:00
PHST- 2012/04/30 00:00 [received]
PHST- 2012/09/12 00:00 [accepted]
PHST- 2012/10/12 06:00 [entrez]
PHST- 2012/10/12 06:00 [pubmed]
PHST- 2012/10/12 06:01 [medline]
AID - 10.1007/s12687-012-0118-9 [doi]
PST - ppublish
SO  - J Community Genet. 2013 Jan;4(1):59-67. doi: 10.1007/s12687-012-0118-9. Epub 2012
      Oct 7.


PMID- 23054676
OWN - NLM
STAT- MEDLINE
DCOM- 20140122
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 3
DP  - 2013 Sep
TI  - Material scarcity: a reason for responsibility in technology development and
      product design.
PG  - 1165-79
LID - 10.1007/s11948-012-9401-8 [doi]
AB  - There are warning signs for impending scarcity of certain technology metals that 
      play a critical role in high-tech products. The scarce elements are indispensable
      for the design of modern technologies with superior performance. Material
      scarcity can restrain future innovations and presents therefore a serious risk
      that must be counteracted. However, the risk is often underrated in the pursuit
      of technological progress. Many innovators seem to be inattentive to the
      limitations in availability of critical resources and the possible implications
      thereof. The present shortages in industrial supply with technology metals may be
      interpreted as a wake-up call for technology developers to tackle the issue with 
      due consideration. The article reviews the materials scarcity phenomenon from the
      viewpoint of sustainable development ethics. The following questions are
      discussed: 'Should preventative actions be taken today in order to mitigate
      resource scarcity in future?' and 'Should technology developers feel responsible 
      to do this?' The discussion presents arguments for industrial designers and
      engineers to create a sense of responsibility for the proactive mitigation of
      material scarcity. Being protagonists of the innovation system, they have the
      opportunity to lead change towards resource-aware technology development. The
      paper concludes by outlining ideas on how they can pioneer sustainable management
      of critical materials.
FAU - Kohler, Andreas R
AU  - Kohler AR
AD  - Faculty of Industrial Design Engineering, Delft University of Technology, Delft, 
      The Netherlands. a.r.koehler@tudelft.nl
LA  - eng
PT  - Journal Article
DEP - 20121006
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
RN  - 0 (Metals)
SB  - IM
MH  - *Conservation of Natural Resources
MH  - Engineering/*ethics
MH  - Humans
MH  - Industry
MH  - *Metals
MH  - Risk
MH  - *Social Responsibility
MH  - Technology/*ethics
EDAT- 2012/10/12 06:00
MHDA- 2014/01/23 06:00
CRDT- 2012/10/12 06:00
PHST- 2012/02/01 00:00 [received]
PHST- 2012/09/18 00:00 [accepted]
PHST- 2012/10/12 06:00 [entrez]
PHST- 2012/10/12 06:00 [pubmed]
PHST- 2014/01/23 06:00 [medline]
AID - 10.1007/s11948-012-9401-8 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Sep;19(3):1165-79. doi: 10.1007/s11948-012-9401-8. Epub 2012
      Oct 6.


PMID- 23054675
OWN - NLM
STAT- MEDLINE
DCOM- 20140122
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 3
DP  - 2013 Sep
TI  - Failures in clinical trials in the European Union: lessons from the Polish
      experience.
PG  - 1087-98
LID - 10.1007/s11948-012-9400-9 [doi]
AB  - When discussing the safety of research subjects, including their exploitation and
      vulnerability as well as failures in clinical research, recent commentators have 
      focused mostly on countries with low or middle-income economies. High-income
      countries are seen as relatively safe and well-regulated. This article presents
      irregularities in clinical trials in an EU member state, Poland, which were
      revealed by the Supreme Audit Office of Poland (the NIK). Despite adopting many
      European Union regulations, including European Commission directives concerning
      Good Clinical Practice, these irregularities occurred. Causes as well as
      potential solutions to make clinical trials more ethical and safer are discussed.
FAU - Waligora, Marcin
AU  - Waligora M
AD  - Department of Philosophy and Bioethics, Jagiellonian University, Krakow, Poland. 
      m.waligora@uj.edu.pl
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121006
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Biomedical Research/*ethics/legislation & jurisprudence
MH  - European Union
MH  - *Guideline Adherence
MH  - Humans
MH  - *Patient Safety
MH  - Poland
MH  - *Research Subjects/legislation & jurisprudence
PMC - PMC3735958
EDAT- 2012/10/12 06:00
MHDA- 2014/01/23 06:00
CRDT- 2012/10/12 06:00
PHST- 2012/04/11 00:00 [received]
PHST- 2012/09/18 00:00 [accepted]
PHST- 2012/10/12 06:00 [entrez]
PHST- 2012/10/12 06:00 [pubmed]
PHST- 2014/01/23 06:00 [medline]
AID - 10.1007/s11948-012-9400-9 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Sep;19(3):1087-98. doi: 10.1007/s11948-012-9400-9. Epub 2012
      Oct 6.


PMID- 23054674
OWN - NLM
STAT- MEDLINE
DCOM- 20131112
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 18
IP  - 3
DP  - 2012 Sep
TI  - Editors' overview: Neuroethics: many voices and many stories.
PG  - 423-32
LID - 10.1007/s11948-012-9398-z [doi]
AB  - Advances in neuroscience continue to enhance understanding of the brain and
      provide new tools to take advantage of that understanding. These changes are
      poised to profoundly alter society. Given that the impact will be felt not only
      by neuroscientists, but by diverse members of society, it is imperative that
      conversations engage all stakeholders. Doing so will allow for the sharing of
      diverse views and perspectives to understand and frame the science, better
      educate and prepare the public for new developments, and provide a shared
      approach to identifying and resolving ethical challenges. These were the goals of
      Neuroethics Week, staged in 2007 by the Center for Ethics in Science and
      Technology in San Diego, and are the basis for the contributions to this special 
      issue of Science and Engineering Ethics.
FAU - Kalichman, Michael
AU  - Kalichman M
FAU - Plemmons, Dena
AU  - Plemmons D
FAU - Bird, Stephanie J
AU  - Bird SJ
LA  - eng
GR  - UL1 RR031980/RR/NCRR NIH HHS/United States
GR  - UL1 TR000100/TR/NCATS NIH HHS/United States
GR  - UL1 TR001442/TR/NCATS NIH HHS/United States
PT  - Editorial
PT  - Introductory Journal Article
DEP - 20120929
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Brain
MH  - Humans
MH  - *Morals
MH  - Neurosciences/*ethics
MH  - Science/*ethics
MH  - Technology/ethics
PMC - PMC3483404
MID - NIHMS411351
EDAT- 2012/10/12 06:00
MHDA- 2013/11/13 06:00
CRDT- 2012/10/12 06:00
PHST- 2012/08/06 00:00 [received]
PHST- 2012/08/20 00:00 [accepted]
PHST- 2012/10/12 06:00 [entrez]
PHST- 2012/10/12 06:00 [pubmed]
PHST- 2013/11/13 06:00 [medline]
AID - 10.1007/s11948-012-9398-z [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2012 Sep;18(3):423-32. doi: 10.1007/s11948-012-9398-z. Epub 2012 
      Sep 29.


PMID- 23054673
OWN - NLM
STAT- MEDLINE
DCOM- 20140122
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 3
DP  - 2013 Sep
TI  - Human enhancement and communication: on meaning and shared understanding.
PG  - 1039-56
LID - 10.1007/s11948-012-9395-2 [doi]
AB  - Our technologies have enabled us to change both the world and our perceptions of 
      the world, as well as to change ourselves and to find new ways to fulfil the
      human desire for improvement and for having new capacities. The debate around
      using technology for human enhancement has already raised many ethical concerns, 
      however little research has been done in how human enhancement can affect human
      communication. The purpose of this paper is to explore whether some human
      enhancements could change our shared lifeworld so radically that human
      communication as we know it would not be possible any longer. After exploring the
      kinds of communication problems we are concerned with as well as mentioning some 
      possible enhancement interventions that could bring about such problems, we will 
      address some of the ethical implications that follow from these potential
      communication problems. We argue that because of the role that communication
      plays in human society, this issue deserves attention.
FAU - Cabrera, Laura
AU  - Cabrera L
AD  - Institute of Biomedical Ethics, University of Basel, Basel, Switzerland.
      laura.cabrera@unibas.ch
FAU - Weckert, John
AU  - Weckert J
LA  - eng
PT  - Journal Article
DEP - 20121005
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Biomedical Enhancement/ethics
MH  - *Communication
MH  - Humans
MH  - Interpersonal Relations
MH  - *Technology/ethics
EDAT- 2012/10/12 06:00
MHDA- 2014/01/23 06:00
CRDT- 2012/10/12 06:00
PHST- 2012/06/18 00:00 [received]
PHST- 2012/08/20 00:00 [accepted]
PHST- 2012/10/12 06:00 [entrez]
PHST- 2012/10/12 06:00 [pubmed]
PHST- 2014/01/23 06:00 [medline]
AID - 10.1007/s11948-012-9395-2 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Sep;19(3):1039-56. doi: 10.1007/s11948-012-9395-2. Epub 2012
      Oct 5.


PMID- 23054671
OWN - NLM
STAT- MEDLINE
DCOM- 20131112
LR  - 20211203
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 18
IP  - 3
DP  - 2012 Sep
TI  - Neuroscience, neuropolitics and neuroethics: the complex case of crime, deception
      and FMRI.
PG  - 573-91
LID - 10.1007/s11948-012-9393-4 [doi]
AB  - Scientific developments take place in a socio-political context but scientists
      often ignore the ways their innovations will be both interpreted by the media and
      used by policy makers. In the rush to neuroscientific discovery important
      questions are overlooked, such as the ways: (1) the brain, environment and
      behavior are related; (2) biological changes are mediated by social organization;
      (3) institutional bias in the application of technical procedures ignores race,
      class and gender dimensions of society; (4) knowledge is used to the advantage of
      the powerful; and (5) its applications may reinforce existing structures of power
      that pose ethical questions about distributive justice. The case of crime,
      deception and functional Magnetic Resonance Imaging (fMRI) shows the complexity, 
      and the political and ethical challenges that confront those who seek to use
      neuroscience to explain the etiology of crime, and who base policy on its
      findings. An ethically grounded neuroscience needs to take account of existing
      structures of power and difference, and to develop a public neuropolitical
      consciousness that ensures that those subject to risk by the application of
      science and technology are participants in the decision-making processes
      involving the implementation of policies that affect them.
FAU - Henry, Stuart
AU  - Henry S
AD  - School of Public Affairs, San Diego State University, 5500 Campanile Dr., San
      Diego, CA 92182-4305, USA. stuart.henry2@gmail.com
FAU - Plemmons, Dena
AU  - Plemmons D
LA  - eng
PT  - Journal Article
DEP - 20120929
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
CIN - Sci Eng Ethics. 2012 Sep;18(3):593-600. PMID: 23001457
MH  - *Brain
MH  - *Crime
MH  - Criminal Law
MH  - Criminology/ethics
MH  - *Deception
MH  - Gender Identity
MH  - Humans
MH  - Magnetic Resonance Imaging/*ethics
MH  - Morals
MH  - Neurosciences/*ethics
MH  - Politics
MH  - *Psychophysiology
MH  - Public Policy
MH  - Racial Groups
MH  - Science/ethics
MH  - Social Behavior
MH  - Social Class
MH  - Social Environment
MH  - *Social Justice
MH  - Technology/ethics
EDAT- 2012/10/12 06:00
MHDA- 2013/11/13 06:00
CRDT- 2012/10/12 06:00
PHST- 2008/02/15 00:00 [received]
PHST- 2012/07/31 00:00 [accepted]
PHST- 2012/10/12 06:00 [entrez]
PHST- 2012/10/12 06:00 [pubmed]
PHST- 2013/11/13 06:00 [medline]
AID - 10.1007/s11948-012-9393-4 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2012 Sep;18(3):573-91. doi: 10.1007/s11948-012-9393-4. Epub 2012 
      Sep 29.


PMID- 23054670
OWN - NLM
STAT- MEDLINE
DCOM- 20131112
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 18
IP  - 3
DP  - 2012 Sep
TI  - Translating neuroethics: reflections from Muslim ethics: commentary on "Ethical
      concepts and future challenges of neuroimaging: an islamic perspective".
PG  - 519-28
LID - 10.1007/s11948-012-9392-5 [doi]
AB  - Muslim ethics is cautiously engaging developments in neuroscience. In their
      encounters with developments in neuroscience such as brain death and functional
      magnetic resonance imaging procedures, Muslim ethicists might be on the cusp of
      spirited debates. Science and religion perform different kinds of work and ought 
      not to be conflated. Cultural translation is central to negotiating the complex
      life worlds of religious communities, Muslims included. Cultural translation
      involves lived encounters with modernity and its byproduct, modern science.
      Serious ethical debate requires more than just a mere instrumental encounter with
      science. A robust Muslim approach to neuroethics might require an emulsion of
      religion and neuroscience, thought and body, and body and soul. Yet one must
      anticipate that Muslim debates in neuroethics will be inflected with Muslim
      values, symbols and the discrete faith perspectives of this tradition with
      meanings that are specific to people who share this worldview and their concerns.
FAU - Moosa, Ebrahim
AU  - Moosa E
AD  - Department of Religion, Duke University, Durham, NC, USA. emoosa@gmail.com
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20120929
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
CON - Sci Eng Ethics. 2012 Sep;18(3):509-18. PMID: 22865482
MH  - *Brain
MH  - *Culture
MH  - Humans
MH  - *Islam
MH  - *Morals
MH  - Neuroimaging/*ethics
MH  - Neurosciences/*ethics
MH  - *Spirituality
EDAT- 2012/10/12 06:00
MHDA- 2013/11/13 06:00
CRDT- 2012/10/12 06:00
PHST- 2012/05/03 00:00 [received]
PHST- 2012/07/31 00:00 [accepted]
PHST- 2012/10/12 06:00 [entrez]
PHST- 2012/10/12 06:00 [pubmed]
PHST- 2013/11/13 06:00 [medline]
AID - 10.1007/s11948-012-9392-5 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2012 Sep;18(3):519-28. doi: 10.1007/s11948-012-9392-5. Epub 2012 
      Sep 29.


PMID- 23054669
OWN - NLM
STAT- MEDLINE
DCOM- 20131112
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 18
IP  - 3
DP  - 2012 Sep
TI  - Neuroscience, ethics and legal responsibility: the problem of the insanity
      defense. Commentary on "The ethics of neuroscience and the neuroscience of
      ethics: a phenomenological-existential approach".
PG  - 475-81
LID - 10.1007/s11948-012-9390-7 [doi]
AB  - The insanity defense presents many difficult questions for the legal system. It
      attracts attention beyond its practical significance (it is seldom used
      successfully) because it goes to the heart of the concept of legal
      responsibility. "Not guilty by reason of insanity" generally requires that as a
      result of mental illness the defendant was unable to distinguish right from wrong
      at the time of the crime. The many difficult and complex questions presented by
      the insanity defense have led some in the legal community to hope that
      neuroscience might help resolve some of these problems, but that hope is not
      likely to be realized.
FAU - Smith, Steven R
AU  - Smith SR
AD  - California Western School of Law, 225 Cedar Street, San Diego, CA 92101, USA.
      srs@cwsl.edu
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20120929
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
CON - Sci Eng Ethics. 2012 Sep;18(3):457-74. PMID: 23054668
MH  - *Brain
MH  - Consciousness/*ethics
MH  - *Existentialism
MH  - *Morals
MH  - Neurosciences/*ethics
MH  - *Personal Autonomy
MH  - Psychophysiology/*ethics
EDAT- 2012/10/12 06:00
MHDA- 2013/11/13 06:00
CRDT- 2012/10/12 06:00
PHST- 2011/11/14 00:00 [received]
PHST- 2012/07/10 00:00 [accepted]
PHST- 2012/10/12 06:00 [entrez]
PHST- 2012/10/12 06:00 [pubmed]
PHST- 2013/11/13 06:00 [medline]
AID - 10.1007/s11948-012-9390-7 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2012 Sep;18(3):475-81. doi: 10.1007/s11948-012-9390-7. Epub 2012 
      Sep 29.


PMID- 23054668
OWN - NLM
STAT- MEDLINE
DCOM- 20131112
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 18
IP  - 3
DP  - 2012 Sep
TI  - The ethics of neuroscience and the neuroscience of ethics: a
      phenomenological-existential approach.
PG  - 457-74
LID - 10.1007/s11948-012-9388-1 [doi]
AB  - Advances in the neurosciences have many implications for a collective
      understanding of what it means to be human, in particular, notions of the self,
      the concept of volition or agency, questions of individual responsibility, and
      the phenomenology of consciousness. As the ability to peer directly into the
      brain is scientifically honed, and conscious states can be correlated with
      patterns of neural processing, an easy--but premature--leap is to postulate a
      one-way, brain-based determinism. That leap is problematic, however, and emerging
      findings in neuroscience can even be seen as compatible with some of the basic
      tenets of existentialism. Given the compelling authority of modern "science," it 
      is especially important to question how the findings of neuroscience are framed, 
      and how the articulation of research results challenge or change individuals'
      perceptions of themselves. Context plays an essential role in the emergence of
      human identity and in the sculpting of the human brain; for example, even a lack 
      of stimuli ("nothing") can lead to substantial consequences for brain, behavior, 
      and experience. Conversely, advances in understanding the brain might contribute 
      to more precise definitions of what it means to be human, including definitions
      of appropriate social and moral behavior. Put another way, the issue is not
      simply the ethics involved in framing neurotechnology, but also the incorporation
      of neuroscientific findings into a richer understanding of human ethical (and
      existential) functioning.
FAU - Frost, Christopher J
AU  - Frost CJ
AD  - Psychology and Religious Studies, St. Joseph's College, New York, 155 West Roe
      Boulevard, Patchogue, NY 11772, USA. cfrost@sjcny.edu
FAU - Lumia, Augustus R
AU  - Lumia AR
LA  - eng
PT  - Journal Article
DEP - 20120928
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
CIN - Sci Eng Ethics. 2012 Sep;18(3):475-81. PMID: 23054669
MH  - *Brain
MH  - Consciousness/*ethics
MH  - Ego
MH  - *Existentialism
MH  - *Morals
MH  - Neurosciences/*ethics
MH  - *Personal Autonomy
MH  - Psychophysiology/*ethics
MH  - Social Behavior
MH  - Technology/ethics
MH  - Volition
EDAT- 2012/10/12 06:00
MHDA- 2013/11/13 06:00
CRDT- 2012/10/12 06:00
PHST- 2008/03/28 00:00 [received]
PHST- 2012/07/09 00:00 [accepted]
PHST- 2012/10/12 06:00 [entrez]
PHST- 2012/10/12 06:00 [pubmed]
PHST- 2013/11/13 06:00 [medline]
AID - 10.1007/s11948-012-9388-1 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2012 Sep;18(3):457-74. doi: 10.1007/s11948-012-9388-1. Epub 2012 
      Sep 28.


PMID- 23054141
OWN - NLM
STAT- MEDLINE
DCOM- 20130822
LR  - 20211021
IS  - 2210-7711 (Electronic)
VI  - 35
IP  - 1
DP  - 2013 Feb
TI  - Geographic location of antineoplastic agent clinical trials conducted in
      developed and developing countries.
PG  - 87-91
LID - 10.1007/s11096-012-9711-6 [doi]
AB  - BACKGROUND: For the past 30 years, clinical trials have been increasingly
      conducted in developing countries. These trials allow results to be generalizable
      to similar populations, offer access to treatment for patients in need, and
      examine diseases with differing patterns than developed countries. However, the
      characteristics of antineoplastic clinical trials and recent trends in study
      location in developing countries are unknown. OBJECTIVE: The primary objective
      was to evaluate the location, study phase, results, funding source, and ethics
      board approval of randomized double-blind controlled clinical trials evaluating
      antineoplastic agents by geographic location. SETTING: This is a retrospective
      evaluation of studies indexed in the PubMed/Medline database published in
      2007-2011. METHODS: Clinical trials were identified with the search terms "drug
      therapy", "antineoplastic agents" and "double blind method" and limited to
      English language, human, and randomized controlled trial. MAIN OUTCOME MEASURE:
      We assessed frequencies of characteristics of antineoplastic clinical trials.
      RESULTS: A total of 116 trials evaluating antineoplastic drug therapy were
      identified. The highest frequency of clinical trials were published in 2009 (27.6
      %), followed by 2011 (23.3 %), 2010 (20.7 %), 2007 (14.6 %), and 2008 (13.8 %).
      According to geographic region, 33.8 % were conducted in North America, followed 
      by Europe (31.5 %) and Asia (16.2 %). Based on economic status, the majority
      (77.8 %) of clinical trial locations were in developed countries and 22.2 % were 
      in developing countries. No significant difference was found between study
      locations in developed countries and developing countries from 2007 to 2011. When
      comparing studies conducted in developing and developed countries, there was no
      difference in the year published, study phase, results, funding source, or
      investigational review board approval and informed consent. Studies conducted in 
      developed countries were significantly more likely to be single country studies
      (p = 0.02) and published in a journal with an impact factor greater than 10 (p = 
      0.013) when compared to studies conducted in developing countries. CONCLUSIONS:
      Based on economic status, there was no significant location change of
      antineoplastic clinical trials from 2007 to 2011. Clinical trials conducted in
      developing countries were more often multi-country studies and published in
      journals with lower impact factors.
FAU - Lu, Feng
AU  - Lu F
AD  - College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN
      38163, USA.
FAU - Suda, Katie J
AU  - Suda KJ
FAU - Marks, Katherine E
AU  - Marks KE
LA  - eng
PT  - Journal Article
DEP - 20121010
PL  - Netherlands
TA  - Int J Clin Pharm
JT  - International journal of clinical pharmacy
JID - 101554912
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Antineoplastic Agents/*therapeutic use
MH  - Developed Countries
MH  - Developing Countries
MH  - Double-Blind Method
MH  - Humans
MH  - Neoplasms/*drug therapy
MH  - *Randomized Controlled Trials as Topic
EDAT- 2012/10/12 06:00
MHDA- 2013/08/24 06:00
CRDT- 2012/10/12 06:00
PHST- 2012/05/11 00:00 [received]
PHST- 2012/09/29 00:00 [accepted]
PHST- 2012/10/12 06:00 [entrez]
PHST- 2012/10/12 06:00 [pubmed]
PHST- 2013/08/24 06:00 [medline]
AID - 10.1007/s11096-012-9711-6 [doi]
PST - ppublish
SO  - Int J Clin Pharm. 2013 Feb;35(1):87-91. doi: 10.1007/s11096-012-9711-6. Epub 2012
      Oct 10.


PMID- 23054053
OWN - NLM
STAT- MEDLINE
DCOM- 20121214
LR  - 20181023
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 345
DP  - 2012 Oct 10
TI  - Law, ethics, and the duty of care.
PG  - e6804
LID - 10.1136/bmj.e6804 [doi]
LID - bmj.e6804 [pii]
FAU - Sokol, Daniel K
AU  - Sokol DK
AD  - Imperial College London. daniel.sokol@talk21.com
LA  - eng
PT  - Journal Article
DEP - 20121010
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
SB  - IM
MH  - Bioethical Issues
MH  - Ethics, Medical
MH  - Homicide/legislation & jurisprudence
MH  - Humans
MH  - Malpractice/*legislation & jurisprudence
MH  - Moral Obligations
MH  - Standard of Care/ethics/*legislation & jurisprudence
MH  - United Kingdom
MH  - Vasectomy/legislation & jurisprudence
EDAT- 2012/10/12 06:00
MHDA- 2012/12/15 06:00
CRDT- 2012/10/12 06:00
PHST- 2012/10/12 06:00 [entrez]
PHST- 2012/10/12 06:00 [pubmed]
PHST- 2012/12/15 06:00 [medline]
AID - 10.1136/bmj.e6804 [doi]
PST - epublish
SO  - BMJ. 2012 Oct 10;345:e6804. doi: 10.1136/bmj.e6804.


PMID- 23053275
OWN - NLM
STAT- MEDLINE
DCOM- 20130509
LR  - 20121119
IS  - 0942-0940 (Electronic)
IS  - 0001-6268 (Linking)
VI  - 154
IP  - 12
DP  - 2012 Dec
TI  - Introducing a nationwide registry: the Swiss study on aneurysmal subarachnoid
      haemorrhage (Swiss SOS).
PG  - 2173-8; discussion 2178
LID - 10.1007/s00701-012-1500-4 [doi]
AB  - BACKGROUND: Aneurysmal subarachnoid haemorrhage (aSAH) is a haemorrhagic form of 
      stroke and occurs in a younger population compared with ischaemic stroke or
      intracerebral haemorrhage. It accounts for a large proportion of productive
      life-years lost to stroke. Its surgical and medical treatment represents a
      multidisciplinary effort. Due to the complexity of the disease, the management
      remains difficult to standardise and quality of care is accordingly difficult to 
      assess. OBJECTIVE: To create a registry to assess management parameters of
      patients treated for aSAH in Switzerland. METHODS: A cohort study was initiated
      with the aim to record characteristics of patients admitted with aSAH, starting
      January 1st 2009. Ethical committee approval was obtained or is pending from the 
      institutional review boards of all centres. In the study period, seven Swiss
      hospitals (five university [U], two non-university medical centres) harbouring a 
      neurosurgery department, an intensive care unit and an interventional
      neuroradiology team so far agreed to participate in the registry (Aarau, Basel
      [U], Bern [U], Geneva [U], Lausanne [U], St. Gallen, Zurich [U]). Demographic and
      clinical parameters are entered into a common database. DISCUSSION: This database
      will soon provide (1) a nationwide assessment of the current standard of care and
      (2) the outcomes for patients suffering from aSAH in Switzerland. Based on data
      from this registry, we can conduct cohort comparisons or design diagnostic or
      therapeutic studies on a national level. Moreover, a standardised registration
      system will allow healthcare providers to assess the quality of care.
FAU - Schatlo, Bawarjan
AU  - Schatlo B
AD  - Department of Neurosurgery, Geneva University Hospital, Switzerland.
FAU - Fung, Christian
AU  - Fung C
FAU - Fathi, Ali-Reza
AU  - Fathi AR
FAU - Sailer, Martin
AU  - Sailer M
FAU - Winkler, Kerstin
AU  - Winkler K
FAU - Daniel, Roy Thomas
AU  - Daniel RT
FAU - Bijlenga, Philippe
AU  - Bijlenga P
FAU - Ahlborn, Peter
AU  - Ahlborn P
FAU - Seule, Martin
AU  - Seule M
FAU - Zumofen, Daniel
AU  - Zumofen D
FAU - Reinert, Michael
AU  - Reinert M
FAU - Woernle, Christoph
AU  - Woernle C
FAU - Stienen, Martin
AU  - Stienen M
FAU - Levivier, Marc
AU  - Levivier M
FAU - Hildebrandt, Gerhard
AU  - Hildebrandt G
FAU - Mariani, Luigi
AU  - Mariani L
FAU - Bernays, Rene
AU  - Bernays R
FAU - Fandino, Javier
AU  - Fandino J
FAU - Raabe, Andreas
AU  - Raabe A
FAU - Keller, Emanuela
AU  - Keller E
FAU - Schaller, Karl
AU  - Schaller K
LA  - eng
PT  - Journal Article
DEP - 20121006
PL  - Austria
TA  - Acta Neurochir (Wien)
JT  - Acta neurochirurgica
JID - 0151000
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Ischemia/*prevention & control
MH  - Male
MH  - Middle Aged
MH  - Neurosurgical Procedures/*standards
MH  - *Registries
MH  - Subarachnoid Hemorrhage/*therapy
MH  - Switzerland
MH  - Young Adult
EDAT- 2012/10/12 06:00
MHDA- 2013/05/10 06:00
CRDT- 2012/10/12 06:00
PHST- 2012/05/18 00:00 [received]
PHST- 2012/09/13 00:00 [accepted]
PHST- 2012/10/12 06:00 [entrez]
PHST- 2012/10/12 06:00 [pubmed]
PHST- 2013/05/10 06:00 [medline]
AID - 10.1007/s00701-012-1500-4 [doi]
PST - ppublish
SO  - Acta Neurochir (Wien). 2012 Dec;154(12):2173-8; discussion 2178. doi:
      10.1007/s00701-012-1500-4. Epub 2012 Oct 6.


PMID- 23053250
OWN - NLM
STAT- MEDLINE
DCOM- 20140210
LR  - 20211021
IS  - 1435-604X (Electronic)
IS  - 0268-8921 (Linking)
VI  - 28
IP  - 4
DP  - 2013 Jul
TI  - Anti-inflammatory effect of low-intensity laser on the healing of third-degree
      burn wounds in rats.
PG  - 1169-76
LID - 10.1007/s10103-012-1213-1 [doi]
AB  - Third-degree burn wounds are considered severe injuries because they destroy all 
      the skin layers and may affect subcutaneous tissues, fasciae, muscles, and bones.
      To favor the healing process of the injured tissues, it is very useful to
      diminish the occurrence of the inflammatory process. The present study was aimed 
      at comparing the effect of different energetic densities of AlGaInP laser on the 
      inflammatory process and in the healing of third-degree burn wounds in Wistar
      rats. This study was approved by the Ethics Committee, in which 36 adult male
      rats were selected and suffered the induction of third-degree burn injury. These 
      rats were divided as follows: group 1-control (treated with silver sulfadiazine),
      group 2-received energy density of 3 J/cm(2), and group 3-received energy density
      of 6 J/cm(2). All animals daily received an occlusive bandage with silver
      sulfadiazine and 8 % papain. The laser therapy was performed alternatively three 
      times a week. The animals were evaluated on the 3rd, 7th, 14th, and 21st days
      after the initial lesion and euthanized for the macroscopic, histologic, and
      morphometric analysis. A higher production of collagen was observed at 7 days and
      a greater re-epithelialization at 21 days in group 3 (6 J/cm(2)). Furthermore,
      the latter when compared to the other groups presented macroscopically a better
      aspect of the scar at 21 days with more granulation tissue and fibrosis. We
      conclude that the AlGaInP laser used in dosages of 3 and 6 J/cm(2) favors the
      healing of third-degree burn wounds induced in rats.
FAU - de Moraes, Juliana Medeiros
AU  - de Moraes JM
AD  - Biological Sciences Institute, Federal University of Goias (UFG), Campus
      II-Samambaia, saida para Neropolis-Km 13, Goiania, GO, 74001-970, Brazil.
FAU - Eterno de Oliveira Mendonca, Diego
AU  - Eterno de Oliveira Mendonca D
FAU - Moura, Vania Beatriz L
AU  - Moura VB
FAU - Oliveira, Milton Adriano Pelli
AU  - Oliveira MA
FAU - Afonso, Cristina Lopes
AU  - Afonso CL
FAU - Vinaud, Marina Clare
AU  - Vinaud MC
FAU - Bachion, Maria Marcia
AU  - Bachion MM
FAU - de Souza Lino, Ruy Jr
AU  - de Souza Lino R Jr
LA  - eng
PT  - Journal Article
DEP - 20121009
PL  - England
TA  - Lasers Med Sci
JT  - Lasers in medical science
JID - 8611515
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Animals
MH  - Burns/metabolism/pathology/*radiotherapy
MH  - Collagen/biosynthesis
MH  - Inflammation/pathology/radiotherapy
MH  - Lasers, Semiconductor/therapeutic use
MH  - Low-Level Light Therapy/*methods
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Wound Healing/physiology/*radiation effects
EDAT- 2012/10/12 06:00
MHDA- 2014/02/11 06:00
CRDT- 2012/10/12 06:00
PHST- 2012/05/09 00:00 [received]
PHST- 2012/09/28 00:00 [accepted]
PHST- 2012/10/12 06:00 [entrez]
PHST- 2012/10/12 06:00 [pubmed]
PHST- 2014/02/11 06:00 [medline]
AID - 10.1007/s10103-012-1213-1 [doi]
PST - ppublish
SO  - Lasers Med Sci. 2013 Jul;28(4):1169-76. doi: 10.1007/s10103-012-1213-1. Epub 2012
      Oct 9.


PMID- 23052523
OWN - NLM
STAT- MEDLINE
DCOM- 20130802
LR  - 20211021
IS  - 1432-2218 (Electronic)
IS  - 0930-2794 (Linking)
VI  - 27
IP  - 3
DP  - 2013 Mar
TI  - Minimally invasive oesophagectomy versus open surgery: is there an advantage?
PG  - 724-31
LID - 10.1007/s00464-012-2546-3 [doi]
AB  - BACKGROUND: Oesophageal resection is the main method of curative treatment for
      cancer of the oesophagus. Despite advances in surgical technology and
      postoperative care, the survival rate and prognosis of people undergoing
      oesophagectomy is still poor. The use of minimally invasive techniques in
      oesophageal surgery offers hope of reduced recovery time due to a reduction in
      surgical trauma. Although the first reports of thoracoscopy- and
      laparoscopy-assisted oesophagectomy emerged some 20 years ago, there is still no 
      consensus that the outcomes are clearly superior to outcomes following
      conventional open surgery. Increasingly, some surgeons promote the use of
      minimally invasive techniques for oesophagectomy but questions remain over its
      safety and efficacy compared with open surgery. METHODS: We conducted a
      systematic review of the literature to compare minimally invasive techniques for 
      oesophagectomy to open surgery. The outcomes of interest for efficacy and safety 
      included mortality, operative complications, recurrence, and quality of life.
      RESULTS: There were 28 included comparative studies. No randomised controlled
      studies (RCTs) were available and therefore the data need to be interpreted with 
      caution. CONCLUSION: Recommendations for future research are discussed. We argue 
      that it is difficult to conduct an RCT for this procedure due to ethical
      considerations and suggest ways that future nonrandomised studies could be
      improved.
FAU - Uttley, Lesley
AU  - Uttley L
AD  - School of Health and Related Research, University of Sheffield, Regent Court, 30 
      Regent Street, Sheffield S1 4DA, UK. l.uttley@sheffield.ac.uk
FAU - Campbell, Fiona
AU  - Campbell F
FAU - Rhodes, Michael
AU  - Rhodes M
FAU - Cantrell, Anna
AU  - Cantrell A
FAU - Stegenga, Heather
AU  - Stegenga H
FAU - Lloyd-Jones, Myfanwy
AU  - Lloyd-Jones M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20121006
PL  - Germany
TA  - Surg Endosc
JT  - Surgical endoscopy
JID - 8806653
SB  - IM
CIN - Surg Endosc. 2013 Nov;27(11):4401-2. PMID: 23807755
CIN - Surg Endosc. 2013 Nov;27(11):4399-400. PMID: 23820867
MH  - Conversion to Open Surgery
MH  - Esophageal Neoplasms/*surgery
MH  - Esophagectomy/*methods
MH  - Esophagoscopy/*methods
MH  - Humans
MH  - Neoplasm Recurrence, Local/etiology
MH  - Postoperative Complications/etiology
MH  - Prospective Studies
MH  - Quality of Life
MH  - Retrospective Studies
EDAT- 2012/10/12 06:00
MHDA- 2013/08/03 06:00
CRDT- 2012/10/12 06:00
PHST- 2012/04/20 00:00 [received]
PHST- 2012/08/09 00:00 [accepted]
PHST- 2012/10/12 06:00 [entrez]
PHST- 2012/10/12 06:00 [pubmed]
PHST- 2013/08/03 06:00 [medline]
AID - 10.1007/s00464-012-2546-3 [doi]
PST - ppublish
SO  - Surg Endosc. 2013 Mar;27(3):724-31. doi: 10.1007/s00464-012-2546-3. Epub 2012 Oct
      6.


PMID- 23050522
OWN - NLM
STAT- MEDLINE
DCOM- 20130627
LR  - 20211203
IS  - 1557-8534 (Electronic)
IS  - 1547-3287 (Linking)
VI  - 22
IP  - 3
DP  - 2013 Feb 1
TI  - Human mid-trimester amniotic fluid stem cells cultured under embryonic stem cell 
      conditions with valproic acid acquire pluripotent characteristics.
PG  - 444-58
LID - 10.1089/scd.2012.0267 [doi]
AB  - Human mid-trimester amniotic fluid stem cells (AFSC) have promising applications 
      in regenerative medicine, being broadly multipotent with an intermediate
      phenotype between embryonic (ES) and mesenchymal stem cells (MSC). Despite this
      propluripotent phenotype, AFSC are usually cultured in adherence in a serum-based
      expansion medium, and how expansion in conditions sustaining pluripotency might
      affect their phenotype remains unknown. We recently showed that early AFSC from
      first trimester amniotic fluid, which endogenously express Sox2 and Klf4, can be 
      reprogrammed to pluripotency without viral vectors using the histone deacetylase 
      inhibitor valproic acid (VPA). Here, we show that mid-trimester AFSC cultured
      under MSC conditions contained a subset of cells endogenously expressing
      telomerase, CD24, OCT4, C-MYC, and SSEA4, but low/null levels of SOX2, NANOG,
      KLF4, SSEA3, TRA-1-60, and TRA-1-81, with cells unable to form embryoid bodies
      (EBs) or teratomas. In contrast, AFSC cultured under human ESC conditions were
      smaller in size, grew faster, formed colonies, upregulated OCT4 and C-MYC, and
      expressed KLF4 and SOX2, but not NANOG, SSEA3, TRA-1-60, and TRA-1-81.
      Supplementation with VPA for 5 days further upregulated OCT4, KLF4, and SOX2, and
      induced expression of NANOG, SSEA3, TRA-1-60, and TRA-1-81, with cells now able
      to form EBs and teratomas. We conclude that human mid-trimester AFSC, which may
      be isolated autologously during pregnancy without ethics restriction, can acquire
      pluripotent characteristics without the use of ectopic factors. Our data suggest 
      that this medium-dependant approach to pluripotent mid-trimester AFSC reflects
      true reprogramming and not the selection of prepluripotent cells.
FAU - Moschidou, Dafni
AU  - Moschidou D
AD  - The Institute of Reproductive and Developmental Biology, Imperial College London,
      London, UK.
FAU - Mukherjee, Sayandip
AU  - Mukherjee S
FAU - Blundell, Michael P
AU  - Blundell MP
FAU - Jones, Gemma N
AU  - Jones GN
FAU - Atala, Anthony J
AU  - Atala AJ
FAU - Thrasher, Adrian J
AU  - Thrasher AJ
FAU - Fisk, Nicholas M
AU  - Fisk NM
FAU - De Coppi, Paolo
AU  - De Coppi P
FAU - Guillot, Pascale V
AU  - Guillot PV
LA  - eng
GR  - 090233/Wellcome Trust/United Kingdom
PT  - Journal Article
DEP - 20121127
PL  - United States
TA  - Stem Cells Dev
JT  - Stem cells and development
JID - 101197107
RN  - 0 (Antigens, Differentiation)
RN  - 0 (Culture Media)
RN  - 0 (Histone Deacetylase Inhibitors)
RN  - 0 (KLF4 protein, human)
RN  - 0 (Klf4 protein, mouse)
RN  - 0 (Kruppel-Like Factor 4)
RN  - 0 (Kruppel-Like Transcription Factors)
RN  - 0 (MYC protein, human)
RN  - 0 (Octamer Transcription Factor-3)
RN  - 0 (POU5F1 protein, human)
RN  - 0 (Proto-Oncogene Proteins c-myc)
RN  - 0 (SOX2 protein, human)
RN  - 0 (SOXB1 Transcription Factors)
RN  - 614OI1Z5WI (Valproic Acid)
SB  - IM
MH  - Amniotic Fluid/*cytology
MH  - Animals
MH  - Antigens, Differentiation/genetics/*metabolism
MH  - Cell Proliferation
MH  - Cell Shape
MH  - Cells, Cultured
MH  - Culture Media
MH  - Embryonic Stem Cells/metabolism
MH  - Female
MH  - Gene Expression
MH  - Histone Deacetylase Inhibitors/*pharmacology
MH  - Humans
MH  - Kruppel-Like Factor 4
MH  - Kruppel-Like Transcription Factors/genetics/metabolism
MH  - Mesenchymal Stem Cells/metabolism
MH  - Mice
MH  - Neoplasms, Experimental/pathology
MH  - Octamer Transcription Factor-3/genetics/metabolism
MH  - Pluripotent Stem Cells/drug effects/*metabolism/physiology/transplantation
MH  - Pregnancy
MH  - Pregnancy Trimester, Second
MH  - Proto-Oncogene Proteins c-myc/genetics/metabolism
MH  - SOXB1 Transcription Factors/genetics/metabolism
MH  - Telomere/metabolism
MH  - Teratoma/pathology
MH  - Up-Regulation/drug effects
MH  - Valproic Acid/*pharmacology
EDAT- 2012/10/12 06:00
MHDA- 2013/06/29 06:00
CRDT- 2012/10/12 06:00
PHST- 2012/10/12 06:00 [entrez]
PHST- 2012/10/12 06:00 [pubmed]
PHST- 2013/06/29 06:00 [medline]
AID - 10.1089/scd.2012.0267 [doi]
PST - ppublish
SO  - Stem Cells Dev. 2013 Feb 1;22(3):444-58. doi: 10.1089/scd.2012.0267. Epub 2012
      Nov 27.


PMID- 23050137
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121011
LR  - 20211021
IS  - 2090-147X (Electronic)
IS  - 2090-1461 (Linking)
VI  - 2012
DP  - 2012
TI  - Excised abdominoplasty material as a systematic plastic surgical training model.
PG  - 834212
LID - 10.1155/2012/834212 [doi]
AB  - Achieving a level of technical skill and confidence in surgical operations is the
      main goal of plastic surgical training. Operating rooms were accepted as the
      practical teaching venues of the traditional apprenticeship model. However,
      increased patient population, time, and ethical and legal considerations made
      preoperation room practical work a must for plastic surgical training. There are 
      several plastic surgical teaching models and simulators which are very useful in 
      preoperation room practical training and the evaluation of plastic surgery
      residents. The full thickness skin with its vascular network excised in
      abdominoplasty procedures is an easily obtainable real human tissue which could
      be used as a training model in plastic surgery.
FAU - Demirseren, M Erol
AU  - Demirseren ME
AD  - Department of Plastic, Reconstructive and Aesthetic Surgery, Ataturk Training and
      Research Hospital, 06810 Ankara, Turkey.
FAU - Ceran, Candemir
AU  - Ceran C
FAU - Duman, Yakup
AU  - Duman Y
FAU - Sarici, Murat
AU  - Sarici M
LA  - eng
PT  - Journal Article
DEP - 20120926
PL  - United States
TA  - Plast Surg Int
JT  - Plastic surgery international
JID - 101578808
PMC - PMC3463908
EDAT- 2012/10/11 06:00
MHDA- 2012/10/11 06:01
CRDT- 2012/10/11 06:00
PHST- 2012/05/31 00:00 [received]
PHST- 2012/07/19 00:00 [revised]
PHST- 2012/08/27 00:00 [accepted]
PHST- 2012/10/11 06:00 [entrez]
PHST- 2012/10/11 06:00 [pubmed]
PHST- 2012/10/11 06:01 [medline]
AID - 10.1155/2012/834212 [doi]
PST - ppublish
SO  - Plast Surg Int. 2012;2012:834212. doi: 10.1155/2012/834212. Epub 2012 Sep 26.


PMID- 23049854
OWN - NLM
STAT- MEDLINE
DCOM- 20130507
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 9
DP  - 2012
TI  - The preventive and therapeutic effects of intravenous human adipose-derived stem 
      cells in Alzheimer's disease mice.
PG  - e45757
LID - 10.1371/journal.pone.0045757 [doi]
AB  - Alzheimer's disease (AD) is characterized by the accumulation of amyloid plaques 
      and neurofibrillary tangles accompanied by cognitive dysfunction. The aim of the 
      present study was to elucidate preventive and therapeutic potential of stem cells
      for AD. Among stem cells, autologous human adipose-derived stem cells (hASCs)
      elicit no immune rejection responses, tumorigenesis, or ethical problems. We
      found that intravenously transplanted hASCs passed through the BBB and migrated
      into the brain. The learning, memory and pathology in an AD mouse model (Tg2576) 
      mice greatly improved for at least 4 months after intravenous injection of hASC. 
      The number of amyloid plaques and Abeta levels decreased significantly in the
      brains of hASC-injected Tg mice compared to those of Tg-sham mice. Here, we first
      report that intravenously or intracerebrally transplanted hASCs significantly
      rescues memory deficit and neuropathology, in the brains of Tg mice by
      up-regulating IL-10 and VEGF and be a possible use for the prevention and
      treatment of AD.
FAU - Kim, Saeromi
AU  - Kim S
AD  - Department of Pharmacology, College of Medicine, Neuroscience Research Institute,
      MRC, Seoul National University, Seoul, South Korea.
FAU - Chang, Keun-A
AU  - Chang KA
FAU - Kim, Jeong a
AU  - Kim Ja
FAU - Park, Hyeong-Geun
AU  - Park HG
FAU - Ra, Jeong Chan
AU  - Ra JC
FAU - Kim, Hye-Sun
AU  - Kim HS
FAU - Suh, Yoo-Hun
AU  - Suh YH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120926
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Amyloidogenic Proteins)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Adipose Tissue/*cytology
MH  - Alzheimer Disease/*metabolism
MH  - Amyloidogenic Proteins/metabolism
MH  - Animals
MH  - Brain/metabolism
MH  - Cell- and Tissue-Based Therapy/*methods
MH  - Disease Models, Animal
MH  - Female
MH  - *Gene Expression Regulation
MH  - Humans
MH  - Injections, Intravenous
MH  - Interleukin-10/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Microscopy, Fluorescence/methods
MH  - Time Factors
MH  - Up-Regulation
MH  - Vascular Endothelial Growth Factor A/metabolism
PMC - PMC3458942
EDAT- 2012/10/11 06:00
MHDA- 2013/05/08 06:00
CRDT- 2012/10/11 06:00
PHST- 2012/04/30 00:00 [received]
PHST- 2012/08/23 00:00 [accepted]
PHST- 2012/10/11 06:00 [entrez]
PHST- 2012/10/11 06:00 [pubmed]
PHST- 2013/05/08 06:00 [medline]
AID - 10.1371/journal.pone.0045757 [doi]
AID - PONE-D-12-13439 [pii]
PST - ppublish
SO  - PLoS One. 2012;7(9):e45757. doi: 10.1371/journal.pone.0045757. Epub 2012 Sep 26.


PMID- 23049453
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121011
LR  - 20211021
IS  - 1524-5012 (Print)
IS  - 1524-5012 (Linking)
VI  - 12
IP  - 3
DP  - 2012 Fall
TI  - Bioethics in practice: a quarterly column about medical ethics - can children
      participate in research?
PG  - 188-90
FAU - White, Michael
AU  - White M
AD  - Department of Pediatric Cardiology, Ochsner Clinic Foundation, New Orleans, LA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ochsner J
JT  - The Ochsner journal
JID - 101125795
PMC - PMC3448238
EDAT- 2012/10/11 06:00
MHDA- 2012/10/11 06:01
CRDT- 2012/10/11 06:00
PHST- 2012/10/11 06:00 [entrez]
PHST- 2012/10/11 06:00 [pubmed]
PHST- 2012/10/11 06:01 [medline]
PST - ppublish
SO  - Ochsner J. 2012 Fall;12(3):188-90.


PMID- 23049175
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121011
LR  - 20211021
IS  - 0976-9382 (Electronic)
IS  - 0974-8520 (Linking)
VI  - 33
IP  - 1
DP  - 2012 Jan
TI  - Ethical prescription writing in Ayurveda.
PG  - 3-4
LID - 10.4103/0974-8520.100290 [doi]
FAU - Baghel, M S
AU  - Baghel MS
AD  - Director and Chief Editor - AYU, IPGT and RA, Gujarat Ayurved University,
      Jamnagar, Gujarat, India E-mail: directoripgt@ayurveduniversity.com.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Ayu
JT  - Ayu
JID - 7605807
PMC - PMC3456859
EDAT- 2012/10/11 06:00
MHDA- 2012/10/11 06:01
CRDT- 2012/10/11 06:00
PHST- 2012/10/11 06:00 [entrez]
PHST- 2012/10/11 06:00 [pubmed]
PHST- 2012/10/11 06:01 [medline]
AID - 10.4103/0974-8520.100290 [doi]
AID - Ayu-33-3 [pii]
PST - ppublish
SO  - Ayu. 2012 Jan;33(1):3-4. doi: 10.4103/0974-8520.100290.


PMID- 23049077
OWN - NLM
STAT- MEDLINE
DCOM- 20130725
LR  - 20191210
IS  - 1460-2350 (Electronic)
IS  - 0268-1161 (Linking)
VI  - 28
IP  - 2
DP  - 2013 Feb
TI  - Telomeric repeat-containing RNA and telomerase in human fetal oocytes.
PG  - 414-22
LID - 10.1093/humrep/des363 [doi]
AB  - STUDY QUESTION: What is the distribution of telomeric repeat-containing RNA
      (TERRA) and of telomerase in human fetal oocytes? SUMMARY ANSWER: TERRA forms
      discrete foci at telomeres of human fetal oocytes and it co-localizes with both
      the shelterin component telomeric repeat-binding factor 2 (TRF2) and the
      catalytic subunit of human telomerase at the telomeres of meiotic chromosomes.
      WHAT IS KNOWN ALREADY: TERRA is a structural element of the telomeric chromatin
      that has been described in somatic cells of many different eukaryote species. The
      telomerase enzyme is inactive in adult somatic cells but is active in germ cells,
      stem cells and in the majority of tumors; however, its distribution in oocytes is
      still unknown. STUDY DESIGN, SIZE, DURATION: For this study, ovarian samples from
      four euploid fetuses of 22 gestational weeks were used. These samples were
      obtained with the consent of the parents and of the Ethics Committee of Hospital 
      de la Vall d'Hebron. PARTICIPANTS/MATERIALS, SETTING, METHODS: We analyzed the
      distribution of TERRA and telomerase in cells derived from human fetal ovaries.
      The co-localization of TERRA, telomerase and telomeres was performed by
      optimizing a combination of immunofluorescence (IF) and RNA-fluorescent in situ
      hybridization (RNA-FISH) techniques. The synaptonemal complex protein 3 (SYCP3), 
      TRF2 and protein component of telomerase [telomerase reverse transcriptase
      (TERT)] were detected by IF, whereas TERRA was revealed by RNA-FISH using a
      (CCCTAA)(3) oligonucleotide. SYCP3 signals allowed us to identify oocytes that
      had entered meiosis and classify them into the different stages of prophase I,
      whereas TRF2 indicated the telomeric regions of chromosomes. MAIN RESULTS AND THE
      ROLE OF CHANCE: We show for the first time the presence of TERRA and the
      intracellular distribution of telomerase in human fetal ovarian cells. TERRA is
      present, forming discrete foci, in 75% of the ovarian tissue cells and most of
      TERRA molecules ( approximately 83%) are at telomeres (TRF2 co-localization).
      TERRA levels are higher in oocytes than in ovarian tissue cells (P = 0.00), and
      do not change along the progression of the prophase I stage (P = 0.37). TERRA is 
      present on approximately 23% of the telomeres in all cell types derived from
      human fetal ovaries. Moreover, approximately 22% of TERRA foci co-localize with
      the protein component of telomerase (TERT). LIMITATIONS, REASONS FOR CAUTION: We 
      present a descriptive/qualitative study of TERRA in human fetal ovarian tissue.
      Given the difficult access and manipulation of fetal samples, the number of fetal
      ovaries used in this study was limited. WIDER IMPLICATIONS OF THE FINDINGS: This 
      is the first report on TERRA expression in oocytes from human fetal ovaries. The 
      presence of TERRA at the telomeres of oocytes from the leptotene to pachytene
      stages and its co-localization with the telomerase protein component suggests
      that this RNA might participate in the maintenance of the telomere structure, at 
      least through the processes that take place during the female meiotic prophase I.
      Since telomeres in oocytes have been mainly studied regarding the bouquet
      structure, our results introduce a new viewpoint of the telomeric structure
      during meiosis.
FAU - Reig-Viader, Rita
AU  - Reig-Viader R
AD  - Departament de Biologia Cel.lular, Fisiologia i Immunologia, Universitat Autonoma
      de Barcelona, Campus UAB, Cerdanyola del Valles 08193, Spain.
FAU - Brieno-Enriquez, Miguel Angel
AU  - Brieno-Enriquez MA
FAU - Khoriauli, Lela
AU  - Khoriauli L
FAU - Toran, Nuria
AU  - Toran N
FAU - Cabero, Lluis
AU  - Cabero L
FAU - Giulotto, Elena
AU  - Giulotto E
FAU - Garcia-Caldes, Montserrat
AU  - Garcia-Caldes M
FAU - Ruiz-Herrera, Aurora
AU  - Ruiz-Herrera A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20121009
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
RN  - 63231-63-0 (RNA)
RN  - EC 2.7.7.49 (Telomerase)
SB  - IM
MH  - Cells, Cultured
MH  - Female
MH  - Fetus/*cytology/enzymology
MH  - HeLa Cells
MH  - Humans
MH  - Oocytes/*enzymology
MH  - RNA/*metabolism
MH  - Telomerase/*metabolism
EDAT- 2012/10/11 06:00
MHDA- 2013/07/26 06:00
CRDT- 2012/10/11 06:00
PHST- 2012/10/11 06:00 [entrez]
PHST- 2012/10/11 06:00 [pubmed]
PHST- 2013/07/26 06:00 [medline]
AID - des363 [pii]
AID - 10.1093/humrep/des363 [doi]
PST - ppublish
SO  - Hum Reprod. 2013 Feb;28(2):414-22. doi: 10.1093/humrep/des363. Epub 2012 Oct 9.


PMID- 23048103
OWN - NLM
STAT- MEDLINE
DCOM- 20130314
LR  - 20121010
IS  - 1544-5208 (Electronic)
IS  - 0278-2715 (Linking)
VI  - 31
IP  - 10
DP  - 2012 Oct
TI  - Enhancing patient autonomy through peer review to replace the FDA's rigorous
      approval process.
PG  - 2236-40
LID - 10.1377/hlthaff.2012.0793 [doi]
AB  - There may once have been a time when doctors unquestioningly accepted the
      government's declaration of a drug's effectiveness and when patients
      unquestioningly accepted the prescriptions of their doctors. That time has
      passed. Now, information--good and bad--showers from all directions on patients
      and physicians alike. A filter is needed, and peer review provides the best one. 
      But who or what is this validated information for? Ethically, its primary purpose
      is to enable patients to make decisions consistent with their values. Providing
      vetted information in a form that is useful to patients requires an emphasis on
      comprehensible, comprehensive, trustworthy, verifiable, and transparent
      communication. The hypothetical comparative effectiveness case study in this
      month's Health Affairs does not appear to rise to the level that would be helpful
      to providers or patients.
FAU - Caplan, Arthur
AU  - Caplan A
AD  - Division of Bioethics, New York University Langone Medical Center, New York, NY, 
      USA. Arthur.Caplan@nyumc.org
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Health Aff (Millwood)
JT  - Health affairs (Project Hope)
JID - 8303128
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - *Drug Approval
MH  - Humans
MH  - *Peer Review, Research
MH  - *Personal Autonomy
MH  - Pharmaceutical Preparations
MH  - United States
MH  - *United States Food and Drug Administration
EDAT- 2012/10/11 06:00
MHDA- 2013/03/15 06:00
CRDT- 2012/10/11 06:00
PHST- 2012/10/11 06:00 [entrez]
PHST- 2012/10/11 06:00 [pubmed]
PHST- 2013/03/15 06:00 [medline]
AID - 31/10/2236 [pii]
AID - 10.1377/hlthaff.2012.0793 [doi]
PST - ppublish
SO  - Health Aff (Millwood). 2012 Oct;31(10):2236-40. doi: 10.1377/hlthaff.2012.0793.


PMID- 23048080
OWN - NLM
STAT- MEDLINE
DCOM- 20130116
LR  - 20211021
IS  - 1488-2329 (Electronic)
IS  - 0820-3946 (Linking)
VI  - 184
IP  - 16
DP  - 2012 Nov 6
TI  - The ethics of elective ventilation.
PG  - E841-2
LID - 10.1503/cmaj.109-4261 [doi]
FAU - Monette, Michael
AU  - Monette M
LA  - eng
PT  - News
DEP - 20121009
PL  - Canada
TA  - CMAJ
JT  - CMAJ : Canadian Medical Association journal = journal de l'Association medicale
      canadienne
JID - 9711805
SB  - IM
MH  - Attitude of Health Personnel
MH  - Brain Death
MH  - Canada
MH  - Elective Surgical Procedures/*ethics
MH  - High-Frequency Ventilation/*ethics/methods
MH  - Humans
MH  - Informed Consent/ethics
MH  - Life Support Care/ethics
MH  - Living Donors/*ethics/statistics & numerical data
MH  - Needs Assessment
MH  - Organ Preservation/ethics/methods
MH  - Tissue and Organ Procurement/*ethics/methods
PMC - PMC3494331
EDAT- 2012/10/11 06:00
MHDA- 2013/01/17 06:00
CRDT- 2012/10/11 06:00
PHST- 2012/10/11 06:00 [entrez]
PHST- 2012/10/11 06:00 [pubmed]
PHST- 2013/01/17 06:00 [medline]
AID - cmaj.109-4261 [pii]
AID - 10.1503/cmaj.109-4261 [doi]
PST - ppublish
SO  - CMAJ. 2012 Nov 6;184(16):E841-2. doi: 10.1503/cmaj.109-4261. Epub 2012 Oct 9.


PMID- 23047839
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20220311
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 266
IP  - 1
DP  - 2013 Jan
TI  - Brain dysfunction primarily related to previous overt hepatic encephalopathy
      compared with minimal hepatic encephalopathy: resting-state functional MR imaging
      demonstration.
PG  - 261-70
LID - 10.1148/radiol.12120026 [doi]
AB  - PURPOSE: To investigate whether resting-state brain functional connectivity (FC) 
      differed among cirrhotic patients without overt hepatic encephalopathy (HE)
      (OHE), those who currently had minimal HE (MHE), or those who had recovered from 
      previous OHE and to investigate whether previous bouts of OHE rather than current
      MHE predominantly contributed to brain dysfunction in patients without current
      OHE. MATERIALS AND METHODS: This study was approved by the institutional ethics
      committee, and informed consent was obtained. Resting-state functional magnetic
      resonance (MR) data were compared between healthy controls and the following
      groups of cirrhotic patients: (a) patients without MHE and without previous OHE, 
      (b) patients with current MHE and without previous OHE, and (c) patients with
      previous OHE. Independent component analysis was applied to identify the best-fit
      component for the default-mode network (DMN). One-way analysis of variance was
      performed to detect different FC among groups. Pearson correlation analyses were 
      conducted to determine the relationships between FC and neurocognitive
      performance. RESULTS: Two important regions within the DMN, including the
      precuneus and posterior cingulate cortex and left medial frontal gyrus, showed
      significantly different FC among the four groups. A trend of gradually reduced FC
      in two regions was observed from controls, to patients without HE, and to
      patients with current MHE, while patients with previous OHE showed remarkably
      reduced FC in these two regions. Significant correlations were found between FC
      and neurocognitive performance in cirrhotic patients. CONCLUSION: The reduced
      resting-state FC within DMN was associated with neurocognitive impairments in MHE
      and after clinical resolution of OHE. Previous OHE rather than current MHE might 
      be primarily related to brain dysfunction in patients with latent OHE.
      SUPPLEMENTAL MATERIAL:
      http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.12120026/-/DC1.
CI  - RSNA, 2012
FAU - Chen, Hua-Jun
AU  - Chen HJ
AD  - Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of
      Radiology, Zhongda Hospital, Medical School of Southeast University, 87
      Dingjiaqiao Rd, Nanjing 210009, China.
FAU - Jiao, Yun
AU  - Jiao Y
FAU - Zhu, Xi-Qi
AU  - Zhu XQ
FAU - Zhang, Hong-Ying
AU  - Zhang HY
FAU - Liu, Jia-Cheng
AU  - Liu JC
FAU - Wen, Song
AU  - Wen S
FAU - Teng, Gao-Jun
AU  - Teng GJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121009
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
CIN - Radiology. 2013 Nov;269(2):622-3. PMID: 24155289
CIN - Radiology. 2013 Nov;269(2):623. PMID: 24312938
MH  - Brain/pathology/*physiopathology
MH  - Brain Mapping/*methods
MH  - Cognition Disorders/diagnosis/*etiology/*physiopathology
MH  - Female
MH  - Hepatic Encephalopathy/*complications/diagnosis/*physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
EDAT- 2012/10/11 06:00
MHDA- 2013/02/13 06:00
CRDT- 2012/10/11 06:00
PHST- 2012/10/11 06:00 [entrez]
PHST- 2012/10/11 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
AID - radiol.12120026 [pii]
AID - 10.1148/radiol.12120026 [doi]
PST - ppublish
SO  - Radiology. 2013 Jan;266(1):261-70. doi: 10.1148/radiol.12120026. Epub 2012 Oct 9.


PMID- 23047836
OWN - NLM
STAT- MEDLINE
DCOM- 20130227
LR  - 20220316
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 12
DP  - 2012 Dec
TI  - Ethical concerns for maternal surrogacy and reproductive tourism.
PG  - 742-5
LID - 10.1136/medethics-2012-100551 [doi]
AB  - Reproductive medical tourism is by some accounts a multibillion dollar industry
      globally. The seeking by clients in high income nations of surrogate mothers in
      low income nations, particularly India, presents a set of largely unexamined
      ethical challenges. In this paper, eight such challenges are elucidated to spur
      discussion and eventual policy development towards protecting the rights and
      health of vulnerable women of the Global South.
FAU - Deonandan, Raywat
AU  - Deonandan R
AD  - Interdisciplinary School of Health Sciences, University of Ottawa, Thompson
      HallTHN-039, 35 University Pvt, Ottawa, Ontario, Canada. ray@deonandan.com
FAU - Green, Samantha
AU  - Green S
FAU - van Beinum, Amanda
AU  - van Beinum A
LA  - eng
PT  - Journal Article
DEP - 20121009
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Adult
MH  - Child
MH  - Child Custody/ethics/legislation & jurisprudence
MH  - Child, Preschool
MH  - Commerce/*ethics
MH  - Delivery of Health Care/ethics/standards
MH  - Developed Countries
MH  - *Developing Countries
MH  - Embryo Transfer/ethics/methods
MH  - Female
MH  - Humans
MH  - India
MH  - Infant
MH  - Infant, Newborn
MH  - Informed Consent/ethics
MH  - Maternal Welfare/ethics
MH  - Medical Tourism/*ethics/trends
MH  - Patient Advocacy
MH  - *Poverty
MH  - Pregnancy
MH  - *Surrogate Mothers
MH  - *Vulnerable Populations
EDAT- 2012/10/11 06:00
MHDA- 2013/02/28 06:00
CRDT- 2012/10/11 06:00
PHST- 2012/10/11 06:00 [entrez]
PHST- 2012/10/11 06:00 [pubmed]
PHST- 2013/02/28 06:00 [medline]
AID - medethics-2012-100551 [pii]
AID - 10.1136/medethics-2012-100551 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Dec;38(12):742-5. doi: 10.1136/medethics-2012-100551. Epub
      2012 Oct 9.


PMID- 23047778
OWN - NLM
STAT- MEDLINE
DCOM- 20130107
LR  - 20121010
IS  - 1537-1948 (Electronic)
IS  - 0025-7079 (Linking)
VI  - 50
IP  - 11
DP  - 2012 Nov
TI  - The ethics of drug development and promotion: the need for a wider view.
PG  - 910-2
LID - 10.1097/MLR.0b013e31826c8767 [doi]
AB  - Ethical issues at the interface between the medical profession and the
      pharmaceutical industry have generally been approached from the vantage point of 
      medical professionalism, with a focus on conflict of interest as the key ethical 
      concern. Although conflicts of interest remain important, other ethical issues
      may be obscured unless a wider perspective is adopted. Besides medical
      professionalism, the ethics of the clinical therapeutic relationship, ethics of
      public health, and business ethics all provide additional insights.
FAU - Brody, Howard
AU  - Brody H
AD  - Institute for the Medical Humanities, University of Texas Medical Branch, 301
      University Boulevard, Galveston, TX 77555-1311, USA. habrody@utmb.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Care
JT  - Medical care
JID - 0230027
SB  - IM
MH  - Conflict of Interest
MH  - Drug Discovery/*ethics/*organization & administration
MH  - Drug Industry/*ethics/*organization & administration
MH  - Humans
MH  - Marketing/*ethics
MH  - Physician's Role
MH  - Physician-Patient Relations
MH  - Public Health/ethics
EDAT- 2012/10/11 06:00
MHDA- 2013/01/08 06:00
CRDT- 2012/10/11 06:00
PHST- 2012/10/11 06:00 [entrez]
PHST- 2012/10/11 06:00 [pubmed]
PHST- 2013/01/08 06:00 [medline]
AID - 10.1097/MLR.0b013e31826c8767 [doi]
AID - 00005650-201211000-00002 [pii]
PST - ppublish
SO  - Med Care. 2012 Nov;50(11):910-2. doi: 10.1097/MLR.0b013e31826c8767.


PMID- 23047777
OWN - NLM
STAT- MEDLINE
DCOM- 20130107
LR  - 20121010
IS  - 1537-1948 (Electronic)
IS  - 0025-7079 (Linking)
VI  - 50
IP  - 11
DP  - 2012 Nov
TI  - Pharmaceuticals and the health of the public: use, safety, cost, access, ethics, 
      and quality.
PG  - 907-9
LID - 10.1097/MLR.0b013e3182733b57 [doi]
FAU - Zito, Julie M
AU  - Zito JM
LA  - eng
PT  - Editorial
PT  - Introductory Journal Article
PL  - United States
TA  - Med Care
JT  - Medical care
JID - 0230027
RN  - 0 (Prescription Drugs)
SB  - IM
MH  - Drug Industry/*economics/ethics/*legislation & jurisprudence
MH  - Humans
MH  - Prescription Drugs/*adverse effects/*economics
MH  - *Public Health
MH  - Quality Control
MH  - United States
MH  - United States Food and Drug Administration/organization & administration
EDAT- 2012/10/11 06:00
MHDA- 2013/01/08 06:00
CRDT- 2012/10/11 06:00
PHST- 2012/10/11 06:00 [entrez]
PHST- 2012/10/11 06:00 [pubmed]
PHST- 2013/01/08 06:00 [medline]
AID - 10.1097/MLR.0b013e3182733b57 [doi]
AID - 00005650-201211000-00001 [pii]
PST - ppublish
SO  - Med Care. 2012 Nov;50(11):907-9. doi: 10.1097/MLR.0b013e3182733b57.


PMID- 23047749
OWN - NLM
STAT- MEDLINE
DCOM- 20130116
LR  - 20211021
IS  - 2150-7511 (Electronic)
VI  - 3
IP  - 5
DP  - 2012 Oct 9
TI  - The lessons of Asilomar and the H5N1 "affair".
LID - 10.1128/mBio.00354-12 [doi]
LID - e00354-12 [pii]
AB  - In mid-1974, soon after the first recombinant DNA molecules were replicated in
      Escherichia coli, scientists called for, and observed, a voluntary moratorium on 
      certain experiments. One goal of the moratorium was to hold a conference
      (Asilomar) to evaluate the risks, if any, of this new technology. The Asilomar
      conference concluded that recombinant DNA research should proceed but under
      strict guidelines. The furor surrounding the recent genetic manipulation of the
      transmissibility of avian influenza virus H5N1 led to a short-term moratorium
      that has been extended indefinitely. The question is how long should the
      moratorium remain in place, or should it be permanent? Voltaire observed,
      "History never repeats itself; man always does." I believe the parallels of
      Asilomar can be applied to the problem facing biomedical science today. We should
      move forward to establish standardized guidelines, using common sense and
      scientific creativity. The onus of responsibility falls on the individual
      scientist and involves the education of a new generation of scientists into the
      social and ethical implications of genetic engineering in a new age of genomics
      and synthetic biology. In addition, scientists who work with infectious agents
      must deal not only with biosafety but also, alas, with bioterrorism. The H5N1
      "affair" is not a question of freedom of inquiry or the dissemination of
      scientific research; it is a question of the social responsibility of science and
      scientists to ensure that the public understands why this work is beneficial and 
      worthwhile.
FAU - Falkow, Stanley
AU  - Falkow S
AD  - Department of Microbiology and Immunology, Stanford, California, USA.
LA  - eng
PT  - Journal Article
DEP - 20121009
PL  - United States
TA  - mBio
JT  - mBio
JID - 101519231
SB  - IM
MH  - Animals
MH  - Biomedical Research/ethics/legislation & jurisprudence/*methods
MH  - Birds
MH  - Containment of Biohazards/*methods
MH  - Genetic Engineering/ethics/legislation & jurisprudence/*methods
MH  - Guidelines as Topic
MH  - Humans
MH  - Influenza A Virus, H5N1 Subtype/genetics/*pathogenicity
MH  - Influenza in Birds/transmission/*virology
MH  - Influenza, Human/transmission/*virology
MH  - Mammals
MH  - Molecular Biology/ethics/legislation & jurisprudence/*methods
PMC - PMC3484388
EDAT- 2012/10/11 06:00
MHDA- 2013/01/17 06:00
CRDT- 2012/10/11 06:00
PHST- 2012/10/11 06:00 [entrez]
PHST- 2012/10/11 06:00 [pubmed]
PHST- 2013/01/17 06:00 [medline]
AID - mBio.00354-12 [pii]
AID - 10.1128/mBio.00354-12 [doi]
PST - epublish
SO  - mBio. 2012 Oct 9;3(5). pii: mBio.00354-12. doi: 10.1128/mBio.00354-12.


PMID- 23046881
OWN - NLM
STAT- MEDLINE
DCOM- 20131118
LR  - 20160518
IS  - 1876-1631 (Electronic)
IS  - 1876-1623 (Linking)
VI  - 89
DP  - 2012
TI  - Next generation sequencing in the clinical domain: clinical advantages,
      practical, and ethical challenges.
PG  - 27-63
LID - 10.1016/B978-0-12-394287-6.00002-1 [doi]
LID - B978-0-12-394287-6.00002-1 [pii]
AB  - There has been an academic "gold rush" with researchers mining the deep seams of 
      whole-exome and whole-genome sequencing since 2008. Although undoubtedly a major 
      advance initially for identifying new disease-associated genes for rare
      monogenetic disorders--more recently, common and complex conditions have been
      successfully studied using these techniques. With great power comes great
      responsibility, however, and we must not forget that next generation sequencing
      produces unique ethical conundrums and validation challenges. We review the
      progression of published papers using whole-exome sequencing from a clinical and 
      technical viewpoint before then reflecting on the key arguments that need to be
      fully understood before these tools can become a routine part of clinical
      practice and we ask what may be the role for the biomedical scientists?
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Thompson, Rose
AU  - Thompson R
AD  - Welsh Centre for Learning Disabilities, Cardiff University, Cardiff, UK.
FAU - Drew, Cheney J G
AU  - Drew CJ
FAU - Thomas, Rhys H
AU  - Thomas RH
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Adv Protein Chem Struct Biol
JT  - Advances in protein chemistry and structural biology
JID - 101497281
SB  - IM
MH  - Animals
MH  - Epilepsy/genetics
MH  - Exome/genetics
MH  - Genetic Counseling
MH  - High-Throughput Nucleotide Sequencing/methods/trends
MH  - Humans
MH  - Sequence Analysis, DNA/*methods/*trends
EDAT- 2012/10/11 06:00
MHDA- 2013/11/19 06:00
CRDT- 2012/10/11 06:00
PHST- 2012/10/11 06:00 [entrez]
PHST- 2012/10/11 06:00 [pubmed]
PHST- 2013/11/19 06:00 [medline]
AID - B978-0-12-394287-6.00002-1 [pii]
AID - 10.1016/B978-0-12-394287-6.00002-1 [doi]
PST - ppublish
SO  - Adv Protein Chem Struct Biol. 2012;89:27-63. doi:
      10.1016/B978-0-12-394287-6.00002-1.


PMID- 23046769
OWN - NLM
STAT- MEDLINE
DCOM- 20130321
LR  - 20181202
IS  - 1878-1888 (Electronic)
IS  - 0005-7894 (Linking)
VI  - 43
IP  - 4
DP  - 2012 Dec
TI  - Guidelines for cognitive behavioral training within doctoral psychology programs 
      in the United States: report of the Inter-organizational Task Force on Cognitive 
      and Behavioral Psychology Doctoral Education.
PG  - 687-97
LID - 10.1016/j.beth.2012.05.002 [doi]
LID - S0005-7894(12)00064-0 [pii]
AB  - The Association for Behavioral and Cognitive Therapies initiated an
      interorganizational task force to develop guidelines for integrated education and
      training in cognitive and behavioral psychology at the doctoral level in the
      United States. Fifteen task force members representing 16 professional
      associations participated in a year-long series of conferences, and developed a
      consensus on optimal doctoral education and training in cognitive and behavioral 
      psychology. The recommendations assume solid foundational training that is
      typical within applied psychology areas such as clinical and counseling
      psychology programs located in the United States. This article details the
      background, assumptions, and resulting recommendations specific to doctoral
      education and training in cognitive and behavioral psychology, including
      competencies expected in the areas of ethics, research, and practice.
CI  - Copyright (c) 2012. Published by Elsevier Ltd.
FAU - Klepac, Robert K
AU  - Klepac RK
AD  - University of Texas Health Science Center-San Antonio, TX 78250, USA.
      bobappic@mac.com
FAU - Ronan, George F
AU  - Ronan GF
FAU - Andrasik, Frank
AU  - Andrasik F
FAU - Arnold, Kevin D
AU  - Arnold KD
FAU - Belar, Cynthia D
AU  - Belar CD
FAU - Berry, Sharon L
AU  - Berry SL
FAU - Christofff, Karen A
AU  - Christofff KA
FAU - Craighead, Linda W
AU  - Craighead LW
FAU - Dougher, Michael J
AU  - Dougher MJ
FAU - Dowd, E Thomas
AU  - Dowd ET
FAU - Herbert, James D
AU  - Herbert JD
FAU - McFarr, Lynn M
AU  - McFarr LM
FAU - Rizvi, Shireen L
AU  - Rizvi SL
FAU - Sauer, Eric M
AU  - Sauer EM
FAU - Strauman, Timothy J
AU  - Strauman TJ
CN  - Inter-organizational Task Force on Cognitive and Behavioral Psychology Doctoral
      Education
LA  - eng
PT  - Guideline
PT  - Journal Article
DEP - 20120512
PL  - England
TA  - Behav Ther
JT  - Behavior therapy
JID - 1251640
SB  - IM
MH  - Advisory Committees
MH  - Cognitive Behavioral Therapy/*education
MH  - Curriculum/standards
MH  - Education, Graduate/*standards
MH  - Humans
MH  - Professional Competence/standards
MH  - Psychology/*education
MH  - United States
EDAT- 2012/10/11 06:00
MHDA- 2013/03/22 06:00
CRDT- 2012/10/11 06:00
PHST- 2012/04/17 00:00 [received]
PHST- 2012/04/29 00:00 [revised]
PHST- 2012/05/02 00:00 [accepted]
PHST- 2012/10/11 06:00 [entrez]
PHST- 2012/10/11 06:00 [pubmed]
PHST- 2013/03/22 06:00 [medline]
AID - S0005-7894(12)00064-0 [pii]
AID - 10.1016/j.beth.2012.05.002 [doi]
PST - ppublish
SO  - Behav Ther. 2012 Dec;43(4):687-97. doi: 10.1016/j.beth.2012.05.002. Epub 2012 May
      12.


PMID- 23046055
OWN - NLM
STAT- MEDLINE
DCOM- 20130418
LR  - 20181202
IS  - 1745-6584 (Electronic)
IS  - 0017-467X (Linking)
VI  - 50
IP  - 6
DP  - 2012 Nov-Dec
TI  - Chaos: without a conservation ethic for water.
PG  - 819
LID - 10.1111/j.1745-6584.2012.01004.x [doi]
FAU - Schwartz, Franklin W
AU  - Schwartz FW
LA  - eng
PT  - Editorial
PT  - Comment
DEP - 20121009
PL  - United States
TA  - Ground Water
JT  - Ground water
JID - 9882886
SB  - IM
CON - Ground Water. 2012 Nov-Dec;50(6):966-70. PMID: 23013116
MH  - *Conservation of Natural Resources
MH  - *Groundwater
MH  - *Hydrology
EDAT- 2012/10/11 06:00
MHDA- 2013/04/20 06:00
CRDT- 2012/10/11 06:00
PHST- 2012/10/11 06:00 [entrez]
PHST- 2012/10/11 06:00 [pubmed]
PHST- 2013/04/20 06:00 [medline]
AID - 10.1111/j.1745-6584.2012.01004.x [doi]
PST - ppublish
SO  - Ground Water. 2012 Nov-Dec;50(6):819. doi: 10.1111/j.1745-6584.2012.01004.x. Epub
      2012 Oct 9.


PMID- 23045895
OWN - NLM
STAT- MEDLINE
DCOM- 20121025
LR  - 20121010
IS  - 0033-2674 (Print)
IS  - 0033-2674 (Linking)
VI  - 46
IP  - 3
DP  - 2012 May-Jun
TI  - [Ethical problems in the treatment of schizophrenia].
PG  - 421-8
AB  - The authors present ethical dilemmas in the therapy, particularly family therapy,
      individual and group psychotherapy of schizophrenia in the context of the
      specific personality of persons suffering from schizophrenia as well as their
      experience
FAU - Kostecka, Malgorzata
AU  - Kostecka M
AD  - I Klinika Psychiatrii WUM.
FAU - Namyslowska, Irena
AU  - Namyslowska I
FAU - Ostoja-Zawadzka, Krystyna
AU  - Ostoja-Zawadzka K
LA  - pol
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Problemy etyczne w terapii schizofrenii.
PL  - Poland
TA  - Psychiatr Pol
JT  - Psychiatria polska
JID - 0103314
SB  - IM
MH  - Attitude of Health Personnel
MH  - *Ethics, Clinical
MH  - Family Therapy/*ethics
MH  - Humans
MH  - Professional Competence
MH  - Professional-Family Relations/*ethics
MH  - Professional-Patient Relations/*ethics
MH  - Psychotherapy/*ethics
MH  - Schizophrenia/*therapy
MH  - Vulnerable Populations/statistics & numerical data
EDAT- 2012/10/11 06:00
MHDA- 2012/10/26 06:00
CRDT- 2012/10/11 06:00
PHST- 2012/10/11 06:00 [entrez]
PHST- 2012/10/11 06:00 [pubmed]
PHST- 2012/10/26 06:00 [medline]
PST - ppublish
SO  - Psychiatr Pol. 2012 May-Jun;46(3):421-8.


PMID- 23045818
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20191112
IS  - 1679-4508 (Print)
IS  - 1679-4508 (Linking)
VI  - 10
IP  - 1
DP  - 2012 Jan-Mar
TI  - Compliance and leadership: the susceptibility of leaders to the risk of
      corruption in organizations.
PG  - 1-10
AB  - In the field of organizational management, the term "compliance" designates the
      set of actions to mitigate risk and prevent corruption. Programs are composed by 
      formal control systems, codes of ethics, educational actions, ombudsmen, and
      reporting channels--to mention the most recurrent, which vary according to the
      sector, the institutional culture, and the strategy. Leadership has a fundamental
      role in the process of compliance, not only due to its power to implement it, but
      precisely because it exercises this power, in itself, the object of reflections
      on ethics. The goal of this research was to evaluate the susceptibility of
      leaders to the risk of breaching organizational rules that involve ethical
      aspects. For quantitative investigation, we used social and descriptive
      statistical analysis of secondary data provided by ICTS Global, a company
      specialized in risk reduction. The study analyzed deals with non-probabilistic
      sampling by convenience, carried out between the years 2004 and 2008 with
      employees and candidates of 74 private companies located in Brazil. The final
      number of individuals studied is 7,267. The indicators analyzed are contained in 
      the index of moral perception of comprehension of individual vision of the
      concerning hypotheses of ethical conflicts. According to the information obtained
      in the investigation, leaders are more willing to fail to comply. Paradoxically, 
      the data also show that leaders are more loyal to organizations, raising the
      hypothesis that the bent toward moral integrity and loyalty to the organization
      are not necessarily simultaneous behaviors (it is possible that, motivated by
      loyalty, a leader might break away from individual principles). Based on the data
      and on bibliographic references, our final considerations point to the importance
      of considering systems from which leadership is recruited, compensated, promoted,
      developed, etc., in the prevention of corruption. Our data do not show that
      leaders are more corrupt, but that they have a greater disposition towards
      relaxing principles in professional circumstances.
FAU - dos Santos, Renato Almeida
AU  - dos Santos RA
AD  - Pontificia Universidade Catolica de Sao Paulo - PUC-SP, Sao Paulo (SP), Brazil.
FAU - Guevara, Arnoldo Jose de Hoyos
AU  - Guevara AJ
FAU - Amorim, Maria Cristina Sanches
AU  - Amorim MC
FAU - Ferraz-Neto, Ben-Hur
AU  - Ferraz-Neto BH
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Brazil
TA  - Einstein (Sao Paulo)
JT  - Einstein (Sao Paulo, Brazil)
JID - 101281800
SB  - IM
CIN - Einstein (Sao Paulo). 2012 Jan-Mar;10(1):ix-x. PMID: 23045817
MH  - Brazil
MH  - *Ethics, Institutional
MH  - *Guideline Adherence
MH  - Humans
MH  - *Leadership
MH  - Models, Theoretical
MH  - Morals
MH  - *Organizational Culture
MH  - Politics
MH  - *Professional Misconduct
MH  - Risk Reduction Behavior
EDAT- 2012/10/11 06:00
MHDA- 2012/11/14 06:00
CRDT- 2012/10/11 06:00
PHST- 2012/10/11 06:00 [entrez]
PHST- 2012/10/11 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
AID - S1679-45082012000100003 [pii]
AID - 10.1590/s1679-45082012000100003 [doi]
PST - ppublish
SO  - Einstein (Sao Paulo). 2012 Jan-Mar;10(1):1-10. doi:
      10.1590/s1679-45082012000100003.


PMID- 23045559
OWN - NLM
STAT- MEDLINE
DCOM- 20130107
LR  - 20220330
IS  - 1098-4275 (Electronic)
IS  - 0031-4005 (Linking)
VI  - 130
IP  - 5
DP  - 2012 Nov
TI  - Factors influencing participation in a population-based biorepository for
      childhood heart disease.
PG  - e1198-205
LID - 10.1542/peds.2012-0687 [doi]
AB  - BACKGROUND: Consenting minors for genetics research and biobanking involves
      ethical and social challenges. We examined factors influencing participation
      rates in a population-based biorepository for childhood heart disease. METHODS:
      Individuals were prospectively enrolled across 7 centers in Ontario by using a
      standardized consent form. Individuals were approached for consent for the
      donation of blood/saliva (DNA), tissue, and skin from the affected individual for
      future genomics and stem cell research. Consent rates were compared between
      pediatric and adult patients and factors affecting consent were analyzed by using
      multiple logistic regression analysis. RESULTS: From 2008 to 2011, 3637 patients 
      were approached. A total of 2717 pediatric patients consented (90% consent rate);
      mean age was 8.5 +/- 5.8 years (57% male; 76% white). A total of 561 adult
      patients consented (92% consent rate, P = .071 versus pediatric). Factors
      associated with lower pediatric consent rates included younger age, race, absence
      of complex defects, and location of consent; these were not associated with adult
      consent rates. Leading causes for refusal of consent were lack of interest in
      research (43%), overwhelmed clinically (14%), and discomfort with genetics (11%).
      Concerns related to privacy, insurability, indefinite storage, and ongoing access
      to medical records were not the leading causes for refusal. CONCLUSIONS: The high
      pediatric consent rate (90%) was comparable with that of adults. Ethical, social,
      or legal issues were not the leading reasons for refusal of consent.
FAU - Papaz, Tanya
AU  - Papaz T
AD  - Department of Paediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.
FAU - Safi, Mina
AU  - Safi M
FAU - Manickaraj, Ashok-Kumar
AU  - Manickaraj AK
FAU - Ogaki, Carly
AU  - Ogaki C
FAU - Breaton Kyryliuk, Jennifer
AU  - Breaton Kyryliuk J
FAU - Burrill, Liz
AU  - Burrill L
FAU - Dodge, Christine
AU  - Dodge C
FAU - Chant-Gambacort, Catherine
AU  - Chant-Gambacort C
FAU - Walter, Laura-Lee
AU  - Walter LL
FAU - Rosenberg, Herschel
AU  - Rosenberg H
FAU - Mondal, Tapas
AU  - Mondal T
FAU - Smythe, John
AU  - Smythe J
FAU - Lougheed, Jane
AU  - Lougheed J
FAU - Bergin, Lynn
AU  - Bergin L
FAU - Gordon, Elaine
AU  - Gordon E
FAU - Chitayat, David
AU  - Chitayat D
FAU - Oechslin, Erwin
AU  - Oechslin E
FAU - Mital, Seema
AU  - Mital S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20121008
PL  - United States
TA  - Pediatrics
JT  - Pediatrics
JID - 0376422
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Distribution
MH  - Aged
MH  - Aged, 80 and over
MH  - *Biological Specimen Banks
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - *Heart Diseases
MH  - Humans
MH  - Infant
MH  - Male
MH  - Middle Aged
MH  - Patient Participation/*statistics & numerical data
MH  - Prospective Studies
MH  - Young Adult
EDAT- 2012/10/10 06:00
MHDA- 2013/01/08 06:00
CRDT- 2012/10/10 06:00
PHST- 2012/10/10 06:00 [entrez]
PHST- 2012/10/10 06:00 [pubmed]
PHST- 2013/01/08 06:00 [medline]
AID - peds.2012-0687 [pii]
AID - 10.1542/peds.2012-0687 [doi]
PST - ppublish
SO  - Pediatrics. 2012 Nov;130(5):e1198-205. doi: 10.1542/peds.2012-0687. Epub 2012 Oct
      8.


PMID- 23045415
OWN - NLM
STAT- MEDLINE
DCOM- 20130821
LR  - 20121009
IS  - 1512-0112 (Print)
IS  - 1512-0112 (Linking)
IP  - 210
DP  - 2012 Sep
TI  - Legal and ethical issues in adolescents' health care.
PG  - 18-23
AB  - This review examines confidentiality, consent to health care and research
      involving adolescents in regard to legal and ethical aspects. Adolescents are
      more likely to seek health care if their provider assures confidentiality, but in
      providing confidential care a balance should be considered between the needs of
      the adolescent patient, parents, and provider. The vast majority of countries set
      the legal age at 18, but from the age of 14 years adolescents' capability for
      medical decision-making may be considered already similar to adult capacity.
      Instead of chronological age of consent, permission for consent must take into
      consideration the adolescent's capacity for understanding the medical treatment
      or the research in which the adolescent is requested to be involved. At all
      circumstances adolescent's assent for both medical treatment and research is
      always mandatory. Involving adolescents in research should be based on a careful 
      assessment of risks and benefits together with understanding of the developing
      capabilities of the adolescent.
FAU - Hardoff, D
AU  - Hardoff D
AD  - Adolescent Medicine Services of the Clalit Health Services, Israel.
LA  - eng
LA  - geo
PT  - Journal Article
PT  - Review
PL  - Georgia (Republic)
TA  - Georgian Med News
JT  - Georgian medical news
JID - 101218222
SB  - IM
MH  - Adolescent
MH  - Adolescent Health Services/*ethics/*legislation & jurisprudence
MH  - *Confidentiality
MH  - Ethics, Medical
MH  - Humans
MH  - *Informed Consent
EDAT- 2012/10/10 06:00
MHDA- 2013/08/22 06:00
CRDT- 2012/10/10 06:00
PHST- 2012/10/10 06:00 [entrez]
PHST- 2012/10/10 06:00 [pubmed]
PHST- 2013/08/22 06:00 [medline]
PST - ppublish
SO  - Georgian Med News. 2012 Sep;(210):18-23.


PMID- 23042886
OWN - NLM
STAT- MEDLINE
DCOM- 20121011
LR  - 20211203
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Linking)
VI  - 338
IP  - 6103
DP  - 2012 Oct 5
TI  - Are we getting closer to valid translational models for major depression?
PG  - 75-9
LID - 10.1126/science.1222940 [doi]
AB  - Advances in characterizing the neuropathology and functional dysconnectivity of
      depression and promising trials with emerging circuit-targeted and fast-onset
      therapeutics are providing unprecedented opportunities to gain deeper insight
      into the neurobiology of this devastating and pervasive disorder. Because of
      practical and ethical limitations to dissecting these mechanisms in humans,
      continued progress will critically depend on our ability to emulate aspects of
      depressive symptomatology and treatment response in nonhuman organisms. Although 
      various experimental models are currently available, they often draw skepticism
      from both clinicians and basic research scientists. We review recent progress and
      highlight some of the best leads to diversify and improve discovery end points
      for preclinical depression research.
FAU - Berton, Olivier
AU  - Berton O
AD  - Department of Psychiatry, Center for Neurobiology and Behavior, University of
      Pennsylvania, Philadelphia, PA 19104, USA. bertonol@mail.med.upenn.edu
FAU - Hahn, Chang-Gyu
AU  - Hahn CG
FAU - Thase, Michael E
AU  - Thase ME
LA  - eng
GR  - R01 MH087581/MH/NIMH NIH HHS/United States
GR  - MH087581/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
SB  - IM
MH  - Animals
MH  - Depressive Disorder, Major/*genetics/*physiopathology
MH  - *Disease Models, Animal
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Mice
MH  - Primates
MH  - *Translational Research, Biomedical
MH  - Zebrafish
EDAT- 2012/10/09 06:00
MHDA- 2012/10/12 06:00
CRDT- 2012/10/09 06:00
PHST- 2012/10/09 06:00 [entrez]
PHST- 2012/10/09 06:00 [pubmed]
PHST- 2012/10/12 06:00 [medline]
AID - 338/6103/75 [pii]
AID - 10.1126/science.1222940 [doi]
PST - ppublish
SO  - Science. 2012 Oct 5;338(6103):75-9. doi: 10.1126/science.1222940.


PMID- 23042793
OWN - NLM
STAT- MEDLINE
DCOM- 20160512
LR  - 20131025
IS  - 1464-3685 (Electronic)
IS  - 0300-5771 (Linking)
VI  - 42
IP  - 5
DP  - 2013 Oct
TI  - Cohort profile: The Stockholm Public Health Cohort.
PG  - 1263-72
LID - 10.1093/ije/dys126 [doi]
AB  - The Stockholm Public Health Cohort was set up within the Stockholm County Council
      public health surveys to inform on determinants and consequences of significant
      contributors to the current burden of disease. Participants are 89 268 randomly
      selected individuals from the adult population of Stockholm County. Baseline
      surveys took place in 2002, 2006 and 2010 via self-administered questionnaires.
      So far, participants recruited in 2002 were re-surveyed twice, in 2007 and 2010, 
      and those enrolled in 2006 were re-surveyed once, in 2010. Self-reported data are
      regularly supplemented by information from national and regional health data and 
      administrative registers, for study participants and their relatives (including
      their offspring). Available data are extensive and include a wide array of
      health, lifestyle, perinatal, demographic, socio-economic and familial factors.
      The cohort is an international resource for epidemiological research, and the
      data available to the research community for specific studies obtained approval
      from the Stockholm Public Health Cohort Steering Committee and the Stockholm
      Regional Ethical Review Board.
FAU - Svensson, Anna C
AU  - Svensson AC
AD  - Division of Public Health Epidemiology, Department of Public Health Sciences,
      Karolinska Institutet, Stockholm, Sweden, Centre for Epidemiology and Community
      Medicine, Stockholm County Council, Stockholm, Sweden, Division of Global Health 
      (IHCAR), Department of Public Health Sciences, Karolinska Institutet, Stockholm, 
      Sweden, Department of Public Health and Caring Sciences, Uppsala University,
      Uppsala, Sweden, Institute of Environmental Medicine, Karolinska Institutet,
      Stockholm, Sweden, Unit of Clinical Epidemiology, Department of Medicine,
      Karolinska Institutet, Stockholm, Sweden, Department of Development, Stockholm
      County Council, Stockholm, Sweden, Department of Medical Epidemiology and
      Biostatistics, Karolinska Institutet, Stockholm, Sweden and CHESS-Centre for
      Health Equity Studies, Stockholm University/Karolinska Institutet, Stockholm,
      Sweden.
FAU - Fredlund, Peeter
AU  - Fredlund P
FAU - Laflamme, Lucie
AU  - Laflamme L
FAU - Hallqvist, Johan
AU  - Hallqvist J
FAU - Alfredsson, Lars
AU  - Alfredsson L
FAU - Ekbom, Anders
AU  - Ekbom A
FAU - Feychting, Maria
AU  - Feychting M
FAU - Forsberg, Birger
AU  - Forsberg B
FAU - Pedersen, Nancy L
AU  - Pedersen NL
FAU - Vagero, Denny
AU  - Vagero D
FAU - Magnusson, Cecilia
AU  - Magnusson C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121005
PL  - England
TA  - Int J Epidemiol
JT  - International journal of epidemiology
JID - 7802871
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alcohol Drinking/epidemiology
MH  - Cohort Studies
MH  - Diet/*statistics & numerical data
MH  - Female
MH  - Health Status
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Mental Disorders/*epidemiology
MH  - Middle Aged
MH  - Overweight/*epidemiology
MH  - *Public Health Surveillance
MH  - Smoking/*epidemiology
MH  - *Social Class
MH  - Stress, Psychological/epidemiology
MH  - Surveys and Questionnaires
MH  - Sweden/epidemiology
MH  - Young Adult
OTO - NOTNLM
OT  - Public health
OT  - cohort studies
OT  - data collection
OT  - epidemiology
OT  - health surveys
OT  - questionnaires
EDAT- 2012/10/09 06:00
MHDA- 2016/05/14 06:00
CRDT- 2012/10/09 06:00
PHST- 2012/10/09 06:00 [entrez]
PHST- 2012/10/09 06:00 [pubmed]
PHST- 2016/05/14 06:00 [medline]
AID - dys126 [pii]
AID - 10.1093/ije/dys126 [doi]
PST - ppublish
SO  - Int J Epidemiol. 2013 Oct;42(5):1263-72. doi: 10.1093/ije/dys126. Epub 2012 Oct
      5.


PMID- 23042065
OWN - NLM
STAT- MEDLINE
DCOM- 20130201
LR  - 20141120
IS  - 1538-6899 (Electronic)
IS  - 1080-2371 (Linking)
VI  - 18
IP  - 5 Neuro-otology
DP  - 2012 Oct
TI  - Grounded for an ethical dilemma: disequilibrium in a commercial airline pilot.
PG  - 1158-62
LID - 10.1212/01.CON.0000421624.64148.5a [doi]
AB  - This article presents the case of a 41-year-old airline pilot with benign
      paroxysmal positional vertigo who requests that his diagnosis not be disclosed to
      his commercial airline employer or his aviation medical examiner because it may
      result in the suspension of medical certification. The legal and ethical
      requirements for physicians reporting impaired pilots are discussed as well as
      practical recommendations for handling such situations. The argument is made that
      a physician's obligation to honor patient confidentiality should not take
      precedence over his or her duty to protect the safety and well-being of the
      airplane passengers and the general public. If the patient chooses not to
      self-report, a physician has an ethical obligation to report the patient's
      medical condition to the Federal Aviation Administration.
FAU - Kirschen, Matthew P
AU  - Kirschen MP
AD  - Children's Hospital of Philadelphia, 34th and Civic Center Boulevard,
      Philadelphia, PA 19104, USA. kirschenm@email.chop.edu
FAU - Friedlander, Joel A
AU  - Friedlander JA
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Continuum (Minneap Minn)
JT  - Continuum (Minneapolis, Minn.)
JID - 9509333
SB  - IM
MH  - Adult
MH  - Aerospace Medicine/*ethics/legislation & jurisprudence
MH  - Benign Paroxysmal Positional Vertigo
MH  - Certification/ethics/legislation & jurisprudence
MH  - Duty to Warn/ethics/legislation & jurisprudence
MH  - Ethics, Medical
MH  - Humans
MH  - Male
MH  - Neurotology/*ethics/legislation & jurisprudence
MH  - Occupational Medicine/*ethics/legislation & jurisprudence
MH  - Truth Disclosure/*ethics
MH  - *Vertigo
EDAT- 2012/10/09 06:00
MHDA- 2013/02/05 06:00
CRDT- 2012/10/09 06:00
PHST- 2012/10/09 06:00 [entrez]
PHST- 2012/10/09 06:00 [pubmed]
PHST- 2013/02/05 06:00 [medline]
AID - 10.1212/01.CON.0000421624.64148.5a [doi]
AID - 00132979-201210000-00014 [pii]
PST - ppublish
SO  - Continuum (Minneap Minn). 2012 Oct;18(5 Neuro-otology):1158-62. doi:
      10.1212/01.CON.0000421624.64148.5a.


PMID- 23041321
OWN - NLM
STAT- MEDLINE
DCOM- 20131202
LR  - 20181202
IS  - 1578-1291 (Electronic)
IS  - 1130-2399 (Linking)
VI  - 23
IP  - 4
DP  - 2012 Oct-Dec
TI  - [Mechanical restraint: its use in intensive cares].
PG  - 164-70
LID - 10.1016/j.enfi.2012.08.002 [doi]
LID - S1130-2399(12)00072-7 [pii]
AB  - OBJECTIVE: To analyze the impact of the use of mechanical restraint (MR) or
      physical restraints in a Critical Care unit and to evaluate the procedure. BASIC 
      PROCEDURES: A descriptive, prospective study. INCLUSION CRITERIA: patients who
      required MR from March to June 2010. VARIABLES: demographic, clinical
      presentation, indications, techniques and devices. A statistical analysis with
      mean, standard deviation and percentages using the program SPSS 14.0. RESULTS: A 
      total of 85 cases were studied: 65.9% male, mean age 64.19 (+/-17.9), NEMS 29.3
      (+/-8.2). Incidence of MR: 15.6%. Main indication for MR: Risk of serious
      disruption of treatment processes (80%). Decision nurse (94.1%). Urgent action:
      (85.9%). Registration procedure: 57.6%. Information to the family: 9.4%. Previous
      actions: verbal containment (100%), pharmacological (48.2%). CONCLUSIONS: There
      is a relevant incidence of MR. The principal reason is that of avoiding
      interruption of the therapeutic process. The nurse makes the initial decision.
      Necessary information/training of professionals for legal and ethical
      repercussions is needed.
CI  - Copyright (c) 2011 Elsevier Espana, S.L. y SEEIUC. All rights reserved.
FAU - Martin Iglesias, V
AU  - Martin Iglesias V
AD  - Unidad de Criticos II, Servicio de Medicina Intensiva, Hospital Clinico San
      Carlos, (HCSC), Madrid, Espana. tayrailf_3@yahoo.es
FAU - Ponton Soriano, C
AU  - Ponton Soriano C
FAU - Quintian Guerra, M T
AU  - Quintian Guerra MT
FAU - Velasco Sanz, T R
AU  - Velasco Sanz TR
FAU - Merino Martinez, M R
AU  - Merino Martinez MR
FAU - Simon Garcia, M J
AU  - Simon Garcia MJ
FAU - Gonzalez Sanchez, J A
AU  - Gonzalez Sanchez JA
LA  - spa
PT  - Journal Article
TT  - Contencion mecanica: su uso en cuidados intensivos.
DEP - 20121005
PL  - Spain
TA  - Enferm Intensiva
JT  - Enfermeria intensiva
JID - 9517771
MH  - Critical Care/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Records
MH  - Restraint, Physical/*statistics & numerical data
EDAT- 2012/10/09 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/10/09 06:00
PHST- 2011/12/23 00:00 [received]
PHST- 2012/04/16 00:00 [revised]
PHST- 2012/08/20 00:00 [accepted]
PHST- 2012/10/09 06:00 [entrez]
PHST- 2012/10/09 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - S1130-2399(12)00072-7 [pii]
AID - 10.1016/j.enfi.2012.08.002 [doi]
PST - ppublish
SO  - Enferm Intensiva. 2012 Oct-Dec;23(4):164-70. doi: 10.1016/j.enfi.2012.08.002.
      Epub 2012 Oct 5.


PMID- 23040790
OWN - NLM
STAT- MEDLINE
DCOM- 20130513
LR  - 20121116
IS  - 1769-6623 (Electronic)
IS  - 0750-7658 (Linking)
VI  - 31
IP  - 11
DP  - 2012 Nov
TI  - [Medication errors in anesthesia: a Moroccan university hospitals survey].
PG  - 863-9
LID - 10.1016/j.annfar.2012.07.024 [doi]
LID - S0750-7658(12)00360-7 [pii]
AB  - INTRODUCTION: Medication errors are a major public health problem because of
      their morbidity and financial costs. In anesthesia, few articles publications,
      mostly retrospective, have assessed its incidence and outcomes. By our
      prospective study, we intend to identify and describe the drug errors in
      anesthesia in four university hospitals in Morocco. MATERIAL AND METHODS: After
      approval of our ethics committee, a prospective study was conducted in nine
      hospitals affiliated to four university hospitals (Rabat, Casablanca, Fes and
      Marrakech) from October 2009 to June 2010. Data collection was carried out by an 
      anesthesiologist at each hospital who was designated by the investigator.
      Informations were based on practitioner's statements. Medication errors were
      divided into distinct categories: substitution errors, omission errors, errors of
      the way of administration, dosage and dilution errors. The consequences were
      classified into four levels according to their severity. RESULTS: During the
      study period, 9199 anesthetic procedures were reported (mean response of 36%).
      General anesthesia was performed in 75% of patients. Sixteen cases of drug errors
      were reported (an incidence of 1/575 with 1/405 in a pediatric setting). The
      drugs involved were dominated by hypnotics (six cases/16) and morphine (four
      cases/16). Medication errors were mainly due to labeling mistakes (seven
      cases/16) and to attention deficit due to fatigue and stress (seven other cases) 
      leading to substitution error in most of cases (10 cases/16. Errors were mainly
      made by the less experienced practitioners (14 cases/16). They occurred during
      the induction phase (seven cases/16) as well as during the interview process
      (nine cases/16), and also during emergent surgeries (seven errors/16) as well as 
      during elective ones (nine errors/16). No errors caused death. Pulmonary edema
      (recognized as a grade III severity incident) was secondary to inappropriate
      administration of adrenaline. CONCLUSION: Our study helped us to set
      recommendations, which are approved by the Moroccan pharmacovigilance center, and
      in accordance with the international committees to prevent the occurrence of
      medication errors in our daily anesthetic practice.
CI  - Copyright (c) 2012. Published by Elsevier SAS.
FAU - Amor, M
AU  - Amor M
AD  - Departement d'anesthesie et de reanimation, CHU Ibn Sina, Rabat, Maroc.
      mourad_amor_rea@yahoo.fr
FAU - Bensghir, M
AU  - Bensghir M
FAU - Belkhadir, Z
AU  - Belkhadir Z
FAU - Ghannam, A
AU  - Ghannam A
FAU - Azendour, H
AU  - Azendour H
FAU - Drissi Kamili, N
AU  - Drissi Kamili N
FAU - Maazouzi, W
AU  - Maazouzi W
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Erreurs medicamenteuses en anesthesie : enquete prospective au niveau des CHU
      Marocains.
DEP - 20121003
PL  - France
TA  - Ann Fr Anesth Reanim
JT  - Annales francaises d'anesthesie et de reanimation
JID - 8213275
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Anesthesia
MH  - Child
MH  - Child, Preschool
MH  - *Hospitals, University
MH  - Humans
MH  - Infant
MH  - Medication Errors/*statistics & numerical data
MH  - Middle Aged
MH  - Morocco
MH  - Prospective Studies
MH  - Young Adult
EDAT- 2012/10/09 06:00
MHDA- 2013/05/15 06:00
CRDT- 2012/10/09 06:00
PHST- 2011/10/21 00:00 [received]
PHST- 2012/07/28 00:00 [accepted]
PHST- 2012/10/09 06:00 [entrez]
PHST- 2012/10/09 06:00 [pubmed]
PHST- 2013/05/15 06:00 [medline]
AID - S0750-7658(12)00360-7 [pii]
AID - 10.1016/j.annfar.2012.07.024 [doi]
PST - ppublish
SO  - Ann Fr Anesth Reanim. 2012 Nov;31(11):863-9. doi: 10.1016/j.annfar.2012.07.024.
      Epub 2012 Oct 3.


PMID- 23040708
OWN - NLM
STAT- MEDLINE
DCOM- 20130524
LR  - 20121211
IS  - 1873-6386 (Electronic)
IS  - 0160-2527 (Linking)
VI  - 35
IP  - 5-6
DP  - 2012 Sep-Dec
TI  - Planning, writing, and editing forensic psychiatric reports.
PG  - 412-7
LID - 10.1016/j.ijlp.2012.09.019 [doi]
LID - S0160-2527(12)00082-9 [pii]
AB  - Forensic psychiatric reports are often the final product of a psychiatrist's work
      in a particular case because most cases do not go to trial but instead are
      settled through negotiation or plea bargaining. This article addresses the
      planning, writing, and editing of forensic reports. Planning a report requires
      thorough data gathering, and thoughtful organization of the report into specific 
      subheadings. Throughout the report there should be a clear separation of factual 
      data from professional opinions. Ten pitfalls of report writing are identified.
      The most important part of the forensic report is the opinion section. The
      evidence for the opinion should begin with the strongest points and the reasons
      supporting the opinion should be completely explained. Finally, ethical issues
      are addressed.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Resnick, Phillip J
AU  - Resnick PJ
AD  - Case Western Reserve University, School of Medicine, 10524 Euclid Ave.,
      Cleveland, OH 44106, United States. phillip.resnick@case.edu
FAU - Soliman, Sherif
AU  - Soliman S
LA  - eng
PT  - Journal Article
DEP - 20121003
PL  - Netherlands
TA  - Int J Law Psychiatry
JT  - International journal of law and psychiatry
JID - 7806862
SB  - IM
MH  - Documentation/*methods
MH  - *Forensic Psychiatry
MH  - Humans
MH  - United States
MH  - *Writing
EDAT- 2012/10/09 06:00
MHDA- 2013/05/28 06:00
CRDT- 2012/10/09 06:00
PHST- 2012/10/09 06:00 [entrez]
PHST- 2012/10/09 06:00 [pubmed]
PHST- 2013/05/28 06:00 [medline]
AID - S0160-2527(12)00082-9 [pii]
AID - 10.1016/j.ijlp.2012.09.019 [doi]
PST - ppublish
SO  - Int J Law Psychiatry. 2012 Sep-Dec;35(5-6):412-7. doi:
      10.1016/j.ijlp.2012.09.019. Epub 2012 Oct 3.


PMID- 23040706
OWN - NLM
STAT- MEDLINE
DCOM- 20130524
LR  - 20121211
IS  - 1873-6386 (Electronic)
IS  - 0160-2527 (Linking)
VI  - 35
IP  - 5-6
DP  - 2012 Sep-Dec
TI  - Why did so many German doctors join the Nazi Party early?
PG  - 473-9
LID - 10.1016/j.ijlp.2012.09.022 [doi]
LID - S0160-2527(12)00085-4 [pii]
AB  - During the Weimar Republic in the mid-twentieth century, more than half of all
      German physicians became early joiners of the Nazi Party, surpassing the party
      enrollments of all other professions. From early on, the German Medical Society
      played the most instrumental role in the Nazi medical program, beginning with the
      marginalization of Jewish physicians, proceeding to coerced "experimentation,"
      "euthanization," and sterilization, and culminating in genocide via the
      medicalization of mass murder of Jews and others caricatured and demonized by
      Nazi ideology. Given the medical oath to "do no harm," many postwar ethical
      analyses have strained to make sense of these seemingly paradoxical atrocities.
      Why did physicians act in such a manner? Yet few have tried to explain the
      self-selected Nazi enrollment of such an overwhelming proportion of the German
      Medical Society in the first place. This article lends insight into this paradox 
      by exploring some major vulnerabilities, motives, and rationalizations that may
      have predisposed German physicians to Nazi membership-professional
      vulnerabilities among physicians in general (valuing conformity and obedience to 
      authority, valuing the prevention of contamination and fighting against
      mortality, and possessing a basic interest in biomedical knowledge and research),
      economic factors and motives (related to physician economic insecurity and
      incentives for economic advancement), and Nazi ideological and historical
      rationalizations (beliefs about Social Darwinism, eugenics, and the social
      organism as sacred). Of particular significance for future research and education
      is the manner in which the persecution of Jewish physician colleagues was
      rationalized in the name of medical ethics itself. Giving proper consideration to
      the forces that fueled "Nazi Medicine" is of great importance, as it can
      highlight the conditions and motivations that make physicians susceptible to
      misapplications of medicine, and guide us toward prevention of future abuse.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Haque, Omar S
AU  - Haque OS
AD  - Program in Psychiatry and the Law, Harvard Medical School, 96 Larchwood Drive,
      Cambridge, MA 02138, USA.
FAU - De Freitas, Julian
AU  - De Freitas J
FAU - Viani, Ivana
AU  - Viani I
FAU - Niederschulte, Bradley
AU  - Niederschulte B
FAU - Bursztajn, Harold J
AU  - Bursztajn HJ
LA  - eng
PT  - Historical Article
PT  - Journal Article
DEP - 20121003
PL  - Netherlands
TA  - Int J Law Psychiatry
JT  - International journal of law and psychiatry
JID - 7806862
SB  - IM
MH  - *Decision Making
MH  - Germany
MH  - Hippocratic Oath
MH  - History, 20th Century
MH  - Holocaust
MH  - Humans
MH  - *National Socialism/history
MH  - Physicians/economics/*ethics/psychology
MH  - Social Change/history
EDAT- 2012/10/09 06:00
MHDA- 2013/05/28 06:00
CRDT- 2012/10/09 06:00
PHST- 2012/10/09 06:00 [entrez]
PHST- 2012/10/09 06:00 [pubmed]
PHST- 2013/05/28 06:00 [medline]
AID - S0160-2527(12)00085-4 [pii]
AID - 10.1016/j.ijlp.2012.09.022 [doi]
PST - ppublish
SO  - Int J Law Psychiatry. 2012 Sep-Dec;35(5-6):473-9. doi:
      10.1016/j.ijlp.2012.09.022. Epub 2012 Oct 3.


PMID- 23039941
OWN - NLM
STAT- MEDLINE
DCOM- 20140204
LR  - 20130513
IS  - 1532-3099 (Electronic)
IS  - 0266-6138 (Linking)
VI  - 29
IP  - 6
DP  - 2013 Jun
TI  - Perceived Breastfeeding Support Assessment Tool (PBSAT): development and testing 
      of psychometric properties with Pakistani urban working mothers.
PG  - 599-607
LID - 10.1016/j.midw.2012.05.003 [doi]
LID - S0266-6138(12)00074-5 [pii]
AB  - INTRODUCTION: breast feeding is an essential source of nutrition among young
      babies; however, in Pakistan a gradual decline in prevalence of breast feeding,
      especially among urban working mothers, has been reported. Previous studies among
      Pakistani urban working mothers have revealed that ensuring exclusivity and
      continuation of breast feeding is challenging if social and/or workplace
      environmental support is minimal or absent. This problem indicated a crucial need
      to assess availability of breast-feeding support for Pakistani urban working
      mothers by using a comprehensive, reliable, and validated tool in their national 
      language (Urdu). PURPOSE: to develop and test the psychometric properties of the 
      'Perceived Breastfeeding Support Assessment Tool' (PBSAT) that can gauge
      Pakistani urban working mothers' perceptions about breast-feeding support.
      METHODOLOGY: this methodological research was undertaken in five phases. During
      phase I, a preliminary draft of the PBSAT was developed by using the
      Socio-ecological model, reviewing literature, and referring to two United States 
      based tools. In Phase II, the instrument was evaluated by seven different
      experts, and, in Phase III, the instrument was revised, translated, and back
      translated. In Phase IV, the tool was pilot tested among 20 participants and then
      modified on the basis of statistical analysis. In Phase V, the refined instrument
      was tested on 200 breast-feeding working mothers recruited through purposive
      sampling from the government and private health-care settings in Karachi,
      Pakistan. Approvals were received from the Ethical Review Committees of the
      identified settings. FINDINGS: the 29-item based PBSAT revealed an acceptable
      inter-rater reliability of 0.95, and an internal consistency reliability
      coefficient (Cronbach's alpha) of 0.85. A construct validity assessment through
      Exploratory Factor Analysis revealed that the PBSAT has two dimensions,
      'workplace environmental support' (12 items; alpha=0.86) and 'social
      environmental support' (17 items; alpha=0.77). CONCLUSION: the study developed a 
      29-item based two-dimensional tool (in Urdu) that has acceptable psychometric
      properties. The PBSAT is context specific, comprehensive, and user-friendly, so
      it can be administered by health-care workers, employers, policy makers, and
      researchers to improve the quality of services of breast-feeding urban working
      mothers, and could ultimately improve child health in Pakistan.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Hirani, Shela Akbar Ali
AU  - Hirani SA
AD  - School of Nursing and Midwifery, Aga Khan University, Stadium Road, Karachi,
      Sindh 3500, Pakistan. shela.hirani@aku.edu
FAU - Karmaliani, Rozina
AU  - Karmaliani R
FAU - Christie, Thomas
AU  - Christie T
FAU - Parpio, Yasmin
AU  - Parpio Y
FAU - Rafique, Ghazala
AU  - Rafique G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121003
PL  - Scotland
TA  - Midwifery
JT  - Midwifery
JID - 8510930
MH  - Adult
MH  - Breast Feeding/*psychology
MH  - Female
MH  - Humans
MH  - Maternal Behavior/*psychology
MH  - Mothers/psychology
MH  - Pakistan
MH  - *Postnatal Care/methods/standards
MH  - *Psychometrics/methods/standards
MH  - Reproducibility of Results
MH  - Research Design
MH  - Social Perception
MH  - *Social Support
MH  - Social Validity, Research
MH  - Socioeconomic Factors
MH  - Urban Population
MH  - Women, Working
EDAT- 2012/10/09 06:00
MHDA- 2014/02/05 06:00
CRDT- 2012/10/09 06:00
PHST- 2012/01/31 00:00 [received]
PHST- 2012/05/11 00:00 [revised]
PHST- 2012/05/12 00:00 [accepted]
PHST- 2012/10/09 06:00 [entrez]
PHST- 2012/10/09 06:00 [pubmed]
PHST- 2014/02/05 06:00 [medline]
AID - S0266-6138(12)00074-5 [pii]
AID - 10.1016/j.midw.2012.05.003 [doi]
PST - ppublish
SO  - Midwifery. 2013 Jun;29(6):599-607. doi: 10.1016/j.midw.2012.05.003. Epub 2012 Oct
      3.


PMID- 23039306
OWN - NLM
STAT- MEDLINE
DCOM- 20130521
LR  - 20211021
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 13
DP  - 2012 Oct 5
TI  - Evaluation of a real-time virtual intervention to empower persons living with HIV
      to use therapy self-management: study protocol for an online randomized
      controlled trial.
PG  - 187
LID - 10.1186/1745-6215-13-187 [doi]
AB  - BACKGROUND: Living with HIV makes considerable demands on a person in terms of
      self-management, especially as regards adherence to treatment and coping with
      adverse side-effects. The online HIV Treatment, Virtual Nursing Assistance and
      Education (Virus de I'immunodeficience Humaine-Traitement Assistance Virtuelle
      Infirmiere et Enseignement; VIH-TAVIE) intervention was developed to provide
      persons living with HIV (PLHIV) with personalized follow-up and real-time support
      in managing their medication intake on a daily basis. An online randomized
      controlled trial (RCT) will be conducted to evaluate the efficacy of this
      intervention primarily in optimizing adherence to combination anti-retroviral
      therapy (ART) among PLHIV. METHODS/DESIGN: A convenience sample of 232 PLHIV will
      be split evenly and randomly between an experimental group that will use the web 
      application, and a control group that will be handed a list of websites of
      interest. Participants must be aged 18 years or older, have been on ART for at
      least 6 months, and have internet access. The intervention is composed of four
      interactive computer sessions of 20 to 30 minutes hosted by a virtual nurse who
      engages the PLHIV in a skills-learning process aimed at improving self-management
      of medication intake. Adherence constitutes the principal outcome, and is defined
      as the intake of at least 95% of the prescribed tablets. The following
      intermediary measures will be assessed: self-efficacy and attitude towards
      antiretroviral medication, symptom-related discomfort, and emotional support.
      There will be three measurement times: baseline (T0), after 3 months (T3) and 6
      months (T6) of baseline measurement. The principal analyses will focus on
      comparing the two groups in terms of treatment adherence at the end of follow-up 
      at T6. An intention-to-treat (ITT) analysis will be carried out to evaluate the
      true value of the intervention in a real context. DISCUSSION: Carrying out this
      online RCT poses various challenges in terms of recruitment, ethics, and data
      collection, including participant follow-up over an extended period.
      Collaboration between researchers from clinical disciplines (nursing, medicine), 
      and experts in behavioral sciences information technology and media will be
      crucial to the development of innovative solutions to supplying and delivering
      health services. TRIAL REGISTRATION: CE 11.184 / NCT 01510340.
FAU - Cote, Jose
AU  - Cote J
AD  - Research Chair in Innovative Nursing Practices, Research Centre of the Centre
      Hospitalier de l'Universite de Montreal, Quebec, Canada. jose.cote@umontreal.ca
FAU - Godin, Gaston
AU  - Godin G
FAU - Gueheneuc, Yann-Gael
AU  - Gueheneuc YG
FAU - Rouleau, Genevieve
AU  - Rouleau G
FAU - Ramirez-Garcia, Pilar
AU  - Ramirez-Garcia P
FAU - Otis, Joanne
AU  - Otis J
FAU - Tremblay, Cecile
AU  - Tremblay C
FAU - Fadel, Ghayas
AU  - Fadel G
LA  - eng
SI  - ClinicalTrials.gov/NCT01510340
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20121005
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - Adaptation, Psychological
MH  - Anti-HIV Agents/adverse effects/*therapeutic use
MH  - Cost of Illness
MH  - *Drug Therapy, Computer-Assisted
MH  - Emotions
MH  - HIV Infections/diagnosis/*drug therapy/nursing/psychology
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Intention to Treat Analysis
MH  - Internet
MH  - *Medication Adherence
MH  - Nurse-Patient Relations
MH  - *Power, Psychological
MH  - Quebec
MH  - *Research Design
MH  - *Self Care
MH  - Self Efficacy
MH  - Social Support
MH  - Time Factors
MH  - Treatment Outcome
MH  - User-Computer Interface
PMC - PMC3519569
EDAT- 2012/10/09 06:00
MHDA- 2013/05/23 06:00
CRDT- 2012/10/09 06:00
PHST- 2012/02/14 00:00 [received]
PHST- 2012/09/21 00:00 [accepted]
PHST- 2012/10/09 06:00 [entrez]
PHST- 2012/10/09 06:00 [pubmed]
PHST- 2013/05/23 06:00 [medline]
AID - 1745-6215-13-187 [pii]
AID - 10.1186/1745-6215-13-187 [doi]
PST - epublish
SO  - Trials. 2012 Oct 5;13:187. doi: 10.1186/1745-6215-13-187.


PMID- 23039162
OWN - NLM
STAT- MEDLINE
DCOM- 20131202
LR  - 20151119
IS  - 1365-2702 (Electronic)
IS  - 0962-1067 (Linking)
VI  - 22
IP  - 5-6
DP  - 2013 Mar
TI  - A worldwide investigation of critical care research coordinators' self-reported
      role and professional development priorities: the winner survey.
PG  - 838-47
LID - 10.1111/j.1365-2702.2012.04230.x [doi]
AB  - AIMS AND OBJECTIVES: To describe the self-reported role and professional
      development priorities of research coordinators in different regions of the
      world. BACKGROUND: Research coordinators employed in critical care settings
      provide clinical and technical expertise in the development, conduct and
      completion of clinical research studies. Knowledge of this specialised role is
      well established in some parts of the world, yet emerging in others. DESIGN:
      Descriptive exploratory study involving research coordinators outside of
      Australia and New Zealand. METHOD: An anonymous, structured, multiple-choice,
      web-based questionnaire conducted between April-May 2011. RESULTS: There were 80 
      respondents from North America (61%), Europe (29%) and Latin America (10%). The
      majority of respondents performed data collection and obtained informed consent, 
      and half had presented study findings at conferences or wrote scholarly articles,
      despite a greater willingness to do so. Requisite skills for the research
      coordinator role included clinical research knowledge, creative problem solving
      and the ability to identify/resolve ethical questions. 'Best' reported aspects of
      the role were promotion of evidence-based clinical practice, intellectual
      stimulation and autonomy. 'Worst' aspects included heavy workload, lack of
      funding and recognition. CONCLUSION: Research coordinators working in critical
      care settings collect data, require clinical research knowledge and
      problem-solving skills and are interested in, but have less confidence in,
      dissemination of research findings. They feel isolated with a lack of support and
      inadequate remuneration for the effort and time required to maintain the high
      standards of their role. This is outweighed by the satisfaction derived from
      promoting the research process and autonomy. Further observational studies aimed 
      at clarifying and advancing the role of the research coordinator is warranted.
      RELEVANCE TO CLINICAL PRACTICE: This study offers insight into the global roles
      and responsibilities as reported by research coordinators employed in critical
      care settings.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Eastwood, Glenn M
AU  - Eastwood GM
AD  - Department of Intensive Care, Austin Hospital, Heidelberg, Vic, Australia.
      glenn.eastwood@austin.org.au
FAU - Roberts, Brigit
AU  - Roberts B
FAU - Williams, Ged
AU  - Williams G
FAU - Rickard, Claire M
AU  - Rickard CM
LA  - eng
PT  - Journal Article
DEP - 20121008
PL  - England
TA  - J Clin Nurs
JT  - Journal of clinical nursing
JID - 9207302
MH  - Adult
MH  - Australia
MH  - Cohort Studies
MH  - *Critical Care
MH  - Data Collection
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - New Zealand
MH  - *Research Personnel
MH  - *Staff Development
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2012/10/09 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/10/09 06:00
PHST- 2012/10/09 06:00 [entrez]
PHST- 2012/10/09 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1111/j.1365-2702.2012.04230.x [doi]
PST - ppublish
SO  - J Clin Nurs. 2013 Mar;22(5-6):838-47. doi: 10.1111/j.1365-2702.2012.04230.x. Epub
      2012 Oct 8.


PMID- 23038878
OWN - NLM
STAT- MEDLINE
DCOM- 20121102
LR  - 20191027
IS  - 0037-8046 (Print)
IS  - 0037-8046 (Linking)
VI  - 57
IP  - 2
DP  - 2012 Apr
TI  - Deaths in the desert: the human rights crisis on the U.S.-Mexico border.
PG  - 165-73
AB  - Many would acknowledge that immigration is a major issue in the United States and
      that immigration reform should be a priority. However, there is little attention 
      to the human rights crisis on the U.S.-Mexican border. As a result of tightened
      border security since 1994, it is estimated that over 5,000 migrants have died in
      the Sonoran desert. The criminalization of immigration has resulted in a human
      rights crisis in three areas: (1) the rise of deaths and injuries of migrants
      crossing the border in harsh and remote locations, (2) the use of mass hearings
      to prosecute apprehended migrants, and (3) abuses of migrants in immigration
      detention. These policies and practices have serious repercussions for the
      affected vulnerable population. Despite recent legislation designed to discourage
      undocumented immigration, such as Arizona's Senate Bill 1070, the deterrence
      strategy has not diminished migration--it has only increased the suffering and
      deaths of migrants. Humanitarian groups are working to prevent more deaths but
      also have been targeted for criminalization. The profession's ethics compel
      social workers to work with humanitarian organizations to prevent more deaths and
      to advocate for humane immigration reform.
FAU - Androff, David K
AU  - Androff DK
AD  - School of Social Work, Arizona State University, Phoenix, AZ 85004, USA.
      david.androff@asu.edu
FAU - Tavassoli, Kyoko Y
AU  - Tavassoli KY
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Soc Work
JT  - Social work
JID - 2984852R
SB  - IM
MH  - Emigration and Immigration/*legislation & jurisprudence
MH  - *Human Rights
MH  - Humans
MH  - Mexico
MH  - *Mortality
MH  - Public Policy
MH  - *Social Work
MH  - *Transients and Migrants/statistics & numerical data
MH  - United States
MH  - Vulnerable Populations
EDAT- 2012/10/09 06:00
MHDA- 2012/11/03 06:00
CRDT- 2012/10/09 06:00
PHST- 2012/10/09 06:00 [entrez]
PHST- 2012/10/09 06:00 [pubmed]
PHST- 2012/11/03 06:00 [medline]
AID - 10.1093/sw/sws034 [doi]
PST - ppublish
SO  - Soc Work. 2012 Apr;57(2):165-73. doi: 10.1093/sw/sws034.


PMID- 23038877
OWN - NLM
STAT- MEDLINE
DCOM- 20121102
LR  - 20191027
IS  - 0037-8046 (Print)
IS  - 0037-8046 (Linking)
VI  - 57
IP  - 2
DP  - 2012 Apr
TI  - American Bar Association Supplementary Guidelines for the Mitigation Function of 
      Defense Teams in Death Penalty Cases: implications for social work.
PG  - 155-64
AB  - When a client faces a penalty of death, defense attorneys may call on social
      workers in many capacities: mitigation specialist, expert witness, consulting
      specialist, direct witness, or defense-initiated victim outreach worker. The
      American Bar Association set forth standards for capital defense attorneys, which
      led an interdisciplinary team to produce the "Supplementary Guidelines for the
      Mitigation Function of Defense Teams in Death Penalty Cases" to promote the
      exceptional competence and diligence required when the consequence is life or
      death. This article summarizes the "Supplementary Guidelines," with implications 
      for social work practice--that is, professional responsibility, competence,
      interviewing skill, knowledge of behavioral and mental impairment, records
      review, life history compilation, data interpretation, witness support,
      law-related knowledge, and testimony. The social work, which is scrutinized in a 
      court of law, requires cultural competence, diverse oral and written
      communication skills, diligence, and the highest ethical standards.
FAU - Andrews, Arlene Bowers
AU  - Andrews AB
AD  - College of Social Work, University of South Carolina, Columbia, SC 29208, USA.
      arlene.andrews@sc.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Soc Work
JT  - Social work
JID - 2984852R
SB  - IM
MH  - Capital Punishment/*legislation & jurisprudence
MH  - *Expert Testimony
MH  - Guidelines as Topic
MH  - Humans
MH  - *Social Work
MH  - United States
EDAT- 2012/10/09 06:00
MHDA- 2012/11/03 06:00
CRDT- 2012/10/09 06:00
PHST- 2012/10/09 06:00 [entrez]
PHST- 2012/10/09 06:00 [pubmed]
PHST- 2012/11/03 06:00 [medline]
AID - 10.1093/sw/sws033 [doi]
PST - ppublish
SO  - Soc Work. 2012 Apr;57(2):155-64. doi: 10.1093/sw/sws033.


PMID- 23038858
OWN - NLM
STAT- MEDLINE
DCOM- 20121023
LR  - 20211203
IS  - 0963-6625 (Print)
IS  - 0963-6625 (Linking)
VI  - 21
IP  - 4
DP  - 2012 May
TI  - Science, governance, and public participation: an analysis of decision making on 
      genetic modification in Aotearoa/New Zealand.
PG  - 447-64
AB  - The acceptance of public participation in science and technology governance in
      liberal democratic contexts is evident in the institutionalization of a variety
      of mechanisms for participation in recent decades. Yet questions remain about the
      extent to which institutions have actually transformed their policy practice to
      embrace democratic governance of techno-scientific decision making. A critical
      discourse analysis of the response to public participation by the Environmental
      Risk ManagementAuthority (ERMA), the key decision-making body on genetic
      modification in Aotearoa/New Zealand, in a specific case demonstrates that ERMA
      systematically marginalized concerns raised by the public about risk management, 
      ethics, and ecological, economic, and cultural issues in order to give primacy to
      a positivist, technological worldview. Such delegitimization of public
      perspectives pre-empts the possibility of the democratic governance of science.
FAU - Kurian, Priya
AU  - Kurian P
AD  - Political Science and Public Policy, School of Social Sciences,The University of 
      Waikato, Hamilton 3240, New Zealand pkurian@waikato.ac.nz
FAU - Wright, Jeanette
AU  - Wright J
LA  - eng
PT  - Journal Article
PL  - England
TA  - Public Underst Sci
JT  - Public understanding of science (Bristol, England)
JID - 9306503
MH  - *Agriculture
MH  - Animal Welfare
MH  - *Community Participation
MH  - Decision Making
MH  - *Genetic Engineering/legislation & jurisprudence/psychology
MH  - Humans
MH  - Native Hawaiian or Other Pacific Islander/psychology
MH  - New Zealand
MH  - *Policy Making
MH  - Politics
MH  - Risk Management
EDAT- 2012/10/09 06:00
MHDA- 2012/10/24 06:00
CRDT- 2012/10/09 06:00
PHST- 2012/10/09 06:00 [entrez]
PHST- 2012/10/09 06:00 [pubmed]
PHST- 2012/10/24 06:00 [medline]
AID - 10.1177/0963662510382362 [doi]
PST - ppublish
SO  - Public Underst Sci. 2012 May;21(4):447-64. doi: 10.1177/0963662510382362.


PMID- 23038802
OWN - NLM
STAT- MEDLINE
DCOM- 20140113
LR  - 20181202
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 8
DP  - 2013 Aug
TI  - Response to the commentaries of Melissa S Anderson and Murray J Dyck.
PG  - 515-6
LID - 10.1136/medethics-2012-101016 [doi]
AB  - Anderson and Dyck claim that the current trend of almost exclusively using
      citation-based evaluative metrics to assess the research output of scholars is
      unsound. I agree with them in this, but I feel that, for practical reasons, this 
      system will not disappear in the near future, so we must concentrate on making it
      fairer. Both commentators doubt whether numerically expressing each contributor's
      relative contribution is feasible. I admit that an important precondition for
      this task is the possibility of an informed, democratic debate among equals about
      the relative contribution of each contributor to the article. Mechanisms should
      be established to protect vulnerable researchers in the academic field in the
      same way as safeguards exist today to protect vulnerable research participants.
      Theoretically, however, I think that the fair allocation of authorship credit is 
      possible, and much of this task is already being performed routinely when
      contributors determine the order of their names in the byline, being well aware
      of the widespread assumption that this order mostly mirrors the order of their
      relative contributions. All they would have to do as an additional task is to
      express this order in numbers. If they cannot reach a consensus, they could
      always choose not to express their relative contribution in numbers, in which
      case the presumption would be that they contributed equally. My proposal could,
      at best, make the system fairer and, at worst, not reduce the options that
      evaluators already have.
FAU - Kovacs, Jozsef
AU  - Kovacs J
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20121004
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
CON - J Med Ethics. 2013 Aug;39(8):509-12. PMID: 22865926
CON - J Med Ethics. 2013 Aug;39(8):514. PMID: 22956740
CON - J Med Ethics. 2013 Aug;39(8):513. PMID: 22993172
MH  - Authorship/*standards
MH  - *Bibliometrics
MH  - Humans
MH  - Publishing/*ethics
MH  - Research Personnel/*ethics
MH  - *Research Report
OTO - NOTNLM
OT  - Publication Ethics
OT  - Research Ethics
OT  - Scientific Research
EDAT- 2012/10/06 06:00
MHDA- 2014/01/15 06:00
CRDT- 2012/10/06 06:00
PHST- 2012/10/06 06:00 [entrez]
PHST- 2012/10/06 06:00 [pubmed]
PHST- 2014/01/15 06:00 [medline]
AID - medethics-2012-101016 [pii]
AID - 10.1136/medethics-2012-101016 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Aug;39(8):515-6. doi: 10.1136/medethics-2012-101016. Epub 2012
      Oct 4.


PMID- 23038799
OWN - NLM
STAT- MEDLINE
DCOM- 20130325
LR  - 20130121
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 2
DP  - 2013 Feb
TI  - Photographing human subjects in biomedical disciplines: an Islamic perspective.
PG  - 84-8
LID - 10.1136/medethics-2012-100794 [doi]
AB  - Visual recording of human subjects is commonly used in biomedical disciplines for
      clinical, research, legal, academic and even personal purposes. Guidelines on
      practice standards of biomedical recording have been issued by certain health
      authorities, associations and journals, but none of the literature discusses this
      from an Islamic perspective. This article begins with a discussion on the general
      rules associated with visual recording in Islam, followed by modesty issues in
      biomedical recording and issues of informed consent and confidentiality. In order
      to be deemed ethical from the Islamic perspective, all the aforementioned
      criteria must conform to, or not contradict, Islamic teaching.
FAU - Saidun, Salilah
AU  - Saidun S
AD  - Department of Science and Technology Studies, Faculty of Science, University of
      Malaya, Kuala Lumpur 50603, Malaysia. s_salilah@yahoo.com
LA  - eng
PT  - Journal Article
DEP - 20121004
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Biomedical Research/ethics
MH  - *Confidentiality/ethics
MH  - Education, Professional/standards
MH  - Ethics, Clinical
MH  - *Gender Identity
MH  - Health Personnel/education
MH  - *Human Body
MH  - Humans
MH  - *Informed Consent/ethics
MH  - *Islam
MH  - *Medical Chaperones
MH  - Patient Care/ethics
MH  - Photography/*ethics
MH  - Touch
EDAT- 2012/10/06 06:00
MHDA- 2013/03/26 06:00
CRDT- 2012/10/06 06:00
PHST- 2012/10/06 06:00 [entrez]
PHST- 2012/10/06 06:00 [pubmed]
PHST- 2013/03/26 06:00 [medline]
AID - medethics-2012-100794 [pii]
AID - 10.1136/medethics-2012-100794 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Feb;39(2):84-8. doi: 10.1136/medethics-2012-100794. Epub 2012 
      Oct 4.


PMID- 23037935
OWN - NLM
STAT- MEDLINE
DCOM- 20130722
LR  - 20220210
IS  - 1530-0366 (Electronic)
IS  - 1098-3600 (Linking)
VI  - 15
IP  - 2
DP  - 2013 Feb
TI  - Getting our priorities straight: a novel framework for stakeholder-informed
      prioritization of cancer genomics research.
PG  - 115-22
LID - 10.1038/gim.2012.103 [doi]
AB  - PURPOSE: Prioritization of translational research on genomic tests is critically 
      important given the rapid pace of innovation in genomics. The goal of this study 
      was to evaluate a stakeholder-informed priority-setting framework in cancer
      genomics. METHODS: An external stakeholder advisory group including
      patients/consumers, payers, clinicians, and test developers used a modified
      Delphi approach to prioritize six candidate cancer genomic technologies during a 
      1-day meeting. Nine qualitative priority-setting criteria were considered. We
      used a directed, qualitative content-analysis approach to investigate the themes 
      of the meeting discussion. RESULTS: Stakeholders primarily discussed six of the
      original nine criteria: clinical benefits, population health impacts, economic
      impacts, analytical and clinical validity, clinical trial implementation and
      feasibility, and market factors. Several new priority-setting criteria were
      identified from the workshop transcript, including "patient-reported outcomes,"
      "clinical trial ethics," and "trial recruitment." The new criteria were
      incorporated with prespecified criteria to develop a novel priority-setting
      framework. CONCLUSION: This study highlights key criteria that stakeholders can
      consider when prioritizing comparative effectiveness research for cancer genomic 
      applications. Applying an explicit priority-setting framework to inform
      investment in comparative effectiveness research can help to ensure that critical
      factors are weighed when deciding between many potential research questions and
      trial designs.
FAU - Esmail, Laura C
AU  - Esmail LC
AD  - Center for Medical Technology Policy, Baltimore, MD, USA. laura.esmail@gmail.com
FAU - Roth, Josh
AU  - Roth J
FAU - Rangarao, Sneha
AU  - Rangarao S
FAU - Carlson, Josh J
AU  - Carlson JJ
FAU - Thariani, Rahber
AU  - Thariani R
FAU - Ramsey, Scott D
AU  - Ramsey SD
FAU - Veenstra, David L
AU  - Veenstra DL
FAU - Deverka, Patricia
AU  - Deverka P
LA  - eng
GR  - RC2 CA148570/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, American Recovery and Reinvestment Act
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20121004
PL  - United States
TA  - Genet Med
JT  - Genetics in medicine : official journal of the American College of Medical
      Genetics
JID - 9815831
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (DNA-Binding Proteins)
RN  - EC 2.7.10.1 (EGFR protein, human)
RN  - EC 2.7.10.1 (ErbB Receptors)
RN  - EC 2.7.11.1 (BRAF protein, human)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins B-raf)
RN  - EC 3.1.- (ERCC1 protein, human)
RN  - EC 3.1.- (Endonucleases)
SB  - IM
MH  - Biomarkers, Tumor/genetics
MH  - Breast Neoplasms/diagnosis/genetics
MH  - Carcinoma, Non-Small-Cell Lung/diagnosis/genetics
MH  - Colorectal Neoplasms/diagnosis/genetics
MH  - Comparative Effectiveness Research/methods/standards
MH  - DNA-Binding Proteins/genetics
MH  - Endonucleases/genetics
MH  - ErbB Receptors/genetics
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Genetic Testing/methods/standards
MH  - Genomics/*methods/standards
MH  - Health Priorities
MH  - Humans
MH  - Lung Neoplasms/diagnosis/genetics
MH  - Mutation
MH  - Neoplasms/*diagnosis/*genetics
MH  - Proto-Oncogene Proteins B-raf/genetics
MH  - Translational Research, Biomedical/*methods/standards
PMC - PMC4479129
MID - NIHMS699846
EDAT- 2012/10/06 06:00
MHDA- 2013/07/23 06:00
CRDT- 2012/10/06 06:00
PHST- 2012/10/06 06:00 [entrez]
PHST- 2012/10/06 06:00 [pubmed]
PHST- 2013/07/23 06:00 [medline]
AID - S1098-3600(21)00906-0 [pii]
AID - 10.1038/gim.2012.103 [doi]
PST - ppublish
SO  - Genet Med. 2013 Feb;15(2):115-22. doi: 10.1038/gim.2012.103. Epub 2012 Oct 4.


PMID- 23037635
OWN - NLM
STAT- MEDLINE
DCOM- 20130827
LR  - 20171116
IS  - 1423-0003 (Electronic)
IS  - 0304-324X (Linking)
VI  - 59
IP  - 2
DP  - 2013
TI  - Strategies for engineered negligible senescence.
PG  - 183-9
LID - 10.1159/000342197 [doi]
AB  - In this viewpoint, we describe the strategies for engineered negligible
      senescence (SENS) concept--a simple and appealing model for the design of
      therapeutic interventions able to meaningfully and persistently reverse the
      deleterious effects of aging. We go on to outline how current or foreseeable
      biotechnologies could feasibly be employed to repair every currently identified
      category of pathogenic damage that accumulates over a human lifespan. Then,
      briefly, we explain why this goal is not only ethically sound, but can in fact be
      considered to verge on an ethical obligation. Finally, we review recent progress 
      in some key areas of the SENS platform, including proof-of-concept research
      sponsored by the SENS Foundation, a charity based in California.
CI  - Copyright (c) 2012 S. Karger AG, Basel.
FAU - Zealley, Ben
AU  - Zealley B
AD  - SENS Foundation, Mountain View, CA 94041, USA.
FAU - de Grey, Aubrey D N J
AU  - de Grey AD
LA  - eng
PT  - Journal Article
DEP - 20121001
PL  - Switzerland
TA  - Gerontology
JT  - Gerontology
JID - 7601655
SB  - IM
CIN - Gerontology. 2013;59(2):190-2. PMID: 23037994
MH  - *Aging
MH  - Cell Death
MH  - Cell Proliferation
MH  - Cellular Senescence
MH  - Geriatrics/*methods
MH  - Humans
MH  - Models, Biological
MH  - Regenerative Medicine/*methods
EDAT- 2012/10/06 06:00
MHDA- 2013/08/28 06:00
CRDT- 2012/10/06 06:00
PHST- 2011/12/28 00:00 [received]
PHST- 2012/06/27 00:00 [accepted]
PHST- 2012/10/06 06:00 [entrez]
PHST- 2012/10/06 06:00 [pubmed]
PHST- 2013/08/28 06:00 [medline]
AID - 000342197 [pii]
AID - 10.1159/000342197 [doi]
PST - ppublish
SO  - Gerontology. 2013;59(2):183-9. doi: 10.1159/000342197. Epub 2012 Oct 1.


PMID- 23037187
OWN - NLM
STAT- MEDLINE
DCOM- 20160408
LR  - 20161021
IS  - 0351-3254 (Print)
IS  - 0351-3254 (Linking)
VI  - 33
IP  - 1
DP  - 2012
TI  - Neuroimaging and neuroethics: imaging the ethics in neuroscience.
PG  - 419-24
AB  - UNLABELLED: This paper outlines the topics that are on the intersection of
      neuroethics and neuroimaging domain. MATERIALS AND METHODS: An extensive search
      through Medline bibliographic database was performed for a period of 12 years
      (1997-2009), using a combination of 3 keywords ("ethics", "neuroethics",
      "neuroimaging"). The search returned 119 indexed articles, of which 102 were
      found relevant. The articles were classified in two main categories tackling
      ethical challenges in basic research (55 papers) and applied clinical research
      and practice (39 papers). RESULTS AND CONCLUSIONS: For each of the categories,
      the majority of articles came under one of the following topics--the neural basis
      of emotion, reasoning and personality (30 papers) and ethics of neuroimaging in
      disorders of consciousness (15 papers). The appointed topics stand at the very
      intersection of the neuroethics and neuroimaging domain, evidencing their strong 
      interdependent relationship. Furthermore, the number of topics and corresponding 
      articles has been steadily increasing over the years (minimal in 1997, maximal in
      2009). These data are in good acconcordance with other scientific findings. Also,
      they correspond to the period of progress in the investigated disciplines, giving
      rise to the fact that future advances in neuroethics are in strong correlation to
      the advances of neuroimaging technologies.
FAU - Gjoneska, B
AU  - Gjoneska B
AD  - Neuroinformatics Division, Department of Bioinformatics, Macedonian Academy of
      Sciences and Arts, Skopje, R. Macedonia.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Prilozi
JT  - Prilozi
JID - 101189513
SB  - IM
MH  - Ethics, Medical
MH  - Ethics, Research
MH  - Humans
MH  - Neuroimaging/*ethics
MH  - Neurosciences/*ethics
EDAT- 2012/10/06 06:00
MHDA- 2016/04/09 06:00
CRDT- 2012/10/06 06:00
PHST- 2012/10/06 06:00 [entrez]
PHST- 2012/10/06 06:00 [pubmed]
PHST- 2016/04/09 06:00 [medline]
PST - ppublish
SO  - Prilozi. 2012;33(1):419-24.


PMID- 23036642
OWN - NLM
STAT- MEDLINE
DCOM- 20150721
LR  - 20211021
IS  - 1478-6362 (Electronic)
IS  - 1478-6354 (Linking)
VI  - 14
IP  - 5
DP  - 2012 Oct 4
TI  - Impaired skeletal muscle microcirculation in systemic sclerosis.
PG  - R209
LID - 10.1186/ar4047 [doi]
AB  - INTRODUCTION: Muscle symptoms in systemic sclerosis (SSc) may originate from
      altered skeletal muscle microcirculation, which can be investigated by means of
      blood oxygenation level dependent (BOLD) magnetic resonance imaging (MRI).
      METHODS: After ethics committee approval and written consent, 11 consecutive SSc 
      patients (5 men, mean age 52.6 years, mean SSc disease duration 5.4 years) and 12
      healthy volunteers (4 men, mean age 45.1 years) were included. Subjects with
      peripheral arterial occlusive disease were excluded. BOLD MRI was performed on
      calf muscles during cuff-induced ischemia and reactive hyperemia, using a 3-T
      whole-body scanner (Verio, Siemens, Erlangen, Germany) and fat-suppressed
      single-short multi-echo echo planar imaging (EPI) with four different effective
      echo times. Muscle BOLD signal time courses were obtained for gastrocnemius and
      soleus muscles: minimal hemoglobin oxygen saturation (T2*min) and maximal T2*
      values (T2*max), time to T2* peak (TTP), and slopes of oxygen normalization after
      T2* peaking. RESULTS: The vast majority of SSc patients lacked skeletal muscle
      atrophy, weakness or serum creatine kinase elevation. Nevertheless, more intense 
      oxygen desaturation during ischemia was observed in calf muscles of SSc patients 
      (mean T2*min -15.0%), compared with controls (-9.1%, P = 0.02). SSc patients also
      had impaired oxygenation during hyperemia (median T2*max 9.2% vs. 20.1%,
      respectively, P = 0.007). The slope of muscle oxygen normalization was
      significantly less steep and prolonged (TTP) in SSc patients (P<0.001 for both). 
      Similar differences were found at a separate analysis of gastrocnemius and soleus
      muscles, with most pronounced impairment in the gastrocnemius. CONCLUSIONS: BOLD 
      MRI demonstrates a significant impairment of skeletal muscle microcirculation in 
      SSc.
FAU - Partovi, Sasan
AU  - Partovi S
FAU - Schulte, Anja-Carina
AU  - Schulte AC
FAU - Aschwanden, Markus
AU  - Aschwanden M
FAU - Staub, Daniel
AU  - Staub D
FAU - Benz, Daniela
AU  - Benz D
FAU - Imfeld, Stephan
AU  - Imfeld S
FAU - Jacobi, Bjorn
AU  - Jacobi B
FAU - Broz, Pavel
AU  - Broz P
FAU - Jager, Kurt A
AU  - Jager KA
FAU - Takes, Martin
AU  - Takes M
FAU - Huegli, Rolf W
AU  - Huegli RW
FAU - Bilecen, Deniz
AU  - Bilecen D
FAU - Walker, Ulrich A
AU  - Walker UA
LA  - eng
PT  - Journal Article
DEP - 20121004
PL  - England
TA  - Arthritis Res Ther
JT  - Arthritis research & therapy
JID - 101154438
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Hyperemia/pathology/physiopathology
MH  - Ischemia/pathology/physiopathology
MH  - Leg/blood supply
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Microcirculation/*physiology
MH  - Middle Aged
MH  - Muscle, Skeletal/*blood supply/*pathology
MH  - Oxygen/blood
MH  - Scleroderma, Systemic/pathology/*physiopathology
PMC - PMC3580521
EDAT- 2012/10/06 06:00
MHDA- 2015/07/22 06:00
CRDT- 2012/10/06 06:00
PHST- 2012/05/28 00:00 [received]
PHST- 2012/09/27 00:00 [accepted]
PHST- 2012/10/06 06:00 [entrez]
PHST- 2012/10/06 06:00 [pubmed]
PHST- 2015/07/22 06:00 [medline]
AID - ar4047 [pii]
AID - 10.1186/ar4047 [doi]
PST - epublish
SO  - Arthritis Res Ther. 2012 Oct 4;14(5):R209. doi: 10.1186/ar4047.


PMID- 23036252
OWN - NLM
STAT- MEDLINE
DCOM- 20121219
LR  - 20220309
IS  - 1557-8240 (Electronic)
IS  - 0031-3955 (Linking)
VI  - 59
IP  - 5
DP  - 2012 Oct
TI  - Ethical issues in neonatal and pediatric clinical trials.
PG  - 1205-20
LID - 10.1016/j.pcl.2012.07.007 [doi]
LID - S0031-3955(12)00118-6 [pii]
AB  - Children have been identified as uniquely vulnerable clinical research subjects
      since the early 1970s. This article reviews the historical underpinnings of this 
      designation, the current regulatory framework for pediatric and neonatal
      research, and common problems in pediatric research oversight. It also presents 3
      areas of pediatric and neonatal research (genomic screening, healthy children
      donating stem cells, and therapeutic hypothermia for neonates with
      hypoxic-ischemic encephalopathy) that highlight contemporary challenges in
      pediatric research ethics, including balancing risk and benefit, informed consent
      and assent, and clinical equipoise.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Laventhal, Naomi
AU  - Laventhal N
AD  - Division of Neonatal-Perinatal Medicine, Department of Pediatrics and
      Communicable Diseases, University of Michigan School of Medicine, 8-621 C&W Mott 
      Hospital, 1540 East Hospital Drive, SPC 4254, Ann Arbor, MI 48109-4254, USA.
      naomilav@med.umich.edu
FAU - Tarini, Beth A
AU  - Tarini BA
FAU - Lantos, John
AU  - Lantos J
LA  - eng
GR  - K23 HD057994/HD/NICHD NIH HHS/United States
GR  - UL1 RR033179/RR/NCRR NIH HHS/United States
GR  - UL1 TR000001/TR/NCATS NIH HHS/United States
GR  - K23HD057994/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20120826
PL  - United States
TA  - Pediatr Clin North Am
JT  - Pediatric clinics of North America
JID - 0401126
SB  - IM
MH  - Child
MH  - Clinical Trials as Topic/*ethics/standards
MH  - *Ethics, Medical
MH  - Federal Government
MH  - Guidelines as Topic
MH  - Humans
MH  - Infant, Newborn
MH  - Informed Consent
MH  - Pediatrics/*ethics
MH  - Risk Assessment
MH  - United States
PMC - PMC3465563
MID - NIHMS403542
EDAT- 2012/10/06 06:00
MHDA- 2012/12/20 06:00
CRDT- 2012/10/06 06:00
PHST- 2012/10/06 06:00 [entrez]
PHST- 2012/10/06 06:00 [pubmed]
PHST- 2012/12/20 06:00 [medline]
AID - S0031-3955(12)00118-6 [pii]
AID - 10.1016/j.pcl.2012.07.007 [doi]
PST - ppublish
SO  - Pediatr Clin North Am. 2012 Oct;59(5):1205-20. doi: 10.1016/j.pcl.2012.07.007.
      Epub 2012 Aug 26.


PMID- 23036064
OWN - NLM
STAT- MEDLINE
DCOM- 20131119
LR  - 20121005
IS  - 1091-3734 (Electronic)
IS  - 1091-3734 (Linking)
VI  - 17
IP  - 3
DP  - 2012 Jul 3
TI  - Ethics: creating a culture of ethical watchfulness.
PG  - 9
FAU - Merkle Sorrell, Jeanne
AU  - Merkle Sorrell J
AD  - Department of Nursing Research and Innovation at the Cleveland Clinic, Cleveland,
      OH, USA. jsorrell@gmu.edu
LA  - eng
PT  - Journal Article
DEP - 20120703
PL  - United States
TA  - Online J Issues Nurs
JT  - Online journal of issues in nursing
JID - 9806525
SB  - IM
MH  - Aged, 80 and over
MH  - Clinical Competence
MH  - Emergencies
MH  - *Ethics, Nursing
MH  - Female
MH  - Humans
MH  - Male
MH  - *Nurse's Role
MH  - Nursing Staff, Hospital/ethics
MH  - *Organizational Culture
MH  - *Patient Advocacy
MH  - *Quality of Health Care
MH  - United States
EDAT- 2012/10/06 06:00
MHDA- 2013/11/20 06:00
CRDT- 2012/10/06 06:00
PHST- 2012/10/06 06:00 [entrez]
PHST- 2012/10/06 06:00 [pubmed]
PHST- 2013/11/20 06:00 [medline]
AID - /Vol-17-2012/No3-Sept-2012/Ethics-Culture-of-Ethical-Watchfulnes.html [pii]
PST - epublish
SO  - Online J Issues Nurs. 2012 Jul 3;17(3):9.


PMID- 23036058
OWN - NLM
STAT- MEDLINE
DCOM- 20131119
LR  - 20191210
IS  - 1091-3734 (Electronic)
IS  - 1091-3734 (Linking)
VI  - 17
IP  - 3
DP  - 2012 Sep 30
TI  - Social media use in nursing education.
PG  - 2
AB  - As technological advances continue to expand connectivity and communication, the 
      number of patients and nurses engaging in social media increases. Nurses play a
      significant role in identification, interpretation, and transmission of knowledge
      and information within healthcare. Social media is a platform that can assist
      nursing faculty in helping students to gain greater understanding of and/or
      skills in professional communication; health policy; patient privacy and ethics; 
      and writing competencies. Although there are barriers to integration of social
      media within nursing education, there are quality resources available to assist
      faculty to integrate social media as a viable pedagogical method. This article
      discusses the background and significance of social media tools as pedagogy, and 
      provides a brief review of literature. To assist nurse educators who may be using
      or considering social media tools, the article offers selected examples of sound 
      and pedagogically functional use in course and program applications;
      consideration of privacy concerns and advantages and disadvantages; and tips for 
      success.
FAU - Schmitt, Terri L
AU  - Schmitt TL
AD  - The Christine E. Lynn College of Nursing at Florida Atlantic University, USA.
      Tschmitt2002@gmail.com
FAU - Sims-Giddens, Susan S
AU  - Sims-Giddens SS
FAU - Booth, Richard G
AU  - Booth RG
LA  - eng
PT  - Journal Article
DEP - 20120930
PL  - United States
TA  - Online J Issues Nurs
JT  - Online journal of issues in nursing
JID - 9806525
SB  - IM
MH  - Bibliographies as Topic
MH  - *Blogging
MH  - Curriculum
MH  - Education, Nursing/*methods
MH  - Education, Nursing, Graduate/methods
MH  - Humans
MH  - Nursing Informatics/education
MH  - *Social Media
MH  - Teaching/*methods
MH  - United States
EDAT- 2012/10/06 06:00
MHDA- 2013/11/20 06:00
CRDT- 2012/10/06 06:00
PHST- 2012/10/06 06:00 [entrez]
PHST- 2012/10/06 06:00 [pubmed]
PHST- 2013/11/20 06:00 [medline]
AID - Vol-17-2012/No3-Sept-2012/Social-Media-in-Nursing-Education.html [pii]
PST - epublish
SO  - Online J Issues Nurs. 2012 Sep 30;17(3):2.


PMID- 23035901
OWN - NLM
STAT- MEDLINE
DCOM- 20131031
LR  - 20130605
IS  - 1445-2197 (Electronic)
IS  - 1445-1433 (Linking)
VI  - 83
IP  - 6
DP  - 2013 Jun
TI  - Cost-effective framework for basic surgical skills training.
PG  - 472-6
LID - 10.1111/j.1445-2197.2012.06289.x [doi]
AB  - BACKGROUND: The importance of basic surgical skills is entirely agreed among
      surgical educators. However, restricted by ethical issues, finance etc, the basic
      surgical skills training is increasingly challenged. Increasing cost gives an
      impetus to the development of cost-effective training models to meet the
      trainees' acquisition of basic surgical skills. In this situation, a
      cost-effective training framework was formed in our department and introduced
      here. METHODS: Each five students were assigned to a 'training unit'. The
      training was implemented weekly for 18 weeks. The framework consisted of an
      early, a transitional, an integrative stage and a surgical skills competition.
      Corresponding training modules were selected and assembled scientifically at each
      stage. The modules comprised campus intranet databases, sponge benchtop,
      nonliving animal tissue, local dissection specimens and simulating reality
      operations. The training outcomes used direct observation of procedural skills as
      an assessment tool. The training data of 50 trainees who were randomly selected
      in each year from 2006 to 2011 year, were retrospectively analysed. RESULTS: An
      excellent and good rate of the surgical skills is from 82 to 88%, but there is no
      significant difference among 6 years (P > 0.05). The skills scores of the
      contestants are markedly higher than those of non-contestants (P < 0.05). The
      average training cost per trainee is about $21.85-34.08. CONCLUSION: The present 
      training framework is reliable, feasible, repeatable and cost-effective. The
      skills competition can promote to improve the surgical skills level of trainees.
CI  - (c) 2012 The Authors. ANZ Journal of Surgery (c) 2012 Royal Australasian College 
      of Surgeons.
FAU - Jiang, Deng-Jin
AU  - Jiang DJ
AD  - Department of Applied Surgical Anatomy and Operative Surgery, College of Basic
      Medical Science, Third Military Medical University, Chongqing, China.
      jwjun2003@yahoo.com.cn
FAU - Wen, Chan
AU  - Wen C
FAU - Yang, Ai-Jun
AU  - Yang AJ
FAU - Zhu, Zhi-Li
AU  - Zhu ZL
FAU - Lei, Yan
AU  - Lei Y
FAU - Lan, Yang-Jun
AU  - Lan YJ
FAU - Huang, Qing-Yuan
AU  - Huang QY
FAU - Hou, Xiao-Yu
AU  - Hou XY
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121004
PL  - Australia
TA  - ANZ J Surg
JT  - ANZ journal of surgery
JID - 101086634
SB  - IM
MH  - China
MH  - *Clinical Competence
MH  - Computer Simulation
MH  - Cost-Benefit Analysis
MH  - Education, Medical, Continuing/*economics
MH  - Educational Measurement/*economics
MH  - Female
MH  - Humans
MH  - *Internship and Residency
MH  - Male
MH  - Retrospective Studies
MH  - Specialties, Surgical/economics/*education
EDAT- 2012/10/06 06:00
MHDA- 2013/11/01 06:00
CRDT- 2012/10/06 06:00
PHST- 2012/08/26 00:00 [accepted]
PHST- 2012/10/06 06:00 [entrez]
PHST- 2012/10/06 06:00 [pubmed]
PHST- 2013/11/01 06:00 [medline]
AID - 10.1111/j.1445-2197.2012.06289.x [doi]
PST - ppublish
SO  - ANZ J Surg. 2013 Jun;83(6):472-6. doi: 10.1111/j.1445-2197.2012.06289.x. Epub
      2012 Oct 4.


PMID- 23035887
OWN - NLM
STAT- MEDLINE
DCOM- 20130522
LR  - 20211021
IS  - 1471-2296 (Electronic)
IS  - 1471-2296 (Linking)
VI  - 13
DP  - 2012 Oct 4
TI  - The disappearance of the "revolving door" patient in Scottish general practice:
      successful policies.
PG  - 95
LID - 10.1186/1471-2296-13-95 [doi]
AB  - BACKGROUND: We describe the health of "revolving door" patients in general
      practice in Scotland, estimate changes in their number over the timescale of the 
      study, and explore reasons for changes, particularly related to NHS and
      government policy. METHODS: A mixed methods predominantly qualitative study,
      using a grounded theory approach, set in Scottish general practice.
      Semi-structured interviews were conducted with professional key informants, 6
      Practitioner Services staff who administer the GP registration system and 6 GPs
      with managerial or clinical experience of working with "revolving door" patients.
      Descriptive statistical analysis and qualitative analysis of patient removal
      episodes linked with routine hospital admissions, outpatient appointments, drug
      misuse treatment episodes and deaths were carried out with cohorts of "revolving 
      door" patients identified from 1999 to 2005 in Scotland. RESULTS: A "revolving
      door" patient is removed 4 or more times from GP lists in 7 years. Patients had
      complex health issues including substance misuse, psychiatric and physical health
      problems and were at high risk of dying. There was a dramatic reduction in the
      number of "revolving door" patients during the course of the study. CONCLUSIONS: 
      "Revolving door" patients in general practice had significant health problems.
      Their numbers have reduced dramatically since 2004 and this probably resulted
      from improved drug treatment services, pressure from professional bodies to
      reduce patient removals and the positive ethical regulatory and financial climate
      of the 2004 GMS GP contract. This is a positive development for the NHS.
FAU - Williamson, Andrea E
AU  - Williamson AE
AD  - General Practice and Primary Care, College of MVLS, University of Glasgow,
      Glasgow, UK. andrea.williamson@glasgow.ac.uk
FAU - Johnson, Paul C D
AU  - Johnson PC
FAU - Mullen, Kenneth
AU  - Mullen K
FAU - Wilson, Philip
AU  - Wilson P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121004
PL  - England
TA  - BMC Fam Pract
JT  - BMC family practice
JID - 100967792
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Appointments and Schedules
MH  - Female
MH  - General Practice/*trends
MH  - Hospitalization/*statistics & numerical data/trends
MH  - Humans
MH  - Male
MH  - Mental Disorders/epidemiology
MH  - Middle Aged
MH  - Mortality
MH  - Patient Dropouts/psychology/*statistics & numerical data
MH  - *Physician-Patient Relations
MH  - Qualitative Research
MH  - Scotland
MH  - State Medicine
MH  - Substance-Related Disorders/*epidemiology
MH  - Young Adult
PMC - PMC3528483
EDAT- 2012/10/06 06:00
MHDA- 2013/05/23 06:00
CRDT- 2012/10/06 06:00
PHST- 2012/06/14 00:00 [received]
PHST- 2012/09/27 00:00 [accepted]
PHST- 2012/10/06 06:00 [entrez]
PHST- 2012/10/06 06:00 [pubmed]
PHST- 2013/05/23 06:00 [medline]
AID - 1471-2296-13-95 [pii]
AID - 10.1186/1471-2296-13-95 [doi]
PST - epublish
SO  - BMC Fam Pract. 2012 Oct 4;13:95. doi: 10.1186/1471-2296-13-95.


PMID- 23035845
OWN - NLM
STAT- MEDLINE
DCOM- 20150113
LR  - 20140604
IS  - 1445-2197 (Electronic)
IS  - 1445-1433 (Linking)
VI  - 84
IP  - 6
DP  - 2014 Jun
TI  - Nuclear reprogramming and induced pluripotent stem cells: a review for surgeons.
PG  - E1-11
LID - 10.1111/j.1445-2197.2012.06282.x [doi]
AB  - Induced pluripotent stem cells (iPSCs) are generated from somatic cells by the
      exogenous expression of defined transcription factors. iPSCs share the defining
      features of embryonic stem cells (ESCs) in that they are able to self-renew
      indefinitely and maintain the potential to develop into all cell types of the
      body. These cells have key advantages over ESCs in that they are autologous to
      the donor cells and can be generated from individuals at any age. iPSCs also
      circumvent ethical and political issues surrounding the destruction of embryos
      that is necessary in the isolation of ESCs. This review briefly describes the
      advent of iPSC technology and the concepts of nuclear reprogramming, and
      discusses the potential application of this powerful biological tool in both
      surgical research and regenerative medicine.
CI  - (c) 2012 The Authors. ANZ Journal of Surgery (c) 2012 Royal Australasian College 
      of Surgeons.
FAU - Qi, Sara D
AU  - Qi SD
AD  - Department of Surgery, University of Melbourne, St. Vincent's Hospital,
      Melbourne, Victoria, Australia.
FAU - Smith, Paul D
AU  - Smith PD
FAU - Choong, Peter F
AU  - Choong PF
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121004
PL  - Australia
TA  - ANZ J Surg
JT  - ANZ journal of surgery
JID - 101086634
SB  - IM
MH  - Cellular Reprogramming/*physiology
MH  - Embryonic Stem Cells/*cytology
MH  - Female
MH  - Forecasting
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*cytology/*transplantation
MH  - Male
MH  - Quality Improvement
MH  - Stem Cell Transplantation/methods
MH  - Surgeons
OTO - NOTNLM
OT  - induced pluripotent stem cell
OT  - nuclear reprogramming
OT  - regenerative medicine
OT  - stem cell
EDAT- 2012/10/06 06:00
MHDA- 2015/01/15 06:00
CRDT- 2012/10/06 06:00
PHST- 2012/08/27 00:00 [accepted]
PHST- 2012/10/06 06:00 [entrez]
PHST- 2012/10/06 06:00 [pubmed]
PHST- 2015/01/15 06:00 [medline]
AID - 10.1111/j.1445-2197.2012.06282.x [doi]
PST - ppublish
SO  - ANZ J Surg. 2014 Jun;84(6):E1-11. doi: 10.1111/j.1445-2197.2012.06282.x. Epub
      2012 Oct 4.


PMID- 23035654
OWN - NLM
STAT- MEDLINE
DCOM- 20130523
LR  - 20160511
IS  - 2152-4998 (Electronic)
IS  - 2152-4971 (Linking)
VI  - 14
IP  - 6
DP  - 2012 Dec
TI  - Induced pluripotent stem cells: progress and future perspectives in the stem cell
      world.
PG  - 459-70
LID - 10.1089/cell.2012.0039 [doi]
AB  - Pluripotent stem cells (PSCs) have the potential to differentiate into many cell 
      types and therefore can be a valuable source for cell therapy. Embryonic stem
      cells (ESCs), which are derived from the inner cell mass (ICM) of the blastocyst,
      are representative of PSCs. However, use of these cells has some limitations,
      especially ethical restrictions and immune response. As a result, researchers
      have been looking for other cell sources or strategies to overcome these
      limitations. One kind of cellular reprogramming is the process of guiding mature 
      cells into a state of gene expression similar to PSCs. It has been demonstrated
      that somatic cells can be reprogrammed by various methods, including somatic cell
      nuclear transfer (SCNT) and cell fusion with ESCs or treatment with their
      extracts. This implies that some factors in oocytes and ESCs are able to initiate
      the reprogramming process. Accordingly, induced pluripotent stem cells (iPSCs)
      have been derived from somatic cells by ectopic expression of some transcription 
      factors. This discovery has resulted in raising several important questions about
      the mechanisms by which these factors influence the reprogramming and epigenetic 
      status of the cells. iPSCs hold great promise for regenerative medicine,
      developmental biology, and drug discovery because they circumvent problems
      associated with both ethical issues and immunological rejection. Here we review
      the experiments involved in the discovery of iPSCs, important factors in their
      reprogramming, and their future perspectives in cell therapy.
FAU - Rezanejad, Habib
AU  - Rezanejad H
AD  - Department of Biology, Faculty of Science, Ferdowsi University of Mashhad,
      Mashhad, Iran.
FAU - Matin, Maryam M
AU  - Matin MM
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121004
PL  - United States
TA  - Cell Reprogram
JT  - Cellular reprogramming
JID - 101528176
SB  - IM
MH  - Animals
MH  - *Cell Differentiation
MH  - Cell Fusion/methods
MH  - Cell- and Tissue-Based Therapy/methods/trends
MH  - Drug Discovery/methods/trends
MH  - Embryonic Stem Cells/cytology/metabolism/transplantation
MH  - Humans
MH  - *Induced Pluripotent Stem Cells/cytology/metabolism/transplantation
MH  - Nuclear Transfer Techniques
MH  - Regenerative Medicine/methods/trends
EDAT- 2012/10/06 06:00
MHDA- 2013/05/25 06:00
CRDT- 2012/10/06 06:00
PHST- 2012/10/06 06:00 [entrez]
PHST- 2012/10/06 06:00 [pubmed]
PHST- 2013/05/25 06:00 [medline]
AID - 10.1089/cell.2012.0039 [doi]
PST - ppublish
SO  - Cell Reprogram. 2012 Dec;14(6):459-70. doi: 10.1089/cell.2012.0039. Epub 2012 Oct
      4.


PMID- 23035396
OWN - NLM
STAT- MEDLINE
DCOM- 20121101
LR  - 20191112
IS  - 0394-7394 (Print)
IS  - 0394-7394 (Linking)
VI  - 27
IP  - 1
DP  - 2012
TI  - [Jean-Jacques Rosseau the vitalist. The moralization of medical hygiene between
      diet and ethical food].
PG  - 81-109
AB  - The historiographical prejudice that sees in Jean-Jacques Rousseau an implacable 
      opponent of scientific knowledge has long prevented an objective evaluation of
      the important influence that medical thought exerted over his philosophy. The aim
      of this paper is to show not only Rousseau's familiarity with the most important 
      expressions of eighteenth-century medical literature, but also his willingness to
      incorporate some medical suggestions in his philosophical and literary
      production. In the first part of this article, I try to show how Rousseau's
      sensibility theory presupposes precise medical ideals, related to Montpellier
      School of vitalism. In the second part, I stress how Rousseau's philosophy of
      alimentation (which has clear anthropological and political implications) can be 
      regarded as a genuine application of an ambition typical of vitalism: to use
      medical hygiene, also and above all, for moral purpose.
FAU - Menin, Marco
AU  - Menin M
AD  - Universita di Torino, Italy. Marco_Menin@libero.it
LA  - fre
PT  - Biography
PT  - English Abstract
PT  - Historical Article
PT  - Journal Article
TT  - Jean-Jacques Rousseau vitaliste: la moralisation de l'hygiene medicale entre
      regime dietetique et ethique alimentaire.
PL  - Netherlands
TA  - Nuncius
JT  - Nuncius
JID - 8807530
MH  - *Diet
MH  - Ethics, Medical/*history
MH  - *Food
MH  - France
MH  - History, 18th Century
MH  - Hygiene/*history
MH  - Literature, Modern/*history
MH  - *Morals
MH  - Vitalism/*history
PS  - Rosseau JJ
FPS - Rosseau, Jean-Jacques
EDAT- 2012/10/06 06:00
MHDA- 2012/11/02 06:00
CRDT- 2012/10/06 06:00
PHST- 2012/10/06 06:00 [entrez]
PHST- 2012/10/06 06:00 [pubmed]
PHST- 2012/11/02 06:00 [medline]
AID - 10.1163/182539112x636328 [doi]
PST - ppublish
SO  - Nuncius. 2012;27(1):81-109. doi: 10.1163/182539112x636328.


PMID- 23035387
OWN - NLM
STAT- MEDLINE
DCOM- 20121023
LR  - 20170214
IS  - 0306-3127 (Print)
IS  - 0306-3127 (Linking)
VI  - 42
IP  - 3
DP  - 2012 Jun
TI  - The human capacity to reflect and decide: bioethics and the reconfiguration of
      the research subject in the British biomedical sciences.
PG  - 348-68
AB  - This article examines how a fundamental element of the British bioethical
      assemblage - the literature on informed consent published between 1980 and 2000, 
      a period when bioethics became a powerful force in the UK--has influenced
      contemporary understandings of the research subject. Drawing on Foucault, the
      article argues that this corpus of texts has created a sphere of possibilities in
      which research subjects can imagine themselves as human beings who reflect and
      decide whether they want to participate in medical experimentation. In
      particular, it shows how the narratives found in these texts portray
      relationships between researchers and their human subjects as 'paternalistic',
      and calls for their replacement by new, more ethical relationships characterized 
      by both 'dialogue' and 'respect' and articulated around subjects who can 'think
      and take decisions'. It also discusses the different strategies- using patient
      information sheets, a list of possible questions and invitations to take time to 
      reflect--which the bioethical literature has developed in order to realise these 
      new, ethical relationships. As the article suggests, these narratives and
      strategies provide researchers and research subjects with models and examples of 
      how to interact with each other that are very different from the ones that
      prevailed before the emergence of bioethics.
FAU - Reubi, David
AU  - Reubi D
AD  - School of Global Studies, University of Sussex, Brighton, UK.
      D.Reubi@sussex.ac.uk
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - Soc Stud Sci
JT  - Social studies of science
JID - 7506743
MH  - Bioethical Issues
MH  - Biomedical Research/*ethics
MH  - Decision Making
MH  - History, 20th Century
MH  - Humans
MH  - Informed Consent/*ethics/history
MH  - *Personal Autonomy
MH  - Research Subjects/*psychology
MH  - United Kingdom
EDAT- 2012/10/06 06:00
MHDA- 2012/10/24 06:00
CRDT- 2012/10/06 06:00
PHST- 2012/10/06 06:00 [entrez]
PHST- 2012/10/06 06:00 [pubmed]
PHST- 2012/10/24 06:00 [medline]
AID - 10.1177/0306312712439457 [doi]
PST - ppublish
SO  - Soc Stud Sci. 2012 Jun;42(3):348-68. doi: 10.1177/0306312712439457.


PMID- 23035053
OWN - NLM
STAT- MEDLINE
DCOM- 20130304
LR  - 20191210
IS  - 1471-6771 (Electronic)
IS  - 0007-0912 (Linking)
VI  - 110
IP  - 2
DP  - 2013 Feb
TI  - Does warm-up using mental practice improve crisis resource management
      performance? A simulation study.
PG  - 299-304
LID - 10.1093/bja/aes351 [doi]
AB  - BACKGROUND: Mental practice (MP) is defined as the 'symbolic rehearsal of a
      physical activity in the absence of any gross-muscular movements' and has been
      used in sport and music to enhance performance. In healthcare, MP has been
      demonstrated to improve technical skill performance of surgical residents.
      However, its effect on crisis resource management (CRM) skills has yet to be
      determined. We aimed to investigate the effect of warm-up with MP on CRM skill
      performance during a simulated crisis scenario. METHODS: Following ethics board
      approval, 40 anaesthesia residents were randomized. The intervention group
      performed 20 min of MP of a script based on CRM principles. The control group
      received a 20 min didactic teaching session on an unrelated topic. Each subject
      then managed a simulated cardiac arrest. Two CRM experts rated the video
      recordings of each performance using the previously validated Ottawa GRS. The
      time to start chest compressions, administer epinephrine, and give blood was
      recorded. RESULTS: There was no significant difference between the intervention
      and control groups: total Ottawa GRS score was 24.50 (18.63-28.88 [6.50-34.50])
      (median (inter-quartile range [range]) vs 20.50 (13.00-29.13 [6.50-34.50])
      (P=0.53); the time to start chest compressions 146.0 s (138.0-231.0
      [115.0-323.0]) vs 162.5 s (138.0-231.0 [100.0-460.0]) (P=0.27), the time to
      epinephrine administration 163.0 s (151.0-187.0 [111.0-337.0]) vs 187.0 s
      (164.0-244.0 [115.0-310.0]) (P=0.09), and the time to blood administration 220.5 
      s (130.8-309.0 [92.0-485.0]) vs 252.5 (174.5-398.8 [65.0-527.0]) (P=0.48).
      CONCLUSION: Unlike technical skills, warm-up with MP does not seem to improve CRM
      skills in simulated crisis scenarios.
FAU - Hayter, M A
AU  - Hayter MA
AD  - Department of Anesthesiology and the Li Ka Shing Knowledge Institute, Allan
      Waters Family Simulation Center, St. Michael's Hospital, University of Toronto,
      Toronto, ON, Canada. megan.hayter@utoronto.ca
FAU - Bould, M D
AU  - Bould MD
FAU - Afsari, M
AU  - Afsari M
FAU - Riem, N
AU  - Riem N
FAU - Chiu, M
AU  - Chiu M
FAU - Boet, S
AU  - Boet S
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20121003
PL  - England
TA  - Br J Anaesth
JT  - British journal of anaesthesia
JID - 0372541
RN  - 0 (Vasoconstrictor Agents)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
CIN - Br J Anaesth. 2013 Feb;110(2):169-72. PMID: 23319667
MH  - Adult
MH  - Anesthesiology/education
MH  - Blood Transfusion
MH  - Cardiopulmonary Resuscitation/education
MH  - Case Management
MH  - Computer Simulation
MH  - *Crisis Intervention
MH  - Electric Countershock
MH  - Endpoint Determination
MH  - Epinephrine/therapeutic use
MH  - Female
MH  - Heart Arrest/etiology/therapy
MH  - Humans
MH  - Internship and Residency
MH  - Male
MH  - Manikins
MH  - Monitoring, Intraoperative
MH  - *Practice, Psychological
MH  - Sample Size
MH  - Shock, Hemorrhagic/complications/therapy
MH  - Vasoconstrictor Agents/therapeutic use
EDAT- 2012/10/05 06:00
MHDA- 2013/03/05 06:00
CRDT- 2012/10/05 06:00
PHST- 2012/10/05 06:00 [entrez]
PHST- 2012/10/05 06:00 [pubmed]
PHST- 2013/03/05 06:00 [medline]
AID - S0007-0912(17)32816-7 [pii]
AID - 10.1093/bja/aes351 [doi]
PST - ppublish
SO  - Br J Anaesth. 2013 Feb;110(2):299-304. doi: 10.1093/bja/aes351. Epub 2012 Oct 3.


PMID- 23035016
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121005
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 5
DP  - 2012
TI  - Discrepancy in patient-rated and oncologist-rated performance status on
      depression and anxiety in cancer: a prospective study protocol.
LID - 10.1136/bmjopen-2012-001799 [doi]
LID - e001799 [pii]
AB  - OBJECTIVE: Psychological distress is common in patients with cancer. We need a
      rapid means of screening for and identifying depression and anxiety in patients
      with cancer. The present study evaluates the potential of the Eastern Cooperative
      Oncology Group (ECOG) performance status (PS) scoring as a brief screening tool
      to assess psychological distress in routine cancer care. The ECOG PS is widely
      used by oncologists and the WHO, as a standardised measure to assess general
      well-being in patients with cancer and quality of life in cancer trials. We
      examine the discrepancy between patient-rated and oncologist-rated PS scores on
      the ECOG in a comparative assessment against the Hospital Anxiety and Depression 
      Scale (HADS). METHODS AND DESIGN: This is a prospective evaluation of
      approximately 500 ambulatory adult cancer patients from a large academic medical 
      centre. Participants will be asked to assess their own ECOG PS on a scale of 0-4,
      which will be compared to ECOG PS as rated by their oncologists. Higher ECOG PS
      scores indicate poorer daily functioning. Both patient-rated and oncologist-rated
      ECOG PS and their absolute differences will be tested for predictive and
      concurrent validity against the HADS. A HADS cut-off >/=15 will be used. Ethics
      approval for this study has been secured from the institutional ethics board.
      Outcomes are re-evaluated at 4-week to 6-week and 1-year follow-up. CONCLUSION:
      This study holds practical significance for rapid screening of psychological
      distress in the cancer clinic with the use of the ECOG PS scoring. Given the high
      prevalence of anxiety and depression in patients with cancer, screening is
      important to increase its recognition, which will, in turn, help to direct
      referrals and deliver appropriate intervention. This study also generates greater
      insight into the association between psychosomatic complaints and psychological
      distress. TRIAL REGISTRATION NUMBER: MEC 896.52.
FAU - Mei Hsien, Caryn Chan
AU  - Mei Hsien CC
AD  - Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
FAU - Wan Azman, Wan Azmad
AU  - Wan Azman WA
FAU - Md Yusof, Mastura
AU  - Md Yusof M
FAU - Ho, Gwo Fuang
AU  - Ho GF
FAU - Krupat, Edward
AU  - Krupat E
LA  - eng
PT  - Journal Article
DEP - 20121003
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
EIN - BMJ Open. 2012 Nov 05;2(6):null. PMID: 23129574
PMC - PMC3488734
EDAT- 2012/10/05 06:00
MHDA- 2012/10/05 06:01
CRDT- 2012/10/05 06:00
PHST- 2012/10/05 06:00 [entrez]
PHST- 2012/10/05 06:00 [pubmed]
PHST- 2012/10/05 06:01 [medline]
AID - bmjopen-2012-001799 [pii]
AID - 10.1136/bmjopen-2012-001799 [doi]
PST - epublish
SO  - BMJ Open. 2012 Oct 3;2(5). pii: bmjopen-2012-001799. doi:
      10.1136/bmjopen-2012-001799. Print 2012.


PMID- 23035015
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121005
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 5
DP  - 2012
TI  - Does prognosis and socioeconomic status impact on trust in physicians? Interviews
      with patients with coronary disease in South Australia.
LID - 10.1136/bmjopen-2012-001389 [doi]
LID - e001389 [pii]
AB  - OBJECTIVES: There is concern across a range of healthcare settings worldwide that
      trust in physicians is declining. Decreased trust may lead to lesser tolerance of
      prognosis uncertainty and an increased demand for tests, referrals and second
      opinions. Literature suggests that there has been a recent cultural shift towards
      decreased trust in, and increased questioning of, medical advice. We investigated
      the impact of varying prognosis and socioeconomic status (SES) on trust in
      physicians, and patient questioning of medical advice. DESIGN: Semistructured,
      audio-recorded transcribed interviews were conducted. The interview schedule was 
      developed with reference to the Health Belief Model. Interviews were conducted
      between October 2008 and September 2009. SETTING: Participants were recruited via
      general practitioner clinics and hospital cardiac rehabilitation programmes.
      PARTICIPANTS: Participants consisted of patients either receiving preventive
      treatment or active treatment for established cardiovascular disease. OUTCOME
      MEASURES: A coding structure was developed based on the aim of the research, to
      investigate the impact of varying prognosis and SES on trust in physicians.
      RESULTS: Older participants are more likely than their younger counterparts to be
      unquestioning of medical advice. Higher SES participants are more likely to
      question medical advice than lower SES participants. Also, unlike primary
      prevention participants, established pathology increased participants' trust, or 
      decreased questioning behaviour. Participants who perceived themselves at risk of
      a poor or uncertain outcome were unlikely to doubt medical advice. CONCLUSIONS:
      Blind trust in physicians remains strong in older participants, participants who 
      perceive their prognosis to be uncertain and a proportion of lower SES
      participants. This is important for practitioners in terms of patient agency and 
      points to the importance of moral and ethical practice. However, physicians also 
      need to be aware that there are a growing proportion of patients for whom trust
      needs to be developed, and cannot be assumed.
FAU - Meyer, Samantha B
AU  - Meyer SB
AD  - Discipline of Public Health, Flinders University, Adelaide, South Australia,
      Australia.
FAU - Ward, Paul R
AU  - Ward PR
FAU - Jiwa, Moyez
AU  - Jiwa M
LA  - eng
PT  - Journal Article
DEP - 20121003
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3488703
EDAT- 2012/10/05 06:00
MHDA- 2012/10/05 06:01
CRDT- 2012/10/05 06:00
PHST- 2012/10/05 06:00 [entrez]
PHST- 2012/10/05 06:00 [pubmed]
PHST- 2012/10/05 06:01 [medline]
AID - bmjopen-2012-001389 [pii]
AID - 10.1136/bmjopen-2012-001389 [doi]
PST - epublish
SO  - BMJ Open. 2012 Oct 3;2(5). pii: bmjopen-2012-001389. doi:
      10.1136/bmjopen-2012-001389. Print 2012.


PMID- 23034796
OWN - NLM
STAT- MEDLINE
DCOM- 20130305
LR  - 20151119
IS  - 1600-0455 (Electronic)
IS  - 0284-1851 (Linking)
VI  - 53
IP  - 10
DP  - 2012 Dec 1
TI  - 64-slice coronary computed tomography angiography using low tube voltage of 80 kV
      in subjects with normal body mass indices: comparative study using 120 kV.
PG  - 1099-106
LID - 10.1258/ar.2012.110573 [doi]
AB  - BACKGROUND: The radiation dose of coronary computed tomography (CT) angiography
      (CCTA) is generally higher than that of CT scans of other parts of the body, and 
      there is concern that the high radiation dose may result in increased cancer
      risk. Although various techniques have recently been introduced to lower the
      radiation dose of CCTA, there has been no direct comparison between protocols
      with 80 and 120 kV. PURPOSE: To assess the image quality and radiation dose of
      80-kV electrocardiography (ECG)-gated CCTA in subjects with a normal body mass
      index (BMI), compared to 120-kV ECG-gated CCTA. MATERIAL AND METHODS: This
      retrospective study was approved by our local ethics board, and the requirement
      of written informed consent was waived. We analyzed the CCTA images of 100
      subjects with BMIs <25 kg/m(2). Fifty subjects underwent 120-kV CCTA, and the
      other 50 subjects underwent 80-kV CCTA. Two blinded observers independently
      evaluated the subjective image quality of the coronary arteries. The objective
      image quality (signal-to-noise ratio [SNR] and contrast-to-noise ratio [CNR]) and
      radiation dose were also measured in each group. RESULTS: Although the objective 
      image quality of the 80-kV protocol images was significantly poorer than that of 
      120-kV protocol images (mean SNR, 14.9 +/- 4.7 vs. 19.8 +/- 4.4, P < 0.0001; mean
      CNR, 15.2 +/- 4.8 vs. 21.6 +/- 4.7, P < 0.0001), there was no significant
      difference in the subjective image quality between the two groups (mean image
      score, 4.7 +/- 1.1 vs. 4.5 +/- 0.7 for radiologist 1, P = 0.273; 5.0 +/- 1.0 vs. 
      4.8 +/- 1.0 for radiologist 2, P = 0.197). The radiation dose was reduced by 70% 
      with the 80-kV protocol and by 88% with the 80-kV and ECG-based tube current
      modulation than with the 120-kV protocol (3.42 +/- 1.16 and 2.9 +/- 0.8 vs. 11.49
      +/- 3.62 mSv, P < 0.0001). CONCLUSION: The low tube voltage CCTA protocol using
      80 kV allows significant reduction of the radiation dose without impairing the
      subjective image quality in subjects with normal BMIs.
FAU - Jun, Bo Ram
AU  - Jun BR
AD  - Department of Radiology, Korea University Guro Hospital, Korea University College
      of Medicine, Seoul, Korea.
FAU - Yong, Hwan Seok
AU  - Yong HS
FAU - Kang, Eun-Young
AU  - Kang EY
FAU - Woo, Ok Hee
AU  - Woo OH
FAU - Choi, Eun Jung
AU  - Choi EJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20121003
PL  - England
TA  - Acta Radiol
JT  - Acta radiologica (Stockholm, Sweden : 1987)
JID - 8706123
RN  - 0 (Contrast Media)
RN  - 4419T9MX03 (Iohexol)
RN  - 712BAC33MZ (iopromide)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Body Mass Index
MH  - Cardiac-Gated Imaging Techniques/*methods
MH  - Contrast Media
MH  - Coronary Angiography/*methods
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Iohexol/analogs & derivatives
MH  - Male
MH  - Middle Aged
MH  - Observer Variation
MH  - Radiation Dosage
MH  - Radiographic Image Enhancement/methods
MH  - Radiographic Image Interpretation, Computer-Assisted/methods
MH  - Retrospective Studies
MH  - Signal-To-Noise Ratio
MH  - Tomography, X-Ray Computed/instrumentation/*methods
EDAT- 2012/10/05 06:00
MHDA- 2013/03/06 06:00
CRDT- 2012/10/05 06:00
PHST- 2012/10/05 06:00 [entrez]
PHST- 2012/10/05 06:00 [pubmed]
PHST- 2013/03/06 06:00 [medline]
AID - ar.2012.110573 [pii]
AID - 10.1258/ar.2012.110573 [doi]
PST - ppublish
SO  - Acta Radiol. 2012 Dec 1;53(10):1099-106. doi: 10.1258/ar.2012.110573. Epub 2012
      Oct 3.


PMID- 23034775
OWN - NLM
STAT- MEDLINE
DCOM- 20131203
LR  - 20161125
IS  - 1049-7323 (Print)
IS  - 1049-7323 (Linking)
VI  - 22
IP  - 12
DP  - 2012 Dec
TI  - Research ethics in accessing hospital staff and securing informed consent.
PG  - 1727-38
LID - 10.1177/1049732312460765 [doi]
AB  - Qualitative researchers cannot rely on research ethics to be a static practice.
      In this article we discuss how observation of guidelines for inquiry and
      international agreements on the dignity of health care research are not
      sufficient on their own to ensure that the challenges inherent in the everyday
      management of a project are regulated. We focus in particular on ethics in
      accessing participants and the construction of informed consent. During our
      study, important contrasts emerged between the ideal presented for the standard
      ethics review process and practical ethics. As a result, we focused on building
      open communication with the participants through rigorous project management. We 
      analyzed the data and wrote this article collaboratively to represent the
      empirical reality of a team of researchers aiming to take ethical challenges
      seriously while collecting data in three National Health Service Trusts in the
      United Kingdom.
FAU - Franklin, Paula
AU  - Franklin P
AD  - Durham University, Stockton-on-Tees, United Kingdom. p.franklin@dur.ac.uk
FAU - Rowland, Emma
AU  - Rowland E
FAU - Fox, Rebekah
AU  - Fox R
FAU - Nicolson, Paula
AU  - Nicolson P
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20121003
PL  - United States
TA  - Qual Health Res
JT  - Qualitative health research
JID - 9202144
MH  - Communication
MH  - *Ethics, Research
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Personnel, Hospital/*ethics
MH  - *Qualitative Research
MH  - United Kingdom
EDAT- 2012/10/05 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/10/05 06:00
PHST- 2012/10/05 06:00 [entrez]
PHST- 2012/10/05 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 1049732312460765 [pii]
AID - 10.1177/1049732312460765 [doi]
PST - ppublish
SO  - Qual Health Res. 2012 Dec;22(12):1727-38. doi: 10.1177/1049732312460765. Epub
      2012 Oct 3.


PMID- 23034401
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20161020
IS  - 1941-2479 (Electronic)
IS  - 1010-5395 (Linking)
VI  - 24
IP  - 5
DP  - 2012 Sep
TI  - Humanitarian responses and their ethical implications.
PG  - 856-9
LID - 10.1177/1010539512462504 [doi]
AB  - As the frequency and seriousness of natural disasters increase, humanitarian
      response gains interests. Disaster, as a threat to a society, exposes the
      weaknesses of that society and aids from agents other than that society are
      needed in the disaster situation. This nature of humanitarian response makes
      ethical consideration necessary, but as the context is different, ethical
      concerns and principles are also different from those of conventional medical
      ethics. Ethical justification is essential to humanitarian responses, and ethical
      standards and ideals should be considered during the humanitarian responses.
FAU - Lee, Ilhak
AU  - Lee I
AD  - Department of Medical Ethics and Law, College of Medicine, Yonsei University,
      Seongsanno, 250 Seodaemun-gu, Seoul, Korea. arete2@yuhs.ac
LA  - eng
PT  - Journal Article
DEP - 20121002
PL  - China
TA  - Asia Pac J Public Health
JT  - Asia-Pacific journal of public health
JID - 8708538
SB  - IM
MH  - *Altruism
MH  - Humans
MH  - Relief Work/*ethics
EDAT- 2012/10/05 06:00
MHDA- 2013/02/13 06:00
CRDT- 2012/10/05 06:00
PHST- 2012/10/05 06:00 [entrez]
PHST- 2012/10/05 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
AID - 1010539512462504 [pii]
AID - 10.1177/1010539512462504 [doi]
PST - ppublish
SO  - Asia Pac J Public Health. 2012 Sep;24(5):856-9. doi: 10.1177/1010539512462504.
      Epub 2012 Oct 2.


PMID- 23034204
OWN - NLM
STAT- MEDLINE
DCOM- 20121204
LR  - 20181023
IS  - 0256-9574 (Print)
VI  - 102
IP  - 10
DP  - 2012 Sep 5
TI  - Unforeseen ethical/legal complications with screening tests in the capitation
      model of medical aid schemes.
PG  - 787-9
LID - 10.7196/samj.5825 [doi]
AB  - In the South African health care system patients/consumers are divided into those
      who can afford private care and those who rely on state medical assistance. The
      system is under pressure to fund delivery of medical care to its beneficiaries.
      We consider the effects of different funding models on medicolegal liability of
      health professionals serving the private sector. Medical reasons should determine
      the service rendered. However, financial implications of services rendered and
      defensive practice of medicine also contribute to treatment received by a patient
      and its remuneration. Practitioners who commit to delivering a predetermined set 
      of services within a particular time for a predetermined 'lump sum' are only paid
      for the service specifically requested. Should disease be found other than those 
      contracted for, we argue that inaction with regard to that disease would be
      deemed to be negligent or unethical according to legal and ethical
      considerations.
FAU - Jansen, Rita-Marie
AU  - Jansen RM
AD  - Department of Private Law, University of the Free State, Bloemfontein, South
      Africa. jansenr@ufs.ac.za
FAU - Gouws, Chris
AU  - Gouws C
FAU - Verschoor, Teuns
AU  - Verschoor T
LA  - eng
PT  - Journal Article
DEP - 20120905
PL  - South Africa
TA  - S Afr Med J
JT  - South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
JID - 0404520
SB  - IM
MH  - *Capitation Fee/ethics/legislation & jurisprudence
MH  - *Ethics, Medical
MH  - Fee-for-Service Plans
MH  - Guidelines as Topic
MH  - Humans
MH  - *Liability, Legal
MH  - Ophthalmology/*ethics/*legislation & jurisprudence
MH  - South Africa
EDAT- 2012/10/05 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/10/05 06:00
PHST- 2012/03/13 00:00 [received]
PHST- 2012/06/04 00:00 [accepted]
PHST- 2012/10/05 06:00 [entrez]
PHST- 2012/10/05 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.7196/samj.5825 [doi]
PST - epublish
SO  - S Afr Med J. 2012 Sep 5;102(10):787-9. doi: 10.7196/samj.5825.


PMID- 23033632
OWN - NLM
STAT- MEDLINE
DCOM- 20121024
LR  - 20161125
IS  - 0954-7762 (Print)
IS  - 0954-7762 (Linking)
VI  - 108
IP  - 38
DP  - 2012 Sep 18-24
TI  - Ethical issues around continuous deep sedation without hydration.
PG  - 22-5
AB  - By reviewing the literature on the subject, this article examines whether
      continuous deep sedation without hydration--in the context of palliative care for
      patients with advanced cancer at the end of life--could be seen as a moral and
      clinical equivalent of so-called "slow euthanasia". It focuses on length of
      survival, fluid retention and thirst, and reviews the evidence and lack of it
      that supports or questions the practice of withholding parenteral fluids at the
      sedated and palliated end of life.
FAU - Beland, Paul
AU  - Beland P
AD  - St Barnabas Lincolnshire Hospice.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Times
JT  - Nursing times
JID - 0423236
MH  - *Deep Sedation
MH  - *Ethics
MH  - *Fluid Therapy
MH  - Humans
MH  - United Kingdom
EDAT- 2012/10/05 06:00
MHDA- 2012/10/25 06:00
CRDT- 2012/10/05 06:00
PHST- 2012/10/05 06:00 [entrez]
PHST- 2012/10/05 06:00 [pubmed]
PHST- 2012/10/25 06:00 [medline]
PST - ppublish
SO  - Nurs Times. 2012 Sep 18-24;108(38):22-5.


PMID- 23033499
OWN - NLM
STAT- MEDLINE
DCOM- 20130211
LR  - 20220409
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 265
IP  - 3
DP  - 2012 Dec
TI  - Comparison of digital screening mammography and screen-film mammography in the
      early detection of clinically relevant cancers: a multicenter study.
PG  - 707-14
LID - 10.1148/radiol.12111461 [doi]
AB  - PURPOSE: To compare screen-film mammography with digital mammography in a breast 
      cancer screening program, with a focus on the clinical relevance of detected
      cancers. MATERIALS AND METHODS: The study was approved by the regional medical
      ethics review board. Informed consent was not required. Before the nationwide
      transition to digital mammography in the Dutch biennial screening program, the
      performance of digital mammography was studied in three screening regions. For
      initial screening examinations, mediolateral oblique and craniocaudal views were 
      obtained of each breast. In subsequent examinations, the mediolateral oblique
      view was standard. A craniocaudal view was added if indicated. Screening outcomes
      obtained with screen-film mammography and digital mammography, including
      radiologic and pathologic characteristics, were compared for initial and
      subsequent examinations. RESULTS: A total of 1,198,493 screening examinations
      were performed between 2003 and 2007. Recall was indicated in 18 896 cases
      (screen-film mammography: 2.6% at initial examinations, 1.3% at subsequent
      examinations; digital mammography: 4.4% at initial examinations, 2.1% at
      subsequent examinations; P < .001 for both). Breast cancer was diagnosed in 6410 
      women (detection rate per 1000 women with screen-film mammography: 5.6 at initial
      examinations, 5.2 at subsequent examinations; detection rate per 1000 women with 
      digital mammography: 6.8 at initial examinations, 6.1 at subsequent examinations;
      P = .02 and P < .001, respectively). Digital mammography depicted significantly
      more ductal carcinoma in situ (DCIS) lesions, irrespective of screening round.
      Invasive carcinoma was detected significantly more often in subsequent
      examinations, particularly when associated with microcalcifications (P = .047).
      The distribution of the histopathologic differentiation grades for DCIS and
      invasive carcinoma were similar with both modalities. However, with digital
      mammography more high-grade DCIS lesions were detected at subsequent examinations
      (P = .013). CONCLUSION: In a population-based breast screening program, the
      performance of digital mammography in the detection of DCIS and invasive
      carcinoma was substantially better than that of screen-film mammography. There is
      no sign of an increase in detection of low-grade DCIS lesions-indicative of
      possible overdiagnosis-with digital breast cancer screening. Rather, digital
      mammography appears to add to the detection of high-grade DCIS.
CI  - (c) RSNA, 2012.
FAU - Bluekens, Adriana M J
AU  - Bluekens AM
AD  - National Expert and Training Centre for Breast Cancer Screening, PO Box 6873,
      6503 GJ Nijmegen, the Netherlands. a.bluekens@lrcb.umcn.nl
FAU - Holland, Roland
AU  - Holland R
FAU - Karssemeijer, Nico
AU  - Karssemeijer N
FAU - Broeders, Mireille J M
AU  - Broeders MJ
FAU - den Heeten, Gerard J
AU  - den Heeten GJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
DEP - 20121002
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Breast Neoplasms/*diagnostic imaging/epidemiology
MH  - Chi-Square Distribution
MH  - Early Diagnosis
MH  - Female
MH  - Humans
MH  - Mammography/*methods
MH  - *Mass Screening
MH  - Middle Aged
MH  - Netherlands/epidemiology
MH  - Radiographic Image Enhancement
MH  - Radiographic Image Interpretation, Computer-Assisted
MH  - X-Ray Intensifying Screens
EDAT- 2012/10/04 06:00
MHDA- 2013/02/12 06:00
CRDT- 2012/10/04 06:00
PHST- 2012/10/04 06:00 [entrez]
PHST- 2012/10/04 06:00 [pubmed]
PHST- 2013/02/12 06:00 [medline]
AID - radiol.12111461 [pii]
AID - 10.1148/radiol.12111461 [doi]
PST - ppublish
SO  - Radiology. 2012 Dec;265(3):707-14. doi: 10.1148/radiol.12111461. Epub 2012 Oct 2.


PMID- 23033478
OWN - NLM
STAT- MEDLINE
DCOM- 20140113
LR  - 20181202
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 8
DP  - 2013 Aug
TI  - Rolling back the bureaucracies of ethics review.
PG  - 525-6
LID - 10.1136/medethics-2012-100942 [doi]
AB  - Dyck and Allen's criticisms of current systems of governance are well founded, at
      least in some jurisdictions. Their desire to halt the expansion and
      intensification of research ethics governance is to be applauded. However, their 
      listed categories of research to be exempted from mandatory review may not create
      a better system.
FAU - Israel, Mark
AU  - Israel M
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20121002
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
CON - J Med Ethics. 2013 Aug;39(8):517-20. PMID: 22865925
CIN - J Med Ethics. 2013 Aug;39(8):527-8. PMID: 23118467
MH  - *Beneficence
MH  - Biomedical Research/*ethics
MH  - Ethics Committees, Research/*economics/*ethics
MH  - *Ethics, Research
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - *Personal Autonomy
MH  - Research Personnel/*ethics
MH  - *Social Justice
OTO - NOTNLM
OT  - Ethics Committees/Consultation
OT  - Research Ethics
EDAT- 2012/10/04 06:00
MHDA- 2014/01/15 06:00
CRDT- 2012/10/04 06:00
PHST- 2012/10/04 06:00 [entrez]
PHST- 2012/10/04 06:00 [pubmed]
PHST- 2014/01/15 06:00 [medline]
AID - medethics-2012-100942 [pii]
AID - 10.1136/medethics-2012-100942 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Aug;39(8):525-6. doi: 10.1136/medethics-2012-100942. Epub 2012
      Oct 2.


PMID- 23033416
OWN - NLM
STAT- MEDLINE
DCOM- 20121204
LR  - 20181202
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 345
DP  - 2012 Oct 2
TI  - "Ethics Man" misses mark: most bioethicists are not thugs.
PG  - e6549
LID - 10.1136/bmj.e6549 [doi]
LID - bmj.e6549 [pii]
FAU - Crites, Joshua S
AU  - Crites JS
FAU - Volpe, Rebecca L
AU  - Volpe RL
LA  - eng
PT  - Letter
PT  - Comment
DEP - 20121002
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
SB  - IM
CON - BMJ. 2012;345:e5802. PMID: 22945953
MH  - *Bioethics
MH  - Humans
EDAT- 2012/10/04 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/10/04 06:00
PHST- 2012/10/04 06:00 [entrez]
PHST- 2012/10/04 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1136/bmj.e6549 [doi]
PST - epublish
SO  - BMJ. 2012 Oct 2;345:e6549. doi: 10.1136/bmj.e6549.


PMID- 23033377
OWN - NLM
STAT- MEDLINE
DCOM- 20121204
LR  - 20181023
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 345
DP  - 2012 Oct 2
TI  - Germany opposes EU plans for regulating clinical trials owing to lack of ethical 
      standards.
PG  - e6640
LID - 10.1136/bmj.e6640 [doi]
LID - bmj.e6640 [pii]
FAU - Tuffs, Annette
AU  - Tuffs A
LA  - eng
PT  - News
DEP - 20121002
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
SB  - IM
MH  - Clinical Trials as Topic/*ethics/legislation & jurisprudence/*standards
MH  - Codes of Ethics/*legislation & jurisprudence
MH  - Drug Approval/legislation & jurisprudence
MH  - Drug Industry/ethics/legislation & jurisprudence/standards
MH  - Ethics Committees/*ethics/*legislation & jurisprudence
MH  - *Ethics, Medical
MH  - *European Union
MH  - Germany
MH  - Humans
MH  - Leadership
MH  - Multicenter Studies as Topic/*ethics/legislation & jurisprudence/*standards
MH  - National Health Programs/*ethics/*legislation & jurisprudence/standards
MH  - Patient Safety/*legislation & jurisprudence/standards
MH  - Quality Assurance, Health Care/ethics/legislation & jurisprudence/standards
MH  - Research Design/legislation & jurisprudence/standards
MH  - *Social Control, Formal
EDAT- 2012/10/04 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/10/04 06:00
PHST- 2012/10/04 06:00 [entrez]
PHST- 2012/10/04 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1136/bmj.e6640 [doi]
PST - epublish
SO  - BMJ. 2012 Oct 2;345:e6640. doi: 10.1136/bmj.e6640.


PMID- 23033301
OWN - NLM
STAT- MEDLINE
DCOM- 20121121
LR  - 20121003
IS  - 1107-0625 (Print)
IS  - 1107-0625 (Linking)
VI  - 17
IP  - 3
DP  - 2012 Jul-Sep
TI  - Science ethics education: effects of a short lecture on plagiarism on the
      knowledge of young medical researchers.
PG  - 570-4
AB  - PURPOSE: Plagiarism is the most common form of scientific fraud. It is agreed
      that the best preventive measure is education of young scientists on basic
      principles of responsible conduct of research and writing. The purpose of this
      article was to contribute to the students' knowledge and adoption of the rules of
      scientific writing. METHODS: A 45 min lecture was delivered to 98 attendees
      during 3 courses on science ethics. Before and after the course the attendees
      fulfilled an especially designed questionnaire with 13 questions, specifically
      related to the definition and various types of plagiarism and self-plagiarism.
      RESULTS: Although considering themselves as insufficiently educated in science
      ethics, the majority of the attendees responded correctly to almost all questions
      even before the course, with percentages of correct responses to the specific
      question varying from 45.9-85.7%. After completion of the course, these
      percentages were significantly (p<0.01) higher, ranging from 66.3-98.8%. The
      percentage of improvement of the knowledge about plagiarism ranged from 9.18-
      42.86%. The percentage of impairment ranged from 1.02- 16.33%, the latter being
      related to the question on correct citing unpublished materials of other people; 
      only for this question the percentage of impairment (16.33%) was greater than the
      percentage of improvement (11.22%). CONCLUSION: Even a short lecture focused on
      plagiarism contributed to the students' awareness that there are many forms of
      plagiarism, and that plagiarism is a serious violation of science ethics. This
      result confirms the largely accepted opinion that education is the best means in 
      preventing plagiarism.
FAU - Brkic, S
AU  - Brkic S
AD  - University of Novi Sad, Medical Faculty, Novi Sad, Serbia. brkics@uns.ac.rs
FAU - Bogdanovic, G
AU  - Bogdanovic G
FAU - Vuckovic-Dekic, Lj
AU  - Vuckovic-Dekic Lj
FAU - Gavrilovic, D
AU  - Gavrilovic D
FAU - Kezic, I
AU  - Kezic I
LA  - eng
PT  - Journal Article
PL  - Cyprus
TA  - J BUON
JT  - Journal of B.U.ON. : official journal of the Balkan Union of Oncology
JID - 100883428
SB  - IM
MH  - Adult
MH  - Ethics, Research/*education
MH  - Female
MH  - Humans
MH  - *Knowledge
MH  - Male
MH  - Middle Aged
MH  - *Plagiarism
MH  - *Research Personnel
EDAT- 2012/10/04 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/10/04 06:00
PHST- 2012/10/04 06:00 [entrez]
PHST- 2012/10/04 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
PST - ppublish
SO  - J BUON. 2012 Jul-Sep;17(3):570-4.


PMID- 23032817
OWN - NLM
STAT- MEDLINE
DCOM- 20130226
LR  - 20191112
IS  - 0974-5130 (Electronic)
IS  - 0377-4929 (Linking)
VI  - 55
IP  - 3
DP  - 2012 Jul-Sep
TI  - The Hippocratic oath: a comparative analysis of the ancient text's relevance to
      American and Indian modern medicine.
PG  - 279-82
AB  - Hippocrates (460-375 B.C.), an ancient Greek physician considered the "Father of 
      Medicine," constructed the groundwork for the principles of ethics in medicine
      over 2,500 years ago in his establishment of the Hippocratic Oath. One of the
      oldest binding documents in history, the text has remained the ethical template
      for physicians to this day. The changing cultural and social environment of
      modern society, accompanied by the advancement in scientific knowledge and
      therapeutic tools, has surfaced the need to reframe ethical perspective in modern
      medicine. Progress in aspects such as organ transplantation, stem cell
      technology, and genetic engineering has welcomed a new set of ethical dilemmas.
      These dilemmas have become intimately intertwined with the impact of
      commercialization, as seen by the interplay between legislation, health care, and
      pharmaceutical businesses. This paper seeks to dissect the principles of the
      original Hippocratic Oath and analyze the template in relation to the ethical
      dilemmas presented by contemporary medicine. Examination will provide a deeper
      understanding of the paradigm shift in modern medical ethics. Both the value of
      the Oath and the level of awareness of modern ethical dilemmas through the lens
      of American and Indian medical graduates will be assessed.
FAU - Jhala, Chandrakant I
AU  - Jhala CI
FAU - Jhala, Khushboo N
AU  - Jhala KN
LA  - eng
PT  - Editorial
PL  - India
TA  - Indian J Pathol Microbiol
JT  - Indian journal of pathology & microbiology
JID - 7605904
SB  - IM
MH  - Clinical Medicine/*economics/*methods
MH  - *Ethics, Clinical
MH  - *Hippocratic Oath
MH  - Humans
EDAT- 2012/10/04 06:00
MHDA- 2013/02/27 06:00
CRDT- 2012/10/04 06:00
PHST- 2012/10/04 06:00 [entrez]
PHST- 2012/10/04 06:00 [pubmed]
PHST- 2013/02/27 06:00 [medline]
AID - IndianJPatholMicrobiol_2012_55_3_279_101730 [pii]
AID - 10.4103/0377-4929.101730 [doi]
PST - ppublish
SO  - Indian J Pathol Microbiol. 2012 Jul-Sep;55(3):279-82. doi:
      10.4103/0377-4929.101730.


PMID- 23031363
OWN - NLM
STAT- MEDLINE
DCOM- 20130502
LR  - 20220311
IS  - 1879-1484 (Electronic)
IS  - 0021-9150 (Linking)
VI  - 225
IP  - 2
DP  - 2012 Dec
TI  - Omega-3 fatty acids: benefits for cardio-cerebro-vascular diseases.
PG  - 291-5
LID - 10.1016/j.atherosclerosis.2012.09.006 [doi]
LID - S0021-9150(12)00619-3 [pii]
AB  - BACKGROUND AND PURPOSE: Intracranial artery stenosis (ICAS) is a narrowing of an 
      intracranial artery, which is a common etiology for ischemic stroke. In this
      commentary, we review key aspects of the discrimination between non-stroke
      controls and ischemic stroke patients on the background of phospholipid
      omega3-fatty acid (DHA, EPA) composition. The discussion is embedded in the
      presentation of general effects of long-chain omega3 polyunsaturated fatty acids 
      (PUFAs) in cardio-cerebro-vascular diseases (CCVDs) and Alzheimer dementia (AD). 
      SUMMARY OF COMMENTARY: ICAS is a common stroke subtype and has emerged as a major
      factor in recurrent stroke and vascular mortality. DHA and EPA are important
      fatty acids to distinguish between NCAS (no cerebral arteriosclerotic stenosis)
      and ICAS in stroke. The risk of ICAS is inversely correlated with the DHA content
      in phospholipids. Furthermore, a mechanistic explanation has been proposed for
      the beneficial effects of PUFAs in CCVDs and AD. CONCLUSIONS: Whereas the
      beneficial effects of EPA/DHA for cardiovascular diseases and stroke seem to be
      beyond question, preventive effects in patients with very mild cognitive
      dysfunction and beginning Alzheimer's disease undoubtedly need confirmation by
      larger clinical trials. A collaborative international basic science approach is
      warranted considering cautiously designed studies in order to avoid ethical
      problems.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Siegel, G
AU  - Siegel G
AD  - Charite - University Clinic Berlin, D-14195 Berlin, Germany.
      guenter.siegel@charite.de
FAU - Ermilov, E
AU  - Ermilov E
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120918
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
RN  - 0 (Cardiovascular Agents)
RN  - 0 (Fatty Acids, Omega-3)
SB  - IM
MH  - Alzheimer Disease/prevention & control
MH  - Cardiovascular Agents/*administration & dosage
MH  - Cardiovascular Diseases/*prevention & control
MH  - Cerebrovascular Disorders/*prevention & control
MH  - Constriction, Pathologic
MH  - Dementia, Vascular/prevention & control
MH  - *Diet
MH  - *Dietary Supplements
MH  - Fatty Acids, Omega-3/*administration & dosage
MH  - Humans
MH  - Intracranial Arterial Diseases/prevention & control
MH  - Nutrition Policy
MH  - Stroke/prevention & control
EDAT- 2012/10/04 06:00
MHDA- 2013/05/03 06:00
CRDT- 2012/10/04 06:00
PHST- 2012/09/05 00:00 [received]
PHST- 2012/09/07 00:00 [accepted]
PHST- 2012/10/04 06:00 [entrez]
PHST- 2012/10/04 06:00 [pubmed]
PHST- 2013/05/03 06:00 [medline]
AID - S0021-9150(12)00619-3 [pii]
AID - 10.1016/j.atherosclerosis.2012.09.006 [doi]
PST - ppublish
SO  - Atherosclerosis. 2012 Dec;225(2):291-5. doi:
      10.1016/j.atherosclerosis.2012.09.006. Epub 2012 Sep 18.


PMID- 23030795
OWN - NLM
STAT- MEDLINE
DCOM- 20130904
LR  - 20191210
IS  - 1557-8070 (Electronic)
IS  - 1557-8070 (Linking)
VI  - 12
IP  - 10
DP  - 2012 Oct
TI  - An ecological compass for planetary engineering.
PG  - 985-97
LID - 10.1089/ast.2011.0796 [doi]
AB  - Proposals to address present-day global warming through the large-scale
      application of technology to the climate system, known as geoengineering, raise
      questions of environmental ethics relevant to the broader issue of planetary
      engineering. These questions have also arisen in the scientific literature as
      discussions of how to terraform a planet such as Mars or Venus in order to make
      it more Earth-like and habitable. Here we draw on insights from terraforming and 
      environmental ethics to develop a two-axis comparative tool for ethical
      frameworks that considers the intrinsic or instrumental value placed upon
      organisms, environments, planetary systems, or space. We apply this analysis to
      the realm of planetary engineering, such as terraforming on Mars or
      geoengineering on present-day Earth, as well as to questions of planetary
      protection and space exploration.
FAU - Haqq-Misra, Jacob
AU  - Haqq-Misra J
AD  - Blue Marble Space Institute of Science, Seattle, WA 98145, USA. jacob@bmsis.org
LA  - eng
PT  - Journal Article
DEP - 20121003
PL  - United States
TA  - Astrobiology
JT  - Astrobiology
JID - 101088083
SB  - IM
MH  - *Earth, Planet
MH  - Ecology
MH  - Ecosystem
MH  - *Engineering
MH  - *Exobiology
MH  - *Extraterrestrial Environment
MH  - Human Activities
MH  - *Planets
EDAT- 2012/10/04 06:00
MHDA- 2013/09/05 06:00
CRDT- 2012/10/04 06:00
PHST- 2012/10/04 06:00 [entrez]
PHST- 2012/10/04 06:00 [pubmed]
PHST- 2013/09/05 06:00 [medline]
AID - 10.1089/ast.2011.0796 [doi]
PST - ppublish
SO  - Astrobiology. 2012 Oct;12(10):985-97. doi: 10.1089/ast.2011.0796. Epub 2012 Oct
      3.


PMID- 23008403
OWN - NLM
STAT- MEDLINE
DCOM- 20121214
LR  - 20211021
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Linking)
VI  - 79
IP  - 13 Suppl 1
DP  - 2012 Sep 25
TI  - Clinical trial design for endovascular ischemic stroke intervention.
PG  - S221-33
AB  - BACKGROUND: Randomized, double-blinded, placebo-controlled trials have
      significant impact on clinical practice. The ultimate goal of a clinical trial of
      therapy for acute ischemic stroke (AIS) is to compare 2 interventions. Challenges
      may include interventional therapy standardization, enrollment rate, patient
      selection, biases, data and safety monitoring, reporting, and financial and
      logistical support. METHOD: Selected randomized and single-arm prospective AIS
      trial designs. Clinical trial elements and their challenges are reviewed.
      Innovative designs and proposed recommendations to overcome some of the specific 
      challenges and limitations are discussed. RESULTS: AIS therapy trials have
      specific challenges related to ethical issues, enrollment rate, outcome measures,
      limited time to treatment, efficacy, safety, and limited or variable operator
      experience with complex technology in a delicate end organ. Proposed suggestions 
      for improving trial design include the following: incorporation of a lead-in
      phase; careful patient and outcome measure selection; historical, concurrent, or 
      hybrid controls; open data access; and a Bayesian approach. An open data paradigm
      may facilitate creation of computerized prediction models for future trials
      (minimizing cost by decreasing sample size or providing futility analyses and
      directing resources to other trials). Collaborative, consortium, and network
      infrastructures may allow more effective and efficient study completion.
      Self-learning, self-correcting trials with intrinsic flexibility to adapt may
      help future clinical trial design in AIS. CONCLUSION: The randomized clinical
      trial design in AIS endovascular therapy is challenging. Lead-in phases, careful 
      patient selection, use of innovative outcome measures, control groups, and newer 
      clinical trial design may enhance conduct of future trials, their validity, and
      their results.
FAU - Zaidat, Osama O
AU  - Zaidat OO
AD  - Department of Neurology, Medical College of Wisconsin and Froedtert Hospital,
      Milwaukee, WI, USA. szaidat@mcw.edu
FAU - Liebeskind, David S
AU  - Liebeskind DS
FAU - Edgell, Randall C
AU  - Edgell RC
FAU - Amlie-Lefond, Catherine M
AU  - Amlie-Lefond CM
FAU - Kalia, Junaid S
AU  - Kalia JS
FAU - Alexandrov, Andrei V
AU  - Alexandrov AV
LA  - eng
GR  - K24 NS072272/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
SB  - IM
MH  - Animals
MH  - Brain Ischemia/diagnosis/*therapy
MH  - Clinical Protocols
MH  - Clinical Trials as Topic/*methods
MH  - Early Medical Intervention/*methods
MH  - Endovascular Procedures/*methods
MH  - Humans
MH  - Stroke/diagnosis/*therapy
PMC - PMC4109233
EDAT- 2012/10/04 06:00
MHDA- 2012/12/15 06:00
CRDT- 2012/09/26 06:00
PHST- 2012/09/26 06:00 [entrez]
PHST- 2012/10/04 06:00 [pubmed]
PHST- 2012/12/15 06:00 [medline]
AID - 79/13_Supplement_1/S221 [pii]
AID - 10.1212/WNL.0b013e31826992cf [doi]
PST - ppublish
SO  - Neurology. 2012 Sep 25;79(13 Suppl 1):S221-33. doi: 10.1212/WNL.0b013e31826992cf.


PMID- 23029386
OWN - NLM
STAT- MEDLINE
DCOM- 20130305
LR  - 20220409
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 9
DP  - 2012
TI  - Peer review of grant applications: criteria used and qualitative study of
      reviewer practices.
PG  - e46054
LID - 10.1371/journal.pone.0046054 [doi]
AB  - BACKGROUND: Peer review of grant applications has been criticized as lacking
      reliability. Studies showing poor agreement among reviewers supported this
      possibility but usually focused on reviewers' scores and failed to investigate
      reasons for disagreement. Here, our goal was to determine how reviewers rate
      applications, by investigating reviewer practices and grant assessment criteria. 
      METHODS AND FINDINGS: We first collected and analyzed a convenience sample of
      French and international calls for proposals and assessment guidelines, from
      which we created an overall typology of assessment criteria comprising nine
      domains relevance to the call for proposals, usefulness, originality,
      innovativeness, methodology, feasibility, funding, ethical aspects, and writing
      of the grant application. We then performed a qualitative study of reviewer
      practices, particularly regarding the use of assessment criteria, among reviewers
      of the French Academic Hospital Research Grant Agencies (Programmes Hospitaliers 
      de Recherche Clinique, PHRCs). Semi-structured interviews and observation
      sessions were conducted. Both the time spent assessing each grant application and
      the assessment methods varied across reviewers. The assessment criteria
      recommended by the PHRCs were listed by all reviewers as frequently evaluated and
      useful. However, use of the PHRC criteria was subjective and varied across
      reviewers. Some reviewers gave the same weight to each assessment criterion,
      whereas others considered originality to be the most important criterion (12/34),
      followed by methodology (10/34) and feasibility (4/34). Conceivably, this
      variability might adversely affect the reliability of the review process, and
      studies evaluating this hypothesis would be of interest. CONCLUSIONS: Variability
      across reviewers may result in mistrust among grant applicants about the review
      process. Consequently, ensuring transparency is of the utmost importance.
      Consistency in the review process could also be improved by providing common
      definitions for each assessment criterion and uniform requirements for grant
      application submissions. Further research is needed to assess the feasibility and
      acceptability of these measures.
FAU - Abdoul, Hendy
AU  - Abdoul H
AD  - AP-HP, Hopital Robert Debre, Unite d'epidemiologie clinique, Paris, France.
      hendy.abdoul@rdb.aphp.fr
FAU - Perrey, Christophe
AU  - Perrey C
FAU - Amiel, Philippe
AU  - Amiel P
FAU - Tubach, Florence
AU  - Tubach F
FAU - Gottot, Serge
AU  - Gottot S
FAU - Durand-Zaleski, Isabelle
AU  - Durand-Zaleski I
FAU - Alberti, Corinne
AU  - Alberti C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120928
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Data Collection
MH  - Financing, Organized/*methods/standards
MH  - France
MH  - Humans
MH  - Intellectual Property
MH  - Peer Review, Research/*methods/standards
MH  - Qualitative Research
MH  - Research/economics
PMC - PMC3460995
EDAT- 2012/10/03 06:00
MHDA- 2013/03/06 06:00
CRDT- 2012/10/03 06:00
PHST- 2012/06/04 00:00 [received]
PHST- 2012/08/28 00:00 [accepted]
PHST- 2012/10/03 06:00 [entrez]
PHST- 2012/10/03 06:00 [pubmed]
PHST- 2013/03/06 06:00 [medline]
AID - 10.1371/journal.pone.0046054 [doi]
AID - PONE-D-12-17022 [pii]
PST - ppublish
SO  - PLoS One. 2012;7(9):e46054. doi: 10.1371/journal.pone.0046054. Epub 2012 Sep 28.


PMID- 23028924
OWN - NLM
STAT- MEDLINE
DCOM- 20130225
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 9
DP  - 2012
TI  - Use of temperature for standardizing the progression of Francisella tularensis in
      mice.
PG  - e45310
LID - 10.1371/journal.pone.0045310 [doi]
AB  - The study of infectious agents, their pathogenesis, the host response and the
      evaluation of newly developed countermeasures often requires the use of a living 
      system. Murine models are frequently used to undertake such investigations with
      the caveat that non-biased measurements to assess the progression of infection
      are underutilized. Instead, murine models predominantly rely on symptomology
      exhibited by the animal to evaluate the state of the animal's health and to
      determine when euthanasia should be performed. In this study, we used
      subcutaneous temperature as a non-subjective measurement to follow and compare
      infection in mice inoculated with Francisella tularensis, a Gram-negative
      pathogen that produces an acute and fatal illness in mice. A reproducible
      temperature pattern defined by three temperature phases (normal, febrile and
      hypothermic) was identified in all mice infected with F. tularensis, regardless
      of the infecting strain. More importantly and for the first time a
      non-subjective, ethical, and easily determined surrogate endpoint for death based
      on a temperature, termed drop point, was identified and validated with
      statistical models. In comparative survival curve analyses for F. tularensis
      strains with differing virulence, the drop point temperature yielded the same
      results as those obtained using observed time to death. Incorporation of
      temperature measurements to evaluate F. tularensis was standardized based on
      statistical models to provide a new level of robustness for comparative analyses 
      in mice. These findings should be generally applicable to other pathogens that
      produce acute febrile disease in animal models and offers an important tool for
      understanding and following the infection process.
FAU - Molins, Claudia R
AU  - Molins CR
AD  - Division of Vector-Borne Diseases, Centers for Disease Control and Prevention,
      Fort Collins, Colorado, United State of America. CMolins@cdc.gov
FAU - Delorey, Mark J
AU  - Delorey MJ
FAU - Young, John W
AU  - Young JW
FAU - Yockey, Brook M
AU  - Yockey BM
FAU - Belisle, John T
AU  - Belisle JT
FAU - Schriefer, Martin E
AU  - Schriefer ME
FAU - Petersen, Jeannine M
AU  - Petersen JM
LA  - eng
GR  - U54 AI065357/AI/NIAID NIH HHS/United States
GR  - U54AI065357-01/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120924
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Animals
MH  - Female
MH  - Francisella tularensis/*pathogenicity
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - *Temperature
MH  - Tularemia/*microbiology/pathology/*physiopathology
MH  - Virulence
PMC - PMC3454384
EDAT- 2012/10/03 06:00
MHDA- 2013/02/26 06:00
CRDT- 2012/10/03 06:00
PHST- 2012/05/10 00:00 [received]
PHST- 2012/08/21 00:00 [accepted]
PHST- 2012/10/03 06:00 [entrez]
PHST- 2012/10/03 06:00 [pubmed]
PHST- 2013/02/26 06:00 [medline]
AID - 10.1371/journal.pone.0045310 [doi]
AID - PONE-D-12-13716 [pii]
PST - ppublish
SO  - PLoS One. 2012;7(9):e45310. doi: 10.1371/journal.pone.0045310. Epub 2012 Sep 24.


PMID- 23028214
OWN - NLM
STAT- MEDLINE
DCOM- 20130117
LR  - 20211021
IS  - 1178-2013 (Electronic)
IS  - 1176-9114 (Linking)
VI  - 7
DP  - 2012
TI  - Differentiation of human stem cells is promoted by amphiphilic pluronic block
      copolymers.
PG  - 4849-60
LID - 10.2147/IJN.S31949 [doi]
AB  - Stem cell usage provides novel avenues of tissue regeneration and therapeutics
      across disciplines. Apart from ethical considerations, the selection and
      amplification of donor stem cells remain a challenge. Various biopolymers with a 
      wide range of properties have been used extensively to deliver biomolecules such 
      as drugs, growth factors and nucleic acids, as well as to provide biomimetic
      surface for cellular adhesion. Using human tooth germ stem cells with high
      proliferation and transformation capacity, we have investigated a range of
      biopolymers to assess their potential for tissue engineering. Tolerability,
      toxicity, and their ability to direct differentiation were evaluated. The
      majority of pluronics, consisting of both hydrophilic and hydrophobic
      poly(ethylene oxide) chains, either exerted cytotoxicity or had no significant
      effect on human tooth germ stem cells; whereas F68 increased the multi-potency of
      stem cells, and efficiently transformed them into osteogenic, chondrogenic, and
      adipogenic tissues. The data suggest that differentiation and maturation of stem 
      cells can be promoted by selecting the appropriate mechanical and chemical
      properties of polymers. It has been shown for the first time that F68, with its
      unique molecular characteristics, has a great potential to increase the
      differentiation of cells, which may lead to the development of new tissue
      engineering strategies in regenerative medicine.
FAU - Dogan, Aysegul
AU  - Dogan A
AD  - Department of Genetics and BioEngineering, College of Engineering and
      Architecture, Yeditepe University, Istanbul, Turkey.
FAU - Yalvac, Mehmet E
AU  - Yalvac ME
FAU - Sahin, Fikrettin
AU  - Sahin F
FAU - Kabanov, Alexander V
AU  - Kabanov AV
FAU - Palotas, Andras
AU  - Palotas A
FAU - Rizvanov, Albert A
AU  - Rizvanov AA
LA  - eng
GR  - R01 CA089225/CA/NCI NIH HHS/United States
GR  - R01 CA116591/CA/NCI NIH HHS/United States
GR  - 1R01 CA116591/CA/NCI NIH HHS/United States
GR  - 2R01 CA89225/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120910
PL  - New Zealand
TA  - Int J Nanomedicine
JT  - International journal of nanomedicine
JID - 101263847
RN  - 106392-12-5 (Poloxamer)
SB  - IM
MH  - Adolescent
MH  - Cell Culture Techniques/methods
MH  - Cell Differentiation
MH  - Cell Proliferation
MH  - Cells, Cultured
MH  - Humans
MH  - Hydrophobic and Hydrophilic Interactions
MH  - Osteoblasts/*cytology/*physiology
MH  - Osteogenesis/physiology
MH  - Poloxamer/*chemistry
MH  - Stem Cells/*cytology/*physiology
MH  - Tooth Germ/*cytology/*physiology
PMC - PMC3441230
OTO - NOTNLM
OT  - biopolymer
OT  - differentiation
OT  - human tooth germ stem cell (hTGSC)
OT  - mesenchymal stem cell
OT  - pluronic
OT  - toxicity
EDAT- 2012/10/03 06:00
MHDA- 2013/01/18 06:00
CRDT- 2012/10/03 06:00
PHST- 2012/10/03 06:00 [entrez]
PHST- 2012/10/03 06:00 [pubmed]
PHST- 2013/01/18 06:00 [medline]
AID - 10.2147/IJN.S31949 [doi]
AID - ijn-7-4849 [pii]
PST - ppublish
SO  - Int J Nanomedicine. 2012;7:4849-60. doi: 10.2147/IJN.S31949. Epub 2012 Sep 10.


PMID- 23028009
OWN - NLM
STAT- MEDLINE
DCOM- 20130226
LR  - 20121002
IS  - 1943-5665 (Electronic)
IS  - 1546-3222 (Linking)
VI  - 9
IP  - 4
DP  - 2012 Oct
TI  - Clinical year in review III: asthma, chronic obstructive pulmonary disease,
      environmental and occupational lung disease, and ethics and end-of-life care.
PG  - 197-203
LID - 10.1513/pats.201206-032TT [doi]
FAU - Sutherland, E Rand
AU  - Sutherland ER
AD  - Division of Pulmonary and Critical Care Medicine, National Jewish Health, 1400
      Jackson St., J-201, Denver, CO 80206, USA. sutherlande@njhealth.org
FAU - Sciurba, Frank C
AU  - Sciurba FC
FAU - Glazer, Craig S
AU  - Glazer CS
FAU - Halpern, Scott D
AU  - Halpern SD
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Proc Am Thorac Soc
JT  - Proceedings of the American Thoracic Society
JID - 101203596
SB  - IM
MH  - Asthma/therapy
MH  - Environmental Exposure
MH  - Humans
MH  - Lung Diseases/*therapy
MH  - Occupational Diseases/*therapy
MH  - Pulmonary Disease, Chronic Obstructive/diagnosis/physiopathology/therapy
MH  - Terminal Care/*ethics
EDAT- 2012/10/03 06:00
MHDA- 2013/02/27 06:00
CRDT- 2012/10/03 06:00
PHST- 2012/10/03 06:00 [entrez]
PHST- 2012/10/03 06:00 [pubmed]
PHST- 2013/02/27 06:00 [medline]
AID - 9/4/197 [pii]
AID - 10.1513/pats.201206-032TT [doi]
PST - ppublish
SO  - Proc Am Thorac Soc. 2012 Oct;9(4):197-203. doi: 10.1513/pats.201206-032TT.


PMID- 23027523
OWN - NLM
STAT- MEDLINE
DCOM- 20130225
LR  - 20121002
IS  - 1741-2889 (Electronic)
IS  - 1367-4935 (Linking)
VI  - 16
IP  - 3
DP  - 2012 Sep
TI  - 'Making the bad things seem better': coping in children receiving healthcare.
PG  - 305-13
LID - 10.1177/1367493512443907 [doi]
AB  - The focus of children's healthcare literature has been the delivery of services
      to children and their parents, little attention has been paid to how children
      cope with receiving such care. In this paper we use a literature scoping method
      to bring together the literature on how medical talk can engage or isolate
      children, consider the environmental factors which can help children to be
      engaged and discuss an ethical symmetry approach. We propose that an ethical
      symmetry approach would provide a framework for healthcare teams to explore how
      to optimize children's engagement with their healthcare.
FAU - Randall, Duncan
AU  - Randall D
AD  - Nursing and Physiotherapy, School of Health and Population Sciences, College of
      Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, UK.
      d.c.randall@bham.ac.uk
FAU - Hallowell, Leanne
AU  - Hallowell L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - J Child Health Care
JT  - Journal of child health care : for professionals working with children in the
      hospital and community
JID - 9806360
MH  - *Adaptation, Psychological
MH  - Child
MH  - Child, Preschool
MH  - Humans
MH  - Nurse-Patient Relations
MH  - Patient Care/*psychology
MH  - Quality of Health Care
EDAT- 2012/10/03 06:00
MHDA- 2013/02/26 06:00
CRDT- 2012/10/03 06:00
PHST- 2012/10/03 06:00 [entrez]
PHST- 2012/10/03 06:00 [pubmed]
PHST- 2013/02/26 06:00 [medline]
AID - 1367493512443907 [pii]
AID - 10.1177/1367493512443907 [doi]
PST - ppublish
SO  - J Child Health Care. 2012 Sep;16(3):305-13. doi: 10.1177/1367493512443907.


PMID- 23027144
OWN - NLM
STAT- MEDLINE
DCOM- 20130226
LR  - 20191112
IS  - 1543-2777 (Electronic)
IS  - 0736-5829 (Linking)
VI  - 29
IP  - 4
DP  - 2012 Oct
TI  - Thinking ethically about professional practice in adapted physical activity.
PG  - 295-309
AB  - There has been little critical exploration of the ethical issues that arise in
      professional practice common to adapted physical activity. We cannot avoid moral 
      issues as we inevitably will act in ways that will negatively affect the
      well-being of others. We will make choices, which in our efforts to support
      others, may hurt by violating dignity or infringing on rights. The aim of this
      paper is to open a dialogue on what constitutes ethical practice in adapted
      physical activity. Ethical theories including principlism, virtue ethics, ethics 
      of care, and relational ethics provide a platform for addressing questions of
      right and good and wrong and bad in the field of adapted physical activity.
      Unpacking of stories of professional practice (including sacred, secret, and
      cover stories) against the lived experiences of persons experiencing disability
      will create a knowledge landscape in adapted physical activity that is sensitive 
      to ethical reflection.
FAU - Goodwin, Donna L
AU  - Goodwin DL
AD  - Faculty of Physical Education and Recreation, University of Alberta, Edmonton,
      Alberta, Canada.
FAU - Rossow-Kimball, Brenda
AU  - Rossow-Kimball B
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Adapt Phys Activ Q
JT  - Adapted physical activity quarterly : APAQ
JID - 8701671
SB  - IM
MH  - Disabled Persons/education/*psychology
MH  - Ethical Theory
MH  - Humans
MH  - Knowledge
MH  - *Motor Activity
MH  - Physical Education and Training
MH  - Principle-Based Ethics
MH  - Professional Practice/*ethics
MH  - Professional Role
MH  - Professional-Patient Relations/*ethics
MH  - Virtues
EDAT- 2012/10/03 06:00
MHDA- 2013/02/27 06:00
CRDT- 2012/10/03 06:00
PHST- 2012/10/03 06:00 [entrez]
PHST- 2012/10/03 06:00 [pubmed]
PHST- 2013/02/27 06:00 [medline]
AID - 10.1123/apaq.29.4.295 [doi]
PST - ppublish
SO  - Adapt Phys Activ Q. 2012 Oct;29(4):295-309. doi: 10.1123/apaq.29.4.295.


PMID- 23026628
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20181202
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 44
IP  - 8
DP  - 2012 Oct
TI  - Expression of pancreatic endocrine markers by mesenchymal stem cells from human
      adipose tissue.
PG  - 2495-6
LID - 10.1016/j.transproceed.2012.07.036 [doi]
LID - S0041-1345(12)00732-4 [pii]
AB  - Mesenchymal stem cells (MSCs) from human adipose tissue have a great potential
      for use in cell therapy due to their ease of isolation, expansion, and
      differentiation, besides the relative acceptance from the ethical point of view. 
      Our intention was to isolate and promote in vitro expansion and differentiation
      of MSCs from human adipose tissue into cells with a pancreatic endocrine
      phenotype. Human adipose tissue obtained from patients undergoing abdominal
      dermolipectomy was digested with type I collagenase. MSCs isolated by plastic
      adherence and characterized by cytochemistry and FACS were expanded in vitro. MSC
      differentiation into an endocrine phenotype was induced over 2 to 4 months with
      high glucose (25 mmol/L) media containing nicotinamide, exendin-4, and
      2-mercaptoethanol. Insulin and glucagon expressions were analyzed by
      immunofluorescence. Cells isolated from human adipose tissue and expanded in
      vitro expressed MSC markers as confirmed by FACS and cytochemistry. Insulin but
      not glucagon production by differentiated cells was demonstrated by
      immunofluorescence. MSCs isolated from human adipose tissue were induced to
      differentiate in vitro into an endocrine phenotype that expressed insulin.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Silva, A C
AU  - Silva AC
AD  - Centro de Ciencias Biologicas e da Saude, Pontificia Universidade Catolica do
      Parana, Curitiba, Brazil.
FAU - Percegona, L S
AU  - Percegona LS
FAU - Franca, A L
AU  - Franca AL
FAU - Dos Santos, T M
AU  - Dos Santos TM
FAU - Perini, C C
AU  - Perini CC
FAU - Gonzalez, P
AU  - Gonzalez P
FAU - Rebelatto, C L K
AU  - Rebelatto CL
FAU - Camara, N O S
AU  - Camara NO
FAU - Aita, C A M
AU  - Aita CA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - 0 (Biomarkers)
RN  - 0 (Insulin)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Abdominal Fat/*cytology
MH  - Biomarkers/metabolism
MH  - Cell Adhesion
MH  - *Cell Differentiation
MH  - Cell Proliferation
MH  - Cell Separation/methods
MH  - Flow Cytometry
MH  - Fluorescent Antibody Technique
MH  - Gene Expression Regulation
MH  - Glucose/metabolism
MH  - Humans
MH  - Insulin/genetics/*metabolism
MH  - Islets of Langerhans/*metabolism
MH  - Mesenchymal Stem Cells/*metabolism
MH  - Phenotype
MH  - Polymerase Chain Reaction
EDAT- 2012/10/03 06:00
MHDA- 2013/03/13 06:00
CRDT- 2012/10/03 06:00
PHST- 2012/10/03 06:00 [entrez]
PHST- 2012/10/03 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
AID - S0041-1345(12)00732-4 [pii]
AID - 10.1016/j.transproceed.2012.07.036 [doi]
PST - ppublish
SO  - Transplant Proc. 2012 Oct;44(8):2495-6. doi: 10.1016/j.transproceed.2012.07.036.


PMID- 23026627
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20151119
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 44
IP  - 8
DP  - 2012 Oct
TI  - Protective effects of human amniotic fluid stem cells in a model of aorta
      allograft vasculopathy in rats.
PG  - 2490-4
LID - 10.1016/j.transproceed.2012.07.022 [doi]
LID - S0041-1345(12)00718-X [pii]
AB  - BACKGROUND: Chronic allograft vasculopathy (CAV) is an important cause of graft
      loss. Considering the immune inflammatory events involved in the development of
      CAV, therapeutic approaches to target this process are of relevance. Human
      amniotic fluid-derived stem cells (hAFSCs), a class of fetal, pluripotent stem
      cells with intermediate characteristics between embryonic and adult stem cells,
      display immunomodulatory properties. hAFSCs express mesenchymal and embryonic
      markers, show high proliferation rates; however, they do not induce tumor
      formation, and their use does not raise ethical issues. Thus, we sought to
      investigate the effect of hAFSC on CAV in a model of aorta transplantation.
      METHODS: Orthotopic aorta transplantation was performed using Fisher (F344) rats 
      as donors and Lewis rats as recipients. Rats were divided into three groups:
      syngeneic (SYNG), untreated F344 receiving aorta from F344 (n = 8); allogeneic
      (ALLO), Lewis rats receiving allogeneic aorta from F344 (n = 8); and ALLO +
      hAFSC, ALLO rats treated with hAFSC (10(6) cells; n = 8). Histological analysis
      and immunohistochemistry were performed 30 days posttransplantation. RESULTS: The
      ALLO group developed a robust aortic neointimal formation (208.7 +/- 25.4 mum)
      accompanied by a significant high number of ED1+ (4845 +/- 841 cells/mm2) and
      CD43+ cells (4064 +/- 563 cells/mm2), and enhanced expression of alpha-smooth
      muscle actin in the neointima (25 +/- 6%). Treatment with hAFSC diminished
      neointimal thickness (180.7 +/- 23.7 mum) and induced a significant decrease of
      ED1+ (1100 +/- 276 cells/mm2), CD43+ cells (1080 +/- 309 cells/mum2), and
      alpha-smooth muscle actin expression 8 +/- 3% in the neointima. CONCLUSIONS:
      These preliminary results showed that hAFSC suppressed inflammation and
      myofibroblast migration to the intima, which may contribute to ameliorate
      vascular changes in CAV.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Santana, A C
AU  - Santana AC
AD  - Laboratory of Cellular, Genetic, and Molecular Nephrology, University of Sao
      Paulo School of Medicine, Sao Paulo, Brazil.
FAU - Delle, H
AU  - Delle H
FAU - Cavaglieri, R C
AU  - Cavaglieri RC
FAU - Lopes, M A B
AU  - Lopes MA
FAU - Francisco, R P V
AU  - Francisco RP
FAU - Zugaib, M
AU  - Zugaib M
FAU - Bydlowski, S P
AU  - Bydlowski SP
FAU - Noronha, I L
AU  - Noronha IL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - 0 (Actins)
RN  - 0 (Biomarkers)
RN  - 0 (smooth muscle actin, rat)
SB  - IM
MH  - Actins/metabolism
MH  - Amniotic Fluid/*cytology
MH  - Animals
MH  - Aorta, Abdominal/immunology/metabolism/pathology/*transplantation
MH  - Aortic Diseases/etiology/immunology/metabolism/pathology/*prevention & control
MH  - Biomarkers/metabolism
MH  - Cell Movement
MH  - Cells, Cultured
MH  - Fetal Stem Cells/immunology/metabolism/*transplantation
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Myofibroblasts/metabolism/pathology
MH  - Neointima
MH  - Organ Transplantation/*adverse effects
MH  - Pluripotent Stem Cells/immunology/metabolism/*transplantation
MH  - Rats
MH  - Rats, Inbred F344
MH  - Rats, Inbred Lew
MH  - Time Factors
EDAT- 2012/10/03 06:00
MHDA- 2013/03/13 06:00
CRDT- 2012/10/03 06:00
PHST- 2012/10/03 06:00 [entrez]
PHST- 2012/10/03 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
AID - S0041-1345(12)00718-X [pii]
AID - 10.1016/j.transproceed.2012.07.022 [doi]
PST - ppublish
SO  - Transplant Proc. 2012 Oct;44(8):2490-4. doi: 10.1016/j.transproceed.2012.07.022.


PMID- 23026544
OWN - NLM
STAT- MEDLINE
DCOM- 20131212
LR  - 20181202
IS  - 1873-6513 (Electronic)
IS  - 0885-3924 (Linking)
VI  - 45
IP  - 6
DP  - 2013 Jun
TI  - Continuous sedation (CS) until death: mapping the literature by bibliometric
      analysis.
PG  - 1073-1082.e10
LID - 10.1016/j.jpainsymman.2012.05.012 [doi]
LID - S0885-3924(12)00341-7 [pii]
AB  - CONTEXT: Sedation at the end of life, regardless of the nomenclature, is an
      increasingly debated practice at both clinical and bioethical levels. However,
      little is known about the characteristics and trends in scientific publications
      in this field of study. OBJECTIVES: This article presents a bibliometric analysis
      of the scientific publications on continuous sedation until death. METHODS: Four 
      electronic databases (MEDLINE, PubMed, Embase, and PsycINFO(R)) were searched for
      the indexed material published between 1945 and 2011. This search resulted in
      bibliographic data of 273 published outputs that were analyzed using bibliometric
      techniques. RESULTS: Data revealed a trend of increased scientific publication
      from the early 1990s. Published outputs, diverse in type (comments/letters,
      articles, reviews, case reports, editorials), were widely distributed across 94
      journals of varying scientific disciplines (medicine, nursing, palliative care,
      law, ethics). Most journals (72.3%) were classified under Medical and Health
      Sciences, with the Journal of Pain and Symptom Management identified as the major
      journal in the field covering 12.1% of the total publications. Empirical research
      articles, mostly of a quantitative design, originated from 17 countries. Although
      Japan and The Netherlands were found to be the leaders in research article
      productivity, it was the U.K. and the U.S. that ranked top in terms of the
      quantity of published outputs. CONCLUSION: This is the first bibliometric
      analysis on continuous sedation until death that can be used to inform future
      studies. Further research is needed to refine controversies on terminology and
      ethical acceptability of the practice, as well as conditions and modalities of
      its use.
CI  - Copyright (c) 2013 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. 
      All rights reserved.
FAU - Papavasiliou, Evangelia
AU  - Papavasiliou E
AD  - International Observatory on End-of-Life Care, Lancaster University, Lancaster,
      United Kingdom. e.papavasiliou@lancaster.ac.uk
FAU - Payne, Sheila
AU  - Payne S
FAU - Brearley, Sarah
AU  - Brearley S
FAU - Brown, Jayne
AU  - Brown J
FAU - Seymour, Jane
AU  - Seymour J
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120929
PL  - United States
TA  - J Pain Symptom Manage
JT  - Journal of pain and symptom management
JID - 8605836
RN  - 0 (Hypnotics and Sedatives)
SB  - IM
MH  - *Bibliometrics
MH  - Chronic Pain/*drug therapy/*mortality
MH  - Humans
MH  - Hypnotics and Sedatives/*therapeutic use
MH  - Incidence
MH  - Palliative Care/*statistics & numerical data
MH  - Periodicals as Topic/statistics & numerical data
MH  - Practice Patterns, Physicians'/statistics & numerical data
MH  - Risk Assessment
MH  - Stress, Psychological/*mortality/*prevention & control
MH  - Survival Analysis
MH  - Survival Rate
MH  - Terminal Care/statistics & numerical data
EDAT- 2012/10/03 06:00
MHDA- 2013/12/18 06:00
CRDT- 2012/10/03 06:00
PHST- 2012/02/15 00:00 [received]
PHST- 2012/05/11 00:00 [revised]
PHST- 2012/05/18 00:00 [accepted]
PHST- 2012/10/03 06:00 [entrez]
PHST- 2012/10/03 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
AID - S0885-3924(12)00341-7 [pii]
AID - 10.1016/j.jpainsymman.2012.05.012 [doi]
PST - ppublish
SO  - J Pain Symptom Manage. 2013 Jun;45(6):1073-1082.e10. doi:
      10.1016/j.jpainsymman.2012.05.012. Epub 2012 Sep 29.


PMID- 23026426
OWN - NLM
STAT- MEDLINE
DCOM- 20130107
LR  - 20121002
IS  - 1097-6809 (Electronic)
IS  - 0741-5214 (Linking)
VI  - 56
IP  - 4
DP  - 2012 Oct
TI  - Ethics of medical finance: when is enough too much?
PG  - 1153-4
LID - 10.1016/j.jvs.2012.08.047 [doi]
LID - S0741-5214(12)01815-0 [pii]
FAU - Jones, James W
AU  - Jones JW
AD  - Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston,
      TX, USA. jwjones@bcm.tmc.edu
FAU - McCullough, Laurence B
AU  - McCullough LB
LA  - eng
PT  - Editorial
PL  - United States
TA  - J Vasc Surg
JT  - Journal of vascular surgery
JID - 8407742
SB  - IM
MH  - Health Priorities/*economics/*ethics
MH  - Healthcare Financing/*ethics
MH  - Humans
MH  - Patient Selection/ethics
MH  - United States
EDAT- 2012/10/03 06:00
MHDA- 2013/01/08 06:00
CRDT- 2012/10/03 06:00
PHST- 2012/10/03 06:00 [entrez]
PHST- 2012/10/03 06:00 [pubmed]
PHST- 2013/01/08 06:00 [medline]
AID - S0741-5214(12)01815-0 [pii]
AID - 10.1016/j.jvs.2012.08.047 [doi]
PST - ppublish
SO  - J Vasc Surg. 2012 Oct;56(4):1153-4. doi: 10.1016/j.jvs.2012.08.047.


PMID- 23026016
OWN - NLM
STAT- MEDLINE
DCOM- 20130524
LR  - 20121211
IS  - 1873-6386 (Electronic)
IS  - 0160-2527 (Linking)
VI  - 35
IP  - 5-6
DP  - 2012 Sep-Dec
TI  - Formal training in forensic mental health: psychiatry and psychology.
PG  - 343-7
LID - 10.1016/j.ijlp.2012.09.010 [doi]
LID - S0160-2527(12)00073-8 [pii]
AB  - The field of forensic mental health has grown exponentially in the past decades
      to include forensic psychiatrists and psychologists serving as the primary
      experts to the court systems. However, many colleagues have chosen to pursue the 
      avenue of serving as forensic experts without obtaining formal training and
      experience. This article discusses the importance of formal education, training
      and experience for psychiatrists and psychologists working in forensic settings
      and the ethical implications that befall those who fail to obtain such
      credentials. Specific aspects of training and supervised experience are discussed
      in detail.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Sadoff, Robert L
AU  - Sadoff RL
AD  - Department of Psychiatry, University of Pennsylvania Perelman School of Medicine,
      United States. sadoffbobsadoff@aol.com
FAU - Dattilio, Frank M
AU  - Dattilio FM
LA  - eng
PT  - Journal Article
DEP - 20120928
PL  - Netherlands
TA  - Int J Law Psychiatry
JT  - International journal of law and psychiatry
JID - 7806862
SB  - IM
MH  - Certification
MH  - Expert Testimony
MH  - Forensic Psychiatry/*education
MH  - Humans
MH  - Psychology/*education
MH  - Teaching
EDAT- 2012/10/03 06:00
MHDA- 2013/05/28 06:00
CRDT- 2012/10/03 06:00
PHST- 2012/10/03 06:00 [entrez]
PHST- 2012/10/03 06:00 [pubmed]
PHST- 2013/05/28 06:00 [medline]
AID - S0160-2527(12)00073-8 [pii]
AID - 10.1016/j.ijlp.2012.09.010 [doi]
PST - ppublish
SO  - Int J Law Psychiatry. 2012 Sep-Dec;35(5-6):343-7. doi:
      10.1016/j.ijlp.2012.09.010. Epub 2012 Sep 28.


PMID- 23025921
OWN - NLM
STAT- MEDLINE
DCOM- 20150409
LR  - 20140818
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 28
IP  - 7
DP  - 2014 Sep
TI  - End-of-life decisions and the reinvented Rule of Double Effect: a critical
      analysis.
PG  - 368-77
LID - 10.1111/bioe.12001 [doi]
AB  - The Rule of Double Effect (RDE) holds that it may be permissible to harm an
      individual while acting for the sake of a proportionate good, given that the harm
      is not an intended means to the good but merely a foreseen side-effect. Although 
      frequently used in medical ethical reasoning, the rule has been repeatedly
      questioned in the past few decades. However, Daniel Sulmasy, a proponent who has 
      done a lot of work lately defending the RDE, has recently presented a
      reformulated and more detailed version of the rule. Thanks to its greater
      precision, this reinvented RDE avoids several problems thought to plague the
      traditional RDE. Although an improvement compared with the traditional version,
      we argue that Sulmasy's reinvented RDE will not stand closer scrutiny. Not only
      has the range of proper applicability narrowed significantly, but, more
      importantly, Sulmasy fails to establish that there is a morally relevant
      distinction between intended and foreseen effects. In particular, he fails to
      establish that there is any distinction that can account for the alleged moral
      difference between sedation therapy and euthanasia.
CI  - (c) 2012 John Wiley & Sons Ltd.
FAU - Lindblad, Anna
AU  - Lindblad A
FAU - Lynoe, Niels
AU  - Lynoe N
FAU - Juth, Niklas
AU  - Juth N
LA  - eng
PT  - Journal Article
DEP - 20121001
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
RN  - 0 (Hypnotics and Sedatives)
SB  - IM
MH  - *Decision Making
MH  - *Double Effect Principle
MH  - Ethics, Medical
MH  - Euthanasia, Active/*ethics
MH  - Euthanasia, Passive/*ethics
MH  - Humans
MH  - Hypnotics and Sedatives/adverse effects/*therapeutic use
MH  - Intention
MH  - Life
MH  - *Morals
MH  - Palliative Care/*ethics
MH  - Terminal Care/ethics
OTO - NOTNLM
OT  - double effect
OT  - end-of-life
OT  - euthanasia
OT  - pain relief
OT  - sedation therapy
OT  - utilitarianism
EDAT- 2012/10/03 06:00
MHDA- 2015/04/10 06:00
CRDT- 2012/10/03 06:00
PHST- 2012/10/03 06:00 [entrez]
PHST- 2012/10/03 06:00 [pubmed]
PHST- 2015/04/10 06:00 [medline]
AID - 10.1111/bioe.12001 [doi]
PST - ppublish
SO  - Bioethics. 2014 Sep;28(7):368-77. doi: 10.1111/bioe.12001. Epub 2012 Oct 1.


PMID- 23025906
OWN - NLM
STAT- MEDLINE
DCOM- 20150925
LR  - 20220316
IS  - 1532-2793 (Electronic)
IS  - 0260-6917 (Linking)
VI  - 33
IP  - 10
DP  - 2013 Oct
TI  - Instructor comfort level in high-fidelity simulation.
PG  - 1242-5
LID - 10.1016/j.nedt.2012.09.003 [doi]
LID - S0260-6917(12)00285-7 [pii]
AB  - BACKGROUND: The literature in the use of simulation in nursing education has
      expanded significantly over the past 5-10 years. What it is like as an instructor
      who facilitates this experience is largely unexplored. This paper is part of a
      larger ethnographic study, and represents findings related to the comfort level
      of instructors facilitating in high-fidelity simulation (HFS). OBJECTIVES: The
      question of what is it like to engage in simulated clinical experiences as an
      instructor is presented in this paper. DESIGN AND PARTICIPANTS: Twenty
      instructors participated in two separate focus groups and two instructors
      participated in individual interviews. The average years of nursing experience
      for this group was over 20 years, whereas the number of years of experience as a 
      clinical instructor was less than five years. METHODS: Ethical approval was
      obtained from two academic institutions. A focused ethnography was conducted and 
      included two terms of participant observations, recorded field notes, individual 
      interviews and focus groups. Data was coded and then sorted for themes related to
      the instructor experience. RESULTS: The primary results focus on the comfort
      level of instructors in HFS, and what instructors believe this meant to student
      learning in HFS. CONCLUSIONS: What the instructor does during HFS and how they
      feel about their ability to facilitate HFS has a perceived effect on student
      learning.
CI  - Crown Copyright (c) 2012. Published by Elsevier Ltd. All rights reserved.
FAU - Harder, B Nicole
AU  - Harder BN
AD  - Simulation Learning Centre, Faculty of Nursing, University of Manitoba, 89 Curry 
      Place, Winnipeg, Manitoba, Canada R3T 2N2. Electronic address:
      Nicole_Harder@umanitoba.ca.
FAU - Ross, Carolyn J M
AU  - Ross CJ
FAU - Paul, Pauline
AU  - Paul P
LA  - eng
PT  - Journal Article
DEP - 20120929
PL  - Scotland
TA  - Nurse Educ Today
JT  - Nurse education today
JID - 8511379
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Clinical Competence
MH  - Education, Nursing, Baccalaureate/*methods
MH  - *Faculty, Nursing
MH  - Female
MH  - Focus Groups
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - *Manikins
MH  - Middle Aged
OTO - NOTNLM
OT  - Comfort level
OT  - High-fidelity simulation
OT  - Instructor confidence
EDAT- 2012/10/03 06:00
MHDA- 2015/09/26 06:00
CRDT- 2012/10/03 06:00
PHST- 2012/01/20 00:00 [received]
PHST- 2012/09/05 00:00 [revised]
PHST- 2012/09/10 00:00 [accepted]
PHST- 2012/10/03 06:00 [entrez]
PHST- 2012/10/03 06:00 [pubmed]
PHST- 2015/09/26 06:00 [medline]
AID - S0260-6917(12)00285-7 [pii]
AID - 10.1016/j.nedt.2012.09.003 [doi]
PST - ppublish
SO  - Nurse Educ Today. 2013 Oct;33(10):1242-5. doi: 10.1016/j.nedt.2012.09.003. Epub
      2012 Sep 29.


PMID- 23025813
OWN - NLM
STAT- MEDLINE
DCOM- 20141222
LR  - 20191210
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 14
IP  - 1
DP  - 2014 Apr
TI  - Guest authors in an Iranian journal.
PG  - 15-9
LID - 10.1111/dewb.12002 [doi]
AB  - BACKGROUND: Although most biomedical journals have adopted the authorship
      criteria established by the International Committee of Medical Journal Editors
      (ICMJE) in 1985, little is known about the extent Iranian researchers are
      familiar with these criteria. OBJECTIVES: The study seeks to evaluate the number 
      of authors fulfilling ICMJE authorship criteria (considering the names mentioned 
      in the byline of 12 issues of the Archives of Iranian Medicine (AIM) journal),
      and to determine the type of contribution made by each author. MATERIALS AND
      METHODS: The fulfilment of authorship criteria and contribution percentage of
      each researcher were evaluated according to their position in the bylines of 12
      issues of the Archives of Iranian Medicine (AIM) journal published from January
      2005 to October 2007. We asked corresponding authors to answer our questionnaire 
      which was designed to assess authorship criteria and contribution. RESULTS: A
      total of 576 researchers' names were in the studied article bylines. The ratio of
      authors to articles was 3.48 in 2005, 4.06 in 2006, and 5.59 in 2007. Sixty three
      out of 128 corresponding authors (49.21%) responded to our questionnaire, so we
      evaluated 296 researchers' names, from which 186 authors (62.83%) met the
      authorship criteria; 110 authors (37.17%) were identified as guest authors, 97 of
      which deserved to be mentioned in the acknowledgement section. The major criteria
      used for authors order was their participation in research projects in addition
      to article writing, mostly determined by the corresponding author. Two authors
      (0.67%) whose names were not mentioned in the articles were considered to be
      ghost writers as the articles were based on the results of their thesis.
      CONCLUSION: It is essential to make Iranian researchers familiar with ICMJE
      authorship criteria and to encourage applying the criteria in scientific writing.
CI  - (c) 2012 John Wiley & Sons Ltd.
FAU - Ghajarzadeh, Mahsa
AU  - Ghajarzadeh M
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20121001
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
SB  - IM
MH  - *Authorship/standards
MH  - *Ethics, Research
MH  - Humans
MH  - Internationality
MH  - Iran
MH  - Periodicals as Topic/*ethics/standards
MH  - Publishing/ethics/standards/statistics & numerical data
MH  - *Research Personnel/ethics/standards/statistics & numerical data
MH  - Surveys and Questionnaires
MH  - Writing
OTO - NOTNLM
OT  - AIM
OT  - Authorship
OT  - Ethics
OT  - ICMJE
OT  - Research Ethics
EDAT- 2012/10/03 06:00
MHDA- 2014/12/23 06:00
CRDT- 2012/10/03 06:00
PHST- 2012/10/03 06:00 [entrez]
PHST- 2012/10/03 06:00 [pubmed]
PHST- 2014/12/23 06:00 [medline]
AID - 10.1111/dewb.12002 [doi]
PST - ppublish
SO  - Dev World Bioeth. 2014 Apr;14(1):15-9. doi: 10.1111/dewb.12002. Epub 2012 Oct 1.


PMID- 23025791
OWN - NLM
STAT- MEDLINE
DCOM- 20151204
LR  - 20141031
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 14
IP  - 3
DP  - 2014 Dec
TI  - Developing ethical awareness in global health: four cases for medical educators.
PG  - 111-6
LID - 10.1111/dewb.12000 [doi]
AB  - In recent years, the growth of interest in global health among medical students
      and residents has led to an abundance of short-term training opportunities in
      low-resource environments. Given the disparities in resources, needs and
      expectations between visitors and their hosts, these experiences can raise
      complex ethical concerns. Recent calls for best practices and ethical guidelines 
      indicate a need for the development of ethical awareness among medical trainees, 
      their sponsoring and host institutions, and supervising faculty. As a teaching
      tool to promote this awareness, we developed a scenario that captures many common
      ethical issues from four different perspectives. Each perspective is presented in
      case format followed by questions. Taken together, the four cases may be used to 
      identify many of the elements of a well-designed global health training
      experience.
CI  - (c) 2012 John Wiley & Sons Ltd.
FAU - White, Mary
AU  - White M
FAU - Evert, Jessica
AU  - Evert J
LA  - eng
PT  - Journal Article
DEP - 20121001
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
SB  - IM
MH  - Biomedical Research
MH  - Conflict of Interest
MH  - *Cultural Characteristics
MH  - Curriculum
MH  - Developing Countries
MH  - Education, Medical/*organization & administration/trends
MH  - Faculty, Medical
MH  - *Global Health
MH  - *Health Services Needs and Demand
MH  - Hospitals, General
MH  - Humans
MH  - *International Cooperation
MH  - Kenya
MH  - *Social Values
MH  - Students, Medical
MH  - Students, Nursing
OTO - NOTNLM
OT  - Education
OT  - developing world bioethics
OT  - medical ethics
OT  - research ethics
EDAT- 2012/10/03 06:00
MHDA- 2015/12/15 06:00
CRDT- 2012/10/03 06:00
PHST- 2012/10/03 06:00 [entrez]
PHST- 2012/10/03 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - 10.1111/dewb.12000 [doi]
PST - ppublish
SO  - Dev World Bioeth. 2014 Dec;14(3):111-6. doi: 10.1111/dewb.12000. Epub 2012 Oct 1.


PMID- 23025760
OWN - NLM
STAT- MEDLINE
DCOM- 20130314
LR  - 20151119
IS  - 1476-4954 (Electronic)
IS  - 1476-4954 (Linking)
VI  - 25
IP  - Suppl 5
DP  - 2012 Oct
TI  - Universal screening for inherited metabolic diseases in the neonate (and the
      fetus).
PG  - 4-6
LID - 10.3109/14767058.2012.716983 [doi]
AB  - The traditional focus of newborn screening for inherited metabolic diseases is to
      test infants for medical conditions that may cause significant morbidity and
      mortality unless treatment is initiated early. A major change began with the
      application of tandem mass spectrometry to the quantitative analysis of amino
      acids and acylcarnitines in dried blood spots. Beyond the lack of a consensus on 
      disease selection, the pace of introduction for expanded screening programs has
      been slow and patchy among and within countries. Universal metabolic screening
      poses important ethical issues, related to possible ambiguous findings,
      late-onset diseases, conditions, such as lysosomal storage disorders, with no
      clear-cut evidence on when and how to start a therapy. The possible application
      of next generation sequencing to newborn screening has been recently proposed. In
      the near future it will be also possible to perform a genetic and mutational scan
      across the whole genome of the fetus in a non-invasive manner by analyzing
      cell-free fetal DNA in maternal blood as early as the 5th week of gestational
      age. These high-throughput methods applied to neonatal and non-invasive prenatal 
      screening of genetic diseases, including inborn errors of metabolism, are raising
      further technical, political and ethical issues.
FAU - Scala, Iris
AU  - Scala I
AD  - Department of Pediatrics, Federico II University, Naples, Italy.
FAU - Parenti, Giancarlo
AU  - Parenti G
FAU - Andria, Generoso
AU  - Andria G
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Matern Fetal Neonatal Med
JT  - The journal of maternal-fetal & neonatal medicine : the official journal of the
      European Association of Perinatal Medicine, the Federation of Asia and Oceania
      Perinatal Societies, the International Society of Perinatal Obstetricians
JID - 101136916
RN  - 0 (Amino Acids)
RN  - 0 (acylcarnitine)
RN  - 9007-49-2 (DNA)
RN  - EC 1.3.8.7 (Acyl-CoA Dehydrogenase)
RN  - S7UI8SM58A (Carnitine)
SB  - IM
MH  - Acyl-CoA Dehydrogenase/deficiency
MH  - Amino Acids/blood
MH  - Carnitine/analogs & derivatives/blood
MH  - DNA/blood
MH  - DNA Mutational Analysis
MH  - Female
MH  - Gestational Age
MH  - Humans
MH  - Infant, Newborn
MH  - Metabolism, Inborn Errors/*diagnosis/genetics
MH  - *Neonatal Screening/ethics/methods
MH  - Paper
MH  - Phenylketonurias/blood
MH  - Pregnancy
MH  - *Prenatal Diagnosis
MH  - Tandem Mass Spectrometry
EDAT- 2012/10/03 06:00
MHDA- 2013/03/15 06:00
CRDT- 2012/10/03 06:00
PHST- 2012/10/03 06:00 [entrez]
PHST- 2012/10/03 06:00 [pubmed]
PHST- 2013/03/15 06:00 [medline]
AID - 10.3109/14767058.2012.716983 [doi]
PST - ppublish
SO  - J Matern Fetal Neonatal Med. 2012 Oct;25(Suppl 5):4-6. doi:
      10.3109/14767058.2012.716983.


PMID- 23025747
OWN - NLM
STAT- MEDLINE
DCOM- 20131125
LR  - 20130115
IS  - 1935-990X (Electronic)
IS  - 0003-066X (Linking)
VI  - 68
IP  - 1
DP  - 2013 Jan
TI  - Specialty guidelines for forensic psychology.
PG  - 7-19
LID - 10.1037/a0029889 [doi]
AB  - In the past 50 years forensic psychological practice has expanded dramatically.
      Because the practice of forensic psychology differs in important ways from more
      traditional practice areas (Monahan, 1980) the "Specialty Guidelines for Forensic
      Psychologists" were developed and published in 1991 (Committee on Ethical
      Guidelines for Forensic Psychologists, 1991). These Specialty Guidelines for
      Forensic Psychology were developed by the American Psychology-Law Society
      (Division 41 of the American Psychological Association [APA]) and the American
      Academy of Forensic Psychology. They were adopted by the APA Council of
      Representatives on August 3, 2011.
CN  - American Psychological Association
LA  - eng
PT  - Journal Article
PT  - Practice Guideline
DEP - 20121001
PL  - United States
TA  - Am Psychol
JT  - The American psychologist
JID - 0370521
SB  - IM
MH  - Communication
MH  - Conflict of Interest
MH  - Expert Testimony
MH  - Forensic Psychiatry/*standards
MH  - Humans
MH  - Societies, Scientific
EDAT- 2012/10/03 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/10/03 06:00
PHST- 2012/10/03 06:00 [entrez]
PHST- 2012/10/03 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 2012-26229-001 [pii]
AID - 10.1037/a0029889 [doi]
PST - ppublish
SO  - Am Psychol. 2013 Jan;68(1):7-19. doi: 10.1037/a0029889. Epub 2012 Oct 1.


PMID- 23025746
OWN - NLM
STAT- MEDLINE
DCOM- 20131125
LR  - 20130115
IS  - 1935-990X (Electronic)
IS  - 0003-066X (Linking)
VI  - 68
IP  - 1
DP  - 2013 Jan
TI  - Guidelines for psychological evaluations in child protection matters.
PG  - 20-31
LID - 10.1037/a0029891 [doi]
AB  - The problems of abused and neglected children are epidemic in our society (U.S.
      Department of Health and Human Services, Administration on Children, Youth, and
      Families, 2008) and create issues that psychologists may be called upon to
      address. Psychologists are positioned to contribute significantly to decision
      making in child protection matters. Psychological data and expertise may provide 
      sources of information and a perspective not otherwise available to courts
      regarding the functioning of parties, and thus may increase the fairness of
      decisions by the court, state agency, or other party. such matters. These
      guidelines are a revision of the 1999 "Guidelines for Psychological Evaluations
      in Child Protection Matters" (American Psychological Association [APA], 1999).
      These guidelines are informed by APA's "Ethical Principles of Psychologists and
      Code of Conduct" ("APA Ethics Code"; APA, 2002a, 2010).
CN  - American Psychological Association
LA  - eng
PT  - Journal Article
PT  - Practice Guideline
DEP - 20121001
PL  - United States
TA  - Am Psychol
JT  - The American psychologist
JID - 0370521
SB  - IM
MH  - Child
MH  - *Child Welfare
MH  - Human Rights
MH  - Humans
MH  - Mental Disorders/*diagnosis
EDAT- 2012/10/03 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/10/03 06:00
PHST- 2012/10/03 06:00 [entrez]
PHST- 2012/10/03 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 2012-26231-001 [pii]
AID - 10.1037/a0029891 [doi]
PST - ppublish
SO  - Am Psychol. 2013 Jan;68(1):20-31. doi: 10.1037/a0029891. Epub 2012 Oct 1.


PMID- 23025348
OWN - NLM
STAT- MEDLINE
DCOM- 20150409
LR  - 20140818
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 28
IP  - 7
DP  - 2014 Sep
TI  - In defense of prenatal genetic interventions.
PG  - 335-42
LID - 10.1111/j.1467-8519.2012.02009.x [doi]
AB  - Jurgen Habermas has argued against prenatal genetic interventions used to
      influence traits on the grounds that only biogenetic contingency in the
      conception of children preserves the conditions that make the presumption of
      moral equality possible. This argument fails for a number of reasons. The
      contingency that Habermas points to as the condition of moral equality is an
      artifact of evolutionary contingency and not inviolable in itself. Moreover, as a
      precedent for genetic interventions, parents and society already affect
      children's traits, which is to say there is moral precedent for influencing the
      traits of descendants. A veil-of-ignorance methodology can also be used to
      justify prenatal interventions through its method of advance consent and its
      preservation of the contingency of human identities in a moral sense. In any
      case, the selection of children's traits does not undermine the prospects of
      authoring a life since their future remains just as contingent morally as if no
      trait had been selected. Ironically, the prospect of preserving human beings as
      they are--to counteract genetic drift--might even require interventions to
      preserve the ability to author a life in a moral sense. In light of these
      analyses, Habermas' concerns about prenatal genetic interventions cannot succeed 
      as objections to their practice as a matter of principle; the merits of these
      interventions must be evaluated individually.
CI  - (c) 2012 John Wiley & Sons Ltd.
FAU - Murphy, Timothy F
AU  - Murphy TF
LA  - eng
PT  - Journal Article
DEP - 20121001
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Child
MH  - *Eugenics
MH  - Fertilization
MH  - Genetic Drift
MH  - Genetic Engineering/*ethics
MH  - Genetics, Population
MH  - Humans
MH  - Life
MH  - *Morals
MH  - *Parents
MH  - Reproductive Behavior/*ethics
OTO - NOTNLM
OT  - ethics
OT  - eugenics
OT  - genetic interventions
OT  - prenatal testing
OT  - sex selection
EDAT- 2012/10/03 06:00
MHDA- 2015/04/10 06:00
CRDT- 2012/10/03 06:00
PHST- 2012/10/03 06:00 [entrez]
PHST- 2012/10/03 06:00 [pubmed]
PHST- 2015/04/10 06:00 [medline]
AID - 10.1111/j.1467-8519.2012.02009.x [doi]
PST - ppublish
SO  - Bioethics. 2014 Sep;28(7):335-42. doi: 10.1111/j.1467-8519.2012.02009.x. Epub
      2012 Oct 1.


PMID- 23025329
OWN - NLM
STAT- MEDLINE
DCOM- 20151002
LR  - 20140915
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 28
IP  - 8
DP  - 2014 Oct
TI  - Randomized controlled trials of maternal-fetal surgery: a challenge to clinical
      equipoise.
PG  - 405-13
LID - 10.1111/j.1467-8519.2012.02008.x [doi]
AB  - This article focuses on maternal-fetal surgery (MFS) and on the concept of
      clinical equipoise that is a widely accepted requirement for conducting
      randomized controlled trials (RCT). There are at least three reasons why
      equipoise is unsuitable for MFS. First, the concept is based on a misconception
      about the nature of clinical research and the status of research subjects.
      Second, given that it is not clear who the research subject/s in MFS is/are, if
      clinical equipoise is to be used as a criterion to test the ethical
      appropriateness of RCT, its meaning should be unambiguous. Third, because of the 
      multidisciplinary character of MFS, it is not clear who should be in equipoise.
      As a result, we lack an adequate criterion for the ethical review of MFS
      protocols. In our account, which is based on Chervenak and McCullough's seminal
      work in the field of obstetric ethics, equipoise is abandoned. and RCT involving 
      MFS can be ethically initiated when a multidisciplinary ethics review board
      (ERB), having an evidence-based assessment of the risks involved, is convinced
      that the value of answering the research hypothesis, for the sake of the health
      interests of future pregnant women carrying fetuses with certain congenital birth
      defects, justifies the actual risks research participants might suffer within a
      set limit of low/manageable.
CI  - (c) 2012 John Wiley & Sons Ltd.
FAU - Rodrigues, H C M L
AU  - Rodrigues HC
AD  - University Medical Center Groningen, Department of Obstetrics and Gynecology, The
      Netherlands Medical faculty of the University of Groningen in the Netherlands and
      University Medical Center Groningen.
FAU - van den Berg, P P
AU  - van den Berg PP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121001
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Congenital Abnormalities/*prevention & control/*surgery
MH  - Ethical Analysis
MH  - Evidence-Based Medicine
MH  - Female
MH  - Fetus/*surgery
MH  - Humans
MH  - Interdisciplinary Communication
MH  - *Moral Obligations
MH  - Observer Variation
MH  - Patient Care Team
MH  - Personhood
MH  - Pregnancy
MH  - *Pregnant Women
MH  - Randomized Controlled Trials as Topic/*ethics/standards
MH  - *Research Subjects
MH  - *Therapeutic Equipoise
OTO - NOTNLM
OT  - equipoise
OT  - ethical review
OT  - maternal-fetal surgery
OT  - randomized controlled trials
EDAT- 2012/10/03 06:00
MHDA- 2015/10/03 06:00
CRDT- 2012/10/03 06:00
PHST- 2012/10/03 06:00 [entrez]
PHST- 2012/10/03 06:00 [pubmed]
PHST- 2015/10/03 06:00 [medline]
AID - 10.1111/j.1467-8519.2012.02008.x [doi]
PST - ppublish
SO  - Bioethics. 2014 Oct;28(8):405-13. doi: 10.1111/j.1467-8519.2012.02008.x. Epub
      2012 Oct 1.


PMID- 23025281
OWN - NLM
STAT- MEDLINE
DCOM- 20150409
LR  - 20140818
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 28
IP  - 7
DP  - 2014 Sep
TI  - Epigenetics and the environment in bioethics.
PG  - 327-34
LID - 10.1111/j.1467-8519.2012.02007.x [doi]
AB  - A rich literature in public health has demonstrated that health is strongly
      influenced by a host of environmental factors that can vary according to social, 
      economic, geographic, cultural or physical contexts. Bioethicists should, we
      argue, recognize this and--where appropriate--work to integrate environmental
      concerns into their field of study and their ethical deliberations. In this
      article, we present an argument grounded in scientific research at the molecular 
      level that will be familiar to--and so hopefully more persuasive for--the
      biomedically-inclined in the bioethics community. Specifically, we argue that the
      relatively new field of molecular epigenetics provides novel information that
      should serve as additional justification for expanding the scope of bioethics to 
      include environmental and public health concerns. We begin by presenting two
      distinct visions of bioethics: the individualistic and rights-oriented and the
      communitarian and responsibility-oriented. We follow with a description of
      biochemical characteristics distinguishing epigenetics from genetics, in order to
      emphasize the very close relationship that exists between the environment and
      gene expression. This then leads to a discussion of the importance of the
      environment in determining individual and population health, which, we argue,
      should shift bioethics towards a Potterian view that promotes a
      communitarian-based sense of responsibility for the environment, in order to
      fully account for justice considerations and improve public health.
CI  - (c) 2012 John Wiley & Sons Ltd.
FAU - Dupras, Charles
AU  - Dupras C
FAU - Ravitsky, Vardit
AU  - Ravitsky V
FAU - Williams-Jones, Bryn
AU  - Williams-Jones B
LA  - eng
PT  - Journal Article
DEP - 20121001
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - *Bioethics
MH  - Environmental Health/*ethics
MH  - *Epigenesis, Genetic
MH  - Ethical Theory
MH  - Gene Expression
MH  - Genetics/*ethics
MH  - Human Rights
MH  - Humans
MH  - Public Health/*ethics
MH  - Social Justice
MH  - *Social Responsibility
OTO - NOTNLM
OT  - bioethics
OT  - determinants of health
OT  - environment
OT  - epigenetics
OT  - public health
OT  - responsibility
EDAT- 2012/10/03 06:00
MHDA- 2015/04/10 06:00
CRDT- 2012/10/03 06:00
PHST- 2012/10/03 06:00 [entrez]
PHST- 2012/10/03 06:00 [pubmed]
PHST- 2015/04/10 06:00 [medline]
AID - 10.1111/j.1467-8519.2012.02007.x [doi]
PST - ppublish
SO  - Bioethics. 2014 Sep;28(7):327-34. doi: 10.1111/j.1467-8519.2012.02007.x. Epub
      2012 Oct 1.


PMID- 23025264
OWN - NLM
STAT- MEDLINE
DCOM- 20140317
LR  - 20211021
IS  - 1939-0599 (Electronic)
IS  - 0012-1649 (Linking)
VI  - 49
IP  - 8
DP  - 2013 Aug
TI  - The developmental significance of late adolescent substance use for early adult
      functioning.
PG  - 1554-64
LID - 10.1037/a0030229 [doi]
AB  - This study examines the predictive significance of late adolescent substance use 
      groups (i.e., abstainers, experimental users, at-risk users, and abusers) for
      early adult adaptation. Participants (N = 159) were drawn from a prospective
      longitudinal study of first-born children of low-income mothers. At 17.5 years of
      age, participants were assigned to substance use groups on the basis of their
      level of substance use involvement. At 26 years, early adult competence was
      assessed in the areas of education, work, romantic relationships, and global
      adaptation. Results indicate that 17.5-year substance use group membership
      significantly predicted high school completion, regular involvement in a
      long-term romantic relationship, good or better work ethic, and good or better
      global adjustment at 26 years when controlling for gender; IQ; 16-year
      internalizing and externalizing behavior problems, parental monitoring, and peer 
      competence; and current substance use at 26 years. Group comparisons indicate
      that late adolescent substance use experimenters were significantly more likely
      in early adulthood to have (a) a high school diploma or higher level of education
      compared with abstainers (OR = 8.83); (b) regular involvement in long-term
      romantic relationships (OR = 3.23), and good or better global adaptation (OR =
      4.08) compared with at-risk users; and (c) good or better work ethic (OR = 4.04) 
      compared with abusers. This research indicates that patterns of late adolescent
      substance use has implications for early adult functioning in salient
      developmental domains.
CI  - (PsycINFO Database Record (c) 2013 APA, all rights reserved).
FAU - Englund, Michelle M
AU  - Englund MM
AD  - Institute of Child Development, University of Minnesota, 51 East River Road,
      Minneapolis, MN 55455, USA. englu008@umn.edu
FAU - Siebenbruner, Jessica
AU  - Siebenbruner J
FAU - Oliva, Elizabeth M
AU  - Oliva EM
FAU - Egeland, Byron
AU  - Egeland B
FAU - Chung, Chu-Ting
AU  - Chung CT
FAU - Long, Jeffrey D
AU  - Long JD
LA  - eng
GR  - R01 HD054850/HD/NICHD NIH HHS/United States
GR  - R01 MH040864/MH/NIMH NIH HHS/United States
GR  - R01HD054850/HD/NICHD NIH HHS/United States
GR  - R01MH40864/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20121001
PL  - United States
TA  - Dev Psychol
JT  - Developmental psychology
JID - 0260564
SB  - IM
MH  - Adaptation, Psychological/*physiology
MH  - Adolescent
MH  - *Adolescent Behavior
MH  - Adult
MH  - Female
MH  - Human Development/*physiology
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Peer Group
MH  - Risk Factors
MH  - Social Adjustment
MH  - Social Behavior
MH  - Substance-Related Disorders/*physiopathology
MH  - Young Adult
PMC - PMC3568218
MID - NIHMS412772
EDAT- 2012/10/03 06:00
MHDA- 2014/03/19 06:00
CRDT- 2012/10/03 06:00
PHST- 2012/10/03 06:00 [entrez]
PHST- 2012/10/03 06:00 [pubmed]
PHST- 2014/03/19 06:00 [medline]
AID - 2012-26177-001 [pii]
AID - 10.1037/a0030229 [doi]
PST - ppublish
SO  - Dev Psychol. 2013 Aug;49(8):1554-64. doi: 10.1037/a0030229. Epub 2012 Oct 1.


PMID- 23025118
OWN - NLM
STAT- MEDLINE
DCOM- 20121207
LR  - 20211203
IS  - 1221-9118 (Print)
IS  - 1221-9118 (Linking)
VI  - 107
IP  - 4
DP  - 2012 Jul-Aug
TI  - Retrospective study regarding objectives and results of upper limb transplant.
PG  - 501-9
AB  - INTRODUCTION: Upper limb amputation causes a severe permanent disability. Upper
      limb transplantation is subject to treatment to prevent rejection and influenced 
      by organizational, socioeconomic, psychological, ethical factors. Analysis of the
      results creates the potential for continuing this work in specific conditions in 
      our country. MATERIAL AND METHODS: We retrospectively analyzed data from the
      literature. Upon completion of documentation (May 2011) there were 74 transplants
      in 53 patients worldwide. We have studied the available information on the
      surgical interventions and their results. RESULTS: Upper limb allograft has a
      complex structure comprising tissue with variable antigenicity. Surgery is
      performed by a large multidisciplinary team, whose increased experience leads to 
      a shorter length of the operation. The postoperative follow-up and rehabilitation
      program are standardized, and patients' compliance is essential. The greatest
      advances have occurred in immunosuppression protocols. CONCLUSION: The upper limb
      transplantation was performed in 20 centers of 12 countries so far. The
      specification of the indications and contraindications, the proper selection of
      patients, the increasing experience and new immunosuppression protocols provide a
      higher success rate and quality of functional outcome. By applying these
      conceptual acquisitions we will be able to create conditions for the integration 
      of our country in this globally convergent scientific effort.
FAU - Luculescu, P
AU  - Luculescu P
AD  - Department of Plastic Surgery and Reconstructive Microsurgery, County Emergency
      Hospital, Deva, Romania. paulaluculescu@gmail.com
FAU - Bodog, F
AU  - Bodog F
FAU - Crainiceanu, Z
AU  - Crainiceanu Z
FAU - Popa, F
AU  - Popa F
FAU - Bratu, T
AU  - Bratu T
FAU - Lascars, I
AU  - Lascars I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Romania
TA  - Chirurgia (Bucur)
JT  - Chirurgia (Bucharest, Romania : 1990)
JID - 9213031
SB  - IM
EIN - Chirurgia (Bucur). 2012 Nov-Dec;107(6):2 p following 824
EIN - Chirurgia (Bucur). 2015 Jul-Aug;110(4):401. PMID: 26394453
MH  - *Hand Transplantation
MH  - Humans
MH  - Immunosuppression Therapy/methods
MH  - Interdisciplinary Communication
MH  - Patient Selection
MH  - Recovery of Function
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Time Factors
MH  - Transplantation, Homologous
MH  - Treatment Outcome
MH  - Upper Extremity/surgery
MH  - Wound Healing
EDAT- 2012/10/03 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/10/03 06:00
PHST- 2012/10/03 06:00 [entrez]
PHST- 2012/10/03 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
PST - ppublish
SO  - Chirurgia (Bucur). 2012 Jul-Aug;107(4):501-9.


PMID- 23024381
OWN - NLM
STAT- MEDLINE
DCOM- 20121129
LR  - 20211021
IS  - 0008-5286 (Print)
IS  - 0008-5286 (Linking)
VI  - 53
IP  - 4
DP  - 2012 Apr
TI  - Veterinary medical ethics: an ethicist's commentary on veterinarians and
      pharmaceutical companies restricting access to a non-prescription product.
PG  - 346
FAU - Rollin, Bernard E
AU  - Rollin BE
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Vet J
JT  - The Canadian veterinary journal = La revue veterinaire canadienne
JID - 0004653
RN  - 0 (Prescription Drugs)
RN  - 0 (Veterinary Drugs)
SB  - IM
CIN - Can Vet J. 2012 Jul;53(7):698. PMID: 23277637
MH  - Animals
MH  - Commerce/*economics/*ethics
MH  - Income
MH  - *Prescription Drugs
MH  - Veterinarians/economics/*ethics/psychology
MH  - *Veterinary Drugs
PMC - PMC3299502
EDAT- 2012/10/02 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/10/02 06:00
PHST- 2012/10/02 06:00 [entrez]
PHST- 2012/10/02 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
PST - ppublish
SO  - Can Vet J. 2012 Apr;53(4):346.


PMID- 23024323
OWN - NLM
STAT- MEDLINE
DCOM- 20130318
LR  - 20181202
IS  - 1399-3003 (Electronic)
IS  - 0903-1936 (Linking)
VI  - 40
IP  - 4
DP  - 2012 Oct
TI  - Euthanasia: from ethical debate to clinical reality.
PG  - 804-5
FAU - Berghmans, Thierry
AU  - Berghmans T
FAU - Lossignol, Dominique
AU  - Lossignol D
LA  - eng
PT  - Editorial
PT  - Comment
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
SB  - IM
CON - Eur Respir J. 2012 Oct;40(4):949-56. PMID: 22523361
MH  - *Carcinoma, Non-Small-Cell Lung
MH  - Euthanasia/*statistics & numerical data
MH  - Female
MH  - Humans
MH  - *Lung Neoplasms
MH  - Male
MH  - Patient Preference/*statistics & numerical data
MH  - Practice Patterns, Physicians'/*statistics & numerical data
EDAT- 2012/10/02 06:00
MHDA- 2013/03/19 06:00
CRDT- 2012/10/02 06:00
PHST- 2012/10/02 06:00 [entrez]
PHST- 2012/10/02 06:00 [pubmed]
PHST- 2013/03/19 06:00 [medline]
AID - 40/4/804 [pii]
AID - 10.1183/09031936.00039112 [doi]
PST - ppublish
SO  - Eur Respir J. 2012 Oct;40(4):804-5. doi: 10.1183/09031936.00039112.


PMID- 23024305
OWN - NLM
STAT- MEDLINE
DCOM- 20131017
LR  - 20190709
IS  - 1943-4723 (Electronic)
IS  - 0002-8177 (Linking)
VI  - 143
IP  - 10
DP  - 2012 Oct
TI  - Mandatory reporting of oral injuries indicating possible child abuse.
PG  - 1087-92
AB  - BACKGROUND: The dental professional may see pediatric patients who have signs of 
      intraoral trauma, perioral trauma or both. Evaluation should include the
      possibility of nonaccidental, deliberately inflicted abuse. Reporting such
      injuries is mandated. METHODS: The authors reviewed the criminal and civil
      statutes in all 50 states to determine what role dental professionals are
      required to play in instances of abuse or neglect. RESULTS: Mandates in all 50
      states require that dental professionals be aware of and report instances of
      child abuse and neglect to the proper state authority. State laws also protect
      the reporting dental professional from civil retribution. CONCLUSIONS: State laws
      and dental ethical duties require all dental professionals to be aware of and to 
      report instances of child abuse or neglect. These same laws protect clinicians in
      this duty. It is the clinician's responsibility to help prevent ongoing injury to
      people who are incapable of self-protection. CLINICAL IMPLICATIONS: Clinicians
      should learn to recognize signs of abuse and neglect, which often involve injury 
      to the mouth and dentition. Dental professionals are mandated to report such
      abuse to state child protection authorities.
FAU - Katner, David R
AU  - Katner DR
AD  - Tulane Juvenile Law Clinic, Tulane Law School, Tulane University, New Orleans,
      LA, USA.
FAU - Brown, Christopher E
AU  - Brown CE
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Am Dent Assoc
JT  - Journal of the American Dental Association (1939)
JID - 7503060
SB  - IM
MH  - Child
MH  - Child Abuse/diagnosis/*legislation & jurisprudence
MH  - Dentists/*legislation & jurisprudence
MH  - *Ethics, Dental
MH  - Humans
MH  - Liability, Legal
MH  - *Mandatory Reporting
MH  - Maxillofacial Injuries/*etiology
MH  - United States
EDAT- 2012/10/02 06:00
MHDA- 2013/10/18 06:00
CRDT- 2012/10/02 06:00
PHST- 2012/10/02 06:00 [entrez]
PHST- 2012/10/02 06:00 [pubmed]
PHST- 2013/10/18 06:00 [medline]
AID - S0002-8177(14)61169-7 [pii]
AID - 10.14219/jada.archive.2012.0038 [doi]
PST - ppublish
SO  - J Am Dent Assoc. 2012 Oct;143(10):1087-92. doi: 10.14219/jada.archive.2012.0038.


PMID- 23024239
OWN - NLM
STAT- MEDLINE
DCOM- 20130429
LR  - 20161020
IS  - 1464-3677 (Electronic)
IS  - 1353-4505 (Linking)
VI  - 24
IP  - 6
DP  - 2012 Dec
TI  - Quality of care as a determinant of health-related quality of life in
      ill-hospitalized adolescents at a tertiary care hospital in North India.
PG  - 587-94
LID - 10.1093/intqhc/mzs054 [doi]
AB  - OBJECTIVE: To evaluate if quality of care (QoC) provided by hospital is a
      determinant of ill-hospitalized adolescent's health-related quality of life
      (HRQoL) from parent's perspective. DESIGN: Prospective cross-sectional study
      conducted at a tertiary care hospital of Northern India after institutional
      ethical approval. SETTING: Hospital in pediatric department of a tertiary care,
      teaching medical University in Lucknow, northern India. PARTICIPANTS: Sick
      adolescents aged between 10 and 19 years and hospitalized for four categories of 
      illnesses, namely, acute infective; chronic infective, non-hemopoetic; hemopoetic
      disorders and miscellaneous. INTERVENTION: QOC assessment was done using 'Pyramid
      instrument' and HRQoL by culturally modified WHOQOL-BREF (World Health
      Organization Quality of Life-BREF). The Pyramid instrument comprises 43 questions
      to collect information about awareness of eight indices: namely illness,
      routines, accessibility, medical treatment, care processes, staff attitude,
      participation and staff work environment and scored on 1-4 Likert scale.
      WHOQOL-BREF has four domains: physical, psychological, social relations and
      environment and scored on 1-5 Likert scale. RESULTS: From January 2008 to
      December 2008, 300 adolescents with a mean age of 12.5 +/- 2.6 years and 61.3%
      males were included. The pyramid instrument showed a substantial internal
      consistency (alpha = 0.88, P-value < 0.0001). The mean QoC was highest for
      medical treatment (0.76 +/- 0.13) and lowest for participation (0.54 +/- 0.16).
      The mean parent's report of child's HRQoL was highest for physical (42.8 +/- 7.4)
      and lowest for environment domain (37.2 +/- 7.1). Four QoC indices namely,
      medical treatment, care processes, staff attitude and participation had
      significant associations with the mean HRQoL. In a hierarchical linear
      regression, staff attitude was the only significant determinant of HRQoL (beta
      coefficient: 23.16, 95% confidence interval: 15.8-30.5, P-value < 0.0001).
      CONCLUSION: The Pyramid instrument is a reliable instrument for assessing
      parent's perception of QoC provided to hospitalized adolescents in Indian
      context. QoC was positively associated with HRQoL, thus, an increased focus on
      QoC especially staff attitude is likely to enhance adolescent's overall HRQoL.
FAU - Awasthi, Shally
AU  - Awasthi S
AD  - Department of Pediatrics, Chattrapati Shahuji Maharaj Medical University
      (Erstwhile King George's Medical University), Shahmina Road, Lucknow, Uttar
      Pradesh 226003, India. shallya@rediffmail.com
FAU - Agnihotri, Kasturi
AU  - Agnihotri K
FAU - Thakur, Savitri
AU  - Thakur S
FAU - Singh, Uttam
AU  - Singh U
FAU - Chandra, Hem
AU  - Chandra H
LA  - eng
PT  - Journal Article
DEP - 20120928
PL  - England
TA  - Int J Qual Health Care
JT  - International journal for quality in health care : journal of the International
      Society for Quality in Health Care
JID - 9434628
SB  - IM
MH  - Adolescent
MH  - Attitude of Health Personnel
MH  - Child
MH  - Cross-Sectional Studies
MH  - Environment
MH  - Female
MH  - Health Services Accessibility
MH  - Health Services Administration
MH  - Humans
MH  - India
MH  - Male
MH  - Middle Aged
MH  - Patient Education as Topic
MH  - Patient Satisfaction
MH  - Pediatrics/*organization & administration
MH  - Perception
MH  - Prospective Studies
MH  - Psychometrics
MH  - Quality of Health Care/*organization & administration
MH  - *Quality of Life
MH  - Reproducibility of Results
MH  - Socioeconomic Factors
MH  - Tertiary Care Centers/*organization & administration
EDAT- 2012/10/02 06:00
MHDA- 2013/04/30 06:00
CRDT- 2012/10/02 06:00
PHST- 2012/10/02 06:00 [entrez]
PHST- 2012/10/02 06:00 [pubmed]
PHST- 2013/04/30 06:00 [medline]
AID - mzs054 [pii]
AID - 10.1093/intqhc/mzs054 [doi]
PST - ppublish
SO  - Int J Qual Health Care. 2012 Dec;24(6):587-94. doi: 10.1093/intqhc/mzs054. Epub
      2012 Sep 28.


PMID- 23023964
OWN - NLM
STAT- MEDLINE
DCOM- 20130211
LR  - 20220410
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 265
IP  - 3
DP  - 2012 Dec
TI  - Iodinated contrast media differentially affect afferent and efferent arteriolar
      tone and reactivity in mice: a possible explanation for reduced glomerular
      filtration rate.
PG  - 762-71
LID - 10.1148/radiol.12120044 [doi]
AB  - PURPOSE: To determine the effect of the iodinated contrast medium iodixanol on
      arteriolar tone in afferent and efferent arterioles of the glomerulus and the
      functional interactions with the major modulators of arteriolar tone, angiotensin
      II and nitric oxide, in mice. MATERIALS AND METHODS: Animal handling conformed to
      the ethics guidelines of the Office for Health and Social Matters of Berlin.
      Arterioles were isolated from 136 C57BL/6 mice, perfused with either vehicle
      solution or iodixanol (23 mg of iodine per milliliter) for 20 minutes, followed
      by angiotensin II administration. Fluorescence of
      3-amino-4-(N-methylamino)-2',7'-difluorofluorescein (DAF-FM) and dihydroethidium 
      (DHE) were used for quantification of nitric oxide bioavailability and superoxide
      concentration, respectively. Statistical analysis of time- and dose-dependent
      data was performed by using the nonparametric test for repeated measurements.
      RESULTS: With iodixanol, afferent arteriole diameters were significantly reduced 
      from 9.2 microm to 8.3 microm; in control group, the diameters were increased
      from 8.7 microm to 9.3 microm (P = .008). Nitric oxide synthase inhibition
      augmented iodixanol-induced constriction, with diameters reduced from 9.9 microm 
      to 5.8 microm (P < .0001). DAF-FM fluorescence increased less during iodixanol
      treatment and nitric oxide synthase inhibition (3.6% and 3.7% vs 10.7% in control
      group, P = .009 and P = .049, respectively), indicating impaired nitric oxide
      bioavailability. With iodixanol, DHE fluorescence ratio was increased by 12% (P <
      .0001). Angiotensin II responses were enhanced by iodixanol and by nitric oxide
      synthase inhibition after perfusion with iodixanol (3.3 microm and 4.3 microm vs 
      7.5 microm [control group] with 1 x 10(-6)/mol/L angiotensin II, P = .03 for
      both). In contrast, in efferent arterioles, neither their basal diameters nor the
      responses to angiotensin II were significantly affected by iodixanol. CONCLUSION:
      A more pronounced effect of iodixanol on afferent than on efferent arterioles may
      contribute to the reduction of glomerular filtration rate in contrast
      medium-induced acute kidney injury. Decreased nitric oxide bioavailability and
      increased concentration of superoxide explain the increased tone and reactivity
      in afferent arterioles perfused with iodixanol.
CI  - (c) RSNA, 2012.
FAU - Liu, Zhi Z
AU  - Liu ZZ
AD  - Institute of Vegetative Physiology, Charite-Universitatsmedizin Berlin, Hessische
      Strasse 3-4, 10115 Berlin, Germany.
FAU - Viegas, Vinicius U
AU  - Viegas VU
FAU - Perlewitz, Andrea
AU  - Perlewitz A
FAU - Lai, En Y
AU  - Lai EY
FAU - Persson, Pontus B
AU  - Persson PB
FAU - Patzak, Andreas
AU  - Patzak A
FAU - Sendeski, Mauricio M
AU  - Sendeski MM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120927
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (3-amino-4-monomethylamino-2',7'-difluorofluorecein)
RN  - 0 (Contrast Media)
RN  - 0 (Cyclic N-Oxides)
RN  - 0 (Ethylamines)
RN  - 0 (Fluoresceins)
RN  - 0 (Spin Labels)
RN  - 0 (Triiodobenzoic Acids)
RN  - 0 (dihydroethidine)
RN  - 11062-77-4 (Superoxides)
RN  - 11128-99-7 (Angiotensin II)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 632-93-9 (Dicarbethoxydihydrocollidine)
RN  - HW8W27HTXX (iodixanol)
RN  - U78ZX2F65X (tempol)
RN  - V55S2QJN2X (NG-Nitroarginine Methyl Ester)
SB  - IM
CIN - Radiology. 2012 Dec;265(3):651-3. PMID: 23175539
MH  - Analysis of Variance
MH  - Angiotensin II/pharmacology
MH  - Animals
MH  - Arterioles/*drug effects
MH  - Contrast Media/*pharmacology
MH  - Cyclic N-Oxides/pharmacology
MH  - Dicarbethoxydihydrocollidine/analogs & derivatives/pharmacology
MH  - Ethylamines/pharmacology
MH  - Fluoresceins/pharmacology
MH  - Glomerular Filtration Rate/*drug effects
MH  - Kidney Glomerulus/drug effects
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - NG-Nitroarginine Methyl Ester/pharmacology
MH  - Nitric Oxide/metabolism
MH  - Spin Labels
MH  - Statistics, Nonparametric
MH  - Superoxides/metabolism
MH  - Triiodobenzoic Acids/*pharmacology
MH  - Vasoconstriction/drug effects
EDAT- 2012/10/02 06:00
MHDA- 2013/02/12 06:00
CRDT- 2012/10/02 06:00
PHST- 2012/10/02 06:00 [entrez]
PHST- 2012/10/02 06:00 [pubmed]
PHST- 2013/02/12 06:00 [medline]
AID - radiol.12120044 [pii]
AID - 10.1148/radiol.12120044 [doi]
PST - ppublish
SO  - Radiology. 2012 Dec;265(3):762-71. doi: 10.1148/radiol.12120044. Epub 2012 Sep
      27.


PMID- 23023808
OWN - NLM
STAT- MEDLINE
DCOM- 20130524
LR  - 20160526
IS  - 1098-8947 (Electronic)
IS  - 0743-684X (Linking)
VI  - 28
IP  - 9
DP  - 2012 Nov
TI  - Usefulness of Harmonic Focus during anterolateral thigh flap elevation.
PG  - 615-8
LID - 10.1055/s-0032-1326739 [doi]
AB  - Meticulous hemostasis and careful ligation of branches are necessary for pedicle 
      dissection during flap elevation. The aim of this study was to evaluate the
      effectiveness of the Harmonic Focus handpiece (Ethicon Endo-Surgery, Inc., Blue
      Ash, Cincinnati, OH, USA) in reducing operation time, bleeding volume, and volume
      of postoperative drainage during anterolateral thigh flap elevation. Ten patients
      requiring flap elevation were divided into two groups: (1) Harmonic Focus group
      (three men, two women), and (2) control group (three men, two women). Operating
      time was found to be lower in the Harmonic Focus group than in the control group.
      Bleeding volume and postoperative drainage volume were nearly identical in the
      Harmonic Focus group and the control group, and the number of silk ligatures was 
      significantly lower in the Harmonic Focus group compared with the control group. 
      Although somewhat costly, the Harmonic Scalpel with the Harmonic Focus handpiece 
      is advantageous for flap elevation, and it is likely that Harmonic Scalpel use
      will increase in plastic surgery.
CI  - Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
FAU - Hamahata, Atsumori
AU  - Hamahata A
AD  - Department of Plastic and Reconstructive Surgery, Tokyo Women's Medical
      University, Tokyo, Japan. a.hamahata@gmail.com
FAU - Saitou, Takashi
AU  - Saitou T
FAU - Kubo, Kazuyuki
AU  - Kubo K
FAU - Beppu, Takeshi
AU  - Beppu T
FAU - Yamaki, Takashi
AU  - Yamaki T
FAU - Sakurai, Hiroyuki
AU  - Sakurai H
LA  - eng
PT  - Journal Article
DEP - 20120921
PL  - United States
TA  - J Reconstr Microsurg
JT  - Journal of reconstructive microsurgery
JID - 8502670
SB  - IM
MH  - Blood Loss, Surgical/prevention & control
MH  - Case-Control Studies
MH  - Drainage
MH  - Female
MH  - Head and Neck Neoplasms/*surgery
MH  - Hemostasis, Surgical/*instrumentation
MH  - Humans
MH  - Ligation
MH  - Male
MH  - Middle Aged
MH  - Operative Time
MH  - Postoperative Complications/prevention & control
MH  - Reconstructive Surgical Procedures/*instrumentation
MH  - Surgical Flaps/*blood supply
MH  - *Surgical Instruments
MH  - Thigh/*blood supply
MH  - Treatment Outcome
MH  - Ultrasonics/*instrumentation
EDAT- 2012/10/02 06:00
MHDA- 2013/05/28 06:00
CRDT- 2012/10/02 06:00
PHST- 2012/10/02 06:00 [entrez]
PHST- 2012/10/02 06:00 [pubmed]
PHST- 2013/05/28 06:00 [medline]
AID - 10.1055/s-0032-1326739 [doi]
PST - ppublish
SO  - J Reconstr Microsurg. 2012 Nov;28(9):615-8. doi: 10.1055/s-0032-1326739. Epub
      2012 Sep 21.


PMID- 23023491
OWN - NLM
STAT- MEDLINE
DCOM- 20121130
LR  - 20121001
IS  - 2042-7670 (Electronic)
IS  - 0042-4900 (Linking)
VI  - 171
IP  - 13
DP  - 2012 Sep 29
TI  - Ethics of firing debated at BEVA congress.
PG  - 312-4
FAU - Harris, Gill
AU  - Harris G
LA  - eng
PT  - News
PL  - England
TA  - Vet Rec
JT  - The Veterinary record
JID - 0031164
SB  - IM
MH  - Animal Welfare/*ethics
MH  - Animals
MH  - *Congresses as Topic
MH  - *Horses
MH  - Humans
MH  - Pain/epidemiology/prevention & control/*veterinary
MH  - Tendon Injuries/*veterinary
MH  - Veterinary Medicine/*ethics
EDAT- 2012/10/02 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/10/02 06:00
PHST- 2012/10/02 06:00 [entrez]
PHST- 2012/10/02 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - vr.e6500 [pii]
AID - 10.1136/vr.e6500 [doi]
PST - ppublish
SO  - Vet Rec. 2012 Sep 29;171(13):312-4. doi: 10.1136/vr.e6500.


PMID- 23022585
OWN - NLM
STAT- MEDLINE
DCOM- 20130826
LR  - 20130313
IS  - 1879-2499 (Electronic)
IS  - 1369-8486 (Linking)
VI  - 44
IP  - 1
DP  - 2013 Mar
TI  - Renegotiating forensic cultures: between law, science and criminal justice.
PG  - 47-59
LID - 10.1016/j.shpsc.2012.09.010 [doi]
LID - S1369-8486(12)00104-5 [pii]
AB  - This article challenges stereotypical conceptions of Law and Science as cultural 
      opposites, arguing that English criminal trial practice is fundamentally
      congruent with modern science's basic epistemological assumptions, values and
      methods of inquiry. Although practical tensions undeniably exist, they are
      explicable-and may be neutralised-by paying closer attention to criminal
      adjudication's normative ideals and their institutional expression in familiar
      aspects of common law trial procedure, including evidentiary rules of
      admissibility, trial by jury, adversarial fact-finding, cross-examination and the
      ethical duties of expert witnesses. Effective partnerships between lawyers and
      forensic scientists are indispensable for integrating scientific evidence into
      criminal proceedings, and must be renegotiated between individual practitioners
      on an on-going basis. Fruitful interdisciplinary collaboration between scholars
      with a shared interest in forensic science should dispense with reductive
      cultural stereotypes of Science and Law.
CI  - Copyright (c) 2013. Published by Elsevier Ltd.
FAU - Roberts, Paul
AU  - Roberts P
AD  - School of Law, University of Nottingham, Nottingham, UK.
      paul.roberts@nottingham.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20120928
PL  - England
TA  - Stud Hist Philos Biol Biomed Sci
JT  - Studies in history and philosophy of biological and biomedical sciences
JID - 9810965
SB  - IM
MH  - Cooperative Behavior
MH  - Crime/*legislation & jurisprudence
MH  - *Criminal Law
MH  - *Culture
MH  - England
MH  - Expert Testimony
MH  - Forensic Sciences/*legislation & jurisprudence
MH  - Humans
MH  - Knowledge
MH  - *Science
EDAT- 2012/10/02 06:00
MHDA- 2013/08/27 06:00
CRDT- 2012/10/02 06:00
PHST- 2012/10/02 06:00 [entrez]
PHST- 2012/10/02 06:00 [pubmed]
PHST- 2013/08/27 06:00 [medline]
AID - S1369-8486(12)00104-5 [pii]
AID - 10.1016/j.shpsc.2012.09.010 [doi]
PST - ppublish
SO  - Stud Hist Philos Biol Biomed Sci. 2013 Mar;44(1):47-59. doi:
      10.1016/j.shpsc.2012.09.010. Epub 2012 Sep 28.


PMID- 23022402
OWN - NLM
STAT- MEDLINE
DCOM- 20130417
LR  - 20211021
IS  - 1872-8278 (Electronic)
IS  - 1567-7249 (Linking)
VI  - 12
IP  - 6
DP  - 2012 Nov
TI  - Design and implementation of the first randomized controlled trial of coenzyme
      CoQ(1)(0) in children with primary mitochondrial diseases.
PG  - 623-9
LID - 10.1016/j.mito.2012.09.005 [doi]
LID - S1567-7249(12)00220-6 [pii]
AB  - We report the design and implementation of the first phase 3 trial of
      CoenzymeQ(1)(0) (CoQ(1)(0)) in children with genetic mitochondrial diseases. A
      novel, rigorous set of eligibility criteria was established. The trial, which
      remains open to recruitment, continues to address multiple challenges to the
      recruitment of patients, including widely condoned empiric use of CoQ(1)(0) by
      individuals with proven or suspected mitochondrial disease and skepticism among
      professional and lay mitochondrial disease communities about participating in
      placebo-controlled trials. These attitudes represent significant barriers to the 
      ethical and scientific evaluation--and ultimate approval--of nutritional and
      pharmacological therapies for patients with life-threatening inborn errors of
      energy metabolism.
CI  - Copyright (c) 2012 Elsevier B.V. and Mitochondria Research Society. All rights
      reserved.
FAU - Stacpoole, Peter W
AU  - Stacpoole PW
AD  - University of Florida, USA. pws@ufl.edu
FAU - deGrauw, Ton J
AU  - deGrauw TJ
FAU - Feigenbaum, Annette S
AU  - Feigenbaum AS
FAU - Hoppel, Charles
AU  - Hoppel C
FAU - Kerr, Douglas S
AU  - Kerr DS
FAU - McCandless, Shawn E
AU  - McCandless SE
FAU - Miles, Michael V
AU  - Miles MV
FAU - Robinson, Brian H
AU  - Robinson BH
FAU - Tang, Peter H
AU  - Tang PH
LA  - eng
GR  - R01 FD003032/FD/FDA HHS/United States
GR  - UL1 RR029890/RR/NCRR NIH HHS/United States
GR  - UL1 TR000064/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20120925
PL  - Netherlands
TA  - Mitochondrion
JT  - Mitochondrion
JID - 100968751
RN  - 1339-63-5 (Ubiquinone)
RN  - EJ27X76M46 (coenzyme Q10)
SB  - IM
EIN - Mitochondrion. 2013 Nov;13(6):953
MH  - Biomedical Research
MH  - Humans
MH  - Mitochondrial Diseases/*congenital/*drug therapy
MH  - Research Design
MH  - Ubiquinone/*analogs & derivatives/therapeutic use
PMC - PMC3975832
MID - NIHMS567183
EDAT- 2012/10/02 06:00
MHDA- 2013/04/18 06:00
CRDT- 2012/10/02 06:00
PHST- 2012/06/21 00:00 [received]
PHST- 2012/08/17 00:00 [revised]
PHST- 2012/09/18 00:00 [accepted]
PHST- 2012/10/02 06:00 [entrez]
PHST- 2012/10/02 06:00 [pubmed]
PHST- 2013/04/18 06:00 [medline]
AID - S1567-7249(12)00220-6 [pii]
AID - 10.1016/j.mito.2012.09.005 [doi]
PST - ppublish
SO  - Mitochondrion. 2012 Nov;12(6):623-9. doi: 10.1016/j.mito.2012.09.005. Epub 2012
      Sep 25.


PMID- 23022201
OWN - NLM
STAT- MEDLINE
DCOM- 20140203
LR  - 20130228
IS  - 1695-9531 (Electronic)
IS  - 1695-4033 (Linking)
VI  - 78
IP  - 3
DP  - 2013 Mar
TI  - [Recommendations on making decisions and end of life care in neonatology].
PG  - 190.e1-190.e14
LID - 10.1016/j.anpedi.2012.07.012 [doi]
LID - S1695-4033(12)00339-6 [pii]
AB  - Healthcare-professionals who work in neonatal units believe that a very important
      part of their work is the care of sick newborns, and their families if the
      neonate has an incurable disease or will die. The effort is focused on preventing
      disproportionate and unnecessary treatments that result in pain and discomfort,
      and also separate the child from his family. These situations usually occur when 
      the infant has a terminal illness, extreme immaturity with complications, or
      severe birth defects. In this paper, the Ethics Working Group of the Spanish
      Society of Neonatology reflects on decision making at this time of life. The
      ethical aspects are reviewed, including, limiting treatment, the basis of
      decision-making process (that should include adequate information), the
      relationship of trust, and deliberation between parents and professionals to make
      the right decision. It highlights the importance of caring for the family in a
      complex situation and of great suffering, when faced with the recommendation of
      professionals to limit treatment because their child suffers from a disease with 
      a poor prognosis. The care of the sick neonate care at the end of life, and their
      families requires a considerable effort, dedication and training of all health
      personnel. The repeated experience of being close to suffering and death can
      adversely affect the professionals involved. Finally, there is mention of the
      legal aspects of limiting treatment, how to perform and document decision
      process, the withdrawal of life support, assessment of symptoms and pain control 
      and sedation.
CI  - Copyright (c) 2012 Asociacion Espanola de Pediatria. Published by Elsevier
      Espana. All rights reserved.
FAU - Tejedor Torres, J C
AU  - Tejedor Torres JC
AD  - Unidad Neonatal, Hospital de Mostoles, Madrid, Espana.
FAU - Lopez de Heredia Goya, J
AU  - Lopez de Heredia Goya J
FAU - Herranz Rubia, N
AU  - Herranz Rubia N
FAU - Nicolas Jimenez, P
AU  - Nicolas Jimenez P
FAU - Garcia Munoz, F
AU  - Garcia Munoz F
FAU - Perez Rodriguez, J
AU  - Perez Rodriguez J
CN  - Grupo de Trabajo de Etica de la Sociedad Espanola de Neonatologia
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Practice Guideline
TT  - Recomendaciones sobre toma de decisiones y cuidados al final de la vida en
      neonatologia.
DEP - 20120928
PL  - Spain
TA  - An Pediatr (Barc)
JT  - Anales de pediatria (Barcelona, Spain : 2003)
JID - 101162596
SB  - IM
MH  - Algorithms
MH  - Decision Making
MH  - Family
MH  - Grief
MH  - Humans
MH  - Infant, Newborn
MH  - Neonatology/legislation & jurisprudence/*standards
MH  - Terminal Care/legislation & jurisprudence/*standards
IR  - Lopez de Heredia Goya J
FIR - Lopez de Heredia Goya, J
IR  - Perez Rodriguez J
FIR - Perez Rodriguez, J
IR  - Garcia Munoz F
FIR - Garcia Munoz, F
IR  - Blanco Bravo D
FIR - Blanco Bravo, D
IR  - Molina Morales V
FIR - Molina Morales, V
IR  - Tejedor Torres JC
FIR - Tejedor Torres, J C
IR  - Aguayo Maldonado J
FIR - Aguayo Maldonado, J
EDAT- 2012/10/02 06:00
MHDA- 2014/02/04 06:00
CRDT- 2012/10/02 06:00
PHST- 2012/05/26 00:00 [received]
PHST- 2012/07/16 00:00 [revised]
PHST- 2012/07/17 00:00 [accepted]
PHST- 2012/10/02 06:00 [entrez]
PHST- 2012/10/02 06:00 [pubmed]
PHST- 2014/02/04 06:00 [medline]
AID - S1695-4033(12)00339-6 [pii]
AID - 10.1016/j.anpedi.2012.07.012 [doi]
PST - ppublish
SO  - An Pediatr (Barc). 2013 Mar;78(3):190.e1-190.e14. doi:
      10.1016/j.anpedi.2012.07.012. Epub 2012 Sep 28.


PMID- 23021692
OWN - NLM
STAT- MEDLINE
DCOM- 20121213
LR  - 20220408
IS  - 1097-6868 (Electronic)
IS  - 0002-9378 (Linking)
VI  - 207
IP  - 4
DP  - 2012 Oct
TI  - A multicenter, randomized, prospective, controlled study comparing sacrospinous
      fixation and transvaginal mesh in the treatment of posthysterectomy vaginal vault
      prolapse.
PG  - 301.e1-7
LID - 10.1016/j.ajog.2012.08.016 [doi]
LID - S0002-9378(12)00864-2 [pii]
AB  - OBJECTIVE: The objective of the study was to compare recurrence and complication 
      rates for sacrospinous fixation (SSF) and prolene mesh techniques for the primary
      treatment of posthysterectomy vaginal vault prolapse. STUDY DESIGN: Patients
      undergoing surgery for vault prolapse were included in a multicenter, randomized,
      controlled study comparing SSF or total mesh (Prolift; Gynecare/Ethicon,
      Somerville, NJ). The examination included pelvic organ prolapse quantification,
      urodynamics, ultrasound, and quality-of-life (QoL) questionnaires before and 3
      and 12 months after surgery. RESULTS: Of 168 randomized patients, 83 underwent
      SSF and 85 mesh repair. Prolapse recurrence after 12 months occurred in 39.4% of 
      the SSF group and in 16.9% of the mesh group (P = .003). The mesh exposure rate
      was 20.8%. No difference in QoL improvement as well as of de novo stress urinary 
      incontinence and overactive bladder onset was found. CONCLUSION: Mesh exposure
      occurrence was balanced against a lower prolapse recurrence rate in the patients 
      undergoing mesh surgery compared with those undergoing SSF.
CI  - Copyright (c) 2012 Mosby, Inc. All rights reserved.
FAU - Halaska, Michael
AU  - Halaska M
AD  - Department of Obstetrics and Gynecology, First Medical Faculty of Charles
      University in Prague, Prague, Czech Republic. michael.halaska@lf1.cuni.cz
FAU - Maxova, Katerina
AU  - Maxova K
FAU - Sottner, Oldrich
AU  - Sottner O
FAU - Svabik, Kamil
AU  - Svabik K
FAU - Mlcoch, Michal
AU  - Mlcoch M
FAU - Kolarik, Dusan
AU  - Kolarik D
FAU - Mala, Ivana
AU  - Mala I
FAU - Krofta, Ladislav
AU  - Krofta L
FAU - Halaska, Michael J
AU  - Halaska MJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20120816
PL  - United States
TA  - Am J Obstet Gynecol
JT  - American journal of obstetrics and gynecology
JID - 0370476
SB  - IM
MH  - Aged
MH  - Female
MH  - Humans
MH  - Hysterectomy/*adverse effects
MH  - Ligaments/*surgery
MH  - Middle Aged
MH  - Pelvic Organ Prolapse/etiology/*surgery
MH  - Quality of Life
MH  - Recurrence
MH  - *Surgical Mesh
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
MH  - Urinary Incontinence, Stress/surgery
MH  - Vagina/*surgery
EDAT- 2012/10/02 06:00
MHDA- 2012/12/14 06:00
CRDT- 2012/10/02 06:00
PHST- 2012/03/03 00:00 [received]
PHST- 2012/07/16 00:00 [revised]
PHST- 2012/08/08 00:00 [accepted]
PHST- 2012/10/02 06:00 [entrez]
PHST- 2012/10/02 06:00 [pubmed]
PHST- 2012/12/14 06:00 [medline]
AID - S0002-9378(12)00864-2 [pii]
AID - 10.1016/j.ajog.2012.08.016 [doi]
PST - ppublish
SO  - Am J Obstet Gynecol. 2012 Oct;207(4):301.e1-7. doi: 10.1016/j.ajog.2012.08.016.
      Epub 2012 Aug 16.


PMID- 23020911
OWN - NLM
STAT- MEDLINE
DCOM- 20121210
LR  - 20121001
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 98
IP  - 4
DP  - 2012 Oct
TI  - Reproductive medicine and Turner syndrome: ethical issues.
PG  - 792-6
LID - 10.1016/j.fertnstert.2012.08.036 [doi]
LID - S0015-0282(12)02124-3 [pii]
AB  - This article discusses the ethical issues raised by the medical responses to
      Turner syndrome (TS). It explores the issues and challenges faced by women with
      Turner, and by prospective parents of a child with Turner. It focuses on four
      issues: the use of GH to increase height; the use of third-party oocytes to
      enable women with Turner to become pregnant; the parental decision to remove and 
      cryopreserve ovarian tissue from a child with Turner; and the termination of
      fetuses diagnosed with Turner. Many of the challenges associated with TS are
      directly or indirectly related to social attitudes and practices, from harsh
      teasing in school to health professionals' assumption that a woman will abort a
      fetus diagnosed with Turner. All the interventions designed to alleviate the
      difficulties faced by women with TS should be employed with caution, in part
      because they raise significant concerns about risk and consent; in part because
      they offer a medical response to problems that are to some extent social.
CI  - Copyright (c) 2012 American Society for Reproductive Medicine. Published by
      Elsevier Inc. All rights reserved.
FAU - Wasserman, David
AU  - Wasserman D
AD  - Center for Ethics at Yeshiva University, New York, New York 10033, USA.
      dwasserm@yu.edu
FAU - Asch, Adrienne
AU  - Asch A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
SB  - IM
MH  - Abortion, Induced/*ethics
MH  - Female
MH  - Humans
MH  - Infertility, Female/*therapy
MH  - Pregnancy
MH  - Pregnancy Complications/*therapy
MH  - Reproductive Medicine/*ethics
MH  - Turner Syndrome/*therapy
EDAT- 2012/10/02 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/10/02 06:00
PHST- 2012/06/15 00:00 [received]
PHST- 2012/08/17 00:00 [revised]
PHST- 2012/08/20 00:00 [accepted]
PHST- 2012/10/02 06:00 [entrez]
PHST- 2012/10/02 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - S0015-0282(12)02124-3 [pii]
AID - 10.1016/j.fertnstert.2012.08.036 [doi]
PST - ppublish
SO  - Fertil Steril. 2012 Oct;98(4):792-6. doi: 10.1016/j.fertnstert.2012.08.036.


PMID- 23020814
OWN - NLM
STAT- MEDLINE
DCOM- 20130326
LR  - 20211021
IS  - 1471-5945 (Electronic)
IS  - 1471-5945 (Linking)
VI  - 12
DP  - 2012 Sep 28
TI  - Experiences with surgical treatment of chronic lower limb ulcers at a tertiary
      hospital in northwestern Tanzania: a prospective review of 300 cases.
PG  - 17
LID - 10.1186/1471-5945-12-17 [doi]
AB  - BACKGROUND: Chronic lower limb ulcers constitute a major public health problem of
      great important all over the world and contribute significantly to high morbidity
      and long-term disabilities. There is paucity of information regarding chronic
      lower limb ulcers in our setting; therefore it was necessary to conduct this
      study to establish the patterns and outcome of chronic lower limb ulcers and to
      identify predictors of outcome in our local setting. METHODS: This was a
      descriptive prospective study of patients with chronic lower limb ulcers
      conducted at Bugando Medical Centre between November 2010 and April 2012. Ethical
      approval to conduct the study was sought from relevant authorities. Statistical
      data analysis was done using SPSS version 17.0 and STATA version 11.0. RESULTS: A
      total of 300 patients were studied. Their ages ranged from 3 months to 85 years
      (median 32 years). The male to female ratio was 2:1. The median duration of
      illness was 44 days. Traumatic ulcer was the most frequent type of ulcer
      accounting for 60.3% of patients. The median duration of illness was 44 days. The
      leg was commonly affected in 33.7% of cases and the right side (48.7%) was
      frequently involved. Out of 300 patients, 212 (70.7%) had positive aerobic
      bacterial growth within 48 hours of incubation. Pseudomonas aeruginosa (25.5%)
      was the most frequent gram negative bacteria isolated, whereas gram positive
      bacteria commonly isolated was Staphylococcus aureus (13.7%). Twenty (6.7%)
      patients were HIV positive with a median CD4+ count of 350 cells/mul. Mycological
      investigation was not performed. Bony involvement was radiologically reported in 
      83.0% of cases. Histopathological examination performed in 56 patients revealed
      malignancy in 20 (35.7%) patients, of which malignant melanoma (45.0%) was the
      most common histopathological type. The vast majority of patients, 270 (90.0%)
      were treated surgically, and surgical debridement was the most common surgical
      procedure performed in 24.1% of cases. Limb amputation rate was 8.7%.
      Postoperative complication rate was 58.3% of which surgical site infection
      (77.5%) was the most common post-operative complications. The median length of
      hospital stay was 23 days. Mortality rate was 4.3%. Out of the two hundred and
      eighty-seven (95.7%) survivors, 253 (91.6%) were treated successfully and
      discharged well (healed). After discharge, only 35.5% of cases were available for
      follow up at the end of study period. CONCLUSION: Chronic lower limb ulcers
      remain a major public health problem in this part of Tanzania. The majority of
      patients in our environment present late when the disease is already in advanced 
      stages. Early recognition and aggressive treatment of the acute phase of chronic 
      lower limb ulcers at the peripheral hospitals and close follow-up are urgently
      needed to improve outcomes of these patients in our environment.
FAU - Mbunda, Fidelis
AU  - Mbunda F
AD  - Department of Surgery, Catholic University of Health and Allied Sciences-
      Bugando, Mwanza, Tanzania.
FAU - McHembe, Mabula D
AU  - McHembe MD
FAU - Chalya, Phillipo L
AU  - Chalya PL
FAU - Rambau, Peter
AU  - Rambau P
FAU - Mshana, Stephen E
AU  - Mshana SE
FAU - Kidenya, Benson R
AU  - Kidenya BR
FAU - Gilyoma, Japhet M
AU  - Gilyoma JM
LA  - eng
PT  - Journal Article
DEP - 20120928
PL  - England
TA  - BMC Dermatol
JT  - BMC dermatology
JID - 100968541
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Amputation
MH  - Bacteria/isolation & purification
MH  - Child
MH  - Child, Preschool
MH  - Debridement/*methods
MH  - Female
MH  - HIV Seropositivity/complications
MH  - Humans
MH  - Infant
MH  - Leg Ulcer/microbiology/*surgery
MH  - Lower Extremity/*surgery
MH  - Male
MH  - Middle Aged
MH  - Postoperative Complications
MH  - Prospective Studies
MH  - Tanzania
MH  - Tertiary Care Centers
MH  - Young Adult
PMC - PMC3507740
EDAT- 2012/10/02 06:00
MHDA- 2013/03/27 06:00
CRDT- 2012/10/02 06:00
PHST- 2012/05/28 00:00 [received]
PHST- 2012/09/23 00:00 [accepted]
PHST- 2012/10/02 06:00 [entrez]
PHST- 2012/10/02 06:00 [pubmed]
PHST- 2013/03/27 06:00 [medline]
AID - 1471-5945-12-17 [pii]
AID - 10.1186/1471-5945-12-17 [doi]
PST - epublish
SO  - BMC Dermatol. 2012 Sep 28;12:17. doi: 10.1186/1471-5945-12-17.


PMID- 23020047
OWN - NLM
STAT- MEDLINE
DCOM- 20130304
LR  - 20151119
IS  - 1898-2263 (Electronic)
IS  - 1232-1966 (Linking)
VI  - 19
IP  - 3
DP  - 2012
TI  - Physicians' religiosity and attitudes towards patients.
PG  - 503-7
AB  - BACKGROUND: Many religions underline the value of merciful acts, especially the
      care of the sick. The aim of the survey was to verify the hypothesis that a
      higher religiosity correlates with a more desirable ethical attitude towards
      patients. METHOD: An anonymous questionnaire consisting of standardized tools:
      Scale of Attitudes towards the Patient (SAtP) (four dimensions: respect for
      autonomy, altruism, empathy and holistic approach to a patient), the Scale of
      Religious Attitudes (SReAt) evaluating the religiosity, and some questions
      related to the role of religious beliefs in respondents' professional lives. The 
      research was carried out on a group of 528 Polish physicians, 324 of whom
      returned the questionnaire (return = 61%); 51% women, 49% men; average work
      experience: 17.03 years; 93% Catholics. RESULTS: Religiosity correlates
      positively with altruism (r=0.12; p<0.05), holistic approach (r=0.18; p<0.01) and
      empathy (r=0.20; p<0.01), but not with respect for autonomy. For the majority of 
      physicians, religious faith is an important supportive factor, especially in
      making difficult decisions. Surgeons are less religious (M=5.32; SD=1.06) than
      non-surgeons (M=5.61; SD=0.93); (t= -2.59, p<0.05). CONCLUSION: Physicians'
      religiosity is an essential factor shaping their attitude towards patients. The
      majority of physicians declared that their religious faith influences their
      professional decisions, especially in difficult situations. The religiosity
      variable explains physicians' moral attitude better than the denomination
      (religious affiliation) variable. Physician-patient relation frameworks should
      take into account not only patients' but also physicians' cultural and religious 
      beliefs.
FAU - Pawlikowski, Jakub
AU  - Pawlikowski J
AD  - Department of Ethics and Human Philosophy, Medical University of Lublin, Poland. 
      jpawlikowski@wp.pl
FAU - Sak, Jaroslaw Jerzy
AU  - Sak JJ
FAU - Marczewski, Krzysztof
AU  - Marczewski K
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - Ann Agric Environ Med
JT  - Annals of agricultural and environmental medicine : AAEM
JID - 9500166
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Female
MH  - Humans
MH  - Male
MH  - *Physician-Patient Relations
MH  - Physicians
MH  - Poland
MH  - *Religion and Medicine
MH  - Surveys and Questionnaires
EDAT- 2012/10/02 06:00
MHDA- 2013/03/05 06:00
CRDT- 2012/10/02 06:00
PHST- 2012/10/02 06:00 [entrez]
PHST- 2012/10/02 06:00 [pubmed]
PHST- 2013/03/05 06:00 [medline]
AID - 1010941 [pii]
PST - ppublish
SO  - Ann Agric Environ Med. 2012;19(3):503-7.


PMID- 25991976
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151026
LR  - 20200930
IS  - 1809-9777 (Print)
IS  - 1809-4864 (Linking)
VI  - 16
IP  - 4
DP  - 2012 Oct
TI  - Cochlear implants: our experience and literature review.
PG  - 476-81
LID - 10.7162/S1809-97772012000400008 [doi]
AB  - INTRODUCTION: Cochlear Implants are important for individuals with severe to
      profound bilateral sensorineural hearing loss. OBJECTIVE: Evaluate the experience
      of cochlear implant center of Otorhinolaryngology through the analysis of records
      of 9 patients who underwent cochlear implant surgery. METHODS: This is a
      retrospective study performed with the patients records. Number 0191.0.107.000-11
      ethics committee approval. We evaluated gender, etiology, age at surgery,
      duration of deafness, classification of deafness, unilateral or bilateral
      surgery, intraoperative and postoperative neural response and impedance of the
      electrodes in intraoperative and preoperative tests and found those that
      counter-indicated surgery. RESULTS: There were 6 pediatric and 3 adult patients. 
      Four male and 5 female. Etiologies: maternal rubella, cytomegalovirus,
      ototoxicity, meningitis, and sudden deafness. The age at surgery and duration of 
      deafness ranged from 2-46 years and 2-18 years, respectively. Seven patients were
      pre-lingual. All had profound bilateral PA. There were 7 bilateral implants.
      Intraoperative complications: hemorrhage. Complications after surgery: vertigo
      and internal device failure. In 7 patients the electrodes were implanted through.
      Telemetry showed satisfactory neural response and impedance. CT and MRI was
      performed in all patients. We found enlargement of the vestibular aqueduct in a
      patient and incudomalleolar malformation. CONCLUSION: The cochlear implant as a
      form of auditory rehabilitation is well established and spreading to different
      centers specialized in otoaudiology. Thus, the need for structured services and
      trained professionals in this type of procedure is clear.
FAU - Martins, Mariane Barreto Brandao
AU  - Martins MB
AD  - Doctor. Specializing in Otolaryngology.
FAU - de Lima, Francis Vinicius Fontes
AU  - de Lima FV
AD  - Doctor. Specializing in Otolaryngology.
FAU - Santos, Ronaldo Carvalho Junior
AU  - Santos RC Junior
AD  - Doctor of Medicine (Otolaryngology), University of Sao Paulo. Head of the
      Department of Otorhinolaryngology, University Hospital, Faculty of Medicine,
      Federal University of Sergipe.
FAU - Santos, Arlete Cristina Granizo
AU  - Santos AC
AD  - Otorhinolaryngologist. Teacher of the Residents of Otorhinolaryngology of the
      University Hospital of the Faculty of Medicine of the Federal University of
      Sergipe.
FAU - Barreto, Valeria Maria Prado
AU  - Barreto VM
AD  - Master of Health Sciences, Federal University of Sergipe. Teacher of the
      Residents of Otorhinolaryngology of the University Hospital of the Faculty of
      Medicine of the Federal University of Sergipe.
FAU - de Jesus, Eduardo Passos Fiel
AU  - de Jesus EP
AD  - Otorhinolaryngologist. Teacher of the Residents of Otorhinolaryngology of the
      University Hospital of the Faculty of Medicine of the Federal University of
      Sergipe.
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - Int Arch Otorhinolaryngol
JT  - International archives of otorhinolaryngology
JID - 101637652
PMC - PMC4432535
OTO - NOTNLM
OT  - cochlear implants
OT  - hearing loss
OT  - sensorineural
EDAT- 2012/10/01 00:00
MHDA- 2012/10/01 00:01
CRDT- 2015/05/21 06:00
PHST- 2012/04/19 00:00 [received]
PHST- 2012/07/31 00:00 [accepted]
PHST- 2015/05/21 06:00 [entrez]
PHST- 2012/10/01 00:00 [pubmed]
PHST- 2012/10/01 00:01 [medline]
AID - 10.7162/S1809-97772012000400008 [doi]
AID - 160408 [pii]
PST - ppublish
SO  - Int Arch Otorhinolaryngol. 2012 Oct;16(4):476-81. doi:
      10.7162/S1809-97772012000400008.


PMID- 25945206
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150506
LR  - 20201001
IS  - 1945-2020 (Print)
IS  - 1945-2020 (Linking)
VI  - 4
IP  - 2
DP  - 2012 Fall
TI  - Tele-AAC Resolution.
PG  - 79-82
LID - 10.5195/IJT.2012.6106 [doi]
AB  - Approximately 1.3% of all people, or about 4 million Americans, cannot rely on
      their natural speech to meet their daily communication needs. Telepractice offers
      a potentially cost-effective service delivery mechanism to provide clinical AAC
      services at a distance to the benefit of underserved populations in the United
      States and worldwide. Tele-AAC is a unique cross-disciplinary clinical service
      delivery model that requires expertise in both telepractice and augmentative and 
      alternative communication (AAC) systems. The Tele-AAC Working Group of the 2012
      ISAAC Research Symposium therefore drafted a resolution underscoring the
      importance of identifying and characterizing the unique opportunities and
      constraints of Tele-AAC in all aspects of service delivery. These include, but
      are not limited to: needs assessments; implementation planning; device/system
      procurement, set-up and training; quality assurance, client progress monitoring, 
      and follow-up service delivery. Tele-AAC, like other telepractice applications,
      requires adherence to the ASHA Code of Ethics and other policy documents, and
      state, federal, and international laws, as well as a competent technological
      infrastructure. The Working Group recommends that institutions of higher
      education and professional organizations provide training in Tele-AAC service
      provision. In addition, research and development are needed to create validity
      measures across Tele-AAC practices (i.e., assessment, implementation, and
      consultation); determine the communication competence levels achieved by Tele-AAC
      users; discern stakeholders' perceptions of Tele-AAC services (e.g.,
      acceptability and viability); maximize Tele-AAC's capacity to engage multiple
      team members in AAC assessment and ongoing service; identify the limitations and 
      barriers of Tele-AAC provision; and develop potential solutions.
FAU - Anderson, Kate
AU  - Anderson K
AD  - University of Sydney, Australia.
FAU - Boisvert, Michelle K
AU  - Boisvert MK
AD  - University of Massachusetts, Amherst, MA.
FAU - Doneski-Nicol, Janis
AU  - Doneski-Nicol J
AD  - University of Massachusetts, Amherst, MA.
FAU - Gutmann, Michelle L
AU  - Gutmann ML
AD  - Department of Hearing and Speech Sciences, Vanderbilt University, Nashville, TN.
FAU - Hall, Nerissa C
AU  - Hall NC
AD  - University of Massachusetts, Amherst, MA.
FAU - Morelock, Cynthia
AU  - Morelock C
AD  - The Children's Institute of Pittsburgh, Pittsburgh, PA.
FAU - Steele, Richard
AU  - Steele R
AD  - Lingraphica, Princeton, NJ.
FAU - Cohn, Ellen R
AU  - Cohn ER
AD  - School of Health and Rehabilitation Sciences, University of Pittsburgh,
      Pittsburgh, PA.
LA  - eng
PT  - Journal Article
DEP - 20121209
PL  - United States
TA  - Int J Telerehabil
JT  - International journal of telerehabilitation
JID - 101604321
PMC - PMC4296823
OTO - NOTNLM
OT  - Augmentative and Alternative Communication (AAC)
OT  - Tele-AAC
OT  - telepractice
EDAT- 2012/10/01 00:00
MHDA- 2012/10/01 00:01
CRDT- 2015/05/07 06:00
PHST- 2015/05/07 06:00 [entrez]
PHST- 2012/10/01 00:00 [pubmed]
PHST- 2012/10/01 00:01 [medline]
AID - 10.5195/IJT.2012.6106 [doi]
AID - v4n2-art-10.5195-ijt.2012.6106 [pii]
PST - epublish
SO  - Int J Telerehabil. 2012 Dec 9;4(2):79-82. doi: 10.5195/IJT.2012.6106. eCollection
      2012 Fall.


PMID- 25453004
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141202
LR  - 20200930
IS  - 2276-6944 (Print)
IS  - 2276-6944 (Linking)
VI  - 2
IP  - 4
DP  - 2012 Oct
TI  - Comparison of intubating conditions with propofol suxamethonium versus
      propofol-LIDOCAINE.
PG  - 51-67
AB  - BACKGROUND: Suxamethonium is a depolarising muscle relaxant that provides rapid, 
      excellent intubating condition and ease of intubation. Its adverse effects has
      led to the search for comparable alternatives. Propofol alone provides fair
      intubating conditions and ease of tracheal intubation. Addition of intravenous
      lidocaine to propofol has been reported to enhance intubating conditions. AIM:
      The study compared the intubating conditions and ease of tracheal intubation
      following intravenous administration of propofol and suxamethonium (PS) with
      propofol and lidocaine (PL). SETTING OF THE STUDY: The study was carried out in
      the department of Anaesthesia of the University of Benin Teaching Hospital, Benin
      City, Edo state, Nigeria. DESIGN OF THE STUDY: This is a prospective randomized
      double-blinded controlled study. Ethical approval was obtained from the
      University of Benin Ethics and Research committee. MATERIALS AND METHODS:
      Eighty-eight eligible patients, aged 18-45 years, were prospectively randomized
      to 2 groups, PS and PL. Group PS received 2mg/kg propofol and 1.5mg/kg
      suxamethonium. Group PL had 2mg/kg propofol and 1.5mg/kg intravenous lidocaine.
      Intubating condition was determined, using a scale of 0 - 6 derived from jaw
      relaxation, ease of intubation and reflex response to intubation. Intubating
      condition was scored as good = 5-6, moderate = 3-4 and poor = 0-2. RESULTS: The
      propofol-suxamethonium (PS) group had 100% good intubating condition and
      successful intubation. The propofol-lidocaine (PL) group had 59.1% moderate and
      11.3% poor intubating conditions, with 70.5% successful and 29.5% failed
      intubation rates respectively. CONCLUSION: Laryngoscopy and endotracheal
      intubation are possible with appropriate doses of propofol and lidocaine, without
      the use of suxamethonium.
FAU - Isesele, To
AU  - Isesele T
FAU - Amadasun, Fe
AU  - Amadasun F
FAU - Edomwonyi, Np
AU  - Edomwonyi N
LA  - eng
PT  - Journal Article
PL  - India
TA  - J West Afr Coll Surg
JT  - Journal of the West African College of Surgeons
JID - 101597958
PMC - PMC4220484
OTO - NOTNLM
OT  - Endotracheal intubation
OT  - Lidocaine
OT  - Opioids
OT  - Propofol
OT  - Suxamethonium
EDAT- 2012/10/01 00:00
MHDA- 2012/10/01 00:01
CRDT- 2014/12/03 06:00
PHST- 2014/12/03 06:00 [entrez]
PHST- 2012/10/01 00:00 [pubmed]
PHST- 2012/10/01 00:01 [medline]
PST - ppublish
SO  - J West Afr Coll Surg. 2012 Oct;2(4):51-67.


PMID- 24892434
OWN - NLM
STAT- MEDLINE
DCOM- 20150930
LR  - 20181202
IS  - 0124-0064 (Print)
IS  - 0124-0064 (Linking)
VI  - 14
IP  - 6
DP  - 2012 Oct
TI  - Current professional practice in Brazilian mental healthcare services.
PG  - 937-47
LID - S0124-00642012001000004 [pii]
AB  - OBJECTIVE: Mental health reform in Brazil presupposes mental health becoming
      integrated into the Brazilian health system, involving multidisciplinary teams
      whose professional practice has yet to be defined. The present study forms part
      of a project aimed at understanding human resources practices in Brazilian mental
      healthcare services. METHODS: This was a descriptive, exploratory study using a
      sample of highly qualified practitioners involved in the Ribeirao Preto/SP public
      mental health network. The project was approved by the Ribeirao Preto College of 
      Nursing/University of Sao Paulo's ethics committee. A semi-structured
      questionnaire was used and the data was statistically analyzed. RESULTS: One
      hundred and forty-four of the 193 practitioners from the 8 public mental and
      psychiatric health care services agreed to participate. It was observed that
      current practice was mainly based on individual care, emphasizing medical,
      psychological and nursing care. Group activities were more frequently provided by
      community services. CONCLUSION: Mental care was infrequently prescribed and a low
      value was placed on activities like observation, recording and therapeutic
      interaction. Mental care services were being structured; however, practitioners
      still had difficulties in implementing current policy.
FAU - Ferreira-Furegato, Antonia R
AU  - Ferreira-Furegato AR
AD  - College of Nursing, University of Sao Paulo, Sao Paulo, Brazil,
      furegato@eerp.usp.br.
FAU - Frari-Galera, Sueli A
AU  - Frari-Galera SA
AD  - College of Nursing, University of Sao Paulo, Sao Paulo, Brazil,
      furegato@eerp.usp.br.
FAU - Pillon, Sandra C
AU  - Pillon SC
AD  - College of Nursing, University of Sao Paulo, Sao Paulo, Brazil,
      furegato@eerp.usp.br.
FAU - Cardoso, Lucilene
AU  - Cardoso L
AD  - College of Nursing, University of Sao Paulo, Sao Paulo, Brazil,
      furegato@eerp.usp.br.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Colombia
TA  - Rev Salud Publica (Bogota)
JT  - Revista de salud publica (Bogota, Colombia)
JID - 100936348
SB  - IM
MH  - Brazil
MH  - Humans
MH  - *Mental Health Services
MH  - *Professional Practice
MH  - *Psychiatry
MH  - Workforce
EDAT- 2012/10/01 00:00
MHDA- 2015/10/01 06:00
CRDT- 2014/06/04 06:00
PHST- 2011/05/23 00:00 [received]
PHST- 2012/02/27 00:00 [accepted]
PHST- 2014/06/04 06:00 [entrez]
PHST- 2012/10/01 00:00 [pubmed]
PHST- 2015/10/01 06:00 [medline]
AID - S0124-00642012001000004 [pii]
PST - ppublish
SO  - Rev Salud Publica (Bogota). 2012 Oct;14(6):937-47.


PMID- 24845044
OWN - NLM
STAT- MEDLINE
DCOM- 20150105
LR  - 20160511
IS  - 1947-5543 (Electronic)
IS  - 1947-5543 (Linking)
VI  - 10
IP  - 5
DP  - 2012 Oct
TI  - Biobanking, consent, and control: a survey of Albertans on key research ethics
      issues.
PG  - 433-8
LID - 10.1089/bio.2012.0029 [doi]
AB  - While the development of large scale biobanks continues, ethics and policy
      challenges persist. Debate surrounds key issues such as giving and withdrawing
      consent, incidental findings and return of results, and ownership and control of 
      tissue samples. Studies of public perception have demonstrated a lack of
      consensus on these issues, particularly in different jurisdictions. We conducted 
      a telephone survey of members of the public in Alberta, Canada. The survey
      addressed the aforementioned issues, but also explored public trust in the
      individuals and institutions involved in biobanking research. Results show that
      the Alberta public is fairly consistent in their responses and that those who
      preferred a broad consent model were also less likely to desire continuing
      control and a right to withdraw samples. The study raises questions about the
      role of public perceptions and opinions, particularly in the absence of
      consensus.
FAU - Caulfield, Timothy
AU  - Caulfield T
AD  - Health Law and Science Policy Group, Faculty of Law, University of Alberta ,
      Edmonton, Alberta, Canada .
FAU - Rachul, Christen
AU  - Rachul C
FAU - Nelson, Erin
AU  - Nelson E
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Biopreserv Biobank
JT  - Biopreservation and biobanking
JID - 101507284
SB  - IM
MH  - Adult
MH  - Biological Specimen Banks/*ethics
MH  - Biomedical Research
MH  - Canada
MH  - Data Collection
MH  - *Ethics, Research
MH  - Female
MH  - Humans
MH  - Male
MH  - Perception
MH  - Trust
EDAT- 2012/10/01 00:00
MHDA- 2015/01/06 06:00
CRDT- 2014/05/22 06:00
PHST- 2014/05/22 06:00 [entrez]
PHST- 2012/10/01 00:00 [pubmed]
PHST- 2015/01/06 06:00 [medline]
AID - 10.1089/bio.2012.0029 [doi]
PST - ppublish
SO  - Biopreserv Biobank. 2012 Oct;10(5):433-8. doi: 10.1089/bio.2012.0029.


PMID- 24716139
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140409
LR  - 20211021
IS  - 2225-4110 (Print)
IS  - 2225-4110 (Linking)
VI  - 2
IP  - 4
DP  - 2012 Oct
TI  - Dilong: food for thought and medicine.
PG  - 242-8
AB  - EARTHWORMS HAVE SEVERAL NAMES IN DIFFERENT COUNTRIES (IN CHINESE: di long,
      Japanese: Mimizu, Korean: Jireongi, Spanish: Lombriz de tierra, French: Ver de
      terre, German: Regenwurm, Italian: Lombrico, Swedish: Daggmask, Portuguese:
      Minhoca). They have long been used as a food source as well as treatments of
      various ailments. Many alternative and traditional disciplines of medicine, such 
      as those in China, Japan, and Korea, developed medicinal uses of dilong from an
      initial utilization as nutrition. Increased curiosity in the potential medicinal 
      properties of dilong has come to fruition through bioprospecting and evidence
      based research. This increased questioning and searching spawned first from a
      growing knowledge base about the earthworm's innate immune system. Their
      importance in understanding the evolution of the innate immune system has long
      been overlooked because of the ecological importance in soil preservation,
      earthworm immune systems, being full of leukocytes and humoral products, offer
      significant advantages when used as medicines. Earthworms offer an unanticipated 
      slew of potential health benefits without common drawbacks that come with other
      biological, alternative forms of medicine such as cost, ethical and pathological 
      concerns of animal testing.
FAU - Cooper, Edwin L
AU  - Cooper EL
AD  - Laboratory of Comparative Neuroimmunology, Department of Neurobiology; David
      Geffen School Of Medicine at UCLA, University of California, Los Angeles
      90095-1763 ; Honorary University Professor Taipei Medical University (TMU) ;
      Graduate Institute of Basic Medical Sciences (CMU) ; Distinguished Professor
      Founding Editor in Chief DCI (1977); eCAM (2004); Editor in Chief, JECM (2009).
FAU - Hirabayashi, Kyle
AU  - Hirabayashi K
AD  - Laboratory of Comparative Neuroimmunology, Department of Neurobiology; David
      Geffen School Of Medicine at UCLA, University of California, Los Angeles
      90095-1763.
FAU - Balamurugan, Mariappan
AU  - Balamurugan M
AD  - Division of Vermibiotechnology, Department of Zoology, Annamalai University,
      Annamalai Nagar-608002, India.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Tradit Complement Med
JT  - Journal of traditional and complementary medicine
JID - 101605474
PMC - PMC3942902
OTO - NOTNLM
OT  - Earthworms (Dilong)
OT  - Food
OT  - Natural Products
EDAT- 2012/10/01 00:00
MHDA- 2012/10/01 00:01
CRDT- 2014/04/10 06:00
PHST- 2014/04/10 06:00 [entrez]
PHST- 2012/10/01 00:00 [pubmed]
PHST- 2012/10/01 00:01 [medline]
AID - 10.1016/s2225-4110(16)30110-9 [doi]
PST - ppublish
SO  - J Tradit Complement Med. 2012 Oct;2(4):242-8. doi: 10.1016/s2225-4110(16)30110-9.


PMID- 24335741
OWN - NLM
STAT- MEDLINE
DCOM- 20140602
LR  - 20211021
IS  - 1548-7148 (Electronic)
IS  - 1088-4602 (Linking)
VI  - 23
IP  - 3
DP  - 2012 Oct
TI  - American Society for Pain Management nursing position statement: pain management 
      in patients with substance use disorders.
PG  - 210-22
LID - 10.1097/JAN.0b013e318271c123 [doi]
AB  - The American Society for Pain Management Nursing (ASPMN) has updated its position
      statement on managing pain in patients with substance use disorders. This
      position statement is endorsed by the International Nurses Society on Addictions 
      (IntNSA) and includes clinical practice recommendations based on current
      evidence. It is the position of ASPMN and IntNSA that every patient with pain,
      including those with substance use disorders, has the right to be treated with
      dignity, respect, and high-quality pain assessment and management. Failure to
      identify and treat the concurrent conditions of pain and substance use disorders 
      will compromise the ability to treat either condition effectively. Barriers to
      caring for these patients include stigmatization, misconceptions, and limited
      access to providers skilled in these two categories of disorders. Topics
      addressed in this position statement include the scope of substance use and
      related disorders, conceptual models of addiction, ethical considerations,
      addiction risk stratification, and clinical recommendations.
FAU - Oliver, June
AU  - Oliver J
AD  - From the *Swedish Covenant Hospital, Chicago, IL; daggerHospice Care of the Low
      Country and Coastal Pain and Spine Center, Bluffton, SC; double daggerUCLA School
      of Nursing, Los Angeles, CA; section signJames A. Haley Veterans Administration
      Medical Center & University of South Florida, Tampa, FL; parallelMatteliano Pain 
      Rehabilitation Center, Buffalo, NY; paragraph signHorizon Pharma, Deerfield,
      IL;**Fairview Ridges Hospital, Burnsville, MN; daggerdaggerUniversity of Michigan
      Addiction Treatment Services, Ann Arbor, MI; double daggerdouble
      daggerDoernbecher Children's Hospital/Oregon Health & Science University,
      Portland, OR. Correspondence related to content to: Barbara St. Marie, PhD, ANP, 
      GNP, RN-BC, Supervisor, Pain and Palliative Care, Fairview Ridges Hospital,
      Burnsville, MN 55337.
FAU - Coggins, Candace
AU  - Coggins C
FAU - Compton, Peggy
AU  - Compton P
FAU - Hagan, Susan
AU  - Hagan S
FAU - Matteliano, Deborah
AU  - Matteliano D
FAU - Stanton, Marsha
AU  - Stanton M
FAU - St Marie, Barbara
AU  - St Marie B
FAU - Strobbe, Stephen
AU  - Strobbe S
FAU - Turner, Helen N
AU  - Turner HN
CN  - American Society for Pain Management Nursing
LA  - eng
GR  - T32 NR011147/NR/NINR NIH HHS/United States
PT  - Journal Article
PT  - Practice Guideline
PL  - United States
TA  - J Addict Nurs
JT  - Journal of addictions nursing
JID - 9616159
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Prescription Drugs)
SB  - IM
MH  - Adolescent
MH  - Analgesics, Opioid/adverse effects/*therapeutic use
MH  - Behavior, Addictive/complications/epidemiology/psychology
MH  - Child
MH  - Ethics, Nursing
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Models, Theoretical
MH  - Pain/complications/*drug therapy/nursing
MH  - Pain Management/*ethics/nursing
MH  - Prescription Drugs/adverse effects/*therapeutic use
MH  - Self Medication/psychology/statistics & numerical data
MH  - Social Stigma
MH  - *Societies, Nursing
MH  - Substance-Related Disorders/complications/epidemiology/*nursing
MH  - Terminology as Topic
MH  - United States/epidemiology
PMC - PMC4033594
MID - NIHMS575341
EDAT- 2012/10/01 00:00
MHDA- 2014/06/03 06:00
CRDT- 2013/12/17 06:00
PHST- 2013/12/17 06:00 [entrez]
PHST- 2012/10/01 00:00 [pubmed]
PHST- 2014/06/03 06:00 [medline]
AID - 10.1097/JAN.0b013e318271c123 [doi]
AID - 00060867-201210000-00013 [pii]
PST - ppublish
SO  - J Addict Nurs. 2012 Oct;23(3):210-22. doi: 10.1097/JAN.0b013e318271c123.


PMID- 23019302
OWN - NLM
STAT- MEDLINE
DCOM- 20130429
LR  - 20220316
IS  - 1460-2350 (Electronic)
IS  - 0268-1161 (Linking)
VI  - 27
IP  - 12
DP  - 2012 Dec
TI  - BMI-related metabolic composition of the follicular fluid of women undergoing
      assisted reproductive treatment and the consequences for oocyte and embryo
      quality.
PG  - 3531-9
LID - 10.1093/humrep/des350 [doi]
AB  - STUDY QUESTION: Is the metabolic composition of the follicular fluid of women
      undergoing assisted reproductive treatment (ART) related to serum composition and
      BMI and is it associated with oocyte and embryo quality? SUMMARY ANSWER: We
      showed that metabolic alterations in the serum are reflected in the follicular
      fluid and that some of these alterations may affect oocyte quality, irrespective 
      of BMI. WHAT IS KNOWN ALREADY: Many studies have focused on the effect of
      metabolic disorders, such as obesity and type 2 diabetes, on assisted
      reproduction outcomes. There are, however, only few studies focusing on the
      importance of the correlation between serum and follicular fluid compositions and
      the composition of the follicular fluid as the oocyte's micro-environment,
      affecting its development and subsequent embryo quality. DESIGN, PARTICIPANTS AND
      SETTING: In this prospective cohort study, patient information, fertility
      treatment outcome data, follicular fluid and serum were obtained from women
      undergoing ART. Patients were categorized according to their BMI (kg/m(2)) as
      normal (n = 60), overweight (n = 26) or obese (n = 20). Serum and follicular
      fluid samples were analyzed for urea, total protein, albumin, cholesterol,
      high-density lipoprotein cholesterol, triglycerides, non-esterified fatty acids, 
      apolipoprotein A1, apolipoprotein B, glucose, lactate, C-reactive protein,
      insulin-like growth factor -1 (IGF-1), IGF-binding protein 3 (only in follicular 
      fluid), free carnitine and total carnitine. Metabolite concentrations in serum
      and follicular fluid samples were correlated and were associated with BMI and
      fertility treatment outcome. MAIN RESULTS: Most serum metabolite differences
      between patients were reflected in the follicular fluid (P < 0.05). Follicular
      fluid apolipoprotein A1 and follicular fluid total protein concentrations
      negatively affected oocyte quality parameters (P < 0.05). However, overall
      BMI-related associations were poor. BIAS, CONFOUNDING AND OTHER REASONS FOR
      CAUTION: In this study, we included every patient willing to participate. Within 
      this cohort, women with a BMI transcending 35 kg/m(2) were scarce (n = 2),
      because extremely overweight women are mostly advised to lose weight before
      starting ART. Furthermore, the number of patients in each BMI group was
      different, possibly masking associations between the metabolic composition of
      serum and follicular fluid and oocyte quality parameters. GENERALIZABILITY TO
      OTHER POPULATIONS: There were significant associations indicating that metabolic 
      changes in the serum are reflected in the follicular fluid, potentially affecting
      oocyte quality, irrespective of the patient's BMI. For ethical reasons, this
      study only focused on women already in need of artificial reproductive treatment.
      From a metabolic point of view, we consider this cohort as a representative
      sample of all women of reproductive age. STUDY FUNDING: This study was funded by 
      the special research fund, university of Antwerp (BOF UA). None of the authors
      has any conflict of interest to declare.
FAU - Valckx, S D M
AU  - Valckx SD
AD  - Veterinary Physiology and Biochemistry, Department of Veterinary Sciences,
      University of Antwerp, 2610 Wilrijk, Belgium. sara.valckx@ua.ac.be
FAU - De Pauw, I
AU  - De Pauw I
FAU - De Neubourg, D
AU  - De Neubourg D
FAU - Inion, I
AU  - Inion I
FAU - Berth, M
AU  - Berth M
FAU - Fransen, E
AU  - Fransen E
FAU - Bols, P E J
AU  - Bols PE
FAU - Leroy, J L M R
AU  - Leroy JL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120927
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
SB  - IM
MH  - Adult
MH  - Body Mass Index
MH  - Embryo, Mammalian
MH  - Embryonic Development/*physiology
MH  - Female
MH  - Follicular Fluid/*chemistry/metabolism
MH  - Humans
MH  - Infertility/blood/metabolism/therapy
MH  - Lipid Metabolism
MH  - Obesity/blood/*complications
MH  - Oocyte Retrieval
MH  - Oocytes/*physiology
MH  - Overweight/blood/*complications/metabolism
MH  - Prospective Studies
MH  - *Reproductive Techniques, Assisted
MH  - Treatment Outcome
EDAT- 2012/09/29 06:00
MHDA- 2013/04/30 06:00
CRDT- 2012/09/29 06:00
PHST- 2012/09/29 06:00 [entrez]
PHST- 2012/09/29 06:00 [pubmed]
PHST- 2013/04/30 06:00 [medline]
AID - des350 [pii]
AID - 10.1093/humrep/des350 [doi]
PST - ppublish
SO  - Hum Reprod. 2012 Dec;27(12):3531-9. doi: 10.1093/humrep/des350. Epub 2012 Sep 27.


PMID- 23019115
OWN - NLM
STAT- MEDLINE
DCOM- 20131209
LR  - 20141120
IS  - 1613-6829 (Electronic)
IS  - 1613-6810 (Linking)
VI  - 9
IP  - 9-10
DP  - 2013 May 27
TI  - Emerging in vitro models for safety screening of high-volume production
      nanomaterials under environmentally relevant exposure conditions.
PG  - 1504-20
LID - 10.1002/smll.201201452 [doi]
AB  - The rising production of nanomaterial-based consumer products has raised safety
      concerns. Testing these with animal and other direct models is neither ethically 
      nor economically viable, nor quick enough. This review aims to discuss the
      strength of in vitro testing, including the use of 2D and 3D cultures, stem
      cells, and tissue constructs, etc., which would give fast and repeatable answers 
      of a highly specific nature, while remaining relevant to in vivo outcomes. These 
      results can then be combined and the overall toxicity predicted with relative
      accuracy. Such in vitro models can screen potentially toxic nanomaterials which, 
      if required, can undergo further stringent studies in animals. The cyto- and
      phototoxicity of some high-volume production nanomaterials, using in vitro
      models, is also reviewed.
CI  - Copyright (c) 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Kathawala, Mustafa Hussain
AU  - Kathawala MH
AD  - Nanyang Technological University, School of Materials Science and Engineering, 50
      Nanyang Avenue, Singapore 639798, Singapore.
FAU - Xiong, Sijing
AU  - Xiong S
FAU - Richards, Mark
AU  - Richards M
FAU - Ng, Kee Woei
AU  - Ng KW
FAU - George, Saji
AU  - George S
FAU - Loo, Say Chye Joachim
AU  - Loo SC
LA  - eng
PT  - Journal Article
DEP - 20120928
PL  - Germany
TA  - Small
JT  - Small (Weinheim an der Bergstrasse, Germany)
JID - 101235338
SB  - IM
MH  - *Environmental Exposure
MH  - Humans
MH  - *Nanostructures
MH  - Stem Cells/drug effects
MH  - Tissue Engineering
MH  - Toxicity Tests
EDAT- 2012/09/29 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/09/29 06:00
PHST- 2012/06/26 00:00 [received]
PHST- 2012/09/29 06:00 [entrez]
PHST- 2012/09/29 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1002/smll.201201452 [doi]
PST - ppublish
SO  - Small. 2013 May 27;9(9-10):1504-20. doi: 10.1002/smll.201201452. Epub 2012 Sep
      28.


PMID- 23018533
OWN - NLM
STAT- MEDLINE
DCOM- 20130214
LR  - 20191112
IS  - 2233-6869 (Electronic)
IS  - 1598-9992 (Linking)
VI  - 60
IP  - 3
DP  - 2012 Sep 25
TI  - [Medical ethics as professional ethics].
PG  - 135-9
AB  - Contemporary medical ethics is far from the traditional concept of "In-Sul
      (benevolent art)" or "Yul-Li (, ethics), which emphasizes so much the personality
      or the character of a doctor. Nowadays, medical ethics should be considered as
      "professional ethics" which regulates the acts and medical practices of ordinary 
      doctors in their daily practice. The key concepts of the professional ethics are 
      "autonomy", "integrity", and "professional standard" established by medical
      organizations such as medical societies or associations. Most of Korean doctors
      have not been familiar with the concept of professional ethics or
      professionalism, which is due to the modern history of Korea. However, the
      concept of professional ethics is really critical to Korean doctors from the
      perspective of professional dignity and social respect to this profession. The
      current healthcare system of Korea is suffering from many problems of both
      private and public sector. Nonetheless, the professional ethics is urgently
      demanded for that very reason.
FAU - Kwon, Ivo
AU  - Kwon I
AD  - Department of Medical Education, Ewha Womans University School of Medicine, 1071 
      Anyangcheon-ro, Yangcheon-gu, Seoul 158-710, Korea. kivo@ewha.ac.kr
LA  - kor
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Korea (South)
TA  - Korean J Gastroenterol
JT  - The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
JID - 101189416
SB  - IM
MH  - Delivery of Health Care
MH  - *Ethics, Medical
MH  - *Ethics, Professional
MH  - Humans
MH  - Physician-Patient Relations
EDAT- 2012/09/29 06:00
MHDA- 2013/02/15 06:00
CRDT- 2012/09/29 06:00
PHST- 2012/09/29 06:00 [entrez]
PHST- 2012/09/29 06:00 [pubmed]
PHST- 2013/02/15 06:00 [medline]
AID - 201209201 [pii]
AID - 10.4166/kjg.2012.60.3.135 [doi]
PST - ppublish
SO  - Korean J Gastroenterol. 2012 Sep 25;60(3):135-9. doi: 10.4166/kjg.2012.60.3.135.


PMID- 23018401
OWN - NLM
STAT- MEDLINE
DCOM- 20121231
LR  - 20190911
IS  - 0080-6234 (Print)
IS  - 0080-6234 (Linking)
VI  - 46
IP  - 4
DP  - 2012 Aug
TI  - [The elderly with cognitive alterations in the context of poverty: a study of the
      social support network].
PG  - 906-13
LID - S0080-62342012000400018 [pii]
AB  - The objective of this study was to analyze the structure and role of social
      support networks for the elderly with cognitive alterations, who lived in a
      context of high or very high social vulnerability, and identify the associations 
      between the characteristics of the networks and functional capacity. The
      participants were 38 aged individuals living in a context of high or very high
      social vulnerability whose score on the Mini-Mental State Examination was below
      the cut-off point. All ethical considerations were observed. The following were
      administered: Mini-Mental State Examination, Convoy of Social Support, Katz
      Index, and Pfeffer Questionnaire. The results show that the elderly participants 
      have a large social network, with most members in their inner circle, but only a 
      few of the members play functional roles. A correlation was observed between the 
      gender variable and the number of social network members. No significant
      correlation was observed between network characteristics and the functional
      capacity of the elderly.
FAU - de Brito, Tabatta Renata Pereira
AU  - de Brito TR
AD  - Departamento de Gerontologia, Universidade Federal de Sao Carlos, Sao Carlos, SP,
      Brasil. tabatta_renata@hotmail.com
FAU - Costa, Reijane Salazar
AU  - Costa RS
FAU - Pavarini, Sofia Cristina Iost
AU  - Pavarini SC
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Idosos com alteracao cognitiva em contexto de pobreza: estudando a rede de apoio 
      social.
PL  - Brazil
TA  - Rev Esc Enferm USP
JT  - Revista da Escola de Enfermagem da U S P
JID - 0242726
MH  - Aged
MH  - Cognition Disorders/*psychology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Poverty/*psychology
MH  - *Social Support
EDAT- 2012/09/29 06:00
MHDA- 2013/01/01 06:00
CRDT- 2012/09/29 06:00
PHST- 2010/09/24 00:00 [received]
PHST- 2011/12/19 00:00 [accepted]
PHST- 2012/09/29 06:00 [entrez]
PHST- 2012/09/29 06:00 [pubmed]
PHST- 2013/01/01 06:00 [medline]
AID - S0080-62342012000400018 [pii]
AID - 10.1590/s0080-62342012000400018 [doi]
PST - ppublish
SO  - Rev Esc Enferm USP. 2012 Aug;46(4):906-13. doi: 10.1590/s0080-62342012000400018.


PMID- 23018400
OWN - NLM
STAT- MEDLINE
DCOM- 20121231
LR  - 20190911
IS  - 0080-6234 (Print)
IS  - 0080-6234 (Linking)
VI  - 46
IP  - 4
DP  - 2012 Aug
TI  - [The evaluation of the level of hope of elderly chronic kidney disease patients
      undergoing hemodialysis].
PG  - 900-5
LID - S0080-62342012000400017 [pii]
AB  - The objective of the present study was to evaluate the level of hope of elderly
      chronic kidney disease patients undergoing hemodialysis, using the Herth Hope
      Scale (HHS). This cross-sectional descriptive study was performed at a Renal
      Replacement Therapy Unit located in upstate Sao Paulo. The sample consisted of 50
      elderly patients currently undergoing hemodialysis treatment. After obtaining the
      participants' consent to participate, individual interviews were performed with
      the elderly individuals, utilizing a characterization instrument and the Herth
      Hope Scale. All of the ethical premises were complied with (protocol 512/2009).
      Regarding the results, most participants were male (60%) and their mean age was
      70.20 (+/-6.1) years. The mean score on the Herth Hope Scale was 36.20 (+/-2.90).
      In conclusion, compared with the Brazilian study regarding the validation of the 
      Herth Hope Scale, the subjects' level of hope was lower, thus indicating a need
      to intervene regarding this feeling.
FAU - Orlandi, Fabiana de Souza
AU  - Orlandi Fde S
AD  - Departamento de Enfermagem, Universidade Federal de Sao Carlos, Sao Carlos, SP,
      Brasil. forlandi@ufscar.br
FAU - Pepino, Barbara Garbelotti
AU  - Pepino BG
FAU - Pavarini, Sofia Cristina Iost
AU  - Pavarini SC
FAU - Dos Santos, Damiana Aparecida
AU  - Dos Santos DA
FAU - de Mendiondo, Marisa Silvana Zazzetta
AU  - de Mendiondo MS
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Avaliacao do nivel de esperanca de vida de idosos renais cronicos em hemodialise.
PL  - Brazil
TA  - Rev Esc Enferm USP
JT  - Revista da Escola de Enfermagem da U S P
JID - 0242726
MH  - Aged
MH  - Cross-Sectional Studies
MH  - *Emotions
MH  - Female
MH  - Humans
MH  - Male
MH  - Renal Dialysis/*psychology
MH  - Renal Insufficiency, Chronic/*psychology/*therapy
MH  - Surveys and Questionnaires
EDAT- 2012/09/29 06:00
MHDA- 2013/01/01 06:00
CRDT- 2012/09/29 06:00
PHST- 2010/08/27 00:00 [received]
PHST- 2011/12/19 00:00 [accepted]
PHST- 2012/09/29 06:00 [entrez]
PHST- 2012/09/29 06:00 [pubmed]
PHST- 2013/01/01 06:00 [medline]
AID - S0080-62342012000400017 [pii]
AID - 10.1590/s0080-62342012000400017 [doi]
PST - ppublish
SO  - Rev Esc Enferm USP. 2012 Aug;46(4):900-5. doi: 10.1590/s0080-62342012000400017.


PMID- 23018300
OWN - NLM
STAT- MEDLINE
DCOM- 20130619
LR  - 20220629
IS  - 1980-5322 (Electronic)
IS  - 1807-5932 (Linking)
VI  - 67
IP  - 9
DP  - 2012 Sep
TI  - Comparison of standard 4-row versus 6-row3-D linear cutter stapler in creation of
      gastrointestinal system anastomoses: a prospective randomized trial.
PG  - 1035-8
LID - S1807-59322012000900009 [pii]
AB  - OBJECTIVE: This prospective study was conducted to compare the clinical outcomes 
      of a 6-row 3-D linear cutter with the standard 4-row linear cutter in patients
      who underwent elective gastrointestinal surgery anastomosis. METHOD: Patients who
      underwent elective open gastrointestinal surgery that included stapled
      anastomosis using a linear cutter (Proximate(R), Ethicon Endo-Surgery,
      Cincinnati, OH) between January 2011 and May 2011 were included in the study. The
      patients were randomly assigned to two groups according to the linear cutter that
      was used in the surgery: the standard 4-row cutter (the S group) or the new 6-row
      cutter (the N group). The groups were compared based on the patient demographic
      data, the laboratory parameters, the preoperative diagnosis, the surgery
      performed, the operation time, intra-or postoperative complications, the time to 
      oral tolerance and the length of the hospital stay. RESULTS: The S group included
      11 male and nine female patients with a mean age of 65 +/- 12 (35-84) years,
      while the N group included 13 male and eight female patients with a mean age of
      62 +/- 11 (46-79) years (p =0.448, p = 0.443, respectively). Anastomotic line
      bleeding was observed in eight (40%) patients in the S group and in one (4.7%)
      patient in the N group (p = 0.006). Dehiscence of the anastomosis line was
      observed in two (10%) patients in the S group and none in the N group (p =0.131).
      Anastomotic leakage developed in three (15%) patients in the S group and in one
      (4.7%) patient in the N group (p = 0.269). The mean hospital stay was 12.65 +/-
      6.1 days in theS group and 9.52 +/- 2.9 days in the N group (p = 0.043).
      CONCLUSION: The 6-row 3-D linear cutter is a safe and easily applied instrument
      that can be used to create anastomoses in gastrointestinal surgery. The new
      stapler provides some usage benefits and is also superior to the standard linear 
      cutter with regard to anastomotic line bleeding.
FAU - Sozutek, Alper
AU  - Sozutek A
AD  - Department of Gastroenterological Surgery, Mersin University Medical Faculty,
      Mersin, Turkey. dralpers@hotmail.com
FAU - Colak, Tahsin
AU  - Colak T
FAU - Dag, Ahmet
AU  - Dag A
FAU - Olmez, Tolga
AU  - Olmez T
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Clinics (Sao Paulo)
JT  - Clinics (Sao Paulo, Brazil)
JID - 101244734
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anastomosis, Surgical/instrumentation
MH  - Blood Loss, Surgical
MH  - Chi-Square Distribution
MH  - Digestive System Surgical Procedures/*instrumentation/methods
MH  - Female
MH  - Humans
MH  - Length of Stay
MH  - Male
MH  - Middle Aged
MH  - Perioperative Period
MH  - Postoperative Hemorrhage
MH  - Prospective Studies
MH  - Reproducibility of Results
MH  - *Surgical Staplers
MH  - Time Factors
MH  - Treatment Outcome
PMC - PMC3438243
EDAT- 2012/09/29 06:00
MHDA- 2013/06/20 06:00
CRDT- 2012/09/29 06:00
PHST- 2012/04/24 00:00 [received]
PHST- 2012/05/10 00:00 [accepted]
PHST- 2012/09/29 06:00 [entrez]
PHST- 2012/09/29 06:00 [pubmed]
PHST- 2013/06/20 06:00 [medline]
AID - S1807-5932(22)02238-4 [pii]
AID - 10.6061/clinics/2012(09)09 [doi]
PST - ppublish
SO  - Clinics (Sao Paulo). 2012 Sep;67(9):1035-8. doi: 10.6061/clinics/2012(09)09.


PMID- 23018261
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20190608
IS  - 2329-0358 (Electronic)
IS  - 1425-9524 (Linking)
VI  - 17
IP  - 3
DP  - 2012 Jul-Sep
TI  - The attitude and knowledge of intensive care physicians and nurses regarding
      organ donation in Hungary--it needs to be changed.
PG  - 93-102
AB  - BACKGROUND: The education of intensive care professionals can influence the
      number of transplantable organs. The aim of this cross-sectional study is to
      estimate the attitude and knowledge of intensive care staff as about organ
      donation. MATERIAL/METHODS: The self-completed questionnaire was completed at the
      Congress of the Hungarian Society of Anesthesiology and Intensive Therapy in
      2011. Data, including attitudes about donation, attendance in an organ donation
      course, donation activity, self-reported knowledge of donor management,
      legislation, transplantation, and aftercare were collected from intensive care
      specialists (n=179) and nurses (n=103). RESULTS: An organ donation course was
      attended by 53.6% of physicians and 16.7% of nurses (p=0.000); the 59% of doctors
      and 64.7% of nurses who did not participate in education were not willing to do
      so. Older staff were more likely to attend the course (p<0.01). Organ donation
      activity was not influenced by age or type of staff (physician or nurse), but it 
      was higher among staff who attended training (p<0.01). Independently from
      accepting the presumed consent legislation (91.1%), 66% of intensive care
      professionals supported the practice of requesting the consent of family for
      organ retrieval. Self-reported knowledge regarding the Eurotransplant, donor
      management, the law and ethics of donation, transplantation, and after care for
      transplanted patients was influenced by age, donation activity, education, type
      of staff (p<0.01). CONCLUSIONS: Education, including knowledge concerning brain
      death, donor management and communication with family, needs to be part of the
      specialist training of intensive care professionals, with a refresher course
      every fifth year.
FAU - Smudla, Aniko
AU  - Smudla A
AD  - Department of Transplantation and Surgery, Semmelweis University, Budapest,
      Hungary. aniko_smudla@yahoo.com
FAU - Mihaly, Sandor
AU  - Mihaly S
FAU - Okros, Ilona
AU  - Okros I
FAU - Hegedus, Katalin
AU  - Hegedus K
FAU - Fazakas, Janos
AU  - Fazakas J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Transplant
JT  - Annals of transplantation
JID - 9802544
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - *Critical Care
MH  - Cross-Sectional Studies
MH  - Education, Medical, Continuing
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Hungary
MH  - Male
MH  - Middle Aged
MH  - Nursing Staff, Hospital/education
MH  - Physicians
MH  - Presumed Consent
MH  - Surveys and Questionnaires
MH  - *Tissue and Organ Procurement
EDAT- 2012/09/29 06:00
MHDA- 2013/03/13 06:00
CRDT- 2012/09/29 06:00
PHST- 2012/09/29 06:00 [entrez]
PHST- 2012/09/29 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
AID - 883463 [pii]
AID - 10.12659/aot.883463 [doi]
PST - ppublish
SO  - Ann Transplant. 2012 Jul-Sep;17(3):93-102. doi: 10.12659/aot.883463.


PMID- 23018181
OWN - NLM
STAT- MEDLINE
DCOM- 20130422
LR  - 20151119
IS  - 1529-7268 (Electronic)
IS  - 0006-3363 (Linking)
VI  - 87
IP  - 5
DP  - 2012 Nov
TI  - Viability assessment for artificial gametes: the need for biomarkers of
      functional competency.
PG  - 114
LID - 10.1095/biolreprod.112.103853 [doi]
AB  - Assisted reproductive technology (ART) has resulted in more than 5 million births
      worldwide. However, mainstream ART techniques are not always successful for an
      estimated 30% of infertile patients in whom gametes are nonviable. Most patients 
      would clearly prefer genetic parenthood, currently possible only via the use of
      donated gametes or, in future, via the clinical use of artificial gametes (AGs)
      incorporating parental DNA. Despite much recent progress in the derivation of
      AGs, significant obstacles remain. Although it is possible to create artificial
      cells exhibiting some of the molecular and physiological traits of human gametes,
      they do not yet exhibit the same level of functionality as their in vivo
      counterparts. Most current effort pays scant attention to confirmation of
      molecular integrity and clinical applicability of AGs. Here we discuss the
      various clinical parameters used to assess gamete and embryo viability and
      discuss markers of gamete function that may be used within future studies
      attempting to derive AGs. The use of AGs may prove controversial to some members 
      of the general public, and, as such, there is significant need for an appropriate
      ethical and legal framework governing the clinical use of such cells. However,
      provided these issues can be successfully overcome, it is highly likely that AGs 
      will represent powerful biological tools for reproductive science, a valuable
      training resource for embryologists and for potential use in the clinical
      treatment of human infertility.
FAU - Kashir, Junaid
AU  - Kashir J
AD  - Nuffield Department of Obstetrics and Gynaecology John Radcliffe Hospital,
      Oxford, United Kingdom.
FAU - Jones, Celine
AU  - Jones C
FAU - Child, Tim
AU  - Child T
FAU - Williams, Suzannah A
AU  - Williams SA
FAU - Coward, Kevin
AU  - Coward K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20121108
PL  - United States
TA  - Biol Reprod
JT  - Biology of reproduction
JID - 0207224
RN  - 0 (Biomarkers)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Animals
MH  - Biomarkers
MH  - Cell Survival
MH  - DNA
MH  - Epigenesis, Genetic/genetics
MH  - Female
MH  - Germ Cells/*physiology
MH  - Humans
MH  - Infertility/therapy
MH  - Male
MH  - Oocyte Donation
MH  - Oocytes/physiology
MH  - Pregnancy
MH  - *Reproductive Techniques, Assisted/ethics/trends
MH  - Spermatozoa/physiology
MH  - Tissue Donors
EDAT- 2012/09/29 06:00
MHDA- 2013/04/23 06:00
CRDT- 2012/09/29 06:00
PHST- 2012/09/29 06:00 [entrez]
PHST- 2012/09/29 06:00 [pubmed]
PHST- 2013/04/23 06:00 [medline]
AID - biolreprod.112.103853 [pii]
AID - 10.1095/biolreprod.112.103853 [doi]
PST - epublish
SO  - Biol Reprod. 2012 Nov 8;87(5):114. doi: 10.1095/biolreprod.112.103853. Print 2012
      Nov.


PMID- 23017959
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140607
LR  - 20120928
IS  - 1096-0317 (Electronic)
IS  - 0049-089X (Linking)
VI  - 41
IP  - 6
DP  - 2012 Nov
TI  - Methodological decisions and the evaluation of possible effects of different
      family structures on children: The new family structures survey (NFSS).
PG  - 1357-66
LID - 10.1016/j.ssresearch.2012.08.011 [doi]
LID - S0049-089X(12)00169-X [pii]
AB  - Every social science researcher must make a number of methodological decisions
      when planning and implementing research projects. Each such decision carries with
      it both advantages and limitations. The decisions faced and made by Regnerus
      (2012) are discussed here in the wider context of social science literature
      regarding same-sex parenting. Even though the apparent outcomes of Regnerus's
      study were unpopular, the methodological decisions he made in the design and
      implementation of the New Family Structures Survey were not uncommon among social
      scientists, including many progressive, gay and lesbian scholars. These decisions
      and the research they produced deserve considerable and continued discussion, but
      criticisms of the underlying ethics and professionalism are misplaced because
      nearly every methodological decision that was made has ample precedents in
      research published by many other credible and distinguished scholars.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Schumm, Walter R
AU  - Schumm WR
AD  - School of Family Studies and Human Services, Kansas State University, 1700
      Anderson Avenue, Manhattan, KS 66506-1403, United States. Electronic address:
      schumm@k-state.edu.
LA  - eng
PT  - Journal Article
DEP - 20120821
PL  - United States
TA  - Soc Sci Res
JT  - Social science research
JID - 0330501
EDAT- 2012/09/29 06:00
MHDA- 2012/09/29 06:01
CRDT- 2012/09/29 06:00
PHST- 2012/09/29 06:00 [entrez]
PHST- 2012/09/29 06:00 [pubmed]
PHST- 2012/09/29 06:01 [medline]
AID - S0049-089X(12)00169-X [pii]
AID - 10.1016/j.ssresearch.2012.08.011 [doi]
PST - ppublish
SO  - Soc Sci Res. 2012 Nov;41(6):1357-66. doi: 10.1016/j.ssresearch.2012.08.011. Epub 
      2012 Aug 21.


PMID- 23017620
OWN - NLM
STAT- MEDLINE
DCOM- 20131206
LR  - 20181202
IS  - 1873-6513 (Electronic)
IS  - 0885-3924 (Linking)
VI  - 45
IP  - 5
DP  - 2013 May
TI  - Family factors affect clinician attitudes in pediatric end-of-life decision
      making: a randomized vignette study.
PG  - 832-40
LID - 10.1016/j.jpainsymman.2012.05.005 [doi]
LID - S0885-3924(12)00308-9 [pii]
AB  - CONTEXT: Conflicts between families and clinicians in pediatric end-of-life (EOL)
      care cause distress for providers, dissatisfaction for patients' families, and
      potential suffering for terminally ill children. OBJECTIVES: We hypothesized that
      family factors might influence clinician decision making in these circumstances. 
      METHODS: We presented vignettes concerning difficult EOL decision making,
      randomized for religious objection to therapy withdrawal and perceived level of
      family involvement, to clinicians working in three Children's Hospital intensive 
      care units. Additionally, attitudes about EOL care were assessed. RESULTS: Three 
      hundred sixty-four respondents completed the questionnaire, for an overall
      response rate of 54%. Respondents receiving the "involved family" vignette were
      more likely to agree to continue medical care indefinitely (P<0.0005).
      Respondents were marginally more likely to pursue a court-appointed guardian for 
      those patients whose families had nonreligious objections to withdrawal (P=0.05).
      Respondents who thought that a fear of being sued affected decisions were less
      likely to pursue unilateral withdrawal (odds ratio 0.8, 95% CI=0.6-0.9). Those
      who felt personal distress as a result of difficult EOL decision making, thought 
      they often provided "futile" care, or those who felt EOL care was effectively
      addressed at the institution were less likely to want to defer to the parents'
      wishes (range of odds ratios 0.7-1). CONCLUSION: In this randomized vignette
      study, we have shown that family factors, particularly how involved a family
      seems to be in a child's life, affect what clinicians think is ethically
      appropriate in challenging EOL cases. Knowledge of how a family's degree of
      involvement may affect clinicians should be helpful to the clinical ethics
      consultants and offer some degree of insight to the clinicians themselves.
CI  - Copyright (c) 2013 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. 
      All rights reserved.
FAU - Ruppe, Michael D
AU  - Ruppe MD
AD  - Division of Critical Care Medicine, University of Louisville, Louisville,
      Kentucky, USA.
FAU - Feudtner, Chris
AU  - Feudtner C
FAU - Hexem, Kari R
AU  - Hexem KR
FAU - Morrison, Wynne E
AU  - Morrison WE
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20120925
PL  - United States
TA  - J Pain Symptom Manage
JT  - Journal of pain and symptom management
JID - 8605836
SB  - IM
MH  - Adult
MH  - Advance Care Planning/*statistics & numerical data
MH  - *Attitude of Health Personnel
MH  - Attitude to Health
MH  - *Decision Making
MH  - *Family Characteristics
MH  - Female
MH  - Humans
MH  - Legal Guardians/statistics & numerical data
MH  - Male
MH  - Middle Aged
MH  - Pediatrics/*statistics & numerical data
MH  - Physicians/*statistics & numerical data
MH  - Religion
MH  - Surveys and Questionnaires
MH  - Terminal Care/*statistics & numerical data
MH  - Terminally Ill/statistics & numerical data
MH  - United States/epidemiology
MH  - Withholding Treatment/statistics & numerical data
EDAT- 2012/09/29 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/09/29 06:00
PHST- 2012/02/15 00:00 [received]
PHST- 2012/05/08 00:00 [revised]
PHST- 2012/05/14 00:00 [accepted]
PHST- 2012/09/29 06:00 [entrez]
PHST- 2012/09/29 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - S0885-3924(12)00308-9 [pii]
AID - 10.1016/j.jpainsymman.2012.05.005 [doi]
PST - ppublish
SO  - J Pain Symptom Manage. 2013 May;45(5):832-40. doi:
      10.1016/j.jpainsymman.2012.05.005. Epub 2012 Sep 25.


PMID- 23017195
OWN - NLM
STAT- MEDLINE
DCOM- 20130529
LR  - 20121120
IS  - 1872-7727 (Electronic)
IS  - 0720-048X (Linking)
VI  - 81
IP  - 12
DP  - 2012 Dec
TI  - Age-related distribution of vertebral bone-marrow diffusivity.
PG  - 4046-9
LID - 10.1016/j.ejrad.2012.03.033 [doi]
LID - S0720-048X(12)00413-5 [pii]
AB  - PURPOSE: To determine age-related diffusivity changes of the lumbar bone marrow
      by measurement of apparent diffusion coefficient (ADC) values. MATERIALS AND
      METHODS: The local ethics committee approved this study and written informed
      consent was obtained. The study group comprised 88 individuals including 75
      healthy volunteers and 13 patients (48 female, 40 male; mean age 36 years, range 
      0-84 years). The pediatric cases were recruited from patients. Echo-planar
      diffusion weighted imaging (DWI) was performed with b-values of 50, 400 and 800
      s/mm(2). ADC-values were calculated and measured in the 1st and 2nd vertebral
      body of the lumbar spine. Correlation between age and ADC-values was analyzed
      with Spearman's rho test. RESULTS: The ADC values of the vertebral bone marrow of
      the lumbar spine showed a significant negative correlation with age (rho=-0.398, 
      p=0.001). The mean ADC values (x10(-3)mm(2)/s) in the age groups 0-29 years (mean
      age 18.0 years, n=42) and 30-88 years (mean age 51.6 years, n=46) were 0.54 +/-
      0.07 and 0.47 +/- 0.08, respectively (p<0.001, T-test). No significant
      differences were found between children and young adults. CONCLUSION: Bone marrow
      ADC values of the lumbar spine show a linear decrease with growing age and
      thereby reflect the gradual changes of cell composition occurring during marrow
      conversion.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Herrmann, Jochen
AU  - Herrmann J
AD  - Department of Diagnostic and Interventional Radiology, Martinistrasse 52, D-20246
      Hamburg, Germany. j.herrmann@uke.de
FAU - Krstin, Nina
AU  - Krstin N
FAU - Schoennagel, Bjoern P
AU  - Schoennagel BP
FAU - Sornsakrin, Marjike
AU  - Sornsakrin M
FAU - Derlin, Thorsten
AU  - Derlin T
FAU - Busch, Jasmin D
AU  - Busch JD
FAU - Petersen, Kay Uwe
AU  - Petersen KU
FAU - Graessner, Joachim
AU  - Graessner J
FAU - Adam, Gerhard
AU  - Adam G
FAU - Habermann, Christian R
AU  - Habermann CR
LA  - eng
PT  - Journal Article
DEP - 20120925
PL  - Ireland
TA  - Eur J Radiol
JT  - European journal of radiology
JID - 8106411
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*pathology
MH  - Bone Marrow/*pathology
MH  - Child
MH  - Child, Preschool
MH  - Diffusion Magnetic Resonance Imaging/*methods
MH  - Female
MH  - Humans
MH  - Image Interpretation, Computer-Assisted/*methods
MH  - Infant
MH  - Infant, Newborn
MH  - Lumbar Vertebrae/*cytology
MH  - Male
MH  - Middle Aged
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Young Adult
EDAT- 2012/09/29 06:00
MHDA- 2013/05/31 06:00
CRDT- 2012/09/29 06:00
PHST- 2012/01/20 00:00 [received]
PHST- 2012/03/06 00:00 [revised]
PHST- 2012/03/12 00:00 [accepted]
PHST- 2012/09/29 06:00 [entrez]
PHST- 2012/09/29 06:00 [pubmed]
PHST- 2013/05/31 06:00 [medline]
AID - S0720-048X(12)00413-5 [pii]
AID - 10.1016/j.ejrad.2012.03.033 [doi]
PST - ppublish
SO  - Eur J Radiol. 2012 Dec;81(12):4046-9. doi: 10.1016/j.ejrad.2012.03.033. Epub 2012
      Sep 25.


PMID- 23017005
OWN - NLM
STAT- MEDLINE
DCOM- 20130107
LR  - 20211021
IS  - 1477-7525 (Electronic)
IS  - 1477-7525 (Linking)
VI  - 10
DP  - 2012 Sep 28
TI  - Preterm children quality of life evaluation: a qualitative study to approach
      physicians' perception.
PG  - 122
LID - 10.1186/1477-7525-10-122 [doi]
AB  - BACKGROUND: While data for preterm children health-related quality of life are
      available, there are little data on the perception of health-related quality of
      life evaluation by physicians who manage preterm children, or its use in real
      life and decision making. The aim of this qualitative study is to highlight among
      physicians, themes of reflection about health-related quality of life in
      extremely preterm children (less than 28 weeks' gestation). METHODS: Focus groups
      at a French University Hospital with physicians who manage extremely preterm
      children: obstetricians, intensive care physicians, neonatal physicians and
      paediatric neurologists. The focus groups allowed the participants to discuss
      (drawing on their personal experience), three principal topics regarding the
      health-related quality of life of preterm children: representation, expectations 
      in daily practice and evaluation method. RESULTS: We included fourteen
      participants in the three focus groups. Many themes emerged from the focus
      groups: approaches for defining health-related quality of life and difficulties
      of utilization, the role that health-related quality of life should have in the
      system of care, the problem of standards and evidence-based decision making.
      Physicians had difficulties with taking positions regarding this concept. There
      were no differences by gender, age or seniority, but points of view varied by
      specialty and type of practice. Physicians who had longer specialized care for
      extremely preterm children were more sensitive to the impact of preterm
      complications on health-related quality of life. CONCLUSIONS: This study provides
      preliminary results about physicians' perspective on the health-related quality
      of life of extremely preterm children. The themes emerged from the focus groups
      are classically described in other domains but not all in so clear a way
      (definition, interests and limits, ethical reflection). This approach was never
      developed in the field of prematurity with well-knowed consequences on quality of
      life. These results require to be confirmed on a larger representative sample.
      The themes and questions of this broad opinion survey will rest on the
      information issued from our preliminary interviews.
FAU - Einaudi, Marie-Ange
AU  - Einaudi MA
AD  - Department of Neonatology, APHM, North University Hospital, Marseille, France.
      marieange.einaudi@ap-hm.fr
FAU - Simeoni, Marie-Claude
AU  - Simeoni MC
FAU - Gire, Catherine
AU  - Gire C
FAU - Le Coz, Pierre
AU  - Le Coz P
FAU - Condopoulos, Sophie
AU  - Condopoulos S
FAU - Auquier, Pascal
AU  - Auquier P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120928
PL  - England
TA  - Health Qual Life Outcomes
JT  - Health and quality of life outcomes
JID - 101153626
SB  - IM
MH  - Adult
MH  - Child
MH  - Female
MH  - Focus Groups
MH  - France
MH  - *Health Status Indicators
MH  - Humans
MH  - Male
MH  - Neurology
MH  - Outcome and Process Assessment, Health Care/*methods/standards
MH  - *Pediatrics
MH  - Physician-Patient Relations
MH  - Physicians, Family/*psychology/statistics & numerical data
MH  - Premature Birth/*therapy
MH  - Qualitative Research
MH  - *Quality of Life
MH  - Specialization
PMC - PMC3484073
EDAT- 2012/09/29 06:00
MHDA- 2013/01/08 06:00
CRDT- 2012/09/29 06:00
PHST- 2012/06/08 00:00 [received]
PHST- 2012/09/26 00:00 [accepted]
PHST- 2012/09/29 06:00 [entrez]
PHST- 2012/09/29 06:00 [pubmed]
PHST- 2013/01/08 06:00 [medline]
AID - 1477-7525-10-122 [pii]
AID - 10.1186/1477-7525-10-122 [doi]
PST - epublish
SO  - Health Qual Life Outcomes. 2012 Sep 28;10:122. doi: 10.1186/1477-7525-10-122.


PMID- 23017001
OWN - NLM
STAT- MEDLINE
DCOM- 20121120
LR  - 20220815
IS  - 0020-6539 (Print)
IS  - 0020-6539 (Linking)
VI  - 62
IP  - 4
DP  - 2012 Aug
TI  - Oral lesions associated with HIV/AIDS in HIV-seropositive patients attending a
      counselling and treatment centre in Dar es Salaam.
PG  - 197-202
LID - 10.1111/j.1875-595X.2011.00108.x [doi]
AB  - OBJECTIVE: To assess the prevalences and patterns of oral lesions occurring in
      human immunodeficiency virus (HIV) and acquired immune deficiency syndrome
      (AIDS). METHODS: A cross-sectional study was conducted among 200 people living
      with HIV/AIDS (PlwHA) who regularly attended a counselling and treatment centre
      in Dar es Salaam, Tanzania. A questionnaire-guided interview and clinical oral
      assessment were used. Strict confidentiality and adherence to ethical codes were 
      observed. RESULTS: The mean age of participants was 38.91 years (standard
      deviation: 10.424; mode: 35 years; median: 37.0 years; range: 15-76 years). Most 
      participants (58.5%) were aware of predispositions towards the occurrence of oral
      lesions such as oral candidiasis (60.0%) in HIV/AIDS and most of these (72.0%)
      were aware that the lesions are treatable. Some participants reported occurrences
      of oral thrush (22.5%) and lip ulcerations (28.5%), although only 47.0% of these 
      had sought medical advice. Examinations revealed that 29.0% of participants had
      at least one oral lesion associated with HIV/AIDS. Prevalences of the various
      types of lesion were: 11.5% for herpes simplex; 7.5% for oral candidiasis; 4.0%
      for oral hairy leukoplakia; 3.5% for Kaposi's sarcoma; 1.5% for dry mouth; 0.5%
      for angular cheilitis, and 0.5% for acute necrotising ulcerative gingivitis.
      Herpes simplex and Kaposi's sarcoma were more frequently observed in males (56.5%
      and 71.4%, respectively), whereas oral candidiasis and dry mouth were observed
      more often in females (86.7% and 66.7%, respectively) (chi(2) = 16.692, P =
      0.016). CONCLUSIONS: Prevalences of oral lesions associated with HIV/AIDS in
      PlwHA and using antiretroviral therapy are persistent, of moderate intensity and 
      vary according to individual immune status. These patients' level of awareness
      about oral lesions was satisfactory, but formal medicodental lines of management 
      were not prioritised. Contemporary protocol for the management of oral lesions
      should be understood and disseminated to the general public by dentists.
CI  - (c) 2012 FDI World Dental Federation.
FAU - Mwangosi, Ibrahim E A T
AU  - Mwangosi IE
AD  - Institute of Allied Health Sciences, Muhimbili National Hospital, Dar es Salaam, 
      Tanzania. ieatmwangosi@yahoo.com
FAU - Tillya, Jackline
AU  - Tillya J
LA  - eng
PT  - Journal Article
DEP - 20120614
PL  - England
TA  - Int Dent J
JT  - International dental journal
JID - 0374714
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/*complications
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Female
MH  - HIV Infections/*complications
MH  - HIV Seropositivity/*complications
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mouth Diseases/*complications/diagnosis
MH  - Tanzania
MH  - Young Adult
PMC - PMC9374901
EDAT- 2012/09/29 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/09/29 06:00
PHST- 2012/09/29 06:00 [entrez]
PHST- 2012/09/29 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1111/j.1875-595X.2011.00108.x [doi]
PST - ppublish
SO  - Int Dent J. 2012 Aug;62(4):197-202. doi: 10.1111/j.1875-595X.2011.00108.x. Epub
      2012 Jun 14.


PMID- 23016663
OWN - NLM
STAT- MEDLINE
DCOM- 20130211
LR  - 20211021
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 13
DP  - 2012 Sep 27
TI  - Procedure versus process: ethical paradigms and the conduct of qualitative
      research.
PG  - 25
LID - 10.1186/1472-6939-13-25 [doi]
AB  - BACKGROUND: Research is fundamental to improving the quality of health care. The 
      need for regulation of research is clear. However, the bureaucratic complexity of
      research governance has raised concerns that the regulatory mechanisms intended
      to protect participants now threaten to undermine or stifle the research
      enterprise, especially as this relates to sensitive topics and hard to reach
      groups. DISCUSSION: Much criticism of research governance has focused on long
      delays in obtaining ethical approvals, restrictions imposed on study conduct, and
      the inappropriateness of evaluating qualitative studies within the methodological
      and risk assessment frameworks applied to biomedical and clinical research. Less 
      attention has been given to the different epistemologies underlying biomedical
      and qualitative investigation. The bioethical framework underpinning current
      regulatory structures is fundamentally at odds with the practice of emergent,
      negotiated micro-ethics required in qualitative research. The complex and
      shifting nature of real world settings delivers unanticipated ethical issues and 
      (occasionally) genuine dilemmas which go beyond easy or formulaic 'procedural'
      resolution. This is not to say that qualitative studies are 'unethical' but that 
      their ethical nature can only be safeguarded through the practice of
      'micro-ethics' based on the judgement and integrity of researchers in the field. 
      SUMMARY: This paper considers the implications of contrasting ethical paradigms
      for the conduct of qualitative research and the value of 'empirical ethics' as a 
      means of liberating qualitative (and other) research from an outmoded and unduly 
      restrictive research governance framework based on abstract prinicipalism,
      divorced from real world contexts and values.
FAU - Pollock, Kristian
AU  - Pollock K
AD  - School of Nursing, Midwifery and Physiotherapy, University of Nottingham, Queen's
      Medical Centre, Derby Road, Nottingham NG7 2HA, UK.
      kristian.pollock@nottingham.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20120927
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Altruism
MH  - Beneficence
MH  - Confidentiality/ethics
MH  - Ethics, Research
MH  - *Government Regulation
MH  - Health Services Research/*ethics
MH  - Humans
MH  - Informed Consent/ethics
MH  - Moral Obligations
MH  - *Morals
MH  - Palliative Care/ethics
MH  - *Personal Autonomy
MH  - *Qualitative Research
MH  - Research Personnel/*ethics
MH  - *Research Subjects
MH  - Social Justice
MH  - Terminal Care/ethics
PMC - PMC3519630
EDAT- 2012/09/29 06:00
MHDA- 2013/02/12 06:00
CRDT- 2012/09/29 06:00
PHST- 2012/05/17 00:00 [received]
PHST- 2012/09/18 00:00 [accepted]
PHST- 2012/09/29 06:00 [entrez]
PHST- 2012/09/29 06:00 [pubmed]
PHST- 2013/02/12 06:00 [medline]
AID - 1472-6939-13-25 [pii]
AID - 10.1186/1472-6939-13-25 [doi]
PST - epublish
SO  - BMC Med Ethics. 2012 Sep 27;13:25. doi: 10.1186/1472-6939-13-25.


PMID- 23016511
OWN - NLM
STAT- MEDLINE
DCOM- 20150701
LR  - 20211021
IS  - 1369-7625 (Electronic)
IS  - 1369-6513 (Linking)
VI  - 17
IP  - 6
DP  - 2014 Dec
TI  - Lay people's interpretation of ethical values related to mass vaccination; the
      case of A(H1N1) vaccination campaign in the province of Quebec (French Canada).
PG  - 876-87
LID - 10.1111/hex.12005 [doi]
AB  - BACKGROUND: Pandemic influenza ethics frameworks are based on respect of values
      and principles such as regard for autonomy, responsibility, transparency,
      solidarity and social justice. However, very few studies have addressed the way
      in which the general population views these moral norms. OBJECTIVES: (i) To
      analyse the receptiveness of the population of French-speaking Quebecers to
      certain ethical principles promoted by public health authorities during the AH1N1
      vaccination campaign. (ii) To add to the limited number of empirical studies that
      examine the population's perception of ethical values. DESIGN: Eight months after
      the end of the AH1N1 vaccination campaign in the Province of Quebec (Canada), 100
      French-speaking Quebecers were assembled in ten focus groups. Discussions
      focussed on the level of respect shown by public health authorities for
      individual autonomy, the limits of appeals for solidarity, the balance between
      vaccination efficiency and social justice towards non-prioritized subpopulations,
      vaccination as a demonstration of civic duty and social responsibility. RESULTS: 
      The population acknowledged a high level of individual responsibility towards
      family members and agreed to vaccination to protect children and ageing parents. 
      However, the concepts of civic duty and solidarity did not elucidate unanimous
      support, despite the fact that social justice stood out as a dominant value of
      public morals. CONCLUSION: The ethical principles promoted in influenza pandemic 
      ethics frameworks are subject to reinterpretation by the population. An ethic of 
      public health must consider their understanding of the fundamental values that
      legitimize mass vaccination.
CI  - (c) 2012 John Wiley & Sons Ltd.
FAU - Masse, Raymond
AU  - Masse R
AD  - Department of Anthropology, Laval University, Quebec City, QC, Canada.
FAU - Desy, Michel
AU  - Desy M
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120928
PL  - England
TA  - Health Expect
JT  - Health expectations : an international journal of public participation in health 
      care and health policy
JID - 9815926
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Female
MH  - Focus Groups
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - *Influenza A Virus, H1N1 Subtype
MH  - Influenza, Human/*prevention & control
MH  - Male
MH  - Mass Vaccination/*ethics
MH  - Middle Aged
MH  - Quebec
MH  - *Social Responsibility
MH  - Young Adult
PMC - PMC5060925
OTO - NOTNLM
OT  - AH1N1
OT  - Canada
OT  - ethical values
OT  - ethics
OT  - lay perceptions
OT  - vaccination
EDAT- 2012/09/29 06:00
MHDA- 2015/07/02 06:00
CRDT- 2012/09/29 06:00
PHST- 2012/08/25 00:00 [accepted]
PHST- 2012/09/29 06:00 [entrez]
PHST- 2012/09/29 06:00 [pubmed]
PHST- 2015/07/02 06:00 [medline]
AID - 10.1111/hex.12005 [doi]
PST - ppublish
SO  - Health Expect. 2014 Dec;17(6):876-87. doi: 10.1111/hex.12005. Epub 2012 Sep 28.


PMID- 23016095
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120928
LR  - 20211021
IS  - 1941-0921 (Electronic)
IS  - 1941-0921 (Linking)
VI  - 4
IP  - 3
DP  - 2012 May
TI  - Mesenchymal stem cell therapy in the sports knee: where are we in 2011?
PG  - 252-7
AB  - BACKGROUND: The relationship between biological tissue healing following knee
      injury or surgery and long-term clinical outcome has come to the forefront of
      sports medicine practice. This has led many knee surgeons to incorporate
      biologically mediated healing factors into the management of knee injuries. In
      particular, the clinical use of mesenchymal stem cells has opened new horizons.
      EVIDENCE ACQUISITION: Relevant studies were identified through a search of PubMed
      from January 2000 to April 2011, combining the term mesenchymal stem cells with
      articular cartilage, anterior cruciate ligament, and meniscus. Relevant citations
      from the reference lists of selected studies were also reviewed. RESULTS: Knee
      injury treatment with mesenchymal stem cells shows potential. Most reports
      represent animal model studies; few advances have been translated to human
      clinical applications. CONCLUSION: Mesenchymal stem cell use to promote healing
      following knee injury is likely to increase. There are scientific methodological 
      concerns and ethical and legal issues regarding mesenchymal stem cell use for
      treating knee injuries.
FAU - Dave, Lee Yee Han
AU  - Dave LY
AD  - Department of Orthopaedic Surgery, University of Louisville, Louisville,
      Kentucky.
FAU - Nyland, John
AU  - Nyland J
FAU - McKee, Paul B
AU  - McKee PB
FAU - Caborn, David N M
AU  - Caborn DN
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Sports Health
JT  - Sports health
JID - 101518422
PMC - PMC3435924
OTO - NOTNLM
OT  - biological tissue healing
OT  - cartilage repair
OT  - cell-based therapy
EDAT- 2012/09/28 06:00
MHDA- 2012/09/28 06:01
CRDT- 2012/09/28 06:00
PHST- 2012/09/28 06:00 [entrez]
PHST- 2012/09/28 06:00 [pubmed]
PHST- 2012/09/28 06:01 [medline]
AID - 10.1177/1941738111427250 [doi]
AID - 10.1177_1941738111427250 [pii]
PST - ppublish
SO  - Sports Health. 2012 May;4(3):252-7. doi: 10.1177/1941738111427250.


PMID- 23015747
OWN - NLM
STAT- MEDLINE
DCOM- 20130325
LR  - 20181202
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 2
DP  - 2013 Feb
TI  - Ethics and eplerenone.
PG  - 110-4
LID - 10.1136/medethics-2011-100258 [doi]
AB  - The use of a placebo arm in clinical trials is unethical if there is an active
      comparator that is acceptably safe and effective. We argue that reasonable
      evidence of effectiveness and safety of an inexpensive alternative to an
      expensive therapy is sufficient to require that the inexpensive therapy be
      included as a comparator when the expensive therapy is tested, and that use of an
      inactive placebo comparator only is not ethical. For example, studies of the
      expensive drug eplerenone for congestive heart failure have not included a
      spironolactone arm, although there is reasonable evidence that spironolactone
      would be safe and effective, and spironolactone is inexpensive. The requirement
      to study inexpensive therapies is based on avoidance of unnecessary cost in
      medical care as an example of non-maleficence. Several ethical actors in the
      design, conduct, and publication of clinical trials and their results bear
      responsibility for the appropriate conduct of clinical trials. That
      responsibility includes protecting study subjects from being asked to participate
      in clinical trials that serve primarily to promote the use of new and expensive
      therapies.
FAU - Gupta, Shruti
AU  - Gupta S
AD  - Department of Pharmacology and Physiology, Georgetown University Medical Center, 
      Washington DC, USA.
FAU - Fugh-Berman, Adriane J
AU  - Fugh-Berman AJ
FAU - Scialli, Anthony
AU  - Scialli A
LA  - eng
PT  - Journal Article
DEP - 20120926
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
RN  - 0 (Mineralocorticoid Receptor Antagonists)
RN  - 0 (Placebos)
RN  - 27O7W4T232 (Spironolactone)
RN  - 6995V82D0B (Eplerenone)
SB  - IM
MH  - Clinical Trials as Topic/*ethics
MH  - Cost-Benefit Analysis
MH  - *Drug Costs/ethics
MH  - Eplerenone
MH  - Ethics Committees, Research
MH  - Ethics, Research
MH  - Heart Failure/diagnosis/*drug therapy
MH  - Humans
MH  - Mineralocorticoid Receptor Antagonists/*economics/therapeutic use
MH  - Periodicals as Topic
MH  - *Placebos
MH  - Research Personnel
MH  - Severity of Illness Index
MH  - Spironolactone/*analogs & derivatives/*economics/therapeutic use
MH  - Therapeutic Equipoise
MH  - Treatment Outcome
MH  - United States
MH  - United States Food and Drug Administration
EDAT- 2012/09/28 06:00
MHDA- 2013/03/26 06:00
CRDT- 2012/09/28 06:00
PHST- 2012/09/28 06:00 [entrez]
PHST- 2012/09/28 06:00 [pubmed]
PHST- 2013/03/26 06:00 [medline]
AID - medethics-2011-100258 [pii]
AID - 10.1136/medethics-2011-100258 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Feb;39(2):110-4. doi: 10.1136/medethics-2011-100258. Epub 2012
      Sep 26.


PMID- 23015727
OWN - NLM
STAT- MEDLINE
DCOM- 20121228
LR  - 20151119
IS  - 2042-7670 (Electronic)
IS  - 0042-4900 (Linking)
VI  - 171
IP  - 18
DP  - 2012 Nov 3
TI  - Care and Justice orientations to moral decision making in veterinary students.
PG  - 446
LID - 10.1136/vr.101003 [doi]
AB  - An adapted version of the Moral Justification Scale was used to assess moral
      decision-making orientation in veterinary students, comparing sex and year of
      study. The Scale consists of vignettes and related statements, each of which was 
      classified as Justice, Care for People or Care for Animals. The importance of
      each statement in the decision-making process was rated by 204 students on a
      10-point Likert Scale. An average score of importance for Justice, Care for
      People and Care for Animals related statements were calculated for each
      individual. General inclination scores were calculated by subtracting an
      individual's average Care score from their average Justice score. Inclination
      scores suggested that two-thirds of students have a balanced approach, using
      Justice and Care almost equally in approaching ethical dilemmas. The majority of 
      students, however, show an overall Justice orientation. The attitude towards the 
      importance of Justice did not vary between students of different years or sexes. 
      Students' attitudes towards the importance of Care for People in their decision
      making were, however, significantly lower for final-year students. Reasons
      hypothesised include the start of placements. Care for Animals scores were
      affected by sex, whereby females give more importance to such statements than
      males.
FAU - Quinn, C
AU  - Quinn C
AD  - Manor Veterinary Clinic, Pent Road, Shearway Business Park, Folkestone, Kent CT19
      4RH, UK.
FAU - Kinnison, T
AU  - Kinnison T
FAU - May, S A
AU  - May SA
LA  - eng
PT  - Journal Article
DEP - 20120926
PL  - England
TA  - Vet Rec
JT  - The Veterinary record
JID - 0031164
SB  - IM
CIN - Vet Rec. 2012 Nov 3;171(18):443-4. PMID: 23125264
MH  - Adult
MH  - *Decision Making
MH  - Ethics, Medical/*education
MH  - Female
MH  - Humans
MH  - Male
MH  - Moral Development
MH  - Morals
MH  - Psychometrics
MH  - Sex Distribution
MH  - Social Responsibility
MH  - Students/*psychology
MH  - Surveys and Questionnaires
MH  - Veterinary Medicine/*ethics
MH  - Young Adult
EDAT- 2012/09/28 06:00
MHDA- 2012/12/29 06:00
CRDT- 2012/09/28 06:00
PHST- 2012/09/28 06:00 [entrez]
PHST- 2012/09/28 06:00 [pubmed]
PHST- 2012/12/29 06:00 [medline]
AID - vr.101003 [pii]
AID - 10.1136/vr.101003 [doi]
PST - ppublish
SO  - Vet Rec. 2012 Nov 3;171(18):446. doi: 10.1136/vr.101003. Epub 2012 Sep 26.


PMID- 23015599
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 5
DP  - 2012
TI  - Effectiveness of telemedicine and distance learning applications for patients
      with chronic heart failure. A protocol for prospective parallel group
      non-randomised open label study.
LID - 10.1136/bmjopen-2012-001346 [doi]
LID - e001346 [pii]
AB  - INTRODUCTION: Chronic heart failure in Baltic Sea Region is responsible for more 
      hospitalisations than all forms of cancer combined and is one of the leading
      causes of hospitalisations in elderly patients. Frequent hospitalisations, along 
      with other direct and indirect costs, place financial burden on healthcare
      systems. We aim to test the hypothesis that telemedicine and distance learning
      applications is superior to the current standard of home care. METHODS AND
      ANALYSIS: Prospective parallel group non-randomised open label study in patients 
      with New York Heart Association (NYHA) II-III chronic heart failure will be
      carried out in six Baltic Sea Region countries. The study is organised into two
      6-month follow-up periods. The first 6-month period is based on active
      implementation of tele-education and/or telemedicine for patients in two groups
      (active run period) and one standard care group (passive run period). The second 
      6-month period of observation will be based on standard care model (passive run
      period) to all three groups. Our proposed practice change is based on
      translational research with empirically supported interventions brought to
      practice and aims to find the home care model that is most effective to patient
      needs. ETHICS AND DISSEMINATION: This study has been approved by National
      Bioethics Committee (2011-03-07; Registration No: BE-2-11). TRIAL REGISTRATION:
      This study has been registered in Australian New Zealand Clinical Trials Registry
      (ANZCTR) with registration number ACTRN12611000834954.
FAU - Vanagas, Giedrius
AU  - Vanagas G
AD  - Department of Preventive Medicine, Lithuanian University of Health Sciences,
      Kaunas, Lithuania.
FAU - Umbrasiene, Jelena
AU  - Umbrasiene J
FAU - Slapikas, Rimvydas
AU  - Slapikas R
CN  - ICT for Health project workgroup
LA  - eng
PT  - Journal Article
DEP - 20120925
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3467609
EDAT- 2012/09/28 06:00
MHDA- 2012/09/28 06:01
CRDT- 2012/09/28 06:00
PHST- 2012/09/28 06:00 [entrez]
PHST- 2012/09/28 06:00 [pubmed]
PHST- 2012/09/28 06:01 [medline]
AID - bmjopen-2012-001346 [pii]
AID - 10.1136/bmjopen-2012-001346 [doi]
PST - epublish
SO  - BMJ Open. 2012 Sep 25;2(5). pii: bmjopen-2012-001346. doi:
      10.1136/bmjopen-2012-001346. Print 2012.


PMID- 23015470
OWN - NLM
STAT- MEDLINE
DCOM- 20130308
LR  - 20130116
IS  - 1545-5017 (Electronic)
IS  - 1545-5009 (Linking)
VI  - 60
IP  - 3
DP  - 2013 Mar
TI  - Parental informed consent in pediatric cancer trials: a population-based survey
      in Germany.
PG  - 446-50
LID - 10.1002/pbc.24330 [doi]
AB  - BACKGROUND: Ensuring adequate parental consent is a key issue of ethical practice
      in pediatric oncology. In Germany, however, knowledge about parental
      comprehension and satisfaction with the informed consent procedure is limited,
      and representative data on parents' perspectives are still missing. Based on data
      collected by means of a population-based survey, we evaluated the parental recall
      of the informed consent process for pediatric clinical trials, and how they rated
      the consent process retrospectively. PROCEDURE: A standardized survey was carried
      out among 1,465 parents whose children were first diagnosed in 2005 with a
      disease defined by ICCC-3 in the German Childhood Cancer Registry (response:
      55.1%). The survey's primary objective was to assess how well parents were able
      to recall of the informed consent process. To evaluate the results, we set up a
      second survey among 581 parents who had given consent recently for their child's 
      participation in a clinical trial (response: 53.5%). RESULTS: Approximately 81%
      of the parents in the population-based survey correctly remembered whether or not
      their child had been enrolled in a clinical trial or treated off-trial. The
      ability to recall accurately is significantly lower if the parents have a
      migration background or if their child was not a trial participant. However,
      parents who recalled the child's trial participation status incorrectly felt as
      adequately informed as parents who recalled it correctly. CONCLUSIONS: Our
      results identified weak points and vulnerable subgroups in the parental consent
      process in pediatric oncology in Germany.
CI  - Copyright (c) 2012 Wiley Periodicals, Inc.
FAU - Petersen, Imme
AU  - Petersen I
AD  - University of Hamburg, Research Centre for Biotechnology, Society and the
      Environment, 22529 Hamburg, Germany. imme.petersen@uni-hamburg.de
FAU - Spix, Claudia
AU  - Spix C
FAU - Kaatsch, Peter
AU  - Kaatsch P
FAU - Graf, Norbert
AU  - Graf N
FAU - Janka, Gritta
AU  - Janka G
FAU - Kollek, Regine
AU  - Kollek R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120926
PL  - United States
TA  - Pediatr Blood Cancer
JT  - Pediatric blood & cancer
JID - 101186624
SB  - IM
MH  - Clinical Trials as Topic
MH  - Comprehension
MH  - Data Collection
MH  - Germany
MH  - Humans
MH  - Neoplasms/*therapy
MH  - *Parental Consent
MH  - Parents
EDAT- 2012/09/28 06:00
MHDA- 2013/03/09 06:00
CRDT- 2012/09/28 06:00
PHST- 2012/03/22 00:00 [received]
PHST- 2012/08/23 00:00 [accepted]
PHST- 2012/09/28 06:00 [entrez]
PHST- 2012/09/28 06:00 [pubmed]
PHST- 2013/03/09 06:00 [medline]
AID - 10.1002/pbc.24330 [doi]
PST - ppublish
SO  - Pediatr Blood Cancer. 2013 Mar;60(3):446-50. doi: 10.1002/pbc.24330. Epub 2012
      Sep 26.


PMID- 23015389
OWN - NLM
STAT- MEDLINE
DCOM- 20130225
LR  - 20130319
IS  - 1471-2857 (Electronic)
IS  - 0957-9664 (Linking)
VI  - 22
IP  - 4
DP  - 2012 Oct
TI  - The treating psychiatrist as expert in the courts: is it necessary or possible to
      separate the roles of physician and expert?
PG  - 271-92
LID - 10.1002/cbm.1843 [doi]
AB  - BACKGROUND: Certified medical specialists, including forensic psychiatrists, from
      the 27 member states of the European Union (EU) may practise in each other's
      countries, but there are professional and legal differences between them. One may
      lie in whether a patient's treating doctor/clinician may give expert evidence
      about that person in court. AIMS: To examine similarities and differences between
      EU jurisdictions in law and practice in combining or separating such roles and to
      review the evidence in support of either position. METHODS: A psychiatrist with
      court experience was contacted in each EU country about law, practice and
      guidance on division of clinician-expert roles. Published literature was searched
      for an evidence base for practice in the field. Additional material is from
      discussion at a residential meeting of practising forensic psychiatrists from
      Austria, Belgium, Denmark, Germany, Hungary, the Netherlands, Switzerland and the
      UK. RESULTS: All acknowledge that a treating clinician can never be an
      independent expert in that case, but the 22 (of 27) EU countries responding vary 
      in law and practice on whether the dual role may be assumed. There has been
      almost no research interest in factors relevant to separation of roles.
      International discussion revealed that ethical and practice issues are not
      straightforward. CONCLUSIONS: On current evidence, either separation or
      combination of clinical and expert roles in a particular case may be acceptable. 
      Insofar as there are national legal or professional guidelines on this issue,
      anyone practising in that country must follow them and may safely do so,
      regardless of practice in their native country. The most important ethical issue 
      lies in clarity for all parties on the nature and extent of roles in the case.
      This paper has additional material online.
CI  - Copyright (c) 2012 John Wiley & Sons, Ltd.
FAU - Taylor, Pamela J
AU  - Taylor PJ
AD  - School of Medicine, Cardiff University, Cardiff, UK. taylorpj2@cardiff.ac.uk
FAU - Graf, Marc
AU  - Graf M
FAU - Schanda, Hans
AU  - Schanda H
FAU - Vollm, Birgit
AU  - Vollm B
LA  - eng
PT  - Journal Article
PL  - England
TA  - Crim Behav Ment Health
JT  - Criminal behaviour and mental health : CBMH
JID - 9309668
SB  - IM
CIN - Crim Behav Ment Health. 2013 Feb;23(1):72-3. PMID: 23355505
MH  - Criminal Law
MH  - Europe
MH  - Expert Testimony/*legislation & jurisprudence
MH  - Forensic Psychiatry/*legislation & jurisprudence
MH  - Humans
MH  - *Physicians
EDAT- 2012/09/28 06:00
MHDA- 2013/02/26 06:00
CRDT- 2012/09/28 06:00
PHST- 2012/09/28 06:00 [entrez]
PHST- 2012/09/28 06:00 [pubmed]
PHST- 2013/02/26 06:00 [medline]
AID - 10.1002/cbm.1843 [doi]
PST - ppublish
SO  - Crim Behav Ment Health. 2012 Oct;22(4):271-92. doi: 10.1002/cbm.1843.


PMID- 23015388
OWN - NLM
STAT- MEDLINE
DCOM- 20130225
LR  - 20131106
IS  - 1471-2857 (Electronic)
IS  - 0957-9664 (Linking)
VI  - 22
IP  - 4
DP  - 2012 Oct
TI  - Selling forensic psychiatry: recruiting for the future, establishing services.
PG  - 261-70
LID - 10.1002/cbm.1841 [doi]
AB  - BACKGROUND AND AIM: The Ghent Group - a group of European forensic psychiatrists 
      - has discussed ways of informing fellow professionals and the wider public about
      their difficult and frequently misunderstood discipline, agreeing that the
      specialty may have to be 'sold' to those who pay for it and use it. Our aim was
      to consider the areas where this commonly occurs and the strengths and pitfalls
      of such promotion. DISCUSSION: Forensic psychiatrists need to be effective,
      accurate communicators. For court work, they need special training. High
      standards of work are the best selling technique. Outside court, the greatest
      challenge for forensic psychiatry is to reduce its stigma - it can easily be
      construed, wrongly, as excusing serious anti-social behaviour. Special attention 
      should be given to writing for a wider audience, not just the inner circle of
      practitioners. Electronic social media should also be deployed for this task.
      Those who provide funds for academic work should be specifically but differently 
      targeted. They need to be persuaded of the scientific merit of the subject.
      ETHICS: Temptation to claim more for the discipline than can be justified have to
      be resisted. An English case that led to a miscarriage of justice illustrates
      this. The limitations of science here have to be understood. Philosophical
      questions relating to responsibility and culpability cannot be resolved by
      physical science alone. Misuse neuroimaging in court, for example, can lead to
      miscarriages of justice. CONCLUSION: Selling forensic psychiatry to public and
      professionals is difficult but essential to counter anti-forensic psychiatry
      movements that have emerged. The discipline needs to persuade others of its
      unique skills and embrace good science, compassion, public duty and ethical
      practice. It needs to treat with politicians and funders as well as the medical, 
      psychological and legal professions.
CI  - Copyright (c) 2012 John Wiley & Sons, Ltd.
FAU - Goethals, Kris
AU  - Goethals K
AD  - University Forensic Centre, Antwerp University Hospital, Edegem, Belgium.
      kris.goethals@uza.be
FAU - Gunn, John
AU  - Gunn J
FAU - Calcedo-Barba, Alfredo
AU  - Calcedo-Barba A
LA  - eng
PT  - Journal Article
PL  - England
TA  - Crim Behav Ment Health
JT  - Criminal behaviour and mental health : CBMH
JID - 9309668
SB  - IM
MH  - *Ethics, Medical
MH  - Expert Testimony
MH  - Forensic Psychiatry/*education/*legislation & jurisprudence
MH  - Humans
MH  - Social Justice
EDAT- 2012/09/28 06:00
MHDA- 2013/02/26 06:00
CRDT- 2012/09/28 06:00
PHST- 2012/09/28 06:00 [entrez]
PHST- 2012/09/28 06:00 [pubmed]
PHST- 2013/02/26 06:00 [medline]
AID - 10.1002/cbm.1841 [doi]
PST - ppublish
SO  - Crim Behav Ment Health. 2012 Oct;22(4):261-70. doi: 10.1002/cbm.1841.


PMID- 23014383
OWN - NLM
STAT- MEDLINE
DCOM- 20130403
LR  - 20120927
IS  - 1476-5543 (Electronic)
IS  - 0743-8346 (Linking)
VI  - 32
IP  - 10
DP  - 2012 Oct
TI  - Ethics of emerging technologies and their transition to accepted practice:
      intestinal transplant for short bowel syndrome.
PG  - 752-6
LID - 10.1038/jp.2012.69 [doi]
AB  - Parental counseling becomes complex when considering the use of emerging
      technologies, especially if it is unclear whether the level of evidence is
      sufficient to transform the proposed therapy into accepted practice. This paper
      addresses ethical issues underlying medical decision-making and counseling in the
      setting of emerging treatments, when long-term outcomes are still in the process 
      of being fully validated. We argue that the ethical transition of emerging
      technologies, ideally from ethically impermissible to permissible, to obligatory,
      depends primarily on two factors: outcome data (or prognosis) and treatment
      feasibility. To illustrate these points, we will use intestinal transplant for
      short bowel syndrome (SBS) as a specific example. After reviewing the data, this 
      paper will identify the ethical justifications for both comfort care only and
      intestinal transplant in patients with ultra SBS, and argue that both are
      ethically permissible, but neither is obligatory. The approach outlined will not 
      only be valuable as ultra SBS outcomes data continue to change, but will also be 
      applicable to other novel therapies as they emerge in perinatal medicine.
FAU - Cummings, C L
AU  - Cummings CL
AD  - Division of Neonatal-Perinatal Medicine, Yale University School of Medicine, New 
      Haven, CT 06520-8064, USA. Christy.Cummings@yale.edu
FAU - Mercurio, M R
AU  - Mercurio MR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Perinatol
JT  - Journal of perinatology : official journal of the California Perinatal
      Association
JID - 8501884
SB  - IM
MH  - Adult
MH  - Biomedical Technology/*ethics
MH  - Counseling
MH  - *Decision Making
MH  - *Ethics, Medical
MH  - Humans
MH  - Infant, Newborn
MH  - Informed Consent
MH  - Intestine, Small/*transplantation
MH  - Organ Transplantation/*ethics
MH  - Palliative Care
MH  - Parents
MH  - Prognosis
MH  - Short Bowel Syndrome/*surgery
MH  - Treatment Outcome
EDAT- 2012/09/28 06:00
MHDA- 2013/04/04 06:00
CRDT- 2012/09/28 06:00
PHST- 2012/09/28 06:00 [entrez]
PHST- 2012/09/28 06:00 [pubmed]
PHST- 2013/04/04 06:00 [medline]
AID - jp201269 [pii]
AID - 10.1038/jp.2012.69 [doi]
PST - ppublish
SO  - J Perinatol. 2012 Oct;32(10):752-6. doi: 10.1038/jp.2012.69.


PMID- 23013404
OWN - NLM
STAT- MEDLINE
DCOM- 20130108
LR  - 20211021
IS  - 1477-7525 (Electronic)
IS  - 1477-7525 (Linking)
VI  - 10
DP  - 2012 Sep 26
TI  - A pilot randomized controlled trial of the feasibility of a self-directed coping 
      skills intervention for couples facing prostate cancer: rationale and design.
PG  - 119
LID - 10.1186/1477-7525-10-119 [doi]
AB  - BACKGROUND: Although it is known both patients' and partners' reactions to a
      prostate cancer diagnosis include fear, uncertainty, anxiety and depression with 
      patients' partners' reactions mutually determining how they cope with and adjust 
      to the illness, few psychosocial interventions target couples. Those that are
      available tend to be led by highly trained professionals, limiting their
      accessibility and long-term sustainability. In addition, it is recognised that
      patients who might benefit from conventional face-to-face psychosocial
      interventions do not access these, either by preference or because of
      geographical or mobility barriers. Self-directed interventions can overcome some 
      of these limitations and have been shown to contribute to patient well-being.
      This study will examine the feasibility of a self-directed, coping skills
      intervention for couples affected by cancer, called Coping-Together, and begin to
      explore its potential impact on couples' illness adjustment. The pilot version of
      Coping-Together includes a series of four booklets, a DVD, and a relaxation audio
      CD. METHODS/DESIGN: In this double-blind, two-group, parallel, randomized
      controlled trial, 70 couples will be recruited within 4 months of a prostate
      cancer diagnosis through urology private practices and randomized to: 1)
      Coping-Together or 2) a minimal ethical care condition. Minimal ethical care
      condition couples will be mailed information booklets available at the Cancer
      Council New South Wales and a brochure for the Cancer Council Helpline. The
      primary outcome (anxiety) and additional secondary outcomes (distress,
      depression, dyadic adjustment, quality of life, illness or caregiving appraisal, 
      self-efficacy, and dyadic and individual coping) will be assessed at baseline
      (before receiving study material) and 2 months post-baseline. Intention-to-treat 
      and per protocol analysis will be conducted. DISCUSSION: As partners' distress
      rates exceed not only population norms, but also those reported by patients
      themselves, it is imperative that coping skills interventions target the couple
      as a unit and enhance both partners' ability to overcome cancer challenges. This 
      pilot study will examine the feasibility and potential efficacy of
      Coping-Together in optimising couples' illness adjustment. This is one of the
      first feasibility studies to test this innovative coping intervention, which in
      turn will contribute to the larger literature advocating for psychosocial care of
      couples affected by prostate cancer. TRIAL REGISTRATION: Australian New Zealand
      Clinical Trials Registry ACTRN12611000438954.
FAU - Lambert, Sylvie D
AU  - Lambert SD
AD  - Translational Cancer Research Unit, Ingham Institute for Applied Medical
      Research, South Western Sydney Clinical School, UNSW Medicine, The University of 
      New South Wales, Liverpool, BC NSW, 2170, Australia.
FAU - Girgis, Afaf
AU  - Girgis A
FAU - Turner, Jane
AU  - Turner J
FAU - McElduff, Patrick
AU  - McElduff P
FAU - Kayser, Karen
AU  - Kayser K
FAU - Vallentine, Paula
AU  - Vallentine P
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20120926
PL  - England
TA  - Health Qual Life Outcomes
JT  - Health and quality of life outcomes
JID - 101153626
SB  - IM
MH  - *Adaptation, Psychological
MH  - Double-Blind Method
MH  - Feasibility Studies
MH  - Female
MH  - Health Education
MH  - Hotlines
MH  - Humans
MH  - Male
MH  - New South Wales
MH  - Outcome Assessment, Health Care/methods
MH  - Pamphlets
MH  - Pilot Projects
MH  - Problem Solving
MH  - Prostatic Neoplasms/diagnosis/*psychology
MH  - Psychometrics
MH  - Research Design
MH  - Self Care/*methods
MH  - *Social Support
MH  - Spouses/education/*psychology
MH  - Stress, Psychological/diagnosis/prevention & control
MH  - Treatment Outcome
PMC - PMC3489876
EDAT- 2012/09/28 06:00
MHDA- 2013/01/09 06:00
CRDT- 2012/09/28 06:00
PHST- 2012/04/17 00:00 [received]
PHST- 2012/09/17 00:00 [accepted]
PHST- 2012/09/28 06:00 [entrez]
PHST- 2012/09/28 06:00 [pubmed]
PHST- 2013/01/09 06:00 [medline]
AID - 1477-7525-10-119 [pii]
AID - 10.1186/1477-7525-10-119 [doi]
PST - epublish
SO  - Health Qual Life Outcomes. 2012 Sep 26;10:119. doi: 10.1186/1477-7525-10-119.


PMID- 23012464
OWN - NLM
STAT- MEDLINE
DCOM- 20130211
LR  - 20140731
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 265
IP  - 3
DP  - 2012 Dec
TI  - Coil-treated aneurysms: decision making regarding additional treatment based on
      findings of MR angiography and intraarterial DSA.
PG  - 858-63
LID - 10.1148/radiol.12112608 [doi]
AB  - PURPOSE: To assess whether magnetic resonance (MR) angiography can be used as a
      noninvasive alternative to intraarterial digital subtraction angiography (DSA) to
      indicate additional treatment in the follow-up of patients with coil-treated
      intracranial aneurysms. MATERIALS AND METHODS: This was an ethics
      committee-approved multicenter study. Consecutive patients who were scheduled for
      follow-up intraarterial DSA after coil placement were invited for additional MR
      angiography after providing written informed consent. Interventional
      neuroradiologists gave treatment advice (additional treatment, extended follow-up
      imaging, or discharge from follow-up) for each imaging modality. Agreement
      between treatment advices based on intraarterial DSA and MR angiographic findings
      and interobserver agreement were assessed with weighted kappa statistics.
      RESULTS: Agreement between intraarterial DSA- and MR angiography-based treatment 
      recommendations was substantial (kappa = 0.73; 95% confidence interval [CI]:
      0.66, 0.80). In 34 of the 310 patients (11%), the advice was additional treatment
      based on findings of both modalities. In six patients (2%), the advice based on
      intraarterial DSA findings was additional treatment, while that based on MR
      angiographic findings was extended follow-up imaging; therefore, none of these
      patients were discharged from follow-up on the basis of MR angiographic findings.
      In six other patients (2%), the advice based on MR angiographic findings was
      additional treatment, while that based on intraarterial DSA findings was extended
      follow-up imaging (four patients), discharge from follow-up (one patient), and
      noninterpretable DSA (one patient). Extended follow-up imaging was suggested for 
      37 patients (12%) after intraarterial DSA and for 49 patients (16%) after MR
      angiography (difference: 4%; 95% CI: -0.6%, 8.4%). Interobserver agreement was
      substantial for intraarterial DSA (kappa = 0.73; 95% CI: 0.64, 0.82) and moderate
      for MR angiography (kappa = 0.53; 95% CI: 0.36, 0.70). CONCLUSION: The overall
      proportion of patients advised to undergo additional treatment is similar based
      on intraarterial DSA and MR angiographic findings, with only few individual
      discrepancies. MR angiography can therefore be used for therapeutic decision
      making in the follow-up of patients with coil-treated aneurysms. SUPPLEMENTAL
      MATERIAL:
      http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.12112608/-/DC1.
CI  - (c) RSNA, 2012.
FAU - Schaafsma, Joanna D
AU  - Schaafsma JD
AD  - Department of Neurology and Neurosurgery, Rudolf Magnus Institute of
      Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, PO Box
      85500, 3508 GA Utrecht, the Netherlands. j.d.schaafsma@umcutrecht.nl
FAU - Velthuis, Birgitta K
AU  - Velthuis BK
FAU - van den Berg, Rene
AU  - van den Berg R
FAU - Brouwer, Patrick A
AU  - Brouwer PA
FAU - Majoie, Charles B L M
AU  - Majoie CB
FAU - Barkhof, Frederik
AU  - Barkhof F
FAU - Eshghi, Omid
AU  - Eshghi O
FAU - de Kort, Gerard A P
AU  - de Kort GA
FAU - Lo, Rob T H
AU  - Lo RT
FAU - Sprengers, Marieke E S
AU  - Sprengers ME
FAU - van Rooij, Willem-Jan
AU  - van Rooij WJ
FAU - Bot, Joseph C
AU  - Bot JC
FAU - Rinkel, Gabriel J E
AU  - Rinkel GJ
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20120925
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Angiography, Digital Subtraction/*methods
MH  - Cerebral Angiography/*methods
MH  - Confidence Intervals
MH  - *Decision Making
MH  - Embolization, Therapeutic/*methods
MH  - Female
MH  - Humans
MH  - Imaging, Three-Dimensional
MH  - Intracranial Aneurysm/*diagnosis/*therapy
MH  - Magnetic Resonance Angiography/*methods
MH  - Male
MH  - Middle Aged
MH  - Treatment Outcome
EDAT- 2012/09/27 06:00
MHDA- 2013/02/12 06:00
CRDT- 2012/09/27 06:00
PHST- 2012/09/27 06:00 [entrez]
PHST- 2012/09/27 06:00 [pubmed]
PHST- 2013/02/12 06:00 [medline]
AID - radiol.12112608 [pii]
AID - 10.1148/radiol.12112608 [doi]
PST - ppublish
SO  - Radiology. 2012 Dec;265(3):858-63. doi: 10.1148/radiol.12112608. Epub 2012 Sep
      25.


PMID- 23012462
OWN - NLM
STAT- MEDLINE
DCOM- 20130103
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 265
IP  - 2
DP  - 2012 Nov
TI  - Progressive supranuclear palsy: in vivo SPECT imaging of presynaptic vesicular
      acetylcholine transporter with [123I]-iodobenzovesamicol.
PG  - 537-43
LID - 10.1148/radiol.12112650 [doi]
AB  - PURPOSE: To evaluate the integrity of brain cholinergic pathways in vivo in
      patients with progressive supranuclear palsy (PSP) by measuring the vesicular
      acetylcholine transporter expression at single photon emission computed
      tomography (SPECT) with [123I]-iodobenzovesamicol. MATERIALS AND METHODS: All
      participants provided informed written consent according to institutional human
      ethics committee guidelines. Ten patients with PSP and 12 healthy volunteers
      underwent dynamic [123I]-iodobenzovesamicol SPECT and magnetic resonance (MR)
      imaging. CT and MR images were used to register the dynamic SPECT image to the
      Montreal Neurologic Institute brain template, which includes the regions of
      interest of the striatum and the septo-hippocampal, innominato-cortical, and
      ponto-thalamic cholinergic pathways. For each region of interest, pharmacokinetic
      modeling of regional time activity curves was used to calculate
      [123I]-iodobenzovesamicol to vesicular acetylcholine transporter binding
      potential value, proportional to vesicular acetylcholine transporter expression. 
      RESULTS: When compared with control participants, patients with PSP had binding
      potential values that were unchanged in the striatum and septohippocampal
      pathway, significantly lower in the anterior cingulate cortex (P=.017) in the
      innominatocortical pathway, and significantly decreased in the thalamus (P=.014) 
      in the pontothalamic cholinergic pathway. In addition, binding potential values
      in the thalamus were positively correlated with those in the pedunculopontine
      nucleus (rho=0.81, P<.004) and binding potential values in both the thalamus
      (rho=-0.88, P<.001) and pedunculopontine nucleus (rho=-0.80, P<.010) were
      inversely correlated with disease duration. CONCLUSION: Cholinergic pathways were
      differentially affected in the PSP group, with a significant alteration of
      pontothalamic pathways that increased with disease progression at both cell body 
      and terminal levels, while the innominatocortical pathway was only mildly
      affected, and the septohippocampal pathway and the striatum were both preserved.
CI  - (c) RSNA, 2012
FAU - Mazere, Joachim
AU  - Mazere J
AD  - Universite de Bordeaux, INCIA, UMR 5287, Talence, France.
      joachim.mazere@chu-bordeaux.fr
FAU - Meissner, Wassilios G
AU  - Meissner WG
FAU - Mayo, Willy
AU  - Mayo W
FAU - Sibon, Igor
AU  - Sibon I
FAU - Lamare, Federic
AU  - Lamare F
FAU - Guilloteau, Denis
AU  - Guilloteau D
FAU - Tison, Francois
AU  - Tison F
FAU - Allard, Michele
AU  - Allard M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120925
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Piperidines)
RN  - 0 (Radiopharmaceuticals)
RN  - 0 (Tetrahydronaphthalenes)
RN  - 0 (Vesicular Acetylcholine Transport Proteins)
RN  - 128192-12-1 (5-iodobenzovesamicol)
SB  - IM
MH  - Aged
MH  - Brain/diagnostic imaging/*metabolism
MH  - Female
MH  - Humans
MH  - Male
MH  - Piperidines/*pharmacokinetics
MH  - Presynaptic Terminals/diagnostic imaging/*metabolism
MH  - Radiopharmaceuticals
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Supranuclear Palsy, Progressive/diagnostic imaging/*metabolism
MH  - Tetrahydronaphthalenes/*pharmacokinetics
MH  - Tissue Distribution
MH  - Tomography, Emission-Computed, Single-Photon/*methods
MH  - Vesicular Acetylcholine Transport Proteins/*metabolism
EDAT- 2012/09/27 06:00
MHDA- 2013/01/04 06:00
CRDT- 2012/09/27 06:00
PHST- 2012/09/27 06:00 [entrez]
PHST- 2012/09/27 06:00 [pubmed]
PHST- 2013/01/04 06:00 [medline]
AID - radiol.12112650 [pii]
AID - 10.1148/radiol.12112650 [doi]
PST - ppublish
SO  - Radiology. 2012 Nov;265(2):537-43. doi: 10.1148/radiol.12112650. Epub 2012 Sep
      25.


PMID- 23012461
OWN - NLM
STAT- MEDLINE
DCOM- 20130103
LR  - 20130815
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 265
IP  - 2
DP  - 2012 Nov
TI  - Differentiation of early from advanced coronary atherosclerotic lesions:
      systematic comparison of CT, intravascular US, and optical frequency domain
      imaging with histopathologic examination in ex vivo human hearts.
PG  - 393-401
LID - 10.1148/radiol.12111891 [doi]
AB  - PURPOSE: To establish an ex vivo experimental setup for imaging coronary
      atherosclerosis with coronary computed tomographic (CT) angiography,
      intravascular ultrasonography (US), and optical frequency domain imaging (OFDI)
      and to investigate their ability to help differentiate early from advanced
      coronary plaques. MATERIALS AND METHODS: All procedures were performed in
      accordance with local and federal regulations and the Declaration of Helsinki.
      Approval of the local Ethics Committee was obtained. Overall, 379 histologic cuts
      from nine coronary arteries from three donor hearts were acquired, coregistered
      among modalities, and assessed for the presence and composition of
      atherosclerotic plaque. To assess the discriminatory capacity of the different
      modalities in the detection of advanced lesions, c statistic analysis was used.
      Interobserver agreement was assessed with the Cohen kappa statistic. RESULTS:
      Cross sections without plaque at coronary CT angiography and with fibrous plaque 
      at OFDI almost never showed advanced lesions at histopathologic examination (odds
      ratio [OR]: 0.02 and 0.06, respectively; both P<.0001), while mixed plaque at
      coronary CT angiography, calcified plaque at intravascular US, and lipid-rich
      plaque at OFDI were associated with advanced lesions (OR: 2.49, P=.0003; OR:
      2.60, P=.002; and OR: 31.2, P<.0001, respectively). OFDI had higher accuracy for 
      discriminating early from advanced lesions than intravascular US and coronary CT 
      angiography (area under the receiver operating characteristic curve: 0.858 [95%
      confidence interval {CI}: 0.802, 0.913], 0.631 [95% CI: 0.554, 0.709], and 0.679 
      [95% CI: 0.618, 0.740]; respectively, P<.0001). Interobserver agreement was
      excellent for OFDI and coronary CT angiography (kappa=0.87 and 0.85,
      respectively) and was good for intravascular US (kappa=0.66). CONCLUSION:
      Systematic and standardized comparison between invasive and noninvasive
      modalities for coronary plaque characterization in ex vivo specimens demonstrated
      that coronary CT angiography and intravascular US are reasonably associated with 
      plaque composition and lesion grading according to histopathologic findings,
      while OFDI was strongly associated. These data may help to develop initial
      concepts of sequential imaging strategies to identify patients with advanced
      coronary plaques.
CI  - (c) RSNA, 2012
FAU - Maurovich-Horvat, Pal
AU  - Maurovich-Horvat P
AD  - Cardiac MR PET CT Program of the Department of Radiology, Cardiology Division,
      and Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard 
      Medical School, 165 Cambridge St, Suite 400, Boston, MA 02114, USA.
FAU - Schlett, Christopher L
AU  - Schlett CL
FAU - Alkadhi, Hatem
AU  - Alkadhi H
FAU - Nakano, Masataka
AU  - Nakano M
FAU - Stolzmann, Paul
AU  - Stolzmann P
FAU - Vorpahl, Marc
AU  - Vorpahl M
FAU - Scheffel, Hans
AU  - Scheffel H
FAU - Tanaka, Atsushi
AU  - Tanaka A
FAU - Warger, William C 2nd
AU  - Warger WC 2nd
FAU - Maehara, Akiko
AU  - Maehara A
FAU - Ma, Shixin
AU  - Ma S
FAU - Kriegel, Matthias F
AU  - Kriegel MF
FAU - Kaple, Ryan K
AU  - Kaple RK
FAU - Seifarth, Harald
AU  - Seifarth H
FAU - Bamberg, Fabian
AU  - Bamberg F
FAU - Mintz, Gary S
AU  - Mintz GS
FAU - Tearney, Guillermo J
AU  - Tearney GJ
FAU - Virmani, Renu
AU  - Virmani R
FAU - Hoffmann, Udo
AU  - Hoffmann U
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120925
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
CIN - Radiology. 2013 Jul;268(1):304. PMID: 23793594
CIN - Radiology. 2013 Jul;268(1):304-5. PMID: 23951582
MH  - Cadaver
MH  - Coronary Angiography/*methods
MH  - Coronary Artery Disease/*diagnosis
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
MH  - Tomography, Optical Coherence/*methods
MH  - Tomography, X-Ray Computed/*methods
MH  - Ultrasonography, Interventional/*methods
EDAT- 2012/09/27 06:00
MHDA- 2013/01/04 06:00
CRDT- 2012/09/27 06:00
PHST- 2012/09/27 06:00 [entrez]
PHST- 2012/09/27 06:00 [pubmed]
PHST- 2013/01/04 06:00 [medline]
AID - radiol.12111891 [pii]
AID - 10.1148/radiol.12111891 [doi]
PST - ppublish
SO  - Radiology. 2012 Nov;265(2):393-401. doi: 10.1148/radiol.12111891. Epub 2012 Sep
      25.


PMID- 23011821
OWN - NLM
STAT- MEDLINE
DCOM- 20130503
LR  - 20151119
IS  - 1309-5730 (Electronic)
IS  - 1018-5615 (Linking)
VI  - 28
IP  - 3
DP  - 2012
TI  - The situation of consultation practice in pathology in Turkey.
PG  - 195-203
LID - 10.5146/tjpath.2012.01125 [doi]
AB  - OBJECTIVE: There are some suggestions regarding the methods of consultation
      practice in the literature including which case will be consulted, to whom, by
      which transport means, the payment methods as well as the ethical issues. There
      are no standards for consultations in Turkey. The standardization committee of
      the Federation of Turkish Pathology Societies has conducted a survey to detect
      the current situation, determine the problematic aspects, compare the situation
      with international methods and offer methods specific to Turkey. MATERIAL AND
      METHOD: A survey has been prepared to cover all the aspects of consultation
      practice using the literature and referring to the current methods used in
      Turkey. The survey has been announced on the internet and 83 replies were
      collected. RESULTS: Multiple choice questions were evaluated in terms of
      percentages and open ended questions were grouped according to the answer
      contents. It was seen that problems could be grouped as follows: absence of
      written procedures covering each step, means of transport, reaching the
      consultant, payment, reporting and ethical issues. The absence of procedures and 
      issues regarding the payment methods were the interfering factors for each step
      of consultation. CONCLUSION: There are many problematic issues in consultation
      practice in pathology in Turkey. The basis of these problems is the absence of
      written regulations for procedural and payment methods. Regulations addressing
      these issues should be developed.
FAU - Usubutun, Alp
AU  - Usubutun A
AD  - Department of Pathology, Hacettepe University, Faculty of Medicine, Ankara,
      Turkey. ausubutu@hacettepe.edu.tr
FAU - Balci, Serdar
AU  - Balci S
FAU - Yorukoglu, Kutsal
AU  - Yorukoglu K
LA  - eng
PT  - Journal Article
PL  - Turkey
TA  - Turk Patoloji Derg
JT  - Turk patoloji dergisi
JID - 9440471
SB  - IM
MH  - Humans
MH  - Pathology/*standards
MH  - Referral and Consultation/*standards
MH  - Surveys and Questionnaires
MH  - Turkey
EDAT- 2012/09/27 06:00
MHDA- 2013/05/04 06:00
CRDT- 2012/09/27 06:00
PHST- 2012/09/27 06:00 [entrez]
PHST- 2012/09/27 06:00 [pubmed]
PHST- 2013/05/04 06:00 [medline]
AID - 10.5146/tjpath.2012.01125 [doi]
PST - ppublish
SO  - Turk Patoloji Derg. 2012;28(3):195-203. doi: 10.5146/tjpath.2012.01125.


PMID- 23011625
OWN - NLM
STAT- MEDLINE
DCOM- 20130308
LR  - 20220408
IS  - 1550-9613 (Electronic)
IS  - 0278-4297 (Linking)
VI  - 31
IP  - 10
DP  - 2012 Oct
TI  - Prospective evaluation of Doppler sonography to detect the twinkling artifact
      versus unenhanced computed tomography for identifying urinary tract calculi.
PG  - 1619-25
AB  - OBJECTIVES: The twinkling artifact is an emerging tool for identifying urinary
      tract calculi. The purpose of this prospective study was to evaluate the
      diagnostic accuracy of the twinkling artifact compared to unenhanced computed
      tomography in detecting urolithasis. METHODS: After Research Ethics Board
      approval, 51 patients with flank pain from the emergency department were enrolled
      between November 2009 and September 2010. Patients received an unenhanced
      computed tomographic scan with 1.25-mm raw data and reformatted 5-mm axial and
      2-mm coronal images. Blinded assessment of the urinary tract was performed with
      gray-scale and color Doppler interrogation. The number of calculi, location,
      size, kidney distance from the skin, body mass index of the patient, and
      sonographic image parameters were recorded. RESULTS: There were 35 right-sided
      and 38 left-sided renal calculi, 14 right-sided and 21 left-sided ureteric
      calculi, and 6 bladder calculi (total, 114 calculi). Thirteen patients had no
      calculi. The average calculus size was 2.6 mm (range, 1-9 mm). There were 6
      false-positive and 22 false-negative instances of twinkling artifacts. On
      gray-scale evaluation looking for an echogenic focus with shadowing, there were 8
      false-positive and 40 false-negative findings. The positive predictive value
      (PPV) of the twinkling artifact for identifying calculi was 94%, and the
      sensitivity was 83%. The PPV of gray-scale sonographic shadowing was only 64.9%, 
      and the sensitivity was 80.2%. CONCLUSIONS: The twinkling artifact has a high PPV
      for detecting renal and urinary tract calculi. Evaluation for the twinkling
      artifact is a complementary technique to standard gray-scale shadowing of calculi
      and improves detection of urolithiasis on sonography.
FAU - Kielar, Ania Z
AU  - Kielar AZ
AD  - Department of Radiology, Ottawa Hospital, C-1, 1053 Carling Ave, Ottawa, ON K1R
      4E9, Canada. aniakielar@gmail.com
FAU - Shabana, Wael
AU  - Shabana W
FAU - Vakili, Maryam
AU  - Vakili M
FAU - Rubin, Jonathan
AU  - Rubin J
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PL  - England
TA  - J Ultrasound Med
JT  - Journal of ultrasound in medicine : official journal of the American Institute of
      Ultrasound in Medicine
JID - 8211547
RN  - 0 (Contrast Media)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Artifacts
MH  - Contrast Media
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Tomography, X-Ray Computed/*methods
MH  - Ultrasonography, Doppler/*methods
MH  - Urinary Calculi/*diagnosis
EDAT- 2012/09/27 06:00
MHDA- 2013/03/09 06:00
CRDT- 2012/09/27 06:00
PHST- 2012/09/27 06:00 [entrez]
PHST- 2012/09/27 06:00 [pubmed]
PHST- 2013/03/09 06:00 [medline]
AID - 31/10/1619 [pii]
AID - 10.7863/jum.2012.31.10.1619 [doi]
PST - ppublish
SO  - J Ultrasound Med. 2012 Oct;31(10):1619-25. doi: 10.7863/jum.2012.31.10.1619.


PMID- 23010439
OWN - NLM
STAT- MEDLINE
DCOM- 20130423
LR  - 20220409
IS  - 1096-0260 (Electronic)
IS  - 0091-7435 (Linking)
VI  - 55
IP  - 5
DP  - 2012 Nov
TI  - Overweight and reduced heart rate variability in British children: an exploratory
      study.
PG  - 430-2
LID - 10.1016/j.ypmed.2012.09.015 [doi]
LID - S0091-7435(12)00462-8 [pii]
AB  - OBJECTIVE: To investigate the associations between heart rate variability (HRV)
      and weight status in children. METHOD: Following ethics approval, 182 children
      (87 males, 95 females) aged between 6 and 11 years old (Mean (SD) age 9.1 (1.4)
      years) were assessed for height and body mass from which body mass index (BMI,
      kg/m(2)) was calculated. Data were collected in Central England, March-June 2011.
      Resting HRV was assessed in the supine position. Time domain (RMSSD and pNN50)
      and frequency domain (HF and LF power (ms(2)), LF/HF ratio) measures of HRV were 
      calculated. Pearson correlations were used to assess the associations between BMI
      and HRV parameters. Differences in HRV parameters according to gender or weight
      status were analysed using t-tests. RESULTS: BMI was significantly and inversely 
      related to RMSSD (r=-0.23, p=0.001) and pNN50 (r=0.20, p=0.008) but not frequency
      domain measures of HRV (p>0.05). Overweight/obese children demonstrated lower HF 
      power compared to normal weight children (p=0.02). RMSSD and pNN50 were
      significantly lower in overweight/obese children compared to normal weight
      children (p<0.05). Age was associated with changes in Mean R-R and RMSSD
      (p<0.05). CONCLUSION: This exploratory study suggests that HRV is reduced in
      overweight/obese children.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Birch, Samantha L
AU  - Birch SL
AD  - Department of Biomolecular and Sport Sciences, Coventry University, Coventry, UK.
      s.birch@coventry.ac.uk
FAU - Duncan, Michael J
AU  - Duncan MJ
FAU - Franklin, Craig
AU  - Franklin C
LA  - eng
PT  - Journal Article
DEP - 20120923
PL  - United States
TA  - Prev Med
JT  - Preventive medicine
JID - 0322116
SB  - IM
MH  - Autonomic Nervous System
MH  - Body Mass Index
MH  - Child
MH  - England
MH  - Female
MH  - *Heart Rate
MH  - Humans
MH  - Male
MH  - Obesity/physiopathology
MH  - Overweight/*physiopathology
EDAT- 2012/09/27 06:00
MHDA- 2013/04/24 06:00
CRDT- 2012/09/27 06:00
PHST- 2012/05/31 00:00 [received]
PHST- 2012/09/14 00:00 [revised]
PHST- 2012/09/15 00:00 [accepted]
PHST- 2012/09/27 06:00 [entrez]
PHST- 2012/09/27 06:00 [pubmed]
PHST- 2013/04/24 06:00 [medline]
AID - S0091-7435(12)00462-8 [pii]
AID - 10.1016/j.ypmed.2012.09.015 [doi]
PST - ppublish
SO  - Prev Med. 2012 Nov;55(5):430-2. doi: 10.1016/j.ypmed.2012.09.015. Epub 2012 Sep
      23.


PMID- 23009974
OWN - NLM
STAT- MEDLINE
DCOM- 20130311
LR  - 20220321
IS  - 1558-075X (Electronic)
IS  - 0146-0005 (Linking)
VI  - 36
IP  - 5
DP  - 2012 Oct
TI  - Fear of litigation and cesarean section rates.
PG  - 390-4
LID - 10.1053/j.semperi.2012.04.025 [doi]
LID - S0146-0005(12)00060-2 [pii]
AB  - Both the rates of cesarean section and the rates and payouts from obstetrical
      malpractice suits have risen in past decades, albeit not always in tandem. A
      great deal of evidence suggests that physicians practice defensive medicine, and 
      many obstetricians acknowledge that a more liberal recourse to cesarean section
      is one such behavior in which they sometimes engage. However the degree to which 
      fear of litigation actually is a contributor to, or perhaps even a driver of, the
      rising cesarean section rate is not as clearly known. In this article I will
      discuss the research that has been performed that attempts to epidemiologically
      assess the link between lawsuits, malpractice premiums and cesarean section
      rates. I will also consider factors beyond dollars and cents (e.g., cognitive
      biases, changing risk tolerance of doctors and patients) that may lie at the base
      of the relationship. Finally I will offer a brief discussion of how professional 
      ethics should inform the actions that physicians take in these difficult
      circumstances.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Minkoff, Howard
AU  - Minkoff H
AD  - Department of Obstetrics and Gynecology, Maimonides Medical Center, Brooklyn, NY 
      11219, USA. hminkoff@maimonidesmed.org
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Semin Perinatol
JT  - Seminars in perinatology
JID - 7801132
SB  - IM
MH  - Cesarean Section/*legislation & jurisprudence/statistics & numerical data
MH  - *Defensive Medicine
MH  - Female
MH  - Humans
MH  - Malpractice/*legislation & jurisprudence
MH  - Obstetrics/*legislation & jurisprudence
MH  - Physicians/legislation & jurisprudence
MH  - Pregnancy
MH  - Risk
EDAT- 2012/09/27 06:00
MHDA- 2013/03/12 06:00
CRDT- 2012/09/27 06:00
PHST- 2012/09/27 06:00 [entrez]
PHST- 2012/09/27 06:00 [pubmed]
PHST- 2013/03/12 06:00 [medline]
AID - S0146-0005(12)00060-2 [pii]
AID - 10.1053/j.semperi.2012.04.025 [doi]
PST - ppublish
SO  - Semin Perinatol. 2012 Oct;36(5):390-4. doi: 10.1053/j.semperi.2012.04.025.


PMID- 23009744
OWN - NLM
STAT- MEDLINE
DCOM- 20130128
LR  - 20211021
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 13
DP  - 2012 Sep 25
TI  - A qualitative study using traditional community assemblies to investigate
      community perspectives on informed consent and research participation in western 
      Kenya.
PG  - 23
LID - 10.1186/1472-6939-13-23 [doi]
AB  - BACKGROUND: International collaborators face challenges in the design and
      implementation of ethical biomedical research. Evaluating community understanding
      of research and processes like informed consent may enable researchers to better 
      protect research participants in a particular setting; however, there exist few
      studies examining community perspectives in health research, particularly in
      resource-limited settings, or strategies for engaging the community in research
      processes. Our goal was to inform ethical research practice in a biomedical
      research setting in western Kenya and similar resource-limited settings. METHODS:
      We sought to use mabaraza, traditional East African community assemblies, in a
      qualitative study to understand community perspectives on biomedical research and
      informed consent within a collaborative, multinational research network in
      western Kenya. Analyses included manual, progressive coding of transcripts from
      mabaraza to identify emerging central concepts. RESULTS: Our findings from two
      mabaraza with 108 community members revealed that, while participants understood 
      some principles of biomedical research, they emphasized perceived benefits from
      participation in research over potential risks. Many community members equated
      health research with HIV testing or care, which may be explained in part by the
      setting of this particular study. In addition to valuing informed consent as
      understanding and accepting a role in research activities, participants endorsed 
      an increased role for the community in making decisions about research
      participation, especially in the case of children, through a process of community
      consent. CONCLUSIONS: Our study suggests that international biomedical research
      must account for community understanding of research and informed consent,
      particularly when involving children. Moreover, traditional community forums,
      such as mabaraza in East Africa, can be used effectively to gather these data and
      may serve as a forum to further engage communities in community consent and other
      aspects of research.
FAU - Vreeman, Rachel
AU  - Vreeman R
AD  - Department of Pediatrics, Indiana University School of Medicine, 705 Riley
      Hospital Drive, Room 5900, Indianapolis, IN 46202, USA. rvreeman@iupui.edu
FAU - Kamaara, Eunice
AU  - Kamaara E
FAU - Kamanda, Allan
AU  - Kamanda A
FAU - Ayuku, David
AU  - Ayuku D
FAU - Nyandiko, Winstone
AU  - Nyandiko W
FAU - Atwoli, Lukoye
AU  - Atwoli L
FAU - Ayaya, Samuel
AU  - Ayaya S
FAU - Gisore, Peter
AU  - Gisore P
FAU - Scanlon, Michael
AU  - Scanlon M
FAU - Braitstein, Paula
AU  - Braitstein P
LA  - eng
GR  - R01 HD060478/HD/NICHD NIH HHS/United States
GR  - 1K23MH087225-01/MH/NIMH NIH HHS/United States
GR  - 1R01HD060478-01A1/HD/NICHD NIH HHS/United States
GR  - PEPFAR/PEPFAR/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20120925
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Biomedical Research/ethics
MH  - Clinical Trials as Topic/*ethics
MH  - *Comprehension
MH  - Ethics, Research
MH  - HIV Infections/diagnosis/therapy
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - *Informed Consent
MH  - Kenya
MH  - Patient Selection
MH  - Qualitative Research
MH  - Research Design
MH  - Research Subjects
MH  - *Residence Characteristics
MH  - Third-Party Consent
PMC - PMC3515354
EDAT- 2012/09/27 06:00
MHDA- 2013/01/29 06:00
CRDT- 2012/09/27 06:00
PHST- 2012/06/19 00:00 [received]
PHST- 2012/09/03 00:00 [accepted]
PHST- 2012/09/27 06:00 [entrez]
PHST- 2012/09/27 06:00 [pubmed]
PHST- 2013/01/29 06:00 [medline]
AID - 1472-6939-13-23 [pii]
AID - 10.1186/1472-6939-13-23 [doi]
PST - epublish
SO  - BMC Med Ethics. 2012 Sep 25;13:23. doi: 10.1186/1472-6939-13-23.


PMID- 23009718
OWN - NLM
STAT- MEDLINE
DCOM- 20140403
LR  - 20220311
IS  - 1365-2524 (Electronic)
IS  - 0966-0410 (Linking)
VI  - 21
IP  - 4
DP  - 2013 Jul
TI  - Why do patients with long-term conditions use unscheduled care? A qualitative
      literature review.
PG  - 339-51
LID - 10.1111/j.1365-2524.2012.01093.x [doi]
AB  - Unscheduled care (UC) refers to non-routine face-to-face care, such as accident
      and emergency care, out-of-hours care, or walk-in centres. Current health service
      policy aims to reduce its use. Unscheduled care is common in people with
      long-term conditions such as diabetes, asthma, chronic obstructive pulmonary
      disease and coronary heart disease. By reviewing qualitative research literature,
      we aimed to understand the breadth of psychosocial and other influences on UC use
      in people with long-term conditions. Few qualitative papers specifically address 
      UC in patients in these disease groups. Therefore, our literature search also
      included qualitative research that explored factors potentially relevant to UC
      use, including attitudes to healthcare use in general. By searching Medline,
      Embase, Psycinfo and Cinahl from inception to 2011, we identified 42 papers,
      published since 1984, describing relevant original research and took a
      meta-ethnographic approach in reviewing them. The review was conducted between
      Spring 2009 and April 2011, with a further search in December 2011. Most papers
      reported on asthma (n = 13) or on multiple or unspecified conditions (n = 12).
      The most common methods reported were interviews (n = 33) and focus groups (n =
      13), and analyses were generally descriptive. Theoretical and ethical background 
      was rarely explicit, but the implicit starting point was generally the 'problem' 
      of UC, and health-care, use in general, decontextualised from the lives of the
      patients using it. Patients' use of UC emerged as understandable, rational
      responses to pressing clinical need in situations in which patients thought it
      the only option. This belief reflected the value that they had learned to attach 
      to UC versus routine care through previous experiences. For socially or
      economically marginalised patients, UC offered access to clinical or social care 
      that was otherwise unavailable to them.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Langer, Susanne
AU  - Langer S
AD  - Mental and Behavioural Health Sciences, Institute of Psychology, Health and
      Society, University of Liverpool, UK. s.langer@liv.ac.uk
FAU - Chew-Graham, Carolyn
AU  - Chew-Graham C
FAU - Hunter, Cheryl
AU  - Hunter C
FAU - Guthrie, Elspeth A
AU  - Guthrie EA
FAU - Salmon, Peter
AU  - Salmon P
LA  - eng
GR  - RP-PG-0707-10162/DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120925
PL  - England
TA  - Health Soc Care Community
JT  - Health & social care in the community
JID - 9306359
SB  - IM
MH  - *Chronic Disease/psychology
MH  - Emergency Medical Services/*statistics & numerical data
MH  - *Health Services Misuse
MH  - Humans
MH  - United Kingdom
PMC - PMC3796281
MID - EMS54065
OID - NLM: EMS54065
EDAT- 2012/09/27 06:00
MHDA- 2014/04/04 06:00
CRDT- 2012/09/27 06:00
PHST- 2012/09/27 06:00 [entrez]
PHST- 2012/09/27 06:00 [pubmed]
PHST- 2014/04/04 06:00 [medline]
AID - 10.1111/j.1365-2524.2012.01093.x [doi]
PST - ppublish
SO  - Health Soc Care Community. 2013 Jul;21(4):339-51. doi:
      10.1111/j.1365-2524.2012.01093.x. Epub 2012 Sep 25.


PMID- 23009715
OWN - NLM
STAT- MEDLINE
DCOM- 20130621
LR  - 20211021
IS  - 1756-0500 (Electronic)
IS  - 1756-0500 (Linking)
VI  - 5
DP  - 2012 Sep 25
TI  - Perinatal characteristics among early (10-14 years old) and late (15-19 years
      old) pregnant adolescents.
PG  - 531
LID - 10.1186/1756-0500-5-531 [doi]
AB  - BACKGROUND: Pregnancy in adolescents is a worldwide health problem and has been
      mostly common in poor populations. It is not clear if socioeconomic or biological
      factors are the main determinants of perinatal adverse outcomes in pregnant
      adolescents. Adolescents under 15 years old may present a high growth rate which 
      may contribute to impair fetal growth. Our aim is to compare perinatal
      characteristics among early (aged 10 to 14 years) and late (aged 15 to 19 years) 
      pregnant adolescents. METHODS: A cross-sectional study was performed using data
      from Pernambuco State 2009, obtained from DATASUS/SISNAC, a Brazilian Government,
      open-access public health database. Maternal and neonatal outcomes were compared 
      between early (aged 10-14 years) and late (aged 15-19 years) pregnant
      adolescents. Family income was compared between early and late pregnant
      adolescents using a sample of 412 subjects evaluated at Instituto de Medicina
      Integral Prof. Fernando Figueira (IMIP) during 2011. Statistical comparisons were
      made using the chi-square test was used with a significant level of 0.05;
      bivariate and multivariate analysis were performed. This project was approved by 
      the Institutional Ethics Review Board. RESULTS: Data from 31,209 pregnant
      adolescents were analyzed. 29,733 (95.2%) were aged 15 to 19 years and 1,476
      (4.7%) were aged 10 to 14 years. There were significant differences with respect 
      to marital status, education level and number of prenatal visits of mothers aged 
      10 to 14 years compared to 15 to 19 years. Of importance, early adolescents had a
      greater rate of neonates born premature and with low birth weight. Prematurity
      and low birth weight remained statistically significant after multivariate
      analysis. CONCLUSIONS: Early aged adolescents may have an increased risk of
      prematurity and low birth weight. These findings highlight the potential role of 
      biological factors in newborn outcomes in pregnant adolescents.
FAU - Alves, Joao Guilherme Bezerra
AU  - Alves JG
AD  - Instituto de Medicina Integral Prof, Fernando Figueira (IMIP), Rua dos Coelhos
      300, Boa Vista, Recife PE, ZIP: 50070-550, Brazil. joaoguilherme@imip.org.br
FAU - Cisneiros, Rosangela Meira Rodrigues
AU  - Cisneiros RM
FAU - Dutra, Luciana Paula Fernandes
AU  - Dutra LP
FAU - Pinto, Renato Americo
AU  - Pinto RA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120925
PL  - England
TA  - BMC Res Notes
JT  - BMC research notes
JID - 101462768
SB  - IM
MH  - Adolescent
MH  - Brazil
MH  - Child
MH  - Cross-Sectional Studies
MH  - Databases, Factual
MH  - Educational Status
MH  - Female
MH  - Humans
MH  - Income
MH  - *Infant, Low Birth Weight
MH  - Infant, Newborn
MH  - *Infant, Premature
MH  - Male
MH  - Multivariate Analysis
MH  - Perinatal Care
MH  - Pregnancy
MH  - Pregnancy Complications/physiopathology
MH  - Pregnancy in Adolescence/*statistics & numerical data
MH  - Risk
MH  - Young Adult
PMC - PMC3582532
EDAT- 2012/09/27 06:00
MHDA- 2013/06/26 06:00
CRDT- 2012/09/27 06:00
PHST- 2012/07/12 00:00 [received]
PHST- 2012/09/24 00:00 [accepted]
PHST- 2012/09/27 06:00 [entrez]
PHST- 2012/09/27 06:00 [pubmed]
PHST- 2013/06/26 06:00 [medline]
AID - 1756-0500-5-531 [pii]
AID - 10.1186/1756-0500-5-531 [doi]
PST - epublish
SO  - BMC Res Notes. 2012 Sep 25;5:531. doi: 10.1186/1756-0500-5-531.


PMID- 23009665
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121022
LR  - 20211021
IS  - 1478-4491 (Electronic)
IS  - 1478-4491 (Linking)
VI  - 10
DP  - 2012 Sep 25
TI  - Effect of UK policy on medical migration: a time series analysis of physician
      registration data.
PG  - 35
LID - 10.1186/1478-4491-10-35 [doi]
AB  - BACKGROUND: Economically developed countries have recruited large numbers of
      overseas health workers to fill domestic shortages. Recognition of the negative
      impact this can have on health care in developing countries led the United
      Kingdom Department of Health to issue a Code of Practice for National Health
      Service (NHS) employers in 1999 providing ethical guidance on international
      recruitment. Case reports suggest this guidance had limited influence in the
      context of other NHS policy priorities. METHODS: The temporal association between
      trends in new professional registrations from doctors qualifying overseas and
      relevant United Kingdom government policy is reported. Government policy
      documents were identified by a literature review; further information was
      obtained, when appropriate, through requests made under the Freedom of
      Information Act. Data on new professional registration of doctors were obtained
      from the General Medical Council (GMC). RESULTS: New United Kingdom professional 
      registrations by doctors trained in Africa and south Asia more than doubled from 
      3105 in 2001 to 7343 in 2003, as NHS Trusts sought to achieve recruitment targets
      specified in the 2000 NHS Plan; this occurred despite ethical guidance to avoid
      active recruitment of doctors from resource-poor countries. Registration of such 
      doctors declined subsequently, but in response to other government policy
      initiatives. A fall in registration of South African-trained doctors from 3206 in
      2003 to 4 in 2004 followed a Memorandum of Understanding with South Africa signed
      in 2003. Registrations from India and Pakistan fell from a peak of 4626 in 2004
      to 1169 in 2007 following changes in United Kingdom immigration law in 2005 and
      2006. Since 2007, registration of new doctors trained outside the European
      Economic Area has remained relatively stable, but in 2010 the United Kingdom
      still registered 722 new doctors trained in Africa and 1207 trained in India and 
      Pakistan. CONCLUSIONS: Ethical guidance was ineffective in preventing mass
      registration by doctors trained in resource-poor countries between 2001 and 2004 
      because of competing NHS policy priorities. Changes in United Kingdom immigration
      laws and bilateral agreements have subsequently reduced new registrations, but
      about 4000 new doctors a year continue to register who trained in Africa, Asia
      and less economically developed European countries.
FAU - Blacklock, Claire
AU  - Blacklock C
AD  - Department of Primary Care Health Sciences, Oxford University, Radcliffe
      Observatory Quarter, Oxford , OX2 6GG, UK. claire.blacklock@phc.ox.ac.uk.
FAU - Heneghan, Carl
AU  - Heneghan C
FAU - Mant, David
AU  - Mant D
FAU - Ward, Alison M
AU  - Ward AM
LA  - eng
PT  - Journal Article
DEP - 20120925
PL  - England
TA  - Hum Resour Health
JT  - Human resources for health
JID - 101170535
PMC - PMC3476980
EDAT- 2012/09/27 06:00
MHDA- 2012/09/27 06:01
CRDT- 2012/09/27 06:00
PHST- 2011/07/20 00:00 [received]
PHST- 2012/06/13 00:00 [accepted]
PHST- 2012/09/27 06:00 [entrez]
PHST- 2012/09/27 06:00 [pubmed]
PHST- 2012/09/27 06:01 [medline]
AID - 1478-4491-10-35 [pii]
AID - 10.1186/1478-4491-10-35 [doi]
PST - epublish
SO  - Hum Resour Health. 2012 Sep 25;10:35. doi: 10.1186/1478-4491-10-35.


PMID- 23009594
OWN - NLM
STAT- MEDLINE
DCOM- 20140303
LR  - 20191210
IS  - 1447-0349 (Electronic)
IS  - 1445-8330 (Linking)
VI  - 22
IP  - 4
DP  - 2013 Aug
TI  - Police referrals to a psychiatric hospital: experiences of nurses caring for
      police-referred admissions.
PG  - 313-21
LID - 10.1111/j.1447-0349.2012.00881.x [doi]
AB  - Police are a major source of referral to psychiatric hospitals in industrialized 
      countries with mental health legislation. However, little attention has been paid
      to nurses' experience of caring for police-referred patients to psychiatric
      hospitals. This study utilized a Heideggerian phenomenological framework to
      explore the experiences of nine nurses caring for patients referred by the
      police, through semistructured interviews. Two major themes emerged from the
      hermeneutic analyses of interviews conducted with nurse participants: (i)
      'expecting "the worst" '; and (ii) 'balancing therapeutic care and forced
      treatment'. Expecting 'the worst' related to the perceptions nurse participants
      had about patients referred by the police. This included two sub-themes: (i) 'we 
      are here to care for whoever they bring in'; and (ii) 'but who deserves care?'
      The second theme balancing therapeutic care and forced treatment included the
      sub-themes: (i) 'taking control, taking care'; and (ii) 'managing power'. The
      study raises ethical and skill challenges for nursing including struggling with
      the notion of who deserves care, and balancing the imperatives of legislation
      with the need to work within a therapeutic framework.
CI  - (c) 2012 The Authors; International Journal of Mental Health Nursing (c) 2012
      Australian College of Mental Health Nurses Inc.
FAU - Maharaj, Reshin
AU  - Maharaj R
AD  - Western Sydney Local Health District, Sydney, Australia.
      reshin.maharaj@swahs.health.nsw.gov.au
FAU - O'Brien, Louise
AU  - O'Brien L
FAU - Gillies, Donna
AU  - Gillies D
FAU - Andrew, Sharon
AU  - Andrew S
LA  - eng
PT  - Journal Article
DEP - 20120925
PL  - Australia
TA  - Int J Ment Health Nurs
JT  - International journal of mental health nursing
JID - 101140527
MH  - Adult
MH  - Aggression/psychology
MH  - Alcoholism/nursing/psychology
MH  - *Attitude of Health Personnel
MH  - *Commitment of Mentally Ill/legislation & jurisprudence
MH  - Comorbidity
MH  - Crisis Intervention
MH  - Female
MH  - *Hospitals, Psychiatric/legislation & jurisprudence
MH  - Humans
MH  - Internal-External Control
MH  - Interview, Psychological
MH  - Male
MH  - Middle Aged
MH  - New South Wales
MH  - *Nurse-Patient Relations
MH  - *Police
MH  - Power, Psychological
MH  - Psychoses, Substance-Induced/nursing/psychology
MH  - *Referral and Consultation
MH  - Substance-Related Disorders/nursing/psychology
EDAT- 2012/09/27 06:00
MHDA- 2014/03/04 06:00
CRDT- 2012/09/27 06:00
PHST- 2012/09/27 06:00 [entrez]
PHST- 2012/09/27 06:00 [pubmed]
PHST- 2014/03/04 06:00 [medline]
AID - 10.1111/j.1447-0349.2012.00881.x [doi]
PST - ppublish
SO  - Int J Ment Health Nurs. 2013 Aug;22(4):313-21. doi:
      10.1111/j.1447-0349.2012.00881.x. Epub 2012 Sep 25.


PMID- 23009560
OWN - NLM
STAT- MEDLINE
DCOM- 20160218
LR  - 20161125
IS  - 1467-9566 (Electronic)
IS  - 0141-9889 (Linking)
VI  - 35
IP  - 3
DP  - 2013 Mar
TI  - Body work in assisted conception: exploring public and private settings.
PG  - 465-78
LID - 10.1111/j.1467-9566.2012.01502.x [doi]
AB  - Body work has been foregrounded in recent sociological writings on health and
      social care, particularly the emotional labour of patient care. In this article I
      explore the social and emotional dimensions of body work in assisted conception
      in private and public National Health Service (NHS) clinics. Drawing on an
      ethnographic study, I explore how tensions around bodily attributes, treatment
      costs, clinic performance and the extent of consumer sovereignty were managed in 
      decisions about who to treat and in what manner. In NHS settings, body work
      involved efforts to standardise and constrain bodies in line with an ethics of
      justice that included the co-construction of protocols and performance
      measurement and a strong emphasis upon teamwork and influencing the behaviour of 
      the sector as a whole. In contrast, body work in private settings was more
      overtly organised around an ethos of individual consumption that emphasised
      bespoke treatment together with an active critique of the regulator, based on a
      strong entrepreneurial ethos. Emotional labour in private settings was also more 
      overt. I conclude by exploring the implications of my analysis for the study of
      assisted conception, the sociology of body work and the further marketisation and
      deregulation of medicine.
CI  - (c) 2012 The Authors. Sociology of Health & Illness (c) 2012 Foundation for the
      Sociology of Health & Illness/Blackwell Publishing Ltd.
FAU - Kerr, Anne
AU  - Kerr A
AD  - School of Sociology and Social Policy, University of Leeds.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120926
PL  - England
TA  - Sociol Health Illn
JT  - Sociology of health & illness
JID - 8205036
SB  - IM
MH  - Anthropology, Cultural
MH  - Emotions
MH  - Humans
MH  - Life Style
MH  - Physician's Role
MH  - Private Sector/economics/*organization & administration
MH  - Quality of Health Care
MH  - Reproductive Techniques, Assisted/*psychology
MH  - State Medicine/economics/*organization & administration
MH  - Time Factors
MH  - United Kingdom
OTO - NOTNLM
OT  - assisted conception
OT  - body work
OT  - ethics
OT  - marketisation
OT  - practice
EDAT- 2012/09/27 06:00
MHDA- 2016/02/19 06:00
CRDT- 2012/09/27 06:00
PHST- 2012/09/27 06:00 [entrez]
PHST- 2012/09/27 06:00 [pubmed]
PHST- 2016/02/19 06:00 [medline]
AID - 10.1111/j.1467-9566.2012.01502.x [doi]
PST - ppublish
SO  - Sociol Health Illn. 2013 Mar;35(3):465-78. doi: 10.1111/j.1467-9566.2012.01502.x.
      Epub 2012 Sep 26.


PMID- 23009268
OWN - NLM
STAT- MEDLINE
DCOM- 20130301
LR  - 20191210
IS  - 1545-5815 (Electronic)
IS  - 0898-9621 (Linking)
VI  - 19
IP  - 5
DP  - 2012
TI  - Risk assessment as a paradox: when actions of an IRB become incompatible with
      ethical principles.
PG  - 273-84
AB  - As anecdotal evidence mounts up of Institutional Review Boards becoming an
      impediment to research, I share a personal experience in this article to argue
      how the conduct of an Institutional Review Board was incompatible with a number
      of ethical principles such as Respect for Persons, Deception, Informed Consent,
      and Justice. I conclude by promoting Evidence-Based Ethical Problem Solving to
      facilitate and enhance risk assessments through empirical evidence.
FAU - Ranjbar, Vania
AU  - Ranjbar V
AD  - Department of Psychology, The University of Edinburgh, Edinburgh, Scotland, UK.
      v.ranjbar@sms.ed.ac.uk
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Account Res
JT  - Accountability in research
JID - 9100813
SB  - IM
MH  - *Conflict, Psychological
MH  - Ethics Committees, Research/*ethics
MH  - *Ethics, Research
MH  - Humans
MH  - Informed Consent/ethics
MH  - Problem Solving/ethics
MH  - Risk Assessment/*methods
MH  - Social Justice
MH  - United States
EDAT- 2012/09/27 06:00
MHDA- 2013/03/02 06:00
CRDT- 2012/09/27 06:00
PHST- 2012/09/27 06:00 [entrez]
PHST- 2012/09/27 06:00 [pubmed]
PHST- 2013/03/02 06:00 [medline]
AID - 10.1080/08989621.2012.718678 [doi]
PST - ppublish
SO  - Account Res. 2012;19(5):273-84. doi: 10.1080/08989621.2012.718678.


PMID- 23009102
OWN - NLM
STAT- MEDLINE
DCOM- 20130401
LR  - 20211021
IS  - 1471-2431 (Electronic)
IS  - 1471-2431 (Linking)
VI  - 12
DP  - 2012 Sep 25
TI  - Assessing children's competence to consent in research by a standardized tool: a 
      validity study.
PG  - 156
LID - 10.1186/1471-2431-12-156 [doi]
AB  - BACKGROUND: Currently over 50% of drugs prescribed to children have not been
      evaluated properly for use in their age group. One key reason why children have
      been excluded from clinical trials is that they are not considered able to
      exercise meaningful autonomy over the decision to participate. Dutch law states
      that competence to consent can be presumed present at the age of 12 and above;
      however, in pediatric practice children's competence is not that clearly
      presented and the transition from assent to active consent is gradual. A gold
      standard for competence assessment in children does not exist. In this article we
      describe a study protocol on the development of a standardized tool for assessing
      competence to consent in research in children and adolescents. METHODS/DESIGN: In
      this study we modified the MacCAT-CR, the best evaluated competence assessment
      tool for adults, for use in children and adolescents. We will administer the tool
      prospectively to a cohort of pediatric patients from 6 to18 years during the
      selection stages of ongoing clinical trials. The outcomes of the MacCAT-CR
      interviews will be compared to a reference standard, established by the judgments
      of clinical investigators, and an expert panel consisting of child psychiatrists,
      child psychologists and medical ethicists. The reliability, criterion-related
      validity and reproducibility of the tool will be determined. As MacCAT-CR is a
      multi-item scale consisting of 13 items, power was justified at 130-190 subjects,
      providing a minimum of 10-15 observations per item. MacCAT-CR outcomes will be
      correlated with age, life experience, IQ, ethnicity, socio-economic status and
      competence judgment of the parent(s). It is anticipated that 160 participants
      will be recruited over 2 years to complete enrollment. DISCUSSION: A validity
      study on an assessment tool of competence to consent is strongly needed in
      research practice, particularly in the child and adolescent population. In this
      study we will establish a reference standard of children's competence to consent,
      combined with validation of an assessment instrument. Results can facilitate
      responsible involvement of children in clinical trials by further development of 
      guidelines, health-care policies and legal policies.
FAU - Hein, Irma M
AU  - Hein IM
AD  - Department of Child and Adolescent Psychiatry and de Bascule, Academic Medical
      Center Amsterdam, Meibergdreef 5, Amsterdam, 1105, AZ, The Netherlands.
      i.hein@debascule.com
FAU - Troost, Pieter W
AU  - Troost PW
FAU - Lindeboom, Robert
AU  - Lindeboom R
FAU - de Vries, Martine C
AU  - de Vries MC
FAU - Zwaan, C Michel
AU  - Zwaan CM
FAU - Lindauer, Ramon J L
AU  - Lindauer RJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120925
PL  - England
TA  - BMC Pediatr
JT  - BMC pediatrics
JID - 100967804
SB  - IM
MH  - Adolescent
MH  - *Biomedical Research
MH  - Child
MH  - Humans
MH  - *Informed Consent
MH  - Mental Competency
MH  - Prospective Studies
MH  - Reproducibility of Results
MH  - *Surveys and Questionnaires
PMC - PMC3506483
EDAT- 2012/09/27 06:00
MHDA- 2013/04/02 06:00
CRDT- 2012/09/27 06:00
PHST- 2012/09/12 00:00 [received]
PHST- 2012/09/21 00:00 [accepted]
PHST- 2012/09/27 06:00 [entrez]
PHST- 2012/09/27 06:00 [pubmed]
PHST- 2013/04/02 06:00 [medline]
AID - 1471-2431-12-156 [pii]
AID - 10.1186/1471-2431-12-156 [doi]
PST - epublish
SO  - BMC Pediatr. 2012 Sep 25;12:156. doi: 10.1186/1471-2431-12-156.


PMID- 23009068
OWN - NLM
STAT- MEDLINE
DCOM- 20130530
LR  - 20211203
IS  - 1756-0500 (Electronic)
IS  - 1756-0500 (Linking)
VI  - 5
DP  - 2012 Sep 26
TI  - Coeliac disease and C virus-related chronic hepatitis: a non association.
PG  - 533
LID - 10.1186/1756-0500-5-533 [doi]
AB  - BACKGROUND: A higher prevalence of coeliac disease has recently been reported
      among patients with HCV-related chronic hepatitis. Moreover, development of
      clinically overt coeliac disease has been described in a number of HCV-related
      chronic hepatitis patients during alpha-interferon therapy. This prospective
      study was designed to evaluate 1) the prevalence of coeliac disease in patients
      with HCV-related chronic hepatitis; 2) the prevalence of HCV infection in
      patients with coeliac disease; 3) whether PEG interferon-alpha treatment might
      favour the development of coeliac disease in patients with chronic hepatitis C.
      MATERIALS AND METHODS: Two hundred-ten consecutive patients (M/F = 140/70, range 
      of age 35-58 years, median age 46.5 years) with biopsy proven chronic hepatitis C
      underwent serological screening for antiendomysial and tissue transglutaminase
      IgA antibodies. One hundred ninety-four coeliac patients (M/F = 52/142, range of 
      age 18-74 years, median age 34 years) were screened for HCV antibodies.
      Positivity for HCV antibodies in coeliac disease patients was confirmed by
      detection of serum HCV-RNA by RT-PCR. This work was carried out in accordance to 
      ethical guidelines of Declaration of Helsinki and was approved by Institutional
      Ethics Committee of the Second University of Naples. All patients gave informed
      written consent. RESULTS: 1) none of the 210 HCV-related chronic hepatitis
      patients were positive for coeliac disease serologic screening; 2) prevalence of 
      HCV infection among coeliac patients was 1.54% (3/194) which is comparable to
      that reported in the Southern Italy population; 3) PEG interferon-alpha treatment
      was not associated with development of coeliac disease either clinical or
      serological. CONCLUSIONS: 1) coeliac disease is not associated with HCV
      infection; 2) PEG interferon-alpha does not trigger celiac disease.
FAU - Gravina, Antonietta Gerarda
AU  - Gravina AG
AD  - Department of Clinical and Experimental Medicine and Surgery F Magrassi e A
      Lanzara - Hepato-Gastroenterology Division and C.I.R.A.N.A.D., Second University 
      of Naples, via Pansini 5, Naples 80131, Italy. antonietta.gravina@yahoo.it
FAU - Federico, Alessandro
AU  - Federico A
FAU - Masarone, Mario
AU  - Masarone M
FAU - Cuomo, Antonio
AU  - Cuomo A
FAU - Tuccillo, Concetta
AU  - Tuccillo C
FAU - Loguercio, Carmelina
AU  - Loguercio C
FAU - Persico, Marcello
AU  - Persico M
FAU - Romano, Marco
AU  - Romano M
LA  - eng
PT  - Journal Article
DEP - 20120926
PL  - England
TA  - BMC Res Notes
JT  - BMC research notes
JID - 101462768
RN  - 0 (Antiviral Agents)
RN  - 0 (Autoantibodies)
RN  - 0 (Hepatitis C Antibodies)
RN  - 0 (Interferon-alpha)
RN  - 0 (RNA, Viral)
RN  - EC 2.3.2.13 (Protein Glutamine gamma Glutamyltransferase 2)
RN  - EC 2.3.2.13 (Transglutaminases)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
SB  - IM
MH  - Adult
MH  - Antiviral Agents/adverse effects
MH  - Autoantibodies/blood
MH  - Celiac Disease/blood/diagnosis/*epidemiology/immunology
MH  - Female
MH  - GTP-Binding Proteins
MH  - Hepacivirus/genetics/immunology
MH  - Hepatitis C Antibodies/blood
MH  - Hepatitis C, Chronic/blood/diagnosis/drug therapy/*epidemiology
MH  - Humans
MH  - Interferon-alpha/adverse effects
MH  - Italy/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Prevalence
MH  - Prospective Studies
MH  - Protein Glutamine gamma Glutamyltransferase 2
MH  - RNA, Viral/blood
MH  - Risk Factors
MH  - Transglutaminases/immunology
MH  - Viral Load
PMC - PMC3544570
EDAT- 2012/09/27 06:00
MHDA- 2013/06/01 06:00
CRDT- 2012/09/27 06:00
PHST- 2012/04/18 00:00 [received]
PHST- 2012/09/22 00:00 [accepted]
PHST- 2012/09/27 06:00 [entrez]
PHST- 2012/09/27 06:00 [pubmed]
PHST- 2013/06/01 06:00 [medline]
AID - 1756-0500-5-533 [pii]
AID - 10.1186/1756-0500-5-533 [doi]
PST - epublish
SO  - BMC Res Notes. 2012 Sep 26;5:533. doi: 10.1186/1756-0500-5-533.


PMID- 23008965
OWN - NLM
STAT- MEDLINE
DCOM- 20130103
LR  - 20181201
IS  - 0039-4521 (Print)
IS  - 0039-4521 (Linking)
VI  - 55
IP  - 4
DP  - 2012 Jul-Aug
TI  - [Inter-regional scientific and practical conference "Topical problems of forensic
      medicine, medical law, and biomedical ethics"].
PG  - 68-9
FAU - Barinov, E Kh
AU  - Barinov EKh
FAU - Erofeev, S V
AU  - Erofeev SV
FAU - Semenov, A V
AU  - Semenov AV
FAU - Romodanovskii, P O
AU  - Romodanovskii PO
LA  - rus
PT  - Congress
PL  - Russia (Federation)
TA  - Sud Med Ekspert
JT  - Sudebno-meditsinskaia ekspertiza
JID - 0404546
SB  - IM
MH  - *Ethics, Medical
MH  - Forensic Medicine/ethics/legislation & jurisprudence/*methods
MH  - *Legislation, Medical
MH  - Russia
EDAT- 2012/09/27 06:00
MHDA- 2013/01/04 06:00
CRDT- 2012/09/27 06:00
PHST- 2012/09/27 06:00 [entrez]
PHST- 2012/09/27 06:00 [pubmed]
PHST- 2013/01/04 06:00 [medline]
PST - ppublish
SO  - Sud Med Ekspert. 2012 Jul-Aug;55(4):68-9.


PMID- 23008925
OWN - NLM
STAT- MEDLINE
DCOM- 20121016
LR  - 20120926
IS  - 0377-9343 (Print)
IS  - 0377-9343 (Linking)
VI  - 54
IP  - 3
DP  - 2012 Jul-Sep
TI  - Research in clinical sciences.
PG  - 175-82
AB  - The scope and spectrum of medical research, including that in clinical sciences
      has tremendously expanded. It now extends from simple clinical observations to
      gathering of epidemiological data to the study of molecular mechanisms of
      diseases to evaluation of effects of therapeutic interventions. It is more
      meaningful to engage in multi-disciplinary and collaborative arrangements for the
      better achievements in health research. Translational approach involves the
      direct application of results of laboratory experiments to clinical use for
      benefit of patients. Besides clinical and experimental research, it is equally
      important to strengthen operational research for efficient implementation of
      health programmes and policies in the hospitals as well as in the community.
      There are several difficulties and constraints related to ethical principles,
      patient's safety, confidentiality and costs. It is critically important to adhere
      to ethical principles and guidelines to maintain the moral and social
      perspectives. It is equally important to follow the scientific research
      methodology for the maximum gains from research experiments and projects.
      Interpretation of results of clinical experiments are hardly ever unequivocal,
      hence, there is a need for repetitive studies, systematic reviews and
      meta-analyses to reach definitive conclusions. It is important for busy
      physicians to adopt a scientific temper of logic and engage themselves in
      searching for answers to different research questions. It is always gainful to
      spare some time and resources for research out of a busy clinical practice. It is
      also worthwhile to go through a formal training programme in research methodology
      to improve capacity and competence to conduct meaningful research.
FAU - Jindal, S K
AU  - Jindal SK
AD  - Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and
      Research, Chandigarh, India. dr.skjindal@gmail.com
LA  - eng
PT  - Journal Article
PT  - Review
PL  - India
TA  - Indian J Chest Dis Allied Sci
JT  - The Indian journal of chest diseases & allied sciences
JID - 7612044
SB  - IM
MH  - *Biomedical Research/methods/organization & administration/standards
MH  - Ethics, Research
MH  - Humans
EDAT- 2012/09/27 06:00
MHDA- 2012/10/17 06:00
CRDT- 2012/09/27 06:00
PHST- 2012/09/27 06:00 [entrez]
PHST- 2012/09/27 06:00 [pubmed]
PHST- 2012/10/17 06:00 [medline]
PST - ppublish
SO  - Indian J Chest Dis Allied Sci. 2012 Jul-Sep;54(3):175-82.


PMID- 23008079
OWN - NLM
STAT- MEDLINE
DCOM- 20130107
LR  - 20120925
IS  - 1554-558X (Electronic)
IS  - 0894-1912 (Linking)
VI  - 32
IP  - 3
DP  - 2012 Summer
TI  - Development of a competency framework for quality improvement in family medicine:
      a qualitative study.
PG  - 174-80
LID - 10.1002/chp.21142 [doi]
AB  - OBJECTIVE: The aim of this study was to develop a comprehensive framework of
      quality improvement competencies for use in continuing professional development
      (CPD) and continuing medical education (CME) for European general practice/family
      medicine physicians (GPs/FDs). METHODS: The study was carried out in three
      phases: literature review, consensus development panels, and Delphi technique. An
      initial competencies framework was developed from an extensive literature review 
      focusing on literature in English from 2000 to 2011 and addressing quality
      improvement competencies for general practitioners in continuous education
      programs. Two rounds of reviews by consensus development panels were undertaken
      to evaluate and make changes to the initial draft competency framework. Then two 
      rounds of Delphi surveys were carried out in an effort to reach consensus on the 
      domains and competencies included in the framework. Our goal was for 90% to 100% 
      consensus. Both surveys were presented through SurveyMonkey, an online survey
      service, and sent by e-mail to members of the European Association for Quality
      and Patient Safety in General Practice/Family Medicine (EQuiP), a network
      organization of Wonca Europe. RESULTS: The Quality Improvement Competencies
      Framework was developed. It consists of a list of 35 competencies organized into 
      the following domains: Patient Care & Safety, Effectiveness & Efficiency, Equity 
      & Ethical Practice, Methods & Tools, Leadership & Management, and Continuing
      Professional Education. CONCLUSION: We believe that the framework can serve as a 
      useful tool for identifying gaps in knowledge and skills and guiding the
      development of CPD and CME curricula for GPs/FDs not only in Europe but also in
      other regions, including the United States and Canada, on the assumption that
      many of the core tasks of quality improvement would be relevant across multiple
      contexts.
CI  - Copyright (c) 2012 The Alliance for Continuing Education in the Health
      Professions, the Society for Academic Continuing Medical Education, and the
      Council on CME, Association for Hospital Medical Education.
FAU - Czabanowska, Katarzyna
AU  - Czabanowska K
AD  - Maastricht University, Faculty of Health, Medicine and Life Sciences, CAPHRI
      School of Public Health and Primary Care, Department of International Health,
      Maastricht, the Netherlands. kasia.czabanowska@maastrichtuniversity.nl
FAU - Klemenc-Ketis, Zalika
AU  - Klemenc-Ketis Z
FAU - Potter, Amanda
AU  - Potter A
FAU - Rochfort, Andree
AU  - Rochfort A
FAU - Tomasik, Tomasz
AU  - Tomasik T
FAU - Csiszar, Judit
AU  - Csiszar J
FAU - Van den Bussche, Piet
AU  - Van den Bussche P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Contin Educ Health Prof
JT  - The Journal of continuing education in the health professions
JID - 8805847
SB  - IM
MH  - Family Health/*standards
MH  - Humans
MH  - Qualitative Research
MH  - Quality Improvement/*organization & administration
EDAT- 2012/09/26 06:00
MHDA- 2013/01/08 06:00
CRDT- 2012/09/26 06:00
PHST- 2012/09/26 06:00 [entrez]
PHST- 2012/09/26 06:00 [pubmed]
PHST- 2013/01/08 06:00 [medline]
AID - 10.1002/chp.21142 [doi]
PST - ppublish
SO  - J Contin Educ Health Prof. 2012 Summer;32(3):174-80. doi: 10.1002/chp.21142.


PMID- 23007829
OWN - NLM
STAT- MEDLINE
DCOM- 20131202
LR  - 20120925
IS  - 1972-6007 (Electronic)
IS  - 0009-9074 (Linking)
VI  - 163
IP  - 4
DP  - 2012 Jul
TI  - [The perceived quality of routine daily communication in dialogues between health
      care workers].
PG  - e227-32
AB  - In our day-to-day professional experience as doctors and chemists, we have often 
      noted the poor quality of communication between us and other healthcare workers. 
      We have observed how this in turn can adversely affect communication with the
      patient, which not only results in poor service to patients themselves, but also 
      impairs the quality of our own work. Moreover, we are convinced that certain such
      behaviours are ubiquitous. We have therefore sought to evaluate this aspect of
      our professional life, using literature available on-line. The results reveal the
      existence of a large number of publications dedicated to relationships between
      different professions, and representing every possible position: from those
      frankly critical of other healthcare workers, to those seeking simply to
      understand these phenomena, to those planning strategies to overcome long-lasting
      animosities. Even the Italian Health Ministry, in its treatment of themes related
      to clinical risk, has devoted considerable attention to the quality of
      communication between healthcare workers. The conclusion we have reached is that 
      there are two areas which are crucial to the improvement of inter-professional
      relations, namely: sufficient training in these matters in University courses,
      and a shift in conflicting ethical positions, which often reflect individual
      professional experience.
FAU - Felicetti, V
AU  - Felicetti V
AD  - UOSD Farmaco-oncologia, Dipartimento interaziendale del Farmaco AO San Filippo
      Neri-ASL RMG, Tivoli, Italia. viviana.felicetti@gmail.com
FAU - Cifaldi, L
AU  - Cifaldi L
FAU - Cristina, G
AU  - Cristina G
FAU - Trecca, P
AU  - Trecca P
LA  - ita
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Qualita percepita della comunicazione nella daily routine: il dialogo tra le
      figure sanitarie.
PL  - Italy
TA  - Clin Ter
JT  - La Clinica terapeutica
JID - 0372604
SB  - IM
MH  - *Attitude of Health Personnel
MH  - *Communication
MH  - *Health Personnel
MH  - *Interprofessional Relations
MH  - Nurses
MH  - Pharmacists
MH  - Physicians
EDAT- 2012/09/26 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/09/26 06:00
PHST- 2012/09/26 06:00 [entrez]
PHST- 2012/09/26 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
PST - ppublish
SO  - Clin Ter. 2012 Jul;163(4):e227-32.


PMID- 23007382
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20130104
IS  - 1538-3679 (Electronic)
IS  - 0003-9926 (Linking)
VI  - 172
IP  - 19
DP  - 2012 Oct 22
TI  - Coping with critical drug shortages: an ethical approach for allocating scarce
      resources in hospitals.
PG  - 1494-9
LID - 10.1001/archinternmed.2012.4367 [doi]
AB  - The number of critical medication shortages in the United States has reached an
      unprecedented level, requiring decisions about allocating limited drug supplies. 
      Ad hoc decisions are susceptible to arbitrary judgments, revealing preformed
      biases for or against groups of people. Health care institutions lack
      standardized protocols for rationing scarce drugs. We describe the principles on 
      which an ethically justifiable policy of medication allocation during critical
      shortages was created at our hospital. Based on supportable scientific evidence
      and with all clinically similar patients treated as similarly deserving of
      consideration, drugs were distributed according to a hierarchy of clinical need
      and predicted efficacy. We explain the ethical rationale for the procedures we
      adopted, how the policy was implemented at a large academic medical center, and
      more than 1 year of experience with a number of different medications. Our
      experience has demonstrated the feasibility and utility of formulating a rational
      and ethically sound policy for scarce resource allocation in an academic teaching
      hospital that could be used in a variety of health care settings. The method has 
      proven to be reliable, workable, and acceptable to clinicians, staff, and
      patients.
FAU - Rosoff, Philip M
AU  - Rosoff PM
AD  - Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA. 
      philip.rosoff@duke.edu
FAU - Patel, Kuldip R
AU  - Patel KR
FAU - Scates, Ann
AU  - Scates A
FAU - Rhea, Gene
AU  - Rhea G
FAU - Bush, Paul W
AU  - Bush PW
FAU - Govert, Joseph A
AU  - Govert JA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Arch Intern Med
JT  - Archives of internal medicine
JID - 0372440
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
CIN - Arch Intern Med. 2012 Oct 22;172(19):1499-500. PMID: 23007059
MH  - Health Care Rationing/*ethics
MH  - Health Services Needs and Demand/*ethics
MH  - Hospitals/*ethics
MH  - Humans
MH  - Pharmaceutical Preparations/*supply & distribution
MH  - Resource Allocation/*ethics
MH  - *Social Justice
MH  - United States
EDAT- 2012/09/26 06:00
MHDA- 2013/03/13 06:00
CRDT- 2012/09/26 06:00
PHST- 2012/09/26 06:00 [entrez]
PHST- 2012/09/26 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
AID - 1362942 [pii]
AID - 10.1001/archinternmed.2012.4367 [doi]
PST - ppublish
SO  - Arch Intern Med. 2012 Oct 22;172(19):1494-9. doi:
      10.1001/archinternmed.2012.4367.


PMID- 23007323
OWN - NLM
STAT- MEDLINE
DCOM- 20130317
LR  - 20190221
IS  - 1531-4995 (Electronic)
IS  - 0023-852X (Linking)
VI  - 123
IP  - 1
DP  - 2013 Jan
TI  - Early glottic carcinoma treated by radiotherapy: defining a population for
      surgical salvage.
PG  - 171-6
LID - 10.1002/lary.23663 [doi]
AB  - OBJECTIVES/HYPOTHESIS: Not all patients with early Glottis squamous cell
      carcinoma will be cured by radiotherapy. This is an audit of a single center's
      experience with those patients who fail by this approach. STUDY DESIGN: This
      retrospective study was approved by the IRB (Institutional Review Board);
      eligibility criterion was patients treated between 1967 and December 2006, T(IS),
      T(1), T(2) N(0) SCC glottic carcinoma, with analysis occurring in 2009, and with 
      a minimum follow-up of 2 years. METHODS: The eligibility criteria for this
      ethics-approved study was that all patients started a course of radiotherapy for 
      early glottic laryngeal SCC. Data included in the Larynx Cancer database includes
      information from the Radiation Oncology Department notes, referral letters, and
      follow-up information. This is categorized into patient, disease, and treatment
      factors. RESULTS: Of 522 patients who commenced radiotherapy, local failure
      occurred in 105 patients; a salvage procedure was performed in 89, with surgery
      only in 83. For these 89 patients, the ultimate local control was 67%, with a
      larynx preservation procedure in 34%. Nodal failure occurred in 20 of the 522
      patients (4%). There was a much higher failure rate in patients unfit for surgery
      (10/26-38%). Laryngectomy was the main salvage procedure in 55 patients.
      CONCLUSIONS: Early recognition of local failure following radiotherapy for early 
      glottic carcinoma may avoid laryngectomy as a salvage procedure.
CI  - Copyright (c) 2012 The American Laryngological, Rhinological, and Otological
      Society, Inc.
FAU - Smee, Robert I
AU  - Smee RI
AD  - Department of Radiation Oncology, The Prince of Wales Cancer Centre, Randwick,
      New South Wales, Australia.
FAU - Williams, Janet R
AU  - Williams JR
FAU - Broadley, Kathryn
AU  - Broadley K
FAU - Bridger, G P
AU  - Bridger GP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120924
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
SB  - IM
MH  - Aged
MH  - Carcinoma, Squamous Cell/*radiotherapy/surgery
MH  - Female
MH  - Follow-Up Studies
MH  - Glottis/*pathology/surgery
MH  - Head and Neck Neoplasms/*radiotherapy/surgery
MH  - Humans
MH  - Laryngeal Neoplasms/pathology/*radiotherapy/surgery
MH  - Laryngectomy/*methods
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Retrospective Studies
MH  - Salvage Therapy/*methods
MH  - Squamous Cell Carcinoma of Head and Neck
MH  - Survival Rate
MH  - Treatment Failure
EDAT- 2012/09/26 06:00
MHDA- 2013/03/19 06:00
CRDT- 2012/09/26 06:00
PHST- 2012/07/23 00:00 [accepted]
PHST- 2012/09/26 06:00 [entrez]
PHST- 2012/09/26 06:00 [pubmed]
PHST- 2013/03/19 06:00 [medline]
AID - 10.1002/lary.23663 [doi]
PST - ppublish
SO  - Laryngoscope. 2013 Jan;123(1):171-6. doi: 10.1002/lary.23663. Epub 2012 Sep 24.


PMID- 23007313
OWN - NLM
STAT- MEDLINE
DCOM- 20140516
LR  - 20211021
IS  - 1432-1246 (Electronic)
IS  - 0340-0131 (Linking)
VI  - 86
IP  - 7
DP  - 2013 Oct
TI  - Ethical issues of genetic susceptibility testing for occupational diseases:
      opinions of trainees in a high-risk job.
PG  - 827-36
LID - 10.1007/s00420-012-0816-y [doi]
AB  - PURPOSE: Genetic research has opened up possibilities for identification of
      persons with an increased susceptibility for occupational disease. However,
      regulations considering the ethical issues that are inevitably associated with
      the use of genetic tests for susceptibility for occupational diseases are scarce.
      We investigated whether opinions of an intended stakeholder group, that is,
      student nurses, are sufficiently addressed by existing recommendations. METHODS: 
      Attitudes and opinions of Dutch student nurses toward a genetic test for
      susceptibility to occupational contact eczema were studied in a qualitative setup
      using focus groups, interviews and electronic questionnaires. The results were
      compared with guidelines and recommendations extracted from the literature.
      RESULTS: Sixty-nine percent of the student nurses said they would partake in a
      genetic test for susceptibility to occupational contact eczema when available.
      Concerns were expressed regarding the difficulty of interpreting test results,
      the utility of the test result in practice and the necessity of genetic tests for
      non-severe diseases. For the issue of privacy and confidentiality, the students
      expressed few worries and much confidence. The existing guidelines largely
      covered the students' opinions. Still, the data emphasized the need for good
      individual risk communication both before and after testing, taking into account 
      that the test concerns susceptibility. CONCLUSIONS: Comparing the students'
      statements with the issues addressed by the guidelines, we conclude that the
      guidelines should pay more attention to risk communication and practical advice
      accompanying the test results.
FAU - Visser, M J
AU  - Visser MJ
AD  - Coronel Institute of Occupational Health, Academic Medical Center, University of 
      Amsterdam, P.O. box 22700, 1100 DE, Amsterdam, The Netherlands,
      m.j.visser@amc.nl.
FAU - Rhebergen, M D F
AU  - Rhebergen MD
FAU - Kezic, S
AU  - Kezic S
FAU - van Dijk, F J H
AU  - van Dijk FJ
FAU - Willems, D L
AU  - Willems DL
FAU - Verberk, M M
AU  - Verberk MM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120925
PL  - Germany
TA  - Int Arch Occup Environ Health
JT  - International archives of occupational and environmental health
JID - 7512134
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Communication
MH  - Confidentiality
MH  - Dermatitis, Contact/*genetics
MH  - Dermatitis, Occupational/*genetics
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genetic Testing/*ethics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Occupational Health/ethics
MH  - Practice Guidelines as Topic
MH  - Risk Factors
MH  - Students, Nursing/*psychology
MH  - Young Adult
EDAT- 2012/09/26 06:00
MHDA- 2014/05/17 06:00
CRDT- 2012/09/26 06:00
PHST- 2012/03/26 00:00 [received]
PHST- 2012/08/30 00:00 [accepted]
PHST- 2012/09/26 06:00 [entrez]
PHST- 2012/09/26 06:00 [pubmed]
PHST- 2014/05/17 06:00 [medline]
AID - 10.1007/s00420-012-0816-y [doi]
PST - ppublish
SO  - Int Arch Occup Environ Health. 2013 Oct;86(7):827-36. doi:
      10.1007/s00420-012-0816-y. Epub 2012 Sep 25.


PMID- 23007260
OWN - NLM
STAT- MEDLINE
DCOM- 20121126
LR  - 20120925
IS  - 0392-0488 (Print)
IS  - 0392-0488 (Linking)
VI  - 147
IP  - 5
DP  - 2012 Oct
TI  - Ethical responsibility when dermatological signs reflect genetic disease.
PG  - 508-9
FAU - Arunachalam, M
AU  - Arunachalam M
FAU - Colucci, R
AU  - Colucci R
FAU - Galeone, M
AU  - Galeone M
FAU - Dragoni, F
AU  - Dragoni F
FAU - Berti, S
AU  - Berti S
FAU - Moretti, S
AU  - Moretti S
LA  - eng
PT  - Case Reports
PT  - Letter
PL  - Italy
TA  - G Ital Dermatol Venereol
JT  - Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa
      italiana di dermatologia e sifilografia
JID - 8102852
SB  - IM
MH  - *Bioethical Issues
MH  - Dermatology/*ethics
MH  - Female
MH  - Humans
MH  - Neurofibromatosis 1/*diagnosis/*genetics
MH  - Truth Disclosure/*ethics
MH  - Young Adult
EDAT- 2012/09/26 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/09/26 06:00
PHST- 2012/09/26 06:00 [entrez]
PHST- 2012/09/26 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - R23124322 [pii]
PST - ppublish
SO  - G Ital Dermatol Venereol. 2012 Oct;147(5):508-9.


PMID- 23007211
OWN - NLM
STAT- MEDLINE
DCOM- 20121119
LR  - 20120925
IS  - 0392-0488 (Print)
IS  - 0392-0488 (Linking)
VI  - 147
IP  - 4
DP  - 2012 Aug
TI  - Legal aspects of sexually transmitted diseases: abuse, partner notification and
      prosecution.
PG  - 357-71
AB  - Sexually transmitted diseases (STDs), with special emphasis to HIV infection,
      involve legal and ethical issues regarding informed consent to submit to a
      diagnostic, observance of professional secrecy in regard to partner(s) and
      community; legal troubles of particular difficulties are related to STD involving
      minors; lastly, physicians must be able to recognize the state of so called
      medical necessity. Knowledge and awareness of these related obligations are
      crucial to STD in medical practice; it is also important to allow for proper
      protection of victims of suspected sexual abuse under observation of healthcare. 
      With regard to this aspect should be emphasized that violence against women and
      minors is a worldwide problem that has not yet been sufficiently acknowledged.
      Italian legislation (Law n. 96/1996) against rapes finally gave significant
      relevance to sex crimes. When sexual abusers have to be evaluated some obstacles 
      may arise for lack of appropriate interdisciplinary approach, with insurance of
      the collection of biological samples, also related to STD diagnosis and alerts of
      legal authorities. Personal preconceptions may interfere with investigation if
      the biological evidences in children are few. In this regard, rules of document
      "Carta di Noto" drafted in 1996 and reviewed in July 2002 include some specific
      indications aiming to grant the reliability of the results of technical
      investigations and authenticity of the statements of the alleged victims.
FAU - Argo, A
AU  - Argo A
AD  - Department of Biopathology, Biotechnology and Forensic Medicine, University of
      Palermo, Palermo, Italy. antonella.argo@unipa.it
FAU - Zerbo, S
AU  - Zerbo S
FAU - Triolo, V
AU  - Triolo V
FAU - Averna, L
AU  - Averna L
FAU - D'Anna, T
AU  - D'Anna T
FAU - Nicosia, A
AU  - Nicosia A
FAU - Procaccianti, P
AU  - Procaccianti P
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - G Ital Dermatol Venereol
JT  - Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa
      italiana di dermatologia e sifilografia
JID - 8102852
SB  - IM
MH  - AIDS Serodiagnosis
MH  - Contact Tracing/*legislation & jurisprudence
MH  - Female
MH  - Forensic Medicine/*legislation & jurisprudence
MH  - Humans
MH  - *Law Enforcement
MH  - Rape/legislation & jurisprudence
MH  - Sex Offenses/*legislation & jurisprudence
MH  - *Sexually Transmitted Diseases/etiology
MH  - Violence/legislation & jurisprudence
EDAT- 2012/09/26 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/09/26 06:00
PHST- 2012/09/26 06:00 [entrez]
PHST- 2012/09/26 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - R23124381 [pii]
PST - ppublish
SO  - G Ital Dermatol Venereol. 2012 Aug;147(4):357-71.


PMID- 23007173
OWN - NLM
STAT- MEDLINE
DCOM- 20130506
LR  - 20211203
IS  - 1471-499X (Electronic)
IS  - 1471-4914 (Linking)
VI  - 18
IP  - 12
DP  - 2012 Dec
TI  - Ethical genetic research in Indigenous communities: challenges and successful
      approaches.
PG  - 702-8
LID - 10.1016/j.molmed.2012.08.003 [doi]
LID - S1471-4914(12)00164-5 [pii]
AB  - Indigenous populations, in common with all populations, stand to benefit from the
      potential of genetic research to lead to improvements in diagnostic and
      therapeutic tools for a wide range of complex diseases. However, many Indigenous 
      communities, especially ones that are isolated, are not included in genetic
      research efforts. This situation is largely a consequence of the challenges of
      ethically conducting genetic research in Indigenous communities and compounded by
      Indigenous peoples' negative past experiences with genetic issues. To examine
      ways of addressing these challenges, we review one investigation of a cancer
      cluster in remote Aboriginal communities in Arnhem Land, Australia. Our
      experiences demonstrate that genetic research can be both ethically and
      successfully conducted with Indigenous communities by respecting the authority of
      the community, involving community members, and including regular community
      review throughout the research process.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - McWhirter, Rebekah E
AU  - McWhirter RE
AD  - Menzies School of Health Research, Charles Darwin University, Darwin, NT 0811,
      Australia. rebekah.mcwhirter@utas.edu.au
FAU - Mununggirritj, Djapirri
AU  - Mununggirritj D
FAU - Marika, Dipililnga
AU  - Marika D
FAU - Dickinson, Joanne L
AU  - Dickinson JL
FAU - Condon, John R
AU  - Condon JR
LA  - eng
PT  - Journal Article
PT  - Portrait
PT  - Research Support, Non-U.S. Gov't
DEP - 20120921
PL  - England
TA  - Trends Mol Med
JT  - Trends in molecular medicine
JID - 100966035
SB  - IM
MH  - Community-Based Participatory Research/*methods
MH  - Female
MH  - Genetic Research/*ethics
MH  - Humans
MH  - Information Dissemination/methods
MH  - Informed Consent/ethics
MH  - Native Hawaiian or Other Pacific Islander/*genetics
MH  - Northern Territory
MH  - Vulvar Neoplasms/*genetics
EDAT- 2012/09/26 06:00
MHDA- 2013/05/07 06:00
CRDT- 2012/09/26 06:00
PHST- 2012/04/30 00:00 [received]
PHST- 2012/08/16 00:00 [revised]
PHST- 2012/08/27 00:00 [accepted]
PHST- 2012/09/26 06:00 [entrez]
PHST- 2012/09/26 06:00 [pubmed]
PHST- 2013/05/07 06:00 [medline]
AID - S1471-4914(12)00164-5 [pii]
AID - 10.1016/j.molmed.2012.08.003 [doi]
PST - ppublish
SO  - Trends Mol Med. 2012 Dec;18(12):702-8. doi: 10.1016/j.molmed.2012.08.003. Epub
      2012 Sep 21.


PMID- 23006994
OWN - NLM
STAT- MEDLINE
DCOM- 20130402
LR  - 20120925
IS  - 1881-7831 (Print)
IS  - 1881-7831 (Linking)
VI  - 6
IP  - 4
DP  - 2012 Aug
TI  - Animal welfare and use of silkworm as a model animal.
PG  - 226-9
AB  - Sacrificing model animals is required for developing effective drugs before being
      used in human beings. In Japan today, at least 4,210,000 mice and other mammals
      are sacrificed to a total of 6,140,000 per year for the purpose of medical
      studies. All the animals treated in Japan, including test animals, are managed
      under control of "Act on Welfare and Management of Animals". Under the principle 
      of this Act, no person shall kill, injure, or inflict cruelty on animals without 
      due cause. "Animal" addressed in the Act can be defined as a "vertebrate animal".
      If we can make use of invertebrate animals in testing instead of vertebrate ones,
      that would be a remarkable solution for the issue of animal welfare. Furthermore,
      there are numerous advantages of using invertebrate animal models: less space and
      small equipment are enough for taking care of a large number of animals and thus 
      are cost-effective, they can be easily handled, and many biological processes and
      genes are conserved between mammals and invertebrates. Today, many invertebrates 
      have been used as animal models, but silkworms have many beneficial traits
      compared to mammals as well as other insects. In a Genome Pharmaceutical
      Institute's study, we were able to achieve a lot making use of silkworms as model
      animals. We would like to suggest that pharmaceutical companies and institutes
      consider the use of the silkworm as a model animal which is efficacious both for 
      financial value by cost cutting and ethical aspects in animals' welfare.
FAU - Sekimizu, N
AU  - Sekimizu N
AD  - Genome Pharmaceuticals Institute Co., Ltd., Tokyo, Japan.
      nsekimizu@genome-pharm.jp
FAU - Paudel, A
AU  - Paudel A
FAU - Hamamoto, H
AU  - Hamamoto H
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Drug Discov Ther
JT  - Drug discoveries & therapeutics
JID - 101493809
SB  - IM
MH  - Animal Use Alternatives/economics/*ethics/*methods
MH  - *Animal Welfare
MH  - Animals
MH  - Bioethics
MH  - *Bombyx
MH  - Drug Evaluation, Preclinical/economics/*ethics/*methods
MH  - Drug Industry
MH  - Ethics, Research
MH  - Japan
EDAT- 2012/09/26 06:00
MHDA- 2013/04/03 06:00
CRDT- 2012/09/26 06:00
PHST- 2012/09/26 06:00 [entrez]
PHST- 2012/09/26 06:00 [pubmed]
PHST- 2013/04/03 06:00 [medline]
AID - 580 [pii]
PST - ppublish
SO  - Drug Discov Ther. 2012 Aug;6(4):226-9.


PMID- 23006770
OWN - NLM
STAT- MEDLINE
DCOM- 20141006
LR  - 20131114
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 13
IP  - 3
DP  - 2013 Dec
TI  - Animal research ethics in Africa: is Tanzania making progress?
PG  - 158-62
LID - 10.1111/dewb.12001 [doi]
AB  - The significance of animals in research cannot be over-emphasized. The use of
      animals for research and training in research centres, hospitals and schools is
      progressively increasing. Advances in biotechnology to improve animal
      productivity require animal research. Drugs being developed and new interventions
      or therapies being invented for cure and palliation of all sorts of animal
      diseases and conditions need to be tested in animals for their safety and
      efficacy at some stages of their development. Drugs and interventions for human
      use pass through a similar development process and must be tested pre-clinically 
      in laboratory animals before clinical trials in humans can be conducted.
      Therefore, animals are important players in research processes which directly and
      indirectly benefit animals and humans. However, questions remain as to whether
      these uses of animals consider the best interests of animals themselves. Various 
      research and training institutions in Tanzania have established some guidelines
      on animal use, including establishing animal ethics committees. However, most
      institutions have not established oversight committees. In institutions where
      there may be guidelines and policies, there are no responsible committees or
      units to directly oversee if and how these guidelines and policies are enforced; 
      thus, implementation becomes difficult or impossible. This paper endeavours to
      raise some issues associated with the responsible use of animals in research and 
      training in Tanzania and highlights suggestions for improvement of deficiencies
      that exist in order to bridge the gap between what ought to be practised and what
      is practised.
CI  - (c) 2012 John Wiley & Sons Ltd.
FAU - Seth, Misago
AU  - Seth M
FAU - Saguti, Fredy
AU  - Saguti F
LA  - eng
PT  - Journal Article
DEP - 20120924
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
SB  - IM
MH  - Africa
MH  - Animal Experimentation/*ethics
MH  - Animals
MH  - Education, Professional/standards
MH  - *Ethics Committees, Research
MH  - *Ethics, Research/education
MH  - Government Regulation
MH  - Health Services Needs and Demand/ethics
MH  - Humans
MH  - Tanzania
OTO - NOTNLM
OT  - Animal ethics
OT  - Animal research
OT  - Animal research ethics
OT  - Animals
OT  - Tanzania
EDAT- 2012/09/26 06:00
MHDA- 2014/10/07 06:00
CRDT- 2012/09/26 06:00
PHST- 2012/09/26 06:00 [entrez]
PHST- 2012/09/26 06:00 [pubmed]
PHST- 2014/10/07 06:00 [medline]
AID - 10.1111/dewb.12001 [doi]
PST - ppublish
SO  - Dev World Bioeth. 2013 Dec;13(3):158-62. doi: 10.1111/dewb.12001. Epub 2012 Sep
      24.


PMID- 23006701
OWN - NLM
STAT- MEDLINE
DCOM- 20121204
LR  - 20120925
IS  - 1552-6259 (Electronic)
IS  - 0003-4975 (Linking)
VI  - 94
IP  - 4
DP  - 2012 Oct
TI  - External tracheal stabilization technique for acquired tracheomalacia using a
      tailored silicone tube.
PG  - 1356-8
LID - 10.1016/j.athoracsur.2012.04.133 [doi]
LID - S0003-4975(12)01177-0 [pii]
AB  - Here, we describe an external tracheal stabilization technique used in a patient 
      with tracheomalacia. A 56-year-old man presented with tracheomalacia due to
      prolonged mechanical ventilation. The malacic tracheal segment was approximately 
      2 cm in length. The malacic segment was covered with a silicone tube sutured in
      place using Prolene sutures (Ethicon, Somerville, NJ). Several anchoring sutures 
      were placed between the tracheal mucosa and the silicone tube without violating
      the mucosal continuity. The patient was discharged on postoperative day 5 without
      complication. This method of external tracheal stabilization is a less invasive
      alternative for the management of this particular patient.
CI  - Copyright (c) 2012 The Society of Thoracic Surgeons. Published by Elsevier Inc.
      All rights reserved.
FAU - Cho, Jong Ho
AU  - Cho JH
AD  - Department of Thoracic and Cardiovascular Surgery, Samsung Medical center,
      Sungkyunkwan University School of Medicine, Seoul, Korea.
FAU - Kim, HoJoong
AU  - Kim H
FAU - Kim, Jhingook
AU  - Kim J
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Netherlands
TA  - Ann Thorac Surg
JT  - The Annals of thoracic surgery
JID - 15030100R
RN  - 0 (Silicone Elastomers)
SB  - IM
MH  - Equipment Design
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Silicone Elastomers
MH  - *Stents
MH  - Thoracic Surgical Procedures/*methods
MH  - Trachea/*surgery
MH  - Tracheomalacia/diagnosis/*surgery
EDAT- 2012/09/26 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/09/26 06:00
PHST- 2012/01/02 00:00 [received]
PHST- 2012/04/12 00:00 [revised]
PHST- 2012/04/23 00:00 [accepted]
PHST- 2012/09/26 06:00 [entrez]
PHST- 2012/09/26 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - S0003-4975(12)01177-0 [pii]
AID - 10.1016/j.athoracsur.2012.04.133 [doi]
PST - ppublish
SO  - Ann Thorac Surg. 2012 Oct;94(4):1356-8. doi: 10.1016/j.athoracsur.2012.04.133.


PMID- 23006145
OWN - NLM
STAT- MEDLINE
DCOM- 20130730
LR  - 20220317
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 13
DP  - 2012 Sep 24
TI  - Developing a guideline for clinical trial protocol content: Delphi consensus
      survey.
PG  - 176
LID - 10.1186/1745-6215-13-176 [doi]
AB  - BACKGROUND: Recent evidence has highlighted deficiencies in clinical trial
      protocols, having implications for many groups. Existing guidelines for
      randomized clinical trial (RCT) protocol content vary substantially and most do
      not describe systematic methodology for their development. As one of three
      prespecified steps for the systematic development of a guideline for trial
      protocol content, the objective of this study was to conduct a three-round Delphi
      consensus survey to develop and refine minimum content for RCT protocols.
      METHODS: Panellists were identified using a multistep iterative approach, met
      prespecified minimum criteria and represented key stakeholders who develop or use
      clinical trial protocols. They were asked to rate concepts for importance in a
      minimum set of items for RCT protocols. The main outcome measures were degree of 
      importance (scale of 1 to 10; higher scores indicating higher importance) and
      level of consensus for items. Results were presented as medians, interquartile
      ranges, counts and percentages. RESULTS: Ninety-six expert panellists
      participated in the Delphi consensus survey including trial investigators,
      methodologists, research ethics board members, funders, industry, regulators and 
      journal editors. Response rates were between 88 and 93% per round. Overall,
      panellists rated 63 of 88 concepts of high importance (of which 50 had a 25th
      percentile rating of 8 or greater), 13 of moderate importance (median 6 or 7) and
      12 of low importance (median less than or equal to 5) for minimum trial protocol 
      content. General and item-specific comments and subgroup results provided
      valuable insight for further discussions. CONCLUSIONS: This Delphi process
      achieved consensus from a large panel of experts from diverse stakeholder groups 
      on essential content for RCT protocols. It also highlights areas of divergence.
      These results, complemented by other empirical research and consensus meetings,
      are helping guide the development of a guideline for protocol content.
FAU - Tetzlaff, Jennifer Marie
AU  - Tetzlaff JM
AD  - Ottawa Methods Centre, Clinical Epidemiology Program, Ottawa Hospital Research
      Institute, Ottawa, ON, Canada. jtetzlaff@ohri.ca
FAU - Moher, David
AU  - Moher D
FAU - Chan, An-Wen
AU  - Chan AW
LA  - eng
PT  - Journal Article
DEP - 20120924
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
SB  - IM
MH  - *Clinical Protocols
MH  - Data Collection
MH  - *Delphi Technique
MH  - Humans
MH  - *Practice Guidelines as Topic
MH  - *Randomized Controlled Trials as Topic
PMC - PMC3533747
EDAT- 2012/09/26 06:00
MHDA- 2013/07/31 06:00
CRDT- 2012/09/26 06:00
PHST- 2012/03/31 00:00 [received]
PHST- 2012/09/07 00:00 [accepted]
PHST- 2012/09/26 06:00 [entrez]
PHST- 2012/09/26 06:00 [pubmed]
PHST- 2013/07/31 06:00 [medline]
AID - 1745-6215-13-176 [pii]
AID - 10.1186/1745-6215-13-176 [doi]
PST - epublish
SO  - Trials. 2012 Sep 24;13:176. doi: 10.1186/1745-6215-13-176.


PMID- 23006035
OWN - NLM
STAT- MEDLINE
DCOM- 20140127
LR  - 20220309
IS  - 1366-5847 (Electronic)
IS  - 0014-0139 (Linking)
VI  - 56
IP  - 3
DP  - 2013
TI  - Ergonomics and sustainability: towards an embrace of complexity and emergence.
PG  - 357-64
LID - 10.1080/00140139.2012.718799 [doi]
AB  - Technology offers a promising route to a sustainable future, and ergonomics can
      serve a vital role. The argument of this article is that the lasting success of
      sustainability initiatives in ergonomics hinges on an examination of ergonomics' 
      own epistemology and ethics. The epistemology of ergonomics is fundamentally
      empiricist and positivist. This places practical constraints on its ability to
      address important issues such as sustainability, emergence and complexity. The
      implicit ethical position of ergonomics is one of neutrality, and its positivist 
      epistemology generally puts value-laden questions outside the parameters of what 
      it sees as scientific practice. We argue, by contrast, that a discipline that
      deals with both technology and human beings cannot avoid engaging with questions 
      of complexity and emergence and seeking innovative ways of addressing these
      issues. PRACTITIONER SUMMARY: Ergonomics has largely modelled its research on a
      reductive science, studying parts and problems to fix. In sustainability efforts,
      this can lead to mere local adaptations with a negative effect on global
      sustainability. Ergonomics must consider quality of life globally, appreciating
      complexity and emergent effects of local relationships.
FAU - Dekker, Sidney W A
AU  - Dekker SW
AD  - School of Humanities, Griffith University, 170 Kessels Road, Nathan Campus, QLD
      4111, Australia. s.dekker@griffith.edu.au
FAU - Hancock, Peter A
AU  - Hancock PA
FAU - Wilkin, Peter
AU  - Wilkin P
LA  - eng
PT  - Journal Article
DEP - 20120925
PL  - England
TA  - Ergonomics
JT  - Ergonomics
JID - 0373220
SB  - IM
MH  - *Conservation of Natural Resources
MH  - Ergonomics/*ethics
MH  - Humans
MH  - *Knowledge
MH  - Technology
EDAT- 2012/09/26 06:00
MHDA- 2014/01/28 06:00
CRDT- 2012/09/26 06:00
PHST- 2012/09/26 06:00 [entrez]
PHST- 2012/09/26 06:00 [pubmed]
PHST- 2014/01/28 06:00 [medline]
AID - 10.1080/00140139.2012.718799 [doi]
PST - ppublish
SO  - Ergonomics. 2013;56(3):357-64. doi: 10.1080/00140139.2012.718799. Epub 2012 Sep
      25.


PMID- 23005912
OWN - NLM
STAT- MEDLINE
DCOM- 20140127
LR  - 20220309
IS  - 1366-5847 (Electronic)
IS  - 0014-0139 (Linking)
VI  - 56
IP  - 3
DP  - 2013
TI  - The role of anthropometry in designing for sustainability.
PG  - 422-39
LID - 10.1080/00140139.2012.718801 [doi]
AB  - An understanding of human factors and ergonomics facilitates the design of
      artefacts, tasks and environments that fulfil their users' physical and cognitive
      requirements. Research in these fields furthers the goal of efficiently
      accommodating the desired percentage of user populations through enhanced
      awareness and modelling of human variability. Design for sustainability (DfS)
      allows for these concepts to be leveraged in the broader context of designing to 
      minimise negative impacts on the environment. This paper focuses on anthropometry
      and proposes three ways in which its consideration is relevant to DfS: reducing
      raw material consumption, increasing usage lifetimes and ethical human resource
      considerations. This is demonstrated through the application of anthropometry
      synthesis, virtual fitting, and sizing and adjustability allocation methods in
      the design of an industrial workstation seat for use in five distinct global
      populations. This work highlights the importance of and opportunities for using
      ergonomic design principles in DfS efforts. PRACTITIONER SUMMARY: This research
      demonstrates the relevance of some anthropometry-based ergonomics concepts to the
      field of design for sustainability. A global design case study leverages human
      variability considerations in furthering three sustainable design goals: reducing
      raw material consumption, increasing usage lifetimes and incorporating ethical
      human resource considerations in design.
FAU - Nadadur, Gopal
AU  - Nadadur G
AD  - Department of Mechanical Engineering, Penn State University, University Park, PA,
      USA. gzn103@psu.edu
FAU - Parkinson, Matthew B
AU  - Parkinson MB
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20120925
PL  - England
TA  - Ergonomics
JT  - Ergonomics
JID - 0373220
SB  - IM
MH  - *Anthropometry
MH  - *Conservation of Natural Resources
MH  - Equipment Design
MH  - *Ergonomics
MH  - Humans
MH  - *Interior Design and Furnishings
EDAT- 2012/09/26 06:00
MHDA- 2014/01/28 06:00
CRDT- 2012/09/26 06:00
PHST- 2012/09/26 06:00 [entrez]
PHST- 2012/09/26 06:00 [pubmed]
PHST- 2014/01/28 06:00 [medline]
AID - 10.1080/00140139.2012.718801 [doi]
PST - ppublish
SO  - Ergonomics. 2013;56(3):422-39. doi: 10.1080/00140139.2012.718801. Epub 2012 Sep
      25.


PMID- 23004237
OWN - NLM
STAT- MEDLINE
DCOM- 20140121
LR  - 20130712
IS  - 1471-6712 (Electronic)
IS  - 0283-9318 (Linking)
VI  - 27
IP  - 3
DP  - 2013 Sep
TI  - Hermeneutic reading of classic texts.
PG  - 757-64
LID - 10.1111/j.1471-6712.2012.01080.x [doi]
AB  - The purpose of this article is to broaden the understandinfg of the hermeneutic
      reading of classic texts. The aim is to show how the choice of a specific
      scientific tradition in conjunction with a methodological approach creates the
      foundation that clarifies the actual realization of the reading. This hermeneutic
      reading of classic texts is inspired by Gadamer's notion that it is the
      researcher's own research tradition and a clearly formulated theoretical
      fundamental order that shape the researcher's attitude towards texts and create
      the starting point that guides all reading, uncovering and interpretation. The
      researcher's ethical position originates in a will to openness towards what is
      different in the text and which constantly sets the researcher's preunderstanding
      and research tradition in movement. It is the researcher's attitude towards the
      text that allows the text to address, touch and arouse wonder. Through a
      flexible, lingering and repeated reading of classic texts, what is different
      emerges with a timeless value. The reading of classic texts is an act that may
      rediscover and create understanding for essential dimensions and of human beings'
      reality on a deeper level. The hermeneutic reading of classic texts thus brings
      to light constantly new possibilities of uncovering for a new envisioning and
      interpretation for a new understanding of the essential concepts and phenomena
      within caring science.
CI  - (c) 2012 The Authors Scandinavian Journal of Caring Sciences (c) 2012 Nordic
      College of Caring Science.
FAU - Koskinen, Camilla A-L
AU  - Koskinen CA
AD  - Department of Caring Science, Abo Akademi University, Vaasa, Finland.
      camilla.koskinen@abo.fi
FAU - Lindstrom, Unni A
AU  - Lindstrom UA
LA  - eng
PT  - Journal Article
DEP - 20120924
PL  - Sweden
TA  - Scand J Caring Sci
JT  - Scandinavian journal of caring sciences
JID - 8804206
MH  - *Philosophy, Nursing
OTO - NOTNLM
OT  - Gadamer
OT  - caring science
OT  - classic texts
OT  - hermeneutic reading
EDAT- 2012/09/26 06:00
MHDA- 2014/01/22 06:00
CRDT- 2012/09/26 06:00
PHST- 2012/06/13 00:00 [received]
PHST- 2012/07/20 00:00 [accepted]
PHST- 2012/09/26 06:00 [entrez]
PHST- 2012/09/26 06:00 [pubmed]
PHST- 2014/01/22 06:00 [medline]
AID - 10.1111/j.1471-6712.2012.01080.x [doi]
PST - ppublish
SO  - Scand J Caring Sci. 2013 Sep;27(3):757-64. doi: 10.1111/j.1471-6712.2012.01080.x.
      Epub 2012 Sep 24.


PMID- 23002981
OWN - NLM
STAT- MEDLINE
DCOM- 20130207
LR  - 20120925
IS  - 1744-8395 (Electronic)
IS  - 1476-0584 (Linking)
VI  - 11
IP  - 8
DP  - 2012 Aug
TI  - Vaccination against influenza: role and limitations in pandemic intervention
      plans.
PG  - 1009-19
AB  - Influenza pandemics occur periodically and the subtype of the next pandemic
      strain cannot be predicted. Vaccination remains a critical intervention during
      pandemics, but current production technology requires several months to develop
      sufficient vaccine to meet anticipated worldwide need. Candidate prepandemic
      vaccines for use in population priming or rapid deployment during an epidemic are
      in development but are subtype specific and logistical obstacles to timely
      distribution exist. Intensive research is underway to identify a universal
      vaccine, providing protection against all known influenza strains based on shared
      epitopes. Vaccine access is expected to be limited during early response to a
      pandemic, necessitating ethical vaccine distribution plans for within-country and
      global allocation. Mass vaccination plans must be in place prior to an event to
      ensure appropriate infrastructures are in place. Carefully crafted education
      campaigns regarding pandemic vaccine safety and efficacy should aid in maximizing
      pandemic vaccine uptake during a future event.
FAU - Rebmann, Terri
AU  - Rebmann T
AD  - Institute for Biosecurity, Saint Louis University, School of Public Health, St
      Louis, MO 63104, USA. rebmannt@slu.edu
FAU - Zelicoff, Alan
AU  - Zelicoff A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Expert Rev Vaccines
JT  - Expert review of vaccines
JID - 101155475
RN  - 0 (Influenza Vaccines)
SB  - IM
MH  - Antigenic Variation
MH  - Disease Transmission, Infectious/prevention & control
MH  - Health Knowledge, Attitudes, Practice
MH  - Health Policy/legislation & jurisprudence
MH  - Humans
MH  - Immunization Programs/legislation & jurisprudence/*organization & administration
MH  - Influenza A Virus, H1N1 Subtype/immunology/pathogenicity
MH  - Influenza Vaccines/administration & dosage/immunology/*supply & distribution
MH  - Influenza, Human/immunology/*prevention & control
MH  - Mass Vaccination/ethics/legislation & jurisprudence/*methods
MH  - Pandemics/*prevention & control
MH  - Randomized Controlled Trials as Topic
MH  - Reassortant Viruses/immunology/pathogenicity
EDAT- 2012/09/26 06:00
MHDA- 2013/02/08 06:00
CRDT- 2012/09/26 06:00
PHST- 2012/09/26 06:00 [entrez]
PHST- 2012/09/26 06:00 [pubmed]
PHST- 2013/02/08 06:00 [medline]
AID - 10.1586/erv.12.63 [doi]
PST - ppublish
SO  - Expert Rev Vaccines. 2012 Aug;11(8):1009-19. doi: 10.1586/erv.12.63.


PMID- 23002580
OWN - NLM
STAT- MEDLINE
DCOM- 20121018
LR  - 20191112
IS  - 1054-6863 (Print)
IS  - 1054-6863 (Linking)
VI  - 22
IP  - 2
DP  - 2012 Jun
TI  - Values and uncertainties in the predictions of global climate models.
PG  - 111-37
AB  - Over the last several years, there has been an explosion of interest and
      attention devoted to the problem of Uncertainty Quantification (UQ) in climate
      science-that is, to giving quantitative estimates of the degree of uncertainty
      associated with the predictions of global and regional climate models. The
      technical challenges associated with this project are formidable, and so the
      statistical community has understandably devoted itself primarily to overcoming
      them. But even as these technical challenges are being met, a number of
      persistent conceptual difficulties remain. So why is UQ so important in climate
      science? UQ, I would like to argue, is first and foremost a tool for
      communicating knowledge from experts to policy makers in a way that is meant to
      be free from the influence of social and ethical values. But the standard ways of
      using probabilities to separate ethical and social values from scientific
      practice cannot be applied in a great deal of climate modeling, because the roles
      of values in creating the models cannot be discerned after the fact-the models
      are too complex and the result of too much distributed epistemic labor. I argue, 
      therefore, that typical approaches for handling ethical/social values in science 
      do not work well here.
FAU - Winsberg, Eric
AU  - Winsberg E
AD  - University of South Florida, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Kennedy Inst Ethics J
JT  - Kennedy Institute of Ethics journal
JID - 9109135
SB  - IM
MH  - Climate Change
MH  - *Climatic Processes
MH  - Democracy
MH  - *Forecasting
MH  - Humans
MH  - Knowledge
MH  - *Models, Theoretical
MH  - Predictive Value of Tests
MH  - Probability
MH  - *Social Values
MH  - *Uncertainty
EDAT- 2012/09/26 06:00
MHDA- 2012/10/19 06:00
CRDT- 2012/09/26 06:00
PHST- 2012/09/26 06:00 [entrez]
PHST- 2012/09/26 06:00 [pubmed]
PHST- 2012/10/19 06:00 [medline]
AID - 10.1353/ken.2012.0008 [doi]
PST - ppublish
SO  - Kennedy Inst Ethics J. 2012 Jun;22(2):111-37. doi: 10.1353/ken.2012.0008.


PMID- 23002578
OWN - NLM
STAT- MEDLINE
DCOM- 20121018
LR  - 20191112
IS  - 1054-6863 (Print)
IS  - 1054-6863 (Linking)
VI  - 22
IP  - 2
DP  - 2012 Jun
TI  - Science, expertise, and democracy.
PG  - 83-90
AB  - The combination of government's significant involvement in science, science's
      significant effects on the public, and public ignorance (of both politics and
      science) raise important challenges for reconciling scientific expertise with
      democratic governance. Nevertheless, there have recently been a variety of
      encouraging efforts to make scientific activity more responsive to social values 
      and to develop citizens' capacity to engage in more effective democratic
      governance of science. This essay introduces a special issue of the Kennedy
      Institute of Ethics Journal, "Science, Expertise, and Democracy," consisting of
      five papers that developed from the inaugural Three Rivers Philosophy conference 
      held at the University of South Carolina in April 2011. The pieces range from a
      general analysis of the in-principle compatibility of scientific expertise and
      democracy to much more concrete studies of the intersection between scientific
      practices and democratic values in areas such as weight-of-evidence analysis,
      climate science, and studies of locally undesirable land uses.
FAU - Weinberg, Justin
AU  - Weinberg J
AD  - University of South Carolina, USA.
FAU - Elliott, Kevin C
AU  - Elliott KC
LA  - eng
PT  - Introductory Journal Article
PL  - United States
TA  - Kennedy Inst Ethics J
JT  - Kennedy Institute of Ethics journal
JID - 9109135
SB  - IM
MH  - Climatic Processes
MH  - *Democracy
MH  - Environmental Exposure/prevention & control
MH  - Evidence-Based Practice
MH  - *Government
MH  - Humans
MH  - Knowledge
MH  - *Natural Science Disciplines
MH  - *Philosophy
MH  - *Politics
MH  - Public Opinion
MH  - *Social Values
EDAT- 2012/09/26 06:00
MHDA- 2012/10/19 06:00
CRDT- 2012/09/26 06:00
PHST- 2012/09/26 06:00 [entrez]
PHST- 2012/09/26 06:00 [pubmed]
PHST- 2012/10/19 06:00 [medline]
AID - 10.1353/ken.2012.0006 [doi]
PST - ppublish
SO  - Kennedy Inst Ethics J. 2012 Jun;22(2):83-90. doi: 10.1353/ken.2012.0006.


PMID- 23002295
OWN - NLM
STAT- MEDLINE
DCOM- 20121127
LR  - 20211021
IS  - 2048-8343 (Electronic)
IS  - 0025-7273 (Linking)
VI  - 56
IP  - 2
DP  - 2012 Apr
TI  - Sexological deliberation and social engineering: Albert Moll and the
      sterilisation debate in late imperial and Weimar Germany.
PG  - 237-54
AB  - The physician and sexologist Albert Moll, from Berlin, was one of the main
      protagonists within the German discourse on the opportunities and dangers of
      social engineering, by eugenic interventions into human life in general, as well 
      as into reproductive hygiene and healthcare policy in particular. One of the main
      sexological topics that were discussed intensively during the late-Wilhelminian
      German Reich and the Weimar Republic was the question of the legalisation of
      voluntary and compulsory sterilisations on the basis of medical, social, eugenic,
      economic or criminological indications. As is clear from Moll's conservative
      principles of medical ethics, and his conviction that the genetic knowledge
      required for eugenically indicated sterilisations was not yet sufficiently
      elaborated, he had doubts and worries about colleagues who were exceedingly
      zealous about these surgical sterilisations--especially Gustav Boeters from
      Saxony.
FAU - Bryant, Thomas
AU  - Bryant T
AD  - Ramlerstrasse 32, D-13355 Berlin, Germany. post@thomas-bryant.de
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - England
TA  - Med Hist
JT  - Medical history
JID - 0401052
SB  - IM
MH  - Dissent and Disputes/*history
MH  - Ethics, Medical/*history
MH  - Eugenics/*history
MH  - Genetic Diseases, Inborn/history/prevention & control
MH  - Germany
MH  - History, 19th Century
MH  - History, 20th Century
MH  - Humans
MH  - Sterilization, Reproductive/*history/legislation & jurisprudence
PMC - PMC3381532
OTO - NOTNLM
OT  - Albert Moll
OT  - Castration
OT  - Gesetz zur Verhutung erbkranken Nachwuchses
OT  - Gustav Boeters
OT  - Sexology
OT  - Sterilisation
EDAT- 2012/09/25 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/09/25 06:00
PHST- 2012/09/25 06:00 [entrez]
PHST- 2012/09/25 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1017/mdh.2011.35 [doi]
AID - 00035 [pii]
PST - ppublish
SO  - Med Hist. 2012 Apr;56(2):237-54. doi: 10.1017/mdh.2011.35.


PMID- 23002294
OWN - NLM
STAT- MEDLINE
DCOM- 20121127
LR  - 20211021
IS  - 2048-8343 (Electronic)
IS  - 0025-7273 (Linking)
VI  - 56
IP  - 2
DP  - 2012 Apr
TI  - 'God's ethicist': Albert Moll and his medical ethics in theory and practice.
PG  - 217-36
AB  - In 1902, Albert Moll, who at that time ran a private practice for nervous
      diseases in Berlin, published his comprehensive book on medical ethics, Arztliche
      Ethik. Based on the concept of a contractual relationship between doctor and
      client, it gave more room to the self-determination of patients than the
      contemporary, usually rather paternalistic, works of this genre. In the first
      part of the present paper this is illustrated by examining Moll's views and
      advice on matters such as truthfulness towards patients, euthanasia, and
      abortion. The second part of this article discusses how Moll engaged with the
      then publicly debated issues of experimentation on hospital patients and the
      'trade' of foreign private patients between agents and medical consultants. In
      both matters Moll collected evidence of unethical practices and tried to use it
      to bring about change without damaging his or the profession's reputation.
      However, with his tactical manoeuvres, Moll made no friends for himself among his
      colleagues or the authorities; his book on ethics also met with a generally cool 
      response from the medical profession and seems to have been more appreciated by
      lawyers than by other doctors.
FAU - Maehle, Andreas-Holger
AU  - Maehle AH
AD  - Centre for the History of Medicine and Disease, Wolfson Research Institute,
      Durham University, Queen's Campus, Stockton TS17 6BH, UK. a.h.maehle@durham.ac.uk
LA  - eng
PT  - Biography
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Med Hist
JT  - Medical history
JID - 0401052
SB  - IM
MH  - Berlin
MH  - Ethical Theory/*history
MH  - Ethics, Medical/*history
MH  - History, 20th Century
MH  - Humans
MH  - Practice Patterns, Physicians'/ethics/*history
PS  - Moll A
FPS - Moll, Albert
PMC - PMC3381533
OTO - NOTNLM
OT  - Abortion
OT  - Albert Moll
OT  - Euthanasia
OT  - Human Experimentation
OT  - Medical Ethics
OT  - Truth-telling
EDAT- 2012/09/25 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/09/25 06:00
PHST- 2012/09/25 06:00 [entrez]
PHST- 2012/09/25 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1017/mdh.2011.34 [doi]
AID - 00034 [pii]
PST - ppublish
SO  - Med Hist. 2012 Apr;56(2):217-36. doi: 10.1017/mdh.2011.34.


PMID- 23001949
OWN - NLM
STAT- MEDLINE
DCOM- 20130227
LR  - 20151119
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 12
DP  - 2012 Dec
TI  - Medicine, the media and political interests.
PG  - 768-70
LID - 10.1136/medethics-2012-100875 [doi]
AB  - The news media is frequently criticised for failing to support the goals of
      government health campaigns. But is this necessarily the purpose of the media? We
      suggest that while the media has an important role in disseminating health
      messages, it is a mistake to assume that the media should serve the interests of 
      government as it has its own professional ethics, norms, values, structures and
      roles that extend well beyond the interests of the health sector, and certainly
      beyond those of the government. While considerable attention has been given to
      the ways in which uncritical publication of industry perspectives by news media
      can negatively impact on public understandings of health and health behaviours,
      we would argue that it is equally important that journalists not become the
      'lapdogs' of government interests. Further, we suggest that the interests of
      public health may be served more by supporting the ongoing existence of an
      independent media than by seeking to overdetermine its purpose or scope.
FAU - Lipworth, Wendy
AU  - Lipworth W
AD  - University of New South Wales, Sydney, New South Wales 2052, Australia.
      w.lipworth@unsw.edu.au
FAU - Kerridge, Ian
AU  - Kerridge I
FAU - Morrell, Bronwen
AU  - Morrell B
FAU - Bonfiglioli, Catriona
AU  - Bonfiglioli C
FAU - Forsyth, Rowena
AU  - Forsyth R
LA  - eng
PT  - Journal Article
DEP - 20120922
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Australia
MH  - Government
MH  - Health Behavior
MH  - Health Education
MH  - Health Policy
MH  - Health Promotion
MH  - Humans
MH  - Information Dissemination/*ethics
MH  - *Journalism, Medical/standards
MH  - *Mass Media/ethics/standards/trends
MH  - *Newspapers as Topic/ethics/standards/trends
MH  - *Politics
MH  - *Public Health/ethics/standards/trends
MH  - Research Support as Topic/trends
MH  - Social Responsibility
MH  - United States
EDAT- 2012/09/25 06:00
MHDA- 2013/02/28 06:00
CRDT- 2012/09/25 06:00
PHST- 2012/09/25 06:00 [entrez]
PHST- 2012/09/25 06:00 [pubmed]
PHST- 2013/02/28 06:00 [medline]
AID - medethics-2012-100875 [pii]
AID - 10.1136/medethics-2012-100875 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Dec;38(12):768-70. doi: 10.1136/medethics-2012-100875. Epub
      2012 Sep 22.


PMID- 23001919
OWN - NLM
STAT- MEDLINE
DCOM- 20130304
LR  - 20211021
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 1
DP  - 2013 Jan
TI  - Ethical considerations in targeted paediatric neurosurgery missions.
PG  - 51-4
LID - 10.1136/medethics-2012-100610 [doi]
AB  - Within the context of global health development approaches, surgical missions to 
      provide care for underserved populations remain the least studied interventions
      with regard to their methodology. Because of the unique logistical needs of
      delivering operative care, surgical missions are often described solely in terms 
      of cases performed, with a paucity of discourse on medical ethics. Within
      surgery, subspecialties that serve patients on a non-elective basis should, it
      could be argued, create mission strategies that involve a didactic approach and
      the propagation of sustainable surgical care. The ethical considerations have yet
      to be described for paediatric neurosurgical outreach missions. We present here
      the perspectives of neurosurgeons who have participated in surgical outreach
      missions in Central America, South America, Eastern Europe and sub-Saharan Africa
      from the vantage point of both the visiting mission team and the host team that
      accommodates the mission efforts.
FAU - Hughes, Samuel A
AU  - Hughes SA
AD  - Department of Neurosurgery, Kaiser, Portland, OR, USA.
FAU - Jandial, Rahul
AU  - Jandial R
LA  - eng
GR  - K12 CA001727/CA/NCI NIH HHS/United States
PT  - Journal Article
DEP - 20120921
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Adolescent
MH  - Africa South of the Sahara
MH  - Central America
MH  - Child
MH  - Child, Preschool
MH  - Conflict of Interest
MH  - *Developed Countries
MH  - *Developing Countries
MH  - Europe, Eastern
MH  - Health Resources/ethics/statistics & numerical data
MH  - Humans
MH  - Informed Consent
MH  - Internet
MH  - Medical Missions/*ethics
MH  - Neurosurgery/*ethics
MH  - Neurosurgical Procedures/ethics
MH  - Pediatrics/*ethics
MH  - South America
MH  - Surgical Equipment
PMC - PMC3883460
MID - NIHMS529263
EDAT- 2012/09/25 06:00
MHDA- 2013/03/05 06:00
CRDT- 2012/09/25 06:00
PHST- 2012/09/25 06:00 [entrez]
PHST- 2012/09/25 06:00 [pubmed]
PHST- 2013/03/05 06:00 [medline]
AID - medethics-2012-100610 [pii]
AID - 10.1136/medethics-2012-100610 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Jan;39(1):51-4. doi: 10.1136/medethics-2012-100610. Epub 2012 
      Sep 21.


PMID- 23001457
OWN - NLM
STAT- MEDLINE
DCOM- 20131112
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 18
IP  - 3
DP  - 2012 Sep
TI  - Potential for bias in the context of neuroethics. Commentary on "Neuroscience,
      neuropolitics and neuroethics: the complex case of crime, deception and fMRI".
PG  - 593-600
LID - 10.1007/s11948-012-9399-y [doi]
AB  - Neuroscience research, like all science, is vulnerable to the influence of
      extraneous values in the practice of research, whether in research design or the 
      selection, analysis and interpretation of data. This is particularly problematic 
      for research into the biological mechanisms that underlie behavior, and
      especially the neurobiological underpinnings of moral development and ethical
      reasoning, decision-making and behavior, and the other elements of what is often 
      called the neuroscience of ethics. The problem arises because neuroscientists,
      like most everyone, bring to their work assumptions, preconceptions and values
      and other sources of potentially inappropriate bias of which they may be unaware.
      It is important that the training of neuroscientists, and research practice
      itself, include open and in-depth discussion and examination of the assumptions
      that underlie research. Further, policy makers, journalists, and the general
      public, that is, the consumers of neuroscience research findings (and by
      extension, neurotechnologies) should be made aware of the limitations as well as 
      the strengths of the science, the evolving nature of scientific understanding,
      and the often invisible values inherent in science.
FAU - Bird, Stephanie J
AU  - Bird SJ
AD  - sjbird@mit.edu
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20120922
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
CON - Sci Eng Ethics. 2012 Sep;18(3):573-91. PMID: 23054671
MH  - *Brain
MH  - *Crime
MH  - *Deception
MH  - Humans
MH  - Magnetic Resonance Imaging/*ethics
MH  - Neurosciences/*ethics
MH  - *Psychophysiology
MH  - *Social Justice
EDAT- 2012/09/25 06:00
MHDA- 2013/11/13 06:00
CRDT- 2012/09/25 06:00
PHST- 2012/08/16 00:00 [received]
PHST- 2012/08/20 00:00 [accepted]
PHST- 2012/09/25 06:00 [entrez]
PHST- 2012/09/25 06:00 [pubmed]
PHST- 2013/11/13 06:00 [medline]
AID - 10.1007/s11948-012-9399-y [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2012 Sep;18(3):593-600. doi: 10.1007/s11948-012-9399-y. Epub 2012
      Sep 22.


PMID- 23000028
OWN - NLM
STAT- MEDLINE
DCOM- 20130104
LR  - 20181202
IS  - 1879-0631 (Electronic)
IS  - 0024-3205 (Linking)
VI  - 91
IP  - 19-20
DP  - 2012 Nov 2
TI  - Neural progenitor cells derived from adult bone marrow mesenchymal stem cells
      promote neuronal regeneration.
PG  - 951-8
LID - 10.1016/j.lfs.2012.09.005 [doi]
LID - S0024-3205(12)00504-8 [pii]
AB  - AIM: It is well known that neural stem/progenitor cells (NS/PC) are an ideal cell
      type for the treatment of central nervous system (CNS) disease. However, ethical 
      problems have severely hampered fetal NS/PC from being widely used as a source
      for stem cell therapy. Recently, it has been demonstrated that autologous bone
      marrow mesenchymal stem cells (BMSC) can transdifferentiate into neural
      progenitor cells (NPC). The biological function of BMSC derived NPC (MDNPC) in
      neuronal systems remains unknown. In the present study, we aimed to investigate
      whether MDNPC can promote in vitro neural regeneration, a process comprising
      mainly the generation of neurons and neurotransmitters. MAIN METHODS: We
      co-cultured BMSC, MDNPC or fetal NS/PC with PC12 cells and studied their roles on
      proliferation, neurite formation and dopamine release from PC12 cells.
      Furthermore, we also explored the mechanisms by which MDNPC regulate dopamine
      secretion from PC12 derived neural cells using Western blot. KEY FINDINGS: We
      found that both MDNPC and NS/PC had similar morphologies and there were no
      significant differences between MDNPC and NS/PC in promoting PC12 cell
      proliferation, neurite outgrowth, and dopamine release. We also demonstrated that
      NS/PC induced dopamine secretion was associated with an upregulation of dopamine 
      transporter (DAT) levels. SIGNIFICANCE: In summary, MDNPC were comparable to
      NS/PC in promoting neural regeneration, indicating that MDNPC are a promising
      candidate source of neural stem cells for the treatment of neurological diseases.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Tang, Yue
AU  - Tang Y
AD  - State Key Laboratory of Translational Cardiovascular Medicine, Fuwai Hospital and
      Cardiovascular Institute, Chinese Academy of Medical Sciences, Peking Union
      Medical College, Beijing, China. tangyue1226@vip.sina.com
FAU - Cui, Yong-Chun
AU  - Cui YC
FAU - Wang, Xiao-Juan
AU  - Wang XJ
FAU - Wu, Ai-Li
AU  - Wu AL
FAU - Hu, Guang-Fu
AU  - Hu GF
FAU - Luo, Fu-Liang
AU  - Luo FL
FAU - Sun, Jia-Kang
AU  - Sun JK
FAU - Sun, Jing
AU  - Sun J
FAU - Wu, Li-Ke
AU  - Wu LK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120919
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Dopamine Plasma Membrane Transport Proteins)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Blotting, Far-Western
MH  - Bone Marrow Cells/*metabolism
MH  - Cell Proliferation
MH  - Dopamine/metabolism
MH  - Dopamine Plasma Membrane Transport Proteins/metabolism
MH  - Mesenchymal Stem Cells/*metabolism
MH  - *Nerve Regeneration
MH  - Neural Stem Cells/*metabolism
MH  - Neurites/metabolism
MH  - Neurons/*metabolism
MH  - PC12 Cells
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Up-Regulation
EDAT- 2012/09/25 06:00
MHDA- 2013/01/05 06:00
CRDT- 2012/09/25 06:00
PHST- 2012/03/16 00:00 [received]
PHST- 2012/08/18 00:00 [revised]
PHST- 2012/09/11 00:00 [accepted]
PHST- 2012/09/25 06:00 [entrez]
PHST- 2012/09/25 06:00 [pubmed]
PHST- 2013/01/05 06:00 [medline]
AID - S0024-3205(12)00504-8 [pii]
AID - 10.1016/j.lfs.2012.09.005 [doi]
PST - ppublish
SO  - Life Sci. 2012 Nov 2;91(19-20):951-8. doi: 10.1016/j.lfs.2012.09.005. Epub 2012
      Sep 19.


PMID- 22999396
OWN - NLM
STAT- MEDLINE
DCOM- 20131122
LR  - 20140205
IS  - 1806-907X (Electronic)
IS  - 0034-7094 (Linking)
VI  - 62
IP  - 5
DP  - 2012 Sep-Oct
TI  - Effects of preoperative sublingual misoprostol on uterine tone during isoflurane 
      anesthesia for cesarean section.
PG  - 625-35
LID - 10.1016/S0034-7094(12)70162-9 [doi]
LID - S0034-7094(12)70162-9 [pii]
AB  - BACKGROUND AND OBJECTIVES: Misoprostol would reduce the uterine bleeding after
      cesarean delivery without harmful effects on either mother or baby. We aimed to
      evaluate the effects of preoperative misoprostol on maternal blood loss, uterine 
      tone, and the need for additional oxytocin after cesarean delivery under
      isoflurane anesthesia. METHODS: After ethical approval, 366 patients scheduled
      for elective cesarean delivery were randomly allocated to receive either
      sublingual misoprostol 400mug (n=179) or placebo tablet (n=187) after intubation.
      Anesthesia was maintained with 0.5-0.7 MAC isoflurane with nitrous oxide. All
      patients received intravenous infusion of 10IU of oxytocin after placental
      delivery. Perioperative estimated blood loss, uterine tone, need for
      supplementary oxytocin, hematocrit, Apgar scores at 1 and 5 min and adverse
      effects were recorded. RESULTS: After induction, patients receiving sublingual
      misoprostol had significant less perioperative estimated blood loss (202+/-383.1 
      vs. 708+/-204.3mL, p<0.001), need for oxytocin (p<0.001), higher hematocrit
      levels (p<0.001) and uterine tone (p<0.02). The incidence of shivering was higher
      in the misoprostol group (p=0.04). There were no differences between the two
      groups as regarding Apgar scores, nausea and vomiting, gastrointestinal
      disturbances and pyrexia. CONCLUSION: Preoperative administration of sublingual
      misoprostol 400mug is safe and effective in attenuating the maternal bleeding and
      uterine atony from isoflurane anesthesia for cesarean delivery.
CI  - Copyright (c) 2012 Elsevier Editora Ltda. All rights reserved.
FAU - El Tahan, Mohamed R
AU  - El Tahan MR
AD  - Anesthesia and Surgical ICU, College of Medicine, Mansoura University, Egypt.
      mohamedrefaateltahan@yahoo.com
FAU - Warda, Osama M
AU  - Warda OM
FAU - Rashad, Amal
AU  - Rashad A
FAU - Yasseen, Amr M
AU  - Yasseen AM
FAU - Ramzy, Eiad A
AU  - Ramzy EA
FAU - Ahmady, Mona S
AU  - Ahmady MS
FAU - Diab, Douaa G
AU  - Diab DG
FAU - Matter, Mohamed K
AU  - Matter MK
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Brazil
TA  - Rev Bras Anestesiol
JT  - Revista brasileira de anestesiologia
JID - 0401316
RN  - 0 (Anesthetics, Inhalation)
RN  - 0 (Oxytocics)
RN  - 0E43V0BB57 (Misoprostol)
RN  - CYS9AKD70P (Isoflurane)
SB  - IM
MH  - Administration, Sublingual
MH  - Adolescent
MH  - Adult
MH  - *Anesthesia, Obstetrical
MH  - Anesthetics, Inhalation/*therapeutic use
MH  - *Cesarean Section
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Isoflurane/*therapeutic use
MH  - Misoprostol/*administration & dosage
MH  - Oxytocics/*administration & dosage
MH  - Pregnancy
MH  - Preoperative Care
MH  - Uterus/*drug effects
MH  - Young Adult
EDAT- 2012/09/25 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/09/25 06:00
PHST- 2011/11/10 00:00 [received]
PHST- 2011/12/05 00:00 [accepted]
PHST- 2012/09/25 06:00 [entrez]
PHST- 2012/09/25 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - S0034-7094(12)70162-9 [pii]
AID - 10.1016/S0034-7094(12)70162-9 [doi]
PST - ppublish
SO  - Rev Bras Anestesiol. 2012 Sep-Oct;62(5):625-35. doi:
      10.1016/S0034-7094(12)70162-9.


PMID- 22999166
OWN - NLM
STAT- MEDLINE
DCOM- 20130111
LR  - 20121112
IS  - 1523-6838 (Electronic)
IS  - 0272-6386 (Linking)
VI  - 60
IP  - 6
DP  - 2012 Dec
TI  - Pursuing permanent hemodialysis vascular access in patients with a poor
      prognosis: juxtaposing potential benefit and harm.
PG  - 1023-31
LID - 10.1053/j.ajkd.2012.07.020 [doi]
LID - S0272-6386(12)01140-7 [pii]
AB  - For patients with end-stage renal disease requiring hemodialysis, the native
      arteriovenous fistula remains the gold standard of vascular access, with tunneled
      cuffed central venous catheters reserved for temporary use or as a last resort in
      patients for whom a permanent vascular access is not possible. It is expected
      that most patients receiving hemodialysis will be suitable for arteriovenous
      fistula placement, with suitable patients defined as those: (1) for whom
      long-term dialysis is expected to confer benefit, (2) with vascular anatomy
      amenable to arteriovenous fistula placement, and (3) with progressive
      irreversible kidney failure who are more likely to require dialysis than to die
      before reaching dialysis dependence. The present article reviews considerations
      for vascular access decision making, focusing on older patients and those with a 
      poor prognosis, weighing the risks and benefits of arteriovenous fistulas,
      arteriovenous grafts, and central venous catheters and emphasizing that in the
      process of vascular access decision making for such patients, medical and ethical
      obligations to avoid central venous catheters must be balanced by the obligation 
      to do no harm.
CI  - Copyright (c) 2012 National Kidney Foundation, Inc. Published by Elsevier Inc.
      All rights reserved.
FAU - Schmidt, Rebecca J
AU  - Schmidt RJ
AD  - Section of Nephrology, West Virginia University School of Medicine, Morgantown,
      WV, USA. rschmidt@hsc.wvu.edu
FAU - Goldman, Richard S
AU  - Goldman RS
FAU - Germain, Michael
AU  - Germain M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20120919
PL  - United States
TA  - Am J Kidney Dis
JT  - American journal of kidney diseases : the official journal of the National Kidney
      Foundation
JID - 8110075
SB  - IM
MH  - Aged
MH  - Arteriovenous Shunt, Surgical/adverse effects/*methods
MH  - Catheterization, Central Venous/adverse effects/*methods
MH  - Female
MH  - Humans
MH  - Kidney Failure, Chronic/*diagnosis/etiology/*therapy
MH  - Prognosis
MH  - Renal Dialysis/*methods
EDAT- 2012/09/25 06:00
MHDA- 2013/01/12 06:00
CRDT- 2012/09/25 06:00
PHST- 2011/12/22 00:00 [received]
PHST- 2012/07/07 00:00 [accepted]
PHST- 2012/09/25 06:00 [entrez]
PHST- 2012/09/25 06:00 [pubmed]
PHST- 2013/01/12 06:00 [medline]
AID - S0272-6386(12)01140-7 [pii]
AID - 10.1053/j.ajkd.2012.07.020 [doi]
PST - ppublish
SO  - Am J Kidney Dis. 2012 Dec;60(6):1023-31. doi: 10.1053/j.ajkd.2012.07.020. Epub
      2012 Sep 19.


PMID- 22999017
OWN - NLM
STAT- MEDLINE
DCOM- 20130709
LR  - 20211021
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 13
DP  - 2012 Sep 22
TI  - A theoretical framework for early human studies: uncertainty, intervention
      ensembles, and boundaries.
PG  - 173
LID - 10.1186/1745-6215-13-173 [doi]
AB  - Clinical development of novel therapeutics begins with a coordinated sequence of 
      early phase clinical trials. Such early human studies confront a series of
      methodological and ethical challenges. In what follows, I propose a theoretical
      framework for early human studies aimed at informing the negotiation of these
      challenges. At the outset of clinical development, researchers confront a
      virtually undifferentiated landscape of uncertainty with respect to three
      variables: outcomes, their probability of occurrence, and operation dimensions
      needed to effectuate favorable outcomes. Early human trials transform this
      uncertain landscape into one where there are grounds for belief about risk and
      benefit for various combined operation dimensions. To accomplish this, studies
      set out with two aims. First, they identify a set of operation dimensions that,
      when combined as a package (intervention ensemble), elicits a reasonable
      probability of a target outcome. Second, they define the boundaries of dimension 
      values within an intervention ensemble. This latter aim entails exposing at least
      some volunteers in early studies to treatments that are inactive or excessive. I 
      provide examples that illustrate the way early human studies discover and delimit
      intervention ensembles, and close by offering some implications of this framework
      for ethics, methodology, and efficiency in clinical development of new
      interventions.
FAU - Kimmelman, Jonathan
AU  - Kimmelman J
AD  - Biomedical Ethics Unit/Experimental Medicine, McGill University, 3647 Peel
      Street, Montreal, QB H3A 1X1, Canada. jonathan.kimmelman@mcgill.ca
LA  - eng
GR  - EOG 102823/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120922
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
SB  - IM
MH  - Clinical Trials as Topic/classification/*methods
MH  - Drug-Related Side Effects and Adverse Reactions
MH  - Endpoint Determination
MH  - Humans
MH  - *Models, Theoretical
MH  - Patient Safety
MH  - Patient Selection
MH  - *Research Design
MH  - Risk Assessment
MH  - Terminology as Topic
MH  - Treatment Outcome
MH  - *Uncertainty
PMC - PMC3551836
EDAT- 2012/09/25 06:00
MHDA- 2013/07/10 06:00
CRDT- 2012/09/25 06:00
PHST- 2012/03/30 00:00 [received]
PHST- 2012/09/07 00:00 [accepted]
PHST- 2012/09/25 06:00 [entrez]
PHST- 2012/09/25 06:00 [pubmed]
PHST- 2013/07/10 06:00 [medline]
AID - 1745-6215-13-173 [pii]
AID - 10.1186/1745-6215-13-173 [doi]
PST - epublish
SO  - Trials. 2012 Sep 22;13:173. doi: 10.1186/1745-6215-13-173.


PMID- 22999004
OWN - NLM
STAT- MEDLINE
DCOM- 20130620
LR  - 20211021
IS  - 1471-2466 (Electronic)
IS  - 1471-2466 (Linking)
VI  - 12
DP  - 2012 Sep 21
TI  - Physiological relevance and performance of a minimal lung model: an experimental 
      study in healthy and acute respiratory distress syndrome model piglets.
PG  - 59
LID - 10.1186/1471-2466-12-59 [doi]
AB  - BACKGROUND: Mechanical ventilation (MV) is the primary form of support for acute 
      respiratory distress syndrome (ARDS) patients. However, intra- and inter-
      patient-variability reduce the efficacy of general protocols. Model-based
      approaches to guide MV can be patient-specific. A physiological relevant minimal 
      model and its patient-specific performance are tested to see if it meets this
      objective above. METHODS: Healthy anesthetized piglets weighing 24.0 kg [IQR:
      21.0-29.6] underwent a step-wise PEEP increase manoeuvre from 5cmH2O to 20cmH2O. 
      They were ventilated under volume control using Engstrom Care Station (Datex,
      General Electric, Finland), with pressure, flow and volume profiles recorded.
      ARDS was then induced using oleic acid. The data were analyzed with a Minimal
      Model that identifies patient-specific mean threshold opening and closing
      pressure (TOP and TCP), and standard deviation (SD) of these TOP and TCP
      distributions. The trial and use of data were approved by the Ethics Committee of
      the Medical Faculty of the University of Liege, Belgium. RESULTS AND DISCUSSIONS:
      3 of the 9 healthy piglets developed ARDS, and these data sets were included in
      this study. Model fitting error during inflation and deflation, in healthy or
      ARDS state is less than 5.0% across all subjects, indicating that the model
      captures the fundamental lung mechanics during PEEP increase. Mean TOP was
      42.4cmH2O [IQR: 38.2-44.6] at PEEP = 5cmH2O and decreased with PEEP to 25.0cmH2O 
      [IQR: 21.5-27.1] at PEEP = 20cmH2O. In contrast, TCP sees a reverse trend,
      increasing from 10.2cmH2O [IQR: 9.0-10.4] to 19.5cmH2O [IQR: 19.0-19.7]. Mean TOP
      increased from average 21.2-37.4cmH2O to 30.4-55.2cmH2O between healthy and ARDS 
      subjects, reflecting the higher pressure required to recruit collapsed alveoli.
      Mean TCP was effectively unchanged. CONCLUSION: The minimal model is capable of
      capturing physiologically relevant TOP, TCP and SD of both healthy and ARDS
      lungs. The model is able to track disease progression and the response to
      treatment.
FAU - Chiew, Yeong Shiong
AU  - Chiew YS
AD  - Department of Mechanical Engineering, University of Canterbury, Christchurch, New
      Zealand.
FAU - Chase, J Geoffrey
AU  - Chase JG
FAU - Lambermont, Bernard
AU  - Lambermont B
FAU - Janssen, Nathalie
AU  - Janssen N
FAU - Schranz, Christoph
AU  - Schranz C
FAU - Moeller, Knut
AU  - Moeller K
FAU - Shaw, Geoffrey M
AU  - Shaw GM
FAU - Desaive, Thomas
AU  - Desaive T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20120921
PL  - England
TA  - BMC Pulm Med
JT  - BMC pulmonary medicine
JID - 100968563
RN  - 2UMI9U37CP (Oleic Acid)
SB  - IM
MH  - Animals
MH  - *Disease Models, Animal
MH  - Disease Progression
MH  - Lung/*physiology/*physiopathology
MH  - Models, Biological
MH  - Oleic Acid/adverse effects
MH  - Positive-Pressure Respiration
MH  - Respiratory Distress Syndrome/chemically induced/*physiopathology
MH  - Respiratory Mechanics/physiology
MH  - Swine
PMC - PMC3511291
EDAT- 2012/09/25 06:00
MHDA- 2013/06/21 06:00
CRDT- 2012/09/25 06:00
PHST- 2012/06/26 00:00 [received]
PHST- 2012/09/19 00:00 [accepted]
PHST- 2012/09/25 06:00 [entrez]
PHST- 2012/09/25 06:00 [pubmed]
PHST- 2013/06/21 06:00 [medline]
AID - 1471-2466-12-59 [pii]
AID - 10.1186/1471-2466-12-59 [doi]
PST - epublish
SO  - BMC Pulm Med. 2012 Sep 21;12:59. doi: 10.1186/1471-2466-12-59.


PMID- 22998864
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20120924
IS  - 1097-4199 (Electronic)
IS  - 0896-6273 (Linking)
VI  - 75
IP  - 6
DP  - 2012 Sep 20
TI  - Implementing the 3Rs in neuroscience research: a reasoned approach.
PG  - 948-50
LID - 10.1016/j.neuron.2012.09.001 [doi]
LID - S0896-6273(12)00808-2 [pii]
AB  - The 3Rs--replacement, reduction, and refinement--are aimed at minimizing the
      welfare costs to animals used in research. Some neuroscientists fear that
      implementing the 3Rs will prohibit essential studies. Others view them as
      fundamental ethical principles that improve the quality of research. A regulatory
      system that integrates science and welfare is most likely to deliver public
      confidence.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Blakemore, Colin
AU  - Blakemore C
AD  - Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford OX1
      3PT, UK.
FAU - MaCarthur Clark, Judy
AU  - MaCarthur Clark J
FAU - Nevalainen, Timo
AU  - Nevalainen T
FAU - Oberdorfer, Michael
AU  - Oberdorfer M
FAU - Sussman, Arthur
AU  - Sussman A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
SB  - IM
MH  - *Animal Testing Alternatives
MH  - Animals
MH  - *Biomedical Research/ethics/methods
MH  - Humans
MH  - *Neurosciences/ethics
EDAT- 2012/09/25 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/09/25 06:00
PHST- 2012/09/25 06:00 [entrez]
PHST- 2012/09/25 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - S0896-6273(12)00808-2 [pii]
AID - 10.1016/j.neuron.2012.09.001 [doi]
PST - ppublish
SO  - Neuron. 2012 Sep 20;75(6):948-50. doi: 10.1016/j.neuron.2012.09.001.


PMID- 22998851
OWN - NLM
STAT- MEDLINE
DCOM- 20130515
LR  - 20130329
IS  - 1872-9142 (Electronic)
IS  - 0161-5890 (Linking)
VI  - 55
IP  - 1
DP  - 2013 Aug
TI  - Birds, babies and blood.
PG  - 35-47
LID - 10.1016/j.molimm.2012.08.023 [doi]
LID - S0161-5890(12)00382-3 [pii]
AB  - This is an autobiographical review describing the author's career in immunology
      research and summarizing his current understanding of the areas involved.
      Contributions to autoimmunity, immune deficiency, transfusion immunology,
      HLA-disease associations, reproductive immunology, cellular therapies, and innate
      immunity are included; also discussion of medical research ethics and various
      research-related activities.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Kilpatrick, David C
AU  - Kilpatrick DC
AD  - Scottish National Blood Transfusion Service, National Science Laboratory,
      Edinburgh, United Kingdom. alisonkilpatrick1@btinternet.com
LA  - eng
PT  - Autobiography
PT  - Biography
PT  - Historical Article
PT  - Journal Article
PT  - Review
DEP - 20120919
PL  - England
TA  - Mol Immunol
JT  - Molecular immunology
JID - 7905289
RN  - 0 (Lectins)
SB  - IM
MH  - Animals
MH  - Autoimmunity/immunology/physiology
MH  - Birds/physiology
MH  - *Blood Physiological Phenomena/immunology
MH  - Blood Transfusion
MH  - Female
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Infant, Newborn/blood/immunology/*physiology
MH  - Lectins/blood/metabolism/physiology
MH  - Lymphocytes/immunology/metabolism/physiology
MH  - Pregnancy/blood/immunology
MH  - Reproduction/*immunology/physiology
MH  - Transplantation Immunology
PS  - Kilpatrick DC
FPS - Kilpatrick, David C
EDAT- 2012/09/25 06:00
MHDA- 2013/05/17 06:00
CRDT- 2012/09/25 06:00
PHST- 2012/06/28 00:00 [received]
PHST- 2012/08/20 00:00 [revised]
PHST- 2012/08/22 00:00 [accepted]
PHST- 2012/09/25 06:00 [entrez]
PHST- 2012/09/25 06:00 [pubmed]
PHST- 2013/05/17 06:00 [medline]
AID - S0161-5890(12)00382-3 [pii]
AID - 10.1016/j.molimm.2012.08.023 [doi]
PST - ppublish
SO  - Mol Immunol. 2013 Aug;55(1):35-47. doi: 10.1016/j.molimm.2012.08.023. Epub 2012
      Sep 19.


PMID- 22998425
OWN - NLM
STAT- MEDLINE
DCOM- 20141222
LR  - 20161125
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 14
IP  - 1
DP  - 2014 Apr
TI  - Impact of three years training on operations capacities of research ethics
      committees in Nigeria.
PG  - 1-14
LID - 10.1111/j.1471-8847.2012.00340.x [doi]
AB  - This paper describes a three-year project designed to build the capacity of
      members of research ethics committes to perform their roles and responsibilities 
      efficiently and effectively. The project participants were made up of a
      cross-section of the membership of 13 Research Ethics Committees (RECs)
      functioning in Nigeria. They received training to develop their capacity to
      evaluate research protocols, monitor trial implementation, provide constructive
      input to trial staff, and assess the trial's success in promoting community
      engagement in the research. Following the training, technical assistance was
      provided to participants on an ongoing basis and the project's impacts were
      assessed quantitatively and qualitatively. Results indicate that sustained
      investment in capacity building efforts (including training, ongoing technical
      assistance, and the provision of multiple tools) improved the participants'
      knowledge of both the ethical principles relevant to biomedical research and how 
      effective REC should function. Such investment was also shown to have a positive 
      impact on the knowledge levels of other RECs members (those who did not receive
      training) and the overall operations of the RECs to which the participants
      belonged. Building the capacity of REC members to fulfill their roles effectively
      requires sustained effort and investment and pays off by enabling RECs to fulfill
      their essential mission of ensuring that trials are conducted safely and
      ethically.
CI  - (c) 2012 John Wiley & Sons Ltd.
FAU - Folayan, Morenike Oluwatoyin
AU  - Folayan MO
FAU - Adaranijo, Aisha
AU  - Adaranijo A
FAU - Durueke, Florita
AU  - Durueke F
FAU - Ajuwon, Ademola
AU  - Ajuwon A
FAU - Adejumo, Adebayo
AU  - Adejumo A
FAU - Ezechi, Oliver
AU  - Ezechi O
FAU - Oyedeji, Kola
AU  - Oyedeji K
FAU - Akanni, Olayide
AU  - Akanni O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120924
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
SB  - IM
MH  - Clinical Trials as Topic/ethics
MH  - *Community Participation
MH  - *Ethics Committees, Research
MH  - Ethics, Research/*education
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Needs Assessment
MH  - Nigeria
MH  - Program Evaluation
MH  - Qualitative Research
MH  - *Research Design
MH  - Surveys and Questionnaires
OTO - NOTNLM
OT  - bioethics
OT  - committees
OT  - developing world
OT  - research ethics
OT  - sub-Saharan Africa
EDAT- 2012/09/25 06:00
MHDA- 2014/12/23 06:00
CRDT- 2012/09/25 06:00
PHST- 2012/09/25 06:00 [entrez]
PHST- 2012/09/25 06:00 [pubmed]
PHST- 2014/12/23 06:00 [medline]
AID - 10.1111/j.1471-8847.2012.00340.x [doi]
PST - ppublish
SO  - Dev World Bioeth. 2014 Apr;14(1):1-14. doi: 10.1111/j.1471-8847.2012.00340.x.
      Epub 2012 Sep 24.


PMID- 22998399
OWN - NLM
STAT- MEDLINE
DCOM- 20130903
LR  - 20220410
IS  - 1471-2369 (Electronic)
IS  - 1471-2369 (Linking)
VI  - 13
DP  - 2012 Sep 24
TI  - Geriatric urolithiasis in the emergency department: risk factors for
      hospitalisation and emergency management patterns of acute urolithiasis.
PG  - 117
LID - 10.1186/1471-2369-13-117 [doi]
AB  - BACKGROUND: Urolithiasis is one of the most common conditions seen in emergency
      departments (ED) worldwide, with an increasing frequency in geriatric patients
      (>65 years). Given the high costs of emergency medical urolithiasis treatment,
      the need to optimise management is obvious. We aimed to determine risk factors
      for hospitalisation and evaluate diagnostic and emergency treatment patterns by
      ED physicians in geriatric urolithiasis patients to assist in optimising
      treatment. METHODS: After receiving ethics committee approval, we examined the
      records of emergency urolithiasis admissions to our ED between January 2000 and
      December 2010 to determine risk factors for hospitalisation and to evaluate
      current diagnostic and emergency treatment patterns in geriatric urolithiasis
      patients. RESULTS: 1,267 consecutive patients at least 20 years of age with
      confirmed urolithiasis (1,361 ED visits) and complete follow-up data were
      analyzed. Geriatric patients comprised 10% of urolithiasis patients with more
      than half of them experiencing their first urolithiasis episode at ED admission. 
      Although stone site, side and size did not significantly differ between groups,
      urinary stone disease was more severe in the elderly. The risk of severe
      complications correlated with increasing age, female sex and diabetes mellitus.
      Geriatric patients had a two-fold greater likelihood of being hospitalised. A
      significantly lower percentage of geriatric patients received combined analgesic 
      therapy for pain management (37% vs. 64%, p = <0.001) and supportive expulsive
      treatment (9% vs. 24%, p = <0.001). CONCLUSION: Geriatric patients with
      urolithiasis have a higher morbidity than younger patients and may be
      undertreated concerning analgetic and expulsive treatment in ED.
FAU - Arampatzis, Spyridon
AU  - Arampatzis S
AD  - Department of Nephrology and Hypertension, Inselspital, University of Bern, Bern,
      Switzerland. spyridon.arampatzis@insel.ch
FAU - Lindner, Gregor
AU  - Lindner G
FAU - Irmak, Filiz
AU  - Irmak F
FAU - Funk, Georg-Christian
AU  - Funk GC
FAU - Zimmermann, Heinz
AU  - Zimmermann H
FAU - Exadaktylos, Aristomenis K
AU  - Exadaktylos AK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120924
PL  - England
TA  - BMC Nephrol
JT  - BMC nephrology
JID - 100967793
SB  - IM
CIN - J Urol. 2013 Aug;190(2):573. PMID: 23845346
MH  - Acute Disease
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Disease Management
MH  - *Emergency Service, Hospital/trends
MH  - Female
MH  - Follow-Up Studies
MH  - *Hospitalization/trends
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Urolithiasis/diagnosis/*epidemiology/*therapy
MH  - Young Adult
PMC - PMC3511225
EDAT- 2012/09/25 06:00
MHDA- 2013/09/04 06:00
CRDT- 2012/09/25 06:00
PHST- 2012/01/30 00:00 [received]
PHST- 2012/09/19 00:00 [accepted]
PHST- 2012/09/25 06:00 [entrez]
PHST- 2012/09/25 06:00 [pubmed]
PHST- 2013/09/04 06:00 [medline]
AID - 1471-2369-13-117 [pii]
AID - 10.1186/1471-2369-13-117 [doi]
PST - epublish
SO  - BMC Nephrol. 2012 Sep 24;13:117. doi: 10.1186/1471-2369-13-117.


PMID- 22998395
OWN - NLM
STAT- MEDLINE
DCOM- 20141006
LR  - 20131114
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 13
IP  - 3
DP  - 2013 Dec
TI  - 'It looks like you just want them when things get rough': civil society
      perspectives on negative trial results and stakeholder engagement in HIV
      prevention trials.
PG  - 138-48
LID - 10.1111/j.1471-8847.2012.00338.x [doi]
AB  - Civil society organizations (CSOs) have significantly impacted on the politics of
      health research and the field of bioethics. In the global HIV epidemic, CSOs have
      served a pivotal stakeholder role. The dire need for development of new
      prevention technologies has raised critical challenges for the ethical engagement
      of community stakeholders in HIV research. This study explored the perspectives
      of CSO representatives involved in HIV prevention trials (HPTs) on the impact of 
      premature trial closures on stakeholder engagement. Fourteen respondents from
      South African and international CSOs representing activist and advocacy groups,
      community mobilisation initiatives, and human and legal rights groups were
      purposively sampled based on involvement in HPTs. Interviews were conducted from 
      February-May 2010. Descriptive analysis was undertaken across interviews and key 
      themes were developed inductively. CSO representatives largely described positive
      outcomes of recent microbicide and HIV vaccine trial terminations, particularly
      in South Africa, which they attributed to improvements in stakeholder engagement.
      Ongoing challenges to community engagement included the need for principled
      justifications for selective stakeholder engagement at strategic time-points, as 
      well as the need for legitimate alternatives to CABs as mechanisms for
      engagement. Key issues for CSOs in relation to research were also raised.
CI  - (c) 2012 John Wiley & Sons Ltd.
FAU - Koen, Jennifer
AU  - Koen J
FAU - Essack, Zaynab
AU  - Essack Z
FAU - Slack, Catherine
AU  - Slack C
FAU - Lindegger, Graham
AU  - Lindegger G
FAU - Newman, Peter A
AU  - Newman PA
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120924
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
SB  - IM
MH  - *Clinical Trials as Topic/ethics/standards/trends
MH  - *Community-Based Participatory Research/ethics/standards/trends
MH  - HIV Infections/*prevention & control
MH  - Humans
MH  - International Cooperation
MH  - Mass Media
MH  - *Social Responsibility
MH  - South Africa
OTO - NOTNLM
OT  - HIV/AIDS
OT  - NGO
OT  - South Africa
OT  - clinical trials
OT  - community network
OT  - developing world bioethics
EDAT- 2012/09/25 06:00
MHDA- 2014/10/07 06:00
CRDT- 2012/09/25 06:00
PHST- 2012/09/25 06:00 [entrez]
PHST- 2012/09/25 06:00 [pubmed]
PHST- 2014/10/07 06:00 [medline]
AID - 10.1111/j.1471-8847.2012.00338.x [doi]
PST - ppublish
SO  - Dev World Bioeth. 2013 Dec;13(3):138-48. doi: 10.1111/j.1471-8847.2012.00338.x.
      Epub 2012 Sep 24.


PMID- 22998095
OWN - NLM
STAT- MEDLINE
DCOM- 20121121
LR  - 20121011
IS  - 0098-9134 (Print)
IS  - 0098-9134 (Linking)
VI  - 38
IP  - 10
DP  - 2012 Oct
TI  - The use of socially assistive robots for dementia care.
PG  - 15-9
LID - 10.3928/00989134-20120911-02 [doi]
AB  - Innovative solutions for dementia care are required to address the steady rise in
      adults living with dementia, lack of adequate staffing to provide high-quality
      dementia care, and the need for family caregivers to provide care for their loved
      ones in the home. This article provides an overview of the use of socially
      assistive robots (SARs) to offer support as therapists, companions, and educators
      for people living with dementia. Social, ethical, and legal challenges associated
      with the use of robotic technology in patient care and implications for the use
      of SARs by nurses are discussed. These items considered, the authors conclude
      that SARs should be considered as a viable way to assist people living with
      dementia to maintain their highest possible level of independence, enhance their 
      quality of life, and provide support to overburdened family caregivers. Further
      research is needed to evaluate the merits of this technological approach in the
      care of adults with dementia.
CI  - Copyright 2012, SLACK Incorporated.
FAU - Huschilt, Julie
AU  - Huschilt J
AD  - Fleming College, Petersborough, Ontario, Canada. jhuschil@flemingc.on.ca
FAU - Clune, Laurie
AU  - Clune L
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120917
PL  - United States
TA  - J Gerontol Nurs
JT  - Journal of gerontological nursing
JID - 7510258
MH  - Dementia/*nursing
MH  - Ethics
MH  - Humans
MH  - *Robotics
EDAT- 2012/09/25 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/09/25 06:00
PHST- 2012/09/25 06:00 [entrez]
PHST- 2012/09/25 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.3928/00989134-20120911-02 [doi]
PST - ppublish
SO  - J Gerontol Nurs. 2012 Oct;38(10):15-9. doi: 10.3928/00989134-20120911-02. Epub
      2012 Sep 17.


PMID- 22998026
OWN - NLM
STAT- MEDLINE
DCOM- 20140121
LR  - 20130712
IS  - 1471-6712 (Electronic)
IS  - 0283-9318 (Linking)
VI  - 27
IP  - 3
DP  - 2013 Sep
TI  - Women's experiences of important others in a pregnancy dominated by intimate
      partner violence.
PG  - 643-50
LID - 10.1111/j.1471-6712.2012.01073.x [doi]
AB  - BACKGROUND: Being exposed to intimate partner violence (IPV) during pregnancy is 
      a difficult and complex situation. Despite this, there are few studies describing
      women's own needs for help and support. AIM: The aim of this study is to gain a
      deeper understanding of women's experiences of important others in relation to
      changing their life situation in a pregnancy dominated by IPV. METHODS: The study
      has a qualitative phenomenological design. The data were collected through
      in-depth interviews with seven Norwegian women, who were exposed to IPV during
      pregnancy. FINDINGS: Being pregnant and exposed to violence in relation to
      important others means confronting present life, life history and future life.
      The essence implies striving for control in an uncontrolled situation, where
      other people might be experienced as both a rescuer and a risk. This is further
      described in four constitutions: the child needs protection; my mother is always 
      present for me; an exhausted run for help; and a reduced, but important social
      network. CONCLUSIONS AND IMPLICATIONS FOR PRACTICE: For women exposed to
      violence, pregnancy can offer an opportunity for change. Midwives play a unique
      role in relation to care and continuity in this phase of life, as they can
      support pregnant women, help to identify their needs, possibilities for action
      and advise them about appropriate services. Midwives can encourage and support
      women to find people whom they can trust and who can offer assistance. It is
      vital that midwives ask about the women's relationship to the baby and their
      social networks, especially the relationship with their mothers. Ethical
      considerations: During the whole study process, guidelines for research on
      violence against women were followed, to respect the integrity, security and
      confidentiality of the participants. The study is ethically approved.
CI  - (c) 2012 The Authors. Scandinavian Journal of Caring Sciences (c) 2012 Nordic
      College of Caring Science.
FAU - Engnes, Kristin
AU  - Engnes K
AD  - Centre for Women's, Family and Child Health, Faculty of Health Sciences,
      Vestfold, Norway. kristin.engnes@hive.no
FAU - Liden, Eva
AU  - Liden E
FAU - Lundgren, Ingela
AU  - Lundgren I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120923
PL  - Sweden
TA  - Scand J Caring Sci
JT  - Scandinavian journal of caring sciences
JID - 8804206
MH  - Adult
MH  - *Domestic Violence
MH  - Female
MH  - Humans
MH  - Pregnancy
MH  - *Sexual Partners
MH  - Women/*psychology
MH  - Young Adult
OTO - NOTNLM
OT  - Qualitative approach
OT  - care
OT  - change
OT  - intimate partner violence
OT  - midwife
OT  - phenomenology
OT  - pregnancy
OT  - support
EDAT- 2012/09/25 06:00
MHDA- 2014/01/22 06:00
CRDT- 2012/09/25 06:00
PHST- 2012/09/25 06:00 [entrez]
PHST- 2012/09/25 06:00 [pubmed]
PHST- 2014/01/22 06:00 [medline]
AID - 10.1111/j.1471-6712.2012.01073.x [doi]
PST - ppublish
SO  - Scand J Caring Sci. 2013 Sep;27(3):643-50. doi: 10.1111/j.1471-6712.2012.01073.x.
      Epub 2012 Sep 23.


PMID- 22997522
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120924
LR  - 20211021
IS  - 1687-9678 (Electronic)
VI  - 2012
DP  - 2012
TI  - Ethical implications in the use of embryonic and adult neural stem cells.
PG  - 470949
AB  - The advent and growth of technological advances have led to new routes of
      knowledge. Thereby, we currently face new challenges. We have just started to get
      a glimpse of the structural and functional role of neural stem cells in
      differentiation and migration processes, the origin of synaptic networks, and
      subsequent readjustments in specific circuits. A whole range of treatment
      possibilities originates from this knowledge that potentially can be used for
      different neurological diseases in humans. Although this is an encouraging
      scenario, it implies that the human brain is the object of such study, as well as
      its potential manipulation and transplantation. It is, therefore, pertinent that 
      ethical principles should be followed in such research to have proper balance
      between what can be done and what should be done, according to every specific
      context. Hence, it is wise to consider ethical implications in every research
      project, along with potential clinical applications, under the principle of
      causing no harm, following risk and benefit rules in decision making and with
      respect of the human condition as a priority.
FAU - Ramos-Zuniga, Rodrigo
AU  - Ramos-Zuniga R
AD  - Department of Neurosciences, CUCS, Universidad de Guadalajara, 44630 Guadalajara,
      JAL, Mexico.
FAU - Gonzalez-Perez, Oscar
AU  - Gonzalez-Perez O
FAU - Macias-Ornelas, Ana
AU  - Macias-Ornelas A
FAU - Capilla-Gonzalez, Vivian
AU  - Capilla-Gonzalez V
FAU - Quinones-Hinojosa, Alfredo
AU  - Quinones-Hinojosa A
LA  - eng
PT  - Journal Article
DEP - 20120910
PL  - United States
TA  - Stem Cells Int
JT  - Stem cells international
JID - 101535822
PMC - PMC3444931
EDAT- 2012/09/22 06:00
MHDA- 2012/09/22 06:01
CRDT- 2012/09/22 06:00
PHST- 2012/07/01 00:00 [received]
PHST- 2012/08/07 00:00 [accepted]
PHST- 2012/09/22 06:00 [entrez]
PHST- 2012/09/22 06:00 [pubmed]
PHST- 2012/09/22 06:01 [medline]
AID - 10.1155/2012/470949 [doi]
PST - ppublish
SO  - Stem Cells Int. 2012;2012:470949. doi: 10.1155/2012/470949. Epub 2012 Sep 10.


PMID- 22997341
OWN - NLM
STAT- MEDLINE
DCOM- 20130513
LR  - 20121210
IS  - 1555-905X (Electronic)
IS  - 1555-9041 (Linking)
VI  - 7
IP  - 12
DP  - 2012 Dec
TI  - The ethics of end-of-life care for patients with ESRD.
PG  - 2049-57
LID - 10.2215/CJN.03900412 [doi]
AB  - Patients with ESRD have extensive and unique palliative care needs, often for
      years before death. The vast majority of patients, however, dies in acute care
      facilities without accessing palliative care services. High mortality rates along
      with a substantial burden of physical, psychosocial, and spiritual symptoms and
      an increasing prevalence of decisions to withhold and stop dialysis all highlight
      the importance of integrating palliative care into the comprehensive management
      of ESRD patients. The focus of renal care would then extend to controlling
      symptoms, communicating prognosis, establishing goals of care, and determining
      end-of-life care preferences. Regretfully, training in palliative care for
      nephrology trainees is inadequate. This article will provide a conceptual
      framework for renal palliative care and describe opportunities for enhancing
      palliative care for ESRD patients, including improved chronic pain management and
      advance care planning and a new model for delivering high-quality palliative care
      that includes appropriate consultation with specialist palliative care.
FAU - Davison, Sara N
AU  - Davison SN
AD  - Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
      sara.davison@ualberta.ca
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120920
PL  - United States
TA  - Clin J Am Soc Nephrol
JT  - Clinical journal of the American Society of Nephrology : CJASN
JID - 101271570
SB  - IM
MH  - *Advance Care Planning
MH  - Humans
MH  - Kidney Failure, Chronic/*therapy
MH  - *Pain Management
MH  - Palliative Care/*ethics/standards
MH  - Patient Selection
MH  - Practice Guidelines as Topic
MH  - Terminal Care/*ethics/standards
EDAT- 2012/09/22 06:00
MHDA- 2013/05/15 06:00
CRDT- 2012/09/22 06:00
PHST- 2012/09/22 06:00 [entrez]
PHST- 2012/09/22 06:00 [pubmed]
PHST- 2013/05/15 06:00 [medline]
AID - CJN.03900412 [pii]
AID - 10.2215/CJN.03900412 [doi]
PST - ppublish
SO  - Clin J Am Soc Nephrol. 2012 Dec;7(12):2049-57. doi: 10.2215/CJN.03900412. Epub
      2012 Sep 20.


PMID- 22996895
OWN - NLM
STAT- MEDLINE
DCOM- 20130325
LR  - 20190907
IS  - 1678-4561 (Electronic)
IS  - 1413-8123 (Linking)
VI  - 17
IP  - 9
DP  - 2012 Sep
TI  - [Reflections on the management of deinstitutionalization process].
PG  - 2447-56
LID - S1413-81232012000900025 [pii]
AB  - This study addresses mental health and, based on a conceptual review, offers
      considerations on the management of deinstitutionalization processes regarding
      individuals interned in long-stay psychiatric institutions. Elements concerning
      asylum formation and logic are discussed, along with the mechanisms necessary for
      the effective change in paradigm and practices, with deinstitutionalization and
      psychosocial rehabilitation as the core issues. Reflections are offered regarding
      management actions committed to the psychosocial model, linking such actions to
      the application of the components of care and going beyond the articulation of
      the tools of mental health policy. Theoretical reflection offers suggestions
      referring to the qualification processes of mental health professionals,
      deinstitutionalization in the management of the Unified Health System and
      tripartite action with co-accountability in actions and financing. The final
      considerations recognize the bureaucratic obstacles in the public realm and
      propose facing these challenges as a management challenge, along with processes
      of change that can radically commit to the lives of people, thereby broadening
      the discussion to the ethical realm.
FAU - Lucena, Marcela Adriana da Silva
AU  - Lucena MA
AD  - Departamento de Medicina Social, Centro de Ciencias da Saude, Universidade
      Federal de Pernambuco, Avenida Prof. Moraes Rego, s/n. Cidade Universitaria,
      Centro de Ciencias da Saude, bloco D, 1 andar, 50670-420 Recife PE.
      marcelaslucena@gmail.com
FAU - Bezerra, Adriana Falangola Benjamin
AU  - Bezerra AF
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Reflexoes sobre a gestao de processos de desinstitucionalizacao.
PL  - Brazil
TA  - Cien Saude Colet
JT  - Ciencia & saude coletiva
JID - 9713483
SB  - IM
MH  - Brazil
MH  - Deinstitutionalization/*organization & administration
MH  - Humans
MH  - Mental Disorders/rehabilitation
EDAT- 2012/09/22 06:00
MHDA- 2013/03/26 06:00
CRDT- 2012/09/22 06:00
PHST- 2011/04/30 00:00 [received]
PHST- 2011/07/30 00:00 [accepted]
PHST- 2012/09/22 06:00 [entrez]
PHST- 2012/09/22 06:00 [pubmed]
PHST- 2013/03/26 06:00 [medline]
AID - S1413-81232012000900025 [pii]
AID - 10.1590/s1413-81232012000900025 [doi]
PST - ppublish
SO  - Cien Saude Colet. 2012 Sep;17(9):2447-56. doi: 10.1590/s1413-81232012000900025.


PMID- 22996748
OWN - NLM
STAT- MEDLINE
DCOM- 20130103
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 265
IP  - 2
DP  - 2012 Nov
TI  - Quantification of variability in breath-hold perfusion CT of hepatocellular
      carcinoma: a step toward clinical use.
PG  - 448-56
LID - 10.1148/radiol.12111232 [doi]
AB  - PURPOSE: To assess the variability of breath-hold perfusion computed tomography
      (CT) parameters and to investigate whether these measurements are affected by a
      commercial software upgrade in patients with hepatocellular carcinoma (HCC).
      MATERIALS AND METHODS: Written informed consent was obtained from all
      participants in this institutional ethics committee-approved study. Perfusion CT 
      examinations in HCC patients were prospectively analyzed by three readers. Two
      readers repeated their analysis after an interval of at least 4 weeks. Inter- and
      intraobserver agreement, as well as intersoftware agreement, were assessed with
      intraclass correlation coefficients (ICCs) and Bland-Altman limits of agreement
      (LoA), with adjustment for correlation between repeated measures. RESULTS:
      Ninety-three breath-hold perfusion CT examinations were included from 23 HCC
      patients. The ICC between readers was very high (>0.91) for blood flow (BF), high
      (>0.84) for blood volume (BV), and lower (>0.30 and >0.39) for mean transit time 
      (MTT) and permeability surface area product (PS), respectively, while ICC between
      readings was high (>0.80) for BF and BV, good (>0.75) for PS, and lower (>0.38)
      for MTT, irrespective of software version. By using the current software, the
      clinically relevant percentage of LoA between readers for BF were -33%; for BV,
      -39%; for MTT, 55%; and for PS, -93%. Between readings by the most expert reader,
      the clinically relevant LoA were -35% for BF,-43% for BV, 33% for MTT, and -79%
      for PS. BF, BV, and PS values were significantly higher and MTT values were
      significantly lower (P<.01) with the current software version relative to the
      previous version. CONCLUSION: With the current CT perfusion software, only
      decreases between scans of HCC lesions of more than 35% for BF and 43% for BV, or
      an increase of more than 55% for MTT, could be considered beyond the analysis
      variability. The perfusion parameters obtained with the current and previous
      software versions were not exchangeable. The results of this study are specific
      for breath-hold perfusion CT of HCC and may not apply to different acquisition
      protocols and tumors.
CI  - (c) RSNA, 2012
FAU - Petralia, Giuseppe
AU  - Petralia G
AD  - Department of Radiology and Division of Epidemiology and Biostatistics, European 
      Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy.
      giuseppe.petralia@ieo.it
FAU - Summers, Paul
AU  - Summers P
FAU - Viotti, Stefano
AU  - Viotti S
FAU - Montefrancesco, Roberta
AU  - Montefrancesco R
FAU - Raimondi, Sara
AU  - Raimondi S
FAU - Bellomi, Massimo
AU  - Bellomi M
LA  - eng
PT  - Journal Article
DEP - 20120920
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Breath Holding
MH  - Carcinoma, Hepatocellular/*diagnostic imaging
MH  - Female
MH  - Humans
MH  - Liver Neoplasms/*diagnostic imaging
MH  - Male
MH  - Middle Aged
MH  - Observer Variation
MH  - Perfusion Imaging/*methods
MH  - Radiographic Image Enhancement/*methods
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - *Software
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2012/09/22 06:00
MHDA- 2013/01/04 06:00
CRDT- 2012/09/22 06:00
PHST- 2012/09/22 06:00 [entrez]
PHST- 2012/09/22 06:00 [pubmed]
PHST- 2013/01/04 06:00 [medline]
AID - radiol.12111232 [pii]
AID - 10.1148/radiol.12111232 [doi]
PST - ppublish
SO  - Radiology. 2012 Nov;265(2):448-56. doi: 10.1148/radiol.12111232. Epub 2012 Sep
      20.


PMID- 22996747
OWN - NLM
STAT- MEDLINE
DCOM- 20130211
LR  - 20151119
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 265
IP  - 3
DP  - 2012 Dec
TI  - 19F MR imaging golden angle-based capsule tracking for intestinal transit and
      catheter tracking: initial in vivo experience.
PG  - 917-25
LID - 10.1148/radiol.12120297 [doi]
AB  - PURPOSE: To combine fluorine 19 ((19)F) magnetic resonance (MR) imaging and
      golden angle radial acquisition and to assess the feasibility of (19)F MR imaging
      golden angle-based tracking for catheter tracking applications and simultaneous
      three-dimensional (3D) intestinal tracking of ingested (19)F-labeled capsules in 
      vivo. MATERIALS AND METHODS: Approval from the local ethical committee and
      informed consent from the subject were obtained. In vitro studies were performed 
      to assess (19)F MR imaging golden angle-based tracking reliability with regard to
      temporal resolution and different tracking strategies (boundary condition-free
      tracking, composite image-based tracking, and model-based tracking). In vivo
      performance of the method was investigated in one healthy volunteer on 2 days. On
      study day 1, a duodenal catheter incorporating five (19)F-labeled capsules was
      administered nasally, and its 3D movement was tracked inside the stomach and
      esophagus. On study day 2, three (19)F-labeled capsules were swallowed, and
      intestinal movement was tracked. RESULTS: Simultaneous in vivo 3D tracking of
      multiple (19)F-labeled capsules was successfully performed without incorporation 
      of boundary conditions at a temporal resolution of 252 msec. Incorporation of
      boundary conditions with composite image-based tracking and model-based tracking 
      increased tracking reliability and enabled temporal resolution as high as 108
      msec. CONCLUSION: Use of (19)F MR imaging golden angle-based capsule tracking
      enables in vivo tracking of (19)F-labeled capsules and catheters at high temporal
      resolution. The presented method is applicable to physioanatomic studies of the
      gastrointestinal tract and shows potential for real-time tracking in
      interventional radiology.
CI  - (c) RSNA, 2012.
FAU - Hahn, Tobias
AU  - Hahn T
AD  - Institute for Biomedical Engineering, University and ETH Zurich, Zurich,
      Switzerland.
FAU - Kozerke, Sebastian
AU  - Kozerke S
FAU - Schwizer, Werner
AU  - Schwizer W
FAU - Fried, Michael
AU  - Fried M
FAU - Boesiger, Peter
AU  - Boesiger P
FAU - Steingoetter, Andreas
AU  - Steingoetter A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120920
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Capsules)
RN  - 0 (Coated Materials, Biocompatible)
RN  - 0 (Crown Ethers)
RN  - 0 (Fluorocarbons)
RN  - 0 (perfluoro-15-crown-5-ether)
RN  - CMC18T611K (hexafluorobenzene)
SB  - IM
MH  - Algorithms
MH  - *Capsules
MH  - *Catheterization
MH  - Coated Materials, Biocompatible
MH  - Crown Ethers
MH  - Feasibility Studies
MH  - Fluorocarbons
MH  - Gastrointestinal Motility/*physiology
MH  - Gastrointestinal Transit/*physiology
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Imaging, Three-Dimensional
MH  - Magnetic Resonance Imaging, Interventional/*methods
MH  - Reproducibility of Results
MH  - Signal-To-Noise Ratio
EDAT- 2012/09/22 06:00
MHDA- 2013/02/12 06:00
CRDT- 2012/09/22 06:00
PHST- 2012/09/22 06:00 [entrez]
PHST- 2012/09/22 06:00 [pubmed]
PHST- 2013/02/12 06:00 [medline]
AID - radiol.12120297 [pii]
AID - 10.1148/radiol.12120297 [doi]
PST - ppublish
SO  - Radiology. 2012 Dec;265(3):917-25. doi: 10.1148/radiol.12120297. Epub 2012 Sep
      20.


PMID- 22996127
OWN - NLM
STAT- MEDLINE
DCOM- 20130124
LR  - 20120921
IS  - 1873-233X (Electronic)
IS  - 0029-7844 (Linking)
VI  - 120
IP  - 4
DP  - 2012 Oct
TI  - Committee opinion no. 537: reprocessed single-use devices.
PG  - 974-6
AB  - The reprocessing and reuse of single-use instruments has become increasingly
      common. Although there are limited data on reprocessed single-use devices,
      existing studies have found a significant rate of physical defects, performance
      issues, or improper decontamination. There are currently no data in the medical
      literature of studies evaluating the cost-effectiveness of reprocessed single-use
      devices in gynecologic surgery. The use of a reprocessed single-use device
      provides no direct benefit to an individual patient or her physician. It is the
      operating surgeon's ethical responsibility to make a good faith effort to know
      whether reprocessed single-use devices are to be used, and to not use instruments
      if he or she has concerns about the quality or safety of the instrument(s).
      Studies on the safety, quality, and cost-effectiveness of reprocessed single-use 
      devices in gynecologic surgery are needed. Physicians should be informed whether 
      the instruments used in surgery are original or reprocessed, and adverse events
      should be reported to improve the safety information about reprocessed single-use
      devices.
CN  - Committee on Gynecologic Practice, The American College of Obstetricians and
      Gynecologists
LA  - eng
PT  - Consensus Development Conference
PT  - Journal Article
PL  - United States
TA  - Obstet Gynecol
JT  - Obstetrics and gynecology
JID - 0401101
SB  - IM
MH  - Cost-Benefit Analysis
MH  - *Equipment Reuse/economics/legislation & jurisprudence/standards
MH  - Equipment Safety
MH  - Female
MH  - Gynecologic Surgical Procedures/economics/ethics/*instrumentation/standards
MH  - Humans
MH  - Patient Safety
MH  - United States
EDAT- 2012/09/22 06:00
MHDA- 2013/01/25 06:00
CRDT- 2012/09/22 06:00
PHST- 2012/09/22 06:00 [entrez]
PHST- 2012/09/22 06:00 [pubmed]
PHST- 2013/01/25 06:00 [medline]
AID - 10.1097/AOG.0b013e3182723b3b [doi]
AID - 00006250-201210000-00043 [pii]
PST - ppublish
SO  - Obstet Gynecol. 2012 Oct;120(4):974-6. doi: 10.1097/AOG.0b013e3182723b3b.


PMID- 22995018
OWN - NLM
STAT- MEDLINE
DCOM- 20130311
LR  - 20181201
IS  - 1365-2753 (Electronic)
IS  - 1356-1294 (Linking)
VI  - 18
IP  - 5
DP  - 2012 Oct
TI  - Commentary on Gupta, Mona (2011): improved health or improved decision making?
      The ethical goals of EBM. Journal of Evaluation in Clinical Practice 17(5),
      957-963.
PG  - 1110
LID - 10.1111/j.1365-2753.2012.01927.x [doi]
FAU - Rothenberger, Lillian Geza
AU  - Rothenberger LG
AD  - University of Tuebingen, Tuebingen, Germany. geza.rothenberger@uni-tuebingen.de
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - England
TA  - J Eval Clin Pract
JT  - Journal of evaluation in clinical practice
JID - 9609066
SB  - IM
CON - J Eval Clin Pract. 2011 Oct;17(5):957-63. PMID: 21851511
CIN - J Eval Clin Pract. 2012 Oct;18(5):1111-2. PMID: 22995019
MH  - *Decision Making
MH  - *Ethics, Clinical
MH  - Evidence-Based Medicine/*ethics
MH  - Humans
MH  - Informed Consent/*ethics
MH  - *Patient Participation
EDAT- 2012/09/22 06:00
MHDA- 2013/03/12 06:00
CRDT- 2012/09/22 06:00
PHST- 2012/09/22 06:00 [entrez]
PHST- 2012/09/22 06:00 [pubmed]
PHST- 2013/03/12 06:00 [medline]
AID - 10.1111/j.1365-2753.2012.01927.x [doi]
PST - ppublish
SO  - J Eval Clin Pract. 2012 Oct;18(5):1110. doi: 10.1111/j.1365-2753.2012.01927.x.


PMID- 22995016
OWN - NLM
STAT- MEDLINE
DCOM- 20130311
LR  - 20120921
IS  - 1365-2753 (Electronic)
IS  - 1356-1294 (Linking)
VI  - 18
IP  - 5
DP  - 2012 Oct
TI  - The lived body as a medical topic: an argument for an ethically informed
      epistemology.
PG  - 1095-101
LID - 10.1111/j.1365-2753.2012.01925.x [doi]
FAU - Kirkengen, Anna Luise
AU  - Kirkengen AL
AD  - Department of Public Health and General Practice, Norwegian University of Science
      and Technology, Trondheim, Norway. anlui-k@online.no
FAU - Thornquist, Eline
AU  - Thornquist E
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - J Eval Clin Pract
JT  - Journal of evaluation in clinical practice
JID - 9609066
SB  - IM
MH  - Adult Survivors of Child Abuse/psychology
MH  - *Clinical Medicine
MH  - *Ethics, Clinical
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Middle Aged
MH  - Pain/etiology/psychology
MH  - Psychophysiologic Disorders/diagnosis/*etiology
MH  - Stress, Psychological/physiopathology
EDAT- 2012/09/22 06:00
MHDA- 2013/03/12 06:00
CRDT- 2012/09/22 06:00
PHST- 2012/09/22 06:00 [entrez]
PHST- 2012/09/22 06:00 [pubmed]
PHST- 2013/03/12 06:00 [medline]
AID - 10.1111/j.1365-2753.2012.01925.x [doi]
PST - ppublish
SO  - J Eval Clin Pract. 2012 Oct;18(5):1095-101. doi:
      10.1111/j.1365-2753.2012.01925.x.


PMID- 22995007
OWN - NLM
STAT- MEDLINE
DCOM- 20130311
LR  - 20120921
IS  - 1365-2753 (Electronic)
IS  - 1356-1294 (Linking)
VI  - 18
IP  - 5
DP  - 2012 Oct
TI  - Imperfection, practice and humility in clinical ethics.
PG  - 1051-6
LID - 10.1111/j.1365-2753.2012.01916.x [doi]
AB  - In this essay, I provide a description of the discipline of ethics using the
      philosophies of Aristotle and the American pragmatist John Dewey. Specifically, I
      argue that ethics is an active undertaking that is ambiguous and pluralistic. I
      then normatively prescribe the way in which clinical ethicists ought to approach 
      their work in medicine. Rather than endeavouring to become, or behaving as if
      they are, experts, clinical ethicists must be humble. They must practise ethics. 
      That is, they must admit ethics is the study and pursuit of the good life but
      that this study and pursuit occurs imperfectly in the face of problematic
      situations.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Garchar, Kim
AU  - Garchar K
AD  - Philosophy, Kent State University, North Canton, OH, USA. kgarchar@kent.edu
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Eval Clin Pract
JT  - Journal of evaluation in clinical practice
JID - 9609066
SB  - IM
MH  - Ethicists/*psychology
MH  - *Ethics, Medical
MH  - Humans
MH  - Philosophy
MH  - *Professional Competence
MH  - *Self Concept
EDAT- 2012/09/22 06:00
MHDA- 2013/03/12 06:00
CRDT- 2012/09/22 06:00
PHST- 2012/09/22 06:00 [entrez]
PHST- 2012/09/22 06:00 [pubmed]
PHST- 2013/03/12 06:00 [medline]
AID - 10.1111/j.1365-2753.2012.01916.x [doi]
PST - ppublish
SO  - J Eval Clin Pract. 2012 Oct;18(5):1051-6. doi: 10.1111/j.1365-2753.2012.01916.x.


PMID- 22995006
OWN - NLM
STAT- MEDLINE
DCOM- 20130311
LR  - 20120921
IS  - 1365-2753 (Electronic)
IS  - 1356-1294 (Linking)
VI  - 18
IP  - 5
DP  - 2012 Oct
TI  - Autonomy and reason: treatment choice in breast cancer.
PG  - 1045-50
LID - 10.1111/j.1365-2753.2012.01915.x [doi]
AB  - The practice of offering choice to those women with breast cancer for whom either
      breast conserving surgery or mastectomy would be equally beneficial has come to
      be seen as an important aspect of medical care. As well as improving satisfaction
      with treatment, this is seen as satisfying the ethical principle of respect for
      autonomy. A number of studies, however, show that women are not always
      comfortable with such choice, preferring to leave treatment decisions to their
      surgeons. A question then arises as to the extent that these women can be seen as
      autonomous or as exercising autonomy. This paper argues, however, that the
      understanding of autonomy which is applied in current approaches to breast cancer
      care does not adequately support the exercise of autonomy, and that the clinical 
      context of care means that women are not able to engage in the kind of reasoning 
      that might promote the exercise of autonomy. Where respect for autonomy is
      limited to informed consent and choice, there is a danger that women's interests 
      are overlooked in those aspects of their care where choice is not appropriate,
      with very real, long-term consequences for some women. Promoting the exercise of 
      autonomy, it is argued, needs to go beyond the conception of autonomy as rational
      individuals making their own decisions, and clinicians need to work with an
      understanding of autonomy as relational in order to better involve women in their
      care.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Twomey, Mary
AU  - Twomey M
AD  - Faculty of Health and Social Care, Open University, Milton Keynes, UK.
      m.twomey@open.ac.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Eval Clin Pract
JT  - Journal of evaluation in clinical practice
JID - 9609066
SB  - IM
MH  - Breast Neoplasms/*psychology/*surgery
MH  - *Choice Behavior
MH  - Female
MH  - Humans
MH  - Mastectomy, Radical
MH  - Mastectomy, Segmental
MH  - *Personal Autonomy
EDAT- 2012/09/22 06:00
MHDA- 2013/03/12 06:00
CRDT- 2012/09/22 06:00
PHST- 2012/09/22 06:00 [entrez]
PHST- 2012/09/22 06:00 [pubmed]
PHST- 2013/03/12 06:00 [medline]
AID - 10.1111/j.1365-2753.2012.01915.x [doi]
PST - ppublish
SO  - J Eval Clin Pract. 2012 Oct;18(5):1045-50. doi: 10.1111/j.1365-2753.2012.01915.x.


PMID- 22995004
OWN - NLM
STAT- MEDLINE
DCOM- 20130311
LR  - 20120921
IS  - 1365-2753 (Electronic)
IS  - 1356-1294 (Linking)
VI  - 18
IP  - 5
DP  - 2012 Oct
TI  - Ethics between curriculum and workplace.
PG  - 1036-7
LID - 10.1111/j.1365-2753.2012.01913.x [doi]
FAU - Calder, Gideon
AU  - Calder G
AD  - University of Wales, Newport, UK.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Eval Clin Pract
JT  - Journal of evaluation in clinical practice
JID - 9609066
SB  - IM
MH  - *Curriculum
MH  - *Education, Medical
MH  - Ethics, Medical/*education
MH  - Humans
MH  - Physician-Patient Relations/*ethics
MH  - Resilience, Psychological
MH  - *Workplace
EDAT- 2012/09/22 06:00
MHDA- 2013/03/12 06:00
CRDT- 2012/09/22 06:00
PHST- 2012/09/22 06:00 [entrez]
PHST- 2012/09/22 06:00 [pubmed]
PHST- 2013/03/12 06:00 [medline]
AID - 10.1111/j.1365-2753.2012.01913.x [doi]
PST - ppublish
SO  - J Eval Clin Pract. 2012 Oct;18(5):1036-7. doi: 10.1111/j.1365-2753.2012.01913.x.


PMID- 22995003
OWN - NLM
STAT- MEDLINE
DCOM- 20130311
LR  - 20140109
IS  - 1365-2753 (Electronic)
IS  - 1356-1294 (Linking)
VI  - 18
IP  - 5
DP  - 2012 Oct
TI  - Meaning and value in medical school curricula.
PG  - 1027-35
LID - 10.1111/j.1365-2753.2012.01912.x [doi]
AB  - RATIONALE, AIMS AND OBJECTIVES: Bioethics and professionalism are standard
      subjects in medical training programmes, and these curricula reflect particular
      representations of meaning and practice. It is important that these curricula
      cohere with the actual concerns of practicing clinicians so that students are
      prepared for real-world practice. We aimed to identify ethical and professional
      concerns that do not appear to be adequately addressed in standard curricula by
      comparing ethics curricula with themes that emerged from a qualitative study of
      medical practitioners. METHOD: Curriculum analysis: Thirty-two prominent ethics
      and professionalism curricula were identified through a database search and were 
      analysed thematically. Qualitative study: In-depth, semi-structured interviews
      were conducted with 20 medical practitioners. Participants were invited to
      reflect upon their perceptions of the ways in which values matter in their
      practices and their educational experiences. The themes emerging from the two
      studies were compared and contrasted. RESULTS: While representations of meaning
      and value in ethics and professionalism curricula overlap with the preoccupations
      of practicing clinicians, there are significant aspects of 'real-world' clinical 
      practice that are largely ignored. These fell into two broad domains: (1)
      'sociological' concerns about enculturation, bureaucracy, intra-professional
      relationships, and public perceptions of medicine; and (2) epistemic concerns
      about making good decisions, balancing different kinds of knowledge, and
      practising within the bounds of professional protocols. CONCLUSIONS: Our findings
      support the view that philosophy and sociology should be included in medical
      school and specialty training curricula. Curricula should be reframed to
      introduce students to habits of thought that recognize the need for critical
      reflection on the social processes in which they are embedded, and on the
      philosophical assumptions that underpin their practice.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Lipworth, Wendy
AU  - Lipworth W
AD  - University of Sydney, New South Wales, Australia. wendylipworth@gmail.com
FAU - Kerridge, Ian
AU  - Kerridge I
FAU - Little, Miles
AU  - Little M
FAU - Gordon, Jill
AU  - Gordon J
FAU - Markham, Pippa
AU  - Markham P
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Eval Clin Pract
JT  - Journal of evaluation in clinical practice
JID - 9609066
SB  - IM
CIN - J Eval Clin Pract. 2013 Dec;19(6):1084. PMID: 23600403
MH  - Adult
MH  - Aged
MH  - Attitude of Health Personnel
MH  - *Curriculum
MH  - Databases, Factual
MH  - Ethics, Medical/education
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - New South Wales
MH  - Philosophy, Medical
MH  - Physicians/psychology
MH  - Qualitative Research
MH  - *Schools, Medical
MH  - *Social Values
EDAT- 2012/09/22 06:00
MHDA- 2013/03/12 06:00
CRDT- 2012/09/22 06:00
PHST- 2012/09/22 06:00 [entrez]
PHST- 2012/09/22 06:00 [pubmed]
PHST- 2013/03/12 06:00 [medline]
AID - 10.1111/j.1365-2753.2012.01912.x [doi]
PST - ppublish
SO  - J Eval Clin Pract. 2012 Oct;18(5):1027-35. doi: 10.1111/j.1365-2753.2012.01912.x.


PMID- 22995002
OWN - NLM
STAT- MEDLINE
DCOM- 20130311
LR  - 20120921
IS  - 1365-2753 (Electronic)
IS  - 1356-1294 (Linking)
VI  - 18
IP  - 5
DP  - 2012 Oct
TI  - Values-based medicine and modest foundationalism.
PG  - 1020-6
LID - 10.1111/j.1365-2753.2012.01911.x [doi]
AB  - Philosophically, values refer to the basic commitments that justify judgements,
      beliefs and practices, both at the community and personal levels. The study of
      these kinds of values is axiology. We suggest that all people subscribe to three 
      foundational values - survival, security and flourishing - and that these
      foundational values are expressed by way of concepts, systems, principles and
      practices that may differ substantially from culture to culture. Values can stand
      on their own as foundational justifications for health care and medicine. Many
      ethical quandaries can be better understood, even though they may remain
      unsolved, by reference to the foundational values that people can agree upon.
      This version of values-based health care has strong claims to prior logical
      status as a justification for the whole enterprise of health care, and
      values-based medicine is a part of this larger domain.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Little, Miles
AU  - Little M
AD  - Faculty of Medicine, University of Sydney, Sydney, Australia.
      miles.little@sydney.edu.au
FAU - Lipworth, Wendy
AU  - Lipworth W
FAU - Gordon, Jill
AU  - Gordon J
FAU - Markham, Pippa
AU  - Markham P
FAU - Kerridge, Ian
AU  - Kerridge I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Eval Clin Pract
JT  - Journal of evaluation in clinical practice
JID - 9609066
SB  - IM
MH  - Biomedical Research
MH  - *Clinical Medicine
MH  - Education, Medical
MH  - Humans
MH  - Philosophy, Medical
MH  - *Social Values
EDAT- 2012/09/22 06:00
MHDA- 2013/03/12 06:00
CRDT- 2012/09/22 06:00
PHST- 2012/09/22 06:00 [entrez]
PHST- 2012/09/22 06:00 [pubmed]
PHST- 2013/03/12 06:00 [medline]
AID - 10.1111/j.1365-2753.2012.01911.x [doi]
PST - ppublish
SO  - J Eval Clin Pract. 2012 Oct;18(5):1020-6. doi: 10.1111/j.1365-2753.2012.01911.x.


PMID- 22994914
OWN - NLM
STAT- MEDLINE
DCOM- 20141006
LR  - 20220330
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 13
IP  - 3
DP  - 2013 Dec
TI  - Prevalence of scientific misconduct among a group of researchers in Nigeria.
PG  - 149-57
LID - 10.1111/j.1471-8847.2012.00339.x [doi]
AB  - BACKGROUND: There is a dearth of information on the prevalence of scientific
      misconduct from Nigeria. OBJECTIVES: This study aimed at determining the
      prevalence of scientific misconduct in a group of researchers in Nigeria. Factors
      associated with the prevalence were ascertained. METHOD: A descriptive study of
      researchers who attended a scientific conference in 2010 was conducted using the 
      adapted Scientific Misconduct Questionnaire-Revised (SMQ-R). RESULTS: Ninety-one 
      researchers (68.9%) admitted having committed at least one of the eight listed
      forms of scientific misconduct. Disagreement about authorship was the most common
      form of misconduct committed (36.4%) while plagiarism was the least (9.2%). About
      42% of researchers had committed falsification of data or plagiarism. Analysis of
      specific acts of misconduct showed that committing plagiarism was inversely
      associated with years in research (Fisher exact p-value = 0.02); falsifying data 
      was related to perceived low effectiveness of the institution's rules and
      procedures for reducing scientific misconduct (X(2) = 6.44, p-value = 0.01); and 
      succumbing to pressure from study sponsor to engage in unethical practice was
      related to sex of researcher (Fisher exact p-value = 0.02). CONCLUSIONS: The
      emergent data from this study is a cause for serious concern and calls for prompt
      intervention. The best response to reducing scientific misconduct will proceed
      from measures that contain both elements of prevention and enforcement. Training 
      on research ethics has to be integrated into the curriculum of undergraduate and 
      postgraduate students while provision should be made for in-service training of
      researchers. Penalties against acts of scientific misconduct should be enforced
      at institutional and national levels.
CI  - (c) 2012 John Wiley & Sons Ltd.
FAU - Okonta, Patrick
AU  - Okonta P
FAU - Rossouw, Theresa
AU  - Rossouw T
LA  - eng
GR  - R25 TW001599/TW/FIC NIH HHS/United States
GR  - 2R25TW0 1599-10/TW/FIC NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20120920
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
SB  - IM
MH  - Adult
MH  - Authorship
MH  - Coercion
MH  - *Ethics, Research/education
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nigeria
MH  - Plagiarism
MH  - Prevalence
MH  - Publishing
MH  - Research Personnel/*ethics/*psychology/statistics & numerical data
MH  - Research Support as Topic
MH  - *Scientific Misconduct/ethics/legislation & jurisprudence/statistics & numerical 
      data/trends
MH  - Self Report
MH  - Sex Factors
MH  - *Students, Medical/psychology/statistics & numerical data
MH  - Surveys and Questionnaires
MH  - Time Factors
PMC - PMC3530634
MID - NIHMS397059
OTO - NOTNLM
OT  - bioethics
OT  - clinical
OT  - developing world
OT  - developing world bioethics
OT  - research ethics
EDAT- 2012/09/22 06:00
MHDA- 2014/10/07 06:00
CRDT- 2012/09/22 06:00
PHST- 2012/09/22 06:00 [entrez]
PHST- 2012/09/22 06:00 [pubmed]
PHST- 2014/10/07 06:00 [medline]
AID - 10.1111/j.1471-8847.2012.00339.x [doi]
PST - ppublish
SO  - Dev World Bioeth. 2013 Dec;13(3):149-57. doi: 10.1111/j.1471-8847.2012.00339.x.
      Epub 2012 Sep 20.


PMID- 22994886
OWN - NLM
STAT- MEDLINE
DCOM- 20141006
LR  - 20131114
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 13
IP  - 3
DP  - 2013 Dec
TI  - Research integrity in greater China: surveying regulations, perceptions and
      knowledge of research integrity from a Hong Kong perspective.
PG  - 125-37
LID - 10.1111/j.1471-8847.2012.00337.x [doi]
AB  - In their 2010 article 'Research Integrity in China: Problems and Prospects', Zeng
      and Resnik challenge others to engage in empirical research on research integrity
      in China. Here we respond to that call in three ways: first, we provide updates
      to their analysis of regulations and allegations of scientific misconduct;
      second, we report on two surveys conducted in Hong Kong that provide empirical
      backing to describe ways in which problems and prospects that Zeng and Resnik
      identify are being explored; and third, we continue the discussion started by
      Zeng and Resnik, pointing to ways in which China's high-profile participation in 
      international academic research presents concerns about research integrity.
      According to our research, based upon searches of both English and Chinese
      language literature and policies, and two surveys conducted in Hong Kong,
      academic faculty and research post-graduate students in Hong Kong are aware of
      and have a positive attitude towards responsible conduct of research. Although
      Hong Kong is but one small part of China, we present this research as a response 
      to concerns Zeng and Resnik introduce and as a call for a continued conversation.
CI  - (c) 2012 John Wiley & Sons Ltd.
FAU - Jordan, Sara R
AU  - Jordan SR
FAU - Gray, Phillip W
AU  - Gray PW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120920
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
SB  - IM
MH  - *Attitude of Health Personnel
MH  - China
MH  - Data Collection
MH  - *Ethics, Research
MH  - Government Regulation
MH  - Health Knowledge, Attitudes, Practice
MH  - Hong Kong
MH  - Humans
MH  - Research Personnel/*ethics
MH  - *Scientific Misconduct/ethics
MH  - *Social Perception
MH  - *Social Responsibility
MH  - Students, Medical/statistics & numerical data
OTO - NOTNLM
OT  - China
OT  - Education
OT  - Ethics
OT  - Hong Kong
OT  - Research Integrity
OT  - Research Misconduct
OT  - Responsible Conduct of Research
EDAT- 2012/09/22 06:00
MHDA- 2014/10/07 06:00
CRDT- 2012/09/22 06:00
PHST- 2012/09/22 06:00 [entrez]
PHST- 2012/09/22 06:00 [pubmed]
PHST- 2014/10/07 06:00 [medline]
AID - 10.1111/j.1471-8847.2012.00337.x [doi]
PST - ppublish
SO  - Dev World Bioeth. 2013 Dec;13(3):125-37. doi: 10.1111/j.1471-8847.2012.00337.x.
      Epub 2012 Sep 20.


PMID- 22994866
OWN - NLM
STAT- MEDLINE
DCOM- 20141006
LR  - 20220318
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 13
IP  - 3
DP  - 2013 Dec
TI  - Ethics education in research involving human beings in undergraduate medicine
      curriculum in Brazil.
PG  - 163-8
LID - 10.1111/j.1471-8847.2012.00336.x [doi]
AB  - INTRODUCTION: The Brazilian national curriculum guidelines for undergraduate
      medicine courses inspired and influenced the groundwork for knowledge
      acquisition, skills development and the perception of ethical values in the
      context of professional conduct. OBJECTIVE: The evaluation of ethics education in
      research involving human beings in undergraduate medicine curriculum in Brazil,
      both in courses with active learning processes and in those with traditional
      lecture learning methodologies. METHODS: Curricula and teaching projects of 175
      Brazilian medical schools were analyzed using a retrospective historical and
      descriptive exploratory cohort study. Thirty one medical schools were excluded
      from the study because of incomplete information or a refusal to participate.
      Active research for information from institutional sites and documents was guided
      by terms based on 69 DeCS/MeSH descriptors. Curriculum information was correlated
      with educational models of learning such as active learning methodologies,
      tutorial discussions with integrated curriculum into core modules, and
      traditional lecture learning methodologies for large classes organized by
      disciplines and reviewed by occurrence frequency of ethical themes and average
      hourly load per semester. RESULTS: Ninety-five medical schools used traditional
      learning methodologies. The ten most frequent ethical themes were: 1--ethics in
      research (26); 2--ethical procedures and advanced technology (46);
      3--ethic-professional conduct (413). Over 80% of schools using active learning
      methodologies had between 50 and 100 hours of scheduled curriculum time devoted
      to ethical themes whereas more than 60% of traditional learning methodology
      schools devoted less than 50 hours in curriculum time to ethical themes.
      CONCLUSION: The data indicates that medical schools that employ more active
      learning methodologies provide more attention and time to ethical themes than
      schools with traditional discipline-based methodologies. Given the importance of 
      ethical issues in contemporary medical education, these findings are significant 
      for curriculum change and modification plans in the future of Brazilian medical
      education.
CI  - (c) 2012 John Wiley & Sons Ltd.
FAU - Novaes, Maria Rita Garbi
AU  - Novaes MR
FAU - Guilhem, Dirce
AU  - Guilhem D
FAU - Barragan, Elena
AU  - Barragan E
FAU - Mennin, Stewart
AU  - Mennin S
LA  - eng
PT  - Journal Article
DEP - 20120920
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
SB  - IM
MH  - Adult
MH  - Brazil
MH  - *Curriculum/standards/trends
MH  - *Education, Medical, Undergraduate/methods/standards/trends
MH  - Ethics, Medical/*education
MH  - Ethics, Research/*education
MH  - Female
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Learning
MH  - Male
MH  - Retrospective Studies
MH  - Schools, Medical/statistics & numerical data
MH  - Students, Medical
MH  - Teaching
OTO - NOTNLM
OT  - Brazil
OT  - education
OT  - medical ethics
OT  - patient protection
OT  - research ethics
EDAT- 2012/09/22 06:00
MHDA- 2014/10/07 06:00
CRDT- 2012/09/22 06:00
PHST- 2012/09/22 06:00 [entrez]
PHST- 2012/09/22 06:00 [pubmed]
PHST- 2014/10/07 06:00 [medline]
AID - 10.1111/j.1471-8847.2012.00336.x [doi]
PST - ppublish
SO  - Dev World Bioeth. 2013 Dec;13(3):163-8. doi: 10.1111/j.1471-8847.2012.00336.x.
      Epub 2012 Sep 20.


PMID- 22994561
OWN - NLM
STAT- MEDLINE
DCOM- 20150409
LR  - 20140818
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 28
IP  - 7
DP  - 2014 Sep
TI  - Ethical issues related to screening for preeclampsia.
PG  - 360-7
LID - 10.1111/j.1467-8519.2012.02005.x [doi]
AB  - The implementation of new methods of treating and preventing disease raises many 
      question of both technical and moral character. Currently, many studies focus on 
      developing a screening test for preeclampsia (PE), a disease complicating 2-8% of
      pregnancies, potentially causing severe consequences for pregnant women and their
      fetuses. The purpose is to develop a test that can identify pregnancies at high
      risk for developing PE sufficiently early in pregnancy to allow for prophylaxis. 
      However, the question of implementing a screening test for PE does not only
      involve an evaluation of technical feasibility and clinical efficacy, it also
      requires an analysis of how the test influences the conditions and choices for
      those tested. This study evaluates state-of-the-art techniques for preeclampsia
      screening in an ethical framework, pointing out the central areas of moral
      relevance within the context of such screening activity. Furthermore, we propose 
      ethical guidelines that a screening programme for PE should meet in order to
      become an uncontroversial addition to prenatal health care.
CI  - (c) 2012 John Wiley & Sons Ltd.
FAU - Jorgensen, Jennifer M
AU  - Jorgensen JM
FAU - Hedley, Paula L
AU  - Hedley PL
FAU - Gjerris, Mickey
AU  - Gjerris M
FAU - Christiansen, Michael
AU  - Christiansen M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120920
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Decision Making
MH  - Early Diagnosis
MH  - Female
MH  - Humans
MH  - Mass Screening/*ethics
MH  - *Morals
MH  - Pre-Eclampsia/*diagnosis
MH  - Pregnancy
MH  - Prenatal Diagnosis/*ethics/methods
OTO - NOTNLM
OT  - ethics
OT  - guidelines
OT  - preeclampsia
OT  - screening
EDAT- 2012/09/22 06:00
MHDA- 2015/04/10 06:00
CRDT- 2012/09/22 06:00
PHST- 2012/09/22 06:00 [entrez]
PHST- 2012/09/22 06:00 [pubmed]
PHST- 2015/04/10 06:00 [medline]
AID - 10.1111/j.1467-8519.2012.02005.x [doi]
PST - ppublish
SO  - Bioethics. 2014 Sep;28(7):360-7. doi: 10.1111/j.1467-8519.2012.02005.x. Epub 2012
      Sep 20.


PMID- 22994476
OWN - NLM
STAT- MEDLINE
DCOM- 20130220
LR  - 20120921
IS  - 1743-498X (Electronic)
IS  - 1743-4971 (Linking)
VI  - 9
IP  - 5
DP  - 2012 Oct
TI  - Medicine, law, ethics: teaching versus learning.
PG  - 338-42
LID - 10.1111/j.1743-498X.2012.00571.x [doi]
AB  - PURPOSE: Doctors' anxieties about the legal environment begin during medical
      school. The signals faculty members send to medical students contribute to this
      anxiety. A pilot study was conducted to examine signals sent by faculty members
      to students regarding the relationship of legal risk management and ethical
      patient care at one medical school. It was also intended to determine the
      agreement between the messages faculty staff believe they are transmitting and
      those that students think they are hearing from faculty mentors. METHODS: A
      survey with six multiple-choice questions was sent electronically to clinical
      faculty staff of one medical school to elicit the signals faculty members send
      students regarding the relationship of legal risk management and ethical patient 
      care. A complementary survey instrument was sent to all 240 third- and
      fourth-year students to elicit their perceptions of what they were being taught
      by their mentors about the legal environment. Responses were tabulated, analysed,
      and interpreted. RESULTS: Faculty staff and student responses to six questions
      regarding teaching and learning about the relationship of legal risk management
      and ethical patient care revealed, for four of the six questions, statistically
      significantly different perspectives between what faculty members thought they
      were teaching and what students thought they were learning. CONCLUSIONS: Medical 
      schools should be teaching patient-centered medicine, reconciling an awareness of
      the legal environment with the provision of ethically and clinically sound
      patient care. To improve performance, we must address the messages faculty
      members send students and reduce the disparity between perceived faculty teaching
      and claimed student learning in this context.
CI  - (c) Blackwell Publishing Ltd 2012.
FAU - Kapp, Marshall
AU  - Kapp M
AD  - Center for Innovative Collaboration in Medicine & Law, Florida State University, 
      Florida 32306-4300, USA. marshall.kapp@med.fsu.edu
FAU - Turner, Gregory
AU  - Turner G
FAU - Baker, Dennis
AU  - Baker D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Teach
JT  - The clinical teacher
JID - 101227511
SB  - IM
MH  - Ethics, Medical
MH  - Humans
MH  - *Learning
MH  - Legislation, Medical
MH  - *Medicine
MH  - Risk Management
MH  - Schools, Medical/ethics/legislation & jurisprudence/*organization &
      administration
MH  - *Teaching
EDAT- 2012/09/22 06:00
MHDA- 2013/02/21 06:00
CRDT- 2012/09/22 06:00
PHST- 2012/09/22 06:00 [entrez]
PHST- 2012/09/22 06:00 [pubmed]
PHST- 2013/02/21 06:00 [medline]
AID - 10.1111/j.1743-498X.2012.00571.x [doi]
PST - ppublish
SO  - Clin Teach. 2012 Oct;9(5):338-42. doi: 10.1111/j.1743-498X.2012.00571.x.


PMID- 22994417
OWN - NLM
STAT- MEDLINE
DCOM- 20130410
LR  - 20211021
IS  - 1553-2712 (Electronic)
IS  - 1069-6563 (Linking)
VI  - 19
IP  - 10
DP  - 2012 Oct
TI  - Unconsented HIV testing in cases of occupational exposure: ethics, law, and
      policy.
PG  - 1181-7
LID - 10.1111/j.1553-2712.2012.01453.x [doi]
AB  - Postexposure prophylaxis (PEP) has substantially reduced the risk of acquiring
      human immunodeficiency virus (HIV) after an occupational exposure; nevertheless, 
      exposure to HIV remains a concern for emergency department providers. According
      to published guidelines, PEP should be taken only when source patients are
      HIV-positive or have risk factors for HIV. Initiating PEP when source patients
      are uninfected puts exposed persons at risk from taking toxic drugs with no
      compensating benefit. Forgoing PEP if the source is infected results in increased
      risk of acquiring HIV. What should be done if source patients refuse HIV testing?
      Is it justifiable to test the blood of these patients over their autonomous
      objection? The authors review current law and policy and perform an ethical
      analysis to determine if laws permitting unconsented testing in cases of
      occupational exposure can be ethically justified.
CI  - (c) 2012 by the Society for Academic Emergency Medicine.
FAU - Cowan, Ethan
AU  - Cowan E
AD  - Department of Emergency Medicine, Department of Epidemiology & Population Health,
      Albert Einstein College of Medicine, Jacobi Medical Center, Bronx, NY, USA.
      ethan.cowan@nbhn.net
FAU - Macklin, Ruth
AU  - Macklin R
LA  - eng
GR  - K23 AI078755/AI/NIAID NIH HHS/United States
GR  - 5K23AI078755-04/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20120920
PL  - United States
TA  - Acad Emerg Med
JT  - Academic emergency medicine : official journal of the Society for Academic
      Emergency Medicine
JID - 9418450
SB  - IM
MH  - HIV/*isolation & purification
MH  - HIV Infections/*diagnosis
MH  - Humans
MH  - Informed Consent/ethics/*legislation & jurisprudence
MH  - Occupational Exposure/ethics/*legislation & jurisprudence
MH  - Post-Exposure Prophylaxis/ethics/*legislation & jurisprudence
PMC - PMC3473147
MID - NIHMS402780
EDAT- 2012/09/22 06:00
MHDA- 2013/04/11 06:00
CRDT- 2012/09/22 06:00
PHST- 2012/09/22 06:00 [entrez]
PHST- 2012/09/22 06:00 [pubmed]
PHST- 2013/04/11 06:00 [medline]
AID - 10.1111/j.1553-2712.2012.01453.x [doi]
PST - ppublish
SO  - Acad Emerg Med. 2012 Oct;19(10):1181-7. doi: 10.1111/j.1553-2712.2012.01453.x.
      Epub 2012 Sep 20.


PMID- 22994376
OWN - NLM
STAT- MEDLINE
DCOM- 20130426
LR  - 20121107
IS  - 1464-5351 (Electronic)
IS  - 1369-1058 (Linking)
VI  - 14 Suppl 1
DP  - 2012
TI  - Let's talk about sex: reflections on conversations about love and sexuality in
      Kumasi and Endwa, Ghana.
PG  - S15-26
LID - 10.1080/13691058.2012.723751 [doi]
AB  - This paper recounts and reflects on conversations about love and sexuality
      conducted with young people in Kumasi and Endwa, Ghana. It examines the settings 
      of these conversations - in a kinship-based household, secondary schools and
      Pentecostal churches - and explores young people's reticence to talk about such
      matters in the light of intergenerational respect. Analysing young people's
      strategies of silence and provocative speech, the paper shows that,
      paradoxically, schools and churches provide institutionalised spaces for young
      people's subversive outspokenness that contrasts with the ethical codex of
      decency as the expression of hierarchical relations.
FAU - Bochow, Astrid
AU  - Bochow A
AD  - Max Planck Institute for Social Anthropology, Halle/Saale, Germany.
      bochow@eth.mpg.de
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120920
PL  - England
TA  - Cult Health Sex
JT  - Culture, health & sexuality
JID - 100883416
SB  - IM
MH  - Adolescent
MH  - Adolescent Behavior/*psychology
MH  - *Attitude to Health
MH  - *Courtship
MH  - *Cultural Characteristics
MH  - Female
MH  - Ghana
MH  - Humans
MH  - Interpersonal Relations
MH  - *Love
MH  - Male
MH  - Peer Group
MH  - Sexual Behavior/*statistics & numerical data
MH  - Social Perception
MH  - Social Values
MH  - Students/statistics & numerical data
EDAT- 2012/09/22 06:00
MHDA- 2013/04/27 06:00
CRDT- 2012/09/22 06:00
PHST- 2012/09/22 06:00 [entrez]
PHST- 2012/09/22 06:00 [pubmed]
PHST- 2013/04/27 06:00 [medline]
AID - 10.1080/13691058.2012.723751 [doi]
PST - ppublish
SO  - Cult Health Sex. 2012;14 Suppl 1:S15-26. doi: 10.1080/13691058.2012.723751. Epub 
      2012 Sep 20.


PMID- 22994340
OWN - NLM
STAT- MEDLINE
DCOM- 20130308
LR  - 20141120
IS  - 1365-2222 (Electronic)
IS  - 0954-7894 (Linking)
VI  - 42
IP  - 10
DP  - 2012 Oct
TI  - H(1)-antihistamines and urticaria: how can we predict the best drug for our
      patient?
PG  - 1423-9
LID - 10.1111/j.1365-2222.2012.03957.x [doi]
AB  - Urticaria, and especially chronic spontaneous urticaria (CSU), is a difficult
      condition to treat. Consequently, clinicians need to use the best
      H(1)-antihistamines currently available and the pharmaceutical industries need to
      keep developing H(1)-antihistamines that are more effective than the ones we have
      today. To do this we need to be able to compare the clinical efficacy of both
      established and new drugs. Obviously, the ideal way to do this is to use
      head-to-head studies in CSU. However, such studies are extremely expensive and,
      in the case of novel molecules, have ethical and logistical problems.
      Consequently, we need to have predictive models. Although determination of Ki, an
      indicator of the in vitro potency of an H(1)-antihistamine, may help in the
      initial selection of candidate molecules, the large differences in volume of
      distribution and tissue accumulation in humans, precludes this from being a good 
      predictor of clinical efficacy in CSU. From the data reviewed in this article,
      especially the direct comparative data of desloratadine and levocetirizine in
      weal and flare studies and CSU, weal and flare response would appear to be the
      best indicator we have of effectiveness of H(1)-antihistamines in clinical
      practice. However, it must be pointed out that the conclusion is, essentially,
      based on detailed comparisons of two drugs in studies sponsored by pharmaceutical
      companies. Consequently, to confirm the conclusions of this review, a multicentre
      study independent from the influence of pharmaceutical companies should be
      commissioned to compare the speed of onset and effectiveness of desloratadine,
      fexofenadine and levocetirizine in chronic spontaneous urticaria and against
      histamine-induced weal and flare responses in the same patients so that we have a
      clear understanding of the predictive value of our models.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Church, M K
AU  - Church MK
AD  - Department of Dermatology and Allergy, Allergie Cenrtum Charite,
      Charite-Universitatsmedizin, Berlin, Germany. mkc@southampton.ac.uk
FAU - Maurer, M
AU  - Maurer M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Clin Exp Allergy
JT  - Clinical and experimental allergy : journal of the British Society for Allergy
      and Clinical Immunology
JID - 8906443
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Histamine H1 Antagonists, Non-Sedating)
RN  - 6U5EA9RT2O (levocetirizine)
RN  - 7AJO3BO7QN (Loratadine)
RN  - 7BA5G9Y06Q (Terfenadine)
RN  - 820484N8I3 (Histamine)
RN  - E6582LOH6V (fexofenadine)
RN  - FVF865388R (desloratadine)
RN  - YO7261ME24 (Cetirizine)
SB  - IM
MH  - Anti-Allergic Agents/pharmacokinetics/*therapeutic use
MH  - Cetirizine/pharmacokinetics/*therapeutic use
MH  - Histamine/pharmacology
MH  - Histamine H1 Antagonists, Non-Sedating/pharmacokinetics/*therapeutic use
MH  - Humans
MH  - Loratadine/*analogs & derivatives/pharmacokinetics/therapeutic use
MH  - Predictive Value of Tests
MH  - Skin Tests/methods
MH  - Terfenadine/*analogs & derivatives/pharmacokinetics/therapeutic use
MH  - Urticaria/*drug therapy
EDAT- 2012/09/22 06:00
MHDA- 2013/03/09 06:00
CRDT- 2012/09/22 06:00
PHST- 2012/09/22 06:00 [entrez]
PHST- 2012/09/22 06:00 [pubmed]
PHST- 2013/03/09 06:00 [medline]
AID - 10.1111/j.1365-2222.2012.03957.x [doi]
PST - ppublish
SO  - Clin Exp Allergy. 2012 Oct;42(10):1423-9. doi: 10.1111/j.1365-2222.2012.03957.x.


PMID- 22994177
OWN - NLM
STAT- MEDLINE
DCOM- 20130611
LR  - 20211021
IS  - 1541-0048 (Electronic)
IS  - 0090-0036 (Linking)
VI  - 103
IP  - 5
DP  - 2013 May
TI  - Expected ethical competencies of public health professionals and graduate
      curricula in accredited schools of public health in North America.
PG  - 938-42
LID - 10.2105/AJPH.2012.300680 [doi]
AB  - OBJECTIVES: We assessed expected ethics competencies of public health
      professionals in codes and competencies, reviewed ethics instruction at schools
      of public health, and recommended ways to bridge the gap between them. METHODS:
      We reviewed the code of ethics and 3 sets of competencies, separating
      ethics-related competencies into 3 domains: professional, research, and public
      health. We reviewed ethics course requirements in 2010-2011 on the Internet sites
      of 46 graduate schools of public health and categorized courses as required, not 
      required, or undetermined. RESULTS: Half of schools (n = 23) required an ethics
      course for graduation (master's or doctoral level), 21 did not, and 2 had no
      information. Sixteen of 23 required courses were 3-credit courses. Course content
      varied from 1 ethics topic to many topics addressing multiple ethics domains.
      CONCLUSIONS: Consistent ethics education and competency evaluation can be
      accomplished through a combination of a required course addressing the 3 domains,
      integration of ethics topics in other courses, and "booster" trainings. Enhancing
      ethics competence of public health professionals is important to address the
      ethical questions that arise in public health research, surveillance, practice,
      and policy.
FAU - Lee, Lisa M
AU  - Lee LM
AD  - Office of Surveillance, Epidemiology, and Laboratory Services, Centers for
      Disease Control and Prevention, Atlanta, GA, USA. Lisa.Lee@bioethics.gov
FAU - Wright, Brandy
AU  - Wright B
FAU - Semaan, Salaam
AU  - Semaan S
LA  - eng
PT  - Journal Article
DEP - 20120920
PL  - United States
TA  - Am J Public Health
JT  - American journal of public health
JID - 1254074
SB  - IM
MH  - Bioethics/*education
MH  - Curriculum
MH  - Education, Graduate/standards/statistics & numerical data
MH  - Education, Public Health Professional/*standards/statistics & numerical data
MH  - Humans
MH  - North America
MH  - Professional Competence/*standards
MH  - Public Health Practice/*ethics
MH  - Schools, Public Health/*standards/statistics & numerical data
PMC - PMC3698833
EDAT- 2012/09/22 06:00
MHDA- 2013/06/12 06:00
CRDT- 2012/09/22 06:00
PHST- 2012/09/22 06:00 [entrez]
PHST- 2012/09/22 06:00 [pubmed]
PHST- 2013/06/12 06:00 [medline]
AID - 10.2105/AJPH.2012.300680 [doi]
PST - ppublish
SO  - Am J Public Health. 2013 May;103(5):938-42. doi: 10.2105/AJPH.2012.300680. Epub
      2012 Sep 20.


PMID- 22994176
OWN - NLM
STAT- MEDLINE
DCOM- 20130104
LR  - 20220310
IS  - 1541-0048 (Electronic)
IS  - 0090-0036 (Linking)
VI  - 102
IP  - 11
DP  - 2012 Nov
TI  - Ethical concerns in tobacco control nonsmoker and "nonnicotine" hiring policies: 
      the implications of employment restrictions for tobacco control.
PG  - 2013-8
LID - 10.2105/AJPH.2012.300745 [doi]
AB  - Smoking has been restricted in workplaces for some time. A number of
      organizations with health promotion or tobacco control goals have taken the
      further step of implementing employment restrictions. These restrictions apply to
      smokers and, in some cases, to anyone testing positive on cotinine tests, which
      also capture users of nicotine-replacement therapy and those exposed to
      secondhand smoke. Such policies are defended as closely related to broader
      antismoking goals: first, only nonsmokers can be role models and advocates for
      tobacco control; second, nonsmoker and "nonnicotine" hiring policies help
      denormalize tobacco use, thus advancing a central aspect of tobacco control.
      However, these arguments are problematic: not only can hiring restrictions come
      into conflict with broader antismoking goals, but they also raise significant
      problems of their own.
FAU - Voigt, Kristin
AU  - Voigt K
AD  - Biomedical Ethics Unit, McGill University, 3647 Peel St, Montreal, QC, Canada H3A
      1X1. kristin.voigt@mcgill.ca
LA  - eng
GR  - HOA-80072/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120920
PL  - United States
TA  - Am J Public Health
JT  - American journal of public health
JID - 1254074
RN  - 0 (Tobacco Smoke Pollution)
RN  - K5161X06LL (Cotinine)
SB  - IM
MH  - Cotinine/blood
MH  - Employment/ethics
MH  - Humans
MH  - Personnel Selection/*ethics
MH  - *Smoke-Free Policy
MH  - *Smoking Prevention
MH  - Tobacco Smoke Pollution/prevention & control
MH  - Tobacco Use Cessation/*methods
MH  - United States
MH  - Workplace/standards
PMC - PMC3477983
EDAT- 2012/09/22 06:00
MHDA- 2013/01/05 06:00
CRDT- 2012/09/22 06:00
PHST- 2012/09/22 06:00 [entrez]
PHST- 2012/09/22 06:00 [pubmed]
PHST- 2013/01/05 06:00 [medline]
AID - 10.2105/AJPH.2012.300745 [doi]
PST - ppublish
SO  - Am J Public Health. 2012 Nov;102(11):2013-8. doi: 10.2105/AJPH.2012.300745. Epub 
      2012 Sep 20.


PMID- 22993220
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 265
IP  - 1
DP  - 2012 Oct
TI  - Pulmonary nodule size evaluation with chest tomosynthesis.
PG  - 273-82
AB  - PURPOSE: To evaluate intra- and interobserver variability, as well as agreement
      for nodule size measurements on chest tomosynthesis and computed tomographic (CT)
      images. MATERIALS AND METHODS: The Regional Ethical Review Board approved this
      study, and all participants gave written informed consent. Thirty-six segmented
      nodules in 20 patients were included in the study. Eight observers measured the
      left-to-right, inferior-to-superior, and longest nodule diameters on chest
      tomosynthesis and CT images. Intra- and interobserver repeatability, as well as
      agreement between measurements on chest tomosynthesis and CT images, were
      assessed as recommended by Bland and Altman. RESULTS: The difference between the 
      mean manual and the segmented diameter was -2.2 and -2.3 mm for left-to-right and
      -2.6 and -2.2 mm for the inferior-to-superior diameter for measurements on chest 
      tomosynthesis and CT images, respectively. Intraobserver 95% limits of agreement 
      (LOA) for the longest diameter ranged from a lower limit of -1.1 mm and an upper 
      limit of 1.0 mm to -1.8 and 1.8 mm for chest tomosynthesis and from -0.6 and 0.9 
      mm to -3.1 and 2.2 mm for axial CT. Interobserver 95% LOA ranged from -1.3 and
      1.5 mm to -2.0 and 2.1 mm for chest tomosynthesis and from -1.8 and 1.1 mm to
      -2.2 and 3.1 mm for axial CT. The 95% LOA concerning the mean of the observers'
      measurements of the longest diameter at chest tomosynthesis and axial CT were
      +/-2.1 mm (mean measurement error, 0 mm). For the different observers, the 95%
      LOA between the modalities ranged from -2.2 and 1.6 mm to -3.2 and 2.8 mm.
      CONCLUSION: Measurements on chest tomosynthesis and CT images are comparable,
      because there is no evident bias between the modalities and the repeatability is 
      similar. The LOA between measurements for the two modalities raise concern if
      measurements from chest tomosynthesis and CT were to be used interchangeably.
CI  - (c) RSNA, 2012.
FAU - Johnsson, Ase A
AU  - Johnsson AA
AD  - Department of Radiology, the Sahlgrenska Academy at University of Gothenburg, and
      Department of Radiology, Sahlgrenska University Hospital, Bruna Straket 11,
      SE-413 45 Gothenburg, Sweden. ase.johns-son@gregion.se
FAU - Fagman, Erika
AU  - Fagman E
FAU - Vikgren, Jenny
AU  - Vikgren J
FAU - Fisichella, Valeria A
AU  - Fisichella VA
FAU - Boijsen, Marianne
AU  - Boijsen M
FAU - Flinck, Agneta
AU  - Flinck A
FAU - Kheddache, Susanne
AU  - Kheddache S
FAU - Svalkvist, Angelica
AU  - Svalkvist A
FAU - Bath, Magnus
AU  - Bath M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/diagnostic imaging/secondary
MH  - Male
MH  - Middle Aged
MH  - Observer Variation
MH  - Radiographic Image Interpretation, Computer-Assisted
MH  - Radiography, Thoracic
MH  - Solitary Pulmonary Nodule/*diagnostic imaging/secondary
MH  - Statistics, Nonparametric
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2012/09/21 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/09/21 06:00
PHST- 2012/09/21 06:00 [entrez]
PHST- 2012/09/21 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 265/1/273 [pii]
AID - 10.1148/radiol.12111459 [doi]
PST - ppublish
SO  - Radiology. 2012 Oct;265(1):273-82. doi: 10.1148/radiol.12111459.


PMID- 22993172
OWN - NLM
STAT- MEDLINE
DCOM- 20140113
LR  - 20181202
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 8
DP  - 2013 Aug
TI  - Commentary on 'Honorary authorship epidemic in scholarly publications? How the
      current use of citation-based evaluative metrics make (pseudo)honorary authors
      from honest contributors of every multiauthor article.'.
PG  - 513
LID - 10.1136/medethics-2012-100940 [doi]
FAU - Anderson, Melissa S
AU  - Anderson MS
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20120919
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
CON - J Med Ethics. 2013 Aug;39(8):509-12. PMID: 22865926
CIN - J Med Ethics. 2013 Aug;39(8):515-6. PMID: 23038802
MH  - Authorship/*standards
MH  - *Bibliometrics
MH  - Humans
MH  - Publishing/*ethics
MH  - Research Personnel/*ethics
MH  - *Research Report
OTO - NOTNLM
OT  - Research Ethics
EDAT- 2012/09/21 06:00
MHDA- 2014/01/15 06:00
CRDT- 2012/09/21 06:00
PHST- 2012/09/21 06:00 [entrez]
PHST- 2012/09/21 06:00 [pubmed]
PHST- 2014/01/15 06:00 [medline]
AID - medethics-2012-100940 [pii]
AID - 10.1136/medethics-2012-100940 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Aug;39(8):513. doi: 10.1136/medethics-2012-100940. Epub 2012
      Sep 19.


PMID- 22992891
OWN - NLM
STAT- MEDLINE
DCOM- 20130621
LR  - 20211021
IS  - 1433-0563 (Electronic)
IS  - 0340-2592 (Linking)
VI  - 51
IP  - 12
DP  - 2012 Dec
TI  - [Highlights of the history of onanism].
PG  - 1741-5
LID - 10.1007/s00120-012-2994-3 [doi]
AB  - For many societies in the world onanism is taboo because of religious and medical
      ethics. From ancient times until the present day this type of body sensation is
      disclaimed by modern communities like a recurrent theme. After the discovery of
      the mechanism of fertilisation by the biologist Eduard van Beneden (1846-1910) in
      1875 the feminine clitoris was declared to be a dispensable organ. The clitoris
      was suspected of causing hysteria, epilepsy and other forms of insanity. In the
      eighteenth century masturbation performed by young men was classified as a
      consumptive disease that caused inevitable death. The following presentation
      gives an historical overview through the history of onanism that demonstrates the
      artistic, philosophical and medical point of view on the sexuality of men.
FAU - Hatzinger, M
AU  - Hatzinger M
AD  - Urologische Abteilung, Markuskrankenhaus Frankfurt, Wilhelm-Epstein-Strasse 4,
      60431 Frankfurt, Deutschland. martin.hatzinger@fdk.info
FAU - Berberich, H
AU  - Berberich H
FAU - Moll, F
AU  - Moll F
FAU - Schultheiss, D
AU  - Schultheiss D
LA  - ger
PT  - English Abstract
PT  - Historical Article
PT  - Journal Article
TT  - Hohepunkte aus der Geschichte der Onanie.
PL  - Germany
TA  - Urologe A
JT  - Der Urologe. Ausg. A
JID - 1304110
SB  - IM
MH  - *Coitus Interruptus
MH  - Contraception/*history
MH  - History, 17th Century
MH  - History, 18th Century
MH  - History, 19th Century
MH  - History, 20th Century
MH  - Humans
MH  - Urology/*history
EDAT- 2012/09/21 06:00
MHDA- 2013/06/25 06:00
CRDT- 2012/09/21 06:00
PHST- 2012/09/21 06:00 [entrez]
PHST- 2012/09/21 06:00 [pubmed]
PHST- 2013/06/25 06:00 [medline]
AID - 10.1007/s00120-012-2994-3 [doi]
PST - ppublish
SO  - Urologe A. 2012 Dec;51(12):1741-5. doi: 10.1007/s00120-012-2994-3.


PMID- 22992666
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20151119
IS  - 1532-6535 (Electronic)
IS  - 0009-9236 (Linking)
VI  - 92
IP  - 4
DP  - 2012 Oct
TI  - Without an adequate ethical infrastructure, the road to personalized medicine
      will be rocky at best.
PG  - 411-2
LID - 10.1038/clpt.2012.142 [doi]
AB  - Discovering the genetic variations that create profiles of risk and drive
      individual responses to drugs and vaccines has proven more difficult than many
      initially presupposed. Rhetoric about the prospect of personalized medicine has
      exceeded the ability to deliver on that vision. There also remain significant
      ethical and policy obstacles that may hinder the arrival of personalized
      medicine. The emergence of new prenatal genetic tests make the resolution of
      these ethical challenges imperative.
FAU - Caplan, A L
AU  - Caplan AL
AD  - Division of Medical Ethics, Langone Medical Center, New York University, New
      York, New York, USA. arthur.caplan@nyumc.org
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Clin Pharmacol Ther
JT  - Clinical pharmacology and therapeutics
JID - 0372741
SB  - IM
MH  - Genetic Testing/*ethics/trends
MH  - Genetic Variation/genetics
MH  - Humans
MH  - Precision Medicine/*ethics/trends
EDAT- 2012/09/21 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/09/21 06:00
PHST- 2012/09/21 06:00 [entrez]
PHST- 2012/09/21 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - clpt2012142 [pii]
AID - 10.1038/clpt.2012.142 [doi]
PST - ppublish
SO  - Clin Pharmacol Ther. 2012 Oct;92(4):411-2. doi: 10.1038/clpt.2012.142.


PMID- 22992552
OWN - NLM
STAT- MEDLINE
DCOM- 20130306
LR  - 20121005
IS  - 1473-6578 (Electronic)
IS  - 0951-7367 (Linking)
VI  - 25
IP  - 6
DP  - 2012 Nov
TI  - Recovery: conceptual and ethical aspects.
PG  - 497-502
LID - 10.1097/YCO.0b013e328359052f [doi]
AB  - PURPOSE OF REVIEW: To examine recent publications on implications of recovery for
      the provision of mental health services. RECENT FINDINGS: Predominantly, the
      concept of recovery, implications for professional mental health services, and
      the impact of peer workers on the provision of healthcare are discussed. SUMMARY:
      Recovery in the context of mental health issues refers to multiple dimensions of 
      the individual's development. According to recent publications, the dimension of 
      an individual journey, measurable through subjective parameters and accounts, is 
      complementary to the traditional objectives of symptom reduction, improvement of 
      functioning, and social inclusion. To foster recovery orientation in mental
      health services subjective measures should be included in clinical practice,
      research, and teaching. Moreover, services striving to support recovery need to
      implement strategies in terms of policy, concepts, structures, and professional
      attitude. This challenging paradigm shift is claimed to be supported by the
      integration of peer workers with own lived experience in the provision of mental 
      healthcare. Some exponents of the social recovery movement criticize this recent 
      international development to implement recovery into traditional services, as it 
      would uphold the established structures of power and control. Questions of
      impaired legal capacity, involuntary admissions and risk assessment related to
      recovery are rarely discussed.
FAU - Jaeger, Matthias
AU  - Jaeger M
AD  - Department of General and Social Psychiatry, Psychiatric University Hospital
      Zurich, Zurich, Switzerland. matthias.jaeger@puk.zh.ch
FAU - Hoff, Paul
AU  - Hoff P
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Psychiatry
JT  - Current opinion in psychiatry
JID - 8809880
SB  - IM
MH  - Health Services Needs and Demand
MH  - Humans
MH  - Mental Disorders/*rehabilitation
MH  - Mental Health Services
MH  - Peer Group
MH  - *Psychiatry/ethics/methods
MH  - Recovery of Function
EDAT- 2012/09/21 06:00
MHDA- 2013/03/07 06:00
CRDT- 2012/09/21 06:00
PHST- 2012/09/21 06:00 [entrez]
PHST- 2012/09/21 06:00 [pubmed]
PHST- 2013/03/07 06:00 [medline]
AID - 10.1097/YCO.0b013e328359052f [doi]
PST - ppublish
SO  - Curr Opin Psychiatry. 2012 Nov;25(6):497-502. doi: 10.1097/YCO.0b013e328359052f.


PMID- 22992409
OWN - NLM
STAT- MEDLINE
DCOM- 20130801
LR  - 20211021
IS  - 1471-2369 (Electronic)
IS  - 1471-2369 (Linking)
VI  - 13
DP  - 2012 Sep 19
TI  - Care of undocumented-uninsured immigrants in a large urban dialysis unit.
PG  - 112
LID - 10.1186/1471-2369-13-112 [doi]
AB  - BACKGROUND: Medical, ethical and financial dilemmas may arise in treating
      undocumented-uninsured patients with end-stage renal disease (ESRD). Hereby we
      describe the 10-year experience of treating undocumented-uninsured ESRD patients 
      in a large public dialysis-unit. METHODS: We evaluated the medical files of all
      the chronic dialysis patients treated at the Tel-Aviv Medical Center between the 
      years 2000-2010. Data for all immigrant patients without documentation and
      medical insurance were obtained. Clinical data were compared with an age-matched 
      cohort of 77 insured dialysis patients. RESULTS: Fifteen undocumented-uninsured
      patients were treated with chronic scheduled dialysis therapy for a mean length
      of 2.3 years and a total of 4953 hemodialysis sessions, despite lack of
      reimbursement. All undocumented-uninsured patients presented initially with
      symptoms attributed to uremia and with stage 5 chronic kidney disease (CKD). In
      comparison, in the age-matched cohort, only 6 patients (8%) were initially
      evaluated by a nephrologist at stage 5 CKD. Levels of hemoglobin (8.5 +/- 1.7
      versus 10.8 +/- 1.6 g/dL; p < 0.0001) and albumin (33.8 +/- 4.8 versus 37.7 +/-
      3.9 g/L; p < 0.001) were lower in the undocumented-uninsured dialysis patients
      compared with the age-matched insured patients at initiation of hemodialysis
      therapy. These significant changes were persistent throughout the treatment
      period. Hemodialysis was performed in all the undocumented-uninsured patients via
      tunneled cuffed catheters (TCC) without higher rates of TCC-associated
      infections. The rate of skipped hemodialysis sessions was similar in the
      undocumented-uninsured and age-matched insured cohorts. CONCLUSIONS:
      Undocumented-uninsured dialysis patients presented initially in the advanced
      stages of CKD with lower levels of hemoglobin and worse nutritional status in
      comparison with age-matched insured patients. The type of vascular access for
      hemodialysis was less than optimal with regards to current guidelines. There is a
      need for the national and international nephrology communities to establish a
      policy concerning the treatment of undocumented-uninsured patients with CKD.
FAU - Chernin, Gil
AU  - Chernin G
AD  - Nephrology Department, Tel-Aviv Sourasky Medical Center and Sackler Faculty of
      Medicine, Tel-Aviv University, Tel-Aviv, 64239, Israel. gilc@tasmc.health.gov.il
FAU - Gal-Oz, Amir
AU  - Gal-Oz A
FAU - Schwartz, Idit F
AU  - Schwartz IF
FAU - Shashar, Moshe
AU  - Shashar M
FAU - Schwartz, Doron
AU  - Schwartz D
FAU - Weinstein, Talia
AU  - Weinstein T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20120919
PL  - England
TA  - BMC Nephrol
JT  - BMC nephrology
JID - 100967793
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cohort Studies
MH  - Emigrants and Immigrants/*statistics & numerical data
MH  - Female
MH  - Health Services Accessibility/*statistics & numerical data
MH  - Humans
MH  - Israel/epidemiology
MH  - Male
MH  - Medically Uninsured/*statistics & numerical data
MH  - Middle Aged
MH  - Nephrology/statistics & numerical data
MH  - Prevalence
MH  - Renal Dialysis/*statistics & numerical data
MH  - Renal Insufficiency, Chronic/diagnosis/*epidemiology/*rehabilitation
MH  - Socioeconomic Factors
MH  - Urban Population/*statistics & numerical data
PMC - PMC3615959
EDAT- 2012/09/21 06:00
MHDA- 2013/08/02 06:00
CRDT- 2012/09/21 06:00
PHST- 2012/06/05 00:00 [received]
PHST- 2012/09/17 00:00 [accepted]
PHST- 2012/09/21 06:00 [entrez]
PHST- 2012/09/21 06:00 [pubmed]
PHST- 2013/08/02 06:00 [medline]
AID - 1471-2369-13-112 [pii]
AID - 10.1186/1471-2369-13-112 [doi]
PST - epublish
SO  - BMC Nephrol. 2012 Sep 19;13:112. doi: 10.1186/1471-2369-13-112.


PMID- 22992267
OWN - NLM
STAT- MEDLINE
DCOM- 20130523
LR  - 20211021
IS  - 1471-2407 (Electronic)
IS  - 1471-2407 (Linking)
VI  - 12
DP  - 2012 Sep 19
TI  - Eicosapentaenoic acid (EPA) efficacy for colorectal aberrant crypt foci (ACF): a 
      double-blind randomized controlled trial.
PG  - 413
LID - 10.1186/1471-2407-12-413 [doi]
AB  - BACKGROUND: Colorectal cancer (CRC) is one of the most commonly occurring
      neoplasms and a leading cause of cancer death worldwide, and new preventive
      strategies are needed to lower the burden of this disease. Eicosapentaenoic acid 
      (EPA), the omega-3 polyunsaturated fatty acid that is widely used in the
      treatment of hyperlipidemia and prevention of cardiovascular disease, has
      recently been suggested to have a suppressive effect on tumorigenesis and cancer 
      cell growth. In CRC chemoprevention trials, in general, the incidence of polyps
      or of the cancer itself is set as the study endpoint. Although the incidence rate
      of CRC would be the most reliable endpoint, use of this endpoint would be
      unsuitable for chemoprevention trials, because of the relatively low occurrence
      rate of CRC in the general population and the long-term observation period that
      it would necessitate. Moreover, there is an ethical problem in conducting
      long-term trials to determine whether a test drug might be effective or harmful. 
      Aberrant crypt foci (ACF), defined as lesions containing crypts that are larger
      in diameter and stain more darkly with methylene blue than normal crypts, are
      considered as a reliable surrogate biomarker of CRC. Thus, we devised a
      prospective randomized controlled trial as a preliminary study prior to a CRC
      chemoprevention trial to evaluate the chemopreventive effect of EPA against
      colorectal ACF formation and the safety of this drug, in patients scheduled for
      polypectomy. METHODS: This study is a multicenter, double-blind,
      placebo-controlled, randomized controlled trial to be conducted in patients with 
      both colorectal ACF and colorectal polyps scheduled for polypectomy. Eligible
      patients shall be recruited for the study and the number of ACF in the rectum
      counted at the baseline colonoscopy. Then, the participants shall be allocated
      randomly to either one of two groups, the EPA group and the placebo group.
      Patients in the EPA group shall receive oral 900-mg EPA capsules thrice daily
      (total daily dose, 2.7 g per day), and those in the placebo group shall receive
      oral placebo capsules thrice daily. After one month's treatment with EPA/placebo,
      colonoscopic examination and polypectomy will be performed to evaluate the
      formation of ACF, and the cell-proliferative activity and cell-apoptotic activity
      in normal colorectal mucosa and colorectal polyps. DISCUSSION: This is the first 
      study proposed to explore the effect of EPA against colorectal ACF formation in
      humans.This trial has been registered in the University hospital Medical
      Information Network (UMIN) Clinical Trials Registry as UMIN000008172.
FAU - Higurashi, Takuma
AU  - Higurashi T
AD  - Division of Gastroenterology, Yokohama City University School of Medicine, 3-9
      Fuku-ura, Kanazawa-ku, Yokohama 236-0004, Japan.
FAU - Hosono, Kunihiro
AU  - Hosono K
FAU - Endo, Hiroki
AU  - Endo H
FAU - Takahashi, Hirokazu
AU  - Takahashi H
FAU - Iida, Hiroshi
AU  - Iida H
FAU - Uchiyama, Takashi
AU  - Uchiyama T
FAU - Ezuka, Akiko
AU  - Ezuka A
FAU - Uchiyama, Shiori
AU  - Uchiyama S
FAU - Yamada, Eiji
AU  - Yamada E
FAU - Ohkubo, Hidenori
AU  - Ohkubo H
FAU - Sakai, Eiji
AU  - Sakai E
FAU - Maeda, Shin
AU  - Maeda S
FAU - Morita, Satoshi
AU  - Morita S
FAU - Natsumeda, Yutaka
AU  - Natsumeda Y
FAU - Nagase, Hajime
AU  - Nagase H
FAU - Nakajima, Atsushi
AU  - Nakajima A
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20120919
PL  - England
TA  - BMC Cancer
JT  - BMC cancer
JID - 100967800
RN  - AAN7QOV9EA (Eicosapentaenoic Acid)
SB  - IM
MH  - Aberrant Crypt Foci/*drug therapy/prevention & control
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Chemoprevention
MH  - Colon/drug effects/pathology
MH  - Colonic Polyps/*drug therapy/prevention & control
MH  - Colorectal Neoplasms/*drug therapy/prevention & control
MH  - Double-Blind Method
MH  - Eicosapentaenoic Acid/*therapeutic use
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Rectum/drug effects/pathology
MH  - Treatment Outcome
PMC - PMC3515435
EDAT- 2012/09/21 06:00
MHDA- 2013/05/25 06:00
CRDT- 2012/09/21 06:00
PHST- 2012/06/25 00:00 [received]
PHST- 2012/07/13 00:00 [accepted]
PHST- 2012/09/21 06:00 [entrez]
PHST- 2012/09/21 06:00 [pubmed]
PHST- 2013/05/25 06:00 [medline]
AID - 1471-2407-12-413 [pii]
AID - 10.1186/1471-2407-12-413 [doi]
PST - epublish
SO  - BMC Cancer. 2012 Sep 19;12:413. doi: 10.1186/1471-2407-12-413.


PMID- 22991801
OWN - NLM
STAT- MEDLINE
DCOM- 20130103
LR  - 20151119
IS  - 0021-4892 (Print)
IS  - 0021-4892 (Linking)
VI  - 61
IP  - 8
DP  - 2012 Aug
TI  - [Perioperative fibrinogen concentrations in cardiac surgery with cardiopulmonary 
      bypass].
PG  - 814-9
AB  - BACKGROUND: Patients undergoing cardiac surgery with cardiopulmonary bypass (CPB)
      need many blood products due to deficiency of coagulation factors. Blood
      transfusion therapy in patients with excessive bleeding after CPB is generally
      empiric. We checked and studied the fibrinogen concentration and transfusion, as 
      well as bleeding amount in the perioperative period. METHODS: The study was
      approved by our institutional ethics committee. Thirty patients were studied.
      Blood samples were obtained at the induction of anesthesia (before CPB), at the
      end of CPB, at the end of operation, and on the next morning, or before the
      patient was given fresh frozen plasma in the intensive care unit. RESULTS: For
      all cases, fibrinogen concentration and platelet concentration were lowest at the
      end of CPB. Fibrinogen concentration rose up to before CPB level on the next
      morning. The group in which fibrinogen concentration was less than 150 mg x
      dl(-1) at the end of CPB consumed more blood products than the group with
      fibrinogen concentration of over 150 mg x dl(-1). CONCLUSIONS: Blood transfusion 
      therapy based on fibrinogen concentration is needed to maintain adequacy of the
      perioperative blood transfusion and blood conservation in cardiac surgery.
FAU - Uji, Makiko
AU  - Uji M
AD  - Department of Anesthesia, Tenri Hospital, Tenri 632-8552.
FAU - Terada, Yuki
AU  - Terada Y
FAU - Noguchi, Teruo
AU  - Noguchi T
FAU - Nishida, Takaya
AU  - Nishida T
FAU - Hasuwa, Kyoko
AU  - Hasuwa K
FAU - Shinohara, Kozue
AU  - Shinohara K
FAU - Kumano, Hotaka
AU  - Kumano H
FAU - Ishimura, Naoko
AU  - Ishimura N
FAU - Nishiwada, Makoto
AU  - Nishiwada M
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Masui
JT  - Masui. The Japanese journal of anesthesiology
JID - 0413707
RN  - 0 (Biomarkers)
RN  - 9001-32-5 (Fibrinogen)
SB  - IM
MH  - Biomarkers/blood
MH  - Blood Transfusion
MH  - *Cardiac Surgical Procedures
MH  - *Cardiopulmonary Bypass
MH  - Fibrinogen/*analysis
MH  - Humans
MH  - *Perioperative Period
MH  - Plasma
MH  - Postoperative Hemorrhage/*diagnosis/therapy
EDAT- 2012/09/21 06:00
MHDA- 2013/01/04 06:00
CRDT- 2012/09/21 06:00
PHST- 2012/09/21 06:00 [entrez]
PHST- 2012/09/21 06:00 [pubmed]
PHST- 2013/01/04 06:00 [medline]
PST - ppublish
SO  - Masui. 2012 Aug;61(8):814-9.


PMID- 22991778
OWN - NLM
STAT- MEDLINE
DCOM- 20121025
LR  - 20120920
IS  - 0034-8376 (Print)
IS  - 0034-8376 (Linking)
VI  - 64
IP  - 2
DP  - 2012 Mar-Apr
TI  - Changes in peripheral blood mononuclear cells glutamine synthetase mRNA after
      exercise in healthy volunteers: exploring an alternative proposal for non hepatic
      ammonia metabolism.
PG  - 164-72
AB  - BACKGROUND: Glutamine synthetase (GS) plays a central role in the inter-organ
      metabolism of ammonia and hepatic encephalopathy. The main objective of the
      present work was to disclose the possible effect of exercise on GS mRNA
      expression in peripheral blood mononuclear cells (PBMC) within a group of healthy
      volunteers. MATERIAL AND METHODS: PBMC were studied instead of skeletal muscle
      because of ethical concerns. Characterization of GS in lymphocytes was carried
      out by indirect immunofluorescence and Western blot. After a pilot trial,
      expression of GS mRNA in PBMC was assayed by serial measurements in healthy
      volunteers who had exercised on a treadmill, and on a control group who had not. 
      Muscle mass was estimated by bioimpedance. RESULTS: Cytoplasmic GS had a
      molecular weight of 44 kDa. Serial measurements of its mRNA demonstrated an
      increase in the treadmill (n = 29), but not in the control group (n = 13) (p <
      0.05). Peak expression occurred at 1 h in males and at 6 h in females. There was 
      a positive correlation between muscle mass and the increase of the enzyme mRNA
      after exercise. CONCLUSION: Exercise can increase the expression of GS mRNA in
      PBMC in healthy volunteers. Based on these preliminary results and on
      well-established physiological concepts, a hypothesis for non-hepatic ammonia
      metabolism is conceived. In the future could become part of the treatment of
      low-grade hepatic encephalopathy.
FAU - Duarte-Rojo, Andres
AU  - Duarte-Rojo A
AD  - Departmento de Gastroenterologia, Instituto Nacional de Ciencias Medicas y
      Nutricion Salvador Zubiran, Mexico, DF.
FAU - Torres-Vega, Miguel Angel
AU  - Torres-Vega MA
FAU - Villamil-Ramirez, Hugo
AU  - Villamil-Ramirez H
FAU - Estradas, Jose
AU  - Estradas J
FAU - Dominguez-Lopez, Aaron
AU  - Dominguez-Lopez A
FAU - Sanchez-Munoz, Fausto
AU  - Sanchez-Munoz F
FAU - Orea-Tejeda, Arturo
AU  - Orea-Tejeda A
FAU - Castillo-Martinez, Lilia
AU  - Castillo-Martinez L
FAU - Miliar-Garcia, Angel
AU  - Miliar-Garcia A
FAU - Macias-Rodriguez, Ricardo Ulises
AU  - Macias-Rodriguez RU
FAU - Torre, Aldo
AU  - Torre A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Mexico
TA  - Rev Invest Clin
JT  - Revista de investigacion clinica; organo del Hospital de Enfermedades de la
      Nutricion
JID - 9421552
RN  - 0 (RNA, Messenger)
RN  - 7664-41-7 (Ammonia)
RN  - EC 6.3.1.2 (Glutamate-Ammonia Ligase)
SB  - IM
MH  - Adult
MH  - Ammonia/*metabolism
MH  - Exercise/*physiology
MH  - Female
MH  - Glutamate-Ammonia Ligase/*genetics
MH  - Humans
MH  - Leukocytes, Mononuclear/enzymology/*metabolism
MH  - Liver/metabolism
MH  - Male
MH  - RNA, Messenger/biosynthesis
EDAT- 2012/09/21 06:00
MHDA- 2012/10/26 06:00
CRDT- 2012/09/21 06:00
PHST- 2012/09/21 06:00 [entrez]
PHST- 2012/09/21 06:00 [pubmed]
PHST- 2012/10/26 06:00 [medline]
PST - ppublish
SO  - Rev Invest Clin. 2012 Mar-Apr;64(2):164-72.


PMID- 27718823
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1351-5578 (Print)
IS  - 1351-5578 (Linking)
VI  - 20
IP  - 1
DP  - 2012 Sep 21
TI  - Making sense of research Making sense of research Fourth edition Pam Moule and
      Gill Hek Sage Publications pound20.99 200pp 9781849207799 1849207798 [Formula:
      see text].
PG  - 45
AB  - EACH SECTION of this publication, which is intended as an introduction to
      research, is easy to read to gain the 'bones' of the activities related to
      investigation. Sections include the nature of knowledge in health and social
      care, the research process, ethics, literature reviewing, data collection methods
      and analysis.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurse Res
JT  - Nurse researcher
JID - 9435953
EDAT- 2012/09/21 00:00
MHDA- 2012/09/21 00:01
CRDT- 2016/10/11 06:00
PHST- 2016/10/11 06:00 [entrez]
PHST- 2012/09/21 00:00 [pubmed]
PHST- 2012/09/21 00:01 [medline]
AID - 10.7748/nr.20.1.45.s4 [doi]
PST - ppublish
SO  - Nurse Res. 2012 Sep 21;20(1):45. doi: 10.7748/nr.20.1.45.s4.


PMID- 22990552
OWN - NLM
STAT- MEDLINE
DCOM- 20130417
LR  - 20120919
IS  - 2066-8279 (Electronic)
IS  - 1220-0522 (Linking)
VI  - 53
IP  - 3
DP  - 2012
TI  - Macroscopic, mesoscopic and microscopic morphology of the gastric
      plexus--ontogeny of the celiac ganglion.
PG  - 591-6
AB  - The vagus trunks, anterior and posterior, and their respective branches control
      the parasympathetic innervation of the stomach. After giving off a few thin
      branches, at the lower part of the esophagus and the cardiac region of the
      stomach, the anterior vagal trunk divides into its main branches: four or five
      consecutive direct branches which supply the upper part of the lesser curvature; 
      these nerves do not form plexuses and thus, they may be individually dissected.
      One of the branches is stronger than the others and is called the principal
      anterior nerve of the lesser curvature (anterior nerve of Latarjet). The present 
      study was conducted on eight fetuses of different gestational age (resulting from
      spontaneous abortions, without malformations), observing the Romanian laws of
      professional ethics, and 15 adult cadavers (male and female) whose celiac region 
      was dissected macro- and mesoscopically to reveal both the celiac ganglia and
      their afferent and efferent vessels. For the microscopic study, we used the
      Bielschowsky silver staining method. The meso- and macroscopic dissections
      revealed the anterior and posterior vagal trunks in all the specimens (100%), as 
      well as a rich gastric periarterial plexus. The microscopic samples focused on
      the ontogeny of the celiac ganglion in various gestational stages.
FAU - Sisu, Alina Maria
AU  - Sisu AM
AD  - Ist Department of Anatomy and Embryology, Victor Babes University of Medicine and
      Pharmacy, Timisoara, Romania. alinasisu@gmail.com
FAU - Stana, Loredana Gabriela
AU  - Stana LG
FAU - Petrescu, Codruta Ileana
AU  - Petrescu CI
FAU - Motoc, A
AU  - Motoc A
LA  - eng
PT  - Journal Article
PL  - Romania
TA  - Rom J Morphol Embryol
JT  - Romanian journal of morphology and embryology = Revue roumaine de morphologie et 
      embryologie
JID - 9112454
SB  - IM
MH  - Celiac Plexus/*anatomy & histology/*embryology
MH  - Female
MH  - Fetus/anatomy & histology
MH  - Ganglia, Sympathetic/*anatomy & histology/*embryology
MH  - Gestational Age
MH  - Humans
MH  - Male
MH  - Stomach/anatomy & histology/embryology/*innervation
MH  - Vagus Nerve/*anatomy & histology/*embryology
EDAT- 2012/09/20 06:00
MHDA- 2013/04/18 06:00
CRDT- 2012/09/20 06:00
PHST- 2012/09/20 06:00 [entrez]
PHST- 2012/09/20 06:00 [pubmed]
PHST- 2013/04/18 06:00 [medline]
AID - 530312591596 [pii]
PST - ppublish
SO  - Rom J Morphol Embryol. 2012;53(3):591-6.


PMID- 22990426
OWN - NLM
STAT- MEDLINE
DCOM- 20130107
LR  - 20181201
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 19
IP  - 5
DP  - 2012 Sep
TI  - Intensive care nurses' involvement in the end-of-life process--perspectives of
      relatives.
PG  - 666-76
AB  - In this article, we report findings from a qualitative study that explored how
      the relatives of intensive care unit patients experienced the nurses' role and
      relationship with them in the end-of-life decision-making processes. In all, 27
      relatives of 21 deceased patients were interviewed about their experiences in
      this challenging ethical issue. The findings reveal that despite bedside
      experiences of care, compassion and comfort, the nurses were perceived as vague
      and evasive in their communication, and the relatives missed a long-term
      perspective in the dialogue. Few experienced that nurses participated in meetings
      with doctors and relatives. The ethical consequences imply increased loneliness
      and uncertainty, and the experience that the relatives themselves have the
      responsibility of obtaining information and understanding their role in the
      decision-making process. The relatives therefore felt that the nurses could have 
      been more involved in the process.
FAU - Lind, Ranveig
AU  - Lind R
AD  - Intensive Care Unit, University Hospital of Northern Norway, Norway.
      Ranveig.Lind@unn.no
FAU - Lorem, Geir F
AU  - Lorem GF
FAU - Nortvedt, Per
AU  - Nortvedt P
FAU - Hevroy, Olav
AU  - Hevroy O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Decision Making
MH  - Family/psychology
MH  - Humans
MH  - *Intensive Care Units
MH  - *Nurse-Patient Relations
MH  - Professional Role
MH  - Terminal Care/*ethics
MH  - Workforce
EDAT- 2012/09/20 06:00
MHDA- 2013/01/08 06:00
CRDT- 2012/09/20 06:00
PHST- 2012/09/20 06:00 [entrez]
PHST- 2012/09/20 06:00 [pubmed]
PHST- 2013/01/08 06:00 [medline]
AID - 0969733011433925 [pii]
AID - 10.1177/0969733011433925 [doi]
PST - ppublish
SO  - Nurs Ethics. 2012 Sep;19(5):666-76. doi: 10.1177/0969733011433925.


PMID- 22990424
OWN - NLM
STAT- MEDLINE
DCOM- 20130107
LR  - 20220409
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 19
IP  - 5
DP  - 2012 Sep
TI  - 'Ambivalence' at the end of life: how to understand patients' wishes ethically.
PG  - 629-41
AB  - Health-care professionals in end-of-life care are frequently confronted with
      patients who seem to be 'ambivalent' about treatment decisions, especially if
      they express a wish to die. This article investigates this phenomenon by
      analysing two case stories based on narrative interviews with two patients and
      their caregivers. First, we argue that a respectful approach to patients requires
      acknowledging that coexistence of opposing wishes can be part of authentic,
      multi-layered experiences and moral understandings at the end of life. Second,
      caregivers need to understand when contradictory statements point to tensions in 
      a patient's moral experience that require support. Third, caregivers should be
      careful not to negatively label or even pathologize seemingly contradictory
      patient statements.
FAU - Ohnsorge, Kathrin
AU  - Ohnsorge K
AD  - Institute for Biomedical Ethics, University of Basel, Switzerland.
      kathrin.ohnsorge@unibas
FAU - Keller, Heike R Gudat
AU  - Keller HR
FAU - Widdershoven, Guy A M
AU  - Widdershoven GA
FAU - Rehmann-Sutter, Christoph
AU  - Rehmann-Sutter C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Attitude to Death
MH  - Caregivers/*ethics
MH  - Euthanasia
MH  - Humans
MH  - Living Wills
MH  - Moral Obligations
MH  - Narration
MH  - Neoplasms
MH  - Organizational Case Studies
MH  - Patient Care/*ethics
MH  - Patient Preference
MH  - *Personal Autonomy
MH  - Social Desirability
MH  - *Terminal Care
MH  - Terminally Ill
EDAT- 2012/09/20 06:00
MHDA- 2013/01/08 06:00
CRDT- 2012/09/20 06:00
PHST- 2012/09/20 06:00 [entrez]
PHST- 2012/09/20 06:00 [pubmed]
PHST- 2013/01/08 06:00 [medline]
AID - 0969733011436206 [pii]
AID - 10.1177/0969733011436206 [doi]
PST - ppublish
SO  - Nurs Ethics. 2012 Sep;19(5):629-41. doi: 10.1177/0969733011436206.


PMID- 22990423
OWN - NLM
STAT- MEDLINE
DCOM- 20130107
LR  - 20220317
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 19
IP  - 5
DP  - 2012 Sep
TI  - Defining end-of-life care from perspectives of nursing ethics.
PG  - 608-18
AB  - Despite increasing interests and urgent needs for quality end-of-life care, there
      is no exact definition of what is the interval referred to as end of life or what
      end-of-life care is. The purpose of this article is to report our examination of 
      terms related to end-of-life care and define end-of-life care from nursing ethics
      perspectives. Current terms related to end-of-life care, such as terminal care,
      hospice care, and palliative care, are based on a medical model and are
      restrictive in terms of diagnosis and prognosis. Using codes of ethics for nurses
      as a framework, we attempt to identify people to whom nurses are responsible to
      provide end-of-life care and develop a definition of end-of-life care that is
      more inclusive and applicable to a broader range of people who would benefit from
      end-of-life care by nurses and other health-care providers.
FAU - Izumi, Shigeko
AU  - Izumi S
AD  - Washington State University, Spokane 99210-1495, USA. seiko.izumi@wsu.edu
FAU - Nagae, Hiroko
AU  - Nagae H
FAU - Sakurai, Chihoko
AU  - Sakurai C
FAU - Imamura, Emiko
AU  - Imamura E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Acquired Immunodeficiency Syndrome
MH  - *Ethics, Nursing
MH  - HIV Infections/therapy
MH  - Hospice Care/*ethics
MH  - Humans
MH  - International Council of Nurses
MH  - Japan
MH  - Models, Nursing
MH  - Neoplasms/therapy
MH  - Nurse's Role
MH  - Nursing Care/*standards
MH  - Palliative Care
MH  - Practice Patterns, Nurses'
MH  - *Terminal Care/ethics
MH  - *Terminology as Topic
EDAT- 2012/09/20 06:00
MHDA- 2013/01/08 06:00
CRDT- 2012/09/20 06:00
PHST- 2012/09/20 06:00 [entrez]
PHST- 2012/09/20 06:00 [pubmed]
PHST- 2013/01/08 06:00 [medline]
AID - 0969733011436205 [pii]
AID - 10.1177/0969733011436205 [doi]
PST - ppublish
SO  - Nurs Ethics. 2012 Sep;19(5):608-18. doi: 10.1177/0969733011436205.


PMID- 22990421
OWN - NLM
STAT- MEDLINE
DCOM- 20130107
LR  - 20120919
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 19
IP  - 5
DP  - 2012 Sep
TI  - Nursing ethics perspectives on end-of-life care.
PG  - 603-4
FAU - Gastmans, Chris
AU  - Gastmans C
LA  - eng
PT  - Editorial
PT  - Introductory Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Codes of Ethics
MH  - *Ethics, Nursing
MH  - HIV Infections
MH  - Hospice Care/*ethics
MH  - Humans
MH  - International Council of Nurses
MH  - Japan
MH  - *Nurse's Role
MH  - Nurse-Patient Relations
MH  - Terminal Care/*ethics
EDAT- 2012/09/20 06:00
MHDA- 2013/01/08 06:00
CRDT- 2012/09/20 06:00
PHST- 2012/09/20 06:00 [entrez]
PHST- 2012/09/20 06:00 [pubmed]
PHST- 2013/01/08 06:00 [medline]
AID - 19/5/603 [pii]
AID - 10.1177/0969733012453234 [doi]
PST - ppublish
SO  - Nurs Ethics. 2012 Sep;19(5):603-4. doi: 10.1177/0969733012453234.


PMID- 22990160
OWN - NLM
STAT- MEDLINE
DCOM- 20131017
LR  - 20190608
IS  - 1518-8345 (Electronic)
IS  - 0104-1169 (Linking)
VI  - 20
IP  - 4
DP  - 2012 Jul-Aug
TI  - Nursing ethical processes in the State of Santa Catarina: characterization of
      factual elements.
PG  - 744-52
LID - S0104-11692012000400015 [pii]
AB  - OBJECTIVE: The present study aimed to characterize the processes of ethical and
      professional nursing transacted at the Regional Nursing Council of Santa Catarina
      (Coren/SC), considering their factual elements (events/offenses, causes and
      outcomes). METHOD: This descriptive, exploratory and documentary research with a 
      quantitative approach was developed at Coren/SC. Data was collected from 128
      professional ethical processes in nursing, between 1999 and 2007, analyzed
      descriptively with regard to the origin of the complaints and ethical processes, 
      the denouncers, the accused, the subject of the complaint and the outcome of the 
      process. RESULTS: Considering the topics, out of the eight categories described, 
      iatrogenesis was highlighted, as well as illegal professional practice,
      conflicting inter-professional relationships and professional responsibility of
      the nurse. CONCLUSION: The results show the need for discussion and intervention 
      in concrete practical and arouse reflections about the process of professional
      training and continuous education in the institutional spaces of health, in order
      to reduce ethical occurrences in professional practice.
FAU - Schneider, Dulcineia Ghizoni
AU  - Schneider DG
AD  - Universidade do Sul de Santa Catarina, Brazil.
FAU - Ramos, Flavia Regina Souza
AU  - Ramos FR
LA  - eng
LA  - por
LA  - spa
PT  - Journal Article
PL  - Brazil
TA  - Rev Lat Am Enfermagem
JT  - Revista latino-americana de enfermagem
JID - 9420934
MH  - Brazil
MH  - *Ethics, Nursing
MH  - Humans
MH  - Nursing Process/*ethics
EDAT- 2012/09/20 06:00
MHDA- 2013/10/18 06:00
CRDT- 2012/09/20 06:00
PHST- 2012/01/10 00:00 [received]
PHST- 2012/08/03 00:00 [accepted]
PHST- 2012/09/20 06:00 [entrez]
PHST- 2012/09/20 06:00 [pubmed]
PHST- 2013/10/18 06:00 [medline]
AID - S0104-11692012000400015 [pii]
AID - 10.1590/s0104-11692012000400015 [doi]
PST - ppublish
SO  - Rev Lat Am Enfermagem. 2012 Jul-Aug;20(4):744-52. doi:
      10.1590/s0104-11692012000400015.


PMID- 22989795
OWN - NLM
STAT- MEDLINE
DCOM- 20130307
LR  - 20220409
IS  - 1532-2653 (Electronic)
IS  - 0967-5868 (Linking)
VI  - 19
IP  - 11
DP  - 2012 Nov
TI  - The impact of enrollment in clinical trials on survival of patients with
      glioblastoma.
PG  - 1530-4
LID - 10.1016/j.jocn.2012.04.005 [doi]
LID - S0967-5868(12)00217-2 [pii]
AB  - The impact of enrollment in a clinical study on the survival of patients with
      glioblastoma has not been established. We retrospectively analyzed 564 patients
      with newly diagnosed glioblastoma treated between 1995 and 2008. They were
      divided into those enrolled in a clinical trial and randomized to a treatment or 
      control arm, and those not enrolled and who received best standard of care (BSC).
      The three groups were matched for age and Karnofsky performance scale (KPS) score
      at presentation, and included only patients who underwent at least one tumor
      resection. Survival analysis was performed and multivariate Cox proportional
      hazards model and recursive partitioning analysis (RPA) identified predictors of 
      survival. Following the matching process, 261 patients remained to form the final
      cohort. Of the 124 patients enrolled in a study, 81 (31.0%) were randomized to
      the treatment and 43 (16.5%) to the control arms. The overall median survival for
      the BSC (n=137), control, and treatment groups was 11.57 months (95% confidence
      interval [CI], 10.41-12.73), 16.27 months (95% CI, 14.10-18.43) and 16.10 months 
      (95% CI, 14.34-17.86), respectively (p=0.002). Participation in a clinical trial,
      regardless of the arm, was a significant predictor of survival, as were age and
      KPS at diagnosis. The RPA also demonstrated a favorable impact of participation
      in a clinical trial. Additional tumor resections and various treatment modalities
      were administered with significantly higher frequency among patients enrolled in 
      clinical studies. Thus, enrollment in a clinical study carried a significant
      survival advantage for patients with glioblastoma, raising practical and ethical 
      issues regarding the quality of care of patients who receive "standard" therapy.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Shahar, Tal
AU  - Shahar T
AD  - Department of Neurosurgery, Tel Aviv Medical Center, 6 Weizman Street, Tel Aviv
      64239, Israel.
FAU - Nossek, Erez
AU  - Nossek E
FAU - Steinberg, David M
AU  - Steinberg DM
FAU - Rozovski, Uri
AU  - Rozovski U
FAU - Blumenthal, Deborah T
AU  - Blumenthal DT
FAU - Bokstein, Felix
AU  - Bokstein F
FAU - Sitt, Razi
AU  - Sitt R
FAU - Freedman, Sigal
AU  - Freedman S
FAU - Corn, Benjamin W
AU  - Corn BW
FAU - Kanner, Andrew A
AU  - Kanner AA
FAU - Ram, Zvi
AU  - Ram Z
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20120916
PL  - Scotland
TA  - J Clin Neurosci
JT  - Journal of clinical neuroscience : official journal of the Neurosurgical Society 
      of Australasia
JID - 9433352
SB  - IM
MH  - Aged
MH  - Brain Neoplasms/surgery/*therapy
MH  - Case Management
MH  - Clinical Trials as Topic/*statistics & numerical data
MH  - Female
MH  - Glioblastoma/surgery/*therapy
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Karnofsky Performance Status
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Regression Analysis
MH  - Retrospective Studies
MH  - Survival Analysis
MH  - Treatment Outcome
EDAT- 2012/09/20 06:00
MHDA- 2013/03/08 06:00
CRDT- 2012/09/20 06:00
PHST- 2012/03/31 00:00 [received]
PHST- 2012/04/04 00:00 [accepted]
PHST- 2012/09/20 06:00 [entrez]
PHST- 2012/09/20 06:00 [pubmed]
PHST- 2013/03/08 06:00 [medline]
AID - S0967-5868(12)00217-2 [pii]
AID - 10.1016/j.jocn.2012.04.005 [doi]
PST - ppublish
SO  - J Clin Neurosci. 2012 Nov;19(11):1530-4. doi: 10.1016/j.jocn.2012.04.005. Epub
      2012 Sep 16.


PMID- 22989135
OWN - NLM
STAT- MEDLINE
DCOM- 20130409
LR  - 20120919
IS  - 1365-2923 (Electronic)
IS  - 0308-0110 (Linking)
VI  - 46
IP  - 10
DP  - 2012 Oct
TI  - Medical misconduct in Hong Kong: implications for medical education around the
      world.
PG  - 1009-16
LID - 10.1111/j.1365-2923.2012.04349.x [doi]
AB  - CONTEXT: Medical educators emphasise responses to medical misconduct, but little 
      is known about medical misconduct and its implications for medical education.
      This article investigates the nature of medical malpractice in Hong Kong and
      offers guidance for the inclusion of a curriculum to prevent the occurrence of
      medical misconduct in medical education around the world. METHODS: A
      comprehensive review of judgements made by the Medical Council of Hong Kong
      during the period from July 2008 to December 2010 was conducted. Each of the 40
      cases of inquiry related to medical misconduct were summarised and analysed
      according to 14 factors. RESULTS: Of the 40 cases, nearly half involved only one 
      or two charges. The Council found the defendants guilty of professional
      misconduct on 148 of 169 charges, and ordered the following four types of
      penalty: removal order, suspension, warning letter, and reprimand. Cases are
      grouped into three categories involving: improper documentation, inappropriate
      management or prescription of drugs, and failure to interact appropriately with
      patients. The relevant ethical codes or legislation for each category are
      illustrated. CONCLUSIONS: Various types of medical misconduct unquestionably
      caused suffering to the patients involved, their families and society. Hence, it 
      is crucial for medical educators to teach students about the importance of
      medical ethics and the prevention of misconduct.
CI  - (c) Blackwell Publishing Ltd 2012.
FAU - Chan, Zenobia C Y
AU  - Chan ZC
AD  - School of Nursing, The Hong Kong Polytechnic University, Hong Kong, China.
      hszchan@inet.polyu.edu.hk
LA  - eng
PT  - Journal Article
PL  - England
TA  - Med Educ
JT  - Medical education
JID - 7605655
SB  - IM
MH  - Curriculum/standards
MH  - Education, Medical/*standards
MH  - Hong Kong
MH  - Humans
MH  - Legislation, Medical/standards
MH  - Professional Misconduct/*statistics & numerical data
EDAT- 2012/09/20 06:00
MHDA- 2013/04/10 06:00
CRDT- 2012/09/20 06:00
PHST- 2012/09/20 06:00 [entrez]
PHST- 2012/09/20 06:00 [pubmed]
PHST- 2013/04/10 06:00 [medline]
AID - 10.1111/j.1365-2923.2012.04349.x [doi]
PST - ppublish
SO  - Med Educ. 2012 Oct;46(10):1009-16. doi: 10.1111/j.1365-2923.2012.04349.x.


PMID- 22989021
OWN - NLM
STAT- MEDLINE
DCOM- 20130531
LR  - 20211021
IS  - 1471-244X (Electronic)
IS  - 1471-244X (Linking)
VI  - 12
DP  - 2012 Sep 18
TI  - The systematic activation method as a nursing intervention in depressed elderly: 
      a protocol for a multi-centre cluster randomized trial.
PG  - 144
LID - 10.1186/1471-244X-12-144 [doi]
AB  - BACKGROUND: Depression in later life is a common mental disorder with a
      prevalence rate of between 3% and 35% for minor depression and approximately 2%
      for Major Depressive Disorder (MDD). The most common treatment modalities for MDD
      are antidepressant medication and psychological interventions. Recently,
      Behavioral Activation (BA) has gained renewed attention as an effective treatment
      modality in MDD. Although BA is considered an easy accessible intervention for
      both patients and health care workers (such as nurses), there is no research on
      the effectiveness of the intervention in inpatient depressed elderly.The aim of
      study, described in the present proposal, is to examine the effects of BA when
      executed by nurses in an inpatient population of elderly persons with MDD.
      METHODS/DESIGN: The study is designed as a multi-center cluster randomized
      controlled trial. BA, described as The Systematic Activation Method (SAM) will be
      compared with Treatment as Usual (TAU). We aim to include ten mental health care 
      units in the Netherlands that will each participate as a control unit or an
      experimental unit. The patients will meet the following criteria: (1) a primary
      diagnosis of Major Depressive Disorder (MDD) according to the DSM-IV criteria;
      (2) 60 years or older; (3) able to read and write in Dutch; (4) have consented to
      participate via the informed consent procedure. Based on an effect size d = 0.7, 
      we intend to include 51 participants per condition (n = 102). The SAM will be
      implemented within the experimental units as an adjunctive therapy to Treatment
      As Usual (TAU). All patients will be assessed at baseline, after eight weeks, and
      after six months. The primary outcome will be the level of depression measured by
      means of the Beck Depression Inventory (Dutch version). Other assessments will be
      activity level, mastery, costs, anxiety and quality of life. DISCUSSION: To our
      knowledge this is the first study to test the effect of Behavioral Activation as 
      a nursing intervention in an inpatient elderly population. This research has been
      approved by the medical research ethics committee for health-care settings in the
      Netherlands (No. NL26878.029.09) and is listed in the Dutch Trial Register (NTR
      No.1809).
FAU - Clignet, Frans
AU  - Clignet F
AD  - Department of Clinical Psychiatry, VU University, Van Der Boechorststraat 1,
      Amsterdam, the Netherlands. Fghm.clignet@psy.vu.nl
FAU - van Meijel, Berno
AU  - van Meijel B
FAU - van Straten, Annemiek
AU  - van Straten A
FAU - Cuijpers, Pim
AU  - Cuijpers P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120918
PL  - England
TA  - BMC Psychiatry
JT  - BMC psychiatry
JID - 100968559
SB  - IM
MH  - Aged
MH  - Cognitive Behavioral Therapy/*methods
MH  - Depressive Disorder, Major/economics/*nursing/psychology
MH  - Follow-Up Studies
MH  - Humans
MH  - Inpatients
MH  - Middle Aged
MH  - Multicenter Studies as Topic/methods
MH  - Netherlands
MH  - Psychiatric Nursing
MH  - Psychiatric Status Rating Scales
MH  - Randomized Controlled Trials as Topic/*methods
MH  - Research Design/*standards
MH  - Treatment Outcome
MH  - Workforce
PMC - PMC3514113
EDAT- 2012/09/20 06:00
MHDA- 2013/06/01 06:00
CRDT- 2012/09/20 06:00
PHST- 2012/09/10 00:00 [received]
PHST- 2012/09/10 00:00 [accepted]
PHST- 2012/09/20 06:00 [entrez]
PHST- 2012/09/20 06:00 [pubmed]
PHST- 2013/06/01 06:00 [medline]
AID - 1471-244X-12-144 [pii]
AID - 10.1186/1471-244X-12-144 [doi]
PST - epublish
SO  - BMC Psychiatry. 2012 Sep 18;12:144. doi: 10.1186/1471-244X-12-144.


PMID- 22988327
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120919
LR  - 20211021
IS  - 1998-3794 (Electronic)
IS  - 0019-5545 (Linking)
VI  - 54
IP  - 2
DP  - 2012 Apr
TI  - Euthanasia: An Indian perspective.
PG  - 177-83
LID - 10.4103/0019-5545.99537 [doi]
AB  - In our society, the palliative care and quality of life issues in patients with
      terminal illnesses like advanced cancer and AIDS have become an important concern
      for clinicians. Parallel to this concern has arisen another controversial
      issue-euthanasia or "mercy -killing" of terminally ill patients. Proponents of
      physician-assisted suicide (PAS) feel that an individual's right to autonomy
      automatically entitles him to choose a painless death. The opponents feel that a 
      physician's role in the death of an individual violates the central tenet of the 
      medical profession. Moreover, undiagnosed depression and possibility of social
      'coercion' in people asking for euthanasia put a further question mark on the
      ethical principles underlying such an act. These concerns have led to strict
      guidelines for implementing PAS. Assessment of the mental state of the person
      consenting to PAS becomes mandatory and here, the role of the psychiatrist
      becomes pivotal. Although considered illegal in our country, PAS has several
      advocates in the form of voluntary organizations like "death with dignity"
      foundation. This has got a fillip in the recent Honourable Supreme Court Judgment
      in the Aruna Shaunbag case. What remains to be seen is how long it takes before
      this sensitive issue rattles the Indian legislature.
FAU - Sinha, Vinod K
AU  - Sinha VK
AD  - Department of Child and Adolescent Psychiatry, Central Institute of Psychiatry,
      Kanke, Ranchi, Jharkhand, India.
FAU - Basu, S
AU  - Basu S
FAU - Sarkhel, S
AU  - Sarkhel S
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Psychiatry
JT  - Indian journal of psychiatry
JID - 0013255
PMC - PMC3440914
OTO - NOTNLM
OT  - Euthanasia
OT  - palliative care
OT  - physician-assisted suicide
EDAT- 2012/09/19 06:00
MHDA- 2012/09/19 06:01
CRDT- 2012/09/19 06:00
PHST- 2012/09/19 06:00 [entrez]
PHST- 2012/09/19 06:00 [pubmed]
PHST- 2012/09/19 06:01 [medline]
AID - 10.4103/0019-5545.99537 [doi]
AID - IJPsy-54-177 [pii]
PST - ppublish
SO  - Indian J Psychiatry. 2012 Apr;54(2):177-83. doi: 10.4103/0019-5545.99537.


PMID- 22987619
OWN - NLM
STAT- MEDLINE
DCOM- 20130401
LR  - 20121003
IS  - 1099-0801 (Electronic)
IS  - 0269-3879 (Linking)
VI  - 26
IP  - 11
DP  - 2012 Nov
TI  - Submission of scientifically sound and ethical manuscripts to peer-reviewed
      journals - a reviewer's personal perspective on bioanalytical publications.
PG  - 1457-60
LID - 10.1002/bmc.2817 [doi]
AB  - In the pharmaceutical industry, bioanalysis is very dynamic and is probably one
      of the few fields of research covering the entire drug discovery, development and
      post-marketing process. Important decisions on drug safety can partially rely on 
      bioanalytical data, which therefore can be subject to regulatory scrutiny.
      Bioanalytical scientists have historically contributed significant numbers of
      scientific manuscripts in many peer-reviewed analytical journals. All of these
      journals provide some high-level instructions, but they also leave sufficient
      flexibility for reviewers to perform independent critique and offer
      recommendations for each submitted manuscript. Reviewers play a pivotal role in
      the process of bioanalytical publication to ensure the publication of
      high-quality manuscripts in a timely fashion. Their efforts usually lead to
      improved manuscripts. However, it has to be a joint effort among authors,
      reviewers and editors to promote scientifically sound and ethically fair
      bioanalytical publications. Most of the submitted manuscripts were well written
      with only minor or moderate revisions required for further improvement.
      Nevertheless, there were small numbers of submitted manuscripts that did not meet
      the requirements for publications because of scientific or ethical deficiencies, 
      which are discussed in this Letter to the Editor.
CI  - Copyright (c) 2012 John Wiley & Sons, Ltd.
FAU - Weng, Naidong
AU  - Weng N
AD  - Janssen Research and Development, Global Development Operations, 1000 US Highway 
      202, Raritan, NJ, 08869, USA. NWeng@its.jnj.com
LA  - eng
PT  - Journal Article
DEP - 20120917
PL  - England
TA  - Biomed Chromatogr
JT  - Biomedical chromatography : BMC
JID - 8610241
SB  - IM
MH  - Biomedical Research/*ethics/*standards
MH  - Humans
MH  - *Peer Review, Research
MH  - Periodicals as Topic
MH  - Publishing/*ethics/*standards
MH  - Scientific Misconduct
EDAT- 2012/09/19 06:00
MHDA- 2013/04/02 06:00
CRDT- 2012/09/19 06:00
PHST- 2012/08/21 00:00 [received]
PHST- 2012/08/23 00:00 [accepted]
PHST- 2012/09/19 06:00 [entrez]
PHST- 2012/09/19 06:00 [pubmed]
PHST- 2013/04/02 06:00 [medline]
AID - 10.1002/bmc.2817 [doi]
PST - ppublish
SO  - Biomed Chromatogr. 2012 Nov;26(11):1457-60. doi: 10.1002/bmc.2817. Epub 2012 Sep 
      17.


PMID- 22987273
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20120918
IS  - 1988-9518 (Electronic)
IS  - 0214-3429 (Linking)
VI  - 25
IP  - 3
DP  - 2012 Sep
TI  - [Consensus document on vaccination against influenza in health care workers].
PG  - 226-39
AB  - Health care workers (HCW) are included each year among risk groups for
      vaccination against influenza. However, vaccination coverage among this group in 
      our country is very low, not exceeding 25%. Convinced that one of the best tools 
      to increase this coverage among professionals in our country are the scientific
      evidence, 19 scientific societies and associations professionals bringing
      together health professionals more directly related to influenza as an health
      problem, and the General Nursing Council, met to discuss and develop this
      consensus document in order to inform HCW about the appropriateness of their
      vaccination against influenza and the benefits that flow from it for themselves, 
      for their patients and for the rest of the population. This recommendation is
      based on 3 pillars: argument of necessity, ethics and exemplary.
FAU - Picazo, J J
AU  - Picazo JJ
AD  - Servicio de Microbiologia Clinica, Hospital Clinico San Carlos, Madrid, Spain.
      jpicazo@microb.net
FAU - Alonso, L M
AU  - Alonso LM
FAU - Aristegui, J
AU  - Aristegui J
FAU - Bayas, J M
AU  - Bayas JM
FAU - Sanz, J
AU  - Sanz J
FAU - Del Amo, P
AU  - Del Amo P
FAU - Cobos, J L
AU  - Cobos JL
FAU - Rodriguez-Salazar, J
AU  - Rodriguez-Salazar J
FAU - Sanchez-Pastor, M
AU  - Sanchez-Pastor M
FAU - de la Camara, R
AU  - de la Camara R
FAU - Carratala, J
AU  - Carratala J
FAU - Canada, J L
AU  - Canada JL
FAU - Gonzalez-Del Castillo, J
AU  - Gonzalez-Del Castillo J
FAU - Aldaz, P
AU  - Aldaz P
FAU - Perez-Escanilla, F
AU  - Perez-Escanilla F
FAU - Barberan, J
AU  - Barberan J
FAU - Rodriguez, A
AU  - Rodriguez A
FAU - Vigil-Escribano, D
AU  - Vigil-Escribano D
FAU - Espinosa-Arranz, J
AU  - Espinosa-Arranz J
FAU - Blanquer, J
AU  - Blanquer J
FAU - Gonzalez-Romo, F
AU  - Gonzalez-Romo F
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Consenso sobre la vacunacion frente a la gripe en el personal sanitario.
PL  - Spain
TA  - Rev Esp Quimioter
JT  - Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola
      de Quimioterapia
JID - 9108821
RN  - 0 (Influenza Vaccines)
SB  - IM
MH  - Consensus
MH  - Guidelines as Topic
MH  - *Health Personnel/ethics
MH  - Humans
MH  - Influenza Vaccines
MH  - Influenza, Human/*prevention & control
MH  - Spain/epidemiology
MH  - Vaccination/ethics/*standards
EDAT- 2012/09/19 06:00
MHDA- 2013/02/13 06:00
CRDT- 2012/09/19 06:00
PHST- 2012/09/19 06:00 [entrez]
PHST- 2012/09/19 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
AID - picazo [pii]
PST - ppublish
SO  - Rev Esp Quimioter. 2012 Sep;25(3):226-39.


PMID- 22986563
OWN - NLM
STAT- MEDLINE
DCOM- 20130222
LR  - 20191027
IS  - 1710-2774 (Print)
IS  - 1710-2774 (Linking)
VI  - 15
IP  - 3
DP  - 2012
TI  - Ethical framework for resource allocation during a drug supply shortage.
PG  - 26-35
AB  - Drug supply shortages are common in health systems due to manufacturing and other
      delays. Frequently, shortages are successfully addressed through conservation and
      redistribution efforts, with limited impact on patient care. However, when Sandoz
      Canada Inc. announced in February 2012 that it was reducing production of a
      number of generic injectable drugs at its Quebec facility, the scope and
      magnitude of the drug supply shortage were unprecedented in Canada. The potential
      for an extreme scarcity of some drugs raised ethical concerns about patient care,
      including the need to limit access to some health services. In this article, the 
      authors describe the development and implementation of an ethical framework to
      promote equitable access to drugs and healthcare services in the context of a
      drug supply shortage within and across health systems.
FAU - Gibson, Jennifer L
AU  - Gibson JL
AD  - University of Toronto Joint Centre for Bioethics, Toronto, Ontario, Canada.
      jennifer.gibson@utoronto.ca
FAU - Bean, Sally
AU  - Bean S
FAU - Chidwick, Paula
AU  - Chidwick P
FAU - Godkin, Dianne
AU  - Godkin D
FAU - Sibbald, Robert W
AU  - Sibbald RW
FAU - Wagner, Frank
AU  - Wagner F
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Healthc Q
JT  - Healthcare quarterly (Toronto, Ont.)
JID - 101208192
RN  - 0 (Pharmaceutical Preparations)
MH  - Canada
MH  - Health Care Rationing/*ethics/*organization & administration
MH  - Health Plan Implementation
MH  - Humans
MH  - Pharmaceutical Preparations/*supply & distribution
MH  - Software Design
EDAT- 2012/09/19 06:00
MHDA- 2013/02/23 06:00
CRDT- 2012/09/19 06:00
PHST- 2012/09/19 06:00 [entrez]
PHST- 2012/09/19 06:00 [pubmed]
PHST- 2013/02/23 06:00 [medline]
AID - 10.12927/hcq.2013.23040 [doi]
PST - ppublish
SO  - Healthc Q. 2012;15(3):26-35. doi: 10.12927/hcq.2013.23040.


PMID- 22985894
OWN - NLM
STAT- MEDLINE
DCOM- 20131231
LR  - 20181201
IS  - 1488-2159 (Electronic)
IS  - 0709-8936 (Linking)
VI  - 78
DP  - 2012
TI  - Ethical and clinical responsibilities of dentists.
PG  - c100; author reply c108
FAU - Stoopler, Eric T
AU  - Stoopler ET
FAU - Sollecito, Thomas P
AU  - Sollecito TP
LA  - eng
PT  - Letter
PT  - Comment
PL  - Canada
TA  - J Can Dent Assoc
JT  - Journal (Canadian Dental Association)
JID - 7907605
SB  - IM
CON - J Can Dent Assoc. 2012;78:c75. PMID: 22889502
MH  - Biopsy/*methods
MH  - Humans
MH  - Mouth Diseases/*pathology
MH  - Mouth Mucosa/*pathology
EDAT- 2012/09/19 06:00
MHDA- 2014/01/01 06:00
CRDT- 2012/09/19 06:00
PHST- 2012/09/19 06:00 [entrez]
PHST- 2012/09/19 06:00 [pubmed]
PHST- 2014/01/01 06:00 [medline]
PST - ppublish
SO  - J Can Dent Assoc. 2012;78:c100; author reply c108.


PMID- 22985871
OWN - NLM
STAT- MEDLINE
DCOM- 20130304
LR  - 20181202
IS  - 1878-0539 (Electronic)
IS  - 1748-6815 (Linking)
VI  - 66
IP  - 1
DP  - 2013 Jan
TI  - Failure of plastic surgical clinical trials to document compliance with
      international ethical guidelines: a systematic review.
PG  - 3-8
LID - 10.1016/j.bjps.2012.07.005 [doi]
LID - S1748-6815(12)00411-1 [pii]
AB  - BACKGROUND: The Declaration of Helsinki (DOH) mandates that clinical trials must 
      follow specific ethical standards including independent ethical review and
      registration in a public database to protect the rights and safety of human
      subjects and promote public trust. The purpose of this study was to perform a
      systematic review to identify whether independent ethical review and trial
      registration had been documented in all prospective clinical studies published in
      the journals Plastic and Reconstructive Surgery, Annals of Plastic Surgery and
      the Journal of Plastic Reconstructive and Aesthetic Surgery from 7/2007 to 7/2011
      and if there was any difference in documentation between journals and between
      types of studies. METHODS: The PubMed database was selected to search through the
      medical literature with specific inclusion criteria to disqualify irrelevant
      articles from the study. Appropriate articles were extracted, and all
      investigators assessed their quality and validity to maximize reproducibility.
      Each investigator systematically reviewed every article to determine whether
      independent ethical review and trial registration had been reported. Each
      investigator staged every study using the 2011 Oxford Centre for Evidence Based
      Medicine criteria. The data were then synthesized and analyzed for documentation 
      of independent ethical review and trial registration. RESULTS: Of the 235 studies
      retrieved, 155 met our inclusion criteria as prospective studies, 102 reported
      independent ethical review. Eight studies reported trial registration in a public
      database, two additional studies were registered at clinicaltrials.gov, but the
      publications did not document their registration. Seven of the reported studies
      did not comply with the DOH as they had been registered retroactively; thus only 
      one study out of 155 (<1%) documented compliance with the DOH. Using Fisher's
      exact test, the only statistically significant difference between the groups was 
      better documentation in PRS level 2 studies than in PRS level 3 studies (p =
      0.007). CONCLUSION: Plastic surgery clinical trials' documentation of compliance 
      with international ethical guidelines must improve.
CI  - Copyright (c) 2012 British Association of Plastic, Reconstructive and Aesthetic
      Surgeons. Published by Elsevier Ltd. All rights reserved.
FAU - Freshwater, M Felix
AU  - Freshwater MF
AD  - Voluntary Professor of Surgery, University of Miami School of Medicine, 9100 S.
      Dadeland Blvd. Suite 502, Miami, FL 33156-7815, USA. mfelix.freshwater@gmail.com
FAU - Garcia-Zalisnak, D E
AU  - Garcia-Zalisnak DE
FAU - Gonzalez-Ortiz, N E
AU  - Gonzalez-Ortiz NE
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20120915
PL  - Netherlands
TA  - J Plast Reconstr Aesthet Surg
JT  - Journal of plastic, reconstructive & aesthetic surgery : JPRAS
JID - 101264239
SB  - IM
CIN - J Plast Reconstr Aesthet Surg. 2013 May;66(5):738-9. PMID: 23402934
MH  - Clinical Trials as Topic/ethics/*standards
MH  - Documentation/*standards
MH  - *Ethical Review
MH  - Guideline Adherence
MH  - Helsinki Declaration
MH  - Humans
MH  - Periodicals as Topic/standards
MH  - Practice Guidelines as Topic
MH  - *Surgery, Plastic
EDAT- 2012/09/19 06:00
MHDA- 2013/03/05 06:00
CRDT- 2012/09/19 06:00
PHST- 2012/04/12 00:00 [received]
PHST- 2012/05/28 00:00 [revised]
PHST- 2012/07/02 00:00 [accepted]
PHST- 2012/09/19 06:00 [entrez]
PHST- 2012/09/19 06:00 [pubmed]
PHST- 2013/03/05 06:00 [medline]
AID - S1748-6815(12)00411-1 [pii]
AID - 10.1016/j.bjps.2012.07.005 [doi]
PST - ppublish
SO  - J Plast Reconstr Aesthet Surg. 2013 Jan;66(1):3-8. doi:
      10.1016/j.bjps.2012.07.005. Epub 2012 Sep 15.


PMID- 22985714
OWN - NLM
STAT- MEDLINE
DCOM- 20130226
LR  - 20121123
IS  - 1049-023X (Print)
IS  - 1049-023X (Linking)
VI  - 27
IP  - 6
DP  - 2012 Dec
TI  - Ethical considerations in embedding a surgeon in a military or civilian tactical 
      team.
PG  - 583-8
LID - 10.1017/S1049023X12001112 [doi]
AB  - Tactical emergency medical services (TEMS) bring immediate medical support to the
      inner perimeter of special weapons and tactics team activations. While initially 
      envisioned as a role for an individual dually trained as a police officer and
      paramedic, TEMS is increasingly undertaken by physicians and paramedics who are
      not police officers. This report explores the ethical underpinnings of embedding 
      a surgeon within a military or civilian tactical team with regard to identity,
      ethically acceptable actions, triage, responsibility set, training,
      certification, and potential future refinements of the role of the tactical
      police surgeon.
FAU - Kaplan, Lewis J
AU  - Kaplan LJ
AD  - Department of Surgery, Yale University School of Medicine, New Haven, CT 06520,
      USA. Lewis.Kaplan@yale.edu
FAU - Siegel, Mark D
AU  - Siegel MD
FAU - Eastman, Alexander L
AU  - Eastman AL
FAU - Flynn, Lisa M
AU  - Flynn LM
FAU - Rosenbaum, Stanley H
AU  - Rosenbaum SH
FAU - Cone, David C
AU  - Cone DC
FAU - Blake, David P
AU  - Blake DP
FAU - Mulhern, Jonathan
AU  - Mulhern J
LA  - eng
PT  - Journal Article
DEP - 20120821
PL  - United States
TA  - Prehosp Disaster Med
JT  - Prehospital and disaster medicine
JID - 8918173
MH  - Decision Making
MH  - Emergency Medical Technicians/ethics
MH  - General Surgery/*ethics
MH  - Humans
MH  - Military Medicine/*ethics
MH  - Military Personnel
MH  - *Physician's Role
MH  - Police/*ethics
MH  - Triage
EDAT- 2012/09/19 06:00
MHDA- 2013/02/27 06:00
CRDT- 2012/09/19 06:00
PHST- 2012/09/19 06:00 [entrez]
PHST- 2012/09/19 06:00 [pubmed]
PHST- 2013/02/27 06:00 [medline]
AID - S1049023X12001112 [pii]
AID - 10.1017/S1049023X12001112 [doi]
PST - ppublish
SO  - Prehosp Disaster Med. 2012 Dec;27(6):583-8. doi: 10.1017/S1049023X12001112. Epub 
      2012 Aug 21.


PMID- 22985217
OWN - NLM
STAT- MEDLINE
DCOM- 20130807
LR  - 20181202
IS  - 1557-7708 (Electronic)
IS  - 1075-5535 (Linking)
VI  - 19
IP  - 2
DP  - 2013 Feb
TI  - Prevalence and predictors of selenium and vitamin E supplementation in a urology 
      population.
PG  - 128-33
LID - 10.1089/acm.2011.0184 [doi]
AB  - OBJECTIVES: Preclinical and epidemiological studies have suggested the use of
      supplements such as selenium and vitamin E for prostate cancer (PCa) prevention; 
      however, clinical trials have not demonstrated clear benefit in patients. This
      study aims to investigate the current prevalence and predictors for use of these 
      supplements in men in a urology population. DESIGN, SUBJECTS, AND OUTCOMES
      MEASURED: Three hundred and twelve (312) men visiting the Princess Margaret
      Hospital Ambulatory Urology Clinic were enrolled in this University Health
      Network Research Ethics Board-approved questionnaire-based study investigating
      supplement use, reasons for use and demographic characteristics. RESULTS: It was 
      observed that 13.5% and 20.8% of the participants are currently using selenium
      and vitamin E, respectively, while 10.6% and 15.7% previously used selenium and
      vitamin E, respectively. Both education (percentage of users comparing less than 
      college education versus college or above education: selenium: 14% versus 28%;
      p=0.008, vitamin E: 26% versus 41%; p=0.013) and health literacy (mean
      scores+/-standard error of the mean of users versus nonusers: selenium question
      1: 1.4507+/-0.09576 versus 1.6083+/-0.07211; p=0.023, selenium question 2:
      2.8750+/-0.04395 versus 2.7106+/-0.03774; p=0.000, selenium question 3:
      1.4583+/-0.08377 versus 1.7064+/-0.06278; p=0.025, vitamin E question 1:
      2.8036+/-0.04545 versus 2.7179+/-0.04097; p=0.010, vitamin E question 2:
      1.5446+/-0.06698 versus 1.7077+/-0.07241; p=0.006) are predictors of selenium and
      vitamin E use on univariable analysis. On multivariable analysis education
      (selenium odds ratio=2.095, 95% confidence interval=1.019-4.305, p=0.044; vitamin
      E odds ratio=1.855, 95% confidence interval=1.015-3.338, p=0.045) remains a
      significant predictor of selenium and vitamin E use. Examining the data on use by
      education, it was found that more men with a higher education attributed their
      use of selenium to urologist advice (24%), and those with a lower education
      attributed their use of selenium to naturopath/homeopath advice (28%).
      CONCLUSIONS: Many men who visit urology clinics use selenium and vitamin E
      despite the lack of clinical support for chemoprevention. Education and health
      literacy are important variables in determining the use of these supplements in
      these men. This information may aid in addressing the needs of the diverse
      patient population using these supplements for the prevention of PCa.
FAU - Locke, Jennifer
AU  - Locke J
AD  - Urology Program, Princess Margaret Hospital-University Health Network, Toronto,
      Ontario, Canada. jennifer.locke@utoronto.ca
FAU - Hersey, Karen
AU  - Hersey K
FAU - Margel, David
AU  - Margel D
FAU - Sorokin, Kevin
AU  - Sorokin K
FAU - Fleshner, Neil
AU  - Fleshner N
LA  - eng
PT  - Journal Article
DEP - 20120917
PL  - United States
TA  - J Altern Complement Med
JT  - Journal of alternative and complementary medicine (New York, N.Y.)
JID - 9508124
RN  - 0 (Antioxidants)
RN  - 0 (Micronutrients)
RN  - 1406-18-4 (Vitamin E)
RN  - H6241UJ22B (Selenium)
SB  - IM
MH  - Adult
MH  - Antioxidants/therapeutic use
MH  - Dietary Supplements/*statistics & numerical data
MH  - *Educational Status
MH  - *Health Literacy
MH  - Humans
MH  - Male
MH  - Micronutrients/*therapeutic use
MH  - Multivariate Analysis
MH  - Prostatic Neoplasms/*prevention & control
MH  - Selenium/*therapeutic use
MH  - Surveys and Questionnaires
MH  - Urology/methods
MH  - Vitamin E/*therapeutic use
EDAT- 2012/09/19 06:00
MHDA- 2013/08/08 06:00
CRDT- 2012/09/19 06:00
PHST- 2012/09/19 06:00 [entrez]
PHST- 2012/09/19 06:00 [pubmed]
PHST- 2013/08/08 06:00 [medline]
AID - 10.1089/acm.2011.0184 [doi]
PST - ppublish
SO  - J Altern Complement Med. 2013 Feb;19(2):128-33. doi: 10.1089/acm.2011.0184. Epub 
      2012 Sep 17.


PMID- 22985153
OWN - NLM
STAT- MEDLINE
DCOM- 20121130
LR  - 20131121
IS  - 1532-5415 (Electronic)
IS  - 0002-8614 (Linking)
VI  - 60
IP  - 9
DP  - 2012 Sep
TI  - A case of Diogenes syndrome: clinical and ethical challenges.
PG  - 1780-1
LID - 10.1111/j.1532-5415.2012.04128.x [doi]
FAU - Bonci, Gregory
AU  - Bonci G
AD  - Weill Medical College, Cornell University, Westchester Division, White Plains,
      New York, USA.
FAU - Varghese, Elizabeth
AU  - Varghese E
FAU - Mahgoub, Nahla
AU  - Mahgoub N
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Am Geriatr Soc
JT  - Journal of the American Geriatrics Society
JID - 7503062
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Antipsychotic Agents)
RN  - L6UH7ZF8HC (Risperidone)
SB  - IM
MH  - Aged, 80 and over
MH  - Antihypertensive Agents/therapeutic use
MH  - Antipsychotic Agents/therapeutic use
MH  - Diagnosis, Differential
MH  - Female
MH  - Geriatric Assessment
MH  - Humans
MH  - Hygiene
MH  - Mental Disorders/*diagnosis/*drug therapy
MH  - Nursing Homes
MH  - Risperidone/therapeutic use
MH  - Social Isolation
MH  - Syndrome
EDAT- 2012/09/19 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/09/19 06:00
PHST- 2012/09/19 06:00 [entrez]
PHST- 2012/09/19 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1111/j.1532-5415.2012.04128.x [doi]
PST - ppublish
SO  - J Am Geriatr Soc. 2012 Sep;60(9):1780-1. doi: 10.1111/j.1532-5415.2012.04128.x.


PMID- 22985122
OWN - NLM
STAT- MEDLINE
DCOM- 20130712
LR  - 20121026
IS  - 1557-8577 (Electronic)
IS  - 1549-1684 (Linking)
VI  - 15
IP  - 5
DP  - 2012 Oct
TI  - Interview with Brian Kennedy, Ph.D. Interview by Vicki Glaser.
PG  - 534-7
LID - 10.1089/rej.2012.1372 [doi]
AB  - Editor's note: The interview series in Rejuvenation Research is a unique and, I
      believe, highly valuable feature of the journal, giving readers insights into the
      thinking and motivation of some of the most influential movers and shakers in the
      many disciplines--not only scientific but also political, sociological, ethical, 
      and more--that impinge on the crusade to defeat aging. Dissemination of the views
      and insights of such people is essential to the process of communication between 
      the field of biomedical gerontology and the many constituencies that will be
      affected by progress against aging--a dialogue that, as I and others have noted
      recently, is essential if we are to develop effective interventions against aging
      with all possible speed.
FAU - Kennedy, Brian
AU  - Kennedy B
LA  - eng
PT  - Interview
PL  - United States
TA  - Rejuvenation Res
JT  - Rejuvenation research
JID - 101213381
SB  - IM
MH  - Aging/*physiology
MH  - Geriatrics
MH  - Humans
MH  - Rejuvenation
EDAT- 2012/09/19 06:00
MHDA- 2013/07/16 06:00
CRDT- 2012/09/19 06:00
PHST- 2012/09/19 06:00 [entrez]
PHST- 2012/09/19 06:00 [pubmed]
PHST- 2013/07/16 06:00 [medline]
AID - 10.1089/rej.2012.1372 [doi]
PST - ppublish
SO  - Rejuvenation Res. 2012 Oct;15(5):534-7. doi: 10.1089/rej.2012.1372.


PMID- 22984977
OWN - NLM
STAT- MEDLINE
DCOM- 20130319
LR  - 20120918
IS  - 1545-5300 (Electronic)
IS  - 0014-7370 (Linking)
VI  - 51
IP  - 3
DP  - 2012 Sep
TI  - The golden pig, reflections as ancestral blessings: the reflecting process in
      teaching family therapy.
PG  - 405-19
LID - 10.1111/j.1545-5300.2012.01405.x [doi]
AB  - This is an example of a postmodern, dialogical approach to teaching family
      therapy based on the work of such practitioners as Tom Andersen, Michael White,
      and Lynn Hoffman, among others. It demonstrates the way in which the reflecting
      process connects all of the participants in a web of meanings both educational
      and transformational. This particular consultation, which includes the author,
      her graduate students, the client, and guest participant Lynn Hoffman, ends with 
      an unexpected ritual of intergenerational appreciation. Privileging the
      transcript, it is presented as a kind of theatre where the learning is revealed
      more through the dialogue than through authorial analysis. The experience is
      embedded in an "ethics of participation" (Hoffman, 1992) where social
      connectedness and attunement are key.
CI  - (c) FPI, Inc.
FAU - Davis, Judith
AU  - Davis J
AD  - Applied Psychology, Antioch University, Keene, NH 03431-3516, USA.
      judavis@acad.umass.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Fam Process
JT  - Family process
JID - 0400666
SB  - IM
MH  - Communication
MH  - Empathy
MH  - Family Therapy/*education
MH  - Humans
MH  - Interviews as Topic
MH  - *Professional-Patient Relations
MH  - Videotape Recording
EDAT- 2012/09/19 06:00
MHDA- 2013/03/21 06:00
CRDT- 2012/09/19 06:00
PHST- 2012/09/19 06:00 [entrez]
PHST- 2012/09/19 06:00 [pubmed]
PHST- 2013/03/21 06:00 [medline]
AID - 10.1111/j.1545-5300.2012.01405.x [doi]
PST - ppublish
SO  - Fam Process. 2012 Sep;51(3):405-19. doi: 10.1111/j.1545-5300.2012.01405.x.


PMID- 22984874
OWN - NLM
STAT- MEDLINE
DCOM- 20130124
LR  - 20120918
IS  - 1557-8070 (Electronic)
IS  - 1557-8070 (Linking)
VI  - 12
IP  - 9
DP  - 2012 Sep
TI  - The Astrobiology in Secondary Classrooms (ASC) curriculum: focusing upon diverse 
      students and teachers.
PG  - 892-9
LID - 10.1089/ast.2012.0841 [doi]
AB  - The Minority Institution Astrobiology Collaborative (MIAC) began working with the
      NASA Goddard Center for Astrobiology in 2003 to develop curriculum materials for 
      high school chemistry and Earth science classes based on astrobiology concepts.
      The Astrobiology in Secondary Classrooms (ASC) modules emphasize
      interdisciplinary connections in astronomy, biology, chemistry, geoscience,
      physics, mathematics, and ethics through hands-on activities that address
      national educational standards. Field-testing of the Astrobiology in Secondary
      Classrooms materials occurred over three years in eight U.S. locations, each with
      populations that are underrepresented in the career fields of science,
      technology, engineering, and mathematics. Analysis of the educational research
      upon the high school students participating in the ASC project showed
      statistically significant increases in students' perceived knowledge and science 
      reasoning. The curriculum is in its final stages, preparing for review to become 
      a NASA educational product.
FAU - Arino de la Rubia, Leigh S
AU  - Arino de la Rubia LS
AD  - Center of Excellence for Learning Sciences, Tennessee State University,
      Nashville, Tennessee 37209, USA. larino@tnstate.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Astrobiology
JT  - Astrobiology
JID - 101088083
SB  - IM
MH  - *Curriculum
MH  - Exobiology/*education
MH  - Humans
MH  - Program Development
MH  - Schools
MH  - Students
MH  - Teaching
MH  - United States
MH  - United States National Aeronautics and Space Administration
EDAT- 2012/09/19 06:00
MHDA- 2013/01/25 06:00
CRDT- 2012/09/19 06:00
PHST- 2012/09/19 06:00 [entrez]
PHST- 2012/09/19 06:00 [pubmed]
PHST- 2013/01/25 06:00 [medline]
AID - 10.1089/ast.2012.0841 [doi]
PST - ppublish
SO  - Astrobiology. 2012 Sep;12(9):892-9. doi: 10.1089/ast.2012.0841.


PMID- 22984818
OWN - NLM
STAT- MEDLINE
DCOM- 20130927
LR  - 20130405
IS  - 1445-2197 (Electronic)
IS  - 1445-1433 (Linking)
VI  - 83
IP  - 4
DP  - 2013 Apr
TI  - Prospective, multicentre, randomized controlled trial of bladder filling prior to
      trial of void on the timing of discharge.
PG  - 239-42
LID - 10.1111/j.1445-2197.2012.06253.x [doi]
AB  - BACKGROUND: The objective of this study was to investigate whether bladder
      filling with saline prior to trial of void (TOV) was safe and whether it reduced 
      time to discharge compared with standard TOV in the urology inpatient setting for
      patients post-transurethral resection of prostate, bladder neck incision or an
      admission with urinary retention. METHODS: Prospective, multicentre, randomized
      controlled trial at Hawkes Bay and Waikato hospitals with local ethics committee 
      approval. All consecutive, consented patients requiring TOV were randomized into 
      filling and control groups. The filling groups were filled with normal saline
      prior to TOV (up to 500 mL or first sensation of fullness). The control group had
      their catheter removed at 06.00 hours without filling. Time taken between
      catheter removal and discharge was recorded in minutes. Complications were
      recorded. RESULTS: Fifty-two patients were recruited and randomized with 27 and
      25 patients in the filling and control groups, respectively. The mean time taken 
      from catheter removal to discharge was 300.6 min in the filling group and 340.1
      min in the control group. The filling group reduced the time to discharge by 39.5
      min (P = 0.304). Furthermore, 2/27 and 2/25 patients in the filling and control
      groups, respectively, developed urinary retention after TOV and required
      re-catheterization prior to discharge. CONCLUSION: Bladder filling prior to TOV
      showed a non-statistically significant reduction in the time to discharge of 39.5
      min. Despite the fact that bladder filling is a safe and cheap procedure, it
      cannot be recommended for use in an attempt to reduce time to discharge in an
      inpatient setting.
CI  - (c) 2012 The Authors. ANZ Journal of Surgery (c) 2012 Royal Australasian College 
      of Surgeons.
FAU - Du, Jason
AU  - Du J
AD  - Department of Urology, Hawkes Bay Hospital, Omahu Road, Hastings 4120, New
      Zealand. tojasondu@gmail.com
FAU - Marshall, Daniel
AU  - Marshall D
FAU - Leyland, John
AU  - Leyland J
FAU - Shaw, Leanne
AU  - Shaw L
FAU - Broome, Kim E
AU  - Broome KE
FAU - Mason, David F C
AU  - Mason DF
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
DEP - 20120918
PL  - Australia
TA  - ANZ J Surg
JT  - ANZ journal of surgery
JID - 101086634
RN  - 0 (Saline Solution, Hypertonic)
SB  - IM
CIN - ANZ J Surg. 2013 Jul;83(7-8):591. PMID: 23890306
MH  - Aged
MH  - Aged, 80 and over
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Prostatic Hyperplasia/*physiopathology/*surgery
MH  - Saline Solution, Hypertonic/*administration & dosage
MH  - Time Factors
MH  - Transurethral Resection of Prostate
MH  - Urinary Catheterization
MH  - Urinary Retention/*physiopathology
MH  - Urination/physiology
EDAT- 2012/09/19 06:00
MHDA- 2013/09/28 06:00
CRDT- 2012/09/19 06:00
PHST- 2012/08/08 00:00 [accepted]
PHST- 2012/09/19 06:00 [entrez]
PHST- 2012/09/19 06:00 [pubmed]
PHST- 2013/09/28 06:00 [medline]
AID - 10.1111/j.1445-2197.2012.06253.x [doi]
PST - ppublish
SO  - ANZ J Surg. 2013 Apr;83(4):239-42. doi: 10.1111/j.1445-2197.2012.06253.x. Epub
      2012 Sep 18.


PMID- 22984728
OWN - NLM
STAT- MEDLINE
DCOM- 20121010
LR  - 20120918
IS  - 0022-0892 (Print)
IS  - 0022-0892 (Linking)
VI  - 75
IP  - 2
DP  - 2012 Sep
TI  - Ethics and integrity: capstone professional tools.
PG  - 4-5
FAU - Collins, Brian
AU  - Collins B
AD  - brianc@plano.gov
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Environ Health
JT  - Journal of environmental health
JID - 0405525
SB  - IM
MH  - Environmental Health/*ethics
MH  - *Ethics, Professional
MH  - Humans
MH  - United States
EDAT- 2012/09/19 06:00
MHDA- 2012/10/12 06:00
CRDT- 2012/09/19 06:00
PHST- 2012/09/19 06:00 [entrez]
PHST- 2012/09/19 06:00 [pubmed]
PHST- 2012/10/12 06:00 [medline]
PST - ppublish
SO  - J Environ Health. 2012 Sep;75(2):4-5.


PMID- 22984372
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120918
LR  - 20211021
IS  - 1861-8863 (Electronic)
IS  - 1861-8863 (Linking)
VI  - 8
DP  - 2012
TI  - Therapy of the burnout syndrome.
PG  - Doc05
LID - 10.3205/hta000103 [doi]
AB  - BACKGROUND: The prevalence, diagnostics and therapy of the burnout syndrome are
      increasingly discussed in the public. The unclear definition and diagnostics of
      the burnout syndrome are scientifically criticized. There are several therapies
      with unclear evidence for the treatment of burnout in existence. OBJECTIVES: The 
      health technology assessment (HTA) report deals with the question of usage and
      efficacy of different burnout therapies. METHODS: For the years 2006 to 2011, a
      systematic literature research was done in 31 electronic databases (e.g. EMBASE, 
      MEDLINE, PsycINFO). Important inclusion criteria are burnout, therapeutic
      intervention and treatment outcome. RESULTS: 17 studies meet the inclusion
      criteria and are regarded for the HTA report. The studies are very heterogeneous 
      (sample size, type of intervention, measuring method, level of evidence). Due to 
      their study design (e.g. four reviews, eight randomized controlled trials) the
      studies have a comparable high evidence: three times 1A, five times 1B, one time 
      2A, two times 2B and six times 4. 13 of the 17 studies are dealing with the
      efficacy of psychotherapy and psychosocial interventions for the reduction of
      burnout (partly in combination with other techniques). Cognitive behaviour
      therapy leads to the improvement of emotional exhaustion in the majority of the
      studies. The evidence is inconsistent for the efficacy of stress management and
      music therapy. Two studies regarding the efficacy of Qigong therapy do not
      deliver a distinct result. One study proves the efficacy of roots of Rhodiola
      rosea (evidence level 1B). Physical therapy is only in one study separately
      examined and does not show a better result than standard therapy. DISCUSSION:
      Despite the number of studies with high evidence the results for the efficacy of 
      burnout therapies are preliminary and do have only limited reach. The authors of 
      the studies complain about the low number of skilled studies for the therapy of
      burnout. Furthermore, they point to the insufficient evaluation of the therapy
      studies and the need for further research. Some authors report the effects of
      considerable natural recovering. Numerous limitations affect the quality of the
      results. Intervention contents and duration, study design and study size are very
      diverse and do not permit direct comparison. Most of the samples are small by
      size with low statistical power, long-term follow-ups are missing. Comorbidities 
      and parallel utilized therapies are insufficient documented or controlled. Most
      of the studies use the Maslach Burnout Inventory (MBI) as diagnostic or
      outcome-tool, but with different cut-off-points. It should be noticed that the
      validity of the MBI as diagnostic tool is not proved. Ethical, juridical and
      social determining factors are not covered or discussed in the studies.
      CONCLUSION: The efficacy of therapies for the treatment of the burnout syndrome
      is insufficient investigated. Only for cognitive behavioural therapy (CBT) exists
      an adequate number of studies which prove its efficacy. Big long-term
      experimental studies are missing which compare the efficacy of the single
      therapies and evaluate their evidence. The natural recovering without any therapy
      needs further research. Additionally, it has to be examined to what extent
      therapies and their possible effects are thwarted by the conditions of the
      working place and the working conditions.
FAU - Korczak, Dieter
AU  - Korczak D
AD  - GP Forschungsgruppe, Institut fur Grundlagen- und Programmforschung, Munchen,
      Germany.
FAU - Wastian, Monika
AU  - Wastian M
FAU - Schneider, Michael
AU  - Schneider M
LA  - eng
PT  - Journal Article
DEP - 20120614
PL  - Germany
TA  - GMS Health Technol Assess
JT  - GMS health technology assessment
JID - 101276045
PMC - PMC3434360
OTO - NOTNLM
OT  - CBT
OT  - EBM
OT  - HTA
OT  - HTA report
OT  - HTA-report
OT  - TA
OT  - burnout
OT  - burnout intervention study
OT  - burnout, professional
OT  - cognitive behavior therapy
OT  - cognitive behavior treatment
OT  - cognitive behaviour therapy
OT  - cognitive behaviour treatment
OT  - cognitive therapy
OT  - cognitive-behavioral therapy
OT  - cognitive-behavioral treatment
OT  - cognitive-behavioural therapy
OT  - cognitive-behavioural treatment
OT  - depression
OT  - depressive disorder
OT  - evidence based medicine
OT  - evidence-based medicine
OT  - health technology assessment
OT  - humans
OT  - individual-focused intervention
OT  - mind-body therapies
OT  - mind-body therapy
OT  - music therapy
OT  - person-directed intervention
OT  - phytotherapy
OT  - prognostic instrument
OT  - psychotherapy
OT  - qigong
OT  - relaxation
OT  - review
OT  - review literature
OT  - review literature as topic
OT  - rhodiola
OT  - rhodiola rosea
OT  - stress management training
OT  - systematic review
OT  - technology assessment
OT  - technology assessment, biomedical
OT  - therapeutics
OT  - therapy
OT  - treatment
OT  - treatment outcome
EDAT- 2012/09/18 06:00
MHDA- 2012/09/18 06:01
CRDT- 2012/09/18 06:00
PHST- 2012/09/18 06:00 [entrez]
PHST- 2012/09/18 06:00 [pubmed]
PHST- 2012/09/18 06:01 [medline]
AID - 10.3205/hta000103 [doi]
AID - hta000103 [pii]
PST - ppublish
SO  - GMS Health Technol Assess. 2012;8:Doc05. doi: 10.3205/hta000103. Epub 2012 Jun
      14.


PMID- 22984371
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120918
LR  - 20211021
IS  - 1861-8863 (Electronic)
IS  - 1861-8863 (Linking)
VI  - 8
DP  - 2012
TI  - Bone graft substitutes for the treatment of traumatic fractures of the
      extremities.
PG  - Doc04
LID - 10.3205/hta000102 [doi]
AB  - UNLABELLED: HEALTH POLITICAL AND SCIENTIFIC BACKGROUND: Bone graft substitutes
      are increasingly being used as supplements to standard care or as alternative to 
      bone grafts in the treatment of traumatic fractures. RESEARCH QUESTIONS: The
      efficacy and cost-effectiveness of bone graft substitutes for the treatment of
      traumatic fractures as well as the ethical, social and legal implications of
      their use are the main research questions addressed. METHODS: A systematic
      literature search was conducted in electronic medical databases (MEDLINE, EMBASE 
      etc.) in December 2009. Randomised controlled trials (RCT), where applicable also
      containing relevant health economic evaluations and publications addressing the
      ethical, social and legal aspects of using bone graft substitutes for fracture
      treatment were included in the analysis. After assessment of study quality the
      information synthesis of the medical data was performed using metaanalysis, the
      synthesis of the health economic data was performed descriptively. RESULTS: 14
      RCT were included in the medical analysis, and two in the heath economic
      evaluation. No relevant publications on the ethical, social and legal
      implications of the bone graft substitute use were found. In the RCT on fracture 
      treatment with bone morphogenetic protein-2 (BMP-2) versus standard care without 
      bone grafting (RCT with an elevated high risk of bias) there was a significant
      difference in favour of BMP-2 for several outcome measures. The RCT of calcium
      phosphate (CaP) cement and bone marrow-based composite materials versus
      autogenous bone grafts (RCT with a high risk of bias) revealed significant
      differences in favour of bone graft substitutes for some outcome measures.
      Regarding the other bone graft substitutes, almost all comparisons demonstrated
      no significant difference. The use of BMP-2 in addition to standard care without 
      bone grafting led in the study to increased treatment costs considering all
      patients with traumatic open fractures. However, cost savings through the
      additional use of BMP-2 were calculated in a patient subgroup with high-grade
      open fractures (Gustilo-Anderson grade IIIB). Cost-effectiveness for BMP-2 versus
      standard care with autologous bone grafts as well as for other bone graft
      substitutes in fracture treatment has not been determined yet. DISCUSSION:
      Although there were some significant differences in favour of BMP-2, due to the
      overall poor quality of the studies the evidence can only be interpreted as
      suggestive for efficacy. In the case of CaP cements and bone marrow-based bone
      substitute materials, the evidence is only weakly suggestive for efficacy. From
      an overall economic perspective, the transferability of the results of the health
      economic evaluations to the current situation in Germany is limited. CONCLUSIONS:
      The current evidence is insufficient to evaluate entirely the use of different
      bone graft substitutes for fracture treatment. From a medical point of view,
      BMP-2 is a viable alternative for treatment of open fractures of the tibia,
      especially in cases where bone grafting is not possible. Autologous bone grafting
      is preferable comparing to the use of OP-1. Possible advantages of CaP cements
      and composites containing bone marrow over autogenous bone grafting should be
      taken into account in clinical decision making. The use of the hydroxyapatite
      material and allograft bone chips compared to autologous bone grafts cannot be
      recommended. From a health economic perspective, the use of BMP-2 in addition to 
      standard care without bone grafting is recommended as cost-saving in patients
      with high-grade open fractures (Gustilo-Anderson grade IIIB). Based on the
      current evidence no further recommendations can be made regarding the use of bone
      graft substitutes for the treatment of fractures. To avoid legal implications,
      use of bone graft substitutes outside their approved indications should be
      avoided.
FAU - Hagen, Anja
AU  - Hagen A
AD  - Institute for Epidemiology, Social Medicine and Health Systems Research, Hannover
      Medical School, Hannover, Germany.
FAU - Gorenoi, Vitali
AU  - Gorenoi V
FAU - Schonermark, Matthias P
AU  - Schonermark MP
LA  - eng
PT  - Journal Article
DEP - 20120614
PL  - Germany
TA  - GMS Health Technol Assess
JT  - GMS health technology assessment
JID - 101276045
PMC - PMC3434359
OTO - NOTNLM
OT  - CCT
OT  - CT
OT  - EBM
OT  - HTA
OT  - HTA report
OT  - HTA-report
OT  - RCT
OT  - TA
OT  - academic review
OT  - accident
OT  - accuracy study
OT  - assessment
OT  - blinded
OT  - blinded study
OT  - blinded trial
OT  - blinding
OT  - bone and bones
OT  - bone fracture
OT  - bone graft
OT  - bone substitutes
OT  - bone substitutes/economics
OT  - bone substitutes/therapeutic use
OT  - bone transplantation
OT  - clinical study
OT  - clinical trial
OT  - clinical trials as topic
OT  - controlled clinical study
OT  - controlled clinical trial
OT  - controlled clinical trials as topic
OT  - cost analysis
OT  - cost control
OT  - cost effectiveness
OT  - cost minimisation
OT  - cost minimization
OT  - cost reduction
OT  - cost-benefit analysis
OT  - cost-cutting
OT  - cost-effectiveness
OT  - costs
OT  - costs and cost analysis
OT  - cross-over studies
OT  - decision making
OT  - economic aspect
OT  - economic model
OT  - economics
OT  - economics, medical
OT  - effectiveness
OT  - efficiency
OT  - ethics
OT  - evaluation
OT  - evaluation studies as topic
OT  - evaluation study
OT  - evidence based medicine
OT  - evidence-based medicine
OT  - fracture
OT  - fractures, bone
OT  - health
OT  - health economic study
OT  - health economics
OT  - health funding
OT  - health policy
OT  - health technology assessment
OT  - humans
OT  - judgment
OT  - medical assessment
OT  - medical costs
OT  - medical economics
OT  - medical efficacy
OT  - medical evaluation
OT  - medical laboratory science
OT  - medical technology
OT  - meta analysis
OT  - meta-analysis
OT  - meta-analysis as topic
OT  - models, economic
OT  - multicenter studies as topic
OT  - multicenter study
OT  - peer review
OT  - pharmacoeconomics
OT  - placebo
OT  - placebo effect
OT  - placebos
OT  - prospective studies
OT  - random
OT  - random allocation
OT  - randomisation
OT  - randomised clinical study
OT  - randomised clinical trial
OT  - randomised controlled trial
OT  - randomised study
OT  - randomised trial
OT  - randomization
OT  - randomized clinical study
OT  - randomized clinical trial
OT  - randomized controlled trial
OT  - randomized controlled trials as topic
OT  - randomized study
OT  - randomized trial
OT  - report
OT  - research article
OT  - research-article
OT  - review
OT  - review literature
OT  - review literature as topic
OT  - risk assessment
OT  - sensitivity
OT  - sensitivity and specificity
OT  - sickness costs
OT  - social economic factor
OT  - socioeconomic factor
OT  - socioeconomic factors
OT  - socioeconomics
OT  - specifity
OT  - systematic review
OT  - technical report
OT  - technology
OT  - technology assessment
OT  - technology assessment, biomedical
OT  - technology evaluation
OT  - traumatology
OT  - validation studies as topic
OT  - validation study
EDAT- 2012/09/18 06:00
MHDA- 2012/09/18 06:01
CRDT- 2012/09/18 06:00
PHST- 2012/09/18 06:00 [entrez]
PHST- 2012/09/18 06:00 [pubmed]
PHST- 2012/09/18 06:01 [medline]
AID - 10.3205/hta000102 [doi]
AID - hta000102 [pii]
PST - ppublish
SO  - GMS Health Technol Assess. 2012;8:Doc04. doi: 10.3205/hta000102. Epub 2012 Jun
      14.


PMID- 22984365
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1741-0541 (Print)
IS  - 1741-0541 (Linking)
VI  - 9
IP  - 4
DP  - 2012 Jun
TI  - Population-based screening in the era of genomics.
PG  - 451-455
AB  - To date, risk profiles based on the known common susceptibility variants have
      limited value in predicting risk of disease but they could be used for risk
      stratification in prevention programmes at population level. We illustrate the
      potential utility of polygenic risk stratification using the case of
      population-based screening for prostate and breast cancer. We compared the number
      of individuals eligible for screening and the number of cases potentially
      detectable by screening in a population undergoing screening based on age alone
      with a population undergoing stratified screening based on age and polygenic risk
      profile. Stratified screening strategy based on age and genetic risk would
      potentially improve the efficiency of screening programmes and reduce their
      adverse consequences. Organisational, ethical, legal and social issues need to be
      addressed before stratified screening programmes could be implemented.
FAU - Pashayan, Nora
AU  - Pashayan N
AD  - University College London, Centre of Applied Health Research, 1-19 Torrington
      Place, London WC1E 6BT.
FAU - Pharoah, Paul
AU  - Pharoah P
LA  - eng
GR  - 13065/CRUK_/Cancer Research UK/United Kingdom
GR  - A10119/CRUK_/Cancer Research UK/United Kingdom
GR  - A13065/CRUK_/Cancer Research UK/United Kingdom
PT  - Journal Article
PL  - England
TA  - Per Med
JT  - Personalized medicine
JID - 101238549
PMC - PMC3442228
MID - UKMS48908
EDAT- 2012/09/18 06:00
MHDA- 2012/09/18 06:01
CRDT- 2012/09/18 06:00
PHST- 2012/09/18 06:00 [entrez]
PHST- 2012/09/18 06:00 [pubmed]
PHST- 2012/09/18 06:01 [medline]
AID - 10.2217/pme.12.40 [doi]
PST - ppublish
SO  - Per Med. 2012 Jun;9(4):451-455. doi: 10.2217/pme.12.40.


PMID- 22983877
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 5
DP  - 2012
TI  - The Northern Manhattan Caregiver Intervention Project: a randomised trial testing
      the effectiveness of a dementia caregiver intervention in Hispanics in New York
      City.
LID - 10.1136/bmjopen-2012-001941 [doi]
LID - e001941 [pii]
AB  - OBJECTIVES: Dementia prevalence and its burden on families are increasing.
      Caregivers of persons with dementia have more depression and stress than the
      general population. Several interventions have proven efficacy in decreasing
      depression and stress in selected populations of caregivers. Hispanics in New
      York City tend to have a higher burden of dementia caregiving compared to
      non-Hispanic whites (NHW) because Hispanics have a higher prevalence of dementia,
      tend to have high family involvement, and tend to have higher psychosocial and
      economic stressors. Thus, we chose to test the effectiveness of a dementia
      caregiving intervention, the New York University Caregiver Intervention (NYUCI), 
      with demonstrated efficacy in spouse caregivers in Hispanic relative caregivers
      of persons with dementia. Including the community health worker (CHW)
      intervention in both arms alleviates general psychosocial stressors and allows
      the assessment of the effectiveness of the intervention. Compared to two original
      efficacy studies of the NYUCI, which included only spouse caregivers, our study
      includes all relative caregivers, including common law spouses, children,
      siblings, a nephew and nieces. This study will be the first randomised trial to
      test the effectiveness of the NYUCI in Hispanic caregivers including non-spouses.
      METHODS AND ANALYSIS: The design of the study is a randomised controlled trial
      (RCT). Participants are randomised to two arms: case management by a CHW and an
      intervention arm including the NYUCI in addition to case management by the CHW.
      The duration of intervention is 6 months. The main outcomes in the trial are
      changes in the Geriatric Depression Scale (GDS) and the Zarit Caregiver Burden
      Scale (ZCBS) from baseline to 6 months. ETHICS AND DISSEMINATION: This trial is
      approved by the Columbia University Medical Center Institutional Review Board
      (AAAI0022), and funded by the National Institute on Minority Health and Health
      Disparities. The funding agency has no role in dissemination. TRIAL REGISTRATION:
      www.ClinicalTrials.gov NCT01306695.
FAU - Luchsinger, Jose
AU  - Luchsinger J
AD  - Departments of Medicine and Epidemiology, Columbia University Medical Center, New
      York, New York, USA.
FAU - Mittelman, Mary
AU  - Mittelman M
FAU - Mejia, Miriam
AU  - Mejia M
FAU - Silver, Stephanie
AU  - Silver S
FAU - Lucero, Robert J
AU  - Lucero RJ
FAU - Ramirez, Mildred
AU  - Ramirez M
FAU - Kong, Jian
AU  - Kong J
FAU - Teresi, Jeanne A
AU  - Teresi JA
LA  - eng
SI  - ClinicalTrials.gov/NCT01306695
GR  - P30 AG008051/AG/NIA NIH HHS/United States
GR  - P60 MD000206/MD/NIMHD NIH HHS/United States
GR  - UL1 RR024156/RR/NCRR NIH HHS/United States
PT  - Journal Article
DEP - 20120914
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3467593
EDAT- 2012/09/18 06:00
MHDA- 2012/09/18 06:01
CRDT- 2012/09/18 06:00
PHST- 2012/09/18 06:00 [entrez]
PHST- 2012/09/18 06:00 [pubmed]
PHST- 2012/09/18 06:01 [medline]
AID - bmjopen-2012-001941 [pii]
AID - 10.1136/bmjopen-2012-001941 [doi]
PST - epublish
SO  - BMJ Open. 2012 Sep 14;2(5). pii: bmjopen-2012-001941. doi:
      10.1136/bmjopen-2012-001941. Print 2012.


PMID- 22983782
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 5
DP  - 2012
TI  - Early rehabilitation in critical care (eRiCC): functional electrical stimulation 
      with cycling protocol for a randomised controlled trial.
LID - 10.1136/bmjopen-2012-001891 [doi]
LID - e001891 [pii]
AB  - INTRODUCTION: Intensive care-acquired weakness is a common problem, leads to
      significant impairment in physical functioning and muscle strength, and is
      prevalent in individuals with sepsis. Early rehabilitation has been shown to be
      safe and feasible; however, commencement is often delayed due to a patient's
      inability to co-operate. An intervention that begins early in an intensive care
      unit (ICU) admission without the need for patient volition may be beneficial in
      attenuating muscle wasting. The eRiCC (early rehabilitation in critical care)
      trial will investigate the effectiveness of functional electrical
      stimulation-assisted cycling and cycling alone, compared to standard care, in
      individuals with sepsis. METHODS AND ANALYSIS: This is a single centre randomised
      controlled trial. Participants (n=80) aged >/=18 years, with a diagnosis of
      sepsis or severe sepsis, who are expected to be mechanically ventilated for >/=48
      h and remain in the intensive care >/=4 days will be randomised within 72 h of
      admission to (1) standard care or (2) intervention where participants will
      receive functional electrical muscle stimulation-assisted supine cycling on one
      leg while the other leg undergoes cycling alone. Primary outcome measures
      include: muscle mass (quadriceps ultrasonography; bioelectrical impedance
      spectroscopy); muscle strength (Medical Research Council Scale; hand-held
      dynamometry) and physical function (Physical Function in Intensive Care Test;
      Functional Status Score in intensive care; 6 min walk test). Blinded outcome
      assessors will assess measures at baseline, weekly, at ICU discharge and acute
      hospital discharge. Secondary measures will be evaluated in a nested subgroup
      (n=20) and will consist of biochemical/histological analyses of collected muscle,
      urine and blood samples at baseline and at ICU discharge. ETHICS AND
      DISSEMINATION: Ethics approval has been obtained from the relevant institution,
      and results will be published to inform clinical practice in the care of patients
      with sepsis to optimise rehabilitation and physical function outcomes. TRIAL
      REGISTRATION: Australian and New Zealand Clinical Trials Registry
      ACTRN12612000528853.
FAU - Parry, Selina M
AU  - Parry SM
AD  - Department of Physiotherapy, School of Health Sciences, The University of
      Melbourne, Melbourne, Australia.
FAU - Berney, Sue
AU  - Berney S
FAU - Koopman, Rene
AU  - Koopman R
FAU - Bryant, Adam
AU  - Bryant A
FAU - El-Ansary, Doa
AU  - El-Ansary D
FAU - Puthucheary, Zudin
AU  - Puthucheary Z
FAU - Hart, Nicholas
AU  - Hart N
FAU - Warrillow, Stephen
AU  - Warrillow S
FAU - Denehy, Linda
AU  - Denehy L
LA  - eng
PT  - Journal Article
DEP - 20120913
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3467594
EDAT- 2012/09/18 06:00
MHDA- 2012/09/18 06:01
CRDT- 2012/09/18 06:00
PHST- 2012/09/18 06:00 [entrez]
PHST- 2012/09/18 06:00 [pubmed]
PHST- 2012/09/18 06:01 [medline]
AID - bmjopen-2012-001891 [pii]
AID - 10.1136/bmjopen-2012-001891 [doi]
PST - epublish
SO  - BMJ Open. 2012 Sep 13;2(5). pii: bmjopen-2012-001891. doi:
      10.1136/bmjopen-2012-001891. Print 2012.


PMID- 22983293
OWN - NLM
STAT- MEDLINE
DCOM- 20121207
LR  - 20220530
IS  - 1678-9946 (Electronic)
IS  - 0036-4665 (Linking)
VI  - 54
IP  - 5
DP  - 2012 Sep-Oct
TI  - Genetic control of mosquitoes: population suppression strategies.
PG  - 287-92
LID - S0036-46652012000500009 [pii]
AB  - Over the last two decades, morbidity and mortality from malaria and dengue fever 
      among other pathogens are an increasing Public Health problem. The increase in
      the geographic distribution of vectors is accompanied by the emergence of viruses
      and diseases in new areas. There are insufficient specific therapeutic drugs
      available and there are no reliable vaccines for malaria or dengue, although some
      progress has been achieved, there is still a long way between its development and
      actual field use. Most mosquito control measures have failed to achieve their
      goals, mostly because of the mosquito's great reproductive capacity and genomic
      flexibility. Chemical control is increasingly restricted due to potential human
      toxicity, mortality in no target organisms, insecticide resistance, and other
      environmental impacts. Other strategies for mosquito control are desperately
      needed. The Sterile Insect Technique (SIT) is a species-specific and
      environmentally benign method for insect population suppression, it is based on
      mass rearing, radiation mediated sterilization, and release of a large number of 
      male insects. Releasing of Insects carrying a dominant lethal gene (RIDL) offers 
      a solution to many of the drawbacks of traditional SIT that have limited its
      application in mosquitoes while maintaining its environmentally friendly and
      species-specific utility. The self-limiting nature of sterile mosquitoes tends to
      make the issues related to field use of these somewhat less challenging than for 
      self-spreading systems characteristic of population replacement strategies. They 
      also are closer to field use, so might be appropriate to consider first. The
      prospect of genetic control methods against mosquito vectored human diseases is
      rapidly becoming a reality, many decisions will need to be made on a national,
      regional and international level regarding the biosafety, social, cultural and
      ethical aspects of the use and deployment of these vector control methods.
FAU - Wilke, Andre Barretto Bruno
AU  - Wilke AB
AD  - Department of Epidemiology, University of Sao Paulo, Sao Paulo, SP, Brazil.
FAU - Marrelli, Mauro Toledo
AU  - Marrelli MT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Brazil
TA  - Rev Inst Med Trop Sao Paulo
JT  - Revista do Instituto de Medicina Tropical de Sao Paulo
JID - 7507484
SB  - IM
MH  - Animals
MH  - Culicidae/*genetics/physiology
MH  - Female
MH  - Genes, Lethal/*genetics
MH  - Insect Vectors/*genetics/physiology
MH  - Male
MH  - Mosquito Control/*methods
EDAT- 2012/09/18 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/09/18 06:00
PHST- 2011/10/31 00:00 [received]
PHST- 2012/05/17 00:00 [accepted]
PHST- 2012/09/18 06:00 [entrez]
PHST- 2012/09/18 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - S0036-46652012000500009 [pii]
AID - 10.1590/s0036-46652012000500009 [doi]
PST - ppublish
SO  - Rev Inst Med Trop Sao Paulo. 2012 Sep-Oct;54(5):287-92. doi:
      10.1590/s0036-46652012000500009.


PMID- 22982801
OWN - NLM
STAT- MEDLINE
DCOM- 20130613
LR  - 20210204
IS  - 1934-2403 (Electronic)
IS  - 1530-891X (Linking)
VI  - 18
IP  - 6
DP  - 2012 Nov-Dec
TI  - Association of Clinical Researchers and Educators a statement on relationships
      between physicians and industry.
PG  - 1029-37
LID - 10.4158/EP12163.CO [doi]
AB  - Collaborations between physicians, particularly those in academic medicine, and
      industries that develop pharmaceutical products, medical devices, and diagnostic 
      tests have led to substantial advances in patient care. At the same time, there
      is a strong awareness that these relationships, however beneficial they may be,
      should conform to established principles of ethical professional practice.
      Through a writing committee drawn from diverse disciplines across several
      institutions, the Association of Clinical Researchers and Educators (ACRE) has
      written a code of conduct to provide guidance to physicians in observing these
      principles. Our recommendations are not intended to be prescriptive or
      inflexible, but rather to be of assistance to physicians in making their own
      personal decisions on whether, or how, to be involved in research, education, or 
      other collaborations with industry.
FAU - Weber, Michael A
AU  - Weber MA
AD  - State University of New York, Downstate College of Medicine, Brooklyn, New York, 
      112013, USA. michaelwebermd@cs.com
FAU - Black, Henry R
AU  - Black HR
FAU - Fonseca, Rafael
AU  - Fonseca R
FAU - Garber, Jeffrey
AU  - Garber J
FAU - Gonzalez-Campoy, J Michael
AU  - Gonzalez-Campoy JM
FAU - Kimmelstiel, Carey
AU  - Kimmelstiel C
FAU - Markowitz, Avi B
AU  - Markowitz AB
FAU - Nakayama, Don
AU  - Nakayama D
FAU - Stell, Lance K
AU  - Stell LK
FAU - Stossel, Thomas P
AU  - Stossel TP
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Endocr Pract
JT  - Endocrine practice : official journal of the American College of Endocrinology
      and the American Association of Clinical Endocrinologists
JID - 9607439
SB  - IM
CIN - Endocr Pract. 2013 Mar-Apr;19(2):378-9. PMID: 23337166
CIN - Endocr Pract. 2013 Mar-Apr;19(2):379-80. PMID: 23512399
CIN - Endocr Pract. 2013 Mar-Apr;19(2):380. PMID: 23738372
CIN - Endocr Pract. 2013 Mar-Apr;19(2):380-1. PMID: 23738373
MH  - Codes of Ethics
MH  - Education, Medical, Continuing/ethics
MH  - *Ethics, Professional
MH  - Health Care Sector/*ethics
MH  - Humans
MH  - Interprofessional Relations/*ethics
MH  - Physicians/*ethics
MH  - Publishing/ethics
MH  - Research Personnel/ethics
EDAT- 2012/09/18 06:00
MHDA- 2013/06/14 06:00
CRDT- 2012/09/18 06:00
PHST- 2012/09/18 06:00 [entrez]
PHST- 2012/09/18 06:00 [pubmed]
PHST- 2013/06/14 06:00 [medline]
AID - S1530-891X(20)43028-9 [pii]
AID - 10.4158/EP12163.CO [doi]
PST - ppublish
SO  - Endocr Pract. 2012 Nov-Dec;18(6):1029-37. doi: 10.4158/EP12163.CO.


PMID- 22982491
OWN - NLM
STAT- MEDLINE
DCOM- 20130304
LR  - 20151119
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 1
DP  - 2013 Jan
TI  - Willingness to treat infectious diseases: what do students think?
PG  - 22-6
LID - 10.1136/medethics-2012-100509 [doi]
AB  - INTRODUCTION: Outbreaks of serious communicable infectious diseases remain a
      major global medical problem and force healthcare workers to make hard choices
      with limited information, resources and time. While information regarding
      physicians' opinions about such dilemmas is available, research discussing
      students' opinions is more limited. METHODS: Medical students were surveyed about
      their willingness to perform medical procedures on patients with communicable
      diseases as students and as physicians. Students were asked about their opinions 
      regarding the duty to treat in such cases. RESULTS: 74% of respondents felt that 
      by deciding to enter medical school they were morally obliged to treat any
      patient despite the risks. Students' willingness to treat as physicians is
      significantly higher than their willingness to treat as students. HIV was
      significantly the most tolerated disease with respect to performing mouth to
      mouth resuscitation. Among preclinical students, we found that willingness to
      treat during the later years is significantly greater than during the earlier
      years. Among clinical students, the opposite was observed. DISCUSSION: Students' 
      greater willingness to treat as physicians is mostly attributed to perceptions of
      higher obligations as a qualified doctor. There is greater but not total
      willingness to perform resuscitation on patients with HIV relative to other
      diseases. The increased willingness of preclinical students and the decreased
      willingness of clinical students both emphasise the importance of
      patient-physician communication and ethics studies during medical school.
FAU - Milikovsky, Dan Zeharia
AU  - Milikovsky DZ
AD  - Prywes Center for Medical Education, Faculty of Health Sciences, Ben Gurion
      University of the Negev, Beer-Sheva, Israel.
FAU - Ben Yona, Renana
AU  - Ben Yona R
FAU - Akselrod, Dikla
AU  - Akselrod D
FAU - Glick, Shimon M
AU  - Glick SM
FAU - Jotkowitz, Alan
AU  - Jotkowitz A
LA  - eng
PT  - Journal Article
DEP - 20120914
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Cardiopulmonary Resuscitation/ethics
MH  - *Communicable Diseases
MH  - Education, Medical, Graduate
MH  - Education, Medical, Undergraduate
MH  - Empathy/ethics
MH  - HIV Infections
MH  - Humans
MH  - Israel
MH  - *Moral Obligations
MH  - Refusal to Treat/ethics/*statistics & numerical data
MH  - Statistics, Nonparametric
MH  - Students, Medical/psychology/*statistics & numerical data
MH  - Surgical Procedures, Operative/ethics
MH  - Surveys and Questionnaires
EDAT- 2012/09/18 06:00
MHDA- 2013/03/05 06:00
CRDT- 2012/09/18 06:00
PHST- 2012/09/18 06:00 [entrez]
PHST- 2012/09/18 06:00 [pubmed]
PHST- 2013/03/05 06:00 [medline]
AID - medethics-2012-100509 [pii]
AID - 10.1136/medethics-2012-100509 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Jan;39(1):22-6. doi: 10.1136/medethics-2012-100509. Epub 2012 
      Sep 14.


PMID- 22981776
OWN - NLM
STAT- MEDLINE
DCOM- 20131210
LR  - 20151119
IS  - 1872-6054 (Electronic)
IS  - 0168-8510 (Linking)
VI  - 109
IP  - 1
DP  - 2013 Jan
TI  - Ethics for end-of-life treatments: metastatic colorectal cancer is one example.
PG  - 97-103
LID - 10.1016/j.healthpol.2012.08.017 [doi]
LID - S0168-8510(12)00226-6 [pii]
AB  - The number of biological agents (BAs) registered with an indication related to
      cancer treatment is flourishing and the cost of these treatments is rising
      dramatically, making the situation potentially unsustainable for healthcare
      systems. Here we focus on the examples of bevacizumab (BV) and cetuximab (CX),
      two BAs approved for metastatic colorectal cancer (mCRC). The first clinical
      trials show an increase in median overall survival of a few months, though these 
      results could not always be repeated in subsequent studies. We reviewed full
      economic evaluations (FEEs) on BV or CX and despite frequently arguable estimates
      based on indirect efficacy, only one estimated the addition of CX was
      cost-effective in a virtual subgroup of patients, albeit with flawed methods.
      Most Western European countries reimburse BV and CX for mCRC, though clinical
      evidence seems weak and economic evidence even absent. The underlying question is
      whether national health authorities are prepared to spend an increasing share of 
      healthcare budgets on very expensive end-of-life treatments, their impact on life
      expectancy (a few additional months at best) and QoL (enhanced mainly by
      patients' hopes) being doubtful and their cost-effectiveness hardly ever proved. 
      Further research is needed to explore how ethics could be included and thus
      assessed under these circumstances.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Garattini, Livio
AU  - Garattini L
AD  - CESAV, Center for Health Economics, 'Mario Negri' Institute for Pharmacological
      Research, Ranica, Italy. lgarattini@marionegri.it
FAU - van de Vooren, Katelijne
AU  - van de Vooren K
FAU - Zaniboni, Alberto
AU  - Zaniboni A
LA  - eng
PT  - Journal Article
DEP - 20120914
PL  - Ireland
TA  - Health Policy
JT  - Health policy (Amsterdam, Netherlands)
JID - 8409431
RN  - 0 (Angiogenesis Inhibitors)
RN  - 0 (Antibodies, Monoclonal, Humanized)
RN  - 2S9ZZM9Q9V (Bevacizumab)
RN  - PQX0D8J21J (Cetuximab)
MH  - Angiogenesis Inhibitors/economics/*therapeutic use
MH  - Antibodies, Monoclonal, Humanized/economics/*therapeutic use
MH  - Bevacizumab
MH  - Cetuximab
MH  - Colorectal Neoplasms/*drug therapy/economics
MH  - Cost-Benefit Analysis
MH  - Drug Costs
MH  - Humans
MH  - Neoplasm Metastasis/drug therapy
MH  - Terminal Care/economics/*ethics/methods
MH  - Treatment Outcome
EDAT- 2012/09/18 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/09/18 06:00
PHST- 2012/03/01 00:00 [received]
PHST- 2012/08/21 00:00 [revised]
PHST- 2012/08/24 00:00 [accepted]
PHST- 2012/09/18 06:00 [entrez]
PHST- 2012/09/18 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - S0168-8510(12)00226-6 [pii]
AID - 10.1016/j.healthpol.2012.08.017 [doi]
PST - ppublish
SO  - Health Policy. 2013 Jan;109(1):97-103. doi: 10.1016/j.healthpol.2012.08.017. Epub
      2012 Sep 14.


PMID- 22981732
OWN - NLM
STAT- MEDLINE
DCOM- 20130423
LR  - 20211203
IS  - 1096-0260 (Electronic)
IS  - 0091-7435 (Linking)
VI  - 55
IP  - 5
DP  - 2012 Nov
TI  - Heterogeneity of risk within racial groups, a challenge for public health
      programs.
PG  - 405-8
LID - 10.1016/j.ypmed.2012.08.022 [doi]
LID - S0091-7435(12)00395-7 [pii]
AB  - Targeting high-risk populations for public health interventions is a classic tool
      of public health promotion programs. This practice becomes thornier when racial
      groups are identified as the at-risk populations. I present the particular
      ethical and epistemic challenges that arise when there are low-risk
      subpopulations within racial groups that have been identified as high-risk for a 
      particular health concern. I focus on two examples. The black immigrant
      population does not have the same hypertension risk as US-born African Americans.
      Similarly, Finnish descendants have a far lower rate of cystic fibrosis than
      other Caucasians. In both cases the exceptional nature of these subpopulations
      has been largely ignored by the designers of important public health efforts,
      including the recent US government dietary recommendations. I argue that amending
      the publicly-disseminated risk information to acknowledge these exceptions would 
      be desirable for several reasons. First, recognizing low-risk subpopulations
      would allow more efficient use of limited resources. Communicating this valuable 
      information to the subpopulations would also promote truth-telling. Finally,
      presenting a more nuanced empirically-supported representation of which groups
      are at known risk of diseases (not focusing on mere racial categories) would
      combat harmful biological race essentialist views held by the public.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Valles, Sean A
AU  - Valles SA
AD  - Lyman Briggs College and Department of Philosophy, Michigan State University,
      Holmes Hall, 919 E. Shaw Lane, East Lansing, MI 48825, USA. valles@msu.edu
LA  - eng
PT  - Journal Article
DEP - 20120908
PL  - United States
TA  - Prev Med
JT  - Preventive medicine
JID - 0322116
SB  - IM
MH  - African Americans
MH  - Blacks
MH  - *Cultural Diversity
MH  - Cystic Fibrosis/ethnology/genetics
MH  - Diet, Sodium-Restricted
MH  - Emigrants and Immigrants
MH  - Finland/ethnology
MH  - Genetic Testing
MH  - Health Promotion/ethics/*methods
MH  - *Health Status Disparities
MH  - Humans
MH  - Hypertension/diet therapy/ethnology
MH  - Risk Assessment
MH  - United States/epidemiology
MH  - Whites
EDAT- 2012/09/18 06:00
MHDA- 2013/04/24 06:00
CRDT- 2012/09/18 06:00
PHST- 2012/06/14 00:00 [received]
PHST- 2012/08/19 00:00 [revised]
PHST- 2012/08/29 00:00 [accepted]
PHST- 2012/09/18 06:00 [entrez]
PHST- 2012/09/18 06:00 [pubmed]
PHST- 2013/04/24 06:00 [medline]
AID - S0091-7435(12)00395-7 [pii]
AID - 10.1016/j.ypmed.2012.08.022 [doi]
PST - ppublish
SO  - Prev Med. 2012 Nov;55(5):405-8. doi: 10.1016/j.ypmed.2012.08.022. Epub 2012 Sep
      8.


PMID- 22981534
OWN - NLM
STAT- MEDLINE
DCOM- 20130521
LR  - 20121211
IS  - 1557-8615 (Electronic)
IS  - 0883-9441 (Linking)
VI  - 28
IP  - 1
DP  - 2013 Feb
TI  - Do-not-resuscitate order: a view throughout the world.
PG  - 14-21
LID - 10.1016/j.jcrc.2012.07.005 [doi]
LID - S0883-9441(12)00224-9 [pii]
AB  - Resuscitation has the ability to reverse premature death. It can also prolong
      terminal illness, increase discomfort, and consume resources. The
      do-not-resuscitate (DNR) order and advance directives are still a debated issue
      in critical care. This review will focus on several aspects, regarding
      withholding and/or withdrawing therapies and advance directives in different
      continents. It is widely known that there is a great diversity of cultural and
      religious beliefs in society, and therefore, some critical ethical and legal
      issues have still to be solved. To achieve a consensus, we believe in the
      priority of continuing education and training programs for health care
      professionals. It is our opinion that a serious reflection on ethical values and 
      principles would be useful to understand the definition of medical
      professionalism to make it possible to undertake the best way to avoid futile and
      aggressive care. There is evidence of the lack of DNR order policy worldwide.
      Therefore, it appears clear that there is a need for standardization. To improve 
      the attitude about the DNR order, it is necessary to achieve several goals such
      as: increased communication, consensus on law, increased trust among patients and
      health care systems, and improved standards and quality of care to respect the
      patient's will and the family's role.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Santonocito, Cristina
AU  - Santonocito C
AD  - Department of Anaesthesia and Intensive Care, Medical School of Catania,
      Policlinico-Vittorio Emanuele, Via S.Sofia, 78 95123 Catania, Italy.
      cristina.santonocito@gmail.com
FAU - Ristagno, Giuseppe
AU  - Ristagno G
FAU - Gullo, Antonino
AU  - Gullo A
FAU - Weil, Max Harry
AU  - Weil MH
LA  - eng
PT  - Journal Article
DEP - 20120913
PL  - United States
TA  - J Crit Care
JT  - Journal of critical care
JID - 8610642
SB  - IM
MH  - Advance Directives/ethics/ethnology/legislation & jurisprudence
MH  - *Attitude to Health
MH  - Cross-Cultural Comparison
MH  - *Cultural Diversity
MH  - Education, Continuing
MH  - Health Policy
MH  - *Healthcare Disparities
MH  - Humans
MH  - Quality of Health Care
MH  - Reference Standards
MH  - *Resuscitation Orders
EDAT- 2012/09/18 06:00
MHDA- 2013/05/23 06:00
CRDT- 2012/09/18 06:00
PHST- 2012/01/04 00:00 [received]
PHST- 2012/05/27 00:00 [revised]
PHST- 2012/07/04 00:00 [accepted]
PHST- 2012/09/18 06:00 [entrez]
PHST- 2012/09/18 06:00 [pubmed]
PHST- 2013/05/23 06:00 [medline]
AID - S0883-9441(12)00224-9 [pii]
AID - 10.1016/j.jcrc.2012.07.005 [doi]
PST - ppublish
SO  - J Crit Care. 2013 Feb;28(1):14-21. doi: 10.1016/j.jcrc.2012.07.005. Epub 2012 Sep
      13.


PMID- 22981247
OWN - NLM
STAT- MEDLINE
DCOM- 20130418
LR  - 20130304
IS  - 1878-5921 (Electronic)
IS  - 0895-4356 (Linking)
VI  - 66
IP  - 4
DP  - 2013 Apr
TI  - The withholding of test results as a means of assessing the effectiveness of
      treatment in test-positive persons.
PG  - 355-8
LID - 10.1016/j.jclinepi.2012.07.011 [doi]
LID - S0895-4356(12)00235-1 [pii]
AB  - In recent years, a number of studies have achieved randomization of patients to
      alternative management strategies by blinding some patients (and their providers 
      of medical care) to the results of tests that guide such strategies. Although
      this research approach has the potential to be a powerful means of measuring
      treatment effectiveness, the interpretation of the results may not be
      straightforward if the treatment received by test-positive persons is variable or
      not well documented, or if the analysis is not restricted to outcomes in
      test-positive persons. Studies in which the test results are withheld at random
      may face ethical issues that, to date, have received little discussion.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Weiss, Noel S
AU  - Weiss NS
AD  - University of Washington, Seattle, WA 98195, USA. nweiss@uw.edu
LA  - eng
PT  - Journal Article
DEP - 20120913
PL  - United States
TA  - J Clin Epidemiol
JT  - Journal of clinical epidemiology
JID - 8801383
SB  - IM
MH  - *Access to Information/ethics
MH  - Biomedical Research/ethics/*methods
MH  - Ethics, Research
MH  - Humans
MH  - Predictive Value of Tests
MH  - Randomized Controlled Trials as Topic/ethics/*methods
MH  - Treatment Outcome
MH  - Withholding Treatment/ethics
EDAT- 2012/09/18 06:00
MHDA- 2013/04/20 06:00
CRDT- 2012/09/18 06:00
PHST- 2012/03/05 00:00 [received]
PHST- 2012/07/09 00:00 [revised]
PHST- 2012/07/27 00:00 [accepted]
PHST- 2012/09/18 06:00 [entrez]
PHST- 2012/09/18 06:00 [pubmed]
PHST- 2013/04/20 06:00 [medline]
AID - S0895-4356(12)00235-1 [pii]
AID - 10.1016/j.jclinepi.2012.07.011 [doi]
PST - ppublish
SO  - J Clin Epidemiol. 2013 Apr;66(4):355-8. doi: 10.1016/j.jclinepi.2012.07.011. Epub
      2012 Sep 13.


PMID- 22980705
OWN - NLM
STAT- MEDLINE
DCOM- 20130208
LR  - 20151119
IS  - 1471-6348 (Electronic)
IS  - 0266-4623 (Linking)
VI  - 28
IP  - 3
DP  - 2012 Jul
TI  - Pre-market clinical evaluations of innovative high-risk medical devices in
      Europe.
PG  - 278-84
LID - 10.1017/S0266462312000335 [doi]
AB  - OBJECTIVES: High-quality clinical evidence is most often lacking when novel
      high-risk devices enter the European market. At the same time, a randomized
      controlled trial (RCT) is often initiated as a requirement for obtaining market
      access in the US. Should coverage in Europe be postponed until RCT data are
      available? We studied the premarket clinical evaluation of innovative high-risk
      medical devices in Europe compared with the US, and with medicines, where
      appropriate. METHODS: The literature and regulatory documents were checked.
      Representatives from industry, Competent Authorities, Notified Bodies, Ethics
      Committees, and HTA agencies were consulted. We also discuss patient safety and
      the transparency of information. RESULTS: In contrast to the US, there is no
      requirement in Europe to demonstrate the clinical efficacy of high-risk devices
      in the premarket phase. Patients in Europe can thus have earlier access to a
      potentially lifesaving device, but at the risk of insufficiently documented
      efficacy and safety. Variations in the stringency of clinical reviews, both at
      the level of Notified Bodies and Competent Authorities, do not guarantee patient 
      safety. We tried to document the design of premarket trials in Europe and number 
      of patients exposed, but failed as this information is not made public.
      Furthermore, the Helsinki Declaration is not followed with respect to the
      registration and publication of premarket trials. CONCLUSIONS: For innovative
      high-risk devices, new EU legislation should require the premarket demonstration 
      of clinical efficacy and safety, using an RCT if possible, and a transparent
      clinical review, preferably centralized.
FAU - Hulstaert, Frank
AU  - Hulstaert F
AD  - Belgian Health Care Knowledge Center (KCE), Brussels, Belgium.
      frank.hulstaert@kce.fgov.be
FAU - Neyt, Mattias
AU  - Neyt M
FAU - Vinck, Imgard
AU  - Vinck I
FAU - Stordeur, Sabine
AU  - Stordeur S
FAU - Huic, Mirjana
AU  - Huic M
FAU - Sauerland, Stefan
AU  - Sauerland S
FAU - Kuijpers, Marja R
AU  - Kuijpers MR
FAU - Abrishami, Payam
AU  - Abrishami P
FAU - Vondeling, Hindrik
AU  - Vondeling H
FAU - Flamion, Bruno
AU  - Flamion B
FAU - Garattini, Silvio
AU  - Garattini S
FAU - Pavlovic, Mira
AU  - Pavlovic M
FAU - van Brabandt, Hans
AU  - van Brabandt H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Technol Assess Health Care
JT  - International journal of technology assessment in health care
JID - 8508113
SB  - IM
MH  - *Equipment and Supplies
MH  - Europe
MH  - Risk Assessment
MH  - Surveys and Questionnaires
MH  - Technology Assessment, Biomedical/*methods/organization & administration
EDAT- 2012/09/18 06:00
MHDA- 2013/02/09 06:00
CRDT- 2012/09/18 06:00
PHST- 2012/09/18 06:00 [entrez]
PHST- 2012/09/18 06:00 [pubmed]
PHST- 2013/02/09 06:00 [medline]
AID - S0266462312000335 [pii]
AID - 10.1017/S0266462312000335 [doi]
PST - ppublish
SO  - Int J Technol Assess Health Care. 2012 Jul;28(3):278-84. doi:
      10.1017/S0266462312000335.


PMID- 22980703
OWN - NLM
STAT- MEDLINE
DCOM- 20130208
LR  - 20151119
IS  - 1471-6348 (Electronic)
IS  - 0266-4623 (Linking)
VI  - 28
IP  - 3
DP  - 2012 Jul
TI  - Deus ex machina or e-slave? Public perception of healthcare robotics in the
      German print media.
PG  - 265-70
LID - 10.1017/S0266462312000293 [doi]
AB  - OBJECTIVES: The news media plays a central role in providing information
      regarding new medical technologies and exerts an influence on their social
      perception, understanding, and assessments. This study, therefore, analyzes how
      healthcare robotics are portrayed in the German print news media. It examines
      whether the risks and opportunities of new medical technologies are presented in 
      a balanced manner and investigates whether or not print media coverage of these
      technologies is affected by science-fiction discourse, in which robots appear
      mostly as a threat to humans. METHODS: Ten years of German print media coverage
      (2000-2010) have been studied by means of systematic, standardized content
      analysis. RESULTS: Reporting focuses predominantly on beneficial advancements in 
      medical practice and the advantages of robotics for patients, medical staff, and 
      society. The results show that the dominant relationship between robots and
      humans that is transmitted in print media in medical contexts is positive, with
      robots mostly portrayed as assistants, colleagues, or even friends. Only a small 
      number of articles report ethical questions and risks. CONCLUSIONS: In contrast
      to science-fiction discourse, the German print media provides a positive picture 
      of robotics to the lay public.
FAU - Laryionava, Katsiaryna
AU  - Laryionava K
AD  - RWTH Aachen University, Aachen, Germany. katsiaryna.laryionava@rwth-aachen.de
FAU - Gross, Dominik
AU  - Gross D
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Technol Assess Health Care
JT  - International journal of technology assessment in health care
JID - 8508113
SB  - IM
MH  - Bibliometrics
MH  - Germany
MH  - Humans
MH  - *Mass Media
MH  - *Public Opinion
MH  - *Robotics
MH  - Surveys and Questionnaires
EDAT- 2012/09/18 06:00
MHDA- 2013/02/09 06:00
CRDT- 2012/09/18 06:00
PHST- 2012/09/18 06:00 [entrez]
PHST- 2012/09/18 06:00 [pubmed]
PHST- 2013/02/09 06:00 [medline]
AID - S0266462312000293 [pii]
AID - 10.1017/S0266462312000293 [doi]
PST - ppublish
SO  - Int J Technol Assess Health Care. 2012 Jul;28(3):265-70. doi:
      10.1017/S0266462312000293.


PMID- 22980697
OWN - NLM
STAT- MEDLINE
DCOM- 20130208
LR  - 20220330
IS  - 1471-6348 (Electronic)
IS  - 0266-4623 (Linking)
VI  - 28
IP  - 3
DP  - 2012 Jul
TI  - Health technology reassessment of non-drug technologies: current practices.
PG  - 220-7
LID - 10.1017/S0266462312000438 [doi]
AB  - OBJECTIVES: Obsolescence is a natural phase of the lifecycle of health
      technologies. Given increasing cost of health expenditures worldwide, health
      organizations have little choice but to engage in health technology reassessment 
      (HTR); a structured, evidence-based assessment of the medical, social, ethical,
      and economic effects of a technology, currently used within the healthcare
      system, to inform optimal use of that technology in comparison to its
      alternatives. This research was completed to identify and summarize international
      HTR initiatives for non-drug technologies. METHODS: A systematic review was
      performed using the terms disinvestment, obsolescence, obsolete technology,
      ineffective, reassessment, reinvestment, reallocation, program budgeting, and
      marginal analysis to search PubMED, MEDLINE, EMBASE, and CINAHL until November
      2011. Websites of organizations listed as members of INAHTA and HTAi were
      hand-searched for gray literature. Documents were excluded if they were
      unavailable in English, if the title/abstract was irrelevant to HTR, and/or if
      the document made no mention of current practices. All citations were screened in
      duplicate with disagreements resolved by consensus. RESULTS: Sixty full-text
      documents were reviewed and forty were included. One model for reassessment was
      identified; however, it has never been put into practice. Eight countries have
      some evidence of past or current work related to reassessment; seven have shown
      evidence of continued work in HTR. There is negligible focus on monitoring and
      implementation. CONCLUSIONS: HTR is in its infancy. Although health technology
      reassessments are being conducted, there is no standardized approach. Future work
      should focus on developing and piloting a comprehensive methodology for
      completing HTR.
FAU - Leggett, Laura
AU  - Leggett L
AD  - University of Calgary; Institute of Public Health, Calgary, Alberta, Canada.
      lelegget@ucalgary.ca
FAU - Noseworthy, Tom W
AU  - Noseworthy TW
FAU - Zarrabi, Mahmood
AU  - Zarrabi M
FAU - Lorenzetti, Diane
AU  - Lorenzetti D
FAU - Sutherland, Lloyd R
AU  - Sutherland LR
FAU - Clement, Fiona M
AU  - Clement FM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
PL  - England
TA  - Int J Technol Assess Health Care
JT  - International journal of technology assessment in health care
JID - 8508113
SB  - IM
MH  - Biomedical Technology/*standards
MH  - Internationality
MH  - *Technology Assessment, Biomedical
EDAT- 2012/09/18 06:00
MHDA- 2013/02/09 06:00
CRDT- 2012/09/18 06:00
PHST- 2012/09/18 06:00 [entrez]
PHST- 2012/09/18 06:00 [pubmed]
PHST- 2013/02/09 06:00 [medline]
AID - S0266462312000438 [pii]
AID - 10.1017/S0266462312000438 [doi]
PST - ppublish
SO  - Int J Technol Assess Health Care. 2012 Jul;28(3):220-7. doi:
      10.1017/S0266462312000438.


PMID- 22980295
OWN - NLM
STAT- MEDLINE
DCOM- 20121207
LR  - 20130507
IS  - 1097-6744 (Electronic)
IS  - 0002-8703 (Linking)
VI  - 164
IP  - 3
DP  - 2012 Sep
TI  - Implications of geographical variation on clinical outcomes of cardiovascular
      trials.
PG  - 303-12
LID - 10.1016/j.ahj.2012.06.006 [doi]
LID - S0002-8703(12)00386-9 [pii]
AB  - Cardiovascular clinical trials are increasingly conducted globally as a means to 
      reduce costs, expedite timelines, provide broad applicability, and satisfy
      regulatory authorities. Potential problems with trial globalization include
      regional differences in patient characteristics, medical practice patterns, and
      health policies which may influence outcomes and limit generalizability.
      Moreover, concerns have been raised about ethical misconduct and unsatisfactory
      quality oversight in regions with less trial experience and infrastructure. This 
      article reviews geographical differences in cardiovascular trials in heart
      failure, acute coronary syndromes, hypertension and atrial fibrillation. It also 
      explores potential explanations for these differences and methods to standardize 
      the presentation of trial results. This review is based on discussions between
      basic scientists and clinical trialists at the 8th Global Cardio Vascular
      Clinical Trialists Forum 2011 in Paris, France, from December 2 to 3.
CI  - Copyright (c) 2012 Mosby, Inc. All rights reserved.
FAU - Mentz, Robert J
AU  - Mentz RJ
AD  - Duke University Medical Center, Durham, NC, USA. robert.mentz@duke.edu
FAU - Kaski, Juan-Carlos
AU  - Kaski JC
FAU - Dan, Gheorghe-Andrei
AU  - Dan GA
FAU - Goldstein, Sidney
AU  - Goldstein S
FAU - Stockbridge, Norman
AU  - Stockbridge N
FAU - Alonso-Garcia, Angeles
AU  - Alonso-Garcia A
FAU - Ruilope, Luis M
AU  - Ruilope LM
FAU - Martinez, Felipe A
AU  - Martinez FA
FAU - Zannad, Faiez
AU  - Zannad F
FAU - Pitt, Bertram
AU  - Pitt B
FAU - Fiuzat, Mona
AU  - Fiuzat M
FAU - O'Connor, Christopher M
AU  - O'Connor CM
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120803
PL  - United States
TA  - Am Heart J
JT  - American heart journal
JID - 0370465
SB  - IM
CIN - Am Heart J. 2013 Apr;165(4):e13. PMID: 23537983
CIN - Am Heart J. 2013 Apr;165(4):e15. PMID: 23537984
MH  - Cardiovascular Diseases/*therapy
MH  - Clinical Trials as Topic/ethics/*standards
MH  - Geography
MH  - Humans
MH  - Internationality
MH  - Treatment Outcome
EDAT- 2012/09/18 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/09/18 06:00
PHST- 2012/04/30 00:00 [received]
PHST- 2012/06/07 00:00 [accepted]
PHST- 2012/09/18 06:00 [entrez]
PHST- 2012/09/18 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - S0002-8703(12)00386-9 [pii]
AID - 10.1016/j.ahj.2012.06.006 [doi]
PST - ppublish
SO  - Am Heart J. 2012 Sep;164(3):303-12. doi: 10.1016/j.ahj.2012.06.006. Epub 2012 Aug
      3.


PMID- 22978774
OWN - NLM
STAT- MEDLINE
DCOM- 20130403
LR  - 20121026
IS  - 1473-4877 (Electronic)
IS  - 0300-7995 (Linking)
VI  - 28
IP  - 10
DP  - 2012 Oct
TI  - Publication misconduct and plagiarism retractions: a systematic, retrospective
      study.
PG  - 1575-83
LID - 10.1185/03007995.2012.728131 [doi]
AB  - OBJECTIVES: To investigate whether plagiarism is more prevalent in publications
      retracted from the medical literature when first authors are affiliated with
      lower-income countries versus higher-income countries. Secondary objectives
      included investigating other factors associated with plagiarism (e.g., national
      language of the first author's country affiliation, publication type, journal
      ranking). DESIGN: Systematic, controlled, retrospective, bibliometric study. DATA
      SOURCE: Retracted publications dataset in MEDLINE (search filters: English,
      human, January 1966-February 2008). DATA SELECTION: Retracted misconduct
      publications were classified according to the first author's country affiliation,
      country income level, and country national language, publication type, and
      ranking of the publishing journal. Standardised definitions and data collection
      tools were used; data were analysed (odds ratio [OR], 95% confidence limits [CL],
      chi-squared tests) by an independent academic statistician. RESULTS: Of the 213
      retracted misconduct publications, 41.8% (89/213) were retracted for plagiarism, 
      52.1% (111/213) for falsification/fabrication, 2.3% (5/213) for author disputes, 
      2.3% (5/213) for ethical issues, and 1.4% (3/213) for unknown reasons. The OR
      (95% CL) of plagiarism retractions (other misconduct retractions as reference)
      were higher (P < 0.001) for first authors affiliated with lower-income versus
      higher-income countries (15.4 [4.5, 52.9]) and with non-English versus English
      national language countries (3.2 [1.8, 5.7]), for non-original research versus
      original research publications (8.4 [3.3, 21.3]), for case reports and series
      versus other original research types (4.2 [1.4, 13.0]), and for publications in
      low-ranked versus high-ranked journals (4.9 [2.4, 9.9]). Up until 2012, there
      were significantly (P < 0.007) fewer 'serial offenders' (first authors with >1
      retraction) with publications retracted for plagiarism (11.5%, 9/78) than other
      types of misconduct (28.9%, 24/83). CONCLUSIONS: This is the first study to
      demonstrate that publications retracted for plagiarism are significantly
      associated with first authors affiliated with lower-income countries. These
      findings have implications for developing appropriate evidence-based strategies
      and allocation of resources to help mitigate plagiarism misconduct.
FAU - Stretton, Serina
AU  - Stretton S
AD  - ProScribe Medical Communications, Noosaville, Queensland, Australia.
      ss@proscribe.com.au
FAU - Bramich, Narelle J
AU  - Bramich NJ
FAU - Keys, Janelle R
AU  - Keys JR
FAU - Monk, Julie A
AU  - Monk JA
FAU - Ely, Julie A
AU  - Ely JA
FAU - Haley, Cassandra
AU  - Haley C
FAU - Woolley, Mark J
AU  - Woolley MJ
FAU - Woolley, Karen L
AU  - Woolley KL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121009
PL  - England
TA  - Curr Med Res Opin
JT  - Current medical research and opinion
JID - 0351014
SB  - IM
CIN - Curr Med Res Opin. 2013 Feb;29(2):99-100. PMID: 23210610
MH  - Biomedical Research/*ethics
MH  - Humans
MH  - MEDLINE
MH  - *Periodicals as Topic
MH  - *Plagiarism
MH  - *Retraction of Publication as Topic
MH  - Scientific Misconduct/*ethics
EDAT- 2012/09/18 06:00
MHDA- 2013/04/04 06:00
CRDT- 2012/09/18 06:00
PHST- 2012/09/18 06:00 [entrez]
PHST- 2012/09/18 06:00 [pubmed]
PHST- 2013/04/04 06:00 [medline]
AID - 10.1185/03007995.2012.728131 [doi]
PST - ppublish
SO  - Curr Med Res Opin. 2012 Oct;28(10):1575-83. doi: 10.1185/03007995.2012.728131.
      Epub 2012 Oct 9.


PMID- 22978443
OWN - NLM
STAT- MEDLINE
DCOM- 20130304
LR  - 20211021
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 13
DP  - 2012 Sep 15
TI  - Flexible trial design in practice - stopping arms for lack-of-benefit and adding 
      research arms mid-trial in STAMPEDE: a multi-arm multi-stage randomized
      controlled trial.
PG  - 168
LID - 10.1186/1745-6215-13-168 [doi]
AB  - BACKGROUND: Systemic Therapy for Advanced or Metastatic Prostate cancer:
      Evaluation of Drug Efficacy (STAMPEDE) is a randomized controlled trial that
      follows a novel multi-arm, multi-stage (MAMS) design. We describe methodological 
      and practical issues arising with (1) stopping recruitment to research arms
      following a pre-planned intermediate analysis and (2) adding a new research arm
      during the trial. METHODS: STAMPEDE recruits men who have locally advanced or
      metastatic prostate cancer who are starting standard long-term hormone therapy.
      Originally there were five research and one control arms, each undergoing a pilot
      stage (focus: safety, feasibility), three intermediate 'activity' stages (focus: 
      failure-free survival), and a final 'efficacy' stage (focus: overall survival).
      Lack-of-sufficient-activity guidelines support the pairwise interim comparisons
      of each research arm against the control arm; these pre-defined activity cut-off 
      becomes increasingly stringent over the stages. Accrual of further patients
      continues to the control arm and to those research arms showing activity and an
      acceptable safety profile. The design facilitates adding new research arms should
      sufficiently interesting agents emerge. These new arms are compared only to
      contemporaneously recruited control arm patients using the same intermediate
      guidelines in a time-delayed manner. The addition of new research arms is subject
      to adequate recruitment rates to support the overall trial aims. RESULTS: (1)
      Stopping Existing Therapy: After the second intermediate activity analysis,
      recruitment was discontinued to two research arms for lack-of-sufficient
      activity. Detailed preparations meant that changes were implemented swiftly at
      100 international centers and recruitment continued seamlessly into Activity
      Stage III with 3 remaining research arms and the control arm. Further regulatory 
      and ethical approvals were not required because this was already included in the 
      initial trial design.(2) Adding New Therapy: An application to add a new research
      arm was approved by the funder, (who also organized peer review), industrial
      partner and regulatory and ethical bodies. This was all done in advance of any
      decision to stop current therapies. CONCLUSIONS: The STAMPEDE experience shows
      that recruitment to a MAMS trial and mid-flow changes its design are achievable
      with good planning. This benefits patients and the scientific community as
      research treatments are evaluated in a more efficient and cost-effective manner. 
      TRIAL REGISTRATION: ISRCTN78818544, NCT00268476. First patient into trial: 17
      October 2005. First patient into abiraterone comparison: 15 November 2011.
FAU - Sydes, Matthew R
AU  - Sydes MR
AD  - MRC Clinical Trials Unit, London, UK. matthew.sydes@ctu.mrc.ac.uk
FAU - Parmar, Mahesh K B
AU  - Parmar MK
FAU - Mason, Malcolm D
AU  - Mason MD
FAU - Clarke, Noel W
AU  - Clarke NW
FAU - Amos, Claire
AU  - Amos C
FAU - Anderson, John
AU  - Anderson J
FAU - de Bono, Johann
AU  - de Bono J
FAU - Dearnaley, David P
AU  - Dearnaley DP
FAU - Dwyer, John
AU  - Dwyer J
FAU - Green, Charlene
AU  - Green C
FAU - Jovic, Gordana
AU  - Jovic G
FAU - Ritchie, Alastair W S
AU  - Ritchie AW
FAU - Russell, J Martin
AU  - Russell JM
FAU - Sanders, Karen
AU  - Sanders K
FAU - Thalmann, George
AU  - Thalmann G
FAU - James, Nicholas D
AU  - James ND
LA  - eng
SI  - ISRCTN/ISRCTN78818544
SI  - ClinicalTrials.gov/NCT00268476
GR  - 3804/CRUK_/Cancer Research UK/United Kingdom
GR  - MC_U122861330/MRC_/Medical Research Council/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
DEP - 20120915
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
RN  - 0 (Antineoplastic Agents, Hormonal)
SB  - IM
MH  - Antineoplastic Agents, Hormonal/adverse effects/*therapeutic use
MH  - Disease-Free Survival
MH  - Humans
MH  - Male
MH  - Patient Selection
MH  - Prostatic Neoplasms/*drug therapy/mortality/pathology
MH  - *Research Design
MH  - Survival Analysis
MH  - Switzerland
MH  - Time Factors
MH  - Treatment Outcome
MH  - United Kingdom
PMC - PMC3466132
EDAT- 2012/09/18 06:00
MHDA- 2013/03/05 06:00
CRDT- 2012/09/18 06:00
PHST- 2012/03/09 00:00 [received]
PHST- 2012/08/16 00:00 [accepted]
PHST- 2012/09/18 06:00 [entrez]
PHST- 2012/09/18 06:00 [pubmed]
PHST- 2013/03/05 06:00 [medline]
AID - 1745-6215-13-168 [pii]
AID - 10.1186/1745-6215-13-168 [doi]
PST - epublish
SO  - Trials. 2012 Sep 15;13:168. doi: 10.1186/1745-6215-13-168.


PMID- 22977970
OWN - NLM
STAT- MEDLINE
DCOM- 20121002
LR  - 20120917
IS  - 1565-1088 (Print)
VI  - 14
IP  - 8
DP  - 2012 Aug
TI  - Ethical challenges posed by trisomy 18 infants.
PG  - 498-500
FAU - Prager, Kenneth
AU  - Prager K
FAU - Hardart, George
AU  - Hardart G
LA  - eng
PT  - Editorial
PL  - Israel
TA  - Isr Med Assoc J
JT  - The Israel Medical Association journal : IMAJ
JID - 100930740
RN  - Chromosome 18, trisomy 18p
SB  - IM
MH  - Amniocentesis
MH  - Chromosomes, Human, Pair 18
MH  - *Ethics, Medical
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Pregnancy
MH  - *Trisomy
EDAT- 2012/09/18 06:00
MHDA- 2012/10/04 06:00
CRDT- 2012/09/18 06:00
PHST- 2012/09/18 06:00 [entrez]
PHST- 2012/09/18 06:00 [pubmed]
PHST- 2012/10/04 06:00 [medline]
PST - ppublish
SO  - Isr Med Assoc J. 2012 Aug;14(8):498-500.


PMID- 22977898
OWN - NLM
STAT- MEDLINE
DCOM- 20121010
LR  - 20191027
IS  - 1294-9361 (Print)
IS  - 1294-9361 (Linking)
VI  - 14
IP  - 2
DP  - 2012 Jun
TI  - What clinical trial designs have been used to test antiepileptic drugs and do we 
      need to change them?
PG  - 124-31
AB  - Designs used to evaluate the efficacy and safety of antiepileptic drugs (AEDs)
      have evolved considerably over the years. A major impulse to develop
      methodologically sound randomised controlled trials dates back to the
      Kefauver-Harris Drug Amendment of 1962, through which the US congress introduced 
      the requirement of substantial evidence for proof of efficacy in a new drug
      application. The mainstay for the initial approval of most new AEDs has been, and
      still is, the placebo-controlled adjunctive therapy trial, which evolved over the
      years from the cross-over to the parallel-group design. In the early days, when
      few AEDs were available, enrolment of patients into these trials was relatively
      easy and prolonged placebo exposure could be justified by lack of alternative
      treatment options. With more than 20 drugs now available to treat epilepsy,
      however, exposing patients to placebo or to a potentially ineffective
      investigational agent faces practical and ethical concerns. Recruitment
      difficulties have led sponsors to markedly increase the number of trial sites,
      but there is evidence that this may adversely affect the ability to differentiate
      between effective and ineffective treatments. Methodological and practical
      difficulties are also encountered with monotherapy trials. Because regulatory
      guidelines for monotherapy approval differ between Europe and the US, sponsors
      need to pursue separate and costly development programs on the two sides of the
      Atlantic. Moreover, the scientific validity of the monotherapy trial paradigms
      currently used in Europe (the non-inferiority design) and in the US (the
      conversion to monotherapy design with historical controls) has been questioned.
      This article will review these issues in some detail and discuss how trial
      designs and regulatory approval processes may evolve in the future to address
      these concerns.
FAU - Perucca, Emilio
AU  - Perucca E
AD  - Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics,
      University of Pavia, Pavia, Italy. perucca@unipv.it
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Review
PL  - France
TA  - Epileptic Disord
JT  - Epileptic disorders : international epilepsy journal with videotape
JID - 100891853
RN  - 0 (Anticonvulsants)
SB  - IM
MH  - Anticonvulsants/history/*therapeutic use
MH  - Clinical Trials as Topic/history/trends
MH  - Epilepsy/*drug therapy/history
MH  - History, 20th Century
MH  - Humans
MH  - Reproducibility of Results
MH  - *Research Design
EDAT- 2012/09/15 06:00
MHDA- 2012/10/12 06:00
CRDT- 2012/09/15 06:00
PHST- 2012/09/15 06:00 [entrez]
PHST- 2012/09/15 06:00 [pubmed]
PHST- 2012/10/12 06:00 [medline]
AID - 10.1684/epd.2012.0511 [doi]
PST - ppublish
SO  - Epileptic Disord. 2012 Jun;14(2):124-31. doi: 10.1684/epd.2012.0511.


PMID- 22977316
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120917
LR  - 20211021
IS  - 1179-2736 (Electronic)
IS  - 1179-2736 (Linking)
VI  - 3
DP  - 2012
TI  - Ethical and legal considerations regarding the ownership and commercial use of
      human biological materials and their derivatives.
PG  - 87-96
LID - 10.2147/JBM.S36134 [doi]
AB  - This article considers some of the ethical and legal issues relating to the
      ownership and use - including for commercial purposes - of biological material
      and products derived from humans. The discussion is divided into three parts:
      after first examining the general notion of ownership, it moves to the particular
      case of possible commercial use, and finally reflects on the case in point in the
      light of the preceding considerations. Units of cord blood donated altruistically
      for transplantation and which are found unsuitable for storage and
      transplantation, or which become unsuitable while stored in biobanks, are taken
      as an example. These cord-blood units can be discarded together with other
      biological waste, or they can be used for research or the development of
      blood-derived products such as platelet gel. Several ethical questions (eg,
      informed consent, property, distribution of profits, and others) arise from these
      circumstances. In this regard, some criteria and limits to use are proposed.
FAU - Petrini, Carlo
AU  - Petrini C
AD  - Italian National Institute of Health, Rome, Italy.
LA  - eng
PT  - Journal Article
DEP - 20120807
PL  - New Zealand
TA  - J Blood Med
JT  - Journal of blood medicine
JID - 101550884
EIN - J Blood Med. 2018 Oct 25;9:193. PMID: 30464669
PMC - PMC3440234
OTO - NOTNLM
OT  - bioethics
OT  - biological specimen banks
OT  - cord-blood stem cell transplantation
OT  - ethics
OT  - informed consent
OT  - legislation
EDAT- 2012/09/15 06:00
MHDA- 2012/09/15 06:01
CRDT- 2012/09/15 06:00
PHST- 2012/09/15 06:00 [entrez]
PHST- 2012/09/15 06:00 [pubmed]
PHST- 2012/09/15 06:01 [medline]
AID - 10.2147/JBM.S36134 [doi]
AID - jbm-3-087 [pii]
PST - ppublish
SO  - J Blood Med. 2012;3:87-96. doi: 10.2147/JBM.S36134. Epub 2012 Aug 7.


PMID- 22977064
OWN - NLM
STAT- MEDLINE
DCOM- 20130510
LR  - 20121130
IS  - 1473-4265 (Electronic)
IS  - 1468-215X (Linking)
VI  - 38
IP  - 2
DP  - 2012 Dec
TI  - Performance and palliative care: a drama module for medical students.
PG  - 110-4
LID - 10.1136/medhum-2012-010203 [doi]
AB  - This paper describes an innovative 2 weeks module for medical students
      facilitated by drama educators and a palliative medicine doctor. The module
      incorporates drama, end-of-life care, teamwork and reflective practice. The
      module contents, practical aspects of drama teaching and learning outcomes are
      discussed. Various themes emerged from a study of Harold Pinter's play, The
      Caretaker, which were relevant to clinical practice: silence, power,
      communication, uncertainty and unanswered questions. Drama teaching may be one
      way of enhancing students' confidence, increasing self- awareness, developing
      ethical thinking and fostering teamworking.
FAU - Jeffrey, Ewan James
AU  - Jeffrey EJ
AD  - Department of Languages, Literatures, Performing Arts, Queen's University
      Belfast, Belfast, Northern Ireland, UK.
FAU - Goddard, Jen
AU  - Goddard J
FAU - Jeffrey, David
AU  - Jeffrey D
LA  - eng
PT  - Journal Article
DEP - 20120912
PL  - United States
TA  - Med Humanit
JT  - Medical humanities
JID - 100959585
SB  - IM
MH  - Awareness
MH  - Cooperative Behavior
MH  - Curriculum
MH  - *Drama
MH  - Education, Medical, Undergraduate/*methods
MH  - Humans
MH  - *Learning
MH  - *Palliative Care
MH  - *Physician-Patient Relations/ethics
MH  - Self Efficacy
MH  - Students, Medical
MH  - Teaching/*methods
MH  - *Terminal Care
MH  - Thinking
EDAT- 2012/09/15 06:00
MHDA- 2013/05/11 06:00
CRDT- 2012/09/15 06:00
PHST- 2012/09/15 06:00 [entrez]
PHST- 2012/09/15 06:00 [pubmed]
PHST- 2013/05/11 06:00 [medline]
AID - medhum-2012-010203 [pii]
AID - 10.1136/medhum-2012-010203 [doi]
PST - ppublish
SO  - Med Humanit. 2012 Dec;38(2):110-4. doi: 10.1136/medhum-2012-010203. Epub 2012 Sep
      12.


PMID- 22977062
OWN - NLM
STAT- MEDLINE
DCOM- 20130227
LR  - 20121126
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 12
DP  - 2012 Dec
TI  - Bioethical dilemmas of assisted reproduction in the opinions of Polish women in
      infertility treatment: a research report.
PG  - 731-4
LID - 10.1136/medethics-2011-100421 [doi]
AB  - Infertility Accepted treatment is replete with bioethical dilemmas regarding the 
      limits of available medical therapies. Poland has no legal acts regulating the
      ethical problems associated with infertility treatment and work on such
      legislation has been in progress for a long time, arousing very intense emotions 
      in Polish society. The purpose of the present study was to find out what Polish
      women undergoing infertility treatment think about the most disputable and
      controversial bioethical problems of assisted reproduction. An Attitudes towards 
      Bioethical Problems of Infertility Scale was constructed specifically for this
      study. Items were taken from the Bioethics Bills currently under discussion in
      Polish Parliament (Seym). 312 women were enrolled in the study. Women
      experiencing infertility favoured more liberal legislation. Participants
      disagreed, for example, with the following regulations: prohibition of embryo
      freezing, prohibition of preimplantation genetic diagnosis of embryos, age limits
      for women using in vitro fertilisation and prohibition of in vitro fertilisation 
      for single women. The opinions of patients undergoing infertility treatment are
      an important voice in the Polish debate on the Bioethics Bills.
FAU - Dembinska, Aleksandra
AU  - Dembinska A
AD  - Social Sciences Institute, Katowice School of Economics, Harcerzy Wrzesnia 3,
      Katowice 40-659, Poland. a.dembinska@interia.pl
LA  - eng
PT  - Journal Article
DEP - 20120912
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Cryopreservation/ethics
MH  - Female
MH  - Fertilization in Vitro/ethics/legislation & jurisprudence
MH  - Health Policy/*legislation & jurisprudence/trends
MH  - Homosexuality, Female
MH  - Humans
MH  - Infertility/therapy
MH  - Marital Status
MH  - Poland
MH  - Preimplantation Diagnosis/ethics
MH  - *Public Opinion
MH  - Reproductive Techniques, Assisted/*ethics/*legislation & jurisprudence
EDAT- 2012/09/15 06:00
MHDA- 2013/02/28 06:00
CRDT- 2012/09/15 06:00
PHST- 2012/09/15 06:00 [entrez]
PHST- 2012/09/15 06:00 [pubmed]
PHST- 2013/02/28 06:00 [medline]
AID - medethics-2011-100421 [pii]
AID - 10.1136/medethics-2011-100421 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Dec;38(12):731-4. doi: 10.1136/medethics-2011-100421. Epub
      2012 Sep 12.


PMID- 22976757
OWN - NLM
STAT- MEDLINE
DCOM- 20130122
LR  - 20181201
IS  - 0016-3813 (Print)
IS  - 0016-3813 (Linking)
VI  - 148
IP  - 4
DP  - 2012 Jul-Aug
TI  - [Health in Mexico: old and rising challenges. An updated assessment].
PG  - 390-9
AB  - In recent decades, Mexico has come a long way in health care matters, which has
      influenced the standard of living of the population and the development of the
      country. However, much remains to be done and changes should happen faster. Some 
      of the main challenges Mexico faces currently are presented in this document and 
      include: the challenge of reducing poverty in order to improve the health status 
      of society; the development of health services that affect the slowdown in the
      pace of evolution of demographic indicators, life expectancy at birth and infant 
      mortality; the challenge of reducing inequality; the challenge of great
      infrastructure available in the country for health care and the limited
      performance obtained in terms of organization, management and financing; the
      challenge resulting from human resources training systems, both undergraduate and
      postgraduate; the challenge that relates to academic and scientific productivity;
      the challenge of diabetes as an example of a serious public health problem; and
      the challenge of ethical implications in the organization and administration of
      health services, specifically, the allocation of public resources to them.
FAU - Narro Robles, Jose
AU  - Narro Robles J
AD  - Rectoria, Universidad Nacional Autonoma de Mexico, Mexico.
FAU - Zepeda Tena, Carolina
AU  - Zepeda Tena C
LA  - spa
PT  - Journal Article
TT  - La salud en Mexico: antiguos y nacientes desafios. Un examen actualizado.
PL  - Mexico
TA  - Gac Med Mex
JT  - Gaceta medica de Mexico
JID - 0010333
SB  - IM
MH  - Delivery of Health Care/*standards
MH  - Healthcare Disparities
MH  - Humans
MH  - Mexico
MH  - Workforce
EDAT- 2012/09/15 06:00
MHDA- 2013/01/23 06:00
CRDT- 2012/09/15 06:00
PHST- 2012/09/15 06:00 [entrez]
PHST- 2012/09/15 06:00 [pubmed]
PHST- 2013/01/23 06:00 [medline]
PST - ppublish
SO  - Gac Med Mex. 2012 Jul-Aug;148(4):390-9.


PMID- 22976285
OWN - NLM
STAT- MEDLINE
DCOM- 20131119
LR  - 20211021
IS  - 1573-3394 (Electronic)
IS  - 1065-3058 (Linking)
VI  - 20
IP  - 4
DP  - 2012 Dec
TI  - Enhancement technology and outcomes: what professionals and researchers can learn
      from those skeptical about cochlear implants.
PG  - 367-84
LID - 10.1007/s10728-012-0225-0 [doi]
AB  - This text presents an overview of the bioethical debate on pediatric cochlear
      implants and pays particular attention to the analysis of the Deaf critique of
      implantation. It dismisses the idea that Deaf concerns are primarily about the
      upholding of Deaf culture and sign language. Instead it is argued that Deaf
      skepticism about child rehabilitation after cochlear surgery is well founded.
      Many Deaf people have lived experiences as subjects undergoing rehabilitation. It
      is not the cochlear technology in itself they view as problematic, but rather the
      subsequent rehabilitation process. Because they themselves have experienced what 
      they describe as harmful effects which relate above all to the idea of
      normalization, they have articulated worries for the new generations of deaf
      children in need of rehabilitation following cochlear implant surgery. These
      insights have attracted little attention, but could represent relevant ethical
      questions of which both practitioners and researchers in the field of
      implantation might be aware.
FAU - Kermit, Patrick
AU  - Kermit P
AD  - NTNU Social Research, Dragvoll Alle 38B, 7491, Trondheim, Norway.
      patrick.kermit@samfunn.ntnu.no
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Health Care Anal
JT  - Health care analysis : HCA : journal of health philosophy and policy
JID - 9432537
MH  - *Biomedical Enhancement
MH  - Child
MH  - Cochlear Implantation/*ethics/*rehabilitation
MH  - *Cochlear Implants
MH  - Deafness/surgery
MH  - Female
MH  - Humans
MH  - Male
MH  - Outcome Assessment, Health Care
EDAT- 2012/09/15 06:00
MHDA- 2013/11/20 06:00
CRDT- 2012/09/15 06:00
PHST- 2012/09/15 06:00 [entrez]
PHST- 2012/09/15 06:00 [pubmed]
PHST- 2013/11/20 06:00 [medline]
AID - 10.1007/s10728-012-0225-0 [doi]
PST - ppublish
SO  - Health Care Anal. 2012 Dec;20(4):367-84. doi: 10.1007/s10728-012-0225-0.


PMID- 22975759
OWN - NLM
STAT- MEDLINE
DCOM- 20130816
LR  - 20220317
IS  - 1530-0366 (Electronic)
IS  - 1098-3600 (Linking)
VI  - 15
IP  - 3
DP  - 2013 Mar
TI  - Informatics and clinical genome sequencing: opening the black box.
PG  - 165-71
LID - 10.1038/gim.2012.116 [doi]
AB  - Adoption of whole-genome sequencing as a routine biomedical tool is dependent not
      only on the availability of new high-throughput sequencing technologies, but also
      on the concomitant development of methods and tools for data collection,
      analysis, and interpretation. It would also be enormously facilitated by the
      development of decision support systems for clinicians and consideration of how
      such information can best be incorporated into care pathways. Here we present an 
      overview of the data analysis and interpretation pipeline, the wider informatics 
      needs, and some of the relevant ethical and legal issues.
FAU - Moorthie, Sowmiya
AU  - Moorthie S
AD  - PHG Foundation, Cambridge, UK.
FAU - Hall, Alison
AU  - Hall A
FAU - Wright, Caroline F
AU  - Wright CF
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120913
PL  - United States
TA  - Genet Med
JT  - Genetics in medicine : official journal of the American College of Medical
      Genetics
JID - 9815831
SB  - IM
MH  - Computational Biology/methods
MH  - Confidentiality
MH  - Decision Support Techniques
MH  - *Genome, Human
MH  - Humans
MH  - Information Dissemination
MH  - *Medical Informatics
MH  - Molecular Sequence Annotation
MH  - Physicians
MH  - Software
EDAT- 2012/09/15 06:00
MHDA- 2013/08/21 06:00
CRDT- 2012/09/15 06:00
PHST- 2012/09/15 06:00 [entrez]
PHST- 2012/09/15 06:00 [pubmed]
PHST- 2013/08/21 06:00 [medline]
AID - S1098-3600(21)04238-6 [pii]
AID - 10.1038/gim.2012.116 [doi]
PST - ppublish
SO  - Genet Med. 2013 Mar;15(3):165-71. doi: 10.1038/gim.2012.116. Epub 2012 Sep 13.


PMID- 22975613
OWN - NLM
STAT- MEDLINE
DCOM- 20130114
LR  - 20211021
IS  - 1879-355X (Electronic)
IS  - 0360-3016 (Linking)
VI  - 84
IP  - 5
DP  - 2012 Dec 1
TI  - Kilovoltage intrafraction monitoring for prostate intensity modulated arc
      therapy: first clinical results.
PG  - e655-61
LID - 10.1016/j.ijrobp.2012.07.2367 [doi]
LID - S0360-3016(12)03312-3 [pii]
AB  - PURPOSE: Most linear accelerators purchased today are equipped with a
      gantry-mounted kilovoltage X-ray imager which is typically used for patient
      imaging prior to therapy. A novel application of the X-ray system is kilovoltage 
      intrafraction monitoring (KIM), in which the 3-dimensional (3D) tumor position is
      determined during treatment. In this paper, we report on the first use of KIM in 
      a prospective clinical study of prostate cancer patients undergoing intensity
      modulated arc therapy (IMAT). METHODS AND MATERIALS: Ten prostate cancer patients
      with implanted fiducial markers undergoing conventionally fractionated IMAT
      (RapidArc) were enrolled in an ethics-approved study of KIM. KIM involves
      acquiring kV images as the gantry rotates around the patient during treatment.
      Post-treatment, markers in these images were segmented to obtain 2D positions.
      From the 2D positions, a maximum likelihood estimation of a probability density
      function was used to obtain 3D prostate trajectories. The trajectories were
      analyzed to determine the motion type and the percentage of time the prostate was
      displaced >/= 3, 5, 7, and 10 mm. Independent verification of KIM positional
      accuracy was performed using kV/MV triangulation. RESULTS: KIM was performed for 
      268 fractions. Various prostate trajectories were observed (ie, continuous target
      drift, transient excursion, stable target position, persistent excursion,
      high-frequency excursions, and erratic behavior). For all patients, 3D
      displacements of >/= 3, 5, 7, and 10 mm were observed 5.6%, 2.2%, 0.7% and 0.4%
      of the time, respectively. The average systematic accuracy of KIM was measured at
      0.46 mm. CONCLUSIONS: KIM for prostate IMAT was successfully implemented
      clinically for the first time. Key advantages of this method are (1)
      submillimeter accuracy, (2) widespread applicability, and (3) a low barrier to
      clinical implementation. A disadvantage is that KIM delivers additional imaging
      dose to the patient.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Ng, Jin Aun
AU  - Ng JA
AD  - Radiation Physics Laboratory, Sydney Medical School and Institute of Medical
      Physics, School of Physics, University of Sydney, New South Wales, Australia.
FAU - Booth, Jeremy T
AU  - Booth JT
FAU - Poulsen, Per R
AU  - Poulsen PR
FAU - Fledelius, Walther
AU  - Fledelius W
FAU - Worm, Esben Schjodt
AU  - Worm ES
FAU - Eade, Thomas
AU  - Eade T
FAU - Hegi, Fiona
AU  - Hegi F
FAU - Kneebone, Andrew
AU  - Kneebone A
FAU - Kuncic, Zdenka
AU  - Kuncic Z
FAU - Keall, Paul J
AU  - Keall PJ
LA  - eng
GR  - R01 CA093626/CA/NCI NIH HHS/United States
GR  - CI R01CA93626/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120911
PL  - United States
TA  - Int J Radiat Oncol Biol Phys
JT  - International journal of radiation oncology, biology, physics
JID - 7603616
SB  - IM
MH  - Dose Fractionation, Radiation
MH  - Fiducial Markers
MH  - Humans
MH  - Imaging, Three-Dimensional/instrumentation/*methods
MH  - Likelihood Functions
MH  - Male
MH  - *Movement
MH  - *Particle Accelerators
MH  - Prospective Studies
MH  - Prostate/*diagnostic imaging
MH  - Prostatic Neoplasms/*diagnostic imaging/*radiotherapy
MH  - Radiography
MH  - Radiotherapy Planning, Computer-Assisted/methods
MH  - Radiotherapy, Intensity-Modulated/instrumentation/*methods
PMC - PMC5357433
MID - NIHMS398496
EDAT- 2012/09/15 06:00
MHDA- 2013/01/15 06:00
CRDT- 2012/09/15 06:00
PHST- 2012/05/23 00:00 [received]
PHST- 2012/06/26 00:00 [revised]
PHST- 2012/07/21 00:00 [accepted]
PHST- 2012/09/15 06:00 [entrez]
PHST- 2012/09/15 06:00 [pubmed]
PHST- 2013/01/15 06:00 [medline]
AID - S0360-3016(12)03312-3 [pii]
AID - 10.1016/j.ijrobp.2012.07.2367 [doi]
PST - ppublish
SO  - Int J Radiat Oncol Biol Phys. 2012 Dec 1;84(5):e655-61. doi:
      10.1016/j.ijrobp.2012.07.2367. Epub 2012 Sep 11.


PMID- 22975387
OWN - NLM
STAT- MEDLINE
DCOM- 20131113
LR  - 20121102
IS  - 0965-206X (Print)
IS  - 0965-206X (Linking)
VI  - 21
IP  - 4
DP  - 2012 Nov
TI  - Ethical issues and challenges in pressure ulcer research - the research nurses'
      perspective.
PG  - 105-8
LID - 10.1016/j.jtv.2012.08.002 [doi]
LID - S0965-206X(12)00037-X [pii]
AB  - AIM OF STUDY: This paper explores the issues faced by research nurses in pressure
      ulcer research through reflection on our own practice and subsequently addresses 
      these issues through critical appraisal of the existing literature. METHODS: A
      critical reflection framework which provided an opportunity for group reflection 
      and reflexivity was adopted to guide our reflection. Focus questions were
      formulated based on our reflections and used to inform our literature review.
      Keywords used in the literature review search included 'research nurse', ethical 
      principles, ethical issues and reflection. A formal tool was used to appraise
      normative ethics articles. RESULTS: Reflection on our practice in pressure ulcer 
      research identified four main issues: informed consent, confidentiality,
      methodological uncertainties and more generally the ethical dilemma of the
      conflict between our accountability and responsibility to the patients and
      obligations to the research studies. The notion of 'power relations' was found to
      permeate our practice as research nurses at all level. Six normative ethics
      papers were retrieved and critically appraised to aid our personal and
      professional learning and development in the conduct of ethical practice as
      research nurses in pressure ulcer research through the theory of practice which
      other research nurses and/or nurse researchers used in other disciplines.
      CONCLUSIONS: Four main ethical challenges and the issue of power relation were
      highlighted. Our reflection and the appraisal of the literature provided us the
      necessary knowledge and skills to better navigate these ethical challenges in the
      future.
CI  - Copyright (c) 2012 Tissue Viability Society. Published by Elsevier Ltd. All
      rights reserved.
FAU - Choo, Jimmy
AU  - Choo J
AD  - Tissue Viability Department, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
      jimmy.choo@leedsth.nhs.uk
FAU - Blundell, Sally
AU  - Blundell S
FAU - McGinnis, Elizabeth
AU  - McGinnis E
LA  - eng
PT  - Journal Article
DEP - 20120910
PL  - England
TA  - J Tissue Viability
JT  - Journal of tissue viability
JID - 9306822
MH  - Aged
MH  - *Ethics, Research
MH  - Humans
MH  - *Nursing Research
MH  - *Pressure Ulcer
EDAT- 2012/09/15 06:00
MHDA- 2013/11/14 06:00
CRDT- 2012/09/15 06:00
PHST- 2012/05/28 00:00 [received]
PHST- 2012/08/15 00:00 [accepted]
PHST- 2012/09/15 06:00 [entrez]
PHST- 2012/09/15 06:00 [pubmed]
PHST- 2013/11/14 06:00 [medline]
AID - S0965-206X(12)00037-X [pii]
AID - 10.1016/j.jtv.2012.08.002 [doi]
PST - ppublish
SO  - J Tissue Viability. 2012 Nov;21(4):105-8. doi: 10.1016/j.jtv.2012.08.002. Epub
      2012 Sep 10.


PMID- 22974946
OWN - NLM
STAT- MEDLINE
DCOM- 20130131
LR  - 20120914
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 44
IP  - 7
DP  - 2012 Sep
TI  - Transplantation ethics: are we approaching the crossroads?
PG  - 2171-2
LID - 10.1016/j.transproceed.2012.07.111 [doi]
LID - S0041-1345(12)00809-3 [pii]
AB  - Ethical issues of organ transplantation are of extreme importance to involved
      physicians and to society. The basic principle is that the donor cannot be
      considered as a commodity; financial incentives must not occur. Regarding
      deceased-donor organ transplantations, ethical issues are related to the consent 
      for donation, determination of death, and principles of organ allocation. Living 
      donors should be healthy, giving free consent after being fully informed about
      the risks of the procedure. Transplant professionals have a double responsibility
      because they must remember about the rights of the organ recipient as well as of 
      the donor. Because of the organ shortage we commonly use organ recovery from
      donors after cardiac arrest and extend the living-donor pool, practices that may 
      influence some important ethical principles. A proper detailed determination of
      donor death is of utmost importance. The dead donor rule must be preserved.
      However category III non-heart-beating donors (so-called controlled cardiac
      arrest) raise doubts as to the time of the decision to transfer the dying (not
      yet dead) patient to the operating room to withhold supportive treatment. In
      certain centers, not quite healthy living donors are being used; they are called 
      extended-criteria or complex donors. Although organ trade is condemned, some
      workers agree to use as complete strangers donors, obviously believing in pure
      altruistic motivation of such donors without the additional incentives. Finally, 
      is the trend to consider utility in organ allocation justified? It seems that
      quite soon we may need a new transplantation ethics code that is not totally
      directed by transplant professionals exclusively to the needs of potential
      recipients.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Rowinski, W
AU  - Rowinski W
AD  - Polish Union for Transplantation Medicine, Warsaw, Poland; Department of Surgery,
      University of Warmia and Mazury, Olsztyn, Poland. wrowins@gmail.com
FAU - Paczek, L
AU  - Paczek L
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - *Ethics
MH  - Humans
MH  - Informed Consent
MH  - Living Donors
MH  - *Transplantation
EDAT- 2012/09/15 06:00
MHDA- 2013/02/01 06:00
CRDT- 2012/09/15 06:00
PHST- 2012/09/15 06:00 [entrez]
PHST- 2012/09/15 06:00 [pubmed]
PHST- 2013/02/01 06:00 [medline]
AID - S0041-1345(12)00809-3 [pii]
AID - 10.1016/j.transproceed.2012.07.111 [doi]
PST - ppublish
SO  - Transplant Proc. 2012 Sep;44(7):2171-2. doi: 10.1016/j.transproceed.2012.07.111.


PMID- 22974934
OWN - NLM
STAT- MEDLINE
DCOM- 20130131
LR  - 20120914
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 44
IP  - 7
DP  - 2012 Sep
TI  - Decrease in cold ischemic times as a result of protocol changes of urgent
      immunogenetic testing during cadaveric kidney transplantation in Hungary.
PG  - 2132-5
LID - 10.1016/j.transproceed.2012.07.130 [doi]
LID - S0041-1345(12)00828-7 [pii]
AB  - BACKGROUND: Based on national ethics committee permission, the procedure of
      urgent immunogenetics testing prior to cadaveric kidney transplantation was
      changed in Hungary from January 1, 2011 allowing HLA typing of the donor and
      prospective crossmatching using peripheral blood samples from the donor prior to 
      the definitive declaration of brain death. The aim of the current study was to
      compare key indicators of transplantation primarily cold ischemic time [CIT],
      between time periods with outcomes. METHODS: The following indicators were
      systematically collected prospectively and retrospectively for each deceased
      heart-beating donor transplantation between January 1, 2010 and October 31, 2010 
      (n = 114) versus January 1, 2011 and October 31, 2011 (n = 91): CIT for the first
      and second kidney; laboratory turnaround times (TAT), and time for final
      preparation of the selected recipient. RESULTS: As a result of the new procedure,
      the CIT for the first kidney decreased from 16.5 +/- 3.5 to 12.4 +/- 3.2 hours (P
      < .001). Similarly, for the second kidney the parameters were a 19.8 +/- 3.4
      versus 16.0 +/- 3.8 hours (P < .001). As a consequence of more hands-on time in
      the laboratory, the TAT increased from 5.6 +/- 0.8 hours to 7.2 +/- 1.1 hours
      (TAT1) followed by an additional 4.2 +/- 1.0 hours (TAT2). We also compared the
      times necessary for preparation of immunologically suitable recipients for
      transplantation, namely, 9.5 +/- 2.3 hours in the earlier system, increasing to
      15.5 +/- 4.3 hours during the new procedure. CONCLUSION: As a consequence of the 
      procedural change, the CIT parameter decreased significantly for both kidneys,
      which may have contributed to improved short-term outcomes of transplantation.
      The time available for final preparation of selected recipients was increased
      allowing improvements in CIT.
CI  - Copyright (c) 2012. Published by Elsevier Inc.
FAU - Inotai, D
AU  - Inotai D
AD  - Laboratory of Transplantation Immunogenetics, Hungarian Blood Transfusion
      Service, Budapest, Hungary. inotai.dora@ovsz.hu
FAU - Boros-Major, A
AU  - Boros-Major A
FAU - Illes, Z
AU  - Illes Z
FAU - Szilvasi, A
AU  - Szilvasi A
FAU - Nagy, G
AU  - Nagy G
FAU - Rajczy, K
AU  - Rajczy K
FAU - Chmel, R
AU  - Chmel R
FAU - Langer, R M
AU  - Langer RM
FAU - Tordai, A
AU  - Tordai A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - *Cadaver
MH  - *Cold Temperature
MH  - Humans
MH  - Hungary
MH  - *Ischemia
MH  - *Kidney Transplantation
MH  - *Organ Preservation
MH  - Prospective Studies
EDAT- 2012/09/15 06:00
MHDA- 2013/02/01 06:00
CRDT- 2012/09/15 06:00
PHST- 2012/09/15 06:00 [entrez]
PHST- 2012/09/15 06:00 [pubmed]
PHST- 2013/02/01 06:00 [medline]
AID - S0041-1345(12)00828-7 [pii]
AID - 10.1016/j.transproceed.2012.07.130 [doi]
PST - ppublish
SO  - Transplant Proc. 2012 Sep;44(7):2132-5. doi: 10.1016/j.transproceed.2012.07.130.


PMID- 22974875
OWN - NLM
STAT- MEDLINE
DCOM- 20130131
LR  - 20120914
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 44
IP  - 7
DP  - 2012 Sep
TI  - Liver autotransplantation for the treatment of unresectable hepatic metastasis:
      an uncommon indication-a case report.
PG  - 1930-3
LID - 10.1016/j.transproceed.2012.06.032 [doi]
LID - S0041-1345(12)00575-1 [pii]
AB  - Ex situ ex vivo liver surgery represents a method to expand the surgical
      indications to treat otherwise unresectable liver tumors. We report the case of a
      38-year old woman with hepatic metastasis from a pancreatoblastoma that was
      judged to be unresectable due to the involvement of the three hepatic veins. To
      treat the primary tumor, she underwent a pancreaticoduodenectomy, adjuvant
      chemotherapy, and thermal ablation of a liver metastasis. After appropriate
      preoperative study and with the permission of the ethics committee, she underwent
      ex situ ex vivo liver resection. The hepatectomy was performed by removing the
      whole liver en bloc with the retrohepatic vena cava. The inferior vena cava was
      reconstructed by interposition of a prosthetic graft. The ex situ ex vivo hepatic
      resection, a left hepatic lobectomy included the lesion in segments 1-5-7-8. The 
      two hepatic veins were reconstructed using patches of saphenous vein. The organ
      was preserved continuously for 6 hours using hypothermic perfusion with 4 degrees
      C Celsior solution. The liver was then reimplanted performing an anastomosis
      between the reconstructed hepatic veins and the caval prostheses. The patient was
      discharged at postoperative day 22 and is currently disease-free at 8 months
      after surgery and 44 months after the initial diagnosis. Ex situ, ex vivo liver
      surgery offers an additional option for patients with both primary and secondary 
      liver tumors considered to be unresectable using traditional surgical approaches.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Gringeri, E
AU  - Gringeri E
AD  - Unita di Chirurgia Epatobiliare e Centro Trapianto Epatico, Dipartimento
      assistenziale di Chirurgia Generale e Trapianti d'Organo, Universita degli Studi 
      di Padova, Padova, Italy. enrico.gringeri@unipd.it
FAU - Polacco, M
AU  - Polacco M
FAU - D'Amico, F E
AU  - D'Amico FE
FAU - Bassi, D
AU  - Bassi D
FAU - Boetto, R
AU  - Boetto R
FAU - Tuci, F
AU  - Tuci F
FAU - Bonsignore, P
AU  - Bonsignore P
FAU - Noaro, G
AU  - Noaro G
FAU - D'Amico, F
AU  - D'Amico F
FAU - Vitale, A
AU  - Vitale A
FAU - Feltracco, P
AU  - Feltracco P
FAU - Barbieri, S
AU  - Barbieri S
FAU - Neri, D
AU  - Neri D
FAU - Zanus, G
AU  - Zanus G
FAU - Cillo, U
AU  - Cillo U
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - Adult
MH  - Combined Modality Therapy
MH  - Female
MH  - Humans
MH  - Liver Neoplasms/*secondary/*surgery
MH  - *Liver Transplantation
MH  - Pancreatic Neoplasms/drug therapy/*pathology/surgery
EDAT- 2012/09/15 06:00
MHDA- 2013/02/01 06:00
CRDT- 2012/09/15 06:00
PHST- 2012/09/15 06:00 [entrez]
PHST- 2012/09/15 06:00 [pubmed]
PHST- 2013/02/01 06:00 [medline]
AID - S0041-1345(12)00575-1 [pii]
AID - 10.1016/j.transproceed.2012.06.032 [doi]
PST - ppublish
SO  - Transplant Proc. 2012 Sep;44(7):1930-3. doi: 10.1016/j.transproceed.2012.06.032.


PMID- 22974855
OWN - NLM
STAT- MEDLINE
DCOM- 20130131
LR  - 20151119
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 44
IP  - 7
DP  - 2012 Sep
TI  - A preliminary European study on extended-criteria liver donation and transplant
      recipient consent.
PG  - 1857-8
LID - 10.1016/j.transproceed.2012.05.065 [doi]
LID - S0041-1345(12)00530-1 [pii]
AB  - ELPAT (Ethical, Legal, and Psychologic Aspects of Organ Transplantation)
      coordinated the distribution to European liver transplant centers of an
      electronic questionnaire regarding the definition of extended-criteria liver
      donation (ECD) and its implication for informed consent by transplant recipients.
      Completed questionnaires were received from 30 centers in 13 countries including 
      28 who accepted ECD liver donors. The criteria to define a liver donor as ECD
      were: steatosis in 24 centers (85%); age up to 80 years in 23 centers (82%);
      serum sodium >165 mmol/L in 17 centers (60%); ICU stay with ventilation >7 days
      in 16 centers (57%); serum glutamic oxaloacetic transaminas >90 U/L, in 12
      centres (42%); body mass index >30 kg/m(2) in 10 centers (35%); serum glutamate
      pyruvate transaminase >105 U/L in 10 centers (35%); serum bilirubin >3 mg/dL in
      10 centers (35%); and other criteria in 13 centers (46%). Twenty-three centers
      informed the transplant candidate of the ECD status of the donor: 10 (43%) when
      the patient registered for transplantation, 3 (14%) when an ECD liver became
      available, and 10 (43%) on both occasions. Ten centers required the liver
      transplant candidate to sign a special consent form. Ten centers informed the
      potential recipient of the donor's serology. Only 3 centers informed the
      potential recipient of any high-risk behavior of the donor.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Bruzzone, P
AU  - Bruzzone P
AD  - Sapienza Universita di Roma, Rome, Italy. paolo.bruzzone@fastwebnet.it
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - Europe
MH  - Humans
MH  - *Informed Consent
MH  - Intensive Care Units
MH  - Liver Function Tests
MH  - *Liver Transplantation
MH  - Living Donors
MH  - Surveys and Questionnaires
EDAT- 2012/09/15 06:00
MHDA- 2013/02/01 06:00
CRDT- 2012/09/15 06:00
PHST- 2012/09/15 06:00 [entrez]
PHST- 2012/09/15 06:00 [pubmed]
PHST- 2013/02/01 06:00 [medline]
AID - S0041-1345(12)00530-1 [pii]
AID - 10.1016/j.transproceed.2012.05.065 [doi]
PST - ppublish
SO  - Transplant Proc. 2012 Sep;44(7):1857-8. doi: 10.1016/j.transproceed.2012.05.065.


PMID- 22974847
OWN - NLM
STAT- MEDLINE
DCOM- 20130131
LR  - 20220410
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 44
IP  - 7
DP  - 2012 Sep
TI  - Extracorporeal lung perfusion and ventilation to improve donor lung function and 
      increase the number of organs available for transplantation.
PG  - 1826-9
LID - 10.1016/j.transproceed.2012.06.023 [doi]
LID - S0041-1345(12)00566-0 [pii]
AB  - INTRODUCTION: Ex vivo lung perfusion (EVLP) has been validated as a valuable
      technique to increase the pool of organs available for lung transplantation.
      MATERIAL AND METHODS: After a preclinical experience, we obtained permission from
      the Ethics Committee of our institution to transplant lungs after EVLP
      reconditioning. ABO compatibility, size match, and donor arterial oxygen pressure
      (PaO(2))/fraction of inspired oxygen (FiO(2)) </= 300 mm Hg were considered to be
      inclusion criteria, whereas the presence of chest trauma and lung contusion,
      evidence of gastric content aspiration, pneumonia, sepsis, or systemic disease
      were exclusion criteria. We only considered subjects on an extra corporeal
      membrane oxygenation (ECMO) bridge to transplantation with rapid functional
      deterioration. Using Steen solution with packed red blood cells oxygenated with
      21% O(2), 5% to 7% CO(2) was delivered, targeted with a blood flow of
      approximately 40% predicted cardiac output. Once normothermic, the lungs were
      ventilated with a tidal volume of 7 mL/kg a PEEP of 5 cmH(2)O and a respiratory
      rate of 7 bpm. Lungs were considered to be suitable for transplantation if well
      oxygenated [P(v-a) O(2) > 350 mm Hg on FiO(2) 100%], in the absence of
      deterioration of pulmonary vascular resistance and lung mechanics over the
      perfusion time. RESULTS: From March to September 2011, six lung transplantations 
      were performed, including two with EVLP. The functional outcomes were similar
      between groups: at T72 posttransplantation, the median PaO(2)/FiO(2) were 306 mm 
      Hg (range, 282 to 331 mm Hg) and 323 mm Hg (range, 270 to 396 mm Hg) (P = 1, EVLP
      versus conventional). Intensive care unit ICU and hospital length of stay were
      similar (P = .533 and P = .663, respectively) with no mortality at 60 days in
      both groups. EVLP donors were older (49 +/- 6 y versus 21 +/- 7 y, P < .05), less
      well oxygenated (184 +/- 6 mm Hg versus 570 +/- 30, P < .05), displaying higher
      Oto scores (9.5 +/- 0.7 versus 1.7 +/- 1.5, P < .05). CONCLUSIONS: The first 6
      months of the EVLP program allowed us to increase the number of organs available 
      for transplantation with short-term outcomes comparable to conventional
      transplantations.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Valenza, F
AU  - Valenza F
AD  - Dipartimento di Anestesia, Terapia Intensiva e Subintensiva e Terapia del Dolore,
      Universita degli Studi di Milano, Milano, Italy. franco.valenza@unimi.it
FAU - Rosso, L
AU  - Rosso L
FAU - Gatti, S
AU  - Gatti S
FAU - Coppola, S
AU  - Coppola S
FAU - Froio, S
AU  - Froio S
FAU - Colombo, J
AU  - Colombo J
FAU - Dossi, R
AU  - Dossi R
FAU - Pizzocri, M
AU  - Pizzocri M
FAU - Salice, V
AU  - Salice V
FAU - Nosotti, M
AU  - Nosotti M
FAU - Reggiani, P
AU  - Reggiani P
FAU - Tosi, D
AU  - Tosi D
FAU - Palleschi, A
AU  - Palleschi A
FAU - Pappalettera, M
AU  - Pappalettera M
FAU - Ferrero, S
AU  - Ferrero S
FAU - Perazzoli, A
AU  - Perazzoli A
FAU - Costantini, D
AU  - Costantini D
FAU - Scalamogna, M
AU  - Scalamogna M
FAU - Rossi, G
AU  - Rossi G
FAU - Colombo, C
AU  - Colombo C
FAU - Santambrogio, L
AU  - Santambrogio L
FAU - Gattinoni, L
AU  - Gattinoni L
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - Adult
MH  - *Extracorporeal Membrane Oxygenation
MH  - Female
MH  - Humans
MH  - Lung/*physiology
MH  - *Lung Transplantation
MH  - Male
MH  - Middle Aged
MH  - Respiratory Function Tests
MH  - *Tissue Donors
EDAT- 2012/09/15 06:00
MHDA- 2013/02/01 06:00
CRDT- 2012/09/15 06:00
PHST- 2012/09/15 06:00 [entrez]
PHST- 2012/09/15 06:00 [pubmed]
PHST- 2013/02/01 06:00 [medline]
AID - S0041-1345(12)00566-0 [pii]
AID - 10.1016/j.transproceed.2012.06.023 [doi]
PST - ppublish
SO  - Transplant Proc. 2012 Sep;44(7):1826-9. doi: 10.1016/j.transproceed.2012.06.023.


PMID- 22974843
OWN - NLM
STAT- MEDLINE
DCOM- 20130131
LR  - 20120914
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 44
IP  - 7
DP  - 2012 Sep
TI  - Kidney allocation for transplantation: some aspects of ethics and comparative
      law.
PG  - 1812-4
LID - 10.1016/j.transproceed.2012.05.059 [doi]
LID - S0041-1345(12)00524-6 [pii]
AB  - The allocation of organs is a crucial ethical issue. The importance attached to
      different allocation criteria differs considerably among the various national and
      international organizations. The balance between justice-centered and
      utility-centered systems is shifting and there are signs of a possible swing away
      from systems centered mainly on waiting times to others centered mainly on
      criteria of utility. This evolution is very significant and seems to run counter 
      to the main stream of modern bioethics. Examples from different national policies
      are given herein. Particular attention is given to Europe, where national
      bioethics committees have tended to ignore the aspect of organ allocation. By
      overemphasizing the issues related to informed consent, the ethical challenges
      arising from the problems of resource allocation are often relegated to second
      place.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Petrini, C
AU  - Petrini C
AD  - Bioethics Unit, National Institute of Health [Istituto Superiore di Sanita],
      Rome, Italy. carlo.petrini@iss.it
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - *Ethics
MH  - *Health Care Rationing
MH  - Humans
MH  - *Kidney Transplantation
EDAT- 2012/09/15 06:00
MHDA- 2013/02/01 06:00
CRDT- 2012/09/15 06:00
PHST- 2012/09/15 06:00 [entrez]
PHST- 2012/09/15 06:00 [pubmed]
PHST- 2013/02/01 06:00 [medline]
AID - S0041-1345(12)00524-6 [pii]
AID - 10.1016/j.transproceed.2012.05.059 [doi]
PST - ppublish
SO  - Transplant Proc. 2012 Sep;44(7):1812-4. doi: 10.1016/j.transproceed.2012.05.059.


PMID- 22974432
OWN - NLM
STAT- MEDLINE
DCOM- 20121213
LR  - 20120914
IS  - 1473-0782 (Electronic)
IS  - 1362-5187 (Linking)
VI  - 17
IP  - 5
DP  - 2012 Oct
TI  - Social and ethical determinants of sexuality: 4. Sexuality and families.
PG  - 329-39
LID - 10.3109/13625187.2012.702810 [doi]
AB  - OBJECTIVES: To investigate the evolving relationship between sexuality and family
      formation. New family units exist today whose impact on society needs to be
      explored. METHODS: For each main area researched (anthropology, biology,
      sociology, sexology, ethics) we identified articles dealing with family
      formation, sexuality and reproduction using PubMed, ScienceDirect, Google,
      religious websites and texts. RESULTS: The three monotheistic religions and the
      cultures derived from these have considered sexuality as focused on reproduction.
      Presently, sexuality has acquired new dimensions, independent from reproduction, 
      as contraception and IVF have separated procreation and sexuality. Thus, the very
      concept of family has been expanded and so-called 'unusual families' have proved 
      not to be a danger per se for children born and raised within them. CONCLUSIONS: 
      Human sexuality has moved away from having a purely reproductive function, but
      remains a powerful bond keeping families together, irrespective of the gender
      identity and the biological links of their members. Even among traditional
      societies, different types of families exist and the situation has become more
      complex as technical developments have made parenthood possible for people who in
      the past were excluded from it.
FAU - Benagiano, Giuseppe
AU  - Benagiano G
AD  - Department of Gynaecology, Obstetrics and Urology, Sapienza University of Rome,
      Italy. Giuseppe.Benagiano@uniroma1.it
FAU - Carrara, Sabina
AU  - Carrara S
FAU - Filippi, Valentina
AU  - Filippi V
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur J Contracept Reprod Health Care
JT  - The European journal of contraception & reproductive health care : the official
      journal of the European Society of Contraception
JID - 9712127
SB  - IM
MH  - Contraception/ethics/methods/statistics & numerical data/trends
MH  - *Family Characteristics
MH  - *Family Relations
MH  - Female
MH  - Heterosexuality
MH  - Homosexuality, Female
MH  - Homosexuality, Male
MH  - Humans
MH  - Infertility/therapy
MH  - Male
MH  - Marriage/trends
MH  - *Nuclear Family
MH  - Parent-Child Relations
MH  - Parenting/trends
MH  - *Religion and Medicine
MH  - Reproduction/ethics
MH  - Reproductive Techniques, Assisted
MH  - Sex Characteristics
MH  - Sexuality/*ethics
MH  - Social Change
MH  - Sterilization, Reproductive/ethics/methods/trends
MH  - Surrogate Mothers
MH  - Third-Party Consent
EDAT- 2012/09/15 06:00
MHDA- 2012/12/14 06:00
CRDT- 2012/09/15 06:00
PHST- 2012/09/15 06:00 [entrez]
PHST- 2012/09/15 06:00 [pubmed]
PHST- 2012/12/14 06:00 [medline]
AID - 10.3109/13625187.2012.702810 [doi]
PST - ppublish
SO  - Eur J Contracept Reprod Health Care. 2012 Oct;17(5):329-39. doi:
      10.3109/13625187.2012.702810.


PMID- 22974272
OWN - NLM
STAT- MEDLINE
DCOM- 20131202
LR  - 20211021
IS  - 1747-5341 (Electronic)
IS  - 1747-5341 (Linking)
VI  - 7
DP  - 2012 Sep 13
TI  - The right to practice medicine without repercussions: ethical issues in times of 
      political strife.
PG  - 11
LID - 10.1186/1747-5341-7-11 [doi]
AB  - This commentary examines the incursion on the neutrality of medical personnel now
      taking place as part of the human rights crises in Bahrain and Syria, and the
      ethical dilemmas which these incursions place not only in front of physicians
      practicing in those nations, but in front of the international community as a
      whole.In Bahrain, physicians have recently received harsh prison terms,
      apparently for treating demonstrators who clashed with government forces. In
      Syria, physicians are under the same political pressure to avoid treating
      political demonstrators or to act as informants against their own patients,
      turning them in to government authorities. This pressure has been severe, to the 
      point that some physicians have become complicit in the abuse of patients who
      were also political demonstrators.This paper posits that physicians in certain
      countries in the Middle East during the "Arab Spring," specifically Syria and
      Bahrain, are being used as both political pawns and political weapons in clear
      violation of Geneva Convention and World Medical Association guidelines, and that
      this puts them into the most extreme sort of "dual loyalty" dilemma. They are
      being forced to choose between their own safety and well-being and that of their 
      patients - a negative sum scenario wherein there is no optimal choice. As such,
      an international call for a United Nations inquiry must be made in order to
      protect the neutrality of medical care and personnel during times of armed
      conflict.
FAU - Hathout, Leith
AU  - Hathout L
AD  - Department of Biology, Stanford University, P.O. Box 11042, Stanford, CA
      9430--1042, USA. lhathout@stanford.edu
LA  - eng
PT  - Editorial
DEP - 20120913
PL  - England
TA  - Philos Ethics Humanit Med
JT  - Philosophy, ethics, and humanities in medicine : PEHM
JID - 101258058
SB  - IM
MH  - Bahrain
MH  - *Civil Disorders
MH  - *Complicity
MH  - *Conflict, Psychological
MH  - Dissent and Disputes
MH  - *Ethics, Medical
MH  - *Human Rights
MH  - Humans
MH  - Middle East
MH  - Physician-Patient Relations/*ethics
MH  - Physicians/*ethics
MH  - Syria
MH  - *Warfare
PMC - PMC3511879
EDAT- 2012/09/15 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/09/15 06:00
PHST- 2011/11/07 00:00 [received]
PHST- 2012/07/12 00:00 [accepted]
PHST- 2012/09/15 06:00 [entrez]
PHST- 2012/09/15 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 1747-5341-7-11 [pii]
AID - 10.1186/1747-5341-7-11 [doi]
PST - epublish
SO  - Philos Ethics Humanit Med. 2012 Sep 13;7:11. doi: 10.1186/1747-5341-7-11.


PMID- 22974028
OWN - NLM
STAT- MEDLINE
DCOM- 20121119
LR  - 20120914
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 12
IP  - 10
DP  - 2012
TI  - Surrogate decision making in the internet age.
PG  - 28-33
LID - 10.1080/15265161.2012.708088 [doi]
AB  - The computer revolution has had an enormous effect on all aspects of the practice
      of medicine, yet little thought has been given to the role of social media in
      identifying treatment choices for incompetent patients. We are currently living
      in the "Internet age" and many people have integrated social media into all
      aspects of their lives. As use becomes more prevalent, and as users age, social
      media are more likely to be viewed as a source of information regarding medical
      care preferences. This article explores the ethical and legal issues raised by
      the use of social media in surrogate decision making.
FAU - Berg, Jessica
AU  - Berg J
AD  - Case Western Reserve University, Cleveland, OH 44106, USA. jessica.berg@case.edu
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CIN - Am J Bioeth. 2012;12(10):34-6. PMID: 22974029
CIN - Am J Bioeth. 2012;12(10):36-7. PMID: 22974030
CIN - Am J Bioeth. 2012;12(10):38-9. PMID: 22974031
CIN - Am J Bioeth. 2012;12(10):39-41. PMID: 22974032
CIN - Am J Bioeth. 2012;12(10):41-3. PMID: 22974033
CIN - Am J Bioeth. 2012;12(10):43-5. PMID: 22974034
CIN - Am J Bioeth. 2012;12(10):45-7. PMID: 22974035
CIN - Am J Bioeth. 2012;12(10):47-9. PMID: 22974036
CIN - Am J Bioeth. 2012;12(10):49-50. PMID: 22974037
CIN - Am J Bioeth. 2012;12(10):51. PMID: 22974038
CIN - Am J Bioeth. 2012;12(10):W1-2. PMID: 22974042
MH  - *Advance Directives
MH  - Choice Behavior/ethics
MH  - Decision Making/*ethics
MH  - Humans
MH  - Internet
MH  - Male
MH  - *Mental Competency
MH  - Middle Aged
MH  - *Social Media
MH  - Third-Party Consent/*ethics
MH  - Time Factors
EDAT- 2012/09/15 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/09/15 06:00
PHST- 2012/09/15 06:00 [entrez]
PHST- 2012/09/15 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1080/15265161.2012.708088 [doi]
PST - ppublish
SO  - Am J Bioeth. 2012;12(10):28-33. doi: 10.1080/15265161.2012.708088.


PMID- 22973819
OWN - NLM
STAT- MEDLINE
DCOM- 20130507
LR  - 20151119
IS  - 1464-5351 (Electronic)
IS  - 1369-1058 (Linking)
VI  - 14
IP  - 10
DP  - 2012
TI  - Motivations for, and perceptions and experiences of participating in, a cluster
      randomised controlled trial of a HIV-behavioural intervention in rural South
      Africa.
PG  - 1167-82
LID - 10.1080/13691058.2012.717305 [doi]
AB  - Empirical research on ethical issues in HIV-prevention and gender-based violence 
      research, critical for honing ethical and safety guidelines, is limited. In this 
      paper we describe South African young people's motivations for participating in
      randomised controlled trial, the prevalence of negative occurrences,
      participation regrets and associated factors. This trial partly followed, but
      also deviated from, the WHO safety guidelines for research on violence against
      women. A total of 1085 women and 985 men provided information two years after the
      trial start. Most participated for HIV testing and to help their community. Fewer
      reported motivation by the financial incentive. Minor adverse events included
      upset from questions on childhood experiences and arguments at home with
      siblings. Just under 1 in 10 (8.1% women, 9.8% men) regretted participation.
      Factors were associated with this were keeping some questions secret from their
      partners, feeling sad about questions on childhood, quarrelling at home and, for 
      women, being motivated by the incentive. Men who had been physically violent to a
      partner were twice as likely to regret participation. There were no recorded
      adverse effects from the deviations from the ethical guidelines. Participation
      regrets mostly stemmed from problems in participants' families preceding the
      research. There was no evidence that the research had been unsafe.
FAU - Jewkes, Rachel
AU  - Jewkes R
AD  - Gender and Health Research Unit, South Africa Medical Research Council, Pretoria,
      South Africa.
FAU - Sikweyiya, Yandisa
AU  - Sikweyiya Y
FAU - Nduna, Mzikazi
AU  - Nduna M
FAU - Shai, Nwabisa Jama
AU  - Shai NJ
FAU - Dunkle, Kristin
AU  - Dunkle K
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20120914
PL  - England
TA  - Cult Health Sex
JT  - Culture, health & sexuality
JID - 100883416
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cluster Analysis
MH  - Empirical Research
MH  - Female
MH  - HIV Infections/*prevention & control
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Male
MH  - *Motivation
MH  - Research Subjects/*psychology
MH  - *Sexual Behavior
MH  - South Africa
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2012/09/15 06:00
MHDA- 2013/05/08 06:00
CRDT- 2012/09/15 06:00
PHST- 2012/09/15 06:00 [entrez]
PHST- 2012/09/15 06:00 [pubmed]
PHST- 2013/05/08 06:00 [medline]
AID - 10.1080/13691058.2012.717305 [doi]
PST - ppublish
SO  - Cult Health Sex. 2012;14(10):1167-82. doi: 10.1080/13691058.2012.717305. Epub
      2012 Sep 14.


PMID- 22973790
OWN - NLM
STAT- MEDLINE
DCOM- 20121105
LR  - 20120914
IS  - 0883-5381 (Print)
IS  - 0883-5381 (Linking)
VI  - 27
IP  - 5
DP  - 2012 Sep-Oct
TI  - The ethics of mission and margin.
PG  - 30-2, 34, 36 passim
FAU - Voges, Nicole D
AU  - Voges ND
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Healthc Exec
JT  - Healthcare executive
JID - 8612808
MH  - Delivery of Health Care/*economics/*ethics
MH  - Health Facilities/economics
MH  - Health Facility Administrators/*ethics
MH  - Humans
MH  - Organizational Objectives/economics
MH  - Professional Role
MH  - United States
EDAT- 2012/09/15 06:00
MHDA- 2012/11/06 06:00
CRDT- 2012/09/15 06:00
PHST- 2012/09/15 06:00 [entrez]
PHST- 2012/09/15 06:00 [pubmed]
PHST- 2012/11/06 06:00 [medline]
PST - ppublish
SO  - Healthc Exec. 2012 Sep-Oct;27(5):30-2, 34, 36 passim.


PMID- 22973216
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1662-5161 (Electronic)
IS  - 1662-5161 (Linking)
VI  - 6
DP  - 2012
TI  - Explicit and implicit issues in the developmental cognitive neuroscience of
      social inequality.
PG  - 254
LID - 10.3389/fnhum.2012.00254 [doi]
AB  - The appearance of developmental cognitive neuroscience (DCN) in the socioeconomic
      status (SES) research arena is hugely transformative, but challenging. We review 
      challenges rooted in the implicit and explicit assumptions informing this newborn
      field. We provide balanced theoretical alternatives on how hypothesized
      psychological processes map onto the brain (e.g., problem of localization) and
      how experimental phenomena at multiple levels of analysis (e.g., behavior,
      cognition and the brain) could be related. We therefore examine unclear issues
      regarding the existing perspectives on poverty and their relationships with low
      SES, the evidence of low-SES adaptive functioning, historical precedents of the
      "alternate pathways" (neuroplasticity) interpretation of learning disabilities
      related to low-SES and the notion of deficit, issues of "normativity" and
      validity in findings of neurocognitive differences between children from
      different SES, and finally alternative interpretations of the complex
      relationship between IQ and SES. Particularly, we examine the extent to which the
      available laboratory results may be interpreted as showing that cognitive
      performance in low-SES children reflects cognitive and behavioral deficits as a
      result of growing up in specific environmental or cultural contexts, and how the 
      experimental findings should be interpreted for the design of different types of 
      interventions-particularly those related to educational practices-or translated
      to the public-especially the media. Although a cautionary tone permeates many
      studies, still, a potential deficit attribution-i.e., low-SES is associated with 
      cognitive and behavioral developmental deficits-seems almost an inevitable
      implicit issue with ethical implications. Finally, we sketch the agenda for an
      ecological DCN, suggesting recommendations to advance the field, specifically, to
      minimize equivocal divulgation and maximize ethically responsible translation.
FAU - D'Angiulli, Amedeo
AU  - D'Angiulli A
AD  - Department of Neuroscience, Carleton University Ottawa, ON, Canada.
FAU - Lipina, Sebastian J
AU  - Lipina SJ
FAU - Olesinska, Alice
AU  - Olesinska A
LA  - eng
PT  - Journal Article
DEP - 20120906
PL  - Switzerland
TA  - Front Hum Neurosci
JT  - Frontiers in human neuroscience
JID - 101477954
PMC - PMC3434357
OTO - NOTNLM
OT  - EEG
OT  - ERPs
OT  - fMRI
OT  - neurocognitive processes
OT  - neuroimaging
OT  - socioeconomic status
OT  - theoretical neuroscience
EDAT- 2012/09/14 06:00
MHDA- 2012/09/14 06:01
CRDT- 2012/09/14 06:00
PHST- 2012/05/11 00:00 [received]
PHST- 2012/08/20 00:00 [accepted]
PHST- 2012/09/14 06:00 [entrez]
PHST- 2012/09/14 06:00 [pubmed]
PHST- 2012/09/14 06:01 [medline]
AID - 10.3389/fnhum.2012.00254 [doi]
PST - epublish
SO  - Front Hum Neurosci. 2012 Sep 6;6:254. doi: 10.3389/fnhum.2012.00254. eCollection 
      2012.


PMID- 22972844
OWN - NLM
STAT- MEDLINE
DCOM- 20130128
LR  - 20211021
IS  - 1946-6242 (Electronic)
IS  - 1946-6234 (Linking)
VI  - 4
IP  - 151
DP  - 2012 Sep 12
TI  - Anthrax vaccine-induced antibodies provide cross-species prediction of survival
      to aerosol challenge.
PG  - 151ra126
LID - 10.1126/scitranslmed.3004073 [doi]
AB  - Because clinical trials to assess the efficacy of vaccines against anthrax are
      not ethical or feasible, licensure for new anthrax vaccines will likely involve
      the Food and Drug Administration's "Animal Rule," a set of regulations that allow
      approval of products based on efficacy data only in animals combined with
      immunogenicity and safety data in animals and humans. U.S. government-sponsored
      animal studies have shown anthrax vaccine efficacy in a variety of settings. We
      examined data from 21 of those studies to determine whether an immunological
      bridge based on lethal toxin neutralization activity assay (TNA) can predict
      survival against an inhalation anthrax challenge within and across species and
      genera. The 21 studies were classified into 11 different settings, each of which 
      had the same animal species, vaccine type and formulation, vaccination schedule, 
      time of TNA measurement, and challenge time. Logistic regression models
      determined the contribution of vaccine dilution dose and TNA on prediction of
      survival. For most settings, logistic models using only TNA explained more than
      75% of the survival effect of the models with dose additionally included.
      Cross-species survival predictions using TNA were compared to the actual survival
      and shown to have good agreement (Cohen's kappa ranged from 0.55 to 0.78). In one
      study design, cynomolgus macaque data predicted 78.6% survival in rhesus macaques
      (actual survival, 83.0%) and 72.6% in rabbits (actual survival, 64.6%). These
      data add support for the use of TNA as an immunological bridge between species to
      extrapolate data in animals to predict anthrax vaccine effectiveness in humans.
FAU - Fay, Michael P
AU  - Fay MP
AD  - Biostatistics Research Branch, National Institute of Allergy and Infectious
      Diseases, 6700B Rockledge Drive, Bethesda, MD 20892-7630, USA. mfay@niaid.nih.gov
FAU - Follmann, Dean A
AU  - Follmann DA
FAU - Lynn, Freyja
AU  - Lynn F
FAU - Schiffer, Jarad M
AU  - Schiffer JM
FAU - Stark, Gregory V
AU  - Stark GV
FAU - Kohberger, Robert
AU  - Kohberger R
FAU - Quinn, Conrad P
AU  - Quinn CP
FAU - Nuzum, Edwin O
AU  - Nuzum EO
LA  - eng
GR  - N01-AI-30061/AI/NIAID NIH HHS/United States
GR  - 200-2000-100065/PHS HHS/United States
GR  - Z99 AI999999/Intramural NIH HHS/United States
GR  - N01AI25494/AI/NIAID NIH HHS/United States
GR  - N01AI30061/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Sci Transl Med
JT  - Science translational medicine
JID - 101505086
RN  - 0 (Aerosols)
RN  - 0 (Anthrax Vaccines)
RN  - 0 (Antibodies, Bacterial)
SB  - IM
CIN - Sci Transl Med. 2012 Sep 12;4(151):151ps15. PMID: 22972841
MH  - Aerosols
MH  - Animals
MH  - Anthrax/immunology/*mortality/*prevention & control
MH  - Anthrax Vaccines/*immunology/*therapeutic use
MH  - Antibodies, Bacterial/*immunology
MH  - Macaca mulatta
MH  - Rabbits
PMC - PMC3668972
MID - NIHMS465270
EDAT- 2012/09/14 06:00
MHDA- 2013/01/29 06:00
CRDT- 2012/09/14 06:00
PHST- 2012/09/14 06:00 [entrez]
PHST- 2012/09/14 06:00 [pubmed]
PHST- 2013/01/29 06:00 [medline]
AID - 4/151/151ra126 [pii]
AID - 10.1126/scitranslmed.3004073 [doi]
PST - ppublish
SO  - Sci Transl Med. 2012 Sep 12;4(151):151ra126. doi: 10.1126/scitranslmed.3004073.


PMID- 22972043
OWN - NLM
STAT- MEDLINE
DCOM- 20121030
LR  - 20211021
IS  - 1469-493X (Electronic)
IS  - 1361-6137 (Linking)
IP  - 9
DP  - 2012 Sep 12
TI  - Planned hospital birth versus planned home birth.
PG  - CD000352
LID - 10.1002/14651858.CD000352.pub2 [doi]
AB  - BACKGROUND: Observational studies of increasingly better quality and in different
      settings suggest that planned home birth in many places can be as safe as planned
      hospital birth and with less intervention and fewer complications. This is an
      update of a Cochrane review first published in 1998. OBJECTIVES: To assess the
      effects of planned hospital birth compared with planned home birth in selected
      low-risk women, assisted by an experienced midwife with collaborative medical
      back up in case transfer should be necessary. SEARCH METHODS: We searched the
      Cochrane Pregnancy and Childbirth Group's Trials Register (30 March 2012) and
      contacted editors and authors involved with possible trials. SELECTION CRITERIA: 
      Randomised controlled trials comparing planned hospital birth with planned home
      birth in low-risk women as described in the objectives. DATA COLLECTION AND
      ANALYSIS: The two review authors as independently as possible assessed trial
      quality and extracted data. We contacted study authors for additional
      information. MAIN RESULTS: Two trials met the inclusion criteria but only one
      trial involving 11 women provided some outcome data and was included. The
      evidence from this trial was of moderate quality and too small to allow
      conclusions to be drawn. AUTHORS' CONCLUSIONS: There is no strong evidence from
      randomised trials to favour either planned hospital birth or planned home birth
      for low-risk pregnant women. However, the trials show that women living in areas 
      where they are not well informed about home birth may welcome ethically
      well-designed trials that would ensure an informed choice. As the quality of
      evidence in favour of home birth from observational studies seems to be steadily 
      increasing, it might be as important to prepare a regularly updated systematic
      review including observational studies as described in the Cochrane Handbook for 
      Systematic Reviews of Interventions as to attempt to set up new randomised
      controlled trials.
FAU - Olsen, Ole
AU  - Olsen O
AD  - The Research Unit for General Practice and Section of General Practice,
      Department of Public Health, University of Copenhagen,Copenhagen K, Denmark.
      ole.olsen@sund.ku.dk.ole.cph@gmail.com.
FAU - Clausen, Jette A
AU  - Clausen JA
LA  - eng
GR  - 10/4001/02/DH_/Department of Health/United Kingdom
GR  - SRP/10/4001/02/DH_/Department of Health/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20120912
PL  - England
TA  - Cochrane Database Syst Rev
JT  - The Cochrane database of systematic reviews
JID - 100909747
SB  - IM
UOF - Cochrane Database Syst Rev. 2000;(2):CD000352. PMID: 10796198
MH  - Delivery Rooms
MH  - Delivery, Obstetric/*standards
MH  - Female
MH  - Home Childbirth/*standards
MH  - *Hospitalization
MH  - Humans
MH  - Patient Care Planning/*standards
MH  - Pregnancy
MH  - Randomized Controlled Trials as Topic
PMC - PMC4238062
MID - EMS57065
OID - NLM: EMS57065
EDAT- 2012/09/14 06:00
MHDA- 2012/10/31 06:00
CRDT- 2012/09/14 06:00
PHST- 2012/09/14 06:00 [entrez]
PHST- 2012/09/14 06:00 [pubmed]
PHST- 2012/10/31 06:00 [medline]
AID - 10.1002/14651858.CD000352.pub2 [doi]
PST - epublish
SO  - Cochrane Database Syst Rev. 2012 Sep 12;(9):CD000352. doi:
      10.1002/14651858.CD000352.pub2.


PMID- 22971529
OWN - NLM
STAT- MEDLINE
DCOM- 20130201
LR  - 20161125
IS  - 1607-8454 (Electronic)
IS  - 1024-5332 (Linking)
VI  - 17
IP  - 5
DP  - 2012 Sep
TI  - Guidelines on obtaining consent for systemic anti-cancer therapy in adults.
PG  - 249-54
LID - 10.1179/1607845412Y.0000000022 [doi]
AB  - This guideline, initially drawn up for use in the UK, is essentially based on
      ethical principles and should be applicable across other jurisdictions. The
      document specifically addresses the issues which surround obtaining consent from 
      adults for the administration of systemic anti-cancer therapy in the
      haemato-oncology setting. Consenting to a treatment or procedure is a complex
      medical, ethical, and legal issue. The process of obtaining consent and the
      general steps that should be taken by the healthcare professional involved in
      obtaining consent from a patient are discussed, and the potential legal and
      ethical pitfalls which can be encountered are outlined. Of fundamental importance
      are the requirements that agreement must be given voluntarily, based on adequate 
      information, and the patient must have the ability to understand and retain the
      information given and be in a position to use it in order to reach a decision.
      The consenting process should include an explanation of the expected outcomes and
      possible side effects of treatment even if these are unlikely to occur, and the
      nature of the consenting process undertaken should be clearly documented.
      Obtaining consent in an emergency situation is also discussed, as is the process 
      of consenting in individuals with impaired capacity or special needs. Withdrawal 
      of consent and refusal of treatment are also considered.
FAU - Treleaven, J
AU  - Treleaven J
AD  - Royal Marsden Hospital, Surrey, UK. Jennifer.Treleaven@rmh.nhs.uk
FAU - Gadd, E
AU  - Gadd E
FAU - Cullis, J
AU  - Cullis J
FAU - Favre, J
AU  - Favre J
FAU - McLeod, A
AU  - McLeod A
FAU - Meller, S
AU  - Meller S
FAU - Milligan, D
AU  - Milligan D
FAU - Neilson, R
AU  - Neilson R
FAU - Quinn, B
AU  - Quinn B
FAU - Webb, A
AU  - Webb A
FAU - Wimperis, J
AU  - Wimperis J
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Hematology
JT  - Hematology (Amsterdam, Netherlands)
JID - 9708388
SB  - IM
MH  - Adult
MH  - *Decision Making
MH  - *Ethics, Medical
MH  - Female
MH  - Humans
MH  - *Informed Consent
MH  - Male
MH  - Neoplasms/*therapy
MH  - *Practice Guidelines as Topic
MH  - Treatment Refusal
MH  - United Kingdom
EDAT- 2012/09/14 06:00
MHDA- 2013/02/05 06:00
CRDT- 2012/09/14 06:00
PHST- 2012/09/14 06:00 [entrez]
PHST- 2012/09/14 06:00 [pubmed]
PHST- 2013/02/05 06:00 [medline]
AID - 10.1179/1607845412Y.0000000022 [doi]
PST - ppublish
SO  - Hematology. 2012 Sep;17(5):249-54. doi: 10.1179/1607845412Y.0000000022.


PMID- 22971454
OWN - NLM
STAT- MEDLINE
DCOM- 20140924
LR  - 20170926
IS  - 1701-2163 (Print)
IS  - 1701-2163 (Linking)
VI  - 34
IP  - 9
DP  - 2012 Sep
TI  - A national study of the provision of oncofertility services to female patients in
      Canada.
PG  - 849-858
LID - S1701-2163(16)35384-1 [pii]
LID - 10.1016/S1701-2163(16)35384-1 [doi]
AB  - OBJECTIVE: This study aimed to gain a better understanding of the fertility
      preservation services provided by Canadian fertility clinics to women with
      cancer. METHODS: We invited a total of 76 fertility clinics across Canada to
      complete a mailed questionnaire related to the availability, accessibility,
      affordability, and utilization of fertility preservation services for oncology
      patients. RESULTS: The total response rate was 59.2%: 72.4% for IVF clinics and
      51.1% for fertility centres without on-site IVF. Not all the responding IVF
      centres accepted oncology referrals for women. Six clinics without on-site IVF
      accepted cancer patients for consultation. The medical consultation fees are
      covered by public health insurance in all provinces. The majority of respondents 
      expedited the referrals to schedule an initial medical appointment within three
      days. Despite that, the referral volume reported by respondents was markedly low 
      for all except two facilities. With over 4000 young women of reproductive age
      given a diagnosis of cancer each year in Canada, the findings suggest that cancer
      patients are severely under-served by fertility clinics. CONCLUSION: There is a
      need to develop a stronger partnership between the fields of oncology and
      reproductive medicine to further improve access of patients with cancer to
      fertility preservation services. Development of evidence-based practice
      guidelines covering medical, clinical, psychosocial, ethical, and legal aspects
      geared to the Canadian health care system would help to avoid ambiguity relating 
      to the roles and responsibilities in the provision of fertility preservation
      services. Such processes would ensure optimization of services so that all young 
      cancer patients would receive the best care in protecting their fertility.
FAU - Yee, Samantha
AU  - Yee S
AD  - Centre for Fertility and Reproductive Health, Mount Sinai Hospital, Toronto ON;
      Factor-Inwentash Faculty of Social Work, University of Toronto, Toronto ON.
FAU - Buckett, William
AU  - Buckett W
AD  - McGill University Reproductive Centre, Royal Victoria Hospital, Montreal QC;
      Department of Obstetrics and Gynecology, McGill University, Montreal QC.
FAU - Campbell, Sharon
AU  - Campbell S
AD  - PROPEL Centre for Population Health Impact, Waterloo ON.
FAU - Yanofsky, Rochelle
AU  - Yanofsky R
AD  - CancerCare Manitoba, Winnipeg MB; Pediatric Hematology and Oncology, Department
      of Pediatrics and Child Health, University of Manitoba, Winnipeg MB.
FAU - Barr, Ronald D
AU  - Barr RD
AD  - Departments of Pediatrics, Pathology and Medicine, McMaster University, Hamilton 
      ON.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Obstet Gynaecol Can
JT  - Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et
      gynecologie du Canada : JOGC
JID - 101126664
SB  - IM
CIN - J Obstet Gynaecol Can. 2013 Jan;35(1):21. PMID: 23343792
MH  - Canada
MH  - Costs and Cost Analysis
MH  - Female
MH  - Fertility Preservation/economics/*statistics & numerical data
MH  - Fertilization in Vitro
MH  - Health Services Accessibility/statistics & numerical data
MH  - Humans
MH  - Neoplasms/*therapy
MH  - Surveys and Questionnaires
MH  - Vulnerable Populations/statistics & numerical data
EDAT- 2012/09/14 06:00
MHDA- 2014/09/25 06:00
CRDT- 2012/09/14 06:00
PHST- 2012/09/14 06:00 [entrez]
PHST- 2012/09/14 06:00 [pubmed]
PHST- 2014/09/25 06:00 [medline]
AID - S1701-2163(16)35384-1 [pii]
AID - 10.1016/S1701-2163(16)35384-1 [doi]
PST - ppublish
SO  - J Obstet Gynaecol Can. 2012 Sep;34(9):849-858. doi:
      10.1016/S1701-2163(16)35384-1.


PMID- 22971244
OWN - NLM
STAT- MEDLINE
DCOM- 20131028
LR  - 20211203
IS  - 1750-3639 (Electronic)
IS  - 1015-6305 (Linking)
VI  - 23
IP  - 3
DP  - 2013 May
TI  - Aurora kinase B is a potential therapeutic target in pediatric diffuse intrinsic 
      pontine glioma.
PG  - 244-53
LID - 10.1111/j.1750-3639.2012.00633.x [doi]
AB  - Pediatric high-grade astrocytomas (HGAs) account for 15-20% of all pediatric
      central nervous system tumors. These neoplasms predominantly involve the
      supratentorial hemispheres or the pons--diffuse intrinsic pontine gliomas (DIPG).
      Assumptions that pediatric HGAs are biologically similar to adult HGAs have
      recently been challenged, and the development of effective therapeutic modalities
      for DIPG and supratentorial HGA hinges on a better understanding of their
      biological properties. Here, 20 pediatric HGAs (9 DIPGs and 11 supratentorial
      HGAs) were subject to gene expression profiling following approval by the
      research ethics board at our institution. Many of these tumors showed expression 
      signatures composed of genes that promote G1/S and G2/M cell cycle progression.
      In particular, Aurora kinase B (AURKB) was consistently and highly overexpressed 
      in 6/9 DIPGs and 8/11 HGAs. Array data were validated using quantitative
      real-time PCR and immunohistochemistry, as well as cross-validation of our data
      set with previously published series. Inhibition of Aurora B activity in DIPG and
      in pediatric HGA cell lines resulted in growth arrest accompanied by
      morphological changes, cell cycle aberrations, nuclear fractionation and
      polyploidy as well as a reduction in colony formation. Our data highlight Aurora 
      B as a potential therapeutic target in DIPG.
CI  - (c) 2012 The Authors; Brain Pathology (c) 2012 International Society of
      Neuropathology.
FAU - Buczkowicz, Pawel
AU  - Buczkowicz P
AD  - Division of Pathology, The Hospital for Sick Children, Toronto, ON, Canada.
FAU - Zarghooni, Maryam
AU  - Zarghooni M
FAU - Bartels, Ute
AU  - Bartels U
FAU - Morrison, Andrew
AU  - Morrison A
FAU - Misuraca, Katherine L
AU  - Misuraca KL
FAU - Chan, Tiffany
AU  - Chan T
FAU - Bouffet, Eric
AU  - Bouffet E
FAU - Huang, Annie
AU  - Huang A
FAU - Becher, Oren
AU  - Becher O
FAU - Hawkins, Cynthia
AU  - Hawkins C
LA  - eng
GR  - MOP 115004/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121011
PL  - Switzerland
TA  - Brain Pathol
JT  - Brain pathology (Zurich, Switzerland)
JID - 9216781
RN  - 0 (Antineoplastic Agents)
RN  - EC 2.7.11.1 (AURKB protein, human)
RN  - EC 2.7.11.1 (Aurora Kinase B)
RN  - EC 2.7.11.1 (Aurora Kinases)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
SB  - IM
MH  - Antineoplastic Agents/*pharmacology/*therapeutic use
MH  - Aurora Kinase B
MH  - Aurora Kinases
MH  - Blotting, Western
MH  - Brain Stem Neoplasms/*drug therapy/*enzymology
MH  - Cell Cycle/drug effects
MH  - Cell Line, Tumor
MH  - Child
MH  - Fluorescent Antibody Technique
MH  - Glioma/*drug therapy/*enzymology
MH  - Humans
MH  - Immunohistochemistry
MH  - Protein Serine-Threonine Kinases/*drug effects
MH  - Real-Time Polymerase Chain Reaction
PMC - PMC8029082
EDAT- 2012/09/14 06:00
MHDA- 2013/10/29 06:00
CRDT- 2012/09/14 06:00
PHST- 2012/07/05 00:00 [received]
PHST- 2012/08/16 00:00 [accepted]
PHST- 2012/09/14 06:00 [entrez]
PHST- 2012/09/14 06:00 [pubmed]
PHST- 2013/10/29 06:00 [medline]
AID - 10.1111/j.1750-3639.2012.00633.x [doi]
PST - ppublish
SO  - Brain Pathol. 2013 May;23(3):244-53. doi: 10.1111/j.1750-3639.2012.00633.x. Epub 
      2012 Oct 11.


PMID- 22970797
OWN - NLM
STAT- MEDLINE
DCOM- 20130522
LR  - 20211021
IS  - 1472-6963 (Electronic)
IS  - 1472-6963 (Linking)
VI  - 12
DP  - 2012 Sep 12
TI  - Social and economic costs and health-related quality of life in stroke survivors 
      in the Canary Islands, Spain.
PG  - 315
LID - 10.1186/1472-6963-12-315 [doi]
AB  - BACKGROUND: Cost-of-illness analysis is the main method of providing an overall
      vision of the economic impact of a disease. Such studies have been used to set
      priorities for healthcare policies and inform resource allocation. The aim of
      this study was to determine the economic burden and health-related quality of
      life (HRQOL) in the first, second and third years after surviving a stroke in the
      Canary Islands, Spain. METHODS: Cross-sectional, retrospective study of 448
      patients with stroke based on ICD 9 discharge codes, who received outpatient care
      at five hospitals. The study was approved by the Research Ethics Committee of
      Nuestra Senora de la Candelaria University Hospital. Data on demographic
      characteristics, health resource utilization, informal care, labor productivity
      losses and HRQOL were collected from the hospital admissions databases and
      questionnaires completed by stroke patients or their caregivers. Labor
      productivity losses were calculated from physical units and converted into
      monetary units with a human capital-based method. HRQOL was measured with the
      EuroQol EQ-5D questionnaire. Healthcare costs, productivity losses and informal
      care costs were analyzed with log-normal, probit and ordered probit multivariate 
      models. RESULTS: The average cost for each stroke survivor was euro17 618 in the 
      first, euro14 453 in the second and euro12 924 in the third year after the
      stroke; the reference year for unit prices was 2004. The largest expenditures in 
      the first year were informal care and hospitalizations; in the second and third
      years the main costs were for informal care, productivity losses and medication. 
      Mean EQ-5D index scores for stroke survivors were 0.50 for the first, 0.47 for
      the second and 0.46 for the third year, and mean EQ-5D visual analog scale scores
      were 56, 52 and 55, respectively. CONCLUSIONS: The main strengths of this study
      lie in our bottom-up-approach to costing, and in the evaluation of stroke
      survivors from a broad perspective (societal costs) in the first, second and
      third years after surviving the stroke. This type of analysis is rare in the
      Spanish context. We conclude that stroke incurs considerable societal costs among
      survivors to three years and there is substantial deterioration in HRQOL.
FAU - Lopez-Bastida, Julio
AU  - Lopez-Bastida J
AD  - University Castilla-La Mancha, Talavera de la Reina, Toledo, Spain.
      julio.lopezbastida@uclm.es
FAU - Oliva Moreno, Juan
AU  - Oliva Moreno J
FAU - Worbes Cerezo, Melany
AU  - Worbes Cerezo M
FAU - Perestelo Perez, Lilisbeth
AU  - Perestelo Perez L
FAU - Serrano-Aguilar, Pedro
AU  - Serrano-Aguilar P
FAU - Monton-Alvarez, Fernando
AU  - Monton-Alvarez F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120912
PL  - England
TA  - BMC Health Serv Res
JT  - BMC health services research
JID - 101088677
SB  - IM
MH  - Aged
MH  - Caregivers/psychology/statistics & numerical data
MH  - *Cost of Illness
MH  - Cross-Sectional Studies
MH  - Female
MH  - Health Care Costs/statistics & numerical data
MH  - Health Expenditures
MH  - *Health Status Indicators
MH  - Humans
MH  - International Classification of Diseases
MH  - Male
MH  - Middle Aged
MH  - Pain Measurement
MH  - *Quality of Life
MH  - Retrospective Studies
MH  - Social Conditions
MH  - Spain
MH  - Stroke/*economics/physiopathology
MH  - Surveys and Questionnaires
MH  - Survivors/*psychology/statistics & numerical data
PMC - PMC3468368
EDAT- 2012/09/14 06:00
MHDA- 2013/05/23 06:00
CRDT- 2012/09/14 06:00
PHST- 2011/10/19 00:00 [received]
PHST- 2012/08/31 00:00 [accepted]
PHST- 2012/09/14 06:00 [entrez]
PHST- 2012/09/14 06:00 [pubmed]
PHST- 2013/05/23 06:00 [medline]
AID - 1472-6963-12-315 [pii]
AID - 10.1186/1472-6963-12-315 [doi]
PST - epublish
SO  - BMC Health Serv Res. 2012 Sep 12;12:315. doi: 10.1186/1472-6963-12-315.


PMID- 22970553
OWN - NLM
STAT- MEDLINE
DCOM- 20121001
LR  - 20120913
IS  - 0746-1739 (Print)
IS  - 0746-1739 (Linking)
VI  - 30
IP  - 4
DP  - 2012 Jul-Aug
TI  - Quality in life and death: can we have the conversations?
PG  - 224-6, 232
AB  - As nurses, we participate in providing social justice through the delivery of
      health care. While much of what we do supports healthier lifestyles and healing, 
      we must also acknowledge that for an increasing number of our patients, life may 
      have become irreversibly painful and unwanted. Nurses have acute sensitivity to
      the dilemmas faced by dying patients and their families. Our empathy and know-how
      in such cases dictates that we make an effort to relieve such suffering. Easing
      suffering will require assessments of the changing terrain of end-of-life care
      and the populations receiving that care. Dialogues can bridge the interest of
      patients, providers, and policymakers and ultimately legislation that reinforces 
      ethical end-of-life care and ensures a voice for those who will be most affected.
FAU - Gardner, Deborah B
AU  - Gardner DB
AD  - Hawaii State Center for Nursing, Honolulu, HI, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Nurs Econ
JT  - Nursing economic$
JID - 8404213
MH  - *Death
MH  - Health Policy
MH  - Humans
MH  - Nurses
MH  - Patient Advocacy
MH  - *Quality of Life
MH  - Terminal Care/economics/standards
EDAT- 2012/09/14 06:00
MHDA- 2012/10/02 06:00
CRDT- 2012/09/14 06:00
PHST- 2012/09/14 06:00 [entrez]
PHST- 2012/09/14 06:00 [pubmed]
PHST- 2012/10/02 06:00 [medline]
PST - ppublish
SO  - Nurs Econ. 2012 Jul-Aug;30(4):224-6, 232.


PMID- 22797745
OWN - NLM
STAT- MEDLINE
DCOM- 20120928
LR  - 20211021
IS  - 1944-7884 (Electronic)
IS  - 1525-4135 (Linking)
VI  - 60 Suppl 3
DP  - 2012 Aug 15
TI  - Voluntary medical male circumcision: an HIV prevention priority for PEPFAR.
PG  - S88-95
LID - 10.1097/QAI.0b013e31825cac4e [doi]
AB  - As the science demonstrating strong evidence for voluntary medical male
      circumcision (VMMC) for HIV prevention has evolved, the President's Emergency
      Plan for AIDS Relief (PEPFAR) has collaborated with international agencies,
      donors, and partner country governments supporting VMMC programming. Mathematical
      models forecast that quickly reaching a large number of uncircumcised men with
      VMMC in strategically chosen populations may dramatically reduce community-level 
      HIV incidence and save billions of dollars in HIV care and treatment costs.
      Because VMMC is a 1-time procedure that confers life-long partial protection
      against HIV, programs for adult men are vital short-term investments with
      long-term benefits. VMMC also provides a unique opportunity to reach boys and men
      with HIV testing and counseling services and referrals for other HIV services,
      including treatment. After formal recommendations by WHO in 2007, priority
      countries have pursued expansion of VMMC. More than 1 million males have received
      VMMC thus far, with the most notable successes coming from Kenya's Nyanza
      Province. However, a myriad of necessary cultural, political, and ethical
      considerations have moderated the pace of overall success. Because many millions 
      more uncircumcised men would benefit from VMMC services now, US President Barack 
      Obama committed PEPFAR to provide 4.7 million males with VMMC by 2014. Innovative
      circumcision methods-such as medical devices that remove the foreskin without
      injected anesthesia and/or sutures-are being rigorously evaluated. Incorporation 
      of safe innovations into surgical VMMC programs may provide the opportunity to
      reach more men more quickly with services and dramatically reduce HIV incidence
      for all.
FAU - Reed, Jason Bailey
AU  - Reed JB
AD  - US Centers for Disease Control and Prevention, Atlanta, GA, USA. jreed1@cdc.gov
FAU - Njeuhmeli, Emmanuel
AU  - Njeuhmeli E
FAU - Thomas, Anne Goldzier
AU  - Thomas AG
FAU - Bacon, Melanie C
AU  - Bacon MC
FAU - Bailey, Robert
AU  - Bailey R
FAU - Cherutich, Peter
AU  - Cherutich P
FAU - Curran, Kelly
AU  - Curran K
FAU - Dickson, Kim
AU  - Dickson K
FAU - Farley, Tim
AU  - Farley T
FAU - Hankins, Catherine
AU  - Hankins C
FAU - Hatzold, Karin
AU  - Hatzold K
FAU - Justman, Jessica
AU  - Justman J
FAU - Mwandi, Zebedee
AU  - Mwandi Z
FAU - Nkinsi, Luke
AU  - Nkinsi L
FAU - Ridzon, Renee
AU  - Ridzon R
FAU - Ryan, Caroline
AU  - Ryan C
FAU - Bock, Naomi
AU  - Bock N
LA  - eng
GR  - P30 AI082151/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Acquir Immune Defic Syndr
JT  - Journal of acquired immune deficiency syndromes (1999)
JID - 100892005
SB  - IM
MH  - Circumcision, Male/*trends
MH  - Communicable Disease Control/*methods/organization & administration/trends
MH  - Disease Transmission, Infectious/*prevention & control
MH  - Global Health
MH  - HIV Infections/epidemiology/*prevention & control/*transmission
MH  - Humans
MH  - International Cooperation
MH  - Male
MH  - National Health Programs/organization & administration/trends
MH  - Public-Private Sector Partnerships/organization & administration/trends
MH  - United States
PMC - PMC3663585
MID - NIHMS468488
EDAT- 2012/09/14 06:00
MHDA- 2012/09/29 06:00
CRDT- 2012/07/17 06:00
PHST- 2012/07/17 06:00 [entrez]
PHST- 2012/09/14 06:00 [pubmed]
PHST- 2012/09/29 06:00 [medline]
AID - 10.1097/QAI.0b013e31825cac4e [doi]
AID - 00126334-201208153-00007 [pii]
PST - ppublish
SO  - J Acquir Immune Defic Syndr. 2012 Aug 15;60 Suppl 3:S88-95. doi:
      10.1097/QAI.0b013e31825cac4e.


PMID- 22970444
OWN - NLM
STAT- MEDLINE
DCOM- 20121210
LR  - 20161018
IS  - 1997-7298 (Print)
IS  - 1997-7298 (Linking)
VI  - 112
IP  - 5
DP  - 2012
TI  - [Ethical and legal responsibility fr diagnosis of the dementia syndrome].
PG  - 114-7
FAU - Nosachev, G N
AU  - Nosachev GN
LA  - rus
PT  - Journal Article
PL  - Russia (Federation)
TA  - Zh Nevrol Psikhiatr Im S S Korsakova
JT  - Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
JID - 9712194
SB  - IM
MH  - Dementia/*diagnosis
MH  - *Ethics, Medical
MH  - Humans
MH  - *Liability, Legal
MH  - Russia
MH  - Syndrome
EDAT- 2012/09/13 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/09/13 06:00
PHST- 2012/09/13 06:00 [entrez]
PHST- 2012/09/13 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
PST - ppublish
SO  - Zh Nevrol Psikhiatr Im S S Korsakova. 2012;112(5):114-7.


PMID- 22969199
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20220409
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Linking)
VI  - 18
IP  - 32
DP  - 2012 Aug 28
TI  - Predictive value of symptoms and demographics in diagnosing malignancy or peptic 
      stricture.
PG  - 4357-62
LID - 10.3748/wjg.v18.i32.4357 [doi]
AB  - AIM: To determine which features of history and demographics predict a diagnosis 
      of malignancy or peptic stricture in patients presenting with dysphagia. METHODS:
      A prospective case-control study of 2000 consecutive referrals (1031 female, age 
      range: 17-103 years) to a rapid access service for dysphagia, based in a teaching
      hospital within the United Kingdom, over 7 years. The service consists of a
      nurse-led telephone triage followed by investigation (barium swallow or
      gastroscopy), if appropriate, within 2 wk. Logistic regression analysis of
      demographic and clinical variables was performed. This includes age, sex,
      duration of dysphagia, whether to liquids or solids, and whether there are
      associated features (reflux, odynophagia, weight loss, regurgitation). We
      determined odds ratio (OR) for these variables for the diagnoses of malignancy
      and peptic stricture. We determined the value of the Edinburgh Dysphagia Score
      (EDS) in predicting cancer in our cohort. Multivariate logistic regression was
      performed and P < 0.05 considered significant. The local ethics committee
      confirmed ethics approval was not required (audit). RESULTS: The commonest
      diagnosis is gastro-esophageal reflux disease (41.3%). Malignancy (11.0%) and
      peptic stricture (10.0%) were also relatively common. Malignancies were diagnosed
      by histology (97%) or on radiological criteria, either sequential barium swallows
      showing progression of disease or unequivocal evidence of malignancy on computed 
      tomography. The majority of malignancies were esophago-gastric in origin but ear,
      nose and throat tumors, pancreatic cancer and extrinsic compression from lung or 
      mediastinal metastatic cancer were also found. Malignancy was statistically more 
      frequent in older patients (aged >73 years, OR 1.1-3.3, age < 60 years 6.5%,
      60-73 years 11.2%, > 73 years 11.8%, P < 0.05), males (OR 2.2-4.8, males 14.5%,
      females 5.6%, P < 0.0005), short duration of dysphagia (</= 8 wk, OR 4.5-20.7,
      16.6%, 8-26 wk 14.5%, > 26 wk 2.5%, P < 0.0005), progressive symptoms (OR
      1.3-2.6: progressive 14.8%, intermittent 9.3%, P < 0.001), with weight loss of
      >/= 2 kg (OR 2.5-5.1, weight loss 22.1%, without weight loss 6.4%, P < 0.0005)
      and without reflux (OR 1.2-2.5, reflux 7.2%, no reflux 15.5%, P < 0.0005). The
      likelihood of malignancy was greater in those who described true dysphagia (food 
      or drink sticking within 5 s of swallowing than those who did not (15.1% vs 5.2% 
      respectively, P < 0.001). The sensitivity, specificity, positive predictive value
      and negative predictive value of the EDS were 98.4%, 9.3%, 11.8% and 98.0%
      respectively. Three patients with an EDS of 3 (high risk EDS >/= 3.5) had
      malignancy. Unlike the original validation cohort, there was no difference in
      likelihood of malignancy based on level of dysphagia (pharyngeal level dysphagia 
      11.9% vs mid sternal or lower sternal dysphagia 12.4%). Peptic stricture was
      statistically more frequent in those with longer duration of symptoms (> 6 mo, OR
      1.2-2.9, </= 8 wk 9.8%, 8-26 wk 10.6%, > 26 wk 15.7%, P < 0.05) and over 60 s (OR
      1.2-3.0, age < 60 years 6.2%, 60-73 years 10.2%, > 73 years 10.6%, P < 0.05).
      CONCLUSION: Malignancy and peptic stricture are frequent findings in those
      referred with dysphagia. The predictive value for associated features could help 
      determine need for fast track investigation whilst reducing service pressures.
FAU - Murray, Iain A
AU  - Murray IA
AD  - Department of Gastroenterology, Royal Cornwall Hospital, Truro, Cornwall TR1 3LJ,
      United Kingdom. iain.murray@rcht.cornwall.nhs.uk
FAU - Palmer, Joanne
AU  - Palmer J
FAU - Waters, Carolyn
AU  - Waters C
FAU - Dalton, Harry R
AU  - Dalton HR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
RN  - 25BB7EKE2E (Barium Sulfate)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Barium Sulfate
MH  - Case-Control Studies
MH  - Comorbidity
MH  - Deglutition Disorders/*diagnosis/epidemiology
MH  - Esophageal Neoplasms/*diagnosis/epidemiology
MH  - Esophageal Stenosis/*diagnosis/epidemiology
MH  - Female
MH  - Gastroesophageal Reflux/epidemiology
MH  - Gastroscopy
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - *Severity of Illness Index
MH  - Weight Loss
MH  - Young Adult
PMC - PMC3436051
OTO - NOTNLM
OT  - Barium swallow
OT  - Deglutition disorders
OT  - Dysphagia
OT  - Esophageal neoplasms
OT  - Esophageal stenosis
OT  - Gastroscopy
OT  - Predictive value of tests
EDAT- 2012/09/13 06:00
MHDA- 2013/03/13 06:00
CRDT- 2012/09/13 06:00
PHST- 2012/06/01 00:00 [received]
PHST- 2012/07/23 00:00 [revised]
PHST- 2012/07/28 00:00 [accepted]
PHST- 2012/09/13 06:00 [entrez]
PHST- 2012/09/13 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
AID - 10.3748/wjg.v18.i32.4357 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2012 Aug 28;18(32):4357-62. doi: 10.3748/wjg.v18.i32.4357.


PMID- 22968835
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130318
LR  - 20211021
IS  - 0920-9069 (Print)
IS  - 0920-9069 (Linking)
VI  - 65
IP  - 3
DP  - 2013 May
TI  - Stem cells for reprogramming: could hUMSCs be a better choice?
PG  - 335-45
LID - 10.1007/s10616-012-9489-3 [doi]
AB  - Human umbilical cord mesenchymal stem cells (hUMSC) are primitive multipotent
      cells capable of differentiating into cells of different lineages. They can be an
      alternative source of pluripotent cells since they are ethically and regulatory
      approved, are easily obtained and have low immunogenicity compared to embryonic
      stem cells which are dogged with numerous controversies. hUMSC can be a great
      source for cell and transplantation therapy.
FAU - Duya, Paulina
AU  - Duya P
AD  - Tianjin University of Traditional Chinese Medicine, 312 Anshan West Road, Nankai 
      district, Tianjin, China.
FAU - Bian, Yuhong
AU  - Bian Y
FAU - Chu, Xiaoqian
AU  - Chu X
FAU - Zhang, Yanjun
AU  - Zhang Y
LA  - eng
PT  - Journal Article
DEP - 20120912
PL  - United States
TA  - Cytotechnology
JT  - Cytotechnology
JID - 8807027
PMC - PMC3597174
EDAT- 2012/09/13 06:00
MHDA- 2012/09/13 06:01
CRDT- 2012/09/13 06:00
PHST- 2011/12/28 00:00 [received]
PHST- 2012/07/23 00:00 [accepted]
PHST- 2012/09/13 06:00 [entrez]
PHST- 2012/09/13 06:00 [pubmed]
PHST- 2012/09/13 06:01 [medline]
AID - 10.1007/s10616-012-9489-3 [doi]
PST - ppublish
SO  - Cytotechnology. 2013 May;65(3):335-45. doi: 10.1007/s10616-012-9489-3. Epub 2012 
      Sep 12.


PMID- 22968494
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121212
LR  - 20211021
IS  - 1092-8480 (Print)
IS  - 1092-8480 (Linking)
VI  - 14
IP  - 6
DP  - 2012 Dec
TI  - Updates on treatment of attention-deficit/hyperactivity disorder: facts,
      comments, and ethical considerations.
PG  - 594-607
LID - 10.1007/s11940-012-0197-2 [doi]
AB  - OPINION STATEMENT: Within the last 2 years the bulk of information on evidence
      based treatments in ADHD was reviewed quite intensively and new empirical studies
      could be added. This update reports comprehensively about actual and essential
      facts in the field related to brain development and sensitive periods, predictors
      of treatment, safety of medication, value of naturalistic studies, new drugs and 
      complementary medicine, behavioral interventions including neurofeedback and
      psychosocial treatment, treatment of comorbidity, and ethical considerations
      including preventive aspects. The updated combination of well selected evidence
      based treatments (ie, pharma plus non-pharma) seems to be clinically and
      ethically recommended as also suggested by the European and American guidelines
      on ADHD.
FAU - Rothenberger, Aribert
AU  - Rothenberger A
AD  - Child and Adolescent Psychiatry, University Medicine Gottingen, von-Siebold-Str. 
      5, 37075, Gottingen, Germany, arothen@gwdg.de.
FAU - Rothenberger, Lillian Geza
AU  - Rothenberger LG
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Curr Treat Options Neurol
JT  - Current treatment options in neurology
JID - 9815940
PMC - PMC3501189
EDAT- 2012/09/13 06:00
MHDA- 2012/09/13 06:01
CRDT- 2012/09/13 06:00
PHST- 2012/09/13 06:00 [entrez]
PHST- 2012/09/13 06:00 [pubmed]
PHST- 2012/09/13 06:01 [medline]
AID - 10.1007/s11940-012-0197-2 [doi]
PST - ppublish
SO  - Curr Treat Options Neurol. 2012 Dec;14(6):594-607. doi:
      10.1007/s11940-012-0197-2.


PMID- 22968329
OWN - NLM
STAT- MEDLINE
DCOM- 20130211
LR  - 20211021
IS  - 1612-9210 (Electronic)
IS  - 1612-9202 (Linking)
VI  - 9
IP  - 3
DP  - 2012 Sep
TI  - Aldo Leopold's land health from a resilience point of view: self-renewal capacity
      of social-ecological systems.
PG  - 278-87
LID - 10.1007/s10393-012-0796-0 [doi]
AB  - Health approaches to ecology have a strong basis in Aldo Leopold's thinking, and 
      contemporary ecohealth in turn has a strong philosophical basis in Leopold. To
      commemorate the 125th anniversary of Leopold's birth (1887-1948), we revisit his 
      ideas, specifically the notions of stewardship (land ethic), productive use of
      ecosystems (land), and ecosystem renewal. We focus on Leopold's perspective on
      the self-renewal capacity of the land, as understood in terms of integrity and
      land health, from the contemporary perspective of resilience theory and
      ecological theory more generally. Using a broad range of literature, we explore
      insights and implications of Leopold's work for today's human-environment
      relationships (integrated social-ecological systems), concerns for biodiversity, 
      the development of agency with respect to stewardship, and key challenges of his 
      time and of ours. Leopold's seminal concept of land health can be seen as a
      triangulation of productive use, self-renewal, and stewardship, and it can be
      reinterpreted through the resilience lens as the health of social-ecological
      systems. In contemporary language, this involves the maintenance of biodiversity 
      and ecosystem services, and the ability to exercise agency both for conservation 
      and for environmental justice.
FAU - Berkes, Fikret
AU  - Berkes F
AD  - Natural Resources Institute, University of Manitoba, Winnipeg, MB, Canada.
      berkes@cc.umanitoba.ca
FAU - Doubleday, Nancy C
AU  - Doubleday NC
FAU - Cumming, Graeme S
AU  - Cumming GS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120912
PL  - United States
TA  - Ecohealth
JT  - EcoHealth
JID - 101222144
SB  - IM
MH  - Animals
MH  - Biodiversity
MH  - Economic Development
MH  - *Ecosystem
MH  - Environmental Health/*ethics
MH  - Humans
EDAT- 2012/09/13 06:00
MHDA- 2013/02/12 06:00
CRDT- 2012/09/13 06:00
PHST- 2012/03/13 00:00 [received]
PHST- 2012/07/13 00:00 [accepted]
PHST- 2012/07/04 00:00 [revised]
PHST- 2012/09/13 06:00 [entrez]
PHST- 2012/09/13 06:00 [pubmed]
PHST- 2013/02/12 06:00 [medline]
AID - 10.1007/s10393-012-0796-0 [doi]
PST - ppublish
SO  - Ecohealth. 2012 Sep;9(3):278-87. doi: 10.1007/s10393-012-0796-0. Epub 2012 Sep
      12.


PMID- 22967956
OWN - NLM
STAT- MEDLINE
DCOM- 20130317
LR  - 20211021
IS  - 2045-7960 (Print)
IS  - 2045-7960 (Linking)
VI  - 21
IP  - 4
DP  - 2012 Dec
TI  - Predicting first episode psychosis in those at high risk for genetic or cognitive
      reasons.
PG  - 323-8
LID - 10.1017/S2045796012000509 [doi]
AB  - Structural and functional magnetic resonance imaging (MRI) of patients with
      psychosis has advanced to the point where there are clear abnormalities at a
      group level between patients and groups of healthy controls, and suggestions of
      different patterns of abnormalities between groups of patients. A major area of
      research endeavour is being able to translate these group differences into
      clinically relevant predictions at an individual patient level. Here, we briefly 
      summarize our main findings in cohorts at high risk of psychosis because they
      come from families in which several members have schizophrenia or bipolar
      disorder, or have educational impairments. We highlight consistent predictors of 
      psychosis in those at high risk of schizophrenia for genetic or cognitive
      reasons, as compared with quite distinct profiles between those at genetic high
      risk of schizophrenia v. bipolar disorder on functional MRI during an executive
      language task. We also consider future research directions and ethical issues in 
      the early diagnostic testing of people at high risk of psychosis.
FAU - Lawrie, Stephen M
AU  - Lawrie SM
FAU - Stanfield, Andrew
AU  - Stanfield A
FAU - Johnstone, Eve C
AU  - Johnstone EC
FAU - McIntosh, Andrew M
AU  - McIntosh AM
LA  - eng
GR  - G0100102/Medical Research Council/United Kingdom
GR  - G9226254/Medical Research Council/United Kingdom
GR  - G9825423/Medical Research Council/United Kingdom
PT  - Editorial
PT  - Research Support, Non-U.S. Gov't
DEP - 20120912
PL  - England
TA  - Epidemiol Psychiatr Sci
JT  - Epidemiology and psychiatric sciences
JID - 101561091
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Bipolar Disorder/*diagnosis/genetics/physiopathology
MH  - Brain/pathology/*physiopathology
MH  - Cognition Disorders/pathology/physiopathology
MH  - Cohort Studies
MH  - Early Diagnosis
MH  - Functional Neuroimaging
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Longitudinal Studies
MH  - Magnetic Resonance Imaging
MH  - Prospective Studies
MH  - Psychotic Disorders/*diagnosis/genetics/physiopathology
MH  - Risk Factors
MH  - Schizophrenia/*diagnosis/genetics/physiopathology
PMC - PMC6998226
EDAT- 2012/09/13 06:00
MHDA- 2013/03/19 06:00
CRDT- 2012/09/13 06:00
PHST- 2012/09/13 06:00 [entrez]
PHST- 2012/09/13 06:00 [pubmed]
PHST- 2013/03/19 06:00 [medline]
AID - S2045796012000509 [pii]
AID - 10.1017/S2045796012000509 [doi]
PST - ppublish
SO  - Epidemiol Psychiatr Sci. 2012 Dec;21(4):323-8. doi: 10.1017/S2045796012000509.
      Epub 2012 Sep 12.


PMID- 22967300
OWN - NLM
STAT- MEDLINE
DCOM- 20130110
LR  - 20220310
IS  - 1365-2834 (Electronic)
IS  - 0966-0429 (Linking)
VI  - 20
IP  - 6
DP  - 2012 Sep
TI  - Clinical nurses' research capacity in a Norwegian university hospital: part 2.
PG  - 824-32
LID - 10.1111/j.1365-2834.2012.01473.x [doi]
AB  - AIM: To examine clinical nurses' research capacity and investigate related
      factors (i.e. the different phases of the research process). BACKGROUND: Research
      capacity includes research-related activities, being informed and applying
      research. METHODS: A descriptive-correlational design was used and data were
      collected by means of a structured questionnaire (59-items). A total of 364
      registered nurses from a University Hospital participated. The response rate was 
      61%. A majority reported that their research capacity was acceptable or weak
      (77.7%), while 7.6% who were involved in research rated it good or excellent;
      19.6% evaluated their level of research competence as fairly good and 4.1% wanted
      to increase their research involvement. RESULTS: The result demonstrated high
      statistical correlation, indicating that nurses are aware of the areas involved
      in research-related activities. Areas of perceived low competence were associated
      with reliability, sensitivity and specificity, control of confounding variables, 
      sources of funding and computerised statistical packages. Areas of capacity
      reported were access to literature, data collection, such as interviews and field
      notes, as well as research ethics. CONCLUSION: Enhanced research supervision is
      central for improving registered nurses' research capacity. IMPLICATIONS FOR
      NURSING MANAGEMENT: The findings from this survey should be useful for
      professional development.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Akerjordet, Kristin
AU  - Akerjordet K
AD  - Department of Health Studies, Faculty of Social Sciences, University of
      Stavanger, Stavanger, Norway.
FAU - Lode, Kirsten
AU  - Lode K
FAU - Severinsson, Elisabeth
AU  - Severinsson E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Nurs Manag
JT  - Journal of nursing management
JID - 9306050
MH  - *Attitude of Health Personnel
MH  - *Capacity Building
MH  - Clinical Nursing Research/*organization & administration
MH  - Female
MH  - Hospitals, University
MH  - Humans
MH  - Male
MH  - Norway
MH  - Nursing Evaluation Research
MH  - Nursing Staff, Hospital/*psychology
EDAT- 2012/09/13 06:00
MHDA- 2013/01/11 06:00
CRDT- 2012/09/13 06:00
PHST- 2012/09/13 06:00 [entrez]
PHST- 2012/09/13 06:00 [pubmed]
PHST- 2013/01/11 06:00 [medline]
AID - 10.1111/j.1365-2834.2012.01473.x [doi]
PST - ppublish
SO  - J Nurs Manag. 2012 Sep;20(6):824-32. doi: 10.1111/j.1365-2834.2012.01473.x.


PMID- 22967297
OWN - NLM
STAT- MEDLINE
DCOM- 20130110
LR  - 20120912
IS  - 1365-2834 (Electronic)
IS  - 0966-0429 (Linking)
VI  - 20
IP  - 6
DP  - 2012 Sep
TI  - Patient safety culture in home care: experiences of home-care nurses.
PG  - 794-801
LID - 10.1111/j.1365-2834.2012.01461.x [doi]
AB  - AIM: To explore home-care nurses' experiences of patient safety in their delivery
      of home care to older clients. BACKGROUND: High-risk organisations, such as the
      airline industry and the petroleum industry, have long been preoccupied with
      safety. Only recently has this also become a central theme in health care.
      METHOD: Four focus group interviews with 20 nurses who work in home care. A
      qualitative thematic analysis was performed. RESULTS: One main theme was
      identified: struggling with responsibility in different situations. It comprises 
      five subthemes: poor work morale and work ethic; documentation; lack of
      functional leadership; competence; and lack of updated routines and guidelines.
      CONCLUSIONS: Patient safety culture is compromised by a lack of leadership, lack 
      of responsibility among leadership, lack of routines, failure to update
      procedures, and a lack of knowledge and education among health-care workers.
      IMPLICATIONS FOR NURSING MANAGEMENT: Nurse managers need to be made more aware of
      the dilemmas faced by nurses, how they struggle with their responsibilities, how 
      they experience powerlessness in certain situations, and the lack of support they
      receive in decision-making.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Berland, Astrid
AU  - Berland A
AD  - Department of Health Education, Stord/Haugesund University College, Haugesund,
      Norway. astrid.berland@hsh.no
FAU - Holm, Anne Lise
AU  - Holm AL
FAU - Gundersen, Doris
AU  - Gundersen D
FAU - Bentsen, Signe Berit
AU  - Bentsen SB
LA  - eng
PT  - Journal Article
DEP - 20120816
PL  - England
TA  - J Nurs Manag
JT  - Journal of nursing management
JID - 9306050
MH  - Adult
MH  - Aged
MH  - *Attitude of Health Personnel
MH  - Female
MH  - Focus Groups
MH  - *Geriatric Nursing
MH  - Home Care Services/*organization & administration
MH  - Humans
MH  - Middle Aged
MH  - Nursing Methodology Research
MH  - Organizational Culture
MH  - *Patient Safety
MH  - Qualitative Research
MH  - Safety Management/*organization & administration
MH  - Young Adult
EDAT- 2012/09/13 06:00
MHDA- 2013/01/11 06:00
CRDT- 2012/09/13 06:00
PHST- 2012/06/15 00:00 [accepted]
PHST- 2012/09/13 06:00 [entrez]
PHST- 2012/09/13 06:00 [pubmed]
PHST- 2013/01/11 06:00 [medline]
AID - 10.1111/j.1365-2834.2012.01461.x [doi]
PST - ppublish
SO  - J Nurs Manag. 2012 Sep;20(6):794-801. doi: 10.1111/j.1365-2834.2012.01461.x. Epub
      2012 Aug 16.


PMID- 22967295
OWN - NLM
STAT- MEDLINE
DCOM- 20130110
LR  - 20120912
IS  - 1365-2834 (Electronic)
IS  - 0966-0429 (Linking)
VI  - 20
IP  - 6
DP  - 2012 Sep
TI  - Nursing students' perspectives on the patient and the impact of the nursing
      culture: a meta-synthesis.
PG  - 771-81
LID - 10.1111/j.1365-2834.2012.01470.x [doi]
AB  - AIM: To explore and interpret how nursing students develop their understanding of
      the patient as a human being. BACKGROUND: Understanding the patient is the main
      characteristic of good, caring performance. In addition, nurse leaders play an
      active role in creating a culture in which nursing students can flourish and
      improve. METHOD: This meta-synthesis was based on Noblit and Hare's
      meta-ethnography. RESULTS: The overarching metaphor was interpreted as the
      nursing students' capacity for compassion. Two central metaphors were revealed,
      based on how nursing students developed their understanding of the patient as a
      human being. These central metaphors were labelled 'The open door', comprising
      seven key metaphors and 'The closed door' based on two key metaphors. CONCLUSION:
      During practical training, the students observed both virtuous and unkind nurses.
      Virtue is a skill that can be taught, but not all students were able to learn it.
      Some students acquired the ability to reflect on ethical issues, while others did
      not. Therefore, good role models are of major importance. IMPLICATION FOR NURSING
      MANAGEMENT: The nurse leader should function as a facilitator in the students'
      efforts to gain the capacity to face the suffering patient and to develop an
      understanding of the patient's situation.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Rudolfsson, Gudrun
AU  - Rudolfsson G
AD  - Department of Nursing, Health and Culture, University West, Trollhattan, Sweden. 
      gudrun.rudolfsson@hv.se
FAU - Berggren, Ingela
AU  - Berggren I
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20120828
PL  - England
TA  - J Nurs Manag
JT  - Journal of nursing management
JID - 9306050
MH  - Adolescent
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - *Empathy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Nurse-Patient Relations
MH  - Nursing Care/*organization & administration
MH  - Nursing Education Research
MH  - Nursing Evaluation Research
MH  - Nursing Methodology Research
MH  - Organizational Culture
MH  - Qualitative Research
MH  - Students, Nursing/*psychology
MH  - Young Adult
EDAT- 2012/09/13 06:00
MHDA- 2013/01/11 06:00
CRDT- 2012/09/13 06:00
PHST- 2012/06/21 00:00 [accepted]
PHST- 2012/09/13 06:00 [entrez]
PHST- 2012/09/13 06:00 [pubmed]
PHST- 2013/01/11 06:00 [medline]
AID - 10.1111/j.1365-2834.2012.01470.x [doi]
PST - ppublish
SO  - J Nurs Manag. 2012 Sep;20(6):771-81. doi: 10.1111/j.1365-2834.2012.01470.x. Epub 
      2012 Aug 28.


PMID- 22967137
OWN - NLM
STAT- MEDLINE
DCOM- 20130913
LR  - 20161125
IS  - 1365-2931 (Electronic)
IS  - 1364-5706 (Linking)
VI  - 22
IP  - 2
DP  - 2013 Apr
TI  - 320-detector-row computed tomography arteriography using CO2 gas to detect
      malignant liver tumors.
PG  - 89-96
LID - 10.3109/13645706.2012.704876 [doi]
AB  - PURPOSE: We present the initial steps for 320-detector-row computed tomography
      arteriography using CO2 gas (320-MDCT CO2 arteriography) to detect the vascular
      area of malignant liver tumors. MATERIAL AND METHODS: This study was approved by 
      the Ethics Committee of our institution. Written prior informed consent was
      obtained from all patients. We studied six patients with primary and metastatic
      liver tumors (n = 26) and allergic reactions to iodinated contrast media or a
      tendency for renal failure. CO2 was injected at 1 ml/sec (volume 8 ml) into the
      common hepatic artery and a CT scan was acquired 12 seconds after the start of
      injection. The detection of the vascular area of the tumor or of intratumor air
      was evaluated with respect to the relationship between the size and location of
      the tumors. Cramer's V statistic was performed to explore the relationship (p <
      0.05). RESULTS: The vascular area was detected in 17 of the 26 tumors (65.4%).
      There was a correlation between the detection of the adjacent vascular area on
      CTA images acquired with the use of CO2 and the tumor site observed on
      previously-acquired MRI or CT images. CONCLUSION: 320-MDCT CO2 arteriography with
      microcatheters may be useful for the detection of the vascular area.
FAU - Sonoda, Akinaga
AU  - Sonoda A
AD  - Department of Radiology, Shiga University of Medical Science, Otsu, Shiga, Japan.
      akinagasonoda@yahoo.co.jp
FAU - Nitta, Norihisa
AU  - Nitta N
FAU - Ushio, Noritoshi
AU  - Ushio N
FAU - Nitta-Seko, Ayumi
AU  - Nitta-Seko A
FAU - Tomozawa, Yuki
AU  - Tomozawa Y
FAU - Watanabe, Shoubu
AU  - Watanabe S
FAU - Ohta, Shinichi
AU  - Ohta S
FAU - Takahashi, Masashi
AU  - Takahashi M
FAU - Murata, Kiyoshi
AU  - Murata K
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20120912
PL  - England
TA  - Minim Invasive Ther Allied Technol
JT  - Minimally invasive therapy & allied technologies : MITAT : official journal of
      the Society for Minimally Invasive Therapy
JID - 9612996
RN  - 142M471B3J (Carbon Dioxide)
SB  - IM
MH  - Angiography/*methods
MH  - Carbon Dioxide
MH  - Hepatic Artery
MH  - Humans
MH  - Liver Neoplasms/*diagnostic imaging/pathology/secondary
MH  - Magnetic Resonance Imaging
MH  - Multidetector Computed Tomography/*methods
MH  - Tomography, X-Ray Computed
EDAT- 2012/09/13 06:00
MHDA- 2013/09/14 06:00
CRDT- 2012/09/13 06:00
PHST- 2012/09/13 06:00 [entrez]
PHST- 2012/09/13 06:00 [pubmed]
PHST- 2013/09/14 06:00 [medline]
AID - 10.3109/13645706.2012.704876 [doi]
PST - ppublish
SO  - Minim Invasive Ther Allied Technol. 2013 Apr;22(2):89-96. doi:
      10.3109/13645706.2012.704876. Epub 2012 Sep 12.


PMID- 22966894
OWN - NLM
STAT- MEDLINE
DCOM- 20130129
LR  - 20211021
IS  - 1471-2261 (Electronic)
IS  - 1471-2261 (Linking)
VI  - 12
DP  - 2012 Sep 11
TI  - Implementation of shared decision making by physician training to optimise
      hypertension treatment. Study protocol of a cluster-RCT.
PG  - 73
LID - 10.1186/1471-2261-12-73 [doi]
AB  - BACKGROUND: Hypertension is one of the key factors causing cardiovascular
      diseases which make up the most frequent cause of death in industrialised
      nations. However about 60% of hypertensive patients in Germany treated with
      antihypertensives do not reach the recommended target blood pressure. The
      involvement of patients in medical decision making fulfils not only an ethical
      imperative but, furthermore, has the potential of higher treatment success. One
      concept to enhance the active role of patients is shared decision making. Until
      now there exists little information on the effects of shared decision making
      trainings for general practitioners on patient participation and on lowering
      blood pressure in hypertensive patients. METHODS/DESIGN: In a cluster-randomised 
      controlled trial 1800 patients receiving antihypertensives will be screened with 
      24 h ambulatory blood pressure monitoring in their general practitioners'
      practices. Only patients who have not reached their blood pressure target
      (approximately 1200) will remain in the study (T1 - T3). General practitioners of
      the intervention group will take part in a shared decision making-training after 
      baseline assessment (T0). General practitioners of the control group will treat
      their patients as usual. Primary endpoints are change of systolic blood pressure 
      and change of patients' perceived participation. Secondary endpoints are changes 
      of diastolic blood pressure, knowledge, medical adherence and cardiovascular
      risk. Data analysis will be performed with mixed effects models. DISCUSSION: The 
      hypothesis underlying this study is that shared decision making, realised by a
      shared decision making training for general practitioners, activates patients,
      facilitates patients' empowerment and contributes to a better hypertension
      control. This study is the first one that tests this hypothesis with a (cluster-)
      randomised trial and a large sample size.
FAU - Tinsel, Iris
AU  - Tinsel I
AD  - Department of Medicine, Division of General Practice, University Medical Centre
      Freiburg, Elsasserstr, 2 m, Freiburg, 79110, Germany.
      iris.tinsel@uniklinik-freiburg.de
FAU - Buchholz, Anika
AU  - Buchholz A
FAU - Vach, Werner
AU  - Vach W
FAU - Siegel, Achim
AU  - Siegel A
FAU - Durk, Thorsten
AU  - Durk T
FAU - Loh, Andreas
AU  - Loh A
FAU - Buchholz, Angela
AU  - Buchholz A
FAU - Niebling, Wilhelm
AU  - Niebling W
FAU - Fischer, Karl-Georg
AU  - Fischer KG
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20120911
PL  - England
TA  - BMC Cardiovasc Disord
JT  - BMC cardiovascular disorders
JID - 100968539
RN  - 0 (Antihypertensive Agents)
SB  - IM
MH  - Antihypertensive Agents/*therapeutic use
MH  - Attitude of Health Personnel
MH  - Blood Pressure/*drug effects
MH  - Blood Pressure Monitoring, Ambulatory
MH  - Cardiovascular Diseases/etiology/physiopathology/*prevention & control
MH  - *Choice Behavior
MH  - Communication
MH  - General Practice
MH  - General Practitioners/*education/psychology
MH  - Germany
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Hypertension/complications/diagnosis/*drug therapy/physiopathology
MH  - Medication Adherence
MH  - Patient Education as Topic
MH  - *Patient Participation
MH  - *Physician-Patient Relations
MH  - *Research Design
MH  - Risk Assessment
MH  - Risk Factors
MH  - Treatment Outcome
PMC - PMC3467178
EDAT- 2012/09/13 06:00
MHDA- 2013/01/30 06:00
CRDT- 2012/09/13 06:00
PHST- 2012/07/24 00:00 [received]
PHST- 2012/08/22 00:00 [accepted]
PHST- 2012/09/13 06:00 [entrez]
PHST- 2012/09/13 06:00 [pubmed]
PHST- 2013/01/30 06:00 [medline]
AID - 1471-2261-12-73 [pii]
AID - 10.1186/1471-2261-12-73 [doi]
PST - epublish
SO  - BMC Cardiovasc Disord. 2012 Sep 11;12:73. doi: 10.1186/1471-2261-12-73.


PMID- 22966820
OWN - NLM
STAT- MEDLINE
DCOM- 20130506
LR  - 20220410
IS  - 1471-2458 (Electronic)
IS  - 1471-2458 (Linking)
VI  - 12
DP  - 2012 Sep 11
TI  - Oral health status and behaviours of preschool children in Hong Kong.
PG  - 767
LID - 10.1186/1471-2458-12-767 [doi]
AB  - BACKGROUND: Dental caries is a major public health problem in many countries.
      Since the last territority-wide dental survey of Hong Kong preschool children was
      conducted in 2001, a survey to update the information is necessary. This study
      aimed to describe the dental caries experience of preschool children in Hong Kong
      and factors affecting their dental caries status. METHODS: A stratified random
      sample of children from seven kindergartens in Hong Kong was surveyed in 2009.
      Ethical approval from IRB and parental consent was obtained. Clinical
      examinations of the children were performed by two calibrated examiners using
      disposable dental mirrors, an intra-oral LED light and ball-ended periodontal
      probes. A questionnaire to investigate possible explanatory factors for caries
      status was completed by the children's parents. Caries experience was recorded
      using the dmft index. Multifactor-ANOVA was used to study the relationship
      between dental caries experience, and the background and oral health-related
      behaviours of the children. RESULTS: Seven hundred children (53% boys), mean age 
      5.3 +/- 0.7 years were examined. The mean dmft score of the surveyed children was
      2.2 and 51% of them had no caries experience (dmft = 0). Most (>95%) of the
      decayed teeth were untreated. Statistically significant correlations were found
      between dental caries experience of the children and their oral health-related
      habits, family income, parental education level and parental dental knowledge.
      CONCLUSIONS: Early childhood dental caries was prevalent among the preschool
      children in Hong Kong. Their caries experience was associated with their oral
      health-related behaviours, socio-economic background, and parental education and 
      dental knowledge.
FAU - Chu, Chun-Hung
AU  - Chu CH
AD  - Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.
      chchu@hku.hk
FAU - Ho, Ping-Lit
AU  - Ho PL
FAU - Lo, Edward C M
AU  - Lo EC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120911
PL  - England
TA  - BMC Public Health
JT  - BMC public health
JID - 100968562
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Dental Caries/epidemiology
MH  - Female
MH  - *Health Behavior
MH  - *Health Status
MH  - Hong Kong/epidemiology
MH  - Humans
MH  - Male
MH  - *Oral Health
MH  - Surveys and Questionnaires
PMC - PMC3490858
EDAT- 2012/09/13 06:00
MHDA- 2013/05/07 06:00
CRDT- 2012/09/13 06:00
PHST- 2012/03/12 00:00 [received]
PHST- 2012/08/02 00:00 [accepted]
PHST- 2012/09/13 06:00 [entrez]
PHST- 2012/09/13 06:00 [pubmed]
PHST- 2013/05/07 06:00 [medline]
AID - 1471-2458-12-767 [pii]
AID - 10.1186/1471-2458-12-767 [doi]
PST - epublish
SO  - BMC Public Health. 2012 Sep 11;12:767. doi: 10.1186/1471-2458-12-767.


PMID- 22966773
OWN - NLM
STAT- MEDLINE
DCOM- 20130207
LR  - 20161215
IS  - 0022-0124 (Print)
IS  - 0022-0124 (Linking)
VI  - 43
IP  - 11
DP  - 2012 Nov
TI  - Nurses' perceived benefits, barriers, and educational recommendations for using
      family pedigrees in clinical practice.
PG  - 509-17
LID - 10.3928/00220124-20120904-36 [doi]
AB  - BACKGROUND: There is growing emphasis on the use of genetics and genomics,
      including family pedigrees, in nursing education. This study explored nurses'
      perceptions of the benefits, barriers, and educational recommendations related to
      family pedigrees. METHODS: A qualitative design using focus group methods was
      used to gather data from a convenience sample of 28 nurses working at a large
      medical center in the Midwestern United States. RESULTS: Nurses believed that
      factors supporting the use of family pedigrees are clearly identified patient
      benefits, an electronic tool initiated in primary care, and use by multiple
      disciplines. Barriers include lack of ongoing support and possible ethical,
      legal, social, and cultural issues. Educational recommendations include
      clinically relevant patient and family decision making regarding care.
      CONCLUSION: These nurses had positive perceptions of the use of family pedigrees 
      in clinical nursing practice. They identified a need for education and stressed
      the importance of specialty-specific case examples to maximize relevance.
CI  - Copyright 2012, SLACK Incorporated.
FAU - Pestka, Elizabeth L
AU  - Pestka EL
AD  - Mayo Clinic, Rochester, MN, USA. pestka.elizabeth@mayo.edu
FAU - Meiers, Sonja J
AU  - Meiers SJ
FAU - Shah, Lisa L
AU  - Shah LL
FAU - Junglen, Laura M
AU  - Junglen LM
FAU - Delgado, Adriana
AU  - Delgado A
LA  - eng
PT  - Journal Article
DEP - 20120911
PL  - United States
TA  - J Contin Educ Nurs
JT  - Journal of continuing education in nursing
JID - 0262321
MH  - Adult
MH  - Attitude of Health Personnel
MH  - Education, Nursing, Continuing/*methods
MH  - Female
MH  - Genetic Diseases, Inborn/*genetics/*nursing
MH  - Genomics/*education
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nursing Evaluation Research
MH  - Pedigree
MH  - Primary Care Nursing/*methods
MH  - Young Adult
EDAT- 2012/09/13 06:00
MHDA- 2013/02/08 06:00
CRDT- 2012/09/13 06:00
PHST- 2012/05/31 00:00 [received]
PHST- 2012/08/10 00:00 [accepted]
PHST- 2012/09/13 06:00 [entrez]
PHST- 2012/09/13 06:00 [pubmed]
PHST- 2013/02/08 06:00 [medline]
AID - 10.3928/00220124-20120904-36 [doi]
PST - ppublish
SO  - J Contin Educ Nurs. 2012 Nov;43(11):509-17. doi: 10.3928/00220124-20120904-36.
      Epub 2012 Sep 11.


PMID- 22966730
OWN - NLM
STAT- MEDLINE
DCOM- 20121004
LR  - 20210105
IS  - 1210-7778 (Print)
IS  - 1210-7778 (Linking)
VI  - 20
IP  - 2
DP  - 2012 Jun
TI  - Public health ethical perspectives on the values of the European Commission's
      White Paper "Together for Health".
PG  - 95-100
AB  - BACKGROUND: In 2007 the European Commission issued the White Paper: "Together for
      Health". Considered the EU Health Strategy for the years 2008-2013, it offers the
      cornerstones for setting priorities in EU health actions. OBJECTIVES: The public 
      health framework offered in this strategy is explicitly built on shared
      values--including the overarching values of universality, access to good quality 
      care, equity and solidarity that reacted to certain health care challenges within
      the EU. This article analyses the Health Strategy via its ethical scope and
      considers implications for future health policy making. METHODS: The Health
      Strategy and related documents are scrutinised to explore how the mentioned
      values are defined and enfolded. Additionally, scientific databases are searched 
      for critical discussions of the value base of the Health Strategy. The results
      are discussed and reasoned from a public health ethical perspective. RESULTS: The
      Health Strategy is barely documented and discussed in the scientific literature. 
      Furthermore, no attention was given to the value base of the Health Strategy. Our
      analysis shows that the mentioned values are particularly focussed on health care
      in general rather than on public health in particular. Besides this, the given
      values of the Health Strategy are redundant. CONCLUSIONS: An additional
      consideration of consequentialist public health ethics values would normatively
      strengthen a population-based health approach of EU health policy making.
FAU - Schroder-Back, Peter
AU  - Schroder-Back P
AD  - Department of International Health, Maastricht University, School CAPHRI,
      Maastricht, The Netherlands. Peter.Schroder@maastrichtuniversity.nl
FAU - Clemens, Timo
AU  - Clemens T
FAU - Michelsen, Kai
AU  - Michelsen K
FAU - Schulte in den Baumen, Tobias
AU  - Schulte in den Baumen T
FAU - Sorensen, Kristine
AU  - Sorensen K
FAU - Borrett, Glenn
AU  - Borrett G
FAU - Brand, Helmut
AU  - Brand H
LA  - eng
PT  - Journal Article
PL  - Czech Republic
TA  - Cent Eur J Public Health
JT  - Central European journal of public health
JID - 9417324
SB  - IM
MH  - *European Union
MH  - *Health Policy
MH  - *Health Priorities
MH  - Health Services Accessibility
MH  - Humans
MH  - Policy Making
MH  - Public Health/*standards
MH  - Quality of Health Care
EDAT- 2012/09/13 06:00
MHDA- 2012/10/05 06:00
CRDT- 2012/09/13 06:00
PHST- 2012/09/13 06:00 [entrez]
PHST- 2012/09/13 06:00 [pubmed]
PHST- 2012/10/05 06:00 [medline]
AID - 10.21101/cejph.a3729 [doi]
PST - ppublish
SO  - Cent Eur J Public Health. 2012 Jun;20(2):95-100. doi: 10.21101/cejph.a3729.


PMID- 22966529
OWN - NLM
STAT- MEDLINE
DCOM- 20121011
LR  - 20120912
IS  - 1092-0811 (Print)
IS  - 1092-0811 (Linking)
VI  - 21
IP  - 4
DP  - 2012 Jul-Aug
TI  - Ethical challenges in the era of health care reform.
PG  - 248-50, 245
FAU - Lachman, Vicki D
AU  - Lachman VD
AD  - Drexel University, College of Nursing and Health Professions, Philadelphia, PA,
      USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medsurg Nurs
JT  - Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses
JID - 9300545
MH  - Chronic Disease
MH  - Electronic Health Records
MH  - Ethics, Medical
MH  - Health Care Reform/*ethics/*legislation & jurisprudence
MH  - Health Policy
MH  - Humans
MH  - Insurance, Health/*economics/*legislation & jurisprudence
MH  - United States
EDAT- 2012/09/13 06:00
MHDA- 2012/10/12 06:00
CRDT- 2012/09/13 06:00
PHST- 2012/09/13 06:00 [entrez]
PHST- 2012/09/13 06:00 [pubmed]
PHST- 2012/10/12 06:00 [medline]
PST - ppublish
SO  - Medsurg Nurs. 2012 Jul-Aug;21(4):248-50, 245.


PMID- 22966498
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20181201
IS  - 0363-6771 (Print)
IS  - 0363-6771 (Linking)
VI  - 60
IP  - 4
DP  - 2012 Jul-Aug
TI  - Revisiting ethics.
PG  - 252-3; author reply 253-4
FAU - Miller, Mark P
AU  - Miller MP
LA  - eng
PT  - Letter
PT  - Comment
PL  - United States
TA  - Gen Dent
JT  - General dentistry
JID - 7610466
CON - Gen Dent. 2012 Mar-Apr;60(2):100-3. PMID: 22414502
MH  - Dental Care/*ethics
MH  - Dentists/*ethics
MH  - *Ethics, Dental
MH  - Humans
MH  - Male
EDAT- 2012/09/13 06:00
MHDA- 2013/02/13 06:00
CRDT- 2012/09/13 06:00
PHST- 2012/09/13 06:00 [entrez]
PHST- 2012/09/13 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
PST - ppublish
SO  - Gen Dent. 2012 Jul-Aug;60(4):252-3; author reply 253-4.


PMID- 22966497
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20181201
IS  - 0363-6771 (Print)
IS  - 0363-6771 (Linking)
VI  - 60
IP  - 4
DP  - 2012 Jul-Aug
TI  - Revisiting ethics.
PG  - 252
FAU - Katkow, Eric
AU  - Katkow E
LA  - eng
PT  - Letter
PT  - Comment
PL  - United States
TA  - Gen Dent
JT  - General dentistry
JID - 7610466
CON - Gen Dent. 2012 Mar-Apr;60(2):100-3. PMID: 22414502
MH  - Dental Care/*ethics
MH  - Dentists/*ethics
MH  - *Ethics, Dental
MH  - Humans
MH  - Male
EDAT- 2012/09/13 06:00
MHDA- 2013/02/13 06:00
CRDT- 2012/09/13 06:00
PHST- 2012/09/13 06:00 [entrez]
PHST- 2012/09/13 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
PST - ppublish
SO  - Gen Dent. 2012 Jul-Aug;60(4):252.


PMID- 22966469
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120912
LR  - 20211021
IS  - 2090-6536 (Electronic)
VI  - 2012
DP  - 2012
TI  - Duodenal tumor presenting as acquired hemophilia in an 88-year-old woman: a
      clinical case and review of the literature.
PG  - 203801
LID - 10.1155/2012/203801 [doi]
AB  - Acquired hemophilia is a rare disease, presenting with severe hemorrhage, we
      present a case caused by a duodenal tumor, the clinical management, ethical
      implications, treatment recommendations, and a review of the literature.
FAU - Murray, Nigel P
AU  - Murray NP
AD  - Facultad de Medicina, Universidad Mayor, Renato Sanchez 4369, Las Condes,
      Santiago 27550224, Chile.
FAU - Moncada, Juan Carlos
AU  - Moncada JC
FAU - Moran, Marcelo
AU  - Moran M
LA  - eng
PT  - Journal Article
DEP - 20120826
PL  - United States
TA  - Case Rep Gastrointest Med
JT  - Case reports in gastrointestinal medicine
JID - 101580185
PMC - PMC3432527
EDAT- 2012/09/12 06:00
MHDA- 2012/09/12 06:01
CRDT- 2012/09/12 06:00
PHST- 2012/05/28 00:00 [received]
PHST- 2012/07/30 00:00 [accepted]
PHST- 2012/09/12 06:00 [entrez]
PHST- 2012/09/12 06:00 [pubmed]
PHST- 2012/09/12 06:01 [medline]
AID - 10.1155/2012/203801 [doi]
PST - ppublish
SO  - Case Rep Gastrointest Med. 2012;2012:203801. doi: 10.1155/2012/203801. Epub 2012 
      Aug 26.


PMID- 22966068
OWN - NLM
STAT- MEDLINE
DCOM- 20130103
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 265
IP  - 2
DP  - 2012 Nov
TI  - Coronary in-stent restenosis: assessment with CT coronary angiography.
PG  - 410-7
LID - 10.1148/radiol.12112363 [doi]
AB  - PURPOSE: To compare accuracy and radiation exposure of a new computed tomographic
      (CT) scanner with improved spatial resolution (scanner A) with those of a CT
      scanner with standard spatial resolution (scanner B) for evaluation of coronary
      in-stent restenosis (ISR) by using invasive coronary angiography (ICA) and
      intravascular ultrasonography (US) as reference methods. MATERIALS AND METHODS:
      Written informed consent was obtained and study protocol was approved by
      institutional ethics committee. A total of 180 consecutive patients (154 men
      [mean age +/- standard deviation, 66 years+/-12; range, 51-79 years] and 36 women
      [mean age, 70 years+/-12; range, 55-83 years]) scheduled to undergo ICA for
      suspected ISR were enrolled. Ninety patients were studied with scanner A (group
      1: 72 men [mean age, 65 years+/-11; range, 52-79], 18 women [mean age, 68
      years+/-12; range, 55-83 years]) and 90 with scanner B (group 2: 74 men [mean
      age, 64 years+/-10; range, 51-77 years], 16 women [mean age, 68 years+/-11;
      range, 55-82 years). Examination with the two scanners was compared with ICA and 
      intravascular US. Radiation dose exposure was estimated. To compare stent
      evaluability between the two groups, chi2 test was used. RESULTS: Stent
      evaluability was higher in group 1 than in group 2 (99% vs 92%, P=.0021). A
      significantly lower rate of beam-hardening artifact was observed in group 1 (two 
      cases) than group 2 (12 cases, P<.05). For stent-based analysis, sensitivity,
      specificity, and accuracy of multidetector CT for ISR identification were 96%,
      95%, and 96% in group 1 and 90%, 91%, and 91% in group 2, respectively, without
      statistically significant differences. The correlation between percent ISR
      evaluated at multidetector CT versus intravascular US was higher in group 1 than 
      in group 2 (r=0.89 vs r=0.58; P=.019). The correlations of diameter and area
      measurements at reference site and stent maximal lumen narrowing site between
      multidetector CT and intravascular US were higher in group 1 than in group 2.
      Radiation dose was low in both multidetector CT groups (1.9 mSv+/-0.2).
      CONCLUSION: Scanner A, with improved spatial resolution, allowed reliable
      detection and quantification of coronary ISR with low radiation exposure.
CI  - (c) RSNA, 2012
FAU - Andreini, Daniele
AU  - Andreini D
AD  - Department of Cardiovascular Imaging, Centro Cardiologico Monzino, IRCCS, Via C. 
      Parea 4, 20138 Milan, Italy. daniele.andreini@ccfm.it
FAU - Pontone, Gianluca
AU  - Pontone G
FAU - Mushtaq, Saima
AU  - Mushtaq S
FAU - Bartorelli, Antonio L
AU  - Bartorelli AL
FAU - Bertella, Erika
AU  - Bertella E
FAU - Trabattoni, Daniela
AU  - Trabattoni D
FAU - Montorsi, Piero
AU  - Montorsi P
FAU - Galli, Stefano
AU  - Galli S
FAU - Foti, Claudia
AU  - Foti C
FAU - Annoni, Andrea
AU  - Annoni A
FAU - Bovis, Francesca
AU  - Bovis F
FAU - Ballerini, Giovanni
AU  - Ballerini G
FAU - Agostoni, Piergiuseppe
AU  - Agostoni P
FAU - Fiorentini, Cesare
AU  - Fiorentini C
FAU - Pepi, Mauro
AU  - Pepi M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20120910
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
CIN - Radiology. 2013 Apr;267(1):315-6. PMID: 23525721
CIN - Rofo. 2013 Apr;185(4):310-1. PMID: 23553391
CIN - Radiology. 2013 Apr;267(1):316-7. PMID: 23641489
MH  - Aged
MH  - Coronary Angiography/*methods
MH  - Coronary Restenosis/*diagnostic imaging/*etiology
MH  - Female
MH  - Graft Occlusion, Vascular/*diagnostic imaging/*etiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Radiographic Image Enhancement/*methods
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Stents/*adverse effects
MH  - Tomography, X-Ray Computed/methods
EDAT- 2012/09/12 06:00
MHDA- 2013/01/04 06:00
CRDT- 2012/09/12 06:00
PHST- 2012/09/12 06:00 [entrez]
PHST- 2012/09/12 06:00 [pubmed]
PHST- 2013/01/04 06:00 [medline]
AID - radiol.12112363 [pii]
AID - 10.1148/radiol.12112363 [doi]
PST - ppublish
SO  - Radiology. 2012 Nov;265(2):410-7. doi: 10.1148/radiol.12112363. Epub 2012 Sep 10.


PMID- 22965934
OWN - NLM
STAT- MEDLINE
DCOM- 20130522
LR  - 20131127
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 20
IP  - 1
DP  - 2013 Feb
TI  - Talking about suicide: confidentiality and anonymity in qualitative research.
PG  - 18-29
LID - 10.1177/0969733012452684 [doi]
AB  - While it is acknowledged that there is a need for more qualitative research on
      suicide, it is also clear that the ethics of undertaking such research need to be
      addressed. This article uses the case study of the authors' experience of gaining
      ethics approval for a research project that asks people what it is like to feel
      suicidal to (a) analyse the limits of confidentiality and anonymity and (b)
      consider the ways in which the process of ethics review can shape and constrain
      suicide research. This leads to a discussion of the ways in which ethics
      committees assess and monitor qualitative research more generally and some
      preliminary suggestions for how this might be improved.
FAU - Gibson, Susanne
AU  - Gibson S
AD  - SANE, London, UK. sgibson@sane.org.uk
FAU - Benson, Outi
AU  - Benson O
FAU - Brand, Sarah L
AU  - Brand SL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120910
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Biomedical Research/*ethics/standards
MH  - Confidentiality/*standards
MH  - *Ethics Committees, Research
MH  - Humans
MH  - Organizational Case Studies
MH  - *Personal Autonomy
MH  - Qualitative Research
MH  - *Suicide
EDAT- 2012/09/12 06:00
MHDA- 2013/05/23 06:00
CRDT- 2012/09/12 06:00
PHST- 2012/09/12 06:00 [entrez]
PHST- 2012/09/12 06:00 [pubmed]
PHST- 2013/05/23 06:00 [medline]
AID - 0969733012452684 [pii]
AID - 10.1177/0969733012452684 [doi]
PST - ppublish
SO  - Nurs Ethics. 2013 Feb;20(1):18-29. doi: 10.1177/0969733012452684. Epub 2012 Sep
      10.


PMID- 22965865
OWN - NLM
STAT- MEDLINE
DCOM- 20131230
LR  - 20151119
IS  - 1471-8405 (Electronic)
IS  - 0962-7480 (Linking)
VI  - 62
IP  - 7
DP  - 2012 Oct
TI  - Occupational physicians' perceptions and impact of 2009 GMC consent guidelines.
PG  - 560-2
LID - 10.1093/occmed/kqs147 [doi]
AB  - BACKGROUND: In 2009, the General Medical Council (GMC) updated its guidance on
      consent, introducing a new statement that employees should be offered the
      opportunity to view reports, before the reports are sent to the employer. AIMS:
      To investigate the effects of this change on the perceptions and practice of
      occupational physicians. METHODS: A cross-sectional survey of UK occupational
      physicians via the Society of Occupational Medicine e-newsletter, seeking their
      opinions of the anticipated and actual effects of the guidance on employers,
      employees, occupational physicians and occupational health services. RESULTS: Two
      hundred and ninety-five completed questionnaires were returned (estimated
      response rate 30%). Respondents included 25% of accredited UK specialists. Some
      reported improved standards and greater transparency, however the change was
      generally perceived as unfavourable, with employee and employer losses: 50%
      reported delay providing timely advice to employers and 35% reported delays in
      employees returning to work. Significant variation in practice and increased
      costs were reported, with variable effects on different services. Difficulties in
      areas such as pensions and health surveillance were reported. Some occupational
      physicians had moved to instant reporting; others had moved away from this to
      allow more care with wording of reports. CONCLUSIONS: We found significant
      variations in practice between occupational physicians and concerns of employee
      and employer losses as a result of changes to the GMC consent guidance. Clearer
      guidance on practical implementation was desired. The background ethical
      reasoning should be stated so that the parameters of the guidance are delineated 
      and its reach should be clarified.
FAU - Stern, A F
AU  - Stern AF
AD  - Nexus Healthcare Limited, Churchill House, Hendon, London, UK.
      anna.stern@nexushealthcare.co.uk
FAU - Sperber, S
AU  - Sperber S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120910
PL  - England
TA  - Occup Med (Lond)
JT  - Occupational medicine (Oxford, England)
JID - 9205857
SB  - IM
MH  - Analysis of Variance
MH  - *Attitude of Health Personnel
MH  - Cross-Sectional Studies
MH  - England/epidemiology
MH  - Female
MH  - Guidelines as Topic
MH  - Humans
MH  - Male
MH  - Occupational Medicine/ethics/*standards
MH  - *Physicians
MH  - Social Perception
MH  - Surveys and Questionnaires
EDAT- 2012/09/12 06:00
MHDA- 2014/01/01 06:00
CRDT- 2012/09/12 06:00
PHST- 2012/09/12 06:00 [entrez]
PHST- 2012/09/12 06:00 [pubmed]
PHST- 2014/01/01 06:00 [medline]
AID - kqs147 [pii]
AID - 10.1093/occmed/kqs147 [doi]
PST - ppublish
SO  - Occup Med (Lond). 2012 Oct;62(7):560-2. doi: 10.1093/occmed/kqs147. Epub 2012 Sep
      10.


PMID- 22965167
OWN - NLM
STAT- MEDLINE
DCOM- 20130206
LR  - 20211021
IS  - 1759-5037 (Electronic)
IS  - 1759-5029 (Linking)
VI  - 8
IP  - 10
DP  - 2012 Oct
TI  - Ethics: Genetic testing for MEN1--whose responsibility?
PG  - 575-6
LID - 10.1038/nrendo.2012.164 [doi]
FAU - Lips, Cornelis J M
AU  - Lips CJ
FAU - Hoppener, Jo W M
AU  - Hoppener JW
LA  - eng
PT  - News
DEP - 20120911
PL  - England
TA  - Nat Rev Endocrinol
JT  - Nature reviews. Endocrinology
JID - 101500078
RN  - 0 (MEN1 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Genetic Testing/*ethics
MH  - Humans
MH  - Multiple Endocrine Neoplasia Type 1/*diagnosis/*genetics
MH  - Mutation
MH  - Proto-Oncogene Proteins/genetics
EDAT- 2012/09/12 06:00
MHDA- 2013/02/07 06:00
CRDT- 2012/09/12 06:00
PHST- 2012/09/12 06:00 [entrez]
PHST- 2012/09/12 06:00 [pubmed]
PHST- 2013/02/07 06:00 [medline]
AID - nrendo.2012.164 [pii]
AID - 10.1038/nrendo.2012.164 [doi]
PST - ppublish
SO  - Nat Rev Endocrinol. 2012 Oct;8(10):575-6. doi: 10.1038/nrendo.2012.164. Epub 2012
      Sep 11.


PMID- 22964603
OWN - NLM
STAT- MEDLINE
DCOM- 20130201
LR  - 20181201
IS  - 1536-0911 (Electronic)
IS  - 1536-0903 (Linking)
VI  - 12
IP  - 5
DP  - 2012 Oct
TI  - NICU nurses' lived experience: caring for infants with neonatal abstinence
      syndrome.
PG  - 281-5
LID - 10.1097/ANC.0b013e3182677bc1 [doi]
AB  - PURPOSE: The primary aim of this qualitative methods study was to describe the
      lived experiences of neonatal intensive care unit (NICU) nurses with ethical and 
      morally challenging issues. SUBJECTS: The target population for the study was
      registered nurses working in the NICU. Interviews were completed with 16 nurses
      from 1 hospital. DESIGN: A phenomenological method design was used to describe
      NICU nurses' lived experiences with ethical and moral issues encountered in the
      NICU. METHODS: After obtaining signed consent, the principal investigator
      interviewed all participants, using a semistructured interview guide consisting
      of open-ended questions. MAIN OUTCOMES: Ethical and moral distress related to
      neonatal abstinence syndrome was the predominant outcome. PRINCIPAL RESULTS:
      Caring for infants, coping with families, and discharging infants home were the
      major concerns voiced by nurses in this study. CONCLUSIONS: Nurses in this study 
      struggled with issues of beneficence and nonmaleficence and were not aware of
      scientific evidence that guides methadone management of pregnant women.
FAU - Maguire, Denise
AU  - Maguire D
AD  - College of Nursing, University of South Florida, Tampa, FL 33612, USA.
      dmaguire@health.usf.edu
FAU - Webb, Mary
AU  - Webb M
FAU - Passmore, Denise
AU  - Passmore D
FAU - Cline, Genieveve
AU  - Cline G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Adv Neonatal Care
JT  - Advances in neonatal care : official journal of the National Association of
      Neonatal Nurses
JID - 101125644
SB  - IM
MH  - Adaptation, Psychological
MH  - Attitude of Health Personnel
MH  - Clinical Competence
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Intensive Care Units, Neonatal
MH  - Intensive Care, Neonatal/ethics/methods/standards
MH  - Moral Obligations
MH  - *Neonatal Abstinence Syndrome/etiology/nursing
MH  - *Neonatal Nursing/ethics/methods
MH  - *Nurses/psychology/standards
MH  - Nursing Assessment
MH  - Opiate Substitution Treatment/methods/nursing
MH  - Patient Discharge
MH  - Pregnancy
MH  - Pregnancy Complications/*nursing
MH  - Professional-Family Relations
MH  - *Substance-Related Disorders/complications/nursing
MH  - Surveys and Questionnaires
MH  - Workforce
EDAT- 2012/09/12 06:00
MHDA- 2013/02/05 06:00
CRDT- 2012/09/12 06:00
PHST- 2012/09/12 06:00 [entrez]
PHST- 2012/09/12 06:00 [pubmed]
PHST- 2013/02/05 06:00 [medline]
AID - 10.1097/ANC.0b013e3182677bc1 [doi]
AID - 00149525-201210000-00007 [pii]
PST - ppublish
SO  - Adv Neonatal Care. 2012 Oct;12(5):281-5. doi: 10.1097/ANC.0b013e3182677bc1.


PMID- 22963922
OWN - NLM
STAT- MEDLINE
DCOM- 20130510
LR  - 20121120
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 75
IP  - 12
DP  - 2012 Dec
TI  - What counts and how to count it: physicians' constructions of evidence in a
      disinvestment context.
PG  - 2191-9
LID - 10.1016/j.socscimed.2012.08.016 [doi]
LID - S0277-9536(12)00622-3 [pii]
AB  - Internationally, there is an increasing focus on quality and sustainability
      measures oriented to reducing inefficiencies in health provision. The use of
      assisted reproductive technologies (ART) for older women represents a case study 
      in this area. This paper analyses the constructions of evidence brought to bear
      by ART physicians in the context of deliberative stakeholder engagements (held
      2010) around options for restricting public subsidy of ART in Australia.
      Physicians participated in two deliberative engagements during which they were
      presented with results of a systematic review of ART effectiveness, as well as
      ethical and cost analyses. These sessions were part of a broader research program
      of engagements held with policymakers, community members and consumers.
      Physicians deliberated around the data presented with a view to formulating an
      informed contribution to policy. The ensuing discussions were transcribed and
      subject to discourse analysis. Physicians questioned the evidence presented on
      the grounds of 'currency', 'proximity', 'selectivity' and 'bias'. We outline
      physicians' accounts of what should count as evidence informing ART policy, and
      how this evidence should be counted. These accounts reflect implicit decisions
      around both the inclusion of evidence (selection) and the status it is accorded
      (evaluation). Our analysis suggests that participatory policy processes do not
      represent the simple task of assessing the quality/effectiveness of a given
      technology against self-evident criteria. Rather, these processes involve the
      negotiation of different orders of evidence (empirical, contextual and
      anecdotal), indicating a need for higher-level discussion around 'what counts and
      how to count it' when making disinvestment decisions.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Hodgetts, Katherine
AU  - Hodgetts K
AD  - School of Population Health and Clinical Practice, The University of Adelaide,
      North Terrace, Adelaide 5005, SA, Australia.
FAU - Elshaug, Adam G
AU  - Elshaug AG
FAU - Hiller, Janet E
AU  - Hiller JE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120827
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Australia
MH  - *Evidence-Based Medicine
MH  - Female
MH  - *Health Policy
MH  - Humans
MH  - Male
MH  - National Health Programs/economics
MH  - Physicians/*psychology
MH  - Reproductive Techniques, Assisted/*economics
EDAT- 2012/09/12 06:00
MHDA- 2013/05/11 06:00
CRDT- 2012/09/12 06:00
PHST- 2011/12/20 00:00 [received]
PHST- 2012/07/27 00:00 [revised]
PHST- 2012/08/17 00:00 [accepted]
PHST- 2012/09/12 06:00 [entrez]
PHST- 2012/09/12 06:00 [pubmed]
PHST- 2013/05/11 06:00 [medline]
AID - S0277-9536(12)00622-3 [pii]
AID - 10.1016/j.socscimed.2012.08.016 [doi]
PST - ppublish
SO  - Soc Sci Med. 2012 Dec;75(12):2191-9. doi: 10.1016/j.socscimed.2012.08.016. Epub
      2012 Aug 27.


PMID- 22963760
OWN - NLM
STAT- MEDLINE
DCOM- 20140122
LR  - 20220129
IS  - 1555-3892 (Electronic)
IS  - 0963-6897 (Linking)
VI  - 22
IP  - 7
DP  - 2013
TI  - Survival and functional restoration of human fetal ventral mesencephalon
      following transplantation in a rat model of Parkinson's disease.
PG  - 1281-93
LID - 10.3727/096368912X654984 [doi]
AB  - Cell replacement therapy by intracerebral transplantation of fetal dopaminergic
      neurons has become a promising therapeutic option for patients suffering from
      Parkinson's disease during the last decades. However, limited availability of
      human fetal tissue as well as ethical issues, lack of alternative nonfetal donor 
      cells, and the absence of standardized transplantation protocols have prevented
      neurorestorative therapies from becoming a routine procedure in patients
      suffering from neurodegenerative diseases. Improvement of graft survival, surgery
      techniques, and identification of the optimal target area are imperative for
      further optimization of this novel treatment. In the present study, human primary
      fetal ventral mesencephalon-derived tissue from 7- to 9-week-old human fetuses
      was transplanted into 6-hydroxydopamine-lesioned adult Sprague-Dawley rats. Graft
      survival, fiber outgrowth, and drug-induced rotational behavior up to 14 weeks
      posttransplantation were compared between different intrastriatal transplantation
      techniques (full single cell suspension vs. partial tissue pieces suspension
      injected by glass capillary or metal cannula) and the intranigral glass capillary
      injection of a full (single cell) suspension. The results demonstrate a higher
      survival rate of dopamine neurons, a greater reduction in amphetamine-induced
      rotations (overcompensation), and more extensive fiber outgrowth for the
      intrastriatally transplanted partial (tissue pieces) suspension compared to all
      other groups. Apomorphine-induced rotational bias was significantly reduced in
      all groups including the intranigral group. The data confirm that human ventral
      mesencephalon-derived cells serve as a viable cell source, survive in a
      xenografting paradigm, and functionally integrate into the host tissue. In
      contrast to rat donor cells, keeping the original (fetal) neuronal network by
      preparing only a partial suspension containing tissue pieces seems to be
      beneficial for human cells, although a metal cannula that causes greater tissue
      trauma to the host is required for injection. In addition, homotopic intranigral 
      grafts may represent a complimentary grafting approach to the "classical" ectopic
      intrastriatal target site in PD.
FAU - Rath, Anika
AU  - Rath A
AD  - Department of Stereotactic and Functional Neurosurgery, Neurocentre, University
      of Freiburg, Freiburg, Germany.
FAU - Klein, Alexander
AU  - Klein A
FAU - Papazoglou, Anna
AU  - Papazoglou A
FAU - Pruszak, Jan
AU  - Pruszak J
FAU - Garcia, Joanna
AU  - Garcia J
FAU - Krause, Martin
AU  - Krause M
FAU - Maciaczyk, Jaroslaw
AU  - Maciaczyk J
FAU - Dunnett, Stephen B
AU  - Dunnett SB
FAU - Nikkhah, Guido
AU  - Nikkhah G
LA  - eng
GR  - G0800394/MRC_/Medical Research Council/United Kingdom
GR  - G1001257/MRC_/Medical Research Council/United Kingdom
GR  - J-0703/PUK_/Parkinson's UK/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120907
PL  - United States
TA  - Cell Transplant
JT  - Cell transplantation
JID - 9208854
RN  - 8HW4YBZ748 (Oxidopamine)
RN  - EC 1.14.16.2 (Tyrosine 3-Monooxygenase)
RN  - N21FAR7B4S (Apomorphine)
SB  - IM
MH  - Animals
MH  - Apomorphine/pharmacology
MH  - Behavior, Animal/drug effects
MH  - Disease Models, Animal
MH  - Embryo, Mammalian/cytology
MH  - Female
MH  - Graft Survival
MH  - Humans
MH  - Mesencephalon/*cytology/transplantation
MH  - Neurons/metabolism/pathology
MH  - Oxidopamine/pharmacology
MH  - Parkinson Disease/metabolism/*therapy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Transplantation, Heterologous
MH  - Tyrosine 3-Monooxygenase/metabolism
EDAT- 2012/09/12 06:00
MHDA- 2014/01/23 06:00
CRDT- 2012/09/12 06:00
PHST- 2012/09/12 06:00 [entrez]
PHST- 2012/09/12 06:00 [pubmed]
PHST- 2014/01/23 06:00 [medline]
AID - ct0563rath [pii]
AID - 10.3727/096368912X654984 [doi]
PST - ppublish
SO  - Cell Transplant. 2013;22(7):1281-93. doi: 10.3727/096368912X654984. Epub 2012 Sep
      7.


PMID- 22963689
OWN - NLM
STAT- MEDLINE
DCOM- 20121210
LR  - 20211021
IS  - 1476-069X (Electronic)
IS  - 1476-069X (Linking)
VI  - 11
DP  - 2012 Sep 10
TI  - Taking action on developmental toxicity: scientists' duties to protect children.
PG  - 61
LID - 10.1186/1476-069X-11-61 [doi]
AB  - BACKGROUND: Although adaptation and proper biological functioning require
      developmental programming, pollutant interference can cause developmental
      toxicity or DT. OBJECTIVES: This commentary assesses whether it is ethical for
      citizens/physicians/scientists to allow avoidable DT. METHODS: Using conceptual, 
      economic, ethical, and logical analysis, the commentary assesses what major
      ethical theories and objectors would say regarding the defensibility of allowing 
      avoidable DT. RESULTS: The commentary argues that (1) none of the four major
      ethical theories (based, respectively, on virtue, natural law, utility, or
      equity) can consistently defend avoidable DT because it unjustifiably harms,
      respectively, individual human flourishing, human life, the greatest good, and
      equality. (2) Justice also requires leaving "as much and as good" biological
      resources for all, including future generations possibly harmed if epigenetic
      change is heritable. (3) Scientists/physicians have greater justice-based duties,
      than ordinary/average citizens, to help stop DT because they help cause it and
      have greater professional abilities/opportunities to help stop it. (4)
      Scientists/physicians likewise have greater justice-based duties, than
      ordinary/average citizens, to help stop DT because they benefit more from it,
      given their relatively greater education/consumption/income. The paper shows that
      major objections to (3)-(4) fail on logical, ethical, or scientific grounds, then
      closes with practical suggestions for implementing its proposals. CONCLUSIONS:
      Because allowing avoidable DT is ethically indefensible, citizens---and
      especially physicians/scientists---have justice-based duties to help stop DT.
FAU - Shrader-Frechette, Kristin
AU  - Shrader-Frechette K
AD  - Department of Biological Sciences, University of Notre Dame, Notre Dame, IN
      46556, USA. kshrader@nd.edu
LA  - eng
PT  - Editorial
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20120910
PL  - England
TA  - Environ Health
JT  - Environmental health : a global access science source
JID - 101147645
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - *Environmental Exposure
MH  - Environmental Pollutants/*toxicity
MH  - Epigenomics
MH  - Human Development/*drug effects
MH  - Humans
MH  - Public Health/*ethics
MH  - Toxicology/*ethics
PMC - PMC3444422
EDAT- 2012/09/12 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/09/12 06:00
PHST- 2012/05/31 00:00 [received]
PHST- 2012/08/15 00:00 [accepted]
PHST- 2012/09/12 06:00 [entrez]
PHST- 2012/09/12 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - 1476-069X-11-61 [pii]
AID - 10.1186/1476-069X-11-61 [doi]
PST - epublish
SO  - Environ Health. 2012 Sep 10;11:61. doi: 10.1186/1476-069X-11-61.


PMID- 22963567
OWN - NLM
STAT- MEDLINE
DCOM- 20130610
LR  - 20220309
IS  - 1875-533X (Electronic)
IS  - 0929-8673 (Linking)
VI  - 19
IP  - 35
DP  - 2012
TI  - The use of stem cells in regenerative medicine for Parkinson's and Huntington's
      Diseases.
PG  - 6018-35
AB  - Cell transplantation has been proposed as a means of replacing specific cell
      populations lost through neurodegenerative processes such as that seen in
      Parkinson's or Huntington's diseases. Improvement of the clinical symptoms has
      been observed in a number of Parkinson and Huntington's patients transplanted
      with freshly isolated fetal brain tissue but such restorative approach is greatly
      hampered by logistic and ethical concerns relative to the use of fetal tissue, in
      addition to potential side effects that remain to be controlled. In this context,
      stem cells that are capable of self-renewal and can differentiate into neurons,
      have received a great deal of interest, as demonstrated by the numerous studies
      based on the transplantation of neural stem/progenitor cells, embryonic stem
      cells or mesenchymal stem cells into animal models of Parkinson's or Huntington's
      diseases. More recently, the induction of pluripotent stem cells from somatic
      adult cells has raised a new hope for the treatment of neurodegenerative
      diseases. In the present article, we review the main experimental approaches to
      assess the efficiency of cell-based therapy for Parkinson's or Huntington's
      diseases, and discuss the recent advances in using stem cells to replace lost
      dopaminergic mesencephalic or striatal neurons. Characteristics of the different 
      stem cells are extensively examined with a special attention to their ability of 
      producing neurotrophic or immunosuppressive factors, as these may provide a
      favourable environment for brain tissue repair and long-term survival of
      transplanted cells in the central nervous system. Thus, stem cell therapy can be 
      a valuable tool in regenerative medicine.
FAU - Lescaudron, L
AU  - Lescaudron L
AD  - LUNAM Universite, France. Laurent.Lescaudron@univ-nantes.fr
FAU - Naveilhan, P
AU  - Naveilhan P
FAU - Neveu, I
AU  - Neveu I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Curr Med Chem
JT  - Current medicinal chemistry
JID - 9440157
RN  - 0 (Nerve Growth Factors)
SB  - IM
MH  - Animals
MH  - Dopaminergic Neurons/metabolism
MH  - Embryonic Stem Cells/cytology/transplantation
MH  - Humans
MH  - Huntington Disease/genetics/metabolism/*therapy
MH  - Induced Pluripotent Stem Cells/cytology/transplantation
MH  - Mesenchymal Stem Cells/cytology
MH  - Nerve Growth Factors/metabolism
MH  - Neural Stem Cells/cytology/transplantation
MH  - Parkinson Disease/genetics/metabolism/*therapy
MH  - Regenerative Medicine
MH  - Stem Cell Transplantation
MH  - Stem Cells/*cytology
EDAT- 2012/09/12 06:00
MHDA- 2013/06/12 06:00
CRDT- 2012/09/12 06:00
PHST- 2012/02/29 00:00 [received]
PHST- 2012/05/15 00:00 [revised]
PHST- 2012/05/31 00:00 [accepted]
PHST- 2012/09/12 06:00 [entrez]
PHST- 2012/09/12 06:00 [pubmed]
PHST- 2013/06/12 06:00 [medline]
AID - CMC-EPUB-20120903-38 [pii]
PST - ppublish
SO  - Curr Med Chem. 2012;19(35):6018-35.


PMID- 22963422
OWN - NLM
STAT- MEDLINE
DCOM- 20130301
LR  - 20181201
IS  - 1935-990X (Electronic)
IS  - 0003-066X (Linking)
VI  - 67
IP  - 6
DP  - 2012 Sep
TI  - Knowing what we do not know about sexual orientation change efforts.
PG  - 498-9
LID - 10.1037/a0029683 [doi]
AB  - Comments on the original article, "Guidelines for psychological practice with
      lesbian, gay, and bisexual clients," by the American Psychological Association
      (see record 2011-19419-001). The present authors notes that the APA has provided 
      a very helpful document for those who do clinical work with individuals
      experiencing same-sex attractions. Psychologists no doubt need to be familiar
      with the literature described in these guidelines as a part of ethical practice. 
      However, the present authors register concern regarding how the guidelines
      address sexual orientation change efforts (SOCE). They focus their critique on
      how the guidelines portray two issues pertaining to SOCE-effectiveness and
      harm-and conclude with a proposal to move the discussion forward via science.
CI  - (PsycINFO Database Record (c) 2012 APA, all rights reserved).
FAU - Rosik, Christopher H
AU  - Rosik CH
AD  - Link Care Center, 1734 West Shaw Avenue, Fresno, CA 93711, USA.
      christopherrosik@linkcare.org
FAU - Jones, Stanton L
AU  - Jones SL
FAU - Byrd, A Dean
AU  - Byrd AD
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am Psychol
JT  - The American psychologist
JID - 0370521
SB  - IM
CON - Am Psychol. 2012 Jan;67(1):10-42. PMID: 21875169
MH  - Bisexuality/*psychology
MH  - Female
MH  - Homosexuality, Female/*psychology
MH  - Homosexuality, Male/*psychology
MH  - Humans
MH  - Male
MH  - Mental Disorders/*therapy
MH  - Psychotherapy/*methods
EDAT- 2012/09/12 06:00
MHDA- 2013/03/02 06:00
CRDT- 2012/09/12 06:00
PHST- 2012/09/12 06:00 [entrez]
PHST- 2012/09/12 06:00 [pubmed]
PHST- 2013/03/02 06:00 [medline]
AID - 2012-24333-010 [pii]
AID - 10.1037/a0029683 [doi]
PST - ppublish
SO  - Am Psychol. 2012 Sep;67(6):498-9. doi: 10.1037/a0029683.


PMID- 22963378
OWN - NLM
STAT- MEDLINE
DCOM- 20130712
LR  - 20211021
IS  - 1471-2407 (Electronic)
IS  - 1471-2407 (Linking)
VI  - 12
DP  - 2012 Sep 10
TI  - EXERCISE in pediatric autologous stem cell transplant patients: a randomized
      controlled trial protocol.
PG  - 401
LID - 10.1186/1471-2407-12-401 [doi]
AB  - BACKGROUND: Hematopoietic stem cell transplantation is an intensive therapy used 
      to improve survivorship and cure various oncologic diseases. However, this
      therapy is associated with high mortality rates and numerous negative
      side-effects. The recovery of the immune system is a special concern and plays a 
      key role in the success of this treatment. In healthy populations it is known
      that exercise plays an important role in immune system regulation, but little is 
      known about the role of exercise in the hematological and immunological recovery 
      of children undergoing hematopoietic stem cell transplant. The primary objective 
      of this randomized-controlled trial (RCT) is to study the effect of an exercise
      program (in- and outpatient) on immune cell recovery in patients undergoing an
      autologous stem cell transplantation. The secondary objective is to determine if 
      an exercise intervention diminishes the usual deterioration in quality of life,
      physical fitness, and the acquisition of a sedentary lifestyle. METHODS: This RCT
      has received approval from The Conjoint Health Research Ethics Board (CHREB) of
      the University of Calgary (Ethics ID # E-24476). Twenty-four participants treated
      for a malignancy with autologous stem cell transplant (5 to 18 years) in the
      Alberta Children's Hospital will be randomly assigned to an exercise or control
      group. The exercise group will participate in a two-phase exercise intervention
      (in- and outpatient) from hospitalization until 10 weeks after discharge. The
      exercise program includes strength, flexibility and aerobic exercise. During the 
      inpatient phase this program will be performed 5 times/week and will be
      supervised. The outpatient phase will combine a supervised session with two
      home-based exercise sessions with the use of the Wii device. The control group
      will follow the standard protocol without any specific exercise program. A range 
      of outcomes, including quantitative and functional recovery of immune system,
      cytokine levels in serum, natural killer (NK) cells and their subset recovery and
      function, and gene expression of activating and inhibitory NK cell receptors,
      body composition, nutrition, quality of life, fatigue, health-related fitness
      assessment and physical activity levels will be examined, providing the most
      comprehensive assessment to date. DISCUSSION: We expect to find improvements in
      immunological recovery and quality of life, and decreased acquisition of
      sedentary behavior and fitness deconditioning. The comprehensive outcomes
      generated in this RCT will provide preliminary data to conduct a multisite study 
      that will generate stronger outcomes. TRIAL REGISTRATION: Gov identification #
      NCT01666015.
FAU - Chamorro-Vina, Carolina
AU  - Chamorro-Vina C
AD  - Faculty of Kinesiology, University of Calgary, AB, Canada.
FAU - Guilcher, Gregory M T
AU  - Guilcher GM
FAU - Khan, Faisal M
AU  - Khan FM
FAU - Mazil, Karen
AU  - Mazil K
FAU - Schulte, Fiona
AU  - Schulte F
FAU - Wurz, Amanda
AU  - Wurz A
FAU - Williamson, Tanya
AU  - Williamson T
FAU - Reimer, Raylene A
AU  - Reimer RA
FAU - Culos-Reed, S Nicole
AU  - Culos-Reed SN
LA  - eng
SI  - ClinicalTrials.gov/NCT01666015
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20120910
PL  - England
TA  - BMC Cancer
JT  - BMC cancer
JID - 100967800
RN  - 0 (Cytokines)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Cytokines/blood
MH  - Exercise/*physiology
MH  - Hematopoietic Stem Cell Transplantation/*methods
MH  - Humans
MH  - Leukocyte Count
MH  - Neoplasms/blood/*rehabilitation/*surgery
MH  - Quality of Life
MH  - Randomized Controlled Trials as Topic
MH  - Software Design
MH  - Treatment Outcome
PMC - PMC3503655
EDAT- 2012/09/12 06:00
MHDA- 2013/07/16 06:00
CRDT- 2012/09/12 06:00
PHST- 2012/08/27 00:00 [received]
PHST- 2012/08/28 00:00 [accepted]
PHST- 2012/09/12 06:00 [entrez]
PHST- 2012/09/12 06:00 [pubmed]
PHST- 2013/07/16 06:00 [medline]
AID - 1471-2407-12-401 [pii]
AID - 10.1186/1471-2407-12-401 [doi]
PST - epublish
SO  - BMC Cancer. 2012 Sep 10;12:401. doi: 10.1186/1471-2407-12-401.


PMID- 22963293
OWN - NLM
STAT- MEDLINE
DCOM- 20121025
LR  - 20120911
IS  - 0970-258X (Print)
IS  - 0970-258X (Linking)
VI  - 25
IP  - 3
DP  - 2012 May-Jun
TI  - Reuse of single-use devices: looking back, looking forward.
PG  - 151-5
AB  - The reuse of medical devices marked as 'single use' by manufacturers has been
      going on for several decades. The process has been rationalized and legislated in
      the West as well as in Japan. However, the practice continues in an unregulated
      manner in India due to a paucity of guidance from the Food and Drug
      Administration in India. We trace the evolution of reuse policies, look at the
      prevalent practices in the Indian and international contexts, analyse the
      available Indian literature and address the ethical and economic implications of 
      reuse. We also suggest some guidelines which may be adopted to formulate
      policies.
CI  - Copyright 2012, NMJI.
FAU - Hussain, M
AU  - Hussain M
AD  - Department of Gastrointestinal and Laparoscopic Surgery, Bhatia Hospital, Mumbai,
      Maharashtra, India. maharrahussain@gmail.com
FAU - Balsara, K P
AU  - Balsara KP
FAU - Nagral, S
AU  - Nagral S
LA  - eng
PT  - Journal Article
PT  - Review
PL  - India
TA  - Natl Med J India
JT  - The National medical journal of India
JID - 8809315
SB  - IM
MH  - Cost Savings
MH  - Equipment Reuse/economics/standards/*statistics & numerical data
MH  - Equipment and Supplies/economics/standards/*statistics & numerical data
MH  - Humans
MH  - India
MH  - Sterilization/economics/standards/*statistics & numerical data
EDAT- 2012/09/12 06:00
MHDA- 2012/10/26 06:00
CRDT- 2012/09/12 06:00
PHST- 2012/09/12 06:00 [entrez]
PHST- 2012/09/12 06:00 [pubmed]
PHST- 2012/10/26 06:00 [medline]
PST - ppublish
SO  - Natl Med J India. 2012 May-Jun;25(3):151-5.


PMID- 22963218
OWN - NLM
STAT- MEDLINE
DCOM- 20121101
LR  - 20181201
IS  - 1441-2772 (Print)
IS  - 1441-2772 (Linking)
VI  - 14
IP  - 3
DP  - 2012 Sep
TI  - Uptake and caseload of intensive care unit liaison nurse services in Australia.
PG  - 221-6
AB  - BACKGROUND: Intensive care unit liaison nurses (ICULNs) represent a new clinical 
      service role in the Australian health care system. These nurses aim to improve
      patient outcomes by providing a specialised support service to ward staff caring 
      for acutely ill patients. As this role is relatively new, it is not known how
      many hospitals employ ICULNs or what the demand for their services is.
      OBJECTIVES: We aimed to identify the number of hospitals in the Australian
      College of Critical Care Nurses ICULN special interest group that report having
      an ICULN service, to document the timing of their introduction, and to assess
      changes in caseload since introduction. DESIGN AND SETTING: We conducted a
      retrospective observational study of the changes in ICULN operating hours and
      monthly patient reviews, and the timing of implementation of the services in
      Australian hospitals. We also assessed aspects of the ethics submission and
      approval process. RESULTS: Seventeen Australian hospitals submitted data. Before 
      2004, there were only two ICULN services. The number of services dramatically
      increased between 2004 and 2007. In 14 sites, monthly patient reviews increased
      by a median of 54.3%. After adjustment for staff hours, 10 hospitals reported an 
      increase in monthly patient reviews (median increase, 48.8%). Between 1999 and
      2011, the 17 services performed 123 236 patient reviews, including 73 022 ICU
      discharges (59.3%), 26 800 during or after rapid response team review (21.7%),
      and 23 414 de-novo referrals from ward staff (19.0%). CONCLUSION: The demand for 
      ICULN services has increased in most hospitals since the role was adopted,
      although this varies considerably. The majority of patients are reviewed after
      ICU discharge. Further research is needed to define the scope of practice of the 
      role and its impact on patient outcome, particularly in patients after ICU
      discharge.
CN  - Australian ICU Liaison Nurse Forum
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Crit Care Resusc
JT  - Critical care and resuscitation : journal of the Australasian Academy of Critical
      Care Medicine
JID - 100888170
SB  - IM
MH  - Australia
MH  - Humans
MH  - Intensive Care Units/*organization & administration
MH  - *Nursing, Supervisory/organization & administration/statistics & numerical data
MH  - Retrospective Studies
MH  - Workforce
IR  - Green A
FIR - Green, Anna
IR  - McIntyre T
FIR - McIntyre, Tammie
IR  - Taylor C
FIR - Taylor, Carmel
IR  - Chaboyer W
FIR - Chaboyer, Wendy
IR  - Jones D
FIR - Jones, Daryl
IR  - Elliot M
FIR - Elliot, Malcolm
IR  - Evans S
FIR - Evans, Sally
IR  - Jasiowski S
FIR - Jasiowski, Sofia
IR  - Day J
FIR - Day, Jane
IR  - McLeod M
FIR - McLeod, Marie
IR  - McCuskey K
FIR - McCuskey, Kelly
IR  - Dyer S
FIR - Dyer, Sarah
IR  - Doric A
FIR - Doric, Andrea
IR  - Summers T
FIR - Summers, Tanya
IR  - Haines J
FIR - Haines, Jackie
IR  - Carpen H
FIR - Carpen, Hailey
IR  - Molloy J
FIR - Molloy, Joanne
IR  - Pratt N
FIR - Pratt, Naomi
IR  - Murphy C
FIR - Murphy, Christine
IR  - Brown C
FIR - Brown, Christine
IR  - Tracey R
FIR - Tracey, Rebecca
IR  - Grant C
FIR - Grant, Chelsea
IR  - Kicker K
FIR - Kicker, Karen
IR  - Carbery C
FIR - Carbery, Catherine
IR  - Green A
FIR - Green, Anna
IR  - Lumsden J
FIR - Lumsden, Jenny
IR  - Tondello M
FIR - Tondello, Mark
IR  - Collins L
FIR - Collins, Lisa
IR  - Watts M
FIR - Watts, Michael
IR  - Hill F
FIR - Hill, Francisco
IR  - Hicks G
FIR - Hicks, Geoff
IR  - Morrissey K
FIR - Morrissey, Kylie
EDAT- 2012/09/12 06:00
MHDA- 2012/11/02 06:00
CRDT- 2012/09/12 06:00
PHST- 2012/09/12 06:00 [entrez]
PHST- 2012/09/12 06:00 [pubmed]
PHST- 2012/11/02 06:00 [medline]
PST - ppublish
SO  - Crit Care Resusc. 2012 Sep;14(3):221-6.


PMID- 22962701
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121017
LR  - 20211021
IS  - 1476-4687 (Electronic)
IS  - 0028-0836 (Linking)
VI  - 489
IP  - 7414
DP  - 2012 Sep 6
TI  - Electro-optic dye triggers ethics row.
PG  - 17
FAU - Reich, Eugenie Samuel
AU  - Reich ES
LA  - eng
PT  - News
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
EDAT- 2012/09/11 06:00
MHDA- 2012/09/11 06:01
CRDT- 2012/09/11 06:00
PHST- 2012/09/11 06:00 [entrez]
PHST- 2012/09/11 06:00 [pubmed]
PHST- 2012/09/11 06:01 [medline]
AID - 10.1038/489017a [doi]
PST - ppublish
SO  - Nature. 2012 Sep 6;489(7414):17. doi: 10.1038/489017a.


PMID- 22962599
OWN - NLM
STAT- MEDLINE
DCOM- 20130122
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 9
DP  - 2012
TI  - Institutional review boards' use and understanding of certificates of
      confidentiality.
PG  - e44050
LID - 10.1371/journal.pone.0044050 [doi]
AB  - Certificates of Confidentiality, issued by agencies of the U.S. government, are
      regarded as an important tool for meeting ethical and legal obligations to
      safeguard research participants' privacy and confidentiality. By shielding
      against forced disclosure of identifying data, Certificates are intended to
      facilitate research on sensitive topics critical to the public's health. Although
      Certificates are potentially applicable to an extensive array of research, their 
      full legal effect is unclear, and little is known about stakeholders' views of
      the protections they provide. To begin addressing this challenge, we conducted a 
      national survey of institutional review board (IRB) chairs, followed by telephone
      interviews with selected chairs, to learn more about their familiarity with and
      opinions about Certificates; their institutions' use of Certificates; policies
      and practices concerning when Certificates are required or recommended; and the
      role Certificates play in assessments of research risk. Overall, our results
      suggest uncertainty about Certificates among IRB chairs. On most objective
      knowledge questions, most respondents chose the incorrect answer or 'unsure'.
      Among chairs who reported more familiarity with Certificates, composite opinion
      scores calculated based on five survey questions were evenly distributed among
      positive, neutral/middle, and negative views. Further, respondents expressed a
      variety of ideas about the appropriate use of Certificates, what they are
      intended to protect, and their effect on research risk. Nevertheless, chairs who 
      participated in our study commonly viewed Certificates as a potentially valuable 
      tool, frequently describing them as an 'extra layer' of protection. These
      findings lead to several practical observations concerning the need for more
      stakeholder education about Certificates, consideration of Certificates for a
      broader range of studies, the importance of remaining vigilant and using all
      tools available to protect participants' confidentiality, and the need for
      further empirical investigation of Certificates' effect on researchers and
      research participants.
FAU - Beskow, Laura M
AU  - Beskow LM
AD  - Institute for Genome Sciences and Policy, Duke University, Durham, North
      Carolina, United States of America.
FAU - Check, Devon K
AU  - Check DK
FAU - Namey, Emily E
AU  - Namey EE
FAU - Dame, Lauren A
AU  - Dame LA
FAU - Lin, Li
AU  - Lin L
FAU - Cooper, Alexandra
AU  - Cooper A
FAU - Weinfurt, Kevin P
AU  - Weinfurt KP
FAU - Wolf, Leslie E
AU  - Wolf LE
LA  - eng
GR  - R01 HG005087/HG/NHGRI NIH HHS/United States
GR  - R01HG005087/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120904
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Confidentiality/*ethics/psychology
MH  - Data Collection
MH  - Disclosure
MH  - *Ethics Committees, Research
MH  - Ethics, Research
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Privacy
MH  - Research
MH  - Research Personnel/*ethics/psychology
MH  - United States
PMC - PMC3433491
EDAT- 2012/09/11 06:00
MHDA- 2013/01/23 06:00
CRDT- 2012/09/11 06:00
PHST- 2012/05/21 00:00 [received]
PHST- 2012/07/27 00:00 [accepted]
PHST- 2012/09/11 06:00 [entrez]
PHST- 2012/09/11 06:00 [pubmed]
PHST- 2013/01/23 06:00 [medline]
AID - 10.1371/journal.pone.0044050 [doi]
AID - PONE-D-12-15979 [pii]
PST - ppublish
SO  - PLoS One. 2012;7(9):e44050. doi: 10.1371/journal.pone.0044050. Epub 2012 Sep 4.


PMID- 22962584
OWN - NLM
STAT- MEDLINE
DCOM- 20130122
LR  - 20211203
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 9
DP  - 2012
TI  - Ontological differences in first compared to third trimester human fetal
      placental chorionic stem cells.
PG  - e43395
LID - 10.1371/journal.pone.0043395 [doi]
AB  - Human mesenchymal stromal/stem cells (MSC) isolated from fetal tissues hold
      promise for use in tissue engineering applications and cell-based therapies, but 
      their collection is restricted ethically and technically. In contrast, the
      placenta is a potential source of readily-obtainable stem cells throughout
      pregnancy. In fetal tissues, early gestational stem cells are known to have
      advantageous characteristics over neonatal and adult stem cells. Accordingly, we 
      investigated whether early fetal placental chorionic stem cells (e-CSC) were
      physiologically superior to their late gestation fetal chorionic counterparts
      (l-CSC). We showed that e-CSC shared a common phenotype with l-CSC,
      differentiating down the osteogenic, adipogenic and neurogenic pathways, and
      containing a subset of cells endogenously expressing NANOG, SOX2, c-MYC, and
      KLF4, as well as an array of genes expressed in pluripotent stem cells and
      primordial germ cells, including CD24, NANOG, SSEA4, SSEA3, TRA-1-60, TRA-1-81,
      STELLA, FRAGILIS, NANOS3, DAZL and SSEA1. However, we showed that e-CSC have
      characteristics of an earlier state of stemness compared to l-CSC, such as
      smaller size, faster kinetics, uniquely expressing OCT4A variant 1 and showing
      higher levels of expression of NANOG, SOX2, c-MYC and KLF4 than l-CSC.
      Furthermore e-CSC, but not l-CSC, formed embryoid bodies containing cells from
      the three germ layer lineages. Finally, we showed that e-CSC demonstrate higher
      tissue repair in vivo; when transplanted in the osteogenesis imperfecta mice,
      e-CSC, but not l-CSC increased bone quality and plasticity; and when applied to a
      skin wound, e-CSC, but not l-CSC, accelerated healing compared to controls. Our
      results provide insight into the ontogeny of the stemness phenotype during fetal 
      development and suggest that the more primitive characteristics of early compared
      to late gestation fetal chorionic stem cells may be translationally advantageous.
FAU - Jones, Gemma N
AU  - Jones GN
AD  - Institute of Reproductive and Developmental Biology, Imperial College London,
      London, United Kingdom.
FAU - Moschidou, Dafni
AU  - Moschidou D
FAU - Puga-Iglesias, Tamara-Isabel
AU  - Puga-Iglesias TI
FAU - Kuleszewicz, Katarzyna
AU  - Kuleszewicz K
FAU - Vanleene, Maximilien
AU  - Vanleene M
FAU - Shefelbine, Sandra J
AU  - Shefelbine SJ
FAU - Bou-Gharios, George
AU  - Bou-Gharios G
FAU - Fisk, Nicholas M
AU  - Fisk NM
FAU - David, Anna L
AU  - David AL
FAU - De Coppi, Paolo
AU  - De Coppi P
FAU - Guillot, Pascale V
AU  - Guillot PV
LA  - eng
GR  - Biotechnology and Biological Sciences Research Council/United Kingdom
GR  - Department of Health/United Kingdom
GR  - Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120904
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Biomarkers)
RN  - 0 (KLF4 protein, human)
RN  - 0 (Klf4 protein, mouse)
RN  - 0 (Kruppel-Like Factor 4)
RN  - 0 (Stage-Specific Embryonic Antigens)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Cell Differentiation
MH  - Chorion/*cytology/metabolism
MH  - Female
MH  - Fetal Stem Cells/*cytology/metabolism/transplantation
MH  - Humans
MH  - Kruppel-Like Factor 4
MH  - Mesenchymal Stem Cells/*cytology/metabolism
MH  - Mice
MH  - Mice, Transgenic
MH  - Placenta/*cytology/metabolism
MH  - Pluripotent Stem Cells/cytology/metabolism
MH  - Pregnancy
MH  - Pregnancy Trimester, First
MH  - Pregnancy Trimester, Third
MH  - Skin/injuries
MH  - Stage-Specific Embryonic Antigens/genetics/*metabolism
MH  - Stem Cell Transplantation
MH  - Time Factors
MH  - Transplantation, Heterologous
MH  - Wound Healing
PMC - PMC3433473
EDAT- 2012/09/11 06:00
MHDA- 2013/01/23 06:00
CRDT- 2012/09/11 06:00
PHST- 2012/03/19 00:00 [received]
PHST- 2012/07/19 00:00 [accepted]
PHST- 2012/09/11 06:00 [entrez]
PHST- 2012/09/11 06:00 [pubmed]
PHST- 2013/01/23 06:00 [medline]
AID - 10.1371/journal.pone.0043395 [doi]
AID - PONE-D-12-08022 [pii]
PST - ppublish
SO  - PLoS One. 2012;7(9):e43395. doi: 10.1371/journal.pone.0043395. Epub 2012 Sep 4.


PMID- 22962030
OWN - NLM
STAT- MEDLINE
DCOM- 20140626
LR  - 20141113
IS  - 1099-0879 (Electronic)
IS  - 1063-3995 (Linking)
VI  - 21
IP  - 1
DP  - 2014 Jan-Feb
TI  - Treatment response in type 2 diabetes patients with major depression.
PG  - 39-48
LID - 10.1002/cpp.1817 [doi]
AB  - AIMS: Major depression is more prevalent in patients with type 2 diabetes
      mellitus (T2DM) than in general population. Comparing psychotherapeutic and
      pharmacological treatment responses could help to inform the choice between
      available treatment options. METHOD: Thirty-four patients with T2DM and major
      depression detected by using the Hospital Anxiety-Depression Scale (HADS), the
      Montgomery-Asberg Depression Rating Scale (MADRS) and a structured interview
      (Mini-International Neuropsychiatric Interview) were randomized to undergo
      Interpersonal Psychotherapy (IPT) or treatment with sertraline in a 3-month acute
      intervention course in addition to a 3-month continuation format. Provided that
      the initial MADRS score was not reduced >/=25% at week 6, these early
      non-responding patients continued treatment in a sequential add-on combined
      format. Psychological adjustment to diabetes, attachment style, diabetes
      self-efficacy, quality of life and HbA1c were also evaluated along intervention. 
      RESULTS: Out of 22 early-responding patients (11 for each treatment type), 16 had
      clinically significant improvements (<50% initial MADRS score) at endpoint with
      11 reaching remission (MADRS scores </=8), and with no significant differences
      between IPT and sertraline. Within sequential add-on treatment, out of eight
      patients, only three of them achieved a clinically significant improvement and
      only one reached remission. CONCLUSIONS: These preliminary results suggested that
      IPT may be an option to treat major depression in T2DM against medical care with 
      sertraline. Early non-responding patients likely need alternative or longer
      treatment interventions. Limitations of this study relate to small sample and
      absence of a control group, which was difficult to implement due to ethical
      restrictions. KEY PRACTITIONER MESSAGE: Findings suggest that Interpersonal
      Psychotherapy is a useful tool to treat major depression in type 2 diabetes
      patients. A significant number of type 2 diabetes patients with major depression 
      do not achieve depression remission irrespective of the type of treatment.
      Further clinical research should focus on addictive effects of psychotherapy and 
      psychopharmacology in the treatment of depressed patients with chronic somatic
      diseases.
CI  - Copyright (c) 2012 John Wiley & Sons, Ltd.
FAU - Gois, C
AU  - Gois C
AD  - Department of Psychiatry, Faculty of Medicine, University of Lisbon, Santa Maria 
      Hospital, Lisbon, Portugal.
FAU - Dias, V V
AU  - Dias VV
FAU - Carmo, I
AU  - Carmo I
FAU - Duarte, R
AU  - Duarte R
FAU - Ferro, A
AU  - Ferro A
FAU - Santos, A L
AU  - Santos AL
FAU - Sousa, F
AU  - Sousa F
FAU - Barbosa, A
AU  - Barbosa A
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20120910
PL  - England
TA  - Clin Psychol Psychother
JT  - Clinical psychology & psychotherapy
JID - 9416196
RN  - 0 (Antidepressive Agents)
RN  - QUC7NX6WMB (Sertraline)
SB  - IM
MH  - Analysis of Variance
MH  - Antidepressive Agents/*therapeutic use
MH  - Depressive Disorder, Major/*complications/drug therapy/*therapy
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Psychotherapy/*methods
MH  - Quality of Life/psychology
MH  - Sertraline/*therapeutic use
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Depression
OT  - Diabetes
OT  - Interpersonal Psychotherapy
EDAT- 2012/09/11 06:00
MHDA- 2014/06/27 06:00
CRDT- 2012/09/11 06:00
PHST- 2011/11/13 00:00 [received]
PHST- 2012/07/21 00:00 [revised]
PHST- 2012/07/30 00:00 [accepted]
PHST- 2012/09/11 06:00 [entrez]
PHST- 2012/09/11 06:00 [pubmed]
PHST- 2014/06/27 06:00 [medline]
AID - 10.1002/cpp.1817 [doi]
PST - ppublish
SO  - Clin Psychol Psychother. 2014 Jan-Feb;21(1):39-48. doi: 10.1002/cpp.1817. Epub
      2012 Sep 10.


PMID- 22961613
OWN - NLM
STAT- MEDLINE
DCOM- 20130308
LR  - 20211021
IS  - 1432-1009 (Electronic)
IS  - 0364-152X (Linking)
VI  - 50
IP  - 5
DP  - 2012 Nov
TI  - Significance of perceived social expectation and implications to conservation
      education: turtle conservation as a case study.
PG  - 900-13
LID - 10.1007/s00267-012-9926-2 [doi]
AB  - The likelihood of participating in wildlife conservation programs is dependent on
      social influences and circumstances. This view is validated by a case study of
      behavioral intention to support conservation of Asian turtles. A total of 776
      college students in China completed a questionnaire survey designed to identify
      factors associated with their intention to support conservation. A regression
      model explained 48 % of variance in the level of intention. Perceived social
      expectation was the strongest predictor, followed by attitudes toward turtle
      protection and perceived behavioral control, altogether explaining 44 %. Strong
      ethics and socio-economic variables had some statistical significant impacts and 
      accounted for 3 % of the variance. The effects of general environmental
      awareness, trust and responsibility ascription were modest. Knowledge about
      turtles was a weak predictor. We conclude that perceived social expectation is a 
      limiting factor of conservation behavior. Sustained interest and commitment to
      conservation can be created by enhancing positive social influences. Conservation
      educators should explore the potential of professionally supported, group-based
      actions that can nurture a sense of collective achievement as part of an
      educational campaign.
FAU - Lo, Alex Y
AU  - Lo AY
AD  - Griffith School of Environment, Griffith University, Gold Coast, QLD 4222,
      Australia. alex.lo@griffith.edu.au
FAU - Chow, Alex T
AU  - Chow AT
FAU - Cheung, Sze Man
AU  - Cheung SM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120909
PL  - United States
TA  - Environ Manage
JT  - Environmental management
JID - 7703893
SB  - IM
MH  - Adult
MH  - Animals
MH  - China
MH  - *Conservation of Natural Resources
MH  - Female
MH  - Humans
MH  - Male
MH  - Social Behavior
MH  - Surveys and Questionnaires
MH  - *Turtles
MH  - Young Adult
EDAT- 2012/09/11 06:00
MHDA- 2013/03/09 06:00
CRDT- 2012/09/11 06:00
PHST- 2011/09/16 00:00 [received]
PHST- 2012/07/23 00:00 [accepted]
PHST- 2012/09/11 06:00 [entrez]
PHST- 2012/09/11 06:00 [pubmed]
PHST- 2013/03/09 06:00 [medline]
AID - 10.1007/s00267-012-9926-2 [doi]
PST - ppublish
SO  - Environ Manage. 2012 Nov;50(5):900-13. doi: 10.1007/s00267-012-9926-2. Epub 2012 
      Sep 9.


PMID- 22961360
OWN - NLM
STAT- MEDLINE
DCOM- 20131017
LR  - 20211021
IS  - 1433-0350 (Electronic)
IS  - 0256-7040 (Linking)
VI  - 29
IP  - 2
DP  - 2013 Feb
TI  - Severe spinal cord injury in craniocervical dislocation. Case-based update.
PG  - 187-94
LID - 10.1007/s00381-012-1915-5 [doi]
AB  - BACKGROUND: Craniocervical distraction injuries, including atlanto-axial
      dislocation (AAD) and atlanto-ocipital dislocation (AOD), are often associated
      with severe spinal cord involvement with high morbidity and mortality rates. Many
      patients with these injuries die at the accident scene, but advances in emergency
      resuscitation and transport permit that many patients arrive alive to hospitals. 
      DISCUSSION: Children with craniocervical distraction injuries usually present
      with a severe cranioencephalic traumatism that is the most relevant lesion at
      admission. After resuscitation and hemodynamic stabilization, the spinal cord
      damage appears as the main lesion. Apnea and quadriparesis, or quadriplegia, are 
      usually present at the onset. Early diagnosis and management perhaps decrease
      life-threatening manifestations of the spinal lesion. But even so, the primary
      spinal cord insult is often irreversible and precludes obtaining a satisfactory
      functional outcome. PATIENTS AND METHODS: We report the findings of four children
      with craniocervical distraction injuries (AOD and AAD) who presented with severe 
      spinal cord damage. All patients were admitted with respiratory distress or apnea
      together with significant brain injuries. The medical records pertaining to these
      patients are summarized in regard to clinical features, management, and outcome. 
      CONCLUSIONS: In spite of timely and aggressive management, craniocervical
      injuries with spinal cord involvement continue to have a dismal prognosis.
      Outcome is closely related to the severity of the initial brain and spinal cord
      damage and is nearly always fatal in cases of complete spinal cord transection.
      Priority should be given to life-threatening complications. Ethic issues on
      indications for surgery deserve a detailed discussion with the children's
      parents.
FAU - Martinez-Lage, Juan F
AU  - Martinez-Lage JF
AD  - Unit of Pediatric Neurosurgery, Regional Service of Neurosurgery, Virgen de la
      Arrixaca University Children's Hospital, 30120 El Palmar, Murcia, Spain.
      juanf.martinezlage@cablemurcia.com
FAU - Alarcon, Fernando
AU  - Alarcon F
FAU - Alfaro, Raul
AU  - Alfaro R
FAU - Gilabert, Amparo
AU  - Gilabert A
FAU - Reyes, Susana B
AU  - Reyes SB
FAU - Almagro, Maria-Jose
AU  - Almagro MJ
FAU - Lopez Lopez-Guerrero, Antonio
AU  - Lopez Lopez-Guerrero A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20120908
PL  - Germany
TA  - Childs Nerv Syst
JT  - Child's nervous system : ChNS : official journal of the International Society for
      Pediatric Neurosurgery
JID - 8503227
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Infant
MH  - Joint Dislocations/complications/*diagnosis
MH  - Male
MH  - *Severity of Illness Index
MH  - Spinal Cord Injuries/complications/*diagnosis
MH  - Trauma, Nervous System/complications/*diagnosis
EDAT- 2012/09/11 06:00
MHDA- 2013/10/18 06:00
CRDT- 2012/09/11 06:00
PHST- 2012/02/22 00:00 [received]
PHST- 2012/08/27 00:00 [accepted]
PHST- 2012/09/11 06:00 [entrez]
PHST- 2012/09/11 06:00 [pubmed]
PHST- 2013/10/18 06:00 [medline]
AID - 10.1007/s00381-012-1915-5 [doi]
PST - ppublish
SO  - Childs Nerv Syst. 2013 Feb;29(2):187-94. doi: 10.1007/s00381-012-1915-5. Epub
      2012 Sep 8.


PMID- 22961283
OWN - NLM
STAT- MEDLINE
DCOM- 20121016
LR  - 20181201
IS  - 0303-7339 (Print)
IS  - 0303-7339 (Linking)
VI  - 54
IP  - 9
DP  - 2012
TI  - [Reaction on 'the ethical duty to treat children and adolescents with autism and 
      catatonia'].
PG  - 843-4; author reply 844
FAU - Sizoo, Bram
AU  - Sizoo B
FAU - van der Reijden, Matt
AU  - van der Reijden M
LA  - dut
PT  - Letter
PT  - Comment
TT  - Reactie op 'Behandeling van jongeren met autisme en katatonie: ethische plicht'
PL  - Netherlands
TA  - Tijdschr Psychiatr
JT  - Tijdschrift voor psychiatrie
JID - 0423731
SB  - IM
CON - Tijdschr Psychiatr. 2012;54(6):493-5. PMID: 22753181
MH  - Autistic Disorder/*therapy
MH  - Catatonia/*therapy
MH  - Child Psychiatry/*ethics
MH  - *Ethics, Clinical
MH  - Humans
EDAT- 2012/09/11 06:00
MHDA- 2012/10/17 06:00
CRDT- 2012/09/11 06:00
PHST- 2012/09/11 06:00 [entrez]
PHST- 2012/09/11 06:00 [pubmed]
PHST- 2012/10/17 06:00 [medline]
AID - TVPart_9582 [pii]
PST - ppublish
SO  - Tijdschr Psychiatr. 2012;54(9):843-4; author reply 844.


PMID- 22961004
OWN - NLM
STAT- MEDLINE
DCOM- 20140401
LR  - 20211021
IS  - 2193-6226 (Electronic)
IS  - 2193-6218 (Linking)
VI  - 108
IP  - 4
DP  - 2013 May
TI  - [Enrolment of intensive care patients in clinical studies. Ethical, legal and
      organizational problems from an interdisciplinary point of view].
PG  - 303-10
LID - 10.1007/s00063-012-0153-7 [doi]
AB  - Nowadays, most patients in hospital die in the intensive care unit from sepsis
      and multiple organ failure. Clinical research in this critically ill and
      vulnerable patient population bears a lot of ethical and legal problems; however,
      it remains a must in order to develop evidence-based diagnostic and therapeutic
      strategies for life-threatening diseases with special respect to limited health
      care resources. With regard to the Declaration of Helsinki, good clinical
      practice guidelines (GCP) from the European Medicines Agency (EMA) and the German
      medical drug law (AMG) this article discusses ethical and legal aspects of
      patient inclusion for clinical trials as well as incentives for appropriate
      patient recruitment from an interdisciplinary point of view.
FAU - Weimann, A
AU  - Weimann A
AD  - Klinik fur Allgemein- und Visceralchirurgie, Klinikum St. Georg gGmbH,
      Delitzscher Str. 141, 04129, Leipzig. arved.weimann@sanktgeorg.de
FAU - Kern, B R
AU  - Kern BR
FAU - Loffler, M
AU  - Loffler M
FAU - Sablotzki, A
AU  - Sablotzki A
FAU - Thiele, F
AU  - Thiele F
FAU - Brunkhorst, F M
AU  - Brunkhorst FM
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Der Einschluss von Intensivpatienten in klinische Studien. Ethische, rechtliche
      und organisatorische Probleme aus interdisziplinarer Sicht.
DEP - 20120909
PL  - Germany
TA  - Med Klin Intensivmed Notfmed
JT  - Medizinische Klinik, Intensivmedizin und Notfallmedizin
JID - 101575086
SB  - IM
MH  - *Cooperative Behavior
MH  - Critical Care/*ethics/*legislation & jurisprudence/organization & administration
MH  - *Ethics, Research
MH  - Evidence-Based Medicine
MH  - Germany
MH  - Guideline Adherence
MH  - Helsinki Declaration
MH  - Humans
MH  - *Interdisciplinary Communication
MH  - Multiple Organ Failure/mortality/*therapy
MH  - Patient Selection/*ethics
MH  - Prognosis
MH  - Randomized Controlled Trials as Topic/*ethics/*legislation & jurisprudence
MH  - Sepsis/mortality/*therapy
EDAT- 2012/09/11 06:00
MHDA- 2014/04/02 06:00
CRDT- 2012/09/11 06:00
PHST- 2012/05/10 00:00 [received]
PHST- 2012/08/07 00:00 [accepted]
PHST- 2012/07/04 00:00 [revised]
PHST- 2012/09/11 06:00 [entrez]
PHST- 2012/09/11 06:00 [pubmed]
PHST- 2014/04/02 06:00 [medline]
AID - 10.1007/s00063-012-0153-7 [doi]
PST - ppublish
SO  - Med Klin Intensivmed Notfmed. 2013 May;108(4):303-10. doi:
      10.1007/s00063-012-0153-7. Epub 2012 Sep 9.


PMID- 22960962
OWN - NLM
STAT- MEDLINE
DCOM- 20121127
LR  - 20161125
IS  - 1119-3077 (Print)
VI  - 15
IP  - 3
DP  - 2012 Jul-Sep
TI  - Comparative ultrasound measurement of normal thyroid gland dimensions in school
      aged children in our local environment.
PG  - 285-92
LID - 10.4103/1119-3077.100622 [doi]
AB  - OBJECTIVE: The objective of this study was to determine the measurement of normal
      range of ultrasound (US) thyroid gland dimensions in school-aged children (6-16
      years) in our environment and compared with what is obtained elsewhere. SETTING
      AND DESIGN: A prospective ultrasound measurement study done in University of
      Benin Teaching Hospital Benin, Nigeria. MATERIALS AND METHODS: A prospective
      ultrasound (US) study of thyroid dimensions of 500 school-aged children in our
      environment consisting of 227 boys and 273 girls was done from 1 December 2006 to
      July 2007. The subjects were examined by the authors and subjects with palpable
      abnormal thyroid gland were excluded from the study. The thyroid dimensions
      (length, height, and diameter) were taken for each lobe by means of ultrasound
      (US). In addition volume of each thyroid lobe was calculated and the summation of
      volume of the lobes was taken as thyroid gland volume of each subject. Also
      height and weight of patients were documented from which the subject's body
      surface was calculated. Incidental thyroid gland lesion in US was excluded from
      the study. Using the Statistical program of social science (SPSS) and INSTAT
      (Graph Pad Inc. USA) the data were analyzed. Informed consent was obtained from
      all the subjects and the study was done in line with the ethical guidelines of
      the centers. RESULTS: The US thyroid gland volume in school-aged children in
      Benin City from this study ranges between 1.17 cm 3 and 7.19 cm 3 , mean volume
      range of 1.76-4.95 cm 3 , median volume range of 1.73-4.73 cm 3 , and range of
      standard deviation from 0.39 cm 3 to 1.49 cm 3 . The average mean thyroid volume 
      is 2.32 cm 3 with the following average dimensions; anteroposterior right lobe
      =1.06 cm, mediolateral right lobe = 1.01 cm and craniocaudal right lobe = 2.34
      cm, and anteroposterior left lobe = 1.01 cm, mediolateral left lobe = 1.04 cm and
      craniocaudal left lobe = 2.41 cm for both boys and girls respectively. These data
      are significantly lower than data obtained by European based World Health
      Organization/International Council for the Control of Iodine Deficiency Disorders
      (WHO/ICCIDD) 1997. However there is significant similarity with data obtained in 
      similar environment. CONCLUSION: Ultrasound thyroid gland dimensions in
      school-aged children in our environment are reproducible and the data obtained
      are comparable to those obtained in other environment. The values may be better
      used in our environment as reference data for screening purposes.
FAU - Marchie, T T
AU  - Marchie TT
AD  - Department of Radiology, University of Benin Teaching Hospital Benin - City,
      Nigeria. tmarchie2000@yahoo.com
FAU - Oyobere, O
AU  - Oyobere O
FAU - Eze, K C
AU  - Eze KC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - India
TA  - Niger J Clin Pract
JT  - Nigerian journal of clinical practice
JID - 101150032
SB  - IM
MH  - Adolescent
MH  - Body Surface Area
MH  - Child
MH  - Female
MH  - Humans
MH  - Male
MH  - Organ Size
MH  - Reference Values
MH  - Thyroid Gland/*anatomy & histology/*diagnostic imaging
MH  - Ultrasonography
EDAT- 2012/09/11 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/09/11 06:00
PHST- 2012/09/11 06:00 [entrez]
PHST- 2012/09/11 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - NigerJClinPract_2012_15_3_285_100622 [pii]
AID - 10.4103/1119-3077.100622 [doi]
PST - ppublish
SO  - Niger J Clin Pract. 2012 Jul-Sep;15(3):285-92. doi: 10.4103/1119-3077.100622.


PMID- 22960919
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20191210
IS  - 1943-3662 (Electronic)
IS  - 1093-6793 (Linking)
VI  - 40
IP  - 3
DP  - 2012
TI  - A training program for defendants with intellectual disabilities who are found
      incompetent to stand trial.
PG  - 366-73
AB  - In this study, we examined whether a specialized training program, the Slater
      Method, affects rates at which persons with intellectual disabilities attain
      competence to stand trial. We reviewed records of all 30 persons with Diagnostic 
      and Statistical Manual of Mental Disorders (DSM-IV-TR) clinical diagnoses of
      mental retardation (in this article, intellectual disability) or borderline
      intellectual functioning whom courts sent to Eleanor Slater Hospital for
      competency restoration from 2001 through 2006. Significantly more persons exposed
      to the Slater Method attained clinical trial competence (61.1%) than did persons 
      who received traditional treatment alone (16.7%). Discussion focuses on potential
      limitations of the study, ethics-related concerns regarding use of the Slater
      Method, and directions for future research.
FAU - Wall, Barry W
AU  - Wall BW
AD  - Department of Psychiatry and Human Behavior, Warren Alpert Medical School of
      Brown University, Providence, RI, USA. bwall@bhddh.ri.gov
FAU - Christopher, Paul P
AU  - Christopher PP
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - United States
TA  - J Am Acad Psychiatry Law
JT  - The journal of the American Academy of Psychiatry and the Law
JID - 9708963
SB  - IM
MH  - Adult
MH  - *Education of Intellectually Disabled/methods
MH  - Female
MH  - Humans
MH  - *Intellectual Disability
MH  - Male
MH  - Medical Audit
MH  - Mental Competency/*legislation & jurisprudence
MH  - Middle Aged
MH  - Program Evaluation
MH  - Retrospective Studies
MH  - Rhode Island
MH  - Young Adult
EDAT- 2012/09/11 06:00
MHDA- 2013/02/13 06:00
CRDT- 2012/09/11 06:00
PHST- 2012/09/11 06:00 [entrez]
PHST- 2012/09/11 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
AID - 40/3/366 [pii]
PST - ppublish
SO  - J Am Acad Psychiatry Law. 2012;40(3):366-73.


PMID- 22960836
OWN - NLM
STAT- MEDLINE
DCOM- 20130322
LR  - 20131121
IS  - 0973-3922 (Electronic)
IS  - 0378-6323 (Linking)
VI  - 78
IP  - 5
DP  - 2012 Sep-Oct
TI  - Oxidative stress and leukocyte migration inhibition response in cutaneous adverse
      drug reactions.
PG  - 664
LID - 10.4103/0378-6323.100519 [doi]
AB  - BACKGROUND: Cutaneous adverse drug reactions (CADRs) may either be immunological 
      or non-immunological. The precise mechanisms, however, are largely obscure. Other
      concomitant mechanisms may amplify and/or contribute to the severity and duration
      of a reaction. One such mechanism could be oxidative stress, a state of imbalance
      between reactive oxygen species, and their subsequent detoxification by
      antioxidants. AIMS: (a) to assess the oxidative stress status in the blood of
      cutaneous drug reaction patients by assaying for reduced glutathione (GSH) and
      malondialdehyde (MDA) levels, (b) to determine the leukocyte migration inhibition
      (LMI) response in these patients in response to the suspected drug (s), and (c)
      to look for the association between oxidative stress parameters and LMI. METHODS:
      Ethical committee approval was obtained for this study. Fresh venous blood
      samples were obtained from the patients of CADRs (group A) during the acute phase
      of reaction and healthy control subjects (group B). MDA levels, a measure of
      oxidative lipid damage, and reduced GSH levels, a measure of anti-oxidant
      capacity, were assayed in the blood samples of both groups using
      spectrophotometry. LMI response was measured by challenging the patients'
      peripheral blood mononuclear cells with the suspected drug to confirm
      immunological perturbation. RESULTS: Totally 66 participants, 33 cases in group A
      and equal number of controls in group B, were studied. The mean MDA levels were
      found to be raised (P < 0.001), but GSH levels were significantly reduced in
      group A when compared with group B (P = <0.001). LMI response against drug(s) was
      performed in 33 cases (group A), out of which 25 cases showed a positive LMI
      response as follows: fixed drug eruption (10/25), SJS (5/25), urticaria (3/25),
      exfoliative dermatitis (2/25), morbilliform rash (2/25), erythroderma (1/25),
      vasculitis (1/25), and dapsone syndrome (1/25). The mean MDA levels were found to
      be significantly higher in the LMI positive CADRs (P < 0.001) when compared with 
      LMI-negative ones, while no significant difference was seen for GSH (P = 0.100). 
      Furthermore, there was a significant positive correlation between MDA levels and 
      LMI response (r = 0.831, P < 0.001). On the other hand, a negative but
      statistically insignificant correlation was found between GSH and LMI response (r
      = -0.248, P = 0.271). CONCLUSION: CADR patients were found to be under oxidative 
      stress based on MDA and GSH levels in the peripheral blood. There is a
      significant positive correlation of LMI response (against the causative drug)
      with MDA levels, which strongly associates oxidative stress with the
      immunopathogenesis in CADRs.
FAU - Verma, Prashant
AU  - Verma P
AD  - Department of Dermatology and STD, University College of Medical Sciences,
      University of Delhi, Delhi, India.
FAU - Bhattacharya, Sambit Nath
AU  - Bhattacharya SN
FAU - Banerjee, Basu Deb
AU  - Banerjee BD
FAU - Khanna, Naresh
AU  - Khanna N
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Indian J Dermatol Venereol Leprol
JT  - Indian journal of dermatology, venereology and leprology
JID - 7701852
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Case-Control Studies
MH  - Cell Migration Assays, Leukocyte
MH  - Cell Movement/*drug effects
MH  - Dermatitis, Exfoliative/blood/chemically induced/immunology
MH  - Drug Eruptions/*blood/*immunology
MH  - Female
MH  - Glutathione/blood
MH  - Humans
MH  - Leukocytes, Mononuclear/*drug effects
MH  - Male
MH  - Malondialdehyde/blood
MH  - *Oxidative Stress
MH  - Stevens-Johnson Syndrome/blood/chemically induced/immunology
MH  - Urticaria/blood/chemically induced/immunology
MH  - Vasculitis/blood/chemically induced/immunology
EDAT- 2012/09/11 06:00
MHDA- 2013/03/23 06:00
CRDT- 2012/09/11 06:00
PHST- 2012/09/11 06:00 [entrez]
PHST- 2012/09/11 06:00 [pubmed]
PHST- 2013/03/23 06:00 [medline]
AID - ijdvl_2012_78_5_664_100519 [pii]
AID - 10.4103/0378-6323.100519 [doi]
PST - ppublish
SO  - Indian J Dermatol Venereol Leprol. 2012 Sep-Oct;78(5):664. doi:
      10.4103/0378-6323.100519.


PMID- 22959699
OWN - NLM
STAT- MEDLINE
DCOM- 20130206
LR  - 20220311
IS  - 1552-5279 (Electronic)
IS  - 1552-5260 (Linking)
VI  - 8
IP  - 5
DP  - 2012 Sep
TI  - Advancing Alzheimer's disease diagnosis, treatment, and care: recommendations
      from the Ware Invitational Summit.
PG  - 445-52
LID - 10.1016/j.jalz.2012.08.001 [doi]
AB  - To address the pending public health crisis due to Alzheimer's disease (AD) and
      related neurodegenerative disorders, the Marian S. Ware Alzheimer Program at the 
      University of Pennsylvania held a meeting entitled "State of the Science
      Conference on the Advancement of Alzheimer's Diagnosis, Treatment and Care," on
      June 21-22, 2012. The meeting comprised four workgroups focusing on Biomarkers;
      Clinical Care and Health Services Research; Drug Development; and Health
      Economics, Policy, and Ethics. The workgroups shared, discussed, and compiled an 
      integrated set of priorities, recommendations, and action plans, which are
      presented in this article.
CI  - Copyright (c) 2012 The Alzheimer's Association. Published by Elsevier Inc. All
      rights reserved.
FAU - Naylor, Mary D
AU  - Naylor MD
AD  - Institute on Aging, University of Pennsylvania, Philadelphia, USA.
      naylor@nursing.upenn.edu
FAU - Karlawish, Jason H
AU  - Karlawish JH
FAU - Arnold, Steven E
AU  - Arnold SE
FAU - Khachaturian, Ara S
AU  - Khachaturian AS
FAU - Khachaturian, Zaven S
AU  - Khachaturian ZS
FAU - Lee, Virginia M-Y
AU  - Lee VM
FAU - Baumgart, Matthew
AU  - Baumgart M
FAU - Banerjee, Sube
AU  - Banerjee S
FAU - Beck, Cornelia
AU  - Beck C
FAU - Blennow, Kaj
AU  - Blennow K
FAU - Brookmeyer, Ron
AU  - Brookmeyer R
FAU - Brunden, Kurt R
AU  - Brunden KR
FAU - Buckwalter, Kathleen C
AU  - Buckwalter KC
FAU - Comer, Meryl
AU  - Comer M
FAU - Covinsky, Kenneth
AU  - Covinsky K
FAU - Feinberg, Lynn Friss
AU  - Feinberg LF
FAU - Frisoni, Giovanni
AU  - Frisoni G
FAU - Green, Colin
AU  - Green C
FAU - Guimaraes, Renato Maia
AU  - Guimaraes RM
FAU - Gwyther, Lisa P
AU  - Gwyther LP
FAU - Hefti, Franz F
AU  - Hefti FF
FAU - Hutton, Michael
AU  - Hutton M
FAU - Kawas, Claudia
AU  - Kawas C
FAU - Kent, David M
AU  - Kent DM
FAU - Kuller, Lewis
AU  - Kuller L
FAU - Langa, Kenneth M
AU  - Langa KM
FAU - Mahley, Robert W
AU  - Mahley RW
FAU - Maslow, Katie
AU  - Maslow K
FAU - Masters, Colin L
AU  - Masters CL
FAU - Meier, Diane E
AU  - Meier DE
FAU - Neumann, Peter J
AU  - Neumann PJ
FAU - Paul, Steven M
AU  - Paul SM
FAU - Petersen, Ronald C
AU  - Petersen RC
FAU - Sager, Mark A
AU  - Sager MA
FAU - Sano, Mary
AU  - Sano M
FAU - Schenk, Dale
AU  - Schenk D
FAU - Soares, Holly
AU  - Soares H
FAU - Sperling, Reisa A
AU  - Sperling RA
FAU - Stahl, Sidney M
AU  - Stahl SM
FAU - van Deerlin, Vivianna
AU  - van Deerlin V
FAU - Stern, Yaakov
AU  - Stern Y
FAU - Weir, David
AU  - Weir D
FAU - Wolk, David A
AU  - Wolk DA
FAU - Trojanowski, John Q
AU  - Trojanowski JQ
LA  - eng
GR  - P30 AG010124/AG/NIA NIH HHS/United States
GR  - R01 AG027161/AG/NIA NIH HHS/United States
GR  - U01 AG009740/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Alzheimers Dement
JT  - Alzheimer's & dementia : the journal of the Alzheimer's Association
JID - 101231978
SB  - IM
MH  - Alzheimer Disease/*diagnosis/epidemiology/*therapy
MH  - Cost-Benefit Analysis/statistics & numerical data
MH  - Female
MH  - *Health Policy
MH  - *Health Services Research
MH  - Humans
MH  - Male
MH  - United States
PMC - PMC3552530
MID - NIHMS432514
EDAT- 2012/09/11 06:00
MHDA- 2013/02/07 06:00
CRDT- 2012/09/11 06:00
PHST- 2012/07/30 00:00 [received]
PHST- 2012/08/01 00:00 [accepted]
PHST- 2012/09/11 06:00 [entrez]
PHST- 2012/09/11 06:00 [pubmed]
PHST- 2013/02/07 06:00 [medline]
AID - S1552-5260(12)02394-1 [pii]
AID - 10.1016/j.jalz.2012.08.001 [doi]
PST - ppublish
SO  - Alzheimers Dement. 2012 Sep;8(5):445-52. doi: 10.1016/j.jalz.2012.08.001.


PMID- 22959637
OWN - NLM
STAT- MEDLINE
DCOM- 20121218
LR  - 20181201
IS  - 1538-3199 (Electronic)
IS  - 1538-3199 (Linking)
VI  - 42
IP  - 9
DP  - 2012 Oct
TI  - Clinical ethical considerations in contraceptive care for teens.
PG  - 264-5
LID - 10.1016/j.cppeds.2012.07.004 [doi]
FAU - Gowda, Sonia P
AU  - Gowda SP
AD  - University of Missouri-Kansas City, Children's Mercy Hospitals and Clinics,
      Kansas City, MO, USA.
FAU - Lantos, John D
AU  - Lantos JD
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Curr Probl Pediatr Adolesc Health Care
JT  - Current problems in pediatric and adolescent health care
JID - 101134613
SB  - IM
CON - Curr Probl Pediatr Adolesc Health Care. 2012 Oct;42(9):221-63. PMID: 22959636
MH  - *Adolescent Behavior
MH  - Adolescent Health Services/*organization & administration
MH  - Contraception/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Sex Education/*organization & administration
MH  - Sexual Behavior/*statistics & numerical data
EDAT- 2012/09/11 06:00
MHDA- 2012/12/19 06:00
CRDT- 2012/09/11 06:00
PHST- 2012/09/11 06:00 [entrez]
PHST- 2012/09/11 06:00 [pubmed]
PHST- 2012/12/19 06:00 [medline]
AID - S1538-5442(12)00116-2 [pii]
AID - 10.1016/j.cppeds.2012.07.004 [doi]
PST - ppublish
SO  - Curr Probl Pediatr Adolesc Health Care. 2012 Oct;42(9):264-5. doi:
      10.1016/j.cppeds.2012.07.004.


PMID- 22959596
OWN - NLM
STAT- MEDLINE
DCOM- 20140714
LR  - 20181202
IS  - 1578-6749 (Electronic)
IS  - 0210-5691 (Linking)
VI  - 37
IP  - 5
DP  - 2013 Jun-Jul
TI  - [Life-sustaining treatment limitation criteria upon admission to the intensive
      care unit: results of a Spanish national multicenter survey].
PG  - 333-8
LID - 10.1016/j.medin.2012.06.002 [doi]
LID - S0210-5691(12)00228-8 [pii]
AB  - OBJECTIVE: To determine the life-sustaining treatment limitation (LSTL)
      predisposition upon patient admission to the intensive care unit (ICU), the
      criteria upon which such predisposition is based, and whether these decisions are
      related to structural factors of the surveyed hospitals. DESIGN: A descriptive
      multicenter study was made in 2010, involving the conduction of a survey in 90
      hospitals, with a view to documenting the usual practice referred to LSTL upon
      admission in these centers. SETTING: Spanish ICUs. INTERVENTION: Opinion survey. 
      MAIN VARIABLES OF INTEREST: Type of hospital, number of hospital beds, ICU and
      semicritical patient beds, usual bed availability in the ICU, use of restrictive 
      admission criteria, use of LSTL criteria upon admission, and type of criterion
      used to decide LSTL. RESULTS: A total of 43 (48%) hospitals participated in the
      study, with LSTL being a common practice in these centers (93%). LSTL was
      fundamentally decided on the basis of the presence of prior severe chronic
      disease (95%), observation of previously declared patient will (95%), prior
      functional limitation (85%), and qualitative futility of care (82%). Frequent ICU
      bed availability (77% of the hospitals) and the use of restrictive criteria (79% 
      of the hospitals) were also associated to patient admission with LSTL.
      CONCLUSIONS: Admission to ICU with LSTL is a generalized practice in Spanish
      Hospitals. LSTL is decided based on physiological futility from an objective
      medical point of view, but also in observance of ethical and moral implications
      based on the qualitative futility of medical care.
CI  - Copyright (c) 2012 Elsevier Espana, S.L. and SEMICYUC. All rights reserved.
FAU - Rubio, O
AU  - Rubio O
AD  - Servicio de Medicina Intensiva, Hospital Sant Joan de Deu, Manresa, Barcelona,
      Espana. Orubio@althaia.cat
FAU - Sanchez, J M
AU  - Sanchez JM
FAU - Fernandez, R
AU  - Fernandez R
LA  - spa
PT  - Journal Article
PT  - Multicenter Study
TT  - Criterios para limitar los tratamientos de soporte vital al ingreso en unidad de 
      cuidados intensivos: resultados de una encuesta multicentrica nacional.
DEP - 20120907
PL  - Spain
TA  - Med Intensiva
JT  - Medicina intensiva
JID - 9207689
SB  - IM
MH  - Humans
MH  - *Intensive Care Units
MH  - Life Support Care/*standards/*statistics & numerical data
MH  - *Patient Admission
MH  - Spain
MH  - Surveys and Questionnaires
EDAT- 2012/09/11 06:00
MHDA- 2014/07/16 06:00
CRDT- 2012/09/11 06:00
PHST- 2012/05/10 00:00 [received]
PHST- 2012/06/15 00:00 [revised]
PHST- 2012/06/16 00:00 [accepted]
PHST- 2012/09/11 06:00 [entrez]
PHST- 2012/09/11 06:00 [pubmed]
PHST- 2014/07/16 06:00 [medline]
AID - S0210-5691(12)00228-8 [pii]
AID - 10.1016/j.medin.2012.06.002 [doi]
PST - ppublish
SO  - Med Intensiva. 2013 Jun-Jul;37(5):333-8. doi: 10.1016/j.medin.2012.06.002. Epub
      2012 Sep 7.


PMID- 22958756
OWN - NLM
STAT- MEDLINE
DCOM- 20130314
LR  - 20211021
IS  - 1471-2393 (Electronic)
IS  - 1471-2393 (Linking)
VI  - 12
DP  - 2012 Sep 9
TI  - Incidence of and socio-biologic risk factors for spontaneous preterm birth in HIV
      positive Nigerian women.
PG  - 93
AB  - BACKGROUND: Recent studies have identified HIV as a leading contributor to
      preterm delivery and its associated morbidity and mortality. However little or no
      information exists in our sub-region on this subject. Identifying the factors
      associated with preterm delivery in HIV positive women in our country and
      sub-region will not only prevent mother to child transmission of HIV virus but
      will also reduce the morbidity and mortality associated with prematurity and low 
      birth weight. This study was designed to determine the incidence and risk factors
      for preterm delivery in HIV positive Nigerians. METHOD: The required data for
      this retrospective study was extracted from the data base of a cohort study of
      the outcome of prevention of mother to child transmission at the Nigerian
      Institute of Medical Research, Lagos. Only data of women that met the eligibility
      of spontaneous delivery after 20 weeks of gestation were included. Ethical
      approval was obtained from the Institution's Ethical Review Board. RESULTS: 181
      women out of the 1626 eligible for inclusion into the study had spontaneous
      preterm delivery (11.1%). The mean birth weight was 3.1 +/- 0.4 kg, with 10.3%
      having LBW. Spontaneous preterm delivery was found to be significantly associated
      with unmarried status (cOR: 1.7;1.52-2.57), baseline CD4 count <200 cells/mm(3)
      (cOR: 1.8; 1.16-2.99), presence of opportunistic infection at delivery (cOR:
      2.2;1.23-3.57), multiple pregnancy (cOR 10.4; 4.24 - 26.17), use of PI based
      triple ARV therapy (eOR 10.2; 5.52 - 18.8) in the first trimester (cOR 2.5; 1.77 
      - 3.52) on univariate analysis. However after multivariate analysis controlling
      for potential confounding variables including low birth weight, only multiple
      pregnancy (aOR: 8.6; CI: 6.73 - 12.9), presence of opportunistic infection at
      delivery (aOR: 1.9; CI: 1.1 - 5.7), and 1st trimester exposure to PI based triple
      therapy (aOR: 5.4; CI: 3.4 - 7.8) retained their significant association with
      preterm delivery. CONCLUSION: The spontaneous preterm delivery rate among our
      cohort was 11.1%. HIV positive women with multiple pregnancies, symptomatic HIV
      infection at delivery and first trimester fetal exposure to PI based triple
      therapy were found to be at risk of spontaneous preterm delivery. Early booking
      and non-use of PI based triple therapy in the first trimester will significantly 
      reduce the risk of preterm delivery.
FAU - Ezechi, Oliver C
AU  - Ezechi OC
AD  - HIV Treatment Centre, Clinical Sciences Division, Nigerian Institute of Medical
      Research, 6 Edmund Crescent, Yaba, Lagos, Nigeria. oezechi@yahoo.co.uk
FAU - David, Agatha N
AU  - David AN
FAU - Gab-Okafor, Chidinma V
AU  - Gab-Okafor CV
FAU - Ohwodo, Harry
AU  - Ohwodo H
FAU - Oladele, David A
AU  - Oladele DA
FAU - Kalejaiye, Olufunto O
AU  - Kalejaiye OO
FAU - Ezeobi, Paschal M
AU  - Ezeobi PM
FAU - Gbajabiamila, Titilola A
AU  - Gbajabiamila TA
FAU - Adu, Rosemary A
AU  - Adu RA
FAU - Oke, Bamidele
AU  - Oke B
FAU - Musa, Zaidat A
AU  - Musa ZA
FAU - Ekama, Sabdat O
AU  - Ekama SO
FAU - Ilesanmi, Oluwafunke
AU  - Ilesanmi O
FAU - Odubela, Olutosin
AU  - Odubela O
FAU - Somefun, Esther O
AU  - Somefun EO
FAU - Herbertson, Ebiere C
AU  - Herbertson EC
FAU - Onwujekwe, Dan I
AU  - Onwujekwe DI
FAU - Ujah, Innocent A O
AU  - Ujah IA
LA  - eng
PT  - Journal Article
DEP - 20120909
PL  - England
TA  - BMC Pregnancy Childbirth
JT  - BMC pregnancy and childbirth
JID - 100967799
RN  - 0 (Antirheumatic Agents)
SB  - IM
MH  - Adult
MH  - Antiretroviral Therapy, Highly Active
MH  - Antirheumatic Agents/therapeutic use
MH  - Female
MH  - HIV Seropositivity/drug therapy/*epidemiology
MH  - Humans
MH  - Incidence
MH  - Nigeria/epidemiology
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/*epidemiology
MH  - *Pregnancy Outcome
MH  - Premature Birth/*epidemiology
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Viral Load
MH  - Young Adult
PMC - PMC3449176
EDAT- 2012/09/11 06:00
MHDA- 2013/03/15 06:00
CRDT- 2012/09/11 06:00
PHST- 2011/07/30 00:00 [received]
PHST- 2012/08/31 00:00 [accepted]
PHST- 2012/09/11 06:00 [entrez]
PHST- 2012/09/11 06:00 [pubmed]
PHST- 2013/03/15 06:00 [medline]
AID - 1471-2393-12-93 [pii]
AID - 10.1186/1471-2393-12-93 [doi]
PST - epublish
SO  - BMC Pregnancy Childbirth. 2012 Sep 9;12:93. doi: 10.1186/1471-2393-12-93.


PMID- 22958696
OWN - NLM
STAT- MEDLINE
DCOM- 20121101
LR  - 20191027
IS  - 0256-9574 (Print)
VI  - 102
IP  - 9
DP  - 2012 Jul 6
TI  - Voluntary informed consent and good clinical practice for clinical research in
      South Africa: ethical and legal perspectives.
PG  - 746-8
AB  - Most differences, shortcomings and contradictions regarding voluntary informed
      consent for participation in clinical research relate to the South
      African-specific guidance documents, i.e. South African Guidelines for Good
      Practice in the Conduct of Clinical Trials with Human Participants in South
      Africa (2006) and Ethics in Health Research: Principles, Structures and Processes
      (2004). These documents do not fulfil all the ethical and legal requirements for 
      voluntary informed consent for clinical research participation in South Africa.
      International guidance documents reflect the minimum of the ethical requirements 
      for the conduct of clinical research. Country-specific documents should be
      updated and aligned with relevant legislative and legal principles of that
      jurisdiction to ensure that research participants are adequately protected. The
      South African-specific guidance documents therefore require revision to address
      these deficiencies.
FAU - Britz, Retha
AU  - Britz R
AD  - Department of Public Law, Stellenbosch University, Western Cape, South Africa.
FAU - le Roux-Kemp, Andra
AU  - le Roux-Kemp A
LA  - eng
PT  - Journal Article
DEP - 20120706
PL  - South Africa
TA  - S Afr Med J
JT  - South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
JID - 0404520
SB  - IM
MH  - Biomedical Research/*ethics/*legislation & jurisprudence
MH  - Humans
MH  - Informed Consent/*ethics/*legislation & jurisprudence
MH  - South Africa
EDAT- 2012/09/11 06:00
MHDA- 2012/11/02 06:00
CRDT- 2012/09/11 06:00
PHST- 2011/12/01 00:00 [received]
PHST- 2012/01/26 00:00 [accepted]
PHST- 2012/09/11 06:00 [entrez]
PHST- 2012/09/11 06:00 [pubmed]
PHST- 2012/11/02 06:00 [medline]
AID - 10.7196/samj.5498 [doi]
PST - epublish
SO  - S Afr Med J. 2012 Jul 6;102(9):746-8. doi: 10.7196/samj.5498.


PMID- 22958055
OWN - NLM
STAT- MEDLINE
DCOM- 20121217
LR  - 20220317
IS  - 1528-1167 (Electronic)
IS  - 0013-9580 (Linking)
VI  - 53
IP  - 10
DP  - 2012 Oct
TI  - An international pilot study of an Internet-based platform to facilitate clinical
      research in epilepsy: the EpiNet project.
PG  - 1829-35
LID - 10.1111/j.1528-1167.2012.03636.x [doi]
AB  - PURPOSE: We created an epilepsy patient database that can be accessed via the
      Internet by neurologists from anywhere in the world. The database was designed to
      enroll and follow large cohorts of patients with specific epilepsy syndromes, and
      to facilitate recruitment of patients for investigator-initiated clinical trials.
      METHODS: The EpiNet database records physician-derived information regarding
      seizure type and frequency, epilepsy syndrome, etiology, drug history, and
      investigations. It can be accessed from any country by approved investigators via
      a secure, password-protected Website. All data are encrypted. The database is for
      both research and clinical purposes. Investigators were invited to register any
      patient with epilepsy, but were particularly encouraged to register patients when
      uncertain of the optimal management. Participation required approval from
      investigators' ethics committees and institutional review boards, and all
      patients or their caregiver provided written informed consent. Patients were not 
      enrolled in clinical trials in this pilot study. KEY FINDINGS: The international 
      pilot study recruited patients from September 2010 to November 2011. Sixty-four
      investigators or research assistants from 25 centers in 13 countries registered
      1,050 patients. Patients with a wide range of epilepsy syndromes and etiologies
      were registered. Patients' ages ranged from 2 weeks to 90 years. SIGNIFICANCE:
      The Website was successfully used by doctors working in different health systems.
      The pilot study confirmed that this low-cost, collaborative approach to research 
      has great potential. Large, multicenter cohort studies will commence in 2012, and
      randomized clinical trials are being planned. All epileptologists are invited to 
      join this project.
CI  - Wiley Periodicals, Inc. (c) 2012 International League Against Epilepsy.
FAU - Bergin, Peter
AU  - Bergin P
AD  - Department of Neurology, Auckland City Hospital, and Centre for Brain Research,
      University of Auckland, Auckland, New Zealand. pbergin@adhb.govt.nz
FAU - Sadleir, Lynette
AU  - Sadleir L
FAU - Legros, Benjamin
AU  - Legros B
FAU - Mogal, Zarine
AU  - Mogal Z
FAU - Tripathi, Manjari
AU  - Tripathi M
FAU - Dang, Nitika
AU  - Dang N
FAU - Beretta, Simone
AU  - Beretta S
FAU - Zanchi, Clara
AU  - Zanchi C
FAU - Burneo, Jorge
AU  - Burneo J
FAU - Borkowski, Thomas
AU  - Borkowski T
FAU - Cho, Yang Je
AU  - Cho YJ
FAU - Ossemann, Michel
AU  - Ossemann M
FAU - Striano, Pasquale
AU  - Striano P
FAU - Srivastava, Kavita
AU  - Srivastava K
FAU - Tan, Hui Jan
AU  - Tan HJ
FAU - Wanigasinghe, Jithangi
AU  - Wanigasinghe J
FAU - D'Souza, Wendyl
AU  - D'Souza W
CN  - EpiNet study group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120907
PL  - United States
TA  - Epilepsia
JT  - Epilepsia
JID - 2983306R
RN  - 0 (Anticonvulsants)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anticonvulsants/*therapeutic use
MH  - Biomedical Research/*methods
MH  - Child
MH  - Child, Preschool
MH  - *Clinical Trials as Topic
MH  - Data Collection/methods
MH  - Databases, Factual/statistics & numerical data
MH  - Epilepsy/classification/*drug therapy/etiology
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - *International Cooperation
MH  - *Internet
MH  - Middle Aged
MH  - Multicenter Studies as Topic
MH  - Patient Selection
MH  - Pilot Projects
MH  - Young Adult
IR  - Kiley M
FIR - Kiley, Michelle
IR  - Carney P
FIR - Carney, Patrick
IR  - Scales G
FIR - Scales, Georgie
IR  - d'Souza W
FIR - d'Souza, Wendyl
IR  - Tan M
FIR - Tan, Michael
IR  - O'Brien T
FIR - O'Brien, Terry
IR  - Germaine D
FIR - Germaine, Darren
IR  - Legros B
FIR - Legros, Benjamin
IR  - Ossemann M
FIR - Ossemann, Michel
IR  - de Fays K
FIR - de Fays, Katalin
IR  - Burneo J
FIR - Burneo, Jorge
IR  - Richardson M
FIR - Richardson, Mark
IR  - Tripathi M
FIR - Tripathi, Manjari
IR  - Dang N
FIR - Dang, Nitika
IR  - Srivastava K
FIR - Srivastava, Kavita
IR  - Beretta S
FIR - Beretta, Simone
IR  - Zanchi C
FIR - Zanchi, Clara
IR  - Beghi E
FIR - Beghi, Ettore
IR  - Striano P
FIR - Striano, Pasquale
IR  - Giudizioso G
FIR - Giudizioso, Giovanna
IR  - Cho YJ
FIR - Cho, Yang-Je
IR  - Lee BI
FIR - Lee, Byung-In
IR  - Ko ES
FIR - Ko, Eun Sook
IR  - Ali R
FIR - Ali, Raymond
IR  - Jan TH
FIR - Jan, Tan Hui
IR  - Anderson N
FIR - Anderson, Neil
IR  - Barber A
FIR - Barber, Alan
IR  - Bergin P
FIR - Bergin, Peter
IR  - Bourke D
FIR - Bourke, David
IR  - Brownlie W
FIR - Brownlie, Wallace
IR  - Campbell E
FIR - Campbell, Eric
IR  - Child N
FIR - Child, Nicholas
IR  - Cleland J
FIR - Cleland, James
IR  - Davis S
FIR - Davis, Sue
IR  - Frith R
FIR - Frith, Richard
IR  - Hutchinson D
FIR - Hutchinson, David
IR  - Kilfoyle D
FIR - Kilfoyle, Dean
IR  - Orizio V
FIR - Orizio, Valerie
IR  - Periera J
FIR - Periera, Jennifer
IR  - Roberts L
FIR - Roberts, Lynair
IR  - Rosemergy I
FIR - Rosemergy, Ian
IR  - Roxburgh R
FIR - Roxburgh, Richard
IR  - Simpson M
FIR - Simpson, Mark
IR  - Sumner D
FIR - Sumner, Diana
IR  - Teoh L
FIR - Teoh, Laurence
IR  - Walker E
FIR - Walker, Elizabeth
IR  - Ward L
FIR - Ward, Lynda
IR  - Willoughby E
FIR - Willoughby, Ernest
IR  - Wong E
FIR - Wong, Edward
IR  - Wood B
FIR - Wood, Barbara
IR  - Wu T
FIR - Wu, Teddy
IR  - Mason D
FIR - Mason, Debbie
IR  - Cutfield N
FIR - Cutfield, Nicholas
IR  - Hammond-Tooke G
FIR - Hammond-Tooke, Graeme
IR  - Mottershead J
FIR - Mottershead, John
IR  - Gilbertson L
FIR - Gilbertson, Linda
IR  - Asztely F
FIR - Asztely, Fredrik
IR  - Cariga P
FIR - Cariga, Pietro
IR  - Ranta A
FIR - Ranta, Anna
IR  - Mossman S
FIR - Mossman, Stuart
IR  - Paterson S
FIR - Paterson, Sarah
IR  - Redshaw N
FIR - Redshaw, Natalie
IR  - Rosemergy I
FIR - Rosemergy, Ian
IR  - Sadleir L
FIR - Sadleir, Lynette
IR  - Yang V
FIR - Yang, Viger
IR  - McGrath N
FIR - McGrath, Nichole
IR  - Mogal Z
FIR - Mogal, Zarine
IR  - Mahmud H
FIR - Mahmud, Hiba
IR  - Baeta E
FIR - Baeta, Elia
IR  - Wanigasinghe J
FIR - Wanigasinghe, Jithangi
IR  - Boro A
FIR - Boro, Alex
IR  - Borkowski T
FIR - Borkowski, Thomas
IR  - Haut S
FIR - Haut, Sheryl
EDAT- 2012/09/11 06:00
MHDA- 2012/12/18 06:00
CRDT- 2012/09/11 06:00
PHST- 2012/09/11 06:00 [entrez]
PHST- 2012/09/11 06:00 [pubmed]
PHST- 2012/12/18 06:00 [medline]
AID - 10.1111/j.1528-1167.2012.03636.x [doi]
PST - ppublish
SO  - Epilepsia. 2012 Oct;53(10):1829-35. doi: 10.1111/j.1528-1167.2012.03636.x. Epub
      2012 Sep 7.


PMID- 22956739
OWN - NLM
STAT- MEDLINE
DCOM- 20141112
LR  - 20130920
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 10
DP  - 2013 Oct
TI  - Human dignity and rights beyond death.
PG  - 651
LID - 10.1136/medethics-2012-100826 [doi]
FAU - Hon, Kam Lun
AU  - Hon KL
LA  - eng
PT  - Journal Article
DEP - 20120906
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
CIN - J Med Ethics. 2013 Oct;39(10):652-3. PMID: 23038798
MH  - Archaeology/*ethics
MH  - *Cadaver
MH  - Humans
MH  - *Personhood
OTO - NOTNLM
OT  - Ethics Committees/Consultation
OT  - History of Health Ethics/Bioethics
EDAT- 2012/09/08 06:00
MHDA- 2014/11/13 06:00
CRDT- 2012/09/08 06:00
PHST- 2012/09/08 06:00 [entrez]
PHST- 2012/09/08 06:00 [pubmed]
PHST- 2014/11/13 06:00 [medline]
AID - medethics-2012-100826 [pii]
AID - 10.1136/medethics-2012-100826 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Oct;39(10):651. doi: 10.1136/medethics-2012-100826. Epub 2012 
      Sep 6.


PMID- 22956643
OWN - NLM
STAT- MEDLINE
DCOM- 20130131
LR  - 20220331
IS  - 1471-6771 (Electronic)
IS  - 0007-0912 (Linking)
VI  - 109
IP  - 6
DP  - 2012 Dec
TI  - i-gel supraglottic airway in clinical practice: a prospective observational
      multicentre study.
PG  - 990-5
LID - 10.1093/bja/aes309 [doi]
AB  - BACKGROUND: The i-gel supraglottic airway device has been studied in randomized
      controlled studies, but it has not been evaluated in a large prospective patient 
      cohort. Therefore, we performed this prospective multicentre observational study 
      to evaluate success rates, airway leak pressure, risk factors for i-gel failure, 
      and adverse events. METHODS: With Ethics Committee approval and waiver of
      patients' consent, data about anaesthesia providers, patient characteristics, and
      the performance of the i-gel were recorded in five independent hospitals in
      Switzerland over a period of 24 months. We analysed success rates, leak
      pressures, adverse events, and risk factors for failure. RESULTS: Data from 2049 
      i-gel uses were analysed. Patients' mean age was 47 (range 6-91) yr. The primary 
      i-gel success rate without changing size was 93%; the overall success rate was
      96%. Insertion was deemed very easy or easy in 92%. The mean airway leak pressure
      was 26 (8) cm H(2)O. The mean anaesthesia time was 67 (42) min. Risk factors
      associated with i-gel failure were males (P<0.001), impaired mandibular
      subluxation (P=0.01), poor dentition (P=0.02), and older age (P<0.01). Adverse
      events recorded were laryngeal spasms (n=25, 1.2%), blood stained airway devices 
      (n=79, 3.9%), transient nerve damage (n=2, 0.1%), one case of transient vasovagal
      asystole, and one glottic haematoma. CONCLUSIONS: The i-gel is a reliable
      supraglottic airway device failing in <5% and providing high airway leak
      pressures. Males, impaired mandibular subluxation, poor dentition, and older age 
      are risk factors associated with primary device failure. Serious adverse events
      are rare.
FAU - Theiler, L
AU  - Theiler L
AD  - Department of Anesthesiology, Perioperative Medicine and Pain Management,
      University of Miami Miller School of Medicine, Gautier Bldg, Room 415, 1011 N.W. 
      15th Street, Miami, FL 33136, USA. lorenz.theiler@insel.ch
FAU - Gutzmann, M
AU  - Gutzmann M
FAU - Kleine-Brueggeney, M
AU  - Kleine-Brueggeney M
FAU - Urwyler, N
AU  - Urwyler N
FAU - Kaempfen, B
AU  - Kaempfen B
FAU - Greif, R
AU  - Greif R
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20120906
PL  - England
TA  - Br J Anaesth
JT  - British journal of anaesthesia
JID - 0372541
SB  - IM
CIN - Br J Anaesth. 2014 Feb;112(2):386-7. PMID: 24431360
CIN - Br J Anaesth. 2014 Feb;112(2):387. PMID: 24431361
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - Disposable Equipment
MH  - Equipment Design
MH  - Equipment Failure
MH  - Female
MH  - Humans
MH  - Intubation, Intratracheal/*instrumentation/methods
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Risk Factors
MH  - Sex Factors
MH  - Switzerland
MH  - Young Adult
EDAT- 2012/09/08 06:00
MHDA- 2013/02/01 06:00
CRDT- 2012/09/08 06:00
PHST- 2012/09/08 06:00 [entrez]
PHST- 2012/09/08 06:00 [pubmed]
PHST- 2013/02/01 06:00 [medline]
AID - S0007-0912(17)31607-0 [pii]
AID - 10.1093/bja/aes309 [doi]
PST - ppublish
SO  - Br J Anaesth. 2012 Dec;109(6):990-5. doi: 10.1093/bja/aes309. Epub 2012 Sep 6.


PMID- 22956020
OWN - NLM
STAT- MEDLINE
DCOM- 20130208
LR  - 20211021
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 24
IP  - 3
DP  - 2012 Sep
TI  - Grassroots origins, national engagement: exploring the professionalization of
      practicing healthcare ethicists in Canada.
PG  - 153-64
AB  - Canadian ethicists have a long legacy of leadership in advocating for standards
      and quality in healthcare ethics. Continuing this tradition, a grassroots
      organization of practicing healthcare ethicists (PHEs) concerned about the lack
      of standardization in the field recently formed to explore potential options
      related to professionalization. This group calls itself "practicing healthcare
      ethicists exploring professionalization" (PHEEP). This paper provides a
      description of the process by which PHEEP has begun to engage the Canadian PHE
      community in the development of practice standards and related projects. By
      making our process and its ethical and cultural underpinnings transparent, we
      hope to prompt PHEs around the world to reflect on the importance of context,
      process and principles (not just outcomes) in the exploration of and possible
      movement towards professionalization. By sharing some of our key successes and
      challenges, we also hope to inspire our colleagues to recognize the value in
      developing practice standards and to contribute to this endeavor.
FAU - Frolic, Andrea
AU  - Frolic A
AD  - Faculty of Health Sciences, Hamilton Health Sciences, McMaster University Medical
      Center, Hamilton, ON, Canada. frolic@hhsc.ca
CN  - Practicing Healthcare Ethicists Exploring Professionalization (PHEEP) Steering
      Committee
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - *Bioethics
MH  - Canada
MH  - Congresses as Topic
MH  - Delivery of Health Care/ethics
MH  - Ethicists/*standards
MH  - Humans
MH  - *Professional Competence
MH  - *Professional Role
IR  - Cline C
FIR - Cline, Cheryl
IR  - d'Agincourt-Canning L
FIR - d'Agincourt-Canning, Lori
IR  - Frolic A
FIR - Frolic, Andrea
IR  - Goldsand G
FIR - Goldsand, Gary
IR  - Heesters A
FIR - Heesters, Ann
IR  - Kirby J
FIR - Kirby, Jeff
IR  - Reel K
FIR - Reel, Kevin
IR  - Roigt D
FIR - Roigt, Delphine
IR  - Secker B
FIR - Secker, Barbara
IR  - Simpson C
FIR - Simpson, Christy
EDAT- 2012/09/08 06:00
MHDA- 2013/02/09 06:00
CRDT- 2012/09/08 06:00
PHST- 2012/09/08 06:00 [entrez]
PHST- 2012/09/08 06:00 [pubmed]
PHST- 2013/02/09 06:00 [medline]
AID - 10.1007/s10730-012-9192-y [doi]
PST - ppublish
SO  - HEC Forum. 2012 Sep;24(3):153-64. doi: 10.1007/s10730-012-9192-y.


PMID- 22955387
OWN - NLM
STAT- MEDLINE
DCOM- 20130402
LR  - 20181201
IS  - 1938-2367 (Electronic)
IS  - 0147-7447 (Linking)
VI  - 35
IP  - 9
DP  - 2012 Sep
TI  - Potential of placenta-derived mesenchymal stem cells as seed cells for bone
      tissue engineering: preliminary study of osteoblastic differentiation and
      immunogenicity.
PG  - 779-88
LID - 10.3928/01477447-20120822-07 [doi]
AB  - Mesenchymal stem cells (MSCs) have been isolated from a variety of human tissues 
      (eg, bone marrow, peripheral blood, muscle, fat, umbilical blood, amniotic fluid,
      embryonic tissues, and placenta). Placenta-derived MSCs (PDMSCs) have received
      considerable interest because of their wide availability and absence of ethical
      concerns. The authors characterized the biological properties, ultrastructure,
      growth factor production, and osteoblastic differentiation of PDMSCs and
      investigated their potential as seed cells for bone tissue engineering.
CI  - Copyright 2012, SLACK Incorporated.
FAU - Zhong, Zhi-Nian
AU  - Zhong ZN
AD  - Department of Orthopedics, First Hospital of Shaoguan, Guangdong Medical College,
      Guangdong, China.
FAU - Zhu, Shao-Fang
AU  - Zhu SF
FAU - Yuan, Ai-Dong
AU  - Yuan AD
FAU - Lu, Guo-Hui
AU  - Lu GH
FAU - He, Zheng-Yan
AU  - He ZY
FAU - Fa, Zhi-Qiang
AU  - Fa ZQ
FAU - Li, Wen-Hu
AU  - Li WH
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Orthopedics
JT  - Orthopedics
JID - 7806107
SB  - IM
MH  - Batch Cell Culture Techniques/methods
MH  - Cell Differentiation/immunology
MH  - Cell Proliferation
MH  - Cells, Cultured
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Mesenchymal Stem Cells/*cytology/*immunology
MH  - Osteoblasts/*cytology/*immunology
MH  - Osteogenesis/*immunology
MH  - Pilot Projects
MH  - Placenta
MH  - Pregnancy
MH  - Tissue Engineering/*methods
EDAT- 2012/09/08 06:00
MHDA- 2013/04/03 06:00
CRDT- 2012/09/08 06:00
PHST- 2012/09/08 06:00 [entrez]
PHST- 2012/09/08 06:00 [pubmed]
PHST- 2013/04/03 06:00 [medline]
AID - 10.3928/01477447-20120822-07 [doi]
PST - ppublish
SO  - Orthopedics. 2012 Sep;35(9):779-88. doi: 10.3928/01477447-20120822-07.


PMID- 22955240
OWN - NLM
STAT- MEDLINE
DCOM- 20130205
LR  - 20120907
IS  - 1945-2810 (Electronic)
IS  - 0888-0395 (Linking)
VI  - 44
IP  - 5
DP  - 2012 Oct
TI  - Nursing care of patients with disorders of consciousness.
PG  - 260-70
AB  - Management of severely brain-injured patients constitutes a social, economical,
      and ethical dilemma as well as a real challenge for the medical staff, as it
      requires specific expertise. The aim of this article is to explore the aspects of
      nursing care in patients recovering from coma such as difficulty of diagnosis,
      residual perception, clinical assessment, care and management, and communication 
      with the patient and the family. The nursing care of patients with disorder of
      consciousness must be particular and specific for various reasons such as the
      difficult diagnosis, the problem of unconsciousness or lack of demonstration of
      consciousness, extremely complex clinical assessment, daily management with total
      dependence, communication with patients that requires special attention and
      training by health professionals, and communication with the family of these
      patients that requires more sensitivity and full involvement by the team.
FAU - Puggina, Ana Claudia Giesbrecht
AU  - Puggina AC
AD  - Research Group about Communication in Nursing at School of Nursing, University of
      Sao Paulo, Sao Paulo, Brazil. claudiapuggina@usp.br
FAU - Paes da Silva, Maria Julia
AU  - Paes da Silva MJ
FAU - Schnakers, Caroline
AU  - Schnakers C
FAU - Laureys, Steven
AU  - Laureys S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci Nurs
JT  - The Journal of neuroscience nursing : journal of the American Association of
      Neuroscience Nurses
JID - 8603596
SB  - IM
MH  - Coma/diagnosis/*nursing
MH  - Communication
MH  - Diagnosis, Differential
MH  - Humans
MH  - Nursing Assessment/methods
MH  - Persistent Vegetative State/diagnosis/*nursing
MH  - Professional-Family Relations
EDAT- 2012/09/08 06:00
MHDA- 2013/02/06 06:00
CRDT- 2012/09/08 06:00
PHST- 2012/09/08 06:00 [entrez]
PHST- 2012/09/08 06:00 [pubmed]
PHST- 2013/02/06 06:00 [medline]
AID - 10.1097/JNN.0b013e3182666407 [doi]
AID - 01376517-201210000-00006 [pii]
PST - ppublish
SO  - J Neurosci Nurs. 2012 Oct;44(5):260-70. doi: 10.1097/JNN.0b013e3182666407.


PMID- 22955165
OWN - NLM
STAT- MEDLINE
DCOM- 20121119
LR  - 20181201
IS  - 1534-6080 (Electronic)
IS  - 0041-1337 (Linking)
VI  - 94
IP  - 5
DP  - 2012 Sep 15
TI  - Human tissue authority responds to research in transplantation: update from the
      UK Donation Ethics Committee.
PG  - e26
LID - 10.1097/TP.0b013e318263adb5 [doi]
FAU - Clamp, Alan
AU  - Clamp A
LA  - eng
PT  - Letter
PT  - Comment
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
SB  - IM
CON - Transplantation. 2012 May 15;93(9):860-4. PMID: 22411561
MH  - *Biomedical Research
MH  - Humans
MH  - Informed Consent/*legislation & jurisprudence
MH  - *Tissue Donors
MH  - Tissue and Organ Procurement/*legislation & jurisprudence
EDAT- 2012/09/08 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/09/08 06:00
PHST- 2012/09/08 06:00 [entrez]
PHST- 2012/09/08 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1097/TP.0b013e318263adb5 [doi]
AID - 00007890-201209150-00019 [pii]
PST - ppublish
SO  - Transplantation. 2012 Sep 15;94(5):e26. doi: 10.1097/TP.0b013e318263adb5.


PMID- 22955025
OWN - NLM
STAT- MEDLINE
DCOM- 20130206
LR  - 20161125
IS  - 1536-0210 (Electronic)
IS  - 0020-9996 (Linking)
VI  - 47
IP  - 10
DP  - 2012 Oct
TI  - Magnetic resonance elastography as a predictor of insufficient liver enhancement 
      on gadoxetic acid-enhanced hepatocyte-phase magnetic resonance imaging in
      patients with type C hepatitis and Child-Pugh class A disease.
PG  - 566-70
LID - 10.1097/RLI.0b013e318260ac9e [doi]
AB  - OBJECTIVES: The aim of this study was to examine liver stiffness value measured
      by magnetic resonance elastography (MRE) and laboratory test results to find the 
      best method for predicting insufficient liver enhancement on gadoxetic
      acid-enhanced hepatocyte-phase images. MATERIALS AND METHODS: The institutional
      ethics committee approved this retrospective study with waiver of informed
      consent. In total, 118 patients with Child-Pugh class A disease and type C
      hepatitis underwent MRE and gadoxetic acid-enhanced magnetic resonance imaging.
      During MRE examination, a pneumatic passive driver was used to obtain liver
      stiffness in kPa. Liver enhancement was assessed using liver-to-spleen contrast
      ratio (LSR), calculated using signal intensities of the liver and spleen on
      hepatocyte-phase magnetic resonance images obtained 20 minutes after contrast
      administration of gadoxetic acid. Insufficient liver enhancement was defined as
      an LSR lower than 1.5. The following laboratory test results were used as
      possible predictors of insufficient liver enhancement as well as liver stiffness 
      measured by MRE: albumin, total bilirubin, aspartate aminotransferase, percentage
      prothrombin time, and platelet count. Correlation coefficients were calculated
      between LSR and these variables. Logistic analysis was performed to determine
      independent predictors of insufficient liver enhancement. RESULTS: All possible
      predictors investigated were significantly correlated with LSR. Logistic
      regression analysis revealed that MRE was the only variable to predict
      insufficient liver enhancement, with an odds ratio (95% confidence interval) of
      2.03 (1.22-3.85) (P = 0.0138). A cutoff value of greater than 6.4 kPa yielded 95%
      specificity for predicting insufficient liver enhancement. CONCLUSION: Gadoxetic 
      acid is not recommended in patients with liver stiffness greater than 6.4 kPa
      (consistent with severe fibrosis) because of insufficient liver enhancement on
      hepatocyte-phase images.
FAU - Motosugi, Utaroh
AU  - Motosugi U
AD  - Department of Radiology, University of Yamanashi, Chuo-shi, Yamanashi, Japan.
      utaroh-motosugi@nifty.com
FAU - Ichikawa, Tomoaki
AU  - Ichikawa T
FAU - Muhi, Ali
AU  - Muhi A
FAU - Sano, Katsuhiro
AU  - Sano K
FAU - Morisaka, Hiroyuki
AU  - Morisaka H
FAU - Ichikawa, Shintaro
AU  - Ichikawa S
FAU - Araki, Tsutomu
AU  - Araki T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Invest Radiol
JT  - Investigative radiology
JID - 0045377
RN  - 0 (gadolinium ethoxybenzyl DTPA)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Confidence Intervals
MH  - *Elasticity Imaging Techniques
MH  - *Gadolinium DTPA
MH  - Hepatitis C/diagnosis/*diagnostic imaging/pathology
MH  - Hepatocytes/*radiation effects
MH  - Humans
MH  - Liver/*radiation effects
MH  - Logistic Models
MH  - Odds Ratio
MH  - Radiography
MH  - Retrospective Studies
EDAT- 2012/09/08 06:00
MHDA- 2013/02/07 06:00
CRDT- 2012/09/08 06:00
PHST- 2012/09/08 06:00 [entrez]
PHST- 2012/09/08 06:00 [pubmed]
PHST- 2013/02/07 06:00 [medline]
AID - 10.1097/RLI.0b013e318260ac9e [doi]
AID - 00004424-201210000-00003 [pii]
PST - ppublish
SO  - Invest Radiol. 2012 Oct;47(10):566-70. doi: 10.1097/RLI.0b013e318260ac9e.


PMID- 22954882
OWN - NLM
STAT- MEDLINE
DCOM- 20130107
LR  - 20120907
IS  - 0926-9630 (Print)
IS  - 0926-9630 (Linking)
VI  - 181
DP  - 2012
TI  - Psychosocial implications of avatar use in supporting therapy for depression.
PG  - 329-33
AB  - Help4Mood is a novel intervention to support the treatment of depressive disorder
      using an embodied communicative agent (Avatar) to engage the user with therapy
      tasks. We conducted 10 focus groups with patients and mental health
      professionals, in the UK, Spain and Romania, in order to explore issues around
      usability and contextual fit. Emergent themes related to the design and use of
      Avatars indicated the value of configurability for optimising personalisation and
      perceived trustworthiness; the importance of supplementing rather than replacing 
      face-to-face interaction, and perceptions of the agent as therapeutic ally or
      supportive friend. The use of Avatars in psychotherapy is relatively new and its 
      acceptability, value and risks are unknown. These results indicate that users
      wish to engage with Avatars that meet their personal preferences and fit
      appropriate role expectations. The perception of Avatar as colleague or friend
      raises conceptual and ethical issues which merit further research.
FAU - Pagliari, Claudia
AU  - Pagliari C
AD  - Centre for Population Health Sciences, University of Edinburgh, UK.
      Claudia.pagliari@ed.ac.uk
FAU - Burton, Christopher
AU  - Burton C
FAU - McKinstry, Brian
AU  - McKinstry B
FAU - Szentatotai, Aurora
AU  - Szentatotai A
FAU - David, Daniel
AU  - David D
FAU - Serrano Blanco, Antoni
AU  - Serrano Blanco A
FAU - Ferrini, Luis
AU  - Ferrini L
FAU - Albertini, Susanna
AU  - Albertini S
FAU - Castro, Joan Carlos
AU  - Castro JC
FAU - Estevez, Soraya
AU  - Estevez S
FAU - Wolters, Maria
AU  - Wolters M
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Stud Health Technol Inform
JT  - Studies in health technology and informatics
JID - 9214582
MH  - Depressive Disorder/*rehabilitation
MH  - Focus Groups
MH  - Humans
MH  - Psychotherapy/*methods
MH  - Therapy, Computer-Assisted/*methods
MH  - Trust
MH  - *User-Computer Interface
EDAT- 2012/09/08 06:00
MHDA- 2013/01/08 06:00
CRDT- 2012/09/08 06:00
PHST- 2012/09/08 06:00 [entrez]
PHST- 2012/09/08 06:00 [pubmed]
PHST- 2013/01/08 06:00 [medline]
PST - ppublish
SO  - Stud Health Technol Inform. 2012;181:329-33.


PMID- 22953647
OWN - NLM
STAT- MEDLINE
DCOM- 20120919
LR  - 20171116
IS  - 1128-3602 (Print)
IS  - 1128-3602 (Linking)
VI  - 16
IP  - 7
DP  - 2012 Jul
TI  - The role of oxidized regenerate cellulose to prevent cosmetic defects in
      oncoplastic breast surgery.
PG  - 966-71
AB  - BACKGROUND: Breast conserving surgery (BCS) combined with postoperative
      radiotherapy has become the gold standard of locoregional treatment for the
      majority of patients with early-stage breast cancer, offering equivalent survival
      and improved body image and lifestyle scores as compared to mastectomy. In an
      attempt to optimize the oncologic safety and cosmetic results of BCS, oncoplastic
      procedures (OPP) have been introduced in recent years combining the best
      principles of surgical oncology with those of plastic surgery. However, even with
      the use of OPP, cosmetic outcomes may result unsatisfying when a large volume of 
      parenchyma has to be removed, particularly in small-medium size breasts. AIM: The
      aim of this article is to report our preliminary results with the use of oxidized
      regenerate cellulose (ORC) (Tabotamp fibrillar, Johnson & Johnson; Ethicon, USA) 
      as an agent to prevent cosmetic defects in patients undergoing OPP for breast
      cancer and to analyze the technical refinements that can enhance its efficacy in 
      optimizing cosmetic defects. METHODS: Different OPP are selected based on the
      location and size of the tumor as well as volume and shape of the breast. After
      excision of the tumor, glandular flaps are created by dissection of the residual 
      parenchyma from the pectoralis and serratus muscles and from the skin. After
      careful haemostasis, five layers of ORC are positioned on the pectoralis major in
      the residual cavity and covered by advancement of the glandular flaps. Two
      additional layers of ORC are positioned above the flaps and covered by
      cutaneous-subcutaenous flaps. RESULTS: The use of ORC after OPP has shown
      promising preliminary results, indicating a good tolerability and positive
      effects on cosmesis. CONCLUSIONS: This simple and reliable surgical technique may
      allow not only to reduce the rate of post-operative bleeding and infection at the
      surgical site but also to improve cosmetic results.
FAU - Franceschini, G
AU  - Franceschini G
AD  - Multidisciplinary Breast Center, School of Medicine,Catholic University of the
      "Sacred Heart", Rome, Italy. franceschinigianluca@gmail.com
FAU - Visconti, G
AU  - Visconti G
FAU - Terribile, D
AU  - Terribile D
FAU - Fabbri, C
AU  - Fabbri C
FAU - Magno, S
AU  - Magno S
FAU - Di Leone, A
AU  - Di Leone A
FAU - Salgarello, M
AU  - Salgarello M
FAU - Masetti, R
AU  - Masetti R
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Eur Rev Med Pharmacol Sci
JT  - European review for medical and pharmacological sciences
JID - 9717360
RN  - 0 (Cellulose, Oxidized)
RN  - 0 (Depsipeptides)
RN  - 4LSZ9C5HOB (didemnins)
SB  - IM
MH  - Breast Neoplasms/pathology/*surgery
MH  - Cellulose, Oxidized/*therapeutic use
MH  - Cicatrix/etiology/prevention & control
MH  - Depsipeptides
MH  - Female
MH  - Humans
MH  - *Mammaplasty/adverse effects
MH  - *Mastectomy, Segmental/adverse effects
MH  - Postoperative Hemorrhage/etiology/prevention & control
MH  - Rome
MH  - *Surgical Flaps/adverse effects
MH  - Surgical Wound Infection/etiology/prevention & control
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2012/09/08 06:00
MHDA- 2012/09/20 06:00
CRDT- 2012/09/08 06:00
PHST- 2012/09/08 06:00 [entrez]
PHST- 2012/09/08 06:00 [pubmed]
PHST- 2012/09/20 06:00 [medline]
PST - ppublish
SO  - Eur Rev Med Pharmacol Sci. 2012 Jul;16(7):966-71.


PMID- 22953403
OWN - NLM
STAT- MEDLINE
DCOM- 20120924
LR  - 20161125
IS  - 0029-6570 (Print)
IS  - 0029-6570 (Linking)
VI  - 26
IP  - 51
DP  - 2012 Aug 22-28
TI  - Cardiopulmonary resuscitation in end of life care.
PG  - 35-42
AB  - This article discusses ethical, legal and professional issues surrounding 'do not
      attempt cardiopulmonary resuscitation' (DNACPR) decisions in end of life care.
      The principles outlined throughout this article are applicable in any care
      setting. It explains what a DNACPR decision is, its relevance to clinical
      practice, and provides guidance on decision making and its implementation. The
      article also discusses the ethical considerations when discussing DNACPR
      decisions with patients and families, as well as the legal issues surrounding
      advance decisions to refuse treatment. Case studies are used to link theory to
      practice.
FAU - Reynolds, Joanne
AU  - Reynolds J
AD  - Wirral Community NHS Trust.
FAU - Croft, Sue
AU  - Croft S
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Stand
JT  - Nursing standard (Royal College of Nursing (Great Britain) : 1987)
JID - 9012906
MH  - *Cardiopulmonary Resuscitation
MH  - Decision Making
MH  - Humans
MH  - *Terminal Care
MH  - United Kingdom
EDAT- 2012/09/08 06:00
MHDA- 2012/09/25 06:00
CRDT- 2012/09/08 06:00
PHST- 2012/09/08 06:00 [entrez]
PHST- 2012/09/08 06:00 [pubmed]
PHST- 2012/09/25 06:00 [medline]
AID - 10.7748/ns2012.08.26.51.35.c9242 [doi]
PST - ppublish
SO  - Nurs Stand. 2012 Aug 22-28;26(51):35-42. doi: 10.7748/ns2012.08.26.51.35.c9242.


PMID- 22953382
OWN - NLM
STAT- MEDLINE
DCOM- 20121101
LR  - 20120907
IS  - 8756-8160 (Print)
IS  - 8756-8160 (Linking)
VI  - 28
IP  - 1
DP  - 2012 Summer
TI  - Other people's lives: reflections on medicine, ethics, and euthanasia.
PG  - 71-87
FAU - Fenigsen, Richard
AU  - Fenigsen R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Issues Law Med
JT  - Issues in law & medicine
JID - 8511295
SB  - IM
MH  - Euthanasia/*ethics
MH  - Humans
MH  - Netherlands
MH  - *Public Opinion
MH  - Right to Die
EDAT- 2012/09/08 06:00
MHDA- 2012/11/02 06:00
CRDT- 2012/09/08 06:00
PHST- 2012/09/08 06:00 [entrez]
PHST- 2012/09/08 06:00 [pubmed]
PHST- 2012/11/02 06:00 [medline]
PST - ppublish
SO  - Issues Law Med. 2012 Summer;28(1):71-87.


PMID- 22953011
OWN - NLM
STAT- MEDLINE
DCOM- 20130103
LR  - 20211021
IS  - 1935-2735 (Electronic)
IS  - 1935-2727 (Linking)
VI  - 6
IP  - 8
DP  - 2012
TI  - The importance of long-term social research in enabling participation and
      developing engagement strategies for new dengue control technologies.
PG  - e1785
LID - 10.1371/journal.pntd.0001785 [doi]
AB  - BACKGROUND: In recent years, new strategies aimed at reducing the capacity of
      mosquito vectors to transmit dengue fever have emerged. As with earlier control
      methods, they will have to be employed in a diverse range of communities across
      the globe and into the main settings for disease transmission, the homes,
      businesses and public buildings of residents in dengue-affected areas. However,
      these strategies are notably different from previous methods and draw on
      technologies that are not without controversy. Public engagement and
      authorization are critical to the future success of these programs.
      METHODOLOGY/PRINCIPAL FINDINGS: This paper reports on an Australian case study
      where long-term social research was used to enable participation and the design
      of an engagement strategy tailored specifically to the sociopolitical setting of 
      a potential trial release site of Wolbachia-infected Aedes aegytpi mosquitoes.
      Central themes of the social research, methods used and conclusions drawn are
      briefly described. Results indicate that different communities are likely to have
      divergent expectations, concerns and cultural sensibilities with regard to
      participation, engagement and authorization. CONCLUSIONS/SIGNIFICANCE: The
      findings show that a range of issues need to be understood and taken into account
      to enable sensitive, ethical and effective engagement when seeking public support
      for new dengue control methods.
FAU - McNaughton, Darlene
AU  - McNaughton D
AD  - Discipline of Public Health, Flinders University, Adelaide, South Australia,
      Australia. darlene.mcnaughton@flinders.edu.au
LA  - eng
PT  - Journal Article
DEP - 20120828
PL  - United States
TA  - PLoS Negl Trop Dis
JT  - PLoS neglected tropical diseases
JID - 101291488
SB  - IM
MH  - Adolescent
MH  - Aedes/microbiology
MH  - Aged
MH  - Aged, 80 and over
MH  - Animals
MH  - Australia
MH  - Child
MH  - Child, Preschool
MH  - Dengue/*prevention & control
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Middle Aged
MH  - Mosquito Control/*methods
MH  - Patient Acceptance of Health Care/*psychology
MH  - Wolbachia/growth & development
MH  - Young Adult
PMC - PMC3429396
EDAT- 2012/09/07 06:00
MHDA- 2013/01/04 06:00
CRDT- 2012/09/07 06:00
PHST- 2012/02/05 00:00 [received]
PHST- 2012/07/05 00:00 [accepted]
PHST- 2012/09/07 06:00 [entrez]
PHST- 2012/09/07 06:00 [pubmed]
PHST- 2013/01/04 06:00 [medline]
AID - 10.1371/journal.pntd.0001785 [doi]
AID - PNTD-D-12-00188 [pii]
PST - ppublish
SO  - PLoS Negl Trop Dis. 2012;6(8):e1785. doi: 10.1371/journal.pntd.0001785. Epub 2012
      Aug 28.


PMID- 22952615
OWN - NLM
STAT- MEDLINE
DCOM- 20130219
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 8
DP  - 2012
TI  - Reviews of functional MRI: the ethical dimensions of methodological critique.
PG  - e42836
LID - 10.1371/journal.pone.0042836 [doi]
AB  - Neuroimaging studies involving human subjects raise a range of ethics issues.
      Many of these issues are heightened in the context of neuroimaging research
      involving persons with mental health disorders. There has been growing interest
      in these issues among legal scholars, philosophers, social scientists, and as
      well as neuroimagers over the last decade. Less clear, however, is the extent to 
      which members of the neuroimaging community are engaged with these issues when
      they undertake their research and report results. In this study, we analyze the
      peer-reviewed review literature involving fMRI as applied to the study of mental 
      health disorders. Our hypothesis is that, due to the critical orientation of
      reviews, and the vulnerability of mental health population, the penetrance of
      neuroethics will be higher in the review literature in this area than it is in
      the primary fMRI research literature more generally. We find that while authors
      of reviews do focus a great deal of attention on the methodological limitations
      of the studies they discussed, contrary to our hypothesis, they do not frame
      concerns in ethical terms despite their ethical significance. We argue that an
      ethics lens on such discussion would increase the knowledge-value of this
      scholarly work.
FAU - Anderson, James
AU  - Anderson J
AD  - National Core for Neuroethics, University of British Columbia, Vancouver, British
      Columbia, Canada.
FAU - Mizgalewicz, Ania
AU  - Mizgalewicz A
FAU - Illes, Judy
AU  - Illes J
LA  - eng
GR  - R01 MH084282/MH/NIMH NIH HHS/United States
GR  - 85117/CAPMC/ CIHR/Canada
GR  - 9R01MH84282-06/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120828
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Anxiety Disorders/physiopathology
MH  - Attention Deficit Disorder with Hyperactivity/physiopathology
MH  - *Ethics, Medical
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Mental Health Services/ethics/organization & administration
MH  - Meta-Analysis as Topic
MH  - Mood Disorders/physiopathology
MH  - Neuroimaging/*methods
MH  - Research Design
MH  - *Review Literature as Topic
MH  - Schizophrenia/physiopathology
PMC - PMC3429464
EDAT- 2012/09/07 06:00
MHDA- 2013/02/21 06:00
CRDT- 2012/09/07 06:00
PHST- 2012/05/24 00:00 [received]
PHST- 2012/07/11 00:00 [accepted]
PHST- 2012/09/07 06:00 [entrez]
PHST- 2012/09/07 06:00 [pubmed]
PHST- 2013/02/21 06:00 [medline]
AID - 10.1371/journal.pone.0042836 [doi]
AID - PONE-D-12-14646 [pii]
PST - ppublish
SO  - PLoS One. 2012;7(8):e42836. doi: 10.1371/journal.pone.0042836. Epub 2012 Aug 28.


PMID- 22952384
OWN - NLM
STAT- MEDLINE
DCOM- 20130211
LR  - 20191210
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 265
IP  - 3
DP  - 2012 Dec
TI  - Screening of illegal intracorporeal containers ("body packing"): is abdominal
      radiography sufficiently accurate? A comparative study with low-dose CT.
PG  - 772-9
LID - 10.1148/radiol.12112767 [doi]
AB  - PURPOSE: To evaluate the diagnostic performance of abdominal radiography in the
      detection of illegal intracorporeal containers (hereafter, packets), with
      low-dose computed tomography (CT) as the reference standard. MATERIALS AND
      METHODS: This study was approved by the institutional ethical review board, with 
      written informed consent. From July 2007 to July 2010, 330 people (296 men, 34
      women; mean age, 32 years [range, 18-55 years]) suspected of having ingested drug
      packets underwent supine abdominal radiography and low-dose CT. The presence or
      absence of packets at abdominal radiography was reported, with low-dose CT as the
      reference standard. The density and number of packets (</= 12 or >12) at low-dose
      CT were recorded and analyzed to determine whether those variables influence
      interpretation of results at abdominal radiography. RESULTS: Packets were
      detected at low-dose CT in 53 (16%) suspects. Sensitivity of abdominal
      radiography for depiction of packets was 0.77 (41 of 53), and specificity was
      0.96 (267 of 277). The packets appeared isoattenuated to the bowel contents at
      low-dose CT in 16 (30%) of the 53 suspects with positive results. Nineteen (36%) 
      of the 53 suspects with positive low-dose CT results had fewer than 12 packets.
      Packets that were isoattenuated at low-dose CT and a low number of packets
      (</=12) were both significantly associated with false-negative results at
      abdominal radiography (P = .004 and P = .016, respectively). CONCLUSION:
      Abdominal radiography is mainly limited by low sensitivity when compared with
      low-dose CT in the screening of people suspected of carrying drug packets.
      Low-dose CT is an effective imaging alternative to abdominal radiography.
CI  - (c) RSNA, 2012.
FAU - Poletti, Pierre-Alexandre
AU  - Poletti PA
AD  - Department of Radiology, Emergency Center, Department of Forensic Medicine, and
      Division of Clinical Epidemiology, University Hospital of Geneva, 4 rue Gabrielle
      Perret-Gentil, 1211 Geneva 14, Switzerland. erre-alexandre.poletti@hcuge.ch
FAU - Canel, Laurent
AU  - Canel L
FAU - Becker, Christoph D
AU  - Becker CD
FAU - Wolff, Hans
AU  - Wolff H
FAU - Elger, Bernice
AU  - Elger B
FAU - Lock, Eric
AU  - Lock E
FAU - Sarasin, Francois
AU  - Sarasin F
FAU - Bonfanti, Monica S
AU  - Bonfanti MS
FAU - Dupuis-Lozeron, Elise
AU  - Dupuis-Lozeron E
FAU - Perneger, Thomas
AU  - Perneger T
FAU - Platon, Alexandra
AU  - Platon A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120905
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Illicit Drugs)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - Foreign Bodies/*diagnostic imaging
MH  - Humans
MH  - *Illicit Drugs
MH  - Male
MH  - Middle Aged
MH  - Radiography, Abdominal/*methods
MH  - Sensitivity and Specificity
MH  - Supine Position
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2012/09/07 06:00
MHDA- 2013/02/12 06:00
CRDT- 2012/09/07 06:00
PHST- 2012/09/07 06:00 [entrez]
PHST- 2012/09/07 06:00 [pubmed]
PHST- 2013/02/12 06:00 [medline]
AID - radiol.12112767 [pii]
AID - 10.1148/radiol.12112767 [doi]
PST - ppublish
SO  - Radiology. 2012 Dec;265(3):772-9. doi: 10.1148/radiol.12112767. Epub 2012 Sep 5.


PMID- 22952383
OWN - NLM
STAT- MEDLINE
DCOM- 20130103
LR  - 20220316
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 265
IP  - 2
DP  - 2012 Nov
TI  - Hyperpolarized 3He and 129Xe MR imaging in healthy volunteers and patients with
      chronic obstructive pulmonary disease.
PG  - 600-10
LID - 10.1148/radiol.12120485 [doi]
AB  - PURPOSE: To quantitatively compare hyperpolarized helium 3 (3He) and xenon 129
      (129Xe) magnetic resonance (MR) images obtained within 5 minutes in healthy
      volunteers and patients with chronic obstructive pulmonary disease (COPD) and to 
      evaluate the correlations between 3He and 129Xe MR imaging measurements and those
      from spirometry and plethysmography. MATERIALS AND METHODS: This study was
      approved by an ethics board and compliant with HIPAA. Written informed consent
      was obtained from all subjects. Eight healthy volunteers and 10 patients with
      COPD underwent MR imaging, spirometry, and plethysmography. Ventilation defect
      percentages (VDPs) at 3He and 129Xe imaging were obtained by using semiautomated 
      segmentation. Apparent diffusion coefficients (ADCs) were calculated from 3He
      (b=1.6 sec/cm2) and 129Xe (b=12 sec/cm2) diffusion-weighted images. VDPs at
      hyperpolarized 3He and 129Xe imaging were compared with a two-tailed Wilcoxon
      signed rank test and analysis of variance; Pearson correlation coefficients were 
      used to evaluate the relationships among measurements. RESULTS: 129Xe VDP was
      significantly greater than 3He VDP for patients with COPD (P<.0001) but not for
      healthy volunteers (P=.35), although 3He and 129Xe VDPs showed a significant
      correlation for all subjects (r=0.91, P<.0001). The forced expiratory volume in 1
      second (FEV1) showed a similar and significant correlation with 3He VDP (r=-0.84,
      P<.0001) and 129Xe VDP (r=-0.89, P<.0001), although the correlation between the
      FEV1/forced vital capacity (FVC) ratio and 129Xe VDP (r=-0.95, P<.0001) was
      significantly greater (P=.01) than that for FEV1/FVC and 3He VDP (r=-0.84,
      P<.0001). A significant correlation was also observed for 3He and 129Xe ADC
      (r=0.97, P<.0001); 129Xe ADC was significantly correlated with diffusing capacity
      of lung for carbon monoxide (r=-0.79, P=.03) and computed tomographic emphysema
      measurements (areas with attenuation values in the 15th percentile: r=-0.91,
      P=.0003; relative areas with attenuation values of less than -950 HU: r=0.87,
      P=.001). CONCLUSION: In patients with COPD, the VDP obtained with hyperpolarized 
      29Xe MR imaging was significantly greater than that with 3He MR imaging,
      suggesting incomplete or delayed filling of lung regions that may be related to
      the different properties of 129Xe gas and physiologic and/or anatomic
      abnormalities in COPD.
CI  - (c) RSNA, 2012
FAU - Kirby, Miranda
AU  - Kirby M
AD  - Imaging Research Laboratories, Robarts Research Institute, 100 Perth Dr, London, 
      ON, Canada N6A 5K8.
FAU - Svenningsen, Sarah
AU  - Svenningsen S
FAU - Owrangi, Amir
AU  - Owrangi A
FAU - Wheatley, Andrew
AU  - Wheatley A
FAU - Farag, Adam
AU  - Farag A
FAU - Ouriadov, Alexei
AU  - Ouriadov A
FAU - Santyr, Giles E
AU  - Santyr GE
FAU - Etemad-Rezai, Roya
AU  - Etemad-Rezai R
FAU - Coxson, Harvey O
AU  - Coxson HO
FAU - McCormack, David G
AU  - McCormack DG
FAU - Parraga, Grace
AU  - Parraga G
LA  - eng
GR  - MOP 106437/Canadian Institutes of Health Research/Canada
GR  - MOP 97748/Canadian Institutes of Health Research/Canada
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120905
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Aerosols)
RN  - 0 (Contrast Media)
RN  - 0 (Isotopes)
RN  - 0 (Xenon Isotopes)
RN  - 206GF3GB41 (Helium)
SB  - IM
MH  - Administration, Inhalation
MH  - Aerosols/administration & dosage
MH  - Aged
MH  - Contrast Media
MH  - Female
MH  - Helium/*administration & dosage
MH  - Humans
MH  - Isotopes
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Pulmonary Disease, Chronic Obstructive/*diagnosis
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Static Electricity
MH  - Xenon Isotopes/*administration & dosage
EDAT- 2012/09/07 06:00
MHDA- 2013/01/04 06:00
CRDT- 2012/09/07 06:00
PHST- 2012/09/07 06:00 [entrez]
PHST- 2012/09/07 06:00 [pubmed]
PHST- 2013/01/04 06:00 [medline]
AID - radiol.12120485 [pii]
AID - 10.1148/radiol.12120485 [doi]
PST - ppublish
SO  - Radiology. 2012 Nov;265(2):600-10. doi: 10.1148/radiol.12120485. Epub 2012 Sep 5.


PMID- 22952333
OWN - NLM
STAT- MEDLINE
DCOM- 20150414
LR  - 20211021
IS  - 1592-8721 (Electronic)
IS  - 0390-6078 (Linking)
VI  - 97
IP  - 9
DP  - 2012 Sep
TI  - Ethical concerns surrounding the conception of an HLA compatible child for
      medical purposes.
PG  - e33; author reply e36
LID - 10.3324/haematol.2012.068015 [doi]
FAU - Pisu, Salvatore
AU  - Pisu S
FAU - Demuru, Federica
AU  - Demuru F
FAU - Caocci, Giovanni
AU  - Caocci G
FAU - La Nasa, Giorgio
AU  - La Nasa G
LA  - eng
PT  - Letter
PT  - Comment
PL  - Italy
TA  - Haematologica
JT  - Haematologica
JID - 0417435
SB  - IM
CON - Haematologica. 2012 Apr;97(4):479-81. PMID: 22492290
MH  - Female
MH  - Hematopoietic Stem Cell Transplantation/*ethics
MH  - Humans
MH  - Male
MH  - Pregnancy
MH  - Tissue Donors/*ethics
PMC - PMC3436224
EDAT- 2012/09/07 06:00
MHDA- 2015/04/15 06:00
CRDT- 2012/09/07 06:00
PHST- 2012/09/07 06:00 [entrez]
PHST- 2012/09/07 06:00 [pubmed]
PHST- 2015/04/15 06:00 [medline]
AID - haematol.2012.068015 [pii]
AID - 10.3324/haematol.2012.068015 [doi]
PST - ppublish
SO  - Haematologica. 2012 Sep;97(9):e33; author reply e36. doi:
      10.3324/haematol.2012.068015.


PMID- 22952319
OWN - NLM
STAT- MEDLINE
DCOM- 20130506
LR  - 20211021
IS  - 1940-5200 (Electronic)
IS  - 1078-3458 (Linking)
VI  - 18
IP  - 4
DP  - 2012 Oct
TI  - Ethical challenges in conducting HIV/AIDS research in correctional settings.
PG  - 309-18
LID - 10.1177/1078345812456194 [doi]
AB  - To explore ethical challenges in the conduct and oversight of HIV/AIDS research
      in correctional settings, 92 researchers; IRB chairs, members, and prisoner
      representatives; research ethicists; and prison administrators were asked the
      question, "If you had to pick the single most important ethical challenge to
      HIV/AIDS research with incarcerated people, what would it be?" Data were analyzed
      with NVivo 8.0 software and revealed that key concerns were confidentiality and
      privacy; autonomy and informed consent; and justice and access. Characteristics
      of people who are incarcerated, the nature of correctional institutions, and
      state and federal regulatory issues contributed to these challenges. These
      findings provide insights into ethical challenges that affect the conduct of
      HIV/AIDS research in correctional settings.
FAU - Eldridge, Gloria D
AU  - Eldridge GD
AD  - Center for Behavioral Health Research and Services, University of Alaska,
      Anchorage, AK 99508, USA.
FAU - Robinson, Rebecca Volino
AU  - Robinson RV
FAU - Corey, Staci
AU  - Corey S
FAU - Brems, Christiane
AU  - Brems C
FAU - Johnson, Mark E
AU  - Johnson ME
LA  - eng
GR  - R01 DA020357/DA/NIDA NIH HHS/United States
GR  - R01DA020357/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20120905
PL  - United States
TA  - J Correct Health Care
JT  - Journal of correctional health care : the official journal of the National
      Commission on Correctional Health Care
JID - 9503759
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/therapy
MH  - Adult
MH  - Biomedical Research/*ethics
MH  - Confidentiality
MH  - Female
MH  - HIV Infections/*therapy
MH  - Humans
MH  - Informed Consent
MH  - Male
MH  - Middle Aged
MH  - Personal Autonomy
MH  - *Prisons
EDAT- 2012/09/07 06:00
MHDA- 2013/05/07 06:00
CRDT- 2012/09/07 06:00
PHST- 2012/09/07 06:00 [entrez]
PHST- 2012/09/07 06:00 [pubmed]
PHST- 2013/05/07 06:00 [medline]
AID - 1078345812456194 [pii]
AID - 10.1177/1078345812456194 [doi]
PST - ppublish
SO  - J Correct Health Care. 2012 Oct;18(4):309-18. doi: 10.1177/1078345812456194. Epub
      2012 Sep 5.


PMID- 22952256
OWN - NLM
STAT- MEDLINE
DCOM- 20130114
LR  - 20120906
IS  - 1522-1229 (Electronic)
IS  - 1043-4046 (Linking)
VI  - 36
IP  - 3
DP  - 2012 Sep
TI  - Assessing formal teaching of ethics in physiology: an empirical survey, patterns,
      and recommendations.
PG  - 188-91
LID - 10.1152/advan.00010.2012 [doi]
AB  - Ethics should be an important component of physiological education. In this
      report, we examined to what extent teaching of ethics is formally being
      incorporated into the physiology curriculum. We carried out an e-mail survey in
      which we asked the e-mail recipients whether their institution offered a course
      or lecture on ethics as part of the physiology teaching process at their
      institution, using the following query: "We are now doing an online survey in
      which we would like to know whether you offer a course or a lecture on ethics as 
      part of your physiology teaching curriculum." The response rate was 53.3%: we
      received 104 responses of a total of 195 sent out. Our responses came from 45
      countries. While all of our responders confirmed that there was a need for ethics
      during medical education and scientific training, the degree of inclusion of
      formal ethics in the physiology curriculum varied widely. Our survey showed that,
      in most cases (69%), including at our Medical University of Graz, ethics in
      physiology is not incorporated into the physiology curriculum. Given this result,
      we suggest specific topics related to ethics and ethical considerations that
      could be integrated into the physiology curriculum. We present here a template
      example of a lecture "Teaching Ethics in Physiology" (structure, content,
      examples, and references), which was based on guidelines and case reports
      provided by experts in this area (e.g., Benos DJ. Ethics revisited. Adv Physiol
      Educ 25: 189-190, 2001). This lecture, which we are presently using in Graz,
      could be used as a base that could lead to greater awareness of important ethical
      issues in students at an early point in the educational process.
FAU - Goswami, Nandu
AU  - Goswami N
AD  - Institute of Physiology, Center of Physiological Medicine, Medical University of 
      Graz, Graz, Austria. nandu.goswami@medunigraz.at
FAU - Batzel, Jerry Joseph
AU  - Batzel JJ
FAU - Hinghofer-Szalkay, Helmut
AU  - Hinghofer-Szalkay H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Adv Physiol Educ
JT  - Advances in physiology education
JID - 100913944
SB  - IM
MH  - Curriculum
MH  - Empirical Research
MH  - *Ethics
MH  - Physiology/*education
EDAT- 2012/09/07 06:00
MHDA- 2013/01/15 06:00
CRDT- 2012/09/07 06:00
PHST- 2012/09/07 06:00 [entrez]
PHST- 2012/09/07 06:00 [pubmed]
PHST- 2013/01/15 06:00 [medline]
AID - 36/3/188 [pii]
AID - 10.1152/advan.00010.2012 [doi]
PST - ppublish
SO  - Adv Physiol Educ. 2012 Sep;36(3):188-91. doi: 10.1152/advan.00010.2012.


PMID- 22952165
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130101
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 5
DP  - 2012
TI  - Lung Injury Prevention with Aspirin (LIPS-A): a protocol for a multicentre
      randomised clinical trial in medical patients at high risk of acute lung injury.
LID - 10.1136/bmjopen-2012-001606 [doi]
LID - e001606 [pii]
AB  - INTRODUCTION: Acute lung injury (ALI) is a devastating condition that places a
      heavy burden on public health resources. Although the need for effective ALI
      prevention strategies is increasingly recognised, no effective preventative
      strategies exist. The Lung Injury Prevention Study with Aspirin (LIPS-A) aims to 
      test whether aspirin (ASA) could prevent and/or mitigate the development of ALI. 
      METHODS AND ANALYSIS: LIPS-A is a multicentre, double-blind, randomised clinical 
      trial testing the hypothesis that the early administration of ASA will result in 
      a reduced incidence of ALI in adult patients at high risk. This investigation
      will enrol 400 study participants from 14 hospitals across the USA. Conditional
      logistic regression will be used to test the primary hypothesis that early ASA
      administration will decrease the incidence of ALI. ETHICS AND DISSEMINATION:
      Safety oversight will be under the direction of an independent Data and Safety
      Monitoring Board (DSMB). Approval of the protocol was obtained from the DSMB
      prior to enrolling the first study participant. Approval of both the protocol and
      informed consent documents were also obtained from the institutional review board
      of each participating institution prior to enrolling study participants at the
      respective site. In addition to providing important clinical and mechanistic
      information, this investigation will inform the scientific merit and feasibility 
      of a phase III trial on ASA as an ALI prevention agent. The findings of this
      investigation, as well as associated ancillary studies, will be disseminated in
      the form of oral and abstract presentations at major national and international
      medical specialty meetings. The primary objective and other significant findings 
      will also be presented in manuscript form. All final, published manuscripts
      resulting from this protocol will be submitted to Pub Med Central in accordance
      with the National Institute of Health Public Access Policy.
FAU - Kor, Daryl Jon
AU  - Kor DJ
AD  - Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester,
      Minnesota, USA.
FAU - Talmor, Daniel S
AU  - Talmor DS
FAU - Banner-Goodspeed, Valerie M
AU  - Banner-Goodspeed VM
FAU - Carter, Rickey E
AU  - Carter RE
FAU - Hinds, Richard
AU  - Hinds R
FAU - Park, Pauline K
AU  - Park PK
FAU - Gajic, Ognjen
AU  - Gajic O
FAU - Gong, Michelle N
AU  - Gong MN
CN  - US Critical Illness and Injury Trials Group: Lung Injury Prevention with Aspirin 
      Study Group (USCIITG: LIPS-A)
LA  - eng
GR  - KL2 RR024151/RR/NCRR NIH HHS/United States
GR  - U01 HL108712/HL/NHLBI NIH HHS/United States
PT  - Journal Article
DEP - 20120904
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3437429
EDAT- 2012/09/07 06:00
MHDA- 2012/09/07 06:01
CRDT- 2012/09/07 06:00
PHST- 2012/09/07 06:00 [entrez]
PHST- 2012/09/07 06:00 [pubmed]
PHST- 2012/09/07 06:01 [medline]
AID - bmjopen-2012-001606 [pii]
AID - 10.1136/bmjopen-2012-001606 [doi]
PST - epublish
SO  - BMJ Open. 2012 Sep 4;2(5). pii: bmjopen-2012-001606. doi:
      10.1136/bmjopen-2012-001606. Print 2012.


PMID- 22951656
OWN - NLM
STAT- MEDLINE
DCOM- 20130725
LR  - 20120906
IS  - 0374-9096 (Print)
IS  - 0374-9096 (Linking)
VI  - 46
IP  - 3
DP  - 2012 Jul
TI  - [Investigation of combined effectiveness of spiramycin and beta-glucan in mice
      models of acute toxoplasmosis and determination of IL-10, IL-12 and TNF-alpha
      levels].
PG  - 446-55
AB  - Toxoplasmosis which is caused by Toxoplasma gondii, has a high risk of fetal
      infection development if the infection occurs during pregnancy. Treatment with
      oral spiramycin is recommended during pregnancy in order to prevent the
      transmission of protozoa to fetus and development of infection. Since beta-
      glucan is known to stimulate the immune system and increase the phagocytic
      activity of the cells, it has been shown to exhibit immunomodulatory effect on
      many infectious diseases. The objectives of this study were to investigate the
      effectiveness of beta-glucan alone and in combination with spiramycin and to
      determinate the levels of interlokin (IL)-10, IL-12 and tumor nekrosis factor
      (TNF)-alpha in mice experimentally infected with T.gondii. For this purpose, four
      experimental groups each consisting of eight BALB/c mice, were formed with the
      approval of Ethics Committee for the Animal Experiments. All the mice were
      infected with 2 ml of suspension containing 2 x 102/ml of trophozoite prepared
      from T.gondii RH strain (Refik Saydam National Public Health Agency, Parasitology
      Laboratory of Communicable Diseases Research Department, Ankara, Turkey), by
      intraperitoneal injection. Twenty-four hours after the infection, beta-glucan (3 
      mg/day) was given to the beta-glucan group, spiramycin (200 mg/kg/day) to the
      spiramycin group, beta-glucan (3 mg/day) plus spiramycin (200 mg/kg/day) to the
      beta-glucan-spiramycin (BG-S) group by oral gavage. The fourth group which was
      the control group was infected but untreated. The above administration was
      carried out for seven days. On the 8th day, under anaesthesia, 1 ml normal saline
      was given into the peritoneum, drawn back later and the number of trophozoites in
      1 ml of peritoneal fluid was determined by counting them on the Thoma slide.
      Moreover, by drawing the heart blood; IL-10, IL-12, TNF-alpha levels were
      determined in serum samples by ELISA method (eBioscience Platinum, Austria). The 
      number of trophozoites in the BG-S group was found significantly lower than the
      number of trophozoites in control, beta-glucan and spiramycin groups (p< 0.05).
      There was no significant difference between the beta-glucan and spiramycin
      groups, however the number of trophozoites in both groups was significantly lower
      than the number of trophozoites in the control group (p< 0.05). There was a
      certain decrease in IL-10 level in spiramycin and BG-S groups, compared to the
      control group, in addition when IL-10 levels in spiramycin and BG-S groups were
      compared with BG group, a significant decrease was noticed (p< 0.05). There was
      no difference in IL-12 levels between the groups, while there was a certain
      decrease in TNF-alpha level in beta-glucan, spiramycin, BG-S group in comparison 
      to the control group. Within the reach of our literature survey, this study is
      the first research in which the effectiveness of the combination of beta-glucan
      and spiramycin in the treatment of acute toxoplasmosis was investigated. The
      results of our study suggested that there might be synergy between beta-glucan
      and spiramycin in the treatment of acute toxoplasmosis.
FAU - Buyukbaba Boral, Ozden
AU  - Buyukbaba Boral O
AD  - Istanbul University Faculty of Istanbul Medicine, Department of Medical
      Microbiology, Istanbul, Turkey. obboral@yahoo.com
FAU - Sonmez Tamer, Gulden
AU  - Sonmez Tamer G
FAU - Keceli Ozcan, Sema
AU  - Keceli Ozcan S
FAU - Sonmez, Nese
AU  - Sonmez N
FAU - Issever, Halim
AU  - Issever H
FAU - Tekeli, Fatma
AU  - Tekeli F
LA  - tur
PT  - English Abstract
PT  - Journal Article
TT  - Spiramisin ve Beta-Glukan Kombinasyonu Etkinliginin Akut Toksoplazmozlu Fare
      Modelinde Arastirilmasi ve IL-10, IL-12 ve TNF-alpha Duzeylerinin Belirlenmesi.
PL  - Turkey
TA  - Mikrobiyol Bul
JT  - Mikrobiyoloji bulteni
JID - 7503830
RN  - 0 (Coccidiostats)
RN  - 0 (Cytokines)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (beta-Glucans)
RN  - 130068-27-8 (Interleukin-10)
RN  - 187348-17-0 (Interleukin-12)
RN  - 8025-81-8 (Spiramycin)
SB  - IM
MH  - Acute Disease
MH  - Animals
MH  - Coccidiostats/*therapeutic use
MH  - Cytokines/*blood
MH  - Drug Therapy, Combination
MH  - Female
MH  - Interleukin-10/blood
MH  - Interleukin-12/blood
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Spiramycin/*therapeutic use
MH  - Toxoplasmosis, Animal/*drug therapy/immunology
MH  - Tumor Necrosis Factor-alpha/blood
MH  - beta-Glucans/*therapeutic use
EDAT- 2012/09/07 06:00
MHDA- 2013/07/26 06:00
CRDT- 2012/09/07 06:00
PHST- 2012/09/07 06:00 [entrez]
PHST- 2012/09/07 06:00 [pubmed]
PHST- 2013/07/26 06:00 [medline]
PST - ppublish
SO  - Mikrobiyol Bul. 2012 Jul;46(3):446-55.


PMID- 22951411
OWN - NLM
STAT- MEDLINE
DCOM- 20121120
LR  - 20120906
IS  - 0030-6002 (Print)
IS  - 0030-6002 (Linking)
VI  - 153
IP  - 36
DP  - 2012 Sep 9
TI  - [Market oriented occupational medicine].
PG  - 1433-9
LID - 10.1556/OH.2012.29426 [doi]
AB  - The history and the recent state of occupational medicine in Hungary, and its
      relation with governmental labor organizations are analyzed. In the past 20
      years, large "socialist" factories were replaced by smaller companies employing
      fewer workers. They have been forced to establish contract with occupational
      health providers. Many of them offer primary care services, whereas family
      physicians having a board examination in occupational medicine are allowed to
      work in this field as well. The market of occupational medicine is less
      regulated, and ethical rules are not always considered. Undercutting prices is a 
      common practice. The recent system could be improved by some regulations which
      should be respected. There is no reason to make rough changes establishing a new 
      market for profit oriented insurance companies, and to allow employees and
      employers to work without specification neglecting international agreements.
      Occupational medicine should be supervised again by the health authorities
      instead of economists who have quite different, short-term priorities.
FAU - Rurik, Imre
AU  - Rurik I
AD  - Debreceni Egyetem, Orvos- es Egeszsegtudomanyi Centrum, Nepegeszsegugyi Kar
      Csaladorvosi es Foglalkozas-egeszsegugyi Tanszek Debrecen Moricz Zs. krt. 22.
      4032. Rurik.Imre@sph.unideb.hu
FAU - Cseh, Karoly
AU  - Cseh K
LA  - hun
PT  - English Abstract
PT  - Journal Article
TT  - Piaci viszonyok a foglalkozas-egeszsegugyben.
PL  - Hungary
TA  - Orv Hetil
JT  - Orvosi hetilap
JID - 0376412
SB  - IM
MH  - *Commerce
MH  - Health Care Sector/economics/legislation & jurisprudence/*trends
MH  - Humans
MH  - Hungary
MH  - Insurance Carriers/economics/legislation & jurisprudence/trends
MH  - *Insurance, Health/economics/legislation & jurisprudence/trends
MH  - *Occupational Health/economics/trends
MH  - *Occupational Medicine/economics/legislation & jurisprudence/standards/trends
MH  - Primary Health Care/economics/trends
MH  - Public Health/economics/trends
EDAT- 2012/09/07 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/09/07 06:00
PHST- 2012/09/07 06:00 [entrez]
PHST- 2012/09/07 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 3221L70W92563648 [pii]
AID - 10.1556/OH.2012.29426 [doi]
PST - ppublish
SO  - Orv Hetil. 2012 Sep 9;153(36):1433-9. doi: 10.1556/OH.2012.29426.


PMID- 22951200
OWN - NLM
STAT- MEDLINE
DCOM- 20130319
LR  - 20180813
IS  - 2245-1919 (Electronic)
IS  - 2245-1919 (Linking)
VI  - 59
IP  - 9
DP  - 2012 Sep
TI  - Vitamin D deficiency is unrelated to type of atrial fibrillation and its
      complications.
PG  - A4505
AB  - INTRODUCTION: Vitamin D plays an important role in a broad range of organ
      functions, including the cardiovascular system. Only one study has tested the
      association between vitamin D deficiency and arrhythmia and it found no
      association. The aim of the present study was to evaluate the association between
      vitamin D deficiency and the type of atrial fibrillation (AF) and complications
      to AF. MATERIAL AND METHODS: In total, 258 patients were consecutively included
      from March 2009 to February 2011. All in- and out-patients in the Department of
      Cardiology at Hvidovre Hospital were invited to participate, provided they had
      electrocardiographically documented AF. Patients with dementia or terminal
      illness were excluded. 25 hydroxyvitamin D (25 OHD) was measured with a
      chemiluminescence assay (Liaison from DiaSorin, Stillwater, Minnesota, USA).
      RESULTS: No association between vitamin D level and type of AF was found.
      Furthermore, no association between vitamin D deficiency and ischaemic heart
      disease, stroke or acute myocardial infarction was found. Vitamin D deficiency
      was significantly associated with low age (p = 0.02) and gender with a higher
      proportion of females having the optimal level of 25 OHD (p = 0.0005).
      CONCLUSION: Other studies have found a beneficial effect of vitamin D on
      cardiovascular diseases, but we found no association between vitamin D deficiency
      and the type of AF or complications to AF. Further investigation is necessary to 
      determine whether vitamin D supplementation improves cardiovascular outcomes in
      patients with AF. FUNDING: The study has received financial support from several 
      private and one public fund. TRIAL REGISTRATION: The study was approved by the
      National Ethics Committee (Project-ID: H-C-2009-014).
FAU - Qayyum, Faiza
AU  - Qayyum F
AD  - Department of Cardiology, Hvidovre Hospital.
FAU - Landex, Nadia Lander
AU  - Landex NL
FAU - Agner, Bue Ross
AU  - Agner BR
FAU - Rasmussen, Michella
AU  - Rasmussen M
FAU - Jons, Christian
AU  - Jons C
FAU - Dixen, Ulrik
AU  - Dixen U
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Dan Med J
JT  - Danish medical journal
JID - 101576205
RN  - 1406-16-2 (Vitamin D)
RN  - A288AR3C9H (25-hydroxyvitamin D)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Atrial Fibrillation/*classification/*complications
MH  - Chi-Square Distribution
MH  - Electrocardiography
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/blood/complications
MH  - Sex Factors
MH  - Stroke/blood/complications
MH  - Vitamin D/analogs & derivatives/blood
MH  - Vitamin D Deficiency/blood/*complications
EDAT- 2012/09/07 06:00
MHDA- 2013/03/21 06:00
CRDT- 2012/09/07 06:00
PHST- 2012/09/07 06:00 [entrez]
PHST- 2012/09/07 06:00 [pubmed]
PHST- 2013/03/21 06:00 [medline]
AID - A4505 [pii]
PST - ppublish
SO  - Dan Med J. 2012 Sep;59(9):A4505.


PMID- 22951194
OWN - NLM
STAT- MEDLINE
DCOM- 20130319
LR  - 20161125
IS  - 2245-1919 (Electronic)
IS  - 2245-1919 (Linking)
VI  - 59
IP  - 9
DP  - 2012 Sep
TI  - Ileoscopy reduces the need for small bowel imaging in suspected Crohn's disease.
PG  - A4491
AB  - INTRODUCTION: In suspected Crohn's disease (CD), current diagnostic guidelines
      recommend additional small bowel imaging irrespective of the findings at
      ileocolonoscopy. Magnetic resonance imaging enterography (MRE) and computed
      tomography enterography (CTE) are regarded first line imaging techniques and
      should generally precede capsule endoscopy. MATERIAL AND METHODS: This article
      brings together results from a prospective blinded diagnostic study of MRE, CTE, 
      capsule endoscopy and faecal calprotectin (fCal) in 93 patients undergoing their 
      first diagnostic work-up for CD. RESULTS: In patients with suspected CD, fCal is 
      useful for the identification patients without need for colonoscopy or small
      bowel imaging. Patients with an elevated fCal should undergo colonoscopy
      including a persistent attempt to intubate the terminal ileum. CD isolated in the
      upper small bowel is rare, and in patients with a normal ileocolonoscopy or
      non-complicated CD in the colon and/or terminal ileum, small bowel imaging
      provides little extra information compared to ileoscopy alone. Small bowel
      imaging is primarily indicated if ileoscopy is not achieved and capsule endoscopy
      is recommended as first line imaging technique. If small bowel stenosis is not
      ruled out, a preceding test with a patency capsule can be performed to avoid
      capsule retention. MRE and CTE are complimentary modalities preferably used in
      patients with stenosis detected at ileocolonoscopy or suspicion of
      extra-intestinal disease complications. CONCLUSION: Our results suggest that a
      diagnostic approach different to that described in the guidelines may be
      expedient. FUNDING: not relevant. TRIAL REGISTRATION: The study was approved by
      the Ethics Committee of Southern Denmark (S-20070072) and the Danish Data
      Protection Agency (journal number: 2007-41-0675). ClinicalTrials.gov identifier: 
      NCT01019460.
FAU - Jensen, Michael Dam
AU  - Jensen MD
AD  - Afdeling for Intern Medicin, Gastroenterologisk Afdeling, Sygehus Lillebaelt,
      Vejle Sygehus, Kabbeltoft 25, 7100 Vejle, Denmark.
      michael.dam.jensen@slb.regionsyddanmark.dk
FAU - Nathan, Torben
AU  - Nathan T
FAU - Rafaelsen, Soren Rafael
AU  - Rafaelsen SR
FAU - Kjeldsen, Jens
AU  - Kjeldsen J
LA  - eng
SI  - ClinicalTrials.gov/NCT01019460
PT  - Clinical Trial
PT  - Journal Article
PL  - Denmark
TA  - Dan Med J
JT  - Danish medical journal
JID - 101576205
RN  - 0 (Leukocyte L1 Antigen Complex)
SB  - IM
MH  - *Capsule Endoscopy
MH  - *Colonoscopy
MH  - Constriction, Pathologic/diagnosis/etiology
MH  - Crohn Disease/*diagnosis/diagnostic imaging
MH  - Feces/chemistry
MH  - Humans
MH  - Ileum/diagnostic imaging/pathology
MH  - Leukocyte L1 Antigen Complex/*analysis
MH  - *Magnetic Resonance Imaging
MH  - Sensitivity and Specificity
MH  - *Tomography, X-Ray Computed
EDAT- 2012/09/07 06:00
MHDA- 2013/03/21 06:00
CRDT- 2012/09/07 06:00
PHST- 2012/09/07 06:00 [entrez]
PHST- 2012/09/07 06:00 [pubmed]
PHST- 2013/03/21 06:00 [medline]
AID - A4491 [pii]
PST - ppublish
SO  - Dan Med J. 2012 Sep;59(9):A4491.


PMID- 22950732
OWN - NLM
STAT- MEDLINE
DCOM- 20121105
LR  - 20120906
IS  - 1466-769X (Electronic)
IS  - 1466-7681 (Linking)
VI  - 13
IP  - 4
DP  - 2012 Oct
TI  - Phenomenology, ethics, and the crisis of the lived-body.
PG  - 289-94
LID - 10.1111/j.1466-769X.2011.00533.x [doi]
FAU - Murray, Stuart J
AU  - Murray SJ
AD  - Department of English Language & Literature, Carleton University, Ottawa, ON,
      Canada. stuart_murray@carleton.ca
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nurs Philos
JT  - Nursing philosophy : an international journal for healthcare professionals
JID - 100897394
SB  - IM
MH  - *Bioethical Issues
MH  - *Ethics, Nursing
MH  - Humans
MH  - Nursing Research
MH  - *Philosophy, Nursing
EDAT- 2012/09/07 06:00
MHDA- 2012/11/06 06:00
CRDT- 2012/09/07 06:00
PHST- 2012/09/07 06:00 [entrez]
PHST- 2012/09/07 06:00 [pubmed]
PHST- 2012/11/06 06:00 [medline]
AID - 10.1111/j.1466-769X.2011.00533.x [doi]
PST - ppublish
SO  - Nurs Philos. 2012 Oct;13(4):289-94. doi: 10.1111/j.1466-769X.2011.00533.x.


PMID- 22950730
OWN - NLM
STAT- MEDLINE
DCOM- 20121105
LR  - 20120906
IS  - 1466-769X (Electronic)
IS  - 1466-7681 (Linking)
VI  - 13
IP  - 4
DP  - 2012 Oct
TI  - Furthering the sceptical case against virtue ethics in nursing ethics.
PG  - 266-75
LID - 10.1111/j.1466-769X.2012.00541.x [doi]
AB  - In a recent article in this journal I presented a sceptical argument about the
      current prominence of virtue ethics in nursing ethics. Daniel Putman has
      responded with a defence of the relevance of virtue in nursing. The present
      article continues this discussion by clarifying, defending, and expanding the
      sceptical argument. I start by emphasizing some features of the sceptical case,
      including assumptions about the nature of sceptical arguments, and about the
      character of both virtue ethics and nursing ethics. Then I respond to objections 
      of Putman's such as that, according to virtue ethics, virtue is relevant to the
      whole of a human life, including one's behaviour in a professional context; and
      that eudaimonia should be central in explaining and motivating a nurse's decision
      to enter the profession. Having argued that these objections are not compelling, 
      I go on to discuss an interesting recent attempt to reassert the role of virtue
      ethics in the ethics of professions, including nursing. This centres on whether
      role-specific obligations - e.g. the obligations that arise for a moral agent qua
      lawyer or mother - can be accommodated in a virtue ethics approach. Sean Cordell 
      has argued that the difficulty of accommodating role-specific obligations results
      in an 'institution-shaped gap' in virtue ethics. He suggests a way of meeting
      this difficulty that appeals to the ergon of institutions. I endorse the negative
      point that role-specific obligations elude virtue ethics, but argue that the
      appeal to the ergon of institutions is unsuccessful. The upshot is further
      support for scepticism about the virtue ethics approach to nursing ethics. I end 
      by gesturing to some of the advantages of a sceptical view of virtue ethics in
      nursing ethics.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Holland, Stephen
AU  - Holland S
AD  - Philosophy Department, University of York, York, UK. stephen.holland@york.ac.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Philos
JT  - Nursing philosophy : an international journal for healthcare professionals
JID - 100897394
SB  - IM
MH  - *Ethics, Nursing
MH  - Humans
MH  - Moral Obligations
MH  - Nurse's Role
MH  - *Philosophy, Nursing
MH  - *Virtues
EDAT- 2012/09/07 06:00
MHDA- 2012/11/06 06:00
CRDT- 2012/09/07 06:00
PHST- 2012/09/07 06:00 [entrez]
PHST- 2012/09/07 06:00 [pubmed]
PHST- 2012/11/06 06:00 [medline]
AID - 10.1111/j.1466-769X.2012.00541.x [doi]
PST - ppublish
SO  - Nurs Philos. 2012 Oct;13(4):266-75. doi: 10.1111/j.1466-769X.2012.00541.x.


PMID- 22950727
OWN - NLM
STAT- MEDLINE
DCOM- 20121105
LR  - 20220408
IS  - 1466-769X (Electronic)
IS  - 1466-7681 (Linking)
VI  - 13
IP  - 4
DP  - 2012 Oct
TI  - The excesses of care: a matter of understanding the asymmetry of power.
PG  - 236-43
LID - 10.1111/j.1466-769X.2012.00537.x [doi]
AB  - The aim of the article is to illustrate concrete problems in the asymmetrical
      nurse-patient power relationship. It is an ethical demand that the nurse is faced
      with the challenges that the power in the relation is administered so that the
      patient's room for action is expanded and trust maintained. It is an essential
      message in care philosophy, but in clinical practice, success is not always
      achievable. A hidden and more or less unconscious restriction of the patient's
      room for action may result in the excesses of care. Three selected aspects:
      dependence, trust, and power described by the Danish philosopher K.E. Logstrup
      and the Norwegian nursing philosopher Kari Martinsen's care philosophy has
      inspired this empirically based examination of some current barriers in the
      asymmetrical nurse-patient relationship. On the basis of qualitative interviews
      with six patients and six nurses, the research thus provides an identifying and
      problem-exploratory examination of some current obstacles in which the handling
      of trust and power reflects the excesses of care. The findings develop three
      themes. 'Being a burden' acknowledges that the balance of power will always tip
      to the nurse's advantage. The second theme, 'Doing only what's absolutely
      necessary', shows how a fixation with 'technicalism' creates a distance between
      people that may constrain the patient's room for action. The last theme is
      concerning the nurse's ability to navigate between closeness and distance is
      essential in avoiding 'the excesses of care', paternalism, and
      overprotectiveness. A situation in which distance takes the upper hand and care
      turns into paternalism. A different situation would arise if the nurse's emotions
      became sentimental or intimate with the result that closeness gets the upper
      hand. To avoid a harmful exercise of power and the excesses of care, the findings
      have demonstrated that a relationship-based caring is a demand for
      situation-specific sensitive attention skills.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Delmar, Charlotte
AU  - Delmar C
AD  - Department of Nursing Science, School of Public Health & Institute of Clinical
      Medicine, Aarhus University, Denmark. cd@sygeplejevid.au.dk
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Philos
JT  - Nursing philosophy : an international journal for healthcare professionals
JID - 100897394
SB  - IM
MH  - Empathy/*ethics
MH  - Humans
MH  - Nurse-Patient Relations/*ethics
MH  - Paternalism/ethics
MH  - Philosophy, Nursing
MH  - *Power, Psychological
MH  - Trust/psychology
EDAT- 2012/09/07 06:00
MHDA- 2012/11/06 06:00
CRDT- 2012/09/07 06:00
PHST- 2012/09/07 06:00 [entrez]
PHST- 2012/09/07 06:00 [pubmed]
PHST- 2012/11/06 06:00 [medline]
AID - 10.1111/j.1466-769X.2012.00537.x [doi]
PST - ppublish
SO  - Nurs Philos. 2012 Oct;13(4):236-43. doi: 10.1111/j.1466-769X.2012.00537.x.


PMID- 22950430
OWN - NLM
STAT- MEDLINE
DCOM- 20130911
LR  - 20130118
IS  - 1557-8577 (Electronic)
IS  - 1549-1684 (Linking)
VI  - 15
IP  - 6
DP  - 2012 Dec
TI  - Estrogen replacement therapy improves pulmonary function in postmenopausal women 
      with genital prolapse.
PG  - 596-600
LID - 10.1089/rej.2012.1337 [doi]
AB  - OBJECTIVE: This study examined the impact of estrogen replacement therapy with
      spirometry on pulmonary function in surgically castrated (salpingo-oophorectomy) 
      postmenopausal women with genital prolapse. METHODS: The study included 60
      postmenopausal women with pelvic organ prolapse. The study received institutional
      Ethics Committee approval, and all subjects signed an informed consent. Women
      were randomly divided into two groups of 30 subjects: Group 1 (n=30) was
      administered estrogen replacement with 1 mg of stradiol hemihydrate (1 mg/day)
      orally for 6 months, and group 2 (n=30) was not taking estrogen. Both groups were
      matched by age, height, body mass index, parity, and duration of postmenopause.
      All subjects were evaluated with spirometry initially and after 6 months. For
      statistical analysis, descriptive and analytical methods were used, based on data
      type and distribution. The mean and standard deviations were used as measures of 
      central tendency and variability. Categorical data were expressed as absolute and
      relative numbers (percentage). The t-test for independent samples (for comparison
      of groups) and t-test for dependent samples (for comparison of serial
      measurements in the same patients) were used. The analysis was performed using R 
      software ( www.r-project.org ), with the level of significance set at p<0.05.
      RESULTS: Analysis of spirometry parameters showed statistically significant
      differences between the estrogen users and the nonusers groups. CONCLUSION: The
      most important study result was the significantly improved lung respiratory
      function in postmenopausal women with genital prolapse after 6 months of taking
      estrogen, confirming that hormone replacement therapy should be recommended to
      postmenopausal women. The findings of our study suggest the need for further
      research into the effect of estrogen on pulmonary function.
FAU - Stipic, Ivica
AU  - Stipic I
AD  - Department of Gynecology and Obstetrics, University Hospital, 21000 Split,
      Croatia.
FAU - Polasek, Ozren
AU  - Polasek O
FAU - Vulic, Marko
AU  - Vulic M
FAU - Punda, Hrvoje
AU  - Punda H
FAU - Grandic, Leo
AU  - Grandic L
FAU - Strinic, Tomislav
AU  - Strinic T
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20121116
PL  - United States
TA  - Rejuvenation Res
JT  - Rejuvenation research
JID - 101213381
SB  - IM
MH  - Anthropometry
MH  - *Estrogen Replacement Therapy
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Pelvic Organ Prolapse/*physiopathology/*therapy
MH  - Postmenopause/*physiology
MH  - Respiratory Function Tests
MH  - Spirometry
EDAT- 2012/09/07 06:00
MHDA- 2013/09/12 06:00
CRDT- 2012/09/07 06:00
PHST- 2012/09/07 06:00 [entrez]
PHST- 2012/09/07 06:00 [pubmed]
PHST- 2013/09/12 06:00 [medline]
AID - 10.1089/rej.2012.1337 [doi]
PST - ppublish
SO  - Rejuvenation Res. 2012 Dec;15(6):596-600. doi: 10.1089/rej.2012.1337. Epub 2012
      Nov 16.


PMID- 22949977
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2005-7563 (Electronic)
IS  - 2005-6419 (Linking)
VI  - 63
IP  - 2
DP  - 2012 Aug
TI  - Perioperative effects of various anesthetic adjuvants with TIVA guided by
      bispectral index.
PG  - 113-9
LID - 10.4097/kjae.2012.63.2.113 [doi]
AB  - BACKGROUND: This prospective, randomized, double blinded, controlled study was
      designed to compare effects of intravenous co-administration of clonidine,
      magnesium, or ketamine on anesthetic consumption, intraoperative hemodynamics,
      postoperative analgesia and recovery indices during Bispectral Index (BIS) guided
      total intravenous anesthesia (TIVA). METHODS: After ethical committee approval
      and written informed consent, 120 adult patients ASA I and II scheduled for open 
      cholecystectomy were randomly assigned to one of 4 equal groups. Group CL
      received clonidine 3 microg/kg and maintained by 2 microg/kg/h. Group MG received
      magnesium sulphate 50 mg/kg and maintained by 8 mg/kg/h. Group KET received
      racemic ketamine 0.4 mg/kg and maintained by 0.2 mg/kg/h. Control group (CT)
      received the same volume of isotonic saline. Anesthesia was induced and
      maintained by fentanyl, propofol and rocuronium. Propofol infusion was adjusted
      to keep the BIS value between 45-55. Intraoperative hemodynamics, induction time,
      anesthetic consumption, recovery indices, and PACU discharge were recorded.
      RESULTS: Induction time, propofol requirements for induction and maintenance of
      anesthesia, intraoperative fentanyl and hemodynamic values were significantly
      lower with Groups CL and MG compared to Groups KET and CT (P < 0.05). Patients in
      Group MG showed significantly lower muscle relaxant consumption, delayed recovery
      and PACU discharge than other groups (P < 0.05). First, analgesic requirement was
      significantly longer and total postoperative analgesic consumption was
      significantly lower in the adjuvant groups versus Group CT (P < 0.05).
      CONCLUSIONS: Clonidine, magnesium, and ketamine can be useful adjuvant agents to 
      BIS-guided TIVA. Pharmacokinetic studies of such drug combinations were
      recommended to investigate their interaction.
FAU - Khafagy, Hanan F
AU  - Khafagy HF
AD  - Department of Anesthesiology, Theodor Bilharz Research Institute, Ministry of
      High Education and Scientific Research, Giza, Egypt.
FAU - Ebied, Reeham S
AU  - Ebied RS
FAU - Osman, Emad S
AU  - Osman ES
FAU - Ali, Mohamed Z
AU  - Ali MZ
FAU - Samhan, Yasser M
AU  - Samhan YM
LA  - eng
PT  - Journal Article
DEP - 20120814
PL  - Korea (South)
TA  - Korean J Anesthesiol
JT  - Korean journal of anesthesiology
JID - 101502451
PMC - PMC3427802
OTO - NOTNLM
OT  - BIS
OT  - Clonidine
OT  - Ketamine
OT  - Magnesium
OT  - TIVA
EDAT- 2012/09/06 06:00
MHDA- 2012/09/06 06:01
CRDT- 2012/09/06 06:00
PHST- 2011/11/01 00:00 [received]
PHST- 2012/03/09 00:00 [revised]
PHST- 2012/03/13 00:00 [accepted]
PHST- 2012/09/06 06:00 [entrez]
PHST- 2012/09/06 06:00 [pubmed]
PHST- 2012/09/06 06:01 [medline]
AID - 10.4097/kjae.2012.63.2.113 [doi]
PST - ppublish
SO  - Korean J Anesthesiol. 2012 Aug;63(2):113-9. doi: 10.4097/kjae.2012.63.2.113. Epub
      2012 Aug 14.


PMID- 22948844
OWN - NLM
STAT- MEDLINE
DCOM- 20150624
LR  - 20141103
IS  - 1520-6696 (Electronic)
IS  - 0022-5061 (Linking)
VI  - 48
IP  - 4
DP  - 2012 Fall
TI  - Japanese American wartime experience, Tamotsu Shibutani and methodological
      innovation, 1942-1978.
PG  - 318-38
LID - 10.1002/jhbs.21564 [doi]
AB  - A case study of how wartime internment reverberated in the life and work of
      Japanese American intellectuals, this essay discusses the career and interests of
      Tamotsu Shibutani, a sociologist who began his training as part of Dorothy Swaine
      Thomas' Japanese American Evacuation and Resettlement Study (JERS). Though recent
      scholarship has noted some of the ethical problems that attended the use of
      Japanese American participant observers during the war, this essay concentrates
      instead on how interned intellectuals responded to their double role of both
      researcher (and intellectual) and object of study. I argue that in the case of
      Shibutani, his circumstances and identity shaped his scholarship, both as an
      academic endeavor and a political project. By tracking Shibutani's postwar
      scholarly activities, I show that his wartime experiences--as an internee,
      military officer, and participant-observer--reverberated in his sociological
      publications long after the war's end.
CI  - (c) 2012 Wiley Periodicals, Inc.
FAU - Inouye, Karen M
AU  - Inouye KM
LA  - eng
PT  - Biography
PT  - Historical Article
PT  - Journal Article
DEP - 20120904
PL  - United States
TA  - J Hist Behav Sci
JT  - Journal of the history of the behavioral sciences
JID - 18020010R
SB  - IM
MH  - Asian Americans
MH  - Behavioral Sciences/*history
MH  - History, 20th Century
MH  - Humans
MH  - Research Personnel/*history
MH  - *World War II
PS  - Shibutani T
FPS - Shibutani, Tamotsu
EDAT- 2012/09/06 06:00
MHDA- 2015/06/25 06:00
CRDT- 2012/09/06 06:00
PHST- 2012/09/06 06:00 [entrez]
PHST- 2012/09/06 06:00 [pubmed]
PHST- 2015/06/25 06:00 [medline]
AID - 10.1002/jhbs.21564 [doi]
PST - ppublish
SO  - J Hist Behav Sci. 2012 Fall;48(4):318-38. doi: 10.1002/jhbs.21564. Epub 2012 Sep 
      4.


PMID- 22947883
OWN - NLM
STAT- MEDLINE
DCOM- 20130214
LR  - 20181201
IS  - 1536-7312 (Electronic)
IS  - 0196-206X (Linking)
VI  - 33
IP  - 7
DP  - 2012 Sep
TI  - Ethical challenges in the care of children and families affected by life-limiting
      neuromuscular diseases.
PG  - 548-61
AB  - OBJECTIVE: We sought to understand how neuromuscular clinicians respond to the
      ethical challenges that arise in caring for children with life-limiting
      neuromuscular diseases. METHODS: We conducted a national survey of
      interdisciplinary professionals who care for children with Duchenne Muscular
      Dystrophy and Spinal Muscular Atrophy Type-1 to document their knowledge,
      attitudes, beliefs and reported practices with regard to prominent ethical
      challenges, and their suggestions for ethics interventions that would assist them
      in improving clinical practice. RESULTS: 157 participants completed paper or
      electronic surveys for an overall participation rate of 24%. A significant
      minority of respondents were either unaware of or chose not to adopt relevant
      ethical guidelines, and reported experiencing crises of conscience in the care of
      their patients. In response to 8 ethical dilemmas, there was variability in how
      often respondents encountered them, their comfort in addressing them, and their
      reported practices, including only 24% who have requested ethics consultation.
      CONCLUSION: Training of interdisciplinary clinicians is needed to improve their
      adoption of relevant ethical guidelines, cultivate greater awareness of diverse
      attitudes regarding the ethical permissibility of different treatment options and
      the utility of ethics consultation, and foster greater confidence and competence 
      in responding to ethical challenges that arise in pediatric neuromuscular
      practice.
FAU - Geller, Gail
AU  - Geller G
AD  - Berman Institute of Bioethics, Johns Hopkins University, Baltimore, MD 21205,
      USA. ggeller@jhu.edu
FAU - Harrison, Krista L
AU  - Harrison KL
FAU - Rushton, Cynda H
AU  - Rushton CH
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Dev Behav Pediatr
JT  - Journal of developmental and behavioral pediatrics : JDBP
JID - 8006933
SB  - IM
MH  - Adult
MH  - Aged
MH  - Ethics Consultation/*statistics & numerical data
MH  - Female
MH  - Health Personnel/*ethics/psychology
MH  - Health Surveys
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Muscular Dystrophy, Duchenne/therapy
MH  - Neuromuscular Diseases/*therapy
MH  - Physicians/*ethics/psychology
MH  - Spinal Muscular Atrophies of Childhood/therapy
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2012/09/06 06:00
MHDA- 2013/02/15 06:00
CRDT- 2012/09/06 06:00
PHST- 2012/09/06 06:00 [entrez]
PHST- 2012/09/06 06:00 [pubmed]
PHST- 2013/02/15 06:00 [medline]
AID - 10.1097/DBP.0b013e318267c62d [doi]
AID - 00004703-201209000-00005 [pii]
PST - ppublish
SO  - J Dev Behav Pediatr. 2012 Sep;33(7):548-61. doi: 10.1097/DBP.0b013e318267c62d.


PMID- 22947571
OWN - NLM
STAT- MEDLINE
DCOM- 20121231
LR  - 20211021
IS  - 1478-5242 (Electronic)
IS  - 0960-1643 (Linking)
VI  - 62
IP  - 602
DP  - 2012 Sep
TI  - Medical ethics debate: access to NHS resources.
PG  - 487
LID - 10.3399/bjgp12X654696 [doi]
FAU - Awatli, Ishaac
AU  - Awatli I
AD  - King's College London.
FAU - Bower, Guy
AU  - Bower G
FAU - Jeyabaladevan, Sharenja
AU  - Jeyabaladevan S
FAU - Keynejad, Roxanne
AU  - Keynejad R
FAU - Madanire, Vongai
AU  - Madanire V
FAU - Michell, Alice
AU  - Michell A
FAU - Thompson, Daniel
AU  - Thompson D
FAU - Yao, Mark
AU  - Yao M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Gen Pract
JT  - The British journal of general practice : the journal of the Royal College of
      General Practitioners
JID - 9005323
SB  - IM
EIN - Br J Gen Pract. 2012 Dec;62(605):629. Awatli, Ishaac [added]; Bower, Guy [added];
      Jeyabaladevan, Sharenja [added]; Madinare, Vongai [added]; Thompson, Daniel
      [added]; Yao, Mark [added]
MH  - Emigration and Immigration
MH  - Health Services Accessibility/*ethics
MH  - Humans
MH  - Renal Dialysis/ethics
MH  - State Medicine/*ethics
MH  - United Kingdom
PMC - PMC3426588
EDAT- 2012/09/06 06:00
MHDA- 2013/01/01 06:00
CRDT- 2012/09/06 06:00
PHST- 2012/09/06 06:00 [entrez]
PHST- 2012/09/06 06:00 [pubmed]
PHST- 2013/01/01 06:00 [medline]
AID - 10.3399/bjgp12X654696 [doi]
PST - ppublish
SO  - Br J Gen Pract. 2012 Sep;62(602):487. doi: 10.3399/bjgp12X654696.


PMID- 22947200
OWN - NLM
STAT- MEDLINE
DCOM- 20121210
LR  - 20220129
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 13
DP  - 2012 Sep 4
TI  - The ethical decisions UK doctors make regarding advanced cancer patients at the
      end of life--the perceived (in) appropriateness of anticoagulation for venous
      thromboembolism: a qualitative study.
PG  - 22
AB  - BACKGROUND: Cancer patients are at risk of developing blood clots in their veins 
      - venous thromboembolism (VTE) - which often takes the form of a pulmonary
      embolism or deep vein thrombosis. The risk increases with advanced disease.
      Evidence based treatment is low molecular weight heparin (LMWH) by daily
      subcutaneous injection. The aim of this research is to explore the barriers for
      doctors in the UK when diagnosing and treating advanced cancer patients with VTE.
      METHOD: Qualitative, in-depth interview study with 45 doctors (30 across
      Yorkshire, England and 15 across South Wales). Doctors were from three
      specialties: oncology, palliative medicine and general practice, with a mixture
      of senior and junior staff. Framework analysis was used. RESULTS: Doctors
      opinions as to whether LMWH treatment was ethically appropriate for patients who 
      were symptomatic from VTE but at end of life existed on a shifting continuum,
      largely influenced by patient prognosis. A lack of immediate benefit coupled with
      the discomfort of a daily injection had influenced some doctors not to prescribe 
      LMWH. The point at which LMWH injections should be stopped in patients at the end
      of life was ambiguous. Some perceived 'overcaution' in their own and other
      clinicians' treatment of patients. Viewpoints were divergent on whether dying of 
      a PE was considered a "good way to go". The interventionalism and ethos of
      palliative medicine was discussed. CONCLUSIONS: Decisions are difficult for
      doctors to make regarding LMWH treatment for advanced cancer patients with VTE.
      Treatment for this patient group is bounded to the doctors own moral and ethical 
      frameworks.
FAU - Sheard, Laura
AU  - Sheard L
AD  - Area 2, Health Sciences, Seebohm Rowntree Building, University of York, York YO10
      5DD, England. Laura.sheard@york.ac.uk
FAU - Prout, Hayley
AU  - Prout H
FAU - Dowding, Dawn
AU  - Dowding D
FAU - Noble, Simon
AU  - Noble S
FAU - Watt, Ian
AU  - Watt I
FAU - Maraveyas, Anthony
AU  - Maraveyas A
FAU - Johnson, Miriam
AU  - Johnson M
LA  - eng
GR  - PB-PG-1207-15033/DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120904
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
RN  - 0 (Anticoagulants)
RN  - 0 (Heparin, Low-Molecular-Weight)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anticoagulants/*administration & dosage
MH  - Choice Behavior/ethics
MH  - Decision Making/*ethics
MH  - Drug Prescriptions/*standards
MH  - Ethics, Medical
MH  - Female
MH  - *General Practice/standards
MH  - Heparin, Low-Molecular-Weight/administration & dosage
MH  - Hospice Care/*ethics
MH  - Humans
MH  - Male
MH  - *Medical Oncology/standards
MH  - Middle Aged
MH  - Narration
MH  - Neoplasms/*complications/pathology
MH  - *Palliative Care/standards
MH  - Physicians/*ethics
MH  - Prognosis
MH  - Pulmonary Embolism/drug therapy
MH  - Qualitative Research
MH  - United Kingdom
MH  - Venous Thromboembolism/diagnosis/*drug therapy/etiology/prevention & control
MH  - Venous Thrombosis/drug therapy
MH  - Workforce
PMC - PMC3459796
EDAT- 2012/09/06 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/09/06 06:00
PHST- 2012/02/20 00:00 [received]
PHST- 2012/08/27 00:00 [accepted]
PHST- 2012/09/06 06:00 [entrez]
PHST- 2012/09/06 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - 1472-6939-13-22 [pii]
AID - 10.1186/1472-6939-13-22 [doi]
PST - epublish
SO  - BMC Med Ethics. 2012 Sep 4;13:22. doi: 10.1186/1472-6939-13-22.


PMID- 22946957
OWN - NLM
STAT- MEDLINE
DCOM- 20130531
LR  - 20211021
IS  - 1471-244X (Electronic)
IS  - 1471-244X (Linking)
VI  - 12
DP  - 2012 Sep 5
TI  - Preventing compulsory admission to psychiatric inpatient care through
      psycho-education and crisis focused monitoring.
PG  - 136
LID - 10.1186/1471-244X-12-136 [doi]
AB  - BACKGROUND: The high number of involuntary placements of people with mental
      disorders in Switzerland and other European countries constitutes a major public 
      health issue. In view of the ethical and personal relevance of compulsory
      admission for the patients concerned and given the far-reaching effects in terms 
      of health care costs, innovative interventions to improve the current situation
      are much needed. A number of promising approaches to prevent involuntary
      placements have been proposed that target continuity of care by increasing
      self-management skills of patients. However, the effectiveness of such
      interventions in terms of more robust criteria (e.g., admission rates) has not
      been sufficiently analysed in larger study samples. The current study aims to
      evaluate an intervention programme for patients at high risk of compulsory
      admission to psychiatric hospitals. Effectiveness will be assessed in terms of a 
      reduced number of psychiatric hospitalisations and days of inpatient care in
      connection with involuntary psychiatric admissions as well as in terms of
      cost-containment in inpatient mental health care. The intervention furthermore
      intends to reduce the degree of patients' perceived coercion and to increase
      patient satisfaction, their quality of life and empowerment. METHODS/DESIGN: This
      paper describes the design of a randomised controlled intervention study
      conducted currently at four psychiatric hospitals in the Canton of Zurich. The
      intervention programme consists of individualised psycho-education focusing on
      behaviours prior to and during illness-related crisis, the distribution of a
      crisis card and, after inpatient admission, a 24-month preventive monitoring of
      individual risk factors for compulsory re-admission to hospital. All measures are
      provided by a mental health care worker who maintains permanent contact to the
      patient over the course of the study. In order to prove its effectiveness the
      intervention programme will be compared with standard care procedures (control
      group). 200 patients each will be assigned to the intervention group or to the
      control group. Detailed follow-up assessments of service use, psychopathology and
      patient perceptions are scheduled 12 and 24 months after discharge. DISCUSSION:
      Innovative interventions have to be established to prevent patients with mental
      disorders from undergoing the experience of compulsory admission and, with regard
      to society as a whole, to reduce the costs of health care (and detention). The
      current study will allow for a prospective analysis of the effectiveness of an
      intervention programme, providing insight into processes and factors that
      determine involuntary placement.
FAU - Lay, Barbara
AU  - Lay B
AD  - Psychiatric University Hospital Zurich, Zurich, Switzerland.
      barbara.lay@bli.uzh.ch
FAU - Salize, Hans Joachim
AU  - Salize HJ
FAU - Dressing, Harald
AU  - Dressing H
FAU - Rusch, Nicolas
AU  - Rusch N
FAU - Schonenberger, Thekla
AU  - Schonenberger T
FAU - Buhlmann, Monika
AU  - Buhlmann M
FAU - Bleiker, Marco
AU  - Bleiker M
FAU - Lengler, Silke
AU  - Lengler S
FAU - Korinth, Lena
AU  - Korinth L
FAU - Rossler, Wulf
AU  - Rossler W
LA  - eng
SI  - ISRCTN/ISRCTN63162737
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20120905
PL  - England
TA  - BMC Psychiatry
JT  - BMC psychiatry
JID - 100968559
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Coercion
MH  - *Hospitals, Psychiatric/economics
MH  - Humans
MH  - Inpatients/*psychology
MH  - Length of Stay/*economics
MH  - Mental Health Services/*economics
MH  - Middle Aged
MH  - Multicenter Studies as Topic/economics/methods/standards
MH  - *Patient Admission/economics/standards
MH  - Patient Satisfaction/economics
MH  - Power, Psychological
MH  - Psychotherapy/*methods
MH  - Quality of Life/psychology
MH  - Randomized Controlled Trials as Topic/economics/methods/standards
MH  - Switzerland
MH  - Young Adult
PMC - PMC3532124
EDAT- 2012/09/06 06:00
MHDA- 2013/06/01 06:00
CRDT- 2012/09/06 06:00
PHST- 2011/08/11 00:00 [received]
PHST- 2012/08/31 00:00 [accepted]
PHST- 2012/09/06 06:00 [entrez]
PHST- 2012/09/06 06:00 [pubmed]
PHST- 2013/06/01 06:00 [medline]
AID - 1471-244X-12-136 [pii]
AID - 10.1186/1471-244X-12-136 [doi]
PST - epublish
SO  - BMC Psychiatry. 2012 Sep 5;12:136. doi: 10.1186/1471-244X-12-136.


PMID- 22946915
OWN - NLM
STAT- MEDLINE
DCOM- 20130102
LR  - 20191210
IS  - 1757-6199 (Electronic)
IS  - 1757-6180 (Linking)
VI  - 4
IP  - 16
DP  - 2012 Aug
TI  - Validation of a bioanalytical method using capillary microsampling of 8 microl
      plasma samples: application to a toxicokinetic study in mice.
PG  - 1989-98
LID - 10.4155/bio.12.177 [doi]
AB  - BACKGROUND: Capillary microsampling was recently introduced as a new technique
      for simplified collection and handling of small, exact volumes of liquid
      matrices. In this article, a bioanalytical method was developed and fully
      validated for 8 microl plasma samples and applied to a toxicology study in mice. 
      RESULTS: The method was validated in the concentration range 0.06-30 microM. A
      procedure where 32 microl of blood was collected for preparation of 8 microl
      plasma was successfully implemented at the animal facility. All the results for
      the method and study validation met the requirements of a regulated assay.
      CONCLUSION: It is shown that 8 microl plasma microsamples can be sampled and
      analyzed with consistently excellent accuracy and precision. Capillary
      microsampling of plasma offers a possibility to combine ethical, scientific and
      economic benefits while still maintaining the advantage of having drug exposure
      data in plasma.
FAU - Jonsson, Ove
AU  - Jonsson O
AD  - Global DMPK, Screening and Profiling, AstraZeneca R&D, Sodertalje, Sweden.
      ovex.jonsson@gmail.com
FAU - Villar, Rodrigo Palma
AU  - Villar RP
FAU - Nilsson, Lars B
AU  - Nilsson LB
FAU - Eriksson, Marie
AU  - Eriksson M
FAU - Konigsson, Kristian
AU  - Konigsson K
LA  - eng
PT  - Journal Article
PT  - Validation Study
PL  - England
TA  - Bioanalysis
JT  - Bioanalysis
JID - 101512484
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Blood Specimen Collection/instrumentation/*methods
MH  - Calibration
MH  - Chromatography, High Pressure Liquid/methods
MH  - Drug Evaluation, Preclinical/methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Mice
MH  - Pharmaceutical Preparations/*blood
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Tandem Mass Spectrometry/methods
EDAT- 2012/09/06 06:00
MHDA- 2013/01/03 06:00
CRDT- 2012/09/06 06:00
PHST- 2012/09/06 06:00 [entrez]
PHST- 2012/09/06 06:00 [pubmed]
PHST- 2013/01/03 06:00 [medline]
AID - 10.4155/bio.12.177 [doi]
PST - ppublish
SO  - Bioanalysis. 2012 Aug;4(16):1989-98. doi: 10.4155/bio.12.177.


PMID- 22946236
OWN - NLM
STAT- MEDLINE
DCOM- 20120927
LR  - 20131106
IS  - 0952-6862 (Print)
IS  - 0952-6862 (Linking)
VI  - 25
IP  - 6
DP  - 2012
TI  - Uncovering the common ground in qualitative inquiry: combining quality
      improvement and phenomenology in clinical nursing research.
PG  - 532-48
AB  - PURPOSE: The purpose of this paper is to describe the use of a common qualitative
      data set analysed with both a quality improvement tool to facilitate service
      improvement, and a rigorous research methodology to engage beginning nurse
      researchers in a mentored project. DESIGN/METHODOLOGY/APPROACH: A qualitative
      cohort study of the experience of hospitalisation across six diagnostic groups
      interrogated data from 104 patient and carer interviews using the Picker
      Dimensions of Experience and Heideggerian Phenomenology. FINDINGS: The paper
      reveals that well-conducted qualitative interviews can provide common ground for 
      service improvement initiatives and rigorous research analysis. RESEARCH
      LIMITATIONS/IMPLICATIONS: The Picker Dimensions use simple coding methods that
      push findings towards utility, but at times are overly reductionist and exile any
      data not related to hospital services. Heideggerian phenomenology is training and
      resource intensive, but its exploration of the meaning of the illness experience 
      provides a profound backdrop for the subsequent understanding of hospitalisation.
      PRACTICAL IMPLICATIONS: The access that qualitative data provides to the patient 
      and family's perspective is becoming increasingly valued in processes of ongoing 
      quality improvement, clinical redesign and evaluation for hospital accreditation.
      SOCIAL IMPLICATIONS: The intrinsic rewards of deep qualitative analysis for the
      staff involved are extraordinary. Clinicians were humbled by new understandings, 
      which surprised them despite their long clinical experience. ORIGINALITY/VALUE:
      While quality improvement processes require training, ethics applications and
      data collection, the same framework can support rigorous qualitative research
      through use of the data as "common ground". The researchers experienced a
      tension, but eventually, a balance between the strengths and limitations of these
      combined modes of qualitative inquiry:
FAU - Gullick, Janice
AU  - Gullick J
AD  - Concord Repatriation General Hospital, Sydney, Australia.
FAU - West, Sandra
AU  - West S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Health Care Qual Assur
JT  - International journal of health care quality assurance
JID - 8916799
MH  - Attitude of Health Personnel
MH  - Clinical Nursing Research/*methods/*organization & administration
MH  - Cohort Studies
MH  - Data Collection
MH  - Humans
MH  - Patient Safety
MH  - Qualitative Research
MH  - Quality Improvement/*organization & administration
MH  - Research Design
EDAT- 2012/09/06 06:00
MHDA- 2012/09/28 06:00
CRDT- 2012/09/06 06:00
PHST- 2012/09/06 06:00 [entrez]
PHST- 2012/09/06 06:00 [pubmed]
PHST- 2012/09/28 06:00 [medline]
AID - 10.1108/09526861211246485 [doi]
PST - ppublish
SO  - Int J Health Care Qual Assur. 2012;25(6):532-48. doi: 10.1108/09526861211246485.


PMID- 22945963
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 5
DP  - 2012
TI  - Protocol Evaluating the effectiveness of a school-based group programme for
      parents of children at risk of ADHD: the 'PArents, Teachers and CHildren WORKing 
      Together (PATCHWORK)' cluster RCT protocol.
LID - 10.1136/bmjopen-2012-001783 [doi]
LID - e001783 [pii]
AB  - INTRODUCTION: Early intervention for childhood behavioural problems may help
      improve health and educational outcomes in affected children and reduce the
      likelihood of developing additional difficulties. The National Institute for
      Health and Clinical Excellence guidelines for attention deficit/hyperactivity
      disorder (ADHD), a common childhood behavioural disorder, recommend a stepped
      care approach for the identification and management of these problems. Parents of
      children with high levels of hyperactivity and inattention may benefit from
      intervention programmes involving behavioural management and educational
      approaches. Such interventions may be further enhanced by providing training and 
      feedback to teachers about the strategies discussed with parents. In relation to 
      children with high levels of hyperactivity, impulsiveness and inattention, we aim
      to test the feasibility and effectiveness of a parenting programme (with and
      without an accompanying teacher session) in primary schools. METHODS AND
      ANALYSIS: This clustered (at the level of school) randomised controlled trial
      (RCT) focuses on children in their first four school years (ages 4-8 years) in
      the East Midlands area of England. Parents will complete a screening measure, the
      Strengths and Difficulties Questionnaire, to identify children with high levels
      of hyperactivity/inattention. Three approaches to reducing hyperactivity and
      attention problems will be compared: a group programme for parents (parent-only
      intervention); group programme for parents combined with feedback to teachers
      (combined intervention); and waiting list control (no intervention). Differences 
      between arms on the short version of Conners' Parent and Teacher Rating Scales
      Revised will be compared and also used to inform the sample size required for a
      future definitive cluster RCT. A preliminary cost-effectiveness analysis will
      also be conducted. ETHICS AND DISSEMINATION: The outcomes of this study will
      inform policy makers about the feasibility, acceptability and effectiveness of
      delivering targeted behavioural interventions within a school setting. The study 
      has received ethical approval from the University of Nottingham Medical School
      Ethics Committee. TRIAL REGISTRATION: ISRCTN87634685.
FAU - Sayal, Kapil
AU  - Sayal K
AD  - Division of Psychiatry, School of Community Health Sciences, University of
      Nottingham, Nottingham, Nottinghamshire, UK.
FAU - Daley, David
AU  - Daley D
FAU - James, Marilyn
AU  - James M
FAU - Yang, Min
AU  - Yang M
FAU - Batty, Martin J
AU  - Batty MJ
FAU - Taylor, John A
AU  - Taylor JA
FAU - Pass, Sarah
AU  - Pass S
FAU - Sampson, Christopher James
AU  - Sampson CJ
FAU - Sellman, Edward
AU  - Sellman E
FAU - Valentine, Althea
AU  - Valentine A
FAU - Hollis, Chris
AU  - Hollis C
LA  - eng
PT  - Journal Article
DEP - 20120903
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3437425
EDAT- 2012/09/05 06:00
MHDA- 2012/09/05 06:01
CRDT- 2012/09/05 06:00
PHST- 2012/09/05 06:00 [entrez]
PHST- 2012/09/05 06:00 [pubmed]
PHST- 2012/09/05 06:01 [medline]
AID - bmjopen-2012-001783 [pii]
AID - 10.1136/bmjopen-2012-001783 [doi]
PST - epublish
SO  - BMJ Open. 2012 Sep 3;2(5). pii: bmjopen-2012-001783. doi:
      10.1136/bmjopen-2012-001783. Print 2012.


PMID- 22945728
OWN - NLM
STAT- MEDLINE
DCOM- 20130108
LR  - 20181201
IS  - 1998-3603 (Electronic)
IS  - 0970-9290 (Linking)
VI  - 23
IP  - 2
DP  - 2012 Mar-Apr
TI  - Ethical guidelines on authorship.
PG  - 292
LID - 10.4103/0970-9290.100445 [doi]
FAU - Zaki, Syed Ahmed
AU  - Zaki SA
FAU - Taqi, Syed Ahmed
AU  - Taqi SA
FAU - Sami, Lateef Begum
AU  - Sami LB
FAU - Nilofer, Angadi Rajasab
AU  - Nilofer AR
LA  - eng
PT  - Letter
PT  - Comment
PL  - India
TA  - Indian J Dent Res
JT  - Indian journal of dental research : official publication of Indian Society for
      Dental Research
JID - 9202990
CON - Indian J Dent Res. 2010 Jul-Sep;21(3):315. PMID: 20930334
MH  - *Authorship
MH  - *Ethics, Research
MH  - Humans
MH  - Publishing/*ethics
EDAT- 2012/09/05 06:00
MHDA- 2013/01/09 06:00
CRDT- 2012/09/05 06:00
PHST- 2012/09/05 06:00 [entrez]
PHST- 2012/09/05 06:00 [pubmed]
PHST- 2013/01/09 06:00 [medline]
AID - IndianJDentRes_2012_23_2_292_100445 [pii]
AID - 10.4103/0970-9290.100445 [doi]
PST - ppublish
SO  - Indian J Dent Res. 2012 Mar-Apr;23(2):292. doi: 10.4103/0970-9290.100445.


PMID- 22945395
OWN - NLM
STAT- MEDLINE
DCOM- 20121129
LR  - 20211021
IS  - 1471-0064 (Electronic)
IS  - 1471-0056 (Linking)
VI  - 13
IP  - 10
DP  - 2012 Oct
TI  - Comprehensive pre-implantation genetic screening: ethical reflection urgently
      needed.
PG  - 676-7
LID - 10.1038/nrg3334 [doi]
FAU - Hens, Kristien
AU  - Hens K
AD  - GROW, School for Oncology and Developmental Biology, Maastricht University, PO
      BOX 616, 6200 Maastricht, The Netherlands. k.hens@maastrichtuniversity.nl
FAU - Dondorp, Wybo
AU  - Dondorp W
FAU - Geraedts, Joep
AU  - Geraedts J
FAU - de Wert, Guido
AU  - de Wert G
LA  - eng
PT  - Journal Article
DEP - 20120904
PL  - England
TA  - Nat Rev Genet
JT  - Nature reviews. Genetics
JID - 100962779
SB  - IM
MH  - Comparative Genomic Hybridization
MH  - Comprehensive Health Care/ethics
MH  - Female
MH  - Fertilization in Vitro/ethics/methods
MH  - Genetic Testing/ethics/methods
MH  - Group Processes
MH  - *Health Services Needs and Demand/ethics
MH  - Humans
MH  - Microarray Analysis/ethics/methods/statistics & numerical data
MH  - Polymorphism, Single Nucleotide
MH  - Pregnancy
MH  - Preimplantation Diagnosis/*ethics/methods
MH  - Reproductive Medicine/ethics/methods
EDAT- 2012/09/05 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/09/05 06:00
PHST- 2012/09/05 06:00 [entrez]
PHST- 2012/09/05 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - nrg3334 [pii]
AID - 10.1038/nrg3334 [doi]
PST - ppublish
SO  - Nat Rev Genet. 2012 Oct;13(10):676-7. doi: 10.1038/nrg3334. Epub 2012 Sep 4.


PMID- 22944290
OWN - NLM
STAT- MEDLINE
DCOM- 20140512
LR  - 20130628
IS  - 1578-2190 (Electronic)
IS  - 0001-7310 (Linking)
VI  - 104
IP  - 6
DP  - 2013 Jul-Aug
TI  - Ethics in dermatology: toward a new paradigm.
PG  - 480-7
LID - 10.1016/j.ad.2012.07.001 [doi]
LID - S0001-7310(12)00307-9 [pii]
AB  - Medical ethics have evolved over time, and ethical responsibilities have often
      been shared by priests, the governing classes, and physicians. The emergence of
      scientific medicine led to the separation of functions, yet physicians have
      nonetheless continued to enjoy an extraordinary degree of moral authority and
      great social privilege. From this starting point, professional medical ethics
      developed as a specific moral system based on special rights and duties
      (paternalism and medical confidentiality). Various historical events brought this
      longstanding situation to a point of crisis toward the middle of the 20th
      century, and for several decades since, medical ethics have been based on freedom
      of choice for the patient with regard to decisions about his or her own body and 
      health. Recent developments have created a new, still poorly defined model that
      takes into consideration such matters as euthanasia, abortion, provision of
      information on the benefits and harm of treatments, the sharing of therapeutic
      decision-making with the patient and/or family members, the choice of public or
      private medical providers, therapeutic guidelines, and the extension of the scope
      of practice to include preventive measures and cosmetic procedures. What is
      needed now is a new ethical system for plural societies that harbor different
      religions, beliefs and lifestyles, but that is also rational, universal and
      subject to ongoing revision-a system always striving for scientific, technical
      and moral excellence. Such an ethical system would have to be taught in medical
      schools, as it would need to bear fruit beyond mere good intentions.
CI  - Copyright (c) 2012 Elsevier Espana, S.L. and AEDV. All rights reserved.
FAU - Lopez-Martin, S
AU  - Lopez-Martin S
AD  - Clinica Capio, Talavera de la Reina, Toledo, Spain.
FAU - Galera-Martin, C
AU  - Galera-Martin C
FAU - Guerra-Tapia, A
AU  - Guerra-Tapia A
LA  - eng
LA  - spa
PT  - Journal Article
DEP - 20120901
PL  - Spain
TA  - Actas Dermosifiliogr
JT  - Actas dermo-sifiliograficas
JID - 0373062
SB  - IM
MH  - Dermatology/*ethics
MH  - Ethics, Medical
EDAT- 2012/09/05 06:00
MHDA- 2014/05/13 06:00
CRDT- 2012/09/05 06:00
PHST- 2012/04/24 00:00 [received]
PHST- 2012/07/04 00:00 [revised]
PHST- 2012/07/07 00:00 [accepted]
PHST- 2012/09/05 06:00 [entrez]
PHST- 2012/09/05 06:00 [pubmed]
PHST- 2014/05/13 06:00 [medline]
AID - S0001-7310(12)00307-9 [pii]
AID - 10.1016/j.ad.2012.07.001 [doi]
PST - ppublish
SO  - Actas Dermosifiliogr. 2013 Jul-Aug;104(6):480-7. doi: 10.1016/j.ad.2012.07.001.
      Epub 2012 Sep 1.


PMID- 22943618
OWN - NLM
STAT- MEDLINE
DCOM- 20130102
LR  - 20120904
IS  - 1757-6199 (Electronic)
IS  - 1757-6180 (Linking)
VI  - 4
IP  - 15
DP  - 2012 Aug
TI  - Applications of accelerator MS in pediatric drug evaluation.
PG  - 1871-82
LID - 10.4155/bio.12.173 [doi]
AB  - Accelerator MS (AMS) provides a novel method for obtaining and analyzing
      pharmacokinetics and pharmacodynamics in children. This paper reviews the
      scientific and ethical rationale for AMS in pediatric trials, the regulatory
      framework and general considerations with some specific examples of pediatric
      clinical trials using AMS. Microdosing in the context of this article refers to
      studies using a negligible amount (nanocuries) of (14)C as tracer, and AMS as a
      quantitative technique. The technology is by no means a panacea for the
      deficiency in pediatric clinical research; however, it lessens the challenges and
      provides the most quantitative tool for pediatric pharmacology studies.
FAU - Vuong, L T
AU  - Vuong LT
AD  - Vitalea Science, Inc., Davis, CA 95618, USA. le@ltvuong.com
FAU - Blood, A B
AU  - Blood AB
FAU - Vogel, J S
AU  - Vogel JS
FAU - Anderson, M E
AU  - Anderson ME
FAU - Goldstein, B
AU  - Goldstein B
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Bioanalysis
JT  - Bioanalysis
JID - 101512484
RN  - 0 (Carbon Radioisotopes)
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Adolescent
MH  - *Biological Availability
MH  - Carbon Radioisotopes/analysis
MH  - Child
MH  - Child, Preschool
MH  - Clinical Trials as Topic
MH  - Drug Evaluation/*methods
MH  - Europe
MH  - Female
MH  - Guidelines as Topic
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Mass Spectrometry/*methods
MH  - Pharmaceutical Preparations/metabolism
MH  - Pregnancy
MH  - United States
MH  - United States Food and Drug Administration/legislation & jurisprudence
EDAT- 2012/09/05 06:00
MHDA- 2013/01/03 06:00
CRDT- 2012/09/05 06:00
PHST- 2012/09/05 06:00 [entrez]
PHST- 2012/09/05 06:00 [pubmed]
PHST- 2013/01/03 06:00 [medline]
AID - 10.4155/bio.12.173 [doi]
PST - ppublish
SO  - Bioanalysis. 2012 Aug;4(15):1871-82. doi: 10.4155/bio.12.173.


PMID- 22943556
OWN - NLM
STAT- MEDLINE
DCOM- 20130826
LR  - 20121113
IS  - 1743-1328 (Electronic)
IS  - 0161-6412 (Linking)
VI  - 34
IP  - 10
DP  - 2012 Dec
TI  - Hyperbaric oxygen is effective in early stage of healing of experimental brain
      abscess in rats.
PG  - 931-6
LID - 10.1179/1743132812Y.0000000091 [doi]
AB  - OBJECTIVES: Current therapy of brain abscess (BA) includes a combined approach
      that involves antibiotics and minimal invasive surgery, but also hyperbaric
      oxygen treatment (HBOT) as a supportive measure. Optimum treatment is still a
      matter of significant controversy. METHODS: The experiment, previously approved
      by a relevant ethical committee, involved 80 female Wistar rats. BA was
      experimentally induced by inoculation of Staphylococcus aureus. The animals were 
      randomized into groups and treated either with antibiotics, HBOT, or with a
      combination of both. RESULTS: Beneficial effect of HBOT was evident in groups
      treated with HBOT or with a combination of antibiotic+HBOT. It was mainly
      manifested on days three and five of the experiment and was evident as
      statistically significant increase of a number of newly formed blood vessels,
      increase in mean vascular density, and smaller abscess necrotic core. DISCUSSION:
      Although the results of the present study should be interpreted cautiously, they 
      suggest that HBOT has an important but limited role in the treatment of BA.
FAU - Bilic, Ivica
AU  - Bilic I
AD  - Department of Neurology, University Hospital Center Split, Croatia.
      ibilic@kbsplit.hr
FAU - Petri, Nadan M
AU  - Petri NM
FAU - Krstulja, Mira
AU  - Krstulja M
FAU - Vuckovic, Meri
AU  - Vuckovic M
FAU - Salamunic, Ilza
AU  - Salamunic I
FAU - Kraljevic, Katarina Sisko
AU  - Kraljevic KS
FAU - Capkun, Vesna
AU  - Capkun V
FAU - Lusic, Ivo
AU  - Lusic I
LA  - eng
PT  - Journal Article
DEP - 20120829
PL  - England
TA  - Neurol Res
JT  - Neurological research
JID - 7905298
SB  - IM
MH  - Animals
MH  - Brain Abscess/microbiology/*therapy
MH  - *Disease Models, Animal
MH  - Female
MH  - Hyperbaric Oxygenation/*methods
MH  - Random Allocation
MH  - Rats
MH  - Rats, Wistar
MH  - Staphylococcal Infections/metabolism/*therapy
MH  - *Staphylococcus aureus
MH  - Time Factors
MH  - Treatment Outcome
MH  - Wound Healing/*physiology
EDAT- 2012/09/05 06:00
MHDA- 2013/08/27 06:00
CRDT- 2012/09/05 06:00
PHST- 2012/09/05 06:00 [entrez]
PHST- 2012/09/05 06:00 [pubmed]
PHST- 2013/08/27 06:00 [medline]
AID - ner2921 [pii]
AID - 10.1179/1743132812Y.0000000091 [doi]
PST - ppublish
SO  - Neurol Res. 2012 Dec;34(10):931-6. doi: 10.1179/1743132812Y.0000000091. Epub 2012
      Aug 29.


PMID- 22943224
OWN - NLM
STAT- MEDLINE
DCOM- 20121126
LR  - 20211021
IS  - 1478-7083 (Electronic)
IS  - 0035-8843 (Linking)
VI  - 94
IP  - 5
DP  - 2012 Jul
TI  - The influence of process and patient factors on the recall of consent information
      in mentally competent patients undergoing surgery for neck of femur fractures.
PG  - 308-12
LID - 10.1308/003588412X13171221591970 [doi]
AB  - INTRODUCTION: Informed consent is an ethical and legal prerequisite for major
      surgical procedures. Recent literature has identified 'poor consent' as a major
      cause of litigation in trauma cases. We aimed to investigate the patient and
      process factors that influence consent information recall in mentally competent
      patients (abbreviated mental test score [AMTS] >/=6) presenting with neck of
      femur (NOF) fractures. METHODS: A prospective study was conducted at a tertiary
      unit. Fifty NOF patients (cases) and fifty total hip replacement (THR) patients
      (controls) were assessed for process factors (adequacy and validity of consent)
      as well as patient factors (comprehension and retention) using consent forms and 
      structured interview proformas. RESULTS: The two groups were matched for ASA
      (American Society of Anesthesiologists) grade and AMTS. The consent forms were
      adequate in both groups but scored poorly for validity in the NOF group. Only 26%
      of NOF patients remembered correctly what surgery they had while only 48%
      recalled the risks and benefits of the procedure. These results were
      significantly poorer than in THR patients (p = 0.0001). CONCLUSIONS: This study
      confirms that NOF patients are poor at remembering the information conveyed to
      them at the time of consent when compared with THR patients despite being
      intellectually and physiologically matched. We suggest using preprinted consent
      forms (process factors), information sheets and visual aids (patient factors) to 
      improve retention and recall.
FAU - Khan, S K
AU  - Khan SK
AD  - South Tees Hospitals NHS Foundation Trust, UK. sameer.khan@doctors.net.uk
FAU - Karuppaiah, K
AU  - Karuppaiah K
FAU - Bajwa, A S
AU  - Bajwa AS
LA  - eng
PT  - Journal Article
PL  - England
TA  - Ann R Coll Surg Engl
JT  - Annals of the Royal College of Surgeons of England
JID - 7506860
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - *Consent Forms
MH  - Female
MH  - Femoral Neck Fractures/psychology/*surgery
MH  - Humans
MH  - Informed Consent/*psychology
MH  - Male
MH  - *Mental Competency
MH  - *Mental Recall
MH  - Middle Aged
MH  - Prospective Studies
PMC - PMC3954370
EDAT- 2012/09/05 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/09/05 06:00
PHST- 2012/09/05 06:00 [entrez]
PHST- 2012/09/05 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1308/003588412X13171221591970 [doi]
PST - ppublish
SO  - Ann R Coll Surg Engl. 2012 Jul;94(5):308-12. doi:
      10.1308/003588412X13171221591970.


PMID- 22943139
OWN - NLM
STAT- MEDLINE
DCOM- 20130712
LR  - 20191210
IS  - 1466-447X (Electronic)
IS  - 0264-0414 (Linking)
VI  - 31
IP  - 1
DP  - 2013
TI  - An evaluation of the external validity and reliability of a rugby league match
      simulation protocol.
PG  - 48-57
LID - 10.1080/02640414.2012.720702 [doi]
AB  - The aim of this study was to assess the external validity and reliability of a
      novel rugby league match simulation protocol. With ethical approval, 16 males
      (age 22.4 +/- 7.1 years, estimated (.)VO(2max) 52.1 +/- 4.5 ml . kg(-)(1) .
      min(-)(1)) performed the rugby league match simulation protocol on two occasions 
      10 to 14 days apart. During the rugby league match simulation protocol
      participants covered a total distance of 8,444 +/- 212 m, at an overall
      locomotive rate of 97.3 +/- 2.5 m . min(-)(1). In addition, changes in very high 
      (-22.4%), high (-8.6%) and low intensity (1.6%) running locomotive rates from the
      first to the fourth quarter were observed. The magnitude of these movement
      characteristics did not differ significantly (P > 0.05) between repeated trials, 
      with coefficients of variation of 1.1, 4.2 and 10.6%, and 95% limits of agreement
      of -0.4 +/- 4.0, -0.3 +/- 3.6, and -0.2 +/- 4.4 m . min(-)(1) for overall, high
      and very high intensity running locomotive rates, respectively. On this evidence,
      the rugby league match simulation protocol replicates the movement demands
      observed during elite rugby league matches. Furthermore, the protocol can be
      performed reliably amongst non-elite sports players and thereby has the potential
      to be used as a tool for monitoring the effectiveness of various interventions on
      physical match performance.
FAU - Sykes, Dave
AU  - Sykes D
AD  - Sport & Exercise Sciences, University of Chester, Parkgate Road, Chester CH1 4BJ,
      United Kingdom.
FAU - Nicholas, Ceri
AU  - Nicholas C
FAU - Lamb, Kevin
AU  - Lamb K
FAU - Twist, Craig
AU  - Twist C
LA  - eng
PT  - Journal Article
PT  - Validation Study
DEP - 20120904
PL  - England
TA  - J Sports Sci
JT  - Journal of sports sciences
JID - 8405364
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Athletic Performance
MH  - *Competitive Behavior
MH  - *Football
MH  - Humans
MH  - Male
MH  - *Models, Theoretical
MH  - Oxygen Consumption
MH  - *Physical Exertion
MH  - Reproducibility of Results
MH  - *Running
MH  - Young Adult
EDAT- 2012/09/05 06:00
MHDA- 2013/07/16 06:00
CRDT- 2012/09/05 06:00
PHST- 2012/09/05 06:00 [entrez]
PHST- 2012/09/05 06:00 [pubmed]
PHST- 2013/07/16 06:00 [medline]
AID - 10.1080/02640414.2012.720702 [doi]
PST - ppublish
SO  - J Sports Sci. 2013;31(1):48-57. doi: 10.1080/02640414.2012.720702. Epub 2012 Sep 
      4.


PMID- 28091257
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 2047-9018 (Electronic)
IS  - 0029-6570 (Linking)
VI  - 27
IP  - 1
DP  - 2012 Sep 5
TI  - Planning ahead can help ensure patient's wishes are expressed.
PG  - 32
LID - 10.7748/ns.27.1.32.s45 [doi]
AB  - The article on cardiopulmonary resuscitation in end of life care (art&science
      August 22) was thought-provoking, most notably for its focus on the ethical,
      legal and professional issues associated with any decisions taken in these
      circumstances.
FAU - Garland, Sara
AU  - Garland S
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Stand
JT  - Nursing standard (Royal College of Nursing (Great Britain) : 1987)
JID - 9012906
EDAT- 2012/09/05 00:00
MHDA- 2012/09/05 00:01
CRDT- 2017/01/17 06:00
PHST- 2017/01/17 06:00 [entrez]
PHST- 2012/09/05 00:00 [pubmed]
PHST- 2012/09/05 00:01 [medline]
AID - 10.7748/ns.27.1.32.s45 [doi]
PST - ppublish
SO  - Nurs Stand. 2012 Sep 5;27(1):32. doi: 10.7748/ns.27.1.32.s45.


PMID- 25624830
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150127
LR  - 20201001
IS  - 1673-5374 (Print)
IS  - 1673-5374 (Linking)
VI  - 7
IP  - 25
DP  - 2012 Sep 5
TI  - Neuronal differentiation of adipose-derived stem cells and their transplantation 
      for cerebral ischemia.
PG  - 1992-9
LID - 10.3969/j.issn.1673-5374.2012.25.011 [doi]
AB  - OBJECTIVE: To review published data on the biological characteristics,
      differentiation and applications of adipose-derived stem cells in ischemic
      diseases. DATA RETRIEVAL: A computer-based online search of reports published
      from January 2005 to June 2012 related to the development of adipose-derived stem
      cells and their transplantation for treatment of cerebral ischemia was performed 
      in Web of Science using the key words "adipose-derived stem cells", "neural-like 
      cells", "transplantation", "stroke", and "cerebral ischemia". SELECTION CRITERIA:
      The documents associated with the development of adipose-derived stem cells and
      their transplantation for treatment of cerebral ischemia were selected, and those
      published in the last 3-5 years or in authoritative journals were preferred in
      the same field. Totally 89 articles were obtained in the initial retrieval, of
      which 53 were chosen based on the inclusion criteria. MAIN OUTCOME MEASURES:
      Biological characteristics and induced differentiation of adipose-derived stem
      cells and cell transplantation for disease treatment as well as the underlying
      mechanism of clinical application. RESULTS: The advantages of adipose-derived
      stem cells include their ease of procurement, wide availability, rapid expansion,
      low tumorigenesis, low immunogenicity, and absence of ethical constraints.
      Preclinical experiments have demonstrated that transplanted adipose-derived stem 
      cells can improve neurological functions, reduce small regions of cerebral
      infarction, promote angiogenesis, and express neuron-specific markers. The
      improvement of neurological functions was demonstrated in experiments using
      different methods and time courses of adipose-derived stem cell transplantation, 
      but the mechanisms remain unclear. CONCLUSION: Further research into the
      treatment of ischemic disease by adipose-derived stem cell transplantation is
      needed to determine their mechanism of action.
FAU - Tian, Guoping
AU  - Tian G
AD  - Department of Neurology, Shenyang First People's Hospital, Shenyang 110041,
      Liaoning Province, China.
FAU - Zhou, Jin
AU  - Zhou J
AD  - Department of Neurology, Shenyang First People's Hospital, Shenyang 110041,
      Liaoning Province, China.
FAU - Wang, Jing'e
AU  - Wang J
AD  - Department of Neurology, Shenyang First People's Hospital, Shenyang 110041,
      Liaoning Province, China.
FAU - Xu, Bing
AU  - Xu B
AD  - Department of Neurology, Shenyang First People's Hospital, Shenyang 110041,
      Liaoning Province, China.
FAU - Li, Li
AU  - Li L
AD  - Department of Neurology, Shenyang First People's Hospital, Shenyang 110041,
      Liaoning Province, China.
FAU - Zhu, Feng
AU  - Zhu F
AD  - Department of Neurology, Shenyang First People's Hospital, Shenyang 110041,
      Liaoning Province, China.
FAU - Han, Jian
AU  - Han J
AD  - Department of Neurology, Shenyang First People's Hospital, Shenyang 110041,
      Liaoning Province, China.
FAU - Li, Jianping
AU  - Li J
AD  - Liaoning Blood Center, Shenyang 110044, Liaoning Province, China.
FAU - Zhang, Siyang
AU  - Zhang S
AD  - College of Basic Medical Science, China Medical University, Shenyang 110001,
      Liaoning Province, China.
FAU - Luo, Xiaoguang
AU  - Luo X
AD  - Department of Neurology, First Affiliated Hospital of China Medical University,
      Shenyang 110001, Liaoning Province, China.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Neural Regen Res
JT  - Neural regeneration research
JID - 101316351
PMC - PMC4298895
OTO - NOTNLM
OT  - adipose stem cells
OT  - adipose tissue
OT  - adipose-derived stem cells
OT  - cerebral ischemia
OT  - cerebrovascular disease
OT  - differentiation
OT  - neural-like cells
OT  - stem cell therapy
OT  - stroke
OT  - transplantation
EDAT- 2012/09/05 00:00
MHDA- 2012/09/05 00:01
CRDT- 2015/01/28 06:00
PHST- 2012/06/20 00:00 [received]
PHST- 2012/08/06 00:00 [accepted]
PHST- 2015/01/28 06:00 [entrez]
PHST- 2012/09/05 00:00 [pubmed]
PHST- 2012/09/05 00:01 [medline]
AID - 10.3969/j.issn.1673-5374.2012.25.011 [doi]
AID - NRR-7-1992 [pii]
PST - ppublish
SO  - Neural Regen Res. 2012 Sep 5;7(25):1992-9. doi:
      10.3969/j.issn.1673-5374.2012.25.011.


PMID- 22942438
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20211021
IS  - 0008-5286 (Print)
IS  - 0008-5286 (Linking)
VI  - 53
IP  - 3
DP  - 2012 Mar
TI  - Veterinary medical ethics. An ethicist's commentary on UEP/HSUS Agreement.
PG  - 224
FAU - Rollin, Bernard E
AU  - Rollin BE
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Vet J
JT  - The Canadian veterinary journal = La revue veterinaire canadienne
JID - 0004653
SB  - IM
MH  - Animal Welfare/*ethics
MH  - Animals
MH  - Canada
MH  - Humans
MH  - Veterinarians/*ethics/*psychology
MH  - Veterinary Medicine/*ethics
PMC - PMC3280774
EDAT- 2012/09/04 06:00
MHDA- 2012/11/14 06:00
CRDT- 2012/09/04 06:00
PHST- 2012/09/04 06:00 [entrez]
PHST- 2012/09/04 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
PST - ppublish
SO  - Can Vet J. 2012 Mar;53(3):224.


PMID- 22942409
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20120903
IS  - 1930-7837 (Electronic)
IS  - 0022-0337 (Linking)
VI  - 76
IP  - 9
DP  - 2012 Sep
TI  - Gender difference in ethical abilities of dental students.
PG  - 1137-49
AB  - Walker's comprehensive review of claims of gender difference and gender bias in
      moral cognition concluded 1) that gender explains a negligible amount of the
      variability in moral reasoning development, 2) that accumulated evidence does not
      support claims of gender polarity in moral orientations (i.e., an ethic of care
      and an ethic of justice), and 3) that future research should focus on the range
      of psychological processes that engender moral maturity. This study examined
      whether male and female predoctoral dental students who completed an ethics
      curriculum grounded in Rest's comprehensive model of moral functioning differed
      on measures of four capacities: moral sensitivity, moral reasoning, moral
      motivation, and moral implementation. From archival data at the University of
      Minnesota School of Dentistry, data on sixty females and sixty males were
      randomly selected from five cohorts (n=386) who completed an ethics curriculum
      and outcome measures of the four capacities between 1996 and 2000. Gender
      differences were not apparent for a measure of moral sensitivity, but were
      evident for one of the moral reasoning indices, for the responsibility dimension 
      of moral motivation, and for the measure of moral implementation. Implications
      are drawn for future research and for professional ethics education.
FAU - You, Di
AU  - You D
AD  - Department of Psychology and Counseling, Alvernia University, 400 St. Bernardine 
      St., Reading, PA 19607, USA. di.you@alvernia.edu
FAU - Bebeau, Muriel J
AU  - Bebeau MJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Dent Educ
JT  - Journal of dental education
JID - 8000150
SB  - IM
MH  - Analysis of Variance
MH  - Curriculum
MH  - Ethics, Dental/*education
MH  - Female
MH  - Humans
MH  - Judgment
MH  - Male
MH  - Minnesota
MH  - Models, Psychological
MH  - *Moral Development
MH  - Motivation
MH  - *Prejudice
MH  - *Sex Characteristics
MH  - Statistics, Nonparametric
MH  - Students, Dental/*psychology
MH  - Thinking
EDAT- 2012/09/04 06:00
MHDA- 2012/11/14 06:00
CRDT- 2012/09/04 06:00
PHST- 2012/09/04 06:00 [entrez]
PHST- 2012/09/04 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
AID - 76/9/1137 [pii]
PST - ppublish
SO  - J Dent Educ. 2012 Sep;76(9):1137-49.


PMID- 22942407
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20220408
IS  - 1930-7837 (Electronic)
IS  - 0022-0337 (Linking)
VI  - 76
IP  - 9
DP  - 2012 Sep
TI  - Clinical reasoning in dentistry: a conceptual framework for dental education.
PG  - 1116-28
AB  - This study presents a conceptual framework for clinical reasoning by dental
      students. Using a think-aloud method with six vignettes, the researchers
      interviewed eighteen dental students from two stages of training about oral
      health-related problems influenced by biopsychosocial factors. Verbatim
      transcripts of the interviews were analyzed to identify the processes and
      strategies of clinical reasoning used by the students to produce treatment plans.
      The process included 1) rituals to collect information; 2) forward and backward
      reasoning to generate and test clinical hypotheses; 3) pattern recognition from
      integrated scripts of knowledge and experience; and 4) decision trees to assess
      options and outcomes. The process was supplemented by scientific, conditional,
      collaborative, narrative, ethical, pragmatic, and part-whole reasoning
      strategies. Senior students showed a keen awareness of the contextual
      determinants of care and emphasized patients' motivations for treatment. In
      contrast, junior students focused more on problems associated with individual
      teeth as they struggled to integrate the information within each vignette. In
      this article, the processes and strategies for reasoning used by both groups of
      dental students are abstracted and then illustrated by a model of clinical
      reasoning that accommodates the complicated contexts in which clinical problems
      usually arise.
FAU - Khatami, Shiva
AU  - Khatami S
AD  - Department of Orthodontics, College of Dental Medicine, Nova Southeastern
      University, 3200 South University Drive, Fort Lauderdale, FL 33328, USA.
      shiva.khatami@nova.edu
FAU - MacEntee, Michael I
AU  - MacEntee MI
FAU - Pratt, Daniel D
AU  - Pratt DD
FAU - Collins, John B
AU  - Collins JB
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Dent Educ
JT  - Journal of dental education
JID - 8000150
SB  - IM
MH  - Adult
MH  - Decision Making
MH  - Diagnosis, Oral/education
MH  - Education, Dental/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - *Models, Educational
MH  - Patient Care Planning
MH  - Patient Simulation
MH  - Pattern Recognition, Physiological
MH  - Students, Dental/*psychology
MH  - *Thinking
EDAT- 2012/09/04 06:00
MHDA- 2012/11/14 06:00
CRDT- 2012/09/04 06:00
PHST- 2012/09/04 06:00 [entrez]
PHST- 2012/09/04 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
AID - 76/9/1116 [pii]
PST - ppublish
SO  - J Dent Educ. 2012 Sep;76(9):1116-28.


PMID- 22942374
OWN - NLM
STAT- MEDLINE
DCOM- 20140716
LR  - 20211021
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 9
DP  - 2013 Sep
TI  - Is it better to be minimally conscious than vegetative?
PG  - 557-8
LID - 10.1136/medethics-2012-100954 [doi]
FAU - Wilkinson, Dominic
AU  - Wilkinson D
AD  - The Robinson Institute, Women's and Children's Hospital, University of Adelaide, 
      North Adelaide, South Australia, Australia. dominic.wilkinson@adelaide.edu.au
FAU - Savulescu, Julian
AU  - Savulescu J
LA  - eng
GR  - 086041/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120901
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
CIN - J Med Ethics. 2014 Feb;40(2):131-3. PMID: 23625735
MH  - Communication
MH  - Cost of Illness
MH  - Ethics, Medical
MH  - Humans
MH  - Pain
MH  - Persistent Vegetative State/*classification
MH  - *Prognosis
MH  - Quality of Life
MH  - Withholding Treatment/*ethics
OTO - NOTNLM
OT  - Clinical Ethics
EDAT- 2012/09/04 06:00
MHDA- 2014/07/17 06:00
CRDT- 2012/09/04 06:00
PHST- 2012/09/04 06:00 [entrez]
PHST- 2012/09/04 06:00 [pubmed]
PHST- 2014/07/17 06:00 [medline]
AID - medethics-2012-100954 [pii]
AID - 10.1136/medethics-2012-100954 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Sep;39(9):557-8. doi: 10.1136/medethics-2012-100954. Epub 2012
      Sep 1.


PMID- 22942373
OWN - NLM
STAT- MEDLINE
DCOM- 20130304
LR  - 20211021
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 1
DP  - 2013 Jan
TI  - Scientific retractions and corrections related to misconduct findings.
PG  - 46-50
LID - 10.1136/medethics-2012-100766 [doi]
AB  - We examined all 208 closed cases involving official findings of research
      misconduct published by the US Office of Research Integrity from 1992 to 2011 to 
      determine how often scientists mention in a retraction or correction notice that 
      there was an ethical problem with an associated article. 75 of these cases cited 
      at least one published article affected by misconduct for a total of 174
      articles. For 127 of these 174, we found both the article and a retraction or
      correction statement. Since eight of the 127 published statements consisted of
      simply the word 'retracted,' our analysis focused on the remaining 119 for which 
      a more detailed retraction or correction was published. Of these 119 statements, 
      only 41.2% mentioned ethics at all (and only 32.8% named a specific ethical
      problem such as fabrication, falsification or plagiarism), whereas the other
      58.8% described the reason for retraction or correction as error, loss of data or
      replication failure when misconduct was actually at issue. Among the published
      statements in response to an official finding of misconduct (within the time
      frame studied), the proportion that mentioned ethics was significantly higher in 
      recent years than in earlier years, as was the proportion that named a specific
      problem. To promote research integrity, scientific journals should consider
      adopting policies concerning retractions and corrections similar to the
      guidelines developed by the Committee on Publication Ethics. Funding agencies and
      institutions should take steps to ensure that articles affected by misconduct are
      retracted or corrected.
FAU - Resnik, David B
AU  - Resnik DB
AD  - NIEHS, National Institutes of Health, Research Triangle Park, NC 27709, USA.
      resnikd@niehs.nih.gov
FAU - Dinse, Gregg E
AU  - Dinse GE
LA  - eng
GR  - ZIA ES102646-04/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
DEP - 20120901
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Biomedical Research/*ethics/standards
MH  - Conflict of Interest
MH  - *Editorial Policies
MH  - Ethics, Research
MH  - Humans
MH  - *Periodicals as Topic/ethics/standards/trends
MH  - Plagiarism
MH  - Research Support as Topic/ethics
MH  - *Retraction of Publication as Topic
MH  - *Scientific Misconduct/ethics
MH  - United States
MH  - United States Office of Research Integrity
PMC - PMC3525741
MID - NIHMS426037
EDAT- 2012/09/04 06:00
MHDA- 2013/03/05 06:00
CRDT- 2012/09/04 06:00
PHST- 2012/09/04 06:00 [entrez]
PHST- 2012/09/04 06:00 [pubmed]
PHST- 2013/03/05 06:00 [medline]
AID - medethics-2012-100766 [pii]
AID - 10.1136/medethics-2012-100766 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Jan;39(1):46-50. doi: 10.1136/medethics-2012-100766. Epub 2012
      Sep 1.


PMID- 22942153
OWN - NLM
STAT- MEDLINE
DCOM- 20131111
LR  - 20191210
IS  - 1943-4723 (Electronic)
IS  - 0002-8177 (Linking)
VI  - 143
IP  - 9
DP  - 2012 Sep
TI  - What are the ethical implications of using social coupons to expand my patient
      base?
PG  - 1035-7
FAU - Rosato, Richard
AU  - Rosato R
AD  - American Dental Association Council on Ethics, Bylaws and Judicial Affairs, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Am Dent Assoc
JT  - Journal of the American Dental Association (1939)
JID - 7503060
SB  - IM
CIN - J Am Dent Assoc. 2013 Jan;144(1):17-8. PMID: 23283918
CIN - J Am Dent Assoc. 2013 Jan;144(1):18. PMID: 23283919
MH  - Advertising/*ethics
MH  - Dentists/*ethics
MH  - *Ethics, Dental
MH  - Fees, Dental
MH  - Humans
MH  - *Internet
MH  - Marketing of Health Services/ethics
EDAT- 2012/09/04 06:00
MHDA- 2013/11/12 06:00
CRDT- 2012/09/04 06:00
PHST- 2012/09/04 06:00 [entrez]
PHST- 2012/09/04 06:00 [pubmed]
PHST- 2013/11/12 06:00 [medline]
AID - S0002-8177(14)61844-4 [pii]
AID - 10.14219/jada.archive.2012.0336 [doi]
PST - ppublish
SO  - J Am Dent Assoc. 2012 Sep;143(9):1035-7. doi: 10.14219/jada.archive.2012.0336.


PMID- 22942030
OWN - NLM
STAT- MEDLINE
DCOM- 20120927
LR  - 20151119
IS  - 0926-9630 (Print)
IS  - 0926-9630 (Linking)
VI  - 177
DP  - 2012
TI  - Co-production of Health enabled by next generation personal health systems.
PG  - 52-8
AB  - This paper describes the theoretical principles for the establishment of a
      parallel and complementary modality of healthcare delivery - named Coproduction
      of Health (CpH). This service-model activates digital data, information, and
      knowledge about health, healthy choices, and the individuals' health-state and
      computes through personalized models context-aware communication and advice.
      "Lightweight technologies" (smartphones, tablets, application stores) would serve
      as the technology close to the end-users (citizens, patients, clients,
      customers), connecting them with "big data" in conventionally and
      non-conventionally organized data repositories. The CpH modality aims at
      providing synergies between professional healthcare, selfcare, informal care and 
      provides data-fusion from several sources such as health characteristics of
      consumer goods, from sensors, actuators, and health related data-repositories,
      and turns this into "health added value" for the individual. A theoretical
      business model respecting healthcare values, ethics, and legal foundation is also
      sketched out.
FAU - Boye, Niels
AU  - Boye N
AD  - University of Aalborg, Denmark. niels@boye.dk
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Stud Health Technol Inform
JT  - Studies in health technology and informatics
JID - 9214582
MH  - Ambulatory Care/*organization & administration
MH  - Delivery of Health Care/*organization & administration
MH  - *Forecasting
MH  - *Internet
MH  - Precision Medicine/*methods
MH  - Telemedicine/*organization & administration
EDAT- 2012/09/04 06:00
MHDA- 2012/09/28 06:00
CRDT- 2012/09/04 06:00
PHST- 2012/09/04 06:00 [entrez]
PHST- 2012/09/04 06:00 [pubmed]
PHST- 2012/09/28 06:00 [medline]
PST - ppublish
SO  - Stud Health Technol Inform. 2012;177:52-8.


PMID- 22942025
OWN - NLM
STAT- MEDLINE
DCOM- 20120927
LR  - 20151119
IS  - 0926-9630 (Print)
IS  - 0926-9630 (Linking)
VI  - 177
DP  - 2012
TI  - pHealth.
PG  - 3-13
AB  - This chapter deals with my view on pHealth both as president of ICMCC, an
      international foundation dealing with the social, societal and ethical
      implications of the use of ICT in medicine and care and as a cancer survivor.
FAU - Bos, Lodewijk
AU  - Bos L
AD  - E-i-C Health and Technology, Utrecht, the Netherlands. lobos@icmcc.org
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Stud Health Technol Inform
JT  - Studies in health technology and informatics
JID - 9214582
MH  - Ambulatory Care/*trends
MH  - Delivery of Health Care/*trends
MH  - Precision Medicine/*trends
MH  - Telemedicine/*trends
EDAT- 2012/09/04 06:00
MHDA- 2012/09/28 06:00
CRDT- 2012/09/04 06:00
PHST- 2012/09/04 06:00 [entrez]
PHST- 2012/09/04 06:00 [pubmed]
PHST- 2012/09/28 06:00 [medline]
PST - ppublish
SO  - Stud Health Technol Inform. 2012;177:3-13.


PMID- 22941519
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20181202
IS  - 0025-8024 (Print)
IS  - 0025-8024 (Linking)
VI  - 52
IP  - 4
DP  - 2012 Oct
TI  - Minors or suspects? A discussion of the legal and ethical issues surrounding the 
      indefinite storage of DNA collected from children aged 10-18 years on the
      National DNA Database in England and Wales.
PG  - 187-92
LID - 10.1258/msl.2012.011118 [doi]
AB  - There are currently over 250,000 children between the ages of 10 and 18 years who
      have their genetic information stored on the National DNA Database. This paper
      explores the legal and ethical issues surrounding this controversial subject,
      with particular focus on juvenile capacity and the potential results of
      criminalizing young children and adolescents. The implications of the adverse
      legal judgement of the European Court of Human Rights in S and Marper v UK (2008)
      and the violation of Article 8 of the Convention are discussed. The authors have 
      considered the requirement to balance the rights of the individual, particularly 
      those of minors, against the need to protect the public and have compared the
      position in Scotland to that of the rest of the UK. The authors conclude that a
      more ethically acceptable alternative could be the creation of a separate
      forensic database for children aged 10-18 years, set up to safeguard the
      interests of those who have not been convicted of any crime.
FAU - Mansel, Charlotte
AU  - Mansel C
AD  - Imperial College, London, UK.
FAU - Davies, Sharon
AU  - Davies S
LA  - eng
PT  - Journal Article
PT  - Legal Case
DEP - 20120831
PL  - England
TA  - Med Sci Law
JT  - Medicine, science, and the law
JID - 0400721
SB  - IM
MH  - Adolescent
MH  - Child
MH  - *Databases, Nucleic Acid
MH  - England
MH  - Genetic Privacy/ethics/legislation & jurisprudence
MH  - Humans
MH  - Minors/*legislation & jurisprudence
MH  - Specimen Handling/*ethics
MH  - Wales
EDAT- 2012/09/04 06:00
MHDA- 2013/03/13 06:00
CRDT- 2012/09/04 06:00
PHST- 2012/09/04 06:00 [entrez]
PHST- 2012/09/04 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
AID - msl.2012.011118 [pii]
AID - 10.1258/msl.2012.011118 [doi]
PST - ppublish
SO  - Med Sci Law. 2012 Oct;52(4):187-92. doi: 10.1258/msl.2012.011118. Epub 2012 Aug
      31.


PMID- 22941292
OWN - NLM
STAT- MEDLINE
DCOM- 20130208
LR  - 20211021
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 24
IP  - 3
DP  - 2012 Sep
TI  - Education for ethics practice: tailoring curricula to local needs and objectives.
PG  - 227-43
LID - 10.1007/s10730-012-9187-8 [doi]
AB  - Currently, there is no authoritative credentialing process for individuals
      engaged in ethics practice, no accreditation system that sets minimum education
      standards for programs aiming to prepare these individuals for their work, and
      little evidence available that any particular training model is actually
      achieving its pedagogical goals. At the same time, a number of healthcare
      organizations and universities now routinely offer post-graduate programs,
      clinical fellowships and in-house training specifically devised to prepare
      graduates for ethics practice. However, while their numbers appear to be growing,
      information about these programs is limited. In this paper, we describe the
      goals, content and strategies of three educational programs offered in Ontario,
      Canada. These case studies highlight the diversity of ethics education available 
      to those who engage in ethics practice and underscore the need to take this
      variety into account in the development of future education standards that would 
      specify minimally acceptable educational requirements.
FAU - Cline, Cheryl
AU  - Cline C
AD  - Queen's University, Kingston, ON, Canada. clinec@queesu.ca
FAU - Heesters, Ann
AU  - Heesters A
FAU - Secker, Barbara
AU  - Secker B
FAU - Frolic, Andrea
AU  - Frolic A
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - *Bioethical Issues
MH  - Bioethics/*education
MH  - *Curriculum
MH  - Goals
MH  - Humans
MH  - Ontario
MH  - *Professional Practice
EDAT- 2012/09/04 06:00
MHDA- 2013/02/09 06:00
CRDT- 2012/09/04 06:00
PHST- 2012/09/04 06:00 [entrez]
PHST- 2012/09/04 06:00 [pubmed]
PHST- 2013/02/09 06:00 [medline]
AID - 10.1007/s10730-012-9187-8 [doi]
PST - ppublish
SO  - HEC Forum. 2012 Sep;24(3):227-43. doi: 10.1007/s10730-012-9187-8.


PMID- 22941211
OWN - NLM
STAT- MEDLINE
DCOM- 20130510
LR  - 20181202
IS  - 1531-7072 (Electronic)
IS  - 1070-5295 (Linking)
VI  - 18
IP  - 6
DP  - 2012 Dec
TI  - Resident full-time specialists in the ICU: a survivable model?
PG  - 677-82
LID - 10.1097/MCC.0b013e32835909ed [doi]
AB  - PURPOSE OF REVIEW: Intensivists have a professional and personal interest in
      trying to answer whether immediate review of patients by a consultant intensivist
      improves outcomes. Although some advocate in-hospital around-the-clock consultant
      intensivist presence, does the available evidence suggest all ICUs should be
      staffed in such a manner and is such a service sustainable given the shortage of 
      intensivists, potential loss of staff from burnout and cost? RECENT FINDINGS: We 
      present in narrative form the background and recent literature for a consultant
      resident service in terms of the ethical tenets of nonmaleficence, beneficence,
      autonomy and justice. Nonmaleficence - what is the evidence it is bad for
      patients not to provide a resident service? Beneficence - what is the evidence a 
      resident intensivist service is good for patients? Autonomy - is it in
      intensivists' own interests to provide a 24-h service? And justice - is it a
      justifiable use of healthcare resources? SUMMARY: A unified staffing solution
      within a country's different ICUs, let alone between countries, is unlikely. The 
      current evidence does not universally support or justify 24 h/7 days consultant
      intensivist presence. International differences in staffing models and ICU
      structures make direct comparisons difficult and in some circumstances the
      balance may favour 24 h/7 days consultant intensivists.
FAU - Parry-Jones, Jack
AU  - Parry-Jones J
AD  - Aneurin Bevan Health Board, Royal Gwent Hospital, Newport, Wales, UK.
      Jack.parryjones@wales.nhs.uk
FAU - Garland, Allan
AU  - Garland A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Crit Care
JT  - Current opinion in critical care
JID - 9504454
SB  - IM
MH  - Humans
MH  - *Intensive Care Units
MH  - *Internship and Residency
MH  - *Models, Organizational
MH  - *Personnel Staffing and Scheduling
MH  - Referral and Consultation
MH  - *Specialization
MH  - Workforce
EDAT- 2012/09/04 06:00
MHDA- 2013/05/11 06:00
CRDT- 2012/09/04 06:00
PHST- 2012/09/04 06:00 [entrez]
PHST- 2012/09/04 06:00 [pubmed]
PHST- 2013/05/11 06:00 [medline]
AID - 10.1097/MCC.0b013e32835909ed [doi]
PST - ppublish
SO  - Curr Opin Crit Care. 2012 Dec;18(6):677-82. doi: 10.1097/MCC.0b013e32835909ed.


PMID- 22941039
OWN - NLM
STAT- MEDLINE
DCOM- 20130502
LR  - 20151119
IS  - 1432-0851 (Electronic)
IS  - 0340-7004 (Linking)
VI  - 62
IP  - 3
DP  - 2013 Mar
TI  - Concomitant combination of active immunotherapy and carboplatin- or
      paclitaxel-based chemotherapy improves anti-tumor response.
PG  - 455-69
LID - 10.1007/s00262-012-1345-y [doi]
AB  - Recent preclinical evidence substantially supports the successful combination of 
      chemotherapies and active immunotherapy for cancer treatment. These data sustain 
      the effect of sequential combination schemes (vaccine plus chemotherapy or vice
      versa), which could be difficult to implement in clinical practice. Since
      chemotherapy is the standard treatment for most cancers, ethical issues forbid
      its delay and make difficult the evaluation of other treatments such as using an 
      immunotherapeutic agent. Besides, vaccines must be applied as soon as possible to
      advanced cancer patients, in order to give them time to develop an effective
      immune response. Thus, a clinically attractive scenario is the concomitant
      application of treatments. However, little is known about the specific effect of 
      different chemotherapeutic agents when combined with a cancer vaccine in such
      concomitant treatment. In this work, we analyze the influence of high-dose
      carboplatin or paclitaxel in the generation of a specific immune response when
      administered concomitantly with an OVA vaccine. Interestingly, neither
      carboplatin nor paclitaxel affects the humoral and CTL in vivo response generated
      by the vaccine. Moreover, an enhancement of the overall anti-tumor effect was
      observed in animals treated with OVA/CF vaccine combined with cytotoxic drugs.
      Moreover, the effect of the concomitant treatment was tested using a
      tumor-related antigen, the epidermal growth factor (EGF). Animals administered
      with EGF-P64k/Montanide and cytotoxic agents showed an antibody response similar 
      to that from control animals. Therefore, our study suggests that carboplatin and 
      paclitaxel can be concomitantly combined with active immunotherapies in the
      clinical practice of advanced cancer patients.
FAU - Diaz, Y
AU  - Diaz Y
AD  - Systems Biology Department, Center of Molecular Immunology, P.O. Box 16040,
      11600, Havana, Cuba. yildian@yahoo.com
FAU - Tundidor, Y
AU  - Tundidor Y
FAU - Lopez, A
AU  - Lopez A
FAU - Leon, K
AU  - Leon K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120902
PL  - Germany
TA  - Cancer Immunol Immunother
JT  - Cancer immunology, immunotherapy : CII
JID - 8605732
RN  - 0 (Cancer Vaccines)
RN  - 62229-50-9 (Epidermal Growth Factor)
RN  - 9006-59-1 (Ovalbumin)
RN  - BG3F62OND5 (Carboplatin)
RN  - P88XT4IS4D (Paclitaxel)
SB  - IM
MH  - Animals
MH  - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
MH  - Cancer Vaccines/*therapeutic use
MH  - Carboplatin/*administration & dosage
MH  - Combined Modality Therapy
MH  - Epidermal Growth Factor
MH  - Female
MH  - Humans
MH  - Immunotherapy, Active
MH  - Lymphocytes/drug effects
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Neoplasms/*therapy
MH  - Ovalbumin/immunology
MH  - Paclitaxel/*administration & dosage
EDAT- 2012/09/04 06:00
MHDA- 2013/05/03 06:00
CRDT- 2012/09/04 06:00
PHST- 2011/12/06 00:00 [received]
PHST- 2012/08/16 00:00 [accepted]
PHST- 2012/09/04 06:00 [entrez]
PHST- 2012/09/04 06:00 [pubmed]
PHST- 2013/05/03 06:00 [medline]
AID - 10.1007/s00262-012-1345-y [doi]
PST - ppublish
SO  - Cancer Immunol Immunother. 2013 Mar;62(3):455-69. doi: 10.1007/s00262-012-1345-y.
      Epub 2012 Sep 2.


PMID- 22940557
OWN - NLM
STAT- MEDLINE
DCOM- 20140124
LR  - 20220408
IS  - 1879-176X (Electronic)
IS  - 0300-5712 (Linking)
VI  - 41
IP  - 2
DP  - 2013 Feb
TI  - Quantitative light-induced fluorescence (QLF): a tool for early occlusal dental
      caries detection and supporting decision making in vivo.
PG  - 127-32
LID - 10.1016/j.jdent.2012.08.013 [doi]
LID - S0300-5712(12)00231-X [pii]
AB  - OBJECTIVES: This study reports the development and assessment of a novel method
      using quantitative light-induced fluorescence (QLF), to determine whether QLF
      parameters DeltaF and DeltaQ were appropriate for aiding diagnosis and clinical
      decision making of early occlusal mineral loss by comparing QLF analysis with
      actual restorative management. METHODS: Following ethical approval, 46 subjects
      attending a dental teaching hospital were enrolled. White light digital (WL) and 
      QLF images/analyses of 46 unrestored posterior teeth with suspected occlusal
      caries were made after a clinical decision had already been taken to explore
      fissures operatively. WL and QLF imaging/analysis were repeated after initial
      cavity preparation. The type of restorative treatment was determined by the
      supervising clinician independent of any imaging performed. Actual restorative
      management carried out was recorded as fissure sealant/preventive resin
      restoration (F/P) or class I occlusal restoration (Rest.) thus reflecting the
      extent of intervention (=gold standard). All QLF images were analysed
      independently. RESULTS: The results showed statistically significant differences 
      between the two treatment groups DeltaF (p=0.002) (mean 22.60 - F/P and 28.80 -
      Rest.) and DeltaQ (p=0.012) (mean 230.49 - F/P and 348.30 - Rest.). CONCLUSIONS: 
      DeltaF and DeltaQ values may be useful in aiding clinical diagnosis and decision 
      making in relation to the management of early mineral loss and restorative
      intervention of occlusal caries. CLINICAL SIGNIFICANCE: QLF has the potential to 
      be a valuable tool for caries diagnosis in clinical practice.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Alammari, M R
AU  - Alammari MR
AD  - Department of Health Services Research and School of Dentistry, University of
      Liverpool, Liverpool, United Kingdom. malammari@kau.edu.sa
FAU - Smith, P W
AU  - Smith PW
FAU - de Josselin de Jong, E
AU  - de Josselin de Jong E
FAU - Higham, S M
AU  - Higham SM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120830
PL  - England
TA  - J Dent
JT  - Journal of dentistry
JID - 0354422
RN  - 0 (Pit and Fissure Sealants)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Decision Making
MH  - Decision Support Techniques
MH  - Dental Caries/*diagnosis/therapy
MH  - Dental Cavity Preparation/methods
MH  - Dental Fissures/diagnosis/therapy
MH  - Dental Restoration, Permanent/classification/methods
MH  - Early Diagnosis
MH  - Fluorescence
MH  - Humans
MH  - Light
MH  - Middle Aged
MH  - *Patient Care Planning
MH  - Pit and Fissure Sealants/therapeutic use
MH  - Tooth Demineralization/diagnosis/therapy
MH  - Young Adult
EDAT- 2012/09/04 06:00
MHDA- 2014/01/25 06:00
CRDT- 2012/09/04 06:00
PHST- 2012/05/01 00:00 [received]
PHST- 2012/08/19 00:00 [revised]
PHST- 2012/08/22 00:00 [accepted]
PHST- 2012/09/04 06:00 [entrez]
PHST- 2012/09/04 06:00 [pubmed]
PHST- 2014/01/25 06:00 [medline]
AID - S0300-5712(12)00231-X [pii]
AID - 10.1016/j.jdent.2012.08.013 [doi]
PST - ppublish
SO  - J Dent. 2013 Feb;41(2):127-32. doi: 10.1016/j.jdent.2012.08.013. Epub 2012 Aug
      30.


PMID- 22940229
OWN - NLM
STAT- MEDLINE
DCOM- 20130709
LR  - 20220419
IS  - 1872-7727 (Electronic)
IS  - 0720-048X (Linking)
VI  - 82
IP  - 1
DP  - 2013 Jan
TI  - Ultrasound guided percutaneous microwave ablation of benign thyroid nodules:
      safety and imaging follow-up in 222 patients.
PG  - e11-6
LID - 10.1016/j.ejrad.2012.07.020 [doi]
LID - S0720-048X(12)00365-8 [pii]
AB  - OBJECTIVE: Microwave ablation is a minimally invasive technique that has been
      used to treat benign and malignant tumors of liver, lung and kidney. Towards
      thyroid nodules, only a few cases are reported so far. The aim of the study was
      to investigate the effectiveness and safety of ultrasound-guided percutaneous
      microwave ablation in the treatment of benign thyroid nodules with a large
      sample. MATERIALS AND METHODS: A total of 477 benign thyroid nodules in 222
      patients underwent microwave ablation in our department from July 2009 to March
      2012. Microwave ablation was carried out using microwave antenna (16G) under
      local anesthesia. Nodule volume, thyroid function and clinical symptoms were
      evaluated before treatment and at 1, 3, more than 6 months. The study was ethics 
      committee approved and written informed consents were obtained from all patients.
      RESULTS: All thyroid nodules significantly decreased in size after microwave
      ablation. A 6-month follow-up was achieved in 254 of 477 nodules, and the mean
      decrease in the volume of thyroid nodules was from 2.13 +/- 4.42 ml to 0.45 +/-
      0.90 ml, with a mean percent decrease of 0.65 +/- 0.65. A volume-reduction ratio 
      greater than 50% was observed in 82.3% (209/254) of index nodules, and 30.7%
      (78/254) of index nodules disappeared 6-month after the ablation. The treatment
      was well tolerated and no major complications were observed except pain and
      transient voice changes. CONCLUSIONS: Microwave ablation seems to be a safe and
      effective technique for the treatment of benign thyroid nodules. Further
      prospective randomized studies are needed to define the role of the procedure in 
      the treatment of thyroid nodules.
CI  - Crown Copyright (c) 2012. Published by Elsevier Ireland Ltd. All rights reserved.
FAU - Yue, Wenwen
AU  - Yue W
AD  - Binzhou Medical University, #346 Guan-hai Road, Lai-shan, Yantai, Shandong
      264003, PR China.
FAU - Wang, Shurong
AU  - Wang S
FAU - Wang, Bin
AU  - Wang B
FAU - Xu, Qingling
AU  - Xu Q
FAU - Yu, Shoujun
AU  - Yu S
FAU - Yonglin, Zhang
AU  - Yonglin Z
FAU - Wang, Xiju
AU  - Wang X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120830
PL  - Ireland
TA  - Eur J Radiol
JT  - European journal of radiology
JID - 8106411
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Catheter Ablation/*psychology
MH  - China/epidemiology
MH  - Comorbidity
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Microwaves/*therapeutic use
MH  - Middle Aged
MH  - Postoperative Complications/*epidemiology
MH  - Risk Factors
MH  - Surgery, Computer-Assisted/*statistics & numerical data
MH  - Thyroid Nodule/*diagnostic imaging/epidemiology/*surgery
MH  - Treatment Outcome
MH  - Ultrasonography/*statistics & numerical data
MH  - Young Adult
EDAT- 2012/09/04 06:00
MHDA- 2013/07/10 06:00
CRDT- 2012/09/04 06:00
PHST- 2012/04/30 00:00 [received]
PHST- 2012/07/22 00:00 [revised]
PHST- 2012/07/26 00:00 [accepted]
PHST- 2012/09/04 06:00 [entrez]
PHST- 2012/09/04 06:00 [pubmed]
PHST- 2013/07/10 06:00 [medline]
AID - S0720-048X(12)00365-8 [pii]
AID - 10.1016/j.ejrad.2012.07.020 [doi]
PST - ppublish
SO  - Eur J Radiol. 2013 Jan;82(1):e11-6. doi: 10.1016/j.ejrad.2012.07.020. Epub 2012
      Aug 30.


PMID- 22939812
OWN - NLM
STAT- MEDLINE
DCOM- 20130117
LR  - 20131121
IS  - 1879-0828 (Electronic)
IS  - 0953-6205 (Linking)
VI  - 23
IP  - 7
DP  - 2012 Oct
TI  - Mean platelet volume and beta-thromboglobulin levels in familial Mediterranean
      fever: effect of colchicine use?
PG  - 661-4
LID - 10.1016/j.ejim.2012.04.007 [doi]
AB  - BACKGROUND: Many studies have shown that subclinical inflammation persisted
      during remission period of Familial Mediterranean Fever (FMF) patients but long
      term effects of subclinical inflammation in these patients aren't clearly known. 
      Besides, a few of the recent studies revealed that risk of atherosclerosis had
      increased in FMF patients. beta-Thromboglobulin (beta-TG) is considered as a
      sensitive marker of platelet activation. In this study Mean Platelet Volume (MPV)
      and beta-TG levels were evaluated in FMF patients. METHODS: Following the Local
      Ethics Committee's consent, 25 FMF patients were included in the study. Twenty
      eight age and sex matched healthy volunteers were recruited as a control group.
      Lipid profile, inflammatory parameters, hemogram, beta-TG, MPV were assessed.
      Statistical analysis was performed with SPSS for Windows 16.00. RESULTS: Group I 
      consisted of 25 FMF cases (16 females, 9 males; mean age: 35.72 +/- 12.34 years),
      Group II consisted of 28 cases (22 females, 6 males; mean age 31.78 +/- 10.31
      years). There was no statistically significant difference between the groups in
      terms of age and gender distribution, smoking status, total cholesterol,
      triglyceride, LDL and MPV (p>0.05). HDL levels were found to be statistically
      lower in Group I (p:0.04). Median beta-TG levels was significantly higher in
      Group II than Group I (129.50 (range:372.00) ng/mL versus 104.00 (range:212.80)
      ng/mL respectively; p:0.03). CONCLUSION: In this study MPV and beta-TG were
      evaluated for FMF cases and healthy controls, beta-TG levels were found
      significantly lower among patients; we hypothesized that this difference may have
      resulted from the effect of colchicine use on platelet functions.
CI  - Copyright (c) 2012 European Federation of Internal Medicine. Published by
      Elsevier B.V. All rights reserved.
FAU - Abanonu, Gul Babacan
AU  - Abanonu GB
AD  - Department of Internal Medicine, Haydarpasa Numune Training and Research
      Hospital, Istanbul, Turkey. babacangul@hotmail.com
FAU - Daskin, Alper
AU  - Daskin A
FAU - Akdogan, Mehmet Fatih
AU  - Akdogan MF
FAU - Uyar, Seyit
AU  - Uyar S
FAU - Demirtunc, Refik
AU  - Demirtunc R
LA  - eng
PT  - Journal Article
DEP - 20120503
PL  - Netherlands
TA  - Eur J Intern Med
JT  - European journal of internal medicine
JID - 9003220
RN  - 0 (Tubulin Modulators)
RN  - 0 (beta-Thromboglobulin)
RN  - SML2Y3J35T (Colchicine)
SB  - IM
MH  - Adult
MH  - Blood Platelets/*cytology/drug effects/metabolism
MH  - Case-Control Studies
MH  - Cell Size
MH  - Clinical Trials as Topic
MH  - Colchicine/pharmacology
MH  - Familial Mediterranean Fever/*metabolism/physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Platelet Activation/drug effects/physiology
MH  - Retrospective Studies
MH  - Tubulin Modulators/pharmacology
MH  - beta-Thromboglobulin/drug effects/*metabolism
EDAT- 2012/09/04 06:00
MHDA- 2013/01/18 06:00
CRDT- 2012/09/04 06:00
PHST- 2011/05/06 00:00 [received]
PHST- 2012/04/04 00:00 [revised]
PHST- 2012/04/11 00:00 [accepted]
PHST- 2012/09/04 06:00 [entrez]
PHST- 2012/09/04 06:00 [pubmed]
PHST- 2013/01/18 06:00 [medline]
AID - S0953-6205(12)00094-5 [pii]
AID - 10.1016/j.ejim.2012.04.007 [doi]
PST - ppublish
SO  - Eur J Intern Med. 2012 Oct;23(7):661-4. doi: 10.1016/j.ejim.2012.04.007. Epub
      2012 May 3.


PMID- 22939533
OWN - NLM
STAT- MEDLINE
DCOM- 20130502
LR  - 20120903
IS  - 1879-193X (Electronic)
IS  - 0890-4065 (Linking)
VI  - 26
IP  - 4
DP  - 2012 Dec
TI  - Alzheimer's disease and euthanasia.
PG  - 377-85
LID - 10.1016/j.jaging.2012.04.001 [doi]
AB  - Employing the tenets of philosophical materialism, this paper discusses the
      ethical debate surrounding assisted suicide for persons suffering end-stage
      Alzheimer's. It first presents a classification of the dissociative situations
      between "human individual" and "human person". It then moves on to discuss
      challenges to diagnosed persons and their caregivers in relation to the cardinal 
      virtues of Spinozistic ethics--strength of character (fortitudo), firmness
      (animositas) and generosity (generositas). Finally, a number of ideas attached to
      the debate--"right of choice", "death with dignity", "quality of life" and
      "compassion in dying"--are discussed in order to clarify their foundations.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Alvargonzalez, David
AU  - Alvargonzalez D
AD  - Department of Philosophy, Oviedo University, Spain. dalvar@uniovi.es
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120509
PL  - England
TA  - J Aging Stud
JT  - Journal of aging studies
JID - 8916517
SB  - IM
MH  - Aged
MH  - Alzheimer Disease/*diagnosis/psychology
MH  - Caregivers/ethics/legislation & jurisprudence/psychology
MH  - Character
MH  - Depersonalization/diagnosis/psychology
MH  - Dissociative Disorders/diagnosis/psychology
MH  - *Ethics, Medical
MH  - Humans
MH  - Patient Advocacy/ethics/legislation & jurisprudence
MH  - Personal Autonomy
MH  - Personhood
MH  - Quality of Life/legislation & jurisprudence/psychology
MH  - Resilience, Psychological
MH  - Right to Die/ethics/legislation & jurisprudence
MH  - Social Isolation/psychology
MH  - Social Values
MH  - Suicide, Assisted/*ethics/legislation & jurisprudence
MH  - United States
EDAT- 2012/09/04 06:00
MHDA- 2013/05/03 06:00
CRDT- 2012/09/04 06:00
PHST- 2012/01/29 00:00 [received]
PHST- 2012/03/19 00:00 [revised]
PHST- 2012/04/16 00:00 [accepted]
PHST- 2012/09/04 06:00 [entrez]
PHST- 2012/09/04 06:00 [pubmed]
PHST- 2013/05/03 06:00 [medline]
AID - S0890-4065(12)00028-X [pii]
AID - 10.1016/j.jaging.2012.04.001 [doi]
PST - ppublish
SO  - J Aging Stud. 2012 Dec;26(4):377-85. doi: 10.1016/j.jaging.2012.04.001. Epub 2012
      May 9.


PMID- 22939191
OWN - NLM
STAT- MEDLINE
DCOM- 20130711
LR  - 20130201
IS  - 1618-0402 (Electronic)
IS  - 0940-9602 (Linking)
VI  - 195
IP  - 1
DP  - 2013 Jan
TI  - The case of Robert Herrlinger: a unique postwar controversy on the ethics of the 
      anatomical use of bodies of the executed during National Socialism.
PG  - 11-24
LID - 10.1016/j.aanat.2012.07.006 [doi]
LID - S0940-9602(12)00103-3 [pii]
AB  - Historical evidence shows that German anatomists used bodies of executed victims 
      of the National Socialist (NS) regime for anatomical purposes. However, there has
      been little direct information on these anatomists' thoughts and motivations, and
      a public discussion of their activities and ethics only started in the late
      1980s. The present study documents a unique postwar controversy surrounding the
      promotion of the anatomist and medical historian Robert Herrlinger at the
      university of Wurzburg in the late 1950s. This intramural debate had originally
      been mentioned by Goetz Aly in 1987. Herrlinger's files record his career as a
      representative of the discipline of medical history at the university of Wurzburg
      from 1951 to 1960. He never worked there as an active anatomist. When the
      university senate applied for his appointment as full professor in 1957, the
      internist Ernst Wollheim, the pediatrician Joseph Stroder, and the psychiatrist
      Heinrich Scheller strongly opposed this move in a dissenting opinion based on
      Herrlinger's anatomical work on bodies of executed NS-victims. They claimed that 
      he lacked the moral prerequisites required in a teacher of medical ethics. A
      highly controversial debate followed and was remarkable for addressing most of
      the questions of the ethical and political attitudes and responsibilities of
      anatomists in NS-Germany that are still being discussed today and are relevant
      for modern anatomy. It was also significant that Wollheim, Stroder and Scheller
      objected to Herrlinger in his role as a medical historian, not as an anatomist.
      The senate finally rejected the dissenting opinion and Herrlinger was promoted.
CI  - Copyright (c) 2012 Elsevier GmbH. All rights reserved.
FAU - Hildebrandt, Sabine
AU  - Hildebrandt S
AD  - Division of Anatomical Sciences, Department of Medical Education, University of
      Michigan Medical School, Ann Arbor, USA. shilde@umich.edu
LA  - eng
PT  - Biography
PT  - Historical Article
PT  - Journal Article
DEP - 20120809
PL  - Germany
TA  - Ann Anat
JT  - Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische
      Gesellschaft
JID - 100963897
SB  - IM
MH  - Anatomy/*ethics/*history
MH  - Cadaver
MH  - Capital Punishment/history
MH  - Faculty
MH  - Germany
MH  - History, 20th Century
MH  - National Socialism/*history
MH  - Schools, Medical/ethics/history
PS  - Herrlinger R
FPS - Herrlinger, Robert
EDAT- 2012/09/04 06:00
MHDA- 2013/07/13 06:00
CRDT- 2012/09/04 06:00
PHST- 2012/07/10 00:00 [received]
PHST- 2012/07/30 00:00 [revised]
PHST- 2012/07/31 00:00 [accepted]
PHST- 2012/09/04 06:00 [entrez]
PHST- 2012/09/04 06:00 [pubmed]
PHST- 2013/07/13 06:00 [medline]
AID - S0940-9602(12)00103-3 [pii]
AID - 10.1016/j.aanat.2012.07.006 [doi]
PST - ppublish
SO  - Ann Anat. 2013 Jan;195(1):11-24. doi: 10.1016/j.aanat.2012.07.006. Epub 2012 Aug 
      9.


PMID- 22939093
OWN - NLM
STAT- MEDLINE
DCOM- 20130322
LR  - 20130131
IS  - 1469-8161 (Electronic)
IS  - 0031-1820 (Linking)
VI  - 140
IP  - 2
DP  - 2013 Feb
TI  - An alternative to killing? Treatment of reservoir hosts to control a vector and
      pathogen in a susceptible species.
PG  - 247-57
LID - 10.1017/S0031182012001400 [doi]
AB  - Parasite-mediated apparent competition occurs when one species affects another
      through the action of a shared parasite. One way of controlling the parasite in
      the more susceptible host is to manage the reservoir host. Culling can cause
      issues in terms of ethics and biodiversity impacts, therefore we ask: can
      treating, as compared to culling, a wildlife host protect a target species from
      the shared parasite? We used Susceptible Infected Recovered (SIR) models
      parameterized for the tick-borne louping ill virus (LIV) system. Deer are the key
      hosts of the vector (Ixodes ricinus) that transmits LIV to red grouse Lagopus
      lagopus scoticus, causing high mortality. The model was run under scenarios of
      varying acaricide efficacy and deer densities. The model predicted that treating 
      deer can increase grouse density through controlling ticks and LIV, if acaricide 
      efficacies are high and deer densities low. Comparing deer treated with 70%
      acaricide efficacy with a 70% cull rate suggested that treatment may be more
      effective than culling if initial deer densities are high. Our results will help 
      inform tick control policies, optimize the targeting of control methods and
      identify conditions where host management is most likely to succeed. Our approach
      is applicable to other host-vector-pathogen systems.
FAU - Porter, R
AU  - Porter R
AD  - The James Hutton Institute, Craigiebuckler, Aberdeen AB15 8QH, UK.
FAU - Norman, R A
AU  - Norman RA
FAU - Gilbert, L
AU  - Gilbert L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120903
PL  - England
TA  - Parasitology
JT  - Parasitology
JID - 0401121
RN  - 0 (Acaricides)
SB  - IM
MH  - Acaricides/*therapeutic use
MH  - Animals
MH  - Arachnid Vectors/physiology/virology
MH  - Bird Diseases/epidemiology/parasitology/*prevention & control/virology
MH  - *Disease Reservoirs/parasitology/virology
MH  - Encephalitis Viruses, Tick-Borne/physiology
MH  - Encephalitis, Tick-Borne/*prevention & control/transmission
MH  - Galliformes/parasitology/virology
MH  - Ixodes/*physiology/virology
MH  - *Models, Biological
MH  - Population Density
MH  - Tick Infestations/*drug therapy/prevention & control/transmission/virology
MH  - Time Factors
EDAT- 2012/09/04 06:00
MHDA- 2013/03/23 06:00
CRDT- 2012/09/04 06:00
PHST- 2012/09/04 06:00 [entrez]
PHST- 2012/09/04 06:00 [pubmed]
PHST- 2013/03/23 06:00 [medline]
AID - S0031182012001400 [pii]
AID - 10.1017/S0031182012001400 [doi]
PST - ppublish
SO  - Parasitology. 2013 Feb;140(2):247-57. doi: 10.1017/S0031182012001400. Epub 2012
      Sep 3.


PMID- 22938490
OWN - NLM
STAT- MEDLINE
DCOM- 20130227
LR  - 20220317
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Linking)
VI  - 13
IP  - 6
DP  - 2012
TI  - Evaluation of chromosomal alteration in electrical workers occupationally exposed
      to low frequency of electro magnetic field (EMFs) in Coimbatore population,
      India.
PG  - 2961-6
AB  - Extremely low frequency electro magnetic fields (EMFs) have been classified as
      possibly carcinogenic to humans by the International Agency for Research on
      Cancer. An increased number of chromosomal alterations in peripheral lymphocytes 
      are correlated with elevated incidence of cancer. The aim of the present study
      was to assess occupationally induced chromosomal damage in EMF workers exposed to
      low levels of radiation. We used conventional metaphase chromosome aberration
      (CA) analysis and the micronucleus (MN) assay as biological indicators of non
      ionizing radiation exposure. In the present study totally 70 subjects were
      selected including 50 exposed and 20 controls. Informed written consent was
      obtained from all participants and the study was performed in accordance with the
      Declaration of Helsinki and the approval of the local ethical committee. A higher
      degree of CA and MN was observed in exposed subjects compared to controls, the
      frequency of CA being significantly enhanced with long years of exposure
      (P<0.05). Moreover increase in CA and MN with age was noted in both exposed
      subjects and controls, but was significantly greater in the former. The results
      of this study demonstrated that a significant induction of cytogenetic damage in 
      peripheral lymphocytes of workers occupationally exposed to EMFs in electric
      transformer and distribution stations. In conclusion, our findings suggest that
      EMFs possess genotoxic capability, as measured by CA and MN assays; CA analysis
      appeared more sensitive than other cytogenetic end-points. It can be concluded
      that chronic occupational exposure to EMFs may lead to an increased risk of
      genetic damage among electrical workers.
FAU - Balamuralikrishnan, Balasubramanian
AU  - Balamuralikrishnan B
AD  - Human Genetics Laboratory, School of Life Sciences, Bharathiar University, Tamil 
      Nadu, India. geneticbala@yahoo.co.in
FAU - Balachandar, Vellingiri
AU  - Balachandar V
FAU - Kumar, Shanmugam Suresh
AU  - Kumar SS
FAU - Stalin, Nattan
AU  - Stalin N
FAU - Varsha, Prakash
AU  - Varsha P
FAU - Devi, Subramaniam Mohana
AU  - Devi SM
FAU - Arun, Meyyazhagan
AU  - Arun M
FAU - Manikantan, Pappuswamy
AU  - Manikantan P
FAU - Venkatesan, Chinnakulandhai
AU  - Venkatesan C
FAU - Sasikala, Keshavarao
AU  - Sasikala K
FAU - Dharwadkar, Shahnaz N
AU  - Dharwadkar SN
LA  - eng
PT  - Journal Article
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
SB  - IM
MH  - Adult
MH  - *Chromosome Aberrations
MH  - Electromagnetic Fields/*adverse effects
MH  - Humans
MH  - India
MH  - Lymphocytes/*radiation effects
MH  - Micronucleus Tests
MH  - Middle Aged
MH  - *Occupational Exposure
EDAT- 2012/09/04 06:00
MHDA- 2013/02/28 06:00
CRDT- 2012/09/04 06:00
PHST- 2012/09/04 06:00 [entrez]
PHST- 2012/09/04 06:00 [pubmed]
PHST- 2013/02/28 06:00 [medline]
AID - 10.7314/apjcp.2012.13.6.2961 [doi]
PST - ppublish
SO  - Asian Pac J Cancer Prev. 2012;13(6):2961-6. doi: 10.7314/apjcp.2012.13.6.2961.


PMID- 22937795
OWN - NLM
STAT- MEDLINE
DCOM- 20130131
LR  - 20211021
IS  - 1756-0500 (Electronic)
IS  - 1756-0500 (Linking)
VI  - 5
DP  - 2012 Sep 1
TI  - Non-invasive prenatal diagnostic test accuracy for fetal sex using cell-free DNA 
      a review and meta-analysis.
PG  - 476
LID - 10.1186/1756-0500-5-476 [doi]
AB  - BACKGROUND: Cell-free fetal DNA (cffDNA) can be detected in maternal blood during
      pregnancy, opening the possibility of early non-invasive prenatal diagnosis for a
      variety of genetic conditions. Since 1997, many studies have examined the
      accuracy of prenatal fetal sex determination using cffDNA, particularly for
      pregnancies at risk of an X-linked condition. Here we report a review and
      meta-analysis of the published literature to evaluate the use of cffDNA for
      prenatal determination (diagnosis) of fetal sex. We applied a sensitive search of
      multiple bibliographic databases including PubMed (MEDLINE), EMBASE, the Cochrane
      library and Web of Science. RESULTS: Ninety studies, incorporating 9,965
      pregnancies and 10,587 fetal sex results met our inclusion criteria. Overall mean
      sensitivity was 96.6% (95% credible interval 95.2% to 97.7%) and mean specificity
      was 98.9% (95% CI = 98.1% to 99.4%). These results vary very little with
      trimester or week of testing, indicating that the performance of the test is
      reliably high. CONCLUSIONS: Based on this review and meta-analysis we conclude
      that fetal sex can be determined with a high level of accuracy by analyzing
      cffDNA. Using cffDNA in prenatal diagnosis to replace or complement existing
      invasive methods can remove or reduce the risk of miscarriage. Future work should
      concentrate on the economic and ethical considerations of implementing an early
      non-invasive test for fetal sex.
FAU - Wright, Caroline F
AU  - Wright CF
AD  - PHG Foundation, 2 Worts Causeway, Cambridge, UK.
FAU - Wei, Yinghui
AU  - Wei Y
FAU - Higgins, Julian P T
AU  - Higgins JP
FAU - Sagoo, Gurdeep S
AU  - Sagoo GS
LA  - eng
GR  - MC_U105285807/MRC_/Medical Research Council/United Kingdom
GR  - U.1052.00.011/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120901
PL  - England
TA  - BMC Res Notes
JT  - BMC research notes
JID - 101462768
RN  - 0 (Biomarkers)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Biomarkers/blood
MH  - Cell-Free System
MH  - DNA/*blood
MH  - Female
MH  - *Genetic Testing
MH  - Gestational Age
MH  - Humans
MH  - Male
MH  - Predictive Value of Tests
MH  - Pregnancy
MH  - Pregnancy Trimesters
MH  - Prenatal Diagnosis/*methods
MH  - Reproducibility of Results
MH  - Sex Determination Analysis/*methods
PMC - PMC3444439
EDAT- 2012/09/04 06:00
MHDA- 2013/02/01 06:00
CRDT- 2012/09/04 06:00
PHST- 2012/03/09 00:00 [received]
PHST- 2012/08/14 00:00 [accepted]
PHST- 2012/09/04 06:00 [entrez]
PHST- 2012/09/04 06:00 [pubmed]
PHST- 2013/02/01 06:00 [medline]
AID - 1756-0500-5-476 [pii]
AID - 10.1186/1756-0500-5-476 [doi]
PST - epublish
SO  - BMC Res Notes. 2012 Sep 1;5:476. doi: 10.1186/1756-0500-5-476.


PMID- 22937787
OWN - NLM
STAT- MEDLINE
DCOM- 20130730
LR  - 20121214
IS  - 1432-2277 (Electronic)
IS  - 0934-0874 (Linking)
VI  - 26
IP  - 1
DP  - 2013 Jan
TI  - Is there an advantage of living over deceased donation in liver transplantation?
PG  - 11-9
LID - 10.1111/j.1432-2277.2012.01550.x [doi]
AB  - Living donor liver transplantation (LDLT) is a well-established strategy to
      decrease the mortality in the waiting list and recent studies have demonstrated
      its value even in patients with low MELD score. However, LDLT is still under a
      high level of scrutiny because of its technical complexity and ethical challenges
      as demonstrated by a decline in the number of procedures performed in the last
      decade in Western Countries. Many aspects make LDLT different from deceased donor
      liver transplantation, including timing of transplantation, procedure-related
      complications as well as immunological factors that may affect graft outcomes.
      Our review suggests that in selected cases, LDLT offers significant advantages
      over deceased donor liver transplantation and should be used more liberally.
CI  - (c) 2012 The Authors Transplant International (c) 2012 European Society for Organ
      Transplantation.
FAU - Quintini, Cristiano
AU  - Quintini C
AD  - Liver Transplant Program, Cleveland Clinic, Cleveland, OH, USA.
FAU - Hashimoto, Koji
AU  - Hashimoto K
FAU - Uso, Teresa Diago
AU  - Uso TD
FAU - Miller, Charles
AU  - Miller C
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120902
PL  - Switzerland
TA  - Transpl Int
JT  - Transplant international : official journal of the European Society for Organ
      Transplantation
JID - 8908516
SB  - IM
MH  - Carcinoma, Hepatocellular/surgery
MH  - Graft Rejection
MH  - Hepatitis C/complications
MH  - Humans
MH  - Liver Failure, Acute/surgery
MH  - Liver Neoplasms/surgery
MH  - *Liver Transplantation/methods
MH  - *Living Donors
EDAT- 2012/09/04 06:00
MHDA- 2013/07/31 06:00
CRDT- 2012/09/04 06:00
PHST- 2012/09/04 06:00 [entrez]
PHST- 2012/09/04 06:00 [pubmed]
PHST- 2013/07/31 06:00 [medline]
AID - 10.1111/j.1432-2277.2012.01550.x [doi]
PST - ppublish
SO  - Transpl Int. 2013 Jan;26(1):11-9. doi: 10.1111/j.1432-2277.2012.01550.x. Epub
      2012 Sep 2.


PMID- 22937765
OWN - NLM
STAT- MEDLINE
DCOM- 20130117
LR  - 20211021
IS  - 1471-2407 (Electronic)
IS  - 1471-2407 (Linking)
VI  - 12
DP  - 2012 Sep 3
TI  - Health-related quality of life among colorectal cancer patients in Malaysia: a
      study protocol.
PG  - 384
LID - 10.1186/1471-2407-12-384 [doi]
AB  - BACKGROUND: Colorectal cancer is a major public health problem in Malaysia.
      However, it is also one of the most treatable cancers, resulting in significant
      numbers of survivors. Therefore, the impact of surviving treatment for colorectal
      cancer on health related quality of life is important for the patients,
      clinicians and policy makers, and may differ in different cultures and
      populations. The aim of this study was to validate the Malaysian versions of the 
      European Organization for Research and Treatment of Cancer quality of life
      instruments among colorectal cancers patients. METHODS/DESIGN: This is a cross
      sectional multi centre study. Three hospitals were included, the University of
      Malaya Medical Centre, the Universiti Kebangsaan Malaysia Medical Centre and
      Hospital Tuanku Jaafar Seremban. Malaysian citizens and permanent residence were 
      studied and demographic and clinical information obtained from hospital records. 
      The European Organization for Research and Treatment of Cancer Quality of life
      Core 30, colorectal cancer CR29, and the colorectal cancer liver metastasis LMC
      21 were used and an observer assessment of performance obtained with the
      Karnofsky Performance Scale. Questionnaires were translated into three most
      commonly spoken languages in Malaysia (Bahasa Malaysia, Chinese and Tamil), then 
      administered, scored and analyzed following the developers' guidelines. Ethical
      approval was obtained from the participating centres. Tests of reliability and
      validity were performed to examine the validity of these instruments. CONCLUSION:
      The result of pilot testing shows that the use of the Malaysian versions of EORTC
      QLQ C30, CR29 instruments is feasible in our sample of colorectal cancer
      patients. Instructions for completion as well as questions were well understood
      except the questions on the overall quality of life, overall health status and
      sexual activity. Thus we anticipate obtaining good psychometric properties for
      the instruments at the end of the study.
FAU - Magaji, Bello Arkilla
AU  - Magaji BA
AD  - Julius Centre University of Malaya, Department of Social & Preventive Medicine,
      Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
      drmagaji@siswa.um.edu.my
FAU - Moy, Foong Ming
AU  - Moy FM
FAU - Roslani, April Camilla
AU  - Roslani AC
FAU - Sagap, Ismail
AU  - Sagap I
FAU - Zakaria, Jasiah
AU  - Zakaria J
FAU - Blazeby, Jane M
AU  - Blazeby JM
FAU - Law, Chee Wei
AU  - Law CW
LA  - eng
GR  - G0800800/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20120903
PL  - England
TA  - BMC Cancer
JT  - BMC cancer
JID - 100967800
SB  - IM
MH  - Aged
MH  - Clinical Protocols
MH  - Colorectal Neoplasms/*epidemiology
MH  - Cross-Sectional Studies
MH  - Female
MH  - *Health Status
MH  - Humans
MH  - Malaysia/epidemiology
MH  - Male
MH  - Middle Aged
MH  - *Quality of Life
MH  - Surveys and Questionnaires
PMC - PMC3443003
EDAT- 2012/09/04 06:00
MHDA- 2013/01/18 06:00
CRDT- 2012/09/04 06:00
PHST- 2011/10/03 00:00 [received]
PHST- 2012/08/27 00:00 [accepted]
PHST- 2012/09/04 06:00 [entrez]
PHST- 2012/09/04 06:00 [pubmed]
PHST- 2013/01/18 06:00 [medline]
AID - 1471-2407-12-384 [pii]
AID - 10.1186/1471-2407-12-384 [doi]
PST - epublish
SO  - BMC Cancer. 2012 Sep 3;12:384. doi: 10.1186/1471-2407-12-384.


PMID- 22937194
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20211021
IS  - 1937-8688 (Electronic)
VI  - 12
DP  - 2012
TI  - Evaluation of medical consultation letters at King Fahd Hospital, Al Hufuf, Saudi
      Arabia.
PG  - 54
AB  - BACKGROUND: In surgical wards, it is of paramount importance to communicate with 
      other health care providers, mostly physicians, referring patients to them for
      their consultation on any health conditions that affect pre-operative, operative 
      and post-operative patient care. The purposes of this investigation were to
      assess the appropriateness of physician responses in medical consultation reports
      and compare physician responses when using these reports from different levels of
      health care providers. METHODS: This study was conducted in Al-Hufuf, Saudi
      Arabia. The researchers evaluated all the surgical consultation letters in the
      files during the period between March 2010 and March 2011. From the explored 234 
      files, only 200 consultation letters were chosen as there was a referral data
      plus consultation data in the same file. We evaluated the quality of consultation
      report included the ethical concerns towards colleagues and patient,
      consideration of patient safety in all opinions, comprehensive pertinent
      scientific information, addressing the patient's medical condition with putting
      possible differential diagnosis, conclusion and precise management plans
      suggested. RESULTS: The results showed that the specialists' consultation letters
      had the highest percentage of fulfillment of all the six items in the
      consultation report. There is no uniform existing consultation report form.
      CONCLUSION: Specialist form showed the highest number of mentioning the
      diagnosis. Consultant form showed the highest number of mentioning the concise
      aim of referral. The highest percentage of all categories mentioned all items in 
      consultation report with a good level were the specialists.
FAU - Al Wadaani, Hamed Abd Allah
AU  - Al Wadaani HA
AD  - College of Medicine, King Faisal University, Saudi Arabia.
FAU - Hassan Balaha, Magdy
AU  - Hassan Balaha M
LA  - eng
PT  - Journal Article
DEP - 20120629
PL  - Uganda
TA  - Pan Afr Med J
JT  - The Pan African medical journal
JID - 101517926
SB  - IM
MH  - Hospitals
MH  - Humans
MH  - Interdisciplinary Communication
MH  - Medical Records/*standards
MH  - Referral and Consultation/*standards
MH  - Saudi Arabia
PMC - PMC3428174
OTO - NOTNLM
OT  - Medical consultation
OT  - Saudi Arabia
OT  - referring patients
EDAT- 2012/09/01 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/09/01 06:00
PHST- 2011/12/07 00:00 [received]
PHST- 2012/06/23 00:00 [accepted]
PHST- 2012/09/01 06:00 [entrez]
PHST- 2012/09/01 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
PST - ppublish
SO  - Pan Afr Med J. 2012;12:54. Epub 2012 Jun 29.


PMID- 22936822
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20220129
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 4
DP  - 2012
TI  - The Olympic Regeneration in East London (ORiEL) study: protocol for a prospective
      controlled quasi-experiment to evaluate the impact of urban regeneration on young
      people and their families.
LID - 10.1136/bmjopen-2012-001840 [doi]
LID - e001840 [pii]
AB  - INTRODUCTION: Recent systematic reviews suggest that there is a dearth of
      evidence on the effectiveness of large-scale urban regeneration programmes in
      improving health and well-being and alleviating health inequalities. The
      development of the Olympic Park in Stratford for the London 2012 Olympic and
      Paralympic Games provides the opportunity to take advantage of a natural
      experiment to examine the impact of large-scale urban regeneration on the health 
      and well-being of young people and their families. DESIGN AND METHODS: A
      prospective school-based survey of adolescents (11-12 years) with parent data
      collected through face-to-face interviews at home. Adolescents will be recruited 
      from six randomly selected schools in an area receiving large-scale urban
      regeneration (London Borough of Newham) and compared with adolescents in 18
      schools in three comparison areas with no equivalent regeneration (London
      Boroughs of Tower Hamlets, Hackney and Barking & Dagenham). Baseline data will be
      completed prior to the start of the London Olympics (July 2012) with follow-up at
      6 and 18 months postintervention. Primary outcomes are: pre-post change in
      adolescent and parent mental health and well-being, physical activity and
      parental employment status. Secondary outcomes include: pre-post change in social
      cohesion, smoking, alcohol use, diet and body mass index. The study will account 
      for individual and environmental contextual effects in evaluating changes to
      identified outcomes. A nested longitudinal qualitative study will explore
      families' experiences of regeneration in order to unpack the process by which
      regeneration impacts on health and well-being. ETHICS AND DISSEMINATION: The
      study has approval from Queen Mary University of London Ethics Committee
      (QMREC2011/40), the Association of Directors of Children's Services (RGE110927)
      and the London Boroughs Research Governance Framework (CERGF113). Fieldworkers
      have had advanced Criminal Records Bureau clearance. Findings will be
      disseminated through peer-reviewed publications, national and international
      conferences, through participating schools and the study website
      (http://www.orielproject.co.uk).
FAU - Smith, Neil R
AU  - Smith NR
AD  - Centre for Psychiatry, Wolfson Institute of Preventive Medicine, Barts and The
      London School of Medicine and Dentistry, Queen Mary University of London, London,
      UK.
FAU - Clark, Charlotte
AU  - Clark C
FAU - Fahy, Amanda E
AU  - Fahy AE
FAU - Tharmaratnam, Vanathi
AU  - Tharmaratnam V
FAU - Lewis, Daniel J
AU  - Lewis DJ
FAU - Thompson, Claire
AU  - Thompson C
FAU - Renton, Adrian
AU  - Renton A
FAU - Moore, Derek G
AU  - Moore DG
FAU - Bhui, Kamaldeep S
AU  - Bhui KS
FAU - Taylor, Stephanie J C
AU  - Taylor SJ
FAU - Eldridge, Sandra
AU  - Eldridge S
FAU - Petticrew, Mark
AU  - Petticrew M
FAU - Greenhalgh, Tricia
AU  - Greenhalgh T
FAU - Stansfeld, Stephen A
AU  - Stansfeld SA
FAU - Cummins, Steven
AU  - Cummins S
LA  - eng
GR  - 09/3005/09/DH_/Department of Health/United Kingdom
GR  - PHR/09/3005/09/DH_/Department of Health/United Kingdom
GR  - SRF-2010-03-05/DH_/Department of Health/United Kingdom
PT  - Journal Article
DEP - 20120829
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3432843
EDAT- 2012/09/01 06:00
MHDA- 2012/09/01 06:01
CRDT- 2012/09/01 06:00
PHST- 2012/09/01 06:00 [entrez]
PHST- 2012/09/01 06:00 [pubmed]
PHST- 2012/09/01 06:01 [medline]
AID - bmjopen-2012-001840 [pii]
AID - 10.1136/bmjopen-2012-001840 [doi]
PST - epublish
SO  - BMJ Open. 2012 Aug 29;2(4). pii: bmjopen-2012-001840. doi:
      10.1136/bmjopen-2012-001840. Print 2012.


PMID- 22936555
OWN - NLM
STAT- MEDLINE
DCOM- 20130213
LR  - 20120831
IS  - 0015-5659 (Print)
IS  - 0015-5659 (Linking)
VI  - 71
IP  - 3
DP  - 2012 Aug
TI  - Median nerve thenar motor branch anatomical variations.
PG  - 183-6
AB  - BACKGROUND: The aim of this study was to determine the prevalence of the
      different types of median nerve thenar motor branch and to compare them with
      literature data. MATERIAL AND METHODS: This study was conducted using median
      nerves dissected from cadavers stored in a 10% solution of formaldehyde at the
      Department of Anatomy of Jagiellonian University Medical College (JUMC) and
      cadavers from the Department of Forensic Medicine JUMC. The research protocol was
      approved by the Jagiellonian University Ethics Committee (registry KBET/
      /209/B/2002). RESULTS: The studied group comprised 8 (26.7%) women and 22 men
      (age between 23 and 92 years), yielding a total of 60 thenar motor branches (30
      right vs. 30 left). Forty-seven (78.3%) nerves were classified as
      extraligamentous, 12 (20%) were subligamentous, and 1 (1.7%) was
      transligamentous. As for the side of origin of the thenar motor branch, in 45
      (75%) cases it was the radial side and in 2 (3.33%) cases it was the ulnar side. 
      CONCLUSIONS: The obtained results confirm that the extraligamentous type of
      thenar motor branch is the most common and that the ulnar origin of the thenar
      motor branch is the rarest.
FAU - Mizia, E
AU  - Mizia E
AD  - Department of Anatomy, Jagiellonian University Medical College, Krakow, Poland.
FAU - Tomaszewski, K A
AU  - Tomaszewski KA
FAU - Goncerz, G
AU  - Goncerz G
FAU - Kurzydlo, W
AU  - Kurzydlo W
FAU - Walocha, J
AU  - Walocha J
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PL  - Poland
TA  - Folia Morphol (Warsz)
JT  - Folia morphologica
JID - 0374620
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - Male
MH  - Median Nerve/*anatomy & histology
MH  - Middle Aged
EDAT- 2012/09/01 06:00
MHDA- 2013/02/14 06:00
CRDT- 2012/09/01 06:00
PHST- 2012/09/01 06:00 [entrez]
PHST- 2012/09/01 06:00 [pubmed]
PHST- 2013/02/14 06:00 [medline]
PST - ppublish
SO  - Folia Morphol (Warsz). 2012 Aug;71(3):183-6.


PMID- 22936548
OWN - NLM
STAT- MEDLINE
DCOM- 20130213
LR  - 20140731
IS  - 0015-5659 (Print)
IS  - 0015-5659 (Linking)
VI  - 71
IP  - 3
DP  - 2012 Aug
TI  - Vascular architecture of the human uterine cervix, as assessed in light- and
      scanning electron microscopy.
PG  - 142-7
AB  - BACKGROUND: The aim of this study was to visualise and describe the vasculature
      of the human uterine cervix. MATERIAL AND METHODS: The material for this study
      was obtained from women (age between 20 to 45 years) during autopsy. The material
      was collected not later than 24 h post-mortem. This study was performed using
      uteri from cadavers of menstruating nulliparas (33 uteri) and menstruating
      multiparas (27 uteri). Collected uteri were perfused via the afferent vessels
      with Mercox resin (for corrosion-casting and SEM assessment) or acrylic paint
      solution (light microscopy assessment). The research protocol was approved by the
      Jagiellonian University Ethics Committee (registry KBET/121/8/2007). RESULTS: In 
      all cases bilateral cervical branches (1-4), originating from the uterine artery,
      were found. Both in the vaginal and supravaginal parts of the cervix, four
      distinct vascular zones were found. In the pericanalar zone ran small veins,
      responsible for draining the mucosal capillaries. Both in the muscular layer, as 
      well as in the pericanalar zone, arterioles, and venules passed close to each
      other, often adjoining. CONCLUSIONS: This study does not confirm the existence of
      a single cervicovaginal artery, but shows that the vascular supply of the cervix 
      comes from several vessels. It also introduces the idea of two systems,
      responsible for draining blood from the mucosal capillaries. Neither assessment
      in light microscopy nor in SEM revealed any differences between multiparas and
      nulliparas, regarding the vascular architecture of the cervix.
FAU - Bereza, T
AU  - Bereza T
AD  - Department of Anatomy, Jagiellonian University Medical College, Krakow, Poland.
FAU - Tomaszewski, K A
AU  - Tomaszewski KA
FAU - Walocha, J
AU  - Walocha J
FAU - Mizia, E
AU  - Mizia E
FAU - Bachul, P
AU  - Bachul P
FAU - Chmielewski, P
AU  - Chmielewski P
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Poland
TA  - Folia Morphol (Warsz)
JT  - Folia morphologica
JID - 0374620
SB  - IM
MH  - Adult
MH  - Capillaries/ultrastructure
MH  - Cervix Uteri/*blood supply/*ultrastructure
MH  - Female
MH  - Humans
MH  - Microscopy, Electron, Scanning
MH  - Middle Aged
MH  - Myometrium/*blood supply/*ultrastructure
MH  - Veins/ultrastructure
EDAT- 2012/09/01 06:00
MHDA- 2013/02/14 06:00
CRDT- 2012/09/01 06:00
PHST- 2012/09/01 06:00 [entrez]
PHST- 2012/09/01 06:00 [pubmed]
PHST- 2013/02/14 06:00 [medline]
PST - ppublish
SO  - Folia Morphol (Warsz). 2012 Aug;71(3):142-7.


PMID- 22936533
OWN - NLM
STAT- MEDLINE
DCOM- 20131030
LR  - 20161125
IS  - 1758-5341 (Electronic)
IS  - 0016-9013 (Linking)
VI  - 53
IP  - 3
DP  - 2013 Jun
TI  - Renovating Alzheimer's: "constructive" reflections on the new clinical and
      research diagnostic guidelines.
PG  - 378-87
LID - 10.1093/geront/gns096 [doi]
AB  - The development of disease concepts for conditions such as Alzheimer's disease
      (AD) is an ongoing social process that evolves over time. The biomedical paradigm
      about AD that has informed our culture's understanding of brain aging for the
      past several decades is currently undergoing a major and timely renovation in the
      early 21st century. This evolution is reflected in new guidelines issued by the
      National Institute on Aging and Alzheimer's Association (NIA/AA) for the
      diagnosis of AD and related conditions that aim at helping researchers identify
      and eventually treat AD in its presymptomatic stages. The purpose of this article
      is to offer the scientific, clinical, and ethics communities a critical analysis 
      of the implications of proposed guidelines and prompt deeper reflection about the
      lessons learned from these new efforts both in terms of their actual content and 
      the cultural context in which they were issued and will be used. From a
      social-constructivist perspective, we explore the gradual 100-year evolution of
      AD and summarize the proposed NIA/AA guidelines within this historical context,
      enumerating what we see as their main benefits and limitations. We then consider 
      the potential implications of these guidelines in the clinical setting, and
      explore shifts in our cultural paradigm about brain aging that might be
      engendered by the logic of the guidelines.
FAU - George, Daniel R
AU  - George DR
AD  - Department of Humanities, Penn State College of Medicine, 500 University Drive,
      Hershey, PA 17033, USA. drg21@psu.edu
FAU - Qualls, Sara H
AU  - Qualls SH
FAU - Camp, Cameron J
AU  - Camp CJ
FAU - Whitehouse, Peter J
AU  - Whitehouse PJ
LA  - eng
PT  - Journal Article
DEP - 20120830
PL  - United States
TA  - Gerontologist
JT  - The Gerontologist
JID - 0375327
RN  - 0 (Biomarkers)
SB  - IM
MH  - Alzheimer Disease/*diagnosis
MH  - Biomarkers
MH  - Cognitive Dysfunction/*diagnosis
MH  - Dementia/*diagnosis
MH  - Humans
MH  - *Practice Guidelines as Topic
EDAT- 2012/09/01 06:00
MHDA- 2013/10/31 06:00
CRDT- 2012/09/01 06:00
PHST- 2012/09/01 06:00 [entrez]
PHST- 2012/09/01 06:00 [pubmed]
PHST- 2013/10/31 06:00 [medline]
AID - gns096 [pii]
AID - 10.1093/geront/gns096 [doi]
PST - ppublish
SO  - Gerontologist. 2013 Jun;53(3):378-87. doi: 10.1093/geront/gns096. Epub 2012 Aug
      30.


PMID- 22936484
OWN - NLM
STAT- MEDLINE
DCOM- 20130131
LR  - 20160707
IS  - 1437-1588 (Electronic)
IS  - 1436-9990 (Linking)
VI  - 55
IP  - 9
DP  - 2012 Sep
TI  - [The role of caregivers in health care. Historical backgrounds and current
      conflict situations].
PG  - 1161-7
LID - 10.1007/s00103-012-1540-1 [doi]
AB  - As a result of recent demographic developments, there has been an increased
      demand for high-quality health care. Among the various health professions,
      caregiving represents the largest professional group, numbering approximately
      820,000 caregivers. Despite its size, this group is failing to meet basic
      conditions in line with international standards that secure adequate care. This
      failing is primarily due to the special path that Germany took regarding
      healthcare at the end of the nineteenth century and on which it continues to this
      day. It manifests itself in a heteronomy to which the professional group is
      permanently subjected by lobbies and policies that view health care from a
      perspective whose primary aim is to reduce unemployment. The present lack of
      organization of caregivers has frustrated their political assertiveness; and not 
      least because of this, many caregivers leave the profession early. The profession
      itself is grappling with its professional identity. The development of expert
      standards, research into care, ethical reflections, as well as the struggle for
      common professional training are positive signs in this ongoing debate and are
      reflected in the positive feedback received from patients. The interdisciplinary 
      dialogue between caregivers and physicians is in need of improvement. The first
      signs of progress are evident within the framework of health care ethics
      committees. This dialogue would certainly benefit both the professional group as 
      well as the patients.
FAU - Hofmann, I
AU  - Hofmann I
AD  - info@irmgard-hofmann.de
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Die Rolle der Pflege im Gesundheitswesen. Historische Hintergrunde und heutige
      Konfliktkonstellationen.
PL  - Germany
TA  - Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
JT  - Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
JID - 101181368
SB  - IM
MH  - Caregivers/*trends
MH  - Delivery of Health Care/*trends
MH  - Germany
MH  - Patient-Centered Care/*trends
MH  - *Physician's Role
MH  - Physician-Patient Relations/*ethics
EDAT- 2012/09/01 06:00
MHDA- 2013/02/01 06:00
CRDT- 2012/09/01 06:00
PHST- 2012/09/01 06:00 [entrez]
PHST- 2012/09/01 06:00 [pubmed]
PHST- 2013/02/01 06:00 [medline]
AID - 10.1007/s00103-012-1540-1 [doi]
PST - ppublish
SO  - Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2012
      Sep;55(9):1161-7. doi: 10.1007/s00103-012-1540-1.


PMID- 22936483
OWN - NLM
STAT- MEDLINE
DCOM- 20130131
LR  - 20160707
IS  - 1437-1588 (Electronic)
IS  - 1436-9990 (Linking)
VI  - 55
IP  - 9
DP  - 2012 Sep
TI  - [The physician's role in various clinical contexts. The physician's role in
      palliative care].
PG  - 1154-60
LID - 10.1007/s00103-012-1531-2 [doi]
AB  - The palliative care physician accompanies patients and their families in times of
      great disstress and potentially difficult medico-ethical decision making. The
      main objective of palliative care is the alleviation of pain and distressing
      symptoms in patients with progressive, incurable illness. By addressing physical 
      problems and psychosocial as well as spiritual needs, palliative care aims at
      improving the quality of life of patients in order to help them to spend their
      remaining lifetime with as much autonomy as possible and in dignity. The concept 
      of accompaniment in palliative care involves a multiprofessional team. Important 
      factors in this approach are time, trust, professional, ethical, communicative,
      social, and emotional competencies and the attitude of physicians and other
      professionals. The physician is given responsibility by the patient. In accepting
      the role as a respondent to another individual's request for help, the physician 
      can avoid the pitfalls of the obsolete paternalistic relationship model, or of
      one that is either merely autonomy based or of a provider-customer nature.
FAU - Nauck, F
AU  - Nauck F
AD  - Abteilung Palliativmedizin, Zentrum Anaesthesiologie, Rettungs- und
      Intensivmedizin, Georg-August-Universitat Gottingen, Robert-Koch-Str. 40, 37075, 
      Gottingen, Deutschland. Friedemann.Nauck@med.uni-goettingen.de
FAU - Jaspers, B
AU  - Jaspers B
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Die Arztrolle in unterschiedlichen klinischen Kontexten. Der Arzt als Begleiter
      in der Palliativmedizin.
PL  - Germany
TA  - Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
JT  - Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
JID - 101181368
SB  - IM
MH  - Germany
MH  - Humans
MH  - Palliative Care/*ethics
MH  - *Patient Participation
MH  - *Physician's Role
MH  - Physician-Patient Relations/*ethics
MH  - Professional-Family Relations/*ethics
EDAT- 2012/09/01 06:00
MHDA- 2013/02/01 06:00
CRDT- 2012/09/01 06:00
PHST- 2012/09/01 06:00 [entrez]
PHST- 2012/09/01 06:00 [pubmed]
PHST- 2013/02/01 06:00 [medline]
AID - 10.1007/s00103-012-1531-2 [doi]
PST - ppublish
SO  - Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2012
      Sep;55(9):1154-60. doi: 10.1007/s00103-012-1531-2.


PMID- 22936482
OWN - NLM
STAT- MEDLINE
DCOM- 20130131
LR  - 20160707
IS  - 1437-1588 (Electronic)
IS  - 1436-9990 (Linking)
VI  - 55
IP  - 9
DP  - 2012 Sep
TI  - [The physician's role in various clinical contexts. Physician counseling on in
      vitro fertilization (IVF) and preimplantation genetic diagnosis (PGD)].
PG  - 1144-53
LID - 10.1007/s00103-012-1530-3 [doi]
AB  - The role of the physician in the context of in vitro fertilization and
      preimplantation genetic diagnosis has certain distinct characteristics.
      Involuntary childlessness by definition of the WHO is a disease with good
      treatment options. As it is not considered a medical emergency, the focus lies
      more on intensive information giving, education, and counseling. Because the
      diagnosis and treatment can be a medical and psychological strain for the couple,
      counseling should address both medical and psychological aspects. The physician
      needs to have detailed medical knowledge as well as good communication skills to 
      be able to meet the specific needs of the couple. Moreover, the physician should 
      point out the realistic success rates of treatment and should refer to
      alternatives, such as remaining childless, adoption, and sperm or egg donation.
      The concurrent inclusion of biological, psychological, social, and ethical
      aspects in terms of psychosomatic basic care (Psychosomatische Grundversorgung)
      seems to be useful. There is potential for conflicts, for example, due to the
      economic interests of the physician. On the other hand, the treatment can be a
      financial burden for the couple. Of importance are the physician's and the
      patient's moral concepts, especially concerning some aspects of therapy (sperm
      and egg donation, surrogacy). The expected welfare of the intended child should
      also be respected (e.g., higher risk of preterm birth in multiple pregnancies).
      Further possible conflicts in reproductive medicine arise because of the crossing
      of moral boundaries (oocyte donation for postmenopausal women, surrogacy, cloning
      of human beings). The framework of counseling is based on the guidelines of the
      German Medical Association (Bundesarztekammer) for assisted reproduction (2006). 
      Preimplantation genetic diagnosis has special requirements from a medical and
      psychosocial point of view.
FAU - Kentenich, H
AU  - Kentenich H
AD  - Fertility Center Berlin, Spandauer Damm 130, 14050, Berlin, Deutschland.
      kentenich@fertilitycenterberlin.de
FAU - Tandler-Schneider, A
AU  - Tandler-Schneider A
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Die Arztrolle in unterschiedlichen klinischen Kontexten. Arztliche Beratung bei
      In-vitro-Fertilisation (IVF) und Praimplantationsdiagnostik (PID).
PL  - Germany
TA  - Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
JT  - Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
JID - 101181368
SB  - IM
MH  - Female
MH  - Fertilization in Vitro/*ethics
MH  - Genetic Counseling/*ethics
MH  - Germany
MH  - Humans
MH  - *Physician's Role
MH  - Physician-Patient Relations/*ethics
MH  - Preimplantation Diagnosis/*ethics
EDAT- 2012/09/01 06:00
MHDA- 2013/02/01 06:00
CRDT- 2012/09/01 06:00
PHST- 2012/09/01 06:00 [entrez]
PHST- 2012/09/01 06:00 [pubmed]
PHST- 2013/02/01 06:00 [medline]
AID - 10.1007/s00103-012-1530-3 [doi]
PST - ppublish
SO  - Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2012
      Sep;55(9):1144-53. doi: 10.1007/s00103-012-1530-3.


PMID- 22936478
OWN - NLM
STAT- MEDLINE
DCOM- 20130131
LR  - 20160707
IS  - 1437-1588 (Electronic)
IS  - 1436-9990 (Linking)
VI  - 55
IP  - 9
DP  - 2012 Sep
TI  - [Placebo and the relationship between doctors and patients. Overview].
PG  - 1113-7
LID - 10.1007/s00103-012-1526-z [doi]
AB  - In medicine, placebos are used both in scientific studies and for practical
      therapeutic purposes. In evidence-based medicine, the efficacy of treatment may
      be determined as the difference between the effects of the verum (the active
      study drug) and the placebo, the latter being a substance lacking specific action
      on the disease under consideration. However, the improvements in patients'
      conditions under placebo treatment may be substantial and comparable to those
      with verum. Genuine placebos predominate in clinical studies, while
      pseudoplacebos prevail in practical therapy. The term pseudoplacebo can also be
      applied to many procedures in complementary medicine, including homeopathic
      medicine (Buchel et al., Placebo in der Medizin, 2011). The comprehensive
      definition of placebo, as used in a report by the German Medical Association
      (Buchel et al., Placebo in der Medizin, 2011), states that a placebo effect may
      occur even when treating with verum. The placebo effect is modulated by the
      context of the treatment, by the expectations of the patients and the doctors,
      and by the success of the relationship between doctors and patients. A number of 
      unspecific effects, e.g., spontaneous alleviation, statistical effects, variance 
      with time, methodological errors, in addition to the placebo effect make up the
      total response that is called"placebo reaction." A complete list of the
      effectiveness of placebo for all important diseases is still lacking. Further, it
      is not possible to predict which patients will respond to placebo. Which
      characteristics of doctors are important (competence, empathy, communicative
      ability and partnership, trust) in order to achieve a placebo effect,
      particularly in addition to the verum effect measures of evidence-based medicine?
      Are there doctors who are better in this than others? Could the nocebo effect
      weaken the efficacy of treatment in evidence-based medicine? Since a placebo
      effect may occur in almost any standard therapy, information about placebos
      should be provided during medical education and continuing medical education
      (CME). The use of placebo in clinical studies is ethically justified and lawful
      in consenting patients if there is no other effective treatment available with
      which the test substance could be compared. For daily practical therapeutic
      purposes, placebos may be ethically acceptable and lawful if there is no
      effective therapy available, if the complaints are minor, if the patient
      expressly wishes treatment, and if there is a reasonable likelihood of success.
      However, an explanation of the expected benefits and risks must be provided to
      the patients. At present, there are two explanatory theories for the mechanism of
      action of placebo, namely, the associative and the mentalistic explanation
      (Buchel et al., Placebo in der Medizin, 2011). Interestingly, effects of placebo 
      and of verum can be localized in the brain by physiological and anatomical
      techniques. With many open questions remaining, research on placebo is currently 
      very active. These aspect and neurobiological findings in particular may
      facilitate for "scientifically" educated doctors to accept that ineffective
      materials, i.e., placebos, are in fact effective.
FAU - Scriba, P C
AU  - Scriba PC
AD  - Medizinische Klinik Innenstadt, Ludwig-Maximilians-Universitat, Ziemssenstr. 1,
      80336, Munchen, Deutschland. peter.scriba@med.uni-muenchen.de
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Placeboaspekte der Arzt-Patienten-Beziehung. Ubersicht.
PL  - Germany
TA  - Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
JT  - Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
JID - 101181368
SB  - IM
MH  - Clinical Trials as Topic/*ethics
MH  - Germany
MH  - Informed Consent/*ethics
MH  - Patient Participation/*trends
MH  - Patient-Centered Care/*ethics
MH  - *Physician's Role
MH  - Physician-Patient Relations/*ethics
MH  - *Placebo Effect
EDAT- 2012/09/01 06:00
MHDA- 2013/02/01 06:00
CRDT- 2012/09/01 06:00
PHST- 2012/09/01 06:00 [entrez]
PHST- 2012/09/01 06:00 [pubmed]
PHST- 2013/02/01 06:00 [medline]
AID - 10.1007/s00103-012-1526-z [doi]
PST - ppublish
SO  - Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2012
      Sep;55(9):1113-7. doi: 10.1007/s00103-012-1526-z.


PMID- 22936474
OWN - NLM
STAT- MEDLINE
DCOM- 20130131
LR  - 20160707
IS  - 1437-1588 (Electronic)
IS  - 1436-9990 (Linking)
VI  - 55
IP  - 9
DP  - 2012 Sep
TI  - [The doctor-patient relationship against the backdrop of patient-centered
      medicine. The conclusions of dialogical ethics].
PG  - 1085-92
LID - 10.1007/s00103-012-1535-y [doi]
AB  - "Health" and "illness" are multilayered terms. The understanding of human health 
      depends, apart from scientific aspects, on people's individual perceptions as
      well as on aspects of culture and world view. The ideal of patient-centered
      medicine requires that a physician does not merely have to establish an
      objectifiable diagnosis. Rather, a physician should also respect the patients'
      right to self-determination, their personal values, and their subjective view of 
      health and illness. The philosophy of dialogue, which developed in the twentieth 
      century, offers a conceptual background for this ideal. On an empirical basis,
      the successful communication between doctor and patient can be interpreted as a
      useful placebo phenomenon. Alternative medicine puts great emphasis on the
      doctor's attentive care. This also explains why the alternative branch of
      medicine has appealed to many patients. Therefore, science-oriented medicine
      should review methods in which the doctor's empathy and dialogue ability are
      crucial to treatment success. It is part of the physician's responsibility to
      appreciate the personal perspectives of patients, to respect them and, if
      necessary, to engage with them critically.
FAU - Kress, H
AU  - Kress H
AD  - Evangelisch-Theologische Fakultat, Abteilung fur Sozialethik, Universitat Bonn,
      Am Hof 1, 53113, Bonn, Deutschland. hkress@uni-bonn.de
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Das Arzt-Patient-Verhaltnis im Sinn patientenzentrierter Medizin. Ethische
      Grundlagen - heutige Schlussfolgerungen.
PL  - Germany
TA  - Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
JT  - Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
JID - 101181368
SB  - IM
MH  - Complementary Therapies/*ethics/*trends
MH  - Germany
MH  - Patient Participation/*trends
MH  - Patient-Centered Care/*ethics/*trends
MH  - *Physician's Role
MH  - Physician-Patient Relations/*ethics
EDAT- 2012/09/01 06:00
MHDA- 2013/02/01 06:00
CRDT- 2012/09/01 06:00
PHST- 2012/09/01 06:00 [entrez]
PHST- 2012/09/01 06:00 [pubmed]
PHST- 2013/02/01 06:00 [medline]
AID - 10.1007/s00103-012-1535-y [doi]
PST - ppublish
SO  - Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2012
      Sep;55(9):1085-92. doi: 10.1007/s00103-012-1535-y.


PMID- 22936306
OWN - NLM
STAT- MEDLINE
DCOM- 20130607
LR  - 20191210
IS  - 1097-4679 (Electronic)
IS  - 0021-9762 (Linking)
VI  - 69
IP  - 1
DP  - 2013 Jan
TI  - Mind-body CAM interventions: current status and considerations for integration
      into clinical health psychology.
PG  - 45-63
LID - 10.1002/jclp.21910 [doi]
AB  - OBJECTIVE: Complementary and alternative medicine (CAM) is increasingly used for 
      treating myriad health conditions and for maintaining general health. The present
      article provides an overview of current CAM use with a specific focus on
      mind-body CAM and its efficacy in treating health conditions. METHOD:
      Characteristics of CAM users are presented, and then evidence regarding the
      efficacy of mind-body treatments (biofeedback, meditation, guided imagery,
      progressive muscle relaxation, deep breathing, hypnosis, yoga, tai chi, and qi
      gong) is reviewed. RESULTS: Demographics associated with CAM use are fairly
      well-established, but less is known about their psychological characteristics.
      Although the efficacy of mind-body CAM modalities for health conditions is
      receiving a great deal of research attention, studies have thus far produced a
      weak base of evidence. Methodological limitations of current research are
      reviewed. Suggestions are made for future research that will provide more
      conclusive knowledge regarding efficacy and, ultimately, effectiveness of
      mind-body CAM. Considerations for clinical applications, including training and
      competence, ethics, treatment tailoring, prevention efforts, and diversity,
      conclude the article. CONCLUSIONS: Integration of CAM modalities into clinical
      health psychology can be useful for researchers taking a broader perspective on
      stress and coping processes, illness behaviors, and culture; for practitioners
      seeking to incorporate CAM perspectives into their work; and for policy makers in
      directing healthcare resources wisely.
CI  - (c) 2012 Wiley Periodicals, Inc.
FAU - Park, Crystal
AU  - Park C
AD  - University of Connecticut, CT, USA. park@uconn.edu
LA  - eng
PT  - Journal Article
DEP - 20120830
PL  - United States
TA  - J Clin Psychol
JT  - Journal of clinical psychology
JID - 0217132
SB  - IM
MH  - Female
MH  - Humans
MH  - *Integrative Medicine
MH  - Male
MH  - Mind-Body Therapies/*methods
MH  - Motivation
MH  - Outcome Assessment, Health Care
MH  - *Psychology, Clinical
MH  - Research
EDAT- 2012/09/01 06:00
MHDA- 2013/06/08 06:00
CRDT- 2012/09/01 06:00
PHST- 2012/09/01 06:00 [entrez]
PHST- 2012/09/01 06:00 [pubmed]
PHST- 2013/06/08 06:00 [medline]
AID - 10.1002/jclp.21910 [doi]
PST - ppublish
SO  - J Clin Psychol. 2013 Jan;69(1):45-63. doi: 10.1002/jclp.21910. Epub 2012 Aug 30.


PMID- 22936291
OWN - NLM
STAT- MEDLINE
DCOM- 20130813
LR  - 20211021
IS  - 1525-1497 (Electronic)
IS  - 0884-8734 (Linking)
VI  - 28
IP  - 2
DP  - 2013 Feb
TI  - Experiencing the culture of academic medicine: gender matters, a national study.
PG  - 201-7
LID - 10.1007/s11606-012-2207-1 [doi]
AB  - BACKGROUND: Energized and productive faculty are critical to academic medicine,
      yet studies indicate a lack of advancement and senior roles for women. OBJECTIVE:
      Using measures of key aspects of the culture of academic medicine, this study
      sought to identify similarity and dissimilarity between perceptions of the
      culture by male and female faculty. DESIGN: The C - Change Faculty Survey was
      used to collect data on perceptions of organizational culture. PARTICIPANTS: A
      stratified random sample of 4,578 full-time faculty at 26 nationally
      representative US medical colleges (response rate 52 %). 1,271 (53 %) of
      respondents were female. MAIN MEASURES: Factor analysis assisted in the creation 
      of scales assessing dimensions of the culture, which served as the key outcomes. 
      Regression analysis identified gender differences while controlling for other
      demographic characteristics. KEY RESULTS: Compared with men, female faculty
      reported a lower sense of belonging and relationships within the workplace (T =
      -3.30, p < 0.01). Self-efficacy for career advancement was lower in women (T =
      -4.73, p < 0.001). Women perceived lower gender equity (T = -19.82, p < 0.001),
      and were less likely to believe their institutions were making changes to address
      diversity goals (T = -9.70, p < 0.001). Women were less likely than men to
      perceive their institution as family-friendly (T = -4.06, p < 0.001), and women
      reported less congruence between their own values and those of their institutions
      (T = -2.06, p < 0.05). Women and men did not differ significantly on levels of
      engagement, leadership aspirations, feelings of ethical/moral distress,
      perception of institutional commitment to faculty advancement, or perception of
      institutional change efforts to improve support for faculty. CONCLUSIONS: Faculty
      men and women are equally engaged in their work and share similar leadership
      aspirations. However, medical schools have failed to create and sustain an
      environment where women feel fully accepted and supported to succeed; how can we 
      ensure that medical schools are fully using the talent pool of a third of its
      faculty?
FAU - Pololi, Linda H
AU  - Pololi LH
AD  - Women's Studies Research Center, National Initiative on Gender, Culture and
      Leadership in Medicine, C - Change, Brandeis University, Waltham, MA, USA.
      lpololi@brandeis.edu
FAU - Civian, Janet T
AU  - Civian JT
FAU - Brennan, Robert T
AU  - Brennan RT
FAU - Dottolo, Andrea L
AU  - Dottolo AL
FAU - Krupat, Edward
AU  - Krupat E
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20120831
PL  - United States
TA  - J Gen Intern Med
JT  - Journal of general internal medicine
JID - 8605834
SB  - IM
MH  - Academic Medical Centers/*organization & administration
MH  - Adult
MH  - Attitude of Health Personnel
MH  - Career Mobility
MH  - Faculty, Medical/organization & administration
MH  - Female
MH  - Humans
MH  - Job Satisfaction
MH  - Leadership
MH  - Male
MH  - Middle Aged
MH  - *Organizational Culture
MH  - Physicians, Women/*psychology
MH  - Psychometrics
MH  - Schools, Medical/*organization & administration
MH  - Self Efficacy
MH  - Sexism/psychology/*statistics & numerical data
MH  - United States
PMC - PMC3614142
EDAT- 2012/09/01 06:00
MHDA- 2013/08/14 06:00
CRDT- 2012/09/01 06:00
PHST- 2012/04/26 00:00 [received]
PHST- 2012/07/23 00:00 [accepted]
PHST- 2012/07/18 00:00 [revised]
PHST- 2012/09/01 06:00 [entrez]
PHST- 2012/09/01 06:00 [pubmed]
PHST- 2013/08/14 06:00 [medline]
AID - 10.1007/s11606-012-2207-1 [doi]
PST - ppublish
SO  - J Gen Intern Med. 2013 Feb;28(2):201-7. doi: 10.1007/s11606-012-2207-1. Epub 2012
      Aug 31.


PMID- 22936093
OWN - NLM
STAT- MEDLINE
DCOM- 20130610
LR  - 20191027
IS  - 1678-2674 (Electronic)
IS  - 0102-8650 (Linking)
VI  - 27
IP  - 9
DP  - 2012 Sep
TI  - Progress in animal experimentation ethics: a case study from a Brazilian medical 
      school and from the international medical literature.
PG  - 659-63
LID - S0102-86502012000900012 [pii]
AB  - PURPOSE: This study describes in Brazil and in the global biomedical community
      the time course of the development of animal research welfare guidelines.
      METHODS: The database of the Ethics Committee of the Faculty of Medicine of
      Ribeirao Preto (EC/FMRP-USP), Brazil, was surveyed since its inception in 2002 as
      the regulations became more stringent to provide better protection of animal
      research welfare at this institution. Medline database was evaluated to identify 
      the number of publications in the period between 1968 and 2008 that used research
      animals and were in compliance with established ethics guidelines. RESULTS: The
      EC/FMRP-USP evaluated 979 projects up until 2009. Most of the applications came
      from Department of Physiology and the most frequently requested species was the
      rat. In 2004, national research funding agencies started to request prior
      approval from institutional review ethics committees prior to application review 
      and this requirement became federal law in Brazil in 2008. The analysis of
      international publications revealed a relative reduction in studies involving
      research animals (18% in 1968 to 7.5% in 2008). CONCLUSIONS: The present work
      showed that in the last four decades major changes occurred in the guidelines
      dictating use of research animals occurred and they are being adopted by
      developing countries. Moreover, animal welfare concern in the scientific
      community preceded the introduction of journal guidelines for this purpose.
      Furthermore, in Brazil it was anticipated that laws were needed to protect animal
      research welfare from being not upheld.
FAU - Ramalli, Edvaldo Luiz Jr
AU  - Ramalli EL Jr
AD  - Faculty of Medicine of Ribeirao Preto, USP, Sao Paulo, Brazil.
FAU - Ho, Wanli
AU  - Ho W
FAU - Alves, Monica
AU  - Alves M
FAU - Rocha, Eduardo Melani
AU  - Rocha EM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Brazil
TA  - Acta Cir Bras
JT  - Acta cirurgica brasileira
JID - 9103983
SB  - IM
MH  - Animal Experimentation/*ethics/legislation & jurisprudence
MH  - Animal Welfare/*ethics/legislation & jurisprudence
MH  - Animals
MH  - Biomedical Research/*ethics/legislation & jurisprudence
MH  - Ethics, Research
EDAT- 2012/09/01 06:00
MHDA- 2013/06/12 06:00
CRDT- 2012/09/01 06:00
PHST- 2012/04/30 00:00 [received]
PHST- 2012/07/27 00:00 [accepted]
PHST- 2012/09/01 06:00 [entrez]
PHST- 2012/09/01 06:00 [pubmed]
PHST- 2013/06/12 06:00 [medline]
AID - S0102-86502012000900012 [pii]
AID - 10.1590/s0102-86502012000900012 [doi]
PST - ppublish
SO  - Acta Cir Bras. 2012 Sep;27(9):659-63. doi: 10.1590/s0102-86502012000900012.


PMID- 22935445
OWN - NLM
STAT- MEDLINE
DCOM- 20130516
LR  - 20220316
IS  - 1097-685X (Electronic)
IS  - 0022-5223 (Linking)
VI  - 145
IP  - 3
DP  - 2013 Mar
TI  - The influence of preoperative serum anticholinergic activity and other risk
      factors for the development of postoperative cognitive dysfunction after cardiac 
      surgery.
PG  - 805-11
LID - 10.1016/j.jtcvs.2012.07.043 [doi]
LID - S0022-5223(12)00887-2 [pii]
AB  - OBJECTIVE: Patients undergoing cardiac surgery are at risk for postoperative
      cognitive dysfunction (POCD). Evaluating preoperative risk factors represents 1
      possible way to minimize the postoperative risk of cognitive dysfunction. We
      investigated marked deterioration in cholinergic neurotransmission as 1 such
      potential risk factor for transient and long-lasting POCD. Serum anticholinergic 
      activity (SAA) has already been described as a risk factor for developing
      delirium in an elderly study population. However, the role of SAA for
      long-lasting POCD is unknown. METHODS: Following local ethics board approval and 
      written informed consent, we recruited a cohort of patients aged >/= 55 years
      undergoing cardiac surgery. Before surgery, levels of SAA were measured and a
      battery of neuropsychologic tests (NPTs) was applied. S100 calcium binding
      protein ss concentration was measured intraoperatively. Pre-, intra-, and
      postoperative patient-specific characteristics were recorded. The NPTs were
      repeated 3 months after hospital discharge to evaluate 3-month POCD. A group of
      nonsurgical patients (n = 34) was recruited as control subjects to adjust NPT
      scores, using reliable methods for the change index. Logistic multivariate
      regression was used to evaluate independent predictors of POCD. RESULTS: One
      hundred fifty-four patients were screened before surgery, and 117 completed the
      second NPT. POCD was identified in 25.6% of patients. In contrast to
      intraoperatively increased S100 calcium binding protein ss, preoperative SAA was 
      not associated with POCD following adjustment for covariates. CONCLUSIONS:
      Preoperatively increased SAA did not predict POCD 3 months after cardiac surgery.
CI  - Copyright (c) 2013 The American Association for Thoracic Surgery. Published by
      Mosby, Inc. All rights reserved.
FAU - Plaschke, Konstanze
AU  - Plaschke K
AD  - Department of Anesthesiology, University of Heidelberg, Heidelberg, Germany.
      konstanze.plaschke@med.uni-heidelberg.de
FAU - Hauth, Steffen
AU  - Hauth S
FAU - Jansen, Claudia
AU  - Jansen C
FAU - Bruckner, Thomas
AU  - Bruckner T
FAU - Schramm, Christoph
AU  - Schramm C
FAU - Karck, Matthias
AU  - Karck M
FAU - Kopitz, Jurgen
AU  - Kopitz J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120827
PL  - United States
TA  - J Thorac Cardiovasc Surg
JT  - The Journal of thoracic and cardiovascular surgery
JID - 0376343
RN  - 0 (Biomarkers)
RN  - 0 (Cholinergic Antagonists)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (S100 Calcium Binding Protein beta Subunit)
RN  - 0 (S100 Proteins)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - *Cardiac Surgical Procedures
MH  - Chi-Square Distribution
MH  - Cholinergic Antagonists/*blood
MH  - Cognition Disorders/*blood/epidemiology/*prevention & control
MH  - Female
MH  - Germany/epidemiology
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Nerve Growth Factors/blood
MH  - Neuropsychological Tests
MH  - Risk Factors
MH  - S100 Calcium Binding Protein beta Subunit
MH  - S100 Proteins/blood
MH  - Statistics, Nonparametric
EDAT- 2012/09/01 06:00
MHDA- 2013/05/17 06:00
CRDT- 2012/09/01 06:00
PHST- 2011/10/25 00:00 [received]
PHST- 2012/06/14 00:00 [revised]
PHST- 2012/07/25 00:00 [accepted]
PHST- 2012/09/01 06:00 [entrez]
PHST- 2012/09/01 06:00 [pubmed]
PHST- 2013/05/17 06:00 [medline]
AID - S0022-5223(12)00887-2 [pii]
AID - 10.1016/j.jtcvs.2012.07.043 [doi]
PST - ppublish
SO  - J Thorac Cardiovasc Surg. 2013 Mar;145(3):805-11. doi:
      10.1016/j.jtcvs.2012.07.043. Epub 2012 Aug 27.


PMID- 22935133
OWN - NLM
STAT- MEDLINE
DCOM- 20130516
LR  - 20220410
IS  - 1471-2431 (Electronic)
IS  - 1471-2431 (Linking)
VI  - 12
DP  - 2012 Aug 30
TI  - PELICAN: A quality of life instrument for childhood asthma: study protocol of two
      randomized controlled trials in primary and specialized care in the Netherlands.
PG  - 137
LID - 10.1186/1471-2431-12-137 [doi]
AB  - BACKGROUND: Asthma is one of the major chronic health problems in children in the
      Netherlands. The Pelican is a paediatric asthma-related quality of life
      instrument for children with asthma from 6-11 years old, which is suitable for
      clinical practice in primary and specialized care. Based on this instrument, we
      developed a self-management treatment to improve asthma-related quality of life. 
      The Pelican intervention will be investigated in different health care settings. 
      Results of intervention studies are often extrapolated to other health care
      settings than originally investigated. Because of differences in organization,
      disease severity, patient characteristics and care provision between health care 
      settings, extrapolating research results could lead to unnecessary health costs
      without the desired health care achievements. Therefore, interventions have to be
      investigated in different health care settings when possible. This study is an
      example of an intervention study in different health care settings. In this
      article, we will present the study protocol of the Pelican study in primary and
      specialized care. METHOD/DESIGN: This study consists of two randomized controlled
      trials to assess the effectiveness of the Pelican intervention in primary and
      specialized care. The trial in primary care is a multilevel design with 170
      children with asthma in 16 general practices. All children in one general
      practices are allocated to the same treatment group. The trial in specialized
      care is a multicentre trial with 100 children with asthma. Children in one
      outpatient clinic are randomly allocated to the intervention or usual care group.
      In both trials, children will visit the care provider four times during a
      follow-up of nine months. This study is registered and ethically approved.
      DISCUSSION: This article describes the study protocol of the Pelican study in
      different health care settings. If the Pelican intervention proves to be
      effective and efficient, implementation in primary and specialized care for
      paediatric asthma in the Netherlands will be recommended. TRIAL REGISTRATION:
      This study is registered by clinicaltrial.gov (NCT01109745).
FAU - van Bragt, Stephanie
AU  - van Bragt S
AD  - Department of Primary and Community Care, Radboud University Nijmegen Medical
      Centre, The Netherlands. s.vanbragt@elg.umcn.nl
FAU - van den Bemt, Lisette
AU  - van den Bemt L
FAU - Thoonen, Bart
AU  - Thoonen B
FAU - van Weel, Chris
AU  - van Weel C
FAU - Merkus, Peter
AU  - Merkus P
FAU - Schermer, Tjard
AU  - Schermer T
LA  - eng
SI  - ClinicalTrials.gov/NCT01109745
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20120830
PL  - England
TA  - BMC Pediatr
JT  - BMC pediatrics
JID - 100967804
SB  - IM
MH  - Asthma/economics/*therapy
MH  - Child
MH  - Clinical Protocols
MH  - Cost-Benefit Analysis
MH  - Follow-Up Studies
MH  - *Health Status Indicators
MH  - Humans
MH  - Netherlands
MH  - Outcome and Process Assessment, Health Care
MH  - Patient Selection
MH  - *Primary Health Care/economics
MH  - *Quality of Life
MH  - Sample Size
MH  - *Secondary Care/economics
MH  - Self Care/economics/*methods
MH  - Surveys and Questionnaires
PMC - PMC3512535
EDAT- 2012/09/01 06:00
MHDA- 2013/05/17 06:00
CRDT- 2012/09/01 06:00
PHST- 2012/06/25 00:00 [received]
PHST- 2012/08/15 00:00 [accepted]
PHST- 2012/09/01 06:00 [entrez]
PHST- 2012/09/01 06:00 [pubmed]
PHST- 2013/05/17 06:00 [medline]
AID - 1471-2431-12-137 [pii]
AID - 10.1186/1471-2431-12-137 [doi]
PST - epublish
SO  - BMC Pediatr. 2012 Aug 30;12:137. doi: 10.1186/1471-2431-12-137.


PMID- 22935121
OWN - NLM
STAT- MEDLINE
DCOM- 20121004
LR  - 20120831
IS  - 0156-5788 (Print)
IS  - 0156-5788 (Linking)
VI  - 36
IP  - 3
DP  - 2012 Aug
TI  - International medical graduates' reflections on facilitators and barriers to
      undertaking the Australian medical council examination.
PG  - 296-300
LID - 10.1071/AH11082 [doi]
AB  - OBJECTIVE: In Australia, 25% of international medical graduates (IMGs) make up
      the medical workforce. Concern is expressed in the literature about the lack of
      awareness and knowledge of issues that impinge on IMGs' education. Although there
      is literature alluding to difficulties IMGs face with undertaking the Australian 
      Medical Council (AMC) examination, there is little research detailing this
      experience. We therefore explored IMGs' reflections on facilitators and barriers 
      in undertaking the AMC examination. METHODS: After ethics approval, in-depth
      telephone interviews were conducted with 30 IMGs selected from a hospital in
      Queensland. Data were coded and analysed using thematic analysis principles.
      Results. Two facilitating themes were identified: ability to sit for the first
      part of the examination in country of origin; and having access to resources such
      as bridging courses and study groups. Three themes represented barriers: not
      understanding procedural steps; financial issues; and lack of information on
      examination content and standards. CONCLUSION: The themes provide new insights
      and add depth to existing literature that can be used to improve procedural
      processes and education for IMGs towards successful outcomes in the AMC
      examination.
FAU - McGrath, Pam
AU  - McGrath P
AD  - Population and Social Health Research Program, Centre of National Research on
      Disability and Rehabilitation Medicine, Griffith Health Institute, Griffith
      University, Brisbane, QLD 4131, Australia. p.mcgrath@griffith.edu.au
FAU - Henderson, Saras
AU  - Henderson S
FAU - Holewa, Hamish A
AU  - Holewa HA
FAU - Henderson, David
AU  - Henderson D
FAU - Tamargo, John
AU  - Tamargo J
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Aust Health Rev
JT  - Australian health review : a publication of the Australian Hospital Association
JID - 8214381
MH  - Australia
MH  - Clinical Competence
MH  - *Educational Measurement
MH  - Foreign Medical Graduates/*psychology
MH  - Humans
MH  - Interviews as Topic
EDAT- 2012/09/01 06:00
MHDA- 2012/10/05 06:00
CRDT- 2012/09/01 06:00
PHST- 2011/08/31 00:00 [received]
PHST- 2012/02/12 00:00 [accepted]
PHST- 2012/09/01 06:00 [entrez]
PHST- 2012/09/01 06:00 [pubmed]
PHST- 2012/10/05 06:00 [medline]
AID - AH11082 [pii]
AID - 10.1071/AH11082 [doi]
PST - ppublish
SO  - Aust Health Rev. 2012 Aug;36(3):296-300. doi: 10.1071/AH11082.


PMID- 22934368
OWN - NLM
STAT- MEDLINE
DCOM- 20121101
LR  - 20190513
IS  - 0026-4075 (Print)
IS  - 0026-4075 (Linking)
VI  - 177
IP  - 8
DP  - 2012 Aug
TI  - Use of animals by NATO countries in military medical training exercises: an
      international survey.
PG  - 907-10
AB  - Among the 28 member nations of the North Atlantic Treaty Organization (NATO), a
      variety of training methodologies--including simulators, moulage scenarios,
      didactics and live animal laboratories-are used to prepare military medical
      personnel to treat injured civilians and soldiers. For ethical, educational,
      practical, and economic reasons, the necessity of animal use for this purpose has
      come into question. This article reports the results of a survey examining the
      prevalence of animal use in military medical training exercises among all NATO
      nations, finding that more than three-quarters of these countries do not use
      animals.
FAU - Gala, Shalin G
AU  - Gala SG
AD  - People for the Ethical Treatment of Animals, Laboratory Investigations Division, 
      501 Front Street, Norfolk, VA 23510, USA.
FAU - Goodman, Justin R
AU  - Goodman JR
FAU - Murphy, Michael P
AU  - Murphy MP
FAU - Balsam, Marion J
AU  - Balsam MJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - Mil Med
JT  - Military medicine
JID - 2984771R
SB  - IM
CIN - Mil Med. 2012 Dec;177(12):viii. PMID: 23397684
MH  - Animal Experimentation/*statistics & numerical data
MH  - Animals
MH  - Humans
MH  - *Internationality
MH  - Military Medicine/*education
MH  - Surveys and Questionnaires
EDAT- 2012/09/01 06:00
MHDA- 2012/11/02 06:00
CRDT- 2012/09/01 06:00
PHST- 2012/09/01 06:00 [entrez]
PHST- 2012/09/01 06:00 [pubmed]
PHST- 2012/11/02 06:00 [medline]
AID - 10.7205/milmed-d-12-00056 [doi]
PST - ppublish
SO  - Mil Med. 2012 Aug;177(8):907-10. doi: 10.7205/milmed-d-12-00056.


PMID- 31214402
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 2146-4618 (Print)
IS  - 2146-4626 (Linking)
VI  - 1
IP  - 3
DP  - 2012 Sep
TI  - Umbilical venous blood gas analysis for neonatal assessment.
PG  - 161-164
LID - 10.3233/PIC-2012-026 [doi]
AB  - Umbilical venous pH is claimed to mirror fetal acid-base status. Importantly, it 
      is easier to perform. The aim of this study is to : 1. Evaluate the umbilical
      venous blood gas (UVBG) profile of normal newborns and to compare UVBG in the
      following situations: presence or absence of asphyxia presence or absence of
      meconium-stained amniotic fluid presence or absence of respiratory distress: and 
      in newborns that did and did not survive and 2. To study the peripheral venous
      blood gas (PVBG) profile of newborns that develop cardio-respiratory
      insufficiency (CRI). Venous blood gas (VBG) was performed in 961 newborns
      consecutively admitted to the neonatal nursery over one year and in 100 controls.
      PVBG was also performed in 370 admissions to the nursery that developed signs of 
      CRI. Demographic, clinical and outcome data were collected. Mean UVBG parameters 
      (pH, pCO2, HCO3, base deficit, pO2 and SO2%) were compared between different
      groups of newborns using t test. This study had ethical approval. Of the 3349
      live births over one year, 961 (28.7%) needed intensive care. Of these, 123
      (12.8%) died. All the mean cord gas parameters differed significantly between who
      died and who survived. Metabolic acidosis and hypoxemia were conspicuous on PVBG 
      among babies with CRI. Except for PO2 all the mean parameters of UVBG differed
      significantly with asphyxia and meconium-stained amniotic fluid. When similar
      comparison was made among newborns that did or that did not develop respiratory
      distress, the difference was significant for all the parameters except SO2%. UVBG
      gives useful information about common neonatal morbidities and appears to be a
      useful tool for neonatal assessment. PVBG gives objective information about
      babies with CRI that may need special interventions.
FAU - Daga, Subhashchandra R
AU  - Daga SR
AD  - Department of Pediatrics, Cama and Albless Hospital, Mumbai, India.
FAU - Kulkarni, Satish K
AU  - Kulkarni SK
AD  - Department of Pediatrics, Cama and Albless Hospital, Mumbai, India.
FAU - Sharma, Arti S
AU  - Sharma AS
AD  - Department of Pediatrics, Cama and Albless Hospital, Mumbai, India.
FAU - Verma, Bela V
AU  - Verma BV
AD  - Department of Pediatrics, Cama and Albless Hospital, Mumbai, India.
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - J Pediatr Intensive Care
JT  - Journal of pediatric intensive care
JID - 101592756
PMC - PMC6530690
OTO - NOTNLM
OT  - Neonatal assessment
OT  - birth asphyxia
OT  - cord blood gases
OT  - fetal distress
OT  - meconium staining
OT  - perinatal asphyxia
OT  - respiratory distress
EDAT- 2012/09/01 00:00
MHDA- 2012/09/01 00:01
CRDT- 2019/06/20 06:00
PHST- 2019/06/20 06:00 [entrez]
PHST- 2012/09/01 00:00 [pubmed]
PHST- 2012/09/01 00:01 [medline]
AID - 10.3233/PIC-2012-026 [doi]
AID - PIC026 [pii]
PST - ppublish
SO  - J Pediatr Intensive Care. 2012 Sep;1(3):161-164. doi: 10.3233/PIC-2012-026.


PMID- 31051896
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1876-7982 (Electronic)
IS  - 1876-7982 (Linking)
VI  - 43
IP  - 3
DP  - 2012 Sep
TI  - Hoping for the Best While Preparing for the Worst: A Literature Review of the
      Role of Hope in Palliative Cancer Patients.
PG  - 168-174
LID - 10.1016/j.jmir.2011.10.002 [doi]
AB  - Palliative care and hope have both been known to improve the quality of life
      (QoL) of palliative cancer patients. Hope is a complex, multidimensional concept 
      that is influenced by a variety of factors and is considered to be an effective
      coping strategy when dealing with serious illness. Review of the literature
      identifies an abundance of hope-fostering strategies that healthcare
      professionals (HCPs) can use to assist patients to improve their QoL. Ethical
      issues can arise during HCPs' struggles to remain truthful while attempting to
      maintain patients' hopes. Increased communication regarding realistic treatment
      outcomes between the multidisciplinary team and the patient and family is
      essential for maintaining a patient's hope during the terminal stage of disease. 
      Effective communication with patients demonstrates respect for autonomy and
      allows for informed decision-making regarding end-of-life interests. This results
      in the achievement of final end-of-life goals and will increase QoL, which is
      considered to be the goal of palliative care.
CI  - Copyright (c) 2012. Published by Elsevier Inc.
FAU - Feuz, Carina
AU  - Feuz C
AD  - Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada;
      Department of Radiation Oncology, University of Toronto, Toronto, Ontario,
      Canada.
LA  - eng
PT  - Journal Article
DEP - 20120121
PL  - United States
TA  - J Med Imaging Radiat Sci
JT  - Journal of medical imaging and radiation sciences
JID - 101469694
EDAT- 2012/09/01 00:00
MHDA- 2012/09/01 00:01
CRDT- 2019/05/05 06:00
PHST- 2011/06/03 00:00 [received]
PHST- 2011/09/25 00:00 [revised]
PHST- 2011/10/12 00:00 [accepted]
PHST- 2019/05/05 06:00 [entrez]
PHST- 2012/09/01 00:00 [pubmed]
PHST- 2012/09/01 00:01 [medline]
AID - S1939-8654(11)00107-X [pii]
AID - 10.1016/j.jmir.2011.10.002 [doi]
PST - ppublish
SO  - J Med Imaging Radiat Sci. 2012 Sep;43(3):168-174. doi:
      10.1016/j.jmir.2011.10.002. Epub 2012 Jan 21.


PMID- 29776267
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1744-828X (Electronic)
IS  - 1741-0541 (Linking)
VI  - 9
IP  - 7
DP  - 2012 Sep
TI  - Whole genomes, small children, big questions.
PG  - 667-669
LID - 10.2217/pme.12.75 [doi]
FAU - Lunshof, Jeantine E
AU  - Lunshof JE
AD  - Department of Molecular Cell Physiology & Netherlands Institute for Systems
      Biology, VU University Amsterdam, De Boelelaan 1085, 1081 HV Amsterdam, The
      Netherlands and Maastricht University, 6200 MD Maastricht, The Netherlands.
      j.lunshof@vu.nl.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Per Med
JT  - Personalized medicine
JID - 101238549
OTO - NOTNLM
OT  - children
OT  - clinical care
OT  - ethics
OT  - n = 1 studies
OT  - noninvasive prenatal diagnosis
OT  - whole-exome sequencing
OT  - whole-genome sequencing
EDAT- 2012/09/01 00:00
MHDA- 2012/09/01 00:01
CRDT- 2018/05/20 06:00
PHST- 2018/05/20 06:00 [entrez]
PHST- 2012/09/01 00:00 [pubmed]
PHST- 2012/09/01 00:01 [medline]
AID - 10.2217/pme.12.75 [doi]
PST - ppublish
SO  - Per Med. 2012 Sep;9(7):667-669. doi: 10.2217/pme.12.75.


PMID- 27152120
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1754-0763 (Print)
IS  - 1754-0763 (Linking)
VI  - 5
IP  - 2
DP  - 2012 Sep
TI  - Medical Archives and Digital Culture.
PG  - 179-202
AB  - When BioShock was released in 2007, reviewers praised the moral complexities of
      the narrative and the game's dystopian vision of what Ayn Rand dubbed the "virtue
      of selfishness". What critics overlooked was the extent to which the disturbingly
      realistic artwork and musical score relied on found images and sound, including a
      recording of distressed breathing from a physician's website, and digitised First
      World War medical photographs of soldiers with facial injuries. This article
      examines the implications of these acts of appropriation from a range of critical
      perspectives including Susan Sontag's commentary on the representation of
      suffering; recent literature on the ethics of computer games; and an online
      discussion forum in which players of BioShock discuss the moral "grey areas" of
      the game.
FAU - Biernoff, Suzannah
AU  - Biernoff S
LA  - eng
PT  - Journal Article
DEP - 20120910
PL  - England
TA  - Photographies
JT  - Photographies
JID - 101681657
PMC - PMC4851239
EDAT- 2012/09/01 00:00
MHDA- 2012/09/01 00:01
CRDT- 2016/05/07 06:00
PHST- 2016/05/07 06:00 [entrez]
PHST- 2012/09/01 00:00 [pubmed]
PHST- 2012/09/01 00:01 [medline]
AID - 10.1080/17540763.2012.702680 [doi]
PST - ppublish
SO  - Photographies. 2012 Sep;5(2):179-202. doi: 10.1080/17540763.2012.702680. Epub
      2012 Sep 10.


PMID- 27047880
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160406
LR  - 20220317
IS  - 2255-4971 (Print)
IS  - 2255-4971 (Linking)
VI  - 47
IP  - 5
DP  - 2012 Sep-Oct
TI  - IMPORTANCE OF A NATIONAL ARTHROPLASTY REGISTER FOR IDENTIFICATION BY MEDICAL
      EXAMINER.
PG  - 651-5
LID - 10.1016/S2255-4971(15)30018-5 [doi]
AB  - Mass catastrophes are realities that come to pass with lamentable frequency. In
      such situations, one of the fundamental forensic problems is in relation to
      identifying the victims. All the elements that might be capable of contributing
      towards this identification process are essential, and among these are orthopedic
      prostheses, which frequently remain intact. These prostheses consist basically of
      polymers, ceramics or metals. Metal components, which are usually composed of
      titanium, chromium, cobalt or steel alloys, are resistant to violent trauma or
      high temperatures. Human identification is possible if the identity of the
      implant is established and if this can be correlated with the individual in whom 
      it was implanted. The logo on the prosthesis establishes who the manufacturer was
      and the serial number can be compared with the clinical process or with a
      prosthesis register, as has been implemented in several countries. The
      information in the database should include the patient's name, the implant model 
      and its serial number, for consultation only in cases of forensic identification,
      while obviously respecting ethical issues of privacy. This article highlights the
      importance of creating a national prosthesis register.
FAU - Durao, Carlos Henrique
AU  - Durao CH
AD  - Military Physician and Orthopedist at Hospital de Vila Franca de Xira; Medical
      Examiner in the Medical Examiners' Office, Torres Vedras. Postgraduate Degree in 
      Forensic Anthropology from the University of Coimbra, Portugal.
FAU - Pinto, Rui
AU  - Pinto R
AD  - Director of the Orthopedics Service, Hospital de Sao Joao, Porto, Portugal.
FAU - Ribeiro, Costa
AU  - Ribeiro C
AD  - National Coordinator of the Portuguese Arthroplasty Register and Orthopedist at
      the Hospital Center of Tamega e Sousa, Penafiel, Portugal.
FAU - Vieira, Duarte
AU  - Vieira D
AD  - Professor and Chair of the Coimbra School of Medicine and President of the INML, 
      Coimbra, Portugal.
LA  - eng
PT  - Journal Article
DEP - 20151104
PL  - Brazil
TA  - Rev Bras Ortop
JT  - Revista brasileira de ortopedia
JID - 101660959
PMC - PMC4799434
OTO - NOTNLM
OT  - Disasters
OT  - Forensic Anthropology
OT  - Forensic Medicine
OT  - Forensic Pathology
EDAT- 2012/09/01 00:00
MHDA- 2012/09/01 00:01
CRDT- 2016/04/06 06:00
PHST- 2012/01/10 00:00 [received]
PHST- 2012/01/23 00:00 [accepted]
PHST- 2016/04/06 06:00 [entrez]
PHST- 2012/09/01 00:00 [pubmed]
PHST- 2012/09/01 00:01 [medline]
AID - 10.1016/S2255-4971(15)30018-5 [doi]
AID - S2255-4971(15)30018-5 [pii]
PST - epublish
SO  - Rev Bras Ortop. 2015 Nov 4;47(5):651-5. doi: 10.1016/S2255-4971(15)30018-5.
      eCollection 2012 Sep-Oct.


PMID- 26168509
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150715
LR  - 20150714
IS  - 1745-6916 (Print)
IS  - 1745-6916 (Linking)
VI  - 7
IP  - 5
DP  - 2012 Sep
TI  - Likes Attract: The Sociopolitical Groupthink of (Social) Psychologists.
PG  - 512-5
LID - 10.1177/1745691612455206 [doi]
AB  - Inbar and Lammers (2012, this issue) contribute to the growing empirical evidence
      of discrimination against conservative (i.e., right-of-center) people and ideas
      not only in social and personality psychology, but within the academy generally. 
      Because sociopolitical values are often a core component of self-identity that
      significantly impact our interpersonal relationships, sociopolitical
      discrimination is difficult to overcome. There is a tendency to marginalize the
      sociopolitical "other," along with a groupthink that implicitly presupposes that 
      this form of discrimination is acceptable (e.g., because conservatives are
      self-interestedly motivated, conservative ideas are incorrect, or conservatism is
      well represented elsewhere in society and thus need not be in the academy). Yet
      discrimination must be overcome because sociopolitical diversity is vital for
      scholarly inquiry, pedagogy, and for ethical professional practice. Recent
      research suggests that the assumptions underlying psychology's value system of
      promoting racial, ethnic, gender, or sexual orientation diversity-that is, that
      doing so recognizes people's personal identities, ameliorates discrimination, and
      has educational benefits-may be all the more compelling with respect to
      sociopolitical ideas.
CI  - (c) The Author(s) 2012.
FAU - Redding, Richard E
AU  - Redding RE
AD  - School of Law and Schmid College of Science, Chapman University
      redding@chapman.edu.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Perspect Psychol Sci
JT  - Perspectives on psychological science : a journal of the Association for
      Psychological Science
JID - 101274347
OTO - NOTNLM
OT  - discrimination
OT  - diversity
OT  - political ideology
EDAT- 2012/09/01 00:00
MHDA- 2012/09/01 00:01
CRDT- 2015/07/14 06:00
PHST- 2015/07/14 06:00 [entrez]
PHST- 2012/09/01 00:00 [pubmed]
PHST- 2012/09/01 00:01 [medline]
AID - 1745691612455206 [pii]
AID - 10.1177/1745691612455206 [doi]
PST - ppublish
SO  - Perspect Psychol Sci. 2012 Sep;7(5):512-5. doi: 10.1177/1745691612455206.


PMID- 25780648
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150317
LR  - 20201001
IS  - 2093-6966 (Print)
IS  - 2093-6966 (Linking)
VI  - 15
IP  - 3
DP  - 2012 Sep
TI  - Study of Single-dose Toxicity of Aconitum Kusnezoffii Reichb. Pharmacopuncture in
      Rats.
PG  - 48-52
LID - 10.3831/KPI.2012.15.007 [doi]
AB  - OBJECTIVE: This study was performed to analyze the singledose toxicity of
      Aconitum kusnezoffii Reichb. pharmacopuncture (AKRP). METHODS: All experiments
      were conducted at the Korea Testing & Research Institute (KTRI), an institute
      authorized to perform non-clinical studies, under the regulations of Good
      Laboratory Practice (GLP). Twenty (20) Sprague-Dawley rats were chosen for the
      pilot study. The animals were divided into four groups of five animals per group:
      group 1 (G1) being the control group with each animal receiving an injection of
      0.3 ml of saline and groups 2, 3, and 4 (G2, G3, and G4) being the experimental
      groups with each animal receiving an injection of 0.1, 0.2 or 0.3 ml of AKRP,
      respectively. This study was conducted with the approval of the Institutional
      Animal Ethics Committee. RESULTS: No deaths occurred in any of the 4 groups, and 
      the LD50 of AKRP administered via IV was higher than 1.77 ml/kg. Some changes in 
      the weights of the male rates were observed between the control group and the
      experimental groups, but no significant differences were noted in the weights of 
      the female rats. To check for abnormalities in organs and tissues, we stained
      representative sections of each specified organ with Hematoxylin & Eosin for
      light microscopic examination. The results showed no significant differences in
      any of the organs or tissues. CONCLUSIONS: The above findings suggest that
      Aconitum kusnezoffii Reichb. pharmacopuncture is a relatively safe treatment.
      Further studies on the subject should be conducted to yield more concrete
      evidence.
FAU - Kim, JaeKyoun
AU  - Kim J
AD  - Department of Acupuncture & Moxibustion, Wonkwang Gwangju Oriental Medical
      Hospital, Gwangju, Korea ; WUGOH ALS Center of Wonkwang University, Gwangju,
      Korea.
FAU - Kim, Sungha
AU  - Kim S
AD  - Department of Acupuncture & Moxibustion, Wonkwang Gwangju Oriental Medical
      Hospital, Gwangju, Korea ; WUGOH ALS Center of Wonkwang University, Gwangju,
      Korea.
FAU - Lee, Sangmi
AU  - Lee S
AD  - Department of Acupuncture & Moxibustion, Wonkwang Gwangju Oriental Medical
      Hospital, Gwangju, Korea ; WUGOH ALS Center of Wonkwang University, Gwangju,
      Korea.
FAU - Jeong, Hohyun
AU  - Jeong H
AD  - Department of Acupuncture & Moxibustion, Wonkwang Gwangju Oriental Medical
      Hospital, Gwangju, Korea ; WUGOH ALS Center of Wonkwang University, Gwangju,
      Korea.
FAU - Park, Manyong
AU  - Park M
AD  - Department of Acupuncture & Moxibustion, Wonkwang Gwangju Oriental Medical
      Hospital, Gwangju, Korea ; WUGOH ALS Center of Wonkwang University, Gwangju,
      Korea.
FAU - Kim, Dong-Woung
AU  - Kim DW
AD  - Department of Internal Medicine, Wonkwang Gwangju Oriental Medical Hospital,
      Gwangju, Korea.
FAU - Song, Bong-Keun
AU  - Song BK
AD  - Department of Internal Medicine, Wonkwang Gwangju Oriental Medical Hospital,
      Gwangju, Korea.
FAU - Lee, Jong-Deok
AU  - Lee JD
AD  - Department of Radiology, Wonkwang University College of Korean Medicine, Iksan,
      Korea.
FAU - Kim, Sungchul
AU  - Kim S
AD  - Department of Acupuncture & Moxibustion, Wonkwang Gwangju Oriental Medical
      Hospital, Gwangju, Korea ; WUGOH ALS Center of Wonkwang University, Gwangju,
      Korea.
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - J Pharmacopuncture
JT  - Journal of pharmacopuncture
JID - 101572812
PMC - PMC4331942
OTO - NOTNLM
OT  - Aconitum ciliare decne
OT  - Aconitum kusnezoffii Reichb. (AKR)
OT  - Aconitum pseudo-proliferum
OT  - Aconitum triphyllum Nakai
OT  - pharmacopuncture
OT  - toxicity test
EDAT- 2012/09/01 00:00
MHDA- 2012/09/01 00:01
CRDT- 2015/03/18 06:00
PHST- 2012/07/27 00:00 [received]
PHST- 2012/09/12 00:00 [accepted]
PHST- 2015/03/18 06:00 [entrez]
PHST- 2012/09/01 00:00 [pubmed]
PHST- 2012/09/01 00:01 [medline]
AID - 10.3831/KPI.2012.15.007 [doi]
PST - ppublish
SO  - J Pharmacopuncture. 2012 Sep;15(3):48-52. doi: 10.3831/KPI.2012.15.007.


PMID- 25031958
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140717
LR  - 20211021
IS  - 2150-0878 (Print)
IS  - 2150-0878 (Linking)
VI  - 3
IP  - 5
DP  - 2012 Sep
TI  - Fertility issues of breast cancer survivors.
PG  - 289-98
AB  - In the United States, more women are diagnosed with breast cancer than any other 
      type of cancer. More than 11,000 of these women will be younger than 40, and many
      of these women will want to have children in the future. A significant number of 
      these young breast cancer patients will require treatment that can cause ovarian 
      failure or premature menopause. Several options do exist for fertility
      preservation, both standard and investigational. Embryo cryopreservation is the
      most established intervention. Investigational interventions include oocyte
      cryopreservation, ovarian tissue transplantation, ovarian suppression with a
      gonadotropin-releasing hormone agonist, and harvesting of immature follicles with
      in vitro maturation and cryopreservation. Although pregnancy during cancer
      treatment is not recommended, pregnancies occurring after completion of therapy
      have not been linked to increased cancer recurrence. Young women diagnosed with
      breast cancer need evidence-based information presented in a timely manner in
      order to make decisions regarding fertility preservation prior to the initiation 
      of treatment. The oncology advanced practitioner must be knowledgeable about
      fertility preservation options available to these women as well as comfortable
      with ethical and financial concerns that can arise. The informed practitioner can
      effectively counsel patients and refer to fertility specialists when appropriate.
FAU - McClellan Misiewicz, Hollis
AU  - McClellan Misiewicz H
AD  - Mercy Medical Center, Baltimore, Maryland.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Adv Pract Oncol
JT  - Journal of the advanced practitioner in oncology
JID - 101550346
PMC - PMC4093353
EDAT- 2012/09/01 00:00
MHDA- 2012/09/01 00:01
CRDT- 2014/07/18 06:00
PHST- 2014/07/18 06:00 [entrez]
PHST- 2012/09/01 00:00 [pubmed]
PHST- 2012/09/01 00:01 [medline]
AID - 10.6004/jadpro.2012.3.5.2 [doi]
PST - ppublish
SO  - J Adv Pract Oncol. 2012 Sep;3(5):289-98. doi: 10.6004/jadpro.2012.3.5.2.


PMID- 24802781
OWN - NLM
STAT- MEDLINE
DCOM- 20150107
LR  - 20151119
IS  - 1757-9767 (Electronic)
IS  - 1757-9759 (Linking)
VI  - 19
IP  - 3
DP  - 2012 Sep
TI  - An exploration of the connection between two meaning perspectives: an
      evidence-based approach to health information delivery to vulnerable groups of
      Arabic- and Somali-speaking asylum seekers in a Swedish context.
PG  - 21-31
LID - 10.1177/1757975912453182 [doi]
AB  - The right to health care is significant for asylum seekers, particularly as many 
      of them have experienced traumatic life events in their home country, during
      flight or in their host country. Post-migration living conditions have more
      impact than pre-migration conditions on ill health among asylum seekers, which
      underscores the importance of health care-related refugee reception policies. The
      purpose of this article is to explore the perceived meaning of comprehensive
      health information provided by a nurse to Arabic- and Somali-speaking adult
      asylum seekers, in a Swedish context, during its introduction at the Migration
      Board. In our study, the endpoint was whether asylum seekers found such health
      information relevant, understandable and respectful. Following an oral
      presentation, participants filled in a questionnaire consisting of three
      close-ended questions. A total of 39 groups of presentation attendees included
      626 asylum seekers (415 Arabic- and 211 Somali-speaking). Data were analysed with
      descriptive statistics. Comments underwent content analysis. We also present some
      socio-demographic data on these asylum seekers. Independently of gender and
      language, the participants expressed their gratitude for and the meaningfulness
      of receiving professional, fact-based information, as well as being treated with 
      concern and respect. They indicated a great need for this and felt relieved by
      being listened to. They liked the pedagogic group method, the opportunity for
      dialogue and to practice exercising their rights. These promising results
      indicate that exercising the asylum-seekers' right to receive such health
      information would improve future reception policies not only in Sweden, but
      throughout the EU. A renewed focus on communication and pedagogic skills, instead
      of just cultural training, should be considered for health care professionals
      assisting asylum seekers.
FAU - Ekblad, Solvig
AU  - Ekblad S
AD  - Department LIME (learning, informatics, management and ethics), Karolinska
      Institutet, Stockholm, Sweden.
FAU - Linander, Andrea
AU  - Linander A
FAU - Asplund, Maria
AU  - Asplund M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Glob Health Promot
JT  - Global health promotion
JID - 101497462
SB  - IM
MH  - Adult
MH  - Evidence-Based Practice
MH  - Female
MH  - *Health Information Management
MH  - Health Promotion
MH  - Humans
MH  - Information Dissemination
MH  - Male
MH  - Pilot Projects
MH  - *Refugees
MH  - Somalia/ethnology
MH  - Surveys and Questionnaires
MH  - Sweden
MH  - Vulnerable Populations/*ethnology
MH  - Young Adult
OTO - NOTNLM
OT  - Arabic
OT  - Somali
OT  - Swedish Migration Board
OT  - asylum
OT  - ethics
OT  - health care policy
OT  - health literacy
OT  - health promotion
OT  - immigration
OT  - refugee empowerment
EDAT- 2012/09/01 00:00
MHDA- 2015/01/08 06:00
CRDT- 2014/05/08 06:00
PHST- 2014/05/08 06:00 [entrez]
PHST- 2012/09/01 00:00 [pubmed]
PHST- 2015/01/08 06:00 [medline]
AID - 19/3/21 [pii]
AID - 10.1177/1757975912453182 [doi]
PST - ppublish
SO  - Glob Health Promot. 2012 Sep;19(3):21-31. doi: 10.1177/1757975912453182.


PMID- 24802780
OWN - NLM
STAT- MEDLINE
DCOM- 20150107
LR  - 20151119
IS  - 1757-9767 (Electronic)
IS  - 1757-9759 (Linking)
VI  - 19
IP  - 3
DP  - 2012 Sep
TI  - Does health promotion need a Code of Ethics? Results from an IUHPE mixed method
      survey.
PG  - 8-20
LID - 10.1177/1757975912453181 [doi]
AB  - BACKGROUND: Health promotion is an ethically challenging field involving constant
      reflection of values across multiple cultures of what is regarded as good and bad
      health promotion practice. While many disciplines are guided by a Code of Ethics 
      (CoE) no such guide is available to health promoters. The International Union for
      Health Promotion and Education (IUHPE) has been nominated as a suitable candidate
      for developing such a code. It is within this context that the IUHPE Student and 
      Early Career Network (ISECN), through its Ethics Working Group, has taken up the 
      challenge of preparing the foundations for a CoE for health promotion. METHODS:
      An online survey comprising open and closed-answer questions was used to gather
      the opinions of IUHPE members regarding the need for a CoE for health promotion. 
      The quantitative data were calculated with descriptive analyses. A thematic
      analysis approach was used to analyze and interpret the qualitative data.
      RESULTS: IUHPE members (n = 236) from all global regions responded to the survey.
      The majority (52%) of the respondents had 11 years' experience or more in the
      field of health promotion. Ethical dilemmas were commonly encountered. The need
      for a CoE for health promotion was expressed by 83% of respondents. Respondents
      also offered their views of possibilities, ideas and challenges regarding the
      development of a CoE for health promotion. CONCLUSIONS: Considering that health
      promoters encounter ethical dilemmas frequently in their practice, this study
      reinforces the need to develop a CoE for the field. The recommendations from the 
      survey provide a good basis for future work to develop such a code.
FAU - Bull, Torill
AU  - Bull T
AD  - Torill Bull, Department of Health Promotion and Development, University of
      Bergen, Norway.
FAU - Riggs, Elisha
AU  - Riggs E
FAU - Nchogu, Sussy N
AU  - Nchogu SN
LA  - eng
PT  - Journal Article
PL  - England
TA  - Glob Health Promot
JT  - Global health promotion
JID - 101497462
SB  - IM
MH  - *Codes of Ethics
MH  - Health Promotion/*ethics
MH  - Humans
MH  - *Societies
MH  - Surveys and Questionnaires
OTO - NOTNLM
OT  - Code of Ethics
OT  - decision-making tools
OT  - health promotion
EDAT- 2012/09/01 00:00
MHDA- 2015/01/08 06:00
CRDT- 2014/05/08 06:00
PHST- 2014/05/08 06:00 [entrez]
PHST- 2012/09/01 00:00 [pubmed]
PHST- 2015/01/08 06:00 [medline]
AID - 19/3/8 [pii]
AID - 10.1177/1757975912453181 [doi]
PST - ppublish
SO  - Glob Health Promot. 2012 Sep;19(3):8-20. doi: 10.1177/1757975912453181.


PMID- 24712199
OWN - NLM
STAT- MEDLINE
DCOM- 20140721
LR  - 20140409
IS  - 2306-4102 (Print)
IS  - 2306-4102 (Linking)
VI  - 26
IP  - 5
DP  - 2012 Sep-Oct
TI  - [Musculoskeletal tissue banks in Mexico: behavior, management and recommendations
      on their activities].
PG  - 332-9
AB  - Tissue banks currently warrant an interdisciplinary management leading to detect 
      and address pressure conflicts taking into account ethical aspects, the safety
      and quality of the tissues provided, behavior under the principles of altruism,
      solidarity and equity, and the procurement of deceased donor tissues. This review
      article intends to inform about the main work-related and coordination aspects of
      the departments in tissue banks, and recognize their instances of sanitary
      responsibility and the bodies issuing recommendations to maintain clinical safety
      from the perspective of infection prevention and transmission of diseases related
      with musculoskeletal grafts.
FAU - Martin Alvarez-San, R
AU  - Martin Alvarez-San R
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Bancos de tejidos musculoesqueleticos en Mexico: conducta, manejo y
      recomendaciones sobre sus actividades.
PL  - Mexico
TA  - Acta Ortop Mex
JT  - Acta ortopedica mexicana
JID - 101190312
SB  - IM
MH  - *Bone and Bones
MH  - Decision Trees
MH  - Humans
MH  - Mexico
MH  - *Muscle, Skeletal
MH  - Tissue Banks/*organization & administration
EDAT- 2012/09/01 00:00
MHDA- 2014/07/22 06:00
CRDT- 2014/04/10 06:00
PHST- 2014/04/10 06:00 [entrez]
PHST- 2012/09/01 00:00 [pubmed]
PHST- 2014/07/22 06:00 [medline]
PST - ppublish
SO  - Acta Ortop Mex. 2012 Sep-Oct;26(5):332-9.


PMID- 24653870
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20211021
IS  - 2092-9862 (Print)
IS  - 2092-9862 (Linking)
VI  - 16
IP  - 2
DP  - 2012 Sep
TI  - Institutional review boards and bioethical issues for otologists and
      audiologists.
PG  - 43-6
LID - 10.7874/kja.2012.16.2.43 [doi]
AB  - Otologists and audiologists care for patients and conduct clinical research to
      find more effective treatments that benefit patients. Institutional Review Board 
      (IRB) permission is necessary for conducting clinical trials on humans.
      Furthermore, many bioethical conflicts are encountered while conducting research.
      However, few otologists and audiologists in Korea know bioethics and the
      principles and regulations of IRBs in detail. This paper reviews the history of
      ethics in clinical research and current bioethical principles and IRB
      regulations. We outline what you need as otologists or audiologists to get IRB
      approval while considering the principles of bioethics.
FAU - Park, Moo Kyun
AU  - Park MK
AD  - Department of Otorhinolayngology-Head and Neck Surgery, Bucheon Hospital,
      Soonchunhyang University College of Medicine, Bucheon, Korea.
FAU - Lee, Byung Don
AU  - Lee BD
AD  - Department of Otorhinolayngology-Head and Neck Surgery, Bucheon Hospital,
      Soonchunhyang University College of Medicine, Bucheon, Korea.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120920
PL  - Korea (South)
TA  - Korean J Audiol
JT  - Korean journal of audiology
JID - 101537216
PMC - PMC3936566
OTO - NOTNLM
OT  - Bioethics
OT  - Institutional review boards
OT  - Otologist
OT  - Research
EDAT- 2012/09/01 00:00
MHDA- 2012/09/01 00:01
CRDT- 2014/03/22 06:00
PHST- 2012/06/20 00:00 [received]
PHST- 2012/07/02 00:00 [revised]
PHST- 2012/07/03 00:00 [accepted]
PHST- 2014/03/22 06:00 [entrez]
PHST- 2012/09/01 00:00 [pubmed]
PHST- 2012/09/01 00:01 [medline]
AID - 10.7874/kja.2012.16.2.43 [doi]
PST - ppublish
SO  - Korean J Audiol. 2012 Sep;16(2):43-6. doi: 10.7874/kja.2012.16.2.43. Epub 2012
      Sep 20.


PMID- 24236879
OWN - NLM
STAT- MEDLINE
DCOM- 20140617
LR  - 20131118
IS  - 2046-8962 (Electronic)
IS  - 2046-8954 (Linking)
VI  - 1
IP  - 4
DP  - 2012 Sep
TI  - Differentiating stem cell patents.
PG  - 407-13
LID - 10.4155/ppa.12.45 [doi]
AB  - Stem cells are defined by their capability for both self-renewal through cell
      division and for producing a lineage capable of differentiating into one or more 
      specialized cell types. Stem cells are found both in adult tissues and in the
      developing embryo. While embryonic stem cells are able to differentiate into each
      and every cell type, adult stem cells are generally only able to form the cell
      types of the organ from which they originate. Stem cells are essential for the
      renewal and repair of human tissues and have been at the centre of research into 
      regenerative medicine. They have also emerged as a valuable tool for drug
      discovery and development. Strong patent protection is a crucial driver of
      investment into new stem cell technologies. However, their special nature has
      created a number of uncertainties. In particular, the biological potential of
      embryonic stem cells to create new human life raised ethical concerns and caused 
      boundaries to be set on the scope of patentability. The bar has been set at
      different places in the USA, Europe and Canada. Careful assessment of the options
      for protection in these jurisdictions is necessary in order to manage risk and
      maximize rewards. This article provides an overview of the patentability of stem 
      cells with a focus on recent developments regarding embryonic, adult and induced 
      pluripotent stem cells.
FAU - Macphie, Laurence
AU  - Macphie L
AD  - Bereskin & Parr LLP, 40 King Street West, 40th floor, Toronto, ON, M5H 3Y2,
      Canada.
FAU - Courage, Noel
AU  - Courage N
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Pharm Pat Anal
JT  - Pharmaceutical patent analyst
JID - 101582615
SB  - IM
MH  - Animals
MH  - Humans
MH  - *Patents as Topic
MH  - Regenerative Medicine
MH  - *Stem Cells
EDAT- 2012/09/01 00:00
MHDA- 2014/06/18 06:00
CRDT- 2013/11/19 06:00
PHST- 2013/11/19 06:00 [entrez]
PHST- 2012/09/01 00:00 [pubmed]
PHST- 2014/06/18 06:00 [medline]
AID - 10.4155/ppa.12.45 [doi]
PST - ppublish
SO  - Pharm Pat Anal. 2012 Sep;1(4):407-13. doi: 10.4155/ppa.12.45.


PMID- 22934000
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1663-9812 (Electronic)
IS  - 1663-9812 (Linking)
VI  - 3
DP  - 2012
TI  - Current State and Future Prospects of Direct-to-Consumer Pharmacogenetics.
PG  - 152
LID - 10.3389/fphar.2012.00152 [doi]
AB  - Direct-to-consumer (DTC) DNA testing has grown from contentious beginnings into a
      global industry, by providing a wide range of personal genomic information
      directly to its clients. These companies, typified by the well-established
      23andMe, generally carry out a gene-chip analysis of single-nucleotide
      polymorphisms (SNPs) using DNA extracted from a saliva sample. These genetic data
      are then assimilated and provided direct to the client, with varying degrees of
      interpretation. Although much debate has focused on the limitations and ethical
      aspects of providing genotypes for disease risk alleles, the provision of
      pharmacogenetic results by DTC companies is less studied. We set out to evaluate 
      current DTC pharmacogenetics offerings, and then to consider how these services
      might best evolve and adapt in order to play a potentially useful future role in 
      delivery of personalized medicine.
FAU - Chua, E W
AU  - Chua EW
AD  - Carney Centre for Pharmacogenomics, University of Otago Christchurch
      Christchurch, New Zealand.
FAU - Kennedy, M A
AU  - Kennedy MA
LA  - eng
PT  - Journal Article
DEP - 20120820
PL  - Switzerland
TA  - Front Pharmacol
JT  - Frontiers in pharmacology
JID - 101548923
PMC - PMC3422723
OTO - NOTNLM
OT  - direct-to-consumer
OT  - personal genome
OT  - personalized medicine
OT  - pharmacogenetics
OT  - pharmacogenomics
EDAT- 2012/08/31 06:00
MHDA- 2012/08/31 06:01
CRDT- 2012/08/31 06:00
PHST- 2012/06/07 00:00 [received]
PHST- 2012/07/24 00:00 [accepted]
PHST- 2012/08/31 06:00 [entrez]
PHST- 2012/08/31 06:00 [pubmed]
PHST- 2012/08/31 06:01 [medline]
AID - 10.3389/fphar.2012.00152 [doi]
PST - epublish
SO  - Front Pharmacol. 2012 Aug 20;3:152. doi: 10.3389/fphar.2012.00152. eCollection
      2012.


PMID- 22933751
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20211021
IS  - 1541-6100 (Electronic)
IS  - 0022-3166 (Linking)
VI  - 142
IP  - 10
DP  - 2012 Oct
TI  - Responsibilities to plan for ancillary care pose ethical challenges for nutrition
      research in the community setting.
PG  - 1787-90
AB  - Investigators who conduct nutrition research in the community setting,
      particularly among underserved populations, face the ethical question of whether 
      and how to respond to participants' unmet health needs. The research ethics
      literature conceptualizes this question as one of ancillary care (AC): what is
      the nature and extent of researchers' ethical responsibilities, if any, to
      provide or facilitate health care that research participants need but that is not
      necessary to ensure the safety or scientific validity of the research? In this
      paper, we highlight 3 ethical challenges involved in the planning of AC responses
      for nutrition research conducted in the community setting: influence of provision
      of AC on primary study outcomes as an issue of trial design; whether to extend
      the provision of AC beyond research participants to nonparticipants with the same
      health needs; and how best to train field workers who may be the most likely
      members of the study team to encounter the health needs anticipated among
      participants. Although the global ethical discussion of AC is gaining in depth,
      breadth, and practical influence, it remains relatively uninformed by
      perspectives specific to nutrition research. Our objective is to encourage
      nutrition researchers to engage proactively in the emerging ethical discussion of
      AC, so that their relevant experiences and concerns can be taken into account in 
      the eventual formation of ethical guidelines and policies.
FAU - Merritt, Maria W
AU  - Merritt MW
AD  - Johns Hopkins Berman Institute of Bioethics and Department of International
      Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
      mmerritt@jhsph.edu
FAU - Taylor, Holly A
AU  - Taylor HA
LA  - eng
GR  - R01 AI085147/AI/NIAID NIH HHS/United States
GR  - 1R01AI085147-01A1/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120829
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
SB  - IM
MH  - Ancillary Services, Hospital/*ethics
MH  - *Ethics, Medical
MH  - *Ethics, Research
MH  - Health Services Research/*ethics
MH  - Humans
MH  - Informed Consent
MH  - Nutrition Assessment
MH  - Research Personnel
PMC - PMC3442792
EDAT- 2012/08/31 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/08/31 06:00
PHST- 2012/08/31 06:00 [entrez]
PHST- 2012/08/31 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - jn.111.155382 [pii]
AID - 10.3945/jn.111.155382 [doi]
PST - ppublish
SO  - J Nutr. 2012 Oct;142(10):1787-90. doi: 10.3945/jn.111.155382. Epub 2012 Aug 29.


PMID- 22933644
OWN - NLM
STAT- MEDLINE
DCOM- 20130211
LR  - 20170322
IS  - 1464-3685 (Electronic)
IS  - 0300-5771 (Linking)
VI  - 41
IP  - 4
DP  - 2012 Aug
TI  - Cohort profile: the QSkin Sun and Health Study.
PG  - 929-929i
AB  - The QSkin Sun and Health Study comprises a cohort of 43 794 men and women aged
      40-69 years randomly sampled from the population of Queensland, Australia in
      2011. The cohort was established to study the development of skin cancer and
      melanoma in the population with the highest reported incidence of these diseases 
      in the world. At baseline, besides demographic items and general medical history,
      information about standard pigmentary characteristics (including hair and eye
      colour, freckling tendency, tanning ability and propensity to sunburn), past and 
      recent history of sun exposure and sunburns, sun protection behaviours, use of
      tanning beds and history of skin cancer was collected by self-completed
      questionnaire. Participants have given their consent for data linkage to the
      universal national health insurance scheme and for linkage to cancer registries
      and pathology databases, thus ensuring complete ascertainment of all future skin 
      cancer and melanoma occurrences and medical treatments and other cancer events.
      Linkage to these registers will occur at predetermined intervals. Approval to
      access QSkin data can be obtained on application to the study investigators and
      submission of a formal research plan that has previous approval from the human
      research ethics committee of the applicant's institution.
FAU - Olsen, Catherine M
AU  - Olsen CM
AD  - Population Health Department, Queensland Institute of Medical Research,
      Queensland, Australia and University of Manchester, Manchester Academic Health
      Sciences Centre, Manchester, UK. Catherine.Olsen@qimr.edu.au
FAU - Green, Adele C
AU  - Green AC
FAU - Neale, Rachel E
AU  - Neale RE
FAU - Webb, Penelope M
AU  - Webb PM
FAU - Cicero, Rebekah A
AU  - Cicero RA
FAU - Jackman, Lea M
AU  - Jackman LM
FAU - O'Brien, Suzanne M
AU  - O'Brien SM
FAU - Perry, Susan L
AU  - Perry SL
FAU - Ranieri, Barbara A
AU  - Ranieri BA
FAU - Whiteman, David C
AU  - Whiteman DC
CN  - QSkin Study
LA  - eng
GR  - 89912/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Epidemiol
JT  - International journal of epidemiology
JID - 7802871
SB  - IM
MH  - Adult
MH  - Aged
MH  - Attitude to Health
MH  - Cohort Studies
MH  - Demography
MH  - Female
MH  - *Health Behavior
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Melanoma/*epidemiology/*prevention & control
MH  - Middle Aged
MH  - Queensland/epidemiology
MH  - Registries
MH  - Research Design
MH  - Risk Assessment
MH  - Risk Factors
MH  - Skin Neoplasms/*epidemiology/*prevention & control
MH  - Surveys and Questionnaires
IR  - Whiteman DC
FIR - Whiteman, David C
IR  - Olsen CM
FIR - Olsen, Catherine M
IR  - Green AC
FIR - Green, Adele C
IR  - Neale RE
FIR - Neale, Rachel E
IR  - Webb PM
FIR - Webb, Penelope M
IR  - Cicero RA
FIR - Cicero, Rebekah A
IR  - Jackman LM
FIR - Jackman, Lea M
IR  - O'Brien SM
FIR - O'Brien, Suzanne M
IR  - Perry SL
FIR - Perry, Susan L
IR  - Ranieri BA
FIR - Ranieri, Barbara A
IR  - Morze CJ
FIR - Morze, Conrad J
IR  - Soyer PH
FIR - Soyer, Peter H
IR  - English D
FIR - English, Dallas
IR  - Venn A
FIR - Venn, Alison
IR  - McFadyen L
FIR - McFadyen, Lisa
EDAT- 2012/08/31 06:00
MHDA- 2013/02/12 06:00
CRDT- 2012/08/31 06:00
PHST- 2012/08/31 06:00 [entrez]
PHST- 2012/08/31 06:00 [pubmed]
PHST- 2013/02/12 06:00 [medline]
AID - dys107 [pii]
AID - 10.1093/ije/dys107 [doi]
PST - ppublish
SO  - Int J Epidemiol. 2012 Aug;41(4):929-929i. doi: 10.1093/ije/dys107.


PMID- 22932653
OWN - NLM
STAT- MEDLINE
DCOM- 20121130
LR  - 20211203
IS  - 1175-8716 (Electronic)
IS  - 0028-8446 (Linking)
VI  - 125
IP  - 1360
DP  - 2012 Aug 24
TI  - The Christchurch Breast Cancer Patient Register: the first year.
PG  - 37-47
AB  - AIMS: The aim of this article is to present the first year's findings of the
      Christchurch Breast Cancer Patient Register (CBCR) to establish the incidence and
      management of breast cancer in the Canterbury region. METHODS: CBCR commenced
      recruitment of breast cancer patients in Canterbury from June 2009. Ethical
      approval was granted by regional ethics committees to collect data. Patient data 
      is recorded onto the database once informed consent is obtained. RESULTS: A total
      of 337 patients (including one male) consented. At diagnosis, 231 (68.5%) were
      aged 50 years or over. 48 (14.2%) patients had carcinoma in situ with no invasive
      component. 289 (85.8%) patients had invasive carcinoma with 47.4% undergoing
      mastectomy and 44.6% breast conserving surgery whereas 8% had no primary surgery.
      Nodes were positive in 102 (38.8%), and the predominant tumour type was Ductal
      NST (no special type) in 68.9% (199) of patients with invasive carcinoma.
      Additional data incorporating ethnicity, oncology, additional surgical management
      and pathological variables are also presented in detail. CONCLUSION: Findings on 
      337 patients recruited and recorded on CBCR database in the first year are
      discussed. Due to the short follow up, outcome data is not analysed.
FAU - Davey, Valerie
AU  - Davey V
AD  - Christchurch Breast Cancer Patient Register, c/o Dept of Surgery, Christchurch
      Hospital, Private Bag 4710, Christchurch 8140, New Zealand.
      valerie.davey@cdhb.health.nz
FAU - Robinson, Bridget
AU  - Robinson B
FAU - Dijkstra, Birgit
AU  - Dijkstra B
FAU - Harris, Gavin
AU  - Harris G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120824
PL  - New Zealand
TA  - N Z Med J
JT  - The New Zealand medical journal
JID - 0401067
RN  - 0 (Antibodies, Monoclonal, Humanized)
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Antineoplastic Agents, Hormonal)
RN  - P188ANX8CK (Trastuzumab)
SB  - IM
CIN - N Z Med J. 2012 Aug 24;125(1360):9-10. PMID: 22932650
MH  - Adult
MH  - Age Distribution
MH  - Aged
MH  - Aged, 80 and over
MH  - Antibodies, Monoclonal, Humanized/therapeutic use
MH  - Antineoplastic Agents/therapeutic use
MH  - Antineoplastic Agents, Hormonal/therapeutic use
MH  - Breast Neoplasms/epidemiology/*pathology/*therapy
MH  - Carcinoma in Situ/epidemiology/pathology/therapy
MH  - Carcinoma, Ductal, Breast/epidemiology/pathology/therapy
MH  - Carcinoma, Lobular/epidemiology/pathology/therapy
MH  - Ethnicity/statistics & numerical data
MH  - Female
MH  - Humans
MH  - Lymph Nodes/pathology
MH  - Male
MH  - Mastectomy/statistics & numerical data
MH  - Mastectomy, Segmental/statistics & numerical data
MH  - Middle Aged
MH  - Neoadjuvant Therapy
MH  - Neoplasm Invasiveness
MH  - Neoplasm Staging
MH  - New Zealand/epidemiology
MH  - Radiotherapy, Adjuvant
MH  - Registries
MH  - Sentinel Lymph Node Biopsy/statistics & numerical data
MH  - Trastuzumab
EDAT- 2012/08/31 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/08/31 06:00
PHST- 2012/08/31 06:00 [entrez]
PHST- 2012/08/31 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
PST - epublish
SO  - N Z Med J. 2012 Aug 24;125(1360):37-47.


PMID- 22932033
OWN - NLM
STAT- MEDLINE
DCOM- 20121101
LR  - 20121219
IS  - 1538-7488 (Electronic)
IS  - 0002-936X (Linking)
VI  - 112
IP  - 9
DP  - 2012 Sep
TI  - The ethics of authorship.
PG  - 7
FAU - Kennedy, Maureen Shawn
AU  - Kennedy MS
FAU - Roush, Karen
AU  - Roush K
FAU - Barnsteiner, Jane
AU  - Barnsteiner J
LA  - eng
PT  - Editorial
PL  - United States
TA  - Am J Nurs
JT  - The American journal of nursing
JID - 0372646
SB  - IM
MH  - *Authorship
MH  - Editorial Policies
MH  - Humans
MH  - Nursing Research
MH  - Periodicals as Topic/*ethics
MH  - Publishing/*ethics
MH  - United States
EDAT- 2012/08/31 06:00
MHDA- 2012/11/02 06:00
CRDT- 2012/08/31 06:00
PHST- 2012/08/31 06:00 [entrez]
PHST- 2012/08/31 06:00 [pubmed]
PHST- 2012/11/02 06:00 [medline]
AID - 10.1097/01.NAJ.0000418903.33925.93 [doi]
AID - 00000446-201209000-00001 [pii]
PST - ppublish
SO  - Am J Nurs. 2012 Sep;112(9):7. doi: 10.1097/01.NAJ.0000418903.33925.93.


PMID- 22932015
OWN - NLM
STAT- MEDLINE
DCOM- 20130404
LR  - 20160607
IS  - 0578-1310 (Print)
IS  - 0578-1310 (Linking)
VI  - 50
IP  - 7
DP  - 2012 Jul
TI  - [Preliminary establishment of cytological examination and the normal reference
      values for hypertonic saline solution-induced sputum of healthy children in
      Guangzhou].
PG  - 525-30
AB  - OBJECTIVE: To establish the method of cytological examination and the normal
      reference values for hypertonic saline solution-induced sputum of healthy
      children (age range from 5 to 15 years) with physical examination in Guangzhou.
      METHOD: A total of 352 children, 5 to 15 years old, were enrolled from primary
      school and middle school in Guangzhou from January to December, 2010. All
      subjects completed a standardized questionnaire on the presence of respiratory,
      allergic symptoms and family history, the medical history and the physical
      examination was performed by doctors, lung function (forced expiratory volume at 
      1 s in predicted normal, FEV(1)%) was determined. There were 266 healthy children
      (137 males, 129 females) who were selected and undergone hypertonic saline
      solution induction of sputum, and cytological examination was performed.
      Hypertonic saline (5%) was nebulized and inhaled for 15 - 30 min. No
      expectoration within 30 min was defined as failure, and the procedure was
      terminated. The part of opaque and higher density sputum samples was detected by 
      cytology. The proportion of neutrophils, lymphocytes, eosinophils, macrophages
      and monocytes was calculated. This study was approved by the institutional Ethics
      Review Committee of First Affiliated Hospital of Guangzhou Medical College.
      Informed consent was obtained from the legal guardians of all participants
      following a detailed description of the purpose and potential benefits of the
      study. RESULT: There were 175 subjects' induced sputum specimens (175/266,
      65.8%), non-qualified sputum samples were obtained from 16 of the subjects. The
      proportions of median (IQR) of lymphocytes were 0.012 (0.020), 95%CI were ranged 
      from 0.015 to 0.022; neutrophils 0.207 (0.330), 95%CI 0.266 - 0.356 macrophages
      0.761 (0.327), 95%CI 0.607 - 0.699; eosinophils 0.004 (0.019), 95%CI 0.013 -
      0.022. There were no significant differences in proportions of cytological
      findings of female or male, different age groups and second-hand smoking or not
      (all P > 0.05). The incidence of adverse event was 4.40% (7/159). CONCLUSION: The
      method and the preliminary data may be used for research, diagnosis and treatment
      of patients with chronic cough and airway inflammation.
FAU - Chen, De-hui
AU  - Chen DH
AD  - Department of Pediatrics, the First Affiliated Hospital of Guangzhou Medical
      College, Guangzhou, China.
FAU - Zhong, Guo-yu
AU  - Zhong GY
FAU - Luo, Wei
AU  - Luo W
FAU - Chen, Qiao-li
AU  - Chen QL
FAU - Chen, Ru-chong
AU  - Chen RC
FAU - Lin, Yu-neng
AU  - Lin YN
FAU - Pan, Xiao-an
AU  - Pan XA
FAU - Li, Jin-ying
AU  - Li JY
FAU - Wu, Shang-zhi
AU  - Wu SZ
FAU - Lai, Ke-fang
AU  - Lai KF
FAU - Zhong, Nan-shan
AU  - Zhong NS
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Er Ke Za Zhi
JT  - Zhonghua er ke za zhi = Chinese journal of pediatrics
JID - 0417427
RN  - 0 (Saline Solution, Hypertonic)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - China
MH  - Cough/diagnosis/physiopathology
MH  - Eosinophils/cytology
MH  - Female
MH  - Forced Expiratory Volume
MH  - Humans
MH  - Leukocyte Count
MH  - Lymphocyte Count
MH  - Lymphocytes/cytology
MH  - Male
MH  - Monocytes/*cytology
MH  - Neutrophils/*cytology
MH  - Reference Values
MH  - *Saline Solution, Hypertonic/chemistry
MH  - Sputum/*cytology/metabolism
EDAT- 2012/08/31 06:00
MHDA- 2013/04/05 06:00
CRDT- 2012/08/31 06:00
PHST- 2012/08/31 06:00 [entrez]
PHST- 2012/08/31 06:00 [pubmed]
PHST- 2013/04/05 06:00 [medline]
PST - ppublish
SO  - Zhonghua Er Ke Za Zhi. 2012 Jul;50(7):525-30.


PMID- 22931481
OWN - NLM
STAT- MEDLINE
DCOM- 20130130
LR  - 20210916
IS  - 1745-7599 (Electronic)
IS  - 1041-2972 (Linking)
VI  - 24
IP  - 9
DP  - 2012 Sep
TI  - Clarifying, affirming, and preserving the nurse in nurse practitioner education
      and practice.
PG  - 554-64
LID - 10.1111/j.1745-7599.2012.00738.x [doi]
AB  - PURPOSE: This work responds to the need for maintaining an ethic of care in the
      face of increased demands for cost effectiveness and efficiency. Findings are
      presented from a qualitative study describing how nurse practitioner (NP) faculty
      teach NP students about holistic nursing dimensions of NP practice. DATA
      RESOURCES: Data collection consisted of face to face or telephone interviews with
      24 experienced NP faculty members teaching in 22 NP programs across the country. 
      Data were analyzed using the interpretive phenomenological approach. Aspects of
      scientific merit were addressed through reviewing transcripts for accuracy,
      consensual validation sessions, and member checking. CONCLUSIONS: The most common
      approaches used for teaching holistic nursing dimensions of NP practice were role
      modeling and sharing narratives of actual cases. Other approaches included:
      incorporation of holistic complementary diagnoses along with medical diagnoses
      into assessments, use of case scenarios and standardized patients, a rite of
      passage ceremony, and an entire narrative curriculum. IMPLICATIONS FOR PRACTICE: 
      NP faculty advocate incorporating a holistic mind-body-spirit perspective into
      assessment and intervention and broadening the diagnostic process to include
      complementary components of nursing and medicine. Findings have implications for 
      teaching/learning, curriculum planning, and evaluation as NP programs transition 
      from the master's to the doctoral level.
CI  - (c)2012 The Author(s) Journal compilation (c)2012 American Academy of Nurse
      Practitioners.
FAU - Brykczynski, Karen
AU  - Brykczynski K
AD  - University of Texas Medical Branch School of Nursing, Galveston, TX 77555, USA.
      kbrykczy@utmb.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120420
PL  - United States
TA  - J Am Acad Nurse Pract
JT  - Journal of the American Academy of Nurse Practitioners
JID - 8916634
MH  - *Clinical Competence
MH  - Curriculum
MH  - Educational Status
MH  - Faculty, Nursing
MH  - Health Knowledge, Attitudes, Practice
MH  - *Holistic Nursing
MH  - Humans
MH  - Leadership
MH  - Mind-Body Therapies
MH  - Nurse Practitioners/*education
MH  - *Nurses
MH  - *Practice Patterns, Physicians'
MH  - Qualitative Research
MH  - Students, Nursing
EDAT- 2012/08/31 06:00
MHDA- 2013/01/31 06:00
CRDT- 2012/08/31 06:00
PHST- 2012/08/31 06:00 [entrez]
PHST- 2012/08/31 06:00 [pubmed]
PHST- 2013/01/31 06:00 [medline]
AID - 10.1111/j.1745-7599.2012.00738.x [doi]
PST - ppublish
SO  - J Am Acad Nurse Pract. 2012 Sep;24(9):554-64. doi:
      10.1111/j.1745-7599.2012.00738.x. Epub 2012 Apr 20.


PMID- 22931391
OWN - NLM
STAT- MEDLINE
DCOM- 20131022
LR  - 20220321
IS  - 1365-2648 (Electronic)
IS  - 0309-2402 (Linking)
VI  - 69
IP  - 6
DP  - 2013 Jun
TI  - Differences between clinical specialist and advanced practitioner clinical
      practice, leadership, and research roles, responsibilities, and perceived
      outcomes (the SCAPE study).
PG  - 1323-37
LID - 10.1111/j.1365-2648.2012.06124.x [doi]
AB  - AIM: To report a study designed comparing the roles, responsibilities, and
      perceived outcomes of Clinical Nurse Specialists, Clinical Midwife Specialists,
      and Advanced Nurse Practitioners in Ireland. BACKGROUND: A clinical career
      pathway that encompasses progression from staff nurse or midwife through clinical
      specialist to advanced practitioner level was introduced in Ireland in 2000. Such
      roles are common internationally, but little evaluation has been conducted and
      few comparisons have been made between roles. DESIGN: A mixed-method case-study
      design was used. METHODS: Following Research Ethics Committee Approval, data were
      collected in 2009-2010, using non-participant observation (92 hours) of 23
      Clinical Specialists and Advanced Practitioners, interviews with 21 clinicians
      and 13 Directors of Nursing or Midwifery. A survey was completed by 154
      service-users. RESULTS: A clear difference was seen between Clinical Specialist
      and Advanced Practitioners, with advanced practice roles providing improved
      service delivery, greater clinical and professional leadership, increased
      research, and a clear governance and accreditation structure. Clinical Midwife
      Specialists were rated at a similar level to Advanced Nurse Practitioners for
      certain aspects and rated more highly for 'continuity of care and carer'.
      CONCLUSION: Advanced Practitioners do give a higher level of care, particularly
      at a strategic level. Existing Clinical Specialists should therefore be
      encouraged to develop their skills and education to achieve advanced practice
      level and more specialist and advanced practice posts should be instituted.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Begley, Cecily
AU  - Begley C
AD  - School of Nursing and Midwifery, Trinity College Dublin, Ireland. cbegley@tcd.ie
FAU - Elliott, Naomi
AU  - Elliott N
FAU - Lalor, Joan
AU  - Lalor J
FAU - Coyne, Imelda
AU  - Coyne I
FAU - Higgins, Agnes
AU  - Higgins A
FAU - Comiskey, Catherine M
AU  - Comiskey CM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120829
PL  - England
TA  - J Adv Nurs
JT  - Journal of advanced nursing
JID - 7609811
SB  - IM
MH  - Adult
MH  - Empirical Research
MH  - Female
MH  - Humans
MH  - Ireland
MH  - Leadership
MH  - Male
MH  - Nurse Clinicians/*standards
MH  - Nurse Midwives/*standards
MH  - Nurse Practitioners/*standards
MH  - Nurse's Role
MH  - Nursing Research
MH  - Professional Autonomy
MH  - Surveys and Questionnaires
EDAT- 2012/08/31 06:00
MHDA- 2013/10/23 06:00
CRDT- 2012/08/31 06:00
PHST- 2012/07/21 00:00 [accepted]
PHST- 2012/08/31 06:00 [entrez]
PHST- 2012/08/31 06:00 [pubmed]
PHST- 2013/10/23 06:00 [medline]
AID - 10.1111/j.1365-2648.2012.06124.x [doi]
PST - ppublish
SO  - J Adv Nurs. 2013 Jun;69(6):1323-37. doi: 10.1111/j.1365-2648.2012.06124.x. Epub
      2012 Aug 29.


PMID- 22931081
OWN - NLM
STAT- MEDLINE
DCOM- 20130116
LR  - 20211021
IS  - 1097-9891 (Electronic)
IS  - 0095-2990 (Linking)
VI  - 38
IP  - 5
DP  - 2012 Sep
TI  - Umyuangcaryaraq "Reflecting": multidimensional assessment of reflective processes
      on the consequences of alcohol use among rural Yup'ik Alaska Native youth.
PG  - 468-75
LID - 10.3109/00952990.2012.702169 [doi]
AB  - BACKGROUND AND AIMS: Concerns in some settings regarding the accuracy and ethics 
      of employing direct questions about alcohol use suggest need for alternative
      assessment approaches with youth. Umyuangcaryaraq is a Yup'ik Alaska Native word 
      meaning "Reflecting." OBJECTIVES: The Reflective Processes Scale was developed as
      a youth measure tapping awareness and thinking over potential negative
      consequences of alcohol misuse as a protective factor that includes cultural
      elements often shared by many other Alaska Native and American Indian cultures.
      This study assessed multidimensional structure, item functioning, and validity.
      METHODS: Responses from 284 rural Alaska Native youth allowed bifactor analysis
      to assess structure, estimates of location and discrimination parameters, and
      convergent and discriminant validity. RESULTS: A bifactor model of the scale
      items with three content factors provided excellent fit to observed data. Item
      response theory analysis suggested a binary response format as optimal. Evidence 
      of convergent and discriminant validity was established. CONCLUSION: The measure 
      provides an assessment of reflective processes about alcohol that Alaska Native
      youth engage in when thinking about reasons not to drink. SCIENTIFIC
      SIGNIFICANCE: The concept of reflective processes has potential to extend
      understandings of cultural variation in mindfulness, alcohol expectancies
      research, and culturally mediated protective factors in Alaska Native and
      American Indian youth.
FAU - Allen, James
AU  - Allen J
AD  - Department of Biobehavioral Health and Population Sciences, University of
      Minnesota Medical School, Duluth Campus, Duluth, MN 55812, USA. jallen@d.umn.edu
FAU - Fok, Carlotta Ching Ting
AU  - Fok CC
FAU - Henry, David
AU  - Henry D
FAU - Skewes, Monica
AU  - Skewes M
CN  - People Awakening Team
LA  - eng
GR  - R21AA0016098/AA/NIAAA NIH HHS/United States
GR  - R01 AA011446/AA/NIAAA NIH HHS/United States
GR  - P20 RR016430/RR/NCRR NIH HHS/United States
GR  - R21 AA016098/AA/NIAAA NIH HHS/United States
GR  - R24MD001626/MD/NIMHD NIH HHS/United States
GR  - R24 MD001626/MD/NIMHD NIH HHS/United States
GR  - P20RR061430/RR/NCRR NIH HHS/United States
GR  - R21AA015541/AA/NIAAA NIH HHS/United States
GR  - R21 AA015541/AA/NIAAA NIH HHS/United States
GR  - R01AA11446/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Validation Study
PL  - England
TA  - Am J Drug Alcohol Abuse
JT  - The American journal of drug and alcohol abuse
JID - 7502510
SB  - IM
MH  - Adolescent
MH  - Alaska/epidemiology
MH  - Alcohol Drinking/epidemiology/ethnology/*psychology
MH  - Alcohol-Related Disorders/epidemiology/ethnology/*psychology
MH  - Awareness
MH  - Child
MH  - Cultural Characteristics
MH  - Data Collection
MH  - Female
MH  - Humans
MH  - Inuits/*psychology
MH  - Male
MH  - Models, Theoretical
MH  - Rural Population
PMC - PMC3476469
MID - NIHMS409271
IR  - Agimuk S
FIR - Agimuk, Sophie
IR  - Asuluk H
FIR - Asuluk, Harry
IR  - Asuluk T
FIR - Asuluk, Thomas
IR  - Bentley TJ
FIR - Bentley, T J
IR  - Carl J
FIR - Carl, John
IR  - Carl M
FIR - Carl, Mary
IR  - Chagluk E
FIR - Chagluk, Emily
IR  - Charlie J Sr
FIR - Charlie, James Sr
IR  - Chimiugak L
FIR - Chimiugak, Lizzie
IR  - Jimmie R
FIR - Jimmie, Ruth
IR  - John J
FIR - John, Jolene
IR  - John P
FIR - John, Paul
IR  - John S
FIR - John, Simeon
IR  - Moses A
FIR - Moses, Aaron
IR  - Moses P
FIR - Moses, Phillip
IR  - Tulik H
FIR - Tulik, Harry
IR  - White C
FIR - White, Cecelia
IR  - Agayar C
FIR - Agayar, Catherine
IR  - Augustine F
FIR - Augustine, Fred
IR  - Augustine M
FIR - Augustine, Mary
IR  - Ayunerak P
FIR - Ayunerak, Paula
IR  - Damian T
FIR - Damian, Theresa
IR  - Edmund L Sr
FIR - Edmund, Lawrence Sr
IR  - Joe B
FIR - Joe, Barbara
IR  - Joseph L
FIR - Joseph, Lucy
IR  - Joseph J
FIR - Joseph, Joe
IR  - Joseph P
FIR - Joseph, Placide
IR  - Paul Z
FIR - Paul, Zacheus
IR  - Phillp C
FIR - Phillp, Charlotte
IR  - Phillip H
FIR - Phillip, Henry
IR  - Phillip J
FIR - Phillip, Joe
IR  - Alstrom P
FIR - Alstrom, Penny
IR  - Augustine F
FIR - Augustine, Fred
IR  - Augustine M
FIR - Augustine, Mary
IR  - Ayunerak P
FIR - Ayunerak, Paula
IR  - Damian T
FIR - Damian, Theresa
IR  - Edmund S
FIR - Edmund, Shelby
IR  - Patrick F
FIR - Patrick, Flora
IR  - Sheldon D
FIR - Sheldon, Dennis
IR  - Shelton I
FIR - Shelton, Isidore
IR  - Agayar C
FIR - Agayar, Catherine
IR  - Damian T
FIR - Damian, Theresa
IR  - Edmund F
FIR - Edmund, Freddie
IR  - Edmund S
FIR - Edmund, Shelby
IR  - Edmund J
FIR - Edmund, Josie
IR  - Patrick F
FIR - Patrick, Flora
IR  - Simon M
FIR - Simon, Martha
IR  - Tulim M
FIR - Tulim, Moses
IR  - Adams E
FIR - Adams, Ed
IR  - Aguchak T
FIR - Aguchak, Tammy
IR  - Ayunerak P
FIR - Ayunerak, Paula
IR  - Cowboy S
FIR - Cowboy, Sebastian
IR  - Edmunds L
FIR - Edmunds, Lawrence
IR  - Harpak M
FIR - Harpak, Margaret
IR  - Moses C
FIR - Moses, Charles
IR  - Oney R
FIR - Oney, Raymond
IR  - Charles W
FIR - Charles, Walkie
IR  - Katz R
FIR - Katz, Richard
IR  - Sexton M
FIR - Sexton, Mary
IR  - Thomas LR
FIR - Thomas, Lisa Rey
IR  - Thompson B
FIR - Thompson, Beti
IR  - Trickett E
FIR - Trickett, Edison
IR  - Alstrom D
FIR - Alstrom, Debbie
IR  - Blackhurst C
FIR - Blackhurst, Carl
IR  - Burkett R
FIR - Burkett, Rebekah
IR  - Campbell D
FIR - Campbell, Diana
IR  - Chikigak A
FIR - Chikigak, Arthur
IR  - Ebbesson G
FIR - Ebbesson, Gunnar
IR  - Fortner A
FIR - Fortner, Aaron
IR  - Gonzalez J
FIR - Gonzalez, John
IR  - Hopkins S
FIR - Hopkins, Scarlett
IR  - Hubalik N
FIR - Hubalik, Nick
IR  - Klejka J
FIR - Klejka, Joseph
IR  - Moses C
FIR - Moses, Charles
IR  - Nicholai D
FIR - Nicholai, Dora
IR  - Orr E
FIR - Orr, Eliza
IR  - Paul M
FIR - Paul, Marvin
IR  - Dondanville M
FIR - Dondanville, Michelle
IR  - Kim J
FIR - Kim, Jonghan
IR  - Koskela R
FIR - Koskela, Rebecca
IR  - Herron J
FIR - Herron, Johanna
IR  - Rasmus S
FIR - Rasmus, Stacy
IR  - Charles B
FIR - Charles, Billy
EDAT- 2012/08/31 06:00
MHDA- 2013/01/17 06:00
CRDT- 2012/08/31 06:00
PHST- 2012/08/31 06:00 [entrez]
PHST- 2012/08/31 06:00 [pubmed]
PHST- 2013/01/17 06:00 [medline]
AID - 10.3109/00952990.2012.702169 [doi]
PST - ppublish
SO  - Am J Drug Alcohol Abuse. 2012 Sep;38(5):468-75. doi:
      10.3109/00952990.2012.702169.


PMID- 22931015
OWN - NLM
STAT- MEDLINE
DCOM- 20121004
LR  - 20170214
IS  - 0840-4704 (Print)
IS  - 0840-4704 (Linking)
VI  - 25
IP  - 2
DP  - 2012 Summer
TI  - The ethics of disclosure of patient safety incidents.
PG  - 120-5
FAU - Simpson, Christy
AU  - Simpson C
AD  - Christy.Simpson@DAL.ca
FAU - Aubin, Diane
AU  - Aubin D
FAU - Fillatre, Theresa
AU  - Fillatre T
LA  - eng
LA  - fre
PT  - Journal Article
PL  - United States
TA  - Healthc Manage Forum
JT  - Healthcare management forum
JID - 8805307
MH  - Canada
MH  - Disclosure/*ethics
MH  - Humans
MH  - *Medical Errors
MH  - *Patient Safety
EDAT- 2012/08/31 06:00
MHDA- 2012/10/05 06:00
CRDT- 2012/08/31 06:00
PHST- 2012/08/31 06:00 [entrez]
PHST- 2012/08/31 06:00 [pubmed]
PHST- 2012/10/05 06:00 [medline]
AID - 10.1016/j.hcmf.2012.04.003 [doi]
PST - ppublish
SO  - Healthc Manage Forum. 2012 Summer;25(2):120-5. doi: 10.1016/j.hcmf.2012.04.003.


PMID- 22930939
OWN - NLM
STAT- MEDLINE
DCOM- 20121016
LR  - 20120830
IS  - 0024-3477 (Print)
IS  - 0024-3477 (Linking)
VI  - 134
IP  - 5-6
DP  - 2012 May-Jun
TI  - [The lower Neretva basin as a pathological topos: press reports and
      politicization of the memories of the age of cholera in 1886].
PG  - 186-91
AB  - The lower Neretva basin as a space that has undergone historical transformation
      into a myth of a pathological topos has been analyzed. Starting from the fact
      that temporality is essential for understanding of the elements that partake in
      conceptualization of a myth, we have analyzed the state of this area as it was
      during its exposure to an epidemic of cholera in 1886. There is evidence that at 
      this time exactly a step forward was made in comprehension of the etiology of the
      disease, which resulted in the change of centuries-long concepts of the Neretva
      basin as an unhealthy area. In this paper the Neretva basin was understood and
      presented as a field of unfolding of all kinds of transformations, a habitat
      exposed to manifold social arrangements, lushly documented in newspapers and
      other printed material. The arguments about the natural disaster in these texts
      are ethically and politically coloured, which to a large extent corresponds to
      the vocabulary of current print media on similar occasions. Thus, the area of the
      Neretva basin imposes itself as a multilayered anthropological concept, a
      multi-semantic ecologically and socially constituted reality, within which
      history functions as a valuable source of knowledge pliable to contemporary
      usage.
FAU - Fatovic-Ferencic, Stella
AU  - Fatovic-Ferencic S
AD  - Odsjek za povijest medicinskih znanosti, HAZU, Zagreb. stella@hazu.hr
FAU - Wokaunn, Mario
AU  - Wokaunn M
LA  - hrv
PT  - English Abstract
PT  - Historical Article
PT  - Journal Article
TT  - Poneretvlje kao patoloski topos: tisak I politizacija sjecanja na doba kolere
      1886. g.
PL  - Croatia
TA  - Lijec Vjesn
JT  - Lijecnicki vjesnik
JID - 0074253
SB  - IM
MH  - Cholera/*history
MH  - Croatia
MH  - Epidemics/*history
MH  - History, 19th Century
MH  - Humans
EDAT- 2012/08/31 06:00
MHDA- 2012/10/17 06:00
CRDT- 2012/08/31 06:00
PHST- 2012/08/31 06:00 [entrez]
PHST- 2012/08/31 06:00 [pubmed]
PHST- 2012/10/17 06:00 [medline]
PST - ppublish
SO  - Lijec Vjesn. 2012 May-Jun;134(5-6):186-91.


PMID- 22930712
OWN - NLM
STAT- MEDLINE
DCOM- 20121226
LR  - 20181023
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 345
DP  - 2012 Aug 28
TI  - German ethics council backs religious circumcision if specific conditions met.
PG  - e5789
LID - 10.1136/bmj.e5789 [doi]
LID - bmj.e5789 [pii]
FAU - Stafford, Ned
AU  - Stafford N
LA  - eng
PT  - News
DEP - 20120828
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
SB  - IM
MH  - *Circumcision, Male/ethics/ethnology
MH  - Ethics Committees/*legislation & jurisprudence
MH  - Germany/ethnology
MH  - Government Regulation
MH  - Humans
MH  - *Islam
MH  - *Judaism
MH  - Male
MH  - *Religion and Medicine
EDAT- 2012/08/30 06:00
MHDA- 2012/12/27 06:00
CRDT- 2012/08/30 06:00
PHST- 2012/08/30 06:00 [entrez]
PHST- 2012/08/30 06:00 [pubmed]
PHST- 2012/12/27 06:00 [medline]
AID - 10.1136/bmj.e5789 [doi]
PST - epublish
SO  - BMJ. 2012 Aug 28;345:e5789. doi: 10.1136/bmj.e5789.


PMID- 22930676
OWN - NLM
STAT- MEDLINE
DCOM- 20141010
LR  - 20201209
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 40
IP  - 2
DP  - 2014 Feb
TI  - Is prostitution harmful?
PG  - 73-81
LID - 10.1136/medethics-2011-100367 [doi]
AB  - A common argument against prostitution states that selling sex is harmful because
      it involves selling something deeply personal and emotional. More and more of us,
      however, believe that sexual encounters need not be deeply personal and emotional
      in order to be acceptable--we believe in the acceptability of casual sex. In this
      paper I argue that if casual sex is acceptable, then we have few or no reasons to
      reject prostitution. I do so by first examining nine influential arguments to the
      contrary. These arguments purport to pin down the alleged additional harm brought
      about by prostitution (compared to just casual sex) by appealing to various
      aspects of its practice, such as its psychology, physiology, economics and social
      meaning. For each argument I explain why it is unconvincing. I then weight the
      costs against the benefits of prostitution, and argue that, in sum, prostitution 
      is no more harmful than a long line of occupations that we commonly accept
      without hesitation.
FAU - Moen, Ole Martin
AU  - Moen OM
LA  - eng
PT  - Journal Article
DEP - 20120828
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
CIN - J Med Ethics. 2014 Feb;40(2):83. PMID: 22942372
CIN - J Med Ethics. 2014 Feb;40(2):82-3. PMID: 22942375
CIN - J Med Ethics. 2014 Feb;40(2):84-5. PMID: 23698889
CIN - J Med Ethics. 2014 Feb;40(2):86-7. PMID: 23760729
CIN - J Med Ethics. 2014 Feb;40(2):88. PMID: 24335659
MH  - *Attitude
MH  - *Commodification
MH  - Health Knowledge, Attitudes, Practice
MH  - *Human Body
MH  - Humans
MH  - Income
MH  - Poverty
MH  - *Psychological Distance
MH  - *Sex Work/psychology
MH  - Sexual Behavior/*ethics
MH  - Social Marginalization
MH  - *Social Perception
MH  - Social Problems
MH  - Social Stigma
OTO - NOTNLM
OT  - Applied and Professional Ethics
OT  - Occupational Health
OT  - Public Policy
OT  - Sexuality/Gender
OT  - Social Aspects
EDAT- 2012/08/30 06:00
MHDA- 2014/10/11 06:00
CRDT- 2012/08/30 06:00
PHST- 2012/08/30 06:00 [entrez]
PHST- 2012/08/30 06:00 [pubmed]
PHST- 2014/10/11 06:00 [medline]
AID - medethics-2011-100367 [pii]
AID - 10.1136/medethics-2011-100367 [doi]
PST - ppublish
SO  - J Med Ethics. 2014 Feb;40(2):73-81. doi: 10.1136/medethics-2011-100367. Epub 2012
      Aug 28.


PMID- 22930675
OWN - NLM
STAT- MEDLINE
DCOM- 20130227
LR  - 20181202
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 12
DP  - 2012 Dec
TI  - Scarce vaccine supplies in an influenza pandemic should not be distributed
      randomly: reply to McLachlan.
PG  - 765-7
LID - 10.1136/medethics-2012-100750 [doi]
AB  - In a recent paper, Hugh McLachlan argues from a deontological perspective that
      the most ethical means of distributing scarce supplies of an effective vaccine in
      the context of an influenza pandemic would be via an equal lottery. I argue that,
      even if one accepts McLachlan's ethical theory, it does not follow that one
      should accept the vaccine lottery. McLachlan's argument relies upon two
      suppressed premises which, I maintain, one need not accept; and it misconstrues
      vaccination programmes as clinical interventions targeted solely at protecting
      the health of vaccinated individuals, rather than as public health interventions 
      targeted at protecting the health of the population as a whole.
FAU - Wardrope, Alistair
AU  - Wardrope A
AD  - The Medical School, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, 
      UK. ajbwardrope1@sheffield.ac.uk
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20120828
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
RN  - 0 (Influenza Vaccines)
SB  - IM
CON - J Med Ethics. 2012 May;38(5):317-8. PMID: 22411748
CIN - J Med Ethics. 2015 Feb;41(2):191-4. PMID: 24143004
MH  - Health Care Rationing/*ethics
MH  - *Health Policy
MH  - Humans
MH  - Influenza Vaccines/*administration & dosage/*supply & distribution
MH  - Influenza, Human/*prevention & control
MH  - *Pandemics
MH  - *Social Justice
EDAT- 2012/08/30 06:00
MHDA- 2013/02/28 06:00
CRDT- 2012/08/30 06:00
PHST- 2012/08/30 06:00 [entrez]
PHST- 2012/08/30 06:00 [pubmed]
PHST- 2013/02/28 06:00 [medline]
AID - medethics-2012-100750 [pii]
AID - 10.1136/medethics-2012-100750 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Dec;38(12):765-7. doi: 10.1136/medethics-2012-100750. Epub
      2012 Aug 28.


PMID- 22930470
OWN - NLM
STAT- MEDLINE
DCOM- 20130528
LR  - 20171116
IS  - 1097-0258 (Electronic)
IS  - 0277-6715 (Linking)
VI  - 31
IP  - 30
DP  - 2012 Dec 30
TI  - Estimation of secondary endpoints in two-stage phase II oncology trials.
PG  - 4352-68
LID - 10.1002/sim.5585 [doi]
AB  - In the development of a new treatment in oncology, phase II trials play a key
      role. On the basis of the data obtained during phase II, it is decided whether
      the treatment should be studied further. Therefore, the decision to be made on
      the basis of the data of a phase II trial must be as accurate as possible. For
      ethical and economic reasons, phase II trials are usually performed with a
      planned interim analysis. Furthermore, the decision about stopping or continuing 
      the study is usually based on a short-term outcome like tumor response, whereas
      secondary endpoints comprise stable disease, progressive disease, toxicity,
      and/or overall survival. The data obtained in a phase II trial are often analyzed
      and interpreted by applying the maximum likelihood estimator (MLE) without taking
      into account the sequential nature of the trial. However, this approach provides 
      biased results and may therefore lead to wrong conclusions. Whereas unbiased
      estimators for two-stage designs have been derived for the primary endpoint, such
      estimators are currently not available for secondary endpoints. We present
      uniformly minimum variance unbiased estimators (UMVUE) for secondary endpoints in
      two-stage designs that allow stopping for futility (and efficacy). We compare the
      mean squared error of the UMVUE and the MLE and investigate the efficiency of the
      UMVUE. A clinical trial example illustrates the application.
CI  - Copyright (c) 2012 John Wiley & Sons, Ltd.
FAU - Kunz, Cornelia Ursula
AU  - Kunz CU
AD  - Institute of Medical Biometry and Informatics, University of Heidelberg,
      Heidelberg, Germany. c.u.kunz@warwick.ac.uk
FAU - Kieser, Meinhard
AU  - Kieser M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120829
PL  - England
TA  - Stat Med
JT  - Statistics in medicine
JID - 8215016
SB  - IM
MH  - *Bias
MH  - Clinical Trials, Phase II as Topic/*methods/statistics & numerical data
MH  - *Endpoint Determination
MH  - Epidemiologic Research Design
MH  - Humans
MH  - Medical Oncology/*methods/statistics & numerical data
EDAT- 2012/08/30 06:00
MHDA- 2013/05/29 06:00
CRDT- 2012/08/30 06:00
PHST- 2011/10/25 00:00 [received]
PHST- 2012/07/27 00:00 [accepted]
PHST- 2012/08/30 06:00 [entrez]
PHST- 2012/08/30 06:00 [pubmed]
PHST- 2013/05/29 06:00 [medline]
AID - 10.1002/sim.5585 [doi]
PST - ppublish
SO  - Stat Med. 2012 Dec 30;31(30):4352-68. doi: 10.1002/sim.5585. Epub 2012 Aug 29.


PMID- 22929938
OWN - NLM
STAT- MEDLINE
DCOM- 20121030
LR  - 20121213
IS  - 0807-7096 (Electronic)
IS  - 0029-2001 (Linking)
VI  - 132
IP  - 15
DP  - 2012 Aug 21
TI  - [Research ethics, truth and love].
PG  - 1731-2
LID - 10.4045/tidsskr.12.0704 [doi]
FAU - Meland, Eivind
AU  - Meland E
AD  - Institutt for samfunnsmedisinske fag, Universitetet i Bergen, Norway.
      eivind.meland@isf.uib.no
LA  - nor
PT  - Journal Article
TT  - Forskningsetikk, sannhet og kjaerlighet.
PL  - Norway
TA  - Tidsskr Nor Laegeforen
JT  - Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny
      raekke
JID - 0413423
SB  - IM
CIN - Tidsskr Nor Laegeforen. 2012 Oct 16;132(19):2146; author reply 2146. PMID:
      23076472
MH  - *Ethics, Research
MH  - Humans
MH  - Love
MH  - *Morals
MH  - Plagiarism
MH  - Scientific Misconduct/*ethics
EDAT- 2012/08/30 06:00
MHDA- 2012/10/31 06:00
CRDT- 2012/08/30 06:00
PHST- 2012/08/30 06:00 [entrez]
PHST- 2012/08/30 06:00 [pubmed]
PHST- 2012/10/31 06:00 [medline]
AID - 2815496 [pii]
AID - 10.4045/tidsskr.12.0704 [doi]
PST - ppublish
SO  - Tidsskr Nor Laegeforen. 2012 Aug 21;132(15):1731-2. doi: 10.4045/tidsskr.12.0704.


PMID- 22929635
OWN - NLM
STAT- MEDLINE
DCOM- 20130122
LR  - 20181201
IS  - 1999-6217 (Electronic)
IS  - 1727-5482 (Linking)
VI  - 10
IP  - 1
DP  - 2012 Jan
TI  - Status of pathology professionals.
PG  - 37-40
AB  - BACKGROUND: The status of basic, general and specialist workforces in pathology
      services in Nepal needs to be defined and explored for better pathology services.
      The objective of the study was to find out the status of laboratory medicine
      professionals (pathology workforces) and the regulation of ethics and limitations
      of the different level of workforces. METHODS: A cross-sectional descriptive
      study was conducted by observing and taking interview with the head of the
      clinical private institutions from August 2008 to January 2009. A total of 373
      private pathology laboratories and the workforces working over there were
      included in the study. RESULTS: The workforces heading private pathology services
      showed that 153 (41%) of laboratories were headed by laboratory assistant, 79
      (21%) by laboratory technician, 90 (24%) by (medical technologist) pathology
      officer, 30 (8%) by histocytopathologist and 21 (6%) by non pathology
      professionals. Officer level Pathology workforce (eligible to work independently)
      was 113 (30%) whereas 260 (70%) of laboratories had no such workforces.
      Intermediate level Pathology workforce (eligible to work dependently and for some
      investigation independently) was 34% (127/373) where as 66% (246/373) of
      laboratories were lacking such workforces. Specialist level (MD/M. Sc) workforces
      in histocytopathology, clinical microbiology and cytopatholgy & hematology were
      43 (11%), 10 (3%) and 3 (1%) respectively. CONCLUSIONS: The workforces heading
      the private laboratories were not according to the norms of good laboratory
      practices. The workforces had crossed their limitations and ethical barrier in
      performing pathological investigations which did not abide by the rules and
      regulations made by respective councils of Nepal by pathology workforces. There
      was intervention of non medical/clinical workforce in laboratory services
      especially in microbiology and biochemistry.
FAU - Mishra, S K
AU  - Mishra SK
AD  - Concern for Public Health Development (C-PHD), Kathmandu, Nepal.
      shravanmishra11@yahoo.com
FAU - Tiwari, B R
AU  - Tiwari BR
FAU - Yadav, B K
AU  - Yadav BK
LA  - eng
PT  - Journal Article
PL  - Nepal
TA  - J Nepal Health Res Counc
JT  - Journal of Nepal Health Research Council
JID - 101292936
SB  - IM
CIN - J Nepal Health Res Counc. 2012 May;10(21):173-5. PMID: 23034384
MH  - Cross-Sectional Studies
MH  - Humans
MH  - *Laboratories/ethics/standards
MH  - Nepal
MH  - *Pathology, Clinical/ethics/standards
MH  - Qualitative Research
MH  - Specialization
MH  - Workforce
EDAT- 2012/08/30 06:00
MHDA- 2013/01/23 06:00
CRDT- 2012/08/30 06:00
PHST- 2012/08/30 06:00 [entrez]
PHST- 2012/08/30 06:00 [pubmed]
PHST- 2013/01/23 06:00 [medline]
PST - ppublish
SO  - J Nepal Health Res Counc. 2012 Jan;10(1):37-40.


PMID- 22929604
OWN - NLM
STAT- MEDLINE
DCOM- 20130114
LR  - 20211021
IS  - 1532-8635 (Electronic)
IS  - 1524-9042 (Linking)
VI  - 13
IP  - 3
DP  - 2012 Sep
TI  - American Society for Pain Management nursing position statement: pain management 
      in patients with substance use disorders.
PG  - 169-83
LID - 10.1016/j.pmn.2012.07.001 [doi]
AB  - The American Society for Pain Management Nursing (ASPMN) has updated its position
      statement on managing pain in patients with substance use disorders. This
      position statement is endorsed by the International Nurses Society on Addictions 
      (IntNSA) and includes clinical practice recommendations based on current
      evidence. It is the position of ASPMN and IntNSA that every patient with pain,
      including those with substance use disorders, has the right to be treated with
      dignity, respect, and high-quality pain assessment and management. Failure to
      identify and treat the concurrent conditions of pain and substance use disorders 
      will compromise the ability to treat either condition effectively. Barriers to
      caring for these patients include stigmatization, misconceptions, and limited
      access to providers skilled in these two categories of disorders. Topics
      addressed in this position statement include the scope of substance use and
      related disorders, conceptual models of addiction, ethical considerations,
      addiction risk stratification, and clinical recommendations.
CI  - Copyright (c) 2012 International Nursing Society on Addiction (IntNSA) and the
      American Society for Pain Management Nursing (ASPMN). Published by Elsevier Inc. 
      All rights reserved.
FAU - Oliver, June
AU  - Oliver J
AD  - Swedish Covenant Hospital, Chicago, IL, USA.
FAU - Coggins, Candace
AU  - Coggins C
FAU - Compton, Peggy
AU  - Compton P
FAU - Hagan, Susan
AU  - Hagan S
FAU - Matteliano, Deborah
AU  - Matteliano D
FAU - Stanton, Marsha
AU  - Stanton M
FAU - St Marie, Barbara
AU  - St Marie B
FAU - Strobbe, Stephen
AU  - Strobbe S
FAU - Turner, Helen N
AU  - Turner HN
LA  - eng
GR  - T32 NR011147/NR/NINR NIH HHS/United States
PT  - Consensus Development Conference
PT  - Journal Article
PL  - United States
TA  - Pain Manag Nurs
JT  - Pain management nursing : official journal of the American Society of Pain
      Management Nurses
JID - 100890606
SB  - IM
CIN - Pain Manag Nurs. 2012 Sep;13(3):125-6. PMID: 22929599
MH  - Humans
MH  - Pain/*drug therapy/*nursing
MH  - Pain Management/*nursing/*standards
MH  - *Practice Guidelines as Topic
MH  - Societies, Nursing/standards
MH  - Substance-Related Disorders/*nursing
MH  - United States
PMC - PMC3741053
MID - NIHMS485563
EDAT- 2012/08/30 06:00
MHDA- 2013/01/15 06:00
CRDT- 2012/08/30 06:00
PHST- 2012/06/29 00:00 [received]
PHST- 2012/07/01 00:00 [accepted]
PHST- 2012/08/30 06:00 [entrez]
PHST- 2012/08/30 06:00 [pubmed]
PHST- 2013/01/15 06:00 [medline]
AID - S1524-9042(12)00089-6 [pii]
AID - 10.1016/j.pmn.2012.07.001 [doi]
PST - ppublish
SO  - Pain Manag Nurs. 2012 Sep;13(3):169-83. doi: 10.1016/j.pmn.2012.07.001.


PMID- 22929586
OWN - NLM
STAT- MEDLINE
DCOM- 20130401
LR  - 20211203
IS  - 1479-5876 (Electronic)
IS  - 1479-5876 (Linking)
VI  - 10
DP  - 2012 Aug 28
TI  - Tracking the impact of translational research in psychiatry: state of the art and
      perspectives.
PG  - 175
LID - 10.1186/1479-5876-10-175 [doi]
AB  - Personalized treatments have become a primary goal in translational psychiatric
      research. They include the identification of neural circuits associated with
      psychiatric disorders and definition of treatment according to individual
      characteristics. Many new tools and technologies have been developed but further 
      efforts are required to provide clues on how these scientific advances in
      psychiatry may be translated into more effective therapeutic approaches.
      Obstacles to the progress of translational psychiatry also involve numerous
      scientific, financial, ethical, logistics and regulatory aspects. Also, the goal 
      of DSM-5 to expand "signs and symptoms" classification to incorporate biological 
      measures may help the development of new multifactorial and dimensional models
      able to better understand the pathophysiology of psychiatric disorders and
      develop improved treatments. Finally, a better understanding on the significant
      response variability, cognitive functioning, role of comorbidities and
      treatment-resistant cases are critical for the development of prevention and
      intervention strategies that are more effective.
FAU - Machado-Vieira, Rodrigo
AU  - Machado-Vieira R
AD  - Institute and Department of Psychiatry, Laboratory of Neuroscience, LIM27,
      University of Sao Paulo, Rua Ovidio Pires de Campos, 785, Sao Paulo, SP, Brazil. 
      machadovieirar@gmail.com
LA  - eng
PT  - Editorial
DEP - 20120828
PL  - England
TA  - J Transl Med
JT  - Journal of translational medicine
JID - 101190741
SB  - IM
MH  - Humans
MH  - *Psychiatry
MH  - *Translational Research, Biomedical
PMC - PMC3533752
EDAT- 2012/08/30 06:00
MHDA- 2013/04/02 06:00
CRDT- 2012/08/30 06:00
PHST- 2012/06/04 00:00 [received]
PHST- 2012/08/16 00:00 [accepted]
PHST- 2012/08/30 06:00 [entrez]
PHST- 2012/08/30 06:00 [pubmed]
PHST- 2013/04/02 06:00 [medline]
AID - 1479-5876-10-175 [pii]
AID - 10.1186/1479-5876-10-175 [doi]
PST - epublish
SO  - J Transl Med. 2012 Aug 28;10:175. doi: 10.1186/1479-5876-10-175.


PMID- 22929334
OWN - NLM
STAT- MEDLINE
DCOM- 20130103
LR  - 20211021
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 265
IP  - 2
DP  - 2012 Nov
TI  - Systolic myocardial dysfunction in patients with type 2 diabetes mellitus:
      identification at MR imaging with cine displacement encoding with stimulated
      echoes.
PG  - 402-9
LID - 10.1148/radiol.12112571 [doi]
AB  - PURPOSE: To determine if cine displacement encoding with stimulated echoes
      (DENSE) can help to identify and determine the patterns of subclinical myocardial
      systolic dysfunction in patients with type 2 diabetes mellitus (DM) when compared
      with cine DENSE in control patients. MATERIALS AND METHODS: After obtaining
      approval from the institutional ethics committee and written informed consent
      from the patients, 37 patients with type 2 DM without overt heart disease and 23 
      age-matched control patients were prospectively included in the study. The
      patients underwent standard cine magnetic resonance (MR) imaging with
      two-dimensional cine DENSE acquisitions. Circumferential (Ecc) and radial (Err)
      systolic strains were measured on short-axis views at basal, mid, and apical left
      ventricular levels. Longitudinal strain (Ell) was measured on four- and
      two-chamber views. Statistical testing included the intraclass correlation
      coefficient and multiple linear regression analysis. RESULTS: The intraobserver
      intraclass correlation coefficient values were 0.85, 0.95, and 0.90, and the
      interobserver intraclass correlation coefficient values were 0.79, 0.91 and 0.80 
      for Ecc, Err, and Ell, respectively. The left ventricular ejection fraction was
      in the reference range and similar between the groups, and the patients with DM
      showed a decrease in Ecc (-14.4%+/-1.6 vs -17.0%+/-1.6, P<.001), Err
      (36.2%+/-10.9 vs 44.4%+/-9.9, P=.006) and Ell (-12.9%+/-2.1 vs -15.5%+/-1.6,
      P<.001) compared with the control patients. Finally, DM was independently
      associated with Ecc (P<.001), Err (P=.05) and Ell (P=.01) after adjustment for
      age, sex, hypertension, body mass index, and left ventricular mass. CONCLUSION:
      Cine DENSE, a motion-encoding MR imaging technique for myocardial strain
      assessment with high spatial resolution, appears to be useful in the
      identification of subclinical myocardial dysfunction in patients with DM.
CI  - (c) RSNA, 2012
FAU - Ernande, Laura
AU  - Ernande L
AD  - Service des Explorations Fonctionnelles Cardiovasculaires, Department of
      Endocrinology, Louis Pradel Hospital, CarMeN INSERM Unit 1060, Universite de
      Lyon, Lyon, France.
FAU - Thibault, Helene
AU  - Thibault H
FAU - Bergerot, Cyrille
AU  - Bergerot C
FAU - Moulin, Phillippe
AU  - Moulin P
FAU - Wen, Han
AU  - Wen H
FAU - Derumeaux, Genevieve
AU  - Derumeaux G
FAU - Croisille, Pierre
AU  - Croisille P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120828
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Algorithms
MH  - Diabetes Mellitus, Type 2/*complications/*diagnosis
MH  - Female
MH  - Humans
MH  - Image Enhancement/methods
MH  - Image Interpretation, Computer-Assisted/*methods
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Stroke Volume
MH  - Ventricular Dysfunction, Left/*diagnosis/*etiology
PMC - PMC3480812
EDAT- 2012/08/30 06:00
MHDA- 2013/01/04 06:00
CRDT- 2012/08/30 06:00
PHST- 2012/08/30 06:00 [entrez]
PHST- 2012/08/30 06:00 [pubmed]
PHST- 2013/01/04 06:00 [medline]
AID - radiol.12112571 [pii]
AID - 10.1148/radiol.12112571 [doi]
PST - ppublish
SO  - Radiology. 2012 Nov;265(2):402-9. doi: 10.1148/radiol.12112571. Epub 2012 Aug 28.


PMID- 22929333
OWN - NLM
STAT- MEDLINE
DCOM- 20130103
LR  - 20121024
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 265
IP  - 2
DP  - 2012 Nov
TI  - Liver: segment-specific analysis of B1 field homogeneity at 3.0-T MR imaging with
      single-source versus dual-source parallel radiofrequency excitation.
PG  - 591-9
LID - 10.1148/radiol.12112715 [doi]
AB  - PURPOSE: To measure B1 field distribution in different liver segments with and
      without dual transmission and to quantify the contrast-to-noise ratio (CNR)
      between normal liver tissue and segmental venous vessels on standard clinical
      3.0-T liver magnetic resonance (MR) images. MATERIALS AND METHODS: This
      prospective study was approved by the local ethics committee. All subjects gave
      written informed consent. Six patients with liver lesions and nine healthy
      volunteers were included. Average hepatic B1 field values in all Couinaud liver
      segments were assessed by using actual flip-angle imaging (first and second
      repetition times msec/echo time msec: 72, 192/2.2; transmission angle: 60 degrees
      ) for both single and dual transmission in a 3.0-T MR imaging unit that allowed
      both transmission modes. Additionally, two-dimensional T1-weighted gradient-echo 
      (repetition time msec/echo time msec, 180/2.3; transmission angle, 55 degrees )
      and T2-weighted single-shot fast spin-echo images (1501/80) were acquired.
      Average CNR between liver parenchyma and segmental veins were measured in each
      segment. Two-sided paired Student t tests were used for statistical evaluation.
      Two blinded radiologists independently identified lesions in images from
      acquisitions in both transmission modes. RESULTS: Mean flip angles achieved with 
      conventional single transmission were 44%-53% of the nominal value in segments
      II-IV and 67% and 63% of the nominal value in segments VI and VII, respectively, 
      and were less than 77% in all segments. Mean actual flip angles measured for dual
      transmission were between 82% and 100% of the nominal value in all segments.
      T1-weighted single-transmission images exhibited areas of low B1 field strength
      with reduced image contrast. T2-weighted single-transmission images displayed
      significantly reduced signal intensity but nearly unchanged contrast weighting in
      these areas. On T1-weighted dual-transmission images, the two readers detected 22
      and 14 additional lesions that they did not identify on the single-transmission
      images. On the dual-transmission T2-weighted images, they detected 11 and five
      additional lesions, respectively. CONCLUSION: Dual transmission can generate a B1
      field with significantly improved homogeneity over all liver segments at a field 
      strength of 3.0 T.
CI  - (c) RSNA, 2012
FAU - Pazahr, Shila
AU  - Pazahr S
AD  - Department of Diagnostic and Interventional Radiology, University Hospital
      Zurich, Institute for Biomedical Engineering, University and ETH Zurich, Zurich, 
      Switzerland. shila.pazahr@usz.ch
FAU - Fischer, Michael Alexander
AU  - Fischer MA
FAU - Chuck, Natalie
AU  - Chuck N
FAU - Luechinger, Roger
AU  - Luechinger R
FAU - Schick, Fritz
AU  - Schick F
FAU - Nanz, Daniel
AU  - Nanz D
FAU - Boss, Andreas
AU  - Boss A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20120828
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Algorithms
MH  - Humans
MH  - Image Enhancement/*methods
MH  - Image Interpretation, Computer-Assisted/*methods
MH  - Liver/*pathology
MH  - Liver Neoplasms/*pathology
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Radio Waves
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
EDAT- 2012/08/30 06:00
MHDA- 2013/01/04 06:00
CRDT- 2012/08/30 06:00
PHST- 2012/08/30 06:00 [entrez]
PHST- 2012/08/30 06:00 [pubmed]
PHST- 2013/01/04 06:00 [medline]
AID - radiol.12112715 [pii]
AID - 10.1148/radiol.12112715 [doi]
PST - ppublish
SO  - Radiology. 2012 Nov;265(2):591-9. doi: 10.1148/radiol.12112715. Epub 2012 Aug 28.


PMID- 22929331
OWN - NLM
STAT- MEDLINE
DCOM- 20130103
LR  - 20220408
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 265
IP  - 2
DP  - 2012 Nov
TI  - Pulmonary perifissural nodules on CT scans: rapid growth is not a predictor of
      malignancy.
PG  - 611-6
LID - 10.1148/radiol.12112351 [doi]
AB  - PURPOSE: To assess the prevalence, natural course, and malignancy rate of
      perifissural nodules (PFNs) in smokers participating in a lung cancer screening
      trial. MATERIALS AND METHODS: As part of the ethics-committee approved
      Dutch-Belgian Randomised Lung Cancer Multi-Slice Screening Trial (NELSON),
      computed tomography (CT) was used to screen 2994 current or former heavy smokers,
      aged 50-74 years, for lung cancer. CT was repeated after 1 and 3 years, with
      additional follow-up CT scans if necessary. All baseline CT scans were screened
      for nodules. Nodule volume was determined with automated volumetric analysis.
      Homogeneous solid nodules, attached to a fissure with a lentiform or triangular
      shape, were classified as PFNs. Nodules were considered benign if they did not
      grow during the total follow-up period or were proved to be benign in a follow-up
      by a pulmonologist. Prevalence, growth, and malignancy rate of PFNs were
      assessed. RESULTS: At baseline screening, 4026 nodules were detected in 1729
      participants, and 19.7% (794 of 4026) of the nodules were classified as PFNs. The
      mean size of the PFNs was 4.4 mm (range: 2.8-10.6 mm) and the mean volume was 43 
      mm3 (range: 13-405 mm3). None of the PFNs were found to be malignant during
      follow-up. Between baseline and the first follow-up CT scan, 15.5% (123 of 794)
      were found to have grown, and 8.3% (66 of 794) had a volume doubling time of less
      than 400 days. One PFN was resected and proved to be a lymph node. CONCLUSION:
      PFNs are frequently found at CT scans for lung cancer. They can show growth rates
      in the range of malignant nodules, but none of the PFNs in the present study
      turned out to be malignant. Recognition of PFNs can reduce the number of
      follow-up examinations required for the workup of suspicious nodules.
CI  - (c) RSNA, 2012
FAU - de Hoop, Bartjan
AU  - de Hoop B
AD  - Department of Radiology, Rijnstate Hospital, Wagnerlaan 55, 6815 AD, Arnhem, the 
      Netherlands. BdeHoop@rijnstate.nl
FAU - van Ginneken, Bram
AU  - van Ginneken B
FAU - Gietema, Hester
AU  - Gietema H
FAU - Prokop, Mathias
AU  - Prokop M
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20120828
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Aged
MH  - Causality
MH  - Comorbidity
MH  - Female
MH  - Humans
MH  - Imaging, Three-Dimensional/statistics & numerical data
MH  - Lung Neoplasms/*diagnostic imaging/*epidemiology
MH  - Male
MH  - Mass Screening/statistics & numerical data
MH  - Middle Aged
MH  - Netherlands/epidemiology
MH  - Prevalence
MH  - Prognosis
MH  - Smoking/*epidemiology
MH  - Solitary Pulmonary Nodule/*epidemiology
MH  - Tomography, X-Ray Computed/*statistics & numerical data
EDAT- 2012/08/30 06:00
MHDA- 2013/01/04 06:00
CRDT- 2012/08/30 06:00
PHST- 2012/08/30 06:00 [entrez]
PHST- 2012/08/30 06:00 [pubmed]
PHST- 2013/01/04 06:00 [medline]
AID - radiol.12112351 [pii]
AID - 10.1148/radiol.12112351 [doi]
PST - ppublish
SO  - Radiology. 2012 Nov;265(2):611-6. doi: 10.1148/radiol.12112351. Epub 2012 Aug 28.


PMID- 22929200
OWN - NLM
STAT- MEDLINE
DCOM- 20130123
LR  - 20120829
IS  - 1550-1841 (Electronic)
IS  - 0741-5206 (Linking)
VI  - 32
IP  - 3
DP  - 2012 Jul-Aug
TI  - Scope of practice...standard of practice...standard of care...what is my/your
      obligation?
PG  - 120-2
LID - 10.1097/PSN.0b013e3182650697 [doi]
AB  - You are required by law, regulatory agencies, and ethical standards to deliver
      care within your scope of practice and to adhere to recognized standards of care 
      while doing so. To comply with these mandates, you must also understand the scope
      of practice of those practitioners around you that comprise the plastic surgical 
      team, as well as your responsibilities that flow therefrom.
FAU - Wilhite, C Leigh
AU  - Wilhite CL
AD  - leighwilhite@gmail.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Plast Surg Nurs
JT  - Plastic surgical nursing : official journal of the American Society of Plastic
      and Reconstructive Surgical Nurses
JID - 8403490
MH  - Humans
MH  - *Legislation, Nursing
MH  - Nursing Care/*standards
MH  - *Standard of Care
MH  - United States
EDAT- 2012/08/30 06:00
MHDA- 2013/01/24 06:00
CRDT- 2012/08/30 06:00
PHST- 2012/08/30 06:00 [entrez]
PHST- 2012/08/30 06:00 [pubmed]
PHST- 2013/01/24 06:00 [medline]
AID - 10.1097/PSN.0b013e3182650697 [doi]
AID - 00006527-201207000-00010 [pii]
PST - ppublish
SO  - Plast Surg Nurs. 2012 Jul-Aug;32(3):120-2. doi: 10.1097/PSN.0b013e3182650697.


PMID- 22929062
OWN - NLM
STAT- MEDLINE
DCOM- 20130411
LR  - 20211021
IS  - 1748-717X (Electronic)
IS  - 1748-717X (Linking)
VI  - 7
DP  - 2012 Aug 28
TI  - Phase I-II study of hypofractionated simultaneous integrated boost using
      volumetric modulated arc therapy for adjuvant radiation therapy in breast cancer 
      patients: a report of feasibility and early toxicity results in the first 50
      treatments.
PG  - 145
LID - 10.1186/1748-717X-7-145 [doi]
AB  - BACKGROUND: To report results in terms of feasibility and early toxicity of
      hypofractionated simultaneous integrated boost (SIB) approach with Volumetric
      Modulated Arc Therapy (VMAT) as adjuvant treatment after breast-conserving
      surgery. METHODS: Between September 2010 and May 2011, 50 consecutive patients
      presenting early-stage breast cancer were submitted to adjuvant radiotherapy with
      SIB-VMAT approach using RapidArc in our Institution (Istituto Clinico Humanitas
      ICH). Three out of 50 patients were irradiated bilaterally (53 tumours in 50
      patients). All patients were enrolled in a phase I-II trial approved by the ICH
      ethical committee. All 50 patients enrolled in the study underwent VMAT-SIB
      technique to irradiate the whole breast with concomitant boost irradiation of the
      tumor bed. Doses to whole breast and surgical bed were 40.5 Gy and 48 Gy
      respectively, delivered in 15 fractions over 3 weeks. Skin toxicities were
      recorded during and after treatment according to RTOG acute radiation morbidity
      scoring criteria with a median follow-up of 12 months (range 8-16). Cosmetic
      outcomes were assessed as excellent/good or fair/poor. RESULTS: The median age of
      the population was 68 years (range 36-88). According to AJCC staging system, 38
      breast lesions were classified as pT1, and 15 as pT2; 49 cases were assessed as
      N0 and 4 as N1. The maximum acute skin toxicity by the end of treatment was Grade
      0 in 20/50 patients, Grade 1 in 32/50, Grade 2 in 0 and Grade 3 in 1/50 (one of
      the 3 cases of bilateral breast irradiation). No Grade 4 toxicities were
      observed. All Grade 1 toxicities had resolved within 3 weeks. No significant
      differences in cosmetic scores on baseline assessment vs. 3 months and 6 months
      after the treatment were observed: all patients were scored as excellent/good
      (50/50) compared with baseline; no fair/poor judgment was recorded. No other
      toxicities or local failures were recorded during follow-up. CONCLUSIONS: The
      3-week course of postoperative radiation using VMAT with SIB showed to be
      feasible and was associated with acceptable acute skin toxicity profile.
      Long-term follow-up data are needed to assess late toxicity and clinical
      outcomes.
FAU - Scorsetti, Marta
AU  - Scorsetti M
AD  - Radiotherapy and radiosurgery, Humanitas Cancer Center, Istituto Clinico
      Humanitas, Rozzano, Milano, Italy.
FAU - Alongi, Filippo
AU  - Alongi F
FAU - Fogliata, Antonella
AU  - Fogliata A
FAU - Pentimalli, Sara
AU  - Pentimalli S
FAU - Navarria, Pierina
AU  - Navarria P
FAU - Lobefalo, Francesca
AU  - Lobefalo F
FAU - Garcia-Etienne, Carlos
AU  - Garcia-Etienne C
FAU - Clivio, Alessandro
AU  - Clivio A
FAU - Cozzi, Luca
AU  - Cozzi L
FAU - Mancosu, Pietro
AU  - Mancosu P
FAU - Nicolini, Giorgia
AU  - Nicolini G
FAU - Vanetti, Eugenio
AU  - Vanetti E
FAU - Eboli, Marco
AU  - Eboli M
FAU - Rossetti, Carlo
AU  - Rossetti C
FAU - Rubino, Arianna
AU  - Rubino A
FAU - Sagona, Andrea
AU  - Sagona A
FAU - Arcangeli, Stefano
AU  - Arcangeli S
FAU - Gatzemeier, Wolfgang
AU  - Gatzemeier W
FAU - Masci, Giovanna
AU  - Masci G
FAU - Torrisi, Rosalba
AU  - Torrisi R
FAU - Testori, Alberto
AU  - Testori A
FAU - Alloisio, Marco
AU  - Alloisio M
FAU - Santoro, Armando
AU  - Santoro A
FAU - Tinterri, Corrado
AU  - Tinterri C
LA  - eng
PT  - Journal Article
DEP - 20120828
PL  - England
TA  - Radiat Oncol
JT  - Radiation oncology (London, England)
JID - 101265111
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Breast Neoplasms/pathology/*radiotherapy
MH  - Carcinoma, Ductal, Breast/pathology/*radiotherapy
MH  - Carcinoma, Lobular/pathology/*radiotherapy
MH  - *Dose Fractionation, Radiation
MH  - Feasibility Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Middle Aged
MH  - Neoplasm Grading
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Radiation Injuries/*etiology
MH  - Radiotherapy, Adjuvant
MH  - Radiotherapy, Intensity-Modulated/*adverse effects
PMC - PMC3488023
EDAT- 2012/08/30 06:00
MHDA- 2013/04/12 06:00
CRDT- 2012/08/30 06:00
PHST- 2012/03/27 00:00 [received]
PHST- 2012/07/25 00:00 [accepted]
PHST- 2012/08/30 06:00 [entrez]
PHST- 2012/08/30 06:00 [pubmed]
PHST- 2013/04/12 06:00 [medline]
AID - 1748-717X-7-145 [pii]
AID - 10.1186/1748-717X-7-145 [doi]
PST - epublish
SO  - Radiat Oncol. 2012 Aug 28;7:145. doi: 10.1186/1748-717X-7-145.


PMID- 22929055
OWN - NLM
STAT- MEDLINE
DCOM- 20130125
LR  - 20211021
IS  - 1940-087X (Electronic)
IS  - 1940-087X (Linking)
IP  - 66
DP  - 2012 Aug 21
TI  - The use of cystometry in small rodents: a study of bladder chemosensation.
PG  - e3869
LID - 10.3791/3869 [doi]
LID - 3869 [pii]
AB  - The lower urinary tract (LUT) functions as a dynamic reservoir that is able to
      store urine and to efficiently expel it at a convenient time. While storing
      urine, however, the bladder is exposed for prolonged periods to waste products.
      By acting as a tight barrier, the epithelial lining of the LUT, the urothelium,
      avoids re-absorption of harmful substances. Moreover, noxious chemicals stimulate
      the bladder's nociceptive innervation and initiate voiding contractions that
      expel the bladder's contents. Interestingly, the bladder's sensitivity to noxious
      chemicals has been used successfully in clinical practice, by intravesically
      infusing the TRPV1 agonist capsaicin to treat neurogenic bladder overactivity.
      This underscores the advantage of viewing the bladder as a chemosensory organ and
      prompts for further clinical research. However, ethical issues severely limit the
      possibilities to perform, in human subjects, the invasive measurements that are
      necessary to unravel the molecular bases of LUT clinical pharmacology. A way to
      overcome this limitation is the use of several animal models. Here we describe
      the implementation of cystometry in mice and rats, a technique that allows
      measuring the intravesical pressure in conditions of controlled bladder
      perfusion. After laparotomy, a catheter is implanted in the bladder dome and
      tunneled subcutaneously to the interscapular region. Then the bladder can be
      filled at a controlled rate, while the urethra is left free for micturition.
      During the repetitive cycles of filling and voiding, intravesical pressure can be
      measured via the implanted catheter. As such, the pressure changes can be
      quantified and analyzed. Moreover, simultaneous measurement of the voided volume 
      allows distinguishing voiding contractions from non-voiding contractions.
      Importantly, due to the differences in micturition control between rodents and
      humans, cystometric measurements in these animals have only limited translational
      value. Nevertheless, they are quite instrumental in the study of bladder
      pathophysiology and pharmacology in experimental pre-clinical settings. Recent
      research using this technique has revealed the key role of novel molecular
      players in the mechano- and chemo-sensory properties of the bladder.
FAU - Uvin, Pieter
AU  - Uvin P
AD  - Laboratory of Experimental Urology, Department of Development and Regeneration,
      KU Leuven, Belgium.
FAU - Everaerts, Wouter
AU  - Everaerts W
FAU - Pinto, Silvia
AU  - Pinto S
FAU - Alpizar, Yeranddy A
AU  - Alpizar YA
FAU - Boudes, Mathieu
AU  - Boudes M
FAU - Gevaert, Thomas
AU  - Gevaert T
FAU - Voets, Thomas
AU  - Voets T
FAU - Nilius, Bernd
AU  - Nilius B
FAU - Talavera, Karel
AU  - Talavera K
FAU - De Ridder, Dirk
AU  - De Ridder D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Video-Audio Media
DEP - 20120821
PL  - United States
TA  - J Vis Exp
JT  - Journal of visualized experiments : JoVE
JID - 101313252
SB  - IM
MH  - Animals
MH  - Female
MH  - Mice
MH  - Rats
MH  - Stimulation, Chemical
MH  - Urinary Bladder/*drug effects/*physiology
MH  - Urinary Catheterization/methods
MH  - Urodynamics
PMC - PMC3486752
EDAT- 2012/08/30 06:00
MHDA- 2013/01/26 06:00
CRDT- 2012/08/30 06:00
PHST- 2012/08/30 06:00 [entrez]
PHST- 2012/08/30 06:00 [pubmed]
PHST- 2013/01/26 06:00 [medline]
AID - 3869 [pii]
AID - 10.3791/3869 [doi]
PST - epublish
SO  - J Vis Exp. 2012 Aug 21;(66):e3869. doi: 10.3791/3869.


PMID- 22929009
OWN - NLM
STAT- MEDLINE
DCOM- 20121224
LR  - 20220330
IS  - 1526-3231 (Electronic)
IS  - 0749-8063 (Linking)
VI  - 28
IP  - 10
DP  - 2012 Oct
TI  - Arthroscopic suture fixation for avulsion fractures in the tibial attachment of
      the posterior cruciate ligament.
PG  - 1454-63
LID - 10.1016/j.arthro.2012.04.141 [doi]
LID - S0749-8063(12)00427-6 [pii]
AB  - PURPOSE: The purpose of the study was to highlight our surgical technique of
      arthroscopic suture fixation for acute tibial eminence posterior cruciate
      ligament (PCL) avulsion fractures, clinical and radiographic outcomes, and
      complication rates. METHODS: This prospective study enrolled patients who had
      undergone arthroscopic reduction and suture fixation by use of 4 No. 5 Ethibond
      sutures (Ethicon, Somerville, NJ) for image-proven displaced PCL attachment
      fractures of the tibial eminence with posterior knee instability of grade II or
      higher. The mean follow-up period was 36 months (range, 24 to 45 months).
      Follow-up assessment included 3 different functional scores, KT-1000 arthrometry 
      (MEDmetric, San Diego, CA), and radiographic evaluation. RESULTS: The mean
      preoperative Lysholm score in the 36 patients was 35 (range, 26 to 55); the mean 
      postoperative Lysholm score was 95 (range, 80 to 100). The mean preinjury and
      preoperative Tegner scores in the 36 patients were 7.4 +/- 1.6 (range, 5 to 9)
      and 3.2 +/- 1.5 (range, 2 to 5), respectively. The mean postoperative Tegner
      score was 7.0 +/- 1.8 (range, 5 to 9). At the final follow-up, the International 
      Knee Documentation Committee scores were observed to be normal (grade A) or
      nearly normal (grade B) in 33 patients (91.7%) and abnormal (grade C) in 3
      patients (8.3%). All 36 fractures achieved union within 3 months. No significant 
      complications such as arthrofibrosis, loss of initial fixation, or wound
      infection were noted. CONCLUSIONS: Treatment of tibial PCL avulsion fractures by 
      arthroscopic suture fixation is a successful technique to restore tibial avulsion
      injuries of the PCL with well-documented radiographic healing, good clinical
      outcomes, and low complication rates. LEVEL OF EVIDENCE: Level IV, therapeutic
      case series.
CI  - Copyright (c) 2012 Arthroscopy Association of North America. Published by
      Elsevier Inc. All rights reserved.
FAU - Chen, Szu-Yuan
AU  - Chen SY
AD  - Department of Orthopaedic Surgery, Division of Sports Medicine, Chang Gung
      Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan.
FAU - Cheng, Chun-Ying
AU  - Cheng CY
FAU - Chang, Shih-Sheng
AU  - Chang SS
FAU - Tsai, Min-Chain
AU  - Tsai MC
FAU - Chiu, Chih-Hao
AU  - Chiu CH
FAU - Chen, Alvin Chao-Yu
AU  - Chen AC
FAU - Chan, Yi-Sheng
AU  - Chan YS
LA  - eng
PT  - Journal Article
DEP - 20120825
PL  - United States
TA  - Arthroscopy
JT  - Arthroscopy : the journal of arthroscopic & related surgery : official
      publication of the Arthroscopy Association of North America and the International
      Arthroscopy Association
JID - 8506498
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Arthroscopy
MH  - Female
MH  - Humans
MH  - Knee Injuries/*surgery
MH  - Male
MH  - Middle Aged
MH  - Posterior Cruciate Ligament/*injuries/*surgery
MH  - Prospective Studies
MH  - Suture Techniques
MH  - Tibia/injuries/*surgery
MH  - Tibial Fractures/*surgery
MH  - Young Adult
EDAT- 2012/08/30 06:00
MHDA- 2012/12/25 06:00
CRDT- 2012/08/30 06:00
PHST- 2011/11/30 00:00 [received]
PHST- 2012/04/11 00:00 [revised]
PHST- 2012/04/12 00:00 [accepted]
PHST- 2012/08/30 06:00 [entrez]
PHST- 2012/08/30 06:00 [pubmed]
PHST- 2012/12/25 06:00 [medline]
AID - S0749-8063(12)00427-6 [pii]
AID - 10.1016/j.arthro.2012.04.141 [doi]
PST - ppublish
SO  - Arthroscopy. 2012 Oct;28(10):1454-63. doi: 10.1016/j.arthro.2012.04.141. Epub
      2012 Aug 25.


PMID- 22928982
OWN - NLM
STAT- MEDLINE
DCOM- 20131209
LR  - 20130121
IS  - 1447-0349 (Electronic)
IS  - 1445-8330 (Linking)
VI  - 22
IP  - 1
DP  - 2013 Feb
TI  - 'That was helpful ... no one has talked to me about that before': Research
      participation as a therapeutic activity.
PG  - 76-84
LID - 10.1111/j.1447-0349.2012.00842.x [doi]
AB  - There is considerable interest in the various ethical problems associated with
      undertaking health and social science research. Participants in such research are
      often considered vulnerable because of their health status, social position, or
      dependence on others for health and welfare services. Researchers and ethics
      committees pay scrupulous attention to the identification and amelioration of
      risks to participants. Rarely are the benefits to participants of engaging in
      research highlighted or drawn to the attention of potential participants. Such
      potential benefits need to be considered by researchers and reviewers when
      considering the balance of benefits and harms associated with research projects. 
      In this paper, we particularly consider the psychotherapeutic benefits of
      participation in research.
CI  - (c) 2012 The Authors; International Journal of Mental Health Nursing (c) 2012
      Australian College of Mental Health Nurses Inc.
FAU - Lakeman, Richard
AU  - Lakeman R
AD  - School of Health and Human Sciences, Southern Cross University, Lismore, New
      South Wales, Australia. richard.lakeman@scu.edu.au
FAU - McAndrew, Sue
AU  - McAndrew S
FAU - MacGabhann, Liam
AU  - MacGabhann L
FAU - Warne, Tony
AU  - Warne T
LA  - eng
PT  - Journal Article
DEP - 20120829
PL  - Australia
TA  - Int J Ment Health Nurs
JT  - International journal of mental health nursing
JID - 101140527
MH  - Clinical Nursing Research/*ethics
MH  - *Ethics, Nursing
MH  - Helping Behavior
MH  - Humans
MH  - Motivation
MH  - Narrative Therapy/ethics
MH  - Patient Acceptance of Health Care/psychology
MH  - Patient Education as Topic/*ethics
MH  - Patient Participation/psychology
MH  - Psychotherapy/*ethics
MH  - *Qualitative Research
MH  - Research Subjects/*psychology
MH  - Risk Assessment/*ethics
EDAT- 2012/08/30 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/08/30 06:00
PHST- 2012/08/30 06:00 [entrez]
PHST- 2012/08/30 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1111/j.1447-0349.2012.00842.x [doi]
PST - ppublish
SO  - Int J Ment Health Nurs. 2013 Feb;22(1):76-84. doi:
      10.1111/j.1447-0349.2012.00842.x. Epub 2012 Aug 29.


PMID- 22928823
OWN - NLM
STAT- MEDLINE
DCOM- 20121231
LR  - 20171116
IS  - 1793-6853 (Electronic)
IS  - 0192-415X (Linking)
VI  - 40
IP  - 5
DP  - 2012
TI  - Traditional Japanese herbal (kampo) medicines and treatment of ocular diseases: a
      review.
PG  - 887-904
LID - 10.1142/S0192415X12500668 [doi]
AB  - Herbal medicines have been used clinically in Eastern Asia, and traditional
      Japanese herbal (Kampo) formulas are approved as ethical drugs. The Kampo
      formulas are mixtures of the crude extracts of several herbs, each of which
      contains multiple components. Numerous investigators have reported that some
      herbal medicines are efficacious for treating several human diseases. We reviewed
      the literature on traditional herbal medicines and treatment of ocular diseases. 
      Oral Orengedoku-to and Kakkon-to inhibit postoperative uveitis in humans. Oral
      Goshajinki-gan improved ocular surface disorders in patients with type 1 diabetes
      mellitus. Oral Hachimijio-gan increased retinal blood flow. Keishi-bukuryo-gan
      Sho might be associated with vitreoretinopathy in patients with type 2 diabetes
      mellitus. Oral Hachimijio-gan and Goshajinki-gan delayed lens opacification in
      rats and mice. Oral Sairei-to, Orengedoku-to, Senkanmeimoku-to, Scutellariae
      radix extract, Gardeniae fructus extract, topical Liguisticum wallichii rhizoma
      extract, and intravenous injection of tetramethylpyrazine, baicalin, baicalein,
      wogonin, and crocetin inhibited some forms of experimental uveitis in rabbits.
      Topical glycyrrhizinate improved allergic conjunctivitis in humans and rats. Oral
      crocetin improved eyestrain in humans. Oral berberine diminished experimental
      uveitis in rats. Baicalein, wogonin, berberine, and berberrubine inhibited in
      vitro expression of several cytokines in cultured retinal pigment epithelial
      cells. Some Kampo formulas are efficacious for treating several ocular diseases
      in humans and animals. Some herbal extracts and their components inhibit some
      forms of experimental uveitis.
FAU - Hayasaka, Seiji
AU  - Hayasaka S
AD  - Hayasaka Eye Clinic, Sakura, Tochigi, Japan.
FAU - Kodama, Tatsuo
AU  - Kodama T
FAU - Ohira, Akihiro
AU  - Ohira A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Singapore
TA  - Am J Chin Med
JT  - The American journal of Chinese medicine
JID - 7901431
RN  - 0 (Drugs, Chinese Herbal)
SB  - IM
MH  - Animals
MH  - Diabetes Complications/drug therapy
MH  - Drugs, Chinese Herbal/pharmacology/*therapeutic use
MH  - Eye/*drug effects
MH  - Eye Diseases/*drug therapy
MH  - Humans
MH  - *Magnoliopsida
MH  - *Medicine, Kampo
MH  - *Phytotherapy
MH  - Plants, Medicinal
MH  - Postoperative Complications/drug therapy
EDAT- 2012/08/30 06:00
MHDA- 2013/01/01 06:00
CRDT- 2012/08/30 06:00
PHST- 2012/08/30 06:00 [entrez]
PHST- 2012/08/30 06:00 [pubmed]
PHST- 2013/01/01 06:00 [medline]
AID - 10.1142/S0192415X12500668 [doi]
PST - ppublish
SO  - Am J Chin Med. 2012;40(5):887-904. doi: 10.1142/S0192415X12500668.


PMID- 22928744
OWN - NLM
STAT- MEDLINE
DCOM- 20130620
LR  - 20220330
IS  - 1471-2288 (Electronic)
IS  - 1471-2288 (Linking)
VI  - 12
DP  - 2012 Aug 28
TI  - Learning from failure--rationale and design for a study about discontinuation of 
      randomized trials (DISCO study).
PG  - 131
LID - 10.1186/1471-2288-12-131 [doi]
AB  - BACKGROUND: Randomized controlled trials (RCTs) may be discontinued because of
      apparent harm, benefit, or futility. Other RCTs are discontinued early because of
      insufficient recruitment. Trial discontinuation has ethical implications, because
      participants consent on the premise of contributing to new medical knowledge,
      Research Ethics Committees (RECs) spend considerable effort reviewing study
      protocols, and limited resources for conducting research are wasted. Currently,
      little is known regarding the frequency and characteristics of discontinued RCTs.
      METHODS/DESIGN: Our aims are, first, to determine the prevalence of RCT
      discontinuation for specific reasons; second, to determine whether the risk of
      RCT discontinuation for specific reasons differs between investigator- and
      industry-initiated RCTs; third, to identify risk factors for RCT discontinuation 
      due to insufficient recruitment; fourth, to determine at what stage RCTs are
      discontinued; and fifth, to examine the publication history of discontinued
      RCTs.We are currently assembling a multicenter cohort of RCTs based on protocols 
      approved between 2000 and 2002/3 by 6 RECs in Switzerland, Germany, and Canada.
      We are extracting data on RCT characteristics and planned recruitment for all
      included protocols. Completion and publication status is determined using
      information from correspondence between investigators and RECs, publications
      identified through literature searches, or by contacting the investigators. We
      will use multivariable regression models to identify risk factors for trial
      discontinuation due to insufficient recruitment. We aim to include over 1000 RCTs
      of which an anticipated 150 will have been discontinued due to insufficient
      recruitment. DISCUSSION: Our study will provide insights into the prevalence and 
      characteristics of RCTs that were discontinued. Effective recruitment strategies 
      and the anticipation of problems are key issues in the planning and evaluation of
      trials by investigators, Clinical Trial Units, RECs and funding agencies.
      Identification and modification of barriers to successful study completion at an 
      early stage could help to reduce the risk of trial discontinuation, save limited 
      resources, and enable RCTs to better meet their ethical requirements.
FAU - Kasenda, Benjamin
AU  - Kasenda B
AD  - Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital 
      Basel, Basel, Switzerland.
FAU - von Elm, Erik B
AU  - von Elm EB
FAU - You, John
AU  - You J
FAU - Blumle, Anette
AU  - Blumle A
FAU - Tomonaga, Yuki
AU  - Tomonaga Y
FAU - Saccilotto, Ramon
AU  - Saccilotto R
FAU - Amstutz, Alain
AU  - Amstutz A
FAU - Bengough, Theresa
AU  - Bengough T
FAU - Meerpohl, Jorg
AU  - Meerpohl J
FAU - Stegert, Mihaela
AU  - Stegert M
FAU - Tikkinen, Kari A O
AU  - Tikkinen KA
FAU - Neumann, Ignacio
AU  - Neumann I
FAU - Carrasco-Labra, Alonso
AU  - Carrasco-Labra A
FAU - Faulhaber, Markus
AU  - Faulhaber M
FAU - Mulla, Sohail
AU  - Mulla S
FAU - Mertz, Dominik
AU  - Mertz D
FAU - Akl, Elie A
AU  - Akl EA
FAU - Bassler, Dirk
AU  - Bassler D
FAU - Busse, Jason W
AU  - Busse JW
FAU - Ferreira-Gonzalez, Ignacio
AU  - Ferreira-Gonzalez I
FAU - Lamontagne, Francois
AU  - Lamontagne F
FAU - Nordmann, Alain
AU  - Nordmann A
FAU - Rosenthal, Rachel
AU  - Rosenthal R
FAU - Schandelmaier, Stefan
AU  - Schandelmaier S
FAU - Sun, Xin
AU  - Sun X
FAU - Vandvik, Per O
AU  - Vandvik PO
FAU - Johnston, Bradley C
AU  - Johnston BC
FAU - Walter, Martin A
AU  - Walter MA
FAU - Burnand, Bernard
AU  - Burnand B
FAU - Schwenkglenks, Matthias
AU  - Schwenkglenks M
FAU - Bucher, Heiner C
AU  - Bucher HC
FAU - Guyatt, Gordon H
AU  - Guyatt GH
FAU - Briel, Matthias
AU  - Briel M
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120828
PL  - England
TA  - BMC Med Res Methodol
JT  - BMC medical research methodology
JID - 100968545
SB  - IM
MH  - Ethics Committees, Research
MH  - Humans
MH  - Informed Consent
MH  - Patient Selection
MH  - *Randomized Controlled Trials as Topic
MH  - *Research Design
MH  - Risk Factors
MH  - *Treatment Failure
PMC - PMC3528626
EDAT- 2012/08/30 06:00
MHDA- 2013/06/21 06:00
CRDT- 2012/08/30 06:00
PHST- 2012/07/23 00:00 [received]
PHST- 2012/08/01 00:00 [accepted]
PHST- 2012/08/30 06:00 [entrez]
PHST- 2012/08/30 06:00 [pubmed]
PHST- 2013/06/21 06:00 [medline]
AID - 1471-2288-12-131 [pii]
AID - 10.1186/1471-2288-12-131 [doi]
PST - epublish
SO  - BMC Med Res Methodol. 2012 Aug 28;12:131. doi: 10.1186/1471-2288-12-131.


PMID- 22928452
OWN - NLM
STAT- MEDLINE
DCOM- 20120912
LR  - 20180324
IS  - 0305-5000 (Print)
IS  - 0305-5000 (Linking)
VI  - 39
IP  - 6
DP  - 2012 Jul-Aug
TI  - Ethical marketing in 'aesthetic' ('esthetic') or 'cosmetic dentistry' part 2.
PG  - 390-2, 394-6, 398-400 passim
AB  - UNLABELLED: This is the second article in a series of three. It is essential to
      find out from patients what it is that they hope to achieve when requesting an
      improvement in their dental appearance. Their expectations, hopes and fears need 
      to be explored in detail. The long-term biologic costs of some invasive
      procedures need to be explained to patients in advance so that they can make
      properly informed decisions. Failure to do so renders the practitioner vulnerable
      to a charge of behaving unethically. The differences between ethical marketing
      and selling are explained including the historic development of marketing.
      CLINICAL RELEVANCE: A practical approach, using a modification of the Edward de
      Bono Six Thinking Hats model is described to help ethical practitioners to
      develop sound treatment plans when dealing with complex aesthetic problems.
FAU - Kelleher, Martin G D
AU  - Kelleher MG
AD  - King's College Hospital, London SE5 9RS.
FAU - Djemal, Serpil
AU  - Djemal S
FAU - Lewis, Nicholas
AU  - Lewis N
LA  - eng
PT  - Journal Article
PL  - England
TA  - Dent Update
JT  - Dental update
JID - 7805969
CIN - Dent Update. 2012 Oct;39(8):588-9. PMID: 23167210
CIN - Dent Update. 2012 Oct;39(8):589. PMID: 23167211
MH  - Dentist-Patient Relations
MH  - *Esthetics, Dental
MH  - Ethics, Business
MH  - *Ethics, Dental
MH  - Humans
MH  - Marketing of Health Services/*ethics/legislation & jurisprudence
MH  - Practice Management, Dental/*ethics
EDAT- 2012/08/30 06:00
MHDA- 2012/09/13 06:00
CRDT- 2012/08/30 06:00
PHST- 2012/08/30 06:00 [entrez]
PHST- 2012/08/30 06:00 [pubmed]
PHST- 2012/09/13 06:00 [medline]
AID - 10.12968/denu.2012.39.6.390 [doi]
PST - ppublish
SO  - Dent Update. 2012 Jul-Aug;39(6):390-2, 394-6, 398-400 passim. doi:
      10.12968/denu.2012.39.6.390.


PMID- 22928282
OWN - NLM
STAT- MEDLINE
DCOM- 20120919
LR  - 20190923
IS  - 1547-1896 (Print)
IS  - 0893-7400 (Linking)
VI  - 25
IP  - 8
DP  - 2012 Aug
TI  - On taking down a colleague: is there an ethical mandate to report?
PG  - 63-4
FAU - Anderson, Jim
AU  - Anderson J
AD  - Department of Anesthesiology and Pain Medicine, University of Washington School
      of Medicine, Seattle, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - JAAPA
JT  - JAAPA : official journal of the American Academy of Physician Assistants
JID - 9513102
MH  - Humans
MH  - Interpersonal Relations
MH  - Mandatory Reporting/*ethics
MH  - Physician Assistants/*ethics
MH  - Physician Impairment/legislation & jurisprudence
EDAT- 2012/08/30 06:00
MHDA- 2012/09/20 06:00
CRDT- 2012/08/30 06:00
PHST- 2012/08/30 06:00 [entrez]
PHST- 2012/08/30 06:00 [pubmed]
PHST- 2012/09/20 06:00 [medline]
AID - 10.1097/01720610-201208000-00015 [doi]
PST - ppublish
SO  - JAAPA. 2012 Aug;25(8):63-4. doi: 10.1097/01720610-201208000-00015.


PMID- 22928174
OWN - NLM
STAT- MEDLINE
DCOM- 20130128
LR  - 20141120
IS  - 1539-3704 (Electronic)
IS  - 0003-4819 (Linking)
VI  - 157
IP  - 10
DP  - 2012 Nov 20
TI  - Ethics of commercial screening tests.
PG  - 747-8
FAU - Wallace, Erik A
AU  - Wallace EA
AD  - Department of Internal Medicine, University of Oklahoma School of Community
      Medicine, 4502 East 41st Street, Tulsa, OK 74135, USA. erik-wallace@ouhsc.edu
FAU - Schumann, John H
AU  - Schumann JH
FAU - Weinberger, Steven E
AU  - Weinberger SE
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Intern Med
JT  - Annals of internal medicine
JID - 0372351
SB  - IM
CIN - Ann Intern Med. 2013 Mar 19;158(6):499-500. PMID: 23552212
CIN - Ann Intern Med. 2013 Mar 19;158(6):500. PMID: 23552298
MH  - Consumer Behavior
MH  - Humans
MH  - Marketing/*ethics
MH  - Mass Screening/*economics/*ethics
MH  - Personal Autonomy
MH  - Technology Transfer
EDAT- 2012/08/29 06:00
MHDA- 2013/01/29 06:00
CRDT- 2012/08/29 06:00
PHST- 2012/08/29 06:00 [entrez]
PHST- 2012/08/29 06:00 [pubmed]
PHST- 2013/01/29 06:00 [medline]
AID - 1355172 [pii]
AID - 10.7326/0003-4819-157-10-201211200-00536 [doi]
PST - ppublish
SO  - Ann Intern Med. 2012 Nov 20;157(10):747-8. doi:
      10.7326/0003-4819-157-10-201211200-00536.


PMID- 22927408
OWN - NLM
STAT- MEDLINE
DCOM- 20121210
LR  - 20211021
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 109
IP  - 38
DP  - 2012 Sep 18
TI  - Signing at the beginning makes ethics salient and decreases dishonest
      self-reports in comparison to signing at the end.
PG  - 15197-200
AB  - Many written forms required by businesses and governments rely on honest
      reporting. Proof of honest intent is typically provided through signature at the 
      end of, e.g., tax returns or insurance policy forms. Still, people sometimes
      cheat to advance their financial self-interests-at great costs to society. We
      test an easy-to-implement method to discourage dishonesty: signing at the
      beginning rather than at the end of a self-report, thereby reversing the order of
      the current practice. Using laboratory and field experiments, we find that
      signing before-rather than after-the opportunity to cheat makes ethics salient
      when they are needed most and significantly reduces dishonesty.
FAU - Shu, Lisa L
AU  - Shu LL
AD  - Kellogg School of Management, Northwestern University, Evanston, IL 60208, USA.
FAU - Mazar, Nina
AU  - Mazar N
FAU - Gino, Francesca
AU  - Gino F
FAU - Ariely, Dan
AU  - Ariely D
FAU - Bazerman, Max H
AU  - Bazerman MH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Retracted Publication
DEP - 20120827
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
SB  - IM
RIN - Proc Natl Acad Sci U S A. 2021 Sep 21;118(38):. PMID: 34518237
MH  - Adult
MH  - Behavior
MH  - Commerce
MH  - Deception
MH  - *Ethics
MH  - Female
MH  - *Fraud
MH  - Humans
MH  - Male
MH  - Motivation
MH  - Public Policy
MH  - Self Report
MH  - Young Adult
PMC - PMC3458378
EDAT- 2012/08/29 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/08/29 06:00
PHST- 2012/08/29 06:00 [entrez]
PHST- 2012/08/29 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - 1209746109 [pii]
AID - 10.1073/pnas.1209746109 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15197-200. doi:
      10.1073/pnas.1209746109. Epub 2012 Aug 27.


PMID- 22927189
OWN - NLM
STAT- MEDLINE
DCOM- 20121109
LR  - 20200930
IS  - 1552-4833 (Electronic)
IS  - 1552-4825 (Linking)
VI  - 158A
IP  - 9
DP  - 2012 Sep
TI  - New technologies pave way for fetal personalized medicine: fetal genomic
      sequencing holds promise but heightens ethical concerns.
PG  - vii-viii
LID - 10.1002/ajmg.a.35645 [doi]
LA  - eng
PT  - News
PL  - United States
TA  - Am J Med Genet A
JT  - American journal of medical genetics. Part A
JID - 101235741
SB  - IM
MH  - *Ethics
MH  - Fetal Diseases/*diagnosis/therapy
MH  - Humans
MH  - *Precision Medicine
MH  - *Sequence Analysis, DNA
EDAT- 2012/08/29 06:00
MHDA- 2012/11/10 06:00
CRDT- 2012/08/29 06:00
PHST- 2012/08/29 06:00 [entrez]
PHST- 2012/08/29 06:00 [pubmed]
PHST- 2012/11/10 06:00 [medline]
AID - 10.1002/ajmg.a.35645 [doi]
PST - ppublish
SO  - Am J Med Genet A. 2012 Sep;158A(9):vii-viii. doi: 10.1002/ajmg.a.35645.


PMID- 22926467
OWN - NLM
STAT- MEDLINE
DCOM- 20130429
LR  - 20211021
IS  - 1698-6946 (Electronic)
IS  - 1698-4447 (Linking)
VI  - 17
IP  - 6
DP  - 2012 Nov 1
TI  - Mesenchymal dental stem cells in regenerative dentistry.
PG  - e1062-7
AB  - In the last decade, tissue engineering is a field that has been suffering an
      enormous expansion in the regenerative medicine and dentistry. The use of cells
      as mesenchymal dental stem cells of easy access for dentist and oral surgeon,
      immunosuppressive properties, high proliferation and capacity to differentiate
      into odontoblasts, cementoblasts, osteoblasts and other cells implicated in the
      teeth, suppose a good perspective of future in the clinical dentistry. However,
      is necessary advance in the known of growth factors and signalling molecules
      implicated in tooth development and regeneration of different structures of
      teeth. Furthermore, these cells need a fabulous scaffold that facility their
      integration, differentiation, matrix synthesis and promote multiple specific
      interactions between cells. In this review, we give a brief description of tooth 
      development and anatomy, definition and classification of stem cells, with
      special attention of mesenchymal stem cells, commonly used in the cellular
      therapy for their trasdifferentiation ability, non ethical problems and
      acceptable results in preliminary clinical trials. In terms of tissue
      engineering, we provide an overview of different types of mesenchymal stem cells 
      that have been isolated from teeth, including dental pulp stem cells (DPSCs),
      stem cells from human exfoliated deciduous teeth (SHEDs), periodontal ligament
      stem cells (PDLSCs), dental follicle progenitor stem cells (DFPCs), and stem
      cells from apical papilla (SCAPs), growth factors implicated in regeneration
      teeth and types of scaffolds for dental tissue regeneration.
FAU - Rodriguez-Lozano, Francisco-Javier
AU  - Rodriguez-Lozano FJ
AD  - Servicio de Hematologia y Hemoterapia, Unidad de Trasplante Hematopoyetico y
      Terapia Celular, Hospital Universitario Virgen de Arrixaca, Ctra.
      Madrid-Cartagena, El Palmar 3, 0120 Murcia, Spain. fcojavier@um.es
FAU - Insausti, Carmen-Luisa
AU  - Insausti CL
FAU - Iniesta, Francisca
AU  - Iniesta F
FAU - Blanquer, Miguel
AU  - Blanquer M
FAU - Ramirez, Maria-del-Carmen
AU  - Ramirez MD
FAU - Meseguer, Luis
AU  - Meseguer L
FAU - Meseguer-Henarejos, Ana-Belen
AU  - Meseguer-Henarejos AB
FAU - Marin, Noemi
AU  - Marin N
FAU - Martinez, Salvador
AU  - Martinez S
FAU - Moraleda, Jose-Maria
AU  - Moraleda JM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20121101
PL  - Spain
TA  - Med Oral Patol Oral Cir Bucal
JT  - Medicina oral, patologia oral y cirugia bucal
JID - 101231694
SB  - IM
MH  - Dentistry/*methods
MH  - Humans
MH  - *Mesenchymal Stem Cells
MH  - Regenerative Medicine/*methods
MH  - Tissue Engineering/*methods
MH  - Tooth/*cytology
PMC - PMC3505703
EDAT- 2012/08/29 06:00
MHDA- 2013/04/30 06:00
CRDT- 2012/08/29 06:00
PHST- 2011/08/31 00:00 [received]
PHST- 2012/03/31 00:00 [accepted]
PHST- 2012/08/29 06:00 [entrez]
PHST- 2012/08/29 06:00 [pubmed]
PHST- 2013/04/30 06:00 [medline]
AID - 17925 [pii]
AID - 10.4317/medoral.17925 [doi]
PST - epublish
SO  - Med Oral Patol Oral Cir Bucal. 2012 Nov 1;17(6):e1062-7. doi:
      10.4317/medoral.17925.


PMID- 22926427
OWN - NLM
STAT- MEDLINE
DCOM- 20131112
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 18
IP  - 3
DP  - 2012 Sep
TI  - What if? The farther shores of neuroethics: commentary on "Neuroscience may
      supersede ethics and law".
PG  - 439-46
LID - 10.1007/s11948-012-9391-6 [doi]
AB  - Neuroscience is clearly making enormous progress toward understanding how human
      brains work. The implications of this progress for ethics, law, society, and
      culture are much less clear. Some have argued that neuroscience will lead to vast
      changes, superseding much of law and ethics. The likely limits to the explanatory
      power of neuroscience argue against that position, as do the limits to the social
      relevance of what neuroscience will be able to explain. At the same time
      neuroscience is likely to change societies through increasing their abilities to 
      predict future behavior, to infer subjective mental states by observing physical 
      brain states ("read minds"), to provide evidence in some cases relevant to
      criminal responsibility, to provide new ways to intervene to "treat antisocial
      brains," and to enhance healthy brains. Neuroscience should make important
      cultural changes in our special, and specially negative, views of "mental" versus
      "physical" illness by showing that mental illness is a dysfunction of a physical 
      organ. It will not likely change our beliefs, implicit or explicit, in free will,
      or spark a new conflict between science and religion akin to the creationism
      controversy.
FAU - Greely, Henry T
AU  - Greely HT
AD  - Stanford Law School, 559 Nathan Abbott Way, Stanford, CA 94302-8610, USA.
      hgreely@stanford.edu
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20120825
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
CON - Sci Eng Ethics. 2012 Sep;18(3):433-7. PMID: 22382922
MH  - *Brain
MH  - *Criminal Law
MH  - Humans
MH  - *Morals
MH  - Neurosciences/*ethics
MH  - *Personal Autonomy
MH  - Psychophysiology/*ethics
MH  - Science/*ethics
EDAT- 2012/08/29 06:00
MHDA- 2013/11/13 06:00
CRDT- 2012/08/29 06:00
PHST- 2011/08/29 00:00 [received]
PHST- 2012/08/02 00:00 [accepted]
PHST- 2012/08/29 06:00 [entrez]
PHST- 2012/08/29 06:00 [pubmed]
PHST- 2013/11/13 06:00 [medline]
AID - 10.1007/s11948-012-9391-6 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2012 Sep;18(3):439-46. doi: 10.1007/s11948-012-9391-6. Epub 2012 
      Aug 25.


PMID- 22926408
OWN - NLM
STAT- MEDLINE
DCOM- 20130102
LR  - 20131121
IS  - 1878-1632 (Electronic)
IS  - 1529-9430 (Linking)
VI  - 12
IP  - 8
DP  - 2012 Aug
TI  - Epidural fentanyl for postoperative analgesia after lumbar canal decompression: a
      randomized controlled trial.
PG  - 646-51
LID - 10.1016/j.spinee.2012.07.007 [doi]
LID - S1529-9430(12)00449-4 [pii]
AB  - BACKGROUND CONTEXT: Postoperative back pain is common after decompression surgery
      for lumbar stenosis and often delays discharge from hospital. Achieving regional 
      analgesia by intraoperative delivery of epidural opiates after lumbar canal
      decompression is a promising approach to reduce postoperative pain and enhance
      early mobilization. However, there have been concerns about opiate-related
      complications, such as respiratory depression and urinary retention in what is
      generally an elderly population of patients. PURPOSE: To assess the analgesic
      efficacy of bolus epidural fentanyl administered intraoperatively after lumbar
      decompression for degenerative canal stenosis. STUDY DESIGN/SETTING:
      Patient-blinded randomized controlled trial conducted at two university
      neurosurgical centers. PATIENT SAMPLE: Adults (older than 18 years) with
      neurogenic claudication and/or lower limb radiculopathy and concordant lumbar
      spinal canal stenosis demonstrated on magnetic resonance imaging. Patients with
      previous lumbar spinal surgery, a contraindication to fentanyl, or requiring
      instrumentation were excluded. OUTCOME MEASURES: The primary outcome measure was 
      patient-reported Visual Analogue Score (VAS) for pain recorded preoperatively, in
      recovery, and on the first and second postoperative days if the patient remained 
      in the hospital. Secondary outcomes were duration of surgery, length of stay, and
      any side effects or complications. METHODS: Patients underwent a one to three
      level lumbar canal decompression as required, via a midline incision, under
      general anesthesia. Before wound closure either no drug (control) or a 100-mug
      bolus of fentanyl was administered via an epidural catheter inserted 10 cm
      rostral to the operated level. Patients were blinded to group allocation, and
      analysis was by intention to treat. The trial was approved by the National Health
      Service Research Ethics Service and the Medicines and Healthcare products
      Regulatory Agency. No commercial or other source of funding was received.
      RESULTS: Sixty patients were randomized, 29 to fentanyl and 31 to control.
      Demographics, duration of surgery, and preoperative VAS were not significantly
      different between the groups. VAS in recovery was significantly lower in patients
      treated with fentanyl (mean [standard deviation]: 2.6 [2.7] vs. 4.7 [2.4];
      p=.003). Later VAS and postoperative length of stay were similar between groups. 
      More patients in the fentanyl group required temporary urinary catheterization,
      but there was no significant difference in the incidence of side effects.
      CONCLUSIONS: Bolus epidural fentanyl provides effective short-term postoperative 
      analgesia after lumbar canal decompression and may be a useful adjunct to pain
      management in patients undergoing lumbar spine surgery.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Guilfoyle, Mathew R
AU  - Guilfoyle MR
AD  - Department of Neurosurgery, Addenbrooke's Hospital, Hills Rd., Cambridge, UK.
FAU - Mannion, Richard J
AU  - Mannion RJ
FAU - Mitchell, Patrick
AU  - Mitchell P
FAU - Thomson, Simon
AU  - Thomson S
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
DEP - 20120825
PL  - United States
TA  - Spine J
JT  - The spine journal : official journal of the North American Spine Society
JID - 101130732
RN  - 0 (Analgesics, Opioid)
RN  - UF599785JZ (Fentanyl)
SB  - IM
CIN - Spine J. 2012 Aug;12(8):652-5. PMID: 23021028
MH  - Aged
MH  - Analgesics, Opioid/*administration & dosage
MH  - Anesthesia, Epidural
MH  - Decompression, Surgical
MH  - Female
MH  - Fentanyl/*administration & dosage
MH  - Humans
MH  - Injections, Epidural
MH  - Intraoperative Care
MH  - *Laminectomy
MH  - Low Back Pain/drug therapy/etiology
MH  - *Lumbar Vertebrae
MH  - Male
MH  - Middle Aged
MH  - Pain, Postoperative/*drug therapy
MH  - Spinal Stenosis/*surgery
EDAT- 2012/08/29 06:00
MHDA- 2013/01/03 06:00
CRDT- 2012/08/29 06:00
PHST- 2011/11/25 00:00 [received]
PHST- 2012/04/18 00:00 [revised]
PHST- 2012/07/06 00:00 [accepted]
PHST- 2012/08/29 06:00 [entrez]
PHST- 2012/08/29 06:00 [pubmed]
PHST- 2013/01/03 06:00 [medline]
AID - S1529-9430(12)00449-4 [pii]
AID - 10.1016/j.spinee.2012.07.007 [doi]
PST - ppublish
SO  - Spine J. 2012 Aug;12(8):646-51. doi: 10.1016/j.spinee.2012.07.007. Epub 2012 Aug 
      25.


PMID- 22926196
OWN - NLM
STAT- MEDLINE
DCOM- 20130327
LR  - 20151119
IS  - 1096-7206 (Electronic)
IS  - 1096-7192 (Linking)
VI  - 107
IP  - 3
DP  - 2012 Nov
TI  - Experiences of parents and patients with the timing of Mucopolysaccharidosis type
      I (MPS I) diagnoses and its relevance to the ethical debate on newborn screening.
PG  - 501-7
LID - 10.1016/j.ymgme.2012.08.008 [doi]
LID - S1096-7192(12)00308-3 [pii]
AB  - INTRODUCTION: Newborn screening (NBS) techniques have been developed for several 
      lysosomal storage disorders (LSDs), including Mucopolysaccharidosis type I (MPS
      I). MPS I is an LSD with a wide phenotypic spectrum that ranges from the severe
      Hurler phenotype to the attenuated Scheie phenotype. To improve the ethical
      discussion about NBS for MPS I, we performed an interview study to explore the
      experiences of MPS I patients and their parents with the timings of their
      diagnoses. METHODS: We used a qualitative research approach consisting of 17
      interviews with the parents of patients with all MPS I phenotypes and with
      patients with attenuated forms of MPS I. The interviews were audio-recorded,
      transcribed and subsequently analyzed to identify the main themes identified by
      the participants. RESULTS: Five important themes, focusing on the experienced
      disadvantages of delayed diagnosis and the advantages and disadvantages of a
      hypothetical earlier diagnosis, were identified in our group of participants: 1) 
      delayed diagnosis causing parental frustration, 2) delayed diagnosis causing
      patient frustration, 3) early diagnosis enabling reproductive decision-making, 4)
      early diagnosis enabling focusing on the diagnosis, and 5) early diagnosis
      enabling timely initiation of treatment. There was a remarkable similarity in the
      experiences with timing of diagnosis between parents of patients with the severe 
      and the attenuated forms. CONCLUSION: This was the first study to explore the
      personal experiences of MPS I patients and their parents with diagnostic timing. 
      Our study identified five important themes that are highly relevant to the
      ethical discussion on expanding NBS programs for MPS I.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - de Ru, Minke H
AU  - de Ru MH
AD  - Department of Pediatrics, Academic Medical Center, University Hospital of
      Amsterdam, Amsterdam, The Netherlands.
FAU - Bouwman, Machtelt G
AU  - Bouwman MG
FAU - Wijburg, Frits A
AU  - Wijburg FA
FAU - van Zwieten, Myra C B
AU  - van Zwieten MC
LA  - eng
PT  - Journal Article
DEP - 20120816
PL  - United States
TA  - Mol Genet Metab
JT  - Molecular genetics and metabolism
JID - 9805456
SB  - IM
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Delayed Diagnosis
MH  - Early Diagnosis
MH  - Female
MH  - Genetic Counseling/ethics/psychology
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Mucopolysaccharidosis I/*diagnosis/pathology/*psychology
MH  - Neonatal Screening/*ethics/organization & administration/psychology
MH  - Parents/*psychology
MH  - Phenotype
MH  - Severity of Illness Index
MH  - Surveys and Questionnaires
MH  - Time Factors
EDAT- 2012/08/29 06:00
MHDA- 2013/03/28 06:00
CRDT- 2012/08/29 06:00
PHST- 2012/07/02 00:00 [received]
PHST- 2012/08/06 00:00 [revised]
PHST- 2012/08/06 00:00 [accepted]
PHST- 2012/08/29 06:00 [entrez]
PHST- 2012/08/29 06:00 [pubmed]
PHST- 2013/03/28 06:00 [medline]
AID - S1096-7192(12)00308-3 [pii]
AID - 10.1016/j.ymgme.2012.08.008 [doi]
PST - ppublish
SO  - Mol Genet Metab. 2012 Nov;107(3):501-7. doi: 10.1016/j.ymgme.2012.08.008. Epub
      2012 Aug 16.


PMID- 22925949
OWN - NLM
STAT- MEDLINE
DCOM- 20141021
LR  - 20140214
IS  - 1460-2245 (Electronic)
IS  - 0957-4824 (Linking)
VI  - 29
IP  - 1
DP  - 2014 Mar
TI  - Ethics-based decision-making and health impact assessment.
PG  - 98-108
LID - 10.1093/heapro/das040 [doi]
AB  - To compare the use of health impact assessment (HIA) and the decision-making
      triangle (DMT) framework for evidence-informed, ethics-based decision-making and 
      consider implications for practice. We compared HIA and the DMT approach with
      reference to: their use of evidence and theory; their application of ethical
      principles or values; and how they aid decision-making. A good fit between the
      HIA and DMT approaches was found. Ways in which they could be of benefit to each 
      other were identified. The DMT approach and HIA are highly compatible: they are
      rooted in largely shared ethical principles or values; both involve appropriate
      use of evidence and theory; and both are concerned with enhancing the quality of 
      decision-making in the interests of population health. The DMT approach and HIA
      are of potential value to each other: established HIA methods and tools can be of
      practical help in using the DMT approach; and the DMT framework provides insights
      to how HIA methods and processes could be improved and the vision of 'impacts
      that matter' widened.
FAU - Tannahill, Andrew
AU  - Tannahill A
AD  - *Corresponding author. E-mail: margaret.j.douglas@nhslothian.scot.nhs.uk.
FAU - Douglas, Margaret J
AU  - Douglas MJ
LA  - eng
PT  - Journal Article
DEP - 20120827
PL  - England
TA  - Health Promot Int
JT  - Health promotion international
JID - 9008939
SB  - IM
MH  - Decision Making/*ethics
MH  - Evidence-Based Practice
MH  - *Health Impact Assessment/methods
MH  - *Health Promotion
MH  - Humans
MH  - Models, Theoretical
MH  - Social Values
OTO - NOTNLM
OT  - ethics
OT  - evidence
OT  - health impact assessment
OT  - values
EDAT- 2012/08/29 06:00
MHDA- 2014/10/22 06:00
CRDT- 2012/08/29 06:00
PHST- 2012/08/29 06:00 [entrez]
PHST- 2012/08/29 06:00 [pubmed]
PHST- 2014/10/22 06:00 [medline]
AID - das040 [pii]
AID - 10.1093/heapro/das040 [doi]
PST - ppublish
SO  - Health Promot Int. 2014 Mar;29(1):98-108. doi: 10.1093/heapro/das040. Epub 2012
      Aug 27.


PMID- 22925939
OWN - NLM
STAT- MEDLINE
DCOM- 20130319
LR  - 20151119
IS  - 1769-6623 (Electronic)
IS  - 0750-7658 (Linking)
VI  - 31
IP  - 10
DP  - 2012 Oct
TI  - [Changes in kaliemia following rapid sequence induction with succinylcholine in
      critically ill patients].
PG  - 788-92
LID - 10.1016/j.annfar.2012.06.024 [doi]
LID - S0750-7658(12)00260-2 [pii]
AB  - OBJECTIVE: Evaluate the changes in potassium following rapid sequence induction
      with succinylcholine in critically ill-patients and determine whether hospital
      length of stay could influence the succinylcholine-induced hyperkaliemia. STUDY
      DESIGN: Prospective and observational study. PATIENTS AND METHODS: After approval
      by our local ethical committee, we prospectively included 36 patients admitted
      from more than 24hours in ICU and who required succinylcholine for rapid tracheal
      intubation (1mg/kg). Serum potassium was measured before, 5 and 30min after
      succinylcholine. The incidence of life-threatening hyperkaliemia (>/=6.5mmol/L)
      was noted. RESULTS: We could observe significant and transient increase in serum 
      potassium (median increase of 0.45 [0.20-0.80] mmol/L at five minutes). A
      significant relationship was observed between the ICU length of stay and arterial
      potassium increase (r=0.37, P<0.05). From the ROC curve, a threshold of 12 days
      had an 86% sensitivity and 69% specificity in discriminating patients in whom the
      potassium increase was more than 1.5mmol/L. CONCLUSION: Induction with
      succinylcholine is followed by significant but transient hyperkaliema. The ICU
      length of stay before giving succinylcholine could influence significantly the
      amplitude of potassium increase.
CI  - Copyright (c) 2012 Societe francaise d'anesthesie et de reanimation (Sfar).
      Published by Elsevier SAS. All rights reserved.
FAU - Megret, F
AU  - Megret F
AD  - Service d'anesthesie-reanimation II, hopital du Haut-Leveque, CHU de Bordeaux,
      avenue Magellan, 3300 Bordeaux, France.
FAU - Perrier, V
AU  - Perrier V
FAU - Fleureau, C
AU  - Fleureau C
FAU - Germain, A
AU  - Germain A
FAU - Dewitte, A
AU  - Dewitte A
FAU - Roze, H
AU  - Roze H
FAU - Ouattara, A
AU  - Ouattara A
LA  - fre
PT  - Clinical Trial
PT  - English Abstract
PT  - Journal Article
TT  - Variation de kaliemie apres une induction en sequence rapide avec la
      succinylcholine chez les patients de reanimation.
DEP - 20120824
PL  - France
TA  - Ann Fr Anesth Reanim
JT  - Annales francaises d'anesthesie et de reanimation
JID - 8213275
RN  - 0 (Neuromuscular Depolarizing Agents)
RN  - J2R869A8YF (Succinylcholine)
RN  - RWP5GA015D (Potassium)
SB  - IM
MH  - Aged
MH  - *Anesthesia
MH  - Critical Care
MH  - Critical Illness/*therapy
MH  - Female
MH  - Humans
MH  - Hyperkalemia/*chemically induced
MH  - Length of Stay
MH  - Male
MH  - Middle Aged
MH  - Neuromuscular Depolarizing Agents/*adverse effects
MH  - Potassium/*blood
MH  - Prospective Studies
MH  - ROC Curve
MH  - Resuscitation
MH  - Succinylcholine/*adverse effects
EDAT- 2012/08/29 06:00
MHDA- 2013/03/21 06:00
CRDT- 2012/08/29 06:00
PHST- 2011/12/12 00:00 [received]
PHST- 2012/06/18 00:00 [accepted]
PHST- 2012/08/29 06:00 [entrez]
PHST- 2012/08/29 06:00 [pubmed]
PHST- 2013/03/21 06:00 [medline]
AID - S0750-7658(12)00260-2 [pii]
AID - 10.1016/j.annfar.2012.06.024 [doi]
PST - ppublish
SO  - Ann Fr Anesth Reanim. 2012 Oct;31(10):788-92. doi: 10.1016/j.annfar.2012.06.024. 
      Epub 2012 Aug 24.


PMID- 22925526
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20211021
IS  - 1471-2474 (Electronic)
IS  - 1471-2474 (Linking)
VI  - 13
DP  - 2012 Aug 27
TI  - The development of whole blood titanium levels after instrumented spinal fusion -
      is there a correlation between the number of fused segments and titanium levels?
PG  - 159
LID - 10.1186/1471-2474-13-159 [doi]
AB  - BACKGROUND: Most modern spinal implants contain titanium and remain in the
      patient's body permanently. Local and systemic effects such as tissue necrosis,
      osteolysis and malignant cell transformation caused by implants have been
      described. Increasing tissue concentration and whole blood levels of ions are
      necessary before a disease caused by a contaminant develops. The aim of the
      present study was the measurement of whole blood titanium levels and the
      evaluation of a possible correlation between these changes and the number of
      fused segments. METHODS: A prospective study was designed to determine changes in
      whole blood titanium levels after spinal fusion and to analyze the correlation to
      the number of pedicle screws, cross connectors and interbody devices
      implanted.Blood samples were taken preoperatively in group I (n = 15), on the
      first, second and 10th day postoperatively, as well as 3 and 12 months after
      surgery.Group II (n = 16) served as a control group of volunteers who did not
      have any metal implants in the body. Blood samples were taken once in this
      group.The number of screw-rod-connections and the length of the spinal fusion
      were determined using radiographic pictures. This study was checked and approved 
      by the ethical committee of the University of Tuebingen. RESULTS: The mean age in
      group I was 47 +/- 22 years (range 16 - 85 years). There were three male (20%)
      and twelve female (80%) patients. The median number of fused segments was 5
      (range 1 to 11 segments).No statistically significant increase in the titanium
      level was seen 12 months after surgery (mean difference: -7.2 mug/l, 95% CI:
      -26.9 to 12.5 mug/l, p = 0.446). By observing the individual titanium levels, 4
      out of 15 patients demonstrated an increase in titanium levels 12 months after
      surgery.No statistically significant correlation between fused segments (r =
      -0.188, p = 0.503) length of instrumentation (r = -0.329, p = 0.231), number of
      interbody devices (r = -0.202, p = 0.291) and increase of titanium levels over
      the observation period was seen. CONCLUSIONS: Instrumented spinal fusion does not
      lead to a statistically significant increase in whole blood titanium levels.
      There seems to be no correlation between the number of pedicle screws, cross
      connectors and interbody devices implanted and the increase of serum titanium
      levels.
FAU - Ipach, Ingmar
AU  - Ipach I
AD  - Department of Orthopaedic Surgery, University Hospital Tuebingen, Tuebingen,
      Germany. Ingmar.Ipach@med.uni-tuebingen.de
FAU - Schafer, Ralf
AU  - Schafer R
FAU - Mittag, Falk
AU  - Mittag F
FAU - Leichtle, Carmen
AU  - Leichtle C
FAU - Wolf, Petra
AU  - Wolf P
FAU - Kluba, Torsten
AU  - Kluba T
LA  - eng
PT  - Journal Article
DEP - 20120827
PL  - England
TA  - BMC Musculoskelet Disord
JT  - BMC musculoskeletal disorders
JID - 100968565
RN  - 0 (Biomarkers)
RN  - D1JT611TNE (Titanium)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - *Bone Screws
MH  - Case-Control Studies
MH  - Female
MH  - Germany
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Prosthesis Design
MH  - Spinal Fusion/adverse effects/*instrumentation
MH  - Time Factors
MH  - Titanium/*blood
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC3495207
EDAT- 2012/08/29 06:00
MHDA- 2013/03/13 06:00
CRDT- 2012/08/29 06:00
PHST- 2011/12/20 00:00 [received]
PHST- 2012/08/20 00:00 [accepted]
PHST- 2012/08/29 06:00 [entrez]
PHST- 2012/08/29 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
AID - 1471-2474-13-159 [pii]
AID - 10.1186/1471-2474-13-159 [doi]
PST - epublish
SO  - BMC Musculoskelet Disord. 2012 Aug 27;13:159. doi: 10.1186/1471-2474-13-159.


PMID- 22924280
OWN - NLM
STAT- MEDLINE
DCOM- 20120904
LR  - 20151119
IS  - 0014-1755 (Print)
IS  - 0014-1755 (Linking)
VI  - 50
IP  - 2
DP  - 2012 Apr
TI  - Factors associated with adherence to highly active antiretroviral therapy among
      children in two referral hospitals, northwest Ethiopia.
PG  - 115-24
AB  - BACKGROUND: highly active antiretroviral therapy (HAART) results in improved
      survival, clinical, immunological and virological response for children.
      Adherence to HAART is one of the very important factors which determine treatment
      success and occurrence of viral resistance. The need for near perfect adherence
      to lifelong antiretroviral therapy (ART) during childhood is a major challenge in
      the administration of HAART to HIV infected children. OBJECTIVE: the study was
      aimed to determine the level of adherence and factors associated with adherence
      to HAART among children in Felege Hiwot and Gondar University referral hospitals.
      METHODS: institution based cross-sectional study was conducted on 204 children in
      the paediatric ART clinics of Gondar University and Felege Hiwot hospitals.
      Sample size was determined by single population proportion formula and all
      children on ART for > or = 1 month and coming to the clinic during the data
      collection period were studied Ethical clearance was obtained from the
      Institutional Review Board of the University of Gondar. Data were collected by
      four nurses from the caregivers and patient charts using a pretested and
      structured questionnaire after informed consent. Descriptive statistics were
      calculated to describe study population and medical characteristics of
      participants while binary and multiple logistic regression analyses were used to 
      determine the effect of factors on the outcome variable. RESULTS: The study
      included 204 children (123 from Flege Hiwot and 81 from Gondar). One hundred and 
      seven (52.4%) were males and 97(47.6%) were females. Majority (82.4%) of
      caregivers were females. Thirty days optimum (> or = 95%) adherence rate was
      80.9% for children. Adherence counseling before initiation (OR=4.37, 95%CI 1.17 -
      16.37), caregiver formal education, (OR=4.85, 95%CI 1.89 - 12.39) and caregiver's
      ability to identify ARV drug correctly (OR = 8.61, 95%CI 2.59-28.68) were
      positively associated while care giver substance use (OR=0.31, 95%CI 0.10 - 0.93)
      was negatively associated with adherence as compared to their counter parts.
      CONCLUSION: optimum adherence rate to HAART in the study population was lower
      than the recommended Adherence counseling, caregiver education, substance use by 
      caregiver, identification of ARVs determined adherence to HAART of children.
      Adherence assessment and counseling efforts should be continually integrated with
      ART for children and their caregivers.
FAU - Azmeraw, Daniel
AU  - Azmeraw D
AD  - University of Gondar, Gondar Ethiopia.
FAU - Wasie, Belaynew
AU  - Wasie B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ethiopia
TA  - Ethiop Med J
JT  - Ethiopian medical journal
JID - 0373223
SB  - IM
MH  - Adolescent
MH  - Age Distribution
MH  - Antiretroviral Therapy, Highly Active/*methods/psychology
MH  - Caregivers/psychology
MH  - Child
MH  - Child, Preschool
MH  - Counseling
MH  - Cross-Sectional Studies
MH  - Ethiopia
MH  - Female
MH  - HIV Infections/complications/*drug therapy/psychology/virology
MH  - Health Care Surveys
MH  - Health Knowledge, Attitudes, Practice
MH  - Hospitals, Teaching
MH  - Humans
MH  - Infant
MH  - Male
MH  - Medication Adherence/psychology/*statistics & numerical data
MH  - Referral and Consultation
MH  - Sex Distribution
MH  - Social Support
MH  - Socioeconomic Factors
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
EDAT- 2012/08/29 06:00
MHDA- 2012/09/05 06:00
CRDT- 2012/08/29 06:00
PHST- 2012/08/29 06:00 [entrez]
PHST- 2012/08/29 06:00 [pubmed]
PHST- 2012/09/05 06:00 [medline]
PST - ppublish
SO  - Ethiop Med J. 2012 Apr;50(2):115-24.


PMID- 22924244
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20191112
IS  - 1321-2753 (Print)
IS  - 1321-2753 (Linking)
VI  - 30
IP  - 1
DP  - 2012 Mar
TI  - Applying for ethical approval for a national multisite study: the challenges and 
      barriers.
PG  - 103-22
FAU - Kornhaber, Rachel Anne
AU  - Kornhaber RA
AD  - Severe Burns Injury Unit, Royal North Shore Hospital.
      rachel.kornhaber@adelaide.edu.au
FAU - Abu-Qamar, Ma'en Zaid
AU  - Abu-Qamar MZ
FAU - Wilson, Anne
AU  - Wilson A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Monash Bioeth Rev
JT  - Monash bioethics review
JID - 100973394
SB  - IM
MH  - Australia
MH  - Ethics Committees, Research/*organization & administration
MH  - Forms and Records Control
MH  - Humans
MH  - Multicenter Studies as Topic
MH  - Online Systems
MH  - *Qualitative Research
EDAT- 2012/08/29 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/08/29 06:00
PHST- 2012/08/29 06:00 [entrez]
PHST- 2012/08/29 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
AID - 10.1007/BF03351337 [doi]
PST - ppublish
SO  - Monash Bioeth Rev. 2012 Mar;30(1):103-22. doi: 10.1007/BF03351337.


PMID- 22924200
OWN - NLM
STAT- MEDLINE
DCOM- 20121010
LR  - 20191112
IS  - 1145-0762 (Print)
IS  - 1145-0762 (Linking)
VI  - 23
IP  - 2
DP  - 2012 Jun
TI  - Biobanks for research. Ethical and legal aspects in human biological samples
      collections in France.
PG  - 165-72, 183-4
AB  - Because they gather huge quantities of human biological samples and information
      allowing for better understanding of diseases, biobanks appear as a very powerful
      tool for boosting both medical research and public health as a whole. Although
      France does not really appear as a leader in biobanking compared to China or UK, 
      biobanks and other samples collections abound in our country and have then been
      regulated, even though french law does not use the term biobank as such. The
      present article gives an overview of the current legal framework and explores the
      remaining ethical and legal issues, concerning particularly the protection of
      donors, the sharing of biobanks content and the sharing of biobanks benefits. The
      article explains how these universal questions arise in this country and what
      answers (sometimes specific) they get or could get in the following years.
FAU - Noiville, Christine
AU  - Noiville C
AD  - CNRS, Universite Paris 1.
LA  - eng
PT  - Journal Article
PL  - France
TA  - J Int Bioethique
JT  - Journal international de bioethique = International journal of bioethics
JID - 9015754
SB  - IM
MH  - Biological Specimen Banks/*ethics/*legislation & jurisprudence
MH  - Confidentiality/ethics/legislation & jurisprudence
MH  - France
MH  - Humans
MH  - Information Dissemination/ethics/legislation & jurisprudence
MH  - Informed Consent/ethics/legislation & jurisprudence
MH  - Ownership/ethics/legislation & jurisprudence
MH  - *Public Policy
MH  - Tissue Donors/*ethics/*legislation & jurisprudence
EDAT- 2012/08/29 06:00
MHDA- 2012/10/12 06:00
CRDT- 2012/08/29 06:00
PHST- 2012/08/29 06:00 [entrez]
PHST- 2012/08/29 06:00 [pubmed]
PHST- 2012/10/12 06:00 [medline]
AID - 10.3917/jib.232.0165 [doi]
PST - ppublish
SO  - J Int Bioethique. 2012 Jun;23(2):165-72, 183-4. doi: 10.3917/jib.232.0165.


PMID- 22924198
OWN - NLM
STAT- MEDLINE
DCOM- 20121010
LR  - 20191112
IS  - 1145-0762 (Print)
IS  - 1145-0762 (Linking)
VI  - 23
IP  - 2
DP  - 2012 Jun
TI  - The survey of clinical human experimentation research in ethical review of
      postgraduates students.
PG  - 131-9, 181
AB  - An anonymous questionnaire was used to investigate the status quo of ethics
      review of human subject experiments among postgraduate students in clinical
      practice with the main conclusions as follows: Human subject experiments make up 
      a large ratio of clinical research; the construction of an ethics review has been
      initially formulated, but there exists a gap in ethics awareness between advisors
      and the postgraduates with the desperate need to receive ethics review. It is
      necessary to realize the importance of informed consent and to strengthen the
      strict supervision of placebo application.
FAU - Xu, Yifan
AU  - Xu Y
AD  - China Medical University in Reading.
FAU - Zhu, Zheng
AU  - Zhu Z
FAU - Wang, Liyu
AU  - Wang L
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - France
TA  - J Int Bioethique
JT  - Journal international de bioethique = International journal of bioethics
JID - 9015754
SB  - IM
MH  - *Attitude
MH  - Biomedical Research/*ethics
MH  - China
MH  - *Education, Graduate
MH  - *Ethical Review
MH  - Ethics Committees, Research
MH  - Health Care Surveys
MH  - Hospitals, Teaching
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Students
EDAT- 2012/08/29 06:00
MHDA- 2012/10/12 06:00
CRDT- 2012/08/29 06:00
PHST- 2012/08/29 06:00 [entrez]
PHST- 2012/08/29 06:00 [pubmed]
PHST- 2012/10/12 06:00 [medline]
AID - 10.3917/jib.232.0131 [doi]
PST - ppublish
SO  - J Int Bioethique. 2012 Jun;23(2):131-9, 181. doi: 10.3917/jib.232.0131.


PMID- 22924197
OWN - NLM
STAT- MEDLINE
DCOM- 20121010
LR  - 20191112
IS  - 1145-0762 (Print)
IS  - 1145-0762 (Linking)
VI  - 23
IP  - 2
DP  - 2012 Jun
TI  - [The research ethics committees: the French example of the Comites de Protection 
      des Personnes].
PG  - 117-29, 180
AB  - Succeeding to the CCPPRB as created by the statute of December 20, 1988, the CPP 
      are the ethics committees foreseen by international texts dealing with research
      involving human beings. They were ruled by the statute of 9 August 9, 2004 and
      are partly modified by the last statute of March 5, 2012, settling a new
      classification of research, each category under a different set of rules. To
      solve difficulties arising from the number of committees (40), a new National
      Committee for research is created, working closely with the minister. Another
      purpose of the reform was to include the observational research to extend the
      area of research with opened access to international level for publications.
FAU - Duprat, Jean-Pierre
AU  - Duprat JP
AD  - Universite Montesquieu-Bordeaux IV.
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Les comites d'ethique de la recherche: l'exemple francais des comites de
      protection des personnes.
PL  - France
TA  - J Int Bioethique
JT  - Journal international de bioethique = International journal of bioethics
JID - 9015754
SB  - IM
MH  - Ethics Committees, Research/*organization & administration
MH  - France
MH  - Humans
EDAT- 2012/08/29 06:00
MHDA- 2012/10/12 06:00
CRDT- 2012/08/29 06:00
PHST- 2012/08/29 06:00 [entrez]
PHST- 2012/08/29 06:00 [pubmed]
PHST- 2012/10/12 06:00 [medline]
AID - 10.3917/jib.232.0117 [doi]
PST - ppublish
SO  - J Int Bioethique. 2012 Jun;23(2):117-29, 180. doi: 10.3917/jib.232.0117.


PMID- 22924196
OWN - NLM
STAT- MEDLINE
DCOM- 20121010
LR  - 20120828
IS  - 1145-0762 (Print)
IS  - 1145-0762 (Linking)
VI  - 23
IP  - 2
DP  - 2012 Jun
TI  - [Transcultural discussion in bioethics drawn from research experience in China:
      building up a theoretical and methodological framework for further research
      cooperation].
PG  - 105-16, 179-80
AB  - My article discusses bioethics in transcultural context and builds on an
      experience of conducting research in China in partnership with Chinese scholars
      and institutions. Key points are about the creation of ethical committees and
      their prerogatives, the regulation of experimenting in human and animal, and of
      donating and transplanting organs. Ethical issues are approached according to an 
      anthropological reading. Three transversal lines for further research are
      suggested: global/local ethical governance applied to research ethics;
      implications of transnationalizing and delocalizing research practices with
      regards to governance; theoretical positioning--conceptual pluralism versus
      pragmatic pluralism--following actual confrontation to transcultural variations
      in research ethics. Moreover, this work claims for conceptualizing and
      implementing an ethics in context while assessing intangible (non-relative)
      principles based on knowledge production and a global patrimony.
FAU - Micollier, Evelyne
AU  - Micollier E
AD  - IRD, UMI 233, TransVIHMI.
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Reflexion transculturelle en bioethique a partir d'une experience en Chine:
      construire un cadre theorique et methodologique pour de futures cooperations de
      recherche.
PL  - France
TA  - J Int Bioethique
JT  - Journal international de bioethique = International journal of bioethics
JID - 9015754
SB  - IM
MH  - Animal Experimentation/ethics
MH  - China
MH  - Ethics Committees, Research/organization & administration
MH  - *Ethics, Research
MH  - France
MH  - Human Experimentation/ethics
MH  - Humans
MH  - *International Cooperation
MH  - Models, Organizational
MH  - Tissue and Organ Procurement/ethics
EDAT- 2012/08/29 06:00
MHDA- 2012/10/12 06:00
CRDT- 2012/08/29 06:00
PHST- 2012/08/29 06:00 [entrez]
PHST- 2012/08/29 06:00 [pubmed]
PHST- 2012/10/12 06:00 [medline]
PST - ppublish
SO  - J Int Bioethique. 2012 Jun;23(2):105-16, 179-80.


PMID- 22924195
OWN - NLM
STAT- MEDLINE
DCOM- 20121010
LR  - 20191112
IS  - 1145-0762 (Print)
IS  - 1145-0762 (Linking)
VI  - 23
IP  - 2
DP  - 2012 Jun
TI  - [Ethics and medical genetics].
PG  - 95-102, 178-9
AB  - Medical genetics may be distinguished from other medical specialities by its
      family dimension. Genetics raises many questions in the field of ethics
      concerning the potential applications in clinical medicine, in particular because
      of the technological evolution of human genetics in the medical field and the
      genetic research on the charting of the human genome. Human genetics involves
      filiation and questions the foundation of our society and the potential
      standardisation of human beings. The prescription of genetic tests is a tool for 
      doctors but its use should be measured and carefully thought out according to the
      questions asked and the results expected. Examination of this issue within the
      context of the bioethics laws in France has made it possible to establish a
      framework for a certain number of practices so as to answer certain questions in 
      human genetics. This article attempts to review the situation as it stands today 
      with regard to the ethical issues raised by genetic tests, presymptomatic
      diagnosis, prenatal and pre-implantation diagnosis, and bio-collections.
FAU - Lacombe, Didier
AU  - Lacombe D
AD  - Service de genetique Medicale, CHU de Bordeaux, Laboratoire "Maladies rares:
      Genetique et metabolisme", Universite Bordeaux Segalen, Centre de Reference
      Anomalies du developpement et syndromes malformatifs, 33076 Bordeaux.
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Genetique medicale et ethique.
PL  - France
TA  - J Int Bioethique
JT  - Journal international de bioethique = International journal of bioethics
JID - 9015754
SB  - IM
MH  - Female
MH  - France
MH  - Genetic Testing/ethics
MH  - Genetics, Medical/*ethics
MH  - Humans
MH  - Pregnancy
MH  - Preimplantation Diagnosis/ethics
MH  - Prenatal Diagnosis/ethics
EDAT- 2012/08/29 06:00
MHDA- 2012/10/12 06:00
CRDT- 2012/08/29 06:00
PHST- 2012/08/29 06:00 [entrez]
PHST- 2012/08/29 06:00 [pubmed]
PHST- 2012/10/12 06:00 [medline]
AID - 10.3917/jib.232.0095 [doi]
PST - ppublish
SO  - J Int Bioethique. 2012 Jun;23(2):95-102, 178-9. doi: 10.3917/jib.232.0095.


PMID- 22924192
OWN - NLM
STAT- MEDLINE
DCOM- 20121010
LR  - 20120828
IS  - 1145-0762 (Print)
IS  - 1145-0762 (Linking)
VI  - 23
IP  - 2
DP  - 2012 Jun
TI  - [Bioethics committee in the university teaching hospital in Bordeaux].
PG  - 71-6, 176
AB  - Set up in 2011, the ethics committee at the teaching hospital in Bordeaux,
      although it is now obsolete in its organisation because of the "standardisation" 
      in early 2012 of regional ethics groups, was nevertheless an original structure
      which deserves to be analysed for several reasons. First of all, why have a
      hospital ethics committee? Then, to do what? Finally, it is interesting to give a
      few indications about the working of this committee.
FAU - Daubech, Lin
AU  - Daubech L
AD  - CHU de Bordeaux, 12 rue Dubernat, 33404 Talence Cedex.
      lin.daubech@chu-bordeaux.fr
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Le comite de bioethique du Centre Hospitalier Universitaire de Bordeaux.
PL  - France
TA  - J Int Bioethique
JT  - Journal international de bioethique = International journal of bioethics
JID - 9015754
SB  - IM
MH  - Ethics Committees, Clinical/*organization & administration
MH  - France
MH  - Hospitals, Teaching
MH  - Humans
MH  - Organizational Objectives
EDAT- 2012/08/29 06:00
MHDA- 2012/10/12 06:00
CRDT- 2012/08/29 06:00
PHST- 2012/08/29 06:00 [entrez]
PHST- 2012/08/29 06:00 [pubmed]
PHST- 2012/10/12 06:00 [medline]
PST - ppublish
SO  - J Int Bioethique. 2012 Jun;23(2):71-6, 176.


PMID- 22924189
OWN - NLM
STAT- MEDLINE
DCOM- 20121010
LR  - 20191112
IS  - 1145-0762 (Print)
IS  - 1145-0762 (Linking)
VI  - 23
IP  - 2
DP  - 2012 Jun
TI  - [The difficulty of applying the fundamental right to care for all within the
      French healthcare system: a major ethical and political challenge].
PG  - 33-44, 174
AB  - The incidence of the reform is beginning to make itself felt and reveal a
      profound modification of the behaviour of health professionals in hospitals as
      well as of the financial structure of hospitals.
FAU - Cainne, Perrine
AU  - Cainne P
AD  - Institut d'Etudes Politiques de Toulouse.
LA  - fre
PT  - Journal Article
TT  - La difficile application du droit fondamental aux soins pour tous dans le systeme
      sanitaire francais: un defi ethique et politique majeur.
PL  - France
TA  - J Int Bioethique
JT  - Journal international de bioethique = International journal of bioethics
JID - 9015754
SB  - IM
MH  - *Bioethics
MH  - France
MH  - *Health Care Reform
MH  - *Human Rights
MH  - Humans
MH  - *Politics
MH  - Universal Health Insurance/ethics/*organization & administration
EDAT- 2012/08/29 06:00
MHDA- 2012/10/12 06:00
CRDT- 2012/08/29 06:00
PHST- 2012/08/29 06:00 [entrez]
PHST- 2012/08/29 06:00 [pubmed]
PHST- 2012/10/12 06:00 [medline]
AID - 10.3917/jib.232.0033 [doi]
PST - ppublish
SO  - J Int Bioethique. 2012 Jun;23(2):33-44, 174. doi: 10.3917/jib.232.0033.


PMID- 22913555
OWN - NLM
STAT- MEDLINE
DCOM- 20130107
LR  - 20120823
IS  - 1439-0531 (Electronic)
IS  - 0936-6768 (Linking)
VI  - 47 Suppl 5
DP  - 2012 Aug
TI  - Somatic cell nuclear transfer cloning: practical applications and current
      legislation.
PG  - 2-10
LID - 10.1111/j.1439-0531.2012.02121.x [doi]
AB  - Somatic cloning is emerging as a new biotechnology by which the opportunities
      arising from the advances in molecular genetics and genome analysis can be
      implemented in animal breeding. Significant improvements have been made in SCNT
      protocols in the past years which now allow to embarking on practical
      applications. The main areas of application of SCNT are: Reproductive cloning,
      therapeutic cloning and basic research. A great application potential of SCNT
      based cloning is the production of genetically modified (transgenic) animals.
      Somatic cell nuclear transfer based transgenic animal production has significant 
      advances over the previously employed microinjection of foreign DNA into
      pronuclei of zygotes. This cell based transgenesis is compatible with gene
      targeting and allows both, the addition of a specific gene and the deletion of an
      endogenous gene. Efficient transgenic animal production provides numerous
      opportunities for agriculture and biomedicine. Regulatory agencies around the
      world have agreed that food derived from cloned animals and their offspring is
      safe and there is no scientific basis for questioning this. Commercial
      application of somatic cloning within the EU is via the Novel Food regulation EC 
      No. 258/97. Somatic cloning raises novel questions regarding the ethical and
      moral status of animals and their welfare which has prompted a controversial
      discussion in Europe which has not yet been resolved.
CI  - (c) 2012 Blackwell Verlag GmbH.
FAU - Niemann, H
AU  - Niemann H
AD  - Institute of Farm Animal Genetics, Friedrich-Loeffler-Institut, Federal Research 
      Institute for Animal Health, Mariensee, Neustadt, Germany.
      heiner.niemann@fli.bund.de
FAU - Lucas-Hahn, A
AU  - Lucas-Hahn A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Reprod Domest Anim
JT  - Reproduction in domestic animals = Zuchthygiene
JID - 9015668
SB  - IM
MH  - Agriculture
MH  - Animals
MH  - Animals, Domestic/genetics
MH  - Animals, Genetically Modified
MH  - Breeding/methods
MH  - Cattle
MH  - Cloning, Organism/veterinary
MH  - European Union
MH  - Genetic Variation
MH  - Goats
MH  - Legislation, Food
MH  - Nuclear Transfer Techniques/legislation & jurisprudence/*veterinary
MH  - Swine
EDAT- 2012/08/29 06:00
MHDA- 2013/01/08 06:00
CRDT- 2012/08/24 06:00
PHST- 2012/08/24 06:00 [entrez]
PHST- 2012/08/29 06:00 [pubmed]
PHST- 2013/01/08 06:00 [medline]
AID - 10.1111/j.1439-0531.2012.02121.x [doi]
PST - ppublish
SO  - Reprod Domest Anim. 2012 Aug;47 Suppl 5:2-10. doi:
      10.1111/j.1439-0531.2012.02121.x.


PMID- 22923826
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 0976-2817 (Electronic)
IS  - 0019-5049 (Linking)
VI  - 56
IP  - 3
DP  - 2012 May
TI  - Effect of pre-operative rectal diclofenac suppository on post-operative analgesic
      requirement in cleft palate repair: A randomised clinical trial.
PG  - 265-9
LID - 10.4103/0019-5049.98774 [doi]
AB  - BACKGROUND: Opioid analgesics used for analgesia are associated with sedation,
      respiratory depression and post-operative nausea and vomiting. Non-steroidal
      anti-inflammatory drugs such as diclofenac are a safe and effective alternative
      with opioid-sparing effect. OBJECTIVE: To evaluate the effectiveness of
      pre-operative rectal diclofenac suppository (1 mg/kg) in cleft palate repair for 
      post-operative analgesia and reduction in post-operative opioid requirements.
      STUDY DESIGN: A randomized clinical trial. METHODS: After obtaining approval from
      the institutional ethical committee, 60 children were allocated by a
      computer-generated randomisation into two groups of 30 each; group D (Diclofenac 
      group) and group C (Conventional group). Children in group D and group C were
      similar in all aspects except for the fact that group D children received 1 mg/kg
      diclofenac suppository after induction. Pain was evaluated using modification of 
      the objective pain scale by Hannallah and colleagues for 6 h post-operatively by 
      an anaesthesiology resident or nursing staff who was blinded to the group. If the
      pain score was more than 3, rescue analgesic I.V. fentanyl 0.5 mugm/kg was
      administered. The pain scores at different intervals, number of doses and
      quantity of rescue analgesic required were noted. RESULTS: We observed that
      pre-operative rectal diclofenac provided effective analgesia in the immediate
      post-operative period, as evidenced by reduced pain scores and reduced opioid
      requirement (P=0.00002). There was no evidence of any increased perioperative
      bleeding in the diclofenac group. CONCLUSION: Pre-operative rectal diclofenac
      reduces opioid consumption and provides good post-operative analgesia.
FAU - Adarsh, Es
AU  - Adarsh E
AD  - Department of Anaesthesiology, S N Medical College, Bagalkot, India.
FAU - Mane, Rajesh
AU  - Mane R
FAU - Sanikop, Cs
AU  - Sanikop C
FAU - Sagar, Sm
AU  - Sagar S
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Anaesth
JT  - Indian journal of anaesthesia
JID - 0013243
PMC - PMC3425287
OTO - NOTNLM
OT  - Cleft palate repair
OT  - preemptive analgesia
OT  - rectal diclofenac
EDAT- 2012/08/28 06:00
MHDA- 2012/08/28 06:01
CRDT- 2012/08/28 06:00
PHST- 2012/08/28 06:00 [entrez]
PHST- 2012/08/28 06:00 [pubmed]
PHST- 2012/08/28 06:01 [medline]
AID - 10.4103/0019-5049.98774 [doi]
AID - IJA-56-265 [pii]
PST - ppublish
SO  - Indian J Anaesth. 2012 May;56(3):265-9. doi: 10.4103/0019-5049.98774.


PMID- 22923712
OWN - NLM
STAT- MEDLINE
DCOM- 20130103
LR  - 20121024
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 265
IP  - 2
DP  - 2012 Nov
TI  - Sodium MR imaging of the lumbar intervertebral disk at 7 T: correlation with T2
      mapping and modified Pfirrmann score at 3 T--preliminary results.
PG  - 555-64
LID - 10.1148/radiol.12111920 [doi]
AB  - PURPOSE: To compare sodium imaging of lumbar intervertebral disks in asymptomatic
      volunteers at 7-T magnetic resonance (MR) imaging with quantitative T2 mapping
      and morphologic scoring at 3 T. MATERIALS AND METHODS: Following ethical board
      approval and informed consent, the L2-3 to L5-S1 disks were examined in 10
      asymptomatic volunteers (nine men, one woman; mean age, 30 years; range, 23-43
      years). At 7 T, normalized sodium signal-to-noise ratios were calculated, by
      using region-of-interest analysis. At 3 T, T2 mapping was performed with a
      multiecho spin-echo sequence (repetition time msec/echo times msec, 1500/24, 36, 
      48, 60, 72, 84, 96, 108, 120, 132, 144, 156). T2 values were calculated over the 
      nucleus, with a pixelwise, monoexponential nonnegative least-squares-fit
      analysis. Morphologic grading according to a modified Pfirrmann score was
      assessed independently by three experienced musculoskeletal radiologists, and
      Pearson correlation analysis of the covariates was performed. RESULTS: The mean
      normalized sodium signal intensity was 275.5+/-115.4 (standard deviation). The T2
      mapping showed a mean value of 89.8 msec+/-19.34. The median modified Pfirrmann
      score was 2b (90% had score</=3c). The Pearson correlation coefficient showed a
      cubic function between sodium imaging and the modified Pfirrmann score, a
      moderate inverse correlation between T2 mapping and the modified Pfirrmann score 
      (r=-0.62), and no correlation between sodium imaging and T2 mapping (r=0.06).
      CONCLUSION: The results suggest that MR imaging of the intervertebral disk, using
      sodium imaging and T2 mapping, can help characterize different component changes 
      and that both of these methods are to some degree related to the Pfirrmann score.
CI  - (c) RSNA, 2012
FAU - Noebauer-Huhmann, Iris-Melanie
AU  - Noebauer-Huhmann IM
AD  - MR Centre-High Field MR, Department of Radiology, Division of Neuroradiology and 
      Musculoskeletal Radiology, Medical University of Vienna/Vienna General Hospital, 
      Waerhringer Guertel 18-20, A-1090 Vienna, Austria. iris.noebauer@meduniwien.ac.at
FAU - Juras, Vladimir
AU  - Juras V
FAU - Pfirrmann, Christian W A
AU  - Pfirrmann CW
FAU - Szomolanyi, Pavol
AU  - Szomolanyi P
FAU - Zbyn, Stefan
AU  - Zbyn S
FAU - Messner, Alina
AU  - Messner A
FAU - Wimmer, Johannes
AU  - Wimmer J
FAU - Weber, Michael
AU  - Weber M
FAU - Friedrich, Klaus M
AU  - Friedrich KM
FAU - Stelzeneder, David
AU  - Stelzeneder D
FAU - Trattnig, Siegfried
AU  - Trattnig S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120824
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adult
MH  - *Algorithms
MH  - Female
MH  - Humans
MH  - Image Enhancement/methods
MH  - Image Interpretation, Computer-Assisted/*methods
MH  - Intervertebral Disc/*anatomy & histology
MH  - Lumbar Vertebrae/*anatomy & histology
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Statistics as Topic
MH  - Young Adult
EDAT- 2012/08/28 06:00
MHDA- 2013/01/04 06:00
CRDT- 2012/08/28 06:00
PHST- 2012/08/28 06:00 [entrez]
PHST- 2012/08/28 06:00 [pubmed]
PHST- 2013/01/04 06:00 [medline]
AID - radiol.12111920 [pii]
AID - 10.1148/radiol.12111920 [doi]
PST - ppublish
SO  - Radiology. 2012 Nov;265(2):555-64. doi: 10.1148/radiol.12111920. Epub 2012 Aug
      24.


PMID- 22922596
OWN - NLM
STAT- MEDLINE
DCOM- 20130218
LR  - 20211021
IS  - 1759-5010 (Electronic)
IS  - 1759-5002 (Linking)
VI  - 9
IP  - 10
DP  - 2012 Oct
TI  - Stent choice and the hidden consequences of cost savings.
PG  - 559-60
LID - 10.1038/nrcardio.2012.124 [doi]
AB  - Amin and colleagues have attempted to estimate the cost savings to the US
      health-care system if drug-eluting coronary stents were more selectively used in 
      patients at low risk of restenosis. Their results and conclusions raise
      statistical, societal, and ethical issues that need to be considered before this 
      approach should be widely embraced.
FAU - Cavender, Matthew A
AU  - Cavender MA
AD  - TIMI Study Group, Division of Cardiovascular Medicine, Department of Medicine,
      Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, 
      MA 02115, USA.
FAU - Ellis, Stephen G
AU  - Ellis SG
LA  - eng
PT  - Journal Article
DEP - 20120828
PL  - England
TA  - Nat Rev Cardiol
JT  - Nature reviews. Cardiology
JID - 101500075
RN  - 0 (Platelet Aggregation Inhibitors)
SB  - IM
MH  - Coronary Restenosis/*economics/prevention & control
MH  - Cost Savings/*economics/statistics & numerical data
MH  - Drug-Eluting Stents/*economics/statistics & numerical data
MH  - Humans
MH  - Platelet Aggregation Inhibitors/economics/therapeutic use
MH  - Risk Assessment
MH  - United States
EDAT- 2012/08/28 06:00
MHDA- 2013/02/19 06:00
CRDT- 2012/08/28 06:00
PHST- 2012/08/28 06:00 [entrez]
PHST- 2012/08/28 06:00 [pubmed]
PHST- 2013/02/19 06:00 [medline]
AID - nrcardio.2012.124 [pii]
AID - 10.1038/nrcardio.2012.124 [doi]
PST - ppublish
SO  - Nat Rev Cardiol. 2012 Oct;9(10):559-60. doi: 10.1038/nrcardio.2012.124. Epub 2012
      Aug 28.


PMID- 22922010
OWN - NLM
STAT- MEDLINE
DCOM- 20130122
LR  - 20151119
IS  - 1769-6623 (Electronic)
IS  - 0750-7658 (Linking)
VI  - 31
IP  - 9
DP  - 2012 Sep
TI  - [Euthanasia, assisted suicide and palliative care: a review by the Ethics
      Committee of the French Society of Anaesthesia and Intensive Care].
PG  - 694-703
LID - 10.1016/j.annfar.2012.07.019 [doi]
AB  - CONTEXT: Management of the end of life is a major social issue which was
      addressed in France by law, on April 22nd 2005. Nevertheless, a debate has
      emerged within French society about the legalization of euthanasia and/or
      assisted suicide (E/AS). This issue raises questions for doctors and most
      especially for anesthetists and intensive care physicians. OBJECTIVE: To
      highlight, dispassionately and without dogmatism, key points taken from the
      published literature and the experience of countries which have legislated for
      E/AS. RESULTS: The current French law addresses most of the end of life issues an
      intensive care physician might encounter. It is credited for imposing palliative 
      care when therapies have become senseless and are withdrawn. However, this
      requirement for palliative care is generally applied too late in the course of a 
      fatal illness. There is a great need for more education and stronger incentives
      for early action in this area. On the rare occasions when E/AS is requested,
      either by the patient or their loved-ones, it often results from a failure to
      consider that treatments have become senseless and conflict with patient's best
      interest. The implementation of E/AS cannot be reduced to a simple affirmation of
      the Principle of autonomy. Such procedures present genuine difficulties and the
      risk of drift. CONCLUSION: We deliver a message of prudence and caution. Should
      we address painful end of life and moral suffering issues, by suppressing the
      subject, i.e. ending the patient's life, when comprehensive palliative care has
      not first been fully granted to all patients in need of it ?
CI  - Copyright (c) 2012 Societe francaise d'anesthesie et de reanimation (Sfar).
      Published by Elsevier SAS. All rights reserved.
FAU - Beydon, L
AU  - Beydon L
AD  - Pole d'anesthesie-reanimation, centre hospitalier universitaire d'Angers, 4, rue 
      Larrey, 49033 Angers cedex 01, France. lbeydon.angers@invivo.edu
FAU - Pelluchon, C
AU  - Pelluchon C
FAU - Beloucif, S
AU  - Beloucif S
FAU - Baghdadi, H
AU  - Baghdadi H
FAU - Baumann, A
AU  - Baumann A
FAU - Bazin, J-E
AU  - Bazin JE
FAU - Bizouarn, P
AU  - Bizouarn P
FAU - Crozier, S
AU  - Crozier S
FAU - Devalois, B
AU  - Devalois B
FAU - Eon, B
AU  - Eon B
FAU - Fieux, F
AU  - Fieux F
FAU - Frot, C
AU  - Frot C
FAU - Gisquet, E
AU  - Gisquet E
FAU - Guibet Lafaye, C
AU  - Guibet Lafaye C
FAU - Kentish-Barnes, N
AU  - Kentish-Barnes N
FAU - Muzard, O
AU  - Muzard O
FAU - Nicolas-Robin, A
AU  - Nicolas-Robin A
FAU - Lopez, M O
AU  - Lopez MO
FAU - Roussin, F
AU  - Roussin F
FAU - Puybasset, L
AU  - Puybasset L
CN  - Sfar
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Fin de vie, euthanasie et suicide assiste : une mise au point de la Societe
      francaise d'anesthesie et de reanimation (Sfar).
DEP - 20120822
PL  - France
TA  - Ann Fr Anesth Reanim
JT  - Annales francaises d'anesthesie et de reanimation
JID - 8213275
SB  - IM
MH  - Anesthesiology/*ethics/legislation & jurisprudence
MH  - Critical Care/ethics
MH  - Ethics Committees
MH  - Europe
MH  - Euthanasia/*ethics/legislation & jurisprudence
MH  - Family
MH  - France
MH  - Humans
MH  - Legislation, Medical
MH  - Oregon
MH  - Palliative Care/*ethics/legislation & jurisprudence
MH  - Physicians
MH  - Societies, Medical
MH  - Suicide, Assisted/*ethics/legislation & jurisprudence
MH  - Terminal Care/ethics
EDAT- 2012/08/28 06:00
MHDA- 2013/01/23 06:00
CRDT- 2012/08/28 06:00
PHST- 2012/07/11 00:00 [received]
PHST- 2012/07/19 00:00 [accepted]
PHST- 2012/08/28 06:00 [entrez]
PHST- 2012/08/28 06:00 [pubmed]
PHST- 2013/01/23 06:00 [medline]
AID - S0750-7658(12)00313-9 [pii]
AID - 10.1016/j.annfar.2012.07.019 [doi]
PST - ppublish
SO  - Ann Fr Anesth Reanim. 2012 Sep;31(9):694-703. doi: 10.1016/j.annfar.2012.07.019. 
      Epub 2012 Aug 22.


PMID- 22921912
OWN - NLM
STAT- MEDLINE
DCOM- 20121210
LR  - 20121001
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 98
IP  - 4
DP  - 2012 Oct
TI  - Turner syndrome: new insights into an old disorder.
PG  - 773-4
LID - 10.1016/j.fertnstert.2012.07.1138 [doi]
LID - S0015-0282(12)01891-2 [pii]
AB  - There have been marked advances in the understanding and treatment of Turner
      syndrome since its initial description in 1938. Greater knowledge of the
      heterogeneity of phenotypes, early treatment interventions with growth hormone
      and hormonal replacement, the risks of reproduction, spontaneous and assisted,
      and the long-term health of women with Turner syndrome has been achieved in the
      interim. But many perplexing ethical and clinical issues persist.
CI  - Copyright (c) 2012 American Society for Reproductive Medicine. Published by
      Elsevier Inc. All rights reserved.
FAU - Legro, Richard S
AU  - Legro RS
AD  - Department of Obstetrics and Gynecology, Pennsylvania State University College of
      Medicine, Hershey, Pennsylvania 17033, USA. RSL1@PSU.EDU
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120824
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
SB  - IM
MH  - Female
MH  - Humans
MH  - Phenotype
MH  - Reproduction/*physiology
MH  - Turner Syndrome/*genetics/physiopathology/*therapy
EDAT- 2012/08/28 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/08/28 06:00
PHST- 2012/07/27 00:00 [received]
PHST- 2012/07/30 00:00 [accepted]
PHST- 2012/08/28 06:00 [entrez]
PHST- 2012/08/28 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - S0015-0282(12)01891-2 [pii]
AID - 10.1016/j.fertnstert.2012.07.1138 [doi]
PST - ppublish
SO  - Fertil Steril. 2012 Oct;98(4):773-4. doi: 10.1016/j.fertnstert.2012.07.1138. Epub
      2012 Aug 24.


PMID- 22921330
OWN - NLM
STAT- MEDLINE
DCOM- 20130306
LR  - 20151119
IS  - 1532-6586 (Electronic)
IS  - 0161-4754 (Linking)
VI  - 35
IP  - 6
DP  - 2012 Jul
TI  - Ethics education in chiropractic colleges: a North American survey.
PG  - 486-90
LID - 10.1016/j.jmpt.2012.07.005 [doi]
AB  - OBJECTIVE: The purposes of this study were to survey Council on Chiropractic
      Education-accredited chiropractic colleges in North America and to describe
      curricular details on the teaching of bioethics. METHODS: A custom-designed
      survey was sent to chiropractic colleges. Total number of contact hours, whether 
      the ethics was a stand-alone course or integrated elsewhere, type of instructor, 
      and if there was a required or recommended course text were queried. RESULTS: Of 
      19 surveys sent by mail, 15 surveys were returned. The average time in ethics
      instruction was 18.7 hours including lecture format, small group tutorial, and
      self-study. Chiropractic ethics education includes 8 areas of content
      (boundaries, law and jurisprudence, professionalism, basic ethic
      tenets/principles, ethical codes of conduct, prevention of financial and of
      sexual abuse, and resolving an ethical dilemma). Some colleges include content
      taught to students under the domain of law and jurisprudence. CONCLUSION: The
      results of this survey indicate that there are opportunities to further develop
      the educational ethics program at Council on Chiropractic Education-accredited
      colleges. All colleges currently offer bioethics teaching. An expanded role for
      this content is recommended so as to offer optimal benefit for students and
      practitioners.
CI  - Copyright (c) 2012 National University of Health Sciences. Published by Mosby,
      Inc. All rights reserved.
FAU - Kinsinger, Stuart
AU  - Kinsinger S
AD  - Canadian Memorial Chiropractic College, Toronto, Ontario, Canada.
      skinsinger@cmcc.ca
FAU - Soave, David
AU  - Soave D
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20120824
PL  - United States
TA  - J Manipulative Physiol Ther
JT  - Journal of manipulative and physiological therapeutics
JID - 7807107
SB  - IM
MH  - Adult
MH  - Bioethics/education
MH  - Chiropractic/*education
MH  - Cross-Sectional Studies
MH  - *Curriculum
MH  - Education, Medical, Graduate/ethics/methods
MH  - Ethics, Medical/*education
MH  - Female
MH  - Humans
MH  - Male
MH  - North America
MH  - Quality Control
MH  - Surveys and Questionnaires
EDAT- 2012/08/28 06:00
MHDA- 2013/03/07 06:00
CRDT- 2012/08/28 06:00
PHST- 2010/10/14 00:00 [received]
PHST- 2011/12/22 00:00 [revised]
PHST- 2012/01/13 00:00 [accepted]
PHST- 2012/08/28 06:00 [entrez]
PHST- 2012/08/28 06:00 [pubmed]
PHST- 2013/03/07 06:00 [medline]
AID - S0161-4754(12)00126-1 [pii]
AID - 10.1016/j.jmpt.2012.07.005 [doi]
PST - ppublish
SO  - J Manipulative Physiol Ther. 2012 Jul;35(6):486-90. doi:
      10.1016/j.jmpt.2012.07.005. Epub 2012 Aug 24.


PMID- 22921193
OWN - NLM
STAT- MEDLINE
DCOM- 20121107
LR  - 20131121
IS  - 1545-1534 (Electronic)
IS  - 1080-6032 (Linking)
VI  - 23
IP  - 3
DP  - 2012 Sep
TI  - Medical and sporting ethics of high altitude mountaineering: the use of drugs and
      supplemental oxygen.
PG  - 205-6
LID - 10.1016/j.wem.2012.03.011 [doi]
FAU - Wagner, Dale R
AU  - Wagner DR
LA  - eng
PT  - Editorial
PL  - United States
TA  - Wilderness Environ Med
JT  - Wilderness & environmental medicine
JID - 9505185
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - I9ZF7L6G2L (Nifedipine)
RN  - O3FX965V0I (Acetazolamide)
RN  - S88TT14065 (Oxygen)
SB  - IM
CIN - Wilderness Environ Med. 2013 Jun;24(2):173-4. PMID: 23434166
MH  - Acetazolamide/therapeutic use
MH  - Altitude Sickness/*therapy
MH  - Dexamethasone/therapeutic use
MH  - Humans
MH  - Mountaineering/*ethics
MH  - Nifedipine/therapeutic use
MH  - Oxygen/administration & dosage
MH  - Oxygen Inhalation Therapy/ethics/methods
MH  - Wilderness Medicine/*ethics
EDAT- 2012/08/28 06:00
MHDA- 2012/11/08 06:00
CRDT- 2012/08/28 06:00
PHST- 2012/03/18 00:00 [received]
PHST- 2012/03/19 00:00 [accepted]
PHST- 2012/08/28 06:00 [entrez]
PHST- 2012/08/28 06:00 [pubmed]
PHST- 2012/11/08 06:00 [medline]
AID - S1080-6032(12)00103-2 [pii]
AID - 10.1016/j.wem.2012.03.011 [doi]
PST - ppublish
SO  - Wilderness Environ Med. 2012 Sep;23(3):205-6. doi: 10.1016/j.wem.2012.03.011.


PMID- 22921129
OWN - NLM
STAT- MEDLINE
DCOM- 20130118
LR  - 20220318
IS  - 1879-1972 (Electronic)
IS  - 1054-139X (Linking)
VI  - 51
IP  - 3
DP  - 2012 Sep
TI  - The intersection of youth, technology, and new media with sexual health: moving
      the research agenda forward.
PG  - 207-12
LID - 10.1016/j.jadohealth.2012.06.012 [doi]
AB  - Youth bear a significant proportion of the sexually transmitted infection
      (STI)/HIV burden in the United States, CDC, 2010. Available at:
      http://www.cdc.gov/std/stats09/default.htm, with rates of some STIs increasing
      among youth of color and young men who have sex with men. Technology use among
      youth also continues to increase. The ubiquitous nature of technology use among
      youth offers a multitude of opportunities to promote youth sexual health and to
      prevent disease transmission and unplanned pregnancies. To date, there have been 
      a handful of peer-reviewed articles published regarding the feasibility,
      acceptability, and effectiveness of using new media and technology for sexual
      health promotion. Despite recent publications, there is still a real need for
      high-quality research to understand the impact of different forms of new media
      use on youth sexual health, as well as to determine the best ways to harness
      technology to promote safer sex behaviors, both for the short- and long-term. In 
      March 2011, Internet Sexuality Information Services (ISIS), National Institute of
      Mental Health (NIMH), and the Ford Foundation convened a meeting of scientists
      and technology experts to discuss how to effectively conduct sexual health
      promotion research using new forms of technology. The meeting was structured to
      cover the following topic areas: (i) research-community partnerships, (ii)
      institutional review board and ethical issues, (iii) theoretical frameworks, (iv)
      intervention approaches, (v) recruitment methods, and (vi) assessing impact.
      Presentations included case studies of successful technology-based HIV/STI
      prevention interventions for youth, which led to broader discussions on how to
      conduct research in this area. This article summarizes the meeting proceedings,
      highlights key points, offers recommendations, and outlines future directions.
CI  - Copyright (c) 2012 Society for Adolescent Health and Medicine. Published by
      Elsevier Inc. All rights reserved.
FAU - Allison, Susannah
AU  - Allison S
AD  - National Institute of Mental Health, National Institutes of Health, Bethesda,
      Maryland, USA.
FAU - Bauermeister, Jose A
AU  - Bauermeister JA
FAU - Bull, Sheana
AU  - Bull S
FAU - Lightfoot, Marguerita
AU  - Lightfoot M
FAU - Mustanski, Brian
AU  - Mustanski B
FAU - Shegog, Ross
AU  - Shegog R
FAU - Levine, Deb
AU  - Levine D
LA  - eng
GR  - K01 MH087242/MH/NIMH NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - J Adolesc Health
JT  - The Journal of adolescent health : official publication of the Society for
      Adolescent Medicine
JID - 9102136
SB  - IM
MH  - Adolescent
MH  - *Behavioral Research
MH  - *Communications Media
MH  - Ethics Committees, Research
MH  - Ethics, Research
MH  - Female
MH  - Health Promotion
MH  - Humans
MH  - Male
MH  - Patient Selection
MH  - *Reproductive Health
MH  - Social Support
PMC - PMC4330086
MID - NIHMS515790
EDAT- 2012/08/28 06:00
MHDA- 2013/01/19 06:00
CRDT- 2012/08/28 06:00
PHST- 2012/06/04 00:00 [received]
PHST- 2012/06/11 00:00 [accepted]
PHST- 2012/08/28 06:00 [entrez]
PHST- 2012/08/28 06:00 [pubmed]
PHST- 2013/01/19 06:00 [medline]
AID - S1054-139X(12)00254-6 [pii]
AID - 10.1016/j.jadohealth.2012.06.012 [doi]
PST - ppublish
SO  - J Adolesc Health. 2012 Sep;51(3):207-12. doi: 10.1016/j.jadohealth.2012.06.012.


PMID- 22921012
OWN - NLM
STAT- MEDLINE
DCOM- 20130325
LR  - 20211021
IS  - 1477-7827 (Electronic)
IS  - 1477-7827 (Linking)
VI  - 10
DP  - 2012 Aug 25
TI  - Non-invasive assessment of the reproductive cycle in free-ranging female African 
      elephants (Loxodonta africana) treated with a gonadotropin-releasing hormone
      (GnRH) vaccine for inducing anoestrus.
PG  - 63
LID - 10.1186/1477-7827-10-63 [doi]
AB  - BACKGROUND: In southern Africa, various options to manage elephant populations
      are being considered. Immunocontraception is considered to be the most ethically 
      acceptable and logistically feasible method for control of smaller and confined
      populations. In this regard, the use of gonadotropin-releasing hormone (GnRH)
      vaccine has not been investigated in female elephants, although it has been
      reported to be safe and effective in several domestic and wildlife species. The
      aims of this study were to monitor the oestrous cycles of free-ranging African
      elephant cows using faecal progestagen metabolites and to evaluate the efficacy
      of a GnRH vaccine to induce anoestrus in treated cows. METHODS: Between May
      2009-June 2010, luteal activity of 12 elephant cows was monitored non-invasively 
      using an enzyme immunoassay detecting faecal 5alpha-reduced pregnanes (faecal
      progestagen metabolites, FPM) on a private game reserve in South Africa. No bulls
      of breeding age were present on the reserve prior to and for the duration of the 
      study. After a 3-month control period, 8 randomly-selected females were treated
      twice with 600 micrograms of GnRH vaccine (Improvac(R), Pfizer Animal Health,
      Sandton, South Africa) 5-7 weeks apart. Four of these females had been treated
      previously with the porcine zona pellucida (pZP) vaccine for four years
      (2004-2007). RESULTS: All 12 monitored females (8 treated and 4 controls) showed 
      signs of luteal activity as evidenced by FPM concentrations exceeding individual 
      baseline values more than once. A total of 16 oestrous cycles could be identified
      in 8 cows with four of these within the 13 to 17 weeks range previously reported 
      for captive African elephants. According to the FPM concentrations the GnRH
      vaccine was unable to induce anoestrus in the treated cows. Overall FPM levels in
      samples collected during the wet season (mean 4.03 micrograms/gram dry faeces)
      were significantly higher (P<0.002) than the dry season (mean 2.59
      micrograms/gram dry faeces). CONCLUSIONS: The GnRH vaccination protocol failed to
      induce anoestrus in the treated female elephants. These results indicate that
      irregular oestrous cycles occur amongst free-ranging elephants and are not
      restricted to elephants in captivity. The relationship between ecological
      conditions and endocrine activity were confirmed. Free-ranging female elephants
      were observed to not cycle continuously throughout the year in the absence of
      adult bulls.
FAU - Benavides Valades, Gabriela
AU  - Benavides Valades G
AD  - Department of Production Animal Studies, Faculty of Veterinary Science,
      University of Pretoria, Onderstepoort, RSA. gabeva@yahoo.com
FAU - Ganswindt, Andre
AU  - Ganswindt A
FAU - Annandale, Henry
AU  - Annandale H
FAU - Schulman, Martin L
AU  - Schulman ML
FAU - Bertschinger, Henk J
AU  - Bertschinger HJ
LA  - eng
PT  - Journal Article
DEP - 20120825
PL  - England
TA  - Reprod Biol Endocrinol
JT  - Reproductive biology and endocrinology : RB&E
JID - 101153627
RN  - 0 (Progestins)
RN  - 0 (Vaccines)
RN  - 33515-09-2 (Gonadotropin-Releasing Hormone)
SB  - IM
MH  - Anestrus/*drug effects/*physiology
MH  - Animals
MH  - Animals, Wild
MH  - Contraception, Immunologic/methods/*veterinary
MH  - Ecology
MH  - Elephants/*physiology
MH  - Enzyme-Linked Immunosorbent Assay/methods
MH  - Estrous Cycle/drug effects/physiology
MH  - Feces/chemistry
MH  - Female
MH  - Gonadotropin-Releasing Hormone/*pharmacology
MH  - Population Control/methods
MH  - Progestins/analysis/metabolism
MH  - Seasons
MH  - South Africa
MH  - Vaccines/*pharmacology
PMC - PMC3485135
EDAT- 2012/08/28 06:00
MHDA- 2013/03/26 06:00
CRDT- 2012/08/28 06:00
PHST- 2012/05/22 00:00 [received]
PHST- 2012/08/21 00:00 [accepted]
PHST- 2012/08/28 06:00 [entrez]
PHST- 2012/08/28 06:00 [pubmed]
PHST- 2013/03/26 06:00 [medline]
AID - 1477-7827-10-63 [pii]
AID - 10.1186/1477-7827-10-63 [doi]
PST - epublish
SO  - Reprod Biol Endocrinol. 2012 Aug 25;10:63. doi: 10.1186/1477-7827-10-63.


PMID- 22920956
OWN - NLM
STAT- MEDLINE
DCOM- 20130117
LR  - 20220419
IS  - 1933-0693 (Electronic)
IS  - 0022-3085 (Linking)
VI  - 117
IP  - 4
DP  - 2012 Oct
TI  - The role of decompressive craniectomy in cerebral venous sinus thrombosis.
PG  - 738-44
LID - 10.3171/2012.6.JNS11102 [doi]
AB  - OBJECT: Studies on the role of decompressive craniectomy for cerebral venous
      sinus thrombosis (CVST) in the literature are scanty. Randomized trials face a
      lot of drawbacks, including ethical issues. In this article the authors discuss
      their experience with this procedure for CVST and review the available
      literature. METHODS: This study was a retrospective analysis of all patients who 
      underwent decompressive craniectomy for CVST between August 2006 and June 2008 at
      the National Institute of Mental Health and Neurosciences. The cases were
      evaluated for demographic and clinicoradiological features, operative findings,
      and outcome of surgery. Ethical clearance was obtained from the institutional
      ethics committee. The data for each patient were obtained from the database of
      the department. Follow-up data were obtained either through direct clinical
      evaluation or mailed self-report questionnaire. The Glasgow Outcome Scale (GOS)
      and the Rankin Disability Scale were used to assess the outcome. RESULTS: A total
      of 34 patients (13 men and 21 women) were included; their mean age was 31.6
      years, with a range from 18 to 65 years. In univariate analysis, the Glasgow Coma
      Scale (GCS) score prior to surgery and that in the immediate postoperative period
      had a statistically significant correlation with poor outcome. The GCS score
      immediately postoperatively was the only independent, significant predictor of
      poor outcome on multivariate analysis. CONCLUSIONS: Decompressive craniectomy in 
      a selected cohort of patients had a good outcome in a majority of the patients:
      26 of 34 in this study had a GOS score of 4 or 5. In this series, which is the
      largest in the available literature, the authors review their experience and
      recommend usage of this procedure in selected patients.
FAU - Rajan Vivakaran, Thanga Thirupathi
AU  - Rajan Vivakaran TT
AD  - Department of Neurosurgery, National Institute of Mental Health and
      Neurosciences, Bangalore, Karnataka, India.
FAU - Srinivas, Dwarakanath
AU  - Srinivas D
FAU - Kulkarni, Girish Baburao
AU  - Kulkarni GB
FAU - Somanna, Sampath
AU  - Somanna S
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120824
PL  - United States
TA  - J Neurosurg
JT  - Journal of neurosurgery
JID - 0253357
SB  - IM
CIN - J Neurosurg. 2012 Oct;117(4):735-7. PMID: 22920961
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Decompressive Craniectomy
MH  - Female
MH  - Follow-Up Studies
MH  - Glasgow Outcome Scale
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Retrospective Studies
MH  - Sinus Thrombosis, Intracranial/*diagnosis/*surgery
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2012/08/28 06:00
MHDA- 2013/01/18 06:00
CRDT- 2012/08/28 06:00
PHST- 2012/08/28 06:00 [entrez]
PHST- 2012/08/28 06:00 [pubmed]
PHST- 2013/01/18 06:00 [medline]
AID - 10.3171/2012.6.JNS11102 [doi]
PST - ppublish
SO  - J Neurosurg. 2012 Oct;117(4):738-44. doi: 10.3171/2012.6.JNS11102. Epub 2012 Aug 
      24.


PMID- 22920772
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20120827
IS  - 1878-7487 (Electronic)
IS  - 1752-928X (Linking)
VI  - 19
IP  - 7
DP  - 2012 Oct
TI  - Medical error reporting should it be mandatory in Scotland?
PG  - 437-41
LID - 10.1016/j.jflm.2012.04.007 [doi]
AB  - Healthcare professionals have an ethical and professional responsibility to
      report medical errors. Doctors in particular are duty bound to consider the best 
      interests of their patients and 'do no harm'. Medical errors are rarely due to
      individual human error but are often systems based and in many cases are
      avoidable. Reporting and learning from medical errors improves the safety of
      patients. It has been over ten years since the reports To Err Is Human and An
      Organisation with a Memory highlighted the scale of preventable medical errors.
      These statistics, stimulated worldwide health organisations to prioritise patient
      safety. Both reports recommended the implementation of a voluntary near-miss
      reporting system and mandatory reporting of serious adverse incidents that had
      caused physical or psychological harm or death. Currently in Scotland reporting
      of all errors is voluntary and there is no sharing of information between Health 
      Boards. Studies have demonstrated failings of the voluntary system and
      preventable medical errors are still occurring in Scotland. The UK Government in 
      England as of April 2010 has changed the voluntary system of reporting serious
      adverse events to a mandatory obligation. Failure to report may result in a fine 
      of pound4000 to the Trust. Patient groups wish the system in Scotland to become
      mandatory with public disclosure. This would ensure openness, honesty and
      autonomy for patients. This article reviews the controversial issue of mandatory 
      reporting and whether or not this would improve the safety of patients. In
      conclusion, Scotland would benefit from mandatory reporting of serious adverse
      events and voluntary near-miss reporting.
CI  - Copyright (c) 2012 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All
      rights reserved.
FAU - Eadie, Anne
AU  - Eadie A
AD  - Dundee University, Dundee, United Kingdom. a.z.eadie@dundee.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20120516
PL  - England
TA  - J Forensic Leg Med
JT  - Journal of forensic and legal medicine
JID - 101300022
SB  - IM
MH  - England
MH  - Ethics, Medical
MH  - Humans
MH  - Malpractice
MH  - *Mandatory Reporting
MH  - *Medical Errors
MH  - Organizational Culture
MH  - Public Policy
MH  - Scotland
EDAT- 2012/08/28 06:00
MHDA- 2013/02/13 06:00
CRDT- 2012/08/28 06:00
PHST- 2011/09/14 00:00 [received]
PHST- 2012/02/19 00:00 [revised]
PHST- 2012/04/21 00:00 [accepted]
PHST- 2012/08/28 06:00 [entrez]
PHST- 2012/08/28 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
AID - S1752-928X(12)00080-7 [pii]
AID - 10.1016/j.jflm.2012.04.007 [doi]
PST - ppublish
SO  - J Forensic Leg Med. 2012 Oct;19(7):437-41. doi: 10.1016/j.jflm.2012.04.007. Epub 
      2012 May 16.


PMID- 22920404
OWN - NLM
STAT- MEDLINE
DCOM- 20121029
LR  - 20211021
IS  - 1879-1883 (Electronic)
IS  - 0002-9610 (Linking)
VI  - 204
IP  - 3
DP  - 2012 Sep
TI  - Trials and tribulations: the professional development of surgical trialists.
PG  - 339-346.e5
LID - 10.1016/j.amjsurg.2011.11.008 [doi]
AB  - BACKGROUND: Regulatory and professional bodies issue an ever-increasing number of
      guidance documents on the ethics and methods of clinical trials, but the quality 
      of clinical trials of invasive therapeutic procedures continues to be a concern. 
      We interviewed aspiring and accomplished surgical trialists to understand how
      they use guidance documents and other resources in their work. METHODS: We
      performed a qualitative research study involving semistructured interviews of a
      diverse sample of 15 surgical trialists. RESULTS: Professional development as a
      surgical trialist was haphazard, inefficient, and marked by avoidable mistakes.
      Four types of resources played constructive roles: formal education; written
      materials on clinical trials; experience with actual trials; and interpersonal
      interactions with peers, experts, collaborators, and mentors. Recommendations for
      improvement centered on education, mentoring, networking, participating in
      trials, and facilitation by department chairs. CONCLUSIONS: The haphazard and
      unstructured nature of the current system is adding unnecessarily to the numerous
      challenges faced by surgical trialists.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Jarman, Anna F
AU  - Jarman AF
AD  - Department of Surgery, The Methodist Hospital, Houston, TX, USA.
FAU - Wray, Nelda P
AU  - Wray NP
FAU - Wenner, Danielle M
AU  - Wenner DM
FAU - Ashton, Carol M
AU  - Ashton CM
LA  - eng
GR  - R01 CA134995/CA/NCI NIH HHS/United States
GR  - R01 CA134995-03/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Am J Surg
JT  - American journal of surgery
JID - 0370473
SB  - IM
MH  - Adult
MH  - *Clinical Trials as Topic/methods/standards/trends
MH  - Education, Medical, Continuing
MH  - Female
MH  - Humans
MH  - Interprofessional Relations
MH  - Interviews as Topic/methods/statistics & numerical data
MH  - Male
MH  - Mentors
MH  - Middle Aged
MH  - Qualitative Research
MH  - Research Personnel/*education
MH  - *Surgical Procedures, Operative
PMC - PMC3567847
MID - NIHMS368921
EDAT- 2012/08/28 06:00
MHDA- 2012/10/30 06:00
CRDT- 2012/08/28 06:00
PHST- 2011/08/12 00:00 [received]
PHST- 2011/11/18 00:00 [revised]
PHST- 2011/11/18 00:00 [accepted]
PHST- 2012/08/28 06:00 [entrez]
PHST- 2012/08/28 06:00 [pubmed]
PHST- 2012/10/30 06:00 [medline]
AID - S0002-9610(12)00171-7 [pii]
AID - 10.1016/j.amjsurg.2011.11.008 [doi]
PST - ppublish
SO  - Am J Surg. 2012 Sep;204(3):339-346.e5. doi: 10.1016/j.amjsurg.2011.11.008.


PMID- 22920333
OWN - NLM
STAT- MEDLINE
DCOM- 20130122
LR  - 20120827
IS  - 1166-7087 (Print)
IS  - 1166-7087 (Linking)
VI  - 22
IP  - 10
DP  - 2012 Sep
TI  - [Assisted reproductive technologies with sperm donation].
PG  - 561-7
LID - 10.1016/j.purol.2012.04.014 [doi]
AB  - INTRODUCTION: The purpose of this review is to relate to the operating rules of
      CECOS in France and the legal, medical and ethical issues raised by sperm
      donation. MATERIAL AND METHODS: Review of articles and consensus conferences on
      this subject published in Medline (PubMed) selected from 1973 and 2011 according 
      to their relevance and Acts recorded on official legislative French websites.
      RESULTS: The operating rules of CECOS were established by the Act of July 29,
      2004, revised 6 August 2004 and July 7, 2011. Of the 21,759 children born of ART 
      in France in 2009, 5.1% are from a sperm donation. From 1973 to 2006, 44,045
      children are born after a sperm donation. Between 1973 and 2006, 16,971 donors
      are presented in the CECOS and only 10,347 donors have completely made their
      donation process. The main indication for use of donor sperm (75% of
      applications) is represented by men of infertile couples with nonobstructive
      azoospermia, the second indication is infertile men with oligospermia. In
      azoospermia, the application is usually performed after failure of testicular or 
      epididymal surgical specimen. In oligozoospermia, claims made most often after
      several failures of intraconjugal ART. CONCLUSION: Many questions are still
      present around the conception of children by sperm donation. The legitimacy of
      maintaining anonymity in the gift remains widely debated.
CI  - Copyright (c) 2012 Elsevier Masson SAS. All rights reserved.
FAU - Rives, N
AU  - Rives N
AD  - Laboratoire de biologie de la reproduction-CECOS, CHU-hopitaux de Rouen,
      universite de Rouen, CHU Charles-Nicolle, 1, rue de Germont, 76031 Rouen cedex,
      France.
FAU - Sibert, L
AU  - Sibert L
FAU - Perdrix, A
AU  - Perdrix A
FAU - Hennebicq, S
AU  - Hennebicq S
FAU - Julliard, J-C
AU  - Julliard JC
CN  - la Federation francaise des CECOS
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Assistance medicale a la procreation avec don de spermatozoides.
DEP - 20120531
PL  - France
TA  - Prog Urol
JT  - Progres en urologie : journal de l'Association francaise d'urologie et de la
      Societe francaise d'urologie
JID - 9307844
SB  - IM
MH  - France
MH  - Humans
MH  - Male
MH  - *Reproductive Techniques, Assisted/ethics/legislation & jurisprudence
MH  - *Spermatozoa
MH  - *Tissue Donors/ethics/legislation & jurisprudence
EDAT- 2012/08/28 06:00
MHDA- 2013/01/23 06:00
CRDT- 2012/08/28 06:00
PHST- 2012/03/30 00:00 [received]
PHST- 2012/03/30 00:00 [revised]
PHST- 2012/04/18 00:00 [accepted]
PHST- 2012/08/28 06:00 [entrez]
PHST- 2012/08/28 06:00 [pubmed]
PHST- 2013/01/23 06:00 [medline]
AID - S1166-7087(12)00130-3 [pii]
AID - 10.1016/j.purol.2012.04.014 [doi]
PST - ppublish
SO  - Prog Urol. 2012 Sep;22(10):561-7. doi: 10.1016/j.purol.2012.04.014. Epub 2012 May
      31.


PMID- 22920024
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20120827
IS  - 8755-0229 (Print)
IS  - 8755-0229 (Linking)
VI  - 28
IP  - 1
DP  - 2012 Jul-Aug
TI  - Marketing and medicine: a questionable mix.
PG  - 33-6
AB  - Historically, medicine has been an evolving art and science. It never remains the
      same. Only in the past few decades has it been acceptable for doctors to market
      and promote their practices. This article will review the history of medical
      marketing and provide ethical examples of marketing that might be available to
      any physician, in any practice, and in any geographic location.
FAU - Moran, Michael E
AU  - Moran ME
AD  - Arizona Itnstitute of Urology, 1100 N. El Dorado Place, Tucson, AZ 85715, USA.
      doctorwhiz@gmail.com
FAU - Baum, Neil H
AU  - Baum NH
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - J Med Pract Manage
JT  - The Journal of medical practice management : MPM
JID - 8605494
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Marketing of Health Services/*history/*organization & administration
MH  - Mass Media
MH  - Practice Management, Medical/*history/*organization & administration
MH  - Social Media
MH  - Societies, Medical/organization & administration
EDAT- 2012/08/28 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/08/28 06:00
PHST- 2012/08/28 06:00 [entrez]
PHST- 2012/08/28 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
PST - ppublish
SO  - J Med Pract Manage. 2012 Jul-Aug;28(1):33-6.


PMID- 22919943
OWN - NLM
STAT- MEDLINE
DCOM- 20121002
LR  - 20181201
IS  - 0025-4800 (Print)
IS  - 0025-4800 (Linking)
VI  - 61
IP  - 1
DP  - 2012 Spring
TI  - Prescription writing for dentists: ethical and legal guidelines.
PG  - 6
FAU - Maitland, Ronald I
AU  - Maitland RI
LA  - eng
PT  - Letter
PT  - Comment
PL  - United States
TA  - J Mass Dent Soc
JT  - Journal of the Massachusetts Dental Society
JID - 7503082
CON - J Mass Dent Soc. 2012 Winter;60(4):28-31. PMID: 22919936
MH  - *Dentists
MH  - *Ethics, Dental
MH  - Humans
MH  - *Prescriptions
EDAT- 2012/08/28 06:00
MHDA- 2012/10/04 06:00
CRDT- 2012/08/28 06:00
PHST- 2012/08/28 06:00 [entrez]
PHST- 2012/08/28 06:00 [pubmed]
PHST- 2012/10/04 06:00 [medline]
PST - ppublish
SO  - J Mass Dent Soc. 2012 Spring;61(1):6.


PMID- 22919936
OWN - NLM
STAT- MEDLINE
DCOM- 20120918
LR  - 20121002
IS  - 0025-4800 (Print)
IS  - 0025-4800 (Linking)
VI  - 60
IP  - 4
DP  - 2012 Winter
TI  - Prescription writing for dentists: ethical and legal guidelines.
PG  - 28-31
FAU - Harold, Richard S
AU  - Harold RS
AD  - Department of General Dentistry, Tufts University School of Dental Medicine, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Mass Dent Soc
JT  - Journal of the Massachusetts Dental Society
JID - 7503082
CIN - J Mass Dent Soc. 2012 Spring;61(1):6. PMID: 22919943
MH  - *Dentists/ethics/legislation & jurisprudence
MH  - Drug-Seeking Behavior
MH  - *Ethics, Dental
MH  - Guidelines as Topic
MH  - Humans
MH  - Inappropriate Prescribing
MH  - Massachusetts
MH  - *Prescriptions
EDAT- 2012/08/28 06:00
MHDA- 2012/09/19 06:00
CRDT- 2012/08/28 06:00
PHST- 2012/08/28 06:00 [entrez]
PHST- 2012/08/28 06:00 [pubmed]
PHST- 2012/09/19 06:00 [medline]
PST - ppublish
SO  - J Mass Dent Soc. 2012 Winter;60(4):28-31.


PMID- 22919859
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20120827
IS  - 0023-9852 (Print)
IS  - 0023-9852 (Linking)
VI  - 60
IP  - 2
DP  - 2012 Apr-Jun
TI  - On the ethics of placebo-controlled trials.
PG  - 63-4
FAU - Ephrem, Georges
AU  - Ephrem G
AD  - Beth Israel Medical Center, Department of Medicine, New York City, NY 10003, USA.
      g.ephrem@gmail.com
LA  - eng
PT  - Journal Article
PL  - Lebanon
TA  - J Med Liban
JT  - Le Journal medical libanais. The Lebanese medical journal
JID - 0375352
RN  - 0 (Placebos)
SB  - IM
MH  - Controlled Clinical Trials as Topic/*ethics
MH  - Humans
MH  - Informed Consent
MH  - *Placebos
EDAT- 2012/08/28 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/08/28 06:00
PHST- 2012/08/28 06:00 [entrez]
PHST- 2012/08/28 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
PST - ppublish
SO  - J Med Liban. 2012 Apr-Jun;60(2):63-4.


PMID- 22919765
OWN - NLM
STAT- MEDLINE
DCOM- 20121010
LR  - 20180221
IS  - 1750-4589 (Print)
IS  - 1750-4589 (Linking)
VI  - 22
IP  - 7
DP  - 2012 Jul
TI  - Respect, compassion and dignity: the foundations of ethical and professional
      caring.
PG  - 216-9
AB  - Throughout 2011, and for much of this year, the national and professional press
      have been dominated by reports of failures in health and social care. Stories
      have focussed on the avoidable harm and disturbing cruelty suffered by
      individuals and the distress of distraught families seeking answers in the light 
      of systemic organisational failure on an incredible scale (Francis 2010, CQC
      2011a, CQC 2011b).
FAU - Reid, Jane
AU  - Reid J
AD  - Bournemouth University. janehreid@googlemail.com
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Perioper Pract
JT  - Journal of perioperative practice
JID - 101271023
MH  - *Empathy
MH  - Humans
MH  - Interprofessional Relations
MH  - *Organizational Culture
MH  - Patient Advocacy
MH  - Perioperative Care/*ethics
MH  - *Personhood
MH  - Professional-Family Relations/*ethics
MH  - United States
EDAT- 2012/08/28 06:00
MHDA- 2012/10/12 06:00
CRDT- 2012/08/28 06:00
PHST- 2012/08/28 06:00 [entrez]
PHST- 2012/08/28 06:00 [pubmed]
PHST- 2012/10/12 06:00 [medline]
AID - 10.1177/175045891202200701 [doi]
PST - ppublish
SO  - J Perioper Pract. 2012 Jul;22(7):216-9. doi: 10.1177/175045891202200701.


PMID- 22919450
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 0976-5123 (Electronic)
IS  - 1995-705X (Linking)
VI  - 13
IP  - 2
DP  - 2012 Apr
TI  - Vitamin e and omega-3: what to believe: observational studies or randomized
      controlled trials?
PG  - 66-8
LID - 10.4103/1995-705X.99230 [doi]
AB  - The practice of conventional medicine has markedly changed since the introduction
      of the concept of the evidence-based medicine. Randomized controlled study design
      and large sample size were the only justifications for level A or B evidence at
      the summit of what is called the evidence pyramid. A lot of medical interventions
      that were based on a plethora of basic researches and multiple large real world
      or observational studies in humans became questioned now by the results of even a
      single large sized randomized controlled trial (RCT). The conflicting evidences
      for the value of vitamin E and Omega-3 fatty acids in cardiovascular diseases are
      famous examples for such perplexity. This article discusses this problem on the
      basis of scientific, ethical, and statistical critical appraisal. To conclude, in
      this era of overwhelming flow of data, it should be emphasized in short,
      fast-to-read articles that it is important to consider not only the level of
      evidence "as dictated by the study design and sample size" but also the relevance
      of evidence. Studies tell us about populations but we treat individuals. The type
      of the studied individuals, the enrollment criteria, the methodology, the dose of
      the studied drug and all the combined medications in the study should be clearly 
      considered whenever the reported results are to be generalized beyond the
      specific situation studied. Comparing the effect of an active drug against
      placebo by giving either one of them to a group already treated with other
      multiple drugs (optimum medical therapy) could be a misleading indicator for the 
      pure efficacy of the active drug. Many confounding variables such as known "or
      unknown" drug-drug interactions, sharing mechanisms of action or unexpected
      adverse drug reactions can afflict only the group randomized to take the active
      drug. These variables will not affect the control group simply because they add
      to their optimized multiple drug therapy an inert placebo.
FAU - Yakoot, Mostafa
AU  - Yakoot M
AD  - Green Clinic and Research Centre, Alexandria, Egypt.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Heart Views
JT  - Heart views : the official journal of the Gulf Heart Association
JID - 101316474
PMC - PMC3424781
OTO - NOTNLM
OT  - Observational studies
OT  - Omega-3
OT  - randomized controlled trials
OT  - vitamin E
EDAT- 2012/08/25 06:00
MHDA- 2012/08/25 06:01
CRDT- 2012/08/25 06:00
PHST- 2012/08/25 06:00 [entrez]
PHST- 2012/08/25 06:00 [pubmed]
PHST- 2012/08/25 06:01 [medline]
AID - 10.4103/1995-705X.99230 [doi]
AID - HV-13-66 [pii]
PST - ppublish
SO  - Heart Views. 2012 Apr;13(2):66-8. doi: 10.4103/1995-705X.99230.


PMID- 22919378
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120824
LR  - 20211021
IS  - 1687-7071 (Electronic)
IS  - 1687-7063 (Linking)
VI  - 2012
DP  - 2012
TI  - Generativity as a route to active ageing.
PG  - 647650
LID - 10.1155/2012/647650 [doi]
AB  - We elucidate the significance of active ageing from an individual as well as from
      a societal perspective. Taking an individual perspective, maintaining activity in
      later years is linked to successful ageing because of empirical relationships to 
      positive self-perception, satisfaction with life, and development of competences,
      whereas from a societal perspective, active ageing implies usage of older
      people's life competences as a human capital of society-a societal imperative,
      particularly in times of demographic change but also more basically substantiated
      in an ethics of responsibility, intergenerational solidarity, and generation
      equity. We focus on the psychological construct of generativity which is
      interpreted as an aspect of the philosophical-anthropological category of joint
      responsibility. Our own research in Mexico and the Baltic States supports the
      notion that maintaining access to the public sphere and active engagement for
      others is a more basic individual concern than a life-stages specific
      developmental task. We report background and results of a Dialogue Forum Project 
      Funding, a research cooperation between our institute and the Foundation
      Remembrance, Responsibility, and Future aimed to improve generativity in Belarus,
      Russia, and Ukraine by implementing and supporting local initiatives offering
      opportunities for intergenerational dialogue.
FAU - Kruse, Andreas
AU  - Kruse A
AD  - Institute of Gerontology, Heidelberg University, 69115 Heidelberg, Germany.
FAU - Schmitt, Eric
AU  - Schmitt E
LA  - eng
PT  - Journal Article
DEP - 20120807
PL  - United States
TA  - Curr Gerontol Geriatr Res
JT  - Current gerontology and geriatrics research
JID - 101484307
PMC - PMC3420221
EDAT- 2012/08/25 06:00
MHDA- 2012/08/25 06:01
CRDT- 2012/08/25 06:00
PHST- 2012/05/16 00:00 [received]
PHST- 2012/06/19 00:00 [accepted]
PHST- 2012/08/25 06:00 [entrez]
PHST- 2012/08/25 06:00 [pubmed]
PHST- 2012/08/25 06:01 [medline]
AID - 10.1155/2012/647650 [doi]
PST - ppublish
SO  - Curr Gerontol Geriatr Res. 2012;2012:647650. doi: 10.1155/2012/647650. Epub 2012 
      Aug 7.


PMID- 22919140
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120824
LR  - 20211021
IS  - 1998-3824 (Electronic)
IS  - 0970-1591 (Linking)
VI  - 28
IP  - 2
DP  - 2012 Apr
TI  - Incidental solid renal mass in a cadaveric donor kidney.
PG  - 202-3
LID - 10.4103/0970-1591.98467 [doi]
AB  - The number of patients living with end-stage renal disease (ESRD) is increasing
      in our country and demand for renal grafts is ever increasing. Cadaver renal
      transplantation is being established as a viable supplement to live
      transplantation. We present a case where a mass lesion was encountered in the
      donor kidney from a cadaver. Enucleation of the lesion was done and we proceeded 
      with the grafting. Histopathological examination showed a 'Renomedullary
      interstitial cell tumour', a rare benign lesion. Post transplant, the renal
      function recovered well and the patient is asymptomatic. Such incidental renal
      masses present an ethical dilemma to the operating surgeon.
FAU - Meyyappan, R M
AU  - Meyyappan RM
AD  - Department of Urology, Madras Medical College, Chennai, India.
FAU - Rajaraman, T
AU  - Rajaraman T
FAU - Senthil, D
AU  - Senthil D
LA  - eng
PT  - Case Reports
PL  - India
TA  - Indian J Urol
JT  - Indian journal of urology : IJU : journal of the Urological Society of India
JID - 8510441
PMC - PMC3424901
OTO - NOTNLM
OT  - Benign renal mass
OT  - cadaver renal transplant
OT  - renomedullary interstitial cell tumour
EDAT- 2012/08/25 06:00
MHDA- 2012/08/25 06:01
CRDT- 2012/08/25 06:00
PHST- 2012/08/25 06:00 [entrez]
PHST- 2012/08/25 06:00 [pubmed]
PHST- 2012/08/25 06:01 [medline]
AID - 10.4103/0970-1591.98467 [doi]
AID - IJU-28-202 [pii]
PST - ppublish
SO  - Indian J Urol. 2012 Apr;28(2):202-3. doi: 10.4103/0970-1591.98467.


PMID- 22919131
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120824
LR  - 20211021
IS  - 1998-3824 (Electronic)
IS  - 0970-1591 (Linking)
VI  - 28
IP  - 2
DP  - 2012 Apr
TI  - Virtual cystoscopy (pneumo-cystoscopy)-Its utility in the prospective evaluation 
      of bladder tumor.
PG  - 164-8
LID - 10.4103/0970-1591.98457 [doi]
AB  - AIM: To evaluate the role of virtual cystoscopy (VC) comparing it with
      cystopanendoscopy (CPE) for detecting bladder tumor(s). MATERIAL AND METHODS:
      Ethical clearance was obtained from the Institutional ethics committee. After an 
      informed consent 30 patients fulfilling the inclusion criteria were enrolled in
      the prospective non-randomized clinical study and were evaluated as per protocol 
      with VC performed by a qualified radiologist who was blinded to the findings of
      CPE performed by a qualified urologist. The results so obtained were analyzed
      using appropriate statistical tools. RESULTS: The mean age of the patients was 56
      years. Sensitivity of VC in detecting bladder lesions was 92%. However, when
      axial images were also interpreted along with VC, the sensitivity increased to
      96% for detecting bladder lesions. The specificity of VC with axial CT was 40% in
      respect of detecting bladder lesions. VC with axial CT was 85.7% sensitive in
      identifying multiple bladder tumors. There were no complications on account of
      performing VC. Minor problems were encountered with VC and CPE in 16.7% and 13.3%
      patients respectively. CONCLUSIONS: VC with axial CT is 96% sensitive in
      detecting bladder lesions and 85.7% sensitive in detecting the multiplicity of
      the tumors. VC may be a useful complementary diagnostic tool for the workup of
      select patients with suspected bladder lesions. However, larger randomized
      controlled studies are needed to better define the precise clinical and
      diagnostic role of VC in routine practice. SETTINGS AND DESIGN: Prospective
      Clinical Comparative Non Randomized Clinical Study.
FAU - Singh, Iqbal
AU  - Singh I
AD  - Department of Surgery (Div of Urology), University College of Medical Sciences
      (University of Delhi) and GTB Hospital, Delhi, India.
FAU - Mehrotra, Gopesh
AU  - Mehrotra G
FAU - Jaura, Maninder S
AU  - Jaura MS
FAU - Agarwal, Vivek
AU  - Agarwal V
FAU - Tandon, Anupama
AU  - Tandon A
FAU - Joshi, Mohit
AU  - Joshi M
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Urol
JT  - Indian journal of urology : IJU : journal of the Urological Society of India
JID - 8510441
PMC - PMC3424892
OTO - NOTNLM
OT  - Bladder tumor
OT  - cystopanendoscopy
OT  - pneumocystoscopy
OT  - virtual cystoscopy
EDAT- 2012/08/25 06:00
MHDA- 2012/08/25 06:01
CRDT- 2012/08/25 06:00
PHST- 2012/08/25 06:00 [entrez]
PHST- 2012/08/25 06:00 [pubmed]
PHST- 2012/08/25 06:01 [medline]
AID - 10.4103/0970-1591.98457 [doi]
AID - IJU-28-164 [pii]
PST - ppublish
SO  - Indian J Urol. 2012 Apr;28(2):164-8. doi: 10.4103/0970-1591.98457.


PMID- 22919041
OWN - NLM
STAT- MEDLINE
DCOM- 20121129
LR  - 20220316
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 264
IP  - 3
DP  - 2012 Sep
TI  - Evaluation of rotator cuff tendon tears: comparison of multidetector CT
      arthrography and 1.5-T MR arthrography.
PG  - 812-22
LID - 10.1148/radiol.12112062 [doi]
AB  - PURPOSE: To compare the diagnostic performance of multidetector computed
      tomographic (CT) arthrography and 1.5-T magnetic resonance (MR) arthrography in
      the evaluation of rotator cuff lesions, with arthroscopic correlation. MATERIALS 
      AND METHODS: This study was approved by the institutional ethical committee, and 
      informed consent was obtained from all patients. CT and MR arthrographic images
      prospectively obtained in 56 consecutive patients, following the same
      arthrographic procedure, were independently evaluated by two radiologists.
      Arthroscopy, performed within 1 month of the imaging, was used as the reference
      standard. Sensitivity and specificity of CT and MR arthrography were compared by 
      using the McNemar test. Interobserver and intertechnique agreement for detecting 
      rotator cuff lesions were measured and compared with kappa and Z statistics. The 
      Bland-Altman method was used to determine interobserver and intertechnique
      agreement for measuring tendon tears. For grading fatty infiltration of rotator
      cuff muscles, kappa and Z statistics were used. RESULTS: There was no
      statistically significant difference in sensitivity and specificity between CT
      arthrography and MR arthrography in depiction of rotator cuff lesions. The
      respective sensitivity and specificity of CT arthrography were 92% and 93%-97%
      for the supraspinatus, 100% and 77%-79% for the infraspinatus, 75%-88% and
      85%-90% for the subscapularis, and 55%-65% and 100% for the biceps tendon. The
      respective sensitivity and specificity of MR arthrography were 96% and 83%-93%
      for the supraspinatus, 88%-100% and 81%-83% for the infraspinatus, 75%-88% and
      90%-100% for the subscapularis, and 65%-85% and 100% for the biceps tendon.
      Interobserver agreement was substantial to almost perfect (kappa = 0.744-0.964
      for CT arthrography; kappa = 0.641-0.893 for MR arthrography), and intertechnique
      agreement was almost perfect (kappa > 0.819). CT and MR arthrography both yielded
      moderate interobserver and intertechnique agreement for measuring rotator cuff
      tears and grading muscle fatty infiltration. CONCLUSION: Data suggest that CT and
      MR arthrography have similar diagnostic performance for the evaluation of rotator
      cuff tendon tears.
CI  - (c) RSNA, 2012
FAU - Omoumi, Patrick
AU  - Omoumi P
AD  - Department of Radiology, Saint-Luc University Hospital-UC Louvain, Hippocrate
      Avenue 10/2942, B-1200 Brussels, Belgium. patrick.omoumi@uclouvain.be
FAU - Bafort, Anne-Catherine
AU  - Bafort AC
FAU - Dubuc, Jean-Emile
AU  - Dubuc JE
FAU - Malghem, Jacques
AU  - Malghem J
FAU - Vande Berg, Bruno C
AU  - Vande Berg BC
FAU - Lecouvet, Frederic E
AU  - Lecouvet FE
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
CIN - Rofo. 2013 Apr;185(4):305. PMID: 23553387
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Arthrography/*methods
MH  - Arthroscopy
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - *Rotator Cuff Injuries
MH  - Sensitivity and Specificity
MH  - Tendon Injuries/*diagnosis/diagnostic imaging
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2012/08/25 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/08/25 06:00
PHST- 2012/08/25 06:00 [entrez]
PHST- 2012/08/25 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 264/3/812 [pii]
AID - 10.1148/radiol.12112062 [doi]
PST - ppublish
SO  - Radiology. 2012 Sep;264(3):812-22. doi: 10.1148/radiol.12112062.


PMID- 22918990
OWN - NLM
STAT- MEDLINE
DCOM- 20130416
LR  - 20211021
IS  - 1537-6591 (Electronic)
IS  - 1058-4838 (Linking)
VI  - 55
IP  - 11
DP  - 2012 Dec
TI  - The ethics of testing a test: randomized trials of the health impact of
      diagnostic tests for infectious diseases.
PG  - 1522-6
LID - 10.1093/cid/cis736 [doi]
AB  - In the last decade, many new rapid diagnostic tests for infectious diseases have 
      been developed. In general, these new tests are developed with the intent to
      optimize feasibility and population health, not accuracy alone. However, unlike
      drugs or vaccines, diagnostic tests are evaluated and licensed on the basis of
      accuracy, not health impact (eg, reduced morbidity or mortality). Thus, these
      tests are sometimes recommended or scaled up for purposes of improving population
      health without randomized evidence that they do so. We highlight the importance
      of randomized trials to evaluate the health impact of novel diagnostics and note 
      that such trials raise distinctive ethical challenges of equipoise, equity, and
      informed consent. We discuss the distinction between equipoise for
      patient-important outcomes versus diagnostic accuracy, the equity implications of
      evaluating health impact of diagnostics under routine conditions, and the
      importance of offering reasonable choices for informed consent in diagnostic
      trials.
FAU - Dowdy, David W
AU  - Dowdy DW
AD  - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health,
      Johns Hopkins University, Baltimore, Maryland, USA. ddowdy@jhsph.edu
FAU - Gounder, Celine R
AU  - Gounder CR
FAU - Corbett, Elizabeth L
AU  - Corbett EL
FAU - Ngwira, Lucky G
AU  - Ngwira LG
FAU - Chaisson, Richard E
AU  - Chaisson RE
FAU - Merritt, Maria W
AU  - Merritt MW
LA  - eng
GR  - 091769/Wellcome Trust/United Kingdom
GR  - P30 AI094189/AI/NIAID NIH HHS/United States
GR  - R01 AI093316/AI/NIAID NIH HHS/United States
GR  - 1P30AI094189-01A1/AI/NIAID NIH HHS/United States
GR  - R01 AI093316-01A1/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120823
PL  - United States
TA  - Clin Infect Dis
JT  - Clinical infectious diseases : an official publication of the Infectious Diseases
      Society of America
JID - 9203213
SB  - IM
MH  - Communicable Diseases/*diagnosis
MH  - Diagnostic Tests, Routine/*ethics/*methods
MH  - *Ethics, Research
MH  - Humans
MH  - *Informed Consent
MH  - Randomized Controlled Trials as Topic/*ethics/*methods
MH  - *Reproducibility of Results
PMC - PMC3491859
EDAT- 2012/08/25 06:00
MHDA- 2013/04/17 06:00
CRDT- 2012/08/25 06:00
PHST- 2012/08/25 06:00 [entrez]
PHST- 2012/08/25 06:00 [pubmed]
PHST- 2013/04/17 06:00 [medline]
AID - cis736 [pii]
AID - 10.1093/cid/cis736 [doi]
PST - ppublish
SO  - Clin Infect Dis. 2012 Dec;55(11):1522-6. doi: 10.1093/cid/cis736. Epub 2012 Aug
      23.


PMID- 22918138
OWN - NLM
STAT- MEDLINE
DCOM- 20130228
LR  - 20220409
IS  - 1943-7811 (Electronic)
IS  - 1525-1578 (Linking)
VI  - 14
IP  - 6
DP  - 2012 Nov
TI  - Opportunities and challenges associated with clinical diagnostic genome
      sequencing: a report of the Association for Molecular Pathology.
PG  - 525-40
LID - 10.1016/j.jmoldx.2012.04.006 [doi]
LID - S1525-1578(12)00175-4 [pii]
AB  - This report of the Whole Genome Analysis group of the Association for Molecular
      Pathology illuminates the opportunities and challenges associated with clinical
      diagnostic genome sequencing. With the reality of clinical application of
      next-generation sequencing, technical aspects of molecular testing can be
      accomplished at greater speed and with higher volume, while much information is
      obtained. Although this testing is a next logical step for molecular pathology
      laboratories, the potential impact on the diagnostic process and clinical
      correlations is extraordinary and clinical interpretation will be challenging. We
      review the rapidly evolving technologies; provide application examples; discuss
      aspects of clinical utility, ethics, and consent; and address the analytic,
      postanalytic, and professional implications.
CI  - Copyright (c) 2012 American Society for Investigative Pathology and the
      Association for Molecular Pathology. Published by Elsevier Inc. All rights
      reserved.
FAU - Schrijver, Iris
AU  - Schrijver I
AD  - Whole Genome Analysis Working Group, Association for Molecular Pathology Clinical
      Practice Committee, Bethesda, Maryland, USA. ischrijver@stanfordmed.org
FAU - Aziz, Nazneen
AU  - Aziz N
FAU - Farkas, Daniel H
AU  - Farkas DH
FAU - Furtado, Manohar
AU  - Furtado M
FAU - Gonzalez, Andrea Ferreira
AU  - Gonzalez AF
FAU - Greiner, Timothy C
AU  - Greiner TC
FAU - Grody, Wayne W
AU  - Grody WW
FAU - Hambuch, Tina
AU  - Hambuch T
FAU - Kalman, Lisa
AU  - Kalman L
FAU - Kant, Jeffrey A
AU  - Kant JA
FAU - Klein, Roger D
AU  - Klein RD
FAU - Leonard, Debra G B
AU  - Leonard DG
FAU - Lubin, Ira M
AU  - Lubin IM
FAU - Mao, Rong
AU  - Mao R
FAU - Nagan, Narasimhan
AU  - Nagan N
FAU - Pratt, Victoria M
AU  - Pratt VM
FAU - Sobel, Mark E
AU  - Sobel ME
FAU - Voelkerding, Karl V
AU  - Voelkerding KV
FAU - Gibson, Jane S
AU  - Gibson JS
LA  - eng
GR  - CC999999/Intramural CDC HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120820
PL  - United States
TA  - J Mol Diagn
JT  - The Journal of molecular diagnostics : JMD
JID - 100893612
SB  - IM
MH  - Computational Biology/methods
MH  - *Genome, Human
MH  - Genomics/education
MH  - High-Throughput Nucleotide Sequencing/economics/*methods
MH  - Humans
MH  - Neoplasms/diagnosis/economics/genetics
MH  - Patents as Topic
MH  - Pathology, Molecular/economics/*methods
MH  - Validation Studies as Topic
PMC - PMC6504171
MID - NIHMS837941
EDAT- 2012/08/25 06:00
MHDA- 2013/03/01 06:00
CRDT- 2012/08/25 06:00
PHST- 2012/02/29 00:00 [received]
PHST- 2012/04/12 00:00 [revised]
PHST- 2012/04/19 00:00 [accepted]
PHST- 2012/08/25 06:00 [entrez]
PHST- 2012/08/25 06:00 [pubmed]
PHST- 2013/03/01 06:00 [medline]
AID - S1525-1578(12)00175-4 [pii]
AID - 10.1016/j.jmoldx.2012.04.006 [doi]
PST - ppublish
SO  - J Mol Diagn. 2012 Nov;14(6):525-40. doi: 10.1016/j.jmoldx.2012.04.006. Epub 2012 
      Aug 20.


PMID- 22918063
OWN - NLM
STAT- MEDLINE
DCOM- 20130522
LR  - 20181202
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 20
IP  - 1
DP  - 2013 Feb
TI  - Time ethics for persons with dementia in care homes.
PG  - 51-60
LID - 10.1177/0969733012448968 [doi]
AB  - The purpose of this study was to explore situations experienced by 12 health-care
      providers working in two nursing homes. Individual interviews, using a narrative 
      approach, were conducted. A phenomenological-hermeneutical method, developed for 
      researching life experiences, was applied in the analysis. The findings showed
      that good care situations are experienced when the time culture is flexible, the 
      carers act in a sovereign time rhythm, not mentioning clock time or time as a
      stress factor. The results are discussed in terms of anthropological and
      sociological theory: time as event and action and flexible time cultures. Care
      settings for persons with dementia represent many challenges, such as a heavy
      workload and time strain. Time ethics is a construction, understanding time used 
      in caring for persons suffering from dementia, which involves a mature,
      responsible and flexible nursing approach to these patients.
FAU - Egede-Nissen, Veslemoy
AU  - Egede-Nissen V
AD  - Lovisenberg Diaconal University College, Norway. Veslemoy.egede-nissen@ldh.no
FAU - Jakobsen, Rita
AU  - Jakobsen R
FAU - Sellevold, Gerd S
AU  - Sellevold GS
FAU - Sorlie, Venke
AU  - Sorlie V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120822
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Dementia/*nursing
MH  - Humans
MH  - Interviews as Topic
MH  - *Nursing Homes
MH  - Organizational Culture
MH  - *Physician-Patient Relations
MH  - Physicians/*psychology
MH  - *Time Management
MH  - Workforce
MH  - Workload
EDAT- 2012/08/25 06:00
MHDA- 2013/05/23 06:00
CRDT- 2012/08/25 06:00
PHST- 2012/08/25 06:00 [entrez]
PHST- 2012/08/25 06:00 [pubmed]
PHST- 2013/05/23 06:00 [medline]
AID - 0969733012448968 [pii]
AID - 10.1177/0969733012448968 [doi]
PST - ppublish
SO  - Nurs Ethics. 2013 Feb;20(1):51-60. doi: 10.1177/0969733012448968. Epub 2012 Aug
      22.


PMID- 22918061
OWN - NLM
STAT- MEDLINE
DCOM- 20130522
LR  - 20220309
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 20
IP  - 1
DP  - 2013 Feb
TI  - Ethical challenges and how to develop ethics support in primary health care.
PG  - 96-108
LID - 10.1177/0969733012452687 [doi]
AB  - Ethics support in primary health care has been sparser than in hospitals, the
      need for ethics support is probably no less. We have, however, limited knowledge 
      about how to develop ethics support that responds to primary health-care workers'
      needs. In this article, we present a survey with a mixture of closed- and
      open-ended questions concerning: How frequent and how distressed various types of
      ethical challenges make the primary health-care workers feel, how important they 
      think it is to deal with these challenges better and what kind of ethics support 
      they want. Five primary health-care institutions participated. Ethical challenges
      seem to be prominent and common. Most frequently, the participants experienced
      ethical challenges related to scarce resources and lack of knowledge and skills. 
      Furthermore, ethical challenges related to communication and decision making were
      common. The participants welcomed ethics support responding to their challenges
      and being integrated in their daily practices.
FAU - Lillemoen, Lillian
AU  - Lillemoen L
AD  - Centre for Medical Ethics, University of Oslo, Oslo, Norway.
      lillian.lillemoen@medisin.uio.no
FAU - Pedersen, Reidar
AU  - Pedersen R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120822
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - *Health Knowledge, Attitudes, Practice
MH  - Health Personnel/*psychology
MH  - Humans
MH  - Nursing Research
MH  - Primary Health Care/*ethics
MH  - *Social Support
MH  - Stress, Psychological
MH  - Surveys and Questionnaires
EDAT- 2012/08/25 06:00
MHDA- 2013/05/23 06:00
CRDT- 2012/08/25 06:00
PHST- 2012/08/25 06:00 [entrez]
PHST- 2012/08/25 06:00 [pubmed]
PHST- 2013/05/23 06:00 [medline]
AID - 0969733012452687 [pii]
AID - 10.1177/0969733012452687 [doi]
PST - ppublish
SO  - Nurs Ethics. 2013 Feb;20(1):96-108. doi: 10.1177/0969733012452687. Epub 2012 Aug 
      22.


PMID- 22918059
OWN - NLM
STAT- MEDLINE
DCOM- 20130522
LR  - 20181202
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 20
IP  - 1
DP  - 2013 Feb
TI  - Ethical issues experienced by intensive care unit nurses in everyday practice.
PG  - 72-82
LID - 10.1177/0969733012452683 [doi]
AB  - This research aims to identify the ethical issues perceived by intensive care
      nurses in their everyday practice. It also aims to understand why these
      situations were considered an ethical issue and what interventions/strategies
      have been or are expected to be developed so as to minimize them. Data were
      collected using a semi-structured interview with 15 nurses working at polyvalent 
      intensive care units in 4 Portuguese hospitals, who were selected by the
      homogenization of multiple samples. The qualitative content analysis identified
      end-of-life decisions, privacy, interaction, team work, and health-care access as
      emerging ethical issues. Personal, team, and institutional aspects emerge as
      reasons behind the experience of these issues. Personal and team resources are
      used in and for solving these issues. Moral development and training are the most
      significant strategies.
FAU - Fernandes, Maria I D
AU  - Fernandes MI
AD  - Department of Medical-Surgical Nursing, Nursing School of Coimbra, Portugal.
      isabelf@esenfc.pt
FAU - Moreira, Isabel M P B
AU  - Moreira IM
LA  - eng
PT  - Journal Article
DEP - 20120822
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - *Ethics, Nursing
MH  - Health Services Accessibility/standards
MH  - Humans
MH  - Intensive Care Units
MH  - Interviews as Topic
MH  - *Nurse-Patient Relations
MH  - Patient Care Team
MH  - Portugal
MH  - Privacy
MH  - Qualitative Research
MH  - *Social Support
MH  - Staff Development
MH  - Terminal Care/*psychology
MH  - Workforce
EDAT- 2012/08/25 06:00
MHDA- 2013/05/23 06:00
CRDT- 2012/08/25 06:00
PHST- 2012/08/25 06:00 [entrez]
PHST- 2012/08/25 06:00 [pubmed]
PHST- 2013/05/23 06:00 [medline]
AID - 0969733012452683 [pii]
AID - 10.1177/0969733012452683 [doi]
PST - ppublish
SO  - Nurs Ethics. 2013 Feb;20(1):72-82. doi: 10.1177/0969733012452683. Epub 2012 Aug
      22.


PMID- 22918058
OWN - NLM
STAT- MEDLINE
DCOM- 20150909
LR  - 20130913
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 20
IP  - 6
DP  - 2013 Sep
TI  - Exploring ethical aspects of elective surgery patients' decision-making
      experiences.
PG  - 672-83
LID - 10.1177/0969733012448967 [doi]
AB  - The practice of respecting patients' autonomy is rooted in the healthcare
      professionals' empathy for patients' situations, without which appropriate
      supports to the patients during the informed consent process may be remarkably
      moderated. The purpose of this study was to explore elective surgery patients'
      experiences during their decision-making process. This research was conducted
      using a phenomenological approach, and the data analysis was guided by Colaizzi's
      method. A total of 17 participants were recruited from a hospital in southern
      Taiwan. Two major themes emerged from the analyses: (a) a voluntary yet necessary
      alternative--to undergo a surgery and (b) alternatives compelled by the
      unalterable decision--the surgery. It was concluded that unless healthcare
      professionals can empathize with the distressed situation of their patients who
      are facing elective surgery, the practice of informed consent may become merely a
      routine. Nurses can be the best advocates for patients and facilitators to
      enhance communication between patients and healthcare personnel.
FAU - Lin, Mei-Ling
AU  - Lin ML
AD  - National Cheng Kung University, Taiwan; National Changhua University of
      Education, Taiwan.
FAU - Huang, Chuen-Teng
AU  - Huang CT
FAU - Chiang, Hsien-Hsien
AU  - Chiang HH
FAU - Chen, Ching-Huey
AU  - Chen CH
LA  - eng
PT  - Journal Article
DEP - 20120822
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Adult
MH  - Decision Making/*ethics
MH  - Elective Surgical Procedures/*ethics/psychology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Patient Advocacy/*ethics
MH  - Patient Rights/*ethics
MH  - Patient-Centered Care/*ethics
MH  - Professional-Patient Relations/*ethics
MH  - Quality Assurance, Health Care/ethics
MH  - Taiwan
OTO - NOTNLM
OT  - Decision-making
OT  - doctors
OT  - elective surgery
OT  - ethics
OT  - nurses
OT  - patient experience
EDAT- 2012/08/25 06:00
MHDA- 2015/09/10 06:00
CRDT- 2012/08/25 06:00
PHST- 2012/08/25 06:00 [entrez]
PHST- 2012/08/25 06:00 [pubmed]
PHST- 2015/09/10 06:00 [medline]
AID - 0969733012448967 [pii]
AID - 10.1177/0969733012448967 [doi]
PST - ppublish
SO  - Nurs Ethics. 2013 Sep;20(6):672-83. doi: 10.1177/0969733012448967. Epub 2012 Aug 
      22.


PMID- 22918057
OWN - NLM
STAT- MEDLINE
DCOM- 20130522
LR  - 20130307
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 20
IP  - 2
DP  - 2013 Mar
TI  - Ethical aspects of undergoing a predictive genetic testing for Huntington's
      disease.
PG  - 189-99
LID - 10.1177/0969733012452686 [doi]
AB  - The aim of this study was to describe the experiences of undergoing a
      presymptomatic genetic test for the hereditary and fatal Huntington's disease,
      using a case study approach. The study was based on 18 interviews with a young
      woman and her husband from the decision to undergo the test, to receiving the
      results and trying to adapt to them, which were analysed using a life history
      approach. The findings show that the process of undergoing a presymptomatic test 
      involves several closely connected ethical and medical questions, such as the
      reason for the test, the consequences of the test results and how health-care
      services can be developed to support people in this situation.
FAU - Andersson, Petra Lilja
AU  - Andersson PL
AD  - Division of Nursing, Department of Health Sciences, Lund University, P.O. Box
      157, SE-221 00 Lund, Sweden. Petra.lilja_andersson@med.lu.se
FAU - Juth, Niklas
AU  - Juth N
FAU - Petersen, Asa
AU  - Petersen A
FAU - Graff, Caroline
AU  - Graff C
FAU - Edberg, Anna-Karin
AU  - Edberg AK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120822
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - *Ethics, Nursing
MH  - Female
MH  - Genetic Testing/*ethics
MH  - Humans
MH  - *Huntington Disease
EDAT- 2012/08/25 06:00
MHDA- 2013/05/23 06:00
CRDT- 2012/08/25 06:00
PHST- 2012/08/25 06:00 [entrez]
PHST- 2012/08/25 06:00 [pubmed]
PHST- 2013/05/23 06:00 [medline]
AID - 0969733012452686 [pii]
AID - 10.1177/0969733012452686 [doi]
PST - ppublish
SO  - Nurs Ethics. 2013 Mar;20(2):189-99. doi: 10.1177/0969733012452686. Epub 2012 Aug 
      22.


PMID- 22918056
OWN - NLM
STAT- MEDLINE
DCOM- 20130522
LR  - 20151119
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 20
IP  - 1
DP  - 2013 Feb
TI  - Decisions of psychiatric nurses about duty to warn, compulsory hospitalization,
      and competence of patients.
PG  - 41-50
LID - 10.1177/0969733012448953 [doi]
AB  - Nurses who attend patients with psychiatric disorders often encounter ethical
      dilemmas and experience difficulties in making the right decision. The present
      study aimed to evaluate the decisions of psychiatric nurses regarding their duty 
      to warn third parties about the dangerousness of the patient, the need for
      compulsory hospitalization, and the competence of patients. In total, 111 nurses 
      working in the field of psychiatry in Turkey completed a questionnaire form
      consisting of 33 questions. The nurses generally assessed the decision-making
      competency of the patient correctly. However, their decisions regarding whether
      the patient should be compulsorily hospitalized and their understanding of their 
      duty to warn/protect were less consistent. A significant relationship was found
      between the decisions of the psychiatric nurses and their work experience, them
      having children, and them having postgraduate education in psychiatric nursing.
      The nurses stated their desire to be part of the team that decided on ethical
      problems in psychiatry.
FAU - Sehiralti, Mine
AU  - Sehiralti M
AD  - Department of History of Medicine and Medical Ethics, Faculty of Medicine,
      Kocaeli University, Kocaeli, Turkey. msehir@gmail.com
FAU - Er, Rahime A
AU  - Er RA
LA  - eng
PT  - Journal Article
DEP - 20120822
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - *Commitment of Mentally Ill
MH  - Duty to Warn/*ethics/psychology
MH  - Family Relations
MH  - Hospitals, Psychiatric
MH  - Humans
MH  - *Mental Competency
MH  - Mental Disorders/therapy
MH  - Psychiatric Nursing/education/*ethics
MH  - Surveys and Questionnaires
MH  - Turkey
EDAT- 2012/08/25 06:00
MHDA- 2013/05/23 06:00
CRDT- 2012/08/25 06:00
PHST- 2012/08/25 06:00 [entrez]
PHST- 2012/08/25 06:00 [pubmed]
PHST- 2013/05/23 06:00 [medline]
AID - 0969733012448953 [pii]
AID - 10.1177/0969733012448953 [doi]
PST - ppublish
SO  - Nurs Ethics. 2013 Feb;20(1):41-50. doi: 10.1177/0969733012448953. Epub 2012 Aug
      22.


PMID- 22918055
OWN - NLM
STAT- MEDLINE
DCOM- 20130522
LR  - 20191210
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 20
IP  - 1
DP  - 2013 Feb
TI  - Ethical issues in the introduction of case management for elderly people.
PG  - 83-95
LID - 10.1177/0969733012452685 [doi]
AB  - As case management is under development in France for elderly people, this study 
      sets out to identify and analyse key situations responsible for ethical dilemmas 
      for French case managers. We based our study on the analyses of individual
      interviews made with case managers and focus-group discussions, bringing together
      all case managers working in local organisations running for at least a year. We 
      identified three situations giving rise to ethical dilemmas: in the order of
      importance, the refusals of care, the practicalities of collecting and sharing
      personal data and the allocation of resources. These three situations can lead to
      conflict between the principle of beneficence and those of respect for autonomy, 
      non-maleficence and justice. We describe here how French case managers
      practically deal with these situations.
FAU - Corvol, Aline
AU  - Corvol A
AD  - Universite Paris Descartes, France. aline.corvol@dzne.de
FAU - Moutel, Gregoire
AU  - Moutel G
FAU - Gagnon, Dominique
AU  - Gagnon D
FAU - Nugue, Mathilde
AU  - Nugue M
FAU - Saint-Jean, Olivier
AU  - Saint-Jean O
FAU - Somme, Dominique
AU  - Somme D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120822
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Administrative Personnel/*psychology
MH  - Case Management/*ethics
MH  - Conflict, Psychological
MH  - Focus Groups
MH  - France
MH  - *Health Services for the Aged
MH  - Humans
MH  - Interviews as Topic
MH  - Outcome and Process Assessment, Health Care/*ethics/methods
MH  - Resource Allocation
MH  - Treatment Refusal
EDAT- 2012/08/25 06:00
MHDA- 2013/05/23 06:00
CRDT- 2012/08/25 06:00
PHST- 2012/08/25 06:00 [entrez]
PHST- 2012/08/25 06:00 [pubmed]
PHST- 2013/05/23 06:00 [medline]
AID - 0969733012452685 [pii]
AID - 10.1177/0969733012452685 [doi]
PST - ppublish
SO  - Nurs Ethics. 2013 Feb;20(1):83-95. doi: 10.1177/0969733012452685. Epub 2012 Aug
      22.


PMID- 22917983
OWN - NLM
STAT- MEDLINE
DCOM- 20131223
LR  - 20181202
IS  - 1873-7862 (Electronic)
IS  - 0924-977X (Linking)
VI  - 23
IP  - 6
DP  - 2013 Jun
TI  - Long-term efficacy and safety of treatment with stimulants and atomoxetine in
      adult ADHD: a review of controlled and naturalistic studies.
PG  - 508-27
LID - 10.1016/j.euroneuro.2012.07.016 [doi]
LID - S0924-977X(12)00198-8 [pii]
AB  - Attention-deficit/hyperactivity disorder (ADHD) is a common disorder of childhood
      that often persists into adulthood. Although stimulant medications are
      recommended as the first-line treatment for ADHD because of their documented
      short-term effects in children and adults, less is known about their effects on
      long-term outcome in adults. Here we review the long-term efficacy and safety of 
      the stimulant drugs methylphenidate and amphetamine, as well as the related
      compound atomoxetine. We performed a systematic review to identify direct and
      indirect effects of stimulant therapy on long-term outcome in adults. Five
      randomized controlled trials (RCTs), and 10 open-label extension studies of
      initial short-term RCTs, with total follow-up of at least 24weeks, were
      identified. All these RCTs found that medication was significantly more
      efficacious than placebo in treating ADHD in adults, and the extension studies
      showed that this favorable effect of medication was maintained during the
      open-label follow-up period. However, since the maximum duration of these
      pharmacological trials was 4years, we also reviewed 18 defined naturalistic
      longitudinal and cross-sectional studies, to provide more information about
      longer term functional outcomes, side effects and complications. These
      observational studies also showed positive correlations between early recognition
      of the disorder, stimulant treatment during childhood and favorable long-term
      outcome in adult ADHD patients. In conclusion, stimulant therapy of ADHD has
      long-term beneficial effects and is well tolerated. However, more longitudinal
      studies of long duration should be performed. In addition, the ethical issues
      involved in performing double blind RCTs of many years duration should be further
      explored.
CI  - Copyright (c) 2012 Elsevier B.V. and ECNP. All rights reserved.
FAU - Fredriksen, Mats
AU  - Fredriksen M
AD  - Division of Mental Health & Addiction, Vestfold Hospital Trust, Norway.
FAU - Halmoy, Anne
AU  - Halmoy A
FAU - Faraone, Stephen V
AU  - Faraone SV
FAU - Haavik, Jan
AU  - Haavik J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20120820
PL  - Netherlands
TA  - Eur Neuropsychopharmacol
JT  - European neuropsychopharmacology : the journal of the European College of
      Neuropsychopharmacology
JID - 9111390
RN  - 0 (Adrenergic Uptake Inhibitors)
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Propylamines)
RN  - 207ZZ9QZ49 (Methylphenidate)
RN  - 57WVB6I2W0 (Atomoxetine Hydrochloride)
RN  - CK833KGX7E (Amphetamine)
SB  - IM
MH  - Adrenergic Uptake Inhibitors/adverse effects/*therapeutic use
MH  - Adult
MH  - Amphetamine/adverse effects/therapeutic use
MH  - Atomoxetine Hydrochloride
MH  - Attention Deficit Disorder with Hyperactivity/*drug therapy
MH  - Central Nervous System Stimulants/adverse effects/*therapeutic use
MH  - Cross-Sectional Studies
MH  - Humans
MH  - Longitudinal Studies
MH  - Methylphenidate/adverse effects/therapeutic use
MH  - Propylamines/adverse effects/*therapeutic use
MH  - Randomized Controlled Trials as Topic
EDAT- 2012/08/25 06:00
MHDA- 2013/12/24 06:00
CRDT- 2012/08/25 06:00
PHST- 2012/02/25 00:00 [received]
PHST- 2012/06/28 00:00 [revised]
PHST- 2012/07/24 00:00 [accepted]
PHST- 2012/08/25 06:00 [entrez]
PHST- 2012/08/25 06:00 [pubmed]
PHST- 2013/12/24 06:00 [medline]
AID - S0924-977X(12)00198-8 [pii]
AID - 10.1016/j.euroneuro.2012.07.016 [doi]
PST - ppublish
SO  - Eur Neuropsychopharmacol. 2013 Jun;23(6):508-27. doi:
      10.1016/j.euroneuro.2012.07.016. Epub 2012 Aug 20.


PMID- 22917936
OWN - NLM
STAT- MEDLINE
DCOM- 20130422
LR  - 20161125
IS  - 1872-7654 (Electronic)
IS  - 0301-2115 (Linking)
VI  - 165
IP  - 1
DP  - 2012 Nov
TI  - A multicentre prospective randomised study of single-incision mini-sling
      (Ajust(R)) versus tension-free vaginal tape-obturator (TVT-O) in the management
      of female stress urinary incontinence: pain profile and short-term outcomes.
PG  - 115-21
LID - 10.1016/j.ejogrb.2012.06.022 [doi]
LID - S0301-2115(12)00289-8 [pii]
AB  - OBJECTIVES: To compare the postoperative pain profile, peri-operative details,
      and short-term patient-reported and objective success rates of single-incision
      mini-slings (SIMS) versus standard mid-urethral slings (SMUS). STUDY DESIGN: In a
      multicentre prospective randomised trial in six UK centres in the period between 
      October 2009 and October 2010, 137 women were randomised to either adjustable
      SIMS (Ajust(R), C. R. Bard Inc., NJ, USA), performed under local anaesthesia as
      an opt-out policy (n=69), or SMUS (TVT-O, Ethicon Inc., Somerville, USA)
      performed under general anaesthesia (n=68). Randomisation was done through
      number-allocation software and using telephone randomisation. Postoperative pain 
      profile (primary outcome) was assessed on a ten-point visual analogue scale at
      fixed time-points. Pre- and post operatively (4-6 months) women completed symptom
      severity, urgency perception scale (UPS), quality of life and sexual function
      questionnaires. In addition, women completed a Patient Global Impression of
      Improvement Questionnaire and underwent a cough stress test at 4-6 months follow 
      up. Sample size calculation was performed and data were analysed using SPSS 18.
      Descriptive analyses are given and between-group comparisons were performed using
      chi-square, Fischer exact test and Mann-Whitney test as appropriate. Significance
      level was set at 5%. RESULTS: Women in the SIMS Ajust(R) group had a
      significantly lower postoperative pain profile up to 4 weeks (p=<0.001, 95% CI
      1.151, 2.480). There was no significant difference in peri-operative
      complications between groups. All 137 women completed the 4-6 months follow-up.
      Patient-reported and objective cure rates were not significantly different: 85.5%
      versus 91.2% (p=0.443) and 90% versus 97% (p=0.165) between the SIMS Ajust(R) and
      TVT-O groups respectively. There was a trend towards higher rates of de novo
      urgency or worsening of pre-existing urgency in the SIMS Ajust(R) group (21.7%
      versus 8.8%) but this did not reach statistical significance (p=0.063). Women in 
      the SIMS Ajust(R) group had shorter hospital stay (median (IQR) 3.65 (2.49,
      4.96)) compared to (4.42 (3.16, 5.56)) the TVT-O group 95% CI (-0.026, 1.326),
      with significantly earlier return to normal activities (p=0.025) and to work
      (p=0.006). CONCLUSION: The adjustable single-incision mini-sling (Ajust(R)) is
      associated with a significantly improved postoperative pain profile and earlier
      return to work when compared to standard mid-urethral slings (TVT-O), with
      encouraging results in patient-reported and objective success rates at short-term
      follow-up.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Mostafa, Alyaa
AU  - Mostafa A
AD  - University of Aberdeen, Aberdeen, United Kingdom.
FAU - Agur, Wael
AU  - Agur W
FAU - Abdel-All, Mohamed
AU  - Abdel-All M
FAU - Guerrero, Karen
AU  - Guerrero K
FAU - Lim, Chi
AU  - Lim C
FAU - Allam, Mohamed
AU  - Allam M
FAU - Yousef, Mohamed
AU  - Yousef M
FAU - N'Dow, James
AU  - N'Dow J
FAU - Abdel-fattah, Mohamed
AU  - Abdel-fattah M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20120820
PL  - Ireland
TA  - Eur J Obstet Gynecol Reprod Biol
JT  - European journal of obstetrics, gynecology, and reproductive biology
JID - 0375672
SB  - IM
MH  - Activities of Daily Living
MH  - Adult
MH  - Cohort Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Intention to Treat Analysis
MH  - Length of Stay
MH  - Middle Aged
MH  - Pain Measurement
MH  - Pain, Postoperative/*prevention & control
MH  - Perioperative Period
MH  - Quality of Life
MH  - Remission Induction
MH  - Severity of Illness Index
MH  - Sexual Behavior
MH  - *Suburethral Slings/adverse effects
MH  - United Kingdom
MH  - Urinary Incontinence, Stress/physiopathology/*surgery
MH  - *Urination
EDAT- 2012/08/25 06:00
MHDA- 2013/04/23 06:00
CRDT- 2012/08/25 06:00
PHST- 2011/11/24 00:00 [received]
PHST- 2012/05/25 00:00 [revised]
PHST- 2012/06/12 00:00 [accepted]
PHST- 2012/08/25 06:00 [entrez]
PHST- 2012/08/25 06:00 [pubmed]
PHST- 2013/04/23 06:00 [medline]
AID - S0301-2115(12)00289-8 [pii]
AID - 10.1016/j.ejogrb.2012.06.022 [doi]
PST - ppublish
SO  - Eur J Obstet Gynecol Reprod Biol. 2012 Nov;165(1):115-21. doi:
      10.1016/j.ejogrb.2012.06.022. Epub 2012 Aug 20.


PMID- 22917903
OWN - NLM
STAT- MEDLINE
DCOM- 20121106
LR  - 20190923
IS  - 0253-9772 (Print)
IS  - 0253-9772 (Linking)
VI  - 34
IP  - 8
DP  - 2012 Aug
TI  - [Cell fate switch: lineage reprogramming].
PG  - 985-92
AB  - It has been demonstrated that mature cells could switch their fate by the
      technologies for reprogramming, such as somatic cell nuclear transfer and induced
      pluripotent stem cells. Recently, this conclusion was further confirmed. It was
      found that mature differentiated cells could be directly converted into other
      somatic cells or progenitors with some defined transcription factors. This
      technology is called lineage reprogramming, which provides an attractive novel
      alternative to regenerative medicine and animal biotechnology. It is a more
      convenient and more effective system with less ethical issues. Moreover, lineage 
      reprogramming technology could also facilitate researches on regulation of gene
      expression. This review highlights the procedures of reprogramming, its
      characteristics, and significant promise in biomedical applications.
FAU - Sun, Hong-Yan
AU  - Sun HY
AD  - College of Animal Science and Technology, Nanjing Agricultural University,
      Nanjing, China. sunshy2772@163.com
FAU - Wang, Feng
AU  - Wang F
FAU - Cao, Wen-Guang
AU  - Cao WG
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - China
TA  - Yi Chuan
JT  - Yi chuan = Hereditas
JID - 9436478
SB  - IM
MH  - Animals
MH  - Biotechnology/*methods
MH  - Cell Lineage/*genetics
MH  - Cellular Reprogramming/*genetics
MH  - Humans
MH  - Regenerative Medicine/*methods
EDAT- 2012/08/25 06:00
MHDA- 2012/11/07 06:00
CRDT- 2012/08/25 06:00
PHST- 2012/08/25 06:00 [entrez]
PHST- 2012/08/25 06:00 [pubmed]
PHST- 2012/11/07 06:00 [medline]
AID - 0253-9772(2012)08-985-08 [pii]
AID - 10.3724/sp.j.1005.2012.00985 [doi]
PST - ppublish
SO  - Yi Chuan. 2012 Aug;34(8):985-92. doi: 10.3724/sp.j.1005.2012.00985.


PMID- 22917844
OWN - NLM
STAT- MEDLINE
DCOM- 20140616
LR  - 20211021
IS  - 1461-7005 (Electronic)
IS  - 1362-3613 (Linking)
VI  - 17
IP  - 6
DP  - 2013 Nov
TI  - Priorities for autism spectrum disorder risk communication and ethics.
PG  - 701-22
LID - 10.1177/1362361312453511 [doi]
AB  - Autism spectrum disorders are an issue of increasing public health significance. 
      The incidence of autism spectrum disorders has been increasing in recent years,
      and they are associated with significant personal and financial impacts for
      affected persons and their families. In recent years, a large number of
      scientific studies have been undertaken, which investigate genetic and
      environmental risk factors for autism, with more studies underway. At present,
      much remains unknown regarding autism spectrum disorder risk factors, but the
      emerging picture of causation is in many cases complex, with multiple genes and
      gene-environment interactions being at play. The complexity and uncertainty
      surrounding autism spectrum disorder risk factors raise a number of questions
      regarding the ethical considerations that should be taken into account when
      undertaking autism spectrum disorder risk communication. At present, however,
      little has been written regarding autism spectrum disorder risk communication and
      ethics. This article summarizes the findings of a recent conference investigating
      ethical considerations and policy recommendations in autism spectrum disorder
      risk communication, which to the authors' knowledge is the first of its kind.
      Here, the authors discuss a number of issues, including uncertainty;
      comprehension; inadvertent harm; justice; and the appropriate roles of
      clinicians, scientists, and the media in autism spectrum disorder risk
      communication.
FAU - Yudell, Michael
AU  - Yudell M
AD  - Drexel University, USA.
FAU - Tabor, Holly K
AU  - Tabor HK
FAU - Dawson, Geraldine
AU  - Dawson G
FAU - Rossi, John
AU  - Rossi J
FAU - Newschaffer, Craig
AU  - Newschaffer C
CN  - Working Group in Autism Risk Communication and Ethics
LA  - eng
GR  - R00 HG004316/HG/NHGRI NIH HHS/United States
GR  - R13 ES017394/ES/NIEHS NIH HHS/United States
GR  - 1R13ES017394-01/ES/NIEHS NIH HHS/United States
PT  - Congress
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120823
PL  - England
TA  - Autism
JT  - Autism : the international journal of research and practice
JID - 9713494
SB  - IM
MH  - *Child Development Disorders, Pervasive
MH  - *Communication
MH  - *Ethics, Medical
MH  - Health Policy
MH  - Humans
MH  - Information Dissemination/ethics
MH  - *Risk
PMC - PMC8487592
MID - NIHMS692952
OTO - NOTNLM
OT  - autism
OT  - ethics
OT  - risk communication
IR  - Bergey E
FIR - Bergey, Evon
IR  - Bono L
FIR - Bono, Laura
IR  - Croen L
FIR - Croen, Lisa
IR  - Permanente K
FIR - Permanente, Kaiser
IR  - Goldman LR
FIR - Goldman, Lynn R
IR  - Grinker RR
FIR - Grinker, Roy Richard
IR  - Peay H
FIR - Peay, Holly
IR  - Pinto-Martin J
FIR - Pinto-Martin, Jennifer
IR  - Rall G
FIR - Rall, Glenn
IR  - Fischhoff B
FIR - Fischhoff, Baruch
IR  - Hertz-Picciotto I
FIR - Hertz-Picciotto, Irva
IR  - Rowe M
FIR - Rowe, Michelle
IR  - Ruttenberg J
FIR - Ruttenberg, Jean
IR  - Salmon D
FIR - Salmon, Daniel
IR  - Szatmari P
FIR - Szatmari, Peter
IR  - Yeargin-Allsopp M
FIR - Yeargin-Allsopp, Marshalyn
EDAT- 2012/08/25 06:00
MHDA- 2014/06/17 06:00
CRDT- 2012/08/25 06:00
PHST- 2012/08/25 06:00 [entrez]
PHST- 2012/08/25 06:00 [pubmed]
PHST- 2014/06/17 06:00 [medline]
AID - 1362361312453511 [pii]
AID - 10.1177/1362361312453511 [doi]
PST - ppublish
SO  - Autism. 2013 Nov;17(6):701-22. doi: 10.1177/1362361312453511. Epub 2012 Aug 23.


PMID- 22917779
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20211021
IS  - 1872-8294 (Electronic)
IS  - 0169-409X (Linking)
VI  - 64
IP  - 13
DP  - 2012 Oct
TI  - Interactions of nanomaterials and biological systems: Implications to
      personalized nanomedicine.
PG  - 1363-84
LID - 10.1016/j.addr.2012.08.005 [doi]
LID - S0169-409X(12)00238-4 [pii]
AB  - The application of nanotechnology to personalized medicine provides an
      unprecedented opportunity to improve the treatment of many diseases.
      Nanomaterials offer several advantages as therapeutic and diagnostic tools due to
      design flexibility, small sizes, large surface-to-volume ratio, and ease of
      surface modification with multivalent ligands to increase avidity for target
      molecules. Nanomaterials can be engineered to interact with specific biological
      components, allowing them to benefit from the insights provided by personalized
      medicine techniques. To tailor these interactions, a comprehensive knowledge of
      how nanomaterials interact with biological systems is critical. Herein, we
      discuss how the interactions of nanomaterials with biological systems can guide
      their design for diagnostic, imaging and drug delivery purposes. A general
      overview of nanomaterials under investigation is provided with an emphasis on
      systems that have reached clinical trials. Finally, considerations for the
      development of personalized nanomedicines are summarized such as the potential
      toxicity, scientific and technical challenges in fabricating them, and regulatory
      and ethical issues raised by the utilization of nanomaterials.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Zhang, Xue-Qing
AU  - Zhang XQ
AD  - Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology,
      Brigham and Women's Hospital, Harvard Medical School, 75 Francis St., Boston, MA 
      02115, USA.
FAU - Xu, Xiaoyang
AU  - Xu X
FAU - Bertrand, Nicolas
AU  - Bertrand N
FAU - Pridgen, Eric
AU  - Pridgen E
FAU - Swami, Archana
AU  - Swami A
FAU - Farokhzad, Omid C
AU  - Farokhzad OC
LA  - eng
GR  - HHSN268201000045C/HL/NHLBI NIH HHS/United States
GR  - U54 CA151884/CA/NCI NIH HHS/United States
GR  - 1F32CA168163-01/CA/NCI NIH HHS/United States
GR  - CAPMC/ CIHR/Canada
GR  - F32 CA168163/CA/NCI NIH HHS/United States
GR  - CA151884/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120817
PL  - Netherlands
TA  - Adv Drug Deliv Rev
JT  - Advanced drug delivery reviews
JID - 8710523
RN  - 0 (Ligands)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Ligands
MH  - *Nanomedicine
MH  - Nanostructures/*therapeutic use
MH  - *Precision Medicine
MH  - Protein Binding
PMC - PMC3517211
MID - NIHMS401532
EDAT- 2012/08/25 06:00
MHDA- 2013/03/13 06:00
CRDT- 2012/08/25 06:00
PHST- 2012/06/01 00:00 [received]
PHST- 2012/07/25 00:00 [revised]
PHST- 2012/08/09 00:00 [accepted]
PHST- 2012/08/25 06:00 [entrez]
PHST- 2012/08/25 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
AID - S0169-409X(12)00238-4 [pii]
AID - 10.1016/j.addr.2012.08.005 [doi]
PST - ppublish
SO  - Adv Drug Deliv Rev. 2012 Oct;64(13):1363-84. doi: 10.1016/j.addr.2012.08.005.
      Epub 2012 Aug 17.


PMID- 22917227
OWN - NLM
STAT- MEDLINE
DCOM- 20130116
LR  - 20171116
IS  - 1878-0814 (Electronic)
IS  - 1877-1173 (Linking)
VI  - 111
DP  - 2012
TI  - Induction of somatic cell reprogramming using the microRNA miR-302.
PG  - 83-107
LID - 10.1016/B978-0-12-398459-3.00004-6 [doi]
AB  - Since the discovery of pluripotent stem cells, scientists have envisioned their
      use in regenerative medicine. Unfortunately, such application of embryonic
      pluripotent stem cells has been impeded by ethical concerns as well as other
      obstacles. In light of this, the scientific community has begun to explore
      somatic cell reprogramming (SCR) as a means of producing induced pluripotent stem
      cells (iPSCs) from somatic cells. Although still far from being clinically
      applicable, SCR has become a hot research topic, with many groups working to
      understand its underlying mechanism. The standard method for inducing SCR is
      achieved by forced expression of four transcription factors defined by Yamanaka
      and Yu et al. Regrettably, iPSCs produced by the four-factor method tend to be
      tumorigenic, making them unsafe for clinical application. Recently, a new method 
      has been identified to generate iPSCs through forced expression of an embryonic
      stem cell (ESC)-enriched microRNA, miR-302. This method holds a distinct
      advantage over the four-factor method because it can reprogram somatic cells to
      tumor-free iPSCs. Also, these miR-302-induced iPSCs, termed "mirPSCs,"
      demonstrate a clear mechanism, which explains the process of reprogramming as a
      response to global DNA demethylation-the first sign of SCR. Nevertheless,
      miR-302-induced reprogramming is dose-dependent, and microRNA (miRNA)
      concentration must be within a specific range for the reprogramming to occur. In 
      addition, excessive overexpression of miR-302 in mirPS cells must not occur;
      otherwise, they will undergo early senescence. mirPSCs represent a new source of 
      pluripotent stem cells without the tumorigenicity traditionally attributed to
      iPSCs. Looking forward, the next challenge lies with surmounting senescence, an
      obstacle that often limits stem cell expansion and prevents researchers from
      growing the large quantities of iPSCs needed for therapeutic use.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Kelley, Karen
AU  - Kelley K
AD  - Division of Regenerative Medicine, WJWU & LYNN Institute for Stem Cell Research, 
      Santa Fe Springs, California, USA.
FAU - Lin, Shi-Lung
AU  - Lin SL
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Prog Mol Biol Transl Sci
JT  - Progress in molecular biology and translational science
JID - 101498165
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Animals
MH  - Cell Transformation, Neoplastic/genetics/pathology
MH  - Cellular Reprogramming/*genetics
MH  - Cellular Senescence/genetics
MH  - Embryonic Development/genetics
MH  - Genes, Tumor Suppressor
MH  - Humans
MH  - MicroRNAs/genetics/*metabolism
EDAT- 2012/08/25 06:00
MHDA- 2013/01/17 06:00
CRDT- 2012/08/25 06:00
PHST- 2012/08/25 06:00 [entrez]
PHST- 2012/08/25 06:00 [pubmed]
PHST- 2013/01/17 06:00 [medline]
AID - B978-0-12-398459-3.00004-6 [pii]
AID - 10.1016/B978-0-12-398459-3.00004-6 [doi]
PST - ppublish
SO  - Prog Mol Biol Transl Sci. 2012;111:83-107. doi:
      10.1016/B978-0-12-398459-3.00004-6.


PMID- 22917224
OWN - NLM
STAT- MEDLINE
DCOM- 20130116
LR  - 20141120
IS  - 1878-0814 (Electronic)
IS  - 1877-1173 (Linking)
VI  - 111
DP  - 2012
TI  - Generation of induced pluripotent stem cells from somatic cells.
PG  - 1-26
LID - 10.1016/B978-0-12-398459-3.00001-0 [doi]
AB  - The technology for generation of induced pluripotent stem cell (iPSC) from
      somatic cells emerged to circumvent the ethical and immunological limitations of 
      embryonic stem cell (ESC). The recent progress of iPSC technology offers an
      unprecedented tool for regenerative medicine; however, integrating viral-driven
      iPSCs prohibits clinical applications by their genetic alterations and
      tumorigenicity. Various approaches including nonintegrating, nonviral, and
      nongenetic methods have been developed for generating clinically compatible
      iPSCs. In addition, approaches for using more clinically convenient or compatible
      source cells replacing fibroblasts have been actively pursued. While iPSC and ESC
      closely resemble in genomic, cell biologic, and phenotypic characteristics, these
      two pluripotent stem cells are not identical in terms of differentiation capacity
      and epigenetic features. In this chapter, we deal with the current techniques of 
      generating iPSCs and their various characteristics.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Sohn, Young-Doug
AU  - Sohn YD
AD  - Department of Medicine, Division of Cardiology, Emory University School of
      Medicine, Atlanta, Georgia, USA.
FAU - Han, Ji Woong
AU  - Han JW
FAU - Yoon, Young-sup
AU  - Yoon YS
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Prog Mol Biol Transl Sci
JT  - Progress in molecular biology and translational science
JID - 101498165
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Cellular Reprogramming/genetics
MH  - Epigenesis, Genetic
MH  - Gene Transfer Techniques
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*cytology
MH  - Models, Biological
MH  - Transcription Factors/metabolism
EDAT- 2012/08/25 06:00
MHDA- 2013/01/17 06:00
CRDT- 2012/08/25 06:00
PHST- 2012/08/25 06:00 [entrez]
PHST- 2012/08/25 06:00 [pubmed]
PHST- 2013/01/17 06:00 [medline]
AID - B978-0-12-398459-3.00001-0 [pii]
AID - 10.1016/B978-0-12-398459-3.00001-0 [doi]
PST - ppublish
SO  - Prog Mol Biol Transl Sci. 2012;111:1-26. doi: 10.1016/B978-0-12-398459-3.00001-0.


PMID- 22917211
OWN - NLM
STAT- MEDLINE
DCOM- 20130116
LR  - 20191210
IS  - 1527-5418 (Electronic)
IS  - 0890-8567 (Linking)
VI  - 51
IP  - 9
DP  - 2012 Sep
TI  - Practice parameter on gay, lesbian, or bisexual sexual orientation, gender
      nonconformity, and gender discordance in children and adolescents.
PG  - 957-74
LID - 10.1016/j.jaac.2012.07.004 [doi]
AB  - Children and adolescents who are growing up gay, lesbian, bisexual, gender
      nonconforming, or gender discordant experience unique developmental challenges.
      They are at risk for certain mental health problems, many of which are
      significantly correlated with stigma and prejudice. Mental health professionals
      have an important role to play in fostering healthy development in this
      population. Influences on sexual orientation, gender nonconformity, and gender
      discordance, and their developmental relationships to each other, are reviewed.
      Practice principles and related issues of cultural competence, research needs,
      and ethics are discussed.
CI  - Copyright (c) 2012 American Academy of Child and Adolescent Psychiatry. Published
      by Elsevier Inc. All rights reserved.
FAU - Adelson, Stewart L
AU  - Adelson SL
CN  - American Academy of Child and Adolescent Psychiatry (AACAP) Committee on Quality 
      Issues (CQI)
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Am Acad Child Adolesc Psychiatry
JT  - Journal of the American Academy of Child and Adolescent Psychiatry
JID - 8704565
SB  - IM
MH  - Adaptation, Psychological
MH  - Adolescent
MH  - Age Factors
MH  - Bisexuality/*psychology
MH  - Bullying/psychology
MH  - Child
MH  - Comorbidity
MH  - *Critical Pathways
MH  - Female
MH  - *Gender Identity
MH  - Homosexuality, Female/*psychology
MH  - Homosexuality, Male/*psychology
MH  - Humans
MH  - Male
MH  - Mental Disorders/*diagnosis/*psychology
MH  - Peer Group
MH  - Psychosexual Development
MH  - Rejection, Psychology
MH  - Risk Factors
MH  - Sexism/psychology
MH  - Social Stigma
IR  - Walter HJ
FIR - Walter, Heather J
IR  - Bukstein OG
FIR - Bukstein, Oscar G
IR  - Bellonci C
FIR - Bellonci, Christopher
IR  - Benson RS
FIR - Benson, R Scott
IR  - Chrisman A
FIR - Chrisman, Allan
IR  - Farchione TR
FIR - Farchione, Tiffany R
IR  - Hamilton J
FIR - Hamilton, John
IR  - Keable H
FIR - Keable, Helene
IR  - Kinlan J
FIR - Kinlan, Joan
IR  - Quiterio N
FIR - Quiterio, Nicole
IR  - Schoettle U
FIR - Schoettle, Ulrich
IR  - Siegel M
FIR - Siegel, Matthew
IR  - Stock S
FIR - Stock, Saundra
IR  - Medicus J
FIR - Medicus, Jennifer
EDAT- 2012/08/25 06:00
MHDA- 2013/01/17 06:00
CRDT- 2012/08/25 06:00
PHST- 2012/06/12 00:00 [received]
PHST- 2012/07/02 00:00 [accepted]
PHST- 2012/08/25 06:00 [entrez]
PHST- 2012/08/25 06:00 [pubmed]
PHST- 2013/01/17 06:00 [medline]
AID - S0890-8567(12)00500-X [pii]
AID - 10.1016/j.jaac.2012.07.004 [doi]
PST - ppublish
SO  - J Am Acad Child Adolesc Psychiatry. 2012 Sep;51(9):957-74. doi:
      10.1016/j.jaac.2012.07.004.


PMID- 22917085
OWN - NLM
STAT- MEDLINE
DCOM- 20130423
LR  - 20211021
IS  - 1475-925X (Electronic)
IS  - 1475-925X (Linking)
VI  - 11
DP  - 2012 Aug 23
TI  - Second pilot trials of the STAR-Liege protocol for tight glycemic control in
      critically ill patients.
PG  - 58
LID - 10.1186/1475-925X-11-58 [doi]
AB  - BACKGROUND: Critically ill patients often present increased insulin resistance
      and stress-induced hyperglycemia. Tight glycemic control aims to reduce blood
      glucose (BG) levels and variability while ensuring safety from hypoglycemia. This
      paper presents the results of the second Belgian clinical trial using the
      customizable STAR framework in a target-to-range control approach. The main
      objective is reducing measurement frequency while maintaining performance and
      safety of the glycemic control. METHODS: The STAR-Liege 2 (SL2) protocol targeted
      the 100-140 mg/dL glycemic band and offered 2-hourly and 3-hourly interventions. 
      Only insulin rates were adjusted, and nutrition inputs were left to the attending
      clinicians. This protocol restricted the forecasted risk of BG < 90 mg/dL to a 5%
      level using a stochastic model of insulin sensitivity to assess patient-specific 
      responses to insulin and its future likely variability to optimize insulin
      interventions. The clinical trial was performed at the Centre Hospitalier
      Universitaire de Liege and included 9 patients. Results are compared to 24-hour
      pre-trial and 24-hour post-trial, but also to the results of the first pilot
      trial performed in Liege, STAR-Liege 1 (SL1). This trial was approved by the
      Ethics Committee of the Medical Faculty of the University of Liege (Liege,
      Belgium). RESULTS: During the SL2 trial, 91 measurements were taken over 194
      hours. BG levels were tightly distributed: 54.9% of BG within 100-140 mg/dL,
      40.7% were >/= 140 mg/dL and 4.4% were < 100 mg/dL with no BG < 70 mg/dL.
      Comparing these results with 24-hour pre-trial and post-trial shows that SL2
      reduced high and low BG levels and reduced glycemic variability. Nurses selected 
      3-hourly measurement only 5 of 16 times and overrode 12% of 91 recommended
      interventions (35% increased insulin rates and 65% decreased insulin rates). SL1 
      and SL2 present similar BG levels distribution (p > 0.05) with significantly
      reduced measurement frequency for SL2 (p < 0.05). CONCLUSIONS: The SL2 protocol
      succeeded in reducing clinical workload while maintaining safety and
      effectiveness of the glycemic control. SL2 was also shown to be safer and tighter
      than hospital control. Overall results validate the efficacy of significantly
      customizing the STAR framework.
FAU - Penning, Sophie
AU  - Penning S
AD  - Cardiovascular Research Centre, Institut de Physique, Universite de Liege,
      Institut de Physics, Allee du 6 Aout, 17 (Bat B5), Liege, B4000 Liege, Liege,
      Belgium. sophie.penning@ulg.ac.be
FAU - Le Compte, Aaron J
AU  - Le Compte AJ
FAU - Massion, Paul
AU  - Massion P
FAU - Moorhead, Katherine T
AU  - Moorhead KT
FAU - Pretty, Christopher G
AU  - Pretty CG
FAU - Preiser, Jean-Charles
AU  - Preiser JC
FAU - Shaw, Geoffrey M
AU  - Shaw GM
FAU - Suhaimi, Fatanah
AU  - Suhaimi F
FAU - Desaive, Thomas
AU  - Desaive T
FAU - Chase, J Geoffrey
AU  - Chase JG
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120823
PL  - England
TA  - Biomed Eng Online
JT  - Biomedical engineering online
JID - 101147518
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Blood Glucose/*metabolism
MH  - Critical Care/*methods
MH  - Critical Illness/*therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - Quality Control
MH  - Safety
MH  - Workload
PMC - PMC3511234
EDAT- 2012/08/25 06:00
MHDA- 2013/04/24 06:00
CRDT- 2012/08/25 06:00
PHST- 2012/06/18 00:00 [received]
PHST- 2012/07/27 00:00 [accepted]
PHST- 2012/08/25 06:00 [entrez]
PHST- 2012/08/25 06:00 [pubmed]
PHST- 2013/04/24 06:00 [medline]
AID - 1475-925X-11-58 [pii]
AID - 10.1186/1475-925X-11-58 [doi]
PST - epublish
SO  - Biomed Eng Online. 2012 Aug 23;11:58. doi: 10.1186/1475-925X-11-58.


PMID- 22916412
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20120824
IS  - 0031-4617 (Print)
IS  - 0031-4617 (Linking)
VI  - 67
IP  - 2
DP  - 2012 Jun
TI  - Our ethical responsibility in the transition to practice for new RNs.
PG  - 4-6; quiz 6-7
FAU - Mariani, Bette
AU  - Mariani B
AD  - Villanova University, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pa Nurse
JT  - The Pennsylvania nurse
JID - 19540010R
MH  - American Nurses' Association
MH  - *Attitude of Health Personnel
MH  - Education, Nursing, Continuing
MH  - *Ethics, Institutional
MH  - *Ethics, Nursing
MH  - Humans
MH  - Nursing Staff, Hospital/*ethics
MH  - Social Responsibility
MH  - Students, Nursing
MH  - United States
EDAT- 2012/08/25 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/08/25 06:00
PHST- 2012/08/25 06:00 [entrez]
PHST- 2012/08/25 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
PST - ppublish
SO  - Pa Nurse. 2012 Jun;67(2):4-6; quiz 6-7.


PMID- 22916411
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20120824
IS  - 0031-4617 (Print)
IS  - 0031-4617 (Linking)
VI  - 67
IP  - 2
DP  - 2012 Jun
TI  - Ethics and nursing.
PG  - 3, 26
FAU - Alichnie, Christine
AU  - Alichnie C
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pa Nurse
JT  - The Pennsylvania nurse
JID - 19540010R
MH  - Delivery of Health Care/*ethics
MH  - Education, Nursing/*methods
MH  - *Ethics, Nursing
MH  - Humans
MH  - United States
EDAT- 2012/08/25 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/08/25 06:00
PHST- 2012/08/25 06:00 [entrez]
PHST- 2012/08/25 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
PST - ppublish
SO  - Pa Nurse. 2012 Jun;67(2):3, 26.


PMID- 22916399
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20120824
IS  - 0038-0814 (Print)
IS  - 0038-0814 (Linking)
IP  - 767
DP  - 2012 Jul-Aug
TI  - [Skin allograft, from the donor to the burn patient].
PG  - 46-8
AB  - Severely burned patients are treated through the use of donor skin or skin
      allografts. It is a vital treatment. From the donor to the recipient, the process
      involves numerous procedures which are performed in accordance with ethical and
      medical safety rules.
FAU - Gaucher, Sonia
AU  - Gaucher S
AD  - Service de chirurgie generale, plastique et ambulatoire, Hotel Dieu (AP-HP),
      Paris.
FAU - Marchix, Thierry
AU  - Marchix T
FAU - Jarraya, Mohamed
AU  - Jarraya M
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - La greffe de peau, du donneur au patient brule.
PL  - France
TA  - Soins
JT  - Soins; la revue de reference infirmiere
JID - 20910580R
MH  - Burns/*surgery
MH  - Disease Transmission, Infectious/prevention & control
MH  - Humans
MH  - *Skin Transplantation
MH  - Tissue Donors
MH  - Transplantation, Homologous
EDAT- 2012/08/25 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/08/25 06:00
PHST- 2012/08/25 06:00 [entrez]
PHST- 2012/08/25 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
PST - ppublish
SO  - Soins. 2012 Jul-Aug;(767):46-8.


PMID- 22915826
OWN - NLM
STAT- MEDLINE
DCOM- 20130227
LR  - 20220318
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 12
DP  - 2012 Dec
TI  - Post-trial access to study medication: a Brazilian e-survey with major
      stakeholders in clinical research.
PG  - 757-62
LID - 10.1136/medethics-2011-100127 [doi]
AB  - OBJECTIVES: To analyse the perspective of clinical research stakeholders
      concerning post-trial access to study medication. METHODS: Questionnaires and
      informed consents were sent through e-mail to 599 ethics committee (EC) members, 
      290 clinical investigators (HIV/AIDS and Diabetes) and 53 sponsors in Brazil.
      Investigators were also asked to submit the questionnaire to their research
      patients. Two reminders were sent to participants. RESULTS: The response rate was
      21%, 20% and 45% in EC, investigators and sponsors' groups, respectively. 54
      patients answered the questionnaire through their doctors. The least informative 
      item in the consent form was how to obtain the study medication after trial. If a
      benefit were demonstrated in the study, 60% of research participants and 35% of
      EC answered that all patients should continue receiving study medication after
      trial; 43% of investigators believed the medication should be given to
      participants, and 40% to subjects who participated and benefited from treatment. 
      For 50% of the sponsors, study medication should be assured to participants who
      had benefited from treatment. The majority of responders answered that medication
      should be provided free by sponsors; investigators and sponsors believed the
      medication should be kept until available in the public health sector; EC members
      said that the patient should keep the benefit; patients answered that benefits
      should be assured for life. CONCLUSIONS: Due to the study limitations, the
      results cannot be generalised; however, the data can contribute to discussion of 
      this complex topic through analysing the views of stakeholders in clinical
      research in Brazil.
FAU - Dainesi, Sonia M
AU  - Dainesi SM
AD  - Medicina Preventiva, University of Sao Paulo, Av Dr Arnaldo 455, 2 degrees andar,
      Sao Paulo, SP 05403-000, Brazil. sdainesi@gmail.com
FAU - Goldbaum, Moises
AU  - Goldbaum M
LA  - eng
PT  - Journal Article
DEP - 20120821
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Brazil
MH  - *Clinical Trials as Topic/economics/ethics
MH  - *Drug Industry/economics/ethics
MH  - Ethics Committees, Research
MH  - Health Services Accessibility/*ethics
MH  - Humans
MH  - Research Design
MH  - *Research Personnel/ethics/statistics & numerical data
MH  - *Research Subjects
MH  - *Research Support as Topic
MH  - Surveys and Questionnaires
EDAT- 2012/08/24 06:00
MHDA- 2013/02/28 06:00
CRDT- 2012/08/24 06:00
PHST- 2012/08/24 06:00 [entrez]
PHST- 2012/08/24 06:00 [pubmed]
PHST- 2013/02/28 06:00 [medline]
AID - medethics-2011-100127 [pii]
AID - 10.1136/medethics-2011-100127 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Dec;38(12):757-62. doi: 10.1136/medethics-2011-100127. Epub
      2012 Aug 21.


PMID- 22915703
OWN - NLM
STAT- MEDLINE
DCOM- 20121210
LR  - 20131121
IS  - 0301-2603 (Print)
IS  - 0301-2603 (Linking)
VI  - 40
IP  - 9
DP  - 2012 Sep
TI  - [Required knowledge for neuroendovascular surgeon. (1)Practical basic knowledge
      of radiation, drug, and ethics for neurointerventionalists].
PG  - 813-21
FAU - Sorimachi, Takatoshi
AU  - Sorimachi T
AD  - Department of Neurosurgery, University of Niigata, Japan.
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - No Shinkei Geka
JT  - No shinkei geka. Neurological surgery
JID - 0377015
RN  - 0 (Anticoagulants)
RN  - 0 (Contrast Media)
RN  - 0 (Platelet Aggregation Inhibitors)
RN  - 9679TC07X4 (Iodine)
SB  - IM
MH  - *Angiography, Digital Subtraction
MH  - Anticoagulants/adverse effects
MH  - Contrast Media/adverse effects
MH  - *Endovascular Procedures
MH  - *Ethics, Medical
MH  - Humans
MH  - Iodine/adverse effects
MH  - Kidney Diseases
MH  - *Neurosurgery
MH  - Occupational Injuries/prevention & control
MH  - Platelet Aggregation Inhibitors/adverse effects
MH  - Radiation Dosage
MH  - Radiation Injuries/etiology
EDAT- 2012/08/24 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/08/24 06:00
PHST- 2012/08/24 06:00 [entrez]
PHST- 2012/08/24 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - 1436101821 [pii]
PST - ppublish
SO  - No Shinkei Geka. 2012 Sep;40(9):813-21.


PMID- 22915004
OWN - NLM
STAT- MEDLINE
DCOM- 20130124
LR  - 20211021
IS  - 1435-1269 (Electronic)
IS  - 0948-6704 (Linking)
VI  - 45
IP  - 6
DP  - 2012 Aug
TI  - [Ethics in geriatrics].
PG  - 545-55; quiz 556-7
LID - 10.1007/s00391-012-0344-0 [doi]
AB  - Ethics is a fundamental part of geriatric medicine. Ethical questions are
      important in all fields of medicine but in geriatrics they are of particular
      importance. This branch of medicine is concerned with the care and health
      problems of mostly very old people close to the end of life. They are physically,
      mentally and socially vulnerable, frail individuals with a high risk for
      progressive deficits in physical and cognitive functions and are thus
      progressively dependent on help and care. Decisions about medical interventions
      are easier when the patients concerned have an intact decisional capacity and is 
      more complex and difficult when dealing with multimorbid, frequently cognitively 
      impaired very old individuals. Ethics is about systematically asking the right
      questions. This process should be logically structured but questions may remain
      unanswered. It is about questioning prejudices and modes of action, it means
      explaining terminology, requesting the best facts possible, formulating
      definitions and helping to logically reflect on a problem. Good ethics begins
      with good facts, not with groundless assumptions.
FAU - Fruhwald, T
AU  - Fruhwald T
AD  - Abteilung fur Akutgeriatrie, Krankenhaus Hietzing mit Neurologischem Zentrum
      Rosenhugel, Wolkersbergenstr. 1, 1130, Wien, Osterreich.
      thomas.fruehwald@wienkav.at
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Ethik in der Geriatrie.
PL  - Germany
TA  - Z Gerontol Geriatr
JT  - Zeitschrift fur Gerontologie und Geriatrie
JID - 9506215
SB  - IM
MH  - Delivery of Health Care/*ethics
MH  - Geriatrics/*ethics
MH  - Germany
MH  - Health Services for the Aged/*ethics
EDAT- 2012/08/24 06:00
MHDA- 2013/01/25 06:00
CRDT- 2012/08/24 06:00
PHST- 2012/08/24 06:00 [entrez]
PHST- 2012/08/24 06:00 [pubmed]
PHST- 2013/01/25 06:00 [medline]
AID - 10.1007/s00391-012-0344-0 [doi]
PST - ppublish
SO  - Z Gerontol Geriatr. 2012 Aug;45(6):545-55; quiz 556-7. doi:
      10.1007/s00391-012-0344-0.


PMID- 22914849
OWN - NLM
STAT- MEDLINE
DCOM- 20131023
LR  - 20130418
IS  - 1477-0970 (Electronic)
IS  - 1352-4585 (Linking)
VI  - 19
IP  - 4
DP  - 2013 Apr
TI  - Time to first relapse as an endpoint in multiple sclerosis clinical trials.
PG  - 466-74
LID - 10.1177/1352458512457841 [doi]
AB  - BACKGROUND: The increasing number of effective therapies to treat multiple
      sclerosis (MS) raises ethical concerns for the use of placebo in clinical trials,
      suggesting that new clinical trial design strategies are needed. OBJECTIVES: To
      evaluate time to first relapse as an endpoint for MS clinical trials. METHODS: A 
      recently-developed model fitting the distribution of time to first relapse in MS 
      was used for simulations estimating the sample sizes of trials using this as an
      outcome, and for comparison with the size of trials using the annualized relapse 
      rate (ARR) as the primary outcome. RESULTS: Trials based on time to first relapse
      were feasible, requiring sample sizes that were similar or even smaller than if
      the study was based on ARR instead. In the case of low ARR (0.4 relapses/year),
      as is expected in future trials, the 1-year trials designed to detect a treatment
      effect of 30%, with 90% power, require fewer patients when based on time to first
      relapse (470 patients/arm) than if based on ARR (540 patients/arm). CONCLUSIONS: 
      Our simulations show that time to first relapse is not less powerful than ARR in 
      MS trials; thus, this measure would be a potentially useful primary outcome
      offering the advantage of an ethically sound design, as the patients randomized
      to placebo can then switch to the active drug, once they relapse. A potential
      drawback is the loss of information for other endpoints collected at fixed time
      points.
FAU - Sormani, M P
AU  - Sormani MP
AD  - Department of Health Sciences (DISSAL), University of Genova, Via Pastore 1,
      Genova, 16132, Italy. mariapia.sormani@unige.it
FAU - Signori, A
AU  - Signori A
FAU - Siri, P
AU  - Siri P
FAU - De Stefano, N
AU  - De Stefano N
LA  - eng
PT  - Journal Article
DEP - 20120822
PL  - England
TA  - Mult Scler
JT  - Multiple sclerosis (Houndmills, Basingstoke, England)
JID - 9509185
SB  - IM
MH  - Humans
MH  - *Models, Theoretical
MH  - Multiple Sclerosis, Relapsing-Remitting/*drug therapy
MH  - *Research Design
EDAT- 2012/08/24 06:00
MHDA- 2013/10/24 06:00
CRDT- 2012/08/24 06:00
PHST- 2012/08/24 06:00 [entrez]
PHST- 2012/08/24 06:00 [pubmed]
PHST- 2013/10/24 06:00 [medline]
AID - 1352458512457841 [pii]
AID - 10.1177/1352458512457841 [doi]
PST - ppublish
SO  - Mult Scler. 2013 Apr;19(4):466-74. doi: 10.1177/1352458512457841. Epub 2012 Aug
      22.


PMID- 22914476
OWN - NLM
STAT- MEDLINE
DCOM- 20121029
LR  - 20140527
IS  - 1873-233X (Electronic)
IS  - 0029-7844 (Linking)
VI  - 120
IP  - 3
DP  - 2012 Sep
TI  - When legislators play doctor: the ethics of mandatory preabortion ultrasound
      examinations.
PG  - 647-9
LID - 10.1097/AOG.0b013e318265e101 [doi]
AB  - Many states have proposed or enacted laws that mandate that women undergo
      ultrasonography before electing pregnancy termination. In some cases, the
      legislation prescribes the form of ultrasound examination, requires that a woman 
      review the images produced, or both. Although ultrasonography may be a part of
      good and standard care before many abortion procedures, we argue that legislating
      imaging procedures inappropriately limits women's autonomy and undermines the
      physician-patient relationship as well as the physician's professional
      obligations to the patient. The timing, context, and way in which
      ultrasonography, or any medical test, is used and viewed should be decisions made
      between patient and provider, not decisions scripted by law.
FAU - Minkoff, Howard
AU  - Minkoff H
AD  - Department of Obstetrics and Gynecology, Maimonides Medical Center, SUNY
      Downstate, New York, New York 11219, USA. hminkoff@maimonidesmed.org
FAU - Ecker, Jeffrey
AU  - Ecker J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Obstet Gynecol
JT  - Obstetrics and gynecology
JID - 0401101
SB  - IM
CIN - Virtual Mentor. 2014 Apr;16(4):265-9. PMID: 24735574
MH  - Abortion, Legal/ethics/*legislation & jurisprudence
MH  - Female
MH  - Government Regulation
MH  - Humans
MH  - Informed Consent/ethics/legislation & jurisprudence
MH  - Mandatory Programs/*ethics/legislation & jurisprudence
MH  - Personal Autonomy
MH  - Physician-Patient Relations/ethics
MH  - Pregnancy
MH  - State Government
MH  - Ultrasonography, Prenatal/*ethics
MH  - United States
EDAT- 2012/08/24 06:00
MHDA- 2012/10/30 06:00
CRDT- 2012/08/24 06:00
PHST- 2012/08/24 06:00 [entrez]
PHST- 2012/08/24 06:00 [pubmed]
PHST- 2012/10/30 06:00 [medline]
AID - 10.1097/AOG.0b013e318265e101 [doi]
AID - 00006250-201209000-00022 [pii]
PST - ppublish
SO  - Obstet Gynecol. 2012 Sep;120(3):647-9. doi: 10.1097/AOG.0b013e318265e101.


PMID- 22914426
OWN - NLM
STAT- MEDLINE
DCOM- 20130510
LR  - 20121116
IS  - 1531-7072 (Electronic)
IS  - 1070-5295 (Linking)
VI  - 18
IP  - 6
DP  - 2012 Dec
TI  - Prioritizing registered donors in organ allocation: an ethical appraisal of the
      Israeli organ transplant law.
PG  - 707-11
LID - 10.1097/MCC.0b013e328357a2e2 [doi]
AB  - PURPOSE OF REVIEW: A new organ transplant law in Israel, which gives priority in 
      organ allocation to candidates who in various ways support organ donation, has
      resulted in a significant increase in organ donation in 2011. We provide an
      ethical analysis of the new law. RECENT FINDINGS: We note that by continuing to
      require opt-in consent, the Israeli law has an ethical advantage over opt-out
      laws, which may result in some use of organs from donors who have not consented. 
      We discuss the fair response to 'free-riding' candidates who, usually for
      religious reasons, are opposed to donation, but nevertheless seek a transplant,
      who will not receive any priority over candidates who have been registered donors
      for at least 3 years before listing. We spell out several reasons why it is
      potentially unfair to prioritize patients whose first-degree relatives are
      registered donors, whereas it is fair to prioritize candidates who have been
      living directed or nondirected donors. Finally, we note the difficulty of
      ensuring public awareness of the priority system, which is necessary for its
      fairness. SUMMARY: Athough needing some modifications, the new Israeli law is
      based on sound ethical approach that seems to begin already to bear fruits.
FAU - Lavee, Jacob
AU  - Lavee J
AD  - Heart Transplantation Unit, Department of Cardiac Surgery, Leviev Heart Center,
      Sheba Medical Center, Ramat Gan, Israel. jaylavee@netvision.net.il
FAU - Brock, Dan W
AU  - Brock DW
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Crit Care
JT  - Current opinion in critical care
JID - 9504454
SB  - IM
MH  - Health Care Rationing/legislation & jurisprudence
MH  - Humans
MH  - Israel
MH  - Living Donors/supply & distribution
MH  - Tissue and Organ Procurement/*ethics/*legislation & jurisprudence
EDAT- 2012/08/24 06:00
MHDA- 2013/05/11 06:00
CRDT- 2012/08/24 06:00
PHST- 2012/08/24 06:00 [entrez]
PHST- 2012/08/24 06:00 [pubmed]
PHST- 2013/05/11 06:00 [medline]
AID - 10.1097/MCC.0b013e328357a2e2 [doi]
PST - ppublish
SO  - Curr Opin Crit Care. 2012 Dec;18(6):707-11. doi: 10.1097/MCC.0b013e328357a2e2.


PMID- 22913838
OWN - NLM
STAT- MEDLINE
DCOM- 20130211
LR  - 20120823
IS  - 1532-849X (Electronic)
IS  - 1059-941X (Linking)
VI  - 21
IP  - 6
DP  - 2012 Aug
TI  - Ethical dilemmas in publishing. A rising tide of plagiarism?
PG  - 431-2
LID - 10.1111/j.1532-849X.2012.00904.x [doi]
FAU - Gerding, Alethea B
AU  - Gerding AB
LA  - eng
PT  - Editorial
PL  - United States
TA  - J Prosthodont
JT  - Journal of prosthodontics : official journal of the American College of
      Prosthodontists
JID - 9301275
MH  - Humans
MH  - *Plagiarism
MH  - Publications/*ethics
EDAT- 2012/08/24 06:00
MHDA- 2013/02/12 06:00
CRDT- 2012/08/24 06:00
PHST- 2012/08/24 06:00 [entrez]
PHST- 2012/08/24 06:00 [pubmed]
PHST- 2013/02/12 06:00 [medline]
AID - 10.1111/j.1532-849X.2012.00904.x [doi]
PST - ppublish
SO  - J Prosthodont. 2012 Aug;21(6):431-2. doi: 10.1111/j.1532-849X.2012.00904.x.


PMID- 22913778
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2045-4015 (Electronic)
IS  - 2045-4015 (Linking)
VI  - 1
IP  - 1
DP  - 2012 Apr 18
TI  - Giving oocytes to women in need: permitted, forbidden, or pressured? A
      commentary.
PG  - 16
LID - 10.1186/2045-4015-1-16 [doi]
AB  - There can be no starker contrast in egg donation than between Austria, where it
      is forbidden, and Israel, where it is encouraged to the extent that some Israeli 
      women go abroad in order to obtain these precious reproductive cells. There are
      grave ethical issues in some of the transactions involved, which may fall out
      with the definition of a gift. The ESHRE taskforce on cross-border reproductive
      care is keen to promote standards in this field, including the ethical standard
      of avoiding coercion.This is a commentary on http://www.ijhpr.org/content/1/1/15/
FAU - Shenfield, Francoise
AU  - Shenfield F
AD  - Reproductive Medicine Unit, University College London Hospitals, Euston Road,
      London NW1 3BU, UK. mfi@easynet.co.uk.
LA  - eng
PT  - Editorial
DEP - 20120418
PL  - England
TA  - Isr J Health Policy Res
JT  - Israel journal of health policy research
JID - 101584158
PMC - PMC3424833
EDAT- 2012/08/24 06:00
MHDA- 2012/08/24 06:01
CRDT- 2012/08/24 06:00
PHST- 2011/12/14 00:00 [received]
PHST- 2012/04/18 00:00 [accepted]
PHST- 2012/08/24 06:00 [entrez]
PHST- 2012/08/24 06:00 [pubmed]
PHST- 2012/08/24 06:01 [medline]
AID - 2045-4015-1-16 [pii]
AID - 10.1186/2045-4015-1-16 [doi]
PST - epublish
SO  - Isr J Health Policy Res. 2012 Apr 18;1(1):16. doi: 10.1186/2045-4015-1-16.


PMID- 22913734
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2045-4015 (Electronic)
IS  - 2045-4015 (Linking)
VI  - 1
IP  - 1
DP  - 2012 Apr 18
TI  - Patterns of globalized reproduction: Egg cells regulation in Israel and Austria.
PG  - 15
LID - 10.1186/2045-4015-1-15 [doi]
AB  - Since the successful introduction of in vitro fertilization in 1978, medically
      assisted reproduction (MAR) has proliferated in multiple clinical innovations.
      Consequently, egg cells have become an object of demand for both infertility
      treatment and stem cell research, and this raises complex legal, ethical, social 
      and economic issues.In this paper we compare how the procurement and use of human
      egg cells is regulated in two countries: Israel and Austria. Israel is known for 
      its scientific leadership, generous public funding, high utilization and liberal 
      regulation of assisted reproductive technology (ART). Austria lies at the other
      extreme of the regulatory spectrum in terms of restrictions on reproductive
      interventions.In both countries, however, there is a constant increase in the use
      of the technology, and recent legal developments make egg cells more accessible. 
      Also, in both countries the scarcity of egg cells in concert with the rising
      demand for donations has led to the emergence of cross-border markets and global 
      'reproductive tourism' practices. In Israel, in particular, a scandal known as
      the 'eggs affair' was followed by regulation that allowed egg cell donations from
      outside the country under certain conditions.Cross-border markets are developed
      by medical entrepreneurs, driven by global economic gaps, made possible by
      trans-national regulatory lacunae and find expression as consumer demand. The
      transnational practice of egg cell donations indicates the emergence of a global 
      public health issue, but there is a general lack of medical and epidemiological
      data on its efficacy and safety. We conclude that there is need for harmonisation
      of domestic laws and formulation of new instruments for international governance.
FAU - Shalev, Carmel
AU  - Shalev C
AD  - Department for Reproduction and Society, International Center for Health, Law and
      Ethics, Haifa University, Israel. cshalev@012.net.il.
FAU - Werner-Felmayer, Gabriele
AU  - Werner-Felmayer G
LA  - eng
PT  - Journal Article
DEP - 20120418
PL  - England
TA  - Isr J Health Policy Res
JT  - Israel journal of health policy research
JID - 101584158
PMC - PMC3424961
EDAT- 2012/08/24 06:00
MHDA- 2012/08/24 06:01
CRDT- 2012/08/24 06:00
PHST- 2011/03/02 00:00 [received]
PHST- 2012/04/18 00:00 [accepted]
PHST- 2012/08/24 06:00 [entrez]
PHST- 2012/08/24 06:00 [pubmed]
PHST- 2012/08/24 06:01 [medline]
AID - 2045-4015-1-15 [pii]
AID - 10.1186/2045-4015-1-15 [doi]
PST - epublish
SO  - Isr J Health Policy Res. 2012 Apr 18;1(1):15. doi: 10.1186/2045-4015-1-15.


PMID- 22913661
OWN - NLM
STAT- MEDLINE
DCOM- 20120914
LR  - 20191210
IS  - 1533-4406 (Electronic)
IS  - 0028-4793 (Linking)
VI  - 367
IP  - 10
DP  - 2012 Sep 6
TI  - Ethical considerations in studying drug safety--the Institute of Medicine report.
PG  - 959-64
LID - 10.1056/NEJMhle1207160 [doi]
FAU - Mello, Michelle M
AU  - Mello MM
AD  - Department of Health Policy and Management, Harvard School of Public Health,
      Boston, USA.
FAU - Goodman, Steven N
AU  - Goodman SN
FAU - Faden, Ruth R
AU  - Faden RR
LA  - eng
PT  - Journal Article
DEP - 20120822
PL  - United States
TA  - N Engl J Med
JT  - The New England journal of medicine
JID - 0255562
SB  - IM
MH  - *Bioethical Issues
MH  - Drug Approval
MH  - *Drug-Related Side Effects and Adverse Reactions
MH  - Humans
MH  - *Informed Consent
MH  - National Academies of Science, Engineering, and Medicine, U.S., Health and
      Medicine Division
MH  - *Product Surveillance, Postmarketing/standards
MH  - United States
MH  - United States Food and Drug Administration/*ethics
EDAT- 2012/08/24 06:00
MHDA- 2012/09/15 06:00
CRDT- 2012/08/24 06:00
PHST- 2012/08/24 06:00 [entrez]
PHST- 2012/08/24 06:00 [pubmed]
PHST- 2012/09/15 06:00 [medline]
AID - 10.1056/NEJMhle1207160 [doi]
PST - ppublish
SO  - N Engl J Med. 2012 Sep 6;367(10):959-64. doi: 10.1056/NEJMhle1207160. Epub 2012
      Aug 22.


PMID- 22913616
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121026
LR  - 20211021
IS  - 1748-7161 (Electronic)
IS  - 1748-7161 (Linking)
VI  - 7
IP  - 1
DP  - 2012 Aug 22
TI  - CT and radiographic analysis of sagittal profile changes following thoracoscopic 
      anterior scoliosis surgery.
PG  - 15
LID - 10.1186/1748-7161-7-15 [doi]
AB  - BACKGROUND: Previous studies report an increase in thoracic kyphosis after
      anterior approaches and a flattening of sagittal contours following posterior
      approaches. Difficulties with measuring sagittal parameters on radiographs are
      avoided with reformatted sagittal CT reconstructions due to the superior endplate
      clarity afforded by this imaging modality. METHODS: A prospective study of 30
      Lenke 1 adolescent idiopathic scoliosis (AIS) patients receiving selective
      thoracoscopic anterior spinal fusion (TASF) was performed. Participants had
      ethically approved low dose CT scans at minimum 24 months after surgery in
      addition to their standard care following surgery. The change in sagittal
      contours on supine CT was compared to standing radiographic measurements of the
      same patients and with previous studies. Inter-observer variability was assessed 
      as well as whether hypokyphotic and normokyphotic patient groups responded
      differently to the thoracoscopic anterior approach. RESULTS: Mean T5-12 kyphosis 
      Cobb angle increased by 11.8 degrees and lumbar lordosis increased by 5.9 degrees
      on standing radiographs two years after surgery. By comparison, CT measurements
      of kyphosis and lordosis increased by 12.3 degrees and 7.0 degrees respectively. 
      95% confidence intervals for inter-observer variability of sagittal contour
      measurements on supine CT ranged between 5-8 degrees. TASF had a slightly greater
      corrective effect on patients who were hypokyphotic before surgery compared with 
      those who were normokyphotic. CONCLUSIONS: Restoration of sagittal profile is an 
      important goal of scoliosis surgery, but reliable measurement with radiographs
      suffers from poor endplate clarity. TASF significantly improves thoracic kyphosis
      and lumbar lordosis while preserving proximal and distal junctional alignment in 
      thoracic AIS patients. Supine CT allows greater endplate clarity for sagittal
      Cobb measurements and linear relationships were found between supine CT and
      standing radiographic measurements. In this study, improvements in sagittal
      kyphosis and lordosis following surgery were in agreement with prior anterior
      surgery studies, and add to the current evidence suggesting that anterior
      correction is more capable than posterior approaches of addressing the sagittal
      component of both the instrumented and adjacent non instrumented segments
      following surgical correction of progressive Lenke 1 idiopathic scoliosis.
FAU - Izatt, Maree T
AU  - Izatt MT
AD  - Paediatric Spine Research Group, Queensland University of Technology and Mater
      Health Services Brisbane Ltd, Queensland, Australia. m.izatt@qut.edu.au.
FAU - Adam, Clayton J
AU  - Adam CJ
FAU - Verzin, Eugene J
AU  - Verzin EJ
FAU - Labrom, Robert D
AU  - Labrom RD
FAU - Askin, Geoffrey N
AU  - Askin GN
LA  - eng
PT  - Journal Article
DEP - 20120822
PL  - England
TA  - Scoliosis
JT  - Scoliosis
JID - 101271527
PMC - PMC3495407
EDAT- 2012/08/24 06:00
MHDA- 2012/08/24 06:01
CRDT- 2012/08/24 06:00
PHST- 2012/04/20 00:00 [received]
PHST- 2012/08/10 00:00 [accepted]
PHST- 2012/08/24 06:00 [entrez]
PHST- 2012/08/24 06:00 [pubmed]
PHST- 2012/08/24 06:01 [medline]
AID - 1748-7161-7-15 [pii]
AID - 10.1186/1748-7161-7-15 [doi]
PST - epublish
SO  - Scoliosis. 2012 Aug 22;7(1):15. doi: 10.1186/1748-7161-7-15.


PMID- 22913456
OWN - NLM
STAT- MEDLINE
DCOM- 20131216
LR  - 20130510
IS  - 1365-2885 (Electronic)
IS  - 0140-7783 (Linking)
VI  - 36
IP  - 3
DP  - 2013 Jun
TI  - The isolated perfused equine distal limb as an ex vivo model for pharmacokinetic 
      studies.
PG  - 292-7
LID - 10.1111/jvp.12001 [doi]
AB  - Even though intra-articular injections play an important role in the treatment of
      joint-related lameness in horses, little is known about pharmacokinetic
      properties of substances used. Therefore, an ex vivo model for pharmacokinetic
      studies was developed using distal forelimbs of slaughtered horses. The extremity
      was perfused with gassed Tyrode solution for up to 8 h. Tissue viability was
      confirmed by measurements of glucose consumption, lactate production, and lactate
      dehydrogenase activity in the perfusate. Standard criteria for tissue viability
      had been determined in preliminary experiments (n = 11), which also included
      histological examinations of the joint capsule. As the model's first
      implementation, the articular efflux rate of betamethasone (BM), administered as 
      BM disodium phosphate intra-articularly to the fetlock joint (4 mg BM/joint), was
      investigated. The concentration of BM in the venous perfusate of the radial vein 
      was measured by means of high-performance liquid chromatography. The average BM
      efflux rate per minute was calculated to be 5.1 mug/min with values ranging from 
      9 mug/min to 2.9 mug/min. 7.5 h after i.a. application, 2.3 mg BM had left the
      joint via the radial vein. Using this inexpensive setup, the presented model
      allows studying a variety of pharmacological topics without the ethical
      limitations of animal studies.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Friebe, M
AU  - Friebe M
AD  - Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary
      Medicine Hannover, Foundation, Hannover, Germany. maren.friebe@tiho-hannover.de
FAU - Stahl, J
AU  - Stahl J
FAU - Kietzmann, M
AU  - Kietzmann M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120823
PL  - England
TA  - J Vet Pharmacol Ther
JT  - Journal of veterinary pharmacology and therapeutics
JID - 7910920
RN  - 0 (Anti-Inflammatory Agents)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 9842X06Q6M (Betamethasone)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Administration, Intravenous/veterinary
MH  - Animals
MH  - Anti-Inflammatory Agents/administration & dosage/*pharmacokinetics
MH  - Betamethasone/administration & dosage/*pharmacokinetics
MH  - Cadaver
MH  - Female
MH  - Forelimb/*blood supply/physiology
MH  - Glucose/metabolism
MH  - Horses/*physiology
MH  - Lactic Acid/metabolism
MH  - Male
EDAT- 2012/08/24 06:00
MHDA- 2013/12/18 06:00
CRDT- 2012/08/24 06:00
PHST- 2012/02/07 00:00 [received]
PHST- 2012/07/23 00:00 [accepted]
PHST- 2012/08/24 06:00 [entrez]
PHST- 2012/08/24 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
AID - 10.1111/jvp.12001 [doi]
PST - ppublish
SO  - J Vet Pharmacol Ther. 2013 Jun;36(3):292-7. doi: 10.1111/jvp.12001. Epub 2012 Aug
      23.


PMID- 22913211
OWN - NLM
STAT- MEDLINE
DCOM- 20120906
LR  - 20120823
IS  - 1128-3602 (Print)
IS  - 1128-3602 (Linking)
VI  - 16
IP  - 6
DP  - 2012 Jun
TI  - Knowledge and skills needs for health professions about pharmacogenomics testing 
      field.
PG  - 781-8
AB  - BACKGROUND: Promise in the future, a disease could be ranked into genetic
      categories, allowing bespoke tailoring of medicine to maximize therapeutic
      effects and to reduce the potential for adverse drug response. This new feature
      requires for health professionals to have competencies not only for the basic
      skills of their discipline, but also for the understanding on why, when, and how 
      that knowledge should be applied to improve personalized therapies for their
      patients. Current opinion on basic competences of health professions includes
      knowledge and skills on two fundamental features: (1) genetics of disease, to
      allow the understanding and the identification of diseases associated to genetic 
      variations, and to facilitate the development of new genomic tests; and (2)
      ethical, social and economical implications that are fundamental to identify
      those factors that might contribute to a successful integration of
      pharmacogenomics into international health and public policy. AIM: Briefly, we
      described (1) current knowledge on genetic variations that interact with
      therapies and the need to detect them; (2) the most common available methods for 
      detecting mutations; and (3) ethical, social and economic issues related to
      pharmacogenetic testing and recording of genetic information (e.g., critical
      evaluation of the development of new tests, privacy, the current absence of
      public reimbursement, etc). CONCLUSIONS: These could be useful recommendations
      for academic institutions and educational programs to prepare health
      professionals with the necessary abilities for their future practice.
FAU - Di Francia, R
AU  - Di Francia R
AD  - Hematology-Oncology and Stem Cell Transplantation Unit, National Cancer
      Institute, Fondazione G. Pascale IRCCS, Naples, Italy. rdifrancia@iapharmagen.org
FAU - Valente, D
AU  - Valente D
FAU - Catapano, O
AU  - Catapano O
FAU - Rupolo, M
AU  - Rupolo M
FAU - Tirelli, U
AU  - Tirelli U
FAU - Berretta, M
AU  - Berretta M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - Eur Rev Med Pharmacol Sci
JT  - European review for medical and pharmacological sciences
JID - 9717360
SB  - IM
MH  - *Clinical Competence
MH  - Drug Industry
MH  - *Genetic Testing
MH  - Genetic Variation
MH  - Genotyping Techniques
MH  - *Health Occupations
MH  - Humans
MH  - *Knowledge
MH  - *Pharmacogenetics
EDAT- 2012/08/24 06:00
MHDA- 2012/09/07 06:00
CRDT- 2012/08/24 06:00
PHST- 2012/08/24 06:00 [entrez]
PHST- 2012/08/24 06:00 [pubmed]
PHST- 2012/09/07 06:00 [medline]
PST - ppublish
SO  - Eur Rev Med Pharmacol Sci. 2012 Jun;16(6):781-8.


PMID- 22912932
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2075-0528 (Electronic)
IS  - 2075-051X (Linking)
VI  - 12
IP  - 3
DP  - 2012 Aug
TI  - Successful resuscitation of an extremely low birth weight premature infant in
      delma island community hospital, United arab emirates.
PG  - 364-8
AB  - Because of their physical size and physiological immaturity, resuscitation of
      extremely very low birth weight premature infants is a big dilemma for
      neonatologists in any hospital. The resuscitation may present an additional
      challenge to the caregiver if it is undertaken in a remote community hospital
      with limited technical facilities and health personnel. We present the case of
      successful resuscitation of a 23-week-old premature infant, with a birth weight
      of 650 g, at Delma Island Community Hospital, United Arab Emirates. Despite the
      comparatively limited facilities for such a resuscitation, the rapid ethical
      decisions made when considering the resuscitation of such a borderline viable
      fetus, were key in avoiding long term neurological and pulmonary problems and
      contributed to the outcome of a healthy infant.
FAU - Saeed, Zahra'a Mohamed
AU  - Saeed ZM
AD  - Departments of Anesthesiology & ICU and.
FAU - Shubbar, Imad Ibrahim
AU  - Shubbar II
LA  - eng
PT  - Journal Article
DEP - 20120715
PL  - Oman
TA  - Sultan Qaboos Univ Med J
JT  - Sultan Qaboos University medical journal
JID - 101519915
PMC - PMC3413630
OTO - NOTNLM
OT  - Infant, extremely low birth weight
OT  - Infant, very low birth weight
OT  - Respiratory distress syndrome, newborn
EDAT- 2012/08/23 06:00
MHDA- 2012/08/23 06:01
CRDT- 2012/08/23 06:00
PHST- 2011/09/20 00:00 [received]
PHST- 2012/04/02 00:00 [revised]
PHST- 2012/04/30 00:00 [revised]
PHST- 2012/05/14 00:00 [accepted]
PHST- 2012/08/23 06:00 [entrez]
PHST- 2012/08/23 06:00 [pubmed]
PHST- 2012/08/23 06:01 [medline]
PST - ppublish
SO  - Sultan Qaboos Univ Med J. 2012 Aug;12(3):364-8. Epub 2012 Jul 15.


PMID- 22912776
OWN - NLM
STAT- MEDLINE
DCOM- 20130501
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 8
DP  - 2012
TI  - Glass shape influences consumption rate for alcoholic beverages.
PG  - e43007
LID - 10.1371/journal.pone.0043007 [doi]
AB  - BACKGROUND: High levels of alcohol consumption and increases in heavy episodic
      drinking (binge drinking) are a growing public concern, due to their association 
      with increased risk of personal and societal harm. Alcohol consumption has been
      shown to be sensitive to factors such as price and availability. The aim of this 
      study was to explore the influence of glass shape on the rate of consumption of
      alcoholic and non-alcoholic beverages. METHODS: This was an experimental design
      with beverage (lager, soft drink), glass (straight, curved) and quantity (6 fl
      oz, 12 fl oz) as between-subjects factors. Social male and female alcohol
      consumers (n = 159) attended two experimental sessions, and were randomised to
      drink either lager or a soft drink from either a curved or straight-sided glass, 
      and complete a computerised task identifying perceived midpoint of the two
      glasses (order counterbalanced). Ethical approval was granted by the Faculty of
      Science Research Ethics Committee at the University of Bristol. The primary
      outcome measures were total drinking time of an alcoholic or non-alcoholic
      beverage, and perceptual judgement of the half-way point of a straight and curved
      glass. RESULTS: Participants were 60% slower to consume an alcoholic beverage
      from a straight glass compared to a curved glass. This effect was only observed
      for a full glass and not a half-full glass, and was not observed for a
      non-alcoholic beverage. Participants also misjudged the half-way point of a
      curved glass to a greater degree than that of a straight glass, and there was a
      trend towards a positive association between the degree of error and total
      drinking time. CONCLUSIONS: Glass shape appears to influence the rate of drinking
      of alcoholic beverages. This may represent a modifiable target for public health 
      interventions.
FAU - Attwood, Angela S
AU  - Attwood AS
AD  - School of Experimental Psychology, University of Bristol, Bristol, United
      Kingdom. angela.attwood@bristol.ac.uk
FAU - Scott-Samuel, Nicholas E
AU  - Scott-Samuel NE
FAU - Stothart, George
AU  - Stothart G
FAU - Munafo, Marcus R
AU  - Munafo MR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120817
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Alcohol Drinking/*psychology
MH  - Beer
MH  - *Cooking and Eating Utensils
MH  - Female
MH  - Humans
MH  - Male
MH  - Time Factors
PMC - PMC3422221
EDAT- 2012/08/23 06:00
MHDA- 2013/05/02 06:00
CRDT- 2012/08/23 06:00
PHST- 2012/04/03 00:00 [received]
PHST- 2012/07/16 00:00 [accepted]
PHST- 2012/08/23 06:00 [entrez]
PHST- 2012/08/23 06:00 [pubmed]
PHST- 2013/05/02 06:00 [medline]
AID - 10.1371/journal.pone.0043007 [doi]
AID - PONE-D-12-09889 [pii]
PST - ppublish
SO  - PLoS One. 2012;7(8):e43007. doi: 10.1371/journal.pone.0043007. Epub 2012 Aug 17.


PMID- 22912391
OWN - NLM
STAT- MEDLINE
DCOM- 20130520
LR  - 20151119
IS  - 1557-3265 (Electronic)
IS  - 1078-0432 (Linking)
VI  - 18
IP  - 23
DP  - 2012 Dec 1
TI  - Publication and reporting conduct for pharmacodynamic analyses of tumor tissue in
      early-phase oncology trials.
PG  - 6478-84
LID - 10.1158/1078-0432.CCR-12-1384 [doi]
AB  - PURPOSE: In principle, nondiagnostic biopsies for pharmacodynamic (PD) studies
      are carried out to inform decision-making in drug development. Because such
      procedures have no therapeutic value, their ethical justification requires that
      results be published. We aimed to assess the frequency of nonpublication of PD
      data in early phase cancer trials and to identify factors that prevent full
      publication of data. METHODS: We identified a sample of early-phase cancer trials
      containing invasive nondiagnostic tissue procurement for PD analysis from
      American Society of Clinical Oncology and American Association for Cancer
      Research meeting abstracts published between 1995 and 2005. These trials were
      followed to publication to determine frequency of nonpublication of PD data.
      Corresponding authors on early-phase cancer trials using invasive nondiagnostic
      research procedures were also surveyed to identify factors preventing full
      publication of PD data. RESULTS: In a sample of 90 trials, 22.2% (20 trials)
      resulted in no trial publication. Of published trials expected to contain PD
      reports, 16 (17.8%) did not include any PD data, and 21 (23.3%) reported
      incomplete PD data. We surveyed 92 authors; nonpublication was regarded as a
      frequent occurrence, and the most commonly cited barrier to full publication of
      PD data was strategic considerations in publication (58.8% of responding
      authors). CONCLUSIONS: Our results suggest ways that investigators, study
      planners, and reviewers can improve the burden/knowledge value balance in PD
      studies.
CI  - (c)2012 AACR.
FAU - Freeman, Georgina A
AU  - Freeman GA
AD  - Biomedical Ethics Unit, Department of Experimental Medicine, Department of Social
      Studies of Medicine, McGill University, Montreal, Quebec, Canada.
FAU - Kimmelman, Jonathan
AU  - Kimmelman J
LA  - eng
GR  - EOG 102823/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120821
PL  - United States
TA  - Clin Cancer Res
JT  - Clinical cancer research : an official journal of the American Association for
      Cancer Research
JID - 9502500
RN  - 0 (Antineoplastic Agents)
SB  - IM
CIN - Clin Cancer Res. 2012 Dec 1;18(23):6398-9. PMID: 23052254
MH  - Antineoplastic Agents/*pharmacology
MH  - Biopsy/ethics
MH  - Clinical Trials as Topic/standards
MH  - Humans
MH  - Neoplasms/pathology
MH  - *Publications/standards/statistics & numerical data
MH  - *Research Report/standards
MH  - Surveys and Questionnaires
EDAT- 2012/08/23 06:00
MHDA- 2013/05/22 06:00
CRDT- 2012/08/23 06:00
PHST- 2012/08/23 06:00 [entrez]
PHST- 2012/08/23 06:00 [pubmed]
PHST- 2013/05/22 06:00 [medline]
AID - 1078-0432.CCR-12-1384 [pii]
AID - 10.1158/1078-0432.CCR-12-1384 [doi]
PST - ppublish
SO  - Clin Cancer Res. 2012 Dec 1;18(23):6478-84. doi: 10.1158/1078-0432.CCR-12-1384.
      Epub 2012 Aug 21.


PMID- 22911410
OWN - NLM
STAT- MEDLINE
DCOM- 20121231
LR  - 20190911
IS  - 1984-0446 (Electronic)
IS  - 0034-7167 (Linking)
VI  - 65
IP  - 2
DP  - 2012 Mar-Apr
TI  - [Ethical dilemmas in ICU: contributions of Max Scheler's Theory of Values].
PG  - 276-84
LID - S0034-71672012000200012 [pii]
AB  - The study aimed to reflect, based on the theoretical framework of Max Scheler,
      about the ethical dilemmas experienced by nurses in the ICU, and about the values
      that guide their actions and decisions,. This is qualitative research, and ten
      ICU nurses have been interviewed at a university hospital. It was identified the 
      experience of ethical dilemmas related to the terminality related to the limits
      of intervention and use of material resources, as well as the issue of blood
      transfusion in case of religious restrictions. The values identified were:
      respect, dignity of the patient, scientific knowledge, humility, passion for the 
      profession and love of God. The theory of values is an important tool for nursing
      because it allows the approach of an ethics of humanizing praxis, especially in
      situations of ethical dilemmas.
FAU - Medeiros, Marlise Barros de
AU  - Medeiros MB
AD  - Programa de Residencia em Enfermagem em Oncologia, Instituto Nacional do Cancer, 
      Rio de Janeiro, RJ, Brazil.
FAU - Pereira, Eliane Ramos
AU  - Pereira ER
FAU - Silva, Rose Mary Costa Rosa Andrade
AU  - Silva RM
FAU - Silva, Marcos Andrade
AU  - Silva MA
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Dilemas eticos em UTI: contribuicoes da Teoria dos Valores de Max Scheler.
PL  - Brazil
TA  - Rev Bras Enferm
JT  - Revista brasileira de enfermagem
JID - 7910105
MH  - *Ethics, Nursing
MH  - Humans
MH  - Intensive Care Units/*ethics
EDAT- 2012/08/23 06:00
MHDA- 2013/01/01 06:00
CRDT- 2012/08/23 06:00
PHST- 2010/09/28 00:00 [received]
PHST- 2012/04/12 00:00 [accepted]
PHST- 2012/08/23 06:00 [entrez]
PHST- 2012/08/23 06:00 [pubmed]
PHST- 2013/01/01 06:00 [medline]
AID - S0034-71672012000200012 [pii]
AID - 10.1590/s0034-71672012000200012 [doi]
PST - ppublish
SO  - Rev Bras Enferm. 2012 Mar-Apr;65(2):276-84. doi: 10.1590/s0034-71672012000200012.


PMID- 22911232
OWN - NLM
STAT- MEDLINE
DCOM- 20140717
LR  - 20120822
IS  - 2567-5834 (Electronic)
IS  - 1434-1220 (Linking)
VI  - 40
IP  - 4
DP  - 2012
TI  - [Accuracy and repeatability of clinical examinations postpartum in dairy cattle].
PG  - 251-4
AB  - A variety of diagnostic tests are utilized during herd health examinations at the
      herd and individual cow level. While most of these tests are based on the best
      available evidence it has to be considered that each diagnostic test generates
      type 1 and 2 errors. Such diagnostic errors can lead to treatment errors with
      relevant clinical and pharmacological as well as ethical and economical
      consequences. The objectives of our studies were to generate science-based
      information on the repeatability and accuracy of relevant diagnostic methods
      utilized in postpartum monitoring of dairy cows. Both rectal thermometry and
      visual examination of vaginal discharge by means of a speculum are not perfect.
      Results can be biased by a variety of factors. Diagnostic performance (accuracy
      and repeatability), however, is adequate for cow side tests in the practice. The 
      visual assessment of rumen fill is an inadequate method to monitor dry matter
      intake in cows.
FAU - Heuwieser, W
AU  - Heuwieser W
AD  - Tierklinik fur Fortpflanzung, Fachbereich Veterinarmedizin, Freie Universitat
      Berlin, Konigsweg 65, 14163 Berlin. w.heuwieser@fu-berlin.de
FAU - Burfeind, O
AU  - Burfeind O
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Studien zur Genauigkeit postpartaler Untersuchungen beim Rind.
PL  - Germany
TA  - Tierarztl Prax Ausg G Grosstiere Nutztiere
JT  - Tierarztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
JID - 9715779
SB  - IM
MH  - Animals
MH  - Body Temperature
MH  - Cattle/*anatomy & histology/*physiology
MH  - Diagnostic Errors/veterinary
MH  - Diagnostic Tests, Routine/standards/*veterinary
MH  - Eating
MH  - Gynecological Examination/standards/veterinary
MH  - Physical Examination/standards/*veterinary
MH  - *Postpartum Period/physiology
MH  - Rumen/physiology
MH  - Surgical Instruments/standards/veterinary
MH  - Thermometers/standards/veterinary
MH  - Thermometry/veterinary
EDAT- 2012/08/23 06:00
MHDA- 2014/07/18 06:00
CRDT- 2012/08/23 06:00
PHST- 2012/05/03 00:00 [received]
PHST- 2012/06/19 00:00 [accepted]
PHST- 2012/08/23 06:00 [entrez]
PHST- 2012/08/23 06:00 [pubmed]
PHST- 2014/07/18 06:00 [medline]
AID - 12040251 [pii]
PST - ppublish
SO  - Tierarztl Prax Ausg G Grosstiere Nutztiere. 2012;40(4):251-4.


PMID- 22911055
OWN - NLM
STAT- MEDLINE
DCOM- 20121116
LR  - 20211021
IS  - 1549-1676 (Electronic)
IS  - 1549-1277 (Linking)
VI  - 9
IP  - 7
DP  - 2012
TI  - United States private-sector physicians and pharmaceutical contract research: a
      qualitative study.
PG  - e1001271
LID - 10.1371/journal.pmed.1001271 [doi]
AB  - BACKGROUND: There have been dramatic increases over the past 20 years in the
      number of nonacademic, private-sector physicians who serve as principal
      investigators on US clinical trials sponsored by the pharmaceutical industry.
      However, there has been little research on the implications of these
      investigators' role in clinical investigation. Our objective was to study
      private-sector clinics involved in US pharmaceutical clinical trials to
      understand the contract research arrangements supporting drug development, and
      specifically how private-sector physicians engaged in contract research describe 
      their professional identities. METHODS AND FINDINGS: We conducted a qualitative
      study in 2003-2004 combining observation at 25 private-sector research
      organizations in the southwestern United States and 63 semi-structured interviews
      with physicians, research staff, and research participants at those clinics. We
      used grounded theory to analyze and interpret our data. The 11 private-sector
      physicians who participated in our study reported becoming principal
      investigators on industry clinical trials primarily because contract research
      provides an additional revenue stream. The physicians reported that they saw
      themselves as trial practitioners and as businesspeople rather than as scientists
      or researchers. CONCLUSIONS: Our findings suggest that in addition to having
      financial motivation to participate in contract research, these US private-sector
      physicians have a professional identity aligned with an industry-based approach
      to research ethics. The generalizability of these findings and whether they have 
      changed in the intervening years should be addressed in future studies. Please
      see later in the article for the Editors' Summary.
FAU - Fisher, Jill A
AU  - Fisher JA
AD  - Center for Biomedical Ethics & Society, Vanderbilt University, Nashville,
      Tennessee, United States of America. jill.fisher@vanderbilt.edu
FAU - Kalbaugh, Corey A
AU  - Kalbaugh CA
LA  - eng
GR  - F31 MH070222/MH/NIMH NIH HHS/United States
GR  - 5F31MH070222/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120724
PL  - United States
TA  - PLoS Med
JT  - PLoS medicine
JID - 101231360
SB  - IM
MH  - Contracts/economics/ethics/*legislation & jurisprudence
MH  - Drug Industry/economics/ethics/*legislation & jurisprudence
MH  - Humans
MH  - Motivation
MH  - Physicians/ethics/*legislation & jurisprudence
MH  - Private Sector/economics/ethics/*legislation & jurisprudence
MH  - *Qualitative Research
MH  - United States
PMC - PMC3404112
EDAT- 2012/08/23 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/08/23 06:00
PHST- 2011/11/17 00:00 [received]
PHST- 2012/06/12 00:00 [accepted]
PHST- 2012/08/23 06:00 [entrez]
PHST- 2012/08/23 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1371/journal.pmed.1001271 [doi]
AID - PMEDICINE-D-11-00928 [pii]
PST - ppublish
SO  - PLoS Med. 2012;9(7):e1001271. doi: 10.1371/journal.pmed.1001271. Epub 2012 Jul
      24.


PMID- 22910192
OWN - NLM
STAT- MEDLINE
DCOM- 20121210
LR  - 20191210
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 75
IP  - 11
DP  - 2012 Dec
TI  - The politics of action research: "if you don't like the way things are going, get
      off the bus".
PG  - 1946-53
LID - 10.1016/j.socscimed.2012.06.024 [doi]
LID - S0277-9536(12)00532-1 [pii]
AB  - Participatory action research is lauded for its emancipatory potential and
      practice relevance. Little research has focused on the ethical and political
      dimensions of power relations between management gatekeepers and staff in large
      organizations in the negotiation of action research. To illuminate the dynamics
      of this engagement, this paper is informed by Aristotle's practical ethics of
      phronesis, arguing that ethics emerge through human interaction. The paper
      reports on a multi-method study and intervention in inter-professional learning
      and collaboration, conducted between 2008 and 2010, across an Australian health
      system. It draws on results from researchers' progress notes, 139 semi-structured
      interviews and focus groups (492 participants), more than 200 h of organizational
      document analysis, and more than 200 h of ethnographic observation. From
      conventional thematic analysis, we note that the project had considerable support
      from senior managers who were gatekeepers for the research. Such support stemmed 
      from managerialist tendencies, with senior managers explicitly aligning
      inter-professionalism with prospective health reforms and improvements to quality
      of care and patient safety. Senior managers were also enthusiastic about
      standardized processes. Many frontline staff were less supportive, and some were 
      suspicious of or hostile towards management-led processes to improve and evaluate
      care. Some senior managers' self perceived alignment with and support for the
      research process changed to resistance once this finding was presented. This
      paradox in the interplay of research findings and research process evinces the
      inherent tension between organizational politics and conducting action research
      that reflexive researchers need to negotiate in knowledge translation, exchange
      or mobilization exercises.
CI  - Copyright (c) 2012. Published by Elsevier Ltd.
FAU - Nugus, Peter
AU  - Nugus P
AD  - Centre for Clinical Governance Research, Australian Institute of Health
      Innovation, Faculty of Medicine, University of New South Wales, Australia.
      p.nugus@unsw.edu.au
FAU - Greenfield, David
AU  - Greenfield D
FAU - Travaglia, Joanne
AU  - Travaglia J
FAU - Braithwaite, Jeffrey
AU  - Braithwaite J
LA  - eng
PT  - Journal Article
DEP - 20120801
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Community Participation
MH  - Focus Groups
MH  - Health Services Research/*ethics
MH  - Humans
MH  - *Interprofessional Relations
MH  - Negotiating
MH  - *Politics
MH  - *Power, Psychological
MH  - Qualitative Research
EDAT- 2012/08/23 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/08/23 06:00
PHST- 2011/05/18 00:00 [received]
PHST- 2012/04/04 00:00 [revised]
PHST- 2012/06/27 00:00 [accepted]
PHST- 2012/08/23 06:00 [entrez]
PHST- 2012/08/23 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - S0277-9536(12)00532-1 [pii]
AID - 10.1016/j.socscimed.2012.06.024 [doi]
PST - ppublish
SO  - Soc Sci Med. 2012 Dec;75(11):1946-53. doi: 10.1016/j.socscimed.2012.06.024. Epub 
      2012 Aug 1.


PMID- 22908943
OWN - NLM
STAT- MEDLINE
DCOM- 20130214
LR  - 20181201
IS  - 2152-4998 (Electronic)
IS  - 2152-4971 (Linking)
VI  - 14
IP  - 5
DP  - 2012 Oct
TI  - Stemness of human Wharton's jelly mesenchymal cells is maintained by floating
      cultivation.
PG  - 448-55
LID - 10.1089/cell.2012.0020 [doi]
AB  - Abstract Recently, the search for stem cells has become focused on fetal
      appendages such as the amniotic membrane and umbilical cord. Previously, we have 
      shown the existence of stem cells in the amniotic membrane that can differentiate
      into various cells. In this study, we attempt to characterize and maintain the
      stemness characteristics of mesenchymal stem cells (MSCs) for Wharton's jelly, an
      inherent tissue of the umbilical cord. Wharton's jelly cells (WJCs) were
      isolated, adhered to culture plates, and characterized for stem cell and surface 
      markers expression. They expressed the embryonic stem cell markers Nanog, Oct
      (3/4), and Sox2. On flow cytometric analysis, WJCs predominantly expressed the
      MSC markers CD73, CD90, and CD105 and did not express the hematopoietic lineage
      markers CD14, CD34, CD45, and HLA-DR. In floating culture, WJCs could maintain
      stemness, and they could differentiate to osteogenic, chondrogenic, and
      adipogenic lineages. In conclusion, WJCs satisfy the criteria of MSCs. Given that
      extraction of the umbilical cord is not invasive, and the umbilical cord can be
      obtained without ethical and technical issues, we suggest that WJCs, after
      maintaining stemness, have a potential contribution to medical treatment for
      patients, even newborns, with congenital skeletal and cartilage disorders.
FAU - Higuchi, Osamu
AU  - Higuchi O
AD  - Department of Regenerative Medicine, University of Toyama Graduate School of
      Medicine and Pharmaceutical Sciences, Toyama, Japan.
FAU - Okabe, Motonori
AU  - Okabe M
FAU - Yoshida, Toshiko
AU  - Yoshida T
FAU - Fathy, Moustafa
AU  - Fathy M
FAU - Saito, Shigeru
AU  - Saito S
FAU - Miyawaki, Toshio
AU  - Miyawaki T
FAU - Nikaido, Toshio
AU  - Nikaido T
LA  - eng
PT  - Journal Article
DEP - 20120821
PL  - United States
TA  - Cell Reprogram
JT  - Cellular reprogramming
JID - 101528176
RN  - 0 (Antigens, CD)
RN  - 0 (Biomarkers)
RN  - 0 (DNA Primers)
SB  - IM
MH  - Antigens, CD/immunology/metabolism
MH  - Base Sequence
MH  - Biomarkers/metabolism
MH  - Cells, Cultured
MH  - DNA Primers
MH  - Flow Cytometry
MH  - Humans
MH  - Immunohistochemistry
MH  - Mesenchymal Stem Cells/*cytology/immunology/metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
EDAT- 2012/08/23 06:00
MHDA- 2013/02/15 06:00
CRDT- 2012/08/23 06:00
PHST- 2012/08/23 06:00 [entrez]
PHST- 2012/08/23 06:00 [pubmed]
PHST- 2013/02/15 06:00 [medline]
AID - 10.1089/cell.2012.0020 [doi]
PST - ppublish
SO  - Cell Reprogram. 2012 Oct;14(5):448-55. doi: 10.1089/cell.2012.0020. Epub 2012 Aug
      21.


PMID- 22908743
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20170203
IS  - 0723-1393 (Print)
IS  - 0723-1393 (Linking)
VI  - 31
IP  - 1
DP  - 2012 Mar
TI  - Nurses' knowledge, attitudes and willingness to participate officially in
      workplace Healthcare Ethics Committees (HEC).
PG  - 163-76
AB  - This research was designed to assess nurses' perceptions, knowledge, attitudes
      and intentions in relation to nurse participation in Healthcare Ethics Committees
      (HECs). A convenience sample of 87 nurses from five Israeli hospitals completed a
      self-administered questionnaire, whose data were then analyzed by quantitative
      statistics. The main findings were that large percentages of nurses were totally 
      ignorant of the existence and functioning of the HEC in their workplaces. Nurses 
      in managerial roles were (a) much more knowledgeable on these matters than staff 
      nurses and (b) regarded more positively the idea that nurses had an obligation to
      sit on such committees. Workplace role and rank in the organizational hierarchy
      had a stronger impact on nurse attitudes to HEC work than level of education.
      Overall, nurse willingness to sit on an HEC and to take special training in
      preparation for such a role were high.
FAU - Rubinstein, Dorit
AU  - Rubinstein D
AD  - Department of Nursing, Zefat Academic College, Israel. dorub@hotmail.com
FAU - Tabak, Nili
AU  - Tabak N
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Law
JT  - Medicine and law
JID - 8218185
SB  - IM
MH  - Adult
MH  - *Ethics Committees, Clinical
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Israel
MH  - Male
MH  - Middle Aged
MH  - *Nursing Staff, Hospital
MH  - Sampling Studies
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2012/08/23 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/08/23 06:00
PHST- 2012/08/23 06:00 [entrez]
PHST- 2012/08/23 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
PST - ppublish
SO  - Med Law. 2012 Mar;31(1):163-76.


PMID- 22908742
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20181201
IS  - 0723-1393 (Print)
IS  - 0723-1393 (Linking)
VI  - 31
IP  - 1
DP  - 2012 Mar
TI  - The issue of surrogacy in Czech law.
PG  - 153-62
AB  - Surrogacy is thought to be one of the most controversial methods of assisted
      reproduction. It involves cases where a commissioning couple asks a surrogate
      mother to give birth to a child that will be conceived from their egg and sperm
      because the woman from the commissioning couple is not able to bear the child to 
      full term herself. They conclude an agreement where the surrogate mother binds
      herself to terminate all her parental rights to the child immediately after the
      child's birth and to delegate them together with the child to the commissioning
      couple. Ethical dilemmas concerning the issue of surrogacy together with all the 
      possibilities of today's globalised world that enable infertile couples to find
      surrogate mothers abroad in case the legal regulations of their country put a ban
      on it create a space for a legislator to try to find a solution that will avoid
      all the risks and highlight a number of positives on the other hand. A Czech
      legislator is currently trying to find this solution and even though there are
      few children demonstrably born to surrogate mothers in the Czech Republic, the
      whole process of surrogacy still proceeds in a legal vacuum at the moment. We can
      only find the legal definition of a mother of a child as a woman that gives him
      or her birth and a provision of law that makes all the legal acts that evade the 
      law void. Some practical consequences of this situation will be described in the 
      text together with possibilities and the inspiration that comes from foreign
      legal regulations and cases.
FAU - Lojkova, Jana
AU  - Lojkova J
AD  - Faculty of Law, Masaryk University, Brno, Czech Republic. jana.lojkova@centrum.cz
LA  - eng
PT  - Journal Article
PT  - Legal Case
PL  - United States
TA  - Med Law
JT  - Medicine and law
JID - 8218185
SB  - IM
MH  - Czech Republic
MH  - *Ethics, Medical
MH  - Female
MH  - Humans
MH  - Pregnancy
MH  - Surrogate Mothers/*legislation & jurisprudence
EDAT- 2012/08/23 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/08/23 06:00
PHST- 2012/08/23 06:00 [entrez]
PHST- 2012/08/23 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
PST - ppublish
SO  - Med Law. 2012 Mar;31(1):153-62.


PMID- 22908741
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20211203
IS  - 0723-1393 (Print)
IS  - 0723-1393 (Linking)
VI  - 31
IP  - 1
DP  - 2012 Mar
TI  - Ethical, legal and social issues in the context of the planning stages of the
      Southern African Human Genome Programme.
PG  - 119-52
AB  - As the focus on the origin of modern man appears to be moving from eastern to
      southern Africa, it is recognised that indigenous populations in southern Africa 
      may be the most genetically diverse on the planet and hence a valuable resource
      for human genetic diversity studies. In order to build regional capacity for the 
      generation, analysis and application of genomic data, the Southern African Human 
      Genome Programme was recently launched with the aid of seed funding from the
      national Department of Science and Technology in South Africa. The purpose of the
      article is to investigate pertinent ethical, legal and social issues that have
      emerged during the planning stages of the Southern African Human Genome
      Programme. A careful consideration of key issues such as public perception of
      genomic research, issues relating to genetic and genomic discrimination and
      stigmatisation, informed consent, privacy and data protection, and the concept of
      genomic sovereignty, is of paramount importance in the early stages of the
      Programme. This article will also consider the present legal framework governing 
      genomic research in South Africa and will conclude with proposals regarding such 
      a framework for the future.
FAU - de Vries, Jantina
AU  - de Vries J
AD  - Department of Human Genetics, Faculty of Health Sciences, University of Cape
      Town, Cape Town, South Africa. Jantina.devries@uct.ac.za
FAU - Slabbert, Melodie
AU  - Slabbert M
FAU - Pepper, Michael S
AU  - Pepper MS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Law
JT  - Medicine and law
JID - 8218185
SB  - IM
MH  - Ethnicity/genetics
MH  - Genetic Research/ethics
MH  - *Genome, Human
MH  - *Genomics
MH  - Humans
MH  - Information Dissemination/legislation & jurisprudence
MH  - Informed Consent/legislation & jurisprudence
MH  - Prejudice
MH  - South Africa
MH  - Stereotyping
EDAT- 2012/08/23 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/08/23 06:00
PHST- 2012/08/23 06:00 [entrez]
PHST- 2012/08/23 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
PST - ppublish
SO  - Med Law. 2012 Mar;31(1):119-52.


PMID- 22908740
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20181201
IS  - 0723-1393 (Print)
IS  - 0723-1393 (Linking)
VI  - 31
IP  - 1
DP  - 2012 Mar
TI  - Wrongful life and birth.
PG  - 97-118
AB  - The main scope of the article is the bioethical and legal issues of wrongful
      birth and wrongful life with reference to doctors' medical liability. Nowadays,
      prenatal tests tend to substitute the eugenic practice of Spartan inspection to
      raise a strong and healthy child. Should the doctor misinform the parents that
      the child is healthy and the parents do not exercise the right to abort the
      pregnancy, the doctor can be held liable and claims on wrongful life or birth are
      raised against him. "Wrongful life" is an oxymoron itself since "life" which has 
      an intrinsic value and sanctity is attributed a negative aspect and is regarded
      as damage. Courts around the world have awarded parents compensation on that
      legal ground. In the Perruche affair (2000), where the mother was wrongly
      diagnosed and gave birth to Nicholas, who had serious neurological problems, the 
      court conferred the right on the child itself, causing an uproar in France. The
      decision was criticized for encouraging eugenics and diminishing the value of
      handicapped people. The different approaches to the above issues by different
      courts around the world (US, EU) with reference to (bio) ethical concerns are
      going to be examined. We will try to give an answer on whether it is possible for
      courts to support on legal and bioethical grounds that a child with disabilities 
      should not have been born as a result of the doctor's negligent conduct. In such 
      cases, the limits of normality and the value of life are challenged
FAU - Evgenia, Smyrnaki
AU  - Evgenia S
AD  - University of Athens. jenny_smyrnak@yahoo.gr
LA  - eng
PT  - Journal Article
PT  - Legal Case
PL  - United States
TA  - Med Law
JT  - Medicine and law
JID - 8218185
SB  - IM
MH  - Abortion, Induced/legislation & jurisprudence
MH  - Compensation and Redress/*legislation & jurisprudence
MH  - Female
MH  - Humans
MH  - *Liability, Legal
MH  - Malpractice/*legislation & jurisprudence
MH  - Pregnancy
MH  - Prenatal Diagnosis
MH  - *Wrongful Life
EDAT- 2012/08/23 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/08/23 06:00
PHST- 2012/08/23 06:00 [entrez]
PHST- 2012/08/23 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
PST - ppublish
SO  - Med Law. 2012 Mar;31(1):97-118.


PMID- 22908737
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20170203
IS  - 0723-1393 (Print)
IS  - 0723-1393 (Linking)
VI  - 31
IP  - 1
DP  - 2012 Mar
TI  - Patient's rights in Poland against the background of new regulations.
PG  - 43-56
AB  - Patient rights are the specification of general human rights. The rights define
      the patient position in relation to health institutions or medical professions
      providing, broadly understood, health services. The protection system of patient 
      rights outlined by international legal and ethical regulations is detailed to
      specific social, political and economic realities by internal legal systems of
      individual states. Imperfections of the Polish health care system in relation to 
      achieving adequate protection of patient rights, resulting, inter alia, from the 
      lack of comprehensive regulation of the matter of patient rights, led the
      legislature to introduce new regulations concerning this aspect to the Polish
      legal order. The new Act of 6 November 2008 on Patient Rights and the Patient
      Rights Ombudsman (binding from 5 March 2009) is the first universally binding
      legal act in the Polish legal system entirely dealing with the matter of patient 
      rights. It regulates the rights of the patient and correlated with them
      obligations of health care providers (public and non-public) irrespectively of
      both the legal form providers, as well as the sources of funding of the benefits 
      provided. In particular, the Act states: the patient right to health services,
      right to obtain information, right to confidentiality of patient-linked
      information, right to consent to obtain health services, right to respect privacy
      and dignity of the patients, right to medical records and objecting to the
      doctor's opinion or decision, right to respect private and family life, right to 
      pastoral care. The new regulations--besides the specification of the catalogue of
      patient rights--reinforced the institutional protection of patient rights by
      establishing a new central public administrative body having jurisdiction to
      protect patient rights--the Patient Rights Ombudsman. Poland, like other European
      countries, makes an attempt to improve the protection of patient rights. The
      introduction of the Act entirely devoted to patient rights is undoubtedly an
      important step towards creating the optimum protection of the patient.
FAU - Rabiega-Przylecka, Agnieszka
AU  - Rabiega-Przylecka A
AD  - University Of Lodz, Faculty of Law and Administration, ul. Kopcinskiego 8/12,
      90-232 Lodz, Poland. a.rabiega@interia.pl
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Law
JT  - Medicine and law
JID - 8218185
SB  - IM
MH  - Humans
MH  - National Health Programs/legislation & jurisprudence
MH  - Patient Rights/*legislation & jurisprudence
MH  - Poland
EDAT- 2012/08/23 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/08/23 06:00
PHST- 2012/08/23 06:00 [entrez]
PHST- 2012/08/23 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
PST - ppublish
SO  - Med Law. 2012 Mar;31(1):43-56.


PMID- 22908614
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20181201
IS  - 1320-159X (Print)
IS  - 1320-159X (Linking)
VI  - 19
IP  - 4
DP  - 2012 Jun
TI  - Epistemology and the ethics of homoeopathy: a response to Freckelton.
PG  - 699-704; author reply 704-6
FAU - Levy, David
AU  - Levy D
FAU - Gadd, Ben
AU  - Gadd B
LA  - eng
PT  - Letter
PT  - Comment
PL  - Australia
TA  - J Law Med
JT  - Journal of law and medicine
JID - 9431853
SB  - IM
CON - J Law Med. 2012 Mar;19(3):454-78. PMID: 22558899
MH  - Homeopathy/*legislation & jurisprudence
MH  - Humans
MH  - Malpractice/*legislation & jurisprudence
EDAT- 2012/08/23 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/08/23 06:00
PHST- 2012/08/23 06:00 [entrez]
PHST- 2012/08/23 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
PST - ppublish
SO  - J Law Med. 2012 Jun;19(4):699-704; author reply 704-6.


PMID- 22908611
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20181201
IS  - 1320-159X (Print)
IS  - 1320-159X (Linking)
VI  - 19
IP  - 4
DP  - 2012 Jun
TI  - The evolution of informed consent.
PG  - 673-7
AB  - Informed consent and the changes in what is expected over the 21st century
      provide an instructive case study of the mutual influence on one another of
      medical law and medical ethics. Over the years we have moved from a
      doctor-centred standard to a patient-centred standard and from a
      one-size-fits-all patient-centred standard to a more individual requirement that 
      engages with the needs of a particular patient It is unreasonable to expect those
      changes to be reflected in anything less than an extended conversation in which
      the health care professional gives out some version of what a reasonable patient 
      would expect to hear from an informed health care professional and then responds 
      to the patient's questions as informatively and helpfully as he or she can. It is
      therefore convenient to refer to spontaneous and responsive disclosure as a very 
      concrete implementation of the health care professional-patient partnership that 
      is contemporary health care and at the heart of health care ethics.
FAU - Gillett, Grant
AU  - Gillett G
AD  - Dunedin Hospital and Otago Bioethics Centre, University of Otago Medical School, 
      New Zealand. grant.gillett@stonebow.otago.ac.nz
FAU - Walker, Simon
AU  - Walker S
LA  - eng
PT  - Journal Article
PT  - Legal Case
PL  - Australia
TA  - J Law Med
JT  - Journal of law and medicine
JID - 9431853
SB  - IM
MH  - Bioethical Issues
MH  - Decision Making
MH  - Disclosure/legislation & jurisprudence
MH  - Humans
MH  - Informed Consent/*legislation & jurisprudence
MH  - Physician-Patient Relations
EDAT- 2012/08/23 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/08/23 06:00
PHST- 2012/08/23 06:00 [entrez]
PHST- 2012/08/23 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
PST - ppublish
SO  - J Law Med. 2012 Jun;19(4):673-7.


PMID- 22908526
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20191112
IS  - 0929-0273 (Print)
IS  - 0929-0273 (Linking)
VI  - 19
IP  - 4
DP  - 2012 Sep
TI  - End-of-life healthcare decisions, ethics and law: the debate in Spain.
PG  - 355-65
AB  - The debate on euthanasia in Spain has been ongoing from the beginning of the 20th
      century and remains extant. Three periods can be identified: prior to 1978,
      1978-2002, and after 2002. The debate increased significantly after the Ramon
      Sampedro case (1995-1998), and was fuelled with new, although very different
      cases, such as those of Leganes (2005-2008), Jorge Leon (2006) or Inmaculada
      Echevarria (2006-2007). As a consequence of these cases in 2008 the Regional
      Government of Andalusia started a legal process to pass a law regulating
      end-of-life decisions, excluding euthanasia and assisted-suicide, which was
      finally enacted in 2010. Two other Spanish regions (Navarra and Aragon) passed
      similar laws. The central government also initiated a legal process to approve a 
      national law, excluding euthanasia and assisted-suicide. The project failed
      because of the dissolution of the Parliament in June 2011. The new government
      will have to decide how to continue the process.
FAU - Simon-Lorda, Pablo
AU  - Simon-Lorda P
AD  - Andalusian School of Public Health, Granada, Spain.
      pablo.simon.easp@juntadeandalucia.es
FAU - Barrio-Cantalejo, Ines M
AU  - Barrio-Cantalejo IM
LA  - eng
PT  - Journal Article
PT  - Legal Case
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur J Health Law
JT  - European journal of health law
JID - 9431861
SB  - IM
MH  - Euthanasia/*ethics/*legislation & jurisprudence
MH  - Humans
MH  - Spain
MH  - Suicide, Assisted/*ethics/*legislation & jurisprudence
EDAT- 2012/08/23 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/08/23 06:00
PHST- 2012/08/23 06:00 [entrez]
PHST- 2012/08/23 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
AID - 10.1163/157180912x651419 [doi]
PST - ppublish
SO  - Eur J Health Law. 2012 Sep;19(4):355-65. doi: 10.1163/157180912x651419.


PMID- 22908488
OWN - NLM
STAT- MEDLINE
DCOM- 20120925
LR  - 20120822
IS  - 0198-7097 (Print)
IS  - 0198-7097 (Linking)
VI  - 34
IP  - 4
DP  - 2012 Jul-Aug
TI  - The need for an effective compliance program.
PG  - 29-32; quiz 34-5
AB  - Recent healthcare related law, and more importantly, government enforcement
      activity of the law is increasing at an exponential rate. Many imaging exams are 
      quite expensive and represent a significant portion of claims paid to
      beneficiaries of Medicare and Medicaid programs. While many large healthcare
      organizations have well-honed compliance and ethics programs and infrastructures,
      small to medium sized organizations are especially at risk for ethical misconduct
      and subsequent sanction by the Federal Sentencing Guidelines for Organizations.
      Creating of a culture of compliance starts at the highest level of an
      organization and is disseminated via a well defined executive document and
      communicated during new hire orientation and continual management through staff
      meetings and training.
FAU - Hayes, Jeff
AU  - Hayes J
AD  - GateWay Community College, Phoenix, AZ, USA. jhayes@hcspsc.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Radiol Manage
JT  - Radiology management
JID - 8001971
MH  - Education, Continuing
MH  - *Facility Regulation and Control
MH  - *Guideline Adherence
MH  - Radiology Department, Hospital/economics/*legislation & jurisprudence
MH  - United States
EDAT- 2012/08/23 06:00
MHDA- 2012/09/26 06:00
CRDT- 2012/08/23 06:00
PHST- 2012/08/23 06:00 [entrez]
PHST- 2012/08/23 06:00 [pubmed]
PHST- 2012/09/26 06:00 [medline]
PST - ppublish
SO  - Radiol Manage. 2012 Jul-Aug;34(4):29-32; quiz 34-5.


PMID- 22907696
OWN - NLM
STAT- MEDLINE
DCOM- 20130606
LR  - 20121116
IS  - 1661-7819 (Electronic)
IS  - 1661-7800 (Linking)
VI  - 102
IP  - 4
DP  - 2012
TI  - A case of compound mutations in the MYBPC3 gene associated with biventricular
      hypertrophy and neonatal death.
PG  - 254-8
LID - 10.1159/000339847 [doi]
AB  - Hypertrophic cardiomyopathy (HCM) is a familial, genetically determined, primary 
      cardiomyopathy caused by mutations in genes coding for proteins of the sarcomere,
      or, less frequently, genes involved in storage diseases. In pediatric settings,
      pure HCM has an estimated incidence of 4.7 per million children. The disease is
      often sub-clinical and goes unrecognized mainly because most patients with HCM
      have only mild symptoms, if any. However, sudden cardiac death, the most dramatic
      clinical occurrence and the primary concern for patients and physicians alike,
      may be the first manifestation of the disease. We describe a case of compound
      heterozygosity in the MYBPC3 gene (p.Glu258Lys and IVS25-1G>A) associated with
      biventricular hypertrophy, atrial enlargement and subsequent neonatal death 33
      days postpartum. Other studies have reported compound and/or double heterozygosis
      in the same or different sarcomeric genes during childhood and adulthood, and
      neonatal presentations have also been described. Our observations show that the
      combination of a missense (p.Glu258Lys) and a splice-site mutation (IVS25-1G>A)
      profoundly affects the clinical course. In families in which parental mutations
      are known, preimplantation (where ethically and legally feasible) or prenatal
      genetic screening should be adopted because: (1) neonatal HCM in genetic
      heterozygosity is potentially lethal and (2) heart disease is the most common
      developmental malformation and the leading cause of neonatal mortality and
      morbidity.
CI  - Copyright (c) 2012 S. Karger AG, Basel.
FAU - Marziliano, Nicola
AU  - Marziliano N
AD  - Pathology Department, AO Ospedale Ca Granda Niguarda, Milan, Italy.
      nicola.marziliano@ospedaleniguarda.it
FAU - Merlini, Piera Angelica
AU  - Merlini PA
FAU - Vignati, Gabriele
AU  - Vignati G
FAU - Orsini, Francesco
AU  - Orsini F
FAU - Motta, Valentina
AU  - Motta V
FAU - Bandiera, Laura
AU  - Bandiera L
FAU - Intrieri, Mariano
AU  - Intrieri M
FAU - Veronese, Silvio
AU  - Veronese S
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120817
PL  - Switzerland
TA  - Neonatology
JT  - Neonatology
JID - 101286577
RN  - 0 (Carrier Proteins)
RN  - 0 (RNA Splice Sites)
RN  - 0 (myosin-binding protein C)
SB  - IM
MH  - Cardiomyopathy, Hypertrophic, Familial/*genetics/mortality
MH  - Carrier Proteins/*genetics
MH  - Fatal Outcome
MH  - Female
MH  - Heterozygote
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - *Mutation, Missense
MH  - Pedigree
MH  - RNA Splice Sites/*genetics
EDAT- 2012/08/22 06:00
MHDA- 2013/06/07 06:00
CRDT- 2012/08/22 06:00
PHST- 2012/02/06 00:00 [received]
PHST- 2012/06/03 00:00 [accepted]
PHST- 2012/08/22 06:00 [entrez]
PHST- 2012/08/22 06:00 [pubmed]
PHST- 2013/06/07 06:00 [medline]
AID - 000339847 [pii]
AID - 10.1159/000339847 [doi]
PST - ppublish
SO  - Neonatology. 2012;102(4):254-8. doi: 10.1159/000339847. Epub 2012 Aug 17.


PMID- 22906683
OWN - NLM
STAT- MEDLINE
DCOM- 20130422
LR  - 20181202
IS  - 1872-7654 (Electronic)
IS  - 0301-2115 (Linking)
VI  - 165
IP  - 1
DP  - 2012 Nov
TI  - Ethical guidelines and the prevention of abuse in healthcare.
PG  - 18-28
LID - 10.1016/j.ejogrb.2012.07.018 [doi]
LID - S0301-2115(12)00337-5 [pii]
AB  - OBJECTIVE: In obstetrical and gynaecological healthcare, patients often find
      themselves in a vulnerable position. Sensitive issues such as sexual and
      reproductive health are addressed and certain procedures can be experienced as
      abusive. According to research a lifetime prevalence of abuse in healthcare (AHC)
      can be assumed for 13-28% of female patients in the Nordic countries. In the
      present study we analyse the content of ethical documents for healthcare
      professionals within obstetrics and gynaecology in Sweden, in order to find out
      to what extent ethical guidelines consider issues that have shown to be related
      to the occurrence of AHC. STUDY DESIGN: We searched the literature to find
      empirical data on AHC. Guidelines for nurses, midwives and physicians were
      selected. After developing an analytical framework based on the empirical data
      the content of the ethical guidelines was analysed. RESULTS: The various ethical 
      guidelines for staff working within obstetrics and gynaecology differ
      distinctively from each other regarding their content of issues that are related 
      to AHC. Issues that were mostly disregarded were: considering the patient's
      perspective and the patients' possible experience of violence, considering power 
      imbalances within healthcare, sexual misconduct, how to deal with other
      professional's ethical misconduct and how professionals relate to each other. We 
      found the ethical guidelines of the International Federation of Gynecology and
      Obstetrics (FIGO) and of the International Confederation of Midwives to be those 
      which contained most of the issues that have empirically shown to be important in
      regard to AHC. CONCLUSION: While staff members from different professions may
      share responsibility for the same patient, their ethical guidelines vary
      considerably. To become a possible resource for prevention of AHC, we suggest
      that ethical guidelines in healthcare should be revised following empirical
      research on ethical conduct. As ethical guidelines cannot be effective by their
      existence only, we would like to initiate a discussion on the function and use of
      ethical guidelines in general and regarding AHC in particular. Being aware that
      ethical guidelines are only a part of ethics in healthcare, however, we envision 
      a broader approach to the aim of preventing AHC, where research is encouraged on 
      how a virtue ethics approach could be applied.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Zbikowski, Anke
AU  - Zbikowski A
AD  - Division of Gender and Medicine, Department of Clinical and Experimental
      Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden.
      anke.zbikowski@liu.se
FAU - Bruggemann, A Jelmer
AU  - Bruggemann AJ
FAU - Wijma, Barbro
AU  - Wijma B
FAU - Zeiler, Kristin
AU  - Zeiler K
FAU - Swahnberg, Katarina
AU  - Swahnberg K
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120817
PL  - Ireland
TA  - Eur J Obstet Gynecol Reprod Biol
JT  - European journal of obstetrics, gynecology, and reproductive biology
JID - 0375672
SB  - IM
MH  - Female
MH  - Gynecology/ethics
MH  - Health Personnel/ethics
MH  - Humans
MH  - Obstetrics/ethics
MH  - Patient Rights
MH  - Physicians/ethics
MH  - *Practice Guidelines as Topic
MH  - *Professional-Patient Relations
MH  - Quality of Health Care
MH  - Sex Offenses/ethics/*prevention & control
MH  - Sweden
MH  - Violence/ethics/*prevention & control
MH  - Vulnerable Populations
MH  - Women's Health Services/*ethics
MH  - Women's Rights
MH  - Workforce
EDAT- 2012/08/22 06:00
MHDA- 2013/04/23 06:00
CRDT- 2012/08/22 06:00
PHST- 2011/12/31 00:00 [received]
PHST- 2012/05/28 00:00 [revised]
PHST- 2012/07/24 00:00 [accepted]
PHST- 2012/08/22 06:00 [entrez]
PHST- 2012/08/22 06:00 [pubmed]
PHST- 2013/04/23 06:00 [medline]
AID - S0301-2115(12)00337-5 [pii]
AID - 10.1016/j.ejogrb.2012.07.018 [doi]
PST - ppublish
SO  - Eur J Obstet Gynecol Reprod Biol. 2012 Nov;165(1):18-28. doi:
      10.1016/j.ejogrb.2012.07.018. Epub 2012 Aug 17.


PMID- 22906660
OWN - NLM
STAT- MEDLINE
DCOM- 20121231
LR  - 20120913
IS  - 1527-3792 (Electronic)
IS  - 0022-5347 (Linking)
VI  - 188
IP  - 4 Suppl
DP  - 2012 Oct
TI  - Long-term urethral function measured by uroflowmetry after hypospadias surgery:
      comparison with an age matched control.
PG  - 1457-62
LID - 10.1016/j.juro.2012.04.105 [doi]
AB  - PURPOSE: Long-term outcomes of hypospadias surgery, particularly urinary
      function, have not been examined thoroughly. Uroflowmetry can be used to evaluate
      long-term functional outcomes by assessing flow shape and the rate of
      micturition. We assessed urethral function using uroflowmetry in adolescents
      after undergoing hypospadias repair in infancy and compared this with age matched
      controls. MATERIALS AND METHODS: After human research ethics committee approval
      (HREC 28111A), 17 boys 13 to 15 years old with no history of urological or
      neurological disorders underwent uroflowmetry (65 separate voids) to determine
      standard values for boys of this age. Then 60 boys age 13 to 15 years who had
      undergone treatment for hypospadias in early infancy were seen for long-term
      followup and underwent uroflow assessment. RESULTS: Standard urinary flow rates
      were established in the 13 to 15-year-old control group and represented on a
      nomogram. In the boys who underwent hypospadias surgery the urine flow rates were
      significantly lower compared to the control nomogram (p <0.0001), with half the
      patients having uroflow rates below 1 SD from the control mean but without
      symptoms. Boys with significant preoperative chordee were more likely to have
      poorer urinary flow (p <0.04). A poor urinary flow rate also was significantly
      associated with post-void residual bladder volume (p <0.03). There was no
      correlation with original meatal location, number of operations, presence of
      postoperative complications, current anatomy and lower urinary tract symptoms (eg
      post-void dribble, hesitancy, incontinence). CONCLUSIONS: At long-term followup
      after hypospadias surgery urinary flow rates were significantly lower compared to
      age matched controls but still fell within the normal range. In the hypospadias
      cohort there was no significant association with lower urinary tract symptoms and
      poor urinary flow. Detection of poor urinary flow may indicate incomplete bladder
      emptying. The presence of severe chordee preoperatively is a significant risk
      factor for poor urinary flow rates on long-term followup.
CI  - Copyright (c) 2012 American Urological Association Education and Research, Inc.
      Published by Elsevier Inc. All rights reserved.
FAU - Perera, Marlon
AU  - Perera M
AD  - Douglas Stephens Surgical Research Unit, Murdoch Childrens Research Institute,
      Melbourne, Australia.
FAU - Jones, Brendan
AU  - Jones B
FAU - O'Brien, Mike
AU  - O'Brien M
FAU - Hutson, John M
AU  - Hutson JM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120817
PL  - United States
TA  - J Urol
JT  - The Journal of urology
JID - 0376374
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Humans
MH  - Hypospadias/*surgery
MH  - Male
MH  - Rheology
MH  - Urethra/*physiology
MH  - Urodynamics
EDAT- 2012/08/22 06:00
MHDA- 2013/01/01 06:00
CRDT- 2012/08/22 06:00
PHST- 2011/11/24 00:00 [received]
PHST- 2012/08/22 06:00 [entrez]
PHST- 2012/08/22 06:00 [pubmed]
PHST- 2013/01/01 06:00 [medline]
AID - S0022-5347(12)03662-2 [pii]
AID - 10.1016/j.juro.2012.04.105 [doi]
PST - ppublish
SO  - J Urol. 2012 Oct;188(4 Suppl):1457-62. doi: 10.1016/j.juro.2012.04.105. Epub 2012
      Aug 17.


PMID- 22906642
OWN - NLM
STAT- MEDLINE
DCOM- 20121231
LR  - 20181201
IS  - 1527-3792 (Electronic)
IS  - 0022-5347 (Linking)
VI  - 188
IP  - 4 Suppl
DP  - 2012 Oct
TI  - Regression of the mammary branch of the genitofemoral nerve may be necessary for 
      testicular descent in rats.
PG  - 1443-8
LID - 10.1016/j.juro.2012.02.041 [doi]
AB  - PURPOSE: Inguinoscrotal testicular descent has been proposed to occur via sensory
      fibers of the sexually dimorphic genitofemoral nerve, which release a
      neurotransmitter, calcitonin gene related peptide, to guide the migrating
      gubernaculum into the scrotum. We hypothesize that androgen mediated regression
      of the genitofemoral nerve mammary branch is necessary for inguinoscrotal descent
      in rats. We compared the spatiotemporal development of the genitofemoral nerve in
      control and antiandrogen treated rats. MATERIALS AND METHODS: A total of 29
      Sprague-Dawley(R) rats were collected (animal ethics committee approval A644) in 
      control and antiandrogen treated groups (flutamide, embryonic days 16 to 19, 75
      mg/kg body weight/5% ethanol + oil) on embryonic days 17 and 19, and on postnatal
      day 2. Sagittal sections of the gubernaculum and its surrounding structures were 
      processed for standard histology and immunohistochemistry for androgen receptor, 
      nerves (Tuj1), calcitonin gene related peptide (marker for genitofemoral nerve)
      and cell nuclei (DAPI). RESULTS: The inguinal mammary bud, its adjacent androgen 
      receptor and genitofemoral nerve mammary branch (containing calcitonin gene
      related peptide) persisted from embryonic day 17 to postnatal day 2 in all
      antiandrogen treated males, yet regressed in all control males by postnatal day
      2. CONCLUSIONS: Antiandrogens resulted in the persistence of the mammary branch
      and inguinal mammary bud. Persistent genitofemoral nerve mammary branches may
      arrest or slow down gubernacular migration by releasing calcitonin gene related
      peptide in the mammary inguinal fat pad, thus reducing the chemotactic gradient
      to calcitonin gene related peptide from genitofemoral nerve branches in the
      distal scrotum. We hypothesize that this process may be related to antiandrogen
      induced cryptorchidism in the rodent.
CI  - Copyright (c) 2012 American Urological Association Education and Research, Inc.
      Published by Elsevier Inc. All rights reserved.
FAU - Su, Shu
AU  - Su S
AD  - Department of Pediatrics, University of Melbourne, Parkville, Victoria,
      Australia.
FAU - Farmer, Pamela J
AU  - Farmer PJ
FAU - Li, Ruili
AU  - Li R
FAU - Sourial, Magdy
AU  - Sourial M
FAU - Buraundi, Silverton
AU  - Buraundi S
FAU - Bodemer, Daniela
AU  - Bodemer D
FAU - Southwell, Bridget R
AU  - Southwell BR
FAU - Hutson, John M
AU  - Hutson JM
LA  - eng
PT  - Journal Article
DEP - 20120817
PL  - United States
TA  - J Urol
JT  - The Journal of urology
JID - 0376374
RN  - JHB2QIZ69Z (Calcitonin Gene-Related Peptide)
SB  - IM
CIN - J Urol. 2012 Oct;188(4 Suppl):1449; discussion 1449. PMID: 22906673
MH  - Animals
MH  - Calcitonin Gene-Related Peptide/*physiology
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Testis/*embryology/*innervation
EDAT- 2012/08/22 06:00
MHDA- 2013/01/01 06:00
CRDT- 2012/08/22 06:00
PHST- 2011/11/27 00:00 [received]
PHST- 2012/08/22 06:00 [entrez]
PHST- 2012/08/22 06:00 [pubmed]
PHST- 2013/01/01 06:00 [medline]
AID - S0022-5347(12)00400-4 [pii]
AID - 10.1016/j.juro.2012.02.041 [doi]
PST - ppublish
SO  - J Urol. 2012 Oct;188(4 Suppl):1443-8. doi: 10.1016/j.juro.2012.02.041. Epub 2012 
      Aug 17.


PMID- 22906301
OWN - NLM
STAT- MEDLINE
DCOM- 20130114
LR  - 20211021
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 13
DP  - 2012 Aug 21
TI  - Assessing the quality of informed consent in a resource-limited setting: a
      cross-sectional study.
PG  - 21
LID - 10.1186/1472-6939-13-21 [doi]
AB  - BACKGROUND: The process of obtaining informed consent continues to be a
      contentious issue in clinical and public health research carried out in
      resource-limited settings. We sought to evaluate this process among human
      research participants in randomly selected active research studies approved by
      the School of Medicine Research and Ethics Committee at the College of Health
      Sciences, Makerere University. METHODS: Data were collected using semi-structured
      interviewer-administered questionnaires on clinic days after initial or repeat
      informed consent procedures for the respective clinical studies had been
      administered to each study participant. RESULTS: Of the 600 participants
      interviewed, two thirds (64.2%, 385/600) were female. Overall mean age of study
      participants was 37.6 (SD = 7.7) years. Amongst all participants, less than a
      tenth (5.9%, 35/598) reported that they were not given enough information before 
      making a decision to participate. A similar proportion (5.7%, 34/597) reported
      that they had not signed a consent form prior to making a decision to participate
      in the study. A third (33.7%, 201/596) of the participants were not aware that
      they could, at any time, voluntarily withdraw participation from these studies.
      Participants in clinical trials were 50% less likely than those in observational 
      studies [clinical trial vs. observational; (odds ratio, OR = 0.5; 95% CI:
      0.35-0.78)] to perceive that refusal to participate in the parent research
      project would affect their regular medical care. CONCLUSIONS: Most of the
      participants signed informed consent forms and a vast majority felt that they
      received enough information before deciding to participate. On the contrary,
      several were not aware that they could voluntarily withdraw their participation. 
      Participants in observational studies were more likely than those in clinical
      trials to perceive that refusal to participate in the parent study would affect
      their regular medical care.
FAU - Kiguba, Ronald
AU  - Kiguba R
AD  - Makerere University College of Health Sciences, Kampala, Uganda.
      kiguba@googlemail.com
FAU - Kutyabami, Paul
AU  - Kutyabami P
FAU - Kiwuwa, Stephen
AU  - Kiwuwa S
FAU - Katabira, Elly
AU  - Katabira E
FAU - Sewankambo, Nelson K
AU  - Sewankambo NK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120821
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Adult
MH  - Awareness
MH  - Clinical Trials as Topic/*ethics
MH  - Comprehension
MH  - Cross-Sectional Studies
MH  - Female
MH  - Health Resources/*supply & distribution
MH  - *Health Services Accessibility
MH  - Humans
MH  - Informed Consent/ethics/*standards
MH  - Male
MH  - Middle Aged
MH  - Research Design
MH  - Research Subjects
MH  - Surveys and Questionnaires
MH  - Uganda
PMC - PMC3478970
EDAT- 2012/08/22 06:00
MHDA- 2013/01/15 06:00
CRDT- 2012/08/22 06:00
PHST- 2011/04/09 00:00 [received]
PHST- 2012/08/13 00:00 [accepted]
PHST- 2012/08/22 06:00 [entrez]
PHST- 2012/08/22 06:00 [pubmed]
PHST- 2013/01/15 06:00 [medline]
AID - 1472-6939-13-21 [pii]
AID - 10.1186/1472-6939-13-21 [doi]
PST - epublish
SO  - BMC Med Ethics. 2012 Aug 21;13:21. doi: 10.1186/1472-6939-13-21.


PMID- 22906192
OWN - NLM
STAT- MEDLINE
DCOM- 20130422
LR  - 20181202
IS  - 1557-7708 (Electronic)
IS  - 1075-5535 (Linking)
VI  - 18
IP  - 11
DP  - 2012 Nov
TI  - Complementary and alternative medicine use in radiotherapy: what are patients
      using?
PG  - 1014-20
LID - 10.1089/acm.2011.0334 [doi]
AB  - OBJECTIVES: Complementary and alternative medicine (CAM) use by patients could
      interact in unpredictable ways with conventional therapies. This trial was
      designed to study the prevalence, types, and clinical implications of CAM use in 
      patients with cancer who are receiving radiotherapy. DESIGN: A validated
      questionnaire was given to consenting outpatients in this ethics-approved study. 
      Questions specified types of CAM used, clinician knowledge, reason for use,
      perceived effectiveness, safety, and cost. RESULTS: Of the 101 assessable
      questionnaires, 38 patients (38%) of the total patient group used CAM, with
      vitamins (53%), antioxidants (29%), spiritual/meditation practices (29%), and
      herbs (18%) being the most commonly used. The intention of CAM use was to improve
      quality of life in 69% of patients and for either hope of cure or to assist other
      forms of treatment in 26%. The majority of patients (58%) were using CAM prior to
      their diagnosis of cancer, with 40% starting at diagnosis or during conventional 
      treatment. Patients spent up to $300/month on CAM use. Patients using CAM were
      significantly more likely to also receive chemotherapy versus non-CAM users (45% 
      versus 24%, p=0.045). Significantly fewer CAM users expected cure from
      conventional therapy, compared to non-CAM users (50% versus 75%, p=0.016). More
      CAM users expected conventional therapy to prolong life (58% versus 32%,
      p<0.001). Only 40% discussed CAM use with their oncologists. CONCLUSIONS: CAM is 
      commonly used by patients with cancer. CAMs, particularly antioxidants, are being
      taken which could negate the underlying free-radical tumorcidal effects of
      radiotherapy. Oncologists need to have greater awareness of this use and of its
      potential adverse consequences.
FAU - Gillett, John
AU  - Gillett J
AD  - Radiation Oncology Queensland, St. Andrews Cancer Care Center, Toowoomba,
      Queensland, Australia. John_Gillett@health.qld.gov.au
FAU - Ientile, Clare
AU  - Ientile C
FAU - Hiscock, Joanne
AU  - Hiscock J
FAU - Plank, Ashley
AU  - Plank A
FAU - Martin, Jarad M
AU  - Martin JM
LA  - eng
PT  - Journal Article
DEP - 20120820
PL  - United States
TA  - J Altern Complement Med
JT  - Journal of alternative and complementary medicine (New York, N.Y.)
JID - 9508124
RN  - 0 (Antioxidants)
RN  - 0 (Plant Extracts)
RN  - 0 (Vitamins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antioxidants/*therapeutic use
MH  - Attitude to Health
MH  - Complementary Therapies/economics/methods/*statistics & numerical data
MH  - Female
MH  - Humans
MH  - Intention
MH  - Male
MH  - Meditation
MH  - Middle Aged
MH  - *Motivation
MH  - Neoplasms/drug therapy/radiotherapy/*therapy
MH  - *Patient Acceptance of Health Care
MH  - Physician-Patient Relations
MH  - Phytotherapy
MH  - Plant Extracts/therapeutic use
MH  - Quality of Life
MH  - Spirituality
MH  - Surveys and Questionnaires
MH  - Vitamins/therapeutic use
MH  - Young Adult
EDAT- 2012/08/22 06:00
MHDA- 2013/04/23 06:00
CRDT- 2012/08/22 06:00
PHST- 2012/08/22 06:00 [entrez]
PHST- 2012/08/22 06:00 [pubmed]
PHST- 2013/04/23 06:00 [medline]
AID - 10.1089/acm.2011.0334 [doi]
PST - ppublish
SO  - J Altern Complement Med. 2012 Nov;18(11):1014-20. doi: 10.1089/acm.2011.0334.
      Epub 2012 Aug 20.


PMID- 22906076
OWN - NLM
STAT- MEDLINE
DCOM- 20130124
LR  - 20120920
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 60
IP  - 37
DP  - 2012 Sep 19
TI  - Effects of preslaughter stress levels on the post-mortem sarcoplasmic proteomic
      profile of gilthead seabream muscle.
PG  - 9443-53
AB  - Fish welfare is an important concern in aquaculture, not only due to the ethical 
      implications but also for productivity and quality-related reasons. The purpose
      of this study was to track soluble proteome expression in post-mortem gilthead
      seabream muscle and to observe how preslaughter stress affects these post-mortem 
      processes. For the experiment, two groups of gilthead seabream (n = 5) were
      subjected to distinct levels of preslaughter stress, with three muscle samples
      being taken from each fish. Proteins were extracted from the muscle samples,
      fractionated, and separated by 2DE. Protein identification was performed by
      MALDI-TOF-TOF MS. Analysis of the results indicates changes on several cellular
      pathways, with some of these changes being attributable to oxidative and
      proteolytic activity on sarcoplasmic proteins, together with leaking of
      myofibrillar proteins. These processes appear to have been hastened by
      preslaughter stress, confirming that it induces clear post-mortem changes in the 
      muscle proteome of gilthead seabream.
FAU - Silva, Tome S
AU  - Silva TS
AD  - CIMAR/CCMAR, Centre of Marine Sciences of Algarve, University of Algarve, Faro,
      Portugal. tome@tomesilva.com
FAU - Cordeiro, Odete D
AU  - Cordeiro OD
FAU - Matos, Elisabete D
AU  - Matos ED
FAU - Wulff, Tune
AU  - Wulff T
FAU - Dias, Jorge P
AU  - Dias JP
FAU - Jessen, Flemming
AU  - Jessen F
FAU - Rodrigues, Pedro M
AU  - Rodrigues PM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120910
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Muscle Proteins)
SB  - IM
MH  - Animals
MH  - Aquaculture/*methods
MH  - Electrophoresis, Gel, Two-Dimensional/veterinary
MH  - Food Quality
MH  - Muscle Proteins/*analysis
MH  - Muscles/*chemistry
MH  - Oxidative Stress
MH  - *Postmortem Changes
MH  - Proteolysis
MH  - Proteomics
MH  - Sarcoplasmic Reticulum/*chemistry
MH  - Sea Bream/*metabolism
MH  - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/veterinary
MH  - Stress, Psychological/metabolism
EDAT- 2012/08/22 06:00
MHDA- 2013/01/25 06:00
CRDT- 2012/08/22 06:00
PHST- 2012/08/22 06:00 [entrez]
PHST- 2012/08/22 06:00 [pubmed]
PHST- 2013/01/25 06:00 [medline]
AID - 10.1021/jf301766e [doi]
PST - ppublish
SO  - J Agric Food Chem. 2012 Sep 19;60(37):9443-53. doi: 10.1021/jf301766e. Epub 2012 
      Sep 10.


PMID- 22905999
OWN - NLM
STAT- MEDLINE
DCOM- 20140113
LR  - 20181202
IS  - 1365-2702 (Electronic)
IS  - 0962-1067 (Linking)
VI  - 22
IP  - 13-14
DP  - 2013 Jul
TI  - Teaching spiritual care--a grounded theory study among undergraduate nursing
      educators.
PG  - 1951-60
LID - 10.1111/j.1365-2702.2012.04203.x [doi]
AB  - AIMS AND OBJECTIVES: To explore teachers' understanding of spirituality and how
      they prepare undergraduate nursing students to recognise spiritual cues and learn
      to assess and provide spiritual care. BACKGROUND: Nursing education addresses
      patient care in all domains of the person. Systematic teaching and supervision of
      students to prepare them to assist patients spiritually is an important part of
      holistic care. However, few role models for spiritual care are seen in clinical
      practice, and limited research addresses necessary student competencies or how
      teachers can best facilitate this process. DESIGN: Grounded theory was used to
      identify teachers' main concern and develop a substantive grounded theory.
      METHODS: Data collected during semi-structured interviews at three Norwegian
      University Colleges in five focus groups with 19 undergraduate nursing teachers
      were conducted from 2008 to 2009. Data were analysed through constant comparison 
      of transcribed interviews until categories emerged and were saturated. RESULTS:
      The participants' main concern was 'How to help students recognize cues and ways 
      of providing spiritual care'. Participants resolved this by 'Journeying with
      Students through their Maturation'. This basic social process has three iterative
      phases that develop throughout the nursing programme: 'Raising Student awareness 
      to Recognize the Essence of Spirituality', 'Assisting Students to Overcome
      Personal Barriers', and 'Mentoring Students' Competency in Spiritual Care'.
      CONCLUSION: Nursing education should prepare students to recognise and act on
      spiritual cues. Making spiritual assessment and interventions more visible and
      explicit throughout nursing programmes, in both classroom and clinical settings, 
      will facilitate student maturation as they learn to integrate theoretical
      thinking into clinical practice. RELEVANCE TO CLINICAL PRACTICE: Nursing students
      need role models who demonstrate spiritual care in the fast-paced hospital
      environment as well as in other clinical practice settings. To model spirituality
      as part of nursing care can assist students to overcome their vulnerability and
      to safeguard ethical issues and promote patient integrity.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Cone, Pamela H
AU  - Cone PH
AD  - Azusa Pacific University, Azusa, CA 91702, USA. pcone@apu.edu
FAU - Giske, Tove
AU  - Giske T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120821
PL  - England
TA  - J Clin Nurs
JT  - Journal of clinical nursing
JID - 9207302
CIN - J Clin Nurs. 2014 Sep;23(17-18):2694. PMID: 25047388
MH  - Adult
MH  - Awareness
MH  - *Education, Nursing
MH  - *Faculty, Nursing
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Models, Theoretical
MH  - Norway
MH  - *Spirituality
MH  - Workforce
EDAT- 2012/08/22 06:00
MHDA- 2014/01/15 06:00
CRDT- 2012/08/22 06:00
PHST- 2012/08/22 06:00 [entrez]
PHST- 2012/08/22 06:00 [pubmed]
PHST- 2014/01/15 06:00 [medline]
AID - 10.1111/j.1365-2702.2012.04203.x [doi]
PST - ppublish
SO  - J Clin Nurs. 2013 Jul;22(13-14):1951-60. doi: 10.1111/j.1365-2702.2012.04203.x.
      Epub 2012 Aug 21.


PMID- 22905605
OWN - NLM
STAT- MEDLINE
DCOM- 20120925
LR  - 20120821
IS  - 1096-9012 (Print)
IS  - 1096-9012 (Linking)
VI  - 57
IP  - 4
DP  - 2012 Jul-Aug
TI  - The clinical ethics consultant: verifying the qualifications of a new type of
      practitioner in a community hospital.
PG  - 264-73; discussion 274-5
AB  - Ethics consultation has been occurring in various forms within hospitals for more
      than 30 years. These consultations constitute a clinical act, and as such, the
      qualifications of those who provide them must be verified by the hospitals at
      which the ethics consultants practice. The clinical nature of the practice
      exposes the participants to malpractice liability. The field of medical ethics
      has struggled to provide a clear set of knowledge and skills that characterize
      its practitioners. Hospitals are faced with the immediate task of assessing the
      qualifications of and ensuring malpractice coverage for individuals providing
      clinical ethics consultation. We offer one example of how a community hospital
      has addressed this challenge.
FAU - Andereck, William S
AU  - Andereck WS
AD  - California Pacific Medical Center, Program in Medicine & Human Values, San
      Francisco, USA.
FAU - McGaughey, J Westly
AU  - McGaughey JW
FAU - Jonsen, Albert R
AU  - Jonsen AR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Healthc Manag
JT  - Journal of healthcare management / American College of Healthcare Executives
JID - 9803529
MH  - *Ethicists
MH  - *Hospitals, Community
MH  - *Professional Competence
MH  - United States
EDAT- 2012/08/22 06:00
MHDA- 2012/09/26 06:00
CRDT- 2012/08/22 06:00
PHST- 2012/08/22 06:00 [entrez]
PHST- 2012/08/22 06:00 [pubmed]
PHST- 2012/09/26 06:00 [medline]
PST - ppublish
SO  - J Healthc Manag. 2012 Jul-Aug;57(4):264-73; discussion 274-5.


PMID- 22905323
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2152-7806 (Electronic)
IS  - 2152-7806 (Linking)
VI  - 3
IP  - Suppl 3
DP  - 2012
TI  - Consequences and potential problems of operating room outbursts and temper
      tantrums by surgeons.
PG  - S167-73
LID - 10.4103/2152-7806.98577 [doi]
AB  - BACKGROUND: Anecdotal tales of colorful temper tantrums and outbursts by surgeons
      directed at operating room nurses and at times other health care providers, like 
      residents and fellows, are part of the history of surgery and include not only
      verbal abuse but also instrument throwing and real harassment. Our
      Editor-in-Chief, Dr. Nancy Epstein, has made the literature review of "Are there 
      truly any risks and consequences when spine surgeons mistreat their predominantly
      female OR nursing staff/colleagues, and what can we do about it?," an assigned
      topic for members of the editorial board as part of a new category entitled
      Ethical Note for our journal. This is a topic long overdue and I chose to
      research it. METHODS: There is no medical literature to review dealing with nurse
      abuse. To research this topic, one has to involve business, industry, educational
      institutions, compliance standards and practices, and existing state and federal 
      laws. I asked Dr. Rosanne Wille to co-author this paper since, as the former Dean
      of Nursing and then Provost and Senior Vice President for Academic Affairs at a
      major higher educational institution, she had personal experience with compliance
      regulations and both sexual harassment and employment discrimination complaints, 
      to make this review meaningful. RESULTS: A review of the existing business
      practices and both state and federal laws strongly suggests that although there
      has not been any specific legal complaint that is part of the public record, any 
      surgeon who chooses to act out his or her frustration and nervous energy demands 
      by abusing co-workers on the health care team, and in this case specifically
      operating room personnel, is taking a chance of making legal history with
      financial outcomes which only an actual trial can predict or determine. Even more
      serious outcomes of an out-of-control temper tantrum and disruptive behavior can 
      terminate, after multiple hearings and appeals, in adverse decisions affecting
      hospital privileges. CONCLUSIONS: Surgeons who abuse other health care workers
      are in violation of institutional bylaws and compliance regulations and create a 
      hostile environment at work which adversely affects efficient productivity and
      violates specific State and Federal laws which prohibit discrimination based on
      race, color, sex, religion, or national origin.
FAU - Jacobs, George B
AU  - Jacobs GB
AD  - Chairman and Professor Emeritus, Department of Neurosurgery, Hackensack
      University Medical Center, University of Medicine and Dentistry of New Jersey
      (New Jersey Medical School), Hackinsack and Newark NJ 07601, USA.
FAU - Wille, Rosanne L
AU  - Wille RL
LA  - eng
PT  - Journal Article
DEP - 20120717
PL  - United States
TA  - Surg Neurol Int
JT  - Surgical neurology international
JID - 101535836
PMC - PMC3422097
OTO - NOTNLM
OT  - Compliance
OT  - discrimination
OT  - employment
OT  - federal laws
OT  - harassment
OT  - hospital privileges
OT  - hostile
OT  - sexual
OT  - state laws
EDAT- 2012/08/21 06:00
MHDA- 2012/08/21 06:01
CRDT- 2012/08/21 06:00
PHST- 2012/03/02 00:00 [received]
PHST- 2012/05/08 00:00 [accepted]
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2012/08/21 06:01 [medline]
AID - 10.4103/2152-7806.98577 [doi]
AID - SNI-3-167 [pii]
PST - ppublish
SO  - Surg Neurol Int. 2012;3(Suppl 3):S167-73. doi: 10.4103/2152-7806.98577. Epub 2012
      Jul 17.


PMID- 22904668
OWN - NLM
STAT- MEDLINE
DCOM- 20121128
LR  - 20220317
IS  - 1449-2288 (Electronic)
IS  - 1449-2288 (Linking)
VI  - 8
IP  - 7
DP  - 2012
TI  - Preservation of fertility in females treated for cancer.
PG  - 1005-12
LID - 10.7150/ijbs.4800 [doi]
AB  - Advancements of diagnosis and treatment have substantially improved cancer
      survival rates in the last few decades. The increasing number of survivors
      focuses attention on long-term effects caused by cancer treatment and its impact 
      on quality of life. Ovarian failure is one of the major sequelae of cytotoxic
      chemotherapy and/or radiotherapy in female children and reproductive-age women.
      Oncologists should address the patients about fertility preservation options
      before therapy. Embryo cryopreservation is the only well-established method for
      females in preserving fertility; however other strategies including ovarian
      suppression, ovarian transposition and cryopreservation of oocytes and ovarian
      tissue are still experimental. Patients need advice and to know which are the
      most practical options for them. This article reviews the available fertility
      preservation methods in women, and the related issues including normal physiology
      of the ovary, effect of anticancer therapy on fertility, role of the oncologist
      and ethics. We performed a MEDLINE search from 1971 to 2011 in a similar way as
      Jensen et al. 2011, using the following MeSH terms: antineoplastic agents;
      ovarian failure; premature; infertility, female; fertility preservation; child
      and cancer; reproductive technologies, assisted.
FAU - Chuai, Yunhai
AU  - Chuai Y
AD  - Department of Obstetrics and Gynecology, Navy General Hospital, Beijing, China.
FAU - Xu, Xiaobin
AU  - Xu X
FAU - Wang, Aiming
AU  - Wang A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120801
PL  - Australia
TA  - Int J Biol Sci
JT  - International journal of biological sciences
JID - 101235568
SB  - IM
MH  - Cryopreservation/methods
MH  - Female
MH  - Fertility Preservation/*methods
MH  - Humans
MH  - *Infertility, Female
MH  - Neoplasms/*drug therapy/*radiotherapy
MH  - Ovary/drug effects/radiation effects
PMC - PMC3421231
OTO - NOTNLM
OT  - Cancer patient
OT  - Females
OT  - Fertility Preservation
EDAT- 2012/08/21 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/08/21 06:00
PHST- 2012/07/01 00:00 [received]
PHST- 2012/07/29 00:00 [accepted]
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.7150/ijbs.4800 [doi]
AID - ijbsv08p1005 [pii]
PST - ppublish
SO  - Int J Biol Sci. 2012;8(7):1005-12. doi: 10.7150/ijbs.4800. Epub 2012 Aug 1.


PMID- 22904658
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1305-7464 (Electronic)
VI  - 6
IP  - 3
DP  - 2012 Jul
TI  - Global oral health course: Perception among dental students in central India.
PG  - 295-301
AB  - A questionnaire study was conducted among dental students in Central India. The
      study population included 264 dental students, who voluntarily completed a
      questionnaire, comprising of 16 close ended questions. There were 9 questions to 
      judge knowledge and 5 questions for attitude assessment towards global oral
      health course. Two additional questions were included to assess the willingness
      to volunteer in international setting; and also, to assess dental student's
      perspection on global oral health course. Chi Square test was used to compare
      between categorical variables. Analysis of Variance (ANOVA) was used to compare
      mean of knowledge and attitude scores. P value of .05 was considered significant 
      for all statistical analysis. Eighty seven percent of the surveyed students (222)
      stated that they would consider volunteering their dental skills as a future
      dentist in international setting. Majority of the students in the present study
      were not aware about the global oral health status (99.2%) and theoral health
      care systems of industrialized and emerging economies (99.2%), had not been
      trained to serve underserved population (68%), had not been trained in global
      health ethics (70.1%) and none of the students had been trained for cultural
      competence in addressing international oral health issues (100%). Most of the
      dental students were not aware, that, WHO created basic package of oral care
      (63%) about the primary health care strategy (59.5%) and about the role and
      functions of FDI (66.7%). The majority of students expressed a desire to
      volunteer their professional services in international settings. However few
      students knew about WHO's BPOC or FDI'S role in global oral health. The findings 
      indicate a need for global oral health course among dental students in Central
      India.
FAU - Singh, Abhinav
AU  - Singh A
AD  - Department of Public Health Dentistry, ESIC Dental College & Hospital, Rohini -
      New Delhi, Under Ministry of Labour & Employment - Government of INDIA.
FAU - Purohit, Bharathi
AU  - Purohit B
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Eur J Dent
JT  - European journal of dentistry
JID - 101303672
PMC - PMC3420837
OTO - NOTNLM
OT  - Global oral health
OT  - dental volunteer
OT  - pre doctoral dental education
OT  - primary oral health
EDAT- 2012/08/21 06:00
MHDA- 2012/08/21 06:01
CRDT- 2012/08/21 06:00
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2012/08/21 06:01 [medline]
PST - ppublish
SO  - Eur J Dent. 2012 Jul;6(3):295-301.


PMID- 22904647
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1179-1373 (Electronic)
IS  - 1179-1373 (Linking)
VI  - 4
DP  - 2012
TI  - Predictors of refusal of provider initiated HIV testing among clients visiting
      adult outpatient departments in Jimma town, Oromia Region, Ethiopia: unmatched
      case control study.
PG  - 103-15
LID - 10.2147/HIV.S33122 [doi]
AB  - BACKGROUND: Currently, provider-initiated human immunodeficiency virus (HIV)
      testing (PIHT) in health facilities is one of the strategies to advance HIV
      testing and related services. However, many HIV infected clients are missing the 
      opportunities. This study intends to identify predictors of refusal of PIHT among
      clients visiting adult outpatient departments (OPDs) in Jimma town. METHODS: An
      unmatched case control study was conducted among 296 clients: 149 cases refusing 
      HIV testing and 147 controls accepting HIV testing. The study recruited clients
      from OPDs of four public health facilities between March 6 and April 8, 2011
      using consecutive sampling. The study instrument was adapted mainly considering
      health belief model (HBM). Jimma University ethical committee reviewed the study 
      protocol. Data were collected by face-to-face interview and analyzed using SPSS
      Statistics (IBM Corporation, Somers, NY) software, version 16.0. Data were
      subjected to factor and reliability analysis. For prediction analysis, the study 
      used logistic regression and odds ratio (OR) with 95% confidence interval (CI).
      To see the effects among HBM constructs, the study used standardized beta (beta) 
      coefficients at P < 0.05. RESULTS: The study findings showed adjusted protective 
      effects on refusal of PIHT for residence outside study town [adjusted OR (AOR)
      (95% CI) = 0.41 (0.22-0.79)] and higher scores of perceived benefit of early
      testing [AOR (95% CI)] = 0.86 (0.69-0.99)], self efficacy to live with HIV [AOR
      (95% CI) = 0.79 (0.66-0.93)], nondisclosure agreement [AOR (95% CI) = 0.74
      (0.58-0.93)], perceived explicitness of opt-out right during initiation [AOR (95%
      CI) = 0.74 (0.56-0.98)] and clients' perceptions of selective initiation of HIV
      suspected [AOR (95% CI) = 0.54 (0.41-0.73)]. On the other hand, report of recent 
      testing [AOR (95% CI) = 3.82 (1.71-8.55)] and perceived unpreparedness for
      testing [AOR (95% CI) = 1.86 (1.57-2.21)] aggravated refusal of PIHT. Exposure to
      cues to testing significantly reduced perceived barriers [beta (P) = -0.05
      (0.037)]. CONCLUSION: Clients' perceived barriers: feeling of unpreparedness for 
      testing strongly aggravated refusal of test. Enhanced self-efficacy to live with 
      HIV and presence of cues to HIV testing would reduce unpreparedness and protect
      from refusing PIHT.
FAU - Lemu, Yohannes Kebede
AU  - Lemu YK
AD  - Department of Health Education and Behavioral Sciences, Jimma University, Jimma, 
      Ethiopia.
FAU - Koricha, Zewdie Birhanu
AU  - Koricha ZB
FAU - Gebretsadik, Lakew Abebe
AU  - Gebretsadik LA
FAU - Roro, Ameyu Godesso
AU  - Roro AG
LA  - eng
PT  - Journal Article
DEP - 20120802
PL  - New Zealand
TA  - HIV AIDS (Auckl)
JT  - HIV/AIDS (Auckland, N.Z.)
JID - 101515943
PMC - PMC3418077
OTO - NOTNLM
OT  - HIV testing
OT  - acceptance
OT  - provider-initiated
EDAT- 2012/08/21 06:00
MHDA- 2012/08/21 06:01
CRDT- 2012/08/21 06:00
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2012/08/21 06:01 [medline]
AID - 10.2147/HIV.S33122 [doi]
AID - hiv-4-103 [pii]
PST - ppublish
SO  - HIV AIDS (Auckl). 2012;4:103-15. doi: 10.2147/HIV.S33122. Epub 2012 Aug 2.


PMID- 22904609
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1176-7529 (Print)
IS  - 1176-7529 (Linking)
VI  - 9
IP  - 3
DP  - 2012 Sep
TI  - Prenatal Dexamethasone for Congenital Adrenal Hyperplasia: An Ethics Canary in
      the Modern Medical Mine.
PG  - 277-294
AB  - Following extensive examination of published and unpublished materials, we
      provide a history of the use of dexamethasone in pregnant women at risk of
      carrying a female fetus affected by congenital adrenal hyperplasia (CAH). This
      intervention has been aimed at preventing development of ambiguous genitalia, the
      urogenital sinus, tomboyism, and lesbianism. We map out ethical problems in this 
      history, including: misleading promotion to physicians and CAH-affected families;
      de facto experimentation without the necessary protections of approved research; 
      troubling parallels to the history of prenatal use of diethylstilbestrol (DES);
      and the use of medicine and public monies to attempt prevention of benign
      behavioral sex variations. Critical attention is directed at recent
      investigations by the U.S. Food and Drug Administration (FDA) and Office of Human
      Research Protections (OHRP); we argue that the weak and unsupported conclusions
      of these investigations indicate major gaps in the systems meant to protect
      subjects of high-risk medical research.
FAU - Dreger, Alice
AU  - Dreger A
FAU - Feder, Ellen K
AU  - Feder EK
FAU - Tamar-Mattis, Anne
AU  - Tamar-Mattis A
LA  - eng
PT  - Journal Article
DEP - 20120731
PL  - Netherlands
TA  - J Bioeth Inq
JT  - Journal of bioethical inquiry
JID - 101250741
PMC - PMC3416978
EDAT- 2012/08/21 06:00
MHDA- 2012/08/21 06:01
CRDT- 2012/08/21 06:00
PHST- 2012/04/11 00:00 [received]
PHST- 2012/05/14 00:00 [accepted]
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2012/08/21 06:01 [medline]
AID - 10.1007/s11673-012-9384-9 [doi]
AID - 9384 [pii]
PST - ppublish
SO  - J Bioeth Inq. 2012 Sep;9(3):277-294. doi: 10.1007/s11673-012-9384-9. Epub 2012
      Jul 31.


PMID- 22904233
OWN - NLM
STAT- MEDLINE
DCOM- 20130122
LR  - 20181201
IS  - 1469-0756 (Electronic)
IS  - 0032-5473 (Linking)
VI  - 88
IP  - 1043
DP  - 2012 Sep
TI  - Ethical and practical considerations in prescribing animal-derived medication.
PG  - 497-8
LID - 10.1136/postgradmedj-2012-131053 [doi]
FAU - Corfield, Lorraine
AU  - Corfield L
FAU - Granne, Ingrid
AU  - Granne I
LA  - eng
PT  - Editorial
PT  - Comment
PL  - England
TA  - Postgrad Med J
JT  - Postgraduate medical journal
JID - 0234135
RN  - 0 (Excipients)
RN  - 9000-70-8 (Gelatin)
SB  - IM
CON - Postgrad Med J. 2012 Sep;88(1043):499-502. PMID: 22375036
MH  - Animals
MH  - *Diet
MH  - Excipients/*administration & dosage
MH  - Female
MH  - Gelatin/*administration & dosage
MH  - Humans
MH  - Male
MH  - *Religion and Medicine
EDAT- 2012/08/21 06:00
MHDA- 2013/01/23 06:00
CRDT- 2012/08/21 06:00
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2013/01/23 06:00 [medline]
AID - postgradmedj-2012-131053 [pii]
AID - 10.1136/postgradmedj-2012-131053 [doi]
PST - ppublish
SO  - Postgrad Med J. 2012 Sep;88(1043):497-8. doi: 10.1136/postgradmedj-2012-131053.


PMID- 22903777
OWN - NLM
STAT- MEDLINE
DCOM- 20130219
LR  - 20220409
IS  - 1552-4833 (Electronic)
IS  - 1552-4825 (Linking)
VI  - 158A
IP  - 10
DP  - 2012 Oct
TI  - "I want to know what's in Pandora's Box": comparing stakeholder perspectives on
      incidental findings in clinical whole genomic sequencing.
PG  - 2519-25
LID - 10.1002/ajmg.a.35554 [doi]
AB  - Whole genomic sequencing (WGS) promises significant personalized health benefits,
      and its increasingly low cost makes wide clinical use inevitable. However, a core
      challenge is "incidental findings" (IF). Using focus groups, we explored
      attitudes about the disclosure of IF in clinical settings from three
      perspectives: Genetics health-care professionals, the general public, and parents
      whose children have experienced genetic testing. Analysis was based on a
      framework approach. All three groups considered practical and ethical
      considerations. There was consensus that IF presented challenges for disclosure
      and a pre-test patient-clinician discussion was vital for clarification and
      agreement. The professionals favored targeted analysis to limit data handling and
      focus pre-test discussions on medical relevance. Their perspective highlighted
      ethical concepts of justice and beneficence. The lay groups' standpoint
      emphasized autonomy and patients' rights to choose what findings they receive,
      and that patients accept the consequences of any potential anxiety and
      uncertainty. The lay groups also felt that it was their responsibility to check
      genomic developments over time with their original test results and saw patient
      responsibility as an important part of patient choice.
CI  - Copyright (c) 2012 Wiley Periodicals, Inc.
FAU - Townsend, Anne
AU  - Townsend A
AD  - The W. Maurice Young Centre for Applied Ethics, University of British Columbia,
      Vancouver, Canada. atownsen@exchange.ubc.ca
FAU - Adam, Shelin
AU  - Adam S
FAU - Birch, Patricia H
AU  - Birch PH
FAU - Lohn, Zoe
AU  - Lohn Z
FAU - Rousseau, Francois
AU  - Rousseau F
FAU - Friedman, Jan M
AU  - Friedman JM
LA  - eng
PT  - Journal Article
DEP - 20120817
PL  - United States
TA  - Am J Med Genet A
JT  - American journal of medical genetics. Part A
JID - 101235741
SB  - IM
MH  - Attitude of Health Personnel
MH  - Attitude to Health
MH  - Decision Making
MH  - Disclosure
MH  - Focus Groups
MH  - *Genetic Testing
MH  - *Genomics
MH  - Humans
MH  - *Incidental Findings
MH  - Patient Rights
MH  - Patients/*psychology
EDAT- 2012/08/21 06:00
MHDA- 2013/02/21 06:00
CRDT- 2012/08/21 06:00
PHST- 2012/04/02 00:00 [received]
PHST- 2012/06/06 00:00 [accepted]
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2013/02/21 06:00 [medline]
AID - 10.1002/ajmg.a.35554 [doi]
PST - ppublish
SO  - Am J Med Genet A. 2012 Oct;158A(10):2519-25. doi: 10.1002/ajmg.a.35554. Epub 2012
      Aug 17.


PMID- 22903641
OWN - NLM
STAT- MEDLINE
DCOM- 20130807
LR  - 20211021
IS  - 1432-1084 (Electronic)
IS  - 0938-7994 (Linking)
VI  - 23
IP  - 3
DP  - 2013 Mar
TI  - Reliability and diagnostic accuracy of qualitative evaluation of
      diffusion-weighted MRI combined with conventional MRI in differentiating between 
      complete and partial anterior cruciate ligament tears.
PG  - 845-54
LID - 10.1007/s00330-012-2633-9 [doi]
AB  - OBJECTIVES: To assess the reliability and diagnostic accuracy of qualitative
      evaluation of apparent diffusion coefficient (ADC) mapping with magnetic
      resonance imaging (MRI) in differentiating between complete and partial anterior 
      cruciate ligament (ACL) tears. METHODS: This prospective study protocol was
      approved by the institutional ethics review board and informed consent was
      obtained from all the patients. Eighty-five patients (35 women and 50 men, mean
      age 34.1 years) with recent (<4 months) knee trauma with suspected ACL injury
      underwent conventional MRI (T1-weighted and T2-weighted sequences with fat
      saturation) associated with ADC mapping. MR images were read qualitatively
      without and then with ADC mapping by three radiologists, with analysis of direct 
      signs of a traumatic ACL tear and a second-reading. Dynamic X-rays (43 patients) 
      or arthroscopies (42 patients) were used as reference standards. RESULTS: For
      complete ACL tear diagnosis (67 patients), sensitivity and specificity were 87%
      and 50% respectively with conventional MRI, and 96% and 94% respectively with ADC
      mapping (P < 0.01 for specificity). Inter-observer correlations between
      musculoskeletal radiologists were almost perfect (kappa = 0.81) with ADC mapping 
      and fair with conventional MRI on the second-reading. CONCLUSIONS: ADC mapping
      associated with conventional MR sequences is a reproducible method to better
      differentiate complete and partial ACL tears.
FAU - Delin, Cyrille
AU  - Delin C
AD  - Reseau d'Imagerie Medicale Maussins-Nollet, 114 rue Nollet, 75017 Paris, France. 
      cdelin@maunol.fr
FAU - Silvera, Stephane
AU  - Silvera S
FAU - Coste, Joel
AU  - Coste J
FAU - Thelen, Philippe
AU  - Thelen P
FAU - Lefevre, Nicolas
AU  - Lefevre N
FAU - Ehkirch, Francois-Paul
AU  - Ehkirch FP
FAU - Le Couls, Vincent
AU  - Le Couls V
FAU - Oudjit, Ammar
AU  - Oudjit A
FAU - Radier, Catherine
AU  - Radier C
FAU - Legmann, Paul
AU  - Legmann P
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
DEP - 20120819
PL  - Germany
TA  - Eur Radiol
JT  - European radiology
JID - 9114774
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anterior Cruciate Ligament/*pathology
MH  - *Anterior Cruciate Ligament Injuries
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Knee Injuries/*pathology
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - *Trauma Severity Indices
MH  - Young Adult
EDAT- 2012/08/21 06:00
MHDA- 2013/08/08 06:00
CRDT- 2012/08/21 06:00
PHST- 2012/04/11 00:00 [received]
PHST- 2012/07/26 00:00 [accepted]
PHST- 2012/07/08 00:00 [revised]
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2013/08/08 06:00 [medline]
AID - 10.1007/s00330-012-2633-9 [doi]
PST - ppublish
SO  - Eur Radiol. 2013 Mar;23(3):845-54. doi: 10.1007/s00330-012-2633-9. Epub 2012 Aug 
      19.


PMID- 22903228
OWN - NLM
STAT- MEDLINE
DCOM- 20130118
LR  - 20180802
IS  - 1424-3997 (Electronic)
IS  - 0036-7672 (Linking)
VI  - 142
DP  - 2012
TI  - Controversies in the determination of death: perspectives from Switzerland.
PG  - w13667
LID - 10.4414/smw.2012.13667 [doi]
LID - Swiss Med Wkly. 2012;142:w13667 [pii]
AB  - In 1968, an Ad Hoc committee at the Harvard Medical School advanced new criteria 
      for determining death. It proposed that patients in irreversible coma with no
      discernible central nervous system activity were actually dead. The committee
      paved the way for the "whole brain" definition of death, which has reached broad 
      public acceptance and legal enactment in many countries. Despite this, the
      philosophical and ethical debate about the "whole brain" definition of death is
      far from being closed. This paper analyses the ongoing controversy and evaluates 
      the recent revision of the Swiss Academy of Medical Sciences guidelines for
      determining death.
FAU - Monteverde, S
AU  - Monteverde S
AD  - Institute of Biomedical Ethics, University of Zurich, Switzerland.
      settimio.monteverde@uzh.ch
FAU - Rid, A
AU  - Rid A
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120817
PL  - Switzerland
TA  - Swiss Med Wkly
JT  - Swiss medical weekly
JID - 100970884
SB  - IM
CIN - Swiss Med Wkly. 2013;143:w13782. PMID: 23740421
MH  - Brain Death/*diagnosis/legislation & jurisprudence
MH  - *Death
MH  - *Ethics, Medical
MH  - Humans
MH  - Practice Guidelines as Topic
MH  - Switzerland
MH  - Terminology as Topic
MH  - Tissue and Organ Procurement/ethics
EDAT- 2012/08/21 06:00
MHDA- 2013/01/19 06:00
CRDT- 2012/08/21 06:00
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2013/01/19 06:00 [medline]
AID - 10.4414/smw.2012.13667 [doi]
AID - smw-13667 [pii]
PST - epublish
SO  - Swiss Med Wkly. 2012 Aug 17;142:w13667. doi: 10.4414/smw.2012.13667. eCollection 
      2012.


PMID- 22902939
OWN - NLM
STAT- MEDLINE
DCOM- 20121017
LR  - 20191210
IS  - 1537-7385 (Electronic)
IS  - 0894-9115 (Linking)
VI  - 91
IP  - 9
DP  - 2012 Sep
TI  - Simplifying the 360-degree peer evaluation in a physical medicine and
      rehabilitation residency program.
PG  - 797-803
LID - 10.1097/PHM.0b013e3182645e63 [doi]
AB  - OBJECTIVE: A previous study determined that multiple questions on a 360-degree
      evaluation instrument were highly correlated, suggesting possible redundancy in
      what was being measured, and that some questions may be eliminated. The current
      study uses factor analysis and examines a larger data set to further explore this
      question. DESIGN: To evaluate the structure of the questionnaire, a factor
      analysis was performed on 3 yrs of data from a 19-item resident 360-degree
      evaluation. The number of factors was determined by examining the scree plot of
      eigenvalues for each item in the instrument, with a cutoff where the slope
      changes from rapid to slow decline. A reliability analysis was performed with the
      indicated number of factors, with deletion of each variable to evaluate its
      influence on overall reliability (Cronbach alpha). RESULTS: There were 299
      evaluations with complete responses to all 19 questions. The scree plot supported
      a single factor model. The reliability of the full, single factor survey was
      excellent (Cronbach alpha = 0.99). The three items with the highest loading on
      the factor were retained, which related to humanistic, moral/ethical, and
      professional responsibility behaviors. The reliability for these final three
      items remained excellent (Cronbach alpha = 0.96). CONCLUSIONS: The factor
      analysis suggests that one overall opinion of the evaluated resident was
      informing the responses of the evaluator. Shortening the instrument to the three 
      items responsible for the greatest influence on the survey does not result in a
      large decrease in reliability as measured by Cronbach alpha. It is possible that 
      time limitations prevent residents from putting thought into the evaluation of
      their peers, which results in unidimensional responses. Shortening the instrument
      may improve evaluations and should be studied in the future.
FAU - Sorg, John C
AU  - Sorg JC
AD  - MetroHealth Rehabilitation Institute of Ohio, Cleveland, OH 44109, USA.
FAU - Wilson, Richard D
AU  - Wilson RD
FAU - Perzynski, Adam T
AU  - Perzynski AT
FAU - Tran, Daniel
AU  - Tran D
FAU - Vargo, Mary M
AU  - Vargo MM
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - United States
TA  - Am J Phys Med Rehabil
JT  - American journal of physical medicine & rehabilitation
JID - 8803677
SB  - IM
MH  - Factor Analysis, Statistical
MH  - Female
MH  - Humans
MH  - Internship and Residency/*organization & administration
MH  - Male
MH  - Ohio
MH  - Peer Review/*methods
MH  - Physical and Rehabilitation Medicine/*education
MH  - Reproducibility of Results
MH  - Surveys and Questionnaires
EDAT- 2012/08/21 06:00
MHDA- 2012/10/18 06:00
CRDT- 2012/08/21 06:00
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2012/10/18 06:00 [medline]
AID - 10.1097/PHM.0b013e3182645e63 [doi]
AID - 00002060-201209000-00008 [pii]
PST - ppublish
SO  - Am J Phys Med Rehabil. 2012 Sep;91(9):797-803. doi: 10.1097/PHM.0b013e3182645e63.


PMID- 22902385
OWN - NLM
STAT- MEDLINE
DCOM- 20140113
LR  - 20130717
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 8
DP  - 2013 Aug
TI  - Double-effect reasoning and the conception of human embryos.
PG  - 529-32
LID - 10.1136/medethics-2012-100534 [doi]
AB  - Some commentators argue that conception signals the onset of human personhood and
      that moral responsibilities toward zygotic or embryonic persons begin at this
      point, not the least of which is to protect them from exposure to death. Critics 
      of the conception threshold of personhood ask how it can be morally consistent to
      object to the embryo loss that occurs in fertility medicine and research but not 
      object to the significant embryo loss that occurs through conception in vivo.
      Using that apparent inconsistency as a starting point, they argue that if that
      embryo loss is tolerable as a way of conceiving children, it should be tolerable 
      in fertility medicine and human embryonic research. Double-effect reasoning
      shows, by contrast, that conception in vivo is justified even if it involves the 
      death of persons because the motives for wanting children are not inherently
      objectionable, because the embryo loss that occurs in unassisted conception is
      not the means by which successful conception occurs, and because the effect of
      having children is proportionate to the loss involved. A similar outcome holds
      true for in vitro fertilisation in fertility medicine but not for in vitro
      fertilisation for research involving human embryos.
FAU - Murphy, Timothy F
AU  - Murphy TF
AD  - Medical Education mc 591, University of Illinois College of Medicine, Chicago, IL
      60612-7309, USA. tmurphy@uic.edu
LA  - eng
PT  - Journal Article
DEP - 20120818
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
CIN - J Med Ethics. 2013 Aug;39(8):533-6. PMID: 23139393
MH  - Beginning of Human Life/*ethics
MH  - *Embryo Loss
MH  - Embryo Research/*ethics
MH  - *Embryo, Mammalian
MH  - *Embryonic Development
MH  - *Fertilization
MH  - Fertilization in Vitro/*ethics
MH  - Humans
MH  - *Moral Obligations
MH  - *Personhood
MH  - Research Embryo Creation/ethics
OTO - NOTNLM
OT  - Embryos and Fetuses
OT  - Reproductive Medicine
OT  - Research Ethics
EDAT- 2012/08/21 06:00
MHDA- 2014/01/15 06:00
CRDT- 2012/08/21 06:00
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2014/01/15 06:00 [medline]
AID - medethics-2012-100534 [pii]
AID - 10.1136/medethics-2012-100534 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Aug;39(8):529-32. doi: 10.1136/medethics-2012-100534. Epub
      2012 Aug 18.


PMID- 22902289
OWN - NLM
STAT- MEDLINE
DCOM- 20130521
LR  - 20141021
IS  - 1532-2688 (Electronic)
IS  - 1059-1311 (Linking)
VI  - 21
IP  - 10
DP  - 2012 Dec
TI  - The use of high frequency oscillations to guide neocortical resections in
      children with medically-intractable epilepsy: how do we ethically apply surgical 
      innovations to patient care?
PG  - 743-7
LID - 10.1016/j.seizure.2012.07.013 [doi]
LID - S1059-1311(12)00190-2 [pii]
AB  - PURPOSE: Resective surgical strategies are increasingly applied to treat
      medically-intractable epilepsy in children as uncontrolled seizures are
      associated with poor cognitive, developmental and behavioral outcomes. Innovative
      surgical strategies are, however, needed to improve outcomes and minimize the
      morbidity of such procedures. METHOD: The current article utilizes an axiological
      approach to explore and highlight ethical issues in the use of high frequency
      oscillations (HFOs) to guide surgical resections in children with
      medically-intractable epilepsy. We frame our discussion in the context of the
      broader challenges in the application of surgical innovation to patient care.
      RESULTS: Despite a paucity of knowledge regarding their pathogenesis, limited
      evidence suggests the use of HFOs as biomarkers of epileptogenicity in resective 
      procedures can improve seizure outcome. Clinicians must therefore weigh
      deficiencies in knowledge against the limited evidence supporting the utility of 
      HFOs and make ethical decisions for the treatment of individual patients.
      Important ethical considerations for clinicians include the extent of deviation
      from established practice, the extent of evidence required to establish clinical 
      validity, and the impact of technique implementation on equitable distribution of
      healthcare. CONCLUSION: The use of HFO signatures to guide neocortical resections
      represents a novel approach for the treatment of epilepsy. It is hoped that the
      issues discussed herein will contribute to and advance meaningful dialog on the
      ethical application of this surgical innovation to the treatment of a very
      vulnerable patient population.
CI  - Copyright (c) 2012 British Epilepsy Association. Published by Elsevier Ltd. All
      rights reserved.
FAU - Ibrahim, George M
AU  - Ibrahim GM
AD  - Division of Neurosurgery, Hospital for Sick Children and Toronto Western
      Hospital, Toronto, Ontario, Canada.
FAU - Fallah, Aria
AU  - Fallah A
FAU - Snead, O Carter 3rd
AU  - Snead OC 3rd
FAU - Drake, James M
AU  - Drake JM
FAU - Rutka, James T
AU  - Rutka JT
FAU - Bernstein, Mark
AU  - Bernstein M
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120815
PL  - England
TA  - Seizure
JT  - Seizure
JID - 9306979
SB  - IM
MH  - Anterior Temporal Lobectomy/*ethics/*methods
MH  - Electroencephalography
MH  - Epilepsy/*surgery
MH  - Humans
MH  - Neurology/*ethics
EDAT- 2012/08/21 06:00
MHDA- 2013/05/23 06:00
CRDT- 2012/08/21 06:00
PHST- 2012/05/28 00:00 [received]
PHST- 2012/07/24 00:00 [revised]
PHST- 2012/07/26 00:00 [accepted]
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2013/05/23 06:00 [medline]
AID - S1059-1311(12)00190-2 [pii]
AID - 10.1016/j.seizure.2012.07.013 [doi]
PST - ppublish
SO  - Seizure. 2012 Dec;21(10):743-7. doi: 10.1016/j.seizure.2012.07.013. Epub 2012 Aug
      15.


PMID- 22902226
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20130628
IS  - 1879-1131 (Electronic)
IS  - 0738-081X (Linking)
VI  - 30
IP  - 5
DP  - 2012 Sep-Oct
TI  - Ethical issues regarding caring for dermatology patients in the U.S. Department
      of Veterans Affairs Health Care System.
PG  - 533-9
LID - 10.1016/j.clindermatol.2011.06.025 [doi]
AB  - The U.S. Department of Veterans Affairs (VA) operates the largest integrated
      health care system within the United States. VA budgets continue to escalate in
      an environment of heightened financial prudence and accountability. Despite
      having received many awards in areas from patient satisfaction and safety to
      product innovations, like any health care system, the VA is not immune to ethical
      conflict that requires exploration and evaluation. Several VA dermatologists,
      including section chiefs, were interviewed, and their responses to ethical
      complexities encountered or anticipated were analyzed in fictional case
      scenarios. Five morally concerning issues were highlighted. These include (1)
      providing care in a teaching setting with limited resources to a patient
      population with few other health care alternatives; (2) stereotyping patients,
      altogether an uncommon act, is possibly easier to do in the VA and has the
      potential to negatively affect patient care; (3) service-related disability claim
      cases often include medical opinion and findings documented in the medical record
      when judgments are made, thus the VA physician can have a significant effect on
      the outcome of these claims; (4) whether the VA provides a setting for apathetic 
      physicians to thrive or instead allows for a more meaningful work experience and 
      then how to manage the subpar performer; (5) except for the treatment of HIV
      lipodystrophy with injectables, primary cosmetic procedures are prohibited at the
      VA and can lead to difficulties for the VA dermatologist attempting to comply in 
      a era where dermatology is being more closely associated with cosmesis.
CI  - Published by Elsevier Inc.
FAU - Reich, Reuben
AU  - Reich R
AD  - New York Medical College, 40 Sunshine Cottage Road, Valhalla, NY 10595, USA.
FAU - Stevens, Emily
AU  - Stevens E
FAU - Dellavalle, Robert P
AU  - Dellavalle RP
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Clin Dermatol
JT  - Clinics in dermatology
JID - 8406412
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Bioethical Issues
MH  - Dermatology/ethics
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Skin Diseases/diagnosis/therapy
MH  - United States
MH  - *United States Department of Veterans Affairs
EDAT- 2012/08/21 06:00
MHDA- 2012/11/14 06:00
CRDT- 2012/08/21 06:00
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
AID - S0738-081X(11)00165-9 [pii]
AID - 10.1016/j.clindermatol.2011.06.025 [doi]
PST - ppublish
SO  - Clin Dermatol. 2012 Sep-Oct;30(5):533-9. doi: 10.1016/j.clindermatol.2011.06.025.


PMID- 22902225
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20130628
IS  - 1879-1131 (Electronic)
IS  - 0738-081X (Linking)
VI  - 30
IP  - 5
DP  - 2012 Sep-Oct
TI  - The ethical controversies of office-based dispensing in academic health centers.
PG  - 528-32
LID - 10.1016/j.clindermatol.2011.06.024 [doi]
AB  - Office dispensing of cosmecuticals has become a widespread practice in private
      dermatology offices and even has begun to appear in academic dermatology
      settings. Proponents of the practice state that in-office dispensing is
      beneficial for the patient and the physician and can be ethically accomplished
      with the patient remaining the primary concern of the care provider. This
      requires the maintenance of professionalism and the sale of efficacious,
      reasonably priced products that are not misrepresented. Opponents believe that
      in-office dispensing undermines the physician- patient relationship and may
      produce an inherent conflict of interest. In academia, additional concerns
      include how students and residents perceive this activity. Does selling products 
      negatively affect professionalism in an academic environment? In an academic
      teaching environment there is a paramount need to model ethical behavior to
      medical students and residents. We will discuss the opposition and
      rationalization for the practice of in-office dispensing in academic teaching
      settings.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Whitaker-Worth, Diane
AU  - Whitaker-Worth D
AD  - Department of Dermatology, University of Connecticut Health Center, 21 South
      Road, Farmington, CT 06030-6231, USA.
FAU - Shahriari, Mona
AU  - Shahriari M
FAU - Slade, Karren
AU  - Slade K
FAU - Grant-Kels, Jane M
AU  - Grant-Kels JM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Dermatol
JT  - Clinics in dermatology
JID - 8406412
RN  - 0 (Dermatologic Agents)
SB  - IM
MH  - *Academic Medical Centers
MH  - *Bioethical Issues
MH  - Dermatologic Agents/*supply & distribution
MH  - Dermatology/*ethics
MH  - Humans
MH  - *Office Visits
EDAT- 2012/08/21 06:00
MHDA- 2012/11/14 06:00
CRDT- 2012/08/21 06:00
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
AID - S0738-081X(11)00164-7 [pii]
AID - 10.1016/j.clindermatol.2011.06.024 [doi]
PST - ppublish
SO  - Clin Dermatol. 2012 Sep-Oct;30(5):528-32. doi:
      10.1016/j.clindermatol.2011.06.024.


PMID- 22902224
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20130628
IS  - 1879-1131 (Electronic)
IS  - 0738-081X (Linking)
VI  - 30
IP  - 5
DP  - 2012 Sep-Oct
TI  - Ethics in cosmetic dermatology.
PG  - 522-7
LID - 10.1016/j.clindermatol.2011.06.023 [doi]
AB  - The dispensing of nonprescription skin products by dermatologists and the
      performance of ineffective cosmetic procedures are the most controversial
      subjects associated with the practice of cosmetic dermatology. These topics have 
      been hotly debated within the profession for several decades, with each side
      presenting cogent arguments. The debate is also characterized by strong passion
      and emotions on both sides that are not easily reconciled. Dermatologists and
      their patients are best served by an objective, organized approach to clearly
      delineating the various aspects of these issues and providing guidelines for
      practitioners that can be shared with patients.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Baumann, Leslie
AU  - Baumann L
AD  - Baumann Cosmetic and Research Institute, Miami Beach, FL 33140-2910, USA.
      drb@derm.net.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Clin Dermatol
JT  - Clinics in dermatology
JID - 8406412
SB  - IM
MH  - Adult
MH  - *Bioethical Issues
MH  - Cosmetic Techniques/*ethics/standards
MH  - Dermatology/ethics
MH  - Female
MH  - Humans
MH  - Melanosis/*therapy
MH  - Office Visits
EDAT- 2012/08/21 06:00
MHDA- 2012/11/14 06:00
CRDT- 2012/08/21 06:00
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
AID - S0738-081X(11)00163-5 [pii]
AID - 10.1016/j.clindermatol.2011.06.023 [doi]
PST - ppublish
SO  - Clin Dermatol. 2012 Sep-Oct;30(5):522-7. doi: 10.1016/j.clindermatol.2011.06.023.


PMID- 22902223
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20181201
IS  - 1879-1131 (Electronic)
IS  - 0738-081X (Linking)
VI  - 30
IP  - 5
DP  - 2012 Sep-Oct
TI  - Ethics of utilizing nurse practitioners and physician's assistants in the
      dermatology setting.
PG  - 516-21
LID - 10.1016/j.clindermatol.2011.06.022 [doi]
AB  - Our current supply of dermatologists in training is insufficient to meet the
      growing demand for dermatology services. In an era of declining reimbursements
      and the ever increasing clamor for increased access to care, many practices are
      turning to nurse practitioners and physician assistants as a cost effective means
      of fulfilling patient demand. Despite the recommendations of the American Academy
      of Dermatology, there is no explicit consensus among dermatologists on the
      educational requirements or appropriate utilization of NPs and PAs in dermatology
      settings. Colleges of nursing and physician assistant programs recognize the
      provider demand in dermatology and have begun to implement training programs to
      address the need for specialty training. Academic settings offer a unique
      opportunity for NPs and PAs to receive a medically oriented grounding in basic
      science, dermatopathology, and research.
CI  - Copyright (c) 2012. Published by Elsevier Inc.
FAU - Slade, Karren
AU  - Slade K
AD  - Department of Dermatology, University of Conneticut Health Center, 21 South Road,
      Farmington, CT 06032-6231, USA. slade@uchc.edu
FAU - Lazenby, Mark
AU  - Lazenby M
FAU - Grant-Kels, Jane M
AU  - Grant-Kels JM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Dermatol
JT  - Clinics in dermatology
JID - 8406412
SB  - IM
MH  - Dermatology/*ethics
MH  - Humans
MH  - Informed Consent
MH  - Nurse Practitioners/*ethics
MH  - Patient Rights
MH  - Physician Assistants/*ethics
MH  - Workforce
EDAT- 2012/08/21 06:00
MHDA- 2012/11/14 06:00
CRDT- 2012/08/21 06:00
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
AID - S0738-081X(11)00162-3 [pii]
AID - 10.1016/j.clindermatol.2011.06.022 [doi]
PST - ppublish
SO  - Clin Dermatol. 2012 Sep-Oct;30(5):516-21. doi:
      10.1016/j.clindermatol.2011.06.022.


PMID- 22902222
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20130628
IS  - 1879-1131 (Electronic)
IS  - 0738-081X (Linking)
VI  - 30
IP  - 5
DP  - 2012 Sep-Oct
TI  - Ethical issues in geriatric dermatology.
PG  - 511-5
LID - 10.1016/j.clindermatol.2011.06.021 [doi]
AB  - Physicians should be cognizant of the multitude of unique issues that their
      geriatric patients present and aware of the overall elder patient's general
      health status both physically and cognitively, potential drug interactions, and
      their short-term as well as long-term goals. While respecting patients' autonomy,
      we must evaluate their ability to make their own decisions regarding their health
      care. This will require time and patience on our part. We also must overcome our 
      own potential prejudices about what we view as important for the older patient.
      Finally, we may need to appropriate involve family members or caregivers in the
      decision-making processes and care of our elderly patients. To properly and
      ethically care for this distinct and vulnerable population, with their myriad of 
      complex issues, it is important that dermatologists understand their unique
      issues and challenges.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Fontanella, Demian
AU  - Fontanella D
AD  - Department of Dermatology, University of Connecticut Health Center, 21 South
      Road, Farmington, CT 06030-6231, USA.
FAU - Grant-Kels, Jane M
AU  - Grant-Kels JM
FAU - Patel, Trupal
AU  - Patel T
FAU - Norman, Robert
AU  - Norman R
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Clin Dermatol
JT  - Clinics in dermatology
JID - 8406412
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Amputation
MH  - Beneficence
MH  - *Bioethical Issues
MH  - Carcinoma, Basal Cell/*therapy
MH  - Dermatology/ethics
MH  - Female
MH  - Foot/*pathology/*surgery
MH  - Foot Diseases/*pathology/*surgery
MH  - Gangrene/surgery
MH  - Geriatrics/ethics
MH  - Head and Neck Neoplasms/*therapy
MH  - Humans
MH  - Personal Autonomy
MH  - Skin Neoplasms/*therapy
EDAT- 2012/08/21 06:00
MHDA- 2012/11/14 06:00
CRDT- 2012/08/21 06:00
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
AID - S0738-081X(11)00161-1 [pii]
AID - 10.1016/j.clindermatol.2011.06.021 [doi]
PST - ppublish
SO  - Clin Dermatol. 2012 Sep-Oct;30(5):511-5. doi: 10.1016/j.clindermatol.2011.06.021.


PMID- 22902221
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20130628
IS  - 1879-1131 (Electronic)
IS  - 0738-081X (Linking)
VI  - 30
IP  - 5
DP  - 2012 Sep-Oct
TI  - Ethical issues in cutaneous melanoma.
PG  - 501-10
LID - 10.1016/j.clindermatol.2011.06.020 [doi]
AB  - Early diagnosis of cutaneous melanoma (CM) is associated with the finding of
      superficial tumors resulting in high cure rates with surgery, whereas those with 
      deeply invasive tumors are at higher risk of recurrence and melanoma-specific
      mortality. Unfortunately, once metastatic to the visceral organs, CM is usually
      refractory to the presently available treatment modalities, resulting in
      uniformly poor outcomes in patients. Educating susceptible populations about the 
      risk of developing CM has played an important role in preventive strategies
      despite the fact that benefits of primary skin screening are controversial.
      Although a number of reliable prognostic factors are recognized, clinical
      unpredictability is reflected by a small but significant proportion of patients
      who experience adverse outcomes from CM, even though lacking the known poor
      prognostic markers. Because CM is an immunogenic tumor, most of the new
      treatments have engaged in harnessing antimelanoma immunity, and recent advances 
      in genomics have led to promising targeted therapies. A number of ethical issues 
      have confronted health care providers when taking care of CM patients in
      different stages of the disease, which have included areas of primary prevention,
      early diagnosis, strategies to reduce recurrence of the tumor, and managing
      patients with advanced tumors. With the increasing incidence of CM in
      fair-skinned people, as well as the increasing recognition of CM in nonwhites,
      addressing the discussed ethical issues will be even more challenging and
      important as we provide comprehensive management of this disease.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Hegde, Upendra P
AU  - Hegde UP
AD  - Carole and Ray Neag Cancer Center, University of Connecticut Health Center, 263
      Farmington Avenue, Farmington, CT 06030, USA. uhegde@uchc.edu
FAU - Grant-Kels, Jane M
AU  - Grant-Kels JM
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Clin Dermatol
JT  - Clinics in dermatology
JID - 8406412
SB  - IM
MH  - Adult
MH  - Aged, 80 and over
MH  - *Bioethical Issues
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Male
MH  - Melanoma/*diagnosis/*therapy
MH  - Skin Neoplasms/*diagnosis/*therapy
EDAT- 2012/08/21 06:00
MHDA- 2012/11/14 06:00
CRDT- 2012/08/21 06:00
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
AID - S0738-081X(11)00160-X [pii]
AID - 10.1016/j.clindermatol.2011.06.020 [doi]
PST - ppublish
SO  - Clin Dermatol. 2012 Sep-Oct;30(5):501-10. doi:
      10.1016/j.clindermatol.2011.06.020.


PMID- 22902220
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20130628
IS  - 1879-1131 (Electronic)
IS  - 0738-081X (Linking)
VI  - 30
IP  - 5
DP  - 2012 Sep-Oct
TI  - Ethical issues in inpatient consultative dermatology.
PG  - 496-500
LID - 10.1016/j.clindermatol.2011.06.019 [doi]
AB  - Ethical issues commonly arise in inpatient dermatology consultations. We describe
      the case of an inpatient suffering from a severe, undiagnosable skin condition
      that raises key principles of medical ethics. The four principles include
      autonomy, nonmaleficence, beneficence, and justice. Ethical situations faced by
      inpatient dermatologists are similar to those experienced by medicine
      hospitalists, as compared with outpatient dermatologists, given the unique
      clinical setting in which inpatient dermatology is practiced. Other inpatient
      services, colleagues, and ethics committees are useful resources for inpatient
      dermatologists faced with difficult ethical situations.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Hansra, Nina K
AU  - Hansra NK
AD  - Department of Dermatology, University of California at San Francisco School of
      Medicine, 1701 Divisadero Street, San Francisco, CA 94143-0316, USA.
FAU - Shinkai, Kanade
AU  - Shinkai K
FAU - Fox, Lindy P
AU  - Fox LP
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Clin Dermatol
JT  - Clinics in dermatology
JID - 8406412
SB  - IM
MH  - *Bioethical Issues
MH  - Dermatology/ethics
MH  - Female
MH  - Humans
MH  - *Inpatients
MH  - *Lupus Erythematosus, Discoid/diagnosis/therapy
MH  - Middle Aged
EDAT- 2012/08/21 06:00
MHDA- 2012/11/14 06:00
CRDT- 2012/08/21 06:00
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
AID - S0738-081X(11)00159-3 [pii]
AID - 10.1016/j.clindermatol.2011.06.019 [doi]
PST - ppublish
SO  - Clin Dermatol. 2012 Sep-Oct;30(5):496-500. doi:
      10.1016/j.clindermatol.2011.06.019.


PMID- 22902219
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20131121
IS  - 1879-1131 (Electronic)
IS  - 0738-081X (Linking)
VI  - 30
IP  - 5
DP  - 2012 Sep-Oct
TI  - Ethical considerations when prescribing biologics in dermatology.
PG  - 492-5
LID - 10.1016/j.clindermatol.2011.06.018 [doi]
AB  - There are no formal publications describing and discussing the various ethical
      dilemmas encountered when treating dermatologic disease with biologic therapy.
      Multiple issues such as safety, efficacy, drug accessibility, and cost need to be
      considered when prescribing biologics. This contribution uses a case-based
      approach to evaluate the ethical principles involved with biologic therapy.
CI  - Copyright (c) 2012. Published by Elsevier Inc.
FAU - Santoro, Frank A
AU  - Santoro FA
AD  - Department of Dermatology, University of Connecticut Health Center, 21 South
      Road, Farmington, CT 06030-6231, USA.
FAU - Rothe, Marti J
AU  - Rothe MJ
FAU - Strober, Bruce E
AU  - Strober BE
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Clin Dermatol
JT  - Clinics in dermatology
JID - 8406412
RN  - 0 (Biological Products)
SB  - IM
MH  - Adult
MH  - Beneficence
MH  - *Bioethical Issues
MH  - Biological Products/*therapeutic use
MH  - Dermatology/ethics
MH  - Humans
MH  - Male
MH  - Psoriasis/*drug therapy
MH  - Pyoderma Gangrenosum/*drug therapy
EDAT- 2012/08/21 06:00
MHDA- 2012/11/14 06:00
CRDT- 2012/08/21 06:00
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
AID - S0738-081X(11)00158-1 [pii]
AID - 10.1016/j.clindermatol.2011.06.018 [doi]
PST - ppublish
SO  - Clin Dermatol. 2012 Sep-Oct;30(5):492-5. doi: 10.1016/j.clindermatol.2011.06.018.


PMID- 22902218
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20220316
IS  - 1879-1131 (Electronic)
IS  - 0738-081X (Linking)
VI  - 30
IP  - 5
DP  - 2012 Sep-Oct
TI  - Ethical considerations in dermatologic photography.
PG  - 486-91
LID - 10.1016/j.clindermatol.2011.06.017 [doi]
AB  - In dermatology, clinical photographs are an essential component of patient care, 
      enabling clinicians to document changes in skin pathology over time. Recent
      advances in digital technology and the electronic medical record have
      revolutionized clinical photography; however, these advances bring with them new 
      ethical, legal, and social concerns. Photographs, more than other forms of
      documentation, have the potential to make patients uncomfortable. The act of
      photography, especially for those images requiring exposure of the genital area
      or the entire body, can be an uncomfortable experience for patients,
      necessitating the clinician and photographer to take an empathic stance in this
      setting. The Internet has elicited an increasing, and a very real, concern for
      patients about possible distribution and use of images outside of their
      individual care. The clinician and staff can allay these fears by professionally 
      and empathetically addressing their concerns. In addition, it is important that
      patients receive appropriate informed consent about clinical photographs and the 
      potential use of the images in their care, education, and research. Given the
      multitude of methods for recording clinical photographs, combined with the
      increasing complexity of image storage, standardization becomes a critical tool
      in providing consistency among images and achieving more equitable and
      efficacious care. To achieve this goal and improve the baseline standard of
      continuity of care for dermatological practices, we review the role of
      photographs, develop a model for patient consent, and establish standards for
      photography so as to provide the most ethical care for the patient.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Lakdawala, Nikita
AU  - Lakdawala N
AD  - Department of Dermatology, University of Connecticut Health Center, 21 South
      Road, Farmington, CT 06030-6231, USA.
FAU - Fontanella, Demian
AU  - Fontanella D
FAU - Grant-Kels, Jane M
AU  - Grant-Kels JM
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Clin Dermatol
JT  - Clinics in dermatology
JID - 8406412
SB  - IM
MH  - *Bioethical Issues
MH  - Child, Preschool
MH  - Confidentiality
MH  - Dermatology/ethics
MH  - Genitalia, Male
MH  - Humans
MH  - Informed Consent
MH  - Male
MH  - Nevus, Pigmented/*pathology
MH  - Photography/*ethics
MH  - Skin Neoplasms/*pathology
EDAT- 2012/08/21 06:00
MHDA- 2012/11/14 06:00
CRDT- 2012/08/21 06:00
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
AID - S0738-081X(11)00157-X [pii]
AID - 10.1016/j.clindermatol.2011.06.017 [doi]
PST - ppublish
SO  - Clin Dermatol. 2012 Sep-Oct;30(5):486-91. doi:
      10.1016/j.clindermatol.2011.06.017.


PMID- 22902217
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20130628
IS  - 1879-1131 (Electronic)
IS  - 0738-081X (Linking)
VI  - 30
IP  - 5
DP  - 2012 Sep-Oct
TI  - Ethical dilemmas in dermatologic surgery.
PG  - 482-5
LID - 10.1016/j.clindermatol.2011.06.016 [doi]
AB  - Dermatologic surgery presents a unique set of ethical dilemmas not frequently
      discussed within the medical literature. This contribution presents a few cases
      commonly encountered by dermatologic surgeons. The case-based discussion follows 
      a principles-based framework for analysis and seeks to identify the central moral
      conflict and exemplify the development of sound reasoning for subsequent decision
      making through the consideration of multiple viewpoints and the weighing of
      potential consequences. Additional cases are provided in concise format to
      encourage further analysis and discourse on the distinct ethical dilemmas
      encountered within dermatologic surgery.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Holmes, William D
AU  - Holmes WD
AD  - Department of Dermatology, University of Connecticut Health Center, 21 South
      Road, Farmington, CT 06030-6231, USA. wholmes@resident.uchc.edu
FAU - Whalen, James D
AU  - Whalen JD
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Clin Dermatol
JT  - Clinics in dermatology
JID - 8406412
SB  - IM
MH  - Adult
MH  - *Bioethical Issues
MH  - Dermatology/ethics
MH  - Humans
MH  - Male
MH  - Nevus/*surgery
MH  - Specialties, Surgical/ethics
EDAT- 2012/08/21 06:00
MHDA- 2012/11/14 06:00
CRDT- 2012/08/21 06:00
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
AID - S0738-081X(11)00156-8 [pii]
AID - 10.1016/j.clindermatol.2011.06.016 [doi]
PST - ppublish
SO  - Clin Dermatol. 2012 Sep-Oct;30(5):482-5. doi: 10.1016/j.clindermatol.2011.06.016.


PMID- 22902216
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20130628
IS  - 1879-1131 (Electronic)
IS  - 0738-081X (Linking)
VI  - 30
IP  - 5
DP  - 2012 Sep-Oct
TI  - Ethical issues in dermatopathology.
PG  - 476-81
LID - 10.1016/j.clindermatol.2011.06.015 [doi]
AB  - Some of the most contentious and relevant ethical issues in dermatopathology
      include client billing, the practice of dermatopathology by physicians without
      board certification in dermatopathology, and the practice of including
      recommendations regarding further surgery in dermatopathology reports. Client
      billing is a system in which clinicians directly compensate laboratories for
      pathology services and directly bill patients and/or third-party payers. Although
      proponents argue that this system can reduce health care costs and increase
      efficiency, others have argued that it creates an environment that fosters
      unethical, and potentially illegal, behavior. The development of various types of
      laboratory models, commonly referred to as "contractual joint ventures," has
      served to expand client billing. Although the field of dermatopathology is
      considered a subspecialty of both clinical dermatology and anatomic pathology,
      dermatopathology is commonly practiced by clinical dermatologists and general
      anatomic pathologists who are not board certified in dermatopathology. Although
      these physicians are legally entitled to practice dermatopathology, some have
      questioned the ethics of this situation, especially when board-certified
      dermatopathologists are available. Finally, dermatopathology reports, on
      occasion, include suggestions regarding the need for additional surgery or other 
      clinical courses of action. Although established guidelines do not fully endorse 
      or discourage this practice, various opinions exist regarding its affect on
      patient care.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Wiland, Homer O 4th
AU  - Wiland HO 4th
AD  - Department of Anatomic and Clinical Pathology and Laboratory Medicine, Cleveland 
      Clinic Foundation, 9500 Euclid Avenue/L25, Cleveland, OH 44195, USA.
FAU - Grant-Kels, Jane M
AU  - Grant-Kels JM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Dermatol
JT  - Clinics in dermatology
JID - 8406412
SB  - IM
MH  - *Bioethical Issues
MH  - Dermatology/*ethics
MH  - Humans
MH  - Pathology/*ethics
EDAT- 2012/08/21 06:00
MHDA- 2012/11/14 06:00
CRDT- 2012/08/21 06:00
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
AID - S0738-081X(11)00155-6 [pii]
AID - 10.1016/j.clindermatol.2011.06.015 [doi]
PST - ppublish
SO  - Clin Dermatol. 2012 Sep-Oct;30(5):476-81. doi:
      10.1016/j.clindermatol.2011.06.015.


PMID- 22902215
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20130628
IS  - 1879-1131 (Electronic)
IS  - 0738-081X (Linking)
VI  - 30
IP  - 5
DP  - 2012 Sep-Oct
TI  - Ethics in pediatric dermatology.
PG  - 471-5
LID - 10.1016/j.clindermatol.2011.06.014 [doi]
AB  - The patient-parent-physician relationship is central to studying medical ethics
      in pediatric dermatology. The rights of children in medical decision making are
      ambiguous, and parents and physicians will often override the autonomy of a child
      when a particular treatment is deemed to be in the child's best interest. The use
      of physical restraint to enforce a treatment should be justified, and a
      reasonable attempt should be made to ensure the cooperation of the child, if
      possible. Medical photography is central to the practice of pediatric dermatology
      in that it allows for serial observation of cutaneous lesions over time.
      Established guidelines and standards should be followed. Pediatric dermatologists
      frequently prescribe medications off-label; if following established professional
      standards, and prescribing with good intention, off-label prescribing can be
      appropriate and rational.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Kelly, John B 3rd
AU  - Kelly JB 3rd
AD  - University of Connecticut School of Medicine, Farmington, CT, USA.
FAU - Makkar, Hanspaul S
AU  - Makkar HS
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Clin Dermatol
JT  - Clinics in dermatology
JID - 8406412
SB  - IM
MH  - *Bioethical Issues
MH  - Dermatology/ethics
MH  - *Drug Prescriptions
MH  - Hemangioma/*drug therapy
MH  - Humans
MH  - Infant
MH  - Male
MH  - Pediatrics/ethics
MH  - United States
EDAT- 2012/08/21 06:00
MHDA- 2012/11/14 06:00
CRDT- 2012/08/21 06:00
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
AID - S0738-081X(11)00154-4 [pii]
AID - 10.1016/j.clindermatol.2011.06.014 [doi]
PST - ppublish
SO  - Clin Dermatol. 2012 Sep-Oct;30(5):471-5. doi: 10.1016/j.clindermatol.2011.06.014.


PMID- 22902214
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20130628
IS  - 1879-1131 (Electronic)
IS  - 0738-081X (Linking)
VI  - 30
IP  - 5
DP  - 2012 Sep-Oct
TI  - Ethics in the dermatology clinic: Part II.
PG  - 469-70
LID - 10.1016/j.clindermatol.2011.06.028 [doi]
FAU - Grant-Kels, Jane M
AU  - Grant-Kels JM
AD  - Department of Dermatology, University of Connecticut Health Center, 21 South
      Road, Farmington, CT 06030-6231, USA. grant@uchc.edu
LA  - eng
PT  - Introductory Journal Article
PL  - United States
TA  - Clin Dermatol
JT  - Clinics in dermatology
JID - 8406412
SB  - IM
MH  - Dermatology/*ethics
MH  - Humans
MH  - United States
EDAT- 2012/08/21 06:00
MHDA- 2012/11/14 06:00
CRDT- 2012/08/21 06:00
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
AID - S0738-081X(11)00168-4 [pii]
AID - 10.1016/j.clindermatol.2011.06.028 [doi]
PST - ppublish
SO  - Clin Dermatol. 2012 Sep-Oct;30(5):469-70. doi:
      10.1016/j.clindermatol.2011.06.028.


PMID- 22902171
OWN - NLM
STAT- MEDLINE
DCOM- 20130429
LR  - 20191210
IS  - 0035-3787 (Print)
IS  - 0035-3787 (Linking)
VI  - 168
IP  - 11
DP  - 2012 Nov
TI  - Neuroprevention: a new challenge?
PG  - 796-801
LID - 10.1016/j.neurol.2012.07.001 [doi]
LID - S0035-3787(12)00880-6 [pii]
AB  - Neurodegenerative disease (NDD) has become the leading cause of disability and
      dependency in Western and European societies. Treatments, when available, are
      symptomatic, and their efficacy is usually poor or decreases with disease
      progression. So far, no treatment can effectively modify NDD, partly because of
      the inevitable delay between the onset of the pathological process and
      therapeutic intervention. The ideal strategy would be to stop the pathological
      process before neurons degenerate - in other words, before symptoms. However, to 
      do this, the populations at high risk of developing NDD need to be identified.
      Predicting the appearance of NDD encounters two main issues. The first is to
      accurately determine the very beginning of the neurodegenerative process and to
      follow its course; the second is to determine those populations at high risk of
      developing NDD. Several approaches have been proposed to identify presymptomatic 
      markers, including the refinement of the semiology in the early stages of the
      disease and/or the prospective follow-up of asymptomatic carriers of the genetic 
      form of NDD in particular. To predict the onset of NDD at the asymptomatic stage,
      however, raises ethical issues at a time when no preventative medication is as
      yet available.
CI  - Copyright (c) 2012. Published by Elsevier Masson SAS.
FAU - Corvol, J-C
AU  - Corvol JC
AD  - Assistance publique hopitaux de Paris, hopital Pitie-Salpetriere, departement de 
      neurologie, 1 Paris cedex 13, France. jean-christophe.corvol@psl.aphp.fr
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Review
DEP - 20120814
PL  - France
TA  - Rev Neurol (Paris)
JT  - Revue neurologique
JID - 2984779R
RN  - 0 (Biomarkers)
RN  - 0 (Neuroprotective Agents)
SB  - IM
MH  - Biomarkers/analysis
MH  - Disease Progression
MH  - Early Diagnosis
MH  - Humans
MH  - Neurodegenerative Diseases/diagnosis/*prevention & control
MH  - Neuroprotective Agents/*therapeutic use
MH  - Prodromal Symptoms
MH  - Prognosis
EDAT- 2012/08/21 06:00
MHDA- 2013/04/30 06:00
CRDT- 2012/08/21 06:00
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2013/04/30 06:00 [medline]
AID - S0035-3787(12)00880-6 [pii]
AID - 10.1016/j.neurol.2012.07.001 [doi]
PST - ppublish
SO  - Rev Neurol (Paris). 2012 Nov;168(11):796-801. doi: 10.1016/j.neurol.2012.07.001. 
      Epub 2012 Aug 14.


PMID- 22901864
OWN - NLM
STAT- MEDLINE
DCOM- 20121015
LR  - 20220321
IS  - 1474-547X (Electronic)
IS  - 0140-6736 (Linking)
VI  - 380
IP  - 9849
DP  - 2012 Oct 6
TI  - The quest for universal health coverage: achieving social protection for all in
      Mexico.
PG  - 1259-79
LID - 10.1016/S0140-6736(12)61068-X [doi]
LID - S0140-6736(12)61068-X [pii]
AB  - Mexico is reaching universal health coverage in 2012. A national health insurance
      programme called Seguro Popular, introduced in 2003, is providing access to a
      package of comprehensive health services with financial protection for more than 
      50 million Mexicans previously excluded from insurance. Universal coverage in
      Mexico is synonymous with social protection of health. This report analyses the
      road to universal coverage along three dimensions of protection: against health
      risks, for patients through quality assurance of health care, and against the
      financial consequences of disease and injury. We present a conceptual discussion 
      of the transition from labour-based social security to social protection of
      health, which implies access to effective health care as a universal right based 
      on citizenship, the ethical basis of the Mexican reform. We discuss the
      conditions that prompted the reform, as well as its design and inception, and we 
      describe the 9-year, evidence-driven implementation process, including updates
      and improvements to the original programme. The core of the report concentrates
      on the effects and impacts of the reform, based on analysis of all published and 
      publically available scientific literature and new data. Evidence indicates that 
      Seguro Popular is improving access to health services and reducing the prevalence
      of catastrophic and impoverishing health expenditures, especially for the poor.
      Recent studies also show improvement in effective coverage. This research then
      addresses persistent challenges, including the need to translate financial
      resources into more effective, equitable and responsive health services. A next
      generation of reforms will be required and these include systemic measures to
      complete the reorganisation of the health system by functions. The paper
      concludes with a discussion of the implications of the Mexican quest to achieve
      universal health coverage and its relevance for other low-income and
      middle-income countries.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Knaul, Felicia Marie
AU  - Knaul FM
AD  - Harvard Global Equity Initiative, Boston, MA, USA. felicia_knaul@harvard.edu
FAU - Gonzalez-Pier, Eduardo
AU  - Gonzalez-Pier E
FAU - Gomez-Dantes, Octavio
AU  - Gomez-Dantes O
FAU - Garcia-Junco, David
AU  - Garcia-Junco D
FAU - Arreola-Ornelas, Hector
AU  - Arreola-Ornelas H
FAU - Barraza-Llorens, Mariana
AU  - Barraza-Llorens M
FAU - Sandoval, Rosa
AU  - Sandoval R
FAU - Caballero, Francisco
AU  - Caballero F
FAU - Hernandez-Avila, Mauricio
AU  - Hernandez-Avila M
FAU - Juan, Mercedes
AU  - Juan M
FAU - Kershenobich, David
AU  - Kershenobich D
FAU - Nigenda, Gustavo
AU  - Nigenda G
FAU - Ruelas, Enrique
AU  - Ruelas E
FAU - Sepulveda, Jaime
AU  - Sepulveda J
FAU - Tapia, Roberto
AU  - Tapia R
FAU - Soberon, Guillermo
AU  - Soberon G
FAU - Chertorivski, Salomon
AU  - Chertorivski S
FAU - Frenk, Julio
AU  - Frenk J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120816
PL  - England
TA  - Lancet
JT  - Lancet (London, England)
JID - 2985213R
SB  - IM
RPI - Salud Publica Mex. 2013 Apr;55(2):207-35. PMID: 23546413
MH  - Financing, Personal
MH  - *Health Care Reform/organization & administration
MH  - Health Services Accessibility
MH  - Humans
MH  - Medically Uninsured
MH  - Mexico
MH  - *Universal Health Insurance/organization & administration
EDAT- 2012/08/21 06:00
MHDA- 2012/10/16 06:00
CRDT- 2012/08/21 06:00
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2012/10/16 06:00 [medline]
AID - S0140-6736(12)61068-X [pii]
AID - 10.1016/S0140-6736(12)61068-X [doi]
PST - ppublish
SO  - Lancet. 2012 Oct 6;380(9849):1259-79. doi: 10.1016/S0140-6736(12)61068-X. Epub
      2012 Aug 16.


PMID- 22901734
OWN - NLM
STAT- MEDLINE
DCOM- 20130604
LR  - 20120827
IS  - 1532-1932 (Electronic)
IS  - 1521-6934 (Linking)
VI  - 26
IP  - 5
DP  - 2012 Oct
TI  - Ethical issues in the diagnosis and management of fetal disorders.
PG  - 541-50
LID - 10.1016/j.bpobgyn.2012.06.003 [doi]
AB  - The ethics of diagnosis and management of fetal genetic disorders are
      particularly controversial because of the contested status of the fetus and
      perceptions of genetics. An additional complicating factor is the potential
      conflict between mother and fetus. Ethical issues in diagnosis include the nature
      and purpose of the diagnosis itself, and management of the information.
      Management of the disorder includes issues of termination as an option, and the
      emerging field of fetal gene therapy with associated issues of somatic versus
      germ-line interventions.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Chadwick, Ruth
AU  - Chadwick R
AD  - Cesagen, Cardiff University, Cardiff, Wales, UK. ChadwickR1@cardiff.ac.uk
FAU - Childs, Richardo
AU  - Childs R
LA  - eng
PT  - Journal Article
DEP - 20120814
PL  - Netherlands
TA  - Best Pract Res Clin Obstet Gynaecol
JT  - Best practice & research. Clinical obstetrics & gynaecology
JID - 101121582
SB  - IM
MH  - Abortion, Induced
MH  - Ethics, Medical
MH  - Female
MH  - Fetal Diseases/*diagnosis/genetics/therapy
MH  - Fetal Therapies/*ethics
MH  - Genetic Diseases, Inborn/diagnosis/therapy
MH  - Genetic Testing/*ethics
MH  - Genetic Therapy/*ethics
MH  - Humans
MH  - *Personal Autonomy
MH  - Pregnancy
MH  - Prenatal Diagnosis/*ethics
EDAT- 2012/08/21 06:00
MHDA- 2013/06/05 06:00
CRDT- 2012/08/21 06:00
PHST- 2012/05/24 00:00 [received]
PHST- 2012/06/14 00:00 [accepted]
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2013/06/05 06:00 [medline]
AID - S1521-6934(12)00099-5 [pii]
AID - 10.1016/j.bpobgyn.2012.06.003 [doi]
PST - ppublish
SO  - Best Pract Res Clin Obstet Gynaecol. 2012 Oct;26(5):541-50. doi:
      10.1016/j.bpobgyn.2012.06.003. Epub 2012 Aug 14.


PMID- 22901595
OWN - NLM
STAT- MEDLINE
DCOM- 20130101
LR  - 20220409
IS  - 1523-6838 (Electronic)
IS  - 0272-6386 (Linking)
VI  - 60
IP  - 4
DP  - 2012 Oct
TI  - The evolution of our knowledge of HIV-associated kidney disease in Africa.
PG  - 668-78
LID - 10.1053/j.ajkd.2012.04.034 [doi]
LID - S0272-6386(12)00953-5 [pii]
AB  - Human immunodeficiency virus (HIV) infection started in Africa circa 1930. South 
      Africa has the highest prevalence rate in the world. Although reports of
      HIV-associated nephropathy (HIVAN) appeared in the early 1980s, the earliest
      report from sub-Saharan Africa (SSA) came in 1994. Geographical, socioeconomic,
      political, and ethical factors have worked in concert to shape the character of
      HIV disease as it is seen in SSA. Political leaders within SSA have, through
      their actions, significantly contributed to the incidence of HIV infection. Black
      females, who often face cultural suppression and disadvantage, have a higher
      prevalence of HIV than males. Too few studies and outcomes data have bedeviled
      the statistics in SSA in relation to HIVAN prevalence and its management. Much of
      what is written is approximation and anecdotal. The largest reliable biopsy
      series comes from the University of Cape Town, where a workable classification of
      HIVAN has been developed to enable standardization of terminology. Histologic and
      clinical prognostic indicators with outcomes have been evaluated using this
      classification. Patients with HIV who present with acute kidney injury appear to 
      have mainly acute tubular necrosis due to sepsis, dehydration, and nephrotoxic
      drugs. Since the rollout of combination antiretroviral therapy, the extent of HIV
      infection and kidney disease continues to be modified and possibly retarded.
CI  - Copyright (c) 2012 National Kidney Foundation, Inc. Published by Elsevier Inc.
      All rights reserved.
FAU - Swanepoel, Charles R
AU  - Swanepoel CR
AD  - Division of Nephrology and Hypertension, Department of Medicine, Groote Schuur
      Hospital, Cape Town, South Africa. charles.swanepoel@uct.ac.za
FAU - Wearne, Nicola
AU  - Wearne N
FAU - Duffield, Maureen S
AU  - Duffield MS
FAU - Okpechi, Ikechi G
AU  - Okpechi IG
LA  - eng
PT  - Historical Article
PT  - Journal Article
DEP - 20120814
PL  - United States
TA  - Am J Kidney Dis
JT  - American journal of kidney diseases : the official journal of the National Kidney
      Foundation
JID - 8110075
RN  - 0 (Anti-Retroviral Agents)
SB  - IM
MH  - *AIDS-Associated Nephropathy/classification/epidemiology/pathology
MH  - Acute Kidney Injury/epidemiology
MH  - Africa/epidemiology
MH  - Africa South of the Sahara/epidemiology
MH  - Anti-Retroviral Agents/therapeutic use
MH  - Drug Therapy, Combination
MH  - HIV Infections/drug therapy/history
MH  - HIV-1
MH  - Health Expenditures
MH  - History, 20th Century
MH  - Humans
MH  - Incidence
MH  - Kidney Glomerulus/pathology
MH  - Kidney Tubular Necrosis, Acute/epidemiology
MH  - Prevalence
EDAT- 2012/08/21 06:00
MHDA- 2013/01/02 06:00
CRDT- 2012/08/21 06:00
PHST- 2011/09/20 00:00 [received]
PHST- 2012/04/24 00:00 [accepted]
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2013/01/02 06:00 [medline]
AID - S0272-6386(12)00953-5 [pii]
AID - 10.1053/j.ajkd.2012.04.034 [doi]
PST - ppublish
SO  - Am J Kidney Dis. 2012 Oct;60(4):668-78. doi: 10.1053/j.ajkd.2012.04.034. Epub
      2012 Aug 14.


PMID- 22901203
OWN - NLM
STAT- MEDLINE
DCOM- 20130122
LR  - 20190606
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Linking)
VI  - 13
IP  - 5
DP  - 2012
TI  - Serum amyloid a as an independent prognostic factor for renal cell carcinoma--a
      hospital based study from the Western region of Nepal.
PG  - 2253-5
AB  - OBJECTIVE: The objective of our present study was to assess the role of serum
      amyloid A (SAA) in stages and prognosis of renal cell carcinoma. MATERIAL AND
      METHODS: It was a hospital based retrospective study carried out in the
      Department of Medicine and Biochemistry of Manipal Teaching Hospital, Pokhara,
      Nepal between 1st January 2008 and 31st December 2011. The variables collected
      were SAA, CRP. Approval for the study was obtained from the institutional
      research ethical committee. Quantitative analysis of human SAA and C-reactive
      protein (CRP) was performed by radial immune diffusion (RID) assay for all cases.
      RESULTS: Of the 422 total cases of renal cell carcinoma, 218 patients had normal 
      and 204 abnormal SAA. SAA levels were grossly elevated in T3 stage
      (122.3+/-SD35.7) when compared to the mean for the T2 stage (84.2+/-SD24.4) (p
      value: 0.0001). Similarly, SAA levels were grossly elevated in M1 stage
      (190.0+/-SD12.7) when compared to the M0 stage (160.9+/-SD24.8) (p: 0.0001).
      There was no significant association with elevated CRP levels (209.1+/-SD22.7,
      normal 199.0+/-SD19.5) . CONCLUSION: The validity of SAA in serum as being of
      independent prognostic significance in RCC was demonstrated with higher levels in
      advanced stage disease.
FAU - Mittal, Ankush
AU  - Mittal A
AD  - Department of Biochemistry, Nepalese Army Institute of Health Sciences,
      Kathmandu, Nepal. drmittala@gmail.com
FAU - Poudel, Bibek
AU  - Poudel B
FAU - Pandeya, Dipendra Raj
AU  - Pandeya DR
FAU - Gupta, Satrudhan Pd
AU  - Gupta SP
FAU - Sathian, Brijesh
AU  - Sathian B
FAU - Yadav, Shambhu Kumar
AU  - Yadav SK
LA  - eng
PT  - Journal Article
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Serum Amyloid A Protein)
SB  - IM
MH  - Biomarkers, Tumor/*blood
MH  - Carcinoma, Renal Cell/*blood/diagnosis
MH  - Follow-Up Studies
MH  - Hospitals
MH  - Humans
MH  - Kidney Neoplasms/*blood/diagnosis
MH  - Neoplasm Grading
MH  - Neoplasm Staging
MH  - Nepal
MH  - Prognosis
MH  - Retrospective Studies
MH  - Serum Amyloid A Protein/*metabolism
EDAT- 2012/08/21 06:00
MHDA- 2013/01/23 06:00
CRDT- 2012/08/21 06:00
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2013/01/23 06:00 [medline]
AID - 10.7314/apjcp.2012.13.5.2253 [doi]
PST - ppublish
SO  - Asian Pac J Cancer Prev. 2012;13(5):2253-5. doi: 10.7314/apjcp.2012.13.5.2253.


PMID- 22901040
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20211021
IS  - 1179-2035 (Electronic)
IS  - 0112-1642 (Linking)
VI  - 42
IP  - 10
DP  - 2012 Oct 1
TI  - Carbohydrate supplementation and prolonged intermittent high-intensity exercise
      in adolescents: research findings, ethical issues and suggestions for the future.
PG  - 817-28
LID - 10.2165/11633030-000000000-00000 [doi]
AB  - In the last decade, research has begun to investigate the efficacy of
      carbohydrate supplementation for improving aspects of physical capacity and skill
      performance during sport-specific exercise in adolescent team games players. This
      research remains in its infancy, and further study would be beneficial
      considering the large youth population actively involved in team games.
      Literature on the influence of carbohydrate supplementation on skill performance 
      is scarce, limited to shooting accuracy in adolescent basketball players and
      conflicting in its findings. Between-study differences in the exercise protocol, 
      volume of fluid and carbohydrate consumed, use of prior fatiguing exercise and
      timing of skill tests may contribute to the different findings. Conversely,
      initial data supports carbohydrate supplementation in solution and gel form for
      improving intermittent endurance running capacity following soccer-specific
      shuttle running. These studies produced reliable data, but were subject to
      limitations including lack of quantification of the metabolic response of
      participants, limited generalization of data due to narrow participant age and
      maturation ranges, use of males and females within the same sample and
      non-standardized pre-exercise nutritional status between participants. There is a
      lack of consensus regarding the influence of frequently consuming
      carbohydrate-containing products on tooth enamel erosion and the development of
      obesity or being overweight in adolescent athletes and non-athletes. These
      discrepancies mean that the initiation or exacerbation of health issues due to
      frequent consumption of carbohydrate-containing products by adolescents cannot be
      conclusively refuted. Coupled with the knowledge that consuming a natural,
      high-carbohydrate diet -3-8 hours before exercise can significantly alter
      substrate use and improve exercise performance in adults, a moral and ethical
      concern is raised regarding the direction of future research in order to further 
      knowledge while safeguarding the health and well-being of young participants. It 
      could be deemed unethical to continue study into carbohydrate supplementation
      while ignoring the potential health concerns and the possibility of generating
      similar performance enhancements using natural dietary interventions. Therefore, 
      future work should investigate the influence of pre-exercise dietary intake on
      the prolonged intermittent, high-intensity exercise performance of adolescents.
      This would enable quantification of whether pre-exercise nutrition can modulate
      exercise performance and, if so, the optimum dietary composition to achieve this.
      Research could then combine this knowledge with ingestion of
      carbohydrate-containing products during exercise to facilitate ethical and
      healthy nutritional guidelines for enhancing the exercise performance of
      adolescents. This article addresses the available evidence regarding carbohydrate
      supplementation and prolonged intermittent, high-intensity exercise in adolescent
      team games players. It discusses the potential health concerns associated with
      the frequent use of carbohydrate-containing products by adolescents and how this 
      affects the research ethics of the field, and considers directions for future
      work.
FAU - Phillips, Shaun M
AU  - Phillips SM
AD  - Division of Sport and Exercise Sciences, University of Abertay Dundee, Dundee,
      Scotland. S.Phillips@abertay.ac.uk
LA  - eng
PT  - Journal Article
PL  - New Zealand
TA  - Sports Med
JT  - Sports medicine (Auckland, N.Z.)
JID - 8412297
RN  - 0 (Dietary Carbohydrates)
SB  - IM
MH  - Adolescent
MH  - Athletic Performance/physiology
MH  - Dietary Carbohydrates/*administration & dosage
MH  - *Dietary Supplements
MH  - Exercise/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Physical Endurance/physiology
MH  - Running/physiology
MH  - Soccer/physiology
MH  - Therapeutic Human Experimentation/ethics
EDAT- 2012/08/21 06:00
MHDA- 2013/02/13 06:00
CRDT- 2012/08/21 06:00
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
AID - 10.1007/BF03262296 [doi]
PST - ppublish
SO  - Sports Med. 2012 Oct 1;42(10):817-28. doi: 10.1007/BF03262296.


PMID- 22900965
OWN - NLM
STAT- MEDLINE
DCOM- 20130108
LR  - 20211021
IS  - 1471-2288 (Electronic)
IS  - 1471-2288 (Linking)
VI  - 12
DP  - 2012 Aug 17
TI  - Patient, caregiver, health professional and researcher views and experiences of
      participating in research at the end of life: a critical interpretive synthesis
      of the literature.
PG  - 123
LID - 10.1186/1471-2288-12-123 [doi]
AB  - BACKGROUND: The development of the evidence-base informing end of life (EoL) care
      is hampered by the assumption that patients at the EoL are too vulnerable to
      participate in research. This study aims to systematically and critically review 
      the evidence regarding the experiences and views of patients, caregivers,
      professionals and researchers about participation in EoL care research, and to
      identify best practices in research participation. METHODS: We searched seven
      electronic databases, and hand searched three journals and the bibliographies of 
      relevant papers. Inclusion criteria were original research papers on involvement 
      in EoL care research or its impact on participants. Critical interpretive
      synthesis was used to integrate the whole body of empirical evidence on this
      topic and generate theoretical categories from the evidence. RESULTS: Of a total 
      of 239 identified studies, 20 studies met the inclusion criteria, from: the US
      (11), the UK (6) and Australia (3). Most focused on patients with cancer (12) and
      were conducted in hospices (9) or hospitals (7). Studies enquired about issues
      related to: EoL care research in general (5), specific research methods (13), and
      trial research (2). The studies evaluating willingness to participate in EoL care
      research showed positive outcomes across the different parties involved in
      research. Factors influencing willingness were mainly physical and cognitive
      impairment. Participating in research was a positive experience for most patients
      and carers but a minority experienced distress. This was related to:
      characteristics of the participants; the type of research; or the way it was
      conducted. Participatory study designs were found particularly suitable for
      enabling the inclusion of a wide range of participants. CONCLUSION: The evidence 
      explored within this study demonstrates that the ethical concerns regarding
      patient participation in EoL care research are often unjustified. However,
      research studies in EoL care require careful design and execution that
      incorporates sensitivity to participants' needs and concerns to enable their
      participation. An innovative conceptual model for research participation relevant
      for potentially vulnerable people was developed.
FAU - Gysels, Marjolein H
AU  - Gysels MH
AD  - King's College London, Cicely Saunders Institute, Department of Palliative Care, 
      Policy & Rehabilitation School of Medicine, London, UK.
      marjolein.gysels@cresib.cat
FAU - Evans, Catherine
AU  - Evans C
FAU - Higginson, Irene J
AU  - Higginson IJ
LA  - eng
GR  - G0802654/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120817
PL  - England
TA  - BMC Med Res Methodol
JT  - BMC medical research methodology
JID - 100968545
SB  - IM
MH  - *Access to Information
MH  - Adult
MH  - Aged
MH  - Back Pain/*psychology/therapy
MH  - Female
MH  - *Health Services Accessibility
MH  - Health Status Indicators
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Rural Health/*standards
MH  - *Self Care
MH  - Socioeconomic Factors
MH  - Western Australia
PMC - PMC3489694
EDAT- 2012/08/21 06:00
MHDA- 2013/01/09 06:00
CRDT- 2012/08/21 06:00
PHST- 2011/09/14 00:00 [received]
PHST- 2012/05/28 00:00 [accepted]
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2013/01/09 06:00 [medline]
AID - 1471-2288-12-123 [pii]
AID - 10.1186/1471-2288-12-123 [doi]
PST - epublish
SO  - BMC Med Res Methodol. 2012 Aug 17;12:123. doi: 10.1186/1471-2288-12-123.


PMID- 22900558
OWN - NLM
STAT- MEDLINE
DCOM- 20130117
LR  - 20120820
IS  - 1745-8315 (Electronic)
IS  - 0020-7578 (Linking)
VI  - 93
IP  - 4
DP  - 2012 Aug
TI  - Informed consent as a prescription calling for debate between analysts and
      researchers.
PG  - 963-80
LID - 10.1111/j.1745-8315.2012.00615.x [doi]
AB  - This article is a review of the international scientific literature on informed
      consent and its use in some of the constituent organizations of the International
      Psychoanalytical Association (IPA). Because psychoanalysis comprises a theory
      based on practice, the dearth of clinical material for study, training and
      research purposes is a serious problem for analysts. Supervisions, presentations 
      at scientific societies and congresses, publications and teaching material
      involve patients to an extent that goes beyond the work done in their sessions.
      Should consent be requested in these cases? This contribution addresses
      controversial and long-standing issues such as informed consent and
      confidentiality, audio recording of treatments, knowledge production, the
      ambivalence of participating subjects over time and the perspective of analysts
      and patients respectively. The authors consider the various alternative
      approaches available for the handling of these ethical dilemmas without losing
      sight of the patient's dignity and personal rights, while also taking account of 
      the position of the analyst.
CI  - Copyright (c) 2012 Institute of Psychoanalysis.
FAU - Rodriguez Quiroga de Pereira, Andrea
AU  - Rodriguez Quiroga de Pereira A
AD  - Instituto Universitario de Salud Mental de la Asociacion Psicoanalitica de Buenos
      Aires (APdeBA). Departamento de Investigacion. amrqpereira@gmail.com
FAU - Messina, Veronica Maria
AU  - Messina VM
FAU - Sansalone, Paula Andrea
AU  - Sansalone PA
LA  - eng
PT  - Journal Article
DEP - 20120620
PL  - England
TA  - Int J Psychoanal
JT  - The International journal of psycho-analysis
JID - 2985179R
SB  - IM
MH  - *Cooperative Behavior
MH  - Ethics, Medical
MH  - Ethics, Research
MH  - Humans
MH  - *Informed Consent/ethics
MH  - *Interdisciplinary Communication
MH  - Mentors/education
MH  - Patient Advocacy
MH  - Physician-Patient Relations/ethics
MH  - *Psychoanalysis/education/ethics
MH  - Psychoanalytic Theory
MH  - *Research
EDAT- 2012/08/21 06:00
MHDA- 2013/01/18 06:00
CRDT- 2012/08/21 06:00
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2013/01/18 06:00 [medline]
AID - 10.1111/j.1745-8315.2012.00615.x [doi]
PST - ppublish
SO  - Int J Psychoanal. 2012 Aug;93(4):963-80. doi: 10.1111/j.1745-8315.2012.00615.x.
      Epub 2012 Jun 20.


PMID- 22900529
OWN - NLM
STAT- MEDLINE
DCOM- 20130424
LR  - 20121108
IS  - 1523-1739 (Electronic)
IS  - 0888-8892 (Linking)
VI  - 26
IP  - 6
DP  - 2012 Dec
TI  - Common and conflicting interests in the engagements between conservation
      organizations and corporations.
PG  - 967-77
LID - 10.1111/j.1523-1739.2012.01914.x [doi]
AB  - The conservation community increasingly views the corporate sector as a positive 
      force for conservation. Collaborations between corporations and nongovernmental
      conservation organizations (NGOs) seek to mitigate the negative effects of
      corporate activities and augment positive conservation outcomes. I reviewed the
      establishment of corporate social responsibility (CSR) policies by corporations; 
      the emerging focus on environmental practices and sustainability; and the history
      of engagement between corporations and nongovernmental organizations. I
      considered the ethical and reputation vulnerabilities of these collaborations,
      which depend especially on the financial nature of the relationship and reviewed 
      how CSR approaches have influenced corporate practices. I concluded that whereas 
      CSR practices can act to mitigate negative environmental impact, to date they
      have had limited positive effect on biodiversity conservation.
CI  - (c)2012 Society for Conservation Biology.
FAU - Robinson, John G
AU  - Robinson JG
AD  - Wildlife Conservation Society, 2300 Southern Boulevard, Bronx, NY 10471, USA.
      wildcons@gmail.com
LA  - eng
PT  - Journal Article
DEP - 20120817
PL  - United States
TA  - Conserv Biol
JT  - Conservation biology : the journal of the Society for Conservation Biology
JID - 9882301
SB  - IM
MH  - Biodiversity
MH  - *Conservation of Natural Resources
MH  - *Cooperative Behavior
MH  - *Organizations/economics/ethics
MH  - Private Sector/economics/ethics
MH  - *Professional Corporations/economics/ethics
MH  - *Social Responsibility
EDAT- 2012/08/21 06:00
MHDA- 2013/04/25 06:00
CRDT- 2012/08/21 06:00
PHST- 2011/08/18 00:00 [received]
PHST- 2012/05/09 00:00 [revised]
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2013/04/25 06:00 [medline]
AID - 10.1111/j.1523-1739.2012.01914.x [doi]
PST - ppublish
SO  - Conserv Biol. 2012 Dec;26(6):967-77. doi: 10.1111/j.1523-1739.2012.01914.x. Epub 
      2012 Aug 17.


PMID- 22900416
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20170203
IS  - 0723-1393 (Print)
IS  - 0723-1393 (Linking)
VI  - 31
IP  - 2
DP  - 2012 Jun
TI  - Latin American bioethics committees: tools for the prevention of medical and
      legal conflicts.
PG  - 325-34
AB  - Since Bioethics Committees in Latin America provide information and orientation
      in cases that lead to an ethical conflict or dilemma, they represent a very
      useful tool for physicians as well as for health service users, helping to avoid 
      or prevent conflicts between physicians and patients by choosing the best
      strategy to follow according to the patient, the physician and the particular
      situation.
FAU - Bostiancic, Maria Carla
AU  - Bostiancic MC
AD  - University of Mar del Plata Law School, Mar del Plata, Argentina.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Law
JT  - Medicine and law
JID - 8218185
SB  - IM
MH  - *Bioethical Issues
MH  - *Ethics Committees, Clinical
MH  - Humans
MH  - Latin America
EDAT- 2012/08/21 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/08/21 06:00
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
PST - ppublish
SO  - Med Law. 2012 Jun;31(2):325-34.


PMID- 22899597
OWN - NLM
STAT- MEDLINE
DCOM- 20140324
LR  - 20211021
IS  - 1460-2237 (Electronic)
IS  - 0268-1080 (Linking)
VI  - 28
IP  - 4
DP  - 2013 Jul
TI  - Interrogating scarcity: how to think about 'resource-scarce settings'.
PG  - 400-9
LID - 10.1093/heapol/czs071 [doi]
AB  - The idea of resource scarcity permeates health ethics and health policy analysis 
      in various contexts. However, health ethics inquiry seldom asks-as it should-why 
      some settings are 'resource-scarce' and others not. In this article I describe
      interrogating scarcity as a strategy for inquiry into questions of resource
      allocation within a single political jurisdiction and, in particular, as an
      approach to the issue of global health justice in an interconnected world. I
      demonstrate its relevance to the situation of low- and middle-income countries
      (LMICs) with brief descriptions of four elements of contemporary globalization:
      trade agreements; the worldwide financial marketplace and capital flight;
      structural adjustment; imperial geopolitics and foreign policy. This
      demonstration involves not only health care, but also social determinants of
      health. Finally, I argue that interrogating scarcity provides the basis for a
      new, critical approach to health policy at the interface of ethics and the social
      sciences, with specific reference to market fundamentalism as the value system
      underlying contemporary globalization.
FAU - Schrecker, Ted
AU  - Schrecker T
AD  - Bruye`re Research Institute and Department of Epidemiology and Community
      Medicine, University of Ottawa, Ottawa, Canada. tschrecker@sympatico.ca
LA  - eng
GR  - 79153/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120816
PL  - England
TA  - Health Policy Plan
JT  - Health policy and planning
JID - 8610614
MH  - Delivery of Health Care/ethics
MH  - Developing Countries/economics
MH  - Health Policy
MH  - Health Resources/*supply & distribution
MH  - Policy Making
MH  - Social Justice
PMC - PMC3697203
OTO - NOTNLM
OT  - Resource allocation
OT  - globalization
OT  - health ethics
OT  - justice
OT  - scarcity
EDAT- 2012/08/18 06:00
MHDA- 2014/03/25 06:00
CRDT- 2012/08/18 06:00
PHST- 2012/08/18 06:00 [entrez]
PHST- 2012/08/18 06:00 [pubmed]
PHST- 2014/03/25 06:00 [medline]
AID - czs071 [pii]
AID - 10.1093/heapol/czs071 [doi]
PST - ppublish
SO  - Health Policy Plan. 2013 Jul;28(4):400-9. doi: 10.1093/heapol/czs071. Epub 2012
      Aug 16.


PMID- 22899582
OWN - NLM
STAT- MEDLINE
DCOM- 20131126
LR  - 20220408
IS  - 1592-8721 (Electronic)
IS  - 0390-6078 (Linking)
VI  - 98
IP  - 3
DP  - 2013 Mar
TI  - A phase II study of lenalidomide in patients with extranodal marginal zone B-cell
      lymphoma of the mucosa associated lymphoid tissue (MALT lymphoma).
PG  - 353-6
LID - 10.3324/haematol.2012.065995 [doi]
AB  - Mucosa associated lymphoid tissue lymphoma shares certain features with multiple 
      myeloma. In view of this and the activity of lenalidomide in various B-cell
      lymphomas, we have initiated a phase II study of lenalidomide in patients with
      mucosa associated lymphoid tissue lymphoma. Patients with histologically verified
      advanced stages of this lymphoma were included in the study. Treatment consisted 
      of oral lenalidomide 25 mg Days 1-21, with a 7-day break after each cycle. A
      total of 18 patients were included in the trial: 5 had gastric and 13 had
      extragastric mucosa associated lymphoid tissue lymphoma, but 2 discontinued
      therapy during the first course of therapy. In the intent to treat analysis, an
      overall response rate of 61% was seen (11 of 18; 6 complete and 5 partial
      remissions). Three patients had stable disease while 2 progressed. Side effects
      were manageable and included neutropenia (grade III in 3 patients) as the leading
      hematotoxicity. After a median follow up of 20.3 months, one patient has died
      from lymphoma while the remaining patients are alive and relapse-free. These data
      suggest activity of lenalidomide monotherapy in mucosa associated lymphoid tissue
      lymphoma. The study protocol had been approved by the Ethical Board of the
      Medical University Vienna (EK-No.: 146/09), and before opening the trial, it had 
      been registered at www.clinicaltrials.gov. (identifier: NCT00923663).
FAU - Kiesewetter, Barbara
AU  - Kiesewetter B
AD  - Clinical Division of Oncology, Department of Internal Medicine I, University
      Vienna, Vienna, Austria.
FAU - Troch, Marlene
AU  - Troch M
FAU - Dolak, Werner
AU  - Dolak W
FAU - Mullauer, Leonhard
AU  - Mullauer L
FAU - Lukas, Julius
AU  - Lukas J
FAU - Zielinski, Christoph C
AU  - Zielinski CC
FAU - Raderer, Markus
AU  - Raderer M
LA  - eng
SI  - ClinicalTrials.gov/NCT00923663
PT  - Clinical Trial, Phase II
PT  - Journal Article
DEP - 20120816
PL  - Italy
TA  - Haematologica
JT  - Haematologica
JID - 0417435
RN  - 0 (Antineoplastic Agents)
RN  - 4Z8R6ORS6L (Thalidomide)
RN  - F0P408N6V4 (Lenalidomide)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antineoplastic Agents/adverse effects/*therapeutic use
MH  - Female
MH  - Humans
MH  - Lenalidomide
MH  - Lymphoma, B-Cell, Marginal Zone/*drug therapy/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Thalidomide/adverse effects/*analogs & derivatives/therapeutic use
MH  - Treatment Outcome
PMC - PMC3659944
EDAT- 2012/08/18 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/08/18 06:00
PHST- 2012/08/18 06:00 [entrez]
PHST- 2012/08/18 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - haematol.2012.065995 [pii]
AID - 10.3324/haematol.2012.065995 [doi]
PST - ppublish
SO  - Haematologica. 2013 Mar;98(3):353-6. doi: 10.3324/haematol.2012.065995. Epub 2012
      Aug 16.


PMID- 22899412
OWN - NLM
STAT- MEDLINE
DCOM- 20121231
LR  - 20120817
IS  - 1512-0112 (Print)
IS  - 1512-0112 (Linking)
IP  - 208-209
DP  - 2012 Jul
TI  - Inflammatory markers of gallstones disease in menopausal women.
PG  - 52-5
AB  - Among the factors contributing to the gallstones formation an important role
      belongs to the inflammation. The goal of our research - determination alterations
      of the redox balance and cytokines (IL-1alpha, IL-6, IL-8, TNF-alpha) content in 
      the blood postmenopausal women with gallstone disease. 58 menopausal women with
      gallstone disease, who had been admitted to the LTD "1-st Clinic" (Tbilisi,
      Georgia) during 2009-2011 were studied. Gallstone disease was proved by
      Ultrasonography method. The control group consisted of 25 menopause aged women
      without gallstone disease. The Local Ethics Committee approved the protocol, and 
      informed consent was obtained from all participants or their surrogates. Patients
      was conducted for blood redox status (EPR signals of superoxide (O2-) and
      lipoperoxide (LOO.) radicals) and citokins (IL-1alpha, IL-6, IL-8, TNF-alpha)
      content. It was revealed increase production of oxygen and lipoperoxide free
      radicals, macrophage inflammatory cytokines (IL-6, IL-1alpha, TNF-alpha) in blood
      of menopausal women with gallstone disease. It was concluded that macrophages
      play a dominant role in the inflammatory and oxidative response during
      gallbladder stones disease in postmenopausal women.
FAU - Shengelia, M
AU  - Shengelia M
AD  - Tbilisi State Medical University, Georgia.
FAU - Intskirveli, N
AU  - Intskirveli N
FAU - Gogebashvili, N
AU  - Gogebashvili N
LA  - eng
PT  - Journal Article
PL  - Georgia (Republic)
TA  - Georgian Med News
JT  - Georgian medical news
JID - 101218222
RN  - 0 (Interleukin-1alpha)
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukin-8)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Gallstones/*blood/complications
MH  - Humans
MH  - *Inflammation/blood/complications
MH  - Interleukin-1alpha/blood
MH  - Interleukin-6/blood
MH  - Interleukin-8/blood
MH  - Lipid Peroxidation
MH  - Macrophages/metabolism
MH  - *Oxidative Stress
MH  - Tumor Necrosis Factor-alpha/blood
EDAT- 2012/08/18 06:00
MHDA- 2013/01/01 06:00
CRDT- 2012/08/18 06:00
PHST- 2012/08/18 06:00 [entrez]
PHST- 2012/08/18 06:00 [pubmed]
PHST- 2013/01/01 06:00 [medline]
PST - ppublish
SO  - Georgian Med News. 2012 Jul;(208-209):52-5.


PMID- 22899411
OWN - NLM
STAT- MEDLINE
DCOM- 20121231
LR  - 20171116
IS  - 1512-0112 (Print)
IS  - 1512-0112 (Linking)
IP  - 208-209
DP  - 2012 Jul
TI  - Some aspects of pathogenesis of nonalcoholic fatty liver disease in
      postmenopausal women.
PG  - 46-51
AB  - In view of the reversibility of steatosis and steatohepatitis, their early
      diagnosis is one of the most significant problems of modern medicine. The aim of 
      the study was the establishment futures of the pathogenesis of NAFLD in
      postmenopausal women. The study was conducted on postmenopausal women (n=5), with
      metabolic syndrome and rate of ALT in the blood at least 4 times greater than its
      normal maximal value. Patients had to fulfill the following inclusion criteria:
      at least 12 month of amenorrhea. Verification of the diagnosis of NAFLD was based
      on abdominal ultrosonografic examination. In addition to collecting history,
      study of blood lipid profile and ALT, AST, estrogen content in patients enrolled 
      in the study free nitric oxide content in the blood and liver bioptants was
      determined by Electron Paramagnetic Resonance (EPR) method. The study protocol
      approved by the Ethics Committee of the Tbilisi State Medical University.
      Patients by written form confirmed their agreement to participate in the study.
      In patients with NAFLD levels of total cholesterol, LDL-cholesterol and
      triglycerides were generally increased in the blood serum, direct correlation
      revealed between level of NO EPR signal intensity in liver bioptat and
      triglycerides content in blood (r=0,96; p=0,009). It was concluded that
      estrogen-dependent factors, such as impaired lipid metabolism and increase
      expression of iNOS induce accumulation of triglycerides and free fatty acids in
      the liver, generation excess amounts of NO, which in oxidative stress reveal
      their cytotoxity and promote progression of NAFLD in postmenopausal women.
FAU - Parkosadze, G
AU  - Parkosadze G
AD  - Tbilisi State Medical University, Georgia.
FAU - Sulakvelidze, M
AU  - Sulakvelidze M
FAU - Mizandari, M
AU  - Mizandari M
FAU - Ratiani, L
AU  - Ratiani L
FAU - Sanikidze, T
AU  - Sanikidze T
LA  - eng
PT  - Journal Article
PL  - Georgia (Republic)
TA  - Georgian Med News
JT  - Georgian medical news
JID - 101218222
RN  - 0 (Lipids)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - EC 2.6.1.2 (Alanine Transaminase)
SB  - IM
MH  - Alanine Transaminase/blood
MH  - Aspartate Aminotransferases/blood
MH  - *Fatty Liver/blood/complications/pathology
MH  - Female
MH  - Humans
MH  - Lipids/blood
MH  - Liver/metabolism
MH  - *Metabolic Syndrome/blood/complications/pathology
MH  - Middle Aged
MH  - Nitric Oxide Synthase/blood/metabolism
MH  - Non-alcoholic Fatty Liver Disease
MH  - Oxidative Stress
MH  - Postmenopause
MH  - Risk Factors
EDAT- 2012/08/18 06:00
MHDA- 2013/01/01 06:00
CRDT- 2012/08/18 06:00
PHST- 2012/08/18 06:00 [entrez]
PHST- 2012/08/18 06:00 [pubmed]
PHST- 2013/01/01 06:00 [medline]
PST - ppublish
SO  - Georgian Med News. 2012 Jul;(208-209):46-51.


PMID- 22899092
OWN - NLM
STAT- MEDLINE
DCOM- 20130722
LR  - 20220210
IS  - 1530-0366 (Electronic)
IS  - 1098-3600 (Linking)
VI  - 15
IP  - 2
DP  - 2013 Feb
TI  - Avoiding genetic genocide: understanding good intentions and eugenics in the
      complex dialogue between the medical and disability communities.
PG  - 95-102
LID - 10.1038/gim.2012.102 [doi]
AB  - The relationship between the medical and disability communities is complex and is
      influenced by historical, social, and cultural factors. Although clinicians,
      health-care researchers, and people with disabilities all work from the
      standpoint of the best interest of disabled individuals, the notion of what
      actually is "best" is often understood quite differently among these
      constituencies. Eugenics campaigns, legal restrictions on reproductive and other 
      freedoms, and prenatal testing recommendations predicated on the lesser worth of 
      persons with disabilities have all contributed toward the historic trauma
      experienced by the disability community, particularly with respect to medical
      genetics. One premise of personalized medicine is that different individuals
      require different solutions. Disabled persons' experiences are a reminder that
      these solutions can be best realized by maintaining awareness and sensitivity in 
      a complex ethical and moral terrain. Geneticists should recognize that their
      research may have implications for those with disabilities; they should recognize
      the impact of the historical trauma of the eugenics movement, and seek to involve
      people with disabilities in discussions about policies that affect them. Dialogue
      can be messy and uncomfortable, but it is the only way to avoid the mistakes of
      the past and to ensure a more equitable, and healthful, future.
FAU - Miller, Paul Steven
AU  - Miller PS
AD  - University of Washington School of Law, Seattle, WA, USA.
FAU - Levine, Rebecca Leah
AU  - Levine RL
LA  - eng
GR  - P50 HG003374/HG/NHGRI NIH HHS/United States
GR  - P50 HG 3374/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120816
PL  - United States
TA  - Genet Med
JT  - Genetics in medicine : official journal of the American College of Medical
      Genetics
JID - 9815831
SB  - IM
MH  - *Disabled Persons
MH  - *Eugenics
MH  - Genetics, Medical/*ethics
MH  - Genocide/*prevention & control
MH  - Humans
MH  - Intention
MH  - Morals
PMC - PMC3566260
MID - NIHMS432796
EDAT- 2012/08/18 06:00
MHDA- 2013/07/23 06:00
CRDT- 2012/08/18 06:00
PHST- 2012/08/18 06:00 [entrez]
PHST- 2012/08/18 06:00 [pubmed]
PHST- 2013/07/23 06:00 [medline]
AID - S1098-3600(21)00905-9 [pii]
AID - 10.1038/gim.2012.102 [doi]
PST - ppublish
SO  - Genet Med. 2013 Feb;15(2):95-102. doi: 10.1038/gim.2012.102. Epub 2012 Aug 16.


PMID- 22898736
OWN - NLM
STAT- MEDLINE
DCOM- 20121026
LR  - 20220310
IS  - 1474-4465 (Electronic)
IS  - 1474-4422 (Linking)
VI  - 11
IP  - 9
DP  - 2012 Sep
TI  - Clinical trials for therapeutic assessment of antiepileptic drugs in the 21st
      century: obstacles and solutions.
PG  - 827-34
LID - 10.1016/S1474-4422(12)70177-1 [doi]
AB  - Clinical trials as part of antiepileptic drug development are increasingly
      expensive and complex, with many pitfalls that can derail even promising drugs
      and devices. Although a third of patients remain resistant to treatment, the
      availability of more than 20 approved antiepileptic drugs can reduce the
      incentive to enrol in trials of unproven agents, for which safety is not assured.
      The challenge of recruiting patients drives investigators to regions of the world
      where treatment options are more limited. This increases complexity and has
      potential implications for quality of the trial data. Furthermore, the
      availability of so many approved treatments raises questions about the ethics and
      safety of placebo-controlled trials in patients with epilepsy. Novel trial
      designs, such as time-to-event adjunctive therapy and historical-control
      monotherapy, might be more acceptable to patients and their doctors because they 
      restrict exposure to placebo or ineffective treatments.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Friedman, Daniel
AU  - Friedman D
AD  - NYU Comprehensive Epilepsy Center, Department of Neurology, New York University, 
      New York, NY 10016, USA.
FAU - French, Jacqueline A
AU  - French JA
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - Lancet Neurol
JT  - The Lancet. Neurology
JID - 101139309
RN  - 0 (Anticonvulsants)
SB  - IM
MH  - Anticonvulsants/*therapeutic use
MH  - Clinical Trials as Topic/*methods/*trends
MH  - Epilepsy/*drug therapy
MH  - Humans
MH  - *Outcome Assessment, Health Care
EDAT- 2012/08/18 06:00
MHDA- 2012/10/27 06:00
CRDT- 2012/08/18 06:00
PHST- 2012/08/18 06:00 [entrez]
PHST- 2012/08/18 06:00 [pubmed]
PHST- 2012/10/27 06:00 [medline]
AID - S1474-4422(12)70177-1 [pii]
AID - 10.1016/S1474-4422(12)70177-1 [doi]
PST - ppublish
SO  - Lancet Neurol. 2012 Sep;11(9):827-34. doi: 10.1016/S1474-4422(12)70177-1.


PMID- 22898700
OWN - NLM
STAT- MEDLINE
DCOM- 20130717
LR  - 20130125
IS  - 1873-5894 (Electronic)
IS  - 0730-725X (Linking)
VI  - 31
IP  - 2
DP  - 2013 Feb
TI  - Assessment of normal flow patterns in the pulmonary circulation by using 4D
      magnetic resonance velocity mapping.
PG  - 178-88
LID - 10.1016/j.mri.2012.06.036 [doi]
LID - S0730-725X(12)00246-9 [pii]
AB  - OBJECTIVE: The purpose of this study was to analyze flow patterns in the
      pulmonary circulation of healthy volunteers by using 4D flow magnetic resonance
      imaging. MATERIALS AND METHODS: The study was approved by the local ethics
      committee and all subjects gave written informed consent. Eighteen volunteers
      underwent a 4D flow scan of the whole-heart. Two patients with congenital heart
      disease were also included to detect possible patterns of flow abnormalities
      (Patient 1: corrected transposition of great arteries (TGA); Patient 2: partial
      anomalous pulmonary venous return and atrial septal defect). To analyze flow
      patterns, 2D planes were placed on the main pulmonary artery (PA), left and right
      PA. Flow patterns were assessed manually by two independent viewers using vector 
      fields, streamlines and particle traces, and semi-automatically by vorticity
      quantification. RESULTS: Two counter-rotating helices were found in the main PA
      of volunteers. Right-handed helical flow was detected in the right PA of 15
      volunteers. Analysis of the helical flow by particles traces revealed that both
      helices contributed mainly to the flow in the right PA. In the patient with
      corrected TGA helical flow was not detected. Abnormal vortical flow was
      visualized in the main PA of patient 2, suggesting elevated mean PA pressure.
      CONCLUSIONS: Helical flow is normally present in the main PA and right PA. 4D
      flow is an excellent tool to evaluate noninvasively complex blood flow patterns
      in the pulmonary circulation. Knowledge of normal and abnormal flow patterns
      might help to evaluate patients with congenital heart disease adding functional
      information undetectable with other imaging modalities.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Bachler, Pablo
AU  - Bachler P
AD  - Biomedical Imaging Center, Pontificia Universidad Catolica de Chile, Santiago,
      Chile.
FAU - Pinochet, Natalia
AU  - Pinochet N
FAU - Sotelo, Julio
AU  - Sotelo J
FAU - Crelier, Gerard
AU  - Crelier G
FAU - Irarrazaval, Pablo
AU  - Irarrazaval P
FAU - Tejos, Cristian
AU  - Tejos C
FAU - Uribe, Sergio
AU  - Uribe S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120813
PL  - Netherlands
TA  - Magn Reson Imaging
JT  - Magnetic resonance imaging
JID - 8214883
SB  - IM
MH  - Adult
MH  - Automation
MH  - Blood Flow Velocity
MH  - Female
MH  - Heart Rate
MH  - Hemodynamics
MH  - Humans
MH  - Lung/*blood supply
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Pulmonary Artery/pathology
MH  - Pulmonary Circulation/*physiology
EDAT- 2012/08/18 06:00
MHDA- 2013/07/19 06:00
CRDT- 2012/08/18 06:00
PHST- 2012/02/17 00:00 [received]
PHST- 2012/06/09 00:00 [revised]
PHST- 2012/06/28 00:00 [accepted]
PHST- 2012/08/18 06:00 [entrez]
PHST- 2012/08/18 06:00 [pubmed]
PHST- 2013/07/19 06:00 [medline]
AID - S0730-725X(12)00246-9 [pii]
AID - 10.1016/j.mri.2012.06.036 [doi]
PST - ppublish
SO  - Magn Reson Imaging. 2013 Feb;31(2):178-88. doi: 10.1016/j.mri.2012.06.036. Epub
      2012 Aug 13.


PMID- 22898686
OWN - NLM
STAT- MEDLINE
DCOM- 20130424
LR  - 20151119
IS  - 1873-5894 (Electronic)
IS  - 0730-725X (Linking)
VI  - 30
IP  - 10
DP  - 2012 Dec
TI  - Detection of colorectal metastases in patients being treated with chemotherapy
      utilising SPIO-MRI: a radiological-pathological study.
PG  - 1446-53
LID - 10.1016/j.mri.2012.04.016 [doi]
LID - S0730-725X(12)00193-2 [pii]
AB  - OBJECTIVE: Chemotherapy commonly causes liver injury through sinusoidal
      obstructive syndrome and steatosis. Chemotherapy-induced liver injury may make it
      more difficult to detect metastases secondary to reduced contrast between the
      injured liver and metastases. The aim of this study was to determine the
      sensitivity of superparamagnetic iron oxide (SPIO) contrast-enhanced imaging in
      patients who have undergone chemotherapy prior to liver surgery. METHODS: Local
      ethics committee approval was obtained. Thirty-one patients with hepatic
      metastases completing preoperative chemotherapy were prospectively recruited.
      Images were reviewed independently by two blinded observers who identified and
      localized lesions with a four-point confidence scale. The alternative
      free-response receiver operator characteristic method was used to analyze the
      results. RESULTS: The sensitivity in detecting colorectal metastases following
      chemotherapy was 78% and 76%, respectively, for observers 1 and 2 (95% confidence
      interval: 71%-85% and 68%-82%). The areas under the alternative free-response
      receiver operator curves were 0.73 and 0.80 for observers 1 and 2, respectively. 
      CONCLUSION: Compared to previously published work on chemotherapy-naive patients,
      it is clear that the sensitivity of SPIO-enhanced magnetic resonance imaging
      (MRI) in detecting colorectal metastases following chemotherapy is reduced. It is
      therefore critical that all imaging--pre-, during and postchemotherapy--is
      reviewed when reporting liver MRI prior to surgery.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Smith, Jonathan T
AU  - Smith JT
AD  - Leeds Teaching Hospitals NHS Trust, St James's Institute of Oncology, Radiology
      Department, Bexley Wing, LS9 7TF Leeds, UK. jonathan.smith@leedsth.nhs.uk
FAU - Ward, Janice
AU  - Ward J
FAU - Guthrie, James A
AU  - Guthrie JA
FAU - Sheridan, Maria B
AU  - Sheridan MB
FAU - Boyes, Sheila
AU  - Boyes S
FAU - Wilson, Daniel
AU  - Wilson D
FAU - Wyatt, Judy I
AU  - Wyatt JI
FAU - Treanor, Darren
AU  - Treanor D
FAU - Robinson, Philip J
AU  - Robinson PJ
LA  - eng
PT  - Journal Article
DEP - 20120813
PL  - Netherlands
TA  - Magn Reson Imaging
JT  - Magnetic resonance imaging
JID - 8214883
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Contrast Media)
RN  - 0 (Ferric Compounds)
RN  - 1K09F3G675 (ferric oxide)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antineoplastic Agents/pharmacology/*therapeutic use
MH  - Colorectal Neoplasms/*diagnosis/*drug therapy/*pathology
MH  - Contrast Media/pharmacology
MH  - False Positive Reactions
MH  - Female
MH  - Ferric Compounds/chemistry
MH  - Humans
MH  - Liver/injuries/pathology
MH  - Liver Neoplasms/*diagnosis/*drug therapy/*pathology
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Metastasis
MH  - Observer Variation
MH  - ROC Curve
MH  - Reproducibility of Results
EDAT- 2012/08/18 06:00
MHDA- 2013/04/25 06:00
CRDT- 2012/08/18 06:00
PHST- 2011/11/16 00:00 [received]
PHST- 2012/04/03 00:00 [revised]
PHST- 2012/04/18 00:00 [accepted]
PHST- 2012/08/18 06:00 [entrez]
PHST- 2012/08/18 06:00 [pubmed]
PHST- 2013/04/25 06:00 [medline]
AID - S0730-725X(12)00193-2 [pii]
AID - 10.1016/j.mri.2012.04.016 [doi]
PST - ppublish
SO  - Magn Reson Imaging. 2012 Dec;30(10):1446-53. doi: 10.1016/j.mri.2012.04.016. Epub
      2012 Aug 13.


PMID- 22898336
OWN - NLM
STAT- MEDLINE
DCOM- 20130620
LR  - 20220309
IS  - 1471-2288 (Electronic)
IS  - 1471-2288 (Linking)
VI  - 12
DP  - 2012 Aug 16
TI  - Bureaucracy stifles medical research in Britain: a tale of three trials.
PG  - 122
LID - 10.1186/1471-2288-12-122 [doi]
AB  - BACKGROUND: Recent developments aiming to standardise and streamline processes of
      gaining the necessary approvals to carry out research in the National Health
      Service (NHS) in the United Kingdom (UK), have resulted in lengthy and costly
      delays. The national UK governmental Department of Health's Research Governance
      Framework (RGF) for Health and Social Care requires that appropriate checks be
      conducted before research involving human participants, their organs, tissues or 
      data can commence in the NHS. As a result, medical research has been subjected to
      increased regulation and governance, with the requirement for approvals from
      numerous regulatory and monitoring bodies. In addition, the processes and
      outcomes of the attribution of costs in NHS research have caused additional
      difficulties for researchers. The purpose of this paper is to illustrate, through
      three trial case studies, the difficulties encountered during the set-up and
      recruitment phases of these trials, related to gaining the necessary ethical and 
      governance approvals and applying for NHS costs to undertake and deliver the
      research. METHODS: Empirical evidence about delays and difficulties related to
      regulation and governance of medical research was gathered during the period
      2009-2010 from three UK randomised controlled trials with sites in England, Wales
      and Scotland (1. SAFER 2- an emergency care based trial of a protocol for
      paramedics to refer patients directly to community based falls services; 2.
      COnStRUCT- a trial of two drugs for acute ulcerative colitis; and 3. Family Links
      - a trial of a public health intervention, a 10 week community based parenting
      programme). Findings and recommendations were reported in response to a call for 
      evidence from The Academy of Medical Sciences regarding difficulties encountered 
      in conducting medical research arising from R&D governance and regulation, to
      inform national policy. RESULTS: Difficulties and delays in navigating and
      gaining the appropriate approvals and NHS costs required to undertake the
      research were encountered in all three trials, at various points in the
      bureaucratic processes of ethical and research and information governance
      approvals. Conduct of each of the three trials was delayed by at least 12 months,
      with costs increasing by 30 - 40%. CONCLUSIONS: Whilst the three trials
      encountered a variety of challenges, there were common issues. The processes for 
      gaining approvals were overly complex and differed between sites and UK
      countries; guidance about processes was unclear; and information regarding how to
      define and claim NHS costs for undertaking the research was inconsistent. The
      competitive advantage of a publicly funded, open access health system for
      undertaking health services research and clinical trials within the UK has been
      outweighed in recent years by stifling bureaucratic structures and processes for 
      governance of research. The recommendations of the Academy of Medical Sciences
      are welcomed, and the effects of their implementation are awaited with interest. 
      TRIAL REGISTRATION NUMBERS: SAFER 2: ISRCTN 60481756; COnStRUCT: ISRCTN22663589; 
      Family Links: ISRCTN 13929732.
FAU - Snooks, Helen
AU  - Snooks H
AD  - College of Medicine, Swansea University, Singleton Park, Swansea, SA2 8PP, UK.
      h.a.snooks@swansea.ac.uk
FAU - Hutchings, Hayley
AU  - Hutchings H
FAU - Seagrove, Anne
AU  - Seagrove A
FAU - Stewart-Brown, Sarah
AU  - Stewart-Brown S
FAU - Williams, John
AU  - Williams J
FAU - Russell, Ian
AU  - Russell I
LA  - eng
SI  - ISRCTN/ISRCTN13929732
SI  - ISRCTN/ISRCTN22663589
SI  - ISRCTN/ISRCTN60481756
PT  - Journal Article
DEP - 20120816
PL  - England
TA  - BMC Med Res Methodol
JT  - BMC medical research methodology
JID - 100968545
SB  - IM
MH  - Biomedical Research/ethics/standards
MH  - *Drug Approval
MH  - Government Agencies
MH  - Humans
MH  - *Randomized Controlled Trials as Topic
MH  - State Medicine
MH  - United Kingdom
PMC - PMC3537588
EDAT- 2012/08/18 06:00
MHDA- 2013/06/21 06:00
CRDT- 2012/08/18 06:00
PHST- 2012/02/13 00:00 [received]
PHST- 2012/08/03 00:00 [accepted]
PHST- 2012/08/18 06:00 [entrez]
PHST- 2012/08/18 06:00 [pubmed]
PHST- 2013/06/21 06:00 [medline]
AID - 1471-2288-12-122 [pii]
AID - 10.1186/1471-2288-12-122 [doi]
PST - epublish
SO  - BMC Med Res Methodol. 2012 Aug 16;12:122. doi: 10.1186/1471-2288-12-122.


PMID- 22897812
OWN - NLM
STAT- MEDLINE
DCOM- 20151029
LR  - 20151119
IS  - 1478-5153 (Electronic)
IS  - 1362-1017 (Linking)
VI  - 17
IP  - 5
DP  - 2012 Sep-Oct
TI  - Development of an instrument to determine competencies of postgraduate ICU nurses
      in Cyprus.
PG  - 255-64
LID - 10.1111/j.1478-5153.2012.00503.x [doi]
AB  - AIMS AND OBJECTIVES: The study sought to explore the expected competencies for
      postgraduate intensive care unit nurses aiming to develop a future
      competency-based curriculum. The aim of this part of the study is to develop a
      new instrument to determine what competencies are expected of postgraduate
      critical care nurses. BACKGROUND: Despite existing competency frameworks that
      emerged from research in the area of critical care, globally and within countries
      there is diversity and an ongoing debate regarding level of critical care
      education, outcomes and competencies acquired. DESIGN AND METHODS: A combination 
      of qualitative and quantitative approach was used. In first stage (qualitative), 
      focus groups and interviews were used aiming to explore critical care nurses
      views concerning expected competencies of postgraduate critical care nurses. In
      second stage (quantitative), an 81 items Likert scale questionnaire, which was
      designed based on qualitative data and literature, was distributed among critical
      care nurses in Cyprus (n: 234, response rate 66%) aiming to receive feedback from
      clinical nurses and validate the instrument. Psychometric approaches such as
      internal consistency reliability using Cronbach's alpha and construct validity
      were used to validate the instrument. RESULTS: The final questionnaire includes
      72 items and has a four-dimensional structure. The four dimensions are (1)
      leadership/management and professional development, (2) decision-making and
      management of emergencies, (3) provision of care and professional practice and
      (4) ethical practice. All factors were highly reliable, with Cronbach's alpha
      ranging from 0.895 to 0.974. CONCLUSIONS: A new instrument to determine what
      competencies are expected of postgraduate critical care nurses was generated from
      this study. A new framework of competencies is grounded on this study that
      addresses the holistic, individualized and ethically informed quality care of
      critically ill and may inform educational strategies. RELEVANCE TO CLINICAL
      PRACTICE: Critical care nurses competencies need to be determined for quality
      care and speciality development.
CI  - (c) 2012 The Authors. Nursing in Critical Care (c) 2012 British Association of
      Critical Care Nurses.
FAU - Hadjibalassi, Maria
AU  - Hadjibalassi M
AD  - Department of Nursing, School of Health Sciences, Cyprus University of
      Technology, 11 Gregory Afxentiou Street, Paliometocho, Nicosia, Cyprus.
      maria.hadjibalassi@cut.ac.cy
FAU - Papastavrou, Evridiki
AU  - Papastavrou E
FAU - Lambrinou, Ekaterini
AU  - Lambrinou E
FAU - Tsangari, Haritini
AU  - Tsangari H
FAU - Athini, Evdokia
AU  - Athini E
FAU - Georgiou, Evanthia
AU  - Georgiou E
FAU - Nicolaou, Elisavet
AU  - Nicolaou E
FAU - Merkouris, Anastasios
AU  - Merkouris A
LA  - eng
PT  - Journal Article
DEP - 20120326
PL  - England
TA  - Nurs Crit Care
JT  - Nursing in critical care
JID - 9808649
MH  - Adult
MH  - *Clinical Competence
MH  - *Critical Care Nursing
MH  - Cyprus
MH  - Decision Making
MH  - Ethics, Nursing
MH  - Female
MH  - Focus Groups
MH  - Humans
MH  - Intensive Care Units
MH  - Interviews as Topic
MH  - Leadership
MH  - Male
MH  - Middle Aged
MH  - Psychometrics
MH  - Reproducibility of Results
MH  - Surveys and Questionnaires
EDAT- 2012/08/18 06:00
MHDA- 2015/10/30 06:00
CRDT- 2012/08/18 06:00
PHST- 2012/08/18 06:00 [entrez]
PHST- 2012/08/18 06:00 [pubmed]
PHST- 2015/10/30 06:00 [medline]
AID - 10.1111/j.1478-5153.2012.00503.x [doi]
PST - ppublish
SO  - Nurs Crit Care. 2012 Sep-Oct;17(5):255-64. doi: 10.1111/j.1478-5153.2012.00503.x.
      Epub 2012 Mar 26.


PMID- 22897013
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20190724
IS  - 0021-5384 (Print)
IS  - 0021-5384 (Linking)
VI  - 101
IP  - 7
DP  - 2012 Jul 10
TI  - [The cutting-edge of medicine: Approaching ethical issues in clinical settings].
PG  - 2059-64
FAU - Fujita, Misao
AU  - Fujita M
AD  - Department of Biomedical Ethics, The University of Tokyo, Graduate School of
      Medicine, Japan.
FAU - Akabayashi, Akira
AU  - Akabayashi A
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Nihon Naika Gakkai Zasshi
JT  - Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal
      Medicine
JID - 19130210R
SB  - IM
MH  - *Ethics Committees, Clinical
MH  - *Ethics Consultation
MH  - *Ethics, Clinical
MH  - Hospitals, General/organization & administration
MH  - Humans
MH  - Japan
EDAT- 2012/08/18 06:00
MHDA- 2012/11/14 06:00
CRDT- 2012/08/18 06:00
PHST- 2012/08/18 06:00 [entrez]
PHST- 2012/08/18 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
AID - 10.2169/naika.101.2059 [doi]
PST - ppublish
SO  - Nihon Naika Gakkai Zasshi. 2012 Jul 10;101(7):2059-64. doi:
      10.2169/naika.101.2059.


PMID- 22896988
OWN - NLM
STAT- MEDLINE
DCOM- 20121003
LR  - 20120817
IS  - 0023-2149 (Print)
IS  - 0023-2149 (Linking)
VI  - 90
IP  - 4
DP  - 2012
TI  - [Professional and ethical views of the physician humanist F.P.Gaaz].
PG  - 73-7
FAU - Blokhina, N N
AU  - Blokhina NN
LA  - rus
PT  - Biography
PT  - Historical Article
PT  - Journal Article
PL  - Russia (Federation)
TA  - Klin Med (Mosk)
JT  - Klinicheskaia meditsina
JID - 2985204R
SB  - IM
MH  - Ethics, Clinical/*history
MH  - History, 18th Century
MH  - History, 19th Century
MH  - *Humanism
MH  - Humans
MH  - Physician's Role/*history
PS  - Haas FJ
FPS - Haas, Friedrich Joseph
EDAT- 2012/08/18 06:00
MHDA- 2012/10/04 06:00
CRDT- 2012/08/18 06:00
PHST- 2012/08/18 06:00 [entrez]
PHST- 2012/08/18 06:00 [pubmed]
PHST- 2012/10/04 06:00 [medline]
PST - ppublish
SO  - Klin Med (Mosk). 2012;90(4):73-7.


PMID- 22896967
OWN - NLM
STAT- MEDLINE
DCOM- 20140422
LR  - 20180620
IS  - 0241-6972 (Print)
IS  - 0241-6972 (Linking)
IP  - 281
DP  - 2012 Jul-Aug
TI  - [The ethical questions raised by the law of July 5th, 2011].
PG  - 36-7
AB  - The law of 5th July 2011 raises numerous questions relating to care and the
      procedures for treating patients. Is the purpose of care getting lost in this
      legislative mosaic? What is the future of the rights of the patients, faced with 
      the world of justice ? The ethical aspect must be questioned and must bring
      together multi-professional reflections for the benefit of the care projects.
FAU - Mazodier, Marianne
AU  - Mazodier M
AD  - Groupe hospitalier Paul-Guiraud, pole 92G13, Villejuif.
      marianne.mazodier@ch-pgv.fr
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Les questions ethiques soulevees par la loi du 5 juillet 2011.
PL  - France
TA  - Soins Psychiatr
JT  - Soins. Psychiatrie
JID - 8203334
MH  - Commitment of Mentally Ill/*legislation & jurisprudence
MH  - Confidentiality/ethics/legislation & jurisprudence
MH  - Cooperative Behavior
MH  - *Ethics, Nursing
MH  - France
MH  - Health Services Accessibility/ethics/legislation & jurisprudence
MH  - Humans
MH  - Interdisciplinary Communication
MH  - Mental Disorders/*nursing/rehabilitation
MH  - Patient Advocacy/*ethics/*legislation & jurisprudence
MH  - Personal Autonomy
EDAT- 2012/08/18 06:00
MHDA- 2014/04/23 06:00
CRDT- 2012/08/18 06:00
PHST- 2012/08/18 06:00 [entrez]
PHST- 2012/08/18 06:00 [pubmed]
PHST- 2014/04/23 06:00 [medline]
AID - S0241-6972(12)00128-4 [pii]
PST - ppublish
SO  - Soins Psychiatr. 2012 Jul-Aug;(281):36-7.


PMID- 22895980
OWN - NLM
STAT- MEDLINE
DCOM- 20120926
LR  - 20220129
IS  - 1469-493X (Electronic)
IS  - 1361-6137 (Linking)
IP  - 8
DP  - 2012 Aug 15
TI  - Adrenaline auto-injectors for the treatment of anaphylaxis with and without
      cardiovascular collapse in the community.
PG  - CD008935
LID - 10.1002/14651858.CD008935.pub2 [doi]
AB  - BACKGROUND: Anaphylaxis is a serious hypersensitivity reaction that is rapid in
      onset and may cause death. Adrenaline (epinephrine) auto-injectors are
      recommended as the initial, potentially life-saving treatment of choice for
      anaphylaxis in the community, but they are not universally available and have
      limitations in their use. OBJECTIVES: To assess the effectiveness of adrenaline
      (epinephrine) auto-injectors in relieving respiratory, cardiovascular, and other 
      symptoms during episodes of anaphylaxis that occur in the community. SEARCH
      METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL)
      (The Cochrane Library 2012, Issue 1), MEDLINE (Ovid SP) (1950 to January 2012),
      EMBASE (Ovid SP) (1980 to January 2012 ), CINAHL (EBSCO host) (1982 to January
      2012 ), AMED (EBSCO host) (1985 to January 2012 ), LILACS, (BIREME) (1980 to
      January 2012 ), ISI Web of Science (1950 to January 2012 ). We adapted our search
      terms for other databases. We also searched websites listing on-going trials: the
      World Health Organization International Clinical Trials Registry Platform, the UK
      Clinical Research Network Study Portfolio, and the meta Register of Controlled
      Trials; and contacted pharmaceutical companies who manufacture adrenaline
      auto-injectors in an attempt to locate unpublished material. SELECTION CRITERIA: 
      Randomized and quasi-randomized controlled trials comparing auto-injector
      administration of adrenaline with any control including no intervention, placebo,
      or other adrenergic agonists were eligible for inclusion. DATA COLLECTION AND
      ANALYSIS: Two authors independently assessed articles for inclusion. MAIN
      RESULTS: None of the 1328 studies that were identified satisfied the inclusion
      criteria. AUTHORS' CONCLUSIONS: Based on this review, we cannot make any new
      recommendations on the effectiveness of adrenaline auto-injectors for the
      treatment of anaphylaxis. Although randomized, double-blind, placebo-controlled
      clinical trials of high methodological quality are necessary to define the true
      extent of benefits from the administration of adrenaline in anaphylaxis via an
      auto-injector, such trials are unlikely to be performed in individuals
      experiencing anaphylaxis because of ethical concerns associated with
      randomization to placebo. There is, however, a need to consider trials in which, 
      for example, auto-injectors of different doses of adrenaline and differing
      devices are compared in order to provide greater clarity on the dose and device
      of choice. Such trials would be practically challenging to conduct. In the
      absence of appropriate trials, we recommend that adrenaline administration by
      auto-injector should still be regarded as the most effective first-line treatment
      for the management of anaphylaxis in the community. In countries where
      auto-injectors are not commonly used, it may be possible to conduct trials to
      compare administration of adrenaline via auto-injector with adrenaline
      administered by syringe and ampoule, or comparing the effectiveness of two
      different types of auto-injector.
FAU - Sheikh, Aziz
AU  - Sheikh A
AD  - Centre for Population Health Sciences, The University of Edinburgh, Edinburgh,
      UK. Aziz.Sheikh@ed.ac.uk.
FAU - Simons, F Estelle R
AU  - Simons FE
FAU - Barbour, Victoria
AU  - Barbour V
FAU - Worth, Allison
AU  - Worth A
LA  - eng
GR  - CZH/4/429/CSO_/Chief Scientist Office/United Kingdom
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20120815
PL  - England
TA  - Cochrane Database Syst Rev
JT  - The Cochrane database of systematic reviews
JID - 100909747
RN  - 0 (Adrenergic Agonists)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Adrenergic Agonists/*administration & dosage
MH  - Anaphylaxis/*drug therapy
MH  - Epinephrine/*administration & dosage
MH  - Humans
MH  - Injections, Intramuscular/*instrumentation
MH  - Self Administration/*instrumentation
PMC - PMC6516978
EDAT- 2012/08/17 06:00
MHDA- 2012/09/27 06:00
CRDT- 2012/08/17 06:00
PHST- 2012/08/17 06:00 [entrez]
PHST- 2012/08/17 06:00 [pubmed]
PHST- 2012/09/27 06:00 [medline]
AID - 10.1002/14651858.CD008935.pub2 [doi]
PST - epublish
SO  - Cochrane Database Syst Rev. 2012 Aug 15;(8):CD008935. doi:
      10.1002/14651858.CD008935.pub2.


PMID- 22895972
OWN - NLM
STAT- MEDLINE
DCOM- 20120926
LR  - 20200511
IS  - 1469-493X (Electronic)
IS  - 1361-6137 (Linking)
IP  - 8
DP  - 2012 Aug 15
TI  - Embolisation for pulmonary arteriovenous malformation.
PG  - CD008017
LID - 10.1002/14651858.CD008017.pub3 [doi]
AB  - BACKGROUND: Pulmonary arteriovenous malformations are abnormal direct connections
      between the pulmonary artery and pulmonary vein which result in a right-to-left
      shunt. They are associated with substantial morbidity and mortality mainly from
      the effects of paradoxical emboli. Potential complications include stroke,
      cerebral abscess, pulmonary haemorrhage and hypoxaemia. Embolisation is an
      endovascular intervention based on the occlusion of the feeding arteries the
      pulmonary arteriovenous malformations thus eliminating the abnormal
      right-to-left-shunting. OBJECTIVES: To determine the efficacy and safety of
      embolisation in patients with pulmonary arteriovenous malformations including a
      comparison with surgical resection and different embolisation devices. SEARCH
      METHODS: We searched the Cystic Fibrosis and Genetic Disorders Group's Trials
      Register; date of last search: 09 February 2012.We also searched the following
      databases: the Australian New Zealand Clinical Trials Registry;
      ClinicalTrials.gov; International Standard Randomised Controlled Trial Number
      Register; International Clinical Trials Registry Platform Search Portal (last
      searched 15 May 2012).We checked cross-references and searched references from
      review articles. SELECTION CRITERIA: Trials in which individuals with pulmonary
      arteriovenous malformations were randomly allocated to embolisation compared to
      no treatment, surgical resection or embolisation using a different embolisation
      device. DATA COLLECTION AND ANALYSIS: Studies identified for potential inclusion 
      were independently assessed for eligibility by two authors, with excluded studies
      further checked by a third author. No trials were identified for inclusion in the
      review and hence no analysis was performed. MAIN RESULTS: There were no
      randomised controlled trials identified. AUTHORS' CONCLUSIONS: There is no
      evidence from randomised controlled trials for embolisation of pulmonary
      arteriovenous malformations. However, randomised controlled trials are not always
      feasible on ethical grounds. Accumulated data from observational studies suggest 
      that embolisation reduces morbidity. A standardised approach to reporting with
      long-term follow-up through registry studies can help to strengthen the evidence 
      for embolisation in the absence of randomised controlled trials.
FAU - Hsu, Charlie C-T
AU  - Hsu CC
AD  - Department of Radiology, Princess Alexandra Hospital, Brisbane,
      Australia.charlie.ct.hsu@gmail.com
FAU - Kwan, Gigi N C
AU  - Kwan GN
FAU - Thompson, Shane A
AU  - Thompson SA
FAU - Evans-Barns, Hannah
AU  - Evans-Barns H
FAU - van Driel, Mieke L
AU  - van Driel ML
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20120815
PL  - England
TA  - Cochrane Database Syst Rev
JT  - The Cochrane database of systematic reviews
JID - 100909747
SB  - IM
UIN - Cochrane Database Syst Rev. 2015;1:CD008017. PMID: 25634560
UOF - Cochrane Database Syst Rev. 2010;(5):CD008017. PMID: 20464760
MH  - Arteriovenous Malformations/*therapy
MH  - Embolization, Therapeutic/adverse effects/*methods
MH  - Humans
MH  - Pulmonary Artery/*abnormalities
MH  - Pulmonary Veins/*abnormalities
EDAT- 2012/08/17 06:00
MHDA- 2012/09/27 06:00
CRDT- 2012/08/17 06:00
PHST- 2012/08/17 06:00 [entrez]
PHST- 2012/08/17 06:00 [pubmed]
PHST- 2012/09/27 06:00 [medline]
AID - 10.1002/14651858.CD008017.pub3 [doi]
PST - epublish
SO  - Cochrane Database Syst Rev. 2012 Aug 15;(8):CD008017. doi:
      10.1002/14651858.CD008017.pub3.


PMID- 22895637
OWN - NLM
STAT- MEDLINE
DCOM- 20131112
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 18
IP  - 3
DP  - 2012 Sep
TI  - The spirituality of human consciousness: a Catholic evaluation of some current
      neuro-scientific interpretations.
PG  - 483-501
LID - 10.1007/s11948-012-9387-2 [doi]
AB  - Catholic theology's traditional understanding of the spiritual nature of the
      human person begins with the idea of a rational soul and human mind that is made 
      manifest in free will--the spiritual experience of the act of consciousness and
      cause of all human arts. The rationale for this religion-based idea of personhood
      is key to understanding ethical dilemmas posed by modern research that applies a 
      more empirical methodology in its interpretations about the cause of human
      consciousness. Applications of these beliefs about the body/soul composite to the
      theory of evolution and to discoveries in neuroscience, paleoanthropology, as
      well as to recent animal intelligence studies, can be interpreted from this
      religious and philosophical perspective, which argues for the human soul as the
      unifying cause of the person's unique abilities. Free will and consciousness are 
      at the nexus of the mutual influence of body and soul upon one another in the
      traditional Catholic view, that argues for a spiritual dimension to personality
      that is on a par with the physical metabolic processes at play. Therapies that
      affect consciousness are ethically problematic, because of their implications for
      free will and human dignity. Studies of resilience, as an example, argue for the 
      greater, albeit limited, role of the soul's conscious choices in healing as
      opposed to metabolic or physical changes to the brain alone.
FAU - McGoldrick, Terence A
AU  - McGoldrick TA
AD  - Department of Theology, Providence College, Providence, RI, USA.
      tmcgoldr@providence.edu
LA  - eng
PT  - Journal Article
DEP - 20120816
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
CIN - Sci Eng Ethics. 2012 Sep;18(3):503-7. PMID: 22865511
MH  - Animals
MH  - *Catholicism
MH  - Consciousness/*ethics
MH  - *Culture
MH  - Humans
MH  - Morals
MH  - Neurosciences/*ethics
MH  - *Personal Autonomy
MH  - Personality
MH  - Personhood
MH  - Psychophysiology/*ethics
MH  - *Spirituality
EDAT- 2012/08/17 06:00
MHDA- 2013/11/13 06:00
CRDT- 2012/08/17 06:00
PHST- 2008/04/02 00:00 [received]
PHST- 2012/06/20 00:00 [accepted]
PHST- 2012/08/17 06:00 [entrez]
PHST- 2012/08/17 06:00 [pubmed]
PHST- 2013/11/13 06:00 [medline]
AID - 10.1007/s11948-012-9387-2 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2012 Sep;18(3):483-501. doi: 10.1007/s11948-012-9387-2. Epub 2012
      Aug 16.


PMID- 22895636
OWN - NLM
STAT- MEDLINE
DCOM- 20140122
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 3
DP  - 2013 Sep
TI  - An experiential, game-theoretic pedagogy for sustainability ethics.
PG  - 1323-39
LID - 10.1007/s11948-012-9385-4 [doi]
AB  - The wicked problems that constitute sustainability require students to learn a
      different set of ethical skills than is ordinarily required by professional
      ethics. The focus for sustainability ethics must be redirected towards: (1)
      reasoning rather than rules, and (2) groups rather than individuals. This need
      for a different skill set presents several pedagogical challenges to traditional 
      programs of ethics education that emphasize abstraction and reflection at the
      expense of experimentation and experience. This paper describes a novel pedagogy 
      of sustainability ethics that is based on noncooperative, game-theoretic problems
      that cause students to confront two salient questions: "What are my obligations
      to others?" and "What am I willing to risk in my own well-being to meet those
      obligations?" In comparison to traditional professional ethics education, the
      game-based pedagogy moves the learning experience from: passive to active,
      apathetic to emotionally invested, narratively closed to experimentally open, and
      from predictable to surprising. In the context of game play, where players must
      make decisions that can adversely impact classmates, students typically discover 
      a significant gap between their moral aspirations and their moral actions. When
      the games are delivered sequentially as part of a full course in Sustainability
      Ethics, students may experience a moral identity crisis as they reflect upon the 
      incongruity of their self-understanding and their behavior. Repeated play allows 
      students to reconcile this discrepancy through group deliberation that
      coordinates individual decisions to achieve collective outcomes. It is our
      experience that students gradually progress through increased levels of group
      tacit knowledge as they encounter increasingly complex game situations.
FAU - Sadowski, Jathan
AU  - Sadowski J
AD  - School of Sustainable Engineering and the Built Environment, Arizona State
      University, Tempe, AZ, USA. Jathan.Sadowski@asu.edu
FAU - Seager, Thomas P
AU  - Seager TP
FAU - Selinger, Evan
AU  - Selinger E
FAU - Spierre, Susan G
AU  - Spierre SG
FAU - Whyte, Kyle P
AU  - Whyte KP
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20120816
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Conservation of Natural Resources
MH  - Curriculum
MH  - Decision Making/*ethics
MH  - Emotions
MH  - Engineering/ethics
MH  - Ethics, Professional/*education
MH  - Ethics, Research/*education
MH  - *Game Theory
MH  - Group Processes
MH  - Humans
MH  - Identity Crisis
MH  - *Moral Obligations
MH  - Science/ethics
MH  - Self Concept
MH  - Students
MH  - Teaching/*methods
EDAT- 2012/08/17 06:00
MHDA- 2014/01/23 06:00
CRDT- 2012/08/17 06:00
PHST- 2012/03/27 00:00 [received]
PHST- 2012/07/18 00:00 [accepted]
PHST- 2012/08/17 06:00 [entrez]
PHST- 2012/08/17 06:00 [pubmed]
PHST- 2014/01/23 06:00 [medline]
AID - 10.1007/s11948-012-9385-4 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Sep;19(3):1323-39. doi: 10.1007/s11948-012-9385-4. Epub 2012
      Aug 16.


PMID- 22894696
OWN - NLM
STAT- MEDLINE
DCOM- 20121226
LR  - 20120816
IS  - 1936-9727 (Electronic)
IS  - 1936-9719 (Linking)
VI  - 70
IP  - 1
DP  - 2012
TI  - Ethics in sports medicine.
PG  - 56-9
AB  - All physicians are faced at some time with fundamental challenges while striving 
      to respect the principle canons which define a physician's ethical code. These
      canons are: 1. Primacy of patient interests, 2. Patient confidentiality, 3,
      Informed consent, and 4. Maintenance of a high standard of care. Athletes,
      because of their focus on performance, often present unique situations which lead
      to ethical challenges not seen in the general patient population. Adherence to
      the four principle ethical canons guides physicians to make ethical decisions
      when dealing with these unique patients.
FAU - Murthy, Anjali M
AU  - Murthy AM
AD  - The Permanente Medical Group, Inc., Vallejo, California 10003, USA.
FAU - Dwyer, James
AU  - Dwyer J
FAU - Bosco, Joseph A
AU  - Bosco JA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Bull NYU Hosp Jt Dis
JT  - Bulletin of the NYU hospital for joint diseases
JID - 101300541
SB  - IM
MH  - Attitude of Health Personnel
MH  - Confidentiality/ethics
MH  - Doping in Sports/ethics
MH  - *Ethics, Medical
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Informed Consent/ethics
MH  - Orthopedics/*ethics/standards
MH  - Patient Rights/*ethics/standards
MH  - Personnel Loyalty
MH  - Professional Autonomy
MH  - Sports Medicine/*ethics/standards
MH  - Standard of Care/ethics
EDAT- 2012/08/17 06:00
MHDA- 2012/12/27 06:00
CRDT- 2012/08/17 06:00
PHST- 2012/08/17 06:00 [entrez]
PHST- 2012/08/17 06:00 [pubmed]
PHST- 2012/12/27 06:00 [medline]
PST - ppublish
SO  - Bull NYU Hosp Jt Dis. 2012;70(1):56-9.


PMID- 22893668
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20220310
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 4
DP  - 2012
TI  - Longitudinal cohort protocol study of oropharyngeal dysphagia: relationships to
      gross motor attainment, growth and nutritional status in preschool children with 
      cerebral palsy.
LID - 10.1136/bmjopen-2012-001460 [doi]
LID - e001460 [pii]
AB  - INTRODUCTION: The prevalence of oropharyngeal dysphagia (OPD) in children with
      cerebral palsy (CP) is estimated to be between 19% and 99%. OPD can impact on
      children's growth, nutrition and overall health. Despite the growing recognition 
      of the extent and significance of health issues relating to OPD in children with 
      CP, lack of knowledge of its profile in this subpopulation remains. This study
      aims to investigate the relationship between OPD, attainment of gross motor
      skills, growth and nutritional status in young children with CP at and between
      two crucial age points, 18-24 and 36 months, corrected age. METHODS AND ANALYSIS:
      This prospective longitudinal population-based study aims to recruit a total of
      200 children with CP born in Queensland, Australia between 1 September 2006 and
      31 December 2009 (60 per birth-year). Outcomes include clinically assessed OPD
      (Schedule for Oral Motor Assessment, Dysphagia Disorders Survey, Pre-Speech
      Assessment Scale, signs suggestive of pharyngeal phase impairment, Thomas-Stonell
      and Greenberg Saliva Severity Scale), parent-reported OPD on a feeding
      questionnaire, gross motor skills (Gross Motor Function Measure, Gross Motor
      Function Classification System and motor type), growth and nutritional status
      (linear growth and body composition) and dietary intake (3 day food record). The 
      strength of relationship between outcome and exposure variables will be analysed 
      using regression modelling with ORs and relative risk ratios. ETHICS AND
      DISSEMINATION: This protocol describes a study that provides the first large
      population-based study of OPD in a representative sample of preschool children
      with CP, using direct clinical assessment. Ethics has been obtained through the
      University of Queensland Medical Research Ethics Committee, the Children's Health
      Services District Ethics Committee, and at other regional and organisational
      ethics committees. Results are planned to be disseminated in six papers submitted
      to peer reviewed journals, and presentations at relevant international
      conferences.
FAU - Benfer, Katherine A
AU  - Benfer KA
AD  - Queensland Cerebral Palsy and Rehabilitation Research Centre, Discipline of
      Paediatrics and Child Health, School of Medicine, The University of Queensland,
      Brisbane, Australia.
FAU - Weir, Kelly A
AU  - Weir KA
FAU - Bell, Kristie L
AU  - Bell KL
FAU - Ware, Robert S
AU  - Ware RS
FAU - Davies, Peter S W
AU  - Davies PS
FAU - Boyd, Roslyn N
AU  - Boyd RN
LA  - eng
PT  - Journal Article
DEP - 20120813
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
EIN - BMJ Open. 2012 Sep 13;2(5):null. PMID: 22977186
PMC - PMC3425902
EDAT- 2012/08/16 06:00
MHDA- 2012/08/16 06:01
CRDT- 2012/08/16 06:00
PHST- 2012/08/16 06:00 [entrez]
PHST- 2012/08/16 06:00 [pubmed]
PHST- 2012/08/16 06:01 [medline]
AID - bmjopen-2012-001460 [pii]
AID - 10.1136/bmjopen-2012-001460 [doi]
PST - epublish
SO  - BMJ Open. 2012 Aug 13;2(4). pii: bmjopen-2012-001460. doi:
      10.1136/bmjopen-2012-001460. Print 2012.


PMID- 22893666
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20220129
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 4
DP  - 2012
TI  - A 24-h helpline for access to expert management advice for food allergy-related
      anaphylaxis in children: protocol for a pragmatic randomised controlled trial.
LID - 10.1136/bmjopen-2012-001282 [doi]
LID - e001282 [pii]
AB  - OBJECTIVES: Anaphylaxis is an important, potentially life-threatening paediatric 
      emergency. It is responsible for considerable morbidity and, in some cases,
      death. Poor outcomes may be associated with an inability to differentiate between
      milder and potentially more severe reactions and an associated reluctance to
      administer self-injectable adrenaline. This study aims to assess the
      effectiveness of a 24-h telephone access to specialist paediatric allergy expert 
      advice in improving the quality of life of children and their families with
      potentially life-threatening food allergy (ie, anaphylaxis) compared with usual
      clinical care. METHODS AND ANALYSIS: Children aged less than 16 years with food
      allergy and who carry an adrenaline autoinjector will be recruited from the
      Paediatric Allergy Clinic at Cork University Hospital, Ireland and baseline
      disease-specific quality of life will be ascertained using the validated Food
      Allergy Quality of Life Questionnaire (FAQLQ). Participants will be randomised
      for a period of 6 months to the 24-h telephone specialist support line or usual
      care. The primary outcome measure of interest is a change in FAQLQ scores, which 
      will be assessed at 0, 1 and 6 months postrandomisation. Analysis will be on an
      intention-to-treat basis using a 2x3 repeated measures within-between analysis of
      variance. Although lacking power, we will in addition assess the impact of the
      intervention on a range of relevant process and clinical endpoints. ETHICS AND
      DISSEMINATION: This trial protocol has been approved by the Clinical Research
      Ethics Committee of the Cork Teaching Hospitals. The findings will be presented
      at international scientific conferences and will be reported on in the
      peer-reviewed literature in early 2013.
FAU - Kelleher, Maeve M
AU  - Kelleher MM
AD  - Department of Paediatrics and Child Health, University College Cork, Cork,
      Ireland.
FAU - Hourihane, Jonathan O'B
AU  - Hourihane JO
FAU - Dunngalvin, Audrey
AU  - Dunngalvin A
FAU - Cullinane, Claire
AU  - Cullinane C
FAU - Fitzsimons, John
AU  - Fitzsimons J
FAU - Sheikh, Aziz
AU  - Sheikh A
LA  - eng
GR  - CZG/2/454/CSO_/Chief Scientist Office/United Kingdom
PT  - Journal Article
DEP - 20120813
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3425896
EDAT- 2012/08/16 06:00
MHDA- 2012/08/16 06:01
CRDT- 2012/08/16 06:00
PHST- 2012/08/16 06:00 [entrez]
PHST- 2012/08/16 06:00 [pubmed]
PHST- 2012/08/16 06:01 [medline]
AID - bmjopen-2012-001282 [pii]
AID - 10.1136/bmjopen-2012-001282 [doi]
PST - epublish
SO  - BMJ Open. 2012 Aug 13;2(4). pii: bmjopen-2012-001282. doi:
      10.1136/bmjopen-2012-001282. Print 2012.


PMID- 22893572
OWN - NLM
STAT- MEDLINE
DCOM- 20150512
LR  - 20131216
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 40
IP  - 1
DP  - 2014 Jan
TI  - Dignity and the use of body parts.
PG  - 44-7
LID - 10.1136/medethics-2012-100763 [doi]
AB  - This paper contends that the conventional ethical and legal ways of analysing the
      wrong involved in the misuse of human body parts are inadequate, and should be
      replaced with an analysis based on human dignity. It examines the various ways in
      which dignity has been understood, outlines many of the criticisms made of those 
      ways (agreeing with many of the criticisms), and proposes a new way of seeing
      dignity which is exegetically consonant with the way in which dignity has been
      historically understood, and yet avoids the pitfalls which have led to dignity
      being dismissed by many as hopelessly amorphous or incurably theological. The
      account of dignity proposed is broadly Aristotelian. It defines dignity in terms 
      of human thriving, and presupposes that it is possible, at least in principle, to
      determine empirically what makes humans thrive. It contends that humans are
      quintessentially relational animals, and that it is not possible (and certainly
      not ethically desirable) to define humans as atomistic entities. One important
      corollary of this is that when using dignity/thriving as a criterion for
      determining the ethical acceptability of a proposed action or inaction, one
      should ask not merely how the dignity interests of the patient (for instance)
      would be affected, but how the dignity interests of all stakeholders would be
      affected. The business of ethics is then the business of auditing all those
      interests, and determining the course of action which would maximise the amount
      of thriving in the world.
FAU - Foster, Charles
AU  - Foster C
LA  - eng
PT  - Journal Article
DEP - 20120814
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Bioethics
MH  - Commerce/legislation & jurisprudence
MH  - Ethics, Medical
MH  - *Human Body
MH  - Human Rights
MH  - Humans
MH  - Legislation as Topic
MH  - Ownership/*ethics/*legislation & jurisprudence
MH  - Personal Autonomy
MH  - *Personhood
MH  - Tissue and Organ Procurement
OTO - NOTNLM
OT  - Autonomy
OT  - Bills, Laws and Cases
OT  - Donation/Procurement of Organs/Tissues
OT  - Law
EDAT- 2012/08/16 06:00
MHDA- 2015/05/13 06:00
CRDT- 2012/08/16 06:00
PHST- 2012/08/16 06:00 [entrez]
PHST- 2012/08/16 06:00 [pubmed]
PHST- 2015/05/13 06:00 [medline]
AID - medethics-2012-100763 [pii]
AID - 10.1136/medethics-2012-100763 [doi]
PST - ppublish
SO  - J Med Ethics. 2014 Jan;40(1):44-7. doi: 10.1136/medethics-2012-100763. Epub 2012 
      Aug 14.


PMID- 22893530
OWN - NLM
STAT- MEDLINE
DCOM- 20140716
LR  - 20181202
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 9
DP  - 2013 Sep
TI  - When they believe in miracles.
PG  - 582-3
LID - 10.1136/medethics-2012-100677 [doi]
AB  - Brierley et al argue that in cases where it is medically futile to continue
      providing life-sustaining therapies to children in intensive care, medical
      professionals should be allowed to withdraw such therapies, even when the parents
      of these children believe that there is a chance of a miracle cure taking place. 
      In reasoning this way, Brierley et al appear to implicitly assume that miracle
      cures will never take place, but they do not justify this assumption and it would
      be very difficult for them to do so. Instead of seeking to override the wishes of
      parents, who are waiting for a miracle, it is suggested that a better response
      may be to seek to engage devout parents on their own terms, and encourage them to
      think about whether or not continuing life-sustaining therapies will make it more
      likely that a miracle cure will occur.
FAU - Clarke, Steve
AU  - Clarke S
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20120813
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
CON - J Med Ethics. 2013 Sep;39(9):573-7. PMID: 22465877
MH  - Humans
MH  - Intensive Care Units, Pediatric/*ethics
MH  - *Religion and Psychology
MH  - Withholding Treatment/*ethics
OTO - NOTNLM
OT  - Care of dying minors
OT  - informed consent
OT  - moral psychology
OT  - philosophical ethics
OT  - religious ethics
EDAT- 2012/08/16 06:00
MHDA- 2014/07/17 06:00
CRDT- 2012/08/16 06:00
PHST- 2012/08/16 06:00 [entrez]
PHST- 2012/08/16 06:00 [pubmed]
PHST- 2014/07/17 06:00 [medline]
AID - medethics-2012-100677 [pii]
AID - 10.1136/medethics-2012-100677 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Sep;39(9):582-3. doi: 10.1136/medethics-2012-100677. Epub 2012
      Aug 13.


PMID- 22893528
OWN - NLM
STAT- MEDLINE
DCOM- 20140716
LR  - 20211021
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 9
DP  - 2013 Sep
TI  - Just dying: the futility of futility.
PG  - 583-4
LID - 10.1136/medethics-2012-100683 [doi]
AB  - I argue that Brierley et al are wrong to claim that parents who request futile
      treatment are acting against the interests of their child. A better ethical
      ground for withholding or withdrawing life-prolonging treatment is not that it is
      in the interests of the patient to die, but rather on grounds of the limitation
      of resources and the requirements of distributive justice. Put simply, not all
      treatment that might be in a person's interests must ethically be provided.
FAU - Savulescu, Julian
AU  - Savulescu J
LA  - eng
GR  - 086041/Wellcome Trust/United Kingdom
PT  - Journal Article
DEP - 20120813
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Decision Making/ethics
MH  - Dissent and Disputes
MH  - Ethics, Clinical
MH  - Humans
MH  - Medical Futility/*ethics
MH  - Resource Allocation/*ethics
MH  - Withholding Treatment/*ethics
OTO - NOTNLM
OT  - Medical ethics
EDAT- 2012/08/16 06:00
MHDA- 2014/07/17 06:00
CRDT- 2012/08/16 06:00
PHST- 2012/08/16 06:00 [entrez]
PHST- 2012/08/16 06:00 [pubmed]
PHST- 2014/07/17 06:00 [medline]
AID - medethics-2012-100683 [pii]
AID - 10.1136/medethics-2012-100683 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Sep;39(9):583-4. doi: 10.1136/medethics-2012-100683. Epub 2012
      Aug 13.


PMID- 22893215
OWN - NLM
STAT- MEDLINE
DCOM- 20130208
LR  - 20211021
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 24
IP  - 3
DP  - 2012 Sep
TI  - The benefits of practice standards and other practice-defining texts: and why
      healthcare ethicists ought to explore them.
PG  - 203-17
LID - 10.1007/s10730-012-9186-9 [doi]
AB  - This article outlines one element of the work carried out by a group of Canadian 
      ethicists [Practicing Healthcare Ethicists Exploring Professionalization
      (PHEEP)]--to begin the deliberative development of a set of practice standards
      for the Canadian context. To provide a backdrop, this article considers the
      nature and purpose of practice standards as they are used by regulated
      professions and how they relate to other practice-defining texts such as
      competencies, codes of ethics and statements of scope of practice. A comparative 
      review of current practice-defining documents developed within the field of
      healthcare ethics practice suggests that practice standards are not yet among
      them. A review of the practice standards and related texts articulated by various
      other professions, both regulated and not yet regulated, indicates that while
      these groups of documents serve to define and clarify various dimensions of
      practice in individual disciplines, there is no clear standardized approach to
      the terminology, structure and content across these documents. It is suggested
      that this variability presents a degree of flexibility that ought to allay many
      of the anxieties that have been expressed about practice standards in healthcare 
      ethics: practitioners, PHEs, are at liberty to define their practice as they see 
      fit, albeit within reasonable parameters if regulation is sought. A proposal for 
      a draft structure and potential content for Canadian healthcare ethics practice
      standards is offered.
FAU - Reel, Kevin
AU  - Reel K
AD  - Mackenzie Health, Richmond Hill, ON, Canada. kevin.reel@utoronto.ca
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - Canada
MH  - Delivery of Health Care/*ethics
MH  - Ethicists/*standards
MH  - Humans
MH  - *Interdisciplinary Communication
MH  - *Professional Competence
MH  - Professional Practice/*standards
EDAT- 2012/08/16 06:00
MHDA- 2013/02/09 06:00
CRDT- 2012/08/16 06:00
PHST- 2012/08/16 06:00 [entrez]
PHST- 2012/08/16 06:00 [pubmed]
PHST- 2013/02/09 06:00 [medline]
AID - 10.1007/s10730-012-9186-9 [doi]
PST - ppublish
SO  - HEC Forum. 2012 Sep;24(3):203-17. doi: 10.1007/s10730-012-9186-9.


PMID- 22893214
OWN - NLM
STAT- MEDLINE
DCOM- 20130208
LR  - 20211021
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 24
IP  - 3
DP  - 2012 Sep
TI  - The question of professionalization: a narrative.
PG  - 179-86
LID - 10.1007/s10730-012-9185-x [doi]
AB  - For quite some time now, there have been discussions and debates in North America
      in the field of ethics concerning professionalization. From a talk given to
      graduate and undergraduate university students, the author tells the personal
      journey of an ethicist in the province of Quebec, Canada, and offers a narrative 
      to illustrate some of the issues she faced since starting her work in the field
      of ethics at the end of the 1990s. Instead of taking the usual "for" and
      "against" positions, the author addresses the issue of professionalization of
      healthcare ethics from her own point of view. Referring to her experience with
      ethics committees and research ethics boards and to the works of George A.
      Legault in Crise d'identite professionnelle et Professionnalisme (Presses de
      l'Universite du Quebec, Sainte-Foy, 2003), she pleads for the development of
      practice standards and the creation of a deliberative process (see Kirby and
      Simpson in this issue of HEC Forum 2012), a dialogical space for assuring
      professionalism in healthcare ethics interventions, not solely the act of
      becoming a profession.
FAU - Roigt, Delphine
AU  - Roigt D
AD  - Centre hospitalier de l'Universite de Montreal, CHUM-Hotel-Dieu, Montreal, QC,
      Canada. delphine.roigt.chum@ssss.gouv.qc.ca
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - *Bioethics
MH  - Ethicists
MH  - Humans
MH  - *Narration
MH  - *Professional Competence
MH  - Professional Practice
MH  - *Professional Role
MH  - Quebec
EDAT- 2012/08/16 06:00
MHDA- 2013/02/09 06:00
CRDT- 2012/08/16 06:00
PHST- 2012/08/16 06:00 [entrez]
PHST- 2012/08/16 06:00 [pubmed]
PHST- 2013/02/09 06:00 [medline]
AID - 10.1007/s10730-012-9185-x [doi]
PST - ppublish
SO  - HEC Forum. 2012 Sep;24(3):179-86. doi: 10.1007/s10730-012-9185-x.


PMID- 22892018
OWN - NLM
STAT- MEDLINE
DCOM- 20130506
LR  - 20121106
IS  - 1440-1754 (Electronic)
IS  - 1034-4810 (Linking)
VI  - 48
IP  - 11
DP  - 2012 Nov
TI  - Conducting a paediatric multi-centre RCT with an industry partner: challenges and
      lessons learned.
PG  - 974-7
LID - 10.1111/j.1440-1754.2012.02510.x [doi]
AB  - There are many benefits of multi-centred research including large sample sizes,
      statistical power, timely recruitment and generalisability of results. However,
      there are numerous considerations when planning and implementing a multi-centred 
      study. This article reviews the challenges and successes of planning and
      implementing a multi-centred prospective randomised control trial involving an
      industry partner. The research investigated the impact on psychosocial
      functioning of a cosmetic camouflage product for children and adolescents with
      burn scarring. Multi-centred studies commonly have many stakeholders. Within this
      study, six Australian and New Zealand paediatric burn units as well as an
      industry partner were involved. The inclusion of an industry partner added
      complexities as they brought different priorities and expectations to the
      research. Further, multifaceted ethical and institutional approval processes
      needed to be negotiated. The challenges, successes, lessons learned and
      recommendations from this study regarding Australian and New Zealand ethics and
      research governance approval processes, collaboration with industry partners and 
      the management of differing expectations will be outlined. Recommendations for
      future multi-centred research with industry partners include provision of regular
      written reports for the industry partner; continual monitoring and prompt
      resolution of concerns; basic research practices education for industry partners;
      minimisation of industry partner contact with participants; clear roles and
      responsibilities of all stakeholders and utilisation of single ethical review if 
      available.
CI  - (c) 2012 The Authors. Journal of Paediatrics and Child Health (c) 2012
      Paediatrics and Child Health Division (Royal Australasian College of Physicians).
FAU - Maskell, Jessica
AU  - Maskell J
AD  - Department of Paediatrics and Child Health, The University of Queensland,
      Brisbane, Australia. jessica.jameschadwick@uqconnect.edu.au
FAU - Newcombe, Peter
AU  - Newcombe P
FAU - Martin, Graham
AU  - Martin G
FAU - Kimble, Roy
AU  - Kimble R
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
DEP - 20120814
PL  - Australia
TA  - J Paediatr Child Health
JT  - Journal of paediatrics and child health
JID - 9005421
RN  - 0 (Cosmetics)
SB  - IM
MH  - Adolescent
MH  - Australia
MH  - Burn Units
MH  - Burns/psychology/*rehabilitation
MH  - Child
MH  - *Cooperative Behavior
MH  - Cosmetics
MH  - Humans
MH  - *Industry
MH  - Intensive Care Units, Pediatric
MH  - Interinstitutional Relations
MH  - Multicenter Studies as Topic
MH  - New Zealand
MH  - Prospective Studies
MH  - Randomized Controlled Trials as Topic
MH  - *Research Design
EDAT- 2012/08/16 06:00
MHDA- 2013/05/07 06:00
CRDT- 2012/08/16 06:00
PHST- 2012/08/16 06:00 [entrez]
PHST- 2012/08/16 06:00 [pubmed]
PHST- 2013/05/07 06:00 [medline]
AID - 10.1111/j.1440-1754.2012.02510.x [doi]
PST - ppublish
SO  - J Paediatr Child Health. 2012 Nov;48(11):974-7. doi:
      10.1111/j.1440-1754.2012.02510.x. Epub 2012 Aug 14.


PMID- 22891588
OWN - NLM
STAT- MEDLINE
DCOM- 20120911
LR  - 20141120
IS  - 0035-3639 (Print)
IS  - 0035-3639 (Linking)
VI  - 33
IP  - 3
DP  - 2012 May-Jun
TI  - [The contagion of adolescent suicide: cultural, ethical and psychosocial
      aspects].
PG  - 164-70
AB  - Suicide is the second leading cause of death among adolescents. The risk factors 
      are many and varied. The contagion of suicide was raised as a potential cause of 
      youth suicide. In support of this argument, we did a review of the literature on 
      the possible contagion of adolescent suicide. Several types of situations can
      support this hypothesis : when a youth is faced with the suicide of a relative or
      close friend, when he lived in a community, through the media or via the
      Internet. The way suicide is reported in the press shows a correlation with
      increased incidence of suicide among adolescents. In summary, there is evidence
      increasingly obvious that the contagion is the source of some youth suicides. For
      this reason, it seems important that preventive measures are in place. However,
      although this mechanism has been instrumental in initiating the act, it is
      important to note that suicide is always the result of several factors including 
      the personal history of the subject.
FAU - Gerard, N
AU  - Gerard N
AD  - Services de Pedopsychiatrie, C.H.U. Ambroise Pare. nogerard@ulb.ac.be
FAU - Delvenne, V
AU  - Delvenne V
FAU - Nicolis, H
AU  - Nicolis H
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - La contagion du suicide chez les adolescents: aspects culturels, ethiques et
      psychosociaux.
PL  - Belgium
TA  - Rev Med Brux
JT  - Revue medicale de Bruxelles
JID - 8003474
SB  - IM
MH  - Adolescent
MH  - Adolescent Behavior/*ethics/ethnology/physiology/*psychology
MH  - *Culture
MH  - Depression/complications/epidemiology/ethnology/psychology
MH  - Epidemics
MH  - Humans
MH  - Internet
MH  - Mass Media
MH  - Psychology, Adolescent/ethics
MH  - Suicide/ethics/ethnology/psychology/*statistics & numerical data
EDAT- 2012/08/16 06:00
MHDA- 2012/09/12 06:00
CRDT- 2012/08/16 06:00
PHST- 2012/08/16 06:00 [entrez]
PHST- 2012/08/16 06:00 [pubmed]
PHST- 2012/09/12 06:00 [medline]
PST - ppublish
SO  - Rev Med Brux. 2012 May-Jun;33(3):164-70.


PMID- 22891514
OWN - NLM
STAT- MEDLINE
DCOM- 20120831
LR  - 20220318
IS  - 1020-3397 (Print)
IS  - 1020-3397 (Linking)
VI  - 18
IP  - 7
DP  - 2012 Jul
TI  - Research priorities in medical education in the Eastern Mediterranean Region.
PG  - 687-92
AB  - Ways are needed to effect quality improvement in medical education research in
      the Eastern Mediterranean Region (EMR). This study aimed to determine the
      principle themes and to draw up a list of priorities in medical education
      research in EMR. Using the nominal group technique with a group of 30 experts, a 
      list of major themes in medical education research was prepared. In a 2-round
      Delphi survey the list was sent to another 47 experts in the Region with a
      questionnaire that included open questions about change and reform in medical
      education. In the final list of 20, the 5 highest priorities identified were:
      training physicians to be effective teachers; community-driven models for
      curriculum development; clinical teaching models; education about professionalism
      and ethics; and education for evidence-based medicine. Themes determined by this 
      survey can help researchers in EMR to focus on priority areas in research.
FAU - Amini, M
AU  - Amini M
AD  - Education Development and Research Centre, Shiraz University ofMedical Sciences, 
      Shiraz, Islamic Republic of Iran. aminim@sums.ac.ir
FAU - Kojuri, J
AU  - Kojuri J
FAU - Lotfi, F
AU  - Lotfi F
FAU - Karimian, Z
AU  - Karimian Z
FAU - Abadi, A S H
AU  - Abadi AS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Egypt
TA  - East Mediterr Health J
JT  - Eastern Mediterranean health journal = La revue de sante de la Mediterranee
      orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit
JID - 9608387
SB  - IM
MH  - Curriculum
MH  - Delphi Technique
MH  - Education, Medical/*organization & administration/trends
MH  - Ethics, Medical/education
MH  - Humans
MH  - Mediterranean Region
MH  - Middle East
MH  - Models, Educational
MH  - Quality Improvement/*organization & administration/standards
MH  - Research/*organization & administration/trends
EDAT- 2012/08/16 06:00
MHDA- 2012/09/01 06:00
CRDT- 2012/08/16 06:00
PHST- 2012/08/16 06:00 [entrez]
PHST- 2012/08/16 06:00 [pubmed]
PHST- 2012/09/01 06:00 [medline]
PST - ppublish
SO  - East Mediterr Health J. 2012 Jul;18(7):687-92.


PMID- 22891513
OWN - NLM
STAT- MEDLINE
DCOM- 20120831
LR  - 20191112
IS  - 1020-3397 (Print)
IS  - 1020-3397 (Linking)
VI  - 18
IP  - 7
DP  - 2012 Jul
TI  - Documentation of ethical conduct of human subject research published in Saudi
      medical journals.
PG  - 682-6
AB  - We evaluated the documentation of ethical conduct (obtaining institutional review
      board approval and consent and following ethical guidelines) of human subject
      research studies published in Saudi Arabian medical journals between 1979 and
      2007. Studies were classified as retrospective, prospective noninterventional,
      interventional or survey/interview. Of 1838 studies published in 286 journal
      issues of 11 Saudi Arabian medical journals, only 0.9% documented the ethical
      guidelines followed, with a significantly higher rate for studies published after
      year 2000 (1.7%). Of 821 studies requiring institutional review board approval,
      8.6% documented obtaining the approval and informed consent, with a significantly
      higher rate for interventional studies (19.4%), post-year 2000 studies (19.7%)
      and studies performed outside Saudi Arabia (15.9%). The low documentation rate
      suggests editor's lack of rigor and/or investigators' ignorance of guidelines.
      The higher documentation rate after year 2000 suggests an ongoing improvement.
FAU - Al-Gaai, E A
AU  - Al-Gaai EA
AD  - Centre for Clinical Studies and Empirical Ethics, King Faisal Specialist Hospital
      and Research Centre, Riyadh, Saudi Arabia.
FAU - Hammami, M M
AU  - Hammami MM
FAU - Al Eidan, M
AU  - Al Eidan M
LA  - eng
PT  - Journal Article
PL  - Egypt
TA  - East Mediterr Health J
JT  - Eastern Mediterranean health journal = La revue de sante de la Mediterranee
      orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit
JID - 9608387
SB  - IM
MH  - Documentation/*statistics & numerical data
MH  - Ethics Committees, Research/statistics & numerical data
MH  - *Ethics, Research
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Informed Consent/statistics & numerical data
MH  - Periodicals as Topic/*statistics & numerical data
MH  - Saudi Arabia
EDAT- 2012/08/16 06:00
MHDA- 2012/09/01 06:00
CRDT- 2012/08/16 06:00
PHST- 2012/08/16 06:00 [entrez]
PHST- 2012/08/16 06:00 [pubmed]
PHST- 2012/09/01 06:00 [medline]
AID - 10.26719/2012.18.7.682 [doi]
PST - ppublish
SO  - East Mediterr Health J. 2012 Jul;18(7):682-6. doi: 10.26719/2012.18.7.682.


PMID- 22891357
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20220408
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 265
IP  - 1
DP  - 2012 Oct
TI  - Natural course of extrahepatic nonmalignant partial portal vein thrombosis in
      patients with cirrhosis.
PG  - 124-32
AB  - PURPOSE: To define the natural course of extrahepatic nonmalignant partial portal
      vein thrombosis (PVT), including the progression from partial to complete PVT, in
      patients with cirrhosis who had undergone multidetector computed tomography (CT).
      MATERIALS AND METHODS: This study was institutional review board and ethics
      committee approved. Written informed consent was obtained for each procedure.
      Forty-two consecutive patients with cirrhosis and untreated extrahepatic,
      nonmalignant partial PVT were followed up until the final clinical evaluation,
      liver transplantation, or death. Multidetector CT was used to evaluate the
      thrombus lumen occlusion, patent lumen area, thrombus area, total lumen area, and
      diameter of main portal vein, superior mesenteric vein, and splenic vein.
      Statistical analysis was performed with the Wilcoxon Mann-Whitney U test, chi2
      test, Wilcoxon matched-pairs signed-rank test, life-table analysis, Kaplan-Meier 
      method, and log-rank test, as appropriate. RESULTS: After a mean follow-up period
      of 27 months, partial PVT worsened in 20 (48%) patients, improved in 19 (45%),
      and was stable in three (7%). The Kaplan-Meier probability of episodes of hepatic
      decompensation at 1 and 2 years was 41% and 57%; probability of hospital
      admission for hepatic decompensation, 37% and 54%; and survival rates, 77% and
      57%, respectively. There was no clear association between progression or
      regression of partial PVT and clinical outcome. Multivariate analysis showed that
      the Child-Pugh score at diagnosis was the only independent predictor of survival 
      (hazard ratio, 1.97; 95% confidence interval: 1.19, 3.23; P=.007) and hepatic
      decompensation (hazard ratio, 1.51; 95% confidence interval: 1.18, 1.19; P=.001).
      CONCLUSION: Extrahepatic nonmalignant partial PVT improved spontaneously in 45%
      of patients with cirrhosis, and the progression of partial PVT was not associated
      with clinical outcome, which appeared to be dependent on the severity of
      cirrhosis.
CI  - (c) RSNA, 2012.
FAU - Luca, Angelo
AU  - Luca A
AD  - Department of Diagnostic and Therapeutics Services, Mediterranean Institute for
      Transplantation and Advanced Specialized Therapies, Via Tricomi 1, 90127 Palermo,
      Italy. aluca@ismett.edu
FAU - Caruso, Settimo
AU  - Caruso S
FAU - Milazzo, Mariapina
AU  - Milazzo M
FAU - Marrone, Gianluca
AU  - Marrone G
FAU - Mamone, Giuseppe
AU  - Mamone G
FAU - Crino, Francesca
AU  - Crino F
FAU - Maruzzelli, Luigi
AU  - Maruzzelli L
FAU - Miraglia, Roberto
AU  - Miraglia R
FAU - Floridia, Gaetano
AU  - Floridia G
FAU - Vizzini, Giovanni
AU  - Vizzini G
LA  - eng
PT  - Journal Article
DEP - 20120813
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
SB  - IM
CIN - Radiology. 2013 Mar;266(3):994-5. PMID: 23431230
MH  - Adult
MH  - Aged
MH  - Chi-Square Distribution
MH  - Contrast Media
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Liver Cirrhosis/diagnostic imaging/*pathology
MH  - Male
MH  - Middle Aged
MH  - Portal Vein/diagnostic imaging/*pathology
MH  - Remission, Spontaneous
MH  - Retrospective Studies
MH  - Statistics, Nonparametric
MH  - Survival Analysis
MH  - *Tomography, X-Ray Computed
MH  - Venous Thrombosis/diagnostic imaging/*pathology
EDAT- 2012/08/15 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/08/15 06:00
PHST- 2012/08/15 06:00 [entrez]
PHST- 2012/08/15 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - radiol.12112236 [pii]
AID - 10.1148/radiol.12112236 [doi]
PST - ppublish
SO  - Radiology. 2012 Oct;265(1):124-32. doi: 10.1148/radiol.12112236. Epub 2012 Aug
      13.


PMID- 22891089
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20211021
IS  - 1937-8688 (Electronic)
VI  - 12
DP  - 2012
TI  - Knowledge and misconceptions about HIV counseling and testing (HCT) among the
      post-conflict youths of Gulu, Northern Uganda. A prospective study design.
PG  - 31
AB  - BACKGROUND: Uganda has been reported as the most successful country in Africa in 
      reducing the prevalence of HIV/AIDS from 18% to 6.4% over the last two decades.
      There is evidence to suggest that despite a significant decline between 1992 and 
      2002, HIV prevalence has stagnated over the last 5-9 years at between 6.1 and
      6.5% and it is rising in some parts of the country such as Gulu. This rise are
      thought to be due to the high levels of stigma and superstition preventing HIV
      counseling and testing (HCT). WHO reports in 2009 showed that only 20% of
      Uganda's populations knew their HIV sero-status. This study was designed to find 
      out the knowledge, misconceptions, attitude and practices of youths of Gulu about
      HCT. METHODS: A cross-sectional study was conducted in Gulu, Pece among the
      youths 15 to 35 years. An in-depth interview using a questionnaire was
      administered to youths of Commercial Road Sub-ward. Informed consent and ethical 
      approval was obtained and 86 respondents were interviewed. RESULTS: Ninety three 
      percent of respondents had knowledge about HCT and 97.7% were able to mention two
      or more of its benefits. Most (88.4%) agreed on public disclosure of their HIV
      status and 84.9% would encourage others to undertake it. Only 36.1% of
      respondents had undertaken HCT while the rest had not undertaken it due to fear
      of stigmatization. CONCLUSION: There is adequate knowledge, good attitude but
      poor practice and misconceptions to HCT. The young adults in Gulu should be
      supported in a special program to enable them undertake HCT and access other
      services for HIV/AIDS prevention.
FAU - Kitara, David Lagoro
AU  - Kitara DL
AD  - Gulu University, Faculty of Medicine, Gulu, Uganda.
FAU - Amone, Charles
AU  - Amone C
FAU - Okello, Christopher
AU  - Okello C
LA  - eng
PT  - Journal Article
DEP - 20120614
PL  - Uganda
TA  - Pan Afr Med J
JT  - The Pan African medical journal
JID - 101517926
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cross-Sectional Studies
MH  - *Directive Counseling
MH  - Female
MH  - HIV Infections/*diagnosis
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Male
MH  - Prospective Studies
MH  - Uganda
MH  - Warfare
MH  - Young Adult
PMC - PMC3415052
OTO - NOTNLM
OT  - HIV counseling and testing (HCT)
OT  - Knowledge
OT  - Uganda
OT  - post-conflict
OT  - youths
EDAT- 2012/08/15 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/08/15 06:00
PHST- 2011/05/17 00:00 [received]
PHST- 2012/01/24 00:00 [accepted]
PHST- 2012/08/15 06:00 [entrez]
PHST- 2012/08/15 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
PST - ppublish
SO  - Pan Afr Med J. 2012;12:31. Epub 2012 Jun 14.


PMID- 22890685
OWN - NLM
STAT- MEDLINE
DCOM- 20130116
LR  - 20120823
IS  - 1496-8975 (Electronic)
IS  - 0832-610X (Linking)
VI  - 59
IP  - 9
DP  - 2012 Sep
TI  - Competency-based professionalism in anesthesiology: continuing professional
      development.
PG  - 889-908
LID - 10.1007/s12630-012-9747-z [doi]
AB  - PURPOSE: Fulfilling the current societal expectations for professionalism in
      medicine requires a clear understanding of the specific skills, attitudes, and
      behaviours expected of practitioners. This Continuing Professional Development
      (CPD) module discusses professionalism as it relates to the practice of
      anesthesiology. PRINCIPAL FINDINGS: While many of the attributes of the
      professional are generic, performance expectations must be interpreted in a
      specialty-specific context. Anesthesiologists face challenges to their
      professionalism in the time-constrained, highly technical and stressful operating
      room environment. Ongoing shifts in the models of health care delivery require
      the adaptation of anesthesiology practice to meet changing demands. Consequently,
      anesthesiologists' practice environment has extended into preoperative assessment
      units, acute pain services, and perioperative medicine. Application of principles
      of biomedical ethics, understanding of medico-legal and regulatory aspects of
      practice, and attention to personal health and career sustainability are
      intrinsic aspects of professional practice. More recently, focus on adverse event
      management and continuous quality improvement has created the need for specific
      skill sets, which must be included in training and continuing professional
      development programs. The medical education literature suggests teaching and
      evaluation methods suited to the development of competence in all aspects of
      professionalism. Finally, professionalism requires the availability of
      remediation programs for learners and practitioners in difficulty. CONCLUSION:
      The attitudes, skills, and behaviours that define professionalism in
      anesthesiology must be taught and evaluated to establish a basic level of
      competence by the completion of specialty training. Throughout their careers,
      anesthesiologists must continue their professional development to meet current
      and future societal expectations and shifting norms of health care delivery.
FAU - McKenna, Jocelyne
AU  - McKenna J
AD  - Department of Anesthesiology, The Ottawa Hospital, University of Ottawa, Ottawa, 
      ON, Canada. jmckenna@toh.on.ca
FAU - Rosen, H David
AU  - Rosen HD
LA  - eng
LA  - fre
PT  - Journal Article
DEP - 20120814
PL  - United States
TA  - Can J Anaesth
JT  - Canadian journal of anaesthesia = Journal canadien d'anesthesie
JID - 8701709
SB  - IM
MH  - Anesthesiology/*education/organization & administration/standards
MH  - Attitude of Health Personnel
MH  - Bioethics
MH  - *Clinical Competence
MH  - Competency-Based Education
MH  - Delivery of Health Care/organization & administration
MH  - *Education, Medical, Continuing
MH  - Humans
MH  - Total Quality Management
EDAT- 2012/08/15 06:00
MHDA- 2013/01/17 06:00
CRDT- 2012/08/15 06:00
PHST- 2012/03/19 00:00 [received]
PHST- 2012/06/13 00:00 [accepted]
PHST- 2012/08/15 06:00 [entrez]
PHST- 2012/08/15 06:00 [pubmed]
PHST- 2013/01/17 06:00 [medline]
AID - 10.1007/s12630-012-9747-z [doi]
PST - ppublish
SO  - Can J Anaesth. 2012 Sep;59(9):889-908. doi: 10.1007/s12630-012-9747-z. Epub 2012 
      Aug 14.


PMID- 22890482
OWN - NLM
STAT- MEDLINE
DCOM- 20130701
LR  - 20211021
IS  - 1573-7438 (Electronic)
IS  - 0049-4747 (Linking)
VI  - 45
IP  - 1
DP  - 2013 Jan
TI  - Dairy goat production systems: status quo, perspectives and challenges.
PG  - 17-34
LID - 10.1007/s11250-012-0246-6 [doi]
AB  - Goat production concentrated in developing countries (tropics, dry areas),
      contributes largely to the livelihoods of low and medium income farmers. Farming 
      systems in these areas have evolved to cope with the formidable constraints
      imposed by harsh natural and economic conditions by adapting integrated
      crop/livestock production strategies. In Asia, Africa and Latin America, due to
      its almost exclusive extensive nature, goat production relies mainly on grazing
      on communal lands that hardly provide the minimum nutrient requirements due to
      overstocking and degradation. While some of these production systems are becoming
      semi-intensive, appropriate breeding strategies should be designed to promote
      conservation and improvement of their unique attributes, such as adaptability,
      water use efficiency and suitability under harsh climatic conditions. In Europe, 
      dairy goat production is more common around the Mediterranean basin, where it is 
      important from an economic, environmental and sociological perspective to the
      Mediterranean countries: Spain, France, Italy and Greece. Europe owns only 5.1 % 
      of the world's dairy goat herds, but produces 15.6 % of the world's goat milk;
      this is the only continent where goat milk has such an economic importance and
      organization. In developing countries the dairy goat sector requires a systemic
      approach, whereby nutrition, animal health, breeding, know-how, inputs and
      technologies must be assembled. This would allow the optimization of natural and 
      local resources and would promote the transition from a risk reduction strategy
      towards an increased productivity strategy. Such an increase would privilege
      production efficiency based on clean, green and ethical practices for responsible
      innovation.
FAU - Escareno, Luis
AU  - Escareno L
AD  - Division of Livestock Sciences, Department of Sustainable Agricultural Systems,
      (BOKU)-University of Natural Resources and Applied Life Sciences,
      Gregor-Mendel-Strasse 33, 1180, Vienna, Austria.
FAU - Salinas-Gonzalez, Homero
AU  - Salinas-Gonzalez H
FAU - Wurzinger, Maria
AU  - Wurzinger M
FAU - Iniguez, Luiz
AU  - Iniguez L
FAU - Solkner, Johann
AU  - Solkner J
FAU - Meza-Herrera, Cesar
AU  - Meza-Herrera C
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120814
PL  - United States
TA  - Trop Anim Health Prod
JT  - Tropical animal health and production
JID - 1277355
SB  - IM
MH  - Animal Husbandry/*methods
MH  - Animals
MH  - Breeding/*methods
MH  - Dairying/*economics/*methods/statistics & numerical data
MH  - Developing Countries
MH  - Goats/genetics/*physiology
EDAT- 2012/08/15 06:00
MHDA- 2013/07/03 06:00
CRDT- 2012/08/15 06:00
PHST- 2012/07/30 00:00 [accepted]
PHST- 2012/08/15 06:00 [entrez]
PHST- 2012/08/15 06:00 [pubmed]
PHST- 2013/07/03 06:00 [medline]
AID - 10.1007/s11250-012-0246-6 [doi]
PST - ppublish
SO  - Trop Anim Health Prod. 2013 Jan;45(1):17-34. doi: 10.1007/s11250-012-0246-6. Epub
      2012 Aug 14.


PMID- 22890341
OWN - NLM
STAT- MEDLINE
DCOM- 20160422
LR  - 20181201
IS  - 2364-0502 (Electronic)
IS  - 0943-4747 (Linking)
VI  - 7
DP  - 2012
TI  - Critical advances in bridging personal health informatics and clinical
      informatics.
PG  - 48-55
AB  - OBJECTIVES: To provide a survey over significant developments in the area of
      linking personal health informatics and clinical informatics, to give insights
      into critical advances and to discuss open problems and opportunities in this
      area. METHODS: A scoping review over the literature published in scientific
      journals and relevant conference proceedings in the intersection between personal
      health informatics and clinical informatics over the years 2010 and 2011 was
      performed. RESULTS: The publications analyzed are related to two main topics,
      namely "Sharing information and collaborating through personal health records,
      portals and social networks" and "Integration of personal health systems with
      clinical information systems". For the first topic, results are presented
      according to five different themes: "Patient expectations and attitudes", "Real
      use experiences", "Changes for care providers", "Barriers to adoption" and
      "Proposed technical infrastructures". For the second topic, two different themes 
      were found, namely "Technical architectures and interoperability" and "Security, 
      safety and privacy issues". DISCUSSION: Results show a number of gaps between the
      information needs of patients and the information care provider organizations
      provide to them as well as the lack of a trusted technical, ethical and
      regulatory framework regarding information sharing. CONCLUSIONS: Despite recent
      developments in the areas of personal health informatics and clinical informatics
      both fields have diverging needs. To support both clinical work processes and
      empower patients to effectively handle self-care, a number of issues remain
      unsolved. Open issues include privacy and confidentiality, including trusted
      sharing of health information and building collaborative environments between
      patients, their families and care providers. There are further challenges to meet
      around health and technology literacy as well as to overcome structural and
      organizational barriers. Frameworks for evaluating personal health informatics
      applications and pervasive health technology are needed to build up an evidence
      basis.
FAU - Koch, S
AU  - Koch S
AD  - Health Informatics Centre, LIME, Karolinska Institutet, SE 171 77 Stockholm,
      Sweden. E-mail: sabine.koch@ki.se.
FAU - Vimarlund, V
AU  - Vimarlund V
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Yearb Med Inform
JT  - Yearbook of medical informatics
JID - 9312666
SB  - IM
MH  - *Confidentiality
MH  - Health Records, Personal
MH  - Humans
MH  - Information Dissemination
MH  - *Medical Informatics
EDAT- 2012/08/15 06:00
MHDA- 2016/04/23 06:00
CRDT- 2012/08/15 06:00
PHST- 2012/08/15 06:00 [entrez]
PHST- 2012/08/15 06:00 [pubmed]
PHST- 2016/04/23 06:00 [medline]
AID - me12010048 [pii]
PST - ppublish
SO  - Yearb Med Inform. 2012;7:48-55.


PMID- 22890336
OWN - NLM
STAT- MEDLINE
DCOM- 20160422
LR  - 20181201
IS  - 2364-0502 (Electronic)
IS  - 0943-4747 (Linking)
VI  - 7
DP  - 2012
TI  - Self-Tracking, Social Media and Personal Health Records for Patient Empowered
      Self-Care. Contribution of the IMIA Social Media Working Group.
PG  - 16-24
AB  - OBJECTIVES: This paper explores the range of self-tracking devices and social
      media platforms used by the self-tracking community, and examines the
      implications of widespread adoption of these tools for scientific progress in
      health informatics. METHODS: A literature review was performed to investigate the
      use of social media and self-tracking technologies in the health sector. An
      environmental scan identified a range of products and services which were used to
      exemplify three levels of self-tracking: self-experimentation, social sharing of 
      data and patient controlled electronic health records. RESULTS: There appears to 
      be an increase in the use of self-tracking tools, particularly in the health and 
      fitness sector, but also used in the management of chronic diseases. Evidence of 
      efficacy and effectiveness is limited to date, primarily due to the health and
      fitness focus of current solutions as opposed to their use in disease management.
      CONCLUSIONS: Several key technologies are converging to produce a trend of
      increased personal health surveillance and monitoring, social connectedness and
      sharing, and integration of regional and national health information systems.
      These trends are enabling new applications of scientific techniques, from
      personal experimentation to e-epidemiology, as data gathered by individuals are
      aggregated and shared across increasingly connected healthcare networks. These
      trends also raise significant new ethical and scientific issues that will need to
      be addressed, both by health informatics researchers and the communities of
      self-trackers themselves.
FAU - Paton, C
AU  - Paton C
AD  - National Institute for Health Innovation, University of Auckland, New Zealand.
      E-mail: c.paton@auckland.ac.nz.
FAU - Hansen, M
AU  - Hansen M
FAU - Fernandez-Luque, L
AU  - Fernandez-Luque L
FAU - Lau, A Y S
AU  - Lau AY
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Yearb Med Inform
JT  - Yearbook of medical informatics
JID - 9312666
SB  - IM
MH  - Chronic Disease
MH  - Electronic Health Records
MH  - Health Records, Personal
MH  - Humans
MH  - Medical Informatics
MH  - *Self Care
MH  - *Social Media/statistics & numerical data
EDAT- 2012/08/15 06:00
MHDA- 2016/04/23 06:00
CRDT- 2012/08/15 06:00
PHST- 2012/08/15 06:00 [entrez]
PHST- 2012/08/15 06:00 [pubmed]
PHST- 2016/04/23 06:00 [medline]
AID - me12010016 [pii]
PST - ppublish
SO  - Yearb Med Inform. 2012;7:16-24.


PMID- 22890333
OWN - NLM
STAT- MEDLINE
DCOM- 20160422
LR  - 20181201
IS  - 2364-0502 (Electronic)
IS  - 0943-4747 (Linking)
VI  - 7
DP  - 2012
TI  - Personal health informatics. Editorial.
PG  - 2-3
AB  - OBJECTIVES: To provide an editorial introduction to the 2012 IMIA Yearbook of
      Medical Informatics with an overview of its contents and contributors. METHODS: A
      brief overview of the main theme, and an outline of the purposes, contents,
      format, and acknowledgment of contributions for the 2012 IMIA Yearbook. RESULTS: 
      This 2012 issue of the IMIA Yearbook highlights important developments in
      personal health informatics, impacting the activities in research, education and 
      practice in this interdisciplinary field. There has been steady progress towards 
      introducing individualization or personalization into informatics systems by
      taking advantage of the increasing amounts of personal information that is
      relevant to medical decisions and application in clinical practice. At the same
      time, there are serious issues about the limits of existing systems being able to
      effectively personalize information within both practical and ethical constraints
      so critical to the practice of medicine. Recent literature bearing on these
      questions includes the selected papers published during the past 12 months, and
      articles reported by IMIA Working Groups on these topics. CONCLUSION: Surveys of 
      the main research sub-fields in biomedical informatics in the Yearbook provide an
      overview of progress and current challenges across the spectrum of the
      discipline, focusing on the challenges and opportunities involved in personal
      health informatics.
FAU - Kulikowski, C A
AU  - Kulikowski CA
AD  - Department of Computer Science, Rutgers-The State University of New Jersey, New
      Brunswick, NJ, USA.
FAU - Geissbuhler, A
AU  - Geissbuhler A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Yearb Med Inform
JT  - Yearbook of medical informatics
JID - 9312666
SB  - IM
MH  - Humans
MH  - *Medical Informatics
EDAT- 2012/08/15 06:00
MHDA- 2016/04/23 06:00
CRDT- 2012/08/15 06:00
PHST- 2012/08/15 06:00 [entrez]
PHST- 2012/08/15 06:00 [pubmed]
PHST- 2016/04/23 06:00 [medline]
AID - me12010002 [pii]
PST - ppublish
SO  - Yearb Med Inform. 2012;7:2-3.


PMID- 22890149
OWN - NLM
STAT- MEDLINE
DCOM- 20140124
LR  - 20130509
IS  - 1555-824X (Electronic)
IS  - 1062-8606 (Linking)
VI  - 28
IP  - 3
DP  - 2013 May-Jun
TI  - Do ophthalmology training programs affect corrective procedure rates after
      cataract surgery?
PG  - 250-5
LID - 10.1177/1062860612456069 [doi]
AB  - The Veterans Health Administration (VHA) plays a major role in training surgeons 
      in the United States. This study examined the rates of corrective procedures
      after routine cataract surgery stratified for VHA institutions according to the
      presence or absence of ophthalmology training programs. There was a wide range of
      rates of corrective surgeries in the 111 centers that performed cataract surgery.
      VHA medical centers affiliated with training programs had nearly twice the rates 
      of corrective surgery after cataract extraction than those institutions without
      such programs. Variation in secondary procedure rates has implications for the
      development of quality improvement in ophthalmology.
FAU - French, Dustin D
AU  - French DD
AD  - Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
      Dustin.French2@va.gov
FAU - Margo, Curtis E
AU  - Margo CE
FAU - Campbell, Robert R
AU  - Campbell RR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20120813
PL  - Netherlands
TA  - Am J Med Qual
JT  - American journal of medical quality : the official journal of the American
      College of Medical Quality
JID - 9300756
SB  - IM
MH  - Cataract Extraction/adverse effects/education/*standards
MH  - Hospitals, Veterans/organization & administration/standards/statistics &
      numerical data
MH  - Humans
MH  - Ophthalmology/*education
MH  - Patient Safety/standards/statistics & numerical data
MH  - Postoperative Complications/epidemiology
MH  - Reoperation/statistics & numerical data
MH  - United States
OTO - NOTNLM
OT  - ophthalmology medical ethics
OT  - patient safety
OT  - public health
OT  - quality
EDAT- 2012/08/15 06:00
MHDA- 2014/01/25 06:00
CRDT- 2012/08/15 06:00
PHST- 2012/08/15 06:00 [entrez]
PHST- 2012/08/15 06:00 [pubmed]
PHST- 2014/01/25 06:00 [medline]
AID - 1062860612456069 [pii]
AID - 10.1177/1062860612456069 [doi]
PST - ppublish
SO  - Am J Med Qual. 2013 May-Jun;28(3):250-5. doi: 10.1177/1062860612456069. Epub 2012
      Aug 13.


PMID- 22890064
OWN - NLM
STAT- MEDLINE
DCOM- 20130204
LR  - 20151119
IS  - 1531-698X (Electronic)
IS  - 1040-8703 (Linking)
VI  - 24
IP  - 5
DP  - 2012 Oct
TI  - Colorectal polyps in childhood.
PG  - 632-7
LID - 10.1097/MOP.0b013e328357419f [doi]
AB  - PURPOSE OF REVIEW: Colorectal polyps are a common cause of gastrointestinal
      bleeding in children. This review updates the information on colorectal polyps
      and summarizes the recent advances in genetics, diagnosis, and treatment of
      polyps in the large intestine. RECENT FINDINGS: A review of recent literature
      regarding colorectal polyps demonstrates an estimated detected prevalence of 6.1%
      overall and 12.0% among those with lower gastrointestinal bleeding during
      pediatric colonoscopy. Non-Caucasian races (e.g., black and Hispanic) are at
      higher risk for colorectal polyps in childhood. Recent data show juvenile polyps 
      may recur in approximately 45% of children with multiple polyps and 17% of
      children with solitary polyps. A clinical trial showed that celecoxib, a
      cyclooxygenase (COX)-2 inhibitor, significantly reduced the number of colorectal 
      polyps in children with familial adenomatous polyposis (FAP). Ethical challenges 
      related to genetic tests for FAP have been newly examined. The utility of novel
      endoscopic techniques (e.g., enteroscopy) in Peutz-Jeghers Syndrome to prevent
      intussusception have been newly described. SUMMARY: Although colorectal polyps in
      children are generally benign and easily removed, careful clinical evaluation and
      ongoing research are needed to identify the small proportion of children at risk 
      for cancer. The current paradigm of using the polyp number at presentation as a
      primary determinant of subsequent surveillance may be inadequate for many
      patients.
FAU - Thakkar, Kalpesh
AU  - Thakkar K
AD  - The Section of Pediatric Gastroenterology, Hepatology and Nutrition at Texas
      Children's Hospital, Baylor College of Medicine, Houston, Texas 77030, USA.
      kthakkar@bcm.tmc.edu
FAU - Fishman, Douglas S
AU  - Fishman DS
FAU - Gilger, Mark A
AU  - Gilger MA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Pediatr
JT  - Current opinion in pediatrics
JID - 9000850
RN  - 0 (Cyclooxygenase 2 Inhibitors)
RN  - 0 (Pyrazoles)
RN  - 0 (Sulfonamides)
RN  - JCX84Q7J1L (Celecoxib)
SB  - IM
MH  - *Adenomatous Polyps/complications/epidemiology/pathology
MH  - Adolescent
MH  - Age of Onset
MH  - Celecoxib
MH  - Child
MH  - Child, Preschool
MH  - *Colonic Polyps/complications/epidemiology/pathology
MH  - *Colorectal Neoplasms/epidemiology/pathology/prevention & control
MH  - Cyclooxygenase 2 Inhibitors/therapeutic use
MH  - Endoscopy, Gastrointestinal
MH  - Female
MH  - Gastrointestinal Hemorrhage/epidemiology/*etiology
MH  - Humans
MH  - Infant
MH  - Intestine, Large/*pathology
MH  - Intussusception/prevention & control
MH  - Male
MH  - *Peutz-Jeghers Syndrome/complications/epidemiology/pathology
MH  - Prevalence
MH  - Pyrazoles/therapeutic use
MH  - Sulfonamides/therapeutic use
EDAT- 2012/08/15 06:00
MHDA- 2013/02/05 06:00
CRDT- 2012/08/15 06:00
PHST- 2012/08/15 06:00 [entrez]
PHST- 2012/08/15 06:00 [pubmed]
PHST- 2013/02/05 06:00 [medline]
AID - 10.1097/MOP.0b013e328357419f [doi]
PST - ppublish
SO  - Curr Opin Pediatr. 2012 Oct;24(5):632-7. doi: 10.1097/MOP.0b013e328357419f.


PMID- 22889451
OWN - NLM
STAT- MEDLINE
DCOM- 20121226
LR  - 20191210
IS  - 1365-2702 (Electronic)
IS  - 0962-1067 (Linking)
VI  - 21
IP  - 17-18
DP  - 2012 Sep
TI  - Comparison of nurse practitioners' perceptions of required competencies and
      self-evaluated competencies in Taiwan.
PG  - 2679-89
LID - 10.1111/j.1365-2702.2012.04186.x [doi]
AB  - AIMS AND OBJECTIVES: This paper is a report of a study conducted to investigate
      differences between nurse practitioners' perceptions of the importance of
      required competencies and their self-evaluated existing competencies, and the
      main factors influencing these differences. BACKGROUND: The difference between
      nurse practitioners' perceptions of required competencies and their existing
      competencies has never been investigated. Therefore, it is still uncertain
      whether these two competencies differ. DESIGN: A nationwide survey study was
      authorised by the Department of Health (DOH) in Taiwan. METHODS: For this
      nationwide survey study, the Questionnaire of Competencies in the Nurse
      Practitioner's Role was mailed to all nurse practitioners who qualified for the
      first annual national NP licence exam in Taiwan. Of 582 questionnaires
      distributed, 374 valid questionnaires were returned for a response rate of 64.2%.
      RESULTS: The scores for required competencies were all higher than existing
      competencies. The competencies with largest differences were (in increasing
      order) clinical research, direct care, and leadership and reform. The
      competencies with smallest differences were (in ascending order) medical
      assistance, communication and coordination, and ethical decision-making.
      Differences in the total score between required and existing competencies were
      significantly influenced by nurse practitioners' age, seniority as nurse
      practitioner, whether the nurse practitioners' institution had a nurse
      practitioner advancement system, and the number of patients under their care.
      CONCLUSIONS: Nurse practitioners' perceptions of the importance of their expected
      role competencies were significantly greater in most cases than their actual
      competencies. RELEVANCE TO CLINICAL PRACTICE: These findings could serve as a
      reference to improve cultivation of the NP system in Taiwan, to strengthen
      professional competencies in NP training programs.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Chang, I-Wen
AU  - Chang IW
AD  - Cathay General Hospital, Taipei, Taiwan.
FAU - Shyu, Yea-Ing
AU  - Shyu YI
FAU - Tsay, Pei-Kwei
AU  - Tsay PK
FAU - Tang, Woung-Ru
AU  - Tang WR
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
PL  - England
TA  - J Clin Nurs
JT  - Journal of clinical nursing
JID - 9207302
MH  - Adult
MH  - Humans
MH  - Middle Aged
MH  - Nurse Practitioners/*psychology
MH  - Nursing Staff, Hospital/*psychology
MH  - *Professional Competence
MH  - Surveys and Questionnaires
MH  - Taiwan
EDAT- 2012/08/15 06:00
MHDA- 2012/12/27 06:00
CRDT- 2012/08/15 06:00
PHST- 2012/08/15 06:00 [entrez]
PHST- 2012/08/15 06:00 [pubmed]
PHST- 2012/12/27 06:00 [medline]
AID - 10.1111/j.1365-2702.2012.04186.x [doi]
PST - ppublish
SO  - J Clin Nurs. 2012 Sep;21(17-18):2679-89. doi: 10.1111/j.1365-2702.2012.04186.x.


PMID- 22889430
OWN - NLM
STAT- MEDLINE
DCOM- 20121107
LR  - 20220317
IS  - 1469-2910 (Electronic)
IS  - 1364-8470 (Linking)
VI  - 19
IP  - 2
DP  - 2012
TI  - Reproductive governance in Latin America.
PG  - 241-54
LID - 10.1080/13648470.2012.675046 [doi]
AB  - This paper develops the concept of reproductive governance as an analytic tool
      for tracing the shifting political rationalities of population and reproduction. 
      As advanced here, the concept of reproductive governance refers to the mechanisms
      through which different historical configurations of actors - such as state,
      religious, and international financial institutions, NGOs, and social movements -
      use legislative controls, economic inducements, moral injunctions, direct
      coercion, and ethical incitements to produce, monitor, and control reproductive
      behaviours and population practices. Examples are drawn from Latin America, where
      reproductive governance is undergoing a dramatic transformation as public policy 
      conversations are coalescing around new moral regimes and rights-based actors
      through debates about abortion, emergency contraception, sterilisation,
      migration, and assisted reproductive technologies. Reproductive discourses are
      increasingly framed through morality and contestations over 'rights', where
      rights-bearing citizens are pitted against each other in claiming reproductive,
      sexual, indigenous, and natural rights, as well as the 'right to life' of the
      unborn. The concept of reproductive governance can be applied to other settings
      in order to understand shifting political rationalities within the domain of
      reproduction.
FAU - Morgan, Lynn M
AU  - Morgan LM
AD  - Department of Sociology and Anthropology, Mount Holyoke College, South Hadley,
      MA, USA. lmmorgan@mtholyoke.edu
FAU - Roberts, Elizabeth F S
AU  - Roberts EF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Anthropol Med
JT  - Anthropology & medicine
JID - 9709920
SB  - IM
MH  - Abortion, Induced
MH  - Catholicism
MH  - Contraception
MH  - *Government
MH  - *Human Rights
MH  - Humans
MH  - Latin America
MH  - Morals
MH  - *Politics
MH  - *Public Policy
MH  - *Reproductive Behavior
MH  - Socioeconomic Factors
EDAT- 2012/08/15 06:00
MHDA- 2012/11/08 06:00
CRDT- 2012/08/15 06:00
PHST- 2012/08/15 06:00 [entrez]
PHST- 2012/08/15 06:00 [pubmed]
PHST- 2012/11/08 06:00 [medline]
AID - 10.1080/13648470.2012.675046 [doi]
PST - ppublish
SO  - Anthropol Med. 2012;19(2):241-54. doi: 10.1080/13648470.2012.675046.


PMID- 22889188
OWN - NLM
STAT- MEDLINE
DCOM- 20131203
LR  - 20130115
IS  - 1440-1800 (Electronic)
IS  - 1320-7881 (Linking)
VI  - 20
IP  - 1
DP  - 2013 Mar
TI  - Nursings' need for the idea of spirituality.
PG  - 5-10
LID - 10.1111/j.1440-1800.2012.00608.x [doi]
AB  - Spirituality is an idea that has sustained significant interest in nursing over
      the past quarter century. Extensive conceptual work has generated robust critique
      around clarity and professional jurisdictional claims. However, less attention
      has been paid to the challenges nursing has faced that have contributed to the
      spirituality quest. Reflecting on my own experiences as a scholar writing in this
      literature over the past decade, I suggest three challenges that spirituality has
      attempted to redress: to relate across difference in a globalized world, to be
      good in a world of uncertain morality and to find meaning in a disenchanted
      world. The idea of spirituality could be viewed as resistance against othering,
      against law based ethics, and against politics and power. But the impact of the
      idea of spirituality has yet to be determined and caution is in order. As
      important as this resistance is, nursing must refrain from creating a new world
      of insiders and outsiders and from minimizing the role of religious ethics in a
      globalized world. Spirituality, like its predecessor religion, will likely
      continue to play an enduring role in providing fundamental meaning for nursing
      work.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Pesut, Barbara
AU  - Pesut B
AD  - School of Nursing, Canada Research Chair, Health, Ethics and Diversity,
      University of British Columbia, Kelowna, BC, Canada. barb.pesut@ubc.ca
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120814
PL  - Australia
TA  - Nurs Inq
JT  - Nursing inquiry
JID - 9505881
MH  - Cultural Diversity
MH  - Humans
MH  - Morals
MH  - *Philosophy, Nursing
MH  - Religion and Medicine
MH  - *Spirituality
EDAT- 2012/08/15 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/08/15 06:00
PHST- 2012/08/15 06:00 [entrez]
PHST- 2012/08/15 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1111/j.1440-1800.2012.00608.x [doi]
PST - ppublish
SO  - Nurs Inq. 2013 Mar;20(1):5-10. doi: 10.1111/j.1440-1800.2012.00608.x. Epub 2012
      Aug 14.


PMID- 22889162
OWN - NLM
STAT- MEDLINE
DCOM- 20131219
LR  - 20130430
IS  - 1939-2222 (Electronic)
IS  - 0022-1015 (Linking)
VI  - 142
IP  - 2
DP  - 2013 May
TI  - Listen to your heart: when false somatic feedback shapes moral behavior.
PG  - 307-12
LID - 10.1037/a0029549 [doi]
AB  - A pounding heart is a common symptom people experience when confronting moral
      dilemmas. The authors conducted 4 experiments using a false feedback paradigm to 
      explore whether and when listening to a fast (vs. normal) heartbeat sound shaped 
      ethical behavior. Study 1 found that perceived fast heartbeat increased
      volunteering for a just cause. Study 2 extended this effect to moral
      transgressions and showed that perceived fast heartbeat reduced lying for
      self-gain. Studies 3 and 4 explored the boundary conditions of this effect and
      found that perceived heartbeat had less influence on deception when people are
      mindful or approach the decision deliberatively. These findings suggest that the 
      perceived physiological experience of fast heartbeats may signal greater distress
      in moral situations and hence motivate people to take the moral high road.
CI  - PsycINFO Database Record (c) 2013 APA, all rights reserved.
FAU - Gu, Jun
AU  - Gu J
AD  - School of Business, University of British Columbia, Vancouver, British Columbia, 
      Canada. J.Gu@Monash.edu
FAU - Zhong, Chen-Bo
AU  - Zhong CB
FAU - Page-Gould, Elizabeth
AU  - Page-Gould E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120813
PL  - United States
TA  - J Exp Psychol Gen
JT  - Journal of experimental psychology. General
JID - 7502587
SB  - IM
MH  - Adaptation, Psychological
MH  - Adolescent
MH  - Adult
MH  - Autonomic Nervous System/*physiology
MH  - Deception
MH  - Feedback, Physiological/*physiology
MH  - Female
MH  - Heart Rate/*physiology
MH  - Humans
MH  - Male
MH  - Morals
MH  - *Motivation
MH  - Stress, Psychological/physiopathology
EDAT- 2012/08/15 06:00
MHDA- 2013/12/20 06:00
CRDT- 2012/08/15 06:00
PHST- 2012/08/15 06:00 [entrez]
PHST- 2012/08/15 06:00 [pubmed]
PHST- 2013/12/20 06:00 [medline]
AID - 2012-21306-001 [pii]
AID - 10.1037/a0029549 [doi]
PST - ppublish
SO  - J Exp Psychol Gen. 2013 May;142(2):307-12. doi: 10.1037/a0029549. Epub 2012 Aug
      13.


PMID- 22888470
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 2150-7716 (Print)
IS  - 2150-7724 (Linking)
VI  - 3
IP  - 3
DP  - 2012 Jan 1
TI  - Funding and Forums for ELSI Research: Who (or What) is Setting the Agenda?
PG  - 51-60
AB  - BACKGROUND: Discussion of the influence of money on bioethics research seems
      particularly salient in the context of research on the ethical, legal and social 
      implications (ELSI) of human genomics, as this research may be financially
      supported by the ELSI Research Program. Empirical evidence regarding the funding 
      of ELSI research and where such research is disseminated, in relation to the
      specific topics of the research and methods used, can help to further discussions
      regarding the appropriate influence of specific institutions and institutional
      contexts on ELSI and other bioethics research agendas. METHODS: We reviewed 642
      ELSI publications (appearing between 2003-2008) for reported sources of funding, 
      forum for dissemination, empirical and non-empirical methods, and topic of
      investigation. RESULTS: Most ELSI research is independent of direct grant-based
      funding sources; 66% reported no such sources of funding. The National Human
      Genome Research Institute (NHGRI) is the most dominant source of funding; 16% of 
      publications acknowledged at least one source of NHGRI grant funding. Funding is 
      acknowledged more frequently in empirical than non-empirical publications, and
      more frequently in publications in public health journals than in any other ELSI 
      research dissemination forums. Dominant research topics vary by publication forum
      and by reported funding. CONCLUSIONS: ELSI research is surprisingly independent
      of direct grant-based funding, yet correlations are apparent between this type of
      funding and publication placement, topics addressed, and methods used, implying a
      not insignificant influence on ELSI research agenda-setting. However, given the
      relatively low percentage of publications acknowledging external grant-based
      funding, as well as other significant correlations between publication placement 
      and topics addressed, additional institutional contexts, perhaps related to
      professional advancement or valuation, may shape research agendas in ways that
      potentially exceed the direct influences of grant-based funding in this area. In 
      some cases, grant-based funding may actually counter other potentially
      problematic institutional influences.
FAU - Morrissey, Clair
AU  - Morrissey C
AD  - Occidental College.
FAU - Walker, Rebecca L
AU  - Walker RL
LA  - eng
GR  - P50 HG004488/HG/NHGRI NIH HHS/United States
PT  - Journal Article
DEP - 20120619
PL  - United States
TA  - AJOB Prim Res
JT  - AJOB primary research
JID - 101520734
PMC - PMC3413296
MID - NIHMS387328
EDAT- 2012/08/14 06:00
MHDA- 2012/08/14 06:01
CRDT- 2012/08/14 06:00
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2012/08/14 06:01 [medline]
AID - 10.1080/21507716.2012.678550 [doi]
PST - ppublish
SO  - AJOB Prim Res. 2012 Jan 1;3(3):51-60. doi: 10.1080/21507716.2012.678550. Epub
      2012 Jun 19.


PMID- 22888362
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20220311
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2012
DP  - 2012
TI  - Earthworms dilong: ancient, inexpensive, noncontroversial models may help clarify
      approaches to integrated medicine emphasizing neuroimmune systems.
PG  - 164152
LID - 10.1155/2012/164152 [doi]
AB  - Earthworms have provided ancient cultures with food and sources of medicinal
      cures. Ayurveda, traditional Chinese medicine (TCM), and practices in Japan,
      Vietnam, and Korea have focused first on earthworms as sources of food. Gradually
      fostering an approach to potential beneficial healing properties, there are
      renewed efforts through bioprospecting and evidence-based research to understand 
      by means of rigorous investigations the mechanisms of action whether earthworms
      are used as food and/or as sources of potential medicinal products. Focusing on
      earthworms grew by serendipity from an extensive analysis of the earthworm's
      innate immune system. Their immune systems are replete with leukocytes and
      humoral products that exert credible health benefits. Their emerging functions
      with respect to evolution of innate immunity have long been superseded by their
      well-known ecological role in soil conservation. Earthworms as inexpensive,
      noncontroversial animal models (without ethical concerns) are not vectors of
      disease do not harbor parasites that threaten humans nor are they annoying pests.
      By recognizing their numerous ecological, environmental, and biomedical roles,
      substantiated by inexpensive and more comprehensive investigations, we will
      become more aware of their undiscovered beneficial properties.
FAU - Cooper, Edwin L
AU  - Cooper EL
AD  - Graduate Institute of Basic Medical Science, China Medical University, Taichung
      40402, Taiwan.
FAU - Balamurugan, Mariappan
AU  - Balamurugan M
FAU - Huang, Chih-Yang
AU  - Huang CY
FAU - Tsao, Clara R
AU  - Tsao CR
FAU - Heredia, Jesus
AU  - Heredia J
FAU - Tommaseo-Ponzetta, Mila
AU  - Tommaseo-Ponzetta M
FAU - Paoletti, Maurizio G
AU  - Paoletti MG
LA  - eng
PT  - Journal Article
DEP - 20120725
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC3410320
EDAT- 2012/08/14 06:00
MHDA- 2012/08/14 06:01
CRDT- 2012/08/14 06:00
PHST- 2011/12/09 00:00 [received]
PHST- 2012/03/20 00:00 [revised]
PHST- 2012/04/01 00:00 [accepted]
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2012/08/14 06:01 [medline]
AID - 10.1155/2012/164152 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2012;2012:164152. doi: 10.1155/2012/164152.
      Epub 2012 Jul 25.


PMID- 22888265
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1178-6981 (Electronic)
IS  - 1178-6981 (Linking)
VI  - 4
DP  - 2012
TI  - New strategies for lowering the costs of antiretroviral treatment and care for
      people with HIV/AIDS in the United Kingdom.
PG  - 193-200
LID - 10.2147/CEOR.S12496 [doi]
AB  - In the UK, the annual cost of treatment and care for people with human
      immunodeficiency virus (HIV)/acquired immune deficiency virus (AIDS) rose by over
      600% from pound104 million in 1997 to pound762 million in 2010; approximately
      two-thirds of the pound762 million cost of treatment and care in 2010 was for the
      procurement of antiretrovirals and other related drugs. The number of people
      accessing care for HIV/AIDS rose from 22,000 in 2000 to 65,000 in 2009. Adoption 
      of "test and treat" guidelines for treating all HIV-infected people with
      antiretrovirals would further increase the burden of costs. Given the current
      economic situation, there is now a new focus on strategies for treatment and care
      of people with HIV-1 infection which can maintain efficacy but at a lower cost.
      In this review, we propose three strategies which could potentially lower the
      costs of treatment and care, ie, stopping testing CD4 counts for patients with
      full HIV RNA suppression on antiretroviral treatment and recent CD4 counts above 
      350 cells/muL; more widespread use of generic antiretrovirals as replacements for
      patients currently taking patented versions; and use of darunavir-ritonavir
      monotherapy as a switch option for patients with full HIV RNA suppression on
      other antiretrovirals and no history of virological failure. However, it is
      important that high standards of clinical care are maintained despite cost-saving
      measures. Antiretrovirals with generic alternatives may have toxicity issues, eg,
      zidovudine and nevirapine. There could be ethical issues in starting patients on 
      these drugs if they are currently tolerating other treatments. The use of
      darunavir-ritonavir monotherapy is not consistently recommended in international 
      HIV treatment guidelines.
FAU - Gazzard, Brian
AU  - Gazzard B
AD  - St Stephens Centre, Chelsea and Westminster Hospital, London, UK.
FAU - Moecklinghoff, Christiane
AU  - Moecklinghoff C
FAU - Hill, Andrew
AU  - Hill A
LA  - eng
PT  - Journal Article
DEP - 20120712
PL  - New Zealand
TA  - Clinicoecon Outcomes Res
JT  - ClinicoEconomics and outcomes research : CEOR
JID - 101560564
PMC - PMC3414377
OTO - NOTNLM
OT  - darunavir-ritonavir monotherapy
OT  - generics
OT  - health economics
OT  - non-nucleoside reverse transcriptase inhibitors
OT  - nucleoside analogs
EDAT- 2012/08/14 06:00
MHDA- 2012/08/14 06:01
CRDT- 2012/08/14 06:00
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2012/08/14 06:01 [medline]
AID - 10.2147/CEOR.S12496 [doi]
AID - ceor-4-193 [pii]
PST - ppublish
SO  - Clinicoecon Outcomes Res. 2012;4:193-200. doi: 10.2147/CEOR.S12496. Epub 2012 Jul
      12.


PMID- 22888256
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1178-203X (Electronic)
IS  - 1176-6336 (Linking)
VI  - 8
DP  - 2012
TI  - Training in peroral endoscopic myotomy (POEM) for esophageal achalasia.
PG  - 329-42
LID - 10.2147/TCRM.S32666 [doi]
AB  - Peroral endoscopic myotomy (POEM) has been developed in the context of natural
      orifice transluminal endoscopic surgery (NOTES) as a minimally invasive
      endoscopic treatment for symptomatic esophageal achalasia, which is a chronic
      progressive benign disease with severe morbidity and difficult management. Since 
      September 2008, POEM has been successfully performed in more than 200 consecutive
      patients with symptomatic achalasia at the Digestive Disease Center of Showa
      University, Northern Yokohama Hospital, Yokohama, Japan, with excellent short-
      and long-term results and absence of serious complications. International
      experience of POEM within clinical studies is also promising. According to these 
      results, POEM is considered as a safe procedure that can be applied to all
      achalasia patients. However, the low incidence of achalasia (0.3%-1% per 100,000 
      population), in combination with the potential serious complications related to
      the technically demanding POEM procedure, has made training difficult. There is
      therefore an urgent need for an animal model for training to decrease the
      learning curve. Further, there are other ethical and training issues to address. 
      The pig is the most appropriate animal model for training in POEM due to its
      anatomy being similar to that of humans. The porcine esophagus has the advantage 
      of easy mobilization due to absence of tight junctions to surrounding organs. A
      non-survival porcine model would be a simple, inexpensive, and reproducible
      animal model for training in POEM, without the need for concern about
      complications. A possible training process might first involve observation of
      POEM performed by specialists, then training on non-survival and survival porcine
      models, followed by training in humans under specialist guidance and finally,
      performance of POEM in humans.
FAU - Eleftheriadis, Nicholas
AU  - Eleftheriadis N
AD  - Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, 
      Japan.
FAU - Inoue, Haruhiro
AU  - Inoue H
FAU - Ikeda, Haruo
AU  - Ikeda H
FAU - Onimaru, Manabu
AU  - Onimaru M
FAU - Yoshida, Akira
AU  - Yoshida A
FAU - Hosoya, Toshihisa
AU  - Hosoya T
FAU - Maselli, Roberta
AU  - Maselli R
FAU - Kudo, Shin-Ei
AU  - Kudo SE
LA  - eng
PT  - Journal Article
DEP - 20120723
PL  - New Zealand
TA  - Ther Clin Risk Manag
JT  - Therapeutics and clinical risk management
JID - 101253281
PMC - PMC3414088
OTO - NOTNLM
OT  - Heller myotomy
OT  - non-survival
OT  - porcine esophagus
OT  - porcine organ model
EDAT- 2012/08/14 06:00
MHDA- 2012/08/14 06:01
CRDT- 2012/08/14 06:00
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2012/08/14 06:01 [medline]
AID - 10.2147/TCRM.S32666 [doi]
AID - tcrm-8-329 [pii]
PST - ppublish
SO  - Ther Clin Risk Manag. 2012;8:329-42. doi: 10.2147/TCRM.S32666. Epub 2012 Jul 23.


PMID- 22888170
OWN - NLM
STAT- MEDLINE
DCOM- 20130211
LR  - 20120917
IS  - 1460-2350 (Electronic)
IS  - 0268-1161 (Linking)
VI  - 27
IP  - 10
DP  - 2012 Oct
TI  - Sperm and oocyte cryopreservation: comprehensive consent and the protection of
      patient autonomy.
PG  - 2894-8
LID - 10.1093/humrep/des290 [doi]
AB  - Sperm cryopreservation and increasingly oocyte cryopreservation are common forms 
      of fertility preservation for oncology patients facing gonadotoxic therapy. Both 
      procedures present challenging ethical issues with regard to informed consent,
      given that the context for these procedures is a disease that carries a
      significant risk of mortality. We argue that the current consent process does not
      allow for adequate collection of information about a patient's wishes for the
      custody of cryopreserved gametes in the case of premature death. After review of 
      the European Society of Human Reproduction and Embryology and the American
      Society of Reproductive Medicine guidelines we propose that a new, comprehensive 
      consent procedure for sperm and oocyte cryopreservation including a 'roll-down'
      option is imperative to protect the autonomy of these oncology patients. This
      'roll-down' option should allow for the transfer of custody of gametes to a
      pre-selected alternative recipient(s) if the original recipient no longer intends
      to use the gametes to create a child. We also demonstrate that objections over
      non-spousal custody of gametes can be overcome with sound ethical arguments.
FAU - Dillon, Katherine E
AU  - Dillon KE
AD  - Department of Obstetrics and Gynecology, University of Pennsylvania,
      Philadelphia, PA 19104, USA.
FAU - Fiester, Autumn M
AU  - Fiester AM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120811
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
SB  - IM
MH  - Cryopreservation/*ethics
MH  - Female
MH  - Fertility Preservation/ethics/methods
MH  - Guidelines as Topic
MH  - Humans
MH  - Informed Consent
MH  - Male
MH  - *Oocytes
MH  - *Personal Autonomy
MH  - *Spermatozoa
EDAT- 2012/08/14 06:00
MHDA- 2013/02/12 06:00
CRDT- 2012/08/14 06:00
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2013/02/12 06:00 [medline]
AID - des290 [pii]
AID - 10.1093/humrep/des290 [doi]
PST - ppublish
SO  - Hum Reprod. 2012 Oct;27(10):2894-8. doi: 10.1093/humrep/des290. Epub 2012 Aug 11.


PMID- 22888151
OWN - NLM
STAT- MEDLINE
DCOM- 20130104
LR  - 20181201
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 10
DP  - 2012 Oct
TI  - Neuroenhancers, addiction and research ethics.
PG  - 605-8
AB  - In their recent paper in this journal, Heinz and colleagues accuse proponents of 
      cognitive enhancement of making two unjustified assumptions. The first of these
      is the assumption that neuroenhancing drugs will be safe; the second is that
      research into cognitive enhancement does not pose particular ethical problems.
      Heinz and colleagues argue that both these assumptions are false. Here, I argue
      that these assumptions are in fact correct, and that Heinz and colleagues
      themselves make several assumptions that undermine their argument.
      Neuroenhancement does raise several ethical concerns, but safety and research in 
      this area pose no unique difficulties.
FAU - Shaw, David Martin
AU  - Shaw DM
AD  - Institute for Biomedical Ethics, University of Basel, Missionsstrasse 24, CH-4055
      Basel, Basel-Stadt, Switzerland. davidmartinshaw@gmail.com
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20120811
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
RN  - 0 (Central Nervous System Stimulants)
SB  - IM
CON - J Med Ethics. 2012 Jun;38(6):372-5. PMID: 22228818
CIN - J Med Ethics. 2014 Apr;40(4):286-7. PMID: 23468510
MH  - Behavior, Addictive/*chemically induced
MH  - Biomedical Enhancement/*ethics
MH  - Central Nervous System Stimulants/*adverse effects
MH  - Cognition/*drug effects
MH  - Humans
MH  - Substance-Related Disorders/*etiology
EDAT- 2012/08/14 06:00
MHDA- 2013/01/05 06:00
CRDT- 2012/08/14 06:00
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2013/01/05 06:00 [medline]
AID - medethics-2012-100616 [pii]
AID - 10.1136/medethics-2012-100616 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Oct;38(10):605-8. doi: 10.1136/medethics-2012-100616. Epub
      2012 Aug 11.


PMID- 22886155
OWN - NLM
STAT- MEDLINE
DCOM- 20130208
LR  - 20211021
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 24
IP  - 3
DP  - 2012 Sep
TI  - 500 hats: exploring the challenges of boundary and community--reflections on
      professionalization.
PG  - 171-8
LID - 10.1007/s10730-012-9190-0 [doi]
AB  - I argue that it is possible to reframe the current debates over
      professionalization in a way that can account for disagreement without insisting 
      that its advocates and opponents are adversaries. Giles Scofield, and critics
      like him, may be understood as engaging in the sort of theoretical disagreement
      that is an inescapable and vital part of our practice. The field could profit
      from the work of legal theorist Ronald Dworkin who has long argued that people of
      good will and great competence need not share foundational assumptions. They may,
      instead, be advancing rival interpretations of what the practice of healthcare
      ethics (PHE) requires.
FAU - Heesters, Ann
AU  - Heesters A
AD  - University Health Network, Toronto Rehabilitation Institute/UHN, University
      Centre, Toronto, ON, Canada. Ann.heesters@uhn.ca
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - *Bioethics
MH  - Ethicists/standards
MH  - Humans
MH  - *Professional Competence
MH  - Professional Practice
MH  - *Professional Role
EDAT- 2012/08/14 06:00
MHDA- 2013/02/09 06:00
CRDT- 2012/08/14 06:00
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2013/02/09 06:00 [medline]
AID - 10.1007/s10730-012-9190-0 [doi]
PST - ppublish
SO  - HEC Forum. 2012 Sep;24(3):171-8. doi: 10.1007/s10730-012-9190-0.


PMID- 22886154
OWN - NLM
STAT- MEDLINE
DCOM- 20130208
LR  - 20211021
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 24
IP  - 3
DP  - 2012 Sep
TI  - Deliberative engagement: an inclusive methodology for exploring
      professionalization.
PG  - 187-201
LID - 10.1007/s10730-012-9189-6 [doi]
AB  - Early on in the development of Practicing Healthcare Ethicists Exploring
      Professionalization (PHEEP), the founding members recognized the need to address 
      and meet two important goals: (1) the creation of a dynamic, rigorous process to 
      support the exploratory work, and (2) the establishment of the
      means--deliberative engagement--to generate and justify the substantive content
      of professionalization-related products, such as practice standards and position 
      statements. Drawing from social justice and deliberative democracy conceptions
      and insights (among others), the authors identify and describe the core elements 
      of the "process scaffolding" and "deliberative means" that inform PHEEP's
      deliberative engagement methodology. The paper demonstrates how these process and
      substantive features have been meaningfully instantiated in the decision making
      framework established by PHEEP for its use in the development of
      professionalization-related products by Canadian practicing healthcare ethicists.
FAU - Kirby, Jeffrey
AU  - Kirby J
AD  - Department of Bioethics, Faculty of Medicine, Dalhousie University, Halifax, NS, 
      Canada. Jeffrey.kirby@dal.ca
FAU - Simpson, Christy
AU  - Simpson C
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - *Bioethics
MH  - Canada
MH  - *Cooperative Behavior
MH  - Decision Making
MH  - Ethicists/standards
MH  - Humans
MH  - *Professional Competence
MH  - *Professional Role
MH  - Program Development
EDAT- 2012/08/14 06:00
MHDA- 2013/02/09 06:00
CRDT- 2012/08/14 06:00
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2013/02/09 06:00 [medline]
AID - 10.1007/s10730-012-9189-6 [doi]
PST - ppublish
SO  - HEC Forum. 2012 Sep;24(3):187-201. doi: 10.1007/s10730-012-9189-6.


PMID- 22886153
OWN - NLM
STAT- MEDLINE
DCOM- 20130208
LR  - 20211021
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 24
IP  - 3
DP  - 2012 Sep
TI  - Mapping our practice? Some conceptual "bumps" for us to consider.
PG  - 219-26
LID - 10.1007/s10730-012-9188-7 [doi]
AB  - There are several important conceptual issues and questions about the practice of
      healthcare ethics that can, and should, inform the development of any practice
      standards. This paper provides a relatively short overview of seven of these
      issues, with the invitation for further critical reflection and examination of
      their relevance to and implications for practice standards. The seven issues
      described include: diversity (from the perspective of training and experience);
      moral expertise and authority/influence; being an insider or outsider;
      flexibility and adaptability (for local contexts of practice); the relative
      weighting of procedural and normative aspects of ethics practice; making mistakes
      or errors; and conflicts of interest in practice.
FAU - Simpson, Christy
AU  - Simpson C
AD  - Department of Bioethics, Faculty of Medicine, Dalhousie University, Halifax, NS, 
      Canada. Christy.simpson@Dal.ca
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - Canada
MH  - *Concept Formation
MH  - Conflict of Interest
MH  - Delivery of Health Care/*ethics
MH  - Ethicists
MH  - Humans
MH  - Medical Errors/ethics
MH  - Moral Obligations
MH  - Professional Practice/*standards
EDAT- 2012/08/14 06:00
MHDA- 2013/02/09 06:00
CRDT- 2012/08/14 06:00
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2013/02/09 06:00 [medline]
AID - 10.1007/s10730-012-9188-7 [doi]
PST - ppublish
SO  - HEC Forum. 2012 Sep;24(3):219-26. doi: 10.1007/s10730-012-9188-7.


PMID- 22886120
OWN - NLM
STAT- MEDLINE
DCOM- 20151027
LR  - 20191210
IS  - 0379-5284 (Print)
IS  - 0379-5284 (Linking)
VI  - 33
IP  - 8
DP  - 2012 Aug
TI  - Linguistic and clinical validation of the Arabic-translated Aberdeen Menorrhagia 
      Severity Scale as an indicator of quality of life for women with abnormal uterine
      bleeding.
PG  - 869-74
AB  - OBJECTIVES: To develop a conceptually and semantically valid Arabic version of a 
      validated disease-specific instrument of quality of life (QoL) for women with
      abnormal uterine bleeding (AUB). METHODS: This is a prospective cohort study
      conducted at the Department of Obstetrics & Gynecology, King Saud University,
      Riyadh, Kingdom of Saudi Arabia between December 2010 and December 2011 following
      ethics approval. Forward translation of the Aberdeen Menorrhagia Severity Scale
      (AMSS) from English into Arabic was followed by backward translation of the
      consensus target (Arabic) version into the source (English) language.
      Subsequently, a final target (Arabic) language version was created. Sixty-one
      Arabic-speaking women of reproductive age participated in the study. The final
      Arabic questionnaire was administered to 41 women with self-perceived normal
      menses (Group 1) on 2 occasions 2 weeks apart. Agreement in the answers deems the
      questionnaire reliable. The final Arabic version was administered to 20 women
      with self-perceived AUB (Group 2), and their scores were compared with the first 
      response of Group 1. A significant difference between the groups deems the
      questionnaire valid. RESULTS: For linguistic validation; intra-class correlation 
      coefficient (ICC) of 0.87 and Kappa statistics of 0.56 to 0.87 indicated good to 
      excellent agreement. For clinical validation, there was a significant difference 
      between Group 1 and 2 (p=0.001). CONCLUSION: The translated Arabic AMSS is a
      reliable and valid indicator of QoL in Saudi women with AUB.
FAU - Abu-Rafea, Basim F
AU  - Abu-Rafea BF
AD  - Obstetrics and Gynecology, King Khalid University Hospital, PO Box 7805, Riyadh
      11472, Kingdom of Saudi Arabia. Tel. +966 (1) 4670818. Fax. +966 (1) 4679557.
      E-mail: baburafea@ksu.edu.sa.
FAU - Vilos, George A
AU  - Vilos GA
FAU - Al Jasser, Rakia S
AU  - Al Jasser RS
FAU - Al Anazy, Reem M
AU  - Al Anazy RM
FAU - Javaid, Khalida
AU  - Javaid K
FAU - Al-Mandeel, Hazem M
AU  - Al-Mandeel HM
LA  - eng
PT  - Journal Article
PT  - Validation Study
PL  - Saudi Arabia
TA  - Saudi Med J
JT  - Saudi medical journal
JID - 7909441
SB  - IM
MH  - Adult
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Menorrhagia/*diagnosis
MH  - Metrorrhagia/*diagnosis
MH  - Prospective Studies
MH  - *Quality of Life
MH  - Severity of Illness Index
MH  - Surveys and Questionnaires
MH  - *Translations
MH  - Young Adult
EDAT- 2012/08/14 06:00
MHDA- 2015/10/28 06:00
CRDT- 2012/08/14 06:00
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2015/10/28 06:00 [medline]
AID - 20120287' [pii]
PST - ppublish
SO  - Saudi Med J. 2012 Aug;33(8):869-74.


PMID- 22885181
OWN - NLM
STAT- MEDLINE
DCOM- 20130118
LR  - 20120910
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 425
IP  - 4
DP  - 2012 Sep 7
TI  - Genetic analysis of the SIRT1 gene promoter in ventricular septal defects.
PG  - 741-5
LID - 10.1016/j.bbrc.2012.07.145 [doi]
AB  - Mutations in cardiac transcription factor genes, such as GATA-4, NKX2-5 and TBX5 
      genes, have been associated to the patients with familial and isolated congenital
      heart disease (CHD). Little work has been done on the epigenetic causes for CHD. 
      Sirtuis are highly conserved NAD-dependent class III deacetylases. In mammals,
      there are seven members of surtuin family, SIRT1-SIRT7. SIRT1, the closest to
      yeast Sir2, has deacetylase activity and ADP-ribosyltransferase activity. SIRT1
      has been involved in many cellular processes and implicated in human diseases,
      such as obesity, type 2 diabetes, cancer and neurodegenerative diseases. We
      hypothesized that altered levels of SIRT1 gene expression, rather than mutations 
      in SIRT1 gene, may contribute to the human diseases. In this study, we
      genetically analyze the SIRT1 gene promoter in patients with ventricular septal
      defects (VSD) (n=333) and ethic-matched healthy controls (n=348). In all, six
      single-nucleotide polymorphisms (SNPs) and twelve heterozygous sequence variants 
      were identified. Four novel heterozygous variants, g.69643693A>G, g.69643963A>T, 
      g.69643971G>A and g.69644366Ins, were found in six VSD patients, but in none of
      controls. Six SNPs and variants, g.69643707A>C (rs35706870), g.69643874C>A,
      g.69644209C>G, g.69644213G>A, g.69644268T>A and g.69644441G>A, were only
      identified in controls. The other SNPs and variants were found in both groups
      with similar frequencies. Therefore, the variants within the SIRT1 gene promoter 
      identified in VSD patients may alter the transcriptional activities of SIRT1 gene
      promoter. Changed SIRT1 protein levels may contribute to the VSD etiology by
      affecting the activities of its substrates.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Shan, Jiping
AU  - Shan J
AD  - Shandong Provincial Key Laboratory of Cardiac Disease Diagnosis and Treatment,
      Jining Medical University Affiliated Hospital, Jining Medical University, Jining,
      Shandong 272029, PR China.
FAU - Pang, Shuchao
AU  - Pang S
FAU - Wanyan, Hongxin
AU  - Wanyan H
FAU - Xie, Wen
AU  - Xie W
FAU - Qin, Xianyun
AU  - Qin X
FAU - Yan, Bo
AU  - Yan B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120803
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - EC 3.5.1.- (SIRT1 protein, human)
RN  - EC 3.5.1.- (Sirtuin 1)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - China/epidemiology
MH  - DNA Mutational Analysis
MH  - Female
MH  - Heart Septal Defects, Ventricular/embryology/*genetics
MH  - Heterozygote
MH  - Humans
MH  - Infant
MH  - Male
MH  - Promoter Regions, Genetic/*genetics
MH  - Sirtuin 1/*genetics
MH  - Young Adult
EDAT- 2012/08/14 06:00
MHDA- 2013/01/19 06:00
CRDT- 2012/08/14 06:00
PHST- 2012/07/17 00:00 [received]
PHST- 2012/07/26 00:00 [accepted]
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2013/01/19 06:00 [medline]
AID - S0006-291X(12)01459-3 [pii]
AID - 10.1016/j.bbrc.2012.07.145 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2012 Sep 7;425(4):741-5. doi:
      10.1016/j.bbrc.2012.07.145. Epub 2012 Aug 3.


PMID- 22884938
OWN - NLM
STAT- MEDLINE
DCOM- 20130701
LR  - 20130114
IS  - 1873-5134 (Electronic)
IS  - 0738-3991 (Linking)
VI  - 90
IP  - 2
DP  - 2013 Feb
TI  - Whole mind and shared mind in clinical decision-making.
PG  - 200-6
LID - 10.1016/j.pec.2012.06.035 [doi]
LID - S0738-3991(12)00294-7 [pii]
AB  - OBJECTIVE: To review the theory, research evidence and ethical implications
      regarding "whole mind" and "shared mind" in clinical practice in the context of
      chronic and serious illnesses. METHODS: Selective critical review of the
      intersection of classical and naturalistic decision-making theories, cognitive
      neuroscience, communication research and ethics as they apply to decision-making 
      and autonomy. RESULTS: Decision-making involves analytic thinking as well as
      affect and intuition ("whole mind") and sharing cognitive and affective schemas
      of two or more individuals ("shared mind"). Social relationships can help
      processing of complex information that otherwise would overwhelm individuals'
      cognitive capacities. CONCLUSIONS: Medical decision-making research, teaching and
      practice should consider both analytic and non-analytic cognitive processes.
      Further, research should consider that decisions emerge not only from the
      individual perspectives of patients, their families and clinicians, but also the 
      perspectives that emerge from the interactions among them. Social interactions
      have the potential to enhance individual autonomy, as well as to promote
      relational autonomy based on shared frames of reference. PRACTICE IMPLICATIONS:
      Shared mind has the potential to result in wiser decisions, greater autonomy and 
      self-determination; yet, clinicians and patients should be vigilant for the
      potential of hierarchical relationships to foster coercion or silencing of the
      patient's voice.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Epstein, Ronald Mark
AU  - Epstein RM
AD  - Departments of Family Medicine, Psychiatry, Oncology and Nursing and the Center
      for Communication and Disparities Research, University of Rochester Medical
      Center, Rochester, NY, USA. ronald_epstein@urmc.rochester.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120811
PL  - Ireland
TA  - Patient Educ Couns
JT  - Patient education and counseling
JID - 8406280
MH  - Clinical Competence
MH  - Cognition
MH  - *Communication
MH  - *Decision Making
MH  - Ethics, Clinical
MH  - Humans
MH  - *Physician-Patient Relations
EDAT- 2012/08/14 06:00
MHDA- 2013/07/03 06:00
CRDT- 2012/08/14 06:00
PHST- 2012/02/24 00:00 [received]
PHST- 2012/06/24 00:00 [revised]
PHST- 2012/06/29 00:00 [accepted]
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2013/07/03 06:00 [medline]
AID - S0738-3991(12)00294-7 [pii]
AID - 10.1016/j.pec.2012.06.035 [doi]
PST - ppublish
SO  - Patient Educ Couns. 2013 Feb;90(2):200-6. doi: 10.1016/j.pec.2012.06.035. Epub
      2012 Aug 11.


PMID- 22884411
OWN - NLM
STAT- MEDLINE
DCOM- 20130430
LR  - 20191210
IS  - 1873-5134 (Electronic)
IS  - 0738-3991 (Linking)
VI  - 90
IP  - 1
DP  - 2013 Jan
TI  - Complex health care decisions with older patients in general practice:
      patient-centeredness and prioritization in consultations following a geriatric
      assessment.
PG  - 54-60
LID - 10.1016/j.pec.2012.07.015 [doi]
LID - S0738-3991(12)00324-2 [pii]
AB  - OBJECTIVE: To examine to what extent general practitioners in consultations after
      a geriatric assessment set shared health priorities with older patients
      experiencing multimorbidity and to what extent this was facilitated through
      patient-centered behavior. METHODS: Observation of consultations embedded in a
      cluster randomized controlled trial,(1) in which 317 patients from 41 general
      practices received the STEP assessment followed by a care planning consultation
      with their GPs. GPs in the intervention group used a structured procedure for
      setting health (care) priorities in contrast to control GPs. A sample of 43
      consultations (24 intervention; 19 control) were recorded, transcribed and
      analyzed with regard to priority setting and patient-centeredness. RESULTS:
      Patient-centeredness was only moderately apparent in consultations dealing with
      complex care plans for older patients with multimorbidity. The shared
      determination of health priorities seemed unusual for both doctors and patients
      and was rarely practiced, albeit more frequently in intervention consultations.
      CONCLUSION: Setting health care priorities with patients experiencing
      multimorbidity is ethically desirable and medically appropriate. Yet a short
      structured guide for doctors cannot easily achieve this. PRACTICE IMPLICATIONS:
      More research is needed in regard to handling complex health needs of older
      patients. It requires a professional approach and training in patient-centered
      holistic care planning.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Wrede, Jennifer
AU  - Wrede J
AD  - Institute for General Practice, Hannover Medical School, Hannover, Germany.
      JenniWrede@yahoo.de
FAU - Voigt, Isabel
AU  - Voigt I
FAU - Bleidorn, Jutta
AU  - Bleidorn J
FAU - Hummers-Pradier, Eva
AU  - Hummers-Pradier E
FAU - Dierks, Marie-Luise
AU  - Dierks ML
FAU - Junius-Walker, Ulrike
AU  - Junius-Walker U
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20120809
PL  - Ireland
TA  - Patient Educ Couns
JT  - Patient education and counseling
JID - 8406280
MH  - Aged
MH  - Aged, 80 and over
MH  - *Communication
MH  - Comorbidity
MH  - *Decision Making
MH  - Female
MH  - General Practice
MH  - General Practitioners
MH  - *Geriatric Assessment
MH  - Germany
MH  - Humans
MH  - Male
MH  - *Patient Care Planning
MH  - Patient Participation
MH  - *Patient-Centered Care/methods
MH  - *Physician-Patient Relations
MH  - Practice Patterns, Physicians'
MH  - Process Assessment, Health Care
MH  - Referral and Consultation
EDAT- 2012/08/14 06:00
MHDA- 2013/05/01 06:00
CRDT- 2012/08/14 06:00
PHST- 2011/10/20 00:00 [received]
PHST- 2012/05/18 00:00 [revised]
PHST- 2012/07/20 00:00 [accepted]
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2013/05/01 06:00 [medline]
AID - S0738-3991(12)00324-2 [pii]
AID - 10.1016/j.pec.2012.07.015 [doi]
PST - ppublish
SO  - Patient Educ Couns. 2013 Jan;90(1):54-60. doi: 10.1016/j.pec.2012.07.015. Epub
      2012 Aug 9.


PMID- 22884277
OWN - NLM
STAT- MEDLINE
DCOM- 20130506
LR  - 20150408
IS  - 2172-6825 (Electronic)
IS  - 0873-2159 (Linking)
VI  - 18
IP  - 6
DP  - 2012 Nov-Dec
TI  - Reporting of ethical committee approval and patient consent in the Portuguese
      Journal of Pulmonology and in the other Portuguese medical journals with impact
      factor.
PG  - 289-93
LID - 10.1016/j.rppneu.2012.06.003 [doi]
LID - S0873-2159(12)00094-3 [pii]
AB  - INTRODUCTION: Reporting of ethical committee (EC) approval and patient consent in
      publications involving human subjects may be lower than recommended. In this
      paper this ethical issue was analysed in the Portuguese Journal of Pulmonology
      and in the other two Portuguese medical journals with impact factor indexed in
      the ISI Web of Knowledge. METHODS: Reporting of EC approval and patient consent
      was searched in all publications involving human subjects published in the Acta
      Medica Portuguesa, Acta Reumatologica Portuguesa and Portuguese Journal of
      Pulmonology, from the 1(st) July 2010 until the 30(th) June 2011. The search also
      looked for the involvement of vulnerable and potentially identifiable subjects.
      RESULTS: Most of the analysed publications, which included a considerable
      proportion of vulnerable (23%) and of potentially identifiable case reports
      (14%), were case reports (49%). Overall EC approval ranged from 0% to 28%, in
      case reports and prospective studies, respectively, whereas overall patient
      consent ranged from 0% to 26%. There were not statistically significant
      differences in results among the selected journals. CONCLUSIONS: Reporting of EC 
      approval and patient consent in the three leading Portuguese medical journals has
      been lower than in their leading world counterparts. This should be taken into
      account and further audited in future, not only for the protection of the
      research subjects but also to maintain public trust in the process.
CI  - Copyright (c) 2012 Sociedade Portuguesa de Pneumologia. Published by Elsevier
      Espana. All rights reserved.
FAU - Bernardes, M J
AU  - Bernardes MJ
AD  - Servico de Bioetica e Etica Medica, Faculdade de Medicina, Universidade do Porto,
      Porto, Portugal. mjflbernardes@gmail.com
FAU - Nunes, R
AU  - Nunes R
LA  - eng
LA  - por
PT  - Journal Article
DEP - 20120809
PL  - Spain
TA  - Rev Port Pneumol
JT  - Revista portuguesa de pneumologia
JID - 9813736
SB  - IM
MH  - *Ethics Committees, Clinical
MH  - Humans
MH  - *Informed Consent
MH  - Journal Impact Factor
MH  - *Periodicals as Topic
MH  - Portugal
MH  - Publishing/*ethics
MH  - *Pulmonary Medicine
EDAT- 2012/08/14 06:00
MHDA- 2013/05/07 06:00
CRDT- 2012/08/14 06:00
PHST- 2012/04/29 00:00 [received]
PHST- 2012/06/07 00:00 [revised]
PHST- 2012/06/07 00:00 [accepted]
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2013/05/07 06:00 [medline]
AID - S0873-2159(12)00094-3 [pii]
AID - 10.1016/j.rppneu.2012.06.003 [doi]
PST - ppublish
SO  - Rev Port Pneumol. 2012 Nov-Dec;18(6):289-93. doi: 10.1016/j.rppneu.2012.06.003.
      Epub 2012 Aug 9.


PMID- 22883931
OWN - NLM
STAT- MEDLINE
DCOM- 20140326
LR  - 20130704
IS  - 1478-9523 (Electronic)
IS  - 1478-9515 (Linking)
VI  - 11
IP  - 3
DP  - 2013 Jun
TI  - The ethics of space, design and color in an oncology ward.
PG  - 215-21
LID - 10.1017/S1478951512000077 [doi]
AB  - Change affects all areas of healthcare organizations and none more so than each
      aspect of the oncology ward, beginning with the patient's room. It is there that 
      the issues faced by the major players in healing environments - administrator,
      caregiver, family member, and, most importantly, the patient - come sharply into 
      focus. Hospitals are building new facilities or renovating old ones in order to
      adapt to new environmental demands of patient care and security. Driven by
      ethical and professional responsibility, the oncological team headed by Professor
      Hellmut Samonigg of Graz Medical University Graz pursued a vision of designing a 
      model oncology ward unique in Europe. Friedensreich Hundertwasser, the
      world-famous artist, was the creative force behind the design. The oncology ward 
      became a place of healing, permeated with a colorful sense of life and harmonious
      holistic care. The successful outcome was confirmed by the extraordinarily
      positive feedback by patients, families, and healthcare staff.
FAU - Andritsch, Elisabeth
AU  - Andritsch E
AD  - Clinical Division of Oncology, Department of Internal Medicine, Medical
      University Graz, Graz, Austria. elisabeth.andritsch@klinikum-graz.at
FAU - Stoger, Herbert
AU  - Stoger H
FAU - Bauernhofer, Thomas
AU  - Bauernhofer T
FAU - Andritsch, Hans
AU  - Andritsch H
FAU - Kasparek, Anne-Katrin
AU  - Kasparek AK
FAU - Schaberl-Moser, Renate
AU  - Schaberl-Moser R
FAU - Ploner, Ferdinand
AU  - Ploner F
FAU - Samonigg, Hellmut
AU  - Samonigg H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120810
PL  - England
TA  - Palliat Support Care
JT  - Palliative & supportive care
JID - 101232529
SB  - IM
MH  - *Color
MH  - Europe
MH  - Family
MH  - Humans
MH  - *Interior Design and Furnishings
MH  - Oncology Service, Hospital/*ethics
MH  - Organizational Innovation
MH  - *Patients' Rooms
EDAT- 2012/08/14 06:00
MHDA- 2014/03/29 06:00
CRDT- 2012/08/14 06:00
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2014/03/29 06:00 [medline]
AID - S1478951512000077 [pii]
AID - 10.1017/S1478951512000077 [doi]
PST - ppublish
SO  - Palliat Support Care. 2013 Jun;11(3):215-21. doi: 10.1017/S1478951512000077. Epub
      2012 Aug 10.


PMID- 22883752
OWN - NLM
STAT- MEDLINE
DCOM- 20130830
LR  - 20130306
IS  - 1477-1128 (Electronic)
IS  - 1463-4236 (Linking)
VI  - 14
IP  - 2
DP  - 2013 Apr
TI  - Ethical tensions associated with the promotion of public health policy in health 
      visiting: a qualitative investigation of health visitors' views.
PG  - 200-11
LID - 10.1017/S1463423612000400 [doi]
AB  - AIM: To explore whether and how health visitors experience ethical tensions
      between the public health agenda and the need to be responsive to individual
      clients. BACKGROUND: Current health policy in England gives health visitors a key
      role in implementing the government's public health agenda. Health visitors are
      also required by their Professional Code to respond to the health-related
      concerns and preferences of their individual clients. This may generate tensions.
      METHODS: A total of 17 semi-structured individual interviews covering
      participants' experiences of implementing public health interventions and
      perceptions of the ethical tensions involved were conducted. Interviews were
      audio-recorded, transcribed and analysed thematically using a Framework approach.
      FINDINGS: Health visitors raised a number of ethical concerns, which they
      attributed to organisational resource allocation and the introduction of
      protocols and targets relating to public health goals. They did not always regard
      it as appropriate to raise topics that employing organisations had identified as 
      public health priorities with particular clients for whom they were not
      priorities, or who had other more pressing needs. They noted that resources that 
      were allocated towards reaching public health targets were unavailable for
      clients who needed support in other areas. Organisational protocols designed to
      monitor performance put pressure on health visitors to prioritise achieving
      targets and undermined their ability to exercise professional judgement when
      supporting individual clients. This had implications for health visitors' sense
      of professionalism. Health visitors saw trusting relationships as key to
      effective health visiting practice, but the requirement to implement public
      health priorities, combined with a lack of resources in health visiting, eroded
      their ability to form these. Policies need to be evaluated with regard to their
      impact upon a broader range of processes and outcomes than public health goals.
      The erosion of health visitors' professional values and ability to develop
      relationships with clients could have numerous adverse implications.
FAU - Greenway, Julie Catherine
AU  - Greenway JC
AD  - Centre for Ethics in Medicine, University of Bristol, Bristol, UK.
      julie.greenway@blueyonder.co.uk
FAU - Entwistle, Vikki Ann
AU  - Entwistle VA
FAU - terMeulen, Ruud
AU  - terMeulen R
LA  - eng
GR  - Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120810
PL  - England
TA  - Prim Health Care Res Dev
JT  - Primary health care research & development
JID - 100897390
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Community Health Nursing/*ethics/standards
MH  - Cross-Sectional Studies
MH  - England
MH  - Female
MH  - Health Behavior
MH  - *Health Policy
MH  - Humans
MH  - Interviews as Topic
MH  - Needs Assessment
MH  - Professional-Patient Relations/*ethics
MH  - Public Health/*ethics/standards
MH  - Qualitative Research
MH  - Rural Population
MH  - Socioeconomic Factors
MH  - Urban Population
EDAT- 2012/08/14 06:00
MHDA- 2013/08/31 06:00
CRDT- 2012/08/14 06:00
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2013/08/31 06:00 [medline]
AID - S1463423612000400 [pii]
AID - 10.1017/S1463423612000400 [doi]
PST - ppublish
SO  - Prim Health Care Res Dev. 2013 Apr;14(2):200-11. doi: 10.1017/S1463423612000400. 
      Epub 2012 Aug 10.


PMID- 22883654
OWN - NLM
STAT- MEDLINE
DCOM- 20130131
LR  - 20120813
IS  - 1754-9485 (Electronic)
IS  - 1754-9477 (Linking)
VI  - 56
IP  - 4
DP  - 2012 Aug
TI  - The controversy over vertebroplasty: an analysis of the debate and proposals for 
      a way forward.
PG  - 449-51
LID - 10.1111/j.1754-9485.2012.02409.x [doi]
AB  - This paper examines the ongoing and often heated debate about the merits or
      otherwise of percutaneous vertebroplasty as a treatment for painful osteoporotic 
      vertebral fractures. In spite of the proliferation of research on this topic
      there is no agreement over its indications, safety or efficacy. We discuss the
      ethical issues which arise when new medical interventions such as vertebroplasty 
      are introduced and make suggestions of relevance not just to the case of
      vertebroplasty, but to the introduction of innovative procedures generally.
CI  - (c) 2012 The Authors. Journal of Medical Imaging and Radiation Oncology (c) 2012 
      The Royal Australian and New Zealand College of Radiologists.
FAU - Johnson, Jane
AU  - Johnson J
AD  - Department of Philosophy, Australian School of Advanced Medicine, Macquarie
      University, North Ryde, New South Wales, Australia. jane.johnson@mq.edu.au
FAU - Rogers, Wendy
AU  - Rogers W
FAU - Jeffree, Rosalind L
AU  - Jeffree RL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120708
PL  - Australia
TA  - J Med Imaging Radiat Oncol
JT  - Journal of medical imaging and radiation oncology
JID - 101469340
RN  - 0 (Bone Cements)
SB  - IM
MH  - Bone Cements/*adverse effects/*therapeutic use
MH  - *Evidence-Based Medicine
MH  - Humans
MH  - Osteoporotic Fractures/*therapy
MH  - Spinal Fractures/*therapy
MH  - Vertebroplasty/*adverse effects/*trends
EDAT- 2012/08/14 06:00
MHDA- 2013/02/01 06:00
CRDT- 2012/08/14 06:00
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2013/02/01 06:00 [medline]
AID - 10.1111/j.1754-9485.2012.02409.x [doi]
PST - ppublish
SO  - J Med Imaging Radiat Oncol. 2012 Aug;56(4):449-51. doi:
      10.1111/j.1754-9485.2012.02409.x. Epub 2012 Jul 8.


PMID- 22883613
OWN - NLM
STAT- MEDLINE
DCOM- 20130410
LR  - 20211021
IS  - 1752-8062 (Electronic)
IS  - 1752-8054 (Linking)
VI  - 5
IP  - 4
DP  - 2012 Aug
TI  - Incidental diagnosis in healthy clinical trial subjects.
PG  - 348-50
LID - 10.1111/j.1752-8062.2011.00393.x [doi]
AB  - Previously unrecognized medical conditions identified in volunteers for early
      phase clinical studies have significant clinical and ethical implications for the
      participant. It is therefore crucial that the potential for unexpected diagnosis 
      is addressed during the informed consent process. But the frequency of incidental
      diagnosis in healthy volunteers who attend for clinical trial screening remains
      unclear. To assess this we retrospectively analyzed 1,131 independent screening
      visits for 990 volunteers at a single academic center over a 10-year period to
      describe the frequency and nature of new clinical findings. Overall 23 of 990
      volunteers (2.3%) were excluded at screening for a newly diagnosed medical
      abnormality. Some clinically important conditions, such as nephrotic syndrome and
      familial hypercholesterolemia were identified. The frequency of abnormalities was
      associated with increasing age in males (p= 0.02 chi(2) for trend) but not
      females (p= 0.82). These data will assist those planning and conducting phase
      I/II vaccine trials in healthy volunteers, and importantly should strengthen the 
      informed consent of future trial participants.
CI  - (c) 2012 Wiley Periodicals, Inc.
FAU - Duncan, Christopher J A
AU  - Duncan CJ
AD  - Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford,
      Churchill Drive, OX3 7LJ, United Kingdom. chrisduncan@doctors.net.uk
FAU - Rowland, Rosalind
AU  - Rowland R
FAU - Lillie, Patrick J
AU  - Lillie PJ
FAU - Meyer, Joel
AU  - Meyer J
FAU - Sheehy, Susanne H
AU  - Sheehy SH
FAU - O'Hara, Geraldine A
AU  - O'Hara GA
FAU - Hamill, Matthew
AU  - Hamill M
FAU - Donaldson, Hannah
AU  - Donaldson H
FAU - Dinsmore, Laura
AU  - Dinsmore L
FAU - Poulton, Ian D
AU  - Poulton ID
FAU - Gilbert, Sarah C
AU  - Gilbert SC
FAU - McShane, Helen
AU  - McShane H
FAU - Hill, Adrian V S
AU  - Hill AV
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - 090532/WT_/Wellcome Trust/United Kingdom
GR  - 095780/WT_/Wellcome Trust/United Kingdom
GR  - MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120306
PL  - United States
TA  - Clin Transl Sci
JT  - Clinical and translational science
JID - 101474067
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Clinical Trials as Topic
MH  - Female
MH  - *Health
MH  - Humans
MH  - *Incidental Findings
MH  - Male
MH  - Middle Aged
MH  - Young Adult
PMC - PMC3465775
EDAT- 2012/08/14 06:00
MHDA- 2013/04/11 06:00
CRDT- 2012/08/14 06:00
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2013/04/11 06:00 [medline]
AID - 10.1111/j.1752-8062.2011.00393.x [doi]
PST - ppublish
SO  - Clin Transl Sci. 2012 Aug;5(4):348-50. doi: 10.1111/j.1752-8062.2011.00393.x.
      Epub 2012 Mar 6.


PMID- 22883307
OWN - NLM
STAT- MEDLINE
DCOM- 20130401
LR  - 20220331
IS  - 1479-5876 (Electronic)
IS  - 1479-5876 (Linking)
VI  - 10
DP  - 2012 Aug 10
TI  - Hyperinvasive approach to out-of hospital cardiac arrest using mechanical chest
      compression device, prehospital intraarrest cooling, extracorporeal life support 
      and early invasive assessment compared to standard of care. A randomized parallel
      groups comparative study proposal. "Prague OHCA study".
PG  - 163
LID - 10.1186/1479-5876-10-163 [doi]
AB  - BACKGROUND: Out of hospital cardiac arrest (OHCA) has a poor outcome. Recent
      non-randomized studies of ECLS (extracorporeal life support) in OHCA suggested
      further prospective multicenter studies to define population that would benefit
      from ECLS. We aim to perform a prospective randomized study comparing prehospital
      intraarrest hypothermia combined with mechanical chest compression device,
      intrahospital ECLS and early invasive investigation and treatment in all patients
      with OHCA of presumed cardiac origin compared to a standard of care. METHODS:
      This paper describes methodology and design of the proposed trial. Patients with 
      witnessed OHCA without ROSC (return of spontaneous circulation) after a minimum
      of 5 minutes of ACLS (advanced cardiac life support) by emergency medical service
      (EMS) team and after performance of all initial procedures (defibrillation,
      airway management, intravenous access establishment) will be randomized to
      standard vs. hyperinvasive arm. In hyperinvasive arm, mechanical compression
      device together with intranasal evaporative cooling will be instituted and
      patients will be transferred directly to cardiac center under ongoing CPR
      (cardiopulmonary resuscitation). After admission, ECLS inclusion/exclusion
      criteria will be evaluated and if achieved, veno-arterial ECLS will be started.
      Invasive investigation and standard post resuscitation care will follow. Patients
      in standard arm will be managed on scene. When ROSC achieved, they will be
      transferred to cardiac center and further treated as per recent guidelines.
      PRIMARY OUTCOME: 6 months survival with good neurological outcome (Cerebral
      Performance Category 1-2). Secondary outcomes will include 30 day neurological
      and cardiac recovery. DISCUSSION: Authors introduce and offer a protocol of a
      proposed randomized study comparing a combined "hyperinvasive approach" to a
      standard of care in refractory OHCA. The protocol is opened for sharing by other 
      cardiac centers with available ECLS and cathlab teams trained to admit patients
      with refractory cardiac arrest under ongoing CPR. A prove of concept study will
      be started soon. The aim of the authors is to establish a net of centers for a
      multicenter trial initiation in future. ETHICS AND REGISTRATION: The protocol has
      been approved by an Institutional Review Board, will be supported by a research
      grant from Internal Grant Agency of the Ministry of Health, Czech Republic NT
      13225-4/2012 and has been registered under ClinicalTrials.gov identifier:
      NCT01511666.
FAU - Belohlavek, Jan
AU  - Belohlavek J
AD  - 2nd Department of Medicine, 1st Faculty of Medicine, Charles University in Prague
      and General University Hospital in Prague, U Nemocnice 2, Prague 2 128 00, Czech 
      Republic. jan.belohlavek@vfn.cz
FAU - Kucera, Karel
AU  - Kucera K
FAU - Jarkovsky, Jiri
AU  - Jarkovsky J
FAU - Franek, Ondrej
AU  - Franek O
FAU - Pokorna, Milana
AU  - Pokorna M
FAU - Danda, Jiri
AU  - Danda J
FAU - Skripsky, Roman
AU  - Skripsky R
FAU - Kandrnal, Vit
AU  - Kandrnal V
FAU - Balik, Martin
AU  - Balik M
FAU - Kunstyr, Jan
AU  - Kunstyr J
FAU - Horak, Jan
AU  - Horak J
FAU - Smid, Ondrej
AU  - Smid O
FAU - Valasek, Jaroslav
AU  - Valasek J
FAU - Mrazek, Vratislav
AU  - Mrazek V
FAU - Schwarz, Zdenek
AU  - Schwarz Z
FAU - Linhart, Ales
AU  - Linhart A
LA  - eng
SI  - ClinicalTrials.gov/NCT01511666
GR  - NS 9770-4/2008/NS/NINDS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120810
PL  - England
TA  - J Transl Med
JT  - Journal of translational medicine
JID - 101190741
SB  - IM
MH  - Cardiopulmonary Resuscitation/*instrumentation
MH  - Emergency Medical Services/*organization & administration
MH  - Heart Arrest/*therapy
MH  - Humans
MH  - *Hyperthermia, Induced
PMC - PMC3492121
EDAT- 2012/08/14 06:00
MHDA- 2013/04/02 06:00
CRDT- 2012/08/14 06:00
PHST- 2012/07/06 00:00 [received]
PHST- 2012/07/06 00:00 [accepted]
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2013/04/02 06:00 [medline]
AID - 1479-5876-10-163 [pii]
AID - 10.1186/1479-5876-10-163 [doi]
PST - epublish
SO  - J Transl Med. 2012 Aug 10;10:163. doi: 10.1186/1479-5876-10-163.


PMID- 22882871
OWN - NLM
STAT- MEDLINE
DCOM- 20150402
LR  - 20140128
IS  - 1365-2702 (Electronic)
IS  - 0962-1067 (Linking)
VI  - 23
IP  - 3-4
DP  - 2014 Feb
TI  - Abuse and smoking cessation in clinical practice.
PG  - 361-6
LID - 10.1111/j.1365-2702.2012.04219.x [doi]
AB  - AIMS AND OBJECTIVES: This discursive paper explores issues of abuse during
      smoking cessation counselling. BACKGROUND: During a training session for a
      smoking cessation intervention pilot study, nurses expressed concerns about
      issues of abuse that had previously surfaced during cessation counselling in
      their practice. Abused women are more likely to smoke. As guidelines recommend
      integrating cessation interventions into practice, issues of abuse are likely to 
      surface. METHODS: A literature review and synthesis of abuse and smoking
      cessation was undertaken to arrive at recommendations for practice. RESULTS:
      There are a few suggestions about how to manage abuse within cessation
      counselling, but none have been studied: (1) integrate stress-management
      strategies, (2) assess for abuse, (3) provide separate interventions for partners
      to create a safe environment, and (4) develop interventions that consider the
      relationship couples have with tobacco. However, coping strategies alone do not
      address abuse, screening without treatment is not helpful, and partner
      interventions assume both partners are open to quitting/counselling. In contrast,
      as with all clinical practice, abuse and cessation would be considered separate
      but intertwined problems, and following best practice guidelines for abuse would 
      provide the guidance on how to proceed. After care has been taken to address
      abuse, it is the patient's decision whether to continue with cessation
      counselling. CONCLUSION: Guidelines addresses both care planning and the
      ethical/legal issues associated with the disclosure of abuse and provide a
      practical tool for addressing abuse that obviates the need to tailor cessation
      interventions to abuse. RELEVANCE TO CLINICAL PRACTICE: This paper clarifies a
      relationship between smoking and abuse and the subsequent implications for
      smoking cessation interventions and highlights the importance of addressing abuse
      and smoking cessation separately, even though they are interrelated problems. It 
      provides nurses with appropriate initial responses when abuse is disclosed during
      an unexpected encounter such as during a smoking cessation intervention.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Smith, Patricia M
AU  - Smith PM
AD  - Authors:Patricia M Smith, PhD, Associate Professor, Northern Ontario School of
      Medicine, Thunder Bay, ON; Michelle M Spadoni, DNP, RN, Assistant Professor,
      Lakehead University School of Nursing, Thunder Bay, ON; Veronica M Proper, MPH,
      RN, Research Assistant, Northern Ontario School of Medicine, Thunder Bay, ON,
      Canada.
FAU - Spadoni, Michelle M
AU  - Spadoni MM
FAU - Proper, Veronica M
AU  - Proper VM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120809
PL  - England
TA  - J Clin Nurs
JT  - Journal of clinical nursing
JID - 9207302
MH  - Canada
MH  - Counseling
MH  - Humans
MH  - *Smoking Cessation
OTO - NOTNLM
OT  - abuse
OT  - clinical practice guidelines
OT  - domestic violence
OT  - nurse-led smoking cessation
OT  - smoking cessation
EDAT- 2012/08/14 06:00
MHDA- 2015/04/04 06:00
CRDT- 2012/08/14 06:00
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2015/04/04 06:00 [medline]
AID - 10.1111/j.1365-2702.2012.04219.x [doi]
PST - ppublish
SO  - J Clin Nurs. 2014 Feb;23(3-4):361-6. doi: 10.1111/j.1365-2702.2012.04219.x. Epub 
      2012 Aug 9.


PMID- 22882774
OWN - NLM
STAT- MEDLINE
DCOM- 20140619
LR  - 20181202
IS  - 1467-9566 (Electronic)
IS  - 0141-9889 (Linking)
VI  - 35
IP  - 2
DP  - 2013 Feb
TI  - 'If you have a soul, you will volunteer at once': gendered expectations of duty
      to care during pandemics.
PG  - 304-8
LID - 10.1111/j.1467-9566.2012.01495.x [doi]
AB  - Duty to care has been identified as a pressing ethical issue in contemporary
      discussions of pandemic preparedness; however, nuanced discussions of this
      complicated issue are relatively limited. This article presents historical data
      from the experience of the 1918 influenza pandemic in Brantford, Ontario in
      Canada, demonstrating that, in the face of an actual pandemic, the particular
      construction of duty to care as both moral and gendered meant that women were
      placed at a greater personal risk during this time. Given that women still
      dominate the front lines of healthcare work, we argue that it is critical for
      current stakeholders to reflect on how these historical patterns may be
      replicated in contemporary pandemic planning and response.
CI  - (c) 2012 The Authors. Sociology of Health & Illness 2012 Foundation for the
      Sociology of Health & Illness/Blackwell Publishing Ltd.
FAU - Godderis, Rebecca
AU  - Godderis R
AD  - Health Studies, Wilfrid Laurier University, Brantford, Ontario, Canada.
      rgodderis@wlu.ca
FAU - Rossiter, Kate
AU  - Rossiter K
LA  - eng
GR  - 457178/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120807
PL  - England
TA  - Sociol Health Illn
JT  - Sociology of health & illness
JID - 8205036
SB  - IM
MH  - Adult
MH  - Delivery of Health Care/ethics
MH  - Disaster Planning/trends
MH  - Emergency Responders/*psychology/statistics & numerical data
MH  - Female
MH  - Health Personnel
MH  - Humans
MH  - Male
MH  - *Moral Obligations
MH  - Ontario
MH  - Pandemics/*ethics
MH  - Risk Management/*ethics
MH  - Sex Factors
MH  - *Volunteers/psychology/statistics & numerical data
MH  - Women, Working/psychology/statistics & numerical data
MH  - Workforce
EDAT- 2012/08/14 06:00
MHDA- 2014/06/20 06:00
CRDT- 2012/08/14 06:00
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2014/06/20 06:00 [medline]
AID - 10.1111/j.1467-9566.2012.01495.x [doi]
PST - ppublish
SO  - Sociol Health Illn. 2013 Feb;35(2):304-8. doi: 10.1111/j.1467-9566.2012.01495.x. 
      Epub 2012 Aug 7.


PMID- 22882636
OWN - NLM
STAT- MEDLINE
DCOM- 20130308
LR  - 20151119
IS  - 1467-9450 (Electronic)
IS  - 0036-5564 (Linking)
VI  - 53
IP  - 5
DP  - 2012 Oct
TI  - Empathy and values as predictors of care development.
PG  - 413-20
LID - 10.1111/j.1467-9450.2012.00961.x [doi]
AB  - This study investigates values and affective empathy as predictors for care-based
      moral development. Fifty-three students from a university of applied sciences
      were interviewed with Skoe's Ethic of Care Interview at the beginning of their
      studies and two years later. Value priorities were measured by Schwartz et al.'s 
      Portrait Value Questionnaire, empathy variables by Davis' Interpersonal
      Reactivity Index, and feelings of sympathy were rated using a real-life moral
      conflict. The results showed that students in care-oriented fields progressed in 
      care reasoning. Real-life sympathy and the value of self-direction positively
      predicted development in care reasoning, whereas personal distress was a negative
      predictor. The results indicate that care-based moral development is more closely
      connected with affective empathy than personal values. Individuals who feel
      empathy for others, and who prefer independent thinking and action, achieve the
      greatest gains in care development. In conclusion, educators should encourage
      students' empathy and moral reasoning in authentic moral conflicts.
CI  - (c) 2012 The Authors. Scandinavian Journal of Psychology (c) 2012 The
      Scandinavian Psychological Associations.
FAU - Juujarvi, Soile
AU  - Juujarvi S
AD  - Laurea University of Applied Sciences, Espoo, Finland. soile.juujarvi@laurea.fi
FAU - Myyry, Liisa
AU  - Myyry L
FAU - Pesso, Kaija
AU  - Pesso K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120807
PL  - England
TA  - Scand J Psychol
JT  - Scandinavian journal of psychology
JID - 0404510
SB  - IM
MH  - Adult
MH  - Attitude of Health Personnel
MH  - Caregivers/*psychology/statistics & numerical data
MH  - *Empathy
MH  - Female
MH  - Finland
MH  - Follow-Up Studies
MH  - Health Occupations
MH  - Humans
MH  - *Interpersonal Relations
MH  - Longitudinal Studies
MH  - Male
MH  - *Moral Development
MH  - Social Values
MH  - Students/psychology
MH  - Surveys and Questionnaires
EDAT- 2012/08/14 06:00
MHDA- 2013/03/09 06:00
CRDT- 2012/08/14 06:00
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2013/03/09 06:00 [medline]
AID - 10.1111/j.1467-9450.2012.00961.x [doi]
PST - ppublish
SO  - Scand J Psychol. 2012 Oct;53(5):413-20. doi: 10.1111/j.1467-9450.2012.00961.x.
      Epub 2012 Aug 7.


PMID- 22882518
OWN - NLM
STAT- MEDLINE
DCOM- 20130501
LR  - 20120914
IS  - 1526-4637 (Electronic)
IS  - 1526-2375 (Linking)
VI  - 13
IP  - 9
DP  - 2012 Sep
TI  - Maintaining professionalism in today's business environment: ethical challenges
      for the pain medicine specialist.
PG  - 1152-61
LID - 10.1111/j.1526-4637.2012.01465.x [doi]
AB  - OBJECTIVE: There are many external influences in today's market force that impair
      the relationship between the pain medicine specialist and the patient, and
      ultimately prevent optimal quality of care. This article explores the ethical
      challenges facing the pain medicine specialist in today's increasingly "business"
      environment and will offer solutions for maintaining the professionalism of pain 
      medicine. DISCUSSION: Four commonly encountered bioethical principles in the
      practice of pain medicine are reviewed: beneficence, nonmaleficence, justice, and
      autonomy. The following ethical challenges of the pain medicine specialist are
      reviewed: practicing outside ones specialty area, practice characteristics, the
      consultant role, the economic lure of aggressive intervention, not evaluating for
      and treating comorbid psychopathology, reimbursement pressures, workers'
      compensation, and use of unproven methods. CONCLUSIONS: Solutions offered include
      collegial associations, social responsibility, legislative initiatives, pain
      education, interdisciplinary evaluation and treatment, improved relationships
      with third-party payers, reduced racial disparities, and ethics education. Ethics
      is the "roadmap" that enables the pain medicine specialist to navigate the
      increasingly murky waters of practicing pain management today by maintaining the 
      professionalism necessary to combat today's "business" pressures.
CI  - Wiley Periodicals, Inc.
FAU - Lebovits, Allen
AU  - Lebovits A
AD  - Division of Neurology and Integrative Pain Medicine, ProHEALTH Care Associates,
      LLP, Lake Success, NY 11042, USA. alebovits@prohealthcare.com
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120808
PL  - England
TA  - Pain Med
JT  - Pain medicine (Malden, Mass.)
JID - 100894201
SB  - IM
CIN - Pain Med. 2012 Sep;13(9):1149-51. PMID: 22974013
MH  - Commerce
MH  - *Ethics, Medical
MH  - Humans
MH  - Pain Management/economics/*ethics/methods
EDAT- 2012/08/14 06:00
MHDA- 2013/05/02 06:00
CRDT- 2012/08/14 06:00
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2013/05/02 06:00 [medline]
AID - 10.1111/j.1526-4637.2012.01465.x [doi]
PST - ppublish
SO  - Pain Med. 2012 Sep;13(9):1152-61. doi: 10.1111/j.1526-4637.2012.01465.x. Epub
      2012 Aug 8.


PMID- 22882293
OWN - NLM
STAT- MEDLINE
DCOM- 20130820
LR  - 20211021
IS  - 1369-7625 (Electronic)
IS  - 1369-6513 (Linking)
VI  - 16
IP  - 1
DP  - 2013 Mar
TI  - Governance mechanisms in the physician-patient relationship: a literature review 
      and conceptual framework.
PG  - 14-31
LID - 10.1111/j.1369-7625.2012.00807.x [doi]
AB  - BACKGROUND: The physician-patient relationship is a critical component of the
      integrated approach to excellence in health-care delivery. Although commonly
      modelled within the boundaries of the agency theory and regarded as synonymous to
      an agent-principal interaction, there exists only a sparse understanding about
      the most effective ways of governing it. OBJECTIVE: This article undertakes a
      selective review of the growing body of research on the governance of the
      physician-patient relationship to discuss the current state of the knowledge in
      the field and suggest promising avenues for further exploration. FINDINGS: On the
      basis of an extensive analysis of the relevant literature, we identify two
      emerging streams of inquiry on the trust-based (i.e. trust and ethical oversight)
      and distrust-based (i.e. patient information-empowerment and decision-making
      authority) governance mechanisms of the physician-patient relationship and
      discuss the key findings within each stream. DISCUSSION: To conciliate the
      on-going scholarly debate concerning the efficacy of trust- and distrust-based
      mechanisms, we draw the foundations of a conceptual framework which might serve
      as a guide for more integrative research endeavours on the governance of the
      physician-patient relationship.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Tofan, Gabriela
AU  - Tofan G
AD  - School of Public Health, State University of Medicine and Pharmacy Nicolae
      Testemitanu, Chisinau, Republic of Moldova.
FAU - Bodolica, Virginia
AU  - Bodolica V
FAU - Spraggon, Martin
AU  - Spraggon M
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120810
PL  - England
TA  - Health Expect
JT  - Health expectations : an international journal of public participation in health 
      care and health policy
JID - 9815926
SB  - IM
MH  - Humans
MH  - Models, Theoretical
MH  - *Physician-Patient Relations/ethics
MH  - Physicians/organization & administration/standards
MH  - Power, Psychological
MH  - Trust
PMC - PMC5060640
EDAT- 2012/08/14 06:00
MHDA- 2013/08/21 06:00
CRDT- 2012/08/14 06:00
PHST- 2012/07/04 00:00 [accepted]
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2013/08/21 06:00 [medline]
AID - 10.1111/j.1369-7625.2012.00807.x [doi]
PST - ppublish
SO  - Health Expect. 2013 Mar;16(1):14-31. doi: 10.1111/j.1369-7625.2012.00807.x. Epub 
      2012 Aug 10.


PMID- 22881863
OWN - NLM
STAT- MEDLINE
DCOM- 20121102
LR  - 20181201
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 12
IP  - 9
DP  - 2012
TI  - Response to open peer commentaries on "can medical repatriation be ethical?
      Establishing best practices".
PG  - W1-3
LID - 10.1080/15265161.2012.701563 [doi]
FAU - Kuczewski, Mark
AU  - Kuczewski M
AD  - Loyola University Chicago Stritch School of Medicine, Maywood, IL 60153, USA.
      mkuczew@lumc.edu
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2012;12(9):1-5. PMID: 22881842
MH  - *Cost of Illness
MH  - Delivery of Health Care/*economics/*ethics
MH  - *Economics, Hospital
MH  - Hospitals/*ethics
MH  - Humans
MH  - *Medically Uninsured
MH  - *Transients and Migrants
EDAT- 2012/08/14 06:00
MHDA- 2012/11/03 06:00
CRDT- 2012/08/14 06:00
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2012/11/03 06:00 [medline]
AID - 10.1080/15265161.2012.701563 [doi]
PST - ppublish
SO  - Am J Bioeth. 2012;12(9):W1-3. doi: 10.1080/15265161.2012.701563.


PMID- 22881851
OWN - NLM
STAT- MEDLINE
DCOM- 20121102
LR  - 20181201
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 12
IP  - 9
DP  - 2012
TI  - Uncanny animals: thinking differently about ethics and the animal-human
      relationship.
PG  - 30-2
LID - 10.1080/15265161.2012.699143 [doi]
FAU - Irvine, Rob
AU  - Irvine R
AD  - University of Sydney, Centre for Values, Ethics and the Law in Medicine,
      Australia. rirvine@med.usyd.edu.au
FAU - Degeling, Chris
AU  - Degeling C
FAU - Kerridge, Ian
AU  - Kerridge I
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2012;12(9):17-25. PMID: 22881848
MH  - Animal Experimentation/*ethics
MH  - Animals
MH  - *Chimera
MH  - *Human Body
MH  - Humans
MH  - *Moral Obligations
EDAT- 2012/08/14 06:00
MHDA- 2012/11/03 06:00
CRDT- 2012/08/14 06:00
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2012/11/03 06:00 [medline]
AID - 10.1080/15265161.2012.699143 [doi]
PST - ppublish
SO  - Am J Bioeth. 2012;12(9):30-2. doi: 10.1080/15265161.2012.699143.


PMID- 22881848
OWN - NLM
STAT- MEDLINE
DCOM- 20121102
LR  - 20120813
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 12
IP  - 9
DP  - 2012
TI  - Reframing the ethical issues in part-human animal research: the unbearable
      ontology of inexorable moral confusion.
PG  - 17-25
LID - 10.1080/15265161.2012.699139 [doi]
AB  - Research that involves the creation of animals with human-derived parts opens the
      door to potentially valuable scientific and therapeutic advances, yet invokes
      unsettling moral questions. Critics and champions alike stand to gain from clear 
      identification and careful consideration of the strongest ethical objections to
      this research. A prevailing objection argues that crossing the human/nonhuman
      species boundary introduces inexorable moral confusion (IMC) that warrants a
      restriction to this research on precautionary grounds. Though this objection may 
      capture the intuitions of many who find this research unsettling, it relies on
      mistaken views of both biology and moral standing, ultimately distorting the
      morally relevant facts. We critically examine IMC, identify mistaken essentialist
      assumptions, and reframe ethical concerns. The upshot is a stronger line of
      objection that encourages a more inclusive and productive ethical discourse.
FAU - Haber, Matthew H
AU  - Haber MH
AD  - University of Utah, Salt Lake City, 84112, USA. matt.haber@utah.edu
FAU - Benham, Bryan
AU  - Benham B
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CIN - Am J Bioeth. 2012;12(9):26-8. PMID: 22881849
CIN - Am J Bioeth. 2012;12(9):28-30. PMID: 22881850
CIN - Am J Bioeth. 2012;12(9):30-2. PMID: 22881851
CIN - Am J Bioeth. 2012;12(9):32-4. PMID: 22881852
CIN - Am J Bioeth. 2012;12(9):34-5. PMID: 22881853
MH  - Animal Experimentation/*ethics
MH  - Animals
MH  - *Chimera
MH  - Ethical Analysis
MH  - Ethics, Research
MH  - *Human Body
MH  - Humans
MH  - *Moral Obligations
MH  - Terminology as Topic
EDAT- 2012/08/14 06:00
MHDA- 2012/11/03 06:00
CRDT- 2012/08/14 06:00
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2012/11/03 06:00 [medline]
AID - 10.1080/15265161.2012.699139 [doi]
PST - ppublish
SO  - Am J Bioeth. 2012;12(9):17-25. doi: 10.1080/15265161.2012.699139.


PMID- 22881842
OWN - NLM
STAT- MEDLINE
DCOM- 20121102
LR  - 20120813
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 12
IP  - 9
DP  - 2012
TI  - Can medical repatriation be ethical? Establishing best practices.
PG  - 1-5
LID - 10.1080/15265161.2012.692433 [doi]
AB  - Hospitals in the United States have been engaging in the practice of returning
      immigrant patients, usually undocumented immigrant patients, to their country of 
      origin when the patient has long-term medical needs for which no reimbursement is
      available. I argue that for such an action to be ethical, it must be done in
      accordance with the mission and values of hospitals. I describe three standards
      that an individual instance of repatriation must meet to be ethical: (1) patient 
      best interests, (2) medical due diligence, and (3) informed consent. I argue that
      these should form the basis for best practices in regard to medical repatriation 
      for all hospitals in the United States.
FAU - Kuczewski, Mark
AU  - Kuczewski M
AD  - Loyola University Chicago Stritch School of Medicine, Maywood, IL 60153, USA.
      mkuczew@lumc.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CIN - Am J Bioeth. 2012;12(9):6-7. PMID: 22881843
CIN - Am J Bioeth. 2012;12(9):8-9. PMID: 22881844
CIN - Am J Bioeth. 2012;12(9):9-11. PMID: 22881845
CIN - Am J Bioeth. 2012;12(9):11-3. PMID: 22881846
CIN - Am J Bioeth. 2012;12(9):14-6. PMID: 22881847
CIN - Am J Bioeth. 2012;12(9):W1-3. PMID: 22881863
MH  - *Cost of Illness
MH  - Delivery of Health Care/*economics/*ethics
MH  - *Economics, Hospital
MH  - Ethics, Institutional
MH  - Ethics, Medical
MH  - Health Care Costs
MH  - Hospitals/*ethics
MH  - Humans
MH  - Informed Consent/ethics
MH  - *Medically Uninsured
MH  - Patient Advocacy
MH  - Practice Guidelines as Topic
MH  - Public Policy
MH  - *Transients and Migrants
MH  - United States
EDAT- 2012/08/14 06:00
MHDA- 2012/11/03 06:00
CRDT- 2012/08/14 06:00
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2012/11/03 06:00 [medline]
AID - 10.1080/15265161.2012.692433 [doi]
PST - ppublish
SO  - Am J Bioeth. 2012;12(9):1-5. doi: 10.1080/15265161.2012.692433.


PMID- 22881717
OWN - NLM
STAT- MEDLINE
DCOM- 20131205
LR  - 20120928
IS  - 1521-0669 (Electronic)
IS  - 0888-0018 (Linking)
VI  - 29
IP  - 7
DP  - 2012 Oct
TI  - A rare case of congenital choroid plexus carcinoma.
PG  - 643-6
AB  - We report a 1-year-old child with the prenatal (week 29 + 5) diagnosis of a brain
      tumor. The parents were informed about all aspects of prognosis and options
      concerning termination of pregnancy. The parents opted for an aggressive
      therapeutic approach after extensive and informative case conferences and
      counseling. The histopathological diagnosis after partial tumor resection was
      choroid plexus carcinoma, two weeks thereafter tumor size was progressive. The
      parents opted for palliative treatment at this stage. The patient died at the age
      of one year. Ethical aspects have to be actively considered and addressed when
      caring for children with choroid plexus carcinoma.
FAU - Wilhelm, Miriam
AU  - Wilhelm M
AD  - Department of Women and Child Health, Hospital for Children and Adolescents,
      University of Leipzig, Leipzig, Germany.
FAU - Hirsch, Wolfgang
AU  - Hirsch W
FAU - Merkenschlager, Andreas
AU  - Merkenschlager A
FAU - Stepan, Holger
AU  - Stepan H
FAU - Geyer, Christian
AU  - Geyer C
FAU - Kiess, Wieland
AU  - Kiess W
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20120810
PL  - England
TA  - Pediatr Hematol Oncol
JT  - Pediatric hematology and oncology
JID - 8700164
RN  - Choroid Plexus Carcinoma
SB  - IM
MH  - Brain Neoplasms/*congenital/diagnosis/therapy
MH  - Carcinoma/*congenital/diagnosis/therapy
MH  - Choroid Plexus Neoplasms/*congenital/diagnosis/therapy
MH  - Disease Progression
MH  - Fatal Outcome
MH  - Humans
MH  - Infant
MH  - Prognosis
EDAT- 2012/08/14 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/08/14 06:00
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.3109/08880018.2012.710298 [doi]
PST - ppublish
SO  - Pediatr Hematol Oncol. 2012 Oct;29(7):643-6. doi: 10.3109/08880018.2012.710298.
      Epub 2012 Aug 10.


PMID- 22880544
OWN - NLM
STAT- MEDLINE
DCOM- 20120828
LR  - 20120813
IS  - 0279-1072 (Print)
IS  - 0279-1072 (Linking)
VI  - 44
IP  - 2
DP  - 2012 Apr-Jun
TI  - Growing our own: building a native research team.
PG  - 160-5
AB  - In 2006, American Indian/Alaska Natives (AI/AN) made up less than 1% of the
      science, engineering and health doctorates in the U.S. Early introduction of
      AI/AN students to research and continued opportunities are necessary to develop
      successful AI/AN researchers who can better serve their communities. This team
      was developed to form a cohort of American Indian students, staff and faculty
      interested in research and becoming researchers. Since implementation, the
      program grew from one student to over 20 AI students ranging from freshmen just
      entering college to doctoral students working to complete their dissertations.
      This article highlights the team growth, increasing structure, student needs and 
      the faculty and staff involved. It further addresses the support and educational 
      aspects of growing an ongoing, multidisciplinary research team committed to
      ethical research in Native communities. The team addresses substance use
      prevalence, the relationship of substance abuse to other mental health diagnoses,
      and treatment issues. The team includes weekly team meetings, a Blackboard site
      on the Internet that is populated with resources and focused on sharing materials
      and information, a weekly journal club discussion of research articles, and
      collaborative discussions on each project and the barriers and challenges that
      need to be addressed to move forward.
FAU - Gray, Jacqueline S
AU  - Gray JS
AD  - The Center for Rural Health, University of North Dakota, 501 N. Columbia Rd.,
      Stop 9037, Grand Forks, ND 58202-9037, USA. Jacqueline.gray@med.und.edu
FAU - Carter, Paula M
AU  - Carter PM
LA  - eng
GR  - U261HS300127/HS/AHRQ HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Psychoactive Drugs
JT  - Journal of psychoactive drugs
JID - 8113536
SB  - IM
MH  - Biomedical Research/education/*organization & administration
MH  - *Career Choice
MH  - Community-Based Participatory Research/*organization & administration
MH  - Cooperative Behavior
MH  - Cultural Characteristics
MH  - Humans
MH  - *Indians, North American/education/psychology
MH  - Interinstitutional Relations
MH  - Interpersonal Relations
MH  - Leadership
MH  - Mentors
MH  - *Minority Groups/education/psychology
MH  - North Dakota
MH  - Organizational Objectives
EDAT- 2012/08/14 06:00
MHDA- 2012/08/29 06:00
CRDT- 2012/08/14 06:00
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2012/08/29 06:00 [medline]
AID - 10.1080/02791072.2012.684632 [doi]
PST - ppublish
SO  - J Psychoactive Drugs. 2012 Apr-Jun;44(2):160-5. doi:
      10.1080/02791072.2012.684632.


PMID- 22880495
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20120813
IS  - 0297-2964 (Print)
IS  - 0297-2964 (Linking)
IP  - 109
DP  - 2012 Jun
TI  - [Looking over the progress of care. Historical and ethical aspects of the
      relations between health professionals and patients].
PG  - 16-32
AB  - If the idea of care materializes by a friendly behaviour, word or movement, the
      characters who implemented it have seemed, over the history, motivated by varied 
      ideals. Certainly, their name, status and role have not always been precisely
      described; but their intervention happens to be bound to moral and scientific
      requirements enriched by collective representations. So after the nobility
      welcome of the wandering, impoverished and sick stranger, related by Homeric and 
      biblical narratives, the more or less protected professional organization has
      appeared on behalf of the Greek city, then the Roman one. The image of the
      suffering Christ has then imposed itself where the distress of the patient could 
      be read; it constituted the engine of the charity due to the latter, whose
      demonstrations proliferated in the Middle Ages. However, because of the necessary
      disease prevention in front of epidemics which stressed the increasing
      opportunities of war and travel, a more and more complex institutional
      organization has established itself little by little bound to technical and
      political considerations. More precisely, in the last two centuries, the social
      unrest bearing aspiration to public health and people's safety has underlied
      Republican ideals of freedom, solidarity and individual expression. This is what 
      the Nursing staff duty - officially recognized as "healthcare professionals" -
      responds to today to ensure favorable conditions to the dawn of feelings of
      comfort, self-fulfillment and respect. As much by caring and listening they
      ensure as by technical acts they operate, they in fact, participate in the
      implementation of a distribution of common wealth. Health and welcome of the most
      deprived therefore constitute, thanks to their thoughtful intervention, the
      stammerings of a policy of active citizenship.
FAU - Geadah, Roland-Ramzi
AU  - Geadah RR
AD  - C.I.C.E.R.F., Champs-sur-Marne. cicerf@wanadoo.fr
LA  - fre
PT  - English Abstract
PT  - Historical Article
PT  - Journal Article
TT  - Regards sur l'evolution des soins. Aspects historique et ethique des relations
      entre professionnels de sante et patients.
PL  - France
TA  - Rech Soins Infirm
JT  - Recherche en soins infirmiers
JID - 9715370
MH  - History of Nursing
MH  - History, 15th Century
MH  - History, 16th Century
MH  - History, 17th Century
MH  - History, 18th Century
MH  - History, 19th Century
MH  - History, 20th Century
MH  - History, 21st Century
MH  - History, Ancient
MH  - History, Medieval
MH  - Humans
MH  - *Nurse-Patient Relations
MH  - Patient Rights/history
MH  - *Physician-Patient Relations
EDAT- 2012/08/14 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/08/14 06:00
PHST- 2012/08/14 06:00 [entrez]
PHST- 2012/08/14 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
PST - ppublish
SO  - Rech Soins Infirm. 2012 Jun;(109):16-32.


PMID- 22879752
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1178-2218 (Electronic)
IS  - 1178-2218 (Linking)
VI  - 6
DP  - 2012
TI  - Researching Prescription Drug Misuse among First Nations in Canada: Starting from
      a Health Promotion Framework.
PG  - 23-31
LID - 10.4137/SART.S9247 [doi]
AB  - The intentional misuse of psychotropic drugs is recognized as a significant
      public health concern in Canada, although there is a lack of empirical research
      detailing this. Even less research has been documented on the misuse of
      prescription drugs among First Nations in Canada. In the past, Western biomedical
      and individual-based approaches to researching Indigenous health have been
      applied, whereas First Nations' understandings of health are founded on a
      holistic view of wellbeing. Recognition of this disjuncture, alongside the
      protective influence of First Nations traditional culture, is foundational to
      establishing an empirical understanding of and comprehensive response to
      prescription drug misuse. We propose health promotion as a framework from which
      to begin to explore this. Our work with a health promotion framework has conveyed
      its potential to support the consideration of Western and Indigenous worldviews
      together in an 'ethical space', with illustrations provided. Health promotion
      also allots for the consideration of Canada's colonial history of knowledge
      production in public health and supports First Nations' self-determination. Based
      on this, we recommend three immediate ways in which a health promotion framework 
      can advance research on prescription drug misuse among First Nations in Canada.
FAU - Dell, Colleen Anne
AU  - Dell CA
AD  - University of Saskatchewan, Department of Sociology and School of Public Health, 
      Saskatoon, Saskatchewan, Canada.
FAU - Roberts, Gary
AU  - Roberts G
FAU - Kilty, Jennifer
AU  - Kilty J
FAU - Taylor, Kelli
AU  - Taylor K
FAU - Daschuk, Mitch
AU  - Daschuk M
FAU - Hopkins, Carol
AU  - Hopkins C
FAU - Dell, Debra
AU  - Dell D
LA  - eng
PT  - Journal Article
DEP - 20120328
PL  - United States
TA  - Subst Abuse
JT  - Substance abuse : research and treatment
JID - 101514834
PMC - PMC3411531
OTO - NOTNLM
OT  - First Nations
OT  - Indigenous health
OT  - health promotion framework
OT  - intentional prescription drug misuse
EDAT- 2012/08/11 06:00
MHDA- 2012/08/11 06:01
CRDT- 2012/08/11 06:00
PHST- 2012/08/11 06:00 [entrez]
PHST- 2012/08/11 06:00 [pubmed]
PHST- 2012/08/11 06:01 [medline]
AID - 10.4137/SART.S9247 [doi]
AID - sart-6-2012-023 [pii]
PST - ppublish
SO  - Subst Abuse. 2012;6:23-31. doi: 10.4137/SART.S9247. Epub 2012 Mar 28.


PMID- 22879074
OWN - NLM
STAT- MEDLINE
DCOM- 20130118
LR  - 20180802
IS  - 1424-3997 (Electronic)
IS  - 0036-7672 (Linking)
VI  - 142
DP  - 2012
TI  - Ethical research on the implementation of DRGs in Switzerland--a challenging
      project.
PG  - w13610
LID - 10.4414/smw.2012.13610 [doi]
LID - Swiss Med Wkly. 2012;142:w13610 [pii]
AB  - Diagnosis Related Groups (DRGs) are currently being introduced on a national
      scale as a prospective reimbursement scheme in Swiss in-patient hospital care,
      replacing any remaining retrospective day-rate arrangements. DRGs are expected to
      promote transparency and efficiency while helping to contain health care costs.
      The governmental decision to introduce DRGs has caused considerable controversy
      among different stakeholders, due to diverging appraisals of what will happen
      when DRGs are introduced as an economic management tool in Switzerland. The
      controversial discourse on DRGs is particularly interesting from an ethical point
      of view, since all arguments inevitably contain ethical considerations. In this
      paper we summarise the results of our exploratory ethical studies that have led
      to a larger research project funded by the Swiss National Science Foundation:
      "Impact of Diagnosis-Related Groups (DRGs) on patient care and professional
      practice" (IDoC). In section 1: 'Developing an understanding of the ethical
      issues at stake' we briefly explain how DRGs work, what the intended effects are,
      what the public is concerned about and what the scientific research tells us so
      far. In section 2: 'Developing an ethical framework for research on DRGs in
      Switzerland' we summarise the ethical issues and explain the ethical framework we
      will use in order to perform research on the complex issue of DRGs in
      Switzerland. Only once a profound understanding of the challenges exists can
      research on the ethical implications of DRGs be successful.
FAU - Wild, Verina
AU  - Wild V
AD  - Institute of Biomedical Ethics, University of Zurich, Switzerland.
      wild@ethik.uzh.ch
FAU - Pfister, Eliane
AU  - Pfister E
FAU - Biller-Andorno, Nikola
AU  - Biller-Andorno N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120809
PL  - Switzerland
TA  - Swiss Med Wkly
JT  - Swiss medical weekly
JID - 100970884
SB  - IM
MH  - Cost Control
MH  - Diagnosis-Related Groups/economics/*ethics/standards
MH  - *Health Care Costs
MH  - Humans
MH  - Quality of Health Care/economics/*ethics
MH  - Switzerland
EDAT- 2012/08/11 06:00
MHDA- 2013/01/19 06:00
CRDT- 2012/08/11 06:00
PHST- 2012/08/11 06:00 [entrez]
PHST- 2012/08/11 06:00 [pubmed]
PHST- 2013/01/19 06:00 [medline]
AID - 10.4414/smw.2012.13610 [doi]
AID - smw-13610 [pii]
PST - epublish
SO  - Swiss Med Wkly. 2012 Aug 9;142:w13610. doi: 10.4414/smw.2012.13610. eCollection
      2012.


PMID- 22878869
OWN - NLM
STAT- MEDLINE
DCOM- 20130531
LR  - 20211021
IS  - 1438-8359 (Electronic)
IS  - 0913-8668 (Linking)
VI  - 26
IP  - 6
DP  - 2012 Dec
TI  - Penehyclidine enhances the efficacy of tropisetron in prevention of PONV
      following gynecological laparoscopic surgery.
PG  - 864-9
LID - 10.1007/s00540-012-1443-1 [doi]
AB  - PURPOSE: Postoperative nausea and vomiting (PONV) are common complications after 
      gynecological laparoscopic surgery. Because monotherapy with antiemetics is
      insufficient, combinations of various antiemetics are often recommended by
      experts. In this study, our purpose was to find out whether penehyclidine could
      enhance the efficacy of tropisetron in preventing PONV. METHODS: With hospital
      ethics committee approval, we investigated 120 women undergoing gynecological
      laparoscopic surgery receiving prophylactic tropisetron (0.1 mg/kg; maximal dose,
      5 mg) (group T) or tropisetron (0.1 mg/kg; maximal dose, 5 mg) plus penehyclidine
      (0.01 mg/kg; maximal dose, 1 mg) (group TP), or penehyclidine (0.01 mg/kg;
      maximal dose, 1 mg) (group P). The incidence of vomiting, the intensity of nausea
      (assessed by a visual analogue scale [VAS]), antiemetic rescues, and adverse
      effects were recorded at 2, 6, 12, and 24 h after surgery in the gynecological
      ward by a visiting nurse anesthetist who was unaware of the treatments. Collected
      data were analyzed using analysis of variance (ANOVA) and the chi(2) test.
      Continuous variables were expressed as means +/- SD, and non-continuous variables
      were expressed as n (%). RESULTS: The overall incidence of vomiting was 28.3 %
      (34/120) in our study. The incidence of vomiting was significantly lower in group
      TP (4 cases, 10 %) than that in group T (12 cases, 30 %) and group P (18 cases,
      45 %). The incidence of vomiting in group TP was also significantly lower than
      that in group T at 0-2 h and 2-6 h postoperatively and it was also significantly 
      lower than that in group P at 0-2 h, 2-6 h, 6-12 h, and 12-24 h postoperatively. 
      The incidence of vomiting was significantly lower in group T than that in group P
      at 12-24 h postoperatively. The VAS of nausea was significantly lower in group TP
      than that in group T and group P at 2 and 6 h after surgery. It also showed a
      significant higher score in group P than that at group T and group TP at 12 and
      24 h. Within group P, the VAS of nausea was significantly lower at 2 h
      postoperatively than that at 24 h. CONCLUSIONS: Penehyclidine showed less
      efficacy in preventing PONV than tropisetron; however, compared with tropisetron 
      or penehyclidine monotherapy, prophylactic medication with tropisetron plus
      penehyclidine significantly reduced the incidence of vomiting and decreased the
      intensity of nausea in women undergoing gynecological laparoscopic surgery.
FAU - Zhang, Zhiming
AU  - Zhang Z
AD  - Department of Anesthesiology, The First People's Hospital of Chenzhou, Institute 
      of Translation Medicine, Chenzhou, 423000, Hunan, People's Republic of China.
FAU - Zhuang, Yuehong
AU  - Zhuang Y
FAU - Ouyang, Fang
AU  - Ouyang F
FAU - Zhang, Ansheng
AU  - Zhang A
FAU - Zeng, Bin
AU  - Zeng B
FAU - Gu, Miaoning
AU  - Gu M
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20120810
PL  - Japan
TA  - J Anesth
JT  - Journal of anesthesia
JID - 8905667
RN  - 0 (Antiemetics)
RN  - 0 (Cholinergic Antagonists)
RN  - 0 (Indoles)
RN  - 0 (Quinuclidines)
RN  - 353CX8CSHD (penehyclidine)
RN  - 6I819NIK1W (Tropisetron)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anesthesia, General
MH  - Antiemetics/adverse effects/*therapeutic use
MH  - Cholinergic Antagonists/adverse effects/*therapeutic use
MH  - Drug Therapy, Combination
MH  - Female
MH  - Gynecologic Surgical Procedures/*adverse effects
MH  - Humans
MH  - Indoles/adverse effects/*therapeutic use
MH  - Laparoscopy/*adverse effects
MH  - Postoperative Nausea and Vomiting/epidemiology/*prevention & control
MH  - Quinuclidines/adverse effects/*therapeutic use
MH  - Tropisetron
MH  - Young Adult
EDAT- 2012/08/11 06:00
MHDA- 2013/06/01 06:00
CRDT- 2012/08/11 06:00
PHST- 2012/02/16 00:00 [received]
PHST- 2012/06/19 00:00 [accepted]
PHST- 2012/08/11 06:00 [entrez]
PHST- 2012/08/11 06:00 [pubmed]
PHST- 2013/06/01 06:00 [medline]
AID - 10.1007/s00540-012-1443-1 [doi]
PST - ppublish
SO  - J Anesth. 2012 Dec;26(6):864-9. doi: 10.1007/s00540-012-1443-1. Epub 2012 Aug 10.


PMID- 22878491
OWN - NLM
STAT- MEDLINE
DCOM- 20130527
LR  - 20180302
IS  - 1559-0488 (Electronic)
IS  - 1559-047X (Linking)
VI  - 33
IP  - 6
DP  - 2012 Nov-Dec
TI  - Ketamine-propofol vs ketamine-dexmedetomidine combinations in pediatric patients 
      undergoing burn dressing changes.
PG  - 718-22
LID - 10.1097/BCR.0b013e3182504316 [doi]
AB  - The aim of this study was to compare ketamine-propofol (KP) and
      ketamine-dexmedetomidine (KD) combinations for deep sedation and analgesia during
      pediatric burn wound dressing changes. After obtaining approval from the
      University Ethics Committee, burn wound care or wound dressing changes were
      performed on 60 American Society of Anesthesiologists physical status I and II
      inpatients aged between 8 and 60 months with second-degree burns ranging from 5
      to 25% TBSA. After recording the demographic data, the heart rate, systolic
      arterial pressure, diastolic arterial pressure, peripheral oxygen saturation,
      respiratory rate, and Ramsey sedation scores were recorded for all patients
      before and during the procedure. Group KP (n = 30) received 1 mg kg(-)(1)
      ketamine + 1 mg kg(-)(1) propofol and group KD (n = 30) received 1 mg kg(-)(1)
      ketamine + 0.5 mug kg(-)(1) dexmedetomidine for induction. Additional propofol (1
      mg kg(-)(1)) for group KP and additional dexmedetomidine (0.5 mug kg(-)(1)) for
      group KD were administered when required. No statistically significant
      differences in sedation scores and peripheral oxygen saturation and diastolic
      arterial pressure (P > .05) were found between the two groups. However, systolic 
      blood pressure values in group KD showed a significant increase after induction
      (P < .05). The recovery time was longer in group KD than in group KP (P < .05).
      The respiratory rate was higher in group KD than in group KP beginning from the
      fifth minute of the procedure. A significant amount of respiratory depression and
      hypoxia was observed in group KP but not in KD (P < .05). Both the KP and KD
      combinations were effective for sedation and analgesia during dressing changes in
      the pediatric burn patients. The KD combination can be considered as an excellent
      alternative for pediatric wound dressing changes which does not result in
      respiratory depression.
FAU - Canpolat, Dilek Gunay
AU  - Canpolat DG
AD  - Department of Anesthesiology, Kayseri Education and Research Hospital, Kayseri,
      Turkey.
FAU - Esmaoglu, Aliye
AU  - Esmaoglu A
FAU - Tosun, Zeynep
AU  - Tosun Z
FAU - Akn, Aynur
AU  - Akn A
FAU - Boyaci, Adem
AU  - Boyaci A
FAU - Coruh, Atilla
AU  - Coruh A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - J Burn Care Res
JT  - Journal of burn care & research : official publication of the American Burn
      Association
JID - 101262774
RN  - 0 (Anesthetics, Dissociative)
RN  - 0 (Hypnotics and Sedatives)
RN  - 67VB76HONO (Dexmedetomidine)
RN  - 690G0D6V8H (Ketamine)
RN  - YI7VU623SF (Propofol)
SB  - IM
MH  - Analysis of Variance
MH  - Anesthetics, Dissociative/*administration & dosage
MH  - *Bandages
MH  - Burns/*therapy
MH  - Chi-Square Distribution
MH  - Child, Preschool
MH  - Dexmedetomidine/*administration & dosage
MH  - Drug Therapy, Combination
MH  - Humans
MH  - Hypnotics and Sedatives/*administration & dosage
MH  - Infant
MH  - Ketamine/*administration & dosage
MH  - Propofol/*administration & dosage
MH  - Prospective Studies
MH  - Treatment Outcome
EDAT- 2012/08/11 06:00
MHDA- 2013/05/29 06:00
CRDT- 2012/08/11 06:00
PHST- 2012/08/11 06:00 [entrez]
PHST- 2012/08/11 06:00 [pubmed]
PHST- 2013/05/29 06:00 [medline]
AID - 10.1097/BCR.0b013e3182504316 [doi]
PST - ppublish
SO  - J Burn Care Res. 2012 Nov-Dec;33(6):718-22. doi: 10.1097/BCR.0b013e3182504316.


PMID- 22878148
OWN - NLM
STAT- MEDLINE
DCOM- 20121119
LR  - 20151119
IS  - 1095-8673 (Electronic)
IS  - 0022-4804 (Linking)
VI  - 177
IP  - 2
DP  - 2012 Oct
TI  - Get on your boots: preparing fourth-year medical students for a career in
      surgery, using a focused curriculum to teach the competency of professionalism.
PG  - 217-23
LID - 10.1016/j.jss.2012.06.019 [doi]
AB  - INTRODUCTION: Few educational programs exist for medical students that address
      professionalism in surgery, even though this core competency is required for
      graduate medical education and maintenance of board certification. Lapses in
      professional behavior occur commonly in surgical disciplines, with a negative
      effect on the operative team and patient care. Therefore, education regarding
      professionalism should begin early in the surgeon's formative process, to improve
      behavior. The goal of this project was to enhance the attitudes and knowledge of 
      medical students regarding professionalism, to help them understand the role of
      professionalism in a surgical practice. METHODS: We implemented a 4-h seminar,
      spread out as 1-h sessions over the course of their month-long rotation, for
      4th-year medical students serving as acting interns (AIs) in General Surgery, a
      surgical subspecialty, Obstetrics/Gynecology, or Anesthesia. Teaching methods
      included lecture, small group discussion, case studies, and journal club. Topics 
      included Cognitive/Ethical Basis of Professionalism, Behavioral/Social Components
      of Professionalism, Managing Yourself, and Leading While You Work. We assessed
      attitudes about professionalism with a pre-course survey and tracked effect on
      learning and behavior with a post-course questionnaire. We asked AIs to rate the 
      egregiousness of 30 scenarios involving potential lapses in professionalism.
      RESULTS: A total of 104 AIs (mean age, 26.5 y; male to female ratio, 1.6:1)
      participated in our course on professionalism in surgery. Up to 17.8% of the AIs 
      had an alternate career before coming to medical school. Distribution of intended
      careers was: General Surgery, 27.4%; surgical subspecialties, 46.6%;
      Obstetrics/Gynecology, 13.7%; and Anesthesia, 12.3%. Acting interns ranked
      professionalism as the third most important of the six core competencies, after
      clinical skills and medical knowledge, but only slightly ahead of communication. 
      Most AIs believed that professionalism could be taught and learned, and that the 
      largest obstacle was not enough time in the curriculum. The most effective
      reported teaching methods were mentoring and modeling; lecture and journal club
      were the effective. Regarding attitudes toward professionalism, the most
      egregious examples of misconduct were substance abuse, illegal billing, boundary 
      issues, sexual harassment, and lying about patient data, whereas the least
      egregious examples were receiving textbooks or honoraria from drug companies,
      advertising, self-prescribing for family members, and exceeding work-hour
      restrictions. The most important attributes of the professional were integrity
      and honesty, whereas the least valued were autonomy and altruism. The AIs
      reported that the course significantly improved their ability to define
      professionalism, identify attributes of the professional, understand the
      importance of professionalism, and integrate these concepts into practice (all P 
      < 0.01). CONCLUSIONS: Although medical students interested in surgery may already
      have well-formed attitudes and sophisticated knowledge about professionalism,
      this core competency can still be taught to and learned by trainees pursuing a
      surgical career.
CI  - Copyright (c) 2012. Published by Elsevier Inc.
FAU - Hultman, Charles S
AU  - Hultman CS
AD  - Department of Surgery, University of North Carolina, Chapel Hill, NC, USA.
      cshult@med.unc.edu
FAU - Connolly, Annamarie
AU  - Connolly A
FAU - Halvorson, Eric G
AU  - Halvorson EG
FAU - Rowland, Pamela
AU  - Rowland P
FAU - Meyers, Michael O
AU  - Meyers MO
FAU - Mayer, David C
AU  - Mayer DC
FAU - Drake, Amelia F
AU  - Drake AF
FAU - Sheldon, George F
AU  - Sheldon GF
FAU - Meyer, Anthony A
AU  - Meyer AA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120703
PL  - United States
TA  - J Surg Res
JT  - The Journal of surgical research
JID - 0376340
SB  - IM
MH  - Adult
MH  - Curriculum
MH  - *Education, Medical
MH  - Female
MH  - Humans
MH  - Male
MH  - *Professional Role
MH  - *Professional-Patient Relations
MH  - Specialties, Surgical/*education
MH  - Students, Medical
MH  - Surveys and Questionnaires
EDAT- 2012/08/11 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/08/11 06:00
PHST- 2012/01/05 00:00 [received]
PHST- 2012/05/05 00:00 [revised]
PHST- 2012/06/14 00:00 [accepted]
PHST- 2012/08/11 06:00 [entrez]
PHST- 2012/08/11 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - S0022-4804(12)00587-2 [pii]
AID - 10.1016/j.jss.2012.06.019 [doi]
PST - ppublish
SO  - J Surg Res. 2012 Oct;177(2):217-23. doi: 10.1016/j.jss.2012.06.019. Epub 2012 Jul
      3.


PMID- 22877932
OWN - NLM
STAT- MEDLINE
DCOM- 20140418
LR  - 20131216
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 98
DP  - 2013 Dec
TI  - Ethics and images of suffering bodies in humanitarian medicine.
PG  - 278-85
LID - 10.1016/j.socscimed.2012.06.027 [doi]
LID - S0277-9536(12)00537-0 [pii]
AB  - Media representations of suffering bodies from medical humanitarian organisations
      raise ethical questions, which deserve critical attention for at least three
      reasons. Firstly, there is a normative vacuum at the intersection of medical
      ethics, humanitarian ethics and the ethics of photojournalism. Secondly, the
      perpetuation of stereotypes of illness, famine or disasters, and their political 
      derivations are a source of moral criticism, to which humanitarian medicine is
      not immune. Thirdly, accidental encounters between members of the health
      professions and members of the press in the humanitarian arena can result in
      misunderstandings and moral tension. From an ethics perspective the problem can
      be specified and better understood through two successive stages of reasoning.
      Firstly, by applying criteria of medical ethics to the concrete example of an
      advertising poster from a medical humanitarian organisation, I observe that media
      representations of suffering bodies would generally not meet ethical standards
      commonly applied in medical practice. Secondly, I try to identify what overriding
      humanitarian imperatives could outweigh such reservations. The possibility of
      action and the expression of moral outrage are two relevant humanitarian values
      which can further be spelt out through a semantic analysis of 'temoignage'
      (testimony). While the exact balance between the opposing sets of considerations 
      (medical ethics and humanitarian perspectives) is difficult to appraise,
      awareness of all values at stake is an important initial standpoint for ethical
      deliberations of media representations of suffering bodies. Future pragmatic
      approaches to the issue should include: exploring ethical values endorsed by
      photojournalism, questioning current social norms about the display of suffering,
      collecting empirical data from past or potential victims of disasters in diverse 
      cultural settings, and developing new canons with more creative or less
      problematic representations of suffering bodies than the currently accepted
      stereotypes.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Calain, Philippe
AU  - Calain P
AD  - Unite de Recherche sur les Enjeux et Pratiques Humanitaires (UREPH), Medecins
      Sans Frontieres - Switzerland, Rue de Lausanne 78, CH-1211 Geneve 21,
      Switzerland. Electronic address: philippe_calain@hotmail.com.
LA  - eng
PT  - Journal Article
DEP - 20120727
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - *Altruism
MH  - Communication
MH  - *Ethics, Medical
MH  - Humans
MH  - Journalism/*ethics
MH  - Morals
MH  - *Pain
MH  - Photography/*ethics
MH  - Relief Work/*ethics
MH  - Social Values
MH  - Stereotyping
OTO - NOTNLM
OT  - Bodies
OT  - Codes of ethics
OT  - Communications media
OT  - Images
OT  - Informed consent
OT  - Medical ethics
OT  - Non-governmental organisations
OT  - Photography
OT  - Photojournalism
OT  - Stereotyping
EDAT- 2012/08/11 06:00
MHDA- 2014/04/20 06:00
CRDT- 2012/08/11 06:00
PHST- 2012/01/27 00:00 [received]
PHST- 2012/06/12 00:00 [revised]
PHST- 2012/06/19 00:00 [accepted]
PHST- 2012/08/11 06:00 [entrez]
PHST- 2012/08/11 06:00 [pubmed]
PHST- 2014/04/20 06:00 [medline]
AID - S0277-9536(12)00537-0 [pii]
AID - 10.1016/j.socscimed.2012.06.027 [doi]
PST - ppublish
SO  - Soc Sci Med. 2013 Dec;98:278-85. doi: 10.1016/j.socscimed.2012.06.027. Epub 2012 
      Jul 27.


PMID- 22876729
OWN - NLM
STAT- MEDLINE
DCOM- 20120911
LR  - 20120810
IS  - 1040-0435 (Print)
IS  - 1040-0435 (Linking)
VI  - 24
IP  - 2
DP  - 2012 Summer
TI  - Ecological assessments of activities of daily living and personal experiences
      with Mobus, an assistive technology for cognition: a pilot study in
      schizophrenia.
PG  - 67-77
AB  - Mobus is a cognitive orthotic designed for people with difficulties managing
      Activities of Daily Living (ADL), as encountered in schizophrenia. It provides a 
      schedule manager as well as the possibility to report occurrences of symptomatic 
      experiences. Receiving this information by Internet, caregivers can assist the
      patient rehabilitation process. Our aim was to explore the use and satisfaction
      of Mobus by people with schizophrenia. Nine outpatients tested Mobus for 6 weeks.
      Indicators of cognitive functioning and autonomy were measured with the CAmbridge
      Neuropsychological Tests Automated Battery (CANTAB) and the Independant Living
      Skills Scale (ILSS). On average, 42.6% of the planned ADL were validated and more
      than 1 symptom per week were reported. Mainly because of technical breakdown,
      more than 50% of the outpatients evaluated the Mobus satisfaction below 1.7/5,
      nevertheless 3 participants appreciated it greatly. Some enhancements were found 
      on subscales of CANTAB and ILSS and some participants reported that they acquired
      planning skills by using Mobus. To ensure ease of use, refinements are needed
      from rehabilitation and technical approaches, especially to personalize the
      device. Discussions on ethical and methodological issues lead to an improved
      version of Mobus that will be tested with a larger sample size.
FAU - Sablier, Juliette
AU  - Sablier J
AD  - Neuroscience Cognitive Center CNRS UMR 5229, University of Lyon & Le Vinatier
      Hospital, France. juliette.sablier@agim.eu
FAU - Stip, Emmanuel
AU  - Stip E
FAU - Jacquet, Pierre
AU  - Jacquet P
FAU - Giroux, Sylvain
AU  - Giroux S
FAU - Pigot, Helene
AU  - Pigot H
FAU - Franck, Nicolas
AU  - Franck N
CN  - Mobus Group
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Assist Technol
JT  - Assistive technology : the official journal of RESNA
JID - 8917250
MH  - *Activities of Daily Living
MH  - Adult
MH  - *Cognition
MH  - Executive Function
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - *Self-Help Devices
MH  - *Technology Assessment, Biomedical
MH  - Young Adult
IR  - Bouchard F
FIR - Bouchard, F
IR  - Marcotte N
FIR - Marcotte, N
IR  - Viboud JP
FIR - Viboud, J P
IR  - Bentaleb LA
FIR - Bentaleb, L A
IR  - Landry P
FIR - Landry, P
IR  - Lipp O
FIR - Lipp, O
IR  - Tranulis C
FIR - Tranulis, C
IR  - Villeneuve M
FIR - Villeneuve, M
IR  - Cloutier C
FIR - Cloutier, C
IR  - Lalancette C
FIR - Lalancette, C
IR  - Prince A
FIR - Prince, A
IR  - Vincent R
FIR - Vincent, R
IR  - Lum M
FIR - Lum, M
IR  - Berrube MC
FIR - Berrube, M C
IR  - Lucas M
FIR - Lucas, M
IR  - Boisset G
FIR - Boisset, G
IR  - Guida M
FIR - Guida, M
IR  - Mazuire J
FIR - Mazuire, J
IR  - Meylan F
FIR - Meylan, F
IR  - Meynier J
FIR - Meynier, J
IR  - Pelletier G
FIR - Pelletier, G
IR  - Sportiello S
FIR - Sportiello, S
IR  - Dore-Gauthier V
FIR - Dore-Gauthier, V
IR  - Guevremont C
FIR - Guevremont, C
IR  - Nadeau-Marcotte F
FIR - Nadeau-Marcotte, F
EDAT- 2012/08/11 06:00
MHDA- 2012/09/12 06:00
CRDT- 2012/08/11 06:00
PHST- 2012/08/11 06:00 [entrez]
PHST- 2012/08/11 06:00 [pubmed]
PHST- 2012/09/12 06:00 [medline]
AID - 10.1080/10400435.2012.659324 [doi]
PST - ppublish
SO  - Assist Technol. 2012 Summer;24(2):67-77. doi: 10.1080/10400435.2012.659324.


PMID- 22876622
OWN - NLM
STAT- MEDLINE
DCOM- 20120828
LR  - 20191210
IS  - 0001-6837 (Print)
IS  - 0001-6837 (Linking)
VI  - 69
IP  - 4
DP  - 2012 Jul-Aug
TI  - Legislative and non-legislative regulations concerning Rx drug advertisement in
      the European Union and the United States--comparative analysis.
PG  - 779-87
AB  - Drug advertising is one of the most popular forms of communication between
      pharmaceutical companies and prospect drug purchasers. In the face of strong
      competition on the pharmaceutical market on the one hand, and patient's high
      susceptibility to various forms of advertising on the other, drug producers try
      to reach as wide group of recipients as possible. However, proper medicine use
      requires not only doctor's wide knowledge and experience, but also patient's
      awareness of necessity of rational drug usage. Advertising activities related to 
      this group of medicines are covered by rigorous law regulations, with taking into
      account above-mentioned issues, and other specific features of drugs available
      with prescription. The aim of this article is to present legislative and
      non-legislative regulations concerning Rx drugs, taking into consideration law
      regulations that are in force in the European Union and the United States. Ethic 
      codes implemented by drug producers associations were also used.
FAU - Czerw, Aleksandra
AU  - Czerw A
AD  - Department of Public Health, Medical University of Warsaw, 61 Zwirki i Wigury
      St., 02-091 Warszawa, Poland.
FAU - Religioni, Urszula
AU  - Religioni U
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Poland
TA  - Acta Pol Pharm
JT  - Acta poloniae pharmaceutica
JID - 2985167R
RN  - 0 (Prescription Drugs)
SB  - IM
MH  - Advertising/ethics/*legislation & jurisprudence/standards
MH  - Community Participation
MH  - Drug Industry/ethics/*legislation & jurisprudence/standards
MH  - European Union
MH  - *Government Regulation
MH  - Guidelines as Topic
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - *Legislation, Drug/ethics/standards
MH  - Marketing of Health Services/ethics/*legislation & jurisprudence/standards
MH  - Patient Education as Topic
MH  - Patient Safety
MH  - Prescription Drugs/adverse effects/standards/*therapeutic use
MH  - United States
EDAT- 2012/08/11 06:00
MHDA- 2012/08/29 06:00
CRDT- 2012/08/11 06:00
PHST- 2012/08/11 06:00 [entrez]
PHST- 2012/08/11 06:00 [pubmed]
PHST- 2012/08/29 06:00 [medline]
PST - ppublish
SO  - Acta Pol Pharm. 2012 Jul-Aug;69(4):779-87.


PMID- 22875981
OWN - NLM
STAT- MEDLINE
DCOM- 20130227
LR  - 20220408
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 12
DP  - 2012 Dec
TI  - Supporting positive experiences and sustained participation in clinical trials:
      looking beyond information provision.
PG  - 751-6
LID - 10.1136/medethics-2011-100059 [doi]
AB  - Recruitment processes for clinical trials are governed by guidelines and
      regulatory systems intended to ensure participation is informed and voluntary.
      Although the guidelines and systems provide some protection to potential
      participants, current recruitment processes often result in limited understanding
      and experiences of inadequate decision support. Many trials also have high
      drop-out rates among participants, which are ethically troubling because they can
      be indicative of poor experiences and they limit the usefulness of the knowledge 
      the trials were designed to generate. Drawing on recent social-psychological and 
      philosophical-ethical research on trial recruitment and patient participation in 
      treatment decision-making, this paper identifies possibilities for improving
      communicative support for both initial decisions and ongoing participation in
      clinical trials. It highlights the potential of a shift in thinking about
      'voluntariness', underpinned by relational understandings of autonomy, to
      encourage more nuanced judgements about the ethics of communication between trial
      staff and (potential) participants. The paper suggests that the idea of
      responsively enabling people to consider invitations or requests to participate
      in particular trials could serve as a general guide to communication. This might 
      help ensure decisions about trial participation are meaningfully informed and
      voluntary, and that relationships between trial staff and participants contribute
      to positive experiences of trial participation and ultimately to the generation
      of the robust knowledge.
FAU - Gillies, Kate
AU  - Gillies K
AD  - Social Dimensions of Health Institute, University of Dundee, 11 Airlie Place,
      Dundee DD1 4HJ, UK.
FAU - Entwistle, Vikki A
AU  - Entwistle VA
LA  - eng
GR  - HSRU2/CSO_/Chief Scientist Office/United Kingdom
GR  - PDF/09/01/CSO_/Chief Scientist Office/United Kingdom
PT  - Journal Article
DEP - 20120808
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Choice Behavior
MH  - Clinical Trials as Topic/*ethics/standards
MH  - Comprehension
MH  - *Decision Making
MH  - Human Experimentation/ethics
MH  - Humans
MH  - Information Dissemination
MH  - Informed Consent/*ethics/psychology/standards
MH  - Negotiating
MH  - *Patient Participation/psychology
MH  - Patient Selection/*ethics
MH  - *Research Subjects/psychology
EDAT- 2012/08/10 06:00
MHDA- 2013/02/28 06:00
CRDT- 2012/08/10 06:00
PHST- 2012/08/10 06:00 [entrez]
PHST- 2012/08/10 06:00 [pubmed]
PHST- 2013/02/28 06:00 [medline]
AID - medethics-2011-100059 [pii]
AID - 10.1136/medethics-2011-100059 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Dec;38(12):751-6. doi: 10.1136/medethics-2011-100059. Epub
      2012 Aug 8.


PMID- 22875798
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20170922
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 265
IP  - 1
DP  - 2012 Oct
TI  - Radiation dose and cataract surgery incidence in atomic bomb survivors,
      1986-2005.
PG  - 167-74
AB  - PURPOSE: To examine the incidence of clinically important cataracts in relation
      to lens radiation doses between 0 and approximately 3 Gy to address risks at
      relatively low brief doses. MATERIALS AND METHODS: Informed consent was obtained,
      and human subjects procedures were approved by the ethical committee at the
      Radiation Effects Research Foundation. Cataract surgery incidence was documented 
      for 6066 atomic bomb survivors during 1986-2005. Sixteen risk factors for
      cataract, such as smoking, hypertension, and corticosteroid use, were not
      confounders of the radiation effect on the basis of Cox regression analysis.
      Radiation dose-response analyses were performed for cataract surgery incidence by
      using Poisson regression analysis, adjusting for demographic variables and
      diabetes mellitus, and results were expressed as the excess relative risk (ERR)
      and the excess absolute risk (EAR) (ie, measures of how much radiation multiplies
      [ERR] or adds to [EAR] the risk in the unexposed group). RESULTS: Of 6066 atomic 
      bomb survivors, 1028 underwent a first cataract surgery during 1986-2005. The
      estimated threshold dose was 0.50 Gy (95% confidence interval [CI]: 0.10 Gy, 0.95
      Gy) for the ERR model and 0.45 Gy (95% CI: 0.10 Gy, 1.05 Gy) for the EAR model. A
      linear-quadratic test for upward curvature did not show a significant quadratic
      effect for either the ERR or EAR model. The linear ERR model for a 70-year-old
      individual, exposed at age 20 years, showed a 0.32 (95% CI: 0.09, 0.53)
      [corrected] excess risk at 1 Gy. The ERR was highest for those who were young at 
      exposure. CONCLUSION: These data indicate a radiation effect for vision-impairing
      cataracts at doses less than 1 Gy. The evidence suggests that dose standards for 
      protection of the eye from brief radiation exposures should be 0.5 Gy or less.
CI  - (c) RSNA, 2012.
FAU - Neriishi, Kazuo
AU  - Neriishi K
AD  - Department of Clinical Studies, Radiation Effects Research Foundation, 5-2
      Hijiyama Park, Minami-ku, Hiroshima 732-0815, Japan. neriishi@rerf.or.jp
FAU - Nakashima, Eiji
AU  - Nakashima E
FAU - Akahoshi, Masazumi
AU  - Akahoshi M
FAU - Hida, Ayumi
AU  - Hida A
FAU - Grant, Eric J
AU  - Grant EJ
FAU - Masunari, Naomi
AU  - Masunari N
FAU - Funamoto, Sachiyo
AU  - Funamoto S
FAU - Minamoto, Atsushi
AU  - Minamoto A
FAU - Fujiwara, Saeko
AU  - Fujiwara S
FAU - Shore, Roy E
AU  - Shore RE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120808
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
CIN - Strahlenther Onkol. 2013 Mar;189(3):264-5. PMID: 23319254
EIN - Radiology. 2012 Dec;265(3):981
MH  - Aged
MH  - Aged, 80 and over
MH  - Cataract/*epidemiology
MH  - Cataract Extraction/*statistics & numerical data
MH  - Dose-Response Relationship, Radiation
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Japan/epidemiology
MH  - Male
MH  - Middle Aged
MH  - *Nuclear Weapons
MH  - Poisson Distribution
MH  - Proportional Hazards Models
MH  - Risk Factors
MH  - *Survivors
EDAT- 2012/08/10 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/08/10 06:00
PHST- 2012/08/10 06:00 [entrez]
PHST- 2012/08/10 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - radiol.12111947 [pii]
AID - 10.1148/radiol.12111947 [doi]
PST - ppublish
SO  - Radiology. 2012 Oct;265(1):167-74. doi: 10.1148/radiol.12111947. Epub 2012 Aug 8.


PMID- 22875797
OWN - NLM
STAT- MEDLINE
DCOM- 20130103
LR  - 20220311
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 265
IP  - 2
DP  - 2012 Nov
TI  - Hippocampal calcification prevalence at CT: a retrospective review.
PG  - 504-10
LID - 10.1148/radiol.12110636 [doi]
AB  - PURPOSE: To determine the prevalence of intrahippocampal calcification at brain
      computed tomography (CT), evaluate any association with calcification involving
      the intracranial arteries or lentiform nuclei, and assess the clinical importance
      of intrahippocampal calcification. MATERIALS AND METHODS: Study approval was
      obtained by the Southern Health Human Research Ethics Committee, which waived the
      requirement for informed consent because of the retrospective nature of the
      study. The presence of intrahippocampal calcification was assessed by four
      readers through retrospective review of 300 randomly selected nonenhanced brain
      CT scans. In addition, the presence of calcification involving the intracranial
      arteries and lentiform nuclei was assessed, and the clinical histories were
      reviewed in those patients with intrahippocampal calcifications and a matched
      control cohort without intrahippocampal calcification. Differences in proportion 
      of patients with intrahippocampal calcifications across different age groups were
      assessed by using chi2 analysis. Interrater agreement and intrarater agreement
      were assessed by using kappa analysis. RESULTS: Intrahippocampal calcification
      was demonstrated in 47 (15.7%) of 300 patients, and 47 (21.7%) of 217 patients
      older than 50 years of age. Its prevalence increased with age (P=.008). All
      patients with intrahippocampal calcification and the control cohort demonstrated 
      calcification involving the intracranial arteries. Eleven (23.4%) of 47 patients 
      with intrahippocampal calcification had calcification within the lentiform nuclei
      compared with 14 (29.8%) of 47 in the control cohort (P=.67). The anatomic
      distribution of intrahippocampal calcification was similar to that described in
      vascular fibrosis and calcification. CONCLUSION: The prevalence of
      intrahippocampal calcification appears to increase with age and is a relatively
      common finding in patients older than 50 years. It has a similar anatomic
      distribution to microscopic vascular fibrosis and calcification and likely
      reflects its latter stages.
CI  - (c) RSNA, 2012
FAU - Chew, Angus P T
AU  - Chew AP
AD  - Department of Diagnostic Imaging, Southern Health, 246 Clayton Rd, Clayton, VIC
      3168, Australia. angus.chew@southernhealth.org.au
FAU - Gupta, Gaurav
AU  - Gupta G
FAU - Alatakis, Steven
AU  - Alatakis S
FAU - Schneider-Kolsky, Michal
AU  - Schneider-Kolsky M
FAU - Stuckey, Stephen L
AU  - Stuckey SL
LA  - eng
PT  - Journal Article
DEP - 20120808
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain Diseases/*diagnostic imaging/*epidemiology
MH  - Calcinosis/*diagnostic imaging/*epidemiology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Hippocampus/*diagnostic imaging
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Retrospective Studies
MH  - Tomography, X-Ray Computed/*statistics & numerical data
MH  - Victoria/epidemiology
MH  - Young Adult
EDAT- 2012/08/10 06:00
MHDA- 2013/01/04 06:00
CRDT- 2012/08/10 06:00
PHST- 2012/08/10 06:00 [entrez]
PHST- 2012/08/10 06:00 [pubmed]
PHST- 2013/01/04 06:00 [medline]
AID - radiol.12110636 [pii]
AID - 10.1148/radiol.12110636 [doi]
PST - ppublish
SO  - Radiology. 2012 Nov;265(2):504-10. doi: 10.1148/radiol.12110636. Epub 2012 Aug 8.


PMID- 22875390
OWN - NLM
STAT- MEDLINE
DCOM- 20130110
LR  - 20120809
IS  - 1098-9048 (Electronic)
IS  - 1069-3424 (Linking)
VI  - 33
IP  - 4
DP  - 2012 Aug
TI  - The brave new world revealed: wrestling with reality, rationing, and rationality.
PG  - 427-30
LID - 10.1055/s-0032-1322413 [doi]
AB  - When Dr. Joseph Lynch, editor of Seminars in Respiratory and Critical Care
      Medicine, invited us to organize and edit this topic we-and our contributors-were
      initially baffled about how we could marry outcomes, ethics, and economics. His
      perspective as an elder-statesman, who has observed the evolution of critical
      care medicine over 4 decades, provided perspective as to how these three areas
      are intimately related and that their synthesis is essential if the US medical
      system is to best serve our populace as resources become increasingly limited.
CI  - Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
FAU - Manthous, Constantine A
AU  - Manthous CA
AD  - Department of Medicine, Yale University School of Medicine, New Haven,
      Connecticut, USA. manthous@sbcglobal.net
FAU - White, Douglas B
AU  - White DB
FAU - Carson, Shannon S
AU  - Carson SS
LA  - eng
PT  - Editorial
DEP - 20120808
PL  - United States
TA  - Semin Respir Crit Care Med
JT  - Seminars in respiratory and critical care medicine
JID - 9431858
SB  - IM
MH  - Critical Care/*economics/ethics
MH  - *Ethics, Medical
MH  - Health Care Rationing/*economics/ethics
MH  - Humans
EDAT- 2012/08/10 06:00
MHDA- 2013/01/11 06:00
CRDT- 2012/08/10 06:00
PHST- 2012/08/10 06:00 [entrez]
PHST- 2012/08/10 06:00 [pubmed]
PHST- 2013/01/11 06:00 [medline]
AID - 10.1055/s-0032-1322413 [doi]
PST - ppublish
SO  - Semin Respir Crit Care Med. 2012 Aug;33(4):427-30. doi: 10.1055/s-0032-1322413.
      Epub 2012 Aug 8.


PMID- 22875389
OWN - NLM
STAT- MEDLINE
DCOM- 20130110
LR  - 20120809
IS  - 1098-9048 (Electronic)
IS  - 1069-3424 (Linking)
VI  - 33
IP  - 4
DP  - 2012 Aug
TI  - The physician as rationer: uncertainty about the physician's role obligations.
PG  - 421-6
LID - 10.1055/s-0032-1322412 [doi]
AB  - Although the need to ration health care is increasingly accepted, the need for
      bedside physicians to participate in it is not. There are three common
      perspectives on physicians' roles in rationing: one is that bedside physicians
      should advocate fully for their patients and eschew rationing; another is that
      some rationing is permissible but should be imposed from outside the
      patient-physician relationship; the third is that bedside physicians should
      simultaneously advocate for their individual patients and make bedside rationing 
      decisions that incorporate societal interests. The first two conceptualizations
      are at odds with empirical evidence that physicians do ration at the bedside and 
      the idea that doing so may be a necessary part of efforts to control costs,
      whereas the third raises difficult ethical questions about the extent of
      physicians' obligations to advocate maximally for their individual patients.
CI  - Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
FAU - Scheunemann, Leslie P
AU  - Scheunemann LP
AD  - Division of Pulmonary, Allergy, and Critical Care Medicine, University of
      Pittsburgh Medical Center, Pittsburgh, PA 15213, USA. scheunemannlp@upmc.edu
FAU - White, Douglas B
AU  - White DB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120808
PL  - United States
TA  - Semin Respir Crit Care Med
JT  - Seminars in respiratory and critical care medicine
JID - 9431858
SB  - IM
MH  - American Medical Association
MH  - Conflict of Interest
MH  - Decision Making/*ethics
MH  - *Ethics, Medical
MH  - Health Care Rationing/economics/*ethics/standards
MH  - Humans
MH  - Patient Advocacy/*ethics/standards
MH  - *Physician's Role
MH  - Physician-Patient Relations/*ethics
MH  - Physicians/*ethics/standards
MH  - United States
EDAT- 2012/08/10 06:00
MHDA- 2013/01/11 06:00
CRDT- 2012/08/10 06:00
PHST- 2012/08/10 06:00 [entrez]
PHST- 2012/08/10 06:00 [pubmed]
PHST- 2013/01/11 06:00 [medline]
AID - 10.1055/s-0032-1322412 [doi]
PST - ppublish
SO  - Semin Respir Crit Care Med. 2012 Aug;33(4):421-6. doi: 10.1055/s-0032-1322412.
      Epub 2012 Aug 8.


PMID- 22875388
OWN - NLM
STAT- MEDLINE
DCOM- 20130110
LR  - 20120809
IS  - 1098-9048 (Electronic)
IS  - 1069-3424 (Linking)
VI  - 33
IP  - 4
DP  - 2012 Aug
TI  - Cost-effective critical care: cost containment and rationing.
PG  - 413-20
LID - 10.1055/s-0032-1322411 [doi]
AB  - Rationing occurs whenever the demand for a good or service exceeds its supply.
      Therefore rationing is an inevitable occurrence in medicine and in critical care 
      where the potential demand for effective medical care will exceed supply.
      Although there are many strategies to allocate medical resources one that is
      often considered is based on cost-effectiveness. Cost-effectiveness analysis
      attempts to estimate the value of individual medical treatments in terms of
      dollars and outcomes. Allocation of medical treatments based on
      cost-effectiveness analysis requires valid estimates of both the costs and the
      effectiveness of treatments as well as some overarching body with the authority
      to enforce allocation based on these analyses. Limitations of allocation based on
      cost-effectiveness analysis in critical care include difficulties in estimating
      marginal costs of critical care treatments, limited evidence for any treatments
      with efficacy, and the ethical principle of rescuing identifiable lives in
      imminent risk of death. The prospect of a pandemic influenza-like infection has
      stimulated a lot of interest in hypothetical rationing strategies for the
      intensive care unit, none of which has been tested in actual pandemic scenarios. 
      Given the burden of critical illness and the wide variation in resources a global
      approach to rationing is untenable. The article concludes with a vision of the
      future of allocation in critical care.
CI  - Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
FAU - Rubenfeld, Gordon D
AU  - Rubenfeld GD
AD  - Department of Medicine, University of Toronto School of Medicine, Toronto,
      Ontario, Canada. gordon.rubenfeld@sunnybrook.ca
LA  - eng
PT  - Journal Article
DEP - 20120808
PL  - United States
TA  - Semin Respir Crit Care Med
JT  - Seminars in respiratory and critical care medicine
JID - 9431858
SB  - IM
MH  - Cost Control/methods
MH  - Cost-Benefit Analysis
MH  - Critical Care/*economics/ethics
MH  - Decision Making
MH  - Disasters/economics
MH  - Health Care Costs
MH  - Health Care Rationing/*economics/ethics
MH  - Humans
MH  - Intensive Care Units/economics
MH  - Pandemics/economics
EDAT- 2012/08/10 06:00
MHDA- 2013/01/11 06:00
CRDT- 2012/08/10 06:00
PHST- 2012/08/10 06:00 [entrez]
PHST- 2012/08/10 06:00 [pubmed]
PHST- 2013/01/11 06:00 [medline]
AID - 10.1055/s-0032-1322411 [doi]
PST - ppublish
SO  - Semin Respir Crit Care Med. 2012 Aug;33(4):413-20. doi: 10.1055/s-0032-1322411.
      Epub 2012 Aug 8.


PMID- 22875387
OWN - NLM
STAT- MEDLINE
DCOM- 20130110
LR  - 20181201
IS  - 1098-9048 (Electronic)
IS  - 1069-3424 (Linking)
VI  - 33
IP  - 4
DP  - 2012 Aug
TI  - Intensivist time allocation: economic and ethical issues surrounding how
      intensivists use their time.
PG  - 401-12
LID - 10.1055/s-0032-1322410 [doi]
AB  - Intensivists' time is a fundamentally constrained resource. Many factors can put 
      intensivists under conditions in which demands for their time outstrip the amount
      of time available. The importance of intensivist time strain is increasing both
      because demand for intensivists exceeds supply and because the roles that
      intensivists are being asked to take on are constantly expanding. There is strong
      evidence that time strain affects the decisions that intensivists make; evidence 
      about whether it impacts patient outcomes is mixed. In deciding how to allocate
      their time, intensivists face many challenges. This article highlights two of
      these challenges: (1) How should intensivists approach two common
      scheduling-related issues (24/7 intensive care unit coverage and long blocks of
      service time that promote continuity but sacrifice weekends off) and balance
      these issues with the very real workforce concern of accelerated professional
      burnout? (2) What are the hidden financial impacts of intensivist participation
      in quality improvement programs, given current reimbursement systems?
CI  - Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
FAU - Howell, Michael D
AU  - Howell MD
AD  - Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine,
      Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
      mhowell@bidmc.harvard.edu
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120808
PL  - United States
TA  - Semin Respir Crit Care Med
JT  - Seminars in respiratory and critical care medicine
JID - 9431858
SB  - IM
MH  - Burnout, Professional
MH  - Hospital Mortality
MH  - Humans
MH  - *Intensive Care Units/economics/ethics
MH  - Models, Organizational
MH  - Personnel Staffing and Scheduling/*economics/statistics & numerical data
MH  - Quality of Health Care/*economics
MH  - Reimbursement Mechanisms/*economics
MH  - Time Management
MH  - Workforce
MH  - Workload/psychology
EDAT- 2012/08/10 06:00
MHDA- 2013/01/11 06:00
CRDT- 2012/08/10 06:00
PHST- 2012/08/10 06:00 [entrez]
PHST- 2012/08/10 06:00 [pubmed]
PHST- 2013/01/11 06:00 [medline]
AID - 10.1055/s-0032-1322410 [doi]
PST - ppublish
SO  - Semin Respir Crit Care Med. 2012 Aug;33(4):401-12. doi: 10.1055/s-0032-1322410.
      Epub 2012 Aug 8.


PMID- 22875385
OWN - NLM
STAT- MEDLINE
DCOM- 20130110
LR  - 20120809
IS  - 1098-9048 (Electronic)
IS  - 1069-3424 (Linking)
VI  - 33
IP  - 4
DP  - 2012 Aug
TI  - The ethical and economic impact of defaults.
PG  - 382-92
LID - 10.1055/s-0032-1322402 [doi]
AB  - Medical care offered to the critically ill often occurs by default, unfolding
      automatically unless concerted effort is made to do otherwise. In their scope,
      defaults include traditional approaches to treatment and decision making, as well
      as policies deliberately set to promote specific health outcomes. Defaults are
      ethically sound to the extent that they foster patient well-being and autonomy.
      Unfortunately in practice, some defaults lead to ineffective, unwanted, and
      expensive care. This article reviews the ethical and economic impact of defaults,
      paying special attention to their influence on the practice of cardiopulmonary
      resuscitation and admission to the intensive care unit.
CI  - Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
FAU - Siegel, Mark D
AU  - Siegel MD
AD  - Department of Internal Medicine, Section of Pulmonary and Critical Care Medicine,
      Yale University School of Medicine, New Haven, CT 06520-8057, USA.
      mark.siegel@yale.edu
FAU - Stapleton, Renee
AU  - Stapleton R
FAU - Wunsch, Hannah
AU  - Wunsch H
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120808
PL  - United States
TA  - Semin Respir Crit Care Med
JT  - Seminars in respiratory and critical care medicine
JID - 9431858
SB  - IM
MH  - Cardiopulmonary Resuscitation/economics/*ethics/mortality
MH  - Critical Illness/*economics/mortality
MH  - Decision Making/*ethics
MH  - *Ethics, Medical
MH  - Humans
MH  - Intensive Care Units/organization & administration
MH  - Postoperative Care/economics
EDAT- 2012/08/10 06:00
MHDA- 2013/01/11 06:00
CRDT- 2012/08/10 06:00
PHST- 2012/08/10 06:00 [entrez]
PHST- 2012/08/10 06:00 [pubmed]
PHST- 2013/01/11 06:00 [medline]
AID - 10.1055/s-0032-1322402 [doi]
PST - ppublish
SO  - Semin Respir Crit Care Med. 2012 Aug;33(4):382-92. doi: 10.1055/s-0032-1322402.
      Epub 2012 Aug 8.


PMID- 22875377
OWN - NLM
STAT- MEDLINE
DCOM- 20130110
LR  - 20120809
IS  - 1098-9048 (Electronic)
IS  - 1069-3424 (Linking)
VI  - 33
IP  - 4
DP  - 2012 Aug
TI  - Intersection of outcomes, ethics, and economics in critical care.
PG  - 325
LID - 10.1055/s-0032-1322409 [doi]
FAU - Manthous, Constantine A
AU  - Manthous CA
AD  - Department of Medicine, Yale University School of Medicine, New Haven,
      Connecticut, USA. manthous@sbcglobal.net
FAU - White, Douglas B
AU  - White DB
FAU - Carson, Shannon S
AU  - Carson SS
LA  - eng
PT  - Introductory Journal Article
DEP - 20120808
PL  - United States
TA  - Semin Respir Crit Care Med
JT  - Seminars in respiratory and critical care medicine
JID - 9431858
SB  - IM
MH  - Critical Care/*economics
MH  - Health Care Rationing/ethics
MH  - Humans
MH  - Medicare/economics/trends
MH  - United States
EDAT- 2012/08/10 06:00
MHDA- 2013/01/11 06:00
CRDT- 2012/08/10 06:00
PHST- 2012/08/10 06:00 [entrez]
PHST- 2012/08/10 06:00 [pubmed]
PHST- 2013/01/11 06:00 [medline]
AID - 10.1055/s-0032-1322409 [doi]
PST - ppublish
SO  - Semin Respir Crit Care Med. 2012 Aug;33(4):325. doi: 10.1055/s-0032-1322409. Epub
      2012 Aug 8.


PMID- 22875356
OWN - NLM
STAT- MEDLINE
DCOM- 20120911
LR  - 20120809
IS  - 0966-0461 (Print)
IS  - 0966-0461 (Linking)
VI  - 21
IP  - 11
DP  - 2012 Jun 14-27
TI  - Final-year student nurses' perceptions of role transition.
PG  - 684-8
AB  - Role transition can be both challenging and exciting. This study presents the
      findings of phase one of a two-part study conducted by Deasy et al (2011), which 
      explored final-year student nurses' (n=116) perceptions and expectations of role 
      transition. The students were registered on four-year BSc nursing programmes at
      an Irish university. Data was analyzed using SPSS (version 16). A response rate
      of 84% was achieved. Over half of respondents said they were adequately prepared 
      for the post of registered nurse. Respondents generally perceived themselves to
      be competent across a range of domains: managing workloads; prioritizing care
      delivery; interpersonal skills; time management skills; ethical decision making; 
      and providing health information and education. In contrast, not all were
      confident about their knowledge and many expected the transition to be
      problematic. Most expected to be supported and to receive constructive feedback. 
      Recommendations include nurturing supportive work environments to reduce stress
      and increase confidence.
FAU - Doody, Owen
AU  - Doody O
AD  - Department of Nursing and Midwifery, University of Limerick.
FAU - Tuohy, Dympna
AU  - Tuohy D
FAU - Deasy, Christine
AU  - Deasy C
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Nurs
JT  - British journal of nursing (Mark Allen Publishing)
JID - 9212059
MH  - *Adaptation, Psychological
MH  - *Attitude of Health Personnel
MH  - Clinical Competence
MH  - Female
MH  - Humans
MH  - Interprofessional Relations
MH  - Male
MH  - Nurse's Role/*psychology
MH  - Nursing Staff/*psychology/standards
MH  - Students, Nursing/*psychology
MH  - Young Adult
EDAT- 2012/08/10 06:00
MHDA- 2012/09/12 06:00
CRDT- 2012/08/10 06:00
PHST- 2012/08/10 06:00 [entrez]
PHST- 2012/08/10 06:00 [pubmed]
PHST- 2012/09/12 06:00 [medline]
AID - 10.12968/bjon.2012.21.11.684 [doi]
PST - ppublish
SO  - Br J Nurs. 2012 Jun 14-27;21(11):684-8. doi: 10.12968/bjon.2012.21.11.684.


PMID- 22874862
OWN - NLM
STAT- MEDLINE
DCOM- 20121024
LR  - 20181201
IS  - 0966-0461 (Print)
IS  - 0966-0461 (Linking)
VI  - 21
IP  - 15
DP  - 2012 Aug 9-Sep 12
TI  - Medication administration practices among children's nurses: a survey.
PG  - 928-33
AB  - AIM AND OBJECTIVES: The overall aim of this study was to investigate the
      medication administration practices of children's nurses. The specific objective 
      was to identify practices that may improve the medication administration process,
      where necessary. DESIGN: Using a non-experimental survey design, a 'Medication
      Administration Practices Survey' was developed for use in this study. The survey 
      was designed to include questions based on medication administration practices
      and not solely on medication errors. Ethical approval was obtained from the local
      research ethics committee where data were collected. All clinical staff working
      in all areas in a children's hospital were included. RESULTS: Interruptions in
      the medication process, a heavy workload and fatigue were some of the findings
      that emerged from this study. Inadequate knowledge and skills and a failure to
      comply with hospital policy were also identified. CONCLUSION: A lack of adherence
      to hospital policy and the frequency of interruptions in the medication
      administration process are important practices that require change as indicated
      by this study. Several recommendations are made, directed toward preventing or
      reducing medication errors and supporting children's nurses in providing best
      practice.
FAU - Murphy, Maryanne
AU  - Murphy M
AD  - Trinity College, Dublin.
FAU - While, Alison
AU  - While A
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Nurs
JT  - British journal of nursing (Mark Allen Publishing)
JID - 9212059
RN  - 0 (Pharmaceutical Preparations)
MH  - Data Collection
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Medication Errors
MH  - *Nursing Staff, Hospital
MH  - Organizational Policy
MH  - *Pediatric Nursing
MH  - Pharmaceutical Preparations/*administration & dosage
MH  - Pharmacists
MH  - Professional Role
MH  - Workforce
EDAT- 2012/08/10 06:00
MHDA- 2012/10/25 06:00
CRDT- 2012/08/10 06:00
PHST- 2012/08/10 06:00 [entrez]
PHST- 2012/08/10 06:00 [pubmed]
PHST- 2012/10/25 06:00 [medline]
AID - 10.12968/bjon.2012.21.15.928 [doi]
PST - ppublish
SO  - Br J Nurs. 2012 Aug 9-Sep 12;21(15):928-33. doi: 10.12968/bjon.2012.21.15.928.


PMID- 22874630
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 4
DP  - 2012
TI  - Case stories in general practice: a focus group study.
LID - 10.1136/bmjopen-2012-001208 [doi]
LID - e001208 [pii]
AB  - OBJECTIVES: To explore the interactive process of sharing case stories in
      small-group activity in general practice. DESIGN: Qualitative focus group study. 
      SETTING: Peer-group meetings of doctors attending specialist training or
      continuous medical education in general practice. PARTICIPANTS: Twenty female and
      30 male doctors working in general practice in Norway. RESULTS: The storyline of 
      case presentations included detailed stories with emotional engagement,
      co-authored by other group members. The stories initiated discussions and
      reflections concerning patients' and doctors' perspectives, medical ethics as
      well as clinical problems. The safe atmosphere allowed testing out boundaries of 
      socially shared knowledge. CONCLUSIONS: Sharing case stories in small groups in
      general practice initiated interaction that facilitated meaning-making,
      reflection and peer support.
FAU - Abildsnes, Eirik
AU  - Abildsnes E
AD  - Department of Public Health and Primary Health Care, University of Bergen,
      Bergen, Norway.
FAU - Flottorp, Signe
AU  - Flottorp S
FAU - Stensland, Per
AU  - Stensland P
LA  - eng
PT  - Journal Article
DEP - 20120808
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3425945
EDAT- 2012/08/10 06:00
MHDA- 2012/08/10 06:01
CRDT- 2012/08/10 06:00
PHST- 2012/08/10 06:00 [entrez]
PHST- 2012/08/10 06:00 [pubmed]
PHST- 2012/08/10 06:01 [medline]
AID - bmjopen-2012-001208 [pii]
AID - 10.1136/bmjopen-2012-001208 [doi]
PST - epublish
SO  - BMJ Open. 2012 Aug 8;2(4). pii: bmjopen-2012-001208. doi:
      10.1136/bmjopen-2012-001208. Print 2012.


PMID- 22874487
OWN - NLM
STAT- MEDLINE
DCOM- 20130103
LR  - 20131121
IS  - 0040-5957 (Print)
IS  - 0040-5957 (Linking)
VI  - 67
IP  - 3
DP  - 2012 May-Jun
TI  - [Neuroenhancement in healthy subject? A French case study].
PG  - 213-21
LID - 10.2515/therapie/2012026 [doi]
AB  - Neuroenhancement is an anglo-saxon concept concerning the use of stimulating
      psychotropic drugs by healthy subjects, outside any established medical
      indication or festive setting, to achieve an improvement of their mental
      functioning. In 2009, because of increasing requests for neuroenhancement in USA,
      the American Association of Neurology has published practical recommendations
      stating that "it is ethically permissible to prescribe medications for
      neuroenhancement" if a number of conditions is met. We present these ethical and 
      psychopharmacological conditions ("the inverted U-Shape principle" in which
      cognitive performance is related to catecholamine levels and "the trade-off
      principle" to cognitive enhancement) through a clinical case of methylphenidate
      prescription in a healthy 24 years old medical student, preparing for the "examen
      classant national" (the French national ranking before postgraduate education).
      We then discuss anglo-saxon ethical context in which these recommendations have
      been proposed.
CI  - (c) 2012 Societe Francaise de Pharmacologie et de Therapeutique.
FAU - Micoulaud-Franchi, Jean-Arthur
AU  - Micoulaud-Franchi JA
AD  - Pole de Psychiatrie Solaris, Centre Hospitalier Universitaire de
      Sainte-Marguerite, Marseille, France. jarthur.micoulaud@gmail.com
FAU - Vion-Dury, Jean
AU  - Vion-Dury J
FAU - Lancon, Christophe
AU  - Lancon C
LA  - fre
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - Peut-on prescrire des psychostimulants chez un etudiant sain? Exemple d'un cas
      clinique.
DEP - 20120809
PL  - France
TA  - Therapie
JT  - Therapie
JID - 0420544
RN  - 0 (Catecholamines)
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Nootropic Agents)
RN  - 207ZZ9QZ49 (Methylphenidate)
SB  - IM
MH  - Catecholamines/metabolism
MH  - Central Nervous System Stimulants/*pharmacology
MH  - Cognition/drug effects
MH  - Ethics, Medical
MH  - France/epidemiology
MH  - Humans
MH  - Male
MH  - Mental Processes/*drug effects
MH  - Methylphenidate/therapeutic use
MH  - Nootropic Agents/*pharmacology
MH  - Psychomotor Performance/drug effects
MH  - Students, Medical
MH  - Young Adult
EDAT- 2012/08/10 06:00
MHDA- 2013/01/04 06:00
CRDT- 2012/08/10 06:00
PHST- 2011/07/28 00:00 [received]
PHST- 2012/03/06 00:00 [accepted]
PHST- 2012/08/10 06:00 [entrez]
PHST- 2012/08/10 06:00 [pubmed]
PHST- 2013/01/04 06:00 [medline]
AID - 10.2515/therapie/2012026 [doi]
AID - th122014 [pii]
PST - ppublish
SO  - Therapie. 2012 May-Jun;67(3):213-21. doi: 10.2515/therapie/2012026. Epub 2012 Aug
      9.


PMID- 22874293
OWN - NLM
STAT- MEDLINE
DCOM- 20130122
LR  - 20120809
IS  - 0926-9630 (Print)
IS  - 0926-9630 (Linking)
VI  - 180
DP  - 2012
TI  - Towards human-centric visual access control for clinical data management.
PG  - 756-60
AB  - We propose a novel human-centric, visual, and context-aware access control (AC)
      system for distributed clinical data management and health information systems.
      Human-centricity in this context means that medical staff should be able to
      configure AC rules, both in a timesaving and reliable manner. Since medical data 
      often includes (meta-) information about a patient, it is essential that an AC
      system includes the patient into the AC process. To cater for the strong security
      needs in the medical domain, both the AC policy creation by medical staff as well
      as the patient-interaction feature need to be taken into account. While
      traditional AC systems offer sufficient security in theory, they lack in comfort 
      and flexibility and as a result find no widespread acceptance with non tech-savvy
      users. Distributed medical institutions could enormously benefit from the
      opportunity of dynamic AC configuration at an end-user level while adhering to
      legal, ethical or other privacy requirements. Hence, this paper presents a
      human-centric visual AC model for medical data, addressing usability, information
      security and patient interaction.
FAU - Fahl, Sascha
AU  - Fahl S
AD  - Leibniz University Hannover, Distributed Computing & Security Group, Germany.
      fahl@dcsec.uni-hannover.de
FAU - Harbach, Marian
AU  - Harbach M
FAU - Smith, Matthew
AU  - Smith M
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Stud Health Technol Inform
JT  - Studies in health technology and informatics
JID - 9214582
MH  - *Data Display
MH  - *Database Management Systems
MH  - *Electronic Health Records
MH  - Germany
MH  - *Health Records, Personal
MH  - Information Storage and Retrieval/*methods
MH  - Knowledge Management
MH  - *Man-Machine Systems
MH  - *User-Computer Interface
EDAT- 2012/08/10 06:00
MHDA- 2013/01/23 06:00
CRDT- 2012/08/10 06:00
PHST- 2012/08/10 06:00 [entrez]
PHST- 2012/08/10 06:00 [pubmed]
PHST- 2013/01/23 06:00 [medline]
PST - ppublish
SO  - Stud Health Technol Inform. 2012;180:756-60.


PMID- 22874264
OWN - NLM
STAT- MEDLINE
DCOM- 20130122
LR  - 20120809
IS  - 0926-9630 (Print)
IS  - 0926-9630 (Linking)
VI  - 180
DP  - 2012
TI  - Secondary use of clinical data in healthcare providers - an overview on research,
      regulatory and ethical requirements.
PG  - 614-8
AB  - Hospital providers, physicians and researchers are interested in a
      cross-institutional use of their data for clinical research. This interest has
      led to the question whether the scientific potential of the data stored in so
      many different systems can be unfolded by the establishment of a
      cross-institutional medical data warehouse. The aim of this paper is to describe 
      the ethical and regulatory requirements and to develop a solution architecture
      considering technical and organisational aspects. The present paper uses a
      structured approach to collect user requirements. The requirements are discussed 
      with legal experts. The work was complemented by extended literature research. An
      essential requirement is the cross-institutional merging of the data. Here,
      aspects of data protection as the informed consent, or transparency must be
      considered. In addition it is essential to protect the researchers through
      transparency from accusations on publication bias. Technical and organisational
      solutions in combination of data protection, and data security enable an
      operation of a central medical data warehouse in compliance with the law. The
      usage of this infrastructure for research can contribute to an improvement of the
      treatment quality, and patient safety if there is an appropriate transparency.
      This contributes to innovation and added value of a hospital group.
FAU - Wiesenauer, Matthias
AU  - Wiesenauer M
AD  - IT-Department, RHON-KLINIKUM AG, Bad Neustadt Saale, Germany.
FAU - Johner, Christian
AU  - Johner C
FAU - Rohrig, Rainer
AU  - Rohrig R
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Stud Health Technol Inform
JT  - Studies in health technology and informatics
JID - 9214582
MH  - Biomedical Research/*ethics/*legislation & jurisprudence
MH  - Confidentiality/*ethics/*legislation & jurisprudence
MH  - Germany
MH  - Government Regulation
MH  - Health Personnel/*ethics
MH  - Medical Informatics/*ethics/*legislation & jurisprudence
EDAT- 2012/08/10 06:00
MHDA- 2013/01/23 06:00
CRDT- 2012/08/10 06:00
PHST- 2012/08/10 06:00 [entrez]
PHST- 2012/08/10 06:00 [pubmed]
PHST- 2013/01/23 06:00 [medline]
PST - ppublish
SO  - Stud Health Technol Inform. 2012;180:614-8.


PMID- 22874085
OWN - NLM
STAT- MEDLINE
DCOM- 20130604
LR  - 20211021
IS  - 1549-490X (Electronic)
IS  - 1083-7159 (Linking)
VI  - 17
IP  - 11
DP  - 2012
TI  - Truth-telling and cancer diagnoses: physician attitudes and practices in Qatar.
PG  - 1469-74
LID - 10.1634/theoncologist.2012-0128 [doi]
AB  - There is limited information regarding physicians' attitudes toward revealing
      cancer diagnoses to patients in the Arab world. Using a questionnaire informed by
      a seminal study carried out by Oken in 1961, our research sought to determine
      present-day disclosure practices in Qatar, identify physician sociodemographic
      variables associated with truth-telling, and outline trends related to future
      practice. A sample of 131 physicians was polled. Although nearly 90% of doctors
      said they would inform cancer patients of their diagnosis, approximately 66% of
      respondents stated that they made exceptions to their policy, depending on
      patient characteristics. These data suggest that clinical practices are somewhat 
      discordant on professed beliefs about the ethical propriety of disclosure.
FAU - Rodriguez Del Pozo, Pablo
AU  - Rodriguez Del Pozo P
AD  - Division of Medical Ethics, Weill Cornell Medical College in Qatar, Doha, Qatar. 
      prd2002@qatar-med.cornell.edu
FAU - Fins, Joseph J
AU  - Fins JJ
FAU - Helmy, Ismail
AU  - Helmy I
FAU - El Chaki, Rim
AU  - El Chaki R
FAU - El Shazly, Tarek
AU  - El Shazly T
FAU - Wafaradi, Deena
AU  - Wafaradi D
FAU - Mahfoud, Ziyad
AU  - Mahfoud Z
LA  - eng
GR  - UL1 RR024996/RR/NCRR NIH HHS/United States
GR  - 1UL1 RR024996/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120808
PL  - England
TA  - Oncologist
JT  - The oncologist
JID - 9607837
SB  - IM
MH  - Adult
MH  - Arabs
MH  - Attitude of Health Personnel/*ethnology
MH  - Culture
MH  - Female
MH  - Humans
MH  - Male
MH  - Morals
MH  - Neoplasms/*diagnosis
MH  - *Physician-Patient Relations
MH  - *Practice Patterns, Physicians'
MH  - Qatar
MH  - Socioeconomic Factors
MH  - Surveys and Questionnaires
MH  - *Truth Disclosure
PMC - PMC3500369
EDAT- 2012/08/10 06:00
MHDA- 2013/06/05 06:00
CRDT- 2012/08/10 06:00
PHST- 2012/08/10 06:00 [entrez]
PHST- 2012/08/10 06:00 [pubmed]
PHST- 2013/06/05 06:00 [medline]
AID - theoncologist.2012-0128 [pii]
AID - 10.1634/theoncologist.2012-0128 [doi]
PST - ppublish
SO  - Oncologist. 2012;17(11):1469-74. doi: 10.1634/theoncologist.2012-0128. Epub 2012 
      Aug 8.


PMID- 22874064
OWN - NLM
STAT- MEDLINE
DCOM- 20130301
LR  - 20181202
IS  - 1472-6491 (Electronic)
IS  - 1472-6483 (Linking)
VI  - 25
IP  - 4
DP  - 2012 Oct
TI  - Increased cleavage rate of human nuclear transfer embryos after
      5-aza-2'-deoxycytidine treatment.
PG  - 425-33
LID - 10.1016/j.rbmo.2012.06.018 [doi]
AB  - As an abundant source that involves fewer ethical considerations, human
      abnormally fertilized zygotes are superior to oocytes as therapeutic cloning
      recipients of nuclear transfer. However, more effective manipulation conditions
      should be developed for somatic cell nuclear transfer (SCNT) studies using human 
      abnormally fertilized zygotes as recipients. The present study found that the use
      of cytochalasin B was not necessary for, and even harmful to, the enucleation of 
      human zygotes. This study also decreased the DNA methylation levels in
      reconstructed embryos using a DNA methyltransferase inhibitor,
      5-aza-2'-deoxycytidine (5-aza-dC), in an attempt to correct the abnormalities in 
      DNA methylation that might play an important role in the failure of embryo
      development. After 5-aza-dC treatment and nuclear transfer (NT-Aza group), 32.7% 
      of reconstructed embryos developed to the 8-cell stage, which is a much higher
      percentage than that of the nuclear transfer only (NT) group (11.1%). The DNA
      methylation level in the NT-Aza group was significantly lower than that of the NT
      group, as determined by 5-methylcytosine immunodetection. Based on the present
      results, this study recommends performing the enucleation procedure without
      cytochalasin B treatment and using 5-aza-dC in the culture of reconstructed
      embryos in human SCNT studies.
CI  - Copyright (c) 2012 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All
      rights reserved.
FAU - Sun, Lei
AU  - Sun L
AD  - Department of Histology and Embryology, the Second Military Medical University,
      800 Xiangyin Road, Yangpu district, Shanghai 200433, China.
FAU - Wu, Ke-Liang
AU  - Wu KL
FAU - Zhang, Di
AU  - Zhang D
FAU - Wang, Hong-Yan
AU  - Wang HY
FAU - Wang, Yue
AU  - Wang Y
FAU - Xu, Zhen-Yu
AU  - Xu ZY
FAU - Huang, Xiu-Ying
AU  - Huang XY
FAU - Chen, Zi-Jiang
AU  - Chen ZJ
FAU - Liu, Hou-Qi
AU  - Liu HQ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120708
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
RN  - 0 (Enzyme Inhibitors)
RN  - 6R795CQT4H (5-Methylcytosine)
RN  - 776B62CQ27 (Decitabine)
RN  - EC 2.1.1.- (DNA Modification Methylases)
RN  - M801H13NRU (Azacitidine)
SB  - IM
MH  - 5-Methylcytosine/metabolism
MH  - Adult
MH  - Azacitidine/*analogs & derivatives/pharmacology
MH  - China
MH  - DNA Methylation/drug effects
MH  - DNA Modification Methylases/*antagonists & inhibitors
MH  - Decitabine
MH  - Ectogenesis/*drug effects
MH  - Enzyme Inhibitors/*pharmacology
MH  - Female
MH  - Fertilization in Vitro
MH  - Humans
MH  - Infertility/metabolism/pathology/therapy
MH  - Kinetics
MH  - Male
MH  - Microscopy, Confocal
MH  - Microscopy, Fluorescence
MH  - Mitosis/drug effects
MH  - *Nuclear Transfer Techniques
MH  - Sperm Injections, Intracytoplasmic
MH  - Zygote/*drug effects/metabolism/pathology
EDAT- 2012/08/10 06:00
MHDA- 2013/03/02 06:00
CRDT- 2012/08/10 06:00
PHST- 2012/03/22 00:00 [received]
PHST- 2012/06/24 00:00 [revised]
PHST- 2012/06/25 00:00 [accepted]
PHST- 2012/08/10 06:00 [entrez]
PHST- 2012/08/10 06:00 [pubmed]
PHST- 2013/03/02 06:00 [medline]
AID - S1472-6483(12)00410-5 [pii]
AID - 10.1016/j.rbmo.2012.06.018 [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2012 Oct;25(4):425-33. doi: 10.1016/j.rbmo.2012.06.018.
      Epub 2012 Jul 8.


PMID- 22873761
OWN - NLM
STAT- MEDLINE
DCOM- 20121217
LR  - 20211021
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 13
DP  - 2012 Aug 8
TI  - Ethical aspects in tissue research: thematic analysis of ethical statements to
      the research ethics committee.
PG  - 20
LID - 10.1186/1472-6939-13-20 [doi]
AB  - BACKGROUND: Many studies have been published about ethics committees and the
      clarifications requested about the submitted applications. In Finland, ethics
      committees require a separate statement on ethical aspects of the research in
      applications to the ethics committee. However, little is known about how
      researchers consider the ethical aspects of their own studies. METHODS: The data 
      were collected from all the applications received by the official regional ethics
      committee in the Hospital District of Northern Savo during 2004-2009 (n = 688).
      These included a total of 56 studies involving research on tissue other than
      blood. The statements by the researchers about the ethics about their own
      research in these applications were analyzed by thematic content analysis under
      the following themes: recruitment, informed consent, risks and benefits,
      confidentiality and societal meaning. RESULTS: The researchers tended to describe
      recruitment and informed consent process very briefly. Usually these descriptions
      simply stated who the recruiter was and that written consent would be required.
      There was little information provided on the recruitment situation and on how the
      study recruiters would be informed. Although most of the studies were clinical,
      the possibility was hardly ever discussed that patients could fail to distinguish
      between care and research. CONCLUSION: The written guidelines, available on the
      webpages of the ethics committee, do not seem to be enough to help researchers
      achieve this goal. In addition to detailed guidelines for researchers,
      investigators need to be taught to appreciate the ethical aspects in their own
      studies.
FAU - Halkoaho, Arja
AU  - Halkoaho A
AD  - Faculty of Health Sciences, University of Eastern Finland, Research Unit/Research
      Ethics Committee, University Hospital of Kuopio, PO Box 1777, 70210 , Kuopio,
      Finland. arja.halkoaho@kuh.fi
FAU - Pietila, Anna-Maija
AU  - Pietila AM
FAU - Vesalainen, Mari
AU  - Vesalainen M
FAU - Vahakangas, Kirsi
AU  - Vahakangas K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120808
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Clinical Trials as Topic/ethics
MH  - Confidentiality/*ethics
MH  - *Ethics Committees, Research
MH  - Ethics, Research
MH  - Finland
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Patient Selection/ethics
MH  - *Research Design
PMC - PMC3472195
EDAT- 2012/08/10 06:00
MHDA- 2012/12/18 06:00
CRDT- 2012/08/10 06:00
PHST- 2011/09/13 00:00 [received]
PHST- 2012/07/30 00:00 [accepted]
PHST- 2012/08/10 06:00 [entrez]
PHST- 2012/08/10 06:00 [pubmed]
PHST- 2012/12/18 06:00 [medline]
AID - 1472-6939-13-20 [pii]
AID - 10.1186/1472-6939-13-20 [doi]
PST - epublish
SO  - BMC Med Ethics. 2012 Aug 8;13:20. doi: 10.1186/1472-6939-13-20.


PMID- 22873528
OWN - NLM
STAT- MEDLINE
DCOM- 20120827
LR  - 20211021
IS  - 1533-4406 (Electronic)
IS  - 0028-4793 (Linking)
VI  - 367
IP  - 6
DP  - 2012 Aug 9
TI  - The ethics of early evidence--preparing for a possible breakthrough in
      Alzheimer's disease.
PG  - 488-90
LID - 10.1056/NEJMp1203104 [doi]
FAU - Lowenthal, Justin
AU  - Lowenthal J
AD  - Department of Bioethics, Clinical Center, National Institutes of Health,
      Bethesda, MD, USA.
FAU - Hull, Sara Chandros
AU  - Hull SC
FAU - Pearson, Steven D
AU  - Pearson SD
LA  - eng
GR  - Z99 HG999999/Intramural NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - N Engl J Med
JT  - The New England journal of medicine
JID - 0255562
RN  - 0 (Anticarcinogenic Agents)
RN  - 0 (Tetrahydronaphthalenes)
RN  - A61RXM4375 (Bexarotene)
SB  - IM
MH  - Alzheimer Disease/*drug therapy
MH  - Animals
MH  - Anticarcinogenic Agents/therapeutic use
MH  - Bexarotene
MH  - Clinical Trials as Topic/ethics
MH  - Disease Models, Animal
MH  - *Drug Approval
MH  - *Ethics, Medical
MH  - Humans
MH  - Mice
MH  - Off-Label Use/*ethics
MH  - Tetrahydronaphthalenes/adverse effects/*therapeutic use
MH  - United States
MH  - United States Food and Drug Administration
PMC - PMC3469579
MID - NIHMS407166
EDAT- 2012/08/10 06:00
MHDA- 2012/08/28 06:00
CRDT- 2012/08/10 06:00
PHST- 2012/08/10 06:00 [entrez]
PHST- 2012/08/10 06:00 [pubmed]
PHST- 2012/08/28 06:00 [medline]
AID - 10.1056/NEJMp1203104 [doi]
PST - ppublish
SO  - N Engl J Med. 2012 Aug 9;367(6):488-90. doi: 10.1056/NEJMp1203104.


PMID- 22873034
OWN - NLM
STAT- MEDLINE
DCOM- 20120830
LR  - 20191112
IS  - 0065-3411 (Print)
IS  - 0065-3411 (Linking)
VI  - 46
DP  - 2012
TI  - What is the prognosis after retransplantation of the liver?
PG  - 87-100
AB  - In patients with failing liver grafts, hepatic retransplantation cannot be
      abandoned for the ethical and practical reasons that have been detailed
      previously. The current recommendations involve a strategy for risk
      stratification of retransplant candidates. The long-term patient and graft
      survival outcomes after ReLT are excellent and acceptable for the low and
      intermediate groups, respectively. However, pursuing ReLT in transplant
      candidates in the high-risk category cannot be recommended. Furthermore, ReLT
      should be reserved for centers equipped to manage the difficulties of the
      endeavor because it is a technically demanding operation that requires surgical
      expertise and excellent anesthesiology and critical care support both before and 
      after transplantation.
FAU - Zarrinpar, Ali
AU  - Zarrinpar A
AD  - Division of Liver and Pancreas Transplantation, Department of Surgery, David
      Geffen School of Medicine at University of California, Los Angeles, 650 C. E.
      Young Drive South, 77-120 CHS, Box 957054, Los Angeles, CA 90095, USA.
FAU - Hong, Johnny C
AU  - Hong JC
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Adv Surg
JT  - Advances in surgery
JID - 0045335
SB  - IM
MH  - Graft Rejection/surgery
MH  - Hepatectomy
MH  - Humans
MH  - Liver Failure/etiology/*surgery
MH  - *Liver Transplantation/mortality
MH  - Patient Selection
MH  - Prognosis
MH  - Reoperation
MH  - Treatment Failure
MH  - Waiting Lists
EDAT- 2012/08/10 06:00
MHDA- 2012/08/31 06:00
CRDT- 2012/08/10 06:00
PHST- 2012/08/10 06:00 [entrez]
PHST- 2012/08/10 06:00 [pubmed]
PHST- 2012/08/31 06:00 [medline]
AID - S0065-3411(12)00006-1 [pii]
AID - 10.1016/j.yasu.2012.03.005 [doi]
PST - ppublish
SO  - Adv Surg. 2012;46:87-100. doi: 10.1016/j.yasu.2012.03.005.


PMID- 22872972
OWN - NLM
STAT- MEDLINE
DCOM- 20120831
LR  - 20121203
IS  - 0025-7028 (Print)
IS  - 0025-7028 (Linking)
VI  - 101
IP  - 2
DP  - 2012
TI  - Does religion affect medical students' attitudes toward ethical dilemmas?
PG  - 22-3
FAU - Elliott, Richard L
AU  - Elliott RL
AD  - elliott_rl@mercer.edu
FAU - Chowdhury, Morium
AU  - Chowdhury M
FAU - Wilson, Laurie
AU  - Wilson L
FAU - Dane, Francis C
AU  - Dane FC
FAU - Williams, Stephen
AU  - Williams S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Med Assoc Ga
JT  - Journal of the Medical Association of Georgia
JID - 7505620
SB  - IM
CIN - J Med Assoc Ga. 2012;101(3):5; discussion 5. PMID: 23198618
MH  - Abortion, Induced/ethics
MH  - *Attitude of Health Personnel
MH  - *Ethics, Medical
MH  - Female
MH  - Fertilization in Vitro/ethics
MH  - Humans
MH  - Male
MH  - *Religion and Medicine
MH  - Students, Medical/*psychology
EDAT- 2012/08/10 06:00
MHDA- 2012/09/01 06:00
CRDT- 2012/08/10 06:00
PHST- 2012/08/10 06:00 [entrez]
PHST- 2012/08/10 06:00 [pubmed]
PHST- 2012/09/01 06:00 [medline]
PST - ppublish
SO  - J Med Assoc Ga. 2012;101(2):22-3.


PMID- 22872552
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20191210
IS  - 1098-8793 (Electronic)
IS  - 0736-6825 (Linking)
VI  - 28
IP  - 4
DP  - 2012 Aug
TI  - Ethical considerations in revision rhinoplasty.
PG  - 369-73
LID - 10.1055/s-0032-1319834 [doi]
AB  - The problems that arise when reviewing another surgeon's work, the financial
      aspects of revision surgery, and the controversies that present in marketing and 
      advertising will be explored. The technological advances of computer imaging and 
      the Internet have introduced new problems that require our additional
      consideration.
CI  - Copyright (c) 2012 by Thieme Medical Publishers, Inc.
FAU - Wayne, Ivan
AU  - Wayne I
AD  - Department of Otorhinolaryngology, University of Oklahoma, Oklahoma City, 73104, 
      USA. ivan-wayne@ouhsc.edu
LA  - eng
PT  - Journal Article
DEP - 20120807
PL  - United States
TA  - Facial Plast Surg
JT  - Facial plastic surgery : FPS
JID - 8405303
MH  - Advertising/ethics
MH  - Blogging
MH  - Dissent and Disputes
MH  - Electronic Mail
MH  - *Ethics, Medical
MH  - Fees, Medical
MH  - Financing, Personal
MH  - Health Care Costs
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Informed Consent/ethics
MH  - Internet
MH  - Interprofessional Relations/ethics
MH  - Marketing of Health Services/ethics
MH  - Medical Errors/ethics
MH  - Patient Care Planning
MH  - Photography
MH  - Physician-Patient Relations/ethics
MH  - Reoperation/ethics
MH  - Rhinoplasty/economics/*ethics
MH  - Social Media
MH  - Standard of Care
EDAT- 2012/08/09 06:00
MHDA- 2013/03/13 06:00
CRDT- 2012/08/09 06:00
PHST- 2012/08/09 06:00 [entrez]
PHST- 2012/08/09 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
AID - 10.1055/s-0032-1319834 [doi]
PST - ppublish
SO  - Facial Plast Surg. 2012 Aug;28(4):369-73. doi: 10.1055/s-0032-1319834. Epub 2012 
      Aug 7.


PMID- 22872503
OWN - NLM
STAT- MEDLINE
DCOM- 20130104
LR  - 20220311
IS  - 1573-7284 (Electronic)
IS  - 0393-2990 (Linking)
VI  - 27
IP  - 9
DP  - 2012 Sep
TI  - Generalizability of results from the National Lung Screening Trial.
PG  - 669-72
LID - 10.1007/s10654-012-9720-8 [doi]
AB  - Lung cancer is the major cause of cancer-related death worldwide, with a 5-year
      survival of only 16%. Most lung cancer cases are diagnosed at an advanced
      incurable stage. As earlier stages have a better prognosis, the key to reducing
      mortality could be early diagnosis of the disease. At present, low-dose computed 
      tomographic (CT) screening has shown promising data. Lung cancer death rates were
      reduced by 20% when CT screening is compared to chest radiography in a high-risk 
      group. There are many advantages of CT screening in lung cancer, however there
      are also some important issues that should be taken into account. Therefore, the 
      applicability of the results to clinical practice is not clear yet. In this
      Commentary we discuss different aspects that play important roles in the balance 
      between harms and benefits of screening, including overdiagnosis, availability of
      treatment options worldwide, ethical considerations, costs, and prolonged life
      expectancy. We conclude that clinicians should be cautious in generalizing
      findings to the total population of smokers and take into account that the use of
      lung cancer screening in clinical practice may have limitations.
FAU - Heuvers, Marlies E
AU  - Heuvers ME
AD  - Department of Respiratory Diseases and Tuberculosis, Erasmus Medical University
      Center, Rotterdam, The Netherlands, m.heuvers@erasmusmc.nl
FAU - Wisnivesky, Juan
AU  - Wisnivesky J
FAU - Stricker, Bruno H
AU  - Stricker BH
FAU - Aerts, Joachim G
AU  - Aerts JG
LA  - eng
PT  - Journal Article
DEP - 20120808
PL  - Netherlands
TA  - Eur J Epidemiol
JT  - European journal of epidemiology
JID - 8508062
SB  - IM
MH  - Aged
MH  - Bias
MH  - *Early Detection of Cancer/economics
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/*diagnostic imaging/economics/epidemiology/*prevention & control
MH  - Male
MH  - Mass Screening/economics/methods/statistics & numerical data
MH  - Middle Aged
MH  - Smoking/adverse effects
MH  - *Tomography, X-Ray Computed/economics/methods
EDAT- 2012/08/09 06:00
MHDA- 2013/01/05 06:00
CRDT- 2012/08/09 06:00
PHST- 2012/03/28 00:00 [received]
PHST- 2012/07/12 00:00 [accepted]
PHST- 2012/08/09 06:00 [entrez]
PHST- 2012/08/09 06:00 [pubmed]
PHST- 2013/01/05 06:00 [medline]
AID - 10.1007/s10654-012-9720-8 [doi]
PST - ppublish
SO  - Eur J Epidemiol. 2012 Sep;27(9):669-72. doi: 10.1007/s10654-012-9720-8. Epub 2012
      Aug 8.


PMID- 22872349
OWN - NLM
STAT- MEDLINE
DCOM- 20121231
LR  - 20190907
IS  - 1678-4561 (Electronic)
IS  - 1413-8123 (Linking)
VI  - 17
IP  - 7
DP  - 2012 Jul
TI  - [Therapeutic techniques and subjectivation in treatment with drug users].
PG  - 1865-74
LID - S1413-81232012000700026 [pii]
AB  - The internment process in therapeutic communities (TC) involves a multiplicity of
      therapeutic practices and strategies geared to abstinence from drug usage.
      According to the specialists' own regulations and explicit objectives, the
      residents must not only abandon the consumption of substances but also adopt new 
      practices, attitudes, emotions and significances through the use of therapeutic
      techniques that allow them to adapt to the structure of the organization that
      these institutions impose. Based on the results of the ethnographic survey
      carried out between 2009 and 2010 in three TCs of the metropolitan area of Buenos
      Aires, Argentina, the scope of this article is to analyze from a sociological and
      anthropological standpoint the "therapeutic tools" that comprise the treatment,
      the subject models that underlie these tools, the consequences that they may
      produce and their participation in the subjectivity production processes. For
      this purpose, we focus on analysis of "confrontation" as a privileged and
      omnipresent strategy of subjectivation in these therapeutic contexts, in order to
      reveal the epistemological, economic, political and ethical dimensions in the
      de-subjectivation process of the institutionalized drug user.
FAU - Garbi, Silvana Laura
AU  - Garbi SL
AD  - Instituto de Investigaciones Gino Germani, Facultad de Ciencias Sociales,
      Universidad de Buenos Aires, Buenos Aires, Argentina. garbisilvana@hotmail.com
FAU - Touris, Maria Cecilia
AU  - Touris MC
FAU - Epele, Maria
AU  - Epele M
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Tecnicas terapeuticas y subjetivacion en tratamientos con usuarios/as de drogas.
PL  - Brazil
TA  - Cien Saude Colet
JT  - Ciencia & saude coletiva
JID - 9713483
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - Humans
MH  - Male
MH  - Substance-Related Disorders/psychology/*therapy
MH  - Young Adult
EDAT- 2012/08/09 06:00
MHDA- 2013/01/01 06:00
CRDT- 2012/08/09 06:00
PHST- 2011/04/13 00:00 [received]
PHST- 2011/06/07 00:00 [accepted]
PHST- 2012/08/09 06:00 [entrez]
PHST- 2012/08/09 06:00 [pubmed]
PHST- 2013/01/01 06:00 [medline]
AID - S1413-81232012000700026 [pii]
AID - 10.1590/s1413-81232012000700026 [doi]
PST - ppublish
SO  - Cien Saude Colet. 2012 Jul;17(7):1865-74. doi: 10.1590/s1413-81232012000700026.


PMID- 22872341
OWN - NLM
STAT- MEDLINE
DCOM- 20121231
LR  - 20190907
IS  - 1678-4561 (Electronic)
IS  - 1413-8123 (Linking)
VI  - 17
IP  - 7
DP  - 2012 Jul
TI  - [Cytotec and abortion: the police, the vendors and women].
PG  - 1795-804
LID - S1413-81232012000700018 [pii]
AB  - This paper analyzes the illegal trade in misoprostol, the medication
      predominantly used for abortion in Brazil. The study analyzed ten cases that came
      to the attention of the Public Prosecution Service for the Federal District
      between 2004 and 2010. The cases were organized into three categories: 1. women's
      stories; 2. profile of the vendors; 3. maternal mortality cases. The research was
      reviewed by an ethics committee. The main outcomes were: 1. young women in steady
      relationships use misoprostol in the home or with the assistance of drug vendors.
      Of the seven women indicted, three were reported on arrival at the public
      hospital to finalize abortion; 2. the drug vendors work at the community
      drugstore and are local agents for the sale of misoprostol. They instruct women
      on how to use the drug and how to prevent infections, but refuse to provide them 
      with care in case of emergency. Traffickers operate via the internet and have a
      larger inventory of drugs; 3. there were two cases of maternal mortality due to
      the combination of high risk methods, such as a vaginal probe and misoprostol.
      The main causes for maternal mortality are the delay in seeking medical care, as 
      the women fear criminal prosecution, and the combined use of misoprostol with
      high risk methods.
FAU - Diniz, Debora
AU  - Diniz D
AD  - Programa de Pos-Graduacao em Politica Social, Universidade de Brasilia, Brasilia,
      DF. d.diniz@gmx.com
FAU - Madeiro, Alberto
AU  - Madeiro A
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Cytotec e aborto: a policia, os vendedores e as mulheres.
PL  - Brazil
TA  - Cien Saude Colet
JT  - Ciencia & saude coletiva
JID - 9713483
RN  - 0 (Abortifacient Agents, Nonsteroidal)
RN  - 0E43V0BB57 (Misoprostol)
SB  - IM
MH  - *Abortifacient Agents, Nonsteroidal
MH  - *Abortion, Criminal
MH  - *Abortion, Induced
MH  - Adult
MH  - Brazil
MH  - *Commerce
MH  - Female
MH  - Humans
MH  - *Misoprostol
MH  - *Police
MH  - Pregnancy
MH  - Young Adult
EDAT- 2012/08/09 06:00
MHDA- 2013/01/01 06:00
CRDT- 2012/08/09 06:00
PHST- 2011/03/15 00:00 [received]
PHST- 2011/07/17 00:00 [accepted]
PHST- 2012/08/09 06:00 [entrez]
PHST- 2012/08/09 06:00 [pubmed]
PHST- 2013/01/01 06:00 [medline]
AID - S1413-81232012000700018 [pii]
AID - 10.1590/s1413-81232012000700018 [doi]
PST - ppublish
SO  - Cien Saude Colet. 2012 Jul;17(7):1795-804. doi: 10.1590/s1413-81232012000700018.


PMID- 22872337
OWN - NLM
STAT- MEDLINE
DCOM- 20121231
LR  - 20190907
IS  - 1678-4561 (Electronic)
IS  - 1413-8123 (Linking)
VI  - 17
IP  - 7
DP  - 2012 Jul
TI  - [Practice in situations of legal abortion from the perspective of health
      professionals at Fernando Magalhaes public hospital].
PG  - 1755-63
LID - S1413-81232012000700014 [pii]
AB  - The scope of this study was to analyze perceptions of health professionals at
      Fernando Magalhaes Public Hospital regarding situations involving the practice of
      legal abortion. With this in mind, we sought to characterize the professionals
      interviewed, understand the qualifying process for assistance of women requiring 
      abortion and identify the perceptions of the professionals regarding the practice
      of legal abortion. The quantitative and qualitative approach in terms of
      methodology was adopted. The instruments used were analysis of institutional
      documentation and semi-structured interviews based on a script with informed
      consent. The results of this research revealed: the inappropriate use of the
      right to conscientious objection by health professionals; the existence of
      difficulties faced by professionals in construction of a posture that ensures
      access to legally sanctioned abortion; and the interference of ethical and
      religious values as an important element in professional attitudes that
      discourage the practice of legal abortion. Measures for the ongoing education of 
      professionals and the monitoring of actions applied to technical norms are
      recommended.
FAU - Farias, Rejane Santos
AU  - Farias RS
AD  - Nucleo de Politicas Publicas, Indicadores e Identidades, Escola de Servico
      Social, Universidade Federal do Rio de Janeiro. rejanes_farias@yahoo.com.br
FAU - Cavalcanti, Ludmila Fontenele
AU  - Cavalcanti LF
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Atuacao diante das situacoes de aborto legal na perspectiva dos profissionais de 
      saude do Hospital Municipal Fernando Magalhaes.
PL  - Brazil
TA  - Cien Saude Colet
JT  - Ciencia & saude coletiva
JID - 9713483
SB  - IM
MH  - *Abortion, Legal
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Brazil
MH  - Female
MH  - Hospitals, Public
MH  - Humans
MH  - Middle Aged
MH  - Pregnancy
EDAT- 2012/08/09 06:00
MHDA- 2013/01/01 06:00
CRDT- 2012/08/09 06:00
PHST- 2011/11/30 00:00 [received]
PHST- 2012/02/16 00:00 [accepted]
PHST- 2012/08/09 06:00 [entrez]
PHST- 2012/08/09 06:00 [pubmed]
PHST- 2013/01/01 06:00 [medline]
AID - S1413-81232012000700014 [pii]
AID - 10.1590/s1413-81232012000700014 [doi]
PST - ppublish
SO  - Cien Saude Colet. 2012 Jul;17(7):1755-63. doi: 10.1590/s1413-81232012000700014.


PMID- 22872032
OWN - NLM
STAT- MEDLINE
DCOM- 20121102
LR  - 20211021
IS  - 1940-087X (Electronic)
IS  - 1940-087X (Linking)
IP  - 65
DP  - 2012 Jul 30
TI  - Non-invasive imaging of disseminated candidiasis in zebrafish larvae.
LID - 10.3791/4051 [doi]
LID - 4051 [pii]
AB  - Disseminated candidiasis caused by the pathogen Candida albicans is a clinically 
      important problem in hospitalized individuals and is associated with a 30 to 40% 
      attributable mortality(6). Systemic candidiasis is normally controlled by innate 
      immunity, and individuals with genetic defects in innate immune cell components
      such as phagocyte NADPH oxidase are more susceptible to candidemia(7-9). Very
      little is known about the dynamics of C. albicans interaction with innate immune 
      cells in vivo. Extensive in vitro studies have established that outside of the
      host C. albicans germinates inside of macrophages, and is quickly destroyed by
      neutrophils(10-14). In vitro studies, though useful, cannot recapitulate the
      complex in vivo environment, which includes time-dependent dynamics of cytokine
      levels, extracellular matrix attachments, and intercellular contacts(10, 15-18). 
      To probe the contribution of these factors in host-pathogen interaction, it is
      critical to find a model organism to visualize these aspects of infection
      non-invasively in a live intact host. The zebrafish larva offers a unique and
      versatile vertebrate host for the study of infection. For the first 30 days of
      development zebrafish larvae have only innate immune defenses(2, 19-21),
      simplifying the study of diseases such as disseminated candidiasis that are
      highly dependent on innate immunity. The small size and transparency of zebrafish
      larvae enable imaging of infection dynamics at the cellular level for both host
      and pathogen. Transgenic larvae with fluorescing innate immune cells can be used 
      to identify specific cells types involved in infection(22-24). Modified
      anti-sense oligonucleotides (Morpholinos) can be used to knock down various
      immune components such as phagocyte NADPH oxidase and study the changes in
      response to fungal infection(5). In addition to the ethical and practical
      advantages of using a small lower vertebrate, the zebrafish larvae offers the
      unique possibility to image the pitched battle between pathogen and host both
      intravitally and in color. The zebrafish has been used to model infection for a
      number of human pathogenic bacteria, and has been instrumental in major advances 
      in our understanding of mycobacterial infection(3, 25). However, only recently
      have much larger pathogens such as fungi been used to infect larva(5, 23, 26),
      and to date there has not been a detailed visual description of the infection
      methodology. Here we present our techniques for hindbrain ventricle
      microinjection of prim(25) zebrafish, including our modifications to previous
      protocols. Our findings using the larval zebrafish model for fungal infection
      diverge from in vitro studies and reinforce the need to examine the host-pathogen
      interaction in the complex environment of the host rather than the simplified
      system of the Petri dish(5).
FAU - Brothers, Kimberly M
AU  - Brothers KM
AD  - Department of Molecular and Biomedical Sciences, University of Maine.
FAU - Wheeler, Robert T
AU  - Wheeler RT
LA  - eng
GR  - P20 RR016463/RR/NCRR NIH HHS/United States
GR  - R15 AI094406/AI/NIAID NIH HHS/United States
GR  - P20RR016463/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Video-Audio Media
DEP - 20120730
PL  - United States
TA  - J Vis Exp
JT  - Journal of visualized experiments : JoVE
JID - 101313252
SB  - IM
MH  - Animals
MH  - Animals, Genetically Modified
MH  - Candida albicans/*chemistry
MH  - Candidiasis/*immunology/*microbiology
MH  - *Disease Models, Animal
MH  - Host-Pathogen Interactions/immunology
MH  - Immunity, Innate
MH  - Injections
MH  - Larva
MH  - Macrophages/immunology/microbiology
MH  - Microscopy, Confocal/*methods
MH  - Rhombencephalon/microbiology
MH  - Zebrafish
PMC - PMC3468152
MID - NIHMS411141
EDAT- 2012/08/09 06:00
MHDA- 2012/11/03 06:00
CRDT- 2012/08/09 06:00
PHST- 2012/08/09 06:00 [entrez]
PHST- 2012/08/09 06:00 [pubmed]
PHST- 2012/11/03 06:00 [medline]
AID - 4051 [pii]
AID - 10.3791/4051 [doi]
PST - epublish
SO  - J Vis Exp. 2012 Jul 30;(65). pii: 4051. doi: 10.3791/4051.


PMID- 22871230
OWN - NLM
STAT- MEDLINE
DCOM- 20121221
LR  - 20211021
IS  - 1471-2431 (Electronic)
IS  - 1471-2431 (Linking)
VI  - 12
DP  - 2012 Aug 7
TI  - Pilot study of a model-based approach to blood glucose control in
      very-low-birthweight neonates.
PG  - 117
LID - 10.1186/1471-2431-12-117 [doi]
AB  - BACKGROUND: Hyperglycemia often occurs in premature, very low birthweight infants
      (VLBW) due to immaturity of endogenous regulatory systems and the stress of their
      condition. Hyperglycemia in neonates has been linked to increased morbidities and
      mortality and occurs at increasing rates with decreasing birthweight. In this
      cohort, the emerging use of insulin to manage hyperglycemia has carried a
      significant risk of hypoglycemia. The efficacy of blood glucose control using a
      computer metabolic system model to determine insulin infusion rates was assessed 
      in very-low-birth-weight infants. METHODS: Initial short-term 24-hour trials were
      performed on 8 VLBW infants with hyperglycemia followed by long-term trials of
      several days performed on 22 infants. Median birthweight was 745 g and 760 g for 
      short-term and long-term trial infants, and median gestational age at birth was
      25.6 and 25.4 weeks respectively. Blood glucose control is compared to 21
      retrospective patients from the same unit who received insulin infusions
      determined by sliding scales and clinician intuition. This study was approved by 
      the Upper South A Regional Ethics Committee, New Zealand (ClinicalTrials.gov
      registration NCT01419873). RESULTS: Reduction in hyperglycemia towards the target
      glucose band was achieved safely in all cases during the short-term trials with
      no hypoglycemic episodes. Lower median blood glucose concentration was achieved
      during clinical implementation at 6.6 mmol/L (IQR: 5.5 - 8.2 mmol/L, 1,003
      measurements), compared to 8.0 mmol/L achieved in similar infants previously (p <
      0.01). No significant difference in incidence of hypoglycemia during long-term
      trials was observed (0.25% vs 0.25%, p = 0.51). Percentage of blood glucose
      within the 4.0 - 8.0 mmol/L range was increased by 41% compared to the
      retrospective cohort (68.4% vs 48.4%, p < 0.01). CONCLUSIONS: A computer model
      that accurately captures the dynamics of neonatal metabolism can provide safe and
      effective blood glucose control without increasing hypoglycemia. TRIAL
      REGISTRATION: ClinicalTrials.gov registration NCT01419873.
FAU - Le Compte, Aaron J
AU  - Le Compte AJ
AD  - Department of Mechanical Engineering, University of Canterbury, Christchurch, New
      Zealand. aaron.lecompte@canterbury.ac.nz
FAU - Lynn, Adrienne M
AU  - Lynn AM
FAU - Lin, Jessica
AU  - Lin J
FAU - Pretty, Christopher G
AU  - Pretty CG
FAU - Shaw, Geoffrey M
AU  - Shaw GM
FAU - Chase, J Geoffrey
AU  - Chase JG
LA  - eng
SI  - ClinicalTrials.gov/NCT01419873
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120807
PL  - England
TA  - BMC Pediatr
JT  - BMC pediatrics
JID - 100967804
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
SB  - IM
MH  - Algorithms
MH  - Biomarkers/blood
MH  - Blood Glucose/*metabolism
MH  - Humans
MH  - Hyperglycemia/blood/*drug therapy
MH  - Hypoglycemia/blood/chemically induced/prevention & control
MH  - Hypoglycemic Agents/*administration & dosage/therapeutic use
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Infant, Premature, Diseases/blood/*drug therapy
MH  - Infant, Very Low Birth Weight/*blood
MH  - Insulin/*administration & dosage/therapeutic use
MH  - Insulin Infusion Systems
MH  - Insulin Resistance
MH  - *Models, Biological
MH  - Pilot Projects
PMC - PMC3465220
EDAT- 2012/08/09 06:00
MHDA- 2012/12/22 06:00
CRDT- 2012/08/09 06:00
PHST- 2012/02/21 00:00 [received]
PHST- 2012/07/26 00:00 [accepted]
PHST- 2012/08/09 06:00 [entrez]
PHST- 2012/08/09 06:00 [pubmed]
PHST- 2012/12/22 06:00 [medline]
AID - 1471-2431-12-117 [pii]
AID - 10.1186/1471-2431-12-117 [doi]
PST - epublish
SO  - BMC Pediatr. 2012 Aug 7;12:117. doi: 10.1186/1471-2431-12-117.


PMID- 22870841
OWN - NLM
STAT- MEDLINE
DCOM- 20121231
LR  - 20120808
IS  - 1512-0112 (Print)
IS  - 1512-0112 (Linking)
IP  - 206
DP  - 2012 May
TI  - Medical discourse in pathological anatomy.
PG  - 63-6
AB  - The paper is devoted to the peculiarities of medical discourse in pathological
      anatomy as coherent speech and as a linguistic correlate of medical practice
      taking into account the analysis of its strategies and tactics. The purpose of
      the paper is to provide a multifaceted analysis of the speech strategies and
      tactics of pathological anatomy discourse and ways of their implementation. The
      main strategies of medical discourse in pathological anatomy are an anticipating 
      strategy, a diagnosing strategy and an explaining one. The supporting strategies 
      are pragmatic, conversational and a rhetorical one. The pragmatic strategy is
      implemented through contact establishing tactics, the conversational one - with
      the help of control tactics, the rhetorical one - with the help of attention
      correction tactics. The above mentioned tactics and strategies are used in the
      distinguishing of major, closely interrelated strategies: "the contact strategy" 
      (to establish contact with a patient's relatives - phatic replicas of greeting
      and addressing) and "the strategy of explanation" (used in the practice of a
      pathologist for a detailed explanation of the reasons of a patient's death). The 
      ethic aspect of speech conduct of a doctor-pathologist is analyzed.
FAU - Moskalenko, R
AU  - Moskalenko R
AD  - Department of pathomorphology, Sumy State University, Sumy, Ukraine.
FAU - Tatsenko, N
AU  - Tatsenko N
FAU - Romanyuk, A
AU  - Romanyuk A
FAU - Perelomova, O
AU  - Perelomova O
FAU - Moskalenko, Yu
AU  - Moskalenko Y
LA  - eng
PT  - Journal Article
PL  - Georgia (Republic)
TA  - Georgian Med News
JT  - Georgian medical news
JID - 101218222
SB  - IM
MH  - *Education, Medical
MH  - Humans
MH  - Linguistics/education/trends
MH  - *Pathology/education/standards
EDAT- 2012/08/09 06:00
MHDA- 2013/01/01 06:00
CRDT- 2012/08/09 06:00
PHST- 2012/08/09 06:00 [entrez]
PHST- 2012/08/09 06:00 [pubmed]
PHST- 2013/01/01 06:00 [medline]
PST - ppublish
SO  - Georgian Med News. 2012 May;(206):63-6.


PMID- 22870754
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20191112
IS  - 0001-5385 (Print)
IS  - 0001-5385 (Linking)
VI  - 67
IP  - 3
DP  - 2012 Jun
TI  - Relations between professional medical associations and the health-care industry,
      concerning scientific communication and continuing medical education: a policy
      statement from the European Society of Cardiology.
PG  - 379-90
AB  - Physicians have an ethical duty to keep up-to-date with current knowledge.
      Professional medical associations such as the European Society of Cardiology
      (ESC) support these obligations. In Europe, the costs of continuing medical
      education (CME) are insufficiently supported from governments and employers;
      however, medical associations have been criticized for accepting alternative
      financial support from industry. Medical education and training in research
      include learning how to assess the quality and reliability of any information.
      There is some risk of bias in any form of scientific communication including
      intellectual, professional, and financial and it is essential that in particular,
      the latter must be acknowledged by full disclosure. It is essential that there is
      strong collaboration between basic and clinical researchers from academic
      institutions on the one hand, with engineers and scientists from the research
      divisions of device and pharmaceutical companies on the other. This is vital so
      that new diagnostic methods and treatments are developed. Promotion of advances
      by industry may accelerate their implementation into clinical practice.
      Universities now frequently exhort their academic staff to protect their
      intellectual property or commercialize their research. Thus, it is not commercial
      activity or links per se that have become the target for criticism but the
      perceived influence of commercial enterprises on clinical decision-making or on
      messages conveyed by professional medical organizations. This document offers the
      perspective of the ESC on the current debate, and it recommends how to minimize
      bias in scientific communications and CME and how to ensure proper ethical
      standards and transparency in relations between the medical profession and
      industry.
CN  - ESC Board
LA  - eng
PT  - Journal Article
PL  - England
TA  - Acta Cardiol
JT  - Acta cardiologica
JID - 0370570
SB  - IM
MH  - Bias
MH  - Cardiology/economics/*education/ethics
MH  - Education, Medical, Continuing/economics/*ethics/organization & administration
MH  - Europe
MH  - Health Care Sector/economics/*ethics
MH  - Internet
MH  - Interprofessional Relations/*ethics
MH  - Organizational Policy
MH  - Periodicals as Topic
MH  - Practice Guidelines as Topic
MH  - Research Support as Topic/ethics
MH  - Societies, Medical/economics/*ethics
EDAT- 2012/08/09 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/08/09 06:00
PHST- 2012/08/09 06:00 [entrez]
PHST- 2012/08/09 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
AID - 10.1080/ac.67.3.02160736 [doi]
PST - ppublish
SO  - Acta Cardiol. 2012 Jun;67(3):379-90. doi: 10.1080/ac.67.3.02160736.


PMID- 22870411
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120905
LR  - 20211021
IS  - 2229-340X (Electronic)
IS  - 1319-1683 (Linking)
VI  - 19
IP  - 2
DP  - 2012 May
TI  - Predictors of pulmonary involvement in patients with extra-pulmonary
      tuberculosis.
PG  - 88-92
LID - 10.4103/2230-8229.98287 [doi]
AB  - OBJECTIVES: The aim of this study is to assess the value of chest radiographs
      (CXRs) and sputum examinations in detecting pulmonary involvement of tuberculosis
      (TB) in patients with extra-pulmonary tuberculosis (EPTB). MATERIALS AND METHODS:
      A retrospective analysis was performed among 248 EPTB patients with
      culture-proven diagnosis of tuberculosis seen between January 2001 and December
      2007 at a tertiary teaching hospital, Riyadh, Saudi Arabia. Demographics,
      clinical, laboratory and radiological findings were reviewed and assessed. This
      study was approved by the hospital ethics and research committee. RESULTS: One
      hundred twenty five of 233 EPTB patients (53.6%) had abnormal CXR findings. There
      was a significant difference in the occurrence of positive sputum culture results
      between patients with abnormal CXR findings (30/57) and those with normal CXR
      findings (4/17) (P = 0.04). Of 17 HIV-negative/unknown HIV-status EPTB patients
      with normal CXR results, 4 patients (23.5%) had positive sputum culture results. 
      Intrathoracic lymphadenopathy (P < 0.001), pleural TB (P < 0. 001) and
      disseminated TB (P = 0.004) were associated with an increased risk of abnormal
      CXR findings. Patients with cough (52.9%), weight loss (41.2%) and night sweats
      (26.5%) are more likely to have positive sputum culture results. CONCLUSION: CXR 
      findings are predictive of positive sputum culture results. However, the rate of 
      normal CXR among EPTB patients with positive sputum culture results was
      relatively high. Therefore, respiratory specimen cultures should be obtained in
      TB suspects with a normal CXR to identify potentially infectious cases of TB.
FAU - El-Hazmi, Malak M
AU  - El-Hazmi MM
AD  - Department of Microbiology, King Khalid University Hospital, King Saud
      University, Riyadh, Saudi Arabia.
FAU - Al-Otaibi, Fawzia E
AU  - Al-Otaibi FE
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Family Community Med
JT  - Journal of family & community medicine
JID - 100911100
PMC - PMC3410185
OTO - NOTNLM
OT  - Predictors
OT  - extra-pulmonary tuberculosis
OT  - pulmonary
OT  - radiology
EDAT- 2012/08/08 06:00
MHDA- 2012/08/08 06:01
CRDT- 2012/08/08 06:00
PHST- 2012/08/08 06:00 [entrez]
PHST- 2012/08/08 06:00 [pubmed]
PHST- 2012/08/08 06:01 [medline]
AID - 10.4103/2230-8229.98287 [doi]
AID - JFCM-19-88 [pii]
PST - ppublish
SO  - J Family Community Med. 2012 May;19(2):88-92. doi: 10.4103/2230-8229.98287.


PMID- 22870360
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2005-7563 (Electronic)
IS  - 2005-6419 (Linking)
VI  - 63
IP  - 1
DP  - 2012 Jul
TI  - In vivo effects of different anesthetic agents on apoptosis.
PG  - 18-24
LID - 10.4097/kjae.2012.63.1.18 [doi]
AB  - BACKGROUND: This study was designed to measure in vivo effects of propofol,
      isoflurane and sevoflurane on apoptosis by measuring caspase-3 and tumor necrosis
      factor (TNF)-related apoptosis inducing ligand (TRAIL) blood level as apoptotic
      markers. METHODS: After obtaining ethical committee approval and informed written
      consents, sixty adult patients ASA I scheduled for open cholecystectomy
      participated in this study. They were randomally allocated into one of three
      equal groups to receive propofol infusion, low-flow isoflurane or sevoflurane for
      maintenance of anesthesia. Venous blood samples were collected preoperatively,
      immediately postoperative and after 24 hours to measure hemoglobin, hematocrit,
      creatinine, liver enzymes, serum TRAIL and caspase-3 levels. RESULTS: There was
      no significant difference in hematological markers and serum creatinine. Liver
      enzymes showed significant postoperative rise (P < 0.05). In Propofol group,
      TRAIL and caspase-3 levels were significantly elevated immediately postoperative 
      then decreased significantly after 24-hours (P < 0.05). In Isoflurane group,
      immediate postoperative level of TRAIL was significantly higher than 24 hours
      reading and significantly lower than its level in Propofol group at the same
      timing meanwhile caspase-3 levels were comparable at different timings. In
      Sevoflurane group, TRAIL and caspase-3 levels increased significantly in both
      postoperative samples than preoperative level and than those of Isoflurane and
      Propofol groups after 24 hours concerning TRAIL (P & 0.05). CONCLUSIONS: This
      study concluded that isoflurane is superior and sevoflurane is the least
      effective among the three anesthetics in protection against apoptosis. This study
      neither proved nor excluded propofol-induced apoptosis. Further studies are
      required during lengthy procedure and in compromised patients.
FAU - Osman, Emad S
AU  - Osman ES
AD  - Department of Anesthesiology, Theodor Bilharz Research Institute, Giza, Egypt.
FAU - Khafagy, Hanan F
AU  - Khafagy HF
FAU - Samhan, Yasser M
AU  - Samhan YM
FAU - Hassan, Mona M
AU  - Hassan MM
FAU - El-Shanawany, Faten M
AU  - El-Shanawany FM
FAU - Fathallah, Abdel Rahman M
AU  - Fathallah AR
FAU - El-Fandy, Gehan G
AU  - El-Fandy GG
LA  - eng
PT  - Journal Article
DEP - 20120724
PL  - Korea (South)
TA  - Korean J Anesthesiol
JT  - Korean journal of anesthesiology
JID - 101502451
PMC - PMC3408509
OTO - NOTNLM
OT  - Apoptosis
OT  - In vivo
OT  - Isoflurane
OT  - Propofol
OT  - Sevoflurane
EDAT- 2012/08/08 06:00
MHDA- 2012/08/08 06:01
CRDT- 2012/08/08 06:00
PHST- 2011/10/20 00:00 [received]
PHST- 2012/01/13 00:00 [revised]
PHST- 2012/01/25 00:00 [accepted]
PHST- 2012/08/08 06:00 [entrez]
PHST- 2012/08/08 06:00 [pubmed]
PHST- 2012/08/08 06:01 [medline]
AID - 10.4097/kjae.2012.63.1.18 [doi]
PST - ppublish
SO  - Korean J Anesthesiol. 2012 Jul;63(1):18-24. doi: 10.4097/kjae.2012.63.1.18. Epub 
      2012 Jul 24.


PMID- 22869251
OWN - NLM
STAT- MEDLINE
DCOM- 20121226
LR  - 20210820
IS  - 1527-3172 (Electronic)
IS  - 1527-3172 (Linking)
VI  - 14
IP  - 3
DP  - 2012 Jul
TI  - The vocation to serve: cornerstone of health care.
PG  - 52
LID - 10.37757/MR2012V14.N3.11 [doi]
AB  - Twenty-five hundred years ago, Hippocrates bequeathed a set of ethical precepts
      that emphasized the social transcendence of the practice of medicine and the
      profound commitment of physicians to serve patients and their families selflessly
      and with a pure heart.[1] Traditionally, small-town medical practice facilitated 
      spontaneous interpersonal relationships between family doctors and nurses and
      their patients. Later, however, centralization of health services in large
      medical complexes, an explosion of technology not always wisely deployed,
      litigiousness, tabloid journalism and commercialism in health service provision
      have created conditions that are, to say the least, less than propitious for
      optimal satisfaction on the part of patients and families. In my view, this has
      been accompanied by a dangerous devaluation of clinical skills, of medicine as a 
      vocation, and by deterioration in the relationship of physicians and other health
      professionals with patients and their families.
FAU - Gonzalez, Ricardo A
AU  - Gonzalez RA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - MEDICC Rev
JT  - MEDICC review
JID - 100964771
SB  - IM
MH  - *Ethics, Clinical
MH  - Humans
MH  - Physician-Patient Relations/*ethics
MH  - Physicians/*ethics
EDAT- 2012/08/08 06:00
MHDA- 2012/12/27 06:00
CRDT- 2012/08/08 06:00
PHST- 2012/08/08 06:00 [entrez]
PHST- 2012/08/08 06:00 [pubmed]
PHST- 2012/12/27 06:00 [medline]
AID - 10.37757/MR2012V14.N3.11 [doi]
PST - ppublish
SO  - MEDICC Rev. 2012 Jul;14(3):52. doi: 10.37757/MR2012V14.N3.11.


PMID- 22869245
OWN - NLM
STAT- MEDLINE
DCOM- 20121226
LR  - 20210820
IS  - 1527-3172 (Electronic)
IS  - 1527-3172 (Linking)
VI  - 14
IP  - 3
DP  - 2012 Jul
TI  - Assessment of a complementary curricular strategy for training South African
      physicians in a Cuban medical university.
PG  - 19-24
LID - 10.37757/MR2012V14.N3.4 [doi]
AB  - INTRODUCTION: One reason given by the South African government for establishing a
      physician training agreement with Cuba is that the ethical, humanistic and
      solidarity principles promoted in Cuban medical education are difficult to
      acquire in other settings. However, Cuba's general medical training program does 
      not provide all skills needed by a general practitioner in South Africa: other
      competencies are required, such as management of general and gynecological or
      obstetrical surgical emergencies, administration of anesthesia and nursing
      procedures. As long as the desired humanistic values were assured, South African 
      authorities have preferred to complement these competencies. Thus, since 2003,
      the Medical University of Villa Clara has applied a curricular strategy of 12
      complementary courses to develop the requested additional skills, but results
      have not met expectations. OBJECTIVE: Determine why the complementary curricular 
      strategy has not been entirely successful and identify possible courses of action
      for improvement. METHODS: A document review was conducted of the curricular
      strategy applied and of minutes of meetings between Cuban and South African
      counterparts to identify correspondence between requested professional skills and
      actions to develop them. In addition, South African students were surveyed and
      Cuban professors were interviewed in depth. Senior university administrators and 
      key informants were also interviewed. Variables assessed were course quality and 
      satisfaction of students and professors. RESULTS: Some actions originally
      included in the curricular strategy were not implemented and there were
      structural weaknesses in complementary courses, primarily in objectives, teaching
      strategy and evaluation. Students reported insufficient practical activities and 
      lack of relationship between content and the health situation in South Africa.
      Professors were dissatisfied with student levels of motivation and ability to
      manage their own learning. Other influencing factors were insufficient academic
      management and professors' lack of knowledge about the context where these future
      professionals would eventually practice. CONCLUSIONS: Curricular strategy
      deficiencies detected are primarily in academic management; overcoming them could
      facilitate action in specific directions identified to improve the requested
      skill levels.
FAU - Quintana, Frank
AU  - Quintana F
AD  - Medical University of Villa Clara, Santa Clara, Cuba.
FAU - Sarasa, Nelida L
AU  - Sarasa NL
FAU - Canizares, Oscar
AU  - Canizares O
FAU - Huguet, Yayly
AU  - Huguet Y
LA  - eng
PT  - Journal Article
PL  - United States
TA  - MEDICC Rev
JT  - MEDICC review
JID - 100964771
SB  - IM
CIN - MEDICC Rev. 2013 Jan;15(1):5. PMID: 23520657
MH  - Competency-Based Education/methods/organization & administration
MH  - Cuba
MH  - *Cultural Competency
MH  - Curriculum
MH  - Education, Medical/methods/*organization & administration
MH  - Faculty, Medical
MH  - General Practitioners/*education
MH  - Humans
MH  - International Educational Exchange
MH  - Interviews as Topic
MH  - Needs Assessment
MH  - Program Evaluation
MH  - Qualitative Research
MH  - South Africa/ethnology
MH  - Students, Medical/*psychology
EDAT- 2012/08/08 06:00
MHDA- 2012/12/27 06:00
CRDT- 2012/08/08 06:00
PHST- 2012/08/08 06:00 [entrez]
PHST- 2012/08/08 06:00 [pubmed]
PHST- 2012/12/27 06:00 [medline]
AID - 10.37757/MR2012V14.N3.4 [doi]
PST - ppublish
SO  - MEDICC Rev. 2012 Jul;14(3):19-24. doi: 10.37757/MR2012V14.N3.4.


PMID- 22868961
OWN - NLM
STAT- MEDLINE
DCOM- 20121012
LR  - 20181201
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 345
DP  - 2012 Aug 6
TI  - Whole System Demonstrator trial: policy, politics, and publication ethics.
PG  - e5280; author reply e5305
LID - 10.1136/bmj.e5280 [doi]
LID - bmj.e5280 [pii]
FAU - Greenhalgh, Trisha
AU  - Greenhalgh T
LA  - eng
PT  - Letter
PT  - Comment
DEP - 20120806
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
SB  - IM
CON - BMJ. 2012;344:e3874. PMID: 22723612
MH  - Emergency Service, Hospital/*statistics & numerical data
MH  - Female
MH  - *General Practice
MH  - Hospitalization/*statistics & numerical data
MH  - Humans
MH  - Male
MH  - *Mortality
MH  - *Telemedicine
EDAT- 2012/08/08 06:00
MHDA- 2012/10/13 06:00
CRDT- 2012/08/08 06:00
PHST- 2012/08/08 06:00 [entrez]
PHST- 2012/08/08 06:00 [pubmed]
PHST- 2012/10/13 06:00 [medline]
AID - 10.1136/bmj.e5280 [doi]
PST - epublish
SO  - BMJ. 2012 Aug 6;345:e5280; author reply e5305. doi: 10.1136/bmj.e5280.


PMID- 22868549
OWN - NLM
STAT- MEDLINE
DCOM- 20120913
LR  - 20120807
IS  - 1080-2371 (Print)
IS  - 1080-2371 (Linking)
VI  - 18
IP  - 4
DP  - 2012 Aug
TI  - Treatment of refractory headache: potential conflicts of interest in coding.
PG  - 896-9
LID - 10.1212/01.CON.0000418650.62526.b1 [doi]
AB  - Issues directly or indirectly related to the increasing costs of health care
      services have the potential to adversely affect physicians' fiduciary
      responsibilities to their patients. Coding deception in response to perceived
      unfairness in reimbursement practices represents one of these potential adverse
      influences. This case discussion addresses the potential motivations underlying
      coding deception and the reasons it cannot be supported from either a legal or
      ethical perspective.
FAU - Kornbluth, Joshua A
AU  - Kornbluth JA
AD  - The Johns Hopkins Hospital, Department of Neurology, Baltimore, MD, USA.
      jkornbl2@jhmi.edu
FAU - Russell, James A
AU  - Russell JA
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Continuum (Minneap Minn)
JT  - Continuum (Minneapolis, Minn.)
JID - 9509333
SB  - IM
MH  - Adult
MH  - Clinical Coding/*ethics
MH  - *Conflict of Interest
MH  - *Ethics, Medical
MH  - Female
MH  - Headache/diagnosis/therapy
MH  - Health Care Costs/*ethics
MH  - Humans
EDAT- 2012/08/08 06:00
MHDA- 2012/09/14 06:00
CRDT- 2012/08/08 06:00
PHST- 2012/08/08 06:00 [entrez]
PHST- 2012/08/08 06:00 [pubmed]
PHST- 2012/09/14 06:00 [medline]
AID - 10.1212/01.CON.0000418650.62526.b1 [doi]
AID - 00132979-201208000-00016 [pii]
PST - ppublish
SO  - Continuum (Minneap Minn). 2012 Aug;18(4):896-9. doi:
      10.1212/01.CON.0000418650.62526.b1.


PMID- 22867960
OWN - NLM
STAT- MEDLINE
DCOM- 20130930
LR  - 20220318
IS  - 1488-2361 (Electronic)
IS  - 0846-5371 (Linking)
VI  - 64
IP  - 3
DP  - 2013 Aug
TI  - Ethics in radiology: wait lists queue jumping.
PG  - 170-5
LID - 10.1016/j.carj.2011.12.006 [doi]
LID - S0846-5371(11)00167-7 [pii]
AB  - Education in ethics is a requirement for all Royal College residency training
      programs as laid out in the General Standards of Accreditation for residency
      programs in Canada. The ethical challenges that face radiologists in clinical
      practice are often different from those that face other physicians, because the
      nature of the physician-patient interaction is unlike that of many other
      specialties. Ethics education for radiologists and radiology residents will
      benefit from the development of teaching materials and resources that focus on
      the issues that are specific to the specialty. This article is intended to serve 
      as an educational resource for radiology training programs to facilitate teaching
      ethics to residents and also as a continuing medical education resource for
      practicing radiologists. In an environment of limited health care resources,
      radiologists are frequently asked to expedite imaging studies for patients and,
      in some respects, act as gatekeepers for specialty care. The issues of wait
      lists, queue jumping, and balancing the needs of individuals and society are
      explored from the perspective of a radiologist.
CI  - Copyright (c) 2013 Canadian Association of Radiologists. Published by Elsevier
      Inc. All rights reserved.
FAU - Cunningham, Natalie
AU  - Cunningham N
AD  - Department of Diagnostic Imaging, Dalhousie University, Halifax, Nova Scotia,
      Canada.
FAU - Reid, Lynette
AU  - Reid L
FAU - MacSwain, Sarah
AU  - MacSwain S
FAU - Clarke, James R
AU  - Clarke JR
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120804
PL  - United States
TA  - Can Assoc Radiol J
JT  - Canadian Association of Radiologists journal = Journal l'Association canadienne
      des radiologistes
JID - 8812910
SB  - IM
MH  - Canada
MH  - Education, Medical, Continuing/ethics/methods
MH  - *Ethics, Medical
MH  - Humans
MH  - Internship and Residency/ethics/methods
MH  - Radiology/*education/*ethics
MH  - *Waiting Lists
OTO - NOTNLM
OT  - CanMEDs
OT  - Education
OT  - Ethics
OT  - Wait lists
EDAT- 2012/08/08 06:00
MHDA- 2013/10/01 06:00
CRDT- 2012/08/08 06:00
PHST- 2011/04/27 00:00 [received]
PHST- 2011/11/10 00:00 [revised]
PHST- 2011/12/17 00:00 [accepted]
PHST- 2012/08/08 06:00 [entrez]
PHST- 2012/08/08 06:00 [pubmed]
PHST- 2013/10/01 06:00 [medline]
AID - S0846-5371(11)00167-7 [pii]
AID - 10.1016/j.carj.2011.12.006 [doi]
PST - ppublish
SO  - Can Assoc Radiol J. 2013 Aug;64(3):170-5. doi: 10.1016/j.carj.2011.12.006. Epub
      2012 Aug 4.


PMID- 22867865
OWN - NLM
STAT- MEDLINE
DCOM- 20121121
LR  - 20161125
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 75
IP  - 9
DP  - 2012 Nov
TI  - Involving citizens in the ethics of biobank research: informing institutional
      policy through structured public deliberation.
PG  - 1604-11
LID - 10.1016/j.socscimed.2012.06.026 [doi]
AB  - This paper reports on the design, implementation, and results of a structured
      public deliberation on human tissue biobanking conducted in Vancouver, Canada, in
      2009. This study builds on previous work on the use of deliberative democratic
      principles and methods to engage publics on the social and ethical implications
      of human tissue biobanking. In a significant refinement of methods, we focus on
      providing public input to institutional practice and governance of biobanks using
      a tailored workbook structure to guide participants' discussion. Our focus is on 
      the local context and practices of a particular institution, the BC BioLibrary.
      However, elements of both the methodological innovations and the ethical guidance
      implied by our findings are generalisable for biobanking internationally.
      Recommendations from the deliberative forum include issues of informed consent,
      privacy protections, collection of biospecimens, governance of biobanks, and how 
      to manage the process of introduction between biobanks and potential donors.
      Notable findings include public support for research use of anonymised
      un-consented tissue samples when these come from archived collections, but lack
      of support when they are collected prospectively.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - O'Doherty, Kieran C
AU  - O'Doherty KC
AD  - Department of Psychology, University of Guelph, Guelph, ON, Canada, N1G 2W1.
      kieran.odoherty@uoguelph.ca
FAU - Hawkins, Alice K
AU  - Hawkins AK
FAU - Burgess, Michael M
AU  - Burgess MM
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120728
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Canada
MH  - *Community Participation
MH  - Humans
MH  - *Organizational Policy
MH  - Tissue Banks/ethics/*organization & administration
EDAT- 2012/08/08 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/08/08 06:00
PHST- 2011/12/14 00:00 [received]
PHST- 2012/06/19 00:00 [revised]
PHST- 2012/06/27 00:00 [accepted]
PHST- 2012/08/08 06:00 [entrez]
PHST- 2012/08/08 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - S0277-9536(12)00536-9 [pii]
AID - 10.1016/j.socscimed.2012.06.026 [doi]
PST - ppublish
SO  - Soc Sci Med. 2012 Nov;75(9):1604-11. doi: 10.1016/j.socscimed.2012.06.026. Epub
      2012 Jul 28.


PMID- 22866822
OWN - NLM
STAT- MEDLINE
DCOM- 20130225
LR  - 20211021
IS  - 1747-5341 (Electronic)
IS  - 1747-5341 (Linking)
VI  - 7
DP  - 2012 Aug 6
TI  - Engaging with research ethics in central Francophone Africa: reflections on a
      workshop about ancillary care.
PG  - 10
AB  - Research ethics is predominantly taught and practiced in Anglophone countries,
      particularly those in North America and Western Europe. Initiatives to build
      research ethics capacity in developing countries must attempt to avoid imposing
      foreign frameworks and engage with ethical issues in research that are locally
      relevant. This article describes the process and outcomes of a capacity-building 
      workshop that took place in Kinshasa, Democratic Republic of Congo in the summer 
      of 2011. Although the workshop focused on a specific ethical theme - the
      responsibilities of researchers to provide health-related care to their research 
      participants - we argue that the structure of the workshop offers a useful method
      for engaging with research ethics in general, and the theme of ancillary care
      encourages a broad perspective on research ethics that is highly pertinent in
      low-income countries. The workshop follows an interactive, locally driven model
      that could be fruitfully replicated in similar settings.
FAU - Tshikala, Tomi
AU  - Tshikala T
AD  - UNC Center for Bioethics, Universtity of North Carolina, Chapel Hill, NC, USA.
FAU - Mupenda, Bavon
AU  - Mupenda B
FAU - Dimany, Pierre
AU  - Dimany P
FAU - Malonga, Aime
AU  - Malonga A
FAU - Ilunga, Vicky
AU  - Ilunga V
FAU - Rennie, Stuart
AU  - Rennie S
LA  - eng
GR  - R25 TW007098/TW/FIC NIH HHS/United States
GR  - R25-TW 7098/TW/FIC NIH HHS/United States
PT  - Editorial
PT  - Research Support, N.I.H., Extramural
DEP - 20120806
PL  - England
TA  - Philos Ethics Humanit Med
JT  - Philosophy, ethics, and humanities in medicine : PEHM
JID - 101258058
SB  - IM
MH  - Africa
MH  - Capacity Building/*organization & administration
MH  - *Developing Countries
MH  - Education
MH  - Education, Medical
MH  - Educational Status
MH  - *Ethics, Research
MH  - France
MH  - Health Services Accessibility
MH  - Health Services Needs and Demand
MH  - Humans
MH  - Models, Organizational
PMC - PMC3447659
EDAT- 2012/08/08 06:00
MHDA- 2013/02/26 06:00
CRDT- 2012/08/08 06:00
PHST- 2011/11/24 00:00 [received]
PHST- 2012/07/31 00:00 [accepted]
PHST- 2012/08/08 06:00 [entrez]
PHST- 2012/08/08 06:00 [pubmed]
PHST- 2013/02/26 06:00 [medline]
AID - 1747-5341-7-10 [pii]
AID - 10.1186/1747-5341-7-10 [doi]
PST - epublish
SO  - Philos Ethics Humanit Med. 2012 Aug 6;7:10. doi: 10.1186/1747-5341-7-10.


PMID- 22866557
OWN - NLM
STAT- MEDLINE
DCOM- 20120911
LR  - 20131106
IS  - 1351-5578 (Print)
IS  - 1351-5578 (Linking)
VI  - 19
IP  - 4
DP  - 2012
TI  - Regional follow up of late preterm neonatal intensive care graduates.
PG  - 37-43
AB  - AIM: To guide researchers who are contemplating embarking on research by
      discussing the methodological challenges encountered in a retrospective follow-up
      study of three-year-old, late preterm infants (LPIs) who received neonatal
      intensive care (NIC) in Northern Ireland in 2006. BACKGROUND: The importance of
      effective research examining the longer term outcomes of infants admitted to NIC 
      has received increasing recognition. Follow-up cohort and longitudinal studies
      have grown in number globally, yet the research methodology relating to follow up
      of NIC graduates is unclear. DATA SOURCES: Neonatal Intensive Care Outcomes and
      Research Evaluation (NICORE) database; maternity unit delivery records. REVIEW
      METHODS: This is a reflective-practice methodology paper. DISCUSSION: This paper 
      highlights the methodological challenges of conducting retrospective follow-up
      research, from the initial planning stages through to the collection of data from
      the children, including identification of infants from a retrospective database, 
      ethical issues, child-safety concerns and recruitment challenges. CONCLUSION: The
      important lessons learned from this study were that: Input from a
      multidisciplinary team is central to the success of the study. Protocols and
      guidelines should be in place before the study to ensure that problems are dealt 
      with quickly. A realistic timeframe for each phase and ongoing monitoring of
      recruitment rates are essential. IMPLICATIONS FOR RESEARCH/PRACTICE: This paper
      creates an awareness of potential issues that may arise in follow-up research
      with NIC graduates. The paper also offers practical and effective examples of
      dealing with these issues, helping to ensure the smooth running of an ethical,
      professionally conducted, methodologically sound and clinically relevant
      follow-up study.
FAU - Doran, Jackie
AU  - Doran J
AD  - School of Nursing and Midwifery, Queen's University, Belfast.
      jackie.doran@qub.ac.uk
FAU - McGowan, Jenny E
AU  - McGowan JE
FAU - Alderdice, Fiona
AU  - Alderdice F
FAU - McCall, Emma
AU  - McCall E
FAU - Craig, Stanley
AU  - Craig S
FAU - Jenkins, John
AU  - Jenkins J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nurse Res
JT  - Nurse researcher
JID - 9435953
MH  - *Follow-Up Studies
MH  - Humans
MH  - Infant, Newborn
MH  - *Infant, Premature
MH  - Informed Consent
MH  - *Intensive Care, Neonatal
MH  - Northern Ireland
MH  - Nursing Research/ethics/*methods/organization & administration
MH  - Patient Selection
MH  - Peer Review, Research
MH  - *Research Design
MH  - Retrospective Studies
EDAT- 2012/08/08 06:00
MHDA- 2012/09/12 06:00
CRDT- 2012/08/08 06:00
PHST- 2012/08/08 06:00 [entrez]
PHST- 2012/08/08 06:00 [pubmed]
PHST- 2012/09/12 06:00 [medline]
AID - 10.7748/nr2012.07.19.4.37.c9223 [doi]
PST - ppublish
SO  - Nurse Res. 2012;19(4):37-43. doi: 10.7748/nr2012.07.19.4.37.c9223.


PMID- 22866555
OWN - NLM
STAT- MEDLINE
DCOM- 20120911
LR  - 20161125
IS  - 1351-5578 (Print)
IS  - 1351-5578 (Linking)
VI  - 19
IP  - 4
DP  - 2012
TI  - Parental involvement in neonatal pain management: reflecting on the
      researcher-practitioner role.
PG  - 27-30
AB  - AIM: The objective of this paper is to identify and explore some of the ethical
      and professional issues facing the clinical researcher-practitioner and to
      discuss how these were addressed in one particular study. BACKGROUND: The
      author's experience of undertaking ethnographic research in the organisation in
      which she works as a nurse consultant highlighted a number of ethical and
      professional dilemmas. This paper discusses how some of these issues,
      particularly relating to informed consent, confidentiality, practice concerns and
      exploitation were addressed. DATA SOURCES: Doctoral research (DMedSCi) with
      Sheffield University. DISCUSSION: This paper discusses the ethical and
      professional dilemmas and some of the advantages associated with the
      researcher-practitioner role. CONCLUSION: This paper identifies and discusses the
      need to: Remember who the research is about and whom it should benefit. Include a
      wide research team. Acknowledge the researcher's responsibility towards the
      participants. Identify and act on problems as they arise. IMPLICATION FOR
      RESEARCH/PRACTICE: The need to keep the participant as the focus of the research,
      to involve a wide research team and to reflect constantly on the process.
FAU - Skene, Caryl
AU  - Skene C
AD  - Jessop Wing Neonatal Unit, Sheffield Teaching Hospitals NHS Trust, Sheffield, UK.
      caryl.skene@sth.nhs.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurse Res
JT  - Nurse researcher
JID - 9435953
MH  - Anthropology, Cultural/*ethics/methods
MH  - Beneficence
MH  - Clinical Nursing Research/*ethics/methods
MH  - Confidentiality/ethics
MH  - Humans
MH  - Infant, Newborn
MH  - Informed Consent/ethics
MH  - *Neonatal Nursing
MH  - Pain Management/nursing
MH  - *Professional Role
MH  - *Professional-Family Relations
MH  - United Kingdom
EDAT- 2012/08/08 06:00
MHDA- 2012/09/12 06:00
CRDT- 2012/08/08 06:00
PHST- 2012/08/08 06:00 [entrez]
PHST- 2012/08/08 06:00 [pubmed]
PHST- 2012/09/12 06:00 [medline]
AID - 10.7748/nr2012.07.19.4.27.c9221 [doi]
PST - ppublish
SO  - Nurse Res. 2012;19(4):27-30. doi: 10.7748/nr2012.07.19.4.27.c9221.


PMID- 22866552
OWN - NLM
STAT- MEDLINE
DCOM- 20120911
LR  - 20120807
IS  - 1351-5578 (Print)
IS  - 1351-5578 (Linking)
VI  - 19
IP  - 4
DP  - 2012
TI  - A personal insight into researcher positionality.
PG  - 11-4
AB  - AIM: To highlight observations on the dilemmas of insider research. BACKGROUND:
      Researchers in qualitative research have traditionally been thought of as
      positioned inside or outside the social group being studied. However, there is
      recognition of the blurring of the apparent Separation between these two
      positions. This paper discusses the ethical and methodological dilemmas involved 
      as an 'insider' when negotiating access to the field and recruiting participants.
      REVIEW METHODS: This is a reflective paper. CONCLUSION: The personal insight into
      researcher positionality provided in this paper shows that qualitative
      researchers need to consider carefully the potential risks to participants when
      conducting insider research.
FAU - Moore, Jenny
AU  - Moore J
AD  - School of Nursing Sciences, University of East Anglia, Norwich, UK.
      j.f.moore@uea.ac.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurse Res
JT  - Nurse researcher
JID - 9435953
MH  - Humans
MH  - *Interpersonal Relations
MH  - Nursing Research/ethics/*methods
MH  - Patient Selection
MH  - *Qualitative Research
MH  - *Self Disclosure
MH  - *Social Behavior
EDAT- 2012/08/08 06:00
MHDA- 2012/09/12 06:00
CRDT- 2012/08/08 06:00
PHST- 2012/08/08 06:00 [entrez]
PHST- 2012/08/08 06:00 [pubmed]
PHST- 2012/09/12 06:00 [medline]
AID - 10.7748/nr2012.07.19.4.11.c9218 [doi]
PST - ppublish
SO  - Nurse Res. 2012;19(4):11-4. doi: 10.7748/nr2012.07.19.4.11.c9218.


PMID- 22847090
OWN - NLM
STAT- MEDLINE
DCOM- 20121015
LR  - 20130925
IS  - 2163-0763 (Electronic)
IS  - 2163-0755 (Linking)
VI  - 73
IP  - 2 Suppl 1
DP  - 2012 Aug
TI  - The Battlefield Health and Trauma Research Institute Scientific Ethics Committee:
      an evolving model for fostering a culture of integrity.
PG  - S3-6
LID - 10.1097/TA.0b013e3182605f9e [doi]
FAU - Ryan, Kathy L
AU  - Ryan KL
AD  - US Army Institute of Surgical Research, Fort Sam Houston, Texas 78234, USA.
      Kathy.l.ryan@us.army.mil
FAU - Blackbourne, Lorne H
AU  - Blackbourne LH
FAU - Cancio, Leopoldo C
AU  - Cancio LC
FAU - Dunn, William J
AU  - Dunn WJ
FAU - Jordan, Bryan S
AU  - Jordan BS
FAU - McClinton, Annette R
AU  - McClinton AR
FAU - Nelson, Betty S
AU  - Nelson BS
FAU - Rathbone, Christopher R
AU  - Rathbone CR
FAU - Ross, James D
AU  - Ross JD
FAU - Kragh, John F
AU  - Kragh JF
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
PL  - United States
TA  - J Trauma Acute Care Surg
JT  - The journal of trauma and acute care surgery
JID - 101570622
SB  - IM
MH  - Academies and Institutes/*standards
MH  - Ethics Committees, Research/*standards
MH  - *Ethics, Research
MH  - Humans
MH  - Military Medicine/*standards
MH  - Models, Organizational
MH  - Wounds and Injuries/surgery
EDAT- 2012/08/08 06:00
MHDA- 2012/10/16 06:00
CRDT- 2012/08/01 06:00
PHST- 2012/08/01 06:00 [entrez]
PHST- 2012/08/08 06:00 [pubmed]
PHST- 2012/10/16 06:00 [medline]
AID - 10.1097/TA.0b013e3182605f9e [doi]
AID - 01586154-201208001-00002 [pii]
PST - ppublish
SO  - J Trauma Acute Care Surg. 2012 Aug;73(2 Suppl 1):S3-6. doi:
      10.1097/TA.0b013e3182605f9e.


PMID- 25254160
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140925
LR  - 20211021
IS  - 2219-2808 (Print)
IS  - 2219-2808 (Linking)
VI  - 1
IP  - 2
DP  - 2012 Aug 8
TI  - Clinical pharmacological studies in children: From exploratory towards
      confirmation driven methodology.
PG  - 3-7
LID - 10.5409/wjcp.v1.i2.3 [doi]
AB  - Just like children are not small adults, pediatric studies are not just
      subgroup-adult studies. Clinical pharmacology aims to predict these effects based
      on drug, population and/or patient-specific pharmacokinetics (concentration-time 
      profiles) and -dynamics (concentration-effect profile). The most essential
      characteristics of childhood are growth and maturation. Both phenomena are most
      prominent during infancy making the claim that "an infant is not just a small
      child" as relevant compared to the paradigm that "a child is not just a small
      adult". From a clinical pharmacology perspective, the consequence of such a
      dynamic setting is extensive variability throughout childhood in both the
      pharmacokinetics and pharmacodynamics. Trial design probably has impact on
      recruitment to an even greater extent compared to adult studies. In general, if a
      study is designed well, with a clear clinical question with which parents and
      children can identify, they are likely to consider participation. Open
      communication with all stakeholders involved will most likely result in ethically
      correct, practically feasible, scientifically sound, and economical reasonable
      studies to provide children with the appropriate treatment. From an academic
      perspective, feasibility, relevance, applicability and costs of clinical
      pharmacological studies in children can be significantly improved by new sampling
      concepts (e.g., saliva, urine, dried spot blood) and the systematic introduction 
      of already known information into the trial design through model based pediatric 
      drug development, that mainly affect feasibility of pharmacokinetic studies. In
      contrast, for the pharmacodynamic part of pediatric studies, development and
      validation of population specific biomarkers or robust outcome variables is
      urgently needed.
FAU - Allegaert, Karel
AU  - Allegaert K
AD  - Karel Allegaert, Division of Woman and Child, Neonatal Intensive Care Unit,
      University Hospital, 3000 Leuven, Belgium.
LA  - eng
PT  - Journal Article
DEP - 20120808
PL  - United States
TA  - World J Clin Pediatr
JT  - World journal of clinical pediatrics
JID - 101627548
PMC - PMC4145636
OTO - NOTNLM
OT  - Child
OT  - Developmental pharmacology
OT  - Infant
OT  - Pharmacodynamics
OT  - Pharmacokinetics
OT  - Trial design
EDAT- 2012/08/08 00:00
MHDA- 2012/08/08 00:01
CRDT- 2014/09/26 06:00
PHST- 2012/02/04 00:00 [received]
PHST- 2012/07/31 00:00 [revised]
PHST- 2012/08/05 00:00 [accepted]
PHST- 2014/09/26 06:00 [entrez]
PHST- 2012/08/08 00:00 [pubmed]
PHST- 2012/08/08 00:01 [medline]
AID - 10.5409/wjcp.v1.i2.3 [doi]
PST - epublish
SO  - World J Clin Pediatr. 2012 Aug 8;1(2):3-7. doi: 10.5409/wjcp.v1.i2.3. eCollection
      2012 Aug 8.


PMID- 22866239
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 2150-7716 (Print)
IS  - 2150-7724 (Linking)
VI  - 3
IP  - 3
DP  - 2012
TI  - Barriers to Considering Ethical and Societal Implications of Research:
      Perceptions of Life Scientists.
PG  - 40-50
AB  - BACKGROUND: As part of an empirical study investigating how life scientists think
      about ethical and societal implications of their work, and about life science
      research in general, we sought to elucidate barriers that scientists might face
      in considering such implications. METHOD: Between 2005 and 2007, we conducted a
      study consisting of phone interviews, focus groups, and a national survey of life
      scientists at biomedical research institutions. The study population included
      graduate students, postdoctoral fellows, faculty, clinical instructors, and
      research staff. We analyzed data through qualitative and quantitative methods.
      RESULTS: In analyzing the data, we found that life scientists do, in fact, face
      barriers to considering ethical and societal implications of research. We
      categorized these barriers as falling into four broad domains: (1) lack of
      awareness of ethical and societal implications; (2) lack of relevance of such
      concerns to their specific research; (3) self-confidence in their ability to
      resolve such concerns; and (4) aspects of the daily practice of science itself.
      CONCLUSIONS: Life science researchers experience elements inherent in their
      training and in the conduct of science as barriers to thinking about ethical and 
      societal implications related to their work. These findings suggest areas in
      which research ethics educators, bioethicists, and the scientific community can
      focus their efforts to improve social and ethical accountability in research.
FAU - McCormick, Jennifer Blair
AU  - McCormick JB
AD  - Mayo Clinic.
FAU - Boyce, Angie M
AU  - Boyce AM
FAU - Ladd, Jennifer M
AU  - Ladd JM
FAU - Cho, Mildred
AU  - Cho M
LA  - eng
GR  - P50 HG003389/HG/NHGRI NIH HHS/United States
PT  - Journal Article
DEP - 20120619
PL  - United States
TA  - AJOB Prim Res
JT  - AJOB primary research
JID - 101520734
PMC - PMC3409664
MID - NIHMS387330
EDAT- 2012/08/07 06:00
MHDA- 2012/08/07 06:01
CRDT- 2012/08/07 06:00
PHST- 2012/08/07 06:00 [entrez]
PHST- 2012/08/07 06:00 [pubmed]
PHST- 2012/08/07 06:01 [medline]
AID - 10.1080/21507716.2012.680651 [doi]
PST - ppublish
SO  - AJOB Prim Res. 2012;3(3):40-50. doi: 10.1080/21507716.2012.680651. Epub 2012 Jun 
      19.


PMID- 22866014
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1178-7074 (Electronic)
IS  - 1178-7074 (Linking)
VI  - 5
DP  - 2012
TI  - Multiple multilayer stents for thoracoabdominal aortic aneurysm: a possible new
      tool for aortic endovascular surgery.
PG  - 629-32
LID - 10.2147/IJGM.S33008 [doi]
AB  - PURPOSE: Endovascular surgery data are confirming the paramount role of modern
      endovascular tools for a safe and sure exclusion of thoracoabdominal lesions.
      CASE REPORT: A 57-year-old female presented with severe comorbidity affected by a
      58 mm thoracoabdominal aortic aneurysm (TAAA). After patient-informed consent and
      local Ethical Committee and Italian Public Health Ministry authorization, three
      multilayer stents were implanted in the thoracoabdominal aortic tract, obtaining 
      at a 20-month computed tomography scan follow up, a complete exclusion of the
      TAAA, with normal patency of visceral vessels. CONCLUSION: Multilayer stents can 
      be used in thoracoabdominal aortic aneurysm, with positive results.
FAU - Tolva, Valerio Stefano
AU  - Tolva VS
AD  - Surgical Department Istituto Auxologico Italiano IRCCS, Milan, Italy.
FAU - Bianchi, Paolo Guy
AU  - Bianchi PG
FAU - Cireni, Lea Valeria
AU  - Cireni LV
FAU - Lombardo, Alma
AU  - Lombardo A
FAU - Keller, Guido Carlo
AU  - Keller GC
FAU - Parati, Gianfranco
AU  - Parati G
FAU - Casana, Renato Maria
AU  - Casana RM
LA  - eng
PT  - Case Reports
DEP - 20120724
PL  - New Zealand
TA  - Int J Gen Med
JT  - International journal of general medicine
JID - 101515487
PMC - PMC3410721
OTO - NOTNLM
OT  - chimney technique
OT  - renal artery stenosis
OT  - thoracoabdominal aneurysm
OT  - vascular complication
EDAT- 2012/08/07 06:00
MHDA- 2012/08/07 06:01
CRDT- 2012/08/07 06:00
PHST- 2012/08/07 06:00 [entrez]
PHST- 2012/08/07 06:00 [pubmed]
PHST- 2012/08/07 06:01 [medline]
AID - 10.2147/IJGM.S33008 [doi]
AID - ijgm-5-629 [pii]
PST - ppublish
SO  - Int J Gen Med. 2012;5:629-32. doi: 10.2147/IJGM.S33008. Epub 2012 Jul 24.


PMID- 22865925
OWN - NLM
STAT- MEDLINE
DCOM- 20140113
LR  - 20130717
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 8
DP  - 2013 Aug
TI  - Is mandatory research ethics reviewing ethical?
PG  - 517-20
LID - 10.1136/medethics-2011-100274 [doi]
AB  - Review boards responsible for vetting the ethical conduct of research have been
      criticised for their costliness, unreliability and inappropriate standards when
      evaluating some non-medical research, but the basic value of mandatory ethical
      review has not been questioned. When the standards that review boards use to
      evaluate research proposals are applied to review board practices, it is clear
      that review boards do not respect researchers or each other, lack merit and
      integrity, are not just and are not beneficent. The few benefits of mandatory
      ethical review come at a much greater, but mainly hidden, social cost. It is time
      that responsibility for the ethical conduct of research is clearly transferred to
      researchers, except possibly in that small proportion of cases where prospective 
      research participants may be so intrinsically vulnerable that their well-being
      may need to be overseen.
FAU - Dyck, Murray
AU  - Dyck M
AD  - Griffith University, School of Applied Psychology, Gold Coast, Queensland,
      Australia. m.dyck@griffith.edu.au
FAU - Allen, Gary
AU  - Allen G
LA  - eng
PT  - Journal Article
DEP - 20120803
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
CIN - J Med Ethics. 2013 Aug;39(8):525-6. PMID: 23033478
CIN - J Med Ethics. 2013 Aug;39(8):521-4. PMID: 23236085
MH  - *Beneficence
MH  - Biomedical Research/*ethics
MH  - Clinical Governance/ethics/standards
MH  - Conflict of Interest
MH  - Ethical Analysis
MH  - Ethical Review
MH  - Ethics Committees, Research/*economics/*ethics/standards
MH  - *Ethics, Research
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Multicenter Studies as Topic/ethics
MH  - *Personal Autonomy
MH  - Reproducibility of Results
MH  - Research Personnel/*ethics
MH  - Research Subjects
MH  - Risk Management/ethics/standards
MH  - *Social Justice
MH  - Trust
EDAT- 2012/08/07 06:00
MHDA- 2014/01/15 06:00
CRDT- 2012/08/07 06:00
PHST- 2012/08/07 06:00 [entrez]
PHST- 2012/08/07 06:00 [pubmed]
PHST- 2014/01/15 06:00 [medline]
AID - medethics-2011-100274 [pii]
AID - 10.1136/medethics-2011-100274 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Aug;39(8):517-20. doi: 10.1136/medethics-2011-100274. Epub
      2012 Aug 3.


PMID- 22865672
OWN - NLM
STAT- MEDLINE
DCOM- 20130523
LR  - 20211021
IS  - 1527-974X (Electronic)
IS  - 1067-5027 (Linking)
VI  - 20
IP  - 1
DP  - 2013 Jan 1
TI  - Two open access, high-quality datasets from anesthetic records.
PG  - 180-3
LID - 10.1136/amiajnl-2012-001087 [doi]
AB  - OBJECTIVE: To provide a set of high-quality time-series physiologic and event
      data from anesthetic cases formatted in an easy-to-use structure. MATERIALS AND
      METHODS: With ethics committee approval, data from surgical operations under
      general anesthesia were collected, including physiologic data, drug
      administrations, events, and clinicians' comments. These data were de-identified,
      formatted in a combined CSV/XML structure and made publicly available. RESULTS:
      Two separate datasets were collected containing physiologic time-series data and 
      time-stamped events for 34 patients. For 20 patients, the data included 400
      physiologic signals collected over 20 h, 274 events, and 597 drug
      administrations. For 14 patients, the data included 23 physiologic signals
      collected over 69 h, with 286 time stamped comments. DISCUSSION: Data reuse
      potentially saves significant time and financial costs. However, there are few
      high-quality repositories for accessible physiologic data and clinical
      interventions from surgical cases. De-identifying records assists with overcoming
      problems of privacy and storing the data in a format which is easily manipulated 
      with computing resources facilitates access by the wider research community. It
      is hoped that additional high-quality data will be added. Future work includes
      developing tools to explore and visualize the data more efficiently, and
      establishing quality control measures. CONCLUSION: An approach to collecting and 
      storing high-quality datasets from surgical operations under anesthesia such that
      they can be easily accessed by others for use in research has been demonstrated.
FAU - Cumin, David
AU  - Cumin D
AD  - Centre for Medical and Health Science Education, University of Auckland,
      Auckland, New Zealand. d.cumin@auckland.ac.nz
FAU - Newton-Wade, Vanessa
AU  - Newton-Wade V
FAU - Harrison, Michael J
AU  - Harrison MJ
FAU - Merry, Alan F
AU  - Merry AF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120804
PL  - England
TA  - J Am Med Inform Assoc
JT  - Journal of the American Medical Informatics Association : JAMIA
JID - 9430800
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anesthesia, General/*statistics & numerical data
MH  - Arthroscopy
MH  - Biomedical Research/statistics & numerical data
MH  - *Confidentiality
MH  - *Electronic Health Records
MH  - Female
MH  - Humans
MH  - *Information Dissemination
MH  - Information Storage and Retrieval
MH  - Male
MH  - Middle Aged
MH  - New Zealand
MH  - Shoulder/surgery
MH  - Surgical Procedures, Operative/*statistics & numerical data
PMC - PMC3555334
EDAT- 2012/08/07 06:00
MHDA- 2013/05/25 06:00
CRDT- 2012/08/07 06:00
PHST- 2012/08/07 06:00 [entrez]
PHST- 2012/08/07 06:00 [pubmed]
PHST- 2013/05/25 06:00 [medline]
AID - amiajnl-2012-001087 [pii]
AID - 10.1136/amiajnl-2012-001087 [doi]
PST - ppublish
SO  - J Am Med Inform Assoc. 2013 Jan 1;20(1):180-3. doi: 10.1136/amiajnl-2012-001087. 
      Epub 2012 Aug 4.


PMID- 22865488
OWN - NLM
STAT- MEDLINE
DCOM- 20150820
LR  - 20181201
IS  - 2458-9446 (Electronic)
IS  - 1300-0012 (Linking)
VI  - 24
IP  - 2
DP  - 2012
TI  - The antinociceptive effects of systemic administration of tramadol, gabapentin
      and their combination on mice model of acute pain.
PG  - 49-55
LID - 10.5505/agri.2012.31032 [doi]
AB  - OBJECTIVES: The aim of the present study was to investigate the possible
      antinociceptive effects of systemic administration of tramadol and gabapentin
      either alone or in combination on acute pain models in mice. METHODS: After
      obtaining the approval of Animal Ethics Committee; 96 BALB/c albino male mice
      were divided into 12 groups: (I) control without injection, (II) control treated 
      with saline, (III)-(IV) mice treated with tramadol 10 mg/kg or 30 mg/kg,
      (V)-(VIII) mice treated with gabapentin; 30, 100, 200, 300 mg/kg respectively. In
      order to determine possible interactions between tramadol gabapentin and; mice
      received four different combinations of tramadol + gabapentin (30+30, 30+100,
      30+200 and 30+300 mg/kg) (Groups IX-XII respectively). Mice received 0.1 ml
      solution for every 10 g of their weight. The drug was injected into peritonea.
      Thirty minutes after the drug injection, tail-flick and hot-plate tests were
      conducted. RESULTS: Ten and 30 mg/kg tramadol produced dose dependent
      antinociceptive effect in tail-flick and hot plate tests. Gabapentin had no
      antinociceptive effect in the tail flick test except 300 mg/kg dose, and had dose
      dependent antinociceptive effect in hot-plate test. In both tests, various
      combinations of tramadol and gabapentin produced an antinociceptive effect that
      is greater than that produced by tramadol and gabapentin alone. But, just 30
      mg/kg tramadol + 300 mg/kg gabapentin combination caused statistically
      significant increase in both tests (p<0.05). CONCLUSION: When gabapentin and
      tramadol were used in combination, gabapentin had no additive antinociceptive
      effect except for 300 mg/kg in tail-flick and hot-plate tests. Tail-flick test
      showed that tramadol produced better antinociceptive effect than gabapentin.
FAU - Aydin, Osman Nuri
AU  - Aydin ON
AD  - Department of Anesthesiology and Reanimation/Algology, Adnan Menderes University 
      Faculty of Medicine, Aydin, Turkey. onaydin@superonline.com
FAU - Ek, Rauf Onur
AU  - Ek RO
FAU - Temocin, Sadun
AU  - Temocin S
FAU - Ugur, Bakiye
AU  - Ugur B
FAU - Alacam, Bilge
AU  - Alacam B
FAU - Sen, Selda
AU  - Sen S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Turkey
TA  - Agri
JT  - Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish
      Society of Algology
JID - 9426197
RN  - 0 (Amines)
RN  - 0 (Analgesics)
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Cyclohexanecarboxylic Acids)
RN  - 39J1LGJ30J (Tramadol)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - 6CW7F3G59X (Gabapentin)
SB  - IM
MH  - Acute Pain/*drug therapy
MH  - Amines/*administration & dosage/pharmacology
MH  - Analgesics/*administration & dosage/pharmacology
MH  - Analgesics, Opioid/administration & dosage/pharmacology
MH  - Animals
MH  - Cyclohexanecarboxylic Acids/*administration & dosage/pharmacology
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Drug Therapy, Combination
MH  - Gabapentin
MH  - Hot Temperature
MH  - Injections, Intraperitoneal
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Nociception/drug effects
MH  - Pain Measurement/drug effects
MH  - Random Allocation
MH  - Tramadol/*administration & dosage/pharmacology
MH  - gamma-Aminobutyric Acid/*administration & dosage/pharmacology
EDAT- 2012/08/07 06:00
MHDA- 2015/08/21 06:00
CRDT- 2012/08/07 06:00
PHST- 2012/08/07 06:00 [entrez]
PHST- 2012/08/07 06:00 [pubmed]
PHST- 2015/08/21 06:00 [medline]
AID - 10.5505/agri.2012.31032 [doi]
PST - ppublish
SO  - Agri. 2012;24(2):49-55. doi: 10.5505/agri.2012.31032.


PMID- 22865482
OWN - NLM
STAT- MEDLINE
DCOM- 20131112
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 18
IP  - 3
DP  - 2012 Sep
TI  - Ethical concepts and future challenges of neuroimaging: an Islamic perspective.
PG  - 509-18
LID - 10.1007/s11948-012-9386-3 [doi]
AB  - Neuroscience is advancing at a rapid pace, with new technologies and approaches
      that are creating ethical challenges not easily addressed by current ethical
      frameworks and guidelines. One fascinating technology is neuroimaging, especially
      functional Magnetic Resonance Imaging (fMRI). Although still in its infancy, fMRI
      is breaking new ground in neuroscience, potentially offering increased
      understanding of brain function. Different populations and faith traditions will 
      likely have different reactions to these new technologies and the ethical
      challenges they bring with them. Muslims are approximately one-fifth of world
      population and they have a specific and highly regulated ethical and moral code, 
      which helps them deal with scientific advances and decision making processes in
      an Islamically ethical manner. From this ethical perspective, in light of the
      relevant tenets of Islam, neuroimaging poses various challenges. The privacy of
      spirituality and the thought process, the requirement to put community interest
      before individual interest, and emphasis on conscious confession in legal
      situations are Islamic concepts that can pose a challenge for the use of
      something intrusive such as an fMRI. Muslim moral concepts such as There shall be
      no harm inflicted or reciprocated in Islam and Necessities overrule prohibitions 
      are some of the criteria that might appropriately be used to guide advancing
      neuroscience. Neuroscientists should be particularly prudent and well prepared in
      implementing neuroscience advances that are breaking new scientific and ethical
      ground. Neuroscientists should also be prepared to assist in setting the ethical 
      frameworks in place in advance of what might be perceived as runaway applications
      of technology.
FAU - Al-Delaimy, Wael K
AU  - Al-Delaimy WK
AD  - Department of Family and Preventive Medicine, University of California, La Jolla,
      San Diego, CA 92093-0628, USA. waldelaimy@ucsd.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120804
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
CIN - Sci Eng Ethics. 2012 Sep;18(3):519-28. PMID: 23054670
MH  - *Brain
MH  - *Culture
MH  - Humans
MH  - *Islam
MH  - Magnetic Resonance Imaging
MH  - Mental Processes
MH  - *Morals
MH  - Neuroimaging/*ethics
MH  - Neurosciences/*ethics
MH  - Residence Characteristics
MH  - *Spirituality
MH  - Technology/ethics
EDAT- 2012/08/07 06:00
MHDA- 2013/11/13 06:00
CRDT- 2012/08/07 06:00
PHST- 2008/04/02 00:00 [received]
PHST- 2012/06/05 00:00 [accepted]
PHST- 2012/08/07 06:00 [entrez]
PHST- 2012/08/07 06:00 [pubmed]
PHST- 2013/11/13 06:00 [medline]
AID - 10.1007/s11948-012-9386-3 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2012 Sep;18(3):509-18. doi: 10.1007/s11948-012-9386-3. Epub 2012 
      Aug 4.


PMID- 22865176
OWN - NLM
STAT- MEDLINE
DCOM- 20130425
LR  - 20161020
IS  - 1024-2708 (Print)
IS  - 1024-2708 (Linking)
VI  - 18
IP  - 4
DP  - 2012 Aug
TI  - Perceptions of professional attributes in medicine: a qualitative study in Hong
      Kong.
PG  - 318-24
AB  - OBJECTIVE. Medical professionalism has been widely discussed in western scholarly
      literature. However, since Hong Kong has a mixed Chinese-western culture, it
      remains uncertain whether Hong Kong health care professionals, medical students, 
      and patients see medical professionalism in exactly the same way as westerners.
      The objective of the present study was to explore perceptions of medical
      professionalism in Hong Kong. DESIGN. Individual semi-structured interviews.
      SETTING. Medical faculty preceptors, residents, interns, nurses, and students
      from the Li Ka Shing Faculty of Medicine of the University of Hong Kong. Subjects
      were recruited at an out-patient clinic of Queen Mary Hospital. PARTICIPANTS. We 
      interviewed 39 subjects, including six medical faculty preceptors, six hospital
      residents, four medical interns, eight nurses, eight out-patients, and seven
      medical students. The interviews were transcribed and coded. Grounded theory was 
      employed for framing and analysing the interviews. RESULTS. A total of 30 primary
      themes were identified and grouped under three secondary themes, ie 'Expectations
      of a professional doctor', 'Work values', and 'Patient care'. In general, the
      primary themes were consistent with recognised professional attributes in western
      bioethics, such as knowledge and skills, holistic care, and communication skills.
      A closer analysis suggested that traditional Chinese thought also played an
      important role in shaping the medical professionalism of Hong Kong. Challenges to
      be faced by Hong Kong doctors due to recent social changes were also identified. 
      CONCLUSIONS. Medical professionalism in Hong Kong is shaped by both western
      medical ethics and traditional Chinese thought. The values treasured by Hong Kong
      health care professionals as well as technological advance, and the city's
      proximity to Mainland China makes Hong Kong health care unique. It is important
      to maintain the present work attitudes and at the same time adapt to new social
      changes.
FAU - Leung, Danny C
AU  - Leung DC
AD  - Medical Ethics Unit, Li Ka Shing Faculty of Medicine, The University of Hong
      Kong, Pokfulam, Hong Kong. dckleung2011@gmail.com
FAU - Hsu, Enoch K
AU  - Hsu EK
FAU - Hui, Edwin C
AU  - Hui EC
LA  - eng
PT  - Journal Article
PL  - China
TA  - Hong Kong Med J
JT  - Hong Kong medical journal = Xianggang yi xue za zhi
JID - 9512509
SB  - IM
MH  - *Clinical Competence
MH  - Communication
MH  - Hong Kong
MH  - Humans
MH  - Interviews as Topic
MH  - Patient Care
MH  - Perception
MH  - Physician-Patient Relations
MH  - *Qualitative Research
EDAT- 2012/08/07 06:00
MHDA- 2013/04/26 06:00
CRDT- 2012/08/07 06:00
PHST- 2012/08/07 06:00 [entrez]
PHST- 2012/08/07 06:00 [pubmed]
PHST- 2013/04/26 06:00 [medline]
PST - ppublish
SO  - Hong Kong Med J. 2012 Aug;18(4):318-24.


PMID- 22864986
OWN - NLM
STAT- MEDLINE
DCOM- 20130403
LR  - 20220311
IS  - 1534-6293 (Electronic)
IS  - 1528-4042 (Linking)
VI  - 12
IP  - 5
DP  - 2012 Oct
TI  - Assessing dementia in resource-poor regions.
PG  - 511-9
LID - 10.1007/s11910-012-0300-9 [doi]
AB  - The numbers and proportions of elderly are increasing rapidly in developing
      countries, where prevalence of dementia is often high. Providing cost-effective
      services for dementia sufferers and their caregivers in these resource-poor
      regions poses numerous challenges; developing resources for diagnosis must be the
      first step. Capacity building for diagnosis involves training and education of
      healthcare providers, as well as the general public, development of
      infrastructure, and resolution of economic and ethical issues. Recent progress in
      some low-to-middle-income countries (LMICs) provides evidence that partnerships
      between wealthy and resource-poor countries, and between developing countries,
      can improve diagnostic capabilities. Without the involvement of the mental health
      community of developed countries in such capacity-building programs, dementia in 
      the developing world is a disaster waiting to happen.
FAU - Maestre, Gladys E
AU  - Maestre GE
AD  - Laboratory of Neurosciences, University of Zulia, Edificio del Instituto de
      Enfermedades Cardiovasculares de la Universidad del Zulia, Primer Piso, Av
      Universidad diagonal al MACZUL, Maracaibo, 4002 Zulia, Venezuela.
      gem6@columbia.edu
LA  - eng
GR  - R01 AG036469/AG/NIA NIH HHS/United States
GR  - R01AG036469/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United States
TA  - Curr Neurol Neurosci Rep
JT  - Current neurology and neuroscience reports
JID - 100931790
SB  - IM
MH  - Capacity Building/*economics
MH  - Cost-Benefit Analysis
MH  - Dementia/diagnosis/*economics/therapy
MH  - *Developing Countries/economics
MH  - Health Personnel/*economics
MH  - Health Resources/*supply & distribution
MH  - Humans
PMC - PMC3434885
EDAT- 2012/08/07 06:00
MHDA- 2013/04/04 06:00
CRDT- 2012/08/07 06:00
PHST- 2012/08/07 06:00 [entrez]
PHST- 2012/08/07 06:00 [pubmed]
PHST- 2013/04/04 06:00 [medline]
AID - 10.1007/s11910-012-0300-9 [doi]
PST - ppublish
SO  - Curr Neurol Neurosci Rep. 2012 Oct;12(5):511-9. doi: 10.1007/s11910-012-0300-9.


PMID- 22864419
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 4
DP  - 2012
TI  - Evaluation of current Australian health service accreditation processes
      (ACCREDIT-CAP): protocol for a mixed-method research project.
LID - 10.1136/bmjopen-2012-001726 [doi]
LID - e001726 [pii]
AB  - INTRODUCTION: Accreditation programmes aim to improve the quality and safety of
      health services, and have been widely implemented. However, there is conflicting 
      evidence regarding the outcomes of existing programmes. The Accreditation
      Collaborative for the Conduct of Research, Evaluation and Designated
      Investigations through Teamwork-Current Accreditation Processes (ACCREDIT-CAP)
      project is designed to address key gaps in the literature by evaluating the
      current processes of three accreditation programmes used across Australian acute,
      primary and aged care services. METHODS AND DESIGN: The project comprises three
      mixed-method studies involving documentary analyses, surveys, focus groups and
      individual interviews. Study samples will comprise stakeholders from across the
      Australian healthcare system: accreditation agencies; federal and state
      government departments; consumer advocates; professional colleges and
      associations; and staff of acute, primary and aged care services. Sample sizes
      have been determined to ensure results allow robust conclusions. Qualitative
      information will be thematically analysed, supported by the use of textual
      grouping software. Quantitative data will be subjected to a variety of analytical
      procedures, including descriptive and comparative statistics. The results are
      designed to inform health system policy and planning decisions in Australia and
      internationally. ETHICS AND DISSEMINATION: The project has been approved by the
      University of New South Wales Human Research Ethics Committee (approval number
      HREC 10274). Results will be reported to partner organisations, healthcare
      consumers and other stakeholders via peer-reviewed publications, conference and
      seminar presentations, and a publicly accessible website.
FAU - Hinchcliff, Reece
AU  - Hinchcliff R
AD  - Centre for Clinical Governance Research, Australian Institute of Health
      Innovation, University of New South Wales, Sydney, New South Wales, Australia.
FAU - Greenfield, David
AU  - Greenfield D
FAU - Moldovan, Max
AU  - Moldovan M
FAU - Pawsey, Marjorie
AU  - Pawsey M
FAU - Mumford, Virginia
AU  - Mumford V
FAU - Westbrook, Johanna Irene
AU  - Westbrook JI
FAU - Braithwaite, Jeffrey
AU  - Braithwaite J
LA  - eng
PT  - Journal Article
DEP - 20120804
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3449274
EDAT- 2012/08/07 06:00
MHDA- 2012/08/07 06:01
CRDT- 2012/08/07 06:00
PHST- 2012/08/07 06:00 [entrez]
PHST- 2012/08/07 06:00 [pubmed]
PHST- 2012/08/07 06:01 [medline]
AID - bmjopen-2012-001726 [pii]
AID - 10.1136/bmjopen-2012-001726 [doi]
PST - epublish
SO  - BMJ Open. 2012 Aug 4;2(4). pii: bmjopen-2012-001726. doi:
      10.1136/bmjopen-2012-001726. Print 2012.


PMID- 22864378
OWN - NLM
STAT- MEDLINE
DCOM- 20121231
LR  - 20181201
IS  - 1536-0210 (Electronic)
IS  - 0020-9996 (Linking)
VI  - 47
IP  - 9
DP  - 2012 Sep
TI  - Anti-inflammatory drug evaluation in ApoE-/- mice by ultrasmall superparamagnetic
      iron oxide-enhanced magnetic resonance imaging.
PG  - 546-52
LID - 10.1097/RLI.0b013e3182631e68 [doi]
AB  - OBJECTIVES: The renin-angiotensin system and local phagocytic activity play a
      major role in atherosclerotic plaque development. Treatment with irbesartan, an
      antagonist of angiotensin II receptor, can decrease atherosclerotic lesion
      formation. Iron oxide-enhanced magnetic resonance imaging (MRI) can be
      successfully used to evaluate the phagocytic activity in the atherosclerotic
      plaque in mice. In this study, we used 2 iron oxide-enhanced MRI strategies, in
      vivo labeling by injection of iron oxide particles and injection of in vitro
      labeled macrophages, to investigate the effect of irbesartan on both
      atherosclerotic plaque size and macrophage content in apolipoprotein (Apo)
      E-deficient mice. MATERIALS AND METHODS: ApoE-/- female mice (C57BL/6 background;
      Charles-River, France) were divided into 2 groups (irbesartan treated [TG] or not
      treated [NTG]) and started on a high-fat diet (Harlan TD88137 Western Diet, 21%
      fat, 0.2% cholesterol). Animals underwent magnetic resonance examinations on a
      7-T scanner at baseline and at 14 and 28 weeks of treatment. At each time point, 
      2 MRI sessions were performed, before and 48 hours after administration of an
      iron oxide agent (P904; Guerbet, France) or magnetically labeled macrophages
      (Mcapital EF, CyrillicPhi). At the end of the follow-up, blood samples were taken
      for plasma lipid dosing and aorta samples for histology. The study was approved
      by the animal experimentation ethic committee of our institution.Vessel wall area
      measurements were performed on high-resolution spin echo transverse images.
      Multiecho gradient echo images acquired with the same geometry were used to
      calculate T2* maps of the vessel wall using a pixel-by-pixel monoexponential fit.
      Irbesartan effect on vessel wall area over time was assessed using a factorial
      analysis of variance test. T2* values of the vessel wall at pre- and
      post-ultrasmall superparamagnetic iron oxide (USPIO) administration were analyzed
      with a 1-way analysis of variance test with Bonferroni post hoc. RESULTS:
      Irbesartan treatment resulted in significantly smaller vessel wall areas at 28
      weeks of treatment (P = 0.04). Postinjection values varied significantly over
      time for both the NTG-P904 (P = 0.02) and the TG-P904 (P = 0.01) groups.
      Furthermore, when comparing the TG-P904 with the NTG-P904 group at 28 weeks of
      treatment, a significant difference was obtained for both pre- and post-USPIO
      administration values (P = 0.01). In the labeled-macrophage group, postinjection 
      T2* values were smaller than the preinjection ones for the NTG animals at 14
      weeks of treatment. No T2* changes were observed in the TG-MPhi group.The
      difference between pre- and post-USPIO administration T2* values (DeltaT2*) was
      significantly smaller in the TG-P904 group compared with the NTG-P904 group at 28
      weeks of treatment. At this point, a good correlation (R = 0.7, P = 0.03) was
      found between the DeltaT2* values in the P904 imaging group and the
      macrophage-covered area by immunohistological analysis. CONCLUSIONS: The present 
      study illustrates an MRI follow-up of intraplaque macrophages using in vivo
      labeling by iron oxide particle injection and macrophage injection after in vitro
      USPIO labeling in the assessment of a therapeutic effect in a mouse model of
      atherosclerosis. Even though in vivo labeling is not fully specific of macrophage
      uptake, it enabled the detection of a treatment-related reduction in the
      macrophage content of atherosclerotic plaques in ApoE-/- mice.
FAU - Sigovan, Monica
AU  - Sigovan M
AD  - Lyon University, CREATIS Laboratory, Lyon, France. monica.sigvan1@gmail.com
FAU - Kaye, Elena
AU  - Kaye E
FAU - Lancelot, Eric
AU  - Lancelot E
FAU - Corot, Claire
AU  - Corot C
FAU - Provost, Nicolas
AU  - Provost N
FAU - Majd, Zouher
AU  - Majd Z
FAU - Breisse, Magali
AU  - Breisse M
FAU - Canet-Soulas, Emmanuelle
AU  - Canet-Soulas E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Invest Radiol
JT  - Investigative radiology
JID - 0045377
RN  - 0 (Angiotensin II Type 1 Receptor Blockers)
RN  - 0 (Apolipoproteins E)
RN  - 0 (Biphenyl Compounds)
RN  - 0 (Contrast Media)
RN  - 0 (Magnetite Nanoparticles)
RN  - 0 (Tetrazoles)
RN  - 0 (apolipoprotein E1)
RN  - J0E2756Z7N (Irbesartan)
SB  - IM
MH  - Angiotensin II Type 1 Receptor Blockers/*pharmacology
MH  - Animals
MH  - Apolipoproteins E
MH  - Arteriosclerosis/diagnosis/*pathology
MH  - Biphenyl Compounds/*pharmacology
MH  - *Contrast Media
MH  - Disease Models, Animal
MH  - Disease Progression
MH  - Female
MH  - Irbesartan
MH  - Longitudinal Studies
MH  - Macrophages/drug effects
MH  - *Magnetic Resonance Imaging
MH  - *Magnetite Nanoparticles
MH  - Mice
MH  - Renin-Angiotensin System
MH  - Tetrazoles/*pharmacology
EDAT- 2012/08/07 06:00
MHDA- 2013/01/01 06:00
CRDT- 2012/08/07 06:00
PHST- 2012/08/07 06:00 [entrez]
PHST- 2012/08/07 06:00 [pubmed]
PHST- 2013/01/01 06:00 [medline]
AID - 10.1097/RLI.0b013e3182631e68 [doi]
AID - 00004424-201209000-00008 [pii]
PST - ppublish
SO  - Invest Radiol. 2012 Sep;47(9):546-52. doi: 10.1097/RLI.0b013e3182631e68.


PMID- 22864354
OWN - NLM
STAT- MEDLINE
DCOM- 20140610
LR  - 20190724
IS  - 1347-5231 (Electronic)
IS  - 0031-6903 (Linking)
VI  - 132
IP  - 8
DP  - 2012
TI  - [A research of letter color visibility in package insert information using
      simulator].
PG  - 945-51
AB  - Package insert of pharmaceutical drug is one of the most prioritized information 
      for pharmacists to secure safety of patients. However, the color of character,
      size, font and so on are various company by company product to product from a
      viewpoint of visibility. It may be cause a serious accident in case visibility is
      unclear, although it is the most important information. Moreover, package insert 
      with high visibility is required for color vision defectives from a viewpoint of 
      a universal design. Then, the authors selected the package insert which has the
      boxed warning in the ethical pharmaceutical currently stored mostly in the
      present health insurance pharmacy and quantified the red color using the color
      meter. We advocate the state of a suitable package insert from a viewpoint of a
      universal design, whether the red color is high visible or not for color vision
      defectives using simulator.
FAU - Kamimura, Naoki
AU  - Kamimura N
AD  - Faculty of Pharmaceutical Sciences, Tokyo University of Science (RIKADAI), Noda, 
      Chiba, Japan. kamimura@rs.noda.tus.ac.jp
FAU - Kinoshita, Noriyuki
AU  - Kinoshita N
FAU - Onaga, Midori
AU  - Onaga M
FAU - Watanabe, Yurika
AU  - Watanabe Y
FAU - Ijuin, Kazushige
AU  - Ijuin K
FAU - Shikamura, Yoshiaki
AU  - Shikamura Y
FAU - Negishi, Kenichi
AU  - Negishi K
FAU - Kaiho, Fusao
AU  - Kaiho F
FAU - Ohta, Takafumi
AU  - Ohta T
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Yakugaku Zasshi
JT  - Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
JID - 0413613
SB  - IM
MH  - Color
MH  - Humans
MH  - *Product Labeling/standards
MH  - *Vision, Ocular
MH  - Writing
EDAT- 2012/08/07 06:00
MHDA- 2014/06/11 06:00
CRDT- 2012/08/07 06:00
PHST- 2012/08/07 06:00 [entrez]
PHST- 2012/08/07 06:00 [pubmed]
PHST- 2014/06/11 06:00 [medline]
AID - DN/JST.JSTAGE/yakushi/132.945 [pii]
AID - 10.1248/yakushi.132.945 [doi]
PST - ppublish
SO  - Yakugaku Zasshi. 2012;132(8):945-51. doi: 10.1248/yakushi.132.945.


PMID- 22864295
OWN - NLM
STAT- MEDLINE
DCOM- 20121217
LR  - 20120806
IS  - 1550-5138 (Electronic)
IS  - 0887-9311 (Linking)
VI  - 26
IP  - 5
DP  - 2012 Sep-Oct
TI  - Ethical leadership.
PG  - 259-61
LID - 10.1097/HNP.0b013e318263f2da [doi]
AB  - In today's climate and environment, the conventional relationship between caring,
      economic, and administrative practices no longer serves the interest of patients,
      clinicians, or systems. A shift toward human caring values and an ethic of
      authentic healing relationships is required as systems now have to value human
      resources and life purposes, inner meaning, and processes for providers and
      patients alike. The costs of unethical behavior can be even greater for
      followers. When we assume the benefits of leadership, we also assume ethical
      burdens. It is the assertion and experience of the author that the triangle of
      ethics and ethical behavior, followers, and patient's outcomes are closely
      interrelated and affect each other in a very intimate and direct way. Unethical
      leadership may lead to follower disappointment and distrust, leading to lack of
      interest and commitment, consequently negatively impacting patient outcomes and
      organizational effectiveness.
FAU - Keselman, David
AU  - Keselman D
AD  - VP Ambulatory Care and Medical Affairs, Stanton Territorial Health Authority,
      Yellowknife, Canada. davidkeselman@hotmail.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Holist Nurs Pract
JT  - Holistic nursing practice
JID - 8702105
MH  - *Empathy
MH  - *Ethics, Professional
MH  - Humans
MH  - *Leadership
MH  - *Organizational Culture
MH  - Patient Care/*ethics
MH  - Social Values
EDAT- 2012/08/07 06:00
MHDA- 2012/12/18 06:00
CRDT- 2012/08/07 06:00
PHST- 2012/08/07 06:00 [entrez]
PHST- 2012/08/07 06:00 [pubmed]
PHST- 2012/12/18 06:00 [medline]
AID - 10.1097/HNP.0b013e318263f2da [doi]
AID - 00004650-201209000-00004 [pii]
PST - ppublish
SO  - Holist Nurs Pract. 2012 Sep-Oct;26(5):259-61. doi: 10.1097/HNP.0b013e318263f2da.


PMID- 22864090
OWN - NLM
STAT- MEDLINE
DCOM- 20130430
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 9
IP  - 3
DP  - 2012 Jul-Sep
TI  - Ethics of bedside clinics.
PG  - 219-20
FAU - Idiculla, Jyothi
AU  - Idiculla J
FAU - Mallela, Laviena
AU  - Mallela L
FAU - Krupa Tom, Francis
AU  - Krupa Tom F
FAU - Ravindran, G D
AU  - Ravindran GD
LA  - eng
PT  - Letter
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Education, Medical/*ethics
MH  - Humans
MH  - India
MH  - *Patient Rights
MH  - *Physician-Patient Relations
MH  - Teaching/*methods
EDAT- 2012/08/07 06:00
MHDA- 2013/05/01 06:00
CRDT- 2012/08/07 06:00
PHST- 2012/08/07 06:00 [entrez]
PHST- 2012/08/07 06:00 [pubmed]
PHST- 2013/05/01 06:00 [medline]
AID - http://ijme.in/203le216.html [pii]
AID - 10.20529/IJME.2012.076 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2012 Jul-Sep;9(3):219-20. doi: 10.20529/IJME.2012.076.


PMID- 22864085
OWN - NLM
STAT- MEDLINE
DCOM- 20130430
LR  - 20181201
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 9
IP  - 3
DP  - 2012 Jul-Sep
TI  - Proactive role for ethics committees.
PG  - 216
FAU - Kadam, Rashmi
AU  - Kadam R
LA  - eng
PT  - Letter
PT  - Comment
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
CON - Indian J Med Ethics. 2012 Jan-Mar;9(1):22-6. PMID: 22319848
MH  - *Ethics Committees, Research
MH  - *Ethics, Research
MH  - *Guideline Adherence
MH  - Humans
MH  - Informed Consent/*ethics
EDAT- 2012/08/07 06:00
MHDA- 2012/08/07 06:01
CRDT- 2012/08/07 06:00
PHST- 2012/08/07 06:00 [entrez]
PHST- 2012/08/07 06:00 [pubmed]
PHST- 2012/08/07 06:01 [medline]
AID - http://ijme.in/203le216.html [pii]
AID - 10.20529/IJME.2012.072 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2012 Jul-Sep;9(3):216. doi: 10.20529/IJME.2012.072.


PMID- 22864084
OWN - NLM
STAT- MEDLINE
DCOM- 20130430
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 9
IP  - 3
DP  - 2012 Jul-Sep
TI  - ICMR's ethical guidelines for biomedical research on human participants: need for
      clarification.
PG  - 207-9
AB  - The "Ethical guidelines for biomedical research on human participants" prepared
      by the Indian Council of Medical Research in 2006 came as a welcome step in the
      process of regulation of research on human subjects, since clear cut Indian
      guidelines were absent earlier. The guidelines have been accepted as the standard
      operating manual by Institutional Ethics Committees (IEC) in India. However, over
      a period of time, it has become obvious that the guidelines lack clarity in
      certain areas and require to be revised in the light of experiences of members in
      the IECs. Some of these problems with the ICMR guidelines have been highlighted
      in this paper to press for revision of the manual in the light of these
      experiences.
FAU - Ananthakrishnan, N
AU  - Ananthakrishnan N
AD  - Mahatma Gandhi Medical College and Research Institute, Pondicherry, India.
      n.ananthk@gmail.com
FAU - Shanthi, A K
AU  - Shanthi AK
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Ethics Committees, Research
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - India
MH  - Practice Guidelines as Topic
EDAT- 2012/08/07 06:00
MHDA- 2013/05/01 06:00
CRDT- 2012/08/07 06:00
PHST- 2012/08/07 06:00 [entrez]
PHST- 2012/08/07 06:00 [pubmed]
PHST- 2013/05/01 06:00 [medline]
AID - http://ijme.in/203eec207.html [pii]
AID - 10.20529/IJME.2012.067 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2012 Jul-Sep;9(3):207-9. doi: 10.20529/IJME.2012.067.


PMID- 22864081
OWN - NLM
STAT- MEDLINE
DCOM- 20130430
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 9
IP  - 3
DP  - 2012 Jul-Sep
TI  - Some ethical tradeoffs in mental health legislation and practice.
PG  - 196-9
AB  - An examination of the intersection of legal and medical discourses, particularly 
      in the realm of mental health legislation, provides a rich opportunity to clarify
      fundamental ethical conflicts. This essay studies one such legal discourse, the
      draft amendments to the Mental Health Act (1987), to demonstrate that the realm
      of ethical decision-making is constrained not only by pragmatic administrative,
      training and financial issues but also by the very contradictions that are
      necessarily at the heart of any ethically conducted project, however well
      intentioned and reasoned.
FAU - Govind, Nikhil
AU  - Govind N
AD  - Manipal Centre for Philosophy and the Humanities, Manipal University, Manipal,
      India. nikhilgovind@hotmail.com
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Commitment of Mentally Ill/legislation & jurisprudence
MH  - Forensic Psychiatry/*ethics
MH  - Human Rights/*legislation & jurisprudence
MH  - Humans
MH  - India
MH  - Legal Guardians/legislation & jurisprudence
MH  - Legislation as Topic/*ethics
MH  - Mental Disorders/rehabilitation
MH  - Mental Health Services/*ethics/*legislation & jurisprudence
MH  - Social Values
EDAT- 2012/08/07 06:00
MHDA- 2013/05/01 06:00
CRDT- 2012/08/07 06:00
PHST- 2012/08/07 06:00 [entrez]
PHST- 2012/08/07 06:00 [pubmed]
PHST- 2013/05/01 06:00 [medline]
AID - http://ijme.in/203co196.html [pii]
AID - 10.20529/IJME.2012.064 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2012 Jul-Sep;9(3):196-9. doi: 10.20529/IJME.2012.064.


PMID- 22864077
OWN - NLM
STAT- MEDLINE
DCOM- 20130430
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 9
IP  - 3
DP  - 2012 Jul-Sep
TI  - Healthcare the Ayurvedic way.
PG  - 177-9
AB  - Ayurveda, the indigenous medical system of India, has integrated the concept of
      interconnectedness into its understanding of health and disease. It considers the
      human body as an indivisible whole with a network of interrelated functions, mind
      and consciousness, wherein a disturbance in one part will have repercussions in
      other parts as well. The key to health is for these factors to maintain stability
      since disease is seen as a perturbation in this network. Ayurvedic treatment aims
      not only at removal of disease, but also at the restoration of the equilibrium of
      bodily functions. The centuries-old science of Ayurveda, apart from being a
      holistic form of medicine, also clearly defines the student-teacher and
      doctor-patient relationship. It sets high ethical standards of professional and
      personal integrity for the doctor, teacher and student. In addition to being
      technically skilled and well-read in the science, practitioners of Ayurveda must 
      be compassionate and empathetic. Students of Ayurveda are taught the importance
      of compassionate caring for patients and maintaining personal integrity.
FAU - Jayasundar, Rama
AU  - Jayasundar R
AD  - Department of NMR, All India Institute of Medical Sciences, New Delhi, India.
      ramajayasundar@hotmail.com
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Education, Medical
MH  - Ethics, Medical
MH  - Humans
MH  - India
MH  - *Medicine, Ayurvedic
MH  - Physician-Patient Relations
EDAT- 2012/08/07 06:00
MHDA- 2013/05/01 06:00
CRDT- 2012/08/07 06:00
PHST- 2012/08/07 06:00 [entrez]
PHST- 2012/08/07 06:00 [pubmed]
PHST- 2013/05/01 06:00 [medline]
AID - http://ijme.in/203dmh177.html [pii]
AID - 10.20529/IJME.2012.060 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2012 Jul-Sep;9(3):177-9. doi: 10.20529/IJME.2012.060.


PMID- 22863603
OWN - NLM
STAT- MEDLINE
DCOM- 20130328
LR  - 20220318
IS  - 1460-2350 (Electronic)
IS  - 0268-1161 (Linking)
VI  - 27
IP  - 11
DP  - 2012 Nov
TI  - Cell-free fetal DNA testing for fetal aneuploidy and beyond: clinical integration
      challenges in the US context.
PG  - 3123-31
LID - 10.1093/humrep/des286 [doi]
AB  - The recent release of new, non-invasive prenatal tests for fetal aneuploidy using
      cell-free fetal DNA (cffDNA) has been hailed as a revolution in prenatal testing 
      and has triggered significant commercial interest in the field. Ongoing research 
      portends the arrival of a wide range of cffDNA tests. However, it is not yet
      clear how these tests will be integrated into well-established prenatal testing
      strategies in the USA, as the timing of such testing and the degree to which new 
      non-invasive tests will supplement or replace existing screening and diagnostic
      tools remain uncertain. We argue that there is an urgent need for policy-makers, 
      regulators and professional societies to provide guidance on the most efficient
      and ethical manner for such tests to be introduced into clinical practice in the 
      USA.
FAU - Allyse, Megan
AU  - Allyse M
AD  - Stanford Center for Biomedical Ethics, Stanford, CA 94305-5417, USA.
      megand@stanford.edu
FAU - Sayres, Lauren C
AU  - Sayres LC
FAU - King, Jaime S
AU  - King JS
FAU - Norton, Mary E
AU  - Norton ME
FAU - Cho, Mildred K
AU  - Cho MK
LA  - eng
GR  - UL1 RR025744/RR/NCRR NIH HHS/United States
GR  - UL1 TR001085/TR/NCATS NIH HHS/United States
GR  - 1 U54 RR024374-01A1/RR/NCRR NIH HHS/United States
GR  - P50 HG003389/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20120803
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - *Aneuploidy
MH  - Cell-Free System
MH  - Chromosome Aberrations/*embryology
MH  - DNA/*genetics/isolation & purification
MH  - Decision Trees
MH  - Female
MH  - *Genetic Testing/trends
MH  - Humans
MH  - Practice Guidelines as Topic
MH  - Pregnancy
MH  - Prenatal Diagnosis/adverse effects/*methods
MH  - United States
PMC - PMC3472618
EDAT- 2012/08/07 06:00
MHDA- 2013/03/30 06:00
CRDT- 2012/08/07 06:00
PHST- 2012/08/07 06:00 [entrez]
PHST- 2012/08/07 06:00 [pubmed]
PHST- 2013/03/30 06:00 [medline]
AID - des286 [pii]
AID - 10.1093/humrep/des286 [doi]
PST - ppublish
SO  - Hum Reprod. 2012 Nov;27(11):3123-31. doi: 10.1093/humrep/des286. Epub 2012 Aug 3.


PMID- 22863021
OWN - NLM
STAT- MEDLINE
DCOM- 20121221
LR  - 20211021
IS  - 1471-2431 (Electronic)
IS  - 1471-2431 (Linking)
VI  - 12
DP  - 2012 Aug 3
TI  - A comparison of two treatments for childhood apraxia of speech: methods and
      treatment protocol for a parallel group randomised control trial.
PG  - 112
LID - 10.1186/1471-2431-12-112 [doi]
AB  - BACKGROUND: Childhood Apraxia of Speech is an impairment of speech motor planning
      that manifests as difficulty producing the sounds (articulation) and melody
      (prosody) of speech. These difficulties may persist through life and are
      detrimental to academic, social, and vocational development. A number of
      published single subject and case series studies of speech treatments are
      available. There are currently no randomised control trials or other well
      designed group trials available to guide clinical practice. METHODS/DESIGN: A
      parallel group, fixed size randomised control trial will be conducted in Sydney, 
      Australia to determine the efficacy of two treatments for Childhood Apraxia of
      Speech: 1) Rapid Syllable Transition Treatment and the 2) Nuffield Dyspraxia
      Programme - Third edition. Eligible children will be English speaking, aged 4-12 
      years with a diagnosis of suspected CAS, normal or adjusted hearing and vision,
      and no comprehension difficulties or other developmental diagnoses. At least 20
      children will be randomised to receive one of the two treatments in parallel.
      Treatments will be delivered by trained and supervised speech pathology
      clinicians using operationalised manuals. Treatment will be administered in
      1-hour sessions, 4 times per week for 3 weeks. The primary outcomes are speech
      sound and prosodic accuracy on a customised 292 item probe and the Diagnostic
      Evaluation of Articulation and Phonology inconsistency subtest administered prior
      to treatment and 1 week, 1 month and 4 months post-treatment. All post
      assessments will be completed by blinded assessors. Our hypotheses are: 1)
      treatment effects at 1 week post will be similar for both treatments, 2)
      maintenance of treatment effects at 1 and 4 months post will be greater for Rapid
      Syllable Transition Treatment than Nuffield Dyspraxia Programme treatment, and 3)
      generalisation of treatment effects to untrained related speech behaviours will
      be greater for Rapid Syllable Transition Treatment than Nuffield Dyspraxia
      Programme treatment. This protocol was approved by the Human Research Ethics
      Committee, University of Sydney (#12924). DISCUSSION: This will be the first
      randomised control trial to test treatment for CAS. It will be valuable for
      clinical decision-making and providing evidence-based services for children with 
      CAS. TRIAL REGISTRATION: Australian New Zealand Clinical Trials Registry:
      ACTRN12612000744853.
FAU - Murray, Elizabeth
AU  - Murray E
AD  - Speech Pathology, Faculty of Health Sciences, The University of Sydney, PO Box
      170, Lidcombe, 1825, Sydney, Australia. elizabeth.murray@sydney.edu.au
FAU - McCabe, Patricia
AU  - McCabe P
FAU - Ballard, Kirrie J
AU  - Ballard KJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20120803
PL  - England
TA  - BMC Pediatr
JT  - BMC pediatrics
JID - 100967804
SB  - IM
MH  - Analysis of Variance
MH  - Apraxias/*therapy
MH  - Child
MH  - Child, Preschool
MH  - Clinical Protocols
MH  - Humans
MH  - Speech Disorders/*therapy
MH  - Speech Therapy/*methods
MH  - Treatment Outcome
PMC - PMC3441276
EDAT- 2012/08/07 06:00
MHDA- 2012/12/22 06:00
CRDT- 2012/08/07 06:00
PHST- 2012/07/18 00:00 [received]
PHST- 2012/07/25 00:00 [accepted]
PHST- 2012/08/07 06:00 [entrez]
PHST- 2012/08/07 06:00 [pubmed]
PHST- 2012/12/22 06:00 [medline]
AID - 1471-2431-12-112 [pii]
AID - 10.1186/1471-2431-12-112 [doi]
PST - epublish
SO  - BMC Pediatr. 2012 Aug 3;12:112. doi: 10.1186/1471-2431-12-112.


PMID- 22862892
OWN - NLM
STAT- MEDLINE
DCOM- 20130610
LR  - 20220311
IS  - 1472-6831 (Electronic)
IS  - 1472-6831 (Linking)
VI  - 12
DP  - 2012 Aug 3
TI  - Oral healthcare of preschool children in Trinidad: a qualitative study of parents
      and caregivers.
PG  - 27
LID - 10.1186/1472-6831-12-27 [doi]
AB  - BACKGROUND: Little is known about oral health in early childhood in the West
      Indies or the views and experiences of caregivers about preventive oral care and 
      dental attendance The aims of this study were to explore and understand parents
      and caregivers' experience of oral healthcare for their preschool aged children
      and how, within their own social context, this may have shaped their oral health 
      attitudes and behaviours. These data can be used to inform oral health promotion 
      strategies for this age group. METHOD: After ethical approval, a qualitative
      study was undertaken using a focus group approach with a purposive sample of
      parents and caregivers of preschool children in central Trinidad.Group
      discussions were initiated by use of a topic guide. Audio recording and field
      notes from the three focus groups, with a total of 18 participants, were
      transcribed and analysed using a thematic approach. RESULTS: Despite some
      ambivalence toward the importance of the primary teeth, the role of fluoride and 
      confusion about when to take a child for their first dental visit, most
      participants understood the need to ensure good oral hygiene and dietary habits
      for their child. Problems expressed included, overcoming their own negative
      experiences of dentistry, which along with finding affordable and suitable dental
      clinics, affected their attitude to taking their child for a dental visit. There 
      was difficulty in establishing good brushing routines and controlling sweet
      snacking in the face of many other responsibilities at home. Lack of availability
      of paediatric dental services locally and information on oral health care were
      also highlighted. Many expressed a need for more contact with dental
      professionals in non-clinic settings, for oral health care advice and guidance.
      CONCLUSION: Parents and caregivers in this qualitative study showed generally
      positive attitudes towards oral health but appear to have encountered several
      barriers and challenges to achieving ideal preventive care for their child, with 
      respect to healthy diet, good oral hygiene and dental attendance. Oral health
      promotion should include effective dissemination of oral health information, more
      practical health advice and greater access to dental care for families with
      preschool children.
FAU - Naidu, Rahul
AU  - Naidu R
AD  - Community Dentistry, Faculty of Medical Sciences, The University of the West
      Indies, Port of Spain, Trinidad and Tobago. rsnaidu937@gmail.com
FAU - Nunn, June
AU  - Nunn J
FAU - Forde, Maarit
AU  - Forde M
LA  - eng
PT  - Journal Article
DEP - 20120803
PL  - England
TA  - BMC Oral Health
JT  - BMC oral health
JID - 101088684
RN  - Q80VPU408O (Fluorides)
SB  - IM
MH  - Adult
MH  - Bottle Feeding/adverse effects
MH  - Caregivers/psychology
MH  - Child Health Services
MH  - Child, Preschool
MH  - *Dental Anxiety
MH  - Dental Care for Children/*psychology/*statistics & numerical data
MH  - Dental Caries/etiology/prevention & control
MH  - Dental Health Services
MH  - Feeding Behavior
MH  - Female
MH  - Fluorides
MH  - Focus Groups
MH  - Health Education, Dental
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oral Hygiene/psychology
MH  - Parents/*psychology
MH  - Qualitative Research
MH  - Social Class
MH  - Tooth, Deciduous
MH  - Trinidad and Tobago
MH  - Young Adult
PMC - PMC3567990
EDAT- 2012/08/07 06:00
MHDA- 2013/06/12 06:00
CRDT- 2012/08/07 06:00
PHST- 2012/05/26 00:00 [received]
PHST- 2012/07/27 00:00 [accepted]
PHST- 2012/08/07 06:00 [entrez]
PHST- 2012/08/07 06:00 [pubmed]
PHST- 2013/06/12 06:00 [medline]
AID - 1472-6831-12-27 [pii]
AID - 10.1186/1472-6831-12-27 [doi]
PST - epublish
SO  - BMC Oral Health. 2012 Aug 3;12:27. doi: 10.1186/1472-6831-12-27.


PMID- 22862141
OWN - NLM
STAT- MEDLINE
DCOM- 20130408
LR  - 20151119
IS  - 1479-828X (Electronic)
IS  - 0004-8666 (Linking)
VI  - 52
IP  - 5
DP  - 2012 Oct
TI  - Post-mortem sperm retrieval in Australasia.
PG  - 487-90
LID - 10.1111/j.1479-828X.2012.01469.x [doi]
AB  - Post-mortem Sperm Retrieval (PMSR) is seldom requested in Australasia. The
      retrieval of sperm is permitted only by prior written consent or by order of the 
      court. Sperm should be retrieved within 24 h following death; however, collection
      within 36 h may still be successful. The clinical response to such a request must
      be mindful of complex ethical and legal considerations. Clear, accessible and
      consistent law in this area would benefit medical, legal and societal
      stakeholders.
CI  - (c) 2012 The Authors ANZJOG (c) 2012 The Royal Australian and New Zealand College
      of Obstetricians and Gynaecologists.
FAU - Kroon, Benjamin
AU  - Kroon B
AD  - Queensland Fertility Group Research Foundation, University of Queensland,
      Brisbane, QLD, Australia. bkroon@evehealth.com.au
FAU - Kroon, Frederick
AU  - Kroon F
FAU - Holt, Saul
AU  - Holt S
FAU - Wong, Brittany
AU  - Wong B
FAU - Yazdani, Anusch
AU  - Yazdani A
LA  - eng
PT  - Journal Article
DEP - 20120802
PL  - Australia
TA  - Aust N Z J Obstet Gynaecol
JT  - The Australian & New Zealand journal of obstetrics & gynaecology
JID - 0001027
SB  - IM
MH  - Advance Directives/ethics/legislation & jurisprudence
MH  - Australasia
MH  - Fertilization in Vitro/ethics/*legislation & jurisprudence
MH  - Humans
MH  - Male
MH  - Practice Guidelines as Topic
MH  - Sperm Retrieval/*ethics/*legislation & jurisprudence/standards
MH  - Surveys and Questionnaires
MH  - Third-Party Consent/ethics/legislation & jurisprudence
MH  - Time Factors
EDAT- 2012/08/07 06:00
MHDA- 2013/04/09 06:00
CRDT- 2012/08/07 06:00
PHST- 2011/12/18 00:00 [received]
PHST- 2012/06/23 00:00 [accepted]
PHST- 2012/08/07 06:00 [entrez]
PHST- 2012/08/07 06:00 [pubmed]
PHST- 2013/04/09 06:00 [medline]
AID - 10.1111/j.1479-828X.2012.01469.x [doi]
PST - ppublish
SO  - Aust N Z J Obstet Gynaecol. 2012 Oct;52(5):487-90. doi:
      10.1111/j.1479-828X.2012.01469.x. Epub 2012 Aug 2.


PMID- 22860778
OWN - NLM
STAT- MEDLINE
DCOM- 20121015
LR  - 20190902
IS  - 1326-5377 (Electronic)
IS  - 0025-729X (Linking)
VI  - 197
IP  - 3
DP  - 2012 Aug 6
TI  - The ethics of industry sponsorship of charities.
PG  - 139
FAU - Grills, Nathan J
AU  - Grills NJ
AD  - Nossal Institute of Global Health, University of Melbourne, Melbourne, VIC.
      nathangrills@gmail.com
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Med J Aust
JT  - The Medical journal of Australia
JID - 0400714
SB  - IM
MH  - Capital Financing/economics
MH  - Charities/economics/*ethics
MH  - Delivery of Health Care/economics/ethics
MH  - Industry/economics/*ethics
EDAT- 2012/08/07 06:00
MHDA- 2012/10/16 06:00
CRDT- 2012/08/07 06:00
PHST- 2012/08/07 06:00 [entrez]
PHST- 2012/08/07 06:00 [pubmed]
PHST- 2012/10/16 06:00 [medline]
AID - 10.5694/mja11.10929 [pii]
AID - 10.5694/mja11.10929 [doi]
PST - ppublish
SO  - Med J Aust. 2012 Aug 6;197(3):139. doi: 10.5694/mja11.10929.


PMID- 22860396
OWN - NLM
STAT- MEDLINE
DCOM- 20120830
LR  - 20120806
IS  - 0742-8367 (Print)
IS  - 0742-8367 (Linking)
VI  - 60
IP  - 3
DP  - 2012 Jul-Sep
TI  - Facilitating the transformation of information technology: strategies for nurse
      administrators.
PG  - 3-4
AB  - The effects of technology on the healthcare system have been multifaceted. While 
      the benefits clearly outweigh the negatives that come with technology, there are 
      various challenges that arise with technological implementation. The nurse
      administrator's role is to ensure that technological systems are transformed
      effectively and that financial, ethical, and legal implications are considered.
FAU - Ford, Jill
AU  - Ford J
AD  - Western Kentucky University, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ky Nurse
JT  - Kentucky nurse
JID - 8309653
MH  - Ethics, Nursing
MH  - Humans
MH  - *Nurse Administrators
MH  - Nurse's Role
MH  - Nursing Informatics/economics/legislation & jurisprudence/*organization &
      administration
MH  - Organizational Innovation
MH  - *Staff Development
MH  - United States
EDAT- 2012/08/07 06:00
MHDA- 2012/08/31 06:00
CRDT- 2012/08/07 06:00
PHST- 2012/08/07 06:00 [entrez]
PHST- 2012/08/07 06:00 [pubmed]
PHST- 2012/08/31 06:00 [medline]
PST - ppublish
SO  - Ky Nurse. 2012 Jul-Sep;60(3):3-4.


PMID- 22860343
OWN - NLM
STAT- MEDLINE
DCOM- 20120823
LR  - 20190719
IS  - 0029-6570 (Print)
IS  - 0029-6570 (Linking)
VI  - 26
IP  - 43
DP  - 2012 Jun 27-Jul 3
TI  - Giving the gift of life.
PG  - 24-5
AB  - Living donation is the'Rolls-Royce' option for kidney patients, with few risks
      for donors. However, donating lung and liver tissue carries greater risks. Here, 
      nurses involved in organ transplants consider the practical and ethical issues of
      the growing practice of living donation.
FAU - Trueland, Jennifer
AU  - Trueland J
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Stand
JT  - Nursing standard (Royal College of Nursing (Great Britain) : 1987)
JID - 9012906
MH  - *Altruism
MH  - Humans
MH  - Kidney Transplantation/ethics/*psychology/statistics & numerical data
MH  - Liver Transplantation
MH  - *Living Donors/ethics/statistics & numerical data
MH  - Lung Transplantation
EDAT- 2012/08/07 06:00
MHDA- 2012/08/24 06:00
CRDT- 2012/08/07 06:00
PHST- 2012/08/07 06:00 [entrez]
PHST- 2012/08/07 06:00 [pubmed]
PHST- 2012/08/24 06:00 [medline]
AID - 10.7748/ns.26.43.24.s29 [doi]
PST - ppublish
SO  - Nurs Stand. 2012 Jun 27-Jul 3;26(43):24-5. doi: 10.7748/ns.26.43.24.s29.


PMID- 22859828
OWN - NLM
STAT- MEDLINE
DCOM- 20121129
LR  - 20220321
IS  - 1465-3621 (Electronic)
IS  - 0368-2811 (Linking)
VI  - 42
IP  - 10
DP  - 2012 Oct
TI  - Association of coping style, cognitive errors and cancer-related variables with
      depression in women treated for breast cancer.
PG  - 940-7
AB  - OBJECTIVE: The purpose of this study was to examine the correlation between
      depression levels with coping styles and cognitive errors in women treated for
      breast cancer. METHODS: A total of 110 breast cancer outpatients who had had
      surgery at least 6 months previously, had completed adjuvant cancer treatment and
      had not experienced metastasis or recurrent lesions were evaluated. The Automatic
      Thoughts Questionnaire, Cognitive Errors Questionnaire, Mental Adjustment to
      Cancer Scale and Beck Depression Inventory were administered to all patients.
      Semi-structured interview forms were used to obtain medical and demographic data.
      All patients were categorized into depression and non-depression groups according
      to their Beck Depression Inventory scores. The study protocol was approved by the
      Medical Ethics Committee of Istanbul University Oncology Institute. RESULTS:
      Higher cognitive errors and automatic thought scores were found in the depression
      group. Fighting spirit was found to be the primary coping style used in the
      non-depression group, while helplessness/hopelessness, anxious/preoccupation and 
      fatalism were the coping styles used the most in the depression group. No
      association between depression and socio-demographic (except for educational
      level) and cancer-related variables was detected. However, it was found that
      automatic thoughts, cognitive errors, education level, fighting spirit and
      anxious/preoccupation are important indicators of depression in our sample.
      CONCLUSIONS: A causal relationship exists between depression and a patient's
      cognitive patterns and accompanying anxiety. The degree of depression is
      inversely related to both fighting spirit coping type and educational level. If
      clinicians take this into consideration, diagnosing and treating depression will 
      be more effective.
FAU - Alcalar, Nilufer
AU  - Alcalar N
AD  - Department of Consultation Liaison Psychiatry, Istanbul Medical School, Istanbul 
      University, Capa-Istanbul, Turkey. nilalcalar@yahoo.com
FAU - Ozkan, Sedat
AU  - Ozkan S
FAU - Kucucuk, Seden
AU  - Kucucuk S
FAU - Aslay, Isik
AU  - Aslay I
FAU - Ozkan, Mine
AU  - Ozkan M
LA  - eng
PT  - Journal Article
DEP - 20120731
PL  - England
TA  - Jpn J Clin Oncol
JT  - Japanese journal of clinical oncology
JID - 0313225
SB  - IM
MH  - *Adaptation, Psychological
MH  - Adult
MH  - Aged
MH  - Breast Neoplasms/*complications/*psychology/surgery
MH  - Cognition Disorders/*etiology
MH  - Cross-Sectional Studies
MH  - Depression/*etiology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Middle Aged
MH  - Prognosis
MH  - Risk Factors
MH  - Surveys and Questionnaires
EDAT- 2012/08/04 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/08/04 06:00
PHST- 2012/08/04 06:00 [entrez]
PHST- 2012/08/04 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - hys119 [pii]
AID - 10.1093/jjco/hys119 [doi]
PST - ppublish
SO  - Jpn J Clin Oncol. 2012 Oct;42(10):940-7. doi: 10.1093/jjco/hys119. Epub 2012 Jul 
      31.


PMID- 22859644
OWN - NLM
STAT- MEDLINE
DCOM- 20130523
LR  - 20211021
IS  - 1527-974X (Electronic)
IS  - 1067-5027 (Linking)
VI  - 20
IP  - 1
DP  - 2013 Jan 1
TI  - Privacy protection and public goods: building a genetic database for health
      research in Newfoundland and Labrador.
PG  - 38-43
LID - 10.1136/amiajnl-2012-001009 [doi]
AB  - OBJECTIVE: To provide a legal and ethical analysis of some of the implementation 
      challenges faced by the Population Therapeutics Research Group (PTRG) at Memorial
      University (Canada), in using genealogical information offered by individuals for
      its genetics research database. MATERIALS AND METHODS: This paper describes the
      unique historical and genetic characteristics of the Newfoundland and Labrador
      founder population, which gave rise to the opportunity for PTRG to build the
      Newfoundland Genealogy Database containing digitized records of all
      pre-confederation (1949) census records of the Newfoundland founder population.
      In addition to building the database, PTRG has developed the Heritability
      Analytics Infrastructure, a data management structure that stores genotype,
      phenotype, and pedigree information in a single database, and custom linkage
      software (KINNECT) to perform pedigree linkages on the genealogy database.
      DISCUSSION: A newly adopted legal regimen in Newfoundland and Labrador is
      discussed. It incorporates health privacy legislation with a unique research
      ethics statute governing the composition and activities of research ethics boards
      and, for the first time in Canada, elevating the status of national research
      ethics guidelines into law. The discussion looks at this integration of legal and
      ethical principles which provides a flexible and seamless framework for balancing
      the privacy rights and welfare interests of individuals, families, and larger
      societies in the creation and use of research data infrastructures as public
      goods. CONCLUSION: The complementary legal and ethical frameworks that now
      coexist in Newfoundland and Labrador provide the legislative authority, ethical
      legitimacy, and practical flexibility needed to find a workable balance between
      privacy interests and public goods. Such an approach may also be instructive for 
      other jurisdictions as they seek to construct and use biobanks and related
      research platforms for genetic research.
FAU - Kosseim, Patricia
AU  - Kosseim P
AD  - Office of the Privacy Commissioner of Canada, Ottawa, Ontario, Canada.
      patricia.kosseim@priv.gc.ca
FAU - Pullman, Daryl
AU  - Pullman D
FAU - Perrot-Daley, Astrid
AU  - Perrot-Daley A
FAU - Hodgkinson, Kathy
AU  - Hodgkinson K
FAU - Street, Catherine
AU  - Street C
FAU - Rahman, Proton
AU  - Rahman P
LA  - eng
PT  - Journal Article
DEP - 20120802
PL  - England
TA  - J Am Med Inform Assoc
JT  - Journal of the American Medical Informatics Association : JAMIA
JID - 9430800
SB  - IM
MH  - *Databases, Genetic/ethics/legislation & jurisprudence
MH  - *Genetic Privacy/ethics/legislation & jurisprudence
MH  - *Genetic Research/ethics/legislation & jurisprudence
MH  - Humans
MH  - Newfoundland and Labrador
MH  - *Pedigree
MH  - Program Development
PMC - PMC3555321
EDAT- 2012/08/04 06:00
MHDA- 2013/05/25 06:00
CRDT- 2012/08/04 06:00
PHST- 2012/08/04 06:00 [entrez]
PHST- 2012/08/04 06:00 [pubmed]
PHST- 2013/05/25 06:00 [medline]
AID - amiajnl-2012-001009 [pii]
AID - 10.1136/amiajnl-2012-001009 [doi]
PST - ppublish
SO  - J Am Med Inform Assoc. 2013 Jan 1;20(1):38-43. doi: 10.1136/amiajnl-2012-001009. 
      Epub 2012 Aug 2.


PMID- 22859561
OWN - NLM
STAT- MEDLINE
DCOM- 20130305
LR  - 20211021
IS  - 1744-957X (Electronic)
IS  - 1744-9561 (Linking)
VI  - 8
IP  - 6
DP  - 2012 Dec 23
TI  - Pro-sociality without empathy.
PG  - 910-2
LID - 10.1098/rsbl.2012.0554 [doi]
AB  - Empathy, the capacity to recognize and share feelings experienced by another
      individual, is an important trait in humans, but is not the same as
      pro-sociality, the tendency to behave so as to benefit another individual. Given 
      the importance of understanding empathy's evolutionary emergence, it is
      unsurprising that many studies attempt to find evidence for it in other species. 
      To address the question of what should constitute evidence for empathy, we offer 
      a critical comparison of two recent studies of rescuing behaviour that report
      similar phenomena but are interpreted very differently by their authors. In one
      of the studies, rescue behaviour in rats was interpreted as providing evidence
      for empathy, whereas in the other, rescue behaviour in ants was interpreted
      without reference to sharing of emotions. Evidence for empathy requires showing
      that actor individuals possess a representation of the receiver's emotional state
      and are driven by the psychological goal of improving its wellbeing. Proving
      psychological goal-directedness by current standards involves goal-devaluation
      and causal sensitivity protocols, which, in our view, have not been implemented
      in available publications. Empathy has profound significance not only for
      cognitive and behavioural sciences but also for philosophy and ethics and, in our
      view, remains unproven outside humans.
FAU - Vasconcelos, Marco
AU  - Vasconcelos M
AD  - School of Psychology, University of Minho, Campus de Gualtar, 4710-057 Braga,
      Portugal.
FAU - Hollis, Karen
AU  - Hollis K
FAU - Nowbahari, Elise
AU  - Nowbahari E
FAU - Kacelnik, Alex
AU  - Kacelnik A
LA  - eng
GR  - BB/G007144/1/BB_/Biotechnology and Biological Sciences Research Council/United
      Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120801
PL  - England
TA  - Biol Lett
JT  - Biology letters
JID - 101247722
SB  - IM
MH  - Animals
MH  - Ants
MH  - Behavior, Animal/*physiology
MH  - *Biological Evolution
MH  - *Empathy
MH  - Goals
MH  - Psychology
MH  - Rats
MH  - *Social Behavior
PMC - PMC3497120
EDAT- 2012/08/04 06:00
MHDA- 2013/03/06 06:00
CRDT- 2012/08/04 06:00
PHST- 2012/08/04 06:00 [entrez]
PHST- 2012/08/04 06:00 [pubmed]
PHST- 2013/03/06 06:00 [medline]
AID - rsbl.2012.0554 [pii]
AID - 10.1098/rsbl.2012.0554 [doi]
PST - ppublish
SO  - Biol Lett. 2012 Dec 23;8(6):910-2. doi: 10.1098/rsbl.2012.0554. Epub 2012 Aug 1.


PMID- 22859472
OWN - NLM
STAT- MEDLINE
DCOM- 20120914
LR  - 20211021
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Linking)
VI  - 337
IP  - 6094
DP  - 2012 Aug 3
TI  - Research ethics. Aligning regulations and ethics in human research.
PG  - 527-8
LID - 10.1126/science.1218323 [doi]
FAU - Dresser, Rebecca
AU  - Dresser R
AD  - School of Law, Washington University, St. Louis, MO 63130, USA.
      dresser@wulaw.wustl.edu
LA  - eng
GR  - UL1 RR024992/RR/NCRR NIH HHS/United States
GR  - UL1 TR000448/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
SB  - IM
MH  - Consent Forms/*standards
MH  - *Guidelines as Topic
MH  - Human Experimentation/*ethics/*statistics & numerical data
MH  - Humans
MH  - Informed Consent/*ethics/*standards
MH  - United States
MH  - United States Government Agencies
PMC - PMC3612933
MID - NIHMS447686
EDAT- 2012/08/04 06:00
MHDA- 2012/09/15 06:00
CRDT- 2012/08/04 06:00
PHST- 2012/08/04 06:00 [entrez]
PHST- 2012/08/04 06:00 [pubmed]
PHST- 2012/09/15 06:00 [medline]
AID - 337/6094/527 [pii]
AID - 10.1126/science.1218323 [doi]
PST - ppublish
SO  - Science. 2012 Aug 3;337(6094):527-8. doi: 10.1126/science.1218323.


PMID- 22859230
OWN - NLM
STAT- MEDLINE
DCOM- 20130521
LR  - 20120803
IS  - 1545-9616 (Print)
IS  - 1545-9616 (Linking)
VI  - 11
IP  - 8
DP  - 2012 Aug
TI  - Blunt-tipped microcannulas for filler injection: an ethical duty?
PG  - s42
FAU - Cassuto, Daniel
AU  - Cassuto D
LA  - eng
PT  - Editorial
PL  - United States
TA  - J Drugs Dermatol
JT  - Journal of drugs in dermatology : JDD
JID - 101160020
RN  - 0 (Biocompatible Materials)
SB  - IM
MH  - Biocompatible Materials/*administration & dosage
MH  - Catheters
MH  - Clinical Competence
MH  - Cosmetic Techniques/*ethics/*instrumentation
MH  - Humans
EDAT- 2012/08/04 06:00
MHDA- 2013/05/23 06:00
CRDT- 2012/08/04 06:00
PHST- 2012/08/04 06:00 [entrez]
PHST- 2012/08/04 06:00 [pubmed]
PHST- 2013/05/23 06:00 [medline]
PST - ppublish
SO  - J Drugs Dermatol. 2012 Aug;11(8):s42.


PMID- 22858821
OWN - NLM
STAT- MEDLINE
DCOM- 20121231
LR  - 20190608
IS  - 1680-5348 (Electronic)
IS  - 1020-4989 (Linking)
VI  - 31
IP  - 6
DP  - 2012 Jun
TI  - Biobanking for health research in Brazil: present challenges and future
      directions.
PG  - 523-8
LID - S1020-49892012000600012 [pii]
AB  - This article outlines and discusses Brazil's new regulations on the use of human 
      biological materials for research, specifically, Resolution CNS 441/11, enacted
      by the National Health Council of Brazil in May 2011, and the National Guidelines
      for Biorepositories and Biobanks (Ordinance No. 2201) published by the Ministry
      of Health in September 2011. The authors examine the differences between sample
      collections for single studies and large-scale collections for multiple studies
      (e.g., the National Tumor Bank at the Brazilian National Cancer Institute and the
      A. C. Camargo Hospital Biobank). Also discussed are the ethical and operational
      implications, i.e.,informed consent process, strategies for sample collection,
      custodianship, access to samples, and rules for disposal. Insights gained may be 
      useful for developing national biobanking regulations in other countries in Latin
      America.
FAU - Marodin, Gabriela
AU  - Marodin G
AD  - Brazilian Research Ethics Commission, Ministry of Health, Brasilia, Brazil.
FAU - Franca, Paulo
AU  - Franca P
FAU - Rocha, Jose Claudio Casali da
AU  - Rocha JC
FAU - Campos, Antonio Hugo
AU  - Campos AH
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Rev Panam Salud Publica
JT  - Revista panamericana de salud publica = Pan American journal of public health
JID - 9705400
SB  - IM
MH  - Biological Specimen Banks/ethics/*legislation & jurisprudence/*trends
MH  - Biomedical Research/*legislation & jurisprudence/*trends
MH  - Brazil
MH  - Forecasting
MH  - Humans
EDAT- 2012/08/04 06:00
MHDA- 2013/01/01 06:00
CRDT- 2012/08/04 06:00
PHST- 2011/07/08 00:00 [received]
PHST- 2012/02/06 00:00 [accepted]
PHST- 2012/08/04 06:00 [entrez]
PHST- 2012/08/04 06:00 [pubmed]
PHST- 2013/01/01 06:00 [medline]
AID - S1020-49892012000600012 [pii]
AID - 10.1590/s1020-49892012000600012 [doi]
PST - ppublish
SO  - Rev Panam Salud Publica. 2012 Jun;31(6):523-8. doi:
      10.1590/s1020-49892012000600012.


PMID- 22858719
OWN - NLM
STAT- MEDLINE
DCOM- 20130612
LR  - 20220316
IS  - 1530-0366 (Electronic)
IS  - 1098-3600 (Linking)
VI  - 15
IP  - 1
DP  - 2013 Jan
TI  - Regions of homozygosity identified by SNP microarray analysis aid in the
      diagnosis of autosomal recessive disease and incidentally detect parental blood
      relationships.
PG  - 70-8
LID - 10.1038/gim.2012.94 [doi]
AB  - PURPOSE: The purpose of this study was to document the ability of
      single-nucleotide polymorphism microarray to identify copy-neutral regions of
      homozygosity, demonstrate clinical utility of regions of homozygosity, and
      discuss ethical/legal implications when regions of homozygosity are associated
      with a parental blood relationship. METHODS: Study data were compiled from
      consecutive samples sent to our clinical laboratory over a 3-year period. A
      cytogenetics database identified patients with at least two regions of
      homozygosity >10 Mb on two separate chromosomes. A chart review was conducted on 
      patients who met the criteria. RESULTS: Of 3,217 single-nucleotide polymorphism
      microarrays, 59 (1.8%) patients met inclusion criteria. The percentage of
      homozygosity ranged from 0.9 to 30.1%, indicating parental relationships from
      distant to first-degree relatives. First-degree kinship was suspected in the
      parents of at least 11 patients with regions of homozygosity covering >21.3% of
      their autosome. In four patients from two families, homozygosity mapping
      discovered a candidate gene that was sequenced to identify a clinically
      significant mutation. CONCLUSION: This study demonstrates clinical utility in the
      identification of regions of homozygosity, as these regions may aid in diagnosis 
      of the patient. This study establishes the need for careful reporting, thorough
      pretest counseling, and careful electronic documentation, as microarray has the
      capability of detecting previously unknown/unreported relationships.
FAU - Sund, Kristen Lipscomb
AU  - Sund KL
AD  - Division of Human Genetics, Department of Pediatrics, Cincinnati Children's
      Hospital Medical Center, Cincinnati, Ohio, USA. Kristen.Sund@cchmc.org
FAU - Zimmerman, Sarah L
AU  - Zimmerman SL
FAU - Thomas, Cameron
AU  - Thomas C
FAU - Mitchell, Anna L
AU  - Mitchell AL
FAU - Prada, Carlos E
AU  - Prada CE
FAU - Grote, Lauren
AU  - Grote L
FAU - Bao, Liming
AU  - Bao L
FAU - Martin, Lisa J
AU  - Martin LJ
FAU - Smolarek, Teresa A
AU  - Smolarek TA
LA  - eng
GR  - UL1 TR000077/TR/NCATS NIH HHS/United States
PT  - Journal Article
DEP - 20120802
PL  - United States
TA  - Genet Med
JT  - Genetics in medicine : official journal of the American College of Medical
      Genetics
JID - 9815831
SB  - IM
MH  - *Chromosome Mapping
MH  - Chromosomes, Human, X
MH  - Consanguinity
MH  - Female
MH  - *Genes, Recessive
MH  - Genetic Diseases, Inborn/*diagnosis
MH  - *Homozygote
MH  - Humans
MH  - Male
MH  - Medical Records
MH  - Oligonucleotide Array Sequence Analysis
MH  - *Pedigree
MH  - *Polymorphism, Single Nucleotide
MH  - Siblings
EDAT- 2012/08/04 06:00
MHDA- 2013/06/13 06:00
CRDT- 2012/08/04 06:00
PHST- 2012/08/04 06:00 [entrez]
PHST- 2012/08/04 06:00 [pubmed]
PHST- 2013/06/13 06:00 [medline]
AID - S1098-3600(21)02363-7 [pii]
AID - 10.1038/gim.2012.94 [doi]
PST - ppublish
SO  - Genet Med. 2013 Jan;15(1):70-8. doi: 10.1038/gim.2012.94. Epub 2012 Aug 2.


PMID- 22857777
OWN - NLM
STAT- MEDLINE
DCOM- 20130104
LR  - 20211021
IS  - 1873-5134 (Electronic)
IS  - 0738-3991 (Linking)
VI  - 89
IP  - 1
DP  - 2012 Oct
TI  - Medical interpreters as tools: dangers and challenges in the utilitarian approach
      to interpreters' roles and functions.
PG  - 158-62
LID - 10.1016/j.pec.2012.07.001 [doi]
LID - S0738-3991(12)00265-0 [pii]
AB  - OBJECTIVE: This study explores the tensions, challenges, and dangers when a
      utilitarian view of interpreter is constructed, imposed, and/or reinforced in
      health care settings. METHODS: We conducted in-depth interviews and focus groups 
      with 26 medical interpreters from 17 different languages and cultures and 39
      providers of five specialties. Grounded theory was used for data analysis.
      RESULTS: The utilitarian view to interpreters' roles and functions influences
      providers in the following areas: (a) hierarchical structure and unidirectional
      communication, (b) the interpreter seen as information gatekeeper, (c) the
      interpreter seen as provider proxy, and (d) interpreter's emotional support
      perceived as tools. CONCLUSION: When interpreters are viewed as passive
      instruments, a utilitarian approach may compromise the quality of care by
      silencing patients' and interpreters' voice, objectifying interpreters' emotional
      work, and exploiting patients' needs. PRACTICE IMPLICATIONS: Providers need to
      recognize that a utilitarian approach to the interpreter's role and functions may
      create interpersonal and ethical dilemmas that compromise the quality of care. By
      viewing interpreters as smart technology (rather than passive instruments), both 
      providers and interpreters can learn from and co-evolve with each other, allowing
      them to maintain control over their expertise and to work as collaborators in
      providing quality care.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Hsieh, Elaine
AU  - Hsieh E
AD  - Department of Communication, University of Oklahoma, Norman, USA. ehsieh@ou.edu
FAU - Kramer, Eric Mark
AU  - Kramer EM
LA  - eng
GR  - R03 MH076205/MH/NIMH NIH HHS/United States
GR  - #1R03MH76205-01-A1/MH/NIMH NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20120731
PL  - Ireland
TA  - Patient Educ Couns
JT  - Patient education and counseling
JID - 8406280
MH  - Adult
MH  - *Allied Health Personnel
MH  - *Attitude of Health Personnel
MH  - Communication
MH  - Communication Barriers
MH  - Delivery of Health Care
MH  - Ethical Theory
MH  - Female
MH  - Focus Groups
MH  - *Health Communication
MH  - Humans
MH  - *Interprofessional Relations
MH  - Interviews as Topic
MH  - Male
MH  - Middle Aged
MH  - Multilingualism
MH  - Physician-Patient Relations
MH  - *Professional Role
MH  - Professional-Patient Relations
MH  - *Translating
MH  - United States
PMC - PMC3462307
MID - NIHMS393912
EDAT- 2012/08/04 06:00
MHDA- 2013/01/05 06:00
CRDT- 2012/08/04 06:00
PHST- 2011/11/29 00:00 [received]
PHST- 2012/06/17 00:00 [revised]
PHST- 2012/07/01 00:00 [accepted]
PHST- 2012/08/04 06:00 [entrez]
PHST- 2012/08/04 06:00 [pubmed]
PHST- 2013/01/05 06:00 [medline]
AID - S0738-3991(12)00265-0 [pii]
AID - 10.1016/j.pec.2012.07.001 [doi]
PST - ppublish
SO  - Patient Educ Couns. 2012 Oct;89(1):158-62. doi: 10.1016/j.pec.2012.07.001. Epub
      2012 Jul 31.


PMID- 22857731
OWN - NLM
STAT- MEDLINE
DCOM- 20121002
LR  - 20161125
IS  - 1865-9217 (Print)
IS  - 1865-9217 (Linking)
VI  - 106
IP  - 6
DP  - 2012
TI  - [National and regional prioritisation in Swedish health care: experiences from
      cardiology].
PG  - 435-42
LID - 10.1016/j.zefq.2012.06.002 [doi]
AB  - Prioritisation of medical services in Sweden takes place on two different levels.
      On the national level, the Swedish priority guidelines ascribe priority values
      ranging from 1 (high priority) to 10 (low priority) to measures (in terms of
      condition-treatment pairs) of prevention, diagnosis, treatment and rehabilitation
      of cardiovascular diseases. In addition, this list contains interventions that
      should be avoided and those that should only be provided as part of clinical
      research projects. The government then commissions a multi-professional team
      under the supervision of the National Board of Health and Welfare
      "Socialstyelsen" with the development of corresponding guidelines. In addition to
      the scientific evidence, the priority lists incorporate ethical and economical
      aspects and are based on the so-called ethics platform consisting of human
      dignity, needs, solidarity and cost-effectiveness. At the other level of
      prioritisation there are regional projects aiming at the in- and exclusion of
      medical measures. The Swedish prioritisation process will be described using the 
      example of priority lists in cardiology. (As supplied by publisher).
CI  - Copyright (c) 2012. Published by Elsevier GmbH.
FAU - Carlsson, Jorg
AU  - Carlsson J
AD  - Linnaeus University and Medicinska kliniken, Lanssjukhuset i Kalmar, Schweden.
      jorg.carlsson@ltkalmar.se
LA  - ger
PT  - Comparative Study
PT  - Journal Article
TT  - Nationale und regionale Priorisierung im schwedischen Gesundheitswesen:
      Erfahrungen aus der Kardiologie.
DEP - 20120627
PL  - Netherlands
TA  - Z Evid Fortbild Qual Gesundhwes
JT  - Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen
JID - 101477604
SB  - IM
MH  - *Cardiac Rehabilitation
MH  - Cardiovascular Diseases/economics
MH  - Cost Savings/economics
MH  - Cost-Benefit Analysis/economics/organization & administration
MH  - *Cross-Cultural Comparison
MH  - Evidence-Based Medicine/economics/organization & administration
MH  - Guideline Adherence/economics/organization & administration
MH  - Health Care Rationing/economics/*organization & administration
MH  - Health Priorities/economics/*organization & administration
MH  - Health Services Needs and Demand/organization & administration
MH  - Humans
MH  - National Health Programs/economics/*organization & administration
MH  - Regional Health Planning/economics/*organization & administration
MH  - Sweden
EDAT- 2012/08/04 06:00
MHDA- 2012/10/04 06:00
CRDT- 2012/08/04 06:00
PHST- 2012/08/04 06:00 [entrez]
PHST- 2012/08/04 06:00 [pubmed]
PHST- 2012/10/04 06:00 [medline]
AID - S1865-9217(12)00151-1 [pii]
AID - 10.1016/j.zefq.2012.06.002 [doi]
PST - ppublish
SO  - Z Evid Fortbild Qual Gesundhwes. 2012;106(6):435-42. doi:
      10.1016/j.zefq.2012.06.002. Epub 2012 Jun 27.


PMID- 22857724
OWN - NLM
STAT- MEDLINE
DCOM- 20121002
LR  - 20161125
IS  - 1865-9217 (Print)
IS  - 1865-9217 (Linking)
VI  - 106
IP  - 6
DP  - 2012
TI  - [The national public discourse on priority setting in health care in German print
      media].
PG  - 389-96
LID - 10.1016/j.zefq.2012.06.007 [doi]
AB  - Germany's Central Ethics Committee of the Federal Chamber of Physicians (FCP) and
      other relevant national actors called for a public discourse on priority setting 
      in health care. Politicians, members of a Federal Joint Committee and health
      insurance representatives, however, refused to promote or participate in the
      establishment of a public discussion. A change to that attitude only became
      apparent after former FCP President Hoppe's opening speech at the annual FCP
      assembly in Mainz in 2009. The present paper applies the Sociology of Knowledge
      Approach to Discourse, implemented through Qualitative Content Analysis and
      elements of Grounded Theory, to examine the development of the national public
      discourse in leading German print media. It creates a matrix that represents the 
      discourse development between May 2009 and May 2010 and reflects central actors, 
      their "communicative phenomena" and their interactions. Additionally, the matrix 
      has been extended to cover the period until December 2011. Hoppe's arguments for 
      priority setting in health care are faced with a wide opposition assuming
      opposing prerequisites and thus demanding alternative remedies. The lack of
      interaction between the different parties prevents any development of the
      speakers' positions. Incorrect accounts, reductions and left-outs in the media
      representation add to this effect. Consequently, the public discussion on
      priority setting is far from being an evolving rational discourse. Instead, it
      constitutes an exchange of preformed opposing positions.
CI  - Copyright (c) 2012. Published by Elsevier GmbH.
FAU - Liesching, Florian
AU  - Liesching F
AD  - Seniorprofessur fur Bevolkerungsmedizin, Akademisches Zentrum fur
      Bevolkerungsmedizin und Versorgungsforschung, Universitat zu Lubeck.
      Florian.Liesching@medizin.uni-luebeck.de
FAU - Meyer, Thorsten
AU  - Meyer T
FAU - Raspe, Heiner
AU  - Raspe H
LA  - ger
PT  - Journal Article
TT  - Eine Analyse des nationalen offentlichen Priorisierungsdiskurses in deutschen
      Printmedien.
DEP - 20120628
PL  - Netherlands
TA  - Z Evid Fortbild Qual Gesundhwes
JT  - Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen
JID - 101477604
SB  - IM
MH  - Community Participation
MH  - Cost Savings/ethics/trends
MH  - Ethics, Medical
MH  - Evidence-Based Medicine/economics/trends
MH  - Forecasting
MH  - Germany
MH  - Health Care Rationing/economics/ethics/trends
MH  - Health Priorities/economics/ethics/*trends
MH  - Health Services Accessibility/economics/ethics/trends
MH  - Humans
MH  - National Health Programs/economics/ethics/*trends
MH  - Newspapers as Topic
MH  - Politics
MH  - *Public Opinion
EDAT- 2012/08/04 06:00
MHDA- 2012/10/04 06:00
CRDT- 2012/08/04 06:00
PHST- 2012/08/04 06:00 [entrez]
PHST- 2012/08/04 06:00 [pubmed]
PHST- 2012/10/04 06:00 [medline]
AID - S1865-9217(12)00156-0 [pii]
AID - 10.1016/j.zefq.2012.06.007 [doi]
PST - ppublish
SO  - Z Evid Fortbild Qual Gesundhwes. 2012;106(6):389-96. doi:
      10.1016/j.zefq.2012.06.007. Epub 2012 Jun 28.


PMID- 22857602
OWN - NLM
STAT- MEDLINE
DCOM- 20131125
LR  - 20220409
IS  - 1475-2727 (Electronic)
IS  - 1368-9800 (Linking)
VI  - 16
IP  - 5
DP  - 2013 May
TI  - Socio-economic disparities in the consumption of vegetables, fruit and
      energy-dense foods: the role of motive priorities.
PG  - 873-82
LID - 10.1017/S1368980012003540 [doi]
AB  - OBJECTIVE: A low socio-economic status (SES) is related to less healthy dietary
      habits, but the reasons for this remain unclear. We examined whether the absolute
      or relative importance of various food choice motives contributed to SES
      disparities in vegetable/fruit and energy-dense food intake. DESIGN: We analysed 
      cross-sectional data from the FINRISK Study 2007 by means of structural equation 
      modelling and used a shortened version of the Food Choice Questionnaire to assess
      the absolute importance of health, pleasure, convenience, price, familiarity and 
      ethicality motives. We calculated the relative importance of each motive by
      dividing the participant's rating of it by his/her mean score on all motives.
      Dietary intake was measured with an FFQ. SETTING: A population-based survey in
      Finland. SUBJECTS: Men (n 1691) and women (n 2059) aged 25-64 years. RESULTS:
      Higher education and income were related to a greater vegetable/fruit intake
      (beta = 0.12, P < 0.001), while education was associated negatively with the
      consumption of energy-dense foods (beta = -0.09, P < 0.001). Socio-economically
      disadvantaged individuals considered price and/or familiarity more important in
      their food choices in both absolute and relative terms. A higher income was
      related to a greater relative importance of health considerations. Relative
      motives were more strongly associated with vegetable/fruit and energy-dense food 
      consumption than absolute motives and the relative importance of price,
      familiarity and health partly mediated the effects of the SES indicators on the
      consumption of these food items. CONCLUSIONS: Individual priorities in food
      choice motives, rather than the absolute importance of single motives, play a
      role in producing SES disparities in diet.
FAU - Konttinen, Hanna
AU  - Konttinen H
AD  - Department of Social Research, University of Helsinki, University of Helsinki,
      Helsinki, Finland. hanna.konttinen@helsinki.fi
FAU - Sarlio-Lahteenkorva, Sirpa
AU  - Sarlio-Lahteenkorva S
FAU - Silventoinen, Karri
AU  - Silventoinen K
FAU - Mannisto, Satu
AU  - Mannisto S
FAU - Haukkala, Ari
AU  - Haukkala A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120803
PL  - England
TA  - Public Health Nutr
JT  - Public health nutrition
JID - 9808463
SB  - IM
MH  - Adult
MH  - Choice Behavior
MH  - Cross-Sectional Studies
MH  - Diet/*economics
MH  - *Feeding Behavior
MH  - Female
MH  - Finland
MH  - Food Preferences
MH  - Fruit/*economics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Motivation
MH  - Nutrition Surveys
MH  - Socioeconomic Factors
MH  - Surveys and Questionnaires
MH  - Vegetables/*economics
EDAT- 2012/08/04 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/08/04 06:00
PHST- 2012/08/04 06:00 [entrez]
PHST- 2012/08/04 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - S1368980012003540 [pii]
AID - 10.1017/S1368980012003540 [doi]
PST - ppublish
SO  - Public Health Nutr. 2013 May;16(5):873-82. doi: 10.1017/S1368980012003540. Epub
      2012 Aug 3.


PMID- 22856360
OWN - NLM
STAT- MEDLINE
DCOM- 20131213
LR  - 20120803
IS  - 1832-4274 (Print)
IS  - 1832-4274 (Linking)
VI  - 15
IP  - 2
DP  - 2012 Apr
TI  - Organ donation: a twin-based perspective.
PG  - 262-6
LID - 10.1375/twin.15.2.262 [doi]
AB  - Monozygotic cotwins are ideal organ donors for one another due to their genetic
      identity. The present report treats this topic differently, from the perspective 
      of a monozygotic twin who donated her deceased twin sister's organs following her
      sister's untimely death. This discussion is followed by reviews of recent
      research concerning increased twinning rates in the United States, availability
      of informative kinship pedigrees, and twin discordance for physical activities.
      Noteworthy news items include ethical issues surrounding conjoined twin
      separation, a genomic discovery for diseased twins, China's One-Child Policy, a
      striking New Yorker Magazine cartoon, and twin delivery complications.
FAU - Segal, Nancy L
AU  - Segal NL
AD  - Department of Psychology, California State University, United States of America.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Twin Res Hum Genet
JT  - Twin research and human genetics : the official journal of the International
      Society for Twin Studies
JID - 101244624
SB  - IM
MH  - Female
MH  - Humans
MH  - Male
MH  - *Tissue and Organ Procurement
MH  - Twin Studies as Topic
MH  - *Twins, Monozygotic
EDAT- 2012/08/04 06:00
MHDA- 2013/12/18 06:00
CRDT- 2012/08/04 06:00
PHST- 2012/08/04 06:00 [entrez]
PHST- 2012/08/04 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
AID - S1832427400012020 [pii]
AID - 10.1375/twin.15.2.262 [doi]
PST - ppublish
SO  - Twin Res Hum Genet. 2012 Apr;15(2):262-6. doi: 10.1375/twin.15.2.262.


PMID- 22856325
OWN - NLM
STAT- MEDLINE
DCOM- 20130110
LR  - 20220408
IS  - 1472-6947 (Electronic)
IS  - 1472-6947 (Linking)
VI  - 12
DP  - 2012 Aug 2
TI  - Decision-making in healthcare: a practical application of partial least square
      path modelling to coverage of newborn screening programmes.
PG  - 83
LID - 10.1186/1472-6947-12-83 [doi]
AB  - BACKGROUND: Decision-making in healthcare is complex. Research on coverage
      decision-making has focused on comparative studies for several countries,
      statistical analyses for single decision-makers, the decision outcome and
      appraisal criteria. Accounting for decision processes extends the complexity, as 
      they are multidimensional and process elements need to be regarded as latent
      constructs (composites) that are not observed directly. The objective of this
      study was to present a practical application of partial least square path
      modelling (PLS-PM) to evaluate how it offers a method for empirical analysis of
      decision-making in healthcare. METHODS: Empirical approaches that applied PLS-PM 
      to decision-making in healthcare were identified through a systematic literature 
      search. PLS-PM was used as an estimation technique for a structural equation
      model that specified hypotheses between the components of decision processes and 
      the reasonableness of decision-making in terms of medical, economic and other
      ethical criteria. The model was estimated for a sample of 55 coverage decisions
      on the extension of newborn screening programmes in Europe. Results were
      evaluated by standard reliability and validity measures for PLS-PM. RESULTS:
      After modification by dropping two indicators that showed poor measures in the
      measurement models' quality assessment and were not meaningful for newborn
      screening, the structural equation model estimation produced plausible results.
      The presence of three influences was supported: the links between both
      stakeholder participation or transparency and the reasonableness of
      decision-making; and the effect of transparency on the degree of scientific
      rigour of assessment. Reliable and valid measurement models were obtained to
      describe the composites of 'transparency', 'participation', 'scientific rigour'
      and 'reasonableness'. CONCLUSIONS: The structural equation model was among the
      first applications of PLS-PM to coverage decision-making. It allowed testing of
      hypotheses in situations where there are links between several non-observable
      constructs. PLS-PM was compatible in accounting for the complexity of coverage
      decisions to obtain a more realistic perspective for empirical analysis. The
      model specification can be used for hypothesis testing by using larger sample
      sizes and for data in the full domain of health technologies.
FAU - Fischer, Katharina E
AU  - Fischer KE
AD  - Helmholtz Zentrum Munchen, German Research Center for Environmental Health,
      Institute for Health Economics and Health Care Management, Neuherberg, Germany.
      katharina.fischer@wiso.uni-hamburg.de
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120802
PL  - England
TA  - BMC Med Inform Decis Mak
JT  - BMC medical informatics and decision making
JID - 101088682
SB  - IM
MH  - *Decision Making
MH  - Delivery of Health Care/*standards
MH  - Humans
MH  - Infant, Newborn
MH  - Least-Squares Analysis
MH  - *Neonatal Screening
MH  - Reproducibility of Results
MH  - Research Design
PMC - PMC3444310
EDAT- 2012/08/04 06:00
MHDA- 2013/01/11 06:00
CRDT- 2012/08/04 06:00
PHST- 2011/10/24 00:00 [received]
PHST- 2012/07/28 00:00 [accepted]
PHST- 2012/08/04 06:00 [entrez]
PHST- 2012/08/04 06:00 [pubmed]
PHST- 2013/01/11 06:00 [medline]
AID - 1472-6947-12-83 [pii]
AID - 10.1186/1472-6947-12-83 [doi]
PST - epublish
SO  - BMC Med Inform Decis Mak. 2012 Aug 2;12:83. doi: 10.1186/1472-6947-12-83.


PMID- 22856053
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20120803
IS  - 0002-7979 (Print)
IS  - 0002-7979 (Linking)
VI  - 79
IP  - 1
DP  - 2012 Spring
TI  - The person who wears the white coat.
PG  - 33-6
AB  - Legal practice, charity care, and professionalism are the outward signs of dental
      competence, symbolized by the white coat. Ethics, the transformation of
      character, is a reflection of the person wearing the white coat. Patients and
      others assume the first three from the title "doctor." What they want to know is 
      what kind of person is wearing the white coat.
FAU - Chambers, David W
AU  - Chambers DW
AD  - University of the Pacific, Arthur A Dugoni School of Dentistry, USA.
      dchambers@pacfic.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Coll Dent
JT  - The Journal of the American College of Dentists
JID - 7503057
SB  - IM
MH  - Charities
MH  - Clinical Competence
MH  - Dentist-Patient Relations/ethics
MH  - Dentists/*ethics/legislation & jurisprudence
MH  - *Ethics, Dental
MH  - Humans
MH  - Interprofessional Relations/ethics
MH  - Professional Practice/legislation & jurisprudence
MH  - Trust
MH  - Uncompensated Care
EDAT- 2012/08/04 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/08/04 06:00
PHST- 2012/08/04 06:00 [entrez]
PHST- 2012/08/04 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
PST - ppublish
SO  - J Am Coll Dent. 2012 Spring;79(1):33-6.


PMID- 22855929
OWN - NLM
STAT- MEDLINE
DCOM- 20121210
LR  - 20211021
IS  - 1526-3347 (Electronic)
IS  - 0191-9601 (Linking)
VI  - 33
IP  - 8
DP  - 2012 Aug
TI  - Bioethics education and resources.
PG  - 370-3
LID - 10.1542/pir.33-8-370 [doi]
AB  - Ethics education based upon everyday ethical dilemmas can help trainees place
      themselves within the situation and encourage them to reflect on their role and
      responsibility in reaching its resolution.* Three elements can help augment the
      bioethics teaching experience: (a) identifying the ethical dilemma, (b) employing
      methods of ethical analysis, and(c) having knowledge of additional bioethics
      resources.An increasing number of bioethics resources are available to
      clinicians, including clinical ethics consultation (CEC) and print and Web-based 
      resources.
FAU - Opel, Douglas J
AU  - Opel DJ
AD  - Treuman Katz Center for Pediatric Bioethics, Seattle Children's Research
      Institute, and Department of Pediatrics, University of Washington School of
      Medicine, Seattle, WA, USA.
FAU - Olson, Maren E
AU  - Olson ME
LA  - eng
GR  - K23 HD069467/HD/NICHD NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Pediatr Rev
JT  - Pediatrics in review
JID - 8103046
SB  - IM
MH  - Curriculum
MH  - Education, Medical, Graduate/*methods
MH  - Ethics, Medical/*education
MH  - Internship and Residency/*methods
MH  - Pediatrics/education/*ethics
PMC - PMC4528335
EDAT- 2012/08/03 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/08/03 06:00
PHST- 2012/08/03 06:00 [entrez]
PHST- 2012/08/03 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - 33/8/370 [pii]
AID - 10.1542/pir.33-8-370 [doi]
PST - ppublish
SO  - Pediatr Rev. 2012 Aug;33(8):370-3. doi: 10.1542/pir.33-8-370.


PMID- 22855908
OWN - NLM
STAT- MEDLINE
DCOM- 20121226
LR  - 20190709
IS  - 1943-4723 (Electronic)
IS  - 0002-8177 (Linking)
VI  - 143
IP  - 8
DP  - 2012 Aug
TI  - What is the ethical course of action for a dentist whose patient's previous
      dentist may have treated the wrong tooth?
PG  - 917-8
FAU - Williams, Laura
AU  - Williams L
AD  - Laura Williams, DMD, practices general dentistry in Wenatchee, WA, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Am Dent Assoc
JT  - Journal of the American Dental Association (1939)
JID - 7503060
SB  - IM
MH  - Dentist-Patient Relations/*ethics
MH  - *Ethics, Dental
MH  - Humans
MH  - Interprofessional Relations/*ethics
MH  - Medical Errors/*ethics
MH  - Truth Disclosure/*ethics
EDAT- 2012/08/03 06:00
MHDA- 2012/12/27 06:00
CRDT- 2012/08/03 06:00
PHST- 2012/08/03 06:00 [entrez]
PHST- 2012/08/03 06:00 [pubmed]
PHST- 2012/12/27 06:00 [medline]
AID - S0002-8177(14)61806-7 [pii]
AID - 10.14219/jada.archive.2012.0298 [doi]
PST - ppublish
SO  - J Am Dent Assoc. 2012 Aug;143(8):917-8. doi: 10.14219/jada.archive.2012.0298.


PMID- 22855738
OWN - NLM
STAT- MEDLINE
DCOM- 20130116
LR  - 20120828
IS  - 1744-5019 (Electronic)
IS  - 0360-5310 (Linking)
VI  - 37
IP  - 4
DP  - 2012 Aug
TI  - Moral transhumanism: the next step.
PG  - 405-16
LID - 10.1093/jmp/jhs024 [doi]
AB  - Although transhumanism offers hope for the transcendence of human biological
      limitations, it generates many intrinsic and consequential ethical concerns. The 
      latter include issues such as the exacerbation of social inequalities and the
      exponentially increasing technological capacity to cause harm. To mitigate these 
      risks, many thinkers have initiated investigations into the possibility of moral 
      enhancement that could limit the power disparities facilitated by
      biotechnological enhancement. The arguments often focus on whether moral
      enhancement is morally permissible, or even obligatory, and remain largely in the
      realm of the hypothetical. This paper proposes that psilocybin may represent a
      viable, practical option for moral enhancement and that its further research in
      the context of moral psychology could comprise the next step in the development
      of moral transhumanism.
FAU - Tennison, Michael N
AU  - Tennison MN
AD  - University of Maryland Francis King Carey School of Law, 500 W. Baltimore Street,
      Baltimore, MD 21201-1786, USA. michael.tennison@umaryland.edu
LA  - eng
PT  - Journal Article
DEP - 20120801
PL  - United States
TA  - J Med Philos
JT  - The Journal of medicine and philosophy
JID - 7610512
SB  - IM
MH  - *Bioethics
MH  - Biomedical Enhancement/*ethics
MH  - Humans
MH  - *Morals
MH  - Philosophy, Medical
EDAT- 2012/08/03 06:00
MHDA- 2013/01/17 06:00
CRDT- 2012/08/03 06:00
PHST- 2012/08/03 06:00 [entrez]
PHST- 2012/08/03 06:00 [pubmed]
PHST- 2013/01/17 06:00 [medline]
AID - jhs024 [pii]
AID - 10.1093/jmp/jhs024 [doi]
PST - ppublish
SO  - J Med Philos. 2012 Aug;37(4):405-16. doi: 10.1093/jmp/jhs024. Epub 2012 Aug 1.


PMID- 22855630
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 4
DP  - 2012
TI  - The coronary CT angiography vision protocol: a prospective observational imaging 
      cohort study in patients undergoing non-cardiac surgery.
LID - 10.1136/bmjopen-2012-001474 [doi]
LID - e001474 [pii]
AB  - INTRODUCTION: At present, physicians have a limited ability to predict major
      cardiovascular complications after non-cardiac surgery and little is known about 
      the anatomy of coronary arteries associated with perioperative myocardial
      infarction. We have initiated the Coronary CT Angiography (CTA) VISION Study to
      (1) establish the predictive value of coronary CTA for perioperative myocardial
      infarction and death and (2) describe the coronary anatomy of patients that have 
      a perioperative myocardial infarction. METHODS AND ANALYSIS: The Coronary CTA
      VISION Study is prospective observational study. Preoperative coronary CTA will
      be performed in 1000-1500 patients with a history of vascular disease or at least
      three cardiovascular risk factors who are undergoing major elective non-cardiac
      surgery. Serial troponin will be measured 6-12 h after surgery and daily for the 
      first 3 days after surgery. Major vascular outcomes at 30 days and 1 year after
      surgery will be independently adjudicated. ETHICS AND DISSEMINATION: Coronary CTA
      results in a measurable radiation exposure that is similar to a nuclear perfusion
      scan (10-12 mSV). Treating physicians will be blinded to the CTA results until 30
      days after surgery in order to provide the most unbiased assessment of its
      prognostic capabilities. The only exception will be the presence of a left main
      stenosis >50%. This approach is supported by best available current evidence
      that, excluding left main disease, prophylatic revascularisation prior to
      non-cardiac surgery does not improve outcomes. An external safety and monitoring 
      committee is overseeing the study and will review outcome data at regular
      intervals. Publications describing the results of the study will be submitted to 
      major peer-reviewed journals and presented at international medical conferences.
FAU - Sheth, Tej
AU  - Sheth T
AD  - Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
FAU - Butler, Craig
AU  - Butler C
FAU - Chow, Benjamin
AU  - Chow B
FAU - Chan, M T V
AU  - Chan MT
FAU - Mitha, Ayesha
AU  - Mitha A
FAU - Nagele, Peter
AU  - Nagele P
FAU - Tandon, Vikas
AU  - Tandon V
FAU - Stewart, Lori
AU  - Stewart L
FAU - Graham, Michelle
AU  - Graham M
FAU - Choi, G Y S
AU  - Choi GY
FAU - Kisten, T
AU  - Kisten T
FAU - Woodard, P K
AU  - Woodard PK
FAU - Crean, Andrew
AU  - Crean A
FAU - Abdul Aziz, Y F
AU  - Abdul Aziz YF
FAU - Karthikeyan, G
AU  - Karthikeyan G
FAU - Chow, C K
AU  - Chow CK
FAU - Szczeklik, W
AU  - Szczeklik W
FAU - Markobrada, M
AU  - Markobrada M
FAU - Mastracci, T
AU  - Mastracci T
FAU - Devereaux, P J
AU  - Devereaux PJ
CN  - CTA VISION Investigators
LA  - eng
GR  - UL1 TR000448/TR/NCATS NIH HHS/United States
PT  - Journal Article
DEP - 20120731
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3449273
EDAT- 2012/08/03 06:00
MHDA- 2012/08/03 06:01
CRDT- 2012/08/03 06:00
PHST- 2012/08/03 06:00 [entrez]
PHST- 2012/08/03 06:00 [pubmed]
PHST- 2012/08/03 06:01 [medline]
AID - bmjopen-2012-001474 [pii]
AID - 10.1136/bmjopen-2012-001474 [doi]
PST - epublish
SO  - BMJ Open. 2012 Jul 31;2(4). pii: bmjopen-2012-001474. doi:
      10.1136/bmjopen-2012-001474. Print 2012.


PMID- 22855042
OWN - NLM
STAT- MEDLINE
DCOM- 20140220
LR  - 20211021
IS  - 1433-7347 (Electronic)
IS  - 0942-2056 (Linking)
VI  - 21
IP  - 7
DP  - 2013 Jul
TI  - Patient recall of surgical information after day case knee arthroscopy.
PG  - 1510-5
LID - 10.1007/s00167-012-2149-5 [doi]
AB  - PURPOSE: Day case knee arthroscopy is frequently performed on dedicated lists
      designed to optimise the throughput of patients. This could affect patient recall
      of clinical information with clinical, ethical and medicolegal consequences. The 
      purpose of this study was to assess patient recall after knee arthroscopy and
      identify potential contributory factors. METHODS: Seventy-two patients undergoing
      day case knee arthroscopy were provided with information about their surgery
      post-operatively and tested for recall of the information prior to discharge. All
      patients underwent cognitive assessment when information was delivered and again 
      when tested. Patient recall was correlated with demographic and anaesthetic
      factors and a multivariate regression model was used to identify risk factors for
      reduced recall. RESULTS: Recall overall was poor. Significant independent risk
      factors for reduced recall were reduced cognitive state at the time of
      information delivery and a shorter time between surgery and information delivery.
      Duration of anaesthesia, use of sedatives and use of opiate analgesia were not
      significantly correlated with recall. CONCLUSIONS: Information recall after day
      case knee athroscopy may be suboptimal. Allowing more time between surgery and
      information delivery may improve recall. However, this may be difficult during
      the course of a busy list and surgeons should consider using additional
      techniques to improve patient recall after surgery to reduce the risk of patient 
      anxiety or non-compliance. LEVEL OF EVIDENCE: IV.
FAU - da Assuncao, R E
AU  - da Assuncao RE
AD  - Nuffield Orthopaedic Centre, Windmill Road, Headington, Oxford OX37LD, UK.
      ruy@doctors.org.uk
FAU - Neely, J
AU  - Neely J
FAU - Lochab, J
AU  - Lochab J
FAU - Mizumi-Richards, N
AU  - Mizumi-Richards N
FAU - Barnett, A
AU  - Barnett A
FAU - Pandit, H
AU  - Pandit H
LA  - eng
PT  - Journal Article
DEP - 20120802
PL  - Germany
TA  - Knee Surg Sports Traumatol Arthrosc
JT  - Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
JID - 9314730
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Ambulatory Surgical Procedures/*psychology
MH  - Arthroscopy/*psychology
MH  - Female
MH  - Humans
MH  - Knee Joint/*surgery
MH  - Male
MH  - *Mental Recall
MH  - Middle Aged
MH  - Pain Measurement
MH  - Prospective Studies
MH  - Risk Factors
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
EDAT- 2012/08/03 06:00
MHDA- 2014/02/22 06:00
CRDT- 2012/08/03 06:00
PHST- 2011/11/29 00:00 [received]
PHST- 2012/07/19 00:00 [accepted]
PHST- 2012/08/03 06:00 [entrez]
PHST- 2012/08/03 06:00 [pubmed]
PHST- 2014/02/22 06:00 [medline]
AID - 10.1007/s00167-012-2149-5 [doi]
PST - ppublish
SO  - Knee Surg Sports Traumatol Arthrosc. 2013 Jul;21(7):1510-5. doi:
      10.1007/s00167-012-2149-5. Epub 2012 Aug 2.


PMID- 22854986
OWN - NLM
STAT- MEDLINE
DCOM- 20130620
LR  - 20211021
IS  - 1619-7089 (Electronic)
IS  - 1619-7070 (Linking)
VI  - 39
IP  - 11
DP  - 2012 Nov
TI  - Induction and repair of DNA double-strand breaks in blood lymphocytes of patients
      undergoing (1)(8)F-FDG PET/CT examinations.
PG  - 1712-9
LID - 10.1007/s00259-012-2201-1 [doi]
AB  - PURPOSE: The purpose of this study was to evaluate DNA double-strand breaks
      (DSBs) in blood lymphocytes of patients undergoing positron emission tomography
      (PET)/CT using gamma-H2AX immunofluorescence microscopy and to differentiate
      between (18)F-fluorodeoxyglucose (FDG) and CT-induced DNA lesions. METHODS: This 
      study was approved by the local Ethics Committee and complies with Health
      Insurance Portability and Accountability Act (HIPAA) requirements. After written 
      informed consent was obtained, 33 patients underwent whole-body (18)F-FDG PET/CT 
      (3 MBq/kg body weight, 170/100 reference mAs at 120 kV). The FDG PET and CT
      portions were performed as an initial CT immediately followed by the PET. Blood
      samples were obtained before, at various time points following (18)F-FDG
      application and up to 24 h after the CT scan. Distinct foci representing DSBs
      were quantified in isolated lymphocytes using fluorescence microscopy after
      staining against the phosphorylated histone variant gamma-H2AX. RESULTS: The DSB 
      values at the various time points were significantly different (p < 0.001). The
      median baseline level was 0.08/cell (range 0.06-0.12/cell). Peaks of
      radiation-induced DSBs were found 30 min after (18)F-FDG administration (median
      excess foci 0.11/cell, range 0.06-0.27/cell) and 5 min after CT (median excess
      foci 0.17/cell, range 0.05-0.54/cell). A significant correlation between
      CT-induced DSBs and dose length product was obtained (rho = 0.898, p < 0.001).
      After 24 h DSB values were still slightly but significantly elevated (median foci
      0.11/cell, range 0.10-0.14/cell, p = 0.003) compared to pre-exposure levels.
      CONCLUSION: PET/CT-induced DSBs can be monitored using gamma-H2AX
      immunofluorescence microscopy. Peak values may be obtained 30 min after (18)F-FDG
      injection and 5 min after CT. The radionuclide contributes considerably to the
      total DSB induction in this setting.
FAU - May, Matthias S
AU  - May MS
AD  - Department of Radiology, University Hospital Erlangen, Erlangen, Germany.
      matthias.may@uk-erlangen.de
FAU - Brand, Michael
AU  - Brand M
FAU - Wuest, Wolfgang
AU  - Wuest W
FAU - Anders, Katharina
AU  - Anders K
FAU - Kuwert, Torsten
AU  - Kuwert T
FAU - Prante, Olaf
AU  - Prante O
FAU - Schmidt, Daniela
AU  - Schmidt D
FAU - Maschauer, Simone
AU  - Maschauer S
FAU - Semelka, Richard C
AU  - Semelka RC
FAU - Uder, Michael
AU  - Uder M
FAU - Kuefner, Michael A
AU  - Kuefner MA
LA  - eng
PT  - Journal Article
DEP - 20120802
PL  - Germany
TA  - Eur J Nucl Med Mol Imaging
JT  - European journal of nuclear medicine and molecular imaging
JID - 101140988
RN  - 0 (Histones)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *DNA Breaks, Double-Stranded
MH  - *DNA Repair
MH  - Female
MH  - Fluorodeoxyglucose F18
MH  - Histones/metabolism
MH  - Humans
MH  - Lymphocytes/radiation effects
MH  - Male
MH  - Microscopy, Fluorescence
MH  - Middle Aged
MH  - *Multimodal Imaging
MH  - Phosphorylation
MH  - *Positron-Emission Tomography
MH  - *Tomography, X-Ray Computed
EDAT- 2012/08/03 06:00
MHDA- 2013/06/21 06:00
CRDT- 2012/08/03 06:00
PHST- 2012/02/29 00:00 [received]
PHST- 2012/07/16 00:00 [accepted]
PHST- 2012/08/03 06:00 [entrez]
PHST- 2012/08/03 06:00 [pubmed]
PHST- 2013/06/21 06:00 [medline]
AID - 10.1007/s00259-012-2201-1 [doi]
PST - ppublish
SO  - Eur J Nucl Med Mol Imaging. 2012 Nov;39(11):1712-9. doi:
      10.1007/s00259-012-2201-1. Epub 2012 Aug 2.


PMID- 22854978
OWN - NLM
STAT- MEDLINE
DCOM- 20130410
LR  - 20211021
IS  - 1432-1238 (Electronic)
IS  - 0342-4642 (Linking)
VI  - 38
IP  - 11
DP  - 2012 Nov
TI  - Regulation of advance directives in Italy: a bad law in the making.
PG  - 1897-900
LID - 10.1007/s00134-012-2656-3 [doi]
AB  - PURPOSE: The Advance Directives (ADs) have been adopted in many countries to
      defend patients' autonomy. In Italy, the role of ADs has recently been the
      subject of heated debate involving political parties and the Roman Catholic
      Church. In February 2009, the conservative government coalition presented a bill 
      of law on this issue. It has been passed by the Low Chamber and is now being
      discussed in the Senate. The purpose of the article is to highlight any possible 
      bill's contradiction with Italian Constitution, Italian Code of Medical Ethics
      (ICME), and Oviedo Convention contents, relevant for intensivists. METHODS:
      Analysis of bill's content in the light of Italian Constitution, ICME, Oviedo
      Convention articles and in comparison with French legislation regarding end of
      life (Leonetti law). RESULTS: In the Authors' point of view the bill's articles
      -limit the moral and judicial importance of four main issues as informed consent,
      permanent incapacity, artificial nutrition/hydration, and withdraw/withhold
      treatments. CONCLUSIONS: In the Authors' opinion the ADs must represent informed 
      preferences made freely by patients within the relationship with their
      physicians, as part of an advance care planning. When this relationship develops 
      in accordance with the ICME rules, it contains all of the ethical/professional
      dimensions to legitimate right choices in each case. The law should draw
      inspiration from ICME principles, assigning them a juridical power, acknowledging
      their validity in legitimating end-of-life decisions, and defining a framework of
      juridical legitimacy for these decisions without infringing on patients' right to
      autonomy with prescriptions on the care.
FAU - Gristina, Giuseppe Renato
AU  - Gristina GR
AD  - Trauma Center and Intensive Care, S. Camillo, Forlanini Hospital, Rome, Italy.
      geigris@fastwebnet.it
FAU - Martin, Erica
AU  - Martin E
FAU - Ranieri, Vito Marco
AU  - Ranieri VM
LA  - eng
PT  - Journal Article
DEP - 20120802
PL  - United States
TA  - Intensive Care Med
JT  - Intensive care medicine
JID - 7704851
SB  - IM
CIN - Intensive Care Med. 2013 Jan;39(1):157-8. PMID: 22990872
EIN - Intensive Care Med. 2014 Jan;40(1):144
MH  - Advance Directives/ethics/*legislation & jurisprudence
MH  - Constitution and Bylaws
MH  - Europe
MH  - Humans
MH  - Informed Consent/ethics/legislation & jurisprudence
MH  - Intensive Care Units
MH  - Italy
MH  - *Patient Rights
MH  - *Personal Autonomy
MH  - Politics
MH  - *Terminal Care
MH  - Withholding Treatment/ethics/legislation & jurisprudence
EDAT- 2012/08/03 06:00
MHDA- 2013/04/11 06:00
CRDT- 2012/08/03 06:00
PHST- 2012/01/30 00:00 [received]
PHST- 2012/07/12 00:00 [accepted]
PHST- 2012/08/03 06:00 [entrez]
PHST- 2012/08/03 06:00 [pubmed]
PHST- 2013/04/11 06:00 [medline]
AID - 10.1007/s00134-012-2656-3 [doi]
PST - ppublish
SO  - Intensive Care Med. 2012 Nov;38(11):1897-900. doi: 10.1007/s00134-012-2656-3.
      Epub 2012 Aug 2.


PMID- 22854919
OWN - NLM
STAT- MEDLINE
DCOM- 20130709
LR  - 20211021
IS  - 1432-2161 (Electronic)
IS  - 0364-2348 (Linking)
VI  - 42
IP  - 2
DP  - 2013 Feb
TI  - Subchondral impaction fractures of the non-weight-bearing portion of the lateral 
      femoral condyle.
PG  - 177-85
LID - 10.1007/s00256-012-1492-4 [doi]
AB  - OBJECTIVE: To document the first report of intra-articular, non-weight-bearing,
      impaction fractures of the lateral femoral condyle. MATERIALS & METHODS:
      Institutional Review Board and Regional Ethics Committee approval for this study 
      was obtained and patient informed consent deemed unnecessary. We prospectively
      documented all potential cases of non-weight-bearing posterior subchondral
      impaction fractures of the femoral condyles diagnosed on magnetic resonance
      imaging (MRI) of the knee performed at our institution between January 2006 and
      December 2011. The cases were reviewed and discussed by three experienced
      musculoskeletal radiologists and only cases satisfying pre-defined MRI criteria
      were included. RESULTS: Sixteen cases of intra-articular impaction fractures in a
      posterior, non-weight-bearing area of the lateral femoral condyle were diagnosed 
      in patients with a mean age of 40. Eight were associated with recreational sports
      activities and 4 with repeated kneeling. There were no fractures documented in
      the non-weight-bearing aspect of the medial femoral condyles. Proposed underlying
      mechanisms for development of this type of fracture are presented. CONCLUSION:
      Awareness, along with a high level of suspicion, that non-specific knee pain,
      especially in patients involved in athletic activities, could be due to
      intra-articular impaction fractures of the non-weight-bearing posterior aspect of
      the lateral femoral condyle is essential and MRI is the mainstay of diagnosis.
FAU - Depasquale, Ruben
AU  - Depasquale R
AD  - Radiology Department, Robert Jones and Agnes Hunt Orthopaedic and District
      Hospitals NHS Trust, Gobowen, Oswestry, Shropshire, SY10 7AG, UK.
FAU - Fotiadou, Anastasia
AU  - Fotiadou A
FAU - Kumar, Dalavaye Suresh
AU  - Kumar DS
FAU - Lalam, Radhesh
AU  - Lalam R
FAU - Tins, Bernhard
AU  - Tins B
FAU - Tyrrell, Prudencia N M
AU  - Tyrrell PN
FAU - Singh, Jaspreet
AU  - Singh J
FAU - Cassar-Pullicino, Victor N
AU  - Cassar-Pullicino VN
LA  - eng
PT  - Journal Article
DEP - 20120802
PL  - Germany
TA  - Skeletal Radiol
JT  - Skeletal radiology
JID - 7701953
SB  - IM
MH  - Adult
MH  - Female
MH  - Femoral Fractures/*diagnosis/*epidemiology
MH  - Fractures, Compression/*diagnosis/*epidemiology
MH  - Humans
MH  - Incidence
MH  - Magnetic Resonance Imaging/*statistics & numerical data
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - United Kingdom/epidemiology
MH  - Weight-Bearing
EDAT- 2012/08/03 06:00
MHDA- 2013/07/10 06:00
CRDT- 2012/08/03 06:00
PHST- 2012/05/01 00:00 [received]
PHST- 2012/07/16 00:00 [accepted]
PHST- 2012/06/25 00:00 [revised]
PHST- 2012/08/03 06:00 [entrez]
PHST- 2012/08/03 06:00 [pubmed]
PHST- 2013/07/10 06:00 [medline]
AID - 10.1007/s00256-012-1492-4 [doi]
PST - ppublish
SO  - Skeletal Radiol. 2013 Feb;42(2):177-85. doi: 10.1007/s00256-012-1492-4. Epub 2012
      Aug 2.


PMID- 22854057
OWN - NLM
STAT- MEDLINE
DCOM- 20130515
LR  - 20200518
IS  - 1873-6327 (Electronic)
IS  - 0306-4603 (Linking)
VI  - 38
IP  - 2
DP  - 2013 Feb
TI  - Ethical implications of research on craving.
PG  - 1593-1599
LID - S0306-4603(12)00279-1 [pii]
LID - 10.1016/j.addbeh.2012.07.002 [doi]
AB  - Cravings, intense desires to experience the effects of a drug, are widely
      regarded as significant impediments to overcoming addiction, although their role 
      in relapse may be overstated. Scientists and clinicians wish to better understand
      the neurobiological and cognitive basis of craving so that they may develop
      psychotherapeutic, pharmacological and other medical methods to reduce craving
      and thereby drug use. The conduct of such research raises significant ethical
      issues. When recruiting individuals and conducting this research, scientists need
      to ensure that substance dependent participants have the capacity to provide free
      and uncoerced consent. This is especially the case in studies in which dependent 
      participants are given their drug of addiction or provided with other inducements
      to participate (e.g. financial incentives) that may undermine their ability to
      fully consider the risks of participation. Treatments for addiction that seek to 
      reduce cravings may also carry risks. This includes psychotherapeutic approaches,
      as well as pharmacological and medical treatments. Clinicians need to consider
      the risks and benefits of treatment and carefully communicate these to patients. 
      The desire to reduce urges to use drugs should not be employed to justify
      potentially harmful and ineffective treatments. The safety and effectiveness of
      emerging treatments should be assessed by well conducted randomized controlled
      clinical trials.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Carter, Adrian
AU  - Carter A
AD  - The University of Queensland, UQ Centre for Clinical Research, Royal Brisbane and
      Women's Hospital Campus, Herston QLD 4029, Australia. Electronic address:
      adrian.carter@uq.edu.au.
FAU - Hall, Wayne
AU  - Hall W
AD  - The University of Queensland, UQ Centre for Clinical Research, Royal Brisbane and
      Women's Hospital Campus, Herston QLD 4029, Australia; The University of
      Queensland, Queensland Brain Institute, QBI Building (#79), St Lucia QLD 4072,
      Australia. Electronic address: w.hall@uq.edu.au.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120717
PL  - England
TA  - Addict Behav
JT  - Addictive behaviors
JID - 7603486
SB  - IM
MH  - Adult
MH  - Behavior, Addictive/drug therapy/*psychology/therapy
MH  - *Ethics, Research
MH  - Female
MH  - Humans
MH  - *Informed Consent
MH  - *Mental Competency
MH  - Patient Selection
MH  - Research Subjects/psychology
MH  - Secondary Prevention
MH  - Substance-Related Disorders/drug therapy/*psychology/therapy
EDAT- 2012/08/03 06:00
MHDA- 2013/05/17 06:00
CRDT- 2012/08/03 06:00
PHST- 2012/02/01 00:00 [received]
PHST- 2012/07/09 00:00 [revised]
PHST- 2012/07/10 00:00 [accepted]
PHST- 2012/08/03 06:00 [entrez]
PHST- 2012/08/03 06:00 [pubmed]
PHST- 2013/05/17 06:00 [medline]
AID - S0306-4603(12)00279-1 [pii]
AID - 10.1016/j.addbeh.2012.07.002 [doi]
PST - ppublish
SO  - Addict Behav. 2013 Feb;38(2):1593-1599. doi: 10.1016/j.addbeh.2012.07.002. Epub
      2012 Jul 17.


PMID- 22854011
OWN - NLM
STAT- MEDLINE
DCOM- 20130207
LR  - 20211021
IS  - 1528-8447 (Electronic)
IS  - 1526-5900 (Linking)
VI  - 13
IP  - 9
DP  - 2012 Sep
TI  - Analgesic placebo treatment perceptions: acceptability, efficacy, and knowledge.
PG  - 891-900
LID - 10.1016/j.jpain.2012.06.003 [doi]
AB  - UNLABELLED: Current evidence supports the efficacy of placebo analgesia and
      illustrates that patients may be open to placebo use despite uncertainty
      regarding its mechanisms. Debate persists, however, concerning the ethics of
      placebo treatments. The purpose of the present web-based study was to expand upon
      the empirical literature on placebo analgesia ethics and acceptability.
      Participants (n = 100) provided their definition of a placebo and responded to 24
      questions addressing placebo analgesia perceived knowledge, acceptability,
      effectiveness, and likelihood of placebo use among different health care
      providers. Results support previous research on the effects of placebo on
      negative mood and health care provider attributions, with findings illustrating
      that negative consequences of administration were largely mitigated by a
      beneficial treatment outcome. Results showed that participants conceptualized
      placebo as predominately inert and were mixed regarding interpretations of
      placebo effectiveness. Though acceptability ratings were dependent on the context
      of placebo administration, participants endorsing even moderate placebo
      acceptability were more open to placebo interventions and reported overall more
      positive treatment outcomes. Participants believed that placebos were used
      differentially among health care providers. Additional studies are needed to
      determine if placebo education can beneficially impact perceptions of placebo
      analgesia knowledge, acceptability, and treatment effectiveness. PERSPECTIVE:
      This study presents an examination of analgesic placebo treatment perceived
      acceptability, efficacy, and knowledge among lay individuals. Our findings
      highlight the importance of assessing placebo conceptualizations and treatment
      perceptions in evaluating placebo ethics-a highly relevant finding that informs
      the clinical use of placebo components in managing pain.
CI  - Copyright (c) 2012 American Pain Society. Published by Elsevier Inc. All rights
      reserved.
FAU - Kisaalita, Nkaku R
AU  - Kisaalita NR
AD  - Center for Pain Research and Behavioral Health, Department of Clinical and Health
      Psychology, University of Florida, Gainesville, Florida 32610-0165, USA.
FAU - Robinson, Michael E
AU  - Robinson ME
LA  - eng
GR  - P30 AG028740/AG/NIA NIH HHS/United States
GR  - R01 AT001424/AT/NCCIH NIH HHS/United States
GR  - 5R01AT001424-06/AT/NCCIH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20120731
PL  - United States
TA  - J Pain
JT  - The journal of pain
JID - 100898657
RN  - 0 (Analgesics)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Analgesics/*therapeutic use
MH  - Analysis of Variance
MH  - Cluster Analysis
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pain/*drug therapy/*psychology
MH  - Pain Management
MH  - *Patient Acceptance of Health Care
MH  - Perception/*drug effects
MH  - *Placebo Effect
MH  - Reproducibility of Results
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC3438323
MID - NIHMS390050
EDAT- 2012/08/03 06:00
MHDA- 2013/02/08 06:00
CRDT- 2012/08/03 06:00
PHST- 2012/04/12 00:00 [received]
PHST- 2012/06/07 00:00 [revised]
PHST- 2012/06/13 00:00 [accepted]
PHST- 2012/08/03 06:00 [entrez]
PHST- 2012/08/03 06:00 [pubmed]
PHST- 2013/02/08 06:00 [medline]
AID - S1526-5900(12)00689-X [pii]
AID - 10.1016/j.jpain.2012.06.003 [doi]
PST - ppublish
SO  - J Pain. 2012 Sep;13(9):891-900. doi: 10.1016/j.jpain.2012.06.003. Epub 2012 Jul
      31.


PMID- 22853932
OWN - NLM
STAT- MEDLINE
DCOM- 20130708
LR  - 20211021
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Linking)
VI  - 120
IP  - 8
DP  - 2012 Aug
TI  - Revised ethics guidelines for environmental epidemiologists.
PG  - a299-301
LID - 10.1289/ehp.1205562 [doi]
FAU - Kramer, Shira
AU  - Kramer S
FAU - Soskolne, Colin L
AU  - Soskolne CL
FAU - Mustapha, B Adetoun
AU  - Mustapha BA
FAU - Al-Delaimy, Wael K
AU  - Al-Delaimy WK
LA  - eng
PT  - Editorial
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
SB  - IM
MH  - Conflict of Interest
MH  - *Epidemiology/ethics
MH  - *Ethics
MH  - *Guidelines as Topic
MH  - Workforce
PMC - PMC3440101
EDAT- 2012/08/03 06:00
MHDA- 2013/07/09 06:00
CRDT- 2012/08/03 06:00
PHST- 2012/08/03 06:00 [entrez]
PHST- 2012/08/03 06:00 [pubmed]
PHST- 2013/07/09 06:00 [medline]
AID - 10.1289/ehp.1205562 [doi]
PST - ppublish
SO  - Environ Health Perspect. 2012 Aug;120(8):a299-301. doi: 10.1289/ehp.1205562.


PMID- 22853883
OWN - NLM
STAT- MEDLINE
DCOM- 20130604
LR  - 20120827
IS  - 1532-1932 (Electronic)
IS  - 1521-6934 (Linking)
VI  - 26
IP  - 5
DP  - 2012 Oct
TI  - Advances in fetal genetic diagnosis and therapy: ethical issues and appropriate
      technology in cost-restrained countries.
PG  - 531-40
LID - 10.1016/j.bpobgyn.2012.06.004 [doi]
AB  - The advent of ultrasound in the 1970s heralded a milestone that could give
      real-time information about fetal abnormalities, and thereby improve diagnostic
      accuracy. This knowledge could not be used effectively to benefit the fetus for
      which it was intended. The 1980s saw science catching up with diagnostic
      advances, and fetal abnormalities could realistically be treated with an
      expectation of satisfactory outcomes. As a result, parents could have realistic
      expectations of having healthy children. Prenatal diagnosis is the first step
      towards this realisation, as diagnosis can be followed by intrauterine treatment.
      Scientists have realised that, if an abnormality can be corrected prenatally,
      prognosis can be improved significantly, as the initial problem does not
      necessarily threaten the fetus; therefore, if the prenatal condition can be dealt
      with early, then the downstream repercussions can be eliminated. In this chapter,
      we address ethical issues in prenatal diagnosis and fetal therapy.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Titus, Mokete J
AU  - Titus MJ
AD  - Department of Obstetrics and Gynaecology, Pietermaritzburg Metropolitan Hospitals
      Complex, Grey's Hospital, KwaZulu-Natal, South Africa.
FAU - Moodley, Jagidesa
AU  - Moodley J
LA  - eng
PT  - Journal Article
DEP - 20120731
PL  - Netherlands
TA  - Best Pract Res Clin Obstet Gynaecol
JT  - Best practice & research. Clinical obstetrics & gynaecology
JID - 101121582
SB  - IM
MH  - Developing Countries
MH  - Female
MH  - Fetal Diseases/*diagnosis/genetics/therapy
MH  - Fetal Therapies/*ethics
MH  - Genetic Testing/ethics
MH  - Humans
MH  - Informed Consent
MH  - *Personal Autonomy
MH  - Pregnancy
MH  - Prenatal Diagnosis/*ethics/methods
EDAT- 2012/08/03 06:00
MHDA- 2013/06/05 06:00
CRDT- 2012/08/03 06:00
PHST- 2012/01/05 00:00 [received]
PHST- 2012/05/14 00:00 [revised]
PHST- 2012/06/04 00:00 [accepted]
PHST- 2012/08/03 06:00 [entrez]
PHST- 2012/08/03 06:00 [pubmed]
PHST- 2013/06/05 06:00 [medline]
AID - S1521-6934(12)00101-0 [pii]
AID - 10.1016/j.bpobgyn.2012.06.004 [doi]
PST - ppublish
SO  - Best Pract Res Clin Obstet Gynaecol. 2012 Oct;26(5):531-40. doi:
      10.1016/j.bpobgyn.2012.06.004. Epub 2012 Jul 31.


PMID- 22852548
OWN - NLM
STAT- MEDLINE
DCOM- 20121102
LR  - 20181201
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 12
IP  - 8
DP  - 2012
TI  - Advocacy through a prism: a response to commentaries on "patient advocacy in
      clinical ethics consultation".
PG  - W1-3
LID - 10.1080/15265161.2012.705635 [doi]
FAU - Rasmussen, Lisa M
AU  - Rasmussen LM
AD  - Department of Philosophy, University of NorthCarolina, Charlotte, 9201 University
      City Blvd., Charlotte, NC 28223, USA. lrasmuss@uncc.edu
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2012;12(8):1-9. PMID: 22852531
MH  - *Conflict of Interest
MH  - *Ethicists
MH  - *Ethics Consultation
MH  - *Ethics, Clinical
MH  - Humans
MH  - *Patient Advocacy
MH  - *Professional Role
EDAT- 2012/08/03 06:00
MHDA- 2012/11/03 06:00
CRDT- 2012/08/03 06:00
PHST- 2012/08/03 06:00 [entrez]
PHST- 2012/08/03 06:00 [pubmed]
PHST- 2012/11/03 06:00 [medline]
AID - 10.1080/15265161.2012.705635 [doi]
PST - ppublish
SO  - Am J Bioeth. 2012;12(8):W1-3. doi: 10.1080/15265161.2012.705635.


PMID- 22852537
OWN - NLM
STAT- MEDLINE
DCOM- 20121102
LR  - 20181201
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 12
IP  - 8
DP  - 2012
TI  - Will the last health care professional to forgo patient advocacy please call an
      ethics consult?
PG  - 19-20
LID - 10.1080/15265161.2012.692447 [doi]
FAU - Allen, William Lawrence
AU  - Allen WL
AD  - University of Florida, College of Medicine, 1600 SW Archer Road, Gainesville, FL 
      32610, USA. wmallen@ufl.edu
FAU - Moseley, Ray Edward
AU  - Moseley RE
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2012;12(8):1-9. PMID: 22852531
MH  - *Conflict of Interest
MH  - *Ethicists
MH  - *Ethics Consultation
MH  - *Ethics, Clinical
MH  - Humans
MH  - *Patient Advocacy
MH  - *Professional Role
EDAT- 2012/08/03 06:00
MHDA- 2012/11/03 06:00
CRDT- 2012/08/03 06:00
PHST- 2012/08/03 06:00 [entrez]
PHST- 2012/08/03 06:00 [pubmed]
PHST- 2012/11/03 06:00 [medline]
AID - 10.1080/15265161.2012.692447 [doi]
PST - ppublish
SO  - Am J Bioeth. 2012;12(8):19-20. doi: 10.1080/15265161.2012.692447.


PMID- 22852536
OWN - NLM
STAT- MEDLINE
DCOM- 20121102
LR  - 20181201
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 12
IP  - 8
DP  - 2012
TI  - A place for ethics? A place for advocacy?
PG  - 17-8
LID - 10.1080/15265161.2012.692446 [doi]
FAU - Pierce, Robin L
AU  - Pierce RL
AD  - Delft University of Technology, Biotechnology, Delft, The Netherlands.
      r.l.pierce@tudelft.nl; pierce7@post.harvard.edu
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2012;12(8):1-9. PMID: 22852531
MH  - *Conflict of Interest
MH  - *Ethicists
MH  - *Ethics Consultation
MH  - *Ethics, Clinical
MH  - Humans
MH  - *Patient Advocacy
MH  - *Professional Role
EDAT- 2012/08/03 06:00
MHDA- 2012/11/03 06:00
CRDT- 2012/08/03 06:00
PHST- 2012/08/03 06:00 [entrez]
PHST- 2012/08/03 06:00 [pubmed]
PHST- 2012/11/03 06:00 [medline]
AID - 10.1080/15265161.2012.692446 [doi]
PST - ppublish
SO  - Am J Bioeth. 2012;12(8):17-8. doi: 10.1080/15265161.2012.692446.


PMID- 22852535
OWN - NLM
STAT- MEDLINE
DCOM- 20121102
LR  - 20181201
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 12
IP  - 8
DP  - 2012
TI  - Clinical ethics consultants: advocates for both patients and clinicians.
PG  - 15-7
LID - 10.1080/15265161.2012.692435 [doi]
FAU - Kon, Alexander A
AU  - Kon AA
AD  - Naval Medical Center San Diego, 34800 Bob Wilson Dr., San Diego, CA 92134, USA.
      kon.sandiego@gmail.com
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2012;12(8):1-9. PMID: 22852531
MH  - *Conflict of Interest
MH  - *Ethicists
MH  - *Ethics Consultation
MH  - *Ethics, Clinical
MH  - Humans
MH  - *Patient Advocacy
MH  - *Professional Role
EDAT- 2012/08/03 06:00
MHDA- 2012/11/03 06:00
CRDT- 2012/08/03 06:00
PHST- 2012/08/03 06:00 [entrez]
PHST- 2012/08/03 06:00 [pubmed]
PHST- 2012/11/03 06:00 [medline]
AID - 10.1080/15265161.2012.692435 [doi]
PST - ppublish
SO  - Am J Bioeth. 2012;12(8):15-7. doi: 10.1080/15265161.2012.692435.


PMID- 22852534
OWN - NLM
STAT- MEDLINE
DCOM- 20121102
LR  - 20181201
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 12
IP  - 8
DP  - 2012
TI  - Do clinical ethics consultants have a fiduciary responsibility to the patient?
PG  - 13-5
LID - 10.1080/15265161.2012.692438 [doi]
FAU - Spike, Jeffrey P
AU  - Spike JP
AD  - McGovernCenter for Humanities and Ethics,University of Texas-Houston, 6431 Fannin
      Street, JJL 410, Houston TX 77030, USA. jeffrey.p.spike@uth.tmc.edu
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2012;12(8):1-9. PMID: 22852531
MH  - *Conflict of Interest
MH  - *Ethicists
MH  - *Ethics Consultation
MH  - *Ethics, Clinical
MH  - Humans
MH  - *Patient Advocacy
MH  - *Professional Role
EDAT- 2012/08/03 06:00
MHDA- 2012/11/03 06:00
CRDT- 2012/08/03 06:00
PHST- 2012/08/03 06:00 [entrez]
PHST- 2012/08/03 06:00 [pubmed]
PHST- 2012/11/03 06:00 [medline]
AID - 10.1080/15265161.2012.692438 [doi]
PST - ppublish
SO  - Am J Bioeth. 2012;12(8):13-5. doi: 10.1080/15265161.2012.692438.


PMID- 22852533
OWN - NLM
STAT- MEDLINE
DCOM- 20121102
LR  - 20181201
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 12
IP  - 8
DP  - 2012
TI  - Empowering, teaching, and occasionally advocating: clinical ethics consultants'
      duties to all of the participants in the process.
PG  - 11-3
LID - 10.1080/15265161.2012.692443 [doi]
FAU - Antommaria, Armand H Matheny
AU  - Antommaria AH
AD  - Division of Pediatric Inpatient Medicine, Division of Medical Ethics and
      Humanities, University of Utah School of Medicine, 100 N Mario Capecchi Drive,
      Salt Lake City, UT 84113, USA. armand.antommaria@hsc.utah.edu
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2012;12(8):1-9. PMID: 22852531
MH  - *Conflict of Interest
MH  - *Ethicists
MH  - *Ethics Consultation
MH  - *Ethics, Clinical
MH  - Humans
MH  - *Patient Advocacy
MH  - *Professional Role
EDAT- 2012/08/03 06:00
MHDA- 2012/11/03 06:00
CRDT- 2012/08/03 06:00
PHST- 2012/08/03 06:00 [entrez]
PHST- 2012/08/03 06:00 [pubmed]
PHST- 2012/11/03 06:00 [medline]
AID - 10.1080/15265161.2012.692443 [doi]
PST - ppublish
SO  - Am J Bioeth. 2012;12(8):11-3. doi: 10.1080/15265161.2012.692443.


PMID- 22852531
OWN - NLM
STAT- MEDLINE
DCOM- 20121102
LR  - 20120802
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 12
IP  - 8
DP  - 2012
TI  - Patient advocacy in clinical ethics consultation.
PG  - 1-9
LID - 10.1080/15265161.2012.692434 [doi]
AB  - The question of whether clinical ethics consultants may engage in patient
      advocacy in the course of consultation has not been addressed, but it highlights 
      for the field that consultants' allegiances, and the boundaries of appropriate
      professional practice, must be better understood. I consider arguments for and
      against patient advocacy in clinical ethics consultation, which demonstrate that 
      patient advocacy is permissible, but not central to the practice of consultation.
      I then offer four recommendations for consultants who engage in patient advocacy,
      and consider the implications of this issue for the field.(1).
FAU - Rasmussen, Lisa M
AU  - Rasmussen LM
AD  - Department of Philosophy, University of NorthCarolina, Charlotte, 9201 University
      City Blvd., Charlotte, NC 28223, USA. lrasmuss@uncc.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CIN - Am J Bioeth. 2012;12(8):10-1. PMID: 22852532
CIN - Am J Bioeth. 2012;12(8):11-3. PMID: 22852533
CIN - Am J Bioeth. 2012;12(8):13-5. PMID: 22852534
CIN - Am J Bioeth. 2012;12(8):15-7. PMID: 22852535
CIN - Am J Bioeth. 2012;12(8):17-8. PMID: 22852536
CIN - Am J Bioeth. 2012;12(8):19-20. PMID: 22852537
CIN - Am J Bioeth. 2012;12(8):W1-3. PMID: 22852548
MH  - Adolescent
MH  - Adult
MH  - Blood Transfusion/ethics
MH  - *Conflict of Interest
MH  - *Ethicists
MH  - *Ethics Consultation/standards
MH  - *Ethics, Clinical
MH  - Homeless Persons
MH  - Humans
MH  - Intellectual Disability
MH  - Jehovah's Witnesses
MH  - Minors
MH  - Negotiating
MH  - Neoplasms/therapy
MH  - *Patient Advocacy
MH  - Practice Guidelines as Topic
MH  - *Professional Role
MH  - Religion and Medicine
EDAT- 2012/08/03 06:00
MHDA- 2012/11/03 06:00
CRDT- 2012/08/03 06:00
PHST- 2012/08/03 06:00 [entrez]
PHST- 2012/08/03 06:00 [pubmed]
PHST- 2012/11/03 06:00 [medline]
AID - 10.1080/15265161.2012.692434 [doi]
PST - ppublish
SO  - Am J Bioeth. 2012;12(8):1-9. doi: 10.1080/15265161.2012.692434.


PMID- 22852509
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20191210
IS  - 0305-5000 (Print)
IS  - 0305-5000 (Linking)
VI  - 39
IP  - 5
DP  - 2012 Jun
TI  - Ethical marketing in'aesthetic' ('esthetic') or'cosmetic dentistry'. Part 1.
PG  - 313-6, 318-20, 323-4 passim
AB  - UNLABELLED: Prior to undertaking any elective,'cosmetic' dental procedures, it is
      vital for the treating dentist to discuss the merits and drawbacks of all viable 
      options. It is important that the patient understands what the consequences and
      limitations of treatment are likely to be, and what the potential failures could 
      entail later in his/her life. Informed consent should be obtained (preferably in 
      writing) and the clinical notes and records should be clearly documented, with
      accurate and concise details provided of all the investigations carried out, and 
      their findings, as well as including details of the various discussions that have
      taken place. Dentists need to be aware of the existence of heightened
      expectations in this group of patients and be cautious about accepting patients
      who have unrealistic 'cosmetic' expectations. Where possible, cosmetic or
      aesthetic dental treatment should be provided which is minimally destructive and,
      in the long-term, be in the 'best interests' of the patient. Important matters
      such as the gaining of informed consent and maintaining meticulous,
      contemporaneous dental records will also be emphasized. It is hoped that the
      article will provide clear definitions of some commonly used terms such as
      'ethical marketing', 'ethics', and 'values', which are often used in association 
      with the marketing, planning and undertaking of supposedly 'cosmetic' dental
      procedures. The important role of less invasive alternative treatment options
      will also be emphasized. CLINICAL RELEVANCE: The aims of this article are to
      consider the common pitfalls that may arise when contemplating the marketing and 
      provision of invasive,'cosmetic, dental restorations and to discuss how best to
      avoid a dento-legal claim where such treatment plans may not fulfil the patient's
      desired outcome.
FAU - Kelleher, Martin G D
AU  - Kelleher MG
AD  - King's College Hospital, London SE5 9RS.
FAU - Djemal, Serpil
AU  - Djemal S
FAU - Lewis, Nicholas
AU  - Lewis N
LA  - eng
PT  - Journal Article
PL  - England
TA  - Dent Update
JT  - Dental update
JID - 7805969
CIN - Dent Update. 2012 Oct;39(8):588-9. PMID: 23167210
CIN - Dent Update. 2012 Oct;39(8):589. PMID: 23167211
MH  - Advertising/ethics
MH  - Attitude to Health
MH  - Beauty Culture/ethics
MH  - Dental Care/ethics
MH  - Dental Prosthesis/ethics
MH  - Dental Records
MH  - Dental Veneers/ethics
MH  - Dentist-Patient Relations/*ethics
MH  - *Esthetics, Dental
MH  - *Ethics, Dental
MH  - Female
MH  - Humans
MH  - Informed Consent/ethics
MH  - Male
MH  - Marketing of Health Services/*ethics
MH  - Minimally Invasive Surgical Procedures/ethics
MH  - Motivation
MH  - Patient Care Planning/ethics
MH  - Risk Assessment/ethics
MH  - Tooth Bleaching/ethics
MH  - Tooth Preparation/ethics
EDAT- 2012/08/03 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/08/03 06:00
PHST- 2012/08/03 06:00 [entrez]
PHST- 2012/08/03 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
AID - 10.12968/denu.2012.39.5.313 [doi]
PST - ppublish
SO  - Dent Update. 2012 Jun;39(5):313-6, 318-20, 323-4 passim. doi:
      10.12968/denu.2012.39.5.313.


PMID- 22852485
OWN - NLM
STAT- MEDLINE
DCOM- 20120904
LR  - 20131121
IS  - 1041-5505 (Print)
IS  - 1041-5505 (Linking)
IP  - 165
DP  - 2012 Feb
TI  - Allergic inflammation in the human lower respiratory tract affected by exposure
      to diesel exhaust.
PG  - 5-43; discussion 45-64
AB  - To improve understanding of human health risks from exposure to diesel exhaust
      particles (DEP*), we tested whether immunologic effects previously observed in
      the human nose also occur in the lower airways. Our overall hypothesis was that
      cell influx and production of cytokines, chemokines, immunoglobulin E (IgE), and 
      other mediators, which would be measurable in sputum and blood, occur in people
      with asthma after realistic controlled exposures to diesel exhaust (DE). In Phase
      1 we tested for direct effects of DE in subjects with clinically undifferentiated
      mild asthma. In Phase 2 we tested whether DE exposure would exacerbate response
      to inhaled cat allergen in subjects with both asthma and cat sensitivity. The
      exposure facility was a controlled-environment chamber supplied with DE from an
      idling medium-duty truck with ultra-low-sulfur fuel and no catalytic converter.
      We exposed volunteers for 2 hours with intermittent exercise to exhaust with DEP 
      mass concentration near 100 microg/m3. Exposures to nitrogen dioxide (NO2) near
      0.35 ppm (similar to its concentration in DE) and to filtered air (FA) served as 
      controls. Blood was drawn before exposure on day 1 and again the next morning
      (day 2). Sputum was induced only on day 2. Bronchial reactivity was measured -1
      hour after exposure ended. Supplementary endpoints included measures of blood
      coagulation status, cardiopulmonary physiology, and symptoms. Each phase employed
      15 subjects with asthma; 3 subjects participated in both phases. In Phase 1,
      airway reactivity was measured with inhaled methacholine; in Phase 2, with
      inhaled cat allergen. We found little biologic response to DE exposure compared
      with exposure to control atmospheres. In Phase 1, interleukin 4 (IL-4) in sputum 
      showed an estimated 1.7-fold increase attributable to DE exposure, which was
      close to statistical significance; airway resistance increased modestly but
      significantly on day 2 after DE exposure; and nonspecific symptom scores
      increased significantly during DE exposure. In Phase 2, indicators of airway
      inflammation in sputum showed a possibly meaningful response: polymorphonuclear
      leukocytes (PMNs) and eosinophils increased after DE exposure, whereas
      macrophages decreased. IgE in sputum and the bronchoconstrictive response to cat 
      allergen varied significantly between atmospheres, but not in patterns consistent
      with our primary hypothesis. Symptom score changes relatable to DE exposure were 
      smaller than those in Phase 1 and not statistically significant. Controlled
      exposures, lasting 2 hours with intermittent exercise, to diluted DE at a
      particle mass concentration of 100 microg/m3 did not evoke clear and consistent
      lower-airway or systemic immunologic or inflammatory responses in mildly
      asthmatic subjects, with or without accompanying challenge with cat allergen.
      Likewise, these DE exposures did not significantly increase nonspecific or
      allergen-specific bronchial reactivity. A few isolated statistically significant 
      or near-significant changes were observed during and after DE exposure, including
      increases in nonspecific symptoms (e.g., headache, nausea) suggestive of subtle, 
      rapid-onset systemic effects. It is possible the lower respiratory tract is more 
      resistant than the nose to adjuvant effects of diesel particles on allergic
      inflammation, so that no meaningful effects occur under exposure conditions like 
      these. Alternatively, the experimental conditions may have been near a threshold 
      for finding effects. That is, important lower respiratory effects may occur but
      may be detectable experimentally with slightly higher DEP concentrations, longer 
      exposures, more invasive testing (e.g., bronchoalveolar lavage), or more
      susceptible subjects. However, ethical and practical barriers to such experiments
      are considerable.
FAU - Riedl, Marc A
AU  - Riedl MA
AD  - Department of Allergy and Immunology, University of California-Los Angeles,
      90095, USA. mriedl@mednet.ucla.edu
FAU - Diaz-Sanchez, David
AU  - Diaz-Sanchez D
FAU - Linn, William S
AU  - Linn WS
FAU - Gong, Henry Jr
AU  - Gong H Jr
FAU - Clark, Kenneth W
AU  - Clark KW
FAU - Effros, Richard M
AU  - Effros RM
FAU - Miller, J Wayne
AU  - Miller JW
FAU - Cocker, David R
AU  - Cocker DR
FAU - Berhane, Kiros T
AU  - Berhane KT
CN  - HEI Health Review Committee
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Res Rep Health Eff Inst
JT  - Research report (Health Effects Institute)
JID - 8812230
RN  - 0 (Air Pollutants)
RN  - 0 (Particulate Matter)
RN  - 0 (Vehicle Emissions)
RN  - S7G510RUBH (Nitrogen Dioxide)
SB  - IM
MH  - Adult
MH  - Air Pollutants/analysis/*toxicity
MH  - Air Pollution/*adverse effects/analysis
MH  - Female
MH  - Humans
MH  - Inhalation Exposure/adverse effects
MH  - Male
MH  - Middle Aged
MH  - Nitrogen Dioxide/analysis/toxicity
MH  - Particulate Matter/analysis/*toxicity
MH  - Respiratory Hypersensitivity/*chemically induced
MH  - Saliva/chemistry
MH  - Time Factors
MH  - Vehicle Emissions/analysis/*toxicity
MH  - Young Adult
EDAT- 2012/08/03 06:00
MHDA- 2012/09/05 06:00
CRDT- 2012/08/03 06:00
PHST- 2012/08/03 06:00 [entrez]
PHST- 2012/08/03 06:00 [pubmed]
PHST- 2012/09/05 06:00 [medline]
PST - ppublish
SO  - Res Rep Health Eff Inst. 2012 Feb;(165):5-43; discussion 45-64.


PMID- 22852483
OWN - NLM
STAT- MEDLINE
DCOM- 20120830
LR  - 20151119
IS  - 0040-781X (Print)
IS  - 0040-781X (Linking)
VI  - 180
IP  - 4
DP  - 2012 Jul 23
TI  - The fast-food ethicist.
PG  - 40-4
FAU - Stein, Joel
AU  - Stein J
LA  - eng
PT  - News
PL  - United States
TA  - Time
JT  - Time
JID - 9877130
MH  - Commerce
MH  - *Ethics
MH  - *Fast Foods
MH  - *Food, Organic
MH  - Organizational Case Studies
MH  - United States
EDAT- 2012/08/03 06:00
MHDA- 2012/08/31 06:00
CRDT- 2012/08/03 06:00
PHST- 2012/08/03 06:00 [entrez]
PHST- 2012/08/03 06:00 [pubmed]
PHST- 2012/08/31 06:00 [medline]
PST - ppublish
SO  - Time. 2012 Jul 23;180(4):40-4.


PMID- 22852452
OWN - NLM
STAT- MEDLINE
DCOM- 20120911
LR  - 20120802
IS  - 1477-7266 (Print)
IS  - 1477-7266 (Linking)
VI  - 26
IP  - 3
DP  - 2012
TI  - Social values and health policy: a new international research programme.
PG  - 285-92
AB  - PURPOSE: This editorial aims to outline the context of healthcare
      priority-setting, and summarise each of the other ten papers in this special
      edition. It introduces a new multidisciplinary research programme drawing on
      ethics, philosophy, health economics, political science and health technology
      assessment, out of which the papers in this edition have arisen.
      DESIGN/METHODOLOGY/APPROACH: Key normative concepts are introduced and policy and
      research context provided to frame subsequent papers in the edition. FINDINGS:
      Common challenges of health priority-setting are faced by many countries across
      the world, and a range of social value judgments is in play as resource
      allocation decisions are made. Although the challenges faced by different
      countries are in many ways similar, the way in which social values affect the
      processes and content of priority-setting decisions means that those challenges
      are resolved very differently in a variety of social, political, cultural and
      institutional settings, as subsequent papers in this edition demonstrate. How
      social values affect decision making in this way is the subject of a new
      multi-disciplinary research programme. ORIGINALITY/VALUE: Technical analyses of
      health priority setting are commonplace, but approaching the issues from the
      perspective of social values and conducting comparative analyses across countries
      with very different cultural, social and institutional contexts provides the
      content for a new research agenda.
FAU - Littlejohns, Peter
AU  - Littlejohns P
FAU - Weale, Albert
AU  - Weale A
FAU - Chalkidou, Kalipso
AU  - Chalkidou K
FAU - Faden, Ruth
AU  - Faden R
FAU - Teerawattananon, Yot
AU  - Teerawattananon Y
LA  - eng
PT  - Editorial
PT  - Introductory Journal Article
PL  - England
TA  - J Health Organ Manag
JT  - Journal of health organization and management
JID - 101179473
MH  - *Health Policy
MH  - Humans
MH  - *Internationality
MH  - Research/*trends
MH  - *Social Values
EDAT- 2012/08/03 06:00
MHDA- 2012/09/12 06:00
CRDT- 2012/08/03 06:00
PHST- 2012/08/03 06:00 [entrez]
PHST- 2012/08/03 06:00 [pubmed]
PHST- 2012/09/12 06:00 [medline]
AID - 10.1108/14777261211238945 [doi]
PST - ppublish
SO  - J Health Organ Manag. 2012;26(3):285-92. doi: 10.1108/14777261211238945.


PMID- 22852201
OWN - NLM
STAT- MEDLINE
DCOM- 20120906
LR  - 20120802
IS  - 0883-5381 (Print)
IS  - 0883-5381 (Linking)
VI  - 27
IP  - 4
DP  - 2012 Jul-Aug
TI  - Comparing ethics and compliance programs. Each is unique, but overlaps are key to
      clarifying organizational roles.
PG  - 46, 48-9
FAU - Nelson, William A
AU  - Nelson WA
AD  - Dartmouth Institute for Health Policy and Clinical Practice, Geisel School of
      Medicine, USA. william.a.nelson@dartmouth.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Healthc Exec
JT  - Healthcare executive
JID - 8612808
MH  - *Ethics, Institutional
MH  - *Guideline Adherence
MH  - *Health Facility Administration
MH  - United States
EDAT- 2012/08/03 06:00
MHDA- 2012/09/07 06:00
CRDT- 2012/08/03 06:00
PHST- 2012/08/03 06:00 [entrez]
PHST- 2012/08/03 06:00 [pubmed]
PHST- 2012/09/07 06:00 [medline]
PST - ppublish
SO  - Healthc Exec. 2012 Jul-Aug;27(4):46, 48-9.


PMID- 22852002
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1896-9151 (Electronic)
IS  - 1734-1922 (Linking)
VI  - 8
IP  - 3
DP  - 2012 Jul 4
TI  - A pilot study of circulating PPAR-gamma receptor protein in elderly patients with
      atrial fibrillation.
PG  - 471-6
LID - 10.5114/aoms.2012.29402 [doi]
AB  - INTRODUCTION: The present study aimed to investigate the relationship between
      serum peroxisome proliferator-activated receptor-gamma (PPAR-gamma) protein
      concentration and inflammatory markers in elderly patients with atrial
      fibrillation (AF). MATERIAL AND METHODS: We enrolled a total of 73 elderly
      patients: 45 with AF as the test group and 28 in sinus rhythm as a control group.
      We assayed serum PPAR-gamma receptor protein, high-sensitivity C-reactive protein
      (hs-CRP), interleukin-6 (IL-6), and tumour necrosis factor-alpha (TNF-alpha). The
      study protocol and written informed consent were approved by the Ethics Committee
      of Clinical Research, Peking University First Hospital. RESULTS: The
      concentration of PPAR-gamma receptor protein was lower in AF patients than that
      in the control group (p < 0.01), and the concentrations of hs-CRP, IL-6, and
      TNF-alpha were higher than those in the control group (all p < 0.01). The
      PPAR-gamma level was negatively correlated with hs-CRP, IL-6, and left atrium
      diameter (LAD) level (all p < 0.05). On logistic regression analysis, PPAR-gamma,
      hs-CRP, TNF-alpha and LAD level were associated with AF. CONCLUSIONS: Elderly
      patients with AF show an inflammatory state and atrial remodeling. The PPAR-gamma
      receptor protein concentration is inversely linked with inflammation in AF. As an
      important transcription factor regulating inflammatory gene expression,
      PPAR-gamma may take part in the pathogenesis of AF.
FAU - Lin, Qing
AU  - Lin Q
AD  - Department of Geriatrics, Peking University First Hospital, Beijing, China.
FAU - Jia, Lina
AU  - Jia L
FAU - Sun, Yanshu
AU  - Sun Y
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - Arch Med Sci
JT  - Archives of medical science : AMS
JID - 101258257
PMC - PMC3400903
OTO - NOTNLM
OT  - atrial fibrillation
OT  - inflammation
OT  - peroxisome proliferator-activated receptor-gamma
EDAT- 2012/08/02 06:00
MHDA- 2012/08/02 06:01
CRDT- 2012/08/02 06:00
PHST- 2011/04/12 00:00 [received]
PHST- 2011/10/23 00:00 [revised]
PHST- 2011/11/03 00:00 [accepted]
PHST- 2012/08/02 06:00 [entrez]
PHST- 2012/08/02 06:00 [pubmed]
PHST- 2012/08/02 06:01 [medline]
AID - 10.5114/aoms.2012.29402 [doi]
AID - 18823 [pii]
PST - ppublish
SO  - Arch Med Sci. 2012 Jul 4;8(3):471-6. doi: 10.5114/aoms.2012.29402.


PMID- 22851773
OWN - NLM
STAT- MEDLINE
DCOM- 20121004
LR  - 20211021
IS  - 0008-5286 (Print)
IS  - 0008-5286 (Linking)
VI  - 53
IP  - 2
DP  - 2012 Feb
TI  - An ethicist's commentary on the sale of a veterinary practice to an associate.
PG  - 119-20
FAU - Rollin, Bernard E
AU  - Rollin BE
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Vet J
JT  - The Canadian veterinary journal = La revue veterinaire canadienne
JID - 0004653
SB  - IM
MH  - Animals
MH  - Canada
MH  - Commerce/*ethics
MH  - *Ethics, Professional
MH  - Hospitals, Animal/*economics
MH  - Humans
MH  - Interprofessional Relations/*ethics
MH  - *Veterinary Medicine/ethics
PMC - PMC3258824
EDAT- 2012/08/02 06:00
MHDA- 2012/10/05 06:00
CRDT- 2012/08/02 06:00
PHST- 2012/08/02 06:00 [entrez]
PHST- 2012/08/02 06:00 [pubmed]
PHST- 2012/10/05 06:00 [medline]
PST - ppublish
SO  - Can Vet J. 2012 Feb;53(2):119-20.


PMID- 22851643
OWN - NLM
STAT- MEDLINE
DCOM- 20140423
LR  - 20211021
IS  - 1465-735X (Electronic)
IS  - 0146-8693 (Linking)
VI  - 37
IP  - 10
DP  - 2012 Nov-Dec
TI  - Case study: ethical guidance for pediatric e-health research using examples from 
      pain research with adolescents.
PG  - 1116-26
LID - 10.1093/jpepsy/jss085 [doi]
AB  - OBJECTIVE: The Internet is a frequently used platform for research in pediatric
      and health psychology. However, there is little pragmatic guidance as to ethical 
      best practice of this research. The absence of guidance is particularly prominent
      for online research with children. Our objective is to outline ethical issues in 
      e-health research with children and adolescents using two exemplar studies in
      pediatric pain research. METHODS: The first study is an asynchronous message
      board discussion amongst teenagers with pain who are frequent internet users.The 
      second study is a web-based behavioral intervention for the management of
      adolescent pain. RESULTS: Each exemplar study is discussed in the context of
      specific ethical considerations related to recruitment, informed consent and
      debriefing, privacy and confidentiality, and participant safety. Ethical issues
      regarding the evaluation of online psychological interventions are also
      discussed. CONCLUSIONS: Guidance on optimal ethical practice in e-health research
      is summarized.
FAU - Henderson, Ellen M
AU  - Henderson EM
AD  - Centre for Pain Research, The University of Bath, Bath, BA2 7AY, UK.
FAU - Law, Emily F
AU  - Law EF
FAU - Palermo, Tonya M
AU  - Palermo TM
FAU - Eccleston, Christopher
AU  - Eccleston C
LA  - eng
GR  - K24 HD060068/HD/NICHD NIH HHS/United States
GR  - R01 HD062538/HD/NICHD NIH HHS/United States
GR  - R01HD062538/HD/NICHD NIH HHS/United States
GR  - K24HD060068/HD/NICHD NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120731
PL  - United States
TA  - J Pediatr Psychol
JT  - Journal of pediatric psychology
JID - 7801773
SB  - IM
MH  - Adolescent
MH  - Biomedical Research/*ethics/methods
MH  - Cognitive Behavioral Therapy/*ethics/methods
MH  - Focus Groups
MH  - Humans
MH  - Internet/*ethics/statistics & numerical data
MH  - Pain/psychology/*rehabilitation
MH  - Pediatrics/*ethics
MH  - Telemedicine/*ethics
PMC - PMC3529561
EDAT- 2012/08/02 06:00
MHDA- 2014/04/24 06:00
CRDT- 2012/08/02 06:00
PHST- 2012/08/02 06:00 [entrez]
PHST- 2012/08/02 06:00 [pubmed]
PHST- 2014/04/24 06:00 [medline]
AID - jss085 [pii]
AID - 10.1093/jpepsy/jss085 [doi]
PST - ppublish
SO  - J Pediatr Psychol. 2012 Nov-Dec;37(10):1116-26. doi: 10.1093/jpepsy/jss085. Epub 
      2012 Jul 31.


PMID- 22851401
OWN - NLM
STAT- MEDLINE
DCOM- 20121121
LR  - 20181023
IS  - 0047-262X (Print)
VI  - 59
IP  - 4
DP  - 2012 Aug
TI  - [Clinical ethic dilemmas and difficulties in reporting child abuse].
PG  - 105-10
LID - 10.6224/JN.59.3.105 [doi]
LID - JN.59.3.105 [pii]
AB  - The number of reported cases of child abuse has been rising steadily in Taiwan.
      Although child abuse reporting is mandatory for healthcare professionals,
      Taiwan-specific social norms and traditional cultural values make the decision to
      report such abuse more complex and difficult. We used Jonsen's four topics method
      to examine a suspected case of child abuse and to analyze its associated dilemmas
      and ethical difficulties. We then discussed the identified conflicts among the
      three aspects of cultural values, legal obligations, and personal values.
      Findings indicate that healthcare professionals experience dilemmas among these
      three aspects. Reporting suspected child abuse appears the best resolution after 
      considering and balancing the principles of non-malfeasance, beneficence,
      fidelity and follow-up care. Once reported, resources can be provided to the
      affected child and his / her family. This case analysis provides a reference for 
      healthcare professionals to deal with child abuse cases.
FAU - Huang, Tzu-Yi
AU  - Huang TY
AD  - Department of Nursing, Chi Mei Medical Center, ROC.
FAU - Chiang, Wan-Lin
AU  - Chiang WL
FAU - Su, Yi-Fei
AU  - Su YF
FAU - Feng, Jui-Ying
AU  - Feng JY
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China (Republic : 1949- )
TA  - Hu Li Za Zhi
JT  - Hu li za zhi The journal of nursing
JID - 0073267
SB  - IM
MH  - Child
MH  - *Child Abuse
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Mandatory Reporting/*ethics
MH  - Taiwan
EDAT- 2012/08/02 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/08/02 06:00
PHST- 2012/08/02 06:00 [entrez]
PHST- 2012/08/02 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.6224/JN.59.3.105 [doi]
PST - ppublish
SO  - Hu Li Za Zhi. 2012 Aug;59(4):105-10. doi: 10.6224/JN.59.3.105.


PMID- 22851382
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141103
LR  - 20220630
IS  - 1467-9280 (Electronic)
IS  - 0956-7976 (Linking)
VI  - 23
IP  - 8
DP  - 2012 Aug 1
TI  - Retraction of "Construing collective concerns: increasing cooperation by
      broadening construals in social dilemmas".
PG  - 949
LID - 10.1177/0956797612457151 [doi]
AB  - The following article has been retracted by the Editor and publishers of
      Psychological Science at the request of the lead author, Lawrence J. Sanna:
      Sanna, L. J., Chang, E. C., Parks, C. D., & Kennedy, L. A. (2009). Construing
      collective concerns: Increasing cooperation by broadening construals in social
      dilemmas. Psychological Science, 20, 1319-1321.
      doi:10.1111/j.1467-9280.2009.02458.x In a letter to the Editor (Eric Eich), Dr.
      Sanna wrote: The data reported in this article are invalid and should not be
      considered part of the scientific literature. The responsibility for this problem
      rests solely with the first author, Lawrence J. Sanna. Coauthors Edward C. Chang,
      Craig D. Parks, and Lindsay A. Kennedy are in no way responsible for this
      problem. In response, the Editor noted that Psychological Science follows the
      retraction guidelines developed by the Committee on Publication Ethics (COPE).
      Dr. Sanna was urged to follow these guidelines carefully in drafting a retraction
      notice, particularly with respect to stating the reasons for the retraction, to
      distinguish misconduct from honest error. To assist Dr. Sanna with this task, the
      Editor provided Dr. Sanna with a copy of the COPE guidelines
      (http://publicationethics.org/resources/guidelines) and a link to a retraction
      notice that was published in Psychological Science last year. This notice was
      considered a "model" by Retraction Watch, and Dr. Sanna was advised that, in
      keeping with this notice, he "must specify clearly the reasons for the retraction
      in such language that all of your coauthors agree to it." While awaiting Dr.
      Sanna's reply, the Editor sought to contact Dr. Sanna's three coauthors. Although
      one coauthor was aware of Dr. Sanna's request to retract the 2009 Psychological
      Science article, the other two were not. All of the coauthors have agreed to
      retraction of the article, and each has received a copy of this notice. Dr. Sanna
      replied by noting with regret that "research errors" have made it necessary for
      him to request retraction. The letter concluded with the following: "At the
      direction of legal counsel, I am unable to say anything further than that
      contained in my previous letter at this time." Because it is unclear when, if
      ever, details on these research errors will be forthcoming, the Editor owes it to
      the journal's readership to retract the article now, even though this notice does
      not reflect COPE guidelines or journal policy.
LA  - eng
PT  - Retraction of Publication
PT  - Retracted Publication
DEP - 20120730
PL  - United States
TA  - Psychol Sci
JT  - Psychological science
JID - 9007542
ROF - Sanna LJ, Chang EC, Parks CD, Kennedy LA. Psychol Sci. 2009 Nov;20(11):1319-21.
      PMID: 19845890
RIN - Technol Health Care. 2022;30(3):767. PMID: 35404297
EDAT- 2012/08/02 06:00
MHDA- 2014/11/05 06:00
CRDT- 2012/08/02 06:00
PHST- 2012/08/02 06:00 [entrez]
PHST- 2012/08/02 06:00 [pubmed]
PHST- 2014/11/05 06:00 [medline]
AID - 0956797612457151 [pii]
AID - 10.1177/0956797612457151 [doi]
PST - ppublish
SO  - Psychol Sci. 2012 Aug 1;23(8):949. doi: 10.1177/0956797612457151. Epub 2012 Jul
      30.


PMID- 22851302
OWN - NLM
STAT- MEDLINE
DCOM- 20130503
LR  - 20220408
IS  - 2629-3277 (Electronic)
IS  - 2629-3277 (Linking)
VI  - 8
IP  - 4
DP  - 2012 Dec
TI  - The evolution of policy issues in stem cell research: an international survey.
PG  - 1037-42
LID - 10.1007/s12015-012-9404-5 [doi]
AB  - Stem cell research remains a tremendously promising yet controversial field of
      study. It continues to attract considerable public interest and generate
      discussion and debate. However, while the high profile of this field has endured,
      the tone and nature of the discourse that drives this profile appears to be
      changing. In order to get a better sense of how these potential shifts are
      perceived by individuals directly embedded in the field, we conducted an
      international internet survey of members of the stem cell research community. Our
      participants included individuals publishing on both scientific and ethical,
      legal and social issues topics. We explored the degree to which participants
      perceived that key policy issues were becoming more or less contentious over
      time. We queried views regarding the effect of regulatory frameworks on emerging 
      stem cell research technologies and the extent to which participants experience
      pressure related to clinical translation. We also explored participants'
      relationships with industry, experience with patents and perceptions regarding
      the emphasis placed on the potential economic benefits of stem cell research. Our
      results suggest that while traditional debates such as those surrounding the
      moral status of the embryo remain, other issues more closely associated with
      clinical translation and commercialization are perceived as becoming increasingly
      contentious. This survey provides useful insight into the perspectives of a
      sample of active researchers working in countries around the world as well as an 
      opportunity to reflect on the likely direction of future stem cell policy
      debates.
FAU - Caulfield, Timothy
AU  - Caulfield T
AD  - Health Law and Science Policy Group, University of Alberta, Edmonton, AB, Canada.
      tcaulfld@law.ualberta.ca
FAU - Rachul, Christen
AU  - Rachul C
FAU - Zarzeczny, Amy
AU  - Zarzeczny A
LA  - eng
GR  - CSC-105367/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Stem Cell Rev Rep
JT  - Stem cell reviews and reports
JID - 101752767
SB  - IM
MH  - Animals
MH  - Bioethical Issues/*legislation & jurisprudence/*standards
MH  - *Bioethics
MH  - *Biomedical Research/economics/legislation & jurisprudence/organization &
      administration/standards
MH  - Data Collection
MH  - Humans
MH  - *Stem Cells
EDAT- 2012/08/02 06:00
MHDA- 2013/05/04 06:00
CRDT- 2012/08/02 06:00
PHST- 2012/08/02 06:00 [entrez]
PHST- 2012/08/02 06:00 [pubmed]
PHST- 2013/05/04 06:00 [medline]
AID - 10.1007/s12015-012-9404-5 [doi]
PST - ppublish
SO  - Stem Cell Rev Rep. 2012 Dec;8(4):1037-42. doi: 10.1007/s12015-012-9404-5.


PMID- 22850465
OWN - NLM
STAT- MEDLINE
DCOM- 20121015
LR  - 20191112
IS  - 2300-732X (Electronic)
IS  - 1642-431X (Linking)
VI  - 12
IP  - 2
DP  - 2012 Jul
TI  - The rat as an animal model for fetoplacental development: a reappraisal of the
      post-implantation period.
PG  - 97-118
AB  - Following implantation in rodents, the uterine stromal fibroblasts differentiate 
      into densely packed decidual cells. This process, called decidualization, is
      well-orchestrated and progresses both antimesometrially and mesometrially,
      creating two regions with distinctive cellular morphologies. In addition,
      subsequent placental development is dependent on the invasion of the trophoblast,
      the process intimately linked to the endometrial tissue remodelling and depending
      largely on the environment created by the decidua; this phenomenon is crucial for
      the establishment and maintenance of pregnancy. The key mechanisms underlying the
      maternal tissue remodelling and trophoblast invasion remain poorly understood.
      The rat, just like human beings, exhibits a highly invasive type of placental
      development, the haemochorial placentation. For obvious ethical reasons, the
      studies of endometrial tissue remodelling throughout pregnancy in humans are
      greatly limited. Although the rat differs somewhat from humans with regards to
      the implantation process, it is an appropriate model for studying the mechanisms 
      of decidualization as well as subsequent remodelling of the uterine tissues and
      fetoplacental development. As decidual remodelling is very closely linked to
      placentation and the maternal-fetal interactions in the rat show several
      important similarities to human placentation, the morphological alterations
      occurring during the post-implantation period in the rat have been addressed in
      the present review.
FAU - Fonseca, Bruno M
AU  - Fonseca BM
AD  - Laboratory of Biochemistry, Department of Biologcal Sciences, Faculty of
      Pharmacy, University of Porto and Institute for Molecular and Cell Biology
      (IBMC), Porto, Portugal.
FAU - Correia-da-Silva, Georgina
AU  - Correia-da-Silva G
FAU - Teixeira, Natercia A
AU  - Teixeira NA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Poland
TA  - Reprod Biol
JT  - Reproductive biology
JID - 101160559
SB  - IM
MH  - Animals
MH  - Decidua/*physiology
MH  - Embryo Implantation/*physiology
MH  - Embryonic Development/*physiology
MH  - Female
MH  - Fetal Development/*physiology
MH  - Humans
MH  - *Models, Animal
MH  - Placentation/*physiology
MH  - Pregnancy
MH  - Rats
MH  - Trophoblasts/*physiology
EDAT- 2012/08/02 06:00
MHDA- 2012/10/16 06:00
CRDT- 2012/08/02 06:00
PHST- 2012/08/02 06:00 [entrez]
PHST- 2012/08/02 06:00 [pubmed]
PHST- 2012/10/16 06:00 [medline]
AID - S1642-431X(12)60080-1 [pii]
AID - 10.1016/s1642-431x(12)60080-1 [doi]
PST - ppublish
SO  - Reprod Biol. 2012 Jul;12(2):97-118. doi: 10.1016/s1642-431x(12)60080-1.


PMID- 22850353
OWN - NLM
STAT- MEDLINE
DCOM- 20130118
LR  - 20161018
IS  - 1536-5948 (Electronic)
IS  - 1076-2752 (Linking)
VI  - 54
IP  - 8
DP  - 2012 Aug
TI  - Barriers and facilitators to implementation of an occupational health guideline
      aimed at preventing weight gain among employees in the Netherlands.
PG  - 954-60
AB  - OBJECTIVE: To assess barriers and facilitators to implementation of an
      occupational health guideline aimed at preventing weight gain. METHODS: Barriers 
      and facilitators to implementation were assessed among 14 occupational physicians
      (OPs) and employers and analyzed following a systematic approach using Atlas.ti. 
      RESULTS: Barriers and facilitators mentioned by OPs and employers were related to
      the sociopolitical context, organization, OP, and guideline. Recommendations
      include the formation of a linkage group, collaboration with other experts,
      formation of peer support groups, and communicating benefits of investments,
      expectations, and ethical considerations. Results of this study recommend
      incorporating these barriers and facilitators in the guideline, including
      strategies about how to overcome barriers and stimulate facilitators.
      CONCLUSIONS: The identified barriers and facilitators can be used to increase the
      chance of successful implementation of the final guideline into occupational
      health practices throughout the Netherlands.
FAU - Verweij, Lisanne M
AU  - Verweij LM
AD  - Department of Public and Occupational Health and EMGO Institute for Health and
      Care Research, VU University Medical Center, Amsterdam, the Netherlands.
FAU - Proper, Karin I
AU  - Proper KI
FAU - Leffelaar, Evelien R
AU  - Leffelaar ER
FAU - Weel, Andre N H
AU  - Weel AN
FAU - Nauta, Arnolda P
AU  - Nauta AP
FAU - Hulshof, Carel T J
AU  - Hulshof CT
FAU - van Mechelen, Willem
AU  - van Mechelen W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Occup Environ Med
JT  - Journal of occupational and environmental medicine
JID - 9504688
SB  - IM
MH  - Adult
MH  - Female
MH  - Focus Groups/methods
MH  - Guideline Adherence/ethics/organization & administration
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Netherlands
MH  - Occupational Health Services/*standards
MH  - Overweight/*prevention & control
MH  - *Practice Guidelines as Topic
MH  - Weight Gain/*physiology
MH  - Workplace/organization & administration/psychology
EDAT- 2012/08/02 06:00
MHDA- 2013/01/19 06:00
CRDT- 2012/08/02 06:00
PHST- 2012/08/02 06:00 [entrez]
PHST- 2012/08/02 06:00 [pubmed]
PHST- 2013/01/19 06:00 [medline]
AID - 10.1097/JOM.0b013e3182511c9f [doi]
PST - ppublish
SO  - J Occup Environ Med. 2012 Aug;54(8):954-60. doi: 10.1097/JOM.0b013e3182511c9f.


PMID- 22850221
OWN - NLM
STAT- MEDLINE
DCOM- 20130111
LR  - 20220318
IS  - 1471-6771 (Electronic)
IS  - 0007-0912 (Linking)
VI  - 109
IP  - 5
DP  - 2012 Nov
TI  - Do technical skills correlate with non-technical skills in crisis resource
      management: a simulation study.
PG  - 723-8
LID - 10.1093/bja/aes256 [doi]
AB  - BACKGROUND: Both technical skills (TS) and non-technical skills (NTS) are key to 
      ensuring patient safety in acute care practice and effective crisis management.
      These skills are often taught and assessed separately. We hypothesized that TS
      and NTS are not independent of each other, and we aimed to evaluate the
      relationship between TS and NTS during a simulated intraoperative crisis
      scenario. METHODS: This study was a retrospective analysis of performances from a
      previously published work. After institutional ethics approval, 50
      anaesthesiology residents managed a simulated crisis scenario of an
      intraoperative cardiac arrest secondary to a malignant arrhythmia. We used a
      modified Delphi approach to design a TS checklist, specific for the management of
      a malignant arrhythmia requiring defibrillation. All scenarios were recorded.
      Each performance was analysed by four independent experts. For each performance, 
      two experts independently rated the technical performance using the TS checklist,
      and two other experts independently rated NTS using the Anaesthetists'
      Non-Technical Skills score. RESULTS: TS and NTS were significantly correlated to 
      each other (r=0.45, P<0.05). CONCLUSIONS: During a simulated 5 min resuscitation 
      requiring crisis resource management, our results indicate that TS and NTS are
      related to one another. This research provides the basis for future studies
      evaluating the nature of this relationship, the influence of NTS training on the 
      performance of TS, and to determine whether NTS are generic and transferrable
      between crises that require different TS.
FAU - Riem, N
AU  - Riem N
AD  - Department of Anaesthesiology, Kantonsspital Liestal, University of Basel,
      Rheinstrasse 26, Liestal, Switzerland. nriem@aol.com
FAU - Boet, S
AU  - Boet S
FAU - Bould, M D
AU  - Bould MD
FAU - Tavares, W
AU  - Tavares W
FAU - Naik, V N
AU  - Naik VN
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120731
PL  - England
TA  - Br J Anaesth
JT  - British journal of anaesthesia
JID - 0372541
SB  - IM
MH  - Anesthesiology/*methods
MH  - Arrhythmias, Cardiac/complications
MH  - Cardiopulmonary Resuscitation/*methods
MH  - Clinical Competence/*statistics & numerical data
MH  - Emergencies
MH  - Female
MH  - Heart Arrest/etiology/therapy
MH  - Humans
MH  - Intraoperative Complications/therapy
MH  - Male
MH  - *Models, Organizational
MH  - Observer Variation
MH  - Patient Safety/*statistics & numerical data
MH  - *Patient Simulation
MH  - Resource Allocation/*organization & administration
MH  - Retrospective Studies
PMC - PMC3470444
EDAT- 2012/08/02 06:00
MHDA- 2013/01/12 06:00
CRDT- 2012/08/02 06:00
PHST- 2012/08/02 06:00 [entrez]
PHST- 2012/08/02 06:00 [pubmed]
PHST- 2013/01/12 06:00 [medline]
AID - S0007-0912(17)31633-1 [pii]
AID - 10.1093/bja/aes256 [doi]
PST - ppublish
SO  - Br J Anaesth. 2012 Nov;109(5):723-8. doi: 10.1093/bja/aes256. Epub 2012 Jul 31.


PMID- 22850167
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20220409
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 4
DP  - 2012
TI  - Prevalence of anal incontinence among Norwegian women: a cross-sectional study.
LID - 10.1136/bmjopen-2012-001257 [doi]
LID - e001257 [pii]
AB  - OBJECTIVE: Anal incontinence (AI) is a symptom associated with age, bowel
      symptoms and obstetric injuries. Primary aim of the study was to establish the
      prevalence of AI among women and secondarily to evaluate the impact on daily life
      and conditions associated with AI. DESIGN: A cross-sectional study. SETTING:
      Participants attended research stations located in different parts of
      Nord-Trondelag county, Norway. Data were collected through interviews,
      questionnaires and clinical examinations. PARTICIPANTS: In total, 40 955
      community-dwelling women aged 30 years and older were invited. A total of 25 037 
      women participated, giving a participation rate of 61.1%. PRIMARY AND SECONDARY
      OUTCOME MEASURES: Fecal incontinence and flatal incontinence was defined as
      involuntary loss of feces and flatus weekly or more, respectively. AI was defined
      as the involuntary loss of feces and/or flatus weekly or more. Urgency was
      defined as the inability to defer defecation for 15 min. Statistical methods
      included prevalence estimates and logistic regression analysis. RESULTS:
      Questions about AI were completed by 20 391 (82.4%) women. Among the 20 391
      women, AI was reported by 19.1% (95% CI 18.6% to 19.7%) and fecal incontinence
      was reported by 3.0% (95% CI 2.8% to 3.2%). Urgency was experienced by 2586 women
      (12.7%, 95% CI 12.2 to 13.1). Impact on daily life was stated by 794 (26.0%, 95% 
      CI 24.4 to 27.5) women with AI. In bivariate age-adjusted analysis of AI, OR and 
      CI for urgency (OR 3.19, 95% CI 2.92 to 3.49) and diarrhoea (OR 3.81, 95% CI 3.32
      to 4.38) revealed strongest associations with AI. CONCLUSIONS: AI affects one in 
      five women older than 30 years. Strongest associated symptoms are urgency and
      diarrhoea. TRIAL REGISTRATION NUMBER: The study was approved by the Regional
      Committee for Medical and Health Research Ethics (No. 2009/1214) and followed the
      Declaration of Helsinki.
FAU - Rommen, Kathrine
AU  - Rommen K
AD  - Department of Public Health and General Practice, Norwegian University of Science
      and Technology, Trondheim, Norway.
FAU - Schei, Berit
AU  - Schei B
FAU - Rydning, Astrid
AU  - Rydning A
FAU - H Sultan, Abdul
AU  - H Sultan A
FAU - Morkved, Siv
AU  - Morkved S
LA  - eng
PT  - Journal Article
DEP - 20120730
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
EIN - BMJ Open. 2012 Sep 27;2(5):null. PMID: 23019209
PMC - PMC4400729
EDAT- 2012/08/02 06:00
MHDA- 2012/08/02 06:01
CRDT- 2012/08/02 06:00
PHST- 2012/08/02 06:00 [entrez]
PHST- 2012/08/02 06:00 [pubmed]
PHST- 2012/08/02 06:01 [medline]
AID - bmjopen-2012-001257 [pii]
AID - 10.1136/bmjopen-2012-001257 [doi]
PST - epublish
SO  - BMJ Open. 2012 Jul 30;2(4). pii: bmjopen-2012-001257. doi:
      10.1136/bmjopen-2012-001257. Print 2012.


PMID- 22850148
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20120801
IS  - 1556-2654 (Electronic)
IS  - 1556-2646 (Linking)
VI  - 7
IP  - 3
DP  - 2012 Jul
TI  - Educational advantage.
PG  - 93
LID - 10.1525/jer.2012.7.3.93 [doi]
AB  - Emerging issues in human research challenge us to think outside of the box. The
      first three papers in this issue provide such challenges. New ethical issues
      arise in connection with research on the human microbiome, sham surgery, and the 
      use of psychotherapy in research interventions in tribal cultures in Kenya.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Biomedical Research/*ethics
MH  - *Ethics, Research
MH  - Humans
EDAT- 2012/08/02 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/08/02 06:00
PHST- 2012/08/02 06:00 [entrez]
PHST- 2012/08/02 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1525/jer.2012.7.3.93 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2012 Jul;7(3):93. doi: 10.1525/jer.2012.7.3.93.


PMID- 22850144
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20120801
IS  - 1556-2654 (Electronic)
IS  - 1556-2646 (Linking)
VI  - 7
IP  - 3
DP  - 2012 Jul
TI  - Case-based ethics education: the impact of cause complexity and outcome
      favorability on ethicality.
PG  - 63-77
LID - 10.1525/jer.2012.7.3.63 [doi]
AB  - Case-based learning has been used across multiple disciplines, including ethics
      education, as an effective instructional tool. However, the value of case-based
      learning in ethics education has varied widely regarding case quality. Case
      content may significantly impact the ability of case-based ethics education to
      promote knowledge acquisition and knowledge transfer to future situations
      requiring ethical decision-making. This study examined two critical areas of
      ethical case content--causes and outcomes. Complexity of described causes and
      outcome favorability were manipulated in two ethical cases used during an ethics 
      education course. Results suggest that including information in case studies
      reflecting clear, simple key causes and negative outcomes results in better
      ethical sensemaking and ethical decision-making. Implications regarding case
      content and case-based ethics education are explored.
FAU - Johnson, James F
AU  - Johnson JF
AD  - The University of Oklahoma, Norman, OK, USA. johnsonjf@ou.edu
FAU - Bagdasarov, Zhanna
AU  - Bagdasarov Z
FAU - Connelly, Shane
AU  - Connelly S
FAU - Harkrider, Lauren
AU  - Harkrider L
FAU - Devenport, Lynn D
AU  - Devenport LD
FAU - Mumford, Michael D
AU  - Mumford MD
FAU - Thiel, Chase E
AU  - Thiel CE
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Adult
MH  - *Casuistry
MH  - Decision Making/*ethics
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - *Learning
MH  - Male
MH  - Teaching/*methods
EDAT- 2012/08/02 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/08/02 06:00
PHST- 2012/08/02 06:00 [entrez]
PHST- 2012/08/02 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1525/jer.2012.7.3.63 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2012 Jul;7(3):63-77. doi: 10.1525/jer.2012.7.3.63.


PMID- 22850142
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20220316
IS  - 1556-2654 (Electronic)
IS  - 1556-2646 (Linking)
VI  - 7
IP  - 3
DP  - 2012 Jul
TI  - Human research ethics committees: examining their roles and practices.
PG  - 38-49
LID - 10.1525/jer.2012.7.3.38 [doi]
AB  - Considerable time and resources are invested in the ethics review process. We
      present qualitative data on how human research ethics committee members and
      health researchers perceive the role and function of the committee. The findings 
      are based on interviews with 34 Australian ethics committee members and 54 health
      researchers. Although all participants agreed that the primary role of the ethics
      committee was to protect participants, there was disagreement regarding the
      additional roles undertaken by committees. Of particular concern were the
      perceptions from some ethics committee members and researchers that ethics
      committees were working to protect the institution's interests, as well as being 
      overprotective toward research participants. This has the potential to lead to
      poor relations and mistrust between ethics committees and researchers.
FAU - Guillemin, Marilys
AU  - Guillemin M
AD  - University of Melbourne, Australia. m.guillemin@unimelb.edu.au
FAU - Gillam, Lynn
AU  - Gillam L
FAU - Rosenthal, Doreen
AU  - Rosenthal D
FAU - Bolitho, Annie
AU  - Bolitho A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Attitude to Health
MH  - Australia
MH  - Biomedical Research/*ethics
MH  - Committee Membership
MH  - *Ethical Review
MH  - Ethics Committees, Research/*ethics
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Interviews as Topic
MH  - Perception
MH  - Professional Role
MH  - Qualitative Research
MH  - Research Personnel
MH  - Trust
EDAT- 2012/08/02 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/08/02 06:00
PHST- 2012/08/02 06:00 [entrez]
PHST- 2012/08/02 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1525/jer.2012.7.3.38 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2012 Jul;7(3):38-49. doi: 10.1525/jer.2012.7.3.38.


PMID- 22850141
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20211021
IS  - 1556-2654 (Electronic)
IS  - 1556-2646 (Linking)
VI  - 7
IP  - 3
DP  - 2012 Jul
TI  - Ethical issues in a stage 1 cognitive-behavioral therapy feasibility study and
      trial to reduce alcohol use among HIV-infected outpatients in western Kenya.
PG  - 29-37
LID - 10.1525/jer.2012.7.3.29 [doi]
AB  - Epidemics of both HIV/AIDS and alcohol abuse in sub-Saharan Africa have spurred
      the conduct of local behavioral therapy trials for these problems, but the
      ethical issues involved in these trials have not been fully examined. In this
      paper, we discuss ethical issues that emerged during the conduct of a behavioral 
      intervention adaptation and trial using cognitive-behavioral therapy to reduce
      alcohol use among HIV-infected outpatients in Eldoret, Kenya. The study was
      performed within our multinational collaboration, the USAID-Academic Model
      Providing Access to Healthcare Partnership. We discuss relevant ethical
      considerations and how we addressed them.
FAU - Papas, Rebecca K
AU  - Papas RK
AD  - Brown University School of Medicine, Providence, RI, USA. Rebecca_Papas@brown.edu
FAU - Gakinya, Benson N
AU  - Gakinya BN
FAU - Baliddawa, Joyce B
AU  - Baliddawa JB
FAU - Martino, Steve
AU  - Martino S
FAU - Bryant, Kendall J
AU  - Bryant KJ
FAU - Meslin, Eric M
AU  - Meslin EM
FAU - Sidle, John E
AU  - Sidle JE
LA  - eng
GR  - R21 AA016884/AA/NIAAA NIH HHS/United States
GR  - P50 DA009241/DA/NIDA NIH HHS/United States
GR  - R25 TW006070/TW/FIC NIH HHS/United States
GR  - R21AA016884/AA/NIAAA NIH HHS/United States
GR  - P50DA09241/DA/NIDA NIH HHS/United States
GR  - R01AA020805/AA/NIAAA NIH HHS/United States
GR  - R01 AA020805/AA/NIAAA NIH HHS/United States
GR  - R25TW008183/TW/FIC NIH HHS/United States
PT  - Clinical Trial, Phase I
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Alcohol Drinking/epidemiology/*prevention & control
MH  - Alcoholism/complications/epidemiology/*therapy
MH  - Biomedical Research/*ethics
MH  - Clinical Trials, Phase I as Topic/*ethics
MH  - *Cognitive Behavioral Therapy
MH  - Epidemics
MH  - *Ethics, Research
MH  - Female
MH  - HIV Infections/complications/epidemiology/*therapy
MH  - Humans
MH  - International Cooperation
MH  - Kenya
MH  - Male
MH  - Outpatients
PMC - PMC3690819
MID - NIHMS474241
EDAT- 2012/08/02 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/08/02 06:00
PHST- 2012/08/02 06:00 [entrez]
PHST- 2012/08/02 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1525/jer.2012.7.3.29 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2012 Jul;7(3):29-37. doi: 10.1525/jer.2012.7.3.29.


PMID- 22850140
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20211021
IS  - 1556-2654 (Electronic)
IS  - 1556-2646 (Linking)
VI  - 7
IP  - 3
DP  - 2012 Jul
TI  - Sham surgery trial controls: perspectives of patients and their relatives.
PG  - 15-28
LID - 10.1525/jer.2012.7.3.15 [doi]
AB  - This study reports on qualitative research conducted in the UK with people with
      Parkinson's Disease and their relatives on the subject of "sham surgery." It
      explores attitudes toward sham surgery and reasoning about hypothetical
      participation in a sham-controlled trial. Results showed that attitudes toward
      sham surgery may not necessarily predict trial participation behavior. A small
      majority of interviewees deemed sham surgery ethically acceptable with certain
      provisos, but hypothetical participation was driven primarily by disease severity
      and a lack of standard treatment options, with a preference for receiving the
      real surgery over sham. Ethical implications for patient equipoise and the
      autonomy of patients' research participation decisions are discussed.
FAU - Swift, Teresa L
AU  - Swift TL
AD  - University of Bristol, UK. teresa.swift@blueyonder.co.uk
LA  - eng
GR  - 068919/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
RN  - 0 (Placebos)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Attitude to Health
MH  - Controlled Clinical Trials as Topic/*ethics
MH  - *Ethics, Research
MH  - Female
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Middle Aged
MH  - Parkinson Disease/*surgery
MH  - Personal Autonomy
MH  - *Placebos
MH  - Qualitative Research
MH  - *Research Design
MH  - *Research Subjects
MH  - Severity of Illness Index
MH  - United Kingdom
PMC - PMC3526366
MID - EMS50790
OID - NLM: EMS50790
EDAT- 2012/08/02 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/08/02 06:00
PHST- 2012/08/02 06:00 [entrez]
PHST- 2012/08/02 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1525/jer.2012.7.3.15 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2012 Jul;7(3):15-28. doi: 10.1525/jer.2012.7.3.15.


PMID- 22850139
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20211021
IS  - 1556-2654 (Electronic)
IS  - 1556-2646 (Linking)
VI  - 7
IP  - 3
DP  - 2012 Jul
TI  - Perspectives on human microbiome research ethics.
PG  - 1-14
LID - 10.1525/jer.2012.7.3.1 [doi]
AB  - Study of ethical, legal, and social implications (ELSI) of human microbiome
      research has been integral to the Human Microbiome Project (HMP). This study
      explores core ELSI issues that arose during the first phase of the HMP from the
      perspective of individuals involved in the research. We conducted semi-structured
      in-depth interviews with investigators and NIH employees ("investigators")
      involved in the HMP, and with individuals recruited to participate in the HMP
      Healthy Cohort Study at Baylor College of Medicine ("recruits"). We report
      findings related to three major ELSI issues: informed consent, data sharing, and 
      return of results. Our findings demonstrate that investigators and recruits were 
      similarly sensitive to these issues yet generally comfortable with study design
      in light of current knowledge about the microbiome.
FAU - McGuire, Amy L
AU  - McGuire AL
AD  - Baylor College of Medicine, Houston, TX, USA. amcguire@bcm.edu
FAU - Achenbaum, Laura S
AU  - Achenbaum LS
FAU - Whitney, Simon N
AU  - Whitney SN
FAU - Slashinski, Melody J
AU  - Slashinski MJ
FAU - Versalovic, James
AU  - Versalovic J
FAU - Keitel, Wendy A
AU  - Keitel WA
FAU - McCurdy, Sheryl A
AU  - McCurdy SA
LA  - eng
GR  - R01 HG004853/HG/NHGRI NIH HHS/United States
GR  - R01HG004853/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Empir Res Hum Res Ethics
JT  - Journal of empirical research on human research ethics : JERHRE
JID - 101273949
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Ethics, Research
MH  - Female
MH  - Humans
MH  - Information Dissemination
MH  - Informed Consent
MH  - Interviews as Topic
MH  - Male
MH  - *Metagenome
MH  - Metagenomics/*ethics/legislation & jurisprudence
MH  - Middle Aged
MH  - National Institutes of Health (U.S.)
MH  - Research Personnel
MH  - Research Subjects
MH  - United States
PMC - PMC4065416
MID - NIHMS569635
EDAT- 2012/08/02 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/08/02 06:00
PHST- 2012/08/02 06:00 [entrez]
PHST- 2012/08/02 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1525/jer.2012.7.3.1 [doi]
PST - ppublish
SO  - J Empir Res Hum Res Ethics. 2012 Jul;7(3):1-14. doi: 10.1525/jer.2012.7.3.1.


PMID- 22850095
OWN - NLM
STAT- MEDLINE
DCOM- 20130103
LR  - 20120801
IS  - 0040-5957 (Print)
IS  - 0040-5957 (Linking)
VI  - 67
IP  - 2
DP  - 2012 Mar-Apr
TI  - [The adoption of Jarde law modifies the legal framework of clinical research in
      France].
PG  - 77-87
LID - 10.2515/therapie/2012022 [doi]
AB  - The Jarde law is adopted further to the Public Health Act No. 2004-806 which
      transposed into French law the Directive 2001/20/EC on clinical trials of
      medicinal products, made effective by the implementing Decree 2006-477 of April
      26, 2006. The main novelty introduced by the Jarde law is to unify all "research 
      organized and practiced on human beings for the development of biological or
      medical knowledge" and to facilitate its effective conduct, without however
      excluding from the scope of the law routine care and non-interventional research.
      The favorable opinion of the French Ethical Research Committee (comite de
      protection des personnes or "CCP") will now be required before launching any
      research on human beings, after validation of the risk/benefit ratio of said
      research. Applicable requirements and procedures - including information and
      consent - are adapted to each category of clinical research. New provisions are
      adopted to address special situations, previously forgotten. Finally, if Ethics
      committees were up until now freely chosen, they will, in two years' time, be
      randomly assigned. Thus, the Jarde law amends substantially the legal framework
      of clinical research in France. The question is whether these new national
      provisions will be compatible with those from the next revision of the so called 
      "clinical trials" directive 2001/20/EC. In any case, the Jarde law will only come
      into force when all required implementing measures have been adopted.
CI  - (c) 2012 Societe Francaise de Pharmacologie et de Therapeutique.
FAU - Maillols-Perroy, Anne-Catherine
AU  - Maillols-Perroy AC
AD  - Cabinet Intuity, Paris, France. anne-catherine.perroy@univ-lille2.fr
FAU - Tillet, Yves
AU  - Tillet Y
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - L'adoption de la loi Jarde modifie l'encadrement juridique de la recherche
      clinique en France.
DEP - 20120802
PL  - France
TA  - Therapie
JT  - Therapie
JID - 0420544
SB  - IM
MH  - Biomedical Research/ethics/*legislation & jurisprudence
MH  - Clinical Trials as Topic/ethics/*legislation & jurisprudence
MH  - France
MH  - Humans
MH  - Informed Consent/legislation & jurisprudence
MH  - Legislation, Medical/ethics/*trends
MH  - Public Health/ethics/*legislation & jurisprudence
MH  - Risk
MH  - Therapeutic Human Experimentation
EDAT- 2012/08/02 06:00
MHDA- 2013/01/04 06:00
CRDT- 2012/08/02 06:00
PHST- 2012/03/20 00:00 [received]
PHST- 2012/03/23 00:00 [accepted]
PHST- 2012/08/02 06:00 [entrez]
PHST- 2012/08/02 06:00 [pubmed]
PHST- 2013/01/04 06:00 [medline]
AID - 10.2515/therapie/2012022 [doi]
AID - th122066 [pii]
PST - ppublish
SO  - Therapie. 2012 Mar-Apr;67(2):77-87. doi: 10.2515/therapie/2012022. Epub 2012 Aug 
      2.


PMID- 22849982
OWN - NLM
STAT- MEDLINE
DCOM- 20130204
LR  - 20220408
IS  - 2245-1919 (Electronic)
IS  - 2245-1919 (Linking)
VI  - 59
IP  - 8
DP  - 2012 Aug
TI  - Individual and environmental risk factors for high blood lead concentrations in
      Danish indoor shooters.
PG  - A4488
AB  - INTRODUCTION: International studies have shown blood lead at levels causing
      health concern in recreational indoor shooters. We hypothesized that Danish
      recreational indoor shooters would also have a high level of blood lead, and that
      this could be explained by shooting characteristics and the physical environment 
      at the shooting range. MATERIAL AND METHODS: This was an environmental case study
      of 58 male and female shooters from two indoor shooting ranges with assumed
      different ventilation and cleaning conditions. Information was obtained on
      general conditions including age, gender, tobacco and alcohol use, and shooting
      conditions: weapon type, number of shots fired, frequency of stays at the
      shooting range and hygiene habits. A venous blood sample was drawn to determine
      blood lead concentrations; 14 non-shooters were included as controls. RESULTS:
      Almost 60% of the shooters, hereof five out of 14 women, had a blood lead
      concentration above 0.48 micromol/l, a level causing long-term health concern.
      All controls had blood lead values below 0.17 micromol/l. Independent significant
      associations with blood lead concentrations above 0.48 micromol/l were found for 
      shooting at a poorly ventilated range, use of heavy calibre weapons, number of
      shots and frequency of stays at the shooting range. CONCLUSION: A large
      proportion of Danish recreational indoor shooters had potentially harmful blood
      lead concentrations. Ventilation, amounts of shooting, use of heavy calibre
      weapons and stays at the shooting ranges were independently associated with
      increased blood lead. FUNDING: The technical check at the two ranges was
      performed by the Danish Technological Institute and costs were defrayed by the
      Danish Rifle Association. To pay for the analyses of blood lead, the study was
      supported by the The Else & Mogens Wedell-Wedellsborg Foundation. TRIAL
      REGISTRATION: The Danish Regional Capital Scientific Ethics Committee approved
      the study, protocol number H-4-2010-130.
FAU - Grandahl, Kasper
AU  - Grandahl K
AD  - Arbejds- & Miljomedicinsk Afdeling, Bispebjerg Hospital, 2400 Copenhagen NV,
      Denmark. kgra0025@bbh.regionh.dk
FAU - Suadicani, Poul
AU  - Suadicani P
FAU - Jacobsen, Peter
AU  - Jacobsen P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Dan Med J
JT  - Danish medical journal
JID - 101576205
RN  - 0 (Air Pollutants)
RN  - 2P299V784P (Lead)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Air Pollutants/adverse effects/*blood
MH  - Air Pollution, Indoor/*adverse effects
MH  - Denmark
MH  - Environmental Exposure/*adverse effects
MH  - Female
MH  - *Firearms
MH  - Humans
MH  - Lead/*blood
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Recreation
MH  - Risk Factors
MH  - Statistics, Nonparametric
MH  - Time Factors
MH  - Ventilation
MH  - Young Adult
EDAT- 2012/08/02 06:00
MHDA- 2013/02/05 06:00
CRDT- 2012/08/02 06:00
PHST- 2012/08/02 06:00 [entrez]
PHST- 2012/08/02 06:00 [pubmed]
PHST- 2013/02/05 06:00 [medline]
AID - A4488 [pii]
PST - ppublish
SO  - Dan Med J. 2012 Aug;59(8):A4488.


PMID- 22849423
OWN - NLM
STAT- MEDLINE
DCOM- 20150728
LR  - 20181202
IS  - 1744-7682 (Electronic)
IS  - 1471-2598 (Linking)
VI  - 12
IP  - 11
DP  - 2012 Nov
TI  - Update on gene and stem cell therapy approaches for spinal muscular atrophy.
PG  - 1463-71
LID - 10.1517/14712598.2012.711306 [doi]
AB  - INTRODUCTION: Spinal muscular atrophy (SMA) is the leading genetic cause of
      pediatric death to which at present there is no effective therapeutic. The
      genetic defect is well characterized as a mutation in exon 7 of the survival of
      motor neuron (SMN) gene. The current gene therapy approach focuses on two main
      methodologies, the replacement of SMN1 or augmentation of SMN2 readthrough. The
      most promising of the current work focuses on the delivery of SMN via AAV9
      vectors via intravenous delivery. AREAS COVERED: In the review the authors
      examine the current research in the field of stem cell and gene therapy
      approaches for SMA. Also focusing on delivery methods, timing of administration
      and general caveats that must be considered with translational work for SMA.
      EXPERT OPINION: Gene therapy currently offers the most promising avenue of
      research for a successful therapeutic for SMA. There are many important practical
      and ethical considerations which must be carefully considered when dealing with
      clinical trial in infants such as the invasiveness of the surgery, the correct
      patient cohort and the potential risks.
FAU - Donnelly, Eleanor M
AU  - Donnelly EM
AD  - Emory University, Department of Neurosurgery, Atlanta, GA, USA.
FAU - Boulis, Nicholas M
AU  - Boulis NM
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120731
PL  - England
TA  - Expert Opin Biol Ther
JT  - Expert opinion on biological therapy
JID - 101125414
RN  - 0 (Survival of Motor Neuron 1 Protein)
RN  - 0 (Survival of Motor Neuron 2 Protein)
SB  - IM
MH  - Animals
MH  - Clinical Trials as Topic/methods
MH  - Genetic Therapy/methods/*trends
MH  - Genetic Vectors/administration & dosage/genetics
MH  - Humans
MH  - Muscular Atrophy, Spinal/diagnosis/*genetics/*therapy
MH  - Mutation/genetics
MH  - Stem Cell Transplantation/methods/*trends
MH  - Survival of Motor Neuron 1 Protein/genetics
MH  - Survival of Motor Neuron 2 Protein/genetics
EDAT- 2012/08/02 06:00
MHDA- 2015/07/29 06:00
CRDT- 2012/08/02 06:00
PHST- 2012/08/02 06:00 [entrez]
PHST- 2012/08/02 06:00 [pubmed]
PHST- 2015/07/29 06:00 [medline]
AID - 10.1517/14712598.2012.711306 [doi]
PST - ppublish
SO  - Expert Opin Biol Ther. 2012 Nov;12(11):1463-71. doi:
      10.1517/14712598.2012.711306. Epub 2012 Jul 31.


PMID- 22849249
OWN - NLM
STAT- MEDLINE
DCOM- 20120821
LR  - 20191112
IS  - 0823-2105 (Print)
IS  - 0823-2105 (Linking)
VI  - 29
IP  - 1
DP  - 2012
TI  - [Ethical aspirations and the reality of medical practice at the end of the Ancien
      Regime].
PG  - 29-48
AB  - At the end of the 18th century, economic survival was difficult for physicians.
      The medical market was crowded and to build (and seduce) a clientele, they had to
      pay particular attention to their appearance. Being well dressed and travelling
      by horse or in a carriage was necessary to demonstrate that they had a good
      reputation and were a "good" doctor. However, this still did not guarantee
      financial security for the doctor and his family. In an era when medical fees
      were only just beginning to be discussed, it was difficult to know how to bill
      patients and how to get paid. At the same time, the first texts on medical ethics
      appeared, insisting on modesty, authenticity, delicacy, and sincerity. In this
      article, by exploring personal archives and printed moral prescriptions, I will
      suggest that there were tensions between the everyday difficulties of medical
      practice and the recommendations on medical ethics, tensions that had
      consequences for the patient-doctor relationship.
FAU - Louis-Courvoisier, Micheline
AU  - Louis-Courvoisier M
AD  - Programme de Sciences humaines en medecine, Institut d'ethique biomedicale,
      Faculte de medecine, Geneve.
LA  - fre
PT  - English Abstract
PT  - Historical Article
PT  - Journal Article
TT  - Aspirations ethiques et realite de la pratique medicale a la fin de l'Ancien
      Regime.
PL  - Canada
TA  - Can Bull Med Hist
JT  - Canadian bulletin of medical history = Bulletin canadien d'histoire de la
      medecine
JID - 101130981
MH  - Ethics, Medical/*history
MH  - Europe
MH  - Fees, Medical/ethics/history
MH  - History, 18th Century
MH  - Humans
MH  - Physicians/economics/ethics/history
MH  - Practice Patterns, Physicians'/economics/ethics/*history
EDAT- 2012/08/02 06:00
MHDA- 2012/08/22 06:00
CRDT- 2012/08/02 06:00
PHST- 2012/08/02 06:00 [entrez]
PHST- 2012/08/02 06:00 [pubmed]
PHST- 2012/08/22 06:00 [medline]
AID - 10.3138/cbmh.29.1.29 [doi]
PST - ppublish
SO  - Can Bull Med Hist. 2012;29(1):29-48. doi: 10.3138/cbmh.29.1.29.


PMID- 22848954
OWN - NLM
STAT- MEDLINE
DCOM- 20120809
LR  - 20120801
IS  - 0029-6570 (Print)
IS  - 0029-6570 (Linking)
VI  - 26
IP  - 41
DP  - 2012 Jun 13-19
TI  - Educational responses to unethical healthcare practice.
PG  - 35-41
AB  - The aim of this article is to explore explanations for unethical healthcare
      practice and identify educational responses. The meaning of unethical practice is
      outlined and causes of it are suggested, primarily relating to individual
      perpetrators and organisational culture or climate. Empirical and theoretical
      literature is reviewed and research findings are discussed. Individual resilience
      and the ethical climate of healthcare organisations are considered as responses
      to unethical practice. Role modelling is explored, acknowledging the role of
      effective leadership.
FAU - Grob, Catherine
AU  - Grob C
AD  - School of Health and Social Care, Faculty of Health and Medical Sciences,
      University of Surrey, Guildford. c.grob@surrey.ac.uk
FAU - Leng, Jane
AU  - Leng J
FAU - Gallagher, Ann
AU  - Gallagher A
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Stand
JT  - Nursing standard (Royal College of Nursing (Great Britain) : 1987)
JID - 9012906
MH  - Curriculum
MH  - Education, Nursing/organization & administration
MH  - Empathy
MH  - *Ethics, Professional
MH  - Humans
MH  - Leadership
MH  - Organizational Culture
EDAT- 2012/08/02 06:00
MHDA- 2012/08/10 06:00
CRDT- 2012/08/02 06:00
PHST- 2012/08/02 06:00 [entrez]
PHST- 2012/08/02 06:00 [pubmed]
PHST- 2012/08/10 06:00 [medline]
AID - 10.7748/ns2012.06.26.41.35.c9159 [doi]
PST - ppublish
SO  - Nurs Stand. 2012 Jun 13-19;26(41):35-41. doi: 10.7748/ns2012.06.26.41.35.c9159.


PMID- 22847385
OWN - NLM
STAT- MEDLINE
DCOM- 20130329
LR  - 20220223
IS  - 1759-4766 (Electronic)
IS  - 1759-4758 (Linking)
VI  - 8
IP  - 9
DP  - 2012 Sep
TI  - Whole-genome and whole-exome sequencing in neurological diseases.
PG  - 508-17
LID - 10.1038/nrneurol.2012.148 [doi]
AB  - Genetic risk factors that underlie many rare and common neurological disorders
      remain poorly understood because of the multifactorial and heterogeneous nature
      of these complex traits. With the decreasing cost of massively parallel
      sequencing technologies, whole-genome and whole-exome sequencing will soon allow 
      the characterization of the full spectrum of sequence and structural variants
      present in each individual. Methods are being developed to parse the huge amount 
      of genomic data and to sift out which variants are associated with diseases.
      Numerous challenges are inherent in the identification of rare and common
      variants that have a role in complex neurological diseases, and tools are being
      developed to overcome these challenges. Given that genomic data will soon be the 
      main driver towards the goal of personalized medicine, future developments in the
      production and interpretation of data, as well as in ethics and counselling, will
      be needed for whole-genome and whole-exome sequencing to be used as informative
      tools in a clinical setting.
FAU - Foo, Jia-Nee
AU  - Foo JN
AD  - Human Genetics, Genome Institute of Singapore, A*STAR, 60 Biopolis Street, Genome
      #02-01, Singapore 138672.
FAU - Liu, Jian-Jun
AU  - Liu JJ
FAU - Tan, Eng-King
AU  - Tan EK
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120731
PL  - England
TA  - Nat Rev Neurol
JT  - Nature reviews. Neurology
JID - 101500072
SB  - IM
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genome, Human/genetics
MH  - *Genome-Wide Association Study
MH  - Genomics/*methods/trends
MH  - Humans
MH  - Neurodegenerative Diseases/*genetics
EDAT- 2012/08/01 06:00
MHDA- 2013/03/30 06:00
CRDT- 2012/08/01 06:00
PHST- 2012/08/01 06:00 [entrez]
PHST- 2012/08/01 06:00 [pubmed]
PHST- 2013/03/30 06:00 [medline]
AID - nrneurol.2012.148 [pii]
AID - 10.1038/nrneurol.2012.148 [doi]
PST - ppublish
SO  - Nat Rev Neurol. 2012 Sep;8(9):508-17. doi: 10.1038/nrneurol.2012.148. Epub 2012
      Jul 31.


PMID- 22847255
OWN - NLM
STAT- MEDLINE
DCOM- 20121213
LR  - 20181201
IS  - 1868-8551 (Electronic)
IS  - 1868-596X (Linking)
VI  - 29
IP  - 3
DP  - 2012
TI  - Screening of budesonide nanoformulations for treatment of inflammatory bowel
      disease in an inflamed 3D cell-culture model.
PG  - 275-85
LID - 10.14573/altex.2012.3.275 [doi]
AB  - Drug formulation screenings for treatment of inflammatory bowel disease (IBD) are
      mostly conducted in chemically induced rodent models that represent acute
      injury-caused inflammation instead of a chronic condition. To accurately screen
      drug formulations for chronic IBD, a relevant model that mimics the chronic
      condition in vitro is urgently needed. In an effort to reduce and potentially
      replace this scientifically and ethically questionable animal testing for IBD
      drugs, our laboratory has developed an in vitro model for the inflamed intestinal
      mucosa observed in chronic IBD, which allows high-throughput screening of
      anti-inflammatory drugs and their formulations. The in vitro model consists of
      intestinal epithelial cells, human blood-derived macrophages, and dendritic cells
      that are stimulated by the inflammatory cytokine interleukin-1beta. In this
      study, the model was utilized for evaluation of the efficacy and deposition of
      budesonide, an anti-inflammatory drug, in three different pharmaceutical
      formulations: (1) a free drug solution, (2) encapsulated into PLGA nanoparticles,
      and (3) encapsulated into liposomes. The in vitro model of the inflamed
      intestinal mucosa demonstrated its ability to differentiate therapeutic efficacy 
      among the formulations while maintaining the convenience of conventional in vitro
      studies and adequately representing the complex pathophysiological changes
      observed in vivo.
FAU - Leonard, Fransisca
AU  - Leonard F
AD  - Department of Biopharmaceutics and Pharmaceutical Technology, Saarland
      University, Saarbruecken, Germany.
FAU - Ali, Hussain
AU  - Ali H
FAU - Collnot, Eva-Maria
AU  - Collnot EM
FAU - Crielaard, Bart J
AU  - Crielaard BJ
FAU - Lammers, Twan
AU  - Lammers T
FAU - Storm, Gert
AU  - Storm G
FAU - Lehr, Claus-Michael
AU  - Lehr CM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - ALTEX
JT  - ALTEX
JID - 100953980
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Interleukin-8)
RN  - 0 (Liposomes)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 51333-22-3 (Budesonide)
SB  - IM
MH  - Animal Testing Alternatives/*methods
MH  - Anti-Inflammatory Agents/chemistry/*pharmacology
MH  - Budesonide/chemistry/*pharmacology
MH  - Caco-2 Cells
MH  - Cells, Cultured
MH  - Coculture Techniques
MH  - Dendritic Cells
MH  - Humans
MH  - Inflammatory Bowel Diseases/*drug therapy
MH  - Interleukin-1beta/toxicity
MH  - Interleukin-8/genetics/metabolism
MH  - Lactic Acid/chemistry
MH  - Liposomes
MH  - Macrophages
MH  - Microscopy, Confocal
MH  - Nanoparticles/*chemistry
MH  - Polyglycolic Acid/chemistry
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
EDAT- 2012/08/01 06:00
MHDA- 2012/12/14 06:00
CRDT- 2012/08/01 06:00
PHST- 2012/08/01 06:00 [entrez]
PHST- 2012/08/01 06:00 [pubmed]
PHST- 2012/12/14 06:00 [medline]
AID - 10.14573/altex.2012.3.275 [doi]
PST - ppublish
SO  - ALTEX. 2012;29(3):275-85. doi: 10.14573/altex.2012.3.275.


PMID- 22847147
OWN - NLM
STAT- MEDLINE
DCOM- 20120905
LR  - 20161017
IS  - 1538-3598 (Electronic)
IS  - 0098-7484 (Linking)
VI  - 308
IP  - 9
DP  - 2012 Sep 5
TI  - Ethical challenges of preexposure prophylaxis for HIV.
PG  - 867-8
LID - 10.1001/2012.jama.10158 [doi]
FAU - Jay, Jonathan S
AU  - Jay JS
AD  - O'Neill Institute for National and Global Health Law, Georgetown University Law
      Center, Washington, DC 20001, USA.
FAU - Gostin, Lawrence O
AU  - Gostin LO
LA  - eng
PT  - Journal Article
PL  - United States
TA  - JAMA
JT  - JAMA
JID - 7501160
RN  - 0 (Anti-Retroviral Agents)
RN  - 0 (Drug Combinations)
RN  - 0 (Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination)
RN  - 0 (Organophosphorus Compounds)
RN  - 0W860991D6 (Deoxycytidine)
SB  - IM
MH  - Anti-Retroviral Agents/*administration & dosage/adverse effects/economics
MH  - Cost-Benefit Analysis
MH  - Deoxycytidine/administration & dosage/adverse effects/*analogs &
      derivatives/economics
MH  - Drug Combinations
MH  - Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination
MH  - *Ethics, Medical
MH  - Female
MH  - HIV Infections/*prevention & control/transmission
MH  - HIV Seronegativity
MH  - Humans
MH  - Male
MH  - Medically Underserved Area
MH  - Organophosphorus Compounds/*administration & dosage/adverse effects/economics
MH  - Risk
MH  - Sexual Behavior
MH  - *Social Justice
MH  - *Unsafe Sex
EDAT- 2012/08/01 06:00
MHDA- 2012/09/06 06:00
CRDT- 2012/08/01 06:00
PHST- 2012/08/01 06:00 [entrez]
PHST- 2012/08/01 06:00 [pubmed]
PHST- 2012/09/06 06:00 [medline]
AID - 1262682 [pii]
AID - 10.1001/2012.jama.10158 [doi]
PST - ppublish
SO  - JAMA. 2012 Sep 5;308(9):867-8. doi: 10.1001/2012.jama.10158.


PMID- 22846794
OWN - NLM
STAT- MEDLINE
DCOM- 20130206
LR  - 20181201
IS  - 1878-5883 (Electronic)
IS  - 0022-510X (Linking)
VI  - 321
IP  - 1-2
DP  - 2012 Oct 15
TI  - Differences between younger and older individuals in their use of care and
      rehabilitation but not in self-perceived global recovery 1year after stroke.
PG  - 29-34
LID - 10.1016/j.jns.2012.07.024 [doi]
AB  - BACKGROUND: Although priorities in Swedish stroke care should be based on the
      ethical principles of equal care and greatest support to those in greatest need, 
      being of working age (younger) or retired (older) might influence expectations on
      recovery and the provision of care and rehabilitation. METHOD: Information
      regarding the use of care and rehabilitation during the 1st year after stroke was
      retrieved from the Stockholm County Council database and the medical data was
      taken from the medical records. The Barthel Index was used for self-ratings of
      dependence pre-stroke, and the Stroke Impact Scale was used to assess
      self-perceived disability and a global rating of recovery at 12 months. One
      hundred and ninety-two individuals were included. RESULTS: Results showed that
      the younger group received more care and rehabilitation than the older group. In 
      the older group, comorbid conditions and pre-stroke dependence, estimated in
      accordance with the Barthel Index, were more common. The older group reported
      larger impact on self-perceived disability regarding strength, mobility,
      self-care and domestic life, while self-perceived global recovery did not differ 
      between the groups. CONCLUSION: Younger individuals received more care and
      rehabilitation, which indicates structural inequality in the provision of health 
      care resources. However, as no difference in self-perceived global recovery was
      found between the groups; the disparity in the provision of health care may also 
      be a consequence of greatest support being given to those in greatest need. By
      demonstrating the necessity of involving self-rated assessments of stroke impact 
      at different points in time and in different age groups, the results of this
      study add to previous knowledge of age-related differences in the provision of
      health care and stroke outcome. Furthermore, this suggests a way to approach
      evaluation of equality in the provision of health care.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Palmcrantz, Susanne
AU  - Palmcrantz S
AD  - Division of Physiotherapy, Department of Neurobiology, Care Sciences and Society,
      Karolinska Institutet, Huddinge, Sweden. susanne.palmcrantz@ki.se
FAU - Holmqvist, Lotta Widen
AU  - Holmqvist LW
FAU - Sommerfeld, Disa K
AU  - Sommerfeld DK
FAU - Tistad, Malin
AU  - Tistad M
FAU - Ytterberg, Charlotte
AU  - Ytterberg C
FAU - von Koch, Lena
AU  - von Koch L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120728
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
SB  - IM
EIN - J Neurol Sci. 2013 May 15;328(1-2):106. Susanne, Palmcrantz [corrected to
      Palmcrantz, Susanne]; Lotta, Widen Holmqvist [corrected to Holmqvist, Lotta
      Widen]; K, Sommerfeld Disa [corrected to Sommerfeld, Disa K]; Malin, Tistad
      [corrected to Tistad, Malin]; Charlotte, Ytterberg [corrected to Ytt
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Aging
MH  - Delivery of Health Care/*statistics & numerical data
MH  - Disabled Persons/psychology/rehabilitation
MH  - Female
MH  - *Health Services Needs and Demand
MH  - Humans
MH  - Linear Models
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Pain Measurement
MH  - Recovery of Function/*physiology
MH  - Retrospective Studies
MH  - *Self Concept
MH  - Statistics, Nonparametric
MH  - Stroke/psychology
MH  - *Stroke Rehabilitation
MH  - Sweden
MH  - Young Adult
EDAT- 2012/08/01 06:00
MHDA- 2013/02/07 06:00
CRDT- 2012/08/01 06:00
PHST- 2012/03/26 00:00 [received]
PHST- 2012/06/29 00:00 [revised]
PHST- 2012/07/11 00:00 [accepted]
PHST- 2012/08/01 06:00 [entrez]
PHST- 2012/08/01 06:00 [pubmed]
PHST- 2013/02/07 06:00 [medline]
AID - S0022-510X(12)00358-9 [pii]
AID - 10.1016/j.jns.2012.07.024 [doi]
PST - ppublish
SO  - J Neurol Sci. 2012 Oct 15;321(1-2):29-34. doi: 10.1016/j.jns.2012.07.024. Epub
      2012 Jul 28.


PMID- 22846730
OWN - NLM
STAT- MEDLINE
DCOM- 20130130
LR  - 20130304
IS  - 1540-336X (Electronic)
IS  - 1528-9117 (Linking)
VI  - 18
IP  - 4
DP  - 2012 Jul-Aug
TI  - Adverse events in cancer genetic testing: medical, ethical, legal, and financial 
      implications.
PG  - 303-9
LID - 10.1097/PPO.0b013e3182609490 [doi]
AB  - Cancer genetic counseling and testing are now integral services in progressive
      cancer care. There has been much debate over whether these services should be
      delivered by providers with specialized training in genetics or by all
      clinicians. Adverse outcomes resulting from cancer genetic counseling and testing
      performed by clinicians without specialization in genetics have been reported,
      but formal documentation is sparse. In this review, we present a series of
      national cases illustrating major patterns of errors in cancer genetic counseling
      and testing and the resulting impact on medical liability, health care costs, and
      the patients and their families.
FAU - Brierley, Karina L
AU  - Brierley KL
AD  - Cancer Genetic Counseling, Yale Cancer Center, Yale University School of
      Medicine, New Haven, CT 06510, USA. karina.brierley@yale.edu
FAU - Blouch, Erica
AU  - Blouch E
FAU - Cogswell, Whitney
AU  - Cogswell W
FAU - Homer, Jeanne P
AU  - Homer JP
FAU - Pencarinha, Debbie
AU  - Pencarinha D
FAU - Stanislaw, Christine L
AU  - Stanislaw CL
FAU - Matloff, Ellen T
AU  - Matloff ET
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Cancer J
JT  - Cancer journal (Sudbury, Mass.)
JID - 100931981
SB  - IM
MH  - Diagnostic Errors
MH  - Female
MH  - *Genetic Counseling/economics/ethics/legislation & jurisprudence/standards
MH  - Genetic Predisposition to Disease
MH  - *Genetic Testing/economics/ethics/legislation & jurisprudence/standards
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Liability, Legal
MH  - Medical Errors
MH  - Neoplasms/*genetics
MH  - Risk Assessment
MH  - Unnecessary Procedures
EDAT- 2012/08/01 06:00
MHDA- 2013/01/31 06:00
CRDT- 2012/08/01 06:00
PHST- 2012/08/01 06:00 [entrez]
PHST- 2012/08/01 06:00 [pubmed]
PHST- 2013/01/31 06:00 [medline]
AID - 10.1097/PPO.0b013e3182609490 [doi]
AID - 00130404-201207000-00004 [pii]
PST - ppublish
SO  - Cancer J. 2012 Jul-Aug;18(4):303-9. doi: 10.1097/PPO.0b013e3182609490.


PMID- 22846729
OWN - NLM
STAT- MEDLINE
DCOM- 20130130
LR  - 20220310
IS  - 1540-336X (Electronic)
IS  - 1528-9117 (Linking)
VI  - 18
IP  - 4
DP  - 2012 Jul-Aug
TI  - Direct-to-consumer personal genome testing and cancer risk prediction.
PG  - 293-302
LID - 10.1097/PPO.0b013e3182610e38 [doi]
AB  - The last several years has witnessed an explosion in genomics, with the advent of
      genome-wide association studies revealing hundreds of DNA variants significantly 
      associated with most common diseases, including cancer. On the heels of these
      scientific advances came the direct-to-consumer (DTC) genetic testing industry.
      Genome-wide scans for disease have been marketed and sold directly to the public,
      without the involvement of a health care provider. Unlike genetic testing for
      mutations in known hereditary cancer susceptibility genes such as BRCA1/2, these 
      genomic profiles examine DNA variants, which typically have a minimal risk
      impact, and account for only a fraction of the heritable component of cancer.
      Furthermore, risk information provided to consumers does not account for family
      history or other known risk factors. The clinical validity and utility of
      personal genome scans for disease risk prediction remain for the most part
      unestablished, although some argue lack of evidence of harm and the possibility
      that positive impacts on health behaviors or genetic awareness may result from
      consumer use. The DTC genetic testing industry has sparked significant
      controversy not only among the scientific community, but also among professional 
      societies and government agencies.In this review, we present some of the history 
      and methodological considerations of DTC genomic profiling, with a focus on
      cancer risk prediction. The literature regarding consumer awareness and
      utilization is explored, including understanding, expectations, and behavioral
      and psychological responses to DTC genomic risk prediction. Primary care provider
      and genetic professional knowledge and perceptions of DTC genomic profiling are
      also addressed. Ethical and scientific controversy surrounding the DTC genetic
      testing industry is presented, along with policy recommendations, regulatory
      actions, and the changing landscape of the DTC genetic testing market in
      response. Although our understanding of the human genome holds much promise in
      the realm of cancer prevention and treatment, DTC genomic profiling for cancer
      risk prediction is unlikely in its current form to have any significant impact on
      the health of the public. Time will tell if the next venture in genomic medicine,
      whole genome sequencing, will be accompanied by the translational research and
      emphasis on public/provider education required to ensure its successful
      application toward reducing the burden of cancer at a population level.
FAU - Bellcross, Cecelia A
AU  - Bellcross CA
AD  - Department of Human Genetics, Emory University School of Medicine, Atlanta, GA,
      USA. cbellcr@emory.edu
FAU - Page, Patricia Z
AU  - Page PZ
FAU - Meaney-Delman, Dana
AU  - Meaney-Delman D
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Cancer J
JT  - Cancer journal (Sudbury, Mass.)
JID - 100931981
SB  - IM
MH  - Community Participation
MH  - Gene Expression Profiling
MH  - *Genetic Counseling
MH  - *Genetic Testing
MH  - Genome, Human
MH  - Genomics
MH  - Humans
MH  - Neoplasms/*genetics
MH  - Precision Medicine
MH  - Risk Factors
MH  - Sequence Analysis, DNA
EDAT- 2012/08/01 06:00
MHDA- 2013/01/31 06:00
CRDT- 2012/08/01 06:00
PHST- 2012/08/01 06:00 [entrez]
PHST- 2012/08/01 06:00 [pubmed]
PHST- 2013/01/31 06:00 [medline]
AID - 10.1097/PPO.0b013e3182610e38 [doi]
AID - 00130404-201207000-00003 [pii]
PST - ppublish
SO  - Cancer J. 2012 Jul-Aug;18(4):293-302. doi: 10.1097/PPO.0b013e3182610e38.


PMID- 22846592
OWN - NLM
STAT- MEDLINE
DCOM- 20130207
LR  - 20181201
IS  - 1528-8447 (Electronic)
IS  - 1526-5900 (Linking)
VI  - 13
IP  - 9
DP  - 2012 Sep
TI  - Contemporary use of the cold pressor task in pediatric pain research: a
      systematic review of methods.
PG  - 817-26
LID - 10.1016/j.jpain.2012.06.005 [doi]
AB  - UNLABELLED: The cold pressor task (CPT) is an ethical experimental pain task
      widely used by pediatric pain researchers to examine a variety of important
      theoretical and clinical questions. The purpose of this systematic review was to 
      describe contemporary use of the CPT in pediatric pain research to identify
      possible methodological and procedural inconsistencies and inform future
      research. All papers using the CPT to examine pain-related outcomes in children
      </=18 years old published after 2005 were identified, 2005 being when published
      pediatric CPT studies were last reviewed and guidelines for pediatric use of the 
      CPT were published. Information related to samples, CPT methodology, and pain
      outcomes was recorded. Thirty-six published papers, involving 2,242 children
      (aged 3-18 years) from both healthy and clinical samples, met review inclusion
      criteria. Several aspects of CPT methodology with significant potential to impact
      pain outcomes were found to be inconsistently implemented and reported, including
      water temperature, use of informed versus uninformed ceilings, and the presence
      of observers during the CPT. Self-report child pain intensity and pain tolerance 
      were common outcomes. A number of refinements for use of the CPT in pediatric
      pain research are suggested. PERSPECTIVE: The cold pressor task is a commonly
      used experimental method in pediatric pain research. This systematic review
      reveals important methodological inconsistencies in its use and suggestions for
      improvements to previously published guidelines.
CI  - Copyright (c) 2012 American Pain Society. Published by Elsevier Inc. All rights
      reserved.
FAU - Birnie, Kathryn A
AU  - Birnie KA
AD  - Department of Psychology, Dalhousie University, Halifax, Nova Scotia, Canada.
      kbirnie@dal.ca
FAU - Petter, Mark
AU  - Petter M
FAU - Boerner, Katelynn E
AU  - Boerner KE
FAU - Noel, Melanie
AU  - Noel M
FAU - Chambers, Christine T
AU  - Chambers CT
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20120729
PL  - United States
TA  - J Pain
JT  - The journal of pain
JID - 100898657
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Cold Temperature/*adverse effects
MH  - Databases, Factual/statistics & numerical data
MH  - Female
MH  - Humans
MH  - Male
MH  - Pain/*physiopathology
MH  - Pain Measurement/methods
MH  - *Pediatrics
MH  - *Research Design
EDAT- 2012/08/01 06:00
MHDA- 2013/02/08 06:00
CRDT- 2012/08/01 06:00
PHST- 2012/02/23 00:00 [received]
PHST- 2012/05/17 00:00 [revised]
PHST- 2012/06/19 00:00 [accepted]
PHST- 2012/08/01 06:00 [entrez]
PHST- 2012/08/01 06:00 [pubmed]
PHST- 2013/02/08 06:00 [medline]
AID - S1526-5900(12)00702-X [pii]
AID - 10.1016/j.jpain.2012.06.005 [doi]
PST - ppublish
SO  - J Pain. 2012 Sep;13(9):817-26. doi: 10.1016/j.jpain.2012.06.005. Epub 2012 Jul
      29.


PMID- 22846539
OWN - NLM
STAT- MEDLINE
DCOM- 20121204
LR  - 20190710
IS  - 1662-2979 (Electronic)
IS  - 1421-7082 (Linking)
VI  - 22
DP  - 2012
TI  - High-risk sexual behaviors.
PG  - 357-379
LID - 10.1159/000331653 [doi]
AB  - Adolescence is a time of life characterized by danger because of the many changes
      that occur, the many ties that are severed: ties to childhood, ties to the
      child's body as it begins to take on an adult appearance, ties to a once-familiar
      body image and psyche as hormones complete the transformation to adulthood, ties 
      to an unconscious that is struggling to restructure itself anew. The creation of 
      the romantic couple is a danger inherent in any human society. This text was
      written from the professional practices of each author in a multidisciplinary
      approach combining the approaches of public health, risk reduction, and sexual,
      psychological and clinical care of adolescents. How to help anticipate the
      dangers is to use preventive insurance verifying that security is guaranteed
      before committing. Risk-taking is accepting all the challenges that boost the
      self with oneself and with others. The risk is therefore also the commitment in
      love. It is still the risk to speak, to feel, to express feelings, choices, and
      refusal of unwanted sex. The ability of adolescents to play and defeat the risk
      by learning the ethical value not only to protect themselves from contracting
      AIDS, but also to protect others is part of the pedagogy of risk. This pedagogy
      of risk, as we have seen, includes three areas: information, care and initiation 
      into love. Adolescents must be supported in their emergence by responsible people
      to protect them from the dangers ahead. The support is not only to prevent them
      from engaging in risky behavior, but to help them better manage their anxieties
      and support the fragility of their families in a network approach. Not knowing
      how to confront the risk stifles the chance of allowing the child to grow up to
      be independent and helps reassure parents who may resent being removed from the
      empowerment of their children.
CI  - Copyright (c) 2012 S. Karger AG, Basel.
FAU - Troussier, Thierry
AU  - Troussier T
FAU - Benghozi, Pierre
AU  - Benghozi P
FAU - Ganem, Marc
AU  - Ganem M
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120725
PL  - Switzerland
TA  - Endocr Dev
JT  - Endocrine development
JID - 101138956
SB  - IM
MH  - Adolescent
MH  - Adolescent Health Services/organization & administration
MH  - Adult
MH  - Child
MH  - Female
MH  - Humans
MH  - Male
MH  - Psychology, Adolescent/education
MH  - *Risk-Taking
MH  - Sex Education
MH  - *Sexual Behavior/physiology/psychology
MH  - *Unsafe Sex/prevention & control/statistics & numerical data
MH  - Young Adult
EDAT- 2012/08/01 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/08/01 06:00
PHST- 2012/08/01 06:00 [entrez]
PHST- 2012/08/01 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 000331653 [pii]
AID - 10.1159/000331653 [doi]
PST - ppublish
SO  - Endocr Dev. 2012;22:357-379. doi: 10.1159/000331653. Epub 2012 Jul 25.


PMID- 22846056
OWN - NLM
STAT- MEDLINE
DCOM- 20150409
LR  - 20140506
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 28
IP  - 5
DP  - 2014 Jun
TI  - A critical analysis and discussion of clinical research ethics in the Russian
      Federation and their implications for Western sponsored trials.
PG  - 263-8
LID - 10.1111/j.1467-8519.2012.02002.x [doi]
AB  - Globalization, political upheavals, and Western economic struggles have caused a 
      geographical reprioritization in the realm of drug development and human clinical
      research. Regulatory and cost hurdles as well as a saturation of research sites
      and subjects in Western countries have forced the pharmaceutical industry to
      place an unprecedented level of importance on emerging markets, injecting Western
      corporate initiatives into cultures historically and socially isolated from
      Western-centric value systems. One of the greatest recipients of this onslaught
      of Western business and research practices is the Russian Federation. Namely,
      market forces are dictating a focused research initiative in the traditional
      emerging markets, but this focus may be at the expense of individual and societal
      dignity.
CI  - (c) 2012 John Wiley & Sons Ltd.
FAU - Leintz, Christopher
AU  - Leintz C
LA  - eng
PT  - Journal Article
DEP - 20120729
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - *Bioethics
MH  - Biomedical Research/*ethics
MH  - Commerce/*ethics
MH  - *Culture
MH  - Drug Industry/*ethics
MH  - *Ethics, Business
MH  - Ethics, Research
MH  - Humans
MH  - *Internationality
MH  - Personhood
MH  - Russia
MH  - Social Values
OTO - NOTNLM
OT  - Russia
OT  - clinical research
OT  - ethics
EDAT- 2012/08/01 06:00
MHDA- 2015/04/10 06:00
CRDT- 2012/08/01 06:00
PHST- 2012/08/01 06:00 [entrez]
PHST- 2012/08/01 06:00 [pubmed]
PHST- 2015/04/10 06:00 [medline]
AID - 10.1111/j.1467-8519.2012.02002.x [doi]
PST - ppublish
SO  - Bioethics. 2014 Jun;28(5):263-8. doi: 10.1111/j.1467-8519.2012.02002.x. Epub 2012
      Jul 29.


PMID- 22845856
OWN - NLM
STAT- MEDLINE
DCOM- 20130528
LR  - 20130409
IS  - 1537-2995 (Electronic)
IS  - 0041-1132 (Linking)
VI  - 53
IP  - 4
DP  - 2013 Apr
TI  - Ethical issues in umbilical cord blood banking: a comparative analysis of
      documents from national and international institutions.
PG  - 902-10
LID - 10.1111/j.1537-2995.2012.03824.x [doi]
AB  - The issues of collection, storage, and use of cord blood (CB) stem cells have
      been addressed extensively in national and international guidelines, policies,
      and regulations. Many of these documents are not binding, but are nonetheless
      accorded considerable respect on account of the authority of the issuing
      organizations. Most discussion has to date focused on two topics: informed
      consent for collection, banking, and use and the debate between those who favor
      public storage for altruistic purposes and those who advocate private storage for
      autologous use. There is generally agreement or consensus in the guidelines that 
      public storage for allogeneic transplants is preferable and that private storage 
      should be discouraged. Given the consensus in national and international guidance
      on these two issues, it is time for other ethical issues to be examined in
      greater detail. These include additional uses of CB samples, for example, for
      research or for the production of blood-derived drugs, and the economic
      implications arising from the extensive international network for the exchange of
      CB for transplantation.
CI  - (c) 2012 American Association of Blood Banks.
FAU - Petrini, Carlo
AU  - Petrini C
AD  - Bioethics Unit, Office of the President, Istituto Superiore di Sanita-National
      Institute of Health, Rome, Italy. carlo.petrini@iss.it
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
DEP - 20120731
PL  - United States
TA  - Transfusion
JT  - Transfusion
JID - 0417360
SB  - IM
MH  - Blood Banks/*ethics
MH  - Blood Preservation/*ethics
MH  - Cord Blood Stem Cell Transplantation/ethics
MH  - *Fetal Blood/cytology
MH  - *Fetal Stem Cells
MH  - Humans
MH  - Informed Consent/ethics
MH  - International Cooperation
MH  - Practice Guidelines as Topic
EDAT- 2012/08/01 06:00
MHDA- 2013/05/29 06:00
CRDT- 2012/08/01 06:00
PHST- 2012/08/01 06:00 [entrez]
PHST- 2012/08/01 06:00 [pubmed]
PHST- 2013/05/29 06:00 [medline]
AID - 10.1111/j.1537-2995.2012.03824.x [doi]
PST - ppublish
SO  - Transfusion. 2013 Apr;53(4):902-10. doi: 10.1111/j.1537-2995.2012.03824.x. Epub
      2012 Jul 31.


PMID- 22845721
OWN - NLM
STAT- MEDLINE
DCOM- 20140714
LR  - 20140103
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 28
IP  - 2
DP  - 2014 Feb
TI  - Islamic views on artificial nutrition and hydration in terminally ill patients.
PG  - 96-9
LID - 10.1111/j.1467-8519.2012.01996.x [doi]
AB  - Withholding and withdrawing artificial nutrition and hydration from terminally
      ill patients poses many ethical challenges. The literature provides little
      information about the Islamic beliefs, attitudes, and laws related to these
      challenges. Artificial nutrition and hydration may be futile and reduce quality
      of life. They can also harm the terminally ill patient because of complications
      such as aspiration pneumonia, dyspnea, nausea, diarrhea, and hypervolemia. From
      the perspective of Islam, rules governing the care of terminally ill patients are
      derived from the principle that injury and harm should be prevented or avoided.
      The hastening of death by the withdrawal of food and drink is forbidden, but
      Islamic law permits the withdrawal of futile, death-delaying treatment, including
      life support. Nutritional support is considered basic care and not medical
      treatment, and there is an obligation to provide nutrition and hydration for the 
      dying person unless it shortens life, causes more harm than benefit, or is
      contrary to an advance directive that is consistent with Islamic law. The
      decision about withholding or withdrawing artificial nutrition and hydration from
      the terminally ill Muslim patient is made with informed consent, considering the 
      clinical context of minimizing harm to the patient, with input from the patient, 
      family members, health care providers, and religious scholars.
CI  - (c) 2012 John Wiley & Sons Ltd.
FAU - Alsolamy, Sami
AU  - Alsolamy S
AD  - King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical
      City.
LA  - eng
PT  - Journal Article
DEP - 20120729
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
RN  - 059QF0KO0R (Water)
SB  - IM
MH  - *Cultural Competency
MH  - Decision Making
MH  - Ethics, Medical
MH  - Humans
MH  - Informed Consent
MH  - *Islam
MH  - *Nutritional Support
MH  - *Palliative Care
MH  - Religion and Medicine
MH  - *Terminal Care
MH  - *Terminally Ill
MH  - *Water
OTO - NOTNLM
OT  - Islam
OT  - end of life
OT  - medical ethics
EDAT- 2012/08/01 06:00
MHDA- 2014/07/16 06:00
CRDT- 2012/08/01 06:00
PHST- 2012/08/01 06:00 [entrez]
PHST- 2012/08/01 06:00 [pubmed]
PHST- 2014/07/16 06:00 [medline]
AID - 10.1111/j.1467-8519.2012.01996.x [doi]
PST - ppublish
SO  - Bioethics. 2014 Feb;28(2):96-9. doi: 10.1111/j.1467-8519.2012.01996.x. Epub 2012 
      Jul 29.


PMID- 22844818
OWN - NLM
STAT- MEDLINE
DCOM- 20121106
LR  - 20120731
IS  - 0033-2658 (Print)
IS  - 0033-2658 (Linking)
VI  - 114
IP  - 6
DP  - 2012
TI  - [The history of the concept of gender identity disorder].
PG  - 673-80
AB  - The Metamorphoses Greek myth includes a story about a woman raised as a male
      falling in love with another woman, and being transformed into a man prior to a
      wedding ceremony and staying with her. It is therefore considered that people who
      desire to live as though they have the opposite gender have existed since ancient
      times. People who express a sense of discomfort with their anatomical sex and
      related roles have been reported in the medical literature since the middle of
      the 19th century. However, homosexual, fetishism, gender identity disorder, and
      associated conditions were mixed together and regarded as types of sexual
      perversion that were considered ethically objectionable until the 1950s. The
      first performance of sex-reassignment surgery in 1952 attracted considerable
      attention, and the sexologist Harry Benjamin reported a case of 'a woman kept in 
      the body of a man', which was called transsexualism. John William Money studied
      the sexual consciousness about disorders of sex development and advocated the
      concept of gender in 1957. Thereafter the disparity between anatomical sex and
      gender identity was referred to as the psychopathological condition of gender
      identity disorder, and this was used for its diagnostic name when it was
      introduced into DSM-III in 1980. However, gender identity disorder encompasses a 
      spectrum of conditions, and DSM-III -R categorized it into three types:
      transsexualism, nontranssexualism, and not otherwise specified. The first two
      types were subsequently combined and standardized into the official diagnostic
      name of 'gender identity disorder' in DSM-IV. In contrast, gender identity
      disorder was categorized into four groups (including transsexualism and dual-role
      transvestism) in ICD-10. A draft proposal of DSM-5 has been submitted, in which
      the diagnostic name of gender identity disorder has been changed to gender
      dysphoria. Also, it refers to 'assigned gender' rather than to 'sex', and
      includes disorders of sexual development. Moreover, the subclassifications
      regarding sexual orientation have been deleted. The proposed DSM-5 reflects an
      attempt to include only a medical designation of people who have suffered due to 
      the gender disparity, thereby respecting the concept of transgender in accepting 
      the diversity of the role of gender. This indicates that transgender issues are
      now at a turning point.
FAU - Koh, Jun
AU  - Koh J
AD  - Department of Neuropsychiatry, Osaka Medecal College.
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Seishin Shinkeigaku Zasshi
JT  - Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica
JID - 9801787
SB  - IM
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Female
MH  - *Gender Identity
MH  - Humans
MH  - International Classification of Diseases
MH  - Male
MH  - Sex Reassignment Surgery
MH  - Sexual Behavior/physiology
MH  - Sexual and Gender Disorders/classification/*diagnosis/therapy
MH  - *Terminology as Topic
MH  - Transsexualism/classification/*diagnosis/psychology/surgery
EDAT- 2012/08/01 06:00
MHDA- 2012/11/07 06:00
CRDT- 2012/08/01 06:00
PHST- 2012/08/01 06:00 [entrez]
PHST- 2012/08/01 06:00 [pubmed]
PHST- 2012/11/07 06:00 [medline]
PST - ppublish
SO  - Seishin Shinkeigaku Zasshi. 2012;114(6):673-80.


PMID- 22844817
OWN - NLM
STAT- MEDLINE
DCOM- 20121106
LR  - 20120731
IS  - 0033-2658 (Print)
IS  - 0033-2658 (Linking)
VI  - 114
IP  - 6
DP  - 2012
TI  - [Improvement of therapeutic environment--effort to establish the medical center
      for GID in a general hospital].
PG  - 666-72
AB  - Treatment for gender identity disorder (GID) should be done in cooperation with
      psychologist, gynecologist, urologist, plastic surgeon and extramural scholars as
      a team treatment. And if possible, it should be a comprehensive treatment with
      supports of a social worker, a coordinator and an expert nurse. The ethical
      committee for individual GID patient treatment has already dissolved according to
      the third edition of the guideline. We call the therapeutic team Okayama
      University Hospital Gender Center. It treats not only GID patients, but also
      gender associated diseases such as disorders of sex development (DSD).
      Unfortunately, there are not so many institutions which meet our conditions
      throughout the country. In the present circumstances we can't go along with their
      needs. So many GID patients go abroad and have Sex reassignment surgery (SRS). To
      solve this problem national insurance for SRS should be approved as soon as
      possible and many institutes should start GID treatment.
FAU - Namba, Yuzaburo
AU  - Namba Y
AD  - Department of Plastic and Reconstructive Surgery, Okayama University.
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Seishin Shinkeigaku Zasshi
JT  - Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica
JID - 9801787
SB  - IM
MH  - Female
MH  - *Gender Identity
MH  - *Guidelines as Topic
MH  - Hospitals
MH  - Hospitals, General
MH  - Humans
MH  - Japan
MH  - Male
MH  - *Reconstructive Surgical Procedures
MH  - Sex Reassignment Surgery/*methods
MH  - Sexual and Gender Disorders/*surgery
MH  - Transsexualism/*surgery
EDAT- 2012/08/01 06:00
MHDA- 2012/11/07 06:00
CRDT- 2012/08/01 06:00
PHST- 2012/08/01 06:00 [entrez]
PHST- 2012/08/01 06:00 [pubmed]
PHST- 2012/11/07 06:00 [medline]
PST - ppublish
SO  - Seishin Shinkeigaku Zasshi. 2012;114(6):666-72.


PMID- 22828243
OWN - NLM
STAT- MEDLINE
DCOM- 20121205
LR  - 20181201
IS  - 1120-9763 (Print)
IS  - 1120-9763 (Linking)
VI  - 36
IP  - 3-4 Suppl 1
DP  - 2012 May-Aug
TI  - [Health technology assessment report: HPV DNA based primary screening for
      cervical cancer precursors].
PG  - e1-72
AB  - UNLABELLED: OBJECTIVE OF THE PROJECT: The introduction of the HPV test as a
      primary screening test will cause important changes in the screening system based
      on cytology. The purposes of this report are: to define the best screening
      policies with HPV-based screening on the basis of the resulting efficacy and of
      undesired effects; comparing them to cytology-based screening; to identify their 
      best conditions of application; to evaluate economic cost, feasibility and impact
      on the organisation of services of such policy in the Italian situation.
      CONTENTS: This report contains a section on efficacy and undesired effects based 
      on a systematic review of literature conducted in strict coordination with the
      preparation of a supplement to the European Guidelines for quality assurance in
      cervical cancer screening. This chapter corresponds to a preliminary version of
      the chapter of the European Guidelines on primary screening with HPV. The
      sections on costs, impact on organisation, and social, ethical and legal impact
      reflect the Italian situation; they are based on a review of the available
      Italian data (including unpublished data, mainly from on-going pilot projects)
      and on a structured analysis of what will result if the proposed protocol is
      applied to the Italian situation. RESULTS: Efficacy and undesired effects. There 
      is clear scientific evidence that a screening based on validated tests for the
      DNA of oncogenic HPV as primary test and applying an appropriate protocol is more
      effective than screening based on cytology in preventing invasive cancers of the 
      uterine cervix. In addition, it entails a limited--if any--increase of the
      undesired effects both in terms of unneeded referral to diagnostic work-up and in
      terms of over-diagnosis and consequent overtreatment of spontaneously regressive 
      lesions. The crucial elements of such protocol are the followings: HPV-positive
      women are not to be directly referred to colposcopy, but the use of triage
      systems is essential. The currently recommendable method is based on performing
      cytology in HPV positive women. If the result of this test is abnormal, the woman
      is immediately referred to colposcopy; if cytology is normal, the woman is
      invited to repeat a new HPV test after one year. In case such a test is still
      positive, the woman is referred to colposcopy; in case of negative result, the
      woman will be re-invited for a new screening round at the regular interval. In
      organised population-based screening programmes the interval after a negative
      primary HPV test should be at least 5 years. There is evidence that the 5-year
      cumulative risk of high-grade CIN after a negative HPV test is lower than the
      3-year risk after a normal cytology. On the other hand, the probability of
      unneeded colposcopies and treatments would plausibly be relevant with 3-year
      intervals after a negative HPV test. HPV-based screening should not start before 
      30-35 years. There is evidence that below 30 years HPV-based screening leads to
      an increased overdiagnosis of CIN2 that would regress spontaneously, with
      consequent overtreatment. Some increase in overdiagnosis is plausible also
      between 30 and 34 years. Below such ages, cytological screening is the
      recommended test. Only tests for the DNA of oncogenic HPV, validated according to
      the European guidelines as for sensitivity and specificity for high-grade
      lesions, should be applied. There is no evidence that double testing with
      cytology and HPV is more protective than stand-alone HPV as primary test,
      although it entails a small and not relevant increase in sensitivity vs
      stand-alone HPV. On the contrary, there is evidence that double testing causes a 
      substantial increase in referral to colposcopy and a decrease in its PPV. For
      this reason, if HPV is used as primary screening test, it is recommended not to
      add cytology in parallel. Cost and economic evaluation. It is estimated that, if 
      the protocol described is applied, in the current Italian situation the overall
      costs of HPV-based screening are lower than those of conventional cytological
      screening applied at the current 3-year intervals, although the cost of each
      screening round is higher. Impact on organization. For reasons of quality and
      cost, both the interpretation of cytology and HPV testing require a
      centralisation. This need is particularly strong, in terms of costs, for HPV test
      execution. It is therefore recommended to perform the HPV test in a limited
      number of reference laboratories of large size. This also makes monitoring and
      evaluating the spontaneous activity easier. HPV-based screening entails problems 
      of organisation related to the need of triage, to complex protocols and to
      reconversion of the activities of cytological interpretation. Social, ethical and
      legal impact. The communication of the result of the HPV test to women,
      particularly if positive, is a further crucial aspect in order to reduce not only
      the emotional impact, but also the possible risks that women are inappropriately 
      managed or lost to follow-up. Great efforts must be put in the education of
      healthcare professionals, both directly involved in organised programmes or not, 
      particularly private gynaecologists and general practitioners. RECOMMENDATIONS:
      In conclusion, the crucial requirement to introduce HPV-based screening
      programmes is the capacity to guarantee the application of appropriate screening 
      protocols. If protocols do not respect the criteria described above they can
      cause relevant increase of undesired effects and costs compared to cytology-based
      screening. Therefore they should be avoided, except in studies able to provide
      clear evidence about human and economic costs. For this purpose, correct
      education and information both to healthcare professionals and to the population 
      is needed. In the Italian situation, where organised screening and a relevant
      spontaneous activity coexist, their interaction is crucial. Actions directed to
      integrate them and to guarantee as more uniformity of interventions as possible
      are needed, in particular through the integration of registries and thorough
      monitoring and a progressive homogenization of protocols. In order to grant the
      safety of transition, it is needed that the HPV-based organised screening
      activities are strictly monitored and that the National Centre for Screening
      Monitoring (ONS) ensures coordination. Knowledge about HPV based screening is
      still rapidly evolving. It is possible that currently on-going researches suggest
      changes to the optimal protocols in the next few years, particularly as for the
      management of HPV positive women. In addition, studies on the validation of new
      assays were recently published and others are expected. It is suggested to
      exploit the organised screening activity to produce scientific evidence, in order
      to clarify the still uncertain aspects of optimal protocols. Different protocols 
      in terms of screening intervals, age of application and management of HPV
      positive women should be studied in the frame of controlled implementation,
      through multicentre projects coordinated by ONS. Finally, it is suggested the
      creation of a National working group to promptly update the recommendations for
      screening and the list of assays to be considered as validated. On the bases of
      the results obtained in the first vaccinated cohorts reaching the screening age, 
      for the future, it will be crucial to deliver specific recommendations to the
      population vaccinated against HPV during adolescence.
FAU - Ronco, Guglielmo
AU  - Ronco G
AD  - Centro di Riferimento per l'Epidemiologia e la Prevenzione Oncologica in
      Piemonte, Via San Francesco da Paola 31, 10123 Torino.
FAU - Biggeri, Annibale
AU  - Biggeri A
FAU - Confortini, Massimo
AU  - Confortini M
FAU - Naldoni, Carlo
AU  - Naldoni C
FAU - Segnan, Nereo
AU  - Segnan N
FAU - Sideri, Mario
AU  - Sideri M
FAU - Zappa, Marco
AU  - Zappa M
FAU - Zorzi, Manuel
AU  - Zorzi M
FAU - Calvia, Maria
AU  - Calvia M
FAU - Accetta, Gabriele
AU  - Accetta G
FAU - Giordano, Livia
AU  - Giordano L
FAU - Cogo, Carla
AU  - Cogo C
FAU - Carozzi, Francesca
AU  - Carozzi F
FAU - Gillio Tos, Anna
AU  - Gillio Tos A
FAU - Arbyn, Marc
AU  - Arbyn M
FAU - Mejier, Chris J L M
AU  - Mejier CJ
FAU - Snijders, Peter J F
AU  - Snijders PJ
FAU - Cuzick, Jack
AU  - Cuzick J
FAU - Giorgi Rossi, Paolo
AU  - Giorgi Rossi P
LA  - ita
PT  - Journal Article
TT  - Health technology assessment report: ricerca del DNA di papillomavirus umano
      (HPV) come test primario per lo screening dei precursori del cancro del collo
      dell'utero.
PL  - Italy
TA  - Epidemiol Prev
JT  - Epidemiologia e prevenzione
JID - 8902507
SB  - IM
MH  - Adult
MH  - Alphapapillomavirus/genetics/isolation & purification
MH  - Cervical Intraepithelial Neoplasia/*diagnosis/epidemiology/virology
MH  - Colposcopy
MH  - Cost-Benefit Analysis
MH  - Female
MH  - Guidelines as Topic
MH  - Health Policy
MH  - Human Papillomavirus DNA Tests/economics/*statistics & numerical data
MH  - Humans
MH  - Italy/epidemiology
MH  - Mass Screening/economics/legislation & jurisprudence/organization &
      administration/*statistics & numerical data
MH  - Papillomavirus Infections/*diagnosis/epidemiology/virology
MH  - Precancerous Conditions/*diagnosis/epidemiology/virology
MH  - Predictive Value of Tests
MH  - Program Evaluation
MH  - Truth Disclosure
MH  - Uterine Cervical Neoplasms/diagnosis/epidemiology/*prevention & control/virology
MH  - Uterine Cervicitis/*diagnosis/epidemiology/virology
EDAT- 2012/08/01 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/26 06:00
PHST- 2012/07/26 06:00 [entrez]
PHST- 2012/08/01 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 1439 [pii]
PST - ppublish
SO  - Epidemiol Prev. 2012 May-Aug;36(3-4 Suppl 1):e1-72.


PMID- 22827349
OWN - NLM
STAT- MEDLINE
DCOM- 20130110
LR  - 20181201
IS  - 1439-0531 (Electronic)
IS  - 0936-6768 (Linking)
VI  - 47 Suppl 4
DP  - 2012 Aug
TI  - Ethics, politics and protests: using contentious issues in reproductive sciences 
      as educational opportunities.
PG  - 46-51
LID - 10.1111/j.1439-0531.2012.02054.x [doi]
AB  - Contentious issues and polarized viewpoints can be utilized in the classroom and 
      beyond to create a reflective dialogue among students and citizens. This dialogue
      leads to both a greater understanding, as well as an enhanced appreciation of
      alternative viewpoints. Exploring and discussing the scientific, ethical, moral, 
      political, legal and societal aspects of contentious issues of human reproduction
      provides ideal subject matter for developing critical thinking skills in the
      field of reproductive science.
CI  - (c) 2012 Blackwell Verlag GmbH.
FAU - Knight, J W
AU  - Knight JW
AD  - Department of Animal and Poultry Sciences, Virginia Tech, Blacksburg, VA, USA.
      knight@vt.edu
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Reprod Domest Anim
JT  - Reproduction in domestic animals = Zuchthygiene
JID - 9015668
RN  - 0 (Indoles)
RN  - 0 (Pyrroles)
RN  - V99T50803M (Sunitinib)
SB  - IM
MH  - Bioethical Issues/*standards
MH  - Bioethics/*education
MH  - Curriculum
MH  - Humans
MH  - Indoles
MH  - *Politics
MH  - Problem Solving
MH  - Pyrroles
MH  - Sunitinib
MH  - Thinking
MH  - Universities
EDAT- 2012/08/01 06:00
MHDA- 2013/01/11 06:00
CRDT- 2012/07/26 06:00
PHST- 2012/07/26 06:00 [entrez]
PHST- 2012/08/01 06:00 [pubmed]
PHST- 2013/01/11 06:00 [medline]
AID - 10.1111/j.1439-0531.2012.02054.x [doi]
PST - ppublish
SO  - Reprod Domest Anim. 2012 Aug;47 Suppl 4:46-51. doi:
      10.1111/j.1439-0531.2012.02054.x.


PMID- 22810456
OWN - NLM
STAT- MEDLINE
DCOM- 20121003
LR  - 20160512
IS  - 1535-1386 (Electronic)
IS  - 0021-9355 (Linking)
VI  - 94 Suppl 1
DP  - 2012 Jul 18
TI  - Global randomized trials: the promise of India and China.
PG  - 92-6
LID - 10.2106/JBJS.L.00274 [doi]
AB  - Although modern clinical trials are traditionally conducted in Western countries,
      currently there is a shift to involve developing countries, particularly China
      and India. For these trials, the large population size of India and China means
      that substantial numbers of individuals affected by rare diseases may be found,
      increasing the likelihood of successfully completing enrollment in a clinical
      trial. Furthermore, the increasing involvement of Asian countries in global
      clinical trials is likely to lead to greater appreciation of the value of
      evidence-based treatment decisions in the region. These sites are more
      cost-effective, although this advantage is being eroded over time. Asian
      participants in clinical trials are also typically more likely to complete study 
      follow-up and procedures, and to adhere to their randomized treatment allocation 
      than individuals from Western countries. Challenges include relevance of the
      proposed trial to the region, capacity limitations because of undeveloped
      training, and ensuring research implementation quality and different intellectual
      property practices. There are specific challenges to conducting clinical trials
      in India, such as the status of ethics committees, health insurance and coverage 
      for participants, and variability in languages and record-keeping. Challenges in 
      both countries are substantial but are able to be managed with appropriate
      planning.
FAU - Perkovic, Vlado
AU  - Perkovic V
AD  - The George Institute for Global Health, PO Box M201, Missenden Road, Sydney 2050,
      Australia. vperkovic@thegeorgeinstitute.org
FAU - Patil, Vinodvenkatesh
AU  - Patil V
FAU - Wei, Liu
AU  - Wei L
FAU - Lv, Jicheng
AU  - Lv J
FAU - Petersen, Marisa
AU  - Petersen M
FAU - Patel, Anushka
AU  - Patel A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Bone Joint Surg Am
JT  - The Journal of bone and joint surgery. American volume
JID - 0014030
SB  - IM
MH  - China
MH  - Cost-Benefit Analysis
MH  - *Developing Countries
MH  - Humans
MH  - India
MH  - *International Cooperation
MH  - *Orthopedic Procedures
MH  - Patient Compliance
MH  - *Patient Selection
MH  - Randomized Controlled Trials as Topic/economics/standards/*trends
MH  - Reference Standards
MH  - Sample Size
EDAT- 2012/08/01 06:00
MHDA- 2012/10/04 06:00
CRDT- 2012/07/20 06:00
PHST- 2012/07/20 06:00 [entrez]
PHST- 2012/08/01 06:00 [pubmed]
PHST- 2012/10/04 06:00 [medline]
AID - 1216252 [pii]
AID - 10.2106/JBJS.L.00274 [doi]
PST - ppublish
SO  - J Bone Joint Surg Am. 2012 Jul 18;94 Suppl 1:92-6. doi: 10.2106/JBJS.L.00274.


PMID- 22810449
OWN - NLM
STAT- MEDLINE
DCOM- 20121003
LR  - 20160512
IS  - 1535-1386 (Electronic)
IS  - 0021-9355 (Linking)
VI  - 94 Suppl 1
DP  - 2012 Jul 18
TI  - The dangers of stopping a trial too early.
PG  - 56-60
LID - 10.2106/JBJS.K.01412 [doi]
AB  - To ensure that participants in randomized controlled trials are protected from
      harm, interim analyses and review of results by an independent data monitoring
      committee have become standard practice. If an analysis of accumulating data
      partway through a trial reveals an unanticipated degree of benefit or toxicity,
      or differences in outcomes between the intervention and control groups are so
      unimpressive that any prospect of a positive result with the planned sample size 
      is extremely unlikely, investigators may stop the trial earlier than originally
      scheduled. The practice of stopping randomized controlled trials early is,
      however, problematic, especially if the trial is stopped for apparent benefit.
      Concerns in trials stopped early for apparent benefit include appropriate
      interpretation of results and ethical problems concerning trial participants,
      clinicians, and society as a whole. In this article, we review the epidemiology
      of trials stopped early and illustrate some of the problems and controversies
      associated with stopping randomized controlled trials early for apparent benefit.
      Finally, we offer guidance for clinicians, those running clinical trials, and
      authors of systematic reviews.
FAU - Briel, Matthias
AU  - Briel M
AD  - Mayo Clinic, Rochester, Minnesota 55905, USA.
FAU - Bassler, Dirk
AU  - Bassler D
FAU - Wang, Amy T
AU  - Wang AT
FAU - Guyatt, Gordon H
AU  - Guyatt GH
FAU - Montori, Victor M
AU  - Montori VM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Bone Joint Surg Am
JT  - The Journal of bone and joint surgery. American volume
JID - 0014030
SB  - IM
MH  - *Early Termination of Clinical Trials/ethics/statistics & numerical data
MH  - Humans
MH  - *Randomized Controlled Trials as Topic
EDAT- 2012/08/01 06:00
MHDA- 2012/10/04 06:00
CRDT- 2012/07/20 06:00
PHST- 2012/07/20 06:00 [entrez]
PHST- 2012/08/01 06:00 [pubmed]
PHST- 2012/10/04 06:00 [medline]
AID - 1216244 [pii]
AID - 10.2106/JBJS.K.01412 [doi]
PST - ppublish
SO  - J Bone Joint Surg Am. 2012 Jul 18;94 Suppl 1:56-60. doi: 10.2106/JBJS.K.01412.


PMID- 22810439
OWN - NLM
STAT- MEDLINE
DCOM- 20121003
LR  - 20160512
IS  - 1535-1386 (Electronic)
IS  - 0021-9355 (Linking)
VI  - 94 Suppl 1
DP  - 2012 Jul 18
TI  - Ethical issues in the design of randomized trials: to sham or not to sham.
PG  - 7-10
LID - 10.2106/JBJS.L.00298 [doi]
AB  - The placebo effect is based on the expectations of the patient regarding the
      effectiveness of the treatment. The high levels of stress and rituals involved
      with surgery can lead to a strong placebo effect. However, the ethical principles
      of performing sham surgery to measure any placebo effect have been questioned,
      and sham-controlled surgical trials are rarely conducted. While there are a
      number of ethical principles that must be considered to justify the
      implementation of a sham-controlled surgical clinical trial, four areas deserve
      particular attention: equipoise, risk minimization, informed consent, and
      deception. Particularly in orthopaedics, where equipoise is common,
      sham-controlled trials may be important to ensure that inferior or ineffective
      treatments do not become standard practice.
FAU - Dowrick, Adam S
AU  - Dowrick AS
AD  - McMaster University, Hamilton, Ontario, Canada. a.dowrick@alfred.org.au
FAU - Bhandari, Mohit
AU  - Bhandari M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Bone Joint Surg Am
JT  - The Journal of bone and joint surgery. American volume
JID - 0014030
RN  - 0 (Placebos)
SB  - IM
MH  - Humans
MH  - Informed Consent/ethics
MH  - *Orthopedic Procedures/ethics
MH  - Physician-Patient Relations/ethics
MH  - Placebo Effect
MH  - *Placebos
MH  - Randomized Controlled Trials as Topic/*ethics
MH  - Risk Management/ethics
MH  - Therapeutic Equipoise
EDAT- 2012/08/01 06:00
MHDA- 2012/10/04 06:00
CRDT- 2012/07/20 06:00
PHST- 2012/07/20 06:00 [entrez]
PHST- 2012/08/01 06:00 [pubmed]
PHST- 2012/10/04 06:00 [medline]
AID - 1216247 [pii]
AID - 10.2106/JBJS.L.00298 [doi]
PST - ppublish
SO  - J Bone Joint Surg Am. 2012 Jul 18;94 Suppl 1:7-10. doi: 10.2106/JBJS.L.00298.


PMID- 30082981
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 0024-3639 (Print)
IS  - 0024-3639 (Linking)
VI  - 79
IP  - 3
DP  - 2012 Aug
TI  - Health Care Reform and the Catholic Perspective: The Catholic Medical Association
      Position().
PG  - 334-337
LID - 10.1179/002436312804872677 [doi]
AB  - The Patient Protection and Affordable Care Act is a U.S. federal statute signed
      into law by President Barack Obama on March 23, 2010. It is the principal
      health-care reform legislation of the 111th U.S. Congress. It reforms certain
      aspects of the private health insurance industry and public health insurance
      programs, increases insurance coverage of preexisting conditions, expands access 
      to insurance to over thirty million Americans, and increases projected national
      medical spending while lowering projected Medicare spending. It is expected that 
      each of these promises has or will be broken. The Catholic Medical Association,
      representing Catholic physicians as well as other concerned Catholic health-care 
      professionals, has and will continue to focus on the harm that such a vast, vague
      legislation brings to the task of ongoing moral and ethical delivery of health
      care.
FAU - Breschi, Louis C
AU  - Breschi LC
AD  - Catholic Medical Association.
LA  - eng
PT  - Journal Article
DEP - 20120801
PL  - United States
TA  - Linacre Q
JT  - The Linacre quarterly
JID - 2985221R
PMC - PMC6027035
EDAT- 2012/08/01 00:00
MHDA- 2012/08/01 00:01
CRDT- 2018/08/08 06:00
PHST- 2018/08/08 06:00 [entrez]
PHST- 2012/08/01 00:00 [pubmed]
PHST- 2012/08/01 00:01 [medline]
AID - 10.1179/002436312804872677 [doi]
AID - 10.1179_002436312804872677 [pii]
PST - ppublish
SO  - Linacre Q. 2012 Aug;79(3):334-337. doi: 10.1179/002436312804872677. Epub 2012 Aug
      1.


PMID- 30082975
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 0024-3639 (Print)
IS  - 0024-3639 (Linking)
VI  - 79
IP  - 3
DP  - 2012 Aug
TI  - What Do Medical Students Think about Medical Ethics? UIC-COM Student Medical
      Ethics Questionnaire.
PG  - 275-281
LID - 10.1179/002436312804872703 [doi]
AB  - Medical ethics should be an important aspect of the education of every medical
      student. But do students appreciate or even pay much attention to medical ethics?
      In an effort to address this question, we assessed, by questionnaire, the
      opinions of the students of the largest medical school in the United States (the 
      University of Illinois-College of Medicine) regarding a variety of ethical
      problems. In general, the students were knowledgeable about the issues discussed 
      and expressed ethical concerns about these clinical matters.
FAU - Bamberger, Brian
AU  - Bamberger B
AD  - University of Illinois College of Medicine at Chicago.
FAU - Guinan, Patrick
AU  - Guinan P
AD  - Catholic Physicians Guild of Chicago.
LA  - eng
PT  - Journal Article
DEP - 20120801
PL  - United States
TA  - Linacre Q
JT  - The Linacre quarterly
JID - 2985221R
PMC - PMC6027039
EDAT- 2012/08/01 00:00
MHDA- 2012/08/01 00:01
CRDT- 2018/08/08 06:00
PHST- 2018/08/08 06:00 [entrez]
PHST- 2012/08/01 00:00 [pubmed]
PHST- 2012/08/01 00:01 [medline]
AID - 10.1179/002436312804872703 [doi]
AID - 10.1179_002436312804872703 [pii]
PST - ppublish
SO  - Linacre Q. 2012 Aug;79(3):275-281. doi: 10.1179/002436312804872703. Epub 2012 Aug
      1.


PMID- 29768797
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1744-828X (Electronic)
IS  - 1741-0541 (Linking)
VI  - 9
IP  - 6
DP  - 2012 Aug
TI  - Genetics, genomics and society: the responsibilities of scientists for science
      communication and education.
PG  - 633-643
LID - 10.2217/pme.12.69 [doi]
AB  - Misconceptions about genetics and genomics, such as notions of genetic
      determinism and the existence of 'genes for' particular traits, are widespread
      both in educational contexts and in the public perception of genetics and
      genomics. Owing to such misunderstandings, the prospect of personalized medicine 
      often raises concerns with the general public about possible adverse societal
      consequences of the technologies that are implemented. Among the questions that
      are to be addressed in this context are: to what extent is personalized medical
      treatment possible? Does it require access to sensitive personal data? Who should
      be given such access? What other ethical issues might be raised by personalized
      medicine? How could these be answered? We argue that scientists have a
      professional responsibility to effectively communicate current knowledge and
      views about potential applications to the public in order to better address and
      resolve such issues.
FAU - Reydon, Thomas Ac
AU  - Reydon TA
AD  - Leibniz Universitat Hannover, Institute of Philosophy, Hannover, Germany.
FAU - Kampourakis, Kostas
AU  - Kampourakis K
AD  - GEITONAS School, Secretariat of Educational Research & Development, Athens,
      Greece.
FAU - Patrinos, George P
AU  - Patrinos GP
AD  - University of Patras, School of Health Sciences, Department of Pharmacy,
      University Campus, Rion, GR26504, Patras, Greece. gpatrinos@upatras.gr.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Per Med
JT  - Personalized medicine
JID - 101238549
OTO - NOTNLM
OT  - ethics
OT  - genetics education
OT  - misconceptions
OT  - pharmacogenomics
OT  - responsible science
OT  - science communication
OT  - science education
EDAT- 2012/08/01 00:00
MHDA- 2012/08/01 00:01
CRDT- 2018/05/18 06:00
PHST- 2018/05/18 06:00 [entrez]
PHST- 2012/08/01 00:00 [pubmed]
PHST- 2012/08/01 00:01 [medline]
AID - 10.2217/pme.12.69 [doi]
PST - ppublish
SO  - Per Med. 2012 Aug;9(6):633-643. doi: 10.2217/pme.12.69.


PMID- 27708461
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220310
IS  - 0038-0385 (Print)
IS  - 0038-0385 (Linking)
VI  - 46
IP  - 4
DP  - 2012 Aug
TI  - Ethical boundary-work in the animal research laboratory.
PG  - 649-663
AB  - The use of animals in scientific experiments continues to attract significant
      controversy, particularly in the UK. This article draws on in-depth interviews
      with senior laboratory scientists who use animals in their research. A key claim 
      is that animal research is necessary for medical advance. However, this
      promissory discourse relies on the construction of three boundaries. The first is
      between humans and non-human animals. The second is between the positive and less
      positive impacts of Home Office regulation. The third is between the use of
      animals in medicine versus other domains such as farming. The article analyses
      these discourses and evaluates the applicability of 'ethical boundary-work'
      (Wainwright et al., 2006a). I conclude that the concept is a potentially useful
      device for foregrounding ethics but argue that it carries several dangers for
      sociologists interested in claim-making in areas of controversy.
FAU - Hobson-West, Pru
AU  - Hobson-West P
AD  - University of Nottingham, UK.
LA  - eng
GR  - 078876/Wellcome Trust/United Kingdom
GR  - United Kingdom Wellcome Trust
PT  - Journal Article
PL  - England
TA  - Sociology
JT  - Sociology
JID - 0123003
PMC - PMC5047351
MID - EMS69912
OTO - NOTNLM
OT  - animals
OT  - boundary-work
OT  - ethics
OT  - laboratory
OT  - science
EDAT- 2012/08/01 00:00
MHDA- 2012/08/01 00:01
CRDT- 2016/10/07 06:00
PHST- 2016/10/07 06:00 [entrez]
PHST- 2012/08/01 00:00 [pubmed]
PHST- 2012/08/01 00:01 [medline]
AID - 10.1177/0038038511435058 [doi]
PST - ppublish
SO  - Sociology. 2012 Aug;46(4):649-663. doi: 10.1177/0038038511435058.


PMID- 25610218
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150122
LR  - 20200930
IS  - 1308-8734 (Print)
IS  - 1308-8734 (Linking)
VI  - 44
IP  - 2
DP  - 2012 Aug
TI  - Comparison of esmolol to nitroglycerine in controlling hypotension during nasal
      surgery.
PG  - 99-105
LID - 10.5152/eajm.2012.23 [doi]
AB  - OBJECTIVE: The aim of this study was to compare esmolol to nitroglycerine in
      terms of effectiveness in controlling hypotension during nasal surgery. MATERIALS
      AND METHODS: After approval by our institutional Ethics Committee, 40 patients
      were recruited and randomized into two drug groups: esmolol (Group E) and
      nitroglycerine (Group N). In group E, a bolus dose of 500 mug/kg esmolol was
      administered over 30 sec followed by continuous administration at a dose of
      25-300 mug/ kg/min to maintain systolic arterial pressure at 80 mmHg. In group N,
      nitroglycerine was administered at a dose of 0.5-2 mug/kg/min. RESULTS: During
      the hypotensive period, systolic arterial pressure, diastolic arterial pressure, 
      mean arterial pressure, and heart rate were decreased 24%, 33%, 27% and 35%,
      respectively, in group E (p<0.001, p<0.001, p<0.001, p<0.001) and were decreased 
      30%, 33%, 34% and 23%, respectively, in group N (p<0.001, p<0.001, p<0.001,
      p<0.001). The decrease in heart rate was higher in group E during the hypotensive
      period (p=0.048). During the recovery period, diastolic arterial pressure and
      heart rate were decreased 9% and 18%, respectively, in group E (p=0.044,
      p<0.001). Systolic arterial pressure, diastolic arterial pressure, and mean
      arterial pressure were decreased 7%, 3% and 7%, respectively, in group N
      (p=0.049, p=0.451, p=0.045). CONCLUSION: Esmolol provides hemodynamic stability
      and good surgical field visibility and should be considered as an alternative to 
      nitroglycerine.
FAU - Guney, Ayla
AU  - Guney A
AD  - Department of Anesthesiology and Reanimation, Faculty of Medicine, Uludag
      University, Bursa, Turkey.
FAU - Kaya, Fatma Nur
AU  - Kaya FN
AD  - Department of Anesthesiology and Reanimation, Faculty of Medicine, Uludag
      University, Bursa, Turkey.
FAU - Yavascaoglu, Belgin
AU  - Yavascaoglu B
AD  - Department of Anesthesiology and Reanimation, Faculty of Medicine, Uludag
      University, Bursa, Turkey.
FAU - Gurbet, Alp
AU  - Gurbet A
AD  - Department of Anesthesiology and Reanimation, Faculty of Medicine, Uludag
      University, Bursa, Turkey.
FAU - Selmi, Nazan Has
AU  - Selmi NH
AD  - Department of Anesthesiology and Reanimation, Faculty of Medicine, Uludag
      University, Bursa, Turkey.
FAU - Kaya, Sener
AU  - Kaya S
AD  - Department of Anesthesiology and Reanimation, Faculty of Medicine, Uludag
      University, Bursa, Turkey.
FAU - Kutlay, Oya
AU  - Kutlay O
AD  - Department of Anesthesiology and Reanimation, Faculty of Medicine, Uludag
      University, Bursa, Turkey.
LA  - eng
PT  - Journal Article
PL  - Turkey
TA  - Eurasian J Med
JT  - The Eurasian journal of medicine
JID - 101557701
PMC - PMC4261293
OTO - NOTNLM
OT  - Anesthesia
OT  - Controlled hypotension
OT  - Esmolol hydrochloride
OT  - Nitroglycerin
EDAT- 2012/08/01 00:00
MHDA- 2012/08/01 00:01
CRDT- 2015/01/23 06:00
PHST- 2011/12/30 00:00 [received]
PHST- 2012/04/09 00:00 [accepted]
PHST- 2015/01/23 06:00 [entrez]
PHST- 2012/08/01 00:00 [pubmed]
PHST- 2012/08/01 00:01 [medline]
AID - 10.5152/eajm.2012.23 [doi]
AID - eajm-44-2-99 [pii]
PST - ppublish
SO  - Eurasian J Med. 2012 Aug;44(2):99-105. doi: 10.5152/eajm.2012.23.


PMID- 24849884
OWN - NLM
STAT- MEDLINE
DCOM- 20150109
LR  - 20160511
IS  - 1947-5543 (Electronic)
IS  - 1947-5543 (Linking)
VI  - 10
IP  - 4
DP  - 2012 Aug
TI  - Bridging the financial gap through providing contract services: a model for
      publicly funded clinical biobanks.
PG  - 357-60
LID - 10.1089/bio.2012.0009 [doi]
AB  - Biobanks offer translational researchers a novel method of obtaining clinical
      research materials, patient data, and relevant ethical and legal permissions.
      However, such tissue collections are expensive to establish and maintain. Current
      opinion is that such initiatives can only survive with core funding from
      Government or major funding bodies. Given the present climate of financial
      austerity, funding agencies may be tempted to invest in fast-return research
      projects rather than in maintaining tissue collections, whose benefits will only 
      become apparent in much longer timescales. Thus, securing additional funding for 
      biobanks could provide a valuable boost enabling an extension of core services.
      Here we suggest that using biobank expertise to offer contract services to
      clinicians and industry may be an alternative approach to obtaining such extra
      funding.
FAU - Kozlakidis, Zisis
AU  - Kozlakidis Z
AD  - 1 Department of Infectious Diseases, King's College London, Guy's Hospital ,
      London, United Kingdom .
FAU - Mant, Christine
AU  - Mant C
FAU - Cason, John
AU  - Cason J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biopreserv Biobank
JT  - Biopreservation and biobanking
JID - 101507284
SB  - IM
MH  - Biological Specimen Banks/*economics
MH  - Contract Services/*economics
MH  - Financial Management
EDAT- 2012/08/01 00:00
MHDA- 2015/01/13 06:00
CRDT- 2014/05/23 06:00
PHST- 2014/05/23 06:00 [entrez]
PHST- 2012/08/01 00:00 [pubmed]
PHST- 2015/01/13 06:00 [medline]
AID - 10.1089/bio.2012.0009 [doi]
PST - ppublish
SO  - Biopreserv Biobank. 2012 Aug;10(4):357-60. doi: 10.1089/bio.2012.0009.


PMID- 22844342
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2012
DP  - 2012
TI  - Effectiveness of Mentha piperita in the Treatment of Infantile Colic: A Crossover
      Study.
PG  - 981352
LID - 10.1155/2012/981352 [doi]
AB  - Background. Infantile colic is a distressing and common condition for which there
      is no proven standard treatment. Objective. To compare the efficacy of Mentha
      piperita with simethicone in treatment for infantile colic. Methods. A
      double-blind crossover study was performed with 30 infants attending IMIP,
      Recife, Brazil. They were randomized to use Mentha piperita or simethicone in the
      treatment of infantile colic during 7 days with each drug. Primary outcomes were 
      mother_s opinion about responses to the treatment, number of daily episodes of
      colic, and time spent crying, measured by a chronometer. Mann-Whitney and
      chi-square tests were used to compare the results. This study was previously
      approved by the Ethical Committee in Research at IMIP. Results. At baseline daily
      episodes of infantile colic was 3.9 (+/-1.1) and the mean crying time per day was
      192 minutes (+/-51.6). At the end of the study daily episodes of colic fell to
      1.6 (+/-0.6) and the crying duration decreased to 111 (+/-28) minutes. All
      mothers reported decrease of frequency and duration of the episodes of infantile 
      colic and there were no differences between responses to Mentha piperita and
      simethicone. Conclusions. These findings suggest that Mentha piperita may be used
      to help control infantile colic. However, these results must be repeated by
      others studies.
FAU - Alves, Joao Guilherme Bezerra
AU  - Alves JG
AD  - Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Rua dos Coelhos,
      301 Boa Vista, 52050-080 Recife, PE, Brazil.
FAU - de Brito, Rita de Cassia Coelho Moraes
AU  - de Brito Rde C
FAU - Cavalcanti, Telma Samila
AU  - Cavalcanti TS
LA  - eng
PT  - Journal Article
DEP - 20120712
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC3403674
EDAT- 2012/07/31 06:00
MHDA- 2012/07/31 06:01
CRDT- 2012/07/31 06:00
PHST- 2012/04/26 00:00 [received]
PHST- 2012/05/25 00:00 [accepted]
PHST- 2012/07/31 06:00 [entrez]
PHST- 2012/07/31 06:00 [pubmed]
PHST- 2012/07/31 06:01 [medline]
AID - 10.1155/2012/981352 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2012;2012:981352. doi: 10.1155/2012/981352.
      Epub 2012 Jul 12.


PMID- 22844030
OWN - NLM
STAT- MEDLINE
DCOM- 20130104
LR  - 20120926
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 10
DP  - 2012 Oct
TI  - Training healthcare professionals as moral case deliberation facilitators:
      evaluation of a Dutch training programme.
PG  - 630-5
AB  - Until recently, moral case deliberation (MCD) sessions have mostly been
      facilitated by external experts, mainly professional ethicists. We have developed
      a train the facilitator programme for healthcare professionals aimed at providing
      them with the competences needed for being an MCD facilitator. In this paper, we 
      present the first results of a study in which we evaluated the programme. We used
      a mixed methods design. One hundred and twenty trained healthcare professionals
      and five trainers from 16 training groups working in different healthcare
      organisations throughout the Netherlands were included. After completion of the
      programme, participants feel sufficiently confident and equipped to facilitate an
      MCD session. Feeling competent does not mean that participants have no doubts or 
      questions left. Rather, they are aware of their limitations and see the need for 
      continuous learning. According to the respondents, the actual exercise of
      facilitating MCD during and in between the training sessions contributed most to 
      the development of competences necessary for being an MCD facilitator.
      Respondents without prior experience of participating in MCD sessions felt less
      competent after the training than those who had participated in MCD sessions
      before. Self-attributed competence varied between participants with different
      professional backgrounds.
FAU - Plantinga, Mirjam
AU  - Plantinga M
AD  - University Medical Center Groningen, Hanzeplein 1, Groningen 9700RB, The
      Netherlands. m.plantinga@umcg.nl
FAU - Molewijk, Bert
AU  - Molewijk B
FAU - de Bree, Menno
AU  - de Bree M
FAU - Moraal, Marloes
AU  - Moraal M
FAU - Verkerk, Marian
AU  - Verkerk M
FAU - Widdershoven, Guy A M
AU  - Widdershoven GA
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20120726
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Adult
MH  - Aged
MH  - Clergy
MH  - Decision Making/*ethics
MH  - Education
MH  - *Educational Measurement
MH  - Female
MH  - Health Personnel/*education
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Morals
MH  - Multivariate Analysis
MH  - Netherlands
MH  - Nurses
MH  - Physicians
MH  - Program Evaluation
MH  - Psychology
MH  - Qualitative Research
MH  - Social Work
EDAT- 2012/07/31 06:00
MHDA- 2013/01/05 06:00
CRDT- 2012/07/31 06:00
PHST- 2012/07/31 06:00 [entrez]
PHST- 2012/07/31 06:00 [pubmed]
PHST- 2013/01/05 06:00 [medline]
AID - medethics-2012-100546 [pii]
AID - 10.1136/medethics-2012-100546 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Oct;38(10):630-5. doi: 10.1136/medethics-2012-100546. Epub
      2012 Jul 26.


PMID- 22844019
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20120730
IS  - 1758-1052 (Electronic)
IS  - 0956-4624 (Linking)
VI  - 23
IP  - 7
DP  - 2012 Jul
TI  - Clinical care versus ethical obligations: HIV-1 and -2 co-infection with
      hepatitis B in a pregnant Jehovah's Witness.
PG  - e5-6
LID - 10.1258/ijsa.2009.009457 [doi]
AB  - Co-infection with HIV-1 and -2 is rare, even in west Africa. We present the case 
      of a 38-year-old pregnant Jehovah's Witness presenting late in pregnancy with
      triple infection with HIV-1, HIV-2 and hepatitis B virus. There was a successful 
      outcome in averting vertical transmission despite objections to management based 
      on religious and cultural beliefs.
FAU - Quinn, K J
AU  - Quinn KJ
AD  - Department of Genito-Urinary and HIV Medicine, Royal Victoria Hospital Belfast,
      Belfast, UK. quinnkj@doctors.org.uk
FAU - McCarty, E J
AU  - McCarty EJ
FAU - Dinsmore, W M
AU  - Dinsmore WM
FAU - Quah, S P
AU  - Quah SP
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Int J STD AIDS
JT  - International journal of STD & AIDS
JID - 9007917
RN  - 0 (Hepatitis B Antibodies)
SB  - IM
MH  - Coinfection/*virology
MH  - Female
MH  - HIV Infections/diagnosis/drug therapy/*virology
MH  - HIV-1/*isolation & purification
MH  - HIV-2/*isolation & purification
MH  - Health Knowledge, Attitudes, Practice
MH  - Hepatitis B Antibodies
MH  - Hepatitis B, Chronic/diagnosis/drug therapy/*virology
MH  - Humans
MH  - *Jehovah's Witnesses
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/*virology
EDAT- 2012/07/31 06:00
MHDA- 2013/02/13 06:00
CRDT- 2012/07/31 06:00
PHST- 2012/07/31 06:00 [entrez]
PHST- 2012/07/31 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
AID - 23/7/e5 [pii]
AID - 10.1258/ijsa.2009.009457 [doi]
PST - ppublish
SO  - Int J STD AIDS. 2012 Jul;23(7):e5-6. doi: 10.1258/ijsa.2009.009457.


PMID- 22843768
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20220331
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 265
IP  - 1
DP  - 2012 Oct
TI  - Intravoxel incoherent motion diffusion-weighted imaging in nonalcoholic fatty
      liver disease: a 3.0-T MR study.
PG  - 96-103
AB  - PURPOSE: To compare pure molecular diffusion, D, perfusion-related diffusion, D*,
      and perfusion fraction, f, determined from diffusion-weighted (DW) magnetic
      resonance (MR) imaging on the basis of the intravoxel incoherent motion (IVIM)
      theory in patients with type 2 diabetes with and without liver steatosis.
      MATERIALS AND METHODS: This prospective study was approved by the appropriate
      ethics committee, and written informed consent was obtained from all patients.
      Between December 2009 and September 2011, 108 patients with type 2 diabetes (51
      men, 57 women; mean age, 50 years) underwent 3.0-T single-voxel point-resolved
      proton MR spectroscopy of the liver (segment VII) to calculate the liver fat
      fraction from water (4.76 ppm) and methylene (1.33 ppm) peaks, corrected for T1
      and T2 decay. Steatosis was defined as a liver fat fraction of at least 5.56%. DW
      imaging was performed by using a single-shot echo-planar sequence with 11 b
      values (0, 5, 15, 25, 35, 50, 100, 200, 400, 600, 800 sec/mm2). Liver D, D*, and 
      f were measured and compared in patients with and patients without steatosis
      (Mann-Whitney test). RESULTS: The mean liver fat fraction was 7.8% (standard
      deviation, 9%; range, 0.99%-45%). Forty patients had liver steatosis. D was
      significantly lower in steatotic compared with nonsteatotic livers (mean,
      1.03x10(-3) mm2/sec+/-0.23 [standard deviation] vs 1.24x10(-3) mm2/sec+/-0.15,
      respectively; P<.0001), as was D* (mean, 72.2x10(-3) mm2/sec+/-61.4 vs
      110.6x10(-3) mm2/sec+/-79; P=.0025). However, f was significantly higher in
      steatotic compared with nonsteatotic livers (mean, 33.8%+/-9.4 vs 26.9%+/-8.8;
      P=.0003). CONCLUSION: D is significantly decreased in steatosis. The reduction in
      D* reflects decreased liver parenchymal perfusion in steatosis. Therefore,
      steatosis can affect diffusion parameters obtained with IVIM.
CI  - (c) RSNA, 2012.
FAU - Guiu, Boris
AU  - Guiu B
AD  - University of Burgundy, INSERM U866, Department of Endocrinology, Diabetology,
      and Metabolic Diseases, CHU University Hospital, Dijon, France.
      Boris.guiu@chu-dijon.fr
FAU - Petit, Jean-Michel
AU  - Petit JM
FAU - Capitan, Violaine
AU  - Capitan V
FAU - Aho, Serge
AU  - Aho S
FAU - Masson, David
AU  - Masson D
FAU - Lefevre, Pierre-Henri
AU  - Lefevre PH
FAU - Favelier, Sylvain
AU  - Favelier S
FAU - Loffroy, Romaric
AU  - Loffroy R
FAU - Verges, Bruno
AU  - Verges B
FAU - Hillon, Patrick
AU  - Hillon P
FAU - Krause, Denis
AU  - Krause D
FAU - Cercueil, Jean-Pierre
AU  - Cercueil JP
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20120727
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/analysis
MH  - Diabetes Mellitus, Type 2/*pathology
MH  - Diffusion Magnetic Resonance Imaging/methods
MH  - Fatty Liver/*pathology
MH  - Female
MH  - Humans
MH  - Linear Models
MH  - Magnetic Resonance Spectroscopy/*methods
MH  - Male
MH  - Middle Aged
MH  - Non-alcoholic Fatty Liver Disease
MH  - Prospective Studies
MH  - Statistics, Nonparametric
EDAT- 2012/07/31 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/31 06:00
PHST- 2012/07/31 06:00 [entrez]
PHST- 2012/07/31 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - radiol.12112478 [pii]
AID - 10.1148/radiol.12112478 [doi]
PST - ppublish
SO  - Radiology. 2012 Oct;265(1):96-103. doi: 10.1148/radiol.12112478. Epub 2012 Jul
      27.


PMID- 22843767
OWN - NLM
STAT- MEDLINE
DCOM- 20130103
LR  - 20220317
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 265
IP  - 2
DP  - 2012 Nov
TI  - Prostate cancer aggressiveness: in vivo assessment of MR spectroscopy and
      diffusion-weighted imaging at 3 T.
PG  - 457-67
LID - 10.1148/radiol.12111744 [doi]
AB  - PURPOSE: To determine the individual and combined performance of magnetic
      resonance (MR) spectroscopic imaging and diffusion-weighted (DW) imaging at 3 T
      in the in vivo assessment of prostate cancer aggressiveness by using
      histopathologically defined regions of interest on radical prostatectomy
      specimens to define the prostate cancer regions to be investigated. MATERIALS AND
      METHODS: The local institutional ethics review board approved this retrospective 
      study and waived the informed consent requirement. Fifty-four patients with
      biopsy-proved prostate cancer underwent clinical MR spectroscopic imaging
      followed by prostatectomy. Guided by the histopathologic map, all spectroscopy
      voxels that contained tumor tissue were selected, and metabolite ratios (choline 
      [Cho] plus creatine [Cr]-to-citrate [Cit] and Cho/Cr ratios) were derived. For
      each spectroscopic voxel, 25th percentile apparent diffusion coefficient (ADC) of
      the region corresponding to that voxel was determined, representing the most
      aberrant tumor part on the ADC map, which was often smaller than spectroscopic
      imaging voxels. Maximum metabolic ratios and minimum 25th percentile ADC of each 
      tumor were related to tumor aggressiveness and were used to differentiate
      aggressiveness classes. A logistic regression model (LRM) was used to combine
      data from both modalities. RESULTS: Significant correlation was found between
      aggressiveness classes and maximum Cho+Cr/Cit ratio (rho=0.36), maximum Cho/Cr
      ratio (rho=0.35), and minimum 25th percentile ADC (rho=-0.63) in the peripheral
      zone (PZ). In the transition zone (TZ), the correlation was significant for only 
      Cho+Cr/Cit and Cho/Cr ratios (rho=0.58 and rho=0.60, respectively). For
      differentiation between aggressiveness classes, LRM use did not result in
      significantly improved differentiation over any individual variables. CONCLUSION:
      These findings enabled confirmation that MR spectroscopic imaging and DW imaging 
      offer potential for in vivo noninvasive assessment of prostate cancer
      aggressiveness, and both modalities have comparable performance. The combination 
      did not result in better performance. Nonetheless, the better performances of
      metabolite ratios in the TZ and of ADCs in the PZ suggest that they have
      complementary value.
CI  - (c) RSNA, 2012
FAU - Kobus, Thiele
AU  - Kobus T
AD  - Department of Radiology, Radboud University Nijmegen Medical Centre, Geert
      Grooteplein 10, 6525GA Nijmegen, the Netherlands. T.Kobus@rad.umcn.nl
FAU - Vos, Pieter C
AU  - Vos PC
FAU - Hambrock, Thomas
AU  - Hambrock T
FAU - De Rooij, Maarten
AU  - De Rooij M
FAU - Hulsbergen-Van de Kaa, Christina A
AU  - Hulsbergen-Van de Kaa CA
FAU - Barentsz, Jelle O
AU  - Barentsz JO
FAU - Heerschap, Arend
AU  - Heerschap A
FAU - Scheenen, Tom W J
AU  - Scheenen TW
LA  - eng
GR  - 243115/ERC_/European Research Council/International
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120727
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Protons)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/*analysis
MH  - Diffusion Magnetic Resonance Imaging/*methods
MH  - Humans
MH  - Magnetic Resonance Spectroscopy/*methods
MH  - Male
MH  - Middle Aged
MH  - Molecular Imaging/*methods
MH  - Neoplasm Invasiveness
MH  - Prostatic Neoplasms/*metabolism/*pathology
MH  - Protons
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
EDAT- 2012/07/31 06:00
MHDA- 2013/01/04 06:00
CRDT- 2012/07/31 06:00
PHST- 2012/07/31 06:00 [entrez]
PHST- 2012/07/31 06:00 [pubmed]
PHST- 2013/01/04 06:00 [medline]
AID - radiol.12111744 [pii]
AID - 10.1148/radiol.12111744 [doi]
PST - ppublish
SO  - Radiology. 2012 Nov;265(2):457-67. doi: 10.1148/radiol.12111744. Epub 2012 Jul
      27.


PMID- 22843765
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 265
IP  - 1
DP  - 2012 Oct
TI  - US assessment of medial arterial calcification: a sensitive marker of
      diabetes-related microvascular and macrovascular complications.
PG  - 294-302
AB  - PURPOSE: To examine the sensitivity of ultrasonography (US) compared with
      conventional radiography in detection of lower limb (thigh) medial arterial
      calcification (MAC) in type 2 diabetic patients and evaluate its association with
      diabetes-related complications. MATERIALS AND METHODS: The study was approved by 
      the local research ethics committee, and informed written consent was obtained.
      US was performed in 289 patients with type 2 diabetes mellitus, and MAC severity 
      was assigned a score from 0 to 8. Among the patients, 263 underwent radiographic 
      examinations. All subjects underwent clinical evaluation to detect the presence
      of diabetes-related complications. RESULTS: US helped detect MAC in more subjects
      compared with radiography (65.8% vs 12.2%). US helped detect MAC from mild
      (scores 1-4) to severe (scores 5-8) degrees, while mild degree of MAC was poorly 
      demonstrated with radiography. The incidence of nephropathy, retinopathy, sensory
      neuropathy, and macrovascular complications increased with the severity of MAC
      (based on US scoring). With univariate analysis, the presence of MAC was
      associated with nephropathy (P<.001), retinopathy (P<.001), sensory neuropathy
      (P=.004), and macrovascular complications (P<.001). After adjustment for
      potential confounders, the presence of severe MAC was associated with
      nephropathy, retinopathy, and macrovascular complications, with the odds ratios
      of 3.4 (95% confidence interval [CI]: 1.53, 7.43; P=.003), 2.6 (95% CI: 1.22,
      5.32; P=.013), and 3.8 (95% CI: 1.37, 10.6; P=.01), respectively. CONCLUSION: In 
      type 2 diabetic Chinese patients, US was more sensitive than conventional
      radiography in the detection of MAC, particularly when the MAC was mild. The
      presence of severe MAC was associated with diabetic nephropathy, retinopathy, and
      macrovascular complications. US detection of MAC was a potential early marker to 
      identify diabetes-related complications.
CI  - (c) RSNA, 2012.
FAU - Liu, Kin Hung
AU  - Liu KH
AD  - Department of Diagnostic Imaging and Interventional Radiology, the Chinese
      University of Hong Kong, Prince of Wales Hospital, 30-32 Ngan Shing St, Shatin,
      NT, Hong Kong SAR, China.
FAU - Chu, Winnie Chiu Wing
AU  - Chu WC
FAU - Kong, Alice Pik Shan
AU  - Kong AP
FAU - Choi Ko, Gary Tin
AU  - Choi Ko GT
FAU - Ma, Ronald Ching Wan
AU  - Ma RC
FAU - Chan, Jeff Wai Sang
AU  - Chan JW
FAU - Chow, Louis T C
AU  - Chow LT
FAU - Rasalkar, Darshana D
AU  - Rasalkar DD
FAU - So, Wing Yee
AU  - So WY
FAU - Tse, Lung Fung
AU  - Tse LF
FAU - Corcoran, Heidi Samantha
AU  - Corcoran HS
FAU - Ozaki, Risa
AU  - Ozaki R
FAU - Ahuja, Anil T
AU  - Ahuja AT
FAU - Chan, Juliana Chung Ngor
AU  - Chan JC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20120727
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Angiography/methods
MH  - Chi-Square Distribution
MH  - Diabetes Mellitus, Type 2/diagnostic imaging
MH  - Diabetic Angiopathies/*diagnostic imaging
MH  - Female
MH  - Humans
MH  - Leg/*blood supply
MH  - Male
MH  - Middle Aged
MH  - Monckeberg Medial Calcific Sclerosis/*diagnostic imaging
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
MH  - Ultrasonography
EDAT- 2012/07/31 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/31 06:00
PHST- 2012/07/31 06:00 [entrez]
PHST- 2012/07/31 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - radiol.12112440 [pii]
AID - 10.1148/radiol.12112440 [doi]
PST - ppublish
SO  - Radiology. 2012 Oct;265(1):294-302. doi: 10.1148/radiol.12112440. Epub 2012 Jul
      27.


PMID- 22843546
OWN - NLM
STAT- MEDLINE
DCOM- 20130108
LR  - 20220310
IS  - 1535-1645 (Electronic)
IS  - 1523-3812 (Linking)
VI  - 14
IP  - 5
DP  - 2012 Oct
TI  - Attention-deficit/hyperactivity disorder genomics: update for clinicians.
PG  - 579-89
LID - 10.1007/s11920-012-0309-4 [doi]
AB  - Attention deficit, hyperactivity disorder (ADHD) is familial and highly
      heritable. Several candidate genes involved in neurotransmission have been
      identified, however these confer minimal risk, suggesting that for the most part,
      ADHD is not caused by single common genetic variants. Advances in genotyping
      enabling investigation at the level of the genome have led to the discovery of
      rare structural variants suggesting that ADHD is a genomic disorder, with
      potentially thousands of variants, and common neuronal pathways disrupted by
      numerous rare variants resulting in similar ADHD phenotypes. Heritability studies
      in humans also indicate the importance of epigenetic factors, and animal studies 
      are deciphering some of the processes that confer risk during gestation and
      throughout the post-natal period. These and future discoveries will lead to
      improved diagnosis, individualized treatment, cures, and prevention. These
      advances also highlight ethical and legal issues requiring management and
      interpretation of genetic data and ensuring privacy and protection from misuse.
FAU - Elia, Josephine
AU  - Elia J
AD  - Department Psychiatry, The University of Pennsylvania, Philadelphia, PA
      19104-6209, USA. joelia1@verizon.net
FAU - Sackett, Jillan
AU  - Sackett J
FAU - Turner, Terri
AU  - Turner T
FAU - Schardt, Martin
AU  - Schardt M
FAU - Tang, Shih-Ching
AU  - Tang SC
FAU - Kurtz, Nicole
AU  - Kurtz N
FAU - Dunfey, Maura
AU  - Dunfey M
FAU - McFarlane, Nadia A
AU  - McFarlane NA
FAU - Susi, Aita
AU  - Susi A
FAU - Danish, David
AU  - Danish D
FAU - Li, Alice
AU  - Li A
FAU - Nissley-Tsiopinis, Jenelle
AU  - Nissley-Tsiopinis J
FAU - Borgmann-Winter, Karin
AU  - Borgmann-Winter K
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Curr Psychiatry Rep
JT  - Current psychiatry reports
JID - 100888960
SB  - IM
MH  - Attention Deficit Disorder with Hyperactivity/*genetics
MH  - Epigenomics
MH  - Ethics, Medical
MH  - Genetic Predisposition to Disease
MH  - Genetic Variation
MH  - *Genomics/ethics/legislation & jurisprudence
MH  - Genotype
MH  - Humans
MH  - Synaptic Transmission/genetics
EDAT- 2012/07/31 06:00
MHDA- 2013/01/09 06:00
CRDT- 2012/07/31 06:00
PHST- 2012/07/31 06:00 [entrez]
PHST- 2012/07/31 06:00 [pubmed]
PHST- 2013/01/09 06:00 [medline]
AID - 10.1007/s11920-012-0309-4 [doi]
PST - ppublish
SO  - Curr Psychiatry Rep. 2012 Oct;14(5):579-89. doi: 10.1007/s11920-012-0309-4.


PMID- 22843416
OWN - NLM
STAT- MEDLINE
DCOM- 20140520
LR  - 20211021
IS  - 1574-4647 (Electronic)
IS  - 0161-9152 (Linking)
VI  - 35
IP  - 5
DP  - 2013 Oct
TI  - Anti-aging effects of vitamin C on human pluripotent stem cell-derived
      cardiomyocytes.
PG  - 1545-57
LID - 10.1007/s11357-012-9457-z [doi]
AB  - Human pluripotent stem cells (hPSCs) have arisen as a source of cells for
      biomedical research due to their developmental potential. Stem cells possess the 
      promise of providing clinicians with novel treatments for disease as well as
      allowing researchers to generate human-specific cellular metabolism models. Aging
      is a natural process of living organisms, yet aging in human heart cells is
      difficult to study due to the ethical considerations regarding human
      experimentation as well as a current lack of alternative experimental models.
      hPSC-derived cardiomyocytes (CMs) bear a resemblance to human cardiac cells and
      thus hPSC-derived CMs are considered to be a viable alternative model to study
      human heart cell aging. In this study, we used hPSC-derived CMs as an in vitro
      aging model. We generated cardiomyocytes from hPSCs and demonstrated the process 
      of aging in both human embryonic stem cell (hESC)- and induced pluripotent stem
      cell (hiPSC)-derived CMs. Aging in hESC-derived CMs correlated with reduced
      membrane potential in mitochondria, the accumulation of lipofuscin, a slower
      beating pattern, and the downregulation of human telomerase RNA (hTR) and cell
      cycle regulating genes. Interestingly, the expression of hTR in hiPSC-derived CMs
      was not significantly downregulated, unlike in hESC-derived CMs. In order to
      delay aging, vitamin C was added to the cultured CMs. When cells were treated
      with 100 muM of vitamin C for 48 h, anti-aging effects, specifically on the
      expression of telomere-related genes and their functionality in aging cells, were
      observed. Taken together, these results suggest that hPSC-derived CMs can be used
      as a unique human cardiomyocyte aging model in vitro and that vitamin C shows
      anti-aging effects in this model.
FAU - Kim, Yoon Young
AU  - Kim YY
AD  - Institute of Reproductive Medicine and Population, Medical Research Center, Seoul
      National University, Seoul, South Korea.
FAU - Ku, Seung-Yup
AU  - Ku SY
FAU - Huh, Yul
AU  - Huh Y
FAU - Liu, Hung-Ching
AU  - Liu HC
FAU - Kim, Seok Hyun
AU  - Kim SH
FAU - Choi, Young Min
AU  - Choi YM
FAU - Moon, Shin Yong
AU  - Moon SY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120728
PL  - Netherlands
TA  - Age (Dordr)
JT  - Age (Dordrecht, Netherlands)
JID - 101250497
RN  - 0 (Antioxidants)
RN  - 0 (TERF2 protein, human)
RN  - 0 (Telomeric Repeat Binding Protein 2)
RN  - 63231-63-0 (RNA)
RN  - PQ6CK8PD0R (Ascorbic Acid)
SB  - IM
MH  - Aging/*drug effects/genetics/metabolism
MH  - Antioxidants/pharmacology
MH  - Ascorbic Acid/*pharmacology
MH  - Cell Differentiation
MH  - Cell Line
MH  - Follow-Up Studies
MH  - Gene Expression Regulation, Developmental
MH  - Humans
MH  - Microscopy, Electron, Transmission
MH  - Myocytes, Cardiac/*drug effects/metabolism/ultrastructure
MH  - Pluripotent Stem Cells/*drug effects/metabolism/ultrastructure
MH  - RNA/genetics
MH  - Real-Time Polymerase Chain Reaction
MH  - Telomeric Repeat Binding Protein 2/biosynthesis/genetics
PMC - PMC3776090
EDAT- 2012/07/31 06:00
MHDA- 2014/05/21 06:00
CRDT- 2012/07/31 06:00
PHST- 2012/01/19 00:00 [received]
PHST- 2012/07/06 00:00 [accepted]
PHST- 2012/07/31 06:00 [entrez]
PHST- 2012/07/31 06:00 [pubmed]
PHST- 2014/05/21 06:00 [medline]
AID - 10.1007/s11357-012-9457-z [doi]
PST - ppublish
SO  - Age (Dordr). 2013 Oct;35(5):1545-57. doi: 10.1007/s11357-012-9457-z. Epub 2012
      Jul 28.


PMID- 22843338
OWN - NLM
STAT- MEDLINE
DCOM- 20130208
LR  - 20211021
IS  - 1572-8498 (Electronic)
IS  - 0956-2737 (Linking)
VI  - 24
IP  - 3
DP  - 2012 Sep
TI  - Not in isolation: how history can inform the debate on professionalization.
PG  - 165-70
LID - 10.1007/s10730-012-9184-y [doi]
AB  - As ethics services have become more integrated into healthcare organizations, the
      controversy regarding the possible professionalization of healthcare ethics
      practices has re-emerged. Some of the debate focuses on whether healthcare ethics
      practice possesses the attributes of a 'true profession.' This study examines the
      history of the professions and the relevance of this historical material, as well
      as sociological insights, for contemporary concerns. It explores whether the
      mismatch between traditional models of professional knowledge and the knowledge
      foundation for healthcare ethics is at the core of these concerns. It also takes 
      the position that given the role healthcare ethics plays in assisting patients,
      families, healthcare providers, and others with complex moral decisions it is
      important to work towards developing standards that can be used to guide and
      evaluate the work.
FAU - d'Agincourt-Canning, Lori
AU  - d'Agincourt-Canning L
AD  - Department of Pediatrics, University of British Columbia, Ethics Services, BC
      Children's & Women's Health Centre, Vancouver, BC, Canada. ldagincourt@cw.bc.ca
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - Netherlands
TA  - HEC Forum
JT  - HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues
JID - 8917455
MH  - Bioethics
MH  - Ethicists
MH  - History, 16th Century
MH  - History, 17th Century
MH  - History, 18th Century
MH  - History, 19th Century
MH  - History, 20th Century
MH  - Humans
MH  - Professional Competence
MH  - Professional Practice/*history
MH  - Professional Role
EDAT- 2012/07/31 06:00
MHDA- 2013/02/09 06:00
CRDT- 2012/07/31 06:00
PHST- 2012/07/31 06:00 [entrez]
PHST- 2012/07/31 06:00 [pubmed]
PHST- 2013/02/09 06:00 [medline]
AID - 10.1007/s10730-012-9184-y [doi]
PST - ppublish
SO  - HEC Forum. 2012 Sep;24(3):165-70. doi: 10.1007/s10730-012-9184-y.


PMID- 22842440
OWN - NLM
STAT- MEDLINE
DCOM- 20121009
LR  - 20210106
IS  - 1529-4242 (Electronic)
IS  - 0032-1052 (Linking)
VI  - 130
IP  - 2
DP  - 2012 Aug
TI  - Ethics and the limits of science.
PG  - 369e-370e
LID - 10.1097/PRS.0b013e31825900eb [doi]
FAU - Lazzeri, Davide
AU  - Lazzeri D
AD  - Operative Unit of Plastic and Reconstructive Surgery, Hospital of Pisa, Pisa,
      Italy (Lazzeri) Section of Plastic, Aesthetic, and Reconstructive Surgery,
      General Hospital Linz, Linz, Austria (Larcher) Department of Plastic and
      Reconstructive Surgery, University of Tor Vergata, Rome, Italy (Nicoli) Unit of
      Plastic and Reconstructive Surgery and, Unit of Lymphatic Surgery and
      Microsurgery, RCCS University Hospital "San Martino", Genoa, Italy (Campisi)
      Maxillofacial Surgery Unit, Hospital of Florence, Florence, Italy (Agostini).
FAU - Larcher, Lorenz
AU  - Larcher L
FAU - Nicoli, Fabio
AU  - Nicoli F
FAU - Campisi, Corrado
AU  - Campisi C
FAU - Agostini, Tommaso
AU  - Agostini T
LA  - eng
PT  - Letter
PT  - Comment
PL  - United States
TA  - Plast Reconstr Surg
JT  - Plastic and reconstructive surgery
JID - 1306050
SB  - IM
CON - Plast Reconstr Surg. 2011 Oct;128(4):853-9. PMID: 21681128
MH  - Animals
MH  - Female
MH  - Free Tissue Flaps/*innervation
MH  - Male
MH  - Muscle, Skeletal/*surgery
MH  - Reconstructive Surgical Procedures/*methods
MH  - Recovery of Function/*physiology
EDAT- 2012/07/31 06:00
MHDA- 2012/10/10 06:00
CRDT- 2012/07/31 06:00
PHST- 2012/07/31 06:00 [entrez]
PHST- 2012/07/31 06:00 [pubmed]
PHST- 2012/10/10 06:00 [medline]
AID - 10.1097/PRS.0b013e31825900eb [doi]
AID - 00006534-201208000-00115 [pii]
PST - ppublish
SO  - Plast Reconstr Surg. 2012 Aug;130(2):369e-370e. doi:
      10.1097/PRS.0b013e31825900eb.


PMID- 22842374
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20220317
IS  - 1998-4138 (Electronic)
IS  - 1998-4138 (Linking)
VI  - 8
IP  - 2
DP  - 2012 Apr-Jun
TI  - Quality of life assessment in survivors of breast cancer.
PG  - 272-6
LID - 10.4103/0973-1482.98986 [doi]
AB  - AIM: The aim was to assess the health-related quality of life (HRQOL) and its
      temporal variation at first visit and subsequent visits among breast cancer
      patients. DESIGN AND SETTING: The prospective study was carried out in Outpatient
      Department of Radiation Oncology, University Teaching and Tertiary Referral
      Hospital. MATERIAL AND METHODS: After clearance from the ethical committee and
      EORTC group, 81 surgically treated female breast cancer patients referred to the 
      Outpatient Department of Radiation Oncology for chemoradiation and hormonal
      therapy were included in the study after informed written consent, irrespective
      of the age and stage of disease. The patients were interviewed as per the EORTC
      QLQ-C30 Questionnaire module at four levels at the first visit and at subsequent 
      follow-up visits at 6, 12, and 24 months, respectively, and are still on
      follow-up. STATISTICAL ANALYSIS: The data collected were expressed as mean/raw
      score (RS), standard deviation (SD), and percent mean/scale score expressed on
      the linear transformation scale, derived as per the calculations and equations of
      the EORTC QLQ-C30 Scoring Manual. Intragroup comparison (IGC) was done at four
      levels/visits, a, b, c and d. A P-value of <0.05 was considered significant.
      RESULTS: The mean age at presentation was 46.6 +/- 10.2 years. The study showed
      that the physical functioning, role functioning, cognitive functioning, emotional
      functioning, social functioning, global health status, and symptomatology showed 
      statistically significant improvement over time (P < 0.001). CONCLUSION: The
      survivors of female breast cancer over the long-term follow-up showed significant
      improvement and coping mechanisms involved in a majority of HRQOL parameters.
FAU - Wani, Shaqul Qamar
AU  - Wani SQ
AD  - Department of Radiation Oncology, Government Medical College and Associated
      Hospitals, Karan Nagar, Srinagar, India. drsqamar1@gmail.com
FAU - Khan, Talib
AU  - Khan T
FAU - Teeli, Ashraf M
AU  - Teeli AM
FAU - Khan, Nazir A
AU  - Khan NA
FAU - Wani, Saiful Yamin
AU  - Wani SY
CN  - Ashfaq-ul-Hassan
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Cancer Res Ther
JT  - Journal of cancer research and therapeutics
JID - 101249598
SB  - IM
CIN - J Cancer Res Ther. 2013 Oct-Dec;9(4):755-6. PMID: 24518739
CIN - J Cancer Res Ther. 2013 Oct-Dec;9(4):760. PMID: 24518743
MH  - Activities of Daily Living
MH  - Adult
MH  - Affective Symptoms
MH  - Breast Neoplasms/economics/*pathology/psychology
MH  - Cognition
MH  - *Convalescence
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Middle Aged
MH  - Prospective Studies
MH  - *Quality of Life
MH  - Recovery of Function
MH  - Social Behavior
MH  - Surveys and Questionnaires
MH  - *Survivors
MH  - Treatment Outcome
EDAT- 2012/07/31 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/31 06:00
PHST- 2012/07/31 06:00 [entrez]
PHST- 2012/07/31 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - JCanResTher_2012_8_2_272_98986 [pii]
AID - 10.4103/0973-1482.98986 [doi]
PST - ppublish
SO  - J Cancer Res Ther. 2012 Apr-Jun;8(2):272-6. doi: 10.4103/0973-1482.98986.


PMID- 22841411
OWN - NLM
STAT- MEDLINE
DCOM- 20131204
LR  - 20130206
IS  - 1873-6513 (Electronic)
IS  - 0885-3924 (Linking)
VI  - 45
IP  - 2
DP  - 2013 Feb
TI  - Palliative care after attempted suicide in the absence of premorbid terminal
      disease: a case series and review of the literature.
PG  - 305-9
LID - 10.1016/j.jpainsymman.2012.01.008 [doi]
LID - S0885-3924(12)00241-2 [pii]
AB  - Palliative care involvement in the management of incomplete suicide in patients
      without terminal illness is rare. This paper documents two such cases and
      explores some of the clinical and ethical issues raised.
CI  - Crown Copyright (c) 2013. Published by Elsevier Inc. All rights reserved.
FAU - Eastman, Peter
AU  - Eastman P
AD  - Melbourne Health Palliative Care Service, The Royal Melbourne Hospital,
      Parkville, Victoria, Australia. eastman@gmp.usyd.edu.au
FAU - Le, Brian
AU  - Le B
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20120726
PL  - United States
TA  - J Pain Symptom Manage
JT  - Journal of pain and symptom management
JID - 8605836
SB  - IM
MH  - Adult
MH  - Chronic Disease/*nursing
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Palliative Care/*ethics/*methods
MH  - Suicide, Attempted/*ethics/*psychology
MH  - Terminal Care/*ethics/*methods
EDAT- 2012/07/31 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/07/31 06:00
PHST- 2011/10/10 00:00 [received]
PHST- 2012/01/23 00:00 [revised]
PHST- 2012/02/08 00:00 [accepted]
PHST- 2012/07/31 06:00 [entrez]
PHST- 2012/07/31 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - S0885-3924(12)00241-2 [pii]
AID - 10.1016/j.jpainsymman.2012.01.008 [doi]
PST - ppublish
SO  - J Pain Symptom Manage. 2013 Feb;45(2):305-9. doi:
      10.1016/j.jpainsymman.2012.01.008. Epub 2012 Jul 26.


PMID- 22841275
OWN - NLM
STAT- MEDLINE
DCOM- 20130103
LR  - 20120730
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 44
IP  - 6
DP  - 2012 Jul-Aug
TI  - Incentives for organ donation: pros and cons.
PG  - 1793-4
LID - 10.1016/j.transproceed.2012.05.038 [doi]
AB  - Altruism still remains the main principle of organ donation worldwide. However,
      since the current practices has not met the demand for organs, new strategies
      should be found to encourage organ donation. Implementation of financial
      incentives in transplantation is a matter of debate among experts in the fields
      of transplantation, ethics, law, and economics. It should be acknowledged that
      donors incur many expenses while participating in the transplant process, which
      seems unfair. Various forms of incentives have been suggested and are currently
      used worldwide. This article describes current attitudes toward incentives for in
      transplantation used in different countries, arguing in favor as well as against 
      them.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Chkhotua, A
AU  - Chkhotua A
AD  - National Centre of Urology, Tbilisi, Georgia. achkhotua@gmail.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - Altruism
MH  - *Financial Support/ethics
MH  - *Gift Giving/ethics
MH  - Government Regulation
MH  - Health Care Costs/ethics
MH  - Health Expenditures/ethics
MH  - Health Policy
MH  - Humans
MH  - *Motivation/ethics
MH  - Tissue Donors/ethics/legislation & jurisprudence/*psychology/*supply &
      distribution
MH  - *Tissue and Organ Procurement/economics/ethics/legislation & jurisprudence
EDAT- 2012/07/31 06:00
MHDA- 2013/01/04 06:00
CRDT- 2012/07/31 06:00
PHST- 2012/07/31 06:00 [entrez]
PHST- 2012/07/31 06:00 [pubmed]
PHST- 2013/01/04 06:00 [medline]
AID - S0041-1345(12)00503-9 [pii]
AID - 10.1016/j.transproceed.2012.05.038 [doi]
PST - ppublish
SO  - Transplant Proc. 2012 Jul-Aug;44(6):1793-4. doi:
      10.1016/j.transproceed.2012.05.038.


PMID- 22841273
OWN - NLM
STAT- MEDLINE
DCOM- 20130103
LR  - 20220409
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 44
IP  - 6
DP  - 2012 Jul-Aug
TI  - Living donor nephrectomy--quantifying the risk for the donor.
PG  - 1786-9
LID - 10.1016/j.transproceed.2012.06.006 [doi]
AB  - Living kidney donation is on the rise, either due to cultural or ethical reasons 
      or due to a lack of deceased donor kidneys. For adequately counseling of a
      potential living kidney donor, medical professionals must know not only the
      immediate risks of kidney donation but also possible long-term effects of kidney 
      donation on the donor's physical and psychological well-being. This also includes
      a range of aspects such as quality of life, insurance issues, and family planning
      following kidney donation. This review article is based on a Medline and PubMed
      search and elucidates the risks living kidney donors face with regard to all
      aspects just mentioned. Living kidney donation does not end with the operative
      procedure--long-term cost-free physical and psychological follow-up should be
      offered to each donor for the gift he or she is willing to give to the recipient.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Giessing, M
AU  - Giessing M
AD  - Department of Urology, Heinrich Heine University Hospital, Duesseldorf, Germany. 
      markus.giessing@med.uni-duesseldorf.de
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - Humans
MH  - Kidney Transplantation/*adverse effects/methods/mortality/psychology
MH  - *Living Donors/psychology
MH  - Nephrectomy/*adverse effects/mortality/psychology
MH  - Postoperative Complications/etiology/mortality
MH  - Quality of Life
MH  - Risk Assessment
MH  - Risk Factors
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2012/07/31 06:00
MHDA- 2013/01/04 06:00
CRDT- 2012/07/31 06:00
PHST- 2012/07/31 06:00 [entrez]
PHST- 2012/07/31 06:00 [pubmed]
PHST- 2013/01/04 06:00 [medline]
AID - S0041-1345(12)00549-0 [pii]
AID - 10.1016/j.transproceed.2012.06.006 [doi]
PST - ppublish
SO  - Transplant Proc. 2012 Jul-Aug;44(6):1786-9. doi:
      10.1016/j.transproceed.2012.06.006.


PMID- 22841233
OWN - NLM
STAT- MEDLINE
DCOM- 20130103
LR  - 20181201
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 44
IP  - 6
DP  - 2012 Jul-Aug
TI  - Effects of desflurane and isoflurane on hepatic and renal functions and
      coagulation profile during donor hepatectomy.
PG  - 1635-9
LID - 10.1016/j.transproceed.2012.05.047 [doi]
AB  - We compared the effect of two inhalation anesthetics desflurane and isoflurane on
      postoperative hepatic and renal functions as well as coagulation profiles in
      living donors undergoing right hepatectomy. This study was performed on 80
      patients who were randomly allocated to group D (desflurane, n = 40) or group I
      (isoflurane, n = 40) after Faculty Ethics Committee approval. After induction,
      isoflurane or desflurane was used with air/oxygen for anesthetic maintenance. The
      isoflurane or desflurane concentration was set at one minimum alveolar
      concentration (MAC). Remifentanil was infused for analgesia as well as
      cisatracurium. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), 
      international normalized ratio (INR), albumin, total bilirubin, blood urea
      nitrogen, creatinine, platelet count, and hemoglobin levels were analyzed
      preoperatively at end of the operation, and on postoperative days (PODs) 1, 2, 3,
      5, 7, and 30. Both AST and ALT differed significantly and continually except on
      POD 30. AST showed significant elevations from the end of the operation to POD 2 
      and ALT, from the end of the operation to POD 5 in group I compared with group D.
      INR was significantly higher from the end of the operation to POD 3 in group I
      and to POD 2 in group D. At the end of the operation as well as on POD 1 and POD 
      2, INR was significantly increased in group I compared with group D. Albumin
      level was significantly lower at the end of the operation in both groups, but it 
      was not different. No patient developed hepatic or renal failure. Our study
      showed better postoperative hepatic tests and INR using desflurane than
      isoflurane at equivalent doses of 1 MAC in living donors undergoing right
      hepatectomy.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Toprak, H I
AU  - Toprak HI
AD  - Department of Anesthesiology, Medical School of Inonu University, Malatya,
      Turkey. huseyin.toprak@inonu.edu.tr
FAU - Sahin, T
AU  - Sahin T
FAU - Aslan, S
AU  - Aslan S
FAU - Karahan, K
AU  - Karahan K
FAU - Sanli, M
AU  - Sanli M
FAU - Ersoy, M O
AU  - Ersoy MO
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - 0 (Anesthetics, Inhalation)
RN  - 0 (Biomarkers)
RN  - CRS35BZ94Q (Desflurane)
RN  - CYS9AKD70P (Isoflurane)
SB  - IM
MH  - Adult
MH  - Anesthetics, Inhalation/*administration & dosage/adverse effects
MH  - Biomarkers/blood
MH  - Blood Coagulation/*drug effects
MH  - Desflurane
MH  - Female
MH  - *Hepatectomy/adverse effects
MH  - Humans
MH  - International Normalized Ratio
MH  - Isoflurane/administration & dosage/adverse effects/*analogs & derivatives
MH  - Kidney/*drug effects/physiopathology
MH  - Kidney Function Tests
MH  - Liver/*drug effects/physiopathology/*surgery
MH  - Liver Function Tests
MH  - *Liver Transplantation/adverse effects
MH  - *Living Donors
MH  - Male
MH  - Middle Aged
MH  - Postoperative Complications/blood/etiology/physiopathology/*prevention & control
MH  - Predictive Value of Tests
MH  - Time Factors
MH  - Treatment Outcome
MH  - Turkey
MH  - Young Adult
EDAT- 2012/07/31 06:00
MHDA- 2013/01/04 06:00
CRDT- 2012/07/31 06:00
PHST- 2012/07/31 06:00 [entrez]
PHST- 2012/07/31 06:00 [pubmed]
PHST- 2013/01/04 06:00 [medline]
AID - S0041-1345(12)00512-X [pii]
AID - 10.1016/j.transproceed.2012.05.047 [doi]
PST - ppublish
SO  - Transplant Proc. 2012 Jul-Aug;44(6):1635-9. doi:
      10.1016/j.transproceed.2012.05.047.


PMID- 22841201
OWN - NLM
STAT- MEDLINE
DCOM- 20130103
LR  - 20191210
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 44
IP  - 6
DP  - 2012 Jul-Aug
TI  - Statistical quality control charts for liver transplant process indicators:
      evaluation of a single-center experience.
PG  - 1517-22
LID - 10.1016/j.transproceed.2012.05.009 [doi]
AB  - Liver transplantation, the best option for many end-stage liver diseases, is
      indicated in more candidates than the donor availability. In this situation, this
      demanding treatment must achieve excellence, accessibility and patient
      satisfaction to be ethical, scientific, and efficient. The current consensus of
      quality measurements promoted by the Sociedad Espanola de Trasplante Hepatico
      (SETH) seeks to depict criteria, indicators, and standards for liver
      transplantation in Spain. According to this recommendation, the Canary Islands
      liver program has studied its experience. We separated the 411 cadaveric
      transplants performed in the last 15 years into 2 groups: The first 100 and the
      other 311. The 8 criteria of SETH 2010 were correctly fulfilled. In most
      indicators, the outcomes were favorable, with an actuarial survivals at 1, 3, 5, 
      and 10 years of 84%, 79%, 76%, and 65%, respectively; excellent results in
      retransplant rates (early 0.56% and long-term 5.9%), primary nonfunction rate
      (0.43%), waiting list mortality (13.34%), and patient satisfaction (91.5%). On
      the other hand, some indicators of mortality were worse as perioperative,
      postoperative, and early mortality with normal graft function and reoperation
      rate. After the analyses of the series with statistical quality control charts,
      we observed an improvement in all indicators, even in the apparently worst, early
      mortality with normal graft functions in a stable program. Such results helped us
      to discover specific areas to improve the program. The application of the quality
      measurement, as SETH consensus recommends, has shown in our study that despite
      being a consuming time process, it is a useful tool.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Varona, M A
AU  - Varona MA
AD  - Department of Surgery, Hospital Universitario Nuestra Senora de Candelaria, Santa
      Cruz de Tenerife, Spain. mvarbosa@gmail.com
FAU - Soriano, A
AU  - Soriano A
FAU - Aguirre-Jaime, A
AU  - Aguirre-Jaime A
FAU - Barrera, M A
AU  - Barrera MA
FAU - Medina, M L
AU  - Medina ML
FAU - Banon, N
AU  - Banon N
FAU - Mendez, S
AU  - Mendez S
FAU - Lopez, E
AU  - Lopez E
FAU - Portero, J
AU  - Portero J
FAU - Dominguez, D
AU  - Dominguez D
FAU - Gonzalez, A
AU  - Gonzalez A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
SB  - IM
MH  - Graft Survival
MH  - Guideline Adherence
MH  - Humans
MH  - Liver Transplantation/adverse effects/mortality/standards/*statistics & numerical
      data
MH  - Outcome and Process Assessment, Health Care/standards/*statistics & numerical
      data
MH  - Patient Satisfaction
MH  - Postoperative Complications/etiology/surgery
MH  - Practice Guidelines as Topic
MH  - Program Evaluation
MH  - Quality Improvement/standards/*statistics & numerical data
MH  - Quality Indicators, Health Care/standards/*statistics & numerical data
MH  - Reoperation
MH  - Retrospective Studies
MH  - Spain
MH  - Time Factors
MH  - Treatment Outcome
MH  - Waiting Lists
EDAT- 2012/07/31 06:00
MHDA- 2013/01/04 06:00
CRDT- 2012/07/31 06:00
PHST- 2012/07/31 06:00 [entrez]
PHST- 2012/07/31 06:00 [pubmed]
PHST- 2013/01/04 06:00 [medline]
AID - S0041-1345(12)00440-X [pii]
AID - 10.1016/j.transproceed.2012.05.009 [doi]
PST - ppublish
SO  - Transplant Proc. 2012 Jul-Aug;44(6):1517-22. doi:
      10.1016/j.transproceed.2012.05.009.


PMID- 22840240
OWN - NLM
STAT- MEDLINE
DCOM- 20121210
LR  - 20211021
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 98
IP  - 4
DP  - 2012 Oct
TI  - Recruiting egg donors online: an analysis of in vitro fertilization clinic and
      agency websites' adherence to American Society for Reproductive Medicine
      guidelines.
PG  - 995-1000
LID - 10.1016/j.fertnstert.2012.06.052 [doi]
LID - S0015-0282(12)00705-4 [pii]
AB  - OBJECTIVE: To examine compliance with ethical guidelines of the American Society 
      for Reproductive Medicine (ASRM) regarding trait-based payment variation,
      presentation of risks, and minimum recruitment age. DESIGN: In June 2010, we
      systematically examined 207 websites, of which 102 were egg donor agency or IVF
      clinic websites that both recruited online and displayed compensation amounts.
      SETTING: The Internet. PATIENT(S): None. INTERVENTION(S): Not applicable. MAIN
      OUTCOME MEASURE(S): Mention of increased payment for particular donor traits,
      recruitment age less than 21 years, noting risks to donors. RESULT(S): Of the 102
      sites, considerable numbers were noncompliant with ASRM's guidelines that
      prohibit varying compensation based on a donor's traits (34%), and recommend an
      age of 21 years or older (41%), and presentation of risks alongside compensation 
      (56%). Trait-based payment variation was associated with being an agency rather
      than a clinic, location in the West, not being endorsed by ASRM or Society of
      Assisted Reproductive Technology (SART), and referring to ASRM's guidelines about
      compensation. Of sites mentioning traits, prior donation success was the most
      commonly paid for trait (64%). CONCLUSION(S): Our data, the first to
      systematically analyze agency and clinic websites reveal that many do not follow 
      ASRM's guidelines. These data have critical implications for policy, practice,
      and research, suggesting needs for consideration of possible changes in
      guidelines, and/or improvements in compliance and monitoring by ASRM or others.
CI  - Copyright (c) 2012 American Society for Reproductive Medicine. Published by
      Elsevier Inc. All rights reserved.
FAU - Keehn, Jason
AU  - Keehn J
AD  - Masters Program in Bioethics, Columbia University, New York, New York 10032, USA.
FAU - Holwell, Eve
AU  - Holwell E
FAU - Abdul-Karim, Ruqayyah
AU  - Abdul-Karim R
FAU - Chin, Lisa Judy
AU  - Chin LJ
FAU - Leu, Cheng-Shiun
AU  - Leu CS
FAU - Sauer, Mark V
AU  - Sauer MV
FAU - Klitzman, Robert
AU  - Klitzman R
LA  - eng
GR  - P20 HG005535/HG/NHGRI NIH HHS/United States
GR  - R01 HG002431/HG/NHGRI NIH HHS/United States
PT  - Journal Article
DEP - 20120727
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
SB  - IM
MH  - Advertising/ethics/*standards
MH  - Female
MH  - Fertilization in Vitro/economics/ethics/*standards
MH  - Guideline Adherence/*standards
MH  - Humans
MH  - Internet/ethics/*standards
MH  - Oocyte Donation/economics/ethics/*standards
MH  - Practice Guidelines as Topic
MH  - Societies, Medical/standards
MH  - United States
PMC - PMC3470907
MID - NIHMS397278
EDAT- 2012/07/31 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/07/31 06:00
PHST- 2011/12/13 00:00 [received]
PHST- 2012/05/25 00:00 [revised]
PHST- 2012/06/27 00:00 [accepted]
PHST- 2012/07/31 06:00 [entrez]
PHST- 2012/07/31 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - S0015-0282(12)00705-4 [pii]
AID - 10.1016/j.fertnstert.2012.06.052 [doi]
PST - ppublish
SO  - Fertil Steril. 2012 Oct;98(4):995-1000. doi: 10.1016/j.fertnstert.2012.06.052.
      Epub 2012 Jul 27.


PMID- 22838299
OWN - NLM
STAT- MEDLINE
DCOM- 20120910
LR  - 20120730
IS  - 0025-7818 (Print)
IS  - 0025-7818 (Linking)
VI  - 103
IP  - 3
DP  - 2012 May-Jun
TI  - Health protection of health care workers from the prospective of ethics, science 
      and good medical practice. Opinions from stakeholders in health care settings.
PG  - 212-9
AB  - Fitness for work (FFW) in health care workers poses multidisciplinary challenges 
      because of management problems scientific and ethical implications and the
      implementation of preventive interventions in health care settings. All the
      relevant stakeholders, including the General Manager, Medical Director, worker's 
      representative, the person responsible for prevention and protection, forensic
      medicine expert, the person responsible for prevention and health safety at
      public administration level, commented on: danger to third parties; FFW
      formulation; human resource management; stress; professional independence; role
      of the person responsible for prevention and protection and of the person
      responsible for prevention at public administration level; professional
      responsibilities. Opinions are reported regarding the main problems related to
      the role of the Occupational Physician in FFW formulation, such as the difficult 
      balance between autonomy and independence, limited turnover and aging of
      workforce, need of confidentiality and respect for professional status of the HCW
      prevalence of susceptibility conditions, rights and duties of stakeholders. The
      most significant result was the request by the Lombardy Region for more quality
      in risk assessment and health surveillance; to maintain uniform conduct over all 
      the local health authorities, to allow the board in charge of examining appeals
      against FFW to fully cooperate with the occupational physician; due attention to 
      the person/worker; the opportunity to convene referral boards for complex FFW
      management; the challenge of stress management and the need for an observatory
      for psychological discomforts; the importance of the ICOH Code of Ethics and
      avoidance of conflicts of interests; the need for individual risk assessment and 
      risk management; the concept of sharing responsibilities and of a real
      multidisciplinary approach.
FAU - Porru, S
AU  - Porru S
AD  - Sezione di Medicina del Lavoro e Igiene Industriale, Universita di Bresci.
      porru@med.unibs.it
FAU - Cannatelli, P
AU  - Cannatelli P
FAU - Cerioli, Beloyanna
AU  - Cerioli B
FAU - Flor, L
AU  - Flor L
FAU - Gramegna, Maria
AU  - Gramegna M
FAU - Polato, R
AU  - Polato R
FAU - Rodriguez, D
AU  - Rodriguez D
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Med Lav
JT  - La Medicina del lavoro
JID - 0401176
SB  - IM
MH  - Attitude of Health Personnel
MH  - *Delivery of Health Care
MH  - *Health Personnel
MH  - Humans
MH  - *Occupational Health
MH  - *Occupational Medicine/ethics/standards
MH  - *Work Capacity Evaluation
EDAT- 2012/07/31 06:00
MHDA- 2012/09/11 06:00
CRDT- 2012/07/31 06:00
PHST- 2012/07/31 06:00 [entrez]
PHST- 2012/07/31 06:00 [pubmed]
PHST- 2012/09/11 06:00 [medline]
PST - ppublish
SO  - Med Lav. 2012 May-Jun;103(3):212-9.


PMID- 22838295
OWN - NLM
STAT- MEDLINE
DCOM- 20120910
LR  - 20131121
IS  - 0025-7818 (Print)
IS  - 0025-7818 (Linking)
VI  - 103
IP  - 3
DP  - 2012 May-Jun
TI  - Fitness for work in health care workers: biological risk.
PG  - 175-86
AB  - The aim of this contribution is to propose good medical practice in formulating
      and managing fitness for work (FFW) for health care workers exposed to biological
      agents. A literature review was conducted, together with a critical analysis of
      available scientific evidence and presentation of practical examples taken from
      the Italian multicentric study in which the authors have been participating since
      2008. Within the health care sector and with special reference to biological
      risk, making and subsequently managing a FFW for a specific job is in fact a
      particularly arduous task for the occupational physician and for the entire
      hospital management system. The process that leads to issuing a FFW needs to
      follow the appropriate guidelines and good technical and scientific practice and 
      also take into careful consideration current legislation (national, regional,
      etc); it is the result of a well grounded balance between professional ethics,
      rights and duties of the worker and patient, but also of the employer and of all 
      those involved. All these aspects need to be adapted to the single work
      situations, applying the principle of precaution and careful flexibility in
      management, with accurate evaluation of each individual clinical case with its
      peculiarities and referral, where necessary, to expert opinion. It is also
      indispensable to have in place a clear and jointly agreed hospital management
      policy where co-responsibility is taken by each single actor, always with due
      respect for specific roles, so that the Occupational Physician and employers are 
      not left to manage the issue alone.
FAU - Porru, S
AU  - Porru S
AD  - Dipartimento di Medicina Sperimentale ed Applicata, Sezione di Medicina del
      Lavoro, Universita degli Studi di Brescia. porru@med.unibs.it
FAU - Micheloni, G P
AU  - Micheloni GP
FAU - Carrer, P
AU  - Carrer P
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - Med Lav
JT  - La Medicina del lavoro
JID - 0401176
RN  - 0 (Biological Products)
SB  - IM
MH  - Biological Products
MH  - Europe
MH  - *Health Personnel
MH  - Humans
MH  - Italy
MH  - *Occupational Exposure
MH  - *Occupational Health
MH  - Practice Guidelines as Topic
MH  - *Work Capacity Evaluation
EDAT- 2012/07/31 06:00
MHDA- 2012/09/11 06:00
CRDT- 2012/07/31 06:00
PHST- 2012/07/31 06:00 [entrez]
PHST- 2012/07/31 06:00 [pubmed]
PHST- 2012/09/11 06:00 [medline]
PST - ppublish
SO  - Med Lav. 2012 May-Jun;103(3):175-86.


PMID- 22838294
OWN - NLM
STAT- MEDLINE
DCOM- 20120910
LR  - 20120730
IS  - 0025-7818 (Print)
IS  - 0025-7818 (Linking)
VI  - 103
IP  - 3
DP  - 2012 May-Jun
TI  - Fitness for work in health care workers from the prospective of ethics, science
      and good practices.
PG  - 165-74
AB  - Fitness for work (FFW) is the final task of both risk assessment and health
      surveillance, aimed at protecting workers' health and working capacity. There are
      numerous specific concerns regarding health care workers. In particular: i) the
      frequent difficulty in determining at pre-employment/pre-placement examinations
      the specific task that the individual worker will perform; ii) the prevalence of 
      female workers and the contemporary presence of numerous occupational risk
      factors that are a potential cause of harmful effects on women's reproductive
      health; iii) the progressive aging of the staff especially nurses; iv) the risk
      to third parties, with particular reference to the issues of biological risk and 
      substance abuse, also in relation to shift work, fatigue and occupational stress;
      v) the increasing number of immigrant workers among support staff In such cases
      the occupational physician, respecting both ethical principles and regulations
      and with an appropriate balance between scientific evidence and the precautionary
      principle, should express a FFW judgment that allows both the adaptation of work 
      to the worker and vice versa, as recommended by the World Health Organization
      (WHO) and the International Commission on Occupational Health (ICOH). Proper FFW 
      judgment also permits the expected benefits to be achieved, not only for the
      workers but also for employers, companies and society.
FAU - Alessio, L
AU  - Alessio L
AD  - Department of Experimental and Applied Medicine, Section of Occupational Health
      and Industrial Hygiene, University of Brescia, Italy.
FAU - Arici, Cecilia
AU  - Arici C
FAU - Franco, G
AU  - Franco G
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Med Lav
JT  - La Medicina del lavoro
JID - 0401176
SB  - IM
MH  - Age Factors
MH  - Female
MH  - *Health Personnel
MH  - Humans
MH  - Italy
MH  - Male
MH  - *Occupational Health/ethics/standards
MH  - Quality of Health Care
MH  - Risk Assessment
MH  - *Work Capacity Evaluation
EDAT- 2012/07/31 06:00
MHDA- 2012/09/11 06:00
CRDT- 2012/07/31 06:00
PHST- 2012/07/31 06:00 [entrez]
PHST- 2012/07/31 06:00 [pubmed]
PHST- 2012/09/11 06:00 [medline]
PST - ppublish
SO  - Med Lav. 2012 May-Jun;103(3):165-74.


PMID- 22838276
OWN - NLM
STAT- MEDLINE
DCOM- 20120911
LR  - 20120730
IS  - 0035-2640 (Print)
IS  - 0035-2640 (Linking)
VI  - 62
IP  - 6
DP  - 2012 Jun
TI  - [Determination of the total work incapacity].
PG  - 798-800
AB  - At the request of the patient or required by a requisition, the physician may be 
      asked to deliver medical certificates with determination of total work incapacity
      (TWI). This is an attestation of what he has observed and incurs his penal, civil
      and ethical responsability. The drafting of such certificates implies not only
      the doctor and the patient, but also the judicial authorities and the alleged
      offender or offenders. The impact of the determination of the TWI is important to
      know in order to write "good" certificates before justifying TWI.
FAU - Ferrant, Ophelie
AU  - Ferrant O
AD  - Universite Paris-Descartes, urgences medico-judiciaires, Hotel-Dieu, AP-HP, 75004
      Paris. ophelie.ferrant@yahoo.fr
FAU - Barthes, Agnes
AU  - Barthes A
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Determination de l'ITT.
PL  - France
TA  - Rev Prat
JT  - La Revue du praticien
JID - 0404334
SB  - IM
MH  - Crime Victims/rehabilitation
MH  - Humans
MH  - Medical Records/legislation & jurisprudence/standards
MH  - Physician's Role
MH  - Practice Guidelines as Topic
MH  - Sick Leave/legislation & jurisprudence
MH  - Violence/ethics/legislation & jurisprudence
MH  - *Work Capacity Evaluation
MH  - Wounds and Injuries/*diagnosis/therapy
MH  - Writing
EDAT- 2012/07/31 06:00
MHDA- 2012/09/12 06:00
CRDT- 2012/07/31 06:00
PHST- 2012/07/31 06:00 [entrez]
PHST- 2012/07/31 06:00 [pubmed]
PHST- 2012/09/12 06:00 [medline]
PST - ppublish
SO  - Rev Prat. 2012 Jun;62(6):798-800.


PMID- 22838254
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20120730
IS  - 0024-7758 (Print)
IS  - 0024-7758 (Linking)
VI  - 57
IP  - 7-8
DP  - 2012 Jul-Aug
TI  - Role of hysterectomy in the management of patients with gestational trophoblastic
      neoplasia: importance of receiving treatment in reference centers.
PG  - 359-68
AB  - OBJECTIVE: To evaluate hysterectomy prevalence, indications and impact on
      clinical outcomes in a reference center in southern Brazil. STUDY DESIGN:
      Institutional Ethical Committee approval was granted for this study. In a cohort 
      study spanning 21 years, all patients who underwent hysterectomy for gestational 
      trophoblastic neoplasia (GTN) were included, and technical differences between
      hysterectomy performed in the reference center and those performed elsewhere were
      evaluated as well. RESULTS: Of 1,023 patients with gestational trophoblastic
      disease, 57 (5.6%) underwent hysterectomy (95% CI, 4.3-7.1). Hysterectomy
      incidence in 230 GTN patients was 17.7% (95%CI, 15.1-23.3). Indications for 41
      hysterectomies in the reference center were as follows: primary treatment in 14
      (34.1%) cases and secondary treatment in 27 (65.9%); of these, the main
      indications were GTN recurrence (7 [25.9%] cases), hemorrhage (6 [22.2%]),
      resistance to single-agent chemotherapy in patients who refused more aggressive
      treatment (6 [22.2%]), and tumor mass reduction (5 [18.5%]). Twelve (92.3%) of
      the 13 hysterectomies with bilateral oophorectomy were performed elsewhere (p <
      0.001). Thirty-five (85.4%) patients had no complications, and median
      hospitalization time was short (3 +/- 4 days). None of the 4 deaths were
      associated with hysterectomy. In the reference center, when associated with
      hysterectomy, GTN cure rates reached 93% after 63 +/- 87 months of follow-up.
      CONCLUSION: When treatment is in a reference center, hysterectomy frequency and
      morbidity may be low, and indications due to hemorrhage are significantly lower. 
      Furthermore, at a reference center there is significantly greater ovarian
      preservation at the time of hysterectomy, and significantly more patients who
      undergo hysterectomy have low-risk GTN.
FAU - Pires, Leticia Vicosa
AU  - Pires LV
AD  - Graduate Program in Pathology, School of Medicine, Universidade Federal de
      Ciencias da Saude de Porto Alegre, Porto Alegre, RS, Brazil.
      leticia.pires@terra.com.br
FAU - Uberti, Elza M Hartmann
AU  - Uberti EM
FAU - Fajardo, Maria do Carmo
AU  - Fajardo Mdo C
FAU - da Cunha, Adriana G Vieira
AU  - da Cunha AG
FAU - Rosa, Marcos Wengrover
AU  - Rosa MW
FAU - Ayub, Antonio Celso K
AU  - Ayub AC
FAU - El Beitume, Patricia
AU  - El Beitume P
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Reprod Med
JT  - The Journal of reproductive medicine
JID - 0173343
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antineoplastic Agents/therapeutic use
MH  - Brazil
MH  - Cohort Studies
MH  - Drug Resistance, Neoplasm
MH  - Female
MH  - Gestational Trophoblastic Disease/drug therapy/mortality/*surgery
MH  - Humans
MH  - *Hysterectomy
MH  - Length of Stay
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local
MH  - Ovariectomy
MH  - Pregnancy
MH  - Uterine Neoplasms/drug therapy/mortality/*surgery
EDAT- 2012/07/31 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/07/31 06:00
PHST- 2012/07/31 06:00 [entrez]
PHST- 2012/07/31 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
PST - ppublish
SO  - J Reprod Med. 2012 Jul-Aug;57(7-8):359-68.


PMID- 22837612
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130704
LR  - 20220318
IS  - 1998-3735 (Electronic)
IS  - 0973-1075 (Linking)
VI  - 18
IP  - 1
DP  - 2012 Jan
TI  - Should Patients and Family be Involved in "Do Not Resuscitate" Decisions? Views
      of Oncology and Palliative Care Doctors and Nurses.
PG  - 52-8
LID - 10.4103/0973-1075.97474 [doi]
AB  - BACKGROUND: "Do not resuscitate" (DNR) orders are put in place where
      cardiopulmonary resuscitation is inappropriate. However, it is unclear who should
      be involved in discussions and decisions around DNR orders. AIM: The aim was to
      determine the views of oncology and palliative care doctors and nurses on DNR
      orders. MATERIALS AND METHODS: A questionnaire survey was conducted on 146
      doctors and nurses in oncology and palliative care working within a tertiary
      specialist cancer center in Singapore. RESULTS: Perceived care differences as a
      result of DNR determinations led to 50.7% of respondents reporting concerns that 
      a DNR order would mean that the patient received a substandard level of care. On 
      the matter of DNR discussions, majority thought that patients (78.8%) and the
      next of kin (78.1%) should be involved though with whom the ultimate decision lay
      differed. There was also a wide range of views on the most appropriate time to
      have a DNR discussion. CONCLUSIONS: From the viewpoint of oncology and palliative
      care healthcare professionals, patients should be involved at least in discussing
      if not in the determination of DNR orders, challenging the norm of familial
      determination in the Asian context. The varied responses highlight the complexity
      of decision making on issues relating to the end of life. Thus, it is important
      to take into account the innumerable bio-psychosocial, practical, and ethical
      factors that are involved within such deliberations.
FAU - Yang, Grace M
AU  - Yang GM
AD  - Department of Palliative Medicine, National Cancer Centre Singapore, Singapore.
FAU - Kwee, Ann K
AU  - Kwee AK
FAU - Krishna, Lalit
AU  - Krishna L
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Indian J Palliat Care
JT  - Indian journal of palliative care
JID - 101261221
PMC - PMC3401735
OTO - NOTNLM
OT  - Asian Continental Ancestry Group
OT  - Decision making
OT  - Medical oncology
OT  - Palliative care
OT  - Resuscitation orders
EDAT- 2012/07/28 06:00
MHDA- 2012/07/28 06:01
CRDT- 2012/07/28 06:00
PHST- 2012/07/28 06:00 [entrez]
PHST- 2012/07/28 06:00 [pubmed]
PHST- 2012/07/28 06:01 [medline]
AID - 10.4103/0973-1075.97474 [doi]
AID - IJPC-18-52 [pii]
PST - ppublish
SO  - Indian J Palliat Care. 2012 Jan;18(1):52-8. doi: 10.4103/0973-1075.97474.


PMID- 22837556
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120814
LR  - 20220408
IS  - 1998-3611 (Electronic)
IS  - 0019-5154 (Linking)
VI  - 57
IP  - 4
DP  - 2012 Jul
TI  - Rational and ethical use of topical corticosteroids based on safety and efficacy.
PG  - 251-9
LID - 10.4103/0019-5154.97655 [doi]
AB  - Topical corticosteroids (TC) have greatly contributed to the dermatologist's
      ability to effectively treat several difficult dermatoses. The available range of
      formulations and potency gives flexibility to treat all groups of patients,
      different phases of disease, and different anatomic sites. However, the rapid
      rise in incidence of improper use of these drugs by dermatologists, general
      physicians, and patients threatens to bring disrepute to the entire group of
      these amazing drugs. Responsibility to disseminate proper knowledge regarding
      when, where, and how to use TC both to internists and patients rests primarily
      with the dermatologist. Benefits of rational and ethical use and the harm of
      overuse and misuse for nonmedical, specially for cosmetic purposes, should be
      clearly conveyed before penning a prescription involving TC. Simultaneous efforts
      to use political, legal, and other institutions to prevent misuse of these drugs 
      by rationing their availability only through proper prescriptions will greatly
      help the cause. This will hopefully bring down both the extremes of ever
      increasing cases of steroid-induced dermatoses on one hand and the irrational
      fears of using TC in well justified indications on the other.
FAU - Rathi, Sanjay K
AU  - Rathi SK
AD  - Consultant Dermatologist, Siliguri, West Bengal, India. drsrathi2@gmail.com
FAU - D'Souza, Paschal
AU  - D'Souza P
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Dermatol
JT  - Indian journal of dermatology
JID - 0370750
PMC - PMC3401837
OTO - NOTNLM
OT  - Abuse
OT  - adverse effects
OT  - ethical use
OT  - indications
OT  - misuse
OT  - rational use
OT  - steroid responsive dermatoses
OT  - topical corticosteroids
EDAT- 2012/07/28 06:00
MHDA- 2012/07/28 06:01
CRDT- 2012/07/28 06:00
PHST- 2012/07/28 06:00 [entrez]
PHST- 2012/07/28 06:00 [pubmed]
PHST- 2012/07/28 06:01 [medline]
AID - 10.4103/0019-5154.97655 [doi]
AID - IJD-57-251 [pii]
PST - ppublish
SO  - Indian J Dermatol. 2012 Jul;57(4):251-9. doi: 10.4103/0019-5154.97655.


PMID- 22837010
OWN - NLM
STAT- MEDLINE
DCOM- 20121231
LR  - 20220318
IS  - 1521-0103 (Electronic)
IS  - 0022-3565 (Linking)
VI  - 343
IP  - 2
DP  - 2012 Nov
TI  - Identification of granulocyte colony-stimulating factor and interleukin-6 as
      candidate biomarkers of CBLB502 efficacy as a medical radiation countermeasure.
PG  - 497-508
LID - 10.1124/jpet.112.196071 [doi]
AB  - Given an ever-increasing risk of nuclear and radiological emergencies, there is a
      critical need for development of medical radiation countermeasures (MRCs) that
      are safe, easily administered, and effective in preventing and/or mitigating the 
      potentially lethal tissue damage caused by acute high-dose radiation exposure.
      Because the efficacy of MRCs for this indication cannot be ethically tested in
      humans, development of such drugs is guided by the Food and Drug Administration's
      Animal Efficacy Rule. According to this rule, human efficacious doses can be
      projected from experimentally established animal efficacious doses based on the
      equivalence of the drug's effects on efficacy biomarkers in the respective
      species. Therefore, identification of efficacy biomarkers is critically important
      for drug development under the Animal Efficacy Rule. CBLB502 is a truncated
      derivative of the Salmonella flagellin protein that acts by triggering Toll-like 
      receptor 5 (TLR5) signaling and is currently under development as a MRC. Here, we
      report identification of two cytokines, granulocyte colony-stimulating factor
      (G-CSF) and interleukin-6 (IL-6), as candidate biomarkers of CBLB502's
      radioprotective/mitigative efficacy. Induction of both G-CSF and IL-6 by CBLB502 
      1) is strictly TLR5-dependent, 2) occurs in a CBLB502 dose-dependent manner
      within its efficacious dose range in both nonirradiated and irradiated mammals,
      including nonhuman primates, and 3) is critically important for the ability of
      CBLB502 to rescue irradiated animals from death. After evaluation of CBLB502
      effects on G-CSF and IL-6 levels in humans, these biomarkers will be useful for
      accurate prediction of human efficacious CBLB502 doses, a key step in the
      development of this prospective radiation countermeasure.
FAU - Krivokrysenko, Vadim I
AU  - Krivokrysenko VI
AD  - Cleveland BioLabs, Inc., 73 High Street, Buffalo, NY 14203, USA.
FAU - Shakhov, Alexander N
AU  - Shakhov AN
FAU - Singh, Vijay K
AU  - Singh VK
FAU - Bone, Frederick
AU  - Bone F
FAU - Kononov, Yevgeniy
AU  - Kononov Y
FAU - Shyshynova, Inna
AU  - Shyshynova I
FAU - Cheney, Alec
AU  - Cheney A
FAU - Maitra, Ratan K
AU  - Maitra RK
FAU - Purmal, Andrei
AU  - Purmal A
FAU - Whitnall, Mark H
AU  - Whitnall MH
FAU - Gudkov, Andrei V
AU  - Gudkov AV
FAU - Feinstein, Elena
AU  - Feinstein E
LA  - eng
GR  - R01AI080446/AI/NIAID NIH HHS/United States
GR  - RC2AI087616/AI/NIAID NIH HHS/United States
GR  - C0000008/CL/CLC NIH HHS/United States
GR  - RC2 AI087616/AI/NIAID NIH HHS/United States
GR  - R01 AI080446/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20120726
PL  - United States
TA  - J Pharmacol Exp Ther
JT  - The Journal of pharmacology and experimental therapeutics
JID - 0376362
RN  - 0 (Biomarkers)
RN  - 0 (CBLB502)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-6)
RN  - 0 (Peptides)
RN  - 143011-72-7 (Granulocyte Colony-Stimulating Factor)
SB  - IM
MH  - Animals
MH  - Area Under Curve
MH  - Biomarkers/*metabolism
MH  - Cytokines/analysis/metabolism
MH  - Dogs
MH  - Dose-Response Relationship, Drug
MH  - Dose-Response Relationship, Radiation
MH  - Female
MH  - Granulocyte Colony-Stimulating Factor/genetics/*metabolism
MH  - Humans
MH  - Injections, Intramuscular
MH  - Interleukin-6/genetics/*metabolism
MH  - Kaplan-Meier Estimate
MH  - Macaca mulatta
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred ICR
MH  - Peptides/administration & dosage/*pharmacology
MH  - Species Specificity
MH  - Whole-Body Irradiation/adverse effects
PMC - PMC3477210
EDAT- 2012/07/28 06:00
MHDA- 2013/01/01 06:00
CRDT- 2012/07/28 06:00
PHST- 2012/07/28 06:00 [entrez]
PHST- 2012/07/28 06:00 [pubmed]
PHST- 2013/01/01 06:00 [medline]
AID - jpet.112.196071 [pii]
AID - 10.1124/jpet.112.196071 [doi]
PST - ppublish
SO  - J Pharmacol Exp Ther. 2012 Nov;343(2):497-508. doi: 10.1124/jpet.112.196071. Epub
      2012 Jul 26.


PMID- 22836987
OWN - NLM
STAT- MEDLINE
DCOM- 20120827
LR  - 20211021
IS  - 1476-4687 (Electronic)
IS  - 0028-0836 (Linking)
VI  - 487
IP  - 7408
DP  - 2012 Jul 25
TI  - Research accountability: Mandate ethics methods in papers.
PG  - 432
LID - 10.1038/487432a [doi]
FAU - Anderson, James A
AU  - Anderson JA
FAU - Eijkholt, Marleen
AU  - Eijkholt M
FAU - Illes, Judy
AU  - Illes J
LA  - eng
PT  - Letter
DEP - 20120725
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
SB  - IM
MH  - Biomedical Research/*ethics/methods/*standards
MH  - *Ethics, Research
MH  - Guidelines as Topic
MH  - Publishing/*standards/trends
MH  - Reproducibility of Results
EDAT- 2012/07/28 06:00
MHDA- 2012/08/28 06:00
CRDT- 2012/07/28 06:00
PHST- 2012/07/28 06:00 [entrez]
PHST- 2012/07/28 06:00 [pubmed]
PHST- 2012/08/28 06:00 [medline]
AID - 487432a [pii]
AID - 10.1038/487432a [doi]
PST - epublish
SO  - Nature. 2012 Jul 25;487(7408):432. doi: 10.1038/487432a.


PMID- 22836845
OWN - NLM
STAT- MEDLINE
DCOM- 20121130
LR  - 20220331
IS  - 1938-808X (Electronic)
IS  - 1040-2446 (Linking)
VI  - 87
IP  - 9
DP  - 2012 Sep
TI  - Perspective: is it time for advocacy training in medical education?
PG  - 1165-70
AB  - As the modern medical system becomes increasingly complex, a debate has arisen
      over the place of advocacy efforts within the medical profession. The authors
      argue that advocacy can help physicians fulfill their social contract. For
      physicians to become competent in patient-centered, clinical, administrative, or 
      legislative advocacy, they require professional training. Many professional
      organizations have called for curricular reform to meet society's health needs
      during the past 30 years, and the inclusion of advocacy training in
      undergraduate, graduate, and continuing medical education is supported on both
      pragmatic and ethical grounds. Undergraduate medical education, especially, is an
      ideal time for this training because a standard competency can be instilled
      across all specialties. Although the Accreditation Council for Graduate Medical
      Education includes advocacy training in curricula for residency programs, few
      medical schools or residency programs have advocacy electives. By understanding
      the challenges of the health care system and how to change it for the better,
      physicians can experience increased professional satisfaction and effectiveness
      in improving patient care, systems-based practice, and public health.
FAU - Croft, Daniel
AU  - Croft D
AD  - Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA.
      Daniel.P.Croft@hitchcock.org
FAU - Jay, Stephen J
AU  - Jay SJ
FAU - Meslin, Eric M
AU  - Meslin EM
FAU - Gaffney, Margaret M
AU  - Gaffney MM
FAU - Odell, Jere D
AU  - Odell JD
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Acad Med
JT  - Academic medicine : journal of the Association of American Medical Colleges
JID - 8904605
SB  - IM
CIN - Acad Med. 2013 Jul;88(7):910. PMID: 23799435
CIN - Acad Med. 2013 Jul;88(7):910-1. PMID: 23799436
MH  - *Consumer Advocacy
MH  - Curriculum
MH  - *Education, Medical, Graduate
MH  - *Education, Medical, Undergraduate
MH  - Health Education
MH  - Health Promotion
MH  - Humans
MH  - Internship and Residency
MH  - *Physician's Role
MH  - United States
EDAT- 2012/07/28 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/28 06:00
PHST- 2012/07/28 06:00 [entrez]
PHST- 2012/07/28 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1097/ACM.0b013e31826232bc [doi]
PST - ppublish
SO  - Acad Med. 2012 Sep;87(9):1165-70. doi: 10.1097/ACM.0b013e31826232bc.


PMID- 22836808
OWN - NLM
STAT- MEDLINE
DCOM- 20130503
LR  - 20211021
IS  - 2629-3277 (Electronic)
IS  - 2629-3277 (Linking)
VI  - 8
IP  - 4
DP  - 2012 Dec
TI  - Withdrawal from biobank research: considerations and the way forward.
PG  - 1056-65
LID - 10.1007/s12015-012-9399-y [doi]
AB  - The right to withdraw one's consent after having agreed to participate in
      research is a fundamental principle in contemporary research ethics. However, it 
      has been questioned whether this right should apply to research conducted on
      donated biological samples, including stem cells and tissues from which stem
      cells can be derived. In this article we present some of the concerns that have
      been expressed related to this question. We then identify five areas that one
      needs to pay greater attention to before any conclusions can be drawn as to
      whether donors should be given the right to withdraw, or under what circumstances
      withdrawal should be allowed.
FAU - Hug, Kristina
AU  - Hug K
AD  - Lund University, Lund, Sweden. Kristina.Hug@med.lu.se
FAU - Hermeren, Goran
AU  - Hermeren G
FAU - Johansson, Mats
AU  - Johansson M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Stem Cell Rev Rep
JT  - Stem cell reviews and reports
JID - 101752767
SB  - IM
MH  - Bioethical Issues/*standards
MH  - Human Experimentation/*legislation & jurisprudence/*standards
MH  - Humans
EDAT- 2012/07/28 06:00
MHDA- 2013/05/04 06:00
CRDT- 2012/07/28 06:00
PHST- 2012/07/28 06:00 [entrez]
PHST- 2012/07/28 06:00 [pubmed]
PHST- 2013/05/04 06:00 [medline]
AID - 10.1007/s12015-012-9399-y [doi]
PST - ppublish
SO  - Stem Cell Rev Rep. 2012 Dec;8(4):1056-65. doi: 10.1007/s12015-012-9399-y.


PMID- 22836422
OWN - NLM
STAT- MEDLINE
DCOM- 20121213
LR  - 20120727
IS  - 1476-5373 (Electronic)
IS  - 0007-0610 (Linking)
VI  - 213
IP  - 2
DP  - 2012 Jul 27
TI  - The ethics of dental practice in London in the sixteenth century. 2. Sir Thomas
      More's 'Ordinances' for the Barber-Surgeons, 1530.
PG  - 77-80
LID - 10.1038/sj.bdj.2012.616 [doi]
AB  - Sir Thomas More's Ordinances can tell us much about London dental practice in the
      sixteenth century, providing an overview of training, development and practice
      within a healthcare service much like our own.
FAU - Bishop, M
AU  - Bishop M
AD  - Bulls Mill House, Hertford, UK. malcolmbishop57@btinternet.com
LA  - eng
PT  - Biography
PT  - Historical Article
PT  - Journal Article
DEP - 20120727
PL  - England
TA  - Br Dent J
JT  - British dental journal
JID - 7513219
SB  - IM
MH  - Barber Surgeons/*history
MH  - Dentistry/*standards
MH  - Ethics, Dental/*history
MH  - Famous Persons
MH  - History of Dentistry
MH  - History, 16th Century
MH  - Humans
MH  - Legislation, Dental/*history
MH  - London
PS  - More T
FPS - More, Thomas
EDAT- 2012/07/28 06:00
MHDA- 2012/12/14 06:00
CRDT- 2012/07/28 06:00
PHST- 2012/05/04 00:00 [accepted]
PHST- 2012/07/28 06:00 [entrez]
PHST- 2012/07/28 06:00 [pubmed]
PHST- 2012/12/14 06:00 [medline]
AID - sj.bdj.2012.616 [pii]
AID - 10.1038/sj.bdj.2012.616 [doi]
PST - epublish
SO  - Br Dent J. 2012 Jul 27;213(2):77-80. doi: 10.1038/sj.bdj.2012.616.


PMID- 22836222
OWN - NLM
STAT- MEDLINE
DCOM- 20130204
LR  - 20220331
IS  - 1523-4681 (Electronic)
IS  - 0884-0431 (Linking)
VI  - 27
IP  - 10
DP  - 2012 Oct
TI  - Making the first fracture the last fracture: ASBMR task force report on secondary
      fracture prevention.
PG  - 2039-46
LID - 10.1002/jbmr.1698 [doi]
AB  - Fragility fractures are common, affecting almost one in two older women and one
      in three older men. Every fragility fracture signals increased risk of future
      fractures as well as risk of premature mortality. Despite the major health care
      impact worldwide, currently there are few systems in place to identify and
      "capture" individuals after a fragility fracture to ensure appropriate assessment
      and treatment (according to national guidelines) to reduce future fracture risk
      and adverse health outcomes. The Task Force reviewed the current evidence about
      different systematic interventional approaches, their logical background, as well
      as the medical and ethical rationale. This included reviewing the evidence
      supporting cost-effective interventions and developing a toolkit for reducing
      secondary fracture incidence. This report presents this evidence for
      cost-effective interventions versus the human and health care costs associated
      with the failure to address further fractures. In particular, it summarizes the
      evidence for various forms of Fracture Liaison Service as the most effective
      intervention for secondary fracture prevention. It also summarizes the evidence
      that certain interventions, particularly those based on patient and/or
      community-focused educational approaches, are consistently, if unexpectedly,
      ineffective. As an international group, representing 36 countries throughout
      Asia-Pacific, South America, Europe, and North America, the Task Force reviewed
      and summarized the international data on barriers encountered in implementing
      risk-reduction strategies. It presents the ethical imperatives for providing
      quality of care in osteoporosis management. As part of an implementation
      strategy, it describes both the quality improvement methods best suited to
      transforming care and the research questions that remain outstanding. The
      overarching outcome of the Task Force's work has been the provision of a rational
      background and the scientific evidence underpinning secondary fracture prevention
      and stresses the utility of one form or another of a Fracture Liaison Service in 
      achieving those quality outcomes worldwide. (c) 2012 American Society for Bone
      and Mineral Research.
CI  - Copyright (c) 2012 American Society for Bone and Mineral Research.
FAU - Eisman, John A
AU  - Eisman JA
AD  - Clinical Translation and Advanced Education, Garvan Institute of Medical
      Research; University of New South Wales; St Vincent's Hospital; and School of
      Medicine Sydney, University of Notre Dame, Sydney, NSW, Australia.
      j.eisman@garvan.org.au
FAU - Bogoch, Earl R
AU  - Bogoch ER
FAU - Dell, Rick
AU  - Dell R
FAU - Harrington, J Timothy
AU  - Harrington JT
FAU - McKinney, Ross E Jr
AU  - McKinney RE Jr
FAU - McLellan, Alastair
AU  - McLellan A
FAU - Mitchell, Paul J
AU  - Mitchell PJ
FAU - Silverman, Stuart
AU  - Silverman S
FAU - Singleton, Rick
AU  - Singleton R
FAU - Siris, Ethel
AU  - Siris E
CN  - ASBMR Task Force on Secondary Fracture Prevention
LA  - eng
PT  - Journal Article
DEP - 20120726
PL  - United States
TA  - J Bone Miner Res
JT  - Journal of bone and mineral research : the official journal of the American
      Society for Bone and Mineral Research
JID - 8610640
SB  - IM
MH  - *Advisory Committees
MH  - Fractures, Bone/*prevention & control
MH  - Hip Fractures/epidemiology/prevention & control
MH  - Humans
MH  - *Research Report
MH  - *Societies, Medical
IR  - Eisman JA
FIR - Eisman, John A
IR  - Siris ES
FIR - Siris, Ethel S
IR  - Adler R
FIR - Adler, Robert
IR  - Akesson K
FIR - Akesson, Kristina
IR  - Amling M
FIR - Amling, Michael
IR  - Baim S
FIR - Baim, Sanford
IR  - Bavonratanavech S
FIR - Bavonratanavech, Suthorn
IR  - Bianchi ML
FIR - Bianchi, Maria Luisa
IR  - Bilezikian J
FIR - Bilezikian, John
IR  - Budhiparama NC
FIR - Budhiparama, Nicolaas C
IR  - Center JR
FIR - Center, Jacqueline R
IR  - Chevalley T
FIR - Chevalley, Thierry
IR  - Clark P
FIR - Clark, Patricia
IR  - Cooper C
FIR - Cooper, Cyrus
IR  - Diez-Perez A
FIR - Diez-Perez, Adolfo
IR  - Edwards BJ
FIR - Edwards, Beatrice J
IR  - Foldes AJ
FIR - Foldes, A Joseph
IR  - Fuleihan Gel-H
FIR - Fuleihan, Ghada El-Hajj
IR  - Geusens P
FIR - Geusens, Piet
IR  - Ha YC
FIR - Ha, Yong-Chan
IR  - Hagino H
FIR - Hagino, Hiroshi
IR  - Do PH
FIR - Do, Phuoc Hung
IR  - Johnson ML
FIR - Johnson, Mark L
IR  - Kung AW
FIR - Kung, Annie W C
IR  - Langdahl BL
FIR - Langdahl, Bente L
IR  - Lau E
FIR - Lau, Edith
IR  - Le AT
FIR - Le, Anh Thu
IR  - LeBoff MS
FIR - LeBoff, Meryl S
IR  - Lee JK
FIR - Lee, Joon Kiong
IR  - Lems WF
FIR - Lems, Willem F
IR  - Ling X
FIR - Ling, Xu
IR  - de Castro Machado AB
FIR - de Castro Machado, Adriana Braga
IR  - Magaziner J
FIR - Magaziner, Jay
IR  - Malhotra R
FIR - Malhotra, Rajesh
IR  - Marsh D
FIR - Marsh, David
IR  - Masri B
FIR - Masri, Basel
IR  - Mascarenhas MR
FIR - Mascarenhas, Mario Rui G
IR  - Meyer HE
FIR - Meyer, Haakon E
IR  - Mittal A
FIR - Mittal, Ambrish
IR  - Moon KH
FIR - Moon, Kyoung Ho
IR  - Moon SH
FIR - Moon, Seong-Hwan
IR  - Newman ED
FIR - Newman, Eric D
IR  - Tong P
FIR - Tong, Peijian
IR  - Recker RR
FIR - Recker, Robert R
IR  - Adolfo J
FIR - Adolfo, Jose
IR  - Portales R
FIR - Portales, Rodriguez
IR  - Saag KG
FIR - Saag, Kenneth G
IR  - Seibel MJ
FIR - Seibel, Markus J
IR  - Schelkun SR
FIR - Schelkun, Steven R
IR  - Solomon DH
FIR - Solomon, Daniel H
IR  - Stepan JJ
FIR - Stepan, Jan J
IR  - Stolnicki B
FIR - Stolnicki, Bernardo
IR  - Wang BB
FIR - Wang, B B
IR  - Won YY
FIR - Won, Ye-Yeon
IR  - De Vernejoul MC
FIR - De Vernejoul, Marie-Christine
IR  - Yang KH
FIR - Yang, Kyu Hyun
IR  - Yue D
FIR - Yue, Ding
IR  - Yoon HK
FIR - Yoon, Hyun-Koo
EDAT- 2012/07/28 06:00
MHDA- 2013/02/05 06:00
CRDT- 2012/07/28 06:00
PHST- 2012/04/03 00:00 [received]
PHST- 2012/06/11 00:00 [revised]
PHST- 2012/06/22 00:00 [accepted]
PHST- 2012/07/28 06:00 [entrez]
PHST- 2012/07/28 06:00 [pubmed]
PHST- 2013/02/05 06:00 [medline]
AID - 10.1002/jbmr.1698 [doi]
PST - ppublish
SO  - J Bone Miner Res. 2012 Oct;27(10):2039-46. doi: 10.1002/jbmr.1698. Epub 2012 Jul 
      26.


PMID- 22836196
OWN - NLM
STAT- MEDLINE
DCOM- 20121130
LR  - 20191210
IS  - 2213-0276 (Electronic)
IS  - 0755-4982 (Linking)
VI  - 41
IP  - 9 Pt 1
DP  - 2012 Sep
TI  - [The management of errors and scientific fraud by biomedical journals: They
      cannot replace Institutions].
PG  - 853-60
LID - 10.1016/j.lpm.2012.05.009 [doi]
AB  - Research integrity is not negotiable, but we regularly observe research
      misconduct, and journals are victims or guilty. Journals do not have the
      objective to assess research integrity: that's the Institutions' roles. Journals 
      discover research misconduct when articles are reviewed (an editor or a reviewer 
      detect signals), or after the article's publication when a reader or a
      whistleblower call the journal. The editors and reviewers' research misconduct
      are less described and not publicized in the medias. The peer-review system is
      criticised. If authors were fair-play, and reviews well done, the journals should
      not publish articles containing false data. The opponents to the peer-review
      system propose no alternatives to replace it. The anonymous peer reviews are
      questioned: it has never been proved that quality of anonymous reading was better
      than quality of open reading. The Open Access facilitated the creation of many
      journals. Some journals are excellent and got an impact factor; most journals
      have a poor quality and don't follow the publications ethics standards. When
      errors and fraud are identified, journals can publish 3 statements: erratum for
      errors, expression of concern for errors or fraud when evidence is not
      established, and retraction when evidence is obvious.
CI  - Copyright (c) 2012 Elsevier Masson SAS. All rights reserved.
FAU - Maisonneuve, Herve
AU  - Maisonneuve H
AD  - Faculte de medecine Paris-Sud 11, departement de sante publique, d'evaluation et 
      d'information medicale, 63, rue Gabriel-Peri, 94277 Le Kremlin-Bicetre, France.
      hervemaisonneuve@gmail.com
LA  - fre
PT  - Journal Article
TT  - Le management des erreurs et fraudes scientifiques par les revues biomedicales : 
      elles ne peuvent pas se substituer aux institutions.
DEP - 20120724
PL  - France
TA  - Presse Med
JT  - Presse medicale (Paris, France : 1983)
JID - 8302490
SB  - IM
MH  - Access to Information
MH  - Authorship
MH  - Codes of Ethics
MH  - Duplicate Publications as Topic
MH  - *Editorial Policies
MH  - Ethics, Research
MH  - Fraud/prevention & control
MH  - Guidelines as Topic
MH  - Humans
MH  - Information Dissemination
MH  - Journal Impact Factor
MH  - Peer Review, Research
MH  - *Periodicals as Topic
MH  - Plagiarism
MH  - Research Design
MH  - Retraction of Publication as Topic
MH  - *Scientific Misconduct
EDAT- 2012/07/28 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/28 06:00
PHST- 2012/05/14 00:00 [received]
PHST- 2012/05/15 00:00 [accepted]
PHST- 2012/07/28 06:00 [entrez]
PHST- 2012/07/28 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - S0755-4982(12)00362-4 [pii]
AID - 10.1016/j.lpm.2012.05.009 [doi]
PST - ppublish
SO  - Presse Med. 2012 Sep;41(9 Pt 1):853-60. doi: 10.1016/j.lpm.2012.05.009. Epub 2012
      Jul 24.


PMID- 22835449
OWN - NLM
STAT- MEDLINE
DCOM- 20121210
LR  - 20121001
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 98
IP  - 4
DP  - 2012 Oct
TI  - Using family members as gamete donors or surrogates.
PG  - 797-803
LID - 10.1016/j.fertnstert.2012.06.046 [doi]
LID - S0015-0282(12)00699-1 [pii]
AB  - The use of intrafamilial gamete donors and surrogates is generally ethically
      acceptable when all participants are fully informed and counseled, but
      arrangements that replicate the results of true consanguineous or incestuous
      unions should be prohibited, child to parent arrangements are generally
      unacceptable, and parent to child arrangements are acceptable in limited
      situations. Programs that choose to participate in intrafamilial arrangements
      should be prepared to spend additional time counseling participants and ensuring 
      that they have made free, informed decisions.
CI  - Copyright (c) 2012 American Society for Reproductive Medicine. Published by
      Elsevier Inc. All rights reserved.
CN  - Ethics Committee of the American Society for Reproductive Medicine
LA  - eng
PT  - Journal Article
DEP - 20120724
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
SB  - IM
MH  - *Consanguinity
MH  - Cooperative Behavior
MH  - Counseling/ethics
MH  - Directed Tissue Donation/*ethics
MH  - Education, Medical, Continuing
MH  - Ethics Committees/*ethics
MH  - *Family
MH  - Female
MH  - Humans
MH  - Infertility/therapy
MH  - Male
MH  - Pregnancy
MH  - Reproductive Medicine/*ethics
MH  - Surrogate Mothers
IR  - Amato P
FIR - Amato, Paula
IR  - Brzyski R
FIR - Brzyski, Robert
IR  - Braverman A
FIR - Braverman, Andrea
IR  - Benward J
FIR - Benward, Jean
IR  - Stein A
FIR - Stein, Andrea
IR  - Steinbock B
FIR - Steinbock, Bonnie
IR  - Wilder B
FIR - Wilder, Bruce
IR  - Reindollar R
FIR - Reindollar, Richard
IR  - Lamb D
FIR - Lamb, Dolores
IR  - Robertson J
FIR - Robertson, John
IR  - Daar J
FIR - Daar, Judith
IR  - Francis L
FIR - Francis, Leslie
IR  - Gibson M
FIR - Gibson, Mark
IR  - Fisseha S
FIR - Fisseha, Senait
IR  - Ralston S
FIR - Ralston, Steven
IR  - Sauer M
FIR - Sauer, Mark
IR  - Spillman M
FIR - Spillman, Monique
IR  - Rebar R
FIR - Rebar, Robert
IR  - Tipton S
FIR - Tipton, Sean
EDAT- 2012/07/28 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/07/28 06:00
PHST- 2012/06/20 00:00 [received]
PHST- 2012/06/22 00:00 [accepted]
PHST- 2012/07/28 06:00 [entrez]
PHST- 2012/07/28 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - S0015-0282(12)00699-1 [pii]
AID - 10.1016/j.fertnstert.2012.06.046 [doi]
PST - ppublish
SO  - Fertil Steril. 2012 Oct;98(4):797-803. doi: 10.1016/j.fertnstert.2012.06.046.
      Epub 2012 Jul 24.


PMID- 22834878
OWN - NLM
STAT- MEDLINE
DCOM- 20130206
LR  - 20151119
IS  - 1365-2702 (Electronic)
IS  - 0962-1067 (Linking)
VI  - 21
IP  - 19-20
DP  - 2012 Oct
TI  - A Rasch analysis of nurses' ethical sensitivity to the norms of the code of
      conduct.
PG  - 2747-60
LID - 10.1111/j.1365-2702.2012.04137.x [doi]
AB  - AIMS AND OBJECTIVES: To develop an instrument to measure nurses' ethical
      sensitivity and, secondarily, to use this instrument to compare nurses' ethical
      sensitivity between groups. BACKGROUND: Professional codes of conduct are widely 
      accepted guidelines. However, their efficacy in daily nursing practice and
      influence on ethical sensitivity is controversial. DESIGN: A descriptive
      cross-sectional study was conducted. PARTICIPANTS: One hundred and forty-three
      registered nurses from Barcelona (Spain) participated in the study, of whom
      45.83% were working in primary health care and 53.84% in hospital wards. METHODS:
      A specifically designed confidential, self-administered questionnaire assessing
      ethical sensitivity was developed. Knowledge of the nursing code and data on
      ethical sensitivity were summarised, with the quality of the questionnaire
      assessed using Rasch analysis. RESULTS: Item on knowledge of the code showed that
      one-third of nurses knew the contents of the code and two-thirds had limited
      knowledge. To fit the Rasch model, it was necessary to rescore the rating scale
      from five to three categories. Residual principal components analysis confirmed
      the unidimensionality of the scale. Three items of the questionnaire presented
      fit problems with the Rasch model. Although nurses generally have high ethical
      sensitivity to their code of conduct, differences were found according to years
      of professional practice, place of work and knowledge of the code (p<0.05).
      CONCLUSIONS: The questionnaire showed acceptable psychometric properties to
      achieve the proposed objective. Nurses' ethical sensitivity to the norms of the
      code was high. However, many factors might influence the degree of ethical
      sensitivity. Further research to measure ethical sensitivity using invariant
      measures such as Rasch units would be valuable. RELEVANCE TO CLINICAL PRACTICE:
      Other factors, such as assertiveness or courage, should be considered to improve 
      ethical sensitivity to the code of conduct. Rigorous measurement studies and
      analysis in applied ethics are needed to assess ethical performance in practice.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Gonzalez-de Paz, Luis
AU  - Gonzalez-de Paz L
AD  - Les Corts Primary Health Care Centre, PHC Research Group-IDIBAPS, Barcelona,
      Spain. gonzalezdepaz@hotmail.com
FAU - Kostov, Belchin
AU  - Kostov B
FAU - Siso-Almirall, Antoni
AU  - Siso-Almirall A
FAU - Zabalegui-Yarnoz, Adela
AU  - Zabalegui-Yarnoz A
LA  - eng
PT  - Journal Article
DEP - 20120727
PL  - England
TA  - J Clin Nurs
JT  - Journal of clinical nursing
JID - 9207302
MH  - Adult
MH  - Cross-Sectional Studies
MH  - *Ethics, Nursing
MH  - Guidelines as Topic
MH  - Humans
MH  - Middle Aged
MH  - Spain
MH  - Surveys and Questionnaires
EDAT- 2012/07/28 06:00
MHDA- 2013/02/07 06:00
CRDT- 2012/07/28 06:00
PHST- 2012/07/28 06:00 [entrez]
PHST- 2012/07/28 06:00 [pubmed]
PHST- 2013/02/07 06:00 [medline]
AID - 10.1111/j.1365-2702.2012.04137.x [doi]
PST - ppublish
SO  - J Clin Nurs. 2012 Oct;21(19-20):2747-60. doi: 10.1111/j.1365-2702.2012.04137.x.
      Epub 2012 Jul 27.


PMID- 22834791
OWN - NLM
STAT- MEDLINE
DCOM- 20140121
LR  - 20130712
IS  - 1471-6712 (Electronic)
IS  - 0283-9318 (Linking)
VI  - 27
IP  - 3
DP  - 2013 Sep
TI  - Experiences of the individual placement and support approach in persons with
      severe mental illness.
PG  - 589-96
LID - 10.1111/j.1471-6712.2012.01056.x [doi]
AB  - BACKGROUND: Across several research studies comparing the individual placement
      and support (IPS) approach to traditional vocational services, the approach has
      achieved employment outcomes superior to comparison conditions. However, to
      understand the efficacy of IPS, it is equally important to consider what is more 
      or less effective as viewed by the IPS participants. AIM: To investigate
      participants' experiences of IPS participation and their experiences of receiving
      support from an employment specialist (ES). METHOD: Interviews were conducted
      with 17 persons with severe mental illness. The interviews were subjected to
      qualitative content analysis. The principles of informed consent and the
      voluntary nature of participation were included as ethical considerations.
      RESULTS: Participation in IPS was associated with hope, meaning and an
      individualized support provided by the ES. The skills of the ES facilitated the
      relationship with the participant and the contact with the labour market.
      However, to make a change happen, everybody involved in IPS had to contribute.
      CONCLUSION: These findings have endorsed the guiding principles of IPS and
      emphasized the ES's role and skills during IPS as well as the participant's
      motivation.
CI  - (c) 2012 The Authors. Scandinavian Journal of Caring Sciences (c) 2012 Nordic
      College of Caring Science.
FAU - Areberg, Cecilia
AU  - Areberg C
AD  - Department of Health Sciences, Division of Occupational Therapy and Gerontology, 
      Lund University & The Swedish Institute for Health Sciences, Lund University,
      Lund, Sweden. cecilia.areberg@med.lu.se
FAU - Bjorkman, Tommy
AU  - Bjorkman T
FAU - Bejerholm, Ulrika
AU  - Bejerholm U
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20120727
PL  - Sweden
TA  - Scand J Caring Sci
JT  - Scandinavian journal of caring sciences
JID - 8804206
MH  - Adult
MH  - Female
MH  - Humans
MH  - Male
MH  - Mental Disorders/*therapy
MH  - Middle Aged
MH  - Severity of Illness Index
MH  - Sweden
MH  - Young Adult
OTO - NOTNLM
OT  - employment specialist
OT  - service users
OT  - supported employment
EDAT- 2012/07/28 06:00
MHDA- 2014/01/22 06:00
CRDT- 2012/07/28 06:00
PHST- 2012/07/28 06:00 [entrez]
PHST- 2012/07/28 06:00 [pubmed]
PHST- 2014/01/22 06:00 [medline]
AID - 10.1111/j.1471-6712.2012.01056.x [doi]
PST - ppublish
SO  - Scand J Caring Sci. 2013 Sep;27(3):589-96. doi: 10.1111/j.1471-6712.2012.01056.x.
      Epub 2012 Jul 27.


PMID- 22834691
OWN - NLM
STAT- MEDLINE
DCOM- 20130205
LR  - 20211021
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 13
DP  - 2012 Jul 26
TI  - What is the role and authority of gatekeepers in cluster randomized trials in
      health research?
PG  - 116
LID - 10.1186/1745-6215-13-116 [doi]
AB  - This article is part of a series of papers examining ethical issues in cluster
      randomized trials (CRTs) in health research. In the introductory paper in this
      series, we set out six areas of inquiry that must be addressed if the CRT is to
      be set on a firm ethical foundation. This paper addresses the sixth of the
      questions posed, namely, what is the role and authority of gatekeepers in CRTs in
      health research? 'Gatekeepers' are individuals or bodies that represent the
      interests of cluster members, clusters, or organizations. The need for
      gatekeepers arose in response to the difficulties in obtaining informed consent
      because of cluster randomization, cluster-level interventions, and cluster size. 
      In this paper, we call for a more restrictive understanding of the role and
      authority of gatekeepers.Previous papers in this series have provided solutions
      to the challenges posed by informed consent in CRTs without the need to invoke
      gatekeepers. We considered that consent to randomization is not required when
      cluster members are approached for consent at the earliest opportunity and before
      any study interventions or data-collection procedures have started. Further, when
      cluster-level interventions or cluster size means that obtaining informed consent
      is not possible, a waiver of consent may be appropriate. In this paper, we
      suggest that the role of gatekeepers in protecting individual interests in CRTs
      should be limited. Generally, gatekeepers do not have the authority to provide
      proxy consent for cluster members. When a municipality or other community has a
      legitimate political authority that is empowered to make such decisions, cluster 
      permission may be appropriate; however, gatekeepers may usefully protect cluster 
      interests in other ways. Cluster consultation may ensure that the CRT addresses
      local health needs, and is conducted in accord with local values and customs.
      Gatekeepers may also play an important role in protecting the interests of
      organizations, such as hospitals, nursing homes, general practices, and schools. 
      In these settings, permission to access the organization relies on resource
      implications and adherence to institutional policies.
FAU - Gallo, Antonio
AU  - Gallo A
AD  - Rotman Institute of Philosophy, University of Western Ontario, London, ON N6A
      5B8, Canada.
FAU - Weijer, Charles
AU  - Weijer C
FAU - White, Angela
AU  - White A
FAU - Grimshaw, Jeremy M
AU  - Grimshaw JM
FAU - Boruch, Robert
AU  - Boruch R
FAU - Brehaut, Jamie C
AU  - Brehaut JC
FAU - Donner, Allan
AU  - Donner A
FAU - Eccles, Martin P
AU  - Eccles MP
FAU - McRae, Andrew D
AU  - McRae AD
FAU - Saginur, Raphael
AU  - Saginur R
FAU - Zwarenstein, Merrick
AU  - Zwarenstein M
FAU - Taljaard, Monica
AU  - Taljaard M
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120726
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
SB  - IM
MH  - Cluster Analysis
MH  - Decision Making
MH  - *Health Personnel/ethics
MH  - Health Services Research/ethics/*methods
MH  - Humans
MH  - *Informed Consent/ethics
MH  - *Patient Selection/ethics
MH  - *Professional Role
MH  - Proxy
MH  - Randomized Controlled Trials as Topic/ethics/*methods
MH  - *Research Design
MH  - Sample Size
PMC - PMC3443001
EDAT- 2012/07/28 06:00
MHDA- 2013/02/06 06:00
CRDT- 2012/07/28 06:00
PHST- 2011/11/10 00:00 [received]
PHST- 2012/07/26 00:00 [accepted]
PHST- 2012/07/28 06:00 [entrez]
PHST- 2012/07/28 06:00 [pubmed]
PHST- 2013/02/06 06:00 [medline]
AID - 1745-6215-13-116 [pii]
AID - 10.1186/1745-6215-13-116 [doi]
PST - epublish
SO  - Trials. 2012 Jul 26;13:116. doi: 10.1186/1745-6215-13-116.


PMID- 22834650
OWN - NLM
STAT- MEDLINE
DCOM- 20131206
LR  - 20220409
IS  - 1471-6712 (Electronic)
IS  - 0283-9318 (Linking)
VI  - 27
IP  - 2
DP  - 2013 Jun
TI  - The substance of love when encountering suffering: an interpretative research
      synthesis with an abductive approach.
PG  - 449-59
LID - 10.1111/j.1471-6712.2012.01038.x [doi]
AB  - AIM: This study presents the results of an interpretative research synthesis
      undertaken to explore the essence of love when encountering suffering. The idea
      of caring as an expression of love and compassion belongs with ideas that have
      shaped caring for hundreds of years. Love and suffering are the core concepts in 
      caring science and thus demand a basic research approach. METHODS: The synthesis 
      was undertaken by the interpretation of 15 articles focusing on love in different
      aspects, but within a caring science perspective. The research process was guided
      by a hermeneutical perspective with an abductive approach. RESULTS: The substance
      of love, when encountering suffering, reveals itself in three themes: love as a
      holy power, love as fundamental for being and love as an ethical act, which are
      to be found, respectively, within three dimensions: love as holiness, love as a
      communion and love as an art. Love is a holy power and encompasses everything; it
      is the well of strength that heals. No human can exist without love: this points 
      to the ethical responsibility one has as a neighbour. In the ethical act, love is
      evident in concrete caring actions. CONCLUSIONS: The core of the substance of
      love within the three dimensions can be understood as agape. Agape connects and
      mirrors the dimensions, while at the same time it is clear that agape stems from 
      and moves towards holiness, enabling love to be the ethical foundation when
      encountering suffering. Through the dimensions of love as communion and love as
      an art agape intertwine with eros forming caritas enabling the human being to
      move towards the dimension of holiness, which signifies becoming through
      suffering.
CI  - (c) 2012 Nordic College of Caring Science.
FAU - Thorkildsen, Kari Marie
AU  - Thorkildsen KM
AD  - Faculty of Caring Science, Abo Akademi University, Vaasa, Finland and Faculty of 
      Health Stord/ Haugesund University College, Stord, Norway.
      kari.thorkildsen@hsh.no
FAU - Eriksson, Katie
AU  - Eriksson K
FAU - Raholm, Maj-Britt
AU  - Raholm MB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120727
PL  - Sweden
TA  - Scand J Caring Sci
JT  - Scandinavian journal of caring sciences
JID - 8804206
MH  - *Health Services Research
MH  - Humans
MH  - *Love
MH  - Stress, Psychological/*physiopathology
EDAT- 2012/07/28 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/07/28 06:00
PHST- 2012/07/28 06:00 [entrez]
PHST- 2012/07/28 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1111/j.1471-6712.2012.01038.x [doi]
PST - ppublish
SO  - Scand J Caring Sci. 2013 Jun;27(2):449-59. doi: 10.1111/j.1471-6712.2012.01038.x.
      Epub 2012 Jul 27.


PMID- 22834210
OWN - NLM
STAT- MEDLINE
DCOM- 20120823
LR  - 20120727
IS  - 0023-7205 (Print)
IS  - 0023-7205 (Linking)
VI  - 109
IP  - 23-24
DP  - 2012 Jun 5-19
TI  - [Integrated teaching of ethics of value in the medical education].
PG  - 1167-9
FAU - Bjorck, Erik
AU  - Bjorck E
AD  - Karolinska universitetssjukhuset, Karolinska institutet.
FAU - Juth, Niklas
AU  - Juth N
FAU - Marions, Lena
AU  - Marions L
LA  - swe
PT  - Journal Article
TT  - Integrerad undervisning i etik av varde pa laikarutbildningen.
PL  - Sweden
TA  - Lakartidningen
JT  - Lakartidningen
JID - 0027707
SB  - IM
MH  - Clinical Competence
MH  - *Education, Medical
MH  - Ethics, Medical/*education
MH  - Humans
EDAT- 2012/07/28 06:00
MHDA- 2012/08/24 06:00
CRDT- 2012/07/28 06:00
PHST- 2012/07/28 06:00 [entrez]
PHST- 2012/07/28 06:00 [pubmed]
PHST- 2012/08/24 06:00 [medline]
PST - ppublish
SO  - Lakartidningen. 2012 Jun 5-19;109(23-24):1167-9.


PMID- 22834093
OWN - NLM
STAT- MEDLINE
DCOM- 20121009
LR  - 20151119
IS  - 0546-1766 (Print)
IS  - 0546-1766 (Linking)
VI  - 59
IP  - 6
DP  - 2012 Jun
TI  - [Relationship between pregnant women's sensitivity to cold (hiesho) and premature
      labor assessed using propensity scores for adjusting confounding factors].
PG  - 381-9
AB  - OBJECTIVES: The purpose of this study is to analyze the influence of sensitivity 
      to cold or hiesho in pregnant Japanese women and to examine the relationship
      between hiesho and premature labor. METHODS: In this retrospective cohort study
      in Japanese women after delivery, information for the approximately 12 months
      between October 19, 2009 and October 8, 2010 was obtained using questionnaire
      surveys and medical records at 6 hospitals with obstetric and pediatric
      departments in the Greater Tokyo Metropolitan Area. Further, in this analysis,
      confounding factors were adjusted by performing analysis of covariance and
      stratified analysis using propensity scores. The Research Ethics Review Committee
      of St. Luke's College of Nursing (09-057) approved this study. RESULTS: Analysis 
      of data from 2,810 women was performed. Regarding the correlation between hiesho 
      and premature labor, the incidence of premature labor was 3.38 times higher
      (analysis of covariance) or 3.47 times higher (stratified analysis) among
      pregnant women with hiesho than among those without hiesho (P < 0.001). The
      results of this study proved the existing discussions that there is a correlation
      between hiesho CONCLUSION: during the latter stages of pregnancy and incidence of
      premature labor.
FAU - Nakamura, Sachiyo
AU  - Nakamura S
AD  - Keio University.
FAU - Horiuchi, Shigeko
AU  - Horiuchi S
FAU - Yanai, Haruo
AU  - Yanai H
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Nihon Koshu Eisei Zasshi
JT  - [Nihon koshu eisei zasshi] Japanese journal of public health
JID - 19130150R
SB  - IM
MH  - Adult
MH  - *Cold Temperature
MH  - Female
MH  - Humans
MH  - Obstetric Labor, Premature/*etiology
MH  - Pregnancy
MH  - Retrospective Studies
MH  - Surveys and Questionnaires
MH  - Thermosensing
EDAT- 2012/07/28 06:00
MHDA- 2012/10/10 06:00
CRDT- 2012/07/28 06:00
PHST- 2012/07/28 06:00 [entrez]
PHST- 2012/07/28 06:00 [pubmed]
PHST- 2012/10/10 06:00 [medline]
PST - ppublish
SO  - Nihon Koshu Eisei Zasshi. 2012 Jun;59(6):381-9.


PMID- 22834048
OWN - HMD
STAT- MEDLINE
DCOM- 20121003
LR  - 20191027
IS  - 0012-3846 (Print)
IS  - 0012-3846 (Linking)
VI  - 59
IP  - 2
DP  - 2012
TI  - Making choices: ethics and vegetarianism.
PG  - 39-41
AB  - I was seventeen and taking an elective course in Earth and Environmental Science.
      We were learning about farming and the food system-genetic modification, land
      use, organic labeling-when our teacher assigned us an article about beef. The
      article explained the following process: the U.S. government subsidizes corn, so 
      we feed it to our cows, because corn is cheap and fattens the cows up quickly.
      Cows are biologically designed to eat grass, so their livers are unable to
      process the corn. The cows' livers would actually explode if they were permitted 
      to grow to full maturity, but we slaughter them first. This, combined with their 
      living in close quarters and wading in their own feces, causes the cows to get
      ill often, so we feed them a con-stant stream of antibiotics, a practice that
      strengthens bacterial strains such as E. coli. Roughly 78 percent of cows raised 
      for beef undergo this process. Similarly nauseating practices are used to raise
      chickens, turkeys, and pigs, 99 percent, 97 percent, and 95 percent of which,
      respectively, come from factory farms. Nowadays, these details are less than
      shocking. Movies such as Food, Inc. and Super Size Me, as well as books such as
      The Omnivore's Dilemma and Fast Food Nation have raised consciousness, if not
      much action, on the topic of our food system. But, for me, it was a new story.
FAU - Devries, Juliana
AU  - Devries J
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - Dissent
JT  - Dissent
JID - 100967488
MH  - *Diet, Vegetarian/economics/ethnology/history/psychology
MH  - *Ethics/history
MH  - *Food Industry/economics/education/history/legislation & jurisprudence
MH  - Food Supply/economics/history/legislation & jurisprudence
MH  - History, 20th Century
MH  - History, 21st Century
MH  - *Meat Products/economics/history
MH  - United States/ethnology
EDAT- 2012/07/28 06:00
MHDA- 2012/10/04 06:00
CRDT- 2012/07/28 06:00
PHST- 2012/07/28 06:00 [entrez]
PHST- 2012/07/28 06:00 [pubmed]
PHST- 2012/10/04 06:00 [medline]
AID - 10.1353/dss.2012.0045 [doi]
PST - ppublish
SO  - Dissent. 2012;59(2):39-41. doi: 10.1353/dss.2012.0045.


PMID- 22834029
STAT- Publisher
DA  - 20120727
PB  - Agency for Healthcare Research and Quality (US)
CTI - AHRQ Methods for Effective Health Care
DP  - 2012 Jun
TI  - Choosing the Important Outcomes for a Systematic Review of a Medical Test
BTI - Methods Guide for Medical Test Reviews
CP  - Chapter 3
AB  - In this chapter of the Evidence-based Practice Centers Methods Guide for Medical 
      Test Reviews, we describe how the decision to use a medical test generates a
      broad range of outcomes, and suggest how each of these outcomes might be
      considered for inclusion in a systematic review. Awareness of these varied
      outcomes affects how a decisionmaker balances the benefits and risks of the test;
      therefore, a systematic review should present the evidence on their diversity.
      The key outcome categories include clinical management outcomes; direct health
      effects; emotional, social, cognitive, and behavioral responses to testing; legal
      and ethical outcomes; and costs. We describe the challenges of incorporating
      these outcomes in a systematic review, suggest a framework for generating
      potential outcomes for inclusion, and describe the role of stakeholders in
      choosing the outcomes for study. Finally, we give examples of systematic reviews 
      that either included a range of outcomes or that might have done so. This chapter
      puts forward a set of key messages for systematic reviewers: Consider both the
      outcomes that are relevant to the process of testing and those relevant to the
      results of the test. Consider inclusion of outcomes in all five domains: clinical
      management effects; direct test effects; emotional, social, cognitive, and
      behavioral effects; legal and ethical effects; and costs. Consider to which group
      the outcomes of testing are most relevant. Given resource limitations, prioritize
      which outcomes to include. This decision depends on the needs of the
      stakeholder(s), who should be assisted in prioritizing the outcomes for
      inclusion.
FED - Chang, Stephanie M
ED  - Chang SM
FED - Matchar, David B
ED  - Matchar DB
FED - Smetana, Gerald W
ED  - Smetana GW
FED - Umscheid, Craig A
ED  - Umscheid CA
FAU - Segal, Jodi B
AU  - Segal JB
LA  - eng
PT  - Review
PT  - Book Chapter
PL  - Rockville (MD)
EDAT- 2012/07/27 06:00
MHDA- 2012/07/27 06:00
CDAT- 2012/07/27 06:00
AID - NBK98236 [bookaccession]


PMID- 22833864
OWN - HMD
STAT- MEDLINE
DCOM- 20121003
LR  - 20211021
IS  - 0098-7921 (Print)
IS  - 0098-7921 (Linking)
VI  - 38
IP  - 1
DP  - 2012
TI  - The Latin American cohabitation boom, 1970-2007.
PG  - 55-81
AB  - The article describes the rise of unmarried cohabitation in Latin American
      countries during the last 30 years of the twentieth century, both at the national
      and regional levels. It documents that this major increase occurred in regions
      with and without traditional forms of cohabitation alike. In addition, the
      striking degree of catching up of cohabitation among the better-educated
      population segments is illustrated. The connections between these trends and
      economic (periods of high inflation) and cultural (reduction of stigmas in
      ethical domains) factors are discussed. The conclusion is that the periods of
      inflation and hyperinflation may have been general catalysts, but no clear
      indications of correlation were found between such economic factors and the rise 
      in cohabitation. The shift toward more tolerance for hitherto stigmatized forms
      of conduct (e.g., homosexuality, euthanasia, abortion, singleparent household) is
      in line with the rise of cohabitation in regions of Argentina, Chile, and Brazil 
      where cohabitation used to be uncommon. Further rises in cohabitation during the 
      first decade of the twenty-first century are expected in a number of countries
      (e.g., mexico) despite conditions of much lower inflation.
FAU - Esteve, Albert
AU  - Esteve A
AD  - Center for Demographic Studies (CED), Universitat Autonoma de Barcelona.
FAU - Lesthaeghe, Ron
AU  - Lesthaeghe R
FAU - Lopez-Gay, Antonio
AU  - Lopez-Gay A
LA  - eng
GR  - R01 HD044154/HD/NICHD NIH HHS/United States
GR  - R24 HD041023/HD/NICHD NIH HHS/United States
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - Popul Dev Rev
JT  - Population and development review
JID - 7613927
MH  - *Cultural Characteristics/history
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Latin America/ethnology
MH  - *Residence Characteristics/history
MH  - *Single Person/education/history/legislation & jurisprudence/psychology
MH  - *Social Behavior/history
MH  - *Socioeconomic Factors/history
PMC - PMC3500917
MID - NIHMS387600
EDAT- 2012/07/27 06:00
MHDA- 2012/10/04 06:00
CRDT- 2012/07/27 06:00
PHST- 2012/07/27 06:00 [entrez]
PHST- 2012/07/27 06:00 [pubmed]
PHST- 2012/10/04 06:00 [medline]
AID - 10.1111/j.1728-4457.2012.00472.x [doi]
PST - ppublish
SO  - Popul Dev Rev. 2012;38(1):55-81. doi: 10.1111/j.1728-4457.2012.00472.x.


PMID- 22833821
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 2077-6624 (Electronic)
IS  - 2072-1439 (Linking)
VI  - 4
IP  - 2
DP  - 2012 Apr 1
TI  - Whole genome sequencing for lung cancer.
PG  - 155-63
LID - 10.3978/j.issn.2072-1439.2012.02.01 [doi]
AB  - Lung cancer is a leading cause of cancer related morbidity and mortality
      globally, and carries a dismal prognosis. Improved understanding of the biology
      of cancer is required to improve patient outcomes. Next-generation sequencing
      (NGS) is a powerful tool for whole genome characterisation, enabling
      comprehensive examination of somatic mutations that drive oncogenesis. Most NGS
      methods are based on polymerase chain reaction (PCR) amplification of
      platform-specific DNA fragment libraries, which are then sequenced. These
      techniques are well suited to high-throughput sequencing and are able to detect
      the full spectrum of genomic changes present in cancer. However, they require
      considerable investments in time, laboratory infrastructure, computational
      analysis and bioinformatic support. Next-generation sequencing has been applied
      to studies of the whole genome, exome, transcriptome and epigenome, and is
      changing the paradigm of lung cancer research and patient care. The results of
      this new technology will transform current knowledge of oncogenic pathways and
      provide molecular targets of use in the diagnosis and treatment of cancer.
      Somatic mutations in lung cancer have already been identified by NGS, and large
      scale genomic studies are underway. Personalised treatment strategies will
      improve care for those likely to benefit from available therapies, while sparing 
      others the expense and morbidity of futile intervention. Organisational,
      computational and bioinformatic challenges of NGS are driving technological
      advances as well as raising ethical issues relating to informed consent and data 
      release. Differentiation between driver and passenger mutations requires careful 
      interpretation of sequencing data. Challenges in the interpretation of results
      arise from the types of specimens used for DNA extraction, sample processing
      techniques and tumour content. Tumour heterogeneity can reduce power to detect
      mutations implicated in oncogenesis. Next-generation sequencing will facilitate
      investigation of the biological and clinical implications of such variation.
      These techniques can now be applied to single cells and free circulating DNA, and
      possibly in the future to DNA obtained from body fluids and from subpopulations
      of tumour. As costs reduce, and speed and processing accuracy increase, NGS
      technology will become increasingly accessible to researchers and clinicians,
      with the ultimate goal of improving the care of patients with lung cancer.
FAU - Daniels, Marissa
AU  - Daniels M
FAU - Goh, Felicia
AU  - Goh F
FAU - Wright, Casey M
AU  - Wright CM
FAU - Sriram, Krishna B
AU  - Sriram KB
FAU - Relan, Vandana
AU  - Relan V
FAU - Clarke, Belinda E
AU  - Clarke BE
FAU - Duhig, Edwina E
AU  - Duhig EE
FAU - Bowman, Rayleen V
AU  - Bowman RV
FAU - Yang, Ian A
AU  - Yang IA
FAU - Fong, Kwun M
AU  - Fong KM
LA  - eng
PT  - Journal Article
PL  - China
TA  - J Thorac Dis
JT  - Journal of thoracic disease
JID - 101533916
PMC - PMC3378223
OTO - NOTNLM
OT  - DNA sequence analysis
OT  - High-throughput nucleotide sequencing
OT  - lung neoplasms
OT  - non-small cell lung carcinoma
OT  - small cell lung carcinoma
EDAT- 2012/07/27 06:00
MHDA- 2012/07/27 06:01
CRDT- 2012/07/27 06:00
PHST- 2012/01/02 00:00 [received]
PHST- 2012/02/01 00:00 [accepted]
PHST- 2012/07/27 06:00 [entrez]
PHST- 2012/07/27 06:00 [pubmed]
PHST- 2012/07/27 06:01 [medline]
AID - 10.3978/j.issn.2072-1439.2012.02.01 [doi]
AID - jtd-04-02-155 [pii]
PST - ppublish
SO  - J Thorac Dis. 2012 Apr 1;4(2):155-63. doi: 10.3978/j.issn.2072-1439.2012.02.01.


PMID- 22833756
OWN - NLM
STAT- MEDLINE
DCOM- 20130110
LR  - 20220310
IS  - 1866-0452 (Electronic)
IS  - 1866-0452 (Linking)
VI  - 109
IP  - 26
DP  - 2012 Jun
TI  - Nocebo phenomena in medicine: their relevance in everyday clinical practice.
PG  - 459-65
LID - 10.3238/arztebl.2012.0459 [doi]
AB  - BACKGROUND: Nocebo phenomena are common in clinical practice and have recently
      become a popular topic of research and discussion among basic scientists,
      clinicians, and ethicists. METHODS: We selectively searched the PubMed database
      for articles published up to December 2011 that contained the key words "nocebo" 
      or "nocebo effect." RESULTS: By definition, a nocebo effect is the induction of a
      symptom perceived as negative by sham treatment and/or by the suggestion of
      negative expectations. A nocebo response is a negative symptom induced by the
      patient's own negative expectations and/or by negative suggestions from clinical 
      staff in the absence of any treatment. The underlying mechanisms include learning
      by Pavlovian conditioning and reaction to expectations induced by verbal
      information or suggestion. Nocebo responses may come about through unintentional 
      negative suggestion on the part of physicians and nurses. Information about
      possible complications and negative expectations on the patient's part increases 
      the likelihood of adverse effects. Adverse events under treatment with
      medications sometimes come about by a nocebo effect. CONCLUSION: Physicians face 
      an ethical dilemma, as they are required not just to inform patients of the
      potential complications of treatment, but also to minimize the likelihood of
      these complications, i.e., to avoid inducing them through the potential nocebo
      effect of thorough patient information. Possible ways out of the dilemma include 
      emphasizing the fact that the proposed treatment is usually well tolerated, or
      else getting the patient's permission to inform less than fully about its
      possible side effects. Communication training in medical school, residency
      training, and continuing medical education would be desirable so that physicians 
      can better exploit the power of words to patients' benefit, rather than their
      detriment.
FAU - Hauser, Winfried
AU  - Hauser W
AD  - Department of Internal Medicine I, Klinikum Saarbrucken, Saarbrucken, Germany.
      whaeuser@klinikum-saarbruecken.de
FAU - Hansen, Ernil
AU  - Hansen E
FAU - Enck, Paul
AU  - Enck P
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120629
PL  - Germany
TA  - Dtsch Arztebl Int
JT  - Deutsches Arzteblatt international
JID - 101475967
SB  - IM
CIN - Dtsch Arztebl Int. 2013 Jan;110(4):58. PMID: 23413389
CIN - Dtsch Arztebl Int. 2013 Jan;110(4):58. PMID: 23413390
MH  - *Anticipation, Psychological
MH  - Drug-Related Side Effects and Adverse Reactions/*epidemiology/*prevention &
      control/psychology
MH  - Humans
MH  - Informed Consent/*ethics/psychology/*statistics & numerical data
MH  - Physician-Patient Relations/*ethics
MH  - *Placebo Effect
MH  - Prevalence
PMC - PMC3401955
EDAT- 2012/07/27 06:00
MHDA- 2013/01/11 06:00
CRDT- 2012/07/27 06:00
PHST- 2012/01/28 00:00 [received]
PHST- 2012/03/28 00:00 [accepted]
PHST- 2012/07/27 06:00 [entrez]
PHST- 2012/07/27 06:00 [pubmed]
PHST- 2013/01/11 06:00 [medline]
AID - 10.3238/arztebl.2012.0459 [doi]
PST - ppublish
SO  - Dtsch Arztebl Int. 2012 Jun;109(26):459-65. doi: 10.3238/arztebl.2012.0459. Epub 
      2012 Jun 29.


PMID- 22833694
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 0717-5906 (Print)
IS  - 0717-5906 (Linking)
VI  - 18
IP  - 1
DP  - 2012
PG  - 57-62
AB  - This article reflects on the ten years experience of group learning processes and
      skills acquisition by trainees of the ethics of biomedical and psychosocial
      research international training program from the Interdisciplinary Center for
      Studies on Bioethics of the University of Chile, Fogarty Grant R25TW6056. It
      takes into consideration the role of bioethics in training in its
      transdisciplinary character.
FAU - Rodriguez, Eduardo
AU  - Rodriguez E
AD  - Coordinador del Programa de Etica de Investigacion Biomedica y Psicosocial,
      Centro Interdisciplinario de Estudios en Bioetica, Universidad de Chile, Chile.
LA  - spa
GR  - R25 TW006056/TW/FIC NIH HHS/United States
PT  - Journal Article
TT  - Learning qualitative aspects of the ethics of biomedical and psychosocial
      research program of the Interdisciplinary Center for Studies on Bioethics,
      University of Chile().
PL  - Chile
TA  - Acta Bioeth
JT  - Acta bioethica
JID - 101259128
PMC - PMC3402346
MID - NIHMS373245
EDAT- 2012/07/27 06:00
MHDA- 2012/07/27 06:01
CRDT- 2012/07/27 06:00
PHST- 2012/07/27 06:00 [entrez]
PHST- 2012/07/27 06:00 [pubmed]
PHST- 2012/07/27 06:01 [medline]
AID - 10.4067/s1726-569x2012000100003 [doi]
PST - ppublish
SO  - Acta Bioeth. 2012;18(1):57-62. doi: 10.4067/s1726-569x2012000100003.


PMID- 22833440
OWN - NLM
STAT- MEDLINE
DCOM- 20130221
LR  - 20220318
IS  - 1873-4626 (Electronic)
IS  - 1091-255X (Linking)
VI  - 16
IP  - 10
DP  - 2012 Oct
TI  - Ultrasonic scalpel for gastric cancer surgery: a prospective randomized study.
PG  - 1840-6
AB  - BACKGROUND: The aim of the study was to evaluate the potential advantages of the 
      ultrasonic scalpel compared with the conventional technique in gastric cancer
      surgery. METHODS: Patients with resectable adenocarcinoma of the stomach were
      randomly assigned to ultrasonic scalpel or conventional technique. We used the
      HARMONIC FOCUS (Ethicon Endo-Surgery, Inc.) as ultrasonic scalpel. RESULTS:
      Between February 2010 and December 2010, 60 patients with resectable gastric
      cancer were enrolled into the study. Operative time was significantly shorter
      with the ultrasonic arm than with the conventional arm (median 238.5 vs. 300.5
      min; P = 0.0004). Blood loss was also significantly lower in the ultrasonic arm
      than in the conventional arm (median 351.0 vs. 569.5 ml; P = 0.016).
      Clavien-Dindo grades of postoperative complications were similar in the two
      groups. From a questionnaire survey of operators, the ultrasonic scalpel
      significantly reduced the stress of lymph node dissection (3.67 vs. 2.87; P =
      0.0006). However, in assisting surgeons, the contributions to surgery, study, and
      technical improvement of the ultrasonic group were lower than in the conventional
      group. CONCLUSIONS: This study shows that the ultrasonic scalpel is a reliable
      and safe tool for open gastric cancer surgery.
FAU - Inoue, Kentaro
AU  - Inoue K
AD  - Department of Surgery, Kansai Medical University, Shinmachi 2-3-1, Hirakata City,
      Osaka, 573-1191, Japan. inoueke@hirakata.kmu.ac.jp
FAU - Nakane, Yasushi
AU  - Nakane Y
FAU - Michiura, Taku
AU  - Michiura T
FAU - Yamada, Masanori
AU  - Yamada M
FAU - Mukaide, Hiromi
AU  - Mukaide H
FAU - Fukui, Junichi
AU  - Fukui J
FAU - Miki, Hirokazu
AU  - Miki H
FAU - Ueyama, Yosuke
AU  - Ueyama Y
FAU - Nakatake, Richi
AU  - Nakatake R
FAU - Tokuhara, Katsuji
AU  - Tokuhara K
FAU - Iwamoto, Shigeyoshi
AU  - Iwamoto S
FAU - Yanagimoto, Hiroaki
AU  - Yanagimoto H
FAU - Toyokawa, Hideyoshi
AU  - Toyokawa H
FAU - Satoi, Sohei
AU  - Satoi S
FAU - Kwon, A-Hon
AU  - Kwon AH
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20120726
PL  - United States
TA  - J Gastrointest Surg
JT  - Journal of gastrointestinal surgery : official journal of the Society for Surgery
      of the Alimentary Tract
JID - 9706084
SB  - IM
MH  - Adenocarcinoma/economics/*surgery
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Attitude of Health Personnel
MH  - Blood Loss, Surgical/prevention & control/statistics & numerical data
MH  - Dissection/economics/*instrumentation/methods
MH  - Female
MH  - Gastrectomy/economics/*instrumentation/methods
MH  - Hemostasis, Surgical/economics/*instrumentation/methods
MH  - Hospital Costs/statistics & numerical data
MH  - Humans
MH  - Intention to Treat Analysis
MH  - Japan
MH  - Lymph Node Excision/economics/*instrumentation/methods
MH  - Male
MH  - Middle Aged
MH  - Operative Time
MH  - Postoperative Complications/epidemiology
MH  - Prospective Studies
MH  - Stomach Neoplasms/economics/*surgery
MH  - Treatment Outcome
MH  - Ultrasonic Surgical Procedures/economics/*instrumentation/methods
EDAT- 2012/07/27 06:00
MHDA- 2013/02/22 06:00
CRDT- 2012/07/27 06:00
PHST- 2012/03/14 00:00 [received]
PHST- 2012/07/15 00:00 [accepted]
PHST- 2012/07/27 06:00 [entrez]
PHST- 2012/07/27 06:00 [pubmed]
PHST- 2013/02/22 06:00 [medline]
AID - 10.1007/s11605-012-1970-y [doi]
PST - ppublish
SO  - J Gastrointest Surg. 2012 Oct;16(10):1840-6. doi: 10.1007/s11605-012-1970-y. Epub
      2012 Jul 26.


PMID- 22833230
OWN - NLM
STAT- MEDLINE
DCOM- 20130703
LR  - 20211021
IS  - 1573-3599 (Electronic)
IS  - 1059-7700 (Linking)
VI  - 22
IP  - 1
DP  - 2013 Feb
TI  - Enhancing family communication about genetics: ethical and professional dilemmas.
PG  - 16-21
LID - 10.1007/s10897-012-9514-x [doi]
AB  - When a new genetic condition is diagnosed within a family, genetic counselors
      often describe a sense of responsibility towards other at risk family members to 
      be appropriately informed about their status. Successful communication of genetic
      information in families is contingent on many factors. While a small number of
      probands directly state their intention not to inform their relatives, many who
      do intend to communicate this information appear to be unsuccessful for a wide
      range of reasons and may benefit from follow up support from a genetic counselor.
      Drawing on the reciprocal-engagement model (REM) of genetic counseling practice
      we explore how enhancing family communication about genetics raises a number of
      ethical and professional challenges for counselors-and describe how we resolved
      these. A subsequent manuscript will describe the counseling framework we have
      developed to enhance family communication about genetics.
FAU - Hodgson, Jan
AU  - Hodgson J
AD  - Murdoch Childrens Research Institute, Melbourne, Victoria, Australia.
      jan.hodgson@mcri.edu.au
FAU - Gaff, Clara
AU  - Gaff C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120726
PL  - United States
TA  - J Genet Couns
JT  - Journal of genetic counseling
JID - 9206865
SB  - IM
MH  - Conflict, Psychological
MH  - *Ethics
MH  - *Ethics, Professional
MH  - *Family
MH  - *Genetic Counseling
MH  - Humans
MH  - *Professional-Family Relations
EDAT- 2012/07/27 06:00
MHDA- 2013/07/05 06:00
CRDT- 2012/07/27 06:00
PHST- 2011/12/06 00:00 [received]
PHST- 2012/06/06 00:00 [accepted]
PHST- 2012/07/27 06:00 [entrez]
PHST- 2012/07/27 06:00 [pubmed]
PHST- 2013/07/05 06:00 [medline]
AID - 10.1007/s10897-012-9514-x [doi]
PST - ppublish
SO  - J Genet Couns. 2013 Feb;22(1):16-21. doi: 10.1007/s10897-012-9514-x. Epub 2012
      Jul 26.


PMID- 22833189
OWN - NLM
STAT- MEDLINE
DCOM- 20130528
LR  - 20211021
IS  - 1543-0154 (Electronic)
IS  - 0885-8195 (Linking)
VI  - 27
IP  - 4
DP  - 2012 Dec
TI  - Ethics corner--case studies made simple: it is about the story!
PG  - 601-4
LID - 10.1007/s13187-012-0397-1 [doi]
FAU - Michalek, Arthur M
AU  - Michalek AM
AD  - Roswell Park Cancer Institute, Buffalo, NY, USA. arthur.michalek@roswellpark.org
FAU - Wicher, Camille P
AU  - Wicher CP
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Cancer Educ
JT  - Journal of cancer education : the official journal of the American Association
      for Cancer Education
JID - 8610343
SB  - IM
MH  - Education, Medical/*methods
MH  - *Ethics, Medical
MH  - Humans
MH  - Medical Records
MH  - *Problem-Based Learning
MH  - Teaching/*methods
EDAT- 2012/07/27 06:00
MHDA- 2013/05/29 06:00
CRDT- 2012/07/27 06:00
PHST- 2012/07/27 06:00 [entrez]
PHST- 2012/07/27 06:00 [pubmed]
PHST- 2013/05/29 06:00 [medline]
AID - 10.1007/s13187-012-0397-1 [doi]
PST - ppublish
SO  - J Cancer Educ. 2012 Dec;27(4):601-4. doi: 10.1007/s13187-012-0397-1.


PMID- 22832995
OWN - NLM
STAT- MEDLINE
DCOM- 20121002
LR  - 20220318
IS  - 2380-8942 (Electronic)
IS  - 2380-8942 (Linking)
VI  - 61
IP  - 3
DP  - 2012 Jul 27
TI  - Public health surveillance data: legal, policy, ethical, regulatory, and
      practical issues.
PG  - 30-4
AB  - In the United States, data systems are created by the ongoing, systematic
      collection of health, demographic, and other information through federally funded
      national surveys, vital statistics, public and private administrative and claims 
      data, regulatory data, and medical records data. Certain data systems are
      designed to support public health surveillance and have used well-defined
      protocols and standard analytic methods for assessing specific health outcomes,
      exposures, or other endpoints. However, other data systems have been designed for
      a different purpose but can be used by public health programs for surveillance.
      Several public health surveillance programs rely substantially on others' data
      systems. An example of data used for surveillance purposes but collected for
      another reason is vital statistics data. CDC's National Center for Health
      Statistics (NCHS) purchases, aggregates, and disseminates vital statistics (birth
      and death rates) that are collected at the state level. These data are used to
      understand disease burden, monitor trends, and guide public health action.
      Administrative data also can be used for surveillance purposes (e.g., Medicare
      and Social Security Disability data that have been linked to survey data to
      monitor changes in health and health-care use over time).
FAU - Bernstein, Amy B
AU  - Bernstein AB
AD  - National Center for Health Statistics, CDC, Hyattsville, MD 20782, USA.
      abernstein@cdc.gov
FAU - Sweeney, Marie Haring
AU  - Sweeney MH
CN  - Centers for Disease Control and Prevention
LA  - eng
PT  - Journal Article
PL  - United States
TA  - MMWR Suppl
JT  - MMWR supplements
JID - 101677337
SB  - IM
MH  - Centers for Disease Control and Prevention, U.S.
MH  - *Data Collection/ethics/legislation & jurisprudence/standards
MH  - *Health Policy
MH  - Health Services/statistics & numerical data
MH  - Health Status Indicators
MH  - Humans
MH  - Medicare/statistics & numerical data
MH  - Policy Making
MH  - *Population Surveillance
MH  - Public Health/*legislation & jurisprudence
MH  - Social Security/statistics & numerical data
MH  - State Government
MH  - United States
MH  - Vital Statistics
EDAT- 2012/07/27 06:00
MHDA- 2012/10/04 06:00
CRDT- 2012/07/27 06:00
PHST- 2012/07/27 06:00 [entrez]
PHST- 2012/07/27 06:00 [pubmed]
PHST- 2012/10/04 06:00 [medline]
AID - su6103a7 [pii]
PST - ppublish
SO  - MMWR Suppl. 2012 Jul 27;61(3):30-4.


PMID- 22832234
OWN - NLM
STAT- MEDLINE
DCOM- 20130308
LR  - 20191210
IS  - 1471-4973 (Electronic)
IS  - 1471-4892 (Linking)
VI  - 12
IP  - 5
DP  - 2012 Oct
TI  - Overcoming the challenges to developing new antibiotics.
PG  - 522-6
LID - 10.1016/j.coph.2012.06.010 [doi]
LID - S1471-4892(12)00108-7 [pii]
AB  - In order to meet the challenges of our current medical need to address infections
      caused by highly resistant pathogens, we propose the use of superiority trial
      designs. The proposed trials may or may not be statistically powered. All require
      extensive preclinical justification. The designs could use either historical or
      active controls. For historically controlled trials we propose two approaches for
      defining the control response rate to therapy; (1) the use of pharmacometrics
      from modern trials and (2) the use of a concurrent observational study. Designs
      for active controlled trials could be (1) standard of care+test vs. standard of
      care alone or (2) standard of care vs. test article. The second approach requires
      extensive justification to show that the test article will be of sufficient
      efficacy to allow ethical use as a single agent.
CI  - Copyright (c) 2012. Published by Elsevier Ltd.
FAU - Shlaes, David M
AU  - Shlaes DM
AD  - Anti-infectives Consulting, LLC, Stonington, CT, USA. Shlaes.david@earthlink.net
FAU - Spellberg, Brad
AU  - Spellberg B
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120724
PL  - England
TA  - Curr Opin Pharmacol
JT  - Current opinion in pharmacology
JID - 100966133
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Anti-Bacterial Agents/*therapeutic use
MH  - Drug Discovery/methods
MH  - Drug Resistance, Microbial
MH  - Health Services Needs and Demand
MH  - Humans
MH  - Infections/*drug therapy
EDAT- 2012/07/27 06:00
MHDA- 2013/03/09 06:00
CRDT- 2012/07/27 06:00
PHST- 2012/05/07 00:00 [received]
PHST- 2012/06/13 00:00 [revised]
PHST- 2012/06/27 00:00 [accepted]
PHST- 2012/07/27 06:00 [entrez]
PHST- 2012/07/27 06:00 [pubmed]
PHST- 2013/03/09 06:00 [medline]
AID - S1471-4892(12)00108-7 [pii]
AID - 10.1016/j.coph.2012.06.010 [doi]
PST - ppublish
SO  - Curr Opin Pharmacol. 2012 Oct;12(5):522-6. doi: 10.1016/j.coph.2012.06.010. Epub 
      2012 Jul 24.


PMID- 22831876
OWN - NLM
STAT- MEDLINE
DCOM- 20131127
LR  - 20151119
IS  - 1552-3918 (Electronic)
IS  - 0163-2787 (Linking)
VI  - 35
IP  - 4
DP  - 2012 Dec
TI  - Ethical aspects of clinical placebo use: what do laypeople think?
PG  - 462-76
LID - 10.1177/0163278712453993 [doi]
AB  - The study aimed to assess the attitudes of laypeople toward clinical placebo use.
      One of three imaginary stories was presented randomly in a popular news portal
      and participants (6,404 individuals) were asked to rate nine statements about it.
      In the stories, placebo therapy was used in a deceptive way. Following the
      success of the treatment, the patient was informed that the remedy contained no
      active substances. Along with self-report of attitudes, questionnaires measuring 
      dispositional optimism, somatosensory amplification and beliefs about the
      scientific validity of complementary and alternative medicine and holistic health
      were also completed. According to participants' ratings, helping patients is more
      important than avoiding deception. They did not think that they would have felt
      deceived in the described situation or that treatment would have been successful 
      in a fully informed case. Patients' attitude toward deceptive placebo use appears
      to be more pragmatic than has been previously supposed.
FAU - Koteles, Ferenc
AU  - Koteles F
AD  - Institute for Health Promotion and Sport Sciences, Eotvos Lorand University,
      Budapest, Hungary. fecuska@gmail.com
FAU - Ferentzi, Eszter
AU  - Ferentzi E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120724
PL  - United States
TA  - Eval Health Prof
JT  - Evaluation & the health professions
JID - 7805992
RN  - 0 (Placebos)
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anecdotes as Topic
MH  - Deception
MH  - Female
MH  - Humans
MH  - Hungary
MH  - Informed Consent
MH  - Male
MH  - Middle Aged
MH  - Personality Assessment
MH  - Placebo Effect
MH  - Placebos/*therapeutic use
MH  - Practice Patterns, Physicians'/*ethics
MH  - *Public Opinion
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2012/07/27 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/07/27 06:00
PHST- 2012/07/27 06:00 [entrez]
PHST- 2012/07/27 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 0163278712453993 [pii]
AID - 10.1177/0163278712453993 [doi]
PST - ppublish
SO  - Eval Health Prof. 2012 Dec;35(4):462-76. doi: 10.1177/0163278712453993. Epub 2012
      Jul 24.


PMID- 22831568
OWN - NLM
STAT- MEDLINE
DCOM- 20121210
LR  - 20211021
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 13
DP  - 2012 Jul 25
TI  - "It's for a good cause, isn't it?" - Exploring views of South African TB research
      participants on sample storage and re-use.
PG  - 19
AB  - BACKGROUND: The banking of biological samples raises a number of ethical issues
      in relation to the storage, export and re-use of samples. Whilst there is a
      growing body of literature exploring participant perspectives in North America
      and Europe, hardly any studies have been reported in Africa. This is problematic 
      in particular in light of the growing amount of research taking place in Africa, 
      and with the rise of biobanking practices also on the African continent. In order
      to investigate the perspectives of African research participants, we conducted a 
      study with research participants in a TB study in the Western Cape, South Africa.
      METHODS: Semi-structured interviews were conducted using an interview guide which
      drew on the most prominent themes expressed in current literature on sample
      storage, re-use and exportation. Interviews were conducted in Afrikaans and
      subsequently translated into English by the same interviewer. Interviews were
      transcribed verbatim and analysed qualitatively. RESULTS: The results of our
      study indicate that the majority of participants were supportive of giving
      one-time consent to the storage and re-use of their samples. The concept of
      research being for a "good cause" was a central prerequisite. Additionally, a
      significant minority requested that they be re-contacted if a future use was not 
      stipulated on the original consent. There was also considerable variation in how 
      participants understood the concept of a 'good cause', with participants
      describing three distinct categories of research, of which two were generally
      thought to constitute 'good cause' research. Research that was for-profit was
      considered to fall outside the spectrum of 'good cause' research. Participants
      displayed confidence in the abilities of the researchers to make future decisions
      regarding sample use, but seemed unaware of the role of ethics committees in
      either this process or more generally. CONCLUSIONS: Participants expressed a wide
      and complex range of views about issues of sample storage and re-use, and they
      showed a great deal of trust in researchers. Participants' willingness to have
      their samples stored and re-used is consistent with findings from existing
      studies. However, in contrast to existing literature, participants were generally
      not in favour of for-profit research. Further research needs to be done to
      explore these ideas in other communities, both in South Africa and other
      countries.
FAU - van Schalkwyk, Gerrit
AU  - van Schalkwyk G
AD  - Centre for Medical Ethics and Law, Department of Medicine, Faculty of Health
      Sciences, Stellenbosch University, Stellenbosch, South Africa.
      gvs.psych@gmail.com
FAU - de Vries, Jantina
AU  - de Vries J
FAU - Moodley, Keymanthri
AU  - Moodley K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120725
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Altruism
MH  - *Attitude
MH  - Commerce
MH  - Comprehension
MH  - Ethics Committees, Research
MH  - Female
MH  - Humans
MH  - *Informed Consent
MH  - Interviews as Topic
MH  - Male
MH  - Middle Aged
MH  - Qualitative Research
MH  - Research Design
MH  - Research Personnel
MH  - *Research Subjects
MH  - South Africa
MH  - *Specimen Handling/ethics/standards/statistics & numerical data
MH  - Surveys and Questionnaires
MH  - *Tissue Banks
MH  - *Trust
MH  - *Tuberculosis
PMC - PMC3444892
EDAT- 2012/07/27 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/07/27 06:00
PHST- 2012/01/24 00:00 [received]
PHST- 2012/07/12 00:00 [accepted]
PHST- 2012/07/27 06:00 [entrez]
PHST- 2012/07/27 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - 1472-6939-13-19 [pii]
AID - 10.1186/1472-6939-13-19 [doi]
PST - epublish
SO  - BMC Med Ethics. 2012 Jul 25;13:19. doi: 10.1186/1472-6939-13-19.


PMID- 22831482
OWN - NLM
STAT- MEDLINE
DCOM- 20121102
LR  - 20151119
IS  - 1757-6199 (Electronic)
IS  - 1757-6180 (Linking)
VI  - 4
IP  - 13
DP  - 2012 Jul
TI  - Evolving concepts and techniques for anti-doping.
PG  - 1667-80
LID - 10.4155/bio.12.146 [doi]
AB  - Technical advances are being made in many areas of biotechnology and genetics
      that are facilitating the detection of doping in sport. These improvements have
      been catalyzed by the need to counter the ever-increasing sophistication of the
      community of athletes and their retinues who are intent on the illicit use of
      physical, pharmacological and genetic tools and methods to enhance athletic
      performance, in contravention of established international ethical and legal
      standards and of international treaty. The methods described in this article
      present a partial and general picture of only some of these advances.
FAU - Friedmann, Theodore
AU  - Friedmann T
AD  - University of California, San Diego, School of Medicine, 9500 Gilman Drive, CNCB,
      Room 122, La Jolla, CA 92093-0634, USA. tfriedmann@ucsd.edu
FAU - Flenker, Ulrich
AU  - Flenker U
FAU - Georgakopoulos, Costas
AU  - Georgakopoulos C
FAU - Alsayrafi, Mohammed
AU  - Alsayrafi M
FAU - Sottas, Pierre-Edouard
AU  - Sottas PE
FAU - Williams, Stephen A
AU  - Williams SA
FAU - Gill, Rosalynn D
AU  - Gill RD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Bioanalysis
JT  - Bioanalysis
JID - 101512484
RN  - 0 (Aptamers, Nucleotide)
RN  - 0 (Biomarkers)
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Aptamers, Nucleotide/chemistry
MH  - Athletic Performance
MH  - Biological Assay/methods
MH  - Biomarkers/blood/urine
MH  - Chromatography, High Pressure Liquid/methods
MH  - Doping in Sports/legislation & jurisprudence/*prevention & control
MH  - Female
MH  - Gas Chromatography-Mass Spectrometry/methods
MH  - Genetic Enhancement/methods
MH  - Humans
MH  - International Cooperation/legislation & jurisprudence
MH  - Male
MH  - Pharmaceutical Preparations/*blood
MH  - Substance Abuse Detection/*methods/*trends
EDAT- 2012/07/27 06:00
MHDA- 2012/11/03 06:00
CRDT- 2012/07/27 06:00
PHST- 2012/07/27 06:00 [entrez]
PHST- 2012/07/27 06:00 [pubmed]
PHST- 2012/11/03 06:00 [medline]
AID - 10.4155/bio.12.146 [doi]
PST - ppublish
SO  - Bioanalysis. 2012 Jul;4(13):1667-80. doi: 10.4155/bio.12.146.


PMID- 22831471
OWN - NLM
STAT- MEDLINE
DCOM- 20121102
LR  - 20151119
IS  - 1757-6199 (Electronic)
IS  - 1757-6180 (Linking)
VI  - 4
IP  - 13
DP  - 2012 Jul
TI  - Interview: partnering with the industry: the Olympic laboratory model.
PG  - 1545-8
LID - 10.4155/bio.12.160 [doi]
AB  - David A Cowan and Campbell P Barker speak to Ryan De Vooght-Johnson at
      Bioanalysis in May 2012 about the partnership between industry and academia for
      the setup and running of the doping-control laboratory for the London 2012
      Olympic Games. David A Cowan is Director of the London 2012 anti-doping
      laboratory as well as Director of the King's College London Drug Control Centre, 
      the UK's only WADA-accredited anti-doping laboratory, and Head of the Department 
      of Forensic Science and Drug Monitoring. Cowan co-founded the Drug Control Centre
      in 1978 and became its Director in 1990. He has published extensively in the
      field of pharmaceutical analysis, especially as it relates to detecting drug
      administration in sport, and was awarded a personal chair in pharmaceutical
      toxicology in 1996. Cowan became Head of the Department of Forensic Science and
      Drug Monitoring at King's College London in 2002. He has served on a number of
      national and international committees, including the Council of Europe Working
      Party Investigating Drug Abuse in Sport that led to the first World Anti-Doping
      Convention, the Laboratory Representative on the International Olympic
      Committee's Medical Commission, and WADA's Laboratory Accreditation Subcommittee.
      He is a member of the Crippen Club for Distinguished Toxicologists. In 1998 he
      was awarded the IOC Trophy for Sport Ethics by the BOA. He was a founding member 
      of the World Association of Anti-Doping Scientists and became its first President
      serving on its Executive Board between 2001 and 2004. He was a Visiting
      Laboratory Director at the Salt Lake City Winter Olympic Games 2002, where the
      first novel erythropoiesis-stimulating protein (NESP) positive was discovered. He
      was also a senior advisory scientist at both the Turin Winter Olympic Games in
      2006 and the Beijing Olympic Games in 2008. He was also a member of the IOC
      Medical Commission for the Sydney Olympic Games in 2000 and the Vancouver Winter 
      Olympic Games in 2010. The Drug Control Centre undertook the sample analysis
      during the 2002 Manchester Commonwealth Games and Cowan was Co-Director of the
      laboratory for the Commonwealth Games in Kuala Lumpur in 1998. Cowan, who has
      directed the laboratory at King's College London for many years, was a member of 
      the bid team making the presentation to the International Olympic Committee in
      February 2005. Campbell P Barker has been leading GlaxoSmithKline's delivery of
      the London 2012 laboratory services since September 2009. Prior to that time he
      was Director of Global Strategic Projects in GlaxoSmithKline's Consumer
      Healthcare business from 2006, and from 1994 to 2006 he worked in R&D for Procter
      & Gamble. Barker holds a PhD in chemistry from the University of Durham.
FAU - Cowan, David A
AU  - Cowan DA
AD  - Department of Forensic Science & Drug Monitoring, King's College London, 150
      Stamford Street, London, SE1 9NH, UK. david.a.cowan@kcl.ac.uk
FAU - Barker, Campbell P
AU  - Barker CP
LA  - eng
PT  - Interview
PL  - England
TA  - Bioanalysis
JT  - Bioanalysis
JID - 101512484
RN  - 0 (Performance-Enhancing Substances)
RN  - 11096-26-7 (Erythropoietin)
RN  - 15UQ94PT4P (Darbepoetin alfa)
SB  - IM
MH  - Darbepoetin alfa
MH  - Doping in Sports/*legislation & jurisprudence
MH  - Drug Industry/*organization & administration
MH  - Drug and Narcotic Control/organization & administration
MH  - Erythropoietin/analogs & derivatives/analysis
MH  - Europe
MH  - Humans
MH  - International Agencies
MH  - Laboratories/*organization & administration
MH  - London
MH  - Performance-Enhancing Substances/*analysis
MH  - Public-Private Sector Partnerships/*organization & administration
MH  - Sports/legislation & jurisprudence
EDAT- 2012/07/27 06:00
MHDA- 2012/11/03 06:00
CRDT- 2012/07/27 06:00
PHST- 2012/07/27 06:00 [entrez]
PHST- 2012/07/27 06:00 [pubmed]
PHST- 2012/11/03 06:00 [medline]
AID - 10.4155/bio.12.160 [doi]
PST - ppublish
SO  - Bioanalysis. 2012 Jul;4(13):1545-8. doi: 10.4155/bio.12.160.


PMID- 22831469
OWN - NLM
STAT- MEDLINE
DCOM- 20121102
LR  - 20120726
IS  - 1757-6199 (Electronic)
IS  - 1757-6180 (Linking)
VI  - 4
IP  - 13
DP  - 2012 Jul
TI  - Ethical considerations in anti-doping analysis.
PG  - 1537-9
LID - 10.4155/bio.12.140 [doi]
FAU - Murray, Thomas H
AU  - Murray TH
LA  - eng
PT  - Editorial
PL  - England
TA  - Bioanalysis
JT  - Bioanalysis
JID - 101512484
RN  - 0 (Performance-Enhancing Substances)
SB  - IM
MH  - Athletes/*legislation & jurisprudence
MH  - Doping in Sports/*ethics/*legislation & jurisprudence
MH  - Humans
MH  - International Agencies
MH  - Performance-Enhancing Substances/*analysis
MH  - Sports/ethics/*legislation & jurisprudence
EDAT- 2012/07/27 06:00
MHDA- 2012/11/03 06:00
CRDT- 2012/07/27 06:00
PHST- 2012/07/27 06:00 [entrez]
PHST- 2012/07/27 06:00 [pubmed]
PHST- 2012/11/03 06:00 [medline]
AID - 10.4155/bio.12.140 [doi]
PST - ppublish
SO  - Bioanalysis. 2012 Jul;4(13):1537-9. doi: 10.4155/bio.12.140.


PMID- 22830508
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20120726
IS  - 1744-6171 (Electronic)
IS  - 1073-6077 (Linking)
VI  - 25
IP  - 3
DP  - 2012 Aug
TI  - Exploring the relationship among ADHD, stimulants, and substance abuse.
PG  - 113-8
LID - 10.1111/j.1744-6171.2012.00322.x [doi]
AB  - TOPIC: There is an ongoing debate among prescribers concerning the risk of
      inadvertently contributing to the initiation of substance abuse (SA) in children 
      and adolescents through the use of stimulants in the treatment of
      attention-deficit/hyperactivity disorder (ADHD). Psychiatric nurses at all levels
      of practice must be informed about this important discourse in order to provide
      accurate and timely interventions to clients and their families. PURPOSE: This
      literature review explores the current state of prescriptive stimulant use for
      ADHD and the possible links to SA. Developmental, genetic, and neuro-chemical
      theories of the disorder that may contribute to SA as well as the burden of
      comorbidity are considered. The impact of gender, cultural, legal, and ethical
      influences on diagnostic and treatment recommendations is also included. SOURCE: 
      U.S. and other English language articles were identified through PubMed and the
      Cumulated Index of Nursing and Allied Health Literature. These sources were used 
      to determine the current practice of stimulant prescription and the prevalence of
      SA as a comorbidity to other child psychiatric disorders including ADHD.
      Textbooks were consulted for information regarding relevant neurochemistry,
      genetics, and psychopharmacology. CONCLUSIONS: The authors conclude that the use 
      of stimulants is appropriate for children and adolescents with ADHD when
      opportunities for screening, family and child education, and counseling
      concerning SA are consistently integrated into the ongoing treatment regimen.
CI  - (c) 2012 Wiley Periodicals, Inc.
FAU - Nelson, Andrea
AU  - Nelson A
AD  - The University of Akron, Akron, OH, USA.
FAU - Galon, Patricia
AU  - Galon P
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120510
PL  - England
TA  - J Child Adolesc Psychiatr Nurs
JT  - Journal of child and adolescent psychiatric nursing : official publication of the
      Association of Child and Adolescent Psychiatric Nurses, Inc
JID - 9431738
RN  - 0 (Central Nervous System Stimulants)
MH  - Adolescent
MH  - *Attention Deficit Disorder with Hyperactivity/diagnosis/drug therapy/genetics
MH  - Central Nervous System Stimulants/adverse effects/*therapeutic use
MH  - Child
MH  - Comorbidity
MH  - Cultural Characteristics
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Female
MH  - Humans
MH  - Liability, Legal
MH  - Male
MH  - Medical History Taking
MH  - Psychiatric Nursing/ethics/*standards
MH  - Sex Factors
MH  - *Substance-Related Disorders/diagnosis/drug therapy/genetics
EDAT- 2012/07/27 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/27 06:00
PHST- 2012/07/27 06:00 [entrez]
PHST- 2012/07/27 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1111/j.1744-6171.2012.00322.x [doi]
PST - ppublish
SO  - J Child Adolesc Psychiatr Nurs. 2012 Aug;25(3):113-8. doi:
      10.1111/j.1744-6171.2012.00322.x. Epub 2012 May 10.


PMID- 22830450
OWN - NLM
STAT- MEDLINE
DCOM- 20130417
LR  - 20191112
IS  - 2212-3431 (Electronic)
IS  - 1872-2156 (Linking)
VI  - 6
IP  - 3
DP  - 2012 Dec
TI  - Genetics & sport: bioethical concerns.
PG  - 197-202
AB  - This paper provides an overview of the ethical issues pertaining to the use of
      genetic insights and techniques in sport. Initially, it considers a range of
      scientific findings that have stimulated debate about the ethical issues
      associated with genetics applied to sport. It also outlines some of the early
      policy responses to these discoveries from world leading sports organizations,
      along with knowledge about actual use of gene technologies in sport.
      Subsequently, it considers the challenges with distinguishing between therapeutic
      use and human enhancement within genetic science, which is a particularly
      important issue for the world of sport. Next, particular attention is given to
      the use of genetic information, which raises questions about the legitimacy and
      reliability of genetic tests, along with the potential public value of having DNA
      databanks to economize in health care. Finally, the ethics of gene transfer are
      considered, inviting questions into the values of sport and humanity. It argues
      that, while gene modification may seem conceptually similar to other forms of
      doping, the requirements upon athletes are such that new forms of enhancement
      become increasingly necessary to discover. Insofar as genetic science is able to 
      create safer, more effective techniques of human modification, then it may be an 
      appealing route through which to modify athletes to safeguard the future of elite
      sports as enterprises of human excellence.
FAU - Miah, Andy
AU  - Miah A
AD  - University of the West of Scotland. email@andymiah.net
LA  - eng
PT  - Journal Article
PL  - United Arab Emirates
TA  - Recent Pat DNA Gene Seq
JT  - Recent patents on DNA & gene sequences
JID - 101299745
SB  - IM
MH  - *Bioethical Issues
MH  - DNA Fingerprinting/methods
MH  - Doping in Sports
MH  - Genetic Enhancement/*ethics/methods
MH  - Genetic Research/ethics
MH  - Genetic Testing/*ethics
MH  - Genome, Human
MH  - Humans
MH  - Public Policy
MH  - Reproducibility of Results
MH  - Sports/*ethics/legislation & jurisprudence
EDAT- 2012/07/27 06:00
MHDA- 2013/04/18 06:00
CRDT- 2012/07/27 06:00
PHST- 2012/05/20 00:00 [received]
PHST- 2012/07/26 00:00 [revised]
PHST- 2012/07/26 00:00 [accepted]
PHST- 2012/07/27 06:00 [entrez]
PHST- 2012/07/27 06:00 [pubmed]
PHST- 2013/04/18 06:00 [medline]
AID - DNAG-EPUB-20120726-1 [pii]
AID - 10.2174/187221512802717349 [doi]
PST - ppublish
SO  - Recent Pat DNA Gene Seq. 2012 Dec;6(3):197-202. doi: 10.2174/187221512802717349.


PMID- 22830418
OWN - NLM
STAT- MEDLINE
DCOM- 20121210
LR  - 20120726
IS  - 1748-3743 (Electronic)
IS  - 1748-3735 (Linking)
VI  - 7
IP  - 3
DP  - 2012 Sep
TI  - Guest editorial: ethics matters in aged care.
PG  - 175-6
LID - 10.1111/j.1748-3743.2012.00327.x [doi]
FAU - Tuckett, Anthony G
AU  - Tuckett AG
LA  - eng
PT  - Editorial
PL  - England
TA  - Int J Older People Nurs
JT  - International journal of older people nursing
JID - 101267281
SB  - IM
MH  - Aged
MH  - *Ethics, Nursing
MH  - Geriatric Nursing/*ethics
MH  - Humans
MH  - *Public Opinion
MH  - *Social Values
EDAT- 2012/07/27 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/07/27 06:00
PHST- 2012/07/27 06:00 [entrez]
PHST- 2012/07/27 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - 10.1111/j.1748-3743.2012.00327.x [doi]
PST - ppublish
SO  - Int J Older People Nurs. 2012 Sep;7(3):175-6. doi:
      10.1111/j.1748-3743.2012.00327.x.


PMID- 22830327
OWN - NLM
STAT- MEDLINE
DCOM- 20121213
LR  - 20120726
IS  - 1466-187X (Electronic)
IS  - 0142-159X (Linking)
VI  - 34
IP  - 8
DP  - 2012
TI  - Using virtual patients to teach medical ethics, medical law and medical
      professionalism.
PG  - 674-5
LID - 10.3109/0142159X.2012.689450 [doi]
FAU - Hooper, Carwyn Rhys
AU  - Hooper CR
FAU - Jivram, Trupti
AU  - Jivram T
FAU - Law, Sarah
AU  - Law S
FAU - Michell, Alice
AU  - Michell A
FAU - Somasunderam, Arnold
AU  - Somasunderam A
LA  - eng
PT  - Letter
PL  - England
TA  - Med Teach
JT  - Medical teacher
JID - 7909593
SB  - IM
MH  - Education, Medical/methods
MH  - Ethics, Medical/*education
MH  - Humans
MH  - *Legislation, Medical
MH  - London
MH  - *Professional Competence
MH  - Teaching/*methods
MH  - *User-Computer Interface
EDAT- 2012/07/27 06:00
MHDA- 2012/12/14 06:00
CRDT- 2012/07/27 06:00
PHST- 2012/07/27 06:00 [entrez]
PHST- 2012/07/27 06:00 [pubmed]
PHST- 2012/12/14 06:00 [medline]
AID - 10.3109/0142159X.2012.689450 [doi]
PST - ppublish
SO  - Med Teach. 2012;34(8):674-5. doi: 10.3109/0142159X.2012.689450.


PMID- 22830320
OWN - NLM
STAT- MEDLINE
DCOM- 20121213
LR  - 20220310
IS  - 1466-187X (Electronic)
IS  - 0142-159X (Linking)
VI  - 34
IP  - 8
DP  - 2012
TI  - Testing the validity of a scenario-based questionnaire to assess the ethical
      sensitivity of undergraduate medical students.
PG  - 635-42
LID - 10.3109/0142159X.2012.687845 [doi]
AB  - BACKGROUND: Although medical educators acknowledge the importance of ethics in
      medical training, there are few validated instruments to assess ethical
      decision-making. One instrument is the Ethics in Health Care
      Questionnaire--version 2 (EHCQ-2). The instrument consists of 12 scenarios, each 
      posing an ethical problem in health care, and asking for a decision and
      rationale. The responses are subjectively scored in four domains: response, issue
      identification, issue sophistication, and values. GOALS: This study was intended 
      to examine the inter-rater and inter-case reliability of the AHCQ-2 and validity 
      against a national licensing examination of the EHCQ-2 in an international
      sample. METHODS: A total of 20 final year McMaster students and 45 final year
      Glasgow students participated in the study. All questionnaires were scored by
      multiple raters. Generalizability theory was used to examine inter-rater,
      inter-case and overall test reliability. Validity was assessed by comparing
      EHCQ-2 scores with scores on the Canadian written licensing examination, both
      total score and score for the ethics subsection. RESULTS: For both samples,
      reliability was quite low. Except for the first task, which is multiple choice,
      inter-rater reliability was 0.08-0.54, and inter-case reliability was 0.14-0.61. 
      Overall test reliability was 0.12-0.54. Correlation between EHCQ-2 task scores
      and the licensing examination scores ranged from 0.07 to 0.40; there was no
      evidence that the correlation was higher with the ethics subsection. CONCLUSIONS:
      The reliability and validity of the measure remains quite low, consistent with
      other measures of ethical decision-making. However, this does not limit the
      utility of the instrument as a tool to generate discussion on ethical issues in
      medicine.
FAU - Lohfeld, Lynne
AU  - Lohfeld L
AD  - McMaster University, West Hamilton, ON, Canada.
FAU - Goldie, John
AU  - Goldie J
FAU - Schwartz, Lisa
AU  - Schwartz L
FAU - Eva, Kevin
AU  - Eva K
FAU - Cotton, Phil
AU  - Cotton P
FAU - Morrison, Jillian
AU  - Morrison J
FAU - Kulamakan, Kulasegaram
AU  - Kulamakan K
FAU - Norman, Geoff
AU  - Norman G
FAU - Wood, Tim
AU  - Wood T
LA  - eng
PT  - Journal Article
PT  - Validation Study
PL  - England
TA  - Med Teach
JT  - Medical teacher
JID - 7909593
SB  - IM
MH  - Decision Making/ethics
MH  - Education, Medical, Undergraduate/*ethics
MH  - *Ethics, Medical
MH  - Humans
MH  - Observer Variation
MH  - Ontario
MH  - Reproducibility of Results
MH  - Scotland
MH  - Students, Medical/*psychology
MH  - Surveys and Questionnaires/*standards
EDAT- 2012/07/27 06:00
MHDA- 2012/12/14 06:00
CRDT- 2012/07/27 06:00
PHST- 2012/07/27 06:00 [entrez]
PHST- 2012/07/27 06:00 [pubmed]
PHST- 2012/12/14 06:00 [medline]
AID - 10.3109/0142159X.2012.687845 [doi]
PST - ppublish
SO  - Med Teach. 2012;34(8):635-42. doi: 10.3109/0142159X.2012.687845.


PMID- 22830243
OWN - NLM
STAT- MEDLINE
DCOM- 20120827
LR  - 20120726
IS  - 0131-1646 (Print)
IS  - 0131-1646 (Linking)
VI  - 38
IP  - 3
DP  - 2012 May-Jun
TI  - [Psychophysiological factors of readiness children of 6 years to education at
      school].
PG  - 48-55
AB  - Research was spent according to principles of biomedical ethics. Healthy children
      of 6 years have taken part in him (n = 120). In the course of research the
      psychophysiological factors defining readiness of children of 6 years to
      education at school are identified: "selectivity of voluntary attention" (the
      factor I); "the general working capacity" (the factor II); "a physiological
      maturity" (the factor III); "sensorimotor coordination of voluntary movement"
      (the factor IV). Factors I, II, IV correspond with activity of three blocks of
      the brain allocated with A.R. Lurija within the limits of structurally functional
      model of work of a brain as a substratum of mental activity. The carried out
      research has revealed interrelation of some indicators of readiness for education
      at school with parametres of physical working capacity.
FAU - Krivolapchuk, I A
AU  - Krivolapchuk IA
FAU - Chernova, M B
AU  - Chernova MB
LA  - rus
PT  - English Abstract
PT  - Journal Article
PL  - Russia (Federation)
TA  - Fiziol Cheloveka
JT  - Fiziologiia cheloveka
JID - 7603567
SB  - IM
MH  - Attention/*physiology
MH  - Child
MH  - *Educational Status
MH  - Female
MH  - Humans
MH  - Learning/physiology
MH  - Male
MH  - Motor Activity/physiology
MH  - Physical Endurance
MH  - *Physical Examination
MH  - Psychophysiology
MH  - Schools
EDAT- 2012/07/27 06:00
MHDA- 2012/08/28 06:00
CRDT- 2012/07/27 06:00
PHST- 2012/07/27 06:00 [entrez]
PHST- 2012/07/27 06:00 [pubmed]
PHST- 2012/08/28 06:00 [medline]
PST - ppublish
SO  - Fiziol Cheloveka. 2012 May-Jun;38(3):48-55.


PMID- 22829810
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1687-6377 (Electronic)
IS  - 1687-6369 (Linking)
VI  - 2012
DP  - 2012
TI  - DSD and Professionalism from a Multilateral View: Supplementing the Consensus
      Statement on the Basis of a Qualitative Survey.
PG  - 185787
LID - 10.1155/2012/185787 [doi]
AB  - Treatment and support of a child with DSD calls for experience and expertise in
      diagnosis, surgical techniques, understanding of psychosocial issues, and
      recognizing and accepting the significance of individual values of children,
      families, and support groups. The range of what is considered "appropriate" care 
      and treatment is still very broad and critics point at major gaps between ethical
      guidelines and current clinical practice. Based on a qualitative study with 27
      members of multidisciplinary teams and support groups, we supplement the
      professional consensus statements and current ethical guidelines with 14
      requirements from four different perspectives, to characterize more fully the
      responsible treatment and support of children and families affected by DSD.
      Overall, our findings highlight the importance of close collaborations between
      different experts and a shift from the often simplified dispute about genital
      surgeries to a more holistic perspective with a long-term management strategy,
      which should serve as a cornerstone not only for clinical practice but also for
      future research and evaluation studies.
FAU - Streuli, Jurg C
AU  - Streuli JC
AD  - Institute of Biomedical Ethics, University of Zurich, Pestalozzistrasse 24, 8032 
      Zurich, Switzerland.
FAU - Kohler, Birgit
AU  - Kohler B
FAU - Werner-Rosen, Knut
AU  - Werner-Rosen K
FAU - Mitchell, Christine
AU  - Mitchell C
LA  - eng
PT  - Journal Article
DEP - 20120709
PL  - Egypt
TA  - Adv Urol
JT  - Advances in urology
JID - 101476240
PMC - PMC3399384
EDAT- 2012/07/26 06:00
MHDA- 2012/07/26 06:01
CRDT- 2012/07/26 06:00
PHST- 2012/02/05 00:00 [received]
PHST- 2012/05/17 00:00 [accepted]
PHST- 2012/07/26 06:00 [entrez]
PHST- 2012/07/26 06:00 [pubmed]
PHST- 2012/07/26 06:01 [medline]
AID - 10.1155/2012/185787 [doi]
PST - ppublish
SO  - Adv Urol. 2012;2012:185787. doi: 10.1155/2012/185787. Epub 2012 Jul 9.


PMID- 22829681
OWN - NLM
STAT- MEDLINE
DCOM- 20121129
LR  - 20120824
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 264
IP  - 3
DP  - 2012 Sep
TI  - Working memory in patients with mild traumatic brain injury: functional MR
      imaging analysis.
PG  - 844-51
LID - 10.1148/radiol.12112154 [doi]
AB  - PURPOSE: To analyze brain activation patterns in response to tests of working
      memory after a mild traumatic brain injury (MTBI). MATERIALS AND METHODS:
      Research ethics committee approval and patient written informed consent were
      obtained. Brain activation patterns in response to n-back working memory tasks (n
      = 1, 2, 3) were assessed with functional magnetic resonance (MR) imaging in 20
      patients with MTBI within 1 month after their injury and in 18 healthy control
      subjects. In n-back working memory tasks, participants monitored a series of
      number stimuli and were to indicate when the presented number was the same as
      that presented n back previously. Nine (45%) MTBI patients underwent follow-up
      functional MR imaging studies 6 weeks later. Digit span, a memory test for how
      many numbers a person can remember in sequence, and continuous performance test
      (CPT), a test that measures a person's sustained and selective attention and
      impulsivity, were also performed before functional MR imaging studies and outside
      the imager for each participant. Clinical data were analyzed by using t and
      chi(2) tests. Within-group, between-group, and initial and follow-up differences 
      of functional MR imaging data were analyzed by using one-sample, two-sample, and 
      paired t tests, respectively. RESULTS: Groups were similar for sex (P = .75),
      years of education (P = .069), digit span (P = .37 for total score), CPT (P =
      .31, .27, and .43 for omission error, commission error, and hit reaction time,
      respectively), and accuracy of n-back working memory performance (P = .90, .11,
      and .39 for one-, two-, and three-back tasks, respectively). Brain activation
      patterns differed between MTBI patients and controls in response to increasing
      working memory loads (P < .01, uncorrected). Control subjects maintained their
      ability to increase activation in the working memory circuitry with each increase
      in working memory load. In contrast, MTBI patients were impaired in their ability
      to increase activation in working memory circuitry under both moderate and high
      working memory load conditions. However, MTBI patients did show cerebral
      plasticity, as evidenced by more activation in some areas outside and inside the 
      working memory circuitry as compared with control subjects (P < .01,
      uncorrected). In the 6-week follow-up study, compared with baseline, MTBI
      patients showed an improvement of activation in response to increasing working
      memory loads (P < .05, uncorrected). CONCLUSION: MTBI-induced differences in
      working memory functional activity were observed even though differences in
      behavioral performance between MTBI patients and controls were absent, which
      suggests that this approach may increase sensitivity to MTBI compared with
      neuropsychological evaluation alone.
CI  - (c) RSNA, 2012
FAU - Chen, Chi-Jen
AU  - Chen CJ
AD  - Department of Radiology, Taipei Medical University/Shuang Ho Hospital, New Taipei
      City, Taiwan.
FAU - Wu, Chih-Hsiung
AU  - Wu CH
FAU - Liao, Yen-Peng
AU  - Liao YP
FAU - Hsu, Hui-Ling
AU  - Hsu HL
FAU - Tseng, Ying-Chi
AU  - Tseng YC
FAU - Liu, Ho-Ling
AU  - Liu HL
FAU - Chiu, Wen-Ta
AU  - Chiu WT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120724
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adult
MH  - Brain Injuries/*physiopathology
MH  - Chi-Square Distribution
MH  - Female
MH  - Glasgow Coma Scale
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Memory, Short-Term/*physiology
MH  - Neuropsychological Tests
MH  - Prospective Studies
EDAT- 2012/07/26 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/26 06:00
PHST- 2012/07/26 06:00 [entrez]
PHST- 2012/07/26 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - radiol.12112154 [pii]
AID - 10.1148/radiol.12112154 [doi]
PST - ppublish
SO  - Radiology. 2012 Sep;264(3):844-51. doi: 10.1148/radiol.12112154. Epub 2012 Jul
      24.


PMID- 22829295
OWN - NLM
STAT- MEDLINE
DCOM- 20130627
LR  - 20211021
IS  - 1525-1497 (Electronic)
IS  - 0884-8734 (Linking)
VI  - 28
IP  - 1
DP  - 2013 Jan
TI  - The patient-centered medical home: an ethical analysis of principles and
      practice.
PG  - 141-6
LID - 10.1007/s11606-012-2170-x [doi]
AB  - The patient-centered medical home (PCMH), with its focus on patient-centered
      care, holds promise as a way to reinvigorate the primary care of patients and as 
      a necessary component of health care reform. While its tenets have been the
      subject of review, the ethical dimensions of the PCMH have not been fully
      explored. Consideration of the ethical foundations for the core principles of the
      PCMH can and should be part of the debate concerning its merits. The PCMH can
      align with the principles of medical ethics and potentially strengthen the
      patient-physician relationship and aspects of health care that patients value.
      Patient choice and these ethical considerations are central and at least as
      important as the economic and practical arguments in support of the PCMH, if not 
      more so. Further, the ethical principles that support key concepts of the PCMH
      have implications for the design and implementation of the PCMH. This paper
      explores the PCMH in light of core principles of ethics and professionalism, with
      an emphasis both on how the concept of the PCMH may reinforce core ethical
      principles of medical practice and on further implications of these principles.
FAU - Braddock, Clarence H 3rd
AU  - Braddock CH 3rd
AD  - Stanford School of Medicine, Stanford, USA.
FAU - Snyder, Lois
AU  - Snyder L
FAU - Neubauer, Richard L
AU  - Neubauer RL
FAU - Fischer, Gary S
AU  - Fischer GS
CN  - American College of Physicians Ethics, Professionalism and Human Rights Committee
      and The Society of General Internal Medicine Ethics Committee
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120725
PL  - United States
TA  - J Gen Intern Med
JT  - Journal of general internal medicine
JID - 8605834
SB  - IM
CIN - J Gen Intern Med. 2013 Jan;28(1):9-11. PMID: 23054923
MH  - Ethics, Medical
MH  - Health Care Reform/ethics/organization & administration
MH  - Humans
MH  - Patient-Centered Care/*ethics/organization & administration
MH  - Physician-Patient Relations
MH  - Primary Health Care/*ethics/organization & administration
PMC - PMC3539020
IR  - Hood VL
FIR - Hood, Virginia L
IR  - Kutty K
FIR - Kutty, Kesavan
IR  - Fins JJ
FIR - Fins, Joseph J
IR  - Berger JT
FIR - Berger, Jeffrey T
IR  - Braddock CH
FIR - Braddock, Clarence H
IR  - Calvano TP
FIR - Calvano, Tatjana P
IR  - Faber-Langendoen K
FIR - Faber-Langendoen, Kathy
IR  - Fitzgerald FT
FIR - Fitzgerald, Faith T
IR  - Gallagher TH
FIR - Gallagher, Thomas H
IR  - Goetz C
FIR - Goetz, Celine
IR  - Herrin VE
FIR - Herrin, Vincent E
IR  - Luke RG
FIR - Luke, Robert G
IR  - Mir TP
FIR - Mir, Tanveer P
IR  - Moreno A
FIR - Moreno, Alejandro
IR  - Pasha AS
FIR - Pasha, Amirala S
IR  - Ralston J Jr
FIR - Ralston, J Fred Jr
IR  - Sha MC
FIR - Sha, Michael C
IR  - Swift UM
FIR - Swift, Upasna Mini
IR  - Smart A
FIR - Smart, Alexandra
IR  - Turner BJ
FIR - Turner, Barbara J
IR  - Braddock CH
FIR - Braddock, Clarence H
IR  - Campbell EG
FIR - Campbell, Eric G
IR  - Chan EC
FIR - Chan, Evelyn C
IR  - Clever SL
FIR - Clever, Sarah L
IR  - DeCamp M
FIR - DeCamp, Matthew
IR  - Farber NJ
FIR - Farber, Neil J
IR  - Gallagher TH
FIR - Gallagher, Thomas H
IR  - Kaldjian LC
FIR - Kaldjian, Lauris C
IR  - Perez-Stable EJ
FIR - Perez-Stable, Eliseo J
IR  - Rakowski SK
FIR - Rakowski, Sonja K
IR  - Snyder L
FIR - Snyder, Lois
IR  - Torke A
FIR - Torke, Alexia
EDAT- 2012/07/26 06:00
MHDA- 2013/06/29 06:00
CRDT- 2012/07/26 06:00
PHST- 2012/02/27 00:00 [received]
PHST- 2012/06/27 00:00 [accepted]
PHST- 2012/06/14 00:00 [revised]
PHST- 2012/07/26 06:00 [entrez]
PHST- 2012/07/26 06:00 [pubmed]
PHST- 2013/06/29 06:00 [medline]
AID - 10.1007/s11606-012-2170-x [doi]
PST - ppublish
SO  - J Gen Intern Med. 2013 Jan;28(1):141-6. doi: 10.1007/s11606-012-2170-x. Epub 2012
      Jul 25.


PMID- 22829113
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130314
LR  - 20211021
IS  - 1868-310X (Print)
IS  - 1868-310X (Linking)
VI  - 4
IP  - 2
DP  - 2013 Apr
TI  - Genetics and democracy-what is the issue?
PG  - 181-8
LID - 10.1007/s12687-012-0109-x [doi]
AB  - Current developments in genetics and genomics entail a number of changes and
      challenges for society as new knowledge and technology become common in the
      clinical setting and in society at large. The relationship between genetics and
      ethics has been much discussed during the last decade, while the relationship
      between genetics and the political arena-with terms such as rights, distribution,
      expertise, participation and democracy-has been less considered. The purpose of
      this article is to demonstrate the connection between genetics and democracy. In 
      order to do this, we delineate a notion of democracy that incorporates process as
      well as substance values. On the basis of this notion of democracy and on claims 
      of democratisation in the science and technology literature, we argue for the
      importance of considering genetic issues in a democratic manner. Having
      established this connection between genetics and democracy, we discuss this
      relation in three different contexts where the relationship between genetics and 
      democracy becomes truly salient: the role of expertise, science and public
      participation, and individual responsibility and distributive justice. As
      developments within genetics and genomics advance with great speed, the
      importance and use of genetic knowledge within society can be expected to grow.
      However, this expanding societal importance of genetics might ultimately involve,
      interact with, or even confront important aspects within democratic rule and
      democratic decision-making. Moreover, we argue that the societal importance of
      genetic development makes it crucial to consider not only decision-making
      processes, but also the policy outcomes of these processes. This argument
      supports our process and substance notion of democracy, which implies that public
      participation, as a process value, must be complemented with a focus on the
      effects of policy decisions on democratic values such as distributive justice.
FAU - Hagen, Niclas
AU  - Hagen N
AD  - Department of Arts and Cultural Sciences, Ethnology, Lund University,
      Biskopsgatan 7, 223 62, Lund, Sweden, Niclas.Hagen@Kultur.lu.se.
FAU - Hedlund, Maria
AU  - Hedlund M
FAU - Lundin, Susanne
AU  - Lundin S
FAU - Mulinari, Shai
AU  - Mulinari S
FAU - Kristoffersson, Ulf
AU  - Kristoffersson U
LA  - eng
PT  - Journal Article
DEP - 20120725
PL  - Germany
TA  - J Community Genet
JT  - Journal of community genetics
JID - 101551501
PMC - PMC3666837
EDAT- 2012/07/26 06:00
MHDA- 2012/07/26 06:01
CRDT- 2012/07/26 06:00
PHST- 2012/01/29 00:00 [received]
PHST- 2012/06/21 00:00 [accepted]
PHST- 2012/07/26 06:00 [entrez]
PHST- 2012/07/26 06:00 [pubmed]
PHST- 2012/07/26 06:01 [medline]
AID - 10.1007/s12687-012-0109-x [doi]
PST - ppublish
SO  - J Community Genet. 2013 Apr;4(2):181-8. doi: 10.1007/s12687-012-0109-x. Epub 2012
      Jul 25.


PMID- 22828638
OWN - NLM
STAT- MEDLINE
DCOM- 20130211
LR  - 20161125
IS  - 1873-7064 (Electronic)
IS  - 0028-3908 (Linking)
VI  - 64
DP  - 2013 Jan
TI  - Non-pharmacological cognitive enhancement.
PG  - 529-43
LID - 10.1016/j.neuropharm.2012.07.002 [doi]
LID - S0028-3908(12)00331-0 [pii]
AB  - The term "cognitive enhancement" usually characterizes interventions in humans
      that aim to improve mental functioning beyond what is necessary to sustain or
      restore good health. While the current bioethical debate mainly concentrates on
      pharmaceuticals, according to the given characterization, cognitive enhancement
      also by non-pharmacological means has to be regarded as enhancement proper. Here 
      we summarize empirical data on approaches using nutrition, physical exercise,
      sleep, meditation, mnemonic strategies, computer training, and brain stimulation 
      for enhancing cognitive capabilities. Several of these non-pharmacological
      enhancement strategies seem to be more efficacious compared to currently
      available pharmaceuticals usually coined as cognitive enhancers. While many
      ethical arguments of the cognitive enhancement debate apply to both
      pharmacological and non-pharmacological enhancers, some of them appear in new
      light when considered on the background of non-pharmacological enhancement. This 
      article is part of a Special Issue entitled 'Cognitive Enhancers'.
CI  - Copyright (c) 2012. Published by Elsevier Ltd.
FAU - Dresler, Martin
AU  - Dresler M
AD  - Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, 80804 Munich, Germany.
      dresler@mpipsykl.mpg.de
FAU - Sandberg, Anders
AU  - Sandberg A
FAU - Ohla, Kathrin
AU  - Ohla K
FAU - Bublitz, Christoph
AU  - Bublitz C
FAU - Trenado, Carlos
AU  - Trenado C
FAU - Mroczko-Wasowicz, Aleksandra
AU  - Mroczko-Wasowicz A
FAU - Kuhn, Simone
AU  - Kuhn S
FAU - Repantis, Dimitris
AU  - Repantis D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120722
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
SB  - IM
MH  - *Aging
MH  - Animals
MH  - *Cognition
MH  - Cognitive Dysfunction/*prevention & control
MH  - Health Promotion/ethics
MH  - Humans
MH  - Self Care/ethics/*methods
EDAT- 2012/07/26 06:00
MHDA- 2013/02/12 06:00
CRDT- 2012/07/26 06:00
PHST- 2012/03/31 00:00 [received]
PHST- 2012/06/30 00:00 [revised]
PHST- 2012/07/02 00:00 [accepted]
PHST- 2012/07/26 06:00 [entrez]
PHST- 2012/07/26 06:00 [pubmed]
PHST- 2013/02/12 06:00 [medline]
AID - S0028-3908(12)00331-0 [pii]
AID - 10.1016/j.neuropharm.2012.07.002 [doi]
PST - ppublish
SO  - Neuropharmacology. 2013 Jan;64:529-43. doi: 10.1016/j.neuropharm.2012.07.002.
      Epub 2012 Jul 22.


PMID- 22828045
OWN - NLM
STAT- MEDLINE
DCOM- 20121022
LR  - 20151119
IS  - 1469-2147 (Electronic)
IS  - 0963-1801 (Linking)
VI  - 21
IP  - 4
DP  - 2012 Oct
TI  - How can empirical ethics improve medical practice?
PG  - 517-26
LID - 10.1017/S096318011200028X [doi]
FAU - Forde, Reidun
AU  - Forde R
AD  - Center for Medical Ethics in the Faculty of Medicine at the University of Oslo,
      Norway.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Camb Q Healthc Ethics
JT  - Cambridge quarterly of healthcare ethics : CQ : the international journal of
      healthcare ethics committees
JID - 9208482
SB  - IM
MH  - Attitude of Health Personnel
MH  - Delivery of Health Care/*ethics/trends
MH  - Emotions
MH  - *Empirical Research
MH  - *Ethical Theory
MH  - *Ethics Consultation
MH  - *Ethics, Medical
MH  - Health Policy
MH  - Humans
MH  - Practice Guidelines as Topic
MH  - Practice Patterns, Physicians'/*ethics/trends
MH  - Vulnerable Populations
EDAT- 2012/07/26 06:00
MHDA- 2012/10/23 06:00
CRDT- 2012/07/26 06:00
PHST- 2012/07/26 06:00 [entrez]
PHST- 2012/07/26 06:00 [pubmed]
PHST- 2012/10/23 06:00 [medline]
AID - S096318011200028X [pii]
AID - 10.1017/S096318011200028X [doi]
PST - ppublish
SO  - Camb Q Healthc Ethics. 2012 Oct;21(4):517-26. doi: 10.1017/S096318011200028X.


PMID- 22828043
OWN - NLM
STAT- MEDLINE
DCOM- 20121022
LR  - 20151119
IS  - 1469-2147 (Electronic)
IS  - 0963-1801 (Linking)
VI  - 21
IP  - 4
DP  - 2012 Oct
TI  - Empirical ethics within rapidly changing practices: a forced detoxification
      program in psychiatry as a case example.
PG  - 493-504
LID - 10.1017/S0963180112000266 [doi]
FAU - VAN Elteren, A H G
AU  - VAN Elteren AH
AD  - Department of Medical Humanities at VU University Medical Center, Amsterdam, The 
      Netherlands.
FAU - Abma, T A
AU  - Abma TA
FAU - Widdershoven, G A M
AU  - Widdershoven GA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Camb Q Healthc Ethics
JT  - Cambridge quarterly of healthcare ethics : CQ : the international journal of
      healthcare ethics committees
JID - 9208482
SB  - IM
MH  - Bioethical Issues
MH  - *Coercion
MH  - *Empirical Research
MH  - *Ethical Theory
MH  - Hospitals, Psychiatric/legislation & jurisprudence/standards
MH  - Humans
MH  - *Inactivation, Metabolic
MH  - Netherlands
MH  - Personal Autonomy
MH  - Practice Patterns, Physicians'/*ethics/legislation & jurisprudence/trends
MH  - Psychiatry/*ethics/legislation & jurisprudence/methods
MH  - Substance-Related Disorders/*therapy
EDAT- 2012/07/26 06:00
MHDA- 2012/10/23 06:00
CRDT- 2012/07/26 06:00
PHST- 2012/07/26 06:00 [entrez]
PHST- 2012/07/26 06:00 [pubmed]
PHST- 2012/10/23 06:00 [medline]
AID - S0963180112000266 [pii]
AID - 10.1017/S0963180112000266 [doi]
PST - ppublish
SO  - Camb Q Healthc Ethics. 2012 Oct;21(4):493-504. doi: 10.1017/S0963180112000266.


PMID- 22828042
OWN - NLM
STAT- MEDLINE
DCOM- 20121022
LR  - 20120725
IS  - 1469-2147 (Electronic)
IS  - 0963-1801 (Linking)
VI  - 21
IP  - 4
DP  - 2012 Oct
TI  - The normative relevance of cases: rhetoric and empirical ethics.
PG  - 481-92
LID - 10.1017/S0963180112000254 [doi]
FAU - Spranzi, Marta
AU  - Spranzi M
AD  - University of Versailles St-Quentin-en-Yvelines, France.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Camb Q Healthc Ethics
JT  - Cambridge quarterly of healthcare ethics : CQ : the international journal of
      healthcare ethics committees
JID - 9208482
SB  - IM
MH  - *Communication
MH  - *Empirical Research
MH  - *Ethical Theory
MH  - *Ethics Consultation
MH  - Ethics, Medical
MH  - Humans
EDAT- 2012/07/26 06:00
MHDA- 2012/10/23 06:00
CRDT- 2012/07/26 06:00
PHST- 2012/07/26 06:00 [entrez]
PHST- 2012/07/26 06:00 [pubmed]
PHST- 2012/10/23 06:00 [medline]
AID - S0963180112000254 [pii]
AID - 10.1017/S0963180112000254 [doi]
PST - ppublish
SO  - Camb Q Healthc Ethics. 2012 Oct;21(4):481-92. doi: 10.1017/S0963180112000254.


PMID- 22828041
OWN - NLM
STAT- MEDLINE
DCOM- 20121022
LR  - 20220408
IS  - 1469-2147 (Electronic)
IS  - 0963-1801 (Linking)
VI  - 21
IP  - 4
DP  - 2012 Oct
TI  - Toward methodological innovation in empirical ethics research.
PG  - 466-80
LID - 10.1017/S0963180112000242 [doi]
FAU - Dunn, Michael
AU  - Dunn M
AD  - Green Templeton College, at the University of Oxford, England.
FAU - Sheehan, Mark
AU  - Sheehan M
FAU - Hope, Tony
AU  - Hope T
FAU - Parker, Michael
AU  - Parker M
LA  - eng
GR  - 096527/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PL  - United States
TA  - Camb Q Healthc Ethics
JT  - Cambridge quarterly of healthcare ethics : CQ : the international journal of
      healthcare ethics committees
JID - 9208482
SB  - IM
MH  - *Empirical Research
MH  - *Ethics
MH  - Humans
MH  - *Research Design
EDAT- 2012/07/26 06:00
MHDA- 2012/10/23 06:00
CRDT- 2012/07/26 06:00
PHST- 2012/07/26 06:00 [entrez]
PHST- 2012/07/26 06:00 [pubmed]
PHST- 2012/10/23 06:00 [medline]
AID - S0963180112000242 [pii]
AID - 10.1017/S0963180112000242 [doi]
PST - ppublish
SO  - Camb Q Healthc Ethics. 2012 Oct;21(4):466-80. doi: 10.1017/S0963180112000242.


PMID- 22828039
OWN - NLM
STAT- MEDLINE
DCOM- 20121022
LR  - 20120725
IS  - 1469-2147 (Electronic)
IS  - 0963-1801 (Linking)
VI  - 21
IP  - 4
DP  - 2012 Oct
TI  - Don't solve the issues! A plea for ambiguity within empirical ethics.
PG  - 448-56
LID - 10.1017/S0963180112000229 [doi]
FAU - Molewijk, Bert
AU  - Molewijk B
AD  - Department of Medical Humanities and the EMGO+ Institute for Health and Care
      Research at VU University Medical Center, Amsterdam, the Netherlands.
FAU - Widdershoven, Guy A M
AU  - Widdershoven GA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Camb Q Healthc Ethics
JT  - Cambridge quarterly of healthcare ethics : CQ : the international journal of
      healthcare ethics committees
JID - 9208482
SB  - IM
MH  - *Bioethical Issues
MH  - Congresses as Topic
MH  - *Empirical Research
MH  - *Ethical Theory
MH  - *Ethics
MH  - Europe
MH  - Humans
MH  - Norway
MH  - Thinking
MH  - *Uncertainty
EDAT- 2012/07/26 06:00
MHDA- 2012/10/23 06:00
CRDT- 2012/07/26 06:00
PHST- 2012/07/26 06:00 [entrez]
PHST- 2012/07/26 06:00 [pubmed]
PHST- 2012/10/23 06:00 [medline]
AID - S0963180112000229 [pii]
AID - 10.1017/S0963180112000229 [doi]
PST - ppublish
SO  - Camb Q Healthc Ethics. 2012 Oct;21(4):448-56. doi: 10.1017/S0963180112000229.


PMID- 22828037
OWN - NLM
STAT- MEDLINE
DCOM- 20121022
LR  - 20120725
IS  - 1469-2147 (Electronic)
IS  - 0963-1801 (Linking)
VI  - 21
IP  - 4
DP  - 2012 Oct
TI  - What does empirical research contribute to medical ethics? A methodological
      discussion using exemplary studies.
PG  - 425-35
LID - 10.1017/S0963180112000205 [doi]
FAU - Reiter-Theil, Stella
AU  - Reiter-Theil S
AD  - University Hospital Basel / Psychiatric Hospitals of the University Basel, IBMB, 
      Switzerland.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Camb Q Healthc Ethics
JT  - Cambridge quarterly of healthcare ethics : CQ : the international journal of
      healthcare ethics committees
JID - 9208482
SB  - IM
MH  - *Empirical Research
MH  - *Ethical Theory
MH  - *Ethics, Medical
MH  - Humans
EDAT- 2012/07/26 06:00
MHDA- 2012/10/23 06:00
CRDT- 2012/07/26 06:00
PHST- 2012/07/26 06:00 [entrez]
PHST- 2012/07/26 06:00 [pubmed]
PHST- 2012/10/23 06:00 [medline]
AID - S0963180112000205 [pii]
AID - 10.1017/S0963180112000205 [doi]
PST - ppublish
SO  - Camb Q Healthc Ethics. 2012 Oct;21(4):425-35. doi: 10.1017/S0963180112000205.


PMID- 22828036
OWN - NLM
STAT- MEDLINE
DCOM- 20121022
LR  - 20120725
IS  - 1469-2147 (Electronic)
IS  - 0963-1801 (Linking)
VI  - 21
IP  - 4
DP  - 2012 Oct
TI  - Embedded ethics or fictitious facts?
PG  - 419-23
LID - 10.1017/S0963180112000199 [doi]
FAU - Solbakk, Jan Helge
AU  - Solbakk JH
LA  - eng
PT  - Editorial
PL  - United States
TA  - Camb Q Healthc Ethics
JT  - Cambridge quarterly of healthcare ethics : CQ : the international journal of
      healthcare ethics committees
JID - 9208482
SB  - IM
MH  - Empirical Research
MH  - *Ethical Theory
MH  - Ethics
MH  - *Fantasy
MH  - Humans
MH  - *Morals
EDAT- 2012/07/26 06:00
MHDA- 2012/10/23 06:00
CRDT- 2012/07/26 06:00
PHST- 2012/07/26 06:00 [entrez]
PHST- 2012/07/26 06:00 [pubmed]
PHST- 2012/10/23 06:00 [medline]
AID - S0963180112000199 [pii]
AID - 10.1017/S0963180112000199 [doi]
PST - ppublish
SO  - Camb Q Healthc Ethics. 2012 Oct;21(4):419-23. doi: 10.1017/S0963180112000199.


PMID- 22827992
OWN - NLM
STAT- MEDLINE
DCOM- 20121024
LR  - 20120725
IS  - 1938-808X (Electronic)
IS  - 1040-2446 (Linking)
VI  - 87
IP  - 8
DP  - 2012 Aug
TI  - Humanities mini-course curricula for midcareer health professionals at the Penn
      State Milton S. Hershey Medical Center.
PG  - 1132-7
LID - 10.1097/ACM.0b013e31825cee9b [doi]
AB  - The field of medical humanities has traditionally focused on medical students
      and, more recently, on premedical undergraduates. Comparatively little formal
      humanities pedagogy has been dedicated to midcareer health professionals. To
      address this lack, the Department of Humanities at the Pennsylvania State
      University College of Medicine and the Milton S. Hershey Medical Center designed 
      eight annual humanities mini-courses for faculty and staff throughout the college
      and medical center.These mini-courses fell into four categories: reading,
      reflection, and discussion; creative expression; technology; and ethics. They
      were geared toward midcareer health professionals who were seeking new
      intellectual and creative stimulation and variety in daily routine. They also
      provided humanities faculty the opportunity to devote attention to topics that
      capitalize on their professional training and that interest them
      personally.Participants indicated a high degree of satisfaction with the
      mini-courses for four principal reasons: (1) learning the tools and methodologies
      of a new discipline or domain other than biomedicine, (2) using their minds and
      training in uncustomary ways, (3) forming new alliances with colleagues (which
      served to lessen the sense of professional isolation), and (4) enjoying a respite
      from the stressful flow of the workday. Humanities faculty facilitators provided 
      more mixed responses but agreed that conducting the mini-courses had been a
      positive overall experience.Although this article provides a foundational
      framework for the development of a humanities mini-course series, the authors
      encourage others to replicate these curricula in other medical settings as an
      important step toward a robust pedagogy designed for midcareer health care
      professionals.
FAU - Myers, Kimberly R
AU  - Myers KR
AD  - Department of Humanities, Pennsylvania State University College of Medicine,
      Hershey, PA 17033, USA. krm16@psu.edu
FAU - George, Daniel R
AU  - George DR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Acad Med
JT  - Academic medicine : journal of the Association of American Medical Colleges
JID - 8904605
SB  - IM
MH  - *Curriculum
MH  - Education, Medical, Continuing/*organization & administration
MH  - Educational Measurement
MH  - Humanities/*education
MH  - Humans
MH  - Pennsylvania
MH  - Program Development
MH  - Program Evaluation
MH  - Teaching
MH  - *Writing
EDAT- 2012/07/26 06:00
MHDA- 2012/10/25 06:00
CRDT- 2012/07/26 06:00
PHST- 2012/07/26 06:00 [entrez]
PHST- 2012/07/26 06:00 [pubmed]
PHST- 2012/10/25 06:00 [medline]
AID - 10.1097/ACM.0b013e31825cee9b [doi]
AID - 00001888-201208000-00029 [pii]
PST - ppublish
SO  - Acad Med. 2012 Aug;87(8):1132-7. doi: 10.1097/ACM.0b013e31825cee9b.


PMID- 22827596
OWN - NLM
STAT- MEDLINE
DCOM- 20130417
LR  - 20191112
IS  - 2212-3431 (Electronic)
IS  - 1872-2156 (Linking)
VI  - 6
IP  - 3
DP  - 2012 Dec
TI  - Genetic determinants of athletic performance.
PG  - 175-9
AB  - An extraordinary revolution in medical research has taken place over the past
      decade, enabled by the completion of the first human genome sequence in 2001. The
      Human Genome Project (HGP) has resulted in the 6 billion letter reference human
      genome sequence and the ultra-high throughput technologies used by medical
      researchers to identify correlations between positions within the human genome
      (genotypes) and diseases or traits (phenotypes). Just as every human disease has 
      a genetic component, so too does every human trait. The vast majority of these
      diseases and traits also have an environmental component that works in
      conjunction with the body's hardwiring to produce the resultant phenotype- termed
      "complex genetic traits". A derivative of the HGP has been a deeper understanding
      not only of diseases but of normal human variability across the population,
      including aspects of athleticism. The technologies also now exist for consumers
      to cheaply gain access to variations in the genetic code that are correlated to
      traits that confer aspects of longevity, memory performance, athleticism and a
      multitude of others there-through gaining insight into propensities.
      Communication of propensity to a phenotype such as athletic performance is
      fraught with technical, legal (e.g., patents), social and ethical issues. That
      being said, the information is available, has benefit in some cases, and will be 
      utilized in the future. Given that the "genie is out of the bottle" with respect 
      to our ability to deliver this genetic information to individuals, over the past 
      decade our team has worked diligently to craft the appropriate testing and
      communication paradigms for complex traits. Here we discuss several of the major 
      risks and benefits of this type of testing for athletic performance. It is
      important to understand the limitations of genetic information in determining the
      vast majority of traits.
FAU - Stephan, Dietrich A
AU  - Stephan DA
AD  - Silicon Valley Biosystems, Navigenics, Menlo Park, CA 95026, USA.
      dstephan@svbio.com
LA  - eng
PT  - Journal Article
PL  - United Arab Emirates
TA  - Recent Pat DNA Gene Seq
JT  - Recent patents on DNA & gene sequences
JID - 101299745
SB  - IM
MH  - Athletes
MH  - Athletic Injuries/genetics
MH  - Athletic Performance/*physiology
MH  - *Genetic Predisposition to Disease
MH  - *Genetic Testing
MH  - Genetic Variation
MH  - *Genome, Human
MH  - Genotype
MH  - Humans
MH  - Odds Ratio
MH  - Phenotype
MH  - Propensity Score
MH  - Quantitative Trait, Heritable
MH  - Risk Factors
EDAT- 2012/07/26 06:00
MHDA- 2013/04/18 06:00
CRDT- 2012/07/26 06:00
PHST- 2012/07/16 00:00 [received]
PHST- 2012/07/22 00:00 [revised]
PHST- 2012/07/23 00:00 [accepted]
PHST- 2012/07/26 06:00 [entrez]
PHST- 2012/07/26 06:00 [pubmed]
PHST- 2013/04/18 06:00 [medline]
AID - DNAG-EPUB-20120724-1 [pii]
AID - 10.2174/187221512802717376 [doi]
PST - ppublish
SO  - Recent Pat DNA Gene Seq. 2012 Dec;6(3):175-9. doi: 10.2174/187221512802717376.


PMID- 22827317
OWN - NLM
STAT- MEDLINE
DCOM- 20121226
LR  - 20120725
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 26
IP  - 7
DP  - 2012 Sep
TI  - Family solidarity and informal care: the case of care for people with dementia.
PG  - 361-8
LID - 10.1111/j.1467-8519.2012.01992.x [doi]
AB  - According to Bayertz the core meaning of solidarity is the perception of mutual
      obligations between the members of a community. This definition leaves open the
      various ways solidarity is perceived by individuals in different communities and 
      how it manifests itself in a particular community. This paper explores solidarity
      as manifested in the context of families in respect of caregiving for a family
      member who has become dependent because of disease or illness. Though family
      caregiving is based on the same perception of mutual obligation as the solidarity
      that supports welfare arrangements in society, the manifestation of solidarity in
      families is different. Solidarity that underpins welfare arrangements is based on
      a perception of mutual obligation towards an anonymous dependent other and is
      enforced by the government. Solidarity in families is directed towards a concrete
      other and is based on free choice, albeit often accompanied by a strong sense of 
      personal duty. In this paper we try to distinguish between solidarity as a
      sociological concept and as a moral concept. An important moral element of
      solidarity, as expressed in families, is the need for recognition of family
      caregivers, not only of their concrete practical efforts, but also of their own
      identity as caregivers and as individuals. We illustrate this argument by
      referring to examples in the Nuffield Council on Bioethics report Dementia:
      ethical issues, about the experiences of family caregivers in dementia care and
      the importance for them of recognition of their role.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - ter Meulen, Ruud
AU  - ter Meulen R
AD  - University of Bristol-Centre for Ethics in Medicine, School of Social and
      Community Medicine, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS United
      Kingdom. R.terMeulen@bristol.ac.uk
FAU - Wright, Katharine
AU  - Wright K
LA  - eng
PT  - Journal Article
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Caregivers/*ethics
MH  - Community Health Services/ethics
MH  - Dementia/*therapy
MH  - Humans
MH  - Personal Autonomy
MH  - Personhood
MH  - Professional-Family Relations/ethics
MH  - *Social Responsibility
MH  - *Social Support
MH  - Social Welfare/*ethics
MH  - Sociology
EDAT- 2012/07/26 06:00
MHDA- 2012/12/27 06:00
CRDT- 2012/07/26 06:00
PHST- 2012/07/26 06:00 [entrez]
PHST- 2012/07/26 06:00 [pubmed]
PHST- 2012/12/27 06:00 [medline]
AID - 10.1111/j.1467-8519.2012.01992.x [doi]
PST - ppublish
SO  - Bioethics. 2012 Sep;26(7):361-8. doi: 10.1111/j.1467-8519.2012.01992.x.


PMID- 22827258
OWN - NLM
STAT- MEDLINE
DCOM- 20121210
LR  - 20220310
IS  - 1471-0528 (Electronic)
IS  - 1470-0328 (Linking)
VI  - 119
IP  - 11
DP  - 2012 Oct
TI  - Fatally flawed? A review and ethical analysis of lethal congenital malformations.
PG  - 1302-8
LID - 10.1111/j.1471-0528.2012.03450.x [doi]
AB  - Prenatally diagnosed abnormalities that are associated with death in the newborn 
      period are often referred to as 'lethal malformations'. Yet, for many of the
      commonly described lethal malformations long-term survival is possible if
      supportive interventions are provided. In this paper we analyse and review fetal 
      or congenital lethal abnormalities. The designation 'lethal' overlaps with the
      concept of 'medical futility'. The term is used for a heterogenous group of
      conditions, and hinders clear communication and counselling. We argue that the
      term should be avoided, and propose in its place a set of key questions that
      should be addressed by counselling.
CI  - (c) 2012 The Authors BJOG An International Journal of Obstetrics and Gynaecology 
      (c) 2012 RCOG.
FAU - Wilkinson, D J C
AU  - Wilkinson DJ
AD  - The Robinson Institute, Discipline of Obstetrics and Gynecology, University of
      Adelaide, North Adelaide, SA, Australia. dominic.wilkinson@adelaide.edu.au
FAU - Thiele, P
AU  - Thiele P
FAU - Watkins, A
AU  - Watkins A
FAU - De Crespigny, L
AU  - De Crespigny L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120725
PL  - England
TA  - BJOG
JT  - BJOG : an international journal of obstetrics and gynaecology
JID - 100935741
SB  - IM
CIN - BJOG. 2013 Feb;120(3):371-2. PMID: 23316904
CIN - BJOG. 2013 Feb;120(3):371. PMID: 23316905
MH  - Congenital Abnormalities/*diagnosis
MH  - Counseling
MH  - *Ethical Analysis
MH  - Female
MH  - Fetal Death
MH  - Fetus/*abnormalities
MH  - Humans
MH  - Infant Mortality
MH  - Infant, Newborn
MH  - Medical Futility
MH  - Pregnancy
MH  - Prenatal Diagnosis/*ethics
MH  - Prognosis
EDAT- 2012/07/26 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/07/26 06:00
PHST- 2012/07/26 06:00 [entrez]
PHST- 2012/07/26 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - 10.1111/j.1471-0528.2012.03450.x [doi]
PST - ppublish
SO  - BJOG. 2012 Oct;119(11):1302-8. doi: 10.1111/j.1471-0528.2012.03450.x. Epub 2012
      Jul 25.


PMID- 22827224
OWN - NLM
STAT- MEDLINE
DCOM- 20130731
LR  - 20191112
IS  - 1875-5631 (Electronic)
IS  - 1566-5232 (Linking)
VI  - 12
IP  - 5
DP  - 2012 Oct
TI  - mRNA as a versatile tool for exogenous protein expression.
PG  - 347-61
AB  - Several viral and non-viral vectors have been developed for exogenous protein
      expression in specific cells. Conventionally, this purpose is achieved through
      the use of recombinant DNA. But mainly due to the risks associated with permanent
      genetic alteration of cells, safety and ethical concerns have been raised for the
      use of DNA-based vectors in human clinical therapy. In the last years, synthetic 
      messenger RNA has emerged as powerful tool to deliver genetic information. RNA
      vectors exhibit several advantages compared to DNA and are particularly
      interesting for applications that require transient gene expression. RNA
      stability and translation efficiency can be increased by cis-acting structural
      elements in the RNA such as the 5'-cap, the poly(A)-tail, untranslated regions
      and the sequence of the coding region. Here we review recent developments in the 
      optimization of messenger RNA as vector for modulation of protein expression
      emphasizing on stability, transfection and immunogenicity. In addition, we
      summarize current pre-clinical and clinical studies using RNA-based vectors for
      immunotherapy, T cell, stem cell as well as gene therapy.
FAU - Kuhn, Andreas N
AU  - Kuhn AN
AD  - TRON (Translational Oncology at the University Medical Center of the Johannes
      Gutenberg University Mainz), Mainz, Germany.
FAU - Beibetaert, Tim
AU  - Beibetaert T
FAU - Simon, Petra
AU  - Simon P
FAU - Vallazza, Britta
AU  - Vallazza B
FAU - Buck, Janina
AU  - Buck J
FAU - Davies, Brian P
AU  - Davies BP
FAU - Tureci, Ozlem
AU  - Tureci O
FAU - Sahin, Ugur
AU  - Sahin U
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Curr Gene Ther
JT  - Current gene therapy
JID - 101125446
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Gene Expression
MH  - *Gene Transfer Techniques
MH  - Genetic Therapy
MH  - Genetic Vectors
MH  - Humans
MH  - Immunity, Innate
MH  - Protein Processing, Post-Translational
MH  - RNA Stability
MH  - RNA, Messenger/*genetics/immunology/metabolism
EDAT- 2012/07/26 06:00
MHDA- 2013/08/01 06:00
CRDT- 2012/07/26 06:00
PHST- 2012/06/29 00:00 [received]
PHST- 2012/07/11 00:00 [revised]
PHST- 2012/07/11 00:00 [accepted]
PHST- 2012/07/26 06:00 [entrez]
PHST- 2012/07/26 06:00 [pubmed]
PHST- 2013/08/01 06:00 [medline]
AID - CGT-EPUB-20120724-3 [pii]
AID - 10.2174/156652312802762536 [doi]
PST - ppublish
SO  - Curr Gene Ther. 2012 Oct;12(5):347-61. doi: 10.2174/156652312802762536.


PMID- 22827150
OWN - NLM
STAT- MEDLINE
DCOM- 20121207
LR  - 20191112
IS  - 1941-9430 (Print)
IS  - 1941-9430 (Linking)
VI  - 23
IP  - 2
DP  - 2012
TI  - Challenges and innovations in bioethics instruction for physician assistant
      programs.
PG  - 42-5
AB  - Ethics spans all of the medical specialties and is constantly evolving as new
      medical technologies develop. As PAs become involved in Institutional Ethics
      Committees (IEC) and related settings, ethics instruction becomes an increasingly
      important component of their education. Students need the tools to face ethical
      dilemmas in order to provide the best possible care to their patients across the 
      life span. Furthermore, PAs have a clear role and responsibility in end-of-life
      and palliative care. Ethics education can be most effective when incorporated
      into both the preclinical and clinical phases of instruction. There are many ways
      in which this can be accomplished so that future PAs are equipped with the
      necessary tools, skills, and information.
FAU - Ranieri, Diane
AU  - Ranieri D
AD  - Stony Brook University, New York, USA. dranieri@notes.cc.sunysb.edu
FAU - Dimitrov, Nadya
AU  - Dimitrov N
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Physician Assist Educ
JT  - The journal of physician assistant education : the official journal of the
      Physician Assistant Education Association
JID - 101298201
SB  - IM
MH  - Bioethics/*education
MH  - Ethics, Medical/*education
MH  - Humans
MH  - Palliative Care/ethics
MH  - Physician Assistants/*education
MH  - Professional Role
MH  - Terminal Care/ethics
MH  - United States
EDAT- 2012/07/26 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/07/26 06:00
PHST- 2012/07/26 06:00 [entrez]
PHST- 2012/07/26 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - 10.1097/01367895-201223020-00008 [doi]
PST - ppublish
SO  - J Physician Assist Educ. 2012;23(2):42-5. doi: 10.1097/01367895-201223020-00008.


PMID- 22826994
OWN - NLM
STAT- MEDLINE
DCOM- 20120820
LR  - 20190918
IS  - 0370-8179 (Print)
IS  - 0370-8179 (Linking)
VI  - 140
IP  - 5-6
DP  - 2012 May-Jun
TI  - [Metastatic brain tumour in pregnancy: a case report].
PG  - 365-70
AB  - INTRODUCTION: Malignant tumours of the central nervous system in pregnancy are
      rare and are most frequently diagnosed in the second part of pregnancy. Of all
      malignant tumours which may occur in pregnancy, intracranial tumours bear the
      highest risk of maternal and foetal morbidity and mortality. CASE OUTLINE: A
      29-year-old primipara was admitted to our hospital as an emergency in the
      twenty-ninth week of pregnancy due to headache, right eye sight disorders (double
      vision), nausea and vomiting. The patient had a total thyroidectomy and a
      dissection of lymph glands of the neck at the age of seven years due to papillary
      carcinoma of the thyroid glands. The clinical and sonographic test revealed
      regular foetal growth and morphology. The MRI showed expansive changes in the
      brain parenchyma corresponding to metastatic lesion with the subtentorial
      herniation of the uncus of the hippocampus by compressive effect onto the right
      cerebral peduncle of the mesencephalon. Emergent neurosurgical intervention was
      indicated. Having in mind the age at pregnancy, it was decided to perform a
      caesarean operation. Alive female child was born weighing 1,370 grams. The
      post-operative procedure was normal. The patient was transferred to the
      neurosurgery department on the first post-operative day, where she underwent
      emergent surgery. Immunohistochemistry confirmed the metastatic tumour
      originating from the primary papillary adenocarcinoma of the thyroid gland.
      CONCLUSION: Neurosurgical diseases in pregnancy simultaneously jeopardize two
      lives and represent both medical and ethical problem. Upon confirming the
      presence of intracranial malignancy in pregnancy, further procedure is very
      individual and it implies cooperation of gynaecologists, neurologists,
      neurosurgeons, oncologists, anaesthesiologists and neonatologists.
FAU - Pantovic, Sveto
AU  - Pantovic S
FAU - Sparic, Radmila
AU  - Sparic R
FAU - Mijalcic, Radovan
AU  - Mijalcic R
LA  - srp
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
PL  - Serbia
TA  - Srp Arh Celok Lek
JT  - Srpski arhiv za celokupno lekarstvo
JID - 0027440
SB  - IM
MH  - Adenocarcinoma, Papillary/*secondary/surgery
MH  - Adult
MH  - Brain Neoplasms/*secondary/surgery
MH  - Female
MH  - Humans
MH  - Pregnancy
MH  - *Pregnancy Complications, Neoplastic/surgery
MH  - Thyroid Neoplasms/*pathology/surgery
EDAT- 2012/07/26 06:00
MHDA- 2012/08/21 06:00
CRDT- 2012/07/26 06:00
PHST- 2012/07/26 06:00 [entrez]
PHST- 2012/07/26 06:00 [pubmed]
PHST- 2012/08/21 06:00 [medline]
AID - 10.2298/sarh1206365p [doi]
PST - ppublish
SO  - Srp Arh Celok Lek. 2012 May-Jun;140(5-6):365-70. doi: 10.2298/sarh1206365p.


PMID- 22826809
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2152-7806 (Electronic)
IS  - 2152-7806 (Linking)
VI  - 3
IP  - Suppl 1
DP  - 2012
TI  - Strategies for the return of behavioral surgery.
PG  - S34-9
LID - 10.4103/2152-7806.91608 [doi]
AB  - BACKGROUND: Behavioral surgery (BS) is resurging because of unmet clinical need, 
      advances in basic sciences, neuroimaging, neurostimulation, and stereotaxy.
      However, there is a danger that BS will fall unless acceptable strategies are
      adopted by BS providers. METHODS: A critical review of conditions leading to rise
      of psychosurgery (PS) and concerns resulting in its fall was conducted to learn
      lessons and safeguard BS of the future. RESULTS: PS rose and spread in 1960 like 
      wildfire without adequate preclinical and clinical studies. Hundreds of patients 
      had PS without adequate preoperative diagnosis or assessment, proper consent, and
      non-objective reporting of outcome. Furthermore, there was public opposition
      against PS because of its potential abuse to control violent behavior and
      dissidents. Advances in neurostimulation, neuroimaging, and stereotaxy, and
      emergence of treatment-resistant mental disorders led to increased interest in
      BS. Several recent studies have shown BS to be safe and effective. However,
      concerns related to strength of evidence, safety, efficacy, consent, and
      objectivity of studies have been raised. Unless clinical and regulatory
      governance structures are adopted in each jurisdiction, BS will face the same
      fate as that of PS in the past. CONCLUSION: THE FUTURE OF BS AS A SAFE AND
      EFFECTIVE THERAPY IS DEPENDENT UPON ADOPTING CLEAR MORAL ETHICAL AND GOVERNANCE
      STANDARDS ON THE FOLLOWING LINES: Patients must have failed adequate therapies;
      must be assessed by psychiatrist-led multidisciplinary teams; patients' abilities
      to give consent and diagnosis must be verified by independent authorities
      designated for this purpose by the state; and the independent authority must also
      decide whether the teams were adequately trained to perform BS.
FAU - Eljamel, Sam
AU  - Eljamel S
AD  - Centre of Neurosciences, Department of Neurosurgery, Consultant Neurological
      Surgeon, Ninewells Hospital and Medical School, Scotland, U K.
LA  - eng
PT  - Journal Article
DEP - 20120114
PL  - United States
TA  - Surg Neurol Int
JT  - Surgical neurology international
JID - 101535836
PMC - PMC3400479
OTO - NOTNLM
OT  - Capsulotomy
OT  - cingulotomy
OT  - neurostimulation
OT  - psychosurgery
OT  - stereotaxy
OT  - vagus nerve stimulation
EDAT- 2012/07/25 06:00
MHDA- 2012/07/25 06:01
CRDT- 2012/07/25 06:00
PHST- 2011/11/05 00:00 [received]
PHST- 2011/12/20 00:00 [accepted]
PHST- 2012/07/25 06:00 [entrez]
PHST- 2012/07/25 06:00 [pubmed]
PHST- 2012/07/25 06:01 [medline]
AID - 10.4103/2152-7806.91608 [doi]
AID - SNI-3-34 [pii]
PST - ppublish
SO  - Surg Neurol Int. 2012;3(Suppl 1):S34-9. doi: 10.4103/2152-7806.91608. Epub 2012
      Jan 14.


PMID- 22826292
OWN - NLM
STAT- MEDLINE
DCOM- 20130404
LR  - 20220408
IS  - 1468-2834 (Electronic)
IS  - 0002-0729 (Linking)
VI  - 41
IP  - 5
DP  - 2012 Sep
TI  - Ageing, genes, environment and epigenetics: what twin studies tell us now, and in
      the future.
PG  - 581-6
LID - 10.1093/ageing/afs097 [doi]
AB  - Compared with younger people, older people are much more variable in their organ 
      function, and these large individual differences contribute to the complexity of 
      geriatric medicine. What determines this variability? Is it due to the
      accumulation of different life experiences, or because of the variation in the
      genes we are born with, or an interaction of both? This paper reviews key
      findings from ageing twin cohorts probing these questions. Twin studies are the
      perfect natural experiment to dissect out genes and life experiences. We discuss 
      the paradox that ageing is strongly determined by heritable factors (an influence
      that often gets stronger with time), yet longevity and lifespan seem not to be so
      heritable. We then focus on the intriguing question of why DNA sequence-identical
      twins might age differently. Animal studies are increasingly showing that
      epigenetic modifications occurring in early development and adulthood, might be
      key to ageing phenomena but this is difficult to investigate longitudinally in
      human populations, due to ethical problems of intervention and long lifespan. We 
      propose that identical twin studies using new and existing cohorts may be useful 
      human models in which to investigate the interaction between the environment and 
      genetics, mediated by epigenetic modifications.
FAU - Steves, Claire Joanne
AU  - Steves CJ
AD  - Twin Research and Genetic Epidemiology, Kings College London, 1st Floor South
      Wing St Thomas' Campus Labeth Palace Road, London SE1 7EH, UK.
      claire.j.steves@kcl.ac.uk
FAU - Spector, Timothy D
AU  - Spector TD
FAU - Jackson, Stephen H D
AU  - Jackson SH
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120723
PL  - England
TA  - Age Ageing
JT  - Age and ageing
JID - 0375655
SB  - IM
MH  - Aging/*genetics/physiology
MH  - Animals
MH  - DNA Methylation/genetics
MH  - *Epigenomics
MH  - Female
MH  - *Gene-Environment Interaction
MH  - Humans
MH  - Longevity/genetics
MH  - Male
MH  - Models, Animal
MH  - Phenotype
MH  - Twin Studies as Topic/*trends
EDAT- 2012/07/25 06:00
MHDA- 2013/04/05 06:00
CRDT- 2012/07/25 06:00
PHST- 2012/07/25 06:00 [entrez]
PHST- 2012/07/25 06:00 [pubmed]
PHST- 2013/04/05 06:00 [medline]
AID - afs097 [pii]
AID - 10.1093/ageing/afs097 [doi]
PST - ppublish
SO  - Age Ageing. 2012 Sep;41(5):581-6. doi: 10.1093/ageing/afs097. Epub 2012 Jul 23.


PMID- 22825963
OWN - NLM
STAT- MEDLINE
DCOM- 20130822
LR  - 20220409
IS  - 1557-0681 (Electronic)
IS  - 1478-2189 (Linking)
VI  - 11
IP  - 1
DP  - 2013 Mar
TI  - Fatigue in ankylosing spondylitis: causes, consequences and self-management.
PG  - 39-50
LID - 10.1002/msc.1029 [doi]
AB  - OBJECTIVES: To explore the perceived causes, consequences and management of
      fatigue in ankylosing spondylitis (AS). METHODS: In this single-cohort
      qualitative study, ten participants completed a seven-day diary and participated 
      in a semi-structured interview exploring possible causes, consequences and
      self-management of fatigue. Interviews were recorded, transcribed and analysed
      using 'framework' analysis. Ethical approval was obtained. RESULTS: Three themes 
      emerged: patterns and causes, consequences and management of fatigue. While
      patients' descriptions of fatigue were similar, the patterns and perceived causes
      of fatigue varied between individuals. Fatigue impacted on social life,
      relationships and work. Two approaches to fatigue management were observed: help 
      and support from others and self-management, with four participants having sought
      medical help for fatigue. CONCLUSIONS: The study suggested that fatigue has a
      negative impact on quality of life in people with AS. Future practice should
      include a comprehensive fatigue assessment and the development of treatment
      programmes directed at enhancing self-management techniques.
CI  - Copyright (c) 2012 John Wiley & Sons, Ltd.
FAU - Farren, Wendy
AU  - Farren W
AD  - North Cumbria University Hospitals NHS Trust Carlisle, UK.
      wjfarren@btinternet.com
FAU - Goodacre, Lynne
AU  - Goodacre L
FAU - Stigant, Mark
AU  - Stigant M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120724
PL  - England
TA  - Musculoskeletal Care
JT  - Musculoskeletal care
JID - 101181344
SB  - IM
MH  - Adult
MH  - Aged
MH  - Fatigue/*complications/physiopathology/therapy
MH  - Female
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Middle Aged
MH  - Quality of Life
MH  - *Self Care
MH  - Severity of Illness Index
MH  - Spondylitis, Ankylosing/*complications/physiopathology/therapy
EDAT- 2012/07/25 06:00
MHDA- 2013/08/24 06:00
CRDT- 2012/07/25 06:00
PHST- 2012/07/25 06:00 [entrez]
PHST- 2012/07/25 06:00 [pubmed]
PHST- 2013/08/24 06:00 [medline]
AID - 10.1002/msc.1029 [doi]
PST - ppublish
SO  - Musculoskeletal Care. 2013 Mar;11(1):39-50. doi: 10.1002/msc.1029. Epub 2012 Jul 
      24.


PMID- 22825097
OWN - NLM
STAT- MEDLINE
DCOM- 20140627
LR  - 20120724
IS  - 1873-233X (Electronic)
IS  - 0029-7844 (Linking)
VI  - 120
IP  - 2 Pt 1
DP  - 2012 Aug
TI  - Reentry into clinical practice in obstetrics and gynecology.
PG  - 365-9
LID - 10.1097/AOG.0b013e318257ffba [doi]
AB  - The American College of Obstetricians and Gynecologists selected "Reentry Into
      Practice" as the subject for the 2012 Issue of the Year. Physician reentry
      programs in obstetrics and gynecology are driven by the fact that there is a
      projected physician shortage, and there are physicians who voluntarily leave
      clinical practice for a period of time. In planning formal reentry programs,
      evidence-based practice and highest regard for patient safety must be considered.
      Our department initiated a reentry fellowship program in 2010. This article
      describes the process of how we developed our program, the challenges
      encountered, and the solutions used to overcome these challenges. The formal
      instruction, evaluation, and documentation of competency are presented. Process
      improvement has been based on feedback and evaluation from the reentry fellows
      and from staff and residents. Bringing physicians back into the clinical realm
      will depend on the success of new programs implementing the guidelines
      recommended by national regulatory bodies. The guidelines recommend that the
      programs are accessible, collaborative, comprehensive, ethical, flexible,
      individualized, innovative, accountable, stable, and responsive. Our reentry
      program has been successful in helping fellows reestablish clinical practice and 
      is a way to incorporate hands-on competency-based experiences for the reentering 
      obstetrician-gynecologist (ob-gyn).
FAU - Manriquez, Maria
AU  - Manriquez M
AD  - College of Medicine, University of Arizona, and Maricopa Integrated Health
      System/District Medical Group, Phoenix, Arizona 85008, USA.
      maria_manriquez@dmgaz.org
FAU - Cookingham, Lisa Marii
AU  - Cookingham LM
FAU - Coonrod, Dean Victor
AU  - Coonrod DV
LA  - eng
PT  - Editorial
PL  - United States
TA  - Obstet Gynecol
JT  - Obstetrics and gynecology
JID - 0401101
SB  - IM
CIN - Obstet Gynecol. 2012 Aug;120(2 Pt 1):217-8. PMID: 22825076
MH  - *Education, Medical, Continuing
MH  - Gynecology/*organization & administration
MH  - Obstetrics/*organization & administration
MH  - Professional Practice/*organization & administration
EDAT- 2012/07/25 06:00
MHDA- 2014/06/28 06:00
CRDT- 2012/07/25 06:00
PHST- 2012/07/25 06:00 [entrez]
PHST- 2012/07/25 06:00 [pubmed]
PHST- 2014/06/28 06:00 [medline]
AID - 10.1097/AOG.0b013e318257ffba [doi]
AID - 00006250-201208000-00026 [pii]
PST - ppublish
SO  - Obstet Gynecol. 2012 Aug;120(2 Pt 1):365-9. doi: 10.1097/AOG.0b013e318257ffba.


PMID- 22825039
OWN - NLM
STAT- MEDLINE
DCOM- 20130201
LR  - 20120921
IS  - 1473-5628 (Electronic)
IS  - 0143-3636 (Linking)
VI  - 33
IP  - 11
DP  - 2012 Nov
TI  - Clinical evaluation of the computed tomography attenuation correction map for
      myocardial perfusion imaging: the potential for incidental pathology detection.
PG  - 1122-6
AB  - The benefits of hybrid imaging in nuclear medicine have been proven to increase
      the diagnostic accuracy and sensitivity of many procedures by localizing or
      characterizing lesions or by correcting emission data to more accurately
      represent radiopharmaceutical distribution. Single-photon emission computed
      tomography/computed tomography (SPECT/CT) has a significant role in the diagnosis
      and follow-up of ischaemic heart disease with attenuation correction data being
      obtained on an integrated CT scanner. Initially, the CT component of hybrid
      SPECT/CT systems was what could be described as low specification utilizing fixed
      output parameters. As technology has progressed, the CT component of newer
      systems has specifications that are identical to that of stand-alone diagnostic
      systems. Irrespective of the type of scanner used, the computed tomography
      attenuation correction (CTAC) for myocardial perfusion imaging produces
      low-quality, limited-range CT images of the chest that include the mediastinum,
      lung fields and surrounding soft tissues. The diagnostic potential of this data
      set is unclear; yet, examples exist whereby significant pathology can be
      identified and investigated further. Despite guidance from a number of
      professional bodies suggesting that evaluation of the resulting images for every 
      medical exposure be carried out, there is no indication as to whether this should
      include the evaluation of CTAC images. This review aims to initiate discussion by
      examining the ethical, legal, financial and practical issues (e.g. CT
      specification and image quality) surrounding the clinical evaluation of the CTAC 
      for myocardial perfusion imaging images. Reference to discussions that have taken
      place, and continue to take place, in other modalities, current European and UK
      legislations, and guidelines and research in the field will be made.
FAU - Tootell, Andrew
AU  - Tootell A
AD  - Directorate of Radiography, School of Health Sciences, The University of Salford,
      Salford, UK. a.k.tootell@salford.ac.uk
FAU - Vinjamuri, Sobhan
AU  - Vinjamuri S
FAU - Elias, Mark
AU  - Elias M
FAU - Hogg, Peter
AU  - Hogg P
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Nucl Med Commun
JT  - Nuclear medicine communications
JID - 8201017
SB  - IM
MH  - Humans
MH  - Image Processing, Computer-Assisted/*methods
MH  - *Incidental Findings
MH  - Myocardial Perfusion Imaging/*methods
MH  - Pathology/*methods
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2012/07/25 06:00
MHDA- 2013/02/05 06:00
CRDT- 2012/07/25 06:00
PHST- 2012/07/25 06:00 [entrez]
PHST- 2012/07/25 06:00 [pubmed]
PHST- 2013/02/05 06:00 [medline]
AID - 10.1097/MNM.0b013e3283571b35 [doi]
PST - ppublish
SO  - Nucl Med Commun. 2012 Nov;33(11):1122-6. doi: 10.1097/MNM.0b013e3283571b35.


PMID- 22824376
OWN - NLM
STAT- MEDLINE
DCOM- 20130107
LR  - 20211021
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 13
DP  - 2012 Jul 23
TI  - Exploring how IBCLCs manage ethical dilemmas: a qualitative study.
PG  - 18
LID - 10.1186/1472-6939-13-18 [doi]
AB  - BACKGROUND: Professional health care practice should be based on ethical
      decisions and actions. When there are competing ethical standards or principles, 
      one must choose between two or more competing options. This study explores
      ethical dilemmas experienced by International Board Certified Lactation
      Consultants. METHODS: The investigator interviewed seven International Board
      Certified Lactation Consultants and analyzed the interviews using qualitative
      research methods. RESULTS: "Staying Mother-Centred" emerged as the overall theme.
      It encompassed six categories that emerged as steps in managing ethical dilemmas:
      1) recognizing the dilemma; 2) identifying context; 3) determining choices; 4)
      strategies used; 5) results and choices the mother made; and 6) follow-up. The
      category, "Strategies used", was further analyzed and six sub-themes emerged:
      building trust; diffusing situations; empowering mothers; finding balance;
      providing information; and setting priorities. CONCLUSIONS: This study provides a
      framework for understanding how International Board Certified Lactation
      Consultants manage ethical dilemmas. Although the details of their stories
      changed, the essence of the experience remained quite constant with the
      participants making choices and acting to support the mothers. The framework
      could be the used for further research or to develop tools to support IBCLCs as
      they manage ethical dilemmas and to strengthen the profession with a firm ethics 
      foundation.
FAU - Noel-Weiss, Joy
AU  - Noel-Weiss J
AD  - School of Nursing, University of Ottawa, 451 Smyth RGN3051, Ottawa, ON, Canada
      K1H 8M5. Joy.Noel-Weiss@uottawa.ca
FAU - Cragg, Betty
AU  - Cragg B
FAU - Woodend, A Kirsten
AU  - Woodend AK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120723
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - *Breast Feeding
MH  - Canada
MH  - Certification
MH  - Choice Behavior/ethics
MH  - *Consultants
MH  - Decision Making/*ethics
MH  - Governing Board
MH  - Humans
MH  - Interviews as Topic
MH  - *Lactation
MH  - *Moral Obligations
MH  - *Mothers/psychology
MH  - Narration
MH  - *Patient-Centered Care
MH  - Power, Psychological
MH  - Qualitative Research
MH  - Trust
PMC - PMC3467169
EDAT- 2012/07/25 06:00
MHDA- 2013/01/08 06:00
CRDT- 2012/07/25 06:00
PHST- 2012/01/30 00:00 [received]
PHST- 2012/07/06 00:00 [accepted]
PHST- 2012/07/25 06:00 [entrez]
PHST- 2012/07/25 06:00 [pubmed]
PHST- 2013/01/08 06:00 [medline]
AID - 1472-6939-13-18 [pii]
AID - 10.1186/1472-6939-13-18 [doi]
PST - epublish
SO  - BMC Med Ethics. 2012 Jul 23;13:18. doi: 10.1186/1472-6939-13-18.


PMID- 22823963
OWN - NLM
STAT- MEDLINE
DCOM- 20130211
LR  - 20211021
IS  - 1545-0066 (Electronic)
IS  - 1090-3127 (Linking)
VI  - 16
IP  - 4
DP  - 2012 Oct-Dec
TI  - EMS providers and exception from informed consent research: benefits, ethics, and
      community consultation.
PG  - 425-33
LID - 10.3109/10903127.2012.702189 [doi]
AB  - BACKGROUND: As attention to, and motivation for, emergency medical services
      (EMS)-related research continues to grow, particularly exception from informed
      consent (EFIC) research, it is important to understand the thoughts, beliefs, and
      experiences of EMS providers who are actively engaged in the research. OBJECTIVE:
      We explored the attitudes, beliefs, and experiences of EMS providers regarding
      their involvement in prehospital emergency research, particularly EFIC research. 
      METHODS: Using a qualitative design, 24 participants were interviewed including
      nationally registered paramedics and Virginia-certified emergency medical
      technicians employed at Richmond Ambulance Authority, the participating EMS
      agency. At the time of our interviews, the EMS agency was involved in an EFIC
      trial. Transcribed interview data were coded and analyzed for themes. Findings
      were presented back to the EMS agency for validation. RESULTS: Overall, there
      appeared to be support for prehospital emergency research. Participants viewed
      research as necessary for the advancement of the field of EMS. Improvement in
      patient care was identified as one of the most important benefits. A number of
      ethical considerations were identified: individual risk versus public good and
      consent. The EMS providers in our study were open to working with EMS researchers
      throughout the community consultation and public disclosure process. CONCLUSION: 
      The EMS providers in our study valued research and were willing to participate in
      studies. Support for research was balanced with concerns and challenges regarding
      the role of providers in the research process.
FAU - Ripley, Elizabeth
AU  - Ripley E
AD  - Department of Internal Medicine, Division of Nephrology, Virginia Commonwealth
      University, Richmond, Virginia 23298, USA. eripley@mcvh-vcu.edu
FAU - Ramsey, Cornelia
AU  - Ramsey C
FAU - Prorock-Ernest, Amy
AU  - Prorock-Ernest A
FAU - Foco, Rebecca
AU  - Foco R
FAU - Luckett, Solomon Jr
AU  - Luckett S Jr
FAU - Ornato, Joseph P
AU  - Ornato JP
LA  - eng
GR  - RC1 NR011536/NR/NINR NIH HHS/United States
GR  - UL1 RR031990/RR/NCRR NIH HHS/United States
GR  - 5RC1NR011536-02/NR/NINR NIH HHS/United States
GR  - UL1RR031990/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20120723
PL  - England
TA  - Prehosp Emerg Care
JT  - Prehospital emergency care
JID - 9703530
SB  - IM
MH  - *Biomedical Research
MH  - Emergency Medical Services/*ethics
MH  - Emergency Medical Technicians/*ethics
MH  - *Ethics, Research
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Interviews as Topic
MH  - Male
MH  - Qualitative Research
MH  - United States
MH  - Virginia
PMC - PMC3628821
MID - NIHMS386589
EDAT- 2012/07/25 06:00
MHDA- 2013/02/12 06:00
CRDT- 2012/07/25 06:00
PHST- 2012/07/25 06:00 [entrez]
PHST- 2012/07/25 06:00 [pubmed]
PHST- 2013/02/12 06:00 [medline]
AID - 10.3109/10903127.2012.702189 [doi]
PST - ppublish
SO  - Prehosp Emerg Care. 2012 Oct-Dec;16(4):425-33. doi: 10.3109/10903127.2012.702189.
      Epub 2012 Jul 23.


PMID- 22823486
OWN - NLM
STAT- MEDLINE
DCOM- 20121130
LR  - 20211021
IS  - 1749-6632 (Electronic)
IS  - 0077-8923 (Linking)
VI  - 1265
DP  - 2012 Aug
TI  - Challenges to deep brain stimulation: a pragmatic response to ethical, fiscal,
      and regulatory concerns.
PG  - 80-90
LID - 10.1111/j.1749-6632.2012.06598.x [doi]
AB  - In response to the early success of deep brain stimulation, we offer some
      common-sense strategies to sustain the work, addressing the need to do so in a
      fiscally workable, ethically transparent, and scientifically informed manner.
      After delineating major threats, we will suggest reforms in both the legislative 
      and regulatory spheres that might remediate these challenges. We will recommend
      (1) revisions to the Bayh-Dole Act of 1980, which governs intellectual property
      exchange resulting from federally funded research; (2) revisions to the
      Association of American Medical Colleges recommendations concerning the
      management of conflicts of interest when scientists with an intellectual property
      interest participate in clinical research in tandem; (3) revisions to the Food
      and Drug Administration's pre-market approval process for new devices, including 
      a proposal for a mini-investigational device exemption; and (4) the establishment
      of a public-private partnership to build ethical and sustainable synergies
      between the scientific community, industry, and government that would foster
      discovery and innovation.
CI  - (c) 2012 New York Academy of Sciences.
FAU - Fins, Joseph J
AU  - Fins JJ
AD  - Division of Medical Ethics, Weill Cornell Medical College, New York, New York,
      USA. jjfins@med.cornell.edu
FAU - Dorfman, Gary S
AU  - Dorfman GS
FAU - Pancrazio, Joseph J
AU  - Pancrazio JJ
LA  - eng
GR  - UL1 RR024996/RR/NCRR NIH HHS/United States
GR  - UL1 TR000457/TR/NCATS NIH HHS/United States
GR  - 1UL1 RR024996/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120723
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
SB  - IM
MH  - Biomedical Research/*ethics/*legislation & jurisprudence
MH  - Conflict of Interest
MH  - Deep Brain Stimulation/*ethics/instrumentation/methods
MH  - Device Approval
MH  - Government Regulation
MH  - Humans
MH  - Intellectual Property
MH  - Public-Private Sector Partnerships
MH  - United States
MH  - United States Food and Drug Administration
PMC - PMC4030320
MID - NIHMS461658
EDAT- 2012/07/25 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/25 06:00
PHST- 2012/07/25 06:00 [entrez]
PHST- 2012/07/25 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1111/j.1749-6632.2012.06598.x [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2012 Aug;1265:80-90. doi: 10.1111/j.1749-6632.2012.06598.x.
      Epub 2012 Jul 23.


PMID- 22823138
OWN - NLM
STAT- MEDLINE
DCOM- 20130122
LR  - 20120907
IS  - 1556-3669 (Electronic)
IS  - 1530-5627 (Linking)
VI  - 18
IP  - 7
DP  - 2012 Sep
TI  - Therapy in virtual environments--clinical and ethical issues.
PG  - 558-64
LID - 10.1089/tmj.2011.0195 [doi]
AB  - BACKGROUND: As virtual reality and computer-assisted therapy strategies are
      increasingly implemented for the treatment of psychological disorders, ethical
      standards and guidelines must be considered. This study determined a set of
      ethical and legal guidelines for treatment of post-traumatic stress disorder
      (PTSD)/traumatic brain injury (TBI) in a virtual environment incorporating the
      rights of an individual who is represented by an avatar. MATERIALS AND METHODS: A
      comprehensive literature review was undertaken. An example of a case study of
      therapy in Second Life (a popular online virtual world developed by Linden Labs) 
      was described. RESULTS: Ethical and legal considerations regarding psychiatric
      treatment of PTSD/TBI in a virtual environment were examined. The following
      issues were described and discussed: authentication of providers and patients,
      informed consent, patient confidentiality, patient well-being, clinician
      competence (licensing and credentialing), training of providers, insurance for
      providers, the therapeutic environment, and emergencies. Ethical and legal
      guidelines relevant to these issues in a virtual environment were proposed.
      CONCLUSIONS: Ethical and legal issues in virtual environments are similar to
      those that occur in the in-person world. Individuals represented by an avatar
      have the rights equivalent to the individual and should be treated as such.
FAU - Yellowlees, Peter M
AU  - Yellowlees PM
AD  - Department of Psychiatry, University of California, Davis, Sacramento, California
      95817, USA. pmyellowlees@ucdavis.edu
FAU - Holloway, Kevin M
AU  - Holloway KM
FAU - Parish, Michelle Burke
AU  - Parish MB
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120723
PL  - United States
TA  - Telemed J E Health
JT  - Telemedicine journal and e-health : the official journal of the American
      Telemedicine Association
JID - 100959949
SB  - IM
MH  - Brain Injuries/*therapy
MH  - Clinical Competence
MH  - Confidentiality
MH  - Humans
MH  - Informed Consent
MH  - Patient Safety
MH  - Stress Disorders, Post-Traumatic/*therapy
MH  - Therapy, Computer-Assisted/*ethics/*legislation & jurisprudence
MH  - *User-Computer Interface
EDAT- 2012/07/25 06:00
MHDA- 2013/01/23 06:00
CRDT- 2012/07/25 06:00
PHST- 2012/07/25 06:00 [entrez]
PHST- 2012/07/25 06:00 [pubmed]
PHST- 2013/01/23 06:00 [medline]
AID - 10.1089/tmj.2011.0195 [doi]
PST - ppublish
SO  - Telemed J E Health. 2012 Sep;18(7):558-64. doi: 10.1089/tmj.2011.0195. Epub 2012 
      Jul 23.


PMID- 22823094
OWN - NLM
STAT- MEDLINE
DCOM- 20121207
LR  - 20220331
IS  - 1360-0567 (Electronic)
IS  - 0963-8237 (Linking)
VI  - 21
IP  - 4
DP  - 2012 Aug
TI  - e-Psychonauts: conducting research in online drug forum communities.
PG  - 386-94
AB  - BACKGROUND: "Legal highs" are becoming increasingly common features of the
      recreational drug market. The Internet has emerged as an important resource for
      technical and pharmacological knowledge in the absence of evidence-based
      literature, and for identifying emerging trends. Self-established drug-related
      Internet forums have emerged as particularly useful sources of information. AIMS:
      It was the aim of this study to explore the key features of drug-related Internet
      forums and the drug forum communities. METHODS: Within the framework of the
      larger Psychonaut Web Mapping project, eight English-language drug forums were
      assessed, and key features, categories, themes and attributions were identified. 
      RESULTS: The results are reported taking into account ethical issues, such as
      anonymity and confidentiality, associated with research in online communities.
      CONCLUSIONS: This study identified strong, unified and unique communities of
      recreational drug users that can provide an insight into the growing market in
      new drugs and drug compounds, and may be key components in future research, harm 
      reduction and prevention strategies.
FAU - Davey, Zoe
AU  - Davey Z
AD  - Institute of Psychiatry, King's College London, London, UK.
FAU - Schifano, Fabrizio
AU  - Schifano F
FAU - Corazza, Ornella
AU  - Corazza O
FAU - Deluca, Paolo
AU  - Deluca P
CN  - Psychonaut Web Mapping Group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Ment Health
JT  - Journal of mental health (Abingdon, England)
JID - 9212352
RN  - 0 (Illicit Drugs)
SB  - IM
MH  - Harm Reduction
MH  - Humans
MH  - *Illicit Drugs
MH  - *Information Services
MH  - *Internet
MH  - *Social Networking
MH  - Substance-Related Disorders/rehabilitation
IR  - Schifano F
FIR - Schifano, Fabrizio
IR  - Deluca P
FIR - Deluca, Paolo
IR  - Corazza O
FIR - Corazza, Ornella
IR  - Davey Z
FIR - Davey, Zoe
IR  - Fleslandc L
FIR - Fleslandc, Liv
IR  - Mannonend M
FIR - Mannonend, Miia
IR  - Majavad A
FIR - Majavad, Aino
IR  - Minellia V
FIR - Minellia, Valentina
IR  - Pagania S
FIR - Pagania, Stefania
IR  - Peltoniemid T
FIR - Peltoniemid, Teuvo
IR  - Scherbaume N
FIR - Scherbaume, Norbert
IR  - Siemanne H
FIR - Siemanne, Holger
IR  - Skutlec A
FIR - Skutlec, Arvid
IR  - Torrensb M
FIR - Torrensb, Marta
IR  - van der Kreeftf P
FIR - van der Kreeftf, Peer
IR  - di Furia L
FIR - di Furia, Lucia
IR  - Farre M
FIR - Farre, Magi
EDAT- 2012/07/25 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/07/25 06:00
PHST- 2012/07/25 06:00 [entrez]
PHST- 2012/07/25 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - 10.3109/09638237.2012.682265 [doi]
PST - ppublish
SO  - J Ment Health. 2012 Aug;21(4):386-94. doi: 10.3109/09638237.2012.682265.


PMID- 22822708
OWN - NLM
STAT- MEDLINE
DCOM- 20120820
LR  - 20120724
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 23
IP  - 2
DP  - 2012 Summer
TI  - Always on call: thoughts from a neophyte physician.
PG  - 175-6
AB  - This commentary describes a new physician who encountered a patient in crisis in 
      a nonmedical environment. It discusses professional obligations, ethical
      principles, errors committed, and reasoning behind such errors. Unusual
      circumstances, uncertainty about how to properly identify oneself as a physician,
      self-doubt, and discomfort with practicing outside one's scope of training are
      recognized as reasons behind these errors. Medical students should be reminded of
      their ethical obligation to offer emergency care within their limitations,
      instructed how to identify themselves, and guided to become competent team
      leaders. Resident doctors should continue to receive instruction as they
      internalize ethical principles and identify their scopes of practice. Practicing 
      physicians should be competent in offering basic emergency care if needed.
FAU - Scarff, Jonathan R
AU  - Scarff JR
AD  - Department of Psychiatry and Behavioral Sciences, University of Louisville School
      of Medicine, Louisville, Kentucky, USA. jonathan.scarff@louisville.edu
FAU - Musick, David W
AU  - Musick DW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
MH  - Emergency Treatment/*ethics
MH  - Ethics, Medical
MH  - Humans
MH  - Internship and Residency/ethics
MH  - *Moral Obligations
MH  - Narration
MH  - Physicians/*ethics
MH  - Seizures
MH  - Students, Medical
EDAT- 2012/07/25 06:00
MHDA- 2012/08/21 06:00
CRDT- 2012/07/25 06:00
PHST- 2012/07/25 06:00 [entrez]
PHST- 2012/07/25 06:00 [pubmed]
PHST- 2012/08/21 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2012 Summer;23(2):175-6.


PMID- 22822707
OWN - NLM
STAT- MEDLINE
DCOM- 20120820
LR  - 20181201
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 23
IP  - 2
DP  - 2012 Summer
TI  - Credentialing and certification in ethics consultation: lessons from palliative
      care.
PG  - 172-4
AB  - In response to an article by Acres and colleagues, "Credentialing the Clinical
      Ethics Consultant: An Academic Medical Center Affirms Professionalism and
      Practice:" the authors urge continued action for the credentialing and
      certification of clinical ethics consultants. They also promote a vigorous and
      engaged model for ethics consultation.
FAU - Schiedermayer, David
AU  - Schiedermayer D
AD  - Palliative Care Program at Theda Clark Medical Center, Neenah, Wisconsin, USA.
      David.Schiedermayer@thedacare.org
FAU - La Puma, John
AU  - La Puma J
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
CON - J Clin Ethics. 2012 Summer;23(2):156-64. PMID: 22822704
MH  - *Credentialing
MH  - Ethicists/*standards
MH  - *Ethics Consultation
MH  - Ethics, Clinical/*education
MH  - Humans
EDAT- 2012/07/25 06:00
MHDA- 2012/08/21 06:00
CRDT- 2012/07/25 06:00
PHST- 2012/07/25 06:00 [entrez]
PHST- 2012/07/25 06:00 [pubmed]
PHST- 2012/08/21 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2012 Summer;23(2):172-4.


PMID- 22822706
OWN - NLM
STAT- MEDLINE
DCOM- 20120820
LR  - 20181201
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 23
IP  - 2
DP  - 2012 Summer
TI  - Inside baseball and ethics consultation: a comment on "ethics been very good to
      us".
PG  - 169-71
AB  - In response to the article by Scofield, I consider the that, how, and why of
      ethics consultation, moral expertise, and the rules of the game. The question
      still to be engaged is, how does all of this work out for patients and families?
FAU - Quist, Norman
AU  - Quist N
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
CON - J Clin Ethics. 2012 Summer;23(2):165-8. PMID: 22822705
MH  - *Consultants
MH  - *Credentialing
MH  - Ethicists/*standards
MH  - *Ethics Consultation
MH  - Ethics, Clinical/*education
MH  - Humans
EDAT- 2012/07/25 06:00
MHDA- 2012/08/21 06:00
CRDT- 2012/07/25 06:00
PHST- 2012/07/25 06:00 [entrez]
PHST- 2012/07/25 06:00 [pubmed]
PHST- 2012/08/21 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2012 Summer;23(2):169-71.


PMID- 22822705
OWN - NLM
STAT- MEDLINE
DCOM- 20120820
LR  - 20120724
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 23
IP  - 2
DP  - 2012 Summer
TI  - Ethics been very good to us.
PG  - 165-8
AB  - This commentary asks whether ongoing efforts to accredit, certify, and credential
      hospital ethics consultants are nothing other than an illegal restraint on trade 
      masquerading as an effort to protect the public from harm.
FAU - Scofield, Giles R
AU  - Scofield GR
AD  - Centre for Clinical Ethics, Department of Family and Community Medicine, Faculty 
      of Medicine, University of Toronto, Toronto, Ontario. giles.scofield@utoronto.ca
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
CIN - J Clin Ethics. 2012 Summer;23(2):169-71. PMID: 22822706
MH  - *Consultants
MH  - *Credentialing/economics/trends
MH  - Education, Professional/standards
MH  - Ethicists/education/*standards
MH  - *Ethics Consultation/economics
MH  - Ethics, Clinical/*education
MH  - Humans
MH  - United States
EDAT- 2012/07/25 06:00
MHDA- 2012/08/21 06:00
CRDT- 2012/07/25 06:00
PHST- 2012/07/25 06:00 [entrez]
PHST- 2012/07/25 06:00 [pubmed]
PHST- 2012/08/21 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2012 Summer;23(2):165-8.


PMID- 22822704
OWN - NLM
STAT- MEDLINE
DCOM- 20120820
LR  - 20120724
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 23
IP  - 2
DP  - 2012 Summer
TI  - Credentialing the clinical ethics consultant: an academic medical center affirms 
      professionalism and practice.
PG  - 156-64
AB  - In response to national trends calling for increasing accountability and an
      emerging dialogue within bioethics, we describe an effort to credential clinical 
      ethicists at a major academic medical center.This effort is placed within the
      historical context of prior calls for credentialing and certification and efforts
      currently underway within organized bioethics to engage this issue.The specific
      details, and conceptual rationale, behind the NewYork-Presbyterian Hospital's
      graduated credentialing plan are shared as is their evolution and ratification
      within the context of institutional policy. While other programs will design
      their credentialing schema consistent with their local context and demographics, 
      the description of one such effort is offered to be instructive to others who
      want to bring additional standardization to the assessment of the readiness and
      credentials of those who will engage in the practice of clinical ethics case
      consultation.
FAU - Acres, Cathleen A
AU  - Acres CA
AD  - Division of Medical Ethics at Weill Cornell Medical College, in NewYork, NY, USA.
FAU - Prager, Kenneth
AU  - Prager K
FAU - Hardart, George E
AU  - Hardart GE
FAU - Fins, Joseph J
AU  - Fins JJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
CIN - J Clin Ethics. 2012 Summer;23(2):172-4. PMID: 22822707
MH  - Advisory Committees
MH  - *Credentialing/organization & administration/standards/trends
MH  - Education, Professional/standards
MH  - Ethicists/education/*standards
MH  - Ethics Committees
MH  - *Ethics Consultation
MH  - Ethics, Clinical/*education
MH  - Hospitals, Religious
MH  - Humans
MH  - New York
EDAT- 2012/07/25 06:00
MHDA- 2012/08/21 06:00
CRDT- 2012/07/25 06:00
PHST- 2012/07/25 06:00 [entrez]
PHST- 2012/07/25 06:00 [pubmed]
PHST- 2012/08/21 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2012 Summer;23(2):156-64.


PMID- 22822703
OWN - NLM
STAT- MEDLINE
DCOM- 20120820
LR  - 20181201
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 23
IP  - 2
DP  - 2012 Summer
TI  - Truly intensive clinical ethics immersion at the Washington Hospital Center.
PG  - 152-5
AB  - Opportunities for practical, hospital-based training in those skills demanded by 
      clinical ethics consultation (CEC) have been limited. Given the number of
      individuals who provide part-time CEC, greater access to condensed, practical
      training such as the clinical ethics immersion course offered by the Washington
      Hospital Center, is necessary. Two participants in the initial cohort evaluate
      their CE training at a busy, urban referral center, exploring prior expectations,
      perceptions of its utility and suggestions for improvement. Such training will
      prove valuable not only for bioethicists who lack practical CEC experience "at
      the bedside" but also for ethics consultants whose ethics services have a low
      consult volume who wish to sharpen their skills.
FAU - Church, Christopher L
AU  - Church CL
AD  - Division of General and Health Studies, Baptist College of Health Sciences,
      Memphis, Tennessee, USA. christopher.church@bchs.edu
FAU - Arawi, Thalia
AU  - Arawi T
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
CON - J Clin Ethics. 2012 Summer;23(2):139-46. PMID: 22822701
MH  - Ethics, Clinical/*education
MH  - Female
MH  - Health Personnel/*education
MH  - Humans
MH  - Inservice Training/*methods
MH  - Male
MH  - Teaching/*methods
EDAT- 2012/07/25 06:00
MHDA- 2012/08/21 06:00
CRDT- 2012/07/25 06:00
PHST- 2012/07/25 06:00 [entrez]
PHST- 2012/07/25 06:00 [pubmed]
PHST- 2012/08/21 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2012 Summer;23(2):152-5.


PMID- 22822702
OWN - NLM
STAT- MEDLINE
DCOM- 20120820
LR  - 20120724
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 23
IP  - 2
DP  - 2012 Summer
TI  - Training in clinical ethics consultation: the Washington Hospital Center course.
PG  - 147-51
AB  - How can one be trained to enter the evolving field of clinical ethics
      consultation? The classroom is not the proper place to teach clinical ethics
      consultation; it is best done in a clinical setting. The author maps the elements
      that might be included in an apprenticeship, and sets out propositions for debate
      regarding the training needed for clinical ethics consultants and directors of
      clinical ethics consultation services. I was invited to be an observer of the
      first Intensive Course in Clinical Ethics at the Washington Hospital Center
      (WHC). I had no input into the planning. Having been present at a meeting of the 
      Clinical Ethics Consultation Affinity Group of the American Society of Bioethics 
      and Humanities (ASBH) when the issue of a lack of training programs was
      discussed, I was acutely aware of the need. Knowing how popular the various
      four-day intensive courses in bioethics have been, held at Georgetown University 
      first, and then in Seattle and locations in the Midwest, it seemed time to have a
      four-day intensive course that was devoted to clinical ethics. The differences
      between bioethics and clinical ethics is substantial and largely unappreciated by
      those in bioethics. So when the WHC team agreed to take on the task of offering
      an intensive in clinical ethics, it was an important step for the field.
FAU - Spike, Jeffrey P
AU  - Spike JP
AD  - McGovern Center for Humanities and Ethics, University of Texas, Houston, USA.
      Jeffrey.P.Spike@uth.tmc.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
MH  - Adult
MH  - Curriculum
MH  - District of Columbia
MH  - Ethics Committees, Clinical
MH  - *Ethics Consultation
MH  - Ethics, Clinical/*education
MH  - Female
MH  - Health Personnel/education
MH  - Humans
MH  - Inservice Training/*methods/organization & administration
MH  - Male
MH  - Middle Aged
MH  - Teaching/*methods/organization & administration
MH  - Time Factors
EDAT- 2012/07/25 06:00
MHDA- 2012/08/21 06:00
CRDT- 2012/07/25 06:00
PHST- 2012/07/25 06:00 [entrez]
PHST- 2012/07/25 06:00 [pubmed]
PHST- 2012/08/21 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2012 Summer;23(2):147-51.


PMID- 22822701
OWN - NLM
STAT- MEDLINE
DCOM- 20120820
LR  - 20120724
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 23
IP  - 2
DP  - 2012 Summer
TI  - Training in clinical ethics: launching the clinical ethics immersion course at
      the Center for Ethics at the Washington Hospital Center.
PG  - 139-46
AB  - In May 2011, the clinical ethics group of the Center for Ethics at Washington
      Hospital Center launched a 40-hour, three and one-half day Clinical Ethics
      Immersion Course. Created to address gaps in training in the practice of clinical
      ethics, the course is for those who now practice clinical ethics and for those
      who teach bioethics but who do not, or who rarely, have the opportunity to be in 
      a clinical setting. "Immersion" refers to a high-intensity clinical ethics
      experience in a busy, urban, acute care hospital. During the Immersion Course,
      participants join clinical ethicists on working rounds in intensive care units
      and trauma service. Participants engage in a videotaped role-play conversation
      with an actor. Each simulated session reflects a practical, realistic clinical
      ethics case consultation scenario. Participants also review patients' charts, and
      have small group discussions on selected clinical ethics topics. As ethics
      consultation requests come into the center, Immersion Course participants
      accompany clinical ethicists on consultations. Specific to this pilot, because
      participants' evaluations and course faculty impressions were positive, the
      Center for Ethics will conduct the course twice each year. We look forward to
      improving the pilot and establishing the Immersion Course as one step towards
      addressing the gap in training opportunities in clinical ethics.
FAU - Mokwunye, Nneka O
AU  - Mokwunye NO
AD  - Center for Ethics, Department of Spiritual Care at Washington Hospital Center,
      MedStar Health, Washington, DC, USA. Nneka.O.Mokwunye@Medstar.net.
FAU - DeRenzo, Evan G
AU  - DeRenzo EG
FAU - Brown, Virginia A
AU  - Brown VA
FAU - Lynch, John J
AU  - Lynch JJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
CIN - J Clin Ethics. 2012 Summer;23(2):152-5. PMID: 22822703
MH  - Adult
MH  - Curriculum
MH  - District of Columbia
MH  - Ethics Committees, Clinical
MH  - Ethics Consultation
MH  - Ethics, Clinical/*education
MH  - Female
MH  - Health Personnel/*education
MH  - Hospitals, General
MH  - Hospitals, Private
MH  - Humans
MH  - Inservice Training/*methods/organization & administration
MH  - Male
MH  - Middle Aged
MH  - Negotiating
MH  - Role Playing
MH  - Teaching/*methods/organization & administration
MH  - Videotape Recording
EDAT- 2012/07/25 06:00
MHDA- 2012/08/21 06:00
CRDT- 2012/07/25 06:00
PHST- 2012/07/25 06:00 [entrez]
PHST- 2012/07/25 06:00 [pubmed]
PHST- 2012/08/21 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2012 Summer;23(2):139-46.


PMID- 22822700
OWN - NLM
STAT- MEDLINE
DCOM- 20120820
LR  - 20151119
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 23
IP  - 2
DP  - 2012 Summer
TI  - The effect of completing a surrogacy information and decision-making tool upon
      admission to an intensive care unit on length of stay and charges.
PG  - 129-38
AB  - BACKGROUND AND PURPOSE: Many critically ill patients in intensive care units
      (ICUs) are unable to communicate their wishes about goals of care, particularly
      about the use of life-sustaining treatments. Surrogates and clinicians struggle
      with medical decisions because of a lack of clarity regarding patients'
      preferences, leading to prolonged hospitalizations and increased costs. This
      project focused on the development and implementation of a tool to facilitate a
      better communication process by (1) assuring the early identification of a
      surrogate if indicated on admission and (2) clarifying the decision-making
      standards that the surrogate was to use when participating in decision making.
      Before introducing the tool into the admissions routine, the staff were educated 
      about its use and value to the decision-making process. PROJECT AND METHODS: The 
      study was to determine if early use of a simple method of identifying a patient's
      surrogate and treatment preferences might impact length of stay (LOS) and total
      hospital charges. A pre- and post-intervention study design was used. Nurses
      completed the surrogacy information tool for all patients upon admission to the
      neuroscience ICU. Subjects (total N = 203) were critically ill patients who had
      been on a mechanical ventilator for 96 hours or longer, or in the ICU for seven
      days or longer.The project included staff education on biomedical ethics,
      critical communication skills, early identification of families and staff in
      crisis, and use of a simple tool to document patients' surrogates and previously 
      expressed care wishes. Data on hospital LOS and hospital charges were collected
      through a retrospective review of medical records for similar four-month time
      frames pre- and post-implementation of the assessment tool. RESULTS: Significant 
      differences were found between pre- and post-groups in terms of hospital LOS (F =
      6.39, p = .01) and total hospital charges (F = 7.03, p = .009). CONCLUSIONS:
      Project findings indicate that the use of a simple admission assessment tool,
      supported by staff education about its completion, use, and available resources, 
      can decrease LOS and lower total hospital charges. The reasons for the difference
      between the pre- and post-intervention groups remain unclear. Further research is
      needed to evaluate if the quality of communications between patients, their
      legally authorized representatives, and clinicians--as suggested in the
      literature--may have played a role in decreasing LOS and total hospital charges.
FAU - Hatler, Carol W
AU  - Hatler CW
AD  - St. Joseph's Hospital and Medical Center in Phoenix, Arizona, USA.
      Carol.Hatler@DignityHealth.org
FAU - Grove, Charlene
AU  - Grove C
FAU - Strickland, Stephanie
AU  - Strickland S
FAU - Barron, Starr
AU  - Barron S
FAU - White, Bruce D
AU  - White BD
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
MH  - Adult
MH  - Aged
MH  - Arizona
MH  - Bioethical Issues
MH  - Bioethics/education
MH  - Clinical Competence
MH  - Communication
MH  - Critical Care/economics
MH  - Critical Illness/*economics/therapy
MH  - Decision Making/ethics
MH  - Female
MH  - *Hospital Charges/statistics & numerical data
MH  - Humans
MH  - *Inservice Training
MH  - Intensive Care Units/*economics
MH  - Length of Stay/*economics
MH  - Male
MH  - Medical Records
MH  - Middle Aged
MH  - Neurosurgery
MH  - Nursing Staff, Hospital/*education
MH  - *Proxy
MH  - Respiration, Artificial/economics
MH  - Retrospective Studies
MH  - Surveys and Questionnaires
EDAT- 2012/07/25 06:00
MHDA- 2012/08/21 06:00
CRDT- 2012/07/25 06:00
PHST- 2012/07/25 06:00 [entrez]
PHST- 2012/07/25 06:00 [pubmed]
PHST- 2012/08/21 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2012 Summer;23(2):129-38.


PMID- 22822699
OWN - NLM
STAT- MEDLINE
DCOM- 20120820
LR  - 20181201
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 23
IP  - 2
DP  - 2012 Summer
TI  - Different standards are not double standards: all elective surgical patients are 
      not alike.
PG  - 118-28
AB  - Testa and colleagues argue that evaluation for suitability for living donor
      surgery is rooted in paternalism in contrast with the evaluation for most
      operative interventions, which is rooted in the autonomy of patients. We examine 
      two key ethical concepts that Testa and colleagues use: paternalism and autonomy,
      and two related ethical concepts: moral agency and shared decision making. We
      show that by moving the conversation from paternalism, negative autonomy, and
      informed consent to moral agency, relational autonomy, and shared decision
      making, one better understands why the arguments given by Testa and colleagues
      fail. We argue (1) why the hurdles that one must overcome to become a living
      donor are appropriate; and (2) that the similarities between living donor
      transplant surgery and cosmetic plastic surgery that the authors describe are
      inaccurate. Finally, we consider the recommendation to treat plastic surgery
      patients and living donors more similarly. We argue that any change should not be
      in the direction of becoming less protective of living donors, but more
      protective of cosmetic plastic surgery candidates.
FAU - Ross, Lainie Friedman
AU  - Ross LF
AD  - Department of Pediatrics, MacLean Center for Clinical Medical Ethics, University 
      of Chicago, USA. Lross@uchicago.edu
FAU - Glannon, Walter
AU  - Glannon W
FAU - Gottlieb, Lawrence J
AU  - Gottlieb LJ
FAU - Thistlethwaite, J Richard Jr
AU  - Thistlethwaite JR Jr
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
CON - J Clin Ethics. 2012 Summer;23(2):110-7. PMID: 22822698
CIN - J Clin Ethics. 2012 Summer;23(2):99-109. PMID: 22822697
CIN - J Clin Ethics. 2012 Fall;23(3):288. PMID: 23256409
MH  - *Coercion
MH  - Humans
MH  - *Living Donors
MH  - *Moral Obligations
MH  - Organ Transplantation/*ethics
MH  - *Personal Autonomy
MH  - Physician-Patient Relations/*ethics
MH  - Surgery, Plastic/*ethics
MH  - *Tissue and Organ Procurement
EDAT- 2012/07/25 06:00
MHDA- 2012/08/21 06:00
CRDT- 2012/07/25 06:00
PHST- 2012/07/25 06:00 [entrez]
PHST- 2012/07/25 06:00 [pubmed]
PHST- 2012/08/21 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2012 Summer;23(2):118-28.


PMID- 22822698
OWN - NLM
STAT- MEDLINE
DCOM- 20120820
LR  - 20121221
IS  - 1046-7890 (Print)
IS  - 1046-7890 (Linking)
VI  - 23
IP  - 2
DP  - 2012 Summer
TI  - Living donation and cosmetic surgery: a double standard in medical ethics?
PG  - 110-7
AB  - The commitment of transplant physicians to protect the physical and psychological
      health of potential donors is fundamental to the process of living donor organ
      transplantation. It is appropriate that strict regulations to govern an
      individual's decision to donate have been developed. Some may argue that
      adherence to such regulations creates a doctor-patient relationship that is
      rooted in paternalism, which is in drastic contrast with a doctor-patient
      relationship that is rooted in patients' autonomy, characteristic of most other
      operative interventions. In this article we analyze the similarities between
      cosmetic plastic surgery and living donor surgery as examples of surgeries
      governed by different ethical principles. It is interesting that, while the
      prevailing ethical approach in living donor surgery is based on paternalism, the 
      ethical principle guiding cosmetic surgery is respect for patients' autonomy. The
      purpose of this article is not to criticize either practice, but to suggest that,
      given the similarities between the two procedures, both operative interventions
      should be guided by the same ethical principle: a respect for patients' autonomy.
      We further suggest that if living organ donation valued donors' autonomy as much 
      as cosmetic plastic surgery does, we might witness a wider acceptance of and
      increase in living organ donation.
FAU - Testa, Giuliano
AU  - Testa G
AD  - Living Donor Liver Transplantation, Annette C. and Harold C. Simmons Transplant
      Institute at Baylor University Medical Center, Dallas, Texas, USA.
      giuliano.testa@baylorhealth.edu
FAU - Carlisle, Erica
AU  - Carlisle E
FAU - Simmerling, Mary
AU  - Simmerling M
FAU - Angelos, Peter
AU  - Angelos P
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Ethics
JT  - The Journal of clinical ethics
JID - 9114645
SB  - IM
CIN - J Clin Ethics. 2012 Summer;23(2):99-109. PMID: 22822697
CIN - J Clin Ethics. 2012 Summer;23(2):118-28. PMID: 22822699
CIN - J Clin Ethics. 2012 Fall;23(3):288. PMID: 23256409
MH  - *Coercion
MH  - Decision Making
MH  - Ethics, Medical
MH  - Humans
MH  - Informed Consent/ethics
MH  - *Living Donors
MH  - *Moral Obligations
MH  - Odds Ratio
MH  - Organ Transplantation/*ethics
MH  - Paternalism
MH  - *Personal Autonomy
MH  - Physician-Patient Relations/*ethics
MH  - Risk
MH  - Surgery, Plastic/*ethics
MH  - *Tissue and Organ Procurement
EDAT- 2012/07/25 06:00
MHDA- 2012/08/21 06:00
CRDT- 2012/07/25 06:00
PHST- 2012/07/25 06:00 [entrez]
PHST- 2012/07/25 06:00 [pubmed]
PHST- 2012/08/21 06:00 [medline]
PST - ppublish
SO  - J Clin Ethics. 2012 Summer;23(2):110-7.


PMID- 22822696
OWN - NLM
STAT- MEDLINE
DCOM- 20120814
LR  - 20220408
IS  - 0008-4174 (Print)
IS  - 0008-4174 (Linking)
VI  - 79
IP  - 3
DP  - 2012 Jun
TI  - A scoping review of the Photovoice method: implications for occupational therapy 
      research.
PG  - 181-90
AB  - BACKGROUND: Photovoice is a participatory action research method combining
      photography and group work to give people an opportunity to record and reflect on
      their daily lives. PURPOSE: To review the use of Photovoice in health research
      and consider the implications for occupational therapy research. METHODS:
      Literature review, guided by a scoping framework, reveals the purposes,
      rationales and populations with whom Photovoice has been used. FINDINGS: From 351
      documents retrieved, 191 original studies were surveyed; 68% were peer-reviewed. 
      The majority of studies (76%) occurred within the public health domain and a
      smaller percentage (24%) with individuals experiencing a specific illness and/or 
      disability, with very few (2%) documented in the occupational therapy literature.
      IMPLICATIONS: Photovoice provides a useful framework to apply a
      participant-centred research approach on occupational participation. It is
      important to consider and further examine ethical and methodological issues
      related to stigma, physical and cognitive capacities, mobility and technical
      accessibility related to using this method.
FAU - Lal, Shalini
AU  - Lal S
AD  - Rehabilitation Sciences Program, University of British Columbia, T-325, 2211
      Wesbrook Mall, Vancouver, BC, Canada V6T 2B5. lalsha@interchange.ubc.ca
FAU - Jarus, Tal
AU  - Jarus T
FAU - Suto, Melinda J
AU  - Suto MJ
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Can J Occup Ther
JT  - Canadian journal of occupational therapy. Revue canadienne d'ergotherapie
JID - 0406021
SB  - IM
MH  - *Group Processes
MH  - Humans
MH  - Occupational Therapy
MH  - *Photography
MH  - *Research Design
EDAT- 2012/07/25 06:00
MHDA- 2012/08/15 06:00
CRDT- 2012/07/25 06:00
PHST- 2012/07/25 06:00 [entrez]
PHST- 2012/07/25 06:00 [pubmed]
PHST- 2012/08/15 06:00 [medline]
AID - 10.2182/cjot.2012.79.3.8 [doi]
PST - ppublish
SO  - Can J Occup Ther. 2012 Jun;79(3):181-90. doi: 10.2182/cjot.2012.79.3.8.


PMID- 22822695
OWN - NLM
STAT- MEDLINE
DCOM- 20120814
LR  - 20170214
IS  - 0008-4174 (Print)
IS  - 0008-4174 (Linking)
VI  - 79
IP  - 3
DP  - 2012 Jun
TI  - Curriculum evaluation: linking curriculum objectives to essential competencies.
PG  - 175-80
AB  - BACKGROUND: The essential competencies of occupational therapy practice are
      agreed upon and documented (ACOTRO, 2003), yet they have not been used to
      evaluate educational programs. PURPOSE: To evaluate the match between the planned
      curriculum and the nationally recognized competencies that define safe,
      effective, and ethical practice. METHODS: Utilizing a comparative and systematic 
      approach, course learning objectives in the approved curriculum map were matched 
      to the ACOTRO (2003) competencies. FINDINGS: A total of 218 links were made
      between the 179 learning objectives and the 30 essential competencies. There were
      no links to three competencies. Learning objectives were not equally represented 
      across the ACOTRO units; initial analyses indicate the distribution is likely
      appropriate. IMPLICATIONS: This novel evaluative process allowed critical
      appraisal and subsequent minor revision of Dalhousie curriculum. The appropriate,
      relative weighting of curriculum content is unknown and is a professional issue
      for discussion by regulators, educators, and the profession at large.
FAU - Merritt, Brenda K
AU  - Merritt BK
AD  - School of Occupational Therapy, Dalhousie University, 5869 University Avenue, PO 
      Box 15000, Forrest Building Room 215, Halifax, NS, Canada B3H 4R2.
      b.merritt@dal.ca
FAU - Blake, Andrea I
AU  - Blake AI
FAU - McIntyre, Alison H
AU  - McIntyre AH
FAU - Packer, Tanya L
AU  - Packer TL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Can J Occup Ther
JT  - Canadian journal of occupational therapy. Revue canadienne d'ergotherapie
JID - 0406021
SB  - IM
MH  - Canada
MH  - Clinical Competence/*standards
MH  - *Curriculum
MH  - Educational Measurement
MH  - Humans
MH  - Occupational Therapy/*education/*standards
EDAT- 2012/07/25 06:00
MHDA- 2012/08/15 06:00
CRDT- 2012/07/25 06:00
PHST- 2012/07/25 06:00 [entrez]
PHST- 2012/07/25 06:00 [pubmed]
PHST- 2012/08/15 06:00 [medline]
AID - 10.2182/cjot.2012.79.3.7 [doi]
PST - ppublish
SO  - Can J Occup Ther. 2012 Jun;79(3):175-80. doi: 10.2182/cjot.2012.79.3.7.


PMID- 22822604
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20181201
IS  - 0012-7183 (Print)
IS  - 0012-7183 (Linking)
VI  - 128
IP  - 12
DP  - 2012
TI  - [Intensive care of a person refusing blood products].
PG  - 1283-7
AB  - In cases with severe anemia and significant hemorrhages, intensive care of a
      person refusing blood products is challenging. Owing to ethical aspects
      associated with conviction, treatment is easily subject to prejudice. Research
      data on this particular topic are insufficient, thus, treatment decisions are
      based on case reports. Treatment modalities that can be approved by the patients 
      should be scrutinized as early as possible and individuality taken into
      consideration. Epoetin, iron and vitamins are readily started. Attempts have to
      be made to guarantee adequate blood volume, oxygen transport and hemostasis.
      Mechanical ventilation, high fraction of inspired oxygen and sedation are
      utilized as supportive treatments, when severe anemia is improving.
FAU - Oittinen, Noora
AU  - Oittinen N
AD  - HUS, Meilahden sairaala, ATEK, Teho-os 20.
FAU - Korhonen, Anna-Maija
AU  - Korhonen AM
FAU - Kuitunen, Anne
AU  - Kuitunen A
LA  - fin
PT  - Journal Article
TT  - Verituotteista kieltaytyvan potilaan tehohoito.
PL  - Finland
TA  - Duodecim
JT  - Duodecim; laaketieteellinen aikakauskirja
JID - 0373207
RN  - 0 (Recombinant Proteins)
RN  - 0 (Vitamins)
RN  - 0 (epoetin beta)
RN  - 11096-26-7 (Erythropoietin)
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - Anemia/*therapy
MH  - Blood Transfusion/*statistics & numerical data
MH  - Conscious Sedation/methods
MH  - Critical Care/*methods
MH  - Erythropoietin/therapeutic use
MH  - Hemorrhage/*therapy
MH  - Humans
MH  - Iron/therapeutic use
MH  - Recombinant Proteins/therapeutic use
MH  - Respiration, Artificial
MH  - *Treatment Refusal
MH  - Vitamins/therapeutic use
EDAT- 2012/07/25 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/07/25 06:00
PHST- 2012/07/25 06:00 [entrez]
PHST- 2012/07/25 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
PST - ppublish
SO  - Duodecim. 2012;128(12):1283-7.


PMID- 22822200
OWN - NLM
STAT- MEDLINE
DCOM- 20130227
LR  - 20220409
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 12
DP  - 2012 Dec
TI  - Participants' responsibilities in clinical research.
PG  - 746-50
LID - 10.1136/medethics-2011-100319 [doi]
AB  - Discussions on the ethics and regulation of clinical research have a great deal
      to say about the responsibilities of investigators, sponsors, research
      institutions and institutional review boards, but very little about the
      responsibilities of research participants. In this article, we discuss the
      responsibilities of participants in clinical research. We argue that competent
      adult participants are responsible for complying with study requirements and
      fulfilling other obligations they undertake when they make an informed choice to 
      enroll in a study. These responsibilities are based on duties related to
      promise-keeping, avoiding harm to one's self or others, beneficence and
      reciprocity. Investigators and research staff should inform participants about
      their responsibilities during the consent process, and should stress the
      importance of fulfilling study requirements. They should address any impediments 
      to compliance, and they may provide participants with financial incentives for
      meeting study requirements. In very rare cases, coercive measures may be
      justified to prevent immanent harm to others resulting from non-compliance with
      study requirements.
FAU - Resnik, David B
AU  - Resnik DB
AD  - National Institute of Environmental Health Sciences (NIEHS), National Institutes 
      of Health (NIH), Research Triangle Park, NC 27709, USA. resnikd@niehs.nih.gov
FAU - Ness, Elizabeth
AU  - Ness E
LA  - eng
GR  - ZIA ES102646-03/Intramural NIH HHS/United States
GR  - ZIA ES102646-04/Intramural NIH HHS/United States
PT  - Journal Article
DEP - 20120719
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Adult
MH  - Beneficence
MH  - Choice Behavior
MH  - Clinical Trials as Topic/*ethics
MH  - Coercion
MH  - Deception
MH  - Female
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Income
MH  - Informed Consent/ethics
MH  - Male
MH  - Medication Adherence/statistics & numerical data
MH  - *Moral Obligations
MH  - Motivation
MH  - Personal Autonomy
MH  - *Research Subjects/psychology
MH  - Researcher-Subject Relations/*ethics
MH  - *Social Responsibility
PMC - PMC3962011
MID - NIHMS561114
EDAT- 2012/07/24 06:00
MHDA- 2013/02/28 06:00
CRDT- 2012/07/24 06:00
PHST- 2012/07/24 06:00 [entrez]
PHST- 2012/07/24 06:00 [pubmed]
PHST- 2013/02/28 06:00 [medline]
AID - medethics-2011-100319 [pii]
AID - 10.1136/medethics-2011-100319 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Dec;38(12):746-50. doi: 10.1136/medethics-2011-100319. Epub
      2012 Jul 19.


PMID- 22822049
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20161125
IS  - 1479-6813 (Electronic)
IS  - 0952-5041 (Linking)
VI  - 49
IP  - 2
DP  - 2012 Oct
TI  - Defining stem cell types: understanding the therapeutic potential of ESCs, ASCs, 
      and iPS cells.
PG  - R89-111
LID - 10.1530/JME-12-0072 [doi]
AB  - Embryonic, adult, artificially reprogrammed, and cancer...- there are various
      types of cells associated with stemness. Do they have something fundamental in
      common? Are we applying a common name to very different entities? In this review,
      we will revisit the characteristics that define 'pluripotency', the main property
      of stem cells (SCs). For each main type of physiological (embryonic and adult) or
      synthetic (induced pluripotent) SCs, markers and functional behavior in vitro and
      in vivo will be described. We will review the pioneering work that has led to
      obtaining human SC lines, together with the problems that have arisen, both in a 
      biological context (DNA alterations, heterogeneity, tumors, and immunogenicity)
      and with regard to ethical concerns. Such problems have led to proposals for new 
      operative procedures for growing human SCs of sufficiently high quality for use
      as models of disease and in human therapy. Finally, we will review the data from 
      the first clinical trials to use various types of SCs.
FAU - Alvarez, Clara V
AU  - Alvarez CV
AD  - Centro de Investigaciones Medicas e Instituto de Investigaciones Sanitarias
      (CIMUS-IDIS), Department of Physiology, University of Santiago de Compostela
      (USC), C/Barcelona S/N, 15782 Santiago de Compostela, Spain. clara.alvarez@usc.es
FAU - Garcia-Lavandeira, Montserrat
AU  - Garcia-Lavandeira M
FAU - Garcia-Rendueles, Maria E R
AU  - Garcia-Rendueles ME
FAU - Diaz-Rodriguez, Esther
AU  - Diaz-Rodriguez E
FAU - Garcia-Rendueles, Angela R
AU  - Garcia-Rendueles AR
FAU - Perez-Romero, Sihara
AU  - Perez-Romero S
FAU - Vila, Tania Vila
AU  - Vila TV
FAU - Rodrigues, Joana S
AU  - Rodrigues JS
FAU - Lear, Pamela V
AU  - Lear PV
FAU - Bravo, Susana B
AU  - Bravo SB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120830
PL  - England
TA  - J Mol Endocrinol
JT  - Journal of molecular endocrinology
JID - 8902617
RN  - 0 (Biomarkers)
RN  - 0 (CTNNB1 protein, human)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Nanog Homeobox Protein)
RN  - 0 (Nanog protein, mouse)
RN  - 0 (beta Catenin)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Cell Differentiation
MH  - Cell Line
MH  - Clinical Trials as Topic
MH  - Embryonic Stem Cells/cytology/physiology
MH  - Graft Rejection
MH  - Homeodomain Proteins/genetics/metabolism
MH  - Humans
MH  - Induced Pluripotent Stem Cells/cytology/physiology
MH  - Mice
MH  - Nanog Homeobox Protein
MH  - Pluripotent Stem Cells/metabolism
MH  - Promoter Regions, Genetic
MH  - Signal Transduction
MH  - *Stem Cell Transplantation
MH  - Stem Cells/cytology/*physiology
MH  - beta Catenin/physiology
EDAT- 2012/07/24 06:00
MHDA- 2013/02/13 06:00
CRDT- 2012/07/24 06:00
PHST- 2012/07/24 06:00 [entrez]
PHST- 2012/07/24 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
AID - JME-12-0072 [pii]
AID - 10.1530/JME-12-0072 [doi]
PST - epublish
SO  - J Mol Endocrinol. 2012 Aug 30;49(2):R89-111. doi: 10.1530/JME-12-0072. Print 2012
      Oct.


PMID- 22820733
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20220321
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 265
IP  - 1
DP  - 2012 Oct
TI  - Assessment of median nerve with MR neurography by using diffusion-tensor imaging:
      normative and pathologic diffusion values.
PG  - 194-203
AB  - PURPOSE: To determine normative diffusion values of the median nerve at several
      anatomic locations in healthy men and women of variable age and to compare these 
      normative values with those in patients with carpal tunnel syndrome. MATERIALS
      AND METHODS: After ethics board approval and written informed consent were
      obtained, 45 healthy volunteers (30 women, 15 men) and 15 patients (10 women,
      five men) were studied. Volunteers were divided into three age groups. Magnetic
      resonance (MR) neurography with diffusion-tensor imaging (DTI) was performed in
      all study participants at 3.0 T by using a single-shot echo-planar imaging
      sequence (repetition time msec/echo time msec, 10 123/40; b=1200 sec/mm2).
      Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) of the median
      nerve were determined by two readers at three locations: the levels of the distal
      radioulnar joint, pisiform bone, and hamate bone. RESULTS: Normative FA and ADC
      values were calculated for men and women, different age groups, and different
      anatomic locations. FA and ADC did not differ between men and women (P=.28 and
      P=.38, respectively). FA decreased and ADC increased when moving from proximal to
      distal locations (P<.001). FA decreased and ADC increased significantly with age 
      (P<.001). There was a significant difference between healthy volunteers and
      patients with carpal tunnel syndrome (P<.001 for both FA and ADC). An FA
      threshold of 0.47 and an ADC threshold of 1.054x10(-3) mm2/sec might be used in
      the diagnosis of carpal tunnel syndrome. CONCLUSION: Normative diffusion values
      for MR neurography of the median nerve with DTI depend on the anatomic location
      and age but not on sex. Age-specific FA and ADC threshold values might be used to
      diagnose carpal tunnel syndrome.
CI  - (c) RSNA, 2012.
FAU - Guggenberger, Roman
AU  - Guggenberger R
AD  - Department of Radiology, University Hospital Zurich, and Institute for Biomedical
      Engineering, University of Zurich, Ramistrasse 100, CH 8091 Zurich, Switzerland.
FAU - Markovic, Daniel
AU  - Markovic D
FAU - Eppenberger, Patrick
AU  - Eppenberger P
FAU - Chhabra, Avneesh
AU  - Chhabra A
FAU - Schiller, Andreas
AU  - Schiller A
FAU - Nanz, Daniel
AU  - Nanz D
FAU - Prussmann, Klaas
AU  - Prussmann K
FAU - Andreisek, Gustav
AU  - Andreisek G
LA  - eng
PT  - Journal Article
DEP - 20120719
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Analysis of Variance
MH  - Anisotropy
MH  - Carpal Tunnel Syndrome/*pathology
MH  - Case-Control Studies
MH  - Diffusion Tensor Imaging/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Median Nerve/*anatomy & histology/*pathology
MH  - Middle Aged
MH  - Prospective Studies
MH  - ROC Curve
MH  - Reference Values
EDAT- 2012/07/24 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/24 06:00
PHST- 2012/07/24 06:00 [entrez]
PHST- 2012/07/24 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - radiol.12111403 [pii]
AID - 10.1148/radiol.12111403 [doi]
PST - ppublish
SO  - Radiology. 2012 Oct;265(1):194-203. doi: 10.1148/radiol.12111403. Epub 2012 Jul
      19.


PMID- 22820319
OWN - NLM
STAT- MEDLINE
DCOM- 20130304
LR  - 20151119
IS  - 1559-2030 (Electronic)
IS  - 1551-7144 (Linking)
VI  - 33
IP  - 6
DP  - 2012 Nov
TI  - Ethical considerations and rationale of the MAKI trial: a multicenter
      double-blind randomized placebo-controlled trial into the preventive effect of
      palivizumab on recurrent wheezing associated with respiratory syncytial virus
      infection in children with a gestational age of 33-35 weeks.
PG  - 1287-92
LID - 10.1016/j.cct.2012.07.010 [doi]
LID - S1551-7144(12)00181-4 [pii]
AB  - BACKGROUND: Respiratory syncytial virus (RSV) lower respiratory tract infection
      (LRTI) is the most frequent cause of bronchiolitis during infancy. Long-term
      airway morbidity with recurrent post bronchiolitis wheezing (PBW) episodes, which
      are probably associated with respiratory infections, occurs in 30 to 70% of
      infants that were hospitalised with RSV LRTI. METHODS: We set up a multicenter,
      placebo-controlled double-blind randomized clinical trial in healthy preterm
      infants born between 33 and 35 weeks gestational age (WGA). The children received
      either one-monthly intramuscular palivizumab or placebo injection during the RSV 
      season with a minimum of 2 injections. RESULTS: The primary objective was to
      determine the preventive effect of RSV immunoprophylaxis (palivizumab) on the
      development of recurrent wheezing during the first year of life. The primary
      outcome measure was the number of wheezing days during the first year of life as 
      obtained by daily logs. As a secondary outcome nasal swabs were taken for viral
      analysis in case of respiratory symptoms. We will also examine wheezing at age 1,
      3 and 6 years both reported by the parents and the general practitioner and
      quality of life as secondary outcomes. This trial is possible because RSV
      immunoprophylaxis, although effective in this population, is not completely used 
      in the Netherlands due to its high costs. CONCLUSION: The Institutional review
      board (IRB) concluded the study has high clinical relevance because the benefit
      of 50% chance of protection by palivizumab outweighs the risk of side adverse
      events due to intramuscular administration of placebo.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Blanken, Maarten
AU  - Blanken M
AD  - University Medical Center Utrecht, Pediatric Immunology and Infectious Diseases, 
      Room KE.04.133.1, P.O. Box 85090, 3584 EA Utrecht, The Netherlands.
      m.o.blanken-2@umcutrecht.nl
FAU - Rovers, Maroeska
AU  - Rovers M
FAU - Sanders, Elisabeth
AU  - Sanders E
FAU - Bont, Louis
AU  - Bont L
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20120720
PL  - United States
TA  - Contemp Clin Trials
JT  - Contemporary clinical trials
JID - 101242342
RN  - 0 (Antibodies, Monoclonal, Humanized)
RN  - 0 (Antiviral Agents)
RN  - DQ448MW7KS (Palivizumab)
SB  - IM
MH  - Antibodies, Monoclonal, Humanized/*administration & dosage/therapeutic use
MH  - Antiviral Agents/*administration & dosage/therapeutic use
MH  - Double-Blind Method
MH  - *Ethics, Research
MH  - Female
MH  - Gestational Age
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Palivizumab
MH  - Recurrence
MH  - Respiratory Sounds/*drug effects/etiology
MH  - Respiratory Syncytial Virus Infections/complications/*prevention & control
EDAT- 2012/07/24 06:00
MHDA- 2013/03/05 06:00
CRDT- 2012/07/24 06:00
PHST- 2011/12/16 00:00 [received]
PHST- 2012/06/21 00:00 [revised]
PHST- 2012/07/16 00:00 [accepted]
PHST- 2012/07/24 06:00 [entrez]
PHST- 2012/07/24 06:00 [pubmed]
PHST- 2013/03/05 06:00 [medline]
AID - S1551-7144(12)00181-4 [pii]
AID - 10.1016/j.cct.2012.07.010 [doi]
PST - ppublish
SO  - Contemp Clin Trials. 2012 Nov;33(6):1287-92. doi: 10.1016/j.cct.2012.07.010. Epub
      2012 Jul 20.


PMID- 22820223
OWN - NLM
STAT- MEDLINE
DCOM- 20120925
LR  - 20140731
IS  - 1557-0541 (Print)
IS  - 1557-0541 (Linking)
VI  - 6
IP  - 2
DP  - 2012 Summer
TI  - Views of biobanking research among Alaska native people: the role of community
      context.
PG  - 131-9
LID - 10.1353/cpr.2012.0025 [doi]
AB  - BACKGROUND: Research using stored clinical data and samples held in biobanks has 
      potential to address health disparities in minority communities. However, ethical
      and cultural considerations about use of these samples for research warrant
      attention. Literature about how Alaska Native people (ANs) view biobanking
      research consists largely of theoretical papers and position statements with
      limited systematic information gathered from a broad range of ANs. OBJECTIVES: To
      explore the views of biobanking research among AN community members and leaders
      across Alaska using a community-based participatory research approach with tribal
      and federal partners. METHODS: We approached tribal health organizations (THOs)
      to partner and guide the study in their regions. Community liaisons were hired to
      lead study recruitment. Twenty-nine focus groups were conducted in 14 locations
      with participation from 82 community members and 81 tribal leaders. Data were
      analyzed using a grounded theory approach. RESULTS: We identified five themes
      that contributed to participants' views on biobanking: (1) Prior experiences with
      research and medical care, (2) stigmatizations, relevance, and applicability, (3)
      effects of governmental and cultural change, (4) concerns about unknown
      capability of future technologies, and (5) benefit for future generations.
      Respondents raised AN-specific cultural concerns along with global ethical
      concerns alongside the potential promise of research in improving AN health.
      CONCLUSIONS: This study offers considerations for researchers partnering with AN 
      communities when planning research and public health surveillance projects.
      Findings also have implications for other minority communities harmed by past
      research and other societal changes.
FAU - Hiratsuka, Vanessa
AU  - Hiratsuka V
AD  - Southcentral Foundation.
FAU - Brown, Jennifer
AU  - Brown J
FAU - Dillard, Denise
AU  - Dillard D
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Prog Community Health Partnersh
JT  - Progress in community health partnerships : research, education, and action
JID - 101273946
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alaska
MH  - *Biological Specimen Banks
MH  - *Biomedical Research
MH  - *Community-Based Participatory Research
MH  - Female
MH  - Humans
MH  - Inuits/*psychology
MH  - Male
MH  - Middle Aged
MH  - Prejudice
MH  - Public Opinion
MH  - Social Change
MH  - Young Adult
EDAT- 2012/07/24 06:00
MHDA- 2012/09/26 06:00
CRDT- 2012/07/24 06:00
PHST- 2012/07/24 06:00 [entrez]
PHST- 2012/07/24 06:00 [pubmed]
PHST- 2012/09/26 06:00 [medline]
AID - S1557055X12200063 [pii]
AID - 10.1353/cpr.2012.0025 [doi]
PST - ppublish
SO  - Prog Community Health Partnersh. 2012 Summer;6(2):131-9. doi:
      10.1353/cpr.2012.0025.


PMID- 22819925
OWN - NLM
STAT- MEDLINE
DCOM- 20131112
LR  - 20121203
IS  - 1878-5832 (Electronic)
IS  - 1359-6446 (Linking)
VI  - 17
IP  - 23-24
DP  - 2012 Dec
TI  - Decision theory and the evaluation of risks and benefits of clinical trials.
PG  - 1263-9
LID - 10.1016/j.drudis.2012.07.005 [doi]
LID - S1359-6446(12)00259-0 [pii]
AB  - Research ethics committees (RECs) are tasked to assess the risks and the benefits
      of a clinical trial. In previous studies, it was shown that RECs find this task
      difficult, if not impossible, to do. The current approaches to benefit-risk
      assessment (i.e. Component Analysis and the Net Risk Test) confound the various
      risk-benefit tasks, and as such, make balancing impossible. In this article, we
      show that decision theory, specifically through the expected utility theory and
      multiattribute utility theory, enable for an explicit and ethically weighted
      risk-benefit evaluation. This makes a balanced ethical justification possible,
      and thus a more rationally defensible decision making.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Bernabe, Rosemarie D C
AU  - Bernabe RD
AD  - Utrecht University Medical Center, Julius Center for Health Sciences and Primary 
      Care, Utrecht, The Netherlands. r.bernabe@umcutrecht.nl
FAU - van Thiel, Ghislaine J M W
AU  - van Thiel GJ
FAU - Raaijmakers, Jan A M
AU  - Raaijmakers JA
FAU - van Delden, Johannes J M
AU  - van Delden JJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120720
PL  - England
TA  - Drug Discov Today
JT  - Drug discovery today
JID - 9604391
SB  - IM
MH  - *Clinical Trials as Topic/ethics/standards
MH  - Decision Making
MH  - *Decision Support Techniques
MH  - *Decision Theory
MH  - Ethics Committees, Research
MH  - Principal Component Analysis
MH  - Risk Assessment
EDAT- 2012/07/24 06:00
MHDA- 2013/11/13 06:00
CRDT- 2012/07/24 06:00
PHST- 2012/02/17 00:00 [received]
PHST- 2012/06/05 00:00 [revised]
PHST- 2012/07/13 00:00 [accepted]
PHST- 2012/07/24 06:00 [entrez]
PHST- 2012/07/24 06:00 [pubmed]
PHST- 2013/11/13 06:00 [medline]
AID - S1359-6446(12)00259-0 [pii]
AID - 10.1016/j.drudis.2012.07.005 [doi]
PST - ppublish
SO  - Drug Discov Today. 2012 Dec;17(23-24):1263-9. doi: 10.1016/j.drudis.2012.07.005. 
      Epub 2012 Jul 20.


PMID- 22819821
OWN - NLM
STAT- MEDLINE
DCOM- 20121023
LR  - 20211021
IS  - 1873-3468 (Electronic)
IS  - 0014-5793 (Linking)
VI  - 586
IP  - 18
DP  - 2012 Aug 31
TI  - Generating pluripotent stem cells: differential epigenetic changes during
      cellular reprogramming.
PG  - 2874-81
LID - 10.1016/j.febslet.2012.07.024 [doi]
AB  - Pluripotent stem cells hold enomous potential for therapuetic applications in
      tissue replacement therapy. Reprogramming somatic cells from a patient donor to
      generate pluripotent stem cells involves both ethical concerns inherent in the
      use of embryonic and oocyte-derived stem cells, as well as issues of
      histocompatibility. Among the various pluripotent stem cells, induced pluripotent
      stem cells (iPSC)--derived by ectopic expression of four reprogramming factors in
      donor somatic cells--are superior in terms of ethical use, histocompatibility,
      and derivation method. However, iPSC also show genetic and epigenetic differences
      that limit their differentiation potential, functionality, safety, and potential 
      clinical utility. Here, we discuss the unique characteristics of iPSC and
      approaches that are being taken to overcome these limitations.
CI  - Copyright (c) 2012 Federation of European Biochemical Societies. Published by
      Elsevier B.V. All rights reserved.
FAU - Tobin, Stacey C
AU  - Tobin SC
AD  - Cancer Biology and Genetics Program, Center for Cell Engineering, Sloan-Kettering
      Institute, Gerstner Sloan-Kettering Graduate School of Biomedical Sciences, Weill
      Medical College of Cornell University, 1275 York Avenue, Box #484, New York, NY
      10065, United States.
FAU - Kim, Kitai
AU  - Kim K
LA  - eng
GR  - R00 HL093212/HL/NHLBI NIH HHS/United States
GR  - 4R00HL093212-03/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120720
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
SB  - IM
MH  - Animals
MH  - *Epigenesis, Genetic
MH  - Genomic Imprinting
MH  - Humans
MH  - Pluripotent Stem Cells/*cytology
PMC - PMC3589521
MID - NIHMS438169
EDAT- 2012/07/24 06:00
MHDA- 2012/10/24 06:00
CRDT- 2012/07/24 06:00
PHST- 2012/06/29 00:00 [received]
PHST- 2012/07/11 00:00 [revised]
PHST- 2012/07/11 00:00 [accepted]
PHST- 2012/07/24 06:00 [entrez]
PHST- 2012/07/24 06:00 [pubmed]
PHST- 2012/10/24 06:00 [medline]
AID - S0014-5793(12)00592-3 [pii]
AID - 10.1016/j.febslet.2012.07.024 [doi]
PST - ppublish
SO  - FEBS Lett. 2012 Aug 31;586(18):2874-81. doi: 10.1016/j.febslet.2012.07.024. Epub 
      2012 Jul 20.


PMID- 22819671
OWN - NLM
STAT- MEDLINE
DCOM- 20130214
LR  - 20120911
IS  - 1476-5616 (Electronic)
IS  - 0033-3506 (Linking)
VI  - 126
IP  - 9
DP  - 2012 Sep
TI  - Presentation and management of school bullying and the impact of anti-bullying
      strategies for pupils: a self-report survey in London schools.
PG  - 782-9
LID - 10.1016/j.puhe.2012.05.001 [doi]
AB  - OBJECTIVES: To investigate differences in the presentation and management of
      bullying in two London boroughs, one with high levels of deprivation and the
      other with low levels of deprivation; and to explore pupils' views on successful 
      approaches to tackle bullying. STUDY DESIGN: Problems associated with bullying in
      childhood can manifest with mental disorders, depression and poorer perceived
      health in adulthood. However, despite the recent development of anti-bullying
      policies within schools, bullying remains a significant issue for many pupils. An
      original self-report survey was undertaken to investigate this important area.
      METHOD: A web-based questionnaire was undertaken with pupils from year 8 (aged
      12-13 years) at four secondary schools in London. The study was approved by
      King's College London Research Ethics Committee. RESULTS: In total, 304 pupils
      completed the questionnaire, 55% of whom were affected by bullying at their
      school. Deprivation had no impact on the prevalence of pupils involved in a
      bullying culture. School membership is the most important independent factor for 
      determining bullying. CONCLUSIONS: Policy could be aimed at changing pupils'
      views on dealing with bullying, and it is vital that policies and practices
      around bullying are active and alive and do not become 'file fodder'.
CI  - Copyright (c) 2012 The Royal Society for Public Health. Published by Elsevier
      Ltd. All rights reserved.
FAU - Raynor, S
AU  - Raynor S
AD  - King's College London, London, UK. sophieraynor@doctors.org.uk
FAU - Wylie, A
AU  - Wylie A
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20120721
PL  - Netherlands
TA  - Public Health
JT  - Public health
JID - 0376507
SB  - IM
MH  - Adolescent
MH  - Bullying/*psychology
MH  - Child
MH  - Cluster Analysis
MH  - Female
MH  - Humans
MH  - London
MH  - Male
MH  - Prevalence
MH  - *Schools
MH  - Self Report
EDAT- 2012/07/24 06:00
MHDA- 2013/02/15 06:00
CRDT- 2012/07/24 06:00
PHST- 2011/04/20 00:00 [received]
PHST- 2012/03/01 00:00 [revised]
PHST- 2012/05/08 00:00 [accepted]
PHST- 2012/07/24 06:00 [entrez]
PHST- 2012/07/24 06:00 [pubmed]
PHST- 2013/02/15 06:00 [medline]
AID - S0033-3506(12)00154-0 [pii]
AID - 10.1016/j.puhe.2012.05.001 [doi]
PST - ppublish
SO  - Public Health. 2012 Sep;126(9):782-9. doi: 10.1016/j.puhe.2012.05.001. Epub 2012 
      Jul 21.


PMID- 22819342
OWN - NLM
STAT- MEDLINE
DCOM- 20130419
LR  - 20220316
IS  - 1590-3729 (Electronic)
IS  - 0939-4753 (Linking)
VI  - 22
IP  - 11
DP  - 2012 Nov
TI  - Genetic prediction of common diseases. Still no help for the clinical
      diabetologist!
PG  - 929-36
LID - 10.1016/j.numecd.2012.04.010 [doi]
LID - S0939-4753(12)00104-4 [pii]
AB  - Genome-wide association studies (GWAS) have identified several loci associated
      with many common, multifactorial diseases which have been recently used to market
      genetic testing directly to the consumers. We here addressed the clinical utility
      of such GWAS-derived genetic information in predicting type 2 diabetes mellitus
      (T2DM) and coronary artery disease (CAD) in diabetic patients. In addition, the
      development of new statistical approaches, novel technologies of genome
      sequencing and ethical, legal and social aspects related to genetic testing have 
      been also addressed. Available data clearly show that, similarly to what reported
      for most common diseases, genetic testing offered today by commercial companies
      cannot be used as predicting tools for T2DM and CAD. Further studies taking into 
      account the complex interaction between genes as well as between genetic and
      non-genetic factors, including age, obesity and glycemic control which seem to
      modify genetic effects on the risk of T2DM and CAD, might mitigate such negative 
      conclusions. Also, addressing the role of relatively rare variants by next
      generation sequencing may help identify novel and strong genetic markers with an 
      important role in genetic prediction. Finally, statistical tools concentrated on 
      reclassifying patients might be a useful application of genetic information for
      predicting many common diseases. By now, prediction of such diseases, including
      those of interest for the clinical diabetologist, have to be pursued by using
      traditional clinical markers which perform well and are not costly.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Prudente, S
AU  - Prudente S
AD  - IRCCS Casa Sollievo della Sofferenza, Mendel Laboratory, San Giovanni Rotondo,
      Italy.
FAU - Dallapiccola, B
AU  - Dallapiccola B
FAU - Pellegrini, F
AU  - Pellegrini F
FAU - Doria, A
AU  - Doria A
FAU - Trischitta, V
AU  - Trischitta V
LA  - eng
GR  - R01 HL073168/HL/NHLBI NIH HHS/United States
GR  - HL073168/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120721
PL  - Netherlands
TA  - Nutr Metab Cardiovasc Dis
JT  - Nutrition, metabolism, and cardiovascular diseases : NMCD
JID - 9111474
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Coronary Artery Disease/*genetics
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Gene Frequency
MH  - Genetic Counseling
MH  - Genetic Loci
MH  - Genetic Markers
MH  - *Genetic Predisposition to Disease
MH  - Genetic Testing
MH  - Genome-Wide Association Study/*methods
MH  - Humans
MH  - Models, Genetic
MH  - Obesity/genetics
MH  - Polymorphism, Single Nucleotide
MH  - Risk Factors
PMC - PMC3729722
MID - NIHMS491313
EDAT- 2012/07/24 06:00
MHDA- 2013/04/23 06:00
CRDT- 2012/07/24 06:00
PHST- 2012/01/17 00:00 [received]
PHST- 2012/03/26 00:00 [revised]
PHST- 2012/04/23 00:00 [accepted]
PHST- 2012/07/24 06:00 [entrez]
PHST- 2012/07/24 06:00 [pubmed]
PHST- 2013/04/23 06:00 [medline]
AID - S0939-4753(12)00104-4 [pii]
AID - 10.1016/j.numecd.2012.04.010 [doi]
PST - ppublish
SO  - Nutr Metab Cardiovasc Dis. 2012 Nov;22(11):929-36. doi:
      10.1016/j.numecd.2012.04.010. Epub 2012 Jul 21.


PMID- 22818733
OWN - NLM
STAT- MEDLINE
DCOM- 20120927
LR  - 20160523
IS  - 2212-2672 (Print)
IS  - 2212-2672 (Linking)
VI  - 112
IP  - 8
DP  - 2012 Aug
TI  - Ethical issues for students.
PG  - 1253-4
LID - 10.1016/j.jand.2012.06.017 [doi]
FAU - Braunstein, Nadine
AU  - Braunstein N
AD  - Towson University, Towson, MD, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Acad Nutr Diet
JT  - Journal of the Academy of Nutrition and Dietetics
JID - 101573920
SB  - IM
MH  - *Codes of Ethics
MH  - Dietetics/*ethics/standards
MH  - *Ethics, Professional
MH  - Humans
MH  - Plagiarism
MH  - Social Media/ethics
MH  - Students/*psychology
MH  - United States
EDAT- 2012/07/24 06:00
MHDA- 2012/09/28 06:00
CRDT- 2012/07/24 06:00
PHST- 2012/06/07 00:00 [received]
PHST- 2012/07/24 06:00 [entrez]
PHST- 2012/07/24 06:00 [pubmed]
PHST- 2012/09/28 06:00 [medline]
AID - S2212-2672(12)00751-4 [pii]
AID - 10.1016/j.jand.2012.06.017 [doi]
PST - ppublish
SO  - J Acad Nutr Diet. 2012 Aug;112(8):1253-4. doi: 10.1016/j.jand.2012.06.017.


PMID- 22818218
OWN - NLM
STAT- MEDLINE
DCOM- 20130128
LR  - 20211021
IS  - 1755-8794 (Electronic)
IS  - 1755-8794 (Linking)
VI  - 5
DP  - 2012 Jul 20
TI  - Patient-controlled encrypted genomic data: an approach to advance clinical
      genomics.
PG  - 31
LID - 10.1186/1755-8794-5-31 [doi]
AB  - BACKGROUND: The revolution in DNA sequencing technologies over the past decade
      has made it feasible to sequence an individual's whole genome at a relatively low
      cost. The potential value of the information generated by genomic technologies
      for medicine and society is enormous. However, in order for exome sequencing, and
      eventually whole genome sequencing, to be implemented clinically, a number of
      major challenges need to be overcome. For instance, obtaining meaningful
      informed-consent, managing incidental findings and the great volume of data
      generated (including multiple findings with uncertain clinical significance),
      re-interpreting the genomic data and providing additional counselling to patients
      as genetic knowledge evolves are issues that need to be addressed. It appears
      that medical genetics is shifting from the present "phenotype-first" medical
      model to a "data-first" model which leads to multiple complexities. DISCUSSION:
      This manuscript discusses the different challenges associated with integrating
      genomic technologies into clinical practice and describes a "phenotype-first"
      approach, namely, "Individualized Mutation-weighed Phenotype Search", and its
      benefits. The proposed approach allows for a more efficient prioritization of the
      genes to be tested in a clinical lab based on both the patient's phenotype and
      his/her entire genomic data. It simplifies "informed-consent" for clinical use of
      genomic technologies and helps to protect the patient's autonomy and privacy.
      Overall, this approach could potentially render widespread use of genomic
      technologies, in the immediate future, practical, ethical and clinically useful. 
      SUMMARY: The "Individualized Mutation-weighed Phenotype Search" approach allows
      for an incremental integration of genomic technologies into clinical practice. It
      ensures that we do not over-medicalize genomic data but, rather, continue our
      current medical model which is based on serving the patient's concerns. Service
      should not be solely driven by technology but rather by the medical needs and the
      extent to which a technology can be safely and effectively utilized.
FAU - Trakadis, Yannis J
AU  - Trakadis YJ
AD  - Department of Medical Genetics, Montreal Children's Hospital-McGill University
      Health Centre, 2300 Tupper, Montreal, QC, Canada. john.trakadis@mail.mcgill.ca
LA  - eng
PT  - Journal Article
DEP - 20120720
PL  - England
TA  - BMC Med Genomics
JT  - BMC medical genomics
JID - 101319628
SB  - IM
MH  - *Computer Security
MH  - Data Mining/*methods
MH  - Disease/genetics
MH  - Genomics/*methods
MH  - Humans
MH  - Mutation
MH  - *Patients
MH  - Phenotype
PMC - PMC3439266
EDAT- 2012/07/24 06:00
MHDA- 2013/01/29 06:00
CRDT- 2012/07/24 06:00
PHST- 2011/12/15 00:00 [received]
PHST- 2012/06/30 00:00 [accepted]
PHST- 2012/07/24 06:00 [entrez]
PHST- 2012/07/24 06:00 [pubmed]
PHST- 2013/01/29 06:00 [medline]
AID - 1755-8794-5-31 [pii]
AID - 10.1186/1755-8794-5-31 [doi]
PST - epublish
SO  - BMC Med Genomics. 2012 Jul 20;5:31. doi: 10.1186/1755-8794-5-31.


PMID- 22818153
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20120723
IS  - 1865-9217 (Print)
IS  - 1865-9217 (Linking)
VI  - 106
IP  - 5
DP  - 2012
TI  - [Assessing the effectiveness of medical devices in patient-oriented surgical
      research].
PG  - 336-40; discussion 341
LID - 10.1016/j.zefq.2012.05.005 [doi]
AB  - Surgery depends on the application of therapeutic procedures that are based on
      scientific evidence. It legitimises its claim in patient care through operations 
      with proven benefit consisting of cure or improvement of symptoms. Moreover,
      clinical research and evaluation of surgical technique, strategy and innovation
      is closely entangled with medical devices. These surgical trials are regulated
      beyond the German drug and medical devices law, but scientific and ethical rules 
      still follow the principles of clinical epidemiology and evidence-based medicine.
      Standardisation of surgical and perioperative care is the inevitable prerequisite
      in clinical trials to define and to evaluate effectiveness of surgical devices.
      The Study Centre of the German Surgical Society has established an efficient
      infrastructure for such trials in Germany and is working to refine the scientific
      methodology in order to improve the current basis of evidence. (As supplied by
      publisher).
CI  - Copyright (c) 2012. Published by Elsevier GmbH.
FAU - Diener, Markus K
AU  - Diener MK
AD  - Studienzentrum der Deutschen Gesellschaft fur Chirurgie, Heidelberg.
      markus.diener@med.uni-heidelberg.de
FAU - Dorr-Harim, Colette
AU  - Dorr-Harim C
FAU - Rossion, Inga
AU  - Rossion I
FAU - Buchler, Markus W
AU  - Buchler MW
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Die Nutzenbewertung von Medizinprodukten in der chirurgischen,
      patientenorientierten Forschung.
DEP - 20120606
PL  - Netherlands
TA  - Z Evid Fortbild Qual Gesundhwes
JT  - Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen
JID - 101477604
SB  - IM
MH  - Device Approval/*standards
MH  - Evidence-Based Medicine/legislation & jurisprudence/standards
MH  - Germany
MH  - Humans
MH  - Multicenter Studies as Topic/legislation & jurisprudence/standards
MH  - *National Health Programs/legislation & jurisprudence
MH  - *Patient-Centered Care
MH  - Product Surveillance, Postmarketing/standards
MH  - Quality Assurance, Health Care/standards
MH  - Randomized Controlled Trials as Topic/legislation & jurisprudence/standards
MH  - Surgical Equipment/*standards
MH  - Surgical Instruments/*standards
MH  - Treatment Outcome
EDAT- 2012/07/24 06:00
MHDA- 2012/11/14 06:00
CRDT- 2012/07/24 06:00
PHST- 2012/07/24 06:00 [entrez]
PHST- 2012/07/24 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
AID - S1865-9217(12)00119-5 [pii]
AID - 10.1016/j.zefq.2012.05.005 [doi]
PST - ppublish
SO  - Z Evid Fortbild Qual Gesundhwes. 2012;106(5):336-40; discussion 341. doi:
      10.1016/j.zefq.2012.05.005. Epub 2012 Jun 6.


PMID- 22818109
OWN - NLM
STAT- MEDLINE
DCOM- 20130227
LR  - 20211021
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 13
DP  - 2012 Jul 20
TI  - Ethical and legal constraints to children's participation in research in
      Zimbabwe: experiences from the multicenter pediatric HIV ARROW trial.
PG  - 17
LID - 10.1186/1472-6939-13-17 [doi]
AB  - BACKGROUND: Clinical trials involving children previously considered unethical
      are now considered essential because of the inherent physiological differences
      between children and adults. An integral part of research ethics is the informed 
      consent, which for children is obtained by proxy from a consenting parent or
      guardian. The informed consent process is governed by international ethical codes
      that are interpreted in accordance with local laws and procedures raising the
      importance of contextualizing their implementation. FINDINGS: In Zimbabwe the
      parental informed consent document for children participating in clinical
      research is modeled after Western laws of ethics and requires that the parent or 
      legally authorized representative provide consent on behalf of a minor. This
      article highlights the experiences and lessons learnt by Zimbabwean researchers
      in obtaining informed consent from guardians of orphaned children participating
      in a collaborative HIV clinical trial involving the Medical Research Council,
      United Kingdom and four centers, three of which are in Uganda. Researchers were
      faced with a situation where caregivers of orphaned children were not permitted
      to provide informed consent for trial participation. The situation contrasted
      with general clinical practice where consent for procedures on orphans is
      obtained from their caregivers who are not legal guardians. CONCLUSION: The
      challenges faced in obtaining informed consent for orphans in this clinical trial
      underscores the need for the Zimbabwe ethics committee to develop an ethical and 
      legal framework for pediatric research that is based on international guidelines 
      while taking into account the cultural context. The Medical Research Council of
      Zimbabwe has since started the process that is expected to involve critical
      stakeholders namely the community including children, ethicists, the legal
      fraternity and researchers.
FAU - Bwakura-Dangarembizi, Mutsa
AU  - Bwakura-Dangarembizi M
AD  - Department of Pediatrics and Child Health, University of Zimbabwe College of
      Health Sciences, Box A178, Avondale, Harare, Zimbabwe. dangas@zol.co.zw
FAU - Musesengwa, Rosemary
AU  - Musesengwa R
FAU - Nathoo, Kusum J
AU  - Nathoo KJ
FAU - Takaidza, Patrick
AU  - Takaidza P
FAU - Mhute, Tawanda
AU  - Mhute T
FAU - Vhembo, Tichaona
AU  - Vhembo T
LA  - eng
GR  - Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120720
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - Adult
MH  - Anti-HIV Agents/therapeutic use
MH  - *Caregivers
MH  - Child
MH  - *Child, Orphaned
MH  - Clinical Trials as Topic/*ethics/*legislation & jurisprudence
MH  - Female
MH  - HIV Infections/*drug therapy
MH  - Humans
MH  - *Legal Guardians
MH  - Male
MH  - Multicenter Studies as Topic/ethics/legislation & jurisprudence
MH  - Parental Consent/*ethics/*legislation & jurisprudence
MH  - Research Subjects
MH  - Uganda
MH  - Zimbabwe
PMC - PMC3521203
EDAT- 2012/07/24 06:00
MHDA- 2013/02/28 06:00
CRDT- 2012/07/24 06:00
PHST- 2011/06/17 00:00 [received]
PHST- 2012/07/05 00:00 [accepted]
PHST- 2012/07/24 06:00 [entrez]
PHST- 2012/07/24 06:00 [pubmed]
PHST- 2013/02/28 06:00 [medline]
AID - 1472-6939-13-17 [pii]
AID - 10.1186/1472-6939-13-17 [doi]
PST - epublish
SO  - BMC Med Ethics. 2012 Jul 20;13:17. doi: 10.1186/1472-6939-13-17.


PMID- 22817979
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20220317
IS  - 1550-2783 (Electronic)
IS  - 1550-2783 (Linking)
VI  - 9
IP  - 1
DP  - 2012 Jul 20
TI  - Creatine supplementation with specific view to exercise/sports performance: an
      update.
PG  - 33
LID - 10.1186/1550-2783-9-33 [doi]
AB  - Creatine is one of the most popular and widely researched natural supplements.
      The majority of studies have focused on the effects of creatine monohydrate on
      performance and health; however, many other forms of creatine exist and are
      commercially available in the sports nutrition/supplement market. Regardless of
      the form, supplementation with creatine has regularly shown to increase strength,
      fat free mass, and muscle morphology with concurrent heavy resistance training
      more than resistance training alone. Creatine may be of benefit in other modes of
      exercise such as high-intensity sprints or endurance training. However, it
      appears that the effects of creatine diminish as the length of time spent
      exercising increases. Even though not all individuals respond similarly to
      creatine supplementation, it is generally accepted that its supplementation
      increases creatine storage and promotes a faster regeneration of adenosine
      triphosphate between high intensity exercises. These improved outcomes will
      increase performance and promote greater training adaptations. More recent
      research suggests that creatine supplementation in amounts of 0.1 g/kg of body
      weight combined with resistance training improves training adaptations at a
      cellular and sub-cellular level. Finally, although presently ingesting creatine
      as an oral supplement is considered safe and ethical, the perception of safety
      cannot be guaranteed, especially when administered for long period of time to
      different populations (athletes, sedentary, patient, active, young or elderly).
FAU - Cooper, Robert
AU  - Cooper R
AD  - Centre for Sports Science and Human Performance, School of Science, University of
      Greenwich at Medway, Central Avenue, Chatham Maritime, Kent, ME4 4TB, United
      Kingdom. cr86@gre.ac.uk.
FAU - Naclerio, Fernando
AU  - Naclerio F
FAU - Allgrove, Judith
AU  - Allgrove J
FAU - Jimenez, Alfonso
AU  - Jimenez A
LA  - eng
PT  - Journal Article
DEP - 20120720
PL  - United States
TA  - J Int Soc Sports Nutr
JT  - Journal of the International Society of Sports Nutrition
JID - 101234168
PMC - PMC3407788
EDAT- 2012/07/24 06:00
MHDA- 2012/07/24 06:01
CRDT- 2012/07/24 06:00
PHST- 2012/03/26 00:00 [received]
PHST- 2012/07/20 00:00 [accepted]
PHST- 2012/07/24 06:00 [entrez]
PHST- 2012/07/24 06:00 [pubmed]
PHST- 2012/07/24 06:01 [medline]
AID - 1550-2783-9-33 [pii]
AID - 10.1186/1550-2783-9-33 [doi]
PST - epublish
SO  - J Int Soc Sports Nutr. 2012 Jul 20;9(1):33. doi: 10.1186/1550-2783-9-33.


PMID- 22817658
OWN - NLM
STAT- MEDLINE
DCOM- 20130423
LR  - 20211021
IS  - 1477-3155 (Electronic)
IS  - 1477-3155 (Linking)
VI  - 10
DP  - 2012 Jul 20
TI  - Prospects and applications of nanobiotechnology: a medical perspective.
PG  - 31
LID - 10.1186/1477-3155-10-31 [doi]
AB  - BACKGROUND: Nanobiotechnology is the application of nanotechnology in biological 
      fields. Nanotechnology is a multidisciplinary field that currently recruits
      approach, technology and facility available in conventional as well as advanced
      avenues of engineering, physics, chemistry and biology. METHOD: A comprehensive
      review of the literature on the principles, limitations, challenges, improvements
      and applications of nanotechnology in medical science was performed. RESULTS:
      Nanobiotechnology has multitude of potentials for advancing medical science
      thereby improving health care practices around the world. Many novel
      nanoparticles and nanodevices are expected to be used, with an enormous positive 
      impact on human health. While true clinical applications of nanotechnology are
      still practically inexistent, a significant number of promising medical projects 
      are in an advanced experimental stage. Implementation of nanotechnology in
      medicine and physiology means that mechanisms and devices are so technically
      designed that they can interact with sub-cellular (i.e. molecular) levels of the 
      body with a high degree of specificity. Thus therapeutic efficacy can be achieved
      to maximum with minimal side effects by means of the targeted cell or
      tissue-specific clinical intervention. CONCLUSION: More detailed research and
      careful clinical trials are still required to introduce diverse components of
      nanobiotechnology in random clinical applications with success. Ethical and moral
      concerns also need to be addressed in parallel with the new developments.
FAU - Fakruddin, Md
AU  - Fakruddin M
AD  - Institute of Food Science and Technology (IFST), Bangladesh Council of Scientific
      and Industrial Research (BCSIR), Dhaka, Bangladesh. fakruddinmurad@gmail.com
FAU - Hossain, Zakir
AU  - Hossain Z
FAU - Afroz, Hafsa
AU  - Afroz H
LA  - eng
PT  - Journal Article
PT  - Retracted Publication
PT  - Review
DEP - 20120720
PL  - England
TA  - J Nanobiotechnology
JT  - Journal of nanobiotechnology
JID - 101152208
SB  - IM
RIN - J Nanobiotechnology. 2012;10:40. PMID: 23036117
MH  - Biomedical Technology/*methods
MH  - Biotechnology/*methods
MH  - Humans
MH  - Nanotechnology/*methods
PMC - PMC3422163
EDAT- 2012/07/24 06:00
MHDA- 2013/04/24 06:00
CRDT- 2012/07/24 06:00
PHST- 2012/06/03 00:00 [received]
PHST- 2012/07/20 00:00 [accepted]
PHST- 2012/07/24 06:00 [entrez]
PHST- 2012/07/24 06:00 [pubmed]
PHST- 2013/04/24 06:00 [medline]
AID - 1477-3155-10-31 [pii]
AID - 10.1186/1477-3155-10-31 [doi]
PST - epublish
SO  - J Nanobiotechnology. 2012 Jul 20;10:31. doi: 10.1186/1477-3155-10-31.


PMID- 22816445
OWN - NLM
STAT- MEDLINE
DCOM- 20131206
LR  - 20130513
IS  - 1471-6712 (Electronic)
IS  - 0283-9318 (Linking)
VI  - 27
IP  - 2
DP  - 2013 Jun
TI  - Measuring patient satisfaction with the Polish version of the Newcastle
      Satisfaction with Nursing Scale.
PG  - 311-8
LID - 10.1111/j.1471-6712.2012.01034.x [doi]
AB  - The measurement of patients' satisfaction is increasingly becoming legal and
      ethical duty of healthcare providers worldwide. Till now, there were no
      validated, widely available Polish scales to assess patients' satisfaction with
      nursing care. The aim of this study was to assess the experiences and
      satisfaction with nursing care of patients hospitalized in surgical and
      nonsurgical wards in Poland using Polish version of the Newcastle Satisfaction
      with Nursing Scale. This is a multicentre, cross-sectional, descriptive study.
      Eight hospitals were qualified to participate in a convenience manner. The
      correlations between variables were analysed using the Mann-Whitney or the
      Kruskal-Wallis tests. In the case of a significant correlation, the Dunn's test
      was used to conduct multiple comparisons for the group of variables. A
      significance of alpha = 0.05 was assumed for the tests. A total 918 patients
      participated in the study, and 787 (85.72%) questionnaires were correctly filled 
      out. The average result on the 'experience' scale was 73.22 (Me 73.07) and on the
      'satisfaction' scale, 74.98 (Me 76.31). Education levels did not affect the
      experiences of nursing care levels p = 0.2204 and satisfaction with nursing care 
      p = 0.1075. Patient age had a statistically significant impact on the results of 
      the 'experiences of nursing care' scale p = 0.0005 and the 'satisfaction with
      nursing' scale p = 0.0194. The experiences of nursing care (p = 0.0002) and
      patients satisfaction (p = 0.0000) were significantly higher in surgical wards
      than in nonsurgical wards. The experiences of nursing care were significantly
      lower in the university hospital than in provincial hospitals (p = 0.0374) and
      district hospitals (p = 0.0183). A comparison of patient satisfaction with
      nursing in various hospitals shows that patients were most satisfied in district 
      hospitals (average 78.10, Me 82.89), followed by provincial hospitals (average
      72.11, Me 76.31) and the university hospital (average 70.64, Me 71.05).
CI  - (c) 2012 Nordic College of Caring Science.
FAU - Gutysz-Wojnicka, Aleksandra
AU  - Gutysz-Wojnicka A
AD  - Department of Nursing, Faculty of Medical Sciences, University of Warmia and
      Mazury in Olsztyn, Poland. olagut@go2.pl
FAU - Dyk, Danuta
AU  - Dyk D
FAU - Cudak, Edyta
AU  - Cudak E
FAU - Ozga, Dorota
AU  - Ozga D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120722
PL  - Sweden
TA  - Scand J Caring Sci
JT  - Scandinavian journal of caring sciences
JID - 8804206
MH  - Adult
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nursing Process/*standards
MH  - *Patient Satisfaction
MH  - Poland
MH  - Quality of Health Care
EDAT- 2012/07/24 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/07/24 06:00
PHST- 2012/07/24 06:00 [entrez]
PHST- 2012/07/24 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1111/j.1471-6712.2012.01034.x [doi]
PST - ppublish
SO  - Scand J Caring Sci. 2013 Jun;27(2):311-8. doi: 10.1111/j.1471-6712.2012.01034.x. 
      Epub 2012 Jul 22.


PMID- 22816192
OWN - NLM
STAT- MEDLINE
DCOM- 20120814
LR  - 20211203
IS  - 0350-6134 (Print)
IS  - 0350-6134 (Linking)
VI  - 36
IP  - 1
DP  - 2012 Mar
TI  - A critique of race-based and genomic medicine.
PG  - 5-10
AB  - Now that a composite human genome has been sequenced (HGP), research has
      accelerated to discover precise genetic bases of several chronic health issues,
      particularly in the realms of cancer and cardiovascular disease. It is
      anticipated that in the future it will be possible and cost effective to
      regularly sequence individual genomes, and thereby produce a DNA profile that
      potentially can be used to assess the health risks for each person with respect
      to certain genetically predisposed conditions. Coupled with that enormous
      diagnostic power, it will then depend upon equally rapid research efforts to
      develop personalized courses of treatment, including that of pharmaceutical
      therapy. Initial treatment attempts have been made to match drug efficacy and
      safety to individuals of assigned or self-identified groups according to their
      genetic ancestry or presumed race. A prime example is that of BiDil, which was
      the first drug approved by the US FDA for the explicit treatment of heart
      patients of African American ancestry. This race-based approach to medicine has
      been met with justifiable criticism, notably on ethical grounds that have long
      plagued historical applications and misuses of human race classification, and
      also on questionable science. This paper will assess race-based medical research 
      and practice in light of a more thorough understanding of human genetic
      variability. Additional concerns will be expressed with regard to the rapidly
      developing area of pharmacogenomics, promoted to be the future of personalized
      medicine. Genomic epidemiology will be discussed with several examples of
      on-going research that hopefully will provide a solid scientific grounding for
      personalized medicine to build upon.
FAU - Meier, Robert J
AU  - Meier RJ
AD  - Indiana University, Department of Anthropology, Bloomington, IN 47408, USA.
      meier@indiana.edu
LA  - eng
PT  - Journal Article
PL  - Croatia
TA  - Coll Antropol
JT  - Collegium antropologicum
JID - 8003354
SB  - IM
MH  - Genomics/*standards/*trends
MH  - *Human Genome Project
MH  - Humans
MH  - Pharmacogenetics/standards/trends
MH  - Precision Medicine/standards/trends
MH  - Racial Groups/*genetics
EDAT- 2012/07/24 06:00
MHDA- 2012/08/15 06:00
CRDT- 2012/07/24 06:00
PHST- 2012/07/24 06:00 [entrez]
PHST- 2012/07/24 06:00 [pubmed]
PHST- 2012/08/15 06:00 [medline]
PST - ppublish
SO  - Coll Antropol. 2012 Mar;36(1):5-10.


PMID- 22815943
OWN - NLM
STAT- MEDLINE
DCOM- 20130116
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 7
DP  - 2012
TI  - Enhanced antitumor efficacy of a vascular disrupting agent combined with an
      antiangiogenic in a rat liver tumor model evaluated by multiparametric MRI.
PG  - e41140
LID - 10.1371/journal.pone.0041140 [doi]
AB  - A key problem in solid tumor therapy is tumor regrowth from a residual viable rim
      after treatment with a vascular disrupting agent (VDA). As a potential solution, 
      we studied a combined treatment of a VDA and antiangiogenic. This study was
      approved by the institutional ethical committee for the use and care of
      laboratory animals. Rats with implanted liver tumors were randomized into four
      treatment groups: 1) Zd6126 (Zd); 2) Thalidomide (Tha); 3) Zd in combination with
      Tha (ZdTha); and 4) controls. Multiparametric MRIs were performed and quantified 
      before and after treatment. Circulating endothelial progenitor cells (EPCs) and
      plasma stromal cell-derived factor-1alpha (SDF-1alpha) were monitored. Tumor
      apoptosis, necrosis, and microvessels were verified by histopathology. A single
      use of Zd or Tha did not significantly delay tumor growth. The combined ZdTha
      showed enhanced antitumor efficacy due to synergistic effects; it induced a
      cumulative tumor apoptosis or necrosis, which resulted in significant delay in
      tumor growth and reduction in the viable tumor rim; it also reduced tumor vessel 
      permeability; and it improved tumor hemodynamic indexes, most likely via a
      transient normalization of tumor vasculature induced by Tha. A stepwise linear
      regression analysis showed that the apparent diffusion coefficient was an
      independent predictor of tumor growth. We found no significant increases in
      Zd-induced circulating EPCs or plasma SDF-1alpha. ZdTha showed improved
      therapeutic efficacy in solid tumors compared to either agent alone. The
      therapeutic effects were successfully tracked in vivo with multiparametric MRI.
FAU - Chen, Feng
AU  - Chen F
AD  - Theragnostic Laboratory, Department of Imaging and Pathology, University
      Hospital, University of Leuven, Leuven, Belgium. feng.chen@med.kuleuven.be
FAU - Feng, Yingmei
AU  - Feng Y
FAU - Zheng, Kaier
AU  - Zheng K
FAU - De Keyzer, Frederik
AU  - De Keyzer F
FAU - Li, Junjie
AU  - Li J
FAU - Feng, Yuanbo
AU  - Feng Y
FAU - Cona, Marlein Miranda
AU  - Cona MM
FAU - Wang, Huaijun
AU  - Wang H
FAU - Jiang, Yansheng
AU  - Jiang Y
FAU - Yu, Jie
AU  - Yu J
FAU - Marchal, Guy
AU  - Marchal G
FAU - Verfaillie, Catherine
AU  - Verfaillie C
FAU - De Geest, Bart
AU  - De Geest B
FAU - Oyen, Raymond
AU  - Oyen R
FAU - Ni, Yicheng
AU  - Ni Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120718
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Angiogenesis Inhibitors)
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Chemokine CXCL12)
RN  - 0 (N-acetylcochinol-O-phosphate)
RN  - 0 (Organophosphorus Compounds)
RN  - 4Z8R6ORS6L (Thalidomide)
SB  - IM
MH  - Angiogenesis Inhibitors/*administration & dosage
MH  - Animals
MH  - Antineoplastic Agents/*pharmacology
MH  - Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
MH  - Apoptosis
MH  - Chemokine CXCL12/blood
MH  - Endothelial Cells/cytology
MH  - Humans
MH  - Liver Neoplasms/blood supply/*drug therapy
MH  - Magnetic Resonance Imaging/methods
MH  - Microcirculation
MH  - Necrosis
MH  - Organophosphorus Compounds/*administration & dosage
MH  - Rats
MH  - Stem Cells/cytology
MH  - Thalidomide/*administration & dosage
PMC - PMC3399789
EDAT- 2012/07/21 06:00
MHDA- 2013/01/17 06:00
CRDT- 2012/07/21 06:00
PHST- 2012/04/28 00:00 [received]
PHST- 2012/06/17 00:00 [accepted]
PHST- 2012/07/21 06:00 [entrez]
PHST- 2012/07/21 06:00 [pubmed]
PHST- 2013/01/17 06:00 [medline]
AID - 10.1371/journal.pone.0041140 [doi]
AID - PONE-D-12-12174 [pii]
PST - ppublish
SO  - PLoS One. 2012;7(7):e41140. doi: 10.1371/journal.pone.0041140. Epub 2012 Jul 18.


PMID- 22815652
OWN - NLM
STAT- MEDLINE
DCOM- 20121116
LR  - 20220408
IS  - 1549-1676 (Electronic)
IS  - 1549-1277 (Linking)
VI  - 9
IP  - 7
DP  - 2012
TI  - The ethics of switch/simplify in antiretroviral trials: non-inferior or just
      inferior?
PG  - e1001240
LID - 10.1371/journal.pmed.1001240 [doi]
FAU - Carr, Andrew
AU  - Carr A
AD  - Clinical Research Program, Centre for Applied Medical Research, St Vincent's
      Hospital, Sydney, Australia. acarr@stvincents.com.au
FAU - Hoy, Jennifer
AU  - Hoy J
FAU - Pozniak, Anton
AU  - Pozniak A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120717
PL  - United States
TA  - PLoS Med
JT  - PLoS medicine
JID - 101231360
SB  - IM
MH  - Antiretroviral Therapy, Highly Active/*ethics
MH  - Clinical Trials as Topic/*ethics
MH  - Humans
MH  - Practice Patterns, Physicians'
MH  - Risk Factors
PMC - PMC3398965
EDAT- 2012/07/21 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/21 06:00
PHST- 2012/07/21 06:00 [entrez]
PHST- 2012/07/21 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1371/journal.pmed.1001240 [doi]
AID - PMEDICINE-D-12-00227 [pii]
PST - ppublish
SO  - PLoS Med. 2012;9(7):e1001240. doi: 10.1371/journal.pmed.1001240. Epub 2012 Jul
      17.


PMID- 22815539
OWN - NLM
STAT- MEDLINE
DCOM- 20130108
LR  - 20151119
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 11
DP  - 2012 Nov
TI  - Quantitative valuation placed by children and teenagers on participation in two
      hypothetical research scenarios.
PG  - 686-91
LID - 10.1136/medethics-2012-100523 [doi]
AB  - For paediatric medicine to advance, research must be conducted specifically with 
      children. Concern about poor recruitment has led to debate about payments to
      child research participants. Although concerns about undue influence by such
      'compensation' have been expressed, it is useful to determine whether children
      can relate the time and inconvenience associated with participation to the value 
      of payment offered. This study explores children's ability to determine fair
      remuneration for research participation, and reviews payments to children
      participating in research. Forty children were interviewed before outpatient
      visits at two London Hospitals: Great Ormond Street Children's Hospital and the
      Whittington Hospital District General Hospital. Children were asked to value
      their involvement in two hypothetical research scenarios - the first an
      'additional blood sample', the second also involving daily oral oil capsules
      taken for a fortnight before further venesection. Background knowledge about
      familiarity with money, and experience with hospitalisation was assessed. The
      mean valuation of involvement in the second scenario ( pound13.18) was higher
      than in the first ( pound2.84) (p<0.001). This higher valuation persisted when
      children were categorised into groups 'aged 12+' and 'below 12'. Those undergoing
      a blood test on the day placed a higher valuation on participation in the second 
      scenario ( pound10.43, pound21.67, p=0.044). These children aged 8-16
      demonstrated the capacity to discern a fair valuation for participation in
      medical research. The monetary sums are influenced by the time and inconvenience 
      involved in the research, and by the extent of recent experience with hospital
      procedures. The authors review current ethical thinking regarding payments to
      child research participants and suggest that a fair wage model might be an
      ethically acceptable way to increase participation of children in research.
FAU - Funnell, Dan
AU  - Funnell D
AD  - Department of Paediatrics, Institute of Child Health, London, UK.
FAU - Fertleman, Caroline
AU  - Fertleman C
FAU - Carrey, Liz
AU  - Carrey L
FAU - Brierley, Joe
AU  - Brierley J
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20120719
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
RN  - 0 (Capsules)
SB  - IM
MH  - Administration, Oral
MH  - *Adolescent
MH  - Biomedical Research/*methods
MH  - Capsules
MH  - *Child
MH  - Hospitalization
MH  - Humans
MH  - London
MH  - Patient Selection
MH  - Research Subjects/*economics/psychology/supply & distribution
MH  - *Salaries and Fringe Benefits/economics
MH  - Specimen Handling
MH  - Surveys and Questionnaires
EDAT- 2012/07/21 06:00
MHDA- 2013/01/09 06:00
CRDT- 2012/07/21 06:00
PHST- 2012/07/21 06:00 [entrez]
PHST- 2012/07/21 06:00 [pubmed]
PHST- 2013/01/09 06:00 [medline]
AID - medethics-2012-100523 [pii]
AID - 10.1136/medethics-2012-100523 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Nov;38(11):686-91. doi: 10.1136/medethics-2012-100523. Epub
      2012 Jul 19.


PMID- 22815471
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 4
DP  - 2012
TI  - An HIV/STI prevention intervention for internally displaced women in Leogane,
      Haiti: study protocol for an N-of-1 pilot study.
LID - 10.1136/bmjopen-2012-001634 [doi]
LID - e001634 [pii]
AB  - INTRODUCTION: Haiti has the highest HIV infection rate in the Western hemisphere,
      with approximately one in 50 people infected. The January 2010 earthquake led to 
      the collapse of Haiti's social, economic and health infrastructure, exacerbating 
      social and structural HIV risk factors. Internally displaced (ID) women are
      particularly at high risk for HIV infection due to breakdown of community
      networks, increased poverty and sexual violence. The authors present the
      rationale and study protocol for pilot-testing FASY (Famn an Aksyon Pou Sante Yo)
      (Women Taking Action For Their Health), a psychoeducational HIV/STI prevention
      intervention with ID women in Haiti. METHODS AND ANALYSIS: This is a
      single-centre pragmatic N-of-1 pilot study. The target population is ID women in 
      Leogane, Haiti. The authors aim to recruit 200 participants using purposive
      peer-driven recruitment methods. ID women will be trained as community health
      workers to deliver the FASY intervention in Kreyol. Participants will conduct a
      pretest that involves an individual HIV/STI educational video-based component
      followed by a 6-week group programme of 2 h women's health meetings. The primary 
      outcome is HIV knowledge; our prespecified index of clinically significant change
      is an effect size of 0.30. Secondary outcomes include: sexually transmitted
      infections knowledge, condom use, social support, resilient coping, depression
      and relationship control. Multivariate analysis of variance will be used to
      compare pretest and post-test differences across variables to assess if the
      intervention influenced primary or secondary outcomes. Significant multivariate
      analysis of variance will be followed up with both univariate tests and
      discriminant function analyses to understand significant effects. ETHICS AND
      DISSEMINATION: Research Ethics Board approval (2011-0033-E) was attained from the
      Women's College Hospital, University of Toronto, Toronto, Ontario, Canada. Trial 
      results will be published according to the CONSORT statement, modified for the
      N-of-1 pilot study design, regardless of the outcomes. TRIAL REGISTRATION NUMBER:
      This study is registered at http://clinicaltrials.gov, registration number
      NCT01492829.
FAU - Logie, Carmen H
AU  - Logie CH
AD  - Faculty of Social Work, University of Calgary, Calgary, Alberta, Canada.
FAU - Daniel, Carolann
AU  - Daniel C
FAU - Newman, Peter A
AU  - Newman PA
FAU - Loutfy, Mona R
AU  - Loutfy MR
LA  - eng
SI  - ClinicalTrials.gov/NCT01492829
PT  - Journal Article
DEP - 20120718
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3401827
EDAT- 2012/07/21 06:00
MHDA- 2012/07/21 06:01
CRDT- 2012/07/21 06:00
PHST- 2012/07/21 06:00 [entrez]
PHST- 2012/07/21 06:00 [pubmed]
PHST- 2012/07/21 06:01 [medline]
AID - bmjopen-2012-001634 [pii]
AID - 10.1136/bmjopen-2012-001634 [doi]
PST - epublish
SO  - BMJ Open. 2012 Jul 18;2(4). pii: bmjopen-2012-001634. doi:
      10.1136/bmjopen-2012-001634. Print 2012.


PMID- 22814729
OWN - NLM
STAT- MEDLINE
DCOM- 20130108
LR  - 20120720
IS  - 1934-1563 (Electronic)
IS  - 1934-1482 (Linking)
VI  - 4
IP  - 7
DP  - 2012 Jul
TI  - Ethical challenges of caring for VIPs in the rehabilitation setting.
PG  - 517-20
LID - 10.1016/j.pmrj.2012.05.006 [doi]
FAU - Kirshblum, Steven
AU  - Kirshblum S
AD  - University of Medicine and Dentistry, New Jersey Medical School, Newark, NJ, USA.
FAU - Solomon, Gail M
AU  - Solomon GM
FAU - Brashler, Rebecca
AU  - Brashler R
FAU - Kirschner, Kristi L
AU  - Kirschner KL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - PM R
JT  - PM & R : the journal of injury, function, and rehabilitation
JID - 101491319
SB  - IM
MH  - Communication
MH  - *Ethics, Institutional
MH  - *Famous Persons
MH  - Humans
MH  - Patient Care Team
MH  - Privacy
MH  - Resource Allocation/ethics
MH  - Security Measures
EDAT- 2012/07/21 06:00
MHDA- 2013/01/09 06:00
CRDT- 2012/07/21 06:00
PHST- 2012/05/22 00:00 [received]
PHST- 2012/05/22 00:00 [accepted]
PHST- 2012/07/21 06:00 [entrez]
PHST- 2012/07/21 06:00 [pubmed]
PHST- 2013/01/09 06:00 [medline]
AID - S1934-1482(12)00260-2 [pii]
AID - 10.1016/j.pmrj.2012.05.006 [doi]
PST - ppublish
SO  - PM R. 2012 Jul;4(7):517-20. doi: 10.1016/j.pmrj.2012.05.006.


PMID- 22814660
OWN - NLM
STAT- MEDLINE
DCOM- 20121018
LR  - 20120720
IS  - 1532-6535 (Electronic)
IS  - 0009-9236 (Linking)
VI  - 92
IP  - 2
DP  - 2012 Aug
TI  - Ethical considerations in orphan drug approval and use.
PG  - 153-5
LID - 10.1038/clpt.2012.92 [doi]
AB  - The Orphan Drug Act seeks to meet a utilitarian goal of advancing therapeutic
      options for patients with rare diseases. However, data show that orphan drugs are
      often approved with more limited premarket testing than that carried out for
      nonorphan drugs and consequently expose patients to more risk and less certain
      efficacy. Therefore, the ethical principles of justice and beneficence may
      require attention to informed consent among patients receiving the drugs and
      greater investment in postmarket surveillance and confirmational testing.
FAU - Kesselheim, A S
AU  - Kesselheim AS
AD  - Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine,
      Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts,
      USA. akesselheim@partners.org
LA  - eng
GR  - K08HS18465-01/HS/AHRQ HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Clin Pharmacol Ther
JT  - Clinical pharmacology and therapeutics
JID - 0372741
SB  - IM
MH  - Clinical Trials as Topic
MH  - Drug Approval/*legislation & jurisprudence
MH  - Humans
MH  - Informed Consent
MH  - Orphan Drug Production/*ethics/legislation & jurisprudence/standards
MH  - Product Surveillance, Postmarketing/*standards
MH  - Rare Diseases/*drug therapy
MH  - Risk Assessment
EDAT- 2012/07/21 06:00
MHDA- 2012/10/19 06:00
CRDT- 2012/07/21 06:00
PHST- 2012/07/21 06:00 [entrez]
PHST- 2012/07/21 06:00 [pubmed]
PHST- 2012/10/19 06:00 [medline]
AID - clpt201292 [pii]
AID - 10.1038/clpt.2012.92 [doi]
PST - ppublish
SO  - Clin Pharmacol Ther. 2012 Aug;92(2):153-5. doi: 10.1038/clpt.2012.92.


PMID- 22814543
OWN - NLM
STAT- MEDLINE
DCOM- 20121130
LR  - 20140815
IS  - 1474-4465 (Electronic)
IS  - 1474-4422 (Linking)
VI  - 11
IP  - 8
DP  - 2012 Aug
TI  - Disorders of consciousness: responding to requests for novel diagnostic and
      therapeutic interventions.
PG  - 732-8
LID - 10.1016/S1474-4422(12)70154-0 [doi]
AB  - Severe brain injury can leave patients with chronic disorders of consciousness.
      Because of impaired responsiveness, many of these patients have traditionally
      been regarded as unaware. However, findings from recent clinical studies herald a
      potential paradigm shift: functional imaging and neurophysiological studies have 
      identified ways to assess awareness and have revealed astounding cases of
      awareness despite clinical unresponsiveness. Hence, diagnostic classifications
      have been rewritten, prognostic knowledge is improving, and therapeutic studies
      have regained momentum, showing for the first time some therapeutic effects on
      responsiveness. Clinicians must increasingly respond to requests by patients'
      families and surrogate decision makers to use novel techniques for diagnosis,
      prognosis, and treatment, and in doing so several ethical and social issues need 
      to be considered. Such requests provide an opportunity for clinicians to learn
      about patients' values and preferences and to maintain clinical acumen for
      changes in patient status with the patients' best interests in mind.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Jox, Ralf J
AU  - Jox RJ
AD  - Institute of Ethics, History and Theory of Medicine, University of Munich,
      Munich, Germany. ralf.jox@med.uni-muenchen.de
FAU - Bernat, James L
AU  - Bernat JL
FAU - Laureys, Steven
AU  - Laureys S
FAU - Racine, Eric
AU  - Racine E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Lancet Neurol
JT  - The Lancet. Neurology
JID - 101139309
SB  - IM
CIN - Lancet Neurol. 2012 Aug;11(8):657-8. PMID: 22814535
CIN - Lancet Neurol. 2013 Feb;12(2):131-2. PMID: 23260187
CIN - Lancet Neurol. 2013 Feb;12(2):132. PMID: 23260191
EIN - Lancet Neurol. 2012 Oct;11(10):841
MH  - *Attitude of Health Personnel
MH  - Consciousness Disorders/*diagnosis/*therapy
MH  - Decision Making/*ethics
MH  - Humans
MH  - Professional-Family Relations/*ethics
MH  - Prognosis
EDAT- 2012/07/21 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/21 06:00
PHST- 2012/07/21 06:00 [entrez]
PHST- 2012/07/21 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - S1474-4422(12)70154-0 [pii]
AID - 10.1016/S1474-4422(12)70154-0 [doi]
PST - ppublish
SO  - Lancet Neurol. 2012 Aug;11(8):732-8. doi: 10.1016/S1474-4422(12)70154-0.


PMID- 22813669
OWN - NLM
STAT- MEDLINE
DCOM- 20130516
LR  - 20160519
IS  - 1876-2026 (Electronic)
IS  - 1876-2018 (Linking)
VI  - 5
IP  - 2
DP  - 2012 Jun
TI  - Treating a physician patient with psychosis.
PG  - 193-8
LID - 10.1016/j.ajp.2012.03.001 [doi]
AB  - The authors present a case of a psychotic female patient who is a former graduate
      of a locally prestigious medical school and has subsequently been diagnosed with 
      schizophrenia. The patient entered treatment in an outpatient clinic following
      discharge from her 11th hospitalization. This hospitalization was initiated after
      the patient's physician friend had called the police and notified them that the
      patient was significantly disorganized to warrant further evaluation. Treatment
      was characterized by significant transference and counter-transference reactions 
      amongst her clinicians - both treatment-promoting and treatment-interfering -
      based on her status as a physician. The problem of insight was a significant
      hurdle in the treatment of the patient as her medical knowledge of mental illness
      was substantially greater than her insight into her own mental illness.
      Throughout treatment, a number of medical-legal and ethical issues arose.
      Initially, the question was raised as to the legality of the actions by the
      patient's friend-having made a clinical assessment without having a clinical role
      in the patient's care. As the patient's clinical status improved and she sought
      to re-enter the medical field as a resident, new medical legal issues surfaced.
      What were the roles of the patient's treaters in maintaining confidentiality and 
      simultaneously ensuring the safety of patients that the psychotic physician might
      care for? This case highlights the universality of psychiatric vulnerability.
      Insight in psychosis as well as the transference and counter-transference issues 
      involved in caring for a psychotic physician are discussed. Additionally, a
      thorough medical-legal discussion addresses the various complexities of caring
      for a psychotic physician.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Freedman, Jacob L
AU  - Freedman JL
AD  - Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA 02115,
      USA. jlfreedm@bidmc.harvard.edu
FAU - Crow, Fredrick F
AU  - Crow FF
FAU - Gutheil, Thomas G
AU  - Gutheil TG
FAU - Sanchez, Luis T
AU  - Sanchez LT
FAU - Suzuki, Joji
AU  - Suzuki J
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20120328
PL  - Netherlands
TA  - Asian J Psychiatr
JT  - Asian journal of psychiatry
JID - 101517820
SB  - IM
MH  - Adult
MH  - Female
MH  - Hospitalization/*legislation & jurisprudence
MH  - Humans
MH  - Physician-Patient Relations/*ethics
MH  - Physicians/*psychology
MH  - Psychotic Disorders/*psychology/therapy
EDAT- 2012/07/21 06:00
MHDA- 2013/05/17 06:00
CRDT- 2012/07/21 06:00
PHST- 2012/02/03 00:00 [received]
PHST- 2012/02/15 00:00 [revised]
PHST- 2012/03/02 00:00 [accepted]
PHST- 2012/07/21 06:00 [entrez]
PHST- 2012/07/21 06:00 [pubmed]
PHST- 2013/05/17 06:00 [medline]
AID - S1876-2018(12)00071-8 [pii]
AID - 10.1016/j.ajp.2012.03.001 [doi]
PST - ppublish
SO  - Asian J Psychiatr. 2012 Jun;5(2):193-8. doi: 10.1016/j.ajp.2012.03.001. Epub 2012
      Mar 28.


PMID- 22812719
OWN - NLM
STAT- MEDLINE
DCOM- 20121130
LR  - 20211021
IS  - 1749-6632 (Electronic)
IS  - 0077-8923 (Linking)
VI  - 1265
DP  - 2012 Aug
TI  - The ethics of research on deep brain stimulation for depression: decisional
      capacity and therapeutic misconception.
PG  - 69-79
LID - 10.1111/j.1749-6632.2012.06596.x [doi]
AB  - Research on deep brain stimulation (DBS) for treatment-resistant depression
      appears promising, but concerns have been raised about the decisional capacity of
      severely depressed patients and their potential misconceptions about the
      research. We assessed 31 DBS research participants with the MacArthur Competence 
      Assessment Tool for Clinical Research (MacCAT-CR), a well-validated capacity
      measure, and with a scale to measure therapeutic misconception, which occurs when
      subjects do not recognize key differences between treatment and clinical
      research. Correlations with baseline depressive symptoms were explored. Subjects'
      performance on the MacCAT-CR was excellent, but therapeutic misconception was
      still apparent. A trend toward significance was found in the correlation between 
      baseline depression ratings and total therapeutic misconception score. Responses 
      to open-ended prompts revealed both reassuring and concerning statements related 
      to expectations of risk, benefit, and individualization. Even severely depressed 
      patients did not manifest impairments in their capacity to consent to DBS
      research. Therapeutic misconception, however, remained prevalent.
CI  - (c) 2012 New York Academy of Sciences.
FAU - Fisher, Carl Erik
AU  - Fisher CE
AD  - Department of Psychiatry, College of Physicians & Surgeons, Columbia University, 
      New York, New York, USA.
FAU - Dunn, Laura B
AU  - Dunn LB
FAU - Christopher, Paul P
AU  - Christopher PP
FAU - Holtzheimer, Paul E
AU  - Holtzheimer PE
FAU - Leykin, Yan
AU  - Leykin Y
FAU - Mayberg, Helen S
AU  - Mayberg HS
FAU - Lisanby, Sarah H
AU  - Lisanby SH
FAU - Appelbaum, Paul S
AU  - Appelbaum PS
LA  - eng
SI  - ClinicalTrials.gov/NCT00367003
GR  - K23 MH077869/MH/NIMH NIH HHS/United States
GR  - K23 MH066062/MH/NIMH NIH HHS/United States
GR  - MH66062/MH/NIMH NIH HHS/United States
GR  - K08 MH091501/MH/NIMH NIH HHS/United States
GR  - MH091501/MH/NIMH NIH HHS/United States
GR  - MH077869/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120719
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Biomedical Research/*ethics
MH  - Decision Making/ethics
MH  - Deep Brain Stimulation/methods/*psychology
MH  - Depressive Disorder/*psychology/therapy
MH  - Female
MH  - Humans
MH  - Informed Consent/ethics
MH  - Male
MH  - Mental Competency
MH  - Middle Aged
MH  - Surveys and Questionnaires
MH  - Therapeutic Misconception/ethics/psychology
MH  - Young Adult
PMC - PMC3624886
MID - NIHMS453897
EDAT- 2012/07/21 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/21 06:00
PHST- 2012/07/21 06:00 [entrez]
PHST- 2012/07/21 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1111/j.1749-6632.2012.06596.x [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2012 Aug;1265:69-79. doi: 10.1111/j.1749-6632.2012.06596.x.
      Epub 2012 Jul 19.


PMID- 22812400
OWN - NLM
STAT- MEDLINE
DCOM- 20121015
LR  - 20220316
IS  - 1471-2431 (Electronic)
IS  - 1471-2431 (Linking)
VI  - 12
DP  - 2012 Jul 19
TI  - Paracetamol use (and/or misuse) in children in Enugu, South-East, Nigeria.
PG  - 103
LID - 10.1186/1471-2431-12-103 [doi]
AB  - BACKGROUND: Paracetamol (also known as acetaminophen) is the commonest available 
      analgesic and anti-pyretic. It is readily accessed from pharmacy, patent medicine
      and provision shops as over the counter drug making it a potential drug of abuse,
      especially in children. We sought to find its use and/or misuse in children seen 
      at the paediatric outpatient clinic of the University of Nigeria Teaching
      Hospital (UNTH) Ituku-Ozalla, Enugu. OBJECTIVE: To determine the dosage,
      formulation, and frequency of paracetamol administration to children by
      caregivers and factors associated with its use and/or misuse. METHOD: An
      observational prospective study involving 231 children and their caregivers seen 
      at the paediatric outpatient clinic of the University of Nigeria Teaching
      Hospital, Ituku - Ozalla, Enugu between June and November 2011 was undertaken.
      Data on paracetamol use before presentation to the clinic, in addition to
      demographic and other data were obtained from the caregivers using a structured
      questionnaire. Ethical consent for the study was obtained from the Hospital
      Ethics and Research Committee and informed consent was further obtained from the 
      caregivers of the children. RESULTS: A total of 231 children aged six weeks to 16
      years and their caregivers participated in this study. The mean ages of the
      children and their caregivers were 3.8 and 33.9 years, respectively. One hundred 
      and thirty three of the children studied were males while 98 were females. Most
      of the children (75.6%) received paracetamol at home before presenting.
      Paracetamol tablet alone or in combination with the syrup was mostly used (60%)
      and this observation was made across all age groups. The commonest reason for
      using paracetamol tablet instead of the syrup was that it was more effective.
      Most caregivers relied on past experience (71.2%) rather than on enclosed
      information leaflet to decide the appropriate dosage. Half of the children also
      received other medications, mainly anti-malarials and antibiotics. CONCLUSIONS:
      Paracetamol was commonly given to children on "self prescription" basis and the
      tablet formulation was most frequently used, with the possibility of misuse and
      overdose. Caregivers need to be educated on age-appropriate formulations which
      are less likely to lead to overdose.
FAU - Obu, Herbert A
AU  - Obu HA
AD  - Department of Paediatrics, College of Medicine, University of Nigeria, Enugu
      Campus & University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu 400001,
      Nigeria. herbert.obu@unn.edu.ng
FAU - Chinawa, Josephat M
AU  - Chinawa JM
FAU - Ubesie, Agozie C
AU  - Ubesie AC
FAU - Eke, Christopher B
AU  - Eke CB
FAU - Ndu, Ikenna K
AU  - Ndu IK
LA  - eng
PT  - Journal Article
DEP - 20120719
PL  - England
TA  - BMC Pediatr
JT  - BMC pediatrics
JID - 100967804
RN  - 0 (Analgesics, Non-Narcotic)
RN  - 0 (Pharmaceutical Solutions)
RN  - 0 (Tablets)
RN  - 362O9ITL9D (Acetaminophen)
SB  - IM
MH  - *Acetaminophen/administration & dosage/therapeutic use
MH  - Adolescent
MH  - Adult
MH  - *Analgesics, Non-Narcotic/administration & dosage/therapeutic use
MH  - Caregivers
MH  - Child
MH  - Child, Preschool
MH  - Drug Utilization/*statistics & numerical data
MH  - Female
MH  - Fever/drug therapy
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Infant
MH  - Male
MH  - Middle Aged
MH  - Nigeria
MH  - Pain/drug therapy
MH  - Pharmaceutical Solutions
MH  - Prospective Studies
MH  - Self Medication/*statistics & numerical data
MH  - Surveys and Questionnaires
MH  - Tablets
PMC - PMC3411451
EDAT- 2012/07/21 06:00
MHDA- 2012/10/16 06:00
CRDT- 2012/07/21 06:00
PHST- 2012/03/08 00:00 [received]
PHST- 2012/07/19 00:00 [accepted]
PHST- 2012/07/21 06:00 [entrez]
PHST- 2012/07/21 06:00 [pubmed]
PHST- 2012/10/16 06:00 [medline]
AID - 1471-2431-12-103 [pii]
AID - 10.1186/1471-2431-12-103 [doi]
PST - epublish
SO  - BMC Pediatr. 2012 Jul 19;12:103. doi: 10.1186/1471-2431-12-103.


PMID- 22812183
OWN - NLM
STAT- MEDLINE
DCOM- 20120828
LR  - 20120719
IS  - 0300-9041 (Print)
IS  - 0300-9041 (Linking)
VI  - 80
IP  - 3
DP  - 2012 Mar
TI  - [Some ethical problems in obstetrics and gynecology. 1957].
PG  - 241-9
FAU - Sordo Noriega, Antonio
AU  - Sordo Noriega A
LA  - spa
PT  - Biography
PT  - Classical Article
PT  - Historical Article
PT  - Journal Article
TT  - Algunos problemas de etica en gineco-obstetricia.
PL  - Mexico
TA  - Ginecol Obstet Mex
JT  - Ginecologia y obstetricia de Mexico
JID - 0376552
SB  - IM
MH  - Abortion, Induced/ethics/history
MH  - Beginning of Human Life
MH  - Contraception/ethics/history
MH  - Female
MH  - Gynecology/ethics/*history
MH  - History, 20th Century
MH  - Humans
MH  - Labor, Induced/ethics/history
MH  - Obstetrics/ethics/*history
MH  - Pregnancy
MH  - Pregnancy Complications, Neoplastic/therapy
MH  - Reproductive Techniques, Assisted/ethics/history
PS  - Sordo Noriega A
FPS - Sordo Noriega, Antonio
EDAT- 2012/07/21 06:00
MHDA- 2012/08/29 06:00
CRDT- 2012/07/21 06:00
PHST- 2012/07/21 06:00 [entrez]
PHST- 2012/07/21 06:00 [pubmed]
PHST- 2012/08/29 06:00 [medline]
PST - ppublish
SO  - Ginecol Obstet Mex. 2012 Mar;80(3):241-9.


PMID- 22811556
OWN - NLM
STAT- MEDLINE
DCOM- 20130108
LR  - 20151119
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 11
DP  - 2012 Nov
TI  - Palliative sedation: not just normal medical practice. Ethical reflections on the
      Royal Dutch Medical Association's guideline on palliative sedation.
PG  - 664-8
LID - 10.1136/medethics-2011-100353 [doi]
AB  - The main premise of the Royal Dutch Medical Association's (RDMA) guideline on
      palliative sedation is that palliative sedation, contrary to euthanasia, is
      normal medical practice. Although we do not deny the ethical distinctions between
      euthanasia and palliative sedation, we will critically analyse the guideline's
      argumentation strategy with which euthanasia is demarcated from palliative
      sedation. First, we will analyse the guideline's main premise, which entails that
      palliative sedation is normal medical treatment. After this, we will critically
      discuss three crucial propositions of the guideline that are used to support this
      premise: (1) the patient's life expectancy should not exceed 2 weeks; (2) the aim
      of the physician should be to relieve suffering and (3) expert consultation is
      optional. We will conclude that, if inherent problematic aspects of palliative
      sedation are taken seriously, palliative sedation is less normal than it is now
      depicted in the guideline.
FAU - Janssens, Rien
AU  - Janssens R
AD  - Department of Medical Humanities, EMGO Institute for Health and Care Research, VU
      University Medical Center, Amsterdam, Netherlands. mjpa.janssens@vumc.nl
FAU - van Delden, Johannes J M
AU  - van Delden JJ
FAU - Widdershoven, Guy A M
AU  - Widdershoven GA
LA  - eng
PT  - Journal Article
DEP - 20120718
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
RN  - 0 (Analgesics, Opioid)
SB  - IM
MH  - Analgesics, Opioid/administration & dosage
MH  - Conscious Sedation/ethics
MH  - Consciousness/drug effects
MH  - Deep Sedation/*ethics
MH  - *Double Effect Principle
MH  - Ethical Analysis
MH  - Euthanasia, Passive/ethics
MH  - Humans
MH  - Intention
MH  - Life Expectancy
MH  - Netherlands
MH  - Palliative Care/*ethics
MH  - Patient Care Planning/*ethics/standards/trends
MH  - *Practice Guidelines as Topic/standards
MH  - Practice Patterns, Physicians'/*ethics/standards/trends
MH  - Referral and Consultation
MH  - Societies, Medical
MH  - Stress, Psychological/*prevention & control
MH  - Terminal Care/*ethics
MH  - Time Factors
EDAT- 2012/07/20 06:00
MHDA- 2013/01/09 06:00
CRDT- 2012/07/20 06:00
PHST- 2012/07/20 06:00 [entrez]
PHST- 2012/07/20 06:00 [pubmed]
PHST- 2013/01/09 06:00 [medline]
AID - medethics-2011-100353 [pii]
AID - 10.1136/medethics-2011-100353 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Nov;38(11):664-8. doi: 10.1136/medethics-2011-100353. Epub
      2012 Jul 18.


PMID- 22811382
OWN - NLM
STAT- MEDLINE
DCOM- 20121119
LR  - 20171116
IS  - 1098-240X (Electronic)
IS  - 0160-6891 (Linking)
VI  - 35
IP  - 5
DP  - 2012 Oct
TI  - Authorship ethics with the dissertation manuscript option.
PG  - 431-4
LID - 10.1002/nur.21500 [doi]
FAU - Gross, Deborah
AU  - Gross D
FAU - Alhusen, Jeanne
AU  - Alhusen J
FAU - Jennings, Bonnie Mowinski
AU  - Jennings BM
LA  - eng
PT  - Editorial
DEP - 20120718
PL  - United States
TA  - Res Nurs Health
JT  - Research in nursing & health
JID - 7806136
SB  - IM
MH  - *Academic Dissertations as Topic/standards
MH  - *Authorship/standards
MH  - Faculty
MH  - Humans
MH  - *Scientific Misconduct
MH  - Students
EDAT- 2012/07/20 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/20 06:00
PHST- 2012/07/20 06:00 [entrez]
PHST- 2012/07/20 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1002/nur.21500 [doi]
PST - ppublish
SO  - Res Nurs Health. 2012 Oct;35(5):431-4. doi: 10.1002/nur.21500. Epub 2012 Jul 18.


PMID- 22811377
OWN - NLM
STAT- MEDLINE
DCOM- 20120913
LR  - 20220408
IS  - 0300-9831 (Print)
IS  - 0300-9831 (Linking)
VI  - 82
IP  - 1
DP  - 2012 Feb
TI  - The relationship between vitamin D and severe early childhood caries: a pilot
      study.
PG  - 53-62
LID - 10.1024/0300-9831/a000094 [doi]
AB  - INTRODUCTION: Children with Severe Early Childhood Caries (S-ECC) routinely
      require dental surgery. S-ECC is known to affect childhood health and well-being.
      The objective of this pilot study was to assess vitamin D [25(OH)D] levels and
      determine whether differences exist between children with and without S-ECC.
      METHODS: During July-September 2008, children undergoing surgery for S-ECC < 72
      months of age from southern Manitoba were recruited. Age-matched controls were
      caries-free. Parents completed an interviewed questionnaire. A serum sample was
      obtained for 25(OH)D and parathyroid hormone (PTH) levels. This study was
      approved by the University of Manitoba's Ethics Board. Statistics included
      chi-square analysis, t-tests, and multiple and logistic regression. A p value of 
      <= 0.05 was significant. RESULTS: Thirty-eight children participated (50 % with
      S-ECC). There was no significant age difference between groups (p = 0.82). The
      majority of the entire sample (84.2 %) had inadequate vitamin D levels. Children 
      with S-ECC had lower concentrations of 25(OH)D (52.9 +/- 15.1 nmol/L vs. 64.4 +/-
      21.3, p = 0.032) and were at twice the odds of having inadequate levels (<75
      nmol/L). Children with S-ECC also had significantly higher PTH levels than
      caries-free children (53.5 +/- 17.6 cm/L vs. 33.9 +/- 12.9, p < 0.001). A greater
      number with S-ECC had elevated PTH levels (68.4 % vs. 21.1 %, p < 0.01).
      CONCLUSIONS: This pilot study is the first to report differences in 25(OH)D
      between those with S-ECC and cavity-free controls. Children with S-ECC have lower
      vitamin D levels and increased PTH levels compared to age-matched controls.
FAU - Schroth, Robert J
AU  - Schroth RJ
AD  - University of Manitoba, Winnipeg, Canada. umschrot@cc.umanitoba.ca
FAU - Jeal, Nathan S
AU  - Jeal NS
FAU - Kliewer, Eleonore
AU  - Kliewer E
FAU - Sellers, Elizabeth A C
AU  - Sellers EA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Int J Vitam Nutr Res
JT  - International journal for vitamin and nutrition research. Internationale
      Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de
      vitaminologie et de nutrition
JID - 1273304
RN  - 0 (Parathyroid Hormone)
RN  - 1406-16-2 (Vitamin D)
RN  - A288AR3C9H (25-hydroxyvitamin D)
SB  - IM
MH  - Child, Preschool
MH  - Dental Caries/blood/*etiology
MH  - Female
MH  - Humans
MH  - Infant
MH  - Logistic Models
MH  - Male
MH  - Parathyroid Hormone/blood
MH  - Pilot Projects
MH  - Social Class
MH  - Vitamin D/*analogs & derivatives/blood
EDAT- 2012/07/20 06:00
MHDA- 2012/09/14 06:00
CRDT- 2012/07/20 06:00
PHST- 2012/07/20 06:00 [entrez]
PHST- 2012/07/20 06:00 [pubmed]
PHST- 2012/09/14 06:00 [medline]
AID - 10.1024/0300-9831/a000094 [doi]
PST - ppublish
SO  - Int J Vitam Nutr Res. 2012 Feb;82(1):53-62. doi: 10.1024/0300-9831/a000094.


PMID- 22811214
OWN - NLM
STAT- MEDLINE
DCOM- 20140624
LR  - 20130806
IS  - 1938-2715 (Electronic)
IS  - 1049-9091 (Linking)
VI  - 30
IP  - 5
DP  - 2013 Aug
TI  - Providing quality palliative care in end-stage Alzheimer disease.
PG  - 499-502
LID - 10.1177/1049909112453644 [doi]
AB  - Providing quality palliative care is a daunting task profoundly impacted by
      diminished patient capacity at the end of life. Alzheimer disease (AD) is a
      disorder that erases our memories and is projected to increase dramatically for
      decades to come. By the time the patients with AD reach the end stage of the
      disease, the ability of patients to provide pertinent subjective complaints of
      pain and discomfort would have vanished. Historical perspectives of palliative
      care, exploration of the AD process, ethical issues, and crucial clinical
      considerations are provided to improve the understanding of disease progression
      and quality of care for patients with end-stage AD.
FAU - Yeaman, Paul A
AU  - Yeaman PA
AD  - Salem Veterans Affairs Medical Center, Jefferson College of Health Sciences, VA, 
      USA.
FAU - Ford, James L
AU  - Ford JL
FAU - Kim, Kye Y
AU  - Kim KY
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120718
PL  - United States
TA  - Am J Hosp Palliat Care
JT  - The American journal of hospice & palliative care
JID - 9008229
SB  - IM
MH  - Alzheimer Disease/*therapy
MH  - Humans
MH  - Pain Management/methods
MH  - Palliative Care/ethics/methods/*standards
MH  - Quality of Health Care/ethics
MH  - Terminal Care/ethics/methods/*standards
OTO - NOTNLM
OT  - Alzheimer disease
OT  - clinical issues
OT  - end stage
OT  - ethical issues
OT  - palliative care
OT  - quality
EDAT- 2012/07/20 06:00
MHDA- 2014/06/25 06:00
CRDT- 2012/07/20 06:00
PHST- 2012/07/20 06:00 [entrez]
PHST- 2012/07/20 06:00 [pubmed]
PHST- 2014/06/25 06:00 [medline]
AID - 1049909112453644 [pii]
AID - 10.1177/1049909112453644 [doi]
PST - ppublish
SO  - Am J Hosp Palliat Care. 2013 Aug;30(5):499-502. doi: 10.1177/1049909112453644.
      Epub 2012 Jul 18.


PMID- 22811051
OWN - NLM
STAT- MEDLINE
DCOM- 20160824
LR  - 20181201
IS  - 0303-7339 (Print)
IS  - 0303-7339 (Linking)
VI  - 54
IP  - 7
DP  - 2012
TI  - [Autonomy: to what extent is the concept relevant in psychiatry?].
PG  - 393-402
AB  - BACKGROUND: Autonomy is an important concept in psychiatry, but because it is a
      somewhat abstract and ambiguous notion, it is not applicable in its entirety in a
      psychiatric context. This becomes obvious in situations where patients are
      receiving long term care and treatment. AIM: To modify the concept of autonomy in
      such a way that it acquires an extra dimension that renders it applicable to
      daily psychiatric practice. METHOD: The literature was reviewed in order to find 
      articles that reveal the tensions that arise between autonomy and dependence in
      psychiatry and that reflect the human characteristics that are concealed behind
      the modern concepts of autonomy, freedom and respect for autonomy. RESULTS:
      Concepts such as person, identity, acknowledgement, dialogical ethics and life
      histories are used as an addition to the concepts of autonomy of Kant and Mill. A
      phenomenological and a context sensitive conception of autonomy is needed within 
      the perspective of dialogical ethics. A dialogical perspective requires from
      psychiatric professionals a susceptibility for what the patient as a human being 
      really has to say. On the basis of a dialogue where there is space and attention 
      for life histories, backgrounds and the potentials of patients, a new perspective
      can be developed that is shared by the persons involved. CONCLUSION: In
      psychiatry, statements about real autonomy and genuine respect for autonomy are
      only truly meaningful within the context of doctors, nurses and patients. A
      hermeneutic approach to patients which involves dialogue creates new
      opportunities in the field of staff-patient relations.
FAU - de Wit, F A
AU  - de Wit FA
AD  - fadewit@xs4all.nl
LA  - dut
PT  - Journal Article
PT  - Comment
TT  - Autonomie: een zorgelijk begrip?
PL  - Netherlands
TA  - Tijdschr Psychiatr
JT  - Tijdschrift voor psychiatrie
JID - 0423731
SB  - IM
CON - Tijdschr Psychiatr. 2012;54(8):770
EIN - Tijdschr Psychiatr. 2012;54(8):770
MH  - Humans
MH  - *Personal Autonomy
MH  - Psychiatry/*ethics
EDAT- 2012/07/20 06:00
MHDA- 2016/08/25 06:00
CRDT- 2012/07/20 06:00
PHST- 2012/07/20 06:00 [entrez]
PHST- 2012/07/20 06:00 [pubmed]
PHST- 2016/08/25 06:00 [medline]
AID - TVPart_9413 [pii]
PST - ppublish
SO  - Tijdschr Psychiatr. 2012;54(7):393-402.


PMID- 22811029
OWN - NLM
STAT- MEDLINE
DCOM- 20130416
LR  - 20121018
IS  - 1530-0315 (Electronic)
IS  - 0195-9131 (Linking)
VI  - 44
IP  - 11
DP  - 2012 Nov
TI  - ACSM and CHAMP summit on sickle cell trait: mitigating risks for warfighters and 
      athletes.
PG  - 2045-56
LID - 10.1249/MSS.0b013e31826851c2 [doi]
AB  - INTRODUCTION: An estimated 300 million people worldwide have sickle cell trait
      (SCT). Although largely benign, SCT has been associated with exertional
      rhabdomyolysis and exercise-related sudden death in warfighters/athletes (WA).
      The National Collegiate Athletic Association's policy to confirm a student
      athlete's SCT status during their preparticipation medical examination prompted
      reaction from some organizations regarding the rationale and ethical
      justification of the policy. METHODS: On September 26 and 27, 2011, a summit,
      composed of military and civilian experts in sports medicine and SCT, was
      convened at the Uniformed Services University in Bethesda, MD. The expert panel
      was charged with two objectives: 1) to provide specific recommendations to
      further mitigate the apparent risk with strenuous exercise in WA with SCT and 2) 
      to develop clinical guidelines to identify, treat, and return to duty/play WA
      suspected to have incurred nonfatal sickle cell collapse. RESULTS: New
      terminology is introduced, areas of current controversy are explored, consensus
      recommendations for mitigating risk and managing the WA with SCT are reviewed,
      and important areas for future research are identified. CONCLUSION: Further
      research is needed before conclusions can be drawn regarding the etiology of the 
      increased death rate observed in WA with SCT, and the possibility exists that SCT
      is a surrogate for as yet another contributing factor for the unexplained deaths.
FAU - O'Connor, Francis G
AU  - O'Connor FG
AD  - Department of Military and Emergency Medicine, Uniformed Services University of
      the Health Sciences, Bethesda, MD, USA. francis.oconnor@usuhs.edu
FAU - Bergeron, Michael F
AU  - Bergeron MF
FAU - Cantrell, Joyce
AU  - Cantrell J
FAU - Connes, Philippe
AU  - Connes P
FAU - Harmon, Kimberly G
AU  - Harmon KG
FAU - Ivy, Edward
AU  - Ivy E
FAU - Kark, John
AU  - Kark J
FAU - Klossner, Dave
AU  - Klossner D
FAU - Lisman, Peter
AU  - Lisman P
FAU - Meyers, Bryce K
AU  - Meyers BK
FAU - O'Brien, Karen
AU  - O'Brien K
FAU - Ohene-Frempong, Kwaku
AU  - Ohene-Frempong K
FAU - Thompson, Alexis A
AU  - Thompson AA
FAU - Whitehead, James
AU  - Whitehead J
FAU - Deuster, Patricia A
AU  - Deuster PA
LA  - eng
PT  - Consensus Development Conference
PT  - Guideline
PT  - Journal Article
PL  - United States
TA  - Med Sci Sports Exerc
JT  - Medicine and science in sports and exercise
JID - 8005433
SB  - IM
MH  - *Athletes
MH  - Athletic Performance
MH  - Death, Sudden/etiology/*prevention & control
MH  - Female
MH  - Humans
MH  - Male
MH  - *Military Personnel
MH  - Physical Exertion/physiology
MH  - *Risk Reduction Behavior
MH  - Schools, Medical
MH  - Sickle Cell Trait/*complications/diagnosis
MH  - United States
EDAT- 2012/07/20 06:00
MHDA- 2013/04/17 06:00
CRDT- 2012/07/20 06:00
PHST- 2012/07/20 06:00 [entrez]
PHST- 2012/07/20 06:00 [pubmed]
PHST- 2013/04/17 06:00 [medline]
AID - 10.1249/MSS.0b013e31826851c2 [doi]
PST - ppublish
SO  - Med Sci Sports Exerc. 2012 Nov;44(11):2045-56. doi: 10.1249/MSS.0b013e31826851c2.


PMID- 22810581
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20211021
IS  - 1573-0980 (Electronic)
IS  - 1386-7415 (Linking)
VI  - 33
IP  - 4
DP  - 2012 Aug
TI  - Where should we draw the line between quality of care and other ethical concerns 
      related to medical registries and biobanks?
PG  - 313-23
LID - 10.1007/s11017-012-9229-x [doi]
AB  - Together with large biobanks of human samples, medical registries with aggregated
      data from many clinical centers are vital parts of an infrastructure for
      maintaining high standards of quality with regard to medical diagnosis and
      treatment. The rapid development in personalized medicine and pharmaco-genomics
      only underscores the future need for these infrastructures. However, registries
      and biobanks have been criticized as constituting great risks to individual
      privacy. In this article, I suggest that quality with regard to diagnosis and
      treatment is an inherent, morally normative requirement of health care, and argue
      that quality concerns in this sense may be balanced with privacy concerns.
FAU - Hansson, Mats
AU  - Hansson M
AD  - Department of Public Health and Caring Sciences, Centre for Research Ethics &
      Bioethics, Uppsala University, P.O. Box 564, 751 22, Uppsala, Sweden.
      Mats.Hansson@crb.uu.se
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Theor Med Bioeth
JT  - Theoretical medicine and bioethics
JID - 9805378
SB  - IM
MH  - Access to Information
MH  - Bioethics
MH  - Humans
MH  - Informed Consent/ethics
MH  - *Privacy
MH  - *Quality of Health Care
MH  - *Registries/ethics/standards
MH  - *Tissue Banks/ethics/standards
MH  - United States
EDAT- 2012/07/20 06:00
MHDA- 2012/11/14 06:00
CRDT- 2012/07/20 06:00
PHST- 2012/07/20 06:00 [entrez]
PHST- 2012/07/20 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
AID - 10.1007/s11017-012-9229-x [doi]
PST - ppublish
SO  - Theor Med Bioeth. 2012 Aug;33(4):313-23. doi: 10.1007/s11017-012-9229-x.


PMID- 22810254
OWN - NLM
STAT- MEDLINE
DCOM- 20120830
LR  - 20211021
IS  - 1080-2371 (Print)
IS  - 1080-2371 (Linking)
VI  - 18
IP  - 3
DP  - 2012 Jun
TI  - Surrogate decision making in neurocritical care.
PG  - 655-8
LID - 10.1212/01.CON.0000415433.91771.55 [doi]
AB  - Patients with critical neurologic illness typically have impaired capacity to
      make their own medical decisions. In these cases, neurologists need to make
      medical decisions based on advance directives (such as a living will) or the
      decisions of a surrogate. A hypothetical case of a 60-year-old man with an
      intracerebral hemorrhage is used to highlight some of the difficulties that can
      occur when attempting to apply general statements made in a living will to a
      specific medical treatment decision. The ethical and legal issues surrounding
      surrogate decision making as they apply to acute critical neurologic disease are 
      discussed, along with suggestions for how to resolve potential disagreements.
FAU - Adelman, Eric E
AU  - Adelman EE
AD  - Department of Neurology, University of Michigan, Cardiovascular Center, Room
      3392, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA.
FAU - Zahuranec, Darin B
AU  - Zahuranec DB
LA  - eng
GR  - K23 AG038731/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Continuum (Minneap Minn)
JT  - Continuum (Minneapolis, Minn.)
JID - 9509333
SB  - IM
MH  - Brain Diseases/*psychology/therapy
MH  - *Critical Care/ethics/legislation & jurisprudence
MH  - *Decision Making/ethics
MH  - Emotions
MH  - Family Relations
MH  - Humans
MH  - Informed Consent
MH  - Living Wills
MH  - *Mental Competency
MH  - Negotiating
MH  - Patient Preference
MH  - Personal Autonomy
MH  - Professional-Family Relations
MH  - *Third-Party Consent/ethics/legislation & jurisprudence
PMC - PMC3915599
EDAT- 2012/07/20 06:00
MHDA- 2012/08/31 06:00
CRDT- 2012/07/20 06:00
PHST- 2012/07/20 06:00 [entrez]
PHST- 2012/07/20 06:00 [pubmed]
PHST- 2012/08/31 06:00 [medline]
AID - 10.1212/01.CON.0000415433.91771.55 [doi]
AID - 00132979-201206000-00014 [pii]
PST - ppublish
SO  - Continuum (Minneap Minn). 2012 Jun;18(3):655-8. doi:
      10.1212/01.CON.0000415433.91771.55.


PMID- 22810076
OWN - NLM
STAT- MEDLINE
DCOM- 20120822
LR  - 20151119
IS  - 1080-2371 (Print)
IS  - 1080-2371 (Linking)
VI  - 18
IP  - 1
DP  - 2012 Feb
TI  - Opioid administration for severe neuropathic pain in a patient with depression
      and prior heroin use.
PG  - 176-80
LID - 10.1212/01.CON.0000411563.41709.e3 [doi]
AB  - The treatment of pain can raise ethical dilemmas. This article presents a case of
      a young woman with a pain crisis from severe neuropathic pain that is complicated
      by comorbidities of depression and prior (but not active) heroin use. Medical and
      ethical justifications for either withholding or providing opioids for her pain
      are examined. State and federal laws governing opioid prescriptions by physicians
      for pain management are reviewed.
FAU - Elliott, Kathryn J
AU  - Elliott KJ
AD  - Mount Sinai Medical School, New York, New York, USA. kathryn.elliott@mssm.edu
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Continuum (Minneap Minn)
JT  - Continuum (Minneapolis, Minn.)
JID - 9509333
RN  - 0 (Analgesics, Opioid)
SB  - IM
MH  - Adult
MH  - Analgesics, Opioid/*therapeutic use
MH  - Comorbidity
MH  - Depression/complications/epidemiology
MH  - Female
MH  - HIV Infections/complications/epidemiology
MH  - Heroin Dependence/complications/epidemiology
MH  - Humans
MH  - Neuralgia/complications/*drug therapy/epidemiology
MH  - Practice Patterns, Physicians'/*ethics
EDAT- 2012/07/20 06:00
MHDA- 2012/08/23 06:00
CRDT- 2012/07/20 06:00
PHST- 2012/07/20 06:00 [entrez]
PHST- 2012/07/20 06:00 [pubmed]
PHST- 2012/08/23 06:00 [medline]
AID - 10.1212/01.CON.0000411563.41709.e3 [doi]
AID - 00132979-201202000-00014 [pii]
PST - ppublish
SO  - Continuum (Minneap Minn). 2012 Feb;18(1):176-80. doi:
      10.1212/01.CON.0000411563.41709.e3.


PMID- 22809836
OWN - NLM
STAT- MEDLINE
DCOM- 20120926
LR  - 20181023
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 345
DP  - 2012 Jul 18
TI  - Prenatal blood test for Down's syndrome is to be introduced in Germany despite
      ethical and legal concerns.
PG  - e4836
LID - 10.1136/bmj.e4836 [doi]
LID - bmj.e4836 [pii]
FAU - Tuffs, Annette
AU  - Tuffs A
LA  - eng
PT  - News
DEP - 20120718
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
SB  - IM
MH  - Down Syndrome/blood/*diagnosis
MH  - Female
MH  - Genetic Testing/ethics/*legislation & jurisprudence
MH  - Germany
MH  - Humans
MH  - Pregnancy
MH  - Prenatal Diagnosis/*ethics
EDAT- 2012/07/20 06:00
MHDA- 2012/09/27 06:00
CRDT- 2012/07/20 06:00
PHST- 2012/07/20 06:00 [entrez]
PHST- 2012/07/20 06:00 [pubmed]
PHST- 2012/09/27 06:00 [medline]
AID - 10.1136/bmj.e4836 [doi]
PST - epublish
SO  - BMJ. 2012 Jul 18;345:e4836. doi: 10.1136/bmj.e4836.


PMID- 22809073
OWN - NLM
STAT- MEDLINE
DCOM- 20120830
LR  - 20120719
IS  - 1944-7515 (Print)
IS  - 1944-7558 (Linking)
VI  - 117
IP  - 4
DP  - 2012 Jul
TI  - "We want respect": adults with intellectual and developmental disabilities
      address respect in research.
PG  - 263-74
LID - 10.1352/1944-7558-117.4.263 [doi]
AB  - Respect is central to ethical guidelines for research. The scientific community
      has long debated, and at times disagreed on, how to demonstrate respect in
      research with adults with intellectual and developmental disabilities. To
      illuminate the voices of those most affected, the author studies the views of
      adults with intellectual and developmental disabilities on respect in research.
      Findings are consistent with disability rights' ideas and indicate that adults
      with intellectual and developmental disabilities have much to contribute to the
      discussion, that they value participating, and that they agree with calls to
      focus on human rights and dignity. Notably, participants spoke at lengths about
      the nature of interactions between researchers and participants. Implications are
      discussed, including how to infuse research standards with community-supported
      values and preferences.
FAU - McDonald, Katherine Elizabeth
AU  - McDonald KE
AD  - Public Health, Food Studies, and Nutrition and the Burton Blatt Institute,
      Syracuse University, Syracuse, NY 13244, USA. kemcdona@syr.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Intellect Dev Disabil
JT  - American journal on intellectual and developmental disabilities
JID - 101492916
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Biomedical Research/ethics/standards
MH  - Developmental Disabilities/*psychology
MH  - Female
MH  - Humans
MH  - Intellectual Disability/*psychology
MH  - Interview, Psychological
MH  - Male
MH  - Middle Aged
MH  - Patient Participation/*psychology
MH  - Professional-Patient Relations/*ethics
MH  - Qualitative Research
MH  - Research Design/*standards
MH  - Young Adult
EDAT- 2012/07/20 06:00
MHDA- 2012/08/31 06:00
CRDT- 2012/07/20 06:00
PHST- 2012/07/20 06:00 [entrez]
PHST- 2012/07/20 06:00 [pubmed]
PHST- 2012/08/31 06:00 [medline]
AID - 10.1352/1944-7558-117.4.263 [doi]
PST - ppublish
SO  - Am J Intellect Dev Disabil. 2012 Jul;117(4):263-74. doi:
      10.1352/1944-7558-117.4.263.


PMID- 22808944
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121113
LR  - 20220410
IS  - 1478-7547 (Electronic)
IS  - 1478-7547 (Linking)
VI  - 10
IP  - 1
DP  - 2012 Jul 18
TI  - From efficacy to equity: Literature review of decision criteria for resource
      allocation and healthcare decisionmaking.
PG  - 9
LID - 10.1186/1478-7547-10-9 [doi]
AB  - UNLABELLED: OBJECTIVES: Resource allocation is a challenging issue faced by
      health policy decisionmakers requiring careful consideration of many factors.
      Objectives of this study were to identify decision criteria and their frequency
      reported in the literature on healthcare decisionmaking. METHOD: An extensive
      literature search was performed in Medline and EMBASE to identify articles
      reporting healthcare decision criteria. Studies conducted with decisionmakers
      (e.g., focus groups, surveys, interviews), conceptual and review articles and
      articles describing multicriteria tools were included. Criteria were extracted,
      organized using a classification system derived from the EVIDEM framework and
      applying multicriteria decision analysis (MCDA) principles, and the frequency of 
      their occurrence was measured. RESULTS: Out of 3146 records identified, 2790 were
      excluded. Out of 356 articles assessed for eligibility, 40 studies included.
      Criteria were identified from studies performed in several regions of the world
      involving decisionmakers at micro, meso and macro levels of decision and from
      studies reporting on multicriteria tools. Large variations in terminology used to
      define criteria were observed and 360 different terms were identified. These were
      assigned to 58 criteria which were classified in 9 different categories
      including: health outcomes; types of benefit; disease impact; therapeutic
      context; economic impact; quality of evidence; implementation complexity;
      priority, fairness and ethics; and overall context. The most frequently mentioned
      criteria were: equity/fairness (32 times), efficacy/effectiveness (29),
      stakeholder interests and pressures (28), cost-effectiveness (23), strength of
      evidence (20), safety (19), mission and mandate of health system (19),
      organizational requirements and capacity (17), patient-reported outcomes (17) and
      need (16). CONCLUSION: This study highlights the importance of considering both
      normative and feasibility criteria for fair allocation of resources and optimized
      decisionmaking for coverage and use of healthcare interventions. This analysis
      provides a foundation to develop a questionnaire for an international survey of
      decisionmakers on criteria and their relative importance. The ultimate objective 
      is to develop sound multicriteria approaches to enlighten healthcare
      decisionmaking and priority-setting.
FAU - Guindo, Lalla Aida
AU  - Guindo LA
AD  - BioMedCom Consultants, Montreal, Quebec, Canada.
      mireille_goetghebeur@biomedcom.org.
FAU - Wagner, Monika
AU  - Wagner M
FAU - Baltussen, Rob
AU  - Baltussen R
FAU - Rindress, Donna
AU  - Rindress D
FAU - van Til, Janine
AU  - van Til J
FAU - Kind, Paul
AU  - Kind P
FAU - Goetghebeur, Mireille M
AU  - Goetghebeur MM
LA  - eng
PT  - Journal Article
DEP - 20120718
PL  - England
TA  - Cost Eff Resour Alloc
JT  - Cost effectiveness and resource allocation : C/E
JID - 101170476
PMC - PMC3495194
EDAT- 2012/07/20 06:00
MHDA- 2012/07/20 06:01
CRDT- 2012/07/20 06:00
PHST- 2012/01/20 00:00 [received]
PHST- 2012/06/28 00:00 [accepted]
PHST- 2012/07/20 06:00 [entrez]
PHST- 2012/07/20 06:00 [pubmed]
PHST- 2012/07/20 06:01 [medline]
AID - 1478-7547-10-9 [pii]
AID - 10.1186/1478-7547-10-9 [doi]
PST - epublish
SO  - Cost Eff Resour Alloc. 2012 Jul 18;10(1):9. doi: 10.1186/1478-7547-10-9.


PMID- 22795078
OWN - NLM
STAT- MEDLINE
DCOM- 20121130
LR  - 20120716
IS  - 1873-2496 (Electronic)
IS  - 1078-1439 (Linking)
VI  - 30
IP  - 4 Suppl
DP  - 2012 Jul-Aug
TI  - A clinical trial primer: historical perspective and modern implementation.
PG  - S28-32
LID - 10.1016/j.urolonc.2011.05.012 [doi]
AB  - The structure of modern clinical trials is designed to protect patient safety
      while generating safety and efficacy data. Safety is the primary concern, and
      United States regulations are shaped by a series of responses to incidents,
      including notable safety lapses and unethical trials. These regulations focus on 
      3 essential components, defined by the 1979 Belmont Report: respect for persons, 
      beneficence, and justice. Further, the international community has formally
      outlined good clinical practice (GCP), which mandates that trials are designed to
      produce meaningful data, conform to international ethics regulations, and provide
      assurances that data are reported in a credible and reliable manner. The Food and
      Drug Administration (FDA) and federal government have outlined the necessary
      components of clinical trials in the Code of Federal Regulations (CFR). These
      include institutional review boards (IRBs), standard operating procedures (SOPs),
      sites, sponsors, investigators, and patients. The investigator is the center of
      the trial and is required to sign an agreement with the federal government to
      uphold the CFR. Investigator duties include making sure that investigator and
      support staff having appropriate qualifications, delegating duties, monitoring
      the study for compliance and record keeping, providing care, and accepting
      accountability for the trial, among other duties. Physicians, who already have
      significant time demands, need a well-trained staff, including clinical
      coordinators, to adequately meet these duties. Despite these requirements, trials
      can have significant benefits for investigators, practices, and patients,
      foremost of which is the ability to provide cutting edge care. However, the
      clinical trial process requires routine evaluation and continual performance
      improvement in order to ensure that patients not only receive excellent care, but
      also do so in the safest possible manner.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Karsh, Lawrence I
AU  - Karsh LI
AD  - The Urology Center of Colorado, Denver, CO 80211, USA. larrykarsh@gmail.com
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Urol Oncol
JT  - Urologic oncology
JID - 9805460
SB  - IM
MH  - Biomedical Research/*standards
MH  - Clinical Trials as Topic/methods/*standards/trends
MH  - *Government Regulation
MH  - Human Experimentation/*standards
MH  - Humans
MH  - Patient Safety/standards
MH  - Practice Guidelines as Topic/standards
MH  - United States
MH  - United States Food and Drug Administration
EDAT- 2012/07/20 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/17 06:00
PHST- 2011/04/05 00:00 [received]
PHST- 2011/05/12 00:00 [revised]
PHST- 2011/05/18 00:00 [accepted]
PHST- 2012/07/17 06:00 [entrez]
PHST- 2012/07/20 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - S1078-1439(11)00152-9 [pii]
AID - 10.1016/j.urolonc.2011.05.012 [doi]
PST - ppublish
SO  - Urol Oncol. 2012 Jul-Aug;30(4 Suppl):S28-32. doi: 10.1016/j.urolonc.2011.05.012.


PMID- 22808449
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120809
LR  - 20211021
IS  - 2158-8341 (Electronic)
IS  - 2158-8333 (Linking)
VI  - 9
IP  - 5-6
DP  - 2012 May
TI  - Informed consent, participation in research, and the Alzheimer's patient.
PG  - 47-51
AB  - Patients with Alzheimer's disease may want to participate in research on
      Alzheimer's disease, but their participation involves exceptional considerations.
      Plans should be made for determining these patients' cognitive capacity on a
      regular basis; for example, throughout a study, cognitive capacity may decline,
      making it necessary for a patient's pre-designated surrogate decision maker to
      become more involved. Patients with Alzheimer's disease may also choose to
      designate someone other than their primary caregiver to be their surrogate
      decision maker. This article discusses these and other core ethical issues.
FAU - Howe, Edmund
AU  - Howe E
AD  - Department of Psychiatry, Uniformed Services University of the Health Sciences,
      Bethesda, Maryland, USA. edmund.howe@usuhs.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Innov Clin Neurosci
JT  - Innovations in clinical neuroscience
JID - 101549695
PMC - PMC3398682
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Informed consent
OT  - MCI
OT  - mental capacity
OT  - minimal cognitive impairment
OT  - research
OT  - surrogate decision maker
EDAT- 2012/07/19 06:00
MHDA- 2012/07/19 06:01
CRDT- 2012/07/19 06:00
PHST- 2012/07/19 06:00 [entrez]
PHST- 2012/07/19 06:00 [pubmed]
PHST- 2012/07/19 06:01 [medline]
PST - ppublish
SO  - Innov Clin Neurosci. 2012 May;9(5-6):47-51.


PMID- 22808331
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1942-0889 (Electronic)
IS  - 1942-0889 (Linking)
VI  - 5
IP  - 2
DP  - 2012 Mar 1
TI  - Application of game theory to the interface between militarization and
      environmental stewardship in the Mariana Islands.
PG  - 193-5
LID - 10.4161/cib.18889 [doi]
AB  - We recently described threats to the terrestrial biological resources on the
      Mariana islands of Guam and Tinian resulting from the large-scale buildup of
      military operations. Attitudes that view these military buildup plans in a zero
      sum context whereby the positives of greater security and improved local economy 
      can be attained only with corresponding negatives of environmental destruction
      are prevalent. We argue these attitudes oversimplify the complicated interactions
      between military operations and environmental damage. Here we discuss aspects of 
      our case study that would benefit from application of game theory. Declines in
      ecosystem health are not unavoidable forms of collateral damage of peace-time
      military operations. We repeat, conservation of environmental resources is not
      ancillary to national security, it is integral.
FAU - Marler, Thomas E
AU  - Marler TE
AD  - Western Pacific Tropical Research Center; University of Guam; UOG Station;
      Mangilao, GU USA.
FAU - Wiecko, Greg
AU  - Wiecko G
FAU - Moore, Aubrey
AU  - Moore A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Commun Integr Biol
JT  - Communicative & integrative biology
JID - 101478473
PMC - PMC3376062
OTO - NOTNLM
OT  - ecological ethics
OT  - militarization
OT  - military
OT  - tragedy of the commons
OT  - warfare ecology
EDAT- 2012/07/19 06:00
MHDA- 2012/07/19 06:01
CRDT- 2012/07/19 06:00
PHST- 2012/07/19 06:00 [entrez]
PHST- 2012/07/19 06:00 [pubmed]
PHST- 2012/07/19 06:01 [medline]
AID - 10.4161/cib.18889 [doi]
AID - 2011CIB0217 [pii]
PST - ppublish
SO  - Commun Integr Biol. 2012 Mar 1;5(2):193-5. doi: 10.4161/cib.18889.


PMID- 22808227
OWN - NLM
STAT- MEDLINE
DCOM- 20130110
LR  - 20220321
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 7
DP  - 2012
TI  - HIV and dyadic intervention: an interdependence and communal coping analysis.
PG  - e40661
LID - 10.1371/journal.pone.0040661 [doi]
AB  - BACKGROUND: The most common form of HIV transmission in sub-Saharan Africa is
      heterosexual sex between two partners. While most HIV prevention interventions
      are aimed at the individual, there is mounting evidence of the feasibility,
      acceptability, and efficacy of dyadic interventions. However, the mechanisms
      through which dyadic-level interventions achieve success remain little explored. 
      We address this gap by using Lewis et al's interdependence model of couple
      communal coping and behaviour change to analyse data from partners participating 
      in an HIV prevention trial in Uganda and Zambia. METHODS AND FINDINGS: We
      conducted a comparative qualitative study using in-depth interviews. Thirty-three
      interviews were conducted in total; ten with couples and twenty-three with staff 
      members at the two sites. The Ugandan site recruited a sero-discordant couple
      cohort and the Zambian site recruited women alone. Spouses' transformation of
      motivation is strong where couples are recruited and both partners stand to gain 
      considerably by participating in the research; it is weaker where this is not the
      case. As such, coping mechanisms differ in the two sites; among sero-discordant
      couples in Uganda, communal coping is evidenced through joint consent to
      participate, regular couple counselling and workshops, sharing of HIV test
      results, and strong spousal support for adherence and retention. By contrast,
      coping at the Zambian site is predominantly left to the individual woman and
      occurs against a backdrop of mutual mistrust and male disenfranchisement. We
      discuss these findings in light of practical and ethical considerations of
      recruiting couples to HIV research. CONCLUSIONS: We argue for the need to
      consider the broader context within which behaviour change occurs and propose
      that future dyadic research be situated within the framework of the 'risk
      environment'.
FAU - Montgomery, Catherine M
AU  - Montgomery CM
AD  - Institute for Science, Innovation and Society, School of Anthropology and Museum 
      Ethnography, University of Oxford, Oxford, United Kingdom.
      catherine.montgomery@insis.ox.ac.uk
FAU - Watts, Charlotte
AU  - Watts C
FAU - Pool, Robert
AU  - Pool R
LA  - eng
GR  - G0100137/MRC_/Medical Research Council/United Kingdom
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120712
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - *Adaptation, Psychological
MH  - Clinical Trials, Phase III as Topic
MH  - Cohort Studies
MH  - *Family Characteristics
MH  - Female
MH  - *HIV
MH  - HIV Infections/*prevention & control/*psychology/transmission/virology
MH  - HIV Seropositivity/psychology/transmission/virology
MH  - *Health Behavior
MH  - *Health Education
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Motivation
MH  - Uganda
MH  - Zambia
PMC - PMC3395677
EDAT- 2012/07/19 06:00
MHDA- 2013/01/11 06:00
CRDT- 2012/07/19 06:00
PHST- 2012/01/30 00:00 [received]
PHST- 2012/06/11 00:00 [accepted]
PHST- 2012/07/19 06:00 [entrez]
PHST- 2012/07/19 06:00 [pubmed]
PHST- 2013/01/11 06:00 [medline]
AID - 10.1371/journal.pone.0040661 [doi]
AID - PONE-D-12-03291 [pii]
PST - ppublish
SO  - PLoS One. 2012;7(7):e40661. doi: 10.1371/journal.pone.0040661. Epub 2012 Jul 12.


PMID- 22807943
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2092-9900 (Electronic)
IS  - 1738-6756 (Linking)
VI  - 15
IP  - 2
DP  - 2012 Jun
TI  - Survey of the application of the korean clinical practice recommendations on
      breast cancer treatment: the utility of the korean breast cancer society
      guidelines.
PG  - 239-43
LID - 10.4048/jbc.2012.15.2.239 [doi]
AB  - This survey was performed to analyze the usability of the third edition of the
      Korean breast cancer clinical practice guidelines (KBCCPG) in clinical practice. 
      We made a questionnaire composed of 18 general and 82 specific questions
      regarding benign breast disease (B; 1 question); non-invasive disease (N; 12
      questions); early-stage disease (E; 26 questions); advanced disease (A; 24
      questions); and metastatic (M) breast cancer-related problems (19 questions). A
      total of 100 questionnaires, with a link to an online survey, were delivered via 
      e-mail to over 700 members of the Korean Breast Cancer Society (KBCS), and
      associated academy members, over 20 days between 26th February and 16th May 2010.
      Out of 270 respondents who read the e-mail, 96 answered the questionnaire.
      Participants included 87 surgical oncologists, 5 radiation oncologists, 2
      oncoplastic surgeons, 1 pathologist, and 1 medical oncologist. The third KBCCPG
      were perceived as differing from the second guidelines in terms of the level of
      clinical evidence required before choosing a recommendation. For the progress of 
      the KBCCPG, the guideline committee should try to reinforce all courses of
      guideline development with several elements including data from clinical trials
      of Korean breast cancer patients, securing a multidisciplinary approach,
      developing consistent and reasonable processes for each step of the revision of
      the guidelines, induction of liberal scientific and ethical discussion about all 
      issues with all KBCS members. The cost-effectiveness of healthcare and the
      logical development of the KBCCPG would also be ensured. Timely updates of the
      clinical guidelines for breast cancer treatment are essential to facilitate
      optimal decision-making in daily practice, and to ensure adequate patient
      feedback.
FAU - Gwak, Geumhee
AU  - Gwak G
AD  - Department of Surgery, Inje University Sanggye Paik Hospital, Seoul, Korea.
FAU - Lee, Hae Kyung
AU  - Lee HK
FAU - Kim, Hee Jung
AU  - Kim HJ
FAU - Lee, Si Youn
AU  - Lee SY
FAU - Park, Yong Lai
AU  - Park YL
FAU - Lee, Jong Won
AU  - Lee JW
FAU - Kim, Seung Gi
AU  - Kim SG
FAU - Huh, Ho
AU  - Huh H
FAU - Shin, Hyukjai
AU  - Shin H
FAU - Kim, Je Ryong
AU  - Kim JR
FAU - Ahn, Jin-Seok
AU  - Ahn JS
FAU - Son, Ju Hyuk
AU  - Son JH
FAU - Lee, Il Gyun
AU  - Lee IG
FAU - Park, Woo Chan
AU  - Park WC
FAU - Kim, Sung Yong
AU  - Kim SY
FAU - Han, Sehwan
AU  - Han S
FAU - Lee, Eun Sook
AU  - Lee ES
CN  - Korean Breast Cancer Society
CN  - Korea Breast Cancer Foundation
LA  - eng
PT  - Journal Article
DEP - 20120628
PL  - Korea (South)
TA  - J Breast Cancer
JT  - Journal of breast cancer
JID - 101314183
PMC - PMC3395749
OTO - NOTNLM
OT  - Breast neoplasms
OT  - Guideline
OT  - Korea
OT  - Surveys
EDAT- 2012/07/19 06:00
MHDA- 2012/07/19 06:01
CRDT- 2012/07/19 06:00
PHST- 2012/02/09 00:00 [received]
PHST- 2012/04/09 00:00 [accepted]
PHST- 2012/07/19 06:00 [entrez]
PHST- 2012/07/19 06:00 [pubmed]
PHST- 2012/07/19 06:01 [medline]
AID - 10.4048/jbc.2012.15.2.239 [doi]
PST - ppublish
SO  - J Breast Cancer. 2012 Jun;15(2):239-43. doi: 10.4048/jbc.2012.15.2.239. Epub 2012
      Jun 28.


PMID- 22807638
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1178-7074 (Electronic)
IS  - 1178-7074 (Linking)
VI  - 5
DP  - 2012
TI  - Autologous cord blood harvesting in North Eastern Italy: ethical questions and
      emerging hopes for curing diabetes and celiac disease.
PG  - 511-6
LID - 10.2147/IJGM.S31977 [doi]
AB  - BACKGROUND: The Friuli Venezia Giulia (FVG), a region of North Eastern Italy, has
      passed legislation (Decree No 2324/2010) to regulate the banking of umbilical
      cord blood samples for personal, autologous, or family-directed use, and to
      implement the Agreement of the State-Regions Permanent Conference (Decree No
      62/CSR/2010). This paper aims to identify the formalities and the reasons why
      families collect and bank their cord blood in foreign banks for both personal and
      private use. METHODS: To this end, at the Institute for Maternal and Child Health
      of Trieste (the regional capital city of the FVG), Italy, which assists about
      1800 pregnant women a year, 129 questionnaires, drafted from January 2010 to
      December 2011 and concerning the granting of authorization to export samples,
      were examined. RESULTS: The collected data showed that 75% of involved families
      had resorted to anonymous public collection, which is available to anyone with
      therapeutic needs, and provided compatibility and hematologic protocols
      recognized by the scientific and international community (main indications:
      leukemia, hemoglobinopaties, and inherited hematologic and immunologic
      disorders). Conversely, 25.0% requested private storage at a foreign bank for
      personal or family-dedicated use. The principal motivation by disease was for
      treatment for diabetes (22.4%) and celiac disease (19.7%) (a multiorgan disease
      for which the FVG region has provided safeguards by approving a specific law
      granting support to families; Decree No 561/2007). For these two types of disease
      we found that information was received from the internet and not from general
      medical physicians, with a significant difference found using the chi(2) test (P 
      < 0.01). CONCLUSION: The indication of treating these diseases with cord blood
      stem cell transplantation appears to be well grounded and encouraging, and has
      recently been corroborated by the international literature; however, the economic
      and social motivations promoting cord blood storage, for a fee, in the event of
      diseases that are still under study, require accurate information through general
      medical physicians on the actual possibilities of treatment.
FAU - Parco, Sergio
AU  - Parco S
AD  - Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy.
FAU - Vascotto, Fulvia
AU  - Vascotto F
LA  - eng
PT  - Journal Article
DEP - 20120615
PL  - New Zealand
TA  - Int J Gen Med
JT  - International journal of general medicine
JID - 101515487
PMC - PMC3396118
OTO - NOTNLM
OT  - North Eastern Italy
OT  - autologous cord blood harvesting
OT  - emerging hopes of therapy
EDAT- 2012/07/19 06:00
MHDA- 2012/07/19 06:01
CRDT- 2012/07/19 06:00
PHST- 2012/07/19 06:00 [entrez]
PHST- 2012/07/19 06:00 [pubmed]
PHST- 2012/07/19 06:01 [medline]
AID - 10.2147/IJGM.S31977 [doi]
AID - ijgm-5-511 [pii]
PST - ppublish
SO  - Int J Gen Med. 2012;5:511-6. doi: 10.2147/IJGM.S31977. Epub 2012 Jun 15.


PMID- 22807572
OWN - NLM
STAT- MEDLINE
DCOM- 20130108
LR  - 20181202
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 11
DP  - 2012 Nov
TI  - Ethical considerations for performing decompressive craniectomy as a life-saving 
      intervention for severe traumatic brain injury.
PG  - 657-61
LID - 10.1136/medethics-2012-100672 [doi]
AB  - In all fields of clinical medicine, there is an increasing awareness that outcome
      must be assessed in terms of quality of life and cost effectiveness, rather than 
      merely length of survival. This is especially the case when considering
      decompressive craniectomy for severe traumatic brain injury. The procedure itself
      is technically straightforward and involves temporarily removing a large section 
      of the skull vault in order to provide extra space into which the injured brain
      can expand. A number of studies have demonstrated many patients going on to make 
      a good long-term functional recovery, however, this is not always the case and a 
      significant number survive but are left with severe neurocognitive impairment.
      Unfortunately, many of these patients are young adults who were previously fit
      and well and are, therefore, likely to spend many years in a condition that they 
      may feel to be unacceptable, and this raises a number of ethical issues regarding
      consent and resource allocation. In an attempt to address these issues, we have
      used the analytical framework proposed by Jonsen, that requires systematic
      consideration of medical indications, patient preferences, quality of life and
      contextual features.
FAU - Honeybul, Stephen
AU  - Honeybul S
AD  - Department of Neurosurgery, Sir Charles Gairdner Hospital, Hospital Avenue, Perth
      6009, Australia. stephen.honeybul@health.wa.gov.au
FAU - Gillett, Grant
AU  - Gillett G
FAU - Ho, Kwok
AU  - Ho K
FAU - Lind, Christopher
AU  - Lind C
LA  - eng
PT  - Journal Article
DEP - 20120717
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
CIN - J Med Ethics. 2012 Nov;38(11):662-3. PMID: 23019181
MH  - Adult
MH  - Australia
MH  - Brain Injuries/*surgery
MH  - Cost of Illness
MH  - Cost-Benefit Analysis
MH  - Decompressive Craniectomy/*ethics/standards
MH  - Ethics, Medical
MH  - Health Resources/statistics & numerical data
MH  - Humans
MH  - *Informed Consent
MH  - Injury Severity Score
MH  - Personal Autonomy
MH  - *Quality of Life
MH  - Quality-Adjusted Life Years
MH  - Risk Assessment
MH  - Treatment Outcome
EDAT- 2012/07/19 06:00
MHDA- 2013/01/09 06:00
CRDT- 2012/07/19 06:00
PHST- 2012/07/19 06:00 [entrez]
PHST- 2012/07/19 06:00 [pubmed]
PHST- 2013/01/09 06:00 [medline]
AID - medethics-2012-100672 [pii]
AID - 10.1136/medethics-2012-100672 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Nov;38(11):657-61. doi: 10.1136/medethics-2012-100672. Epub
      2012 Jul 17.


PMID- 22807483
OWN - NLM
STAT- MEDLINE
DCOM- 20121129
LR  - 20131121
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 264
IP  - 3
DP  - 2012 Sep
TI  - Distribution of brain sodium accumulation correlates with disability in multiple 
      sclerosis: a cross-sectional 23Na MR imaging study.
PG  - 859-67
LID - 10.1148/radiol.12112680 [doi]
AB  - PURPOSE: To quantify brain sodium accumulations and characterize for the first
      time the spatial location of sodium abnormalities at different stages of
      relapsing-remitting (RR) multiple sclerosis (MS) by using sodium 23 ((23)Na)
      magnetic resonance (MR) imaging. MATERIALS AND METHODS: This study was approved
      by the local committee on ethics, and written informed consent was obtained from 
      all participants. Three-dimensional (23)Na MR imaging data were obtained with a
      3.0-T unit in two groups of patients with RR MS-14 with early RR MS (disease
      duration <5 years) and 12 with advanced RR MS (disease duration >5 years)-and 15 
      control subjects. Quantitative assessment of total sodium concentration (TSC)
      levels within compartments (MS lesions, white matter [WM], and gray matter [GM]) 
      as well as statistical mapping analyses of TSC abnormalities were performed.
      RESULTS: TSC was increased inside demyelinating lesions in both groups of
      patients, whereas increased TSC was observed in normal-appearing WM and GM only
      in those with advanced RR MS. In patients, increased TSC inside GM was correlated
      with disability (as determined with the Expanded Disability Status Scale [EDSS]
      score; P = .046, corrected) and lesion load at T2-weighted imaging (P = .003,
      corrected) but not with disease duration (P = .089, corrected). Statistical
      mapping analysis showed confined TSC increases inside the brainstem, cerebellum, 
      and temporal poles in early RR MS and widespread TSC increases that affected the 
      entire brain in advanced RR MS. EDSS score correlated with TSC increases inside
      motor networks. CONCLUSION: TSC accumulation dramatically increases in the
      advanced stage of RR MS, especially in the normal-appearing brain tissues,
      concomitant with disability. Brain sodium MR imaging may help monitor the
      occurrence of tissue injury and disability.
CI  - (c) RSNA, 2012
FAU - Zaaraoui, Wafaa
AU  - Zaaraoui W
AD  - CRMBM, no. 7339, Aix-Marseille University, CNRS, Marseille, France.
      wafaa.zaaraoui@univmed.fr
FAU - Konstandin, Simon
AU  - Konstandin S
FAU - Audoin, Bertrand
AU  - Audoin B
FAU - Nagel, Armin M
AU  - Nagel AM
FAU - Rico, Audrey
AU  - Rico A
FAU - Malikova, Irina
AU  - Malikova I
FAU - Soulier, Elisabeth
AU  - Soulier E
FAU - Viout, Patrick
AU  - Viout P
FAU - Confort-Gouny, Sylviane
AU  - Confort-Gouny S
FAU - Cozzone, Patrick J
AU  - Cozzone PJ
FAU - Pelletier, Jean
AU  - Pelletier J
FAU - Schad, Lothar R
AU  - Schad LR
FAU - Ranjeva, Jean-Philippe
AU  - Ranjeva JP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120717
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 9NEZ333N27 (Sodium)
SB  - IM
MH  - Adult
MH  - Area Under Curve
MH  - Brain/*metabolism
MH  - Disability Evaluation
MH  - Female
MH  - Humans
MH  - Image Enhancement
MH  - Image Interpretation, Computer-Assisted
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis, Relapsing-Remitting/*metabolism/*physiopathology
MH  - Regression Analysis
MH  - Sodium/*metabolism
MH  - Statistics, Nonparametric
EDAT- 2012/07/19 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/19 06:00
PHST- 2012/07/19 06:00 [entrez]
PHST- 2012/07/19 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - radiol.12112680 [pii]
AID - 10.1148/radiol.12112680 [doi]
PST - ppublish
SO  - Radiology. 2012 Sep;264(3):859-67. doi: 10.1148/radiol.12112680. Epub 2012 Jul
      17.


PMID- 22806510
OWN - NLM
STAT- MEDLINE
DCOM- 20130524
LR  - 20211021
IS  - 1432-2218 (Electronic)
IS  - 0930-2794 (Linking)
VI  - 27
IP  - 1
DP  - 2013 Jan
TI  - The unacknowledged incidence of laparoscopic stapler malfunction.
PG  - 86-9
LID - 10.1007/s00464-012-2417-y [doi]
AB  - BACKGROUND: Laparoscopic instruments are being used with increasing frequency.
      Our surgeons recently experienced several independent adverse events involving
      the laparoscopic linear stapler. Although the Food and Drug Administration
      maintains a Manufacturer and User Facility Device Experience (MAUDE) database to 
      track such voluntary reports, many events are not reported and the true incidence
      of adverse events is unknown. We attempted to determine how frequently minimally 
      invasive surgeons have experienced technical problems with a laparoscopic
      stapler. METHODS: Following IRB approval, we electronically distributed an
      anonymous 10-question survey to the 124 minimally invasive program directors
      listed in the Fellowship Council database. The questions focused on personal or
      peer experience with laparoscopic stapler malfunction, frequency and type of
      malfunction, device manufacturer, whether the operation was altered, and root
      cause analysis of the event. RESULTS: Forty-four of the 124 program directors
      (35%) completed the survey. The majority reported personal or peer experience
      (86%) with a linear stapler not releasing (66%) or not firing (73%) after
      application, with 27% of the respondents noting that this occurred three or more 
      times. The malfunction was not related to type of load, straight (23%) or
      reticulating (32%) model, or manufacturer (Ethicon 30%, Covidien 36%). One
      quarter of the respondents noted that the malfunction caused them to
      significantly alter their operative procedure, and 30% reported that they
      received no helpful feedback from the manufacturer despite contacting it.
      CONCLUSIONS: Most minimally invasive surgeons have experienced laparoscopic
      linear stapler malfunction and 25% have had to significantly alter the planned
      operative procedure due to the malfunction.
FAU - Kwazneski, Douglas 2nd
AU  - Kwazneski D 2nd
AD  - Department of Surgery, University of Pittsburgh Medical Center Mercy, Pittsburgh,
      PA 15219, USA. kwazneskidr@upmc.edu
FAU - Six, Cheryl
AU  - Six C
FAU - Stahlfeld, Kurt
AU  - Stahlfeld K
LA  - eng
PT  - Journal Article
DEP - 20120718
PL  - Germany
TA  - Surg Endosc
JT  - Surgical endoscopy
JID - 8806653
SB  - IM
MH  - Equipment Failure/*statistics & numerical data
MH  - Humans
MH  - Laparoscopy/*instrumentation
MH  - Surgical Staplers/*standards
EDAT- 2012/07/19 06:00
MHDA- 2013/05/28 06:00
CRDT- 2012/07/19 06:00
PHST- 2012/03/03 00:00 [received]
PHST- 2012/05/25 00:00 [accepted]
PHST- 2012/07/19 06:00 [entrez]
PHST- 2012/07/19 06:00 [pubmed]
PHST- 2013/05/28 06:00 [medline]
AID - 10.1007/s00464-012-2417-y [doi]
PST - ppublish
SO  - Surg Endosc. 2013 Jan;27(1):86-9. doi: 10.1007/s00464-012-2417-y. Epub 2012 Jul
      18.


PMID- 22806218
OWN - NLM
STAT- MEDLINE
DCOM- 20140122
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 3
DP  - 2013 Sep
TI  - Virtues in participatory design: cooperation, curiosity, creativity, empowerment 
      and reflexivity.
PG  - 945-62
LID - 10.1007/s11948-012-9380-9 [doi]
AB  - In this essay several virtues are discussed that are needed in people who work in
      participatory design (PD). The term PD is used here to refer specifically to an
      approach in designing information systems with its roots in Scandinavia in the
      1970s and 1980s. Through the lens of virtue ethics and based on key texts in PD, 
      the virtues of cooperation, curiosity, creativity, empowerment and reflexivity
      are discussed. Cooperation helps people in PD projects to engage in cooperative
      curiosity and cooperative creativity. Curiosity helps them to empathize with
      others and their experiences, and to engage in joint learning. Creativity helps
      them to envision, try out and materialize ideas, and to jointly create new
      products and services. Empowerment helps them to share power and to enable other 
      people to flourish. Moreover, reflexivity helps them to perceive and to modify
      their own thoughts, feelings and actions. In the spirit of virtue ethics-which
      focuses on specific people in concrete situations-several examples from one PD
      project are provided. Virtue ethics is likely to appeal to people in PD projects 
      because it is practice-oriented, provides room for exploration and
      experimentation, and promotes professional and personal development. In closing, 
      some ideas for practical application, for education and for further research are 
      discussed.
FAU - Steen, Marc
AU  - Steen M
AD  - TNO, Delft, The Netherlands. marc.steen@tno.nl
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120718
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - *Community Participation
MH  - *Cooperative Behavior
MH  - Creativity
MH  - Emotions
MH  - *Engineering
MH  - Exploratory Behavior
MH  - Humans
MH  - *Information Systems
MH  - Perception
MH  - *Power, Psychological
MH  - *Thinking
MH  - *Virtues
EDAT- 2012/07/19 06:00
MHDA- 2014/01/23 06:00
CRDT- 2012/07/19 06:00
PHST- 2012/03/15 00:00 [received]
PHST- 2012/06/21 00:00 [accepted]
PHST- 2012/07/19 06:00 [entrez]
PHST- 2012/07/19 06:00 [pubmed]
PHST- 2014/01/23 06:00 [medline]
AID - 10.1007/s11948-012-9380-9 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Sep;19(3):945-62. doi: 10.1007/s11948-012-9380-9. Epub 2012 
      Jul 18.


PMID- 22805384
OWN - NLM
STAT- MEDLINE
DCOM- 20120830
LR  - 20120718
IS  - 1319-2442 (Print)
IS  - 1319-2442 (Linking)
VI  - 23
IP  - 4
DP  - 2012 Jul
TI  - The perception of organ donation among health-care providers in the intensive
      care units at a tertiary center.
PG  - 724-8
LID - 10.4103/1319-2442.98147 [doi]
AB  - The growing demand for organs continues to outpace the supply. The aim of our
      study was to evaluate the knowledge, attitude and awareness of organ donation
      procedures among the health-care providers in the Intensive Care Units (ICUs) at 
      a tertiary hospital. This was a questionnaire-based study conducted in December
      2011 among the health-care providers at five ICUs in a tertiary teaching hospital
      in Riyadh, Saudi Arabia. A total of 154 participants completed the questionnaire.
      Eighty percent of the participants acknowledged that organ donation is a legal
      practice in Saudi Arabia, but only 73% knew that the hospital had an organ
      donation policy. However, only 34% were willing to participate in a training
      program for organ donation. Interestingly, only 57% were willing to donate their 
      organs. Our results suggest that more measures should be taken to educate the
      health-care providers regarding the concept of organ donation and the ethical and
      religious beliefs. Also, the policy of the hospital and the Saudi Center for
      Organ Transplantation regarding the process of organ donation should be strongly 
      emphasized.
FAU - Alsultan, Mohammad
AU  - Alsultan M
AD  - College of Medicine, King Saud Bin Abdulaziz University for Health Sciences,
      Riyadh, Saudi Arabia. malsultan@msn.com
LA  - eng
PT  - Journal Article
PL  - Saudi Arabia
TA  - Saudi J Kidney Dis Transpl
JT  - Saudi journal of kidney diseases and transplantation : an official publication of
      the Saudi Center for Organ Transplantation, Saudi Arabia
JID - 9436968
SB  - IM
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Intensive Care Units
MH  - Male
MH  - *Tissue and Organ Procurement
MH  - Young Adult
EDAT- 2012/07/19 06:00
MHDA- 2012/08/31 06:00
CRDT- 2012/07/19 06:00
PHST- 2012/07/19 06:00 [entrez]
PHST- 2012/07/19 06:00 [pubmed]
PHST- 2012/08/31 06:00 [medline]
AID - SaudiJKidneyDisTranspl_2012_23_4_724_98147 [pii]
AID - 10.4103/1319-2442.98147 [doi]
PST - ppublish
SO  - Saudi J Kidney Dis Transpl. 2012 Jul;23(4):724-8. doi: 10.4103/1319-2442.98147.


PMID- 22804790
OWN - NLM
STAT- MEDLINE
DCOM- 20131206
LR  - 20181202
IS  - 1471-6712 (Electronic)
IS  - 0283-9318 (Linking)
VI  - 27
IP  - 2
DP  - 2013 Jun
TI  - Physicians' attitudes about interprofessional treatment of chronic pain: family
      physicians are considered the most important collaborators.
PG  - 303-10
LID - 10.1111/j.1471-6712.2012.01039.x [doi]
AB  - AIMS AND OBJECTIVES: Interprofessional collaboration is the process in which
      different professional groups work together to positively impact health care. We 
      aimed to explore physicians' attitudes toward interprofessional collaboration in 
      the context of chronic pain management with the implication that if attitudes are
      not positive, appropriate interventions could be developed. DESIGN: A
      quantitative attitudes study. ETHICAL ISSUES: The ethical committee approved the 
      study. METHODS: A web-based survey about interprofessional treatment of chronic
      pain was administered to physicians. Outcome measures were as follows:
      physicians' demographic and workplace information, previous experience of working
      within an interprofessional team, and attitudes towards interprofessional
      collaboration in chronic pain management. RESULTS: There were 90 physicians who
      responded to the survey. Physicians had positive attitudes towards team work in
      the context of chronic pain, but they were undecided about sharing their role
      within an interprofessional team. The family physician was singled out as the
      most important as well as the most common collaborator in chronic pain treatment.
      Interprofessional educational seminars and workshops were suggested as methods
      for improving interprofessional collaboration. CONCLUSIONS: Interprofessional
      collaboration may be enhanced with continuing medical education that will bring
      together different healthcare professionals, enable them to exchange experiences 
      and learn about their potential roles within a team.
CI  - (c) 2012 Nordic College of Caring Science.
FAU - Klinar, Ivana
AU  - Klinar I
AD  - Pliva Hrvatska d.o.o., Zagreb, Croatia.
FAU - Ferhatovic, Lejla
AU  - Ferhatovic L
FAU - Banozic, Adriana
AU  - Banozic A
FAU - Raguz, Marija
AU  - Raguz M
FAU - Kostic, Sandra
AU  - Kostic S
FAU - Sapunar, Damir
AU  - Sapunar D
FAU - Puljak, Livia
AU  - Puljak L
LA  - eng
PT  - Journal Article
DEP - 20120715
PL  - Sweden
TA  - Scand J Caring Sci
JT  - Scandinavian journal of caring sciences
JID - 8804206
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Chronic Pain/*therapy
MH  - *Cooperative Behavior
MH  - *Family Practice
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Physicians/*psychology
MH  - Workforce
EDAT- 2012/07/19 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/07/19 06:00
PHST- 2012/07/19 06:00 [entrez]
PHST- 2012/07/19 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1111/j.1471-6712.2012.01039.x [doi]
PST - ppublish
SO  - Scand J Caring Sci. 2013 Jun;27(2):303-10. doi: 10.1111/j.1471-6712.2012.01039.x.
      Epub 2012 Jul 15.


PMID- 22804708
OWN - NLM
STAT- MEDLINE
DCOM- 20130107
LR  - 20171116
IS  - 1095-8355 (Electronic)
IS  - 1065-6995 (Linking)
VI  - 36
IP  - 10
DP  - 2012 Oct 1
TI  - Human endometrial stem cell neurogenesis in response to NGF and bFGF.
PG  - 961-6
LID - 10.1042/CBI20110610 [doi]
AB  - The potential of cell therapy is promising in nerve regeneration, but is limited 
      by ethical considerations about the proper and technically safe source of stem
      cells. We report the successful differentiation of human EnSCs (endometrial stem 
      cells) as a rich source of renewable and safe progenitors into high-efficiency
      cholinergic neurons. The extracellular signals of NGF (nerve growth factor) and
      bFGF (basic fibroblast growth factor) could induce cholinergic neuron
      differentiation. ChAT (choline acetyltransferase), MAP2 (microtubule associated
      protein 2) and NF-l (neurofilament L) increased after administration of bFGF and 
      NGF to the EnSC cultures. trkC and FGFR2 (fibroblast growth factor receptor 2),
      which belong to the NGF and bFGF receptors respectively, were determined in
      populations of EnSCs. NGF, bFGF and their combination differentially influenced
      human EnSCs high efficiency differentiation. By inducing cholinergic neurons from
      EnSCs in a chemically defined medium, we could produce human neural cells without
      resorting to primary culture of neurons. This in vitro method provides an
      unlimited source of human neural cells and facilitates clinical applications of
      EnSCs for neurological diseases.
FAU - Noureddini, Mahdi
AU  - Noureddini M
AD  - *Department of Physiology, School of Medicine, Kashan University of Medical
      Sciences, Iran.
FAU - Verdi, Javad
AU  - Verdi J
FAU - Mortazavi-Tabatabaei, Seyed Abdolreza
AU  - Mortazavi-Tabatabaei SA
FAU - Sharif, Shiva
AU  - Sharif S
FAU - Azimi, Alireza
AU  - Azimi A
FAU - Keyhanvar, Peyman
AU  - Keyhanvar P
FAU - Shoae-Hassani, Alireza
AU  - Shoae-Hassani A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Cell Biol Int
JT  - Cell biology international
JID - 9307129
RN  - 0 (CD146 Antigen)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neurofilament Proteins)
RN  - 0 (Octamer Transcription Factor-3)
RN  - 0 (Thy-1 Antigens)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
RN  - 0 (neurofilament protein L)
RN  - 103107-01-3 (Fibroblast Growth Factor 2)
RN  - EC 2.3.1.6 (Choline O-Acetyltransferase)
SB  - IM
MH  - Adult
MH  - CD146 Antigen/analysis
MH  - Cell Separation
MH  - Cell Survival
MH  - Cells, Cultured
MH  - Choline O-Acetyltransferase/analysis
MH  - Endometrium/*cytology
MH  - Female
MH  - Fibroblast Growth Factor 2/*metabolism
MH  - Humans
MH  - Microtubule-Associated Proteins/analysis
MH  - Nerve Growth Factors/*metabolism
MH  - Neurofilament Proteins/analysis
MH  - *Neurogenesis
MH  - Neurons/*cytology/metabolism
MH  - Octamer Transcription Factor-3/analysis
MH  - Stem Cells/*cytology
MH  - Thy-1 Antigens/analysis
MH  - Vascular Cell Adhesion Molecule-1/analysis
EDAT- 2012/07/19 06:00
MHDA- 2013/01/08 06:00
CRDT- 2012/07/19 06:00
PHST- 2012/07/19 06:00 [entrez]
PHST- 2012/07/19 06:00 [pubmed]
PHST- 2013/01/08 06:00 [medline]
AID - CBI20110610 [pii]
AID - 10.1042/CBI20110610 [doi]
PST - ppublish
SO  - Cell Biol Int. 2012 Oct 1;36(10):961-6. doi: 10.1042/CBI20110610.


PMID- 22803748
OWN - NLM
STAT- MEDLINE
DCOM- 20121130
LR  - 20120718
IS  - 1365-2923 (Electronic)
IS  - 0308-0110 (Linking)
VI  - 46
IP  - 8
DP  - 2012 Aug
TI  - A framework for the ethics review of education research.
PG  - 731-3
LID - 10.1111/j.1365-2923.2012.04293.x [doi]
FAU - Eikelboom, Jonneke I
AU  - Eikelboom JI
AD  - University Medical Centre Utrecht, Julius Centre for Medical Ethics,
      Universiteitsweg 100, 3584 CG Utrecht, the Netherlands.
      j.i.dankerlui-eikelboom-2@umcutrecht.nl
FAU - ten Cate, Olle Th J
AU  - ten Cate OT
FAU - Jaarsma, Debbie
AU  - Jaarsma D
FAU - Raat, Janet A N
AU  - Raat JA
FAU - Schuwirth, Lambert
AU  - Schuwirth L
FAU - van Delden, Johannes J M
AU  - van Delden JJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - Med Educ
JT  - Medical education
JID - 7605655
SB  - IM
MH  - *Biomedical Research
MH  - Education, Medical/*ethics
MH  - Ethical Review/*standards
MH  - Guidelines as Topic
MH  - Humans
EDAT- 2012/07/19 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/19 06:00
PHST- 2012/07/19 06:00 [entrez]
PHST- 2012/07/19 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1111/j.1365-2923.2012.04293.x [doi]
PST - ppublish
SO  - Med Educ. 2012 Aug;46(8):731-3. doi: 10.1111/j.1365-2923.2012.04293.x.


PMID- 22803648
OWN - NLM
STAT- MEDLINE
DCOM- 20121116
LR  - 20181201
IS  - 1365-2036 (Electronic)
IS  - 0269-2813 (Linking)
VI  - 36
IP  - 4
DP  - 2012 Aug
TI  - Commentary: comparators in H. pylori eradication -- stating the ethics of
      statins; author's reply.
PG  - 401
LID - 10.1111/j.1365-2036.2012.05193.x [doi]
FAU - Nseir, W
AU  - Nseir W
AD  - Internal Medicine Department and Infectious Diseases Unit, Holy Family Hospital, 
      Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Nazareth, Israel.
      w.nseir@yahoo.com
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - England
TA  - Aliment Pharmacol Ther
JT  - Alimentary pharmacology & therapeutics
JID - 8707234
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
RN  - 0 (Proton Pump Inhibitors)
RN  - AGG2FN16EV (Simvastatin)
SB  - IM
CON - Aliment Pharmacol Ther. 2012 Aug;36(4):400-1. PMID: 22803647
MH  - Anti-Bacterial Agents/*administration & dosage
MH  - Female
MH  - Helicobacter Infections/*drug therapy
MH  - Helicobacter pylori/*drug effects
MH  - Humans
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/*administration & dosage
MH  - Male
MH  - Proton Pump Inhibitors/*administration & dosage
MH  - Simvastatin/*administration & dosage
EDAT- 2012/07/19 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/19 06:00
PHST- 2012/07/19 06:00 [entrez]
PHST- 2012/07/19 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1111/j.1365-2036.2012.05193.x [doi]
PST - ppublish
SO  - Aliment Pharmacol Ther. 2012 Aug;36(4):401. doi:
      10.1111/j.1365-2036.2012.05193.x.


PMID- 22803647
OWN - NLM
STAT- MEDLINE
DCOM- 20121116
LR  - 20181201
IS  - 1365-2036 (Electronic)
IS  - 0269-2813 (Linking)
VI  - 36
IP  - 4
DP  - 2012 Aug
TI  - Commentary: comparators in H. pylori eradication--stating the ethics of statins.
PG  - 400-1
LID - 10.1111/j.1365-2036.2012.05191.x [doi]
FAU - McNicholl, A G
AU  - McNicholl AG
AD  - Department of Gastroenterology and Centro de Investigacion Biomedica en Red de
      Enfermedades Hepaticas y Digestivas, Hospital Universitario de La Princesa,
      Instituto de Investigacion Sanitaria Princesa (IP), Madrid, Spain.
FAU - Gisbert, J P
AU  - Gisbert JP
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - England
TA  - Aliment Pharmacol Ther
JT  - Alimentary pharmacology & therapeutics
JID - 8707234
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
RN  - 0 (Proton Pump Inhibitors)
RN  - AGG2FN16EV (Simvastatin)
SB  - IM
CON - Aliment Pharmacol Ther. 2012 Aug;36(3):231-8. PMID: 22646167
CIN - Aliment Pharmacol Ther. 2012 Aug;36(4):401. PMID: 22803648
MH  - Anti-Bacterial Agents/*administration & dosage
MH  - Female
MH  - Helicobacter Infections/*drug therapy
MH  - Helicobacter pylori/*drug effects
MH  - Humans
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/*administration & dosage
MH  - Male
MH  - Proton Pump Inhibitors/*administration & dosage
MH  - Simvastatin/*administration & dosage
EDAT- 2012/07/19 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/19 06:00
PHST- 2012/07/19 06:00 [entrez]
PHST- 2012/07/19 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1111/j.1365-2036.2012.05191.x [doi]
PST - ppublish
SO  - Aliment Pharmacol Ther. 2012 Aug;36(4):400-1. doi:
      10.1111/j.1365-2036.2012.05191.x.


PMID- 22803318
OWN - NLM
STAT- MEDLINE
DCOM- 20120802
LR  - 20191210
IS  - 1121-2233 (Print)
IS  - 1121-2233 (Linking)
VI  - 53
IP  - 1
DP  - 2012 Mar
TI  - Colorectal cancer screening in LHU4 Chiavarese, Italy: ethical, methodological
      and outcome evaluations at the end of the first round.
PG  - 37-43
AB  - UNLABELLED: INTRODUCTION. The screening programmes are very challenging from the 
      ethical perspective, and their impact in terms of morbidity and mortality make
      secondary colorectal cancer prevention a valuable public health intervention.
      METHODS: The target population people aged 50-69 years receive an invitation card
      with a test-tube for the fecal occult blood test (FOBT) and an immunochemical
      test is used for fecal occult blood. Subjects positive to FOBT are invited to
      perform a gastroenterologic examination and a full colonoscopy. RESULTS: In the
      firt round of screening, 100% of the target population has been invited with an
      adhesion rate of 41.3%. A total of 1739 FOBT-positive subjects have been invited 
      to the second level of the screening. 1429 of them have performed the
      gastroenterologic examination (83.9%). To date 956 full colonoscopies have been
      completed and the rate of subjects affected by carcinoma, malignant polyp and
      advanced adenoma has been equal to 23.5%. DISCUSSION: Thanks to the reminders
      already sent, an increasing compliance has been registered with an increased rate
      of subjects with a low schooling that have performed a FOBT test. With the aim to
      optimize all the operative aspects of the screening programme it is already
      ongoing a set of meetings between health workers of Local Health Unit 4 and
      General Practioners.
FAU - Ferrari Bravo, M
AU  - Ferrari Bravo M
AD  - Local Health Unit 4 Chiavarese, Hospital Medical Management.
FAU - De Conca, V
AU  - De Conca V
FAU - Devoto, G L
AU  - Devoto GL
FAU - Sironi, M
AU  - Sironi M
FAU - Mele, R
AU  - Mele R
FAU - Fumagalli, A
AU  - Fumagalli A
FAU - Rimassa, P
AU  - Rimassa P
FAU - Rossi, G
AU  - Rossi G
FAU - Zampogna, A
AU  - Zampogna A
FAU - Sticchi, C
AU  - Sticchi C
FAU - Gabutti, G
AU  - Gabutti G
CN  - Medical Screening Program Group
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - J Prev Med Hyg
JT  - Journal of preventive medicine and hygiene
JID - 9214440
RN  - 0 (Indicators and Reagents)
RN  - 0 (Reagent Kits, Diagnostic)
SB  - IM
MH  - Adenomatous Polyps/diagnosis/prevention & control
MH  - Aged
MH  - Catchment Area, Health
MH  - Colonoscopy/statistics & numerical data
MH  - Colorectal Neoplasms/*diagnosis/epidemiology/*prevention & control
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Indicators and Reagents
MH  - Italy/epidemiology
MH  - Male
MH  - Mass Screening/*methods
MH  - Middle Aged
MH  - National Health Programs/organization & administration
MH  - *Occult Blood
MH  - Outcome Assessment, Health Care
MH  - Patient Acceptance of Health Care/*statistics & numerical data
MH  - Patient Compliance
MH  - Prevalence
MH  - Reagent Kits, Diagnostic
MH  - Sigmoidoscopy/statistics & numerical data
IR  - Barbiroglio E
FIR - Barbiroglio, E
IR  - Erba S
FIR - Erba, S
IR  - Fabbri R
FIR - Fabbri, R
IR  - Lanata S
FIR - Lanata, S
IR  - Lunardi M
FIR - Lunardi, M
IR  - Saro F
FIR - Saro, F
IR  - Vajra C
FIR - Vajra, C
IR  - Alessio G
FIR - Alessio, G
IR  - Atzei M
FIR - Atzei, M
IR  - Avanzino G
FIR - Avanzino, G
IR  - Bacchella L
FIR - Bacchella, L
IR  - Baciocco C
FIR - Baciocco, C
IR  - Bancalari G
FIR - Bancalari, G
IR  - Bardino N
FIR - Bardino, N
IR  - Barlascini C
FIR - Barlascini, C
IR  - Barsotti M
FIR - Barsotti, M
IR  - Basso G
FIR - Basso, G
IR  - Bella C
FIR - Bella, C
IR  - Benvenuto M
FIR - Benvenuto, M
IR  - Bettinelli E
FIR - Bettinelli, E
IR  - Bixio M
FIR - Bixio, M
IR  - Bonetto L
FIR - Bonetto, L
IR  - Borzone S
FIR - Borzone, S
IR  - Brignole A
FIR - Brignole, A
IR  - Brunetti F
FIR - Brunetti, F
IR  - Buchignani D
FIR - Buchignani, D
IR  - Buzzi P
FIR - Buzzi, P
IR  - Cadigia M
FIR - Cadigia, M
IR  - Calcagno P
FIR - Calcagno, P
IR  - Carosio L
FIR - Carosio, L
IR  - Caruso F
FIR - Caruso, F
IR  - Cogorno S
FIR - Cogorno, S
IR  - Corea D
FIR - Corea, D
IR  - Costa M
FIR - Costa, M
IR  - Cucuccio I
FIR - Cucuccio, I
IR  - Curlo G
FIR - Curlo, G
IR  - Dapelo F
FIR - Dapelo, F
IR  - D'Asta F
FIR - D'Asta, F
IR  - DeFerrari E
FIR - DeFerrari, E
IR  - DeMichiel G
FIR - DeMichiel, G
IR  - Defilla R
FIR - Defilla, R
IR  - DiAntonio R
FIR - DiAntonio, R
IR  - DiMaria G
FIR - DiMaria, G
IR  - Dighero D
FIR - Dighero, D
IR  - Durando A
FIR - Durando, A
IR  - Fati F
FIR - Fati, F
IR  - Figone M
FIR - Figone, M
IR  - Francia R
FIR - Francia, R
IR  - Gerevini D
FIR - Gerevini, D
IR  - Granata F
FIR - Granata, F
IR  - Granelli G
FIR - Granelli, G
IR  - Guainazzo C
FIR - Guainazzo, C
IR  - Ingrassia N
FIR - Ingrassia, N
IR  - Lambruschini M
FIR - Lambruschini, M
IR  - Laurino C
FIR - Laurino, C
IR  - Leonardelli E
FIR - Leonardelli, E
IR  - Levaggi F
FIR - Levaggi, F
IR  - Levaggi M
FIR - Levaggi, M
IR  - Ligorio M
FIR - Ligorio, M
IR  - Maesani G
FIR - Maesani, G
IR  - Maggiolo G
FIR - Maggiolo, G
IR  - Malcotti A
FIR - Malcotti, A
IR  - Manno A
FIR - Manno, A
IR  - Marabotti F
FIR - Marabotti, F
IR  - Marcenaro A
FIR - Marcenaro, A
IR  - Mari M
FIR - Mari, M
IR  - Marre' E
FIR - Marre', E
IR  - Marsicani N
FIR - Marsicani, N
IR  - Massucco A
FIR - Massucco, A
IR  - Mazzini P
FIR - Mazzini, P
IR  - Mazzotti C
FIR - Mazzotti, C
IR  - Miglio L
FIR - Miglio, L
IR  - Molinari M
FIR - Molinari, M
IR  - Monteverde B
FIR - Monteverde, B
IR  - Mortola F
FIR - Mortola, F
IR  - Murroni S
FIR - Murroni, S
IR  - Ogno L
FIR - Ogno, L
IR  - Olivari M
FIR - Olivari, M
IR  - Pallavicino M
FIR - Pallavicino, M
IR  - Pellegri E
FIR - Pellegri, E
IR  - Peri M
FIR - Peri, M
IR  - Pes R
FIR - Pes, R
IR  - Pescatori R
FIR - Pescatori, R
IR  - Piaggio C
FIR - Piaggio, C
IR  - Piffero D
FIR - Piffero, D
IR  - Podesta' M
FIR - Podesta', M
IR  - Porcella E
FIR - Porcella, E
IR  - Porcu S
FIR - Porcu, S
IR  - Prato R
FIR - Prato, R
IR  - Ramasco F
FIR - Ramasco, F
IR  - Rampoldi C
FIR - Rampoldi, C
IR  - Raso S
FIR - Raso, S
IR  - Ravecca M
FIR - Ravecca, M
IR  - Ricci R
FIR - Ricci, R
IR  - Rivara A
FIR - Rivara, A
IR  - Rizzitelli G
FIR - Rizzitelli, G
IR  - Romano F
FIR - Romano, F
IR  - Romano S
FIR - Romano, S
IR  - Rottola C
FIR - Rottola, C
IR  - Ruffini G
FIR - Ruffini, G
IR  - Sambuceti D
FIR - Sambuceti, D
IR  - Sanguineti C
FIR - Sanguineti, C
IR  - Sannazzari N
FIR - Sannazzari, N
IR  - Sivori F
FIR - Sivori, F
IR  - Soave P
FIR - Soave, P
IR  - Spelta R
FIR - Spelta, R
IR  - Traversaro A
FIR - Traversaro, A
IR  - Turrin A
FIR - Turrin, A
IR  - Varese A
FIR - Varese, A
IR  - Venturini E
FIR - Venturini, E
IR  - Vignali C
FIR - Vignali, C
IR  - Zangani F
FIR - Zangani, F
IR  - Zerega R
FIR - Zerega, R
IR  - Zoccoli C
FIR - Zoccoli, C
IR  - Zunino R
FIR - Zunino, R
EDAT- 2012/07/19 06:00
MHDA- 2012/08/03 06:00
CRDT- 2012/07/19 06:00
PHST- 2012/07/19 06:00 [entrez]
PHST- 2012/07/19 06:00 [pubmed]
PHST- 2012/08/03 06:00 [medline]
PST - ppublish
SO  - J Prev Med Hyg. 2012 Mar;53(1):37-43.


PMID- 22803267
OWN - NLM
STAT- MEDLINE
DCOM- 20120731
LR  - 20191210
IS  - 0028-7571 (Print)
IS  - 0028-7571 (Linking)
VI  - 78
IP  - 3
DP  - 2012 Apr
TI  - It may be legal, but is it also ethical?
PG  - 6-8
FAU - Plunkett, Lance
AU  - Plunkett L
LA  - eng
PT  - Journal Article
PL  - United States
TA  - N Y State Dent J
JT  - The New York state dental journal
JID - 0414634
SB  - IM
CIN - N Y State Dent J. 2012 Jun-Jul;78(4):10. PMID: 23252184
MH  - Advertising/ethics/legislation & jurisprudence
MH  - Codes of Ethics
MH  - Disclosure/ethics/legislation & jurisprudence
MH  - *Ethics, Dental
MH  - Humans
MH  - New York
MH  - Societies, Dental
MH  - Whistleblowing/ethics/legislation & jurisprudence
EDAT- 2012/07/19 06:00
MHDA- 2012/08/01 06:00
CRDT- 2012/07/19 06:00
PHST- 2012/07/19 06:00 [entrez]
PHST- 2012/07/19 06:00 [pubmed]
PHST- 2012/08/01 06:00 [medline]
PST - ppublish
SO  - N Y State Dent J. 2012 Apr;78(3):6-8.


PMID- 22803022
OWN - NLM
STAT- MEDLINE
DCOM- 20120918
LR  - 20211021
IS  - 0835-7900 (Print)
IS  - 0835-7900 (Linking)
VI  - 26
IP  - 7
DP  - 2012 Jul
TI  - A Canadian Working Group report on fecal microbial therapy: microbial ecosystems 
      therapeutics.
PG  - 457-62
AB  - A working group from across Canada comprised of clinician and basic scientists,
      epidemiologists, ethicists, Health Canada regulatory authorities and
      representatives of major funding agencies (Canadian Institutes of Health Research
      and the Crohn's and Colitis Foundation of Canada) met to review the current
      experience with fecal microbial therapy and to identify the key areas of study
      required to move this field forward. The report highlights the promise of fecal
      microbial therapy and related synthetic stool therapy (together called 'microbial
      ecosystems therapeutics') for the treatment of Clostridium difficile colitis and,
      possibly, other disorders. It identifies pressing clinical issues that need to be
      addressed as well as social, ethical and regulatory barriers to the use of these 
      important therapies.
FAU - Allen-Vercoe, Emma
AU  - Allen-Vercoe E
AD  - University of Guelph, Guelph.
FAU - Reid, Gregor
AU  - Reid G
FAU - Viner, Norman
AU  - Viner N
FAU - Gloor, Gregory B
AU  - Gloor GB
FAU - Hota, Susy
AU  - Hota S
FAU - Kim, Peter
AU  - Kim P
FAU - Lee, Christine
AU  - Lee C
FAU - O'Doherty, Kieran
AU  - O'Doherty K
FAU - Vanner, Stephen J
AU  - Vanner SJ
FAU - Weese, J Scott
AU  - Weese JS
FAU - Petrof, Elaine O
AU  - Petrof EO
LA  - eng
GR  - 94314/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Canada
TA  - Can J Gastroenterol
JT  - Canadian journal of gastroenterology = Journal canadien de gastroenterologie
JID - 8807867
SB  - IM
MH  - Canada
MH  - Computational Biology
MH  - Congresses as Topic
MH  - Ecosystem
MH  - Enterocolitis, Pseudomembranous/*therapy
MH  - Feces/*microbiology
MH  - Gastroenterology/ethics/trends
MH  - Humans
MH  - Metagenome
PMC - PMC3395448
EDAT- 2012/07/18 06:00
MHDA- 2012/09/19 06:00
CRDT- 2012/07/18 06:00
PHST- 2012/07/18 06:00 [entrez]
PHST- 2012/07/18 06:00 [pubmed]
PHST- 2012/09/19 06:00 [medline]
AID - 10.1155/2012/213828 [doi]
PST - ppublish
SO  - Can J Gastroenterol. 2012 Jul;26(7):457-62. doi: 10.1155/2012/213828.


PMID- 22802983
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2035-8164 (Electronic)
IS  - 2035-8164 (Linking)
VI  - 4
IP  - 2
DP  - 2012 May 9
TI  - Multidimensional prognostic index in the elderly with hip or neck femur fracture.
PG  - e15
LID - 10.4081/or.2012.e15 [doi]
AB  - Hip and neck femur fracture surgery was associated with high post-operative
      mortality and poor functional results. The decision-making process with regards
      to the elderly with hip or neck femur fractures was of great importance,
      requiring consideration of ethical, medico legal and economic factors in addition
      to the purely medical ones. An important component in the decision-making process
      was the precise knowledge of the expected mortality. We considered here several
      articles from 1 January 2002 to 31 August 2010 that identified the possible
      scoring system to predict mortality in the elderly undergoing hip or neck femur
      fracture surgery. We found seven studies which included a total of 12,177
      patients that were assigned to hip/neck femur fracture surgery. Each study
      identified the possible scoring system to predict mortality in the elderly
      undergoing hip/neck femur fracture surgery. By reviewing the literature
      available, it was shown that there were more multidimensional prognostic indexes 
      in the elderly after hospitalization than multidimensional prognostic indexes
      with hip or neck femur fracture which could be used as a simple point scoring
      system at the bedside to predict mortality in the elderly undergoing hip or neck 
      femur fracture surgery. Although, all the prognostic indexes searched worked well
      for a general population, but they were of limited validity in the specific,
      relatively homogeneous population of hip/neck femur fracture patients.
FAU - Vitale, Elsa
AU  - Vitale E
AD  - Department of Neuroscience and Organs of Sense, Orthopedics Section, Faculty of
      Medicine and Surgery of University of Bari, General Hospital, Bari, Italy.
FAU - Notarnicola, Angela
AU  - Notarnicola A
FAU - Moretti, Lorenzo
AU  - Moretti L
FAU - Antonio, Esposito
AU  - Antonio E
FAU - Pesce, Vito
AU  - Pesce V
FAU - Moretti, Biagio
AU  - Moretti B
LA  - eng
PT  - Journal Article
DEP - 20120412
PL  - United States
TA  - Orthop Rev (Pavia)
JT  - Orthopedic reviews
JID - 101524779
PMC - PMC3395984
OTO - NOTNLM
OT  - elderly
OT  - hip fracture
OT  - neck femur fracture
OT  - orthopedic geriatric multidimensional index.
OT  - orthopedic prognostic index
EDAT- 2012/07/18 06:00
MHDA- 2012/07/18 06:01
CRDT- 2012/07/18 06:00
PHST- 2011/11/23 00:00 [received]
PHST- 2012/01/03 00:00 [revised]
PHST- 2012/01/06 00:00 [accepted]
PHST- 2012/07/18 06:00 [entrez]
PHST- 2012/07/18 06:00 [pubmed]
PHST- 2012/07/18 06:01 [medline]
AID - 10.4081/or.2012.e15 [doi]
AID - or.2012.e15 [pii]
PST - ppublish
SO  - Orthop Rev (Pavia). 2012 May 9;4(2):e15. doi: 10.4081/or.2012.e15. Epub 2012 Apr 
      12.


PMID- 22802552
OWN - NLM
STAT- MEDLINE
DCOM- 20130213
LR  - 20220321
IS  - 1440-1614 (Electronic)
IS  - 0004-8674 (Linking)
VI  - 46
IP  - 9
DP  - 2012 Sep
TI  - Ethics of giving antipsychotic medication to at-risk young people.
PG  - 908-9
LID - 10.1177/0004867412455233 [doi]
FAU - Jorm, Anthony F
AU  - Jorm AF
LA  - eng
PT  - Letter
PT  - Research Support, Non-U.S. Gov't
PT  - Comment
DEP - 20120716
PL  - England
TA  - Aust N Z J Psychiatry
JT  - The Australian and New Zealand journal of psychiatry
JID - 0111052
SB  - IM
CON - Aust N Z J Psychiatry. 2012 Apr;46(4):313-6. PMID: 22508591
MH  - Early Medical Intervention/*economics
MH  - Humans
MH  - Psychotic Disorders/*economics
EDAT- 2012/07/18 06:00
MHDA- 2013/02/14 06:00
CRDT- 2012/07/18 06:00
PHST- 2012/07/18 06:00 [entrez]
PHST- 2012/07/18 06:00 [pubmed]
PHST- 2013/02/14 06:00 [medline]
AID - 0004867412455233 [pii]
AID - 10.1177/0004867412455233 [doi]
PST - ppublish
SO  - Aust N Z J Psychiatry. 2012 Sep;46(9):908-9. doi: 10.1177/0004867412455233. Epub 
      2012 Jul 16.


PMID- 22802422
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20220129
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 4
DP  - 2012
TI  - A longitudinal qualitative exploration of healthcare and informal support needs
      among survivors of critical illness: the RELINQUISH protocol.
LID - 10.1136/bmjopen-2012-001507 [doi]
LID - e001507 [pii]
AB  - INTRODUCTION AND BACKGROUND: Survival following critical illness is associated
      with a significant burden of physical, emotional and psychosocial morbidity.
      Recovery can be protracted and incomplete, with important and sustained effects
      upon everyday life, including family life, social participation and return to
      work. In stark contrast with other critically ill patient groups (eg, those
      following cardiothoracic surgery), there are comparatively few interventional
      studies of rehabilitation among the general intensive care unit patient
      population. This paper outlines the protocol for a sub study of the RECOVER
      study: a randomised controlled trial evaluating a complex intervention of
      enhanced ward-based rehabilitation for patients following discharge from
      intensive care. METHODS AND ANALYSIS: The RELINQUISH study is a nested
      longitudinal, qualitative study of family support and perceived healthcare needs 
      among RECOVER participants at key stages of the recovery process and at up to 1
      year following hospital discharge. Its central premise is that recovery is a
      dynamic process wherein patients' needs evolve over time. RELINQUISH is novel in 
      that we will incorporate two parallel strategies into our data analysis: (1) a
      pragmatic health services-oriented approach, using an a priori analytical
      construct, the 'Timing it Right' framework and (2) a constructivist grounded
      theory approach which allows the emergence of new themes and theoretical
      understandings from the data. We will subsequently use Qualitative Health Needs
      Assessment methodology to inform the development of timely and responsive
      healthcare interventions throughout the recovery process. ETHICS AND
      DISSEMINATION: The protocol has been approved by the Lothian Research Ethics
      Committee (protocol number HSRU011). The study has been added to the UK Clinical 
      Research Network Database (study ID. 9986). The authors will disseminate the
      findings in peer reviewed publications and to relevant critical care stakeholder 
      groups.
FAU - Ramsay, Pam
AU  - Ramsay P
AD  - Department of Anaesthesia and Critical Care (Research), Royal Infirmary of
      Edinburgh, Edinburgh, UK.
FAU - Huby, Guro
AU  - Huby G
FAU - Rattray, Janice
AU  - Rattray J
FAU - Salisbury, Lisa G
AU  - Salisbury LG
FAU - Walsh, Timothy Simon
AU  - Walsh TS
FAU - Kean, Susanne
AU  - Kean S
LA  - eng
GR  - CZH/4/531/CSO_/Chief Scientist Office/United Kingdom
GR  - G0901697/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
DEP - 20120716
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3400070
EDAT- 2012/07/18 06:00
MHDA- 2012/07/18 06:01
CRDT- 2012/07/18 06:00
PHST- 2012/07/18 06:00 [entrez]
PHST- 2012/07/18 06:00 [pubmed]
PHST- 2012/07/18 06:01 [medline]
AID - bmjopen-2012-001507 [pii]
AID - 10.1136/bmjopen-2012-001507 [doi]
PST - epublish
SO  - BMJ Open. 2012 Jul 16;2(4). pii: bmjopen-2012-001507. doi:
      10.1136/bmjopen-2012-001507. Print 2012.


PMID- 22802093
OWN - NLM
STAT- MEDLINE
DCOM- 20130211
LR  - 20120917
IS  - 1460-2350 (Electronic)
IS  - 0268-1161 (Linking)
VI  - 27
IP  - 10
DP  - 2012 Oct
TI  - Implications of oocyte cryostorage for the practice of oocyte donation.
PG  - 2886-93
LID - 10.1093/humrep/des250 [doi]
AB  - As the efficiency of oocyte cryopreservation has increased rapidly in recent
      years, oocytes are currently being stored either in the course of IVF treatments 
      or as a fertility preservation measure. These practices may have an impact on the
      number of available donor oocytes due to two different dynamics: first, a certain
      percentage of women for whom oocytes were cryopreserved will eventually not use
      their oocytes and may decide to donate them to others; secondly, especially in
      the practice of social freezing, women may opt to donate a portion of the
      retrieved oocytes in 'freeze-and-share' schemes in order to reduce the costs. In 
      this article, we aim to sketch the ethical implications of such developments in
      general and the issue of payment to oocyte donors in particular.
FAU - Mertes, Heidi
AU  - Mertes H
AD  - Bioethics Institute Ghent, Ghent University, Ghent, Belgium.
      heidi.mertes@ugent.be
FAU - Pennings, Guido
AU  - Pennings G
FAU - Dondorp, Wybo
AU  - Dondorp W
FAU - de Wert, Guido
AU  - de Wert G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120715
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
SB  - IM
MH  - Adult
MH  - *Cryopreservation
MH  - Female
MH  - Fertility Preservation/economics/trends
MH  - Fertilization in Vitro/economics/trends
MH  - Humans
MH  - Oocyte Donation/economics/ethics/*trends
MH  - Tissue Donors/ethics
EDAT- 2012/07/18 06:00
MHDA- 2013/02/12 06:00
CRDT- 2012/07/18 06:00
PHST- 2012/07/18 06:00 [entrez]
PHST- 2012/07/18 06:00 [pubmed]
PHST- 2013/02/12 06:00 [medline]
AID - des250 [pii]
AID - 10.1093/humrep/des250 [doi]
PST - ppublish
SO  - Hum Reprod. 2012 Oct;27(10):2886-93. doi: 10.1093/humrep/des250. Epub 2012 Jul
      15.


PMID- 22801800
OWN - NLM
STAT- MEDLINE
DCOM- 20121105
LR  - 20181201
IS  - 1538-3660 (Electronic)
IS  - 1521-2491 (Linking)
VI  - 14
IP  - 4
DP  - 2012 Jul-Aug
TI  - Ethical conduct of humanitarian medical missions: II. use of photographic images.
PG  - 295-6
LID - 10.1001/archfacial.2011.1646 [doi]
FAU - Holt, G Richard
AU  - Holt GR
AD  - Department of Otolaryngology-Head and Neck Surgery, The University of Texas
      Health Science Center, San Antonio, TX 78258, USA. holtg@uthscsa.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Arch Facial Plast Surg
JT  - Archives of facial plastic surgery
JID - 100883500
SB  - IM
MH  - *Altruism
MH  - Attitude of Health Personnel
MH  - Cross-Cultural Comparison
MH  - *Delivery of Health Care
MH  - Ethics, Medical
MH  - Humans
MH  - Medical Missions/*ethics
MH  - *Photography
MH  - Physician-Patient Relations
EDAT- 2012/07/18 06:00
MHDA- 2012/11/06 06:00
CRDT- 2012/07/18 06:00
PHST- 2012/07/18 06:00 [entrez]
PHST- 2012/07/18 06:00 [pubmed]
PHST- 2012/11/06 06:00 [medline]
AID - 1214561 [pii]
AID - 10.1001/archfacial.2011.1646 [doi]
PST - ppublish
SO  - Arch Facial Plast Surg. 2012 Jul-Aug;14(4):295-6. doi:
      10.1001/archfacial.2011.1646.


PMID- 22801468
OWN - NLM
STAT- MEDLINE
DCOM- 20130107
LR  - 20120815
IS  - 1751-4266 (Electronic)
IS  - 1751-4258 (Linking)
VI  - 6
IP  - 3
DP  - 2012 Sep
TI  - Is there a role for parenteral nutrition or hydration at the end of life?
PG  - 365-70
LID - 10.1097/SPC.0b013e328356ab4a [doi]
AB  - PURPOSE OF REVIEW: This review aims to update healthcare providers on the role of
      parenteral nutrition/hydration in terminal patients and highlight recent
      research. RECENT FINDINGS: Cachexia is felt to be refractory to treatment at the 
      last stages of life. The majority of terminally ill patients will derive no
      benefit from parenteral nutrition with some exceptions including patients with a 
      good functional status and a nonfunctional gastrointestinal tract or a slow
      growing tumor.Dehydration can potentially be reversible in patients at the end of
      life. However, recent research examining parenteral hydration reveals no clear
      clinical benefits on symptom burden or survival for terminally ill cancer
      patients with the exception of possibly reversing the complication of delirium.
      SUMMARY: Hydration and nutrition are essential for the maintenance of life. In
      patients at the end of life, artificial hydration and nutrition pose clinical,
      ethical, and logistical dilemmas. No strong evidence exists supporting the use of
      parenteral hydration/nutrition for the majority of terminally ill patients;
      however, a subset of patients may derive some benefit. Uncertainty about
      determining prognosis, psychosocial factors, and perceptions of perceived
      benefits results in artificial nutrition/hydration being initiated in terminally 
      ill patients. Discontinuation of artificial support can result in distress for
      patients, family members, and healthcare providers.
FAU - Dev, Rony
AU  - Dev R
AD  - Department of Palliative Care and Rehabilitation Medicine, University of Texas MD
      Anderson Cancer Center, Houston, Texas, USA.
FAU - Dalal, Shalini
AU  - Dalal S
FAU - Bruera, Eduardo
AU  - Bruera E
LA  - eng
GR  - R01CA122292-01/CA/NCI NIH HHS/United States
GR  - R01CA124481-01/CA/NCI NIH HHS/United States
GR  - R0NR010162-01A1/NR/NINR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United States
TA  - Curr Opin Support Palliat Care
JT  - Current opinion in supportive and palliative care
JID - 101297402
SB  - IM
MH  - Cachexia/*therapy
MH  - Decision Making
MH  - Dehydration/*therapy
MH  - *Fluid Therapy
MH  - Humans
MH  - Nutritional Status
MH  - Palliative Care/*methods
MH  - Parenteral Nutrition/*methods
MH  - Terminal Care/*methods
EDAT- 2012/07/18 06:00
MHDA- 2013/01/08 06:00
CRDT- 2012/07/18 06:00
PHST- 2012/07/18 06:00 [entrez]
PHST- 2012/07/18 06:00 [pubmed]
PHST- 2013/01/08 06:00 [medline]
AID - 10.1097/SPC.0b013e328356ab4a [doi]
PST - ppublish
SO  - Curr Opin Support Palliat Care. 2012 Sep;6(3):365-70. doi:
      10.1097/SPC.0b013e328356ab4a.


PMID- 22801358
OWN - NLM
STAT- MEDLINE
DCOM- 20121127
LR  - 20151119
IS  - 1473-6578 (Electronic)
IS  - 0951-7367 (Linking)
VI  - 25
IP  - 5
DP  - 2012 Sep
TI  - Sexual disorders and crime.
PG  - 370-4
LID - 10.1097/YCO.0b013e328356b7d9 [doi]
AB  - PURPOSE OF REVIEW: Highlighting the relationship between sexual disorders and
      crime, reviewing and summarizing the articles published throughout 2011 which add
      to the current knowledge on this subject. RECENT FINDINGS: Studies on specific
      populations confirm the association between sexual disorders and crime,
      particularly between paraphilias and sexual crimes regarding male offenders.
      Female offenders are less likely to be diagnosed with a sexual disorder. Some
      case reports focus on unusual paraphilias and lead us to question the vast
      possibilities of paraphilic contents and sexual arousal patterns. The variations 
      of paraphilic-associated sexual arousal patterns, unconventional sex behaviors or
      paraphilic disorders are constantly changing. In this sense, the American
      Psychiatric Association's DSM-5 current proposals for a sexual dysfunction
      diagnostic category are under intense discussion because of their important
      clinical and forensic consequences. SUMMARY: Sexual violence is a theme not well 
      understood yet. Because of its nature, researching it can raise many ethical
      problems. There is no possibility of clinical trials and of case-control studies.
      Even cohort studies may be problematic in themselves. So, most of the research
      involves biased samples or case reports, or is merely theoretical. Further
      research is needed to improve our understanding of the subject, so that
      preventive and rehabilitative measures can be taken.
FAU - Taborda, Jose G V
AU  - Taborda JG
AD  - Department of Clinical Medicine, Federal University of Health Sciences of Porto
      Alegre, UFCSPA, Porto Alegre, Rio Grande do Sul, Brazil. jose@taborda.med.br
FAU - Michalski-Jaeger, Camila A
AU  - Michalski-Jaeger CA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Curr Opin Psychiatry
JT  - Current opinion in psychiatry
JID - 8809880
SB  - IM
MH  - Criminal Psychology
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Female
MH  - Humans
MH  - Male
MH  - Paraphilic Disorders/diagnosis/*psychology
MH  - Sex Offenses/prevention & control/*psychology
MH  - Sexual Behavior/psychology
EDAT- 2012/07/18 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/18 06:00
PHST- 2012/07/18 06:00 [entrez]
PHST- 2012/07/18 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1097/YCO.0b013e328356b7d9 [doi]
PST - ppublish
SO  - Curr Opin Psychiatry. 2012 Sep;25(5):370-4. doi: 10.1097/YCO.0b013e328356b7d9.


PMID- 22800776
OWN - NLM
STAT- MEDLINE
DCOM- 20140114
LR  - 20120717
IS  - 0529-5815 (Print)
IS  - 0529-5815 (Linking)
VI  - 50
IP  - 4
DP  - 2012 Apr
TI  - [Legal and ethical thinking of total thyroidectomy].
PG  - 292-3
FAU - Ji, Guang-wei
AU  - Ji GW
AD  - dr.jgw@163.com
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Wai Ke Za Zhi
JT  - Zhonghua wai ke za zhi [Chinese journal of surgery]
JID - 0153611
SB  - IM
MH  - Humans
MH  - Thyroidectomy/*ethics/*legislation & jurisprudence
EDAT- 2012/07/18 06:00
MHDA- 2014/01/15 06:00
CRDT- 2012/07/18 06:00
PHST- 2012/07/18 06:00 [entrez]
PHST- 2012/07/18 06:00 [pubmed]
PHST- 2014/01/15 06:00 [medline]
PST - ppublish
SO  - Zhonghua Wai Ke Za Zhi. 2012 Apr;50(4):292-3.


PMID- 22800564
OWN - NLM
STAT- MEDLINE
DCOM- 20130124
LR  - 20161125
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 222
DP  - 2012 Oct 11
TI  - The synergistic effect of beta-boswellic acid and Nurr1 overexpression on
      dopaminergic programming of antioxidant glutathione peroxidase-1-expressing
      murine embryonic stem cells.
PG  - 404-16
LID - 10.1016/j.neuroscience.2012.07.009 [doi]
AB  - Parkinson's disease (PD) is a neurodegenerative disorder in which the
      nigro-striatal dopaminergic (DAergic) neurons have been selectively lost. Due to 
      side effects of levodopa, a dopamine precursor drug, recently cell replacement
      therapy for PD has been considered. Lack of sufficient amounts of, embryos and
      ethical problems regarding the use of dopamine-rich embryonic neural cells have
      limited the application of these cells for PD cell therapy. Therefore, many
      investigators have focused on using the pluripotent stem cells to generate
      DAergic neurons. This study is aimed first to establish a mouse embryonic stem
      (mES) cell line that can stably co-express Nurr1 (Nuclear receptor subfamily 4,
      group A, member 2) transcription factor in order to efficiently generate DAergic 
      neurons, and glutathione peroxidase-1 (GPX-1) to protect the differentiated
      DAergic-like cells against oxidative stress. In addition to genetic engineering
      of ES cells, the effect of Beta-boswellic acid (BBA) on DAergic differentiation
      course of mES cells was sought in the present study. To that end, the
      feeder-independent CGR8 mouse embryonic stem cells were transduced by Nurr1- and 
      GPX-1-harboring Lentiviruses and the generated Nurr1/GPX-1-expresssing ES clones 
      were characterized and verified. Gene expression analyses demonstrated that BBA
      treatment and overexpression of Nurr1 has a synergistic effect on derivation of
      DAergic neurons from Nurr1/GPX-1-expressing ES cells. The differentiated cells
      could exclusively synthesize and secrete dopamine in response to stimuli.
      Overexpression of GPX-1 in genetically engineered Nurr1/GPX-1-ES cells increased 
      the viability of these cells during their differentiation into CNS stem cells. In
      conclusion, the results demonstrated that Nurr1-overexpressing feeder-independent
      ES cells like the feeder-dependent ES cells, can be efficiently programmed into
      functional DAergic neurons and additional treatment of cells by BBA can even
      augment this efficiency. GPX-1 overexpression in Nurr1/GPX-1-ES cells increases
      the viability of differentiated CNS stem-like cells. The result of this study may
      have impact on future stem cell therapy of PD.
CI  - Copyright (c) 2012 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Abasi, M
AU  - Abasi M
AD  - Division of Medical Biotechnology, National Institute for Genetic Engineering and
      Biotechnology, Tehran, Iran.
FAU - Massumi, M
AU  - Massumi M
FAU - Riazi, G
AU  - Riazi G
FAU - Amini, H
AU  - Amini H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120716
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Antioxidants)
RN  - 0 (Nr4a2 protein, mouse)
RN  - 0 (Nuclear Receptor Subfamily 4, Group A, Member 2)
RN  - 0 (RNA, Messenger)
RN  - 0 (Tetrazolium Salts)
RN  - 0 (Thiazoles)
RN  - 0 (Triterpenes)
RN  - 631-69-6 (boswellic acid)
RN  - EC 1.11.1.- (glutathione peroxidase GPX1)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EUY85H477I (thiazolyl blue)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Animals, Genetically Modified
MH  - Antioxidants/*metabolism
MH  - Cell Differentiation
MH  - Chromatography, High Pressure Liquid
MH  - Dopamine/*physiology
MH  - Dopaminergic Neurons/physiology
MH  - Embryonic Stem Cells/drug effects/*metabolism
MH  - Glutathione Peroxidase/*biosynthesis/genetics
MH  - Humans
MH  - Immunohistochemistry
MH  - Induced Pluripotent Stem Cells
MH  - Lentivirus/genetics
MH  - Mice
MH  - Nuclear Receptor Subfamily 4, Group A, Member 2/biosynthesis/genetics/*physiology
MH  - Phenotype
MH  - RNA, Messenger/biosynthesis/genetics
MH  - Tetrazolium Salts
MH  - Thiazoles
MH  - Transfection
MH  - Triterpenes/*pharmacology
EDAT- 2012/07/18 06:00
MHDA- 2013/01/25 06:00
CRDT- 2012/07/18 06:00
PHST- 2012/02/13 00:00 [received]
PHST- 2012/07/05 00:00 [revised]
PHST- 2012/07/05 00:00 [accepted]
PHST- 2012/07/18 06:00 [entrez]
PHST- 2012/07/18 06:00 [pubmed]
PHST- 2013/01/25 06:00 [medline]
AID - S0306-4522(12)00714-2 [pii]
AID - 10.1016/j.neuroscience.2012.07.009 [doi]
PST - ppublish
SO  - Neuroscience. 2012 Oct 11;222:404-16. doi: 10.1016/j.neuroscience.2012.07.009.
      Epub 2012 Jul 16.


PMID- 22800405
OWN - NLM
STAT- MEDLINE
DCOM- 20120911
LR  - 20120807
IS  - 0098-9134 (Print)
IS  - 0098-9134 (Linking)
VI  - 38
IP  - 8
DP  - 2012 Aug
TI  - Covert medication administration: the practice of hiding medications in long-term
      care settings.
PG  - 14-20
LID - 10.3928/00989134-20120703-06 [doi]
AB  - Covert medication administration is the purposeful hiding of medications from
      patients, and the topic receives little attention. Awareness and research
      regarding this practice is limited to a handful of studies outside of the United 
      States. These studies suggest a larger prevalence than reported and identify
      significant ethical and legal implications for bedside nurses. A review of the
      literature, discussion of prevalence, contributing factors, and potential
      consequences of this practice build the foundation for practice recommendations
      and suggestions for future research. In addition to recommendations for nurses
      regarding covert medication administration, additional research and exploration
      of this issue in the United States are proposed.
CI  - Copyright 2012, SLACK Incorporated.
FAU - Farrar, Helen M
AU  - Farrar HM
AD  - Center of Geriatric Nursing Excellence, University of Oklahoma, Oklahoma City,
      OK, USA. Helen-farrar@ouhsc.edu
FAU - Stewart, Carol
AU  - Stewart C
FAU - Sturdevant, Diana
AU  - Sturdevant D
LA  - eng
PT  - Journal Article
DEP - 20120715
PL  - United States
TA  - J Gerontol Nurs
JT  - Journal of gerontological nursing
JID - 7510258
MH  - Drug Therapy/*methods
MH  - Education, Nursing, Continuing
MH  - Ethics
MH  - Guidelines as Topic
MH  - Long-Term Care
MH  - Nursing Homes/*organization & administration
MH  - *Nursing Staff
MH  - Prevalence
MH  - United States
EDAT- 2012/07/18 06:00
MHDA- 2012/09/12 06:00
CRDT- 2012/07/18 06:00
PHST- 2011/08/27 00:00 [received]
PHST- 2012/03/14 00:00 [accepted]
PHST- 2012/07/18 06:00 [entrez]
PHST- 2012/07/18 06:00 [pubmed]
PHST- 2012/09/12 06:00 [medline]
AID - 10.3928/00989134-20120703-06 [doi]
PST - ppublish
SO  - J Gerontol Nurs. 2012 Aug;38(8):14-20. doi: 10.3928/00989134-20120703-06. Epub
      2012 Jul 15.


PMID- 22800101
OWN - NLM
STAT- MEDLINE
DCOM- 20130205
LR  - 20181201
IS  - 1935-990X (Electronic)
IS  - 0003-066X (Linking)
VI  - 67
IP  - 5
DP  - 2012 Jul-Aug
TI  - Psychology and social justice: why we do what we do.
PG  - 337-46
LID - 10.1037/a0029232 [doi]
AB  - Much of psychological science and knowledge is significantly relevant to social
      justice, defined here as the goal to decrease human suffering and to promote
      human values of equality and justice. A commitment to social justice has evolved 
      as a more important value in the last few decades for psychology, including for
      the American Psychological Association (APA). The mission, vision, goals, Ethics 
      Code, and strategic plan of APA all provide a rationale for psychologists'
      involvement in systematic and visible ways of applying our knowledge to social
      issues. Although psychology has not been immune to the application of
      psychological knowledge in destructive ways, overall, psychology, many
      psychologists, and APA have demonstrated a commitment to social justice. This
      article provides a brief review of the key proponents, debates, and controversies
      involved in applying psychological science and knowledge to complex societal
      problems. Psychologists often find themselves in conflict and honest disagreement
      when the association addresses complex and controversial issues. An important
      goal is that we continue to find ways to agree or disagree in a respectful manner
      regardless of where each of us stands on the various positions that APA takes.
FAU - Vasquez, Melba J T
AU  - Vasquez MJ
AD  - Anderson House at Heritage Square, 2901 Bee Cave Road, Box N, Austin, TX 78746,
      USA. melvasquez@aol.com
LA  - eng
PT  - Address
PL  - United States
TA  - Am Psychol
JT  - The American psychologist
JID - 0370521
SB  - IM
CIN - Am Psychol. 2013 Sep;68(6):475-6. PMID: 24016125
MH  - Codes of Ethics
MH  - Humans
MH  - Psychology/*ethics
MH  - *Social Justice
MH  - *Societies, Scientific
EDAT- 2012/07/18 06:00
MHDA- 2013/02/06 06:00
CRDT- 2012/07/18 06:00
PHST- 2012/07/18 06:00 [entrez]
PHST- 2012/07/18 06:00 [pubmed]
PHST- 2013/02/06 06:00 [medline]
AID - 2012-18676-002 [pii]
AID - 10.1037/a0029232 [doi]
PST - ppublish
SO  - Am Psychol. 2012 Jul-Aug;67(5):337-46. doi: 10.1037/a0029232.


PMID- 22799544
OWN - NLM
STAT- MEDLINE
DCOM- 20130403
LR  - 20151119
IS  - 2153-2176 (Electronic)
IS  - 2153-2168 (Linking)
VI  - 8
IP  - 3
DP  - 2012 Jun
TI  - Marketing foods to children: are we asking the right questions?
PG  - 191-4
LID - 10.1089/chi.2012.0013 [doi]
AB  - The childhood obesity epidemic has prompted a range of regulatory initiatives
      that seek to reduce the impact of food marketing on children. Policy
      recommendations by government and public health organizations have suggested
      regulating the promotion of high-sugar, -fat, and/or -salt foods to children,
      while the food industry has created voluntary nutrition guidelines to channel
      child-targeted marketing toward only "better-for-you" products. This article
      argues that the overarching focus on the nutrient profile of foods (nutritionism)
      is wrong-headed: The slippage in terms from "better-for-you" foods to "healthy
      dietary choices" is problematic and also makes it difficult for children to
      identify the healthy choice. Nutritionism further works to sidestep important
      questions pertaining to the ethics of food marketing, not to mention the way that
      marketing foods as fun and entertainment works to encourage overeating in
      children.
FAU - Elliott, Charlene
AU  - Elliott C
AD  - Department of Communication and Culture, Faculty of Arts, University of Calgary, 
      Calgary, Alberta, Canada. celliott@ucalgary.ca
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Child Obes
JT  - Childhood obesity (Print)
JID - 101542497
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Energy Intake
MH  - Food
MH  - Food Industry/*ethics
MH  - Food, Organic
MH  - Humans
MH  - Marketing/*ethics
MH  - Nutrition Policy/*legislation & jurisprudence
MH  - Nutritive Value
MH  - Overweight/prevention & control
MH  - Persuasive Communication
EDAT- 2012/07/18 06:00
MHDA- 2013/04/04 06:00
CRDT- 2012/07/18 06:00
PHST- 2012/07/18 06:00 [entrez]
PHST- 2012/07/18 06:00 [pubmed]
PHST- 2013/04/04 06:00 [medline]
AID - 10.1089/chi.2012.0013 [doi]
PST - ppublish
SO  - Child Obes. 2012 Jun;8(3):191-4. doi: 10.1089/chi.2012.0013.


PMID- 22798191
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20211021
IS  - 1573-0980 (Electronic)
IS  - 1386-7415 (Linking)
VI  - 33
IP  - 4
DP  - 2012 Aug
TI  - Quality of life is a process not an outcome.
PG  - 279-92
LID - 10.1007/s11017-012-9227-z [doi]
AB  - Quality improvement mechanisms increasingly use outcome measures to evaluate
      health care providers. This move toward outcome measures is a radical departure
      from the traditional focus on process measures. More radical still is the
      proposal to shift from relatively simple and proximal measures of outcome, such
      as mortality, to complex outcomes, such as quality of life. While the practical, 
      scientific, and ethical issues associated with the use of outcomes such as
      mortality and morbidity to compare health care providers have been well
      rehearsed, the specific concerns associated with the use of quality of life
      measures in quality of care research have received little attention. As with much
      research on quality of life there is a tendency to assume that the disadvantages 
      are outweighed by the general virtue of "listening" to patients. In this paper we
      disagree with this assumption and argue that quality of life is a process, not an
      outcome.
FAU - McClimans, Leah
AU  - McClimans L
AD  - Department of Philosophy, University of South Carolina, Columbia, SC 29208, USA. 
      mccliman@mailbox.sc.edu
FAU - Browne, John P
AU  - Browne JP
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Theor Med Bioeth
JT  - Theoretical medicine and bioethics
JID - 9805378
SB  - IM
MH  - Bioethics
MH  - Ethical Theory
MH  - Humans
MH  - National Health Programs/*standards/trends
MH  - Outcome Assessment, Health Care
MH  - *Patient Satisfaction
MH  - *Process Assessment, Health Care
MH  - Quality Indicators, Health Care
MH  - Quality of Health Care
MH  - *Quality of Life
MH  - Social Justice
MH  - United Kingdom
MH  - United States
EDAT- 2012/07/17 06:00
MHDA- 2012/11/14 06:00
CRDT- 2012/07/17 06:00
PHST- 2012/07/17 06:00 [entrez]
PHST- 2012/07/17 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
AID - 10.1007/s11017-012-9227-z [doi]
PST - ppublish
SO  - Theor Med Bioeth. 2012 Aug;33(4):279-92. doi: 10.1007/s11017-012-9227-z.


PMID- 22796846
OWN - NLM
STAT- MEDLINE
DCOM- 20121101
LR  - 20220318
IS  - 1931-3543 (Electronic)
IS  - 0012-3692 (Linking)
VI  - 142
IP  - 1
DP  - 2012 Jul
TI  - Biomarkers of sleep apnea.
PG  - 239-245
LID - S0012-3692(12)60412-7 [pii]
LID - 10.1378/chest.11-2322 [doi]
AB  - Obstructive sleep apnea (OSA) is a condition of repetitive upper airway collapse,
      which occurs during sleep. Recent literature has emphasized the role of OSA in
      contributing to glucose intolerance, dyslipidemia, and hypertension. OSA is
      associated with the development of cardiovascular disease, although definitive
      data are sparse with regard to the prevention of cardiovascular disease and CPAP 
      therapy. CPAP provides effective treatment for OSA, but patient adherence remains
      challenging. Aside from daytime symptom improvement, it is difficult to monitor
      the adequacy of treatment response. Thus, the search for a biomarker becomes
      critical. The discovery of an ideal biomarker for OSA has the potential to
      provide information related to diagnosis, severity, prognosis, and response to
      treatment. In addition, because large-scale randomized controlled trials are both
      ethically and logistically challenging in assessing hard cardiovascular outcomes,
      certain biomarkers may be reasonable surrogate outcome measures. This article
      reviews the literature related to potential biomarkers of OSA with the
      recognition that an ideal biomarker does not exist at this time.
FAU - Montesi, Sydney B
AU  - Montesi SB
AD  - Department of Pulmonary and Critical Care Medicine, Massachusetts General
      Hospital, Boston, MA. Electronic address: sbmontesi@partners.org.
FAU - Bajwa, Ednan K
AU  - Bajwa EK
AD  - Department of Pulmonary and Critical Care Medicine, Massachusetts General
      Hospital, Boston, MA.
FAU - Malhotra, Atul
AU  - Malhotra A
AD  - Department of Sleep Medicine, Brigham and Women's Hospital, Boston, MA.
LA  - eng
GR  - R01 HL090897/HL/NHLBI NIH HHS/United States
GR  - R01 HL085188/HL/NHLBI NIH HHS/United States
GR  - R01 AG035117/AG/NIA NIH HHS/United States
GR  - K23 HL087934/HL/NHLBI NIH HHS/United States
GR  - K24 HL093218/HL/NHLBI NIH HHS/United States
GR  - P01 HL095491/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Chest
JT  - Chest
JID - 0231335
RN  - 0 (Biomarkers)
SB  - IM
MH  - Biomarkers/metabolism
MH  - Continuous Positive Airway Pressure
MH  - Humans
MH  - Outcome Assessment, Health Care
MH  - Prognosis
MH  - *Severity of Illness Index
MH  - Sleep Apnea, Obstructive/*diagnosis/*metabolism/therapy
PMC - PMC3418859
EDAT- 2012/07/17 06:00
MHDA- 2012/11/02 06:00
CRDT- 2012/07/17 06:00
PHST- 2012/07/17 06:00 [entrez]
PHST- 2012/07/17 06:00 [pubmed]
PHST- 2012/11/02 06:00 [medline]
AID - S0012-3692(12)60412-7 [pii]
AID - 10.1378/chest.11-2322 [doi]
PST - ppublish
SO  - Chest. 2012 Jul;142(1):239-245. doi: 10.1378/chest.11-2322.


PMID- 22796051
OWN - NLM
STAT- MEDLINE
DCOM- 20130410
LR  - 20181202
IS  - 1879-0429 (Electronic)
IS  - 0958-1669 (Linking)
VI  - 23
IP  - 6
DP  - 2012 Dec
TI  - Animal production for efficient phosphate utilization: from optimized feed to
      high efficiency livestock.
PG  - 872-7
LID - 10.1016/j.copbio.2012.06.001 [doi]
LID - S0958-1669(12)00094-8 [pii]
AB  - Phosphorus (P) is an essential nutrient for livestock but its efficiency of
      utilization is below 40%, contributing to environmental issues. In this review,
      we summarize recent approaches to optimize P availability in livestock diets and 
      improve its utilization efficiency. Phase feeding could potentially reduce P
      excretion by 20%. Addition of phytase enzymes to diets increased P availability
      from 42 to 95%. Low phytate transgenic plants and transgenic animals increased P 
      availability by 14% and 52-99%, respectively. In practice, a combination of phase
      feeding and enzymes has the highest potential for P reduction but legislation and
      ethics implications will prevent using transgenic animals in the short term.
      Functional and nutritional genomics may provide tools to improve efficiency in
      the future.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Kebreab, Ermias
AU  - Kebreab E
AD  - Department of Animal Science, University of California, Davis, Davis, CA 95616,
      USA. ekebreab@ucdavis.edu
FAU - Hansen, Anja V
AU  - Hansen AV
FAU - Strathe, Anders B
AU  - Strathe AB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120714
PL  - England
TA  - Curr Opin Biotechnol
JT  - Current opinion in biotechnology
JID - 9100492
RN  - 0 (Phosphates)
RN  - 0 (Phosphorus, Dietary)
RN  - 7IGF0S7R8I (Phytic Acid)
RN  - EC 3.1.3.26 (6-Phytase)
SB  - IM
MH  - 6-Phytase/administration & dosage/genetics/*metabolism
MH  - Animal Feed/*analysis
MH  - Animals
MH  - Animals, Genetically Modified
MH  - Diet/methods/*veterinary
MH  - Genomics
MH  - Livestock/genetics/*metabolism
MH  - Phosphates/*metabolism
MH  - Phosphorus, Dietary/*metabolism/supply & distribution
MH  - Phytic Acid/metabolism
EDAT- 2012/07/17 06:00
MHDA- 2013/04/11 06:00
CRDT- 2012/07/17 06:00
PHST- 2012/01/29 00:00 [received]
PHST- 2012/06/05 00:00 [revised]
PHST- 2012/06/14 00:00 [accepted]
PHST- 2012/07/17 06:00 [entrez]
PHST- 2012/07/17 06:00 [pubmed]
PHST- 2013/04/11 06:00 [medline]
AID - S0958-1669(12)00094-8 [pii]
AID - 10.1016/j.copbio.2012.06.001 [doi]
PST - ppublish
SO  - Curr Opin Biotechnol. 2012 Dec;23(6):872-7. doi: 10.1016/j.copbio.2012.06.001.
      Epub 2012 Jul 14.


PMID- 22795981
OWN - NLM
STAT- MEDLINE
DCOM- 20130214
LR  - 20130502
IS  - 1873-4588 (Electronic)
IS  - 0892-1997 (Linking)
VI  - 26
IP  - 5
DP  - 2012 Sep
TI  - Regenerative medicine of the larynx. Where are we today? A review.
PG  - 670.e7-13
LID - 10.1016/j.jvoice.2012.03.009 [doi]
AB  - Tissue engineering is a multidimensional process combining cells, scaffold
      matrices, and chemical signals to produce a structure similar to a target tissue.
      These techniques have opened a completely new field in diagnosis and therapy in
      numerous fields, including that of laryngology. Laryngeal tissue engineering has 
      emerged in the last decade, although clinical applications are rare. The reasons 
      therefore are numerous including ethical reasons, as well as the extremely
      complex anatomical structure of the vocal fold. The search for new treatment
      options has also enlarged our knowledge about the microphysiology and
      micropathophysiology of the vocal fold. To date, only specific growth factors are
      in clinical use for treatment of vocal fold atrophy. Big advances have been made 
      in creating state-of-the-art scaffolds with various techniques including
      biomaterials as well as fully synthetic polymers. These scaffolds are supposed to
      provide an optimal environment for residual or implanted cells. Several in vitro 
      settings showed practicability of these scaffolds, also in studying effects of
      growth factors. Cell therapy is a powerful tool in regenerative medicine but
      bears the uncertainty of possible malignant transformation. The aim of this
      review was to give a comprehensive overview about current knowledge in the field 
      of laryngeal tissue engineering and regenerative medicine, including restoration 
      of both vocal folds and laryngeal cartilage, and furthermore to elucidate further
      trends in this fascinating field.
CI  - Copyright (c) 2012 The Voice Foundation. Published by Mosby, Inc. All rights
      reserved.
FAU - Gugatschka, Markus
AU  - Gugatschka M
AD  - Department of Phoniatrics, ENT University Hospital Graz, Medical University Graz,
      Graz, Austria. markus.gugatschka@klinikum-graz.at
FAU - Ohno, Satoshi
AU  - Ohno S
FAU - Saxena, Amulya
AU  - Saxena A
FAU - Hirano, Shigeru
AU  - Hirano S
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120713
PL  - United States
TA  - J Voice
JT  - Journal of voice : official journal of the Voice Foundation
JID - 8712262
RN  - 0 (Intercellular Signaling Peptides and Proteins)
SB  - IM
MH  - Animals
MH  - *Cell Transplantation
MH  - Genetic Therapy
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins/biosynthesis/genetics/therapeutic
      use
MH  - Laryngeal Diseases/genetics/metabolism/pathology/physiopathology/*surgery
MH  - Larynx/metabolism/pathology/physiopathology/*surgery
MH  - *Regeneration
MH  - Regenerative Medicine/*methods
MH  - *Tissue Engineering
MH  - Tissue Scaffolds
MH  - Treatment Outcome
EDAT- 2012/07/17 06:00
MHDA- 2013/02/15 06:00
CRDT- 2012/07/17 06:00
PHST- 2011/08/08 00:00 [received]
PHST- 2012/03/20 00:00 [accepted]
PHST- 2012/07/17 06:00 [entrez]
PHST- 2012/07/17 06:00 [pubmed]
PHST- 2013/02/15 06:00 [medline]
AID - S0892-1997(12)00043-4 [pii]
AID - 10.1016/j.jvoice.2012.03.009 [doi]
PST - ppublish
SO  - J Voice. 2012 Sep;26(5):670.e7-13. doi: 10.1016/j.jvoice.2012.03.009. Epub 2012
      Jul 13.


PMID- 22795743
OWN - NLM
STAT- MEDLINE
DCOM- 20150925
LR  - 20151119
IS  - 1532-2793 (Electronic)
IS  - 0260-6917 (Linking)
VI  - 33
IP  - 10
DP  - 2013 Oct
TI  - Moral judgment competence of nursing students in the Czech Republic.
PG  - 1201-6
LID - 10.1016/j.nedt.2012.06.016 [doi]
LID - S0260-6917(12)00205-5 [pii]
AB  - The aim of this cross-sectional study was to determine the level of moral
      judgment competence in students of nursing at the University of Ostrava Faculty
      of Medicine, and whether it is influenced by the field of study, type of study,
      current year of study and age. The design of the study was cross-sectional. The
      survey sample comprised 662 full-time and part-time students of General Nursing
      and Midwifery. To measure ethical competence, Lind's Moral Judgment Test (MJT,
      1995) was used. The nursing students showed low C-index scores (the mean C-index 
      was 14.24 +/- 9.56). The C-index was significantly influenced only by the type of
      study and age (p<0.05). Part-time students and those over 30 years of age had the
      lowest C-index scores. On average, the students preferred stages 5 and 6 of moral
      judgment, that is the post-conventional level. Due to the nursing students' lower
      C-index scores, methods developing ethical argumentation should be introduced
      into nursing ethics courses.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Buzgova, Radka
AU  - Buzgova R
AD  - Department of Nursing and Midwifery, Medical Faculty, University of Ostrava,
      Czech Republic. Electronic address: radka.buzgova@osu.cz.
FAU - Sikorova, Lucie
AU  - Sikorova L
LA  - eng
PT  - Journal Article
DEP - 20120713
PL  - Scotland
TA  - Nurse Educ Today
JT  - Nurse education today
JID - 8511379
MH  - Adult
MH  - Age Factors
MH  - Cross-Sectional Studies
MH  - Czech Republic
MH  - *Ethics, Nursing
MH  - Female
MH  - Humans
MH  - *Judgment
MH  - Male
MH  - Middle Aged
MH  - *Morals
MH  - Students, Nursing/*psychology
MH  - Surveys and Questionnaires
OTO - NOTNLM
OT  - Attitudes
OT  - Euthanasia
OT  - Moral competence
OT  - Moral judgment test
OT  - Nursing students
EDAT- 2012/07/17 06:00
MHDA- 2015/09/26 06:00
CRDT- 2012/07/17 06:00
PHST- 2012/03/06 00:00 [received]
PHST- 2012/06/04 00:00 [revised]
PHST- 2012/06/14 00:00 [accepted]
PHST- 2012/07/17 06:00 [entrez]
PHST- 2012/07/17 06:00 [pubmed]
PHST- 2015/09/26 06:00 [medline]
AID - S0260-6917(12)00205-5 [pii]
AID - 10.1016/j.nedt.2012.06.016 [doi]
PST - ppublish
SO  - Nurse Educ Today. 2013 Oct;33(10):1201-6. doi: 10.1016/j.nedt.2012.06.016. Epub
      2012 Jul 13.


PMID- 22795681
OWN - NLM
STAT- MEDLINE
DCOM- 20121210
LR  - 20121001
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 98
IP  - 4
DP  - 2012 Oct
TI  - Human somatic cell nuclear transfer and cloning.
PG  - 804-7
LID - 10.1016/j.fertnstert.2012.06.045 [doi]
LID - S0015-0282(12)00698-X [pii]
AB  - This document presents arguments that conclude that it is unethical to use
      somatic cell nuclear transfer (SCNT) for infertility treatment due to concerns
      about safety; the unknown impact of SCNT on children, families, and society; and 
      the availability of other ethically acceptable means of assisted reproduction.
      This document replaces the ASRM Ethics Committee report titled, "Human somatic
      cell nuclear transfer (cloning)," last published in Fertil Steril 2000;74:873-6.
CI  - Copyright (c) 2012 American Society for Reproductive Medicine. Published by
      Elsevier Inc. All rights reserved.
CN  - Ethics Committee of the American Society for Reproductive Medicine
LA  - eng
PT  - Journal Article
DEP - 20120712
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
SB  - IM
MH  - Animals
MH  - Cloning, Organism/*ethics
MH  - Education, Medical, Continuing
MH  - Ethics Committees/ethics
MH  - Female
MH  - Humans
MH  - Infertility/*therapy
MH  - Nuclear Transfer Techniques/*ethics
MH  - Pregnancy
MH  - Reproductive Techniques, Assisted/*ethics
MH  - Social Values
IR  - Amato P
FIR - Amato, Paula
IR  - Brzyski R
FIR - Brzyski, Robert
IR  - Braverman A
FIR - Braverman, Andrea
IR  - Benward J
FIR - Benward, Jean
IR  - Stein A
FIR - Stein, Andrea
IR  - Steinbock B
FIR - Steinbock, Bonnie
IR  - Wilder B
FIR - Wilder, Bruce
IR  - Lamb D
FIR - Lamb, Dolores
IR  - Reindollar R
FIR - Reindollar, Richard
IR  - Robertson J
FIR - Robertson, John
IR  - Daar J
FIR - Daar, Judith
IR  - Francis L
FIR - Francis, Leslie
IR  - Gibson M
FIR - Gibson, Mark
IR  - Rebar R
FIR - Rebar, Robert
IR  - Tipton S
FIR - Tipton, Sean
IR  - Fisseha S
FIR - Fisseha, Senait
IR  - Ralston S
FIR - Ralston, Steven
IR  - Spillman M
FIR - Spillman, Monique
EDAT- 2012/07/17 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/07/17 06:00
PHST- 2012/06/18 00:00 [received]
PHST- 2012/06/20 00:00 [accepted]
PHST- 2012/07/17 06:00 [entrez]
PHST- 2012/07/17 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - S0015-0282(12)00698-X [pii]
AID - 10.1016/j.fertnstert.2012.06.045 [doi]
PST - ppublish
SO  - Fertil Steril. 2012 Oct;98(4):804-7. doi: 10.1016/j.fertnstert.2012.06.045. Epub 
      2012 Jul 12.


PMID- 22795663
OWN - NLM
STAT- MEDLINE
DCOM- 20130124
LR  - 20120910
IS  - 1578-8989 (Electronic)
IS  - 0025-7753 (Linking)
VI  - 139
IP  - 8
DP  - 2012 Oct 6
TI  - [Descriptive analysis of clinical trials with pharmacogenetics substudy submitted
      to the Ethics Committee of Andalusia, Spain (2005-2008)].
PG  - 354-7
LID - 10.1016/j.medcli.2012.05.012 [doi]
FAU - Alanis Lopez, Joaquin
AU  - Alanis Lopez J
AD  - Servicio de Farmacia, Hospital Universitario Reina Sofia, Cordoba, Espana.
      jalanis_lopez@hotmail.com
FAU - Fernandez Lopez, Juan Antonio
AU  - Fernandez Lopez JA
FAU - Carretero Guerra, Rafael
AU  - Carretero Guerra R
FAU - Duran Quintana, Jose Antonio
AU  - Duran Quintana JA
LA  - spa
PT  - Journal Article
TT  - Analisis descriptivo de los ensayos clinicos con subestudio farmacogenetico
      presentados al Comite Autonomico de Andalucia (2005-2008).
DEP - 20120712
PL  - Spain
TA  - Med Clin (Barc)
JT  - Medicina clinica
JID - 0376377
SB  - IM
MH  - Clinical Trials as Topic/*methods/statistics & numerical data/trends
MH  - Ethics Committees, Research
MH  - Humans
MH  - Multicenter Studies as Topic/statistics & numerical data/trends
MH  - Pharmacogenetics/statistics & numerical data/*trends
MH  - Research Support as Topic/statistics & numerical data/trends
MH  - Retrospective Studies
MH  - Spain
EDAT- 2012/07/17 06:00
MHDA- 2013/01/25 06:00
CRDT- 2012/07/17 06:00
PHST- 2012/04/12 00:00 [received]
PHST- 2012/05/03 00:00 [accepted]
PHST- 2012/07/17 06:00 [entrez]
PHST- 2012/07/17 06:00 [pubmed]
PHST- 2013/01/25 06:00 [medline]
AID - S0025-7753(12)00519-2 [pii]
AID - 10.1016/j.medcli.2012.05.012 [doi]
PST - ppublish
SO  - Med Clin (Barc). 2012 Oct 6;139(8):354-7. doi: 10.1016/j.medcli.2012.05.012. Epub
      2012 Jul 12.


PMID- 22795429
OWN - NLM
STAT- MEDLINE
DCOM- 20130314
LR  - 20161125
IS  - 1532-8171 (Electronic)
IS  - 0735-6757 (Linking)
VI  - 31
IP  - 1
DP  - 2013 Jan
TI  - Prognostic values of blood ammonia and partial pressure of ammonia on hospital
      arrival in out-of-hospital cardiac arrests.
PG  - 8-15
LID - 10.1016/j.ajem.2012.04.037 [doi]
LID - S0735-6757(12)00202-1 [pii]
AB  - PURPOSES: Outcome prediction for out-of-hospital cardiac arrest (OHCA) is of
      medical, ethical, and socioeconomic importance. We hypothesized that blood
      ammonia may reflect tissue hypoxia in OHCA patients and conducted this study to
      evaluate the prognostic value of ammonia for the return of spontaneous
      circulation (ROSC). METHODS: This prospective, observational study was conducted 
      in a tertiary university hospital between January 2008 and December 2008. The
      subjects consisted of OHCA patients who were sent to the emergency department
      (ED). The primary outcome was ROSC. The prognostic values were calculated for
      ammonia levels and the partial pressure of ammonia (pNH(3)), and the results were
      depicted as a receiver operating characteristics curve with an area under the
      curve. RESULTS: Among 119 patients enrolled in this study, 28 patients (23.5%)
      achieved ROSC. Ammonia levels and pNH(3) in the non-ROSC group were significantly
      higher than those in the ROSC group (167.0 mumol/L vs 80.0 mumol/L, P < .05; 2.61
      x 10(-5) vs 1.67 x 10(-5) mm Hg, P < .05, respectively). The predictive capacity 
      of area under the curve for ammonia and pNH(3) for non-ROSC was 0.85 (95%
      confidence interval, 0.75-0.95) and 0.73 (95% confidence interval, 0.61-0.84),
      respectively. The multivariate analysis confirmed that ammonia and pNH(3) are
      independent predictors of non-ROSC. The prognostic value of ammonia was better
      than that of pNH(3). The cutoff level for ammonia of 84 mumol/L was 94.5%
      sensitive and 75.0% specific for predicting non-ROSC with a diagnostic accuracy
      of 89.9%. CONCLUSIONS: Hyperammonemia on ED arrival is independently predictive
      of non-ROSC for OHCA patients. The findings may offer useful information for
      clinical management.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Lin, Chih-Hao
AU  - Lin CH
AD  - Department of Emergency Medicine, National Cheng Kung University Hospital,
      College of Medicine, National Cheng Kung University, Tainan 70403, Taiwan.
      emergency.lin@gmail.com
FAU - Chi, Chih-Hsien
AU  - Chi CH
FAU - Wu, Shyu-Yu
AU  - Wu SY
FAU - Hsu, Hsiang-Chin
AU  - Hsu HC
FAU - Chang, Ying-Hsin
AU  - Chang YH
FAU - Huang, Yao-Yi
AU  - Huang YY
FAU - Chang, Chih-Jan
AU  - Chang CJ
FAU - Hong, Ming-Yuan
AU  - Hong MY
FAU - Chan, Tsung-Yu
AU  - Chan TY
FAU - Shih, Hsin-I
AU  - Shih HI
LA  - eng
PT  - Journal Article
DEP - 20120712
PL  - United States
TA  - Am J Emerg Med
JT  - The American journal of emergency medicine
JID - 8309942
RN  - 7664-41-7 (Ammonia)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Ammonia/*blood
MH  - Blood Gas Analysis
MH  - Cardiopulmonary Resuscitation
MH  - Chi-Square Distribution
MH  - Emergency Service, Hospital
MH  - Female
MH  - Humans
MH  - Hypoxia/blood
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Out-of-Hospital Cardiac Arrest/*blood/therapy
MH  - Partial Pressure
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Prospective Studies
MH  - ROC Curve
MH  - Sensitivity and Specificity
EDAT- 2012/07/17 06:00
MHDA- 2013/03/15 06:00
CRDT- 2012/07/17 06:00
PHST- 2012/03/04 00:00 [received]
PHST- 2012/04/04 00:00 [revised]
PHST- 2012/04/28 00:00 [accepted]
PHST- 2012/07/17 06:00 [entrez]
PHST- 2012/07/17 06:00 [pubmed]
PHST- 2013/03/15 06:00 [medline]
AID - S0735-6757(12)00202-1 [pii]
AID - 10.1016/j.ajem.2012.04.037 [doi]
PST - ppublish
SO  - Am J Emerg Med. 2013 Jan;31(1):8-15. doi: 10.1016/j.ajem.2012.04.037. Epub 2012
      Jul 12.


PMID- 22795317
OWN - NLM
STAT- MEDLINE
DCOM- 20140124
LR  - 20130419
IS  - 2210-741X (Electronic)
IS  - 2210-7401 (Linking)
VI  - 37
IP  - 2
DP  - 2013 Apr
TI  - Microsurgery and liver research: Lumbricus terrestris, a reliable animal model
      for training?
PG  - 166-70
LID - 10.1016/j.clinre.2012.04.008 [doi]
LID - S2210-7401(12)00127-1 [pii]
AB  - BACKGROUND: Experiments using animal models are the most common way to learn
      microsurgery. This expertise is necessary for liver research, microsurgical
      reconstruction of the esophagus by free jejunum or reconstruction of the hepatic 
      artery during reimplantation from living donors. The goal of this prospective
      study is to assess the reliability of an invertebrate model for microsurgical
      training. METHODS: Between November 2011 and January 2012, 150 microsurgical
      trainings simulating vascular end-to-end microanastomoses were performed on 134
      earthworms. The trainings were divided into 10 periods of 1 week each that
      included 15 simulations of end-to-end vascular microanastomoses: larger than
      1.5mm (n=5), ranging in size from 1.0 to 1.5mm (n=5), and size less than 1.0mm
      (n=5). The technique is presented and documented. RESULTS: For diameters greater 
      than 1.5mm, the mean anastomosis time decreased from 17.9 +/- 0.9 min to 9.9 +/- 
      0.2 min between the first and last week of training. For training with smaller
      diameters, the results showed a decrease in execution time of 41.8% (diameters
      between 1.0 and 1.5mm) and 38.6% (diameters<1.0mm) between the first and last
      periods. The study underlines an improvement in the dexterity and speed of nodes'
      execution. CONCLUSION: The earthworm appears to be a reliable experimental model 
      for microsurgical training. It is more ethical than using rats, less expensive
      than vertebrate animal models, and allows the operator to gain in both confidence
      and time of execution.
CI  - Copyright (c) 2012. Published by Elsevier Masson SAS.
FAU - Leclere, Franck Marie P
AU  - Leclere FM
AD  - Department of Plastic and Hand Surgery, University of Bern, Bern, Switzerland.
      franck.leclere@inserm.fr
FAU - Lewbart, Gregory A
AU  - Lewbart GA
FAU - Rieben, Robert
AU  - Rieben R
FAU - Vogelin, Esther
AU  - Vogelin E
LA  - eng
PT  - Journal Article
DEP - 20120712
PL  - France
TA  - Clin Res Hepatol Gastroenterol
JT  - Clinics and research in hepatology and gastroenterology
JID - 101553659
SB  - IM
MH  - Anastomosis, Surgical/*education
MH  - Animals
MH  - Learning Curve
MH  - Microsurgery/*education
MH  - *Models, Animal
MH  - *Oligochaeta
MH  - Prospective Studies
EDAT- 2012/07/17 06:00
MHDA- 2014/01/25 06:00
CRDT- 2012/07/17 06:00
PHST- 2012/03/17 00:00 [received]
PHST- 2012/04/17 00:00 [accepted]
PHST- 2012/07/17 06:00 [entrez]
PHST- 2012/07/17 06:00 [pubmed]
PHST- 2014/01/25 06:00 [medline]
AID - S2210-7401(12)00127-1 [pii]
AID - 10.1016/j.clinre.2012.04.008 [doi]
PST - ppublish
SO  - Clin Res Hepatol Gastroenterol. 2013 Apr;37(2):166-70. doi:
      10.1016/j.clinre.2012.04.008. Epub 2012 Jul 12.


PMID- 22795052
OWN - NLM
STAT- MEDLINE
DCOM- 20130314
LR  - 20121002
IS  - 1873-6513 (Electronic)
IS  - 0885-3924 (Linking)
VI  - 44
IP  - 4
DP  - 2012 Oct
TI  - Quality of care in palliative sedation: audit and compliance monitoring of a
      clinical protocol.
PG  - 532-41
LID - 10.1016/j.jpainsymman.2011.10.029 [doi]
LID - S0885-3924(12)00207-2 [pii]
AB  - CONTEXT: The European Association for Palliative Care and the U.S. National
      Hospice and Palliative Care Organization have published statements that recommend
      an audit of palliative sedation practices. OBJECTIVES: The aim was to assess the 
      feasibility of a quality care project in palliative sedation. METHODS: We carried
      out an audit of adherence to a guideline regarding palliative sedation,
      undertaken as a yearly assessment during two years, of a sample of patient
      charts. With an audit tool, the charts were evaluated as to the presence of the
      ethical sedation checklist, information that justified palliative sedation,
      patient and/or family agreement, and the appropriateness of treatment in
      concordance with the clinical protocol. An educational program and result
      feedback meetings were used as the implementation strategy. RESULTS: Roughly 25% 
      of the medical charts of patients who died in the palliative care unit were
      evaluated, 94 in 2007 and 110 in 2008. In 2007 and 2008, 63% and 57% of the
      patients, respectively, whose median age was 65 years, were sedated, with a
      median length of two days. The main reason for sedation was agitation concomitant
      with respiratory failure in roughly 60% and 75% of the cases in 2007 and 2008,
      respectively. Agreement of the patient/family about sedation was collected from
      100% of the cases. The concordance of procedures with the sedation guideline was 
      100% in both years. CONCLUSION: Our quality-of-care strategy was shown to obtain 
      a higher level of compliance with the palliative sedation guideline for at least 
      two years.
CI  - Copyright (c) 2012 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. 
      All rights reserved.
FAU - Benitez-Rosario, Miguel Angel
AU  - Benitez-Rosario MA
AD  - Palliative Care Unit, Nuestra Senora de Candelaria University Hospital, Tenerife,
      Spain. mabenros@gmail.com
FAU - Castillo-Padros, Manuel
AU  - Castillo-Padros M
FAU - Garrido-Bernet, Belen
AU  - Garrido-Bernet B
FAU - Ascanio-Leon, Belen
AU  - Ascanio-Leon B
LA  - eng
PT  - Journal Article
DEP - 20120712
PL  - United States
TA  - J Pain Symptom Manage
JT  - Journal of pain and symptom management
JID - 8605836
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Conscious Sedation/methods/*standards
MH  - Feasibility Studies
MH  - Female
MH  - Guideline Adherence/*standards
MH  - Hospice Care/standards
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Palliative Care/methods/*standards
MH  - Quality of Health Care/*standards
EDAT- 2012/07/17 06:00
MHDA- 2013/03/15 06:00
CRDT- 2012/07/17 06:00
PHST- 2011/07/01 00:00 [received]
PHST- 2011/10/25 00:00 [revised]
PHST- 2011/11/01 00:00 [accepted]
PHST- 2012/07/17 06:00 [entrez]
PHST- 2012/07/17 06:00 [pubmed]
PHST- 2013/03/15 06:00 [medline]
AID - S0885-3924(12)00207-2 [pii]
AID - 10.1016/j.jpainsymman.2011.10.029 [doi]
PST - ppublish
SO  - J Pain Symptom Manage. 2012 Oct;44(4):532-41. doi:
      10.1016/j.jpainsymman.2011.10.029. Epub 2012 Jul 12.


PMID- 22794161
OWN - NLM
STAT- MEDLINE
DCOM- 20130618
LR  - 20191112
IS  - 2212-3938 (Electronic)
IS  - 1574-8847 (Linking)
VI  - 7
IP  - 4
DP  - 2012 Nov
TI  - Development steps of pharmacokinetics: a perspective on bioanalytical methods and
      bioequivalence.
PG  - 328-32
AB  - This paper describes the main development steps of pharmacokinetics that
      paralleled the development of analytical bioassay methods. From the first
      stirrings on 1950s, with very sensitive but not specific radiotracing
      measurements using 14C or 3H labelled drugs, to further developments with more
      specific methods like gas chromatography, high pressure liquid chromatography, to
      the last achievement with tandem mass spectrometry, pharmacokinetics has
      supported all the development procedures of both NDA (New Drug Application) and
      ANDA (Abridged New Drug Application). The discovery of new therapeutic active
      molecules is now concentrated in a few very big companies, and requires
      pharmacokinetic support from the first screening procedures to the last clinical 
      developments. Medium and small pharmaceutical companies largely use
      pharmacokinetics for various new applications of existing drugs now out of
      patent, that require only or mainly pharmacokinetic, bioavailability,
      bioequivalence investigations in compliance with the ANDA procedure. In spite of 
      guidelines published by US FDA and EU EMA, some open problems on bioequivalence
      would still require more attention from regulatory authorities, like how to
      manage the puzzle of endogenous substances, ethical problems against the
      repeated-dose regimen with some drugs and how to manage Cmax in the presence of
      the multiple-peak phenomenon.
FAU - Marzo, Antonio
AU  - Marzo A
AD  - Clinical Pharmacology Unit, Institute for Pharmacokinetic and Analytical Studies 
      SA, Via Mastri 36, 6853 Ligornetto Switzerland. antonio.marzo@ipas-research.com
LA  - eng
PT  - Journal Article
PL  - United Arab Emirates
TA  - Curr Clin Pharmacol
JT  - Current clinical pharmacology
JID - 101273158
SB  - IM
MH  - Biological Assay
MH  - Humans
MH  - Models, Biological
MH  - Tandem Mass Spectrometry
MH  - *Therapeutic Equivalency
EDAT- 2012/07/17 06:00
MHDA- 2013/06/19 06:00
CRDT- 2012/07/17 06:00
PHST- 2012/02/03 00:00 [received]
PHST- 2012/03/17 00:00 [revised]
PHST- 2012/05/28 00:00 [accepted]
PHST- 2012/07/17 06:00 [entrez]
PHST- 2012/07/17 06:00 [pubmed]
PHST- 2013/06/19 06:00 [medline]
AID - CCP-EPUB-20120709-8 [pii]
AID - 10.2174/157488412803305867 [doi]
PST - ppublish
SO  - Curr Clin Pharmacol. 2012 Nov;7(4):328-32. doi: 10.2174/157488412803305867.


PMID- 22793974
OWN - NLM
STAT- MEDLINE
DCOM- 20150713
LR  - 20120716
IS  - 1806-907X (Electronic)
IS  - 0034-7094 (Linking)
VI  - 62
IP  - 4
DP  - 2012 Jul
TI  - Palliative sedation of terminally ill patients.
PG  - 580-92
LID - 10.1016/S0034-7094(12)70157-5 [doi]
AB  - BACKGROUND AND OBJECTIVES: Although there is extensive discussion on the subject 
      in medical literature, most of the questions still unanswered due to the lack of 
      clear definitions and guidelines, in addition to a large number of contradictions
      in literature. The aim of this review is to try to determine the best form of
      sedation for patients with cancer. CONTENT: The following data on sedation were
      collected: definitions, classifications, major events and indication criteria,
      selection of drugs used, drugs most used, doses and routes, duration of sedation,
      nutritional support and hydration during sedation, and sedation at home.
      CONCLUSIONS: Although in recent years palliative sedation is being considered a
      normal medical practice, there are still many gaps in our current understanding. 
      There is no consensus about which are the standard drugs, maintenance or not of
      food, fluid intake, and hydration. Moreover, there is no ethical clarification on
      possible life-shortening effects and decision-making process.
CI  - Copyright (c) 2012 Elsevier Editora Ltda. All rights reserved.
FAU - Nogueira, Fabiola Leite
AU  - Nogueira FL
AD  - Department of Anesthesiology, Pain and Intensive Care, Universidade Federal de
      Sao Paulo, SP, Brazil.
FAU - Sakata, Rioko Kimiko
AU  - Sakata RK
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Brazil
TA  - Rev Bras Anestesiol
JT  - Revista brasileira de anestesiologia
JID - 0401316
SB  - IM
MH  - *Deep Sedation
MH  - Humans
MH  - Palliative Care/*methods
MH  - *Terminally Ill
EDAT- 2012/07/17 06:00
MHDA- 2015/07/15 06:00
CRDT- 2012/07/17 06:00
PHST- 2011/02/08 00:00 [received]
PHST- 2011/09/05 00:00 [accepted]
PHST- 2012/07/17 06:00 [entrez]
PHST- 2012/07/17 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
AID - S0034-7094(12)70157-5 [pii]
AID - 10.1016/S0034-7094(12)70157-5 [doi]
PST - ppublish
SO  - Rev Bras Anestesiol. 2012 Jul;62(4):580-92. doi: 10.1016/S0034-7094(12)70157-5.


PMID- 22793046
OWN - NLM
STAT- MEDLINE
DCOM- 20121120
LR  - 20181201
IS  - 1555-3892 (Electronic)
IS  - 0963-6897 (Linking)
VI  - 21
IP  - 2-3
DP  - 2012
TI  - Regenerative cells for transplantation in hepatic failure.
PG  - 387-99
LID - 10.3727/096368911X605286 [doi]
AB  - Human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells have an 
      enormous potential; however, their potential clinical application is being
      arrested due to various limitations such as teratoma formation followed by
      tumorigenesis, emergent usage, and the quality control of cells, as well as
      safety issues regarding long-term culture are also delaying their clinical
      application. In addition, human ES cells have two crucial issues: immunogenicity 
      and ethical issues associated with their clinical application. The efficient
      generation of human iPS cells requires gene transfer, yet the mechanism
      underlying pluripotent stem cell induction has not yet been fully elucidated.
      Otherwise, although human adult regenerative cells including mesenchymal stem
      cells have a limited capacity for differentiation, they are nevertheless
      promising candidates for tissue regeneration in a clinical setting. This review
      highlights the use of regenerative cells for transplantation in hepatic failure.
FAU - Ishikawa, Tetsuya
AU  - Ishikawa T
AD  - Division of Molecular and Cellular Medicine, National Cancer Center Research
      Institute, Chuo-ku, Tokyo, Japan.
FAU - Banas, Agnieszka
AU  - Banas A
FAU - Teratani, Takumi
AU  - Teratani T
FAU - Iwaguro, Hideki
AU  - Iwaguro H
FAU - Ochiya, Takahiro
AU  - Ochiya T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Cell Transplant
JT  - Cell transplantation
JID - 9208854
SB  - IM
MH  - Adipose Tissue/cytology
MH  - Bone Marrow Cells/cytology
MH  - Cell Differentiation
MH  - Embryonic Stem Cells/*cytology/immunology/transplantation
MH  - Humans
MH  - Induced Pluripotent Stem Cells/cytology/transplantation
MH  - Liver Failure/*therapy
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Mesenchymal Stem Cells/cytology/metabolism
MH  - *Regenerative Medicine
MH  - Tissue Engineering
EDAT- 2012/07/17 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/17 06:00
PHST- 2012/07/17 06:00 [entrez]
PHST- 2012/07/17 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.3727/096368911X605286 [doi]
PST - ppublish
SO  - Cell Transplant. 2012;21(2-3):387-99. doi: 10.3727/096368911X605286.


PMID- 22792650
OWN - NLM
STAT- MEDLINE
DCOM- 20120814
LR  - 20120716
IS  - 0043-3284 (Print)
IS  - 0043-3284 (Linking)
VI  - 108
IP  - 3
DP  - 2012 May-Jun
TI  - A tale of two patients--leadership in the art, science and ethics of prevention.
PG  - 10-3
FAU - Felsen, James D
AU  - Felsen JD
LA  - eng
PT  - Journal Article
PL  - United States
TA  - W V Med J
JT  - The West Virginia medical journal
JID - 0413777
SB  - IM
MH  - Humans
MH  - *Physician's Role
MH  - *Primary Health Care
MH  - Primary Prevention/*ethics
MH  - Secondary Prevention/ethics
MH  - United States
EDAT- 2012/07/17 06:00
MHDA- 2012/08/15 06:00
CRDT- 2012/07/17 06:00
PHST- 2012/07/17 06:00 [entrez]
PHST- 2012/07/17 06:00 [pubmed]
PHST- 2012/08/15 06:00 [medline]
PST - ppublish
SO  - W V Med J. 2012 May-Jun;108(3):10-3.


PMID- 22792648
OWN - NLM
STAT- MEDLINE
DCOM- 20120814
LR  - 20120716
IS  - 0043-3284 (Print)
IS  - 0043-3284 (Linking)
VI  - 108
IP  - 3
DP  - 2012 May-Jun
TI  - Ethics and rationing of healthcare.
PG  - 6
FAU - Cater, MaryAnn Nicholas
AU  - Cater MN
LA  - eng
PT  - Journal Article
PL  - United States
TA  - W V Med J
JT  - The West Virginia medical journal
JID - 0413777
SB  - IM
MH  - Age Factors
MH  - Decision Making/ethics
MH  - Health Care Rationing/*ethics
MH  - Humans
MH  - United States
EDAT- 2012/07/17 06:00
MHDA- 2012/08/15 06:00
CRDT- 2012/07/17 06:00
PHST- 2012/07/17 06:00 [entrez]
PHST- 2012/07/17 06:00 [pubmed]
PHST- 2012/08/15 06:00 [medline]
PST - ppublish
SO  - W V Med J. 2012 May-Jun;108(3):6.


PMID- 30890881
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1179-9900 (Electronic)
IS  - 1179-9900 (Linking)
VI  - 2
DP  - 2012
TI  - Stem cells and regenerative therapies for Parkinson's disease.
PG  - 79-92
LID - 10.2147/DNND.S16087 [doi]
AB  - Currently the mainstay of Parkinson's disease (PD) therapy is the pharmacological
      replacement of the loss of the dopaminergic nigrostriatal pathway using drugs
      such as dopamine agonists and levodopa. Whilst these drugs effectively ameliorate
      some of the motor features of PD, they do not improve many of the nonmotor
      features that arise secondary to pathology outside of this system, nor do they
      slow the progressive neurodegeneration that is a characteristic of the disease.
      Regenerative therapies for PD seek to fill this therapeutic gap, with cell
      transplantation being the most explored approach to date. A number of different
      cell sources have been used in this therapeutic approach, but to date, the most
      successful has been the use of fetal ventral mesencephalic (VM) tissue that
      contains within it the developing nigral dopaminergic cells. Cell transplantation
      for PD was pioneered in the 1980-1990s, with several successful open-label trials
      of fetal VM transplantation in patients with relatively advanced PD. Whilst these
      findings were not replicated in two subsequent double-blind sham-surgery
      controlled trials, there were reasons to explain this outside of the one drawn at
      the time that these therapies are ineffective. Indeed all these studies have
      provided evidence that following the transplantation of fetal VM tissue,
      dopaminergic cells can survive long term, produce dopamine, and bring about
      clinical improvements in younger patients over many years. The use of fetal
      tissue, irrespective of its true efficacy, will never become a widely available
      therapy for PD for a host of practical and ethical reasons, and thus much work
      has been put in recently to exploring the utility of stem cells as a source of
      nigral dopaminergic neurons. In this respect, the advent of embryonic stem cell
      and induced pluripotent cells has heralded a new era in cell therapy for PD, and 
      several groups have now demonstrated that these cells can form dopaminergic
      neurons which improve functional deficits in animal models of PD. Whilst
      encouraging, problems with respect to the immunogenicity and tumorigenicity of
      these cells means that they will need to be used in the clinic cautiously. Other 
      regenerative therapies in PD have been tried over the years and include the use
      of trophic factors. This has primarily involved glial cell line-derived
      neurotrophic factor (GDNF) and again has produced mixed clinical effects, and in 
      order to try and resolve this, a new trial of intraputamenal GDNF is now being
      planned. In addition, a new trial for platelet derived growth factor as a
      treatment for PD has just completed recruitment, and PYM50028 (Cogane) an oral
      agent shown in animal models to reduce the effects of MPTP
      (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) lesioning by the induction of
      growth factors is currently under investigation in a multicentre Phase II trial. 
      Overall, there are a number of promising new regenerative therapies being
      developed and tested in PD, although the true long-term efficacy of any of these 
      in large numbers of patients is still not known.
FAU - Farrell, Krista
AU  - Farrell K
AD  - Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, UK,
      rab46@cam.ac.uk.
FAU - Barker, Roger A
AU  - Barker RA
AD  - Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, UK,
      rab46@cam.ac.uk.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120715
PL  - New Zealand
TA  - Degener Neurol Neuromuscul Dis
JT  - Degenerative neurological and neuromuscular disease
JID - 101587980
PMC - PMC6065567
OTO - NOTNLM
OT  - cell therapy
OT  - transplantation
COIS- Disclosure The authors report no conflicts of interest in this work.
EDAT- 2012/07/15 00:00
MHDA- 2012/07/15 00:01
CRDT- 2019/03/21 06:00
PHST- 2019/03/21 06:00 [entrez]
PHST- 2012/07/15 00:00 [pubmed]
PHST- 2012/07/15 00:01 [medline]
AID - 10.2147/DNND.S16087 [doi]
AID - dnnd-2-079 [pii]
PST - epublish
SO  - Degener Neurol Neuromuscul Dis. 2012 Jul 15;2:79-92. doi: 10.2147/DNND.S16087.
      eCollection 2012.


PMID- 22792319
OWN - NLM
STAT- MEDLINE
DCOM- 20130402
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 7
DP  - 2012
TI  - Participant informed consent in cluster randomized trials: review.
PG  - e40436
LID - 10.1371/journal.pone.0040436 [doi]
AB  - BACKGROUND: The Nuremberg code defines the general ethical framework of medical
      research with participant consent as its cornerstone. In cluster randomized
      trials (CRT), obtaining participant informed consent raises logistic and
      methodologic concerns. First, with randomization of large clusters such as
      geographical areas, obtaining individual informed consent may be impossible.
      Second, participants in randomized clusters cannot avoid certain interventions,
      which implies that participant informed consent refers only to data collection,
      not administration of an intervention. Third, complete participant information
      may be a source of selection bias, which then raises methodological concerns. We 
      assessed whether participant informed consent was required in such trials, which 
      type of consent was required, and whether the trial was at risk of selection bias
      because of the very nature of participant information. METHODS AND FINDINGS: We
      systematically reviewed all reports of CRT published in MEDLINE in 2008 and
      surveyed corresponding authors regarding the nature of the informed consent and
      the process of participant inclusion. We identified 173 reports and obtained an
      answer from 113 authors (65.3%). In total, 23.7% of the reports lacked
      information on ethics committee approval or participant consent, 53.1% of authors
      declared that participant consent was for data collection only and 58.5% that the
      group allocation was not specified for participants. The process of recruitment
      (chronology of participant recruitment with regard to cluster randomization) was 
      rarely reported, and we estimated that only 56.6% of the trials were free of
      potential selection bias. CONCLUSIONS: For CRTs, the reporting of ethics
      committee approval and participant informed consent is less than optimal. Reports
      should describe whether participants consented for administration of an
      intervention and/or data collection. Finally, the process of participant
      recruitment should be fully described (namely, whether participants were informed
      of the allocation group before being recruited) for a better appraisal of the
      risk of selection bias.
FAU - Giraudeau, Bruno
AU  - Giraudeau B
AD  - INSERM, U738, Paris, France. giraudeau@med.univ-tours.fr
FAU - Caille, Agnes
AU  - Caille A
FAU - Le Gouge, Amelie
AU  - Le Gouge A
FAU - Ravaud, Philippe
AU  - Ravaud P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120706
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Ethics Committees, Research
MH  - Humans
MH  - *Informed Consent
MH  - Patient Selection
MH  - Practice Guidelines as Topic
MH  - Randomized Controlled Trials as Topic/*standards
MH  - Selection Bias
MH  - Surveys and Questionnaires
PMC - PMC3391275
EDAT- 2012/07/14 06:00
MHDA- 2013/04/03 06:00
CRDT- 2012/07/14 06:00
PHST- 2012/01/24 00:00 [received]
PHST- 2012/06/07 00:00 [accepted]
PHST- 2012/07/14 06:00 [entrez]
PHST- 2012/07/14 06:00 [pubmed]
PHST- 2013/04/03 06:00 [medline]
AID - 10.1371/journal.pone.0040436 [doi]
AID - PONE-D-12-02854 [pii]
PST - ppublish
SO  - PLoS One. 2012;7(7):e40436. doi: 10.1371/journal.pone.0040436. Epub 2012 Jul 6.


PMID- 22791999
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1178-7090 (Electronic)
IS  - 1178-7090 (Linking)
VI  - 5
DP  - 2012
TI  - Pattern of postoperative pain management among adult surgical patients in a
      low-resource setting.
PG  - 117-20
LID - 10.2147/JPR.S28198 [doi]
AB  - OBJECTIVE: Postoperative pain is one of the most common complications of surgery.
      The pattern of management varies between centers. The current study aimed to
      study the prescription pattern and the common drugs used in the management of
      postoperative pain in adult surgical patients at Ahmadu Bello University Teaching
      Hospital (ABUTH; Zaria, Nigeria). METHODS: Following ethical approval, a
      prospective observational study of consecutive adult patients who had surgery at 
      the ABUTH Zaria was performed from January to December 2005. The data were
      entered into a proforma and analyzed using the Minitab statistical package.
      RESULTS: One hundred and thirty-eight patients were included in the study. The
      age range was 17 to 80 years, with a mean age of 41 years. One hundred and
      thirty-two (95.7%) of the prescriptions were written solely by the surgeon or
      surgical resident; passive suggestions were given by the anesthetists for only
      six patients (4.3%). Intermittent intramuscular injections of opioids/opiates
      were prescribed for 126 patients (91.3%), while nine patients (6.5%) received
      intermittent intramuscular injections with non-steroidal anti-inflammatory drugs.
      Oral paracetamol was prescribed for six patients (4.3%), while three patients
      (2.1%) received no postoperative analgesic. Moderate pain was recorded in 48
      patients (34.8%), and 90 patients (65.2%) had mild pain 8 hours after their
      operation before subsequent doses of analgesics were given. More females (81
      patients [58.7%]), than males (42 patients [29.7%]) suffered moderate to severe
      pain. The reported side effects were nausea (reported by 32.6% of patients), dry 
      mouth (21.7%), vomiting (13.0%), and urinary retention (6.5%), with 32.6% of
      patients experiencing no side effects. The three patients who received no
      analgesics experienced vomiting as a side effect. Despite the high incidence of
      pain and other side effects, 108 patients (78.2%) still reported that the methods
      of postoperative pain management were satisfactory. CONCLUSION: Despite recent
      advances and the development of more effective techniques for postoperative pain 
      control, a high proportion of patients still experience moderate to severe
      postoperative pain. Intermittent intramuscular injection of analgesic medication 
      remains the mainstay of postoperative pain management at the ABUTH Zaria.
      Anesthetists should be more involved in postoperative analgesia prescriptions and
      should include other forms of multimodal pain management in their regimens. With 
      proper application of current knowledge and training, postoperative pain
      management can be improved.
FAU - Ogboli-Nwasor, Elizabeth
AU  - Ogboli-Nwasor E
AD  - Department of Anaesthesia, Ahmadu Bello University Teaching Hospital, Zaria,
      Nigeria.
FAU - Sule, Sa'adatu T
AU  - Sule ST
FAU - Yusufu, Lazarus Md
AU  - Yusufu LM
LA  - eng
PT  - Journal Article
DEP - 20120601
PL  - New Zealand
TA  - J Pain Res
JT  - Journal of pain research
JID - 101540514
PMC - PMC3392713
OTO - NOTNLM
OT  - adult surgery
OT  - pain management
OT  - postoperative
EDAT- 2012/07/14 06:00
MHDA- 2012/07/14 06:01
CRDT- 2012/07/14 06:00
PHST- 2012/07/14 06:00 [entrez]
PHST- 2012/07/14 06:00 [pubmed]
PHST- 2012/07/14 06:01 [medline]
AID - 10.2147/JPR.S28198 [doi]
AID - jpr-5-117 [pii]
PST - ppublish
SO  - J Pain Res. 2012;5:117-20. doi: 10.2147/JPR.S28198. Epub 2012 Jun 1.


PMID- 22791212
OWN - NLM
STAT- MEDLINE
DCOM- 20130514
LR  - 20220408
IS  - 1530-0366 (Electronic)
IS  - 1098-3600 (Linking)
VI  - 14
IP  - 12
DP  - 2012 Dec
TI  - Variability in laboratory reporting practices for regions of homozygosity
      indicating parental relatedness as identified by SNP microarray testing.
PG  - 971-6
LID - 10.1038/gim.2012.83 [doi]
AB  - PURPOSE: Single-nucleotide polymorphism (SNP) microarrays are capable of
      detecting regions of homozygosity (ROH) that can suggest parental consanguinity
      or incest. This study was designed to describe the variable reporting practices
      of clinical laboratories in the United States regarding ROH found on SNP
      microarray tests, to discuss the follow-up practices of laboratory personnel when
      findings of ROH indicate consanguinity or incest, and to highlight the legal and 
      ethical dilemmas faced by workers who have discovered these incidental findings. 
      METHODS: A 20-question survey was administered to microarray experts at 18
      laboratories offering clinical SNP microarray tests. The results are presented
      using descriptive statistics. RESULTS: There was variability in laboratory SNP
      microarray reporting practices with respect to information and interpretation of 
      ROH findings. All the laboratories agreed that they have a duty to inform the
      ordering physician about results suggesting consanguinity or incest, but the
      follow-through practices varied among laboratories. CONCLUSIONS: This study
      discovered variability in reporting practices and follow-up procedures for
      microarray results that suggest parental consanguinity or incest. Our findings
      highlight the need for laboratory guidelines to standardize reporting practices
      for SNP microarray and other tests that are capable of detecting ROH.
FAU - Grote, Lauren
AU  - Grote L
AD  - Division of Human Genetics, Department of Pediatrics at Cincinnati Children's
      Hospital Medical Center, Cincinnati, Ohio, USA.
FAU - Myers, Melanie
AU  - Myers M
FAU - Lovell, Anne
AU  - Lovell A
FAU - Saal, Howard
AU  - Saal H
FAU - Lipscomb Sund, Kristen
AU  - Lipscomb Sund K
LA  - eng
PT  - Journal Article
DEP - 20120712
PL  - United States
TA  - Genet Med
JT  - Genetics in medicine : official journal of the American College of Medical
      Genetics
JID - 9815831
SB  - IM
MH  - Consanguinity
MH  - Disclosure
MH  - Genetic Testing/standards/*statistics & numerical data
MH  - *Homozygote
MH  - Humans
MH  - Incest/statistics & numerical data
MH  - Laboratory Personnel
MH  - Observer Variation
MH  - Oligonucleotide Array Sequence Analysis
MH  - *Polymorphism, Single Nucleotide
MH  - Surveys and Questionnaires
MH  - United States
EDAT- 2012/07/14 06:00
MHDA- 2013/05/15 06:00
CRDT- 2012/07/14 06:00
PHST- 2012/07/14 06:00 [entrez]
PHST- 2012/07/14 06:00 [pubmed]
PHST- 2013/05/15 06:00 [medline]
AID - S1098-3600(21)04564-0 [pii]
AID - 10.1038/gim.2012.83 [doi]
PST - ppublish
SO  - Genet Med. 2012 Dec;14(12):971-6. doi: 10.1038/gim.2012.83. Epub 2012 Jul 12.


PMID- 22790897
OWN - NLM
STAT- MEDLINE
DCOM- 20130724
LR  - 20191112
IS  - 2185-4610 (Electronic)
IS  - 0016-2590 (Linking)
VI  - 58
IP  - 1
DP  - 2012
TI  - Pitfalls and practicalities in collecting and banking human brain tissues for
      research on psychiatric and neulogical disorders.
PG  - 82-7
AB  - It is essential to examine brain materials for the understanding the cause and
      pathology of mental disorders. Recent methodological progress urges us to set up 
      well qualified brain banks. Human tissue and Bio-banking is a complex field and
      the daily practice of brain banks needs to abide by several golden standards in
      order to avoid pitfalls in basic research: 1) A donor system in which informed
      consent is granted for the use of the samples for scientific research, including 
      genetic analysis and access to medical records, 2) Rapid autopsy system, 3)
      Compatibility of protocols for procurement, management, handling and storage, 4) 
      A generally accepted consensus on diagnostic criteria, 5) Quality control, 6)
      Abiding by local/international legal and ethical guidelines for work with human
      material, 7) Proper safety procedures. In the present review, the authors
      introduced the activities of European brain banks, and discussed on their current
      issues, and on the problems remain to be resolved.
FAU - Ravid, Rivka
AU  - Ravid R
AD  - Netherlands Institute of Neurosciences, Meibergdreef 47, Amsterdam, The
      Netherlands.
FAU - Ikemoto, Keiko
AU  - Ikemoto K
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Fukushima J Med Sci
JT  - Fukushima journal of medical science
JID - 0374626
SB  - IM
MH  - Autopsy/ethics
MH  - *Brain
MH  - Humans
MH  - Informed Consent/ethics
MH  - Nervous System Diseases/pathology
MH  - Quality Control
MH  - Specimen Handling/*methods
MH  - Tissue Banks/*ethics/*legislation & jurisprudence
MH  - Tissue Donors/ethics
EDAT- 2012/07/14 06:00
MHDA- 2013/07/25 06:00
CRDT- 2012/07/14 06:00
PHST- 2012/07/14 06:00 [entrez]
PHST- 2012/07/14 06:00 [pubmed]
PHST- 2013/07/25 06:00 [medline]
AID - DN/JST.JSTAGE/fms/58.82 [pii]
AID - 10.5387/fms.58.82 [doi]
PST - ppublish
SO  - Fukushima J Med Sci. 2012;58(1):82-7. doi: 10.5387/fms.58.82.


PMID- 22790753
OWN - NLM
STAT- MEDLINE
DCOM- 20121213
LR  - 20120713
IS  - 1476-5373 (Electronic)
IS  - 0007-0610 (Linking)
VI  - 213
IP  - 1
DP  - 2012 Jul 13
TI  - The ethics of dental practice in London in the sixteenth century. 1. Henry
      Chettle's Kind-Harts dreame of 1592. An important lay view.
PG  - 27-30
LID - 10.1038/sj.bdj.2012.557 [doi]
AB  - Kind-Harts dreame (Fig. 1) is one of the proto-novels which first appeared in the
      Elizabethan age of literary wonders. It recounts the dream of the hero - a
      tooth-drawer (Kind-Hart) - who encounters the shades of five recently deceased
      characters, each of whom had been a famous star of their day in the London scene.
      Although short, and with medicine and dentistry occupying only part of the tale, 
      the story contains invaluable detailed information about dental care in late
      Tudor England as observed by a layman. It is also an amusing read.
FAU - Bishop, M
AU  - Bishop M
AD  - Bulls Mill House, Hertford, SG14 3NS.
LA  - eng
PT  - Biography
PT  - Historical Article
PT  - Journal Article
DEP - 20120713
PL  - England
TA  - Br Dent J
JT  - British dental journal
JID - 7513219
SB  - IM
MH  - Dental Care/*ethics/history
MH  - Famous Persons
MH  - *History of Dentistry
MH  - History, 16th Century
MH  - Humans
MH  - Literature, Modern/*history
MH  - London
MH  - Rare Books/history
PS  - Chettle H
FPS - Chettle, Henry
PS  - Kranich B
FPS - Kranich, Burchard
EDAT- 2012/07/14 06:00
MHDA- 2012/12/14 06:00
CRDT- 2012/07/14 06:00
PHST- 2012/04/19 00:00 [accepted]
PHST- 2012/07/14 06:00 [entrez]
PHST- 2012/07/14 06:00 [pubmed]
PHST- 2012/12/14 06:00 [medline]
AID - sj.bdj.2012.557 [pii]
AID - 10.1038/sj.bdj.2012.557 [doi]
PST - epublish
SO  - Br Dent J. 2012 Jul 13;213(1):27-30. doi: 10.1038/sj.bdj.2012.557.


PMID- 22790353
OWN - NLM
STAT- MEDLINE
DCOM- 20121029
LR  - 20161020
IS  - 1941-2479 (Electronic)
IS  - 1010-5395 (Linking)
VI  - 24
IP  - 4
DP  - 2012 Jul
TI  - Ethical issues in infant feeding after disasters.
PG  - 672-80
LID - 10.1177/1010539512453253 [doi]
AB  - In the aftermath of many disasters the silence is punctuated by the crying of
      infants, hungry infants. The aim of this paper is to discuss ethical issues in
      feeding infants after disasters. The Asia Pacific region generates 25% of the
      world's GDP, but experiences 45% of natural disasters and 42% of the economic
      losses due to disasters. The region has 61% of the world's population, but 86% of
      the population affected by disasters. Breastfeeding, exclusive to six months and 
      continuing thereafter, is important for growth and the health of the infant in
      the short term and later in life. In most natural disasters, mothers and infants 
      will both suffer, but in some disasters, such as earthquakes and building
      collapses, infants can survive in small spaces. Infants separated from mothers
      require a wet nurse (rarely available) or feeding with infant formula and sterile
      water. Formula companies often donate supplies of infant formula but distribution
      should follow ethical principles. Mothers who are injured or short of food can
      still continue breastfeeding and don't need formula. Where formula must be used, 
      health workers need to follow the highest ethical standards to avoid promoting
      infant formula to vulnerable communities in the post recovery phase.
FAU - Binns, Colin W
AU  - Binns CW
AD  - Curtin University, Perth, Australia. c.binns@curtin.edu.au
FAU - Lee, Mi Kyung
AU  - Lee MK
FAU - Tang, Li
AU  - Tang L
FAU - Yu, Chuan
AU  - Yu C
FAU - Hokama, Tomiko
AU  - Hokama T
FAU - Lee, Andy
AU  - Lee A
LA  - eng
PT  - Journal Article
DEP - 20120711
PL  - China
TA  - Asia Pac J Public Health
JT  - Asia-Pacific journal of public health
JID - 8708538
SB  - IM
MH  - *Breast Feeding
MH  - China
MH  - Disasters
MH  - Earthquakes
MH  - Humans
MH  - Indonesia
MH  - Infant
MH  - Infant Formula/*ethics
MH  - *Infant Nutritional Physiological Phenomena
MH  - Japan
MH  - Relief Work/*ethics
MH  - Tsunamis
EDAT- 2012/07/14 06:00
MHDA- 2012/10/30 06:00
CRDT- 2012/07/14 06:00
PHST- 2012/07/14 06:00 [entrez]
PHST- 2012/07/14 06:00 [pubmed]
PHST- 2012/10/30 06:00 [medline]
AID - 1010539512453253 [pii]
AID - 10.1177/1010539512453253 [doi]
PST - ppublish
SO  - Asia Pac J Public Health. 2012 Jul;24(4):672-80. doi: 10.1177/1010539512453253.
      Epub 2012 Jul 11.


PMID- 22789583
OWN - NLM
STAT- MEDLINE
DCOM- 20121127
LR  - 20120713
IS  - 1878-1926 (Electronic)
IS  - 0065-3101 (Linking)
VI  - 59
IP  - 1
DP  - 2012
TI  - Surgical and ethical challenges in disorders of sexual development.
PG  - 283-302
LID - 10.1016/j.yapd.2012.04.003 [doi]
AB  - A resolution to the difficulties faced by parents, physicians, and pediatric
      patients in treating DSDs will only come with better communication and improved
      research methodologies. Advocacy groups and the Internet have allowed the
      intersex community to have a larger role in guiding the research and the ethical 
      frameworks that are used in treating these disorders. These disorders are unusual
      and collaboration across medical centers should be the rule rather than the
      exception. When possible, treatments that are innovative or experimental should
      be subjected to rigorous research oversight [29,30]. Defined periods of family
      crisis in which counseling and education become important are at the time of
      diagnosis [30,31], at the time of any surgical procedure, and at the beginning of
      major developmental stages. Historically, children were often left uninformed
      until someone judged them old and mature enough to comprehend how they were
      different. These attempts to protect individual children from their condition may
      have left them vulnerable to a personal crisis at an age when sexual identity and
      identity with a peer group are important. Both the needs of the child and the
      adult the child will become should be considered in making treatment decisions
      for children and adolescents with DSDs. It is best to counsel parents and educate
      developing children in a way that parallels chronologic and conceptual growth.
      When possible, the child should be involved in an age-appropriate fashion in the 
      decision-making process and accurate information about the child's history and
      body should be made available. In addition, parents and families need as much
      information as possible and support systems that will help them navigate these
      challenging situations.
FAU - Fallat, Mary E
AU  - Fallat ME
AD  - Division of Pediatric Surgery, Department of Surgery, University of Louisville,
      KY 40202, USA. mefall01@louisville.edu
FAU - Hertweck, Paige
AU  - Hertweck P
FAU - Ralston, Steven J
AU  - Ralston SJ
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Adv Pediatr
JT  - Advances in pediatrics
JID - 0370436
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Decision Making/ethics
MH  - Disorders of Sex Development/diagnosis/physiopathology/*surgery
MH  - *Ethics, Clinical
MH  - *Gender Identity
MH  - Humans
MH  - Parents/education/psychology
MH  - Pediatrics/ethics
EDAT- 2012/07/14 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/14 06:00
PHST- 2012/07/14 06:00 [entrez]
PHST- 2012/07/14 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - S0065-3101(12)00004-7 [pii]
AID - 10.1016/j.yapd.2012.04.003 [doi]
PST - ppublish
SO  - Adv Pediatr. 2012;59(1):283-302. doi: 10.1016/j.yapd.2012.04.003.


PMID- 22789493
OWN - NLM
STAT- MEDLINE
DCOM- 20130117
LR  - 20131121
IS  - 1879-0720 (Electronic)
IS  - 0928-0987 (Linking)
VI  - 47
IP  - 2
DP  - 2012 Sep 29
TI  - Fast mouse PK (Fast PK): a rapid screening method to increase pharmacokinetic
      throughput in pre-clinical drug discovery.
PG  - 444-50
LID - 10.1016/j.ejps.2012.07.001 [doi]
AB  - We describe a rapid screening methodology for performing pharmacokinetic (PK)
      studies in mice called Fast PK. In this Fast PK method, two mice were used per
      compound and four blood samples were collected from each mouse. The sampling
      times were staggered (sparse sampling) between the two mice, thus yielding
      complete PK profile in singlicate across eight time points. The plasma PK
      parameters from Fast PK were comparable to that obtained from conventional PK
      methods. This method has been used to rapidly screen compounds in the early
      stages of drug discovery and about 600 compounds have been profiled in the last 3
      years, which has resulted in reduction in the usage of mice by 800 per year in
      compliance with the 3R principles of animal ethics. In addition, this Fast PK
      method can also help in evaluating the PK parameters from the same set of animals
      used in safety/toxicology/efficacy studies without the need for satellite groups.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Reddy, Jitendar
AU  - Reddy J
AD  - DMPK, Infection Innovative Medicines, AstraZeneca India Pvt. Ltd., Kirloskar
      Business Park, Hebbal, Bangalore 560 024, India.
FAU - Madishetti, Sreedhar
AU  - Madishetti S
FAU - Vachaspati, Prakash R
AU  - Vachaspati PR
LA  - eng
PT  - Journal Article
DEP - 20120709
PL  - Netherlands
TA  - Eur J Pharm Sci
JT  - European journal of pharmaceutical sciences : official journal of the European
      Federation for Pharmaceutical Sciences
JID - 9317982
RN  - 0 (Pharmaceutical Preparations)
RN  - VJT6J7R4TR (Rifampin)
SB  - IM
MH  - Administration, Intravenous
MH  - Administration, Oral
MH  - Animals
MH  - Drug Evaluation, Preclinical/*methods
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Pharmaceutical Preparations/metabolism
MH  - *Pharmacokinetics
MH  - Rifampin/administration & dosage/blood/pharmacokinetics
EDAT- 2012/07/14 06:00
MHDA- 2013/01/18 06:00
CRDT- 2012/07/14 06:00
PHST- 2011/12/23 00:00 [received]
PHST- 2012/05/09 00:00 [revised]
PHST- 2012/07/02 00:00 [accepted]
PHST- 2012/07/14 06:00 [entrez]
PHST- 2012/07/14 06:00 [pubmed]
PHST- 2013/01/18 06:00 [medline]
AID - S0928-0987(12)00266-7 [pii]
AID - 10.1016/j.ejps.2012.07.001 [doi]
PST - ppublish
SO  - Eur J Pharm Sci. 2012 Sep 29;47(2):444-50. doi: 10.1016/j.ejps.2012.07.001. Epub 
      2012 Jul 9.


PMID- 22789439
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20120831
IS  - 1468-2044 (Electronic)
IS  - 0003-9888 (Linking)
VI  - 97
IP  - 9
DP  - 2012 Sep
TI  - The ethical obligation to preserve fertility in the face of all therapies that
      might adversely affect it.
PG  - 767-8
LID - 10.1136/archdischild-2012-301836 [doi]
FAU - Larcher, Vic
AU  - Larcher V
AD  - Adolescent Medicine, Great Ormond Street Hospital NHS Trust, Great Ormond Street,
      London, UK. victor.larcher@gosh.nhs.uk
LA  - eng
PT  - Journal Article
DEP - 20120711
PL  - England
TA  - Arch Dis Child
JT  - Archives of disease in childhood
JID - 0372434
SB  - IM
MH  - Adult
MH  - Child, Preschool
MH  - Fertility Preservation/*ethics
MH  - Humans
MH  - Infertility/*prevention & control
MH  - Parents
MH  - Third-Party Consent/ethics
EDAT- 2012/07/14 06:00
MHDA- 2012/11/14 06:00
CRDT- 2012/07/14 06:00
PHST- 2012/07/14 06:00 [entrez]
PHST- 2012/07/14 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
AID - archdischild-2012-301836 [pii]
AID - 10.1136/archdischild-2012-301836 [doi]
PST - ppublish
SO  - Arch Dis Child. 2012 Sep;97(9):767-8. doi: 10.1136/archdischild-2012-301836. Epub
      2012 Jul 11.


PMID- 22789039
OWN - NLM
STAT- MEDLINE
DCOM- 20121226
LR  - 20170516
IS  - 1748-720X (Electronic)
IS  - 1073-1105 (Linking)
VI  - 40
IP  - 2
DP  - 2012 Summer
TI  - Pharmaceutical companies vs. the State: who is responsible for post-trial
      provision of drugs in Brazil?
PG  - 188-96
LID - 10.1111/j.1748-720X.2012.00657.x [doi]
AB  - This paper discusses the post-trial access to drugs for patients who participated
      in clinical trials in Brazil. The ethical guidance for clinical trials in Brazil 
      is arguably one of the clearest in the world in attributing to research sponsors 
      the responsibility for providing post-trial drugs to patients who participated in
      their experiments. The Federal Constitution recognizes health as a fundamental
      right to be fulfilled by the State. Based on the Brazilian constitution and on
      the National Health Council resolutions, courts have been accepting patients'
      claims and ordering the State and the pharmaceutical companies to provide these
      patients with the tested treatment in the quantity and duration they need it.
      This generous interpretation of the duties of the pharmaceutical companies and
      the State makes the Brazilian model for post-trial access unique when compared to
      the experience of other countries and thus should be followed with attention by
      future research in order to assess its consequences for patients, research
      sponsors, and the public health system.
CI  - (c) 2012 American Society of Law, Medicine & Ethics, Inc.
FAU - Wang, Daniel Wei L
AU  - Wang DW
AD  - London School of Economics and Political Science.
FAU - Ferraz, Octavio Luiz Motta
AU  - Ferraz OL
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Law Med Ethics
JT  - The Journal of law, medicine & ethics : a journal of the American Society of Law,
      Medicine & Ethics
JID - 9315583
MH  - Brazil
MH  - Drug Industry/ethics/*legislation & jurisprudence
MH  - Guidelines as Topic
MH  - Health Services Accessibility/ethics/*legislation & jurisprudence
MH  - Humans
MH  - International Cooperation
MH  - National Health Programs/ethics/*legislation & jurisprudence
MH  - Patient Rights/ethics/*legislation & jurisprudence
MH  - Research Subjects/*legislation & jurisprudence
MH  - Social Responsibility
EDAT- 2012/07/14 06:00
MHDA- 2012/12/27 06:00
CRDT- 2012/07/14 06:00
PHST- 2012/07/14 06:00 [entrez]
PHST- 2012/07/14 06:00 [pubmed]
PHST- 2012/12/27 06:00 [medline]
AID - 10.1111/j.1748-720X.2012.00657.x [doi]
PST - ppublish
SO  - J Law Med Ethics. 2012 Summer;40(2):188-96. doi:
      10.1111/j.1748-720X.2012.00657.x.


PMID- 22789017
OWN - NLM
STAT- MEDLINE
DCOM- 20130417
LR  - 20191112
IS  - 2212-3431 (Electronic)
IS  - 1872-2156 (Linking)
VI  - 6
IP  - 3
DP  - 2012 Dec
TI  - Critical overview of applications of genetic testing in sport talent
      identification.
PG  - 247-55
AB  - Talent identification for future sport performance is of paramount interest for
      many groups given the challenges of finding and costs of training potential elite
      athletes. Because genetic factors have been implicated in many performance-
      related traits (strength, endurance, etc.), a natural inclination is to consider 
      the addition of genetic testing to talent identification programs. While the
      importance of genetic factors to sport performance is generally not disputed,
      whether genetic testing can positively inform talent identification is less
      certain. The present paper addresses the science behind the genetic tests that
      are now commercially available (some under patent protection) and aimed at
      predicting future sport performance potential. Also discussed are the challenging
      ethical issues that emerge from the availability of these tests. The potential
      negative consequences associated with genetic testing of young athletes will very
      likely outweigh any positive benefit for sport performance prediction at least
      for the next several years. The paper ends by exploring the future possibilities 
      for genetic testing as the science of genomics in sport matures over the coming
      decade(s).
FAU - Roth, Stephen M
AU  - Roth SM
AD  - Department of Kinesiology, School of Public Health, University of Maryland,
      College Park, MD 20742, USA. sroth1@umd.edu
LA  - eng
PT  - Journal Article
PL  - United Arab Emirates
TA  - Recent Pat DNA Gene Seq
JT  - Recent patents on DNA & gene sequences
JID - 101299745
RN  - 0 (ACTN3 protein, human)
RN  - 0 (Genetic Markers)
RN  - 11003-00-2 (Actinin)
SB  - IM
MH  - Actinin/genetics
MH  - Aptitude/*physiology
MH  - Athletes
MH  - Exercise/physiology
MH  - Genetic Markers
MH  - Genetic Predisposition to Disease
MH  - Genetic Testing/economics/ethics/*methods
MH  - Genetic Variation
MH  - Genome, Human
MH  - Humans
MH  - Muscle Strength/genetics
MH  - Patents as Topic
MH  - Physical Fitness
MH  - Quantitative Trait, Heritable
MH  - Sports/*physiology
EDAT- 2012/07/14 06:00
MHDA- 2013/04/18 06:00
CRDT- 2012/07/14 06:00
PHST- 2012/05/05 00:00 [received]
PHST- 2012/06/21 00:00 [revised]
PHST- 2012/06/29 00:00 [accepted]
PHST- 2012/07/14 06:00 [entrez]
PHST- 2012/07/14 06:00 [pubmed]
PHST- 2013/04/18 06:00 [medline]
AID - DNAG-EPUB-20120702-2 [pii]
AID - 10.2174/187221512802717402 [doi]
PST - ppublish
SO  - Recent Pat DNA Gene Seq. 2012 Dec;6(3):247-55. doi: 10.2174/187221512802717402.


PMID- 22788552
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20120713
IS  - 1365-2702 (Electronic)
IS  - 0962-1067 (Linking)
VI  - 21
IP  - 15-16
DP  - 2012 Aug
TI  - Ethical issues of incorporating spiritual care into clinical practice.
PG  - 2099-107
LID - 10.1111/j.1365-2702.2012.04168.x [doi]
AB  - AIMS AND OBJECTIVES: The aim of this article was to analyse the scholarly
      discourse on the ethical issues of incorporating spirituality and religion into
      clinical practice. BACKGROUND: Spirituality is an important aspect of health
      care, yet the secularisation of health care presents ethical concerns for many
      health providers. Health providers may have conflicting views regarding if and
      how to offer spiritual care in the clinical setting. DESIGN: Discursive paper.
      RESULTS: The discourse analysis uncovered four themes: ethical concerns of
      omission; ethical concerns of commission; conditions under which health providers
      prefer to offer spiritual care; and strategies to integrate spiritual care.
      Ethical concerns of omission of spiritual care include lack of beneficence for
      not offering holistic care. Ethical concerns of commission are coercion and
      overstepping one's competence in offering spiritual care. Conditions under which 
      providers are more likely to offer spiritual care are if the patient has a
      terminal illness, and if the patient requests spiritual care. Strategies for
      appropriate spiritual care include listening, and remaining neutral and sensitive
      to spiritual issues. CONCLUSIONS: Health providers must be aware of both the
      concerns of omission and commission. Aristotle's golden mean, an element of
      virtue ethics, supports a more moderate approach that can be achieved by avoiding
      the imposition of one's own personal beliefs of a religious persuasion or beliefs
      of extreme secularisation, and focusing on the beneficence to the patient.
      Relevance to clinical practice. Key components for health providers in addressing
      spiritual concerns are self-reflection, provision of individualised care,
      cultural competency and communication.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Polzer Casarez, Rebecca L
AU  - Polzer Casarez RL
AD  - School of Nursing, University of Texas Health Science Center at Houston, TX
      77030, USA. rebecca.l.casarez@uth.tmc.edu
FAU - Engebretson, Joan C
AU  - Engebretson JC
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Clin Nurs
JT  - Journal of clinical nursing
JID - 9207302
MH  - Humans
MH  - Nursing Care/*ethics
MH  - *Spirituality
EDAT- 2012/07/14 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/14 06:00
PHST- 2012/07/14 06:00 [entrez]
PHST- 2012/07/14 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1111/j.1365-2702.2012.04168.x [doi]
PST - ppublish
SO  - J Clin Nurs. 2012 Aug;21(15-16):2099-107. doi: 10.1111/j.1365-2702.2012.04168.x.


PMID- 22788252
OWN - NLM
STAT- MEDLINE
DCOM- 20121221
LR  - 20211021
IS  - 1471-2458 (Electronic)
IS  - 1471-2458 (Linking)
VI  - 12
DP  - 2012 Jul 12
TI  - The epidemiology of mild cognitive impairment (MCI) and Alzheimer's disease (AD) 
      in community-living seniors: protocol of the MemoVie cohort study, Luxembourg.
PG  - 519
LID - 10.1186/1471-2458-12-519 [doi]
AB  - BACKGROUND: Cognitive impairment and Alzheimer's disease (AD) are increasingly
      considered a major public health problem. The MemoVie cohort study aims to
      investigate the living conditions or risk factors under which the normal
      cognitive capacities of the senior population in Luxembourg (>/= 65 year-old)
      evolve (1) to mild cognitive impairment (MCI) - transitory non-clinical stage -
      and (2) to AD. Identifying MCI and AD predictors undeniably constitutes a
      challenge in public health in that it would allow interventions which could
      protect or delay the occurrence of cognitive disorders in elderly people. In
      addition, the MemoVie study sets out to generate hitherto unavailable data, and a
      comprehensive view of the elderly population in the country. METHODS/DESIGN: The 
      study has been designed with a view to highlighting the prevalence in Luxembourg 
      of MCI and AD in the first step of the survey, conducted among participants
      selected from a random sample of the general population. A prospective cohort is 
      consequently set up in the second step, and appropriate follow-up of the
      non-demented participants allows improving the knowledge of the preclinical stage
      of MCI. Case-control designs are used for cross-sectional or retrospective
      comparisons between outcomes and biological or clinical factors. To ensure
      maximal reliability of the information collected, we decided to opt for
      structured face to face interviews. Besides health status, medical and family
      history, demographic and socio-cultural information are explored, as well as
      education, habitat network, social behavior, leisure and physical activities. As 
      multilingualism is expected to challenge the cognitive alterations associated
      with pathological ageing, it is additionally investigated. Data relative to motor
      function, including balance, walk, limits of stability, history of falls and
      accidents are further detailed. Finally, biological examinations, including ApoE 
      genetic polymorphism are carried out. In addition to standard blood parameters,
      the lipid status of the participants is subsequently determined from the fatty
      acid profiles in their red blood cells. The study obtained the legal and ethical 
      authorizations. DISCUSSION: By means of the multidisciplinary MemoVie study, new 
      insights into the onset of cognitive impairment during aging should be put
      forward, much to the benefit of intervention strategies as a whole.
FAU - Perquin, Magali
AU  - Perquin M
AD  - Centre d'Etudes en Sante, Centre de Recherche Public (CRP)-Sante, 1A-1B rue
      Thomas Edison, L-1445, Strassen, Luxembourg. magali.perquin@crp-sante.lu.
FAU - Schuller, Anne-Marie
AU  - Schuller AM
FAU - Vaillant, Michel
AU  - Vaillant M
FAU - Diederich, Nico
AU  - Diederich N
FAU - Bisdorff, Alexandre
AU  - Bisdorff A
FAU - Leners, Jean-Claude
AU  - Leners JC
FAU - D'Incau, Marylene
AU  - D'Incau M
FAU - Ludewig, Jean-Luc
AU  - Ludewig JL
FAU - Hoffmann, Danielle
AU  - Hoffmann D
FAU - Ulbricht, Dirk
AU  - Ulbricht D
FAU - Thoma, Stephanie
AU  - Thoma S
FAU - Dondelinger, Rene
AU  - Dondelinger R
FAU - Heuschling, Paul
AU  - Heuschling P
FAU - Couffignal, Sophie
AU  - Couffignal S
FAU - Dartigues, Jean-Francois
AU  - Dartigues JF
FAU - Lair, Marie-Lise
AU  - Lair ML
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120712
PL  - England
TA  - BMC Public Health
JT  - BMC public health
JID - 100968562
SB  - IM
MH  - Aged
MH  - Alzheimer Disease/*epidemiology
MH  - Cognitive Dysfunction/*epidemiology
MH  - Cohort Studies
MH  - Humans
MH  - *Independent Living
MH  - Luxembourg/epidemiology
MH  - Prevalence
MH  - Research Design
MH  - Risk Factors
PMC - PMC3461490
EDAT- 2012/07/14 06:00
MHDA- 2012/12/22 06:00
CRDT- 2012/07/14 06:00
PHST- 2012/04/26 00:00 [received]
PHST- 2012/05/10 00:00 [accepted]
PHST- 2012/07/14 06:00 [entrez]
PHST- 2012/07/14 06:00 [pubmed]
PHST- 2012/12/22 06:00 [medline]
AID - 1471-2458-12-519 [pii]
AID - 10.1186/1471-2458-12-519 [doi]
PST - epublish
SO  - BMC Public Health. 2012 Jul 12;12:519. doi: 10.1186/1471-2458-12-519.


PMID- 22788070
OWN - NLM
STAT- MEDLINE
DCOM- 20120807
LR  - 20120713
IS  - 0025-8105 (Print)
IS  - 0025-8105 (Linking)
VI  - 65
IP  - 3-4
DP  - 2012 Mar-Apr
TI  - [Euthanasia through history and religion].
PG  - 173-7
AB  - INTRODUCTION Euthanasia represents an ethical, social, legal and medical issue,
      which is being disputed more and more frequently worldwide. In Serbia, it is
      illegal and punishable by law and subject to a prison sentence. Euthanasia
      verbatim, meaning "good death", refers to the practice of ending a life in order 
      to relieve pain and suffering. It can be voluntary, when a person knowingly
      declares the wish to end life, and involuntary, when relatives and family make
      decisions on behalf of patients in coma. It can be active, when a person applies 
      a medical procedure to end life and passive, when medical procedures which can
      extend a patient's life are not applied. EUTHANASIA THROUGH HISTORY: The term was
      known in old Greece, and Hippocrates mentioned it in his oath, which is now taken
      by all doctors in the world, by which they pledge not to apply a medicine which
      can lead to death of the patients, nor to give such counsel. Euthanasia had its
      most vigorous impetus in the mid-20th century when it was being carried out
      deliberately in Nazi Germany. All leading religions from Christianity, over
      Buddhism, to Islam, are directly or indirectly against any kind of euthanasia.
      EUTHANASIA TODAY: At the beginning of the 21st century, euthanasia was legalized 
      in several most developed countries in the world, among them the Netherlands,
      Belgium, Germany, Switzerland, Japan, India and some American and Mexican federal
      states. The World Medical Association from 82 countries has condemned euthanasia,
      and called all medical workers who practice euthanasia to reconsider their
      attitudes and to stop this practice.
FAU - Gajic, Vladimir
AU  - Gajic V
AD  - Urgentni centar Kragujevac. drgaja@sbb.rs
LA  - srp
PT  - English Abstract
PT  - Historical Article
PT  - Journal Article
PL  - Serbia
TA  - Med Pregl
JT  - Medicinski pregled
JID - 2985249R
SB  - IM
MH  - Euthanasia/*history
MH  - History, 16th Century
MH  - History, 17th Century
MH  - History, 18th Century
MH  - History, 19th Century
MH  - History, 20th Century
MH  - History, 21st Century
MH  - History, Ancient
MH  - History, Medieval
MH  - Humans
MH  - Religion/history
EDAT- 2012/07/14 06:00
MHDA- 2012/08/08 06:00
CRDT- 2012/07/14 06:00
PHST- 2012/07/14 06:00 [entrez]
PHST- 2012/07/14 06:00 [pubmed]
PHST- 2012/08/08 06:00 [medline]
PST - ppublish
SO  - Med Pregl. 2012 Mar-Apr;65(3-4):173-7.


PMID- 22788058
OWN - NLM
STAT- MEDLINE
DCOM- 20120807
LR  - 20190923
IS  - 0025-8105 (Print)
IS  - 0025-8105 (Linking)
VI  - 65
IP  - 3-4
DP  - 2012 Mar-Apr
TI  - [Awareness detection in anaesthesia during otorhino-maxillofacial surgery using
      bispectral index-monitoring technology].
PG  - 111-4
AB  - INTRODUCTION: Awareness is characterized by intraoperative presence of
      consciousness and recollecting of the events occurring during general
      anaesthesia. The study was aimed at detecting awareness during general
      anaesthesia in otorhino-maxillofacial procedure. METHODS: The study is a part of 
      a prospective, phase IV academic study carried out at the Department for
      Otorhinolaringology, Clinical Centre of Serbia, and Maxillofacial Surgery. The
      study was approved by the Ethics Committee of the Clinical Centre of Serbia and
      performed in accordance with European Union Clinical Trials Directive. The
      evaluation included 40 patients (T-propofol and E-sevofluran group) subjected to 
      different surgical procedures (American Society ofAnesthesiologists I-III). Depth
      of anaesthesia was monitored during surgical procedures according to the
      hemodynamic parameters (blood pressure, pulse, oxygen saturation,
      electrocardiography, capnometry). Bispectral index monitoring was applied;
      however, the insight into the obtained bispectral index values was possible only 
      after the completion of the surgery when the comparison with hemodynamic values
      was performed. Modified Brice interview was postoperatively applied to the
      patients in whom awareness was suspected. RESULTS: Based on the hemodynamic
      parameter values obtained in 40 anesthetized patients, no cases of awareness were
      expected. After the completion of the surgical procedures, the recorded graphic
      and numeric bispectral index values obtained in the course of anaesthesia were
      analyzed. Higher bispectral index values (BIS > 60) were recorded in 1 T-group
      patient. CONCLUSION: It is possible to miss an awareness episode without using
      bispectral index technology monitoring during general anaesthesia in
      otorhinolaryngology and maxillofacial surgery. Bispectral index monitoring should
      be the clinical standard in general anaesthesia.
FAU - Radosic, Nadezda N
AU  - Radosic NN
AD  - Centar za anesteziju, Klinicki centar Srbije, Beograd. nacaradosic@hotmail.com
FAU - Kastratovic, Dragana A
AU  - Kastratovic DA
FAU - Tomic, Snjezana D
AU  - Tomic SD
FAU - Terzic, Milica K
AU  - Terzic MK
FAU - Markovic, Srdan Z
AU  - Markovic SZ
FAU - Milakovic, Branko D
AU  - Milakovic BD
LA  - srp
PT  - Clinical Trial, Phase IV
PT  - Journal Article
PL  - Serbia
TA  - Med Pregl
JT  - Medicinski pregled
JID - 2985249R
RN  - 0 (Anesthetics, Inhalation)
RN  - 0 (Anesthetics, Intravenous)
RN  - 0 (Methyl Ethers)
RN  - 38LVP0K73A (Sevoflurane)
RN  - YI7VU623SF (Propofol)
SB  - IM
MH  - *Anesthesia, General
MH  - Anesthetics, Inhalation
MH  - Anesthetics, Intravenous
MH  - *Awareness
MH  - *Consciousness Monitors
MH  - Female
MH  - Humans
MH  - Male
MH  - Methyl Ethers
MH  - *Monitoring, Intraoperative
MH  - Oral Surgical Procedures
MH  - Otorhinolaryngologic Surgical Procedures
MH  - Propofol
MH  - Sevoflurane
MH  - Young Adult
EDAT- 2012/07/14 06:00
MHDA- 2012/08/08 06:00
CRDT- 2012/07/14 06:00
PHST- 2012/07/14 06:00 [entrez]
PHST- 2012/07/14 06:00 [pubmed]
PHST- 2012/08/08 06:00 [medline]
AID - 10.2298/mpns1204111r [doi]
PST - ppublish
SO  - Med Pregl. 2012 Mar-Apr;65(3-4):111-4. doi: 10.2298/mpns1204111r.


PMID- 22787958
OWN - NLM
STAT- MEDLINE
DCOM- 20120723
LR  - 20191112
IS  - 1054-6863 (Print)
IS  - 1054-6863 (Linking)
VI  - 22
IP  - 1
DP  - 2012 Mar
TI  - Potter's notion of bioethics.
PG  - 59-82
AB  - In 1970 Van Rensselaer Potter was the first to use the term "bioethics" in a
      publication to advocate the development of a new discipline to address the basic 
      problems of human flourishing. This article analyzes Potter's notion of bioethics
      in order to understand its origins, sources, and substance. In early
      publications, Potter conceptualized bioethics as a bridge: between present and
      future, nature and culture, science and values, and finally between humankind and
      nature. In later publications, disappointed by a predominant focus on individual 
      and medical issues, and with a wish to underscore the need for a broader
      perspective, Potter introduced the new term "global bioethics," meant to
      transcend ethics specialties and integrate them into a new interdisciplinary
      endeavor to address global problems. A growing interest in global bioethics today
      means that Potter's original insights are more timely than ever.
FAU - ten Have, Henk A M J
AU  - ten Have HA
AD  - Center for Healthcare Ethics, Duquesne University, Pittsburgh, PA, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Kennedy Inst Ethics J
JT  - Kennedy Institute of Ethics journal
JID - 9109135
SB  - IM
MH  - *Bioethics
MH  - *Concept Formation
MH  - Ethical Analysis
MH  - Humans
MH  - *Internationality
MH  - *Social Values
EDAT- 2012/07/14 06:00
MHDA- 2012/07/24 06:00
CRDT- 2012/07/14 06:00
PHST- 2012/07/14 06:00 [entrez]
PHST- 2012/07/14 06:00 [pubmed]
PHST- 2012/07/24 06:00 [medline]
AID - 10.1353/ken.2012.0003 [doi]
PST - ppublish
SO  - Kennedy Inst Ethics J. 2012 Mar;22(1):59-82. doi: 10.1353/ken.2012.0003.


PMID- 22787734
OWN - NLM
STAT- MEDLINE
DCOM- 20120731
LR  - 20120713
IS  - 1660-9379 (Print)
IS  - 1660-9379 (Linking)
VI  - 8
IP  - 345
DP  - 2012 Jun 13
TI  - [Health care system: an ethical choice or a trade issue].
PG  - 1299
FAU - Saegesser, Philippe
AU  - Saegesser P
AD  - pg.saegesser@bluewin.ch
LA  - fre
PT  - Journal Article
TT  - Le systeme de sante: un choix ethique ou un enjeu commercial?
PL  - Switzerland
TA  - Rev Med Suisse
JT  - Revue medicale suisse
JID - 101219148
SB  - IM
MH  - Choice Behavior/physiology
MH  - Commerce/ethics/legislation & jurisprudence/methods
MH  - Delivery of Health Care/*economics/*ethics
MH  - Drug Industry/economics/*ethics/legislation & jurisprudence
MH  - For-Profit Insurance Plans/*economics/*ethics
MH  - Health Services Accessibility/economics/ethics
MH  - Humans
MH  - Patient Selection/ethics
MH  - Social Responsibility
MH  - Switzerland
EDAT- 2012/07/14 06:00
MHDA- 2012/08/01 06:00
CRDT- 2012/07/14 06:00
PHST- 2012/07/14 06:00 [entrez]
PHST- 2012/07/14 06:00 [pubmed]
PHST- 2012/08/01 06:00 [medline]
PST - ppublish
SO  - Rev Med Suisse. 2012 Jun 13;8(345):1299.


PMID- 22787689
STAT- Publisher
DA  - 20120713
PB  - Department of Veterans Affairs (US)
CTI - VA Evidence-based Synthesis Program Reports
DP  - 2012 May
BTI - Maintaining Research Integrity: A Systematic Review of the Role of the
      Institutional Review Board in Managing Conflict of Interest
AB  - Ethical integrity in the conduct of health care research is essential for
      maintaining the public trust and support of such activities. Institutional Review
      Boards (IRBs) play a critical role in maintaining the ethical integrity of
      research by reviewing research protocols to ensure, among other things, that
      research participants receive safe and ethical treatment and provide informed
      consent, and that the potential for a conflict of interest is minimized. The
      purpose of this review was to catalog the literature on issues pertaining to
      IRBs, to identify the issue with the greatest number of published studies which
      might inform VA policy, and to assess the evidence regarding that issue, which
      were conflict of interest policies and the activities of the IRB.
FAU - Shekelle, Paul G
AU  - Shekelle PG
FAU - Ruelaz, Alicia
AU  - Ruelaz A
FAU - Miake-Lye, Isomi M
AU  - Miake-Lye IM
FAU - Beroes, Jessica M
AU  - Beroes JM
FAU - Newberry, Sydney
AU  - Newberry S
LA  - eng
PT  - Review
PT  - Book
PL  - Washington (DC)
EDAT- 2012/07/13 06:00
MHDA- 2012/07/13 06:00
CDAT- 2012/07/13 06:00
AID - NBK98419 [bookaccession]


PMID- 22787258
OWN - NLM
STAT- MEDLINE
DCOM- 20120921
LR  - 20181201
IS  - 1471-1893 (Print)
IS  - 1471-1893 (Linking)
VI  - 38
IP  - 3
DP  - 2012 Jul
TI  - Is it ethical to use drospirenone-containing combined oral contraceptives?
PG  - 205-6; author reply 206-7
LID - 10.1136/jfprhc-2012-100344 [doi]
FAU - Pittrof, Rudiger
AU  - Pittrof R
LA  - eng
PT  - Letter
PT  - Comment
PL  - England
TA  - J Fam Plann Reprod Health Care
JT  - The journal of family planning and reproductive health care
JID - 101087687
RN  - 0 (Contraceptives, Oral, Combined)
RN  - 0 (Progesterone Congeners)
SB  - IM
CON - J Fam Plann Reprod Health Care. 2012 Jan;38(1):2-6. PMID: 22128104
MH  - Contraceptives, Oral, Combined/*adverse effects
MH  - Data Collection/*methods
MH  - *Data Interpretation, Statistical
MH  - Female
MH  - Humans
MH  - Progesterone Congeners/*adverse effects
MH  - Venous Thromboembolism/*chemically induced
EDAT- 2012/07/13 06:00
MHDA- 2012/09/22 06:00
CRDT- 2012/07/13 06:00
PHST- 2012/07/13 06:00 [entrez]
PHST- 2012/07/13 06:00 [pubmed]
PHST- 2012/09/22 06:00 [medline]
AID - jfprhc-2012-100344 [pii]
AID - 10.1136/jfprhc-2012-100344 [doi]
PST - ppublish
SO  - J Fam Plann Reprod Health Care. 2012 Jul;38(3):205-6; author reply 206-7. doi:
      10.1136/jfprhc-2012-100344.


PMID- 22786950
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 4
DP  - 2012
TI  - A multidisciplinary intervention to facilitate return to work in cancer patients:
      intervention protocol and design of a feasibility study.
LID - 10.1136/bmjopen-2012-001321 [doi]
LID - e001321 [pii]
AB  - INTRODUCTION: Returning to work can be problematic for cancer survivors due to
      suboptimal workplace support, a heavy workload, decreased physical functioning
      and fatigue. The timely and permanent return to work (RtW) of cancer patients
      favourably influences quality of life and economic independence.
      Multidisciplinary interventions aimed at timely and enduring RtW are lacking. The
      objectives of this article are (1) to describe the protocol of an intervention
      aimed at RtW of cancer patients, comprising of counselling by an oncological
      occupational physician and supervised physical exercise in a clinical setting
      during treatment and (2) to present the design of the study aimed at evaluating
      the feasibility of this intervention. METHODS AND ANALYSIS: The intervention
      comprises three counselling sessions with an oncological occupational physician
      and a 12-week moderate-to-high intensity physical exercise programme, starting at
      the onset of chemotherapy. The intervention is aimed at cancer patients treated
      with curative intent, aged 18-60 years, employed and on sick leave. It will take 
      place in two large medical centres in the Netherlands. The feasibility of the
      intervention will be evaluated as follows: the number of sessions, topics
      discussed and exercises executed will be registered by care providers; patients' 
      and care providers' opinions will be assessed by questionnaires and interviews,
      respectively; and the proportion of invited patients that participated will be
      calculated. ETHICS AND DISSEMINATION: The study results will be used for
      optimising the intervention content and may serve as a foundation for future
      implementation. The Medical Ethics Committees of the Academic Medical Center and 
      the participating medical centres approved the study protocol.
FAU - Groeneveld, Iris F
AU  - Groeneveld IF
AD  - Coronel Institute of Occupational Health, Academic Medical Center, University of 
      Amsterdam, Amsterdam, The Netherlands.
FAU - de Boer, Angela G E M
AU  - de Boer AG
FAU - Frings-Dresen, Monique H W
AU  - Frings-Dresen MH
LA  - eng
PT  - Journal Article
DEP - 20120710
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3400074
EDAT- 2012/07/13 06:00
MHDA- 2012/07/13 06:01
CRDT- 2012/07/13 06:00
PHST- 2012/07/13 06:00 [entrez]
PHST- 2012/07/13 06:00 [pubmed]
PHST- 2012/07/13 06:01 [medline]
AID - bmjopen-2012-001321 [pii]
AID - 10.1136/bmjopen-2012-001321 [doi]
PST - epublish
SO  - BMJ Open. 2012 Jul 10;2(4). pii: bmjopen-2012-001321. doi:
      10.1136/bmjopen-2012-001321. Print 2012.


PMID- 22786815
OWN - NLM
STAT- MEDLINE
DCOM- 20130527
LR  - 20211021
IS  - 1097-0258 (Electronic)
IS  - 0277-6715 (Linking)
VI  - 31
IP  - 29
DP  - 2012 Dec 20
TI  - Identifying combined design and analysis procedures in two-stage trials with a
      binary end point.
PG  - 3874-84
LID - 10.1002/sim.5468 [doi]
AB  - Two-stage trial designs provide the flexibility to stop early for efficacy or
      futility and are popular because they have a smaller sample size on average than 
      a traditional trial has with the same type I and II error rates. This makes them 
      financially attractive but also has the ethical benefit of reducing, in the long 
      run, the number of patients who are given ineffective treatments. Designs that
      minimise the expected sample size are often referred to as 'optimal'. However,
      two-stage designs can impart a substantial bias into the parameter estimate at
      the end of the trial. In this paper, we argue that the expected performance of
      one's chosen estimation method should also be considered when deciding on a
      two-stage trial design. We review the properties of standard and bias-adjusted
      maximum likelihood estimators as well as mean and median unbiased estimators. We 
      then identify optimal two-stage design and analysis procedures that balance
      projected sample size considerations with those of estimator performance. We make
      available software to implement this new methodology.
CI  - Copyright (c) 2012 John Wiley & Sons, Ltd.
FAU - Bowden, Jack
AU  - Bowden J
AD  - MRC Biostatistics Unit, Cambridge, UK. jack.bowden@mrc-bsu.ac.uk
FAU - Wason, James
AU  - Wason J
LA  - eng
GR  - MR/J004979/1/MRC_/Medical Research Council/United Kingdom
GR  - G0800860/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120711
PL  - England
TA  - Stat Med
JT  - Statistics in medicine
JID - 8215016
SB  - IM
MH  - Bias
MH  - Clinical Trials as Topic/*statistics & numerical data
MH  - Drug Discovery
MH  - Endpoint Determination
MH  - Humans
MH  - Likelihood Functions
MH  - *Models, Statistical
MH  - Neoplasms/drug therapy
MH  - Research Design/*statistics & numerical data
PMC - PMC3546375
EDAT- 2012/07/13 06:00
MHDA- 2013/05/29 06:00
CRDT- 2012/07/13 06:00
PHST- 2011/09/13 00:00 [received]
PHST- 2012/05/07 00:00 [accepted]
PHST- 2012/07/13 06:00 [entrez]
PHST- 2012/07/13 06:00 [pubmed]
PHST- 2013/05/29 06:00 [medline]
AID - 10.1002/sim.5468 [doi]
PST - ppublish
SO  - Stat Med. 2012 Dec 20;31(29):3874-84. doi: 10.1002/sim.5468. Epub 2012 Jul 11.


PMID- 22785625
OWN - NLM
STAT- MEDLINE
DCOM- 20130101
LR  - 20120809
IS  - 1049-7323 (Print)
IS  - 1049-7323 (Linking)
VI  - 22
IP  - 9
DP  - 2012 Sep
TI  - Ethics and research among persons with disabilities in long-term care.
PG  - 1284-97
LID - 10.1177/1049732312449389 [doi]
AB  - In this article, I reveal the arguments used to gain ethics approval to do
      research among persons with disabilities in adult residential care in New
      Brunswick and the specific ways I planned to act in their best interests. I also 
      discuss the unexpected dilemmas encountered in the field and my efforts to
      resolve them. These dilemmas included determining the capacity of the persons in 
      care to assent to be interviewed, addressing the propensity for acquiescence,
      dealing with anonymity and confidentiality issues, finding the optimum contexts
      for interviews, preparing participants for when I would leave the field,
      negotiating full disclosure as the mother of an adult with disabilities in
      long-term care, and ensuring that no persons under the auspices of the Office of 
      the Public Trustee in New Brunswick participated in this research. I conclude
      that specific efforts should continue to be made to include persons with
      disabilities in future research.
FAU - Morrisey, Barbara
AU  - Morrisey B
AD  - Department of Sociology, University of New Brunswick, Fredericton, New Brunswick,
      Canada. u2nmz@unb.ca
LA  - eng
PT  - Journal Article
DEP - 20120711
PL  - United States
TA  - Qual Health Res
JT  - Qualitative health research
JID - 9202144
MH  - Adult
MH  - Aged
MH  - Confidentiality/*psychology
MH  - Decision Making
MH  - Disabled Persons/psychology/*rehabilitation
MH  - *Ethics, Research
MH  - Female
MH  - Health Services Research/*methods
MH  - Humans
MH  - Interview, Psychological
MH  - Long-Term Care/ethics/*psychology
MH  - Male
MH  - Middle Aged
MH  - Qualitative Research
MH  - Residential Facilities
MH  - Risk Assessment
MH  - Truth Disclosure/*ethics
MH  - Young Adult
EDAT- 2012/07/13 06:00
MHDA- 2013/01/02 06:00
CRDT- 2012/07/13 06:00
PHST- 2012/07/13 06:00 [entrez]
PHST- 2012/07/13 06:00 [pubmed]
PHST- 2013/01/02 06:00 [medline]
AID - 1049732312449389 [pii]
AID - 10.1177/1049732312449389 [doi]
PST - ppublish
SO  - Qual Health Res. 2012 Sep;22(9):1284-97. doi: 10.1177/1049732312449389. Epub 2012
      Jul 11.


PMID- 22785158
OWN - NLM
STAT- MEDLINE
DCOM- 20130708
LR  - 20191210
IS  - 1477-1128 (Electronic)
IS  - 1463-4236 (Linking)
VI  - 14
IP  - 1
DP  - 2013 Jan
TI  - Health visitor professional education and post-qualification clinical
      supervision: how well does it equip practitioners for dealing with ethical
      tensions associated with promoting the public health agenda to individual
      clients?
PG  - 90-102
LID - 10.1017/S1463423612000278 [doi]
AB  - AIM: To explore how well professional education and post-qualification clinical
      supervision support equips health visitors to deal with ethical tensions
      associated with implementing the public health agenda while also being responsive
      to individual clients. BACKGROUND: Current health policy in England gives health 
      visitors a key role in implementing the government's public health agenda. Health
      visitors are also required by their Professional Code to respond to the
      health-related concerns and preferences of their individual clients. This
      generates a number of public health-related ethical tensions. METHODS:
      Exploratory cross-sectional qualitative (interpretive) study using 29
      semi-structured individual interviews with health visitors, practice teachers and
      university lecturers exploring how well health visitors' professional education
      and post-qualification clinical supervision support equips them for dealing with 
      these ethical tensions and whether they thought further ethics education was
      needed. Interviews were audio-recorded, transcribed and analysed thematically
      using a Framework approach. FINDINGS: Health visitors' professional education did
      not always equip them to deal with ethical tensions, which arose from delivering 
      public health interventions to their clients. However, the majority of
      participants thought that ethics could not be taught in a way that would equip
      health visitors for every situation and that ongoing post-qualification clinical 
      supervision support was also needed, particularly in the first year after
      qualifying. The amount of post-qualification support available to practising
      health visitors was variable with some health visitors unable to access such
      support due to their working circumstances and pressures on staff time.
      Literature on the ethical tensions associated with evidence-based practice;
      public health ethics and ethics of care might be useful for health visitors in
      gaining greater understanding of the ethical tensions they face. This could be
      introduced as part of health visitors' professional education or on
      post-qualification study days.
FAU - Greenway, Julie C
AU  - Greenway JC
AD  - Centre for Ethics in Medicine, University of Bristol, Bristol, UK.
      julie.greenway@blueyonder.co.uk
FAU - Entwistle, Vikki A
AU  - Entwistle VA
FAU - Termeulen, Ruud
AU  - Termeulen R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120712
PL  - England
TA  - Prim Health Care Res Dev
JT  - Primary health care research & development
JID - 100897390
SB  - IM
MH  - *Community Health Nursing/education/organization & administration
MH  - *Conflict, Psychological
MH  - Cross-Sectional Studies
MH  - Delivery of Health Care/*ethics
MH  - England
MH  - Female
MH  - *Health Policy
MH  - Humans
MH  - Male
MH  - *Public Health
MH  - Qualitative Research
MH  - State Medicine
EDAT- 2012/07/13 06:00
MHDA- 2013/07/09 06:00
CRDT- 2012/07/13 06:00
PHST- 2012/07/13 06:00 [entrez]
PHST- 2012/07/13 06:00 [pubmed]
PHST- 2013/07/09 06:00 [medline]
AID - S1463423612000278 [pii]
AID - 10.1017/S1463423612000278 [doi]
PST - ppublish
SO  - Prim Health Care Res Dev. 2013 Jan;14(1):90-102. doi: 10.1017/S1463423612000278. 
      Epub 2012 Jul 12.


PMID- 22784399
OWN - NLM
STAT- MEDLINE
DCOM- 20130830
LR  - 20171116
IS  - 1477-1128 (Electronic)
IS  - 1463-4236 (Linking)
VI  - 14
IP  - 2
DP  - 2013 Apr
TI  - A questionnaire survey of patients and carers of patients prescribed Sativex as
      an unlicensed medicine.
PG  - 192-9
LID - 10.1017/S1463423612000333 [doi]
AB  - AIM: To identify the areas of daily function most affected by the introduction of
      Sativex, a cannabis-based medicine, and the impact on caregivers and people with 
      multiple sclerosis (MS). BACKGROUND: Cannabinoid medicines have recently become
      available on prescription in several parts of the world, principally for the
      treatment of spasticity in people with MS. Their efficacy and safety have been
      demonstrated in the setting of randomised controlled clinical trials. Results of 
      such studies may not always reflect the wider effectiveness that a medicine shows
      when used in clinical practice. METHODS: A short questionnaire survey consisting 
      mostly of multiple-choice questions, along with some free-text questions aimed at
      the patient and primary caregiver (ie, partner, mother, nurse or outside carer). 
      The questionnaire was developed in consultation with a patient representative
      organisation, field tested, ethics approval gained, then distributed to
      prescribers in the United Kingdom, with the request that they in turn forward it 
      to any patients who had received repeat prescriptions for Sativex within the
      previous 16 weeks. Patients were seen in both a primary care (general practice)
      and a secondary care (hospital) setting. There was no control group in this
      study. Most patients had MS, and the primary reasons for using Sativex were
      spasticity and pain. FINDINGS: The response rate was 57%, with 124 questionnaires
      returned. The majority of respondents and their caregivers reported improvements 
      across a range of daily functional activities, alongside a reduction in the use
      of concomitant anti-spasticity medication and in the use of other healthcare
      resources.
FAU - Notcutt, William G
AU  - Notcutt WG
AD  - Pain Research Unit, James Paget University Hospital, Great Yarmouth, Norfolk, UK.
      William.Notcutt@JPAGET.NHS.UK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120712
PL  - England
TA  - Prim Health Care Res Dev
JT  - Primary health care research & development
JID - 100897390
RN  - 0 (Drug Combinations)
RN  - 0 (Plant Extracts)
RN  - 19GBJ60SN5 (Cannabidiol)
RN  - 7J8897W37S (Dronabinol)
RN  - K4H93P747O (nabiximols)
SB  - IM
MH  - *Activities of Daily Living
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cannabidiol
MH  - Caregivers/statistics & numerical data
MH  - Dronabinol
MH  - Drug Combinations
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/complications/*drug therapy/physiopathology
MH  - Muscle Spasticity/*drug therapy/etiology
MH  - Neuralgia/*drug therapy/etiology
MH  - Off-Label Use
MH  - Phytotherapy
MH  - Plant Extracts/*administration & dosage/therapeutic use
MH  - Practice Patterns, Physicians'/statistics & numerical data
MH  - Sleep/drug effects
MH  - Surveys and Questionnaires
MH  - United Kingdom
EDAT- 2012/07/13 06:00
MHDA- 2013/08/31 06:00
CRDT- 2012/07/13 06:00
PHST- 2012/07/13 06:00 [entrez]
PHST- 2012/07/13 06:00 [pubmed]
PHST- 2013/08/31 06:00 [medline]
AID - S1463423612000333 [pii]
AID - 10.1017/S1463423612000333 [doi]
PST - ppublish
SO  - Prim Health Care Res Dev. 2013 Apr;14(2):192-9. doi: 10.1017/S1463423612000333.
      Epub 2012 Jul 12.


PMID- 22784023
OWN - NLM
STAT- MEDLINE
DCOM- 20130711
LR  - 20130131
IS  - 1937-3376 (Electronic)
IS  - 1937-3368 (Linking)
VI  - 19
IP  - 1
DP  - 2013 Feb
TI  - Regenerative urology clinical trials: an ethical assessment of road blocks and
      solutions.
PG  - 41-7
LID - 10.1089/ten.TEB.2012.0136 [doi]
AB  - Tissue engineering--part of regenerative medicine--is a promising technology that
      could potentially offer elegant solutions to urogenital defects, but so far, it
      has fallen short of its potential. Within experimental studies for bladder and
      urethra reconstructions, two clinical applications have been described, but
      extension of these techniques to the broader urological patient population has
      not happened so far. In this article, we aim to identify the ethical road blocks 
      in the clinical evaluation of tissue-engineered products under the European
      Medicines Agency and Food and Drug Administration regulations for pediatric
      urological conditions and, ultimately, to recommend strategies to overcome them. 
      The use of human tissue-engineered products (HTEPs) to treat children with
      congenital urogenital defects poses challenges in the clinical testing phase,
      connected to three features of the application of this treatment in this patient 
      group: (1) those associated with the product, namely, the multifaceted complexity
      of the HTEP; (2) those connected to the procedure, namely, the lack of a
      randomized controlled trial (RCT)-tested gold standard to compare the new
      treatment to and difficulties surrounding standardization of the treatment
      protocol; and (3) the patient's young age and associated problems concerning
      possible long-term effects and the informed consent process. Due to these
      problems, a conventional RCT is not the methodology of choice to evaluate this
      treatment in this patient group. The unpredictability of HTEPs necessitates
      stringent and long-term surveillance and registry to ensure the safety of
      patients treated with these products.
FAU - Oerlemans, Anke J M
AU  - Oerlemans AJ
AD  - Scientific Institute for Quality of Healthcare, Section Ethics, Philosophy and
      History of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The
      Netherlands. a.oerlemans@iq.umcn.nl
FAU - Feitz, Wouter F J
AU  - Feitz WF
FAU - van Leeuwen, Evert
AU  - van Leeuwen E
FAU - Dekkers, Wim J M
AU  - Dekkers WJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120814
PL  - United States
TA  - Tissue Eng Part B Rev
JT  - Tissue engineering. Part B, Reviews
JID - 101466660
SB  - IM
MH  - Child
MH  - Clinical Trials as Topic/*ethics
MH  - Guided Tissue Regeneration/*ethics
MH  - Humans
MH  - Netherlands
MH  - Regenerative Medicine/*ethics
MH  - Tissue Engineering/*ethics
MH  - Urogenital Abnormalities/*surgery
MH  - Urology/*ethics
EDAT- 2012/07/13 06:00
MHDA- 2013/07/13 06:00
CRDT- 2012/07/13 06:00
PHST- 2012/07/13 06:00 [entrez]
PHST- 2012/07/13 06:00 [pubmed]
PHST- 2013/07/13 06:00 [medline]
AID - 10.1089/ten.TEB.2012.0136 [doi]
PST - ppublish
SO  - Tissue Eng Part B Rev. 2013 Feb;19(1):41-7. doi: 10.1089/ten.TEB.2012.0136. Epub 
      2012 Aug 14.


PMID- 22783731
OWN - NLM
STAT- MEDLINE
DCOM- 20120802
LR  - 20120928
IS  - 0370-0747 (Print)
IS  - 0370-0747 (Linking)
VI  - 42
IP  - 1
DP  - 2012
TI  - [Modern biomaterials as hemostatic dressings in kidney nephron sparing surgery
      (NSS)--murine model. A preliminary report].
PG  - 35-43
AB  - INTRODUCTION: Kidney cancer is now days, one of the main problems in oncological 
      urology. More frequent cases detection of this type of cancer and the
      implementation of modern methods of treatment, involves the public and good
      diagnostic radiological imaging methods. Approximately 40% of renal tumors are
      detected clinically as a changes in T1N0M0 stage. This means that in these
      patients, surgery can be performed using the method of nephron sparing surgery
      (NSS), far from consisting the implementation of radical nephrectomy.
      Unfortunately, despite the saving nature of this type of treatment, NSS methods
      are associated with local recurrence of tumor formation. Another problem is intra
      operative bleeding, that's why in order to stop this negative process surgeons
      currently use hemostatic dressings. Potentially and clinically significant
      solution could be a combination of this two main problematics points of concern, 
      through the use of modern biomaterials coated on oncostatic substances as a
      haemostatic dressings, to the prevention of tumor recurrence. AIM OF THE WORK:
      The aim of this work, was to present preliminary report of the use of advanced
      biomaterials, as haemostatic dressings in an experimental technique of nephron
      sparing surgery on an murine model. MATERIAL AND METHODS: In the experiment we
      use two types of biomaterials and the standard haemostatic dressing used in the
      nephron sparing surgery (NSS) as a control. We use a polycaprolactone biomaterial
      obtained by electrospinning. As a second type of biomaterial, we use a
      homogeneous material with a structure similar to wool, also obtained from medical
      polycaprolactone by electrospinning. As an murine (in vivo) model in the study,
      we use 10 C57BL/J mice (with the local ethical committee permission). 8 mice were
      used in the present study, 2 mice were constituted as a separate control for
      obtaining the bleeding data. Kidney melanoma cells were implanted under the
      C57B1/J B16 mouse kidney fibrous capsule, one week before NSS. After 3 weeks the 
      animals were sacrificed for comparison of hemostatic dressings function. RESULTS:
      Used biomaterials fulfilled their role as a hameostatic dresings. The material
      (Type I) was convenient and good for suturing. Haemostatic action times were as
      follows: (Type I) - 30 seconds. (Type III) - 50 seconds. In the control group
      were also observed, a proper hemostatic function after 30 seconds. In sectional
      observation was also found in 3 kidneys section preparation samples, a local
      tumor recurrence and metastasis to the other tissues of the abdomen. CONCLUSION: 
      The tested biomaterials fulfill their hemostatic effect on kidney after NSS,
      without any significant difference acording to a standard hemostatic dressing
      used clinically. This data may be a potential factor for use in further studies
      to determine their continued relevance in the prevention of local tumor
      recurrence after nephron sparing surgery.
FAU - Nowacki, Maciej
AU  - Nowacki M
AD  - Zaklad Inzynierii Tkankowej, Collegium Medicum im. Ludwika Rydygiera w
      Bydgoszczy, Uniwersytet Mikolaja Kopernika w Toruniu. maciej.s.nowacki@gmail.com
FAU - Jundzill, Arkadiusz
AU  - Jundzill A
FAU - Bieniek, Milosz
AU  - Bieniek M
FAU - Kowalczyk, Tomasz
AU  - Kowalczyk T
FAU - Kloskowski, Tomasz
AU  - Kloskowski T
FAU - Drewa, Tomasz
AU  - Drewa T
LA  - pol
PT  - English Abstract
PT  - Journal Article
TT  - Nowoczesne biomaterialy jako opatrunki hemostatyczne w chirurgii oszczedzajacej
      miazsz nerki--model zwierzecy. Doniesienie wstepne.
PL  - Poland
TA  - Polim Med
JT  - Polimery w medycynie
JID - 7509477
RN  - 0 (Biocompatible Materials)
RN  - 0 (Hemostatics)
RN  - 0 (Polyesters)
RN  - 24980-41-4 (polycaprolactone)
SB  - IM
MH  - Animals
MH  - *Bandages
MH  - *Biocompatible Materials
MH  - Disease Models, Animal
MH  - *Hemostatics
MH  - Kidney/blood supply/*surgery
MH  - Kidney Neoplasms/blood supply/*surgery
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neoplasm Recurrence, Local/prevention & control
MH  - Nephrons/surgery
MH  - Organ Sparing Treatments
MH  - *Polyesters
MH  - Postoperative Hemorrhage/*prevention & control
MH  - Wool
EDAT- 2012/07/13 06:00
MHDA- 2012/08/03 06:00
CRDT- 2012/07/13 06:00
PHST- 2012/07/13 06:00 [entrez]
PHST- 2012/07/13 06:00 [pubmed]
PHST- 2012/08/03 06:00 [medline]
PST - ppublish
SO  - Polim Med. 2012;42(1):35-43.


PMID- 22783595
OWN - NLM
STAT- MEDLINE
DCOM- 20121031
LR  - 20120712
IS  - 2067-2993 (Print)
IS  - 2067-2993 (Linking)
VI  - 61
IP  - 2
DP  - 2012 Apr-Jun
TI  - [Ethics in publishing medical papers].
PG  - 74-7
FAU - Strambu, Irina
AU  - Strambu I
LA  - rum
PT  - Editorial
TT  - Etica in publicarea articolelor medicale.
PL  - Romania
TA  - Pneumologia
JT  - Pneumologia (Bucharest, Romania)
JID - 100941067
SB  - IM
MH  - Biomedical Research/standards
MH  - Congresses as Topic
MH  - Ethics, Medical
MH  - Humans
MH  - Periodicals as Topic/*ethics/*standards
MH  - Publishing/*ethics/*standards
MH  - Romania
EDAT- 2012/07/13 06:00
MHDA- 2012/11/01 06:00
CRDT- 2012/07/13 06:00
PHST- 2012/07/13 06:00 [entrez]
PHST- 2012/07/13 06:00 [pubmed]
PHST- 2012/11/01 06:00 [medline]
PST - ppublish
SO  - Pneumologia. 2012 Apr-Jun;61(2):74-7.


PMID- 22776530
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20220318
IS  - 1440-172X (Electronic)
IS  - 1322-7114 (Linking)
VI  - 18 Suppl 2
DP  - 2012 Jul
TI  - Cross-cultural research: challenge and competence.
PG  - 28-37
LID - 10.1111/j.1440-172X.2012.02026.x [doi]
AB  - Increasing globalization, population diversity and health disparities among
      non-dominant cultures necessitate cross-cultural research. Research with other
      cultures is fraught with challenges that must be addressed by the competent
      cross-cultural researcher. Areas for consideration include choice of research
      foci, ethical concerns, cultural adaptation of research measurements and
      interventions, participant recruitment and retention, strategies for data
      collection and analysis, dissemination of findings and perspectives of time.
      Approaches to dealing with these challenges are addressed, with an emphasis on
      community-based participatory research.
CI  - (c) 2012 Blackwell Publishing Asia Pty Ltd.
FAU - Clark, Mary Jo
AU  - Clark MJ
AD  - Hahn School of Nursing and Health Science, University of San Diego, San Diego,
      California 92110, USA. clark@sandiego.edu
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Int J Nurs Pract
JT  - International journal of nursing practice
JID - 9613615
MH  - Community-Based Participatory Research
MH  - *Cross-Cultural Comparison
MH  - *Cultural Competency
MH  - Cultural Diversity
MH  - Female
MH  - Humans
MH  - Male
EDAT- 2012/07/13 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/11 06:00
PHST- 2012/07/11 06:00 [entrez]
PHST- 2012/07/13 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1111/j.1440-172X.2012.02026.x [doi]
PST - ppublish
SO  - Int J Nurs Pract. 2012 Jul;18 Suppl 2:28-37. doi:
      10.1111/j.1440-172X.2012.02026.x.


PMID- 22783463
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2008-8213 (Electronic)
IS  - 2008-7802 (Linking)
VI  - 3
IP  - 6
DP  - 2012 Jun
TI  - Preventive medicine in the older patient: a United kingdom perspective.
PG  - 379-85
AB  - Preventive Medicine in the elderly is often regarded as a redundant concept and
      pre-existing opinions are barriers in the provision of this service. This article
      explores the concepts of preventive medicine in the elderly from a United Kingdom
      perspective and examines current trends, opinions and sets out a path for the
      future. In particular it focusses on the theories of morbidity associated with
      ageing, economic viability of providing preventive medicine care for the older
      person and attempts to seek redress for the current situation.
FAU - Kakar, Puneet
AU  - Kakar P
AD  - Specialist Registrar, Geriatrics, Stroke and Medicine, Imperial College
      Healthcare NHS Trust, London.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Int J Prev Med
JT  - International journal of preventive medicine
JID - 101535380
PMC - PMC3389434
OTO - NOTNLM
OT  - Preventive medicine
OT  - compression of morbidity
OT  - ethical
EDAT- 2012/07/12 06:00
MHDA- 2012/07/12 06:01
CRDT- 2012/07/12 06:00
PHST- 2011/08/30 00:00 [received]
PHST- 2011/11/15 00:00 [accepted]
PHST- 2012/07/12 06:00 [entrez]
PHST- 2012/07/12 06:00 [pubmed]
PHST- 2012/07/12 06:01 [medline]
PST - ppublish
SO  - Int J Prev Med. 2012 Jun;3(6):379-85.


PMID- 22782836
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20120711
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Linking)
VI  - 903
DP  - 2012
TI  - Sexually transmitted diseases: reflections on metaphors and ethics.
PG  - 419-35
LID - 10.1007/978-1-61779-937-2_29 [doi]
AB  - Sexually transmitted diseases (STDs) are probably the most tabooed diseases we
      know. The taboos and the related stigmata shape patients reality and influence
      significantly health care policies, medical research, and actual problems in
      medical ethics. To better understand these complex influences of ancient but
      still powerful taboos, related metaphors associated with illness and disease are 
      analyzed according to their historical development and actual impact on society. 
      It becomes obvious that research and health care policies cannot be satisfyingly 
      successful in helping people affected by STDs as long as they do not take the
      mechanisms of taboos and associated metaphors into account.
FAU - Badura-Lotter, Gisela
AU  - Badura-Lotter G
AD  - Institute of the History, Philosophy and Ethics of Medicine, Ulm University, Ulm,
      Germany. Gisela.badura@uni-ulm.de
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
SB  - IM
MH  - *Disease Management
MH  - Female
MH  - Homosexuality/ethics
MH  - Humans
MH  - Male
MH  - Metaphor
MH  - Privacy
MH  - Sexual Behavior/*ethics
MH  - Sexually Transmitted Diseases/epidemiology/prevention &
      control/*psychology/*therapy
MH  - *Taboo
EDAT- 2012/07/12 06:00
MHDA- 2012/11/14 06:00
CRDT- 2012/07/12 06:00
PHST- 2012/07/12 06:00 [entrez]
PHST- 2012/07/12 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
AID - 10.1007/978-1-61779-937-2_29 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2012;903:419-35. doi: 10.1007/978-1-61779-937-2_29.


PMID- 22782078
OWN - NLM
STAT- MEDLINE
DCOM- 20121206
LR  - 20211021
IS  - 1438-8871 (Electronic)
IS  - 1438-8871 (Linking)
VI  - 14
IP  - 4
DP  - 2012 Jul 10
TI  - Impact of the presence of medical equipment in images on viewers' perceptions of 
      the trustworthiness of an individual on-screen.
PG  - e100
LID - 10.2196/jmir.1986 [doi]
AB  - BACKGROUND: It is now common practice for doctors to consult patients by means
      other than face-to-face, often appearing before the patient on a computer screen.
      Also, many websites are using depictions of health professionals to increase the 
      credibility of their services. Being trustworthy is an essential attribute for
      successful ehealth services. Little is known about which depicted accessories
      make a health professional appear more trustworthy. OBJECTIVE: To estimate the
      odds of an individual on-screen being rated trustworthy when viewed in a static
      image holding or wearing specific items of medical equipment. METHODS: We
      surveyed consecutive people attending community pharmacies to collect
      prescriptions in Western Australia. Respondents were presented with a series of
      10 photographs, generated at random, of a man with varying numbers and
      combinations of medical equipment: stethoscope, reflex hammer, surgical scrubs,
      otoscope, and pen. They were then invited to rate the man as honest, trustworthy,
      honorable, moral, ethical, or genuine, or a combination of these, on the Source
      Credibility Scale. RESULTS: A total of 168 of 250 people gave informed consent,
      for a participation rate of 67.2%. There were 102 female and 66 male respondents.
      Of the 168 respondents, 96 (57%) were born in Australia and 102 (60.7%) were
      attending medical practices with more than one general practitioner. The mean age
      of respondents was 47 (SD 16) years (range 26-92 years). When only 1 item was
      present in an image, the stethoscope was associated with the highest odds for the
      person being considered honest (odds ratio [OR] 2.6, 95% confidence interval [CI]
      1.6-4.3), trustworthy (OR 2.3, 95% CI 1.4-3.8), honorable (OR 2.7, 95% CI
      1.6-4.5), moral (OR 2.4 95% CI 1.4-4.1), ethical (OR 2.6, 95% CI 1.5-4.6), and
      genuine (OR 1.8, 95% CI 1.0-3.1). The presence of a stethoscope increased the
      odds of the person being rated in a positive light in all photographs in which it
      was included. CONCLUSIONS: When an individual is portrayed in a static image,
      concurrent presentation of 3 or more items of medical equipment, and especially a
      stethoscope, is likely to exert a positive influence on the viewers' perceptions 
      of the qualities of the person depicted.
FAU - Jiwa, Moyez
AU  - Jiwa M
AD  - Curtin Health Innovation Research Institute, Curtin University, Perth, Western
      Australia, Australia. m.jiwa@curtin.edu.au
FAU - Millett, Stephan
AU  - Millett S
FAU - Meng, Xingqiong
AU  - Meng X
FAU - Hewitt, Vivien M
AU  - Hewitt VM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120710
PL  - Canada
TA  - J Med Internet Res
JT  - Journal of medical Internet research
JID - 100959882
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Equipment and Supplies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Perception
MH  - Remote Consultation
MH  - *Telemedicine/ethics
MH  - Trust
MH  - Western Australia
PMC - PMC3409609
EDAT- 2012/07/12 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/12 06:00
PHST- 2011/11/07 00:00 [received]
PHST- 2012/04/29 00:00 [accepted]
PHST- 2012/02/09 00:00 [revised]
PHST- 2012/07/12 06:00 [entrez]
PHST- 2012/07/12 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - v14i4e100 [pii]
AID - 10.2196/jmir.1986 [doi]
PST - epublish
SO  - J Med Internet Res. 2012 Jul 10;14(4):e100. doi: 10.2196/jmir.1986.


PMID- 22781527
OWN - NLM
STAT- MEDLINE
DCOM- 20130320
LR  - 20120711
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 92
IP  - 13
DP  - 2012 Apr 3
TI  - [A comparison of ultrasonography versus traditional approach for caudal block in 
      children].
PG  - 882-5
AB  - OBJECTIVE: To apply ultrasonic technology in positioning and monitoring for
      pediatric caudal blocks and compare it with traditional landmark approach and
      Swoosh test. METHODS: After obtaining the approval of hospital ethics committee
      and written parental informed consent, a total of 102 American Society of
      Anesthesiologists (ASA) I-II pediatric patients aged from 1 month to 8 years and 
      scheduled for urologic or perineal surgery were recruited. Patients were randomly
      divided into 2 groups: ultrasound group (n = 52) and control group (n = 50). The 
      sites of sacral cornu and sacral hiatus were determined by ultrasonic imaging or 
      classic method of anatomical surface landmarks. Patients of two groups were
      punctured according to the scheduled site. Local anesthetic was injected slowly
      into caudal space after a successful caudal puncture and the positive reaction in
      caudal space was monitored simultaneously by ultrasound and classic swoosh test. 
      The observational results and relevant date were recorded. RESULTS: In ultrasound
      and control groups, the number of puncture attempts was 1.10 +/- 0.30 vs 1.56 +/-
      0.63, the duration of puncture (1.40 +/- 0.39) vs (3.23 +/- 1.23) min, the
      success rate at the first puncture attempt 90.4% vs 66% and the total puncture
      success rate 100% vs 92% respectively. After the injection of local anesthetic,
      the positive reaction rate of ultrasonography and swoosh test was 97.96% vs
      62.24% respectively. All of above results in ultrasound group were superior to
      those in control group or with classic test. And the difference had statistical
      significance (P < 0.01). CONCLUSION: Ultrasonic positioning and monitoring for
      pediatric caudal block is both scientific and reasonable. The positioning
      detected by ultrasonic imaging is accurate and the monitoring results of
      ultrasound are reliable. It is obviously superior to traditional method and has
      clinical application values for caudal block in children.
FAU - Liu, Jin-zhu
AU  - Liu JZ
AD  - Department of Anesthesiology, Tianjin Children's Hospital, Tianjin 300074, China.
      drljzh@sina.com
FAU - Wu, Xue-qing
AU  - Wu XQ
FAU - Li, Rong
AU  - Li R
FAU - Zhang, Yan-jun
AU  - Zhang YJ
LA  - chi
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
SB  - IM
MH  - Anesthesia, Caudal/*methods
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - *Sacrum
MH  - *Ultrasonography
EDAT- 2012/07/12 06:00
MHDA- 2013/03/21 06:00
CRDT- 2012/07/12 06:00
PHST- 2012/07/12 06:00 [entrez]
PHST- 2012/07/12 06:00 [pubmed]
PHST- 2013/03/21 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2012 Apr 3;92(13):882-5.


PMID- 22781525
OWN - NLM
STAT- MEDLINE
DCOM- 20130320
LR  - 20120711
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 92
IP  - 13
DP  - 2012 Apr 3
TI  - [Application of ultrasound guidance for ilioinguinal or iliohypogastric nerve
      block in pediatric inguinal surgery].
PG  - 873-7
AB  - OBJECTIVE: To evaluate the efficacy of ultrasound guidance for ilioinguinal or
      iliohypogastric nerve block in pediatric outpatients undergoing inguinal surgery.
      METHODS: The present study was approved by the ethics committee of our hospital. 
      One hundred children with ASA status I, aged 4 - 8 years old, scheduled for
      unilateral inguinal surgery were randomly divided into ultrasound group (Group U)
      and traditional group (Group T) (n = 50 each). Upon entering operation room, they
      were monitored by electrocardiography (ECG), heart rate (HR) and oxygen
      saturation (SpO(2)). After an induction of general anesthesia, intravenous access
      was established and laryngeal mask inserted with spontaneous breathing.
      Intraoperative anesthesia was maintained with 2% sevoflurane in 50% nitrous oxide
      with 50% oxygen. Children in Group U received an ilioinguinal or iliohypogastric 
      block under ultrasonic guidance with a mixture of 0.8% lidocaine and 0.25%
      levobupivacaine at 0.2 ml/kg while those in Group T performed according to the
      traditional method of anatomical localization with the same local anesthetic at
      0.3 ml/kg. During surgery, the vital signs of HR, respiratory rate (RR), SpO(2), 
      partial pressure of end-tidal carbon dioxide (P(ET)CO(2)) and exhaled sevoflurane
      concentration were recorded. Additional intraoperative analgesic requirements
      were recorded. Face legs activity cry consolability (FLACC) score was used to
      assess the pain score postoperatively at recovery time, 2 and 4 h postoperation
      respectively. If the pain score was above 3, the child received acetaminophen
      rectally. The number of postoperative rectal acetaminophen was recorded. The
      degrees of parental satisfaction were investigated at 2 and 4 h postoperation.
      Intra-or postoperative adverse events were also recorded. RESULTS: HR at skin
      incision and sac traction in Group U was significantly lower than those in Group 
      T (P < 0.05). Six children (12%) needed to increase inhaled sevoflurane
      concentration during operation in Group U versus 17 (34%) in Group T (P < 0.05). 
      The pain score at recovery time, 2 and 4 h postoperation in Group U was
      significantly lower than those in T group (P < 0.05). Only 4 children (8%) needed
      postoperative rectal acetaminophen in Group U versus 13 (26%) in Group T (P <
      0.05). The degree of parental satisfaction at 2 h postoperation was significantly
      higher in Group U than that in Group T (P < 0.05). One case in Group T had needle
      puncturing into blood vessels. No other adverse event was observed in two groups.
      CONCLUSION: The method of ultrasonic guidance for ilioinguinal or iliohypogastric
      nerve block is both feasible and effective. It can not only enhance the effect of
      nerve block, reduce the occurrences of complications, lower the quantity of local
      anesthetic and alleviate the medicinal toxicity.
FAU - Nan, Yang
AU  - Nan Y
AD  - Department of Anesthesiology, Second Affiliated Hospital, Wenzhou Medical
      College, Wenzhou 325027, China.
FAU - Zhou, Jun
AU  - Zhou J
FAU - Ma, Qian
AU  - Ma Q
FAU - Li, Ting
AU  - Li T
FAU - Lian, Qing-quan
AU  - Lian QQ
FAU - Li, Jun
AU  - Li J
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Groin/innervation
MH  - Humans
MH  - Inguinal Canal/innervation
MH  - Male
MH  - Nerve Block/*methods
MH  - *Ultrasonography
EDAT- 2012/07/12 06:00
MHDA- 2013/03/21 06:00
CRDT- 2012/07/12 06:00
PHST- 2012/07/12 06:00 [entrez]
PHST- 2012/07/12 06:00 [pubmed]
PHST- 2013/03/21 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2012 Apr 3;92(13):873-7.


PMID- 22781088
OWN - NLM
STAT- MEDLINE
DCOM- 20130619
LR  - 20211021
IS  - 1476-5438 (Electronic)
IS  - 1018-4813 (Linking)
VI  - 21
IP  - 2
DP  - 2013 Feb
TI  - Personalized medicine and access to health care: potential for inequitable
      access?
PG  - 143-7
LID - 10.1038/ejhg.2012.149 [doi]
AB  - Personalized medicine promises that an individual's genetic information will be
      increasingly used to prioritize access to health care. Use of genetic information
      to inform medical decision making, however, raises questions as to whether such
      use could be inequitable. Using breast cancer genetic risk prediction models as
      an example, on the surface clinical use of genetic information is consistent with
      the tools provided by evidence-based medicine, representing a means to equitably 
      distribute limited health-care resources. However, at present, given limitations 
      inherent to the tools themselves, and the mechanisms surrounding their
      implementation, it becomes clear that reliance on an individual's genetic
      information as part of medical decision making could serve as a vehicle through
      which disparities are perpetuated under public and private health-care delivery
      models. The potential for inequities arising from using genetic information to
      determine access to health care has been rarely discussed. Yet, it raises legal
      and ethical questions distinct from those raised surrounding genetic
      discrimination in employment or access to private insurance. Given the increasing
      role personalized medicine is forecast to play in the provision of health care,
      addressing a broader view of what constitutes genetic discrimination, one that
      occurs along a continuum and includes inequitable access, will be needed during
      the implementation of new applications based on individual genetic profiles. Only
      by anticipating and addressing the potential for inequitable access to health
      care occurring from using genetic information will we move closer to realizing
      the goal of personalized medicine: to improve the health of individuals.
FAU - McClellan, Kelly A
AU  - McClellan KA
AD  - Department of Human Genetics, Centre for Genomics and Policy, Faculty of
      Medicine, McGill University, Montreal, QC, Canada. kelly.mcclellan@mail.mcgill.ca
FAU - Avard, Denise
AU  - Avard D
FAU - Simard, Jacques
AU  - Simard J
FAU - Knoppers, Bartha M
AU  - Knoppers BM
LA  - eng
GR  - CRN-8752-1/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120711
PL  - England
TA  - Eur J Hum Genet
JT  - European journal of human genetics : EJHG
JID - 9302235
SB  - IM
MH  - *Breast Neoplasms/epidemiology
MH  - Delivery of Health Care/ethics/legislation & jurisprudence
MH  - Evidence-Based Medicine
MH  - Female
MH  - *Health Services Accessibility/ethics/legislation & jurisprudence
MH  - Humans
MH  - Precision Medicine/*ethics
PMC - PMC3548263
EDAT- 2012/07/12 06:00
MHDA- 2013/06/20 06:00
CRDT- 2012/07/12 06:00
PHST- 2012/07/12 06:00 [entrez]
PHST- 2012/07/12 06:00 [pubmed]
PHST- 2013/06/20 06:00 [medline]
AID - ejhg2012149 [pii]
AID - 10.1038/ejhg.2012.149 [doi]
PST - ppublish
SO  - Eur J Hum Genet. 2013 Feb;21(2):143-7. doi: 10.1038/ejhg.2012.149. Epub 2012 Jul 
      11.


PMID- 22779422
OWN - NLM
STAT- MEDLINE
DCOM- 20130705
LR  - 20120813
IS  - 1399-0004 (Electronic)
IS  - 0009-9163 (Linking)
VI  - 82
IP  - 3
DP  - 2012 Sep
TI  - Regulating the communication of genetic risk information: the Italian legal
      approach to questions of confidentiality and disclosure.
PG  - 205-9
LID - 10.1111/j.1399-0004.2012.01935.x [doi]
AB  - Communication of genetic risk is a complex process in which the rights of the
      individual and those of relatives may conflict with regard to the information
      revealed by DNA testing. If patients who participate in clinical genetic testing 
      refuse to share their genetic information with at-risk relatives, healthcare
      professionals need to reach a proper ethical balance between the right of
      individual patients regarding the confidentiality of their genetic test result
      and the right of families to be informed about their genetic risk. Rules and
      legislation in most countries generally protect the confidentiality of medical
      information but allow limited disclosure of genetic test results without the
      patient's consent in specific cases when certain conditions are met. The aim of
      this article is to draw attention to how Italian policymakers have attempted to
      balance protection of autonomy and confidentiality, and protection of health by
      means of a hybrid instrument. Furthermore, we show that some of the requirements 
      of that instrument depart from the most widely recognized standards for
      non-consensual disclosure of genetic risk information, while at the same time
      allowing an unusually high level of discretion to healthcare professionals
      involved in genetic counseling and testing.
CI  - (c) 2012 John Wiley & Sons A/S.
FAU - Battistuzzi, L
AU  - Battistuzzi L
AD  - Department of Health Sciences, University of Genoa, Genoa, Italy Clinical
      Genetics Unit, Galliera Hospital, Genoa, Italy. linda.battistuzzi@unige.it
FAU - Ciliberti, R
AU  - Ciliberti R
FAU - Forzano, F
AU  - Forzano F
FAU - De Stefano, F
AU  - De Stefano F
LA  - eng
PT  - Journal Article
DEP - 20120727
PL  - Denmark
TA  - Clin Genet
JT  - Clinical genetics
JID - 0253664
SB  - IM
MH  - Communication
MH  - Confidentiality/*ethics
MH  - Disclosure/*ethics
MH  - Genetic Testing/ethics
MH  - Health Policy
MH  - Humans
MH  - Informed Consent/*ethics/legislation & jurisprudence
MH  - Italy
MH  - Risk Assessment
EDAT- 2012/07/12 06:00
MHDA- 2013/07/06 06:00
CRDT- 2012/07/12 06:00
PHST- 2012/07/12 06:00 [entrez]
PHST- 2012/07/12 06:00 [pubmed]
PHST- 2013/07/06 06:00 [medline]
AID - 10.1111/j.1399-0004.2012.01935.x [doi]
PST - ppublish
SO  - Clin Genet. 2012 Sep;82(3):205-9. doi: 10.1111/j.1399-0004.2012.01935.x. Epub
      2012 Jul 27.


PMID- 22778792
OWN - NLM
STAT- MEDLINE
DCOM- 20121212
LR  - 20211021
IS  - 1866-0452 (Electronic)
IS  - 1866-0452 (Linking)
VI  - 109
IP  - 22-23
DP  - 2012 Jun
TI  - Decision aids for patients.
PG  - 401-8
LID - 10.3238/arztebl.2012.0401 [doi]
AB  - BACKGROUND: Patients want to be more involved in medical decision-making. To this
      end, some decision aids are now available. METHODS: We present an overview of
      this subject, in which we explain the terms "shared decision-making", "decision
      aid", and "evidence-based patient information" and survey information on the
      available decision aids in German and other languages on the basis of a
      literature search in MEDLINE, EMBASE and PsycInfo and a current Cochrane Review. 
      We also searched the Internet for providers of decision aids in Germany. RESULTS:
      Decision aids exist in the form of brochures, decision tables, videos, and
      computer programs; they address various topics in the prevention, diagnosis, and 
      treatment of disease. They typically contain information on the advantages and
      disadvantages of the available options, as well as guidance for personal
      decision-making. They can be used alone or as a part of structured counseling or 
      patient education. Minimal quality standards include an adequate evidence base,
      completeness, absence of bias, and intelligibility. Our search revealed 12
      randomized controlled trials (RCTs) of decision aids in German and 106 RCTs of
      decision aids in other languages. These trials studied the outcome of the use of 
      decision aids not just with respect to clinical developments, but also with
      respect to patient knowledge, adherence to treatment regimens, satisfaction,
      involvement in decision-making, autonomy preference, and decisional conflicts.
      CONCLUSION: Only a small fraction of the available decision aids were
      systematically developed and have been subjected to systematic evaluation.
      Patients are still not receiving the help in decision-making to which medical
      ethics entitles them. Structures need to be put in place for the sustainable
      development, evaluation and implementation of high-quality decision aids.
FAU - Lenz, Matthias
AU  - Lenz M
AD  - Hamburg University, School of Mathematics, Informatics and Natural Sciences,
      Hamburg, Germany. matthias.lenz@uni-hamburg.de
FAU - Buhse, Susanne
AU  - Buhse S
FAU - Kasper, Jurgen
AU  - Kasper J
FAU - Kupfer, Ramona
AU  - Kupfer R
FAU - Richter, Tanja
AU  - Richter T
FAU - Muhlhauser, Ingrid
AU  - Muhlhauser I
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120604
PL  - Germany
TA  - Dtsch Arztebl Int
JT  - Deutsches Arzteblatt international
JID - 101475967
SB  - IM
CIN - Dtsch Arztebl Int. 2012 Nov;109(46):802; author reply 802. PMID: 23264829
MH  - Audiovisual Aids/*trends
MH  - Computer-Assisted Instruction/*trends
MH  - *Decision Making, Computer-Assisted
MH  - Germany
MH  - Humans
MH  - Information Dissemination/*methods
MH  - *Informed Consent
MH  - Patient Education as Topic/*trends
MH  - Patient Participation/*trends
PMC - PMC3389744
EDAT- 2012/07/11 06:00
MHDA- 2012/12/13 06:00
CRDT- 2012/07/11 06:00
PHST- 2011/10/24 00:00 [received]
PHST- 2012/01/16 00:00 [accepted]
PHST- 2012/07/11 06:00 [entrez]
PHST- 2012/07/11 06:00 [pubmed]
PHST- 2012/12/13 06:00 [medline]
AID - 10.3238/arztebl.2012.0401 [doi]
PST - ppublish
SO  - Dtsch Arztebl Int. 2012 Jun;109(22-23):401-8. doi: 10.3238/arztebl.2012.0401.
      Epub 2012 Jun 4.


PMID- 22778672
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120910
LR  - 20211021
IS  - 1524-5012 (Print)
IS  - 1524-5012 (Linking)
VI  - 12
IP  - 2
DP  - 2012 Summer
TI  - Bioethics in practice: a quarterly column about medical ethics - assessment of
      patients' capacity to make medical decisions.
PG  - 92-3
FAU - Blais, Christopher M
AU  - Blais CM
AD  - Department of Palliative Medicine, Ochsner Clinic Foundation, New Orleans, LA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ochsner J
JT  - The Ochsner journal
JID - 101125795
PMC - PMC3387852
EDAT- 2012/07/11 06:00
MHDA- 2012/07/11 06:01
CRDT- 2012/07/11 06:00
PHST- 2012/07/11 06:00 [entrez]
PHST- 2012/07/11 06:00 [pubmed]
PHST- 2012/07/11 06:01 [medline]
PST - ppublish
SO  - Ochsner J. 2012 Summer;12(2):92-3.


PMID- 22778541
OWN - NLM
STAT- MEDLINE
DCOM- 20121127
LR  - 20220321
IS  - 1087-2981 (Electronic)
IS  - 1087-2981 (Linking)
VI  - 17
DP  - 2012
TI  - Design, implementation and evaluation of a community health training program in
      an integrated problem-based medical curriculum: a fifteen-year experience at the 
      University of Geneva Faculty of Medicine.
PG  - 16741
LID - 10.3402/meo.v17i0.16741 [doi]
AB  - BACKGROUND: In the literature the need for relevance in medical education and
      training has been stressed. In the last 40 years medical schools have been
      challenged to train doctors competent to respond to community health needs. In
      the mid-90s the University of Geneva Faculty of Medicine introduced an integrated
      medical curriculum. In this initiative a particular emphasis was put in
      introducing a 6-year longitudinal and multidisciplinary Community Health Program 
      (CHP). OBJECTIVES: The aims of the present article are to describe the
      conception, elaboration and implementation of the CHP as well as its evolution
      over 15 years and the evaluation of its outcomes. METHODS: The CHP was at its
      origin elaborated by a small group of highly motivated teachers and later on
      developed by a multi-disciplinary group of primary care physicians,
      epidemiologists, public health and bio-ethics specialists, occupational health
      professionals, lawyers and historians. Evaluation of the program outcomes
      included educational innovations, new developments of the curriculum and
      interactions between students and the community. RESULTS: The CHP learning
      objectives and teaching modalities were defined by the multi-disciplinary group
      in consensus meetings which triggered a collaborative spirit among teachers and
      facilitated further developments. The evaluation procedures allowed the
      monitoring of students' satisfaction which remained high over the years,
      students' active participation which decreased over time and success at
      certifying exams which was globally as good as in basic life sciences. The
      evaluation also assessed outcomes such as educational innovations, new
      developments of the curriculum and interactions between students and the
      community. CONCLUSION: As suggested in the literature, our experience shows that 
      the students' direct exposure and practice in the community health environment is
      an effective training approach to broaden students' education by offering them a 
      community perspective of health and disease.
FAU - Chastonay, Philippe
AU  - Chastonay P
AD  - Unit of Development and Research in Medical Education, University of Geneva
      Faculty of Medicine and Geneva University Hospital, Geneva, Switzerland.
FAU - Vu, Nu Viet
AU  - Vu NV
FAU - Humair, Jean-Paul
AU  - Humair JP
FAU - Mpinga, Emmanuel Kabengele
AU  - Mpinga EK
FAU - Bernheim, Laurent
AU  - Bernheim L
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20120629
PL  - United States
TA  - Med Educ Online
JT  - Medical education online
JID - 9806550
SB  - IM
MH  - Community Health Services
MH  - *Curriculum
MH  - *Education, Medical
MH  - Humans
MH  - Problem-Based Learning/*organization & administration
MH  - *Program Development
MH  - *Program Evaluation
MH  - Public Health/*education
MH  - Surveys and Questionnaires
MH  - Switzerland
MH  - *Systems Integration
PMC - PMC3387672
OTO - NOTNLM
OT  - community health
OT  - community-based learning
OT  - curriculum reform
OT  - medical curriculum
OT  - problem-based learning
EDAT- 2012/07/11 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/11 06:00
PHST- 2011/12/25 00:00 [received]
PHST- 2012/05/14 00:00 [revised]
PHST- 2012/05/17 00:00 [accepted]
PHST- 2012/07/11 06:00 [entrez]
PHST- 2012/07/11 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.3402/meo.v17i0.16741 [doi]
AID - MEO-17-16741 [pii]
PST - ppublish
SO  - Med Educ Online. 2012;17:16741. doi: 10.3402/meo.v17i0.16741. Epub 2012 Jun 29.


PMID- 22778528
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20220331
IS  - 2374-250X (Electronic)
IS  - 1042-5055 (Linking)
VI  - 26
IP  - 1
DP  - 2012 Spring
TI  - Interprofessional collaboration and turf wars how prevalent are hidden attitudes?
PG  - 32-9
AB  - PURPOSE: Interprofessional collaboration in health care is believed to enhance
      patient outcomes. However, where professions have overlapping scopes of practice 
      (eg, chiropractors and physical therapists), "turf wars" can hinder effective
      collaboration. Deep-rooted beliefs, identified as implicit attitudes, provide a
      potential explanation. Even with positive explicit attitudes toward a social
      group, negative stereotypes may be influential. Previous studies on
      interprofessional attitudes have mostly used qualitative research methodologies. 
      This study used quantitative methods to evaluate explicit and implicit attitudes 
      of physical therapy students toward chiropractic. METHODS: A paper-and-pencil
      instrument was developed and administered to 49 individuals (students and
      faculty) associated with a Canadian University master's entry-level physical
      therapy program after approval by the Research Ethics Board. The instrument
      evaluated explicit and implicit attitudes toward the chiropractic profession.
      Implicit attitudes were determined by comparing response times of chiropractic
      paired with positive versus negative descriptors. RESULTS: Mean time to complete 
      a word association task was significantly longer (t = 4.75, p =.00) when
      chiropractic was associated with positive rather than negative words. Explicit
      and implicit attitudes were not correlated (r = 0.13, p =.38). CONCLUSIONS: While
      little explicit bias existed, individuals associated with a master's entry-level 
      physical therapy program appeared to have a significant negative implicit bias
      toward chiropractic.
FAU - Chung, Chadwick L R
AU  - Chung CL
AD  - Canadian Memorial Chiropractic College.
FAU - Manga, Jasmin
AU  - Manga J
FAU - McGregor, Marion
AU  - McGregor M
FAU - Michailidis, Christos
AU  - Michailidis C
FAU - Stavros, Demetrios
AU  - Stavros D
FAU - Woodhouse, Linda J
AU  - Woodhouse LJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Chiropr Educ
JT  - The Journal of chiropractic education
JID - 8915779
PMC - PMC3391774
OTO - NOTNLM
OT  - Attitude
OT  - Chiropractic
OT  - Education
OT  - Interprofessional Relations
OT  - Physical Therapy
EDAT- 2012/07/11 06:00
MHDA- 2012/07/11 06:01
CRDT- 2012/07/11 06:00
PHST- 2011/03/29 00:00 [received]
PHST- 2011/07/05 00:00 [revised]
PHST- 2011/07/20 00:00 [revised]
PHST- 2011/07/23 00:00 [accepted]
PHST- 2012/07/11 06:00 [entrez]
PHST- 2012/07/11 06:00 [pubmed]
PHST- 2012/07/11 06:01 [medline]
PST - ppublish
SO  - J Chiropr Educ. 2012 Spring;26(1):32-9.


PMID- 22778343
OWN - NLM
STAT- MEDLINE
DCOM- 20121210
LR  - 20211021
IS  - 1544-5208 (Electronic)
IS  - 0278-2715 (Linking)
VI  - 31
IP  - 7
DP  - 2012 Jul
TI  - Given financial constraints, it would be unethical to divert antiretroviral drugs
      from treatment to prevention.
PG  - 1537-44
LID - 10.1377/hlthaff.2012.0071 [doi]
AB  - Striking advances in HIV prevention have set the stage for renewed debate on
      setting priorities in the fight against HIV/AIDS. Two new prevention
      strategies--preexposure prophylaxis and treatment as prevention--use
      antiretroviral drugs for prevention of HIV/AIDS in addition to treating patients.
      The potential for success of these new prevention strategies sets up an ethical
      dilemma: where resources are limited and supplies of lifesaving antiretroviral
      medications are insufficient to treat those currently living with HIV, how should
      these resources be divided between treatment and prevention? This article
      explores several ethical principles used in formulating public health policy.
      Assuming that limited resources are available for spending on drugs, we conclude 
      that it would be unethical to watch patients with treatable AIDS worsen and die, 
      even with supportive care, so that medications for treatment can be diverted for 
      prevention.
FAU - Macklin, Ruth
AU  - Macklin R
AD  - Department of Epidemiology and Population Health, Albert Einstein College of
      Medicine, Bronx, NY, USA. ruth.macklin@einstein.yu.edu
FAU - Cowan, Ethan
AU  - Cowan E
LA  - eng
GR  - K23 AI078755/AI/NIAID NIH HHS/United States
GR  - 5 K23 AI078755-04/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Health Aff (Millwood)
JT  - Health affairs (Project Hope)
JID - 8303128
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - Anti-HIV Agents/economics/*therapeutic use
MH  - Drug Costs/statistics & numerical data
MH  - *Ethics, Medical
MH  - HIV Infections/drug therapy/*prevention & control
MH  - Health Expenditures/statistics & numerical data
MH  - Health Policy
MH  - Health Priorities/economics
MH  - Humans
MH  - Resource Allocation/economics
PMC - PMC3572856
MID - NIHMS440599
EDAT- 2012/07/11 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/07/11 06:00
PHST- 2012/07/11 06:00 [entrez]
PHST- 2012/07/11 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - 31/7/1537 [pii]
AID - 10.1377/hlthaff.2012.0071 [doi]
PST - ppublish
SO  - Health Aff (Millwood). 2012 Jul;31(7):1537-44. doi: 10.1377/hlthaff.2012.0071.


PMID- 22778303
OWN - NLM
STAT- MEDLINE
DCOM- 20121011
LR  - 20211021
IS  - 1098-4275 (Electronic)
IS  - 0031-4005 (Linking)
VI  - 130
IP  - 2
DP  - 2012 Aug
TI  - Choriophobia: a 1-act play.
PG  - 342-6
LID - 10.1542/peds.2012-0106 [doi]
AB  - The management of a newborn born to a mother with chorioamnionitis is
      controversial. By using data collected on neonates born in the era of routine
      maternal screening for Group B Streptococcus, we calculate that the risk of
      early-onset sepsis in a hypothetical infant born at term to a mother with
      chorioamnionitis, who has a normal physical examination at birth, is likely
      substantially <1% if the mother's screen for Group B Streptococcus was negative. 
      This low rate of sepsis calls into question current guidelines recommending
      treatment of all such newborns with intravenous antibiotics for 48 hours pending 
      the results of a blood culture. Current guidelines for the management of infants 
      born to mothers with chorioamnionitis also raise an important ethical issue; the 
      recommendation to treat these infants with intravenous antibiotics is, in
      essence, a de facto determination of what constitutes unacceptable risk to the
      newborn. We argue that this determination is ultimately value-based and therefore
      requires broader deliberation than that which frequently occurs among medical
      experts who develop medical guidelines.
FAU - Taylor, James A
AU  - Taylor JA
AD  - Department of Pediatrics, University of Washington, Box 354920, Seattle, WA
      98195-4920, USA. uncjat@u.washington.edu
FAU - Opel, Douglas J
AU  - Opel DJ
LA  - eng
GR  - K23 HD069467/HD/NICHD NIH HHS/United States
PT  - Journal Article
DEP - 20120709
PL  - United States
TA  - Pediatrics
JT  - Pediatrics
JID - 0376422
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Academic Medical Centers
MH  - Adult
MH  - Anti-Bacterial Agents/therapeutic use
MH  - Chorioamnionitis/*diagnosis/*drug therapy
MH  - Cooperative Behavior
MH  - Ethics, Medical
MH  - Female
MH  - Guideline Adherence/ethics
MH  - Humans
MH  - Infant, Newborn
MH  - Infusions, Intravenous/ethics
MH  - Interdisciplinary Communication
MH  - Internship and Residency
MH  - Medical Staff, Hospital
MH  - Pregnancy
MH  - Sepsis/diagnosis/drug therapy
MH  - Streptococcal Infections/*diagnosis/*drug therapy
MH  - *Streptococcus agalactiae
MH  - Unnecessary Procedures/ethics
PMC - PMC8194452
EDAT- 2012/07/11 06:00
MHDA- 2012/10/12 06:00
CRDT- 2012/07/11 06:00
PHST- 2012/07/11 06:00 [entrez]
PHST- 2012/07/11 06:00 [pubmed]
PHST- 2012/10/12 06:00 [medline]
AID - peds.2012-0106 [pii]
AID - 10.1542/peds.2012-0106 [doi]
PST - ppublish
SO  - Pediatrics. 2012 Aug;130(2):342-6. doi: 10.1542/peds.2012-0106. Epub 2012 Jul 9.


PMID- 22777976
OWN - NLM
STAT- MEDLINE
DCOM- 20120823
LR  - 20120710
IS  - 0093-0334 (Print)
IS  - 0093-0334 (Linking)
VI  - 42
IP  - 4
DP  - 2012 Jul-Aug
TI  - The ethics of vaginal birth after cesarean.
PG  - 24-7
LID - 10.1002/hast.52 [doi]
FAU - Charles, Sonya
AU  - Charles S
LA  - eng
PT  - Journal Article
DEP - 20120615
PL  - United States
TA  - Hastings Cent Rep
JT  - The Hastings Center report
JID - 0410447
SB  - IM
MH  - Beneficence
MH  - Female
MH  - Guideline Adherence/*ethics
MH  - Health Services Accessibility/*ethics
MH  - Humans
MH  - Obstetrics/ethics
MH  - Patient Rights/*ethics
MH  - Personal Autonomy
MH  - Physician's Role
MH  - *Practice Guidelines as Topic
MH  - Pregnancy
MH  - United States
MH  - Vaginal Birth after Cesarean/*ethics
EDAT- 2012/07/11 06:00
MHDA- 2012/08/24 06:00
CRDT- 2012/07/11 06:00
PHST- 2012/07/11 06:00 [entrez]
PHST- 2012/07/11 06:00 [pubmed]
PHST- 2012/08/24 06:00 [medline]
AID - 10.1002/hast.52 [doi]
PST - ppublish
SO  - Hastings Cent Rep. 2012 Jul-Aug;42(4):24-7. doi: 10.1002/hast.52. Epub 2012 Jun
      15.


PMID- 22777654
OWN - NLM
STAT- MEDLINE
DCOM- 20130318
LR  - 20150813
IS  - 1740-7753 (Electronic)
IS  - 1740-7745 (Linking)
VI  - 9
IP  - 5
DP  - 2012 Oct
TI  - Clinical equipoise and risk-benefit assessment.
PG  - 621-7
LID - 10.1177/1740774512450952 [doi]
AB  - Clinical equipoise is widely regarded as an ethical requirement for the design
      and conduct of randomized controlled trials (RCTs). Underlying clinical equipoise
      is the norm that no patient should be randomized to treatment known (or believed 
      by the expert clinical community) to be inferior to the established standard of
      care. This implies that patient-subjects should not be exposed to net risks in
      control groups of randomized trials - risks that are not compensated by the
      prospect of direct medical benefits from the control intervention. However,
      proponents of clinical equipoise have no moral objections to permitting net risks
      for 'nontherapeutic' research procedures employed in clinical trials. This
      differential assessment makes risk-benefit assessment of randomized trials
      incoherent. In this article, I examine critically four arguments in defense of
      clinical equipoise as a requirement for risk-benefit assessment. Each of these
      arguments fails to support clinical equipoise, leading to the conclusion that we 
      should dispense with this principle in risk-benefit assessment of RCTs.
FAU - Miller, Franklin G
AU  - Miller FG
AD  - Department of Bioethics, National Institutes of Health, Bethesda, MD 20892-1156, 
      USA. fmiller@nih.gov
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
DEP - 20120709
PL  - England
TA  - Clin Trials
JT  - Clinical trials (London, England)
JID - 101197451
SB  - IM
CIN - Clin Trials. 2012 Oct;9(5):628-9. PMID: 23060320
CIN - Clin Trials. 2012 Oct;9(5):630-1. PMID: 23060321
MH  - Humans
MH  - Nontherapeutic Human Experimentation/*ethics
MH  - Randomized Controlled Trials as Topic/*ethics
MH  - Risk Assessment
MH  - *Therapeutic Equipoise
EDAT- 2012/07/11 06:00
MHDA- 2013/03/19 06:00
CRDT- 2012/07/11 06:00
PHST- 2012/07/11 06:00 [entrez]
PHST- 2012/07/11 06:00 [pubmed]
PHST- 2013/03/19 06:00 [medline]
AID - 1740774512450952 [pii]
AID - 10.1177/1740774512450952 [doi]
PST - ppublish
SO  - Clin Trials. 2012 Oct;9(5):621-7. doi: 10.1177/1740774512450952. Epub 2012 Jul 9.


PMID- 22777055
OWN - NLM
STAT- MEDLINE
DCOM- 20130103
LR  - 20220317
IS  - 1873-4626 (Electronic)
IS  - 1091-255X (Linking)
VI  - 16
IP  - 9
DP  - 2012 Sep
TI  - Methodological and ethical quality of randomized controlled clinical trials in
      gastrointestinal surgery.
PG  - 1758-67
LID - 10.1007/s11605-012-1952-0 [doi]
AB  - BACKGROUND: The randomized controlled trial (RCT) is the gold standard tool used 
      to evaluate therapeutic interventions. Methodological and ethical aspects should 
      be adequately reported to enable readers to make informed and justified judgments
      regarding the validity of a trial and the treatment effectiveness. OBJECTIVE: The
      aim of this study was to evaluate the methodological and ethical qualities of
      randomized clinical trials in gastrointestinal surgery and to assess the
      relationship between these two qualities. STUDY DESIGN: All of the articles
      chosen for review reported on phase III randomized controlled gastrointestinal
      surgical trials were published in 12 international journals during 2006 and 2007.
      The eligible studies were identified, selected, and then evaluated based on a
      broad set of predetermined criteria. The methodological quality was evaluated
      using the Jadad scale, and the ethical quality was evaluated using the Berdeu
      score. RESULTS: The mean Jadad score was 9.7 +/- 1.78. The methodological quality
      was insufficient in 64 RCTs (37.4 %; Jadad score <9). The mean Berdeu score was
      0.36 +/- 0.08. The journal impact factor, number of randomized patients, and
      number of centers correlated with the outcome of the Jadad score, and the journal
      impact factor, industry funding, and year in which the trial began correlated
      with the outcome of the Berdeu score. Informed consent from patients was not
      obtained in 7 % (n = 12) of the RCTs, and research ethics committee approval was 
      not mentioned in 14.6 % (n = 25) of the RCTs. CONCLUSIONS: The reporting of
      gastrointestinal surgery RCTs is less than optimal. In our study, the trials of
      higher methodological quality were more likely to provide information about their
      ethical aspects. These results suggest the need for more attention to be paid to 
      the conduct of clinical research and the reporting of ethical aspects. The
      appropriation of the ethical rules by surgeons involved in human clinical trials 
      could improve the methodology and reporting of RCTs in gastrointestinal surgery.
FAU - Bridoux, Valerie
AU  - Bridoux V
AD  - Department of Digestive Surgery, Rouen University Hospital, 1 rue Germont, 76031 
      Rouen Cedex, France.
FAU - Moutel, Gregoire
AU  - Moutel G
FAU - Roman, Horace
AU  - Roman H
FAU - Kianifard, Babak
AU  - Kianifard B
FAU - Michot, Francis
AU  - Michot F
FAU - Herve, Christian
AU  - Herve C
FAU - Tuech, Jean-Jacques
AU  - Tuech JJ
LA  - eng
PT  - Journal Article
DEP - 20120710
PL  - United States
TA  - J Gastrointest Surg
JT  - Journal of gastrointestinal surgery : official journal of the Society for Surgery
      of the Alimentary Tract
JID - 9706084
SB  - IM
MH  - Clinical Trials, Phase III as Topic/*ethics/*methods/standards
MH  - Digestive System Surgical Procedures
MH  - Humans
MH  - Journal Impact Factor
MH  - Periodicals as Topic
MH  - Randomized Controlled Trials as Topic/*ethics/*methods/standards
EDAT- 2012/07/11 06:00
MHDA- 2013/01/04 06:00
CRDT- 2012/07/11 06:00
PHST- 2012/03/25 00:00 [received]
PHST- 2012/06/24 00:00 [accepted]
PHST- 2012/07/11 06:00 [entrez]
PHST- 2012/07/11 06:00 [pubmed]
PHST- 2013/01/04 06:00 [medline]
AID - 10.1007/s11605-012-1952-0 [doi]
PST - ppublish
SO  - J Gastrointest Surg. 2012 Sep;16(9):1758-67. doi: 10.1007/s11605-012-1952-0. Epub
      2012 Jul 10.


PMID- 22776580
OWN - NLM
STAT- MEDLINE
DCOM- 20121121
LR  - 20141120
IS  - 1541-3772 (Electronic)
IS  - 1048-2911 (Linking)
VI  - 22
IP  - 2
DP  - 2012
TI  - A collaborative effort to address the distribution of plutonium-contaminated
      sludge in Livermore, California.
PG  - 191-211
LID - 10.2190/NS.22.2.f [doi]
AB  - Plutonium releases from the U.S. nuclear weapons laboratory in Livermore,
      California resulted in the contamination of sewage sludge. Two research models to
      address the potential public health impacts of plutonium-contaminated sludge
      distribution were undertaken. One model was a collaborative approach that
      emphasized incorporating local knowledge into the scientific analysis and
      fostering the growth of mutually respectful relationships between scientists,
      governmental, and non-governmental collaborators. The second was a
      dose-assessment approach that utilized existing data to estimate radiological
      doses from exposure to plutonium contaminated sewage sludge and compared the
      estimated doses with those that have caused sickness or death. The two models
      reached different conclusions; neither addressed issues of intergenerational
      equity and primary prevention of exposure. Advancing an ethical research agenda
      will involve looking upstream of the contamination and working toward sustainable
      solutions to security that do not involve the public health threats embedded in
      the global embrace of nuclear weapons.
FAU - Sutton, Patrice
AU  - Sutton P
AD  - UCSF Program on Reproductive Health and the Environment, Oakland, CA 94612, USA.
FAU - Cabasso, Jacqueline
AU  - Cabasso J
FAU - Barreau, Tracy
AU  - Barreau T
FAU - Kelley, Marylia
AU  - Kelley M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - New Solut
JT  - New solutions : a journal of environmental and occupational health policy : NS
JID - 9100937
RN  - 0 (Radioactive Pollutants)
RN  - 0 (Sewage)
RN  - 53023GN24M (Plutonium)
SB  - IM
MH  - California
MH  - *Community-Institutional Relations
MH  - *Cooperative Behavior
MH  - Environmental Exposure/statistics & numerical data
MH  - Environmental Restoration and Remediation
MH  - Ethics, Research
MH  - Humans
MH  - Plutonium/*analysis/toxicity
MH  - Radiation Dosage
MH  - Radiation Monitoring/methods
MH  - Radioactive Pollutants/*analysis/toxicity
MH  - Research Design
MH  - Sewage/adverse effects/*chemistry
EDAT- 2012/07/11 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/11 06:00
PHST- 2012/07/11 06:00 [entrez]
PHST- 2012/07/11 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - G532817658105337 [pii]
AID - 10.2190/NS.22.2.f [doi]
PST - ppublish
SO  - New Solut. 2012;22(2):191-211. doi: 10.2190/NS.22.2.f.


PMID- 22776403
OWN - NLM
STAT- MEDLINE
DCOM- 20121025
LR  - 20120710
IS  - 0870-2551 (Print)
IS  - 0870-2551 (Linking)
VI  - 31
IP  - 7-8
DP  - 2012 Jul-Aug
TI  - Relations between professional medical associations and healthcare industry,
      concerning scientific communication and continuing medical education: a policy
      statement from the European Society of Cardiology.
PG  - 529-38
LID - 10.1016/j.repc.2012.06.007 [doi]
AB  - Physicians have an ethical duty to keep up-to-date with current knowledge.
      Professional medical associations such as the European Society of Cardiology
      (ESC) support these obligations. In Europe, the costs of continuing medical
      education (CME) are insufficiently supported from governments and employers;
      however, medical associations have been criticized for accepting alternative
      financial support from industry. Medical education and training in research
      include learning how to assess the quality and reliability of any information.
      There is some risk of bias in any form of scientific communication including
      intellectual, professional, and financial and it is essential that in particular,
      the latter must be acknowledged by full disclosure. It is essential that there is
      strong collaboration between basic and clinical researchers from academic
      institutions on the one hand, with engineers and scientists from the research
      divisions of device and pharmaceutical companies on the other. This is vital so
      that new diagnostic methods and treatments are developed. Promotion of advances
      by industry may accelerate their implementation into clinical practice.
      Universities now frequently exhort their academic staff to protect their
      intellectual property or commercialize their research. Thus, it is not commercial
      activity or links per se that have become the target for criticism but the
      perceived influence of commercial enterprises on clinical decision-making or on
      messages conveyed by professional medical organizations. This document offers the
      perspective of the ESC on the current debate, and it recommends how to minimize
      bias in scientific communications and CME and how to ensure proper ethical
      standards and transparency in relations between the medical profession and
      industry.
CI  - Copyright (c) 2012. Published by Elsevier Espana.
CN  - ESC Board
LA  - eng
PT  - Guideline
PT  - Journal Article
PL  - Portugal
TA  - Rev Port Cardiol
JT  - Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de
      Cardiologia = Portuguese journal of cardiology : an official journal of the
      Portuguese Society of Cardiology
JID - 8710716
SB  - IM
MH  - *Communication
MH  - Education, Medical, Continuing/*standards
MH  - Europe
MH  - *Health Care Sector
MH  - Humans
MH  - *Interprofessional Relations
IR  - Komajda M
FIR - Komajda, Michel
IR  - Ferrari R
FIR - Ferrari, Roberto
IR  - Vardas P
FIR - Vardas, Pangiotis
IR  - Pinto FJ
FIR - Pinto, Fausto Jose
IR  - Swahn E
FIR - Swahn, Eva
IR  - Torbicki A
FIR - Torbicki, Adam
IR  - Wood DA
FIR - Wood, David Allan
IR  - Bugiardini R
FIR - Bugiardini, Raffaele
IR  - Derumeaux GA
FIR - Derumeaux, Genevieve Anne
IR  - Kautzner J
FIR - Kautzner, Josef
IR  - Pierard L
FIR - Pierard, Luc
IR  - Borggrefe M
FIR - Borggrefe, Martin
IR  - Degertekin M
FIR - Degertekin, Muzaffer
IR  - Boehm M
FIR - Boehm, Michael
IR  - Smiseth O
FIR - Smiseth, Otto
IR  - Bax J
FIR - Bax, Jeroen
IR  - Lueschner TF
FIR - Lueschner, Thomas Felix
IR  - Van de Werf F
FIR - Van de Werf, Frans
IR  - Deaton C
FIR - Deaton, Christi
IR  - Tavazzi L
FIR - Tavazzi, Luigi
IR  - Huber K
FIR - Huber, Kurt
IR  - Ponikowski P
FIR - Ponikowski, Piotr
IR  - Badano LP
FIR - Badano, Luigi Paolo
IR  - Fajadet J
FIR - Fajadet, Jean
IR  - Giannuzzi P
FIR - Giannuzzi, Pantaleo
IR  - Auricchio A
FIR - Auricchio, Angelo
IR  - Bardinet I
FIR - Bardinet, Isabel
IR  - Fraser AG
FIR - Fraser, Alan G
EDAT- 2012/07/11 06:00
MHDA- 2012/10/26 06:00
CRDT- 2012/07/11 06:00
PHST- 2012/05/23 00:00 [received]
PHST- 2012/05/23 00:00 [accepted]
PHST- 2012/07/11 06:00 [entrez]
PHST- 2012/07/11 06:00 [pubmed]
PHST- 2012/10/26 06:00 [medline]
AID - S0870-2551(12)00163-1 [pii]
AID - 10.1016/j.repc.2012.06.007 [doi]
PST - ppublish
SO  - Rev Port Cardiol. 2012 Jul-Aug;31(7-8):529-38. doi: 10.1016/j.repc.2012.06.007.


PMID- 22776311
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20211021
IS  - 1873-5223 (Electronic)
IS  - 1471-5953 (Linking)
VI  - 12
IP  - 5
DP  - 2012 Sep
TI  - An evaluation of the effectiveness of information literacy training for
      undergraduate midwives to improve their ability to access evidence for practice.
PG  - 269-72
LID - 10.1016/j.nepr.2012.06.005 [doi]
AB  - BACKGROUND: Several authors have suggested that computer skills should be taught 
      within the undergraduate curriculum. In this paper, the focus is mainly on the
      results of an examination of midwifery students' search strategy in response to a
      specific question undertaken before and after training session in the first,
      second and third years of the undergraduate programme. METHODS: The intervention 
      allocated 16 h of library-based instruction over the first three years of the
      programme focussing specifically on the skills required to utilise electronic
      resources effectively. Following ethical approval by the university, 108
      undergraduates took part from 2008 to 2011. RESULTS: The data obtained from the
      search history files were categorised as either poor, fair or good. The primary
      analyses compared the pre and post-instruction categories in each year, within
      each student, with a comparison of each student's post-instruction category one
      year and the pre-instruction category the following year. The data indicated that
      the sessions in the first and second years of the programmes resulted in
      improvements in the ability to search, with less improvement in third year.
      CONCLUSIONS: As with any complex intervention, it is not possible to tease out
      which elements of the session were most beneficial. We will try to identify ways 
      in which midwifery students' search skills could be strengthened further.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Lalor, Joan G
AU  - Lalor JG
AD  - School of Nursing and Midwifery, Trinity College Dublin, 24 D'Olier Street,
      Dublin 2, Ireland. j.lalor@tcd.ie
FAU - Clarke, Michael
AU  - Clarke M
FAU - Sheaf, Greg
AU  - Sheaf G
LA  - eng
GR  - G0901530/MRC_/Medical Research Council/United Kingdom
PT  - Evaluation Study
PT  - Journal Article
DEP - 20120707
PL  - Scotland
TA  - Nurse Educ Pract
JT  - Nurse education in practice
JID - 101090848
SB  - IM
MH  - Education, Nursing, Baccalaureate/*organization & administration
MH  - Educational Measurement/*statistics & numerical data
MH  - *Evidence-Based Nursing
MH  - Female
MH  - Humans
MH  - *Information Literacy
MH  - Midwifery/*education
MH  - Nursing Education Research
MH  - Nursing Evaluation Research
MH  - Pregnancy
MH  - Time Factors
EDAT- 2012/07/11 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/11 06:00
PHST- 2011/11/14 00:00 [received]
PHST- 2012/05/15 00:00 [revised]
PHST- 2012/06/06 00:00 [accepted]
PHST- 2012/07/11 06:00 [entrez]
PHST- 2012/07/11 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - S1471-5953(12)00115-1 [pii]
AID - 10.1016/j.nepr.2012.06.005 [doi]
PST - ppublish
SO  - Nurse Educ Pract. 2012 Sep;12(5):269-72. doi: 10.1016/j.nepr.2012.06.005. Epub
      2012 Jul 7.


PMID- 22776288
OWN - NLM
STAT- MEDLINE
DCOM- 20130319
LR  - 20121010
IS  - 1463-1318 (Electronic)
IS  - 1462-8910 (Linking)
VI  - 14
IP  - 11
DP  - 2012 Nov
TI  - Single-incision right hemicolectomy for malignancy: a feasible technique with
      standard laparoscopic instrumentation.
PG  - e764-70
LID - 10.1111/j.1463-1318.2012.03175.x [doi]
AB  - AIM: Single-incision laparoscopy is a rapidly evolving technique in the spectrum 
      'standard laparoscopy-natural orifice transluminal endoscopic surgery (NOTES)'.
      From a commercial perspective, purchase of articulating instruments is advised.
      However, here we present our early experience with single-incision laparoscopy
      for right hemicolectomy with standard laparoscopic instrumentation. METHOD:
      Between June 2010 and December 2011, 25 patients presenting with malignant
      disease underwent single-incision laparoscopy for right hemicolectomy. Four
      different ports (SILS port, Covidien; SSL((R)) Access system, Ethicon;
      X-Cone/S-Portal((R)) , Storz; and OCTO port, AFS Medical) were used. Patients
      were recruited prospectively and all data were processed retrospectively.
      RESULTS: Twenty-five patients were included in our study (and their
      characteristics, described later in this paragraph, are expressed as median
      (range)). Four conversions to standard laparoscopy were performed. The age of
      patients was 69 (36-89) years, and they had a body mass index (BMI) of 24.5
      (19.1-34.2). The duration of surgery was 110 (70-148) min with a healed skin
      incision length of 35 (20-60) mm. Hospital stay was 5 (2-15) days. In four
      patients discharge was delayed because of comorbidity. One patient suffered an
      overwhelming pneumonia. CONCLUSION: Single-incision laparoscopy using standard
      laparoscopic instruments appears to be a safe and feasible technique for
      malignant disease requiring right hemicolectomy. Randomized, prospective trials
      are ongoing to prove the benefits of this technique and to compare its
      oncological outcome measures with those of conventional laparoscopy. In our
      experience, a low-profile port with a wide intra-abdominal range of motion is
      most preferable.
CI  - (c) 2012 The Authors. Colorectal Disease (c) 2012 The Association of
      Coloproctology of Great Britain and Ireland.
FAU - Mufty, H
AU  - Mufty H
AD  - Department of Abdominal Surgery, Jessa Hospital, Hasselt, Belgium.
FAU - Hillewaere, S
AU  - Hillewaere S
FAU - Appeltans, B
AU  - Appeltans B
FAU - Houben, B
AU  - Houben B
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Colorectal Dis
JT  - Colorectal disease : the official journal of the Association of Coloproctology of
      Great Britain and Ireland
JID - 100883611
SB  - IM
MH  - Adenocarcinoma/pathology/*surgery
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoid Tumor/pathology/*surgery
MH  - Colectomy/*methods
MH  - Colonic Neoplasms/pathology/*surgery
MH  - Digestive System Surgical Procedures/*instrumentation/methods
MH  - Female
MH  - Humans
MH  - Laparoscopy/*instrumentation/methods
MH  - Length of Stay
MH  - Male
MH  - Middle Aged
MH  - Operative Time
MH  - Prospective Studies
EDAT- 2012/07/11 06:00
MHDA- 2013/03/21 06:00
CRDT- 2012/07/11 06:00
PHST- 2012/07/11 06:00 [entrez]
PHST- 2012/07/11 06:00 [pubmed]
PHST- 2013/03/21 06:00 [medline]
AID - 10.1111/j.1463-1318.2012.03175.x [doi]
PST - ppublish
SO  - Colorectal Dis. 2012 Nov;14(11):e764-70. doi: 10.1111/j.1463-1318.2012.03175.x.


PMID- 22776249
OWN - NLM
STAT- MEDLINE
DCOM- 20130117
LR  - 20211021
IS  - 1477-7819 (Electronic)
IS  - 1477-7819 (Linking)
VI  - 10
DP  - 2012 Jul 9
TI  - A new complication of retained surgical gauze: development of malignant fibrous
      histiocytoma--report of a case with a literature review.
PG  - 139
LID - 10.1186/1477-7819-10-139 [doi]
AB  - BACKGROUND: Primary visceral malignant fibrous histiocytoma (MFH) is a rare
      disease, and few cases have been reported in the English literature. However,
      retained foreign bodies in the abdomen after surgical procedures are important
      causes of intra-abdominal infections. For legal and ethical reasons, there are
      few publications in the literature. In this article, we describe for the first
      time a case of malign abdominal fibrous histiocytoma associated with a surgical
      sponge forgotten in the abdominal cavity a long time ago. CASE PRESENTATION: A
      64-year-old male presented to our surgical department with cachexia, abdominal
      pain, distention and pyrexia of unknown origin. He had a medical history of
      abdominal surgery for peptic ulcer perforation 32 years ago. Clinical examination
      revealed fever with a distended and painful abdominal wall. Radiological imaging 
      of the abdomen showed multiple heterogeneous masses in one large cystic
      cavityalmost completely filling the abdomen. The patient underwent a laparotomy, 
      and interestingly, opening the cyst revealed retained surgical gauze (RSG). The
      origin of the tumor was the visceral peritoneum, and it was excised totally.
      CONCLUSIONS: Primary intra-abdominal MFH can present as a complication of
      long-lasting RSG. Therefore, clinicians must remember this while establishing the
      differential diagnosis for patients with a history of previous abdominal surgery 
      and presenting with symptoms associated with both the tumor and systemic
      inflammatory response.
FAU - Kaplan, Mehmet
AU  - Kaplan M
AD  - Department of General Surgery, Medical Park Gaziantep Hospital, Mucahitler mah,
      52063 sk, No:2 Sehitkamil, Gaziantep, 27090, Turkey. meplan69@hotmail.com
FAU - Iyikosker, Halil Ibrahim
AU  - Iyikosker HI
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20120709
PL  - England
TA  - World J Surg Oncol
JT  - World journal of surgical oncology
JID - 101170544
SB  - IM
MH  - Abdomen/microbiology/*pathology/surgery
MH  - Histiocytoma, Malignant Fibrous/*etiology/*pathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Postoperative Complications
MH  - Prognosis
MH  - Surgical Sponges/*adverse effects
PMC - PMC3411509
EDAT- 2012/07/11 06:00
MHDA- 2013/01/18 06:00
CRDT- 2012/07/11 06:00
PHST- 2012/02/28 00:00 [received]
PHST- 2012/07/09 00:00 [accepted]
PHST- 2012/07/11 06:00 [entrez]
PHST- 2012/07/11 06:00 [pubmed]
PHST- 2013/01/18 06:00 [medline]
AID - 1477-7819-10-139 [pii]
AID - 10.1186/1477-7819-10-139 [doi]
PST - epublish
SO  - World J Surg Oncol. 2012 Jul 9;10:139. doi: 10.1186/1477-7819-10-139.


PMID- 22776022
OWN - NLM
STAT- MEDLINE
DCOM- 20130401
LR  - 20181202
IS  - 1555-3892 (Electronic)
IS  - 0963-6897 (Linking)
VI  - 21
IP  - 8
DP  - 2012
TI  - In vivo differentiation of human amniotic epithelial cells into
      cardiomyocyte-like cells and cell transplantation effect on myocardial infarction
      in rats: comparison with cord blood and adipose tissue-derived mesenchymal stem
      cells.
PG  - 1687-96
LID - 10.3727/096368912X653039 [doi]
AB  - Human amniotic epithelial cells (h-AECs), which have various merits as a cell
      source for cell therapy, are known to differentiate into cardiomyocytes in vitro.
      However, the ability of h-AECs to differentiate into cardiomyocytes in vivo and
      their cell transplantation effects on myocardial infarction are still unknown. In
      this study, we assessed whether h-AECs could differentiate into cardiomyocytes in
      vivo and whether h-AECs transplantation can decrease infarct size and improve
      cardiac function, in comparison to transplantation of cord blood-derived
      mesenchymal stem cells (MSCs) or adipose tissue-derived MSCs. For our study, we
      injected h-AECs, cord blood-derived MSCs, adipose tissue-derived MSCs, and saline
      into areas of myocardial infarction in athymic nude rats. After 4 weeks, 3% of
      the surviving h-AECs expressed myosin heavy chain, a marker specific to the
      myocardium. Compared with the saline group, all cell-implanted groups showed a
      higher ejection fraction, lower infarct area by positron emission tomography and 
      histology, and more abundant myocardial gene and protein expression in the
      infarct area. We showed that h-AECs can differentiate into cardiomyocyte-like
      cells, decrease infarct size, and improve cardiac function in vivo. The
      beneficial effects of h-AECs were comparable to those of cord blood and adipose
      tissue-derived MSCs. These results support the need for further studies of h-AECs
      as a cell source for myocardial regeneration due to their plentiful availability,
      low immunity, and lack of ethical issues related to their use.
FAU - Fang, Cheng-Hu
AU  - Fang CH
AD  - Division of Cardiology, Hanyang University College of Medicine, Seoul, South
      Korea.
FAU - Jin, Jiyong
AU  - Jin J
FAU - Joe, Jun-Ho
AU  - Joe JH
FAU - Song, Yi-Sun
AU  - Song YS
FAU - So, Byung-Im
AU  - So BI
FAU - Lim, Sang Moo
AU  - Lim SM
FAU - Cheon, Gi Jeong
AU  - Cheon GJ
FAU - Woo, Sang-Keun
AU  - Woo SK
FAU - Ra, Jeong-Chan
AU  - Ra JC
FAU - Lee, Young-Yiul
AU  - Lee YY
FAU - Kim, Kyung-Soo
AU  - Kim KS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120705
PL  - United States
TA  - Cell Transplant
JT  - Cell transplantation
JID - 9208854
RN  - EC 3.6.4.1 (Myosin Heavy Chains)
SB  - IM
MH  - Adipose Tissue/*cytology
MH  - Amnion/*cytology
MH  - Animals
MH  - Cell Differentiation
MH  - Echocardiography
MH  - Epithelial Cells/*cytology/transplantation
MH  - Fetal Blood/*cytology
MH  - Humans
MH  - Male
MH  - Mesenchymal Stem Cell Transplantation
MH  - Mesenchymal Stem Cells/*cytology
MH  - Myocardial Infarction/diagnostic imaging/pathology/*therapy
MH  - Myocytes, Cardiac/*metabolism
MH  - Myosin Heavy Chains/metabolism
MH  - Positron-Emission Tomography
MH  - Radiography
MH  - Rats
MH  - Rats, Nude
EDAT- 2012/07/11 06:00
MHDA- 2013/04/02 06:00
CRDT- 2012/07/11 06:00
PHST- 2012/07/11 06:00 [entrez]
PHST- 2012/07/11 06:00 [pubmed]
PHST- 2013/04/02 06:00 [medline]
AID - ct0418fang [pii]
AID - 10.3727/096368912X653039 [doi]
PST - ppublish
SO  - Cell Transplant. 2012;21(8):1687-96. doi: 10.3727/096368912X653039. Epub 2012 Jul
      5.


PMID- 22775783
OWN - NLM
STAT- MEDLINE
DCOM- 20121206
LR  - 20120710
IS  - 1532-8015 (Electronic)
IS  - 1040-1334 (Linking)
VI  - 24
IP  - 3
DP  - 2012
TI  - Medical students hierarchy of values and sense of responsibility.
PG  - 211-4
LID - 10.1080/10401334.2012.692264 [doi]
AB  - BACKGROUND: Ethical skills and personal values contribute to making students
      competent and humane physicians. However, there is not much research done on
      medical students' personal values and sense of responsibility. PURPOSES: The
      study was designed to examine differences in personal values and sense of
      responsibility between medical students and their peers. METHODS: The students
      performed demographic survey and reliable tests: Scheler's Value Scale and
      Responsibility Scale. RESULTS: Medical students scored higher in responsibility, 
      also in values of hedonism and truth, and scored lower in values of holy, both
      religion and secularism. They did not differ from the control group in values of 
      vitality, aesthetics, morals, physical fitness as well as strength and stamina.
      CONCLUSION: Medical students differ from their peers from other faculties at the 
      level of responsibility and hierarchy of values. They rate higher at such values 
      as hedonism and truth and lower values of holy.
FAU - Pawelczyk, Agnieszka
AU  - Pawelczyk A
AD  - Department of Affective and Psychotic Disorders, Medical University of Lodz,
      Lodz, Poland. agpawelczyk@gmail.com
FAU - Pawelczyk, Tomasz
AU  - Pawelczyk T
FAU - Rabe-Jablonska, Jolanta
AU  - Rabe-Jablonska J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Teach Learn Med
JT  - Teaching and learning in medicine
JID - 8910884
SB  - IM
MH  - Chi-Square Distribution
MH  - Data Collection
MH  - Female
MH  - Humans
MH  - Male
MH  - Peer Group
MH  - *Philosophy
MH  - Poland
MH  - *Social Responsibility
MH  - *Social Values
MH  - Statistics as Topic
MH  - Students, Medical/*psychology
MH  - Young Adult
EDAT- 2012/07/11 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/11 06:00
PHST- 2012/07/11 06:00 [entrez]
PHST- 2012/07/11 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1080/10401334.2012.692264 [doi]
PST - ppublish
SO  - Teach Learn Med. 2012;24(3):211-4. doi: 10.1080/10401334.2012.692264.


PMID- 22775766
OWN - NLM
STAT- MEDLINE
DCOM- 20130805
LR  - 20130215
IS  - 1365-2648 (Electronic)
IS  - 0309-2402 (Linking)
VI  - 69
IP  - 3
DP  - 2013 Mar
TI  - Generational diversity: what nurse managers need to know.
PG  - 717-25
LID - 10.1111/j.1365-2648.2012.06079.x [doi]
AB  - AIM: This article presents a discussion of generational differences and their
      impact on the nursing workforce and how this impact affects the work environment.
      BACKGROUND: The global nursing workforce represents four generations of nurses.
      This generational diversity frames attitudes, beliefs, work habits and
      expectations associated with the role of the nurse in the provision of care and
      in the way the nurse manages their day-to-day activities. DATA SOURCES: An
      electronic search of MEDLINE, PubMed and Cinahl databases was performed using the
      words generational diversity, nurse managers and workforce. The search was
      limited to 2000-2012. DISCUSSION: Generational differences present challenges to 
      contemporary nurse managers working in a healthcare environment which is complex 
      and dynamic, in terms of managing nurses who think and behave in a different way 
      because of disparate core personal and generational values, namely, the three Cs 
      of communication, commitment and compensation. IMPLICATIONS FOR NURSING: An
      acceptance of generational diversity in the workplace allows a richer scope for
      practice as the experiences and knowledge of each generation in the nursing
      environment creates an environment of acceptance and harmony facilitating
      retention of nurses. CONCLUSION: Acknowledgement of generational characteristics 
      provides the nurse manager with strategies which focus on mentoring and
      motivation; communication, the increased use of technology and the ethics of
      nursing, to bridge the gap between generations of nurses and to increase nursing 
      workforce cohesion.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Hendricks, Joyce M
AU  - Hendricks JM
AD  - School of Nursing, Midwifery and Post Graduate Medicine, Edith Cowan University, 
      Joondalup, Western Australia, Australia. j.hendricks@ecu.edu.au
FAU - Cope, Vicki C
AU  - Cope VC
LA  - eng
PT  - Historical Article
PT  - Journal Article
DEP - 20120709
PL  - England
TA  - J Adv Nurs
JT  - Journal of advanced nursing
JID - 7609811
SB  - IM
MH  - Age Factors
MH  - *Attitude of Health Personnel
MH  - Communication
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - *Intergenerational Relations
MH  - Nurse Administrators/psychology
MH  - Nurse's Role/*psychology
MH  - Nurses/*psychology
MH  - Nursing Staff/organization & administration
MH  - Workplace
EDAT- 2012/07/11 06:00
MHDA- 2013/08/06 06:00
CRDT- 2012/07/11 06:00
PHST- 2012/05/26 00:00 [accepted]
PHST- 2012/07/11 06:00 [entrez]
PHST- 2012/07/11 06:00 [pubmed]
PHST- 2013/08/06 06:00 [medline]
AID - 10.1111/j.1365-2648.2012.06079.x [doi]
PST - ppublish
SO  - J Adv Nurs. 2013 Mar;69(3):717-25. doi: 10.1111/j.1365-2648.2012.06079.x. Epub
      2012 Jul 9.


PMID- 22775524
OWN - NLM
STAT- MEDLINE
DCOM- 20130108
LR  - 20131106
IS  - 1744-7682 (Electronic)
IS  - 1471-2598 (Linking)
VI  - 12
IP  - 9
DP  - 2012 Sep
TI  - Clinical development of IMOJEV (R)--a recombinant Japanese encephalitis chimeric 
      vaccine (JE-CV).
PG  - 1251-63
LID - 10.1517/14712598.2012.704908 [doi]
AB  - INTRODUCTION: Japanese encephalitis (JE) is a disease of the central nervous
      system (CNS) caused by Japanese encephalitis virus (JEV). JE is endemic in most
      of the South-East Asian countries and in some parts of the Western Pacific. As
      mosquito control is ineffective, currently vaccination is the only available
      control measure. A mouse brain-derived inactivated JE vaccine (MBDV) has been in 
      use for a long time; however, it is not feasible for mass vaccination due to the 
      ethical and safety issues. With the World Health Organization (WHO) appealing for
      the development of novel, safe and affordable JE vaccines, several vaccine
      candidates have been developed in the recent times and IMOJEV (R) is one among
      them. AREAS COVERED: This review presents a brief account of various
      developmental, immunological and ethical issues related to IMOJEV(R) and provides
      an in-depth account of its clinical development and efficacy in comparison to
      other JE vaccines. EXPERT OPINION: IMOJEV(R) is a safe and efficacious vaccine.
      If made affordable through financial assistance from health agencies or by its
      production in set ups where operational costs are lower, it may become an ideal
      vaccine for mass vaccination in JE endemic regions.
FAU - Appaiahgari, Mohan Babu
AU  - Appaiahgari MB
AD  - Vaccine and Infectious Disease Research Centre, Translational Health Science and 
      Technology Institute, 496, UdyogVihar Phase III, Gurgaon 122016, India.
FAU - Vrati, Sudhanshu
AU  - Vrati S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120709
PL  - England
TA  - Expert Opin Biol Ther
JT  - Expert opinion on biological therapy
JID - 101125414
RN  - 0 (Japanese Encephalitis Vaccines)
RN  - 0 (Vaccines, Synthetic)
SB  - IM
MH  - Animals
MH  - Asia
MH  - Drug Costs
MH  - Encephalitis Virus, Japanese/*immunology/pathogenicity
MH  - Encephalitis, Japanese/economics/epidemiology/immunology/*prevention &
      control/virology
MH  - Endemic Diseases/economics/*prevention & control
MH  - Humans
MH  - *Japanese Encephalitis Vaccines/administration & dosage/adverse effects/economics
MH  - *Mass Vaccination/economics
MH  - Mosquito Control
MH  - Treatment Outcome
MH  - Vaccines, Synthetic
EDAT- 2012/07/11 06:00
MHDA- 2013/01/09 06:00
CRDT- 2012/07/11 06:00
PHST- 2012/07/11 06:00 [entrez]
PHST- 2012/07/11 06:00 [pubmed]
PHST- 2013/01/09 06:00 [medline]
AID - 10.1517/14712598.2012.704908 [doi]
PST - ppublish
SO  - Expert Opin Biol Ther. 2012 Sep;12(9):1251-63. doi: 10.1517/14712598.2012.704908.
      Epub 2012 Jul 9.


PMID- 22775457
OWN - NLM
STAT- MEDLINE
DCOM- 20121205
LR  - 20211021
IS  - 2152-4998 (Electronic)
IS  - 2152-4971 (Linking)
VI  - 14
IP  - 4
DP  - 2012 Aug
TI  - Proliferative capacity and pluripotent characteristics of porcine adult stem
      cells derived from adipose tissue and bone marrow.
PG  - 342-52
LID - 10.1089/cell.2011.0098 [doi]
AB  - Direct reprogramming of somatic cells to induced pluripotent stem cells (iPSCs)
      provides an invaluable resource for regenerative medicine. Because of some
      ethical and logistical barriers, human iPSCs cannot be used to generate a
      chimera, which is one of markers representing pluripotency. As the most
      attractive model for preclinical studies, pigs offer another path to improve
      clinical medicine. In this study, porcine adult stem cells (pASCs), including
      adipose mesenchymal stem cells (AMSCs) and bone marrow mesenchymal stem cells
      (BMSCs), were collected and cultured under the same conditions in vitro.
      Real-time PCR, immunocytochemical staining, apoptosis analysis, and induced
      differentiation and reprogramming techniques were used to investigate the
      proliferative capacity and pluripotent characteristics of pASCs. Our results
      showed that both AMSCs and BMSCs displayed a similar immunophenotype, and their
      proliferative capacity appeared as a downward trend as the cell passage number
      increased. The cell proliferative capacity of AMSCs was significantly lower than 
      that of BMSCs (p<0.05). Moreover, each type of pASCs went through 20 passages
      without undergoing alterations in the expression of reprogramming transcriptional
      factors (Oct4, Sox2, c-Myc, and Nanog). All pASCs had adipogenic and osteogenic
      differentiation potential. In addition, they also could be reprogrammed to pig
      induced pluripotent stem cells (piPSCs) with similar time and efficiency. In
      conclusion, porcine BMSCs had a higher proliferative capacity than AMSCs, and the
      pluripotency of pASCs was stable in long-term culture.
FAU - Tang, Lina
AU  - Tang L
AD  - Jilin Provincial Key Laboratory of Animal Embryo Engineering, the Center for
      Animal Embryo Engineering of Jilin Province, College of Animal Science and
      Veterinary Medicine, Jilin University, Changchun, Jilin, China.
FAU - Yin, Yupeng
AU  - Yin Y
FAU - Zhou, Haole
AU  - Zhou H
FAU - Song, Guangqi
AU  - Song G
FAU - Fan, Anran
AU  - Fan A
FAU - Tang, Bo
AU  - Tang B
FAU - Shi, Wei
AU  - Shi W
FAU - Li, Ziyi
AU  - Li Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120709
PL  - United States
TA  - Cell Reprogram
JT  - Cellular reprogramming
JID - 101528176
RN  - 0 (Transcription Factors)
SB  - IM
MH  - *Adipose Tissue/cytology/metabolism
MH  - *Adult Stem Cells/cytology/metabolism
MH  - Animals
MH  - *Bone Marrow Cells/cytology/metabolism
MH  - Humans
MH  - Mesenchymal Stem Cells/cytology/metabolism
MH  - *Pluripotent Stem Cells/cytology/metabolism
MH  - Swine
MH  - Transcription Factors/*biosynthesis
PMC - PMC3411367
EDAT- 2012/07/11 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/11 06:00
PHST- 2012/07/11 06:00 [entrez]
PHST- 2012/07/11 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1089/cell.2011.0098 [doi]
PST - ppublish
SO  - Cell Reprogram. 2012 Aug;14(4):342-52. doi: 10.1089/cell.2011.0098. Epub 2012 Jul
      9.


PMID- 22774936
OWN - NLM
STAT- MEDLINE
DCOM- 20130902
LR  - 20181202
IS  - 1502-4725 (Electronic)
IS  - 0803-9488 (Linking)
VI  - 67
IP  - 2
DP  - 2013 Apr
TI  - Staff's perception of adolescent aggressive behaviour in four European forensic
      units: a qualitative interview study.
PG  - 124-31
LID - 10.3109/08039488.2012.697190 [doi]
AB  - BACKGROUND: Aggressive behaviour among patients is extremely common in forensic
      adolescent psychiatry compromising the safety of the treatment milieu and posing 
      a treatment challenge to the staff. The staff's perception of aggression is
      likely to contribute to the aggression management practices among disturbed
      adolescents. AIMS: To examine staff's perceptions of adolescent aggressive
      behaviour and factors contributing it. METHODS: Qualitative interviews were
      conducted in four adolescent forensic units in four European countries. Data was 
      analysed using qualitative content analysis. FINDINGS: Aggressive behaviour was
      perceived to be verbal and physical in nature with various levels of severity.
      Several factors were perceived to contribute to aggressive acts, including
      adolescents' early life experiences. Participants mainly shared perceptions of
      adolescent aggressive behaviour in the four units studied. CONCLUSIONS: The study
      provides new international knowledge about how staff perceive adolescent
      aggressive behaviour in the forensic setting. The shared understanding of
      adolescents' aggressive behaviour enables the implementation of safe, ethically
      sound and more consistent aggression management in clinical forensic practice.
      Reduced occurrence of aggression may improve the therapeutic milieu of the unit
      and may strengthen the staff's occupational health.
FAU - Berg, Johanna
AU  - Berg J
AD  - University of Turku, Department of Nursing Science, Turku, Finland.
      johanna.berg@turkuamk.fi
FAU - Kaltiala-Heino, Riittakerttu
AU  - Kaltiala-Heino R
FAU - Loyttyniemi, Varpu
AU  - Loyttyniemi V
FAU - Valimaki, Maritta
AU  - Valimaki M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120710
PL  - England
TA  - Nord J Psychiatry
JT  - Nordic journal of psychiatry
JID - 100927567
SB  - IM
MH  - Adolescent
MH  - Adolescent Behavior
MH  - Adult
MH  - Aged
MH  - Aggression/*psychology
MH  - *Attitude of Health Personnel
MH  - Child
MH  - Europe
MH  - Female
MH  - Forensic Psychiatry/*statistics & numerical data
MH  - Humans
MH  - Inpatients
MH  - Internationality
MH  - Male
MH  - Middle Aged
MH  - Qualitative Research
MH  - Young Adult
EDAT- 2012/07/11 06:00
MHDA- 2013/09/03 06:00
CRDT- 2012/07/11 06:00
PHST- 2012/07/11 06:00 [entrez]
PHST- 2012/07/11 06:00 [pubmed]
PHST- 2013/09/03 06:00 [medline]
AID - 10.3109/08039488.2012.697190 [doi]
PST - ppublish
SO  - Nord J Psychiatry. 2013 Apr;67(2):124-31. doi: 10.3109/08039488.2012.697190. Epub
      2012 Jul 10.


PMID- 22774760
OWN - NLM
STAT- MEDLINE
DCOM- 20121101
LR  - 20191210
IS  - 1469-9532 (Electronic)
IS  - 1366-8250 (Linking)
VI  - 37
IP  - 3
DP  - 2012 Sep
TI  - The efficacy of positive behavioural support with the most challenging behaviour:
      the evidence and its implications.
PG  - 185-95
LID - 10.3109/13668250.2012.696597 [doi]
AB  - BACKGROUND: Positive behaviour support (PBS) is behaviour analysis applied in
      support of people with challenging behaviour. Questions have been raised as to
      PBS effectiveness, costs, and accessibility. METHOD: Outcome studies meeting
      specified criteria for PBS were selected for review. All told, 12 outcome studies
      encompassing 423 cases were included. RESULTS: This review showed that PBS was
      effective with both severe and high-rate behaviour problems, was cost-effective, 
      used a methodology that was easily trained and widely disseminated, and worked in
      institutional settings in which the most difficult problems are thought to be, as
      well as in the community. CONCLUSIONS: The major implication of this review is
      that practitioners may be obligated to use PBS when faced with the need to
      develop a plan of support given the ethical principle of using the least
      restrictive method consistent with the right to effective treatment.
FAU - LaVigna, Gary W
AU  - LaVigna GW
AD  - Institute for Applied Behavior Analysis, Los Angeles, CA 90045, USA.
      glavigna@iaba.com
FAU - Willis, Thomas J
AU  - Willis TJ
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120710
PL  - England
TA  - J Intellect Dev Disabil
JT  - Journal of intellectual & developmental disability
JID - 9610837
SB  - IM
MH  - Behavior Therapy/*methods
MH  - *Cost-Benefit Analysis
MH  - Evidence-Based Medicine
MH  - Health Services Accessibility
MH  - Humans
MH  - Mental Disorders/economics/*therapy
MH  - Outcome and Process Assessment, Health Care
MH  - Severity of Illness Index
MH  - *Social Support
EDAT- 2012/07/11 06:00
MHDA- 2012/11/02 06:00
CRDT- 2012/07/11 06:00
PHST- 2012/07/11 06:00 [entrez]
PHST- 2012/07/11 06:00 [pubmed]
PHST- 2012/11/02 06:00 [medline]
AID - 10.3109/13668250.2012.696597 [doi]
PST - ppublish
SO  - J Intellect Dev Disabil. 2012 Sep;37(3):185-95. doi:
      10.3109/13668250.2012.696597. Epub 2012 Jul 10.


PMID- 22774278
OWN - NLM
STAT- MEDLINE
DCOM- 20120724
LR  - 20181201
IS  - 2046-2336 (Print)
IS  - 2046-2336 (Linking)
VI  - 24
IP  - 4
DP  - 2012 May
TI  - Maintaining good practice in the administration of medicines to children.
PG  - 29-35; quiz 36
AB  - This article discusses the role of the children's nurse in the administration of 
      medicines to children. What is meant by the phrase 'off label' is explained,
      along with the legal processes involved in ensuring medicines are safe to be
      administered to children, and the ethical issues behind the practice of crushing 
      and disguising medication. Areas where errors can occur are identified and the
      importance of assessing each child and minimising harm are emphasised.
FAU - Crawford, Doreen
AU  - Crawford D
AD  - De Montfort University, Leicester. dcraw@dmu.ac.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Child Young People
JT  - Nursing children and young people
JID - 101554473
MH  - Child
MH  - Documentation
MH  - *Drug Therapy
MH  - Education, Nursing, Continuing
MH  - Humans
MH  - Nursing Records
MH  - Patient Education as Topic
MH  - *Pediatric Nursing
MH  - *Quality of Health Care
MH  - Workforce
EDAT- 2012/07/11 06:00
MHDA- 2012/07/25 06:00
CRDT- 2012/07/11 06:00
PHST- 2012/07/11 06:00 [entrez]
PHST- 2012/07/11 06:00 [pubmed]
PHST- 2012/07/25 06:00 [medline]
AID - 10.7748/ncyp2012.05.24.4.29.c9092 [doi]
PST - ppublish
SO  - Nurs Child Young People. 2012 May;24(4):29-35; quiz 36. doi:
      10.7748/ncyp2012.05.24.4.29.c9092.


PMID- 22774235
OWN - NLM
STAT- MEDLINE
DCOM- 20120828
LR  - 20191210
IS  - 1422-4917 (Print)
IS  - 1422-4917 (Linking)
VI  - 40
IP  - 3
DP  - 2012 May
TI  - [Increase in incidence of drug treatments, ethical principles and conflict of
      interest in cooperation with the pharmaceutical industry].
PG  - 133-8
FAU - Hebebrand, Johannes
AU  - Hebebrand J
FAU - Blanz, Bernhard
AU  - Blanz B
FAU - Herpertz-Dahlmann, Beate
AU  - Herpertz-Dahlmann B
FAU - Lehmkuhl, Gerd
AU  - Lehmkuhl G
LA  - ger
PT  - Editorial
TT  - Zunahme der Haufigkeit medikamentoser Behandlungen, ethische Prinzipien und
      Interessenkonflikte in der Kooperation mit der pharmazeutischen Industrie.
PL  - Switzerland
TA  - Z Kinder Jugendpsychiatr Psychother
JT  - Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie
JID - 9801717
RN  - 0 (Psychotropic Drugs)
SB  - IM
CIN - Z Kinder Jugendpsychiatr Psychother. 2013 Mar;41(2):145-9. PMID: 23425616
MH  - Adolescent
MH  - Advertising/economics/ethics/trends
MH  - Child
MH  - Child Behavior Disorders/*drug therapy/*economics
MH  - Conflict of Interest/*economics
MH  - *Cooperative Behavior
MH  - Drug Costs/ethics/trends
MH  - Drug Industry/*economics/*ethics
MH  - Drug Utilization/economics/ethics/trends
MH  - *Ethics, Medical
MH  - Germany
MH  - Health Planning Guidelines
MH  - Humans
MH  - *Interdisciplinary Communication
MH  - Mental Disorders/*drug therapy
MH  - Practice Patterns, Physicians'/*economics/*ethics
MH  - Psychotropic Drugs/*economics/*supply & distribution/*therapeutic use
MH  - United States
EDAT- 2012/07/10 06:00
MHDA- 2012/08/29 06:00
CRDT- 2012/07/10 06:00
PHST- 2012/07/10 06:00 [entrez]
PHST- 2012/07/10 06:00 [pubmed]
PHST- 2012/08/29 06:00 [medline]
AID - 10.1024/1422-4917/a000163 [doi]
PST - ppublish
SO  - Z Kinder Jugendpsychiatr Psychother. 2012 May;40(3):133-8. doi:
      10.1024/1422-4917/a000163.


PMID- 22774222
OWN - NLM
STAT- MEDLINE
DCOM- 20130110
LR  - 20121018
IS  - 1472-4146 (Electronic)
IS  - 0021-9746 (Linking)
VI  - 65
IP  - 11
DP  - 2012 Nov
TI  - Retrospective review of diagnostic histopathology samples in research projects:
      transparency should be the practice with respect to diagnostic discordance.
PG  - 1043-4
LID - 10.1136/jclinpath-2012-200788 [doi]
AB  - Retrospective review of diagnostic histopathology samples in secondary research
      projects may generate cases with discordance in diagnosis between the pathologist
      originally signing out the sample and the reviewer. In this article the authors
      discuss ethical and legal issues involved in secondary review and propose how
      diagnostic discrepancies in research projects can be handled. Research
      participants have the right to know about and control the handling of personal
      data. Researchers have a duty to inform research participants about research
      findings of relevance to the current or future health or quality of life. Such
      feedback is to be provided within a healthcare framework. The authors recommend
      that pathology laboratories should require researchers to provide feedback on
      diagnostic discrepancies of potentially clinical significance in secondary
      research projects using retrospective review of diagnostic histopathology
      material. The pathology laboratory in charge of the archival material should be
      responsible for the follow-up on such cases.
FAU - Bjugn, Roger
AU  - Bjugn R
AD  - Biobank and Medical Registry Unit, Oslo University Hospital, Oslo, Norway.
      rogbju@ous-hf.no
FAU - Casati, Bettina
AU  - Casati B
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120706
PL  - England
TA  - J Clin Pathol
JT  - Journal of clinical pathology
JID - 0376601
SB  - IM
MH  - Biological Specimen Banks/*ethics/*legislation & jurisprudence
MH  - Biomedical Research/*ethics
MH  - Confidentiality
MH  - Diagnosis, Differential
MH  - Disclosure
MH  - *Ethics, Research
MH  - Humans
MH  - Pathology/*standards
MH  - Patient Access to Records
MH  - Reproducibility of Results
MH  - Retrospective Studies
EDAT- 2012/07/10 06:00
MHDA- 2013/01/11 06:00
CRDT- 2012/07/10 06:00
PHST- 2012/07/10 06:00 [entrez]
PHST- 2012/07/10 06:00 [pubmed]
PHST- 2013/01/11 06:00 [medline]
AID - jclinpath-2012-200788 [pii]
AID - 10.1136/jclinpath-2012-200788 [doi]
PST - ppublish
SO  - J Clin Pathol. 2012 Nov;65(11):1043-4. doi: 10.1136/jclinpath-2012-200788. Epub
      2012 Jul 6.


PMID- 22773953
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 2150-7716 (Print)
IS  - 2150-7724 (Linking)
VI  - 3
IP  - 3
DP  - 2012 Jul 1
TI  - Ethical Discourse about the Modification of Food for Therapeutic Purposes: How
      Patients with Gastrointestinal Diseases View the Good, the Bad, and the Healthy.
PG  - 12-20
AB  - BACKGROUND: Researchers have the potential to utilize genetic modification (GM)
      technologies to create a hybrid of "food" and "medicine" that may challenge
      traditional understandings of what is "natural". Moral and ethical concerns are
      likely to arise in any discussion of these therapeutic foods and will affect the 
      integration of products into clinical care and daily life. This study examined
      how patients with chronic gastrointestinal (GI) diseases view probiotics as
      future bioengineered therapeutic foods. METHODS: A multi-site qualitative study
      consisting of focus groups with chronic GI diseases was conducted at Cleveland
      Clinic, Mayo Clinic, and Johns Hopkins University RESULTS: We conducted
      twenty-two focus groups with 136 patients with major GI diseases between March
      and August 2009. GI patients associated the term "natural" with concepts of
      diminished risk and morally "good"; conversely, patients associated the term
      "unnatural" with things that are "risky," "foreign", and morally "bad". Readily
      available unmodified probiotics were more commonly described as "natural" while
      genetically modified probiotics were more commonly labeled as "unnatural" and
      "risky". However, patients acknowledged that not all natural products are safe,
      nor are unnatural products always harmful. CONCLUSIONS: If GI patient
      perspectives are indicative of public perceptions of therapeutic foods, our
      findings suggest that the potential benefits and risks of clinical and public
      health initiatives employing therapeutic foods will be understood in moralistic
      terms. Bioethicists and others should be sensitive to the implicit normative
      appeals that are often embedded in the language of what is "natural" and
      "unnatural".
FAU - Harrison, Krista L
AU  - Harrison KL
AD  - Berman Institute of Bioethics, Johns Hopkins University, Baltimore, MD, United
      States.
FAU - Geller, Gail
AU  - Geller G
FAU - Marshall, Patricia
AU  - Marshall P
FAU - Tilburt, Jon
AU  - Tilburt J
FAU - Mercer, Marybeth
AU  - Mercer M
FAU - Brinich, Margaret A
AU  - Brinich MA
FAU - Highland, Janelle
AU  - Highland J
FAU - Farrell, Ruth M
AU  - Farrell RM
FAU - Sharp, Richard R
AU  - Sharp RR
LA  - eng
GR  - R01 HG004877/HG/NHGRI NIH HHS/United States
PT  - Journal Article
DEP - 20120619
PL  - United States
TA  - AJOB Prim Res
JT  - AJOB primary research
JID - 101520734
PMC - PMC3389757
MID - NIHMS386977
EDAT- 2012/07/10 06:00
MHDA- 2012/07/10 06:01
CRDT- 2012/07/10 06:00
PHST- 2012/07/10 06:00 [entrez]
PHST- 2012/07/10 06:00 [pubmed]
PHST- 2012/07/10 06:01 [medline]
AID - 10.1080/21507716.2012.662574 [doi]
PST - ppublish
SO  - AJOB Prim Res. 2012 Jul 1;3(3):12-20. doi: 10.1080/21507716.2012.662574. Epub
      2012 Jun 19.


PMID- 22773950
OWN - NLM
STAT- MEDLINE
DCOM- 20130704
LR  - 20211021
IS  - 2046-2441 (Electronic)
IS  - 2046-2441 (Linking)
VI  - 2
IP  - 6
DP  - 2012 Jun
TI  - Non-invasive prenatal diagnosis by massively parallel sequencing of maternal
      plasma DNA.
PG  - 120086
LID - 10.1098/rsob.120086 [doi]
AB  - The presence of foetal DNA in the plasma of pregnant women has opened up new
      possibilities for non-invasive prenatal diagnosis. The use of circulating foetal 
      DNA for the non-invasive prenatal detection of foetal chromosomal aneuploidies is
      challenging as foetal DNA represents a minor fraction of maternal plasma DNA. In 
      2007, it was shown that single molecule counting methods would allow the
      detection of the presence of a trisomic foetus, as long as enough molecules were 
      counted. With the advent of massively parallel sequencing, millions or billions
      of DNA molecules can be readily counted. Using massively parallel sequencing,
      foetal trisomies 21, 13 and 18 have been detected from maternal plasma. Recently,
      large-scale clinical studies have validated the robustness of this approach for
      the prenatal detection of foetal chromosomal aneuploidies. A proof-of-concept
      study has also shown that a genome-wide genetic and mutational map of a foetus
      can be constructed from the maternal plasma DNA sequencing data. These
      developments suggest that the analysis of foetal DNA in maternal plasma would
      play an increasingly important role in future obstetrics practice. It is thus a
      priority that the ethical, social and legal issues regarding this technology be
      systematically studied.
FAU - Lo, Yuk Ming Dennis
AU  - Lo YM
AD  - Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong,
      Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, People's
      Republic of China. loym@cuhk.edu.hk
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Open Biol
JT  - Open biology
JID - 101580419
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - *Aneuploidy
MH  - DNA/*blood/*genetics
MH  - DNA Mutational Analysis/methods
MH  - Female
MH  - Fetus/metabolism
MH  - Humans
MH  - Pregnancy
MH  - Prenatal Diagnosis/*methods
PMC - PMC3390796
OTO - NOTNLM
OT  - Down syndrome
OT  - foetal DNA in maternal plasma
OT  - next-generation sequencing
OT  - plasma nucleic acids
OT  - trisomy 21
GN  - NLM: Original DateCompleted: 20120823
EDAT- 2012/07/10 06:00
MHDA- 2012/07/10 06:01
CRDT- 2012/07/10 06:00
PHST- 2012/05/03 00:00 [received]
PHST- 2012/05/14 00:00 [accepted]
PHST- 2012/07/10 06:00 [entrez]
PHST- 2012/07/10 06:00 [pubmed]
PHST- 2012/07/10 06:01 [medline]
AID - 10.1098/rsob.120086 [doi]
AID - rsob120086 [pii]
PST - ppublish
SO  - Open Biol. 2012 Jun;2(6):120086. doi: 10.1098/rsob.120086.


PMID- 22773609
OWN - NLM
STAT- MEDLINE
DCOM- 20140320
LR  - 20211203
IS  - 1460-2245 (Electronic)
IS  - 0957-4824 (Linking)
VI  - 28
IP  - 3
DP  - 2013 Sep
TI  - The impact of community-based, workshop activities in multiple local dialects on 
      the vaccination coverage, sanitary living and the health status of multiethnic
      populations in Lao PDR.
PG  - 453-65
LID - 10.1093/heapro/das030 [doi]
AB  - Studies on effective community-based intervention in areas inhabited by multiple 
      ethnic groups are limited. The present study was performed to evaluate the impact
      of workshop activities in multiple local dialects guided by lay facilitators on
      vaccination coverage, sanitary living and health status in a northern district of
      Lao PDR. In target villages, facilitators were selected and trained to assist at 
      village meetings to discuss health issues and develop and implement action plans.
      Manuals and posters with graphics were distributed. Skills were taught through
      demonstrations by specialists. The vaccination coverage among children and women 
      improved significantly after 1 year. Villagers started using toilets, collecting 
      and burning garbage, and isolating animals from human dwellings, and these
      activities were continued in 76, 84 and 87% of villages, respectively, 5 years
      after the start of the activities. The frequency of villagers falling ill was
      reduced in 67% of the villages. After adjustment for sociocultural
      characteristics and ethnicity, both the continuous sanitary living index and the 
      reduction in the frequency of villagers falling ill were associated with the
      higher levels of community participation in the workshop activities. The results 
      demonstrated that the community-based workshop activities improved vaccination
      coverage, sanitary living and health status. Participatory group discussions in
      local dialects and village activities led by lay facilitators, supervision and
      consultation by district trainers who were well recognized by villagers, and the 
      distribution of pictorial educational materials can be an effective and
      sustainable health promotion approaches among multiethnic groups in
      under-resourced areas.
FAU - Keoprasith, Bounserth
AU  - Keoprasith B
AD  - Section of Health Promotion, Graduate School of Medical and Dental Sciences,
      Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo City, Tokyo 113-8519,
      Japan.
FAU - Kizuki, Masashi
AU  - Kizuki M
FAU - Watanabe, Masafumi
AU  - Watanabe M
FAU - Takano, Takehito
AU  - Takano T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120706
PL  - England
TA  - Health Promot Int
JT  - Health promotion international
JID - 9008939
RN  - 0 (Tetanus Toxoid)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Community Health Services/methods
MH  - Education/methods
MH  - Ethnicity/statistics & numerical data
MH  - Female
MH  - Health Education/methods
MH  - Health Promotion/*methods
MH  - *Health Status
MH  - Humans
MH  - Infant
MH  - Language
MH  - Laos/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Public Health/methods/standards
MH  - Sanitation/standards/*statistics & numerical data
MH  - Tetanus Toxoid/therapeutic use
MH  - Vaccination/*statistics & numerical data
MH  - Young Adult
OTO - NOTNLM
OT  - Lao PDR
OT  - community action
OT  - ethic differences
OT  - health behavior
OT  - implementation strategies
EDAT- 2012/07/10 06:00
MHDA- 2014/03/22 06:00
CRDT- 2012/07/10 06:00
PHST- 2012/07/10 06:00 [entrez]
PHST- 2012/07/10 06:00 [pubmed]
PHST- 2014/03/22 06:00 [medline]
AID - das030 [pii]
AID - 10.1093/heapro/das030 [doi]
PST - ppublish
SO  - Health Promot Int. 2013 Sep;28(3):453-65. doi: 10.1093/heapro/das030. Epub 2012
      Jul 6.


PMID- 22773594
OWN - NLM
STAT- MEDLINE
DCOM- 20130129
LR  - 20120910
IS  - 1555-905X (Electronic)
IS  - 1555-9041 (Linking)
VI  - 7
IP  - 9
DP  - 2012 Sep
TI  - To dialyze or not: the patient with metastatic cancer and AKI in the intensive
      care unit.
PG  - 1507-12
LID - 10.2215/CJN.02030212 [doi]
AB  - AKI severe enough to necessitate renal replacement therapy occurs in
      approximately 5% of patients admitted to the intensive care unit (ICU) and is
      associated with in-hospital mortality in excess of 50%. Complicating factors,
      such as cancer, can increase in-hospital mortality to 85%. Intensivists often
      expect that consulted nephrologists will provide dialysis when asked to do so,
      without considering whether it is likely to benefit the patient and therefore is 
      medically and ethically appropriate. In this Attending Rounds, on the basis of
      the evidence and recommendations in Shared Decision-Making in the Appropriate
      Initiation of and Withdrawal from Dialysis, a clinical practice guideline, a case
      of anuric AKI in the ICU is presented and analyzed. Woven into the discussion are
      insights from the clinical and ethics literature on this topic, along with the
      experience of the author. This Attending Rounds presents an approach to deciding 
      when it is not appropriate to dialyze patients with AKI in the ICU.
FAU - Moss, Alvin H
AU  - Moss AH
AD  - Section of Nephrology, West Virginia University School of Medicine, and Center
      for Health Ethics and Law, Robert C. Byrd Health Sciences Center, West Virginia
      University, Morgantown, West Virginia 26506-9022, USA. amoss@hsc.wvu.edu
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20120705
PL  - United States
TA  - Clin J Am Soc Nephrol
JT  - Clinical journal of the American Society of Nephrology : CJASN
JID - 101271570
SB  - IM
MH  - Acute Kidney Injury/complications/diagnosis/*therapy
MH  - Carcinoma, Squamous Cell/*complications/secondary
MH  - Fatal Outcome
MH  - Female
MH  - Humans
MH  - *Intensive Care Units/ethics
MH  - Middle Aged
MH  - Neoplasms, Unknown Primary/*complications/pathology
MH  - *Patient Selection/ethics
MH  - Practice Guidelines as Topic
MH  - *Refusal to Treat/ethics
MH  - *Renal Dialysis/adverse effects/ethics/standards
MH  - Risk Assessment
MH  - Risk Factors
MH  - Severity of Illness Index
EDAT- 2012/07/10 06:00
MHDA- 2013/01/30 06:00
CRDT- 2012/07/10 06:00
PHST- 2012/07/10 06:00 [entrez]
PHST- 2012/07/10 06:00 [pubmed]
PHST- 2013/01/30 06:00 [medline]
AID - CJN.02030212 [pii]
AID - 10.2215/CJN.02030212 [doi]
PST - ppublish
SO  - Clin J Am Soc Nephrol. 2012 Sep;7(9):1507-12. doi: 10.2215/CJN.02030212. Epub
      2012 Jul 5.


PMID- 22773547
OWN - NLM
STAT- MEDLINE
DCOM- 20130516
LR  - 20131121
IS  - 1468-3288 (Electronic)
IS  - 0017-5749 (Linking)
VI  - 62
IP  - 4
DP  - 2013 Apr
TI  - A novel mouse model of veno-occlusive disease provides strategies to prevent
      thioguanine-induced hepatic toxicity.
PG  - 594-605
LID - 10.1136/gutjnl-2012-302274 [doi]
AB  - OBJECTIVE: The anti-leukemic drugs, azathioprine and 6-mercaptopurine (6MP), are 
      important in the treatment of inflammatory bowel disease but an alternative
      faster-acting, less-allergenic thiopurine, 6-thioguanine (6TG), can cause hepatic
      veno-occlusive disease/sinusoidal obstructive syndrome (SOS). Understanding of
      SOS has been hindered by inability to ethically perform serial liver biopsies on 
      patients and the lack of an animal model. DESIGN: Normal and C57Bl/6 mice with
      specific genes altered to elucidate mechanisms responsible for 6TG-SOS, were
      gavaged daily for upto 28d with 6TG, 6MP or methylated metabolites. Animal
      survival was monitored and at sacrifice a histological score of SOS, haematology 
      and liver biochemistry were measured. RESULTS: Only 6TG caused SOS, which was
      dose related. 6TG and to a lesser extent 6MP but not methylated metabolites were 
      associated with dose-dependent haematopoietic toxicity. SOS was not detected with
      non-lethal doses of 6TG. SOS did not occur in hypoxanthine-phosphoribosyl
      transferase-deficient C57Bl/6 mice, demonstrating that 6TG-SOS requires
      thioguanine nucleotides. Hepatic inflammation was characteristic of SOS, and
      C57Bl/6 mice deficient in P- and E-selectins on the surface of vascular
      endothelial cells showed markedly reduced SOS, demonstrating a major role for
      leukocytes recruited from blood. Split dosing of 6TG markedly attenuated SOS but 
      still effected immunosuppression and prevented spontaneous colitis in Winnie
      mice, which have a single nucleotide polymorphism mutation in Muc2. CONCLUSION:
      This novel model provides clinically relevant insights into how 6TG induces SOS, 
      and how this dangerous adverse drug reaction may be avoided by either inhibition 
      of endothelial activation or simple changes to dosing regimens of 6TG, while
      still being effective treatment for colitis.
FAU - Oancea, Iulia
AU  - Oancea I
AD  - IBD Team, Immunology Infection Inflammation Program, Mater Medical Research
      Institute, South Brisbane, Queensland, Australia.
FAU - Png, Chin Wen
AU  - Png CW
FAU - Das, Indrajit
AU  - Das I
FAU - Lourie, Rohan
AU  - Lourie R
FAU - Winkler, Ingrid G
AU  - Winkler IG
FAU - Eri, Rajaraman
AU  - Eri R
FAU - Subramaniam, Nathan
AU  - Subramaniam N
FAU - Jinnah, H A
AU  - Jinnah HA
FAU - McWhinney, Brett C
AU  - McWhinney BC
FAU - Levesque, Jean-Pierre
AU  - Levesque JP
FAU - McGuckin, Michael A
AU  - McGuckin MA
FAU - Duley, John A
AU  - Duley JA
FAU - Florin, Timothy H J
AU  - Florin TH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120707
PL  - England
TA  - Gut
JT  - Gut
JID - 2985108R
RN  - FTK8U1GZNX (Thioguanine)
SB  - IM
MH  - Animals
MH  - *Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Hepatic Veno-Occlusive Disease/*chemically induced/prevention & control
MH  - Inflammatory Bowel Diseases/drug therapy
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Statistics, Nonparametric
MH  - Survival Analysis
MH  - Thioguanine/administration & dosage/*toxicity
EDAT- 2012/07/10 06:00
MHDA- 2013/05/17 06:00
CRDT- 2012/07/10 06:00
PHST- 2012/07/10 06:00 [entrez]
PHST- 2012/07/10 06:00 [pubmed]
PHST- 2013/05/17 06:00 [medline]
AID - gutjnl-2012-302274 [pii]
AID - 10.1136/gutjnl-2012-302274 [doi]
PST - ppublish
SO  - Gut. 2013 Apr;62(4):594-605. doi: 10.1136/gutjnl-2012-302274. Epub 2012 Jul 7.


PMID- 22773496
OWN - NLM
STAT- MEDLINE
DCOM- 20121001
LR  - 20190911
IS  - 0080-6234 (Print)
IS  - 0080-6234 (Linking)
VI  - 46
IP  - 3
DP  - 2012 Jun
TI  - [The construction process of managerial profile competencies for nurse
      coordinators in the hospital field].
PG  - 727-33
LID - S0080-62342012000300027 [pii]
AB  - The objective of this study was to construct a profile of managerial
      competencies, based on the consensus of nurse coordinators in the field. This
      study was developed in a philanthropic hospital in Sao Paulo, following the
      research-action model, and included 13 nurse coordinators as participants. The
      data collection was performed using the focal group technique. Data analysis was 
      performed using the theoretical frameworks related to the working process and
      managerial competencies. The results identified the greater emphasis assigned to 
      the competencies related to the mentor, coordinator and director roles. It was,
      therefore, possible to construct a professional development plan that is based on
      competencies in the technical, ethical-political, and communicative domains, as
      well as the development of citizenship. The analysis of the managerial working
      process and the study of the competencies within the managerial environment were 
      shown to be important, because they highlighted the professionals' need to
      improve, thus fulfilling personal, professional, and organizational demands.
FAU - Manenti, Simone Alexandra
AU  - Manenti SA
AD  - Departamento de Orientacao Profissional, Escola de Enfermagem, Universidade de
      Sao Paulo, Sao Paulo, Brasil. simanenti@ig.com.br
FAU - Ciampone, Maria Helena Trench
AU  - Ciampone MH
FAU - Mira, Vera Lucia
AU  - Mira VL
FAU - Minami, Ligia Fumiko
AU  - Minami LF
FAU - Soares, Jaqueline Maria Sousa
AU  - Soares JM
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - O processo de construcao do perfil de competencias gerenciais para enfermeiros
      coordenadores de area hospitalar.
PL  - Brazil
TA  - Rev Esc Enferm USP
JT  - Revista da Escola de Enfermagem da U S P
JID - 0242726
MH  - Humans
MH  - *Nurse Administrators
MH  - Nursing/*organization & administration
MH  - *Nursing Staff, Hospital
MH  - *Personnel Administration, Hospital
MH  - *Professional Competence
EDAT- 2012/07/10 06:00
MHDA- 2012/10/02 06:00
CRDT- 2012/07/10 06:00
PHST- 2010/06/23 00:00 [received]
PHST- 2011/11/01 00:00 [accepted]
PHST- 2012/07/10 06:00 [entrez]
PHST- 2012/07/10 06:00 [pubmed]
PHST- 2012/10/02 06:00 [medline]
AID - S0080-62342012000300027 [pii]
AID - 10.1590/s0080-62342012000300027 [doi]
PST - ppublish
SO  - Rev Esc Enferm USP. 2012 Jun;46(3):727-33. doi: 10.1590/s0080-62342012000300027.


PMID- 22773480
OWN - NLM
STAT- MEDLINE
DCOM- 20121001
LR  - 20190911
IS  - 0080-6234 (Print)
IS  - 0080-6234 (Linking)
VI  - 46
IP  - 3
DP  - 2012 Jun
TI  - [The analysis of activities not performed by the nursing team regarding the
      diagnosis of ineffective breathing pattern in the elderly].
PG  - 604-11
LID - S0080-62342012000300011 [pii]
AB  - The objective of this cross-sectional, descriptive study was to identify the
      activities of the Nursing Intervention Classification considered as priorities
      for an Ineffective Breathing Pattern and not performed for elderly inpatients of 
      a teaching hospital in the state of Goias. The study participants were 43 nursing
      professionals, and data collection was performed in the period spanning October
      to December 2008, after receiving approval from the Ethics Committee. It was
      observed that among the 67 activities considered to be priorities for the
      referred diagnosis, only seven were performed by all of the participants; the
      other activities, with a varied frequency, were not performed, with the main
      reason cited being that a professional from a different area completed the
      activity. It is understood that the fact that the nursing staff does not perform 
      these activities can cause lack of complete coverage in nursing care; therefore
      there is a need for a legal apparatus to describe the activities that comprise
      professional practice exclusive to nursing personnel and those activities that
      have an interdisciplinary nature.
FAU - Cavalcante, Agueda Maria Ruiz Zimmer
AU  - Cavalcante AM
AD  - Faculdade de Enfermagem, Universidade Federal de Goias, Goiania, Brasil.
      enf_agueda@yahoo.com.br
FAU - Nakatani, Adelia Yaeko Kyosen
AU  - Nakatani AY
FAU - Bachion, Maria Marcia
AU  - Bachion MM
FAU - Garcia, Telma Ribeiro
AU  - Garcia TR
FAU - Nunes, Daniella Pires
AU  - Nunes DP
FAU - Nunes, Patricia Silva
AU  - Nunes PS
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Analise de atividades nao realizadas pela equipe de enfermagem para o diagnostico
      padrao respiratorio ineficaz em idosos.
PL  - Brazil
TA  - Rev Esc Enferm USP
JT  - Revista da Escola de Enfermagem da U S P
JID - 0242726
MH  - Adult
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - *Nursing Diagnosis
MH  - *Nursing, Team
MH  - Respiration Disorders/*diagnosis
EDAT- 2012/07/10 06:00
MHDA- 2012/10/02 06:00
CRDT- 2012/07/10 06:00
PHST- 2010/11/26 00:00 [received]
PHST- 2011/11/06 00:00 [accepted]
PHST- 2012/07/10 06:00 [entrez]
PHST- 2012/07/10 06:00 [pubmed]
PHST- 2012/10/02 06:00 [medline]
AID - S0080-62342012000300011 [pii]
AID - 10.1590/s0080-62342012000300011 [doi]
PST - ppublish
SO  - Rev Esc Enferm USP. 2012 Jun;46(3):604-11. doi: 10.1590/s0080-62342012000300011.


PMID- 22773313
OWN - NLM
STAT- MEDLINE
DCOM- 20130423
LR  - 20211021
IS  - 1568-5608 (Electronic)
IS  - 0925-4692 (Linking)
VI  - 20
IP  - 5
DP  - 2012 Oct
TI  - Some applications of pharmacogenomics and epigenetics in drug development and use
      in pursuit of personalized medicine.
PG  - 245-50
LID - 10.1007/s10787-012-0145-5 [doi]
AB  - Personalized medicine has become the most recent mantra of the pharmaceutical
      industry. While truly affordable bespoke drugs may never be totally achievable,
      pharmacogenomics and epigenetics will play significant roles in developing
      targeted therapy tailored to subpopulations of disease sufferers most likely to
      benefit. Personalized medicine is a very attractive concept, but an extremely
      difficult reality to achieve due to theoretical and practical considerations.
      Foremost among the theoretical reasons is our dearth of knowledge of individual
      physiology and metabolism, as well as the interactions of genetics and
      environment in the development of most diseases. Amongst the practical reasons,
      there is the cost of new drug development, considered to be about 800 million to 
      one billion dollars (J Health Econ 22:151-185, DiMasi et al. 2003; Health Econ
      19:130-141, Adams and Vu Brantner 2010) and the fact that many drugs now on the
      market do display reasonable efficacy in large segments of the population with
      acceptable side effects. Thus, the market for "personalized" drugs may not be
      large enough to support the costs of development. Another factor is the
      limitations put on healthcare by governments and insurance companies which
      promote the use of generics rather than the creation of new chemical entities.
      Finally, there are the social and ethical considerations of turning individual
      biology into noughts and ones with the possibility of such information becoming
      public and/or being used to constrain the way one lives or the care one receives 
      (Nat Rev Drug Discov 1:300-308, Issa 2002). That said, to the degree that
      personalized medicine does become possible, pharmacogenomics and epigenetics will
      play significant roles in drug development and use.
FAU - Powanda, M C
AU  - Powanda MC
AD  - M/P Biomedical Consultants LLC, 402 Live Oak Drive, Mill Valley, CA 94941, USA.
      powanda@mpbiomed.com
FAU - Moyer, E D
AU  - Moyer ED
LA  - eng
PT  - Journal Article
DEP - 20120707
PL  - Switzerland
TA  - Inflammopharmacology
JT  - Inflammopharmacology
JID - 9112626
SB  - IM
MH  - Drug Discovery/*methods
MH  - *Epigenomics
MH  - Humans
MH  - *Pharmacogenetics
MH  - Precision Medicine/*methods
MH  - United States
MH  - United States Food and Drug Administration
EDAT- 2012/07/10 06:00
MHDA- 2013/04/24 06:00
CRDT- 2012/07/10 06:00
PHST- 2012/03/27 00:00 [received]
PHST- 2012/06/19 00:00 [accepted]
PHST- 2012/07/10 06:00 [entrez]
PHST- 2012/07/10 06:00 [pubmed]
PHST- 2013/04/24 06:00 [medline]
AID - 10.1007/s10787-012-0145-5 [doi]
PST - ppublish
SO  - Inflammopharmacology. 2012 Oct;20(5):245-50. doi: 10.1007/s10787-012-0145-5. Epub
      2012 Jul 7.


PMID- 22773162
OWN - NLM
STAT- MEDLINE
DCOM- 20130109
LR  - 20120814
IS  - 1432-0711 (Electronic)
IS  - 0932-0067 (Linking)
VI  - 286
IP  - 3
DP  - 2012 Sep
TI  - Informed consent in clinical practice and literature overview.
PG  - 649-51
LID - 10.1007/s00404-012-2442-z [doi]
AB  - Informed consent is a legal requirement to be fulfilled before any procedure is
      carried out in clinical practice. It has wide ramification and different
      interpretations in the present healthcare system. Free and informed consent is
      required for medical treatments and procedures, except in an emergency situation 
      when informed consent cannot be obtained and there is no indication that a
      reasonable patient would refuse consent to treatment. Increasing litigations and 
      other ethical considerations have prompted us to review this subject with a
      review of literature on subject and inferences by different experts in this
      field.
FAU - Dhar, Hansa
AU  - Dhar H
AD  - Department of Obstetrics and Gynaecology, Nizwa hospital, P.O. BOX 1222, 611,
      Nizwa, Al Dakhliya Governorate, Sultanate of Oman. hansa_dinesh2011@yahoo.com
FAU - Dhar, Dinesh
AU  - Dhar D
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120707
PL  - Germany
TA  - Arch Gynecol Obstet
JT  - Archives of gynecology and obstetrics
JID - 8710213
SB  - IM
MH  - Gynecology/ethics/legislation & jurisprudence
MH  - Humans
MH  - *Informed Consent
MH  - Personal Autonomy
EDAT- 2012/07/10 06:00
MHDA- 2013/01/10 06:00
CRDT- 2012/07/10 06:00
PHST- 2012/05/18 00:00 [received]
PHST- 2012/06/18 00:00 [accepted]
PHST- 2012/07/10 06:00 [entrez]
PHST- 2012/07/10 06:00 [pubmed]
PHST- 2013/01/10 06:00 [medline]
AID - 10.1007/s00404-012-2442-z [doi]
PST - ppublish
SO  - Arch Gynecol Obstet. 2012 Sep;286(3):649-51. doi: 10.1007/s00404-012-2442-z. Epub
      2012 Jul 7.


PMID- 22772893
OWN - NLM
STAT- MEDLINE
DCOM- 20130319
LR  - 20220409
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 19
IP  - 6
DP  - 2012 Nov
TI  - Undertreatment of pain in older adults: an application of beneficence.
PG  - 800-9
LID - 10.1177/0969733012447015 [doi]
AB  - Inadequate pain control, especially in older adults, remains a significant issue 
      when caring for this population. Older adults, many of whom experience multiple
      acute and chronic conditions, are especially vulnerable to having their pain
      seriously underassessed and inadequately treated. Nurses have an ethical
      obligation to appropriately treat patients' pain. To fulfill their ethical
      obligation to relieve pain in older patients, nurses often need to advocate on
      their behalf. This article provides an overview of the persistent problem of
      undertreated pain in older adults and explores how nurses can meet this ethical
      duty through the application of Beauchamp and Childress' three principles of
      beneficence.
FAU - Denny, Dawn L
AU  - Denny DL
AD  - University of North Dakota, Whitefish, MT 59937, USA. dawn.denny@my.und.edu
FAU - Guido, Ginny W
AU  - Guido GW
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120706
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Aged
MH  - *Beneficence
MH  - Geriatric Nursing/*ethics
MH  - Humans
MH  - Nursing Assessment
MH  - Nursing Evaluation Research
MH  - Nursing Methodology Research
MH  - Pain Management/ethics/*nursing
MH  - Pain Measurement/nursing
MH  - Patient Advocacy/ethics
EDAT- 2012/07/10 06:00
MHDA- 2013/03/21 06:00
CRDT- 2012/07/10 06:00
PHST- 2012/07/10 06:00 [entrez]
PHST- 2012/07/10 06:00 [pubmed]
PHST- 2013/03/21 06:00 [medline]
AID - 0969733012447015 [pii]
AID - 10.1177/0969733012447015 [doi]
PST - ppublish
SO  - Nurs Ethics. 2012 Nov;19(6):800-9. doi: 10.1177/0969733012447015. Epub 2012 Jul
      6.


PMID- 22772609
OWN - NLM
STAT- MEDLINE
DCOM- 20130118
LR  - 20120709
IS  - 0973-3922 (Electronic)
IS  - 0378-6323 (Linking)
VI  - 78
IP  - 4
DP  - 2012 Jul-Aug
TI  - Ethics in research.
PG  - 411-3
LID - 10.4103/0378-6323.98069 [doi]
FAU - Singh, Sanjay
AU  - Singh S
LA  - eng
PT  - Editorial
PL  - United States
TA  - Indian J Dermatol Venereol Leprol
JT  - Indian journal of dermatology, venereology and leprology
JID - 7701852
SB  - IM
MH  - Authorship
MH  - Biomedical Research/*ethics
MH  - Humans
MH  - Scientific Misconduct/*ethics
EDAT- 2012/07/10 06:00
MHDA- 2013/01/19 06:00
CRDT- 2012/07/10 06:00
PHST- 2012/07/10 06:00 [entrez]
PHST- 2012/07/10 06:00 [pubmed]
PHST- 2013/01/19 06:00 [medline]
AID - ijdvl_2012_78_4_411_98069 [pii]
AID - 10.4103/0378-6323.98069 [doi]
PST - ppublish
SO  - Indian J Dermatol Venereol Leprol. 2012 Jul-Aug;78(4):411-3. doi:
      10.4103/0378-6323.98069.


PMID- 22772088
OWN - NLM
STAT- MEDLINE
DCOM- 20130304
LR  - 20171116
IS  - 1559-2030 (Electronic)
IS  - 1551-7144 (Linking)
VI  - 33
IP  - 6
DP  - 2012 Nov
TI  - A new adaptive design based on Simon's two-stage optimal design for phase II
      clinical trials.
PG  - 1255-60
LID - 10.1016/j.cct.2012.07.003 [doi]
LID - S1551-7144(12)00174-7 [pii]
AB  - Phase II clinical trials are conducted to determine whether a new agent or drug
      regimen has sufficient promise in treating cancer to merit further testing in
      larger groups of patients. Both ethical and practical considerations often
      require early termination of phase II trials if early results clearly indicate
      that the new regimen is not active or worthy of further investigation. Simon's
      two-stage designs (1989) are common methods for conducting phase II studies
      investigating new cancer therapies. Banerjee and Tsiatis (2006) proposed an
      adaptive two-stage design which allows the sample size at the second stage to
      depend on the results at the first stage. Their design is more flexible than
      Simon's, but it is somewhat counter-intuitive: as the response in the first stage
      increases, the second-stage sample size increases till a certain point and then
      abruptly becomes zero. In this paper, based on Simon's two-stage optimal design, 
      we propose a new adaptive one which depends on the first stage results using the 
      restrict conditions the conditional type I error and the conditional power.
      Comparisons are made between Banerjee and Tsiatis' results and our new adaptive
      designs.
CI  - Copyright (c) 2012. Published by Elsevier Inc.
FAU - Jin, Hua
AU  - Jin H
AD  - School of Mathematical Sciences, South China Normal University, 510631, PR China.
      jinh1@163.com
FAU - Wei, Zhen
AU  - Wei Z
LA  - eng
PT  - Journal Article
DEP - 20120706
PL  - United States
TA  - Contemp Clin Trials
JT  - Contemporary clinical trials
JID - 101242342
SB  - IM
MH  - Bias
MH  - Clinical Trials, Phase II as Topic/*methods/*statistics & numerical data
MH  - Humans
MH  - *Sample Size
EDAT- 2012/07/10 06:00
MHDA- 2013/03/05 06:00
CRDT- 2012/07/10 06:00
PHST- 2012/01/25 00:00 [received]
PHST- 2012/06/06 00:00 [revised]
PHST- 2012/07/02 00:00 [accepted]
PHST- 2012/07/10 06:00 [entrez]
PHST- 2012/07/10 06:00 [pubmed]
PHST- 2013/03/05 06:00 [medline]
AID - S1551-7144(12)00174-7 [pii]
AID - 10.1016/j.cct.2012.07.003 [doi]
PST - ppublish
SO  - Contemp Clin Trials. 2012 Nov;33(6):1255-60. doi: 10.1016/j.cct.2012.07.003. Epub
      2012 Jul 6.


PMID- 22771884
OWN - NLM
STAT- MEDLINE
DCOM- 20121129
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 264
IP  - 3
DP  - 2012 Sep
TI  - Does the measurement of the difference of resistive indexes in spleen and kidney 
      allow a selective assessment of chronic kidney injury?
PG  - 894-902
LID - 10.1148/radiol.12111533 [doi]
AB  - PURPOSE: To determine whether the difference of resistive indexes (RIs) in spleen
      and kidney (DI-RISK) is a more specific ultrasonographic (US) marker of
      intrarenal parenchymal damage than intrarenal RI alone. MATERIALS AND METHODS:
      The study was approved by the local ethics committee. All study participants
      provided informed consent. The authors defined standard values for renal RI,
      splenic RI, and DI-RISK in 152 healthy subjects; carotid intima media thickness
      (IMT) was assessed as a marker of systemic vascular disease. Next, the authors
      measured these US parameters and collected echocardiographic data in 290 patients
      with chronic kidney disease (stage 2-4) recruited between September 2008 and
      February 2011 to evaluate the DI-RISK across the spectrum of stages of kidney
      function. Correlation coefficients were calculated with the Spearman test, and
      multivariate linear regression was used to analyze independent predictors of
      renal RI, splenic RI, and DI-RISK. RESULTS: Healthy subjects had a mean age of
      34.3 years +/- 8.7, and patients with chronic kidney disease had a mean age of
      65.0 years +/- 12.3 (P < .001). In healthy subjects, both renal and splenic RIs
      were associated with IMT (renal RI: r = 0.19, P = .022; splenic RI: r = 0.23, P =
      .005); there was no correlation between DI-RISK and IMT (r = -0.10, P = .215).
      Similarly, in patients with chronic kidney disease, renal and splenic RIs
      correlated with IMT (renal RI: r = 0.33, P < .001; splenic RI: r = 0.30, P =
      .001). DI-RISK was associated with the estimated glomerular filtration rate
      (eGFR; r = -0.19, P = .001) but not with IMT (r = 0.08, P = .174). At
      multivariate regression analysis, DI-RISK was independently associated with eGFR 
      but not with extrarenal factors. CONCLUSION: In patients with chronic kidney
      disease, renal RIs do not selectively indicate organ damage, but also mirror
      systemic vascular disease. The authors introduced DI-RISK as a potential US
      marker that may more specifically reflect kidney damage.
CI  - (c) RSNA, 2012
FAU - Grun, Oliver S
AU  - Grun OS
AD  - Department of Internal Medicine IV-Nephrology and Hypertension, Saarland
      University Hospital, Kirrberger Strasse, 66421 Homburg/Saar, Germany.
FAU - Herath, Esther
AU  - Herath E
FAU - Weihrauch, Anja
AU  - Weihrauch A
FAU - Flugge, Franziska
AU  - Flugge F
FAU - Rogacev, Kyrill S
AU  - Rogacev KS
FAU - Fliser, Danilo
AU  - Fliser D
FAU - Heine, Gunnar H
AU  - Heine GH
LA  - eng
PT  - Journal Article
DEP - 20120706
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
CIN - Nat Rev Nephrol. 2012 Oct;8(10):557-8. PMID: 22926244
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Echocardiography
MH  - Female
MH  - Humans
MH  - Kidney/*blood supply/*diagnostic imaging/physiopathology
MH  - Kidney Failure, Chronic/*diagnostic imaging/*physiopathology
MH  - Kidney Function Tests
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Risk Assessment
MH  - Risk Factors
MH  - Spleen/*blood supply/*diagnostic imaging/physiopathology
MH  - Statistics, Nonparametric
MH  - Surveys and Questionnaires
MH  - *Ultrasonography, Doppler
MH  - Vascular Resistance/*physiology
EDAT- 2012/07/10 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/10 06:00
PHST- 2012/07/10 06:00 [entrez]
PHST- 2012/07/10 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - radiol.12111533 [pii]
AID - 10.1148/radiol.12111533 [doi]
PST - ppublish
SO  - Radiology. 2012 Sep;264(3):894-902. doi: 10.1148/radiol.12111533. Epub 2012 Jul
      6.


PMID- 22771883
OWN - NLM
STAT- MEDLINE
DCOM- 20121129
LR  - 20220330
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 264
IP  - 3
DP  - 2012 Sep
TI  - Visualization of hepatic uptake transporter function in healthy subjects by using
      gadoxetic acid-enhanced MR imaging.
PG  - 741-50
LID - 10.1148/radiol.12112061 [doi]
AB  - PURPOSE: To determine if genetic polymorphisms of liver-specific human organic
      anion transporting polypeptide (OATP) 1B1 and OATP1B3 influence cellular uptake
      of gadoxetic acid in vitro and if functionally relevant polymorphisms are
      confounders for liver enhancement by gadoxetic acid in healthy subjects.
      MATERIALS AND METHODS: This study received ethics approval, and all subjects
      provided written informed consent. Cellular uptake of gadoxetic acid by OATP1B1
      and OATP1B3 and their frequent genetic variants was measured by using stable
      transfected embryonic kidney HEK293 cells. Liver signal intensity at gadoxetic
      acid-enhanced MR imaging and pharmacokinetics of gadoxetic acid were evaluated in
      36 healthy carriers of SLCO1B1/1B3 wild-type alleles (n = 10), SLCO1B1*1b/*1b (n 
      = 8), SLCO1B1*15/*15 (n = 7), SLCO1B1*5/*15 (n = 1), SLCO1B1*1a/*5 (n = 6), and
      SLCO1B3*4/*4 (n = 4) by using T1-weighted MR imaging and liquid chromatography
      tandem mass spectrometry. RESULTS: Transport activity for gadoxetic acid was
      increased in cells transfected with SLCO1B1c.388A>G (12.8 pmol/[mg.min]6 3.53, P 
      = .001) but decreased in cells with SLCO1B1c.388A>G/521T>C (3.11 pmol/[mg.min]
      +/- 0.918, P = .004) compared with cells with nonvariant transporter (6.32
      pmol/[mg.min] +/- 2.73). Compared with activity of cells transfected with the
      nonvariant SLCO1B3 (7.43 pmol/[mg.min] +/- 2.43), SLCO1B3c.699G>A was a
      gain-of-function variant (15.1 pmol/[mg.min] +/- 5.52, P = .002), whereas
      SLCO1B3c.334T>G (0.364 pmol/[mg.min] +/- 0.125, P = .0001) and SLCO1B3c.1564G>T
      (0.295 pmol/[mg.min] +/- 0.247, P = .0001) were variants with lower function.
      Liver enhancement with gadoxetic acid was reduced in subjects with OATP1B1*1a/*5 
      compared with wild-type subjects and those with OATP1B1*1b/*1b (area under
      enhancement curve, 3-480 minutes in arbitrary units [au]; 20.7 au +/- 6.85 vs
      36.5 au +/- 8.08 [P = .006] vs 34.6 au +/- 8.92 [P = .026]). The OATP1B3*4
      polymorphism was not of functional relevance. No pharmacokinetic characteristics 
      of gadoxetic acid were influenced by genetic polymorphisms of OATP1B1 and
      OATP1B3. CONCLUSION: Liver-specific OATP1B1 and OATP1B3 are uptake carriers for
      gadoxetic acid in subjects. Genetic polymorphisms of OATP1B1 are signal
      confounders in gadoxetic acid-enhanced liver MR imaging.
CI  - (c) RSNA, 2012
FAU - Nassif, Ali
AU  - Nassif A
AD  - Department of Clinical Pharmacology, Ernst-Moritz-Arndt University Greifswald,
      Ferdinand-Sauerbruch-Strasse NK, Greifswald D-17475, Germany.
FAU - Jia, Jia
AU  - Jia J
FAU - Keiser, Markus
AU  - Keiser M
FAU - Oswald, Stefan
AU  - Oswald S
FAU - Modess, Christiane
AU  - Modess C
FAU - Nagel, Stefan
AU  - Nagel S
FAU - Weitschies, Werner
AU  - Weitschies W
FAU - Hosten, Norbert
AU  - Hosten N
FAU - Siegmund, Werner
AU  - Siegmund W
FAU - Kuhn, Jens-Peter
AU  - Kuhn JP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120706
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - 0 (Liver-Specific Organic Anion Transporter 1)
RN  - 0 (Organic Anion Transporters)
RN  - 0 (Organic Anion Transporters, Sodium-Independent)
RN  - 0 (SLCO1B1 protein, human)
RN  - 0 (SLCO1B3 protein, human)
RN  - 0 (Solute Carrier Organic Anion Transporter Family Member 1B3)
RN  - 0 (gadolinium ethoxybenzyl DTPA)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
CIN - Radiology. 2012 Sep;264(3):621-3. PMID: 22919034
CIN - Radiology. 2013 Apr;267(1):314-5. PMID: 23525720
CIN - Radiology. 2013 Apr;267(1):315. PMID: 23641488
MH  - Alleles
MH  - Analysis of Variance
MH  - Area Under Curve
MH  - Blotting, Western
MH  - Chromatography, Liquid
MH  - Contrast Media/*pharmacokinetics
MH  - Gadolinium DTPA/*pharmacokinetics
MH  - Genotype
MH  - Humans
MH  - Liver/*cytology/*metabolism
MH  - Liver-Specific Organic Anion Transporter 1
MH  - Magnetic Resonance Imaging/*methods
MH  - Organic Anion Transporters/*genetics
MH  - Organic Anion Transporters, Sodium-Independent/*genetics
MH  - Pharmacogenetics
MH  - *Polymorphism, Genetic
MH  - Solute Carrier Organic Anion Transporter Family Member 1B3
MH  - Tandem Mass Spectrometry
MH  - Transfection
EDAT- 2012/07/10 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/10 06:00
PHST- 2012/07/10 06:00 [entrez]
PHST- 2012/07/10 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - radiol.12112061 [pii]
AID - 10.1148/radiol.12112061 [doi]
PST - ppublish
SO  - Radiology. 2012 Sep;264(3):741-50. doi: 10.1148/radiol.12112061. Epub 2012 Jul 6.


PMID- 22771881
OWN - NLM
STAT- MEDLINE
DCOM- 20121129
LR  - 20181201
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 264
IP  - 3
DP  - 2012 Sep
TI  - Comparing the diagnostic yields of technologists and radiologists in an
      invitational colorectal cancer screening program performed with CT colonography.
PG  - 771-8
LID - 10.1148/radiol.12112486 [doi]
AB  - PURPOSE: To compare the diagnostic yields of a radiologist and trained
      technologists in the detection of advanced neoplasia within a population-based
      computed tomographic (CT) colonography screening program. MATERIALS AND METHODS: 
      Ethical approval was obtained from the Dutch Health Council, and written informed
      consent was obtained from all participants. Nine hundred eighty-two participants 
      (507 men, 475 women) underwent low-dose CT colonography after noncathartic bowel 
      preparation (iodine tagging) between July 13, 2009, and January 21, 2011. Each
      scan was evaluated by one of three experienced radiologists (>/=800 examinations)
      by using primary two-dimensional (2D) reading followed by secondary
      computer-aided detection (CAD) and by two of four trained technologists (>/=200
      examinations, with colonoscopic verification) by using primary 2D reading
      followed by three-dimensional analysis and CAD. Immediate colonoscopy was
      recommended for participants with lesions measuring at least 10 mm, and
      surveillance was recommended for participants with lesions measuring 6-9 mm.
      Consensus between technologists was achieved in case of discordant
      recommendations. Detection of advanced neoplasia (classified by a pathologist)
      was defined as a true-positive (TP) finding. Relative TP and false-positive (FP) 
      fractions were calculated along with 95% confidence intervals (CIs). RESULTS:
      Overall, 96 of the 982 participants were referred for colonoscopy and 104 were
      scheduled for surveillance. Sixty of 84 participants (71%) referred for
      colonoscopy by the radiologist had advanced neoplasia, compared with 55 of 64
      participants (86%) referred by two technologists. Both the radiologist and
      technologists detected all colorectal cancers (n = 5). The relative TP fraction
      (for technologists vs radiologist) for advanced neoplasia was 0.92 (95% CI: 0.78,
      1.07), and the relative FP fraction was 0.38 (95% CI: 0.21, 0.67). CONCLUSION:
      Two technologists serving as a primary reader of CT colonographic images can
      achieve a comparable sensitivity to that of a radiologist for the detection of
      advanced neoplasia, with far fewer FP referrals for colonoscopy.
CI  - (c) RSNA, 2012
FAU - de Haan, Margriet C
AU  - de Haan MC
AD  - Department of Radiology, Academic Medical Center, University of Amsterdam, PO Box
      22700, 1100 DE Amsterdam, the Netherlands. margrietcdehaan@gmail.com
FAU - Nio, C Yung
AU  - Nio CY
FAU - Thomeer, Maarten
AU  - Thomeer M
FAU - de Vries, Ayso H
AU  - de Vries AH
FAU - Bossuyt, Patrick M
AU  - Bossuyt PM
FAU - Kuipers, Ernst J
AU  - Kuipers EJ
FAU - Dekker, Evelien
AU  - Dekker E
FAU - Stoker, Jaap
AU  - Stoker J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120706
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
SB  - IM
CIN - Radiology. 2012 Sep;264(3):624-6. PMID: 22919035
MH  - Colonography, Computed Tomographic/*methods
MH  - Colorectal Neoplasms/*diagnostic imaging
MH  - Contrast Media
MH  - Female
MH  - Humans
MH  - Male
MH  - Mass Screening
MH  - Predictive Value of Tests
MH  - *Professional Competence
MH  - Radiographic Image Interpretation, Computer-Assisted/methods
MH  - Sensitivity and Specificity
MH  - *Technology, Radiologic
MH  - Workforce
EDAT- 2012/07/10 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/10 06:00
PHST- 2012/07/10 06:00 [entrez]
PHST- 2012/07/10 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - radiol.12112486 [pii]
AID - 10.1148/radiol.12112486 [doi]
PST - ppublish
SO  - Radiology. 2012 Sep;264(3):771-8. doi: 10.1148/radiol.12112486. Epub 2012 Jul 6.


PMID- 22771877
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20120920
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 265
IP  - 1
DP  - 2012 Oct
TI  - Repaired tetralogy of Fallot: ratio of right ventricular volume to left
      ventricular volume as a marker of right ventricular dilatation.
PG  - 78-86
AB  - PURPOSE: To compare indexed right ventricular (RV) end-diastolic volume (RVEDVi) 
      and the ratio of RV volume to left ventricular (LV) volume (RV/LV ratio) in
      prediction of significant pulmonary regurgitation (PR) after tetralogy of Fallot 
      (TOF) repair and to assess sex differences in the RV/LV ratio. MATERIALS AND
      METHODS: The ethics committee approved this retrospective single-center study,
      and patients or their parents or guardians signed written informed consent.
      RVEDVi, RV/LV ratio, and PR were measured with the use of magnetic resonance
      imaging in 155 consecutive patients with repaired TOF (mean age, 29.2
      years+/-10.9 [standard deviation]; 98 [63.2%] male and 57 [36.8%] female
      patients). PR fraction of 20% or greater was considered significant. The
      capability of the RVEDVi and that of the RV/LV ratio for prediction of
      significant PR were compared by using logistic regression analysis and receiver
      operating characteristic curve analysis. RESULTS: RVEDVi was significantly higher
      in male (162.8 mL/m2+/-50.4) than in female (138.2 mL/m2+/-37.5) patients
      (P=.001). Conversely, the RV/LV ratio was similar in both sexes (1.82+/-0.56
      [male] vs 1.69+/-0.46 [female], P=.13) both in the entire cohort and after
      excluding patients with significant (>/=30 mm Hg) RV outflow tract gradient
      and/or other residual hemodynamic abnormalities (P=.63). Receiver operating
      characteristic analysis revealed better discrimination of significant (>/=20%)
      from insignificant (<20%) PR with the use of the RV/LV ratio than with RVEDVi
      (area under the receiver operating characteristic curve, 0.937 [model 4] vs 0.849
      [model 1], P=.01). In multivariate analysis, the only independent predictor of PR
      fraction was the RV/LV ratio. CONCLUSION: The RV/LV ratio is more accurate than
      the RVEDVi in differentiation of significant from insignificant PR. After TOF
      repair, female and male patients have similar RV/LV ratios despite significant
      differences in RVEDVi between the sexes.
CI  - (c) RSNA, 2012.
FAU - Spiewak, Mateusz
AU  - Spiewak M
AD  - Department of Coronary Artery Disease and Structural Heart Diseases, Cardiac
      Magnetic Resonance Unit, Institute of Cardiology, ul Alpejska 42, 04-628 Warsaw, 
      Poland. mspiewak@ikard.pl
FAU - Malek, Lukasz A
AU  - Malek LA
FAU - Petryka, Joanna
AU  - Petryka J
FAU - Mazurkiewicz, Lukasz
AU  - Mazurkiewicz L
FAU - Werys, Konrad
AU  - Werys K
FAU - Biernacka, Elzbieta K
AU  - Biernacka EK
FAU - Kowalski, Miroslaw
AU  - Kowalski M
FAU - Hoffman, Piotr
AU  - Hoffman P
FAU - Demkow, Marcin
AU  - Demkow M
FAU - Misko, Jolanta
AU  - Misko J
FAU - Ruzyllo, Witold
AU  - Ruzyllo W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120706
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adult
MH  - Cardiac-Gated Imaging Techniques
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - Diastole/physiology
MH  - Echocardiography
MH  - Female
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Logistic Models
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Pulmonary Valve Insufficiency/*physiopathology
MH  - ROC Curve
MH  - Retrospective Studies
MH  - Sex Factors
MH  - Tetralogy of Fallot/*physiopathology/*surgery
MH  - Ventricular Dysfunction, Left/*physiopathology
MH  - Ventricular Dysfunction, Right/*physiopathology
EDAT- 2012/07/10 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/10 06:00
PHST- 2012/07/10 06:00 [entrez]
PHST- 2012/07/10 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - radiol.12120051 [pii]
AID - 10.1148/radiol.12120051 [doi]
PST - ppublish
SO  - Radiology. 2012 Oct;265(1):78-86. doi: 10.1148/radiol.12120051. Epub 2012 Jul 6.


PMID- 22770807
OWN - NLM
STAT- MEDLINE
DCOM- 20130422
LR  - 20121126
IS  - 1879-2456 (Electronic)
IS  - 0956-053X (Linking)
VI  - 32
IP  - 12
DP  - 2012 Dec
TI  - DISCRISET: a battery of tests for fast waste classification--application of tests
      on waste extracts.
PG  - 2218-28
LID - 10.1016/j.wasman.2012.05.017 [doi]
LID - S0956-053X(12)00226-7 [pii]
AB  - The Hazardous Waste Directive (HWD, Council Directive 91/689/EC, 1991) provides a
      framework for classification of hazardous waste, based on 15 Hazard (H)-criteria.
      For complex wastes the HWD foresees the application of toxicity tests on the
      waste material itself to assess its toxic properties. However, these proposed
      test methods often involve mammalian testing, which is not acceptable from an
      ethical point of view, nor is it feasible economically. The DISCRISET project was
      initiated to investigate the use of alternative chemical and biological fast
      screening tests for waste hazard classification. In the first part of the
      project, different methods were reviewed and a testing strategy was proposed to
      minimize time and cost of analysis by a tiered approach. This includes as a first
      tier chemical analysis followed by a general acute toxicity screen as a second
      tier and as a third tier mechanistic toxicity tests to assess chronic toxicity
      (genotoxicity, hormone disturbance, teratogenic effects, immunologic activity).
      In this phase of the project, selected methods were applied to 16 different waste
      samples from various sources and industries. The first tier chemical tests are
      recommended for the full characterization of the leachate fraction (inorganics)
      but not for the organic fraction of samples. Here the chemical characterization
      is only useful if toxic content is known or suspected. As second tier the fast
      bacterial test Microtox is validated as a general toxicity screen for the organic
      fraction (worst case organic extract). Samples that are not classified in tier 1 
      or 2 are then further investigated in the third tier by the mechanistic toxicity 
      tests and tested for their potential chronic toxicity: immune activity (TNF-alpha
      upregulation) is indicative for corrosive, irritating or sensitising effects
      (H4/H8/H15), reproductive effects (H10) are indicated by hormone disturbance and 
      early life stage abnormalities in fish larvae when exposed to the extracts and
      mutagenicity and carcinogenicity (H7, H11) are indicated by SOS response
      induction and increased mutation frequency in the Ames test when exposed to the
      extracts. Results indicate that the combination of chemical tests and bioassays
      allows important hazardous properties to be addressed and the tiered approach
      ensures that the tests are performed quickly and economically. The suggested
      strategy provides a solid and ethical alternative to the methods described in the
      HWD and is a vast improvement on the current, arbitrary classification.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Deprez, K
AU  - Deprez K
AD  - University of Hasselt - Biomedical Research Institute, University Hasselt, Campus
      Diepenbeek, Agoralaan C, B3590 Diepenbeek, Belgium.
FAU - Robbens, J
AU  - Robbens J
FAU - Nobels, I
AU  - Nobels I
FAU - Vanparys, C
AU  - Vanparys C
FAU - Vanermen, G
AU  - Vanermen G
FAU - Tirez, K
AU  - Tirez K
FAU - Michiels, L
AU  - Michiels L
FAU - Weltens, R
AU  - Weltens R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120704
PL  - United States
TA  - Waste Manag
JT  - Waste management (New York, N.Y.)
JID - 9884362
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hazardous Waste)
SB  - IM
MH  - Biological Assay
MH  - Environmental Pollutants/chemistry/*toxicity
MH  - Hazardous Waste/*classification
MH  - Pilot Projects
MH  - Time Factors
MH  - Toxicity Tests/*methods
EDAT- 2012/07/10 06:00
MHDA- 2013/04/23 06:00
CRDT- 2012/07/10 06:00
PHST- 2012/01/16 00:00 [received]
PHST- 2012/04/11 00:00 [revised]
PHST- 2012/05/14 00:00 [accepted]
PHST- 2012/07/10 06:00 [entrez]
PHST- 2012/07/10 06:00 [pubmed]
PHST- 2013/04/23 06:00 [medline]
AID - S0956-053X(12)00226-7 [pii]
AID - 10.1016/j.wasman.2012.05.017 [doi]
PST - ppublish
SO  - Waste Manag. 2012 Dec;32(12):2218-28. doi: 10.1016/j.wasman.2012.05.017. Epub
      2012 Jul 4.


PMID- 22769855
OWN - NLM
STAT- MEDLINE
DCOM- 20130205
LR  - 20120905
IS  - 1618-1301 (Electronic)
IS  - 0018-442X (Linking)
VI  - 63
IP  - 4
DP  - 2012 Aug
TI  - The 'Prof. Dr. Romulo Lambre' Collection: an Argentinian sample of modern
      skeletons.
PG  - 275-81
LID - 10.1016/j.jchb.2012.04.002 [doi]
AB  - This paper describes the 'Prof. Dr. Romulo Lambre' skeletal collection. The
      Lambre Collection is housed in the School of Medical Sciences of the National
      University of La Plata and it consists of skeletal remains ceded by the Municipal
      Cemetery of La Plata. The collection has more than four hundred skeletons, with
      information on age, sex, nationality, date and cause of death. It was created for
      teaching and research purposes in compliance with current legislation, and its
      management meets guidelines specified in the Declaration of the Argentinian
      Association for Biological Anthropology on Research Ethics on Human Remains
      (2007).
CI  - Copyright (c) 2012 Elsevier GmbH. All rights reserved.
FAU - Salceda, S A
AU  - Salceda SA
AD  - Catedra de Metodos y Tecnicas en la Investigacion en Antropologia Biologica,
      Facultad de Ciencias Naturales y Museo, Universidad Nacional de La Plata, Paseo
      del Bosque s/n. CP 1900, La Plata, Provincia de Buenos Aires, Argentina.
      ssalceda@fcnym.unlp.edu.ar
FAU - Desantolo, B
AU  - Desantolo B
FAU - Mancuso, R Garcia
AU  - Mancuso RG
FAU - Plischuk, M
AU  - Plischuk M
FAU - Inda, A M
AU  - Inda AM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120704
PL  - Germany
TA  - Homo
JT  - Homo : internationale Zeitschrift fur die vergleichende Forschung am Menschen
JID - 0374655
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Argentina
MH  - Biomedical Research
MH  - Child
MH  - Child, Preschool
MH  - Education, Medical
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Middle Aged
MH  - *Skeleton
MH  - *Specimen Handling
MH  - Young Adult
EDAT- 2012/07/10 06:00
MHDA- 2013/02/06 06:00
CRDT- 2012/07/10 06:00
PHST- 2011/03/12 00:00 [received]
PHST- 2012/04/23 00:00 [accepted]
PHST- 2012/07/10 06:00 [entrez]
PHST- 2012/07/10 06:00 [pubmed]
PHST- 2013/02/06 06:00 [medline]
AID - S0018-442X(12)00046-7 [pii]
AID - 10.1016/j.jchb.2012.04.002 [doi]
PST - ppublish
SO  - Homo. 2012 Aug;63(4):275-81. doi: 10.1016/j.jchb.2012.04.002. Epub 2012 Jul 4.


PMID- 22769052
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20141120
IS  - 1744-1706 (Electronic)
IS  - 1744-1692 (Linking)
VI  - 7 Suppl 1
DP  - 2012
TI  - Knowledge networks for global public health.
PG  - S73-81
LID - 10.1080/17441692.2012.693517 [doi]
AB  - The challenges posed by a globalised world have made it imperative for society to
      search for solutions to emerging issues and to develop new ways of looking at old
      problems. Current discussions about global public health demand a shift in
      paradigms and the strategic positioning of public health within broader policy
      discussions that will enable it to influence political and action agendas.
      Critical to responding to these challenges is the generation, transmission and
      dissemination of new knowledge to create value. Recognising the cutting-edge role
      of knowledge, as a new form of capital that drives innovation and transforms
      society, the formation of knowledge networks is viewed as a strategy for
      developing a shared intellectual, conceptual and ethical infrastructure for the
      field of global public health. These knowledge networks are envisioned as a
      vehicle for sharing diverse perspectives, encouraging debate and sustaining
      alternative ways of thinking about and responding to the challenges that confront
      global public health today and in the future.
FAU - Natividad, Maria Dulce F
AU  - Natividad MD
AD  - Mailman School of Public Health, Columbia University, New York, USA.
      mfn2004@columbia.edu
FAU - Fiereck, Kirk J
AU  - Fiereck KJ
FAU - Parker, Richard
AU  - Parker R
LA  - eng
PT  - Journal Article
DEP - 20120709
PL  - England
TA  - Glob Public Health
JT  - Global public health
JID - 101256323
SB  - IM
MH  - Forecasting
MH  - Global Health/ethics/*trends
MH  - Health Policy
MH  - Humans
MH  - *Knowledge
MH  - Politics
MH  - Public Health/ethics/*trends
MH  - Social Conditions
EDAT- 2012/07/10 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/10 06:00
PHST- 2012/07/10 06:00 [entrez]
PHST- 2012/07/10 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1080/17441692.2012.693517 [doi]
PST - ppublish
SO  - Glob Public Health. 2012;7 Suppl 1:S73-81. doi: 10.1080/17441692.2012.693517.
      Epub 2012 Jul 9.


PMID- 22768848
OWN - NLM
STAT- MEDLINE
DCOM- 20121217
LR  - 20211021
IS  - 1471-2318 (Electronic)
IS  - 1471-2318 (Linking)
VI  - 12
DP  - 2012 Jul 8
TI  - Occupational therapy discharge planning for older adults: a protocol for a
      randomised trial and economic evaluation.
PG  - 34
LID - 10.1186/1471-2318-12-34 [doi]
AB  - BACKGROUND: Decreased functional ability is common in older adults after
      hospitalisation. Lower levels of functional ability increase the risk of hospital
      readmission and nursing care facility admission. Discharge planning across the
      hospital and community interface is suggested to increase functional ability and 
      decrease hospital length of stay and hospital readmission. However evidence is
      limited and the benefits of occupational therapists providing this service has
      not been investigated.This randomised trial will investigate the clinical
      effectiveness of a discharge planning program in reducing functional difficulties
      of older adults post-discharge. This trial will also examine the cost of the
      intervention and cost effectiveness when compared to in-hospital discharge
      planning. METHODS/DESIGN: 400 participants admitted to participating hospitals
      will be recruited. Participants will be 70 years of age and over, have no
      significant cognitive impairment and be independently mobile at discharge. This
      study protocol was approved by the ethics committee of Ryde Rehabilitation Human 
      Research Ethics Committee, Western Sydney Local Health District (Westmead Campus)
      Human Research Ethics Committee, Alfred Health Human Research ethics committee
      for the randomised trial and NSW Population and Health Service Human Research
      Ethics Committee for data linkage. Participants will provide informed written
      consent.Participants will be randomly allocated to the intervention or control
      group. The intervention group will receive discharge planning therapies primarily
      within their home environment while the control group will receive an in-hospital
      consultation, both provided by trained occupational therapists. Primary outcome
      measures will be the Nottingham Extended Activities of Daily Living Scale (NEADL)
      and the Late Life Disability Index (LLDI) which will measure functional
      independence, and participation and limitation in daily life activities.
      DISCUSSION: This trial will investigate the effectiveness and cost effectiveness 
      of occupational therapy discharge planning in reducing functional difficulties.
      Results will have a direct impact on healthcare practice and policy. TRIAL
      REGISTRATION: ACTRN12611000615987.
FAU - Wales, Kylie
AU  - Wales K
AD  - Ageing Work and Health Research Unit, Faculty of Health Sciences, The University 
      of Sydney, NSW, Australia.
FAU - Clemson, Lindy
AU  - Clemson L
FAU - Lannin, Natasha A
AU  - Lannin NA
FAU - Cameron, Ian D
AU  - Cameron ID
FAU - Salked, Glenn
AU  - Salked G
FAU - Gitlin, Laura
AU  - Gitlin L
FAU - Rubenstein, Laurance
AU  - Rubenstein L
FAU - Barras, Sarah
AU  - Barras S
FAU - Mackenzie, Lynette
AU  - Mackenzie L
FAU - Davies, Collette
AU  - Davies C
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20120708
PL  - England
TA  - BMC Geriatr
JT  - BMC geriatrics
JID - 100968548
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cost-Benefit Analysis
MH  - Humans
MH  - Occupational Therapy/economics/*methods
MH  - *Patient Discharge/economics
MH  - Treatment Outcome
PMC - PMC3426463
EDAT- 2012/07/10 06:00
MHDA- 2012/12/18 06:00
CRDT- 2012/07/10 06:00
PHST- 2012/06/12 00:00 [received]
PHST- 2012/06/19 00:00 [accepted]
PHST- 2012/07/10 06:00 [entrez]
PHST- 2012/07/10 06:00 [pubmed]
PHST- 2012/12/18 06:00 [medline]
AID - 1471-2318-12-34 [pii]
AID - 10.1186/1471-2318-12-34 [doi]
PST - epublish
SO  - BMC Geriatr. 2012 Jul 8;12:34. doi: 10.1186/1471-2318-12-34.


PMID- 22768627
OWN - NLM
STAT- MEDLINE
DCOM- 20121204
LR  - 20191027
IS  - 0037-8046 (Print)
IS  - 0037-8046 (Linking)
VI  - 57
IP  - 1
DP  - 2012 Jan
TI  - Social work and the Uniform Accident and Sickness Policy Provision Law: a pilot
      project.
PG  - 39-48
AB  - The Uniform Accident and Sickness Policy Provision Law (UPPL) is a statute
      existing in 26 states that permits health insurance companies to deny payment for
      claims made by individuals who have sustained injuries as a result of drug or
      alcohol use. This law presents a series of complicated clinical and ethical
      dilemmas for social workers and other medical personnel. The majority of
      contributions to the national discussion regarding the UPPL have been produced by
      the medical, nursing, and policy/legal disciplines. Social work has, however,
      remained silent. It is paramount that social workers add their perspective and
      insight to this debate. This article discusses the first survey, to the authors' 
      knowledge, of social workers practicing in health care settings regarding their
      knowledge and beliefs about the UPPL.
FAU - Cochran, Gerald
AU  - Cochran G
AD  - School of Social Work, University of Texas at Austin, TX 78703, USA.
      jcochran@mail.utexas.edu
FAU - Davis, King
AU  - Davis K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Soc Work
JT  - Social work
JID - 2984852R
SB  - IM
MH  - *Accidents
MH  - Cross-Sectional Studies
MH  - Emergency Medical Services/economics
MH  - Female
MH  - *Government Regulation
MH  - Humans
MH  - Insurance, Health/legislation & jurisprudence
MH  - Insurance, Health, Reimbursement/*legislation & jurisprudence
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - *Social Work/ethics
MH  - *Substance-Related Disorders
MH  - United States
EDAT- 2012/07/10 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/10 06:00
PHST- 2012/07/10 06:00 [entrez]
PHST- 2012/07/10 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1093/sw/swr003 [doi]
PST - ppublish
SO  - Soc Work. 2012 Jan;57(1):39-48. doi: 10.1093/sw/swr003.


PMID- 22768218
OWN - NLM
STAT- MEDLINE
DCOM- 20121127
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 6
DP  - 2012
TI  - What users think about the differences between caffeine and illicit/prescription 
      stimulants for cognitive enhancement.
PG  - e40047
LID - 10.1371/journal.pone.0040047 [doi]
AB  - Pharmacological cognitive enhancement (CE) is a topic of increasing public
      awareness. In the scientific literature on student use of CE as a study aid for
      academic performance enhancement, there are high prevalence rates regarding the
      use of caffeinated substances (coffee, caffeinated drinks, caffeine tablets) but 
      remarkably lower prevalence rates regarding the use of illicit/prescription
      stimulants such as amphetamines or methylphenidate. While the literature
      considers the reasons and mechanisms for these different prevalence rates from a 
      theoretical standpoint, it lacks empirical data to account for healthy students
      who use both, caffeine and illicit/prescription stimulants, exclusively for the
      purpose of CE. Therefore, we extensively interviewed a sample of 18 healthy
      university students reporting non-medical use of caffeine as well as
      illicit/prescription stimulants for the purpose of CE in a face-to-face setting
      about their opinions regarding differences in general and morally-relevant
      differences between caffeine and stimulant use for CE. 44% of all participants
      answered that there is a general difference between the use of caffeine and
      illicit/prescription stimulants for CE, 28% did not differentiate, 28% could not 
      decide. Furthermore, 39% stated that there is a moral difference, 56% answered
      that there is no moral difference and one participant was not able to comment on 
      moral aspects. Participants came to their judgements by applying three
      dimensions: medical, ethical and legal. Weighing the medical, ethical and legal
      aspects corresponded to the students' individual preferences of substances used
      for CE. However, their views only partly depicted evidence-based medical aspects 
      and the ethical issues involved. This result shows the need for well-directed and
      differentiated information to prevent the potentially harmful use of illicit or
      prescription stimulants for CE.
FAU - Franke, Andreas G
AU  - Franke AG
AD  - Department of Psychiatry and Psychotherapy, University Medical Centre, Mainz,
      Germany. afranke@uni-mainz.de
FAU - Lieb, Klaus
AU  - Lieb K
FAU - Hildt, Elisabeth
AU  - Hildt E
LA  - eng
PT  - Journal Article
DEP - 20120629
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Illicit Drugs)
RN  - 0 (Nootropic Agents)
RN  - 0 (Prescription Drugs)
RN  - 3G6A5W338E (Caffeine)
SB  - IM
CIN - J S C Med Assoc. 2015 Mar-Apr;111(1):32. PMID: 27124986
CIN - J S C Med Assoc. 2015 Mar-Apr;111(1):32. PMID: 27124987
MH  - Adult
MH  - Behavior/drug effects/ethics
MH  - Caffeine/*pharmacology
MH  - Central Nervous System Stimulants/*pharmacology
MH  - Cognition/*drug effects
MH  - Decision Making/drug effects/ethics
MH  - Drug Users/legislation & jurisprudence/psychology/*statistics & numerical data
MH  - Female
MH  - Humans
MH  - Illicit Drugs/legislation & jurisprudence/*pharmacology
MH  - Male
MH  - Nootropic Agents/*pharmacology
MH  - Prescription Drugs/*pharmacology
MH  - Students/psychology/statistics & numerical data
MH  - Substance-Related Disorders/psychology
PMC - PMC3386931
EDAT- 2012/07/07 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/07 06:00
PHST- 2012/02/28 00:00 [received]
PHST- 2012/05/31 00:00 [accepted]
PHST- 2012/07/07 06:00 [entrez]
PHST- 2012/07/07 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1371/journal.pone.0040047 [doi]
AID - PONE-D-12-06695 [pii]
PST - ppublish
SO  - PLoS One. 2012;7(6):e40047. doi: 10.1371/journal.pone.0040047. Epub 2012 Jun 29.


PMID- 22768154
OWN - NLM
STAT- MEDLINE
DCOM- 20121127
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 6
DP  - 2012
TI  - Scaling-up of dental pulp stem cells isolated from multiple niches.
PG  - e39885
LID - 10.1371/journal.pone.0039885 [doi]
AB  - Dental pulp (DP) can be extracted from child's primary teeth (deciduous), whose
      loss occurs spontaneously by about 5 to 12 years. Thus, DP presents an easy
      accessible source of stem cells without ethical concerns. Substantial quantities 
      of stem cells of an excellent quality and at early (2-5) passages are necessary
      for clinical use, which currently is a problem for use of adult stem cells.
      Herein, DPs were cultured generating stem cells at least during six months
      through multiple mechanical transfers into a new culture dish every 3-4 days. We 
      compared stem cells isolated from the same DP before (early population, EP) and
      six months after several mechanical transfers (late population, LP). No changes, 
      in both EP and LP, were observed in morphology, expression of stem cells markers 
      (nestin, vimentin, fibronectin, SH2, SH3 and Oct3/4), chondrogenic and myogenic
      differentiation potential, even after cryopreservation. Six hours after DP
      extraction and in vitro plating, rare 5-bromo-2'-deoxyuridine (BrdU) positive
      cells were observed in pulp central part. After 72 hours, BrdU positive cells
      increased in number and were found in DP periphery, thus originating a
      multicellular population of stem cells of high purity. Multiple stem cell niches 
      were identified in different zones of DP, because abundant expression of nestin, 
      vimentin and Oct3/4 proteins was observed, while STRO-1 protein localization was 
      restricted to perivascular niche. Our finding is of importance for the future of 
      stem cell therapies, providing scaling-up of stem cells at early passages with
      minimum risk of losing their "stemness".
FAU - Lizier, Nelson F
AU  - Lizier NF
AD  - Laboratory of Genetics, Butantan Institute, Sao Paulo, SP, Brazil.
      nelson_lizier@yahoo.com.br
FAU - Kerkis, Alexandre
AU  - Kerkis A
FAU - Gomes, Cicera M
AU  - Gomes CM
FAU - Hebling, Josimeri
AU  - Hebling J
FAU - Oliveira, Camila F
AU  - Oliveira CF
FAU - Caplan, Arnold I
AU  - Caplan AI
FAU - Kerkis, Irina
AU  - Kerkis I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120629
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Biomarkers)
RN  - 0 (Culture Media)
RN  - G34N38R2N1 (Bromodeoxyuridine)
SB  - IM
MH  - Biomarkers/metabolism
MH  - Bromodeoxyuridine/metabolism
MH  - Cell Count
MH  - Cell Culture Techniques
MH  - Cell Differentiation/drug effects
MH  - Cell Proliferation/drug effects
MH  - Cell Separation/*methods
MH  - Cells, Cultured
MH  - Child
MH  - Chondrogenesis/drug effects
MH  - Culture Media/pharmacology
MH  - Dental Pulp/*cytology
MH  - Embryonic Stem Cells/cytology/drug effects/metabolism
MH  - Gene Expression Regulation/drug effects
MH  - Humans
MH  - Immunophenotyping
MH  - Mesenchymal Stem Cells/cytology/drug effects/metabolism
MH  - Muscle Development/drug effects
MH  - *Stem Cell Niche/drug effects
MH  - Stem Cells/*cytology/drug effects/metabolism/ultrastructure
MH  - Time Factors
PMC - PMC3387222
EDAT- 2012/07/07 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/07 06:00
PHST- 2012/02/28 00:00 [received]
PHST- 2012/05/28 00:00 [accepted]
PHST- 2012/07/07 06:00 [entrez]
PHST- 2012/07/07 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1371/journal.pone.0039885 [doi]
AID - PONE-D-12-06140 [pii]
PST - ppublish
SO  - PLoS One. 2012;7(6):e39885. doi: 10.1371/journal.pone.0039885. Epub 2012 Jun 29.


PMID- 22767943
OWN - NLM
STAT- MEDLINE
DCOM- 20121205
LR  - 20181201
IS  - 1440-1665 (Electronic)
IS  - 1039-8562 (Linking)
VI  - 20
IP  - 3
DP  - 2012 Jun
TI  - Patient consent to releasing confidential information is not an ethical solution.
PG  - 252
LID - 10.1177/1039856212447662 [doi]
FAU - Foulkes, Paul
AU  - Foulkes P
FAU - Randles, Jenny
AU  - Randles J
LA  - eng
PT  - Letter
PT  - Comment
PL  - England
TA  - Australas Psychiatry
JT  - Australasian psychiatry : bulletin of Royal Australian and New Zealand College of
      Psychiatrists
JID - 9613603
SB  - IM
CON - Australas Psychiatry. 2011 Dec;19(6):489-92. PMID: 22011326
MH  - Confidentiality/*ethics
MH  - Humans
MH  - National Health Programs/*ethics
MH  - *Social Responsibility
EDAT- 2012/07/07 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/07 06:00
PHST- 2012/07/07 06:00 [entrez]
PHST- 2012/07/07 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 20/3/252 [pii]
AID - 10.1177/1039856212447662 [doi]
PST - ppublish
SO  - Australas Psychiatry. 2012 Jun;20(3):252. doi: 10.1177/1039856212447662.


PMID- 22767914
OWN - NLM
STAT- MEDLINE
DCOM- 20120723
LR  - 20211021
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Linking)
VI  - 337
IP  - 6090
DP  - 2012 Jul 6
TI  - Research ethics. Paying patients for their tissue: the legacy of Henrietta Lacks.
PG  - 37-8
LID - 10.1126/science.1216888 [doi]
FAU - Truog, Robert D
AU  - Truog RD
AD  - Children's Hospital Boston, Boston, MA 02115, USA.
      robert.truog@childrens.harvard.edu
FAU - Kesselheim, Aaron S
AU  - Kesselheim AS
FAU - Joffe, Steven
AU  - Joffe S
LA  - eng
GR  - K08 HS018465/HS/AHRQ HHS/United States
GR  - UL1 RR025758/RR/NCRR NIH HHS/United States
GR  - 1 UL1 RR025758-01/RR/NCRR NIH HHS/United States
GR  - K08HS18465-01/HS/AHRQ HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
SB  - IM
CIN - Science. 2012 Sep 14;337(6100):1292. PMID: 22984048
CIN - Science. 2012 Sep 14;337(6100):1292-3; author reply 1293. PMID: 22984049
MH  - Economics
MH  - *Ethics, Research
MH  - Female
MH  - Humans
MH  - Informed Consent
MH  - Male
MH  - *Patient Rights
MH  - Policy
MH  - *Tissue Donors
PMC - PMC4256075
MID - NIHMS511441
EDAT- 2012/07/07 06:00
MHDA- 2012/07/24 06:00
CRDT- 2012/07/07 06:00
PHST- 2012/07/07 06:00 [entrez]
PHST- 2012/07/07 06:00 [pubmed]
PHST- 2012/07/24 06:00 [medline]
AID - 337/6090/37 [pii]
AID - 10.1126/science.1216888 [doi]
PST - ppublish
SO  - Science. 2012 Jul 6;337(6090):37-8. doi: 10.1126/science.1216888.


PMID- 22767904
OWN - NLM
STAT- MEDLINE
DCOM- 20120723
LR  - 20120706
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Linking)
VI  - 337
IP  - 6090
DP  - 2012 Jul 6
TI  - Scientific ethics. Fraud-detection tool could shake up psychology.
PG  - 21-2
LID - 10.1126/science.337.6090.21 [doi]
FAU - Enserink, Martin
AU  - Enserink M
LA  - eng
PT  - News
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
SB  - IM
MH  - Data Interpretation, Statistical
MH  - *Ethics, Research
MH  - *Psychology, Social
MH  - Publishing
MH  - *Scientific Misconduct
MH  - Statistics as Topic
EDAT- 2012/07/07 06:00
MHDA- 2012/07/24 06:00
CRDT- 2012/07/07 06:00
PHST- 2012/07/07 06:00 [entrez]
PHST- 2012/07/07 06:00 [pubmed]
PHST- 2012/07/24 06:00 [medline]
AID - 337/6090/21 [pii]
AID - 10.1126/science.337.6090.21 [doi]
PST - ppublish
SO  - Science. 2012 Jul 6;337(6090):21-2. doi: 10.1126/science.337.6090.21.


PMID- 22767002
OWN - NLM
STAT- MEDLINE
DCOM- 20121210
LR  - 20191112
IS  - 1678-4219 (Electronic)
IS  - 0004-2803 (Linking)
VI  - 49
IP  - 2
DP  - 2012 Apr-Jun
TI  - Mortality and complications in patients with portal hypertension who underwent
      transjugular intrahepatic portosystemic shunt (TIPS) - 12 years experience.
PG  - 143-9
LID - S0004-28032012000200009 [pii]
AB  - CONTEXT: Transjugular intrahepatic portosystemic shunt (TIPS) is the non-surgical
      treatment option with low level of morbi-mortality and possibility of
      accomplishment in patients with severe hepatic dysfunction which aims at
      decompressing the portal system treating or reducing the portal hypertension
      complications. OBJECTIVE: Outline the profile analyze global and early mortality,
      and the complications presented by cirrhotic patients who underwent TIPS for
      treatment of digestive hemorrhage by portal hypertension. METHOD: Retrospective
      study based on the data bank of cirrhotic patients' medical reports, who
      underwent TIPS for digestive hemorrhage by portal hypertension treatment who did 
      not respond to clinical endoscopic treatment, and were assisted from 1998 to 2010
      in the Liver Transplant Service at a university hospital. The study was approved 
      by the Committee of Ethics and Research. RESULTS: The sample was comprised of 72 
      (84.7%) patients, being 57 (79.2%) males, average age 47.7 years (age range from 
      16 to 85 years and SD = 13), 21 (29.2%) patients presented liver disease as cause
      excessive intake of alcoholic drinks; 21 (29.2%) contamination by hepatitis
      virus, 16 (22.2%) excessive alcohol intake associated with virus and 14 (19.4%)
      patients presented other causes. As for initial classification, 14 (20%) had
      Child-Pugh A, 33 (47.1%) Child-Pugh B and 23 (32.9%) Child-Pugh C. Initial MELD
      was obtained in 68 patients being 37 (54.4%) higher than 15 points while 31
      (45.6%) had up to 15 points. Early death occurred in 19 (26.4%). Global mortality
      occurred in 41 (60.3%). CONCLUSIONS: Mortality is directly related to clinical
      factors of patients, being Child-Pugh and MELD classifications predictors of
      mortality, with more impact in patients with Child-Pugh class C and MELD > 15.
      The complications found were similar to those described in the literature,
      although the dysfunction by stent stenosis (26.4%) was lower than in the most of 
      the studies and the encephalopathy incidence (58.3%) was higher. Probably, the
      high incidence of encephalopathy is explained by the low incidence of stenosis.
FAU - Funes, Fernanda Ribeiro
AU  - Funes FR
AD  - Faculdade de Medicina de Sao Jose do Rio Preto, Sao Jose do Rio Preto, SP,
      Brazil.
FAU - Silva, Rita de C M A da
AU  - Silva Rde C
FAU - Arroyo, Paulo Cesar Jr
AU  - Arroyo PC Jr
FAU - Duca, William Jose
AU  - Duca WJ
FAU - Silva, Adinaldo Adhemar Menezes da
AU  - Silva AA
FAU - Silva, Renato Ferreira da
AU  - Silva RF
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - Arq Gastroenterol
JT  - Arquivos de gastroenterologia
JID - 15310600R
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - Hypertension, Portal/*mortality/surgery
MH  - Male
MH  - Middle Aged
MH  - Portasystemic Shunt, Transjugular Intrahepatic/*adverse effects
MH  - Postoperative Complications/*mortality
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Young Adult
EDAT- 2012/07/07 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/07/07 06:00
PHST- 2009/09/10 00:00 [received]
PHST- 2011/11/30 00:00 [accepted]
PHST- 2012/07/07 06:00 [entrez]
PHST- 2012/07/07 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - S0004-28032012000200009 [pii]
AID - 10.1590/s0004-28032012000200009 [doi]
PST - ppublish
SO  - Arq Gastroenterol. 2012 Apr-Jun;49(2):143-9. doi:
      10.1590/s0004-28032012000200009.


PMID- 22766898
OWN - NLM
STAT- MEDLINE
DCOM- 20130906
LR  - 20211021
IS  - 1436-2813 (Electronic)
IS  - 0941-1291 (Linking)
VI  - 43
IP  - 4
DP  - 2013 Apr
TI  - Repair of small and medium size ventral hernias with a Proceed Ventral Patch: a
      single center retrospective analysis.
PG  - 381-5
LID - 10.1007/s00595-012-0245-2 [doi]
AB  - PURPOSE: Ventral hernias are common surgical targets. The Bard((R)) Ventralex
      Hernia Patch was introduced for the repair of such hernias in the early 2000s.
      Ethicon (Johnson & Johnson) introduced the Proceed Ventral Patch (PVP) in the
      late 2000s for the same indication. The effectiveness and safety of the Bard((R))
      Ventralex Hernia Patch has been proven in a series of studies. There are no
      medical studies on the PVP in humans. This study examines the effectiveness and
      safety of PVP in the closure of ventral hernias. METHOD: A single center
      retrospective analysis of patients' data was conducted. Fifty-seven patients with
      small and medium size ventral hernias were treated with patches in the period
      between May 2009 and December 2010. The charts of these patients were reviewed.
      Demographic data, diagnosis at surgery, duration of surgery, length of hospital
      stay, postoperative complications and recurrence were recorded. RESULTS:
      Fifty-seven patients were analyzed including 21 females and 36 males with a mean 
      age of 56.7 years. The diagnosis at surgery included 36 cases of umbilical
      hernia, eight cases of epigastric hernia, seven incision hernias and six
      recurrent umbilical hernias. The mean duration of surgery was 30.7 min, and the
      mean length of hospital stay was 3.3 days. Four postoperative complications (7.1 
      %) and one case of hernia recurrence (1.7 %) were recorded. CONCLUSION: Ventral
      hernia closure with PVP is safe and effective. The rates of complication and
      recurrence are comparable to those of the Bard((R)) Ventralex Hernia Patch.
FAU - Ambe, Peter
AU  - Ambe P
AD  - Department of Surgery, Heinrich-Heine University Hospital Dusseldorf, Moorenstr. 
      5, 40225 Dusseldorf, Germany. Peter.Ambe@med.uni-duesseldorf.de
FAU - Meyer, Angela
AU  - Meyer A
FAU - Kohler, Lothar
AU  - Kohler L
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20120706
PL  - Japan
TA  - Surg Today
JT  - Surgery today
JID - 9204360
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Hernia, Ventral/*surgery
MH  - Herniorrhaphy/*instrumentation/methods
MH  - Humans
MH  - Length of Stay/statistics & numerical data
MH  - Male
MH  - Middle Aged
MH  - Operative Time
MH  - Postoperative Complications/epidemiology
MH  - Recurrence
MH  - Retrospective Studies
MH  - *Surgical Mesh
MH  - Treatment Outcome
EDAT- 2012/07/07 06:00
MHDA- 2013/09/07 06:00
CRDT- 2012/07/07 06:00
PHST- 2011/09/20 00:00 [received]
PHST- 2012/01/15 00:00 [accepted]
PHST- 2012/07/07 06:00 [entrez]
PHST- 2012/07/07 06:00 [pubmed]
PHST- 2013/09/07 06:00 [medline]
AID - 10.1007/s00595-012-0245-2 [doi]
PST - ppublish
SO  - Surg Today. 2013 Apr;43(4):381-5. doi: 10.1007/s00595-012-0245-2. Epub 2012 Jul
      6.


PMID- 22766826
OWN - NLM
STAT- MEDLINE
DCOM- 20121122
LR  - 20120706
IS  - 0807-7096 (Electronic)
IS  - 0029-2001 (Linking)
VI  - 132
IP  - 12-13
DP  - 2012 Jun 26
TI  - The establishment of ethical committees for medical research.
PG  - 1486-9
LID - 10.4045/tidsskr.12.0311 [doi]
AB  - BACKGROUND: In this article we will describe the process that preceded the
      establishment of regional committees for medical research ethics in 1985. We will
      also take a look at the difficult initial period experienced by the committees in
      the eastern and southern regions. MATERIAL AND METHODS: We have examined the
      material that has been submitted to the National Archives by the Research Council
      of Norway, the Ministry of Social Affairs and the Ministry of Education and
      Research, as well as the records of the Regional Committees for Medical and
      Health Research Ethics South-East. RESULTS: From the early 1970s the Norwegian
      Medical Association played a key role, for example by launching the proposal for 
      "nationally dispersed committees" in 1977. There was widespread consensus that
      such committees were desirable, but everybody assumed that they would be funded
      by somebody else. As a result, the simplest model was chosen. The full set of
      regional committees was not established until 1987, and even more time passed
      before they were granted the funding that could ensure appropriate processing of 
      cases. This was only achieved after the adoption of the Research Ethics Act in
      2006. INTERPRETATION: Unsolved financial issues were the key reason why this
      process was so prolonged. The organisational model proposed by the Norwegian
      Medical Association in 1977 is fairly similar to the one that the Health Research
      Act brought into place in 2009.
FAU - Lahlum, Emil
AU  - Lahlum E
AD  - Regional Committees for Medical and Health Research Ethics South-East, Oslo,
      Norway. emil.lahlum@medisin.uio.no
FAU - Ruyter, Knut W
AU  - Ruyter KW
LA  - eng
LA  - nor
PT  - Historical Article
PT  - Journal Article
PL  - Norway
TA  - Tidsskr Nor Laegeforen
JT  - Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny
      raekke
JID - 0413423
SB  - IM
MH  - Biomedical Research/*ethics/history/legislation & jurisprudence
MH  - Ethics Committees, Research/economics/history/*organization & administration
MH  - Ethics, Research/history
MH  - History, 20th Century
MH  - Norway
MH  - Societies, Medical
EDAT- 2012/07/07 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/07 06:00
PHST- 2012/07/07 06:00 [entrez]
PHST- 2012/07/07 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 2503749 [pii]
AID - 10.4045/tidsskr.12.0311 [doi]
PST - ppublish
SO  - Tidsskr Nor Laegeforen. 2012 Jun 26;132(12-13):1486-9. doi:
      10.4045/tidsskr.12.0311.


PMID- 22766813
OWN - NLM
STAT- MEDLINE
DCOM- 20121122
LR  - 20130109
IS  - 0807-7096 (Electronic)
IS  - 0029-2001 (Linking)
VI  - 132
IP  - 12-13
DP  - 2012 Jun 26
TI  - [A research ethical gray area].
PG  - 1433
LID - 10.4045/tidsskr.12.0285 [doi]
FAU - Lorem, Geir
AU  - Lorem G
AD  - Institutt for helse- og omsorgsfag, Det helsevitenskapelige fakultet,
      Universitetet i Tromso, Norway.
FAU - Obstfelder, Aud
AU  - Obstfelder A
LA  - nor
PT  - Journal Article
TT  - En forskningsetisk grasone.
PL  - Norway
TA  - Tidsskr Nor Laegeforen
JT  - Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny
      raekke
JID - 0413423
SB  - IM
CIN - Tidsskr Nor Laegeforen. 2012 Nov 12;132(21):2359-60; author reply 2360. PMID:
      23160575
MH  - Biomedical Research/*ethics/legislation & jurisprudence
MH  - Ethics Committees, Research
MH  - *Ethics, Research
MH  - Humans
MH  - Norway
MH  - Qualitative Research
MH  - *Research Design/legislation & jurisprudence/standards
EDAT- 2012/07/07 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/07 06:00
PHST- 2012/07/07 06:00 [entrez]
PHST- 2012/07/07 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 2501150 [pii]
AID - 10.4045/tidsskr.12.0285 [doi]
PST - ppublish
SO  - Tidsskr Nor Laegeforen. 2012 Jun 26;132(12-13):1433. doi:
      10.4045/tidsskr.12.0285.


PMID- 22765019
OWN - NLM
STAT- MEDLINE
DCOM- 20130612
LR  - 20191210
IS  - 1532-5040 (Electronic)
IS  - 0959-3985 (Linking)
VI  - 29
IP  - 2
DP  - 2013 Feb
TI  - Ethical issues in physiotherapy--reflected from the perspective of
      physiotherapists in private practice.
PG  - 96-112
LID - 10.3109/09593985.2012.700388 [doi]
AB  - BACKGROUND: An important aspect of physiotherapy professional autonomy is the
      ethical code of the profession, both collectively and for the individual member
      of the profession. The aim of this study is to explore and add additional insight
      into the nature and scope of ethical issues as they are understood and
      experienced by Danish physiotherapists in outpatient, private practice. METHODS: 
      A qualitative approach was chosen and semi-structured interviews with 21
      physiotherapists were carried out twice and analyzed, using a phenomenological
      hermeneutic framework. RESULTS: One main theme emerged: The ideal of being
      beneficent toward the patient. Here, the ethical issues uncovered in the
      interviews were embedded in three code-groups: 1) ethical issues related to
      equality; 2) feeling obligated to do one's best; and 3) transgression of
      boundaries. CONCLUSIONS: In an ethical perspective, physiotherapy in private
      practice is on a trajectory toward increased professionalism. Physiotherapists in
      private practice have many reflections on ethics and these reflections are
      primarily based on individual common sense arguments and on deontological
      understandings. As physiotherapy by condition is characterized by asymmetrical
      power encounters where the parties are in close physical and emotional contact,
      practiced physiotherapy has many ethical issues embedded. Some physiotherapists
      meet these issues in a professional manner, but others meet them in unconscious
      or unprofessional ways. An explicit ethical consciousness among Danish
      physiotherapists in private practice seems to be needed. A debate of how to
      understand and respect the individual physiotherapist's moral versus the ethics
      of the profession needs to be addressed.
FAU - Praestegaard, Jeanette
AU  - Praestegaard J
AD  - Department of Physiotherapy Health Sciences, Health Sciences Center, Lund
      University, Lund, Sweden. j.praestegaard@oncable.dk
FAU - Gard, Gunvor
AU  - Gard G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120705
PL  - England
TA  - Physiother Theory Pract
JT  - Physiotherapy theory and practice
JID - 9015520
SB  - IM
MH  - Ambulatory Care/*ethics
MH  - Attitude of Health Personnel
MH  - Beneficence
MH  - *Codes of Ethics
MH  - Conflict, Psychological
MH  - Denmark
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Moral Obligations
MH  - Physical Therapists/*ethics/psychology
MH  - Physical Therapy Specialty/*ethics
MH  - Private Practice/*ethics
MH  - Professional Autonomy
MH  - Professional-Patient Relations/ethics
MH  - Qualitative Research
EDAT- 2012/07/07 06:00
MHDA- 2013/06/13 06:00
CRDT- 2012/07/07 06:00
PHST- 2012/07/07 06:00 [entrez]
PHST- 2012/07/07 06:00 [pubmed]
PHST- 2013/06/13 06:00 [medline]
AID - 10.3109/09593985.2012.700388 [doi]
PST - ppublish
SO  - Physiother Theory Pract. 2013 Feb;29(2):96-112. doi:
      10.3109/09593985.2012.700388. Epub 2012 Jul 5.


PMID- 22764854
OWN - NLM
STAT- MEDLINE
DCOM- 20121210
LR  - 20151119
IS  - 1536-0539 (Electronic)
IS  - 1536-0288 (Linking)
VI  - 26
IP  - 2
DP  - 2012 Jun
TI  - Off-label prescribing of medications for pain: maintaining optimal care at an
      intersection of law, public policy, and ethics.
PG  - 146-52
LID - 10.3109/15360288.2012.671243 [doi]
AB  - For more than 60 years, regulations limited marketing of medications for
      off-label uses to very low levels. Some key policy changes in the late 1990s
      ushered in an era of deregulation of off-label marketing. Policy changes included
      revised United States federal law as well as modifications of Food and Drug
      Administration (FDA) regulations. Subsequent investigations documented an
      explosion in scope off-label prescribing. Attempts to limit off-label advertising
      by manufacturers were vigorously challenged in the courts. Other modalities are
      needed to maintain a clinical care environment that places the patients' best
      interests first. In many circumstances, an off-label medication may be in the
      patient's best interests; however, where there is a lower level of clinical
      justification, the informed consent of the patient and shared decision making of 
      the patient is essential to optimize outcome.
FAU - Ruble, James
AU  - Ruble J
AD  - Department of Pharmacotherapy, University of Utah College of Pharmacy, Salt Lake 
      City, UT 84112-5820, USA. jim.ruble@hsc.utah.edu
LA  - eng
PT  - Journal Article
DEP - 20120419
PL  - England
TA  - J Pain Palliat Care Pharmacother
JT  - Journal of pain & palliative care pharmacotherapy
JID - 101125608
SB  - IM
CIN - J Pain Palliat Care Pharmacother. 2012 Jun;26(2):131-3. PMID: 22764850
MH  - Decision Making
MH  - Drug Labeling
MH  - Health Policy
MH  - Humans
MH  - Informed Consent
MH  - Off-Label Use/ethics/*legislation & jurisprudence
MH  - Pain/*drug therapy
MH  - Patient Participation
MH  - Practice Guidelines as Topic
MH  - Practice Patterns, Physicians'/ethics/legislation & jurisprudence/*standards
MH  - United States
MH  - United States Food and Drug Administration
EDAT- 2012/07/07 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/07/07 06:00
PHST- 2012/07/07 06:00 [entrez]
PHST- 2012/07/07 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - 10.3109/15360288.2012.671243 [doi]
PST - ppublish
SO  - J Pain Palliat Care Pharmacother. 2012 Jun;26(2):146-52. doi:
      10.3109/15360288.2012.671243. Epub 2012 Apr 19.


PMID- 22764850
OWN - NLM
STAT- MEDLINE
DCOM- 20121210
LR  - 20181201
IS  - 1536-0539 (Electronic)
IS  - 1536-0288 (Linking)
VI  - 26
IP  - 2
DP  - 2012 Jun
TI  - Off-label prescribing: in search of a reasonable patient-centered approach.
PG  - 131-3
LID - 10.3109/15360288.2012.679335 [doi]
AB  - This commentary relates to an article entitled "Off-Label Prescribing of
      Medications for Pain: Maintaining Optimal Care at an Intersection of Law, Public 
      Policy, and Ethics," which appears in the same journal issue. Off-label
      prescribing and off-label marketing of drugs are differentiated. Vulnerability of
      pain patients with off-label prescribing is noted as is the lack of data on
      benefits and risks of the practice. The influence of the pharmaceutical industry 
      in off-label prescribing is discussed. A lack of transparency when communicating 
      with patients about off-label drug use is a concern.
FAU - Rich, Ben A
AU  - Rich BA
AD  - University of California, Davis School of Medicine, Sacramento, CA 95817, USA.
      barich@ucdavis.edu
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - England
TA  - J Pain Palliat Care Pharmacother
JT  - Journal of pain & palliative care pharmacotherapy
JID - 101125608
SB  - IM
CON - J Pain Palliat Care Pharmacother. 2012 Jun;26(2):146-52. PMID: 22764854
MH  - Humans
MH  - Off-Label Use/*legislation & jurisprudence
MH  - Pain/*drug therapy
MH  - Practice Patterns, Physicians'/*standards
EDAT- 2012/07/07 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/07/07 06:00
PHST- 2012/07/07 06:00 [entrez]
PHST- 2012/07/07 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - 10.3109/15360288.2012.679335 [doi]
PST - ppublish
SO  - J Pain Palliat Care Pharmacother. 2012 Jun;26(2):131-3. doi:
      10.3109/15360288.2012.679335.


PMID- 22764828
OWN - NLM
STAT- MEDLINE
DCOM- 20130903
LR  - 20191210
IS  - 1365-2648 (Electronic)
IS  - 0309-2402 (Linking)
VI  - 69
IP  - 4
DP  - 2013 Apr
TI  - Authentic leadership, performance, and job satisfaction: the mediating role of
      empowerment.
PG  - 947-59
LID - 10.1111/j.1365-2648.2012.06089.x [doi]
AB  - AIM: To report a study conducted to test a model linking authentic leadership of 
      managers with nurses' perceptions of structural empowerment, performance, and job
      satisfaction. BACKGROUND: Authentic leadership has been proposed as the root
      element of effective leadership needed to build healthier work environments
      because there is special attention to the development of empowering
      leader-follower relationships. Although the influence of leadership style and
      empowerment on job satisfaction is well documented, there are few studies
      examining the influence of authentic leadership on nurses' empowerment and work
      outcomes. DESIGN: A non-experimental, predictive survey. METHOD: In 2008, a
      random sample of 600 Registered Nurses working in acute care hospitals across
      Ontario in Canada was surveyed. The final sample consisted of 280 (48% response
      rate) nurses. Variables were measured using the Authentic Leadership
      Questionnaire, Conditions of Work Effectiveness Questionnaire, Global Job
      Satisfaction Survey, and General Performance scale. The theoretical model was
      tested using structural equation modelling. RESULTS/OUTCOMES: The final model fit
      the data acceptably. Authentic leadership significantly and positively influenced
      staff nurses' structural empowerment, which in turn increased job satisfaction
      and self-rated performance. CONCLUSION: The results suggest that the more
      managers are seen as authentic, by emphasizing transparency, balanced processing,
      self-awareness and high ethical standards, the more nurses perceive they have
      access to workplace empowerment structures, are satisfied with their work, and
      report higher performance.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Wong, Carol A
AU  - Wong CA
AD  - Arthur Labatt Family School of Nursing, Faculty of Health Sciences, Health
      Sciences Addition (HSA), The University of Western Ontario, London, Ontario,
      Canada. cwong2@uwo.ca
FAU - Laschinger, Heather K S
AU  - Laschinger HK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120705
PL  - England
TA  - J Adv Nurs
JT  - Journal of advanced nursing
JID - 7609811
SB  - IM
CIN - Evid Based Nurs. 2014 Apr;17(2):55-6. PMID: 23873830
MH  - Female
MH  - Humans
MH  - *Job Satisfaction
MH  - *Leadership
MH  - Male
MH  - *Power, Psychological
EDAT- 2012/07/07 06:00
MHDA- 2013/09/04 06:00
CRDT- 2012/07/07 06:00
PHST- 2012/06/09 00:00 [accepted]
PHST- 2012/07/07 06:00 [entrez]
PHST- 2012/07/07 06:00 [pubmed]
PHST- 2013/09/04 06:00 [medline]
AID - 10.1111/j.1365-2648.2012.06089.x [doi]
PST - ppublish
SO  - J Adv Nurs. 2013 Apr;69(4):947-59. doi: 10.1111/j.1365-2648.2012.06089.x. Epub
      2012 Jul 5.


PMID- 22742618
OWN - NLM
STAT- MEDLINE
DCOM- 20130314
LR  - 20120629
IS  - 1365-3016 (Electronic)
IS  - 0269-5022 (Linking)
VI  - 26 Suppl 1
DP  - 2012 Jul
TI  - Global policy and programme guidance on maternal nutrition: what exists, the
      mechanisms for providing it, and how to improve them?
PG  - 315-25
LID - 10.1111/j.1365-3016.2012.01279.x [doi]
AB  - Undernutrition in one form or another affects the majority of women of
      reproductive age in most developing countries. However, there are few or no
      effective programmes trying to solve maternal undernutrition problems. The
      purpose of the paper is to examine global policy and programme guidance
      mechanisms for nutrition, what their content is with regard to maternal nutrition
      in particular, as well as how these might be improved. Almost all countries have 
      committed themselves politically to ensuring the right of pregnant and lactating 
      women to good nutrition through the Convention on the Elimination of all Forms of
      Discrimination Against Women. Despite this, the World Health Organization (WHO)
      has not endorsed any policy commitments with regard to maternal nutrition. The
      only policy guidance coming from the various technical departments of WHO relates
      to the control of maternal anaemia. There is no policy or programme guidance
      concerning issues of maternal thinness, weight gain during pregnancy and/or low
      birthweight prevention. Few if any countries have maternal nutrition programmes
      beyond those for maternal anaemia, and most of those are not effective. The lack 
      of importance given to maternal nutrition is related in part to a weakness of
      evidence, related to the difficulty of getting ethical clearance, as well as a
      generalised tendency to downplay the importance of those interventions found to
      be efficacious. No priority has been given to implementing existing policy and
      programme guidance for the control of maternal anaemia largely because of a lack 
      of any dedicated funding, linked to a lack of Millennium Development Goals
      indicator status. This is partly due to the poor evidence base, as well as to the
      common belief that maternal anaemia programmes were not effective, even if
      efficacious. The process of providing evidence-based policy and programme
      guidance to member states is currently being revamped and strengthened by the
      Department of Nutrition for Health and Development of WHO through the Nutrition
      Guidance Expert Advisory Group processes. How and if programme guidance, as well 
      as policy commitment for improved maternal nutrition, will be strengthened
      through the Nutrition Guidance Expert Advisory Group process is as yet unclear.
      The global movement to increase investment in programmes aimed at maternal and
      child undernutrition called Scaling Up Nutrition offers an opportunity to build
      developing country experience with efforts to improve nutrition during pregnancy 
      and lactation. All member states are being encouraged by the World Health
      Assembly to scale-up efforts to improve maternal infant and young child
      nutrition. Hopefully Ministries of Health in countries most affected by maternal 
      and child undernutrition will take leadership in the development of such plans,
      and ensure that the control of anaemia during pregnancy is given a great priority
      among these actions, as well as building programme experience with improved
      nutrition during pregnancy and lactation. For this to happen it is essential that
      donor support is assured, even if only to spearhead a few flagship countries.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Shrimpton, Roger
AU  - Shrimpton R
AD  - Department of Global Community Health and Behavioral Sciences, School of Public
      Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.
      roger.shrimpton@sapo.pt
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Paediatr Perinat Epidemiol
JT  - Paediatric and perinatal epidemiology
JID - 8709766
SB  - IM
MH  - Female
MH  - Health Promotion/*methods/organization & administration
MH  - Humans
MH  - Lactation
MH  - Malnutrition/*prevention & control
MH  - *Maternal Nutritional Physiological Phenomena
MH  - *Nutrition Policy
MH  - Nutritional Status
MH  - Patient Education as Topic/*methods
MH  - Pregnancy
MH  - World Health Organization
EDAT- 2012/07/07 06:00
MHDA- 2013/03/15 06:00
CRDT- 2012/06/30 06:00
PHST- 2012/06/30 06:00 [entrez]
PHST- 2012/07/07 06:00 [pubmed]
PHST- 2013/03/15 06:00 [medline]
AID - 10.1111/j.1365-3016.2012.01279.x [doi]
PST - ppublish
SO  - Paediatr Perinat Epidemiol. 2012 Jul;26 Suppl 1:315-25. doi:
      10.1111/j.1365-3016.2012.01279.x.


PMID- 22764284
OWN - NLM
STAT- MEDLINE
DCOM- 20120910
LR  - 20211021
IS  - 1476-1645 (Electronic)
IS  - 0002-9637 (Linking)
VI  - 87
IP  - 1
DP  - 2012 Jul
TI  - Teaching global public health in the undergraduate liberal arts: a survey of 50
      colleges.
PG  - 11-5
LID - 10.4269/ajtmh.2012.11-0571 [doi]
AB  - Undergraduate public health and global health studies are usually found at
      universities with graduate programs in the disciplines. Following the experience 
      of teaching a short course in global health within the liberal arts, we reviewed 
      global and public health offerings at 50 liberal arts colleges for the 2009-2010 
      academic year. Forty-two percent had a track, concentration, or program, and 30% 
      had global or public health student organizations. All colleges listed at least
      one course in the fields, with the highest number in the social sciences.
      However, many colleges had not coordinated them into a theme. Values of a liberal
      arts education are found in the study of global and public health: social
      responsibility, critical thinking, ethical reasoning, and knowledge of the wider 
      world. We propose identifying these programs within the undergraduate liberal
      arts as global public health. Capturing interest in global public health will
      enhance the curriculum and student experience.In this day and age, when the world
      is so fluid with regard to news and information, the knowledge that unnecessary
      deaths are occurring and that health care lags so far behind in some regions
      cannot be ignored. From the standpoint of basic human rights, suffering and
      inequity cannot be tolerated. Williams College student during a global health
      short course.
FAU - Hill, David R
AU  - Hill DR
AD  - National Travel Health Network and Centre, London, United Kingdom.
      david.hill@quinnipiac.edu
FAU - Ainsworth, Robert M
AU  - Ainsworth RM
FAU - Partap, Uttara
AU  - Partap U
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Trop Med Hyg
JT  - The American journal of tropical medicine and hygiene
JID - 0370507
SB  - IM
MH  - *Education
MH  - *Global Health
MH  - *Public Health
PMC - PMC3391034
EDAT- 2012/07/06 06:00
MHDA- 2012/09/11 06:00
CRDT- 2012/07/06 06:00
PHST- 2012/07/06 06:00 [entrez]
PHST- 2012/07/06 06:00 [pubmed]
PHST- 2012/09/11 06:00 [medline]
AID - 87/1/11 [pii]
AID - 10.4269/ajtmh.2012.11-0571 [doi]
PST - ppublish
SO  - Am J Trop Med Hyg. 2012 Jul;87(1):11-5. doi: 10.4269/ajtmh.2012.11-0571.


PMID- 22764139
OWN - NLM
STAT- MEDLINE
DCOM- 20120910
LR  - 20120705
IS  - 1524-8399 (Print)
IS  - 1524-8399 (Linking)
VI  - 13
IP  - 4
DP  - 2012 Jul
TI  - Using a comprehensive best practices approach to strengthen ethical
      health-related practice.
PG  - 431-7
LID - 10.1177/1524839912442515 [doi]
AB  - Ethical conduct plays a vital role in ensuring that issues such as health
      inequities are addressed. The Interactive Domain Model (IDM), a comprehensive
      best practices approach, provides a guiding framework to integrate ethics into
      health-related practice. Its five tenets emphasize the importance of developing
      multiple best practices to ensure sensitivity to local circumstances; taking into
      account the complex and interactive nature of the world; ensuring consistency
      between practice and key elements such as values, theories, evidence, and
      understanding the environment; engaging in ongoing critical reflection; and
      following a continuous improvement practice cycle with active participation from 
      priority populations. Ethical implications for each tenet and ways to meet the
      challenges related to acting ethically are discussed.
FAU - Kahan, Barbara
AU  - Kahan B
AD  - Kael Consulting, Regina, Saskatchewan, Canada. brkahan@gmail.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Health Promot Pract
JT  - Health promotion practice
JID - 100890609
SB  - IM
MH  - *Ethics, Professional
MH  - Health Education/*ethics
MH  - Models, Theoretical
MH  - *Practice Guidelines as Topic
MH  - Program Development
EDAT- 2012/07/06 06:00
MHDA- 2012/09/11 06:00
CRDT- 2012/07/06 06:00
PHST- 2012/07/06 06:00 [entrez]
PHST- 2012/07/06 06:00 [pubmed]
PHST- 2012/09/11 06:00 [medline]
AID - 13/4/431 [pii]
AID - 10.1177/1524839912442515 [doi]
PST - ppublish
SO  - Health Promot Pract. 2012 Jul;13(4):431-7. doi: 10.1177/1524839912442515.


PMID- 22764073
OWN - NLM
STAT- MEDLINE
DCOM- 20130516
LR  - 20151119
IS  - 1097-0258 (Electronic)
IS  - 0277-6715 (Linking)
VI  - 31
IP  - 28
DP  - 2012 Dec 10
TI  - A general approach for sample size calculation for the three-arm 'gold standard' 
      non-inferiority design.
PG  - 3579-96
LID - 10.1002/sim.5461 [doi]
AB  - In the three-arm 'gold standard' non-inferiority design, an experimental
      treatment, an active reference, and a placebo are compared. This design is
      becoming increasingly popular, and it is, whenever feasible, recommended for use 
      by regulatory guidelines. We provide a general method to calculate the required
      sample size for clinical trials performed in this design. As special cases, the
      situations of continuous, binary, and Poisson distributed outcomes are explored. 
      Taking into account the correlation structure of the involved test statistics,
      the proposed approach leads to considerable savings in sample size as compared
      with application of ad hoc methods for all three scale levels. Furthermore,
      optimal sample size allocation ratios are determined that result in markedly
      smaller total sample sizes as compared with equal assignment. As optimal
      allocation makes the active treatment groups larger than the placebo group,
      implementation of the proposed approach is also desirable from an ethical
      viewpoint.
CI  - Copyright (c) 2012 John Wiley & Sons, Ltd.
FAU - Stucke, Kathrin
AU  - Stucke K
AD  - Institute of Medical Biometry and Informatics, University of Heidelberg,
      Heidelberg, Germany.
FAU - Kieser, Meinhard
AU  - Kieser M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120704
PL  - England
TA  - Stat Med
JT  - Statistics in medicine
JID - 8215016
RN  - 0 (Antidepressive Agents)
RN  - 0 (Placebos)
RN  - 0 (Thiophenes)
RN  - 0DHU5B8D6V (Citalopram)
RN  - 9044SC542W (Duloxetine Hydrochloride)
SB  - IM
CIN - Stat Med. 2019 Mar 30;38(7):1300-1302. PMID: 30829445
MH  - Antidepressive Agents/administration & dosage/therapeutic use
MH  - Citalopram/administration & dosage/therapeutic use
MH  - Depressive Disorder, Major/drug therapy
MH  - Duloxetine Hydrochloride
MH  - Humans
MH  - Likelihood Functions
MH  - Multiple Sclerosis, Relapsing-Remitting/drug therapy
MH  - Placebos/administration & dosage
MH  - Poisson Distribution
MH  - Randomized Controlled Trials as Topic/methods/*standards/statistics & numerical
      data
MH  - *Research Design
MH  - *Sample Size
MH  - *Therapeutic Equivalency
MH  - Thiophenes/administration & dosage/therapeutic use
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2012/07/06 06:00
MHDA- 2013/05/17 06:00
CRDT- 2012/07/06 06:00
PHST- 2011/07/27 00:00 [received]
PHST- 2012/04/12 00:00 [accepted]
PHST- 2012/07/06 06:00 [entrez]
PHST- 2012/07/06 06:00 [pubmed]
PHST- 2013/05/17 06:00 [medline]
AID - 10.1002/sim.5461 [doi]
PST - ppublish
SO  - Stat Med. 2012 Dec 10;31(28):3579-96. doi: 10.1002/sim.5461. Epub 2012 Jul 4.


PMID- 22763915
OWN - NLM
STAT- MEDLINE
DCOM- 20140122
LR  - 20130807
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 3
DP  - 2013 Sep
TI  - Engineering ethics: looking back, looking forward.
PG  - 1395-404
LID - 10.1007/s11948-012-9374-7 [doi]
AB  - The eight pieces constituting this Meeting Report are summaries of presentations 
      made during a panel session at the 2011 Association for Practical and
      Professional Ethics (APPE) annual meeting held between March 3rd and 6th in
      Cincinnati. Lisa Newton organized the session and served as chair. The panel of
      eight consisted both of pioneers in the field and more recent arrivals. It
      covered a range of topics from how the field has developed to where it should be 
      going, from identification of issues needing further study to problems of
      training the next generation of engineers and engineering-ethics scholars.
FAU - Burgess, Richard A
AU  - Burgess RA
AD  - National Institute for Engineering Ethics, Lubbock, TX, USA.
FAU - Davis, Michael
AU  - Davis M
FAU - Dyrud, Marilyn A
AU  - Dyrud MA
FAU - Herkert, Joseph R
AU  - Herkert JR
FAU - Hollander, Rachelle D
AU  - Hollander RD
FAU - Newton, Lisa
AU  - Newton L
FAU - Pritchard, Michael S
AU  - Pritchard MS
FAU - Vesilind, P Aarne
AU  - Vesilind PA
LA  - eng
PT  - Journal Article
DEP - 20120705
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Congresses as Topic
MH  - Engineering/education/*ethics
MH  - *Ethics, Professional/education
MH  - *Ethics, Research/education
MH  - Humans
EDAT- 2012/07/06 06:00
MHDA- 2014/01/23 06:00
CRDT- 2012/07/06 06:00
PHST- 2012/05/22 00:00 [received]
PHST- 2012/06/11 00:00 [accepted]
PHST- 2012/07/06 06:00 [entrez]
PHST- 2012/07/06 06:00 [pubmed]
PHST- 2014/01/23 06:00 [medline]
AID - 10.1007/s11948-012-9374-7 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Sep;19(3):1395-404. doi: 10.1007/s11948-012-9374-7. Epub
      2012 Jul 5.


PMID- 22763702
OWN - NLM
STAT- MEDLINE
DCOM- 20130124
LR  - 20220317
IS  - 1432-1955 (Electronic)
IS  - 0932-0113 (Linking)
VI  - 111
IP  - 3
DP  - 2012 Sep
TI  - Blastocystis spp., Cryptosporidium spp., and Entamoeba histolytica exhibit
      similar symptomatic and epidemiological patterns in healthcare-seeking patients
      in Karachi.
PG  - 1357-68
LID - 10.1007/s00436-012-2972-0 [doi]
AB  - In this study, we collected data on the incidence of enteric parasites in
      healthcare-seeking individuals along with their symptoms to quantify the
      potential roles of factors such as age, sex, and seasonality in infection. We
      performed analysis to identify factors which could help differentiate parasitic
      infection from other causes of gastrointestinal illness in a community. The size 
      of the patient population (n = 339), patient selection methodology, collection
      methods, and statistical analysis followed approaches from similar studies in
      core clinical journals. Ethical approval was obtained from the University of
      Karachi's Ethical Review Board. Fecal specimens (n = 339) submitted by
      symptomatic patients were collected from two clinical laboratories, along with
      information about the patients' age, sex, and symptoms. We found that symptoms of
      fever, vomiting, and constipation were 100 % predictive of finding a parasitic
      infection, while diarrhea was 88 % predictive of a parasitic infection.
      Gastrointestinal parasite-positive patients reported diarrhea (~60 %), vomiting
      (~30 %), fever (~25 %) and constipation (~25 %), while parasite-negative patients
      exhibited a symptomatic profile without fever, vomiting, and constipation. The
      distribution of symptoms in parasite-positive patients remained relatively
      invariant regardless of the parasite identified. Blastocystis spp.-mono-infected 
      patients reported a similar profile to patients positive for Entamoeba
      histolytica/Entamoeba dispar and Cryptosporidium spp. Most parasitic infections
      exhibited a strong seasonal pattern, with a peak incidence in summer months.
      Infection by Blastocystis spp. was the most prevalent, and it was the only
      infection mathematically correlated to rainfall by Pearson's method. We observed 
      no increase in healthcare-seeking behavior following a stressful community event,
      namely, the attempted assassination of Benazir Bhutto in Karachi. The data
      suggest that parasitological testing would produce a high yield of positive
      results when performed on healthcare-seeking patients in Karachi in 2007 with
      symptoms of fever, vomiting, or constipation and a low yield when performed on
      patients noting only abdominal pain. Parasitological testing also produces a
      higher yield on patients seen in summer months.
FAU - Haider, Syeda Sadaf
AU  - Haider SS
AD  - Department of Microbiology, University of Karachi, Room No. 113, Karachi, 75270, 
      Pakistan. flourescentpearl@yahoo.com
FAU - Baqai, Rakhshanda
AU  - Baqai R
FAU - Qureshi, Fouad M
AU  - Qureshi FM
FAU - Boorom, Kenneth
AU  - Boorom K
LA  - eng
PT  - Journal Article
DEP - 20120705
PL  - Germany
TA  - Parasitol Res
JT  - Parasitology research
JID - 8703571
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Blastocystis
MH  - Blastocystis Infections/*diagnosis/epidemiology/pathology
MH  - Child
MH  - Child, Preschool
MH  - Cryptosporidiosis/*diagnosis/epidemiology/pathology
MH  - Cryptosporidium
MH  - Entamoeba
MH  - Entamoebiasis/*diagnosis/epidemiology/pathology
MH  - Feces/parasitology
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Middle Aged
MH  - Pakistan/epidemiology
MH  - Young Adult
EDAT- 2012/07/06 06:00
MHDA- 2013/01/25 06:00
CRDT- 2012/07/06 06:00
PHST- 2011/12/30 00:00 [received]
PHST- 2012/05/15 00:00 [accepted]
PHST- 2012/07/06 06:00 [entrez]
PHST- 2012/07/06 06:00 [pubmed]
PHST- 2013/01/25 06:00 [medline]
AID - 10.1007/s00436-012-2972-0 [doi]
PST - ppublish
SO  - Parasitol Res. 2012 Sep;111(3):1357-68. doi: 10.1007/s00436-012-2972-0. Epub 2012
      Jul 5.


PMID- 22763485
OWN - NLM
STAT- MEDLINE
DCOM- 20130906
LR  - 20211021
IS  - 1348-4214 (Electronic)
IS  - 0916-9636 (Linking)
VI  - 35
IP  - 11
DP  - 2012 Nov
TI  - The International Database of HOme blood pressure in relation to Cardiovascular
      Outcome (IDHOCO): moving from baseline characteristics to research perspectives.
PG  - 1072-9
LID - 10.1038/hr.2012.97 [doi]
AB  - The objective of this study is to construct an International Database of HOme
      blood pressure in relation to Cardiovascular Outcome (IDHOCO). The main goal of
      this database is to determine outcome-based diagnostic thresholds for the
      self-measured home blood pressure (BP). Secondary objectives include
      investigating the predictive value of white-coat and masked hypertension, morning
      and evening BP, BP and heart rate variability, and the home arterial stiffness
      index. We also aim to determine an optimal schedule for home BP measurements that
      provides the most accurate risk stratification. Eligible studies are
      population-based, have fatal as well as nonfatal outcomes available for analysis,
      comply with ethical standards, and have been previously published in
      peer-reviewed journals. In a meta-analysis based on individual subject data,
      composite and cause-specific cardiovascular events will be related to various
      indexes derived by home BP measurement. The analyses will be stratified by a
      cohort and adjusted for the clinic BP and established cardiovascular risk
      factors. The database includes 6753 subjects from five cohorts recruited in
      Ohasama, Japan (n=2777); Finland (n=2075); Tsurugaya, Japan (n=836); Didima,
      Greece (n=665); and Montevideo, Uruguay (n=400). In these five cohorts, during a 
      total of 62 106 person-years of follow-up (mean 9.2 years), 852 subjects died and
      740 participants experienced a fatal or nonfatal cardiovascular event. IDHOCO
      provides a unique opportunity to investigate several hypotheses that could not
      reliably be studied in individual studies. The results of these analyses should
      be of help to clinicians involved in the management of patients with suspected or
      established hypertension.
FAU - Niiranen, Teemu J
AU  - Niiranen TJ
AD  - Department of Chronic Disease Prevention, Population Studies Unit, National
      Institute for Health and Welfare, Turku, Finland.
FAU - Thijs, Lutgarde
AU  - Thijs L
FAU - Asayama, Kei
AU  - Asayama K
FAU - Johansson, Jouni K
AU  - Johansson JK
FAU - Ohkubo, Takayoshi
AU  - Ohkubo T
FAU - Kikuya, Masahiro
AU  - Kikuya M
FAU - Boggia, Jose
AU  - Boggia J
FAU - Hozawa, Atsushi
AU  - Hozawa A
FAU - Sandoya, Edgardo
AU  - Sandoya E
FAU - Stergiou, George S
AU  - Stergiou GS
FAU - Tsuji, Ichiro
AU  - Tsuji I
FAU - Jula, Antti M
AU  - Jula AM
FAU - Imai, Yutaka
AU  - Imai Y
FAU - Staessen, Jan A
AU  - Staessen JA
CN  - IDHOCO Investigators
LA  - eng
GR  - 294713/ERC_/European Research Council/International
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20120705
PL  - England
TA  - Hypertens Res
JT  - Hypertension research : official journal of the Japanese Society of Hypertension
JID - 9307690
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Pressure/*physiology
MH  - Blood Pressure Monitoring, Ambulatory/*trends
MH  - Cardiovascular Diseases/*epidemiology/physiopathology
MH  - Circadian Rhythm/physiology
MH  - Cohort Studies
MH  - Databases, Factual/*trends
MH  - Female
MH  - Finland
MH  - Follow-Up Studies
MH  - Greece
MH  - Heart Rate/physiology
MH  - Humans
MH  - Hypertension/complications/*diagnosis/physiopathology
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Prospective Studies
MH  - Risk Factors
MH  - Uruguay
MH  - White Coat Hypertension/complications/*diagnosis/physiopathology
PMC - PMC3606707
MID - EMS52457
OID - NLM: EMS52457
IR  - Asayama K
FIR - Asayama, K
IR  - Ohkubo T
FIR - Ohkubo, T
IR  - Kikuya M
FIR - Kikuya, M
IR  - Inoue R
FIR - Inoue, R
IR  - Satoh M
FIR - Satoh, M
IR  - Hosaka M
FIR - Hosaka, M
IR  - Utsugi MT
FIR - Utsugi, M T
IR  - Hirose T
FIR - Hirose, T
IR  - Hara A
FIR - Hara, A
IR  - Fukushima N
FIR - Fukushima, N
IR  - Obara T
FIR - Obara, T
IR  - Metoki H
FIR - Metoki, H
IR  - Imai Y
FIR - Imai, Y
IR  - Niiranen T
FIR - Niiranen, T
IR  - Johansson J
FIR - Johansson, J
IR  - Hanninen MR
FIR - Hanninen, M R
IR  - Reunanen A
FIR - Reunanen, A
IR  - Jula A
FIR - Jula, A
IR  - Ohmori-Matsuda K
FIR - Ohmori-Matsuda, K
IR  - Kuriyama S
FIR - Kuriyama, S
IR  - Kakizaki M
FIR - Kakizaki, M
IR  - Hozawa A
FIR - Hozawa, A
IR  - Tsuji I
FIR - Tsuji, I
IR  - Stergiou G
FIR - Stergiou, G
IR  - Boggia J
FIR - Boggia, J
IR  - Sandoya E
FIR - Sandoya, E
EDAT- 2012/07/06 06:00
MHDA- 2013/09/07 06:00
CRDT- 2012/07/06 06:00
PHST- 2012/07/06 06:00 [entrez]
PHST- 2012/07/06 06:00 [pubmed]
PHST- 2013/09/07 06:00 [medline]
AID - hr201297 [pii]
AID - 10.1038/hr.2012.97 [doi]
PST - ppublish
SO  - Hypertens Res. 2012 Nov;35(11):1072-9. doi: 10.1038/hr.2012.97. Epub 2012 Jul 5.


PMID- 22763004
OWN - NLM
STAT- MEDLINE
DCOM- 20130104
LR  - 20181201
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 10
DP  - 2012 Oct
TI  - Whose ethics of knowledge? Taking the next step in evaluating knowledge in
      synthetic biology: a response to Douglas and Savulescu.
PG  - 636-8
AB  - The recent proposal by Douglas and Savulescu for an ethics of knowledge provokes 
      a renewed consideration of an enduring issue. Yet, the concept raises significant
      challenges for procedural and substantive justice. Indeed, the operationalisation
      of 'an ethics of knowledge' could be as alarming as what it seeks to prevent.
      While we can acknowledge that there is, and surely always will be, potential for 
      misuse of beneficial science and technology, a contemplated conception of what we
      ought to not know, devise or disseminate sets before us an enormously complex
      task. This essay challenges an ethics of knowledge to respond to concerns of
      procedural and substantive justice. While the concept has a certain appeal, it
      does not appear to adequately address certain fundamental issues as it is
      currently presented. Here, the author invites consideration of two primary
      points: (1) who should decide, based on whose interests? and (2) could such an
      exercise actually be effective in achieving its goal?
FAU - Pierce, Robin L
AU  - Pierce RL
AD  - Biotechnology and Society, Department of Biotechnology, Delft University of
      Technology, Julianalaan 67, Delft 2628 BC, The Netherlands.
      pierce7@post.harvard.edu
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20120704
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
CON - J Med Ethics. 2010 Nov;36(11):687-93. PMID: 20935316
MH  - *Bioethical Issues
MH  - Biotechnology/*ethics
MH  - Humans
MH  - *Knowledge
EDAT- 2012/07/06 06:00
MHDA- 2013/01/05 06:00
CRDT- 2012/07/06 06:00
PHST- 2012/07/06 06:00 [entrez]
PHST- 2012/07/06 06:00 [pubmed]
PHST- 2013/01/05 06:00 [medline]
AID - medethics-2012-100563 [pii]
AID - 10.1136/medethics-2012-100563 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Oct;38(10):636-8. doi: 10.1136/medethics-2012-100563. Epub
      2012 Jul 4.


PMID- 22762966
OWN - NLM
STAT- MEDLINE
DCOM- 20130121
LR  - 20211021
IS  - 1873-6513 (Electronic)
IS  - 0885-3924 (Linking)
VI  - 44
IP  - 3
DP  - 2012 Sep
TI  - Dignity in end-of-life care: results of a national survey of U.S. physicians.
PG  - 331-9
LID - 10.1016/j.jpainsymman.2011.09.020 [doi]
AB  - CONTEXT: Debates persist about the relevance of "dignity" as an ethical concept
      in U.S. health care, especially in end-of-life care. OBJECTIVES: To describe the 
      attitudes and beliefs regarding the usefulness and meaning of the concept of
      dignity and to examine judgments about a clinical scenario in which dignity might
      be relevant. METHODS: Two thousand practicing U.S. physicians, from all
      specialties, were mailed a survey. Main measures included physicians' judgments
      about an end-of-life clinical scenario (criterion variable), attitudes about the 
      concept of dignity (predictors), and their religious characteristics
      (predictors). RESULTS: Responses were received from 1032 eligible physicians
      (54%). Nine (90%) of 10 physicians reported that dignity was relevant to their
      practice. After controlling for age, gender, region, and specialty, physicians
      who judged that the case patient had either some dignity or full dignity, and who
      agreed that dignity is given by a creator, were all positively associated with
      believing that the patient's life was worth living (odds ratio [OR] 10.2, 95%
      confidence interval [CI] 5.8-17.8, OR 20.5, 95% CI 11.4-36.8, OR 4.7, 95% CI
      3.1-7.0, respectively). Respondents who strongly agreed that "all living humans
      have the same amount of dignity" were also more likely to believe that the
      patient's life was worth living (OR 1.8, 95% CI 1.2-2.7). Religious
      characteristics also were associated with believing that the case patient's life 
      was worth living (OR 4.1, 95% CI 2.4-7.2, OR 3.2, 95% CI 1.6-6.3, OR 9.2, 95% CI 
      4.3-19.5, respectively). CONCLUSION: U.S. physicians view the concept of dignity 
      as useful. Those views are associated with their judgments about common
      end-of-life scenarios in which dignity concepts may be relevant.
CI  - Copyright (c) 2012 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. 
      All rights reserved.
FAU - Antiel, Ryan M
AU  - Antiel RM
AD  - Department of General Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA.
      Antiel.ryan@mayo.edu
FAU - Curlin, Farr A
AU  - Curlin FA
FAU - James, Katherine M
AU  - James KM
FAU - Sulmasy, Daniel P
AU  - Sulmasy DP
FAU - Tilburt, Jon C
AU  - Tilburt JC
LA  - eng
GR  - KL2 RR024151/RR/NCRR NIH HHS/United States
GR  - 1 KL2 RR024151/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120703
PL  - United States
TA  - J Pain Symptom Manage
JT  - Journal of pain and symptom management
JID - 8605836
SB  - IM
MH  - Adult
MH  - Aged
MH  - Attitude of Health Personnel
MH  - Attitude to Death
MH  - Female
MH  - Health Care Surveys
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Physicians
MH  - Religion
MH  - *Right to Die
MH  - Terminal Care/*ethics/statistics & numerical data
MH  - United States
PMC - PMC3967404
MID - NIHMS552530
EDAT- 2012/07/06 06:00
MHDA- 2013/01/23 06:00
CRDT- 2012/07/06 06:00
PHST- 2011/06/22 00:00 [received]
PHST- 2011/09/10 00:00 [revised]
PHST- 2011/09/15 00:00 [accepted]
PHST- 2012/07/06 06:00 [entrez]
PHST- 2012/07/06 06:00 [pubmed]
PHST- 2013/01/23 06:00 [medline]
AID - S0885-3924(12)00167-4 [pii]
AID - 10.1016/j.jpainsymman.2011.09.020 [doi]
PST - ppublish
SO  - J Pain Symptom Manage. 2012 Sep;44(3):331-9. doi:
      10.1016/j.jpainsymman.2011.09.020. Epub 2012 Jul 3.


PMID- 22762841
OWN - NLM
STAT- MEDLINE
DCOM- 20130122
LR  - 20120904
IS  - 1872-7654 (Electronic)
IS  - 0301-2115 (Linking)
VI  - 164
IP  - 1
DP  - 2012 Sep
TI  - The prevalence of probable overactive bladder, associated risk factors and its
      effect on quality of life among Turkish midwifery students.
PG  - 105-9
LID - 10.1016/j.ejogrb.2012.06.006 [doi]
AB  - OBJECTIVES: To evaluate the associated risk factors of probable overactive
      bladder (OAB) and to determine the effect of OAB on quality of life through
      validated questionnaires in Turkish midwifery students. STUDY DESIGN: 279
      midwifery students were invited to participate, and 265 (95.0%) were included in 
      the study, which was approved by the local ethics committees. The relationship
      between quality of life and probable OAB was evaluated using Turkish
      language-validated questionnaires (OABq SF, NQOL). Chi-square test, t-test and
      logistic regression were used for the statistical analysis, and p<0.05 was
      considered significant. RESULTS: The participants' mean age was 21.74 +/- 2.15
      years. The prevalence of OAB was 35.4%. There was a significant relationship
      between the presence of probable OAB and familial urinary incontinence history
      and childhood nocturnal enuresis. In the logistic regression analysis, family
      history was associated with an OR of 2.11 (95% CI: 1.08-4.10) for OAB, and
      nocturia with an OR of 2.69 (95% CI: 1.16-6.21) for OAB. Drinking moderate
      amounts of tea and carbonated drinks daily did not affect OAB, but extreme
      consumption of these beverages was associated with an OR of 2.98 (95% CI:
      1.26-7.03) for OAB. OAB significantly worsens quality of life according to all
      the quality of life indices. CONCLUSION: OAB is not a rare condition among young 
      people. It appears that the quality of life was adversely influenced by OAB among
      both younger and older people. Familial urinary incontinence and childhood
      nocturnal enuresis were found to be risk factors for OAB. There is insufficient
      evidence to restrict tea or carbonated drinks consumption in young people with
      OAB unless their consumption is extreme.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Ozgur Yeniel, A
AU  - Ozgur Yeniel A
AD  - Ege University Faculty of Medicine, Department of Obstetrics and Gynecology,
      TR-35100 Izmir, Turkey. drayeniel@hotmail.com
FAU - Mete Ergenoglu, A
AU  - Mete Ergenoglu A
FAU - Meseri, Reci
AU  - Meseri R
FAU - Hadimli, Aytul
AU  - Hadimli A
FAU - Askar, Niyazi
AU  - Askar N
FAU - Mete Itil, Ismail
AU  - Mete Itil I
LA  - eng
PT  - Journal Article
DEP - 20120703
PL  - Ireland
TA  - Eur J Obstet Gynecol Reprod Biol
JT  - European journal of obstetrics, gynecology, and reproductive biology
JID - 0375672
RN  - 0 (Tea)
SB  - IM
MH  - Carbonated Beverages/*adverse effects
MH  - Female
MH  - Humans
MH  - Midwifery/education
MH  - Nocturia/complications
MH  - Prevalence
MH  - Quality of Life
MH  - Risk Factors
MH  - Tea/*adverse effects
MH  - Turkey/epidemiology
MH  - Urinary Bladder, Overactive/*epidemiology
MH  - Urinary Incontinence/*epidemiology
MH  - Young Adult
EDAT- 2012/07/06 06:00
MHDA- 2013/01/23 06:00
CRDT- 2012/07/06 06:00
PHST- 2011/12/31 00:00 [received]
PHST- 2012/05/18 00:00 [revised]
PHST- 2012/06/08 00:00 [accepted]
PHST- 2012/07/06 06:00 [entrez]
PHST- 2012/07/06 06:00 [pubmed]
PHST- 2013/01/23 06:00 [medline]
AID - S0301-2115(12)00273-4 [pii]
AID - 10.1016/j.ejogrb.2012.06.006 [doi]
PST - ppublish
SO  - Eur J Obstet Gynecol Reprod Biol. 2012 Sep;164(1):105-9. doi:
      10.1016/j.ejogrb.2012.06.006. Epub 2012 Jul 3.


PMID- 22762514
OWN - NLM
STAT- MEDLINE
DCOM- 20130425
LR  - 20151119
IS  - 1742-7843 (Electronic)
IS  - 1742-7835 (Linking)
VI  - 111
IP  - 6
DP  - 2012 Dec
TI  - Delayed neurological complications of sulphur mustard and tabun poisoning in 43
      Iranian veterans.
PG  - 426-32
LID - 10.1111/j.1742-7843.2012.00922.x [doi]
AB  - Delayed neurotoxic complications of chemical warfare agents (CWA), such as
      sulphur mustard (SM) and tabun, in human beings have not been reported in detail.
      We thus aimed to investigate possible neurotoxic complications of these agents in
      Iranian veterans 22-27 years after exposure. After co-ordination with the veteran
      foundation and obtaining the approval of the medical research ethics committee,
      43 Iranian veterans with late complications of CWA exposure during the Iran-Iraq 
      conflict were studied after obtaining signed written informed consent.
      Demographic and clinical findings were recorded on pre-designed forms.
      Neurological examination was performed by a neurologist. Routine biochemical
      tests were performed for all the patients. Electromyography (EMG), nerve
      conduction velocity (NCV) and electroencephalography (EEG) were carried out as
      clinically indicated. The majority of the patients (38) had been exposed to SM
      and only five patients to tabun. Hyperaesthesia was the most objective finding
      (72.1%). Fatigue (93%), paraesthesia (88.3%) and headache (83.7%) were the most
      common subjective findings in the patients. Sensory nerve impairments, including 
      paraesthesia (88.3%), hyperaesthesia (72.1%) and hypoesthesia (11.6%), were the
      most common observed clinical complications. EMG and NCV were impaired in seven
      patients (16.3%) who were all SM-exposed patients but did not show any
      significant correlation with organ complications. EEG was negative even in the
      seized patients. Cholesterol, LDL and triglyceride levels were significantly
      above the normal ranges. Late neurological complications of CWA, particularly SM 
      poisoning, are considerable even after three decades of exposure and require
      medical attention.
CI  - (c) 2012 The Authors Basic & Clinical Pharmacology & Toxicology (c) 2012 Nordic
      Pharmacological Society.
FAU - Darchini-Maragheh, Emadodin
AU  - Darchini-Maragheh E
AD  - Medical Toxicology Research Center, School of Medicine, Mashhad University of
      Medical Sciences, Mashhad, Iran.
FAU - Nemati-Karimooy, Habibollah
AU  - Nemati-Karimooy H
FAU - Hasanabadi, Hosein
AU  - Hasanabadi H
FAU - Balali-Mood, Mahdi
AU  - Balali-Mood M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120803
PL  - England
TA  - Basic Clin Pharmacol Toxicol
JT  - Basic & clinical pharmacology & toxicology
JID - 101208422
RN  - 0 (Chemical Warfare Agents)
RN  - 0 (Organophosphates)
RN  - S45M750QSH (tabun)
RN  - T8KEC9FH9P (Mustard Gas)
SB  - IM
MH  - Adult
MH  - Chemical Warfare Agents/*poisoning
MH  - Cross-Sectional Studies
MH  - Electrophysiological Phenomena
MH  - Humans
MH  - Iran
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Mustard Gas/*poisoning
MH  - Nervous System Diseases/chemically induced/*physiopathology
MH  - Organophosphates/*toxicity
MH  - Time Factors
MH  - *Veterans
EDAT- 2012/07/06 06:00
MHDA- 2013/04/26 06:00
CRDT- 2012/07/06 06:00
PHST- 2012/02/26 00:00 [received]
PHST- 2012/06/15 00:00 [accepted]
PHST- 2012/07/06 06:00 [entrez]
PHST- 2012/07/06 06:00 [pubmed]
PHST- 2013/04/26 06:00 [medline]
AID - 10.1111/j.1742-7843.2012.00922.x [doi]
PST - ppublish
SO  - Basic Clin Pharmacol Toxicol. 2012 Dec;111(6):426-32. doi:
      10.1111/j.1742-7843.2012.00922.x. Epub 2012 Aug 3.


PMID- 22762502
OWN - NLM
STAT- MEDLINE
DCOM- 20141124
LR  - 20140414
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 28
IP  - 4
DP  - 2014 May
TI  - A proposed approach to informed consent for biobanks in China.
PG  - 181-6
LID - 10.1111/j.1467-8519.2012.01985.x [doi]
AB  - Biobanks are potential goldmines for genomics research. They have become
      increasingly common as a means to determine the relationship between lifestyle,
      environmental exposures and predisposition to genetic disease. More and more
      countries are developing massive national scale biobanks, including Iceland, the 
      UK and Estonia. Now several large-scale regional and national biobanks are
      planned in China, such as Shanghai Biobank, which is defined as a key-element in 
      Shanghai's twelfth five-year Development Plan of Science and Technology. It is
      imperative that the authors who are in charge of the ethical aspect of Shanghai
      Biobank discuss the ethical aspects of these biobanks up front. Currently there
      is a great deal of heterogeneity in the approaches to informed consent taken by
      different countries. In the article, after briefly introducing the biobanks in
      China, we focus on the three most common approaches: classical informed consent, 
      tiered consent, and one-time general (or blanket) consent, and propose a version 
      of the latter for China, based on compelling arguments.
CI  - (c) 2012 John Wiley & Sons Ltd.
FAU - Liu, Min
AU  - Liu M
AD  - Shanghai Clinical Research Center Independent Ethics Committee in Shanghai
      Clinical Research Center, International Bioethics Committee, UNESCO.
FAU - Hu, Qingli
AU  - Hu Q
LA  - eng
PT  - Journal Article
DEP - 20120705
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Biological Specimen Banks/*ethics
MH  - Biomedical Research/*ethics
MH  - China
MH  - *Confidentiality
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Public Opinion
MH  - Public Policy
OTO - NOTNLM
OT  - biobank
OT  - informed consent
OT  - one time general consent
OT  - opt out
EDAT- 2012/07/06 06:00
MHDA- 2014/12/15 06:00
CRDT- 2012/07/06 06:00
PHST- 2012/07/06 06:00 [entrez]
PHST- 2012/07/06 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - 10.1111/j.1467-8519.2012.01985.x [doi]
PST - ppublish
SO  - Bioethics. 2014 May;28(4):181-6. doi: 10.1111/j.1467-8519.2012.01985.x. Epub 2012
      Jul 5.


PMID- 22762392
OWN - NLM
STAT- MEDLINE
DCOM- 20141124
LR  - 20140304
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 28
IP  - 3
DP  - 2014 Mar
TI  - The nocebo effect of informed consent.
PG  - 147-54
LID - 10.1111/j.1467-8519.2012.01983.x [doi]
AB  - The nocebo effect, the mirror-phenomenon to the placebo effect, is when the
      expectation of a negative outcome precipitates the corresponding symptom or leads
      to its exacerbation. One of the basic ethical duties in health care is to obtain 
      informed consent from patients before treatment; however, the disclosure of
      information regarding potential complications or side effects that this involves 
      may precipitate a nocebo effect. While dilemmas between the principles of respect
      for patient autonomy and of nonmaleficence are recognized in medical ethics,
      there has not yet been an ethical discussion focused on the potential dilemma
      raised by the nocebo effect of informed consent (NEIC). This dilemma is
      especially pernicious, since it involves a direct causality of harm by the
      caregiver that is unparalleled by other potential harmful effects of information 
      disclosure. This paper articulates the dilemma of the NEIC and offers a seminal
      ethical analysis.
CI  - (c) 2012 John Wiley & Sons Ltd.
FAU - Cohen, Shlomo
AU  - Cohen S
AD  - Ben-Gurion University of the Negev.
LA  - eng
PT  - Journal Article
DEP - 20120705
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Beneficence
MH  - Disclosure/ethics
MH  - Ethical Analysis
MH  - Ethics, Medical
MH  - Humans
MH  - Informed Consent/*ethics/psychology
MH  - *Nocebo Effect
MH  - *Personal Autonomy
MH  - Physician-Patient Relations/*ethics
OTO - NOTNLM
OT  - autonomy
OT  - information disclosure
OT  - informed consent
OT  - nocebo
OT  - respect
OT  - risk-benefit analysis
EDAT- 2012/07/06 06:00
MHDA- 2014/12/15 06:00
CRDT- 2012/07/06 06:00
PHST- 2012/07/06 06:00 [entrez]
PHST- 2012/07/06 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - 10.1111/j.1467-8519.2012.01983.x [doi]
PST - ppublish
SO  - Bioethics. 2014 Mar;28(3):147-54. doi: 10.1111/j.1467-8519.2012.01983.x. Epub
      2012 Jul 5.


PMID- 22762378
OWN - NLM
STAT- MEDLINE
DCOM- 20130404
LR  - 20191210
IS  - 2212-4055 (Electronic)
IS  - 1871-5281 (Linking)
VI  - 11
IP  - 5
DP  - 2012 Oct
TI  - Ghetto poverty and pollution in Egypt: a deadly threat for western countries
      caused by new and infectious mutants. A cultural, social and microbiological
      synopsis.
PG  - 406-19
AB  - Egypt, whose soil germinated the first civilization, monotheism, refined ethics
      and culture of sharing the abundance of extracted natural resources among its
      populace became the crucible proliferating de-novo genotypes of organic and moral
      maladies. The enigma is these mutations are synchronized by several factors,
      namely; failing medical health, if there is any, abundant filth, cultural
      bankruptcy, over population, dogmatic militarism, societal deprivation and
      characterization, etc. These domineering ingredients fossilized Egypt as of 1952 
      coup in an irrevocable national apoptosis, together with the crippled social
      justice and imbalanced distribution of wealth among Egyptians, rates of bacterial
      and viral evolution to second generation resistant to known medical interventions
      are expected to exponentially accelerate. Therefore, it deemed essential to
      elaborate on pollution and psychosis-induced inflammations and grievous crimes
      evoked by dogmatic cults at the breeding source, e.g., ghettos and sporadic
      locations of the homeless in Cairo, Alexandria and Upper Egyptian villages. While
      this second generation of viral and bacterial diseases could labor plagues
      threatening the precariously maintained so-called social fabric of Middle Eastern
      countries, that are uniquely segregating its populace according to their dogmatic
      affiliations and soaked into intolerance, it would definitely compromise the
      integrity of the expensively managed medical care system of developed countries.
FAU - Wassili, J H
AU  - Wassili JH
AD  - Samaritan Biochemists, 279 Khaled ben Waleid, Seidi Gaber, Alexandria, Egypt.
FAU - Baradaeus, Cyril
AU  - Baradaeus C
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Inflamm Allergy Drug Targets
JT  - Inflammation & allergy drug targets
JID - 101266886
RN  - 0 (Bacterial Proteins)
RN  - 0 (Mutant Proteins)
RN  - 0 (Viral Proteins)
SB  - IM
MH  - Animals
MH  - Bacterial Proteins/genetics/immunology
MH  - *Communicable Disease Control
MH  - Egypt/epidemiology
MH  - Environmental Microbiology
MH  - Environmental Pollution/adverse effects
MH  - Humans
MH  - Infections/*epidemiology/transmission
MH  - Mutant Proteins/genetics/immunology
MH  - *Poverty
MH  - Poverty Areas
MH  - Prevalence
MH  - Risk Factors
MH  - Social Justice
MH  - Viral Proteins/genetics/immunology
MH  - Western World
EDAT- 2012/07/06 06:00
MHDA- 2013/04/05 06:00
CRDT- 2012/07/06 06:00
PHST- 2012/06/20 00:00 [received]
PHST- 2012/06/27 00:00 [revised]
PHST- 2012/06/30 00:00 [accepted]
PHST- 2012/07/06 06:00 [entrez]
PHST- 2012/07/06 06:00 [pubmed]
PHST- 2013/04/05 06:00 [medline]
AID - CDTIA-EPUB-20120702-2 [pii]
AID - 10.2174/187152812803250962 [doi]
PST - ppublish
SO  - Inflamm Allergy Drug Targets. 2012 Oct;11(5):406-19. doi:
      10.2174/187152812803250962.


PMID- 22762369
OWN - NLM
STAT- MEDLINE
DCOM- 20141124
LR  - 20140304
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 28
IP  - 3
DP  - 2014 Mar
TI  - Living organ procurement from the mentally incompetent: the need for more
      appropriate guidelines.
PG  - 101-9
LID - 10.1111/j.1467-8519.2012.01982.x [doi]
AB  - With the case of Belgium as a negative example, this paper will evaluate the
      legitimacy of using mentally incompetents as organ sources. The first section
      examines the underlying moral dilemma that results from the necessity of
      balancing the principle of respect for persons with the obligation to help people
      in desperate need. We argue for the rejection of a radical utilitarian approach
      but also question the appropriateness of a categorical prohibition. Section two
      aims to strike a fair balance between the competing interests at stake and to
      define the conditions under which organ harvest from mentally incompetents might 
      be morally acceptable. To this end, we morally assess the main requirements that 
      have been put forward to allow organ removal from incompetent donors. We conclude
      that the current Belgian legislation is far too permissive and that national
      regulations that do not permit the harvest of non-regenerable organs from
      mentally incompetents in exceptional circumstances are too restrictive. On the
      basis of this discussion, we propose a number of guiding principles for
      decision-making in this area.
CI  - (c) 2012 John Wiley & Sons Ltd.
FAU - Van Assche, Kristof
AU  - Van Assche K
AD  - Faculty of Law and Criminology of the Vrije Universiteit Brussel (VUB) University
      of Liege (ULg), Belgium Ghent University, Belgium and Vrije Universiteit Brussel 
      (VUB).
FAU - Genicot, Gilles
AU  - Genicot G
FAU - Sterckx, Sigrid
AU  - Sterckx S
LA  - eng
PT  - Journal Article
DEP - 20120705
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Belgium
MH  - Cognition
MH  - Cost-Benefit Analysis
MH  - Decision Making/*ethics
MH  - Emotions
MH  - Humans
MH  - Informed Consent
MH  - Interdisciplinary Communication
MH  - Interpersonal Relations
MH  - Kidney Transplantation/*ethics/psychology
MH  - Legal Guardians
MH  - *Living Donors
MH  - *Mental Competency
MH  - Morals
MH  - Practice Guidelines as Topic/*standards
MH  - Risk
MH  - Tissue and Organ Harvesting/*ethics/psychology
OTO - NOTNLM
OT  - ethical criteria
OT  - living donation
OT  - mentally incompetents
OT  - organ transplantation
EDAT- 2012/07/06 06:00
MHDA- 2014/12/15 06:00
CRDT- 2012/07/06 06:00
PHST- 2012/07/06 06:00 [entrez]
PHST- 2012/07/06 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - 10.1111/j.1467-8519.2012.01982.x [doi]
PST - ppublish
SO  - Bioethics. 2014 Mar;28(3):101-9. doi: 10.1111/j.1467-8519.2012.01982.x. Epub 2012
      Jul 5.


PMID- 22762352
OWN - NLM
STAT- MEDLINE
DCOM- 20141124
LR  - 20211021
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 28
IP  - 3
DP  - 2014 Mar
TI  - A costly separation between withdrawing and withholding treatment in intensive
      care.
PG  - 127-37
LID - 10.1111/j.1467-8519.2012.01981.x [doi]
AB  - Ethical analyses, professional guidelines and legal decisions support the
      equivalence thesis for life-sustaining treatment: if it is ethical to withhold
      treatment, it would be ethical to withdraw the same treatment. In this paper we
      explore reasons why the majority of medical professionals disagree with the
      conclusions of ethical analysis. Resource allocation is considered by clinicians 
      to be a legitimate reason to withhold but not to withdraw intensive care
      treatment. We analyse five arguments in favour of non-equivalence, and find only 
      relatively weak reasons to restrict rationing to withholding treatment. On the
      contrary, resource allocation provides a strong argument in favour of
      equivalence: non-equivalence causes preventable death in critically ill patients.
      We outline two proposals for increasing equivalence in practice: (1) reduction of
      the mortality threshold for treatment withdrawal, (2) time-limited trials of
      intensive care. These strategies would help to move practice towards more
      rational treatment limitation decisions.
CI  - (c) 2012 John Wiley & Sons Ltd.
FAU - Wilkinson, Dominic
AU  - Wilkinson D
AD  - Women's and Children's Hospital, Adelaide University of Oxford, St Cross College,
      Oxford, and Oxford Uehiro Centre for Practical Ethics and Oxford Centre for
      Neuroethics.
FAU - Savulescu, Julian
AU  - Savulescu J
LA  - eng
GR  - 086041/Wellcome Trust/United Kingdom
GR  - 086041/Z/08/Z/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120705
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - *Conflict of Interest
MH  - Critical Care/*ethics
MH  - Ethical Analysis
MH  - Ethics, Medical
MH  - Euthanasia, Passive/ethics
MH  - Health Care Rationing/*ethics
MH  - Hospital Mortality
MH  - Humans
MH  - *Informed Consent
MH  - Morals
MH  - Patient Admission
MH  - Time Factors
MH  - United Kingdom
MH  - Vulnerable Populations
MH  - *Wedge Argument
MH  - Withholding Treatment/*ethics
PMC - PMC3465577
MID - UKMS48524
OID - NLM: UKMS48524
OTO - NOTNLM
OT  - health care rationing
OT  - intensive care
OT  - medical ethics
OT  - resource allocation
OT  - withholding treatment
EDAT- 2012/07/06 06:00
MHDA- 2014/12/15 06:00
CRDT- 2012/07/06 06:00
PHST- 2012/07/06 06:00 [entrez]
PHST- 2012/07/06 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - 10.1111/j.1467-8519.2012.01981.x [doi]
PST - ppublish
SO  - Bioethics. 2014 Mar;28(3):127-37. doi: 10.1111/j.1467-8519.2012.01981.x. Epub
      2012 Jul 5.


PMID- 22762192
OWN - NLM
STAT- MEDLINE
DCOM- 20120821
LR  - 20190518
IS  - 0261-1929 (Print)
IS  - 0261-1929 (Linking)
VI  - 40
IP  - 2
DP  - 2012 May
TI  - The perception of students on the use of animals in higher education at the
      Federal University of Parana, Southern Brazil.
PG  - 83-90
AB  - The use of animals in education and research is a controversial issue that
      involves ethical considerations. In Brazil, Act 11,794, which was approved in
      2008, established the National Council on the Control of Animal Experimentation
      (CONCEA) and a database of institutions that use animals for research and
      education (CIUCA). This legislation also set out the regulations for the use of
      animals. In this study, we have evaluated the ethical issues involved in the use 
      of animals for educational purposes at the Federal University of Parana, through 
      a qualitative-quantitative analysis that relied on written questionnaires. Our
      objective was to find out the opinions of students and staff from different
      academic fields, and at different stages in their professional development, on
      the use of animals for educational purposes. The study involved 101 students and 
      20 lecturers (i.e. tenure-track professors and all those who teach the students) 
      in Biology, Pharmacology, Medicine and Veterinary Medicine. Approximately half of
      the students (45.5%) did not know the legislation that regulates the use of
      animals in education, and most of the lecturers believed that learning goals
      could not be achieved with alternative methods. Only 38.9% of the lecturers and
      31.9% of the students trusted the usefulness of alternative methods. Furthermore,
      recent graduates were as unaware of the legislation, as were students in the
      first two years of their university courses. These results suggest that it is
      necessary to considerably expand the discussion on alternatives to animal use in 
      the academic environment.
CI  - 2012 FRAME.
FAU - Deguchi, Bernardo G F
AU  - Deguchi BG
AD  - Animal Welfare Laboratory, Federal University of Parana, Curitiba, Brazil.
      nani_bd@ig.com.br
FAU - Molento, Carla F M
AU  - Molento CF
FAU - de Souza, Carlos E P
AU  - de Souza CE
LA  - eng
PT  - Journal Article
PL  - England
TA  - Altern Lab Anim
JT  - Alternatives to laboratory animals : ATLA
JID - 8110074
SB  - IM
MH  - Animal Experimentation/ethics/*legislation & jurisprudence
MH  - Animal Use Alternatives
MH  - Animals
MH  - Brazil
MH  - Humans
MH  - Learning
MH  - Perception
MH  - Students
MH  - Teaching
MH  - Universities
EDAT- 2012/07/06 06:00
MHDA- 2012/08/22 06:00
CRDT- 2012/07/06 06:00
PHST- 2012/07/06 06:00 [entrez]
PHST- 2012/07/06 06:00 [pubmed]
PHST- 2012/08/22 06:00 [medline]
AID - 10.1177/026119291204000207 [doi]
PST - ppublish
SO  - Altern Lab Anim. 2012 May;40(2):83-90. doi: 10.1177/026119291204000207.


PMID- 22761292
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 4
DP  - 2012
TI  - Understanding integrated care pathways in palliative care using realist
      evaluation: a mixed methods study protocol.
LID - 10.1136/bmjopen-2012-001533 [doi]
LID - e001533 [pii]
AB  - INTRODUCTION: Policy- and evidence-based guidelines have highlighted the need for
      improved palliative and end-of-life care. However, there is still evidence of
      individuals dying undignified deaths with little pain control, therefore
      inflicting unnecessary suffering. New commissioning powers have enabled a 2-year 
      pilot of an innovative integrated care pathway (ICP) designed to improve
      arrangements for individuals with life-limiting illnesses requiring palliative
      care. A novel feature of the ICP is its focus on palliative care over the last 6 
      months of life, aiming to intervene early to prepare for and ensure a good death.
      What is not known is if this pathway works, how it works and who it works for.
      METHODS AND ANALYSIS: A realist evaluation and a complex analytical framework
      will investigate and discover context, mechanism and outcome conjectures and
      configurations of the ICP and thus facilitate exploration of how it works and who
      it works for. A mixed methods approach will be used with small sample sizes to
      capture the breadth of the ICP. Phase 1 will identify if the pathway works
      through analysis of NHS Morbidity Information Query and Export Syntax data,
      locality Death Audit data and the Quality of Dying and Death Questionnaire. Phase
      2 employs soft systems methodology with data from focus groups with health
      professionals to identify how the pathway works. Phase 3 uses the Miller
      Behavioural Style Scale and interviews with palliative care patients and bereaved
      relatives to analyse communication in palliative care. ETHICS AND DISSEMINATION: 
      Ethical approval has been granted from the NHS local ethics committee (REC
      reference number: 11/NE/0318). Research & Development approval has been gained
      from four different trusts, and relevant voluntary organisations and the local
      council have been informed about the research. This protocol illustrates the
      complexity inherent in evaluating a palliative care ICP. Identification of
      whether the pathway works, how it works and who it works for will be beneficial
      to all practices and other care providers involved as it will give objective data
      on the impact of the ICP. Results will be disseminated throughout the study for
      continuous quality improvement of the ICP. Outcomes from each data collection
      phase will be disseminated separately if analysis warrants it; all data
      collection will be utilised in the realist evaluation. The research provides a
      potential for the dissemination of the pathway to other localities through the
      transferable knowledge it will generate, from its focus on the contexts that are 
      crucial for successful implementation, the mechanisms that facilitate
      implementation and the outcomes achieved.
FAU - Dalkin, Sonia Michelle
AU  - Dalkin SM
AD  - School of Health, Community and Education Studies, Northumbria University,
      Newcastle upon Tyne, UK.
FAU - Jones, Diana
AU  - Jones D
FAU - Lhussier, Monique
AU  - Lhussier M
FAU - Cunningham, Bill
AU  - Cunningham B
LA  - eng
PT  - Journal Article
DEP - 20120702
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3391371
EDAT- 2012/07/05 06:00
MHDA- 2012/07/05 06:01
CRDT- 2012/07/05 06:00
PHST- 2012/07/05 06:00 [entrez]
PHST- 2012/07/05 06:00 [pubmed]
PHST- 2012/07/05 06:01 [medline]
AID - bmjopen-2012-001533 [pii]
AID - 10.1136/bmjopen-2012-001533 [doi]
PST - epublish
SO  - BMJ Open. 2012 Jul 2;2(4). pii: bmjopen-2012-001533. doi:
      10.1136/bmjopen-2012-001533. Print 2012.


PMID- 22761291
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 4
DP  - 2012
TI  - A randomised controlled trial evaluating a rehabilitation complex intervention
      for patients following intensive care discharge: the RECOVER study.
LID - 10.1136/bmjopen-2012-001475 [doi]
LID - e001475 [pii]
AB  - INTRODUCTION: Patients who survive an intensive care unit admission frequently
      suffer physical and psychological morbidity for many months after discharge.
      Current rehabilitation pathways are often fragmented and little is known about
      the optimum method of promoting recovery. Many patients suffer reduced quality of
      life. METHODS AND ANALYSIS: The authors plan a multicentre randomised parallel
      group complex intervention trial with concealment of group allocation from
      outcome assessors. Patients who required more than 48 h of mechanical ventilation
      and are deemed fit for intensive care unit discharge will be eligible. Patients
      with primary neurological diagnoses will be excluded. Participants will be
      randomised into one of the two groups: the intervention group will receive
      standard ward-based care delivered by the NHS service with additional treatment
      by a specifically trained generic rehabilitation assistant during ward stay and
      via telephone contact after hospital discharge and the control group will receive
      standard ward-based care delivered by the current NHS service. The intervention
      group will also receive additional information about their critical illness and
      access to a critical care physician. The total duration of the intervention will 
      be from randomisation to 3 months postrandomisation. The total duration of
      follow-up will be 12 months from randomisation for both groups. The primary
      outcome will be the Rivermead Mobility Index at 3 months. Secondary outcomes will
      include measures of physical and psychological morbidity and function, quality of
      life and survival over a 12-month period. A health economic evaluation will also 
      be undertaken. Groups will be compared in relation to primary and secondary
      outcomes; quantitative analyses will be supplemented by focus groups with
      patients, carers and healthcare workers. ETHICS AND DISSEMINATION: Consent will
      be obtained from patients and relatives according to patient capacity. Data will 
      be analysed according to a predefined analysis plan. TRIAL REGISTRATION: The
      trial is registered as ISRCTN09412438 and funded by the Chief Scientist Office,
      Scotland.
FAU - Walsh, Timothy Simon
AU  - Walsh TS
AD  - Centre for Inflammation Research, Queens Medical Research Institute, Edinburgh,
      UK.
FAU - Salisbury, Lisa G
AU  - Salisbury LG
FAU - Boyd, Julia
AU  - Boyd J
FAU - Ramsay, Pamela
AU  - Ramsay P
FAU - Merriweather, Judith
AU  - Merriweather J
FAU - Huby, Guro
AU  - Huby G
FAU - Forbes, John
AU  - Forbes J
FAU - Rattray, Janice Z
AU  - Rattray JZ
FAU - Griffith, David M
AU  - Griffith DM
FAU - Mackenzie, Simon J
AU  - Mackenzie SJ
FAU - Hull, Alastair
AU  - Hull A
FAU - Lewis, Steff
AU  - Lewis S
FAU - Murray, Gordon D
AU  - Murray GD
LA  - eng
GR  - CZH/4/531/CSO_/Chief Scientist Office/United Kingdom
GR  - ETM/221/CSO_/Chief Scientist Office/United Kingdom
GR  - G0901697/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
DEP - 20120702
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3391367
EDAT- 2012/07/05 06:00
MHDA- 2012/07/05 06:01
CRDT- 2012/07/05 06:00
PHST- 2012/07/05 06:00 [entrez]
PHST- 2012/07/05 06:00 [pubmed]
PHST- 2012/07/05 06:01 [medline]
AID - bmjopen-2012-001475 [pii]
AID - 10.1136/bmjopen-2012-001475 [doi]
PST - epublish
SO  - BMJ Open. 2012 Jul 2;2(4). pii: bmjopen-2012-001475. doi:
      10.1136/bmjopen-2012-001475. Print 2012.


PMID- 22761290
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 4
DP  - 2012
TI  - Touch screen computer health assessment in Australian general practice patients: 
      a cross-sectional study protocol.
LID - 10.1136/bmjopen-2012-001405 [doi]
LID - e001405 [pii]
AB  - INTRODUCTION: Cardiovascular disease (CVD) and cancer are leading causes of death
      globally. Early detection of cancer and risk factors for CVD may improve health
      outcomes and reduce mortality. General practitioners (GPs) are accessed by the
      majority of the population and play a key role in the prevention and early
      detection of chronic disease risk factors. This cross-sectional study aims to
      assess the acceptability of an electronic method of data collection in general
      practice patients. The study will describe the proportion screened in line with
      guidelines for CVD risk factors and cancer as well as report the prevalence of
      depression, lifestyle risk factors, level of provision of preconception care,
      cervical cancer vaccination and bone density testing. Lastly, the study will
      assess the level of agreement between GPs and patients perception regarding
      presence of risk factors and screening. METHODS AND ANALYSIS: The study has been 
      designed to maximise recruitment of GPs by including practitioners in the
      research team, minimising participation burden on GPs and offering remuneration
      for participation. Patient recruitment will be carried out by a research
      assistant located in general practice waiting rooms. Participants will be asked
      regarding the acceptability of the touch screen computer and to report on a range
      of health risk and preventive behaviours using the touch screen computer. GPs
      will complete a one-page survey indicating their perception of the presence of
      risk behaviours in their patients. Descriptive statistics will be generated to
      describe the acceptability of the touch screen and prevalence of health risk
      behaviours. Cohen's kappa will be used to assess agreement between GP and patient
      perception of presence of health risk behaviours. ETHICS AND DISSEMINATION: This 
      study has been approved by the human research committees in participating
      universities. Findings will be disseminated via peer-reviewed publications,
      conference presentations as well as practice summaries provided to participating 
      practices.
FAU - Yoong, Sze Lin
AU  - Yoong SL
AD  - The Priority Research Centre for Health Behaviour, School of Medicine and Public,
      Health Faculty of Health, The University of Newcastle, Callaghan, New South
      Wales, Australia.
FAU - Carey, Mariko Leanne
AU  - Carey ML
FAU - Sanson-Fisher, Robert William
AU  - Sanson-Fisher RW
FAU - Russell, Grant
AU  - Russell G
FAU - Mazza, Danielle
AU  - Mazza D
FAU - Makeham, Meredith
AU  - Makeham M
FAU - Paul, Christine Louise
AU  - Paul CL
FAU - Inder, Kerry Jane
AU  - Inder KJ
FAU - D'Este, Catherine
AU  - D'Este C
LA  - eng
PT  - Journal Article
DEP - 20120702
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3448137
EDAT- 2012/07/05 06:00
MHDA- 2012/07/05 06:01
CRDT- 2012/07/05 06:00
PHST- 2012/07/05 06:00 [entrez]
PHST- 2012/07/05 06:00 [pubmed]
PHST- 2012/07/05 06:01 [medline]
AID - bmjopen-2012-001405 [pii]
AID - 10.1136/bmjopen-2012-001405 [doi]
PST - epublish
SO  - BMJ Open. 2012 Jul 2;2(4). pii: bmjopen-2012-001405. doi:
      10.1136/bmjopen-2012-001405. Print 2012.


PMID- 22760427
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20151119
IS  - 1529-7535 (Print)
IS  - 1529-7535 (Linking)
VI  - 13
IP  - 5
DP  - 2012 Sep
TI  - Futility: unilateral decision making is not the default for pediatric
      intensivists.
PG  - e311-5
LID - 10.1097/PCC.0b013e31824ea12c [doi]
AB  - OBJECTIVE: Many hospitals have established medical futility policies allowing a
      physician to withdraw or withhold treatment considered futile against families'
      wishes, although little is known on how these policies are used. The goal of our 
      study was to elucidate the perspective of pediatric critical care physicians on
      futility. METHODS: We sent an anonymous survey to all active members of the
      American Academy of Pediatrics Section of Critical Care, using Survey Monkey
      http://www.surveymonkey.com as the questionnaire tool. The survey included four
      clinical vignettes where families desired care that could be perceived as futile 
      care. In each scenario, participants were asked if they would go against the
      families' wishes and how they would resolve the conflict. RESULTS: There were 266
      of 618 (43%) respondents. For an infant with severe hypoxic ischemic injury and
      intestinal failure, the majority of physicians (83.7%) would not enact a
      unilateral do not attempt resuscitation order. For an oncology patient with
      multiorgan system failure and encephalopathy, the majority (90.4%) would not
      enact a unilateral donotattemptresuscitation. In the case where a child was
      declared brain dead, 54.3% of physicians would support unilateral
      donotattemptresuscitation, yet a third (33.1%) would continue mechanical
      ventilation. In the case of cardiac surgery for a patient with trisomy 13, the
      majority (67.1%) would not advocate for surgery. In most scenarios, intensivists 
      cited consultation from the ethics committee (53.8%-76.6%) as the most
      appropriate way to resolve the conflict. Qualitative data revealed intensivists
      would prefer to honor families' wishes and utilize time with support from a
      multidisciplinary team rather than unilateral do not attempt resuscitation to
      resolve these conflicts. CONCLUSIONS: The majority of pediatric intensivists are 
      not in support of unilateral do-not-attempt resuscitation or withholding care
      against families' wishes for a variety of reasons. Given this understandable
      reluctance on the part of the physicians for enforcing decisions, providing
      unqualified support to families at this difficult time is imperative. Further
      research is needed to facilitate decision making that respects the moral
      integrity of families and physicians.
FAU - Morparia, Kavita
AU  - Morparia K
AD  - Albert Einstein Medical Center, Philadelphia, PA, USA.
FAU - Dickerman, Mindy
AU  - Dickerman M
FAU - Hoehn, K Sarah
AU  - Hoehn KS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pediatr Crit Care Med
JT  - Pediatric critical care medicine : a journal of the Society of Critical Care
      Medicine and the World Federation of Pediatric Intensive and Critical Care
      Societies
JID - 100954653
SB  - IM
CIN - Pediatr Crit Care Med. 2012 Sep;13(5):612-3. PMID: 22955469
MH  - *Attitude of Health Personnel
MH  - *Decision Making/ethics
MH  - Humans
MH  - Intensive Care Units, Pediatric
MH  - Medical Futility/ethics/*psychology
MH  - Medical Staff, Hospital/*psychology
MH  - Professional-Family Relations
MH  - *Resuscitation Orders/ethics
MH  - Surveys and Questionnaires
MH  - *Withholding Treatment/ethics
EDAT- 2012/07/05 06:00
MHDA- 2013/03/13 06:00
CRDT- 2012/07/05 06:00
PHST- 2012/07/05 06:00 [entrez]
PHST- 2012/07/05 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
AID - 10.1097/PCC.0b013e31824ea12c [doi]
PST - ppublish
SO  - Pediatr Crit Care Med. 2012 Sep;13(5):e311-5. doi: 10.1097/PCC.0b013e31824ea12c.


PMID- 22759805
OWN - NLM
STAT- MEDLINE
DCOM- 20130131
LR  - 20211021
IS  - 1756-0500 (Electronic)
IS  - 1756-0500 (Linking)
VI  - 5
DP  - 2012 Jul 3
TI  - From anonymity to "open doors": IRB responses to tensions with researchers.
PG  - 347
LID - 10.1186/1756-0500-5-347 [doi]
AB  - BACKGROUND: Tensions between IRBs and researchers in the US and elsewhere have
      increased, and may affect whether, how, and to what degree researchers comply
      with ethical guidelines. Yet whether, how, when, and why IRBs respond to these
      conflicts have received little systematic attention. FINDINGS: I contacted 60 US 
      IRBs (every fourth one in the list of the top 240 institutions by NIH funding),
      and interviewed leaders from 34 (response rate = 55%) and an additional 12
      members and administrators. IRBs often try to respond to tensions with
      researchers and improve relationships in several ways, but range widely in how,
      when, and to what degree (e.g., in formal and informal structure, content, and
      tone of interactions). IRBs varied from open and accessible to more distant and
      anonymous, and in the amount and type of "PR work" and outreach they do. Many
      boards seek to improve the quantity, quality, and helpfulness of communication
      with PIs, but differ in how. IRBs range in meetings from open to closed, and may 
      have clinics and newsletters. Memos can vary in helpfulness and tone (e.g., using
      "charm"). IRBs range considerably, too, in the degrees to which they seek to
      educate PIs, showing them the underlying ethical principles. But these efforts
      take time and resources, and IRBs thus vary in degrees of responses to PI
      complaints. CONCLUSIONS: This study, the first to explore the mechanisms through 
      which IRBs respond to tensions and interactions with PIs, suggests that these
      committees seek to respond to conflicts with PIs in varying ways - both formal
      and informal, involving both the form and content of communications. This study
      has important implications for future practice, research, and policy, suggesting 
      needs for increased attention to not only what IRBs communicate to PIs, but how
      (i.e., the tone and the nature of interactions). IRBs can potentially improve
      relationships with PIs in several ways: using more "open doors" rather than
      anonymity, engaging in outreach (e.g., through clinics), enhancing the tone as
      well as content of interactions, educating PIs about the underlying ethics, and
      helping PIs as much and proactively as possible. Increased awareness of these
      issues can help IRBs and researchers in the US and elsewhere.
FAU - Klitzman, Robert
AU  - Klitzman R
AD  - Department of Psychiatry, Columbia University, New York, NY, USA.
      rlk2@columbia.edu
LA  - eng
GR  - 5-G13-LM009996-02/LM/NLM NIH HHS/United States
GR  - R01-NG04214/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20120703
PL  - England
TA  - BMC Res Notes
JT  - BMC research notes
JID - 101462768
SB  - IM
MH  - Attitude
MH  - *Biomedical Research/ethics/standards
MH  - *Conflict, Psychological
MH  - *Ethics Committees, Research/ethics
MH  - Female
MH  - Guideline Adherence
MH  - Guidelines as Topic
MH  - Humans
MH  - *Interdisciplinary Communication
MH  - Interviews as Topic
MH  - Male
MH  - Perception
MH  - Professional Role
MH  - Research Personnel/ethics/*psychology
MH  - United States
MH  - Workforce
PMC - PMC3461423
EDAT- 2012/07/05 06:00
MHDA- 2013/02/01 06:00
CRDT- 2012/07/05 06:00
PHST- 2011/10/13 00:00 [received]
PHST- 2012/06/14 00:00 [accepted]
PHST- 2012/07/05 06:00 [entrez]
PHST- 2012/07/05 06:00 [pubmed]
PHST- 2013/02/01 06:00 [medline]
AID - 1756-0500-5-347 [pii]
AID - 10.1186/1756-0500-5-347 [doi]
PST - epublish
SO  - BMC Res Notes. 2012 Jul 3;5:347. doi: 10.1186/1756-0500-5-347.


PMID- 22759450
OWN - NLM
STAT- MEDLINE
DCOM- 20130403
LR  - 20120822
IS  - 1421-9786 (Electronic)
IS  - 1015-9770 (Linking)
VI  - 34
IP  - 1
DP  - 2012
TI  - Perfusion computed tomography-guided intravenous thrombolysis for acute ischemic 
      stroke beyond 4.5 hours: a case-control study.
PG  - 31-7
LID - 10.1159/000338778 [doi]
AB  - BACKGROUND: Extending the therapeutic window of intravenous thrombolysis for
      acute ischemic stroke beyond the established 4.5-hour limit is of critical
      importance in order to increase the proportion of thrombolysed stroke patients.
      In this setting, the capacity of MRI to select acute stroke patients for
      reperfusion therapies in delayed time windows has been and is being tested in
      clinical trials. However, whether the more available and cost-effective perfusion
      computed tomography (PCT) may be useful to select candidates for delayed
      intravenous thrombolysis remains largely unexplored. We aimed to evaluate the
      safety and efficacy of PCT-guided intravenous thrombolysis beyond 4.5 h after
      stroke onset. METHODS: We prospectively studied all consecutive acute ischemic
      stroke patients treated with intravenous tissue plasminogen activator (tPA) in
      our stroke unit between January 2008 and December 2010. Patients treated within
      0- 4.5 h were treated according to non-contrast CT (NCCT) criteria. Beyond 4.5 h,
      patients received intravenous tPA according to PCT criteria, i.e. an infarct core
      on cerebral blood volume (CBV) maps not exceeding one third of the middle
      cerebral artery (MCA) territory and tissue at risk as defined by mean transit
      time-CBV mismatch greater than 20%. Predetermined primary endpoints were
      symptomatic hemorrhagic transformation and favorable long-term outcome, while
      early neurological improvement and MCA recanalization were considered secondary
      endpoints. Statistical analysis included bivariate comparisons between the two
      groups for each endpoint and logistic regression models when significance was
      found in bivariate analyses. This study was approved by our local ethics
      committee. RESULTS: A total of 245 patients received intravenous thrombolysis.
      After the groups were matched by baseline National Institutes of Health Stroke
      Scale score, 172 patients treated at <4.5 h and 43 patients treated at >4.5 h
      were finally included. Early and late groups were comparable regarding baseline
      variables; only cardioembolic etiology was more frequent in the >4.5 h group.
      Rates of symptomatic hemorrhagic transformation (2.9% in the <4.5 h group vs.
      2.3% in the >4.5 h group; p = 1.0) and good long-term outcome (64.5 vs. 60.5%,
      respectively; p = 0.620) were similar between the groups. However, delayed
      intravenous thrombolysis was independently associated with a worse early clinical
      course [odds ratio (OR) 2.07, 95% confidence interval (CI) 1.04-4.1; p = 0.038]
      and lower 2-hour MCA recanalization rates (OR 0.4, 95% CI 0.17-0.92; p = 0.03).
      CONCLUSION: Primary safety and efficacy endpoints were comparable between the
      early and delayed thrombolysis groups. The results of our exploratory study may
      justify a randomized clinical trial to test the safety and efficacy of PCT-guided
      intravenous thrombolysis in acute ischemic stroke patients presenting beyond 4.5 
      h from symptom onset.
CI  - Copyright (c) 2012 S. Karger AG, Basel.
FAU - Garcia-Bermejo, Pablo
AU  - Garcia-Bermejo P
AD  - Stroke Unit, Department of Neurology, Hospital Clinico Universitario, Valladolid,
      Spain. pablerah@hotmail.com
FAU - Calleja, Ana I
AU  - Calleja AI
FAU - Perez-Fernandez, Santiago
AU  - Perez-Fernandez S
FAU - Cortijo, Elisa
AU  - Cortijo E
FAU - del Monte, Jose M
AU  - del Monte JM
FAU - Garcia-Porrero, Miguel
AU  - Garcia-Porrero M
FAU - Fe Munoz, M
AU  - Fe Munoz M
FAU - Fernandez-Herranz, Rosario
AU  - Fernandez-Herranz R
FAU - Arenillas, Juan F
AU  - Arenillas JF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120629
PL  - Switzerland
TA  - Cerebrovasc Dis
JT  - Cerebrovascular diseases (Basel, Switzerland)
JID - 9100851
RN  - EC 3.4.21.68 (Tissue Plasminogen Activator)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain Ischemia/*drug therapy
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Injections, Intravenous/methods
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Middle Aged
MH  - Perfusion/methods
MH  - Stroke/*drug therapy
MH  - Thrombolytic Therapy/*methods
MH  - Time Factors
MH  - Tissue Plasminogen Activator/administration & dosage/*therapeutic use
MH  - Tomography, X-Ray Computed/*methods
MH  - Treatment Outcome
EDAT- 2012/07/05 06:00
MHDA- 2013/04/04 06:00
CRDT- 2012/07/05 06:00
PHST- 2012/03/02 00:00 [received]
PHST- 2012/04/02 00:00 [accepted]
PHST- 2012/07/05 06:00 [entrez]
PHST- 2012/07/05 06:00 [pubmed]
PHST- 2013/04/04 06:00 [medline]
AID - 000338778 [pii]
AID - 10.1159/000338778 [doi]
PST - ppublish
SO  - Cerebrovasc Dis. 2012;34(1):31-7. doi: 10.1159/000338778. Epub 2012 Jun 29.


PMID- 22758369
OWN - NLM
STAT- MEDLINE
DCOM- 20130131
LR  - 20181201
IS  - 1557-8577 (Electronic)
IS  - 1549-1684 (Linking)
VI  - 15
IP  - 3
DP  - 2012 Jun
TI  - Interview with Zhaxybay Zhumadilov, M.D., Ph.D. Interview by Vicki Glaser.
PG  - 339-42
LID - 10.1089/rej.2012.1353 [doi]
AB  - EDITOR'S NOTE: The interview series in Rejuvenation Research is a unique and, I
      believe, highly valuable feature of the Journal, giving readers insights into the
      thinking and motivation of some of the most influential movers and shakers in the
      many disciplines-not only scientific but also political, sociological, ethical,
      and more-that impinge on the crusade to defeat aging. Dissemination of the views 
      and insights of such people is essential to the process of communication between 
      the field of biomedical gerontology and the many constituencies that will be
      affected by progress against aging, a dialogue that, as I and others have noted
      recently, is essential if we are to develop effective interventions against aging
      with all possible speed.
FAU - Zhumadilov, Zhaxybay
AU  - Zhumadilov Z
LA  - eng
PT  - Autobiography
PT  - Biography
PT  - Historical Article
PT  - Interview
PT  - Portrait
PL  - United States
TA  - Rejuvenation Res
JT  - Rejuvenation research
JID - 101213381
SB  - IM
MH  - Aging/physiology
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Kazakhstan
MH  - Regenerative Medicine/*history
PS  - Zhaxybay Z
FPS - Zhaxybay, Zhaxybay
EDAT- 2012/07/05 06:00
MHDA- 2013/02/01 06:00
CRDT- 2012/07/05 06:00
PHST- 2012/07/05 06:00 [entrez]
PHST- 2012/07/05 06:00 [pubmed]
PHST- 2013/02/01 06:00 [medline]
AID - 10.1089/rej.2012.1353 [doi]
PST - ppublish
SO  - Rejuvenation Res. 2012 Jun;15(3):339-42. doi: 10.1089/rej.2012.1353.


PMID- 22755501
OWN - NLM
STAT- MEDLINE
DCOM- 20120731
LR  - 20120704
IS  - 1120-9135 (Print)
IS  - 1120-9135 (Linking)
VI  - 24
IP  - 2
DP  - 2012 Mar-Apr
TI  - [Comment to DPR 177/011].
PG  - 145-53
AB  - The subject of this study is the analysis of DPR 177/2011 regarding occupational 
      safety in confined environments suspected of pollution The study wishes to
      represent a platform for the knowledge of the relevant principles and issues that
      are the functional basis for occupational health professionals, to offer a scheme
      in which it is possible to implement local actions of occupational prevention in 
      the confined spaces and to help Italian intervention plans Italian within the
      European area, such, e.g., the present "Healthy workplaces campaign working
      together for risk prevention" promoted by the European Agency for Safety and
      Health at Work. The interiorization of this behavioural scheme is needed for
      professionals and authorities in the occupational safety systems, both public and
      private, who have the institutional duty to obtain trheir effectiveness. To
      observe the safety system in the specific matter of confined spaces, their
      essential elements were considered. These elements were identified both in the
      DPR 177/2011 and in other pertinent documents. This study doesn't pretend to
      identify all relevant documents, but wishes to underline the open structure of
      the system for acquiring non strictly juridical documents, such as ICOH
      guidelines and International code of ethics for occupational health professionals
      and pertinent authorities. A specific matter of the study is the different role
      of rules and ethical principles in verifying the adequacy of the safety system.
      The role of guidelines and ethic principles in the internal evaluation of legal
      value was examined for their relevance in order to decide on adequacy of the
      employer's management in safety matter adequacy which can by evaluated looking at
      his effective knowledge of spaces and good selection of managers and
      professionals. Furthermore, the study establishes how central--in reaching the
      safety--is the method based on effectiveness in managing the prevention in
      occupational health. The managerial method, not based on formal interpretation
      but on the effective situation of the spaces and of the human resources, is a
      critical element in safety systems and represents an acceptable scheme for the
      conduct of the subjects in charge for the production cycle. They are those who
      effectively decide on the site, except for some situations, as it is for example 
      the prevision of managerial liability for activity in outsourcing. It has been
      stressed in this study the dynamicity of safety system in confined spaces which
      can be derived by the employer's duty of vigilance for interference risks between
      his activity and the activity of other enterprises operating in outsourcing. This
      duty it is permanent in every space and moment of production cycle. This context 
      of functional responsibility, and liability when it exists, based on reality as
      well as on the knowledge of the spaces and human resources, shows the central
      function of qualified MD and his functionality in both aspects. In the first, he 
      is able to understand various risks existing for health. In the second, for the
      many strict contacts with workers, he can participate in developing their
      information and formation, which have educational importance for the safety
      system of the occupational health. To conclude about the occupational safety
      system, this study stresses that the activity of qualified MD is not a simple
      surveillance carried out by medical examinations as a routine, but it is a
      strategic issue for the realization of organizational wellness at work, which is 
      functional to respect both the human rights and an efficient production cycle.
FAU - De Santis, Anna Elisa
AU  - De Santis AE
AD  - Scuola di Specializzazione in Igiene e Medicina Preventiva, Sapienza Universita
      di Roma. annaelisadesantis@gmail.com
LA  - ita
PT  - English Abstract
PT  - Journal Article
TT  - Commento al DPR 177/2011.
PL  - Italy
TA  - Ann Ig
JT  - Annali di igiene : medicina preventiva e di comunita
JID - 9002865
SB  - IM
MH  - *Guidelines as Topic
MH  - Humans
MH  - Italy
MH  - Occupational Health/*legislation & jurisprudence
MH  - Occupational Medicine/*legislation & jurisprudence
MH  - Work/*legislation & jurisprudence
MH  - Workplace/*legislation & jurisprudence
EDAT- 2012/07/05 06:00
MHDA- 2012/08/01 06:00
CRDT- 2012/07/05 06:00
PHST- 2012/07/05 06:00 [entrez]
PHST- 2012/07/05 06:00 [pubmed]
PHST- 2012/08/01 06:00 [medline]
PST - ppublish
SO  - Ann Ig. 2012 Mar-Apr;24(2):145-53.


PMID- 22755338
OWN - NLM
STAT- MEDLINE
DCOM- 20120814
LR  - 20151119
IS  - 0030-9982 (Print)
IS  - 0030-9982 (Linking)
VI  - 62
IP  - 6
DP  - 2012 Jun
TI  - Size estimation, HIV prevalence and risk behaviours of female sex workers in
      Pakistan.
PG  - 551-7
AB  - OBJECTIVE: To provide size estimation and to determine risky behaviours and HIV
      prevalence among female sex workers in Pakistan, which has progressed from a low 
      to concentrated level of HIV epidemic. METHODS: A cross-sectional study
      (geographic mapping and integrated behavioural and biological survey-IBBS) was
      conducted between August 2005 to January 2006 in Karachi, Hyderabad and Sukkur. A
      detailed questionnaire and dry blood spot (DBS) specimen for HIV testing were
      collected by trained interviewers after informed consent. The study was ethically
      approved by review boards in Canada and Pakistan. RESULTS: About 14,900 female
      sex workers were estimated to be functional in Sindh. A total of 1158 of them
      were interviewed for the study. Average age of sex workers was 27.4 +/- 6.7
      years, and the majority 787 (67.9%) were married, and uneducated 764 (65.9%).
      Sindhi (26.4%) was the predominant ethnicity. Mean number of paid clients was 2.1
      +/- 1.2. three workers were confirmed HIV positive (0.75%, 95 percent CI
      0.2-2.2%) from Karachi. Condom use at last sexual act was highest (68%) among
      brothel-based workers from Karachi, and the lowest in Sukkur where only 1.3%
      street-based workers reported using a condom at last sexual act. Overall use of
      illicit drugs through injections was negligible. CONCLUSION: HIV prevalence among
      female sex workers in Sindh, Pakistan is low but risky behaviours are present.
      Well organised service delivery programmes can help promoting safer practices.
FAU - Altaf, Arshad
AU  - Altaf A
AD  - Canada-Pakistan HIV/AIDS Surveillance Project of Canadian International
      Development Agency, Sindh & National AIDS Control Programme, Karachi & Islamabad.
      arshad.altaf@gmail.com
FAU - Agha, Ajmal
AU  - Agha A
FAU - Holte-McKinzie, Merydth
AU  - Holte-McKinzie M
FAU - Abbas, Qamar
AU  - Abbas Q
FAU - Jafri, Salma Batool
AU  - Jafri SB
FAU - Emmanuel, Faran
AU  - Emmanuel F
LA  - eng
PT  - Journal Article
PL  - Pakistan
TA  - J Pak Med Assoc
JT  - JPMA. The Journal of the Pakistan Medical Association
JID - 7501162
SB  - IM
MH  - Adult
MH  - Cross-Sectional Studies
MH  - Female
MH  - HIV Infections/*epidemiology
MH  - Humans
MH  - Pakistan/epidemiology
MH  - Prevalence
MH  - Risk-Taking
MH  - *Sex Workers
MH  - Surveys and Questionnaires
EDAT- 2012/07/05 06:00
MHDA- 2012/08/15 06:00
CRDT- 2012/07/05 06:00
PHST- 2012/07/05 06:00 [entrez]
PHST- 2012/07/05 06:00 [pubmed]
PHST- 2012/08/15 06:00 [medline]
AID - 3461 [pii]
PST - ppublish
SO  - J Pak Med Assoc. 2012 Jun;62(6):551-7.


PMID- 22755280
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20120704
IS  - 0030-9982 (Print)
IS  - 0030-9982 (Linking)
VI  - 62
IP  - 4
DP  - 2012 Apr
TI  - Outcome of surgical treatment of monocular elevation deficiency.
PG  - 355-7
AB  - OBJECTIVE: To assess the outcome of surgical treatment in patients with monocular
      elevation deficiency. METHODS: This prospective study included 36 patients of
      monocular elevation deficiency surgically treated from January 2006 to June 2009,
      at a tertiary care eye hospital in Rawalpindi, Pakistan. Corrected visual acuity,
      refractive error, ocular examination, orthoptic assessment and ptosis evaluation 
      were recorded. Strabismus surgery was performed according to the results of
      forced duction test (FDT). Ptosis surgery, if required, was performed after the
      strabismus surgery. Patients having any restrictive cause or previous strabismus 
      surgery were excluded. The study conformed to all local laws and was compliant
      with the principles of the Declaration of Helsinki and had the approval of the
      Hospital Ethics Committee. RESULTS: The 36 patients were treated surgically and
      completed the required follow-up. The forced duction test was positive for
      inferior rectus (IR) of the involved eye in 20 of the 36 eyes (55.55%). Twelve
      patients had inferior rectus recession with or without one horizontal muscle
      recession or resection, 12 had Knapp procedure correcting for any horizontal
      deviation if present, 10 had inferior rectus recession followed by Knapp surgery,
      with or without recession or resection of horizontal recti, 1 patient had
      horizontal correction only, while one patient had ptosis correction only without 
      squint surgery. Of the 36 patients, 33 had post-operative (PO) hypotropia within 
      10 prism diopters (PD). Three patients developed consecutive hypertropia.
      CONCLUSION: Careful pre-operative evaluation can lead to satisfactory cosmetic
      improvement after surgery in monocular elevation deficiency. The forced duction
      test should be performed in both eyes so that any associated oblique muscle
      laxity (OML) can be noted.
FAU - Zafar, Saemah Nuzhat
AU  - Zafar SN
AD  - Al-Shifa Trust Eye Hospital, Rawalpindi, Pakistan.
FAU - Azad, Nadia
AU  - Azad N
FAU - Khan, Ayesha
AU  - Khan A
LA  - eng
PT  - Journal Article
PL  - Pakistan
TA  - J Pak Med Assoc
JT  - JPMA. The Journal of the Pakistan Medical Association
JID - 7501162
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Blepharoptosis/complications/*surgery
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Pakistan
MH  - Strabismus/complications/*surgery
MH  - Treatment Outcome
MH  - Visual Acuity
MH  - Young Adult
EDAT- 2012/07/05 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/07/05 06:00
PHST- 2012/07/05 06:00 [entrez]
PHST- 2012/07/05 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
AID - 3358 [pii]
PST - ppublish
SO  - J Pak Med Assoc. 2012 Apr;62(4):355-7.


PMID- 22754443
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 0975-3125 (Electronic)
VI  - 6
IP  - 2
DP  - 2012 Apr
TI  - Cooperation between research institutions and journals on research integrity
      cases: Guidance from the committee on publication ethics.
PG  - 155-60
LID - 10.4103/1658-354X.97030 [doi]
AB  - Institutions and journals both have important duties relating to research and
      publication misconduct. Institutions are responsible for the conduct of their
      researchers and for encouraging a healthy research environment. Journals are
      responsible for the conduct of their editors, for safeguarding the research
      record, and for ensuring the reliability of everything they publish. It is,
      therefore, important for institutions and journals to communicate and collaborate
      effectively on cases relating to research integrity. To achieve this, we make the
      following recommendations.The institutions should:have a research integrity
      officer (or office) and publish their contact details prominentlyinform journals 
      about cases of proven misconduct that affect the reliability or attribution of
      the research that they have publishedrespond to journals if they request
      information about issues, such as, disputed authorship, misleading reporting,
      competing interests, or other factors, including honest errors, that could affect
      the reliability of the published studyinitiate inquiries into allegations of
      research misconduct or unacceptable publication practice raised by journalshave
      policies supporting a responsible research conduct and systems in place for
      investigating suspected research misconduct.The journals should:publish the
      contact details of their editor-in-chief who should act as the point of contact
      for questions relating to research and publication integrityinform institutions
      if they suspect misconduct by their researchers, and provide evidence to support 
      these concernscooperate with investigations and respond to institutions'
      questions about misconduct allegationsbe prepared to issue retractions or
      corrections (according to the COPE guidelines on retractions) when provided with 
      findings of misconduct arising from investigationshave policies for responding to
      institutions and other organizations that investigate cases of research
      misconduct.
FAU - Wager, Elizabeth
AU  - Wager E
AD  - Publications Consultant, Sideview, Princes Risborough, UK.
FAU - Kleinert, Sabine
AU  - Kleinert S
LA  - eng
PT  - Journal Article
PL  - India
TA  - Saudi J Anaesth
JT  - Saudi journal of anaesthesia
JID - 101500601
PMC - PMC3385259
OTO - NOTNLM
OT  - Editors
OT  - ethics
OT  - publications
EDAT- 2012/07/04 06:00
MHDA- 2012/07/04 06:01
CRDT- 2012/07/04 06:00
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2012/07/04 06:01 [medline]
AID - 10.4103/1658-354X.97030 [doi]
AID - SJA-6-155 [pii]
PST - ppublish
SO  - Saudi J Anaesth. 2012 Apr;6(2):155-60. doi: 10.4103/1658-354X.97030.


PMID- 22754436
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 0975-3125 (Electronic)
VI  - 6
IP  - 2
DP  - 2012 Apr
TI  - Ultrasound guidance for central vascular access in the neonatal and pediatric
      intensive care unit.
PG  - 120-4
LID - 10.4103/1658-354X.97023 [doi]
AB  - BACKGROUND: Percutaneous central venous cannulation (CVC) in infants and children
      is a challenging procedure, and it is usually achieved with a blinded, external
      landmark-guided technique. Recent guidelines from the National Institute for
      Clinical Excellence (NICE) recommend the use of ultrasound guidance for central
      venous catheterization in children. The purpose of this study was to evaluate
      this method in a pediatric and neonatal intensive care unit, assessing the number
      of attempts, access time (skin to vein), incidence of complication, and the ease 
      of use for central venous access in the neonatal age group. METHODS: After
      approval by the local departmental ethical committee, we evaluated an
      ultrasound-guided method over a period of 6 months in 20 critically ill patients 
      requiring central venous access in a pediatric intensive care unit and a neonatal
      intensive care unit (median age 9 (0-204) months and weight 9.3 (1.9-60) kg).
      Cannulation was performed after locating the puncture site with the aid of an
      ultrasound device (8 MHz transducer, Vividi General Electrics((R)) Burroughs,
      USA) covered by a sterile sheath. Outcome measures included successful insertion 
      rate, number of attempts, access time, and incidence of complications. RESULTS:
      Cannulation of the central vein was 100% successful in all patients. The right
      femoral vein was preferred in 60% of the cases. The vein was entered on the first
      attempt in 75% of all patients, and the median number of attempts was 1. The
      median access time (skin to vein) for all patients was 64.5 s. No arterial
      punctures or hematomas occurred using the ultrasound technique. CONCLUSIONS: In a
      sample of critically ill patients from a pediatric and neonatal intensive care
      unit, ultrasound-guided CVC compared with published reports on traditional
      technique required fewer attempts and less time. It improved the overall success 
      rate, minimized the occurrence of complications during vein cannulation and was
      easy to apply in neonatal and pediatric patients.
FAU - Al Sofyani, Khouloud
AU  - Al Sofyani K
AD  - Department of Pediatric and Neonatal Intensive Care Unit, Armand Trousseau
      Hospital, APHP, UMPC Paris VI, Paris, France.
FAU - Julia, Guilbert
AU  - Julia G
FAU - Abdulaziz, Boker
AU  - Abdulaziz B
FAU - Yves, Chevalier Jean
AU  - Yves CJ
FAU - Sylvain, Renolleau
AU  - Sylvain R
LA  - eng
PT  - Journal Article
PL  - India
TA  - Saudi J Anaesth
JT  - Saudi journal of anaesthesia
JID - 101500601
EIN - Saudi J Anaesth. 2012 Oct-Dec;6(4):372. Khouloud, Al Sofyani [corrected to Al
      Sofyani, Khouloud]
PMC - PMC3385252
OTO - NOTNLM
OT  - Neonate catheterization
OT  - pediatric
OT  - ultrasound-guided cannulation
OT  - vascular access
EDAT- 2012/07/04 06:00
MHDA- 2012/07/04 06:01
CRDT- 2012/07/04 06:00
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2012/07/04 06:01 [medline]
AID - 10.4103/1658-354X.97023 [doi]
AID - SJA-6-120 [pii]
PST - ppublish
SO  - Saudi J Anaesth. 2012 Apr;6(2):120-4. doi: 10.4103/1658-354X.97023.


PMID- 22754431
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 0975-3125 (Electronic)
VI  - 6
IP  - 2
DP  - 2012 Apr
TI  - Why has the committee on publication ethics developed guidelines for cooperation 
      between journals and research institutions?
PG  - 102-3
LID - 10.4103/1658-354X.97018 [doi]
FAU - Wager, Elizabeth
AU  - Wager E
AD  - Publications Consultant, Sideview, Princes Risborough, UK Chair, Committee on
      Publication Ethics (March 2009 - 2012) E-mail: liz@sideview.demon.co.uk.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Saudi J Anaesth
JT  - Saudi journal of anaesthesia
JID - 101500601
PMC - PMC3385247
EDAT- 2012/07/04 06:00
MHDA- 2012/07/04 06:01
CRDT- 2012/07/04 06:00
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2012/07/04 06:01 [medline]
AID - 10.4103/1658-354X.97018 [doi]
AID - SJA-6-102 [pii]
PST - ppublish
SO  - Saudi J Anaesth. 2012 Apr;6(2):102-3. doi: 10.4103/1658-354X.97018.


PMID- 22754283
OWN - NLM
STAT- MEDLINE
DCOM- 20121120
LR  - 20211021
IS  - 1958-5969 (Electronic)
IS  - 1294-8322 (Linking)
VI  - 14
IP  - 2
DP  - 2012 Jun
TI  - Bereavement, complicated grief, and the rationale for diagnosis in psychiatry.
PG  - 111-3
AB  - Recent controversies over the DSM-5 raise a foundational question for all
      diagnostic classifications: what is their underlying purpose? The author raises
      this question in the context of the proposed elimination of the "bereavement
      exclusion" from the DSM-5; and the possible addition of the category called
      "Complicated Grief." The author argues that our psychiatric diagnostic scheme
      should not be aimed primarily at establishing boundaries among putative "natural 
      types." Rather, it ought to be guided by the principle of "instrumental validity,
      " which focuses on reducing the suffering and incapacity of those who seek our
      care. In so far as the category of "Complicated Grief" helps achieve this goal,
      it will foster the humane and ethical values that underlie medical practice.
FAU - Pies, Ronald
AU  - Pies R
LA  - eng
PT  - Editorial
PL  - England
TA  - Dialogues Clin Neurosci
JT  - Dialogues in clinical neuroscience
JID - 101238198
SB  - IM
MH  - *Adaptation, Psychological
MH  - Adjustment Disorders/*diagnosis/psychology
MH  - *Bereavement
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - *Grief
MH  - Humans
PMC - PMC3384439
EDAT- 2012/07/04 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/04 06:00
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
PST - ppublish
SO  - Dialogues Clin Neurosci. 2012 Jun;14(2):111-3.


PMID- 22754248
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 0974-8245 (Electronic)
IS  - 0974-777X (Linking)
VI  - 4
IP  - 2
DP  - 2012 Apr
TI  - Monitoring data quality in syndromic surveillance: learnings from a resource
      limited setting.
PG  - 120-7
LID - 10.4103/0974-777X.96778 [doi]
AB  - BACKGROUND: India is in the process of integrating all disease surveillance
      systems with the support of a World Bank funded program called the Integrated
      Disease Surveillance System. In this context the objective of the study was to
      evaluate the components of the Orissa Multi Disease Surveillance System.
      MATERIALS AND METHODS: Multistage sampling was carried out, starting with four
      districts, followed by sequentially sampling two blocks; and in each block, two
      sectors and two health sub-centers were selected, all based on the best and worst
      performances. Two study instruments were developed for data validation, for
      assessing the components of the surveillance and diagnostic algorithm. The
      Organizational Ethics Group reviewed and approved the study. RESULTS: In all 178 
      study subjects participated in the survey. The case definition of suspected
      meningitis in disease surveillance was found to be difficult, with only 29.94%,
      who could be correctly identified. Syndromic diagnosis following the diagnostic
      algorithm was difficult for suspected malaria (28.1%), 'unusual syndrome'
      (28.1%), and simple diarrhea (62%). Only 17% could correctly answer questions on 
      follow-up cases, but only 50% prioritized diseases. Our study showed that 54%
      cross-checked the data before compilation. Many (22%) faltered on timeliness even
      during emergencies. The constraints identified were logistics (56%) and
      telecommunication (41%). The reason for participation in surveillance was job
      responsibility (34.83%). CONCLUSIONS: Most of the deficiencies arose from human
      errors when carrying out day-to-day processes of surveillance activities, hence, 
      should be improved by retraining. Enhanced laboratory support and electronic
      transmission would improve data quality and timeliness. Validity of some of the
      case definitions need to be rechecked. Training Programs should focus on
      motivating the surveillance personnel.
FAU - Venkatarao, Epari
AU  - Venkatarao E
AD  - Health Division UNDP, Odisha.
FAU - Patil, Rajan R
AU  - Patil RR
FAU - Prasad, Deepa
AU  - Prasad D
FAU - Anasuya, Anita
AU  - Anasuya A
FAU - Samuel, Reuben
AU  - Samuel R
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Glob Infect Dis
JT  - Journal of global infectious diseases
JID - 101521436
PMC - PMC3385202
OTO - NOTNLM
OT  - Data quality
OT  - Evaluation
OT  - Infectious disease surveillance
EDAT- 2012/07/04 06:00
MHDA- 2012/07/04 06:01
CRDT- 2012/07/04 06:00
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2012/07/04 06:01 [medline]
AID - 10.4103/0974-777X.96778 [doi]
AID - JGID-4-120 [pii]
PST - ppublish
SO  - J Glob Infect Dis. 2012 Apr;4(2):120-7. doi: 10.4103/0974-777X.96778.


PMID- 22754147
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1998-376X (Electronic)
IS  - 0970-0358 (Linking)
VI  - 45
IP  - 1
DP  - 2012 Jan
TI  - Aggressive surgical palliation for advanced girdle tumours.
PG  - 16-21
LID - 10.4103/0970-0358.96571 [doi]
AB  - BACKGROUND: The surgical management of advanced, incurable, malignant disease
      presents particular ethical and technical challenges. The clear goal is
      palliation and the surgical futility must be avoided. This case series presents
      some particular challenges in end-of-life surgery. MATERIALS AND METHODS: Fifteen
      patients referred with advanced malignant disease involving a limb girdle were
      reviewed. RESULTS: In one case, a patient pleaded for surgery after initially
      requesting a delay to seek treatment from a Chinese Traditional Herbalist. The
      increase in tumour bulk led to problems with surgery and the patient died in a
      hospital a few weeks later. This case illustrates 'futility' not recognized and
      encountered. The remaining 14 patients exhibited positive palliation with
      improved quality of dying and appreciation expressed by patients, relatives and
      staff. CONCLUSION: In selected cases, with a skilled and experienced surgical
      team, patients with advanced malignant disease can still benefit from aggressive 
      surgical palliation. The margin of error is small between palliation being
      attempted and futility being achieved. This considerably adds to the challenge of
      end-of-life surgery.
FAU - Burd, Andrew
AU  - Burd A
AD  - Division of Plastic, Reconstructive and Aesthetic Surgery, Department of Surgery,
      The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong.
FAU - Wong, K C
AU  - Wong KC
FAU - Kumta, Shekhar M
AU  - Kumta SM
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Indian J Plast Surg
JT  - Indian journal of plastic surgery : official publication of the Association of
      Plastic Surgeons of India
JID - 8405356
PMC - PMC3385388
OTO - NOTNLM
OT  - Futility
OT  - palliation
OT  - quality of life
OT  - surgery
EDAT- 2012/07/04 06:00
MHDA- 2012/07/04 06:01
CRDT- 2012/07/04 06:00
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2012/07/04 06:01 [medline]
AID - 10.4103/0970-0358.96571 [doi]
AID - IJPS-45-16 [pii]
PST - ppublish
SO  - Indian J Plast Surg. 2012 Jan;45(1):16-21. doi: 10.4103/0970-0358.96571.


PMID- 22754084
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 0717-5906 (Print)
IS  - 0717-5906 (Linking)
VI  - 18
IP  - 1
DP  - 2012
TI  - Ethics in psychosocial and biomedical research - A training experience at the
      Interdisciplinary Center for Bioethics (CIEB) of the University of Chile().
PG  - 9-56
AB  - This paper reviews the experience in training Latin American professionals and
      scientists in the ethics of biomedical and psychosocial research at the
      Interdisciplinary Center for Studies in Bioethics (CIEB) of the University of
      Chile, aided by a grant from Fogarty International Center (FIC) - National
      Institutes of Health from 2002 to 2011. In these 10 years of experience, 50
      trainees have completed a 12-month training combining on-line and in-person
      teaching and learning activities, with further support for maintaining contact
      via webmail and personal meetings. The network formed by faculty and former
      trainees has published extensively on issues relevant in the continent and has
      been instrumental in promoting new master level courses at different
      universities, drafting regulations and norms, and promoting the use of bioethical
      discourse in health care and research. Evaluation meetings have shown that while 
      most trainees did benefit from the experience and contributed highly to
      developments at their home institutions and countries, some degree of structuring
      of demand for qualified personnel is needed in order to better utilize the human 
      resources created by the program. Publications and other deliverables of trainees
      and faculty are presented.
FAU - Lolas, Fernando
AU  - Lolas F
AD  - Director , Interdisciplinary Center for Studies in Bioethics. Professor , Dept.
      of Psychiatry, Faculty of Medicine, University of Chile, Chile. Principal
      Investigator , Grant NIH-Fogarty R25 TW6056.
FAU - Rodriguez, Eduardo
AU  - Rodriguez E
LA  - eng
GR  - R25 TW006056/TW/FIC NIH HHS/United States
PT  - Journal Article
PL  - Chile
TA  - Acta Bioeth
JT  - Acta bioethica
JID - 101259128
PMC - PMC3384684
MID - NIHMS373237
EDAT- 2012/07/04 06:00
MHDA- 2012/07/04 06:01
CRDT- 2012/07/04 06:00
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2012/07/04 06:01 [medline]
AID - 10.4067/s1726-569x2012000100002 [doi]
PST - ppublish
SO  - Acta Bioeth. 2012;18(1):9-56. doi: 10.4067/s1726-569x2012000100002.


PMID- 22753960
OWN - NLM
STAT- MEDLINE
DCOM- 20120831
LR  - 20211021
IS  - 0008-5286 (Print)
IS  - 0008-5286 (Linking)
VI  - 53
IP  - 1
DP  - 2012 Jan
TI  - An ethicist's commentary on the technician told to withhold analgesia.
PG  - 18
FAU - Rollin, Bernard E
AU  - Rollin BE
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Vet J
JT  - The Canadian veterinary journal = La revue veterinaire canadienne
JID - 0004653
RN  - 0 (Analgesics)
SB  - IM
MH  - Analgesia/economics/*veterinary
MH  - Analgesics/*administration & dosage/economics
MH  - Animals
MH  - Ethics, Professional
MH  - Humans
MH  - Pain/drug therapy/prevention & control/*veterinary
MH  - Veterinary Medicine/economics/*ethics/standards
PMC - PMC3239144
EDAT- 2012/07/04 06:00
MHDA- 2012/09/01 06:00
CRDT- 2012/07/04 06:00
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2012/09/01 06:00 [medline]
PST - ppublish
SO  - Can Vet J. 2012 Jan;53(1):18.


PMID- 22753791
OWN - NLM
STAT- MEDLINE
DCOM- 20121120
LR  - 20161020
IS  - 1526-3347 (Electronic)
IS  - 0191-9601 (Linking)
VI  - 33
IP  - 7
DP  - 2012 Jul
TI  - Ethics for the pediatrician: the evolving ethics of cochlear implants in
      children.
PG  - 323-6
LID - 10.1542/pir.33-7-323 [doi]
AB  - The story of the ethical controversy over cochlear implants is unique in some
      ways and paradigmatic in others. It is unique in the ways that it was shaped by
      the history of deafness, and of cultural responses to deafness, in the United
      States. The story is paradigmatic in two ways. First, cochlear implantation was
      an innovative therapy that was introduced into practice without adequate study.
      Promising early trials led to FDA approval, although long-term outcome data from 
      rigorous studies were lacking. In this respect, the story of cochlear implants is
      similar to the history of other innovations that were introduced without rigorous
      evaluation, innovations such as supplemental oxygen, extracorporeal membrane
      oxygenation, or corticosteroids for bronchopulmonary dysplasia. Cochlear implants
      also are paradigmatic of a particular type of ethical dilemma in which advocacy
      groups claim to know better what is best for children than do the children's
      parents or doctors. This controversy happened during the Baby Doe debate in the
      1980s, when advocacy groups claimed that doctors and parents were conspiring to
      discriminate against children with disabilities. Ultimately, the US Supreme Court
      invalidated that interpretation of disability rights. Instead, parents and
      doctors working together are given discretion to make decisions about what is
      best for children. With regard to cochlear implants for children, the NAD
      realizes that they are walking a fine line. As one NAD spokesperson said, "We
      don't say that hearing parents aren't qualified to make decisions about their
      deaf children. We say that they need to have contact with deaf people if they're 
      going to make educated decisions". The same could be said for pediatricians.
      There are 4,000 to 8,000 infants born each year in the United States with severe 
      hearing impairment. Their parents will have to make decisions about what is best.
      Pediatricians need to understand the options and be prepared to help parents sort
      through the complex data and multiple options in order to arrive at the decision 
      that is best for themselves and their child. Understanding the ethical
      controversy over cochlear implants will help.
FAU - Lantos, John D
AU  - Lantos JD
AD  - University of Missouri and Children's Mercy Bioethics Center, Children's Mercy
      Hospital, Kansas City, MO, USA.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Pediatr Rev
JT  - Pediatrics in review
JID - 8103046
SB  - IM
MH  - Child
MH  - Cochlear Implants/*ethics/history
MH  - Education of Hearing Disabled
MH  - History, 20th Century
MH  - Humans
MH  - Patient Selection
MH  - Pediatrics/*ethics
MH  - Sign Language
EDAT- 2012/07/04 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/04 06:00
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 33/7/323 [pii]
AID - 10.1542/pir.33-7-323 [doi]
PST - ppublish
SO  - Pediatr Rev. 2012 Jul;33(7):323-6. doi: 10.1542/pir.33-7-323.


PMID- 22753584
OWN - NLM
STAT- MEDLINE
DCOM- 20130322
LR  - 20120918
IS  - 1557-3265 (Electronic)
IS  - 1078-0432 (Linking)
VI  - 18
IP  - 18
DP  - 2012 Sep 15
TI  - Overestimation of the effect size in group sequential trials.
PG  - 4872-6
LID - 10.1158/1078-0432.CCR-11-3118 [doi]
AB  - Group sequential designs (GSD), which provide for interim monitoring of efficacy 
      data and allow potential early trial termination while preserving the type I
      error rate, have become commonplace in oncology clinical trials. Although
      ethically appealing, GSDs tend to overestimate the true treatment effect size at 
      early interim analyses. Overestimation of the treatment effect may exaggerate the
      benefit of a drug and provide imprecise information for physicians and their
      patients about a drug's true effect. The cause and effect of such a phenomenon
      are generally not well understood by many in clinical trial practice. In this
      article, we provide a graphical explanation for why the phenomenon of
      overestimation in GSDs occurs. The potential overestimation of the magnitude of
      the treatment effect is of particular concern in oncology, in which the more
      subjective endpoint of progression-free survival has increasingly been adopted as
      the primary endpoint in pivotal phase III trials.
CI  - (c)2012 AACR.
FAU - Zhang, Jenny J
AU  - Zhang JJ
AD  - CDER/OTS/OB/DBV, and CDER/OND/OHOP/DOP-1, U.S. Food and Drug Administration,
      Silver Spring, MD 20993, USA. jenny.zhang@fda.hhs.gov
FAU - Blumenthal, Gideon M
AU  - Blumenthal GM
FAU - He, Kun
AU  - He K
FAU - Tang, Shenghui
AU  - Tang S
FAU - Cortazar, Patricia
AU  - Cortazar P
FAU - Sridhara, Rajeshwari
AU  - Sridhara R
LA  - eng
PT  - Journal Article
DEP - 20120702
PL  - United States
TA  - Clin Cancer Res
JT  - Clinical cancer research : an official journal of the American Association for
      Cancer Research
JID - 9502500
SB  - IM
MH  - *Clinical Trials, Phase III as Topic
MH  - Humans
MH  - Neoplasms/*drug therapy
MH  - Research Design
MH  - Treatment Outcome
EDAT- 2012/07/04 06:00
MHDA- 2013/03/23 06:00
CRDT- 2012/07/04 06:00
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2013/03/23 06:00 [medline]
AID - 1078-0432.CCR-11-3118 [pii]
AID - 10.1158/1078-0432.CCR-11-3118 [doi]
PST - ppublish
SO  - Clin Cancer Res. 2012 Sep 15;18(18):4872-6. doi: 10.1158/1078-0432.CCR-11-3118.
      Epub 2012 Jul 2.


PMID- 22753459
OWN - NLM
STAT- MEDLINE
DCOM- 20120927
LR  - 20120703
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 19
IP  - 4
DP  - 2012 Jul
TI  - Pediatric consent: case study analysis using a principles approach.
PG  - 581-5
LID - 10.1177/0969733012448348 [doi]
AB  - This article will explore pediatric consent through the analysis of a clinical
      case study using the principles of biomedical ethics approach. Application of the
      principles of autonomy, nonmaleficence, beneficence, and justice will be
      dissected in order to attempt to establish resolution of the ethical dilemma. The
      main conflict in this case study deals with whether the wishes of an adolescent
      for end-of-life care should be followed or should the desire of his parents
      outweigh this request. In terminal cancer, the hope of early palliative care and 
      dignity in dying serve as priorities in therapy. Application of the moral
      principles to both sides of the dilemma aided in providing an objective
      resolution to uphold pediatric consent.
FAU - Azotam, Adaorah N U
AU  - Azotam AN
AD  - College of Nursing, Villanova University, Philadelphia, PA 19153, USA.
      Azotam@gmail.com
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
CIN - Nurs Ethics. 2012 Jul;19(4):586-7; discussion 588-9. PMID: 22753460
CIN - Nurs Ethics. 2012 Jul;19(4):587-8; discussion 588-9. PMID: 22753461
MH  - Adolescent
MH  - Beneficence
MH  - Humans
MH  - Informed Consent By Minors/*ethics
MH  - Male
MH  - Nursing Methodology Research
MH  - *Parent-Child Relations
MH  - Personal Autonomy
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/nursing/*therapy
MH  - *Resuscitation Orders
MH  - Social Justice
MH  - Terminal Care/*ethics
EDAT- 2012/07/04 06:00
MHDA- 2012/09/28 06:00
CRDT- 2012/07/04 06:00
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2012/09/28 06:00 [medline]
AID - 19/4/581 [pii]
AID - 10.1177/0969733012448348 [doi]
PST - ppublish
SO  - Nurs Ethics. 2012 Jul;19(4):581-5. doi: 10.1177/0969733012448348.


PMID- 22753458
OWN - NLM
STAT- MEDLINE
DCOM- 20120927
LR  - 20220310
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 19
IP  - 4
DP  - 2012 Jul
TI  - Including adults with intellectual disabilities who lack capacity to consent in
      research.
PG  - 558-67
LID - 10.1177/0969733011426818 [doi]
AB  - The Mental Capacity Act 2005 has stipulated that in England and Wales the ethical
      implications of carrying out research with people who are unable to consent must 
      be considered alongside the ethical implications of excluding them from research 
      altogether. This paper describes the methods that were used to enable people with
      severe and profound intellectual disabilities, who lacked capacity, to
      participate in a study that examined their experience of receiving intimate care.
      The safeguards that were put in place to protect the rights and well-being of
      participants are described, and it is argued that the approaches used in this
      study met the requirements set out in the Mental Capacity Act 2005. Although this
      paper is based on research involving people with intellectual disabilities, it
      has implications for research involving other groups who may also lack capacity
      to consent, including people with mental health problems, head injuries and
      dementia.
FAU - Calveley, Julie
AU  - Calveley J
AD  - julieclark44@yahoo.co.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Adult
MH  - Biomedical Research/*ethics/legislation & jurisprudence
MH  - Human Rights
MH  - Humans
MH  - Informed Consent/*ethics
MH  - *Intellectual Disability
MH  - *Mental Competency/legislation & jurisprudence
MH  - Nursing Methodology Research
MH  - United Kingdom
EDAT- 2012/07/04 06:00
MHDA- 2012/09/28 06:00
CRDT- 2012/07/04 06:00
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2012/09/28 06:00 [medline]
AID - 19/4/558 [pii]
AID - 10.1177/0969733011426818 [doi]
PST - ppublish
SO  - Nurs Ethics. 2012 Jul;19(4):558-67. doi: 10.1177/0969733011426818.


PMID- 22753457
OWN - NLM
STAT- MEDLINE
DCOM- 20120927
LR  - 20151119
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 19
IP  - 4
DP  - 2012 Jul
TI  - A multidimensional analysis of ethical climate, job satisfaction, organizational 
      commitment, and organizational citizenship behaviors.
PG  - 513-29
LID - 10.1177/0969733011433923 [doi]
AB  - The high turnover of nurses has become a global problem. Several studies have
      proposed that nurses' perceptions of the ethical climate of their organization
      are related to higher job satisfaction and organizational commitment and thus
      lead to higher organizational citizenship behaviors. This study uses hierarchical
      regression to understand which types of ethical climate, facets of job
      satisfaction, and the three components of organizational commitment influence
      different dimensions of organizational citizenship behaviors. Questionnaires were
      distributed to 450 nurses, and 352 usable questionnaires were returned. The
      findings of the article suggest that hospitals can increase organizational
      citizenship behaviors by influencing an organization's ethical climate, job
      satisfaction, and organizational commitment. Hospital administrators can foster
      within organizations, the climate types of caring, law and code and rules
      climate, satisfaction with coworkers, and affective commitment and normative
      commitment that increase organizational citizenship behavior, while preventing
      organizations from developing the type of instrumental climate and continuance
      commitment that decreases it.
FAU - Huang, Chun-Chen
AU  - Huang CC
AD  - Department of International Business, Asia University, Lioufeng Rd.,Wufeng,
      Taichung 41354, Taiwan. cchuang1127@gmail.com
FAU - You, Ching-Sing
AU  - You CS
FAU - Tsai, Ming-Tien
AU  - Tsai MT
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - *Ethics, Institutional
MH  - Female
MH  - Humans
MH  - *Job Satisfaction
MH  - Male
MH  - Multivariate Analysis
MH  - Nursing Methodology Research
MH  - Nursing Staff, Hospital/*psychology
MH  - Organizational Culture
MH  - *Personnel Loyalty
MH  - *Social Behavior
MH  - Surveys and Questionnaires
MH  - Taiwan
MH  - Young Adult
EDAT- 2012/07/04 06:00
MHDA- 2012/09/28 06:00
CRDT- 2012/07/04 06:00
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2012/09/28 06:00 [medline]
AID - 19/4/513 [pii]
AID - 10.1177/0969733011433923 [doi]
PST - ppublish
SO  - Nurs Ethics. 2012 Jul;19(4):513-29. doi: 10.1177/0969733011433923.


PMID- 22753456
OWN - NLM
STAT- MEDLINE
DCOM- 20120927
LR  - 20120703
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 19
IP  - 4
DP  - 2012 Jul
TI  - Ethics and compromised consciousness.
PG  - 449-50
LID - 10.1177/0969733012449782 [doi]
FAU - Gallagher, Ann
AU  - Gallagher A
LA  - eng
PT  - Editorial
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Consciousness/*ethics
MH  - *Ethics, Nursing
MH  - Humans
MH  - Unconsciousness/nursing
EDAT- 2012/07/04 06:00
MHDA- 2012/09/28 06:00
CRDT- 2012/07/04 06:00
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2012/09/28 06:00 [medline]
AID - 19/4/449 [pii]
AID - 10.1177/0969733012449782 [doi]
PST - ppublish
SO  - Nurs Ethics. 2012 Jul;19(4):449-50. doi: 10.1177/0969733012449782.


PMID- 22753455
OWN - NLM
STAT- MEDLINE
DCOM- 20130716
LR  - 20211021
IS  - 1718-4304 (Electronic)
IS  - 0896-8608 (Linking)
VI  - 33
IP  - 1
DP  - 2013 Jan-Feb
TI  - Using a multidisciplinary training program to reduce peritonitis in peritoneal
      dialysis patients.
PG  - 38-45
LID - 10.3747/pdi.2011.00109 [doi]
AB  - OBJECTIVES: The present study evaluated the tool used to assess patients' skills 
      and the impact on peritonitis rates of a new multidisciplinary peritoneal
      dialysis (PD) education program (PDEP). METHODS: After the University Hospital
      Ethics Committee approved the study, the educational and clinical records of PD
      patients were retrospectively analyzed in two phases. In phase I, an Objective
      Structured Assessment (OSA) was used during August 2008 to evaluate the practical
      skills of 25 patients with adequate Kt/V and no mental disabilities who had been 
      on PD for more than 1 month. Test results were correlated with the prior year's
      peritonitis rate. In phase II, the new PDEP, consisting of individual lessons, a 
      retraining schedule, and group meetings, was introduced starting 1 September
      2008. Age, sex, years of education, time on PD, number of training sessions, and 
      peritonitis episodes were recorded. Statistical analyses used t-tests, chi-square
      tests, and Poisson distributions; a p value of less than 0.05 was considered
      significant. RESULTS: In phase I, 25 patients [16 men, 9 women; mean age: 54 +/- 
      15 years (range: 22 - 84 years); mean time on PD: 35 +/- 30 months (range: 1 -
      107 months)] were studied. The OSA results correlated with peritonitis rates:
      patients who passed the test had experienced significantly lower peritonitis
      rates during the prior year (p < 0.05). In phase II, after the new PDEP was
      introduced, overall peritonitis rates significantly declined (to 0.28
      episodes/patient-year from 0.55 episodes/patient-year, p < 0.05); the
      Staphylococcus peritonitis rate also declined (to 0.09 episodes/patient-year from
      0.24 episodes/patient-year, p < 0.05). CONCLUSIONS: The OSA is a reliable tool
      for assessing patients' skills, and it correlates with peritonitis rates. The
      multidisciplinary PDEP significantly improved outcomes by further lowering
      peritonitis rates.
FAU - Gadola, Liliana
AU  - Gadola L
AD  - Centro de Nefrologia, Hospital de Clinicas, Universidad de la Republica, Uruguay.
      lilianagad@gmail.com
FAU - Poggi, Carla
AU  - Poggi C
FAU - Poggio, Maria
AU  - Poggio M
FAU - Saez, Lucia
AU  - Saez L
FAU - Ferrari, Alejandra
AU  - Ferrari A
FAU - Romero, Jorge
AU  - Romero J
FAU - Fumero, Soledad
AU  - Fumero S
FAU - Ghelfi, Gianella
AU  - Ghelfi G
FAU - Chifflet, Liliana
AU  - Chifflet L
FAU - Borges, Patricia Larre
AU  - Borges PL
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20120701
PL  - United States
TA  - Perit Dial Int
JT  - Peritoneal dialysis international : journal of the International Society for
      Peritoneal Dialysis
JID - 8904033
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Educational Status
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Morbidity/trends
MH  - Patient Education as Topic/*methods
MH  - Peritoneal Dialysis/*adverse effects
MH  - Peritonitis/epidemiology/etiology/*prevention & control
MH  - *Program Evaluation
MH  - Retrospective Studies
MH  - Survival Rate/trends
MH  - Uruguay/epidemiology
MH  - Young Adult
PMC - PMC3598264
EDAT- 2012/07/04 06:00
MHDA- 2013/07/17 06:00
CRDT- 2012/07/04 06:00
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2013/07/17 06:00 [medline]
AID - pdi.2011.00109 [pii]
AID - 10.3747/pdi.2011.00109 [doi]
PST - ppublish
SO  - Perit Dial Int. 2013 Jan-Feb;33(1):38-45. doi: 10.3747/pdi.2011.00109. Epub 2012 
      Jul 1.


PMID- 22753181
OWN - NLM
STAT- MEDLINE
DCOM- 20120807
LR  - 20120927
IS  - 0303-7339 (Print)
IS  - 0303-7339 (Linking)
VI  - 54
IP  - 6
DP  - 2012
TI  - [The ethical duty to treat children and adolescents with autism and catatonia].
PG  - 493-5
FAU - Sienaert, P
AU  - Sienaert P
LA  - dut
PT  - Editorial
TT  - Behandeling van jongeren met autisme en katatonie: ethische plicht.
PL  - Netherlands
TA  - Tijdschr Psychiatr
JT  - Tijdschrift voor psychiatrie
JID - 0423731
SB  - IM
CIN - Tijdschr Psychiatr. 2012;54(9):843-4; author reply 844. PMID: 22961283
MH  - Adolescent
MH  - Autistic Disorder/*therapy
MH  - Catatonia/*therapy
MH  - Child
MH  - Child Psychiatry/*ethics
MH  - *Ethics, Clinical
MH  - Humans
EDAT- 2012/07/04 06:00
MHDA- 2012/08/08 06:00
CRDT- 2012/07/04 06:00
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2012/08/08 06:00 [medline]
AID - TVPart_9392 [pii]
PST - ppublish
SO  - Tijdschr Psychiatr. 2012;54(6):493-5.


PMID- 22752704
OWN - NLM
STAT- MEDLINE
DCOM- 20131112
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 18
IP  - 3
DP  - 2012 Sep
TI  - Biological indeterminacy.
PG  - 447-52
LID - 10.1007/s11948-012-9379-2 [doi]
AB  - Reductionist explanations in biology generally assume that biological mechanisms 
      are highly deterministic and basically similar between individuals. A contrasting
      view has emerged recently that takes into account the degeneracy of biological
      processes--the ability to arrive at a given endpoint by a variety of available
      paths, even within the same individual. This perspective casts significant doubt 
      on the prospects for the ability to predict behavior accurately based on brain
      imaging or genotyping, and on the ability of neuroscience to stipulate ethics.
FAU - Greenspan, Ralph J
AU  - Greenspan RJ
AD  - Kavli Institute for Brain and Mind, University of California San Diego, La Jolla,
      CA, USA. rgreenspan@ucsd.edu
LA  - eng
PT  - Journal Article
DEP - 20120703
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
CIN - Sci Eng Ethics. 2012 Sep;18(3):453-6. PMID: 22695816
MH  - *Brain
MH  - *Genotype
MH  - Humans
MH  - *Models, Biological
MH  - *Morals
MH  - Neuroimaging
MH  - Neurosciences/*ethics
MH  - Psychophysiology/*ethics
MH  - *Social Behavior
EDAT- 2012/07/04 06:00
MHDA- 2013/11/13 06:00
CRDT- 2012/07/04 06:00
PHST- 2008/03/15 00:00 [received]
PHST- 2012/05/25 00:00 [accepted]
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2013/11/13 06:00 [medline]
AID - 10.1007/s11948-012-9379-2 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2012 Sep;18(3):447-52. doi: 10.1007/s11948-012-9379-2. Epub 2012 
      Jul 3.


PMID- 22752550
OWN - NLM
STAT- MEDLINE
DCOM- 20130103
LR  - 20211021
IS  - 1873-4626 (Electronic)
IS  - 1091-255X (Linking)
VI  - 16
IP  - 9
DP  - 2012 Sep
TI  - Identification of anomolous biliary anatomy using near-infrared cholangiography.
PG  - 1814-5
LID - 10.1007/s11605-012-1945-z [doi]
AB  - BACKGROUND: Intraoperative cholangiography (IOC) is especially helpful for the
      detection of anomalous biliary anatomy during laparoscopic cholecystectomy.
      Fluorescent cholangiography using an intravenously injected fluorophore and
      near-infrared (NIR) imaging provides similar anatomical detail to standard
      radiographic cholangiography without ionizing radiation, puncture of the biliary 
      system, or additional operative time. This video shows a laparoscopic
      cholecystectomy performed under NIR cholangiographic guidance and highlights its 
      ability to identify anomalous anatomy. METHODS: The attached video shows a
      laparoscopic cholecystectomy being performed on a 28-year-old female with a
      history of biliary colic and ultrasonographic evidence of cholelithiasis. This
      patient agreed to be part of a larger randomized study looking at near-infrared
      cholangiography and its ability to prevent common bile duct injuries (approved by
      the ethics review board of our institution and registered with clinicaltrials.gov
      Identifier# NCT01424215). This study uses the Pinpoint system (Novadaq, Ontario, 
      Canada) for NIR imaging (Fig. 1). The Pinpoint mates a high definition white
      light laparoscopic view to the NIR cholangiography, providing an uninterrupted,
      augmented view of the anatomy. 1 cm(3) of indocyanine green was injected
      intravenously prior to the procedure. RESULTS: As shown in the video, an
      anomalous duct was identified during dissection and development of the critical
      view of safety. Because of the possibility that this represented an aberrant
      right hepatic duct, the cystic duct was controlled and divided distal to the
      anomalous duct and the gall bladder excised from the fossa in the usual manner.
      The patient did well without sequelae at 1 week and 1 month follow-up.
      CONCLUSION: Anomolous ductal anatomy of the biliary tree has been reported in up 
      to 23 % of cases.1,2 The ability of IOC to elucidate biliary anatomy and thus
      prevent bile duct injury has led many to espouse routine cholangiography for all 
      laparoscopic cholecystectomies.3,4 Near-infrared cholangiography (NIRC) is easy
      to perform, does not add steps to the operative procedure, and produces a similar
      anatomic roadmap of the hepatocystic triangle to that of standard IOC. Although
      the clinical significance of the anomalous duct identified in this video is
      unknown, this video highlights the excellent detail provided by NIRC.
      Recommendations regarding the routine use of this new technology await the
      results of an ongoing randomized control study.
FAU - Sherwinter, Danny A
AU  - Sherwinter DA
AD  - Division of Minimally Invasive Surgery, Maimonides Medical Center, 4802 10th
      avenue, Brooklyn, NY 11219, USA. dsherwinter@maimonidesmed.org
LA  - eng
SI  - ClinicalTrials.gov/NCT01424215
PT  - Case Reports
PT  - Journal Article
PT  - Video-Audio Media
DEP - 20120703
PL  - United States
TA  - J Gastrointest Surg
JT  - Journal of gastrointestinal surgery : official journal of the Society for Surgery
      of the Alimentary Tract
JID - 9706084
SB  - IM
MH  - Adult
MH  - Bile Ducts/*abnormalities
MH  - Cholangiography/*methods
MH  - Cholecystectomy, Laparoscopic/*methods
MH  - Cholelithiasis/*diagnostic imaging/surgery
MH  - Female
MH  - Humans
MH  - Intraoperative Period
EDAT- 2012/07/04 06:00
MHDA- 2013/01/04 06:00
CRDT- 2012/07/04 06:00
PHST- 2012/04/01 00:00 [received]
PHST- 2012/06/15 00:00 [accepted]
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2013/01/04 06:00 [medline]
AID - 10.1007/s11605-012-1945-z [doi]
PST - ppublish
SO  - J Gastrointest Surg. 2012 Sep;16(9):1814-5. doi: 10.1007/s11605-012-1945-z. Epub 
      2012 Jul 3.


PMID- 22752490
OWN - NLM
STAT- MEDLINE
DCOM- 20130123
LR  - 20211021
IS  - 1708-8283 (Electronic)
IS  - 0883-0738 (Linking)
VI  - 27
IP  - 9
DP  - 2012 Sep
TI  - Cardiac transplantation in Friedreich ataxia.
PG  - 1193-6
LID - 10.1177/0883073812448229 [doi]
AB  - In this article, we describe a 14-year-old boy with a confirmed diagnosis of
      Friedreich ataxia who underwent cardiac transplantation for left ventricular
      failure secondary to dilated cardiomyopathy with restrictive physiology. His
      neurological status prior to transplantation reflected early signs of
      neurological disease, with evidence of dysarthria, weakness, mild gait
      impairment, and limb ataxia. We review the ethical issues considered during the
      process leading to the decision to offer cardiac transplantation.
FAU - Yoon, Grace
AU  - Yoon G
AD  - Division of Clinical and Metabolic Genetics, Department of Pediatrics, The
      Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
      grace.yoon@utoronto.ca
FAU - Soman, Teesta
AU  - Soman T
FAU - Wilson, Judith
AU  - Wilson J
FAU - George, Kristen
AU  - George K
FAU - Mital, Seema
AU  - Mital S
FAU - Dipchand, Anne I
AU  - Dipchand AI
FAU - McCabe, Jane
AU  - McCabe J
FAU - Logan, William
AU  - Logan W
FAU - Kantor, Paul
AU  - Kantor P
LA  - eng
GR  - R13 NS040925/NS/NINDS NIH HHS/United States
GR  - 2R13NS040925-14/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120629
PL  - United States
TA  - J Child Neurol
JT  - Journal of child neurology
JID - 8606714
SB  - IM
MH  - Friedreich Ataxia/*complications
MH  - Heart Diseases/*etiology/*surgery
MH  - Heart Transplantation/*methods
MH  - Humans
PMC - PMC3671892
MID - NIHMS473277
EDAT- 2012/07/04 06:00
MHDA- 2013/01/24 06:00
CRDT- 2012/07/04 06:00
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2013/01/24 06:00 [medline]
AID - 0883073812448229 [pii]
AID - 10.1177/0883073812448229 [doi]
PST - ppublish
SO  - J Child Neurol. 2012 Sep;27(9):1193-6. doi: 10.1177/0883073812448229. Epub 2012
      Jun 29.


PMID- 22752441
OWN - NLM
STAT- MEDLINE
DCOM- 20130524
LR  - 20211021
IS  - 1432-1084 (Electronic)
IS  - 0938-7994 (Linking)
VI  - 22
IP  - 12
DP  - 2012 Dec
TI  - A comparison of MR elastography and 31P MR spectroscopy with histological staging
      of liver fibrosis.
PG  - 2790-7
LID - 10.1007/s00330-012-2527-x [doi]
AB  - OBJECTIVES: Conventional imaging techniques are insensitive to liver fibrosis.
      This study assesses the diagnostic accuracy of MR elastography (MRE) stiffness
      values and the ratio of phosphomonoesters (PME)/phosphodiesters (PDE) measured
      using (31)P spectroscopy against histological fibrosis staging. METHODS: The
      local research ethics committee approved this prospective, blinded study. A total
      of 77 consecutive patients (55 male, aged 49 +/- 11.5 years) with a clinical
      suspicion of liver fibrosis underwent an MR examination with a liver biopsy later
      the same day. Patients underwent MRE and (31)P spectroscopy on a 1.5 T whole body
      system. The liver biopsies were staged using an Ishak score for chronic hepatitis
      or a modified NAS fibrosis score for fatty liver disease. RESULTS: MRE increased 
      with and was positively associated with fibrosis stage (Spearman's rank = 0.622, 
      P < 0.001). PME/PDE was not associated with fibrosis stage (Spearman's rank =
      -0.041, p = 0.741). Area under receiver operating curves for MRE stiffness values
      were high (range 0.75-0.97). The diagnostic utility of PME/PDE was no better than
      chance (range 0.44-0.58). CONCLUSIONS: MRE-estimated liver stiffness increases
      with fibrosis stage and is able to dichotomise fibrosis stage groupings. We did
      not find a relationship between (31)P MR spectroscopy and fibrosis stage. KEY
      POINTS: Magnetic resonance elastography (MRE) and MR spectroscopy can both assess
      the liver. MRE is superior to ( 31 ) P MR spectroscopy in staging hepatic
      fibrosis. MRE is able to dichotomise liver fibrosis stage groupings.
      Gradient-echo MRE may be problematic in genetic haemochromatosis.
FAU - Godfrey, Edmund M
AU  - Godfrey EM
AD  - St James' Hospital, Beckett Street, Leeds, LS9 7TF, UK.
      edmund.godfrey@leedsth.nhs.uk
FAU - Patterson, Andrew J
AU  - Patterson AJ
FAU - Priest, Andrew N
AU  - Priest AN
FAU - Davies, Susan E
AU  - Davies SE
FAU - Joubert, Ilse
AU  - Joubert I
FAU - Krishnan, Anant S
AU  - Krishnan AS
FAU - Griffin, Nyree
AU  - Griffin N
FAU - Shaw, Ashley S
AU  - Shaw AS
FAU - Alexander, Graeme J
AU  - Alexander GJ
FAU - Allison, Michael E
AU  - Allison ME
FAU - Griffiths, William J H
AU  - Griffiths WJ
FAU - Gimson, Alexander E S
AU  - Gimson AE
FAU - Lomas, David J
AU  - Lomas DJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120701
PL  - Germany
TA  - Eur Radiol
JT  - European radiology
JID - 9114774
SB  - IM
MH  - Biopsy
MH  - Elasticity Imaging Techniques/*methods
MH  - Female
MH  - Humans
MH  - Liver Cirrhosis/*pathology
MH  - Magnetic Resonance Spectroscopy/*methods
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - ROC Curve
EDAT- 2012/07/04 06:00
MHDA- 2013/05/28 06:00
CRDT- 2012/07/04 06:00
PHST- 2012/01/17 00:00 [received]
PHST- 2012/04/01 00:00 [accepted]
PHST- 2012/03/22 00:00 [revised]
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2013/05/28 06:00 [medline]
AID - 10.1007/s00330-012-2527-x [doi]
PST - ppublish
SO  - Eur Radiol. 2012 Dec;22(12):2790-7. doi: 10.1007/s00330-012-2527-x. Epub 2012 Jul
      1.


PMID- 22752257
OWN - NLM
STAT- MEDLINE
DCOM- 20121211
LR  - 20211021
IS  - 1433-0431 (Electronic)
IS  - 0085-4530 (Linking)
VI  - 41
IP  - 7
DP  - 2012 Jul
TI  - [Physical therapy as part of a complex orthopedic rheumatology approach.
      Physiotherapy, cryotherapy, extracorporeal shockwave lithotripsy, local
      intra-articular joint injections].
PG  - 520-5
LID - 10.1007/s00132-012-1929-4 [doi]
AB  - In this review only some of the physical therapeutic options for treating chronic
      inflammatory diseases are discussed. These include a wide variety of procedures
      and should not exclusively be assessed using the criteria of evidence-based
      medicine because in most studies there was no blinding or for ethical reasons no 
      placebo group was included. Nevertheless, these treatment options are quite
      essential as part of a multimodal treatment concept for patients with
      inflammatory joint diseases. The increasing interest in adjuvant therapeutic
      options emphasizes the need for further well designed studies concerning the
      effectiveness of physical therapy. Dynamic exercise is closely integrated into
      the treatment strategy for rheumatoid arthritis. In addition to a conditioning
      stimulus to joints and cartilage it is known that physical therapy is useful in
      preventing mechanisms of disease chronification. Locally applied and whole body
      cryotherapy leads to muscular relaxation resulting in a more effective treatment 
      intensity of subsequent exercise. With extracorporeal shockwave therapy (ESWT) a 
      new promising therapeutic approach is available. However, the evidence level is
      still weak when used for patients with rheumatoid arthritis. Locally applied
      steroid injections still have a significant value when treating inflammatory
      synovial conditions.
FAU - Arnold, I
AU  - Arnold I
AD  - Klinik fur operative Rheumatologie und Orthopadie, Rheuma-Zentrum Bremen,
      Rotes-Kreuz-Krankenhaus Bremen gGmbH, St.-Pauli-Deich 24, 28199, Bremen,
      Deutschland. arnold.i@roteskreuzkrankenhaus.de
FAU - Guttke, T
AU  - Guttke T
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Physikalische Therapie im Kontext orthopadischer Rheumatologie. Physiotherapie,
      Kryotherapie, ESWL, lokale Injektionen.
PL  - Germany
TA  - Orthopade
JT  - Der Orthopade
JID - 0331266
RN  - 0 (Antirheumatic Agents)
RN  - 0 (Steroids)
SB  - IM
MH  - Antirheumatic Agents/*therapeutic use
MH  - Arthritis, Rheumatoid/*therapy
MH  - Combined Modality Therapy
MH  - Cryotherapy/*methods
MH  - Evidence-Based Medicine
MH  - Exercise Therapy/*methods
MH  - Humans
MH  - Injections, Intra-Articular
MH  - Lithotripsy/*methods
MH  - Steroids/*administration & dosage
MH  - Treatment Outcome
EDAT- 2012/07/04 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/07/04 06:00
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - 10.1007/s00132-012-1929-4 [doi]
PST - ppublish
SO  - Orthopade. 2012 Jul;41(7):520-5. doi: 10.1007/s00132-012-1929-4.


PMID- 22752004
OWN - NLM
STAT- MEDLINE
DCOM- 20130117
LR  - 20120809
IS  - 1464-3790 (Electronic)
IS  - 0967-0742 (Linking)
VI  - 20
IP  - 3
DP  - 2012 Summer
TI  - Medical confidentiality and partner notification in cases of sexually
      transmissible infections in Belgium.
PG  - 399-422
LID - 10.1093/medlaw/fws010 [doi]
AB  - Research has shown that HIV-positive patients sometimes refuse to take
      precautionary measures against sexual transmission as well as to notify their
      sexual partner(s) of their status. Faced with such a situation, physicians find
      themselves in a dilemma as they are forced to choose between honouring their duty
      of professional confidentiality and protecting their patients' partner(s). Recent
      advice from the Belgian Medical Council (BMC) for the first time accepts that
      physicians can exceptionally, and under certain conditions, invoke necessity to
      breach confidentiality and inform usual and occasional sexual partners of
      HIV-infected patients who refuse to take precautions against transmission. This
      article sketches the ethical evolution of this position from 1987 up to now in
      Belgium, and examines whether or not the BMC's opinion on the matter corresponds 
      to the applicable substantive criminal law provisions and whether or not partner 
      notification could also be defended for other sexually transmissible infections
      (STIs). A case study of the situation in Belgium illustrates how discussions
      about STIs can deeply influence the evolution of legal and ethical rules about
      medical confidentiality.
FAU - Ketels, Bjorn
AU  - Ketels B
AD  - Ghent University, Belgium. tom.vanderbeken@ugent.be
FAU - Vander Beken, Tom
AU  - Vander Beken T
LA  - eng
PT  - Journal Article
DEP - 20120629
PL  - England
TA  - Med Law Rev
JT  - Medical law review
JID - 9308945
SB  - IM
MH  - Belgium
MH  - Confidentiality/*legislation & jurisprudence
MH  - Contact Tracing/*ethics/*legislation & jurisprudence
MH  - Duty to Warn/ethics/legislation & jurisprudence
MH  - HIV Seropositivity
MH  - Humans
MH  - *Sexually Transmitted Diseases
EDAT- 2012/07/04 06:00
MHDA- 2013/01/18 06:00
CRDT- 2012/07/04 06:00
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2013/01/18 06:00 [medline]
AID - fws010 [pii]
AID - 10.1093/medlaw/fws010 [doi]
PST - ppublish
SO  - Med Law Rev. 2012 Summer;20(3):399-422. doi: 10.1093/medlaw/fws010. Epub 2012 Jun
      29.


PMID- 22751985
OWN - NLM
STAT- MEDLINE
DCOM- 20121211
LR  - 20190709
IS  - 1943-4723 (Electronic)
IS  - 0002-8177 (Linking)
VI  - 143
IP  - 7
DP  - 2012 Jul
TI  - What are the ethical obligations of a dentist who suspects that his or her
      partner may be impaired by an addiction to pain medication?
PG  - 795-6
FAU - Henner, Kevin A
AU  - Henner KA
AD  - Dental Association Council on Ethics, Bylaws and Judicial Affairs, 211 E. Chicago
      Ave., Chicago, IL 60611, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Am Dent Assoc
JT  - Journal of the American Dental Association (1939)
JID - 7503060
RN  - 0 (Analgesics, Opioid)
SB  - IM
MH  - American Dental Association
MH  - Analgesics, Opioid/therapeutic use
MH  - Chronic Pain/*drug therapy
MH  - Codes of Ethics
MH  - *Ethics, Dental
MH  - Humans
MH  - Partnership Practice, Dental/*ethics
MH  - *Prescription Drug Misuse
MH  - *Professional Impairment
MH  - United States
EDAT- 2012/07/04 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/07/04 06:00
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - S0002-8177(14)61130-2 [pii]
AID - 10.14219/jada.archive.2012.0272 [doi]
PST - ppublish
SO  - J Am Dent Assoc. 2012 Jul;143(7):795-6. doi: 10.14219/jada.archive.2012.0272.


PMID- 22751956
OWN - NLM
STAT- MEDLINE
DCOM- 20141020
LR  - 20181202
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 40
IP  - 3
DP  - 2014 Mar
TI  - Commentary on Simon Rippon, 'Imposing options on people in poverty: the harm of a
      live donor organ market'.
PG  - 153-4
LID - 10.1136/medethics-2012-100646 [doi]
FAU - Walsh, Adrian
AU  - Walsh A
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20120629
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
CON - J Med Ethics. 2014 Mar;40(3):145-50. PMID: 22745109
CIN - J Med Ethics. 2014 Mar;40(3):155-6. PMID: 23129816
MH  - Commerce/*ethics
MH  - *Decision Making
MH  - Humans
MH  - *Living Donors
MH  - Paternalism/*ethics
MH  - *Personal Autonomy
MH  - *Poverty
MH  - *Social Justice
MH  - Tissue and Organ Procurement/*ethics
MH  - *Vulnerable Populations
OTO - NOTNLM
OT  - Ethics
OT  - commodification
OT  - ethical methodology
OT  - thought experiments
EDAT- 2012/07/04 06:00
MHDA- 2014/10/21 06:00
CRDT- 2012/07/04 06:00
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2014/10/21 06:00 [medline]
AID - medethics-2012-100646 [pii]
AID - 10.1136/medethics-2012-100646 [doi]
PST - ppublish
SO  - J Med Ethics. 2014 Mar;40(3):153-4. doi: 10.1136/medethics-2012-100646. Epub 2012
      Jun 29.


PMID- 22751876
OWN - NLM
STAT- MEDLINE
DCOM- 20120918
LR  - 20211021
IS  - 1538-3628 (Electronic)
IS  - 1072-4710 (Linking)
VI  - 166
IP  - 7
DP  - 2012 Jul 1
TI  - Sugaring the pill: ethics and uncertainties in the use of sucrose for newborn
      infants.
PG  - 629-33
LID - 10.1001/archpediatrics.2012.352 [doi]
AB  - Sucrose is widely used for the management of procedural pain in newborn infants, 
      including capillary blood sampling, venepuncture, and vascular cannulation.
      Multiple randomized controlled trials have demonstrated that sweet-tasting
      solutions reduce behavioral responses to acute painful stimuli. It has been
      claimed that sucrose should be a standard of care in neonatal units and that
      further placebo-controlled trials of sucrose are unnecessary and unethical.
      However, recently published data cast doubt on the analgesic properties of
      sucrose. We review this new evidence and analyze the philosophical and ethical
      questions that it raises, including the "problem of other minds." Sugar may be
      better understood not as an analgesic, removing or relieving pain, but as a
      compensating pleasure. There is a need for further research on the mechanism of
      sucrose's effect on pain behavior and on the long-term effects of sucrose
      treatment. Such trials will require comparison with placebo or with other
      interventions. Given uncertainty about the benefit of sucrose, it may be wise to 
      use alternative analgesics or nonpharmacological interventions where these are
      available and appropriate. Sucrose may not be the answer to procedural pain in
      newborns.
FAU - Wilkinson, Dominic J C
AU  - Wilkinson DJ
AD  - The Robinson Institute, Discipline of Obstetrics and Gynecology, University of
      Adelaide, Adelaide, Australia. dominic.wilkinson@adelaide.edu.au
FAU - Savulescu, Julian
AU  - Savulescu J
FAU - Slater, Rebeccah
AU  - Slater R
LA  - eng
GR  - Wellcome Trust/United Kingdom
GR  - 086041/Wellcome Trust/United Kingdom
GR  - 090245/WT_/Wellcome Trust/United Kingdom
GR  - 086041/Z/08/Z/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Arch Pediatr Adolesc Med
JT  - Archives of pediatrics & adolescent medicine
JID - 9422751
RN  - 0 (Analgesics)
RN  - 0 (Sweetening Agents)
RN  - 57-50-1 (Sucrose)
SB  - IM
CIN - Arch Pediatr Adolesc Med. 2012 Jul 1;166(7):667-9. PMID: 22751887
MH  - Administration, Oral
MH  - Analgesics/*administration & dosage
MH  - Blood Specimen Collection/*ethics
MH  - Humans
MH  - Infant, Newborn
MH  - Pain/diagnosis/*drug therapy/etiology
MH  - Pain Measurement
MH  - Sucrose/*administration & dosage
MH  - Sweetening Agents/administration & dosage
PMC - PMC3430849
MID - UKMS49376
OID - NLM: UKMS49376
EDAT- 2012/07/04 06:00
MHDA- 2012/09/19 06:00
CRDT- 2012/07/04 06:00
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2012/09/19 06:00 [medline]
AID - 1212229 [pii]
AID - 10.1001/archpediatrics.2012.352 [doi]
PST - ppublish
SO  - Arch Pediatr Adolesc Med. 2012 Jul 1;166(7):629-33. doi:
      10.1001/archpediatrics.2012.352.


PMID- 22751727
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20190911
IS  - 1984-0446 (Electronic)
IS  - 0034-7167 (Linking)
VI  - 65
IP  - 1
DP  - 2012 Jan-Feb
TI  - [Brazilian nursing and the democratization of health: notes on the National
      Policy of Popular Education in Health].
PG  - 179-85
LID - S0034-71672012000100026 [pii]
AB  - This essay discusses the role of Brazilian nursing as a socially committed
      practice, in the political and pedagogic plan. The concepts of popular
      participation, representative and participatory democracy, and education in
      health are recovered, enlightened by the recent history of the constitution of
      social network of practices and reflections called Popular Education and Health. 
      The construction process and the ethical-political principles of a National
      Policy of Popular Education in Health are presented, discussing the participation
      of nursing in the changes of educational practices, in spaces of political
      representation and formulation of public policies, with a perspective of
      achieving a fair and equal social order.
FAU - David, Helena Maria Scherlowski Leal
AU  - David HM
AD  - Departamento de Enfermagem de Saude Publica, Faculdade de Enfermagem,
      Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brasil.
      helena.david@uol.com.br
FAU - Bonetti, Osvaldo Peralta
AU  - Bonetti OP
FAU - da Silva, Maria Rocineide Ferreira
AU  - da Silva MR
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - A Enfermagem Brasileira e a democratizacao da saude: notas sobre a Politica
      Nacional de Educacao Popular em Saude.
PL  - Brazil
TA  - Rev Bras Enferm
JT  - Revista brasileira de enfermagem
JID - 7910105
MH  - Brazil
MH  - *Democracy
MH  - *Health Education
MH  - *Health Policy
MH  - Humans
MH  - *Nursing
EDAT- 2012/07/04 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/04 06:00
PHST- 2011/02/11 00:00 [received]
PHST- 2012/03/02 00:00 [accepted]
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - S0034-71672012000100026 [pii]
AID - 10.1590/s0034-71672012000100026 [doi]
PST - ppublish
SO  - Rev Bras Enferm. 2012 Jan-Feb;65(1):179-85. doi: 10.1590/s0034-71672012000100026.


PMID- 22751553
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20190201
IS  - 2384-8553 (Electronic)
IS  - 0021-2571 (Linking)
VI  - 48
IP  - 2
DP  - 2012
TI  - Common criteria among States for storage and use of dried blood spot specimens
      after newborn screening.
PG  - 119-21
LID - 10.4415/ANN_12_02_03 [doi]
AB  - Biological samples collected in biobanks are a resource with significant research
      potential. The Italian Joint Group CNB - CNBBSV (National Committee of Bioethics 
      - National Committee for Biosecurity, Biotechnologies and Life Sciences)
      published a document reporting recommendations on storage and use of dried blood 
      spot (DBS) and on the development of a National Network of Regional Newborn
      Screening Repositories for collection of residual DBS. Several ethical questions 
      (about consent, possible use of genetic information, unanticipated possible
      usages for research purposes) rise from residual newborn screening specimens
      collections. Moreover, legal and ethical controversies are accentuated by the
      conflicts between the interests of sample donors, biobank holders, researchers
      and the public. To overcome these difficulties the identification of a few
      criteria for storage and research usage of DBS is crucial.
FAU - Petrini, Carlo
AU  - Petrini C
AD  - Unita di Bioetica, Presidenza, Istituto Superiore di Sanita, Rome, Italy.
      carlo.petrini@iss.it
FAU - Olivieri, Antonella
AU  - Olivieri A
FAU - Corbetta, Carlo
AU  - Corbetta C
FAU - Cerone, Roberto
AU  - Cerone R
FAU - D'Agnolo, Giuliano
AU  - D'Agnolo G
FAU - Bompiani, Adriano
AU  - Bompiani A
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Ann Ist Super Sanita
JT  - Annali dell'Istituto superiore di sanita
JID - 7502520
SB  - IM
MH  - Academies and Institutes/organization & administration
MH  - Biological Specimen Banks/ethics/organization & administration/*standards
MH  - Blood Preservation/ethics/methods/*standards
MH  - Blood Specimen Collection/ethics/methods/*standards
MH  - Desiccation
MH  - Genetic Privacy/*standards
MH  - *Genetic Testing/ethics/methods
MH  - Humans
MH  - Infant, Newborn
MH  - Italy
MH  - *Mandatory Testing/ethics/methods
MH  - Minnesota
MH  - *Neonatal Screening/ethics/methods
MH  - Parental Consent
MH  - Professional-Family Relations
MH  - Specimen Handling/standards
EDAT- 2012/07/04 06:00
MHDA- 2012/11/14 06:00
CRDT- 2012/07/04 06:00
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
AID - 10.4415/ANN_12_02_03 [doi]
PST - ppublish
SO  - Ann Ist Super Sanita. 2012;48(2):119-21. doi: 10.4415/ANN_12_02_03.


PMID- 22751516
OWN - NLM
STAT- MEDLINE
DCOM- 20120911
LR  - 20181201
IS  - 1528-1140 (Electronic)
IS  - 0003-4932 (Linking)
VI  - 256
IP  - 1
DP  - 2012 Jul
TI  - Responding to patient requests to withdraw life support: surgical ethics and
      responsibility.
PG  - 16-7
LID - 10.1097/SLA.0b013e31825b6a42 [doi]
FAU - Angelos, Peter
AU  - Angelos P
LA  - eng
PT  - Editorial
PT  - Comment
PL  - United States
TA  - Ann Surg
JT  - Annals of surgery
JID - 0372354
SB  - IM
CON - Ann Surg. 2012 Jul;256(1):10-5. PMID: 22584696
MH  - Female
MH  - *General Surgery
MH  - Humans
MH  - *Life Support Care
MH  - Male
MH  - *Medical Errors
MH  - Withholding Treatment/*statistics & numerical data
EDAT- 2012/07/04 06:00
MHDA- 2012/09/12 06:00
CRDT- 2012/07/04 06:00
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2012/09/12 06:00 [medline]
AID - 10.1097/SLA.0b013e31825b6a42 [doi]
AID - 00000658-201207000-00004 [pii]
PST - ppublish
SO  - Ann Surg. 2012 Jul;256(1):16-7. doi: 10.1097/SLA.0b013e31825b6a42.


PMID- 22751177
OWN - NLM
STAT- MEDLINE
DCOM- 20130220
LR  - 20200325
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Linking)
VI  - 32
IP  - 1
DP  - 2012
TI  - Convection-enhanced delivery of neprilysin: a novel amyloid-beta-degrading
      therapeutic strategy.
PG  - 43-56
AB  - Enzymatic degradation contributes to the control of intracerebral amyloid-beta
      (Abeta) peptide levels. Previous studies have demonstrated the therapeutic
      potential of viral vector-mediated neprilysin (NEP) gene therapy in mouse models 
      of Alzheimer's disease (AD). However, clinical translation of NEP gene therapy is
      limited by ethical and practical considerations. In this study we have assessed
      the potential of convection-enhanced delivery (CED) as a means of elevating
      intracerebral NEP level and activity and degrading endogenous Abeta. We analyzed 
      the interstitial and perivascular distribution of NEP following CED into rat
      striatum. We measured NEP protein level, clearance, activity, and toxicity by
      ELISA for NEP and synaptophysin, NEP-specific activity assay, and
      immunohistochemistry for NEP, NeuN, glial fibrillary acidic protein and Iba1. We 
      subsequently performed CED of NEP in normal aged rats and measured endogenous
      Abeta by ELISA. CED resulted in widespread distribution of NEP, and a 20-fold
      elevation of NEP protein level with preservation of enzyme activity and without
      evidence of toxicity. CED in normal, aged rats resulted in a significant
      reduction in endogenous Abeta(40) (p = 0.04), despite rapid NEP clearance from
      the brain (half-life ~3 h). CED of NEP has therapeutic potential as a dynamically
      controllable Abeta(40)-degrading therapeutic strategy for AD. Further studies are
      required to determine the longer term effects on Abeta (including Abeta(42)) and 
      on cognitive function.
FAU - Barua, Neil U
AU  - Barua NU
AD  - Functional Neurosurgery Research Group, University of Bristol, Bristol, UK.
FAU - Miners, J Scott
AU  - Miners JS
FAU - Bienemann, Alison S
AU  - Bienemann AS
FAU - Wyatt, Marcella J
AU  - Wyatt MJ
FAU - Welser, Katharina
AU  - Welser K
FAU - Tabor, Alethea B
AU  - Tabor AB
FAU - Hailes, Helen C
AU  - Hailes HC
FAU - Love, Seth
AU  - Love S
FAU - Gill, Steven S
AU  - Gill SS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
RN  - 0 (Aif1 protein, rat)
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Antigens, Nuclear)
RN  - 0 (Calcium Channel Blockers)
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Microfilament Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Pharmaceutical Vehicles)
RN  - 0 (Rbfox3 protein, rat)
RN  - 0 (Synaptophysin)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 57WA9QZ5WH (Nimodipine)
RN  - EC 3.4.24.11 (Neprilysin)
SB  - IM
MH  - Aging/physiology
MH  - Alzheimer Disease/*drug therapy/metabolism
MH  - Amyloid beta-Peptides/*metabolism
MH  - Animals
MH  - Antigens, Nuclear/metabolism
MH  - Calcium Channel Blockers/pharmacology
MH  - Calcium-Binding Proteins/metabolism
MH  - Catheterization
MH  - Dose-Response Relationship, Drug
MH  - Drug Delivery Systems
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Glial Fibrillary Acidic Protein/metabolism
MH  - Immunohistochemistry
MH  - Male
MH  - Microfilament Proteins/metabolism
MH  - Neprilysin/*administration & dosage/pharmacokinetics/*therapeutic use
MH  - Nerve Tissue Proteins/metabolism
MH  - Neuroimaging
MH  - Nimodipine/pharmacology
MH  - Pharmaceutical Vehicles
MH  - Polyethylene Glycols
MH  - Rats
MH  - Rats, Wistar
MH  - Synaptophysin/metabolism
EDAT- 2012/07/04 06:00
MHDA- 2013/02/21 06:00
CRDT- 2012/07/04 06:00
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2013/02/21 06:00 [medline]
AID - 065X06RR40QQ8180 [pii]
AID - 10.3233/JAD-2012-120658 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2012;32(1):43-56. doi: 10.3233/JAD-2012-120658.


PMID- 22750752
OWN - NLM
STAT- MEDLINE
DCOM- 20121016
LR  - 20151119
IS  - 1879-3185 (Electronic)
IS  - 0300-483X (Linking)
VI  - 301
IP  - 1-3
DP  - 2012 Nov 15
TI  - Evidence for nevirapine bioactivation in man: searching for the first step in the
      mechanism of nevirapine toxicity.
PG  - 33-9
LID - 10.1016/j.tox.2012.06.013 [doi]
AB  - Despite its efficacy, including in the prevention of vertical transmission, the
      antiretroviral nevirapine is associated with severe idiosyncratic hepatotoxicity 
      and skin rash. The mechanisms underlying nevirapine toxicity are not fully
      understood, but drug bioactivation to reactive metabolites capable of forming
      stable protein adducts is thought to be involved. This hypothesis is based on the
      paradigm that drug reactive metabolites have the potential to bind to
      self-proteins, which results in drug-modified proteins being perceived as foreign
      by the immune system. The aim of the present work was to identify hemoglobin
      adducts in HIV patients as biomarkers of nevirapine haptenation upon
      bioactivation. The ultimate goal is to develop diagnostic methods for predicting 
      the onset of nevirapine-induced toxic reactions. All included subjects were
      adults on nevirapine-containing antiretroviral therapy for at least 1month. The
      protocol received prior approval from the Hospital Ethics Committees and patients
      gave their written informed consent. Nevirapine-derived adducts with the
      N-terminal valine of hemoglobin were analyzed by an established liquid
      chromatography-electrospray ionization-tandem mass spectrometry method and
      characterized on the basis of retention time and mass spectrometric fragmentation
      pattern by comparison with adduct standards prepared synthetically. The
      nevirapine adducts were detected in 12/13 patient samples, and quantified in
      11/12 samples (2.58+/-0.8 fmol/g of hemoglobin). This work represents the first
      evidence of nevirapine-protein adduct formation in man and confirms the ability
      of nevirapine to modify self-proteins, thus providing clues to the molecular
      mechanisms underlying nevirapine toxicity. Moreover, the possibility of assessing
      nevirapine-protein adduct levels has the potential to become useful for
      predicting the onset of nevirapine-induced adverse reactions.
CI  - Copyright (c) 2012. Published by Elsevier Ireland Ltd.
FAU - Caixas, Umbelina
AU  - Caixas U
AD  - Centro de Estudos de Doencas Cronicas, Universidade NOVA 1169-056 Lisboa,
      Portugal.
FAU - Antunes, Alexandra M M
AU  - Antunes AM
FAU - Marinho, Aline T
AU  - Marinho AT
FAU - Godinho, Ana L A
AU  - Godinho AL
FAU - Grilo, Nadia M
AU  - Grilo NM
FAU - Marques, M Matilde
AU  - Marques MM
FAU - Oliveira, M Conceicao
AU  - Oliveira MC
FAU - Branco, Teresa
AU  - Branco T
FAU - Monteiro, Emilia C
AU  - Monteiro EC
FAU - Pereira, Sofia A
AU  - Pereira SA
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120628
PL  - Ireland
TA  - Toxicology
JT  - Toxicology
JID - 0361055
RN  - 0 (Anti-HIV Agents)
RN  - 0 (Biomarkers)
RN  - 0 (Haptens)
RN  - 0 (Hemoglobins)
RN  - 0 (Proteins)
RN  - 99DK7FVK1H (Nevirapine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anti-HIV Agents/adverse effects/*pharmacokinetics/therapeutic use
MH  - Biomarkers/metabolism
MH  - Case-Control Studies
MH  - Chromatography, Liquid
MH  - Female
MH  - HIV Infections/*drug therapy
MH  - Haptens/metabolism
MH  - Hemoglobins/*metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nevirapine/adverse effects/*pharmacokinetics/therapeutic use
MH  - Proteins/metabolism
MH  - Spectrometry, Mass, Electrospray Ionization
MH  - Tandem Mass Spectrometry
EDAT- 2012/07/04 06:00
MHDA- 2012/10/17 06:00
CRDT- 2012/07/04 06:00
PHST- 2012/05/02 00:00 [received]
PHST- 2012/06/19 00:00 [revised]
PHST- 2012/06/20 00:00 [accepted]
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2012/10/17 06:00 [medline]
AID - S0300-483X(12)00243-0 [pii]
AID - 10.1016/j.tox.2012.06.013 [doi]
PST - ppublish
SO  - Toxicology. 2012 Nov 15;301(1-3):33-9. doi: 10.1016/j.tox.2012.06.013. Epub 2012 
      Jun 28.


PMID- 22750457
OWN - NLM
STAT- MEDLINE
DCOM- 20121126
LR  - 20181201
IS  - 1758-1117 (Electronic)
IS  - 0023-6772 (Linking)
VI  - 46
IP  - 3
DP  - 2012 Jul
TI  - Reponse to Pfister R, Gyger M, Bugnon P, et al. Editorial ethical guidelines:
      what about the evaluation of the benefits to humans?
PG  - 265-6
LID - 10.1258/la.2012.012047 [doi]
FAU - Dunn, C S
AU  - Dunn CS
FAU - Flecknell, P A
AU  - Flecknell PA
FAU - Morris, T
AU  - Morris T
LA  - eng
PT  - Letter
PT  - Comment
DEP - 20120702
PL  - England
TA  - Lab Anim
JT  - Laboratory animals
JID - 0112725
SB  - IM
CON - Lab Anim. 2012 Jul;46(3):264-5. PMID: 22723646
MH  - Animal Welfare/*standards
MH  - Animals
MH  - *Animals, Laboratory
MH  - *Bioethical Issues
MH  - *Editorial Policies
MH  - Humans
MH  - *Practice Guidelines as Topic
MH  - *Social Change
EDAT- 2012/07/04 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/04 06:00
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - la.2012.012047 [pii]
AID - 10.1258/la.2012.012047 [doi]
PST - ppublish
SO  - Lab Anim. 2012 Jul;46(3):265-6. doi: 10.1258/la.2012.012047. Epub 2012 Jul 2.


PMID- 22749745
OWN - NLM
STAT- MEDLINE
DCOM- 20130103
LR  - 20220330
IS  - 1943-7811 (Electronic)
IS  - 1525-1578 (Linking)
VI  - 14
IP  - 5
DP  - 2012 Sep
TI  - A new technology for stabilization of biomolecules in tissues for combined
      histological and molecular analyses.
PG  - 458-66
LID - 10.1016/j.jmoldx.2012.05.002 [doi]
AB  - For accurate diagnosis, prediction of outcome, and selection of appropriate
      therapies, the molecular characterization of human diseases requires analysis of 
      a broad spectrum of altered biomolecules, in addition to morphological features, 
      in affected tissues such as tumors. In a high-throughput screening approach, we
      have developed the PAXgene Tissue System as a novel tissue stabilization
      technology. Comprehensive characterization of this technology in stabilized and
      paraffin-embedded human tissues and comparison with snap-frozen tissues revealed 
      excellent preservation of morphology and antigenicity, as well as outstanding
      integrity of nucleic acids (genomic DNA, miRNA, and mRNA) and phosphoproteins.
      Importantly, PAXgene-fixed, paraffin-embedded tissues provided RNA quantity and
      quality not only significantly better than that obtained with neutral buffered
      formalin, but also similar to that from snap-frozen tissue, which currently
      represents the gold standard for molecular analyses. The PAXgene tissue
      stabilization system thus opens new opportunities in a variety of molecular
      diagnostic and research applications in which the collection of snap-frozen
      tissue is not feasible for medical, logistic, or ethical reasons. Furthermore,
      this technology allows performing histopathological analyses together with
      molecular studies in a single sample, which markedly facilitates direct
      correlation of morphological disease phenotypes with alterations of nucleic acids
      and other biomolecules.
CI  - Copyright (c) 2012 American Society for Investigative Pathology and the
      Association for Molecular Pathology. Published by Elsevier Inc. All rights
      reserved.
FAU - Viertler, Christian
AU  - Viertler C
AD  - Institute of Pathology, Medical University of Graz, Graz, Austria.
FAU - Groelz, Daniel
AU  - Groelz D
FAU - Gundisch, Sibylle
AU  - Gundisch S
FAU - Kashofer, Karl
AU  - Kashofer K
FAU - Reischauer, Bilge
AU  - Reischauer B
FAU - Riegman, Peter H J
AU  - Riegman PH
FAU - Winther, Rosa
AU  - Winther R
FAU - Wyrich, Ralf
AU  - Wyrich R
FAU - Becker, Karl-Friedrich
AU  - Becker KF
FAU - Oelmuller, Uwe
AU  - Oelmuller U
FAU - Zatloukal, Kurt
AU  - Zatloukal K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120628
PL  - United States
TA  - J Mol Diagn
JT  - The Journal of molecular diagnostics : JMD
JID - 100893612
RN  - 0 (Nucleic Acids)
RN  - 0 (Proteins)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Nucleic Acids/metabolism
MH  - Proteins/metabolism
MH  - Specimen Handling/*methods
MH  - Tissue Preservation/*methods
EDAT- 2012/07/04 06:00
MHDA- 2013/01/04 06:00
CRDT- 2012/07/04 06:00
PHST- 2012/01/12 00:00 [received]
PHST- 2012/05/08 00:00 [revised]
PHST- 2012/05/10 00:00 [accepted]
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2013/01/04 06:00 [medline]
AID - S1525-1578(12)00121-3 [pii]
AID - 10.1016/j.jmoldx.2012.05.002 [doi]
PST - ppublish
SO  - J Mol Diagn. 2012 Sep;14(5):458-66. doi: 10.1016/j.jmoldx.2012.05.002. Epub 2012 
      Jun 28.


PMID- 22749493
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20190429
IS  - 1873-5223 (Electronic)
IS  - 1471-5953 (Linking)
VI  - 12
IP  - 5
DP  - 2012 Sep
TI  - Developing midwifery practice through work-based learning: an exploratory study.
PG  - 273-8
LID - 10.1016/j.nepr.2012.06.003 [doi]
AB  - AIM: To explore what effect the introduction of a Work-Based Learning Module
      undertaken by midwives in a range of maternity settings has had on their personal
      professional development, as well as the impact on developing local maternity and
      neonatal care provision. METHODOLOGY: A case study approach was used consisting
      of mixed methods. Quantitative data were collected through questionnaires from
      midwives and their Clinical Supervisors at the end of the module, with a survey
      questionnaire to each midwifery manager, six months following the implementation 
      of the midwives' project in practice. Qualitative data were collected by focus
      groups at six different work place locations, with health professionals who had
      experienced the midwives' projects within the workplace. Quantitative data were
      manually analysed whereas content analysis was used to identify recurrent themes 
      from the qualitative data, with the support of Computer Assisted Qualitative Data
      Analysis Software. The University of Nottingham granted ethical approval for the 
      study. PARTICIPANTS AND SETTING: Twelve midwives who undertook the work-based
      module, their respective Clinical Supervisors (n = 12), their employers/managers 
      (n = 12) and health professionals (n = 28) within six individual National Health 
      Service Trusts in the East Midlands of the United Kingdom took part in the study.
      FINDINGS: The work-based learning module not only led to the personal and
      professional development of the midwife, but also to improving multi-professional
      collaboration and the consequential development of maternity services within the 
      local Trusts. The value of leading change by completing an innovative and
      tangible work-based project through a flexible mode of study strengthened the
      midwives' clinical credibility among colleagues and employers and supports the
      philosophy of inter-professional learning and working. IMPLICATIONS FOR PRACTICE:
      This novel Work Based approach to learning has the potential to further develop
      the provision of post-registration education for midwives and other health
      professionals, as it helps to bridge the theory-practice gap. Learning in the
      workplace is efficient and cost effective to employee and employer and serves in 
      increasing the link between higher education and the workplace. Furthermore, as
      the principles of work-based learning could be transferred to other contexts
      outside of the United Kingdom, such an approach has the potential to directly
      influence the development of global midwifery education and maternity services
      and ultimately benefit mothers, their babies and families throughout the world.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Marshall, Jayne E
AU  - Marshall JE
AD  - University of Nottingham, Faculty of Medicine and Health Sciences, School of
      Nursing, Midwifery and Physiotherapy, Academic Division of Midwifery, Nottingham 
      University Hospitals NHS Trust (City Campus), Hucknall Road, Nottingham NG5 1PB, 
      UK. jayne.marshall@nottingham.ac.uk
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120630
PL  - Scotland
TA  - Nurse Educ Pract
JT  - Nurse education in practice
JID - 101090848
SB  - IM
MH  - Female
MH  - Focus Groups
MH  - Humans
MH  - *Inservice Training
MH  - *Learning
MH  - Midwifery/*organization & administration
MH  - Nurse Midwives/*education/psychology
MH  - Nursing Education Research
MH  - Nursing Evaluation Research
MH  - Pregnancy
MH  - Qualitative Research
MH  - Staff Development/*methods
MH  - Surveys and Questionnaires
MH  - United Kingdom
EDAT- 2012/07/04 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/04 06:00
PHST- 2011/11/15 00:00 [received]
PHST- 2012/05/15 00:00 [revised]
PHST- 2012/06/06 00:00 [accepted]
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - S1471-5953(12)00113-8 [pii]
AID - 10.1016/j.nepr.2012.06.003 [doi]
PST - ppublish
SO  - Nurse Educ Pract. 2012 Sep;12(5):273-8. doi: 10.1016/j.nepr.2012.06.003. Epub
      2012 Jun 30.


PMID- 22749488
OWN - NLM
STAT- MEDLINE
DCOM- 20130108
LR  - 20120730
IS  - 1769-664X (Electronic)
IS  - 0929-693X (Linking)
VI  - 19
IP  - 8
DP  - 2012 Aug
TI  - [Publication ethics are ignored: the integrity of science is in danger].
PG  - 879-81
LID - 10.1016/j.arcped.2012.05.006 [doi]
FAU - Maisonneuve, H
AU  - Maisonneuve H
LA  - fre
PT  - Letter
TT  - L'ethique des publications est ignoree : cela nuit a l'integrite de la science.
DEP - 20120629
PL  - France
TA  - Arch Pediatr
JT  - Archives de pediatrie : organe officiel de la Societe francaise de pediatrie
JID - 9421356
SB  - IM
CIN - Arch Pediatr. 2012 Nov;19(11):1262-3. PMID: 23037579
MH  - Conflict of Interest
MH  - Editorial Policies
MH  - *Ethics, Research
MH  - Humans
MH  - Plagiarism
MH  - *Publishing
MH  - Research Support as Topic
MH  - *Scientific Misconduct
EDAT- 2012/07/04 06:00
MHDA- 2013/01/09 06:00
CRDT- 2012/07/04 06:00
PHST- 2012/05/20 00:00 [received]
PHST- 2012/05/23 00:00 [accepted]
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2013/01/09 06:00 [medline]
AID - S0929-693X(12)00236-9 [pii]
AID - 10.1016/j.arcped.2012.05.006 [doi]
PST - ppublish
SO  - Arch Pediatr. 2012 Aug;19(8):879-81. doi: 10.1016/j.arcped.2012.05.006. Epub 2012
      Jun 29.


PMID- 22749442
OWN - NLM
STAT- MEDLINE
DCOM- 20121128
LR  - 20220129
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 75
IP  - 8
DP  - 2012 Oct
TI  - Investigating the potential for ethnic group harm in collaborative genomics
      research in Africa: is ethnic stigmatisation likely?
PG  - 1400-7
LID - 10.1016/j.socscimed.2012.05.020 [doi]
AB  - A common assumption in genomics research is that the use of ethnic categories has
      the potential to lead to ethnic stigmatisation - particularly when the research
      is done on minority populations. Yet few empirical studies have sought to
      investigate the relation between genomics and stigma, and fewer still with a
      focus on Africa. In this paper, we investigate the potential for genomics
      research to lead to harms to ethnic groups. We carried out 49 semi-structured,
      open-ended interviews with stakeholders in a current medical genomics research
      project in Africa, MalariaGEN. Interviews were conducted with MalariaGEN
      researchers, fieldworkers, members of three ethics committees who reviewed
      MalariaGEN project proposals, and with members of the two funding bodies
      providing support to the MalariaGEN project. Interviews were conducted in Kenya, 
      The Gambia and the UK between June 2008 and October 2009. They covered a range of
      aspects relating to the use of ethnicity in the genomics project, including views
      on adverse effects of the inclusion of ethnicity in such research. Drawing on the
      empirical data, we argue that the risk of harm to ethnic groups is likely to be
      more acute in specific types of genomics research. We develop a typology of
      research questions and projects that carry a greater risk of harm to the
      populations included in genomics research. We conclude that the potential of
      generating harm to ethnic groups in genomics research is present if research
      includes populations that are already stigmatised or discriminated against, or
      where the research investigates questions with particular normative implications.
      We identify a clear need for genomics researchers to take account of the social
      context of the work they are proposing to do, including understanding the local
      realities and relations between ethnic groups, and whether diseases are already
      stigmatised.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - de Vries, Jantina
AU  - de Vries J
AD  - The Ethox Centre, Department of Public Health, University of Oxford, UK.
      Jantina.devries@uct.ac.za
FAU - Jallow, Muminatou
AU  - Jallow M
FAU - Williams, Thomas N
AU  - Williams TN
FAU - Kwiatkowski, Dominic
AU  - Kwiatkowski D
FAU - Parker, Michael
AU  - Parker M
FAU - Fitzpatrick, Raymond
AU  - Fitzpatrick R
LA  - eng
GR  - 096527/Wellcome Trust/United Kingdom
GR  - 091758/Wellcome Trust/United Kingdom
GR  - 083326/Wellcome Trust/United Kingdom
GR  - 075491/Z/04/WT_/Wellcome Trust/United Kingdom
GR  - G0600718/MRC_/Medical Research Council/United Kingdom
GR  - (G0600230/MRC_/Medical Research Council/United Kingdom
GR  - 075491/Wellcome Trust/United Kingdom
GR  - G0600230/MRC_/Medical Research Council/United Kingdom
GR  - WT077383/Z/05/Z/WT_/Wellcome Trust/United Kingdom
GR  - 090532/Wellcome Trust/United Kingdom
GR  - 077012/Z/05/Z/WT_/Wellcome Trust/United Kingdom
GR  - 092654/Wellcome Trust/United Kingdom
GR  - 076934/Wellcome Trust/United Kingdom
GR  - 077012/Wellcome Trust/United Kingdom
GR  - 077383/Wellcome Trust/United Kingdom
GR  - G19/9/MRC_/Medical Research Council/United Kingdom
GR  - G0600230(77610)/MRC_/Medical Research Council/United Kingdom
GR  - 087285/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120616
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Africa
MH  - Cooperative Behavior
MH  - Ethnicity/genetics/*psychology
MH  - *Genetic Research
MH  - Genome-Wide Association Study
MH  - *Genomics
MH  - Humans
MH  - Malaria/ethnology/genetics
MH  - Qualitative Research
MH  - Risk Assessment
MH  - *Stereotyping
PMC - PMC3632260
MID - EMS52843
OID - NLM: EMS52843
EDAT- 2012/07/04 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/04 06:00
PHST- 2011/07/13 00:00 [received]
PHST- 2012/03/28 00:00 [revised]
PHST- 2012/05/11 00:00 [accepted]
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - S0277-9536(12)00448-0 [pii]
AID - 10.1016/j.socscimed.2012.05.020 [doi]
PST - ppublish
SO  - Soc Sci Med. 2012 Oct;75(8):1400-7. doi: 10.1016/j.socscimed.2012.05.020. Epub
      2012 Jun 16.


PMID- 22748982
OWN - NLM
STAT- MEDLINE
DCOM- 20120925
LR  - 20120703
IS  - 1097-6752 (Electronic)
IS  - 0889-5406 (Linking)
VI  - 142
IP  - 1
DP  - 2012 Jul
TI  - Ethics in orthodontics. You can lead a horse to water, but...
PG  - 4
LID - 10.1016/j.ajodo.2012.03.019 [doi]
FAU - Greco, Peter M
AU  - Greco PM
LA  - eng
PT  - Editorial
PL  - United States
TA  - Am J Orthod Dentofacial Orthop
JT  - American journal of orthodontics and dentofacial orthopedics : official
      publication of the American Association of Orthodontists, its constituent
      societies, and the American Board of Orthodontics
JID - 8610224
SB  - IM
MH  - Adolescent
MH  - Adolescent Behavior/ethics
MH  - Choice Behavior/ethics
MH  - Cooperative Behavior
MH  - Dentist-Patient Relations/*ethics
MH  - *Ethics, Dental
MH  - Humans
MH  - Orthodontics/*ethics
MH  - *Personal Autonomy
EDAT- 2012/07/04 06:00
MHDA- 2012/09/26 06:00
CRDT- 2012/07/04 06:00
PHST- 2012/03/28 00:00 [received]
PHST- 2012/03/28 00:00 [revised]
PHST- 2012/03/30 00:00 [accepted]
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2012/09/26 06:00 [medline]
AID - S0889-5406(12)00365-4 [pii]
AID - 10.1016/j.ajodo.2012.03.019 [doi]
PST - ppublish
SO  - Am J Orthod Dentofacial Orthop. 2012 Jul;142(1):4. doi:
      10.1016/j.ajodo.2012.03.019.


PMID- 22748849
OWN - NLM
STAT- MEDLINE
DCOM- 20131227
LR  - 20121126
IS  - 1578-147X (Electronic)
IS  - 0009-739X (Linking)
VI  - 90
IP  - 10
DP  - 2012 Dec
TI  - [Use of fibrin based biological adhesives in the prevention of anastomotic leaks 
      in the high risk digestive tract: preliminary results of the multicentre,
      prospective, randomised, controlled, and simple blind phase IV clinical trial:
      Protissucol001].
PG  - 647-55
LID - 10.1016/j.ciresp.2012.05.007 [doi]
LID - S0009-739X(12)00191-1 [pii]
AB  - INTRODUCTION: A multicentre, prospective, randomised, controlled, and simple
      blind clinical trial was started in January 2007, with the aim of demonstrating
      the efficacy of fibrin-based biological adhesives in the prevention of
      anastomotic leaks in the high risk digestive tract. MATERIAL AND METHODS: A study
      on the prevention of anastomotic healing defects by applying biological adhesives
      along the suture line began in January 2007, and included the hospitals, Gregorio
      Maranon, Universitario de San Carlos, and Hospital del Sureste, in Madrid. The
      enrolled patients were randomised to one of 2 groups: the study group in which
      the adhesive was applied to the suture line, and a control group in which it was 
      not applied. The primary outcome of the study was the presence or absence of
      leaks. The trial was approved by the corresponding Clinical Research Ethics
      Committees and the Spanish Medicines Agency (AEMPS) and registered
      www.clinicaltrials.gov (NCT01306851). The authors declared not to have any
      conflict of interests with the company, Baxter, which markets the product in
      Spain. RESULTS: A total of 104 patients were recruited between January 2007 and
      November 2010, of whom 52 were randomised to the study group, and 52 to the
      control group. A total of 22 anastomotic leaks were recorded, of which 7 (13.4%) 
      were in the study group, and 15 (28.8%) in the control group (P=.046). The leak
      risk index was 0.384, which means that there was a 61% reduction in leaks in the 
      patients who had the fibrin-based biological adhesive applied. There were 3
      (5.7%) further surgeries in the study group, compared to 12 (23%) in the control 
      group (P=.12). On analysing the mortality, it was observed that 3 patients in the
      study group and 4 patients in the control group died (5.7% vs. 7.7%, P=.5). No
      other significant differences were found as regards the type of suture, surgical 
      time, or pre-surgical history, except that the use of drainages appeared to be a 
      protective factor of anastomotic leak (P=.041), although the use or not of a
      drainage was not a controlled factor, but at the discretion of each surgeon.
      CONCLUSIONS: Our study demonstrates, significantly, that in the 104 patients in
      the study that fibrin based biological adhesives are capable of preventing
      anastomotic leaks in the high risk digestive tract, reducing the risk of leaks by
      61% and a further surgeries. This is the first clinical trial that shows these
      significant results. If our results are maintained at the end of the study, it
      will show that anastomotic leaks can be prevented with the application of these
      adhesives, thus their application may be recommended in all the anastomosis of
      the high risk digestive tract.
CI  - Copyright (c) 2011 AEC. Published by Elsevier Espana. All rights reserved.
FAU - Lago Oliver, Jesus
AU  - Lago Oliver J
AD  - Hospital General Universitario Gregorio Maranon, Madrid, Espana.
      jesus.lago@salud.madrid.org
FAU - Arjona Medina, Irene
AU  - Arjona Medina I
FAU - Martin Garcia-Almenta, Ester
AU  - Martin Garcia-Almenta E
FAU - Martin Gil, Jorge
AU  - Martin Gil J
FAU - Sanz Sanchez, Mercedes
AU  - Sanz Sanchez M
FAU - Perez Diaz, Maria Dolores
AU  - Perez Diaz MD
FAU - Alonso Poza, Alfredo
AU  - Alonso Poza A
FAU - Turegano Fuentes, Fernando
AU  - Turegano Fuentes F
FAU - Torres Garcia, Antonio
AU  - Torres Garcia A
LA  - spa
SI  - ClinicalTrials.gov/NCT01306851
PT  - Clinical Trial, Phase IV
PT  - English Abstract
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
TT  - Utilizacion de adhesivos biologicos a base de fibrina en la prevencion de fugas
      anastomoticas en anastomosis del tubo digestivo de alto riesgo: resultados
      preliminares del ensayo clinico fase iv multicentrico, prospectivo, aleatorizado 
      y controlado simple ciego: Protissucol001.
DEP - 20120627
PL  - Spain
TA  - Cir Esp
JT  - Cirugia espanola
JID - 1254104
RN  - 0 (Biocompatible Materials)
RN  - 0 (Fibrin Tissue Adhesive)
RN  - 0 (Tissue Adhesives)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anastomotic Leak/*prevention & control
MH  - Biocompatible Materials
MH  - Female
MH  - *Fibrin Tissue Adhesive
MH  - Gastrointestinal Tract
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Risk Factors
MH  - Sutures
MH  - *Tissue Adhesives
EDAT- 2012/07/04 06:00
MHDA- 2013/12/29 06:00
CRDT- 2012/07/04 06:00
PHST- 2011/09/20 00:00 [received]
PHST- 2012/04/14 00:00 [revised]
PHST- 2012/05/07 00:00 [accepted]
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2013/12/29 06:00 [medline]
AID - S0009-739X(12)00191-1 [pii]
AID - 10.1016/j.ciresp.2012.05.007 [doi]
PST - ppublish
SO  - Cir Esp. 2012 Dec;90(10):647-55. doi: 10.1016/j.ciresp.2012.05.007. Epub 2012 Jun
      27.


PMID- 22748809
OWN - NLM
STAT- MEDLINE
DCOM- 20121024
LR  - 20220316
IS  - 1557-8399 (Electronic)
IS  - 0065-3527 (Linking)
VI  - 83
DP  - 2012
TI  - Clinical aspects of phage therapy.
PG  - 73-121
LID - 10.1016/B978-0-12-394438-2.00003-7 [doi]
AB  - Phage therapy (PT) is a unique method of treatment of bacterial infections using 
      bacteriophages (phages)-viruses that specifically kill bacteria, including their 
      antibiotic-resistant strains. Over the last decade a marked increase in interest 
      in the therapeutic use of phages has been observed, which has resulted from a
      substantial rise in the prevalence of antibiotic resistance of bacteria, coupled 
      with an inadequate number of new antibiotics. The first, and so far the only,
      center of PT in the European Union is the Phage Therapy Unit (PTU) established at
      the Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Wroclaw,
      Poland in 2005. This center continues the rich tradition of PT in Poland, which
      dates from the early 1920s. The main objective of this chapter is to present a
      detailed retrospective analysis of the results of PT of 153 patients with a wide 
      range of infections resistant to antibiotic therapy admitted for treatment at the
      PTU between January 2008 and December 2010. Analysis includes the evaluation of
      both the efficacy and the safety of PT. In general, data suggest that PT can
      provide good clinical results in a significant cohort of patients with otherwise 
      untreatable chronic bacterial infections and is essentially well tolerated. In
      addition, the whole complex procedure employed to obtain and characterize
      therapeutic phage preparations, as well as ethical aspects of PT, is discussed.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Miedzybrodzki, Ryszard
AU  - Miedzybrodzki R
AD  - Bacteriophage Laboratory, Ludwik Hirszfeld Institute of Immunology Experimental
      Therapy, Polish Academy of Sciences, Wroclaw, Poland. mbrodzki@iitd.pan.wroc.pl
FAU - Borysowski, Jan
AU  - Borysowski J
FAU - Weber-Dabrowska, Beata
AU  - Weber-Dabrowska B
FAU - Fortuna, Wojciech
AU  - Fortuna W
FAU - Letkiewicz, Slawomir
AU  - Letkiewicz S
FAU - Szufnarowski, Krzysztof
AU  - Szufnarowski K
FAU - Pawelczyk, Zdzislaw
AU  - Pawelczyk Z
FAU - Rogoz, Pawel
AU  - Rogoz P
FAU - Klak, Marlena
AU  - Klak M
FAU - Wojtasik, Elzbieta
AU  - Wojtasik E
FAU - Gorski, Andrzej
AU  - Gorski A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Adv Virus Res
JT  - Advances in virus research
JID - 0370441
RN  - 0 (Biological Products)
SB  - IM
MH  - Bacterial Infections/*therapy
MH  - Bacteriophages/enzymology/*growth & development
MH  - Biological Products/adverse effects/*therapeutic use
MH  - Biological Therapy/adverse effects/*methods
MH  - Biomedical Research/methods/standards
MH  - Chronic Disease
MH  - Complementary Therapies/adverse effects/*methods
MH  - Humans
MH  - Poland
MH  - Retrospective Studies
MH  - Treatment Outcome
EDAT- 2012/07/04 06:00
MHDA- 2012/10/25 06:00
CRDT- 2012/07/04 06:00
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2012/10/25 06:00 [medline]
AID - B978-0-12-394438-2.00003-7 [pii]
AID - 10.1016/B978-0-12-394438-2.00003-7 [doi]
PST - ppublish
SO  - Adv Virus Res. 2012;83:73-121. doi: 10.1016/B978-0-12-394438-2.00003-7.


PMID- 22748529
OWN - NLM
STAT- MEDLINE
DCOM- 20120904
LR  - 20191210
IS  - 1555-9823 (Electronic)
IS  - 0003-1348 (Linking)
VI  - 78
IP  - 7
DP  - 2012 Jul
TI  - Use of the medical Ethics Consultation Service in a busy Level I trauma center:
      impact on decision-making and patient care.
PG  - 735-40
AB  - The purposes of this study were to assess reasons for consultation of the Ethics 
      Consultation Service for trauma patients and how consultations impacted care. We 
      conducted a review of ethics consultations at a Level I trauma center from 2001
      to 2010. Data included patient demographics, etiology of injury, and timing/type 
      of the consult, categorized as: shared decision-making, end-of-life, privacy and 
      confidentiality, resource allocation, and professionalism. Consultations were
      requested on 108 patients (age mean, 46.5 +/- 20 years; Injury Severity Score
      mean, 23 +/- 14; length of stay [LOS] mean, 44 +/- 44 days), 0.50 per cent of all
      trauma admissions. Seventy-seven per cent of consultations occurred in the
      intensive care unit. End of life was the most common consultation (44%) followed 
      by shared decision-making (41%). Average time to consultation was 25 days. Shared
      decision-making consults occurred much earlier than end-of-life consults as
      evidenced by a lower consult day/LOS ratio (consult day/LOS = 0.36 +/- 0.3 vs
      0.77 +/- 0.3, P = 0.0001). Conclusions consisted of: 1) ethics consultation on
      trauma patients are most commonly for end-of-life and shared decision-making
      issues; 2) most ethics consultations occur while patients are in the intensive
      care unit; and 3) earlier ethics consultations are likely to be for shared
      decision-making issues.
FAU - Johnson, Laura S
AU  - Johnson LS
AD  - Department of Surgery, Emory University, Atlanta, Georgia, USA.
      laurasjohnson@alumni.usc.edu
FAU - Lesandrini, Jason
AU  - Lesandrini J
FAU - Rozycki, Grace S
AU  - Rozycki GS
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - United States
TA  - Am Surg
JT  - The American surgeon
JID - 0370522
SB  - IM
MH  - Adult
MH  - Aged
MH  - Confidentiality/ethics
MH  - Decision Making/*ethics
MH  - *Ethics Consultation/statistics & numerical data
MH  - Female
MH  - Georgia
MH  - Humans
MH  - Intensive Care Units/ethics
MH  - Male
MH  - Middle Aged
MH  - Patient Care/*ethics
MH  - Patient Participation
MH  - Resource Allocation/ethics
MH  - Retrospective Studies
MH  - Terminal Care/ethics
MH  - Trauma Centers/*ethics
EDAT- 2012/07/04 06:00
MHDA- 2012/09/05 06:00
CRDT- 2012/07/04 06:00
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2012/09/05 06:00 [medline]
PST - ppublish
SO  - Am Surg. 2012 Jul;78(7):735-40.


PMID- 22747971
OWN - NLM
STAT- MEDLINE
DCOM- 20130107
LR  - 20220331
IS  - 1472-6963 (Electronic)
IS  - 1472-6963 (Linking)
VI  - 12
DP  - 2012 Jul 2
TI  - Factors associated with patterns of plural healthcare utilization among patients 
      taking antiretroviral therapy in rural and urban South Africa: a cross-sectional 
      study.
PG  - 182
LID - 10.1186/1472-6963-12-182 [doi]
AB  - BACKGROUND: In low-resource settings, patients' use of multiple healthcare
      sources may complicate chronic care and clinical outcomes as antiretroviral
      therapy (ART) continues to expand. However, little is known regarding patterns,
      drivers and consequences of using multiple healthcare sources. We therefore
      investigated factors associated with patterns of plural healthcare usage among
      patients taking ART in diverse South African settings. METHODS: A cross-sectional
      study of patients taking ART was conducted in two rural and two urban
      sub-districts, involving 13 accredited facilities and 1266 participants selected 
      through systematic random sampling. Structured questionnaires were used in
      interviews, and participant's clinic records were reviewed. Data collected
      included household assets, healthcare access dimensions (availability,
      affordability and acceptability), healthcare utilization and pluralism, and
      laboratory-based outcomes. Multiple logistic regression models were fitted to
      identify predictors of healthcare pluralism and associations with treatment
      outcomes. Prior ethical approval and informed consent were obtained. RESULTS:
      Nineteen percent of respondents reported use of additional healthcare providers
      over and above their regular ART visits in the prior month. A further 15% of
      respondents reported additional expenditure on self-care (e.g. special foods).
      Access to health insurance (Adjusted odds ratio [aOR] 6.15) and disability grants
      (aOR 1.35) increased plural healthcare use. However, plural healthcare users were
      more likely to borrow money to finance healthcare (aOR 2.68), and incur
      catastrophic levels of healthcare expenditure (27%) than non-plural users (7%).
      Quality of care factors, such as perceived disrespect by staff (aOR 2.07) and
      lack of privacy (aOR 1.50) increased plural healthcare utilization. Plural
      healthcare utilization was associated with rural residence (aOR 1.97). Healthcare
      pluralism was not associated with missed visits or biological outcomes.
      CONCLUSION: Increased plural healthcare utilization, inequitably distributed
      between rural and urban areas, is largely a function of higher socioeconomic
      status, better ability to finance healthcare and factors related to poor quality 
      of care in ART clinics. Plural healthcare utilization may be an indication of
      patients' dissatisfaction with perceived quality of ART care provided. Healthcare
      expenditure of a catastrophic nature remained a persistent complication. Plural
      healthcare utilization did not appear to influence clinical outcomes. However,
      there were potential negative impacts on the livelihoods of patients and their
      households.
FAU - Moshabela, Mosa
AU  - Moshabela M
AD  - Rural AIDS and Development Action Research, School of Public Health, University
      of Witwatersrand, Acornhoek, Mpumalanga Province, Johannesburg, South Africa.
      mosa@agincourt.co.za
FAU - Schneider, Helen
AU  - Schneider H
FAU - Silal, Sheetal P
AU  - Silal SP
FAU - Cleary, Susan M
AU  - Cleary SM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120702
PL  - England
TA  - BMC Health Serv Res
JT  - BMC health services research
JID - 101088677
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Africa South of the Sahara
MH  - Anti-HIV Agents/*therapeutic use
MH  - Cost of Illness
MH  - Cross-Sectional Studies
MH  - Female
MH  - HIV Infections/*drug therapy
MH  - *Health Services Accessibility/economics
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Patient Acceptance of Health Care/psychology/statistics & numerical data
MH  - Physician-Patient Relations
MH  - Program Evaluation
MH  - Rural Health Services/economics/*statistics & numerical data/trends
MH  - Self Care/methods
MH  - Social Class
MH  - Social Support
MH  - Surveys and Questionnaires
MH  - Urban Health Services/economics/*statistics & numerical data/trends
PMC - PMC3465179
EDAT- 2012/07/04 06:00
MHDA- 2013/01/08 06:00
CRDT- 2012/07/04 06:00
PHST- 2011/01/12 00:00 [received]
PHST- 2012/06/12 00:00 [accepted]
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2013/01/08 06:00 [medline]
AID - 1472-6963-12-182 [pii]
AID - 10.1186/1472-6963-12-182 [doi]
PST - epublish
SO  - BMC Health Serv Res. 2012 Jul 2;12:182. doi: 10.1186/1472-6963-12-182.


PMID- 22747883
OWN - NLM
STAT- MEDLINE
DCOM- 20121119
LR  - 20220331
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 13
DP  - 2012 Jul 2
TI  - Seeking consent to genetic and genomic research in a rural Ghanaian setting: a
      qualitative study of the MalariaGEN experience.
PG  - 15
LID - 10.1186/1472-6939-13-15 [doi]
AB  - BACKGROUND: Seeking consent for genetic and genomic research can be challenging, 
      particularly in populations with low literacy levels, and in emergency
      situations. All of these factors were relevant to the MalariaGEN study of genetic
      factors influencing immune responses to malaria in northern rural Ghana. This
      study sought to identify issues arising in practice during the enrollment of
      paediatric cases with severe malaria and matched healthy controls into the
      MalariaGEN study. METHODS: The study used a rapid assessment incorporating
      multiple qualitative methods including in depth interviews, focus group
      discussions and observations of consent processes. Differences between verbal
      information provided during community engagement processes, and consent processes
      during the enrollment of cases and controls were identified, as well as the
      factors influencing the tailoring of such information. RESULTS: MalariaGEN
      participants and field staff seeking consent were generally satisfied with their 
      understanding of the project and were familiar with aspects of the study relating
      to malaria. Some genetic aspects of the study were also well understood.
      Participants and staff seeking consent were less aware of the methodologies
      employed during genomic research and their implications, such as the breadth of
      data generated and the potential for future secondary research.Moreover, trust in
      and previous experience with the Navrongo Health Research Centre which was
      conducting the research influenced beliefs about the benefits of participating in
      the MalariaGEN study and subsequent decision-making about research participation.
      CONCLUSIONS: It is important to recognise that some aspects of complex genomic
      research may be of less interest to and less well understood by research
      participants and that such gaps in understanding may not be entirely addressed by
      best practice in the design and conduct of consent processes. In such
      circumstances consideration needs to be given to additional protections for
      participants that may need to be implemented in such research, and how best to
      provide such protections.Capacity building for research ethics committees with
      limited familiarity with genetic and genomic research, and appropriate engagement
      with communities to elicit opinions of the ethical issues arising and
      acceptability of downstream uses of genome wide association data are likely to be
      important.
FAU - Tindana, Paulina
AU  - Tindana P
AD  - The Ethox Centre, Department of Public Health, University of Oxford, Old Road
      Campus, Headington, Oxford, OX3 7LF, United Kingdom.
FAU - Bull, Susan
AU  - Bull S
FAU - Amenga-Etego, Lucas
AU  - Amenga-Etego L
FAU - de Vries, Jantina
AU  - de Vries J
FAU - Aborigo, Raymond
AU  - Aborigo R
FAU - Koram, Kwadwo
AU  - Koram K
FAU - Kwiatkowski, Dominic
AU  - Kwiatkowski D
FAU - Parker, Michael
AU  - Parker M
LA  - eng
GR  - 096527/WT_/Wellcome Trust/United Kingdom
GR  - 075491/Z/04/WT_/Wellcome Trust/United Kingdom
GR  - G0600718/MRC_/Medical Research Council/United Kingdom
GR  - 77383/Z/05/Z/WT_/Wellcome Trust/United Kingdom
GR  - WT077383/Z/05/Z/WT_/Wellcome Trust/United Kingdom
GR  - 090532/WT_/Wellcome Trust/United Kingdom
GR  - 077012/Z/05/Z/WT_/Wellcome Trust/United Kingdom
GR  - 090532/Z/09/Z/WT_/Wellcome Trust/United Kingdom
GR  - 098051/WT_/Wellcome Trust/United Kingdom
GR  - G19/9/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120702
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Case-Control Studies
MH  - Confounding Factors, Epidemiologic
MH  - Focus Groups
MH  - Genetic Research/*ethics
MH  - Genome-Wide Association Study
MH  - Ghana
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Malaria/*genetics/immunology
MH  - Metagenomics
MH  - Narration
MH  - Qualitative Research
MH  - *Rural Population
PMC - PMC3441464
EDAT- 2012/07/04 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/04 06:00
PHST- 2011/06/09 00:00 [received]
PHST- 2012/05/08 00:00 [accepted]
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 1472-6939-13-15 [pii]
AID - 10.1186/1472-6939-13-15 [doi]
PST - epublish
SO  - BMC Med Ethics. 2012 Jul 2;13:15. doi: 10.1186/1472-6939-13-15.


PMID- 22747798
OWN - NLM
STAT- MEDLINE
DCOM- 20121126
LR  - 20220321
IS  - 2046-4924 (Electronic)
IS  - 1366-5278 (Linking)
VI  - 16
IP  - 30
DP  - 2012 Jul
TI  - The measurement of patients' expectations for health care: a review and
      psychometric testing of a measure of patients' expectations.
PG  - i-xii, 1-509
LID - 10.3310/hta16300 [doi]
AB  - BACKGROUND: There is recognition of the importance of measuring patients'
      experiences, expectations and satisfaction. OBJECTIVES: To assess the literature 
      on the concept and measurement of patients' expectations for health care, and to 
      develop and test a measure of patients' expectations, using adult patients in
      community, general practice and hospital outpatient departments in Greater
      London, Norwich and Essex, UK. DATA SOURCES: Major electronic databases including
      the British Nursing Index, EMBASE, MEDLINE, PsycINFO and the Applied Social
      Sciences Index and Abstracts were searched between 2000 and 2009. REVIEW METHODS:
      Narrative review, semi-structured exploratory study and surveys of GP patients
      and hospital outpatients immediately before and after their surgery/clinic visit 
      to measure their pre-visit expectations for their health care and their
      post-visit experiences (expectations met and satisfaction with visit) (site
      specific). RESULTS: A total of 20,439 titles and 266 abstracts were identified,
      of which 211 were included in the review. Most research designs were weak, with
      small or selected samples, and a theoretical frame of reference was rarely
      stated. The origin of questions about expectations was often absent, questions
      were frequently untested and those with reported reliability or validity data had
      generally mixed results. In the survey data the expectations measures met
      acceptability criteria for reliability; all exceeded the threshold of alpha =
      0.70, in each mode of administration and sample type. Items and subscales also
      correlated at least moderately with those variables that they were expected to be
      associated with, supporting their validity. The item means within subscales were 
      generally similar between samples and all-item-total correlations exceeded the
      acceptability threshold. Descriptive findings revealed that most patients ideally
      expected cleanliness, information about where to go, convenient and punctual
      appointments and helpful reception staff, the doctor to be knowledgeable, clear
      and easy to understand, to be involved in treatment decisions and to experience a
      reduction in symptoms/problems. Expectations least likely to be met included
      being seen on time and choice of hospital/doctor (items requested by the ethics
      committee). Other items that had low met expectations included helpfulness of
      reception staff, doctor being respectful and treating with dignity (hospital
      sample), doctor knowledgeable (hospital), being given reassurance, receiving
      advice about health/condition, information about cause and management of
      condition and information about benefits/side effects of treatment, being given
      an opportunity to discuss problems, and the three items on outcome expectancies. 
      Previous consultations/experiences of health services and health-care
      staff/professionals most commonly influenced expectations. Overall, pre-visit
      realistic expectations were lower than patients' ideals or hopes. Most post-visit
      experiences indicated some unmet expectations (e.g. cause and management of
      health/condition, benefits/side effects of treatments) and some expectations that
      were exceeded. Generally, GP patients reported higher pre-visit expectations and 
      post-visit met expectations. Correlations between subscale domains were strongest
      between the structure and process of health care, doctor-patient communication
      style and doctor's approach to giving information, all common indicators of the
      quality of health care, supporting the validity of the measures. The post-visit
      experiences subscale significantly predicted single-item summary ratings of
      overall met expectations and satisfaction. GP rather than hospital patients were 
      also independently predictive of expectations met. Other predictors were having
      no/little anxiety/depression, older age (satisfaction) and fewer effects of
      health on quality of life (met expectations). LIMITATIONS: The surveys in clinics
      were based on convenience, not random sampling methods. CONCLUSIONS: These
      findings have implications for establishing the quality of health services and
      informing their improvement. Awareness of the patient's met and unmet
      expectations should enable staff to understand the patient's perspective and
      improve communication. This study examined the perspective of the patient only;
      it is not possible to examine the extent to which any expectations might have
      been unrealistically too high or too low. This is a challenge for future
      research. FUNDING: The National Institute for Health Research Health Technology
      Assessment programme and the National Co-ordinating Centre for Research
      Methodology (NCCRM).
FAU - Bowling, A
AU  - Bowling A
AD  - Faculty of Health Sciences, University of Southampton, Southampton, UK.
FAU - Rowe, G
AU  - Rowe G
FAU - Lambert, N
AU  - Lambert N
FAU - Waddington, M
AU  - Waddington M
FAU - Mahtani, K R
AU  - Mahtani KR
FAU - Kenten, C
AU  - Kenten C
FAU - Howe, A
AU  - Howe A
FAU - Francis, S A
AU  - Francis SA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Health Technol Assess
JT  - Health technology assessment (Winchester, England)
JID - 9706284
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Delivery of Health Care
MH  - England
MH  - Female
MH  - Health Care Surveys/*standards
MH  - Hospitalization
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Patient Satisfaction/statistics & numerical data
MH  - Psychometrics
MH  - Reproducibility of Results
EDAT- 2012/07/04 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/07/04 06:00
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.3310/hta16300 [doi]
PST - ppublish
SO  - Health Technol Assess. 2012 Jul;16(30):i-xii, 1-509. doi: 10.3310/hta16300.


PMID- 22747673
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121019
LR  - 20211021
IS  - 2110-5820 (Electronic)
IS  - 2110-5820 (Linking)
VI  - 2
IP  - 1
DP  - 2012 Jul 2
TI  - Contribution of the ethics committee of the French Intensive Care Society to
      describing a scenario for implementing organ donation after Maastricht type III
      cardiocirculatory death in France.
PG  - 23
LID - 10.1186/2110-5820-2-23 [doi]
AB  - French law allows organ donation after death due to cardiocirculatory arrest. In 
      the Maastricht classification, type III non-heart-beating donors are those who
      experience cardiocirculatory arrest after the withdrawal of life-sustaining
      treatments. French authorities in charge of regulating organ donation (Agence de 
      la Biomedecine, ABM) are considering organ collection from Maastricht type III
      donors. We describe a scenario for Maastricht type III organ donation that fully 
      complies with the ethical norms governing care to dying patients. That organ
      donation may occur after death should have no impact on the care given to the
      patient and family. The dead-donor rule must be followed scrupulously: the organ 
      retrieval procedure must neither cause nor hasten death. The decision to withdraw
      life-sustaining treatments, withdrawal modalities, and care provided to the
      patient and family must adhere strictly to the requirements set forth in
      patient-rights legislation (the 2005 Leonetti law in France) and should not be
      influenced in any way by the possibility of organ donation. A major ethical issue
      regarding the family is how best to transition from discussing
      treatment-withdrawal decisions to discussing possible organ retrieval for
      donation should the patient die rapidly after treatment withdrawal. Close
      cooperation between the healthcare team and the organ retrieval team is crucial
      to minimize the distress of family members during this transition. Modalities for
      implementing Maastricht type III organ donation are discussed here, including the
      best location for withdrawing life-sustaining treatments (operating room or
      intensive care unit).
FAU - Graftieaux, Jean-Pierre
AU  - Graftieaux JP
AD  - Service de Reanimation Medico-Chirurgicale, CHU Louis Mourier, 92700, Colombes,
      France. didier.dreyfuss@lmr.aphp.fr.
FAU - Bollaert, Pierre-Edouard
AU  - Bollaert PE
FAU - Haddad, Lise
AU  - Haddad L
FAU - Kentish-Barnes, Nancy
AU  - Kentish-Barnes N
FAU - Nitenberg, Gerard
AU  - Nitenberg G
FAU - Robert, Rene
AU  - Robert R
FAU - Villers, Daniel
AU  - Villers D
FAU - Dreyfuss, Didier
AU  - Dreyfuss D
LA  - eng
PT  - Journal Article
DEP - 20120702
PL  - Germany
TA  - Ann Intensive Care
JT  - Annals of intensive care
JID - 101562873
PMC - PMC3475084
EDAT- 2012/07/04 06:00
MHDA- 2012/07/04 06:01
CRDT- 2012/07/04 06:00
PHST- 2012/04/10 00:00 [received]
PHST- 2012/07/02 00:00 [accepted]
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2012/07/04 06:01 [medline]
AID - 2110-5820-2-23 [pii]
AID - 10.1186/2110-5820-2-23 [doi]
PST - epublish
SO  - Ann Intensive Care. 2012 Jul 2;2(1):23. doi: 10.1186/2110-5820-2-23.


PMID- 22747192
OWN - NLM
STAT- MEDLINE
DCOM- 20121226
LR  - 20140731
IS  - 1557-7740 (Electronic)
IS  - 1557-7740 (Linking)
VI  - 15
IP  - 8
DP  - 2012 Aug
TI  - Framework for continuous palliative sedation therapy in Canada.
PG  - 870-9
LID - 10.1089/jpm.2011.0498 [doi]
AB  - BACKGROUND: Canada does not have a standardized ethical and practice framework
      for continuous palliative sedation therapy (CPST). Although a number of
      institutional and regional guidelines exist, Canadian practice varies. Given the 
      lack of international and national consensus on CPST, the Canadian Society for
      Palliative Care Physicians (CSPCP) formed a special task force to develop a
      consensus-based framework for CPST. OBJECTIVE: Through a preliminary review of
      sedation practices nationally and internationally, it was determined that
      although considerable consensus was emerging on this topic, there remained both
      areas of contention and a lack of credible scientific evidence to support a
      definitive clinical practice guideline. This led to the creation of a framework
      to help guide policy, practice, and research. METHODS: This framework was
      developed through the following steps: 1) literature review; 2) identification of
      issues; 3) preparation of a draft framework; 4) expert consultation and revision;
      5) presentation at conferences and further revision; and 6) further revision and 
      national consensus building. RESULTS: A thorough literature review, including
      gray literature, of sedation therapy at the end of life was conducted from which 
      an initial framework was drafted. This document was reviewed by 30
      multidisciplinary experts in Canada and internationally, revised several times,
      and then submitted to CSPCP members for review. Consensus was high on most parts 
      of the framework. CONCLUSION: The framework for CPST will provide a basis for the
      development of safe, effective, and ethical use of CPST for patients in
      palliative care and at the end of life.
FAU - Dean, Mervyn M
AU  - Dean MM
AD  - Palliative Care, Western Memorial Regional Hospital, Corner Brook, Newfoundland
      and Labrador, Canada. merv.d@nf.sympatico.ca
FAU - Cellarius, Victor
AU  - Cellarius V
FAU - Henry, Blair
AU  - Henry B
FAU - Oneschuk, Doreen
AU  - Oneschuk D
FAU - Librach Canadian Society Of Palliative Care Physicians Taskforce, S Lawrence
AU  - Librach Canadian Society Of Palliative Care Physicians Taskforce SL
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120702
PL  - United States
TA  - J Palliat Med
JT  - Journal of palliative medicine
JID - 9808462
RN  - 0 (Hypnotics and Sedatives)
SB  - IM
MH  - Canada
MH  - Consensus
MH  - Deep Sedation/methods/*standards
MH  - *Health Policy
MH  - Humans
MH  - Hypnotics and Sedatives/*administration & dosage/standards
MH  - Pain, Intractable/*drug therapy
MH  - Palliative Care/ethics/methods/*standards
MH  - Practice Guidelines as Topic
EDAT- 2012/07/04 06:00
MHDA- 2012/12/27 06:00
CRDT- 2012/07/04 06:00
PHST- 2012/07/04 06:00 [entrez]
PHST- 2012/07/04 06:00 [pubmed]
PHST- 2012/12/27 06:00 [medline]
AID - 10.1089/jpm.2011.0498 [doi]
PST - ppublish
SO  - J Palliat Med. 2012 Aug;15(8):870-9. doi: 10.1089/jpm.2011.0498. Epub 2012 Jul 2.


PMID- 26105403
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150625
LR  - 20150624
IS  - 2210-7789 (Print)
IS  - 2210-7789 (Linking)
VI  - 2
IP  - 3
DP  - 2012 Jul
TI  - PP081. Study group obstetrics - A platform for efficient collaboration and
      networking in obstetrical science.
PG  - 284
LID - 10.1016/j.preghy.2012.04.192 [doi]
LID - S2210-7789(12)00221-8 [pii]
AB  - INTRODUCTION: Modern medical science has to meet a series of challenges including
      the integration of new technologies and strategies to daily scientific routine.
      Biobanking is defined as 'a collection of biological material and the associated 
      data and information stored in an organized system for a population or a large
      subset of a population' and plays a key role in these efforts. OBJECTIVES: The
      study group obstetrics aims to establish a platform for efficient collaboration
      and networking in obstetrical science. METHODS: Based on existing resources,
      technologies and expertise, autonomous data and sample collection in local
      biobanks shall be processed with uniformed SOPs to guarantee quality and
      compatibility. RESULTS: The study group obstetrics has created harmonized
      standards for sample and data management in biobanks as well as ethical and legal
      frameworks. Internet - based data management with uniform documentation sheets
      guarantee high data quality. Material and data are administrated autonomously and
      can be combined in the context of specific co-operations. CONCLUSION: Due to the 
      outstanding dynamics over a limited period, the human pregnancy is an attractive 
      field for biobanking and clinical case/control cohorts including disease focused 
      cohorts. Harmonized standards and linkage in a network allow efficient scientific
      co-operations. Everyone interested is invited to join the study group obstetrics 
      as an equitable member.
CI  - Copyright (c) 2012. Published by Elsevier B.V.
FAU - Kuessel, L
AU  - Kuessel L
AD  - Obstetrics & fetal medicine, Medical University of Vienna, Vienna, Austria.
FAU - Wild, J
AU  - Wild J
AD  - Obstetrics & fetal medicine, Medical University of Vienna, Vienna, Austria.
FAU - Zeisler, H
AU  - Zeisler H
AD  - Obstetrics & fetal medicine, Medical University of Vienna, Vienna, Austria.
LA  - eng
PT  - Journal Article
DEP - 20120613
PL  - Netherlands
TA  - Pregnancy Hypertens
JT  - Pregnancy hypertension
JID - 101552483
EDAT- 2012/07/01 00:00
MHDA- 2012/07/01 00:01
CRDT- 2015/06/25 06:00
PHST- 2015/06/25 06:00 [entrez]
PHST- 2012/07/01 00:00 [pubmed]
PHST- 2012/07/01 00:01 [medline]
AID - S2210-7789(12)00221-8 [pii]
AID - 10.1016/j.preghy.2012.04.192 [doi]
PST - ppublish
SO  - Pregnancy Hypertens. 2012 Jul;2(3):284. doi: 10.1016/j.preghy.2012.04.192. Epub
      2012 Jun 13.


PMID- 26105399
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150625
LR  - 20150624
IS  - 2210-7789 (Print)
IS  - 2210-7789 (Linking)
VI  - 2
IP  - 3
DP  - 2012 Jul
TI  - PP077. Effect of maternal antioxidant concentrations on expressions of
      angiogenesis-related genes in the villous trophoblasts from early pregnancy.
PG  - 282
LID - 10.1016/j.preghy.2012.04.188 [doi]
LID - S2210-7789(12)00217-6 [pii]
AB  - INTRODUCTION: The pathogenesis of preeclampsia is associated with oxidative
      stress of villous trophoblasts in early pregnancy. We have reported that
      antioxidant supplementations from 12weeks of gestation could prevent mild
      preeclampsia in pregnant women with oxidative stress. OBJECTIVES: To prove the
      effect of maternal antioxidant concentrations on expressions of
      angiogenesis-related genes in the villous trophoblasts from early pregnancy.
      METHODS: Villous tissue and blood samples were obtained from pregnant women who
      had artificial abortions between 6 and 11weeks of gestation. RNA was extracted
      from villous tissue, and gene expression levels of fms-like tyrosine kinase-1
      (FLT-1), endoglin (ENG), and placental growth factor (PGF) in villous tissue were
      measured by reverse transcription polymerase chain reaction. Serum vitamin C and 
      E concentrations were measured by enzyme-linked immunosorbent assay. This study
      was approved by the Ethics Committee of Showa University Hospital. RESULTS:
      Negative correlations between maternal serum vitamin C levels and gene
      expressions of ENG (r=-0.856, p=0.007) and FLT-1 (r=-0.898, p=0.002) in the
      villous trophoblasts were observed. There was no correlation of maternal serum
      vitamin E concentration with any other gene expression in the villous
      trophoblasts. CONCLUSION: It is suggested that maternal oxidative stress may
      increase the gene expressions of anti-angiogenic factors in villous trophoblasts 
      of early gestation, which may lead to the pathogenesis of preeclampsia.
CI  - Copyright (c) 2012. Published by Elsevier B.V.
FAU - Koide, K
AU  - Koide K
AD  - Obstetrics and Gynecology, Showa University School of Medicine, Tokyo, Japan.
FAU - Sekizawa, A
AU  - Sekizawa A
AD  - Obstetrics and Gynecology, Showa University School of Medicine, Tokyo, Japan.
FAU - Shinjo, A
AU  - Shinjo A
AD  - Obstetrics and Gynecology, Showa University School of Medicine, Tokyo, Japan.
FAU - Matsuoka, R
AU  - Matsuoka R
AD  - Obstetrics and Gynecology, Showa University School of Medicine, Tokyo, Japan.
FAU - Ichizuka, K
AU  - Ichizuka K
AD  - Obstetrics and Gynecology, Showa University School of Medicine, Tokyo, Japan.
FAU - Hori, K
AU  - Hori K
AD  - Obstetrics and Gynecology, Showa University School of Medicine, Tokyo, Japan.
FAU - Oishi, S
AU  - Oishi S
AD  - Obstetrics and Gynecology, Showa University School of Medicine, Tokyo, Japan.
FAU - Okai, T
AU  - Okai T
AD  - Obstetrics and Gynecology, Showa University School of Medicine, Tokyo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20120613
PL  - Netherlands
TA  - Pregnancy Hypertens
JT  - Pregnancy hypertension
JID - 101552483
EDAT- 2012/07/01 00:00
MHDA- 2012/07/01 00:01
CRDT- 2015/06/25 06:00
PHST- 2015/06/25 06:00 [entrez]
PHST- 2012/07/01 00:00 [pubmed]
PHST- 2012/07/01 00:01 [medline]
AID - S2210-7789(12)00217-6 [pii]
AID - 10.1016/j.preghy.2012.04.188 [doi]
PST - ppublish
SO  - Pregnancy Hypertens. 2012 Jul;2(3):282. doi: 10.1016/j.preghy.2012.04.188. Epub
      2012 Jun 13.


PMID- 26105373
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150625
LR  - 20150624
IS  - 2210-7789 (Print)
IS  - 2210-7789 (Linking)
VI  - 2
IP  - 3
DP  - 2012 Jul
TI  - PP049. Could the supplementation of L-arginine plus folic acid T improve reduced 
      endothelial function seen in preeclampsia?
PG  - 268
LID - 10.1016/j.preghy.2012.04.160 [doi]
LID - S2210-7789(12)00189-4 [pii]
AB  - INTRODUCTION: Preeclampsia is characterized as an increase in vascular tone due
      to the disorder of endothelial cell function. It was found that action of nitric 
      oxide (NO) derived from endothelial cell might be decreasing in preeclamptic
      women. OBJECTIVES: In the present study, we investigated whether or not the
      supplementation of L-arginine (LARG, NO synthase substrate) and folic acid (FA)
      might improve the reduced action of NO seen in preeclampsia. METHODS: Change in
      brachial artery diameter by hyperemia (%FMD) was measured to evaluate the
      endothelial function using ultrasound. Twelve of 25 normal pregnant women seen
      with reduced %FMD (<110) at less than 16weeks of gestation were given the
      supplementation of FA 0.8mg+LARG1g/day throughout pregnancy. The concentrations
      of FA+LARG in erythrocyte, and cGMP (a second messenger of NO) in serum were
      measured. The informed consent was obtained from each patient. This investigation
      was approved by the Ethics Committee of Nagoya City East and West Medical Center.
      RESULTS: Reduced % FMD was seen in 25 pregnant women. One of 12 pregnant women in
      the supplementation group developed mild, late onset preeclampsia, while 8 of 13 
      pregnant women in no supplement group developed onset preeclampsia (4 cases were 
      severe). Following the supplementation, %FMD had been increasing as well as the
      concentrations of FA and LARG in erythrocyte, while the concentration of cGMP in 
      serum had not changed. CONCLUSION: The supplementation of FA+LARG might prevent
      preeclampsia due to improvement of the reduced endothelial function in high risk 
      pregnant women of preeclampsia.
CI  - Copyright (c) 2012. Published by Elsevier B.V.
FAU - Suzuki, Y
AU  - Suzuki Y
AD  - Obstetrics and Gynecology, Nagoya City West Medical Center, Japan.
FAU - Yamamoto, T
AU  - Yamamoto T
AD  - Pharmacology, Nagoya City University, Nagoya, Japan.
FAU - Matsuura, A
AU  - Matsuura A
AD  - Obstetrics and Gynecology, Nagoya City West Medical Center, Japan.
LA  - eng
PT  - Journal Article
DEP - 20120613
PL  - Netherlands
TA  - Pregnancy Hypertens
JT  - Pregnancy hypertension
JID - 101552483
EDAT- 2012/07/01 00:00
MHDA- 2012/07/01 00:01
CRDT- 2015/06/25 06:00
PHST- 2015/06/25 06:00 [entrez]
PHST- 2012/07/01 00:00 [pubmed]
PHST- 2012/07/01 00:01 [medline]
AID - S2210-7789(12)00189-4 [pii]
AID - 10.1016/j.preghy.2012.04.160 [doi]
PST - ppublish
SO  - Pregnancy Hypertens. 2012 Jul;2(3):268. doi: 10.1016/j.preghy.2012.04.160. Epub
      2012 Jun 13.


PMID- 26105364
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150625
LR  - 20150624
IS  - 2210-7789 (Print)
IS  - 2210-7789 (Linking)
VI  - 2
IP  - 3
DP  - 2012 Jul
TI  - PP040. Expression of RANTES (CCL5) in maternal plasma, fetal plasma and placenta 
      in pre-eclampsia and normotensive controls.
PG  - 263
LID - 10.1016/j.preghy.2012.04.151 [doi]
LID - S2210-7789(12)00180-8 [pii]
AB  - INTRODUCTION: Studies have shown pre-eclampsia (PE) as an exacerbation of
      gestational inflammatory process. RANTES (Regulated upon Activation, Normal
      T-cell Expressed, and Secreted)/CCL5 is a chemokine, which is involved in chronic
      inflammation by the recruitment of inflammatory cells. It is secreted by many
      cell types such as endothelial cells, smooth muscle cells, macrophages, platelets
      and activated T-cells. Thus we hypothesized that RANTES expression is altered in 
      PE and may be different in gestational tissues (maternal plasma, fetal plasma and
      placenta). OBJECTIVES: The purpose of the study is to analyze the expression of
      RANTES (CCL5) in three different tissues: maternal plasma, fetal plasma and
      placenta, in PE and normotensive controls (NC). METHODS: PE was diagnosed by the 
      National High Blood Pressure Education Program Working Group Report on High Blood
      Pressure in Pregnancy guidelines. The patients were assisted in the Sao Lucas
      Hospital from PUCRS, Porto Alegre, Brazil. Following ethical approval and
      informed written consent, maternal and umbilical plasma and placental biopsies
      were taken from 33 PE and 35 NC. Samples were centrifuged immediately after blood
      collection and plasma was stored at -80 degrees C until assay. Placental Biopsies
      were taken midway between the cord and periphery, from the central region of
      cotyledons and were stored as well. RANTES expression was made by the ELISA test,
      in duplicates. They were also analyzed in each group: maternal age, maternal
      parity, gestational age on delivery, glucose, body mass index, proteinuria
      creatinuria ratio, systolic blood pressure (SBP), diastolic blood pressure (DBP),
      delivery method, birth weight, placental weight and Apgar index in 1st and 5th
      minute. RESULTS: Maternal age at the time of blood collection was not
      significantly different between the two groups. The women with preeclampsia
      delivered earlier and had smaller babies compared with the controls. Significant 
      associations between groups (p<0.001) were seen in SBP, DBP, birth weight and
      delivery method. RANTES was increased in maternal plasma and placenta in patients
      with PE and decreased in fetus plasma in the same group (p<0.001). CONCLUSION: In
      this study, we have shown that RANTES expression in maternal plasma and placenta 
      tissues, in women with established pre-eclampsia, is higher than in
      gestation-matched women with a healthy pregnancy. It confirms the hypotheses that
      physiology of PE is associated with an increase of normal gestational
      inflammatory process. However in fetus tissue, the inflammatory chemokine is
      decreased in PE women. FUNDING: CAPES Foundation, Ministry of Education of
      Brazil, Brasilia - DF 70040-020, Brazil.
CI  - Copyright (c) 2010. Published by Elsevier B.V.
FAU - Hentschke, M R
AU  - Hentschke MR
AD  - Nephrology, School of Medicine, Pontificia Universidade Catolica do Rio Grande do
      Sul, Porto Alegre, Brazil.
FAU - Krauspenhar, B
AU  - Krauspenhar B
AD  - Nephrology, School of Medicine, Pontificia Universidade Catolica do Rio Grande do
      Sul, Porto Alegre, Brazil.
FAU - Guwzinski, A
AU  - Guwzinski A
AD  - Nephrology, School of Medicine, Pontificia Universidade Catolica do Rio Grande do
      Sul, Porto Alegre, Brazil.
FAU - Caruso, F B
AU  - Caruso FB
AD  - Nephrology, School of Medicine, Pontificia Universidade Catolica do Rio Grande do
      Sul, Porto Alegre, Brazil.
FAU - Silveira, I D
AU  - Silveira ID
AD  - Nephrology, School of Medicine, Pontificia Universidade Catolica do Rio Grande do
      Sul, Porto Alegre, Brazil.
FAU - Antonello, I C
AU  - Antonello IC
AD  - Nephrology, School of Medicine, Pontificia Universidade Catolica do Rio Grande do
      Sul, Porto Alegre, Brazil.
FAU - Gadonski, G
AU  - Gadonski G
AD  - Nephrology, School of Medicine, Pontificia Universidade Catolica do Rio Grande do
      Sul, Porto Alegre, Brazil.
FAU - Poli-de-Figueiredo, C E
AU  - Poli-de-Figueiredo CE
AD  - Nephrology, School of Medicine, Pontificia Universidade Catolica do Rio Grande do
      Sul, Porto Alegre, Brazil.
FAU - da Costa, B E Pinheiro
AU  - da Costa BE
AD  - Nephrology, School of Medicine, Pontificia Universidade Catolica do Rio Grande do
      Sul, Porto Alegre, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20120613
PL  - Netherlands
TA  - Pregnancy Hypertens
JT  - Pregnancy hypertension
JID - 101552483
EDAT- 2012/07/01 00:00
MHDA- 2012/07/01 00:01
CRDT- 2015/06/25 06:00
PHST- 2015/06/25 06:00 [entrez]
PHST- 2012/07/01 00:00 [pubmed]
PHST- 2012/07/01 00:01 [medline]
AID - S2210-7789(12)00180-8 [pii]
AID - 10.1016/j.preghy.2012.04.151 [doi]
PST - ppublish
SO  - Pregnancy Hypertens. 2012 Jul;2(3):263. doi: 10.1016/j.preghy.2012.04.151. Epub
      2012 Jun 13.


PMID- 26105279
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150625
LR  - 20150624
IS  - 2210-7789 (Print)
IS  - 2210-7789 (Linking)
VI  - 2
IP  - 3
DP  - 2012 Jul
TI  - OS065. Placental growth factor as a diagnostic and prognostic test forplacental
      complications of pregnancy.
PG  - 212
LID - 10.1016/j.preghy.2012.04.066 [doi]
LID - S2210-7789(12)00095-5 [pii]
AB  - INTRODUCTION: Placental growth factor (PlGF) levels in maternal circulation are
      altered in pre-eclampsia and intrauterine growth restriction (IUGR) (Benton et
      al.) and may have utility in identifying cases associated with placental
      dysfunction and stratifying pregnancy survival. OBJECTIVES: We sought to
      determine if a positive PlGF test measured on the Triage PlGF rapid assay (Alere,
      San Diego) agrees with the clinical diagnosis and predicts preterm delivery.
      METHODS: EDTA-blood was collected from women admitted to the AMC Obstetrics
      Department after 20 weeks of gestation with informed consent and according to the
      protocol approved by the AMC Medical Ethical Board (10/127). Plasma free PlGF
      levels from women diagnosed with early-onset pre-eclampsia (n=28), normotensive
      IUGR (N=6) and pregnancy complications excluding pre-eclampsia and IUGR (n=18)
      were quantified using the Triage PlGF immunoassay. Samples were collected before 
      GA 34+6 and analyzed in batch assay. Results were interpreted against
      GA-dependent cutoffs set at the 5th centile for gestational age in normal
      pregnancy (Knudsen et al). PlGF levels below the cutoffs were assigned "positive"
      according to the product insert. The proportion of subjects with a positive PlGF 
      test result was calculated for each group, together with the proportion of
      subjects requiring preterm delivery. RESULTS: Twenty-eight women developed
      early-onset pre-eclampsia and, of these, 27/28 (96.4%) had a positive PlGF test. 
      The woman with negative PlGF test presented to clinic at GA 34+3 with
      hypertension and suspected pre-eclampsia, but delivered at GA 39+4. Six women
      developed normotensive IUGR, of which 4 had a positive PlGF test, and in each the
      PlGF level was below the limit of detection of the test. The 2 women with a
      negative PlGF test had twin pregnancies. Eighteen women developed pregnancy
      complications excluding pre-eclampsia and IUGR. Six had at least one serial
      sample with a positive PlGF test. Of these, one woman had partial placental
      abruption, 3 had PPROM, one had spontaneous labour at GA 33+3, and one had
      bleeding after elective embryo reduction and neonatal death during delivery at
      23+3. The proportion of women with a positive PlGF test, where the date of
      delivery is known, requiring preterm delivery was 34/37 (91.9%). CONCLUSION:
      These preliminary data suggest that a positive PlGF test by Triage may identify
      placentally-mediated pregnancy complications and that a very low level of PlGF
      identifies women at increased risk for preterm delivery.
CI  - Copyright (c) 2012. Published by Elsevier B.V.
FAU - Ris-Stalpers, C
AU  - Ris-Stalpers C
AD  - Women's and Children's Clinic, Academic Medical Centre, Amsterdam, Netherlands;
      Reproductive Biology Laboratory, Academic Medical Centre, Amsterdam, Netherlands.
FAU - Lahsinoui, H Hassani
AU  - Lahsinoui HH
AD  - Women's and Children's Clinic, Academic Medical Centre, Amsterdam, Netherlands;
      Reproductive Biology Laboratory, Academic Medical Centre, Amsterdam, Netherlands.
FAU - Boussata, S
AU  - Boussata S
AD  - Reproductive Biology Laboratory, Academic Medical Centre, Amsterdam, Netherlands.
FAU - van der Post, J Am
AU  - van der Post JA
AD  - Women's and Children's Clinic, Academic Medical Centre, Amsterdam, Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20120613
PL  - Netherlands
TA  - Pregnancy Hypertens
JT  - Pregnancy hypertension
JID - 101552483
EDAT- 2012/07/01 00:00
MHDA- 2012/07/01 00:01
CRDT- 2015/06/25 06:00
PHST- 2015/06/25 06:00 [entrez]
PHST- 2012/07/01 00:00 [pubmed]
PHST- 2012/07/01 00:01 [medline]
AID - S2210-7789(12)00095-5 [pii]
AID - 10.1016/j.preghy.2012.04.066 [doi]
PST - ppublish
SO  - Pregnancy Hypertens. 2012 Jul;2(3):212. doi: 10.1016/j.preghy.2012.04.066. Epub
      2012 Jun 13.


PMID- 25885612
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150418
LR  - 20200929
IS  - 0259-1162 (Print)
IS  - 2229-7685 (Linking)
VI  - 6
IP  - 2
DP  - 2012 Jul-Dec
TI  - Orotracheal intubation of morbidly obese patients, comparison of GlideScope((R)) 
      video laryngoscope and the LMA CTrach with direct laryngoscopy.
PG  - 174-9
LID - 10.4103/0259-1162.108304 [doi]
AB  - BACKGROUND: Morbidly obese patients are at increased risk of difficult mask
      ventilation and intubation as well as increased risk of hypoxemia during tracheal
      intubation. Recently, new video-assisted intubation devices have been developed. 
      The GlideScope((R)) videolaryngoscope and LMA CTrach (CT) allows continuous
      video-endoscopy of the tracheal intubation procedure. OBJECTIVE: this study is to
      determine whether the GlideScope((R)) videolaryngoscope (GVL) and the LMA CTrach 
      (CT) provide the best airway management, measured primarily in intubation
      difficulty scale (IDS) scores, time and numbers of intubation attempts, and
      improvement in the intubation success rate of morbidly obese patients when
      compared with the direct Macintosh laryngoscope (DL). MATERIALS AND METHODS:
      After Ethics' Committee approval, 90 morbidly obese patients (BMI > 35 kg/m(2))
      scheduled for general, gynecological, and bariatric surgery were included in this
      prospective study. Patients were randomly assigned in three groups: tracheal
      intubation using direct laryngoscopy (DL), GlideScope((R)) videolaryngoscope
      (GVL) or the LMA CTrach (CT). Characteristics and consequences of airway
      management were evaluated. The primary outcome was the intubation difficulty
      scale score (IDS), Secondary outcomes were theintubation time, overall success
      rate, number of attempts, Cormack-Lehane grade, subjective difficulty of
      intubation, desaturation and upper airway morbidity. RESULTS: Difficulty in
      facemask ventilation was similar in the three groups. IDS scores were
      significantly lower with GVL and CT than with DL. The mean TTI was 14 s faster in
      patients intubated with the GVL (86 s, IQR: 68-115) compared with DL (100 s, IQR;
      80-150), and was 34 s faster when compared with CT (120 s, IQR; 95-180). The
      success rate of tracheal intubation was lower with the DL (80%) compared with the
      GVL (100%) or the CT (100%). Six cases of failed intubation occurred in group DL,
      four patients from the six patients were intubated successfully with GVL, and two
      patients were intubated with the CT. Both the GVL and the CTimproved the Cormack 
      and Lehane view obtained at laryngoscopy, compared with the DL. Significantly
      high percent of patients in DL (43%) and CT (27%) required optimization maneuvers
      (external laryngeal pressure) compared with GVL (0%). In the CT group, 30% of the
      patients required laryngeal mask manipulation (for view optimization) compared
      with (0%) in GVL and CT groups. CONCLUSION: The GlideScope((R)) videolaryngoscope
      and the LMA CTrach reduced the difficulty, improved laryngoscopic views and
      overall success rate of tracheal Intubationto a similar extent compared with the 
      Macintosh laryngoscope in morbidly obese patients. The GVL improved intubation
      time for tracheal intubation compared with the CT and DL but no patient became
      hypoxic with CT because of prolonged intubation time.
FAU - Yousef, Gamal T
AU  - Yousef GT
AD  - Department of Anesthesia and Intensive Care, Faculty of Medicine, Zagazig
      University, Zagazig, Egypt.
FAU - Abdalgalil, Dief A
AU  - Abdalgalil DA
AD  - Department of Anesthesia and Intensive Care, Faculty of Medicine, Zagazig
      University, Zagazig, Egypt.
FAU - Ibrahim, Tamer H
AU  - Ibrahim TH
AD  - Department of Anesthesia and Intensive Care, Faculty of Medicine, Zagazig
      University, Zagazig, Egypt.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Anesth Essays Res
JT  - Anesthesia, essays and researches
JID - 101578762
PMC - PMC4173448
OTO - NOTNLM
OT  - GlideScope(R) videolaryngoscope
OT  - LMA CTrach
OT  - Macintosh laryngoscope
OT  - morbid obese patients
OT  - tracheal intubation
EDAT- 2012/07/01 00:00
MHDA- 2012/07/01 00:01
CRDT- 2015/04/18 06:00
PHST- 2015/04/18 06:00 [entrez]
PHST- 2012/07/01 00:00 [pubmed]
PHST- 2012/07/01 00:01 [medline]
AID - 10.4103/0259-1162.108304 [doi]
AID - AER-6-174 [pii]
PST - ppublish
SO  - Anesth Essays Res. 2012 Jul-Dec;6(2):174-9. doi: 10.4103/0259-1162.108304.


PMID- 25885609
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150418
LR  - 20220408
IS  - 0259-1162 (Print)
IS  - 2229-7685 (Linking)
VI  - 6
IP  - 2
DP  - 2012 Jul-Dec
TI  - Assessment of the subglottic region by ultrasonography for estimation of
      appropriate size endotracheal tube: A clinical prospective study.
PG  - 157-60
LID - 10.4103/0259-1162.108298 [doi]
AB  - BACKGROUND: Endotracheal intubation is important to carry out various surgical
      procedures. The estimation of endotracheal tube size is governed by narrowest
      diameter of the upper airway. The objective of the study was to assess the
      narrowest tracheal diameter by ultrasound for selection of the appropriate size
      endotracheal tube. MATERIALS AND METHODS: After the approval of institution
      ethical committee and written informed consent, 112 patients aged 3 to 18 years
      of both genders with normal airways, scheduled for surgery under general
      anesthesia and intubation, were enrolled for this prospective clinical
      observational study. Preanesthetic ultrasonography of the subglottic region was
      performed by experienced ultrasonologist with a high-resolution linear array
      transducer in sniffing position for every patient and the subglottic tracheal
      diameter was estimated to select the appropriate-size endotracheal tube. The
      endotracheal tube, calculated on the basis of physical indices and by ultrasound,
      was statistically correlated with the appropriate size endotracheal tube used
      clinically for intubation. RESULTS: The ultrasound guided selection criterion has
      estimated the appropriate-sized endotracheal tube better than physical indices
      (age or height)-based formulas. The estimated endotracheal tube size by
      ultrasound was significantly correlated with the clinically used endotracheal
      tube. CONCLUSION: Ultrasonography may be used for the assessment of the
      subglottic diameter of trachea in children to estimate the appropriate size
      endotracheal tube for intubation.
FAU - Gupta, Kumkum
AU  - Gupta K
AD  - Department of Anaesthesiology and Critical Care, N.S.C.B. Subharti Medical
      College, Subhartipuram, NH-58, Meerut, Uttar Pradesh, India.
FAU - Gupta, Prashant K
AU  - Gupta PK
AD  - Department of Radio diagnosis, Imaging and Interventional Radiology, N.S.C.B.
      Subharti Medical College, Subhartipuram, NH-58, Meerut, Uttar Pradesh, India.
FAU - Rastogi, Bhawna
AU  - Rastogi B
AD  - Department of Anaesthesiology and Critical Care, N.S.C.B. Subharti Medical
      College, Subhartipuram, NH-58, Meerut, Uttar Pradesh, India.
FAU - Krishan, Atul
AU  - Krishan A
AD  - Department of Surgery, N.S.C.B. Subharti Medical College, Subhartipuram, NH-58,
      Meerut, Uttar Pradesh, India.
FAU - Jain, Manish
AU  - Jain M
AD  - Department of Anaesthesiology and Critical Care, N.S.C.B. Subharti Medical
      College, Subhartipuram, NH-58, Meerut, Uttar Pradesh, India.
FAU - Garg, Gouri
AU  - Garg G
AD  - Department of Radio diagnosis, Imaging and Interventional Radiology, N.S.C.B.
      Subharti Medical College, Subhartipuram, NH-58, Meerut, Uttar Pradesh, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Anesth Essays Res
JT  - Anesthesia, essays and researches
JID - 101578762
PMC - PMC4173447
OTO - NOTNLM
OT  - Endotracheal tube
OT  - subglottic diameter
OT  - ultrasound
OT  - upper airway
EDAT- 2012/07/01 00:00
MHDA- 2012/07/01 00:01
CRDT- 2015/04/18 06:00
PHST- 2015/04/18 06:00 [entrez]
PHST- 2012/07/01 00:00 [pubmed]
PHST- 2012/07/01 00:01 [medline]
AID - 10.4103/0259-1162.108298 [doi]
AID - AER-6-157 [pii]
PST - ppublish
SO  - Anesth Essays Res. 2012 Jul-Dec;6(2):157-60. doi: 10.4103/0259-1162.108298.


PMID- 25885602
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150418
LR  - 20200929
IS  - 0259-1162 (Print)
IS  - 2229-7685 (Linking)
VI  - 6
IP  - 2
DP  - 2012 Jul-Dec
TI  - Ethics in medical writing.
PG  - 113-4
LID - 10.4103/0259-1162.108282 [doi]
FAU - Bithal, Parmod Kumar
AU  - Bithal PK
AD  - Consultant Anesthesia (sub specialty), Department of Anesthesia, King Fahd
      Medical City, Riyadh, Saudi Arabia. E-mail: bithal.parmod@gmail.com.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Anesth Essays Res
JT  - Anesthesia, essays and researches
JID - 101578762
PMC - PMC4173457
EDAT- 2012/07/01 00:00
MHDA- 2012/07/01 00:01
CRDT- 2015/04/18 06:00
PHST- 2015/04/18 06:00 [entrez]
PHST- 2012/07/01 00:00 [pubmed]
PHST- 2012/07/01 00:01 [medline]
AID - 10.4103/0259-1162.108282 [doi]
AID - AER-6-113 [pii]
PST - ppublish
SO  - Anesth Essays Res. 2012 Jul-Dec;6(2):113-4. doi: 10.4103/0259-1162.108282.


PMID- 24669615
OWN - NLM
STAT- MEDLINE
DCOM- 20140520
LR  - 20140327
IS  - 1025-9589 (Print)
IS  - 1025-9589 (Linking)
VI  - 24
IP  - 3-4
DP  - 2012 Jul-Dec
TI  - Quantity and quality of information, education and communication during antenatal
      visit at private and public sector hospitals of Bahawalpur, Pakistan.
PG  - 71-4
AB  - BACKGROUND: Information, education and communication (IEC) by health care
      provider to pregnant woman during the antenatal visit are very crucial for
      healthier outcome of pregnancy. This study analysed the quality and quantity of
      antenatal visit at a private and a public hospital of Bahawalpur, Pakistan.
      METHODS: An exit interview was conducted from 216 pregnant women by using
      validated, reliable and pre-tested adapted questionnaire. First sample was
      selected by simple random sampling, for rest of the sample selection systematic
      random sampling was adapted by selecting every 7th women for interview. Ethical
      considerations were taken. RESULTS: Average communication time among pregnant
      woman and her healthcare provider was 3 minute in public and 8 minutes in private
      hospital. IEC mainly focused on diet and nutrition in private (86%) and (53%)
      public, advice for family planning after delivery was discussed with 13% versus
      7% in public and private setting. None of the respondents in both facilities got 
      advice or counselling on breastfeeding and neonatal care. Birth preparedness
      components were discussed, woman in public and private hospital respectively. In 
      both settings antenatal clients were not received information and education
      communication according to World Health Organization guidelines. CONCLUSION:
      Quality and quantity of IEC during antenatal care was found very poor in both
      public and private sector hospitals of urban Pakistan.
FAU - Mahar, Benazeer
AU  - Mahar B
FAU - Kumar, Ramesh
AU  - Kumar R
FAU - Rizvi, Narjis
AU  - Rizvi N
FAU - Bahalkani, Habib Akhtar
AU  - Bahalkani HA
FAU - Haq, Mahboobul
AU  - Haq M
FAU - Soomro, Jamila
AU  - Soomro J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Pakistan
TA  - J Ayub Med Coll Abbottabad
JT  - Journal of Ayub Medical College, Abbottabad : JAMC
JID - 8910750
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cross-Sectional Studies
MH  - Female
MH  - Hospitals, Private/*standards/statistics & numerical data
MH  - Hospitals, Public/*standards/statistics & numerical data
MH  - Humans
MH  - Pakistan
MH  - Patient Education as Topic/*standards
MH  - Pregnancy
MH  - Prenatal Care/*standards
MH  - *Professional-Patient Relations
EDAT- 2012/07/01 00:00
MHDA- 2014/05/21 06:00
CRDT- 2014/03/28 06:00
PHST- 2014/03/28 06:00 [entrez]
PHST- 2012/07/01 00:00 [pubmed]
PHST- 2014/05/21 06:00 [medline]
PST - ppublish
SO  - J Ayub Med Coll Abbottabad. 2012 Jul-Dec;24(3-4):71-4.


PMID- 24564095
OWN - NLM
STAT- MEDLINE
DCOM- 20140403
LR  - 20151119
IS  - 0189-2657 (Print)
IS  - 0189-2657 (Linking)
VI  - 22
IP  - 3
DP  - 2012 Jul-Sep
TI  - Effect of health education on knowledge, attitude and practices of personal
      hygiene among secondary school students in rural Sokoto, North West, Nigeria.
PG  - 181-90
AB  - BACKGROUND: Personal hygiene related diseases are serious public health problems 
      in developing countries. OBJECTIVE: To assess the effect of health education on
      knowledge, attitude, and practices of personal hygiene among rural secondary
      school students in Sokoto state, north western Nigeria. METHODS: A
      quasi-experimental controlled study with pretest and post-test design was carried
      out. A total 120 subjects per group were selected by multistage sampling
      technique. Two pre-tested instruments, structured interviewer-administered
      questionnaire and observer's checklist for personal hygiene practices were used
      for data collection. Health education intervention was carried out one week after
      baseline data collection and repeated after four weeks for the intervention group
      only. Postintervention data collection was carried out in both intervention and
      control groups three months after the 2nd intervention. However, for ethical
      consideration, the control group was also provided with the health education
      intervention similar to that provided to the intervention group. RESULTS: A total
      of 120 and 116 subjects in the intervention and control groups respectively
      participated in all phases of the study. The mean knowledge score (%) of the
      study subjects was high and similar (73.18 +/- 25.82; 77.06 +/- 21.79; p = 0.21) 
      in both the intervention and control groups at baseline, but differed very
      significantly (91.16 +/- 11.03; 81.74 +/- 21.78; p < 0.0001) at
      post-intervention. The mean attitude score (%) was high but differ significantly 
      (82.6 +/- 12.73; 86.38 +/- 10.74; p = 0.01) between the intervention and control 
      groups at baseline, and further differed very significantly (95.5 +/- 3.66; 86.90
      +/- 10.44; p < 0.0001) at post intervention. The mean reported practice score (%)
      was high but differ significantly (94.86 +/- 3.00; 93.25 +/- 6.31; p = 0.01)
      between the intervention and control groups at baseline, and further differed
      very significantly (96.68 +/- 4.08; 93.7 +/- 6.28; p < 0.0001) at
      post-intervention. The mean observed practice score (%) was high and similar
      (57.50 +/- 29.65; 61.35 +/- 28.49; p = 0.31) in both the intervention and control
      groups at baseline, but differed very significantly (88.20 +/- 9.99; 62.10 +/-
      26.94; p < 0.0001) at post-intervention. CONCLUSION: Health education
      intervention had impact on knowledge base, attitude and practice of study
      subjects in intervention group compared to control group. Personal hygiene health
      education is therefore recommended to be taught in secondary schools.
FAU - Abiola, A O
AU  - Abiola AO
AD  - Department of Community Health and Primary Care, College of Medicine of the
      University of Lagos, P.M.B. 12003 Lagos, Nigeria. aoabi@yahoo.co.uk
FAU - Nwogu, E E
AU  - Nwogu EE
AD  - Tangaza General Hospital, Tangaza Local Government Area, Sokoto state.
FAU - Ibrahim, M T O
AU  - Ibrahim MT
AD  - Department of Community Health, College of Health Sciences, Usmanu Danfodiyo
      University Sokoto.
FAU - Hassan, R
AU  - Hassan R
AD  - Department of Ophthalmology, College of Health Sciences, Usmanu Danfodiyo
      University Sokoto.
LA  - eng
PT  - Journal Article
PL  - Nigeria
TA  - Nig Q J Hosp Med
JT  - Nigerian quarterly journal of hospital medicine
JID - 9713944
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Checklist
MH  - Child
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Hygiene/*education
MH  - Male
MH  - Nigeria
MH  - Rural Population
MH  - *School Health Services
MH  - Surveys and Questionnaires
EDAT- 2012/07/01 00:00
MHDA- 2014/04/04 06:00
CRDT- 2014/02/26 06:00
PHST- 2014/02/26 06:00 [entrez]
PHST- 2012/07/01 00:00 [pubmed]
PHST- 2014/04/04 06:00 [medline]
PST - ppublish
SO  - Nig Q J Hosp Med. 2012 Jul-Sep;22(3):181-90.


PMID- 24027394
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20211021
IS  - 1117-6806 (Print)
IS  - 1117-6806 (Linking)
VI  - 18
IP  - 2
DP  - 2012 Jul
TI  - Organ transplantation: legal, ethical and islamic perspective in Nigeria.
PG  - 53-60
LID - 10.4103/1117-6806.103103 [doi]
AB  - Organ transplantation dates back to the ancient times and since then it has
      become one of the important developments in modern medicine; saving the lives, as
      well as improving the quality of life of many patients. As the demand for organ
      transplantation far exceeds the organ availability, the transplant program is
      often saddled with complex legal and ethical issues. This review article
      highlights the legal and ethical issues that might arise regarding organ
      transplantation and appraises the existing legal frame work governing organ
      transplantation in Nigeria. Information on legal, cultural, religious and medical
      ethical issues regarding organ transplantation in Nigeria was obtained by
      searching the PubMed and Google Scholar, conference proceedings, seminar paper
      presentations, law library and other related publications were collated and
      analyzed. In decision making for organ transplantation, the bioethical principles
      like autonomy, beneficence and justice must be employed. It was believed by
      Catholic theologians that to mutilate one living person to benefit another
      violates the principle of Totality. Among Muslim scholars and researchers, there 
      are those who throw legal support as to its permissibility while the other group 
      sees it as illegal. Organ/tissues transplantation is considered a medical
      intervention that touches on the fundamental rights of the donor or the
      recipient. Where there is an unlawful infringement of the right of such persons
      in any way may be regarded as against Section 34 of the 1999 Nigerian
      Constitution dealing with right to dignity of the human person. Worldwide, the
      researchers and government bodies have agreed on informed consent for
      organ/tissue donation and for recipient should be obtained without coercion
      before embarking on such medical treatment Worldwide organ transplantation has
      become the best medical treatment for patients with end stage organ failure.
      However, there is no law/legislation backing organ/tissues transplantation in
      Nigeria. The government should take measures to combat transplantation tourism
      and the problem of national and international trafficking in human tissues and
      organs, ethics commission and National Transplant registry should be established 
      in order to monitor and regulate the programme in the country.
FAU - Bakari, Abubakar A
AU  - Bakari AA
AD  - Department of Surgery, University of Maiduguri, Maiduguri, Nigeria.
FAU - Abbo Jimeta, Umar S
AU  - Abbo Jimeta US
FAU - Abubakar, Mohammed A
AU  - Abubakar MA
FAU - Alhassan, Sani U
AU  - Alhassan SU
FAU - Nwankwo, Emeka A
AU  - Nwankwo EA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - India
TA  - Niger J Surg
JT  - Nigerian journal of surgery : official publication of the Nigerian Surgical
      Research Society
JID - 101189891
PMC - PMC3762001
OTO - NOTNLM
OT  - Ethical
OT  - Islamic perspective
OT  - Nigeria
OT  - legal
OT  - organ transplantation
EDAT- 2012/07/01 00:00
MHDA- 2012/07/01 00:01
CRDT- 2013/09/13 06:00
PHST- 2013/09/13 06:00 [entrez]
PHST- 2012/07/01 00:00 [pubmed]
PHST- 2012/07/01 00:01 [medline]
AID - 10.4103/1117-6806.103103 [doi]
AID - NJS-18-53 [pii]
PST - ppublish
SO  - Niger J Surg. 2012 Jul;18(2):53-60. doi: 10.4103/1117-6806.103103.


PMID- 22745653
OWN - NLM
STAT- MEDLINE
DCOM- 20121130
LR  - 20220310
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 6
DP  - 2012
TI  - Derivation of xeno-free and GMP-grade human embryonic stem cells--platforms for
      future clinical applications.
PG  - e35325
LID - 10.1371/journal.pone.0035325 [doi]
AB  - Clinically compliant human embryonic stem cells (hESCs) should be developed in
      adherence to ethical standards, without risk of contamination by adventitious
      agents. Here we developed for the first time animal-component free and good
      manufacturing practice (GMP)-compliant hESCs. After vendor and raw material
      qualification, we derived xeno-free, GMP-grade feeders from umbilical cord
      tissue, and utilized them within a novel, xeno-free hESC culture system. We
      derived and characterized three hESC lines in adherence to regulations for embryo
      procurement, and good tissue, manufacturing and laboratory practices. To minimize
      freezing and thawing, we continuously expanded the lines from initial outgrowths 
      and samples were cryopreserved as early stocks and banks. Batch release criteria 
      included DNA-fingerprinting and HLA-typing for identity, characterization of
      pluripotency-associated marker expression, proliferation, karyotyping and
      differentiation in-vitro and in-vivo. These hESCs may be valuable for
      regenerative therapy. The ethical, scientific and regulatory methodology
      presented here may serve for development of additional clinical-grade hESCs.
FAU - Tannenbaum, Shelly E
AU  - Tannenbaum SE
AD  - Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Medical
      Center, Jerusalem, Israel.
FAU - Turetsky, Tikva Tako
AU  - Turetsky TT
FAU - Singer, Orna
AU  - Singer O
FAU - Aizenman, Einat
AU  - Aizenman E
FAU - Kirshberg, Sophie
AU  - Kirshberg S
FAU - Ilouz, Nili
AU  - Ilouz N
FAU - Gil, Yaniv
AU  - Gil Y
FAU - Berman-Zaken, Yael
AU  - Berman-Zaken Y
FAU - Perlman, Temima Schnitzer
AU  - Perlman TS
FAU - Geva, Nitshia
AU  - Geva N
FAU - Levy, Ora
AU  - Levy O
FAU - Arbell, Daniel
AU  - Arbell D
FAU - Simon, Alex
AU  - Simon A
FAU - Ben-Meir, Assaf
AU  - Ben-Meir A
FAU - Shufaro, Yoel
AU  - Shufaro Y
FAU - Laufer, Neri
AU  - Laufer N
FAU - Reubinoff, Benjamin E
AU  - Reubinoff BE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120620
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Cell Culture Techniques/ethics/*methods
MH  - Embryonic Stem Cells/*cytology
MH  - Humans
PMC - PMC3380026
EDAT- 2012/06/30 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/06/30 06:00
PHST- 2012/01/08 00:00 [received]
PHST- 2012/03/12 00:00 [accepted]
PHST- 2012/06/30 06:00 [entrez]
PHST- 2012/06/30 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1371/journal.pone.0035325 [doi]
AID - PONE-D-12-00789 [pii]
PST - ppublish
SO  - PLoS One. 2012;7(6):e35325. doi: 10.1371/journal.pone.0035325. Epub 2012 Jun 20.


PMID- 22745620
OWN - NLM
STAT- MEDLINE
DCOM- 20120928
LR  - 20220629
IS  - 1552-5775 (Electronic)
IS  - 1552-5767 (Linking)
VI  - 16
IP  - 2
DP  - 2012 Spring
TI  - The familiar foundation and the fuller sense: ethics consultation and narrative.
PG  - 60-3
AB  - As clinical ethicists and ethics committee members, we strive to create the ideal
      situation for moral conversation and ethical reflection. Using both the familiar 
      foundation and the fuller sense, the ethicist and ethics committee are aided in
      participating more fruitfully in a process of resolution. The familiar foundation
      represents a body of knowledge that ethics consultants and ethics committees
      should thoroughly understand. In addition, there is a depth of analysis found in 
      the fuller sense, through narrative, that sharpens ethical focus and enables
      richer understanding of the patient's situation in life. In using both tools,
      patients and families are better served than they would be relying on either tool
      by itself. Stakeholders and their relationships become more clearly assessed and 
      individuals more effectively discover their own legitimate position. This can
      mean a more thorough representation of moral problems, a deeper understanding of 
      all parties involved, and a greater opportunity to help parties better understand
      themselves and each other.
FAU - Nelson, Craig
AU  - Nelson C
AD  - South Bay Medical Center, Harbor City, CA, USA. craig.m.nelson@kp.org
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Perm J
JT  - The Permanente journal
JID - 9800474
SB  - IM
MH  - Communication
MH  - Decision Making
MH  - Ethics Committees, Clinical
MH  - *Ethics Consultation
MH  - *Ethics, Medical
MH  - Humans
MH  - Professional-Family Relations
MH  - Professional-Patient Relations
PMC - PMC3383166
EDAT- 2012/06/30 06:00
MHDA- 2012/09/29 06:00
CRDT- 2012/06/30 06:00
PHST- 2012/06/30 06:00 [entrez]
PHST- 2012/06/30 06:00 [pubmed]
PHST- 2012/09/29 06:00 [medline]
AID - 10.7812/TPP/11-150 [doi]
PST - ppublish
SO  - Perm J. 2012 Spring;16(2):60-3. doi: 10.7812/TPP/11-150.


PMID- 22745361
OWN - NLM
STAT- MEDLINE
DCOM- 20130101
LR  - 20120809
IS  - 1049-7323 (Print)
IS  - 1049-7323 (Linking)
VI  - 22
IP  - 9
DP  - 2012 Sep
TI  - Art and science in health care research: pushing at open doors or locked in
      institutions?
PG  - 1176-83
LID - 10.1177/1049732312449206 [doi]
AB  - Research methods are usually dictated and driven by the research question. In the
      context of research in "closed" systems--for example, offender health
      settings--it is imperative that the research question takes into consideration
      the context in which the research is located. Conducting research that has
      action, transformation, and creativity at its heart is a significant challenge in
      closed cultures, for both the researcher and the researched. Using two exemplars,
      we question whether researchers should adopt a safe approach to researching these
      closed cultures and to what extent they should engage in methodological tensions 
      and ethical dilemmas that provoke and support reflection on change. By reflecting
      on our previous research studies, we aim not so much to provide a definitive
      answer to this question but to suggest that researchers give careful
      consideration to the methods appropriate to both the context of the research and 
      its purpose.
FAU - Freshwater, Dawn
AU  - Freshwater D
AD  - University of Leeds, Leeds, UK. d.s.freshwater@adm.leeds.ac.uk
FAU - Cahill, Jane
AU  - Cahill J
FAU - Walsh, Elizabeth
AU  - Walsh E
FAU - Muncey, Tessa
AU  - Muncey T
FAU - Esterhuizen, Philip
AU  - Esterhuizen P
LA  - eng
PT  - Journal Article
DEP - 20120628
PL  - United States
TA  - Qual Health Res
JT  - Qualitative health research
JID - 9202144
MH  - *Art
MH  - *Ethics, Research
MH  - Health Services Research/*methods
MH  - Humans
MH  - Organizational Culture
MH  - *Prisoners
MH  - *Prisons
MH  - Research Design
MH  - *Science
EDAT- 2012/06/30 06:00
MHDA- 2013/01/02 06:00
CRDT- 2012/06/30 06:00
PHST- 2012/06/30 06:00 [entrez]
PHST- 2012/06/30 06:00 [pubmed]
PHST- 2013/01/02 06:00 [medline]
AID - 1049732312449206 [pii]
AID - 10.1177/1049732312449206 [doi]
PST - ppublish
SO  - Qual Health Res. 2012 Sep;22(9):1176-83. doi: 10.1177/1049732312449206. Epub 2012
      Jun 28.


PMID- 22745109
OWN - NLM
STAT- MEDLINE
DCOM- 20141020
LR  - 20150721
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 40
IP  - 3
DP  - 2014 Mar
TI  - Imposing options on people in poverty: the harm of a live donor organ market.
PG  - 145-50
LID - 10.1136/medethics-2011-100318 [doi]
AB  - A prominent defence of a market in organs from living donors says that if we
      truly care about people in poverty, we should allow them to sell their organs.
      The argument is that if poor vendors would have voluntarily decided to sell their
      organs in a free market, then prohibiting them from selling makes them even worse
      off, at least from their own perspective, and that it would be unconscionably
      paternalistic to substitute our judgements for individuals' own judgements about 
      what would be best for them. The author shows that this 'Laissez-Choisir
      Argument' for organ selling rests on a mistake. This is because the claim that it
      would be better for people in poverty to sell their organs if given the option is
      consistent with the claim that it would be even better for them to not have the
      option at all. The upshot is that objections to an organ market need not be at
      all paternalistic, since we need not accept that the absence of a market makes
      those in poverty any worse off, even from their own point of view. The author
      goes on to argue that there are strong theoretical and empirical reasons for
      believing that people in poverty would in fact be harmed by the introduction of a
      market for live donor organs and that the harm constitutes sufficient grounds for
      prohibiting a market.
FAU - Rippon, Simon
AU  - Rippon S
LA  - eng
PT  - Journal Article
DEP - 20120628
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
CIN - J Med Ethics. 2014 Mar;40(3):151-2. PMID: 22718855
CIN - J Med Ethics. 2014 Mar;40(3):153-4. PMID: 22751956
CIN - J Med Ethics. 2014 Mar;40(3):152-3. PMID: 23087186
CIN - J Med Ethics. 2015 Jun;41(6):443-6. PMID: 25256300
MH  - Altruism
MH  - Choice Behavior
MH  - Commerce/*ethics
MH  - Commodification
MH  - *Decision Making
MH  - Human Body
MH  - Humans
MH  - *Living Donors/ethics/psychology
MH  - Morals
MH  - Paternalism/*ethics
MH  - *Personal Autonomy
MH  - *Poverty
MH  - *Social Justice
MH  - Tissue and Organ Procurement/*ethics
MH  - *Vulnerable Populations
OTO - NOTNLM
OT  - Tissue and organ procurement
OT  - bioethics
OT  - commerce
OT  - ethics
OT  - philosophical ethics
OT  - tissue donors
EDAT- 2012/06/30 06:00
MHDA- 2014/10/21 06:00
CRDT- 2012/06/30 06:00
PHST- 2012/06/30 06:00 [entrez]
PHST- 2012/06/30 06:00 [pubmed]
PHST- 2014/10/21 06:00 [medline]
AID - medethics-2011-100318 [pii]
AID - 10.1136/medethics-2011-100318 [doi]
PST - ppublish
SO  - J Med Ethics. 2014 Mar;40(3):145-50. doi: 10.1136/medethics-2011-100318. Epub
      2012 Jun 28.


PMID- 22745108
OWN - NLM
STAT- MEDLINE
DCOM- 20130104
LR  - 20220309
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 10
DP  - 2012 Oct
TI  - Ethical considerations for choosing between possible models for using NIPD for
      aneuploidy detection.
PG  - 614-8
AB  - Recent scientific advances mean the widespread introduction of non-invasive
      prenatal diagnosis (NIPD) for chromosomal aneuploidies may be close at hand,
      raising the question of how NIPD should be introduced as part of antenatal care
      pathways for pregnant women. In this paper, the authors examine the ethical
      implications of three hypothetical models for using NIPD for aneuploidy in
      state-funded healthcare systems and assess which model is ethically preferable.
      In comparing the models, the authors consider their respective timings; how each 
      model would fit with current screening and diagnostic tests offered to pregnant
      women; the implications of offering NIPD at different stages of pregnancy; and
      the potential for each model to support reproductive autonomy and informed
      decision-making. The authors conclude by favouring a model that would be offered 
      at 11-13 weeks gestation, alongside existing combined screening, provided that
      this is accompanied by measures to maximise informed decision-making, for
      example, provision of adequate pretest and post-test counselling.
FAU - Deans, Zuzana
AU  - Deans Z
AD  - Centre for Ethics in Medicine, School of Social and Community Medicine,
      University of Bristol, 39 Whatley Road, Bristol BS8 2PS, UK.
      zuzana.deans@bristol.ac.uk
FAU - Newson, Ainsley Janelle
AU  - Newson AJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120628
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Adult
MH  - *Aneuploidy
MH  - Chromosome Disorders/diagnosis/genetics
MH  - Chromosomes, Human, Pair 13/genetics
MH  - Chromosomes, Human, Pair 18
MH  - Decision Making/*ethics
MH  - Down Syndrome/diagnosis/genetics
MH  - Female
MH  - Genetic Testing/*ethics/*methods
MH  - Humans
MH  - Pregnancy
MH  - Prenatal Diagnosis/*ethics/*methods
MH  - Trisomy/diagnosis/genetics
MH  - Trisomy 13 Syndrome
EDAT- 2012/06/30 06:00
MHDA- 2013/01/05 06:00
CRDT- 2012/06/30 06:00
PHST- 2012/06/30 06:00 [entrez]
PHST- 2012/06/30 06:00 [pubmed]
PHST- 2013/01/05 06:00 [medline]
AID - medethics-2011-100180 [pii]
AID - 10.1136/medethics-2011-100180 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Oct;38(10):614-8. doi: 10.1136/medethics-2011-100180. Epub
      2012 Jun 28.


PMID- 22744445
OWN - NLM
STAT- MEDLINE
DCOM- 20130627
LR  - 20220317
IS  - 1438-8782 (Electronic)
IS  - 0172-4614 (Linking)
VI  - 33
IP  - 7
DP  - 2012 Dec
TI  - Preoperative T staging of advanced gastric cancer using double contrast-enhanced 
      ultrasound.
PG  - E218-E224
LID - 10.1055/s-0032-1312958 [doi]
AB  - PURPOSE: To determine the accuracy of double contrast-enhanced ultrasound
      (DCEUS), in which intravenous microbubbles are used together with an oral
      contrast agent, in the preoperative T staging of advanced gastric cancer.
      MATERIALS AND METHODS: This prospective, ethics committee-approved study
      recruited 350 patients who gave informed consent. All had gastric cancer proved
      by endoscopic biopsy and underwent preoperative ultrasound staging using the TNM 
      classification (UICC 2002). The results of DCEUS were compared with postoperative
      pathologic findings. The staging accuracy of oral contrast-enhanced ultrasound
      (OCEUS) and DCEUS were compared to each other. Sensitivity and specificity for
      assessing serosal involvement by DCEUS were evaluated, and the concordance of
      this method was analyzed using Kappa statistics. RESULTS: The accuracies of OCEUS
      and DCEUS in determining the T stage of advanced gastric cancer were 75.1 % (70.4
      % for T2, 79.5 % for T3, 68.1 % for T4) and 87.4 % (83.3 % for T2, 89.7 % for T3,
      87.2 % for T4), respectively, and the difference between the two methods was
      statistically significant (chi2 = 17.364, p< 0.001). The performance of DCEUS for
      staging lesions in the cardia (69.81 %), fundus (85.71 %) and body (85.56 %) had 
      lower accuracy than that of other parts (93.94 % for antrum; 92.11 % for
      pylorus). Sensitivity and specificity for assessing serosal involvement by DCEUS 
      were 98.76 % and 83.33 % respectively. The reliability was almost perfect with
      Kappa values of 0.89 (p< 0.001) for intra-observer and 0.82 (p< 0.001) for
      inter-observer agreement. CONCLUSION: DCEUS could be considered as an accurate,
      non-invasive, and reliable diagnostic method for preoperative staging of advanced
      gastric cancer.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Li, S
AU  - Li S
AD  - Department of Diagnostic Ultrasound and Echocardiography, Sir Run Run Shaw
      Hospital, Zhejiang University College of Medicine.
FAU - Huang, P
AU  - Huang P
AD  - Department of Ultrasonography, the 2nd Affiliated Hospital Zhejiang University
      College of Medicine.
FAU - Wang, Z
AU  - Wang Z
AD  - Department of Pathology, the 2nd Affiliated Hospital of Wenzhou Medical College.
FAU - Chen, J
AU  - Chen J
AD  - Department of General Surgery, the 2nd Affiliated Hospital Zhejiang University
      College of Medicine.
FAU - Xu, H
AU  - Xu H
AD  - Department of Diagnostic Ultrasound and Echocardiography, Sir Run Run Shaw
      Hospital, Zhejiang University College of Medicine.
FAU - Wang, L
AU  - Wang L
AD  - Department of Ultrasonography, the 2nd Affiliated Hospital of Wenzhou Medical
      College.
FAU - Zhang, Y
AU  - Zhang Y
AD  - Department of Ultrasonography, the 2nd Affiliated Hospital Zhejiang University
      College of Medicine.
FAU - Mo, G
AU  - Mo G
AD  - Department of Ultrasonography, the 2nd Affiliated Hospital Zhejiang University
      College of Medicine.
FAU - Zhu, J
AU  - Zhu J
AD  - Department of Ultrasonography, the 2nd Affiliated Hospital Zhejiang University
      College of Medicine.
FAU - Cosgrove, D
AU  - Cosgrove D
AD  - Imaging Sciences Department, Imperial College, Hammersmith Hospital.
LA  - eng
PT  - Journal Article
DEP - 20120628
PL  - Germany
TA  - Ultraschall Med
JT  - Ultraschall in der Medizin (Stuttgart, Germany : 1980)
JID - 8303585
RN  - 0 (Contrast Media)
RN  - 0 (Phospholipids)
RN  - 0 (contrast agent BR1)
RN  - WS7LR3I1D6 (Sulfur Hexafluoride)
SB  - IM
MH  - Adenocarcinoma/blood supply/*diagnostic imaging/*pathology/surgery
MH  - Administration, Oral
MH  - Aged
MH  - Biopsy
MH  - Contrast Media/*administration & dosage
MH  - Female
MH  - Gastroscopy
MH  - Humans
MH  - Image Enhancement/*methods
MH  - Injections, Intravenous
MH  - Male
MH  - Microbubbles
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Neovascularization, Pathologic/diagnostic imaging/pathology/surgery
MH  - *Phospholipids
MH  - Sensitivity and Specificity
MH  - Stomach/blood supply/diagnostic imaging/pathology/surgery
MH  - Stomach Neoplasms/blood supply/*diagnostic imaging/*pathology/surgery
MH  - *Sulfur Hexafluoride
MH  - Ultrasonography
EDAT- 2012/06/30 06:00
MHDA- 2013/06/29 06:00
CRDT- 2012/06/30 06:00
PHST- 2012/06/30 06:00 [entrez]
PHST- 2012/06/30 06:00 [pubmed]
PHST- 2013/06/29 06:00 [medline]
AID - 10.1055/s-0032-1312958 [doi]
PST - ppublish
SO  - Ultraschall Med. 2012 Dec;33(7):E218-E224. doi: 10.1055/s-0032-1312958. Epub 2012
      Jun 28.


PMID- 22742993
OWN - NLM
STAT- MEDLINE
DCOM- 20131125
LR  - 20121127
IS  - 1768-319X (Electronic)
IS  - 0294-1260 (Linking)
VI  - 57
IP  - 6
DP  - 2012 Dec
TI  - [Advanced skin tumors (incurables?) of the cephalic extremity: surgical
      considerations].
PG  - 533-41
LID - 10.1016/j.anplas.2012.05.003 [doi]
LID - S0294-1260(12)00092-1 [pii]
AB  - Suggest a surgical thinking for a multidisciplinary problem is inevitably
      difficult. Nevertheless, through targeted clinical examples, we tried to
      prioritize our clinical and intellectual approach for advanced tumors of the
      cephalic extremity. In these cases, decisions can only be collegial, and respect 
      for the patient and his choices remain essential. Ultimately, we would argue this
      problematic, discussing successively the histological type, ethical concern with 
      regard to clinic, operability and reconstruction opportunities.
CI  - Copyright (c) 2012 Elsevier Masson SAS. All rights reserved.
FAU - Lauwers, F
AU  - Lauwers F
AD  - Service de chirurgie maxillofaciale et plastie de la face, CHU de Toulouse
      Purpan, France.
FAU - Chaput, B
AU  - Chaput B
FAU - Jalbert, F
AU  - Jalbert F
FAU - Garrido, I
AU  - Garrido I
FAU - Lopez, R
AU  - Lopez R
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Tumeurs cutanees evoluees (depassees ?) de l'extremite cephalique : reflexions
      chirurgicales.
DEP - 20120627
PL  - France
TA  - Ann Chir Plast Esthet
JT  - Annales de chirurgie plastique et esthetique
JID - 8305839
SB  - IM
CIN - Ann Chir Plast Esthet. 2012 Dec;57(6):634-5. PMID: 22959951
MH  - Carcinoma, Basal Cell/pathology/surgery
MH  - Carcinoma, Basosquamous/pathology/surgery
MH  - Carcinoma, Squamous Cell/pathology/surgery
MH  - Cooperative Behavior
MH  - Esthetics
MH  - Eye Neoplasms/pathology/secondary/surgery
MH  - Head and Neck Neoplasms/pathology/secondary/*surgery
MH  - Humans
MH  - Interdisciplinary Communication
MH  - Melanoma/pathology/surgery
MH  - Neoplasm Invasiveness
MH  - Neoplasm Staging
MH  - Orbit Evisceration
MH  - Prognosis
MH  - Reconstructive Surgical Procedures
MH  - Skin Neoplasms/*pathology/secondary/*surgery
MH  - Surgical Flaps
EDAT- 2012/06/30 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/06/30 06:00
PHST- 2012/03/11 00:00 [received]
PHST- 2012/05/18 00:00 [accepted]
PHST- 2012/06/30 06:00 [entrez]
PHST- 2012/06/30 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - S0294-1260(12)00092-1 [pii]
AID - 10.1016/j.anplas.2012.05.003 [doi]
PST - ppublish
SO  - Ann Chir Plast Esthet. 2012 Dec;57(6):533-41. doi: 10.1016/j.anplas.2012.05.003. 
      Epub 2012 Jun 27.


PMID- 22742889
OWN - NLM
STAT- MEDLINE
DCOM- 20130718
LR  - 20130204
IS  - 0035-3787 (Print)
IS  - 0035-3787 (Linking)
VI  - 169
IP  - 1
DP  - 2013 Jan
TI  - [Critical approach to clinical trials: difficulties of such research in Lebanon].
PG  - 84-7
LID - 10.1016/j.neurol.2012.03.012 [doi]
LID - S0035-3787(12)00817-X [pii]
AB  - Clinical trials represent new steps in the progress of knowledge. Yet in spite of
      all the norms, guidelines and good clinical practices established since 1947,
      trials are still being published which seem to be, but in fact are not,
      well-conducted. Experts in planning and analyzing trial results have determined
      the factors that may affect clinical investigations at different phases. Among
      articles published over the last 30 years selected from Medline, one-third were
      biased. These biased articles were cited 2034 times. Clinical trials are designed
      to improve the treatment of particular diseases and to reduce mortality and
      morbidity. Nevertheless, other factors still appear to have an essential
      influence on the way clinical trials are conducted. It is surprising to see how
      often trials conclude that the drug of the pharmaceutical company initiating the 
      study or funding it has the same efficiency, and sometimes is more efficient,
      than the drug it is being judged against. Perhaps, journals should objectively
      describe clinical trial protocols before publishing their results. Poor
      populations are still being abused by the pharmaceutical industry and more
      thought should be given to the notions of volunteers participating in trials and 
      the compensation they receive. In Lebanon, the majority of these difficulties are
      encountered not only in multicenter international trials but are also seen in the
      lack of requirements for minimum safety measures and ethical standards when
      conducting national and regional trials. These insufficiencies raise important
      questions concerning their real objective.
CI  - Copyright (c) 2012 Elsevier Masson SAS. All rights reserved.
FAU - Abou-Mrad, F
AU  - Abou-Mrad F
AD  - Service de neurologie, hopital Saint-Charles, Fayadieh, BP 40, 276 Baabda, Liban.
      fadiaboumrad@gmail.com
FAU - Herve, C
AU  - Herve C
FAU - Feingold, J
AU  - Feingold J
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Approche critique des essais therapeutiques : difficultes de ce type de recherche
      au Liban.
DEP - 20120627
PL  - France
TA  - Rev Neurol (Paris)
JT  - Revue neurologique
JID - 2984779R
SB  - IM
MH  - Clinical Trials as Topic/*methods
MH  - Clinical Trials, Phase I as Topic
MH  - Clinical Trials, Phase IV as Topic
MH  - Drug Industry
MH  - Humans
MH  - Lebanon
MH  - Pharmacovigilance
MH  - Publication Bias
MH  - Research Design
EDAT- 2012/06/30 06:00
MHDA- 2013/07/19 06:00
CRDT- 2012/06/30 06:00
PHST- 2012/01/25 00:00 [received]
PHST- 2012/03/01 00:00 [revised]
PHST- 2012/03/21 00:00 [accepted]
PHST- 2012/06/30 06:00 [entrez]
PHST- 2012/06/30 06:00 [pubmed]
PHST- 2013/07/19 06:00 [medline]
AID - S0035-3787(12)00817-X [pii]
AID - 10.1016/j.neurol.2012.03.012 [doi]
PST - ppublish
SO  - Rev Neurol (Paris). 2013 Jan;169(1):84-7. doi: 10.1016/j.neurol.2012.03.012. Epub
      2012 Jun 27.


PMID- 22742814
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20211021
IS  - 1744-8603 (Electronic)
IS  - 1744-8603 (Linking)
VI  - 8
DP  - 2012 Jun 28
TI  - Global health and national borders: the ethics of foreign aid in a time of
      financial crisis.
PG  - 19
LID - 10.1186/1744-8603-8-19 [doi]
AB  - BACKGROUND: The governments and citizens of the developed nations are
      increasingly called upon to contribute financially to health initiatives outside 
      their borders. Although international development assistance for health has grown
      rapidly over the last two decades, austerity measures related to the 2008 and
      2011 global financial crises may impact negatively on aid expenditures. The
      competition between national priorities and foreign aid commitments raises
      important ethical questions for donor nations. This paper aims to foster
      individual reflection and public debate on donor responsibilities for global
      health. METHODS: We undertook a critical review of contemporary accounts of
      justice. We selected theories that: (i) articulate important and widely held
      moral intuitions; (ii) have had extensive impact on debates about global justice;
      (iii) represent diverse approaches to moral reasoning; and (iv) present distinct 
      stances on the normative importance of national borders. Due to space limitations
      we limit the discussion to four frameworks. RESULTS: Consequentialist,
      relational, human rights, and social contract approaches were considered.
      Responsibilities to provide international assistance were seen as significant by 
      all four theories and place limits on the scope of acceptable national autonomy. 
      Among the range of potential aid foci, interventions for health enjoyed
      consistent prominence. The four theories concur that there are important ethical 
      responsibilities to support initiatives to improve the health of the worst off
      worldwide, but offer different rationales for intervention and suggest different 
      implicit limits on responsibilities. CONCLUSIONS: Despite significant theoretical
      disagreements, four influential accounts of justice offer important reasons to
      support many current initiatives to promote global health. Ethical argumentation 
      can complement pragmatic reasons to support global health interventions and
      provide an important foundation to strengthen collective action.
FAU - Johri, Mira
AU  - Johri M
AD  - Unite de Sante Internationale, Centre de Recherche du Centre Hospitalier de
      l'Universite de Montreal, Edifice St-Urbain 3875, Rue St-Urbain 5e Etage,
      Montreal, QC H2W 1V1, Canada. mira.johri@umontreal.ca
FAU - Chung, Ryoa
AU  - Chung R
FAU - Dawson, Angus
AU  - Dawson A
FAU - Schrecker, Ted
AU  - Schrecker T
LA  - eng
GR  - 79153/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120628
PL  - England
TA  - Global Health
JT  - Globalization and health
JID - 101245734
SB  - IM
MH  - Developed Countries
MH  - *Economic Recession
MH  - *Global Health
MH  - Human Rights
MH  - Humans
MH  - *International Cooperation
MH  - Internationality
MH  - Morals
MH  - Social Justice/*ethics
PMC - PMC3464702
EDAT- 2012/06/30 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/06/30 06:00
PHST- 2011/11/13 00:00 [received]
PHST- 2012/05/02 00:00 [accepted]
PHST- 2012/06/30 06:00 [entrez]
PHST- 2012/06/30 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 1744-8603-8-19 [pii]
AID - 10.1186/1744-8603-8-19 [doi]
PST - epublish
SO  - Global Health. 2012 Jun 28;8:19. doi: 10.1186/1744-8603-8-19.


PMID- 22742813
OWN - NLM
STAT- MEDLINE
DCOM- 20130213
LR  - 20121001
IS  - 1879-3061 (Electronic)
IS  - 1043-2760 (Linking)
VI  - 23
IP  - 10
DP  - 2012 Oct
TI  - Eggs come in from the cold.
PG  - 498-500
LID - 10.1016/j.tem.2012.05.010 [doi]
LID - S1043-2760(12)00090-2 [pii]
AB  - Eggs can be 'forever'. A longstanding goal in assisted reproductive technology
      (ART) has been realized at last, namely, cryopreservation of oocytes by
      vitrification technology. This breakthrough heralds benefits for infertility
      treatment, fertility preservation, and even postponement of reproduction but, as 
      so often with ARTs, new waves of technology draw ethical and societal concerns in
      their wake.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Gosden, Roger G
AU  - Gosden RG
AD  - Weill Cornell Medical College, New York, NY, USA. Roger.Gosden@cantab.net
FAU - Gosden, Lucinda L Veeck
AU  - Gosden LL
LA  - eng
PT  - Journal Article
DEP - 20120627
PL  - United States
TA  - Trends Endocrinol Metab
JT  - Trends in endocrinology and metabolism: TEM
JID - 9001516
SB  - IM
MH  - Cryopreservation
MH  - Female
MH  - Humans
MH  - Male
MH  - Oocytes/cytology
MH  - *Reproductive Techniques, Assisted
MH  - Vitrification
EDAT- 2012/06/30 06:00
MHDA- 2013/02/14 06:00
CRDT- 2012/06/30 06:00
PHST- 2012/05/19 00:00 [received]
PHST- 2012/05/26 00:00 [accepted]
PHST- 2012/06/30 06:00 [entrez]
PHST- 2012/06/30 06:00 [pubmed]
PHST- 2013/02/14 06:00 [medline]
AID - S1043-2760(12)00090-2 [pii]
AID - 10.1016/j.tem.2012.05.010 [doi]
PST - ppublish
SO  - Trends Endocrinol Metab. 2012 Oct;23(10):498-500. doi: 10.1016/j.tem.2012.05.010.
      Epub 2012 Jun 27.


PMID- 22742750
OWN - NLM
STAT- MEDLINE
DCOM- 20121022
LR  - 20120629
IS  - 1878-0369 (Electronic)
IS  - 0001-2092 (Linking)
VI  - 96
IP  - 1
DP  - 2012 Jul
TI  - Case study: family presence in the OR for donation after cardiac death.
PG  - 34-44
LID - 10.1016/j.aorn.2012.04.017 [doi]
AB  - Organ donation after cardiac death is an ethical and acceptable practice of
      providing organs for transplantation. Organ recovery, the removal of life
      support, and patient death occur in the OR, and, because family members are not
      present, some feel that they have abandoned their loved one. This article reports
      a case study of a young woman brought to a level I trauma center with
      nonsurvivable injuries from a motor vehicle accident. When clinical examinations 
      revealed no hope of recovery, the family agreed to organ donation if the mother
      could be present in the OR when life support was terminated. Family member
      presence during organ donation may provide a sense that some good has come of a
      personal tragedy. Although family requests may be unsettling, advocating for the 
      patient and family is part of the nurse's role.
CI  - Copyright (c) 2012 AORN, Inc. Published by Elsevier Inc. All rights reserved.
FAU - Reed, Charles C
AU  - Reed CC
AD  - University Health System, San Antonio, TX, USA.
FAU - Gerhardt, Susan D
AU  - Gerhardt SD
FAU - Shaver, Karen
AU  - Shaver K
FAU - Koebcke, Marsha
AU  - Koebcke M
FAU - Mullins, Darla
AU  - Mullins D
LA  - eng
PT  - Journal Article
PL  - United States
TA  - AORN J
JT  - AORN journal
JID - 0372403
SB  - IM
MH  - Adult
MH  - *Death
MH  - Family/*psychology
MH  - Female
MH  - Humans
MH  - Mothers/*psychology
MH  - *Operating Rooms
MH  - *Tissue Donors
EDAT- 2012/06/30 06:00
MHDA- 2012/10/23 06:00
CRDT- 2012/06/30 06:00
PHST- 2011/06/17 00:00 [received]
PHST- 2012/03/29 00:00 [revised]
PHST- 2012/04/20 00:00 [accepted]
PHST- 2012/06/30 06:00 [entrez]
PHST- 2012/06/30 06:00 [pubmed]
PHST- 2012/10/23 06:00 [medline]
AID - S0001-2092(12)00413-9 [pii]
AID - 10.1016/j.aorn.2012.04.017 [doi]
PST - ppublish
SO  - AORN J. 2012 Jul;96(1):34-44. doi: 10.1016/j.aorn.2012.04.017.


PMID- 22742710
OWN - NLM
STAT- MEDLINE
DCOM- 20130104
LR  - 20211021
IS  - 1472-6920 (Electronic)
IS  - 1472-6920 (Linking)
VI  - 12
DP  - 2012 Jun 28
TI  - Reflections of students graduating from a transforming medical curriculum in
      South Africa: a qualitative study.
PG  - 49
AB  - BACKGROUND: The six year medical programme at the University of the Witwatersrand
      admits students into the programme through two routes--school entrants and
      graduate entrants. Graduates join the school entrants in the third year of study 
      in a transformed curriculum called the Graduate Entry Medical Programme (GEMP).
      In years I and 2 of the GEMP, the curriculum is structured into system based
      blocks. Problem-based learning, using a three session format, is applied in these
      two years. The curriculum adopts a biopsychosocial approach to health care, which
      is implemented through spiral teaching and learning in four main themes--basic
      and clinical sciences, patient-doctor, community--doctor and personal and
      professional development. In 2010 this programme produced its fifth cohort of
      graduates. METHODS: We undertook a qualitative, descriptive and contextual study 
      to explore the graduating students' perceptions of the programme. Interviews were
      conducted with a total of 35 participants who volunteered to participate in the
      study. The majority of the participants interviewed participated in focus group
      discussions. The interviews were transcribed verbatim and analysed thematically, 
      using Tesch's eight steps. Ethics approval for the study was obtained from the
      Human Research Ethics Committee of the University of the Witwatersrand.
      Participants provided written consent to participate in the interviews and for
      the interviews to be audio-taped. RESULTS: Six themes were identified. These
      were: two separate programmes, problem-based learning and Garmins(R) (navigation 
      system), see patients for real, being seen as doctors, assessment: of mice and
      MCQ's, a cry for support and personal growth and pride. Participants were vocal
      in their reflections of experiences encountered during the programme and made
      several insightful suggestions for curriculum transformation. The findings
      suggest that graduates are exiting the programme confident and ready to begin
      their internships. CONCLUSIONS: The findings of this study have identified a
      number of areas which need attention in the curriculum. Specifically attention
      needs to be given to ensuring that assessment is standardized; student support
      structures and appropriate levels of teaching. The study demonstrated the value
      of qualitative methods in obtaining students' perceptions of a curriculum.
FAU - Green-Thompson, Lionel Patrick
AU  - Green-Thompson LP
AD  - Centre for Health Science Education, Faculty of Health Sciences, University of
      the Witwatersrand, 7 York Rd, Parktown, Johannesburg 2193, South Africa.
FAU - McInerney, Patricia
AU  - McInerney P
FAU - Manning, Dianne Mary
AU  - Manning DM
FAU - Mapukata-Sondzaba, Ntsiki
AU  - Mapukata-Sondzaba N
FAU - Chipamaunga, Shalote
AU  - Chipamaunga S
FAU - Maswanganyi, Tlangelani
AU  - Maswanganyi T
LA  - eng
PT  - Journal Article
DEP - 20120628
PL  - England
TA  - BMC Med Educ
JT  - BMC medical education
JID - 101088679
SB  - IM
MH  - Attitude of Health Personnel
MH  - Curriculum
MH  - Education, Medical/*methods/standards
MH  - Female
MH  - Focus Groups
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Problem-Based Learning
MH  - Program Evaluation
MH  - South Africa
MH  - Students, Medical/psychology/statistics & numerical data
PMC - PMC3460748
EDAT- 2012/06/30 06:00
MHDA- 2013/01/05 06:00
CRDT- 2012/06/30 06:00
PHST- 2011/10/28 00:00 [received]
PHST- 2012/06/24 00:00 [accepted]
PHST- 2012/06/30 06:00 [entrez]
PHST- 2012/06/30 06:00 [pubmed]
PHST- 2013/01/05 06:00 [medline]
AID - 1472-6920-12-49 [pii]
AID - 10.1186/1472-6920-12-49 [doi]
PST - epublish
SO  - BMC Med Educ. 2012 Jun 28;12:49. doi: 10.1186/1472-6920-12-49.


PMID- 22742595
OWN - NLM
STAT- MEDLINE
DCOM- 20130128
LR  - 20151119
IS  - 1557-9034 (Electronic)
IS  - 1092-6429 (Linking)
VI  - 22
IP  - 7
DP  - 2012 Sep
TI  - IPEG survey on live case demonstrations in pediatric surgery.
PG  - 705-9
LID - 10.1089/lap.2012.0031 [doi]
AB  - BACKGROUND: Live case demonstrations (LCDs) represent a common educational method
      throughout most surgical specialties. Concern has been raised about ethics and
      patient safety. The surgeon's elevated stress level, the need to comply with the 
      meetings' time schedules, unfamiliar surgical equipment, and questionable
      indications resulted in prohibition of LCD in some surgical societies. We aimed
      to investigate the opinion of International Pediatric Endosurgery Group (IPEG)
      members on LCD. MATERIALS AND METHODS: An online-based survey in 2010-2011
      requested all IPEG members to complete a questionnaire including data on personal
      background and statements on LCD. Participants had to indicate agreement with
      statements on a scale from 1 (do not agree) to 5 (fully agree). RESULTS:
      Sixty-one surgeons and 148 attendees completed the questionnaire. Eighty-three
      percent of surgeons indicated elevated stress levels during LCD. Surgeons
      (3+/-1.2) and attendees (3+/-1.4) agreed that LCD may be harmful. Surgeons
      (2+/-1.2) and attendees (2+/-1.3) disagreed that LCD may be beneficial for
      patients. However, LCD was rated as educationally essential by surgeons (3+/-1.3)
      and attendees (3+/-1.3). Surgeons agreed (3+/-1.2) that educational benefits of
      LCD outweigh disadvantages for patients; attendees did not agree (2+/-1.3).
      Surgeons (4+/-1.4) and attendees (3+/-1.4) agreed that LCD should continue.
      Nevertheless, 36% of surgeons and 52% of attendees would not consent for LCD in
      their own child. CONCLUSIONS: LCD is regarded an essential part of surgical
      education by IPEG members. However, it represents a controversial topic. The
      majority of IPEG members appear willing to continue LCD. If IPEG decides to go on
      with LCD, attention has to be drawn to patient safety and ethical considerations.
FAU - Dingemann, Jens
AU  - Dingemann J
AD  - Research Committee, International Pediatric Endosurgery Group (IPEG), Los
      Angeles, CA, USA. dingemann.jens@mh-hannover.de
FAU - Laje, Pablo
AU  - Laje P
FAU - St Peter, Shawn D
AU  - St Peter SD
FAU - Ure, Benno M
AU  - Ure BM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120628
PL  - United States
TA  - J Laparoendosc Adv Surg Tech A
JT  - Journal of laparoendoscopic & advanced surgical techniques. Part A
JID - 9706293
SB  - IM
MH  - Education, Medical/*methods
MH  - Endoscopy/*education
MH  - Pediatrics/*education
MH  - Specialties, Surgical/*education
MH  - Surveys and Questionnaires
EDAT- 2012/06/30 06:00
MHDA- 2013/01/29 06:00
CRDT- 2012/06/30 06:00
PHST- 2012/06/30 06:00 [entrez]
PHST- 2012/06/30 06:00 [pubmed]
PHST- 2013/01/29 06:00 [medline]
AID - 10.1089/lap.2012.0031 [doi]
PST - ppublish
SO  - J Laparoendosc Adv Surg Tech A. 2012 Sep;22(7):705-9. doi: 10.1089/lap.2012.0031.
      Epub 2012 Jun 28.


PMID- 22741503
OWN - NLM
STAT- MEDLINE
DCOM- 20120731
LR  - 20180620
IS  - 0241-6972 (Print)
IS  - 0241-6972 (Linking)
IP  - 280
DP  - 2012 May-Jun
TI  - [Architecture and movement].
PG  - 31-4
AB  - Leading an architectural project means accompanying the movement which it induces
      within the teams. Between questioning, uncertainty and fear, the organisational
      changes inherent to the new facility must be subject to constructive and ongoing 
      exchanges. Ethics, safety and training are revised and the unit projects are
      sometimes modified.
FAU - Rivallan, Armel
AU  - Rivallan A
AD  - Cadre superieur de sante, Centre hospitalier de Quimperle.
      armel.rivallan@orange.fr
LA  - fre
PT  - Journal Article
TT  - Architecture et mouvement.
PL  - France
TA  - Soins Psychiatr
JT  - Soins. Psychiatrie
JID - 8203334
MH  - *Architecture
MH  - *Cooperative Behavior
MH  - Day Care, Medical/organization & administration
MH  - Hospital Design and Construction/*methods
MH  - Hospitals, Psychiatric/*organization & administration
MH  - Humans
MH  - *Interdisciplinary Communication
MH  - Mental Disorders/*nursing
MH  - Nursing, Team/organization & administration
MH  - Psychiatric Nursing/*organization & administration
MH  - Security Measures/organization & administration
MH  - Social Environment
EDAT- 2012/06/30 06:00
MHDA- 2012/08/01 06:00
CRDT- 2012/06/30 06:00
PHST- 2012/06/30 06:00 [entrez]
PHST- 2012/06/30 06:00 [pubmed]
PHST- 2012/08/01 06:00 [medline]
AID - S0241-6972(12)00052-7 [pii]
PST - ppublish
SO  - Soins Psychiatr. 2012 May-Jun;(280):31-4.


PMID- 22741473
OWN - NLM
STAT- MEDLINE
DCOM- 20120828
LR  - 20120629
IS  - 1001-5302 (Print)
IS  - 1001-5302 (Linking)
VI  - 37
IP  - 1
DP  - 2012 Jan
TI  - [Quality assessment of randomized controlled trials on wenxin granule for
      treatment of atrial fibrillation].
PG  - 109-14
AB  - OBJECTIVE: To investigate the statement on randomized controlled trials on Wenxin
      granule for treatment of atrial fibrillation and to judge whether those trials
      could offer high quality evidence or not, thus improve design level and quality. 
      METHOD: RCTs were searched from home and abroad about atrial fibrillation treated
      with Wenxin granule, which reported before October, 2010. Jadad scale and CONSORT
      statement were used. RESULT: There were 66 RCTs retrieved that met inclusion
      criteria. Using Jadad rating scale, only 2 literatures gain score 4 and 1
      literature gains score 3, 54 literatures gain score 2, 7 literatures gain score
      1, 2 literatures gain score 0. Only 2 literatures described random number table
      as the method of grouping. None of the RCTs was reported the allocation
      concealment. Only 1 literature was used blinding. Fifty-nine literatures were
      mentioned the lost to follow-up conditions. According to the CONSORT standards,
      only six literatures (9.1%) mentioned the method of generating the random
      sequence. Four literatures (6.1%) were quasi-random. Nineteen literatures (28.8%)
      had inclusion criteria. Six literatures (9.1%) had the follow-up record. Fifty
      one literatures (77.3%) described the adverse events. None had the estimation of 
      the sample size, intention-to-treat analysis and stratified analysis. None had
      the ethical approval or informed consent. CONCLUSION: The quality of clinical
      trials of Wenxin granule in treating atrial fibrillation needs to be improved.
FAU - Liu, Weimin
AU  - Liu W
AD  - Institute of Basic Research In Clinical Medicine, China Academy of Chinese
      Medical Sciences, Beijing 100700, China. liuweimin68@yahoo.com.cn
FAU - Jiang, Rui
AU  - Jiang R
FAU - Ding, Shasha
AU  - Ding S
FAU - Fu, Wei
AU  - Fu W
FAU - Wang, Shuqin
AU  - Wang S
FAU - Li, Xue
AU  - Li X
FAU - Kang, Jing
AU  - Kang J
FAU - Wu, Dongning
AU  - Wu D
FAU - Liu, Bo
AU  - Liu B
FAU - Mao, Wenchao
AU  - Mao W
FAU - He, Liyun
AU  - He L
FAU - Liu, Baoyan
AU  - Liu B
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Zhong Yao Za Zhi
JT  - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese
      materia medica
JID - 8913656
RN  - 0 (Drugs, Chinese Herbal)
SB  - IM
MH  - Atrial Fibrillation/*drug therapy
MH  - Drugs, Chinese Herbal/*therapeutic use
MH  - Humans
MH  - Randomized Controlled Trials as Topic
EDAT- 2012/06/30 06:00
MHDA- 2012/08/29 06:00
CRDT- 2012/06/30 06:00
PHST- 2012/06/30 06:00 [entrez]
PHST- 2012/06/30 06:00 [pubmed]
PHST- 2012/08/29 06:00 [medline]
PST - ppublish
SO  - Zhongguo Zhong Yao Za Zhi. 2012 Jan;37(1):109-14.


PMID- 22741313
OWN - NLM
STAT- MEDLINE
DCOM- 20120814
LR  - 20151119
IS  - 1268-6034 (Print)
IS  - 1268-6034 (Linking)
IP  - 95
DP  - 2012 May-Jun
TI  - [An individualized life project: from theory to practice].
PG  - 12-3
AB  - A life project defines the conditions of personalised treatment and support. The 
      main objective is to consider the human being from an ethical perspective, to
      respect an individual's dignity and rights despite the dependency, as well as to 
      provide a decent quality of life for the user. It mobilises all the caregivers,
      refocusing their actions on the resident, in accordance with his or her wishes
      and those of the family.
FAU - Lombard, Marie
AU  - Lombard M
AD  - Long sejour Les Vergers de la Chartreuse, Centre hospitalier la Chartreuse,
      Dijon. marie.lombard@chs-chartreuse.fr
FAU - Lechenet, Martine
AU  - Lechenet M
FAU - Dupuis, Justine
AU  - Dupuis J
FAU - Milleret, Marianne
AU  - Milleret M
FAU - Weyrich, Alain
AU  - Weyrich A
FAU - Jasmin, Jaon
AU  - Jasmin J
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Le projet de vie individualise: de la theorie a la pratique.
PL  - France
TA  - Soins Gerontol
JT  - Soins. Gerontologie
JID - 9616322
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - France
MH  - Human Rights
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nursing Homes/*organization & administration
MH  - *Personhood
MH  - *Precision Medicine
MH  - *Quality of Life
EDAT- 2012/06/30 06:00
MHDA- 2012/08/15 06:00
CRDT- 2012/06/30 06:00
PHST- 2012/06/30 06:00 [entrez]
PHST- 2012/06/30 06:00 [pubmed]
PHST- 2012/08/15 06:00 [medline]
PST - ppublish
SO  - Soins Gerontol. 2012 May-Jun;(95):12-3.


PMID- 22740357
OWN - NLM
STAT- MEDLINE
DCOM- 20130717
LR  - 20211021
IS  - 1473-6810 (Electronic)
IS  - 1356-5524 (Linking)
VI  - 18
IP  - 1
DP  - 2013 Feb
TI  - Principles for high-quality, high-value testing.
PG  - 5-10
LID - 10.1136/eb-2012-100645 [doi]
AB  - A survey of doctors working in two large NHS hospitals identified over 120
      laboratory tests, imaging investigations and investigational procedures that they
      considered not to be overused. A common suggestion in this survey was that more
      training was required. And, this prompted the development of a list of core
      principles for high-quality, high-value testing. The list can be used as a
      framework for training and as a reference source. The core principles are: (1)
      Base testing practices on the best available evidence. (2) Apply the evidence on 
      test performance with careful judgement. (3) Test efficiently. (4) Consider the
      value (and affordability) of a test before requesting it. (5) Be aware of the
      downsides and drivers of overdiagnosis. (6) Confront uncertainties. (7) Be
      patient-centred in your approach. (8) Consider ethical issues. (9) Be aware of
      normal cognitive limitations and biases when testing. (10) Follow the 'knowledge 
      journey' when teaching and learning these core principles.
FAU - Power, Michael
AU  - Power M
AD  - Pharmacy Department, Newcastle upon Tyne Hospitals NHS Foundation Trust,
      Newcastle upon Tyne, UK. Michael.Power@NUTH.NHS.UK
FAU - Fell, Greg
AU  - Fell G
FAU - Wright, Michael
AU  - Wright M
LA  - eng
PT  - Journal Article
DEP - 20120627
PL  - England
TA  - Evid Based Med
JT  - Evidence-based medicine
JID - 9608386
SB  - IM
MH  - Cost-Benefit Analysis
MH  - Diagnostic Tests, Routine/economics/*standards
MH  - Evidence-Based Medicine/*standards
MH  - Humans
MH  - Predictive Value of Tests
MH  - Quality of Health Care/standards
MH  - Sensitivity and Specificity
MH  - Uncertainty
PMC - PMC3585491
EDAT- 2012/06/29 06:00
MHDA- 2013/07/19 06:00
CRDT- 2012/06/29 06:00
PHST- 2012/06/29 06:00 [entrez]
PHST- 2012/06/29 06:00 [pubmed]
PHST- 2013/07/19 06:00 [medline]
AID - eb-2012-100645 [pii]
AID - 10.1136/eb-2012-100645 [doi]
PST - ppublish
SO  - Evid Based Med. 2013 Feb;18(1):5-10. doi: 10.1136/eb-2012-100645. Epub 2012 Jun
      27.


PMID- 22740224
OWN - NLM
STAT- MEDLINE
DCOM- 20120731
LR  - 20130206
IS  - 1107-0625 (Print)
IS  - 1107-0625 (Linking)
VI  - 17
IP  - 2
DP  - 2012 Apr-Jun
TI  - Science ethics education part II: changes in attitude toward scientific fraud
      among medical researchers after a short course in science ethics.
PG  - 391-5
AB  - PURPOSE: To determine the impact of the short science ethics courses on the
      knowledge of basic principles of responsible conduct of research (RCR), and on
      the attitude toward scientific fraud among young biomedical researchers. METHODS:
      A total of 361 attendees of the course on science ethics answered a specially
      designed anonymous multiple- choice questionnaire before and after a one-day
      course in science ethics. The educational course consisted of 10 lectures: 1)
      Good scientific practice - basic principles; 2) Publication ethics; 3) Scientific
      fraud - fabrication, falsification, plagiarism; 4) Conflict of interests; 5)
      Underpublishing; 6) Mentorship; 7) Authorship; 8) Coauthorship; 9) False
      authorship; 10) Good scientific practice - ethical codex of science. RESULTS: In 
      comparison to their answers before the course, a significantly higher (p<0.001)
      number of students qualified their knowledge of science ethics as sufficient
      after the course was completed. That the wrongdoers deserve severe punishment for
      all types of scientific fraud, including false authorship, thought significantly 
      (p<0.001) more attendees than before the course, while notably fewer attendees
      (p<0.001) would give or accept undeserved authorship CONCLUSION: Even a short
      course in science ethics had a great impact on the attendees, enlarging their
      knowledge of responsible conduct of research and changing their previous,
      somewhat opportunistic, behavior regarding the reluctance to react publicly and
      punish the wrongdoers.
FAU - Vuckovic-Dekic, L
AU  - Vuckovic-Dekic L
AD  - Institute for Oncology and Radiology of Serbia, Belgrade, Serbia.
      ljiljanavd@gmail.com
FAU - Gavrilovic, D
AU  - Gavrilovic D
FAU - Kezic, I
AU  - Kezic I
FAU - Bogdanovic, G
AU  - Bogdanovic G
FAU - Brkic, S
AU  - Brkic S
LA  - eng
PT  - Journal Article
PL  - Cyprus
TA  - J BUON
JT  - Journal of B.U.ON. : official journal of the Balkan Union of Oncology
JID - 100883428
SB  - IM
CIN - J BUON. 2012 Oct-Dec;17(4):804; author's reply p. 804. PMID: 23387093
MH  - *Attitude
MH  - Authorship
MH  - Biomedical Research/*ethics
MH  - *Ethics, Research
MH  - Guidelines as Topic
MH  - Humans
MH  - Morals
MH  - Plagiarism
MH  - Publishing/*ethics
MH  - *Research Personnel
MH  - Scientific Misconduct/*ethics/*psychology
MH  - Students
MH  - Truth Disclosure
MH  - Whistleblowing
EDAT- 2012/06/29 06:00
MHDA- 2012/08/01 06:00
CRDT- 2012/06/29 06:00
PHST- 2012/06/29 06:00 [entrez]
PHST- 2012/06/29 06:00 [pubmed]
PHST- 2012/08/01 06:00 [medline]
PST - ppublish
SO  - J BUON. 2012 Apr-Jun;17(2):391-5.


PMID- 22740222
OWN - NLM
STAT- MEDLINE
DCOM- 20120731
LR  - 20151119
IS  - 1107-0625 (Print)
IS  - 1107-0625 (Linking)
VI  - 17
IP  - 2
DP  - 2012 Apr-Jun
TI  - Ethical and legal aspects of oncogenomics.
PG  - 383-8
AB  - The discovery of the genes and cellular pathways that play fundamental roles in
      several diseases, and the understanding of many diseases at a molecular level due
      to the advances in the field of genomics, have revolutionized the diagnosis,
      therapy and prevention of human diseases. Application of genetic testing in
      numerous medical fields, including pharmacogenomics and oncogenomics, raised
      numerous ethical questions and introduced legal instruments that are aimed at
      ensuring the appropriate protection of human research participants. For the
      effective development of human genomics and translation of novel, validated
      biomarkers into potentially useful clinical applications in personalized
      medicine, there is a need for clear ethical standards and principles in all
      phases of clinical research.
FAU - Stankov, K
AU  - Stankov K
AD  - University of Novi Sad, Novi Sad, Serbia. stankov_karmen@uns.ac.rs
FAU - Draskovic, D
AU  - Draskovic D
FAU - Mikov, M
AU  - Mikov M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Cyprus
TA  - J BUON
JT  - Journal of B.U.ON. : official journal of the Balkan Union of Oncology
JID - 100883428
SB  - IM
MH  - Biomedical Research
MH  - Genetic Testing/*ethics/*legislation & jurisprudence
MH  - *Genomics
MH  - Humans
MH  - Neoplasms/diagnosis/*genetics/therapy
MH  - *Oncogenes
MH  - *Precision Medicine
EDAT- 2012/06/29 06:00
MHDA- 2012/08/01 06:00
CRDT- 2012/06/29 06:00
PHST- 2012/06/29 06:00 [entrez]
PHST- 2012/06/29 06:00 [pubmed]
PHST- 2012/08/01 06:00 [medline]
PST - ppublish
SO  - J BUON. 2012 Apr-Jun;17(2):383-8.


PMID- 22740035
OWN - NLM
STAT- MEDLINE
DCOM- 20140122
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 3
DP  - 2013 Sep
TI  - Research integrity and everyday practice of science.
PG  - 685-701
LID - 10.1007/s11948-012-9376-5 [doi]
AB  - Science traditionally is taught as a linear process based on logic and carried
      out by objective researchers following the scientific method. Practice of science
      is a far more nuanced enterprise, one in which intuition and passion become just 
      as important as objectivity and logic. Whether the activity is committing to
      study a particular research problem, drawing conclusions about a hypothesis under
      investigation, choosing whether to count results as data or experimental noise,
      or deciding what information to present in a research paper, ethical challenges
      inevitably will arise because of the ambiguities inherent in practice. Unless
      these ambiguities are acknowledged and their sources understood explicitly,
      responsible conduct of science education will not adequately prepare the
      individuals receiving the training for the kinds of decisions essential to
      research integrity that they will have to make as scientists.
FAU - Grinnell, Frederick
AU  - Grinnell F
AD  - Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX 75390,
      USA. frederick.grinnell@utsouthwestern.edu
LA  - eng
PT  - Journal Article
DEP - 20120628
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Decision Making/*ethics
MH  - Ethics, Research/*education
MH  - Humans
MH  - Research Personnel
MH  - Science/*education/ethics
MH  - Uncertainty
EDAT- 2012/06/29 06:00
MHDA- 2014/01/23 06:00
CRDT- 2012/06/29 06:00
PHST- 2012/04/21 00:00 [received]
PHST- 2012/06/14 00:00 [accepted]
PHST- 2012/06/29 06:00 [entrez]
PHST- 2012/06/29 06:00 [pubmed]
PHST- 2014/01/23 06:00 [medline]
AID - 10.1007/s11948-012-9376-5 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Sep;19(3):685-701. doi: 10.1007/s11948-012-9376-5. Epub 2012
      Jun 28.


PMID- 22739759
OWN - NLM
STAT- MEDLINE
DCOM- 20130703
LR  - 20211021
IS  - 1573-3599 (Electronic)
IS  - 1059-7700 (Linking)
VI  - 22
IP  - 1
DP  - 2013 Feb
TI  - Genetic counseling supervisor competencies: results of a Delphi study.
PG  - 39-57
LID - 10.1007/s10897-012-9512-z [doi]
AB  - Clinical supervision is a critical component of genetic counseling student
      preparation, yet empirically-determined competencies for genetic counseling
      supervisors are lacking. In this study a modified, two-round Delphi method was
      used to gain consensus about important genetic counseling supervisor knowledge,
      characteristics, and skills. Program directors and assistant directors of
      American Board of Genetic Counseling accredited genetic counseling programs in
      North America (N = 33) were invited to participate and to recruit three
      experienced supervisors. Seventy-four individuals completed Round 1 and, of
      these, 61 completed Round 2. Approximately two-thirds were clinical supervisors
      from prenatal, pediatrics, cancer, and adult clinics; one-third were program
      directors. Participants rated the importance for genetic counseling supervisors
      of 158 items derived from supervision literature in allied health professions.
      They rated 142 items (89.9 %) as highly important. Content analysis of these
      items yielded six supervisor competency domains: Personal traits and
      characteristics; relationship building and maintenance; student evaluation;
      student centered supervision; guidance and monitoring of patient care; and
      ethical and legal aspects of supervision. The results provide a basis for
      training genetic counseling supervisors and for further research to refine and
      validate supervisor competencies.
FAU - Eubanks Higgins, Sonja
AU  - Eubanks Higgins S
AD  - Genetic Counseling Program, The University of North Carolina at Greensboro, 119
      McIver St, Greensboro, NC, USA. sonjaeubanks@yahoo.com
FAU - Veach, Patricia McCarthy
AU  - Veach PM
FAU - MacFarlane, Ian M
AU  - MacFarlane IM
FAU - Borders, L DiAnne
AU  - Borders LD
FAU - LeRoy, Bonnie
AU  - LeRoy B
FAU - Callanan, Nancy
AU  - Callanan N
LA  - eng
PT  - Journal Article
DEP - 20120628
PL  - United States
TA  - J Genet Couns
JT  - Journal of genetic counseling
JID - 9206865
SB  - IM
MH  - Delphi Technique
MH  - Female
MH  - *Genetic Counseling
MH  - Humans
MH  - Male
MH  - *Professional Competence
EDAT- 2012/06/29 06:00
MHDA- 2013/07/05 06:00
CRDT- 2012/06/29 06:00
PHST- 2012/03/22 00:00 [received]
PHST- 2012/05/29 00:00 [accepted]
PHST- 2012/06/29 06:00 [entrez]
PHST- 2012/06/29 06:00 [pubmed]
PHST- 2013/07/05 06:00 [medline]
AID - 10.1007/s10897-012-9512-z [doi]
PST - ppublish
SO  - J Genet Couns. 2013 Feb;22(1):39-57. doi: 10.1007/s10897-012-9512-z. Epub 2012
      Jun 28.


PMID- 22739341
OWN - NLM
STAT- MEDLINE
DCOM- 20130920
LR  - 20211021
IS  - 1476-5438 (Electronic)
IS  - 1018-4813 (Linking)
VI  - 21
IP  - 3
DP  - 2013 Mar
TI  - To tell or not to tell? A systematic review of ethical reflections on incidental 
      findings arising in genetics contexts.
PG  - 248-55
LID - 10.1038/ejhg.2012.130 [doi]
AB  - Any test that produces visual images or digital or genetic sequences will tend to
      produce incidental findings because more will be visible than what was originally
      sought. We conducted a systematic review of the ethical reasons presented in the 
      literature for and against the disclosure of incidental findings arising in
      clinical and research genetics contexts. A search of electronic databases
      resulted in 13 articles included for systematic review. Articles presented
      reasons for and against disclosure, and reasons for proceeding with caution when 
      making decisions about disclosure. One major recommendation of the reviewed
      articles is in favor of qualified disclosure: incidental findings with confirmed 
      clinical utility where there is the possibility of treatment or prevention should
      be disclosed, with exceptions. A second type of recommendation is that disclosure
      should proceed with caution, especially in the context of new genetic
      technologies and genetic testing involving minors. It is also recommended that
      the number of possible incidental findings be limited even before genetic testing
      is carried out. Such a policy, which we advocate, would show preference for
      non-disclosure.
FAU - Christenhusz, Gabrielle M
AU  - Christenhusz GM
AD  - Centre for Biomedical Ethics and Law, Catholic University of Leuven, Leuven,
      Belgium. gabrielle.christenhusz@med.kuleuven.be
FAU - Devriendt, Koenraad
AU  - Devriendt K
FAU - Dierickx, Kris
AU  - Dierickx K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20120627
PL  - England
TA  - Eur J Hum Genet
JT  - European journal of human genetics : EJHG
JID - 9302235
SB  - IM
MH  - Disclosure/*ethics
MH  - Genetic Research/*ethics
MH  - Genetic Testing/*ethics
MH  - Humans
MH  - *Incidental Findings
PMC - PMC3573190
EDAT- 2012/06/29 06:00
MHDA- 2013/09/21 06:00
CRDT- 2012/06/29 06:00
PHST- 2012/06/29 06:00 [entrez]
PHST- 2012/06/29 06:00 [pubmed]
PHST- 2013/09/21 06:00 [medline]
AID - ejhg2012130 [pii]
AID - 10.1038/ejhg.2012.130 [doi]
PST - ppublish
SO  - Eur J Hum Genet. 2013 Mar;21(3):248-55. doi: 10.1038/ejhg.2012.130. Epub 2012 Jun
      27.


PMID- 22739260
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20220309
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 75
IP  - 7
DP  - 2012 Oct
TI  - Social welfare and the Affordable Care Act: is it ever optimal to set aside
      comparative cost?
PG  - 1156-62
LID - 10.1016/j.socscimed.2012.05.019 [doi]
AB  - The creation of the Patient-Centered Outcomes Research Institute (PCORI) under
      the Affordable Care Act has set comparative effectiveness research (CER) at
      centre stage of US health care reform. Comparative cost analysis has remained
      marginalised and it now appears unlikely that the PCORI will require comparative 
      cost data to be collected as an essential component of CER. In this paper, we
      review the literature to identify ethical and distributional objectives that
      might motivate calls to set priorities without regard to comparative cost. We
      then present argument and evidence to consider whether there is any plausible set
      of objectives and constraints against which priorities can be set without
      reference to comparative cost. We conclude that - to set aside comparative cost
      even after accounting for ethical and distributional constraints - would be truly
      to act as if money is no object.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Mortimer, Duncan
AU  - Mortimer D
AD  - Centre for Health Economics, Faculty of Business & Economics, Monash University, 
      Building 75, Melbourne, Victoria 3800, Australia.
      duncan.mortimer@buseco.monash.edu.au
FAU - Peacock, Stuart
AU  - Peacock S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120616
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - *Comparative Effectiveness Research
MH  - Cost-Benefit Analysis
MH  - Humans
MH  - Patient Protection and Affordable Care Act/*economics
MH  - Social Welfare/*economics
MH  - United States
EDAT- 2012/06/29 06:00
MHDA- 2012/11/14 06:00
CRDT- 2012/06/29 06:00
PHST- 2011/10/26 00:00 [received]
PHST- 2012/04/30 00:00 [revised]
PHST- 2012/05/16 00:00 [accepted]
PHST- 2012/06/29 06:00 [entrez]
PHST- 2012/06/29 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
AID - S0277-9536(12)00447-9 [pii]
AID - 10.1016/j.socscimed.2012.05.019 [doi]
PST - ppublish
SO  - Soc Sci Med. 2012 Oct;75(7):1156-62. doi: 10.1016/j.socscimed.2012.05.019. Epub
      2012 Jun 16.


PMID- 22738622
OWN - NLM
STAT- MEDLINE
DCOM- 20120918
LR  - 20151119
IS  - 1839-4345 (Electronic)
IS  - 1034-7674 (Linking)
VI  - 23
IP  - 5-6
DP  - 2012 May-Jun
TI  - Ethical issues in obesity interventions for populations.
PG  - 116-9
LID - 10.1071/NB12062 [doi]
AB  - Beyond the usual technical and evidentiary considerations, there are ethical
      questions that we must consider in the justification of our obesity interventions
      in the name of expected population health gains. These relate to the types of
      health identities that are permitted in society, the possible unintended
      consequences of preferencing certain health identities over others, and the
      manner in which public health policies and interventions are justified. The
      prevalence of overweight and obesity in Australia highlights some of the areas of
      uncertainty and identifies some important ethical questions that arise as a
      result of this uncertainty. I propose that the Australian obesity prevention
      strategy could be evaluated using the Nuffield Council on Bioethics stewardship
      model of public health to assess whether any current approaches exceed
      recommended intervention constraints or limits. My aim is to prompt further
      debate on this topic.
FAU - Fry, Craig L
AU  - Fry CL
AD  - Health Ethics and Policy, Murdoch Childrens Research Institute.
      craig.fry@mcri.edu.au
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - N S W Public Health Bull
JT  - New South Wales public health bulletin
JID - 9712270
SB  - IM
MH  - Australia/epidemiology
MH  - Bioethics
MH  - Government Programs/ethics
MH  - *Health Policy
MH  - Humans
MH  - *Obesity/epidemiology/prevention & control
MH  - Overweight/epidemiology/prevention & control
MH  - Public Health/*ethics
EDAT- 2012/06/29 06:00
MHDA- 2012/09/19 06:00
CRDT- 2012/06/29 06:00
PHST- 2012/06/29 06:00 [entrez]
PHST- 2012/06/29 06:00 [pubmed]
PHST- 2012/09/19 06:00 [medline]
AID - NB12062 [pii]
AID - 10.1071/NB12062 [doi]
PST - ppublish
SO  - N S W Public Health Bull. 2012 May-Jun;23(5-6):116-9. doi: 10.1071/NB12062.


PMID- 22738621
OWN - NLM
STAT- MEDLINE
DCOM- 20120918
LR  - 20141216
IS  - 1839-4345 (Electronic)
IS  - 1034-7674 (Linking)
VI  - 23
IP  - 5-6
DP  - 2012 May-Jun
TI  - An ethical framework for public health immunisation programs.
PG  - 111-5
LID - 10.1071/NB11045 [doi]
AB  - This paper presents seven ethical principles associated with the implementation
      of immunisation programs. For a public health immunisation program to be
      ethically justifiable, its principles and operation should be based on sound
      ethical values: the program should benefit the individual and the community;
      targeted diseases should be sufficiently severe and frequent to justify the risks
      and expense of the program, and vulnerable groups within the population should be
      targeted. The principles also deal with the obligation to monitor for adverse
      events and for disease incidence to ensure safety and effectiveness. When
      immunisations are voluntary, vaccine recipients or their parents or carers should
      be given sufficient information to make autonomous, informed decisions and
      incentives to participate in public health immunisation programs should not be
      coercive. Public health immunisation programs depend on mutual trust, which may
      be threatened by circumstances such as excessive media publicity about adverse
      events associated with vaccines.
FAU - Isaacs, David
AU  - Isaacs D
AD  - Department of Infectious Diseases, Children's Hospital at Westmead.
      david.isaacs@health.nsw.gov.au
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - N S W Public Health Bull
JT  - New South Wales public health bulletin
JID - 9712270
RN  - 0 (Vaccines)
SB  - IM
MH  - Child
MH  - Coercion
MH  - Cost-Benefit Analysis
MH  - Decision Making
MH  - Healthcare Disparities
MH  - Humans
MH  - Immunization Programs/*ethics
MH  - Informed Consent
MH  - Parents
MH  - Proxy
MH  - Public Health/*ethics
MH  - Risk
MH  - Social Justice
MH  - Trust
MH  - *Vaccines/administration & dosage/adverse effects
MH  - Vulnerable Populations
EDAT- 2012/06/29 06:00
MHDA- 2012/09/19 06:00
CRDT- 2012/06/29 06:00
PHST- 2012/06/29 06:00 [entrez]
PHST- 2012/06/29 06:00 [pubmed]
PHST- 2012/09/19 06:00 [medline]
AID - NB11045 [pii]
AID - 10.1071/NB11045 [doi]
PST - ppublish
SO  - N S W Public Health Bull. 2012 May-Jun;23(5-6):111-5. doi: 10.1071/NB11045.


PMID- 22738620
OWN - NLM
STAT- MEDLINE
DCOM- 20120918
LR  - 20141216
IS  - 1839-4345 (Electronic)
IS  - 1034-7674 (Linking)
VI  - 23
IP  - 5-6
DP  - 2012 May-Jun
TI  - Evidence and ethics in public health: the experience of SARS in Canada.
PG  - 108-10
LID - 10.1071/NB11044 [doi]
AB  - Making decisions on the basis of evidence is a central tenet of all health-care
      disciplines, including public health. However, it is not entirely clear what it
      means to base decisions on evidence; debates on evidence-based approaches often
      lack a clear understanding of the nature of evidence and obscure the normative
      underpinnings of evidence. Public health decision making requires an acceptance
      of limitations such as the availability of funding for research to provide
      complete evidence for any given decision, the ethical constraints on the creation
      of certain types of evidence and the ongoing dilemma between the need to take
      action and the need to gather more information. Using the example of the SARS
      outbreak in Canada, the inter-relationships between evidence and ethics are
      explored. I outline a set of critical questions for the global public health
      community to discuss regarding the nature of the relationship between
      evidence-based public health practice and ethics.
FAU - Upshur, Ross E G
AU  - Upshur RE
AD  - Department of Family and Community Medicine, Canada Research Chair in Primary
      Care Research, University of Toronto. ross.upshur@sunnybrook.ca
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - N S W Public Health Bull
JT  - New South Wales public health bulletin
JID - 9712270
SB  - IM
MH  - Blood Banks/standards
MH  - Canada/epidemiology
MH  - Decision Making
MH  - Disease Outbreaks
MH  - Evidence-Based Practice/*ethics/standards
MH  - Humans
MH  - Infection Control/methods
MH  - Public Health/*ethics
MH  - Quarantine/ethics
MH  - Severe Acute Respiratory Syndrome/*epidemiology/prevention & control/transmission
EDAT- 2012/06/29 06:00
MHDA- 2012/09/19 06:00
CRDT- 2012/06/29 06:00
PHST- 2012/06/29 06:00 [entrez]
PHST- 2012/06/29 06:00 [pubmed]
PHST- 2012/09/19 06:00 [medline]
AID - NB11044 [pii]
AID - 10.1071/NB11044 [doi]
PST - ppublish
SO  - N S W Public Health Bull. 2012 May-Jun;23(5-6):108-10. doi: 10.1071/NB11044.


PMID- 22738618
OWN - NLM
STAT- MEDLINE
DCOM- 20120918
LR  - 20151119
IS  - 1839-4345 (Electronic)
IS  - 1034-7674 (Linking)
VI  - 23
IP  - 5-6
DP  - 2012 May-Jun
TI  - Public health ethics: informing better public health practice.
PG  - 101-6
LID - 10.1071/NB12066 [doi]
AB  - Public health ethics has emerged and grown as an independent discipline over the 
      last decade. It involves using ethical theory and empirical analyses to determine
      and justify the right thing to do in public health. In this paper, we distinguish
      public health ethics from clinical ethics, research ethics, public health law and
      politics. We then discuss issues in public health ethics including: how to weigh 
      up the benefits, harms and costs of intervening; how to ensure that public health
      interventions produce fair outcomes; the potential for public health to undermine
      or promote the rights of citizens; and the significance of being transparent and 
      inclusive in public health interventions. We conclude that the explicit and
      systematic consideration of ethical issues will, and should, become central to
      every public health worker's daily practice.
FAU - Carter, Stacy M
AU  - Carter SM
AD  - Centre for Values, Ethics and the Law in Medicine, The University of Sydney.
      stacy.carter@sydney.edu.au
FAU - Kerridge, Ian
AU  - Kerridge I
FAU - Sainsbury, Peter
AU  - Sainsbury P
FAU - Letts, Julie K
AU  - Letts JK
LA  - eng
PT  - Introductory Journal Article
PL  - Australia
TA  - N S W Public Health Bull
JT  - New South Wales public health bulletin
JID - 9712270
SB  - IM
MH  - Civil Rights
MH  - Disclosure
MH  - *Ethics, Professional
MH  - Humans
MH  - Public Health/*instrumentation
EDAT- 2012/06/29 06:00
MHDA- 2012/09/19 06:00
CRDT- 2012/06/29 06:00
PHST- 2012/06/29 06:00 [entrez]
PHST- 2012/06/29 06:00 [pubmed]
PHST- 2012/09/19 06:00 [medline]
AID - NB12066 [pii]
AID - 10.1071/NB12066 [doi]
PST - ppublish
SO  - N S W Public Health Bull. 2012 May-Jun;23(5-6):101-6. doi: 10.1071/NB12066.


PMID- 22737792
OWN - NLM
STAT- MEDLINE
DCOM- 20160423
LR  - 20191112
IS  - 0102-6933 (Print)
IS  - 0102-6933 (Linking)
VI  - 33
IP  - 1
DP  - 2012 Mar
TI  - [The identification of anxiety through the analysis of the iris a possibility].
PG  - 26-31
AB  - Anxiety is a behavior related to psychosomatic diseases. Through an evaluation of
      the iris it is possible to determine personality traits and to intervene early to
      refrain any non-adaptive behavior from causing psychosomatic diseases.
      Contraction furrows suggest a predisposition to anxiety. This study aimed to
      verify the correlation of contraction furrows in the iris with the state-trait
      anxiety inventory (STAI). This study was approved by the Research Ethics
      Committee of the University of Sao Paulo, School of Nursing, and performed with
      62 teachers and employees at the Center of Health Science of the Zerbine
      Foundation (CeFACS), from May to July, 2010. The Spearman coefficient showed a
      positive and statistically significant correlation between the STAI score and the
      quantity of contraction furrows. This suggests that these signs indicate a
      predisposition to anxiety. With the early identification of this behavior we have
      chances to reduce the development of the disease.
FAU - Salles, Leia Fortes
AU  - Salles LF
AD  - Programa de Pos-Graduacao em Saude do Adulto da EE-USP, Sao Paulo, Brasil.
      leia.salles@usp.br
FAU - da Silva, Maria Julia Paes
AU  - da Silva MJ
LA  - por
PT  - Journal Article
TT  - A identificacao da ansiedade por meio da analise da iris: uma possibilidade.
PL  - Brazil
TA  - Rev Gaucha Enferm
JT  - Revista gaucha de enfermagem
JID - 8504882
MH  - *Anxiety/diagnosis
MH  - Humans
MH  - Iris
MH  - *Personality Inventory
EDAT- 2012/06/29 06:00
MHDA- 2016/04/24 06:00
CRDT- 2012/06/29 06:00
PHST- 2012/06/29 06:00 [entrez]
PHST- 2012/06/29 06:00 [pubmed]
PHST- 2016/04/24 06:00 [medline]
AID - 10.1590/s1983-14472012000100004 [doi]
PST - ppublish
SO  - Rev Gaucha Enferm. 2012 Mar;33(1):26-31. doi: 10.1590/s1983-14472012000100004.


PMID- 22737593
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220317
IS  - 2150-7740 (Print)
IS  - 2150-7759 (Linking)
VI  - 3
IP  - 1
DP  - 2012 Jan
TI  - Beyond Mere Symptom Relief in Deep Brain Stimulation: An Ethical Obligation for
      Multi-faceted Assessment of Outcome.
PG  - 44-49
AB  - Assessment of outcome following Deep Brain Stimulation (DBS) has traditionally
      focused on symptom specific and quality of life measures. Greater attention needs
      to be paid to the diversity of patient goals and values, as well as recognition
      of the shifting nature of those goals over the course of DBS therapy. We report
      preliminary data from an empirical study examining patients' goals with respect
      to DBS in the treatment of Parkinson disease. We argue that a multifaceted
      assessment of outcome over time, including well validated symptom measures,
      quality of life, functional and patient specific metrics, is ethically necessary 
      in order to fulfill fiduciary and professional responsibilities. These
      assessments should be augmented with a deliberative multi-disciplinary process of
      review and evaluation. Such an approach will lead to improved inform consent,
      promote better clinical research, and facilitate good patient care by providing a
      systematic mechanism for capturing and acting on important patient insights.
      These processes become increasingly critical as DBS begins to be applied to
      neuropsychiatric disorders.
FAU - Kubu, C S
AU  - Kubu CS
AD  - Cleveland Clinic.
FAU - Ford, P J
AU  - Ford PJ
LA  - eng
GR  - RC1 NS068086/NS/NINDS NIH HHS/United States
GR  - RC1 NS068086-01/NS/NINDS NIH HHS/United States
PT  - Journal Article
DEP - 20120105
PL  - United States
TA  - AJOB Neurosci
JT  - AJOB neuroscience
JID - 101518076
PMC - PMC3377486
MID - NIHMS352687
EDAT- 2012/06/28 06:00
MHDA- 2012/06/28 06:01
CRDT- 2012/06/28 06:00
PHST- 2012/06/28 06:00 [entrez]
PHST- 2012/06/28 06:00 [pubmed]
PHST- 2012/06/28 06:01 [medline]
AID - 10.1080/21507740.2011.633960 [doi]
PST - ppublish
SO  - AJOB Neurosci. 2012 Jan;3(1):44-49. doi: 10.1080/21507740.2011.633960. Epub 2012 
      Jan 5.


PMID- 22736753
OWN - NLM
STAT- MEDLINE
DCOM- 20130319
LR  - 20151119
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 19
IP  - 6
DP  - 2012 Nov
TI  - Influencers of ethical beliefs and the impact on moral distress and conscientious
      objection.
PG  - 738-49
LID - 10.1177/0969733011423409 [doi]
AB  - Considering a growing nurse shortage and the need for qualified nurses to handle 
      increasingly complex patient care situations, how ethical beliefs are influenced 
      and the consequences that can occur when moral conflicts of right and wrong arise
      need to be explored. The aim of this study was to explore influencers identified 
      by nurses as having the most impact on the development of their ethical beliefs
      and whether these influencers might impact levels of moral distress and the
      potential for conscientious objection. Nurses whose ethical beliefs were most
      influenced by their religious beliefs scored higher in levels of moral distress
      and demonstrated greater differences in areas of conscientious objection than did
      nurses who developed their ethical beliefs from influencers such as family
      values, life and work experience, political views or the professional code of
      ethics.
FAU - Davis, Shoni
AU  - Davis S
AD  - Boise State University, School of Nursing, ID 83725, USA.
      shonidavis@boisestate.edu
FAU - Schrader, Vivian
AU  - Schrader V
FAU - Belcheir, Marcia J
AU  - Belcheir MJ
LA  - eng
PT  - Journal Article
DEP - 20120625
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - *Attitude of Health Personnel
MH  - Conscience
MH  - Decision Making
MH  - *Ethics, Nursing
MH  - Female
MH  - Humans
MH  - Idaho
MH  - Male
MH  - Middle Aged
MH  - *Morals
MH  - Nursing Methodology Research
MH  - Nursing Staff/*psychology
MH  - *Stress, Psychological
MH  - Surveys and Questionnaires
EDAT- 2012/06/28 06:00
MHDA- 2013/03/21 06:00
CRDT- 2012/06/28 06:00
PHST- 2012/06/28 06:00 [entrez]
PHST- 2012/06/28 06:00 [pubmed]
PHST- 2013/03/21 06:00 [medline]
AID - 0969733011423409 [pii]
AID - 10.1177/0969733011423409 [doi]
PST - ppublish
SO  - Nurs Ethics. 2012 Nov;19(6):738-49. doi: 10.1177/0969733011423409. Epub 2012 Jun 
      25.


PMID- 22736296
OWN - NLM
STAT- MEDLINE
DCOM- 20130205
LR  - 20211021
IS  - 1097-0142 (Electronic)
IS  - 0008-543X (Linking)
VI  - 118
IP  - 24
DP  - 2012 Dec 15
TI  - Incorporating information regarding preimplantation genetic diagnosis into
      discussions concerning testing and risk management for BRCA1/2 mutations: a
      qualitative study of patient preferences.
PG  - 6270-7
LID - 10.1002/cncr.27695 [doi]
AB  - BACKGROUND: Studies have shown that BRCA1/2 mutation carriers are interested in
      learning about reproductive options such as preimplantation genetic diagnosis
      (PGD) to prevent passing their risk onto their children. However, attitudes vary 
      widely, and the procedure raises complex ethical and psychosocial issues. This
      complexity, plus the highly technical nature of PGD, makes it difficult to
      integrate PGD information into genetic counseling sessions that already cover
      probabilistic, emotionally charged risk information. METHODS: A total of 33
      carriers of the BRCA1/2 mutation who were of reproductive age and had previously 
      undergone genetic counseling viewed a tutorial regarding PGD and were interviewed
      concerning their attitudes toward PGD and preferences about how to include PGD
      information in genetic counseling. RESULTS: The majority of participants
      preferred to be briefly informed of the availability of PGD information, and to
      receive written materials regarding PGD, but with the option of deferring
      detailed discussion if they already believed themselves to be overloaded or
      perceived that PGD was not immediately relevant to their risk management and/or
      childbearing plans. For some individuals, the stress of testing temporarily
      interfered with information processing, producing states of cognitive avoidance
      ("in a fog," or "tuning out"). Some preferred to discuss PGD with a physician
      with whom they had an ongoing relationship (eg, obstetrician/gynecologist,
      primary care provider, or oncologist). CONCLUSIONS: Providers offering cancer
      genetic testing may consider indicating the availability of PGD information to
      their patients, while attending to the patients' level of interest and ability to
      absorb information. Research is needed to link patient responses to information
      overload with psychosocial outcomes (eg, distress, and quality of
      decision-making). Continuing medical education is needed to support providers in 
      facilitating informed decisions regarding PGD.
CI  - Copyright (c) 2012 American Cancer Society.
FAU - Hurley, Karen
AU  - Hurley K
AD  - Department of Psychiatry and Behavioral Science, Memorial Sloan-Kettering Cancer 
      Center, New York, New York, USA.
FAU - Rubin, Lisa R
AU  - Rubin LR
FAU - Werner-Lin, Allison
AU  - Werner-Lin A
FAU - Sagi, Michal
AU  - Sagi M
FAU - Kemel, Yelena
AU  - Kemel Y
FAU - Stern, Rikki
AU  - Stern R
FAU - Phillips, Aliza
AU  - Phillips A
FAU - Cholst, Ina
AU  - Cholst I
FAU - Kauff, Noah
AU  - Kauff N
FAU - Offit, Kenneth
AU  - Offit K
LA  - eng
GR  - R03 HG004528/HG/NHGRI NIH HHS/United States
GR  - R03 HG0004528/HG/NHGRI NIH HHS/United States
GR  - P30 CA008748/CA/NCI NIH HHS/United States
GR  - K07 CA109236/CA/NCI NIH HHS/United States
GR  - T32 CA009461/CA/NCI NIH HHS/United States
GR  - T32 CA009461-22/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120626
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
RN  - 0 (BRCA1 Protein)
RN  - 0 (BRCA1 protein, human)
RN  - 0 (BRCA2 Protein)
RN  - 0 (BRCA2 protein, human)
SB  - IM
MH  - Adult
MH  - BRCA1 Protein/*genetics
MH  - BRCA2 Protein/*genetics
MH  - Breast Neoplasms/diagnosis/genetics/psychology
MH  - Decision Making
MH  - Female
MH  - Genetic Counseling
MH  - Genetic Predisposition to Disease
MH  - Genetic Testing
MH  - Heterozygote
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mutation/*genetics
MH  - Ovarian Neoplasms/diagnosis/genetics/psychology
MH  - Patient Preference
MH  - Preimplantation Diagnosis/*trends
MH  - Prognosis
MH  - *Qualitative Research
MH  - *Risk Management
MH  - Surveys and Questionnaires
MH  - Young Adult
PMC - PMC4910088
MID - NIHMS746395
EDAT- 2012/06/28 06:00
MHDA- 2013/02/06 06:00
CRDT- 2012/06/28 06:00
PHST- 2012/01/26 00:00 [received]
PHST- 2012/05/11 00:00 [revised]
PHST- 2012/05/14 00:00 [accepted]
PHST- 2012/06/28 06:00 [entrez]
PHST- 2012/06/28 06:00 [pubmed]
PHST- 2013/02/06 06:00 [medline]
AID - 10.1002/cncr.27695 [doi]
PST - ppublish
SO  - Cancer. 2012 Dec 15;118(24):6270-7. doi: 10.1002/cncr.27695. Epub 2012 Jun 26.


PMID- 22736225
OWN - NLM
STAT- MEDLINE
DCOM- 20121213
LR  - 20120711
IS  - 1573-2800 (Electronic)
IS  - 0004-0002 (Linking)
VI  - 41
IP  - 4
DP  - 2012 Aug
TI  - Report of the American Psychiatric Association Task Force on Treatment of Gender 
      Identity Disorder.
PG  - 759-96
LID - 10.1007/s10508-012-9975-x [doi]
AB  - Both the diagnosis and treatment of Gender Identity Disorder (GID) are
      controversial. Although linked, they are separate issues and the DSM does not
      evaluate treatments. The Board of Trustees (BOT) of the American Psychiatric
      Association (APA), therefore, formed a Task Force charged to perform a critical
      review of the literature on the treatment of GID at different ages, to assess the
      quality of evidence pertaining to treatment, and to prepare a report that
      included an opinion as to whether or not sufficient credible literature exists
      for development of treatment recommendations by the APA. The literature on
      treatment of gender dysphoria in individuals with disorders of sex development
      was also assessed. The completed report was accepted by the BOT on September 11, 
      2011. The quality of evidence pertaining to most aspects of treatment in all
      subgroups was determined to be low; however, areas of broad clinical consensus
      were identified and were deemed sufficient to support recommendations for
      treatment in all subgroups. With subjective improvement as the primary outcome
      measure, current evidence was judged sufficient to support recommendations for
      adults in the form of an evidence-based APA Practice Guideline with gaps in the
      empirical data supplemented by clinical consensus. The report recommends that the
      APA take steps beyond drafting treatment recommendations. These include issuing
      position statements to clarify the APA's position regarding the medical necessity
      of treatments for GID, the ethical bounds of treatments of gender variant minors,
      and the rights of persons of any age who are gender variant, transgender or
      transsexual.
FAU - Byne, William
AU  - Byne W
AD  - Department of Psychiatry, JJ Peters VA Medical Center, Bronx, NY, USA.
      William.Byne@mssm.edu
FAU - Bradley, Susan J
AU  - Bradley SJ
FAU - Coleman, Eli
AU  - Coleman E
FAU - Eyler, A Evan
AU  - Eyler AE
FAU - Green, Richard
AU  - Green R
FAU - Menvielle, Edgardo J
AU  - Menvielle EJ
FAU - Meyer-Bahlburg, Heino F L
AU  - Meyer-Bahlburg HF
FAU - Pleak, Richard R
AU  - Pleak RR
FAU - Tompkins, D Andrew
AU  - Tompkins DA
CN  - American Psychiatric Association Task Force on Treatment of Gender Identity
      Disorder
LA  - eng
PT  - Journal Article
PT  - Practice Guideline
PL  - United States
TA  - Arch Sex Behav
JT  - Archives of sexual behavior
JID - 1273516
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Consensus
MH  - *Evidence-Based Medicine
MH  - Female
MH  - *Gender Identity
MH  - Humans
MH  - Male
MH  - Transsexualism/psychology/*therapy
EDAT- 2012/06/28 06:00
MHDA- 2012/12/14 06:00
CRDT- 2012/06/28 06:00
PHST- 2012/06/28 06:00 [entrez]
PHST- 2012/06/28 06:00 [pubmed]
PHST- 2012/12/14 06:00 [medline]
AID - 10.1007/s10508-012-9975-x [doi]
PST - ppublish
SO  - Arch Sex Behav. 2012 Aug;41(4):759-96. doi: 10.1007/s10508-012-9975-x.


PMID- 22735817
OWN - NLM
STAT- MEDLINE
DCOM- 20121126
LR  - 20220409
IS  - 1945-404X (Electronic)
IS  - 0090-7421 (Linking)
VI  - 41
IP  - 2
DP  - 2012 Summer
TI  - Current and future instructional methods and influencing factors in anatomy
      instruction in physical therapy and medical schools in the U.S.
PG  - 53-62
AB  - UNLABELLED: The purpose of this descriptive study was to investigate current and 
      future instructional practices and the most important factors influencing those
      practices in anatomy laboratories within medical schools and physical therapy
      schools. METHODS: A survey instrument was developed using the Delphi method in
      2008. In addition to refining the survey instrument, the participants in the
      Delphi study also provided their expert testimony on current and future teaching 
      methods as well as influencing factors. The survey was then administered in 2009 
      to a random sampling of anatomy instructors in physical therapy (n = 60) and
      medical schools (n = 15). RESULTS: Cadaver dissection is currently the most
      common instructional technique, but its use is predicted by our experts and our
      general survey respondents to decline by 2020 in both medical and physical
      therapy schools. In the future, more instructional time will be devoted to
      imaging, computerized teaching aids, living/surface anatomy instruction, and
      prosections. The most important factors influencing anatomy education for all
      groups were budget, instructional time, and the availability of qualified anatomy
      instructors. Factors predicted to have little influence on anatomy instruction
      include student learning styles and ethical considerations. Contrary to current
      concerns expressed by some, health and safety concerns were also judged to have
      little influence on anatomy instruction. CONCLUSION: Evidence supports a trend of
      decreasing time on cadaver dissection and increasing time on technology-based
      instructional methods.
FAU - Gabard, Donald L
AU  - Gabard DL
AD  - Physical Therapy Department, Chapman University, Orange, CA, USA.
      gabard@chapman.edu
FAU - Lowe, Deborah L
AU  - Lowe DL
FAU - Chang, Julia W
AU  - Chang JW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Allied Health
JT  - Journal of allied health
JID - 0361603
SB  - IM
MH  - Anatomy/*education
MH  - Data Collection
MH  - Delphi Technique
MH  - Humans
MH  - Physical Therapy Specialty/*education
MH  - *Schools, Medical
MH  - Teaching/*methods
MH  - United States
EDAT- 2012/06/28 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/06/28 06:00
PHST- 2011/03/19 00:00 [received]
PHST- 2012/02/11 00:00 [accepted]
PHST- 2012/06/28 06:00 [entrez]
PHST- 2012/06/28 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
PST - ppublish
SO  - J Allied Health. 2012 Summer;41(2):53-62.


PMID- 22735560
OWN - NLM
STAT- MEDLINE
DCOM- 20120904
LR  - 20181201
IS  - 1938-808X (Electronic)
IS  - 1040-2446 (Linking)
VI  - 87
IP  - 7
DP  - 2012 Jul
TI  - Commentary: labeling institutional review board members does not lead to better
      protections for research participants.
PG  - 842-4
LID - 10.1097/ACM.0b013e318257f115 [doi]
AB  - Much of the academic medicine community's confusion over institutional review
      board (IRB) composition and representation stems from the federal regulations
      themselves. The intent of these regulations is twofold-to ensure that IRBs are
      properly composed to review research proposals and to garner respect from the
      community for the decisions that they make.Klitzman's research, presented in this
      issue of Academic Medicine, looks at the roles of nonaffiliated and nonscientific
      IRB members. He found that those whom he interviewed, primarily IRB chairs,
      directors, and administrators, were confused about the role of these
      nonaffiliated and nonscientific members, how to train them, and how to engage
      them when reviewing protocols.The authors recommend moving away from a system of 
      labeling IRB members (as scientific, nonaffiliated, etc.) and returning to the
      intent of the federal regulations-ensuring that the composition of the IRB
      results in an ethical review of the research. Every IRB appointment and every
      member's qualifications should be evaluated in light of the intentions of the
      federal regulations and the requirement that the IRB meet them. For example, if
      an individual's primary concerns are in scientific areas, the IRB should identify
      the individual as such, doing the same for those whose primary concerns are
      nonscientific. If the IRB needs individuals whose primary concerns are in
      nonscientific areas to represent the perspectives of human subjects, then it
      should recruit current or former research subjects for these positions. These
      changes would strengthen both the review process and the quality of the research.
FAU - Speers, Marjorie A
AU  - Speers MA
AD  - Association for the Accreditation of Human Research Protection Programs, Inc.,
      Washington, DC 20037, USA. mspeers@aahrpp.org
FAU - Rose, Susan
AU  - Rose S
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Acad Med
JT  - Academic medicine : journal of the Association of American Medical Colleges
JID - 8904605
SB  - IM
CON - Acad Med. 2012 Jul;87(7):975-81. PMID: 22622206
MH  - *Committee Membership
MH  - *Community Participation
MH  - Ethics Committees, Research/*organization & administration
MH  - Female
MH  - Humans
MH  - Male
EDAT- 2012/06/28 06:00
MHDA- 2012/09/05 06:00
CRDT- 2012/06/28 06:00
PHST- 2012/06/28 06:00 [entrez]
PHST- 2012/06/28 06:00 [pubmed]
PHST- 2012/09/05 06:00 [medline]
AID - 10.1097/ACM.0b013e318257f115 [doi]
AID - 00001888-201207000-00009 [pii]
PST - ppublish
SO  - Acad Med. 2012 Jul;87(7):842-4. doi: 10.1097/ACM.0b013e318257f115.


PMID- 22735226
OWN - NLM
STAT- MEDLINE
DCOM- 20130329
LR  - 20220310
IS  - 1806-9282 (Electronic)
IS  - 0104-4230 (Linking)
VI  - 58
IP  - 3
DP  - 2012 May-Jun
TI  - Patient prioritization in medical emergencies: an ethical analysis.
PG  - 335-40
LID - S0104-42302012000300014 [pii]
AB  - OBJECTIVE: To identify and analyze, in the light of ethical considerations, the
      choices and justifications of public health professionals in hypothetical
      situations of patient prioritization in circumstances of limited resources during
      emergency medical care. METHODS: Qualitative and quantitative study, carried out 
      through interviews with 80 public health professionals, graduate students (MSc
      and PhD students) in public health who were faced with hypothetical situations
      involving the criteria of gender, age, and responsibility, asked to choose
      between alternatives that referred to the existence of people, equally submitted 
      to life-threatening situations, who needed care in an emergency department.
      RESULTS: The choices prioritized children, young individuals, women, and married 
      women, with decision-making invoking the ethical principles of vulnerability,
      social utility, and equity. CONCLUSION: The study shows a clear tendency to
      justify the choices that were made, guided by utilitarian ethics.
FAU - Fortes, Paulo Antonio de Carvalho
AU  - Fortes PA
AD  - Universidade de Sao Paulo, Av. Dr. Arnaldo 715, Sao Paulo, SP, Brazil.
      pacfusp@usp.br
FAU - Pereira, Patricia Cristina Andrade
AU  - Pereira PC
LA  - eng
LA  - por
PT  - Journal Article
PL  - Brazil
TA  - Rev Assoc Med Bras (1992)
JT  - Revista da Associacao Medica Brasileira (1992)
JID - 9308586
SB  - IM
MH  - Adult
MH  - Aged
MH  - Child
MH  - Decision Making/*ethics
MH  - Emergency Medical Services/*ethics
MH  - *Ethical Analysis
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Middle Aged
MH  - Patient Selection/*ethics
MH  - Public Health/*ethics
MH  - Qualitative Research
MH  - Social Values
MH  - Value of Life
MH  - Young Adult
EDAT- 2012/06/28 06:00
MHDA- 2013/03/30 06:00
CRDT- 2012/06/28 06:00
PHST- 2011/09/20 00:00 [received]
PHST- 2012/01/28 00:00 [accepted]
PHST- 2012/06/28 06:00 [entrez]
PHST- 2012/06/28 06:00 [pubmed]
PHST- 2013/03/30 06:00 [medline]
AID - S0104-42302012000300014 [pii]
PST - ppublish
SO  - Rev Assoc Med Bras (1992). 2012 May-Jun;58(3):335-40.


PMID- 22735165
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 3
DP  - 2012
TI  - Socioeconomic inequalities in the rate of stillbirths by cause: a
      population-based study.
LID - 10.1136/bmjopen-2012-001100 [doi]
LID - e001100 [pii]
AB  - OBJECTIVE: To assess time trends in socioeconomic inequalities in overall and
      cause-specific stillbirth rates in England. DESIGN: Population-based
      retrospective study. SETTING: England. PARTICIPANTS: Stillbirths occurring among 
      singleton infants born between 1 January 2000 and 31 December 2007. MAIN OUTCOME 
      MEASURE: Cause-specific stillbirth rate per 10 000 births by deprivation tenth
      and year of birth. Deprivation measured using the UK index of multiple
      deprivation at Super Output Area level. METHODS: Poisson regression models were
      used to estimate the relative deprivation gap (comparing the most and least
      deprived tenths) in rates of stillbirths (overall and cause-specific). Excess
      mortality was calculated by applying the rates seen in the least deprived tenth
      to the entire population at risk. Discussions with our local NHS multicentre
      ethics committee deemed that this analysis of national non-identifiable data did 
      not require separate ethics approval. RESULTS: There were 44 stillbirths per 10
      000 births, with no evidence of a change in rates over time. Rates were twice as 
      high in the most deprived tenth compared with the least (rate ratio (RR) 2.1, 95%
      CI 2.0 to 2.2) with no evidence of a change over time. There was a significant
      deprivation gap for all specific causes except mechanical events (RR 1.2, 95% CI 
      0.9 to 1.5). The widest gap was seen for stillbirths due to antepartum
      haemorrhages (RR 3.1, 95% CI 2.8 to 3.5). No evidence of a change in the rate of 
      stillbirth or deprivation gap over time was seen for any specific cause.
      CONCLUSION: A wide deprivation gap exists in stillbirth rates for most causes and
      is not diminishing. Unexplained antepartum stillbirths accounted for 50% of the
      deprivation gap, and a better understanding of these stillbirths is necessary to 
      reduce socioeconomic inequalities.
FAU - Seaton, Sarah E
AU  - Seaton SE
AD  - Department of Health Sciences, University of Leicester, Leicester, UK.
FAU - Field, David J
AU  - Field DJ
FAU - Draper, Elizabeth S
AU  - Draper ES
FAU - Manktelow, Bradley N
AU  - Manktelow BN
FAU - Smith, Gordon C S
AU  - Smith GC
FAU - Springett, Anna
AU  - Springett A
FAU - Smith, Lucy K
AU  - Smith LK
LA  - eng
GR  - MET-08-05-101/DH_/Department of Health/United Kingdom
GR  - NIHR-MET-08-05/DH_/Department of Health/United Kingdom
GR  - RP-PG-0407-10029/DH_/Department of Health/United Kingdom
PT  - Journal Article
DEP - 20120625
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3383980
EDAT- 2012/06/28 06:00
MHDA- 2012/06/28 06:01
CRDT- 2012/06/28 06:00
PHST- 2012/06/28 06:00 [entrez]
PHST- 2012/06/28 06:00 [pubmed]
PHST- 2012/06/28 06:01 [medline]
AID - bmjopen-2012-001100 [pii]
AID - 10.1136/bmjopen-2012-001100 [doi]
PST - epublish
SO  - BMJ Open. 2012 Jun 25;2(3). pii: bmjopen-2012-001100. doi:
      10.1136/bmjopen-2012-001100. Print 2012.


PMID- 22734628
OWN - NLM
STAT- MEDLINE
DCOM- 20131122
LR  - 20220409
IS  - 1471-6712 (Electronic)
IS  - 0283-9318 (Linking)
VI  - 27
IP  - 1
DP  - 2013 Mar
TI  - The butterfly effect of caring - clinical nursing teachers' understanding of
      self-compassion as a source to compassionate care.
PG  - 175-83
LID - 10.1111/j.1471-6712.2012.01033.x [doi]
AB  - This study has its roots in a clinical application project, focusing on the
      development of a teaching-learning model enabling participants to understand
      compassion. During that project four clinical nursing teachers met for a total of
      12 hours of experiential and reflective work. This study aimed at exploring
      participants' understanding of self-compassion as a source to compassionate care.
      It was carried out as a phenomenological and hermeneutic interpretation of
      participants' written and oral reflections on the topic. Data were interpreted in
      the light of Watson's Theory of Human Caring. Five themes were identified: Being 
      there, with self and others; respect for human vulnerability; being
      nonjudgmental; giving voice to things needed to be said and heard; and being able
      to accept the gift of compassion from others. A main metaphorical theme, 'the
      Butterfly effect of Caring', was identified, addressing interdependency and the
      ethics of the face and hand when caring for Other - the ethical stance where the 
      Other's vulnerable face elicits a call for compassionate actions. The findings
      reveal that the development of a compassionate self and the ability to be
      sensitive, nonjudgmental and respectful towards oneself contributes to a
      compassionate approach towards others. It is concluded that compassionate care is
      not only something the caregiver does, nor is compassion reduced to a way of
      being with another person or a feeling. Rather, it is a way of becoming and
      belonging together with another person where both are mutually engaged and where 
      the caregiver compassionately is able to acknowledge both self and Other's
      vulnerability and dignity.
CI  - (c) 2012 The Authors. Scandinavian Journal of Caring Sciences (c) 2012 Nordic
      College of Caring Science.
FAU - Wiklund Gustin, Lena
AU  - Wiklund Gustin L
AD  - School of Health, Care and Social Welfare, Malardalen University, Vasteras,
      Sweden. lena.wiklund@mdh.se
FAU - Wagner, Lynne
AU  - Wagner L
LA  - eng
PT  - Journal Article
DEP - 20120627
PL  - Sweden
TA  - Scand J Caring Sci
JT  - Scandinavian journal of caring sciences
JID - 8804206
MH  - Education, Nursing
MH  - *Empathy
MH  - *Faculty, Nursing
MH  - Humans
EDAT- 2012/06/28 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/06/28 06:00
PHST- 2012/06/28 06:00 [entrez]
PHST- 2012/06/28 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1111/j.1471-6712.2012.01033.x [doi]
PST - ppublish
SO  - Scand J Caring Sci. 2013 Mar;27(1):175-83. doi: 10.1111/j.1471-6712.2012.01033.x.
      Epub 2012 Jun 27.


PMID- 22734122
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 3
DP  - 2012
TI  - Network structure and the role of key players in a translational cancer research 
      network: a study protocol.
LID - 10.1136/bmjopen-2012-001434 [doi]
LID - e001434 [pii]
AB  - INTRODUCTION: Translational research networks are a deliberate strategy to bridge
      the gulf between biomedical research and clinical practice through
      interdisciplinary collaboration, supportive funding and infrastructure. The
      social network approach examines how the structure of the network and players who
      hold important positions within it constrain or enable function. This information
      can be used to guide network management and optimise its operations. The aim of
      this study was to describe the structure of a translational cancer research
      network (TCRN) in Australia over its first year, identify the key players within 
      the network and explore these players' opportunities and constraints in
      maximising important network collaborations. METHODS AND ANALYSIS: This study
      deploys a mixed-method longitudinal design using social network analysis
      augmented by interviews and review of TCRN documents. The study will use network 
      documents and interviews with governing body members to explore the broader
      context into which the network is embedded as well as the perceptions and
      expectations of members. Of particular interest are the attitudes and perceptions
      of clinicians compared with those of researchers. A co-authorship network will be
      constructed of TCRN members using journal and citation databases to assess the
      success of past pre-network collaborations. Two whole network social network
      surveys will be administered 12 months apart and parameters such as density,
      clustering, centrality and betweenness centrality computed and compared using
      UCINET and Netdraw. Key players will be identified and interviewed to understand 
      the specific activities, barriers and enablers they face in that role. ETHICS AND
      DISSEMINATION: Ethics approvals were obtained from the University of New South
      Wales, South Eastern Sydney Northern Sector Local Health Network and Calvary
      Health Care Sydney. Results will be discussed with members of the TCRN, submitted
      to relevant journals and presented as oral presentations to clinicians,
      researchers and policymakers.
FAU - Long, Janet C
AU  - Long JC
AD  - Centre for Clinical Governance Research, University of New South Wales,
      Kensington, New South Wales, Australia.
FAU - Cunningham, Frances C
AU  - Cunningham FC
FAU - Braithwaite, Jeffrey
AU  - Braithwaite J
LA  - eng
PT  - Journal Article
DEP - 20120625
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3383981
EDAT- 2012/06/27 06:00
MHDA- 2012/06/27 06:01
CRDT- 2012/06/27 06:00
PHST- 2012/06/27 06:00 [entrez]
PHST- 2012/06/27 06:00 [pubmed]
PHST- 2012/06/27 06:01 [medline]
AID - bmjopen-2012-001434 [pii]
AID - 10.1136/bmjopen-2012-001434 [doi]
PST - epublish
SO  - BMJ Open. 2012 Jun 25;2(3). pii: bmjopen-2012-001434. doi:
      10.1136/bmjopen-2012-001434. Print 2012.


PMID- 22734121
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 3
DP  - 2012
TI  - Protocol for an observation and implementation study investigating optimisation
      of the management of stroke and transient ischaemic attack (TIA).
LID - 10.1136/bmjopen-2012-001430 [doi]
LID - e001430 [pii]
AB  - INTRODUCTION: Patients benefit from early and intensive treatment in both acute
      ischaemic stroke and transient ischaemic attack. Recent audits of acute
      stroke/transient ischaemic attack care suggest that although standards have
      improved, current services still fall short of optimal care. The aim of this
      study is to establish a database of patients accessing stroke services. Data will
      be collected and analysed to provide individualised feedback to healthcare
      professionals who can then use these findings to develop strategies for service
      improvement. METHODS AND ANALYSIS: This longitudinal observational study will
      evolve with the ongoing findings from the research output. The project will
      consist of three phases: assessment of current practice, feedback of findings and
      evaluation of service change. Consecutive patients will be recruited from
      participating hospitals, and identifiable data will be collected to link records 
      from the Primary Care, Secondary Care and Emergency Services. As this study
      focuses on observation of current practice, a sample size calculation is not
      deemed appropriate. Patients will be sent follow-up questionnaires examining
      quality of life at 3 and 12 months post-event. Qualitative interviews will
      examine the care pathway through the experiences of patients, their carers,
      healthcare personnel and commissioners. Collected data will be used in economic
      analyses, which will evaluate the impact of current care and service redesign on 
      the NHS costs and patient outcomes (death and quality of life). ETHICS AND
      DISSEMINATION: Ethical approval for this study has been obtained from the
      National Research Ethics Committee (reference; 09/H0716/71), and site-specific
      R&D approval has been acquired from the relevant NHS trusts. All findings will be
      presented at relevant healthcare/academic conferences and written up for
      publication in peer-reviewed journals. Results will be fed back to patients and
      participating trusts through a series of reports and presentations. These will be
      used to facilitate discussions about service redesign and implementation.
FAU - Sheppard, James Peter
AU  - Sheppard JP
AD  - Department of Primary Care Clinical Sciences, University of Birmingham,
      Birmingham, UK.
FAU - Mellor, Ruth Mary
AU  - Mellor RM
FAU - Bailey, Sheila Marie
AU  - Bailey SM
FAU - Barton, Pelham
AU  - Barton P
FAU - Boyal, Amunpreet
AU  - Boyal A
FAU - Greenfield, Sheila
AU  - Greenfield S
FAU - Jowett, Sue
AU  - Jowett S
FAU - Mant, Jonathan
AU  - Mant J
FAU - Quinn, Tom
AU  - Quinn T
FAU - Singh, Satinder
AU  - Singh S
FAU - McManus, Richard J
AU  - McManus RJ
CN  - BBC CLAHRC Investigators
LA  - eng
GR  - CDF/01/017/DH_/Department of Health/United Kingdom
PT  - Journal Article
DEP - 20120625
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3383985
EDAT- 2012/06/27 06:00
MHDA- 2012/06/27 06:01
CRDT- 2012/06/27 06:00
PHST- 2012/06/27 06:00 [entrez]
PHST- 2012/06/27 06:00 [pubmed]
PHST- 2012/06/27 06:01 [medline]
AID - bmjopen-2012-001430 [pii]
AID - 10.1136/bmjopen-2012-001430 [doi]
PST - epublish
SO  - BMJ Open. 2012 Jun 25;2(3). pii: bmjopen-2012-001430. doi:
      10.1136/bmjopen-2012-001430. Print 2012.


PMID- 22734120
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 3
DP  - 2012
TI  - Screening Education And Recognition in Community pHarmacies of Atrial
      Fibrillation to prevent stroke in an ambulant population aged >=65 years
      (SEARCH-AF stroke prevention study): a cross-sectional study protocol.
LID - 10.1136/bmjopen-2012-001355 [doi]
LID - e001355 [pii]
AB  - BACKGROUND: Atrial fibrillation (AF) is associated with a high risk of stroke and
      may often be asymptomatic. AF is commonly undiagnosed until patients present with
      sequelae, such as heart failure and stroke. Stroke secondary to AF is highly
      preventable with the use of appropriate thromboprophylaxis. Therefore, early
      identification and appropriate evidence-based management of AF could lead to
      subsequent stroke prevention. This study aims to determine the feasibility and
      impact of a community pharmacy-based screening programme focused on identifying
      undiagnosed AF in people aged 65 years and older. METHODS AND ANALYSIS: This
      cross-sectional study of community-based screening to identify undiagnosed AF
      will evaluate the feasibility of screening for AF using a pulse palpation and
      handheld single-lead electrocardiograph (ECG) device. 10 community pharmacies
      will be recruited and trained to implement the screening protocol, targeting a
      total of 1000 participants. The primary outcome is the proportion of people newly
      identified with AF at the completion of the screening programme. Secondary
      outcomes include level of agreement between the pharmacist's and the
      cardiologist's interpretation of the single-lead ECG; level of agreement between 
      irregular rhythm identified with pulse palpation and with the single-lead ECG.
      Process outcomes related to sustainability of the screening programme beyond the 
      trial setting, pharmacist knowledge of AF and rate of uptake of referral to full 
      ECG evaluation and cardiology review will also be collected. ETHICS AND
      DISSEMINATION: Primary ethics approval was received on 26 March 2012 from Sydney 
      Local Health District Human Research Ethics Committee-Concord Repatriation
      General Hospital zone. Results will be disseminated via forums including, but not
      limited to, peer-reviewed publication and presentation at national and
      international conferences. CLINICAL TRIALS REGISTRATION NUMBER:
      ACTRN12612000406808.
FAU - Lowres, Nicole
AU  - Lowres N
AD  - Department of Cardiology, Concord Repatriation General Hospital, Sydney,
      Australia.
FAU - Freedman, Saul Benedict
AU  - Freedman SB
FAU - Redfern, Julie
AU  - Redfern J
FAU - McLachlan, Andrew
AU  - McLachlan A
FAU - Krass, Ines
AU  - Krass I
FAU - Bennett, Alexandra
AU  - Bennett A
FAU - Briffa, Thomas
AU  - Briffa T
FAU - Bauman, Adrian
AU  - Bauman A
FAU - Neubeck, Lis
AU  - Neubeck L
LA  - eng
PT  - Journal Article
DEP - 20120625
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3383976
EDAT- 2012/06/27 06:00
MHDA- 2012/06/27 06:01
CRDT- 2012/06/27 06:00
PHST- 2012/06/27 06:00 [entrez]
PHST- 2012/06/27 06:00 [pubmed]
PHST- 2012/06/27 06:01 [medline]
AID - bmjopen-2012-001355 [pii]
AID - 10.1136/bmjopen-2012-001355 [doi]
PST - epublish
SO  - BMJ Open. 2012 Jun 25;2(3). pii: bmjopen-2012-001355. doi:
      10.1136/bmjopen-2012-001355. Print 2012.


PMID- 22734119
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 3
DP  - 2012
TI  - Acupuncture for acute non-specific low back pain: a protocol for a randomised,
      controlled multicentre intervention study in general practice--the Acuback Study.
LID - 10.1136/bmjopen-2012-001164 [doi]
LID - e001164 [pii]
AB  - INTRODUCTION: Some general practitioners (GPs) treat acute low back pain (LBP)
      with acupuncture, despite lacking evidence of its effectiveness for this
      condition. The aim of this study was to evaluate whether a single treatment
      session with acupuncture can reduce time to recovery when applied in addition to 
      standard LBP treatment according to the Norwegian national guidelines. Analyses
      of prognostic factors for recovery and cost-effectiveness will also be carried
      out. METHODS AND ANALYSIS: In this randomised, controlled multicentre study in
      general practice in Southern Norway, 270 patients will be allocated into one of
      two treatment groups, using a web-based application based on block randomisation.
      Outcome assessor will be blinded for group allocation of the patients. The
      control group will receive standard treatment, while the intervention group will 
      receive standard treatment plus acupuncture treatment. There will be different
      GPs treating the two groups, and both groups will just have one consultation.
      Adults who consult their GP because of acute LBP will be included. Patients with 
      nerve root affection, 'red flags', pregnancy, previous sick leave more than 14
      days and disability pension will be excluded. The primary outcome of the study is
      the median time to recovery (in days). The secondary outcomes are rated global
      improvement, back-specific functional status, sick leave, medication, GP visits
      and side effects. A pilot study will be conducted. ETHICS AND DISSEMINATION:
      Participation is based on informed written consent. The authors will apply for an
      ethical approval from the Regional Committee for Medical and Health Research
      Ethics when the study protocol is published. Results from this study, positive or
      negative, will be disseminated in scientific medical journals. TRIAL REGISTRATION
      NUMBER: ClinicalTrials.gov Identifier: NCT01439412.
FAU - Skonnord, Trygve
AU  - Skonnord T
AD  - Department of General Practice, Institute of Health and Society, University of
      Oslo, Oslo, Norway.
FAU - Skjeie, Holgeir
AU  - Skjeie H
FAU - Brekke, Mette
AU  - Brekke M
FAU - Grotle, Margreth
AU  - Grotle M
FAU - Lund, Irene
AU  - Lund I
FAU - Fetveit, Arne
AU  - Fetveit A
LA  - eng
SI  - ClinicalTrials.gov/NCT01439412
PT  - Journal Article
DEP - 20120625
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3383982
EDAT- 2012/06/27 06:00
MHDA- 2012/06/27 06:01
CRDT- 2012/06/27 06:00
PHST- 2012/06/27 06:00 [entrez]
PHST- 2012/06/27 06:00 [pubmed]
PHST- 2012/06/27 06:01 [medline]
AID - bmjopen-2012-001164 [pii]
AID - 10.1136/bmjopen-2012-001164 [doi]
PST - epublish
SO  - BMJ Open. 2012 Jun 25;2(3). pii: bmjopen-2012-001164. doi:
      10.1136/bmjopen-2012-001164. Print 2012.


PMID- 22733977
OWN - NLM
STAT- MEDLINE
DCOM- 20130523
LR  - 20211021
IS  - 1527-974X (Electronic)
IS  - 1067-5027 (Linking)
VI  - 20
IP  - 1
DP  - 2013 Jan 1
TI  - AMIA's code of professional and ethical conduct.
PG  - 141-3
LID - 10.1136/amiajnl-2012-001035 [doi]
FAU - Goodman, Kenneth W
AU  - Goodman KW
AD  - Ethics Programs, University of Miami, Miami, FL 33101, USA.
      kgoodman@med.miami.edu
FAU - Adams, Samantha
AU  - Adams S
FAU - Berner, Eta S
AU  - Berner ES
FAU - Embi, Peter J
AU  - Embi PJ
FAU - Hsiung, Robert
AU  - Hsiung R
FAU - Hurdle, John
AU  - Hurdle J
FAU - Jones, Dixie A
AU  - Jones DA
FAU - Lehmann, Christoph U
AU  - Lehmann CU
FAU - Maulden, Sarah
AU  - Maulden S
FAU - Petersen, Carolyn
AU  - Petersen C
FAU - Terrazas, Enrique
AU  - Terrazas E
FAU - Winkelstein, Peter
AU  - Winkelstein P
LA  - eng
PT  - Journal Article
DEP - 20120625
PL  - England
TA  - J Am Med Inform Assoc
JT  - Journal of the American Medical Informatics Association : JAMIA
JID - 9430800
SB  - IM
MH  - *Codes of Ethics
MH  - Humans
MH  - Medical Informatics/*ethics
MH  - Societies, Scientific/*ethics
MH  - United States
PMC - PMC3555329
EDAT- 2012/06/27 06:00
MHDA- 2013/05/25 06:00
CRDT- 2012/06/27 06:00
PHST- 2012/06/27 06:00 [entrez]
PHST- 2012/06/27 06:00 [pubmed]
PHST- 2013/05/25 06:00 [medline]
AID - amiajnl-2012-001035 [pii]
AID - 10.1136/amiajnl-2012-001035 [doi]
PST - ppublish
SO  - J Am Med Inform Assoc. 2013 Jan 1;20(1):141-3. doi: 10.1136/amiajnl-2012-001035. 
      Epub 2012 Jun 25.


PMID- 22733329
OWN - NLM
STAT- MEDLINE
DCOM- 20120727
LR  - 20161125
IS  - 0093-0334 (Print)
IS  - 0093-0334 (Linking)
VI  - 42
IP  - 2
DP  - 2012 Mar-Apr
TI  - Ethical evasion or happenstance and hubris? The U.S. Public Health Service STD
      Inoculation Study.
PG  - 30-8
LID - 10.1002/hast.17 [doi]
AB  - It's tempting to explain the Guatemala STD inoculation study as an attempt to
      evade the strictures of U.S research ethics. In fact, the researchers appear to
      have had benign reasons for going abroad. Only after they reached Guatemala did
      the study fly out of control.
FAU - Lynch, Holly Fernandez
AU  - Lynch HF
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120228
PL  - United States
TA  - Hastings Cent Rep
JT  - The Hastings Center report
JID - 0410447
SB  - IM
CIN - Hastings Cent Rep. 2012 Mar-Apr;42(2):3. PMID: 22733319
MH  - Clinical Trials as Topic/ethics/*history
MH  - Ethics, Research/history
MH  - Guatemala
MH  - History, 20th Century
MH  - Humans
MH  - Indiana
MH  - Informed Consent/ethics/*history
MH  - *Prisoners
MH  - Public Health/*history/standards
MH  - Research Personnel/ethics/*history
MH  - *Research Subjects/supply & distribution
MH  - *Sex Work/history/legislation & jurisprudence
MH  - *Sex Workers/history
MH  - Sexually Transmitted Diseases/*history/prevention & control/transmission
MH  - Social Responsibility
MH  - United States
MH  - United States Public Health Service
MH  - Vaccination/ethics/*history
EDAT- 2012/06/27 06:00
MHDA- 2012/07/28 06:00
CRDT- 2012/06/27 06:00
PHST- 2012/06/27 06:00 [entrez]
PHST- 2012/06/27 06:00 [pubmed]
PHST- 2012/07/28 06:00 [medline]
AID - 10.1002/hast.17 [doi]
PST - ppublish
SO  - Hastings Cent Rep. 2012 Mar-Apr;42(2):30-8. doi: 10.1002/hast.17. Epub 2012 Feb
      28.


PMID- 22732855
OWN - NLM
STAT- MEDLINE
DCOM- 20121101
LR  - 20120626
IS  - 1473-5695 (Electronic)
IS  - 0969-9546 (Linking)
VI  - 19
IP  - 4
DP  - 2012 Aug
TI  - In-flight medical emergencies: ethical and clinical challenges.
PG  - 207
LID - 10.1097/MEJ.0b013e328356f569 [doi]
FAU - Cocks, Robert A
AU  - Cocks RA
FAU - Hung, Kevin K C
AU  - Hung KK
FAU - Graham, Colin A
AU  - Graham CA
LA  - eng
PT  - Editorial
PL  - England
TA  - Eur J Emerg Med
JT  - European journal of emergency medicine : official journal of the European Society
      for Emergency Medicine
JID - 9442482
SB  - IM
MH  - *Aircraft
MH  - Cardiopulmonary Resuscitation/*ethics/methods
MH  - Emergency Medical Services/*ethics/methods
MH  - Humans
MH  - Risk
EDAT- 2012/06/27 06:00
MHDA- 2012/11/02 06:00
CRDT- 2012/06/27 06:00
PHST- 2012/06/27 06:00 [entrez]
PHST- 2012/06/27 06:00 [pubmed]
PHST- 2012/11/02 06:00 [medline]
AID - 10.1097/MEJ.0b013e328356f569 [doi]
AID - 00063110-201208000-00001 [pii]
PST - ppublish
SO  - Eur J Emerg Med. 2012 Aug;19(4):207. doi: 10.1097/MEJ.0b013e328356f569.


PMID- 22732048
OWN - NLM
STAT- MEDLINE
DCOM- 20121022
LR  - 20120626
IS  - 1548-5609 (Electronic)
IS  - 1548-5595 (Linking)
VI  - 19
IP  - 4
DP  - 2012 Jul
TI  - Living donation: the global perspective.
PG  - 269-75
LID - 10.1053/j.ackd.2012.05.003 [doi]
AB  - Of 195 independent countries in the world, 83 have transplant programs. Some
      countries (areas) have emphasized living donation; others, decreased donation. As
      a consequence, rates of living donation vary widely between geographic areas and 
      often between countries within the same geographic area. The major ethical issue 
      in living donation is the risk to the donor. Internationally, numerous guidelines
      have been developed outlining acceptable donor evaluation and criteria for
      approval. An ongoing issue is that there remains considerable variation between
      countries (and programs within a country) in evaluation and in acceptance
      criteria. A major problem for most countries is the shortage of organs. As a
      consequence, illegal or quasi-legal unregulated markets have developed in some
      areas. These markets have not provided protection for either donor or recipient. 
      The transplant community has taken a unified stand against these underground
      unregulated markets.
CI  - Copyright (c) 2012 National Kidney Foundation, Inc. Published by Elsevier Inc.
      All rights reserved.
FAU - Matas, Arthur J
AU  - Matas AJ
AD  - Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA.
      matas001@umn.edu
FAU - Delmonico, Francis L
AU  - Delmonico FL
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Adv Chronic Kidney Dis
JT  - Advances in chronic kidney disease
JID - 101209214
SB  - IM
MH  - Coercion
MH  - Humans
MH  - Intestines/transplantation
MH  - Kidney Transplantation/*ethics
MH  - Liver Transplantation/ethics
MH  - Living Donors/*ethics/supply & distribution
MH  - Lung Transplantation/ethics
MH  - Medical Tourism/ethics
MH  - Tissue and Organ Procurement/*ethics
EDAT- 2012/06/27 06:00
MHDA- 2012/10/23 06:00
CRDT- 2012/06/27 06:00
PHST- 2012/03/06 00:00 [received]
PHST- 2012/05/03 00:00 [revised]
PHST- 2012/05/07 00:00 [accepted]
PHST- 2012/06/27 06:00 [entrez]
PHST- 2012/06/27 06:00 [pubmed]
PHST- 2012/10/23 06:00 [medline]
AID - S1548-5595(12)00106-1 [pii]
AID - 10.1053/j.ackd.2012.05.003 [doi]
PST - ppublish
SO  - Adv Chronic Kidney Dis. 2012 Jul;19(4):269-75. doi: 10.1053/j.ackd.2012.05.003.


PMID- 22732046
OWN - NLM
STAT- MEDLINE
DCOM- 20121022
LR  - 20120626
IS  - 1548-5609 (Electronic)
IS  - 1548-5595 (Linking)
VI  - 19
IP  - 4
DP  - 2012 Jul
TI  - Controversies in kidney paired donation.
PG  - 257-61
LID - 10.1053/j.ackd.2012.05.006 [doi]
AB  - Kidney paired donation represented 10% of living kidney donation in the United
      States in 2011. National registries around the world and several separate
      registries in the United States arrange paired donations, although with
      significant variations in their practices. Concerns about ethical considerations,
      clinical advisability, and the quantitative effectiveness of these approaches in 
      paired donation result in these variations. For instance, although donor travel
      can be burdensome and might discourage paired donation, it was nearly universal
      until convincing analysis showed that living donor kidneys can sustain many hours
      of cold ischemia time without adverse consequences. Opinions also differ about
      whether the last donor in a chain of paired donation transplants initiated by a
      nondirected donor should donate immediately to someone on the deceased donor
      wait-list (a domino or closed chain) or should be asked to wait some length of
      time and donate to start another sequence of paired donations later (an open
      chain); some argue that asking the donor to donate later may be coercive, and
      others focus on balancing the probability that the waiting donor withdraws versus
      the number of additional transplants if the chain can be continued. Other
      controversies in paired donation include simultaneous versus nonsimultaneous
      donor operations, whether to enroll compatible pairs, and interactions with
      desensitization protocols. Efforts to expand public awareness of and
      participation in paired donation are needed to generate more transplant
      opportunities.
CI  - Copyright (c) 2012 National Kidney Foundation, Inc. All rights reserved.
FAU - Gentry, Sommer E
AU  - Gentry SE
AD  - Department of Mathematics, United States Naval Academy, Annapolis, MD, USA.
FAU - Montgomery, Robert A
AU  - Montgomery RA
FAU - Segev, Dorry L
AU  - Segev DL
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Adv Chronic Kidney Dis
JT  - Advances in chronic kidney disease
JID - 101209214
SB  - IM
MH  - Blood Group Incompatibility
MH  - Desensitization, Immunologic
MH  - Humans
MH  - Kidney Transplantation/*ethics
MH  - Living Donors/*ethics
MH  - Tissue and Organ Procurement/*ethics/organization & administration
MH  - Waiting Lists
EDAT- 2012/06/27 06:00
MHDA- 2012/10/23 06:00
CRDT- 2012/06/27 06:00
PHST- 2012/04/27 00:00 [received]
PHST- 2012/05/09 00:00 [revised]
PHST- 2012/05/11 00:00 [accepted]
PHST- 2012/06/27 06:00 [entrez]
PHST- 2012/06/27 06:00 [pubmed]
PHST- 2012/10/23 06:00 [medline]
AID - S1548-5595(12)00113-9 [pii]
AID - 10.1053/j.ackd.2012.05.006 [doi]
PST - ppublish
SO  - Adv Chronic Kidney Dis. 2012 Jul;19(4):257-61. doi: 10.1053/j.ackd.2012.05.006.


PMID- 22731516
OWN - NLM
STAT- MEDLINE
DCOM- 20121226
LR  - 20211021
IS  - 1557-7740 (Electronic)
IS  - 1557-7740 (Linking)
VI  - 15
IP  - 8
DP  - 2012 Aug
TI  - Compassion and vigilance: investigators' strategies to manage ethical concerns in
      palliative and end-of-life research.
PG  - 880-9
LID - 10.1089/jpm.2011.0515 [doi]
AB  - BACKGROUND: Ethical concerns were identified as a potential barrier to advancing 
      palliative and end-of-life science at the 2004 National Institutes of Health
      State of the Science Meeting. However, data are lacking about the nature of
      ethical concerns and strategies for balancing the need to advance science with
      human subjects protections. METHODS: A qualitative case-study design was used to 
      follow 43 end-of-life studies from proposal development through the review
      process and implementation. Investigators participated in semi-structured
      telephone interviews and provided document data regarding their experiences with 
      grant and IRB reviews. Using constant comparative analysis within and across
      cases, the investigators identified commonly encountered and unique concerns and 
      strategies for managing these concerns. FINDINGS: Investigator strategies fell
      into two broad categories: 1) Recruitment and consent strategies related to
      subject identification and enrollment; and 2) Protocol-related strategies related
      to the process of data collection. These strategies shared the overarching
      meta-themes of compassion, as evidenced by a heightened sensitivity to the needs 
      of the population, coupled with vigilance, as evidenced by close attention to the
      possible effects of study participation on the participants' well-being, clinical
      care, and the needs of research staff. CONCLUSIONS: Ethical concerns have led to 
      the development of compassionate and vigilant strategies designed to balance the 
      potential for risk of harm with the need to advance the science of palliative and
      end-of-life care. These strategies can be used by investigators to address
      ethical concerns and minimize barriers to the development of palliative and
      end-of-life care science.
FAU - Hickman, Susan E
AU  - Hickman SE
AD  - Indiana University School of Nursing, 1111 Middle Drive, Indianapolis, IN 46202, 
      USA. hickman@iupui.edu
FAU - Cartwright, Juliana C
AU  - Cartwright JC
FAU - Nelson, Christine A
AU  - Nelson CA
FAU - Knafl, Kathleen
AU  - Knafl K
LA  - eng
GR  - R21 NR010397/NR/NINR NIH HHS/United States
GR  - NR010397/NR/NINR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20120625
PL  - United States
TA  - J Palliat Med
JT  - Journal of palliative medicine
JID - 9808462
SB  - IM
MH  - Attitude of Health Personnel
MH  - Empathy
MH  - Ethics, Research
MH  - Female
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Palliative Care/*ethics
MH  - Patient Selection/*ethics
MH  - Qualitative Research
MH  - Research Design
MH  - Research Personnel/*ethics/psychology
MH  - Terminal Care/*ethics
PMC - PMC3396150
EDAT- 2012/06/27 06:00
MHDA- 2012/12/27 06:00
CRDT- 2012/06/27 06:00
PHST- 2012/06/27 06:00 [entrez]
PHST- 2012/06/27 06:00 [pubmed]
PHST- 2012/12/27 06:00 [medline]
AID - 10.1089/jpm.2011.0515 [doi]
PST - ppublish
SO  - J Palliat Med. 2012 Aug;15(8):880-9. doi: 10.1089/jpm.2011.0515. Epub 2012 Jun
      25.


PMID- 22730937
OWN - NLM
STAT- MEDLINE
DCOM- 20120731
LR  - 20191112
IS  - 1036-1073 (Print)
IS  - 1036-1073 (Linking)
VI  - 23
IP  - 1
DP  - 2012 Apr
TI  - What is health promotion ethics?
PG  - 4
FAU - Carter, Stacy M
AU  - Carter SM
LA  - eng
PT  - Editorial
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Health Promot J Austr
JT  - Health promotion journal of Australia : official journal of Australian
      Association of Health Promotion Professionals
JID - 9710936
SB  - IM
MH  - Ethical Analysis
MH  - Health Promotion/*ethics
MH  - Humans
EDAT- 2012/06/27 06:00
MHDA- 2012/08/01 06:00
CRDT- 2012/06/27 06:00
PHST- 2012/06/27 06:00 [entrez]
PHST- 2012/06/27 06:00 [pubmed]
PHST- 2012/08/01 06:00 [medline]
AID - 10.1071/he12004 [doi]
PST - ppublish
SO  - Health Promot J Austr. 2012 Apr;23(1):4. doi: 10.1071/he12004.


PMID- 22730885
OWN - NLM
STAT- MEDLINE
DCOM- 20120814
LR  - 20120626
IS  - 0038-0814 (Print)
IS  - 0038-0814 (Linking)
IP  - 765
DP  - 2012 May
TI  - [Reconstructive surgery and face transplants, reconstruction or creation?].
PG  - 37-9
AB  - Twenty patients across the world have received a face transplant. A research
      protocol approved by the French national consultative committee of ethics in 2002
      has enabled 9 transplants to take place in France. After these operations, the
      technical and relational care provided to the transplant patients helps them
      reconstruct an image of themselves.
FAU - Mardoyan, Seta
AU  - Mardoyan S
AD  - Cadre de Sante, Service de Chirurgie Plastique Reconstructrice et Esthetique,
      Hopital Henri-Mondor, Creteil.
FAU - Pinelli, Nicole
AU  - Pinelli N
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - La chirurgie reparatrice et la greffe de visage, reconstruction ou creation?
PL  - France
TA  - Soins
JT  - Soins; la revue de reference infirmiere
JID - 20910580R
MH  - Facial Injuries/surgery
MH  - Facial Neoplasms/surgery
MH  - *Facial Transplantation/ethics/psychology
MH  - Humans
MH  - Neurofibromatoses/surgery
MH  - Postoperative Care
MH  - Preoperative Care
EDAT- 2012/06/27 06:00
MHDA- 2012/08/15 06:00
CRDT- 2012/06/27 06:00
PHST- 2012/06/27 06:00 [entrez]
PHST- 2012/06/27 06:00 [pubmed]
PHST- 2012/08/15 06:00 [medline]
PST - ppublish
SO  - Soins. 2012 May;(765):37-9.


PMID- 22730863
OWN - NLM
STAT- MEDLINE
DCOM- 20120725
LR  - 20220409
IS  - 0022-1058 (Print)
IS  - 0022-1058 (Linking)
VI  - 44
IP  - 1
DP  - 2012 Mar
TI  - Bloodless extracorporeal membrane oxygenation in the Jehovah's Witness patient.
PG  - 39-42
AB  - The successful use of prolonged extracorporeal life support with a heart-lung
      machine was first performed in 1972, as described by Hill et al., on a young man 
      with post-traumatic respiratory failure. The first successful use of
      extracorporeal membrane oxygenation (ECMO) was 1976 by Bartlett et al. Since this
      time, the use of ECMO for neonatal and pediatric pulmonary support has become a
      standard of care in many children's hospitals. The use of ECMO, being a very
      invasive procedure, is not without risk. In our experience, most patients require
      multiple transfusions of the different blood components (packed red blood cells, 
      plasma, platelets, and cryoprecipitate). Exposure to one or more blood products
      often occurs with connection to the ECMO circuit, as the circuit is generally
      primed with blood products or whole blood. Jehovah's Witnesses (JWs) are known
      best in the medical community for their refusal of blood products, even at the
      risk of death, which presents challenges for health care providers. This belief
      stems from the biblical passages that have been quoted as forbidding transfusion:
      Genesis 9:3-4, Leviticus 17:13-14, and Acts 15:19-21. This refusal of blood poses
      even greater challenges when treating the pediatric JW population. When a blood
      product is deemed medically necessary for the JW patient, the healthcare provider
      must either seek legal intervention, or support the patient's/family's wishes and
      associated outcome. This ethical dilemma may be further complicated in the
      setting of therapies, which may pose additional risks and potentially less clear 
      benefit such as with ECMO. Bloodless cardiac surgery with cardiopulmonary bypass 
      has been reported in the JW population in adults and pediatrics, including
      neonates. After a thorough search of the literature, no published report of a JW 
      patient being supported on ECMO without blood or blood component utilization was 
      identified. This case report will present our experience with multiple day,
      bloodless ECMO support of a 17-year-old male patient of the JW faith.
FAU - Preston, Thomas J
AU  - Preston TJ
AD  - The Department of Cardiovascular Perfusion, The Heart Center at Nationwide
      Children's Hospital, Columbus, Ohio 43205, USA.
      Thomas.Preston@NationwideChildrens.org
FAU - Olshove, Vincent F Jr
AU  - Olshove VF Jr
FAU - Chase, Margaret
AU  - Chase M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Extra Corpor Technol
JT  - The journal of extra-corporeal technology
JID - 0267637
MH  - Adolescent
MH  - *Bloodless Medical and Surgical Procedures
MH  - Extracorporeal Membrane Oxygenation/*instrumentation/*methods
MH  - Humans
MH  - *Jehovah's Witnesses
MH  - Male
PMC - PMC4557438
EDAT- 2012/06/27 06:00
MHDA- 2012/07/26 06:00
CRDT- 2012/06/27 06:00
PHST- 2012/06/27 06:00 [entrez]
PHST- 2012/06/27 06:00 [pubmed]
PHST- 2012/07/26 06:00 [medline]
PST - ppublish
SO  - J Extra Corpor Technol. 2012 Mar;44(1):39-42.


PMID- 22730610
OWN - NLM
STAT- MEDLINE
DCOM- 20120814
LR  - 20120626
IS  - 0995-3914 (Print)
IS  - 0995-3914 (Linking)
VI  - 24
IP  - 1
DP  - 2012 Jan-Feb
TI  - [Specialist and lay ethical expertise in public health: issues and challenges for
      discourse ethics].
PG  - 49-61
AB  - In recent decades, both public health professionals and the populations targeted 
      by prevention and health promotion programs have shown an increasing interest in 
      ethical issues since some interventions have been seen as impinging on
      fundamental rights and values. Insofar as bioethics is not adapted to population 
      interventions and community health issues, a specific expertise in public health 
      ethics is now required. However, ethical expertise in this area faces many
      challenges. The purpose of this paper is to examine four of these challenges. The
      first three challenges concern professional or specialist expertise. The paper
      suggests that expertise in public health ethics should go beyond the search for
      greater sophistication in defining ethical principles. Experts in public health
      ethics also need to identify appropriate strategies to include public health
      professionals in ethical analysis and to adopt a critical and reflexive approach 
      to the status of moral experts and moral expertise. However, the main challenge
      is to identify appropriate ways of reconciling lay and specialist ethical
      expertise. The paper argues that secular morality and common morality represent
      two key sources of lay ethics expertise and that the fundamental values that
      inform discourse ethics should be derived from both forms of expertise.
FAU - Masse, Raymond
AU  - Masse R
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Expertises ethiques savantes et profanes en sante publique: defis et enjeux pour 
      une ethique de la discussion.
PL  - France
TA  - Sante Publique
JT  - Sante publique (Vandoeuvre-les-Nancy, France)
JID - 9216153
SB  - IM
MH  - *Health Policy
MH  - Humans
MH  - *Professional Competence
MH  - Public Health/*ethics
MH  - Public Health Practice
EDAT- 2012/06/27 06:00
MHDA- 2012/08/15 06:00
CRDT- 2012/06/27 06:00
PHST- 2012/06/27 06:00 [entrez]
PHST- 2012/06/27 06:00 [pubmed]
PHST- 2012/08/15 06:00 [medline]
PST - ppublish
SO  - Sante Publique. 2012 Jan-Feb;24(1):49-61.


PMID- 22730459
OWN - NLM
STAT- MEDLINE
DCOM- 20121023
LR  - 20181201
IS  - 1468-3318 (Electronic)
IS  - 0964-4563 (Linking)
VI  - 21
IP  - 4
DP  - 2012 Jul
TI  - The ethics of studying subjects in non-ideal circumstances.
PG  - 385-6
LID - 10.1136/tobaccocontrol-2012-050620 [doi]
FAU - Wendler, David
AU  - Wendler D
LA  - eng
PT  - Editorial
PT  - Comment
PL  - England
TA  - Tob Control
JT  - Tobacco control
JID - 9209612
RN  - 0 (Tobacco Smoke Pollution)
SB  - IM
CON - Tob Control. 2012 Jul;21(4):392-5. PMID: 22246780
CON - Tob Control. 2012 Jul;21(4):383-4; discussion 384. PMID: 22730456
MH  - Female
MH  - Humans
MH  - Male
MH  - Sleep Bruxism/*etiology/*prevention & control
MH  - Tobacco Smoke Pollution/*adverse effects
EDAT- 2012/06/26 06:00
MHDA- 2012/10/24 06:00
CRDT- 2012/06/26 06:00
PHST- 2012/06/26 06:00 [entrez]
PHST- 2012/06/26 06:00 [pubmed]
PHST- 2012/10/24 06:00 [medline]
AID - tobaccocontrol-2012-050620 [pii]
AID - 10.1136/tobaccocontrol-2012-050620 [doi]
PST - ppublish
SO  - Tob Control. 2012 Jul;21(4):385-6. doi: 10.1136/tobaccocontrol-2012-050620.


PMID- 22730206
OWN - NLM
STAT- MEDLINE
DCOM- 20140306
LR  - 20130620
IS  - 1097-0347 (Electronic)
IS  - 1043-3074 (Linking)
VI  - 35
IP  - 7
DP  - 2013 Jul
TI  - Prognostic factors for supraglottic laryngeal carcinoma: Importance of the unfit 
      patient.
PG  - 949-58
LID - 10.1002/hed.23061 [doi]
AB  - BACKGROUND: The purpose of this study was to define prognostic factors for
      supraglottic laryngeal cancer that may influence management. METHODS: This
      ethics-approved study captured information on patients who presented with
      supraglottic laryngeal cancer between 1967 and 2008. Endpoints were
      local/ultimate failure and cancer-specific survival (CSS). Analysis was performed
      using chi-square, Fisher exact test, and logistic regression. Kaplan-Meier and
      Cox regression analysis were used to describe time-to-event data. RESULTS: Three 
      hundred sixty-nine patients were analyzed. Two hundred seventeen patients
      received radiotherapy, 30 were treated with surgery, and 122 were treated with
      radiotherapy and surgery. The 5-year ultimate local control and CSS rates were
      79.5% and 62.8%. Treatment type was a univariate predictor for outcome; however, 
      it was not an independent predictor for ultimate local control or CSS.
      CONCLUSIONS: This study highlights the fact that by documenting information it is
      possible to define prognostic factors. It also shows the importance of adjusting 
      for clinical predictors such as patients being unfit for surgery.
CI  - Copyright (c) 2012 Wiley Periodicals, Inc.
FAU - Smee, Robert I
AU  - Smee RI
AD  - Department of Radiation Oncology, The Prince of Wales Cancer Centre, Level 2,
      High St, Randwick, New South Wales, Australia.
FAU - De-loyde, Katie J
AU  - De-loyde KJ
FAU - Broadley, Kathryn
AU  - Broadley K
FAU - Williams, Janet R
AU  - Williams JR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120622
PL  - United States
TA  - Head Neck
JT  - Head & neck
JID - 8902541
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma in Situ/*diagnosis/mortality/therapy
MH  - Carcinoma, Squamous Cell/*diagnosis/mortality/therapy
MH  - Combined Modality Therapy
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Laryngeal Neoplasms/*diagnosis/mortality/therapy
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Regression Analysis
MH  - Retrospective Studies
MH  - Survival Rate
MH  - Treatment Outcome
EDAT- 2012/06/26 06:00
MHDA- 2014/03/07 06:00
CRDT- 2012/06/26 06:00
PHST- 2012/03/22 00:00 [accepted]
PHST- 2012/06/26 06:00 [entrez]
PHST- 2012/06/26 06:00 [pubmed]
PHST- 2014/03/07 06:00 [medline]
AID - 10.1002/hed.23061 [doi]
PST - ppublish
SO  - Head Neck. 2013 Jul;35(7):949-58. doi: 10.1002/hed.23061. Epub 2012 Jun 22.


PMID- 22729832
OWN - NLM
STAT- MEDLINE
DCOM- 20121211
LR  - 20161125
IS  - 1096-8652 (Electronic)
IS  - 0361-8609 (Linking)
VI  - 87
IP  - 10
DP  - 2012 Oct
TI  - Bleeding and mortality outcomes in ITP clinical trials: a review of
      thrombopoietin mimetics data.
PG  - 984-7
LID - 10.1002/ajh.23275 [doi]
AB  - Patients with ITP may have severe thrombocytopenia, putting them at risk for
      serious bleeding. ITP trials of new treatments must allow use of standard-of-care
      therapies to prevent serious bleeding. Thrombopoietin mimetic trials used
      platelet counts and rescue/concomitant medication use as endpoints. These trials 
      were of insufficient size and duration to measure mortality or serious bleeding, 
      which are infrequent with appropriate treatment. A recent Cochrane review
      criticized the thrombopoietin mimetic registrational trials for inadequately
      assessing bleeding and survival. We discuss how these endpoints are difficult to 
      measure in clinical trials designed to improve platelet counts and minimize
      bleeding, in accordance with ethical trial design.
CI  - Copyright (c) 2012 Wiley Periodicals, Inc.
FAU - Altomare, Ivy
AU  - Altomare I
AD  - Division of Hematology-Oncology, Duke University Medical Center, Durham, NC, USA.
      ivy.altomare@duke.edu
FAU - Wasser, Jeffrey
AU  - Wasser J
FAU - Pullarkat, Vinod
AU  - Pullarkat V
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120622
PL  - United States
TA  - Am J Hematol
JT  - American journal of hematology
JID - 7610369
RN  - 0 (Benzoates)
RN  - 0 (Hydrazines)
RN  - 0 (Pyrazoles)
RN  - 0 (Receptors, Fc)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 9014-42-0 (Thrombopoietin)
RN  - GN5XU2DXKV (romiplostim)
RN  - S56D65XJ9G (eltrombopag)
SB  - IM
CIN - Am J Hematol. 2012 Oct;87(10):945-6. PMID: 22847526
CIN - Am J Hematol. 2012 Oct;87(10):943. PMID: 22847599
CIN - Am J Hematol. 2012 Oct;87(10):943-4. PMID: 22987253
MH  - Benzoates/*therapeutic use
MH  - Clinical Trials as Topic/*statistics & numerical data
MH  - Hemorrhage/epidemiology/etiology/*prevention & control
MH  - Humans
MH  - Hydrazines/*therapeutic use
MH  - Incidence
MH  - Platelet Count
MH  - Proportional Hazards Models
MH  - Purpura, Thrombocytopenic, Idiopathic/complications/*drug therapy/mortality
MH  - Pyrazoles/*therapeutic use
MH  - Randomized Controlled Trials as Topic/*statistics & numerical data
MH  - Receptors, Fc/*therapeutic use
MH  - Recombinant Fusion Proteins/*therapeutic use
MH  - Research Design
MH  - Standard of Care
MH  - Thrombopoietin/*agonists/therapeutic use
MH  - Treatment Outcome
EDAT- 2012/06/26 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/06/26 06:00
PHST- 2012/02/03 00:00 [received]
PHST- 2012/04/20 00:00 [revised]
PHST- 2012/05/15 00:00 [accepted]
PHST- 2012/06/26 06:00 [entrez]
PHST- 2012/06/26 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - 10.1002/ajh.23275 [doi]
PST - ppublish
SO  - Am J Hematol. 2012 Oct;87(10):984-7. doi: 10.1002/ajh.23275. Epub 2012 Jun 22.


PMID- 22729653
OWN - NLM
STAT- MEDLINE
DCOM- 20140122
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 3
DP  - 2013 Sep
TI  - Ethical considerations for volunteer recruitment of visual prosthesis trials.
PG  - 1099-106
LID - 10.1007/s11948-012-9375-6 [doi]
AB  - With the development of visual prostheses research from the engineering phase to 
      clinical trials, volunteer recruitment for the early visual prosthesis trials
      needs to be carefully considered. In this article, we mainly discuss several
      issues related to volunteer recruitment that had posed serious challenges to the 
      visual prosthesis trials, such as low rates of participants, high expectations
      and underlying motivations to participate in the visual prosthesis trials as well
      as the importance of informed consent. When recruiting volunteers for visual
      prosthesis implants, it is critical that the visual prosthesis researchers should
      not only take into account the patient's expectations and motivations, but also
      make the patients fully aware of the possible benefits and risks involved with
      their participation, and help patients establish realistic expectations for the
      early phase of visual prosthesis implantation. Based on these considerations to
      the challenges, eligible volunteers may be recruited in the preliminary stages of
      visual prosthesis trials.
FAU - Xia, Yu
AU  - Xia Y
AD  - Department of Ophthalmology, PLA Navy General Hospital, Beijing, China.
      iamirisxy@163.com
FAU - Ren, Qiushi
AU  - Ren Q
LA  - eng
PT  - Journal Article
DEP - 20120623
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Clinical Trials as Topic/*ethics
MH  - *Human Experimentation
MH  - Humans
MH  - *Informed Consent
MH  - Patient Selection/*ethics
MH  - *Research Subjects
MH  - *Visual Prosthesis
MH  - Volunteers
EDAT- 2012/06/26 06:00
MHDA- 2014/01/23 06:00
CRDT- 2012/06/26 06:00
PHST- 2011/07/16 00:00 [received]
PHST- 2012/06/12 00:00 [accepted]
PHST- 2012/06/26 06:00 [entrez]
PHST- 2012/06/26 06:00 [pubmed]
PHST- 2014/01/23 06:00 [medline]
AID - 10.1007/s11948-012-9375-6 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Sep;19(3):1099-106. doi: 10.1007/s11948-012-9375-6. Epub
      2012 Jun 23.


PMID- 22729072
OWN - NLM
STAT- MEDLINE
DCOM- 20130522
LR  - 20120724
IS  - 1872-9738 (Electronic)
IS  - 0892-0362 (Linking)
VI  - 34
IP  - 4
DP  - 2012 Jul
TI  - The classification of motor neuron defects in the zebrafish embryo toxicity test 
      (ZFET) as an animal alternative approach to assess developmental neurotoxicity.
PG  - 413-24
LID - 10.1016/j.ntt.2012.04.006 [doi]
AB  - Rodents are widely used to test the developmental neurotoxicity potential of
      chemical substances. The regulatory test procedures are elaborate and the
      requirement of numerous animals is ethically disputable. Therefore, non-animal
      alternatives are highly desirable, but appropriate test systems that meet
      regulatory demands are not yet available. Hence, we have developed a new
      developmental neurotoxicity assay based on specific whole-mount immunostainings
      of primary and secondary motor neurons (using the monoclonal antibodies znp1 and 
      zn8) in zebrafish embryos. By classifying the motor neuron defects, we evaluated 
      the severity of the neurotoxic damage to individual primary and secondary motor
      neurons caused by chemical exposure and determined the corresponding effect
      concentration values (EC(5)(0)). In a proof-of-principle study, we investigated
      the effects of three model compounds thiocyclam, cartap and disulfiram, which
      show some neurotoxicity-indicating effects in vertebrates, and the positive
      controls ethanol and nicotine and the negative controls 3,4-dichloroaniline
      (3,4-DCA) and triclosan. As a quantitative measure of the neurotoxic potential of
      the test compounds, we calculated the ratios of the EC(5)(0) values for motor
      neuron defects and the cumulative malformations, as determined in a zebrafish
      embryo toxicity test (zFET). Based on this index, disulfiram was classified as
      the most potent and thiocyclam as the least potent developmental neurotoxin. The 
      index also confirmed the control compounds as positive and negative
      neurotoxicants. Our findings demonstrate that this index can be used to reliably 
      distinguish between neurotoxic and non-neurotoxic chemicals and provide a sound
      estimate for the neurodevelopmental hazard potential of a chemical. The
      demonstrated method can be a feasible approach to reduce the number of animals
      used in developmental neurotoxicity evaluation procedures.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Muth-Kohne, Elke
AU  - Muth-Kohne E
AD  - Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Aachen and
      Schmallenberg, Germany. elke.muth-koehne@ime.fraunhofer.de
FAU - Wichmann, Arne
AU  - Wichmann A
FAU - Delov, Vera
AU  - Delov V
FAU - Fenske, Martina
AU  - Fenske M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120424
PL  - United States
TA  - Neurotoxicol Teratol
JT  - Neurotoxicology and teratology
JID - 8709538
RN  - 0 (Neurotoxins)
SB  - IM
MH  - Animal Use Alternatives/*methods
MH  - Animals
MH  - Disease Models, Animal
MH  - Embryo, Nonmammalian/drug effects/embryology
MH  - Female
MH  - Male
MH  - Motor Neuron Disease/*chemically induced/*classification
MH  - Neurotoxicity Syndromes/classification
MH  - Neurotoxins/chemistry/*toxicity
MH  - Toxicity Tests/*methods
MH  - Zebrafish
EDAT- 2012/06/26 06:00
MHDA- 2013/05/23 06:00
CRDT- 2012/06/26 06:00
PHST- 2011/09/08 00:00 [received]
PHST- 2012/01/13 00:00 [revised]
PHST- 2012/04/10 00:00 [accepted]
PHST- 2012/06/26 06:00 [entrez]
PHST- 2012/06/26 06:00 [pubmed]
PHST- 2013/05/23 06:00 [medline]
AID - S0892-0362(12)00049-9 [pii]
AID - 10.1016/j.ntt.2012.04.006 [doi]
PST - ppublish
SO  - Neurotoxicol Teratol. 2012 Jul;34(4):413-24. doi: 10.1016/j.ntt.2012.04.006. Epub
      2012 Apr 24.


PMID- 22728294
OWN - NLM
STAT- MEDLINE
DCOM- 20120927
LR  - 20120723
IS  - 1534-6080 (Electronic)
IS  - 0041-1337 (Linking)
VI  - 94
IP  - 2
DP  - 2012 Jul 27
TI  - Evolution of the Transplantation of Human Organ Act and law in India.
PG  - 110-3
LID - 10.1097/TP.0b013e31825ace15 [doi]
AB  - : The Government of India has established laws to conduct organ transplantation
      in India. The Transplantation of Human Organ Act and rules in India were
      promulgated in 1994 and subsequently amended in 2008 and 2011 to promote organ
      transplantation, including deceased organ donation, commensurate with the highest
      ethical principles. We have reviewed in brief the origin and evolution of the
      Transplantation of Human Organ Act in India with the hope that our experience in 
      developing the laws that govern organ transplantation may be of value for others 
      undertaking or overseeing this life-giving advance.
FAU - Agarwal, Sanjay K
AU  - Agarwal SK
AD  - Department of Nephrology, All India Institute of Medical Sciences, New Delhi,
      India. skagarwalnephro@gmail.com
FAU - Srivastava, Rakesh K
AU  - Srivastava RK
FAU - Gupta, Sudhir
AU  - Gupta S
FAU - Tripathi, Samidha
AU  - Tripathi S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
SB  - IM
MH  - Brain Death/diagnosis
MH  - Humans
MH  - India
MH  - Organ Transplantation/*legislation & jurisprudence
MH  - Time Factors
MH  - Tissue and Organ Procurement/legislation & jurisprudence
EDAT- 2012/06/26 06:00
MHDA- 2012/09/28 06:00
CRDT- 2012/06/26 06:00
PHST- 2012/06/26 06:00 [entrez]
PHST- 2012/06/26 06:00 [pubmed]
PHST- 2012/09/28 06:00 [medline]
AID - 10.1097/TP.0b013e31825ace15 [doi]
PST - ppublish
SO  - Transplantation. 2012 Jul 27;94(2):110-3. doi: 10.1097/TP.0b013e31825ace15.


PMID- 22728231
OWN - NLM
STAT- MEDLINE
DCOM- 20130918
LR  - 20141120
IS  - 1879-3177 (Electronic)
IS  - 0887-2333 (Linking)
VI  - 27
IP  - 3
DP  - 2013 Apr
TI  - Transfer of a two-tiered keratinocyte assay: IL-18 production by NCTC2544 to
      determine the skin sensitizing capacity and epidermal equivalent assay to
      determine sensitizer potency.
PG  - 1135-50
LID - 10.1016/j.tiv.2012.06.004 [doi]
LID - S0887-2333(12)00154-3 [pii]
AB  - At present, the identification of potentially sensitizing chemicals is carried
      out using animal models. However, it is very important from ethical, safety and
      economic point of view to have biological markers to discriminate allergy and
      irritation events, and to be able to classify sensitizers according to their
      potency, without the use of animals. Within the Sens-it-iv EU Frame Programme 6
      funded Integrated Project (LSHB-CT-2005-018681), a number of in vitro, human cell
      based assays were developed which, when optimized and used in an integrated
      testing strategy, may be able to distinguish sensitizers from non-sensitizers.
      This study describes two of these assays, which when used in a tiered strategy,
      may be able to identify contact sensitizers and also to quantify sensitizer
      potency. Tier 1 is the human keratinocyte NCTC2544 IL-18 assay and tier 2 is the 
      Epidermal Equivalent potency assay. The aim of this study is to show the
      transferability of the two-tiered approach with training chemicals: 3 sensitizers
      (DNCB, resorcinol, pPD) and 1 non sensitizer (lactic acid) in tier 1 and 2
      sensitizers with different potency in tier 2 (DNCB; extreme and resorcinol;
      moderate). The chemicals were tested in a non-coded fashion. Here we describe the
      transferability to naive laboratories, the establishment of the standard
      operating procedure, critical points, acceptance criteria and project management.
      Both assays were successfully transferred to laboratories that had not performed 
      the assays previously. The two tiered approach may offer an unique opportunity to
      provide an alternative method to the Local Lymph Node Assay (LLNA). These assays 
      are both based on the use of human keratinocytes, which have been shown over the 
      last two decades, to play a key role in all phases of skin sensitization.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Teunis, Marc
AU  - Teunis M
AD  - University of Applied Sciences, Utrecht, The Netherlands. marc.teunis@hu.nl
FAU - Corsini, Emanuela
AU  - Corsini E
FAU - Smits, Mieke
AU  - Smits M
FAU - Madsen, Charlotte Bernhard
AU  - Madsen CB
FAU - Eltze, Tobias
AU  - Eltze T
FAU - Ezendam, Janine
AU  - Ezendam J
FAU - Galbiati, Valentina
AU  - Galbiati V
FAU - Gremmer, Eric
AU  - Gremmer E
FAU - Krul, Cyrille
AU  - Krul C
FAU - Landin, Annette
AU  - Landin A
FAU - Landsiedel, Robert
AU  - Landsiedel R
FAU - Pieters, Raymond
AU  - Pieters R
FAU - Rasmussen, Tina Frid
AU  - Rasmussen TF
FAU - Reinders, Judith
AU  - Reinders J
FAU - Roggen, Erwin
AU  - Roggen E
FAU - Spiekstra, Sander
AU  - Spiekstra S
FAU - Gibbs, Susan
AU  - Gibbs S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120619
PL  - England
TA  - Toxicol In Vitro
JT  - Toxicology in vitro : an international journal published in association with
      BIBRA
JID - 8712158
RN  - 0 (Allergens)
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Allergens/*toxicity
MH  - *Biological Assay
MH  - Cell Line
MH  - Cell Survival
MH  - Dermatitis, Allergic Contact/etiology
MH  - Humans
MH  - In Vitro Techniques
MH  - Interleukin-18/*metabolism
MH  - Keratinocytes/*drug effects/metabolism
MH  - Reproducibility of Results
EDAT- 2012/06/26 06:00
MHDA- 2013/09/21 06:00
CRDT- 2012/06/26 06:00
PHST- 2012/01/18 00:00 [received]
PHST- 2012/05/31 00:00 [revised]
PHST- 2012/06/13 00:00 [accepted]
PHST- 2012/06/26 06:00 [entrez]
PHST- 2012/06/26 06:00 [pubmed]
PHST- 2013/09/21 06:00 [medline]
AID - S0887-2333(12)00154-3 [pii]
AID - 10.1016/j.tiv.2012.06.004 [doi]
PST - ppublish
SO  - Toxicol In Vitro. 2013 Apr;27(3):1135-50. doi: 10.1016/j.tiv.2012.06.004. Epub
      2012 Jun 19.


PMID- 22728219
OWN - NLM
STAT- MEDLINE
DCOM- 20140203
LR  - 20211021
IS  - 1873-2518 (Electronic)
IS  - 0264-410X (Linking)
VI  - 31
IP  - 21
DP  - 2013 May 17
TI  - Human immune responses to vaccines in the first year of life: biological,
      socio-economic and ethical issues - a viewpoint.
PG  - 2483-8
LID - 10.1016/j.vaccine.2012.06.018 [doi]
LID - S0264-410X(12)00859-6 [pii]
AB  - Human newborns are vulnerable to infectious diseases that account for majority of
      the morbidity and mortality, particularly in first year of life. Vaccines have
      become the most effective public health intervention strategy to curtail the
      prevalence of these infectious diseases. Although vaccines against a number of
      diseases exist, there are no vaccines against many other diseases that commonly
      affect children. The adequate assessment of immune responses to vaccines is an
      important step in the development of vaccines. However, a number of biological
      and "non-medical" socio-economic and ethical factors could influence either the
      administration and/or evaluation of vaccines in infants. Recognition and
      understanding of these determinants are crucial in planning interventions and for
      logical interpretations of results.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Ota, M O C
AU  - Ota MO
AD  - Vaccinology Theme, Medical Research Council MRC Unit, Banjul, Gambia. mota@mrc.gm
FAU - Idoko, O T
AU  - Idoko OT
FAU - Ogundare, E O
AU  - Ogundare EO
FAU - Afolabi, M O
AU  - Afolabi MO
LA  - eng
GR  - MC_EX_MR/K011944/1/MRC_/Medical Research Council/United Kingdom
GR  - MC_U190071468/MRC_/Medical Research Council/United Kingdom
GR  - MC_UP_A900_1122/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Review
DEP - 20120619
PL  - Netherlands
TA  - Vaccine
JT  - Vaccine
JID - 8406899
RN  - 0 (Vaccines)
SB  - IM
MH  - Developing Countries
MH  - Female
MH  - Humans
MH  - Immunization Programs/*economics/*ethics
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Public Health
MH  - Socioeconomic Factors
MH  - Vaccines/*administration & dosage/economics/*immunology
EDAT- 2012/06/26 06:00
MHDA- 2014/02/04 06:00
CRDT- 2012/06/26 06:00
PHST- 2011/12/13 00:00 [received]
PHST- 2012/05/08 00:00 [revised]
PHST- 2012/06/06 00:00 [accepted]
PHST- 2012/06/26 06:00 [entrez]
PHST- 2012/06/26 06:00 [pubmed]
PHST- 2014/02/04 06:00 [medline]
AID - S0264-410X(12)00859-6 [pii]
AID - 10.1016/j.vaccine.2012.06.018 [doi]
PST - ppublish
SO  - Vaccine. 2013 May 17;31(21):2483-8. doi: 10.1016/j.vaccine.2012.06.018. Epub 2012
      Jun 19.


PMID- 22727914
OWN - NLM
STAT- MEDLINE
DCOM- 20121130
LR  - 20161209
IS  - 2213-0276 (Electronic)
IS  - 0755-4982 (Linking)
VI  - 41
IP  - 9 Pt 1
DP  - 2012 Sep
TI  - The Committee on Publication Ethics (COPE): Objectives and achievements
      1997-2012.
PG  - 861-6
LID - 10.1016/j.lpm.2012.02.049 [doi]
AB  - Committee on Publication Ethics (COPE) was founded in 1997 by a small number of
      UK medical editors as a self-help group to discuss troubling ethical cases. COPE 
      now has over 7000 members working in many disciplines from all parts of the
      world. COPE members may bring anonymised cases to a quarterly Forum where other
      members offer advice. The COPE cases form the basis for guidance such as the
      flowcharts, which have proved popular and been translated into several languages.
      COPE expects its members to follow its Code of Conduct and will hear complaints
      that members have broken this code. Apart from complaints against members, COPE
      does not investigate individual cases but exists to provide advice on publication
      ethics and promote good practice among journal editors and publishers. Most of
      COPE's guidance is freely available to the public at www.publicationethics.org.
CI  - Copyright (c) 2012 Elsevier Masson SAS. All rights reserved.
FAU - Wager, Elizabeth
AU  - Wager E
AD  - Publications Consultant, Sideview, Station Road, Princes Risborough, HP27 9DE,
      United Kingdom. liz@sideview.demon.co.uk
LA  - eng
PT  - Journal Article
DEP - 20120622
PL  - France
TA  - Presse Med
JT  - Presse medicale (Paris, France : 1983)
JID - 8302490
SB  - IM
MH  - Advisory Committees
MH  - Decision Trees
MH  - Editorial Policies
MH  - Education, Distance
MH  - *Ethics Committees/organization & administration
MH  - Ethics, Research/education
MH  - Financial Support
MH  - Governing Board
MH  - Humans
MH  - International Cooperation
MH  - Periodicals as Topic
MH  - Practice Guidelines as Topic
MH  - Publishing/*ethics/organization & administration
MH  - Quality Control
MH  - *Scientific Misconduct
MH  - United Kingdom
EDAT- 2012/06/26 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/06/26 06:00
PHST- 2012/02/23 00:00 [received]
PHST- 2012/02/29 00:00 [accepted]
PHST- 2012/06/26 06:00 [entrez]
PHST- 2012/06/26 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - S0755-4982(12)00287-4 [pii]
AID - 10.1016/j.lpm.2012.02.049 [doi]
PST - ppublish
SO  - Presse Med. 2012 Sep;41(9 Pt 1):861-6. doi: 10.1016/j.lpm.2012.02.049. Epub 2012 
      Jun 22.


PMID- 22727581
OWN - NLM
STAT- MEDLINE
DCOM- 20140403
LR  - 20220317
IS  - 1532-2793 (Electronic)
IS  - 0260-6917 (Linking)
VI  - 33
IP  - 5
DP  - 2013 May
TI  - Development and psychometric evaluation of the competency inventory for nursing
      students: a learning outcome perspective.
PG  - 492-7
LID - 10.1016/j.nedt.2012.05.028 [doi]
LID - S0260-6917(12)00182-7 [pii]
AB  - Deficiency in essential core competencies could jeopardize the safety of
      patients. Adopting the outcome-based approach, a set of minimally required core
      competencies for nursing students was developed to ensure the quality of nursing 
      education. Determination of what point to measure competency is needed. Most
      importantly, competence indicators of nursing students can be used in curriculum 
      development, planning, and learning outcome evaluation. The purpose of this study
      was to develop a competency inventory to measure learning outcomes of
      baccalaureate nursing students and to test its psychometric properties.
      Psychometric testing was conducted with a convenience sample of 599 nursing
      students in 2011. Principal axis factor analysis was performed on the 52-item
      scale to determine construct validity and Cronbach's alpha was used to measure
      the internal consistency. Principal axis factoring method identified six factors 
      through the direct oblimin rotations including pattern matrix and structure
      matrix: ethical and responsibility, general clinical skills, lifelong learning,
      clinical biomedical science, caring and critical thinking reasoning. Exploratory 
      factor analysis yielded an instrument with 43-items on six factors, accounting
      for 69.84% of the variance in scores. The Competency Inventory of Nursing
      Students (CINS) factors ranged from 0.91 to 0.98. This study shows that the
      Competency Inventory of Nursing Students has satisfactory psychometric properties
      and could be a useful instrument for measuring learning outcomes of nursing
      student. The competence indicators show merit for assessing learning outcomes for
      nursing students in nursing education. However, a cross-validation of the scale
      with another sample is also needed.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Hsu, Li-Ling
AU  - Hsu LL
AD  - Graduate Institute of Health Allied Education, National Taipei University of
      Nursing and Health Sciences, No. 365, Ming-Te Rd., Peitou, Taipei City 11219,
      Taiwan, ROC. llhsu@ntunhs.edu.tw
FAU - Hsieh, Suh-Ing
AU  - Hsieh SI
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20120621
PL  - Scotland
TA  - Nurse Educ Today
JT  - Nurse education today
JID - 8511379
MH  - Adult
MH  - *Clinical Competence
MH  - Cross-Sectional Studies
MH  - *Education, Nursing, Baccalaureate
MH  - *Educational Measurement
MH  - Factor Analysis, Statistical
MH  - Female
MH  - Humans
MH  - Male
MH  - Psychometrics
MH  - Reproducibility of Results
MH  - Students, Nursing
MH  - Taiwan
MH  - Young Adult
EDAT- 2012/06/26 06:00
MHDA- 2014/04/04 06:00
CRDT- 2012/06/26 06:00
PHST- 2012/02/18 00:00 [received]
PHST- 2012/05/09 00:00 [revised]
PHST- 2012/05/31 00:00 [accepted]
PHST- 2012/06/26 06:00 [entrez]
PHST- 2012/06/26 06:00 [pubmed]
PHST- 2014/04/04 06:00 [medline]
AID - S0260-6917(12)00182-7 [pii]
AID - 10.1016/j.nedt.2012.05.028 [doi]
PST - ppublish
SO  - Nurse Educ Today. 2013 May;33(5):492-7. doi: 10.1016/j.nedt.2012.05.028. Epub
      2012 Jun 21.


PMID- 22727283
OWN - NLM
STAT- MEDLINE
DCOM- 20120927
LR  - 20120625
IS  - 1873-4502 (Electronic)
IS  - 0886-3350 (Linking)
VI  - 38
IP  - 7
DP  - 2012 Jul
TI  - Outcomes of air descemetopexy for Descemet membrane detachment after cataract
      surgery.
PG  - 1134-9
LID - 10.1016/j.jcrs.2012.01.030 [doi]
AB  - PURPOSE: To analyze the outcomes of post-cataract surgery descemetopexy for
      Descemet membrane detachment using intracameral air injection. SETTING: Cornea
      Department, LV Prasad Eye Institute, Hyderabad, India. DESIGN: Interventional
      case series. METHODS: The clinical data of patients who had descemetopexy from
      August 2010 to February 2011 for Descemet membrane detachment after cataract
      surgery using intracameral (100%) air injection were reviewed after institutional
      review board and ethics committee approval was obtained. RESULTS: Of the 14
      patients, 9 had manual small-incision cataract surgery using the Blumenthal and
      Moisseiev technique, 4 had phacoemulsification, and 1 had combined
      phacoemulsification with trabeculectomy. The mean duration between cataract
      surgery and descemetopexy was 19.5 days (range 2 to 49 days). Successful
      reattachment of Descemet membrane and resolution of corneal edema occurred in all
      except 1 patient. Two patients had elevated intraocular pressure 1 day
      postoperatively due to appositional angle closure in 1 and pupillary block in the
      other. Of the 13 patients with successful Descemet membrane reattachment, the
      corrected distance visual acuity was 20/40 or better in 11 cases, 20/80 in 1
      case, and 20/160 in 1 case. Three of the 13 patients had comorbidity factors
      affecting vision. CONCLUSION: Air descemetopexy was a safe option in the
      management of Descemet detachment after cataract surgery. FINANCIAL DISCLOSURE:
      No author has a financial or proprietary interest in any material or method
      mentioned.
CI  - Copyright (c) 2012 ASCRS and ESCRS. Published by Elsevier Inc. All rights
      reserved.
FAU - Chaurasia, Sunita
AU  - Chaurasia S
AD  - Cornea and Anterior Segment Services, LV Prasad Eye Institute, Kallam Anji Reddy 
      Campus, Hyderabad, India. sunita@lvpei.org
FAU - Ramappa, Muralidhar
AU  - Ramappa M
FAU - Garg, Prashant
AU  - Garg P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Cataract Refract Surg
JT  - Journal of cataract and refractive surgery
JID - 8604171
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Air
MH  - Anterior Chamber/surgery
MH  - Cataract Extraction/*adverse effects
MH  - Corneal Diseases/etiology/*surgery
MH  - Descemet Membrane/pathology/*surgery
MH  - Endotamponade/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Ophthalmologic Surgical Procedures
MH  - Retrospective Studies
MH  - Rupture, Spontaneous
MH  - Treatment Outcome
MH  - Visual Acuity/physiology
EDAT- 2012/06/26 06:00
MHDA- 2012/09/28 06:00
CRDT- 2012/06/26 06:00
PHST- 2011/10/22 00:00 [received]
PHST- 2012/01/19 00:00 [revised]
PHST- 2012/01/21 00:00 [accepted]
PHST- 2012/06/26 06:00 [entrez]
PHST- 2012/06/26 06:00 [pubmed]
PHST- 2012/09/28 06:00 [medline]
AID - S0886-3350(12)00471-3 [pii]
AID - 10.1016/j.jcrs.2012.01.030 [doi]
PST - ppublish
SO  - J Cataract Refract Surg. 2012 Jul;38(7):1134-9. doi: 10.1016/j.jcrs.2012.01.030.


PMID- 22726821
OWN - NLM
STAT- MEDLINE
DCOM- 20130422
LR  - 20220331
IS  - 1748-5908 (Electronic)
IS  - 1748-5908 (Linking)
VI  - 7
DP  - 2012 Jun 22
TI  - Understanding the performance and impact of public knowledge translation funding 
      interventions: protocol for an evaluation of Canadian Institutes of Health
      Research knowledge translation funding programs.
PG  - 57
LID - 10.1186/1748-5908-7-57 [doi]
AB  - BACKGROUND: The Canadian Institutes of Health Research (CIHR) has defined
      knowledge translation (KT) as a dynamic and iterative process that includes the
      synthesis, dissemination, exchange, and ethically-sound application of knowledge 
      to improve the health of Canadians, provide more effective health services and
      products, and strengthen the healthcare system. CIHR, the national health
      research funding agency in Canada, has undertaken to advance this concept through
      direct research funding opportunities in KT. Because CIHR is recognized within
      Canada and internationally for leading and funding the advancement of KT science 
      and practice, it is essential and timely to evaluate this intervention, and
      specifically, these funding opportunities. DESIGN: The study will employ a novel 
      method of participatory, utilization-focused evaluation inspired by the
      principles of integrated KT. It will use a mixed methods approach, drawing on
      both quantitative and qualitative data, and will elicit participation from CIHR
      funded researchers, knowledge users, KT experts, as well as other health research
      funding agencies. Lines of inquiry will include an international environmental
      scan, document/data reviews, in-depth interviews, targeted surveys, case studies,
      and an expert review panel. The study will investigate how efficiently and
      effectively the CIHR model of KT funding programs operates, what immediate
      outcomes these funding mechanisms have produced, and what impact these programs
      have had on the broader state of health research, health research uptake, and
      health improvement. DISCUSSION: The protocol and results of this evaluation will 
      be of interest to those engaged in the theory, practice, and evaluation of KT.
      The dissemination of the study protocol and results to both practitioners and
      theorists will help to fill a gap in knowledge in three areas: the role of a
      public research funding agency in facilitating KT, the outcomes and impacts KT
      funding interventions, and how KT can best be evaluated.
FAU - McLean, Robert K D
AU  - McLean RK
AD  - Evaluation Unit, Canadian Institutes of Health Research, 160 Elgin Street,
      Ottawa, ON, Canada. robert.mclean@cihr-irsc.gc.ca
FAU - Graham, Ian D
AU  - Graham ID
FAU - Bosompra, Kwadwo
AU  - Bosompra K
FAU - Choudhry, Yumna
AU  - Choudhry Y
FAU - Coen, Stephanie E
AU  - Coen SE
FAU - Macleod, Martha
AU  - Macleod M
FAU - Manuel, Christopher
AU  - Manuel C
FAU - McCarthy, Ryan
AU  - McCarthy R
FAU - Mota, Adrian
AU  - Mota A
FAU - Peckham, David
AU  - Peckham D
FAU - Tetroe, Jacqueline M
AU  - Tetroe JM
FAU - Tucker, Joanne
AU  - Tucker J
LA  - eng
PT  - Journal Article
DEP - 20120622
PL  - England
TA  - Implement Sci
JT  - Implementation science : IS
JID - 101258411
SB  - IM
MH  - Canada
MH  - Government Agencies/*economics
MH  - Health Education/economics/*organization & administration
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - *Information Dissemination
PMC - PMC3485627
EDAT- 2012/06/26 06:00
MHDA- 2013/04/23 06:00
CRDT- 2012/06/26 06:00
PHST- 2012/03/13 00:00 [received]
PHST- 2012/06/05 00:00 [accepted]
PHST- 2012/06/26 06:00 [entrez]
PHST- 2012/06/26 06:00 [pubmed]
PHST- 2013/04/23 06:00 [medline]
AID - 1748-5908-7-57 [pii]
AID - 10.1186/1748-5908-7-57 [doi]
PST - epublish
SO  - Implement Sci. 2012 Jun 22;7:57. doi: 10.1186/1748-5908-7-57.


PMID- 22726674
OWN - NLM
STAT- MEDLINE
DCOM- 20121217
LR  - 20151119
IS  - 1769-6682 (Electronic)
IS  - 1297-9589 (Linking)
VI  - 40
IP  - 7-8
DP  - 2012 Jul-Aug
TI  - [Female cosmetic genital surgery: point-counterpoint].
PG  - 445-8
LID - 10.1016/j.gyobfe.2012.05.014 [doi]
AB  - Cosmetic genitoplasty interventions, and especially reduction nymphoplasties, now
      seem to attract more and more patients, mainly among the younger who are more
      influenced by widely publicized pornographic than by anatomic reality they hardly
      suspect. However, they must be informed and warned against the trivialization of 
      a still young surgery, insufficiently justified validated and supervised,
      especially on the psychological level, and with many unresolved ethical issues.
CI  - Copyright (c) 2012 Elsevier Masson SAS. All rights reserved.
FAU - Colson, M-H
AU  - Colson MH
AD  - CRIR-AVS, hopital Sainte-Marguerite, 270 boulevard de Sainte-Marguerite,
      Marseille, France. marie.helene@colson.fr
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Que penser de la genitoplastie cosmetique feminine aujourd'hui ?
DEP - 20120620
PL  - France
TA  - Gynecol Obstet Fertil
JT  - Gynecologie, obstetrique & fertilite
JID - 100936305
SB  - IM
MH  - Body Image
MH  - Female
MH  - Gynecologic Surgical Procedures/ethics/*psychology
MH  - Humans
MH  - Patient Satisfaction
MH  - Surgery, Plastic/ethics/*psychology
MH  - Surveys and Questionnaires
EDAT- 2012/06/26 06:00
MHDA- 2012/12/18 06:00
CRDT- 2012/06/26 06:00
PHST- 2012/01/23 00:00 [received]
PHST- 2012/04/17 00:00 [accepted]
PHST- 2012/06/26 06:00 [entrez]
PHST- 2012/06/26 06:00 [pubmed]
PHST- 2012/12/18 06:00 [medline]
AID - S1297-9589(12)00166-X [pii]
AID - 10.1016/j.gyobfe.2012.05.014 [doi]
PST - ppublish
SO  - Gynecol Obstet Fertil. 2012 Jul-Aug;40(7-8):445-8. doi:
      10.1016/j.gyobfe.2012.05.014. Epub 2012 Jun 20.


PMID- 22726531
OWN - NLM
STAT- MEDLINE
DCOM- 20121001
LR  - 20220311
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 13
DP  - 2012 Jun 22
TI  - Benefits and payments for research participants: experiences and views from a
      research centre on the Kenyan coast.
PG  - 13
LID - 10.1186/1472-6939-13-13 [doi]
AB  - BACKGROUND: There is general consensus internationally that unfair distribution
      of the benefits of research is exploitative and should be avoided or reduced.
      However, what constitutes fair benefits, and the exact nature of the benefits and
      their mode of provision can be strongly contested. Empirical studies have the
      potential to contribute viewpoints and experiences to debates and guidelines, but
      few have been conducted. We conducted a study to support the development of
      guidelines on benefits and payments for studies conducted by the KEMRI-Wellcome
      Trust programme in Kilifi, Kenya. METHODS: Following an initial broad based
      survey of cash, health services and other items being offered during research by 
      all programme studies (n = 38 studies), interviews were held with research
      managers (n = 9), and with research staff involved in 8 purposively selected case
      studies (n = 30 interviewees). Interviews explored how these 'benefits' were
      selected and communicated, experiences with their administration, and
      recommendations for future guidelines. Data fed into a consultative workshop
      attended by 48 research staff and health managers, which was facilitated by an
      external ethicist. FINDINGS: The most commonly provided benefits were medical
      care (for example free care, and strengthened quality of care), and lunch or
      snacks. Most cash given to participants was reimbursement of transport costs (for
      example to meet appointments or facilitate use of services when unexpectedly
      sick), but these payments were often described by research participants as
      benefits. Challenges included: tensions within households and communities
      resulting from lack of clarity and agreement on who is eligible for benefits;
      suspicion regarding motivation for their provision; and confusion caused by
      differences between studies in types and levels of benefits. CONCLUSIONS:
      Research staff differed in their views on how benefits should be approached.
      Echoing elements of international benefit sharing and ancillary care debates,
      some research staff saw research as based on goodwill and partnership, and aimed 
      to avoid costs to participants and a commercial relationship; while others sought
      to maximise participant benefits given the relative wealth of the institution and
      the multiple community needs. An emerging middle position was to strengthen
      collateral or indirect medical benefits to communities through collaborations
      with the Ministry of Health to support sustainability.
FAU - Molyneux, Sassy
AU  - Molyneux S
AD  - Health Systems and Social Science Research Group, Kenya Medical Research
      Institute/Wellcome Trust Research Programme, Kilifi, Kenya.
      SMolyneux@kemri-wellcome.org
FAU - Mulupi, Stephen
AU  - Mulupi S
FAU - Mbaabu, Lairumbi
AU  - Mbaabu L
FAU - Marsh, Vicki
AU  - Marsh V
LA  - eng
GR  - 096527/WT_/Wellcome Trust/United Kingdom
GR  - GR074314MA/WT_/Wellcome Trust/United Kingdom
GR  - WT085418/WT_/Wellcome Trust/United Kingdom
GR  - 089316/Z/09/Z/WT_/Wellcome Trust/United Kingdom
GR  - 092654/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120622
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Employment/*economics
MH  - *Food
MH  - Guidelines as Topic
MH  - *Health Services Accessibility
MH  - Health Services Needs and Demand
MH  - Humans
MH  - Kenya
MH  - Research Subjects/*economics
MH  - Surveys and Questionnaires
PMC - PMC3407030
EDAT- 2012/06/26 06:00
MHDA- 2012/10/02 06:00
CRDT- 2012/06/26 06:00
PHST- 2012/01/21 00:00 [received]
PHST- 2012/06/22 00:00 [accepted]
PHST- 2012/06/26 06:00 [entrez]
PHST- 2012/06/26 06:00 [pubmed]
PHST- 2012/10/02 06:00 [medline]
AID - 1472-6939-13-13 [pii]
AID - 10.1186/1472-6939-13-13 [doi]
PST - epublish
SO  - BMC Med Ethics. 2012 Jun 22;13:13. doi: 10.1186/1472-6939-13-13.


PMID- 22726500
OWN - NLM
STAT- MEDLINE
DCOM- 20120719
LR  - 20150616
IS  - 1474-547X (Electronic)
IS  - 0140-6736 (Linking)
VI  - 379
IP  - 9834
DP  - 2012 Jun 23
TI  - Ethics of mitochondrial donation.
PG  - 2314
LID - 10.1016/S0140-6736(12)60999-4 [doi]
LA  - eng
PT  - Editorial
PL  - England
TA  - Lancet
JT  - Lancet (London, England)
JID - 2985213R
RN  - 0 (DNA, Mitochondrial)
SB  - IM
MH  - DNA, Mitochondrial/genetics
MH  - Ethics, Medical
MH  - Female
MH  - Fertilization in Vitro/ethics/methods
MH  - Humans
MH  - Mitochondria/*transplantation
MH  - Mitochondrial Diseases/*therapy
MH  - Oocyte Donation/*ethics/methods
EDAT- 2012/06/26 06:00
MHDA- 2012/07/20 06:00
CRDT- 2012/06/26 06:00
PHST- 2012/06/26 06:00 [entrez]
PHST- 2012/06/26 06:00 [pubmed]
PHST- 2012/07/20 06:00 [medline]
AID - S0140-6736(12)60999-4 [pii]
AID - 10.1016/S0140-6736(12)60999-4 [doi]
PST - ppublish
SO  - Lancet. 2012 Jun 23;379(9834):2314. doi: 10.1016/S0140-6736(12)60999-4.


PMID- 22726276
OWN - NLM
STAT- MEDLINE
DCOM- 20130208
LR  - 20211021
IS  - 1471-2288 (Electronic)
IS  - 1471-2288 (Linking)
VI  - 12
DP  - 2012 Jun 22
TI  - When is it rational to participate in a clinical trial? A game theory approach
      incorporating trust, regret and guilt.
PG  - 85
LID - 10.1186/1471-2288-12-85 [doi]
AB  - BACKGROUND: Randomized controlled trials (RCTs) remain an indispensable form of
      human experimentation as a vehicle for discovery of new treatments. However,
      since their inception RCTs have raised ethical concerns. The ethical tension has 
      revolved around "duties to individuals" vs. "societal value" of RCTs. By asking
      current patients "to sacrifice for the benefit of future patients" we risk
      subjugating our duties to patients' best interest to the utilitarian goal for the
      good of others. This tension creates a key dilemma: when is it rational, from the
      perspective of the trial patients and researchers (as societal representatives of
      future patients), to enroll in RCTs? METHODS: We employed the trust version of
      the prisoner's dilemma since interaction between the patient and researcher in
      the setting of a clinical trial is inherently based on trust. We also took into
      account that the patient may have regretted his/her decision to participate in
      the trial, while a researcher may feel guilty because he/she abused the patient's
      trust. RESULTS: We found that under typical circumstances of clinical research,
      most patients can be expected not to trust researchers, and most researchers can 
      be expected to abuse the patients' trust. The most significant factor determining
      trust was the success of experimental or standard treatments, respectively. The
      more that a researcher believes the experimental treatment will be successful,
      the more incentive the researcher has to abuse trust. The analysis was sensitive 
      to the assumptions about the utilities related to success and failure of
      therapies that are tested in RCTs. By varying all variables in the Monte Carlo
      analysis we found that, on average, the researcher can be expected to honor a
      patient's trust 41% of the time, while the patient is inclined to trust the
      researcher 69% of the time. Under assumptions of our model, enrollment into RCTs 
      represents a rational strategy that can meet both patients' and researchers'
      interests simultaneously 19% of the time. CONCLUSIONS: There is an inherent
      ethical dilemma in the conduct of RCTs. The factors that hamper full co-operation
      between patients and researchers in the conduct of RCTs can be best addressed by:
      a) having more reliable estimates on the probabilities that new vs. established
      treatments will be successful, b) improving transparency in the clinical trial
      system to ensure fulfillment of "the social contract" between patients and
      researchers.
FAU - Djulbegovic, Benjamin
AU  - Djulbegovic B
AD  - Center for Evidence-based Medicine and Health Outcome Research, Clinical
      Translational Science Institute and Department of Internal Medicine, University
      of South Florida, Tampa, FL, USA. bdjulbeg@health.usf.edu
FAU - Hozo, Iztok
AU  - Hozo I
LA  - eng
PT  - Journal Article
DEP - 20120622
PL  - England
TA  - BMC Med Res Methodol
JT  - BMC medical research methodology
JID - 100968545
SB  - IM
MH  - Clinical Trials as Topic/ethics/*psychology
MH  - *Emotions
MH  - Ethical Theory
MH  - Female
MH  - *Game Theory
MH  - Guilt
MH  - Humans
MH  - Male
MH  - Monte Carlo Method
MH  - Moral Obligations
MH  - *Patient Participation
MH  - Rationalization
MH  - Researcher-Subject Relations/ethics/psychology
MH  - Risk Assessment/*methods
MH  - Sensitivity and Specificity
MH  - Social Values
MH  - Surveys and Questionnaires
MH  - Trust
PMC - PMC3473303
EDAT- 2012/06/26 06:00
MHDA- 2013/02/09 06:00
CRDT- 2012/06/26 06:00
PHST- 2011/05/13 00:00 [received]
PHST- 2012/05/14 00:00 [accepted]
PHST- 2012/06/26 06:00 [entrez]
PHST- 2012/06/26 06:00 [pubmed]
PHST- 2013/02/09 06:00 [medline]
AID - 1471-2288-12-85 [pii]
AID - 10.1186/1471-2288-12-85 [doi]
PST - epublish
SO  - BMC Med Res Methodol. 2012 Jun 22;12:85. doi: 10.1186/1471-2288-12-85.


PMID- 22726248
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121119
LR  - 20220410
IS  - 1755-7682 (Electronic)
IS  - 1755-7682 (Linking)
VI  - 5
IP  - 1
DP  - 2012 Jun 22
TI  - Understanding asthma and the metabolic syndrome - a Nigerian report.
PG  - 20
LID - 10.1186/1755-7682-5-20 [doi]
AB  - UNLABELLED: INTRODUCTION: Nigeria is a developing country that is currently
      witnessing an upsurge in diabetes mellitus and obesity with its antecedent
      consequences. There is also a fairly high prevalence of asthma affecting an
      estimated 10.7% of the population. There is no data presently on the possible
      presence of metabolic syndrome in Nigerian living with asthma. The study was
      conceived to determine the prevalence of metabolic syndrome among a population of
      asthmatics seen in our practice. We also attempt to compare asthma severity,
      control and pulmonary function tests in asthmatics with metabolic syndrome and
      those without. METHODOLOGY: This cross-sectional study was carried out at the
      asthma clinic of a tertiary teaching hospital. Ethical clearance was obtained
      from the research and ethics committee of the hospital. Written consent was
      obtained from the participants. Interviewer based questionnaire was used to
      obtain required information, anthropometric indices were recorded and clinical
      examinations done. Pulmonary function tests were carried out using desktop Alpha 
      Spirometer model 6000 made by Vitalograph UK (2007). Blood pressure was measured 
      using sphygmomanometer in mmHg. Fasting venous blood was taken for blood sugar
      and lipid profile. Metabolic syndrome was defined by the international diabetes
      Federation (IDF) criteria. RESULT: One hundred and fifty eight (158) asthmatics
      participated in the study comprising of 63 (39.9%) males and 95(60.1%) females.
      The age range was 14-78 years with a mean of 46.48+/-17.00 years. The mean
      duration of asthma diagnosis was 13.95+/-12.14 years. The prevalence of
      hypertension was 29.1%. 17 (10.8%) had fasting blood sugar above 100 mg/dl.
      Abdominal obesity was present in 78 (49.5%). The mean total cholesterol was
      192.63+/-40.7 mg/dl. HDL was low in 21(22%) of female and 3 (4.8%) male. The
      prevalence of metabolic syndrome was 17.7%, affecting 28 asthma patients. Asthma 
      control was affected by the presence of metabolic syndrome. P < 0.05. The
      pulmonary function test was not significantly affected by presence of metabolic
      syndrome. CONCLUSION: Metabolic syndrome prevalence is high in the population of 
      asthma patients studied. It is therefore important to screen patient with asthma 
      for this condition and treat to improve outcome.
FAU - Adeyeye, Olufunke O
AU  - Adeyeye OO
AD  - Department of Medicine, Lagos State University College of Medicine, 1/5 Oba
      Akinjobi G,R ,A, P,M,B, Ikeja, Lagos, 21266, Nigeria. olufunkeadeyeye@yahoo.com.
FAU - Ogbera, Anthonia O
AU  - Ogbera AO
FAU - Ogunleye, Olayinka O
AU  - Ogunleye OO
FAU - Brodie-Mens, Ayodeji T
AU  - Brodie-Mens AT
FAU - Abolarinwa, Folasade F
AU  - Abolarinwa FF
FAU - Bamisile, Raymond T
AU  - Bamisile RT
FAU - Onadeko, Babatunde O
AU  - Onadeko BO
LA  - eng
PT  - Journal Article
DEP - 20120622
PL  - England
TA  - Int Arch Med
JT  - International archives of medicine
JID - 101317943
PMC - PMC3499319
EDAT- 2012/06/26 06:00
MHDA- 2012/06/26 06:01
CRDT- 2012/06/26 06:00
PHST- 2012/02/10 00:00 [received]
PHST- 2012/06/11 00:00 [accepted]
PHST- 2012/06/26 06:00 [entrez]
PHST- 2012/06/26 06:00 [pubmed]
PHST- 2012/06/26 06:01 [medline]
AID - 1755-7682-5-20 [pii]
AID - 10.1186/1755-7682-5-20 [doi]
PST - epublish
SO  - Int Arch Med. 2012 Jun 22;5(1):20. doi: 10.1186/1755-7682-5-20.


PMID- 22724597
OWN - NLM
STAT- MEDLINE
DCOM- 20121127
LR  - 20191210
IS  - 1468-5922 (Electronic)
IS  - 0021-8774 (Linking)
VI  - 57
IP  - 3
DP  - 2012 Jun
TI  - The egg, the vessels and the words. From Izdubar to Answer to Job for an imaging 
      thinking.
PG  - 299-334
LID - 10.1111/j.1468-5922.2012.01973.x [doi]
AB  - This essay on The Red Book seeks to underscore a characteristic specific to
      Jung's approach to psychoanalysis. In this book, and more generally, in all of
      his writings, Jung's thinking is based on his personal experience of the
      unconscious, in which he leaves himself open to progressive encounters. Some of
      them, in the years 1913-14 and 1929-30, particularly his meeting with the giant
      Izdubar, were quite threatening. As a result, he forged an original way of
      thinking that is qualified here as 'imaging' and 'emergent'. The Red Book served 
      as the first vessel for theories Jung would later express. His way of thinking,
      with its failures and semi-successes, all of which are always temporary, of
      course, is compared to the art of the potter. The author shows the kinship
      between the formation of the main Jungian concepts and the teachings of the
      French poet, professor, and art critic Yves Bonnefoy. He also considers certain
      recurrent formal themes in the work of contemporary German painter and sculptor
      Anselm Kiefer. Lastly, this epistemological study, constantly aware of the
      demands of Jungian clinical practice, demonstrates the continuity in Jung's work,
      from The Red Book to Answer to Job, where Jung ultimately elaborated a conception
      of history that defines our ethical position today.
CI  - (c) 2012, The Society of Analytical Psychology.
FAU - Gaillard, Christian
AU  - Gaillard C
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - England
TA  - J Anal Psychol
JT  - The Journal of analytical psychology
JID - 0376573
SB  - IM
MH  - History, 20th Century
MH  - Humans
MH  - Jungian Theory/*history
MH  - Psychoanalysis/*history
MH  - Thinking
MH  - *Unconscious, Psychology
EDAT- 2012/06/26 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/06/26 06:00
PHST- 2012/06/26 06:00 [entrez]
PHST- 2012/06/26 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1111/j.1468-5922.2012.01973.x [doi]
PST - ppublish
SO  - J Anal Psychol. 2012 Jun;57(3):299-334. doi: 10.1111/j.1468-5922.2012.01973.x.


PMID- 22724571
OWN - NLM
STAT- MEDLINE
DCOM- 20120807
LR  - 20120625
IS  - 0862-495X (Print)
IS  - 0862-495X (Linking)
VI  - 25
IP  - 3
DP  - 2012
TI  - [Patient with B-CLL with a history of unrelated hematopoietic cells
      donation--retrospective analysis of CLL development and implication for the
      recipient].
PG  - 212-5
AB  - BACKGROUND: Donor cell leukemia (DCL) is a relatively rare but well documented
      complication of hematopoietic stem cell transplantation. So far, publications
      described only DCL arising de novo in the recipient. OBSERVATION: In this study, 
      we describe a case of chronic lymphocytic leukemia (B-CLL) developing in a
      volunteer unrelated donor from the Czech National Marrow Donors Registry (CNMDR) 
      several years after donation. From archival DNA sample, we have retrospectively
      found that subclinical CLL clone was already present at the time of donation but 
      early death of recipient prevented eventual development of DCL. This case
      documents well the long period between detection of B-CLL clone and full
      development of clinical-laboratory symptomatology. The medical and ethical
      questions posed by an isolated case of detection of hematological malignancy
      present either only in the donor or only in the recipient are discussed.
      CONCLUSION: The case demonstrates the increasing risk of development of various
      forms of DCL and thus highlights the need for long-term monitoring of stem cell
      donor, not only in terms of health of donor but also in terms of potential risks 
      for the recipient.
FAU - Jindra, P
AU  - Jindra P
AD  - Hematologicko-onkologicke oddeleni, FN Plzen. jindra@fnplzen.cz
FAU - Zejskova, L
AU  - Zejskova L
FAU - Pekova, S
AU  - Pekova S
FAU - Navratilova, J
AU  - Navratilova J
FAU - Schutzova, M
AU  - Schutzova M
FAU - Vokurka, S
AU  - Vokurka S
FAU - Koza, V
AU  - Koza V
LA  - cze
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - Pacient s B-CLL s anamnezou darovani krvetvornych bunek nepribuznemu pacientovi -
      retrospektivni sledovani vyvoje nemoci a dusledky pro prijemce.
PL  - Czech Republic
TA  - Klin Onkol
JT  - Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti
JID - 9425213
SB  - IM
MH  - *Hematopoietic Stem Cell Transplantation/adverse effects
MH  - Humans
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis/*etiology
MH  - Male
MH  - Middle Aged
MH  - *Unrelated Donors
EDAT- 2012/06/26 06:00
MHDA- 2012/08/08 06:00
CRDT- 2012/06/26 06:00
PHST- 2012/06/26 06:00 [entrez]
PHST- 2012/06/26 06:00 [pubmed]
PHST- 2012/08/08 06:00 [medline]
AID - 38173 [pii]
PST - ppublish
SO  - Klin Onkol. 2012;25(3):212-5.


PMID- 22723918
OWN - NLM
STAT- MEDLINE
DCOM- 20121212
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 6
DP  - 2012
TI  - Enhanced characterization of the smell of death by comprehensive two-dimensional 
      gas chromatography-time-of-flight mass spectrometry (GCxGC-TOFMS).
PG  - e39005
LID - 10.1371/journal.pone.0039005 [doi]
AB  - Soon after death, the decay process of mammalian soft tissues begins and leads to
      the release of cadaveric volatile compounds in the surrounding environment. The
      study of postmortem decomposition products is an emerging field of study in
      forensic science. However, a better knowledge of the smell of death and its
      volatile constituents may have many applications in forensic sciences. Domestic
      pigs are the most widely used human body analogues in forensic experiments,
      mainly due to ethical restrictions. Indeed, decomposition trials on human corpses
      are restricted in many countries worldwide. This article reports on the use of
      comprehensive two-dimensional gas chromatography coupled with time-of-flight mass
      spectrometry (GCxGC-TOFMS) for thanatochemistry applications. A total of 832 VOCs
      released by a decaying pig carcass in terrestrial ecosystem, i.e. a forest
      biotope, were identified by GCxGC-TOFMS. These postmortem compounds belong to
      many kinds of chemical class, mainly oxygen compounds (alcohols, acids, ketones, 
      aldehydes, esters), sulfur and nitrogen compounds, aromatic compounds such as
      phenolic molecules and hydrocarbons. The use of GCxGC-TOFMS in study of
      postmortem volatile compounds instead of conventional GC-MS was successful.
FAU - Dekeirsschieter, Jessica
AU  - Dekeirsschieter J
AD  - Department of Functional and Evolutionary Entomology, Gembloux Agro-Bio Tech,
      University of Liege, Gembloux, Belgium.
FAU - Stefanuto, Pierre-Hugues
AU  - Stefanuto PH
FAU - Brasseur, Catherine
AU  - Brasseur C
FAU - Haubruge, Eric
AU  - Haubruge E
FAU - Focant, Jean-Francois
AU  - Focant JF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120618
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Volatile Organic Compounds)
SB  - IM
MH  - Animals
MH  - Aromatherapy
MH  - Environment
MH  - *Forensic Medicine/methods
MH  - Gas Chromatography-Mass Spectrometry/*methods
MH  - Humans
MH  - Odorants/*analysis
MH  - Sus scrofa
MH  - Time Factors
MH  - Trees
MH  - Volatile Organic Compounds/*chemistry
PMC - PMC3377612
EDAT- 2012/06/23 06:00
MHDA- 2012/12/13 06:00
CRDT- 2012/06/23 06:00
PHST- 2012/03/05 00:00 [received]
PHST- 2012/05/16 00:00 [accepted]
PHST- 2012/06/23 06:00 [entrez]
PHST- 2012/06/23 06:00 [pubmed]
PHST- 2012/12/13 06:00 [medline]
AID - 10.1371/journal.pone.0039005 [doi]
AID - PONE-D-12-06649 [pii]
PST - ppublish
SO  - PLoS One. 2012;7(6):e39005. doi: 10.1371/journal.pone.0039005. Epub 2012 Jun 18.


PMID- 22723790
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 3
DP  - 2012
TI  - Evaluating Medical Student Communication/Professionalism Skills from a Patient's 
      Perspective.
PG  - 98
LID - 10.3389/fneur.2012.00098 [doi]
AB  - OBJECTIVE: Evaluate medical students' communication and professionalism skills
      from the perspective of the ambulatory patient and later compare these skills in 
      their first year of residency. METHODS: Students in third year neurology
      clerkship clinics see patients alone followed by a revisit with an attending
      neurologist. The patient is then asked to complete a voluntary, anonymous, Likert
      scale questionnaire rating the student on friendliness, listening to the patient,
      respecting the patient, using understandable language, and grooming. For students
      who had completed 1 year of residency these professionalism ratings were compared
      with those from their residency director. RESULTS: Seven hundred forty-two
      questionnaires for 165 clerkship students from 2007 to 2009 were analyzed.
      Eighty-three percent of forms were returned with an average of 5 per student. In 
      64% of questionnaires, patients rated students very good in all five categories; 
      in 35% patients selected either very good or good ratings; and <1% rated any
      student fair. No students were rated poor or very poor. Sixty-two percent of
      patients wrote complimentary comments about the students. From the Class of 2008,
      52% of students received "better than their peers" professionalism ratings from
      their PGY1 residency directors and only one student was rated "below their
      peers." CONCLUSION: This questionnaire allowed patient perceptions of their
      students' communication/professionalism skills to be evaluated in a systematic
      manner. Residency director ratings of professionalism of the same students at the
      end of their first year of residency confirms continued professional behavior.
FAU - Davis, Larry E
AU  - Davis LE
AD  - Neurology Service, New Mexico Veterans Affairs Health Care System Albuquerque,
      NM, USA.
FAU - King, Molly K
AU  - King MK
FAU - Wayne, Sharon J
AU  - Wayne SJ
FAU - Kalishman, Summers G
AU  - Kalishman SG
LA  - eng
PT  - Journal Article
DEP - 20120620
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC3379033
OTO - NOTNLM
OT  - medical education
OT  - medical ethics
OT  - professional conduct
EDAT- 2012/06/23 06:00
MHDA- 2012/06/23 06:01
CRDT- 2012/06/23 06:00
PHST- 2012/05/12 00:00 [received]
PHST- 2012/05/30 00:00 [accepted]
PHST- 2012/06/23 06:00 [entrez]
PHST- 2012/06/23 06:00 [pubmed]
PHST- 2012/06/23 06:01 [medline]
AID - 10.3389/fneur.2012.00098 [doi]
PST - epublish
SO  - Front Neurol. 2012 Jun 20;3:98. doi: 10.3389/fneur.2012.00098. eCollection 2012.


PMID- 22723563
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20220330
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 264
IP  - 1
DP  - 2012 Jul
TI  - Assessment of disease activity in multiple sclerosis phenotypes with combined
      gadolinium- and superparamagnetic iron oxide-enhanced MR imaging.
PG  - 225-33
LID - 10.1148/radiol.12111416 [doi]
AB  - PURPOSE: To compare magnetic resonance (MR) imaging features of multiple
      sclerosis (MS) lesions after the administration of a gadolinium-based contrast
      agent and ultrasmall superparamagnetic iron oxide (USPIO) particles among the
      clinical phenotypes of MS and over time. MATERIALS AND METHODS: This study was
      approved by the local ethics committee, and written informed consent was obtained
      from all patients. Twenty-four patients with MS (10 with relapsing and 14 with
      progressive forms) underwent clinical and gadolinium- and USPIO-enhanced MR
      examinations at baseline and 6-month follow-up. The number of lesions that
      enhanced with gadolinium alone, USPIO alone, or both was compared with the
      Pearson chi2 or Fisher exact test, and lesion sizes were compared with the
      Wilcoxon Mann-Whitney U test. At 6-month follow-up, the lesion signal intensity
      on precontrast T1-weighted images and the enhancement after repeat injection of
      the contrast agent were compared with the baseline postcontrast imaging features 
      by using the McNemar test. RESULTS: Fifty-six lesions were considered active
      owing to contrast enhancement at baseline; 37 lesions (66%) in 10 patients
      enhanced with gadolinium. The use of USPIO helped detect 19 additional lesions
      (34%), and two additional patients were classified as having active disease.
      Thus, the use of both agents enabled detection of 51% (19 of 37 lesions) more
      lesions than with gadolinium alone. Enhanced lesions were more frequently
      observed in the relapsing compared with the progressive forms of MS (P<.0001).
      USPIO enhancement, in the form of ringlike patterns, could also be observed on
      T1-weighted images in patients with progressive MS, enabling the detection of
      five lesions in addition to the five detected with gadolinium in this phenotype. 
      Lesions that enhanced with both contrast agents at baseline were larger (mean
      size, 6.5 mm+/-3.8; P=.001) and were more likely to persistently enhance at
      6-month follow-up (seven of 27 lesions, P<.0001) compared with those that
      enhanced only with gadolinium (mean size, 4.9 mm+/-2.2; one of nine lesions) or
      USPIO (mean size, 3.5 mm+/-1.5; 0 of 17 lesions). CONCLUSION: The combination of 
      gadolinium and USPIO in patients with MS can help identify additional active
      lesions compared with the current standard, the gadolinium-only approach, even in
      progressive forms of MS. Lesions that enhance with both agents may exhibit a more
      aggressive evolution than those that enhance with only one contrast agent.
CI  - (c) RSNA, 2012.
FAU - Tourdias, Thomas
AU  - Tourdias T
AD  - Department of Neuroradiology and INSERM U1049, CHU de Bordeaux, Universite
      Bordeaux Segalen, Bordeaux, France. thomas.tourdias@chu-bordeaux.fr
FAU - Roggerone, Stephanie
AU  - Roggerone S
FAU - Filippi, Massimo
AU  - Filippi M
FAU - Kanagaki, Mitsunori
AU  - Kanagaki M
FAU - Rovaris, Marco
AU  - Rovaris M
FAU - Miller, David H
AU  - Miller DH
FAU - Petry, Klaus G
AU  - Petry KG
FAU - Brochet, Bruno
AU  - Brochet B
FAU - Pruvo, Jean-Pierre
AU  - Pruvo JP
FAU - Radue, Ernst-Wilhelm
AU  - Radue EW
FAU - Dousset, Vincent
AU  - Dousset V
LA  - eng
PT  - Clinical Trial, Phase II
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - 0 (Dextrans)
RN  - 0 (Magnetite Nanoparticles)
RN  - 0 (Organometallic Compounds)
RN  - 0 (ferumoxtran-10)
RN  - 6HG8UB2MUY (Meglumine)
RN  - L0ND3981AG (gadoterate meglumine)
SB  - IM
MH  - Adult
MH  - Chi-Square Distribution
MH  - Contrast Media
MH  - Dextrans
MH  - Disability Evaluation
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Magnetic Resonance Imaging/*methods
MH  - Magnetite Nanoparticles
MH  - Male
MH  - Meglumine
MH  - Middle Aged
MH  - Multiple Sclerosis/*pathology
MH  - Organometallic Compounds
MH  - Phenotype
MH  - Prospective Studies
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Statistics, Nonparametric
EDAT- 2012/06/23 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/06/23 06:00
PHST- 2012/06/23 06:00 [entrez]
PHST- 2012/06/23 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
AID - 264/1/225 [pii]
AID - 10.1148/radiol.12111416 [doi]
PST - ppublish
SO  - Radiology. 2012 Jul;264(1):225-33. doi: 10.1148/radiol.12111416.


PMID- 22722690
OWN - NLM
STAT- MEDLINE
DCOM- 20121031
LR  - 20120622
IS  - 1662-8063 (Electronic)
IS  - 1662-4246 (Linking)
VI  - 15
IP  - 5
DP  - 2012
TI  - The necessity of broad consent and complementary regulations for the protection
      of personal data in biobanks: what can we learn from the German case?
PG  - 263-71
LID - 10.1159/000336604 [doi]
AB  - In order to follow population-based approaches for certain causes and risks of
      illnesses, more and more biobanks have been set up during the last years. Here,
      samples and personal data of the donors are collected and saved, whereby concrete
      research aims, at the time of storage of the bio-probes and the related data, are
      mostly undetermined. Biobanks, therefore, have the character of a collection of
      material and data that can be used for initially undetermined research projects. 
      Under legal aspects the question arises whether the data subjects can consent
      only to an already determined use of their samples and data or can consent to a
      general use for research. In this article, we discuss the validity of broad
      consent and in how far the arising deficits in data protection need to be and can
      be compensated. Broad consent is, in our opinion, generally legally valid. It
      leads, however, to an encroachment of the ruling basic principles of data
      protection law. The 5-pillar concept of the German Ethics Council therefore
      suggests additional regulations to compensate the lacks of broad consent. While
      other recommendations and opinions - as far as can be seen - do only describe in 
      vague terms the conditions for statutory regulations, the opinion of the German
      Ethics Council comprises very concrete statements. It, therefore, might serve as 
      a model in the international debate on privacy and biobanks. As a result of the
      current debate, we identify this as a paradigm shift in data protection in
      biobanks.
CI  - Copyright (c) 2012 S. Karger AG, Basel.
FAU - Taupitz, J
AU  - Taupitz J
AD  - University of Mannheim, Faculty of Law, Mannheim, Germany.
      taupitz@jura.uni-mannheim.de
FAU - Weigel, J
AU  - Weigel J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120620
PL  - Switzerland
TA  - Public Health Genomics
JT  - Public health genomics
JID - 101474167
SB  - IM
MH  - Biological Specimen Banks/ethics/*legislation & jurisprudence
MH  - Biomedical Research/ethics/*legislation & jurisprudence
MH  - Computer Security/*legislation & jurisprudence
MH  - Germany
MH  - Humans
MH  - Informed Consent/ethics/*legislation & jurisprudence
MH  - Privacy/*legislation & jurisprudence
EDAT- 2012/06/23 06:00
MHDA- 2012/11/01 06:00
CRDT- 2012/06/23 06:00
PHST- 2012/06/23 06:00 [entrez]
PHST- 2012/06/23 06:00 [pubmed]
PHST- 2012/11/01 06:00 [medline]
AID - 000336604 [pii]
AID - 10.1159/000336604 [doi]
PST - ppublish
SO  - Public Health Genomics. 2012;15(5):263-71. doi: 10.1159/000336604. Epub 2012 Jun 
      20.


PMID- 22722689
OWN - NLM
STAT- MEDLINE
DCOM- 20121031
LR  - 20120622
IS  - 1662-8063 (Electronic)
IS  - 1662-4246 (Linking)
VI  - 15
IP  - 5
DP  - 2012
TI  - IT solutions for privacy protection in biobanking.
PG  - 254-62
LID - 10.1159/000336663 [doi]
AB  - Biobanks containing human biological samples and associated data are key
      resources for the advancement of medical research. Efficient access to samples
      and data increases competitiveness in medical research, reduces effort and time
      for achieving scientific results and promotes scientific progress. In order to
      address upcoming health challenges, there is increasing need for transnational
      collaboration. This requires innovative solutions improving interoperability of
      biobanks in fields such as sample and data management as well as governance
      including ethical and legal frameworks. In this context, rights and expectations 
      of donors to determine the usage of their biological material and data and to
      ensure their privacy have to be observed. We discuss the benefits of biobanks,
      the needs to support medical research and the societal demands and regulations,
      in particular, securing the rights of donors and present IT solutions that allow 
      both to maintain the security of personal data and to increase the efficiency of 
      access to data in biobanks. Disclosure filters are discussed as a strategy to
      combine European public expectations concerning informed consent with the
      requirements of biobank research.
CI  - Copyright (c) 2012 S. Karger AG, Basel.
FAU - Eder, J
AU  - Eder J
AD  - Department of Informatics Systems, University of Klagenfurt, Klagenfurt, Austria.
      johann.eder@aau.at
FAU - Gottweis, H
AU  - Gottweis H
FAU - Zatloukal, K
AU  - Zatloukal K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120620
PL  - Switzerland
TA  - Public Health Genomics
JT  - Public health genomics
JID - 101474167
SB  - IM
MH  - Biological Specimen Banks/ethics/*legislation & jurisprudence
MH  - Biomedical Research/ethics/*legislation & jurisprudence
MH  - Computer Security/*legislation & jurisprudence
MH  - Humans
MH  - Information Dissemination/*legislation & jurisprudence
MH  - Information Storage and Retrieval/*methods
MH  - Privacy/*legislation & jurisprudence
EDAT- 2012/06/23 06:00
MHDA- 2012/11/01 06:00
CRDT- 2012/06/23 06:00
PHST- 2012/06/23 06:00 [entrez]
PHST- 2012/06/23 06:00 [pubmed]
PHST- 2012/11/01 06:00 [medline]
AID - 000336663 [pii]
AID - 10.1159/000336663 [doi]
PST - ppublish
SO  - Public Health Genomics. 2012;15(5):254-62. doi: 10.1159/000336663. Epub 2012 Jun 
      20.


PMID- 22722688
OWN - NLM
STAT- MEDLINE
DCOM- 20121031
LR  - 20120622
IS  - 1662-8063 (Electronic)
IS  - 1662-4246 (Linking)
VI  - 15
IP  - 5
DP  - 2012
TI  - Securing the data economy: translating privacy and enacting security in the
      development of DataSHIELD.
PG  - 243-53
LID - 10.1159/000336673 [doi]
AB  - Contemporary bioscience is seeing the emergence of a new data economy: with data 
      as its fundamental unit of exchange. While sharing data within this new 'economy'
      provides many potential advantages, the sharing of individual data raises
      important social and ethical concerns. We examine ongoing development of one
      technology, DataSHIELD, which appears to elide privacy concerns about sharing
      data by enabling shared analysis while not actually sharing any individual-level 
      data. We combine presentation of the development of DataSHIELD with presentation 
      of an ethnographic study of a workshop to test the technology. DataSHIELD
      produced an application of the norm of privacy that was practical, flexible and
      operationalizable in researchers' everyday activities, and one which fulfilled
      the requirements of ethics committees. We demonstrated that an analysis run via
      DataSHIELD could precisely replicate results produced by a standard analysis
      where all data are physically pooled and analyzed together. In developing
      DataSHIELD, the ethical concept of privacy was transformed into an issue of
      security. Development of DataSHIELD was based on social practices as well as
      scientific and ethical motivations. Therefore, the 'success' of DataSHIELD would,
      likewise, be dependent on more than just the mathematics and the security of the 
      technology.
CI  - Copyright (c) 2012 S. Karger AG, Basel.
FAU - Murtagh, M J
AU  - Murtagh MJ
AD  - Data to Knowledge for Practice, University of Leicester, Leicester, UK.
      mm399@le.ac.uk
FAU - Demir, I
AU  - Demir I
FAU - Jenkings, K N
AU  - Jenkings KN
FAU - Wallace, S E
AU  - Wallace SE
FAU - Murtagh, B
AU  - Murtagh B
FAU - Boniol, M
AU  - Boniol M
FAU - Bota, M
AU  - Bota M
FAU - Laflamme, P
AU  - Laflamme P
FAU - Boffetta, P
AU  - Boffetta P
FAU - Ferretti, V
AU  - Ferretti V
FAU - Burton, P R
AU  - Burton PR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120620
PL  - Switzerland
TA  - Public Health Genomics
JT  - Public health genomics
JID - 101474167
SB  - IM
MH  - *Biomedical Research
MH  - Computer Security/ethics/*legislation & jurisprudence/*standards
MH  - Confidentiality/ethics/legislation & jurisprudence/*standards
MH  - Ethics Committees
MH  - Humans
MH  - Information Storage and Retrieval/*methods
MH  - Research
MH  - *Research Design
EDAT- 2012/06/23 06:00
MHDA- 2012/11/01 06:00
CRDT- 2012/06/23 06:00
PHST- 2012/06/23 06:00 [entrez]
PHST- 2012/06/23 06:00 [pubmed]
PHST- 2012/11/01 06:00 [medline]
AID - 000336673 [pii]
AID - 10.1159/000336673 [doi]
PST - ppublish
SO  - Public Health Genomics. 2012;15(5):243-53. doi: 10.1159/000336673. Epub 2012 Jun 
      20.


PMID- 22722687
OWN - NLM
STAT- MEDLINE
DCOM- 20121031
LR  - 20120622
IS  - 1662-8063 (Electronic)
IS  - 1662-4246 (Linking)
VI  - 15
IP  - 5
DP  - 2012
TI  - Consent and research governance in biobanks: evidence from focus groups with
      medical researchers.
PG  - 232-42
LID - 10.1159/000336544 [doi]
AB  - Much is known about patient attitudes to ethical and legal questions in the
      context of biobanking, particularly regarding privacy protection and consent.
      However, little is known about the attitudes of medical researchers who use
      biobanks for research to these issues. Four focus groups with medical researchers
      in the UK were conducted in 2010-2011. The study highlights a range of issues
      associated with the research oversight and consent process (including obtaining
      ethical approval to use biobank samples and particular concerns for international
      studies), the benefits and limitations of broad consent and the possibilities of 
      revoking consent. Many of these issues originate in the relatively static consent
      processes that currently govern the biobanking process. However, it is now
      possible to develop reliable, dynamic processes using information technology that
      can resolve many of these ethical and legal concerns. The 'dynamic consent'
      approach therefore offers the opportunity to fundamentally transform the process 
      of medical research in a manner that addresses the concerns of both patients and 
      medical researchers.
CI  - Copyright (c) 2012 S. Karger AG, Basel.
FAU - Whitley, E A
AU  - Whitley EA
AD  - Information Systems and Innovation Group, London School of Economics and
      Political Science, London, UK. e.a.whitley@lse.ac.uk
FAU - Kanellopoulou, N
AU  - Kanellopoulou N
FAU - Kaye, J
AU  - Kaye J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120620
PL  - Switzerland
TA  - Public Health Genomics
JT  - Public health genomics
JID - 101474167
SB  - IM
MH  - Biological Specimen Banks/*ethics/legislation & jurisprudence/trends
MH  - Biomedical Research/*ethics/legislation & jurisprudence
MH  - Focus Groups
MH  - Humans
MH  - Informed Consent/*ethics/legislation & jurisprudence
MH  - Morals
MH  - Research Personnel/*ethics/legislation & jurisprudence
EDAT- 2012/06/23 06:00
MHDA- 2012/11/01 06:00
CRDT- 2012/06/23 06:00
PHST- 2012/06/23 06:00 [entrez]
PHST- 2012/06/23 06:00 [pubmed]
PHST- 2012/11/01 06:00 [medline]
AID - 000336544 [pii]
AID - 10.1159/000336544 [doi]
PST - ppublish
SO  - Public Health Genomics. 2012;15(5):232-42. doi: 10.1159/000336544. Epub 2012 Jun 
      20.


PMID- 22721424
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20211021
IS  - 1471-2474 (Electronic)
IS  - 1471-2474 (Linking)
VI  - 13
DP  - 2012 Jun 21
TI  - Design of the muscles in motion study: a randomized controlled trial to evaluate 
      the efficacy and feasibility of an individually tailored home-based exercise
      training program for children and adolescents with juvenile dermatomyositis.
PG  - 108
LID - 10.1186/1471-2474-13-108 [doi]
AB  - BACKGROUND: Juvenile dermatomyositis (JDM) is a rare, often chronic, systemic
      autoimmune disease of childhood, characterized by inflammation of the
      microvasculature of the skeletal muscle and skin. Prominent clinical features
      include significant exercise intolerance, muscle weakness, and fatigue. Despite
      pharmacological improvements, these clinical features continue to affect patients
      with JDM, even when the disease is in remission. Exercise training is
      increasingly utilized as a non-pharmacological intervention in the clinical
      management of (adult) patients with chronic inflammatory conditions; however no
      randomized controlled trials (RCT) have been performed in JDM. In the current
      study, the efficacy and feasibility of an exercise training program in patients
      with JDM will be examined. METHODS/DESIGN: Subjects (n = 30) will include 8-18
      year olds diagnosed with JDM. The intervention consists of an individually
      tailored 12-weeks home-based exercise training program in which interval training
      on a treadmill is alternated with strength training during each session. The
      program is based on previous literature and designed with a defined frequency,
      intensity, time, and type of exercise (FITT principles). Primary outcome measures
      include aerobic exercise capacity, isometric muscle strength, and perception of
      fatigue. The study methodology has been conceived according to the standards of
      the CONSORT guidelines. The current study will be a multi-center (4 Dutch
      University Medical Centers) RCT, with the control group also entering the
      training arm directly after completion of the initial protocol. Randomization is 
      stratified according to age and gender. DISCUSSION: The current study will
      provide evidence on the efficacy and feasibility of an individually tailored
      12-week home-based exercise training program in youth with JDM. TRIAL
      REGISTRATION: Medical Ethics Committee of the University Medical Center Utrecht, 
      the Netherlands: 11-336; Netherlands Trial Register (NTR): NTR 3184.
FAU - Habers, Esther A
AU  - Habers EA
AD  - Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the
      Netherlands.
FAU - van Brussel, Marco
AU  - van Brussel M
FAU - Langbroek-Amersfoort, Anneli C
AU  - Langbroek-Amersfoort AC
FAU - van Royen-Kerkhof, Annet
AU  - van Royen-Kerkhof A
FAU - Takken, Tim
AU  - Takken T
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20120621
PL  - England
TA  - BMC Musculoskelet Disord
JT  - BMC musculoskeletal disorders
JID - 100968565
RN  - Amyopathic dermatomyositis
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Child
MH  - Dermatomyositis/diagnosis/physiopathology/*therapy
MH  - *Exercise Therapy/adverse effects/methods
MH  - Exercise Tolerance
MH  - Feasibility Studies
MH  - Female
MH  - *Home Care Services
MH  - Humans
MH  - Male
MH  - Muscle Contraction
MH  - Muscle Fatigue
MH  - Muscle Strength
MH  - Muscle, Skeletal/*physiopathology
MH  - Netherlands
MH  - *Research Design
MH  - Resistance Training
MH  - Time Factors
MH  - Treatment Outcome
PMC - PMC3478183
EDAT- 2012/06/23 06:00
MHDA- 2013/03/13 06:00
CRDT- 2012/06/23 06:00
PHST- 2012/04/25 00:00 [received]
PHST- 2012/06/08 00:00 [accepted]
PHST- 2012/06/23 06:00 [entrez]
PHST- 2012/06/23 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
AID - 1471-2474-13-108 [pii]
AID - 10.1186/1471-2474-13-108 [doi]
PST - epublish
SO  - BMC Musculoskelet Disord. 2012 Jun 21;13:108. doi: 10.1186/1471-2474-13-108.


PMID- 22721260
OWN - NLM
STAT- MEDLINE
DCOM- 20130115
LR  - 20141114
IS  - 1362-301X (Electronic)
IS  - 0269-9052 (Linking)
VI  - 26
IP  - 11
DP  - 2012
TI  - The ethics of using placebo medication in a non-capacitous patient.
PG  - 1397-400
LID - 10.3109/02699052.2012.694560 [doi]
AB  - BACKGROUND: The use of placebo has long been controversial. Whilst evidence
      accumulates regarding it's beneficial and safe effects, ethical issues around the
      eroding of patient autonomy and accusations of deception stop most doctors
      prescribing inert placebo substances. CASE STUDY: This paper presents a case of a
      non-capacitous patient who was prescribed placebo medication, as a 'best
      interest' decision under the Mental Capacity Act 2005. Good and safe effect was
      achieved in treating the patient's anxiety. This paper argues that in the
      non-capacitous patient, the principles of beneficence and justice may outweigh
      those of autonomy and, therefore, prescription of placebo medication should be
      more widely considered for this significant group of patients.
FAU - Bolton, Philippa
AU  - Bolton P
AD  - WalkergatePark Hospital, Newcastle, NE6 4QD, UK. philippa.bolton@ntw.nhs.uk
FAU - Shotton, Laura
AU  - Shotton L
FAU - Young, Anthony
AU  - Young A
FAU - Grace, Janet
AU  - Grace J
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20120621
PL  - England
TA  - Brain Inj
JT  - Brain injury
JID - 8710358
RN  - 0 (Placebos)
SB  - IM
MH  - Adult
MH  - *Beneficence
MH  - Ethics, Medical
MH  - Female
MH  - Humans
MH  - Informed Consent
MH  - Patient Advocacy
MH  - Personal Autonomy
MH  - Physician-Patient Relations/*ethics
MH  - *Placebos/administration & dosage
EDAT- 2012/06/23 06:00
MHDA- 2013/01/16 06:00
CRDT- 2012/06/23 06:00
PHST- 2012/06/23 06:00 [entrez]
PHST- 2012/06/23 06:00 [pubmed]
PHST- 2013/01/16 06:00 [medline]
AID - 10.3109/02699052.2012.694560 [doi]
PST - ppublish
SO  - Brain Inj. 2012;26(11):1397-400. doi: 10.3109/02699052.2012.694560. Epub 2012 Jun
      21.


PMID- 22720929
OWN - NLM
STAT- MEDLINE
DCOM- 20121105
LR  - 20220408
IS  - 1525-3198 (Electronic)
IS  - 0022-0302 (Linking)
VI  - 95
IP  - 7
DP  - 2012 Jul
TI  - Effectiveness of different regimens of a collective topical treatment using a
      solution of copper and zinc chelates in the cure of digital dermatitis in dairy
      farms under field conditions.
PG  - 3722-35
LID - 10.3168/jds.2011-4983 [doi]
AB  - A controlled field trial was conducted to evaluate in dairy cattle the benefit
      provided by different regimens of a collective topical treatment using a solution
      of copper and zinc chelates to cure digital dermatitis (DD) compared with
      individual treatment alone, and further to investigate factors that could explain
      variations in the clinical cure of DD lesions over 6 mo. The study was conducted 
      between November 2009 and October 2010 and involved 4,677 dairy cows from 52
      French dairy farms on which DD was endemic. The farms were quasi-randomly
      allocated to 1 of 4 treatment regimens for 6 mo: no collective treatment
      (control), walk-through footbath during 4 consecutive milkings every 4 wk (FB/4W)
      or every 2 wk (FB/2W) and collective spraying during 2 milkings every 2 wk
      (CS/2W). For ethical and welfare reasons, all farmers also had to treat all
      detected active DD lesions with individual topical spraying of oxytetracycline.
      Digital dermatitis and leg hygiene were scored on all lactating cows during
      milking 7 times every 4 wk by 14 trained investigators. During these farm visits,
      data related to farm management were also collected. The curative effectiveness
      of collective treatments was assessed through a Cox survival frailty model as the
      probability of cure of an active DD lesion during at least 2 consecutive visits. 
      The model was adjusted for farm and cow risk factors as well as initial DD
      prevalence. Monthly DD cure rates were 58, 55, 76, and 76% in the control, FB/4W,
      FB/2W, and CS/2W regimens, respectively. The spontaneous monthly cure rate for
      untreated active DD lesions was 61%. Hazard of cure of DD was increased by 1.28
      and 1.41 when walk-through footbath and collective spraying, respectively, were
      applied over 2 d every 2 wk compared with the control regimen. Applying a
      walk-through footbath 2 d every 4 wk was not sufficient to improve the cure of DD
      compared with individual treatments alone. Three main factors were identified as 
      speeding DD healing: cleanliness of the feet, initial small size of the DD
      lesion, and additional individual topical treatment. Grazing tended to speed DD
      healing. These results highlight the need of combining several control measures, 
      including individual and collective topical treatments, and improving foot
      hygiene and the early detection of DD lesions to ensure a high cure rate and
      rapid curing of digital dermatitis on endemically affected farms.
CI  - Copyright (c) 2012 American Dairy Science Association. Published by Elsevier Inc.
      All rights reserved.
FAU - Relun, A
AU  - Relun A
AD  - UMT Cattle Herd Health Control, F-44307 Nantes, France.
      anne.relun@oniris-nantes.fr
FAU - Lehebel, A
AU  - Lehebel A
FAU - Bareille, N
AU  - Bareille N
FAU - Guatteo, R
AU  - Guatteo R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Dairy Sci
JT  - Journal of dairy science
JID - 2985126R
RN  - 0 (Chelating Agents)
RN  - 789U1901C5 (Copper)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Administration, Topical
MH  - Animals
MH  - Cattle
MH  - Cattle Diseases/*drug therapy
MH  - Chelating Agents/administration & dosage/*therapeutic use
MH  - Copper/administration & dosage/*therapeutic use
MH  - Dairying/methods
MH  - Digital Dermatitis/*drug therapy
MH  - Female
MH  - Hoof and Claw/drug effects
MH  - Treatment Outcome
MH  - Zinc/administration & dosage/*therapeutic use
EDAT- 2012/06/23 06:00
MHDA- 2012/11/06 06:00
CRDT- 2012/06/23 06:00
PHST- 2011/09/27 00:00 [received]
PHST- 2012/02/10 00:00 [accepted]
PHST- 2012/06/23 06:00 [entrez]
PHST- 2012/06/23 06:00 [pubmed]
PHST- 2012/11/06 06:00 [medline]
AID - S0022-0302(12)00352-9 [pii]
AID - 10.3168/jds.2011-4983 [doi]
PST - ppublish
SO  - J Dairy Sci. 2012 Jul;95(7):3722-35. doi: 10.3168/jds.2011-4983.


PMID- 22720727
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140520
LR  - 20211021
IS  - 1756-994X (Electronic)
IS  - 1756-994X (Linking)
VI  - 4
IP  - 6
DP  - 2012
TI  - Integrating stakeholder perspectives into the translation of cell-free fetal DNA 
      testing for aneuploidy.
PG  - 49
LID - 10.1186/gm348 [doi]
AB  - BACKGROUND: The translation of novel genomic technologies from bench to bedside
      enjoins the comprehensive consideration of the perspectives of all stakeholders
      who stand to influence, or be influenced by, the translational course.
      Non-invasive prenatal aneuploidy testing that utilizes cell-free fetal DNA
      (cffDNA) circulating in maternal blood is one example of an innovative technology
      that promises significant benefits for its intended end users; however, it is
      currently uncertain whether it will achieve widespread clinical implementation.
      We conducted qualitative interviews with 18 diverse stakeholders in this domain, 
      including prospective users of the technology and healthcare personnel,
      researchers and developers, and experts in social, legal, and regulatory aspects 
      of genetic technology, and a pilot survey of 62 obstetric healthcare providers.
      Analysis of interview and survey data was combined with a review of the
      proceedings of a full-day, multidisciplinary conference on the topic and
      published scientific and ethics literature surrounding this and other relevant
      technologies. DISCUSSION: We constructed potential pathways for technological
      implementation, identified broad stakeholder classes party to these translational
      processes, and performed a preliminary assessment of the viewpoints and
      interrelations among these diverse stakeholders. Some of the stakeholders whose
      priorities are critical to understand and integrate into translation include
      pregnant women and their families; healthcare providers; scientists, their
      institutions or companies, and the funding agencies that support them; regulatory
      and judicial bodies; third-party payers; professional societies; educational
      systems; disability rights communities; and other representatives from civil
      society. Stakeholder interviews, survey findings, and conference proceedings add 
      complexity to these envisioned pathways and also demonstrate a paramount need to 
      incorporate an iterative stakeholder analysis early and throughout the
      translational endeavor. We believe that the translational framework that we have 
      developed will help guide crucial future stakeholder mapping and engagement
      activities for cffDNA aneuploidy testing and inform novel methods of technology
      assessment for other developments in the growing field of genomic medicine.
      SUMMARY: Mapping potential pathways for implementation and exploring the
      attitudes and interrelations of diverse stakeholders may lead to more effective
      translation of a novel method of prenatal aneuploidy testing.
FAU - Sayres, Lauren C
AU  - Sayres LC
AD  - Stanford Center for Biomedical Ethics, Stanford University, 1215 Welch Road
      Modular A, Stanford, California, 94301, USA.
FAU - Allyse, Megan
AU  - Allyse M
AD  - Stanford Center for Biomedical Ethics, Stanford University, 1215 Welch Road
      Modular A, Stanford, California, 94301, USA.
FAU - Cho, Mildred K
AU  - Cho MK
AD  - Stanford Center for Biomedical Ethics, Stanford University, 1215 Welch Road
      Modular A, Stanford, California, 94301, USA ; Department of Pediatrics, Division 
      of Genetics, Stanford University, 1215 Welch Road Modular A, Stanford,
      California, 94301, USA.
LA  - eng
PT  - Journal Article
DEP - 20120621
PL  - England
TA  - Genome Med
JT  - Genome medicine
JID - 101475844
PMC - PMC3738226
EDAT- 2012/06/23 06:00
MHDA- 2012/06/23 06:01
CRDT- 2012/06/23 06:00
PHST- 2012/01/06 00:00 [received]
PHST- 2012/05/23 00:00 [revised]
PHST- 2012/06/21 00:00 [accepted]
PHST- 2012/06/23 06:00 [entrez]
PHST- 2012/06/23 06:00 [pubmed]
PHST- 2012/06/23 06:01 [medline]
AID - 10.1186/gm348 [doi]
AID - gm348 [pii]
PST - epublish
SO  - Genome Med. 2012 Jun 21;4(6):49. doi: 10.1186/gm348. eCollection 2012.


PMID- 22720695
OWN - NLM
STAT- MEDLINE
DCOM- 20121031
LR  - 20211021
IS  - 1479-5876 (Electronic)
IS  - 1479-5876 (Linking)
VI  - 10
DP  - 2012 Jun 21
TI  - Clinical trial considerations on male contraception and collection of pregnancy
      information from female partners.
PG  - 129
LID - 10.1186/1479-5876-10-129 [doi]
AB  - BACKGROUND: There is little guidance regarding the risk of exposure of pregnant
      women/ women of childbearing potential to genotoxic or teratogenic compounds via 
      vaginal dose delivered through seminal fluid during sexual intercourse. METHOD:
      We summarize current thinking and provide clinical trial considerations for a
      consistent approach to contraception for males exposed to genotoxic and/or
      teratogenic compounds or to compounds of unknown teratogenicity, and for
      collection of pregnancy data from their female partners. RESULTS: Where toxicity 
      testing demonstrates genotoxic potential, condom use is required during exposure 
      and for 5 terminal plasma half-lives plus 74 days (one human spermatogenesis
      cycle) to avoid conception.For non-genotoxic small molecules and immunoglobulins 
      with unknown teratogenic potential or without a no observed adverse effect level 
      (NOAEL) from embryo-fetal development (EFD) studies and no minimal anticipated
      biological effect level (MABEL), condom use is recommended for males with
      pregnant partner/female partner of childbearing potential. For teratogenic small 
      molecules with estimated seminal fluid concentration and a margin between
      projected maternal area under the curve (AUC) and NOAEL AUC from EFD studies of
      >/=300 (>/=100 for immunoglobulins) or in the absence of a NOAEL with a margin
      between MABEL plasma concentration and maternal Cmax of >/=300 (>/=10 for
      immunoglobulins), condom use is not required. However, condom use is required for
      margins below the thresholds previously indicated. For small molecules with
      available seminal fluid concentrations, condom use is required if margins are
      <100 instead of <300. Condom use should continue for as long as the projected
      margin is at or above the defined thresholds. Pregnancy data should be
      proactively collected if pregnancy occurs during the condom use period required
      for males exposed to first-in-class molecules or to molecules with a target/class
      shown to be teratogenic, embryotoxic or fetotoxic in human or preclinical
      experiments. CONCLUSION: These recommendations, based on a precaution principle, 
      provide a consistent approach for minimizing the risk of embryo-fetal exposure to
      potentially harmful drugs during pregnancy of female partners of males in
      clinical trials. Proactive targeted collection of pregnancy information from
      female partners should help determine the teratogenic potential of a drug and
      minimize background noise and ethical/logistical issues.
FAU - Banholzer, Maria Longauer
AU  - Banholzer ML
AD  - Safety Risk Management, Licensing & Early Development, F. Hoffmann-La Roche AG
      Ltd, Basel, CH, Switzerland. maria.longauer_banholzer@roche.com
FAU - Buergin, Heinrich
AU  - Buergin H
FAU - Wandel, Christoph
AU  - Wandel C
FAU - Schmitt, Georg
AU  - Schmitt G
FAU - Gocke, Elmar
AU  - Gocke E
FAU - Peck, Richard
AU  - Peck R
FAU - Singer, Thomas
AU  - Singer T
FAU - Reynolds, Theresa
AU  - Reynolds T
FAU - Mannino, Marie
AU  - Mannino M
FAU - Deutsch, Jonathan
AU  - Deutsch J
FAU - Doessegger, Lucette
AU  - Doessegger L
LA  - eng
PT  - Journal Article
DEP - 20120621
PL  - England
TA  - J Transl Med
JT  - Journal of translational medicine
JID - 101190741
SB  - IM
MH  - *Clinical Trials as Topic
MH  - Condoms
MH  - Contraception/*statistics & numerical data
MH  - Data Collection/*statistics & numerical data
MH  - Decision Trees
MH  - Female
MH  - Humans
MH  - Male
MH  - Pregnancy
MH  - *Sexual Partners
PMC - PMC3426497
EDAT- 2012/06/23 06:00
MHDA- 2012/11/01 06:00
CRDT- 2012/06/23 06:00
PHST- 2012/03/26 00:00 [received]
PHST- 2012/06/21 00:00 [accepted]
PHST- 2012/06/23 06:00 [entrez]
PHST- 2012/06/23 06:00 [pubmed]
PHST- 2012/11/01 06:00 [medline]
AID - 1479-5876-10-129 [pii]
AID - 10.1186/1479-5876-10-129 [doi]
PST - epublish
SO  - J Transl Med. 2012 Jun 21;10:129. doi: 10.1186/1479-5876-10-129.


PMID- 22719853
OWN - NLM
STAT- MEDLINE
DCOM- 20121213
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 6
DP  - 2012
TI  - Results and outcome reporting In ClinicalTrials.gov, what makes it happen?
PG  - e37847
LID - 10.1371/journal.pone.0037847 [doi]
AB  - BACKGROUND: At the end of the past century there were multiple concerns regarding
      lack of transparency in the conduct of clinical trials as well as some ethical
      and scientific issues affecting the trials' design and reporting. In 2000
      ClinicalTrials.gov data repository was developed and deployed to serve public and
      scientific communities with valid data on clinical trials. Later in order to
      increase deposited data completeness and transparency of medical research a set
      of restrains had been imposed making the results deposition compulsory for
      multiple cases. METHODS: We investigated efficiency of the results deposition and
      outcome reporting as well as what factors make positive impact on providing
      information of interest and what makes it more difficult, whether efficiency
      depends on what kind of institution was a trial sponsor. Data from the
      ClinicalTrials.gov repository has been classified based on what kind of
      institution a trial sponsor was. The odds ratio was calculated for results and
      outcome reporting by different sponsors' class. RESULTS: As of 01/01/2012 118,602
      clinical trials data deposits were made to the depository. They came from 9068
      different sources. 35344 (29.8%) of them are assigned as FDA regulated and 25151 
      (21.2%) as Section 801 controlled substances. Despite multiple regulatory
      requirements, only about 35% of trials had clinical study results deposited, the 
      maximum 55.56% of trials with the results, was observed for trials completed in
      2008. CONCLUSIONS: The most positive impact on depositing results, the imposed
      restrains made for hospitals and clinics. Health care companies showed much
      higher efficiency than other investigated classes both in higher fraction of
      trials with results and in providing at least one outcome for their trials. They 
      also more often than others deposit results when it is not strictly required,
      particularly, in the case of non-interventional studies.
FAU - Kirillova, Olga
AU  - Kirillova O
AD  - IICOLL LLC, Portland, Oregon, United States of America. olga@iicoll.com
LA  - eng
PT  - Journal Article
DEP - 20120613
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - *Clinical Trials as Topic
MH  - *Internet
MH  - National Institutes of Health (U.S.)
MH  - Odds Ratio
MH  - *Outcome Assessment, Health Care
MH  - United States
PMC - PMC3374834
EDAT- 2012/06/22 06:00
MHDA- 2012/12/14 06:00
CRDT- 2012/06/22 06:00
PHST- 2012/02/20 00:00 [received]
PHST- 2012/04/25 00:00 [accepted]
PHST- 2012/06/22 06:00 [entrez]
PHST- 2012/06/22 06:00 [pubmed]
PHST- 2012/12/14 06:00 [medline]
AID - 10.1371/journal.pone.0037847 [doi]
AID - PONE-D-12-05158 [pii]
PST - ppublish
SO  - PLoS One. 2012;7(6):e37847. doi: 10.1371/journal.pone.0037847. Epub 2012 Jun 13.


PMID- 22719774
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1687-9678 (Electronic)
VI  - 2012
DP  - 2012
TI  - Amniotic fluid stem cells: future perspectives.
PG  - 741810
LID - 10.1155/2012/741810 [doi]
AB  - The existence of stem cells in human amniotic fluid was reported for the first
      time almost ten years ago. Since this discovery, the knowledge about these cells 
      has increased dramatically. Today, amniotic fluid stem (AFS) cells are widely
      accepted as a new powerful tool for basic research as well as for the
      establishment of new stem-cell-based therapy concepts. It is possible to generate
      monoclonal genomically stable AFS cell lines harboring high proliferative
      potential without raising ethical issues. Many different groups have demonstrated
      that AFS cells can be differentiated into all three germ layer lineages, what is 
      of relevance for both, the scientific and therapeutical usage of these cells. Of 
      special importance for the latter is the fact that AFS cells are less tumorigenic
      than other pluripotent stem cell types. In this paper, we have summarized the
      current knowledge about this relatively young scientific field. Furthermore, we
      discuss the relevant future perspectives of this promising area of stem cell
      research focusing on the next important questions, which need to be answered.
FAU - Rosner, Margit
AU  - Rosner M
AD  - Institute of Medical Genetics, Medical University of Vienna, Wahringer Strasse
      10, 1090 Vienna, Austria.
FAU - Schipany, Katharina
AU  - Schipany K
FAU - Shanmugasundaram, Bharanidharan
AU  - Shanmugasundaram B
FAU - Lubec, Gert
AU  - Lubec G
FAU - Hengstschlager, Markus
AU  - Hengstschlager M
LA  - eng
PT  - Journal Article
DEP - 20120606
PL  - United States
TA  - Stem Cells Int
JT  - Stem cells international
JID - 101535822
PMC - PMC3375114
EDAT- 2012/06/22 06:00
MHDA- 2012/06/22 06:01
CRDT- 2012/06/22 06:00
PHST- 2012/03/02 00:00 [received]
PHST- 2012/04/12 00:00 [accepted]
PHST- 2012/06/22 06:00 [entrez]
PHST- 2012/06/22 06:00 [pubmed]
PHST- 2012/06/22 06:01 [medline]
AID - 10.1155/2012/741810 [doi]
PST - ppublish
SO  - Stem Cells Int. 2012;2012:741810. doi: 10.1155/2012/741810. Epub 2012 Jun 6.


PMID- 22718455
OWN - NLM
STAT- MEDLINE
DCOM- 20120823
LR  - 20211203
IS  - 0393-5590 (Print)
IS  - 0393-5590 (Linking)
VI  - 29
IP  - 3
DP  - 2012 May-Jun
TI  - [Post-renal transplant pregnancy: a project to plan carefully].
PG  - 308-20
AB  - Kidney transplant is the best treatment for end-stage renal disease (ESRD) as it 
      improves the quality of life and reduces the mortality risk for most patients
      compared with maintenance dialysis. Additionally, evidence from the literature
      suggests that renal function, endocrine status and libido rapidly improve after
      kidney transplant, and one in 50 women of childbearing age become pregnant.
      Therefore, it seems clear that pregnancy after transplant is a great challenge
      for physicians involved in this field. The available information on pregnancy
      outcomes is largely derived from case reports and single-center series, which are
      unlikely to be representative. Moreover, poor results are less likely to be
      reported. Many of the reports on long-term outcome show the results of past
      medical, obstetric, and neonatal care, which may be very different from current
      practice. Attempts are being made to provide more up-to-date, representative data
      through national transplantation pregnancy registries. A great number of
      researchers worldwide have analyzed the biological and endocrinological machinery
      associated with this event. Additionally, several strategies have been introduced
      to avoid unplanned pregnancies and to minimize maternal and fetal complications
      in renal transplant recipients. It seems evident that the return to fertility
      soon after transplant is often associated with unplanned pregnancy, which can
      expose both mother and fetus to considerable risks. This underpins the necessity 
      to recommend contraceptive counseling and start clinical follow-up in order to
      early identify possible pregnancy-related risk factors. In general, pregnancy
      should not be recommended within the first year after kidney transplant because
      the risk of acute rejection is greatest and immunosuppressive therapy the most
      aggressive. It should be planned when organ function and immunosuppressive
      therapy are stabilized and there is no sign of rejection, hypertension, or
      chronic infection. Additionally, renal transplant patients and their physicians
      together must try to identify the best timing, carry out pre-pregnancy screening,
      and delineate clinical follow-up and future pharmacological programs to minimize 
      or avoid serious maternal and fetal complications. Finally, additional studies
      are needed to better understand the physiology associated with this condition,
      improve the pharmacological approach, and analyze the complex ethical and social 
      implications of this important aspect of renal transplantation.
FAU - Trubian, Alessandra
AU  - Trubian A
AD  - Sezione di Nefrologia, Dipartimento di Medicina, Universita' di Verona, Azienda
      Ospedaliera Universitaria Integrata, Verona, Italy.
FAU - Zaza, Gianluca
AU  - Zaza G
FAU - Rugiu, Carlo
AU  - Rugiu C
FAU - Tomei, Paola
AU  - Tomei P
FAU - Lupo, Antonio
AU  - Lupo A
LA  - ita
PT  - Journal Article
PT  - Review
TT  - Gravidanza post-trapianto: un progetto da pianificare.
PL  - Italy
TA  - G Ital Nefrol
JT  - Giornale italiano di nefrologia : organo ufficiale della Societa italiana di
      nefrologia
JID - 9426434
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Contraception/methods
MH  - Female
MH  - Graft Rejection/prevention & control
MH  - Humans
MH  - Immunosuppression Therapy/adverse effects
MH  - Immunosuppressive Agents/administration & dosage/adverse effects
MH  - Infant, Newborn
MH  - Kidney Failure, Chronic/*surgery
MH  - *Kidney Transplantation/physiology
MH  - Practice Guidelines as Topic
MH  - Pregnancy
MH  - Pregnancy Complications/prevention & control
MH  - *Pregnancy, Unplanned
MH  - Time Factors
EDAT- 2012/06/22 06:00
MHDA- 2012/08/24 06:00
CRDT- 2012/06/22 06:00
PHST- 2012/06/22 06:00 [entrez]
PHST- 2012/06/22 06:00 [pubmed]
PHST- 2012/08/24 06:00 [medline]
PST - ppublish
SO  - G Ital Nefrol. 2012 May-Jun;29(3):308-20.


PMID- 22718451
OWN - NLM
STAT- MEDLINE
DCOM- 20120823
LR  - 20151119
IS  - 0393-5590 (Print)
IS  - 0393-5590 (Linking)
VI  - 29
IP  - 3
DP  - 2012 May-Jun
TI  - [Monoclonal antibodies in nephrology: a delicate balance between curative
      potential, evidence of effectiveness, and toxicity].
PG  - 283-91; discussion 292
AB  - Rituximab is a chimeric human-murine anti-CD20 monoclonal antibody able to obtain
      the depletion of B lymphocytes. In recent years significant clinical experience
      has been gained and literature studies have been carried out investigating the
      possible role of this drug in autoimmune conditions such as immune-mediated
      glomerulonephritis and transplant rejection. It must be stressed that at present 
      the drug is not registered for any type of kidney disease and its use in
      nephrology is to be considered off-label. A recent report showed that rituximab
      is generously administered in clinical settings where the support of the
      literature is still debated and inconclusive; in a significant number of cases
      the drug is used in contexts where the scientific support can be considered
      substantially inconsistent. This brief report will address the principal findings
      on the use of rituximab in nephrology. It will also briefly evaluate the role of 
      eculizumab, a novel biological drug active on the complement cascade.
      Experimental evidence points to a central role for these two new drugs in many
      immune-mediated conditions of nephrologic interest. This exciting field of
      research is still in its infancy with regard to the scientific assessment of the 
      clinical applications. In view of the ethical considerations concerning the
      toxicity of therapeutic interventions and the need to give patients the best
      available treatment, a great collaborative effort is required by the nephrology
      community to address these clinical issues in the context of multicenter
      randomized controlled studies.
FAU - Magistroni, Riccardo
AU  - Magistroni R
AD  - Divisione di Nefrologia Dialisi e Trapianto, Dipartimento di Medicina, Medicina
      d'Urgenza e Specialita Mediche, Azienda Ospedaliero Universitaria di Modena
      Policlinico, Modena, Italy. riccardo.magistroni@unimore.it
LA  - ita
PT  - English Abstract
PT  - Journal Article
TT  - Anticorpi monoclonali nella clinica nefrologica: il difficile bilancio tra
      prospettive di cura, evidenza dell'efficacia e tossicita.
PL  - Italy
TA  - G Ital Nefrol
JT  - Giornale italiano di nefrologia : organo ufficiale della Societa italiana di
      nefrologia
JID - 9426434
RN  - 0 (Antibodies, Monoclonal, Humanized)
RN  - 0 (Antibodies, Monoclonal, Murine-Derived)
RN  - 0 (Immunologic Factors)
RN  - 4F4X42SYQ6 (Rituximab)
RN  - A3ULP0F556 (eculizumab)
SB  - IM
MH  - Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/drug therapy
MH  - Antibodies, Monoclonal, Humanized/adverse effects/therapeutic use
MH  - Antibodies, Monoclonal, Murine-Derived/adverse effects/*therapeutic use
MH  - Clinical Trials as Topic
MH  - Cryoglobulinemia/drug therapy/immunology
MH  - Glomerulonephritis/*drug therapy/immunology
MH  - Glomerulonephritis, Membranous/drug therapy
MH  - Humans
MH  - Immunologic Factors/adverse effects/*therapeutic use
MH  - Kidney Transplantation/immunology
MH  - Lupus Nephritis/drug therapy/immunology
MH  - Nephrosis, Lipoid/drug therapy
MH  - Rituximab
EDAT- 2012/06/22 06:00
MHDA- 2012/08/24 06:00
CRDT- 2012/06/22 06:00
PHST- 2012/06/22 06:00 [entrez]
PHST- 2012/06/22 06:00 [pubmed]
PHST- 2012/08/24 06:00 [medline]
PST - ppublish
SO  - G Ital Nefrol. 2012 May-Jun;29(3):283-91; discussion 292.


PMID- 22718427
OWN - NLM
STAT- MEDLINE
DCOM- 20130214
LR  - 20211021
IS  - 1573-6814 (Electronic)
IS  - 1389-9333 (Linking)
VI  - 13
IP  - 3
DP  - 2012 Aug
TI  - Beware of the commercialization of human cells and tissues: situation in the
      European Union.
PG  - 487-98
LID - 10.1007/s10561-012-9323-3 [doi]
AB  - With this analysis we would like to raise some issues that emerge as a result of 
      recent evolutions in the burgeoning field of human cells, tissues, and cellular
      and tissue-based product (HCT/P) transplantation, and this in the light of the
      current EU regulatory framework. This paper is intended as an open letter
      addressed to the EU policy makers, who will be charged with the review and
      revision of the current legislation. We propose some urgent corrections or
      additions to cope with the rapid advances in biomedical science, an extensive
      commercialization of HCT/Ps, and the growing expectation of the general public
      regarding the ethical use of altruistically donated cells and tissues. Without a 
      sound wake-up call, the diverging interests of this newly established
      'healthcare' industry and the wellbeing of humanity will likely lead to totally
      unacceptable situations, like some of which we are reporting here.
FAU - Pirnay, Jean-Paul
AU  - Pirnay JP
AD  - Human Cell and Tissue Banks, Laboratory for Molecular and Cellular Technology,
      Burn Wound Centre, Queen Astrid Military Hospital, Brussel, Belgium.
      jean-paul.pirnay@mil.be
FAU - Vanderkelen, Alain
AU  - Vanderkelen A
FAU - Ectors, Nadine
AU  - Ectors N
FAU - Delloye, Christian
AU  - Delloye C
FAU - Dufrane, Denis
AU  - Dufrane D
FAU - Baudoux, Etienne
AU  - Baudoux E
FAU - Van Brussel, Michel
AU  - Van Brussel M
FAU - Casaer, Michael P
AU  - Casaer MP
FAU - De Vos, Daniel
AU  - De Vos D
FAU - Draye, Jean-Pierre
AU  - Draye JP
FAU - Rose, Thomas
AU  - Rose T
FAU - Jennes, Serge
AU  - Jennes S
FAU - Neirinckx, Pierre
AU  - Neirinckx P
FAU - Laire, Geert
AU  - Laire G
FAU - Zizi, Martin
AU  - Zizi M
FAU - Verbeken, Gilbert
AU  - Verbeken G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120621
PL  - Netherlands
TA  - Cell Tissue Bank
JT  - Cell and tissue banking
JID - 100965121
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - European Union
MH  - Humans
MH  - Internationality
MH  - Pharmaceutical Preparations/*economics
MH  - Technology Transfer
MH  - Tissue Banks/*economics
MH  - Transplantation, Homologous/*economics
PMC - PMC3432198
EDAT- 2012/06/22 06:00
MHDA- 2013/02/15 06:00
CRDT- 2012/06/22 06:00
PHST- 2012/04/04 00:00 [received]
PHST- 2012/06/05 00:00 [accepted]
PHST- 2012/06/22 06:00 [entrez]
PHST- 2012/06/22 06:00 [pubmed]
PHST- 2013/02/15 06:00 [medline]
AID - 10.1007/s10561-012-9323-3 [doi]
PST - ppublish
SO  - Cell Tissue Bank. 2012 Aug;13(3):487-98. doi: 10.1007/s10561-012-9323-3. Epub
      2012 Jun 21.


PMID- 22718172
OWN - NLM
STAT- MEDLINE
DCOM- 20121024
LR  - 20120621
IS  - 1119-3077 (Print)
VI  - 15
IP  - 2
DP  - 2012 Apr-Jun
TI  - A cross-sectional study of cutaneous drug reactions in a private dental college
      and government medical college in eastern India.
PG  - 194-8
LID - 10.4103/1119-3077.97317 [doi]
AB  - BACKGROUND: Cutaneous drug reactions are a common impediment in therapy, the
      incidence ranging from 2% to 8%. This cross-sectional study was designed to
      compare different trends of cutaneous drug reaction in two different
      socio-economic groups of patients in the same region. AIMS: The aim was to
      evaluate common drugs implicated in causing reactions, describe the adverse
      cutaneous drug reactions, study the characteristics of patients presenting with
      the reactions. STUDY DESIGN: This is an observational study of cross-sectional
      type. MATERIALS AND METHODS: The study was carried out in the department of Oral 
      and Maxillofacial surgery in a Private dental College and department of General
      Medicine in a Medical College only on outdoor basis for 3 years. Out of 2000
      patients observed in each college for their necessary treatment 75 patients in
      the dental College and 200 patients in the Medical College were reported to have 
      various types of cutaneous drug reactions. Diagnosis was based on detailed
      history including temporal correlation between drug intake and onset of rash and 
      thorough clinical examination Apart from history of drug intake, information
      regarding associated other allergy, comorbidity and severity (whether
      hospitalization was required or not) was recorded. Rechallenge with the drug was 
      not possible due to ethical problem. RESULTS: Out of 2000 patients observed in
      each college 75 patients in dental College and 200 patients in Medical College
      were documented to have different kinds of cutaneous drug reactions. A total of
      30 were male and 45 female in dental college whereas 90 male and 110 female
      patients were enrolled in Medical College. The age group of the patients in both 
      the colleges ranged from 18 to 75 years. Common culprits observed in this study
      were antibiotics and NSAIDs. They had contributed 53% and 40% of the total skin
      reactions respectively in dental college and 47.5% and 45% in Medical College. We
      encountered 6 patients of systemic lupus erythematosus (SLE), 20 patients with
      allergic rhinitis and 12 patients with bronchial asthma in the whole proceedings.
      The duration of drug intake varied from 15 minutes to 2 weeks. The most common
      reaction noted was maculopapular rash 37 (50.5%), urticaria 15 (20%), fixed drug 
      eruption (FDR) 15 (20%), angioedema 6 (8%) in dental College whereas a little
      different trend was observed in the medical college. Hospitalization was required
      in two cases of Steven--Johnson syndrome caused by NSAIDS in the dental College
      whereas 11 patients were hospitalized for the same indication in the medical
      College. Except for maculopapular rash, all other skin reactions were observed
      more frequently with NSAIDS in dental College whereas Steven--Johnson syndrome is
      predominantly observed in Medical College with anticonvulsants. In all the cases 
      causative drugs were withdrawn. A total 40% of the patients required only
      antihistaminic, 35% required antihistaminic and topical corticosteroid and rest
      required a combination of antihistaminic, oral and topical corticosteroids.
      CONCLUSION: Commonest drugs causing drug reactions are antibiotics mainly beta
      lactams and quinolones. Severe reactions were seen in our series with
      anticonvulsants and NSAIDS. Association with other diseases could not be inferred
      due to this modest patient pool.
FAU - Chattopadhyay, C
AU  - Chattopadhyay C
AD  - Department of Pharmacology, KPC Medical College and Hospital, Kolkata, India.
      rivuc2006@gmail.com
FAU - Chakrabarti, N
AU  - Chakrabarti N
LA  - eng
PT  - Journal Article
PL  - India
TA  - Niger J Clin Pract
JT  - Nigerian journal of clinical practice
JID - 101150032
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Anticonvulsants)
RN  - 0 (Antidepressive Agents)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Anti-Bacterial Agents/adverse effects
MH  - Anti-Inflammatory Agents, Non-Steroidal/adverse effects
MH  - Anticonvulsants/adverse effects
MH  - Antidepressive Agents/adverse effects
MH  - Cross-Sectional Studies
MH  - *Dental Clinics
MH  - Drug Eruptions/*epidemiology/etiology
MH  - Female
MH  - *Hospitals, Teaching
MH  - Humans
MH  - India/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Young Adult
EDAT- 2012/06/22 06:00
MHDA- 2012/10/25 06:00
CRDT- 2012/06/22 06:00
PHST- 2012/06/22 06:00 [entrez]
PHST- 2012/06/22 06:00 [pubmed]
PHST- 2012/10/25 06:00 [medline]
AID - NigerJClinPract_2012_15_2_194_97317 [pii]
AID - 10.4103/1119-3077.97317 [doi]
PST - ppublish
SO  - Niger J Clin Pract. 2012 Apr-Jun;15(2):194-8. doi: 10.4103/1119-3077.97317.


PMID- 22718124
OWN - NLM
STAT- MEDLINE
DCOM- 20130506
LR  - 20160518
IS  - 1936-3567 (Electronic)
IS  - 1932-4502 (Linking)
VI  - 46
IP  - 4
DP  - 2012 Dec
TI  - Communism and the meaning of social memory: towards a critical-interpretive
      approach.
PG  - 475-92
LID - 10.1007/s12124-012-9207-x [doi]
AB  - Using a case study of representations of communism in Romania, the paper offers a
      sketch of a critical-interpretive approach for exploring and engaging with the
      social memory of communism. When one considers the various contemporary
      appraisals, responses to and positions towards the communist period one
      identifies and one is obliged to deal with a series of personal and collective
      moral/political quandaries. In their attempt to bring about historical justice,
      political elites create a world that conforms more to their needs and desires
      than to the diversity of meanings of communism, experiences and dilemmas of lay
      people. This paper argues that one needs to study formal aspects of social memory
      as well as "lived", often conflicting, attitudinal and mnemonic stances and
      interpretive frameworks. One needs to strive to find the meaning of the social
      memory of communism in the sometimes contradictory, paradoxical attitudes and
      meanings that members of society communicate, endorse and debate. Many of the
      ethical quandaries and dilemmas of collective memory and recent history can be
      better understood by describing the discursive and sociocultural processes of
      meaning-making and meaning-interpretation carried out by members of a polity.
FAU - Tileaga, Cristian
AU  - Tileaga C
AD  - Discourse and Rhetoric Group, Department of Social Sciences, Loughborough
      University, Loughborough, UK. C.Tileaga@lboro.ac.uk
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - Integr Psychol Behav Sci
JT  - Integrative psychological & behavioral science
JID - 101319534
SB  - IM
MH  - Attitude
MH  - Communism/*history
MH  - Democracy
MH  - History, 20th Century
MH  - Humans
MH  - *Memory
MH  - Public Opinion
MH  - Romania
MH  - Social Conditions
MH  - *Social Environment
EDAT- 2012/06/22 06:00
MHDA- 2013/05/07 06:00
CRDT- 2012/06/22 06:00
PHST- 2012/06/22 06:00 [entrez]
PHST- 2012/06/22 06:00 [pubmed]
PHST- 2013/05/07 06:00 [medline]
AID - 10.1007/s12124-012-9207-x [doi]
PST - ppublish
SO  - Integr Psychol Behav Sci. 2012 Dec;46(4):475-92. doi: 10.1007/s12124-012-9207-x.


PMID- 22718064
OWN - NLM
STAT- MEDLINE
DCOM- 20120928
LR  - 20151221
IS  - 0972-2823 (Electronic)
IS  - 0022-3859 (Linking)
VI  - 58
IP  - 2
DP  - 2012 Apr-Jun
TI  - Will the proposed compensation guidelines for research-related injury spell the
      death knell for clinical research in India?
PG  - 156-8
LID - 10.4103/0022-3859.97243 [doi]
AB  - The Indian Council of Medical Research and the Central Drugs Standards Control
      Organization of the Directorate General of Health Services of the Ministry of
      Health and Family Welfare' draft guidelines for compensation of research-related 
      injury have evoked strong responses from the clinical research community. All
      stakeholders, including academic researchers, teachers in medical colleges, the
      pharmaceutical industry and even members of Institutional Review Boards and
      Ethics Committees have expressed grave reservations about several clauses in the 
      guidelines. Moreover, these two guidelines differ from each other in important
      areas, reiterating that more thought and discussion is necessary to refine the
      guidelines. We present an academic researcher's perspective of the guidelines and
      our views on how they will affect clinical research in the country. The paper
      covers the types of research-related injury that are entitled for compensation,
      controversies on whether injury resulting from standard care should be entitled
      for compensation, whether causality needs to be established as a prerequisite for
      eligibility for compensation and whether all forms of research should have
      mandatory provision for compensation. We also put forward the potential dangers
      of such recommendations, which could potentially be inducement for patients to
      participate in clinical research. Finally, we raise the philosophical issue of
      infringement of an individual's fundamental rights regarding what research he/she
      wishes to participate in. While these points are based on several formal and
      informal discussions with stakeholders from various fields of clinical research, 
      the views expressed are the authors' own personal thoughts.
FAU - Pramesh, C S
AU  - Pramesh CS
AD  - Department of Clinical Research Secretariat and TMC Research Administrative
      Council, Tata Memorial Hospital, Parel, Mumbai, Maharashtra, India.
FAU - Badwe, R A
AU  - Badwe RA
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Postgrad Med
JT  - Journal of postgraduate medicine
JID - 2985196R
SB  - IM
MH  - *Biomedical Research/economics/standards
MH  - *Clinical Trials as Topic/economics/standards
MH  - *Compensation and Redress
MH  - Drug Industry
MH  - Ethics Committees, Research/*standards
MH  - *Government Regulation
MH  - Guidelines as Topic
MH  - Humans
MH  - India
MH  - Informed Consent/ethics
MH  - Research Personnel
EDAT- 2012/06/22 06:00
MHDA- 2012/09/29 06:00
CRDT- 2012/06/22 06:00
PHST- 2012/06/22 06:00 [entrez]
PHST- 2012/06/22 06:00 [pubmed]
PHST- 2012/09/29 06:00 [medline]
AID - jpgm_2012_58_2_156_97243 [pii]
AID - 10.4103/0022-3859.97243 [doi]
PST - ppublish
SO  - J Postgrad Med. 2012 Apr-Jun;58(2):156-8. doi: 10.4103/0022-3859.97243.


PMID- 22718000
OWN - NLM
STAT- MEDLINE
DCOM- 20121009
LR  - 20120621
IS  - 0748-321X (Print)
IS  - 0748-321X (Linking)
VI  - 39
IP  - 2
DP  - 2012 Summer
TI  - Student perceptions of an animal-welfare and ethics course taught early in the
      veterinary curriculum.
PG  - 136-41
LID - 10.3138/jvme.0911.093R1 [doi]
AB  - Animal welfare and veterinary ethics are two subjects that have been acknowledged
      as necessary for inclusion in the veterinary curriculum. In fact, the American
      Veterinary Medical Association (AVMA) Council on Education has mandated that
      veterinary ethics be taught to all students in US veterinary colleges. Animal
      welfare was recently included in the US veterinarian's oath, and AVMA established
      a committee to create a model curriculum on the subject. At US veterinary
      colleges, the number of animal-welfare courses has more than doubled from five in
      2004 to more than 10 in 2011. How and what is taught with regard to these two
      subjects may be as important as whether they are taught at all, and a variety of 
      approaches and varying amounts and types of content are currently being offered
      on them. At Michigan State University's College of Veterinary Medicine, students 
      were introduced to animal welfare and veterinary ethics during their first
      semester in a mandatory two-credit course. To assess their perception of the
      course, students completed an online evaluation at the end of the semester. Most 
      students found the course to be challenging and effective and felt that they
      improved their ability to identify and discuss ethical dilemmas.
FAU - Abood, Sarah K
AU  - Abood SK
AD  - College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA.
      aboodsar@cvm.msu.edu
FAU - Siegford, Janice M
AU  - Siegford JM
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - J Vet Med Educ
JT  - Journal of veterinary medical education
JID - 7610519
SB  - IM
MH  - Animal Welfare/*standards
MH  - Animals
MH  - Bioethical Issues
MH  - Education, Veterinary/*standards
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Michigan
MH  - *Schools, Veterinary
MH  - Students/*psychology
MH  - Veterinary Medicine
EDAT- 2012/06/22 06:00
MHDA- 2012/10/10 06:00
CRDT- 2012/06/22 06:00
PHST- 2012/06/22 06:00 [entrez]
PHST- 2012/06/22 06:00 [pubmed]
PHST- 2012/10/10 06:00 [medline]
AID - 7211371W1J876774 [pii]
AID - 10.3138/jvme.0911.093R1 [doi]
PST - ppublish
SO  - J Vet Med Educ. 2012 Summer;39(2):136-41. doi: 10.3138/jvme.0911.093R1.


PMID- 22717661
OWN - NLM
STAT- MEDLINE
DCOM- 20130910
LR  - 20220409
IS  - 1872-8243 (Electronic)
IS  - 1386-5056 (Linking)
VI  - 82
IP  - 4
DP  - 2013 Apr
TI  - Conceptualising and creating a global learning health system.
PG  - e63-71
LID - 10.1016/j.ijmedinf.2012.05.010 [doi]
LID - S1386-5056(12)00104-9 [pii]
AB  - In any country the health sector is important in terms of human wellbeing and
      large in terms of economics. The health sector might therefore be expected to be 
      a finely tuned enterprise, utilising corporate knowledge in a constant process of
      critically reviewing and improving its activities and processes. However, this is
      seldom the case. Health systems and practice are highly variable and lag behind
      research discovery. This contrasts strongly with commercial bodies, and
      particularly service industries, where the concept of the learning organisation
      is strongly seen as the key to optimisation. A learning organisation accesses for
      analytic purposes operational data, which though captured and recorded for
      day-to-day transactions at the customer level, become also the basis of
      understanding changes in both demand and delivery process. In health care, the
      concept of the learning organisation is well grounded ethically. Anything which
      can improve health, including understanding of optimal care delivery processes
      and how to improve longer term outcomes, should be seized upon to drive service
      improvement - but currently this occurs haphazardly. The limitations of
      paper-based systems, priority given to digitalization of financial transactions, 
      concerns about electronic data insecurity, and other factors have inhibited
      progress towards organisational learning at a national scale. But in recent
      years, new means of capturing, managing, and exchanging data have created new
      opportunities, while ever increasing pressures on health systems have produced
      strengthened incentive. In the United States, the current policy and investment
      impetus to electronic health records and concomitantly their 'meaningful use'
      create opportunities to build the foundations for data re-use for corporate
      learning - and thus for societal gain. In Europe and other settings there are
      islands of innovation, but not yet a coherent culture or impetus to build
      foundations for a learning health system. This paper considers how to move
      forward, in the light of the urgent need for smarter health systems where
      experience becomes the fuel for rapid improvement, and best practices are
      routinely identified and applied.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Friedman, Charles
AU  - Friedman C
AD  - School of Information and Public Health, University of Michigan, Ann Arbor, MI
      48109, USA.
FAU - Rigby, Michael
AU  - Rigby M
LA  - eng
PT  - Journal Article
DEP - 20120618
PL  - Ireland
TA  - Int J Med Inform
JT  - International journal of medical informatics
JID - 9711057
SB  - IM
MH  - Delivery of Health Care/*organization & administration
MH  - Europe
MH  - *Internationality
MH  - *Learning
MH  - United States
EDAT- 2012/06/22 06:00
MHDA- 2013/09/11 06:00
CRDT- 2012/06/22 06:00
PHST- 2011/12/21 00:00 [received]
PHST- 2012/05/21 00:00 [revised]
PHST- 2012/05/21 00:00 [accepted]
PHST- 2012/06/22 06:00 [entrez]
PHST- 2012/06/22 06:00 [pubmed]
PHST- 2013/09/11 06:00 [medline]
AID - S1386-5056(12)00104-9 [pii]
AID - 10.1016/j.ijmedinf.2012.05.010 [doi]
PST - ppublish
SO  - Int J Med Inform. 2013 Apr;82(4):e63-71. doi: 10.1016/j.ijmedinf.2012.05.010.
      Epub 2012 Jun 18.


PMID- 22717406
OWN - NLM
STAT- MEDLINE
DCOM- 20130319
LR  - 20220330
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 19
IP  - 6
DP  - 2012 Nov
TI  - Nonviolent communication: a dialogical retrieval of the ethic of authenticity.
PG  - 829-37
LID - 10.1177/0969733012447016 [doi]
AB  - Charles Taylor called for a retrieval of the ethic of authenticity that has been 
      distorted in modern notions of autonomy and self-fulfillment. Via exchanges with 
      others who matter to us, he proposed that human identities develop through the
      use of rich language draped in shared horizons of significance. The fostering of 
      these dialogical ties beyond purely instrumental purposes, along with the
      recognition of the human dignity in all, may avert the fallen ideal of
      authenticity. Nonviolent communication affords the skillful dialogue with others 
      cradled in a shared sense of significance and supports the development of a
      meaningful identity-one that is formed through the realization of what exists
      beyond the self. The purpose of this article is to argue that nonviolent
      communication facilitates the retrieval of the ethic of authenticity. Narratives 
      from nursing students' journals on the use of nonviolent communication skills
      will be used to support the argument.
FAU - Nosek, Marcianna
AU  - Nosek M
AD  - School of Nursing, University of San Francisco, CA 94117, USA. mnosek@usfca.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120618
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Clinical Competence
MH  - *Communication
MH  - *Ethics, Nursing
MH  - Humans
MH  - Narration
MH  - Students, Nursing
MH  - Violence/*prevention & control
EDAT- 2012/06/22 06:00
MHDA- 2013/03/21 06:00
CRDT- 2012/06/22 06:00
PHST- 2012/06/22 06:00 [entrez]
PHST- 2012/06/22 06:00 [pubmed]
PHST- 2013/03/21 06:00 [medline]
AID - 0969733012447016 [pii]
AID - 10.1177/0969733012447016 [doi]
PST - ppublish
SO  - Nurs Ethics. 2012 Nov;19(6):829-37. doi: 10.1177/0969733012447016. Epub 2012 Jun 
      18.


PMID- 22716653
OWN - NLM
STAT- MEDLINE
DCOM- 20120914
LR  - 20211021
IS  - 1940-4921 (Print)
IS  - 1938-2464 (Linking)
VI  - 5
IP  - 3
DP  - 2012 Jul
TI  - Caregivers' deepest feelings in living with Alzheimer's disease: a Ricoeurian
      interpretation of family caregivers' journals.
PG  - 207-15
LID - 10.3928/19404921-20120605-03 [doi]
AB  - Caring for a person with Alzheimer's disease (AD) challenges family caregivers
      with existential questions about what is the right thing to do for themselves and
      their care recipient. This study extracted themes spontaneously occurring in
      self-disclosure through expressive writing and sheds phenomenological insight
      into the deepest feelings revealed by caregivers of loved ones with AD. The
      personal journals of 24 caregivers were analyzed in the framework of Ricoeur's
      philosophy of ethics based on the concept of personal identity. Caregivers
      reflected on themes in friendship, self-esteem, authenticity, and capacity to act
      with the ethical intention to stay present while the care recipient is
      disappearing. Engaging the text within Ricoeur's ethically sensitive philosophy
      and methodology illuminated the benefit of writing interventions that allow
      caregivers to speak about conflicted states regarding their own humanity in the
      caregiver experience.
CI  - Copyright 2012, SLACK Incorporated.
FAU - Bursch, Heide Christine
AU  - Bursch HC
AD  - The University of Iowa, College of Nursing, Iowa City, IA, USA.
      heide-bursch@uiowa.edu
FAU - Butcher, Howard Karl
AU  - Butcher HK
LA  - eng
GR  - R15 NR008213/NR/NINR NIH HHS/United States
GR  - 1R15NR8213-01/NR/NINR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20120615
PL  - United States
TA  - Res Gerontol Nurs
JT  - Research in gerontological nursing
JID - 101392499
SB  - IM
MH  - *Adaptation, Psychological
MH  - Adult Children/psychology
MH  - Aged
MH  - Aged, 80 and over
MH  - *Alzheimer Disease
MH  - Caregivers/*psychology
MH  - *Emotions
MH  - Female
MH  - Humans
MH  - Iowa
MH  - Male
MH  - Middle Aged
MH  - Spouses/psychology
MH  - Stress, Psychological/psychology
MH  - *Writing
PMC - PMC7437725
MID - NIHMS1588898
EDAT- 2012/06/22 06:00
MHDA- 2012/09/15 06:00
CRDT- 2012/06/22 06:00
PHST- 2011/01/18 00:00 [received]
PHST- 2011/08/19 00:00 [accepted]
PHST- 2012/06/22 06:00 [entrez]
PHST- 2012/06/22 06:00 [pubmed]
PHST- 2012/09/15 06:00 [medline]
AID - 10.3928/19404921-20120605-03 [doi]
PST - ppublish
SO  - Res Gerontol Nurs. 2012 Jul;5(3):207-15. doi: 10.3928/19404921-20120605-03. Epub 
      2012 Jun 15.


PMID- 22716136
OWN - NLM
STAT- MEDLINE
DCOM- 20130325
LR  - 20220129
IS  - 1873-4286 (Electronic)
IS  - 1381-6128 (Linking)
VI  - 18
IP  - 32
DP  - 2012
TI  - Neural mechanisms for the cannabinoid modulation of cognition and affect in man: 
      a critical review of neuroimaging studies.
PG  - 5045-54
AB  - Pharmacological challenge in conjunction with neuroimaging techniques has been
      employed for over two decades now to understand the neural basis of the
      cognitive, emotional and symptomatic effects of the main ingredients of cannabis,
      the most widely used illicit drug in the world. This selective critical review
      focuses on the human neuroimaging studies investigating the effects of delta-9-
      tetrahydrocannabinol (THC) and cannabidiol (CBD), the two main cannabinoids of
      interest present in the extract of the cannabis plant. These studies suggest that
      consistent with the polymorphic and heterogeneous nature of the effects of
      cannabis, THC and CBD have distinct and often opposing effects on widely
      distributed neural networks that include medial temporal and prefrontal cortex
      and striatum, brain regions that are rich in cannabinoid receptors and implicated
      in the pathophysiology of psychosis. They help elucidate the neurocognitive
      mechanisms underlying the acute induction of psychotic symptoms by cannabis and
      provide mechanistic understanding underlying the potential role of CBD as an
      anxiolytic and antipsychotic. Although there are ethical and methodological
      caveats, pharmacological neuroimaging studies such as those reviewed here may not
      only help model different aspects of the psychopathology of mental disorders such
      as schizophrenia and offer insights into their underlying mechanisms, but may
      suggest potentially new therapeutic targets for drug discovery.
FAU - Bhattacharyya, Sagnik
AU  - Bhattacharyya S
AD  - Department of Psychosis Studies, King's College London, Institute of Psychiatry, 
      6th Floor, Main Building, PO Box 067, De Crespigny Park, SE5 8AF, London, UK.
      sagnik.2.bhattacharyya@kcl.ac.uk
FAU - Atakan, Zerrin
AU  - Atakan Z
FAU - Martin-Santos, Rocio
AU  - Martin-Santos R
FAU - Crippa, Jose A
AU  - Crippa JA
FAU - McGuire, Philip K
AU  - McGuire PK
LA  - eng
GR  - NIHR-CS-011-001/DH_/Department of Health/United Kingdom
GR  - G0501775/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Curr Pharm Des
JT  - Current pharmaceutical design
JID - 9602487
RN  - 0 (Cannabinoids)
SB  - IM
MH  - Affect/*drug effects
MH  - Brain/physiopathology
MH  - Cannabinoids/*pharmacology
MH  - Cognition/*drug effects
MH  - Emotions
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Positron-Emission Tomography
EDAT- 2012/06/22 06:00
MHDA- 2013/03/26 06:00
CRDT- 2012/06/22 06:00
PHST- 2012/03/30 00:00 [received]
PHST- 2012/04/17 00:00 [accepted]
PHST- 2012/06/22 06:00 [entrez]
PHST- 2012/06/22 06:00 [pubmed]
PHST- 2013/03/26 06:00 [medline]
AID - CPD-EPUB-20120606-19 [pii]
AID - 10.2174/138161212802884636 [doi]
PST - ppublish
SO  - Curr Pharm Des. 2012;18(32):5045-54. doi: 10.2174/138161212802884636.


PMID- 22715919
OWN - NLM
STAT- MEDLINE
DCOM- 20121015
LR  - 20211021
IS  - 1087-0415 (Electronic)
IS  - 1081-0730 (Linking)
VI  - 17
IP  - 7
DP  - 2012 Aug
TI  - The theory-based influence of map features on risk beliefs: self-reports of what 
      is seen and understood for maps depicting an environmental health hazard.
PG  - 836-56
LID - 10.1080/10810730.2011.650933 [doi]
AB  - Theory-based research is needed to understand how maps of environmental health
      risk information influence risk beliefs and protective behavior. Using
      theoretical concepts from multiple fields of study including visual cognition,
      semiotics, health behavior, and learning and memory supports a comprehensive
      assessment of this influence. The authors report results from 13 cognitive
      interviews that provide theory-based insights into how visual features influenced
      what participants saw and the meaning of what they saw as they viewed 3 formats
      of water test results for private wells (choropleth map, dot map, and a table).
      The unit of perception, color, proximity to hazards, geographic distribution, and
      visual salience had substantial influences on what participants saw and their
      resulting risk beliefs. These influences are explained by theoretical factors
      that shape what is seen, properties of features that shape cognition
      (preattentive, symbolic, visual salience), information processing (top-down and
      bottom-up), and the strength of concrete compared with abstract information.
      Personal relevance guided top-down attention to proximal and larger hazards that 
      shaped stronger risk beliefs. Meaning was more local for small perceptual units
      and global for large units. Three aspects of color were important: preattentive
      "incremental risk" meaning of sequential shading, symbolic safety meaning of
      stoplight colors, and visual salience that drew attention. The lack of imagery,
      geographic information, and color diminished interest in table information.
      Numeracy and prior beliefs influenced comprehension for some participants.
      Results guided the creation of an integrated conceptual framework for application
      to future studies. Ethics should guide the selection of map features that support
      appropriate communication goals.
FAU - Severtson, Dolores J
AU  - Severtson DJ
AD  - School of Nursing, University of Wisconsin-Madison, Clinical Science Center, 600 
      Highland Avenue, Madison, WI 53792, USA. djsevert@wisc.edu
FAU - Vatovec, Christine
AU  - Vatovec C
LA  - eng
GR  - UL1 TR000427/TR/NCATS NIH HHS/United States
GR  - P20 NR008987-04/NR/NINR NIH HHS/United States
GR  - UL1 RR025011/RR/NCRR NIH HHS/United States
GR  - P20 NR008987/NR/NINR NIH HHS/United States
GR  - P20-NR008987/NR/NINR NIH HHS/United States
GR  - 1UL1RR025011/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120620
PL  - United States
TA  - J Health Commun
JT  - Journal of health communication
JID - 9604100
RN  - 0 (Hazardous Substances)
MH  - Adult
MH  - Cognition
MH  - *Environmental Health
MH  - Female
MH  - *Hazardous Substances
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Male
MH  - *Psychological Theory
MH  - Risk Assessment
MH  - Self Report
MH  - Visual Perception
PMC - PMC3656721
MID - NIHMS340301
EDAT- 2012/06/22 06:00
MHDA- 2012/10/16 06:00
CRDT- 2012/06/22 06:00
PHST- 2012/06/22 06:00 [entrez]
PHST- 2012/06/22 06:00 [pubmed]
PHST- 2012/10/16 06:00 [medline]
AID - 10.1080/10810730.2011.650933 [doi]
PST - ppublish
SO  - J Health Commun. 2012 Aug;17(7):836-56. doi: 10.1080/10810730.2011.650933. Epub
      2012 Jun 20.


PMID- 22715619
OWN - NLM
STAT- MEDLINE
DCOM- 20120731
LR  - 20190907
IS  - 1438-3276 (Print)
IS  - 1438-3276 (Linking)
VI  - 154
IP  - 9
DP  - 2012 May 16
TI  - [Billing problems and ethical questions. Personalized cancer therapy: great
      expectations but much is still uncertain].
PG  - 14-5
FAU - Schlingensiepen, Ilse
AU  - Schlingensiepen I
LA  - ger
PT  - News
TT  - Abrechnungsprobleme und ethische Fragen. Personalisierte Krebstherapie: grosse
      Erwartungen, aber vieles ist noch unklar.
PL  - Germany
TA  - MMW Fortschr Med
JT  - MMW Fortschritte der Medizin
JID - 100893959
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Antineoplastic Agents/*therapeutic use
MH  - Biomarkers, Tumor/blood
MH  - *Ethics, Medical
MH  - Germany
MH  - Humans
MH  - National Health Programs/*ethics
MH  - Neoplasms/diagnosis/*drug therapy
MH  - Precision Medicine/*ethics
MH  - Reimbursement Mechanisms/*ethics
MH  - Resource Allocation/ethics
MH  - Treatment Outcome
EDAT- 2012/06/22 06:00
MHDA- 2012/08/01 06:00
CRDT- 2012/06/22 06:00
PHST- 2012/06/22 06:00 [entrez]
PHST- 2012/06/22 06:00 [pubmed]
PHST- 2012/08/01 06:00 [medline]
AID - 10.1007/s15006-012-0559-4 [doi]
PST - ppublish
SO  - MMW Fortschr Med. 2012 May 16;154(9):14-5. doi: 10.1007/s15006-012-0559-4.


PMID- 22713356
OWN - NLM
STAT- MEDLINE
DCOM- 20121009
LR  - 20220310
IS  - 1758-2652 (Electronic)
IS  - 1758-2652 (Linking)
VI  - 15 Suppl 1
DP  - 2012 Jun 14
TI  - How a masculine work ethic and economic circumstances affect uptake of HIV
      treatment: experiences of men from an artisanal gold mining community in rural
      eastern Uganda.
PG  - 1-9
LID - 10.7448/IAS.15.3.17368 [doi]
AB  - BACKGROUND: Current data from Uganda indicate that, compared to women, men are
      under-represented in HIV treatment, seek treatment later and have a higher
      mortality while on antiretroviral therapy (ART). By focusing on a masculine work 
      ethic as one of the most predominant expressions of masculinity, this study
      explores why for some men HIV treatment enhances their masculinity while for
      others it undermines masculine work identity, leading them to discontinue the
      treatment. METHODS: Participant observation and 26 in-depth interviews with men
      were conducted in a gold mining village in Eastern Uganda between August 2009 and
      August 2010. Interviewees included men who were taking HIV treatment, who had
      discontinued treatment, who suspected HIV infection but had not sought testing,
      or who had other symptoms unrelated to HIV infection. RESULTS: Many participants 
      reported spending large proportions of their income, alleviating symptoms prior
      to confirming their HIV infection. This seriously undermined their sense of
      masculinity gained from providing for their families. Disclosing HIV diagnosis
      and treatment to employers and work colleagues could reduce job offers and/or
      collaborative work, as colleagues feared working with "ill" people. Drug
      side-effects affected work, leading some men to discontinue the treatment.
      Despite being on ART, some men believed their health remained fragile, leading
      them to opt out of hard work, contradicting their reputation as hard workers.
      However, some men on treatment talked about "resurrecting" due to ART and linked 
      their current abilities to work again to good adherence. For some men, it was
      work colleagues who suggested testing and treatment-seeking following symptoms.
      CONCLUSIONS: The central role of a work ethic in expressing masculinity can both 
      encourage and discourage men's treatment-seeking for AIDS. HIV testing and
      treatment may be sought in order to improve health and get back to work, thereby 
      in the process regaining one's masculine reputation as a hard worker and provider
      for one's family. However, disclosure can affect opportunities for work and drug 
      side-effects disrupt one's ability to labour, undermining the sense of
      masculinity gained from work. HIV support organizations need to recognize how
      economic and gender concerns impact on treatment decisions and help men deal with
      work-related fears.
FAU - Siu, Godfrey E
AU  - Siu GE
AD  - MRC Social and Public Health Sciences Unit, University of Glasgow, Glasgow, UK.
      godfrey@sphsu.mrc.ac.uk
FAU - Wight, Daniel
AU  - Wight D
FAU - Seeley, Janet
AU  - Seeley J
LA  - eng
GR  - MC_U950097154/MRC_/Medical Research Council/United Kingdom
GR  - MC_UP_A540_1108/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120614
PL  - Switzerland
TA  - J Int AIDS Soc
JT  - Journal of the International AIDS Society
JID - 101478566
RN  - 7440-57-5 (Gold)
SB  - IM
MH  - Adult
MH  - Gold
MH  - HIV Infections/*drug therapy
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - *Masculinity
MH  - Middle Aged
MH  - Mining
MH  - Patient Acceptance of Health Care/*psychology
MH  - Rural Population
MH  - Uganda
PMC - PMC3499901
EDAT- 2012/06/22 06:00
MHDA- 2012/10/10 06:00
CRDT- 2012/06/21 06:00
PHST- 2012/01/09 00:00 [received]
PHST- 2012/03/20 00:00 [revised]
PHST- 2012/04/29 00:00 [accepted]
PHST- 2012/06/21 06:00 [entrez]
PHST- 2012/06/22 06:00 [pubmed]
PHST- 2012/10/10 06:00 [medline]
AID - 17368 [pii]
AID - 10.7448/IAS.15.3.17368 [doi]
PST - epublish
SO  - J Int AIDS Soc. 2012 Jun 14;15 Suppl 1:1-9. doi: 10.7448/IAS.15.3.17368.


PMID- 22713355
OWN - NLM
STAT- MEDLINE
DCOM- 20121009
LR  - 20211021
IS  - 1758-2652 (Electronic)
IS  - 1758-2652 (Linking)
VI  - 15 Suppl 1
DP  - 2012 Jun 14
TI  - HIV prevention, structural change and social values: the need for an explicit
      normative approach.
PG  - 1-10
LID - 10.7448/IAS.15.3.17367 [doi]
AB  - BACKGROUND: The fact that HIV prevention often deals with politicised sexual and 
      drug taking behaviour is well known, but structural HIV prevention interventions 
      in particular can involve alteration of social arrangements over which there may 
      be further contested values at stake. As such, normative frameworks are required 
      to inform HIV prevention decisions and avoid conflicts between social goals.
      METHODS: This paper provides a conceptual review and discussion of the normative 
      issues surrounding structural HIV prevention strategies. It applies political and
      ethical concepts to explore the contested nature of HIV planning and suggests
      conceptual frameworks to inform future structural HIV responses. RESULTS: HIV
      prevention is an activity that cannot be pursued without making value judgements;
      it is inherently political. Appeals to health outcomes alone are insufficient
      when intervention strategies have broader social impacts, or when incidence
      reduction can be achieved at the expense of other social values such as freedom, 
      equality, or economic growth. This is illustrated by the widespread
      unacceptability of forced isolation which may be efficacious in preventing spread
      of infectious agents, but conflicts with other social values. CONCLUSIONS: While 
      no universal value system exists, the capability approach provides one potential 
      framework to help overcome seeming contradictions or value trade-offs in
      structural HIV prevention approaches. However, even within the capability
      approach, valuations must still be made. Making normative values explicit in
      decision making processes is required to ensure transparency, accountability, and
      representativeness of the public interest, while ensuring structural HIV
      prevention efforts align with broader social development goals as well.
FAU - Parkhurst, Justin O
AU  - Parkhurst JO
AD  - Department of Global Health and Development, London School of Hygiene and
      Tropical Medicine, London, United Kingdom. justin.parkhurst@lshtm.ac.uk.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120614
PL  - Switzerland
TA  - J Int AIDS Soc
JT  - Journal of the International AIDS Society
JID - 101478566
SB  - IM
MH  - Communicable Disease Control/*methods
MH  - HIV Infections/*epidemiology/*prevention & control
MH  - Health Services Needs and Demand/trends
MH  - Humans
MH  - Social Change
MH  - Social Values
PMC - PMC3499876
EDAT- 2012/06/22 06:00
MHDA- 2012/10/10 06:00
CRDT- 2012/06/21 06:00
PHST- 2012/01/13 00:00 [received]
PHST- 2012/04/01 00:00 [revised]
PHST- 2012/04/29 00:00 [accepted]
PHST- 2012/06/21 06:00 [entrez]
PHST- 2012/06/22 06:00 [pubmed]
PHST- 2012/10/10 06:00 [medline]
AID - 17367 [pii]
AID - 10.7448/IAS.15.3.17367 [doi]
PST - epublish
SO  - J Int AIDS Soc. 2012 Jun 14;15 Suppl 1:1-10. doi: 10.7448/IAS.15.3.17367.


PMID- 22709900
OWN - NLM
STAT- MEDLINE
DCOM- 20120823
LR  - 20160523
IS  - 2212-2672 (Print)
IS  - 2212-2672 (Linking)
VI  - 112
IP  - 5 Suppl
DP  - 2012 May
TI  - Ethical practice in foodservice management.
PG  - S41-2
LID - 10.1016/j.jand.2012.03.016 [doi]
FAU - Barkley, William C
AU  - Barkley WC
AD  - The Children's Mercy Hospitals and Clinics, Kansas City, MO, USA.
LA  - eng
PT  - Journal Article
DEP - 20120420
PL  - United States
TA  - J Acad Nutr Diet
JT  - Journal of the Academy of Nutrition and Dietetics
JID - 101573920
SB  - IM
MH  - Dietetics/*ethics
MH  - *Ethics, Professional
MH  - Food Services/*ethics
MH  - Humans
MH  - United States
EDAT- 2012/06/22 06:00
MHDA- 2012/08/24 06:00
CRDT- 2012/06/20 06:00
PHST- 2006/11/29 00:00 [accepted]
PHST- 2012/06/20 06:00 [entrez]
PHST- 2012/06/22 06:00 [pubmed]
PHST- 2012/08/24 06:00 [medline]
AID - S2212-2672(12)00332-2 [pii]
AID - 10.1016/j.jand.2012.03.016 [doi]
PST - ppublish
SO  - J Acad Nutr Diet. 2012 May;112(5 Suppl):S41-2. doi: 10.1016/j.jand.2012.03.016.
      Epub 2012 Apr 20.


PMID- 22709899
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20160523
IS  - 2212-2672 (Print)
IS  - 2212-2672 (Linking)
VI  - 112
IP  - 5 Suppl
DP  - 2012 May
TI  - Management matters.
PG  - S38-40
LID - 10.1016/j.jand.2012.03.018 [doi]
AB  - Fewer than 50% of registered dietitians (RDs) supervise personnel and 76% have no
      budget authority. Because higher salaries are tied to increasing levels of
      authority and responsibility, RDs must seek management and leadership roles to
      enjoy the increased remuneration tied to such positions. Advanced-level practice 
      in any area of dietetics demands powerful communication abilities, proficiency in
      budgeting and finance, comfort with technology, higher-order
      decision-making/problem-solving skills, and well-honed human resource management 
      capabilities, all foundational to competent management practice. As RDs envision 
      the future of the dietetics profession, practitioners must evaluate management
      competence in both hard and soft skills. Just as research is needed to support
      evidenced-based clinical practice, the same is needed to support management
      practice across the profession. Dietetics educators and preceptors should be as
      enthusiastic about management practice as they are clinical practice when
      educating and mentoring future professionals. Such encouragement and support can 
      mean that new RDs and dietetic technicians, registered, will understand what it
      takes to advance to higher levels of responsibility, authority, and subsequent
      enhanced remuneration. In the ever-changing social, legal, ethical, political,
      economic, technological, and ecological environments of work, food and nutrition 
      professionals who are willing to step forward and assume the risks and
      responsibilities of management also will share in the rewards, and propel the
      profession to new heights of recognition and respect.
CI  - Copyright (c) 2012. Published by Elsevier Inc.
FAU - Gould, Rebecca A
AU  - Gould RA
AD  - Information Technology Assistance Center, Kansas State University, Manhattan, KS 
      66506, USA. ragou@k-state.edu
FAU - Canter, Deborah
AU  - Canter D
LA  - eng
PT  - Journal Article
DEP - 20120420
PL  - United States
TA  - J Acad Nutr Diet
JT  - Journal of the Academy of Nutrition and Dietetics
JID - 101573920
RPF - J Am Diet Assoc. 2008 Nov;108(11):1834-6. PMID: 18954571
EDAT- 2012/06/22 06:00
MHDA- 2012/06/22 06:01
CRDT- 2012/06/20 06:00
PHST- 2008/03/23 00:00 [accepted]
PHST- 2012/06/20 06:00 [entrez]
PHST- 2012/06/22 06:00 [pubmed]
PHST- 2012/06/22 06:01 [medline]
AID - S2212-2672(12)00334-6 [pii]
AID - 10.1016/j.jand.2012.03.018 [doi]
PST - ppublish
SO  - J Acad Nutr Diet. 2012 May;112(5 Suppl):S38-40. doi: 10.1016/j.jand.2012.03.018. 
      Epub 2012 Apr 20.


PMID- 22715020
OWN - NLM
STAT- MEDLINE
DCOM- 20130919
LR  - 20131121
IS  - 1097-0347 (Electronic)
IS  - 1043-3074 (Linking)
VI  - 35
IP  - 4
DP  - 2013 Apr
TI  - Parathyroid function after open thyroidectomy: A prospective randomized study for
      ligasure precise versus harmonic FOCUS.
PG  - 562-7
LID - 10.1002/hed.23005 [doi]
AB  - BACKGROUND: Options for controlling hemostasis during thyroidectomy include
      bipolar vessel sealing system and ultrasonic technology. The purpose of this
      study was to compare these energy-based devices on the performance of open
      thyroidectomy for benign disease with emphasis given to postoperative parathyroid
      function. METHODS: Among the available energy-based devices, the LigaSure Precise
      (LP; Valleylab, Boulder, CO) and FOCUS Shears (FS; Ethicon Endo-Surgery,
      Cincinnati, OH) were evaluated. One hundred ninety-nine consecutive patients
      scheduled for open thyroidectomy were prospectively randomized into 2
      similar-sized groups. Operative time, morbidity, incision length, postoperative
      pain, and hospital stay were analyzed. Postoperative hypoparathyroidism was
      monitored with serial determinations of intact parathyroid hormone (iPTH) and
      serum calcium. RESULTS: Early postoperative measurement of iPTH plasma level,
      although within the reference range, was significantly lower in the FS group (p <
      .001). Oral calcium supplementation was significantly higher and prolonged in the
      FS group. CONCLUSION: The present study demonstrates a significant difference of 
      the rates for postoperative parathyroid malfunction when using different
      energy-based devices.
CI  - Copyright (c) 2012 Wiley Periodicals, Inc.
FAU - Dionigi, Gianlorenzo
AU  - Dionigi G
AD  - Department of Surgical Sciences, University of Insubria, Varese-Como, Italy.
      gianlorenzo.dionigi@uninsubria.it
FAU - Van Slycke, Sam
AU  - Van Slycke S
FAU - Rausei, Stefano
AU  - Rausei S
FAU - Boni, Luigi
AU  - Boni L
FAU - Dionigi, Renzo
AU  - Dionigi R
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20120619
PL  - United States
TA  - Head Neck
JT  - Head & neck
JID - 8902541
RN  - 0 (Parathyroid Hormone)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Blood Loss, Surgical
MH  - Calcium/blood
MH  - Female
MH  - Hemostasis, Surgical/*instrumentation
MH  - Humans
MH  - Hypoparathyroidism/epidemiology/*etiology
MH  - Ligation/instrumentation
MH  - Male
MH  - Middle Aged
MH  - Parathyroid Glands/*surgery
MH  - Parathyroid Hormone/*blood
MH  - Postoperative Complications/epidemiology/*etiology
MH  - Prospective Studies
MH  - Thyroidectomy/*instrumentation
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2012/06/21 06:00
MHDA- 2013/09/21 06:00
CRDT- 2012/06/21 06:00
PHST- 2012/02/02 00:00 [accepted]
PHST- 2012/06/21 06:00 [entrez]
PHST- 2012/06/21 06:00 [pubmed]
PHST- 2013/09/21 06:00 [medline]
AID - 10.1002/hed.23005 [doi]
PST - ppublish
SO  - Head Neck. 2013 Apr;35(4):562-7. doi: 10.1002/hed.23005. Epub 2012 Jun 19.


PMID- 22714850
OWN - NLM
STAT- MEDLINE
DCOM- 20121130
LR  - 20170225
IS  - 1808-8686 (Electronic)
IS  - 1808-8686 (Linking)
VI  - 78
IP  - 3
DP  - 2012 Jun
TI  - Bioethics and medical/legal considerations on cochlear implants in children.
PG  - 70-9
LID - S1808-86942012000300013 [pii]
AB  - UNLABELLED: Cochlear implants are the best treatment for congenital profound
      deafness. Pediatric candidates to implantation are seen as vulnerable citizens,
      and the decision of implanting cochlear devices is ultimately in the hands of
      their parents/guardians. The Brazilian Penal Code dictates that deaf people may
      enjoy diminished criminal capacity. Many are the bioethical controversies around 
      cochlear implants, as representatives from the deaf community have seen in them a
      means of decimating their culture and intrinsic values. OBJECTIVE: This paper
      aims to discuss, in bioethical terms, the validity of implanting cochlear hearing
      aids in children by analyzing their vulnerability and the social/cultural
      implications of the procedure itself, aside from looking into the medical/legal
      aspects connected to their criminal capacity. MATERIALS AND METHODS: The topic
      was searched on databases Medline and Lilacs; ethical analysis was done based on 
      principialist bioethics. RESULTS: Cochlear implants are the best therapeutic
      option for people with profound deafness and are morally justified. The level of 
      criminal capacity attributed to deaf people requires careful analysis of the
      subject's degree of understanding and determination when carrying out the acts
      for which he/she has been charged. CONCLUSION: Cochlear implants are morally
      valid. Implantations must be analyzed on an each case basis. ENT physicians bear 
      the ethical responsibility for indicating cochlear implants and must properly
      inform the child's parents/guardians and get their written consent before
      performing the procedure.
FAU - Miziara, Ivan Dieb
AU  - Miziara ID
AD  - Medical School of ABC.
FAU - Miziara, Carmen Silvia Molleis Galego
AU  - Miziara CS
FAU - Tsuji, Robson Koji
AU  - Tsuji RK
FAU - Bento, Ricardo Ferreira
AU  - Bento RF
LA  - eng
LA  - por
PT  - Journal Article
PL  - Brazil
TA  - Braz J Otorhinolaryngol
JT  - Brazilian journal of otorhinolaryngology
JID - 101207337
SB  - IM
MH  - Bioethical Issues
MH  - Brazil
MH  - Child
MH  - Cochlear Implantation/*ethics
MH  - Cochlear Implants/*ethics
MH  - Cultural Characteristics
MH  - Deafness/*surgery
MH  - Humans
MH  - Informed Consent
MH  - Otolaryngology/*ethics/*legislation & jurisprudence
MH  - Parent-Child Relations
MH  - Social Values
EDAT- 2012/06/21 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/06/21 06:00
PHST- 2011/08/19 00:00 [received]
PHST- 2012/01/03 00:00 [accepted]
PHST- 2012/06/21 06:00 [entrez]
PHST- 2012/06/21 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - S1808-8694(15)30247-0 [pii]
PST - ppublish
SO  - Braz J Otorhinolaryngol. 2012 Jun;78(3):70-9.


PMID- 22713814
OWN - NLM
STAT- MEDLINE
DCOM- 20130520
LR  - 20211021
IS  - 1476-5438 (Electronic)
IS  - 1018-4813 (Linking)
VI  - 21
IP  - 1
DP  - 2013 Jan
TI  - Developing a policy for paediatric biobanks: principles for good practice.
PG  - 2-7
LID - 10.1038/ejhg.2012.99 [doi]
AB  - The participation of minors in biobank research can offer great benefits for
      science and health care. However, as minors are a vulnerable population they are 
      also in need of adequate protective measures when they are enrolled in research. 
      Research using biobanked biological samples from children poses additional
      ethical issues to those raised by research using adult biobanks. For example,
      small children have only limited capacity, if any, to understand the meaning and 
      implications of the research and to give a documented agreement to it. Older
      minors are gradually acquiring this capacity. We describe principles for good
      practice related to the inclusion of minors in biobank research, focusing on
      issues related to benefits and subsidiarity, consent, proportionality and return 
      of results. Some of these issues are currently heavily debated, and we conclude
      by providing principles for good practice for policy makers of biobanks,
      researchers and anyone involved in dealing with stored tissue samples from
      children. Actual implementation of the principles will vary according to
      different jurisdictions.
FAU - Hens, Kristien
AU  - Hens K
AD  - Health, Ethics and Society, Maastricht University, Maastricht, The Netherlands.
      k.hens@maastrichtuniversity.nl
FAU - Van El, Carla E
AU  - Van El CE
FAU - Borry, Pascal
AU  - Borry P
FAU - Cambon-Thomsen, Anne
AU  - Cambon-Thomsen A
FAU - Cornel, Martina C
AU  - Cornel MC
FAU - Forzano, Francesca
AU  - Forzano F
FAU - Lucassen, Anneke
AU  - Lucassen A
FAU - Patch, Christine
AU  - Patch C
FAU - Tranebjaerg, Lisbeth
AU  - Tranebjaerg L
FAU - Vermeulen, Eric
AU  - Vermeulen E
FAU - Salvaterra, Elena
AU  - Salvaterra E
FAU - Tibben, Aad
AU  - Tibben A
FAU - Dierickx, Kris
AU  - Dierickx K
CN  - PPPC of the European Society of Human Genetics
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120620
PL  - England
TA  - Eur J Hum Genet
JT  - European journal of human genetics : EJHG
JID - 9302235
SB  - IM
MH  - Biological Specimen Banks/*ethics/legislation & jurisprudence
MH  - Child
MH  - Clinical Trials as Topic/ethics
MH  - Europe
MH  - Genetic Research/ethics
MH  - Humans
MH  - Informed Consent/ethics
MH  - *Minors
PMC - PMC3533257
IR  - Borry P
FIR - Borry, P
IR  - Cambon-Thomsen A
FIR - Cambon-Thomsen, A
IR  - Cornel MC
FIR - Cornel, M C
IR  - Fellmann F
FIR - Fellmann, F
IR  - Forzano F
FIR - Forzano, F
IR  - Hodgson S
FIR - Hodgson, S
IR  - Howard H
FIR - Howard, H
IR  - Kayserili H
FIR - Kayserili, H
IR  - Patch C
FIR - Patch, C
IR  - Peterlin B
FIR - Peterlin, B
IR  - Rogowski W
FIR - Rogowski, W
IR  - Sequeiros J
FIR - Sequeiros, J
IR  - Soller M
FIR - Soller, M
IR  - Tibben A
FIR - Tibben, A
IR  - Tranebjaerg L
FIR - Tranebjaerg, L
EDAT- 2012/06/21 06:00
MHDA- 2013/05/22 06:00
CRDT- 2012/06/21 06:00
PHST- 2012/06/21 06:00 [entrez]
PHST- 2012/06/21 06:00 [pubmed]
PHST- 2013/05/22 06:00 [medline]
AID - ejhg201299 [pii]
AID - 10.1038/ejhg.2012.99 [doi]
PST - ppublish
SO  - Eur J Hum Genet. 2013 Jan;21(1):2-7. doi: 10.1038/ejhg.2012.99. Epub 2012 Jun 20.


PMID- 22713808
OWN - NLM
STAT- MEDLINE
DCOM- 20130319
LR  - 20220129
IS  - 1476-5438 (Electronic)
IS  - 1018-4813 (Linking)
VI  - 20
IP  - 11
DP  - 2012 Nov
TI  - Toward a roadmap in global biobanking for health.
PG  - 1105-11
LID - 10.1038/ejhg.2012.96 [doi]
AB  - Biobanks can have a pivotal role in elucidating disease etiology, translation,
      and advancing public health. However, meeting these challenges hinges on a
      critical shift in the way science is conducted and requires biobank
      harmonization. There is growing recognition that a common strategy is imperative 
      to develop biobanking globally and effectively. To help guide this strategy, we
      articulate key principles, goals, and priorities underpinning a roadmap for
      global biobanking to accelerate health science, patient care, and public health. 
      The need to manage and share very large amounts of data has driven innovations on
      many fronts. Although technological solutions are allowing biobanks to reach new 
      levels of integration, increasingly powerful data-collection tools, analytical
      techniques, and the results they generate raise new ethical and legal issues and 
      challenges, necessitating a reconsideration of previous policies, practices, and 
      ethical norms. These manifold advances and the investments that support them are 
      also fueling opportunities for biobanks to ultimately become integral parts of
      health-care systems in many countries. International harmonization to increase
      interoperability and sustainability are two strategic priorities for biobanking. 
      Tackling these issues requires an environment favorably inclined toward
      scientific funding and equipped to address socio-ethical challenges. Cooperation 
      and collaboration must extend beyond systems to enable the exchange of data and
      samples to strategic alliances between many organizations, including governmental
      bodies, funding agencies, public and private science enterprises, and other
      stakeholders, including patients. A common vision is required and we articulate
      the essential basis of such a vision herein.
FAU - Harris, Jennifer R
AU  - Harris JR
AD  - Department of Genes and Environment, Division of Epidemiology, The Norwegian
      Institute of Public Health, Oslo, Norway. Jennifer.harris@fhi.no
FAU - Burton, Paul
AU  - Burton P
FAU - Knoppers, Bartha Maria
AU  - Knoppers BM
FAU - Lindpaintner, Klaus
AU  - Lindpaintner K
FAU - Bledsoe, Marianna
AU  - Bledsoe M
FAU - Brookes, Anthony J
AU  - Brookes AJ
FAU - Budin-Ljosne, Isabelle
AU  - Budin-Ljosne I
FAU - Chisholm, Rex
AU  - Chisholm R
FAU - Cox, David
AU  - Cox D
FAU - Deschenes, Mylene
AU  - Deschenes M
FAU - Fortier, Isabel
AU  - Fortier I
FAU - Hainaut, Pierre
AU  - Hainaut P
FAU - Hewitt, Robert
AU  - Hewitt R
FAU - Kaye, Jane
AU  - Kaye J
FAU - Litton, Jan-Eric
AU  - Litton JE
FAU - Metspalu, Andres
AU  - Metspalu A
FAU - Ollier, Bill
AU  - Ollier B
FAU - Palmer, Lyle J
AU  - Palmer LJ
FAU - Palotie, Aarno
AU  - Palotie A
FAU - Pasterk, Markus
AU  - Pasterk M
FAU - Perola, Markus
AU  - Perola M
FAU - Riegman, Peter H J
AU  - Riegman PH
FAU - van Ommen, Gert-Jan
AU  - van Ommen GJ
FAU - Yuille, Martin
AU  - Yuille M
FAU - Zatloukal, Kurt
AU  - Zatloukal K
LA  - eng
GR  - 096599/Wellcome Trust/United Kingdom
GR  - 096599/2/11/Z/WT_/Wellcome Trust/United Kingdom
GR  - G0600237/MRC_/Medical Research Council/United Kingdom
GR  - G0100594/MRC_/Medical Research Council/United Kingdom
GR  - G0901461/MRC_/Medical Research Council/United Kingdom
GR  - G0900753/MRC_/Medical Research Council/United Kingdom
GR  - Wellcome Trust/United Kingdom
GR  - # 200754/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120620
PL  - England
TA  - Eur J Hum Genet
JT  - European journal of human genetics : EJHG
JID - 9302235
SB  - IM
MH  - Biological Specimen Banks/ethics/legislation & jurisprudence/*organization &
      administration/trends
MH  - Data Collection
MH  - Databases, Factual
PMC - PMC3477856
EDAT- 2012/06/21 06:00
MHDA- 2013/03/21 06:00
CRDT- 2012/06/21 06:00
PHST- 2012/06/21 06:00 [entrez]
PHST- 2012/06/21 06:00 [pubmed]
PHST- 2013/03/21 06:00 [medline]
AID - ejhg201296 [pii]
AID - 10.1038/ejhg.2012.96 [doi]
PST - ppublish
SO  - Eur J Hum Genet. 2012 Nov;20(11):1105-11. doi: 10.1038/ejhg.2012.96. Epub 2012
      Jun 20.


PMID- 22712887
OWN - NLM
STAT- MEDLINE
DCOM- 20150622
LR  - 20211021
IS  - 1369-7625 (Electronic)
IS  - 1369-6513 (Linking)
VI  - 17
IP  - 5
DP  - 2014 Oct
TI  - Patient advocacy and patient centredness in participant recruitment to
      randomized-controlled trials: implications for informed consent.
PG  - 670-82
LID - 10.1111/j.1369-7625.2012.00792.x [doi]
AB  - CONTEXT: With the routinization of evidence-based medicine and of the
      randomized-controlled trial (RCT), more patients are becoming 'sites of evidence 
      production' yet, little is known about how they are recruited as participants;
      there is some evidence that 'substantively valid consent' is difficult to
      achieve. OBJECTIVE: To explore the views and experiences of nurses recruiting
      patients to randomized-controlled trials and to examine the extent to which their
      recruitment practices were patient-centred and patient empowering. DESIGN:
      Semi-structured in-depth interviews; audio recording of recruitment appointments;
      thematic interactional analysis (drawing on discourse and conversation analysis).
      SETTING AND PARTICIPANTS: Nurses recruiting patients to five publicly funded RCTs
      and patients consenting to the recording of their recruitment sessions. MAIN
      OUTCOME MEASURES: The views of recruiting nurses about their recruitment role;
      the extent to which nurse-patient interactions were patient-centred; the nature
      of the nurses' interactional strategies and the nature and extent of patient
      participation in the discussion. RESULTS: The nurses had a keen sense of
      themselves as clinicians and patient advocates and their perceptions of the trial
      and its interventions were inextricably linked to those of the patients. However,
      many of their recruitment practices made it difficult for patients to play an
      active and informed part in the discussion about trial participation, raising
      questions over the quality of consent decisions. CONCLUSION: Nurses working in
      patient recruitment to RCTs need to reconcile two different worlds with different
      demands and ethics. Evidence production, a central task in evidence-based
      medicine, poses a challenge to patient-centred practice and more research and
      relevant training are needed.
CI  - (c) 2012 John Wiley & Sons Ltd.
FAU - Tomlin, Zelda
AU  - Tomlin Z
AD  - Research Fellow, Department of Primary Care and Public Health, Cardiff
      University, CardiffResearch Fellow, School of Social and Community Medicine,
      University of Bristol, BristolResearch Fellow RCUK, Department of Sociology,
      University of York, York.
FAU - deSalis, Isabel
AU  - deSalis I
FAU - Toerien, Merran
AU  - Toerien M
FAU - Donovan, Jenny L
AU  - Donovan JL
LA  - eng
GR  - G0800800/MRC_/Medical Research Council/United Kingdom
GR  - MC_U145079312/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120619
PL  - England
TA  - Health Expect
JT  - Health expectations : an international journal of public participation in health 
      care and health policy
JID - 9815926
SB  - IM
MH  - Humans
MH  - *Informed Consent/ethics
MH  - Interviews as Topic
MH  - Nurse-Patient Relations
MH  - Nurses
MH  - *Patient Advocacy
MH  - *Patient Selection/ethics
MH  - *Patient-Centered Care
MH  - Randomized Controlled Trials as Topic/ethics/*methods
PMC - PMC5060918
OTO - NOTNLM
OT  - informed consent
OT  - patient advocacy
OT  - patient recruitment
OT  - professional-patient
OT  - randomized controlled trial
OT  - relations
OT  - shared decision-making
EDAT- 2012/06/21 06:00
MHDA- 2015/06/24 06:00
CRDT- 2012/06/21 06:00
PHST- 2012/06/21 06:00 [entrez]
PHST- 2012/06/21 06:00 [pubmed]
PHST- 2015/06/24 06:00 [medline]
AID - 10.1111/j.1369-7625.2012.00792.x [doi]
PST - ppublish
SO  - Health Expect. 2014 Oct;17(5):670-82. doi: 10.1111/j.1369-7625.2012.00792.x. Epub
      2012 Jun 19.


PMID- 22712743
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20120620
IS  - 1747-4949 (Electronic)
IS  - 1747-4930 (Linking)
VI  - 7
IP  - 5
DP  - 2012 Jul
TI  - The use of animal as models: ethical considerations.
PG  - 440-2
LID - 10.1111/j.1747-4949.2012.00772.x [doi]
AB  - The use of animals in scientific research is highly controversial. Older
      justifications, which referred to an immense gulf between human beings and other 
      animals, can no longer be sustained in the face of a large body of scientific
      evidence concerning the similarities between human beings and other animals. The 
      probability is very high that they are like us in many important ways, including 
      in having a capacity to suffer. Because animals may suffer during research, their
      use must be justified. An appropriate justification will require that researchers
      can demonstrate that the expected benefits of the research, in terms of pure
      knowledge and medical applications, outweigh the suffering imposed. However,
      while the infliction of suffering on animal models must meet stringent
      conditions, research which involves the (painless) death of animals is often
      easier to justify, since few animals other than human beings possess the
      psychological capacities required to care about their future.
CI  - (c) 2012 The Author. International Journal of Stroke (c) 2012 World Stroke
      Organization.
FAU - Levy, Neil
AU  - Levy N
AD  - Florey Neuroscience Institutes, Carlton South, Vic., Australia.
      neil.nl.levy@gmail.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Int J Stroke
JT  - International journal of stroke : official journal of the International Stroke
      Society
JID - 101274068
SB  - IM
MH  - Animal Experimentation/*ethics
MH  - Animal Welfare
MH  - Animals
MH  - Disease Models, Animal
MH  - Ethics, Research
MH  - *Models, Animal
MH  - Morals
MH  - Stress, Psychological/psychology
EDAT- 2012/06/21 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/06/21 06:00
PHST- 2012/06/21 06:00 [entrez]
PHST- 2012/06/21 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
AID - 10.1111/j.1747-4949.2012.00772.x [doi]
PST - ppublish
SO  - Int J Stroke. 2012 Jul;7(5):440-2. doi: 10.1111/j.1747-4949.2012.00772.x.


PMID- 22712741
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20211021
IS  - 1747-4949 (Electronic)
IS  - 1747-4930 (Linking)
VI  - 7
IP  - 5
DP  - 2012 Jul
TI  - Etiology of stroke and choice of models.
PG  - 398-406
LID - 10.1111/j.1747-4949.2012.00838.x [doi]
AB  - Animal models of stroke contribute to the development of better stroke prevention
      and treatment through studies investigating the pathophysiology of different
      stroke subtypes and by testing promising treatments before trials in humans.
      There are two broad types of animal models: those in which stroke is induced
      through artificial means, modeling the consequences of a vascular insult but not 
      the vascular pathology itself; and those in which strokes occur spontaneously.
      Most animal models of stroke are in rodents due to cost, ethical considerations, 
      availability of standardized neurobehavioral assessments, and ease of
      physiological monitoring. While there are similarities in cerebrovascular anatomy
      and pathophysiology between rodents and humans, there are also important
      differences, including brain size, length and structure of perforating arteries, 
      and gray to white matter ratio, which is substantially lower in humans. The wide 
      range of rodent models of stroke includes models of global and focal ischemia,
      and of intracerebral and sub-arachnoid hemorrhage. The most widely studied model 
      of spontaneous stroke is the spontaneously hypertensive stroke-prone rat, in
      which the predominant lesions are small subcortical infarcts resulting from a
      vascular pathology similar to human cerebral small vessel disease. Important
      limitations of animal models of stroke - they generally model only certain
      aspects of the disease and do not reflect the heterogeneity in severity,
      pathology and comorbidities of human stroke - and key methodological issues
      (especially the need for adequate sample size, randomization, and blinding in
      treatment trials) must be carefully considered for the successful translation of 
      pathophysiological concepts and therapeutics from bench to bedside.
CI  - (c) 2012 The Authors. International Journal of Stroke (c) 2012 World Stroke
      Organization.
FAU - Krafft, Paul R
AU  - Krafft PR
AD  - Department of Physiology, School of Medicine, Loma Linda University, Loma Linda, 
      CA, USA.
FAU - Bailey, Emma L
AU  - Bailey EL
FAU - Lekic, Tim
AU  - Lekic T
FAU - Rolland, William B
AU  - Rolland WB
FAU - Altay, Orhan
AU  - Altay O
FAU - Tang, Jiping
AU  - Tang J
FAU - Wardlaw, Joanna M
AU  - Wardlaw JM
FAU - Zhang, John H
AU  - Zhang JH
FAU - Sudlow, Cathie L M
AU  - Sudlow CL
LA  - eng
GR  - CZB/4/517/CSO_/Chief Scientist Office/United Kingdom
GR  - R01 NS078755/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Int J Stroke
JT  - International journal of stroke : official journal of the International Stroke
      Society
JID - 101274068
SB  - IM
MH  - Animals
MH  - Animals, Inbred Strains
MH  - Brain Ischemia/etiology
MH  - Choice Behavior
MH  - *Disease Models, Animal
MH  - Humans
MH  - Infarction, Middle Cerebral Artery/etiology
MH  - Mice
MH  - Rats
MH  - Research Design
MH  - Stroke/*etiology/prevention & control
MH  - Subarachnoid Hemorrhage/etiology
PMC - PMC6986354
MID - NIHMS1058953
EDAT- 2012/06/21 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/06/21 06:00
PHST- 2012/06/21 06:00 [entrez]
PHST- 2012/06/21 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
AID - 10.1111/j.1747-4949.2012.00838.x [doi]
PST - ppublish
SO  - Int J Stroke. 2012 Jul;7(5):398-406. doi: 10.1111/j.1747-4949.2012.00838.x.


PMID- 22711449
OWN - NLM
STAT- MEDLINE
DCOM- 20131112
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 18
IP  - 3
DP  - 2012 Sep
TI  - Science, human nature, and a new paradigm for ethics education.
PG  - 543-9
LID - 10.1007/s11948-012-9373-8 [doi]
AB  - For centuries, religion and philosophy have been the primary basis for efforts to
      guide humans to be more ethical. However, training in ethics and religion and
      imparting positive values and morality tests such as those emanating from the
      categorical imperative and the Golden Rule have not been enough to protect
      humankind from its bad behaviors. To improve ethics education educators must
      better understand aspects of human nature such as those that lead to
      "self-deception" and "personal bias." Through rationalizations, faulty reasoning 
      and hidden bias, individuals trick themselves into believing there is little
      wrong with their own unethical behavior. The application of science to human
      nature offers the possibility of improving ethics education through better
      self-knowledge. The author recommends a new paradigm for ethics education in
      contemporary modern society. This includes the creation of a new field called
      "applied evolutionary neuro-ethics" which integrates science and social sciences 
      to improve ethics education. The paradigm can merge traditional thinking about
      ethics from religious and philosophical perspectives with new ideas from applied 
      evolutionary neuro-ethics.
FAU - Lampe, Marc
AU  - Lampe M
AD  - School of Business Administration, University of San Diego, 5998 Alcala Park, San
      Diego, CA 92110-2492, USA. mlampe@sandiego.edu
LA  - eng
PT  - Journal Article
DEP - 20120619
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
CIN - Sci Eng Ethics. 2012 Sep;18(3):551-5. PMID: 22660988
MH  - Defense Mechanisms
MH  - *Human Characteristics
MH  - Humans
MH  - Mental Processes
MH  - *Morals
MH  - Neurosciences/*ethics
MH  - Philosophy
MH  - Religion
MH  - Science/*ethics
MH  - *Social Behavior
MH  - Social Sciences
MH  - Social Values
MH  - Teaching/*ethics
EDAT- 2012/06/20 06:00
MHDA- 2013/11/13 06:00
CRDT- 2012/06/20 06:00
PHST- 2008/04/01 00:00 [received]
PHST- 2012/05/24 00:00 [accepted]
PHST- 2012/06/20 06:00 [entrez]
PHST- 2012/06/20 06:00 [pubmed]
PHST- 2013/11/13 06:00 [medline]
AID - 10.1007/s11948-012-9373-8 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2012 Sep;18(3):543-9. doi: 10.1007/s11948-012-9373-8. Epub 2012
      Jun 19.


PMID- 22710852
OWN - NLM
STAT- MEDLINE
DCOM- 20121025
LR  - 20140731
IS  - 1419-8711 (Print)
IS  - 1419-8711 (Linking)
VI  - 14
IP  - 2
DP  - 2012 Jun
TI  - [The European Psychiatric Association (EPA) guidance on suicide treatment and
      prevention].
PG  - 113-36
AB  - UNLABELLED: Suicide is a major public health problem in the WHO European Region
      accounting for over 150,000 deaths per year. Suicidal crisis: Acute intervention 
      should start immediately in order to keep the patient alive. DIAGNOSIS: An
      underlying psychiatric disorder is present in up to 90% of people who completed
      suicide. Comorbidity with depression, anxiety, substance abuse and personality
      disorders is high. In order to achieve successful prevention of suicidality,
      adequate diagnostic procedures and appropriate treatment for the underlying
      disorder are essential. TREATMENT: Existing evidence supports the efficacy of
      pharmacological treatment and cognitive behavioural therapy (CBT) in preventing
      suicidal behaviour. Some other psychological treatments are promising, but the
      supporting evidence is currently insufficient. Studies show that antidepressant
      treatment decreases the risk for suicidality among depressed patients. However,
      the risk of suicidal behaviour in depressed patients treated with antidepressants
      exists during the first 10-14 days of treatment, which requires careful
      monitoring. Short-term supplementary medication with anxiolytics and hypnotics in
      the case of anxiety and insomnia is recommended. TREATMENT with antidepressants
      of children and adolescents should only be given under supervision of a
      specialist. Long-term treatment with lithium has been shown to be effective in
      preventing both suicide and attempted suicide in patients with unipolar and
      bipolar depression. TREATMENT with clozapine is effective in reducing suicidal
      behaviour in patients with schizophrenia. Other atypical antipsychotics are
      promising but more evidence is required. TREATMENT team: Multidisciplinary
      treatment teams including psychiatrist and other professionals such as
      psychologist, social worker, and occupational therapist are always preferable, as
      integration of pharmacological, psychological and social rehabilitation is
      recommended especially for patients with chronic suicidality. Family: The
      suicidal person independently of age should always be motivated to involve family
      in the treatment. Social support: Psychosocial treatment and support is
      recommended, as the majority of suicidal patients have problems with
      relationships, work, school and lack functioning social networks. SAFETY: A
      secure home, public and hospital environment, without access to suicidal means is
      a necessary strategy in suicide prevention. Each treatment option, prescription
      of medication and discharge of the patient from hospital should be carefully
      evaluated against the involved risks. Training of personnel: Training of general 
      practitioners (GPs) is effective in the prevention of suicide. It improves
      treatment of depression and anxiety, quality of the provided care and attitudes
      towards suicide. Continuous training including discussions about ethical and
      legal issues is necessary for psychiatrists and other mental health
      professionals.
FAU - Wasserman, Danuta
AU  - Wasserman D
AD  - The National Centre for Suicide Research and Prevention of Mental Ill-Health,
      Karolinska Institutet, Stockholm, Sweden.
FAU - Rihmer, Zoltan
AU  - Rihmer Z
FAU - Rujescu, Dan
AU  - Rujescu D
FAU - Sarchiapone, Marco
AU  - Sarchiapone M
FAU - Sokolowski, Marcus
AU  - Sokolowski M
FAU - Titelman, David
AU  - Titelman D
FAU - Zalsman, Gil
AU  - Zalsman G
FAU - Zemishlany, Zvi
AU  - Zemishlany Z
FAU - Carli, Vladimir
AU  - Carli V
LA  - hun
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Az Europai Pszichiatriai Szovetseg (European Psychiatric Association, EPA)
      umutatoja az ongyilkossag kezelesere es megelozesere.
PL  - Hungary
TA  - Neuropsychopharmacol Hung
JT  - Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet
      lapja = official journal of the Hungarian Association of Psychopharmacology
JID - 100961631
SB  - IM
MH  - Adolescent
MH  - Adolescent Development
MH  - Europe
MH  - Family Therapy
MH  - Humans
MH  - Mental Disorders/complications/diagnosis/therapy
MH  - Patient Safety
MH  - Practice Guidelines as Topic
MH  - Primary Prevention/*methods
MH  - Psychiatry
MH  - Risk Assessment
MH  - Risk Factors
MH  - Social Support
MH  - Societies, Medical
MH  - *Suicidal Ideation
MH  - Suicide, Attempted/*prevention & control/*psychology
EDAT- 2012/06/20 06:00
MHDA- 2012/10/26 06:00
CRDT- 2012/06/20 06:00
PHST- 2012/06/20 06:00 [entrez]
PHST- 2012/06/20 06:00 [pubmed]
PHST- 2012/10/26 06:00 [medline]
PST - ppublish
SO  - Neuropsychopharmacol Hung. 2012 Jun;14(2):113-36.


PMID- 22710757
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20220129
IS  - 1474-4465 (Electronic)
IS  - 1474-4422 (Linking)
VI  - 11
IP  - 7
DP  - 2012 Jul
TI  - Sham neurosurgical procedures in clinical trials for neurodegenerative diseases: 
      scientific and ethical considerations.
PG  - 643-50
LID - 10.1016/S1474-4422(12)70064-9 [doi]
AB  - There have been several recent scientific advances in gene-based and cell-based
      therapies that might translate into novel therapeutic approaches for
      neurodegenerative disorders. Such therapies might need to be directly delivered
      into the CNS, and complex scientific and ethical assessment will be needed to
      determine whether a sham neurosurgical arm should be included in clinical trials 
      assessing these agents. We have developed a framework of points for investigators
      to consider when designing trials that involve direct delivery of a therapeutic
      agent to the CNS. The inclusion of a sham neurosurgical arm will be guided in
      part by the objectives of the clinical study (preliminary safety, optimisation,
      and feasibility vs preliminary efficacy vs confirmatory efficacy) and the need to
      minimise bias and confounds. Throughout the clinical development process, the
      perspectives of researchers, ethicists, and patients must be considered, and
      risks should be minimised whenever possible in a manner that is consistent with
      good trial design.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Galpern, Wendy R
AU  - Galpern WR
AD  - Office of Clinical Research, National Institute of Neurological Disorders and
      Stroke, National Institutes of Health, 6001 Executive Blvd, #2225, Bethesda, MD
      20892, USA. galpernw@ninds.nih.gov
FAU - Corrigan-Curay, Jacqueline
AU  - Corrigan-Curay J
FAU - Lang, Anthony E
AU  - Lang AE
FAU - Kahn, Jeffrey
AU  - Kahn J
FAU - Tagle, Danilo
AU  - Tagle D
FAU - Barker, Roger A
AU  - Barker RA
FAU - Freeman, Thomas B
AU  - Freeman TB
FAU - Goetz, Christopher G
AU  - Goetz CG
FAU - Kieburtz, Karl
AU  - Kieburtz K
FAU - Kim, Scott Y H
AU  - Kim SY
FAU - Piantadosi, Steven
AU  - Piantadosi S
FAU - Comstock Rick, Amy
AU  - Comstock Rick A
FAU - Federoff, Howard J
AU  - Federoff HJ
LA  - eng
GR  - 079249/WT_/Wellcome Trust/United Kingdom
GR  - G0800784/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PL  - England
TA  - Lancet Neurol
JT  - The Lancet. Neurology
JID - 101139309
RN  - 0 (Placebos)
SB  - IM
CIN - Lancet Neurol. 2012 Dec;11(12):1022. PMID: 23153402
MH  - Clinical Trials as Topic/*ethics
MH  - Humans
MH  - Neurodegenerative Diseases/*therapy
MH  - Neurosurgical Procedures/*ethics
MH  - Nontherapeutic Human Experimentation/*ethics
MH  - *Placebos
EDAT- 2012/06/20 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/06/20 06:00
PHST- 2012/06/20 06:00 [entrez]
PHST- 2012/06/20 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
AID - S1474-4422(12)70064-9 [pii]
AID - 10.1016/S1474-4422(12)70064-9 [doi]
PST - ppublish
SO  - Lancet Neurol. 2012 Jul;11(7):643-50. doi: 10.1016/S1474-4422(12)70064-9.


PMID- 22710526
OWN - NLM
STAT- MEDLINE
DCOM- 20130603
LR  - 20130211
IS  - 1538-3660 (Electronic)
IS  - 1521-2491 (Linking)
VI  - 14
IP  - 6
DP  - 2012 Nov
TI  - Ethical considerations in aesthetic rhinoplasty: a survey, critical analysis, and
      review.
PG  - 442-50
LID - 10.1001/archfacial.2012.132 [doi]
AB  - Although the practice of medicine is built on a foundation of ethics, science,
      and common sense, the increasing complexity of medical interventions, social
      interactions, and societal norms of behavior challenges the ethical practice of
      aesthetic surgeons. We report a survey of the opinions, practices, and attitudes 
      of experienced and novice facial plastic surgeons. The survey consisted of 15
      clinical vignettes addressing ethical quandaries in aesthetic rhinoplasty. The
      vignettes are based on the experience and observations of the senior author
      (P.A.A.) over nearly 30 years of practice and teaching. Fellowship directors and 
      facial plastic surgery fellows of the American Academy of Facial Plastic and
      Reconstructive Surgery were surveyed anonymously. Five of the 15 vignettes
      demonstrated significant differences between the responses of the fellowship
      directors and the fellows. No single vignette had a unanimous consensus in either
      group. Aesthetic rhinoplasty surgeons encounter ethical issues that should be
      reflected on by both experienced and inexperienced facial plastic surgeons,
      preferably before being faced with them in practice. We present a practical
      approach to ethical issues in clinical practice. Our survey can also be used as a
      stimulus for further discussion and teaching.
FAU - Karimi, Kian
AU  - Karimi K
AD  - Pacific Eye & Ear Specialists, 11645 Wilshire Blvd, Los Angeles,CA 90025, USA.
      kiankarimi@gmail.com
FAU - McKneally, Martin F
AU  - McKneally MF
FAU - Adamson, Peter A
AU  - Adamson PA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Arch Facial Plast Surg
JT  - Archives of facial plastic surgery
JID - 100883500
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Consensus
MH  - Esthetics
MH  - *Faculty, Medical
MH  - Health Care Surveys
MH  - Humans
MH  - Physicians/*ethics/psychology
MH  - Rhinoplasty/*ethics
MH  - *Students, Medical/psychology
MH  - United States
EDAT- 2012/06/20 06:00
MHDA- 2013/06/05 06:00
CRDT- 2012/06/20 06:00
PHST- 2012/06/20 06:00 [entrez]
PHST- 2012/06/20 06:00 [pubmed]
PHST- 2013/06/05 06:00 [medline]
AID - 1182546 [pii]
AID - 10.1001/archfacial.2012.132 [doi]
PST - ppublish
SO  - Arch Facial Plast Surg. 2012 Nov;14(6):442-50. doi: 10.1001/archfacial.2012.132.


PMID- 22709665
OWN - NLM
STAT- MEDLINE
DCOM- 20120820
LR  - 20160523
IS  - 2212-2672 (Print)
IS  - 2212-2672 (Linking)
VI  - 112
IP  - 3
DP  - 2012 Mar
TI  - Elements of ethical billing for nutrition professionals.
PG  - 432-5
LID - 10.1016/j.jand.2012.01.007 [doi]
FAU - Hodorowicz, Mary Ann
AU  - Hodorowicz MA
AD  - LLC, Palos Heights, IL, USA.
FAU - White, Jane V
AU  - White JV
LA  - eng
PT  - Journal Article
DEP - 20120301
PL  - United States
TA  - J Acad Nutr Diet
JT  - Journal of the Academy of Nutrition and Dietetics
JID - 101573920
SB  - IM
MH  - Dietetics/*ethics/legislation & jurisprudence
MH  - *Ethics, Professional
MH  - Fees and Charges/*ethics/legislation & jurisprudence
MH  - Humans
MH  - United States
EDAT- 2012/06/20 06:00
MHDA- 2012/08/21 06:00
CRDT- 2012/06/20 06:00
PHST- 2012/06/20 06:00 [entrez]
PHST- 2012/06/20 06:00 [pubmed]
PHST- 2012/08/21 06:00 [medline]
AID - S2212-2672(12)00048-2 [pii]
AID - 10.1016/j.jand.2012.01.007 [doi]
PST - ppublish
SO  - J Acad Nutr Diet. 2012 Mar;112(3):432-5. doi: 10.1016/j.jand.2012.01.007. Epub
      2012 Mar 1.


PMID- 22709520
OWN - NLM
STAT- MEDLINE
DCOM- 20121009
LR  - 20160520
IS  - 1879-6265 (Electronic)
IS  - 1879-6257 (Linking)
VI  - 2
IP  - 3
DP  - 2012 Jun
TI  - Licensure of vaccines using the Animal Rule.
PG  - 353-6
LID - 10.1016/j.coviro.2012.01.004 [doi]
AB  - A number of new vaccines are being developed against microbial pathogens that
      might be used as bioweapons. For some of these vaccines, because of the lack of
      endemic disease and the lethal nature of the disease, human efficacy studies
      would not be ethical or feasible to conduct. In such cases, a regulation, known
      as the 'Animal Rule', can be used which allows the United States Food and Drug
      Administration to consider appropriate animal studies as evidence of
      effectiveness of a vaccine. Using this rule, pathways to licensure are being
      developed for new vaccines against bioweapons based on well-designed animal
      studies. The results of those animal protection studies together with the best
      scientific information available concerning immune mechanisms of protection allow
      protection in the animals to be bridged to effectiveness in humans, usually
      through the use of an appropriate immune marker.
CI  - Published by Elsevier B.V.
FAU - Burns, Drusilla L
AU  - Burns DL
AD  - Center for Biologics Evaluation and Research, Food and Drug Administration,
      Building 29, Room 130, HFM-434, 8800 Rockville Pike, Bethesda, MD 20892, USA.
      drusilla.burns@fda.hhs.gov
LA  - eng
PT  - Journal Article
DEP - 20120130
PL  - Netherlands
TA  - Curr Opin Virol
JT  - Current opinion in virology
JID - 101560941
RN  - 0 (Vaccines)
SB  - IM
MH  - Animals
MH  - *Disease Models, Animal
MH  - Drug Approval/*legislation & jurisprudence/*methods
MH  - Humans
MH  - United States
MH  - Vaccines/administration & dosage/*adverse effects/*immunology
EDAT- 2012/06/20 06:00
MHDA- 2012/10/10 06:00
CRDT- 2012/06/20 06:00
PHST- 2011/12/16 00:00 [received]
PHST- 2012/01/04 00:00 [accepted]
PHST- 2012/06/20 06:00 [entrez]
PHST- 2012/06/20 06:00 [pubmed]
PHST- 2012/10/10 06:00 [medline]
AID - S1879-6257(12)00006-5 [pii]
AID - 10.1016/j.coviro.2012.01.004 [doi]
PST - ppublish
SO  - Curr Opin Virol. 2012 Jun;2(3):353-6. doi: 10.1016/j.coviro.2012.01.004. Epub
      2012 Jan 30.


PMID- 22709390
OWN - NLM
STAT- MEDLINE
DCOM- 20120904
LR  - 20220408
IS  - 1468-0009 (Electronic)
IS  - 0887-378X (Linking)
VI  - 90
IP  - 2
DP  - 2012 Jun
TI  - Uncovering the benefits of participatory research: implications of a realist
      review for health research and practice.
PG  - 311-46
LID - 10.1111/j.1468-0009.2012.00665.x [doi]
AB  - CONTEXT: Participatory research (PR) is the co-construction of research through
      partnerships between researchers and people affected by and/or responsible for
      action on the issues under study. Evaluating the benefits of PR is challenging
      for a number of reasons: the research topics, methods, and study designs are
      heterogeneous; the extent of collaborative involvement may vary over the duration
      of a project and from one project to the next; and partnership activities may
      generate a complex array of both short- and long-term outcomes. METHODS: Our
      review team consisted of a collaboration among researchers and decision makers in
      public health, research funding, ethics review, and community-engaged
      scholarship. We identified, selected, and appraised a large-variety sample of
      primary studies describing PR partnerships, and in each stage, two team members
      independently reviewed and coded the literature. We used key realist review
      concepts (middle-range theory, demi-regularity, and context-mechanism-outcome
      configurations [CMO]) to analyze and synthesize the data, using the PR
      partnership as the main unit of analysis. FINDINGS: From 7,167 abstracts and 591 
      full-text papers, we distilled for synthesis a final sample of twenty-three PR
      partnerships described in 276 publications. The link between process and outcome 
      in these partnerships was best explained using the middle-range theory of
      partnership synergy, which demonstrates how PR can (1) ensure culturally and
      logistically appropriate research, (2) enhance recruitment capacity, (3) generate
      professional capacity and competence in stakeholder groups, (4) result in
      productive conflicts followed by useful negotiation, (5) increase the quality of 
      outputs and outcomes over time, (6) increase the sustainability of project goals 
      beyond funded time frames and during gaps in external funding, and (7) create
      system changes and new unanticipated projects and activities. Negative examples
      illustrated why these outcomes were not a guaranteed product of PR partnerships
      but were contingent on key aspects of context. CONCLUSIONS: We used a realist
      approach to embrace the heterogeneity and complexity of the PR literature. This
      theory-driven synthesis identified mechanisms by which PR may add value to the
      research process. Using the middle-range theory of partnership synergy, our
      review confirmed findings from previous PR reviews, documented and explained some
      negative outcomes, and generated new insights into the benefits of PR regarding
      conflicts and negotiation between stakeholders, program sustainability and
      advancement, unanticipated project activity, and the generation of systemic
      change.
CI  - (c) 2012 Milbank Memorial Fund.
FAU - Jagosh, Justin
AU  - Jagosh J
AD  - Participatory Research at McGill, McGill University. justin.jagosh@mail.mcgill.ca
FAU - Macaulay, Ann C
AU  - Macaulay AC
FAU - Pluye, Pierre
AU  - Pluye P
FAU - Salsberg, Jon
AU  - Salsberg J
FAU - Bush, Paula L
AU  - Bush PL
FAU - Henderson, Jim
AU  - Henderson J
FAU - Sirett, Erin
AU  - Sirett E
FAU - Wong, Geoff
AU  - Wong G
FAU - Cargo, Margaret
AU  - Cargo M
FAU - Herbert, Carol P
AU  - Herbert CP
FAU - Seifer, Sarena D
AU  - Seifer SD
FAU - Green, Lawrence W
AU  - Green LW
FAU - Greenhalgh, Trisha
AU  - Greenhalgh T
LA  - eng
GR  - 10/1008/07/DH_/Department of Health/United Kingdom
GR  - HS&DR/10/1008/07/DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Milbank Q
JT  - The Milbank quarterly
JID - 8607003
SB  - IM
MH  - Capacity Building
MH  - *Community-Based Participatory Research
MH  - Cooperative Behavior
MH  - Health Services Research
MH  - Humans
MH  - Personnel Selection
MH  - *Program Evaluation
PMC - PMC3460206
EDAT- 2012/06/20 06:00
MHDA- 2012/09/05 06:00
CRDT- 2012/06/20 06:00
PHST- 2012/06/20 06:00 [entrez]
PHST- 2012/06/20 06:00 [pubmed]
PHST- 2012/09/05 06:00 [medline]
AID - 10.1111/j.1468-0009.2012.00665.x [doi]
PST - ppublish
SO  - Milbank Q. 2012 Jun;90(2):311-46. doi: 10.1111/j.1468-0009.2012.00665.x.


PMID- 22709143
OWN - NLM
STAT- MEDLINE
DCOM- 20121015
LR  - 20211021
IS  - 1471-2431 (Electronic)
IS  - 1471-2431 (Linking)
VI  - 12
DP  - 2012 Jun 18
TI  - Pediatrician's perspectives on discharge against medical advice (DAMA) among
      pediatric patients: a qualitative study.
PG  - 75
LID - 10.1186/1471-2431-12-75 [doi]
AB  - BACKGROUND: The phenomenon of discharge against medical advice (DAMA) among
      pediatric patients places pediatricians in a dilemma between respect for the
      parent's decision and the desire to provide complete care for the vulnerable
      child-patient. Little has been written about factors that affect a pediatrician's
      decision to allow a parent to discharge his child against medical advice. This
      qualitative study aims to answer the question of how pediatric residents in a
      tertiary government hospital perceive and decide on a DAMA request from a parent 
      or primary caregiver. METHODS: Using a focus group discussion approach, 11
      pediatric residents from a government-run tertiary hospital were recruited for
      the study. The session was digitally recorded and dominant themes were coded and 
      identified. RESULTS: There were three prominent themes that arose in the
      discussion: variability of definitions of DAMA, factors considered before
      "allowing" the patient to be DAMA, and the implications of a DAMA request on
      their performance as pediatricians. Definitions vary from one resident to another
      based on the main reason for DAMA (terminal, cultural, or financial). A conflict 
      was noted in the definition of Home per Request (HPR) versus DAMA. Factors that
      influence a pediatrician to sign out a case as DAMA include: their ability to do 
      something about the reason given for the DAMA request, the condition of the
      patient when the DAMA request was given, their impression of the kind of care
      that the parents provide, and their legal liabilities. Pediatric residents
      generally maintain a positive attitude towards the parents who request for DAMA
      and in the event of readmission, accept the patient into their care again.The
      occurrence of a variety of definitions and subcategories for DAMA may cause
      confusion among the pediatricians and should be clarified. The familiarity with
      cultural traditions contributes to their ability to handle situations that may
      lead to DAMA but this should always be considered in the context of the
      pediatrician's legal liabilities. The attitude of being helpful in spite of
      readmission after DAMA is an important attribute to be encouraged among new
      trainees. CONCLUSION: In most reviews about the phenomenon of DAMA, patient
      characteristics have been identified that make them prone to request for DAMA
      however; physicians also experience a complex process of decision-making in DAMA 
      situations. It is therefore vital for every training institution to include
      ethical, legal and moral aspects of learning into their training programs
      especially in dealing with cases of DAMA.
FAU - Macrohon, Bernadette C
AU  - Macrohon BC
AD  - Department of Pediatrics, Zamboanga City Medical Center, Zamboanga City,
      Philippines. bcchuamacrohon@gmail.com
LA  - eng
PT  - Journal Article
DEP - 20120618
PL  - England
TA  - BMC Pediatr
JT  - BMC pediatrics
JID - 100967804
SB  - IM
MH  - *Attitude of Health Personnel
MH  - Child
MH  - Child Welfare/ethics
MH  - Cultural Competency
MH  - *Dissent and Disputes
MH  - Female
MH  - Focus Groups
MH  - Humans
MH  - Internship and Residency
MH  - Liability, Legal
MH  - Male
MH  - *Patient Discharge
MH  - Pediatrics
MH  - Philippines
MH  - Physicians/ethics/*psychology
MH  - *Professional-Family Relations/ethics
MH  - Qualitative Research
MH  - *Treatment Refusal
PMC - PMC3407506
EDAT- 2012/06/20 06:00
MHDA- 2012/10/16 06:00
CRDT- 2012/06/20 06:00
PHST- 2011/06/10 00:00 [received]
PHST- 2012/06/18 00:00 [accepted]
PHST- 2012/06/20 06:00 [entrez]
PHST- 2012/06/20 06:00 [pubmed]
PHST- 2012/10/16 06:00 [medline]
AID - 1471-2431-12-75 [pii]
AID - 10.1186/1471-2431-12-75 [doi]
PST - epublish
SO  - BMC Pediatr. 2012 Jun 18;12:75. doi: 10.1186/1471-2431-12-75.


PMID- 22708805
OWN - NLM
STAT- MEDLINE
DCOM- 20141006
LR  - 20131114
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 13
IP  - 3
DP  - 2013 Dec
TI  - Embryo donation in Iran: an ethical review.
PG  - 119-24
LID - 10.1111/j.1471-8847.2012.00334.x [doi]
AB  - Iran is the only Muslim country that has legislation on embryo donation, adopted 
      in 2003. With an estimated 10-15% of couples in the country that are infertile,
      there are not any legal or religious barriers that prohibit an infertile couple
      from taking advantage of Assisted Reproductive Technologies (ARTs). Although all 
      forms of ARTs available in Iran have been legitimized by religious authorities,
      there is a lack of legislation in all ARTs except embryo donation. By
      highlighting ethical issues in embryo donation, the paper presents a critical
      review of the Act of Embryo Donation in Iran. The paper argues that the Act does 
      not provide enough safeguards for the future child and assurance for the safety
      of the donated embryos. It also does not restrict embryo donation to surplus
      embryos from infertile couples and is silent about the number of embryos that
      could be donated by each couple as well as the number of recipients for donated
      embryos by a couple. The Act is also silent about the issues of genetic linkage
      (nasab) and heritage which are challenging issues, especially in a conservative
      Islamic society. As a result, the future child may not inherit from their birth
      parents, as it is not required by the Act, or from the genetically related
      parents under the anonymity policy. Finally there is no standard national
      protocol or guidelines to evaluate the safety of the donated embryos. The paper
      concludes that despite its benefits, the Act lacks clarity, and it is subject to 
      misunderstanding and confusion.
CI  - (c) 2012 John Wiley & Sons Ltd.
FAU - Afshar, Leila
AU  - Afshar L
AD  - Shiraz University of Medical Sciences in IranTehran University of Medical
      Sciences, Center for Medical Ethics in Iran.
FAU - Bagheri, Alireza
AU  - Bagheri A
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120618
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
SB  - IM
MH  - Embryo Disposition/ethics/*legislation & jurisprudence
MH  - Ethical Review
MH  - Humans
MH  - Iran
MH  - *Islam
MH  - Legislation, Medical/standards
MH  - Reproductive Techniques, Assisted/ethics/*legislation & jurisprudence
OTO - NOTNLM
OT  - ARTs
OT  - Iran
OT  - Islamic bioethics
OT  - embryo donation
EDAT- 2012/06/20 06:00
MHDA- 2014/10/07 06:00
CRDT- 2012/06/20 06:00
PHST- 2012/06/20 06:00 [entrez]
PHST- 2012/06/20 06:00 [pubmed]
PHST- 2014/10/07 06:00 [medline]
AID - 10.1111/j.1471-8847.2012.00334.x [doi]
PST - ppublish
SO  - Dev World Bioeth. 2013 Dec;13(3):119-24. doi: 10.1111/j.1471-8847.2012.00334.x.
      Epub 2012 Jun 18.


PMID- 22708740
OWN - NLM
STAT- MEDLINE
DCOM- 20141006
LR  - 20131114
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 13
IP  - 3
DP  - 2013 Dec
TI  - Off-shoring clinical research: exploitation and the reciprocity constraint.
PG  - 111-8
LID - 10.1111/j.1471-8847.2012.00332.x [doi]
AB  - The last 20 years have seen a staggering growth in the practice of off-shoring
      clinical research to low-and middle-income countries (LICs and MICs), a growth
      that has been matched by the neoliberal policies adopted by host countries
      towards attracting trials to their shores. A recurring concern in this context is
      the charge of exploitation, linked to various aspects of off-shoring. In this
      paper, I examine Alan Wertheimer's approach and offer an alternative view of
      understanding exploitation in this context. I will suggest that the justification
      for the enterprise of research is largely dependent on its integration within a
      health system from which participants regularly benefit and I argue that an
      attention to a principle of reciprocity will enable us to better recognize and
      address exploitation in international research.
CI  - (c) 2012 John Wiley & Sons Ltd.
FAU - Mitra, Agomoni Ganguli
AU  - Mitra AG
AD  - University of Zurich.
LA  - eng
PT  - Journal Article
DEP - 20120618
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Clinical Trials as Topic/*ethics/trends
MH  - Community-Based Participatory Research/ethics/trends
MH  - *Developing Countries/economics
MH  - Ethics, Research
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Outsourced Services/*ethics/trends
MH  - *Poverty
OTO - NOTNLM
OT  - bioethics
OT  - clinical trials
OT  - developing world
OT  - research ethics
EDAT- 2012/06/20 06:00
MHDA- 2014/10/07 06:00
CRDT- 2012/06/20 06:00
PHST- 2012/06/20 06:00 [entrez]
PHST- 2012/06/20 06:00 [pubmed]
PHST- 2014/10/07 06:00 [medline]
AID - 10.1111/j.1471-8847.2012.00332.x [doi]
PST - ppublish
SO  - Dev World Bioeth. 2013 Dec;13(3):111-8. doi: 10.1111/j.1471-8847.2012.00332.x.
      Epub 2012 Jun 18.


PMID- 22708713
OWN - NLM
STAT- MEDLINE
DCOM- 20121003
LR  - 20211021
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 12
IP  - 2
DP  - 2012 Aug
TI  - Research ethics capacity development in Africa: exploring a model for individual 
      success.
PG  - 55-62
LID - 10.1111/j.1471-8847.2012.00331.x [doi]
AB  - The Johns Hopkins-Fogarty African Bioethics Training Program (FABTP) has offered 
      a fully-funded, one-year, non-degree training opportunity in research ethics to
      health professionals, ethics committee members, scholars, journalists and
      scientists from countries across sub-Saharan Africa. In the first 9 years of
      operation, 28 trainees from 13 African countries have trained with FABTP. Any
      capacity building investment requires periodic critical evaluation of the impact 
      that training dollars produce. In this paper we describe and evaluate FABTP and
      the efforts of its trainees. Our data show that since 2001, the 28 former FABTP
      trainees have authored or co-authored 105 new bioethics-related publications;
      were awarded 33 bioethics-related grants; played key roles on 78
      bioethics-related research studies; and participated in 198 bioethics workshops
      or conferences. Over the past nine years, trainees have collectively taught 48
      separate courses related to bioethics and have given 170 presentations on various
      topics in the field. Many former trainees have pursued and completed doctoral
      degrees in bioethics; some have become editorial board members for bioethics
      journals. Female trainees were, on average, less experienced at matriculation and
      produced fewer post-training outputs than their male counterparts. More
      comprehensive studies are needed to determine the relationships between age, sex,
      previous experience and training program outputs.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Ali, Joseph
AU  - Ali J
AD  - Johns Hopkins Berman Institute of Bioethics.
FAU - Hyder, Adnan A
AU  - Hyder AA
FAU - Kass, Nancy E
AU  - Kass NE
LA  - eng
GR  - R25 TW001604/TW/FIC NIH HHS/United States
GR  - 5R25TW001604/TW/FIC NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20120618
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
SB  - IM
MH  - Adult
MH  - Africa South of the Sahara
MH  - Bioethics/education
MH  - Education/economics
MH  - Educational Status
MH  - Ethics, Research/*education
MH  - Female
MH  - Humans
MH  - International Cooperation
MH  - Male
MH  - Middle Aged
MH  - Publications/*statistics & numerical data
MH  - Research Support as Topic/*statistics & numerical data
MH  - Sex Factors
MH  - Teaching/*statistics & numerical data
MH  - United States
PMC - PMC3393778
MID - NIHMS372063
EDAT- 2012/06/20 06:00
MHDA- 2012/10/04 06:00
CRDT- 2012/06/20 06:00
PHST- 2012/06/20 06:00 [entrez]
PHST- 2012/06/20 06:00 [pubmed]
PHST- 2012/10/04 06:00 [medline]
AID - 10.1111/j.1471-8847.2012.00331.x [doi]
PST - ppublish
SO  - Dev World Bioeth. 2012 Aug;12(2):55-62. doi: 10.1111/j.1471-8847.2012.00331.x.
      Epub 2012 Jun 18.


PMID- 22708642
OWN - NLM
STAT- MEDLINE
DCOM- 20130121
LR  - 20121105
IS  - 1471-8847 (Electronic)
IS  - 1471-8731 (Linking)
VI  - 12
IP  - 3
DP  - 2012 Dec
TI  - Coercion, autonomy, and the preferential option for the poor in the ethics of
      organ transplantation.
PG  - 135-47
LID - 10.1111/j.1471-8847.2012.00327.x [doi]
AB  - The debate concerning whether to legalize and regulate the global market in human
      organs is hindered by a lack of adequate bioethical language. The author argues
      that the preferential option for the poor, a theological category, can provide
      the grounding for an inductive moral epistemology adequate for reforming the use 
      of culturally Western bioethical language. He proposes that the traditional,
      Western concept of bioethical coercion ought to be modified and expanded because 
      the conditions of the market system, as viewed from the perspective of organ
      vendors systemically deprived of access to sufficient resources, are sufficiently
      exploitative as to diminish the possibility of these vendors giving informed
      consent. Moreover, empirical studies conducted by professionals in medicine,
      sociology, psychiatry, economics, and medical anthropology continue to contribute
      support to the growing interdisciplinary consensus that functionally coercive
      structural factors exert the most significant influence upon a vendor's decision 
      to sell an organ within any market, regardless of legality or degree of
      regulation. Therefore any proposal to legalize and regulate the organ market
      remains patently unethical because doing so would likely function to constrain
      further the agency of poor potential vendors.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Jaycox, Michael P
AU  - Jaycox MP
AD  - Boston College, Chestnut Hill, Massachusetts 02467, United States. jaycoxm@bc.edu
LA  - eng
PT  - Journal Article
DEP - 20120618
PL  - England
TA  - Dev World Bioeth
JT  - Developing world bioethics
JID - 101120122
SB  - IM
MH  - *Coercion
MH  - *Commerce/ethics/trends
MH  - Consensus
MH  - *Developing Countries
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Medical Tourism
MH  - Organ Transplantation/*ethics
MH  - *Personal Autonomy
MH  - *Poverty
MH  - Tissue and Organ Procurement/*ethics/standards/trends
MH  - United States
EDAT- 2012/06/20 06:00
MHDA- 2013/01/23 06:00
CRDT- 2012/06/20 06:00
PHST- 2012/06/20 06:00 [entrez]
PHST- 2012/06/20 06:00 [pubmed]
PHST- 2013/01/23 06:00 [medline]
AID - 10.1111/j.1471-8847.2012.00327.x [doi]
PST - ppublish
SO  - Dev World Bioeth. 2012 Dec;12(3):135-47. doi: 10.1111/j.1471-8847.2012.00327.x.
      Epub 2012 Jun 18.


PMID- 22708612
OWN - NLM
STAT- MEDLINE
DCOM- 20130517
LR  - 20220331
IS  - 1471-2377 (Electronic)
IS  - 1471-2377 (Linking)
VI  - 12
DP  - 2012 Jun 18
TI  - Observation and execution of upper-limb movements as a tool for rehabilitation of
      motor deficits in paretic stroke patients: protocol of a randomized clinical
      trial.
PG  - 42
LID - 10.1186/1471-2377-12-42 [doi]
AB  - BACKGROUND: Evidence exist that motor observation activates the same cortical
      motor areas that are involved in the performance of the observed actions. The so 
      called "mirror neuron system" has been proposed to be responsible for this
      phenomenon. We employ this neural system and its capability to re-enact stored
      motor representations as a tool for rehabilitating motor control. In our new
      neurorehabilitative schema (videotherapy) we combine observation of daily actions
      with concomitant physical training of the observed actions focusing on the upper 
      limbs. Following a pilot study in chronic patients in an ambulatory setting, we
      currently designed a new multicenter clinical study dedicated to patients in the 
      sub-acute state after stroke using a home-based self-induced training. Within our
      protocol we assess 1) the capability of action observation to elicit
      rehabilitational effects in the motor system, and 2) the capacity of this schema 
      to be performed by patients without assistance from a physiotherapist. The
      results of this study would be of high health and economical relevance.
      METHODS/DESIGN: A controlled, randomized, multicenter, paralleled, 6 month
      follow-up study will be conducted on three groups of patients: one group will be 
      given the experimental treatment whereas the other two will participate in
      control treatments. All patients will undergo their usual rehabilitative
      treatment beside participation in the study. The experimental condition consists 
      in the observation and immediate imitation of common daily hand and arm actions. 
      The two parallel control groups are a placebo group and a group receiving usual
      rehabilitation without any trial-related treatment. Trial randomization is
      provided via external data management. The primary efficacy endpoint is the
      improvement of the experimental group in a standardized motor function test (Wolf
      Motor Function Test) relative to control groups. Further assessments refer to
      subjective and qualitative rehabilitational scores. This study has been reviewed 
      and approved by the ethics committee of Aachen University. DISCUSSION: This
      therapy provides an extension of therapeutic procedures for recovery after stroke
      and emphasizes the importance of action perception in neurorehabilitation The
      results of the study could become implemented into the wide physiotherapeutic
      practice, for example as an ad on and individualized therapy.
FAU - Ertelt, Denis
AU  - Ertelt D
AD  - Center for Clinical Trials, University of Lubeck, Maria-Goeppert-Strasse 1,23562,
      Lubeck, Germany.
FAU - Hemmelmann, Claudia
AU  - Hemmelmann C
FAU - Dettmers, Christian
AU  - Dettmers C
FAU - Ziegler, Andreas
AU  - Ziegler A
FAU - Binkofski, Ferdinand
AU  - Binkofski F
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20120618
PL  - England
TA  - BMC Neurol
JT  - BMC neurology
JID - 100968555
SB  - IM
MH  - Adult
MH  - Aged
MH  - Arm/physiopathology
MH  - Biofeedback, Psychology/*methods
MH  - Female
MH  - Germany
MH  - Home Care Services
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Movement
MH  - Paresis/*diagnosis/etiology/*rehabilitation
MH  - Self Care/*methods
MH  - Stroke/complications/*diagnosis
MH  - *Stroke Rehabilitation
MH  - Treatment Outcome
MH  - Video Recording/methods
PMC - PMC3495666
EDAT- 2012/06/20 06:00
MHDA- 2013/05/18 06:00
CRDT- 2012/06/20 06:00
PHST- 2011/11/28 00:00 [received]
PHST- 2012/06/18 00:00 [accepted]
PHST- 2012/06/20 06:00 [entrez]
PHST- 2012/06/20 06:00 [pubmed]
PHST- 2013/05/18 06:00 [medline]
AID - 1471-2377-12-42 [pii]
AID - 10.1186/1471-2377-12-42 [doi]
PST - epublish
SO  - BMC Neurol. 2012 Jun 18;12:42. doi: 10.1186/1471-2377-12-42.


PMID- 22707980
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1747-4108 (Print)
IS  - 1747-4108 (Linking)
VI  - 7
IP  - 3
DP  - 2012 May 1
TI  - Animal models of female pelvic organ prolapse: lessons learned.
PG  - 249-260
AB  - Pelvic organ prolapse is a vaginal protrusion of female pelvic organs. It has
      high prevalence worldwide and represents a great burden to the economy. The
      pathophysiology of pelvic organ prolapse is multifactorial and includes genetic
      predisposition, aberrant connective tissue, obesity, advancing age, vaginal
      delivery and other risk factors. Owing to the long course prior to patients
      becoming symptomatic and ethical questions surrounding human studies, animal
      models are necessary and useful. These models can mimic different human
      characteristics - histological, anatomical or hormonal, but none present all of
      the characteristics at the same time. Major animal models include knockout mice, 
      rats, sheep, rabbits and nonhuman primates. In this article we discuss different 
      animal models and their utility for investigating the natural progression of
      pelvic organ prolapse pathophysiology and novel treatment approaches.
FAU - Couri, Bruna M
AU  - Couri BM
AD  - Department of Biomedical Engineering, Cleveland Clinic, 9500 Euclid Avenue ND20
      Cleveland, OH 44195, USA.
FAU - Lenis, Andrew T
AU  - Lenis AT
FAU - Borazjani, Ali
AU  - Borazjani A
FAU - Paraiso, Marie Fidela R
AU  - Paraiso MF
FAU - Damaser, Margot S
AU  - Damaser MS
LA  - eng
GR  - R01 HD059859/HD/NICHD NIH HHS/United States
PT  - Journal Article
PL  - England
TA  - Expert Rev Obstet Gynecol
JT  - Expert review of obstetrics & gynecology
JID - 101278194
PMC - PMC3374602
MID - NIHMS380943
EDAT- 2012/06/19 06:00
MHDA- 2012/06/19 06:01
CRDT- 2012/06/19 06:00
PHST- 2012/06/19 06:00 [entrez]
PHST- 2012/06/19 06:00 [pubmed]
PHST- 2012/06/19 06:01 [medline]
AID - 10.1586/eog.12.24 [doi]
PST - ppublish
SO  - Expert Rev Obstet Gynecol. 2012 May 1;7(3):249-260. doi: 10.1586/eog.12.24.


PMID- 22707928
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1615-6609 (Print)
IS  - 1615-6609 (Linking)
VI  - 8
IP  - 4
DP  - 2012 Jun
TI  - The agricultural ethics of biofuels: climate ethics and mitigation arguments.
PG  - 169-189
AB  - An environmental, climate mitigation rationale for research and development (R&D)
      on liquid transportation fuels derived from plants emerged among many scientists 
      and engineers during the last decade. However, between 2006 and 2010, this
      climate ethic for pursuing biofuel became politically entangled and conceptually 
      confused with rationales for encouraging greater use of plant-based ethanol that 
      were both unconnected to climate ethics and potentially in conflict with the
      value-commitments providing a mitigation-oriented reason to promote and develop
      new and expanded sources of biofuel. I argue that the conceptual construct of
      technological trajectories provides a fecund approach to the ethical evaluation
      of R&D strategies in the case of plant-based liquid transportation fuels. The
      idea of a trajectory has a current use in the literature of science studies and
      aptly summarizes a number of themes that are critical to the evaluation of tools 
      and techniques whose future shape, design, applications and potential
      consequences are necessarily somewhat speculative. In the case of biofuels, it is
      the imagined future trajectory that provides the basis for resistance to an
      emerging technology, rather than the present-day technical capabilities and the
      unexpected consequences of biofuel development.
FAU - Thompson, Paul B
AU  - Thompson PB
AD  - Department of Philosophy, Michigan State University, East Lansing, MI 48824 USA.
LA  - eng
PT  - Journal Article
DEP - 20120328
PL  - Germany
TA  - Poiesis Prax
JT  - Poiesis & praxis : international journal of ethics of science and technology
      assessment
JID - 101083157
PMC - PMC3368114
EDAT- 2012/06/19 06:00
MHDA- 2012/06/19 06:01
CRDT- 2012/06/19 06:00
PHST- 2012/06/19 06:00 [entrez]
PHST- 2012/06/19 06:00 [pubmed]
PHST- 2012/06/19 06:01 [medline]
AID - 10.1007/s10202-012-0105-6 [doi]
AID - 105 [pii]
PST - ppublish
SO  - Poiesis Prax. 2012 Jun;8(4):169-189. doi: 10.1007/s10202-012-0105-6. Epub 2012
      Mar 28.


PMID- 22707474
OWN - NLM
STAT- MEDLINE
DCOM- 20140925
LR  - 20130515
IS  - 1472-0213 (Electronic)
IS  - 1472-0205 (Linking)
VI  - 30
IP  - 6
DP  - 2013 Jun
TI  - Out-of-hospital cardiac arrest in Cork, Ireland.
PG  - 496-500
LID - 10.1136/emermed-2011-200888 [doi]
AB  - BACKGROUND: Out-of-hospital cardiac arrest (OHCA) in Ireland accounts for
      approximately 5000 deaths annually. Little published evidence exists on survival 
      from OHCA in this country to date. We aimed to characterise and describe
      'presumed cardiac' OHCA in Cork City and County attended by the Ambulance
      Service. METHODS: Dispatch records, ambulance patient records and hospital
      records for a 1-year period were examined for patient demographics, OHCA
      characteristics, interventions and patient outcomes. RESULTS: There were 231
      'presumed cardiac' OHCAs attended over the study period; 130 (56%) were in urban 
      locations and 101 (44%) in rural. OHCAs were lay-witnessed in 20% (n=46), and 22%
      (n=50) received bystander CPR. Shockable rhythm was present in 36 cases (16%) on 
      initial assessment, and there was no difference in presence of shockable rhythm
      between urban and rural OHCAs (18% vs 13%, p=0.31). Resuscitation was attempted
      in 176 cases (77.5%), of whom 27 (15%) achieved return of spontaneous circulation
      and 13 (7.4%) survived to leave hospital. Survival when the initial rhythm was
      shockable was 16.7% (6 of 36 patients). Despite longer response times for rural
      compared with urban OHCAs (median (IQR) 16.5 (11.0-23.5) vs 9 (7-12) min,
      p<0.001), survival to leave hospital alive where resuscitation was attempted was 
      similar (7.4% vs 7.4%, p=0.99, respectively). CONCLUSION: A survival rate of
      16.7% in shockable rhythms indicates scope for improvement which would influence 
      the overall survival rate which was found to be 7.4%. Real-time feedback of
      performance and quality of the continuum of patient care through a
      clinical-quality cardiac arrest registry would monitor and incentivise such
      initiatives.
FAU - Henry, Kieran
AU  - Henry K
AD  - National Ambulance Service, HSE Southern Region, South Link Road, Cork, Ireland. 
      henrykieran@gmail.com
FAU - Murphy, Adrian
AU  - Murphy A
FAU - Willis, David
AU  - Willis D
FAU - Cusack, Stephen
AU  - Cusack S
FAU - Bury, Gerard
AU  - Bury G
FAU - O'Sullivan, Iomhar
AU  - O'Sullivan I
FAU - Deasy, Conor
AU  - Deasy C
LA  - eng
PT  - Journal Article
DEP - 20120615
PL  - England
TA  - Emerg Med J
JT  - Emergency medicine journal : EMJ
JID - 100963089
SB  - IM
MH  - Aged
MH  - Cardiopulmonary Resuscitation/methods/mortality/*statistics & numerical data
MH  - Emergency Medical Services/*statistics & numerical data
MH  - Female
MH  - Humans
MH  - Ireland
MH  - Male
MH  - Middle Aged
MH  - Out-of-Hospital Cardiac Arrest/*mortality/*therapy
MH  - Rural Population/statistics & numerical data
MH  - Survival Analysis
MH  - Treatment Outcome
MH  - Urban Population/statistics & numerical data
OTO - NOTNLM
OT  - CBRN
OT  - Cardiac arrest
OT  - OHCA
OT  - acute coronary syndrome
OT  - alcohol abuse
OT  - anaesthesia
OT  - basic ambulance care
OT  - cardiac care
OT  - clinical care
OT  - doctors in PHC
OT  - education
OT  - effectiveness
OT  - emergency ambulance systems
OT  - emergency services
OT  - epidemiology
OT  - ethics
OT  - major trauma management
OT  - outcome
OT  - paramedics
OT  - pre-hospital
OT  - registry
OT  - resuscitation
OT  - rural
OT  - training
OT  - trauma
OT  - treatment
OT  - ultrasound
OT  - urban
EDAT- 2012/06/19 06:00
MHDA- 2014/09/26 06:00
CRDT- 2012/06/19 06:00
PHST- 2012/06/19 06:00 [entrez]
PHST- 2012/06/19 06:00 [pubmed]
PHST- 2014/09/26 06:00 [medline]
AID - emermed-2011-200888 [pii]
AID - 10.1136/emermed-2011-200888 [doi]
PST - ppublish
SO  - Emerg Med J. 2013 Jun;30(6):496-500. doi: 10.1136/emermed-2011-200888. Epub 2012 
      Jun 15.


PMID- 22707329
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20211021
IS  - 0250-832X (Print)
IS  - 0250-832X (Linking)
VI  - 41
IP  - 5
DP  - 2012 Jul
TI  - The ethics of scientific publishing.
PG  - 355
LID - 10.1259/dmfr/25902691 [doi]
FAU - Schulze, Ralf
AU  - Schulze R
LA  - eng
PT  - Editorial
PL  - England
TA  - Dentomaxillofac Radiol
JT  - Dento maxillo facial radiology
JID - 7609576
MH  - Authorship
MH  - Editorial Policies
MH  - Ethics, Professional
MH  - Ethics, Research
MH  - Humans
MH  - Peer Review, Research
MH  - Plagiarism
MH  - Publishing/*ethics
MH  - Scientific Misconduct/ethics
PMC - PMC3520352
EDAT- 2012/06/19 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/06/19 06:00
PHST- 2012/06/19 06:00 [entrez]
PHST- 2012/06/19 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
AID - 41/5/355 [pii]
AID - 10.1259/dmfr/25902691 [doi]
PST - ppublish
SO  - Dentomaxillofac Radiol. 2012 Jul;41(5):355. doi: 10.1259/dmfr/25902691.


PMID- 22706707
OWN - NLM
STAT- MEDLINE
DCOM- 20130319
LR  - 20121119
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 19
IP  - 6
DP  - 2012 Nov
TI  - The impact of clinical encounters on student nurses' ethical caring.
PG  - 838-48
LID - 10.1177/0969733012447017 [doi]
AB  - The aim of this study was to get a deeper understanding of student nurses'
      experiences of personal caring ethics by reflection on caring encounters with
      patients in clinical practice, ethical caring ideals, ethical problems, and
      sources for inner strength that give courage to practice good caring. In all, 24 
      Scandinavian student nurses participated voluntarily in an interview study. The
      interviews were analyzed within a phenomenological-hermeneutical approach and
      revealed three themes. The students found themselves in two different states of
      vulnerability: one in which they were overwhelmed by their vulnerability and
      began to suffer themselves and the other where their vulnerability became a
      source of development with focus on the patient. The students' ethical caring
      ideals served as fixed reference points in their ethical development, but their
      ideals were at risk of decline. The students reflected on the barriers for
      performing ethical care and nurtured their ethical ideals by providing ethical
      care in secret. Caring in secret occurred also when student nurses did not
      experience a shared ethos.
FAU - Pedersen, Birgith
AU  - Pedersen B
AD  - Aalborg Hospital, Aarhus University Hospital, Denmark.
FAU - Sivonen, Kerstin
AU  - Sivonen K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120615
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Adult
MH  - *Empathy
MH  - Female
MH  - Humans
MH  - Male
MH  - *Moral Development
MH  - *Nurse-Patient Relations
MH  - Nursing Care/*ethics
MH  - Nursing Evaluation Research
MH  - Nursing Methodology Research
MH  - Qualitative Research
MH  - Students, Nursing/*psychology
MH  - Young Adult
EDAT- 2012/06/19 06:00
MHDA- 2013/03/21 06:00
CRDT- 2012/06/19 06:00
PHST- 2012/06/19 06:00 [entrez]
PHST- 2012/06/19 06:00 [pubmed]
PHST- 2013/03/21 06:00 [medline]
AID - 0969733012447017 [pii]
AID - 10.1177/0969733012447017 [doi]
PST - ppublish
SO  - Nurs Ethics. 2012 Nov;19(6):838-48. doi: 10.1177/0969733012447017. Epub 2012 Jun 
      15.


PMID- 22705833
OWN - NLM
STAT- MEDLINE
DCOM- 20130708
LR  - 20121224
IS  - 1873-1570 (Electronic)
IS  - 0300-9572 (Linking)
VI  - 84
IP  - 1
DP  - 2013 Jan
TI  - Medical emergencies in the imaging department of a university hospital: event and
      imaging characteristics.
PG  - 21-4
LID - 10.1016/j.resuscitation.2012.05.020 [doi]
LID - S0300-9572(12)00272-9 [pii]
AB  - We aimed to describe the characteristics of medical emergencies that occurred in 
      the medical imaging department (MID) of a university hospital in Melbourne,
      Australia. A database of 'Respond Medical Emergency Team (MET)' and 'Respond
      Blue' calls was retrospectively examined for the period June 2003 to November
      2010 in relation to events that occurred in the MID. The hospital medical imaging
      database was also examined in relation to these events and, where necessary,
      patients' notes were reviewed. Ethics approval was granted by the hospital ethics
      review board. There were 124 medical emergency calls in the MID during the study 
      period, 28% Respond Blue and 72% Respond MET. Of these 124 calls, 26% occurred
      outside of usual work hours and 12% involved cardiac arrest. The most common
      reasons for the emergency calls were seizures (14%) and altered conscious state
      (13%). Contrast anaphylaxis precipitated the emergency in 4% of cases. In 83% of 
      cases the emergency calls were for patients attending the MID for diagnostic
      imaging, the remainder being for a procedure. Of the scheduled imaging
      techniques, 45% were for computed tomography. The scheduled imaging was abandoned
      due to the emergency in 12% of cases. When performed, imaging informed patient
      management in 34% of cases in diagnostic imaging and in all cases in the context 
      of image-guided procedures. Medical emergency calls in the MID often occurred
      outside usual work hours and were attributed to a range of medical problems. The 
      emergencies occurred in relation to all imaging techniques and imaging informed
      patient management in many cases.
CI  - Crown Copyright (c) 2012. Published by Elsevier Ireland Ltd. All rights reserved.
FAU - van Tonder, F C
AU  - van Tonder FC
AD  - St. Vincent's Hospital (Melbourne), Medical Imaging Department, Melbourne, VIC,
      Australia. frans.vantonder@svhm.org.au
FAU - Sutherland, T
AU  - Sutherland T
FAU - Smith, R J
AU  - Smith RJ
FAU - Chock, J M E
AU  - Chock JM
FAU - Santamaria, J D
AU  - Santamaria JD
LA  - eng
PT  - Journal Article
DEP - 20120615
PL  - Ireland
TA  - Resuscitation
JT  - Resuscitation
JID - 0332173
SB  - IM
MH  - *Emergencies
MH  - Female
MH  - Hospitals, University
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Patient Care Team/*organization & administration
MH  - *Radiology Department, Hospital
MH  - Retrospective Studies
MH  - Victoria
EDAT- 2012/06/19 06:00
MHDA- 2013/07/09 06:00
CRDT- 2012/06/19 06:00
PHST- 2011/12/28 00:00 [received]
PHST- 2012/03/28 00:00 [revised]
PHST- 2012/05/24 00:00 [accepted]
PHST- 2012/06/19 06:00 [entrez]
PHST- 2012/06/19 06:00 [pubmed]
PHST- 2013/07/09 06:00 [medline]
AID - S0300-9572(12)00272-9 [pii]
AID - 10.1016/j.resuscitation.2012.05.020 [doi]
PST - ppublish
SO  - Resuscitation. 2013 Jan;84(1):21-4. doi: 10.1016/j.resuscitation.2012.05.020.
      Epub 2012 Jun 15.


PMID- 22704716
OWN - NLM
STAT- MEDLINE
DCOM- 20130318
LR  - 20121015
IS  - 1873-7862 (Electronic)
IS  - 0924-977X (Linking)
VI  - 22
IP  - 11
DP  - 2012 Nov
TI  - The placebo arm in clinical studies for treatment of psychiatric disorders: a
      regulatory dilemma.
PG  - 804-11
LID - 10.1016/j.euroneuro.2012.03.007 [doi]
LID - S0924-977X(12)00077-6 [pii]
AB  - BACKGROUND: The use of placebo in clinical trials, and, related to this, ethical 
      and feasibility aspects, are often debated. However, regulatory authorities must 
      ensure that only new drugs with a positive benefit/risk would be granted a
      marketing authorization. It is therefore not surprising that they often put
      forward the need for placebo control in clinical trials in an area where many
      trials fail, and assay sensitivity is not self-evident. To illustrate the
      complexity that regulatory authorities encounter when faced with the registration
      dossier of products in the main psychiatric therapeutic areas, Major Depressive
      Disorder (MDD) and schizophrenia, the trial outcome for products receiving an
      opinion in the EU during the past 15 years were reviewed. DATA SOURCE: European
      Public Assessment Reports and registration files. RESULTS: A total of 45 studies 
      qualified for analysis. For the indication MDD 38% of the studies (10/26) were
      recorded as failed, and another 15% (4/26) as negative. For schizophrenia, these 
      figures were 16% (3/19) and 11% (2/19). Further exploration of the trials in MDD 
      revealed an inconsistent pattern in terms of magnitude of placebo- and
      drug-mediated response (i.e. similar studies with consistent placebo response
      provided different treatment outcomes). CONCLUSION: From a regulatory perspective
      the dilemma of a priori exclusion of the placebo arm in clinical trials in the
      domains of depression or schizophrenia cannot be solved at this time as long as
      factors influencing trial variability are not better identified or understood.
      This counts in particular for MDD where the added drug effect is not consistent
      across trials with almost identical inclusion criteria. Unfortunately, this trend
      has not changed over the past 15 years. However, all efforts should be taken to
      optimize the clinical development of drugs in the psychiatric domain, and improve
      the intrinsic quality of the clinical trials in order to allow for a different
      viewpoint.
CI  - Copyright (c) 2012 Elsevier B.V. and ECNP. All rights reserved.
FAU - Gispen-de Wied, Christine
AU  - Gispen-de Wied C
AD  - Medicines Evaluation Board, Utrecht, The Netherlands. cc.gispen@cbg-meb.nl
FAU - Stoyanova, Violeta
AU  - Stoyanova V
FAU - Yu, Yang
AU  - Yu Y
FAU - Isaac, Maria
AU  - Isaac M
FAU - Pani, Luca
AU  - Pani L
FAU - de Andres-Trelles, Fernando
AU  - de Andres-Trelles F
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120615
PL  - Netherlands
TA  - Eur Neuropsychopharmacol
JT  - European neuropsychopharmacology : the journal of the European College of
      Neuropsychopharmacology
JID - 9111390
RN  - 0 (Antidepressive Agents)
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Drugs, Investigational)
SB  - IM
MH  - Antidepressive Agents/*therapeutic use
MH  - Antipsychotic Agents/*therapeutic use
MH  - Controlled Clinical Trials as Topic/ethics/legislation & jurisprudence/*standards
MH  - Depressive Disorder, Major/drug therapy/*psychology
MH  - Drug Resistance
MH  - Drugs, Investigational/*therapeutic use
MH  - European Union
MH  - Humans
MH  - Placebo Effect
MH  - Psychopharmacology/ethics/legislation & jurisprudence/methods
MH  - Reproducibility of Results
MH  - Schizophrenia/drug therapy
MH  - *Schizophrenic Psychology
EDAT- 2012/06/19 06:00
MHDA- 2013/03/19 06:00
CRDT- 2012/06/19 06:00
PHST- 2011/07/21 00:00 [received]
PHST- 2012/03/13 00:00 [revised]
PHST- 2012/03/18 00:00 [accepted]
PHST- 2012/06/19 06:00 [entrez]
PHST- 2012/06/19 06:00 [pubmed]
PHST- 2013/03/19 06:00 [medline]
AID - S0924-977X(12)00077-6 [pii]
AID - 10.1016/j.euroneuro.2012.03.007 [doi]
PST - ppublish
SO  - Eur Neuropsychopharmacol. 2012 Nov;22(11):804-11. doi:
      10.1016/j.euroneuro.2012.03.007. Epub 2012 Jun 15.


PMID- 22704591
OWN - NLM
STAT- MEDLINE
DCOM- 20130604
LR  - 20121012
IS  - 1399-0020 (Electronic)
IS  - 0901-5027 (Linking)
VI  - 41
IP  - 11
DP  - 2012 Nov
TI  - Osteoconductive effectiveness of bone graft derived from antler cancellous bone: 
      an experimental study in the rabbit mandible defect model.
PG  - 1330-7
LID - 10.1016/j.ijom.2012.05.014 [doi]
LID - S0901-5027(12)00216-0 [pii]
AB  - The purpose of this study was to evaluate the properties of a novel inorganic
      xenogenic bone substitute, calcinated antler cancellous bone (CACB).
      Physicochemical properties of CACB including surface morphology, phase
      composition, chemical bond structure, Ca/P ratio and porosity were characterized 
      by scanning electron microscopy, X-ray diffraction spectroscopy,
      Fourier-transform infrared spectroscopy, inductively coupled plasma-atomic
      emission spectroscopy and nitrogen adsorption analysis, and were found to closely
      resemble calcinated human cancellous bone. The bone defect repair efficacy of
      CACB was evaluated in comparison with commercially available bone substitutes
      (Bio-Oss((R))) within rabbit mandible defects. The gross observation, micro-CT
      and histology analysis data demonstrated that CACB was efficacious for bone
      regeneration, and was comparable with Bio-Oss((R)) bone substitute in inducing
      neovascularization and osteogenesis within the mandible defects. CACB can
      therefore serve as a safe, renewable, and sustainable source of bone graft
      material, but without the ethical issues pertaining to animal welfare.
CI  - Copyright (c) 2012 International Association of Oral and Maxillofacial Surgeons. 
      Published by Elsevier Ltd. All rights reserved.
FAU - Zhang, X
AU  - Zhang X
AD  - Department of Geriatric Dentistry, Peking University School and Hospital of
      Stomatology, Beijing, PR China.
FAU - Cai, Q
AU  - Cai Q
FAU - Liu, H
AU  - Liu H
FAU - Heng, B C
AU  - Heng BC
FAU - Peng, H
AU  - Peng H
FAU - Song, Y
AU  - Song Y
FAU - Yang, Z
AU  - Yang Z
FAU - Deng, X
AU  - Deng X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120614
PL  - Denmark
TA  - Int J Oral Maxillofac Surg
JT  - International journal of oral and maxillofacial surgery
JID - 8605826
SB  - IM
MH  - Animals
MH  - *Antlers
MH  - *Bone Regeneration
MH  - Mandible/*anatomy & histology
MH  - Microscopy, Electron, Scanning
MH  - *Models, Biological
MH  - Rabbits
MH  - Tomography, X-Ray Computed
MH  - X-Ray Diffraction
EDAT- 2012/06/19 06:00
MHDA- 2013/06/05 06:00
CRDT- 2012/06/19 06:00
PHST- 2011/12/08 00:00 [received]
PHST- 2012/03/22 00:00 [revised]
PHST- 2012/05/14 00:00 [accepted]
PHST- 2012/06/19 06:00 [entrez]
PHST- 2012/06/19 06:00 [pubmed]
PHST- 2013/06/05 06:00 [medline]
AID - S0901-5027(12)00216-0 [pii]
AID - 10.1016/j.ijom.2012.05.014 [doi]
PST - ppublish
SO  - Int J Oral Maxillofac Surg. 2012 Nov;41(11):1330-7. doi:
      10.1016/j.ijom.2012.05.014. Epub 2012 Jun 14.


PMID- 22702330
OWN - NLM
STAT- MEDLINE
DCOM- 20120910
LR  - 20120703
IS  - 1933-0715 (Electronic)
IS  - 1933-0707 (Linking)
VI  - 10
IP  - 1
DP  - 2012 Jul
TI  - Anaplastic medulloblastoma in a child with Duchenne muscular dystrophy.
PG  - 21-4
LID - 10.3171/2012.3.PEDS11152 [doi]
AB  - A 9-year-old boy with known Duchenne type muscular dystrophy (DMD) presented with
      signs of increased intracranial pressure. Radiological investigations revealed a 
      lesion in the midline of the posterior fossa. Subtotal resection was performed.
      Pathology findings were consistent with the diagnosis of anaplastic
      medulloblastoma. The postoperative lumbar CSF was positive for malignant cells.
      Postoperatively, the patient showed severe neurological deterioration and lost
      his capacity to walk. He was treated with craniospinal radiation followed by
      nonintensive chemotherapy. At 30 months postsurgery, he was still in complete
      remission but had not recovered his walking ability. This is the second report of
      a malignant brain tumor in a boy with DMD. The possible link between the 2
      conditions is discussed, as are ethical considerations regarding the management
      of medulloblastoma in children with DMD.
FAU - van den Akker, Machiel
AU  - van den Akker M
AD  - Division of Haematology/Oncology, Hospital for Sick Children, University of
      Toronto, Ontario, Canada. machielvdakker@gmail.com
FAU - Northcott, Paul
AU  - Northcott P
FAU - Taylor, Michael D
AU  - Taylor MD
FAU - Halliday, William
AU  - Halliday W
FAU - Bartels, Ute
AU  - Bartels U
FAU - Bouffet, Eric
AU  - Bouffet E
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20120615
PL  - United States
TA  - J Neurosurg Pediatr
JT  - Journal of neurosurgery. Pediatrics
JID - 101463759
SB  - IM
MH  - Cerebellar Neoplasms/complications/*diagnosis/drug
      therapy/physiopathology/radiotherapy/*surgery
MH  - Cerebrospinal Fluid
MH  - Chemotherapy, Adjuvant
MH  - Child
MH  - Humans
MH  - Intracranial Hypertension
MH  - Male
MH  - Medulloblastoma/complications/*diagnosis/drug
      therapy/physiopathology/radiotherapy/*surgery
MH  - Muscular Dystrophy, Duchenne/*complications
MH  - Radiotherapy, Adjuvant
MH  - Spinal Puncture
MH  - Treatment Outcome
MH  - Walking
EDAT- 2012/06/19 06:00
MHDA- 2012/09/11 06:00
CRDT- 2012/06/19 06:00
PHST- 2012/06/19 06:00 [entrez]
PHST- 2012/06/19 06:00 [pubmed]
PHST- 2012/09/11 06:00 [medline]
AID - 10.3171/2012.3.PEDS11152 [doi]
PST - ppublish
SO  - J Neurosurg Pediatr. 2012 Jul;10(1):21-4. doi: 10.3171/2012.3.PEDS11152. Epub
      2012 Jun 15.


PMID- 22702076
OWN - NLM
STAT- MEDLINE
DCOM- 20120705
LR  - 20161206
IS  - 1210-7832 (Print)
IS  - 1210-7832 (Linking)
VI  - 77
IP  - 2
DP  - 2012 Apr
TI  - [Medical, legal and ethical aspects of fertility preservation in cancer
      survivor].
PG  - 163-6
AB  - In recent years the number of the young women in fertile age which are
      oncologically treated is increasing. For these women chemotherapy and
      radiotherapy introduces potential risk of reproductive dysfunctions. Present
      techniques of assisted reproduction are offering possibilities to save
      reproductive functions even after the oncological treatment. As a perspective
      outlook seems to be frozen premature oocytes with IVM and fertilisation. With
      these fertility savings methods are naturally coming up some of the ethical and
      legal issues.
FAU - Zahumensky, J
AU  - Zahumensky J
AD  - Gynekologicko-porodnicka klinika 3. LF UK a FN KV. jozef.zahumensky@fnkv.cz
FAU - Kucera, E
AU  - Kucera E
FAU - Kosova, T
AU  - Kosova T
FAU - Zmrhal, J
AU  - Zmrhal J
FAU - Stejskal, M
AU  - Stejskal M
FAU - Stejskal, D
AU  - Stejskal D
LA  - cze
PT  - English Abstract
PT  - Journal Article
TT  - Medicinske, pravni a eticke aspekty zachovani fertility u onkologickych
      pacientek.
PL  - Czech Republic
TA  - Ceska Gynekol
JT  - Ceska gynekologie
JID - 9423768
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Antineoplastic Agents/*adverse effects
MH  - Blastocyst
MH  - Cryopreservation
MH  - Female
MH  - *Fertility Preservation/ethics/legislation & jurisprudence
MH  - Humans
MH  - Neoplasms/*drug therapy
MH  - Oocytes
MH  - Ovary
MH  - Pregnancy
MH  - Primary Ovarian Insufficiency/chemically induced
MH  - *Survivors
EDAT- 2012/06/19 06:00
MHDA- 2012/07/06 06:00
CRDT- 2012/06/19 06:00
PHST- 2012/06/19 06:00 [entrez]
PHST- 2012/06/19 06:00 [pubmed]
PHST- 2012/07/06 06:00 [medline]
PST - ppublish
SO  - Ceska Gynekol. 2012 Apr;77(2):163-6.


PMID- 22701825
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2229-5488 (Electronic)
IS  - 2229-3485 (Linking)
VI  - 3
IP  - 2
DP  - 2012 Apr
TI  - Accreditation of human research protection program: An Indian perspective.
PG  - 80-4
LID - 10.4103/2229-3485.96455 [doi]
AB  - With the increasing number of clinical trials being placed in India, it is the
      collective responsibility of the Investigator sites, Government, Ethics
      Committees, and Sponsors to ensure that the trial subjects are protected from
      risks these studies can have, that subjects are duly compensated, and credible
      data generated. Most importantly, each institution/hospital should have a strong 
      Human Research Protection Program to safe guard the trial subjects. In order to
      look at research with a comprehensive objective approach, there is a need for a
      formal auditing and review system by a recognized body. As of now, only the
      sponsors are monitoring/auditing their respective trials; however, there is an
      increasing need to perform a more detailed review and assessment of processes of 
      the institution and the Ethics Committee. This challenge can be addressed by
      going for accreditation by a reputed association that encompasses-the
      institutions, the ethics committees, and researcher/research staff. Starting
      their journey for the accreditation process in late 2010, Kasturba Medical
      College and Hospital [KMC], Manipal, and Manipal Hospital Bangalore [MHB]
      received full Association for the Accreditation of Human Research Protection
      Programs (AAHRPP) accreditation in Dec 2011-a first in India. This article delves
      into the steps involved in applying for AAHRPP accreditation from an Indian
      Perspective, the challenges, advantages, and testimonials from the two hospitals 
      on the application experience and how the accreditation has improved the Human
      Research Protection Program at these hospitals.
FAU - Bairy, K L
AU  - Bairy KL
AD  - Department of Pharmacology, Kasturba Hospital, Manipal, Bangalore, Karnataka,
      India.
FAU - Pereira, Pratibha
AU  - Pereira P
LA  - eng
PT  - Journal Article
PL  - India
TA  - Perspect Clin Res
JT  - Perspectives in clinical research
JID - 101551517
PMC - PMC3371553
OTO - NOTNLM
OT  - Accreditation
OT  - Association for the Accreditation of Human Research Protection Programs
OT  - ethical clinical trials
OT  - human research protection
OT  - subject protection
EDAT- 2012/06/16 06:00
MHDA- 2012/06/16 06:01
CRDT- 2012/06/16 06:00
PHST- 2012/06/16 06:00 [entrez]
PHST- 2012/06/16 06:00 [pubmed]
PHST- 2012/06/16 06:01 [medline]
AID - 10.4103/2229-3485.96455 [doi]
AID - PCR-3-80 [pii]
PST - ppublish
SO  - Perspect Clin Res. 2012 Apr;3(2):80-4. doi: 10.4103/2229-3485.96455.


PMID- 22701824
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2229-5488 (Electronic)
IS  - 2229-3485 (Linking)
VI  - 3
IP  - 2
DP  - 2012 Apr
TI  - US food and drug administration Indian site inspections: An experience.
PG  - 73-9
LID - 10.4103/2229-3485.96453 [doi]
AB  - Since 2005, USFDA has begun inspections of Indian clinical trial investigator
      sites. This paper reports experience of an FDA inspection performed at two Indian
      centers. The inspection started with an in-depth discussion with the investigator
      and his team about the conduct of the clinical trial at the site and was followed
      by a tour of the important locations - registration, outpatient department,
      specialty clinic, medical record section, and special procedure department. The
      inspector reviewed the critical processes - protocol compliance, ethics committee
      approval, informed consent process, case record form and source documents
      completion, investigational product accountability, serious adverse events
      documentation and reporting. The inspector reviewed all documents from the
      investigator site file and conducted audit of all subjects enrolled at both the
      sites. As the Indian sites are not exposed to regulatory inspections, it is vital
      for the sponsor to conduct preinspection audit, provide training and support to
      face the FDA inspection.
FAU - Mahajan, Pooja
AU  - Mahajan P
AD  - Clininvent Research Pvt Ltd, Mumbai, India.
FAU - D'Souza, Natasha
AU  - D'Souza N
FAU - Bhatt, Arun
AU  - Bhatt A
FAU - Halbe, Vipul
AU  - Halbe V
FAU - Sharma, Richa
AU  - Sharma R
FAU - Narayanswamy, Shweta
AU  - Narayanswamy S
FAU - Bughediwala, Murtuza
AU  - Bughediwala M
LA  - eng
PT  - Journal Article
PL  - India
TA  - Perspect Clin Res
JT  - Perspectives in clinical research
JID - 101551517
PMC - PMC3371552
OTO - NOTNLM
OT  - Documents
OT  - GCP
OT  - inspection
OT  - process
OT  - training
EDAT- 2012/06/16 06:00
MHDA- 2012/06/16 06:01
CRDT- 2012/06/16 06:00
PHST- 2012/06/16 06:00 [entrez]
PHST- 2012/06/16 06:00 [pubmed]
PHST- 2012/06/16 06:01 [medline]
AID - 10.4103/2229-3485.96453 [doi]
AID - PCR-3-73 [pii]
PST - ppublish
SO  - Perspect Clin Res. 2012 Apr;3(2):73-9. doi: 10.4103/2229-3485.96453.


PMID- 22701823
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2229-5488 (Electronic)
IS  - 2229-3485 (Linking)
VI  - 3
IP  - 2
DP  - 2012 Apr
TI  - Health technology assessment and its role in the future development of the Indian
      healthcare sector.
PG  - 66-72
LID - 10.4103/2229-3485.96449 [doi]
AB  - Public expenditure on healthcare in India is low by international comparison, and
      access to essential treatment pushes many uninsured citizens below the poverty
      line. In many countries, policymakers utilize health technology assessment (HTA) 
      methodologies to direct investments in healthcare, to obtain the maximum benefit 
      for the population as a whole. With rising incomes and a commitment from the
      Government of India to increase the proportion of gross domestic product spent on
      health, this is an opportune moment to consider how HTA might help to allocate
      healthcare spending in India, in an equitable and efficient manner. Despite the
      predominance of out-of-pocket payments in the Indian healthcare sector, payers of
      all types are increasingly demanding value for money from expenditure on
      healthcare. In this review we demonstrate how HTA can be used to inform several
      aspects of healthcare provision. Areas in which HTA could be applied in the
      Indian context include, drug pricing, development of clinical practice
      guidelines, and prioritizing interventions that represent the greatest value
      within a limited budget. To illustrate the potential benefits of using the HTA
      approach, we present an example from a mature HTA market (Canada) that
      demonstrates how a new treatment for patients with atrial fibrillation - although
      more expensive than the current standard of care - improves clinical outcomes and
      represents a cost-effective use of public health resources. If aligned with the
      prevailing cultural and ethical considerations, and with the necessary investment
      in expert staff and resources, HTA promises to be a valuable tool for development
      of the Indian healthcare sector.
FAU - Hass, Bastian
AU  - Hass B
AD  - Boehringer Ingelheim GmbH, Binger Strasse 173, 55216 Ingelheim am Rhein, Germany.
FAU - Pooley, Jayne
AU  - Pooley J
FAU - Feuring, Martin
AU  - Feuring M
FAU - Suvarna, Viraj
AU  - Suvarna V
FAU - Harrington, Adrian E
AU  - Harrington AE
LA  - eng
PT  - Journal Article
PL  - India
TA  - Perspect Clin Res
JT  - Perspectives in clinical research
JID - 101551517
PMC - PMC3371551
OTO - NOTNLM
OT  - Cost-effectiveness
OT  - India
OT  - health technology assessment
OT  - pricing
OT  - reimbursement
EDAT- 2012/06/16 06:00
MHDA- 2012/06/16 06:01
CRDT- 2012/06/16 06:00
PHST- 2012/06/16 06:00 [entrez]
PHST- 2012/06/16 06:00 [pubmed]
PHST- 2012/06/16 06:01 [medline]
AID - 10.4103/2229-3485.96449 [doi]
AID - PCR-3-66 [pii]
PST - ppublish
SO  - Perspect Clin Res. 2012 Apr;3(2):66-72. doi: 10.4103/2229-3485.96449.


PMID- 22701821
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20220408
IS  - 2229-5488 (Electronic)
IS  - 2229-3485 (Linking)
VI  - 3
IP  - 2
DP  - 2012 Apr
TI  - Awareness about medical research among resident doctors in a tertiary care
      hospital: A cross-sectional survey.
PG  - 57-61
LID - 10.4103/2229-3485.96446 [doi]
AB  - CONTEXT: Every medical practitioner should strive to contribute to the generation
      of evidence by conducting research. For carrying out research, adequate
      knowledge, practical skills, and development of the right attitude are crucial. A
      literature review shows that data regarding knowledge, attitude, and practices
      toward medical research, among resident doctors in India, is lacking. AIMS: This 
      study was conducted to assess research-related knowledge, attitude, and practices
      among resident doctors. SETTINGS AND DESIGN: A cross-sectional survey was
      conducted using a pretested, structured, and pre-validated questionnaire.
      MATERIALS AND METHODS: With approval of the Institutional Ethics Committee and a 
      verbal consent, a cross-sectional survey among 100 resident doctors pursuing
      their second and third years in the MD and MS courses was conducted using a
      structured and pre-validated questionnaire. STATISTICAL ANALYSIS: Descriptive
      statistics were used to analyze the results. RESULTS: The concept of research
      hypothesis was known to 58% of the residents. Ninety-eight percent of the
      residents were aware of the procedure to obtain informed consent. Seventy-six
      percent agreed that research training should be mandatory. Although 88% of the
      residents were interested in conducting research in future, 50% had participated 
      in research other than a dissertation project, 28% had made scientific
      presentations, and only 4% had publications. Lack of time (74%), lack of research
      curriculum (42%), and inadequate facilities (38%) were stated as major obstacles 
      for pursuing research. CONCLUSIONS: Although resident doctors demonstrated a
      fairly good knowledge and positive attitude toward research, it did not translate
      into practice for most of them. There is a need to improve the existing medical
      education system to foster research culture among resident doctors.
FAU - Pawar, Dattatray B
AU  - Pawar DB
AD  - Department of Pharmacology and Therapeutics, Seth Gordhandas Sundardas Medical
      College and King Edward Memorial Hospital, Mumbai, Maharashtra, India.
FAU - Gawde, Suchita R
AU  - Gawde SR
FAU - Marathe, Padmaja A
AU  - Marathe PA
LA  - eng
PT  - Journal Article
PL  - India
TA  - Perspect Clin Res
JT  - Perspectives in clinical research
JID - 101551517
PMC - PMC3371549
OTO - NOTNLM
OT  - Attitude
OT  - knowledge
OT  - postgraduate student
OT  - practice
OT  - research
OT  - residency curriculum
EDAT- 2012/06/16 06:00
MHDA- 2012/06/16 06:01
CRDT- 2012/06/16 06:00
PHST- 2012/06/16 06:00 [entrez]
PHST- 2012/06/16 06:00 [pubmed]
PHST- 2012/06/16 06:01 [medline]
AID - 10.4103/2229-3485.96446 [doi]
AID - PCR-3-57 [pii]
PST - ppublish
SO  - Perspect Clin Res. 2012 Apr;3(2):57-61. doi: 10.4103/2229-3485.96446.


PMID- 22701820
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2229-5488 (Electronic)
IS  - 2229-3485 (Linking)
VI  - 3
IP  - 2
DP  - 2012 Apr
TI  - Ethics committees in India: Facing the challenges!
PG  - 50-6
LID - 10.4103/2229-3485.96444 [doi]
AB  - The past few years have seen a tremendous rise in the number of clinical trials
      conducted in India. This is been attributed to the huge patient population,
      genetic diversity, and rich technical pool in our country. However, the
      economical upsurge in the clinical trial industry has also caused concerns
      pertaining to the efficiency of the Regulatory Agencies and Ethics Committees
      (EC). The EC plays an important role in the regulation of clinical research at
      the local level. However, it is seen that many ECs are oblivious to their roles
      and responsibilities. It is reported that ECs lack standard operating procedures,
      do not have a proper composition or adequate representation, thus affecting their
      functions in regulating clinical research. Moreover, ECs seem to function in
      isolation, as self-sufficient bodies, having no communication with the regulatory
      agency or other ECs. This brings forth the need for ECs to come together and
      share their experiences and observations, with the aim of updating themselves and
      refining their functions. Efforts also need to be focused on capacity building,
      centralized registration of ECs, and bringing an oversight mechanism in place.
      The Ethics Committees in India need to work in close association with forums such
      as the Forum for Ethics Review Committees in India and the Forum for Ethical
      Review Committees in Asia Pacific, in an effort towards empowering themselves.
FAU - Kadam, Rashmi
AU  - Kadam R
AD  - Quality Assurance Manager, Chest Research Foundation Pune, India.
FAU - Karandikar, Shashikant
AU  - Karandikar S
LA  - eng
PT  - Journal Article
PL  - India
TA  - Perspect Clin Res
JT  - Perspectives in clinical research
JID - 101551517
PMC - PMC3371548
OTO - NOTNLM
OT  - Collaborative
OT  - capacity building
OT  - central registration
OT  - ethics committees
OT  - oversight mechanism
EDAT- 2012/06/16 06:00
MHDA- 2012/06/16 06:01
CRDT- 2012/06/16 06:00
PHST- 2012/06/16 06:00 [entrez]
PHST- 2012/06/16 06:00 [pubmed]
PHST- 2012/06/16 06:01 [medline]
AID - 10.4103/2229-3485.96444 [doi]
AID - PCR-3-50 [pii]
PST - ppublish
SO  - Perspect Clin Res. 2012 Apr;3(2):50-6. doi: 10.4103/2229-3485.96444.


PMID- 22701407
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1662-5153 (Electronic)
IS  - 1662-5153 (Linking)
VI  - 6
DP  - 2012
TI  - A rat model of post-traumatic stress disorder reproduces the hippocampal deficits
      seen in the human syndrome.
PG  - 26
LID - 10.3389/fnbeh.2012.00026 [doi]
AB  - Despite recent progress, the causes and pathophysiology of post-traumatic stress 
      disorder (PTSD) remain poorly understood, partly because of ethical limitations
      inherent to human studies. One approach to circumvent this obstacle is to study
      PTSD in a valid animal model of the human syndrome. In one such model, extreme
      and long-lasting behavioral manifestations of anxiety develop in a subset of
      Lewis rats after exposure to an intense predatory threat that mimics the type of 
      life-and-death situation known to precipitate PTSD in humans. This study aimed to
      assess whether the hippocampus-associated deficits observed in the human syndrome
      are reproduced in this rodent model. Prior to predatory threat, different groups 
      of rats were each tested on one of three object recognition memory tasks that
      varied in the types of contextual clues (i.e., that require the hippocampus or
      not) the rats could use to identify novel items. After task completion, the rats 
      were subjected to predatory threat and, one week later, tested on the elevated
      plus maze (EPM). Based on their exploratory behavior in the plus maze, rats were 
      then classified as resilient or PTSD-like and their performance on the pre-threat
      object recognition tasks compared. The performance of PTSD-like rats was inferior
      to that of resilient rats but only when subjects relied on an allocentric frame
      of reference to identify novel items, a process thought to be critically
      dependent on the hippocampus. Therefore, these results suggest that even prior to
      trauma PTSD-like rats show a deficit in hippocampal-dependent functions, as
      reported in twin studies of human PTSD.
FAU - Goswami, Sonal
AU  - Goswami S
AD  - Center for Molecular and Behavioral Neuroscience, Rutgers State University,
      Newark NJ, USA.
FAU - Samuel, Sherin
AU  - Samuel S
FAU - Sierra, Olga R
AU  - Sierra OR
FAU - Cascardi, Michele
AU  - Cascardi M
FAU - Pare, Denis
AU  - Pare D
LA  - eng
GR  - R01 MH083710/MH/NIMH NIH HHS/United States
PT  - Journal Article
DEP - 20120612
PL  - Switzerland
TA  - Front Behav Neurosci
JT  - Frontiers in behavioral neuroscience
JID - 101477952
PMC - PMC3372979
OTO - NOTNLM
OT  - animal model
OT  - elevated plus maze
OT  - extinction
OT  - open field
OT  - post-traumatic stress disorder
OT  - predatory threat
OT  - recognition memory
EDAT- 2012/06/16 06:00
MHDA- 2012/06/16 06:01
CRDT- 2012/06/16 06:00
PHST- 2012/04/19 00:00 [received]
PHST- 2012/05/24 00:00 [accepted]
PHST- 2012/06/16 06:00 [entrez]
PHST- 2012/06/16 06:00 [pubmed]
PHST- 2012/06/16 06:01 [medline]
AID - 10.3389/fnbeh.2012.00026 [doi]
PST - epublish
SO  - Front Behav Neurosci. 2012 Jun 12;6:26. doi: 10.3389/fnbeh.2012.00026.
      eCollection 2012.


PMID- 22701302
OWN - NLM
STAT- MEDLINE
DCOM- 20140317
LR  - 20211021
IS  - 1110-7251 (Electronic)
IS  - 1110-7243 (Linking)
VI  - 2012
DP  - 2012
TI  - Advancement in the development of models for hepatitis C research.
PG  - 346761
LID - 10.1155/2012/346761 [doi]
AB  - Hepatitis C virus (HCV) is a pandemic disease affecting an estimated 180 million 
      individuals worldwide and infecting each year another ~3-4 million people making 
      HCV a global public health issue. HCV is the main cause for chronic hepatitis,
      cirrhosis, and hepatocellular carcinoma. In the United States, HCV-related
      chronic liver disease is a leading cause of liver transplantation. Despite
      significant improvements in antiviral drugs, only ~50% of treated patients with
      HCV have viral clearance after treatment. Showing unique species specificity, HCV
      has a narrow range of potential hosts infecting only chimpanzees and humans. For 
      decades, the chimpanzee model has been the only and instrumental primate for
      studying HCV infection; however, availability, economic, and ethical issues make 
      the chimpanzee an unsuitable animal model today. Thus, significant research has
      been devoted to explore different models that are suitable in studying the
      biology of the virus and application in the clinical research for developing
      efficient and tolerable treatments for patients. This review focuses on
      experimental models that have been developed to date and their findings related
      to HCV.
FAU - Carcamo, Wendy C
AU  - Carcamo WC
AD  - Department of Oral Biology, University of Florida, 1395 Center Drive,
      Gainesville, FL 32610, USA.
FAU - Nguyen, Cuong Q
AU  - Nguyen CQ
LA  - eng
GR  - K99 DE018958/DE/NIDCR NIH HHS/United States
GR  - R00 DE018958/DE/NIDCR NIH HHS/United States
GR  - K99/R00 DE018958/DE/NIDCR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120530
PL  - United States
TA  - J Biomed Biotechnol
JT  - Journal of biomedicine & biotechnology
JID - 101135740
RN  - 0 (Antiviral Agents)
SB  - IM
MH  - Animals
MH  - Antiviral Agents/pharmacology
MH  - Cell Line
MH  - *Disease Models, Animal
MH  - Hepacivirus/*genetics/pathogenicity
MH  - Hepatitis C/*genetics/pathology/virology
MH  - Humans
MH  - Mice
MH  - Pan troglodytes/genetics
MH  - United States
PMC - PMC3369559
EDAT- 2012/06/16 06:00
MHDA- 2014/03/19 06:00
CRDT- 2012/06/16 06:00
PHST- 2012/01/18 00:00 [received]
PHST- 2012/04/02 00:00 [accepted]
PHST- 2012/06/16 06:00 [entrez]
PHST- 2012/06/16 06:00 [pubmed]
PHST- 2014/03/19 06:00 [medline]
AID - 10.1155/2012/346761 [doi]
PST - ppublish
SO  - J Biomed Biotechnol. 2012;2012:346761. doi: 10.1155/2012/346761. Epub 2012 May
      30.


PMID- 22700392
OWN - NLM
STAT- MEDLINE
DCOM- 20130419
LR  - 20211021
IS  - 1525-1497 (Electronic)
IS  - 0884-8734 (Linking)
VI  - 27
IP  - 11
DP  - 2012 Nov
TI  - The validity of using analogue patients in practitioner-patient communication
      research: systematic review and meta-analysis.
PG  - 1528-43
LID - 10.1007/s11606-012-2111-8 [doi]
AB  - When studying the patient perspective on communication, some studies rely on
      analogue patients (patients and healthy subjects) who rate videotaped medical
      consultations while putting themselves in the shoes of the video-patient. To
      describe the rationales, methodology, and outcomes of studies using
      video-vignette designs in which videotaped medical consultations are watched and 
      judged by analogue patients. Pubmed, Embase, Psychinfo and CINAHL databases were 
      systematically searched up to February 2012. Data was extracted on: study
      characteristics and quality, design, rationales, internal and external validity, 
      limitations and analogue patients' perceptions of studied communication. A
      meta-analysis was conducted on the distribution of analogue patients' evaluations
      of communication. Thirty-four studies were included, comprising both scripted and
      clinical studies, of average-to-superior quality. Studies provided unspecific,
      ethical as well as methodological rationales for conducting video-vignette
      studies with analogue patients. Scripted studies provided the most specific
      methodological rationales and tried the most to increase and test internal
      validity (e.g. by performing manipulation checks) and external validity (e.g. by 
      determining identification with video-patient). Analogue patients' perceptions of
      communication largely overlap with clinical patients' perceptions. The
      meta-analysis revealed that analogue patients' evaluations of practitioners'
      communication are not subject to ceiling effects. Analogue patients' evaluations 
      of communication equaled clinical patients' perceptions, while overcoming ceiling
      effects. This implies that analogue patients can be included as proxies for
      clinical patients in studies on communication, taken some described precautions
      into account. Insights from this review may ease decisions about including
      analogue patients in video-vignette studies, improve the quality of these studies
      and increase knowledge on communication from the patient perspective.
FAU - van Vliet, Liesbeth M
AU  - van Vliet LM
AD  - NIVEL (Netherlands Institute for Health Services Research), PO box 1568, 3500 BN,
      Utrecht, The Netherlands. l.vanvliet@nivel.nl
FAU - van der Wall, Elsken
AU  - van der Wall E
FAU - Albada, Akke
AU  - Albada A
FAU - Spreeuwenberg, Peter M M
AU  - Spreeuwenberg PM
FAU - Verheul, William
AU  - Verheul W
FAU - Bensing, Jozien M
AU  - Bensing JM
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20120615
PL  - United States
TA  - J Gen Intern Med
JT  - Journal of general internal medicine
JID - 8605834
SB  - IM
MH  - *Communication
MH  - Humans
MH  - *Patient Preference
MH  - *Patient Simulation
MH  - *Physician-Patient Relations
MH  - Reproducibility of Results
MH  - *Videotape Recording
PMC - PMC3475831
EDAT- 2012/06/16 06:00
MHDA- 2013/04/23 06:00
CRDT- 2012/06/16 06:00
PHST- 2011/11/15 00:00 [received]
PHST- 2012/05/03 00:00 [accepted]
PHST- 2012/04/11 00:00 [revised]
PHST- 2012/06/16 06:00 [entrez]
PHST- 2012/06/16 06:00 [pubmed]
PHST- 2013/04/23 06:00 [medline]
AID - 10.1007/s11606-012-2111-8 [doi]
PST - ppublish
SO  - J Gen Intern Med. 2012 Nov;27(11):1528-43. doi: 10.1007/s11606-012-2111-8. Epub
      2012 Jun 15.


PMID- 22700259
OWN - NLM
STAT- MEDLINE
DCOM- 20121119
LR  - 20211021
IS  - 1748-880X (Electronic)
IS  - 0007-1285 (Linking)
VI  - 85
IP  - 1018
DP  - 2012 Oct
TI  - High-intensity focused ultrasound treatment of liver tumours: post-treatment MRI 
      correlates well with intra-operative estimates of treatment volume.
PG  - 1363-70
LID - 10.1259/bjr/56737365 [doi]
AB  - OBJECTIVES: To assess the safety and feasibility of high-intensity focused
      ultrasound (HIFU) ablation of liver tumours and to determine whether
      post-operative MRI correlates with intra-operative imaging. METHODS: 31 patients 
      were recruited into two ethically approved clinical trials (median age 64; mean
      BMI 26 kg m(-2)). Patients with liver tumours (primary or metastatic) underwent a
      single HIFU treatment monitored using intra-operative B-mode ultrasound.
      Follow-up consisted of radiology and histology (surgical trial) or radiology
      alone (radiology trial). Radiological follow-up was digital subtraction
      contrast-enhanced MRI. RESULTS: Treatment according to protocol was possible in
      30 of 31 patients. One treatment was abandoned because of equipment failure.
      Transient pain and superficial skin burns were seen in 81% (25/31) and 39%
      (12/31) of patients, respectively. One moderate skin burn occurred. One patient
      died prior to radiological follow-up. Radiological evidence of ablation was seen 
      in 93% (27/29) of patients. Ablation accuracy was good in 89% (24/27) of
      patients. In three patients the zone of ablation lay </=2 mm outside the tumour. 
      The median cross-sectional area (CSA) of the zone of ablation was 5.0 and 5.1
      cm(2) using intra-operative and post-operative imaging, respectively. The mean
      MRI:B-mode CSA ratio was 1.57 [95% confidence interval (CI)=0.57-2.71]. There was
      positive correlation between MRI and B-mode CSA (Spearman's r=0.48; 95% CI
      0.11-0.73; p=0.011) and the slope of linear regression was significantly non-zero
      (1.23; 95% CI=0.68-1.77; p<0.0001). CONCLUSIONS: HIFU ablation of liver tumours
      is safe and feasible. HIFU treatment is accurate, and intra-operative assessment 
      of treatment provides an accurate measure of the zone of ablation and correlates 
      well with MRI follow-up.
FAU - Leslie, T
AU  - Leslie T
AD  - Oxford Clinical HIFU Unit, Churchill Hospital, Oxford, UK.
FAU - Ritchie, R
AU  - Ritchie R
FAU - Illing, R
AU  - Illing R
FAU - Ter Haar, G
AU  - Ter Haar G
FAU - Phillips, R
AU  - Phillips R
FAU - Middleton, M
AU  - Middleton M
FAU - Bch, Bm
AU  - Bch B
FAU - Wu, F
AU  - Wu F
FAU - Cranston, D
AU  - Cranston D
LA  - eng
GR  - Cancer Research UK/United Kingdom
PT  - Clinical Trial
PT  - Clinical Trial, Phase II
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120614
PL  - England
TA  - Br J Radiol
JT  - The British journal of radiology
JID - 0373125
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Feasibility Studies
MH  - Female
MH  - High-Intensity Focused Ultrasound Ablation/adverse effects/*methods
MH  - Humans
MH  - Intraoperative Care/methods
MH  - Liver Neoplasms/pathology/*therapy
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Middle Aged
MH  - Postoperative Care/methods
MH  - Prospective Studies
MH  - Treatment Outcome
PMC - PMC3474034
EDAT- 2012/06/16 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/06/16 06:00
PHST- 2012/06/16 06:00 [entrez]
PHST- 2012/06/16 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 56737365 [pii]
AID - 10.1259/bjr/56737365 [doi]
PST - ppublish
SO  - Br J Radiol. 2012 Oct;85(1018):1363-70. doi: 10.1259/bjr/56737365. Epub 2012 Jun 
      14.


PMID- 22699939
OWN - NLM
STAT- MEDLINE
DCOM- 20121109
LR  - 20211021
IS  - 1469-3178 (Electronic)
IS  - 1469-221X (Linking)
VI  - 13
IP  - 7
DP  - 2012 Jun 29
TI  - Engineering and ethical perspectives in synthetic biology. Rigorous, robust and
      predictable designs, public engagement and a modern ethical framework are vital
      to the continued success of synthetic biology.
PG  - 584-90
LID - 10.1038/embor.2012.81 [doi]
FAU - Anderson, James
AU  - Anderson J
AD  - Department of Engineering Science, University of Oxford, UK.
FAU - Strelkowa, Natalja
AU  - Strelkowa N
FAU - Stan, Guy-Bart
AU  - Stan GB
FAU - Douglas, Thomas
AU  - Douglas T
FAU - Savulescu, Julian
AU  - Savulescu J
FAU - Barahona, Mauricio
AU  - Barahona M
FAU - Papachristodoulou, Antonis
AU  - Papachristodoulou A
LA  - eng
GR  - 080711/Z/06/Z/WT_/Wellcome Trust/United Kingdom
GR  - BB/F018479/1/BB_/Biotechnology and Biological Sciences Research Council/United
      Kingdom
GR  - WT_/Wellcome Trust/United Kingdom
GR  - WT087211/WT_/Wellcome Trust/United Kingdom
GR  - BB/G020434/1/BB_/Biotechnology and Biological Sciences Research Council/United
      Kingdom
GR  - 086041/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120629
PL  - England
TA  - EMBO Rep
JT  - EMBO reports
JID - 100963049
SB  - IM
MH  - *Bioethical Issues
MH  - Biotechnology
MH  - Genetic Engineering
MH  - Models, Biological
MH  - Research Design
MH  - Synthetic Biology/economics/methods/*trends
PMC - PMC3389334
EDAT- 2012/06/16 06:00
MHDA- 2012/11/10 06:00
CRDT- 2012/06/16 06:00
PHST- 2012/06/16 06:00 [entrez]
PHST- 2012/06/16 06:00 [pubmed]
PHST- 2012/11/10 06:00 [medline]
AID - embor201281 [pii]
AID - 10.1038/embor.2012.81 [doi]
PST - epublish
SO  - EMBO Rep. 2012 Jun 29;13(7):584-90. doi: 10.1038/embor.2012.81.


PMID- 22699803
OWN - NLM
STAT- MEDLINE
DCOM- 20130109
LR  - 20131121
IS  - 1432-0584 (Electronic)
IS  - 0939-5555 (Linking)
VI  - 91
IP  - 11
DP  - 2012 Nov
TI  - Phytohemagglutinin-activated human T cells induce lethal graft-versus-host
      disease in cyclophosphamide and anti-CD122 conditioned NOD/SCID mice.
PG  - 1803-12
LID - 10.1007/s00277-012-1505-3 [doi]
AB  - Graft-versus-host disease (GVHD) is a common complication after allogeneic
      hematopoietic stem cell transplantation. Much of our knowledge regarding GVHD
      comes from experiments on the mouse hematopoietic system due to ethical and
      technical constraints. Thus, in vivo GVHD models of the human immune system are
      required. In this study, we report an effective and reliable protocol for
      xenogeneic GVHD (xeno-GVHD) model induction using NOD/SCID mice, in which mice
      underwent a conditioning regimen consisting of intraperitoneal injection of
      cyclophosphamide and anti-CD122, followed by transfusion of
      phytohemagglutinin-activated human peripheral blood mononuclear cells containing 
      1 x 10(7) T cells, which has not been reported previously. The present model can 
      be utilized to study human immune cell function in vivo and elucidate the
      mechanisms underlying the pathogenesis of human GVHD. In addition, this model
      system can help researchers to rapidly determine whether proposed therapeutic
      strategies for GVHD are efficient in vivo and will elucidate the underlying
      mechanisms of drugs and cells to be investigated. Furthermore, such a protocol
      will undoubtedly be very helpful to laboratories that have no available sources
      of irradiation.
FAU - Hu, Yongxian
AU  - Hu Y
AD  - Bone Marrow Transplantation Center, The First Affiliated Hospital, School of
      Medicine, Zhejiang University, Hangzhou, 310003, China.
FAU - Gu, Yanjun
AU  - Gu Y
FAU - Cui, Qu
AU  - Cui Q
FAU - Fu, Huarui
AU  - Fu H
FAU - Sheng, Lixia
AU  - Sheng L
FAU - Wu, Kangni
AU  - Wu K
FAU - Liu, Lizhen
AU  - Liu L
FAU - Fu, Shan
AU  - Fu S
FAU - Yu, Xiaohong
AU  - Yu X
FAU - Huang, He
AU  - Huang H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120615
PL  - Germany
TA  - Ann Hematol
JT  - Annals of hematology
JID - 9107334
RN  - 0 (Autoantibodies)
RN  - 0 (Il2rb protein, mouse)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Interleukin-2 Receptor beta Subunit)
RN  - 0 (Mitogens)
RN  - 0 (Phytohemagglutinins)
RN  - 8N3DW7272P (Cyclophosphamide)
SB  - IM
MH  - Animals
MH  - Autoantibodies/therapeutic use
MH  - Crosses, Genetic
MH  - Cyclophosphamide/therapeutic use
MH  - *Disease Models, Animal
MH  - Graft Survival
MH  - Graft vs Host Disease/*etiology/immunology/pathology
MH  - Humans
MH  - Immunosuppressive Agents/*therapeutic use
MH  - Interleukin-2 Receptor beta Subunit/*antagonists & inhibitors
MH  - *Lymphocyte Activation
MH  - Mice
MH  - Mice, Inbred NOD
MH  - Mice, SCID
MH  - Mitogens
MH  - Phytohemagglutinins
MH  - Specific Pathogen-Free Organisms
MH  - T-Lymphocytes/immunology/*transplantation
MH  - Transplantation Conditioning/*methods
MH  - Transplantation, Heterologous/immunology/methods
EDAT- 2012/06/16 06:00
MHDA- 2013/01/10 06:00
CRDT- 2012/06/16 06:00
PHST- 2012/01/31 00:00 [received]
PHST- 2012/06/04 00:00 [accepted]
PHST- 2012/06/16 06:00 [entrez]
PHST- 2012/06/16 06:00 [pubmed]
PHST- 2013/01/10 06:00 [medline]
AID - 10.1007/s00277-012-1505-3 [doi]
PST - ppublish
SO  - Ann Hematol. 2012 Nov;91(11):1803-12. doi: 10.1007/s00277-012-1505-3. Epub 2012
      Jun 15.


PMID- 22699723
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20190608
IS  - 1518-8345 (Electronic)
IS  - 0104-1169 (Linking)
VI  - 20
IP  - 2
DP  - 2012 Mar-Apr
TI  - The prevalence of musculoskeletal diseases among casual dock workers.
PG  - 243-50
LID - S0104-11692012000200005 [pii]
AB  - This study identified the prevalence of work-related musculoskeletal disorders
      among casual dockworkers. This is a retrospective and quantitative study, the
      data sources of which included the medical files of dockworkers from 2000 to
      2009. Data were collected in a medical service for dockworkers using a previously
      developed form; descriptive quantitative analysis was performed. Ethical aspects 
      were complied with. A total of 15.8% of the diagnoses identified among male
      workers referred to musculoskeletal disorders. Individuals older than 52 years of
      age and with more than 21 years working in the field predominated. The most
      frequent musculoskeletal diseases included low back pain (38.8%), tendinitis
      (19.7%), and neck pain (12.5%). These diseases can be prevented through health
      interventions, confirming the importance of developing clinical support in
      nursing in order to improve the quality of life of dockworkers.
FAU - Almeida, Marlise Capa Verde de
AU  - Almeida MC
AD  - Universidade Federal do Rio Grande, Rua Almirante Barroso 197, Rio Grande, RS,
      Brazil. marlisealmeida@msn.com
FAU - Cezar-Vaz, Marta Regina
AU  - Cezar-Vaz MR
FAU - Soares, Jorgana Fernanda de Souza
AU  - Soares JF
FAU - Silva, Mara Regina Santos da
AU  - Silva MR
LA  - eng
LA  - por
LA  - spa
PT  - Journal Article
PL  - Brazil
TA  - Rev Lat Am Enfermagem
JT  - Revista latino-americana de enfermagem
JID - 9420934
MH  - Brazil/epidemiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Musculoskeletal Diseases/*epidemiology
MH  - Occupational Diseases/*epidemiology
MH  - Prevalence
MH  - Retrospective Studies
MH  - *Weight-Bearing
EDAT- 2012/06/16 06:00
MHDA- 2012/11/14 06:00
CRDT- 2012/06/16 06:00
PHST- 2011/06/17 00:00 [received]
PHST- 2012/03/06 00:00 [accepted]
PHST- 2012/06/16 06:00 [entrez]
PHST- 2012/06/16 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
AID - S0104-11692012000200005 [pii]
AID - 10.1590/s0104-11692012000200005 [doi]
PST - ppublish
SO  - Rev Lat Am Enfermagem. 2012 Mar-Apr;20(2):243-50. doi:
      10.1590/s0104-11692012000200005.


PMID- 22699644
OWN - NLM
STAT- MEDLINE
DCOM- 20121030
LR  - 20190907
IS  - 1678-4561 (Electronic)
IS  - 1413-8123 (Linking)
VI  - 17
IP  - 6
DP  - 2012 Jun
TI  - [The green rural economy: challenges to research and to public health policies
      posed by agricultural modernization].
PG  - 1533-42
LID - S1413-81232012000600017 [pii]
AB  - In this paper, we ask ourselves who should, can and has the will to promote
      health in the rural zone today. The fields of science and public policy were
      chosen as our primary focus of dialogue conducted from the perspective of the
      right to health and a healthy environment. Seven lessons emerged: (1) in addition
      to the surveillance of isolated chemical risks, the relation between
      agrochemicals and health should be investigated in the context of conservative
      agricultural modernization; (2) it is mandatory and urgent to discover the health
      problems related to the use of agrochemicals; (3) the State has been successful
      in its support of agribusiness, but highly inefficient at enforcing policies to
      safeguard social rights; (4) sectors of society linked to rural organizations
      have played an important role in the public policies combating agrochemicals and 
      protecting health; (5) studies must help deconstruct the myths surrounding the
      Green Revolution model; (6) we are faced with the challenge of contributing to
      the construction of an emerging scientific paradigm founded on an
      ethical-political commitment to the most vulnerable social elements; (7) rural
      communities are creating agro-ecological alternatives for life in semiarid areas.
FAU - Rigotto, Raquel Maria
AU  - Rigotto RM
AD  - Nucleo Tramas, Departamento de Saude Comunitaria, Centro de Ciencias da Saude,
      Universidade Federal do Ceara, 60431-970 Fortaleza, CE. ntramas.ufc@gmail.com
FAU - Carneiro, Fernando Ferreira
AU  - Carneiro FF
FAU - Marinho, Alice Maria Correia Pequeno
AU  - Marinho AM
FAU - Rocha, Mayara Melo
AU  - Rocha MM
FAU - Ferreira, Marcelo Jose Monteiro
AU  - Ferreira MJ
FAU - Pessoa, Vanira Matos
AU  - Pessoa VM
FAU - Teixeira, Ana Claudia de Araujo
AU  - Teixeira AC
FAU - da Silva, Maria de Lourdes Vicente
AU  - da Silva Mde L
FAU - Braga, Lara de Queiroz Viana
AU  - Braga Lde Q
FAU - Teixeira, Maiana Maia
AU  - Teixeira MM
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - O verde da economia no campo: desafios a pesquisa e as politicas publicas para a 
      promocao da saude no avanco da modernizacao agricola.
PL  - Brazil
TA  - Cien Saude Colet
JT  - Ciencia & saude coletiva
JID - 9713483
SB  - IM
MH  - Agriculture/*standards
MH  - Brazil
MH  - *Economics
MH  - *Environmental Health
MH  - *Health Policy
MH  - Humans
MH  - Public Health
MH  - Research
MH  - Rural Health
MH  - Social Change
EDAT- 2012/06/16 06:00
MHDA- 2012/10/31 06:00
CRDT- 2012/06/16 06:00
PHST- 2012/04/11 00:00 [received]
PHST- 2012/05/02 00:00 [accepted]
PHST- 2012/06/16 06:00 [entrez]
PHST- 2012/06/16 06:00 [pubmed]
PHST- 2012/10/31 06:00 [medline]
AID - S1413-81232012000600017 [pii]
AID - 10.1590/s1413-81232012000600017 [doi]
PST - ppublish
SO  - Cien Saude Colet. 2012 Jun;17(6):1533-42. doi: 10.1590/s1413-81232012000600017.


PMID- 22699147
OWN - NLM
STAT- MEDLINE
DCOM- 20121025
LR  - 20181201
IS  - 1878-6464 (Electronic)
IS  - 0957-4271 (Linking)
VI  - 22
IP  - 1
DP  - 2012
TI  - Ethical, anatomical and physiological issues in developing vestibular implants
      for human use.
PG  - 3-9
LID - 10.3233/VES-2012-0446 [doi]
AB  - Effort towards the development of a vestibular implant for human use are being
      made. This paper will summarize the first important steps conducted in Geneva
      towards this ambitious goal. Basically, we have faced three major issues. First, 
      an ethical issue. While it was clear that such development would require the
      collaboration of human volunteers, it was also clear that stimulation of the
      vestibular system may produce periods of significant incomfort. We know today how
      to minimize (and potentially eliminate) this type of incomfort. The second issue 
      was anatomical. The anatomical topology of the vestibular system is complex, and 
      of potentially dangerous access (i.e. facial nerve damage). We choose not to
      place the electrodes inside the ampullae but close the vestibular nerve branches,
      to avoid any opening of the inner ear and limit the risk of hearing loss. Work on
      cadaver heads, confirmed by acute stimulations trials on patients undergoing ear 
      surgery under local anesthesia, demonstrated that it is possible to stimulate
      selectively both the posterior and lateral ampullary nerves, and elicit the
      expected vertical and horizontal nystagmic responses. The third issue was
      physiological. One of the goal of a vestibular implant will be to produce smooth 
      eye movements to stabilize gaze direction when the head is moving. Indeed, after 
      restoring a baseline or "rest" activity in the vestibular pathways with
      steady-state electrical stimulation, we demonstrated that modulation of this
      stimulation is producing smooth eye movements. In conclusion, humans can adapt to
      electrical stimulation of the vestibular system without too much discomfort.
      Surgical access to the posterior and lateral ampullary nerves have been developed
      and, electrical stimulation of the vestibular system can be used to artificially 
      elicit smooth eye movements of different speeds and directions, once the system
      is in adapted state. Therefore, the major prerequisites to develop a prototype
      vestibular implant for human use are fulfilled.
FAU - Guyot, Jean-Philippe
AU  - Guyot JP
AD  - Department of Clinical Neurosciences University Hospital, Faculty of Medicine,
      University of Geneva, Switzerland. jean-philippe.guyot@hcuge.ch
FAU - Gay, Annietta
AU  - Gay A
FAU - Kos, Maria Izabel
AU  - Kos MI
FAU - Pelizzone, Marco
AU  - Pelizzone M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - J Vestib Res
JT  - Journal of vestibular research : equilibrium & orientation
JID - 9104163
SB  - IM
MH  - Animals
MH  - Evoked Potentials, Auditory/physiology
MH  - Humans
MH  - Implants, Experimental/ethics/statistics & numerical data
MH  - Prostheses and Implants/*ethics/*statistics & numerical data
MH  - Therapeutic Human Experimentation/ethics
MH  - Vestibular Diseases/pathology/physiopathology/*therapy
MH  - Vestibule, Labyrinth/*anatomy & histology/pathology/*physiology
EDAT- 2012/06/16 06:00
MHDA- 2012/10/26 06:00
CRDT- 2012/06/16 06:00
PHST- 2012/06/16 06:00 [entrez]
PHST- 2012/06/16 06:00 [pubmed]
PHST- 2012/10/26 06:00 [medline]
AID - F3804U2186P61671 [pii]
AID - 10.3233/VES-2012-0446 [doi]
PST - ppublish
SO  - J Vestib Res. 2012;22(1):3-9. doi: 10.3233/VES-2012-0446.


PMID- 22699019
OWN - NLM
STAT- MEDLINE
DCOM- 20121214
LR  - 20130228
IS  - 1097-6760 (Electronic)
IS  - 0196-0644 (Linking)
VI  - 60
IP  - 4
DP  - 2012 Oct
TI  - Treatment of potential organ donors in the emergency department: a review.
PG  - 485-91
LID - 10.1016/j.annemergmed.2012.04.018 [doi]
LID - S0196-0644(12)00403-9 [pii]
AB  - The expanding role of emergency medicine in the care of potential organ donors
      presents unique ethical challenges. This article introduces emergency providers
      to the ethical challenges of organ donation, including issues of patient autonomy
      and consent, public perception and trust, goals of care, and the determination of
      death.
CI  - Copyright (c) 2012. Published by Mosby, Inc.
FAU - Michael, Glen E
AU  - Michael GE
AD  - University of Virginia, Charlottesville, VA, USA. glen@virginia.edu
FAU - Jesus, John E
AU  - Jesus JE
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120613
PL  - United States
TA  - Ann Emerg Med
JT  - Annals of emergency medicine
JID - 8002646
SB  - IM
CIN - Ann Emerg Med. 2012 Oct;60(4):492-4. PMID: 22699017
CIN - Ann Emerg Med. 2013 Feb;61(2):255-6. PMID: 23331654
CIN - Ann Emerg Med. 2013 Feb;61(2):256-7. PMID: 23331655
MH  - Death
MH  - Emergency Service, Hospital/*ethics
MH  - Family
MH  - Humans
MH  - Informed Consent/ethics
MH  - Patient Care Planning/ethics
MH  - Personal Autonomy
MH  - Tissue Donors/*ethics
MH  - Tissue and Organ Procurement/ethics
MH  - Trust
EDAT- 2012/06/16 06:00
MHDA- 2012/12/15 06:00
CRDT- 2012/06/16 06:00
PHST- 2011/10/11 00:00 [received]
PHST- 2012/04/07 00:00 [revised]
PHST- 2012/04/16 00:00 [accepted]
PHST- 2012/06/16 06:00 [entrez]
PHST- 2012/06/16 06:00 [pubmed]
PHST- 2012/12/15 06:00 [medline]
AID - S0196-0644(12)00403-9 [pii]
AID - 10.1016/j.annemergmed.2012.04.018 [doi]
PST - ppublish
SO  - Ann Emerg Med. 2012 Oct;60(4):485-91. doi: 10.1016/j.annemergmed.2012.04.018.
      Epub 2012 Jun 13.


PMID- 22698512
OWN - NLM
STAT- MEDLINE
DCOM- 20121128
LR  - 20220408
IS  - 1879-291X (Electronic)
IS  - 0301-5629 (Linking)
VI  - 38
IP  - 8
DP  - 2012 Aug
TI  - Ultrasonographic analysis versus histopathologic evaluation of carotid advanced
      atherosclerotic stenosis in an experimental rabbit model.
PG  - 1391-403
LID - 10.1016/j.ultrasmedbio.2012.03.008 [doi]
AB  - Advanced carotid atherosclerosis with severe stenosis (>70%) is a major clinical 
      risk factor for ischemic stroke. Our ability to test new protocols for the
      treatment of atherosclerotic stenosis in humans is limited for obvious ethical
      reasons; therefore, a suitable animal model is required. The aim of this study
      was to generate an easily reproducible and inexpensive experimental rabbit
      carotid model of advanced atherosclerosis with morphological similarities to the 
      human disease and the subsequent assessment of the reliability of B-mode
      ultrasound technology in the study of lumen area stenosis in this model. Briefly,
      New Zealand white rabbits underwent primary perivascular cold injury at the right
      common carotid artery followed by a 1.5% cholesterol-rich diet injury for eight
      weeks. All of the rabbits' arteries were imaged by B-mode ultrasound weekly,
      after which the rabbits were sacrificed, and their vessels were processed for
      histopathology. Ultrasound longitudinal view images from three cardiac cycles
      were processed by a new computerized analyzing method based on dynamic
      programming and maximum gradient algorithm for measurement of instantaneous
      changes in arterial wall thickness and lumen diameter in sequential ultrasound
      images. Histopathology results showed progressive changes, from the lipid-laden
      cells and fibrous connective tissue proliferation in neointimal layer, up to the 
      fibro-lipid plaque formation, resulting in vessel wall thickening, remodeling and
      lumen stenosis. The B-mode ultrasound images and the histologic measurements
      showed an increase in the mean wall thickness and the lumen area stenosis within 
      eight weeks. Quantitative and morphometric analysis of the mean wall thickness
      and the lumen area stenosis percentage showed a significant correlation between
      the B-mode ultrasound and the histological measurements at each time point (R =
      0.989 and R = 0.995, p < 0.05, respectively). In conclusion, we successfully
      produced advanced atherosclerosis in the rabbit carotid artery that is similar to
      the condition seen in patients. This condition in rabbits can be properly
      assessed by B-mode ultrasound image processing.
CI  - Copyright (c) 2012 World Federation for Ultrasound in Medicine & Biology.
      Published by Elsevier Inc. All rights reserved.
FAU - Mehrad, Hossein
AU  - Mehrad H
AD  - Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares
      University, Tehran, Iran.
FAU - Mokhtari-Dizaji, Manijhe
AU  - Mokhtari-Dizaji M
FAU - Ghanaati, Hossein
AU  - Ghanaati H
FAU - Shahbazfar, Amir-Ali
AU  - Shahbazfar AA
FAU - Salehnia, Mojdeh
AU  - Salehnia M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120612
PL  - England
TA  - Ultrasound Med Biol
JT  - Ultrasound in medicine & biology
JID - 0410553
SB  - IM
MH  - Animals
MH  - Carotid Stenosis/*diagnostic imaging/*pathology
MH  - *Disease Models, Animal
MH  - Humans
MH  - Male
MH  - Rabbits
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Ultrasonography
EDAT- 2012/06/16 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/06/16 06:00
PHST- 2011/06/24 00:00 [received]
PHST- 2012/03/06 00:00 [revised]
PHST- 2012/03/08 00:00 [accepted]
PHST- 2012/06/16 06:00 [entrez]
PHST- 2012/06/16 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - S0301-5629(12)00156-1 [pii]
AID - 10.1016/j.ultrasmedbio.2012.03.008 [doi]
PST - ppublish
SO  - Ultrasound Med Biol. 2012 Aug;38(8):1391-403. doi:
      10.1016/j.ultrasmedbio.2012.03.008. Epub 2012 Jun 12.


PMID- 22698492
OWN - NLM
STAT- MEDLINE
DCOM- 20120820
LR  - 20191210
IS  - 1558-3597 (Electronic)
IS  - 0735-1097 (Linking)
VI  - 59
IP  - 25
DP  - 2012 Jun 19
TI  - Cardiac surgeon report cards, referral for cardiac surgery, and the ethical
      responsibilities of cardiologists.
PG  - 2378-82
LID - 10.1016/j.jacc.2011.11.072 [doi]
AB  - Public reporting of clinical outcomes data is but one response to calls for
      increasing transparency in health care. Cardiac surgical operations are among the
      most commonly performed complex operative procedures. Risk-adjusted cardiac
      surgery mortality rate data for individual cardiac surgeons are currently
      available for >25% of the U.S. population as well as for Great Britain and
      Ireland. Although cardiologists are the primary source of referral of patients
      for cardiac surgery, surveys of cardiologists and analysis of market share data
      indicate this information is not being used to refer to cardiac surgeons with the
      lowest mortality rates. We review the ethical principles that should obligate
      cardiologists to discuss and use outcomes data, when available, in selecting
      cardiac surgeons to whom they refer their patients.
CI  - Copyright (c) 2012 American College of Cardiology Foundation. Published by
      Elsevier Inc. All rights reserved.
FAU - Brown, David L
AU  - Brown DL
AD  - Department of Medicine, Stony Brook University, New York, USA.
      david.brown@sbumed.org
FAU - Clarke, Stephen
AU  - Clarke S
FAU - Oakley, Justin
AU  - Oakley J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Coll Cardiol
JT  - Journal of the American College of Cardiology
JID - 8301365
SB  - IM
CIN - J Am Coll Cardiol. 2012 Jun 19;59(25):2383-6. PMID: 22698493
MH  - *Access to Information
MH  - *Cardiac Surgical Procedures/mortality/standards
MH  - Conflict of Interest
MH  - Ethics, Medical
MH  - Hospital Mortality
MH  - Humans
MH  - *Moral Obligations
MH  - *Outcome Assessment, Health Care
MH  - Physicians/*ethics
MH  - Quality of Health Care
MH  - Referral and Consultation/*ethics
MH  - Social Responsibility
EDAT- 2012/06/16 06:00
MHDA- 2012/08/21 06:00
CRDT- 2012/06/16 06:00
PHST- 2011/09/09 00:00 [received]
PHST- 2011/11/08 00:00 [revised]
PHST- 2011/11/25 00:00 [accepted]
PHST- 2012/06/16 06:00 [entrez]
PHST- 2012/06/16 06:00 [pubmed]
PHST- 2012/08/21 06:00 [medline]
AID - S0735-1097(12)01215-6 [pii]
AID - 10.1016/j.jacc.2011.11.072 [doi]
PST - ppublish
SO  - J Am Coll Cardiol. 2012 Jun 19;59(25):2378-82. doi: 10.1016/j.jacc.2011.11.072.


PMID- 22698051
OWN - NLM
STAT- MEDLINE
DCOM- 20121012
LR  - 20211021
IS  - 1541-0048 (Electronic)
IS  - 0090-0036 (Linking)
VI  - 102
IP  - 8
DP  - 2012 Aug
TI  - Beyond bioethics: reckoning with the public health paradigm.
PG  - 1447-50
LID - 10.2105/AJPH.2012.300661 [doi]
AB  - In the wake of scandal over troubling research abuses, the 1970s witnessed the
      birth of a new system of ethical oversight. The bioethics framework, with its
      emphasis on autonomy, assumed a commanding role in debates regarding how to weigh
      the needs of society against the rights of individuals. Yet the history of
      resistance to oversight underscores that some domains of science hewed to a
      different paradigm of accountability--one that elevated the common good over
      individual rights. Federal officials have now proposed to dramatically limit the 
      reach of ethical oversight. The Institute of Medicine has called for a rollback
      of the federal privacy rule. The changing emphasis makes it imperative to grapple
      with the history of the public interest paradigm.
FAU - Fairchild, Amy L
AU  - Fairchild AL
AD  - Center for the History and Ethics of Public Health, Department of Sociomedical
      Sciences, Mailman School of Public Health, Columbia University, New York, NY
      10032, USA. alf4@columbia.edu
FAU - Johns, David Merritt
AU  - Johns DM
LA  - eng
PT  - Historical Article
PT  - Journal Article
DEP - 20120614
PL  - United States
TA  - Am J Public Health
JT  - American journal of public health
JID - 1254074
SB  - IM
CIN - Am J Public Health. 2012 Nov;102(11):e6. PMID: 22994279
MH  - *Bioethics
MH  - Biomedical Research/*ethics/legislation & jurisprudence
MH  - Ethical Review/legislation & jurisprudence/*standards
MH  - Government Regulation
MH  - Health Insurance Portability and Accountability Act
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Privacy
MH  - *Public Health
MH  - Social Responsibility
MH  - United States
MH  - United States Dept. of Health and Human Services
PMC - PMC3464836
EDAT- 2012/06/16 06:00
MHDA- 2012/10/13 06:00
CRDT- 2012/06/16 06:00
PHST- 2012/06/16 06:00 [entrez]
PHST- 2012/06/16 06:00 [pubmed]
PHST- 2012/10/13 06:00 [medline]
AID - 10.2105/AJPH.2012.300661 [doi]
PST - ppublish
SO  - Am J Public Health. 2012 Aug;102(8):1447-50. doi: 10.2105/AJPH.2012.300661. Epub 
      2012 Jun 14.


PMID- 22698030
OWN - NLM
STAT- MEDLINE
DCOM- 20121012
LR  - 20211021
IS  - 1541-0048 (Electronic)
IS  - 0090-0036 (Linking)
VI  - 102
IP  - 8
DP  - 2012 Aug
TI  - Minnesota Pandemic Ethics Project update.
PG  - e8; author reply e8-9
LID - 10.2105/AJPH.2012.300712 [doi]
FAU - Vawter, Dorothy E
AU  - Vawter DE
FAU - Garrett, J Eline
AU  - Garrett JE
LA  - eng
PT  - Letter
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Comment
DEP - 20120614
PL  - United States
TA  - Am J Public Health
JT  - American journal of public health
JID - 1254074
SB  - IM
CON - Am J Public Health. 2011 Nov;101(11):2080-2. PMID: 21940921
MH  - Disaster Planning/*organization & administration
MH  - *Ethics, Clinical
MH  - Humans
MH  - Influenza, Human/*epidemiology
MH  - *Public Health Administration
MH  - *State Government
PMC - PMC3464844
EDAT- 2012/06/16 06:00
MHDA- 2012/10/13 06:00
CRDT- 2012/06/16 06:00
PHST- 2012/06/16 06:00 [entrez]
PHST- 2012/06/16 06:00 [pubmed]
PHST- 2012/10/13 06:00 [medline]
AID - 10.2105/AJPH.2012.300712 [doi]
PST - ppublish
SO  - Am J Public Health. 2012 Aug;102(8):e8; author reply e8-9. doi:
      10.2105/AJPH.2012.300712. Epub 2012 Jun 14.


PMID- 22697334
OWN - NLM
STAT- MEDLINE
DCOM- 20121109
LR  - 20181201
IS  - 1754-9485 (Electronic)
IS  - 1754-9477 (Linking)
VI  - 56
IP  - 3
DP  - 2012 Jun
TI  - Floor of mouth carcinoma: surgery still the dominant mode of treatment.
PG  - 338-46
LID - 10.1111/j.1754-9485.2012.02387.x [doi]
AB  - INTRODUCTION: To evaluate the care and outcomes for patients presenting with
      floor of mouth (FOM) cancers. METHODS: In this Ethics-approved audit, all
      eligible patients were evaluated with eligibility defined as having a squamous
      cell carcinoma originating in the FOM. Patient, disease and treatment factors
      were defined. Primary end points were ultimate local/regional control and
      cancer-specific survival. These were analysed according to the Kaplan-Meier
      method. The log-rank test was used to determine statistical significance between 
      survival curves. Multivariate analysis was conducted using Cox regression.
      RESULTS: A total of 157 patients were eligible for analysis, 76% males and 24%
      females, with 38 (24%) having a prior diagnosis of cancer. Surgery was performed 
      in 126 patients (54 with pre/postoperative radiotherapy), radiotherapy only in 30
      patients and chemotherapy only in 1 patient. Surgery had the best local control
      (85%), with 23/30 (77%) patients having radiotherapy failing locally. Ultimate
      regional control was achieved in 89% of patients, while new primaries occurred in
      45 (29%) CONCLUSIONS: Surgery remains an essential component of the treatment of 
      patients with FOM cancers, with a high likelihood of other cancers developing.
CI  - (c) 2012 The Authors. Journal of Medical Imaging and Radiation Oncology (c) 2012 
      The Royal Australian and New Zealand College of Radiologists.
FAU - Smee, Robert I
AU  - Smee RI
AD  - Department of Radiation Oncology, the Prince of Wales Cancer Centre, Randwick,
      New South Wales, Australia.
FAU - Broadley, Kathryn
AU  - Broadley K
FAU - Bridger, G Patrick
AU  - Bridger GP
FAU - Williams, Janet
AU  - Williams J
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120525
PL  - Australia
TA  - J Med Imaging Radiat Oncol
JT  - Journal of medical imaging and radiation oncology
JID - 101469340
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mouth Neoplasms/*mortality/*surgery
MH  - Neoplasm Recurrence, Local/*mortality/*prevention & control
MH  - Neoplasms, Squamous Cell/*mortality/*therapy
MH  - New South Wales/epidemiology
MH  - Oral Surgical Procedures/*mortality/statistics & numerical data
MH  - Practice Patterns, Physicians'/statistics & numerical data
MH  - Prevalence
MH  - Risk Factors
MH  - Survival Analysis
MH  - Survival Rate
EDAT- 2012/06/16 06:00
MHDA- 2012/11/10 06:00
CRDT- 2012/06/16 06:00
PHST- 2012/06/16 06:00 [entrez]
PHST- 2012/06/16 06:00 [pubmed]
PHST- 2012/11/10 06:00 [medline]
AID - 10.1111/j.1754-9485.2012.02387.x [doi]
PST - ppublish
SO  - J Med Imaging Radiat Oncol. 2012 Jun;56(3):338-46. doi:
      10.1111/j.1754-9485.2012.02387.x. Epub 2012 May 25.


PMID- 22697226
OWN - NLM
STAT- MEDLINE
DCOM- 20120814
LR  - 20120615
IS  - 1751-486X (Electronic)
IS  - 1751-4851 (Linking)
VI  - 16
IP  - 3
DP  - 2012 Jun-Jul
TI  - An overview of surrogacy around the world: trends, questions and ethical issues.
PG  - 231-6
LID - 10.1111/j.1751-486X.2012.01734.x [doi]
AB  - Although the birth of a child is typically considered a very happy time for
      parents, surrogacy is often unchartered territory that can become very stressful 
      for all parties involved. Part of the stress stems from the fact that different
      states and countries have varying laws and regulations overseeing surrogacy. This
      article provides insight regarding surrogacy around the world, including
      professional, societal and ethical issues.
CI  - (c) 2012 AWHONN.
FAU - Armour, Kim L
AU  - Armour KL
AD  - Obstetrics and Gynecology at Northwestern Memorial Physicians Group, Chicago, IL,
      USA. karmour3@gmail.com
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Nurs Womens Health
JT  - Nursing for women's health
JID - 101304602
MH  - Coercion
MH  - Commerce
MH  - *Ethics
MH  - Fees and Charges
MH  - Female
MH  - Humans
MH  - *Internationality
MH  - Pregnancy
MH  - Public Policy
MH  - Socioeconomic Factors
MH  - Surrogate Mothers/*legislation & jurisprudence/*psychology/statistics & numerical
      data
EDAT- 2012/06/16 06:00
MHDA- 2012/08/15 06:00
CRDT- 2012/06/16 06:00
PHST- 2012/06/16 06:00 [entrez]
PHST- 2012/06/16 06:00 [pubmed]
PHST- 2012/08/15 06:00 [medline]
AID - 10.1111/j.1751-486X.2012.01734.x [doi]
AID - S1751-4851(15)30672-3 [pii]
PST - ppublish
SO  - Nurs Womens Health. 2012 Jun-Jul;16(3):231-6. doi:
      10.1111/j.1751-486X.2012.01734.x.


PMID- 22697190
OWN - NLM
STAT- MEDLINE
DCOM- 20120829
LR  - 20220311
IS  - 1555-2101 (Electronic)
IS  - 0160-6689 (Linking)
VI  - 73
IP  - 5
DP  - 2012 May
TI  - Managing psychiatric issues in elite athletes.
PG  - 640-4
LID - 10.4088/JCP.11r07381 [doi]
AB  - OBJECTIVE: Providing psychiatric consultation to elite athletes presents unique
      and complex issues. These patients present with multifaceted medical,
      psychological, and performance concerns. We provide the first report of
      professional and ethical quandaries that arise in treating elite athletes and
      ways to address them. METHOD: We identified studies through a MEDLINE search.
      Search terms included the following, individually and in combination: psychiatry,
      athletes, elite athletes, professional athletes, sports, sport psychiatry, mental
      illness, major depressive disorder, depression, bipolar disorder, suicide,
      anxiety, generalized anxiety disorder, obsessive compulsive disorder, social
      phobia, social anxiety disorder, panic disorder, post traumatic stress disorder, 
      specific phobia, psychosis, eating disorders, anorexia nervosa, bulimia nervosa, 
      attention deficit hyperactivity disorder, substance abuse, substance dependence, 
      addiction, alcohol, anabolic steroids, stimulants, antidepressants, mood
      stabilizers, anxiolytics, antipsychotics, sedative-hypnotics, psychotropics,
      medications, and psychiatric medications. We restricted results to the English
      language and used no date restrictions. We retrieved all articles discussing
      psychiatric diagnosis or psychiatric treatment of athletes. We reviewed each
      article's findings to see if they applied to elite athletes and reviewed the
      references of each article for additional articles that had been missed in the
      initial search and that might include findings relevant to the scope of our
      article. Our search found no controlled data to guide treatment in working with
      elite athletes. We describe the literature that does exist and present 4 case
      examples to illustrate diagnostic and treatment issues with elite athletes.
      RESULTS: Patient and family characteristics are described as they bear on
      treatment context. The key pitfalls that interfere with treatment are listed, and
      clinical guidelines to improve outcomes are suggested. Specific key pitfalls that
      interfere with treatment include elite athletes' expecting "special treatment,"
      issues of flexibility in treatment to accommodate travel schedules and the need
      for privacy, and inclusion of coaches and significant others in treatment.
      Recommendations for working with this population include being flexible within
      reason about timing of sessions, involving family members when relationship
      issues are involved, and not compromising on delivering the appropriate
      treatment, including medications and hospitalizations as necessary. CONCLUSIONS: 
      The challenges of treating the elite athlete are great, but successful treatment 
      is possible.
CI  - (c) Copyright 2012 Physicians Postgraduate Press, Inc.
FAU - Glick, Ira D
AU  - Glick ID
AD  - Department of Psychiatry and Behavioral Sciences, Stanford University School of
      Medicine, Stanford, California, USA. iraglick@stanford.edu
FAU - Stillman, Mark A
AU  - Stillman MA
FAU - Reardon, Claudia L
AU  - Reardon CL
FAU - Ritvo, Eva C
AU  - Ritvo EC
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Psychiatry
JT  - The Journal of clinical psychiatry
JID - 7801243
SB  - IM
MH  - Adult
MH  - Appointments and Schedules
MH  - Athletes/*psychology
MH  - Female
MH  - Humans
MH  - Male
MH  - Mental Disorders/drug therapy/psychology/*therapy
MH  - Patient Compliance
MH  - *Physician-Patient Relations
MH  - Social Stigma
MH  - United States
EDAT- 2012/06/16 06:00
MHDA- 2012/08/30 06:00
CRDT- 2012/06/16 06:00
PHST- 2011/09/08 00:00 [received]
PHST- 2011/10/31 00:00 [accepted]
PHST- 2012/06/16 06:00 [entrez]
PHST- 2012/06/16 06:00 [pubmed]
PHST- 2012/08/30 06:00 [medline]
AID - 10.4088/JCP.11r07381 [doi]
PST - ppublish
SO  - J Clin Psychiatry. 2012 May;73(5):640-4. doi: 10.4088/JCP.11r07381.


PMID- 22696840
OWN - NLM
STAT- MEDLINE
DCOM- 20120814
LR  - 20120615
IS  - 8756-8160 (Print)
IS  - 8756-8160 (Linking)
VI  - 27
IP  - 3
DP  - 2012 Spring
TI  - Other people's lives: reflections on medicine, ethics, and euthanasia. Part two: 
      Medicine versus euthanasia. XXVII. Death in gray zone. XXXVII. American assisted 
      suicide.
PG  - 231-53
FAU - Fenigsen, Richard
AU  - Fenigsen R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Issues Law Med
JT  - Issues in law & medicine
JID - 8511295
SB  - IM
MH  - Attitude of Health Personnel
MH  - Euthanasia, Active/*ethics/legislation & jurisprudence
MH  - Humans
MH  - Withholding Treatment/ethics/legislation & jurisprudence
EDAT- 2012/06/16 06:00
MHDA- 2012/08/15 06:00
CRDT- 2012/06/16 06:00
PHST- 2012/06/16 06:00 [entrez]
PHST- 2012/06/16 06:00 [pubmed]
PHST- 2012/08/15 06:00 [medline]
PST - ppublish
SO  - Issues Law Med. 2012 Spring;27(3):231-53.


PMID- 22696577
OWN - NLM
STAT- MEDLINE
DCOM- 20121016
LR  - 20211021
IS  - 1522-1490 (Electronic)
IS  - 0363-6119 (Linking)
VI  - 303
IP  - 3
DP  - 2012 Aug 1
TI  - Potential clinical translation of juvenile rodent inactivity models to study the 
      onset of childhood obesity.
PG  - R247-58
LID - 10.1152/ajpregu.00167.2012 [doi]
AB  - According to the latest data from the Center for Disease Control and Prevention
      17%, or 12.5 million, of children and adolescents aged 2-19 years in the United
      States are obese. Physical inactivity is designated as one of the actual causes
      of US deaths and undoubtedly contributes to the obesity epidemic in children and 
      adults. Examining the effects of inactivity on physiological homeostasis during
      youth is crucial given that 58% of children between the ages 6-11 yr old fail to 
      obtain the recommended 60 min/day of physical activity and 92% of adolescents
      fail to achieve this goal [Troiano et al. Med Sci Sports Exerc. 40, 2008].
      Nonetheless, invasive mechanistic studies in children linking diminished physical
      activity with metabolic maladies are lacking for obvious ethical reasons. The
      rodent wheel lock (WL) model was adopted by our laboratory and others to study
      how different organ systems of juvenile rats respond to a cessation of daily
      physical activity. Our WL model houses rats in cages equipped with voluntary
      running wheels starting at 28 days of age. After a certain period of voluntary
      running (3 to 6 wk), the wheels are locked, thus preventing the rats' primary
      source of physical activity. The studies discussed herein suggest that
      obesity-associated maladies including skeletal muscle insulin resistance,
      hypothalamic leptin resistance, fatty acid oxidation impairments in skeletal
      muscle and adipose tissue, nonalcoholic fatty liver disease, and endothelial
      dysfunction are initiated in juvenile animals that are restrained from voluntary 
      exercise via WL. The use of the juvenile rodent WL or other inactivity models
      will continue to provide a powerful clinical translational tool that can be used 
      for primordial prevention of human childhood obesity.
FAU - Roberts, Michael D
AU  - Roberts MD
AD  - Department of Biomedical Sciences, College of Veterinary Medicine, University of 
      Missouri, Columbia, 65211, USA.
FAU - Company, Joseph M
AU  - Company JM
FAU - Brown, Jacob D
AU  - Brown JD
FAU - Toedebusch, Ryan G
AU  - Toedebusch RG
FAU - Padilla, Jaume
AU  - Padilla J
FAU - Jenkins, Nathan T
AU  - Jenkins NT
FAU - Laughlin, M Harold
AU  - Laughlin MH
FAU - Booth, Frank W
AU  - Booth FW
LA  - eng
GR  - R01HL-036088/HL/NHLBI NIH HHS/United States
GR  - T32AR-048523/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120613
PL  - United States
TA  - Am J Physiol Regul Integr Comp Physiol
JT  - American journal of physiology. Regulatory, integrative and comparative
      physiology
JID - 100901230
SB  - IM
MH  - Animals
MH  - Child
MH  - *Disease Models, Animal
MH  - Homeostasis/physiology
MH  - Humans
MH  - Obesity/*epidemiology/prevention & control
MH  - Physical Conditioning, Animal/*physiology
MH  - Rats
MH  - Reproducibility of Results
MH  - Risk Factors
MH  - *Sedentary Behavior
PMC - PMC3423989
EDAT- 2012/06/15 06:00
MHDA- 2012/10/17 06:00
CRDT- 2012/06/15 06:00
PHST- 2012/06/15 06:00 [entrez]
PHST- 2012/06/15 06:00 [pubmed]
PHST- 2012/10/17 06:00 [medline]
AID - ajpregu.00167.2012 [pii]
AID - 10.1152/ajpregu.00167.2012 [doi]
PST - ppublish
SO  - Am J Physiol Regul Integr Comp Physiol. 2012 Aug 1;303(3):R247-58. doi:
      10.1152/ajpregu.00167.2012. Epub 2012 Jun 13.


PMID- 22696359
OWN - NLM
STAT- MEDLINE
DCOM- 20120813
LR  - 20211021
IS  - 1469-493X (Electronic)
IS  - 1361-6137 (Linking)
IP  - 6
DP  - 2012 Jun 13
TI  - Surgery for cataracts in people with age-related macular degeneration.
PG  - CD006757
LID - 10.1002/14651858.CD006757.pub3 [doi]
AB  - BACKGROUND: Cataract and age-related macular degeneration (AMD) are common causes
      of decreased vision that often occur simultaneously in people over age 50.
      Although cataract surgery is an effective treatment for cataract-induced visual
      loss, some clinicians suspect that such an intervention may increase the risk of 
      worsening of underlying AMD and thus have deleterious effects on vision.
      OBJECTIVES: The objective of this review was to evaluate the effectiveness and
      safety of cataract surgery in eyes with AMD. SEARCH METHODS: We searched CENTRAL 
      (which contains the Cochrane Eyes and Vision Group Trials Register) (The Cochrane
      Library 2012, Issue 4), MEDLINE (January 1950 to April 2012), EMBASE (January
      1980 to April 2012), Latin American and Caribbean Literature on Health Sciences
      (LILACS) (January 1982 to April 2012), the metaRegister of Controlled Trials
      (mRCT) (www.controlled-trials.com), ClinicalTrials.gov (www.clinicaltrials.gov)
      and the WHO International Clinical Trials Registry Platform (ICTRP)
      (www.who.int/ictrp/search/en). There were no date or language restrictions in the
      electronic searches for trials. The electronic databases were last searched on 16
      April 2012. SELECTION CRITERIA: We included randomized controlled trials (RCTs)
      and quasi-randomized trials of eyes affected by both cataract and AMD in which
      cataract surgery would be compared to no surgery. DATA COLLECTION AND ANALYSIS:
      Two authors independently evaluated the search results against the inclusion and 
      exclusion criteria. Two authors independently extracted data and assessed risk of
      bias for included studies. We resolved discrepancies by discussion. MAIN RESULTS:
      One RCT with 60 participants with visually significant cataract and AMD was
      included in this review. Participants were randomized to immediate cataract
      surgery (within two weeks of enrollment) (n = 29) or delayed cataract surgery
      (six months after enrollment) (n = 31). At six months, four participants were
      lost to follow-up; two participants from each group. The immediate surgery group 
      showed mean improvement in best-corrected visual acuity (BCVA) compared with the 
      delayed surgery group at six months (mean difference (MD) 0.15 LogMAR, 95%
      confidence interval (CI) 0.28 to 0.02). There was no significant difference in
      the development of choroidal neovascularization between groups (1/27 eyes in the 
      immediate surgery group versus 0/29 eyes in the delayed surgery group). Results
      from Impact of Vision Impairment (IVI) questionnaires suggested that the
      immediate surgery group faired better with quality of life outcomes than the
      delayed surgery group (MD in IVI logit scores 1.60, 95% CI 0.61 to 2.59). No
      postoperative complication was reported. We identified a second potentially
      relevant study of immediate versus delayed cataract surgery in 54 people with
      AMD. Results for the study are not yet available, but may be eligible for future 
      updates of this review. AUTHORS' CONCLUSIONS: At this time, it is not possible to
      draw reliable conclusions from the available data to determine whether cataract
      surgery is beneficial or harmful in people with AMD. Physicians will have to make
      practice decisions based on best clinical judgment until controlled trials are
      conducted and their findings published.It would be valuable for future research
      to investigate prospective RCTs comparing cataract surgery to no surgery in
      patients with AMD to better evaluate whether cataract surgery is beneficial or
      harmful in this group. However ethical considerations need to be addressed when
      delaying a potentially beneficial treatment and it may not be feasible to conduct
      a long-term study where surgery is withheld from the control group. Utilization
      of pre-existing, standardized systems for grading cataract and AMD and measuring 
      outcomes (visual acuity, change in visual acuity, worsening of AMD and quality of
      life measures) should be encouraged.
FAU - Casparis, Heather
AU  - Casparis H
AD  - Unite de Chirurgie Vitreoretinienne, Jules Gonin EyeHospital, CH-1004 Lausanne,
      Switzerland. Heather.BartlettCasparis@fa2.ch.
FAU - Lindsley, Kristina
AU  - Lindsley K
FAU - Kuo, Irene C
AU  - Kuo IC
FAU - Sikder, Shameema
AU  - Sikder S
FAU - Bressler, Neil B
AU  - Bressler NB
LA  - eng
GR  - N01 EY21003/EY/NEI NIH HHS/United States
GR  - U01 EY020522/EY/NEI NIH HHS/United States
GR  - 1 U01 EY020522-01/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20120613
PL  - England
TA  - Cochrane Database Syst Rev
JT  - The Cochrane database of systematic reviews
JID - 100909747
SB  - IM
UIN - Cochrane Database Syst Rev. 2017 Feb 16;2:CD006757. PMID: 28206671
UOF - Cochrane Database Syst Rev. 2009;(1):CD006757. PMID: 19160299
MH  - Cataract/*complications
MH  - Cataract Extraction/*adverse effects
MH  - Disease Progression
MH  - Humans
MH  - Macular Degeneration/*complications/pathology
MH  - Middle Aged
MH  - Randomized Controlled Trials as Topic
PMC - PMC3480178
MID - NIHMS396510
EDAT- 2012/06/15 06:00
MHDA- 2012/08/14 06:00
CRDT- 2012/06/15 06:00
PHST- 2012/06/15 06:00 [entrez]
PHST- 2012/06/15 06:00 [pubmed]
PHST- 2012/08/14 06:00 [medline]
AID - 10.1002/14651858.CD006757.pub3 [doi]
PST - epublish
SO  - Cochrane Database Syst Rev. 2012 Jun 13;(6):CD006757. doi:
      10.1002/14651858.CD006757.pub3.


PMID- 22696094
OWN - NLM
STAT- MEDLINE
DCOM- 20131209
LR  - 20211021
IS  - 0973-7693 (Electronic)
IS  - 0019-5456 (Linking)
VI  - 79
IP  - 10
DP  - 2012 Oct
TI  - Environmental risk factors for persistent asthma in Lucknow.
PG  - 1311-7
LID - 10.1007/s12098-012-0817-6 [doi]
AB  - OBJECTIVE: To identify the risk factors for persistent asthma among common
      environmental exposures, like ambient air pollutants and second hand smoke,
      animals, place of residence, decreased ventilation, dust, as well as history of
      allergic conditions like rhinitis, dermatitis and family history of asthma in
      children. METHODS: This hospital-based, cross-sectional study was conducted after
      institutional ethical clearance. Children aged 1-12 y with asthma were recruited 
      after parental consent. Children were classified into asthma severity categories 
      according to GINA 2002 and level of control categories according to GINA 2009
      guidelines. Adjusted logistic regression analysis was used to identify factors
      associated with persistent asthma. RESULTS: From August 2008 through October
      2010, 205 asthmatic children were recruited of which 73 (35.60 %) had
      intermittent and 132 (64.40 %) had persistent asthma. Asthma was controlled in 19
      (9.26 %), partly controlled in 90 (43.90 %) and uncontrolled in 96 (46.82 %).
      Patients with persistent asthma were more likely to have uncontrolled asthma (OR 
      = 8.28; 95 % CI: 2.43-31.01; p < 0.001). Adjusting for age, sex, socioeconomic
      status and place of residence, persistent asthma was associated with residence
      within 1.5 km from heavy traffic (OR = 4.58; 95%CI: 2.18-9.59; p < 0.001) and
      father smoking indoors >5 cigarettes or "bidi"/day (OR = 17.76; 95 % CI:
      1.85-170.76; p = 0.01). CONCLUSIONS: Since patients with persistent asthma are
      more likely to have uncontrolled asthma and since persistent asthma is associated
      with residence closer to heavy traffic and exposure to second hand smoke,
      minimizing exposures to these may help in better asthma control.
FAU - Awasthi, Shally
AU  - Awasthi S
AD  - Department of Pediatrics, Chhatrapati Shahuji Maharaj Medical University (CSMMU),
      Lucknow, 226003 Uttar Pradesh, India. shallya@rediffmail.com
FAU - Gupta, Sarika
AU  - Gupta S
FAU - Maurya, Nutan
AU  - Maurya N
FAU - Tripathi, Priya
AU  - Tripathi P
FAU - Dixit, Pratibha
AU  - Dixit P
FAU - Sharma, Neeraj
AU  - Sharma N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120614
PL  - India
TA  - Indian J Pediatr
JT  - Indian journal of pediatrics
JID - 0417442
SB  - IM
MH  - Asthma/*epidemiology
MH  - Child
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Environmental Exposure/*adverse effects
MH  - Female
MH  - Humans
MH  - India/epidemiology
MH  - Infant
MH  - Logistic Models
MH  - Male
MH  - Risk Assessment
MH  - Risk Factors
EDAT- 2012/06/15 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/06/15 06:00
PHST- 2011/08/18 00:00 [received]
PHST- 2012/05/25 00:00 [accepted]
PHST- 2012/06/15 06:00 [entrez]
PHST- 2012/06/15 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1007/s12098-012-0817-6 [doi]
PST - ppublish
SO  - Indian J Pediatr. 2012 Oct;79(10):1311-7. doi: 10.1007/s12098-012-0817-6. Epub
      2012 Jun 14.


PMID- 22695977
OWN - NLM
STAT- MEDLINE
DCOM- 20130131
LR  - 20211203
IS  - 1433-0563 (Electronic)
IS  - 0340-2592 (Linking)
VI  - 51
IP  - 9
DP  - 2012 Sep
TI  - [Trial registration for the improvement of transparency in scientific research.
      The German Association of Urology now enables registration in the register
      network of the WHO].
PG  - 1278-81
LID - 10.1007/s00120-012-2914-6 [doi]
AB  - Transparency is essential for the efficient transfer of scientific knowledge from
      research into practice but is often impaired by non-publication of whole studies 
      or by inappropriate publication of trial results. Prospective trial registration 
      has the potential to increase transparency in scientific research because it
      allows the evaluation of trial methodology and the appraisal of potential
      publication bias. Trial registration is a scientific, ethical and moral
      obligation which needs self-commitment of researchers and sponsors to prospective
      trial registration. The urological trial register of the German Society of
      Urology is now affiliated with the German Register of Clinical Studies, a
      national primary register, which enables easy registration in the register
      network of the WHO.
FAU - Kunath, F
AU  - Kunath F
AD  - Klinik fur Urologie, Universitatsklinikum Erlangen, Krankenhausstrasse 12, 91054,
      Erlangen, Deutschland. frank.kunath@uk-erlangen.de
FAU - Becker, C
AU  - Becker C
FAU - Jena, S
AU  - Jena S
FAU - Meerpohl, J J
AU  - Meerpohl JJ
FAU - Antes, G
AU  - Antes G
FAU - Wullich, B
AU  - Wullich B
LA  - ger
PT  - Journal Article
TT  - Studienregistrierung zur Verbesserung der Transparenz in der klinischen
      Forschung. Die DGU ermoglicht jetzt eine einfache WHO-konforme Registrierung
      klinischer Studien.
PL  - Germany
TA  - Urologe A
JT  - Der Urologe. Ausg. A
JID - 1304110
SB  - IM
MH  - Germany
MH  - Periodicals as Topic/*standards
MH  - Registries/*standards
MH  - Societies, Medical/*organization & administration
MH  - Translational Research, Biomedical/*standards
MH  - World Health Organization/*organization & administration
EDAT- 2012/06/15 06:00
MHDA- 2013/02/01 06:00
CRDT- 2012/06/15 06:00
PHST- 2012/06/15 06:00 [entrez]
PHST- 2012/06/15 06:00 [pubmed]
PHST- 2013/02/01 06:00 [medline]
AID - 10.1007/s00120-012-2914-6 [doi]
PST - ppublish
SO  - Urologe A. 2012 Sep;51(9):1278-81. doi: 10.1007/s00120-012-2914-6.


PMID- 22695931
OWN - NLM
STAT- MEDLINE
DCOM- 20130319
LR  - 20120905
IS  - 1534-4681 (Electronic)
IS  - 1068-9265 (Linking)
VI  - 19
IP  - 9
DP  - 2012 Sep
TI  - Pharyngolaryngo-esophagectomy with laparoscopic gastric pull-up: a reappraisal
      for the pharyngoesophageal junction cancer.
PG  - 2980
LID - 10.1245/s10434-012-2375-6 [doi]
AB  - BACKGROUND: Surgical treatment of advanced hypopharyngeal tumors is still a
      surgical challenge. We report a case of a hypopharyngeal tumor treated with a
      pharyngolaryngo-esophagectomy (PLE) and laparoscopic gastric tubulization and
      interposition. METHODS: A 56-year-old man presented with a relapsing hypopharynx 
      carcinoma, after primary chemoradiation therapy. Preoperative workup showed a
      stage IV cancer with esophageal invasion and multiple cervical lymph node
      metastases. Surgical treatment consisted of a cervical phase, with larynx,
      pharynx, and esophagus dissection, radical lymph node dissection, homolateral
      hemithyroidectomy and definitive tracheostomy, and an abdominal phase with a
      4-trocar laparoscopy. The gastrocolic ligament was opened, and short gastric and 
      left gastric vessels were divided preserving an accessory left hepatic artery.
      Gastric tailoring was carried out with 45-mm linear staplers. The hiatus was
      opened and the esophagus dissected free with Ultracision (Ethicon Endo-Surgery,
      Cincinnati, OH) to the tracheal bifurcation. The upper esophagus was bluntly
      mobilized by finger and sponge stick dissection. The gastric tube was pulled up, 
      and the anastomosis between the stomach and the tongue base was performed with a 
      2-layer interrupted hand-sewn technique. RESULTS: Total operative time was 390
      min (abdominal time 180 min). Estimated blood loss was 400 cc. The number of
      dissected cervical lymph nodes was 32. Oral feeding was started after 10 days,
      and the patient was discharged after 14 days. Stage of disease was pT4N1M0 G3 R0.
      CONCLUSIONS: Laparoscopic surgery allows a minimally invasive gastric tailoring
      and tubulization and transhiatal esophageal dissection and represents a valuable 
      alternative for intestinal reconstruction after PLE. CT scan showing a large
      hypopharynx carcinoma involving cervical lymph nodes and cervical esophagus.
FAU - Huscher, Cristiano
AU  - Huscher C
AD  - Surgery, University of Molise, Isernia, Italy. c.huscher@tiscali.it
FAU - Mingoli, Andrea
AU  - Mingoli A
FAU - Mereu, Andrea
AU  - Mereu A
FAU - Sgarzini, Giovanna
AU  - Sgarzini G
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20120614
PL  - United States
TA  - Ann Surg Oncol
JT  - Annals of surgical oncology
JID - 9420840
SB  - IM
MH  - Carcinoma/*therapy
MH  - Esophagectomy/methods
MH  - Humans
MH  - Hypopharyngeal Neoplasms/*therapy
MH  - Laparoscopy
MH  - Laryngectomy/methods
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/*surgery
MH  - Pharyngectomy/methods
MH  - Stomach/surgery
EDAT- 2012/06/15 06:00
MHDA- 2013/03/21 06:00
CRDT- 2012/06/15 06:00
PHST- 2011/01/25 00:00 [received]
PHST- 2012/06/15 06:00 [entrez]
PHST- 2012/06/15 06:00 [pubmed]
PHST- 2013/03/21 06:00 [medline]
AID - 10.1245/s10434-012-2375-6 [doi]
PST - ppublish
SO  - Ann Surg Oncol. 2012 Sep;19(9):2980. doi: 10.1245/s10434-012-2375-6. Epub 2012
      Jun 14.


PMID- 22695704
OWN - NLM
STAT- MEDLINE
DCOM- 20130424
LR  - 20120911
IS  - 1878-0946 (Electronic)
IS  - 1744-165X (Linking)
VI  - 17
IP  - 5
DP  - 2012 Oct
TI  - Ethical dimensions of fetal neurology.
PG  - 252-5
LID - 10.1016/j.siny.2012.05.006 [doi]
AB  - Ethics is an essential dimension of the management of counseling a pregnant woman
      when a neurologic anomaly is diagnosed. This paper provides an overview of
      obstetric ethics, with a central focus on the ethical concept of the fetus as a
      patient. On this basis, the authors analyze the ethical and clinical dimensions
      of the obstetric management options for pregnancies complicated by a neurologic
      anomaly. These management options include aggressive management, induced
      abortion, termination of pregnancy during the third trimester, non-aggressive
      obstetric management, and cephalocentesis.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Chervenak, Frank A
AU  - Chervenak FA
AD  - New York Presbyterian Hospital-Weill Medical College of Cornell University, New
      York, NY 10065, USA. fac2001@med.cornell.edu
FAU - McCullough, Laurence B
AU  - McCullough LB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120612
PL  - Netherlands
TA  - Semin Fetal Neonatal Med
JT  - Seminars in fetal & neonatal medicine
JID - 101240003
SB  - IM
MH  - Female
MH  - Fetus
MH  - Humans
MH  - Nervous System Diseases/*diagnosis
MH  - Obstetrics/*ethics
MH  - Pregnancy
MH  - Prenatal Diagnosis/*ethics
EDAT- 2012/06/15 06:00
MHDA- 2013/04/25 06:00
CRDT- 2012/06/15 06:00
PHST- 2012/06/15 06:00 [entrez]
PHST- 2012/06/15 06:00 [pubmed]
PHST- 2013/04/25 06:00 [medline]
AID - S1744-165X(12)00061-3 [pii]
AID - 10.1016/j.siny.2012.05.006 [doi]
PST - ppublish
SO  - Semin Fetal Neonatal Med. 2012 Oct;17(5):252-5. doi: 10.1016/j.siny.2012.05.006. 
      Epub 2012 Jun 12.


PMID- 22695311
OWN - NLM
STAT- MEDLINE
DCOM- 20121226
LR  - 20120803
IS  - 1472-6491 (Electronic)
IS  - 1472-6483 (Linking)
VI  - 25
IP  - 2
DP  - 2012 Aug
TI  - IVF and embryo transfer: historical origin and development.
PG  - 118-27
LID - 10.1016/j.rbmo.2012.04.011 [doi]
AB  - IVF and embryo transfer for the treatment of human infertility has now resulted
      in the birth of over 4 million babies. The technique did not arise as a quantum
      event but was built on the efforts of many earlier workers in the fields of
      reproductive endocrinology and development. One should remember the famous saying
      of Isaac Newton: 'If I have seen further than most, it is because I have stood on
      the shoulder's of giants'. Ethical and moral issues have always arisen when
      investigators study early mammalian development, particularly human development. 
      This paper documents these earlier studies and also draws attention to the
      ethical and moral arguments that inevitably arose.
CI  - Copyright (c) 2012 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All
      rights reserved.
FAU - Biggers, John D
AU  - Biggers JD
AD  - Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
      john_biggers@hms.harvard.edu
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Review
DEP - 20120430
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
SB  - IM
MH  - Embryo Transfer/*history/*methods
MH  - Fertilization in Vitro/*history/*methods
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Reproductive Techniques, Assisted/*ethics/*history
EDAT- 2012/06/15 06:00
MHDA- 2012/12/27 06:00
CRDT- 2012/06/15 06:00
PHST- 2012/01/09 00:00 [received]
PHST- 2012/04/24 00:00 [revised]
PHST- 2012/04/24 00:00 [accepted]
PHST- 2012/06/15 06:00 [entrez]
PHST- 2012/06/15 06:00 [pubmed]
PHST- 2012/12/27 06:00 [medline]
AID - S1472-6483(12)00292-1 [pii]
AID - 10.1016/j.rbmo.2012.04.011 [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2012 Aug;25(2):118-27. doi: 10.1016/j.rbmo.2012.04.011.
      Epub 2012 Apr 30.


PMID- 22694036
OWN - NLM
STAT- MEDLINE
DCOM- 20120910
LR  - 20120614
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 12
IP  - 7
DP  - 2012
TI  - On the cutting edge: ethical responsiveness to cesarean rates.
PG  - 44-52
LID - 10.1080/15265161.2012.673689 [doi]
AB  - Cesarean delivery rates have been steadily increasing worldwide. In response,
      many countries have introduced target goals to reduce rates. But a focus on
      target goals fails to address practices embedded in standards of care that
      encourage, rather than discourage, cesarean sections. Obstetrical standards of
      care normalize use of technology, creating an imperative to use technology during
      labor and birth. A technological imperative is implicated in rising cesarean
      rates if physicians or patients fear refusing use of technology. Reproductive
      autonomy is at stake since a technological imperative undermines patients'
      ability to choose cesareans or refuse use of technology increasing the likelihood
      of cesareans. To address practices driven by a technological imperative I outline
      three physician obligations that are attached to respecting patient autonomy.
      These moral obligations show that a focus on respect for autonomy may prove not
      only an ideal ethical response but also an achievable practical response to
      lowering cesarean rates.
FAU - Burrow, Sylvia
AU  - Burrow S
AD  - Cape Breton University, Canada. sylvia_burrow@cbu.ca
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CIN - Am J Bioeth. 2012;12(7):1-2. PMID: 22694022
CIN - Am J Bioeth. 2012;12(7):53-4. PMID: 22694037
CIN - Am J Bioeth. 2012;12(7):54-6. PMID: 22694038
CIN - Am J Bioeth. 2012;12(7):56-8. PMID: 22694039
CIN - Am J Bioeth. 2012;12(7):58-9. PMID: 22694040
CIN - Am J Bioeth. 2012;12(7):59-61. PMID: 22694041
CIN - Am J Bioeth. 2012;12(7):61-2. PMID: 22694042
MH  - Cesarean Section/*ethics/*statistics & numerical data/trends
MH  - Choice Behavior/*ethics
MH  - Counseling
MH  - Defensive Medicine/*ethics/trends
MH  - Ethical Analysis
MH  - Ethical Theory
MH  - Ethics, Medical
MH  - Female
MH  - Humans
MH  - *Labor, Obstetric
MH  - *Moral Obligations
MH  - *Mothers/psychology
MH  - Obstetrics/*ethics/standards/trends
MH  - Patient Rights/*ethics/standards/trends
MH  - *Personal Autonomy
MH  - Physician-Patient Relations/*ethics
MH  - Physicians/ethics
MH  - Pregnancy
MH  - Reproductive Techniques/ethics/standards/trends
MH  - Risk
MH  - Standard of Care/ethics/standards/trends
MH  - United States/epidemiology
EDAT- 2012/06/15 06:00
MHDA- 2012/09/11 06:00
CRDT- 2012/06/15 06:00
PHST- 2012/06/15 06:00 [entrez]
PHST- 2012/06/15 06:00 [pubmed]
PHST- 2012/09/11 06:00 [medline]
AID - 10.1080/15265161.2012.673689 [doi]
PST - ppublish
SO  - Am J Bioeth. 2012;12(7):44-52. doi: 10.1080/15265161.2012.673689.


PMID- 22694032
OWN - NLM
STAT- MEDLINE
DCOM- 20120910
LR  - 20120614
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 12
IP  - 7
DP  - 2012
TI  - Ethical dilemma of mandated contraception in pharmaceutical research at catholic 
      medical institutions.
PG  - 34-7
LID - 10.1080/15265161.2012.680532 [doi]
AB  - The Catholic Church proscribes methods of birth control other than sexual
      abstinence. Although the U.S. Food and Drug Administration (FDA) recognizes
      abstinence as an acceptable method of birth control in research studies, some
      pharmaceutical companies mandate the use of artificial contraceptive techniques
      to avoid pregnancy as a condition for participation in their studies. These
      requirements are unacceptable at Catholic health care institutions, leading to
      conflicts among institutional review boards, clinical investigators, and
      sponsors. Subjects may feel coerced by such mandates to adopt contraceptive
      techniques inconsistent with their personal situation and beliefs; women
      committed to celibacy or who engage exclusively in non-heterosexual activities
      are negatively impacted. We propose principles to insure informed consent to
      safeguard the rights of research subjects at Catholic institutions while
      mitigating this ethical conflict. At the same time, our proposal respects the
      interests of pharmaceutical research agencies and Catholic moral precepts, and
      fully abides by regulatory guidance.
FAU - Casey, Murray Joseph
AU  - Casey MJ
AD  - Creighton University School of Medicine, USA.
FAU - O'Brien, Richard
AU  - O'Brien R
FAU - Rendell, Marc
AU  - Rendell M
FAU - Salzman, Todd
AU  - Salzman T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
RN  - 0 (Contraceptive Agents)
RN  - 0 (Drugs, Investigational)
RN  - 0 (Teratogens)
SB  - IM
CIN - Am J Bioeth. 2012;12(7):38-9. PMID: 22694033
CIN - Am J Bioeth. 2012;12(7):40-1. PMID: 22694034
CIN - Am J Bioeth. 2012;12(7):42-3. PMID: 22694035
MH  - *Catholicism
MH  - Clinical Trials as Topic/*ethics/methods
MH  - Contraceptive Agents/*administration & dosage
MH  - Drugs, Investigational/*adverse effects
MH  - Ethical Analysis
MH  - Ethics, Research
MH  - Female
MH  - Hospitals, Religious/ethics
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Pregnancy
MH  - Pregnancy Tests
MH  - Research Subjects/supply & distribution
MH  - Schools, Medical/ethics
MH  - Sexual Abstinence
MH  - *Teratogens
MH  - United States
MH  - United States Food and Drug Administration
EDAT- 2012/06/15 06:00
MHDA- 2012/09/11 06:00
CRDT- 2012/06/15 06:00
PHST- 2012/06/15 06:00 [entrez]
PHST- 2012/06/15 06:00 [pubmed]
PHST- 2012/09/11 06:00 [medline]
AID - 10.1080/15265161.2012.680532 [doi]
PST - ppublish
SO  - Am J Bioeth. 2012;12(7):34-7. doi: 10.1080/15265161.2012.680532.


PMID- 22693975
OWN - NLM
STAT- MEDLINE
DCOM- 20120807
LR  - 20191112
IS  - 0006-9248 (Print)
IS  - 0006-9248 (Linking)
VI  - 113
IP  - 6
DP  - 2012
TI  - Distribution of HLA antigens in breast cancer.
PG  - 372-5
AB  - Investigation of various tumor-specific markers has a critical role in early
      diagnosis and treatment of breast cancer. The aim of the this study is to
      investigate the Human Leukocyte Antigen (HLA) alleles, the molecules that play an
      important role in immunity and tumor response of the body, and its relationship
      with breast cancer. In this prospective clinical study, after obtaining approval 
      from the ethics committee of Istanbul University Experimental Medical Research
      Institute, 22 female patients who have been hospitalized in Istanbul University
      Cerrahpasa Faculty of Medicine the Department of General Surgery with a diagnosis
      of breast cancer were selected. In the control group, there were 22 healthy women
      who had no relationship and were donor candidates for renal transplantation.
      After collecting blood in 5 ml tubes with EDTA, HLA A, B and DR groups were
      measured with SSP method using the GenoVision Olerup SSP (Olerup SSP, Stockholm, 
      Sweden) kit in Istanbul University Cerrahpasa Faculty of Medicine Blood Center
      Tissue Type Determination Laboratory. In patient and control group, totally 53
      alleles; 17 alleles of HLA-A gene, 22 alleles of B gene, 14 alleles of DR gene
      were detected. A statistically significant relationship was determined between
      HLA-B55:01 and HLA-DRb1*18:01 alleles and the development of breast cancer
      (p<0.05). HLA-B13:01 antigen is determined only in the control group. It was
      concluded that HLA-B13:01 antigen, determined only in the control group, may be
      protective for breast cancer and HLA-B55:01 and HLA-DRb1*18:01 antigens,
      determined only in the patient group, may be a risk factor for breast cancer
      (Tab. 5, Ref. 22).
FAU - Bayraktar, B
AU  - Bayraktar B
AD  - Department of General Surgery, Istanbul University, Cerrahpasa Medical School,
      Istanbul, Turkey.
FAU - Yilmaz, E
AU  - Yilmaz E
FAU - Bayraktar, O
AU  - Bayraktar O
FAU - Apaydin, B B
AU  - Apaydin BB
FAU - Erguner, I E
AU  - Erguner IE
FAU - Kayabasi, B
AU  - Kayabasi B
FAU - Ozcelik, A A
AU  - Ozcelik AA
FAU - Eren, B
AU  - Eren B
LA  - eng
PT  - Journal Article
PL  - Slovakia
TA  - Bratisl Lek Listy
JT  - Bratislavske lekarske listy
JID - 0065324
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Breast Neoplasms/*genetics
MH  - Female
MH  - HLA Antigens/*analysis
MH  - Humans
MH  - Middle Aged
MH  - Risk Factors
EDAT- 2012/06/15 06:00
MHDA- 2012/08/08 06:00
CRDT- 2012/06/15 06:00
PHST- 2012/06/15 06:00 [entrez]
PHST- 2012/06/15 06:00 [pubmed]
PHST- 2012/08/08 06:00 [medline]
AID - 10.4149/bll_2012_084 [doi]
PST - ppublish
SO  - Bratisl Lek Listy. 2012;113(6):372-5. doi: 10.4149/bll_2012_084.


PMID- 25181248
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140903
LR  - 20211021
IS  - 2279-9028 (Print)
IS  - 2279-9028 (Linking)
VI  - 1
IP  - 2
DP  - 2012 Jun 15
TI  - Effect of Education of Primary Health Care Workers on HIV-related Oral Lesions in
      Nairobi East District.
PG  - 137-40
LID - 10.4081/jphr.2012.e20 [doi]
AB  - BACKGROUND: An estimated 90% of HIV-infected people are likely to develop oral
      lesions in the course of HIV infection. Oro-pharyngeal candidiasis (OPC), an
      early marker for HIV-infection, can be diagnosed during an oral examination (OE).
      Primary healthcare (PHC) providers in Kenya are neither trained nor sufficiently 
      equipped to perform this simple, cheap and non-invasive examination. The PHC
      system in Kenya offers an opportunity to integrate early recognition and
      management of oral lesions into general health care. This study aims to estimate 
      the effect of a multifaceted intervention for PHC providers in training them to
      perform an OE. Specifically, our primary objective is to establish whether the
      intervention is effective in increasing: i) the frequency of early detection of
      HIV-related oral lesions; and ii) referral rates for HIV-testing. DESIGN AND
      METHODS: THE STUDY HAS BEEN DESIGNED IN TWO PARTS: a retrospective clinical data 
      record study and a prospective cohort study with pre-post control group design,
      carried out in 2 administrative divisions in Nairobi East district. The
      intervention group will receive one day of training on recognition of HIV-related
      oral lesions and other common oral conditions. Reminder sessions will be held at 
      individual health facilities. Routine tally sheets will be used to record all
      patients with HIV-related oral lesions, dental caries and periodontal disease. A 
      convenience sample of all the PHC in a division will be used. It will not be
      possible to blind investigators or assessors. Expected impact of the study for
      Public Health. Early recognition and treatment of HIV infection influences
      long-term survival rates and will reduce healthcare expenditure. ACKNOWLEDGMENTS:
      The project is funded by the Netherlands organisation for international
      cooperation in higher education (NUFFIC). We would like to thank all
      participating health facilities and health care workers for their willingness to 
      take part in this study. LNK also thanks the Kenya Ministry of Public Health and 
      Sanitation for permission to carry out this study. We also thank Mr. J Mulder
      from Radboud University Nijmegen Medical Centre, Department of Methodology,
      Information Management and Statistics, Nijmegen, The Netherlands for statistical 
      advice. FUNDING: THIS STUDY IS FUNDED BY A RESEARCH GRANT FROM THE NETHERLANDS
      ORGANIZATION FOR INTERNATIONAL COOPERATION IN HIGHER EDUCATION (NUFFIC, GRANT NR:
      C&B-NFP-PHD.10/110), The Hague, The Netherlands. TRIAL REGISTRATION: Netherlands 
      Trial Register NTR2627 (date registered 22(nd) November 2010). ETHICS APPROVAL:
      Kenyatta National Hospital/University of Nairobi Ethics and Research Committee
      (approval number KNH-ERC/A/474), and The Ministry of Public Health and Sanitation
      (Ref. N. MPHS/IB/1/14 Vol. III).
FAU - Koyio, Lucina N
AU  - Koyio LN
AD  - Department of Oral and Maxillofacial Surgery, University of Nairobi Dental
      Teaching Hospital , Nairobi, Kenya.
FAU - van der Sanden, Wil J M
AU  - van der Sanden WJ
AD  - Department of Global Oral Health, College of Oral Sciences, Radboud University
      Nijmegen Medical Centre , Nijmgen, The Netherlands.
FAU - van der Ven, Andre
AU  - van der Ven A
AD  - Department of General Internal Medicine, Nijmgen Institute for Infection,
      Inflammation and Immunity, Radboud University Nijmgen Medical Centre , Nijmgen,
      The Netherlands.
FAU - Creugers, Nico
AU  - Creugers N
AD  - Department of Oral Function, College of Oral Sciences, Radboud University
      Nijmegen Medical Centre , Nijmgen, The Netherlands.
FAU - Merkx, Matthias A W
AU  - Merkx MA
AD  - Department of Oral and Maxillofacial Surgery, Radboud University Nijmegen Medical
      Centre , Nijmgen, The Netherlands.
FAU - Frencken, Jo E
AU  - Frencken JE
AD  - Department of Global Oral Health, College of Oral Sciences, Radboud University
      Nijmegen Medical Centre , Nijmgen, The Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20120430
PL  - United States
TA  - J Public Health Res
JT  - Journal of public health research
JID - 101580775
PMC - PMC4140363
OTO - NOTNLM
OT  - AIDS/HIV
OT  - detection
OT  - mucosal lesion
EDAT- 2012/06/15 00:00
MHDA- 2012/06/15 00:01
CRDT- 2014/09/03 06:00
PHST- 2012/03/12 00:00 [received]
PHST- 2012/03/15 00:00 [accepted]
PHST- 2014/09/03 06:00 [entrez]
PHST- 2012/06/15 00:00 [pubmed]
PHST- 2012/06/15 00:01 [medline]
AID - 10.4081/jphr.2012.e20 [doi]
PST - epublish
SO  - J Public Health Res. 2012 Apr 30;1(2):137-40. doi: 10.4081/jphr.2012.e20.
      eCollection 2012 Jun 15.


PMID- 22693699
OWN - NLM
STAT- MEDLINE
DCOM- 20130311
LR  - 20191210
IS  - 2042-8189 (Electronic)
IS  - 1478-2715 (Linking)
VI  - 42
IP  - 2
DP  - 2012 Jun
TI  - Methadone replacement therapy: tried, tested, effective?
PG  - 133-8
LID - 10.4997/JRCPE.2012.210 [doi]
AB  - Methadone prescription is a controversial topic. While many believe that it is an
      effective treatment for opiate dependency, others argue that it is not successful
      in reducing either the addiction or even injecting behaviour. In this debate, Dr 
      Robertson makes the case that methadone has been well tested, is cheap and
      acceptable to the patient and results in visible improvement. Dr Daniels argues
      that methadone treatment is philosophically ill-conceived, ethically dubious, and
      costly. He also highlights evidence that the treatment is potentially harmful to 
      both patients and those in contact with them.
FAU - Robertson, J R
AU  - Robertson JR
AD  - Muirhouse Medical Group and Clinical Reader, University of Edinburgh, Scotland,
      UK.
FAU - Daniels, A M
AU  - Daniels AM
LA  - eng
PT  - Journal Article
PL  - England
TA  - J R Coll Physicians Edinb
JT  - The journal of the Royal College of Physicians of Edinburgh
JID - 101144324
RN  - 0 (Narcotics)
RN  - UC6VBE7V1Z (Methadone)
SB  - IM
MH  - Behavior, Addictive/*drug therapy
MH  - Health Care Costs
MH  - Humans
MH  - Methadone/*therapeutic use
MH  - Narcotics/*therapeutic use
MH  - *Opiate Substitution Treatment/ethics
MH  - Opioid-Related Disorders/*drug therapy
MH  - *Outcome Assessment, Health Care
MH  - Patient Satisfaction
MH  - Philosophy, Medical
MH  - Prescriptions
MH  - Treatment Outcome
EDAT- 2012/06/14 06:00
MHDA- 2013/03/12 06:00
CRDT- 2012/06/14 06:00
PHST- 2012/06/14 06:00 [entrez]
PHST- 2012/06/14 06:00 [pubmed]
PHST- 2013/03/12 06:00 [medline]
AID - 10.4997/JRCPE.2012.210 [doi]
PST - ppublish
SO  - J R Coll Physicians Edinb. 2012 Jun;42(2):133-8. doi: 10.4997/JRCPE.2012.210.


PMID- 22692859
OWN - NLM
STAT- MEDLINE
DCOM- 20130108
LR  - 20220318
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 11
DP  - 2012 Nov
TI  - Evaluating a patient's request for life-prolonging treatment: an ethical
      framework.
PG  - 647-51
LID - 10.1136/medethics-2011-100333 [doi]
AB  - Contrary to the widespread concern about over-treatment at the end of life,
      today, patient preferences for palliative care at the end of life are frequently 
      respected. However, ethically challenging situations in the current healthcare
      climate are, instead, situations in which a competent patient requests active
      treatment with the goal of life-prolongation while the physician suggests best
      supportive care only. The argument of futility has often been used to justify
      unilateral decisions made by physicians to withhold or withdraw life-sustaining
      treatment. However, we argue that neither the concept of futility nor that of
      patient autonomy alone is apt for resolving situations in which physicians are
      confronted with patients' requests for active treatment. Instead, we integrate
      the relevant arguments that have been put forward in the academic discussion
      about 'futile' treatment into an ethical algorithm with five guiding questions:
      (1) Is there a chance that medical intervention will be effective in achieving
      the patient's treatment goal? (2) How does the physician evaluate the expected
      benefit and the potential harm of the treatment? (3) Does the patient understand 
      his or her medical situation? (4) Does the patient prefer receiving treatment
      after evaluating the benefit-harm ratio and the costs? (5) Does the treatment
      require many resources? This algorithm shall facilitate approaching patients'
      requests for treatments deemed futile by the physician in a systematic way, and
      responding to these requests in an ethically appropriate manner. It thereby adds 
      substantive considerations to the current procedural approaches of conflict
      resolution in order to improve decision making among physicians, patients and
      families.
FAU - Winkler, Eva C
AU  - Winkler EC
AD  - National Center for Tumour Diseases, University of Heidelberg, Heidelberg,
      Germany. eva.winkler@med.uni-heidelberg.de
FAU - Hiddemann, Wolfgang
AU  - Hiddemann W
FAU - Marckmann, Georg
AU  - Marckmann G
LA  - eng
PT  - Journal Article
DEP - 20120612
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Algorithms
MH  - *Checklist
MH  - Choice Behavior/ethics
MH  - Decision Making/*ethics
MH  - Dissent and Disputes
MH  - Ethics, Medical
MH  - Humans
MH  - *Life Expectancy
MH  - *Medical Futility
MH  - *Palliative Care/economics/ethics/trends
MH  - *Patient Care Planning/ethics/standards/trends
MH  - *Patients
MH  - Personal Autonomy
MH  - Physician-Patient Relations/ethics
MH  - Physicians/*ethics
MH  - Practice Patterns, Physicians'/economics/*ethics/standards/trends
MH  - Terminal Care/ethics/standards/trends
MH  - Treatment Outcome
MH  - *Withholding Treatment/economics/ethics/trends
PMC - PMC3582068
EDAT- 2012/06/14 06:00
MHDA- 2013/01/09 06:00
CRDT- 2012/06/14 06:00
PHST- 2012/06/14 06:00 [entrez]
PHST- 2012/06/14 06:00 [pubmed]
PHST- 2013/01/09 06:00 [medline]
AID - medethics-2011-100333 [pii]
AID - 10.1136/medethics-2011-100333 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Nov;38(11):647-51. doi: 10.1136/medethics-2011-100333. Epub
      2012 Jun 12.


PMID- 22692805
OWN - NLM
STAT- MEDLINE
DCOM- 20121023
LR  - 20211021
IS  - 1740-7753 (Electronic)
IS  - 1740-7745 (Linking)
VI  - 9
IP  - 3
DP  - 2012 Jun
TI  - Establishing HIV treatment as prevention in the HIV Prevention Trials Network 052
      randomized trial: an ethical odyssey.
PG  - 340-7
LID - 10.1177/1740774512443594 [doi]
AB  - BACKGROUND: Obtaining the definitive data necessary to determine the safety and
      efficacy of using antiretroviral treatment (ART) to reduce the sexual
      transmission of HIV in heterosexual couples encountered an array of ethical
      challenges that threatened to compromise HIV Prevention Trials Network (HPTN)
      052, the multinational clinical trial addressing this issue that has profound
      public health implications. PURPOSE: To describe and analyze the major ethical
      challenges faced in HPTN 052. METHODS: The ethical issues and modifications of
      HPTN 052 in response to these issues were cataloged by the principal
      investigator, the lead coordinator, and the ethicist working on the trial. The
      major ethical issues that were unique to the trial were then described and
      analyzed in light of the published literature as well as guidances and policies. 
      The ethical challenges that must be addressed in many clinical trials, such as
      those related to obtaining informed consent and making provisions for ancillary
      care, are not described. RESULTS: When HPTN 052 was being designed, ethical
      questions emerged related to the relevance of the research question itself given 
      data from observational research and a range of beliefs about the appropriate
      means of preventing and treating HIV infection and AIDS. Furthermore, ethical
      challenges were faced regarding site selection since there was a scientific need 
      to conduct the research in settings where HIV incidence was high, but
      alternatives to study participation should be available. As in most
      HIV-prevention research, ethical questions surrounded the determination of the
      appropriate prevention package for all of those enrolled. During the course of
      the trial, guidance documents and policies emerged that were of direct relevance 
      to the research questions, calling for a balancing of concerns for the research
      subjects and trial integrity. When the study results were made public, there was 
      a need to ensure access to the treatment shown to be effective that in some cases
      differed from the guidelines used at the sites where the research was being
      conducted. In addition, questions were raised about whether there was an
      obligation to notify subjects about 'unlinked' transmissions of HIV, that is,
      infections acquired from someone other than the designated sexual partner
      enrolled in the study. LIMITATIONS: The ethical issues described are limited to
      those discerned by the authors and not those of other stakeholders who may have
      identified additional issues or had a different perspective in analyzing them.
      CONCLUSIONS: Understanding the ethical challenges faced in HPTN 052 promises to
      inform the design and conduct of future complex, long-term clinical trials aimed 
      at addressing critical scientific and public health questions, where data and
      practice patterns emerge over the course of the trial.
FAU - Cohen, Myron S
AU  - Cohen MS
AD  - University of North Carolina at Chapel Hill, USA.
FAU - McCauley, Marybeth
AU  - McCauley M
FAU - Sugarman, Jeremy
AU  - Sugarman J
LA  - eng
GR  - U01 AI068619/AI/NIAID NIH HHS/United States
GR  - UL1 TR000454/TR/NCATS NIH HHS/United States
GR  - UM1 AI068619/AI/NIAID NIH HHS/United States
GR  - UL1 RR025008/RR/NCRR NIH HHS/United States
GR  - P30 AI050410/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - Clin Trials
JT  - Clinical trials (London, England)
JID - 101197451
RN  - 0 (Anti-Retroviral Agents)
SB  - IM
MH  - Anti-Retroviral Agents/adverse effects/*therapeutic use
MH  - Biomedical Research/*ethics
MH  - Female
MH  - *HIV Infections/drug therapy/prevention & control/transmission
MH  - Heterosexuality
MH  - Humans
MH  - Male
MH  - Randomized Controlled Trials as Topic/*ethics
PMC - PMC3486723
MID - NIHMS409417
EDAT- 2012/06/14 06:00
MHDA- 2012/10/24 06:00
CRDT- 2012/06/14 06:00
PHST- 2012/06/14 06:00 [entrez]
PHST- 2012/06/14 06:00 [pubmed]
PHST- 2012/10/24 06:00 [medline]
AID - 9/3/340 [pii]
AID - 10.1177/1740774512443594 [doi]
PST - ppublish
SO  - Clin Trials. 2012 Jun;9(3):340-7. doi: 10.1177/1740774512443594.


PMID- 22692169
OWN - NLM
STAT- MEDLINE
DCOM- 20120615
LR  - 20161017
IS  - 1538-3598 (Electronic)
IS  - 0098-7484 (Linking)
VI  - 307
IP  - 22
DP  - 2012 Jun 13
TI  - Adaptive trials in clinical research: scientific and ethical issues to consider.
PG  - 2379-80
LID - 10.1001/jama.2012.6380 [doi]
FAU - van der Graaf, Rieke
AU  - van der Graaf R
AD  - University Medical Center Utrecht, Utrecht, The Netherlands.
      r.vandergraaf@umcutrecht.nl
FAU - Roes, Kit C B
AU  - Roes KC
FAU - van Delden, Johannes J M
AU  - van Delden JJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - JAMA
JT  - JAMA
JID - 7501160
SB  - IM
MH  - *Ethics, Research
MH  - Humans
MH  - Informed Consent
MH  - Patient Selection
MH  - Randomized Controlled Trials as Topic/*ethics
MH  - Reproducibility of Results
MH  - *Research Design
MH  - *Social Values
EDAT- 2012/06/14 06:00
MHDA- 2012/06/16 06:00
CRDT- 2012/06/14 06:00
PHST- 2012/06/14 06:00 [entrez]
PHST- 2012/06/14 06:00 [pubmed]
PHST- 2012/06/16 06:00 [medline]
AID - 1182329 [pii]
AID - 10.1001/jama.2012.6380 [doi]
PST - ppublish
SO  - JAMA. 2012 Jun 13;307(22):2379-80. doi: 10.1001/jama.2012.6380.


PMID- 22692040
OWN - NLM
STAT- MEDLINE
DCOM- 20121024
LR  - 20220321
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 264
IP  - 2
DP  - 2012 Aug
TI  - Radiofrequency ablation as a substitute for surgery in elderly patients with
      nonresected breast cancer: pilot study with long-term outcomes.
PG  - 597-605
LID - 10.1148/radiol.12111303 [doi]
AB  - PURPOSE: To determine the efficacy and tolerance of ultrasonography (US)-guided
      percutaneous radiofrequency (RF) ablation with endocrine therapy in elderly
      patients with breast cancer who decline or are not candidates for surgery.
      MATERIALS AND METHODS: Internal ethics committee approval was obtained, and
      patients gave informed written consent. Women older than 70 years with breast
      carcinoma, who had undergone neoadjuvant endocrine therapy within the past 6
      months, underwent US-guided RF ablation while under local anesthesia and
      sedation. Only tumors measuring 3 cm or smaller and situated at least 1 cm from
      the skin, nipple, and chest wall were selected. Multitine electrodes were used.
      Endocrine therapy was continued for a total of 5 years, and breast irradiation
      was not performed. Clinical follow-up included US, mammography, and dynamic
      contrast material-enhanced (DCE) magnetic resonance (MR) imaging every 2 months
      for 6 months and then every 6 months until 5 years. Primary end points were RF
      ablation efficacy at 1 year on the basis of DCE MR imaging follow-up and
      procedural tolerance. The secondary end point was delayed local efficacy at the
      end of endocrine therapy (5 years) on the basis of DCE MR imaging follow-up.
      RESULTS: Twenty-one women were treated from December 2004 to April 2010 (median
      age, 79 years; age range, 70-88 years). Efficacy was demonstrated at 1 year, with
      only one patient presenting with a local relapse. No general complications were
      noted. Skin burn occurred in four patients, with spontaneous healing after a
      maximum of 2 months. Ten patients were followed up for 5 years, with three
      additional patients presenting with cancer recurrence outside the ablation zone
      at 30, 48, and 60 months-including two with lobular carcinoma. Four patients died
      during the full follow-up, two of breast cancer-related causes and two of
      unrelated causes. CONCLUSION: RF ablation in elderly patients with nonresected
      breast cancer is well tolerated and efficient at 1-year follow-up. The technique 
      is not recommended for lobular carcinoma.
FAU - Palussiere, Jean
AU  - Palussiere J
AD  - Department of Interventional Radiology, Institut Bergonie, Bordeaux, France.
      J.Palussiere@bordeaux.unicancer.fr
FAU - Henriques, Corinne
AU  - Henriques C
FAU - Mauriac, Louis
AU  - Mauriac L
FAU - Asad-Syed, Maryam
AU  - Asad-Syed M
FAU - Valentin, Fabienne
AU  - Valentin F
FAU - Brouste, Veronique
AU  - Brouste V
FAU - Mathoulin-Pelissier, Simone
AU  - Mathoulin-Pelissier S
FAU - Tunon de Lara, Christine
AU  - Tunon de Lara C
FAU - Debled, Marc
AU  - Debled M
LA  - eng
PT  - Journal Article
DEP - 20120612
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
SB  - IM
CIN - Radiology. 2013 Oct;269(1):309-10. PMID: 24062564
CIN - Radiology. 2013 Oct;269(1):310. PMID: 24191348
MH  - Aged
MH  - Aged, 80 and over
MH  - Breast Neoplasms/pathology/*surgery
MH  - Catheter Ablation/*methods
MH  - Contrast Media
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Mammography
MH  - Neoadjuvant Therapy
MH  - Pilot Projects
MH  - Prospective Studies
MH  - Treatment Outcome
MH  - *Ultrasonography, Interventional
EDAT- 2012/06/14 06:00
MHDA- 2012/10/25 06:00
CRDT- 2012/06/14 06:00
PHST- 2012/06/14 06:00 [entrez]
PHST- 2012/06/14 06:00 [pubmed]
PHST- 2012/10/25 06:00 [medline]
AID - radiol.12111303 [pii]
AID - 10.1148/radiol.12111303 [doi]
PST - ppublish
SO  - Radiology. 2012 Aug;264(2):597-605. doi: 10.1148/radiol.12111303. Epub 2012 Jun
      12.


PMID- 22692038
OWN - NLM
STAT- MEDLINE
DCOM- 20121024
LR  - 20220410
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 264
IP  - 2
DP  - 2012 Aug
TI  - Colon tumor growth and antivascular treatment in mice: complementary assessment
      with MR elastography and diffusion-weighted MR imaging.
PG  - 436-44
AB  - PURPOSE: To investigate the potential value of magnetic resonance (MR)
      elastography and diffusion-weighted (DW) MR imaging in the detection of
      microstructural changes of murine colon tumors during growth and antivascular
      treatment. MATERIALS AND METHODS: The study was approved by the regional ethics
      committee for animal care. Sixty Balb-C mice, bearing ectopic and orthotopic
      colon tumors, were monitored for 3 weeks with high-resolution T2-weighted MR
      imaging, three-dimensional steady-state MR elastography, and DW MR imaging at 7
      T. The same imaging protocol was performed 24 hours after injection of
      combretastatin A4 phosphate (CA4P) in 12 mice. The absolute value of the complex 
      shear modulus (|G*|) and the apparent diffusion coefficient (ADC) were measured
      in the viable zones of tumors and compared with microvessel density (MVD),
      cellularity, and micronecrosis by using the Pearson correlation coefficient.
      RESULTS: During tumor growth, |G*| increase was correlated with MVD (r = 0.70 [P 
      = .08] and r = 0.78 [P = .002], for both the ectopic and orthotopic models,
      respectively). Moreover, the ectopic tumors displayed decreased ADC, which
      correlated with increased cellularity (r = 0.77, P = .04), whereas no changes in 
      ADC and cellularity were observed in orthotopic tumors. After CA4P
      administration, |G*| decreased in the ectopic model (P < .0001), similar to the
      MVD evolution (P = .03), whereas no significant changes in |G*| (P = .7) and MVD 
      (P = .6) were observed in the orthotopic model. ADC increased in both models (P =
      .047 and P = .01 for the ectopic and the orthotopic models, respectively) in
      relation to increased micronecrosis. CONCLUSION: Imaging of mechanical properties
      and diffusivity provide complementary information during tumor growth and
      regression that are respectively linked to vascularity and tumor cell
      alterations, including cellularity and micronecrosis.
FAU - Juge, Lauriane
AU  - Juge L
AD  - Universite Paris Diderot, Centre de Recherche Biomedicale Bichat Beaujon, Clichy,
      France. lauriane.juge@inserm.fr
FAU - Doan, Bich-Thuy
AU  - Doan BT
FAU - Seguin, Johanne
AU  - Seguin J
FAU - Albuquerque, Miguel
AU  - Albuquerque M
FAU - Larrat, Benoit
AU  - Larrat B
FAU - Mignet, Nathalie
AU  - Mignet N
FAU - Chabot, Guy G
AU  - Chabot GG
FAU - Scherman, Daniel
AU  - Scherman D
FAU - Paradis, Valerie
AU  - Paradis V
FAU - Vilgrain, Valerie
AU  - Vilgrain V
FAU - Van Beers, Bernard E
AU  - Van Beers BE
FAU - Sinkus, Ralph
AU  - Sinkus R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120612
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Stilbenes)
RN  - I5590ES2QZ (fosbretabulin)
SB  - IM
MH  - Animals
MH  - Colonic Neoplasms/*drug therapy/*pathology
MH  - Diffusion Magnetic Resonance Imaging/*methods
MH  - Elasticity Imaging Techniques/*methods
MH  - Female
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Microcirculation/drug effects
MH  - Neovascularization, Pathologic/*drug therapy/*pathology
MH  - Stilbenes/*pharmacology
EDAT- 2012/06/14 06:00
MHDA- 2012/10/25 06:00
CRDT- 2012/06/14 06:00
PHST- 2012/06/14 06:00 [entrez]
PHST- 2012/06/14 06:00 [pubmed]
PHST- 2012/10/25 06:00 [medline]
AID - radiol.12111548 [pii]
AID - 10.1148/radiol.12111548 [doi]
PST - ppublish
SO  - Radiology. 2012 Aug;264(2):436-44. doi: 10.1148/radiol.12111548. Epub 2012 Jun
      12.


PMID- 22691690
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20220310
IS  - 2110-5820 (Electronic)
IS  - 2110-5820 (Linking)
VI  - 2
IP  - 1
DP  - 2012 Jun 12
TI  - The critically-ill pediatric hemato-oncology patient: epidemiology, management,
      and strategy of transfer to the pediatric intensive care unit.
PG  - 14
LID - 10.1186/2110-5820-2-14 [doi]
AB  - Cancer is a leading cause of death in children. In the past decades, there has
      been a marked increase in overall survival of children with cancer. However,
      children whose treatment includes hematopoietic stem cell transplantation still
      represent a subpopulation with a higher risk of mortality. These improvements in 
      mortality are accompanied by an increase in complications, such as respiratory
      and cardiovascular insufficiencies as well as neurological problems that may
      require an admission to the pediatric intensive care unit where most supportive
      therapies can be provided. It has been shown that ventilatory and cardiovascular 
      support along with renal replacement therapy can benefit pediatric
      hemato-oncology patients if promptly established. Even if admissions of these
      patients are not considered futile anymore, they still raise sensitive questions,
      including ethical issues. To support the discussion and potentially facilitate
      the decision-making process, we propose an algorithm that takes into account the 
      reason for admission (surgical versus medical) and the hemato-oncological
      prognosis. The algorithm then leads to different types of admission: full-support
      admission, "pediatric intensive care unit trial" admission, intensive care with
      adapted level of support, and palliative intensive care. Throughout the process, 
      maintaining a dialogue between the treating physicians, the paramedical staff,
      the child, and his parents is of paramount importance to optimize the care of
      these children with complex disease and evolving medical status.
FAU - Demaret, Pierre
AU  - Demaret P
AD  - Division of pediatric critical care medicine, Department of Pediatrics,
      Sainte-Justine Hospital, Chemin de la Cote-Sainte-Catherine, Montreal, H2J3V6,
      Canada. demaret.pierre@gmail.com.
FAU - Pettersen, Geraldine
AU  - Pettersen G
FAU - Hubert, Philippe
AU  - Hubert P
FAU - Teira, Pierre
AU  - Teira P
FAU - Emeriaud, Guillaume
AU  - Emeriaud G
LA  - eng
PT  - Journal Article
DEP - 20120612
PL  - Germany
TA  - Ann Intensive Care
JT  - Annals of intensive care
JID - 101562873
PMC - PMC3423066
EDAT- 2012/06/14 06:00
MHDA- 2012/06/14 06:01
CRDT- 2012/06/14 06:00
PHST- 2012/01/16 00:00 [received]
PHST- 2012/06/12 00:00 [accepted]
PHST- 2012/06/14 06:00 [entrez]
PHST- 2012/06/14 06:00 [pubmed]
PHST- 2012/06/14 06:01 [medline]
AID - 2110-5820-2-14 [pii]
AID - 10.1186/2110-5820-2-14 [doi]
PST - epublish
SO  - Ann Intensive Care. 2012 Jun 12;2(1):14. doi: 10.1186/2110-5820-2-14.


PMID- 22691601
OWN - NLM
STAT- MEDLINE
DCOM- 20130319
LR  - 20121119
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 19
IP  - 6
DP  - 2012 Nov
TI  - Clinical research ethics in Irish healthcare: diversity, dynamism and
      medicalization.
PG  - 810-8
LID - 10.1177/0969733011431191 [doi]
AB  - Gaining ethical clearance to conduct a study is an important aspect of all
      research involving humans but can be time-consuming and daunting for novice
      researchers. This article stems from a larger ethnographic study that examined
      research capacity building in Irish nursing and midwifery. Data were collected
      over a 28-month time frame from a purposive sample of 16 nurse or midwife
      research fellows who were funded to undertake full-time PhDs. Gaining ethical
      clearance for their studies was reported as an early 'rite of passage' in the
      category of 'labouring the doctorate'. This article penetrates the complexities
      in Irish clinical research ethics by describing the practices these nurse and
      midwife researchers encountered and the experiences they had. The key issue of
      representation that occurred in the context of 'medicalized' research ethics is
      further explored including its meaning for nursing or midwifery research.
FAU - Condell, Sarah L
AU  - Condell SL
AD  - Dr Steevens' Hospital, Ireland. sarah.condell@hse.ie
FAU - Begley, Cecily
AU  - Begley C
LA  - eng
PT  - Journal Article
DEP - 20120612
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Anthropology, Cultural
MH  - *Capacity Building
MH  - Clinical Nursing Research/*ethics/organization & administration
MH  - Delivery of Health Care/*organization & administration
MH  - Female
MH  - Humans
MH  - Ireland
MH  - Longitudinal Studies
MH  - Medicalization
MH  - Midwifery
MH  - Pregnancy
EDAT- 2012/06/14 06:00
MHDA- 2013/03/21 06:00
CRDT- 2012/06/14 06:00
PHST- 2012/06/14 06:00 [entrez]
PHST- 2012/06/14 06:00 [pubmed]
PHST- 2013/03/21 06:00 [medline]
AID - 0969733011431191 [pii]
AID - 10.1177/0969733011431191 [doi]
PST - ppublish
SO  - Nurs Ethics. 2012 Nov;19(6):810-8. doi: 10.1177/0969733011431191. Epub 2012 Jun
      12.


PMID- 22691600
OWN - NLM
STAT- MEDLINE
DCOM- 20120927
LR  - 20120703
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 19
IP  - 4
DP  - 2012 Jul
TI  - The relationship of ethics education to moral sensitivity and moral reasoning
      skills of nursing students.
PG  - 568-80
LID - 10.1177/0969733011433922 [doi]
AB  - This study described the relationships between academic class and student moral
      sensitivity and reasoning and between curriculum design components for ethics
      education and student moral sensitivity and reasoning. The data were collected
      from freshman (n = 506) and senior students (n = 440) in eight baccalaureate
      nursing programs in South Korea by survey; the survey consisted of the Korean
      Moral Sensitivity Questionnaire and the Korean Defining Issues Test. The results 
      showed that moral sensitivity scores in patient-oriented care and conflict were
      higher in senior students than in freshman students. Furthermore, more hours of
      ethics content were associated with higher principled thinking scores of senior
      students. Nursing education in South Korea may have an impact on developing
      student moral sensitivity. Planned ethics content in nursing curricula is
      necessary to improve moral sensitivity and moral reasoning of students.
FAU - Park, Mihyun
AU  - Park M
AD  - Research Institute for Hospice/Palliative Care, College of Nursing, Catholic
      University of Korea, 505 Banpo-dong, Seoch-gu, Seoul 137-701, Korea.
      marivincent@gmail.com
FAU - Kjervik, Diane
AU  - Kjervik D
FAU - Crandell, Jamie
AU  - Crandell J
FAU - Oermann, Marilyn H
AU  - Oermann MH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120612
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Cross-Sectional Studies
MH  - Curriculum
MH  - Education, Nursing, Baccalaureate/*organization & administration
MH  - Ethics, Nursing/*education
MH  - Female
MH  - Humans
MH  - Male
MH  - *Moral Development
MH  - Nursing Education Research
MH  - Nursing Evaluation Research
MH  - Nursing Methodology Research
MH  - Republic of Korea
MH  - Students, Nursing/*psychology
MH  - Thinking/*ethics
MH  - Young Adult
EDAT- 2012/06/14 06:00
MHDA- 2012/09/28 06:00
CRDT- 2012/06/14 06:00
PHST- 2012/06/14 06:00 [entrez]
PHST- 2012/06/14 06:00 [pubmed]
PHST- 2012/09/28 06:00 [medline]
AID - 0969733011433922 [pii]
AID - 10.1177/0969733011433922 [doi]
PST - ppublish
SO  - Nurs Ethics. 2012 Jul;19(4):568-80. doi: 10.1177/0969733011433922. Epub 2012 Jun 
      12.


PMID- 22690811
OWN - NLM
STAT- MEDLINE
DCOM- 20140508
LR  - 20190318
IS  - 1865-1682 (Electronic)
IS  - 1865-1674 (Linking)
VI  - 60
IP  - 4
DP  - 2013 Aug
TI  - Minimization of the impact of Aujeszky's disease outbreaks in The Netherlands: a 
      conceptual framework.
PG  - 303-14
LID - 10.1111/j.1865-1682.2012.01348.x [doi]
AB  - In the Netherlands, outbreaks of Aujeszky's Disease (AD) are controlled by
      vaccination and movement restriction zones (MRZ). Although this strategy avoids
      the socio-ethical concerns associated with pre-emptive slaughter, it can easily
      result in animal welfare problems and negative economic consequences. These arise
      because movement restrictions result in surpluses of live (vaccinated) piglets on
      farms. The aim is to provide insight into the development of these surpluses and 
      its impact and to describe how measures that allow early transportation of pigs
      under certain conditions and to specific destinations (channelling) could reduce 
      these problems. For the analysis, a deterministic simulation model was developed,
      which calculates surpluses of piglets at multiplier farms during AD outbreaks.
      This is performed on a weekly basis for two areas (with and without piglet
      surplus), three outbreak durations (minimum, moderate and long) and three
      strategies for movement restrictions (strict, transports within the MRZ allowed
      and transports outside the MRZ allowed). The results show that in case of
      complete movement restrictions, surpluses of piglets varying in age and
      vaccination status will quickly arise. These surpluses are larger for longer
      epidemics and can become as large as 180-340 thousand piglets (45-75% of weekly
      domestic production) for moderate and long epidemics, respectively.
      Implementation of channelling strategies that allow earlier transportation within
      the MRZ can reduce surpluses by about 50% to 100-150 thousand piglets maximum.
      Strategies that also allow transportation outside the MRZ can reduce surpluses
      even further to below 100 thousand piglets. It was concluded that channelling of 
      live piglets during AD outbreaks results in a drastic reduction of problems with 
      accommodating ready-for-transport piglets. Moreover, it reduces shortages during 
      movement restrictions and peak supply immediately after removing the
      restrictions. Channelling could therefore be an important instrument to reduce
      the economic and animal welfare impacts of containment measures.
CI  - (c) 2012 Blackwell Verlag GmbH.
FAU - Bosman, K J
AU  - Bosman KJ
AD  - Business Economics Group, Wageningen University, Hollandseweg 1, Wageningen, The 
      Netherlands. koenraad.bosman@wur.nl
FAU - Mourits, M C M
AU  - Mourits MC
FAU - Oude Lansink, A G J M
AU  - Oude Lansink AG
FAU - Saatkamp, H W
AU  - Saatkamp HW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120612
PL  - Germany
TA  - Transbound Emerg Dis
JT  - Transboundary and emerging diseases
JID - 101319538
SB  - IM
MH  - Animals
MH  - Communicable Disease Control/*methods
MH  - Computer Simulation
MH  - Disease Outbreaks/prevention & control/*veterinary
MH  - Models, Theoretical
MH  - Netherlands/epidemiology
MH  - Pseudorabies/epidemiology/*prevention & control/transmission
MH  - Swine
MH  - *Transportation
MH  - Vaccination/*veterinary
OTO - NOTNLM
OT  - Aujeszky's disease
OT  - animal welfare
OT  - disease control
OT  - movement restrictions
OT  - trade
EDAT- 2012/06/14 06:00
MHDA- 2014/05/09 06:00
CRDT- 2012/06/14 06:00
PHST- 2012/06/14 06:00 [entrez]
PHST- 2012/06/14 06:00 [pubmed]
PHST- 2014/05/09 06:00 [medline]
AID - 10.1111/j.1865-1682.2012.01348.x [doi]
PST - ppublish
SO  - Transbound Emerg Dis. 2013 Aug;60(4):303-14. doi:
      10.1111/j.1865-1682.2012.01348.x. Epub 2012 Jun 12.


PMID- 22690746
OWN - NLM
STAT- MEDLINE
DCOM- 20130603
LR  - 20220409
IS  - 1423-0410 (Electronic)
IS  - 0042-9007 (Linking)
VI  - 103
IP  - 4
DP  - 2012 Nov
TI  - Expert Consensus Statement on achieving self-sufficiency in safe blood and blood 
      products, based on voluntary non-remunerated blood donation (VNRBD).
PG  - 337-42
LID - 10.1111/j.1423-0410.2012.01630.x [doi]
AB  - All countries face challenges in making sufficient supplies of blood and blood
      products available and sustainable, while also ensuring the quality and safety of
      these products in the face of known and emerging threats to public health. Since 
      1975, the World Health Assembly (WHA) has highlighted the global need for blood
      safety and availability. WHA resolutions 63.12, 58.13 and 28.72, The Melbourne
      Declaration on 100% Voluntary Non-Remunerated Donation of Blood and Blood
      Components and WHO Global Blood Safety Network recommendations have reaffirmed
      the achievement of 'Self-sufficiency in blood and blood products based on
      voluntary non-remunerated blood donation (VNRBD)' as the important national
      policy direction for ensuring a safe, secure and sufficient supply of blood and
      blood products, including labile blood components and plasma-derived medicinal
      products. Despite some successes, self-sufficiency is not yet a reality in many
      countries. A consultation of experts, convened by the World Health Organization
      (WHO) in September 2011 in Geneva, Switzerland, addressed the urgent need to
      establish strategies and mechanisms for achieving self-sufficiency. Information
      on the current situation, and country perspectives and experiences were shared.
      Factors influencing the global implementation of self-sufficiency, including
      safety, ethics, security and sustainability of supply, trade and its potential
      impact on public health, availability and access for patients, were analysed to
      define strategies and mechanisms and provide practical guidance on achieving
      self-sufficiency. Experts developed a consensus statement outlining the rationale
      and definition of self-sufficiency in safe blood and blood products based on
      VNRBD and made recommendations to national health authorities and WHO.
CI  - (c) 2012 World Health Organization. Vox Sanguinis (c) 2012 International Society 
      of Blood Transfusion.
CN  - WHO Expert Group
LA  - eng
PT  - Consensus Development Conference
PT  - Journal Article
DEP - 20120613
PL  - England
TA  - Vox Sang
JT  - Vox sanguinis
JID - 0413606
SB  - IM
MH  - Blood Banks/standards
MH  - *Blood Donors
MH  - Blood Safety/methods/*standards
MH  - Blood Transfusion/*standards
MH  - Guidelines as Topic
MH  - Health Services Accessibility/organization & administration
MH  - Human Experimentation
MH  - Humans
MH  - Safety Management/organization & administration
MH  - World Health Organization
IR  - Amin NA
FIR - Amin, Noryati Abu
IR  - Armstrong D
FIR - Armstrong, Duncan
IR  - Behr-Gross ME
FIR - Behr-Gross, Marie-Emmanuelle
IR  - Beyer P
FIR - Beyer, Peter
IR  - Charoonruangrit U
FIR - Charoonruangrit, Ubonwon
IR  - Chitsva J
FIR - Chitsva, James
IR  - Cruz JR
FIR - Cruz, Jose Ramiro
IR  - David B
FIR - David, Bernard
IR  - De Wit J
FIR - De Wit, Jeroen
IR  - Dhingra N
FIR - Dhingra, Neelam
IR  - Fischer Y
FIR - Fischer, Yvonne
IR  - Flanagan P
FIR - Flanagan, Peter
IR  - Dongying G
FIR - Dongying, Gao
IR  - Grazzini G
FIR - Grazzini, Giuliano
IR  - Gunasekera A
FIR - Gunasekera, Ananda
IR  - Ping H
FIR - Ping, Hui
IR  - Kabra S
FIR - Kabra, Sandhya
IR  - Kit LC
FIR - Kit, Lin Che
IR  - Matsumoto J
FIR - Matsumoto, Jun
IR  - M'baya B
FIR - M'baya, Bridon
IR  - McDonald P
FIR - McDonald, Peter
IR  - Miyake S
FIR - Miyake, Satoru
IR  - Moftah F
FIR - Moftah, Faten
IR  - Mpuntsha-Motau L
FIR - Mpuntsha-Motau, Loyiso
IR  - Mvere D
FIR - Mvere, David
IR  - Nabae K
FIR - Nabae, Koji
IR  - Nozaki S
FIR - Nozaki, Shinjiro
IR  - Rogers P
FIR - Rogers, Paul
IR  - Sobaga L
FIR - Sobaga, Leslie
IR  - Steed A
FIR - Steed, Anthony
IR  - Tapko JB
FIR - Tapko, Jean-Baptiste
IR  - Teo DL
FIR - Teo, Diana Lay Tin
IR  - Van Der Poel CL
FIR - Van Der Poel, Cornelis L
IR  - Van Lerberghe W
FIR - Van Lerberghe, Wim
IR  - Villanueva S
FIR - Villanueva, Silvia
IR  - Yee E
FIR - Yee, Edward
IR  - Junping Y
FIR - Junping, Yu
EDAT- 2012/06/14 06:00
MHDA- 2013/06/05 06:00
CRDT- 2012/06/14 06:00
PHST- 2012/06/14 06:00 [entrez]
PHST- 2012/06/14 06:00 [pubmed]
PHST- 2013/06/05 06:00 [medline]
AID - 10.1111/j.1423-0410.2012.01630.x [doi]
PST - ppublish
SO  - Vox Sang. 2012 Nov;103(4):337-42. doi: 10.1111/j.1423-0410.2012.01630.x. Epub
      2012 Jun 13.


PMID- 22690543
OWN - NLM
STAT- MEDLINE
DCOM- 20120723
LR  - 20120613
IS  - 0044-4677 (Print)
IS  - 0044-4677 (Linking)
VI  - 62
IP  - 2
DP  - 2012 Mar-Apr
TI  - ["Brain reading": achievements, perspectives and ethical problems].
PG  - 133-42
AB  - The new trend in brain research designated as brain reading is considered. This
      research deals with decoding the informational content of the brain processing
      via its physiological parameters. Such studies are based on rather complicated
      methods of mathematical analysis. Single records rather than averaged data are
      used to reveal their content. Three main streams of studies are distinguished,
      i.e. the object classification, the emotion recognition and brainotyping.
      Particularly, the studies directed to recognizing the type of thinking via EEG
      spectra, carried out in the author's laboratory, are reviewed. The possible
      outcome of the brain reading technique is considered. Finally it is argued that
      in the future, the broad application of this technique needs to be controlled
      with some ethical rules.
FAU - Ivanitskii, A M
AU  - Ivanitskii AM
LA  - rus
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Russia (Federation)
TA  - Zh Vyssh Nerv Deiat Im I P Pavlova
JT  - Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova
JID - 9421551
SB  - IM
MH  - Brain/*physiology
MH  - Brain Mapping/*ethics/*trends
MH  - Electroencephalography/methods
MH  - Higher Nervous Activity/*physiology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Pattern Recognition, Physiological/*physiology
EDAT- 2012/06/14 06:00
MHDA- 2012/07/24 06:00
CRDT- 2012/06/14 06:00
PHST- 2012/06/14 06:00 [entrez]
PHST- 2012/06/14 06:00 [pubmed]
PHST- 2012/07/24 06:00 [medline]
PST - ppublish
SO  - Zh Vyssh Nerv Deiat Im I P Pavlova. 2012 Mar-Apr;62(2):133-42.


PMID- 22690133
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1474-2837 (Print)
IS  - 1474-2829 (Linking)
VI  - 11
IP  - 2
DP  - 2012
TI  - Reflexive Research Ethics for Environmental Health and Justice: Academics and
      Movement-Building.
PG  - 161-176
AB  - Community-engaged research on environmental problems has reshaped
      researcher-participant relationships, academic-community interaction, and the
      role of community partners in human subjects protection and ethical oversight. We
      draw on our own and others' research collaborations with environmental health and
      justice social movement organizations to discuss the ethical concerns that emerge
      in community-engaged research. In this paper we introduce the concept of
      reflexive research ethics: ethical guidelines and decision-making principles that
      depend on continual reflexivity concerning the relationships between researchers 
      and participants. Seeing ethics in this way can help scientists conduct research 
      that simultaneously achieves a high level of professional conduct and protects
      the rights, well-being, and autonomy of both researchers and the multiple publics
      affected by research. We highlight our research with community-based
      organizations in Massachusetts, California, and Alaska, and discuss the potential
      impacts of the community or social movement on the research process and the
      potential impacts of research on community or social movement goals. We conclude 
      by discussing ways in which the ethical concerns that surface in
      community-engaged research have led to advances in ethical research practices.
      This type of work raises ethical questions whose answers are broadly relevant for
      social movement, environmental, and public health scholars.
FAU - Cordner, Alissa
AU  - Cordner A
AD  - Sociology Department, Brown University, Providence, USA.
FAU - Ciplet, David
AU  - Ciplet D
FAU - Brown, Phil
AU  - Brown P
FAU - Morello-Frosch, Rachel
AU  - Morello-Frosch R
LA  - eng
GR  - R01 ES017514/ES/NIEHS NIH HHS/United States
GR  - R01 ES017514-04/ES/NIEHS NIH HHS/United States
GR  - R25 ES013258/ES/NIEHS NIH HHS/United States
PT  - Journal Article
DEP - 20120402
PL  - England
TA  - Soc Mov Stud
JT  - Social movement studies
JID - 101580844
PMC - PMC3370411
MID - NIHMS363507
EDAT- 2012/06/13 06:00
MHDA- 2012/06/13 06:01
CRDT- 2012/06/13 06:00
PHST- 2012/06/13 06:00 [entrez]
PHST- 2012/06/13 06:00 [pubmed]
PHST- 2012/06/13 06:01 [medline]
AID - 10.1080/14742837.2012.664898 [doi]
PST - ppublish
SO  - Soc Mov Stud. 2012;11(2):161-176. doi: 10.1080/14742837.2012.664898. Epub 2012
      Apr 2.


PMID- 22690043
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2229-7707 (Electronic)
IS  - 0976-9668 (Linking)
VI  - 3
IP  - 1
DP  - 2012 Jan
TI  - Effectively communicating the 5R's (replace, reduce, refine, reuse, and
      rehabilitate) of research ethics, biomedical waste, personalized medicines and
      the rest.
PG  - 1-2
LID - 10.4103/0976-9668.95932 [doi]
FAU - Kumar, Arun H S
AU  - Kumar AH
AD  - Editor in Chief, Journal Natural Science Biology and Medicine, India E-mail:
      editor@jnsbm.org.
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Nat Sci Biol Med
JT  - Journal of natural science, biology, and medicine
JID - 101571070
PMC - PMC3361767
EDAT- 2012/06/13 06:00
MHDA- 2012/06/13 06:01
CRDT- 2012/06/13 06:00
PHST- 2012/06/13 06:00 [entrez]
PHST- 2012/06/13 06:00 [pubmed]
PHST- 2012/06/13 06:01 [medline]
AID - 10.4103/0976-9668.95932 [doi]
AID - JNSBM-3-1 [pii]
PST - ppublish
SO  - J Nat Sci Biol Med. 2012 Jan;3(1):1-2. doi: 10.4103/0976-9668.95932.


PMID- 22689787
OWN - NLM
STAT- MEDLINE
DCOM- 20121023
LR  - 20120612
IS  - 1548-9221 (Electronic)
IS  - 1548-9221 (Linking)
VI  - 27
IP  - 3
DP  - 2012 Jun
TI  - From pluripotency to distinct cardiomyocyte subtypes.
PG  - 119-29
LID - 10.1152/physiol.00044.2011 [doi]
AB  - Differentiated adult cardiomyocytes (CMs) lack significant regenerative
      potential, which is one reason why degenerative heart diseases are the leading
      cause of death in the western world. For future cardiac repair, stem cell-based
      therapeutic strategies may become alternatives to donor heart transplantation.
      The principle of reprogramming adult terminally differentiated cells (iPSC) had a
      major impact on stem cell biology. One can now generate autologous pluripotent
      cells that highly resemble embryonic stem cells (ESC) and that are ethically
      inoffensive as opposed to human ESC. Yet, due to genetic and epigenetic
      aberrations arising during the full reprogramming process, it is questionable
      whether iPSC will enter the clinic in the near future. Therefore, the recent
      achievement of directly reprogramming fibroblasts into cardiomyocytes via a
      milder approach, thereby avoiding an initial pluripotent state, may become of
      great importance. In addition, various clinical scenarios will depend on the
      availability of specific cardiac cellular subtypes, for which a first step was
      achieved via our own programming approach to achieve cardiovascular cell
      subtypes. In this review, we discuss recent progress in the cardiovascular stem
      cell field addressing the above mentioned aspects.
FAU - David, Robert
AU  - David R
AD  - 1st Medical Department, University of Munich, Campus Grosshadern, Munich,
      Germany.
FAU - Franz, Wolfgang-Michael
AU  - Franz WM
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Physiology (Bethesda)
JT  - Physiology (Bethesda, Md.)
JID - 101208185
SB  - IM
MH  - Adult
MH  - *Cell Differentiation
MH  - Embryonic Stem Cells/cytology/transplantation
MH  - Humans
MH  - Myocytes, Cardiac/*cytology/transplantation
MH  - Pluripotent Stem Cells/*cytology/transplantation
MH  - Stem Cell Transplantation
EDAT- 2012/06/13 06:00
MHDA- 2012/10/24 06:00
CRDT- 2012/06/13 06:00
PHST- 2012/06/13 06:00 [entrez]
PHST- 2012/06/13 06:00 [pubmed]
PHST- 2012/10/24 06:00 [medline]
AID - 27/3/119 [pii]
AID - 10.1152/physiol.00044.2011 [doi]
PST - ppublish
SO  - Physiology (Bethesda). 2012 Jun;27(3):119-29. doi: 10.1152/physiol.00044.2011.


PMID- 22689709
OWN - NLM
STAT- MEDLINE
DCOM- 20121220
LR  - 20201209
IS  - 1531-1937 (Electronic)
IS  - 0897-1900 (Linking)
VI  - 25
IP  - 4
DP  - 2012 Aug
TI  - Clinical application of pharmacogenomics.
PG  - 417-27
LID - 10.1177/0897190012448309 [doi]
AB  - The purpose of this review is to discuss the clinical application of
      pharmacogenomics for select drug therapies (eg, proton pump inhibitors [PPIs],
      codeine, and carbamazepine) and to highlight limitations and challenges that
      preclude implementation of pharmacogenomics into clinical practice. Genetic
      polymorphisms of cytochrome P450 (CYP) enzymes and the presence of the human
      leukocyte antigen (HLA)-B*1502 allele influence drug disposition and/or response.
      A portion of PPI pharmacokinetic and pharmacodynamic variability can be explained
      by CYP2C19 genotype. However, conflicting evidence exists related to Helicobacter
      pylori cure rates based on CYP2C19 genotype. For codeine, adverse drug reactions 
      in neonates through breast-feeding from CYP2D6 ultra-rapid metabolizers have been
      reported. However, there is lack of conclusive evidence regarding the overall
      influence of CYP2D6 polymorphisms on codeine efficacy and toxicity. Although
      CYP2C19 and CYP2D6 genotyping tests are available, clinical utility remains low. 
      The presence of the HLA-B*1502 allele is associated with carbamazepine-induced
      Stevens-Johnson syndrome (SJS) and/or toxic epidermal necrolysis (TEN).
      Pharmacogenomic testing is required prior to initiating carbamazepine in
      high-risk patients. Lack of sufficient resources, provider knowledge, and
      ethical, legal, and social issues are several limitations and challenges to
      implementing pharmacogenomic testing in clinical practice.
FAU - Ma, Joseph D
AU  - Ma JD
AD  - Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California,
      San Diego, La Jolla, CA 92093, USA. joema@ucsd.edu
FAU - Lee, Kelly C
AU  - Lee KC
FAU - Kuo, Grace M
AU  - Kuo GM
LA  - eng
GR  - 1U38GD000070/GD/OGDP CDC HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
DEP - 20120611
PL  - United States
TA  - J Pharm Pract
JT  - Journal of pharmacy practice
JID - 8900945
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Anticonvulsants)
RN  - 0 (Proton Pump Inhibitors)
RN  - 33CM23913M (Carbamazepine)
RN  - 9035-51-2 (Cytochrome P-450 Enzyme System)
RN  - UX6OWY2V7J (Codeine)
SB  - IM
MH  - Analgesics, Opioid/*administration & dosage/adverse effects
MH  - Anticonvulsants/*administration & dosage/adverse effects
MH  - Carbamazepine/*administration & dosage/adverse effects
MH  - Codeine/*administration & dosage/adverse effects
MH  - Cytochrome P-450 Enzyme System/genetics
MH  - Dose-Response Relationship, Drug
MH  - Genotype
MH  - Humans
MH  - *Pharmacogenetics/standards
MH  - Polymorphism, Genetic/drug effects
MH  - Proton Pump Inhibitors/*administration & dosage/adverse effects
MH  - Risk Factors
EDAT- 2012/06/13 06:00
MHDA- 2012/12/21 06:00
CRDT- 2012/06/13 06:00
PHST- 2012/06/13 06:00 [entrez]
PHST- 2012/06/13 06:00 [pubmed]
PHST- 2012/12/21 06:00 [medline]
AID - 0897190012448309 [pii]
AID - 10.1177/0897190012448309 [doi]
PST - ppublish
SO  - J Pharm Pract. 2012 Aug;25(4):417-27. doi: 10.1177/0897190012448309. Epub 2012
      Jun 11.


PMID- 22689123
OWN - NLM
STAT- MEDLINE
DCOM- 20130318
LR  - 20131112
IS  - 0717-6163 (Electronic)
IS  - 0034-9887 (Linking)
VI  - 140
IP  - 3
DP  - 2012 Mar
TI  - [Scientific ethics and the use of human material or data].
PG  - 390-5
LID - 10.4067/S0034-98872012000300018 [doi]
LID - S0034-98872012000300018 [pii]
AB  - A scientific article censured by superposing obstacles to its reading remembers
      the censure of Galileo made by the Inquisition. The censure followed the failure 
      to obtain the informed consent (IC) to disclose results of old samples. At
      present, the use of collected data or samples for a new research needs a new IC, 
      in most ethical protocols. The Helsinki Code allows the research ethics
      committees the authorization for the use of that information. This norm is
      founded rather in commercial, legal or protective arguments than in ethical
      bases. This article criticizes this norm from the Scientific Ethics viewpoint
      because: i) the ownership of the genome and environment that originate a person
      is not of such person but of the human society and Homo sapiens species, ii) a
      person is not the unique owner of that information; laboratories, institutions,
      health services and research teams add constituents to it, iii) several
      violations to this norm occurring in medical, labor, legal and social practice
      show it as biased against science, iv) if this stored information and its use are
      beneficial for humankind (its proper owner) it is ethically obligatory to use it.
      It is proposed to create an anonymous World Bank for Human Information with open 
      access and universal transparency. This universal collection of data handled
      under universal accepted ethical norms should prevent exclusive private use of
      public information, non-publication of negative results, illicit and unethical
      use of human data.
FAU - Valenzuela, Carlos Y
AU  - Valenzuela CY
AD  - Programa de Genetica Humana, ICBM, Facultad de Medicina, Universidad de Chile,
      Chile. cvalenzu@med.uchile.cl
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Etica Cientifica y uso de material o datos colectados de seres humanos.
PL  - Chile
TA  - Rev Med Chil
JT  - Revista medica de Chile
JID - 0404312
SB  - IM
MH  - Bioethical Issues
MH  - Biological Specimen Banks/*ethics
MH  - *Ethics, Medical
MH  - Helsinki Declaration
MH  - Human Genome Project
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Specimen Handling/*ethics
EDAT- 2012/06/13 06:00
MHDA- 2013/03/19 06:00
CRDT- 2012/06/13 06:00
PHST- 2011/04/14 00:00 [received]
PHST- 2011/10/18 00:00 [accepted]
PHST- 2012/06/13 06:00 [entrez]
PHST- 2012/06/13 06:00 [pubmed]
PHST- 2013/03/19 06:00 [medline]
AID - S0034-98872012000300018 [pii]
AID - 10.4067/S0034-98872012000300018 [doi]
PST - ppublish
SO  - Rev Med Chil. 2012 Mar;140(3):390-5. doi: 10.4067/S0034-98872012000300018.


PMID- 22688721
OWN - NLM
STAT- MEDLINE
DCOM- 20120904
LR  - 20211021
IS  - 1572-8633 (Electronic)
IS  - 1386-7423 (Linking)
VI  - 15
IP  - 3
DP  - 2012 Aug
TI  - Ethics of autism.
PG  - 253-4
LID - 10.1007/s11019-012-9422-8 [doi]
FAU - Gordijn, Bert
AU  - Gordijn B
FAU - ten Have, Henk
AU  - ten Have H
LA  - eng
PT  - Editorial
PT  - Introductory Journal Article
PL  - Netherlands
TA  - Med Health Care Philos
JT  - Medicine, health care, and philosophy
JID - 9815900
SB  - IM
MH  - *Autistic Disorder/psychology/therapy
MH  - Deception
MH  - *Ethics, Medical
MH  - Humans
MH  - Interpersonal Relations
EDAT- 2012/06/13 06:00
MHDA- 2012/09/05 06:00
CRDT- 2012/06/13 06:00
PHST- 2012/06/13 06:00 [entrez]
PHST- 2012/06/13 06:00 [pubmed]
PHST- 2012/09/05 06:00 [medline]
AID - 10.1007/s11019-012-9422-8 [doi]
PST - ppublish
SO  - Med Health Care Philos. 2012 Aug;15(3):253-4. doi: 10.1007/s11019-012-9422-8.


PMID- 22688209
OWN - NLM
STAT- MEDLINE
DCOM- 20121026
LR  - 20191027
IS  - 1710-2774 (Print)
IS  - 1710-2774 (Linking)
VI  - 15
IP  - 2
DP  - 2012
TI  - Service guidelines based on Resource Utilization Groups Version III for Home Care
      provide decision-making support for case managers.
PG  - 75-81
AB  - Increasing costs and budget reductions combined with increasing demand from our
      growing, aging population support the need to ensure that the scarce resources
      allocated to home care clients match client needs. This article details how
      Integrated Home Care for the Calgary Zone of Alberta Health Services considered
      ethical and economic principles and used data from the Resident Assessment
      Instrument for Home Care (RAI-HC) and case mix indices from the Resource
      Utilization Groups Version III for Home Care (RUG-III/HC) to formulate service
      guidelines. These explicit service guidelines formalize and support individual
      resource allocation decisions made by case managers and provide a consistent and 
      transparent method of allocating limited resources.
FAU - Collister, Barbara
AU  - Collister B
AD  - Integrated Home Care, Calgary Zone, Alberta Health Services.
FAU - Stein, Glenda
AU  - Stein G
FAU - Katz, Deborah
AU  - Katz D
FAU - DeBruyn, Joan
AU  - DeBruyn J
FAU - Andrusiw, Linda
AU  - Andrusiw L
FAU - Cloutier, Sheila
AU  - Cloutier S
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Healthc Q
JT  - Healthcare quarterly (Toronto, Ont.)
JID - 101208192
MH  - Alberta
MH  - Case Management/organization & administration/*standards
MH  - Decision Making
MH  - Home Care Services/organization & administration/*standards
MH  - Humans
MH  - *Practice Guidelines as Topic/standards
MH  - Resource Allocation/*standards
EDAT- 2012/06/13 06:00
MHDA- 2012/10/27 06:00
CRDT- 2012/06/13 06:00
PHST- 2012/06/13 06:00 [entrez]
PHST- 2012/06/13 06:00 [pubmed]
PHST- 2012/10/27 06:00 [medline]
AID - 10.12927/hcq.2012.22909 [doi]
PST - ppublish
SO  - Healthc Q. 2012;15(2):75-81. doi: 10.12927/hcq.2012.22909.


PMID- 22686712
OWN - NLM
STAT- MEDLINE
DCOM- 20120921
LR  - 20191210
IS  - 0970-258X (Print)
IS  - 0970-258X (Linking)
VI  - 25
IP  - 2
DP  - 2012 Mar-Apr
TI  - Assessment of Health-Related Quality of Life in school-going adolescents:
      validation of PedsQL instrument and comparison with WHOQOL-BREF.
PG  - 74-9
AB  - BACKGROUND: Health-Related Quality of Life (HRQoL) studies are gaining
      importance. Yet there is a dearth of crossculturally validated generic HRQoL
      instruments for Indian adolescents. Two HRQoL instruments, namely World Health
      Organization Quality of Life-Brief (WHOQOL-BREF) and Pediatric Quality of Life
      inventory 4.0 (PedsQL), are widely used internationally, with both measuring four
      domains (physical, psychological/emotional, social relations and
      environment/school) but each having different questions with 26 in the former and
      23 in the latter. This study was done among adolescents in the city of Lucknow to
      evaluate the psychometric properties of PedsQL and compare its performance with
      previously validated and culturally revised WHOQOL-BREF. METHODS: This
      cross-sectional study was conducted in February 2010 after institutional ethical 
      approval. Data were collected by a self-administered, redesigned questionnaire in
      which items of PedsQL and revised WHOQOL-BREF were intermingled. Reliability,
      content and construct validity were evaluated for PedsQL. Convergent validity of 
      PedsQL with revised WHOQOL-BREF was calculated for domains with similar
      questions. RESULTS: Parents of 76.5% adolescents (385/503) provided consent. Mean
      age of adolescents was 13.6 years (1.6 SD and 44.7% were girls). PedsQL showed
      substantial reliability (Cronbach alpha=0.82, p<0.00001) but poor to fair
      validity as compared to revised WHOQOL-BREF. CONCLUSIONS: For Indian adolescents,
      PedsQL is a reliable and valid instrument. However, on comparison with revised
      WHOQOL-BREF, PedsQL has poor to fair validity. We conclude that revised
      WHOQOL-BREF is a better HRQoL instrument for Indian adolescents.
CI  - Copyright 2012, NMJI.
FAU - Awasthi, S
AU  - Awasthi S
AD  - Department of Paediatrics, Chhattrapati Shahuji Maharaj Medical University,
      Shahmina Road, Chowk, Lucknow, Uttar Pradesh 226003, India.shallya@rediffmail.com
FAU - Agnihotri, K
AU  - Agnihotri K
FAU - Chandra, H
AU  - Chandra H
FAU - Singh, U
AU  - Singh U
FAU - Thakur, S
AU  - Thakur S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
PL  - India
TA  - Natl Med J India
JT  - The National medical journal of India
JID - 8809315
SB  - IM
MH  - Adolescent
MH  - Female
MH  - Humans
MH  - Male
MH  - Psychology, Adolescent
MH  - Psychometrics
MH  - Quality of Life/*psychology
MH  - Reproducibility of Results
MH  - *Surveys and Questionnaires
EDAT- 2012/06/13 06:00
MHDA- 2012/09/22 06:00
CRDT- 2012/06/13 06:00
PHST- 2012/06/13 06:00 [entrez]
PHST- 2012/06/13 06:00 [pubmed]
PHST- 2012/09/22 06:00 [medline]
PST - ppublish
SO  - Natl Med J India. 2012 Mar-Apr;25(2):74-9.


PMID- 22686632
OWN - NLM
STAT- MEDLINE
DCOM- 20121030
LR  - 20120612
IS  - 1545-5815 (Electronic)
IS  - 0898-9621 (Linking)
VI  - 19
IP  - 3
DP  - 2012 May
TI  - Overcoming liability concerns in vaccine trials involving pregnant women.
PG  - 156-74
LID - 10.1080/08989621.2012.678686 [doi]
AB  - Without the protection of vaccines, the health of pregnant women may be
      compromised. But assessing the safety and efficacy of vaccines in pregnancy
      requires research in pregnancy. Furthermore, vaccinating women while they are
      pregnant may convey immunity to the fetus in utero, but assessing this possible
      benefit of maternal immunization also requires research. This article argues that
      one factor inhibiting vaccine research involving pregnant women is that vaccine
      manufacturers fear incurring liability if they fund such research. We argue that 
      vaccine research in pregnancy can be ethical, and we explore some methods for
      overcoming vaccine manufacturers' fear of liability.
FAU - Kaposy, Chris
AU  - Kaposy C
AD  - Faculty of Medicine, Memorial University of Newfoundland, St. John's,
      Newfoundland, Canada. christopher.kaposy@med.mun.ca
FAU - Lafferty, Lorraine
AU  - Lafferty L
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Account Res
JT  - Accountability in research
JID - 9100813
RN  - 0 (Vaccines)
SB  - IM
MH  - Biomedical Research/economics/*legislation & jurisprudence
MH  - Drug Industry/economics/*legislation & jurisprudence
MH  - Female
MH  - Fetus/immunology
MH  - Humans
MH  - *Liability, Legal
MH  - *Pregnancy/immunology
MH  - Research Support as Topic/legislation & jurisprudence
MH  - United States
MH  - *Vaccines/administration & dosage/immunology
EDAT- 2012/06/13 06:00
MHDA- 2012/10/31 06:00
CRDT- 2012/06/13 06:00
PHST- 2012/06/13 06:00 [entrez]
PHST- 2012/06/13 06:00 [pubmed]
PHST- 2012/10/31 06:00 [medline]
AID - 10.1080/08989621.2012.678686 [doi]
PST - ppublish
SO  - Account Res. 2012 May;19(3):156-74. doi: 10.1080/08989621.2012.678686.


PMID- 22686509
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20171116
IS  - 1365-3083 (Electronic)
IS  - 0300-9475 (Linking)
VI  - 76
IP  - 1
DP  - 2012 Jul
TI  - CD4- and CD3-T lymphocyte reference values of immunocompetent urban and rural
      subjects in an African nation.
PG  - 33-8
LID - 10.1111/j.1365-3083.2012.02700.x [doi]
AB  - Studies on the reference values of CD4 and CD3 T cells in healthy individuals
      have continued to gain significance because of the importance of these
      immunological markers in the initiation of combination antiretroviral therapy
      (cART). The aim of the present study was to determine and compare the reference
      values of CD4 and CD3 T cells in urban and rural Nigerians who were human
      immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV)
      negative. After ethical clearance and informed consent, 1123 subjects who met the
      inclusion criteria [mean age = 24.4 (+/- 11.2) years] were recruited in this
      study. Blood samples were analysed using the BD FACScount cytometer according to 
      the manufacturer's instructions. Of the overall 1123 subjects, reference means of
      CD4, CD3 and CD4/CD3 ratio were 1030 +/- 367, 1757 +/- 609 cells/mul and 0.59 +/-
      0.08, respectively. Five hundred and fifty-one (49.1%) were an urban population
      with the mean CD4, CD3 and CD4/CD3 T cell ratio of 1032 +/- 369, 1761 +/- 612
      cells/mul and 0.59 (+/-0.08), respectively. The remaining 572 (50.9%) were of a
      rural population with the mean CD4, CD3 and CD4/CD3 T cell ratio of 1028 +/- 459,
      1753 +/- 958 cells/mul and 0.59 +/- 0.13, respectively. Subjects with higher CD4 
      and CD3 T cells were more likely to be female than male (P < 0.05). There was no 
      significant difference between the T cell values of the two populations (P >
      0.05). Our findings provide new insight in the CD4 and CD3 T cell reference
      values of Nigerians.
CI  - (c) 2012 The Authors. Scandinavian Journal of Immunology (c) 2012 Blackwell
      Publishing Ltd.
FAU - Adoga, M P
AU  - Adoga MP
AD  - Microbiology Unit, Department of Biological Sciences, Nasarawa State University, 
      Keffi, Nigeria. adogamoses@yahoo.com
FAU - Pennap, G R
AU  - Pennap GR
FAU - John, P A
AU  - John PA
FAU - Shawulu, P T
AU  - Shawulu PT
FAU - Kaba, S V
AU  - Kaba SV
FAU - Forbi, J C
AU  - Forbi JC
FAU - Agwale, S M
AU  - Agwale SM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Scand J Immunol
JT  - Scandinavian journal of immunology
JID - 0323767
RN  - 0 (CD3 Complex)
RN  - 0 (CD4 Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - CD3 Complex/blood/*immunology
MH  - CD4 Antigens/blood/*immunology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Flow Cytometry
MH  - Humans
MH  - Leukocytes, Mononuclear
MH  - Male
MH  - Nigeria
MH  - Reference Values
MH  - Rural Population
MH  - T-Lymphocytes/*immunology
MH  - Urban Population
MH  - Young Adult
EDAT- 2012/06/13 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/06/13 06:00
PHST- 2012/06/13 06:00 [entrez]
PHST- 2012/06/13 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
AID - 10.1111/j.1365-3083.2012.02700.x [doi]
PST - ppublish
SO  - Scand J Immunol. 2012 Jul;76(1):33-8. doi: 10.1111/j.1365-3083.2012.02700.x.


PMID- 22686445
OWN - NLM
STAT- MEDLINE
DCOM- 20121217
LR  - 20211021
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 13
DP  - 2012 Jun 11
TI  - Are students kidding with health research ethics? The case of HIV/AIDS research
      in Cameroon.
PG  - 12
LID - 10.1186/1472-6939-13-12 [doi]
AB  - BACKGROUND: Universities in Cameroon are playing an active part in HIV/AIDS
      research and much of this research is carried out by students, usually for the
      purpose of a dissertation/thesis. Student theses/dissertations present research
      findings in a much more comprehensive manner and have been described as the
      stepping-stone of a budding scientist's potential in becoming an independent
      researcher. It is therefore important to verify how students handle issues of
      research ethics. METHOD: Theses/dissertations on HIV/AIDS that described research
      studies involving the use of human research participants were screened to verify 
      if research ethics approval and informed consent were obtained and documented.
      The contents of the consent forms were also qualitatively analyzed. RESULTS: Of
      174 theses/dissertations on HIV, ethics approval was documented in 17 (9.77%) and
      informed consent in 77 (47.83%). Research ethics approval was first mentioned at 
      all in 2002 and highly reported in the year 2007. Evidence of ethics approval was
      found for the first time in 2005 and informed consent first observed and
      evidenced in 1997. Ethics approval was mostly reported by students studying for
      an MD (14.01%) and was not reported in any Bachelors' degree dissertation.
      Informed consent was also highly reported in MD theses (64.58%) followed by
      undergraduate theses (31.58%). Voluntary participation and potential benefits of 
      the study were some of the common aspects dealt with in most of the consent
      forms. The right to discontinue participation in the study and management of
      residual samples were scarcely ever mentioned. CONCLUSIONS: Overall, and given
      the current state of the art of research ethics around the world,
      student-scientists in Cameroon would seem to be merely kidding with research
      ethics. It is thus essential that training in health research ethics (HRE) be
      incorporated in the curriculum of universities in Cameroon in order that the next
      generation of scientists may be better equipped with thorough knowledge and
      practice of HRE. This, we believe, would be one way of fighting the occurrence of
      research scandals, which have not yet abated significantly, especially those
      arising from negligence or inexcusable ignorance.
FAU - Munung, Nchangwi Syntia
AU  - Munung NS
AD  - University of Buea, Buea, Cameroon.
FAU - Tangwa, Godfrey B
AU  - Tangwa GB
FAU - Che, Chi Primus
AU  - Che CP
FAU - Vidal, Laurent
AU  - Vidal L
FAU - Ouwe-Missi-Oukem-Boyer, Odile
AU  - Ouwe-Missi-Oukem-Boyer O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120611
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Academic Dissertations as Topic
MH  - Acquired Immunodeficiency Syndrome/diagnosis/drug therapy
MH  - Cameroon
MH  - Clinical Trials as Topic/*ethics/methods
MH  - *Ethics, Research
MH  - *HIV Infections/diagnosis/drug therapy
MH  - Humans
MH  - Informed Consent/*ethics/statistics & numerical data
MH  - *Research Design
MH  - Retrospective Studies
MH  - Students, Health Occupations
MH  - *Students, Medical
PMC - PMC3470971
EDAT- 2012/06/13 06:00
MHDA- 2012/12/18 06:00
CRDT- 2012/06/13 06:00
PHST- 2011/11/18 00:00 [received]
PHST- 2012/05/14 00:00 [accepted]
PHST- 2012/06/13 06:00 [entrez]
PHST- 2012/06/13 06:00 [pubmed]
PHST- 2012/12/18 06:00 [medline]
AID - 1472-6939-13-12 [pii]
AID - 10.1186/1472-6939-13-12 [doi]
PST - epublish
SO  - BMC Med Ethics. 2012 Jun 11;13:12. doi: 10.1186/1472-6939-13-12.


PMID- 22685941
OWN - NLM
STAT- MEDLINE
DCOM- 20120710
LR  - 20161020
IS  - 0723-2276 (Print)
IS  - 0723-2276 (Linking)
VI  - 31
IP  - 5
DP  - 2012 May
TI  - [The question "when is the person dead?" German ethics counsel].
PG  - 211
FAU - Florian, Ulrike
AU  - Florian U
AD  - florian@ethikrat.org
LA  - ger
PT  - Journal Article
TT  - Die Frage "Wann ist ein Mensch tot?" Beschaftigte den Deutschen Ethikrat.
PL  - Germany
TA  - Kinderkrankenschwester
JT  - Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege
JID - 8305989
MH  - Adult
MH  - Brain Death/*diagnosis
MH  - Child
MH  - *Ethics Committees
MH  - Germany
MH  - Humans
MH  - Philosophy, Medical
MH  - Tissue and Organ Harvesting/*ethics/*nursing
MH  - Tissue and Organ Procurement/*ethics
EDAT- 2012/06/13 06:00
MHDA- 2012/07/11 06:00
CRDT- 2012/06/13 06:00
PHST- 2012/06/13 06:00 [entrez]
PHST- 2012/06/13 06:00 [pubmed]
PHST- 2012/07/11 06:00 [medline]
PST - ppublish
SO  - Kinderkrankenschwester. 2012 May;31(5):211.


PMID- 22685900
OWN - NLM
STAT- MEDLINE
DCOM- 20120703
LR  - 20120612
IS  - 0026-556X (Print)
IS  - 0026-556X (Linking)
VI  - 95
IP  - 4
DP  - 2012 Apr
TI  - Allocating resources during a crisis: you can't always get what you want.
PG  - 46-50
AB  - During a disaster or disease outbreak, health care providers may have to make
      difficult decisions about how to allocate scarce resources. A committee convened 
      by the Minnesota Department of Health has recently focused on this issue as part 
      of statewide disaster preparedness planning. This article presents the group's
      recommendation that health care facilities need to plan for shortages and
      introduces resources and strategies that can be used in planning. It also
      discusses ethical considerations that must be taken into account when shortages
      occur and decisions must be made about how to distribute equipment, supplies, or 
      medications in short supply.
FAU - Hick, John L
AU  - Hick JL
AD  - Hennepin County Medical Center, University of Minnesota, USA.
FAU - DeVries, Aaron S
AU  - DeVries AS
FAU - Fink-Kocken, Paula
AU  - Fink-Kocken P
FAU - Braun, Jane E
AU  - Braun JE
FAU - Marchetti, Judy
AU  - Marchetti J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Minn Med
JT  - Minnesota medicine
JID - 8000173
SB  - IM
MH  - Cooperative Behavior
MH  - Decision Support Techniques
MH  - Delivery of Health Care/ethics/organization & administration
MH  - Disaster Planning/*organization & administration
MH  - Ethics, Medical
MH  - Health Care Rationing/ethics/*organization & administration
MH  - Health Services Needs and Demand/organization & administration
MH  - Humans
MH  - Interdisciplinary Communication
MH  - Minnesota
MH  - Patient Care Team/ethics/organization & administration
EDAT- 2012/06/13 06:00
MHDA- 2012/07/04 06:00
CRDT- 2012/06/13 06:00
PHST- 2012/06/13 06:00 [entrez]
PHST- 2012/06/13 06:00 [pubmed]
PHST- 2012/07/04 06:00 [medline]
PST - ppublish
SO  - Minn Med. 2012 Apr;95(4):46-50.


PMID- 22685245
OWN - NLM
STAT- MEDLINE
DCOM- 20120807
LR  - 20171116
IS  - 1473-6810 (Electronic)
IS  - 1356-5524 (Linking)
VI  - 17
IP  - 3
DP  - 2012 Jun
TI  - For ethical, economic and scientific reasons, health-relevant degree theses must 
      be made publicly accessible.
PG  - 69-70
LID - 10.1136/ebmed-2012-100583 [doi]
FAU - Chalmers, Iain
AU  - Chalmers I
LA  - eng
PT  - Editorial
PL  - England
TA  - Evid Based Med
JT  - Evidence-based medicine
JID - 9608386
SB  - IM
MH  - *Academic Dissertations as Topic
MH  - *Evidence-Based Medicine
MH  - *Publishing
EDAT- 2012/06/12 06:00
MHDA- 2012/08/08 06:00
CRDT- 2012/06/12 06:00
PHST- 2012/06/12 06:00 [entrez]
PHST- 2012/06/12 06:00 [pubmed]
PHST- 2012/08/08 06:00 [medline]
AID - ebmed-2012-100583 [pii]
AID - 10.1136/ebmed-2012-100583 [doi]
PST - ppublish
SO  - Evid Based Med. 2012 Jun;17(3):69-70. doi: 10.1136/ebmed-2012-100583.


PMID- 22685225
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 3
DP  - 2012
TI  - Protocol for a population-based study of rheumatic heart disease prevalence and
      cardiovascular outcomes among schoolchildren in Nepal.
LID - 10.1136/bmjopen-2012-001320 [doi]
LID - e001320 [pii]
AB  - INTRODUCTION: Rheumatic heart disease (RHD) remains a major contributor to
      morbidity and mortality in developing countries. The reported prevalence rates of
      RHD are highly variable and mainly attributable to differences in the sensitivity
      of either clinical screening to detect advanced heart disease or
      echocardiographic evaluation where disease is diagnosed earlier across a
      continuous spectrum. The clinical significance of diagnosis of subclinical RHD by
      echocardiographic screening and early implementation of secondary prevention has 
      not been clearly established. METHODS AND ANALYSIS: The authors designed a
      cross-sectional survey to determine the prevalence of RHD in children from
      private and public schools between the age of 5 and 15 years in urban and rural
      areas of Eastern Nepal using both cardiac auscultation and echocardiographic
      evaluation. Children with RHD will be treated with secondary prevention and
      enrolled in a prospective cohort study. The authors will compare the prevalence
      rates by cardiac auscultation and echocardiography, determine risk factors
      associated with diagnosis and progression of RHD, investigate social and economic
      barriers for receiving adequate cardiac care and assess clinical outcomes with
      regular medical surveillance as a function of stage of disease at the time of
      diagnosis. Prospective clinical studies investigating the impact of secondary
      prevention for subclinical RHD on long-term clinical outcome will be of central
      relevance for future health resource utilisation in developing countries. ETHICS 
      AND DISSEMINATION: The study was considered ethically uncritical and was given an
      exempt status by the ethics committee at University of Bern, Switzerland. The
      study has been submitted to the National Nepal Health Research Council and was
      registered with http://www.ClinicalTrials.gov (NCT01550068). The study findings
      will be reported in peer-reviewed publications. CLINICALTRIALS.GOV IDENTIFIER:
      NCT01550068.
FAU - Pilgrim, Thomas
AU  - Pilgrim T
AD  - Department of Cardiology, Swiss Cardiovascular Center Bern, Bern University
      Hospital, Bern, Switzerland.
FAU - Kalesan, Bindu
AU  - Kalesan B
FAU - Karki, Prahlad
AU  - Karki P
FAU - Basnet, Anil
AU  - Basnet A
FAU - Meier, Bernhard
AU  - Meier B
FAU - Urban, Philip
AU  - Urban P
FAU - Shrestha, Nikesh Raj
AU  - Shrestha NR
LA  - eng
SI  - ClinicalTrials.gov/NCT01550068
PT  - Journal Article
DEP - 20120608
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3371575
EDAT- 2012/06/12 06:00
MHDA- 2012/06/12 06:01
CRDT- 2012/06/12 06:00
PHST- 2012/06/12 06:00 [entrez]
PHST- 2012/06/12 06:00 [pubmed]
PHST- 2012/06/12 06:01 [medline]
AID - bmjopen-2012-001320 [pii]
AID - 10.1136/bmjopen-2012-001320 [doi]
PST - epublish
SO  - BMJ Open. 2012 Jun 8;2(3). pii: bmjopen-2012-001320. doi:
      10.1136/bmjopen-2012-001320. Print 2012.


PMID- 22685224
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20220129
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 3
DP  - 2012
TI  - GaPP: a pilot randomised controlled trial of the efficacy of action of gabapentin
      for the management of chronic pelvic pain in women: study protocol.
LID - 10.1136/bmjopen-2012-001297 [doi]
LID - e001297 [pii]
AB  - INTRODUCTION: Chronic pelvic pain (CPP) affects >1 million UK women. Annual
      healthcare costs are estimated at > pound150 million. Proven interventions for
      CPP are limited, and treatment is often unsatisfactory. Gabapentin is
      increasingly prescribed due to reports of effectiveness in other chronic pain
      conditions, but there are insufficient data supporting value in CPP specifically.
      The mechanism by which gabapentin exerts its analgesic action is unknown. Given
      the prevalence and costs of CPP, the authors believe that a large, multicentre,
      placebo-controlled, double-blind randomised controlled trial to evaluate the
      efficacy of gabapentin in management of CPP is required. The focus of this study 
      is a pilot to inform planning of a future randomised controlled trial. METHODS
      AND ANALYSIS: The authors plan to perform a two-arm, parallel, randomised
      controlled pilot trial. The authors aim to recruit 60 women with CPP in NHS
      Lothian and NHS Grampian (UK) and randomise them to gabapentin or placebo.
      Response to treatment will be monitored by questionnaire compared at 0, 3 and 6
      months. The primary objective is to assess recruitment and retention rates. The
      secondary objectives are to determine the effectiveness and acceptability to
      participants of the proposed methods of recruitment, randomisation, drug
      treatments and assessment tools and to perform a pretrial cost-effectiveness
      assessment of treatment with gabapentin. ETHICS AND DISSEMINATION: Ethical
      approval has been obtained from the Scotland A Research Ethics Committee (LREC
      12/SS/0005). Data will be presented at international conferences and published in
      peer-reviewed journals. TRIAL REGISTRATION NUMBER: ISRCTN70960777.
FAU - Horne, Andrew W
AU  - Horne AW
AD  - MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK.
FAU - Critchley, Hilary O D
AU  - Critchley HO
FAU - Doust, Ann
AU  - Doust A
FAU - Fehr, Daniel
AU  - Fehr D
FAU - Wilson, John
AU  - Wilson J
FAU - Wu, Olivia
AU  - Wu O
FAU - Jack, S
AU  - Jack S
FAU - Porter, Maureen
AU  - Porter M
FAU - Lewis, Steff
AU  - Lewis S
FAU - Bhattacharya, Siladitya
AU  - Bhattacharya S
LA  - eng
GR  - CZH/4/688/CSO_/Chief Scientist Office/United Kingdom
GR  - G0802808/MRC_/Medical Research Council/United Kingdom
GR  - G1002033/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
DEP - 20120608
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3371581
EDAT- 2012/06/12 06:00
MHDA- 2012/06/12 06:01
CRDT- 2012/06/12 06:00
PHST- 2012/06/12 06:00 [entrez]
PHST- 2012/06/12 06:00 [pubmed]
PHST- 2012/06/12 06:01 [medline]
AID - bmjopen-2012-001297 [pii]
AID - 10.1136/bmjopen-2012-001297 [doi]
PST - epublish
SO  - BMJ Open. 2012 Jun 8;2(3). pii: bmjopen-2012-001297. doi:
      10.1136/bmjopen-2012-001297. Print 2012.


PMID- 22683151
OWN - NLM
STAT- MEDLINE
DCOM- 20121226
LR  - 20120803
IS  - 1472-6491 (Electronic)
IS  - 1472-6483 (Linking)
VI  - 25
IP  - 2
DP  - 2012 Aug
TI  - The clinical benefit and safety of current and future assisted reproductive
      technology.
PG  - 108-17
LID - 10.1016/j.rbmo.2012.04.009 [doi]
AB  - Since the first birth by IVF was achieved in 1978, the techniques involved in
      assisted reproductive technology have grown at an enormous rate. However, new
      technology has rarely been robustly validated before clinical use and developing 
      scientific understanding of the available techniques has done little to alter
      their use. Furthermore, there are inconsistencies in the available clinical
      studies and endpoints. The benefits of some technologies already established for 
      routine use are currently dubious and there are clear ethical concerns with
      providing them to patients when their scientific basis is not clear. As the
      uptake of assisted reproductive technology increases and newer technologies
      continue to push the boundaries of science, it is important to consider the
      clinical benefits and safety of all assisted reproductive technologies. This
      review will discuss aspects of some of the more recent techniques, including
      sperm DNA-damage tests, intracytoplasmic morphologically selected sperm
      injection, amino acid and metabolomics profiling, preimplantation genetic
      screening and time-lapse imaging, and those that may have substantial impacts on 
      the field of reproductive medicine in the future including artificial gametes,
      ovarian transplantation and gene therapy.
CI  - Copyright (c) 2012 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All
      rights reserved.
FAU - Brown, Rachel
AU  - Brown R
AD  - Division of Medicine, University College London, Gower Street, UK.
      rmjbreb@ucl.ac.uk
FAU - Harper, Joyce
AU  - Harper J
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120430
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
RN  - 0 (Amino Acids)
SB  - IM
MH  - Amino Acids/analysis
MH  - DNA Damage/*genetics
MH  - Genetic Testing/*methods/trends
MH  - Genetic Therapy/trends
MH  - Humans
MH  - In Situ Nick-End Labeling/methods
MH  - Metabolomics/*methods/trends
MH  - Reproductive Techniques, Assisted/*standards/*trends
MH  - Sperm Injections, Intracytoplasmic/*methods/trends
MH  - Time-Lapse Imaging/*methods/trends
EDAT- 2012/06/12 06:00
MHDA- 2012/12/27 06:00
CRDT- 2012/06/12 06:00
PHST- 2012/01/15 00:00 [received]
PHST- 2012/03/11 00:00 [revised]
PHST- 2012/04/18 00:00 [accepted]
PHST- 2012/06/12 06:00 [entrez]
PHST- 2012/06/12 06:00 [pubmed]
PHST- 2012/12/27 06:00 [medline]
AID - S1472-6483(12)00290-8 [pii]
AID - 10.1016/j.rbmo.2012.04.009 [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2012 Aug;25(2):108-17. doi: 10.1016/j.rbmo.2012.04.009.
      Epub 2012 Apr 30.


PMID- 22683148
OWN - NLM
STAT- MEDLINE
DCOM- 20121226
LR  - 20131121
IS  - 1472-6491 (Electronic)
IS  - 1472-6483 (Linking)
VI  - 25
IP  - 2
DP  - 2012 Aug
TI  - Hype or hope? Ethical and practical considerations with clinical research in
      women with diminished ovarian reserve.
PG  - 98-102
LID - 10.1016/j.rbmo.2012.04.003 [doi]
AB  - This communication suggests that investigations of treatments for women with
      diminished functional ovarian reserve (DOR) call for specific practical and
      ethical considerations, as women with DOR, because of limited remaining
      reproductive life spans, appropriately feel under time constraints. Another
      medical journal recently published an opinion piece on the use of
      dehydroepiandrosterone in women with DOR, raising important questions about what 
      approaches should be taken to develop best available evidence in such patients.
      Their manuscript offers an excellent opportunity to consider ethical and clinical
      aspects of study design in clinical circumstances where patients have little to
      lose but face the promise of considerable gains in clinical pregnancy chances if 
      effective treatments can be developed. This commentary concludes that, in such
      circumstances, common sense as well as ethical considerations support the
      introduction of new treatments into the clinical mainstream even in absence of
      prospectively randomized studies if lower levels of evidence are supportive of
      positive treatment effects.
CI  - Copyright (c) 2012 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All
      rights reserved.
FAU - Gleicher, Norbert
AU  - Gleicher N
FAU - Barad, David H
AU  - Barad DH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120421
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
RN  - 459AG36T1B (Dehydroepiandrosterone)
SB  - IM
CIN - Reprod Biomed Online. 2012 Aug;25(2):103-7. PMID: 22717246
MH  - Clinical Trials as Topic/*ethics
MH  - Dehydroepiandrosterone/*therapeutic use
MH  - Female
MH  - Humans
MH  - Practice Guidelines as Topic/*standards
MH  - Pregnancy
MH  - Primary Ovarian Insufficiency/*drug therapy
MH  - Reproductive Techniques, Assisted/*ethics
MH  - Research Design/*standards
MH  - Time Factors
EDAT- 2012/06/12 06:00
MHDA- 2012/12/27 06:00
CRDT- 2012/06/12 06:00
PHST- 2011/06/21 00:00 [received]
PHST- 2012/03/29 00:00 [revised]
PHST- 2012/04/03 00:00 [accepted]
PHST- 2012/06/12 06:00 [entrez]
PHST- 2012/06/12 06:00 [pubmed]
PHST- 2012/12/27 06:00 [medline]
AID - S1472-6483(12)00219-2 [pii]
AID - 10.1016/j.rbmo.2012.04.003 [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2012 Aug;25(2):98-102. doi: 10.1016/j.rbmo.2012.04.003.
      Epub 2012 Apr 21.


PMID- 22683145
OWN - NLM
STAT- MEDLINE
DCOM- 20121210
LR  - 20220408
IS  - 1578-1747 (Electronic)
IS  - 0211-139X (Linking)
VI  - 47
IP  - 4
DP  - 2012 Jul-Aug
TI  - [Polypharmacy in frail elderly patients: is deprescribing the answer?].
PG  - 162-7
LID - 10.1016/j.regg.2012.01.003 [doi]
AB  - Deprescribing is the process of reconstructing multiple medication use by review 
      and analysis and which concludes with dose modification, replacement or
      elimination of some drugs or adding others. Its development is intended to
      resolve tensions and contradictions between two sets of questions: 1/is life
      expectancy shorter than the time the drug takes to obtain a benefit?, and 2/are
      the goals of prescribing-deprescribing consistent with those of care? The
      validity of the rationale on deprescribing is based on scientific and ethical
      reasons. The usefulness and safety of many drugs that frail elderly or terminally
      ill takes is unknown, and other drugs may cause troublesome or severe side
      effects. Thus, in some cases their removal could be justified, being
      substantially safe doing so.
CI  - Copyright (c) 2012 SEGG. Published by Elsevier Espana. All rights reserved.
FAU - Gavilan-Moral, Enrique
AU  - Gavilan-Moral E
AD  - Servicio de Medicina de Familia, Laboratorio de Practicas Innovadoras en
      Polimedicacion y Salud, polimedicado.com, Plasencia, Espana.
      enrique.gavilan.moral@gmail.com
FAU - Villafaina-Barroso, Antonio
AU  - Villafaina-Barroso A
FAU - Jimenez-de Gracia, Laura
AU  - Jimenez-de Gracia L
FAU - Gomez Santana, Maria del Carmen
AU  - Gomez Santana Mdel C
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
TT  - Ancianos fragiles polimedicados: inverted question markes la deprescripcion de
      medicamentos la salida?
DEP - 20120608
PL  - Spain
TA  - Rev Esp Geriatr Gerontol
JT  - Revista espanola de geriatria y gerontologia
JID - 8009022
SB  - IM
MH  - Aged
MH  - Drug Prescriptions/*standards
MH  - *Frail Elderly
MH  - Humans
MH  - *Polypharmacy
MH  - Practice Guidelines as Topic
MH  - Public Health
EDAT- 2012/06/12 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/06/12 06:00
PHST- 2012/01/19 00:00 [received]
PHST- 2012/01/21 00:00 [accepted]
PHST- 2012/06/12 06:00 [entrez]
PHST- 2012/06/12 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - S0211-139X(12)00060-1 [pii]
AID - 10.1016/j.regg.2012.01.003 [doi]
PST - ppublish
SO  - Rev Esp Geriatr Gerontol. 2012 Jul-Aug;47(4):162-7. doi:
      10.1016/j.regg.2012.01.003. Epub 2012 Jun 8.


PMID- 22682762
OWN - NLM
STAT- MEDLINE
DCOM- 20121126
LR  - 20120709
IS  - 1872-6054 (Electronic)
IS  - 0168-8510 (Linking)
VI  - 106
IP  - 3
DP  - 2012 Aug
TI  - Sale strategies of pharmaceutical companies in a "pharmerging" country: the
      problems will not improve if the gaps remain.
PG  - 225-32
LID - 10.1016/j.healthpol.2012.05.006 [doi]
AB  - OBJECTIVE: This study aimed to examine the types of sales strategies used by
      pharmaceutical companies in a "pharmerging" market and to gain insight into the
      ways of avoiding the negative effects of these strategies. METHOD: In-depth
      interviews were conducted with 22 physicians and company employees in the six
      largest cities of Turkey. The interviews were analyzed using content analysis.
      RESULTS: Various sales strategies, both legal and illegal, are universally
      applied. These methods target prescribers, patients, pharmacists, and society in 
      general. Different types of companies, organizations, professionals, and science 
      and ethical principles are used as means. Companies intervene immediately to
      prevent developments that may decrease sales, and exploit the educational and
      infrastructural needs. In contrast, physicians are overconfident about the
      effects of marketing and insufficiently educated on how to cope with the
      strategies and the drugs on the market, which make them vulnerable. Under these
      conditions, along with worldwide competition and economic volatility, policies
      that aim to set frameworks for pharmaceutical relationships have failed.
      CONCLUSION: Interventions are crucial, including instituting a national drug
      policy, minimizing the exposure to marketing, and addressing the educational and 
      infrastructural needs of the prescribers. Without these interventions, gaps will 
      continue to be exploited by companies for their own advantage, and the problems
      related to marketing will persist.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Civaner, Murat
AU  - Civaner M
AD  - Uludag University School of Medicine, Department of Medical Ethics, 16059,
      Gorukle, Bursa, Turkey. mcivaner@gmail.com
LA  - eng
PT  - Journal Article
DEP - 20120607
PL  - Ireland
TA  - Health Policy
JT  - Health policy (Amsterdam, Netherlands)
JID - 8409431
MH  - *Drug Industry
MH  - Ethics, Medical
MH  - Humans
MH  - Marketing/*methods
MH  - Qualitative Research
MH  - Turkey
EDAT- 2012/06/12 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/06/12 06:00
PHST- 2011/05/29 00:00 [received]
PHST- 2012/05/08 00:00 [revised]
PHST- 2012/05/23 00:00 [accepted]
PHST- 2012/06/12 06:00 [entrez]
PHST- 2012/06/12 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - S0168-8510(12)00150-9 [pii]
AID - 10.1016/j.healthpol.2012.05.006 [doi]
PST - ppublish
SO  - Health Policy. 2012 Aug;106(3):225-32. doi: 10.1016/j.healthpol.2012.05.006. Epub
      2012 Jun 7.


PMID- 22682707
OWN - NLM
STAT- MEDLINE
DCOM- 20121018
LR  - 20120611
IS  - 1873-2518 (Electronic)
IS  - 0264-410X (Linking)
VI  - 30
IP  - 30
DP  - 2012 Jun 22
TI  - Measles vaccination in health care personnel: mandates, ethics, and patient
      safety.
PG  - 4407-8
LID - 10.1016/j.vaccine.2012.05.015 [doi]
FAU - Wicker, Sabine
AU  - Wicker S
FAU - Poland, Gregory A
AU  - Poland GA
LA  - eng
PT  - Editorial
PL  - Netherlands
TA  - Vaccine
JT  - Vaccine
JID - 8406899
RN  - 0 (Measles Vaccine)
SB  - IM
MH  - Cross Infection/prevention & control
MH  - *Health Personnel
MH  - Health Policy
MH  - Humans
MH  - Infectious Disease Transmission, Professional-to-Patient/prevention & control
MH  - Measles/*prevention & control
MH  - Measles Vaccine/administration & dosage
MH  - *Patient Safety
MH  - Vaccination/*ethics/*standards
EDAT- 2012/06/12 06:00
MHDA- 2012/10/19 06:00
CRDT- 2012/06/12 06:00
PHST- 2012/05/10 00:00 [received]
PHST- 2012/05/11 00:00 [accepted]
PHST- 2012/06/12 06:00 [entrez]
PHST- 2012/06/12 06:00 [pubmed]
PHST- 2012/10/19 06:00 [medline]
AID - S0264-410X(12)00707-4 [pii]
AID - 10.1016/j.vaccine.2012.05.015 [doi]
PST - ppublish
SO  - Vaccine. 2012 Jun 22;30(30):4407-8. doi: 10.1016/j.vaccine.2012.05.015.


PMID- 22682504
OWN - NLM
STAT- MEDLINE
DCOM- 20130107
LR  - 20211203
IS  - 1472-6963 (Electronic)
IS  - 1472-6963 (Linking)
VI  - 12
DP  - 2012 Jun 10
TI  - Acceptability of participatory social network analysis for problem-solving in
      Australian Aboriginal health service partnerships.
PG  - 152
LID - 10.1186/1472-6963-12-152 [doi]
AB  - BACKGROUND: While participatory social network analysis can help health service
      partnerships to solve problems, little is known about its acceptability in
      cross-cultural settings. We conducted two case studies of chronic illness service
      partnerships in 2007 and 2008 to determine whether participatory research
      incorporating social network analysis is acceptable for problem-solving in
      Australian Aboriginal health service delivery. METHODS: Local research groups
      comprising 13-19 partnership staff, policy officers and community members were
      established at each of two sites to guide the research and to reflect and act on 
      the findings. Network and work practice surveys were conducted with 42 staff, and
      the results were fed back to the research groups. At the end of the project, 19
      informants at the two sites were interviewed, and the researchers conducted
      critical reflection. The effectiveness and acceptability of the participatory
      social network method were determined quantitatively and qualitatively. RESULTS: 
      Participants in both local research groups considered that the network survey had
      accurately described the links between workers related to the exchange of
      clinical and cultural information, team care relationships, involvement in
      service management and planning and involvement in policy development. This
      revealed the function of the teams and the roles of workers in each partnership. 
      Aboriginal workers had a high number of direct links in the exchange of cultural 
      information, illustrating their role as the cultural resource, whereas they had
      fewer direct links with other network members on clinical information exchange
      and team care. The problem of their current and future roles was discussed inside
      and outside the local research groups. According to the interview informants the 
      participatory network analysis had opened the way for problem-solving by "putting
      issues on the table". While there were confronting and ethically challenging
      aspects, these informants considered that with flexibility of data collection to 
      account for the preferences of Aboriginal members, then the method was
      appropriate in cross-cultural contexts for the difficult discussions that are
      needed to improve partnerships. CONCLUSION: Critical reflection showed that the
      preconditions for difficult discussions are, first, that partners have the
      capacity to engage in such discussions, second, that partners assess whether the 
      effort required for these discussions is balanced by the benefits they gain from 
      the partnership, and, third, that "boundary spanning" staff can facilitate
      commitment to partnership goals.
FAU - Fuller, Jeffrey
AU  - Fuller J
AD  - School of Nursing & Midwifery, Flinders University, GPO Box 2100, Adelaide, SA
      5001, Australia. jeffrey.fuller@flinders.edu.au
FAU - Hermeston, Wendy
AU  - Hermeston W
FAU - Passey, Megan
AU  - Passey M
FAU - Fallon, Tony
AU  - Fallon T
FAU - Muyambi, Kuda
AU  - Muyambi K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120610
PL  - England
TA  - BMC Health Serv Res
JT  - BMC health services research
JID - 101088677
SB  - IM
MH  - Australia
MH  - Capacity Building
MH  - *Community-Based Participatory Research
MH  - Cross-Cultural Comparison
MH  - Health Services, Indigenous
MH  - Humans
MH  - Native Hawaiian or Other Pacific Islander
MH  - Organizational Case Studies
MH  - *Problem Solving
MH  - *Social Networking
MH  - Surveys and Questionnaires
PMC - PMC3472193
EDAT- 2012/06/12 06:00
MHDA- 2013/01/08 06:00
CRDT- 2012/06/12 06:00
PHST- 2011/12/02 00:00 [received]
PHST- 2012/04/20 00:00 [accepted]
PHST- 2012/06/12 06:00 [entrez]
PHST- 2012/06/12 06:00 [pubmed]
PHST- 2013/01/08 06:00 [medline]
AID - 1472-6963-12-152 [pii]
AID - 10.1186/1472-6963-12-152 [doi]
PST - epublish
SO  - BMC Health Serv Res. 2012 Jun 10;12:152. doi: 10.1186/1472-6963-12-152.


PMID- 22682069
OWN - NLM
STAT- MEDLINE
DCOM- 20121221
LR  - 20220409
IS  - 1471-2431 (Electronic)
IS  - 1471-2431 (Linking)
VI  - 12
DP  - 2012 Jun 8
TI  - Relational development in children with cleft lip and palate: influence of the
      waiting period prior to the first surgical intervention and parental
      psychological perceptions of the abnormality.
PG  - 65
LID - 10.1186/1471-2431-12-65 [doi]
AB  - BACKGROUND: The birth of a child with a cleft lip, whether or not in association 
      with a cleft palate, is a traumatic event for parents. This prospective,
      multidisciplinary and multi-centre study aims to explore the perceptions and
      feelings of parents in the year following the birth of their child, and to
      analyse parent-child relationships. Four inclusion centres have been selected,
      differing as to the date of the first surgical intervention, between birth and
      six months. The aim is to compare results, also distinguishing the subgroups of
      parents who were given the diagnosis in utero and those who were not.
      METHODS/DESIGN: The main hypothesis is that the longer the time-lapse before the 
      first surgical intervention, the more likely are the psychological perceptions of
      the parents to affect the harmonious development of their child. Parents and
      children are seen twice, when the child is 4 months (T0) and when the child is
      one year old (T1). At these two times, the psychological state of the child and
      his/her relational abilities are assessed by a specially trained professional,
      and self-administered questionnaires measuring factors liable to affect
      child-parent relationships are issued to the parents. The Alarme Detresse BeBe
      score for the child and the Parenting Stress Index score for the parents,
      measured when the child reaches one year, will be used as the main criteria to
      compare children with early surgery to children with late surgery, and those
      where the diagnosis was obtained prior to birth with those receiving it at birth.
      DISCUSSION: The mental and psychological dimensions relating to the abnormality
      and its correction will be analysed for the parents (the importance of prenatal
      diagnosis, relational development with the child, self-image, quality of life)
      and also, for the first time, for the child (distress, withdrawal). In an ethical
      perspective, the different time lapses until surgery in the different protocols
      and their effects will be analysed, so as to serve as a reference for improving
      the quality of information during the waiting period, and the quality of support 
      provided for parents and children by the healthcare team before the first
      surgical intervention. TRIAL REGISTRATION: ClinicalTrials.gov Identifier:
      NCT00993993.
FAU - Grollemund, Bruno
AU  - Grollemund B
AD  - Departement d'Orthopedie Dento-Faciale, Pole de medecine et chirurgie
      buccodentaires, Hospices civils, Place de l'Hopital 1, Strasbourg 67000, France. 
      bruno.grollemund@gmail.com
FAU - Guedeney, Antoine
AU  - Guedeney A
FAU - Vazquez, Marie-Paule
AU  - Vazquez MP
FAU - Picard, Arnaud
AU  - Picard A
FAU - Soupre, Veronique
AU  - Soupre V
FAU - Pellerin, Philippe
AU  - Pellerin P
FAU - Simon, Etienne
AU  - Simon E
FAU - Velten, Michel
AU  - Velten M
FAU - Dissaux, Caroline
AU  - Dissaux C
FAU - Kauffmann, Isabelle
AU  - Kauffmann I
FAU - Bruant-Rodier, Catherine
AU  - Bruant-Rodier C
FAU - Danion-Grilliat, Anne
AU  - Danion-Grilliat A
LA  - eng
SI  - ClinicalTrials.gov/NCT00993993
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20120608
PL  - England
TA  - BMC Pediatr
JT  - BMC pediatrics
JID - 100967804
SB  - IM
MH  - *Attitude to Health
MH  - Cleft Lip/complications/diagnosis/*psychology/surgery
MH  - Cleft Palate/complications/diagnosis/*psychology/surgery
MH  - Clinical Protocols
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Multivariate Analysis
MH  - *Parent-Child Relations
MH  - Parenting/psychology
MH  - Parents/*psychology
MH  - Pregnancy
MH  - Prenatal Diagnosis
MH  - Psychological Tests
MH  - *Reconstructive Surgical Procedures
MH  - Stress, Psychological
MH  - Time Factors
MH  - *Waiting Lists
PMC - PMC3436730
EDAT- 2012/06/12 06:00
MHDA- 2012/12/22 06:00
CRDT- 2012/06/12 06:00
PHST- 2012/05/07 00:00 [received]
PHST- 2012/05/29 00:00 [accepted]
PHST- 2012/06/12 06:00 [entrez]
PHST- 2012/06/12 06:00 [pubmed]
PHST- 2012/12/22 06:00 [medline]
AID - 1471-2431-12-65 [pii]
AID - 10.1186/1471-2431-12-65 [doi]
PST - epublish
SO  - BMC Pediatr. 2012 Jun 8;12:65. doi: 10.1186/1471-2431-12-65.


PMID- 22681971
OWN - NLM
STAT- MEDLINE
DCOM- 20121030
LR  - 20220410
IS  - 1532-3374 (Electronic)
IS  - 0959-289X (Linking)
VI  - 21
IP  - 3
DP  - 2012 Jul
TI  - Efficacy of dexmedetomidine in suppressing cardiovascular and hormonal responses 
      to general anaesthesia for caesarean delivery: a dose-response study.
PG  - 222-9
LID - 10.1016/j.ijoa.2012.04.006 [doi]
AB  - BACKGROUND: Preoperative dexmedetomidine administration blunts haemodynamic and
      hormonal responses to tracheal intubation and reduces anaesthetic requirements.
      We hypothesized that dexmedetomidine would reduce the maternal haemodynamic and
      hormonal responses to elective caesarean delivery without harmful neonatal
      effects. METHODS: After ethical approval, 68 parturients scheduled for elective
      caesarean delivery under general anaesthesia were randomly allocated to receive
      either placebo, or 0.2, 0.4 or 0.6 mug/kg/h intravenous dexmedetomidine (n=17 per
      group) 20 min before induction. Anaesthesia was induced using a rapid-sequence
      technique with propofol and suxamethonium, and was maintained with 0.5-0.75
      minimum alveolar concentration sevoflurane. Changes in maternal heart rate, mean 
      blood pressure, minimum alveolar concentration sevoflurane, uterine tone, serum
      cortisol level, and Apgar scores, Neurologic Adaptive Capacity Scores and
      acid-base status were recorded. RESULTS: After induction, patients receiving
      dexmedetomidine had smaller increases in heart rate (P<0.001) than those in the
      placebo group. Patients who received 0.4 and 0.6 mug/kg/h infusions of
      dexmedetomidine showed slower heart rates (-21.5% and -36%, respectively;
      P<0.001), lower mean blood pressures (-17% and -25%, respectively; P<0.001),
      sevoflurane minimum alveolar concentrations (-40% and -44.5%, respectively;
      P<0.001) and serum cortisol levels (-27% and -34.6%, respectively; P<0.001) and
      higher sedation scores for the first 15 min after extubation and greater uterine 
      tone (P<0.002). Apgar scores, NACS and acid-base status were similar in the four 
      groups. CONCLUSION: Preoperative administration of dexmedetomidine 0.4 and 0.6
      mug/kg/h is effective in attenuating the maternal haemodynamic and hormonal
      responses to caesarean delivery under sevoflurane anaesthesia without adverse
      neonatal effects.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - El-Tahan, M R
AU  - El-Tahan MR
AD  - Department of Anesthesia and Surgical ICU, College of Medicine, University of
      Dammam, Al Khubar, Saudi Arabia mohamedrefaateltahan@yahoo.com
FAU - Mowafi, H A
AU  - Mowafi HA
FAU - Al Sheikh, I H
AU  - Al Sheikh IH
FAU - Khidr, A M
AU  - Khidr AM
FAU - Al-Juhaiman, R A
AU  - Al-Juhaiman RA
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20120607
PL  - Netherlands
TA  - Int J Obstet Anesth
JT  - International journal of obstetric anesthesia
JID - 9200430
RN  - 0 (Adrenergic alpha-2 Receptor Agonists)
RN  - 67VB76HONO (Dexmedetomidine)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adrenergic alpha-2 Receptor Agonists/*pharmacology
MH  - *Anesthesia, General
MH  - *Anesthesia, Obstetrical
MH  - Blood Pressure/*drug effects
MH  - *Cesarean Section
MH  - Dexmedetomidine/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Double-Blind Method
MH  - Female
MH  - Heart Rate/*drug effects
MH  - Humans
MH  - Hydrocortisone/*blood
MH  - Pregnancy
MH  - Prospective Studies
EDAT- 2012/06/12 06:00
MHDA- 2012/10/31 06:00
CRDT- 2012/06/12 06:00
PHST- 2012/01/16 00:00 [received]
PHST- 2012/04/23 00:00 [revised]
PHST- 2012/04/24 00:00 [accepted]
PHST- 2012/06/12 06:00 [entrez]
PHST- 2012/06/12 06:00 [pubmed]
PHST- 2012/10/31 06:00 [medline]
AID - S0959-289X(12)00051-9 [pii]
AID - 10.1016/j.ijoa.2012.04.006 [doi]
PST - ppublish
SO  - Int J Obstet Anesth. 2012 Jul;21(3):222-9. doi: 10.1016/j.ijoa.2012.04.006. Epub 
      2012 Jun 7.


PMID- 22681677
OWN - NLM
STAT- MEDLINE
DCOM- 20141124
LR  - 20140304
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 28
IP  - 3
DP  - 2014 Mar
TI  - Equity under the knife: justice and evidence in surgery.
PG  - 119-26
LID - 10.1111/j.1467-8519.2012.01980.x [doi]
AB  - Surgery is an increasingly common and expensive mode of medical intervention. The
      ethical dimensions of the surgeon-patient relationship, including respect for
      personal autonomy and informed consent, are much discussed; but broader equity
      issues have not received the same attention. This paper extends the understanding
      of surgical ethics by considering the nature of evidence in surgery and its
      relationship to a just provision of healthcare for individuals and their
      populations.
CI  - (c) 2012 John Wiley & Sons Ltd.
FAU - Rogers, Wendy
AU  - Rogers W
AD  - Macquarie University.
FAU - Degeling, Christopher
AU  - Degeling C
FAU - Townley, Cynthia
AU  - Townley C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120610
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - Clinical Trials as Topic/ethics
MH  - Ethics, Medical
MH  - Evidence-Based Medicine/*ethics
MH  - Humans
MH  - Patient Selection
MH  - Physician-Patient Relations/*ethics
MH  - Primary Health Care
MH  - *Social Justice
MH  - Surgical Procedures, Operative/*ethics
MH  - *Treatment Outcome
OTO - NOTNLM
OT  - equity
OT  - evidence
OT  - health technology assessment
OT  - justice
OT  - public health ethics
OT  - surgery
EDAT- 2012/06/12 06:00
MHDA- 2014/12/15 06:00
CRDT- 2012/06/12 06:00
PHST- 2012/06/12 06:00 [entrez]
PHST- 2012/06/12 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - 10.1111/j.1467-8519.2012.01980.x [doi]
PST - ppublish
SO  - Bioethics. 2014 Mar;28(3):119-26. doi: 10.1111/j.1467-8519.2012.01980.x. Epub
      2012 Jun 10.


PMID- 22681655
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20131106
IS  - 1744-7682 (Electronic)
IS  - 1471-2598 (Linking)
VI  - 12
IP  - 8
DP  - 2012 Aug
TI  - Human cord blood applications in cell therapy: looking back and look ahead.
PG  - 1059-66
LID - 10.1517/14712598.2012.691161 [doi]
AB  - INTRODUCTION: Human umbilical cord blood (UCB) has been used as a reliable source
      of stem cells for blood-borne diseases and disorders. Recent advances in cell
      reprogramming technology to produce induced pluripotent stem (iPS) cells, which
      can be differentiated to multiple adult cell types, has further expanded the
      potential of cord blood cell therapy for treatment of non-blood-borne diseases.
      However, in order to harness this breakthrough technology and to provide
      clinical-grade cells for the patient, standardization of iPS production and
      differentiation, and good manufacturing practice (GMP) need to be employed. AREAS
      COVERED: UCB is an ethical source of stem cells and has been used to treat
      diseases including leukemia, cancer and blood disorders. The development of iPS
      cell technology could potentially greatly increase the application of cord blood 
      cells as a treatment for a broader range of diseases, UCB-iPS banks could,
      therefore, be a valuable complementary source of clinical-grade cells for cell
      therapy. The current applicability of GMP to UCB and UCB-iPS cell-based cell
      therapy will be discussed. EXPERT OPINION: Although cord blood stem cell
      therapies have been practiced for decades, UCB-iPS cell therapies are a new
      innovation currently in development. Successful clinical applications of such
      novel cell therapies will depend on the production of GMP-compliant cells and the
      establishment of cell banks.
FAU - Zhou, Hongyan
AU  - Zhou H
AD  - New York Stem Cell Foundation, NY, USA.
FAU - Chang, Stephen
AU  - Chang S
FAU - Rao, Mahendra
AU  - Rao M
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20120611
PL  - England
TA  - Expert Opin Biol Ther
JT  - Expert opinion on biological therapy
JID - 101125414
SB  - IM
MH  - Biological Specimen Banks/history/standards/*trends
MH  - Biotechnology/history/standards/*trends
MH  - Cell Differentiation
MH  - Cell Proliferation
MH  - Cord Blood Stem Cell Transplantation/history/standards/*trends
MH  - Forecasting
MH  - Guidelines as Topic
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*transplantation
MH  - Regeneration
MH  - Regenerative Medicine/history/standards/*trends
EDAT- 2012/06/12 06:00
MHDA- 2012/11/14 06:00
CRDT- 2012/06/12 06:00
PHST- 2012/06/12 06:00 [entrez]
PHST- 2012/06/12 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
AID - 10.1517/14712598.2012.691161 [doi]
PST - ppublish
SO  - Expert Opin Biol Ther. 2012 Aug;12(8):1059-66. doi: 10.1517/14712598.2012.691161.
      Epub 2012 Jun 11.


PMID- 22681632
OWN - NLM
STAT- MEDLINE
DCOM- 20141124
LR  - 20140304
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 28
IP  - 3
DP  - 2014 Mar
TI  - Are phase 1 trials therapeutic? Risk, ethics, and division of labor.
PG  - 138-46
LID - 10.1111/j.1467-8519.2012.01979.x [doi]
AB  - Despite their crucial role in the translation of pre-clinical research into new
      clinical applications, phase 1 trials involving patients continue to prompt
      ethical debate. At the heart of the controversy is the question of whether risks 
      of administering experimental drugs are therapeutically justified. We suggest
      that prior attempts to address this question have been muddled, in part because
      it cannot be answered adequately without first attending to the way labor is
      divided in managing risk in clinical trials. In what follows, we approach the
      question of therapeutic justification for phase 1 trials from the viewpoint of
      five different stakeholders: the drug regulatory authority, the IRB, the clinical
      investigator, the referring physician, and the patient. Our analysis shows that
      the question of therapeutic justification actually raises multiple questions
      corresponding to the roles and responsibilities of the different stakeholders
      involved. By attending to these contextual differences, we provide more coherent 
      guidance for the ethical negotiation of risk in phase 1 trials involving
      patients. We close by discussing the implications of our argument for various
      perennial controversies in phase 1 trial practice.
CI  - (c) 2012 John Wiley & Sons Ltd.
FAU - Anderson, James A
AU  - Anderson JA
AD  - University of British Columbia McGill University.
FAU - Kimmelman, Jonathan
AU  - Kimmelman J
LA  - eng
GR  - EOG 102824/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120610
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - *Antineoplastic Agents/administration & dosage/adverse effects/pharmacology
MH  - Clinical Trials, Phase I as Topic/*ethics
MH  - Comprehension
MH  - *Decision Making
MH  - Ethics Committees, Research
MH  - Ethics, Research
MH  - Human Experimentation/*ethics
MH  - Humans
MH  - Information Dissemination
MH  - *Neoplasms/drug therapy
MH  - Patient Advocacy
MH  - Patients
MH  - Physician-Patient Relations/ethics
MH  - Referral and Consultation
MH  - Research Personnel/*ethics/standards
MH  - Risk
MH  - Societies, Medical
MH  - United States
MH  - United States Food and Drug Administration
OTO - NOTNLM
OT  - clinical research
OT  - ethics
OT  - phase 1 trials
OT  - risk
OT  - therapy
EDAT- 2012/06/12 06:00
MHDA- 2014/12/15 06:00
CRDT- 2012/06/12 06:00
PHST- 2012/06/12 06:00 [entrez]
PHST- 2012/06/12 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - 10.1111/j.1467-8519.2012.01979.x [doi]
PST - ppublish
SO  - Bioethics. 2014 Mar;28(3):138-46. doi: 10.1111/j.1467-8519.2012.01979.x. Epub
      2012 Jun 10.


PMID- 22681541
OWN - NLM
STAT- MEDLINE
DCOM- 20121207
LR  - 20131121
IS  - 1466-447X (Electronic)
IS  - 0264-0414 (Linking)
VI  - 30
IP  - 11
DP  - 2012
TI  - Human genetic variation: new challenges and opportunities for doping control.
PG  - 1117-29
LID - 10.1080/02640414.2012.692480 [doi]
AB  - Sport celebrates differences in competitors that lead to the often razor-thin
      margins between victory and defeat. The source of this variation is the
      interaction between the environment in which the athletes develop and compete and
      their genetic make-up. However, a darker side of sports may also be genetically
      influenced: some anti-doping tests are affected by the athlete's genotype.
      Genetic variation is an issue that anti-doping authorities must address as more
      is learned about the interaction between genotype and the responses to prohibited
      practices. To differentiate between naturally occurring deviations in indirect
      blood and urine markers from those potentially caused by doping, the
      "biological-passport" program uses intra-individual variability rather than
      population values to establish an athlete's expected physiological range. The
      next step in "personalized" doping control may be the inclusion of genetic data, 
      both for the purposes of documenting an athlete's responses to doping agents and 
      doping-control assays as well facilitating athlete and sample identification.
      Such applications could benefit "clean" athletes but will come at the expense of 
      risks to privacy. This article reviews the instances where genetics has
      intersected with doping control, and briefly discusses the potential role, and
      ethical implications, of genotyping in the struggle to eliminate illicit
      ergogenic practices.
FAU - Schneider, Angela J
AU  - Schneider AJ
AD  - The International Centre for Olympic Studies, The University of Western Ontario, 
      London, Ontario, Canada.
FAU - Fedoruk, Matthew N
AU  - Fedoruk MN
FAU - Rupert, Jim L
AU  - Rupert JL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120611
PL  - England
TA  - J Sports Sci
JT  - Journal of sports sciences
JID - 8405364
RN  - 0 (MSTN protein, human)
RN  - 0 (Myostatin)
RN  - 0 (Receptors, Adrenergic)
RN  - 0 (Receptors, Erythropoietin)
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - Athletes/legislation & jurisprudence
MH  - Athletic Performance/ethics/legislation & jurisprudence
MH  - Chimera
MH  - Doping in Sports/*ethics/legislation & jurisprudence/methods
MH  - Female
MH  - *Genetic Variation
MH  - Genotyping Techniques/ethics
MH  - Hematocrit
MH  - Humans
MH  - Male
MH  - Myostatin/genetics/physiology
MH  - Privacy/legislation & jurisprudence
MH  - Receptors, Adrenergic/drug effects
MH  - Receptors, Erythropoietin/genetics
MH  - Testosterone/blood/pharmacology/urine
EDAT- 2012/06/12 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/06/12 06:00
PHST- 2012/06/12 06:00 [entrez]
PHST- 2012/06/12 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - 10.1080/02640414.2012.692480 [doi]
PST - ppublish
SO  - J Sports Sci. 2012;30(11):1117-29. doi: 10.1080/02640414.2012.692480. Epub 2012
      Jun 11.


PMID- 22679396
OWN - NLM
STAT- MEDLINE
DCOM- 20121119
LR  - 20211021
IS  - 1549-1676 (Electronic)
IS  - 1549-1277 (Linking)
VI  - 9
IP  - 6
DP  - 2012
TI  - Why human health and health ethics must be central to climate change
      deliberations.
PG  - e1001229
LID - 10.1371/journal.pmed.1001229 [doi]
AB  - Jerome Singh argues that health ethics principles must be afforded equal status
      to economics principles in climate change deliberations, and that the health
      community must play more of a leadership role.
FAU - Singh, Jerome Amir
AU  - Singh JA
AD  - Centre for the AIDS Programme of Research in South Africa, University of
      Kwazulu-Natal, Durban, South Africa. singhj9@ukzn.ac.za
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120605
PL  - United States
TA  - PLoS Med
JT  - PLoS medicine
JID - 101231360
SB  - IM
MH  - *Climate Change
MH  - Decision Making
MH  - Humans
MH  - Public Health/*ethics
PMC - PMC3367987
EDAT- 2012/06/09 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/06/09 06:00
PHST- 2012/06/09 06:00 [entrez]
PHST- 2012/06/09 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1371/journal.pmed.1001229 [doi]
AID - PMEDICINE-D-11-02534 [pii]
PST - ppublish
SO  - PLoS Med. 2012;9(6):e1001229. doi: 10.1371/journal.pmed.1001229. Epub 2012 Jun 5.


PMID- 22679216
OWN - NLM
STAT- MEDLINE
DCOM- 20121205
LR  - 20120706
IS  - 1440-1665 (Electronic)
IS  - 1039-8562 (Linking)
VI  - 20
IP  - 3
DP  - 2012 Jun
TI  - Psychiatry and online social media: potential, pitfalls and ethical guidelines
      for psychiatrists and trainees.
PG  - 181-7
LID - 10.1177/1039856212447881 [doi]
AB  - OBJECTIVE: This paper proposes ethical guidelines for psychiatrists and
      psychiatry trainees when interacting with social media. METHODS: A three-stage
      process was followed in the development of these guidelines. A literature review 
      provided situations and possible broad rules as to how social media could be
      ethically engaged. A roundtable discussion by a panel of invited psychiatrists,
      psychiatry trainees, psychologists, e-health practitioners, lawyers and consumers
      was held to discuss the situations and to better formulate the ethical principles
      upon which psychiatrists could act. These vignettes and principles were then
      broadly discussed at a seminar held at the 2011 RANZCP Congress. Finally, this
      paper was circulated to the original invitees for final comment. RESULTS: A set
      of recommendations for working with social media were developed. CONCLUSIONS: The
      new social media provides important avenues for communication, education and
      treatment. These avenues pose ethical and practical dilemmas that can be resolved
      by the application of established ethical principles. Practical recommendations
      for navigating social media are proposed.
FAU - Frankish, Katherine
AU  - Frankish K
AD  - Redbank House, Westmead Hospital, Wentworthville, NSW, Australia.
      katiefrankish@hotmail.com
FAU - Ryan, Christopher
AU  - Ryan C
FAU - Harris, Anthony
AU  - Harris A
LA  - eng
PT  - Journal Article
DEP - 20120607
PL  - England
TA  - Australas Psychiatry
JT  - Australasian psychiatry : bulletin of Royal Australian and New Zealand College of
      Psychiatrists
JID - 9613603
SB  - IM
MH  - Confidentiality/ethics
MH  - Ethics, Medical/*education
MH  - Guidelines as Topic
MH  - Humans
MH  - Physician-Patient Relations/ethics
MH  - Privacy
MH  - Psychiatry/education/*ethics
MH  - Social Media/*ethics/*standards
EDAT- 2012/06/09 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/06/09 06:00
PHST- 2012/06/09 06:00 [entrez]
PHST- 2012/06/09 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 1039856212447881 [pii]
AID - 10.1177/1039856212447881 [doi]
PST - ppublish
SO  - Australas Psychiatry. 2012 Jun;20(3):181-7. doi: 10.1177/1039856212447881. Epub
      2012 Jun 7.


PMID- 22679104
OWN - NLM
STAT- MEDLINE
DCOM- 20130812
LR  - 20181202
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 6
DP  - 2013 Jun
TI  - End-of-life decision making in Taiwan: healthcare practice is rooted in local
      culture and laws that should be adjusted to patients' best interests.
PG  - 387-8
LID - 10.1136/medethics-2012-100760 [doi]
AB  - The observed Taiwanese neonatal professionals' more conservative attitudes than
      their worldwide colleagues towards end-of-life (EOL) decision making may stem
      from cultural attitudes toward death in children and concerns about medicolegal
      liability. Healthcare practice is rooted in local culture and laws; however that 
      should be adjusted to patients' best interests. Improving Taiwanese neonatal
      professionals' knowledge and competence in EOL care may minimize ethical
      dilemmas, allow appropriate EOL care decision making, avoid infants' suffering,
      and ease parents' bereavement grief.
FAU - Tang, Siew Tzuh
AU  - Tang ST
AD  - School of Nursing, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan,
      Tao-Yuan 333, Taiwan. sttang@mail.cgu.edu.tw
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20120607
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
CON - J Med Ethics. 2013 Jun;39(6):382-6. PMID: 22562946
MH  - *Attitude of Health Personnel
MH  - *Attitude to Death
MH  - Decision Making/*ethics
MH  - Female
MH  - Humans
MH  - Male
MH  - Medical Staff, Hospital/*ethics
MH  - Neonatology/*ethics
MH  - Nursing Staff, Hospital/*ethics
MH  - Resuscitation Orders/*ethics
MH  - Terminal Care/*ethics
OTO - NOTNLM
OT  - Care of the dying patient
OT  - care of dying minors
OT  - elderly and terminally ill
EDAT- 2012/06/09 06:00
MHDA- 2013/08/13 06:00
CRDT- 2012/06/09 06:00
PHST- 2012/06/09 06:00 [entrez]
PHST- 2012/06/09 06:00 [pubmed]
PHST- 2013/08/13 06:00 [medline]
AID - medethics-2012-100760 [pii]
AID - 10.1136/medethics-2012-100760 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Jun;39(6):387-8. doi: 10.1136/medethics-2012-100760. Epub 2012
      Jun 7.


PMID- 22678860
OWN - NLM
STAT- MEDLINE
DCOM- 20121009
LR  - 20120608
IS  - 1931-7581 (Electronic)
IS  - 0027-2507 (Linking)
VI  - 79
IP  - 3
DP  - 2012 May-Jun
TI  - Donation after cardiac death in abdominal organ transplantation.
PG  - 365-75
LID - 10.1002/msj.21309 [doi]
AB  - This article reviews the field of donation after cardiac death, focusing on the
      history, ethicolegal issues, clinical outcomes, best practices, operative
      techniques, and emerging strategies to optimize utilization of this resource.
      Donation after cardiac death is one effective way to decrease the organ shortage 
      and has contributed the largest recent increase in abdominal organ allografts.
      Currently, donation after cardiac death organs confer an increased risk of
      ischemic cholangiopathy after liver transplant and of delayed graft function
      after kidney transplant. As this field matures, risk factors for donation after
      cardiac death organ transplant will be further identified and clinical outcomes
      will improve as a result of protocol standardization and ongoing research.
CI  - (c) 2012 Mount Sinai School of Medicine.
FAU - Reich, David J
AU  - Reich DJ
AD  - Division of Multi Organ Transplantation and Hepatobiliary Surgery Drexel
      University College of Medicine, Philadelphia, PA, USA. david.reich@drexelmed.edu
FAU - Guy, Stephen R
AU  - Guy SR
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Mt Sinai J Med
JT  - The Mount Sinai journal of medicine, New York
JID - 0241032
SB  - IM
MH  - Abdomen/*surgery
MH  - *Death
MH  - Humans
MH  - Kidney Transplantation/*methods
MH  - Liver Transplantation/*methods
MH  - Pancreas Transplantation/*methods
MH  - Prognosis
MH  - Risk Assessment
MH  - Time Factors
MH  - *Tissue Donors
MH  - Treatment Outcome
EDAT- 2012/06/09 06:00
MHDA- 2012/10/10 06:00
CRDT- 2012/06/09 06:00
PHST- 2012/06/09 06:00 [entrez]
PHST- 2012/06/09 06:00 [pubmed]
PHST- 2012/10/10 06:00 [medline]
AID - 10.1002/msj.21309 [doi]
PST - ppublish
SO  - Mt Sinai J Med. 2012 May-Jun;79(3):365-75. doi: 10.1002/msj.21309.


PMID- 22678272
OWN - NLM
STAT- MEDLINE
DCOM- 20120808
LR  - 20211021
IS  - 1476-4687 (Electronic)
IS  - 0028-0836 (Linking)
VI  - 486
IP  - 7401
DP  - 2012 Jun 6
TI  - Ethics: Two faces of marine ecology research.
PG  - 34
LID - 10.1038/486034b [doi]
FAU - Brunnschweiler, Juerg
AU  - Brunnschweiler J
LA  - eng
PT  - Letter
PT  - Comment
DEP - 20120606
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
SB  - IM
CON - Nature. 2012 Apr 26;484(7395):415. PMID: 22538561
CON - Nature. 2012 Apr 26;484(7395):432-4. PMID: 22538582
MH  - *Communication
MH  - *Ethics, Research
MH  - Female
MH  - Humans
MH  - Pregnancy
MH  - *Research
MH  - *Research Personnel
MH  - *Security Measures
EDAT- 2012/06/09 06:00
MHDA- 2012/08/09 06:00
CRDT- 2012/06/09 06:00
PHST- 2012/06/09 06:00 [entrez]
PHST- 2012/06/09 06:00 [pubmed]
PHST- 2012/08/09 06:00 [medline]
AID - 486034b [pii]
AID - 10.1038/486034b [doi]
PST - epublish
SO  - Nature. 2012 Jun 6;486(7401):34. doi: 10.1038/486034b.


PMID- 22678270
OWN - NLM
STAT- MEDLINE
DCOM- 20120808
LR  - 20211021
IS  - 1476-4687 (Electronic)
IS  - 0028-0836 (Linking)
VI  - 486
IP  - 7401
DP  - 2012 Jun 6
TI  - Law: Pitfalls of Romania's ethics council.
PG  - 34
LID - 10.1038/486034d [doi]
FAU - Voiculescu, Octavian
AU  - Voiculescu O
LA  - eng
PT  - Letter
PT  - Comment
DEP - 20120606
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
SB  - IM
CON - Nature. 2012 May 17;485(7398):289. PMID: 22596129
MH  - *Federal Government
MH  - *Plagiarism
MH  - Research Personnel/*ethics
EDAT- 2012/06/09 06:00
MHDA- 2012/08/09 06:00
CRDT- 2012/06/09 06:00
PHST- 2012/06/09 06:00 [entrez]
PHST- 2012/06/09 06:00 [pubmed]
PHST- 2012/08/09 06:00 [medline]
AID - 486034d [pii]
AID - 10.1038/486034d [doi]
PST - epublish
SO  - Nature. 2012 Jun 6;486(7401):34. doi: 10.1038/486034d.


PMID- 22678171
OWN - NLM
STAT- MEDLINE
DCOM- 20130403
LR  - 20211021
IS  - 1432-2218 (Electronic)
IS  - 0930-2794 (Linking)
VI  - 26
IP  - 11
DP  - 2012 Nov
TI  - Efficacy and safety of the novel electrosurgical vessel sealing and cutting
      instrument BiCision(R).
PG  - 3334-43
LID - 10.1007/s00464-012-2337-x [doi]
AB  - BACKGROUND: The use of energy-based tissue-sealing and cutting instruments is
      becoming more and more popular in visceral, urological, and gynecological
      surgery. For their safe and efficacious use in clinical practice, such
      instruments have to reliably seal vessels with a minimal sealing failure rate,
      cause minimal thermal damage to adjacent tissue, and have good cutting qualities.
      METHODS: The efficacy and safety of the novel energy-based instrument for
      dissection, hemostasis and cutting (BiCision((R)), ERBE) was compared to a
      commercially available device (EnSeal((R)), Ethicon Endo-Surgery). We
      investigated vessel-sealing reliability (success rate), sealing quality and
      sealing time, lateral thermal damage cutting quality, tissue sticking to the
      instrument, burst pressure and delayed complications in an acute and chronic pig 
      model after splenectomy, small bowel resection, nephrectomy,
      salpingo-oophorectomy, and sealing of peripheral vessels. RESULTS: For all
      parameters investigated, BiCision((R)) was at least equivalent to EnSeal((R)).
      BiCision((R)) was even superior to EnSeal((R)) with respect to the burst pressure
      in arteries (p = 0.044) and veins (p = 0.023) and the cut quality in all
      locations (arteries, p = 0.0009; veins, p = 0.043). The course of the 7-day
      chronic study was uneventful except for one animal that developed an intestinal
      obstruction. None of the animals showed any signs of postoperative bleeding. On
      second-look laparotomy at day 7, macroscopic inspection of the sealed tissue and 
      vessels did not show any signs of complications or evidence that bleeding had
      occurred. Histologically, the integrity of vessel wall fusion, thermal
      alterations, and inflammatory reactions were comparable, confirming substantial
      equivalence. CONCLUSION: We demonstrated that the efficacy and quality of vessel 
      sealing with BiCision((R)) is at least equivalent to those of EnSeal((R)) for
      vessel diameters up to 7 mm. Since EnSeal((R)) has already been shown to be safe 
      in clinical practice, BiCision((R)) should be as reliable as EnSeal((R)) under
      clinical conditions.
FAU - Rothmund, Ralf
AU  - Rothmund R
AD  - University Hospital for Women, University of Tuebingen, Calwerstr. 7/1, 72076,
      Tuebingen, Germany. Ralf.Rothmund@med.uni-tuebingen.de
FAU - Kraemer, Bernhard
AU  - Kraemer B
FAU - Neis, Felix
AU  - Neis F
FAU - Brucker, Sara
AU  - Brucker S
FAU - Wallwiener, Markus
AU  - Wallwiener M
FAU - Reda, Ali
AU  - Reda A
FAU - Hausch, Andrea
AU  - Hausch A
FAU - Scharpf, Marcus
AU  - Scharpf M
FAU - Szyrach, Mara Natascha
AU  - Szyrach MN
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120608
PL  - Germany
TA  - Surg Endosc
JT  - Surgical endoscopy
JID - 8806653
SB  - IM
MH  - Animals
MH  - Electrosurgery/adverse effects/*instrumentation
MH  - Equipment Design
MH  - Hemostasis, Surgical/adverse effects/*instrumentation
MH  - Swine
EDAT- 2012/06/09 06:00
MHDA- 2013/04/04 06:00
CRDT- 2012/06/09 06:00
PHST- 2011/11/30 00:00 [received]
PHST- 2012/04/16 00:00 [accepted]
PHST- 2012/06/09 06:00 [entrez]
PHST- 2012/06/09 06:00 [pubmed]
PHST- 2013/04/04 06:00 [medline]
AID - 10.1007/s00464-012-2337-x [doi]
PST - ppublish
SO  - Surg Endosc. 2012 Nov;26(11):3334-43. doi: 10.1007/s00464-012-2337-x. Epub 2012
      Jun 8.


PMID- 22677697
OWN - NLM
STAT- MEDLINE
DCOM- 20130517
LR  - 20220408
IS  - 1873-4863 (Electronic)
IS  - 0168-1656 (Linking)
VI  - 162
IP  - 1
DP  - 2012 Nov 30
TI  - Bioengineering of carbon fixation, biofuels, and biochemicals in cyanobacteria
      and plants.
PG  - 134-47
LID - 10.1016/j.jbiotec.2012.05.006 [doi]
LID - S0168-1656(12)00278-7 [pii]
AB  - Development of sustainable energy is a pivotal step towards solutions for today's
      global challenges, including mitigating the progression of climate change and
      reducing dependence on fossil fuels. Biofuels derived from agricultural crops
      have already been commercialized. However the impacts on environmental
      sustainability and food supply have raised ethical questions about the current
      practices. Cyanobacteria have attracted interest as an alternative means for
      sustainable energy productions. Being aquatic photoautotrophs they can be
      cultivated in non-arable lands and do not compete for land for food production.
      Their rich genetic resources offer means to engineer metabolic pathways for
      synthesis of valuable bio-based products. Currently the major obstacle in
      industrial-scale exploitation of cyanobacteria as the economically sustainable
      production hosts is low yields. Much effort has been made to improve the carbon
      fixation and manipulating the carbon allocation in cyanobacteria and their
      evolutionary photosynthetic relatives, algae and plants. This review aims at
      providing an overview of the recent progress in the bioengineering of carbon
      fixation and allocation in cyanobacteria; wherever relevant, the progress made in
      plants and algae is also discussed as an inspiration for future application in
      cyanobacteria.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Rosgaard, Lisa
AU  - Rosgaard L
AD  - Department of Plant Biology and Biotechnology, Faculty of Sciences, University of
      Copenhagen, Thorvaldsensvej 40, Frederiksberg 1871, Denmark.
FAU - de Porcellinis, Alice Jara
AU  - de Porcellinis AJ
FAU - Jacobsen, Jacob H
AU  - Jacobsen JH
FAU - Frigaard, Niels-Ulrik
AU  - Frigaard NU
FAU - Sakuragi, Yumiko
AU  - Sakuragi Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120605
PL  - Netherlands
TA  - J Biotechnol
JT  - Journal of biotechnology
JID - 8411927
RN  - 0 (Biofuels)
SB  - IM
MH  - *Biofuels
MH  - Carbon Cycle
MH  - Cyanobacteria/*chemistry/*metabolism
MH  - Metabolic Engineering
MH  - Metabolic Networks and Pathways
MH  - Plants/*chemistry/*metabolism
EDAT- 2012/06/09 06:00
MHDA- 2013/05/18 06:00
CRDT- 2012/06/09 06:00
PHST- 2012/02/13 00:00 [received]
PHST- 2012/05/15 00:00 [revised]
PHST- 2012/05/21 00:00 [accepted]
PHST- 2012/06/09 06:00 [entrez]
PHST- 2012/06/09 06:00 [pubmed]
PHST- 2013/05/18 06:00 [medline]
AID - S0168-1656(12)00278-7 [pii]
AID - 10.1016/j.jbiotec.2012.05.006 [doi]
PST - ppublish
SO  - J Biotechnol. 2012 Nov 30;162(1):134-47. doi: 10.1016/j.jbiotec.2012.05.006. Epub
      2012 Jun 5.


PMID- 22677531
OWN - NLM
STAT- MEDLINE
DCOM- 20121106
LR  - 20211021
IS  - 0027-5107 (Print)
IS  - 0027-5107 (Linking)
VI  - 751
IP  - 2
DP  - 2012 Oct-Dec
TI  - Ionizing radiation biomarkers for potential use in epidemiological studies.
PG  - 258-286
LID - S1383-5742(12)00042-7 [pii]
LID - 10.1016/j.mrrev.2012.05.003 [doi]
AB  - Ionizing radiation is a known human carcinogen that can induce a variety of
      biological effects depending on the physical nature, duration, doses and
      dose-rates of exposure. However, the magnitude of health risks at low doses and
      dose-rates (below 100mSv and/or 0.1mSvmin(-1)) remains controversial due to a
      lack of direct human evidence. It is anticipated that significant insights will
      emerge from the integration of epidemiological and biological research, made
      possible by molecular epidemiology studies incorporating biomarkers and
      bioassays. A number of these have been used to investigate exposure, effects and 
      susceptibility to ionizing radiation, albeit often at higher doses and dose
      rates, with each reflecting time-limited cellular or physiological alterations.
      This review summarises the multidisciplinary work undertaken in the framework of 
      the European project DoReMi (Low Dose Research towards Multidisciplinary
      Integration) to identify the most appropriate biomarkers for use in population
      studies. In addition to logistical and ethical considerations for conducting
      large-scale epidemiological studies, we discuss the relevance of their use for
      assessing the effects of low dose ionizing radiation exposure at the cellular and
      physiological level. We also propose a temporal classification of biomarkers that
      may be relevant for molecular epidemiology studies which need to take into
      account the time elapsed since exposure. Finally, the integration of biology with
      epidemiology requires careful planning and enhanced discussions between the
      epidemiology, biology and dosimetry communities in order to determine the most
      important questions to be addressed in light of pragmatic considerations
      including the appropriate population to be investigated (occupationally,
      environmentally or medically exposed), and study design. The consideration of the
      logistics of biological sample collection, processing and storing and the choice 
      of biomarker or bioassay, as well as awareness of potential confounding factors, 
      are also essential.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Pernot, Eileen
AU  - Pernot E
AD  - Centre for Research in Environmental Epidemiology (CREAL), Radiation programme,
      IMIM (Hospital del Mar Research Institute) and CIBER Epidemiologia y Salud
      Publica (CIBERESP), Barcelona Biomedical Research Park (PRBB), Doctor Aiguader,
      88, 08003 Barcelona, Spain. Electronic address: epernot@creal.cat.
FAU - Hall, Janet
AU  - Hall J
AD  - Institut Curie, Inserm U612, Centre Universitaire, Bats 110-112, Orsay 91405,
      France.
FAU - Baatout, Sarah
AU  - Baatout S
AD  - Belgian Nuclear Research Center (SCK-CEN), Boeretang 200, BE-2400 Mol, Belgium;
      University of Gent, BE-9000 Gent, Belgium.
FAU - Benotmane, Mohammed Abderrafi
AU  - Benotmane MA
AD  - Belgian Nuclear Research Center (SCK-CEN), Boeretang 200, BE-2400 Mol, Belgium.
FAU - Blanchardon, Eric
AU  - Blanchardon E
AD  - Institut de Radioprotection et de Surete Nucleaire (IRSN), Internal Dosimetry
      Department, 31 avenue de la Division Leclerc, 92260 Fontenay-aux-Roses, France.
FAU - Bouffler, Simon
AU  - Bouffler S
AD  - Health Protection Agency (HPA), Biological Effects Department, Centre for
      Radiation, Chemical and Environmental Hazards, Chilton, Didcot, Oxfordshire OX11 
      0RQ, UK.
FAU - El Saghire, Houssein
AU  - El Saghire H
AD  - Belgian Nuclear Research Center (SCK-CEN), Boeretang 200, BE-2400 Mol, Belgium;
      University of Gent, BE-9000 Gent, Belgium.
FAU - Gomolka, Maria
AU  - Gomolka M
AD  - Federal Office for Radiation Protection, Department Radiation Protection and
      Health, Ingolstadter Landstr. 1, 85764 Neuherberg, Germany.
FAU - Guertler, Anne
AU  - Guertler A
AD  - Federal Office for Radiation Protection, Department Radiation Protection and
      Health, Ingolstadter Landstr. 1, 85764 Neuherberg, Germany.
FAU - Harms-Ringdahl, Mats
AU  - Harms-Ringdahl M
AD  - Centre for Radiation Protection Research (CRPR), Department of Genetics,
      Microbiology and Toxicology, Stockholm University, SE 106 91 Stockholm, Sweden.
FAU - Jeggo, Penny
AU  - Jeggo P
AD  - Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton, BN1
      9QG, UK.
FAU - Kreuzer, Michaela
AU  - Kreuzer M
AD  - Federal Office for Radiation Protection, Department Radiation Protection and
      Health, Ingolstadter Landstr. 1, 85764 Neuherberg, Germany.
FAU - Laurier, Dominique
AU  - Laurier D
AD  - Institut de Radioprotection et de Surete Nucleaire (IRSN), Radiobiology and
      Epidemiology Department, 31avenue de la Division Leclerc, 92260
      Fontenay-aux-Roses, France.
FAU - Lindholm, Carita
AU  - Lindholm C
AD  - Radiation and Nuclear Safety Authority, Laippatie 4, 00880 Helsinki, Finland.
FAU - Mkacher, Radhia
AU  - Mkacher R
AD  - Commissariat a l'Energie Atomique (CEA), Laboratoire de Radiobiologie et
      Oncologie (LRO), 18, Route du Panorama - BP6, 92265 Fontenay-aux-Roses, France.
FAU - Quintens, Roel
AU  - Quintens R
AD  - Belgian Nuclear Research Center (SCK-CEN), Boeretang 200, BE-2400 Mol, Belgium.
FAU - Rothkamm, Kai
AU  - Rothkamm K
AD  - Health Protection Agency (HPA), Biological Effects Department, Centre for
      Radiation, Chemical and Environmental Hazards, Chilton, Didcot, Oxfordshire OX11 
      0RQ, UK.
FAU - Sabatier, Laure
AU  - Sabatier L
AD  - Commissariat a l'Energie Atomique (CEA), Laboratoire de Radiobiologie et
      Oncologie (LRO), 18, Route du Panorama - BP6, 92265 Fontenay-aux-Roses, France.
FAU - Tapio, Soile
AU  - Tapio S
AD  - Helmholtz Zentrum Munchen (HGMU), German Research Center for Environmental
      Health, Ingolstaedter Landstrasse 1, D-85764 Neuherberg, Germany.
FAU - de Vathaire, Florent
AU  - de Vathaire F
AD  - Institut National de la Sante et de la Recherche Medicale (INSERM), U1018,
      Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif cedex,
      France.
FAU - Cardis, Elisabeth
AU  - Cardis E
AD  - Centre for Research in Environmental Epidemiology (CREAL), Radiation programme,
      IMIM (Hospital del Mar Research Institute) and CIBER Epidemiologia y Salud
      Publica (CIBERESP), Barcelona Biomedical Research Park (PRBB), Doctor Aiguader,
      88, 08003 Barcelona, Spain. Electronic address: ecardis@creal.cat.
LA  - eng
GR  - G1000050/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120604
PL  - Netherlands
TA  - Mutat Res
JT  - Mutation research
JID - 0400763
RN  - 0 (Biomarkers)
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - *Biomarkers
MH  - Cells, Cultured
MH  - Chromosome Aberrations
MH  - DNA Damage
MH  - *Epidemiologic Studies
MH  - Epigenesis, Genetic
MH  - Humans
MH  - Metabolomics
MH  - Molecular Epidemiology
MH  - *Radiation, Ionizing
MH  - Reactive Oxygen Species
EDAT- 2012/06/09 06:00
MHDA- 2012/11/07 06:00
CRDT- 2012/06/09 06:00
PHST- 2012/02/16 00:00 [received]
PHST- 2012/05/04 00:00 [revised]
PHST- 2012/05/28 00:00 [accepted]
PHST- 2012/06/09 06:00 [entrez]
PHST- 2012/06/09 06:00 [pubmed]
PHST- 2012/11/07 06:00 [medline]
AID - S1383-5742(12)00042-7 [pii]
AID - 10.1016/j.mrrev.2012.05.003 [doi]
PST - ppublish
SO  - Mutat Res. 2012 Oct-Dec;751(2):258-286. doi: 10.1016/j.mrrev.2012.05.003. Epub
      2012 Jun 4.


PMID- 22677466
OWN - NLM
STAT- MEDLINE
DCOM- 20130610
LR  - 20121009
IS  - 2173-9188 (Electronic)
IS  - 1130-1406 (Linking)
VI  - 29
IP  - 4
DP  - 2012 Oct-Dec
TI  - [Fungus patents: from Pasteur to the present day].
PG  - 200-4
LID - 10.1016/j.riam.2012.05.004 [doi]
LID - S1130-1406(12)00061-7 [pii]
AB  - At the end of the 19(th) century, the American Patent Office granted the patent
      known as "Pasteur's application", claiming the protection of a yeast strain.
      Since that date, the debate around biotechnology patents, especially for those
      that affect living organisms or part of them, has grown exponentially. In the
      present article, the Patent Law is reviewed, pointing out the particular problems
      about fungi or parts of them. Also, some of the fungus patents are discussed from
      the perspective of the ethical, economical, social and environmental aspects of
      these kind of patents.
CI  - Copyright (c) 2012 Revista Iberoamericana de Micologia. Published by Elsevier
      Espana. All rights reserved.
FAU - Bernardo-Alvarez, Maria Angela
AU  - Bernardo-Alvarez MA
AD  - Departamento de Derecho Publico, Facultad de Derecho, Universidad de Leon, Leon, 
      Espana. maberalv@gmail.com
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Patentes fungicas: de Pasteur a nuestros dias.
DEP - 20120605
PL  - Spain
TA  - Rev Iberoam Micol
JT  - Revista iberoamericana de micologia
JID - 9425531
SB  - IM
MH  - Biotechnology
MH  - *Fungi
MH  - *Patents as Topic
EDAT- 2012/06/09 06:00
MHDA- 2013/06/12 06:00
CRDT- 2012/06/09 06:00
PHST- 2012/02/01 00:00 [received]
PHST- 2012/05/07 00:00 [revised]
PHST- 2012/05/08 00:00 [accepted]
PHST- 2012/06/09 06:00 [entrez]
PHST- 2012/06/09 06:00 [pubmed]
PHST- 2013/06/12 06:00 [medline]
AID - S1130-1406(12)00061-7 [pii]
AID - 10.1016/j.riam.2012.05.004 [doi]
PST - ppublish
SO  - Rev Iberoam Micol. 2012 Oct-Dec;29(4):200-4. doi: 10.1016/j.riam.2012.05.004.
      Epub 2012 Jun 5.


PMID- 22676321
OWN - NLM
STAT- MEDLINE
DCOM- 20121213
LR  - 20220317
IS  - 1471-2474 (Electronic)
IS  - 1471-2474 (Linking)
VI  - 13
DP  - 2012 Jun 7
TI  - Prophylactic antibiotic regimens in tumor surgery (PARITY) survey.
PG  - 91
LID - 10.1186/1471-2474-13-91 [doi]
AB  - BACKGROUND: Deep infection following endoprosthetic limb reconstruction for
      sarcoma of the long bones is a devastating complication occurring in 15% of
      sarcoma patients. Optimizing infection protocols and conducting definitive
      surgical trials are critical to improving outcomes. In this study, the PARITY
      (Prophylactic Antibiotic Regimens in Tumor Surgery) investigators aimed to
      examine surgeon preferences in antibiotic prophylaxis and perceptions about
      current evidence, as well as to ascertain interest in resolving uncertainty in
      the evidence with clinical trials. METHODS: We used a cross-sectional survey to
      examine current practice in the prescription of prophylactic antibiotics in
      Musculoskeletal Tumor Surgery. The survey was approved by our institution's
      Ethics Board and emailed to all Active Members of the Musculoskeletal Tumor
      Society (MSTS) and Canadian Orthopaedic Oncology Society (CANOOS). Survey answers
      were collected using an anonymous online survey tool. RESULTS: Of the 96 surgeons
      who received the questionnaire, 72 responded (75% response rate (% CI: 65.5,
      82.5%)). While almost all respondents agreed antibiotic regimens were important
      in reducing the risk of infection, respondents varied considerably in their
      choices of antibiotic regimens and dosages. Although 73% (95% CI: 61, 82%) of
      respondents prescribe a first generation cephalosporin, 25% favor additional
      coverage with an aminoglycoside and/or Vancomycin. Of those who prescribe a
      cephalosporin, 33% prescribe a dosage of one gram for all patients and the
      reminder prescribe up to 2 grams based on body weight. One in three surgeons (95%
      CI: 25, 48%) believes antibiotics could be discontinued after 24 hours but 40%
      (95% CI: 30, 53%) continue antibiotics until the suction drain is removed. Given 
      the ongoing uncertainty in evidence to guide best practices, 90% (95% CI: 81,
      95%) of respondents agreed that they would change their practice if a large
      randomized controlled trial showed clear benefit of an antibiotic drug regimen
      different from what they are currently using. Further support for a clinical
      trial was observed by an overwhelming surgeon interest (87%; 95% CI: 77, 93%) in 
      participating in a multi-center randomized controlled study. CONCLUSION: The
      current lack of guidelines for the prescription of prophylactic antibiotics in
      Musculoskeletal Tumor Surgery has left Orthopaedic Oncologists with varying
      opinions and practices. The lack of current evidence and strong surgeon support
      for participating in a definitive study provides strong rationale for clinical
      trials.
FAU - Hasan, Khaled
AU  - Hasan K
AD  - Department of Surgery, McMaster University, Hamilton, ON, Canada.
      khaled.hasan@medportal.ca
FAU - Racano, Antonella
AU  - Racano A
FAU - Deheshi, Benjamin
AU  - Deheshi B
FAU - Farrokhyar, Forough
AU  - Farrokhyar F
FAU - Wunder, Jay
AU  - Wunder J
FAU - Ferguson, Peter
AU  - Ferguson P
FAU - Holt, Ginger
AU  - Holt G
FAU - Schwartz, Herbert
AU  - Schwartz H
FAU - Petrisor, Brad
AU  - Petrisor B
FAU - Bhandari, Mohit
AU  - Bhandari M
FAU - Ghert, Michelle
AU  - Ghert M
LA  - eng
PT  - Journal Article
DEP - 20120607
PL  - England
TA  - BMC Musculoskelet Disord
JT  - BMC musculoskeletal disorders
JID - 100968565
SB  - IM
MH  - Adult
MH  - Antibiotic Prophylaxis/methods/*statistics & numerical data
MH  - Bone Neoplasms/*surgery
MH  - Cross-Sectional Studies
MH  - Humans
MH  - Middle Aged
MH  - Muscle Neoplasms/*surgery
MH  - Orthopedic Procedures/*methods
MH  - Professional Practice
MH  - Prosthesis-Related Infections/prevention & control
MH  - Societies, Medical
MH  - Surveys and Questionnaires
PMC - PMC3461415
EDAT- 2012/06/09 06:00
MHDA- 2012/12/14 06:00
CRDT- 2012/06/09 06:00
PHST- 2011/07/15 00:00 [received]
PHST- 2012/06/07 00:00 [accepted]
PHST- 2012/06/09 06:00 [entrez]
PHST- 2012/06/09 06:00 [pubmed]
PHST- 2012/12/14 06:00 [medline]
AID - 1471-2474-13-91 [pii]
AID - 10.1186/1471-2474-13-91 [doi]
PST - epublish
SO  - BMC Musculoskelet Disord. 2012 Jun 7;13:91. doi: 10.1186/1471-2474-13-91.


PMID- 22676197
OWN - NLM
STAT- MEDLINE
DCOM- 20121231
LR  - 20211021
IS  - 1744-8042 (Electronic)
IS  - 1462-2416 (Linking)
VI  - 13
IP  - 8
DP  - 2012 Jun
TI  - Return of research results from pharmacogenomic versus disease susceptibility
      studies: what's drugs got to do with it?
PG  - 935-49
LID - 10.2217/pgs.12.59 [doi]
AB  - One of the most controversial ethical issues in genomics research is the return
      of individual research results to research subjects. As new technologies,
      including whole-genome sequencing, provide an increased opportunity for
      researchers to find clinically relevant research results, the questions related
      to if, when and how individual research results should be returned become more
      central to the ethical conduct of genomic research. In the absence of federal
      guidance on this issue, many groups and individuals have developed
      recommendations and suggestions to address these questions. Most of these
      recommendations have focused on the return of individual results from disease
      susceptibility studies. However, in addition to predicting the development of
      disease, genomic research also includes predicting an individual's response to
      drugs, especially the risk of developing adverse events. This article evaluates
      and compares the return of individual research results from disease
      susceptibility studies versus pharmacogenomic studies.
FAU - Dressler, Lynn G
AU  - Dressler LG
AD  - University of North Carolina, Eshelman School of Pharmacy, Division of
      Pharmaceutical Outcomes & Policy, Institute of Pharmacogenomics & Individualized 
      Therapy, 120 Mason Farm Rd, Genetic Medicine Building, Rm 1091, CB7361, Chapel
      Hill, NC 27599-7361, USA. lynn_dressler@unc.edu
LA  - eng
GR  - P50 HG004488/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PL  - England
TA  - Pharmacogenomics
JT  - Pharmacogenomics
JID - 100897350
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Disease Susceptibility
MH  - *Genome, Human
MH  - Genomics/*ethics
MH  - Humans
MH  - *Pharmacogenetics/ethics/methods
MH  - Research Subjects
MH  - Risk Assessment
PMC - PMC4539533
MID - NIHMS405023
EDAT- 2012/06/09 06:00
MHDA- 2013/01/01 06:00
CRDT- 2012/06/09 06:00
PHST- 2012/06/09 06:00 [entrez]
PHST- 2012/06/09 06:00 [pubmed]
PHST- 2013/01/01 06:00 [medline]
AID - 10.2217/pgs.12.59 [doi]
PST - ppublish
SO  - Pharmacogenomics. 2012 Jun;13(8):935-49. doi: 10.2217/pgs.12.59.


PMID- 22675697
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20220311
IS  - 1172-6156 (Electronic)
IS  - 1172-6156 (Linking)
VI  - 4
IP  - 2
DP  - 2012 Jun 1
TI  - New Zealand pharmacists' experiences, practices and views regarding antibiotic
      use without prescription.
PG  - 131-40
AB  - INTRODUCTION: Very few studies have investigated pharmacists' views, experiences 
      and practices regarding the use of antibiotics without prescription. This study
      aimed to explore through self-report and hypothetical scenarios what factors
      determine New Zealand pharmacists' behaviour and attitudes towards
      non-prescription use of antibiotics. METHODS: A purposeful sample of 35
      registered community pharmacists of differing ethnic backgrounds was selected
      from a mixture of pharmacies that predominantly either serve New Zealand European
      customers or customers of other ethnicities. Semi-structured interviews including
      general background questions and six hypothetical scenarios were used for the
      investigation. Pharmacists' ethnicity, education, years of experience, and
      customers' ethnicity may influence their views, experiences and practices
      regarding the use of antibiotics without prescription. Customer demand or
      expectation, business orientation and competitiveness within community
      pharmacies, standards and practice of fellow pharmacists, ethics and
      professionalism, legislation, enforcement of the legislation, and apprehension of
      the consequences of such practice were hypothesised to have an effect on
      antibiotic use or supply without prescription by pharmacists. FINDINGS: The
      supply of antibiotics without prescription is not common practice in New Zealand.
      However, personal use of antibiotics without prescription by pharmacists may have
      been underestimated. Pharmacists were aware of legalities surrounding selling and
      using antibiotics and practised accordingly, yet many used antibiotics without
      prescription to treat themselves and/or spouses or partners. Many pharmacists
      also reported that under certain legislative, and regulatory and situational
      conditions they would sell antibiotics without a prescription. CONCLUSION: Views 
      and practices regarding antibiotic use without prescription by community
      pharmacists require further exploration.
FAU - Dameh, Majd
AU  - Dameh M
AD  - School of Pharmacy, University of Otago, Dunedin, New Zealand.
      drmajddameh@gmail.com
FAU - Norris, Pauline
AU  - Norris P
FAU - Green, James
AU  - Green J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120601
PL  - Australia
TA  - J Prim Health Care
JT  - Journal of primary health care
JID - 101524060
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Nonprescription Drugs)
SB  - IM
MH  - Adult
MH  - Anti-Bacterial Agents/*therapeutic use
MH  - *Attitude of Health Personnel
MH  - Female
MH  - Humans
MH  - Male
MH  - New Zealand
MH  - Nonprescription Drugs/*therapeutic use
MH  - Pharmacists/*psychology
MH  - Practice Patterns, Physicians'/*statistics & numerical data
MH  - Qualitative Research
EDAT- 2012/06/08 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/06/08 06:00
PHST- 2012/06/08 06:00 [entrez]
PHST- 2012/06/08 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
PST - epublish
SO  - J Prim Health Care. 2012 Jun 1;4(2):131-40.


PMID- 22675620
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 2090-1313 (Electronic)
IS  - 2090-1305 (Linking)
VI  - 2012
DP  - 2012
TI  - Commonly used severity scores are not good predictors of mortality in sepsis from
      severe leptospirosis: a series of ten patients.
PG  - 532376
LID - 10.1155/2012/532376 [doi]
AB  - Introduction. Severe leptospirosis, also known as Weil's disease, can cause
      multiorgan failure with high mortality. Scoring systems for disease severity have
      not been validated for leptospirosis, and there is no documented method to
      predict mortality. Methods. This is a case series on 10 patients admitted to ICU 
      for multiorgan failure from severe leptospirosis. Data were collected
      retrospectively, with approval from the Institution Ethics Committee. Results.
      Ten patients with severe leptospirosis were admitted in the Patras University
      Hospital ICU in a four-year period. Although, based on SOFA scores, predicted
      mortality was over 80%, seven of 10 patients survived and were discharged from
      the hospital in good condition. There was no association between SAPS II or SOFA 
      scores and mortality, but survivors had significantly lower APACHE II scores
      compared to nonsurvivors. Conclusion. Commonly used severity scores do not seem
      to be useful in predicting mortality in severe leptospirosis. Early ICU admission
      and resuscitation based on a goal-directed therapy protocol are recommended and
      may reduce mortality. However, this study is limited by retrospective data
      collection and small sample size. Data from large prospective studies are needed 
      to validate our findings.
FAU - Velissaris, Dimitrios
AU  - Velissaris D
AD  - Department of Anesthesiology and Critical Care Medicine, Patras University
      Hospital, 26500 Rion, Greece.
FAU - Karanikolas, Menelaos
AU  - Karanikolas M
FAU - Flaris, Nikolaos
AU  - Flaris N
FAU - Fligou, Fotini
AU  - Fligou F
FAU - Marangos, Markos
AU  - Marangos M
FAU - Filos, Kriton S
AU  - Filos KS
LA  - eng
PT  - Journal Article
DEP - 20120521
PL  - Egypt
TA  - Crit Care Res Pract
JT  - Critical care research and practice
JID - 101539357
PMC - PMC3363413
EDAT- 2012/06/08 06:00
MHDA- 2012/06/08 06:01
CRDT- 2012/06/08 06:00
PHST- 2011/10/01 00:00 [received]
PHST- 2012/03/01 00:00 [revised]
PHST- 2012/03/22 00:00 [accepted]
PHST- 2012/06/08 06:00 [entrez]
PHST- 2012/06/08 06:00 [pubmed]
PHST- 2012/06/08 06:01 [medline]
AID - 10.1155/2012/532376 [doi]
PST - ppublish
SO  - Crit Care Res Pract. 2012;2012:532376. doi: 10.1155/2012/532376. Epub 2012 May
      21.


PMID- 22675219
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1715-6181 (Electronic)
IS  - 0008-3194 (Linking)
VI  - 56
IP  - 2
DP  - 2012 Jun
TI  - Developing a model curriculum for ethical practice building at Chiropractic
      Colleges: Part 1: qualitative analysis of opinions from an International
      Workshop.
PG  - 87-91
FAU - Gleberzon, Brian J
AU  - Gleberzon BJ
AD  - Professor & Chair, Department of Chiropractic Therapeutics, CMCC 6100 Leslie St, 
      Toronto, Ontario. M2H 3J1.
FAU - Perle, Stephen M
AU  - Perle SM
FAU - Lamarche, Gilles A
AU  - Lamarche GA
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - J Can Chiropr Assoc
JT  - The Journal of the Canadian Chiropractic Association
JID - 7507184
PMC - PMC3364055
EDAT- 2012/06/08 06:00
MHDA- 2012/06/08 06:01
CRDT- 2012/06/08 06:00
PHST- 2012/06/08 06:00 [entrez]
PHST- 2012/06/08 06:00 [pubmed]
PHST- 2012/06/08 06:01 [medline]
PST - ppublish
SO  - J Can Chiropr Assoc. 2012 Jun;56(2):87-91.


PMID- 22674963
OWN - NLM
STAT- MEDLINE
DCOM- 20130111
LR  - 20120730
IS  - 1552-5732 (Electronic)
IS  - 0890-3344 (Linking)
VI  - 28
IP  - 3
DP  - 2012 Aug
TI  - Milk and social media: online communities and the International Code of Marketing
      of Breast-milk Substitutes.
PG  - 400-6
LID - 10.1177/0890334412447080 [doi]
AB  - BACKGROUND: The advent of social networking sites and other online communities
      presents new opportunities and challenges for the promotion, protection, and
      support of breastfeeding. This study examines the presence of infant formula
      marketing on popular US social media sites, using the World Health Organization
      International Code of Marketing of Breast-milk Substitutes (the Code) as a
      framework. METHODS: We examined to what extent each of 11 infant formula brands
      that are widely available in the US had established a social media presence in
      popular social media venues likely to be visited by expectant parents and
      families with young children. We then examined current marketing practices, using
      the Code as a basis for ethical marketing. RESULTS: Infant formula manufacturers 
      have established a social media presence primarily through Facebook pages,
      interactive features on their own Web sites, mobile apps for new and expecting
      parents, YouTube videos, sponsored reviews on parenting blogs, and other
      financial relationships with parenting blogs. Violations of the Code as well as
      promotional practices unforeseen by the Code were identified. These practices
      included enabling user-generated content that promotes the use of infant formula,
      financial relationships between manufacturers and bloggers, and creation of
      mobile apps for use by parents. An additional concern identified for Code
      enforcement is lack of transparency in social media-based marketing. CONCLUSION: 
      The use of social media for formula marketing may demand new strategies for
      monitoring and enforcing the Code in light of emerging challenges, including
      suggested content for upcoming consideration for World Health Assembly
      resolutions.
FAU - Abrahams, Sheryl W
AU  - Abrahams SW
AD  - Carolina Global Breastfeeding Institute, Department of Maternal and Child Health,
      Gillings School of Global Public Health, The University of North Carolina at
      Chapel Hill, Rosenau Hall, CB# 7445, Chapel Hill, NC 27599-7445, USA.
      swa@email.unc.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120606
PL  - United States
TA  - J Hum Lact
JT  - Journal of human lactation : official journal of International Lactation
      Consultant Association
JID - 8709498
MH  - *Breast Feeding
MH  - *Food Industry/economics/ethics
MH  - Health Policy
MH  - Humans
MH  - Infant
MH  - *Infant Formula/economics/ethics
MH  - Infant, Newborn
MH  - International Cooperation
MH  - Marketing/ethics/*methods
MH  - *Social Media
MH  - Social Networking
MH  - United States
MH  - World Health Organization
EDAT- 2012/06/08 06:00
MHDA- 2013/01/12 06:00
CRDT- 2012/06/08 06:00
PHST- 2012/06/08 06:00 [entrez]
PHST- 2012/06/08 06:00 [pubmed]
PHST- 2013/01/12 06:00 [medline]
AID - 0890334412447080 [pii]
AID - 10.1177/0890334412447080 [doi]
PST - ppublish
SO  - J Hum Lact. 2012 Aug;28(3):400-6. doi: 10.1177/0890334412447080. Epub 2012 Jun 6.


PMID- 22673884
OWN - NLM
STAT- MEDLINE
DCOM- 20130205
LR  - 20121108
IS  - 1523-1755 (Electronic)
IS  - 0085-2538 (Linking)
VI  - 82
IP  - 6
DP  - 2012 Sep
TI  - The Iranian model of living renal transplantation.
PG  - 627-34
LID - 10.1038/ki.2012.219 [doi]
AB  - Organ shortage for transplantation remains a worldwide serious problem for kidney
      patients with end-stage renal failure, and several countries have tried different
      models to address this issue. Iran has 20 years of experience with one such model
      that involves the active role of the government and charity foundations. Patients
      with a desperate demand for a kidney have given rise to a black market of brokers
      and other forms of organ commercialism only accessible to those with sufficient
      financial resources. The current Iranian model has enabled most of the Iranian
      kidney transplant candidates, irrespective of socioeconomic class, to have access
      to kidney transplantation. The Iranian government has committed a large budget
      through funding hospital and staff at the Ministry of Health and Medical
      Education by supporting the brain death donation (BDD) program or redirecting
      part of the budget of living unrelated renal donation (LURD) to the BDD program. 
      It has been shown that it did not prevent the development and progression of a
      BDD program. However, the LURD program is characterized by several controversial 
      procedures (e.g., confrontation of donor and recipient at the end of the
      evaluation procedure along with some financial interactions) that should be
      ethically reviewed. Operational weaknesses such as the lack of a registration
      system and long-term follow-up of the donors are identified as the 'Achilles heel
      of the model'.
FAU - Mahdavi-Mazdeh, Mitra
AU  - Mahdavi-Mazdeh M
AD  - Iranian Tissue Bank Research & Preparation Center, Tehran University of Medical
      Sciences, Tehran, Iran. mmahdavi@sina.tums.ac.ir
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Review
DEP - 20120606
PL  - United States
TA  - Kidney Int
JT  - Kidney international
JID - 0323470
RN  - 0 (Immunosuppressive Agents)
SB  - IM
CIN - Kidney Int. 2012 Sep;82(6):625-6. PMID: 22935881
MH  - Financing, Government
MH  - Government Regulation
MH  - Health Policy
MH  - Health Services Accessibility/economics/ethics/history/legislation &
      jurisprudence/*organization & administration
MH  - Healthcare Disparities/ethics/history/legislation & jurisprudence/*organization &
      administration
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Immunosuppressive Agents/therapeutic use
MH  - Insurance Coverage/organization & administration
MH  - Insurance, Health/organization & administration
MH  - Iran
MH  - Kidney Failure, Chronic/history/*surgery
MH  - *Kidney Transplantation/economics/history/legislation & jurisprudence
MH  - Living Donors/history/legislation & jurisprudence/*supply & distribution
MH  - *Models, Organizational
MH  - Program Development
MH  - Program Evaluation
MH  - Socioeconomic Factors
MH  - Tissue and Organ Procurement/economics/history/legislation &
      jurisprudence/*organization & administration
EDAT- 2012/06/08 06:00
MHDA- 2013/02/06 06:00
CRDT- 2012/06/08 06:00
PHST- 2012/06/08 06:00 [entrez]
PHST- 2012/06/08 06:00 [pubmed]
PHST- 2013/02/06 06:00 [medline]
AID - S0085-2538(15)55619-6 [pii]
AID - 10.1038/ki.2012.219 [doi]
PST - ppublish
SO  - Kidney Int. 2012 Sep;82(6):627-34. doi: 10.1038/ki.2012.219. Epub 2012 Jun 6.


PMID- 22673560
OWN - NLM
STAT- MEDLINE
DCOM- 20131021
LR  - 20151119
IS  - 1878-1799 (Electronic)
IS  - 1871-5192 (Linking)
VI  - 26
IP  - 2
DP  - 2013 Jun
TI  - The dwelling space of postnatal care.
PG  - 110-3
LID - 10.1016/j.wombi.2012.05.001 [doi]
LID - S1871-5192(12)00034-0 [pii]
AB  - BACKGROUND: This paper considers the dwelling space of postnatal care, how
      being-there feels for the woman going through the experience of matrescence. The 
      research takes a hermeneutic approach and draws on philosophical notions from
      Heidegger. QUESTION: 'What is the nature of the dwelling space of valued
      postnatal care?'. METHODS: Appropriate ethics approval was gained. Participants
      were midwives, nurses, women, and other relevant stakeholders. There were 4 focus
      groups involving 11 participants and 19 individual interviews. Data collection
      was conducted over a one week period by a team of three researchers. An interview
      schedule had been organised by the administrator at the Centre. Participants
      chose whether to come to the centre to be interviewed, or be interviewed in their
      own homes. Most interviews were an hour. All interviews were tape recorded and
      transcribed, with the participant's permission. Data was analysed through a
      hermeneutic process set in the context of related literature. FINDINGS: When
      women are invited into a dwelling space that strengthens them they feel
      'mothered': being listened to, have their needs anticipated, and are cared for in
      a loving manner. In such a way they grow confidence. A child health nurse
      reported the difference such care made to on-going mothering at home.
      IMPLICATIONS FOR PRACTICE: All women deserve a dwelling space in their early days
      of matrescence. Small birthing centres perhaps achieve such care and ambience
      more easily than large institutional units. Nevertheless, wherever the place,
      practices need to be enabled that foster the spirit of dwelling.
CI  - Copyright (c) 2012 Australian College of Midwives. Published by Elsevier Ltd. All
      rights reserved.
FAU - Smythe, Elizabeth A
AU  - Smythe EA
AD  - Centre for Midwifery and Women's Health, School of Health Care Practice, Auckland
      University of Technology, P.O. Box 92 006, Auckland 1142, New Zealand.
      Liz.smythe@aut.ac.nz
FAU - Payne, Deborah
AU  - Payne D
FAU - Wilson, Sally
AU  - Wilson S
FAU - Wynyard, Sue
AU  - Wynyard S
LA  - eng
PT  - Journal Article
DEP - 20120604
PL  - Netherlands
TA  - Women Birth
JT  - Women and birth : journal of the Australian College of Midwives
JID - 101266131
MH  - Female
MH  - Focus Groups
MH  - Humans
MH  - Infant Care/*methods
MH  - Infant, Newborn
MH  - Interviews as Topic
MH  - Mothers/*psychology
MH  - Nurse-Patient Relations
MH  - Postnatal Care/*methods
MH  - Pregnancy
MH  - Qualitative Research
MH  - Rural Population
MH  - *Social Support
MH  - Surveys and Questionnaires
EDAT- 2012/06/08 06:00
MHDA- 2013/10/22 06:00
CRDT- 2012/06/08 06:00
PHST- 2011/11/03 00:00 [received]
PHST- 2012/05/04 00:00 [revised]
PHST- 2012/05/09 00:00 [accepted]
PHST- 2012/06/08 06:00 [entrez]
PHST- 2012/06/08 06:00 [pubmed]
PHST- 2013/10/22 06:00 [medline]
AID - S1871-5192(12)00034-0 [pii]
AID - 10.1016/j.wombi.2012.05.001 [doi]
PST - ppublish
SO  - Women Birth. 2013 Jun;26(2):110-3. doi: 10.1016/j.wombi.2012.05.001. Epub 2012
      Jun 4.


PMID- 22673244
OWN - NLM
STAT- MEDLINE
DCOM- 20120821
LR  - 20220321
IS  - 2163-0763 (Electronic)
IS  - 2163-0755 (Linking)
VI  - 72
IP  - 5
DP  - 2012 May
TI  - Withdrawal of care: a 10-year perspective at a Level I trauma center.
PG  - 1186-93
LID - 10.1097/TA.0b013e31824d0e57 [doi]
AB  - BACKGROUND: Withdrawal or limitation of care (WLC) in trauma patients has not
      been well studied. We reviewed 10 years of deaths at our adult Level I trauma
      center to identify the patients undergoing WLC and to describe the process of
      trauma surgeon-managed WLC. METHODS: This is a retrospective review of WLC. Each 
      patient was assigned to one of three modes of WLC: care withdrawn, limited or no 
      resuscitation, or organ harvest. Frequency, timing, and circumstances of WLC,
      including family involvement, ethics committee consultation, palliative care, and
      hospice, were reviewed. RESULTS: From 2000 through 2009, 375 patients died with
      WLC (54% of all deaths; 93% at >/= 24 hours). For age >/= 65 years, 80% were WLC.
      Overall, 15% had advance directive documents. Traumatic brain or high cervical
      spine injury was the cause of death in 63%. Factors associated with WLC included 
      age, comorbidities, injury mechanism and severity, and nontrauma activation
      status. At time of death, 316 (84%) WLC were under trauma surgeon management. In 
      this group, mode of WLC was care withdrawn in 74%, organ harvest in 20%, and
      limited or no resuscitation in 6%. Rationale for WLC in non-organ harvest
      patients was poor neurologic prognosis in 86% and futility in 76%. When family
      was identified, end-of-life discussions with physicians occurred in 100%.
      Conflicts over WLC occurred in 6.6% and were not associated with any demographic 
      group. Ethics committee was involved in 2.8%. For care-withdrawn patients, median
      time to death from first WLC order was 6.6 hours. Palliative care and hospice
      consults (6% and 9%) increased yearly. CONCLUSIONS: WLC occurred in over 50% of
      all trauma deaths and exceeded 90% at >/= 24 hours. Hospice and palliative care
      were increasingly important adjuncts to WLC. Guidelines for WLC should be
      developed to ensure quality end-of-life care for trauma patients in whom further 
      care is futile. LEVEL OF EVIDENCE: III, therapeutic study.
FAU - Sise, Michael J
AU  - Sise MJ
AD  - Trauma Service, Scripps Mercy Hospital, San Diego, California 92103, USA.
      sise.mike@scrippshealth.org
FAU - Sise, C Beth
AU  - Sise CB
FAU - Thorndike, Jonathan F
AU  - Thorndike JF
FAU - Kahl, Jessica E
AU  - Kahl JE
FAU - Calvo, Richard Y
AU  - Calvo RY
FAU - Shackford, Steven R
AU  - Shackford SR
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Trauma Acute Care Surg
JT  - The journal of trauma and acute care surgery
JID - 101570622
SB  - IM
MH  - Adult
MH  - California/epidemiology
MH  - *Ethics, Medical
MH  - Female
MH  - Humans
MH  - Male
MH  - Medical Futility/*ethics
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Survival Rate/trends
MH  - Time Factors
MH  - Trauma Centers/*statistics & numerical data
MH  - Withholding Treatment/*statistics & numerical data
MH  - Wounds and Injuries/mortality/*therapy
EDAT- 2012/06/08 06:00
MHDA- 2012/08/22 06:00
CRDT- 2012/06/08 06:00
PHST- 2012/06/08 06:00 [entrez]
PHST- 2012/06/08 06:00 [pubmed]
PHST- 2012/08/22 06:00 [medline]
AID - 10.1097/TA.0b013e31824d0e57 [doi]
AID - 01586154-201205000-00009 [pii]
PST - ppublish
SO  - J Trauma Acute Care Surg. 2012 May;72(5):1186-93. doi:
      10.1097/TA.0b013e31824d0e57.


PMID- 22673121
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20220330
IS  - 1865-1380 (Electronic)
IS  - 1865-1372 (Linking)
VI  - 5
IP  - 1
DP  - 2012 Jun 6
TI  - Diagnostic values of ultrasound and the Modified Alvarado Scoring System in acute
      appendicitis.
PG  - 26
LID - 10.1186/1865-1380-5-26 [doi]
AB  - BACKGROUND: Making the diagnosis of acute appendicitis is difficult, and is
      important for preventing perforation of the appendix and negative appendectomy
      results. Ultrasound and clinical scoring systems are very helpful in making the
      diagnosis. Ultrasound is non-invasive, available and cost-effective, and can
      accomplish more than CT scans. However, there is no certainty about its effect on
      the clinical outcomes of patients, and it is operator dependent. Counting the
      neutrophils as a parameter of the Alvarado Scale is not routine in many
      laboratories, so we decided to evaluate the diagnostic value of the Modified
      Alvarado Scaling System (MASS) by omitting the neutrophil count and
      ultrasonography. METHODS: After ethical approval of methodology in Tehran
      University of Medical Sciences ethical committee, we collected the data. During 9
      months, 75 patients with right lower quadrant pain were enrolled in the study,
      and underwent abdominal ultrasonography and appendectomy, with pathological
      evaluation of the appendix. The MASS score was calculated for these patients and 
      compared with pathology results. RESULTS: Fifty-five male and 20 female patients 
      were assessed. Of these patients 89.3% had acute appendicitis. The sensitivity,
      specificity, PPV, NPV and accuracy rate of ultrasonography was 71.2%, 83.3%,
      97.4%, 25% and 72.4%, respectively. By taking a cutoff point of 7 for the MASS
      score, a sensitivity of 65.7%, specificity of 37.5%, PPV of 89.8%, NPV of 11.5%
      and accuracy of 62.7% were calculated. Using the cutoff point of 6, a sensitivity
      of 85.1%, specificity of 25%, PPV of 90.5%, NPV of 16.7% and accuracy of 78.7%
      were obtained. CONCLUSION: Ultrasound provides reliable findings for helping to
      diagnose acute appendicitis in our hospital. A cutoff point of 6 for the MASS
      score will yield more sensitivity and a better diagnosis of appendicitis, though 
      with an increase in negative appendectomy.
FAU - Nasiri, Shirzad
AU  - Nasiri S
AD  - Tehran University of Medical Sciences, Shariati Hospital, North Karegar Avenue,
      Tehran, Iran. nasiri@razi.tums.ac.ir.
FAU - Mohebbi, Fatemeh
AU  - Mohebbi F
FAU - Sodagari, Nassim
AU  - Sodagari N
FAU - Hedayat, Anushiravan
AU  - Hedayat A
LA  - eng
PT  - Journal Article
DEP - 20120606
PL  - England
TA  - Int J Emerg Med
JT  - International journal of emergency medicine
JID - 101469435
PMC - PMC3410771
EDAT- 2012/06/08 06:00
MHDA- 2012/06/08 06:01
CRDT- 2012/06/08 06:00
PHST- 2012/02/03 00:00 [received]
PHST- 2012/06/06 00:00 [accepted]
PHST- 2012/06/08 06:00 [entrez]
PHST- 2012/06/08 06:00 [pubmed]
PHST- 2012/06/08 06:01 [medline]
AID - 1865-1380-5-26 [pii]
AID - 10.1186/1865-1380-5-26 [doi]
PST - epublish
SO  - Int J Emerg Med. 2012 Jun 6;5(1):26. doi: 10.1186/1865-1380-5-26.


PMID- 22672913
OWN - NLM
STAT- MEDLINE
DCOM- 20121011
LR  - 20211021
IS  - 1349-9092 (Electronic)
IS  - 0917-5040 (Linking)
VI  - 22
IP  - 4
DP  - 2012
TI  - Asia Cohort Consortium: challenges for collaborative research.
PG  - 287-90
AB  - In this era of chronic diseases, large studies are essential in investigating
      genes, environment, and gene-environment interactions as disease causes,
      particularly when associations are important but not strong. Moreover, to allow
      expansion and generalization of the results, studies should be conducted in
      populations outside Western countries. Here, we briefly describe the Asia Cohort 
      Consortium (ACC), a collaborative cancer cohort research project that was first
      proposed in 2004 and now involves more than 1 million healthy individuals across 
      Asia. There are approximately 50 active members from Bangladesh, China, India,
      Japan, Korea, Malaysia, Singapore, Taiwan, Thailand, the United States, and
      elsewhere. To date, the work of the ACC includes 3 articles published in 2011 on 
      the roles of body mass index, tobacco smoking, and alcohol consumption in
      mortality, diabetes, and cancer of the small intestine. Many challenges remain,
      including data harmonization, resolution of ethical and legal issues,
      establishment of protocols for biologic samples and transfer agreements, and
      funding procurement.
FAU - Song, Minkyo
AU  - Song M
AD  - Department of Biomedical Sciences, Seoul National University College of Medicine,
      Seoul, Korea.
FAU - Rolland, Betsy
AU  - Rolland B
FAU - Potter, John D
AU  - Potter JD
FAU - Kang, Daehee
AU  - Kang D
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120510
PL  - Japan
TA  - J Epidemiol
JT  - Journal of epidemiology
JID - 9607688
SB  - IM
MH  - Asia
MH  - Biomedical Research/*organization & administration
MH  - Cohort Studies
MH  - *Cooperative Behavior
MH  - Forecasting
MH  - Humans
PMC - PMC3798645
EDAT- 2012/06/08 06:00
MHDA- 2012/10/12 06:00
CRDT- 2012/06/08 06:00
PHST- 2012/06/08 06:00 [entrez]
PHST- 2012/06/08 06:00 [pubmed]
PHST- 2012/10/12 06:00 [medline]
AID - DN/JST.JSTAGE/jea/JE20120024 [pii]
AID - 10.2188/jea.je20120024 [doi]
PST - ppublish
SO  - J Epidemiol. 2012;22(4):287-90. doi: 10.2188/jea.je20120024. Epub 2012 May 10.


PMID- 22672677
OWN - NLM
STAT- MEDLINE
DCOM- 20121012
LR  - 20120607
IS  - 1466-769X (Electronic)
IS  - 1466-7681 (Linking)
VI  - 13
IP  - 3
DP  - 2012 Jul
TI  - The holism of aesthetic knowing in nursing.
PG  - 179-88
LID - 10.1111/j.1466-769X.2012.00542.x [doi]
AB  - In 1978, Carper identified 'four fundamental patterns of knowing' that became
      largely foundational to subsequent epistemological discourse within the nursing
      discipline. These patterns of empirical, personal, aesthetic, and ethical knowing
      were presented as conceptually distinct yet related patterns of knowing. In order
      to provide an alternative conceptualization of aesthetics in nursing, the main
      tenants of Carper's discussion of aesthetic knowing will be revisited, and the
      foundations for her arguments will be examined. Specifically, Dewey's Art as
      Experience will be examined in relation to the 'holism' of nursing, and an
      alternative position on pragmatic aesthetics in nursing will be offered. A
      preliminary reintegration of the four patterns of knowing will then be presented 
      as will an example of a potential cultivation of aesthetics in nursing, through
      an example of Rodin's 19th century sculpture, the Burghers of Calais.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Archibald, Mandy M
AU  - Archibald MM
AD  - Faculty of Nursing, University of Alberta, Edmonton, AB, Canada. mma@ualberta.ca
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Philos
JT  - Nursing philosophy : an international journal for healthcare professionals
JID - 100897394
SB  - IM
MH  - Empathy
MH  - *Esthetics
MH  - *Holistic Nursing
MH  - Humans
MH  - Knowledge
MH  - *Nursing Care
MH  - Perception
EDAT- 2012/06/08 06:00
MHDA- 2012/10/13 06:00
CRDT- 2012/06/08 06:00
PHST- 2012/06/08 06:00 [entrez]
PHST- 2012/06/08 06:00 [pubmed]
PHST- 2012/10/13 06:00 [medline]
AID - 10.1111/j.1466-769X.2012.00542.x [doi]
PST - ppublish
SO  - Nurs Philos. 2012 Jul;13(3):179-88. doi: 10.1111/j.1466-769X.2012.00542.x.


PMID- 22672129
OWN - NLM
STAT- MEDLINE
DCOM- 20121227
LR  - 20220210
IS  - 1525-1403 (Electronic)
IS  - 1094-7159 (Linking)
VI  - 15
IP  - 4
DP  - 2012 Jul
TI  - Technological innovation in spinal cord stimulation: use of a newly developed
      delivery device for introduction of spinal cord stimulation leads.
PG  - 392-401
LID - 10.1111/j.1525-1403.2012.00461.x [doi]
AB  - OBJECTIVE: The use of multiple cylindrical leads and multicolumn and single
      column paddle leads in spinal cord stimulation offers many advantages over the
      use of a single cylindrical lead. Despite these advantages, placement of multiple
      cylindrical leads or a paddle lead requires a more invasive surgical procedure.
      Thus, the ideal situation for lead delivery would be percutaneous insertion of a 
      paddle lead or multiple cylindrical leads. This study evaluated the feasibility
      and safety of percutaneous delivery of S-Series paddle leads using a new delivery
      device called the Epiducer lead delivery system (all St. Jude Medical
      Neuromodulation Division, Plano, TX, USA). MATERIALS AND METHODS: This
      uncontrolled, open-label, prospective, two-center study approved by the AZ St.
      Lucas (Ghent) Ethics Committee evaluated procedural aspects of implantation of an
      S-Series paddle lead using the Epiducer lead delivery system and any adverse
      events relating to the device. Efficacy data during the patent's 30-day trial
      also were collected. RESULTS: Data from 34 patients were collected from two
      investigational sites. There were no adverse events related to the Epiducer lead 
      delivery system. The device was inserted at an angle of either 20 degrees -30
      degrees or 30 degrees -40 degrees and was entered into the epidural space at
      T12/L1 in most patients. The S-Series paddle lead was advanced four vertebral
      segments in more than 50% of patients. The average (+/-standard deviation [SD])
      time it took to place the Epiducer lead delivery system was 8.7 (+/-5.0) min. The
      average (+SD) patient-reported pain relief was 78.8% (+24.1%). CONCLUSIONS: This 
      study suggests the safe use of the Epiducer lead delivery system for percutaneous
      implantation and advancement of the S-Series paddle lead in 34 patients.
CI  - (c) 2012 International Neuromodulation Society.
FAU - Loge, David
AU  - Loge D
AD  - AZ St. Lucas, Ghent, Belgium. david.loge@telenet.be
FAU - De Coster, Olivier
AU  - De Coster O
FAU - Washburn, Stephanie
AU  - Washburn S
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20120601
PL  - United States
TA  - Neuromodulation
JT  - Neuromodulation : journal of the International Neuromodulation Society
JID - 9804159
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Electrodes, Implanted/adverse effects
MH  - Epidural Space/anatomy & histology/injuries/physiology
MH  - Equipment Design
MH  - Feasibility Studies
MH  - Female
MH  - Foreign-Body Migration
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pain Management/*methods
MH  - Pain Measurement
MH  - Patient Satisfaction
MH  - Prospective Studies
MH  - Prosthesis Implantation/*methods
MH  - Quality of Life
MH  - Spinal Cord/*physiology
MH  - Transcutaneous Electric Nerve Stimulation/adverse
      effects/*instrumentation/methods
EDAT- 2012/06/08 06:00
MHDA- 2012/12/28 06:00
CRDT- 2012/06/08 06:00
PHST- 2012/06/08 06:00 [entrez]
PHST- 2012/06/08 06:00 [pubmed]
PHST- 2012/12/28 06:00 [medline]
AID - 10.1111/j.1525-1403.2012.00461.x [doi]
AID - S1094-7159(21)01274-5 [pii]
PST - ppublish
SO  - Neuromodulation. 2012 Jul;15(4):392-401. doi: 10.1111/j.1525-1403.2012.00461.x.
      Epub 2012 Jun 1.


PMID- 22670648
OWN - NLM
STAT- MEDLINE
DCOM- 20121015
LR  - 20120607
IS  - 1468-4446 (Electronic)
IS  - 0007-1315 (Linking)
VI  - 63
IP  - 2
DP  - 2012 Jun
TI  - The bid, the lead-up, the event and the legacy: global cultural politics and
      hosting the Olympics.
PG  - 285-305
LID - 10.1111/j.1468-4446.2012.01410.x [doi]
AB  - Hosting mega sport events, especially the Olympics, demands an extensive
      engagement with global civil society given the voluntary, highly mediated
      exposure of host cities and nations to the world. The philosophy of Olympism
      requires ethical authority in demonstrating 'fitness' to host the Games, so
      demanding intensive strategic image management. Offensive and defensive
      mobilization of image-dependent 'species of power' in the field of sport (in a
      Bourdieusian sense) in conducting 'wars of position and movement' (following
      Gramsci) within global civil society are, then, crucial features of competitive
      manoeuvres around staging major sport events. The main empirical focus of this
      article is on the case of the Sydney 2000 ('Millennial') Games, in illustrating
      the socio-political dynamics of bidding and hosting in the context of a major
      civil societal matter of concern - Australia's continuing failure to achieve
      reconciliation with, and equality for, its indigenous peoples. Ironically,
      though, it was in the domain of human rights that Sydney had an advantage over
      its closest competitor in the 1993 bidding process - China. The strategies
      deployed to secure the consent of Australian Aborigines to the Games are
      addressed in analysing the means by which the Sydney 2000 Games avoided major
      disruption and international criticism. A second, briefer case analysis is then
      presented of the disputation concerning Beijing's successful bid for the 2008
      Olympics, which saw them influentially described by one (US) political activist
      as the 'Genocide Games' and the subject of international protests surrounding the
      Torch Relay. It is concluded that the contrasting levels of public, mediated
      discord in these two Olympiads in which human rights were key issues related,
      significantly though not exclusively, to the Chinese authorities' difficulties in
      'winning consent' through strategic incorporation of the most conspicuous,
      non-state oppositional forces within Western-dominated global civil society in
      its most immediate, unruly, and mediatized form.
CI  - (c) London School of Economics and Political Science 2012.
FAU - Rowe, David
AU  - Rowe D
AD  - Institute for Culture and Society, University of Western Sydney, Australia.
      d.rowe@uws.edu.au
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Sociol
JT  - The British journal of sociology
JID - 0373126
SB  - IM
MH  - China
MH  - Culture
MH  - Humans
MH  - International Cooperation
MH  - New South Wales
MH  - Politics
MH  - Social Control Policies
MH  - *Sports
EDAT- 2012/06/08 06:00
MHDA- 2012/10/16 06:00
CRDT- 2012/06/08 06:00
PHST- 2012/06/08 06:00 [entrez]
PHST- 2012/06/08 06:00 [pubmed]
PHST- 2012/10/16 06:00 [medline]
AID - 10.1111/j.1468-4446.2012.01410.x [doi]
PST - ppublish
SO  - Br J Sociol. 2012 Jun;63(2):285-305. doi: 10.1111/j.1468-4446.2012.01410.x.


PMID- 22670635
OWN - NLM
STAT- MEDLINE
DCOM- 20121011
LR  - 20220408
IS  - 1557-9034 (Electronic)
IS  - 1092-6429 (Linking)
VI  - 22
IP  - 5
DP  - 2012 Jun
TI  - Lessons learned from the first 100 laparoscopic liver resections: not delaying
      conversion may allow reduced blood loss and operative time.
PG  - 425-31
LID - 10.1089/lap.2011.0334 [doi]
AB  - BACKGROUND: The laparoscopic approach to liver resective surgery is slowly
      spreading to specialized centers. Little is known about factors influencing the
      immediate postoperative outcome. STUDY DESIGN: The purpose of the study was to
      evaluate the immediate outcome of laparoscopic liver resection (LLR), with
      particular emphasis on intraoperative bleeding and conversion. A retrospective
      analysis of demographic, clinical, and surgical data, including conversion,
      morbidity/mortality, and hospital stay, of the first 100 patients at our
      institution undergoing LLR from February 1997 through March 2007 was performed.
      RESULTS: Indication for LLR was benign lesion in 28 patients, malignancy in 33,
      and living donation in 39. Seventy-five resections involved two or more segments.
      Mean blood loss was 120 +/- 127.6 mL. One patient (1%) required transfusion. Mean
      operative time was 253 +/- 91.6 minutes. No patient died. Postoperative
      complications occurred in 21 patients. The conversion rate was 17%. Variables
      related to conversion were American Society of Anesthesiologists Class II, body
      mass index, cirrhosis, necessity for the Pringle maneuver, and intraoperative
      blood loss. Conversion did not influence the operative time. Patients with
      conversion had more complications and a longer hospital stay. CONCLUSIONS: Liver 
      resection by laparoscopy is feasible and safe, implying low intraoperative blood 
      loss. Not perfect physical conditions, cirrhosis, high body mass index, and,
      intraoperatively, blood loss and the necessity of a Pringle maneuver should be
      considered risk factors for conversion. A meticulous dissection by bipolar
      coagulation, Harmonic((R)) (Ethicon) scalpel, and ultrasound dissector, other
      than the attitude not to delay conversion in difficult cases, may allow for low
      blood loss without prolongation of operative time, with a possible, slight
      increase of the conversion rate.
FAU - Costi, Renato
AU  - Costi R
AD  - Department of Hepatobiliary Surgery and Liver Transplantation, Saint Antoine
      Hospital, Public Assistance Hospitals of Paris, University of Paris Pierre et
      Marie Curie, Paris, France .
FAU - Scatton, Olivier
AU  - Scatton O
FAU - Haddad, Luciana
AU  - Haddad L
FAU - Randone, Bruto
AU  - Randone B
FAU - Andraus, Wellington
AU  - Andraus W
FAU - Massault, Pierre-Philippe
AU  - Massault PP
FAU - Soubrane, Olivier
AU  - Soubrane O
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Laparoendosc Adv Surg Tech A
JT  - Journal of laparoendoscopic & advanced surgical techniques. Part A
JID - 9706293
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Loss, Surgical/*prevention & control
MH  - Female
MH  - Hepatectomy/adverse effects/*methods
MH  - Humans
MH  - Laparoscopy
MH  - Liver Diseases/*surgery
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Time Factors
MH  - Young Adult
EDAT- 2012/06/08 06:00
MHDA- 2012/10/12 06:00
CRDT- 2012/06/08 06:00
PHST- 2012/06/08 06:00 [entrez]
PHST- 2012/06/08 06:00 [pubmed]
PHST- 2012/10/12 06:00 [medline]
AID - 10.1089/lap.2011.0334 [doi]
PST - ppublish
SO  - J Laparoendosc Adv Surg Tech A. 2012 Jun;22(5):425-31. doi:
      10.1089/lap.2011.0334.


PMID- 22670493
OWN - NLM
STAT- MEDLINE
DCOM- 20120622
LR  - 20120607
IS  - 0017-7768 (Print)
IS  - 0017-7768 (Linking)
VI  - 151
IP  - 1
DP  - 2012 Jan
TI  - [Physicians' strikes--ethical considerations].
PG  - 12-5, 63
AB  - Strikes in general represent a solution based on a form of coercion.
      Historically, the striker caused direct damage to his employer, who was
      responsible for the perceived unfair treatment of the employee. In the case of
      strikes in the public sector, the employer is generally not harmed, but innocent 
      citizens suffer in order to pressure the government agencies, a questionable
      practice from an ethical viewpoint. Physicians' strikes have more serious ethical
      problems. They cause suffering and death to innocent citizens. They violate the
      ethical codes to which physicians have committed themselves as professionals, and
      they seriously impair the trust of the public in physicians. Better and more
      ethical ways to provide fair compensation for physicians must be employed,
      perhaps like those used for judges and members of the IDF.
FAU - Glick, Shimon
AU  - Glick S
AD  - Rabbi Immanuel Jakobovits Center for Jewish Medical Ethics, Faculty of Health
      Sciences, Ben Gurion University of the Negev. gshimon@bgu.ac.il
FAU - Schwarzfuchs, Dan
AU  - Schwarzfuchs D
LA  - heb
PT  - English Abstract
PT  - Journal Article
PL  - Israel
TA  - Harefuah
JT  - Harefuah
JID - 0034351
SB  - IM
MH  - *Ethics, Medical
MH  - Humans
MH  - Israel
MH  - Physicians/ethics/*organization & administration
MH  - Social Responsibility
MH  - Strikes, Employee/*ethics
EDAT- 2012/06/08 06:00
MHDA- 2012/06/23 06:00
CRDT- 2012/06/08 06:00
PHST- 2012/06/08 06:00 [entrez]
PHST- 2012/06/08 06:00 [pubmed]
PHST- 2012/06/23 06:00 [medline]
PST - ppublish
SO  - Harefuah. 2012 Jan;151(1):12-5, 63.


PMID- 22648671
OWN - NLM
STAT- MEDLINE
DCOM- 20121128
LR  - 20211021
IS  - 1525-1497 (Electronic)
IS  - 0884-8734 (Linking)
VI  - 27 Suppl 1
DP  - 2012 Jun
TI  - Chapter 3: choosing the important outcomes for a systematic review of a medical
      test.
PG  - S20-7
LID - 10.1007/s11606-011-1802-x [doi]
AB  - In this chapter of the Evidence-based Practice Centers Methods Guide for Medical 
      Tests, we describe how the decision to use a medical test generates a broad range
      of outcomes and that each of these outcomes should be considered for inclusion in
      a systematic review. Awareness of these varied outcomes affects how a decision
      maker balances the benefits and risks of the test; therefore, a systematic review
      should present the evidence on these diverse outcomes. The key outcome categories
      include clinical management outcomes and direct health effects; emotional,
      social, cognitive, and behavioral responses to testing; legal and ethical
      outcomes, and costs. We describe the challenges of incorporating these outcomes
      in a systematic review, suggest a framework for generating potential outcomes for
      inclusion, and describe the role of stakeholders in choosing the outcomes for
      study. Finally, we give examples of systematic reviews that either included a
      range of outcomes or that might have done so. The following are the key messages 
      in this chapter: Consider both the outcomes that are relevant to the process of
      testing and those that are relevant to the results of the test. Consider
      inclusion of outcomes in all five domains: clinical management effects, direct
      test effects; emotional, social, cognitive and behavioral effects; legal and
      ethical effects, and costs. Consider to which group the outcomes of testing are
      most relevant. Given resource limitations, prioritize which outcomes to include. 
      This decision depends on the needs of the stakeholder(s), who should be assisted 
      in prioritizing the outcomes for inclusion.
FAU - Segal, Jodi B
AU  - Segal JB
AD  - Johns Hopkins University School of Medicine, 1830 E. Monument St., Baltimore, MD 
      21287, USA. jsegal@jhmi.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Gen Intern Med
JT  - Journal of general internal medicine
JID - 8605834
SB  - IM
MH  - Decision Making
MH  - Diagnostic Techniques and Procedures/adverse effects/*standards
MH  - Evidence-Based Medicine/methods/standards
MH  - *Guidelines as Topic
MH  - Humans
MH  - Outcome and Process Assessment, Health Care/*methods/standards
MH  - *Review Literature as Topic
MH  - Risk Assessment/methods
PMC - PMC3364352
EDAT- 2012/06/08 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/06/01 06:00
PHST- 2012/06/01 06:00 [entrez]
PHST- 2012/06/08 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1007/s11606-011-1802-x [doi]
PST - ppublish
SO  - J Gen Intern Med. 2012 Jun;27 Suppl 1:S20-7. doi: 10.1007/s11606-011-1802-x.


PMID- 22669667
OWN - NLM
STAT- MEDLINE
DCOM- 20120924
LR  - 20120606
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Linking)
VI  - 889
DP  - 2012
TI  - Rodent whole embryo culture.
PG  - 215-37
LID - 10.1007/978-1-61779-867-2_13 [doi]
AB  - The direct effects of chemical exposures, environmental extremes, and nutrient
      quality/quantity have been very difficult to study in mammalian embryos due to
      their anatomical inaccessibility, paucity of tissues, and other factors such as
      real ethical concerns in human studies. Many acute and chronic developmental
      anomalies can trace their origins to postimplantation phases of gestation where
      the organs are first being established and growth and differentiation are in
      highly active states of flux. Most agents and conditions that produce birth
      defects are believed to act during this period of organogenesis. The evolution of
      rodent whole embryo culture (WEC) techniques has provided a valuable experimental
      model where physiological conditions and exposures can be carefully controlled
      and manipulated to test hypotheses and explore biochemical and molecular
      mechanisms of action. Exposure to chemical agents can be controlled through their
      direct addition to the culture medium. Optimal in vitro culture conditions
      support the growth of intact, viable conceptuses (embryo and associated
      extraembryonic membranes) from early egg cylinder stages through establishment of
      the neural plate, gastrulation, neural tube closure, onset of active heartbeat
      and circulation, and the initial formation of all major organ systems that occur 
      prior to the establishment of a functional placenta. Detailed comparisons of in
      vivo and in vitro growth show that conceptuses grown in WEC are nearly identical,
      structurally and functionally, to conceptuses of the same developmental stage
      that are allowed to develop normally in vivo. Culture conditions and mechanical
      apparatus can be modified to suit a large number of different experimental
      approaches and paradigms.
FAU - Harris, Craig
AU  - Harris C
AD  - Toxicology Program, Department of Environmental Health Sciences, University of
      Michigan, Ann Arbor, MI, USA. charris@umich.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
RN  - 0 (Proteins)
SB  - IM
MH  - Animal Husbandry
MH  - Animals
MH  - *Embryo Culture Techniques
MH  - Embryo, Mammalian/anatomy & histology/drug effects/metabolism
MH  - Female
MH  - Male
MH  - Mice
MH  - Proteins/chemistry
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Research Design
MH  - Toxicity Tests/methods
MH  - Yolk Sac/blood supply/metabolism
EDAT- 2012/06/07 06:00
MHDA- 2012/09/25 06:00
CRDT- 2012/06/07 06:00
PHST- 2012/06/07 06:00 [entrez]
PHST- 2012/06/07 06:00 [pubmed]
PHST- 2012/09/25 06:00 [medline]
AID - 10.1007/978-1-61779-867-2_13 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2012;889:215-37. doi: 10.1007/978-1-61779-867-2_13.


PMID- 22669655
OWN - NLM
STAT- MEDLINE
DCOM- 20120924
LR  - 20120606
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Linking)
VI  - 889
DP  - 2012
TI  - Developmental toxicology: methods and protocols. Volume overview: introduction.
PG  - 1-5
LID - 10.1007/978-1-61779-867-2_1 [doi]
AB  - The origins and history of the study of teratology and developmental toxicology
      span centuries of human experience. Anatomical malformations observed at birth
      have been described across many generations but the root causes of these events
      have been enigmatic and difficult to understand. Many factors may contribute to
      the lack of mechanistic understanding, but the miniscule size, inaccessibility,
      and the consequences of ethical concerns contribute heavily to the unique
      restrictions on developmental toxicology research. Classic teratogens, such as
      vitamin A, Rubella virus, thalidomide, and methyl mercury, have provided many
      insights into understanding the modes of chemical action that are responsible for
      causing defects but the specific mechanisms remain unclear. Developmental
      toxicology research has benefitted greatly in the past decades from discoveries
      made in related fields of study, including those from cancer research, stem cell 
      biology, and developmental biology. New methods created and adapted for studies
      in developmental toxicology have taken on greater importance as gestational
      lesions can now be shown to have developmental and health consequences across the
      entire lifespan.
FAU - Harris, Craig
AU  - Harris C
AD  - Toxicology Program, Department of Environmental Health Sciences, University of
      Michigan, Ann Arbor, MI, USA. charris@umich.edu
LA  - eng
PT  - Introductory Journal Article
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
SB  - IM
MH  - Animals
MH  - Congenital Abnormalities/*etiology
MH  - Developmental Biology
MH  - Environmental Exposure
MH  - Female
MH  - Humans
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*etiology
MH  - Prenatal Nutritional Physiological Phenomena
MH  - Teratology
MH  - Toxicity Tests/methods
EDAT- 2012/06/07 06:00
MHDA- 2012/09/25 06:00
CRDT- 2012/06/07 06:00
PHST- 2012/06/07 06:00 [entrez]
PHST- 2012/06/07 06:00 [pubmed]
PHST- 2012/09/25 06:00 [medline]
AID - 10.1007/978-1-61779-867-2_1 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2012;889:1-5. doi: 10.1007/978-1-61779-867-2_1.


PMID- 22669341
OWN - NLM
STAT- MEDLINE
DCOM- 20131114
LR  - 20211021
IS  - 2193-6226 (Electronic)
IS  - 2193-6218 (Linking)
VI  - 107
IP  - 7
DP  - 2012 Oct
TI  - [Ethic rounds in intensive care. Possible instrument for a clinical-ethical
      assessment in intensive care units].
PG  - 553-7
LID - 10.1007/s00063-012-0110-5 [doi]
AB  - Ethical problems, such as medical end-of-life decisions or withdrawing
      life-sustaining treatment are viewed as an essential task in intensive care
      units. This article presents the ethics rounds as an instrument for evaluation of
      ethical problems in intensive care medicine units. The benchmarks of ethical
      reflection during the ethics rounds are considerations of ethical theory of
      principle-oriented medical ethics. Besides organizational aspects and the
      institutional framework, the role of the ethicist is described. The essential
      evaluation steps, as a basis of the ethics rounds are presented. In contrast to
      the clinical ethics consultation, the ethicist in the ethics rounds model is
      integrated as a member of the ward round team. Therefore ethical problems may be 
      identified and analyzed very early before the conflict escalates. This preventive
      strategy makes the ethics rounds a helpful instrument in intensive care units.
FAU - Scheffold, N
AU  - Scheffold N
AD  - Medizinische Klinik I, Klinikum Memmingen, Bismarkstrasse 23, Memmingen, Germany.
      norbert.scheffold@klinikum-memmingen.de
FAU - Paoli, A
AU  - Paoli A
FAU - Gross, J
AU  - Gross J
FAU - Riemann, U
AU  - Riemann U
FAU - Hennersdorf, M
AU  - Hennersdorf M
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Ethikvisite auf der Intensivstation. Mogliches Instrument einer
      klinisch-ethischen Standortbestimmung in der Intensivmedizin.
DEP - 20120607
PL  - Germany
TA  - Med Klin Intensivmed Notfmed
JT  - Medizinische Klinik, Intensivmedizin und Notfallmedizin
JID - 101575086
SB  - IM
MH  - Advance Directives/ethics
MH  - Ethics, Medical
MH  - Humans
MH  - Intensive Care Units/*ethics
MH  - Life Support Care/ethics
MH  - Patient Care Team
MH  - Referral and Consultation/ethics
MH  - Withholding Treatment/ethics
EDAT- 2012/06/07 06:00
MHDA- 2013/11/15 06:00
CRDT- 2012/06/07 06:00
PHST- 2011/10/27 00:00 [received]
PHST- 2012/02/28 00:00 [accepted]
PHST- 2012/01/26 00:00 [revised]
PHST- 2012/06/07 06:00 [entrez]
PHST- 2012/06/07 06:00 [pubmed]
PHST- 2013/11/15 06:00 [medline]
AID - 10.1007/s00063-012-0110-5 [doi]
PST - ppublish
SO  - Med Klin Intensivmed Notfmed. 2012 Oct;107(7):553-7. doi:
      10.1007/s00063-012-0110-5. Epub 2012 Jun 7.


PMID- 22669238
OWN - NLM
STAT- MEDLINE
DCOM- 20121023
LR  - 20150127
IS  - 1559-6834 (Electronic)
IS  - 0899-823X (Linking)
VI  - 33
IP  - 7
DP  - 2012 Jul
TI  - Prospective approach to managing antimicrobial drug shortages.
PG  - 745-52
LID - 10.1086/666332 [doi]
AB  - Antimicrobial drug shortages continue to increase, with few new therapeutic
      options available. Nationally, proposals have been offered to alleviate drug
      shortages; however, these recommendations are unlikely to effect change in the
      near future. Thus, antimicrobial stewardship leaders in acute care hospitals must
      develop a prospective management strategy to lessen the impact of these shortages
      on patient care. Herein, we describe several resources available to aid
      professionals in antimicrobial stewardship and healthcare epidemiology to manage 
      drug shortages. An effective approach should include prospectively tracking
      shortages and maximizing inventory by appropriately managing usage. Several
      tenets should underpin this management. Alternative agents should be rationally
      chosen before the inventory of the primary agent has reached zero, ethical
      considerations should be taken into account, and timely notification and
      communication with key stakeholders should occur throughout the prescribing and
      dispensing process.
FAU - Griffith, Milena M
AU  - Griffith MM
AD  - Department of Pharmacy Practice, Midwestern University Chicago College of
      Pharmacy, Downers Grove, IL 60515, USA.
FAU - Patel, Jean A
AU  - Patel JA
FAU - Sutton, Sarah H
AU  - Sutton SH
FAU - Bolon, Maureen K
AU  - Bolon MK
FAU - Esterly, John S
AU  - Esterly JS
FAU - Gross, Alan E
AU  - Gross AE
FAU - Postelnick, Michael J
AU  - Postelnick MJ
FAU - Zembower, Teresa R
AU  - Zembower TR
FAU - Scheetz, Marc H
AU  - Scheetz MH
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120518
PL  - United States
TA  - Infect Control Hosp Epidemiol
JT  - Infection control and hospital epidemiology
JID - 8804099
RN  - 0 (Anti-Infective Agents)
SB  - IM
MH  - Anti-Infective Agents/*supply & distribution
MH  - Humans
MH  - Pharmacy Service, Hospital/*organization & administration
EDAT- 2012/06/07 06:00
MHDA- 2012/10/24 06:00
CRDT- 2012/06/07 06:00
PHST- 2012/06/07 06:00 [entrez]
PHST- 2012/06/07 06:00 [pubmed]
PHST- 2012/10/24 06:00 [medline]
AID - 10.1086/666332 [doi]
PST - ppublish
SO  - Infect Control Hosp Epidemiol. 2012 Jul;33(7):745-52. doi: 10.1086/666332. Epub
      2012 May 18.


PMID- 22668949
OWN - NLM
STAT- MEDLINE
DCOM- 20120821
LR  - 20191027
IS  - 0256-9574 (Print)
VI  - 102
IP  - 6
DP  - 2012 Mar 2
TI  - The prevalence and burden of pain and other symptoms among South Africans
      attending highly active antiretroviral therapy (HAART) clinics.
PG  - 499-500
AB  - BACKGROUND: Since the advent of antiretrovirals, HIV disease has largely come to 
      be considered a chronic disease for those able to access treatment. As such, the 
      concept of 'living well' with HIV is important. Increasing evidence suggests a
      high symptom burden in HIV that persists in the presence of treatment.
      OBJECTIVES: Our study aimed to measure the prevalence and burden of pain and
      other physical and psychological symptoms among South African HIV-positive
      patients attending highly active antiretroviral therapy (HAART) clinics. METHODS:
      The study design was a cross-sectional survey. Simple random sampling was used to
      recruit 385 adult participants. RESULTS: The sample had a median age of 40 years 
      (Q1 - Q3=33 - 46) and 98.4% were on HAART. The mean latest CD4 count for the
      participants was 355.06+/-219/mm(3). The mean number of symptoms of the 32
      symptoms on the MSAS-SF experienced by participants was 10.24+/-5.71 (range 1 -
      28). All 4 psychological symptoms were in the top 10 most prevalent symptoms,
      with feeling sad being the most prevalent symptom overall. CONCLUSIONS: The high 
      prevalence of symptoms and the high symptom burden experienced by the
      participants in this survey suggest inadequate symptom control and highlight the 
      palliative care needs of an ambulant patient population already on HAART.
      Extension of life without reasonable efforts to also address the patient's
      quality of life is not ethically justifiable. In addition, more research appears 
      to be required to answer whether these findings are associated with sub-optimal
      HAART adherence.
FAU - Farrant, Lindsay
AU  - Farrant L
AD  - Palliative Medicine Unit, School of Public Health and Family Medicine, University
      of Cape Town. lindsaygfarrant@gmail.com
FAU - Gwyther, Liz
AU  - Gwyther L
FAU - Dinat, Natalya
AU  - Dinat N
FAU - Mmoledi, Keletso
AU  - Mmoledi K
FAU - Hatta, Ntombi
AU  - Hatta N
FAU - Harding, Richard
AU  - Harding R
LA  - eng
PT  - Journal Article
DEP - 20120302
PL  - South Africa
TA  - S Afr Med J
JT  - South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
JID - 0404520
SB  - IM
MH  - Adult
MH  - Antiretroviral Therapy, Highly Active
MH  - Anxiety/epidemiology/therapy
MH  - CD4 Lymphocyte Count
MH  - Cross-Sectional Studies
MH  - Depression/epidemiology/therapy
MH  - Female
MH  - HIV Infections/*complications/drug therapy/*psychology
MH  - Humans
MH  - Irritable Mood
MH  - Male
MH  - Middle Aged
MH  - Pain/*epidemiology
MH  - Pain Management
MH  - *Palliative Care
MH  - Quality of Life
MH  - Self Report
MH  - South Africa/epidemiology
EDAT- 2012/06/07 06:00
MHDA- 2012/08/22 06:00
CRDT- 2012/06/07 06:00
PHST- 2011/11/24 00:00 [received]
PHST- 2012/01/23 00:00 [accepted]
PHST- 2012/06/07 06:00 [entrez]
PHST- 2012/06/07 06:00 [pubmed]
PHST- 2012/08/22 06:00 [medline]
AID - 10.7196/samj.5481 [doi]
PST - epublish
SO  - S Afr Med J. 2012 Mar 2;102(6):499-500. doi: 10.7196/samj.5481.


PMID- 22668844
OWN - NLM
STAT- MEDLINE
DCOM- 20121106
LR  - 20151119
IS  - 1486-3847 (Print)
IS  - 1486-3847 (Linking)
VI  - 73
IP  - 2
DP  - 2012 Summer
TI  - Dietitians and eating disorders: an international issue.
PG  - 86-90
AB  - The prevalence of eating disorders is higher in university nutrition faculties
      than in other faculties. We examined beliefs about and approaches to eating
      disorders in nutrition education faculties around the world. We developed a
      questionnaire specifically for this project and distributed 664 copies
      electronically, using contact information obtained in collaboration with
      Dietitians of Canada and the International Confederation of Dietetic
      Associations. Using the 101 questionnaires returned from 14 countries, we found
      that 77% of respondents felt eating disorders are a concern among nutrition
      students; however, only 15% of programs had policies/procedures to help address
      these disorders. Forty-eight percent of respondents thought screening for eating 
      disorders would be a good idea; however, 78% of them believed screening would
      involve ethical issues. In conclusion, eating disorders are a concern in
      nutrition faculties around the world, and while most feel something should be
      done, ethical dilemmas contribute to confusion over the best approach. More work 
      is needed in this area.
FAU - Drummond, Dianne
AU  - Drummond D
AD  - Alberta Health Services, Edmonton, AB.
FAU - Hare, M Suzanne
AU  - Hare MS
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can J Diet Pract Res
JT  - Canadian journal of dietetic practice and research : a publication of Dietitians 
      of Canada = Revue canadienne de la pratique et de la recherche en dietetique :
      une publication des Dietetistes du Canada
JID - 9811151
SB  - IM
MH  - Counseling/*methods
MH  - Dietetics/*methods
MH  - Feeding and Eating Disorders/*diet therapy/*epidemiology
MH  - Health Education
MH  - Health Services Research
MH  - Humans
MH  - Interviews as Topic
MH  - Statistics as Topic
MH  - Students
MH  - Surveys and Questionnaires
EDAT- 2012/06/07 06:00
MHDA- 2012/11/07 06:00
CRDT- 2012/06/07 06:00
PHST- 2012/06/07 06:00 [entrez]
PHST- 2012/06/07 06:00 [pubmed]
PHST- 2012/11/07 06:00 [medline]
AID - 10.3148/73.2.2012.86 [doi]
PST - ppublish
SO  - Can J Diet Pract Res. 2012 Summer;73(2):86-90. doi: 10.3148/73.2.2012.86.


PMID- 22668586
OWN - NLM
STAT- MEDLINE
DCOM- 20140627
LR  - 20120724
IS  - 1873-233X (Electronic)
IS  - 0029-7844 (Linking)
VI  - 120
IP  - 2 Pt 1
DP  - 2012 Aug
TI  - Building a better safety net: taking the safety agenda to office-based women's
      health.
PG  - 355-9
LID - 10.1097/AOG.0b013e318260957c [doi]
AB  - The recent focus on health care safety is a response to the central ethical tenet
      of medicine--to do no harm. The delivery of safe hospital care has led to
      demonstrable reductions in medical errors, adverse events, and patient injuries. 
      These improvements have led to a commensurate reduction of legal risk and the
      emotional toll on caregivers as well as families. It also has reinvigorated the
      reason many physicians went into medicine--to make a difference for women's
      health. The new, voluntary Safety Certification in Outpatient Practice Excellence
      (SCOPE) for Women's Health program of the American Congress of Obstetricians and 
      Gynecologists is a means to both evaluate and recognize work in a critical but
      often neglected arena--the outpatient setting. It builds on infrastructure
      created for safety programs in hospital settings. Strong physician leadership,
      the development of an office culture committed to safety, communication and
      teamwork skills, safety programs for office-based surgery, medication safety, and
      tracking systems are all important for safe treatment of our patients in the
      office setting. The SCOPE Program defines the necessary safety goals for
      ambulatory women's health care and provides an educational pathway to reach those
      goals. SCOPE certification is an achievement recognizing the commitment of
      physicians and their staff to the health and safety of their patients.
FAU - Sclafani, Joseph
AU  - Sclafani J
AD  - New York Methodist Hospital and the Department of Obstetrics and Gynecology,
      Weill Cornell Medical College, New York, New York, USA.
FAU - Levy, Barbara
AU  - Levy B
FAU - Lawrence, Hal
AU  - Lawrence H
FAU - Saraco, Mindy
AU  - Saraco M
FAU - Cain, Joanna M
AU  - Cain JM
LA  - eng
PT  - Editorial
PL  - United States
TA  - Obstet Gynecol
JT  - Obstetrics and gynecology
JID - 0401101
SB  - IM
EIN - Obstet Gynecol. 2012 Oct;120(4):957
MH  - Ambulatory Care/standards
MH  - Female
MH  - Gynecology/organization & administration
MH  - Humans
MH  - Obstetrics/organization & administration
MH  - *Patient Safety
MH  - Women's Health/*standards
EDAT- 2012/06/07 06:00
MHDA- 2014/06/28 06:00
CRDT- 2012/06/07 06:00
PHST- 2012/06/07 06:00 [entrez]
PHST- 2012/06/07 06:00 [pubmed]
PHST- 2014/06/28 06:00 [medline]
AID - 10.1097/AOG.0b013e318260957c [doi]
PST - ppublish
SO  - Obstet Gynecol. 2012 Aug;120(2 Pt 1):355-9. doi: 10.1097/AOG.0b013e318260957c.


PMID- 22668564
OWN - NLM
STAT- MEDLINE
DCOM- 20121024
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 264
IP  - 2
DP  - 2012 Aug
TI  - Reducing error and improving efficiency during vascular interventional radiology:
      implementation of a preprocedural team rehearsal.
PG  - 473-83
LID - 10.1148/radiol.12110530 [doi]
AB  - PURPOSE: To determine the type and frequency of errors during vascular
      interventional radiology (VIR) and design and implement an intervention to reduce
      error and improve efficiency in this setting. MATERIALS AND METHODS: Ethical
      guidance was sought from the Research Services Department at Imperial College
      London. Informed consent was not obtained. Field notes were recorded during 55
      VIR procedures by a single observer. Two blinded assessors identified failures
      from field notes and categorized them into one or more errors by using a 22-part 
      classification system. The potential to cause harm, disruption to procedural
      flow, and preventability of each failure was determined. A preprocedural team
      rehearsal (PPTR) was then designed and implemented to target frequent preventable
      potential failures. Thirty-three procedures were observed subsequently to
      determine the efficacy of the PPTR. Nonparametric statistical analysis was used
      to determine the effect of intervention on potential failure rates, potential to 
      cause harm and procedural flow disruption scores (Mann-Whitney U test), and
      number of preventable failures (Fisher exact test). RESULTS: Before intervention,
      1197 potential failures were recorded, of which 54.6% were preventable. A total
      of 2040 errors were deemed to have occurred to produce these failures. Planning
      error (19.7%), staff absence (16.2%), equipment unavailability (12.2%),
      communication error (11.2%), and lack of safety consciousness (6.1%) were the
      most frequent errors, accounting for 65.4% of the total. After intervention, 352 
      potential failures were recorded. Classification resulted in 477 errors.
      Preventable failures decreased from 54.6% to 27.3% (P < .001) with implementation
      of PPTR. Potential failure rates per hour decreased from 18.8 to 9.2 (P < .001), 
      with no increase in potential to cause harm or procedural flow disruption per
      failure. CONCLUSION: Failures during VIR procedures are largely because of
      ineffective planning, communication error, and equipment difficulties, rather
      than a result of technical or patient-related issues. Many of these potential
      failures are preventable. A PPTR is an effective means of targeting frequent
      preventable failures, reducing procedural delays and improving patient safety.
FAU - Morbi, Abigail H M
AU  - Morbi AH
AD  - Department of Surgery and Cancer, Imperial College, St Mary's Hospital, London,
      England.
FAU - Hamady, Mohamad S
AU  - Hamady MS
FAU - Riga, Celia V
AU  - Riga CV
FAU - Kashef, Elika
AU  - Kashef E
FAU - Pearch, Ben J
AU  - Pearch BJ
FAU - Vincent, Charles
AU  - Vincent C
FAU - Moorthy, Krishna
AU  - Moorthy K
FAU - Vats, Amit
AU  - Vats A
FAU - Cheshire, Nicholas J W
AU  - Cheshire NJ
FAU - Bicknell, Colin D
AU  - Bicknell CD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120605
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Efficiency
MH  - Female
MH  - Humans
MH  - Male
MH  - Medical Errors/*prevention & control
MH  - Patient Care Team/*organization & administration
MH  - Patient Safety
MH  - Radiography, Interventional/*methods
MH  - Statistics, Nonparametric
MH  - Time Factors
MH  - Treatment Outcome
MH  - Vascular Diseases/*diagnostic imaging/*therapy
EDAT- 2012/06/07 06:00
MHDA- 2012/10/25 06:00
CRDT- 2012/06/07 06:00
PHST- 2012/06/07 06:00 [entrez]
PHST- 2012/06/07 06:00 [pubmed]
PHST- 2012/10/25 06:00 [medline]
AID - radiol.12110530 [pii]
AID - 10.1148/radiol.12110530 [doi]
PST - ppublish
SO  - Radiology. 2012 Aug;264(2):473-83. doi: 10.1148/radiol.12110530. Epub 2012 Jun 5.


PMID- 22668562
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20120622
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 264
IP  - 1
DP  - 2012 Jul
TI  - Subacute default mode network dysfunction in the prediction of post-stroke
      depression severity.
PG  - 218-24
LID - 10.1148/radiol.12111718 [doi]
AB  - PURPOSE: To identify patterns of rest functional connectivity (FC) in the whole
      brain with the default mode network (DMN) soon after stroke and to explore the
      predictive accuracy of the strength of rest FC in specific areas on poststroke
      severity of depression and anxiety symptoms. MATERIALS AND METHODS: The protocol 
      was accepted by the local ethics board, and all patients provided informed
      consent to participate. Resting-state functional magnetic resonance (MR) images
      were acquired 10 days after a first stroke in 24 patients without a history of
      psychiatric illness. Independent component analysis was used to isolate the DMN
      in each subject. Hamilton Depression Rating Scale (HDRS) 17 and Hamilton Anxiety 
      Rating Scale (HARS) were recorded 10 days and 3 months after the stroke.
      Associations between severity of anxiety or depression symptoms and DMN
      functional connectivity were investigated with whole-brain analyses by using
      statistical parametric mapping software and were adjusted for age, sex, manual
      laterality, and National Institutes of Health Stroke Severity scores.
      Correlations were considered significant if P<.001, with a cluster size of more
      than 50 voxels. RESULTS: Ten days after stroke, anxiety severity was correlated
      with functional connectivity in the middle temporal cortex and the anterior
      midcingulate cortex, while at 3 months after stroke, a correlation was observed
      with the middle temporal cortex and the posterior cingulate cortex. Poststroke
      depressive symptom severity did not correlate with functional connectivity
      changes at 10-day follow-up, while the HDRS 17 score was correlated with
      functional connectivity in the left middle temporal cortex and precuneus at
      3-month follow-up. CONCLUSION: These results suggest that a dysfunction of DMN
      functional connectivity involved in emotional control is associated with the
      severity of poststroke depression. Further studies are necessary to determine the
      mechanisms of this functional impairment.
CI  - (c) RSNA, 2012.
FAU - Lassalle-Lagadec, Saioa
AU  - Lassalle-Lagadec S
AD  - Universite Bordeaux2, Department of Clinical Neurosciences, CHU Bordeaux, Hopital
      Pellegrin, Place Amelie Raba-Leon, 33076 Bordeaux, France.
FAU - Sibon, Igor
AU  - Sibon I
FAU - Dilharreguy, Bixente
AU  - Dilharreguy B
FAU - Renou, Pauline
AU  - Renou P
FAU - Fleury, Olivier
AU  - Fleury O
FAU - Allard, Michele
AU  - Allard M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120605
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Brain Mapping/*methods
MH  - Cerebrovascular Circulation
MH  - Depression/*physiopathology/*psychology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Neural Pathways/physiopathology
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Psychiatric Status Rating Scales
MH  - Severity of Illness Index
MH  - Stroke/*physiopathology/*psychology
EDAT- 2012/06/07 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/06/07 06:00
PHST- 2012/06/07 06:00 [entrez]
PHST- 2012/06/07 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
AID - radiol.12111718 [pii]
AID - 10.1148/radiol.12111718 [doi]
PST - ppublish
SO  - Radiology. 2012 Jul;264(1):218-24. doi: 10.1148/radiol.12111718. Epub 2012 Jun 5.


PMID- 22667005
OWN - NLM
STAT- MEDLINE
DCOM- 20120719
LR  - 20120606
IS  - 1092-0811 (Print)
IS  - 1092-0811 (Linking)
VI  - 21
IP  - 2
DP  - 2012 Mar-Apr
TI  - Applying the ethics of care to your nursing practice.
PG  - 112-4, 116
FAU - Lachman, Vicki D
AU  - Lachman VD
AD  - Drexel University, College of Nursing and Health Professions, Philadelphia, PA,
      USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medsurg Nurs
JT  - Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses
JID - 9300545
MH  - Abdominal Pain/nursing
MH  - *Empathy
MH  - Ethical Theory
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nursing Care/*ethics
MH  - *Patient Advocacy
EDAT- 2012/06/07 06:00
MHDA- 2012/07/20 06:00
CRDT- 2012/06/07 06:00
PHST- 2012/06/07 06:00 [entrez]
PHST- 2012/06/07 06:00 [pubmed]
PHST- 2012/07/20 06:00 [medline]
PST - ppublish
SO  - Medsurg Nurs. 2012 Mar-Apr;21(2):112-4, 116.


PMID- 22666157
OWN - NLM
STAT- MEDLINE
DCOM- 20121026
LR  - 20211021
IS  - 1537-744X (Electronic)
IS  - 1537-744X (Linking)
VI  - 2012
DP  - 2012
TI  - Prosocial norms as a positive youth development construct: a conceptual review.
PG  - 832026
LID - 10.1100/2012/832026 [doi]
AB  - Prosocial norms like reciprocity, social responsibility, altruism, and
      volunteerism are ethical standards and beliefs that youth development programs
      often want to promote. This paper reviews evolutionary, social-cognitive, and
      developmental theories of prosocial development and analyzes how young people
      learn and adopt prosocial norms. The paper showed that very few current theories 
      explicitly address the issue of how prosocial norms, in form of feelings of moral
      obligations, may be challenged by a norm of self-interest and social
      circumstances when prosocial acts are needed. It is necessary to develop theories
      which put prosocial norms as a central construct, and a new social cognitive
      theory of norm activation has the potential to help us understand how prosocial
      norms may be applied. This paper also highlights how little we know about young
      people perceiving and receiving prosocial norms and how influential of school
      policies and peer influence on the prosocial development. Lastly, while training 
      of interpersonal competence (e.g., empathy, moral reasoning, etc.) was commonly
      used in the youth development, their effectiveness was not systematically
      evaluated. It will also be interesting to examine how computer and information
      technology or video games may be used in e-learning of prosocial norms.
FAU - Siu, Andrew M H
AU  - Siu AM
AD  - Department of Rehabilitation Science, The Hong Kong Polytechnic University, Hong 
      Kong.
FAU - Shek, Daniel T L
AU  - Shek DT
FAU - Law, Ben
AU  - Law B
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120501
PL  - United States
TA  - ScientificWorldJournal
JT  - TheScientificWorldJournal
JID - 101131163
SB  - IM
MH  - Adolescent
MH  - *Adolescent Behavior
MH  - Cognition
MH  - Humans
PMC - PMC3361333
EDAT- 2012/06/06 06:00
MHDA- 2012/10/27 06:00
CRDT- 2012/06/06 06:00
PHST- 2011/08/15 00:00 [received]
PHST- 2011/09/20 00:00 [accepted]
PHST- 2012/06/06 06:00 [entrez]
PHST- 2012/06/06 06:00 [pubmed]
PHST- 2012/10/27 06:00 [medline]
AID - 10.1100/2012/832026 [doi]
PST - ppublish
SO  - ScientificWorldJournal. 2012;2012:832026. doi: 10.1100/2012/832026. Epub 2012 May
      1.


PMID- 22665816
OWN - NLM
STAT- MEDLINE
DCOM- 20120813
LR  - 20130625
IS  - 1539-3704 (Electronic)
IS  - 0003-4819 (Linking)
VI  - 156
IP  - 11
DP  - 2012 Jun 5
TI  - Conflicts of interest ethics: silencing expertise in the development of
      international clinical practice guidelines.
PG  - 809-16, W-283
LID - 10.7326/0003-4819-156-11-201206050-00008 [doi]
AB  - BACKGROUND: It is unclear whether global experts with financial conflicts of
      interest (FCOIs) should be included in, be excluded from, or have a limited role 
      in developing international clinical practice guidelines (CPGs). Optimal
      management of FCOIs to ensure independent, expert CPGs remains ethically
      contested. OBJECTIVE: To manage FCOIs and examine whether an ethics framework
      with discussion recusal by experts with FCOIs affects deliberations and voting on
      a CPG. DESIGN: Development of an ethics framework grounded on transparency and
      proportional management of COIs, including self-recusal, evaluation of the effect
      on COIs and CPG process by quantification of voting on recommendations, and
      qualitative assessment of experts' ethics dialogue. SETTING: International
      consensus meeting to formulate a CPG in gastroenterology. PARTICIPANTS: 34
      experts from 15 countries. MEASUREMENTS: Counting the votes of experts with and
      without declared FCOIs and qualitative assessment of ethics discussions. RESULTS:
      62% of experts reported at least 1 FCOI. Eight out of 21 recommendations
      presented potential FCOIs. Experts with conflicts recused themselves from
      discussing 6 of the 8 recommendations, leaving a majority of nonconflicted
      discussants (median, 22; range, 19 to 26) for the 6 recommendations. Recusals did
      not affect voting outcomes but may have diluted the richness of the discussions. 
      Ethics dialogue revealed accord on transparency but underscored challenges to
      proportional management of COIs beyond basic disclosure. Concerns about bias, COI
      definitions, expertise, and integrity express important international ethics
      questions. LIMITATION: Small participant numbers and application of the framework
      to only 1 meeting of 1 CPG. CONCLUSION: An ethics framework may help to identify 
      and manage COIs and catalyze both ethics dialogue and innovative COI standards
      that seek to balance impartiality and expertise for trusted CPGs. Optimal
      balancing remains contested. Recommendations include frameworks,
      interdisciplinary analysis, and international policy initiatives to better manage
      COIs in the CPG process. PRIMARY FUNDING SOURCE: Canadian Association of
      Gastroenterology; European Association for Gastroenterology and Endoscopy; Asian 
      Pacific Society of Digestive Endoscopy; and Institute of Diabetes, Metabolism,
      and Nutrition of the Canadian Institutes of Health Research.
FAU - Jones, Derek J
AU  - Jones DJ
AD  - Division of Gastroenterology, Montreal General Hospital Site, McGill University
      Health Centre, Montreal, Quebec, Canada.
FAU - Barkun, Alan N
AU  - Barkun AN
FAU - Lu, Yidan
AU  - Lu Y
FAU - Enns, Robert
AU  - Enns R
FAU - Sinclair, Paul
AU  - Sinclair P
FAU - Martel, Myriam
AU  - Martel M
FAU - Gralnek, Ian
AU  - Gralnek I
FAU - Bardou, Marc
AU  - Bardou M
FAU - Kuipers, Ernst J
AU  - Kuipers EJ
FAU - Sung, Joseph
AU  - Sung J
CN  - International Consensus Upper Gastrointestinal Bleeding Conference Group
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Consensus Development Conference
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ann Intern Med
JT  - Annals of internal medicine
JID - 0372351
SB  - IM
MH  - *Conflict of Interest
MH  - Ethics Committees
MH  - Evaluation Studies as Topic
MH  - Financial Support
MH  - Gastroenterology
MH  - Health Policy
MH  - *Practice Guidelines as Topic
MH  - Societies/economics
IR  - Agreus L
FIR - Agreus, Lars
IR  - Armstrong D
FIR - Armstrong, David
IR  - Calvet X
FIR - Calvet, Xavier
IR  - Chiba N
FIR - Chiba, Naoki
IR  - Cipolletta L
FIR - Cipolletta, Livio
IR  - Cohen H
FIR - Cohen, Henry
IR  - Ericsson LG
FIR - Ericsson, Lars-Gunnar
IR  - Hunt R
FIR - Hunt, Richard
IR  - Jensen D
FIR - Jensen, Dennis
IR  - Kaminishi M
FIR - Kaminishi, Michio
IR  - Kanwal F
FIR - Kanwal, Fasiha
IR  - Laine L
FIR - Laine, Loren
IR  - Lanas A
FIR - Lanas, Angel
IR  - Lau J
FIR - Lau, James
IR  - Leontiadis G
FIR - Leontiadis, Grigoris
IR  - Lundell L
FIR - Lundell, Lars
IR  - Malfertheiner P
FIR - Malfertheiner, Peter
IR  - Marshall J
FIR - Marshall, John
IR  - Martin J
FIR - Martin, Janet
IR  - Metz D
FIR - Metz, David
IR  - Moayyedi P
FIR - Moayyedi, Paul
IR  - Quenot JP
FIR - Quenot, Jean-Pierre
IR  - Rauws E
FIR - Rauws, Erik
IR  - Romagnuolo J
FIR - Romagnuolo, Joseph
IR  - Rostom A
FIR - Rostom, Alaa
IR  - Spiegel B
FIR - Spiegel, Brennan
IR  - Tse F
FIR - Tse, Frances
IR  - Van Leerdam M
FIR - Van Leerdam, Monique
IR  - Van Rensburg C
FIR - Van Rensburg, Christo
EDAT- 2012/06/06 06:00
MHDA- 2012/08/14 06:00
CRDT- 2012/06/06 06:00
PHST- 2012/06/06 06:00 [entrez]
PHST- 2012/06/06 06:00 [pubmed]
PHST- 2012/08/14 06:00 [medline]
AID - 156/11/809 [pii]
AID - 10.7326/0003-4819-156-11-201206050-00008 [doi]
PST - ppublish
SO  - Ann Intern Med. 2012 Jun 5;156(11):809-16, W-283. doi:
      10.7326/0003-4819-156-11-201206050-00008.


PMID- 22665474
OWN - NLM
STAT- MEDLINE
DCOM- 20130201
LR  - 20211021
IS  - 1757-790X (Electronic)
IS  - 1757-790X (Linking)
VI  - 2012
DP  - 2012 Feb 21
TI  - Aortic valve replacement in a Jehovah's Witness: a case of multi-disciplinary
      clinical management for bloodless surgery.
LID - 10.1136/bcr.12.2011.5403 [doi]
LID - bcr1220115403 [pii]
AB  - An 81-year-old female Jehovah's Witness (JW) patient with severe aortic stenosis 
      required aortic valve replacement (AVR). However, the patient's religious beliefs
      precluded the use of primary blood components. Since the definitive treatment of 
      AVR required bloodless open heart surgery, careful peri-operative plans were set 
      forth by a multi-disciplinary team involving the cardiothoracic surgeon,
      haematologist and anaesthetist. The patient went on to successfully recover
      postoperatively. This case highlights: 1) The importance of carefully navigating 
      through the most recent clinical and ethical protocol involved in the surgical
      management of JW's. 2) The importance of preparing individually tailored pre,
      intra and postoperative plans that are delivered through a multi-disciplinary
      clinical team to ensure the best and safest possible outcomes.
FAU - Park, John Jungpa
AU  - Park JJ
AD  - University of Edinburgh Medical School, College of Medicine and Veterinary
      Medicine, The University of Edinburgh, Edinburgh, UK. j_park1088@hotmail.com
FAU - Lang, Christopher C
AU  - Lang CC
FAU - Manson, Lynn
AU  - Manson L
FAU - Brackenbury, Edward T
AU  - Brackenbury ET
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20120221
PL  - England
TA  - BMJ Case Rep
JT  - BMJ case reports
JID - 101526291
SB  - IM
MH  - Aged, 80 and over
MH  - Aortic Valve Stenosis/*surgery
MH  - Bloodless Medical and Surgical Procedures/ethics/*methods
MH  - Female
MH  - Heart Valve Prosthesis Implantation/ethics/*methods
MH  - Humans
MH  - *Jehovah's Witnesses
MH  - Patient Care Team
PMC - PMC3291034
EDAT- 2012/06/06 06:00
MHDA- 2013/02/05 06:00
CRDT- 2012/06/06 06:00
PHST- 2012/06/06 06:00 [entrez]
PHST- 2012/06/06 06:00 [pubmed]
PHST- 2013/02/05 06:00 [medline]
AID - bcr.12.2011.5403 [pii]
AID - 10.1136/bcr.12.2011.5403 [doi]
PST - epublish
SO  - BMJ Case Rep. 2012 Feb 21;2012. pii: bcr.12.2011.5403. doi:
      10.1136/bcr.12.2011.5403.


PMID- 22665236
OWN - NLM
STAT- MEDLINE
DCOM- 20121015
LR  - 20211021
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Linking)
VI  - 882
DP  - 2012
TI  - Standard methods for the management of immunogenetic data.
PG  - 197-213
LID - 10.1007/978-1-61779-842-9_12 [doi]
AB  - In this chapter, we outline some basic principles for the consistent management
      of immunogenetic data. These include the preparation of a single master data file
      that can serve as the basis for all subsequent analyses, a focus on the quality
      and homogeneity of the data to be analyzed, the documentation of the coding
      systems used to represent the data, and the application of nomenclature standards
      specific for each immunogenetic system being evaluated. The data management
      principles discussed here are intended to provide a foundation for the data
      analysis methods detailed in Chaps. 13 and 14 . The relationship between the data
      management and analysis methods covered in these three chapters is illustrated in
      Fig. 3.The application of these data management principles is a first step toward
      consistent and reproducible data analyses. While it may take extra time and
      effort to apply them, we feel that it is better to take this approach than to
      assume that low data quality can be compensated for by large sample sizes.In
      addition to their relevance for analytical reproducibility, it is important to
      consider these data management principles from an ethical perspective. The
      reliability of the data collected and generated as part of a research study
      should be as important a component of the ethical review of a research
      application as the security of those data. Finally, in addition to ensuring the
      integrity of the data from collection to publication, the application of these
      data management principles will provide a means to foster research integrity and 
      to improve the potential for collaborative data sharing.
FAU - Gourraud, Pierre-Antoine
AU  - Gourraud PA
AD  - Department of Neurology, University of California, San Francisco, CA, USA.
      pierreantoine.gourraud@ucsf.edu
FAU - Hollenbach, Jill A
AU  - Hollenbach JA
FAU - Barnetche, Thomas
AU  - Barnetche T
FAU - Single, Richard M
AU  - Single RM
FAU - Mack, Steven J
AU  - Mack SJ
LA  - eng
GR  - N01AI40076/AI/NIAID NIH HHS/United States
GR  - U01 AI067068/AI/NIAID NIH HHS/United States
GR  - U19 AI067152/AI/NIAID NIH HHS/United States
GR  - U01AI067068/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Databases, Genetic
MH  - HLA Antigens/*genetics
MH  - Histocompatibility Testing/*methods/standards
MH  - Humans
MH  - Immunogenetics/*methods/*standards
PMC - PMC4209945
MID - NIHMS632758
EDAT- 2012/06/06 06:00
MHDA- 2012/10/16 06:00
CRDT- 2012/06/06 06:00
PHST- 2012/06/06 06:00 [entrez]
PHST- 2012/06/06 06:00 [pubmed]
PHST- 2012/10/16 06:00 [medline]
AID - 10.1007/978-1-61779-842-9_12 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2012;882:197-213. doi: 10.1007/978-1-61779-842-9_12.


PMID- 22665147
OWN - NLM
STAT- MEDLINE
DCOM- 20120809
LR  - 20120605
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Linking)
VI  - 78
IP  - 23
DP  - 2012 Jun 5
TI  - Ethics: end-of-life decision-making in a pediatric patient with SMA type 2: the
      influence of the media.
PG  - e143-5
LID - 10.1212/WNL.0b013e318258f835 [doi]
AB  - OBJECTIVE: Spinal muscular atrophy (SMA) is a group of progressive and fatal
      neurodegenerative disorders that are characterized by destruction of the anterior
      horn cells of the spinal cord. In this case report we outline the medical and
      ethical issues involved in a 7-year-old boy with SMA type 2 who experienced acute
      respiratory failure. METHODS: A review of the literature was conducted focusing
      particularly on the pathology, presentation, and outcomes of SMA and end-of-life 
      decision-making in pediatrics. RESULTS: In a world where 40%-60% of deaths in
      pediatric intensive care units are a result of withdrawal or limitation of
      life-sustaining treatment, end-of-life decision-making has become an integral and
      difficult part of pediatric practice. CONCLUSION: Limitation or withdrawal of
      life-sustaining treatment in a cognitively normal child with SMA poses a
      significant medical and ethical dilemma. This difficult decision is influenced by
      confluence of parental, doctor, social, cultural, moral, religious, legal, and
      economic factors and more recently the media.
FAU - Drake, Madeline
AU  - Drake M
AD  - The Hospital for Sick Children, University of Toronto, Canada.
      madelinejdrake@gmail.com
FAU - Cox, Peter
AU  - Cox P
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
SB  - IM
MH  - Child
MH  - Communications Media/*ethics
MH  - Decision Making/*ethics
MH  - Humans
MH  - Male
MH  - Pediatrics/*ethics
MH  - Spinal Muscular Atrophies of Childhood/economics/*physiopathology/psychology
MH  - Terminal Care/*ethics
EDAT- 2012/06/06 06:00
MHDA- 2012/08/10 06:00
CRDT- 2012/06/06 06:00
PHST- 2012/06/06 06:00 [entrez]
PHST- 2012/06/06 06:00 [pubmed]
PHST- 2012/08/10 06:00 [medline]
AID - 78/23/e143 [pii]
AID - 10.1212/WNL.0b013e318258f835 [doi]
PST - ppublish
SO  - Neurology. 2012 Jun 5;78(23):e143-5. doi: 10.1212/WNL.0b013e318258f835.


PMID- 22665031
OWN - NLM
STAT- MEDLINE
DCOM- 20121016
LR  - 20120605
IS  - 1538-3628 (Electronic)
IS  - 1072-4710 (Linking)
VI  - 166
IP  - 6
DP  - 2012 Jun 1
TI  - Gestational ageism.
PG  - 567-72
LID - 10.1001/archpediatrics.2011.1262 [doi]
AB  - Published guidelines for resuscitation of extremely premature infants emphasize
      the importance of the gestational age of the infant. However, some ethicists and 
      pediatricians have questioned these guidelines, suggesting that this may
      represent a form of discrimination. A policy of nonresuscitation of elderly
      patients older than a certain age would constitute a form of ageism and would
      likely be unacceptable to the broader community. Are resuscitation decisions for 
      premature newborn infants analogous to resuscitation of elderly patients? Are
      current neonatal resuscitation guidelines discriminatory? This article looks at
      the relationship between discrimination based on gestational age and
      chronological age. There are 2 levels of gestational ageism and 2 separate
      strands of argument against gestational age guidelines. I conclude that
      resuscitation decisions for premature infants share many features with those for 
      elderly patients, although there are also some relevant differences. I propose
      the use of gestational age equivalence as an alternative framework for practice.
FAU - Wilkinson, Dominic J C
AU  - Wilkinson DJ
AD  - Robinson Institute, Discipline of Obstetrics and Gynecology, University of
      Adelaide, Australia. dominic.wilkinson@adelaide.edu.au
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Arch Pediatr Adolesc Med
JT  - Archives of pediatrics & adolescent medicine
JID - 9422751
SB  - IM
CIN - Arch Pediatr Adolesc Med. 2012 Jun 1;166(6):580-1. PMID: 22665036
MH  - Age Factors
MH  - *Decision Making/ethics
MH  - *Gestational Age
MH  - Humans
MH  - Infant, Newborn
MH  - *Infant, Premature
MH  - Practice Guidelines as Topic
MH  - *Prejudice
MH  - Resuscitation
MH  - Resuscitation Orders/*ethics
EDAT- 2012/06/06 06:00
MHDA- 2012/10/17 06:00
CRDT- 2012/06/06 06:00
PHST- 2012/06/06 06:00 [entrez]
PHST- 2012/06/06 06:00 [pubmed]
PHST- 2012/10/17 06:00 [medline]
AID - 1171942 [pii]
AID - 10.1001/archpediatrics.2011.1262 [doi]
PST - ppublish
SO  - Arch Pediatr Adolesc Med. 2012 Jun 1;166(6):567-72. doi:
      10.1001/archpediatrics.2011.1262.


PMID- 22664877
OWN - NLM
STAT- MEDLINE
DCOM- 20121011
LR  - 20120605
IS  - 1538-8646 (Electronic)
IS  - 0730-4625 (Linking)
VI  - 31
IP  - 4
DP  - 2012 Jul-Aug
TI  - Donation after cardiac death: ethical dilemmas and implications for advanced
      practice nurses.
PG  - 228-34
LID - 10.1097/DCC.0b013e318256d7dc [doi]
AB  - Donation after cardiac death has always presented ethical concerns among health
      care providers. As advanced practice nurses and critical care nurses, it is our
      responsibility to ensure that health care providers and families are educated
      about the process and that we remain advocates for the potential donors. This
      article reviews the donation after cardiac death process, provides a donation
      after cardiac death hypothetical case report and its outcome, and addresses the
      ethical concerns associated with donation after cardiac death from both
      opponents' and proponents' points of view. It will also discuss the benefits of
      obtaining a palliative care consult and the roles of the advanced practice nurse 
      in the care of the potential donor.
FAU - Everidge, Caryn S
AU  - Everidge CS
AD  - Edward Neurosciences Institute, Edward Hospital, Naperville, IL 60540, USA.
      caryn1277@aol.com
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Dimens Crit Care Nurs
JT  - Dimensions of critical care nursing : DCCN
JID - 8211489
MH  - Advanced Practice Nursing/ethics
MH  - *Death
MH  - Decision Making/ethics
MH  - Family/psychology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Terminal Care/*ethics
MH  - Tissue Donors/*ethics
MH  - Tissue and Organ Procurement/*ethics/legislation & jurisprudence
EDAT- 2012/06/06 06:00
MHDA- 2012/10/12 06:00
CRDT- 2012/06/06 06:00
PHST- 2012/06/06 06:00 [entrez]
PHST- 2012/06/06 06:00 [pubmed]
PHST- 2012/10/12 06:00 [medline]
AID - 10.1097/DCC.0b013e318256d7dc [doi]
AID - 00003465-201207000-00003 [pii]
PST - ppublish
SO  - Dimens Crit Care Nurs. 2012 Jul-Aug;31(4):228-34. doi:
      10.1097/DCC.0b013e318256d7dc.


PMID- 22664628
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1920-1214 (Electronic)
IS  - 1911-6470 (Linking)
VI  - 6
IP  - 3
DP  - 2012 Jun
TI  - Ethics in publishing.
PG  - 181-2
LID - 10.5489/cuaj.12126 [doi]
FAU - Fitzpatrick, John M
AU  - Fitzpatrick JM
AD  - BJU International, London, United Kingdom.
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Can Urol Assoc J
JT  - Canadian Urological Association journal = Journal de l'Association des urologues 
      du Canada
JID - 101312644
PMC - PMC3367012
EDAT- 2012/06/06 06:00
MHDA- 2012/06/06 06:01
CRDT- 2012/06/06 06:00
PHST- 2012/06/06 06:00 [entrez]
PHST- 2012/06/06 06:00 [pubmed]
PHST- 2012/06/06 06:01 [medline]
AID - cuaj.12126 [pii]
AID - 10.5489/cuaj.12126 [doi]
PST - ppublish
SO  - Can Urol Assoc J. 2012 Jun;6(3):181-2. doi: 10.5489/cuaj.12126.


PMID- 22664524
OWN - NLM
STAT- MEDLINE
DCOM- 20121025
LR  - 20191112
IS  - 1809-4546 (Electronic)
IS  - 0100-6991 (Linking)
VI  - 39
IP  - 2
DP  - 2012 Apr
TI  - [Tolerance, courage and compassion: cardinal virtues of the surgeon].
PG  - 155-8
LID - S0100-69912012000200013 [pii]
AB  - Interactions among human beings are very complex. Using only an ethical code as
      reference to deal with moral conflicts is hardly ever enough. Responsibility
      ethics demand such a profound reflection as well as a discussion about human
      essence and its role in society. The responsibility of a surgeon is inherent in a
      profession based since its origin, not only on altruism and humanity, but also on
      compassion, courage and tolerance. The studies and the comprehension of these
      qualities as well as the transmission of these values to the students and to the 
      surgery residents are essential for human education of these individuals. This
      essay offers to show that these essential virtues are strongly connected to the
      work the surgeon develops whereas his/her responsibility starts before the
      surgery - when one intends to act.
FAU - Soares Junior, Cleber
AU  - Soares Junior C
AD  - Hospital Therezinha de Jesus, Faculdade de Ciencias Medicas de Juiz de Fora,
      Minas Gerais, Brazil. cleberdoc@ig.com.br
FAU - Gomes, Carlos Augusto
AU  - Gomes CA
FAU - Peixoto, Rodrigo de Oliveira
AU  - Peixoto Rde O
FAU - Soares, Fernanda Pardo de Toledo Piza
AU  - Soares FP
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Tolerancia, coragem e compaixao: virtudes cardinais do cirurgiao.
PL  - Brazil
TA  - Rev Col Bras Cir
JT  - Revista do Colegio Brasileiro de Cirurgioes
JID - 7809515
SB  - IM
MH  - Education, Medical
MH  - *Empathy
MH  - *General Surgery/education
MH  - Humans
MH  - *Physician-Patient Relations
MH  - *Virtues
EDAT- 2012/06/06 06:00
MHDA- 2012/10/26 06:00
CRDT- 2012/06/06 06:00
PHST- 2012/06/06 06:00 [entrez]
PHST- 2012/06/06 06:00 [pubmed]
PHST- 2012/10/26 06:00 [medline]
AID - S0100-69912012000200013 [pii]
AID - 10.1590/s0100-69912012000200013 [doi]
PST - ppublish
SO  - Rev Col Bras Cir. 2012 Apr;39(2):155-8. doi: 10.1590/s0100-69912012000200013.


PMID- 22664452
OWN - NLM
STAT- MEDLINE
DCOM- 20120928
LR  - 20181201
IS  - 1998-3646 (Electronic)
IS  - 0255-0857 (Linking)
VI  - 30
IP  - 2
DP  - 2012 Apr-Jun
TI  - Ethical issues on carrying out research on archived samples.
PG  - 249-50; author reply 250
LID - 10.4103/0255-0857.96719 [doi]
FAU - Wattal, C
AU  - Wattal C
FAU - Goel, N
AU  - Goel N
LA  - eng
PT  - Letter
PT  - Comment
PL  - United States
TA  - Indian J Med Microbiol
JT  - Indian journal of medical microbiology
JID - 8700903
SB  - IM
CON - Indian J Med Microbiol. 2011 Oct-Dec;29(4):327-30. PMID: 22120789
MH  - Biomedical Research/*ethics/*methods
MH  - Clinical Laboratory Techniques/*ethics/*methods
MH  - Communicable Diseases/*diagnosis
MH  - Humans
EDAT- 2012/06/06 06:00
MHDA- 2012/09/29 06:00
CRDT- 2012/06/06 06:00
PHST- 2012/06/06 06:00 [entrez]
PHST- 2012/06/06 06:00 [pubmed]
PHST- 2012/09/29 06:00 [medline]
AID - IndianJMedMicrobiol_2012_30_2_249_96719 [pii]
AID - 10.4103/0255-0857.96719 [doi]
PST - ppublish
SO  - Indian J Med Microbiol. 2012 Apr-Jun;30(2):249-50; author reply 250. doi:
      10.4103/0255-0857.96719.


PMID- 22663973
OWN - NLM
STAT- MEDLINE
DCOM- 20120710
LR  - 20211021
IS  - 0020-1324 (Print)
IS  - 0020-1324 (Linking)
VI  - 57
IP  - 6
DP  - 2012 Jun
TI  - Integration of palliative care in chronic critical illness management.
PG  - 1004-12; discussion 1012-3
LID - 10.4187/respcare.01624 [doi]
AB  - Palliative care is an essential component of comprehensive care for all patients 
      with chronic critical illness, including those receiving restorative or
      life-sustaining therapies. Core elements include alleviation of symptom distress,
      communication about care goals, alignment of treatment with the patient's values 
      and preferences, transitional planning, and family support. Here we address
      strategies for assessment and management of symptoms, including pain, dyspnea,
      and depression, and for assisting patients to communicate while endotracheally
      intubated. We also discuss approaches to optimize communication among clinicians,
      patients, and families about care goals. Challenges for supporting families and
      planning for transitions between care settings are identified, while the value of
      interdisciplinary input is emphasized. We review "consultative" and "integrative"
      models for integrating palliative care and restorative critical care. Finally, we
      highlight key ethical issues that arise in the care of chronically critically ill
      patients and their families.
CI  - 2012 Daedalus Enterprises
FAU - Nelson, Judith E
AU  - Nelson JE
AD  - Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine,
      Mount Sinai School of Medicine, New York, New York 10029, USA.
      judith.nelson@mssm.edu
FAU - Hope, Aluko A
AU  - Hope AA
LA  - eng
GR  - K07 AG034234/AG/NIA NIH HHS/United States
GR  - R01 NR012413/NR/NINR NIH HHS/United States
GR  - K07-AG034234/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United States
TA  - Respir Care
JT  - Respiratory care
JID - 7510357
SB  - IM
MH  - Chronic Disease
MH  - Communication
MH  - Critical Care/ethics/*organization & administration
MH  - Critical Illness/*therapy
MH  - Ethics, Medical
MH  - Humans
MH  - Intensive Care Units
MH  - Palliative Care/ethics/*organization & administration
MH  - Physician-Patient Relations
MH  - *Respiration, Artificial/ethics
PMC - PMC5065723
MID - NIHMS390510
EDAT- 2012/06/06 06:00
MHDA- 2012/07/11 06:00
CRDT- 2012/06/06 06:00
PHST- 2012/06/06 06:00 [entrez]
PHST- 2012/06/06 06:00 [pubmed]
PHST- 2012/07/11 06:00 [medline]
AID - 10.4187/respcare.01624 [doi]
PST - ppublish
SO  - Respir Care. 2012 Jun;57(6):1004-12; discussion 1012-3. doi:
      10.4187/respcare.01624.


PMID- 22663960
OWN - NLM
STAT- MEDLINE
DCOM- 20121022
LR  - 20220321
IS  - 2212-3911 (Electronic)
IS  - 1574-8863 (Linking)
VI  - 7
IP  - 1
DP  - 2012 Feb
TI  - Impulsive and compulsive behaviors during dopamine replacement treatment in
      Parkinson's Disease and other disorders.
PG  - 63-75
AB  - Impulsive and compulsive behaviors, including pathologic gambling,
      hypersexuality, compulsive shopping, compulsive eating, excessive engagement in
      hobbies, punding, and Dopamine Dysregulation Syndrome (DDS), are increasingly
      reported serious side-effects of dopaminergic medication, used in the treatment
      of Parkinson's Disease (PD) and other disorders. Dopamine Agonists (DA) are
      strongly related with Impulse Control Disorders (ICDs), while L-dopa is
      associated with DDS. The present paper focuses on ICDs. The estimated prevalence 
      of ICDs in PD patients treated with DA is as high as 14%. ICDs pathophysiology is
      complex, due to multiple contributing factors. Dopamine neurotransmission along
      the meso-cortico-limbic pathway is a modulator of risk behavior and can be
      altered in PD and in the course of dopaminergic treatment. Psychiatric
      complications, associated with treatment of PD are still underdiagnosed, although
      their consequences can be serious, even catastrophic. Physicians treating PD with
      DA should warn the patients and their relatives of the risk of inducing ICDs.
      Psychiatrists should be trained to recognize these side effects, that can mimic
      primary psychiatric conditions. The management of ICDs includes discontinuation
      of DA or switching from DA to other drugs for the treatment of PD. Cognitive
      behavior therapy, serotonin selective reuptake inhibitors, nalmefene, zonisamide,
      low dose of anti-dopaminergic drugs, as quetiapine or clozapine, can be
      effective. Psychological, spiritual, and ethical support (familial or individual)
      can help.
FAU - Raja, Michele
AU  - Raja M
AD  - Centro Studi e Ricerche Gaetano Perusini, Rome, Italy. michele.raja@libero.it
FAU - Bentivoglio, Anna Rita
AU  - Bentivoglio AR
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Drug Saf
JT  - Current drug safety
JID - 101270895
RN  - 0 (Dopamine Agonists)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Cognitive Behavioral Therapy/methods
MH  - Compulsive Behavior/*chemically induced/epidemiology/therapy
MH  - Dopamine/metabolism
MH  - Dopamine Agonists/*adverse effects/therapeutic use
MH  - Humans
MH  - Impulsive Behavior/*chemically induced/epidemiology/therapy
MH  - Parkinson Disease/drug therapy
MH  - Patient Education as Topic/methods
MH  - Prevalence
MH  - Syndrome
EDAT- 2012/06/06 06:00
MHDA- 2012/10/23 06:00
CRDT- 2012/06/06 06:00
PHST- 2011/12/21 00:00 [received]
PHST- 2012/03/14 00:00 [revised]
PHST- 2012/03/15 00:00 [accepted]
PHST- 2012/06/06 06:00 [entrez]
PHST- 2012/06/06 06:00 [pubmed]
PHST- 2012/10/23 06:00 [medline]
AID - CDS-7-1-63 [pii]
AID - 10.2174/157488612800492726 [doi]
PST - ppublish
SO  - Curr Drug Saf. 2012 Feb;7(1):63-75. doi: 10.2174/157488612800492726.


PMID- 22663308
OWN - NLM
STAT- MEDLINE
DCOM- 20121010
LR  - 20120605
IS  - 1364-6893 (Electronic)
IS  - 0144-3615 (Linking)
VI  - 32
IP  - 5
DP  - 2012 Jul
TI  - Is it time to actively look for vasa praevia?
PG  - 413-8
LID - 10.3109/01443615.2012.673038 [doi]
AB  - Vasa praevia can cause acute severe fetal haemorrhage prior to or during rupture 
      of the membranes, contributing to perinatal morbidity and mortality. There are no
      large prospective studies relating to vasa praevia and there is no place for a
      randomised controlled trial as it would be ethically unjustifiable given the poor
      prognosis. There are no national guidelines for the management of vasa praevia.
      Identification of vasa praevia by the 3rd trimester of pregnancy warrants the
      offer of delivery by planned caesarean section to avoid the complications. This
      is essentially intuitive and logical rather than based on any randomised trials. 
      A universal screening programme for vasa praevia is not currently supported by a 
      robust evidence base; however, the role of prenatal diagnosis requires an
      informed debate, as high quality data may not be forthcoming, given the low
      evidence of the condition. Increasing awareness and understanding of the clinical
      situations can accumulate information, which identify and treat this tragic
      complication of childbirth.
FAU - Nishtar, A
AU  - Nishtar A
AD  - Department of Obstetrics & Gynaecology, Northampton General Hospital,
      Northampton, UK. anishtar14@yahoo.co.uk
FAU - Wood, P L
AU  - Wood PL
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Obstet Gynaecol
JT  - Journal of obstetrics and gynaecology : the journal of the Institute of
      Obstetrics and Gynaecology
JID - 8309140
SB  - IM
MH  - Cesarean Section
MH  - Female
MH  - Fetal Diseases/etiology
MH  - Gestational Age
MH  - Hemorrhage/etiology
MH  - Humans
MH  - Mass Screening
MH  - Perinatal Mortality
MH  - Pregnancy
MH  - *Prenatal Diagnosis
MH  - Vasa Previa/*diagnosis/therapy
EDAT- 2012/06/06 06:00
MHDA- 2012/10/12 06:00
CRDT- 2012/06/06 06:00
PHST- 2012/06/06 06:00 [entrez]
PHST- 2012/06/06 06:00 [pubmed]
PHST- 2012/10/12 06:00 [medline]
AID - 10.3109/01443615.2012.673038 [doi]
PST - ppublish
SO  - J Obstet Gynaecol. 2012 Jul;32(5):413-8. doi: 10.3109/01443615.2012.673038.


PMID- 22662582
OWN - NLM
STAT- MEDLINE
DCOM- 20120719
LR  - 20120605
IS  - 1354-5760 (Print)
IS  - 1354-5760 (Linking)
VI  - 19
IP  - 1
DP  - 2012 Apr
TI  - Ethics of everyday decision making.
PG  - 32-6
AB  - Evidence suggests that checklists can prevent episodes of patient harm and they
      are increasingly being used in patient care to ensure that procedures are being
      carried out. However, checklists cannot do so alone and in some situations the
      checklist might indicate that an intervention has been undertaken when it has
      not. Healthcare providers, particularly nurses, must consider not only the
      increase in the use of checklists, but also the way in which they present a
      context for ethical decision making. This article examines the ethical dimensions
      of using checklists, played out in the context of a scenario, and suggests that
      failure to take ethics into account when considering checklists might perpetuate 
      rather than prevent unsafe practices or errors. The article is set in a US
      context, but the issues are relevant to healthcare settings in any part of the
      world.
FAU - Kearney, Gina
AU  - Kearney G
AD  - Communities Hospital, Oceanside, NY, USA. gkearney@snch.org
FAU - Penque, Sue
AU  - Penque S
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Manag (Harrow)
JT  - Nursing management (Harrow, London, England : 1994)
JID - 9433248
MH  - *Checklist
MH  - Decision Making/*ethics
MH  - Documentation/*methods
MH  - Ethics, Nursing
MH  - Humans
MH  - *Nursing Records
MH  - *Patient Safety
MH  - United States
EDAT- 2012/06/06 06:00
MHDA- 2012/07/20 06:00
CRDT- 2012/06/06 06:00
PHST- 2012/06/06 06:00 [entrez]
PHST- 2012/06/06 06:00 [pubmed]
PHST- 2012/07/20 06:00 [medline]
AID - 10.7748/nm2012.04.19.1.32.c9015 [doi]
PST - ppublish
SO  - Nurs Manag (Harrow). 2012 Apr;19(1):32-6. doi: 10.7748/nm2012.04.19.1.32.c9015.


PMID- 22662570
OWN - NLM
STAT- MEDLINE
DCOM- 20120626
LR  - 20181201
IS  - 0031-9376 (Print)
IS  - 0031-9376 (Linking)
VI  - 55
IP  - 2
DP  - 2012 Apr
TI  - Walter C. Randall Lecture on Biomedical Ethics: Colleagues as a defense against
      bad science.
PG  - 52-6
FAU - Koocher, Gerald P
AU  - Koocher GP
AD  - Simmons College, Boston, MA, USA.
LA  - eng
PT  - Lecture
PL  - United States
TA  - Physiologist
JT  - The Physiologist
JID - 0401143
SB  - IM
MH  - *Bioethical Issues/standards
MH  - Biomedical Research/*ethics/standards
MH  - Conflict of Interest
MH  - *Cooperative Behavior
MH  - *Ethics, Research
MH  - Humans
MH  - *Interpersonal Relations
MH  - Motivation
MH  - Research Support as Topic/ethics
MH  - Scientific Misconduct/*ethics
MH  - Whistleblowing/ethics
EDAT- 2012/06/06 06:00
MHDA- 2012/06/27 06:00
CRDT- 2012/06/06 06:00
PHST- 2012/06/06 06:00 [entrez]
PHST- 2012/06/06 06:00 [pubmed]
PHST- 2012/06/27 06:00 [medline]
PST - ppublish
SO  - Physiologist. 2012 Apr;55(2):52-6.


PMID- 22662426
OWN - NLM
STAT- MEDLINE
DCOM- 20120803
LR  - 20120815
IS  - 1320-3185 (Print)
IS  - 1320-3185 (Linking)
VI  - 19
IP  - 8
DP  - 2012 Mar
TI  - University nurse education--ethics or ideology?
PG  - 17
FAU - Johnstone, Megan-Jane
AU  - Johnstone MJ
AD  - School of Nursing, Deakin University, Victoria.
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Aust Nurs J
JT  - Australian nursing journal (July 1993)
JID - 9317904
CIN - Aust Nurs J. 2012 Apr;19(9):3. PMID: 22616291
MH  - Australia
MH  - Education, Nursing, Baccalaureate/*ethics/*organization & administration
MH  - Female
MH  - Humans
MH  - *Politics
MH  - Prejudice
MH  - *Public Policy
MH  - Women's Rights/*ethics
EDAT- 2012/06/06 06:00
MHDA- 2012/08/04 06:00
CRDT- 2012/06/06 06:00
PHST- 2012/06/06 06:00 [entrez]
PHST- 2012/06/06 06:00 [pubmed]
PHST- 2012/08/04 06:00 [medline]
PST - ppublish
SO  - Aust Nurs J. 2012 Mar;19(8):17.


PMID- 22662382
OWN - NLM
STAT- MEDLINE
DCOM- 20120814
LR  - 20120605
IS  - 0026-2102 (Print)
IS  - 0026-2102 (Linking)
VI  - 94
IP  - 3
DP  - 2012 Mar
TI  - Keeping a former owner's name on the practice: is it ethical?
PG  - 22
FAU - Maihofer, Michael
AU  - Maihofer M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Mich Dent Assoc
JT  - The Journal of the Michigan Dental Association
JID - 7505621
MH  - Dentists/*ethics
MH  - *Ethics, Dental
MH  - Humans
MH  - Names
MH  - Ownership/*ethics
MH  - Practice Valuation and Purchase/*ethics
EDAT- 2012/06/06 06:00
MHDA- 2012/08/15 06:00
CRDT- 2012/06/06 06:00
PHST- 2012/06/06 06:00 [entrez]
PHST- 2012/06/06 06:00 [pubmed]
PHST- 2012/08/15 06:00 [medline]
PST - ppublish
SO  - J Mich Dent Assoc. 2012 Mar;94(3):22.


PMID- 22662374
OWN - NLM
STAT- MEDLINE
DCOM- 20120627
LR  - 20131106
IS  - 1351-5578 (Print)
IS  - 1351-5578 (Linking)
VI  - 19
IP  - 3
DP  - 2012
TI  - The use of visual methodology in nursing.
PG  - 20-5
AB  - AIM: To explore the use of visual methodology in nursing. BACKGROUND: Interest in
      the use of visual methodologies is increasing and its use can be adopted in
      healthcare research. DATA SOURCES: Commentary on a study that used drawings to
      explore stress-busting behaviours in nursing students. REVIEW METHODS: Drawing
      from the literature and practical experience, the paper explores the traditions
      of visual research and aspects such as terminology, analysis, ethical issues, the
      advantages and disadvantages of the methodology, and the implications of using
      visual methodology. DISCUSSION: Visual methodology revealed information that
      perhaps would not be elicited by interviews or questionnaires. Dialogue should
      take place, along with images, to ensure correct interpretation. CONCLUSION:
      Digital technology enables the use of visual methodology, which is new in health 
      care and can offer many opportunities to researchers. IMPLICATIONS FOR
      RESEARCH/PRACTICE: Visual research methodologies have the potential to expand in 
      nursing research because of their range of data collection and analytical
      frameworks and because of the possibility of working with the participant.
FAU - Woodhouse, Jan
AU  - Woodhouse J
AD  - Faculty of Health and Social Care, University of Chester, Chester, UK.
      j.woodhouse@chester.ac.uk
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurse Res
JT  - Nurse researcher
JID - 9435953
MH  - *Nursing
MH  - Terminology as Topic
EDAT- 2012/06/06 06:00
MHDA- 2012/06/28 06:00
CRDT- 2012/06/06 06:00
PHST- 2012/06/06 06:00 [entrez]
PHST- 2012/06/06 06:00 [pubmed]
PHST- 2012/06/28 06:00 [medline]
AID - 10.7748/nr2012.04.19.3.20.c9055 [doi]
PST - ppublish
SO  - Nurse Res. 2012;19(3):20-5. doi: 10.7748/nr2012.04.19.3.20.c9055.


PMID- 22661882
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1058-9813 (Print)
IS  - 1058-9813 (Linking)
VI  - 33
IP  - 2
DP  - 2012 May 1
TI  - The FDA Review Process for Cardiac Medical Devices in Children: A Review for the 
      Clinician.
PG  - 105-109
AB  - Pediatric medical devices play a vital role in the treatment of children with
      cardiovascular disease. Most cardiac medical devices used in children today are
      used off-label where the risk-benefit of devices has not been well characterized.
      Pediatric medical devices face a variety of challenges to FDA approval related in
      large part to the small target population, heterogeneity of the patient
      population and ethical considerations of device testing in children. While
      relatively few cardiac devices have received FDA approval in children, the number
      of devices navigating the approval process successfully is growing. Most
      pediatric device approvals are being granted through the humanitarian device
      exemption (HDE) pathway, which is designed for rare diseases making it suitable
      for devices treating congenital heart disease. This review summarizes the FDA
      review process for pediatric medical devices as it continues to evolve in
      response to the unique challenges of understanding device performance in the
      pediatric population.
FAU - Almond, Christopher S
AU  - Almond CS
AD  - Department of Cardiology, Children's Hospital Boston; Department of Pediatrics,
      Harvard Medical School, Boston, MA.
LA  - eng
GR  - L40 RR020587-02/RR/NCRR NIH HHS/United States
GR  - T32 HL007572/HL/NHLBI NIH HHS/United States
PT  - Journal Article
DEP - 20120327
PL  - Netherlands
TA  - Prog Pediatr Cardiol
JT  - Progress in pediatric cardiology
JID - 9209539
PMC - PMC3363973
MID - NIHMS366895
EDAT- 2012/06/05 06:00
MHDA- 2012/06/05 06:01
CRDT- 2012/06/05 06:00
PHST- 2012/06/05 06:00 [entrez]
PHST- 2012/06/05 06:00 [pubmed]
PHST- 2012/06/05 06:01 [medline]
AID - 10.1016/j.ppedcard.2012.02.002 [doi]
PST - ppublish
SO  - Prog Pediatr Cardiol. 2012 May 1;33(2):105-109. doi:
      10.1016/j.ppedcard.2012.02.002. Epub 2012 Mar 27.


PMID- 22661876
OWN - NLM
STAT- MEDLINE
DCOM- 20120919
LR  - 20211021
IS  - 1598-6357 (Electronic)
IS  - 1011-8934 (Linking)
VI  - 27 Suppl
DP  - 2012 May
TI  - Biomedical ethics policy in Korea: characteristics and historical development.
PG  - S76-81
LID - 10.3346/jkms.2012.27.S.S76 [doi]
AB  - Ethical consideration is an inseparable part of policy-making in modern society. 
      Biomedical ethics is an interdisciplinary study of ethical issues that result
      from advances in medical practices and research. Because these issues often arise
      at the bedside, society must provide solutions or judgments that are effective
      and applicable. Thus, the development and progress of biomedical ethics has been 
      made possible via the cooperation of experts from diverse backgrounds. The
      biomedical ethics discourse should not be seen as a conflict between values but
      as a collective activity for problem-solving. To support this perspective on
      ethics discourse, a historical perspective on biomedical ethics in Korea was
      given emphasis on the participants and their perspectives. Major cases and the
      changes resulting therefrom were discussed with the agenda proposed. The Korean
      situation with respect to ethics development shows the interactions between
      groups participating in policy development and its collaborative nature.
FAU - Hahm, Ki-Hyun
AU  - Hahm KH
AD  - Department of Medical Humanities & Social Medicine, Ajou University School of
      Medicine, Suwon, Korea.
FAU - Lee, Ilhak
AU  - Lee I
LA  - eng
PT  - Historical Article
PT  - Journal Article
DEP - 20120518
PL  - Korea (South)
TA  - J Korean Med Sci
JT  - Journal of Korean medical science
JID - 8703518
SB  - IM
MH  - *Bioethics/history
MH  - *Ethics, Medical/history
MH  - Health Policy
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Republic of Korea
PMC - PMC3360179
OTO - NOTNLM
OT  - Biomedical Ethics
OT  - Korea
OT  - Medical Ethics
OT  - Policy
EDAT- 2012/06/05 06:00
MHDA- 2012/09/20 06:00
CRDT- 2012/06/05 06:00
PHST- 2011/06/16 00:00 [received]
PHST- 2012/01/02 00:00 [accepted]
PHST- 2012/06/05 06:00 [entrez]
PHST- 2012/06/05 06:00 [pubmed]
PHST- 2012/09/20 06:00 [medline]
AID - 10.3346/jkms.2012.27.S.S76 [doi]
PST - ppublish
SO  - J Korean Med Sci. 2012 May;27 Suppl:S76-81. doi: 10.3346/jkms.2012.27.S.S76. Epub
      2012 May 18.


PMID- 22661457
OWN - NLM
STAT- MEDLINE
DCOM- 20130128
LR  - 20120723
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 8
DP  - 2012 Aug
TI  - Ethics, organ donation and tax: a reply to Quigley and Taylor.
PG  - 463-4
LID - 10.1136/medethics-2012-100580 [doi]
AB  - A national opt-out system of post-mortem donation of scarce organs is preferable 
      to an opt-in system. Unfortunately, the former system is not always feasible, and
      so in a recent JME article we canvassed the possibility of offering people a tax 
      break for opting-in as a way of increasing the number of organs available for
      donation under an opt-in regime. Muireann Quigley and James Stacey Taylor
      criticize our proposal. Roughly, Quigley argues that our proposal is costly and, 
      hence, is unlikely to be implemented, while Taylor contests our response to a
      Titmuss-style objection to our scheme. In response to Quigley, we note that our
      proposal's main attraction lies in gains not reflected in the figures presented
      by Quigley and that the mere fact that it is costly does not imply that it is
      unfeasible. In response to Taylor, we offer some textual evidence in support of
      our interpretation of Taylor and responds to his favoured interpretation of the
      Titmuss-style objection that many people seem to want to donate to charities even
      if they can deduct their donations from their income tax. Finally, we show why
      our views do not commit us to endorsing a free organ-market.
FAU - Lippert-Rasmussen, Kasper
AU  - Lippert-Rasmussen K
FAU - Petersen, Thomas Sobirk
AU  - Petersen TS
LA  - eng
PT  - Journal Article
DEP - 20120601
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Cadaver
MH  - Denmark
MH  - Humans
MH  - Presumed Consent/*ethics/legislation & jurisprudence
MH  - *Tax Exemption
MH  - Tissue Donors/ethics
MH  - Tissue and Organ Procurement/*ethics/legislation & jurisprudence
EDAT- 2012/06/05 06:00
MHDA- 2013/01/29 06:00
CRDT- 2012/06/05 06:00
PHST- 2012/06/05 06:00 [entrez]
PHST- 2012/06/05 06:00 [pubmed]
PHST- 2013/01/29 06:00 [medline]
AID - medethics-2012-100580 [pii]
AID - 10.1136/medethics-2012-100580 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Aug;38(8):463-4. doi: 10.1136/medethics-2012-100580. Epub 2012
      Jun 1.


PMID- 22660988
OWN - NLM
STAT- MEDLINE
DCOM- 20131112
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 18
IP  - 3
DP  - 2012 Sep
TI  - Ethical decision making in the conduct of research: role of individual,
      contextual and organizational factors. Commentary on "Science, human nature, and 
      a new paradigm for ethics education".
PG  - 551-5
LID - 10.1007/s11948-012-9371-x [doi]
AB  - Despite the importance of scientific integrity to the well-being of society,
      recent findings suggest that training and mentoring in the responsible conduct of
      research are not very reliable or effective inhibitors of research misbehavior.
      Understanding how and why individual scientists decide to behave in ways that
      conform to or violate norms and standards of research is essential to the
      development of more effective training programs and the creation of more
      supportive environments. Scholars in business management, psychology, and other
      disciplines have identified many important factors that affect ethical behavior, 
      including individual, contextual, and organizational factors. Surprisingly little
      research has been conducted to examine the role of these factors in either the
      development of ethical decision-making skills, or their applicability to ethical 
      issues commonly encountered in research and other scholarly and professional
      activities. Interdisciplinary approaches combined with research and discipline
      relevant paradigms should greatly enhance understanding of the individual
      contextual and organizational factors involved in ethical and unethical research 
      conduct. Such studies will inform and facilitate the development of more
      effective ethics education programs in the sciences and engineering professions.
FAU - Langlais, Philip J
AU  - Langlais PJ
AD  - Department of Psychology, Old Dominion University, 130C Mills Godwin Bldg.,
      Norfolk, VA 23520-0267, USA. planglai@odu.edu
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20120603
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
CON - Sci Eng Ethics. 2012 Sep;18(3):543-9. PMID: 22711449
MH  - *Human Characteristics
MH  - Humans
MH  - *Morals
MH  - Neurosciences/*ethics
MH  - Science/*ethics
MH  - *Social Behavior
MH  - Teaching/*ethics
EDAT- 2012/06/05 06:00
MHDA- 2013/11/13 06:00
CRDT- 2012/06/05 06:00
PHST- 2012/01/12 00:00 [received]
PHST- 2012/05/09 00:00 [accepted]
PHST- 2012/06/05 06:00 [entrez]
PHST- 2012/06/05 06:00 [pubmed]
PHST- 2013/11/13 06:00 [medline]
AID - 10.1007/s11948-012-9371-x [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2012 Sep;18(3):551-5. doi: 10.1007/s11948-012-9371-x. Epub 2012
      Jun 3.


PMID- 22659695
OWN - NLM
STAT- MEDLINE
DCOM- 20120802
LR  - 20151119
IS  - 1930-7837 (Electronic)
IS  - 0022-0337 (Linking)
VI  - 76
IP  - 6
DP  - 2012 Jun
TI  - The ethics of live patient use in dental hygiene clinical licensure examinations:
      a national survey.
PG  - 667-81
AB  - A national survey of dental hygienists was conducted to explore ethical issues
      arising from the use of live patients for dental hygiene clinical licensure
      examinations. Data were collected regarding respondents' demographics, additional
      costs they incurred associated with their examination beyond the examination
      fees, delays in patients' treatment resulting from the examination, unethical
      candidate and/or patient behaviors they experienced, and provisions they made for
      patients' follow-up care related to the examination. Five hundred surveys were
      mailed to dental hygienists from two states in each of the five licensure
      examination regions. The response rate was 40.6 percent (n=203). Descriptive
      statistics were used to analyze the data. The results showed that the majority of
      the respondents spent additional money on examination-related expenses (69.2
      percent). Sixty-one percent of the respondents reported paying their patients;
      however, only 50.5 percent felt such a practice was acceptable. More than half
      (53.1 percent) reported believing it was appropriate to delay treatment in order 
      to have a patient participate in the examination, although only 16.4 percent
      reported actually delaying treatment. Informed consent was said to be obtained by
      94.9 percent of the respondents. The majority (86.6 percent) said they referred
      patients for follow-up dental hygiene care. When asked if they felt the
      examination was an accurate assessment of their clinical skills, 78.7 percent of 
      the respondents agreed that it was.
FAU - Lantzy, Marlaina J
AU  - Lantzy MJ
AD  - Dental Hygiene Program, Department of Dental Education, Indiana University-Purdue
      University Fort Wayne, Fort Wayne, IN 46805, USA. lantzym@ipfw.edu
FAU - Muzzin, Kathleen B
AU  - Muzzin KB
FAU - DeWald, Janice P
AU  - DeWald JP
FAU - Solomon, Eric S
AU  - Solomon ES
FAU - Campbell, Patricia R
AU  - Campbell PR
FAU - Mallonee, Lisa
AU  - Mallonee L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Dent Educ
JT  - Journal of dental education
JID - 8000150
SB  - IM
MH  - Costs and Cost Analysis
MH  - Dental Hygienists/economics/*education/*ethics
MH  - *Ethics, Clinical
MH  - Humans
MH  - Informed Consent
MH  - Licensure/*ethics
MH  - *Patients
MH  - Remuneration
MH  - Surveys and Questionnaires
MH  - United States
EDAT- 2012/06/05 06:00
MHDA- 2012/08/03 06:00
CRDT- 2012/06/05 06:00
PHST- 2012/06/05 06:00 [entrez]
PHST- 2012/06/05 06:00 [pubmed]
PHST- 2012/08/03 06:00 [medline]
AID - 76/6/667 [pii]
PST - ppublish
SO  - J Dent Educ. 2012 Jun;76(6):667-81.


PMID- 22658624
OWN - NLM
STAT- MEDLINE
DCOM- 20121026
LR  - 20220409
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 75
IP  - 5
DP  - 2012 Sep
TI  - On ethical locations: the good death in Thailand, where ethics sit in places.
PG  - 836-44
LID - 10.1016/j.socscimed.2012.03.045 [doi]
AB  - In this article, I use ethnographic data on end-of-life care in Northern Thailand
      to address the relationship between ethics and place. My analysis is based on
      fieldwork conducted in 2007-2008, consisting of twenty in-depth oral
      life-histories of dying patients; ninety-five interviews with patients, family
      members and caretakers; fifty-four interviews with providers, administrators,
      civil society leaders and other key informants; as well as
      participant-observation of care of patients at the deathbed. In Northern
      Thailand, many feel that it is ethical to withdraw life support in the home, but 
      unethical to withdraw it in the hospital. This is because the place of death is
      partly responsible for the quality of rebirth. Hospitals, on one hand, are
      powerful for saving lives; but as places to die, they are amoral, dangerous,
      devoid of ceremonial history and haunted by spirits. Homes, on the other hand,
      are optimal for dying because they are imbued with moral power from a history of 
      beneficial ceremony and family living. Hospitalized patients at the edge of death
      are often rushed home by ambulance to withdraw life support in the more ethical
      place. I argue that the two places can be considered different ethical locations,
      because each is inhabited by a unique ethical framework governing withdrawal of
      life support. This concept has implications for the contemporary globalization of
      bioethics and for understanding practices that arise around ethically charged
      decisions.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Stonington, Scott D
AU  - Stonington SD
AD  - Department of Global Health and Social Medicine, Harvard Medical School, United
      States. scott.stonington@stanfordalumni.org
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120502
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Anthropology, Cultural
MH  - *Attitude to Death
MH  - Bioethical Issues
MH  - Home Care Services/*ethics
MH  - *Hospitalization
MH  - Humans
MH  - Life Support Care/*ethics
MH  - Qualitative Research
MH  - Thailand
MH  - Withholding Treatment/*ethics
EDAT- 2012/06/05 06:00
MHDA- 2012/10/27 06:00
CRDT- 2012/06/05 06:00
PHST- 2011/09/06 00:00 [received]
PHST- 2012/03/01 00:00 [revised]
PHST- 2012/03/06 00:00 [accepted]
PHST- 2012/06/05 06:00 [entrez]
PHST- 2012/06/05 06:00 [pubmed]
PHST- 2012/10/27 06:00 [medline]
AID - S0277-9536(12)00338-3 [pii]
AID - 10.1016/j.socscimed.2012.03.045 [doi]
PST - ppublish
SO  - Soc Sci Med. 2012 Sep;75(5):836-44. doi: 10.1016/j.socscimed.2012.03.045. Epub
      2012 May 2.


PMID- 22658623
OWN - NLM
STAT- MEDLINE
DCOM- 20121026
LR  - 20120626
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 75
IP  - 5
DP  - 2012 Sep
TI  - "They should take time": disclosure of clinical trial results as part of a social
      relationship.
PG  - 873-82
LID - 10.1016/j.socscimed.2012.04.022 [doi]
AB  - Disclosing overall scientific results to clinical trial participants has become
      an ethical obligation. Here we studied how participants understand these results 
      in view of their experience of clinical trials and illness in general and what
      modes of disclosure they preferred. Interviews were conducted with 29 breast
      cancer patients in France during 2009, using an in-depth qualitative approach.
      The findings obtained show that the "results" of research are understood quite
      differently by various patients depending on their expectations about clinical
      trials. Most of the women interviewed expected to receive personally tailored
      results at an individual encounter with their own clinical oncologist. Their
      preferred mode of disclosure was a consultation with their doctors because
      personal encounters promote mutual recognition and set up a symbolic process of
      exchange. The results of this study show that medical interventions should not be
      regarded solely from the technical point of view, but also in terms of the social
      relationships involved.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Sarradon-Eck, Aline
AU  - Sarradon-Eck A
AD  - GReCSS, Centre Norbert Elias, UMR8562, Aix-en-Provence, France.
      aline.sarradon@wanadoo.fr
FAU - Sakoyan, Juliette
AU  - Sakoyan J
FAU - Desclaux, Alice
AU  - Desclaux A
FAU - Mancini, Julien
AU  - Mancini J
FAU - Genre, Dominique
AU  - Genre D
FAU - Julian-Reynier, Claire
AU  - Julian-Reynier C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120517
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Adult
MH  - Aged
MH  - Breast Neoplasms/*therapy
MH  - *Clinical Trials as Topic
MH  - *Disclosure
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - *Physician-Patient Relations
MH  - Qualitative Research
EDAT- 2012/06/05 06:00
MHDA- 2012/10/27 06:00
CRDT- 2012/06/05 06:00
PHST- 2011/09/20 00:00 [received]
PHST- 2012/04/14 00:00 [revised]
PHST- 2012/04/17 00:00 [accepted]
PHST- 2012/06/05 06:00 [entrez]
PHST- 2012/06/05 06:00 [pubmed]
PHST- 2012/10/27 06:00 [medline]
AID - S0277-9536(12)00378-4 [pii]
AID - 10.1016/j.socscimed.2012.04.022 [doi]
PST - ppublish
SO  - Soc Sci Med. 2012 Sep;75(5):873-82. doi: 10.1016/j.socscimed.2012.04.022. Epub
      2012 May 17.


PMID- 22657389
OWN - NLM
STAT- MEDLINE
DCOM- 20130129
LR  - 20120913
IS  - 1545-293X (Electronic)
IS  - 1527-8204 (Linking)
VI  - 13
DP  - 2012
TI  - Genomic analysis of fetal nucleic acids in maternal blood.
PG  - 285-306
LID - 10.1146/annurev-genom-090711-163806 [doi]
AB  - The 15 years since the discovery of fetal DNA in maternal plasma have witnessed
      remarkable developments in noninvasive prenatal diagnosis. An understanding of
      biological parameters governing this phenomenon, such as the concentration and
      molecular size of circulating fetal DNA, has guided its diagnostic applications. 
      Early efforts focused on the detection of paternally inherited sequences, which
      were absent in the maternal genome, in maternal plasma. Recent developments in
      precise measurement technologies such as digital polymerase chain reaction (PCR) 
      have allowed the detection of minute allelic imbalances in plasma and have
      catalyzed analysis of single-gene disorders such as the hemoglobinopathies and
      hemophilia. The advent of massively parallel sequencing has enabled the robust
      detection of fetal trisomies in maternal plasma. Recent proof-of-concept studies 
      have detected a chromosomal translocation and a microdeletion and have deduced a 
      genome-wide genetic map of a fetus from maternal plasma. Understanding the
      ethical, legal, and social aspects in light of such rapid developments is thus a 
      priority for future research.
FAU - Lo, Yuk Ming Dennis
AU  - Lo YM
AD  - Li Ka Shing Institute of Health Sciences and Department of Chemical Pathology,
      Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New
      Territories, Hong Kong SAR, China. loym@cuhk.edu.hk
FAU - Chiu, Rossa Wai Kwun
AU  - Chiu RW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120529
PL  - United States
TA  - Annu Rev Genomics Hum Genet
JT  - Annual review of genomics and human genetics
JID - 100911346
RN  - 0 (Genetic Markers)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Aneuploidy
MH  - DNA/*blood
MH  - Female
MH  - Fetus/cytology
MH  - Genetic Diseases, Inborn/diagnosis/genetics
MH  - Genetic Markers
MH  - Genetic Testing
MH  - Genome, Human
MH  - Half-Life
MH  - Humans
MH  - Pregnancy
MH  - Prenatal Diagnosis
MH  - Sequence Analysis, DNA
EDAT- 2012/06/05 06:00
MHDA- 2013/01/30 06:00
CRDT- 2012/06/05 06:00
PHST- 2012/06/05 06:00 [entrez]
PHST- 2012/06/05 06:00 [pubmed]
PHST- 2013/01/30 06:00 [medline]
AID - 10.1146/annurev-genom-090711-163806 [doi]
PST - ppublish
SO  - Annu Rev Genomics Hum Genet. 2012;13:285-306. doi:
      10.1146/annurev-genom-090711-163806. Epub 2012 May 29.


PMID- 22656056
OWN - NLM
STAT- MEDLINE
DCOM- 20121023
LR  - 20120604
IS  - 1557-7740 (Electronic)
IS  - 1557-7740 (Linking)
VI  - 15
IP  - 6
DP  - 2012 Jun
TI  - Palliative sedation in Germany: how much do we know? A prospective survey.
PG  - 672-80
LID - 10.1089/jpm.2011.0395 [doi]
AB  - BACKGROUND: Little is known about the practice of palliative sedation (PS) in
      Germany. This paper presents an analysis of sedation-related data obtained from
      the German standardized core documentation system (HOPE) for palliative care
      patients. METHODS: HOPE was complemented by an optional module on ethical
      decision making (EDM) which was pretested in 2004, data was collected in 2005-6
      during the annual 3-month census. Data was analyzed descriptively from palliative
      care units (PCU - representative) and inpatient hospice (H - non-representative
      control group). Chi(2) test was used to test for differences between the reported
      data per item and year within one kind of setting (significance level p </=
      0.05). Free-text entries were categorized inductively. RESULTS: Datasets were
      obtained for 1,944 patients (P) with EDM. PS was performed in 13.0/11.8%
      (2005/2006) P in palliative care units (PCU) and 25.5/22.9% in hospices (H). Main
      reasons for PS in PCU were dyspnea, pain, fear or anxiety, in H reasons were
      inconsistent, high prevalence of psychosocial reasons. Most PS in PCU and about
      half of the PS in H were intermittent. Sedated P were younger than non-sedated.
      Only 7 P received PS after asking for euthanasia. The most used medication was
      midazolam. CONCLUSIONS: This study reveals a first insight into the use and
      practice of PS in German PCU and H. For a more detailed systematic survey into
      the course of decision-making and procedures, a new complementary optional module
      on PS is being developed by the HOPE group.
FAU - Jaspers, Birgit
AU  - Jaspers B
AD  - Department of Palliative Medicine, University of Bonn, Germany.
FAU - Nauck, Friedemann
AU  - Nauck F
FAU - Lindena, Gabriele
AU  - Lindena G
FAU - Elsner, Frank
AU  - Elsner F
FAU - Ostgathe, Christoph
AU  - Ostgathe C
FAU - Radbruch, Lukas
AU  - Radbruch L
LA  - eng
PT  - Journal Article
DEP - 20120321
PL  - United States
TA  - J Palliat Med
JT  - Journal of palliative medicine
JID - 9808462
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Deep Sedation
MH  - Female
MH  - Germany
MH  - Health Care Surveys
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Palliative Care
MH  - Prospective Studies
EDAT- 2012/06/05 06:00
MHDA- 2012/10/24 06:00
CRDT- 2012/06/05 06:00
PHST- 2012/06/05 06:00 [entrez]
PHST- 2012/06/05 06:00 [pubmed]
PHST- 2012/10/24 06:00 [medline]
AID - 10.1089/jpm.2011.0395 [doi]
PST - ppublish
SO  - J Palliat Med. 2012 Jun;15(6):672-80. doi: 10.1089/jpm.2011.0395. Epub 2012 Mar
      21.


PMID- 22656041
OWN - NLM
STAT- MEDLINE
DCOM- 20130225
LR  - 20181202
IS  - 1095-8673 (Electronic)
IS  - 0022-4804 (Linking)
VI  - 178
IP  - 2
DP  - 2012 Dec
TI  - Craniofacial repair with fetal bone grafts engineered from amniotic mesenchymal
      stem cells.
PG  - 785-90
LID - 10.1016/j.jss.2012.05.017 [doi]
LID - S0022-4804(12)00452-0 [pii]
AB  - BACKGROUND: Ethically acceptable applications of fetal tissue engineering as a
      perinatal therapy can be expanded beyond life-threatening anomalies by amniotic
      fluid cell-based methods, in which cell procurement poses no additional risk to
      the mother. We sought to start to determine whether osseous grafts engineered
      from amniotic mesenchymal stem cells (aMSCs) could be an adjunct to craniofacial 
      repair. METHODS: New Zealand rabbits (n = 12) underwent creation of a
      full-thickness diploic nasal bone defect. We then equally divided animals into
      two groups based on how the defect was repaired: namely, size-matched implants of
      electrospun biodegradable nanofibers with or without nuclear labeled, allogeneic 
      aMSCs maintained in osteogenic medium. We killed animals 8 wk post-implantation
      for multiple analyses. Statistical analysis included analysis of variance,
      post-hoc Bonferroni adjusted comparisons, and Levene's F-test, as appropriate (P 
      < 0.05), with significance set at P < 0.05. RESULTS: Micro-computed tomography
      scanning (two- and three-dimensional) showed no significant differences in defect
      radiodensity between groups. However, extracellular calcium levels were
      significantly higher in engineered grafts than in acellular implants (P = 0.003).
      There was significantly greater variability in mineralization in acellular
      implants than in engineered grafts by both direct calcium (P = 0.008) and
      micro-computed tomography measurements (P = 0.032). There were no significant
      differences in alkaline phosphatase activity or variance between groups. We
      documented labeled cells in the engineered grafts. CONCLUSIONS: Craniofacial
      repair with osseous grafts engineered from aMSCs lead to enhanced and more
      consistent mineralization compared with an equivalent acellular prosthetic
      repair. Amniotic fluid-derived engineered bone may become a practical adjunct to 
      perinatal craniofacial reconstruction.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Turner, Christopher G
AU  - Turner CG
AD  - Department of Surgery, Children's Hospital Boston and Harvard Medical School,
      Boston, Massachusetts 02115, USA.
FAU - Klein, Justin D
AU  - Klein JD
FAU - Gray, Fabienne L
AU  - Gray FL
FAU - Ahmed, Azra
AU  - Ahmed A
FAU - Zurakowski, David
AU  - Zurakowski D
FAU - Fauza, Dario O
AU  - Fauza DO
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120522
PL  - United States
TA  - J Surg Res
JT  - The Journal of surgical research
JID - 0376340
RN  - EC 3.1.3.1 (Alkaline Phosphatase)
SB  - IM
MH  - Alkaline Phosphatase/metabolism
MH  - Amniotic Fluid/*cytology
MH  - Animals
MH  - *Bone Transplantation
MH  - Craniofacial Abnormalities/surgery
MH  - Facial Bones/*surgery
MH  - *Fetal Tissue Transplantation
MH  - Mesenchymal Stem Cells/*cytology
MH  - Rabbits
MH  - Skull/*surgery
MH  - Tissue Engineering/*methods
MH  - Tomography, X-Ray Computed
EDAT- 2012/06/05 06:00
MHDA- 2013/02/26 06:00
CRDT- 2012/06/05 06:00
PHST- 2011/12/29 00:00 [received]
PHST- 2012/04/24 00:00 [revised]
PHST- 2012/05/03 00:00 [accepted]
PHST- 2012/06/05 06:00 [entrez]
PHST- 2012/06/05 06:00 [pubmed]
PHST- 2013/02/26 06:00 [medline]
AID - S0022-4804(12)00452-0 [pii]
AID - 10.1016/j.jss.2012.05.017 [doi]
PST - ppublish
SO  - J Surg Res. 2012 Dec;178(2):785-90. doi: 10.1016/j.jss.2012.05.017. Epub 2012 May
      22.


PMID- 22654931
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 2051-5545 (Electronic)
IS  - 1723-8617 (Linking)
VI  - 11
IP  - 2
DP  - 2012 Jun
TI  - The placebo response: science versus ethics and the vulnerability of the patient.
PG  - 70-2
FAU - Benedetti, Fabrizio
AU  - Benedetti F
AD  - Department of Neuroscience, University of Turin Medical School and National
      Institute of Neuroscience, Corso Raffaello 30, 10125 Turin, Italy.
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - World Psychiatry
JT  - World psychiatry : official journal of the World Psychiatric Association (WPA)
JID - 101189643
PMC - PMC3363375
EDAT- 2012/06/02 06:00
MHDA- 2012/06/02 06:01
CRDT- 2012/06/02 06:00
PHST- 2012/06/02 06:00 [entrez]
PHST- 2012/06/02 06:00 [pubmed]
PHST- 2012/06/02 06:01 [medline]
AID - 10.1016/j.wpsyc.2012.05.003 [doi]
PST - ppublish
SO  - World Psychiatry. 2012 Jun;11(2):70-2. doi: 10.1016/j.wpsyc.2012.05.003.


PMID- 22654918
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1687-9678 (Electronic)
VI  - 2012
DP  - 2012
TI  - Drug discovery models and toxicity testing using embryonic and induced
      pluripotent stem-cell-derived cardiac and neuronal cells.
PG  - 379569
LID - 10.1155/2012/379569 [doi]
AB  - Development of induced pluripotent stem cells (iPSCs) using forced expression of 
      specific sets of transcription factors has changed the field of stem cell
      research extensively. Two important limitations for research application of
      embryonic stem cells (ESCs), namely, ethical and immunological issues, can be
      circumvented using iPSCs. Since the development of first iPSCs, tremendous effort
      has been directed to the development of methods to increase the efficiency of the
      process and to reduce the extent of genomic modifications associated with the
      reprogramming procedure. The established lineage-specific differentiation
      protocols developed for ESCs are being applied to iPSCs, as they have great
      potential in regenerative medicine for cell therapy, disease modeling either for 
      drug development or for fundamental science, and, last but not least, toxicity
      testing. This paper reviews efforts aimed at practical development of iPSC
      differentiation to neural/cardiac lineages and further the use of these
      iPSCs-derived cells for drug development and toxicity testing.
FAU - Deshmukh, Rahul S
AU  - Deshmukh RS
AD  - BioTalentum Ltd., 2100 Godollo, Hungary.
FAU - Kovacs, Krisztian A
AU  - Kovacs KA
FAU - Dinnyes, Andras
AU  - Dinnyes A
LA  - eng
PT  - Journal Article
DEP - 20120508
PL  - United States
TA  - Stem Cells Int
JT  - Stem cells international
JID - 101535822
PMC - PMC3357635
EDAT- 2012/06/02 06:00
MHDA- 2012/06/02 06:01
CRDT- 2012/06/02 06:00
PHST- 2011/10/25 00:00 [received]
PHST- 2012/02/07 00:00 [revised]
PHST- 2012/02/16 00:00 [accepted]
PHST- 2012/06/02 06:00 [entrez]
PHST- 2012/06/02 06:00 [pubmed]
PHST- 2012/06/02 06:01 [medline]
AID - 10.1155/2012/379569 [doi]
PST - ppublish
SO  - Stem Cells Int. 2012;2012:379569. doi: 10.1155/2012/379569. Epub 2012 May 8.


PMID- 22653786
OWN - NLM
STAT- MEDLINE
DCOM- 20130423
LR  - 20161125
IS  - 1935-9780 (Electronic)
IS  - 1935-9772 (Linking)
VI  - 5
IP  - 6
DP  - 2012 Nov-Dec
TI  - Maximizing modern distribution of complex anatomical spatial information: 3D
      reconstruction and rapid prototype production of anatomical corrosion casts of
      human specimens.
PG  - 330-9
LID - 10.1002/ase.1287 [doi]
AB  - Anatomical corrosion casts of human specimens are useful teaching aids. However, 
      their use is limited due to ethical dilemmas associated with their production,
      their lack of perfect reproducibility, and their consumption of original
      specimens in the process of casting. In this study, new approaches with modern
      distribution of complex anatomical spatial information were explored to overcome 
      these limitations through the digitalization of anatomical casts of human
      specimens through three-dimensional (3D) reconstruction, rapid prototype
      production, and Web-based 3D atlas construction. The corrosion cast of a lung,
      along with its associated arteries, veins, trachea, and bronchial tree was
      CT-scanned, and the data was then processed by Mimics software. Data from the
      lung casts were then reconstructed into 3D models using a hybrid method,
      utilizing both "image threshold" and "region growing." The fine structures of the
      bronchial tree, arterial, and venous network of the lung were clearly displayed
      and demonstrated their distinct relationships. The multiple divisions of bronchi 
      and bronchopulmonary segments were identified. The 3D models were then uploaded
      into a rapid prototype 3D printer to physically duplicate the cast. The
      physically duplicated model of the lung was rescanned by CT and reconstructed to 
      detect its production accuracy. Gross observation and accuracy detection were
      used to evaluate the duplication and few differences were found. Finally, Virtual
      Reality Modeling Language (VRML) was used to edit the 3D casting models to
      construct a Web-based 3D atlas accessible through Internet Explorer with 3D
      display and annotation functions.
CI  - Copyright (c) 2012 American Association of Anatomists.
FAU - Li, Jianyi
AU  - Li J
AD  - Department of Anatomy, Guangdong Provincial Key Laboratory of Medical
      Biomechanics, Southern Medical University, Guangzhou, People's Republic of China.
FAU - Nie, Lanying
AU  - Nie L
FAU - Li, Zeyu
AU  - Li Z
FAU - Lin, Lijun
AU  - Lin L
FAU - Tang, Lei
AU  - Tang L
FAU - Ouyang, Jun
AU  - Ouyang J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120531
PL  - United States
TA  - Anat Sci Educ
JT  - Anatomical sciences education
JID - 101392205
SB  - IM
MH  - Anatomy/*education
MH  - *Anatomy, Artistic
MH  - *Atlases as Topic
MH  - *Computer Graphics
MH  - Computer Simulation
MH  - *Computer-Assisted Instruction
MH  - *Corrosion Casting
MH  - Curriculum
MH  - Humans
MH  - *Imaging, Three-Dimensional
MH  - Lung/*anatomy & histology/blood supply/diagnostic imaging
MH  - *Models, Anatomic
MH  - Software
MH  - Teaching/*methods
MH  - Tomography, X-Ray Computed
EDAT- 2012/06/02 06:00
MHDA- 2013/04/24 06:00
CRDT- 2012/06/02 06:00
PHST- 2011/10/09 00:00 [received]
PHST- 2012/02/12 00:00 [revised]
PHST- 2012/04/04 00:00 [accepted]
PHST- 2012/06/02 06:00 [entrez]
PHST- 2012/06/02 06:00 [pubmed]
PHST- 2013/04/24 06:00 [medline]
AID - 10.1002/ase.1287 [doi]
PST - ppublish
SO  - Anat Sci Educ. 2012 Nov-Dec;5(6):330-9. doi: 10.1002/ase.1287. Epub 2012 May 31.


PMID- 22653721
OWN - NLM
STAT- MEDLINE
DCOM- 20120731
LR  - 20120601
IS  - 0040-5930 (Print)
IS  - 0040-5930 (Linking)
VI  - 69
IP  - 6
DP  - 2012 Jun
TI  - [Communication with patients about medical incidents].
PG  - 363-6
LID - 10.1024/0040-5930/a000299 [doi]
AB  - Errors in medicine are common and often inevitable. They represent a dramatic
      situation for patients and their families. Thus, the physician-patient
      communication after a critical incident is crucial to prevent increased trauma.
      An error disclosure is a difficult, often overwhelming challenge for physicians. 
      Doctors commonly experience enormous pressures from patient advocates and
      ethicists, who encourage full disclosure while risk managers and liability
      insurers demand restraint. Despite increasing institutional and legal
      protections, physicians are still reluctant to disclose errors to their patients.
      And those error disclosures that do occur often fail to meet patients'
      expectations. In fact, there is a substantial gap between what patients want to
      hear and what physicians typically disclose. Previous research has proposed a
      series of verbal messages doctors should communicate during error disclosures.
      However, considering the emotional content of such messages, patients likely
      derive much of the meaning from physicians' nonverbal behaviors. This article
      presents a detailed review of the existing literature on this topic area and
      discusses the verbal and nonverbal components that constitute a competent error
      disclosure in the medical field.
FAU - Hannawa, A
AU  - Hannawa A
AD  - Institut fur Gesundheitskommunikation, Universitat Lugano, Lugano.
      annegret.hannawa@usi.ch
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Die Kommunikation nach einem Zwischenfall - Die Bedeutung des nonverbalen
      Verhaltens.
PL  - Switzerland
TA  - Ther Umsch
JT  - Therapeutische Umschau. Revue therapeutique
JID - 0407224
SB  - IM
MH  - Emotions
MH  - Humans
MH  - Malpractice
MH  - Medical Errors/*prevention & control
MH  - *Nonverbal Communication
MH  - *Physician-Patient Relations
MH  - Risk Management
MH  - Safety Management/*organization & administration
MH  - Switzerland
MH  - Task Performance and Analysis
MH  - Truth Disclosure
MH  - *Verbal Behavior
EDAT- 2012/06/02 06:00
MHDA- 2012/08/01 06:00
CRDT- 2012/06/02 06:00
PHST- 2012/06/02 06:00 [entrez]
PHST- 2012/06/02 06:00 [pubmed]
PHST- 2012/08/01 06:00 [medline]
AID - 10.1024/0040-5930/a000299 [doi]
PST - ppublish
SO  - Ther Umsch. 2012 Jun;69(6):363-6. doi: 10.1024/0040-5930/a000299.


PMID- 22652997
OWN - NLM
STAT- MEDLINE
DCOM- 20121107
LR  - 20211021
IS  - 1525-0024 (Electronic)
IS  - 1525-0016 (Linking)
VI  - 20
IP  - 6
DP  - 2012 Jun
TI  - Novel therapies, high-risk pediatric research, and the prospect of benefit:
      learning from the ethical disagreements.
PG  - 1095-102
LID - 10.1038/mt.2012.90 [doi]
FAU - de Melo-Martin, Inmaculada
AU  - de Melo-Martin I
AD  - Division of Medical Ethics, Department of Public Health, Weill Cornell Medical
      College, New York, New York 10065, USA.
FAU - Sondhi, Dolan
AU  - Sondhi D
FAU - Crystal, Ronald G
AU  - Crystal RG
LA  - eng
GR  - R01 NS061848/NS/NINDS NIH HHS/United States
GR  - R01 NS061848-01A2/NS/NINDS NIH HHS/United States
GR  - 1R01NS061848/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Mol Ther
JT  - Molecular therapy : the journal of the American Society of Gene Therapy
JID - 100890581
SB  - IM
MH  - Biomedical Research/ethics/legislation & jurisprudence
MH  - Child
MH  - Clinical Trials, Phase I as Topic/*ethics
MH  - Ethics, Research
MH  - Genetic Therapy/*ethics
MH  - Humans
MH  - Risk Assessment
PMC - PMC3369294
EDAT- 2012/06/02 06:00
MHDA- 2012/11/08 06:00
CRDT- 2012/06/02 06:00
PHST- 2012/06/02 06:00 [entrez]
PHST- 2012/06/02 06:00 [pubmed]
PHST- 2012/11/08 06:00 [medline]
AID - S1525-0016(16)32531-X [pii]
AID - 10.1038/mt.2012.90 [doi]
PST - ppublish
SO  - Mol Ther. 2012 Jun;20(6):1095-102. doi: 10.1038/mt.2012.90.


PMID- 22651852
OWN - NLM
STAT- MEDLINE
DCOM- 20121029
LR  - 20151119
IS  - 1533-2500 (Electronic)
IS  - 1530-7085 (Linking)
VI  - 12
IP  - 6
DP  - 2012 Jul
TI  - Functional and patient-reported outcomes in symptomatic lumbar spinal stenosis
      following percutaneous decompression.
PG  - 417-25
LID - 10.1111/j.1533-2500.2012.00565.x [doi]
AB  - BACKGROUND: Neurogenic claudication due to symptomatic lumbar spinal stenosis
      (LSS) is a painful condition causing significant functional disability. While the
      cause of LSS is multifactorial, thickened ligamentum flavum (LF) accounts for up 
      to 85% of spinal canal narrowing. mild percutaneous lumbar decompression allows
      debulking of the hypertrophic LF while avoiding the morbidities frequently
      associated with more invasive surgical procedures. METHODS: In this prospective
      case series study, consecutive LSS patients presenting with neurogenic
      claudication were treated with percutaneous lumbar decompression. Efficacy was
      evaluated using the Pain Disability Index (PDI) and Roland-Morris Disability
      Questionnaire. Pre- and postprocedure Standing Time, Walking Distance, and Visual
      Analog Score (VAS) were also monitored. Significant device- or procedure-related 
      adverse events were reported. RESULTS: The mild procedure was successfully
      performed on forty patients. At twelve months, both PDI and Roland-Morris showed 
      significant improvement of 22.6 points (ANOVA, P<0.0001) and 7.7 points (ANOVA,
      P<0.0001), respectively. Walking Distance, Standing Time, and VAS improvements
      were also statistically significant, increasing from 246 to 3,956 feet (ANOVA,
      P<0.0001), 8 to 56 minutes (ANOVA, P<0.0001), and 7.1 to 3.6 points (ANOVA,
      P<0.0001), respectively. Tukey HSD test found improvement in all 5-outcome
      measures to be significant from baseline at each follow-up interval. No
      significant device- or procedure-related adverse events were reported.
      CONCLUSION: This study demonstrated significant functional improvement as well as
      decreased disability secondary to neurogenic claudication after mild procedure.
      Safety, cost-effectiveness, and quality-of-life outcomes are best compared with
      comprehensive medical management in a randomized controlled fashion and, where
      ethical, to open lumbar decompression surgery.
CI  - (c) 2012 The Authors. Pain Practice (c) 2012 World Institute of Pain.
FAU - Mekhail, Nagy
AU  - Mekhail N
AD  - Department of Pain Management, Cleveland Clinic, Cleveland, Ohio 44195, USA.
      mekhain@ccf.org
FAU - Costandi, Shrif
AU  - Costandi S
FAU - Abraham, Benjamin
AU  - Abraham B
FAU - Samuel, Samuel Wadie
AU  - Samuel SW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120601
PL  - United States
TA  - Pain Pract
JT  - Pain practice : the official journal of World Institute of Pain
JID - 101130835
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Decompression, Surgical/*methods
MH  - Female
MH  - Humans
MH  - Ligamentum Flavum/*surgery
MH  - Low Back Pain/etiology/*surgery
MH  - Lower Extremity
MH  - *Lumbar Vertebrae
MH  - Male
MH  - Middle Aged
MH  - Pain Measurement
MH  - Patient Satisfaction
MH  - Prospective Studies
MH  - Spinal Stenosis/complications/*surgery
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
EDAT- 2012/06/02 06:00
MHDA- 2012/10/30 06:00
CRDT- 2012/06/02 06:00
PHST- 2012/06/02 06:00 [entrez]
PHST- 2012/06/02 06:00 [pubmed]
PHST- 2012/10/30 06:00 [medline]
AID - 10.1111/j.1533-2500.2012.00565.x [doi]
PST - ppublish
SO  - Pain Pract. 2012 Jul;12(6):417-25. doi: 10.1111/j.1533-2500.2012.00565.x. Epub
      2012 Jun 1.


PMID- 22650465
OWN - NLM
STAT- MEDLINE
DCOM- 20120910
LR  - 20181201
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 12
IP  - 6
DP  - 2012
TI  - The ethical status of prophylactic interventions in children: ovarian tissue
      cryopreservation and vaccination.
PG  - 50-2
LID - 10.1080/15265161.2012.671899 [doi]
FAU - Ungar, Leo D J
AU  - Ungar LD
AD  - Stanford Center for Biomedical Ethics, Stanford, CA, 94305 USA.
FAU - Ladd, Jennifer M
AU  - Ladd JM
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2012;12(6):38-43. PMID: 22650461
MH  - *Cryopreservation
MH  - Decision Making/*ethics
MH  - Female
MH  - Humans
MH  - Infertility, Female/*prevention & control
MH  - *Mothers
MH  - *Ovary
MH  - *Principle-Based Ethics
MH  - Reproductive Rights/*ethics
EDAT- 2012/06/02 06:00
MHDA- 2012/09/11 06:00
CRDT- 2012/06/02 06:00
PHST- 2012/06/02 06:00 [entrez]
PHST- 2012/06/02 06:00 [pubmed]
PHST- 2012/09/11 06:00 [medline]
AID - 10.1080/15265161.2012.671899 [doi]
PST - ppublish
SO  - Am J Bioeth. 2012;12(6):50-2. doi: 10.1080/15265161.2012.671899.


PMID- 22650461
OWN - NLM
STAT- MEDLINE
DCOM- 20120910
LR  - 20211021
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 12
IP  - 6
DP  - 2012
TI  - Preserving the right to future children: an ethical case analysis.
PG  - 38-43
LID - 10.1080/15265161.2012.673688 [doi]
AB  - We report on the case of a 2-year-old female, the youngest person ever to undergo
      ovarian tissue cryopreservation (OTC). This patient was diagnosed with a rare
      form of sickle cell disease, which required a bone-marrow transplant, and late
      effects included high risk of future infertility or complete sterility. Ethical
      concerns are raised, as the patient's mother made the decision for OTC on the
      patient's behalf with the intention that this would secure the option of
      biological childbearing in the future. Based on Beauchamp and Childress's
      principlism approach of respect for autonomy, nonmaleficence, beneficence, and
      justice, pursing OTC was ethically justified.
FAU - Quinn, Gwendolyn P
AU  - Quinn GP
AD  - Moffitt Cancer Center, Health Outcomes and Behavior Program, Tampa, FL 33612,
      USA. gwen.quinn@moffitt.org
FAU - Stearsman, Daniel K
AU  - Stearsman DK
FAU - Campo-Engelstein, Lisa
AU  - Campo-Engelstein L
FAU - Murphy, Devin
AU  - Murphy D
LA  - eng
GR  - RL1 HD058296/HD/NICHD NIH HHS/United States
GR  - UL1 DE019587/DE/NIDCR NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CIN - Am J Bioeth. 2012;12(6):44-5. PMID: 22650462
CIN - Am J Bioeth. 2012;12(6):46-7. PMID: 22650463
CIN - Am J Bioeth. 2012;12(6):48-9. PMID: 22650464
CIN - Am J Bioeth. 2012;12(6):50-2. PMID: 22650465
CIN - Am J Bioeth. 2012;12(6):52-3. PMID: 22650466
CIN - Am J Bioeth. 2012;12(6):53-5. PMID: 22650467
MH  - Anemia, Sickle Cell/surgery
MH  - Beneficence
MH  - Bone Marrow Transplantation/adverse effects
MH  - Child, Preschool
MH  - *Cryopreservation/ethics
MH  - Decision Making/*ethics
MH  - Ethical Analysis
MH  - Female
MH  - Humans
MH  - Infertility, Female/etiology/*prevention & control
MH  - *Mothers
MH  - Nuclear Family
MH  - *Ovary
MH  - Personal Autonomy
MH  - *Principle-Based Ethics
MH  - Reproductive Rights/*ethics
MH  - Social Justice
PMC - PMC3642619
MID - NIHMS459147
EDAT- 2012/06/02 06:00
MHDA- 2012/09/11 06:00
CRDT- 2012/06/02 06:00
PHST- 2012/06/02 06:00 [entrez]
PHST- 2012/06/02 06:00 [pubmed]
PHST- 2012/09/11 06:00 [medline]
AID - 10.1080/15265161.2012.673688 [doi]
PST - ppublish
SO  - Am J Bioeth. 2012;12(6):38-43. doi: 10.1080/15265161.2012.673688.


PMID- 22650459
OWN - NLM
STAT- MEDLINE
DCOM- 20120910
LR  - 20181201
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 12
IP  - 6
DP  - 2012
TI  - The devil in the details: thorough assessment of evidence and ethics is needed in
      evaluating new HIV prevention methods.
PG  - 33-4
LID - 10.1080/15265161.2012.672621 [doi]
FAU - Dawson, Liza
AU  - Dawson L
AD  - National Institutes of Health, Bethesda, MD 20817, USA. dawsonl@niaid.nih.gov
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
RN  - 0 (Anti-HIV Agents)
SB  - IM
CON - Am J Bioeth. 2012;12(6):21-30. PMID: 22650457
MH  - Anti-HIV Agents/*therapeutic use
MH  - *Ethics, Research
MH  - Female
MH  - HIV Infections/*prevention & control
MH  - Health Services Accessibility/*ethics
MH  - *Homosexuality, Male
MH  - Humans
MH  - Male
MH  - Primary Prevention/*ethics
MH  - *Therapeutic Equipoise
EDAT- 2012/06/02 06:00
MHDA- 2012/09/11 06:00
CRDT- 2012/06/02 06:00
PHST- 2012/06/02 06:00 [entrez]
PHST- 2012/06/02 06:00 [pubmed]
PHST- 2012/09/11 06:00 [medline]
AID - 10.1080/15265161.2012.672621 [doi]
PST - ppublish
SO  - Am J Bioeth. 2012;12(6):33-4. doi: 10.1080/15265161.2012.672621.


PMID- 22650458
OWN - NLM
STAT- MEDLINE
DCOM- 20120910
LR  - 20181201
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 12
IP  - 6
DP  - 2012
TI  - Ethics in HIV prevention research: clarifying the complexities.
PG  - 31-2
LID - 10.1080/15265161.2012.671889 [doi]
FAU - Macklin, Ruth
AU  - Macklin R
AD  - Albert Einstein College of Medicine, Bronx, NY 10461, USA.
      ruth.macklin@einstein.yu.edu
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
RN  - 0 (Anti-HIV Agents)
SB  - IM
CON - Am J Bioeth. 2012;12(6):21-30. PMID: 22650457
MH  - Anti-HIV Agents/*therapeutic use
MH  - *Ethics, Research
MH  - Female
MH  - HIV Infections/*prevention & control
MH  - Health Services Accessibility/*ethics
MH  - *Homosexuality, Male
MH  - Humans
MH  - Male
MH  - Primary Prevention/*ethics
MH  - *Therapeutic Equipoise
EDAT- 2012/06/02 06:00
MHDA- 2012/09/11 06:00
CRDT- 2012/06/02 06:00
PHST- 2012/06/02 06:00 [entrez]
PHST- 2012/06/02 06:00 [pubmed]
PHST- 2012/09/11 06:00 [medline]
AID - 10.1080/15265161.2012.671889 [doi]
PST - ppublish
SO  - Am J Bioeth. 2012;12(6):31-2. doi: 10.1080/15265161.2012.671889.


PMID- 22650452
OWN - NLM
STAT- MEDLINE
DCOM- 20120910
LR  - 20181201
IS  - 1536-0075 (Electronic)
IS  - 1526-5161 (Linking)
VI  - 12
IP  - 6
DP  - 2012
TI  - Going all the way: ethical clarity and ethical progress.
PG  - 10-1
LID - 10.1080/15265161.2012.671890 [doi]
FAU - Miller, Franklin G
AU  - Miller FG
AD  - National Institutes of Health, Bethesda, MD 20892, USA. fmiller@nih.gov
FAU - Truog, Robert D
AU  - Truog RD
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am J Bioeth
JT  - The American journal of bioethics : AJOB
JID - 100898738
SB  - IM
CON - Am J Bioeth. 2012;12(6):1-8. PMID: 22650450
MH  - *Brain Injuries
MH  - *Family
MH  - Humans
MH  - *Living Donors
MH  - Male
MH  - Nephrectomy/*ethics
MH  - Organ Transplantation/*ethics
MH  - *Public Opinion
MH  - *Respiration, Artificial
MH  - Terminal Care/*ethics
MH  - *Third-Party Consent
MH  - Tissue and Organ Harvesting/*ethics
MH  - Tissue and Organ Procurement/*ethics
MH  - *Trust
MH  - Withholding Treatment/*ethics
EDAT- 2012/06/02 06:00
MHDA- 2012/09/11 06:00
CRDT- 2012/06/02 06:00
PHST- 2012/06/02 06:00 [entrez]
PHST- 2012/06/02 06:00 [pubmed]
PHST- 2012/09/11 06:00 [medline]
AID - 10.1080/15265161.2012.671890 [doi]
PST - ppublish
SO  - Am J Bioeth. 2012;12(6):10-1. doi: 10.1080/15265161.2012.671890.


PMID- 22649182
OWN - NLM
STAT- MEDLINE
DCOM- 20140404
LR  - 20220129
IS  - 1468-3318 (Electronic)
IS  - 0964-4563 (Linking)
VI  - 22
IP  - 5
DP  - 2013 Sep
TI  - Dispelling myths about gender differences in smoking cessation: population data
      from the USA, Canada and Britain.
PG  - 356-60
LID - 10.1136/tobaccocontrol-2011-050279 [doi]
AB  - OBJECTIVES: Based mainly on findings from clinical settings, it has been claimed 
      that women are less likely than men to quit smoking successfully. If true, this
      would have important implications for tobacco control interventions. The authors 
      aimed to test this possibility using data from general population surveys.
      METHODS: The authors used data from major national surveys conducted in 2006-2007
      in the USA (Tobacco Use Supplement to the Current Population Survey), Canada
      (Canadian Tobacco Use Monitoring Survey) and the UK (General Household Survey) to
      estimate rates of smoking cessation by age in men and women. RESULTS: The authors
      found a pattern of gender differences in smoking cessation which was consistent
      across countries. Below age 50, women were more likely to have given up smoking
      completely than men, while among older age groups, men were more likely to have
      quit than women. Across all age groups, there was relatively little difference in
      cessation between the sexes. CONCLUSIONS: Conclusions about gender differences in
      smoking cessation should be based on evidence from the general population rather 
      than from atypical clinical samples. This study has found convincing evidence
      that men in general are not more likely to quit smoking successfully than women.
FAU - Jarvis, Martin J
AU  - Jarvis MJ
AD  - Department of Epidemiology and Public Health, University College London, London, 
      UK. martin.jarvis@ucl.ac.uk
FAU - Cohen, Joanna E
AU  - Cohen JE
FAU - Delnevo, Cristine D
AU  - Delnevo CD
FAU - Giovino, Gary A
AU  - Giovino GA
LA  - eng
GR  - 14135/CRUK_/Cancer Research UK/United Kingdom
PT  - Journal Article
DEP - 20120530
PL  - England
TA  - Tob Control
JT  - Tobacco control
JID - 9209612
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Canada/epidemiology
MH  - *Epidemiologic Research Design
MH  - Female
MH  - Health Surveys
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Sex Factors
MH  - Smoking/*epidemiology
MH  - Smoking Cessation/*statistics & numerical data
MH  - Tobacco Use Disorder
MH  - United Kingdom/epidemiology
MH  - United States/epidemiology
MH  - Young Adult
OTO - NOTNLM
OT  - Smoking cessation
OT  - advertising and promotion
OT  - cessation
OT  - environment
OT  - environmental tobacco smoke
OT  - ethics
OT  - evaluation
OT  - gender
OT  - harm reduction
OT  - ideology
OT  - non-cigarette tobacco products
OT  - policymakers
OT  - prevalence
OT  - quit ratios
OT  - smoking-caused disease
OT  - surveillance
OT  - surveillance and monitoring
EDAT- 2012/06/01 06:00
MHDA- 2014/04/05 06:00
CRDT- 2012/06/01 06:00
PHST- 2012/06/01 06:00 [entrez]
PHST- 2012/06/01 06:00 [pubmed]
PHST- 2014/04/05 06:00 [medline]
AID - tobaccocontrol-2011-050279 [pii]
AID - 10.1136/tobaccocontrol-2011-050279 [doi]
PST - ppublish
SO  - Tob Control. 2013 Sep;22(5):356-60. doi: 10.1136/tobaccocontrol-2011-050279. Epub
      2012 May 30.


PMID- 22649177
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 3
DP  - 2012
TI  - Focused sonographic examination of the heart, lungs and deep veins in an
      unselected population of acute admitted patients with respiratory symptoms: a
      protocol for a prospective, blinded, randomised controlled trial.
LID - 10.1136/bmjopen-2012-001369 [doi]
LID - e001369 [pii]
AB  - INTRODUCTION: Patients admitted to hospital with acute respiratory symptoms
      remain a diagnostic challenge for the emergency physician. The use of focused
      sonography may improve the initial diagnostics, as most of the diseases, commonly
      seen and misdiagnosed in patients with acute respiratory symptoms, can be
      diagnosed with sonography. The protocol describes a prospective, blinded,
      randomised controlled trial that aims to assess the diagnostic impact of a
      pragmatic implementation of focused sonography of the heart, lungs and deep veins
      as a diagnostic modality in acute admitted patients with respiratory symptoms.
      METHODS AND ANALYSIS: The primary outcome of the study is the number of patients 
      with a correct presumptive diagnosis within 4 h of admission to the emergency
      department. The patient is randomised to either an intervention or a control
      group. In the intervention group, the usual initial diagnostic work up is
      supplemented by focused sonographic examination of the heart, lungs and deep
      veins of the legs. In the control group, usual diagnostic work up is performed.
      The chi(2) test, alternatively the Fischer exact test will be used, to establish 
      whether there is a difference in the distribution of the total number of patients
      with a correct/incorrect '4 h' presumptive diagnosis in the control group and in 
      the intervention group. ETHICS AND DISSEMINATION: This clinical trial is
      performed according to the Declaration of Helsinki and has been approved by the
      Regional Scientific Ethical Committee for Southern Denmark and the Danish Data
      Protection Agency. The results of the trial will be published according to the
      CONSORT statement with the extension for pragmatic trials. The results of the
      trial will be published in a peer-reviewed scientific journal regardless of the
      outcome. TRIAL REGISTRATION NUMBER: This study is registered at
      http://clinicaltrials.gov, registration number NCT01486394.
FAU - Laursen, Christian Borbjerg
AU  - Laursen CB
AD  - Research Unit at the Department of Respiratory Medicine, Odense University
      Hospital, Odense C, Denmark.
FAU - Sloth, Erik
AU  - Sloth E
FAU - Lassen, Annmarie Touborg
AU  - Lassen AT
FAU - Christensen, Rene Depont
AU  - Christensen RD
FAU - Lambrechtsen, Jess
AU  - Lambrechtsen J
FAU - Madsen, Poul Henning
AU  - Madsen PH
FAU - Henriksen, Daniel Pilsgaard
AU  - Henriksen DP
FAU - Davidsen, Jesper Romhild
AU  - Davidsen JR
FAU - Rasmussen, Finn
AU  - Rasmussen F
LA  - eng
SI  - ClinicalTrials.gov/NCT01486394
PT  - Journal Article
DEP - 20120530
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3367153
EDAT- 2012/06/01 06:00
MHDA- 2012/06/01 06:01
CRDT- 2012/06/01 06:00
PHST- 2012/06/01 06:00 [entrez]
PHST- 2012/06/01 06:00 [pubmed]
PHST- 2012/06/01 06:01 [medline]
AID - bmjopen-2012-001369 [pii]
AID - 10.1136/bmjopen-2012-001369 [doi]
PST - epublish
SO  - BMJ Open. 2012 May 30;2(3). pii: bmjopen-2012-001369. doi:
      10.1136/bmjopen-2012-001369. Print 2012.


PMID- 22649171
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20220318
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 3
DP  - 2012
TI  - What potential research participants want to know about research: a systematic
      review.
LID - 10.1136/bmjopen-2011-000509 [doi]
LID - e000509 [pii]
AB  - OBJECTIVE: To establish the empirical evidence base for the information that
      participants want to know about medical research and to assess how this relates
      to current guidance from the National Research Ethics Service (NRES). DATA
      SOURCES: Medline, Web of Science, Applied Social Sciences Index and Abstracts,
      Sociological abstracts, Health Management Information Consortium, Cochrane
      Library, thesis index's, grey literature databases, reference and cited article
      lists, key journals, Google Scholar and correspondence with expert authors. STUDY
      SELECTION: Original research studies published between 1950 and October 2010 that
      asked potential participants to indicate how much or what types of information
      they wanted to be told about a research study or asked them to rate the
      importance of a specific piece of information were included. STUDY APPRAISAL AND 
      SYNTHESIS METHODS: Studies were appraised based on the generalisability of
      results to the UK potential research participant population. A metadata analysis 
      using basic thematic analysis was used to split results from papers into themes
      based on the sections of information that NRES recommends should be included in a
      participant information sheet. RESULTS: 14 studies were included. Of the 20
      pieces of information that NRES recommend should be included in patient
      information sheets for research pooled proportions could be calculated for seven 
      themes. Results showed that potential participants wanted to be offered
      information about result dissemination (91% (95% CI 85% to 95%)), investigator
      conflicts of interest (48% (95% CI 27% to 69%)), the purpose of the study (76%
      (95% CI 27% to 100%)), voluntariness (39% (95% CI 2% to 100%)), how long the
      research would last (61% (95% CI 16% to 97%)), potential benefits (57% (95% CI 7%
      to 98%)) and confidentiality (44% (95% CI 10% to 82%)). The level of detail
      participants wanted to know was not explored comprehensively in the studies.
      There was no empirical evidence to support the level of information provision
      required by participants on the remaining seven items. CONCLUSIONS: There is
      limited empirical evidence on what potential participants want to know about
      research. The existing empirical evidence suggests that individuals may have very
      different needs and a more tailored evidence-based approach may be necessary.
FAU - Kirkby, Helen Michelle
AU  - Kirkby HM
AD  - MRC Midlands Hub for Trials Methodology Research (HTMR), University of
      Birmingham, Edgbaston, Birmingham, UK.
FAU - Calvert, Melanie
AU  - Calvert M
FAU - Draper, Heather
AU  - Draper H
FAU - Keeley, Thomas
AU  - Keeley T
FAU - Wilson, Sue
AU  - Wilson S
LA  - eng
GR  - G0800808/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
DEP - 20120530
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3367142
EDAT- 2012/06/01 06:00
MHDA- 2012/06/01 06:01
CRDT- 2012/06/01 06:00
PHST- 2012/06/01 06:00 [entrez]
PHST- 2012/06/01 06:00 [pubmed]
PHST- 2012/06/01 06:01 [medline]
AID - bmjopen-2011-000509 [pii]
AID - 10.1136/bmjopen-2011-000509 [doi]
PST - epublish
SO  - BMJ Open. 2012 May 30;2(3). pii: bmjopen-2011-000509. doi:
      10.1136/bmjopen-2011-000509. Print 2012.


PMID- 22648781
OWN - NLM
STAT- MEDLINE
DCOM- 20120919
LR  - 20211203
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Linking)
VI  - 891
DP  - 2012
TI  - Risks, benefits and ethical, legal, and societal considerations for translation
      of prenatal gene therapy to human application.
PG  - 371-87
LID - 10.1007/978-1-61779-873-3_17 [doi]
AB  - The still experimental nature of prenatal gene therapy carries a certain degree
      of risk, both for the pregnant mother as well as for the fetus. Some of the risks
      are procedural hazards already known from more conventional fetal medicine
      interventions. Others are more specific to gene therapy such as the potential for
      interference with normal fetal development, the possibility of inadvertent germ
      line gene transfer, and the danger of oncogenesis. This chapter reviews the
      potential risks in relation to the expected benefits of prenatal gene therapy. It
      discusses the scientific, ethical, legal, and social implications of this novel
      preventive approach to genetic disease and outlines preconditions to be met in
      preparation for a potential future clinical application.
FAU - Coutelle, Charles
AU  - Coutelle C
AD  - National Heart and Lung Institute, Molecular and Cellular Medicine Section,
      Imperial College London, London, UK. c.coutelle@imperial.ac.uk
FAU - Ashcroft, Richard
AU  - Ashcroft R
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
SB  - IM
MH  - Genetic Therapy/*ethics/*legislation & jurisprudence
MH  - Humans
MH  - Prenatal Care/ethics
MH  - Risk Assessment
MH  - Risk Factors
MH  - *Sociology, Medical
MH  - Translational Research, Biomedical/*ethics/*legislation & jurisprudence
EDAT- 2012/06/01 06:00
MHDA- 2012/09/20 06:00
CRDT- 2012/06/01 06:00
PHST- 2012/06/01 06:00 [entrez]
PHST- 2012/06/01 06:00 [pubmed]
PHST- 2012/09/20 06:00 [medline]
AID - 10.1007/978-1-61779-873-3_17 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2012;891:371-87. doi: 10.1007/978-1-61779-873-3_17.


PMID- 22648765
OWN - NLM
STAT- MEDLINE
DCOM- 20120919
LR  - 20211203
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Linking)
VI  - 891
DP  - 2012
TI  - The concept of prenatal gene therapy.
PG  - 1-7
LID - 10.1007/978-1-61779-873-3_1 [doi]
AB  - This introductory chapter provides a short review of the ideas and practical
      approaches that have led to the present and perceived future development of
      prenatal gene therapy. It summarizes the advantages and the potential adverse
      effects of this novel preventive and therapeutic approach to the management of
      prenatal diseases. It also provides guidance to the range of conditions to which 
      prenatal gene therapy may be applied and to the technical approaches, vectors,
      and societal/ethical considerations for this newly emerging field of Fetal
      Medicine.
FAU - Coutelle, Charles
AU  - Coutelle C
AD  - National Heart and Lung Institute, Molecular and Cellular Medicine Section,
      Imperial College London, London, UK. c.coutelle@imperial.ac.uk
FAU - Waddington, Simon N
AU  - Waddington SN
LA  - eng
PT  - Introductory Journal Article
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
SB  - IM
MH  - Animals
MH  - Gene Transfer Techniques/adverse effects
MH  - Genetic Therapy/adverse effects/*methods
MH  - Genetic Vectors/genetics
MH  - Humans
MH  - Prenatal Care/*methods
MH  - Prenatal Diagnosis
MH  - Reproducibility of Results
MH  - Translational Research, Biomedical
EDAT- 2012/06/01 06:00
MHDA- 2012/09/20 06:00
CRDT- 2012/06/01 06:00
PHST- 2012/06/01 06:00 [entrez]
PHST- 2012/06/01 06:00 [pubmed]
PHST- 2012/09/20 06:00 [medline]
AID - 10.1007/978-1-61779-873-3_1 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2012;891:1-7. doi: 10.1007/978-1-61779-873-3_1.


PMID- 22648746
OWN - NLM
STAT- MEDLINE
DCOM- 20130111
LR  - 20120823
IS  - 1097-0029 (Electronic)
IS  - 1059-910X (Linking)
VI  - 75
IP  - 9
DP  - 2012 Sep
TI  - Steroid hormone receptors, matrix metalloproteinases, insulin-like growth factor,
      and dystroglycans interactions in prostatic diseases in the elderly men.
PG  - 1197-205
LID - 10.1002/jemt.22049 [doi]
AB  - OBJECTIVES: The aim of this study was to evaluate the reactivity of steroid
      hormone receptors (SHRs), dystroglycans (DGs), matrix metalloproteinases (MMPs), 
      insulin-like growth factor receptor (IGFR-1), and laminin (Lam) in both prostatic
      stromal and epithelial compartments showing different diseases in elderly men.
      METHODS: Sixty prostatic samples were obtained from 60- to 90-year-old patients
      (mean 63 years) with and without prostatic lesions from Hospital of the School of
      Medicine, State University of Campinas (UNICAMP). The Samples were divided into
      standard (no lesions); high grade prostatic intraepithelial neoplasia (HGPIN);
      prostatic cancer (PC); and benign prostatic hyperplasia (BPH) groups. The samples
      were submitted to immunohistochemistry and Western blotting analyses. Research
      Ethics Committee of the School of Medicine, University of Campinas/UNICAMP
      (number 0094.0.146.000-08). RESULTS: The results showed increased IGFR-1 and MMPs
      protein levels in the PC and HGPIN groups. Decreased alphaDG and betaDG protein
      levels were verified in the PC and HGPIN groups. Androgen receptor (AR)
      reactivity was similar among all groups. Estrogen receptor alpha (Eralpha)
      immunoreactivity was more intense in the epithelium in the PC and HGPIN groups.
      Estrogen receptor beta (ERbeta) immunoreactivity was weak in the epithelium of
      the HGPIN and PC groups. CONCLUSIONS: To conclude, there was an association among
      IGFR-1, MMPs, and SHRs, indicating IGFR-1 as a target molecule in prostate
      therapy, considering the IGF proliferative properties. Also, the distinct SHRs
      reactivities in the lesions in both prostatic compartments indicated different
      paracrine signals and pointed out the importance of estrogenic pathways in the
      activation of these disorders.
CI  - Copyright (c) 2012 Wiley Periodicals, Inc.
FAU - Hetzl, A C
AU  - Hetzl AC
AD  - Department of Structural and Functional Biology, Institute of Biology, State
      University of Campinas-UNICAMP, Campinas, SP, Brazil.
FAU - Favaro, W J
AU  - Favaro WJ
FAU - Billis, A
AU  - Billis A
FAU - Ferreira, U
AU  - Ferreira U
FAU - Cagnon, V H A
AU  - Cagnon VH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120531
PL  - United States
TA  - Microsc Res Tech
JT  - Microscopy research and technique
JID - 9203012
RN  - 0 (Laminin)
RN  - 0 (Receptors, Steroid)
RN  - 0 (Somatomedins)
RN  - 146888-27-9 (Dystroglycans)
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging
MH  - Blotting, Western
MH  - Dystroglycans/*analysis
MH  - Humans
MH  - Immunohistochemistry
MH  - Laminin/analysis
MH  - Male
MH  - Matrix Metalloproteinases/*analysis
MH  - Middle Aged
MH  - Prostate/pathology
MH  - Prostatic Diseases/*pathology
MH  - Receptors, Steroid/*analysis
MH  - Somatomedins/*analysis
EDAT- 2012/06/01 06:00
MHDA- 2013/01/12 06:00
CRDT- 2012/06/01 06:00
PHST- 2011/12/14 00:00 [received]
PHST- 2012/03/13 00:00 [accepted]
PHST- 2012/06/01 06:00 [entrez]
PHST- 2012/06/01 06:00 [pubmed]
PHST- 2013/01/12 06:00 [medline]
AID - 10.1002/jemt.22049 [doi]
PST - ppublish
SO  - Microsc Res Tech. 2012 Sep;75(9):1197-205. doi: 10.1002/jemt.22049. Epub 2012 May
      31.


PMID- 22648585
OWN - NLM
STAT- MEDLINE
DCOM- 20121127
LR  - 20120531
IS  - 0015-5659 (Print)
IS  - 0015-5659 (Linking)
VI  - 71
IP  - 2
DP  - 2012 May
TI  - The use of computer-assisted image analysis in measuring the histological
      structure of the human median nerve.
PG  - 82-5
AB  - BACKGROUND AND AIM: The aim of this study was to assess the histological
      structure of the median nerve and its motor branch (number and arrangement of
      nerve bundles) and the cross-sectional area (CSA) of the median nerve (on the
      level of the carpal tunnel). MATERIAL AND METHODS: This study has been conducted 
      using median nerves dissected from cadavers stored in a 10% solution of
      formaldehyde at the Department of Anatomy of the Jagiellonian University Medical 
      College and cadavers from the Department of Forensic Medicine of the Jagiellonian
      University Medical College. After dissection the median nerves were stained with 
      haematoxylin and eosin and histological slides were prepared. These were later
      photographed (16 x magnification) and analysed using ImageJ software. The
      research protocol was approved by the Jagiellonian University Ethics Committee
      (registry KBET/209/B/2002). RESULTS: The studied group comprised 8 women and 22
      men (age between 23-92 years), yielding a total of 60 median nerves (30 right vs.
      30 left). In 4 (6.67%) cases an accessory motor branch was found. The mean CSA of
      the median nerve was 0.19 cm(2). The median nerves from the right hand had a
      statistically larger CSA (p = 0.017). The number of nerve bundles in the median
      nerve varied between 13 to 38 and in the motor branch of the median nerve between
      4 to 14. CONCLUSIONS: The nerve bundles of the median nerve, at the level of the 
      carpal tunnel, display no particular type of arrangement. ImageJ software proved 
      useful in the assessment of the histological structure of the human median nerve 
      and its motor branch.
FAU - Mizia, E
AU  - Mizia E
AD  - Department of Anatomy, Jagiellonian University Medical College, Krakow, Poland.
FAU - Tomaszewski, K A
AU  - Tomaszewski KA
FAU - Lis, G J
AU  - Lis GJ
FAU - Goncerz, G
AU  - Goncerz G
FAU - Kurzydlo, W
AU  - Kurzydlo W
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - Folia Morphol (Warsz)
JT  - Folia morphologica
JID - 0374620
SB  - IM
MH  - Cadaver
MH  - Carpal Bones/anatomy & histology
MH  - Female
MH  - Humans
MH  - *Image Processing, Computer-Assisted
MH  - Male
MH  - Median Nerve/*anatomy & histology
MH  - Nerve Fibers
EDAT- 2012/06/01 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/06/01 06:00
PHST- 2012/06/01 06:00 [entrez]
PHST- 2012/06/01 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
PST - ppublish
SO  - Folia Morphol (Warsz). 2012 May;71(2):82-5.


PMID- 22648539
OWN - NLM
STAT- MEDLINE
DCOM- 20120921
LR  - 20170201
IS  - 1699-5848 (Electronic)
IS  - 0213-3911 (Linking)
VI  - 27
IP  - 7
DP  - 2012 Jul
TI  - Identification, characterization and biological significance of very small
      embryonic-like stem cells (VSELs) in regenerative medicine.
PG  - 827-33
LID - 10.14670/HH-27.827 [doi]
AB  - The progress of stem cell research, along with technological innovation, has
      brought researchers to focus on the potential role of stem cells in regenerative 
      medicine. Ethical and technological issues have limited the applications of human
      embryonic stem cells (hESCs) in this field. As a promising candidate, very small 
      embryonic-like stem cells (VSELs) express a multitude of pluripotent stem cell
      markers and demonstrate the ability to differentiate into three germ-layer
      lineages in vitro. Optimized methods for isolation and expansion of VSELs have
      aroused the scientific community's interest in use of this kind of cells for
      regenerative purposes. In this review, we will focus on the biological
      characteristics, as well as the potentiality and remaining challenges in clinical
      application of VSELs. Moreover, a comparison among VSELs and the other
      pluripotent stem cells will be illustrated to highlight the unique advantages of 
      VSELs.
FAU - Feng, Guowei
AU  - Feng G
AD  - Department of Pathophysiology, Nankai University School of Medicine, Tianjin,
      China.
FAU - Cui, Jian
AU  - Cui J
FAU - Zheng, Yizhou
AU  - Zheng Y
FAU - Han, Zhongchao
AU  - Han Z
FAU - Xu, Yong
AU  - Xu Y
FAU - Li, Zongjin
AU  - Li Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Spain
TA  - Histol Histopathol
JT  - Histology and histopathology
JID - 8609357
SB  - IM
MH  - Adult Stem Cells/*cytology/*physiology
MH  - Animals
MH  - Embryonic Stem Cells/cytology/physiology
MH  - Humans
MH  - Pluripotent Stem Cells/*cytology/*physiology
MH  - Regenerative Medicine/*methods
EDAT- 2012/06/01 06:00
MHDA- 2012/09/22 06:00
CRDT- 2012/06/01 06:00
PHST- 2012/06/01 06:00 [entrez]
PHST- 2012/06/01 06:00 [pubmed]
PHST- 2012/09/22 06:00 [medline]
AID - 10.14670/HH-27.827 [doi]
PST - ppublish
SO  - Histol Histopathol. 2012 Jul;27(7):827-33. doi: 10.14670/HH-27.827.


PMID- 22648445
OWN - NLM
STAT- MEDLINE
DCOM- 20130207
LR  - 20120912
IS  - 1432-0711 (Electronic)
IS  - 0932-0067 (Linking)
VI  - 286
IP  - 4
DP  - 2012 Oct
TI  - Anterior colporrhaphy versus repair with mesh for anterior vaginal wall prolapse:
      a comparative clinical study.
PG  - 965-72
LID - 10.1007/s00404-012-2383-6 [doi]
AB  - PURPOSE: To compare the clinical effectiveness of anterior colporrhaphy versus
      mesh repair as surgical management of anterior vaginal prolapse. METHODS: Of 50
      patients with >/=stage II anterior vaginal prolapse on Pelvic Organ Prolapse
      Quantification (POPQ) system who were initially approached, 44 consented and
      underwent surgery. They were randomly recruited into two groups. Group I (23
      patients) received anterior colporrhaphy, while group II (21 patients) received
      soft polypropylene mesh (GYNEMESH*PS, Gynecare, Ethicon, France). Clinical
      assessment took place preoperatively and postoperatively at definite intervals.
      Functional and anatomical comparisons were based on comparison between
      preoperative and 24 months postoperative assessments of symptoms and POPQ stages,
      respectively. Four patients in total did not complete the follow-up assessments
      and were excluded. RESULTS: Both groups showed clinical improvement in their
      symptoms and POPQ staging at the end of the postoperative follow-up period.
      Improvement, however, was more significant in the repair with mesh group, as
      patients in this group reported better improvement of their prolapse symptoms,
      mainly vaginal bulge/pressure sensation (P < 0.05), and showed better improvement
      in the anatomical staging, individual POP-Q points Aa and Ba (P < 0.01), than the
      anterior colporrhaphy group. Group II also showed more satisfactory outcome with 
      the general POP-Q staging (P < 0.05) than group I, reflecting a better quality of
      life of the patients in the repair with mesh group. CONCLUSION: Our data shows
      that repair with mesh is superior to anterior colporrhaphy with more satisfactory
      outcome to the patients. Due to the small size of our study and uncertainty of
      the long-term safety and resilience of the mesh, we recommend larger studies to
      confirm our preliminary results.
FAU - El-Nazer, M A
AU  - El-Nazer MA
AD  - Department of Obstetrics and Gynecology, Ain Shams University, Cairo, Egypt.
FAU - Gomaa, I A
AU  - Gomaa IA
FAU - Ismail Madkour, W A
AU  - Ismail Madkour WA
FAU - Swidan, K H
AU  - Swidan KH
FAU - El-Etriby, M A
AU  - El-Etriby MA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20120531
PL  - Germany
TA  - Arch Gynecol Obstet
JT  - Archives of gynecology and obstetrics
JID - 8710213
SB  - IM
MH  - Adult
MH  - Female
MH  - *Gynecologic Surgical Procedures
MH  - Humans
MH  - Middle Aged
MH  - Surgical Mesh
MH  - Treatment Outcome
MH  - Uterine Prolapse/*surgery
EDAT- 2012/06/01 06:00
MHDA- 2013/02/08 06:00
CRDT- 2012/06/01 06:00
PHST- 2012/01/28 00:00 [received]
PHST- 2012/05/08 00:00 [accepted]
PHST- 2012/06/01 06:00 [entrez]
PHST- 2012/06/01 06:00 [pubmed]
PHST- 2013/02/08 06:00 [medline]
AID - 10.1007/s00404-012-2383-6 [doi]
PST - ppublish
SO  - Arch Gynecol Obstet. 2012 Oct;286(4):965-72. doi: 10.1007/s00404-012-2383-6. Epub
      2012 May 31.


PMID- 22647926
OWN - NLM
STAT- MEDLINE
DCOM- 20130128
LR  - 20120723
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 8
DP  - 2012 Aug
TI  - Gift-giving in the medical student--patient relationship.
PG  - 506-7
LID - 10.1136/medethics-2012-100738 [doi]
AB  - There is paucity in the published literature that provides any ethical guidance
      guiding gift-giving within the student--patient relationship. This is perhaps
      because the dynamics of the medical student--patient relationship have not yet
      been explored as extensively as the doctor--patient relationship. More
      importantly, however, gift--giving in the doctor-patient relationship has
      traditionally been from the patient to the doctor and not vice versa. This
      article examines the literature published in this vicinity reflecting on an
      encounter with a patient.
FAU - Alamri, Yassar Abdullah S
AU  - Alamri YA
AD  - New Zealand Brain Research Institute, 66 Stewart Street, Central Christchurch,
      Christchurch 8011, New Zealand. yasao@hotmail.com
LA  - eng
PT  - Journal Article
DEP - 20120530
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Ethics, Medical
MH  - Gift Giving/*ethics
MH  - Humans
MH  - New Zealand
MH  - Physician-Patient Relations/*ethics
MH  - *Students, Medical
EDAT- 2012/06/01 06:00
MHDA- 2013/01/29 06:00
CRDT- 2012/06/01 06:00
PHST- 2012/06/01 06:00 [entrez]
PHST- 2012/06/01 06:00 [pubmed]
PHST- 2013/01/29 06:00 [medline]
AID - medethics-2012-100738 [pii]
AID - 10.1136/medethics-2012-100738 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Aug;38(8):506-7. doi: 10.1136/medethics-2012-100738. Epub 2012
      May 30.


PMID- 29776254
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1744-828X (Electronic)
IS  - 1741-0541 (Linking)
VI  - 9
IP  - 4
DP  - 2012 Jun
TI  - Conference Scene: Personalized medicine: changing the healthcare paradigm.
PG  - 367-370
LID - 10.2217/pme.12.39 [doi]
AB  - The US Air Force Patient-Centered Precision Care Genomic Medicine Research
      Program hosted a symposium entitled 'Changing the Health Care Paradigm' on 27
      September 2011 in Laurel, MD, USA. The program provided a unique opportunity for 
      subject matter experts to participate in critical discussions on the current and 
      potential outlook for the implementation of genome-informed healthcare. The
      implications for patient privacy, data management and security revealed the
      ethical, legal and social issues faced by clinicians, patients and policy-makers.
      Highlights from these discussions are summarized in this article.
FAU - Carruth, Lucy M
AU  - Carruth LM
AD  - Johns Hopkins University Applied Physics Laboratory, 11100 Johns Hopkins Road,
      Laurel, MD 20723, USA. lucy.carruth@jhuapl.edu.
FAU - Vogel, Ruth A
AU  - Vogel RA
AD  - Johns Hopkins University Applied Physics Laboratory, 11100 Johns Hopkins Road,
      Laurel, MD 20723, USA.
FAU - Sessions, Cecili K
AU  - Sessions CK
AD  - US Air Force Medical Service Medical Innovations Division (SG9Z), Office of the
      Air Force Surgeon General, 5201 Leesburg Pike, Suite 1012, Falls Church, VA
      22041, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Per Med
JT  - Personalized medicine
JID - 101238549
EDAT- 2012/06/01 00:00
MHDA- 2012/06/01 00:01
CRDT- 2018/05/20 06:00
PHST- 2018/05/20 06:00 [entrez]
PHST- 2012/06/01 00:00 [pubmed]
PHST- 2012/06/01 00:01 [medline]
AID - 10.2217/pme.12.39 [doi]
PST - ppublish
SO  - Per Med. 2012 Jun;9(4):367-370. doi: 10.2217/pme.12.39.


PMID- 29443317
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2163-0402 (Print)
IS  - 2163-0402 (Linking)
VI  - 2
IP  - 2
DP  - 2012 Jun
TI  - Medical decisions are not just about the facts: What a life-threatening virus can
      teach us about empathy, psychology, and the practice of neurology.
PG  - 122-128
LID - 10.1212/CPJ.0b013e31825a7848 [doi]
AB  - Getting the facts about risk and benefit is a critical part of medical
      decision-making. But when doctors and patients disagree on what is reasonable
      risk, it takes more than a grasp of the data to establish the way forward. Our
      competence as physician-scientists relies on our ability to master the mechanics 
      and information flow of our specialty. But we physicians, curious amalgams of
      scientists, scholars, researchers, and healers, should be aware of how we respond
      to the uniqueness of each of our physician-patient relationships, and be willing 
      to explore ways in which the psychological and interpersonal dynamics influence
      the ethical, medically correct choices we pursue in them.
FAU - Kachuck, Norman J
AU  - Kachuck NJ
AD  - Department of Neurology, USC Keck School of Medicine, Los Angeles, CA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Neurol Clin Pract
JT  - Neurology. Clinical practice
JID - 101577149
PMC - PMC5798207
EDAT- 2012/06/01 00:00
MHDA- 2012/06/01 00:01
CRDT- 2018/02/15 06:00
PHST- 2018/02/15 06:00 [entrez]
PHST- 2012/06/01 00:00 [pubmed]
PHST- 2012/06/01 00:01 [medline]
AID - 10.1212/CPJ.0b013e31825a7848 [doi]
AID - 1586158-201206000-00006 [pii]
PST - ppublish
SO  - Neurol Clin Pract. 2012 Jun;2(2):122-128. doi: 10.1212/CPJ.0b013e31825a7848.


PMID- 28517419
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 2473-4209 (Electronic)
IS  - 0094-2405 (Linking)
VI  - 39
IP  - 6Part3
DP  - 2012 Jun
TI  - SU-E-E-03: Ethics and Professionalism Education in Medical Physics: A Needs
      Assessment Study.
PG  - 3623-3624
LID - 10.1118/1.4734712 [doi]
AB  - PURPOSE: To perform a needs assessment survey of ethics/professionalism education
      in medical physics and ethical/professional challenges in clinical,research and
      educational settings with the intent of supplementing and customizing TG159
      recommended ethics curriculum for medical physics trainees. METHODS: A web-based 
      survey was conducted among AAPM members to assess current practices, attitudes
      and perceptions pertaining to ethics/professionalism education and
      ethical/professional misconduct or questionable behavior and practices in the
      field. RESULTS: The survey was distributed by AAPM to 7708 members via email;
      1362 (17.7%) responded. Seventy-five percent of the respondents were male. Sixty 
      percent (805/1345) stated they received no education in ethics/professionalism.
      Eighty-one percent (126/155) of current trainees received instruction in
      ethics/professionalism, as opposed to 35% (392/1130) of those who are
      post-training. There was strong support (>90%) for continuing education in
      ethics/professionalism; seventy-five percent (1019/1354) supported sessions on
      ethics and professionalism at national meetings. Most preferred method of ethics 
      instruction was periodic discussion sessions involving faculty and trainees, with
      the least interest expressed for a separate course. Many reported direct personal
      knowledge of one or more instances of a variety of professional/ethical
      misconduct or questionable behavior. Thirty eight percent (458/1192) reported
      poor mentorship, with women reporting this concern more often than men
      (129/281,46% versus 316/877, 36%, p<.05). Over one-fourth of respondents reported
      being asked to perform low educational value tasks and expressed concerns about
      fairness. A significant minority also reported questionable behavior with respect
      to authorship assignment (346/920, 38%), data fabrication (107/924, 12%), data
      falsification (94/919, 10%); concerns about research subject privacy and
      confidentiality were lower (64/887, 7%). CONCLUSIONS: Data gathered through the
      survey is guiding our efforts to develop a case-based ethics curriculum and
      instructional materials for medical physics trainees at our institution. This
      effort may be useful to other medical physics programs which offer ethics
      training/education. This work has been funded in part by a grant from the
      National Institutes of Health, T32 EB002103-22S1.
CI  - (c) 2012 American Association of Physicists in Medicine.
FAU - Ozturk, N
AU  - Ozturk N
AD  - The University of Chicago, Chicago, IL.
AD  - Mayo Clinic, Jacksonville, FL.
FAU - Armato, S
AU  - Armato S
AD  - The University of Chicago, Chicago, IL.
AD  - Mayo Clinic, Jacksonville, FL.
FAU - Giger, M L
AU  - Giger ML
AD  - The University of Chicago, Chicago, IL.
AD  - Mayo Clinic, Jacksonville, FL.
FAU - Serago, C
AU  - Serago C
AD  - The University of Chicago, Chicago, IL.
AD  - Mayo Clinic, Jacksonville, FL.
FAU - Ross, L F
AU  - Ross LF
AD  - The University of Chicago, Chicago, IL.
AD  - Mayo Clinic, Jacksonville, FL.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Phys
JT  - Medical physics
JID - 0425746
OTO - NOTNLM
OT  - Medical physics
OT  - Physics education
EDAT- 2012/06/01 00:00
MHDA- 2012/06/01 00:01
CRDT- 2017/05/19 06:00
PHST- 2017/05/19 06:00 [entrez]
PHST- 2012/06/01 00:00 [pubmed]
PHST- 2012/06/01 00:01 [medline]
AID - 10.1118/1.4734712 [doi]
PST - ppublish
SO  - Med Phys. 2012 Jun;39(6Part3):3623-3624. doi: 10.1118/1.4734712.


PMID- 28479876
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1608-9693 (Print)
IS  - 1608-9693 (Linking)
VI  - 13
IP  - 2
DP  - 2012 Jun
TI  - A review of the use of blood and blood products in HIV-infected patients.
PG  - 87-104
AB  - Despite numerous publications on the appropriate use of blood and blood products,
      few specifically consider the role of transfusion in the management of HIV. This 
      review is a synthesis of conditions encountered in the management of HIV-infected
      patients where the transfusion of blood or blood products may be indicated. A
      consistent message emerging from the review is that the principles of transfusion
      medicine do not differ between HIV-negative and -positive patients. The aim of
      the review is to provide clinicians with a practical and succinct overview of the
      haematological abnormalities and clinical circumstances most commonly encountered
      in the HIV setting, while focusing on the rational and appropriate use of blood
      and blood products for HIV patients. Important ethical considerations in dealing 
      with both the collection and transfusion blood and blood products in the HIV era 
      have also been addressed.
FAU - van den Berg, Karin
AU  - van den Berg K
FAU - van Hasselt, James
AU  - van Hasselt J
FAU - Bloch, Evan
AU  - Bloch E
FAU - Crookes, Robert
AU  - Crookes R
FAU - Kelley, James
AU  - Kelley J
FAU - Berger, Jonathan
AU  - Berger J
FAU - Ingram, Charlotte
AU  - Ingram C
FAU - Dippenaar, Anel
AU  - Dippenaar A
FAU - Thejpal, Rajendra
AU  - Thejpal R
FAU - Littleton, Neil
AU  - Littleton N
FAU - Elliz, Tersia
AU  - Elliz T
FAU - Reubenson, Gary
AU  - Reubenson G
FAU - Cotton, Mark
AU  - Cotton M
FAU - Hull, Jennifer C
AU  - Hull JC
FAU - Moodley, Pamela
AU  - Moodley P
FAU - Goga, Yasmin
AU  - Goga Y
FAU - Eldridge, William
AU  - Eldridge W
FAU - Patel, Moosa
AU  - Patel M
FAU - Hefer, Eric
AU  - Hefer E
FAU - Bird, Arthur
AU  - Bird A
LA  - eng
GR  - K24 HL075036/HL/NHLBI NIH HHS/United States
PT  - Journal Article
DEP - 20120607
PL  - South Africa
TA  - South Afr J HIV Med
JT  - Southern African journal of HIV medicine
JID - 100965417
PMC - PMC5419681
MID - NIHMS819378
EDAT- 2012/06/01 00:00
MHDA- 2012/06/01 00:01
CRDT- 2017/05/09 06:00
PHST- 2017/05/09 06:00 [entrez]
PHST- 2012/06/01 00:00 [pubmed]
PHST- 2012/06/01 00:01 [medline]
AID - 10.4102/sajhivmed.v13i2.146 [doi]
PST - ppublish
SO  - South Afr J HIV Med. 2012 Jun;13(2):87-104. doi: 10.4102/sajhivmed.v13i2.146.
      Epub 2012 Jun 7.


PMID- 26767358
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160116
LR  - 20160115
IS  - 1758-5864 (Print)
IS  - 1758-5864 (Linking)
VI  - 4
IP  - 2
DP  - 2012 Jun
TI  - Ethical issues in researching interventions for behavioral disturbance in
      psychotic disorders.
PG  - 140-3
LID - 10.1111/j.1758-5872.2012.00178.x [doi]
FAU - Chan, Esther W
AU  - Chan EW
AD  - Department of Pharmacy Practice, Centre for Medicine Use and Safety, Monash
      University, Melbourne, Victoria, Australia.
FAU - Kong, David C M
AU  - Kong DC
AD  - Department of Pharmacy Practice, Centre for Medicine Use and Safety, Monash
      University, Melbourne, Victoria, Australia.
FAU - Knott, Jonathan C
AU  - Knott JC
AD  - Emergency Department, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
FAU - Castle, David J
AU  - Castle DJ
AD  - Department of Psychiatry, St. Vincent's Hospital, Melbourne, Victoria, Australia.
AD  - Department of Psychiatry, The University of Melbourne, Melbourne, Victoria,
      Australia.
LA  - eng
PT  - Journal Article
DEP - 20120411
PL  - Australia
TA  - Asia Pac Psychiatry
JT  - Asia-Pacific psychiatry : official journal of the Pacific Rim College of
      Psychiatrists
JID - 101506757
EDAT- 2012/06/01 00:00
MHDA- 2012/06/01 00:01
CRDT- 2016/01/16 06:00
PHST- 2011/09/27 00:00 [received]
PHST- 2011/12/01 00:00 [accepted]
PHST- 2016/01/16 06:00 [entrez]
PHST- 2012/06/01 00:00 [pubmed]
PHST- 2012/06/01 00:01 [medline]
AID - 10.1111/j.1758-5872.2012.00178.x [doi]
PST - ppublish
SO  - Asia Pac Psychiatry. 2012 Jun;4(2):140-3. doi: 10.1111/j.1758-5872.2012.00178.x. 
      Epub 2012 Apr 11.


PMID- 26573507
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151124
LR  - 20151117
IS  - 0034-7450 (Print)
IS  - 0034-7450 (Linking)
VI  - 41
IP  - 2
DP  - 2012 Jun
TI  - [Shared Psychotic Disorder between Two Sisters].
PG  - 444-55
LID - 10.1016/S0034-7450(14)60018-4 [doi]
LID - S0034-7450(14)60018-4 [pii]
AB  - INTRODUCTION: The Shared Psychotic Disorder, also known as "folie a deux", is a
      mental disorder characterized by the development of psychiatric symptoms
      (psychotic symptoms) in an individual within the context of a close interpersonal
      relationship with another individual who has an established mental illness,
      usually with the presence of delusions. It is not considered a common disorder,
      its diagnosis is rare and it is a condition in which psychosocial factors are
      vital for its development. OBJECTIVE: To present the case of two sisters, the
      social consequences and difficulties in the intervention as well as ethical
      issues related to involuntary hospitalization. To perform a brief review of the
      topic so as to have a framework for the case. METHOD: Case report. CONCLUSIONS:
      This case makes evident the difficulty to achieve an adequate pharmacological and
      psychotherapeutic intervention because delusion symptoms can affect not only one 
      but several family members. Furthermore, this case accounts both for individual
      risks inherent to the disease and for social risks involving third parties.
CI  - Copyright (c) 2012 Asociacion Colombiana de Psiquiatria. Publicado por Elsevier
      Espana. All rights reserved.
FAU - Torres, Carolina Rodriguez
AU  - Torres CR
AD  - Medica psiquiatra, Pontificia Universidad Javeriana. Hospital Santa Clara.
      Bogota, Colombia. Electronic address: carorodriguez10@hotmail.com.
FAU - Yasno, Marcelo Andres Hernandez
AU  - Yasno MA
AD  - Medico(a) psiquiatra, Universidad Nacional de Colombia. Hospital Santa Clara.
      Bogota, Colombia.
FAU - Morales, Martha Constanza Rangel
AU  - Morales MC
AD  - Medico(a) psiquiatra, Universidad Nacional de Colombia. Hospital Santa Clara.
      Bogota, Colombia.
FAU - Gutierrez, Angela Maria Martinez
AU  - Gutierrez AM
AD  - Medica psiquiatra, Universidad El Bosque. Hospital Santa Clara. Bogota, Colombia.
FAU - Varela, Yaneth Valero
AU  - Varela YV
AD  - Trabajadora social, Colegio Mayor de Cundinamarca. Universidad Santo Tomas.
      Hospital Santa Clara. Bogota, Colombia.
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Trastorno psicotico compartido: a proposito de un caso entre dos hermanas.
DEP - 20140510
PL  - Colombia
TA  - Rev Colomb Psiquiatr
JT  - Revista colombiana de psiquiatria
JID - 0045130
EDAT- 2012/06/01 00:00
MHDA- 2012/06/01 00:01
CRDT- 2015/11/18 06:00
PHST- 2011/11/10 00:00 [received]
PHST- 2012/04/08 00:00 [accepted]
PHST- 2015/11/18 06:00 [entrez]
PHST- 2012/06/01 00:00 [pubmed]
PHST- 2012/06/01 00:01 [medline]
AID - S0034-7450(14)60018-4 [pii]
AID - 10.1016/S0034-7450(14)60018-4 [doi]
PST - ppublish
SO  - Rev Colomb Psiquiatr. 2012 Jun;41(2):444-55. doi: 10.1016/S0034-7450(14)60018-4. 
      Epub 2014 May 10.


PMID- 26573502
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151124
LR  - 20151117
IS  - 0034-7450 (Print)
IS  - 0034-7450 (Linking)
VI  - 41
IP  - 2
DP  - 2012 Jun
TI  - [From the Principle of Beneficence to the Principle of Autonomy. Assessment of
      Patients' Mental Competency in the General Hospital].
PG  - 395-407
LID - 10.1016/S0034-7450(14)60013-5 [doi]
LID - S0034-7450(14)60013-5 [pii]
AB  - INTRODUCTION: Refusing a medical procedure is a valid way of exercising every
      patient's right to autonomy. From the legal point of view, autonomy is based on
      the right to privacy. In recent decades the legal right to self-determination has
      gradually expanded and today patients in full possession of their mental
      faculties, have the moral and legal right to make their own decisions and these
      decisions take precedence over physician and family. Often liaison psychiatrists 
      are called in to assess the mental competence of patients in the general
      hospital. OBJECTIVE: To determine the psychiatrist's role in evaluating these
      patients. DISCUSSION AND CONCLUSIONS: The assessment of a patient's ability to
      decide and self-determine is a common clinical problem in general hospitals.
      Evaluation of these patients requires a proper understanding of the
      philosophical, ethical, and legal issues that guide the appropriate treatment of 
      these complex clinical problems.
CI  - Copyright (c) 2012 Asociacion Colombiana de Psiquiatria. Publicado por Elsevier
      Espana. All rights reserved.
FAU - Diana, Restrepo B
AU  - Diana RB
AD  - Medica(o) psiquiatra de Enlace, Hospital Universitario San Vicente Fundacion,
      Medellin, Colombia. Electronic address: dianarestrepobernal@gmail.com.
FAU - Carlos, Cardeno C
AU  - Carlos CC
AD  - Medica(o) psiquiatra de Enlace, Hospital Universitario San Vicente Fundacion,
      Medellin, Colombia.
FAU - Marle, Duque G
AU  - Marle DG
AD  - Medico residente de Psiquiatria de III ano, Universidad de Antioquia, Medellin,
      Colombia.
FAU - Santiago, Jaramillo
AU  - Santiago J
AD  - Medico psiquiatra, Universidad de Antioquia, Medellin, Colombia.
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Del principio de beneficencia al principio de autonomia: aproximacion a la
      evaluacion de la competencia mental de los pacientes en el hospital general.
DEP - 20140510
PL  - Colombia
TA  - Rev Colomb Psiquiatr
JT  - Revista colombiana de psiquiatria
JID - 0045130
OTO - NOTNLM
OT  - Capacidad para decidir
OT  - Capacity to decide
OT  - autonomy
OT  - autonomia
OT  - consentimiento informado
OT  - informed consent
OT  - liaison psychiatry
OT  - psiquiatria de enlace
EDAT- 2012/06/01 00:00
MHDA- 2012/06/01 00:01
CRDT- 2015/11/18 06:00
PHST- 2012/01/28 00:00 [received]
PHST- 2012/05/02 00:00 [accepted]
PHST- 2015/11/18 06:00 [entrez]
PHST- 2012/06/01 00:00 [pubmed]
PHST- 2012/06/01 00:01 [medline]
AID - S0034-7450(14)60013-5 [pii]
AID - 10.1016/S0034-7450(14)60013-5 [doi]
PST - ppublish
SO  - Rev Colomb Psiquiatr. 2012 Jun;41(2):395-407. doi: 10.1016/S0034-7450(14)60013-5.
      Epub 2014 May 10.


PMID- 25812985
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150328
LR  - 20220214
IS  - 2005-727X (Print)
IS  - 2005-727X (Linking)
VI  - 24
IP  - 2
DP  - 2012 Jun
TI  - Experience of developing and implementing a motivation induction course for
      konyang university medical college freshmen.
PG  - 141-52
LID - 10.3946/kjme.2012.24.2.141 [doi]
AB  - PURPOSE: This study aimed to develop a new course for Konyang University College 
      of Medicine freshmen to motivate them with regard to their vision and medical
      professionalism and experience various learning methods of medical education.
      METHODS: The course was developed by 4 faculty members through several intensive 
      meetings throughout the winter of 2010. A 4-credit course was designed for 61
      freshmen of Konyang University College of Medicine to provide structured guidance
      and an introduction to their medical education and increase their motivation with
      regard to their studies and school life. The course lasted for 4 weeks (February 
      28 to March 25), and every session of the program was evaluated by the students. 
      RESULTS: The 'motivation induction course' consisted of the following sessions:
      university-wide: 'leadership camp' and 'special lectures for future vision;'
      college-wide: 'major immersion session,' 'Enneagram workshop,' 'STRONG workshop,'
      'medical professionalism,' and 'team-based learning.' The group results were
      presented in a poster and by oral presentation and were awarded prizes for the
      best performance. Special features included: group discussion session on medical 
      ethics, which used scenarios that were developed by a medical humanity course
      committee and visiting all departments and mentors of the medical college to
      fulfill their curiosity of their future major or workplace. Overall, the course
      was evaluated as satisfactory (M=4.22, SD=0.81). CONCLUSION: Although there was
      some dissatisfaction, the overall experience of the "motivation induction course"
      was a success. The course will continue to be valuable for freshmen in adapting
      to medical school and its culture and in defining one's view of a good doctor.
FAU - Na, Beag Ju
AU  - Na BJ
AD  - Department of Medical Education, Konyang University College of Medicine, Daejeon,
      Korea.
FAU - Lee, Keumho
AU  - Lee K
AD  - Department of Medical Education, Konyang University College of Medicine, Daejeon,
      Korea.
FAU - Kim, Kunil
AU  - Kim K
AD  - Department of Medicine, Konyang University College of Medicine, Daejeon, Korea.
FAU - Song, Daun
AU  - Song D
AD  - Department of Medicine, Konyang University College of Medicine, Daejeon, Korea.
FAU - Hur, Yera
AU  - Hur Y
AD  - Department of Medical Education, Konyang University College of Medicine, Daejeon,
      Korea.
LA  - eng
PT  - Journal Article
DEP - 20120630
PL  - Korea (South)
TA  - Korean J Med Educ
JT  - Korean journal of medical education
JID - 101503071
PMC - PMC8813382
OTO - NOTNLM
OT  - Curriculum development
OT  - Medical student
OT  - Motivation
EDAT- 2012/06/01 00:00
MHDA- 2012/06/01 00:01
CRDT- 2015/03/28 06:00
PHST- 2012/01/09 00:00 [received]
PHST- 2012/02/21 00:00 [accepted]
PHST- 2015/03/28 06:00 [entrez]
PHST- 2012/06/01 00:00 [pubmed]
PHST- 2012/06/01 00:01 [medline]
AID - kjme.2012.24.2.141 [pii]
AID - 10.3946/kjme.2012.24.2.141 [doi]
PST - ppublish
SO  - Korean J Med Educ. 2012 Jun;24(2):141-52. doi: 10.3946/kjme.2012.24.2.141. Epub
      2012 Jun 30.


PMID- 24654044
OWN - NLM
STAT- MEDLINE
DCOM- 20150521
LR  - 20140321
IS  - 2045-4368 (Electronic)
IS  - 2045-435X (Linking)
VI  - 2
IP  - 2
DP  - 2012 Jun
TI  - Ethical issues: invasive ventilation in amyotrophic lateral sclerosis.
PG  - 85-6
LID - 10.1136/bmjspcare-2012-000195 [doi]
FAU - Spataro, Rossella
AU  - Spataro R
AD  - Department of Neurosciences and Experimental Biomedicine, ALS Clinical Research
      Center, University of Palermo, Palermo, Italy.
FAU - La Bella, Vincenzo
AU  - La Bella V
LA  - eng
PT  - Letter
DEP - 20120417
PL  - England
TA  - BMJ Support Palliat Care
JT  - BMJ supportive & palliative care
JID - 101565123
SB  - IM
MH  - Amyotrophic Lateral Sclerosis/psychology/*therapy
MH  - Humans
MH  - Respiration, Artificial/*ethics
MH  - Tracheostomy
EDAT- 2012/06/01 00:00
MHDA- 2015/05/23 06:00
CRDT- 2014/03/22 06:00
PHST- 2014/03/22 06:00 [entrez]
PHST- 2012/06/01 00:00 [pubmed]
PHST- 2015/05/23 06:00 [medline]
AID - bmjspcare-2012-000195 [pii]
AID - 10.1136/bmjspcare-2012-000195 [doi]
PST - ppublish
SO  - BMJ Support Palliat Care. 2012 Jun;2(2):85-6. doi: 10.1136/bmjspcare-2012-000195.
      Epub 2012 Apr 17.


PMID- 24482556
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 0717-5906 (Print)
IS  - 0717-5906 (Linking)
VI  - 18
IP  - 1
DP  - 2012 Jun 1
TI  - [Experiences and impact of an ethics of research training.]
PG  - 77-81
AB  - This article has the purpose to describe achievements and impact of the ethics of
      research training at the Interdisciplinary Center for Studies on Bioethics of the
      University of Chile, which has served as incentive, motivation and guide for
      professionals which require knowledge, regulations application and dialogue
      skills to reflect on problems of this discipline. Furthermore, it describes how
      this knowledge generates a multiplying effect in aspects such as participation in
      scientific ethical review committees, course organization and the creation and
      development of research lines, which generate publications by post degree
      students. It also narrates didactic contents and strategies which could be
      applied in ethics and bioethics courses for oral health students and concludes
      mentioning practical applications of this training for teaching, research and
      institutional development.
FAU - Rupaya, Carmen Rosa Garcia
AU  - Rupaya CR
AD  - Cirujano-Dentista UNFV, Peru. Diplomado Internacional Etica en Investigacion
      Biomedica y Psicosocial, Egresada 2008.
LA  - spa
GR  - R25 TW006056/TW/FIC NIH HHS/United States
PT  - Journal Article
TT  - Experiencias y repercusion de una formacion en etica de investigacion.
PL  - Chile
TA  - Acta Bioeth
JT  - Acta bioethica
JID - 101259128
PMC - PMC3904861
MID - NIHMS373240
OTO - NOTNLM
OT  - ethics
OT  - oral health
OT  - research
EDAT- 2012/06/01 00:00
MHDA- 2012/06/01 00:01
CRDT- 2014/02/01 06:00
PHST- 2014/02/01 06:00 [entrez]
PHST- 2012/06/01 00:00 [pubmed]
PHST- 2012/06/01 00:01 [medline]
AID - 10.4067/S1726-569X2012000100006 [doi]
PST - ppublish
SO  - Acta Bioeth. 2012 Jun 1;18(1):77-81. doi: 10.4067/S1726-569X2012000100006.


PMID- 22644503
OWN - NLM
STAT- MEDLINE
DCOM- 20130429
LR  - 20140325
IS  - 1572-8633 (Electronic)
IS  - 1386-7423 (Linking)
VI  - 15
IP  - 4
DP  - 2012 Nov
TI  - Analysis and critical review of the development of bioethics in Belarus.
PG  - 365-71
LID - 10.1007/s11019-012-9415-7 [doi]
AB  - The main trends of the bioethics development in Belarus have been analyzed on the
      basis of the materials collected by the Ethics Documentation Center (ISEU, Minsk,
      Belarus). A critical review of the most important publications in the field since
      2000 suggests that development of bioethics in Belarus has occurred in two
      parallel directions distantly connected to each other: a theoretical direction
      and a practical one. Despite there are objective and subjective reasons for
      introducing bioethics in Belarus as an institutionally-organized system based on 
      liberal values such as individual rights and freedom, a range of essential
      problems could be identified. Non-equivalent regulation of ethical issues in
      health care and other fields of biomedical research has been emphasized, as well 
      as the problem of unclear hierarchical relationships among institutions dealing
      with various aspects of bioethics in the country and low ethical and educational 
      level of the social and professional groups involved in further expansion of
      bioethical knowledge. The contextual aspects of the development of bioethics in
      the country such as the consequences of the Chernobyl disaster, the prevalence of
      the authoritarian social morality and traditionally paternalistic nature of the
      relations between physicians and their patients are discussed.
FAU - Vishneuskaya, Yuliya A
AU  - Vishneuskaya YA
AD  - Ethics Documentation Centre, International Sakharov Environmental University,
      Dolgobrodskaya Str., 23-215, 220070 Minsk, Belarus. stk71016@yandex.ru
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Med Health Care Philos
JT  - Medicine, health care, and philosophy
JID - 9815900
SB  - IM
MH  - *Bioethical Issues/legislation & jurisprudence
MH  - Bioethics/education/*trends
MH  - Biomedical Research/ethics/legislation & jurisprudence
MH  - Clinical Trials as Topic/ethics/legislation & jurisprudence
MH  - Delivery of Health Care/ethics/legislation & jurisprudence
MH  - Ethics, Medical
MH  - *Freedom
MH  - Humans
MH  - *Paternalism
MH  - Political Systems
MH  - Politics
MH  - Republic of Belarus
MH  - *Social Values
EDAT- 2012/05/31 06:00
MHDA- 2013/04/30 06:00
CRDT- 2012/05/31 06:00
PHST- 2012/05/31 06:00 [entrez]
PHST- 2012/05/31 06:00 [pubmed]
PHST- 2013/04/30 06:00 [medline]
AID - 10.1007/s11019-012-9415-7 [doi]
PST - ppublish
SO  - Med Health Care Philos. 2012 Nov;15(4):365-71. doi: 10.1007/s11019-012-9415-7.


PMID- 22644349
OWN - NLM
STAT- MEDLINE
DCOM- 20130225
LR  - 20211021
IS  - 1573-6571 (Electronic)
IS  - 0022-4197 (Linking)
VI  - 51
IP  - 3
DP  - 2012 Sep
TI  - Jewish ethical themes that should inform the national healthcare discussion: a
      prolegomenon.
PG  - 589-600
LID - 10.1007/s10943-012-9617-6 [doi]
AB  - Despite the passage of H.R. 3590 in the 111th Congress, the national healthcare
      debate in the United States continues, with repeal or modification of the Patient
      Protection and Affordable Care Act under ongoing consideration. Reference is
      often made to morality or ethics, but typically in general terms only. This paper
      elucidates themes from one system of moral theology, namely Jewish healthcare
      ethics, that would valuably inform this debate. Themes include "covenant,"
      "holiness," "justice," "mercy," "for the sake of peace," "to save a life,"
      "peoplehood," "repair of the world," "repentance," and "jubilee." Policy-related,
      economic, political, and moral challenges to acting on these principles are
      discussed.
FAU - Levin, Jeff
AU  - Levin J
AD  - Institute for Studies of Religion, Baylor University, One Bear Place #97236,
      Waco, TX 76798, USA. jeff_levin@baylor.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Relig Health
JT  - Journal of religion and health
JID - 2985199R
SB  - IM
MH  - Health Care Reform/*ethics
MH  - Humans
MH  - *Judaism
MH  - Patient Protection and Affordable Care Act/*ethics
MH  - *Policy Making
MH  - *Religion and Medicine
MH  - United States
EDAT- 2012/05/31 06:00
MHDA- 2013/02/26 06:00
CRDT- 2012/05/31 06:00
PHST- 2012/05/31 06:00 [entrez]
PHST- 2012/05/31 06:00 [pubmed]
PHST- 2013/02/26 06:00 [medline]
AID - 10.1007/s10943-012-9617-6 [doi]
PST - ppublish
SO  - J Relig Health. 2012 Sep;51(3):589-600. doi: 10.1007/s10943-012-9617-6.


PMID- 22643868
OWN - NLM
STAT- MEDLINE
DCOM- 20120926
LR  - 20211203
IS  - 1432-1440 (Electronic)
IS  - 0946-2716 (Linking)
VI  - 90
IP  - 7
DP  - 2012 Jul
TI  - Human induced pluripotent stem cells--from mechanisms to clinical applications.
PG  - 735-45
LID - 10.1007/s00109-012-0913-0 [doi]
AB  - Human pluripotent stem cells hold great promise for basic research and
      regenerative medicine due to their inherent property to propagate infinitely,
      while maintaining the potential to differentiate into any given cell type of the 
      human body. Since the first derivation in 1998, pluripotent human embryonic stem 
      cells (ESCs) have been studied intensively, and although these cells provoke
      ethical and immune rejection concerns, translation of human ESC research into the
      clinics has been initiated. The generation of embryonic stem cell-like human
      induced pluripotent stem cells (iPSCs) from somatic cells by virus-mediated
      overexpression of distinct sets of reprogramming factors (OCT4, SOX2, KLF4, and
      c-MYC, or OCT4, SOX2, NANOG, and LIN28) in 2007 has opened up further
      opportunities in the field. While circumventing the major disputes associated
      with human ESCs, iPSCs offer the same advantages and, in addition, new
      perspectives for personalized medicine. This review summarizes technical advances
      toward the generation of potentially clinically relevant human iPSCs. We also
      highlight key molecular events underlying the process of cellular reprogramming
      and discuss inherent features of iPSCs, including genome instability and
      epigenetic memory. Furthermore, we will give an overview of particular envisaged 
      human iPSC applications and point out which improvements are yet to come and what
      has been achieved so far.
FAU - Drews, Katharina
AU  - Drews K
AD  - Molecular Embryology and Aging Group, Department of Vertebrate Genomics, Max
      Planck Institute for Molecular Genetics, Ihnestr. 63-73 14195, Berlin, Germany.
FAU - Jozefczuk, Justyna
AU  - Jozefczuk J
FAU - Prigione, Alessandro
AU  - Prigione A
FAU - Adjaye, James
AU  - Adjaye J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120530
PL  - Germany
TA  - J Mol Med (Berl)
JT  - Journal of molecular medicine (Berlin, Germany)
JID - 9504370
SB  - IM
MH  - Cell Differentiation
MH  - Epigenesis, Genetic
MH  - Genomic Instability
MH  - Humans
MH  - Induced Pluripotent Stem Cells/cytology/*metabolism
MH  - Kruppel-Like Factor 4
MH  - Mitochondria/metabolism
MH  - Regenerative Medicine
MH  - Toxicity Tests
EDAT- 2012/05/31 06:00
MHDA- 2012/09/27 06:00
CRDT- 2012/05/31 06:00
PHST- 2012/03/07 00:00 [received]
PHST- 2012/05/06 00:00 [accepted]
PHST- 2012/05/03 00:00 [revised]
PHST- 2012/05/31 06:00 [entrez]
PHST- 2012/05/31 06:00 [pubmed]
PHST- 2012/09/27 06:00 [medline]
AID - 10.1007/s00109-012-0913-0 [doi]
PST - ppublish
SO  - J Mol Med (Berl). 2012 Jul;90(7):735-45. doi: 10.1007/s00109-012-0913-0. Epub
      2012 May 30.


PMID- 22643766
OWN - NLM
STAT- MEDLINE
DCOM- 20120924
LR  - 20211203
IS  - 1529-8795 (Electronic)
IS  - 0031-5982 (Linking)
VI  - 55
IP  - 2
DP  - 2012
TI  - Chinese medical ward: an American's observations.
PG  - 299-317
LID - 10.1353/pbm.2012.0014 [doi]
AB  - Physicians base their practices on scientific knowledge that varies little from
      one country to another, but their experience and their careers are shaped by the 
      culture in which they live and work. This essay casts light on medical practice
      in mainland China, based on three months of field work with an elite group of
      physicians at a tertiary academic medical center in summer 2009. It is a story of
      a diverse group of Chinese professionals navigating a demanding profession, and
      of the foreign college student on whom they left an indelible impact. Many of the
      normative features of the Chinese medical profession-its chain of command,
      commitment to medical ethics, and scientific orientation-are highly comparable to
      the working lives of American physicians.
FAU - Leonard, Ryan A
AU  - Leonard RA
AD  - Kings County Hospital Center, Office of the CEO, NewYork City Health and
      Hospitals Corporation, 451 Clarkson Avenue, Brooklyn, NY 11203, USA.
      Ryan.Leonard@nychhc.org
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Perspect Biol Med
JT  - Perspectives in biology and medicine
JID - 0401132
SB  - IM
MH  - Asians
MH  - China/ethnology
MH  - Delivery of Health Care/*ethnology/organization & administration
MH  - Ethics, Medical
MH  - Hospitals/*standards
MH  - Humans
MH  - Interprofessional Relations
MH  - Physician-Patient Relations
MH  - Practice Patterns, Physicians'/*organization & administration
MH  - Students, Medical/psychology
MH  - United States
EDAT- 2012/05/31 06:00
MHDA- 2012/09/25 06:00
CRDT- 2012/05/31 06:00
PHST- 2012/05/31 06:00 [entrez]
PHST- 2012/05/31 06:00 [pubmed]
PHST- 2012/09/25 06:00 [medline]
AID - S1529879512200122 [pii]
AID - 10.1353/pbm.2012.0014 [doi]
PST - ppublish
SO  - Perspect Biol Med. 2012;55(2):299-317. doi: 10.1353/pbm.2012.0014.


PMID- 22643759
OWN - NLM
STAT- MEDLINE
DCOM- 20120924
LR  - 20150813
IS  - 1529-8795 (Electronic)
IS  - 0031-5982 (Linking)
VI  - 55
IP  - 2
DP  - 2012
TI  - Homage to Henry Beecher (1904-1976).
PG  - 218-29
LID - 10.1353/pbm.2012.0013 [doi]
AB  - The writings of Henry Beecher (1904-1976) have had an enormous influence on
      thinking and practice with respect to the ethics of medicine and clinical
      research. This essay examines the seminal contributions of Beecher as illustrated
      by four landmark articles concerning the ethics of clinical research, the placebo
      effect and placebo-controlled trials, the evaluation of invasive procedures, and 
      "brain death" and vital organ transplantation. To appreciate Beecher's legacy, it
      is salutary to explicate the significance of his enduring contributions and to
      critically evaluate their limitations.
FAU - Miller, Franklin G
AU  - Miller FG
AD  - Department of Bioethics, Clinical Center, National Institutes of Health, Building
      10, Room 1C118, Bethesda, MD 20892-1156, USA. fmiller@nih.gov
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Biography
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PL  - United States
TA  - Perspect Biol Med
JT  - Perspectives in biology and medicine
JID - 0401132
SB  - IM
MH  - Brain Death/pathology
MH  - Clinical Trials as Topic
MH  - Ethics, Clinical/*history
MH  - History, 20th Century
MH  - Human Experimentation/ethics
MH  - Organ Transplantation/ethics
MH  - Placebo Effect
PS  - Beecher H
FPS - Beecher, Henry
EDAT- 2012/05/31 06:00
MHDA- 2012/09/25 06:00
CRDT- 2012/05/31 06:00
PHST- 2012/05/31 06:00 [entrez]
PHST- 2012/05/31 06:00 [pubmed]
PHST- 2012/09/25 06:00 [medline]
AID - S1529879512200055 [pii]
AID - 10.1353/pbm.2012.0013 [doi]
PST - ppublish
SO  - Perspect Biol Med. 2012;55(2):218-29. doi: 10.1353/pbm.2012.0013.


PMID- 22643722
OWN - NLM
STAT- MEDLINE
DCOM- 20120924
LR  - 20181201
IS  - 1529-8795 (Electronic)
IS  - 0031-5982 (Linking)
VI  - 55
IP  - 1
DP  - 2012 Winter
TI  - Group-based and personalized care in an age of genomic and evidence-based
      medicine: a reappraisal.
PG  - 137-54
LID - 10.1353/pbm.2012.0006 [doi]
AB  - This article addresses the philosophical and moral foundations of group-based and
      individualized therapy in connection with population care equality. The U.S. Food
      and Drug Administration (FDA) recently modified its public health policy by
      seeking to enhance the efficacy and equality of care through the approval of
      group-specific prescriptions and doses for some drugs. In the age of genomics,
      when individualization of care increasingly has become a major concern,
      investigating the relationship between population health, stratified medicine,
      and personalized therapy can improve our understanding of the ethical and
      biomedical implications of genomic medicine. I suggest that the need to optimize 
      population health through population substructure-sensitive research and the need
      to individualize care through genetically targeted therapies are not necessarily 
      incompatible. Accordingly, the article reconceptualizes a unified goal for modern
      scientific medicine in terms of individualized equal care.
FAU - Maglo, Koffi N
AU  - Maglo KN
AD  - Department of Philosophy, University of Cincinnati, Cincinnati, OH 45221-0374,
      USA. maglokn@ucmail.uc.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Perspect Biol Med
JT  - Perspectives in biology and medicine
JID - 0401132
SB  - IM
MH  - *Bioethics
MH  - Clinical Trials as Topic
MH  - Decision Support Systems, Clinical/legislation & jurisprudence/organization &
      administration
MH  - Evidence-Based Medicine/*ethics/legislation & jurisprudence
MH  - Genomics
MH  - Health Policy/legislation & jurisprudence
MH  - Humans
MH  - Morals
MH  - Pharmacogenetics
MH  - Precision Medicine/*ethics/statistics & numerical data
MH  - United States
EDAT- 2012/05/31 06:00
MHDA- 2012/09/25 06:00
CRDT- 2012/05/31 06:00
PHST- 2012/05/31 06:00 [entrez]
PHST- 2012/05/31 06:00 [pubmed]
PHST- 2012/09/25 06:00 [medline]
AID - S1529879512100090 [pii]
AID - 10.1353/pbm.2012.0006 [doi]
PST - ppublish
SO  - Perspect Biol Med. 2012 Winter;55(1):137-54. doi: 10.1353/pbm.2012.0006.


PMID- 22643720
OWN - NLM
STAT- MEDLINE
DCOM- 20120924
LR  - 20120530
IS  - 1529-8795 (Electronic)
IS  - 0031-5982 (Linking)
VI  - 55
IP  - 1
DP  - 2012 Winter
TI  - The foundation of physicianship.
PG  - 114-26
LID - 10.1353/pbm.2012.0002 [doi]
AB  - Although the practice of medicine continually changes in response to new
      biomedical understanding, novel technologies, and evolving cultural contexts, the
      ethical foundations of the clinical relationship between patient and physician
      paradoxically remain constant. There are fundamental characteristics with respect
      to character, behavior, and responsibilities that are descriptive of and
      necessary to the role of healer and that underpin the notion of physicianship.
      This article discusses the underlying characteristics or virtues that are
      necessary to the practice of medicine from the perspectives of three different
      philosophic traditions: the Aristotelian idea of phronesis as developed in the
      work of Edmund Pellegrino; the notion of alterity as framed by Emmanuel Levinas; 
      and the attributes necessary to healing as laid out in the kabbala.
FAU - Fuks, Abraham
AU  - Fuks A
AD  - Department of Medicine, McGill University, Montreal, QC, Canada.
      abraham.fuks@mcgill.ca
FAU - Brawer, James
AU  - Brawer J
FAU - Boudreau, J Donald
AU  - Boudreau JD
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Perspect Biol Med
JT  - Perspectives in biology and medicine
JID - 0401132
SB  - IM
MH  - Empathy
MH  - *Ethics, Medical
MH  - Humans
MH  - Mental Healing/psychology
MH  - Morals
MH  - Physician's Role
MH  - Physician-Patient Relations/*ethics
MH  - Physicians/*ethics/psychology
MH  - Social Values
EDAT- 2012/05/31 06:00
MHDA- 2012/09/25 06:00
CRDT- 2012/05/31 06:00
PHST- 2012/05/31 06:00 [entrez]
PHST- 2012/05/31 06:00 [pubmed]
PHST- 2012/09/25 06:00 [medline]
AID - S1529879512100077 [pii]
AID - 10.1353/pbm.2012.0002 [doi]
PST - ppublish
SO  - Perspect Biol Med. 2012 Winter;55(1):114-26. doi: 10.1353/pbm.2012.0002.


PMID- 22643717
OWN - NLM
STAT- MEDLINE
DCOM- 20120924
LR  - 20181201
IS  - 1529-8795 (Electronic)
IS  - 0031-5982 (Linking)
VI  - 55
IP  - 1
DP  - 2012 Winter
TI  - Ethics of the heart: ethical and policy challenges in the treatment of advanced
      heart failure.
PG  - 71-80
LID - 10.1353/pbm.2012.0009 [doi]
AB  - Heart failure is a major cause of morbidity and mortality in the United States
      and worldwide, accounting for immense health-care costs. Advanced therapies such 
      as transplantation, ventricular assist devices, and implantable cardioverter
      defibrillators have had great success in significantly improving life expectancy 
      and morbidity, however these advances have contributed substantially to the
      economic burden associated with this epidemic. Concomitantly, the accessibility
      of these advanced therapies is limited, due to a finite number of available
      organs for heart transplantation and, in the future, the economic costs
      associated with both transplant and device therapy. This article discusses
      ethical and policy challenges in the treatment of advanced heart failure,
      including decisions regarding procurement of hearts for transplant and allocation
      to recipients; and the complex issues surrounding the use of implantable
      cardioverter defibrillators and ventricular assist devices, including quality of 
      life, advanced directive planning in the context of these devices, and resource
      utilization. Based on these challenges, we recommend that a discussion of these
      complex matters be incorporated into cardiovascular training programs.
FAU - Fields, Anjali V
AU  - Fields AV
AD  - Division of Cardiology, University of Pennsylvania Perelman School of Medicine,
      Philadelphia, PA 19104, USA.
FAU - Kirkpatrick, James N
AU  - Kirkpatrick JN
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Perspect Biol Med
JT  - Perspectives in biology and medicine
JID - 0401132
SB  - IM
MH  - Decision Making/ethics
MH  - Defibrillators, Implantable/economics/ethics/statistics & numerical data
MH  - Health Policy/legislation & jurisprudence
MH  - Health Promotion
MH  - Health Services Accessibility/economics/ethics/legislation & jurisprudence
MH  - Heart Failure/*economics/*therapy
MH  - Heart Transplantation/economics/*ethics/legislation & jurisprudence
MH  - Heart-Assist Devices/economics/ethics/statistics & numerical data
MH  - Humans
MH  - Preventive Health Services/economics/legislation & jurisprudence/statistics &
      numerical data
MH  - Quality of Life
MH  - Stress, Psychological
MH  - United States
EDAT- 2012/05/31 06:00
MHDA- 2012/09/25 06:00
CRDT- 2012/05/31 06:00
PHST- 2012/05/31 06:00 [entrez]
PHST- 2012/05/31 06:00 [pubmed]
PHST- 2012/09/25 06:00 [medline]
AID - S1529879512100041 [pii]
AID - 10.1353/pbm.2012.0009 [doi]
PST - ppublish
SO  - Perspect Biol Med. 2012 Winter;55(1):71-80. doi: 10.1353/pbm.2012.0009.


PMID- 22643716
OWN - NLM
STAT- MEDLINE
DCOM- 20120924
LR  - 20211021
IS  - 1529-8795 (Electronic)
IS  - 0031-5982 (Linking)
VI  - 55
IP  - 1
DP  - 2012 Winter
TI  - Interpreting evidence: why values can matter as much as science.
PG  - 59-70
LID - 10.1353/pbm.2012.0007 [doi]
AB  - Despite increasing awareness of the ways in which non-epistemic values play roles
      in science, many scientists remain reluctant to acknowledge values at stake in
      their own work. Even when research clearly relates to risk assessment and
      establishing public policy, contexts in which the presence of values is less
      likely to be contentious, scientists tend to present such research as merely
      involving empirical questions about what the evidence is. As a result, debates
      over policy-related science tend to be framed as purely epistemic debates over
      the state of the evidence. We argue that this neglects the important ways that
      ethical and social values play legitimate roles in judgments about what we take
      to be evidence for a particular policy. Using the case of recent disputes about
      the relative safety of home birth, we argue that although the debate has been
      framed as a purely scientific one about the empirical evidence for home birth, it
      actually involves disagreements about underlying value assumptions. If our claims
      are correct, then in order to move the debate forward, scientists will need to
      engage in a critical discussion about the values at stake.
FAU - de Melo-Martin, Inmaculada
AU  - de Melo-Martin I
AD  - Division of Medical Ethics, Department of Public Health, Weill Cornell Medical
      College, NewYork, NY 10065, USA. imd2001@med.cornell.edu
FAU - Intemann, Kristen
AU  - Intemann K
LA  - eng
GR  - P20 GM103474/GM/NIGMS NIH HHS/United States
GR  - P20RR01645510/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Perspect Biol Med
JT  - Perspectives in biology and medicine
JID - 0401132
SB  - IM
MH  - Decision Making/ethics
MH  - Empirical Research
MH  - Evidence-Based Practice/*ethics/legislation & jurisprudence
MH  - Female
MH  - Home Childbirth/*ethics/legislation & jurisprudence
MH  - Humans
MH  - Midwifery/legislation & jurisprudence
MH  - Pregnancy
MH  - Pregnancy Complications/prevention & control
MH  - Public Policy/legislation & jurisprudence
MH  - Risk Factors
MH  - *Social Values
PMC - PMC3615245
MID - NIHMS453430
EDAT- 2012/05/31 06:00
MHDA- 2012/09/25 06:00
CRDT- 2012/05/31 06:00
PHST- 2012/05/31 06:00 [entrez]
PHST- 2012/05/31 06:00 [pubmed]
PHST- 2012/09/25 06:00 [medline]
AID - S152987951210003X [pii]
AID - 10.1353/pbm.2012.0007 [doi]
PST - ppublish
SO  - Perspect Biol Med. 2012 Winter;55(1):59-70. doi: 10.1353/pbm.2012.0007.


PMID- 22643375
OWN - NLM
STAT- MEDLINE
DCOM- 20120731
LR  - 20181201
IS  - 1938-808X (Electronic)
IS  - 1040-2446 (Linking)
VI  - 87
IP  - 6
DP  - 2012 Jun
TI  - Commentary: who will help the United States attain the goal of health equity?
PG  - 689-90
LID - 10.1097/ACM.0b013e318253a152 [doi]
AB  - A research report in this issue of Academic Medicine by Peek and colleagues
      describes how physician organizations are mounting different initiatives targeted
      at reducing health disparities. The study emphasizes how these organizations are 
      attempting to promote health equity through policies and programs focused on
      education, clinical care, research, and advocacy. They found that 68% of surveyed
      organizations have at least one initiative targeting health disparities.This
      commentary acknowledges the positive trend uncovered by Peek and colleagues which
      characterizes the engagement level of national physician organizations on this
      critical issue, and suggests four ways to enhance future efforts. First, health
      equity should be linked to overall quality of care and emerging initiatives aimed
      at transforming the delivery of health care. Second, the effect of such efforts
      can be magnified by evaluating what works and sharing best practices. Third,
      interventions must be targeted at institutions as well as individual physicians. 
      Finally, it should be emphasized that the driving rationale for physicians to
      strive for health equity is the ethical imperative to promote justice in health
      care.
FAU - Kirch, Darrell G
AU  - Kirch DG
AD  - American Medical Colleges, Washington, DC, USA.
FAU - Nivet, Marc A
AU  - Nivet MA
FAU - Berlin, Anne
AU  - Berlin A
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Acad Med
JT  - Academic medicine : journal of the Association of American Medical Colleges
JID - 8904605
SB  - IM
CON - Acad Med. 2012 Jun;87(6):694-700. PMID: 22534593
MH  - *Health Status Disparities
MH  - Healthcare Disparities/*ethnology
MH  - Humans
MH  - Societies, Medical/*organization & administration
EDAT- 2012/05/31 06:00
MHDA- 2012/08/01 06:00
CRDT- 2012/05/31 06:00
PHST- 2012/05/31 06:00 [entrez]
PHST- 2012/05/31 06:00 [pubmed]
PHST- 2012/08/01 06:00 [medline]
AID - 10.1097/ACM.0b013e318253a152 [doi]
AID - 00001888-201206000-00010 [pii]
PST - ppublish
SO  - Acad Med. 2012 Jun;87(6):689-90. doi: 10.1097/ACM.0b013e318253a152.


PMID- 22642880
OWN - NLM
STAT- MEDLINE
DCOM- 20130410
LR  - 20220419
IS  - 1750-1172 (Electronic)
IS  - 1750-1172 (Linking)
VI  - 7
DP  - 2012 May 29
TI  - Suggested guidelines for the diagnosis and management of urea cycle disorders.
PG  - 32
LID - 10.1186/1750-1172-7-32 [doi]
AB  - Urea cycle disorders (UCDs) are inborn errors of ammonia detoxification/arginine 
      synthesis due to defects affecting the catalysts of the Krebs-Henseleit cycle
      (five core enzymes, one activating enzyme and one mitochondrial
      ornithine/citrulline antiporter) with an estimated incidence of 1:8.000. Patients
      present with hyperammonemia either shortly after birth (~50%) or, later at any
      age, leading to death or to severe neurological handicap in many survivors.
      Despite the existence of effective therapy with alternative pathway therapy and
      liver transplantation, outcomes remain poor. This may be related to
      underrecognition and delayed diagnosis due to the nonspecific clinical
      presentation and insufficient awareness of health care professionals because of
      disease rarity. These guidelines aim at providing a trans-European consensus to: 
      guide practitioners, set standards of care and help awareness campaigns. To
      achieve these goals, the guidelines were developed using a Delphi methodology, by
      having professionals on UCDs across seven European countries to gather all the
      existing evidence, score it according to the SIGN evidence level system and draw 
      a series of statements supported by an associated level of evidence. The
      guidelines were revised by external specialist consultants, unrelated authorities
      in the field of UCDs and practicing pediatricians in training. Although the
      evidence degree did hardly ever exceed level C (evidence from non-analytical
      studies like case reports and series), it was sufficient to guide practice on
      both acute and chronic presentations, address diagnosis, management, monitoring, 
      outcomes, and psychosocial and ethical issues. Also, it identified knowledge
      voids that must be filled by future research. We believe these guidelines will
      help to: harmonise practice, set common standards and spread good practices with 
      a positive impact on the outcomes of UCD patients.
FAU - Haberle, Johannes
AU  - Haberle J
AD  - University Children's Hospital Zurich and Children's Research Centre, Zurich,
      8032, Switzerland. Johannes.Haeberle@kispi.uzh.ch
FAU - Boddaert, Nathalie
AU  - Boddaert N
FAU - Burlina, Alberto
AU  - Burlina A
FAU - Chakrapani, Anupam
AU  - Chakrapani A
FAU - Dixon, Marjorie
AU  - Dixon M
FAU - Huemer, Martina
AU  - Huemer M
FAU - Karall, Daniela
AU  - Karall D
FAU - Martinelli, Diego
AU  - Martinelli D
FAU - Crespo, Pablo Sanjurjo
AU  - Crespo PS
FAU - Santer, Rene
AU  - Santer R
FAU - Servais, Aude
AU  - Servais A
FAU - Valayannopoulos, Vassili
AU  - Valayannopoulos V
FAU - Lindner, Martin
AU  - Lindner M
FAU - Rubio, Vicente
AU  - Rubio V
FAU - Dionisi-Vici, Carlo
AU  - Dionisi-Vici C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120529
PL  - England
TA  - Orphanet J Rare Dis
JT  - Orphanet journal of rare diseases
JID - 101266602
RN  - 0 (Dietary Proteins)
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Diagnosis, Differential
MH  - Dietary Proteins/administration & dosage
MH  - Humans
MH  - Hyperammonemia/diagnosis/therapy
MH  - Infant
MH  - Infant, Newborn
MH  - Neonatal Screening
MH  - *Practice Guidelines as Topic
MH  - Prenatal Diagnosis
MH  - Urea Cycle Disorders, Inborn/*diagnosis/genetics/*therapy
PMC - PMC3488504
EDAT- 2012/05/31 06:00
MHDA- 2013/04/11 06:00
CRDT- 2012/05/31 06:00
PHST- 2011/11/24 00:00 [received]
PHST- 2012/04/06 00:00 [accepted]
PHST- 2012/05/31 06:00 [entrez]
PHST- 2012/05/31 06:00 [pubmed]
PHST- 2013/04/11 06:00 [medline]
AID - 1750-1172-7-32 [pii]
AID - 10.1186/1750-1172-7-32 [doi]
PST - epublish
SO  - Orphanet J Rare Dis. 2012 May 29;7:32. doi: 10.1186/1750-1172-7-32.


PMID- 22642777
OWN - NLM
STAT- MEDLINE
DCOM- 20121220
LR  - 20211021
IS  - 1179-1969 (Electronic)
IS  - 1170-229X (Linking)
VI  - 29
IP  - 6
DP  - 2012 Jun 1
TI  - Off-label prescribing in older patients.
PG  - 427-34
LID - 10.2165/11633520-000000000-00000 [doi]
AB  - The practice of off-label prescribing, i.e. prescribing drugs either for
      unregistered/unapproved therapeutic indications and age groups or using
      unregistered/unapproved doses or methods of administration, is common in older
      patients. This may be due to the poor representation of this group in
      pre-marketing clinical trials assessing therapeutic efficacy and safety of novel 
      therapies or merely to the fact that trials in a particular indication have not
      been undertaken. Off-label prescribing should not be viewed as scientifically or 
      ethically unsound when there are good clinical data to support a particular
      therapeutic indication. However, a number of steps should be followed in order to
      ensure therapeutic efficacy, reducing, at the same time, the risk of adverse drug
      reactions and/or medical litigation. This article discusses the current
      epidemiology and trends in off-label prescribing in older patients, the
      scientific and ethical justification of this practice, medico-legal implications,
      and proposed strategies for risk mitigation.
FAU - Jackson, Stephen H D
AU  - Jackson SH
AD  - Department of Clinical Gerontology, Kings Health Partners Academic Health Science
      Centre, London, UK. stephen.jackson@kcl.ac.uk
FAU - Jansen, Paul A F
AU  - Jansen PA
FAU - Mangoni, Arduino A
AU  - Mangoni AA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - New Zealand
TA  - Drugs Aging
JT  - Drugs & aging
JID - 9102074
SB  - IM
CIN - Drugs Aging. 2012 Jun 1;29(6):435-6. PMID: 22642778
MH  - Age Factors
MH  - Aged
MH  - Humans
MH  - Off-Label Use/ethics/*statistics & numerical data
MH  - Risk Management
EDAT- 2012/05/31 06:00
MHDA- 2012/12/21 06:00
CRDT- 2012/05/31 06:00
PHST- 2012/05/31 06:00 [entrez]
PHST- 2012/05/31 06:00 [pubmed]
PHST- 2012/12/21 06:00 [medline]
AID - 3 [pii]
AID - 10.2165/11633520-000000000-00000 [doi]
PST - ppublish
SO  - Drugs Aging. 2012 Jun 1;29(6):427-34. doi: 10.2165/11633520-000000000-00000.


PMID- 22642634
OWN - NLM
STAT- MEDLINE
DCOM- 20121005
LR  - 20211021
IS  - 1744-8298 (Electronic)
IS  - 1479-6678 (Linking)
VI  - 8
IP  - 3
DP  - 2012 May
TI  - Ethical issues in cardiac surgery.
PG  - 451-65
LID - 10.2217/fca.11.91 [doi]
AB  - While ethical behavior has always been part of cardiac surgical practice, ethical
      deliberation has only recently become an important component of cardiac surgical 
      practice. Issues such as informed consent, conflict of interest and professional 
      self-regulation, among many others, have increasingly attracted the attention of 
      cardiac surgeons. This article covers several broad topics of interest to cardiac
      surgeons and cardiologists and discusses several other topics more briefly. There
      is much uncertainty regarding what the future holds for cardiac surgical
      practice, research and culture and we also discuss the background of ethical
      issues to serve as a platform for envisioning what is to come.
FAU - Kavarana, Minoo N
AU  - Kavarana MN
AD  - Division of Pediatric Cardiothoracic Surgery, 96 Jonathan Lucas Street, CSB 424, 
      MSC 613, Charleston, SC 29425-6130, USA.
FAU - Sade, Robert M
AU  - Sade RM
LA  - eng
GR  - UL1 RR029882/RR/NCRR NIH HHS/United States
GR  - UL1 TR000062/TR/NCATS NIH HHS/United States
GR  - UL1RR029882/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - Future Cardiol
JT  - Future cardiology
JID - 101239345
SB  - IM
MH  - Cardiac Surgical Procedures/*ethics
MH  - Conflict of Interest
MH  - Decision Making
MH  - *Ethics, Medical
MH  - Humans
MH  - Informed Consent
MH  - Negotiating
MH  - Physicians/*ethics
MH  - Professional Autonomy
MH  - Thoracic Surgery/*ethics
MH  - United Kingdom
PMC - PMC3374583
MID - NIHMS379555
EDAT- 2012/05/31 06:00
MHDA- 2012/10/06 06:00
CRDT- 2012/05/31 06:00
PHST- 2012/05/31 06:00 [entrez]
PHST- 2012/05/31 06:00 [pubmed]
PHST- 2012/10/06 06:00 [medline]
AID - 10.2217/fca.11.91 [doi]
PST - ppublish
SO  - Future Cardiol. 2012 May;8(3):451-65. doi: 10.2217/fca.11.91.


PMID- 22641788
OWN - NLM
STAT- MEDLINE
DCOM- 20121106
LR  - 20211021
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 7
DP  - 2012 Jul
TI  - Deliberate use of placebos in clinical practice: what we really know.
PG  - 406-7
LID - 10.1136/medethics-2012-100695 [doi]
AB  - Increasingly a focus of research as well as media reports and online forums, the 
      use of placebos in clinical medicine extends beyond sugar pills and saline
      injections. Physician surveys conducted in various countries invariably report
      that placebos are routinely used clinically, impure placebos more frequently than
      the pure ones, and that physicians consider them to be of legitimate therapeutic 
      value. Inconsistent study methodologies and physician conceptualisations of
      placebos may complicate the interpretation of survey data, but hardly negate the 
      valuable insights these research findings provide. Because impure placebos are
      often not recognised as such by practitioners, they remain at the fringe of many 
      placebo-related debates, hence quietly absent from discussions concerning policy 
      and regulation. The apparent popularity of impure placebos used in clinical
      practice thus presents unresolved ethical concerns and should direct future
      discussion and research.
FAU - Harris, Cory S
AU  - Harris CS
AD  - School of Dietetics and Human Nutrition, McGill University, Montreal, Canada.
FAU - Raz, Amir
AU  - Raz A
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120528
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
RN  - 0 (Placebos)
SB  - IM
MH  - Attitude of Health Personnel
MH  - Communication
MH  - Humans
MH  - Mind-Body Relations, Metaphysical/*drug effects
MH  - Physician-Patient Relations
MH  - *Placebo Effect
MH  - Placebos/*administration & dosage
MH  - Practice Patterns, Physicians'/ethics/*statistics & numerical data
MH  - Surveys and Questionnaires
PMC - PMC3386649
EDAT- 2012/05/30 06:00
MHDA- 2012/11/07 06:00
CRDT- 2012/05/30 06:00
PHST- 2012/05/30 06:00 [entrez]
PHST- 2012/05/30 06:00 [pubmed]
PHST- 2012/11/07 06:00 [medline]
AID - medethics-2012-100695 [pii]
AID - 10.1136/medethics-2012-100695 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Jul;38(7):406-7. doi: 10.1136/medethics-2012-100695. Epub 2012
      May 28.


PMID- 22640951
OWN - NLM
STAT- MEDLINE
DCOM- 20120926
LR  - 20120529
IS  - 1532-8481 (Electronic)
IS  - 8755-7223 (Linking)
VI  - 28
IP  - 3
DP  - 2012 May-Jun
TI  - Student drug testing in nursing education.
PG  - 186-9
LID - 10.1016/j.profnurs.2011.11.017 [doi]
AB  - Nursing faculty and administrators have a responsibility to keep abreast of
      current research, legal regulations, and professional standards that affect
      students in the classroom and clinical setting. The purpose of this article is to
      examine whether empirical research supports the current trend of mandatory drug
      testing, provide a synopsis of current practice, and discuss the legal and
      ethical implications for nursing faculty.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Cotter, Valerie T
AU  - Cotter VT
AD  - University of Pennsylvania School of Nursing, Claire Fagin Hall, Philadelphia, PA
      19104, USA. cottervt@nursing.upenn.edu
FAU - Glasgow, Mary Ellen Smith
AU  - Glasgow ME
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Prof Nurs
JT  - Journal of professional nursing : official journal of the American Association of
      Colleges of Nursing
JID - 8511298
SB  - IM
MH  - Education, Nursing/*organization & administration
MH  - Humans
MH  - Mandatory Testing
MH  - *Substance Abuse Detection
EDAT- 2012/05/30 06:00
MHDA- 2012/09/27 06:00
CRDT- 2012/05/30 06:00
PHST- 2010/10/26 00:00 [received]
PHST- 2012/05/30 06:00 [entrez]
PHST- 2012/05/30 06:00 [pubmed]
PHST- 2012/09/27 06:00 [medline]
AID - S8755-7223(11)00201-8 [pii]
AID - 10.1016/j.profnurs.2011.11.017 [doi]
PST - ppublish
SO  - J Prof Nurs. 2012 May-Jun;28(3):186-9. doi: 10.1016/j.profnurs.2011.11.017.


PMID- 22640949
OWN - NLM
STAT- MEDLINE
DCOM- 20120926
LR  - 20151119
IS  - 1532-8481 (Electronic)
IS  - 8755-7223 (Linking)
VI  - 28
IP  - 3
DP  - 2012 May-Jun
TI  - Newly graduated nurses' perception of competence and possible predictors: a
      cross-sectional survey.
PG  - 170-81
LID - 10.1016/j.profnurs.2011.11.014 [doi]
AB  - The aim of this study was to describe newly graduated nurses' own perception of
      competence and to identify possible predictors influencing their perceptions. The
      target population included nurses who graduated from nursing colleges in June
      2006. Data collection was carried out from October 2006 until April 2007 using
      the Nurse Competence Scale (NCS), the California Critical Thinking Disposition
      Inventory, and the Research Utilization Questionnaire. The response rate was 33% 
      (n = 620). Pearson's chi-square test, Student t test, and regression analyses
      were used for statistical calculations. The respondents assessed their overall
      competence level as "good" and assessed themselves most competent in providing
      ethical and individualized nursing care. They assessed themselves least competent
      in evaluating outcomes and further development of patient care. Their use of
      competence explained between 40% (helping) and 10% (managing) of the variance
      within the NCS competence categories. Critical thinking (CT) was the most
      prominent predictor for perception of competence in all competence categories and
      the overall competence, alone explaining between 20% (NCS total score) and 9%
      (managing) of the variance. The finding that CT was a significant predictor for
      perception of competence may indicate that developing nursing students' CT
      abilities is valuable to increase newly graduated nurses' perception of
      competence.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Wangensteen, Sigrid
AU  - Wangensteen S
AD  - Department of Nursing, Karlstad University, Sweden. Sigrid.Wangensteen@hig.no
FAU - Johansson, Inger S
AU  - Johansson IS
FAU - Bjorkstrom, Monica E
AU  - Bjorkstrom ME
FAU - Nordstrom, Gun
AU  - Nordstrom G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Prof Nurs
JT  - Journal of professional nursing : official journal of the American Association of
      Colleges of Nursing
JID - 8511298
SB  - IM
MH  - *Clinical Competence
MH  - Cross-Sectional Studies
MH  - Humans
MH  - Nurses/*psychology
MH  - Surveys and Questionnaires
EDAT- 2012/05/30 06:00
MHDA- 2012/09/27 06:00
CRDT- 2012/05/30 06:00
PHST- 2010/09/17 00:00 [received]
PHST- 2012/05/30 06:00 [entrez]
PHST- 2012/05/30 06:00 [pubmed]
PHST- 2012/09/27 06:00 [medline]
AID - S8755-7223(11)00198-0 [pii]
AID - 10.1016/j.profnurs.2011.11.014 [doi]
PST - ppublish
SO  - J Prof Nurs. 2012 May-Jun;28(3):170-81. doi: 10.1016/j.profnurs.2011.11.014.


PMID- 22640588
OWN - NLM
STAT- MEDLINE
DCOM- 20130405
LR  - 20181201
IS  - 1558-4224 (Electronic)
IS  - 0749-0739 (Linking)
VI  - 28
IP  - 1
DP  - 2012 Apr
TI  - Prepurchase examination in ambulatory equine practice.
PG  - 207-47
LID - 10.1016/j.cveq.2012.03.001 [doi]
AB  - Prepurchase examination provides a significant opportunity for veterinarians to
      offer an important professional service to the equine industry. When the service 
      is performed competently and ethically, prospective buyers and sellers will
      recommend the examining veterinarian to fellow horse owners and professionals. To
      become comfortable with and skilled at performing prepurchase examinations, a
      veterinarian must understand the operational challenges associated with this
      service-and master them. Veterinarians performing prepurchase examinations should
      address the needs and manage the expectations of the prospective buyer, treat the
      seller and all parties with professional courtesy, be familiar with the intended 
      use of the horse, competently perform a thorough physical examination, and pay
      close attention to the medical record and report. Communicate clearly with all
      parties before, during, and after the examination. Feedback from staff and
      colleagues is critical to improving and refining the services offered. The
      veterinarian should work with staff to evaluate the processes used to deliver the
      prepurchase examination experience to clients and consult with mentors who are
      skilled in performing these services. Sharing your ideas for improving
      prepurchase examination with equine colleagues is a service to the veterinary
      profession and to the horse. Performing a prepurchase examination in the way
      described may sound like a "tall order," but once patient care and service goals 
      have been established, staff has been trained, and the process has been
      defined-the challenges become opportunities. The rewards include satisfied
      clients, reduced liability risk, increased profitability, and the satisfaction of
      having performed an interesting, valuable task to the best of one's abilities.
FAU - Werner, Harry W
AU  - Werner HW
AD  - Werner Equine, LLC, 20 Godard Road, North Granby, CT 06060, USA.
      hwwvmd@wernerequine.com
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Vet Clin North Am Equine Pract
JT  - The Veterinary clinics of North America. Equine practice
JID - 8511904
SB  - IM
MH  - Ambulatory Care
MH  - Animals
MH  - *Commerce
MH  - *Consumer Behavior
MH  - Horse Diseases/*diagnosis
MH  - Horses
MH  - Humans
MH  - Lameness, Animal/diagnosis
MH  - Physical Examination/*veterinary
MH  - Prospective Studies
MH  - Veterinary Medicine/*methods
EDAT- 2012/05/30 06:00
MHDA- 2013/04/06 06:00
CRDT- 2012/05/30 06:00
PHST- 2012/05/30 06:00 [entrez]
PHST- 2012/05/30 06:00 [pubmed]
PHST- 2013/04/06 06:00 [medline]
AID - S0749-0739(12)00013-2 [pii]
AID - 10.1016/j.cveq.2012.03.001 [doi]
PST - ppublish
SO  - Vet Clin North Am Equine Pract. 2012 Apr;28(1):207-47. doi:
      10.1016/j.cveq.2012.03.001.


PMID- 22640508
OWN - NLM
STAT- MEDLINE
DCOM- 20120926
LR  - 20181201
IS  - 1815-7920 (Electronic)
IS  - 1027-3719 (Linking)
VI  - 16
IP  - 4
DP  - 2012 Apr
TI  - The right to autonomy under operational research: should we reflect the spirit
      rather than letter of ethical guidelines?
PG  - 428
LID - 10.5588/ijtld.12.0025 [doi]
FAU - Rustomjee, Roxana
AU  - Rustomjee R
FAU - Zion, Deborah
AU  - Zion D
LA  - eng
PT  - Editorial
PT  - Comment
PL  - France
TA  - Int J Tuberc Lung Dis
JT  - The international journal of tuberculosis and lung disease : the official journal
      of the International Union against Tuberculosis and Lung Disease
JID - 9706389
RN  - 0 (Antitubercular Agents)
RN  - VJT6J7R4TR (Rifampin)
SB  - IM
CON - Int J Tuberc Lung Dis. 2012 Apr;16(4):455-61. PMID: 22640511
MH  - Antitubercular Agents/*therapeutic use
MH  - Humans
MH  - Rifampin/*therapeutic use
MH  - Tuberculosis, Multidrug-Resistant/*drug therapy
MH  - Tuberculosis, Pulmonary/*drug therapy
EDAT- 2012/05/30 06:00
MHDA- 2012/09/27 06:00
CRDT- 2012/05/30 06:00
PHST- 2012/05/30 06:00 [entrez]
PHST- 2012/05/30 06:00 [pubmed]
PHST- 2012/09/27 06:00 [medline]
AID - 10.5588/ijtld.12.0025 [doi]
PST - ppublish
SO  - Int J Tuberc Lung Dis. 2012 Apr;16(4):428. doi: 10.5588/ijtld.12.0025.


PMID- 22640504
OWN - NLM
STAT- MEDLINE
DCOM- 20121019
LR  - 20191210
IS  - 1557-9808 (Electronic)
IS  - 1557-9808 (Linking)
VI  - 15
IP  - 2
DP  - 2012 Jun
TI  - Placebo power.
PG  - 150-2
LID - 10.1053/j.tvir.2012.02.008 [doi]
AB  - A variable placebo response has been previously described in the multiple
      sclerosis (MS) literature and in sham surgical trials involving other patient
      populations. Conditioning and expectancy models are proposed to explain the
      biological mechanisms of a placebo response. Possibly, when neuroimmune
      mechanisms are involved in the disease process, placebo and treatment responses
      interact. The measurement of a placebo response related to endovascular
      procedures in MS may be scientifically and ethically challenging. Based on the
      factors associated with larger placebo responses, it is estimated that a
      significant placebo response may be associated with these procedures. The factors
      and mechanisms associated with marked placebo responses should be considered in
      the design of future studies related to the investigation of endovascular
      procedures for MS.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Knox, Katherine B
AU  - Knox KB
AD  - Department of Physical Medicine and Rehabilitation, University of Saskatchewan,
      Saskatchewan, Canada. katherine.knox@saskatoonhealthregion.ca
FAU - Kelly, Michael E
AU  - Kelly ME
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Tech Vasc Interv Radiol
JT  - Techniques in vascular and interventional radiology
JID - 9806675
SB  - IM
MH  - Humans
MH  - Multiple Sclerosis/*drug therapy/*surgery
MH  - Outcome Assessment, Health Care/*methods
MH  - *Placebo Effect
MH  - Treatment Outcome
EDAT- 2012/05/30 06:00
MHDA- 2012/10/20 06:00
CRDT- 2012/05/30 06:00
PHST- 2012/05/30 06:00 [entrez]
PHST- 2012/05/30 06:00 [pubmed]
PHST- 2012/10/20 06:00 [medline]
AID - S1089-2516(12)00027-3 [pii]
AID - 10.1053/j.tvir.2012.02.008 [doi]
PST - ppublish
SO  - Tech Vasc Interv Radiol. 2012 Jun;15(2):150-2. doi: 10.1053/j.tvir.2012.02.008.


PMID- 22640030
OWN - NLM
STAT- MEDLINE
DCOM- 20121011
LR  - 20220311
IS  - 1471-2458 (Electronic)
IS  - 1471-2458 (Linking)
VI  - 12
DP  - 2012 May 28
TI  - The cost of child health inequalities in Aotearoa New Zealand: a preliminary
      scoping study.
PG  - 384
LID - 10.1186/1471-2458-12-384 [doi]
AB  - BACKGROUND: Health inequalities have been extensively documented, internationally
      and in New Zealand. The cost of reducing health inequities is often perceived as 
      high; however, recent international studies suggest the cost of "doing nothing"
      is itself significant. This study aimed to develop a preliminary estimate of the 
      economic cost of health inequities between Maori (indigenous) and non-Maori
      children in New Zealand. METHODS: Standard quantitative epidemiological methods
      and "cost of illness" methodology were employed, within a Kaupapa Maori
      theoretical framework. Data were obtained from national data collections held by 
      the New Zealand Health Information Service and other health sector agencies.
      RESULTS: Preliminary estimates suggest child health inequities between Maori and 
      non-Maori in New Zealand are cost-saving to the health sector. However the
      societal costs are significant. A conservative "base case" scenario estimate is
      over $NZ62 million per year, while alternative costing methods yield larger costs
      of nearly $NZ200 million per annum. The total cost estimate is highly sensitive
      to the costing method used and Value of Statistical Life applied, as the cost of 
      potentially avoidable deaths of Maori children is the major contributor to this
      estimate. CONCLUSIONS: This preliminary study suggests that health sector
      spending is skewed towards non-Maori children despite evidence of greater Maori
      need. Persistent child health inequities result in significant societal economic 
      costs. Eliminating child health inequities, particularly in primary care access, 
      could result in significant economic benefits for New Zealand. However, there are
      conceptual, ethical and methodological challenges in estimating the economic cost
      of child health inequities. Re-thinking of traditional economic frameworks and
      development of more appropriate methodologies is required.
FAU - Mills, Clair
AU  - Mills C
AD  - Te Kupenga Hauora Maori, Faculty of Medical and Health Sciences, University of
      Auckland, Auckland, New Zealand. clair.mills@northlanddhb.org.nz
FAU - Reid, Papaarangi
AU  - Reid P
FAU - Vaithianathan, Rhema
AU  - Vaithianathan R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120528
PL  - England
TA  - BMC Public Health
JT  - BMC public health
JID - 100968562
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - *Cost of Illness
MH  - Databases, Factual
MH  - Epidemiologic Studies
MH  - Female
MH  - *Health Status Disparities
MH  - *Healthcare Disparities/ethnology
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - New Zealand/ethnology
MH  - Population Groups
PMC - PMC3404015
EDAT- 2012/05/30 06:00
MHDA- 2012/10/12 06:00
CRDT- 2012/05/30 06:00
PHST- 2011/11/24 00:00 [received]
PHST- 2012/05/28 00:00 [accepted]
PHST- 2012/05/30 06:00 [entrez]
PHST- 2012/05/30 06:00 [pubmed]
PHST- 2012/10/12 06:00 [medline]
AID - 1471-2458-12-384 [pii]
AID - 10.1186/1471-2458-12-384 [doi]
PST - epublish
SO  - BMC Public Health. 2012 May 28;12:384. doi: 10.1186/1471-2458-12-384.


PMID- 22639988
OWN - NLM
STAT- MEDLINE
DCOM- 20121106
LR  - 20220129
IS  - 1471-2458 (Electronic)
IS  - 1471-2458 (Linking)
VI  - 12
DP  - 2012 May 28
TI  - The Do-Well study: protocol for a randomised controlled trial, economic and
      qualitative process evaluations of domiciliary welfare rights advice for
      socio-economically disadvantaged older people recruited via primary health care.
PG  - 382
LID - 10.1186/1471-2458-12-382 [doi]
AB  - BACKGROUND: Older people in poor health are more likely to need extra money, aids
      and adaptations to allow them to remain independent and cope with ill health, yet
      in the UK many do not claim the welfare benefits to which they are entitled.
      Welfare rights advice interventions lead to greater welfare income, but have not 
      been rigorously evaluated for health benefits. This study will evaluate the
      effects on health and well-being of a domiciliary welfare rights advice service
      provided by local government or voluntary organisations in North East England for
      independent living, socio-economically disadvantaged older people (aged >/=60
      yrs), recruited from general (primary care) practices. METHODS/DESIGN: The study 
      is a pragmatic, individually randomised, single blinded, wait-list controlled
      trial of welfare rights advice versus usual care, with embedded economic and
      qualitative process evaluations. The qualitative study will examine whether the
      intervention is delivered as intended; explore responses to the intervention and 
      examine reasons for the trial findings; and explore the potential for translation
      of the intervention into routine policy and practice. The primary outcome is the 
      effect on health-related quality of life, measured using the CASP 19
      questionnaire. Volunteer men and women aged >/=60 years (1/household) will be
      identified from general practice patient registers. Patients in nursing homes or 
      hospitals at the time of recruitment will be excluded. General practice
      populations will be recruited from disadvantaged areas of North East England,
      including urban, rural and semi-rural areas, with no previous access to targeted 
      welfare rights advice services delivered to primary care patients. A minimum of
      750 participants will be randomised to intervention and control arms in a 1:1
      ratio. DISCUSSION: Achieving a trial design that is both ethical and acceptable
      to potential participants, required methodological compromises. The choice of
      follow-up length required a trade-off between sufficient time to demonstrate
      health impact and the need to allow the control group access to the intervention 
      as early as possible. The study will have implications for fundamental
      understanding of social inequalities and how to tackle them, and provides a model
      for similar evaluations of health-orientated social interventions. If the health 
      benefits of this intervention are proven, targeted welfare rights advice services
      should be extended to ensure widespread provision for older people and other
      vulnerable groups. CURRENT CONTROLLED TRIALS ISRCTN NUMBER: ISRCTN37380518.
FAU - Haighton, Catherine
AU  - Haighton C
AD  - Institute of Health and Society, Newcastle University, Baddiley Clark Building,
      Richardson Road, Newcastle, NE2 4AX, UK. katie.haighton@newcastle.ac.uk
FAU - Moffatt, Suzanne
AU  - Moffatt S
FAU - Howel, Denise
AU  - Howel D
FAU - McColl, Elaine
AU  - McColl E
FAU - Milne, Eugene
AU  - Milne E
FAU - Deverill, Mark
AU  - Deverill M
FAU - Rubin, Greg
AU  - Rubin G
FAU - Aspray, Terry
AU  - Aspray T
FAU - White, Martin
AU  - White M
LA  - eng
SI  - ISRCTN/ISRCTN37380518
GR  - 09/3009/02/DH_/Department of Health/United Kingdom
GR  - G0900686/MRC_/Medical Research Council/United Kingdom
GR  - BHF_/British Heart Foundation/United Kingdom
GR  - CRUK_/Cancer Research UK/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20120528
PL  - England
TA  - BMC Public Health
JT  - BMC public health
JID - 100968562
SB  - IM
MH  - Aged
MH  - *Counseling/supply & distribution
MH  - England
MH  - Female
MH  - Follow-Up Studies
MH  - Health Services for the Aged/*economics/legislation & jurisprudence
MH  - Health Status Indicators
MH  - Humans
MH  - Insurance Benefits/statistics & numerical data
MH  - Male
MH  - Outcome Assessment, Health Care/methods/statistics & numerical data
MH  - Patient Acceptance of Health Care/psychology
MH  - Patient Selection
MH  - Primary Health Care/*methods/standards
MH  - Qualitative Research
MH  - *Quality of Life/psychology
MH  - Residence Characteristics
MH  - Selection Bias
MH  - Single-Blind Method
MH  - Social Welfare/*economics/legislation & jurisprudence/psychology
MH  - Socioeconomic Factors
MH  - Surveys and Questionnaires
MH  - *Vulnerable Populations/legislation & jurisprudence/psychology
MH  - Waiting Lists
PMC - PMC3408348
EDAT- 2012/05/30 06:00
MHDA- 2012/11/07 06:00
CRDT- 2012/05/30 06:00
PHST- 2012/03/22 00:00 [received]
PHST- 2012/05/28 00:00 [accepted]
PHST- 2012/05/30 06:00 [entrez]
PHST- 2012/05/30 06:00 [pubmed]
PHST- 2012/11/07 06:00 [medline]
AID - 1471-2458-12-382 [pii]
AID - 10.1186/1471-2458-12-382 [doi]
PST - epublish
SO  - BMC Public Health. 2012 May 28;12:382. doi: 10.1186/1471-2458-12-382.


PMID- 22639917
OWN - NLM
STAT- MEDLINE
DCOM- 20131209
LR  - 20220309
IS  - 1447-0756 (Electronic)
IS  - 1341-8076 (Linking)
VI  - 39
IP  - 1
DP  - 2013 Jan
TI  - Outcome of Prolift mesh repair in treatment of pelvic organ prolapse and its
      effect on lower urinary tract symptoms: 5-year retrospective case study.
PG  - 243-9
LID - 10.1111/j.1447-0756.2012.01888.x [doi]
AB  - AIM: To assess the outcome of the Prolift Gynecare (Ethicon, Somerville, NJ, USA)
      mesh repair in the treatment of pelvic organ prolapse. This includes the
      anatomical success, complication rate and effect on associated lower urinary
      tract symptoms. MATERIAL AND METHODS: Retrospective case analysis of the above
      outcomes of 41 Prolift mesh repairs performed on 40 women over a 5-year period by
      a single surgeon in a private hospital in Australia. RESULTS: Successful
      anatomical correction and bulge symptom resolution were observed in 100% (2/2),
      91.6% (11/12) and 100% (27/27) of anterior, posterior and total Prolift,
      respectively. Prolapse in a non-treated compartment occurred in one woman. Two
      patients developed postoperative hematomas requiring surgical evacuation; one of 
      whom developed urinary retention for 2 weeks. Preoperative urinary symptoms were 
      reported in 35/40 (92%) of women, 8 of whom reported only urge symptoms and
      experienced complete resolution after Prolift. Resolution of stress urinary
      incontinence in women who had urodynamic stress incontinence with and without
      urge symptoms was reported in 60% (12/20) and 20% (1/5), respectively. This
      represented 62.5% (10/16) and 33.3% (3/9) of women who had total Prolift and
      posterior Prolift respectively. Average follow-up periods were 7 and 39 weeks in 
      38 and 18 women, respectively. CONCLUSION: This study shows that Prolift
      procedure is safe and effective in women with severe pelvic organ prolapse with
      resolution of most of the bulge and urinary urge symptoms. Total Prolift was
      effective in the treatment of associated mixed urinary incontinence.
CI  - (c) 2012 The Authors. Journal of Obstetrics and Gynaecology Research (c) 2012
      Japan Society of Obstetrics and Gynecology.
FAU - Gad, Nader
AU  - Gad N
AD  - Department of Obstetrics and Gynecology, Royal Darwin Hospital, Darwin, Northern 
      Territory Flinders University, Adelaide, South Australia, Australia.
      drnadergad@hotmail.com
FAU - Duvvuru, Amulya
AU  - Duvvuru A
FAU - Burchgart, Brook
AU  - Burchgart B
LA  - eng
PT  - Journal Article
DEP - 20120528
PL  - Australia
TA  - J Obstet Gynaecol Res
JT  - The journal of obstetrics and gynaecology research
JID - 9612761
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Pelvic Organ Prolapse/complications/physiopathology/*surgery
MH  - Retrospective Studies
MH  - Surgical Mesh/adverse effects
MH  - Treatment Outcome
MH  - Urinary Incontinence, Stress/etiology/physiopathology/*surgery
MH  - Urinary Incontinence, Urge/etiology/physiopathology/*surgery
MH  - Urodynamics/*physiology
EDAT- 2012/05/30 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/05/30 06:00
PHST- 2012/05/30 06:00 [entrez]
PHST- 2012/05/30 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1111/j.1447-0756.2012.01888.x [doi]
PST - ppublish
SO  - J Obstet Gynaecol Res. 2013 Jan;39(1):243-9. doi:
      10.1111/j.1447-0756.2012.01888.x. Epub 2012 May 28.


PMID- 22639328
OWN - NLM
STAT- MEDLINE
DCOM- 20130102
LR  - 20211021
IS  - 1573-3599 (Electronic)
IS  - 1059-7700 (Linking)
VI  - 21
IP  - 5
DP  - 2012 Oct
TI  - Prenatal treatment of congenital adrenal hyperplasia-not standard of care.
PG  - 615-24
LID - 10.1007/s10897-012-9508-8 [doi]
AB  - Congenital adrenal hyperplasia (CAH) due to steroid 21-hydroxylase deficiency is 
      a common autosomal recessive disorder due to mutations in the CYP21A2 gene. Since
      genetic counselors play a crucial role in educating families about inherited
      disorders, they need to have thorough knowledge regarding the pathophysiology of 
      CAH especially the effects on the fetus, the complex genetics of this disorder,
      and the controversies surrounding experimental prenatal dexamethasone treatment. 
      Affected female fetuses may have varying degree of virilization of the external
      genitalia. Starting in the 1980's, supraphysiologic glucocorticoid treatment was 
      used to decrease the virilization of the external genitalia of affected female
      fetuses. However, recent clinical observations, animal studies and greater
      awareness of the details of human fetal adrenal physiology raise concerns
      regarding the safety of this prenatal treatment. We review the pathophysiology of
      CAH, the safety and ethical considerations of prenatal dexamethasone treatment
      and the views of multiple medical societies that conclude that this experimental 
      therapy should only be done in prospective trials approved by ethical review
      boards.
FAU - Witchel, Selma Feldman
AU  - Witchel SF
AD  - Department of Pediatrics, Division of Pediatric Endocrinology, Children's
      Hospital of Pittsburgh of UPMC, University of Pittsburgh, PA 15224, USA.
      selma.witchel@chp.edu
FAU - Miller, Walter L
AU  - Miller WL
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120526
PL  - United States
TA  - J Genet Couns
JT  - Journal of genetic counseling
JID - 9206865
RN  - EC 1.14.14.16 (CYP21A2 protein, human)
RN  - EC 1.14.14.16 (Steroid 21-Hydroxylase)
SB  - IM
MH  - Adrenal Hyperplasia, Congenital/diagnosis/enzymology/genetics/*therapy
MH  - Animals
MH  - Female
MH  - Genetic Counseling
MH  - Humans
MH  - Male
MH  - Mutation
MH  - *Prenatal Diagnosis
MH  - Steroid 21-Hydroxylase/genetics
EDAT- 2012/05/29 06:00
MHDA- 2013/01/03 06:00
CRDT- 2012/05/29 06:00
PHST- 2011/12/23 00:00 [received]
PHST- 2012/05/01 00:00 [accepted]
PHST- 2012/05/29 06:00 [entrez]
PHST- 2012/05/29 06:00 [pubmed]
PHST- 2013/01/03 06:00 [medline]
AID - 10.1007/s10897-012-9508-8 [doi]
PST - ppublish
SO  - J Genet Couns. 2012 Oct;21(5):615-24. doi: 10.1007/s10897-012-9508-8. Epub 2012
      May 26.


PMID- 22639112
OWN - NLM
STAT- MEDLINE
DCOM- 20130110
LR  - 20211021
IS  - 1549-490X (Electronic)
IS  - 1083-7159 (Linking)
VI  - 17
IP  - 5
DP  - 2012
TI  - A pilot study of a culturally targeted video intervention to increase
      participation of African American patients in cancer clinical trials.
PG  - 708-14
LID - 10.1634/theoncologist.2011-0454 [doi]
AB  - PURPOSE: Barriers to clinical trial participation among African American cancer
      patients are well characterized in the literature. Attitudinal barriers
      encompassing fear, distrust, and concerns about ethical misconduct are also well 
      documented. To increase trial accrual, these attitudes must be adequately
      addressed, yet there remains a lack of targeted interventions toward this end. We
      developed a 15-minute culturally targeted video designed to impact six specific
      attitudes of African American cancer patients toward therapeutic trials. We
      conducted a pilot study to test in the first such intervention to increase
      intention to enroll. PATIENTS AND METHODS: The primary study outcome was
      self-reported likelihood to participate in a therapeutic trial. Using a mixed
      methods approach, we developed the Attitudes and Intention to Enroll in
      Therapeutic Clinical Trials (AIET) instrument, a 30-item questionnaire measuring 
      six attitudinal barriers to African American trial participation. We enrolled 108
      eligible active treatment patients at a large urban cancer institute. McNemar's
      test for matched pairs was used to assess changes in attitudes and likelihood to 
      enroll in a clinical trial at baseline and immediately after the video. Pre- and 
      post-video AIET summative scores were analyzed by paired t-test for each
      attitudinal barrier. RESULTS: Patients' likelihood of enrolling in a clinical
      trial significantly increased post-video with 36% of the sample showing positive 
      changes in intention [McNemar's chi(2) = 33.39, p < .001]. Paired t-tests showed 
      significant changes in all six attitudinal barriers measured via AIET summative
      scores from pre- to post-video. CONCLUSION: These data suggest utility of our
      video for increasing African American participation in clinical trials.
FAU - Banda, Deliya R
AU  - Banda DR
AD  - Medstar Health Research Institute, Hyattsville, Maryland, USA.
      Deliya.R.Banda@medstar.net
FAU - Libin, Alexander V
AU  - Libin AV
FAU - Wang, Hong
AU  - Wang H
FAU - Swain, Sandra M
AU  - Swain SM
LA  - eng
GR  - RC1 MD004185/MD/NIMHD NIH HHS/United States
GR  - 1RC1MD004185-01/MD/NIMHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - Oncologist
JT  - The oncologist
JID - 9607837
SB  - IM
MH  - Adult
MH  - African Americans/*psychology
MH  - Aged
MH  - Aged, 80 and over
MH  - Clinical Trials as Topic/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/*ethnology/therapy
MH  - Patient Education as Topic/*methods
MH  - Pilot Projects
MH  - Research Design
MH  - Surveys and Questionnaires
MH  - Videotape Recording/*methods
PMC - PMC3360910
EDAT- 2012/05/29 06:00
MHDA- 2013/01/11 06:00
CRDT- 2012/05/29 06:00
PHST- 2012/05/29 06:00 [entrez]
PHST- 2012/05/29 06:00 [pubmed]
PHST- 2013/01/11 06:00 [medline]
AID - 17/5/708 [pii]
AID - 10.1634/theoncologist.2011-0454 [doi]
PST - ppublish
SO  - Oncologist. 2012;17(5):708-14. doi: 10.1634/theoncologist.2011-0454.


PMID- 22638856
OWN - NLM
STAT- MEDLINE
DCOM- 20130109
LR  - 20211021
IS  - 1559-1166 (Electronic)
IS  - 0895-8696 (Linking)
VI  - 48
IP  - 1
DP  - 2012 Sep
TI  - Transplantation of placenta-derived mesenchymal stem cells in the EAE mouse model
      of MS.
PG  - 176-84
LID - 10.1007/s12031-012-9805-6 [doi]
AB  - Stem cell-based regenerative medicine raises great hope for the treatment of
      multiple sclerosis (MS). Bone marrow-derived mesenchymal stem cells (BM-MSCs) are
      being tested in clinical trials. Bone marrow is the traditional source of human
      MSCs, but human term placenta appears to be an excellent alternative because of
      its availability, without ethical issues. In this study, the therapeutic effect
      of human placental MSCs (PL-MSCs) was evaluated in experimental autoimmune
      encephalomyelitis (EAE), the mice model of MS. EAE mice were transplanted
      intra-cerebrally with PL-MSCs or with the vehicle saline 5 or 10 days after first
      MOG injection. The mice were monitored for a month after therapy. A daily EAE
      score revealed a decrease in disease severity in the transplanted animals when
      compared to saline. Survival was significantly higher in the transplanted
      animals. In vitro experiments demonstrated that conditioned media from
      LPS-activated astrocytes stimulated PL-MSCs to express the gene
      TNF-alpha-stimulated gene/protein 6 (TSG-6). The same mRNA expression was
      obtained when PL-MSCs were exposed to TNF-alpha or IL1-beta. These results
      demonstrate that PL-MSCs have a therapeutic effect in the EAE mice model. We
      assume that this effect is caused by reduction of the anti-inflammatory protein, 
      TSG-6, of the inflammatory damage.
FAU - Fisher-Shoval, Yonit
AU  - Fisher-Shoval Y
AD  - Neuroscience Laboratory, Felsenstein Medical Research Center-Tel Aviv University,
      Petah Tikva, Israel.
FAU - Barhum, Yael
AU  - Barhum Y
FAU - Sadan, Ofer
AU  - Sadan O
FAU - Yust-Katz, Shlomit
AU  - Yust-Katz S
FAU - Ben-Zur, Tali
AU  - Ben-Zur T
FAU - Lev, Nirit
AU  - Lev N
FAU - Benkler, Chen
AU  - Benkler C
FAU - Hod, Moshe
AU  - Hod M
FAU - Melamed, Eldad
AU  - Melamed E
FAU - Offen, Daniel
AU  - Offen D
LA  - eng
PT  - Journal Article
DEP - 20120526
PL  - United States
TA  - J Mol Neurosci
JT  - Journal of molecular neuroscience : MN
JID - 9002991
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Astrocytes/cytology
MH  - Brain/cytology
MH  - Cerebral Ventricles/cytology
MH  - Disease Models, Animal
MH  - Encephalomyelitis, Autoimmune, Experimental/pathology/*therapy
MH  - Female
MH  - Humans
MH  - Mesenchymal Stem Cell Transplantation/*methods
MH  - Mesenchymal Stem Cells/*cytology
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Mice, Inbred C57BL
MH  - Multiple Sclerosis/pathology/*therapy
MH  - Placenta/*cytology
MH  - Pregnancy
MH  - Primary Cell Culture
MH  - Severity of Illness Index
MH  - Spinal Cord/cytology
MH  - Spleen/cytology
MH  - Transplantation, Heterologous
EDAT- 2012/05/29 06:00
MHDA- 2013/01/10 06:00
CRDT- 2012/05/29 06:00
PHST- 2012/04/05 00:00 [received]
PHST- 2012/05/03 00:00 [accepted]
PHST- 2012/05/29 06:00 [entrez]
PHST- 2012/05/29 06:00 [pubmed]
PHST- 2013/01/10 06:00 [medline]
AID - 10.1007/s12031-012-9805-6 [doi]
PST - ppublish
SO  - J Mol Neurosci. 2012 Sep;48(1):176-84. doi: 10.1007/s12031-012-9805-6. Epub 2012 
      May 26.


PMID- 22637787
OWN - NLM
STAT- MEDLINE
DCOM- 20130104
LR  - 20151119
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 10
DP  - 2012 Oct
TI  - Implementing structured, multiprofessional medical ethical decision-making in a
      neonatal intensive care unit.
PG  - 596-601
AB  - BACKGROUND: In neonatal intensive care, a child's death is often preceded by a
      medical decision. Nurses, social workers and pastors, however, are often excluded
      from ethical case deliberation. If multiprofessional ethical case deliberations
      do take place, participants may not always know how to perform to the fullest.
      SETTING: A level-IIID neonatal intensive care unit of a paediatric teaching
      hospital in the Netherlands. METHODS: Structured multiprofessional medical
      ethical decision-making (MEDM) was implemented to help overcome problems
      experienced. Important features were: all professionals who are directly involved
      with the patient contribute to MEDM; a five-step procedure is used: exploration, 
      agreement on the ethical dilemma/investigation of solutions, analysis of
      solutions, decision-making, planning actions; meetings are chaired by an
      impartial ethicist. A 15-item questionnaire to survey staff perceptions on this
      intervention just before and 8 months after implementation was developed.
      RESULTS: Before and after response rates were 91/105 (87%) and 85/113 (75%).
      Factor analysis on the questionnaire suggested a four-factor structure:
      participants' role; structure of MEDM; content of ethical deliberation; and
      documentation of decisions/conclusions. Effect sizes were 1.67 (p<0.001), 0.69
      (p<0.001) and 0.40 (p<0.01) for the first three factors respectively, but only
      0.07 (p=0.65) for the fourth factor. Nurses' perceptions of improvement did not
      significantly exceed those of physicians. CONCLUSION: Professionals involved in
      ethical case deliberation perceived that the process of decision-making had
      improved; they were more positive about the structure of meetings, their own role
      and, to some extent, the content of ethical deliberation. Documentation of
      decisions/conclusions requires further improvement.
FAU - de Boer, Jacoba Coby
AU  - de Boer JC
AD  - Department of Paediatrics, Division of Neonatology, Erasmus University Medical
      Centre, Sophia Children's Hospital, Dr Molewaterplein 60, PO Box 2060, 3000 CB
      Rotterdam, Netherlands. j.boer@erasmusmc.nl
FAU - van Blijderveen, Geja
AU  - van Blijderveen G
FAU - van Dijk, Gert
AU  - van Dijk G
FAU - Duivenvoorden, Hugo J
AU  - Duivenvoorden HJ
FAU - Williams, Monique
AU  - Williams M
LA  - eng
PT  - Journal Article
DEP - 20120525
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Adult
MH  - Attitude of Health Personnel
MH  - Chaplaincy Service, Hospital
MH  - Decision Making/*ethics
MH  - Ethics, Medical
MH  - Ethics, Nursing
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - *Intensive Care Units, Neonatal
MH  - *Intensive Care, Neonatal/ethics/methods/trends
MH  - *Interdisciplinary Communication
MH  - Male
MH  - Middle Aged
MH  - Netherlands
MH  - Pastoral Care
MH  - *Patient Care Team/ethics/standards/trends
MH  - Social Work
MH  - Surveys and Questionnaires
EDAT- 2012/05/29 06:00
MHDA- 2013/01/05 06:00
CRDT- 2012/05/29 06:00
PHST- 2012/05/29 06:00 [entrez]
PHST- 2012/05/29 06:00 [pubmed]
PHST- 2013/01/05 06:00 [medline]
AID - medethics-2011-100250 [pii]
AID - 10.1136/medethics-2011-100250 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Oct;38(10):596-601. doi: 10.1136/medethics-2011-100250. Epub
      2012 May 25.


PMID- 22637376
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20220129
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 3
DP  - 2012
TI  - Detailed protocol for the lifestyle intervention in the BeWEL randomised
      controlled trial of weight loss in adults who have had a colorectal adenoma.
LID - 10.1136/bmjopen-2012-001276 [doi]
LID - e001276 [pii]
AB  - INTRODUCTION: The BeWEL study is aimed at assessing the impact of a personalised 
      lifestyle programme on body weight in people at risk of developing colorectal
      adenomas. The study is a two-arm multicentre randomised controlled trial
      comparing the BeWEL lifestyle programme against usual care. Over 12 months, 316
      people who have had a colorectal adenoma removed through the national screening
      programme will be randomised to provide 80% power to detect a weight loss
      (primary outcome) of 7% over 12 months. METHODS: The 12-month intervention will
      be delivered by lifestyle counsellors via three face-to-face visits followed by
      nine monthly telephone support calls. Consultant endorsement for the study will
      be stressed. An individualised caloric prescription based on estimates for weight
      maintenance -600 kcal will be calculated. Motivational interviewing techniques
      will be used to identify personal motivations for weight change and ways to
      improve perceived self-efficacy. The programme will utilise personalised diet and
      physical activity data from baseline measures to set behavioural goals. A range
      of behavioural strategies will be employed to support lifestyle change including 
      goal setting, identifying specific implementation intentions, self-monitoring and
      feedback. Emphasis will be placed on self-monitoring body weight, and weighing
      scales will be provided. Programme acceptability will be explored
      postintervention with indepth interviews. Compliance and impact will be assessed 
      by baseline and follow-up measures of diet by self-report, activity by
      accelerometry and anthropometry. ETHICS AND DISSEMINATION: Ethical approval has
      been obtained from the Tayside Committee on Medical Research Ethics.
      Dissemination of results will focus on publications in peer-reviewed journals,
      presentations at national/international cancer meetings and NHS groups. In
      addition, the work will be communicated to the public through forums such at The 
      Scottish Cancer Prevention Network (http://www.cancerpreventionscotland.co.uk/). 
      The trial is registered with Current Controlled Trials (International Standard
      Randomised Controlled Trials No: ISRCTN53033856).
FAU - Caswell, Stephen
AU  - Caswell S
AD  - Centre for Research into Cancer Prevention and Screening, Medical Research
      Institute, Population Health Sciences Division, University of Dundee, Dundee, UK.
FAU - Craigie, Angela M
AU  - Craigie AM
FAU - Wardle, Jane
AU  - Wardle J
FAU - Stead, Martine
AU  - Stead M
FAU - Anderson, Annie
AU  - Anderson A
LA  - eng
GR  - 14133/CRUK_/Cancer Research UK/United Kingdom
GR  - G0802030/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
DEP - 20120525
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3364449
EDAT- 2012/05/29 06:00
MHDA- 2012/05/29 06:01
CRDT- 2012/05/29 06:00
PHST- 2012/05/29 06:00 [entrez]
PHST- 2012/05/29 06:00 [pubmed]
PHST- 2012/05/29 06:01 [medline]
AID - bmjopen-2012-001276 [pii]
AID - 10.1136/bmjopen-2012-001276 [doi]
PST - epublish
SO  - BMJ Open. 2012 May 25;2(3). pii: bmjopen-2012-001276. doi:
      10.1136/bmjopen-2012-001276. Print 2012.


PMID- 22635298
OWN - NLM
STAT- MEDLINE
DCOM- 20121019
LR  - 20181201
IS  - 1943-3662 (Electronic)
IS  - 1093-6793 (Linking)
VI  - 40
IP  - 2
DP  - 2012
TI  - On the roots of modern forensic psychiatry: ethics ramifications.
PG  - 246-52
AB  - The historical origin of modern forensic psychiatry, as well as the circumstances
      of its evolution, may be defined and described from several vantage points. In
      this article I present a critical reading of Richard J. Bonnie's article,
      published in the Journal, in which he assigned the budding of modern forensic
      psychiatry to the 20th century. Although I concur with Bonnie's historical
      analysis, as well as with his underlying moral approach, I suggest that, to
      attain a broader view of the contribution of forensic psychiatry, it is important
      to be open to additional narratives of its development. The supplemental
      narrative that I offer highlights values other than those that were highlighted
      by Bonnie that are deeply rooted and equally inherent in the practice of forensic
      psychiatry. Thus, awareness of the two complementary narratives enables a
      stereoscopic view that encompasses the full picture regarding the roots of
      forensic psychiatry.
FAU - Gold, Azgad
AU  - Gold A
AD  - Department of Psychiatry, Herzog Hospital, Givat Shaul, P.O. Box 3900, Jerusalem,
      Israel 91351. azgadgo@gmail.com
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - J Am Acad Psychiatry Law
JT  - The journal of the American Academy of Psychiatry and the Law
JID - 9708963
SB  - IM
CON - J Am Acad Psychiatry Law. 2010;38(4):570-6. PMID: 21156919
MH  - Forensic Psychiatry/*history
MH  - Humans
EDAT- 2012/05/29 06:00
MHDA- 2012/10/20 06:00
CRDT- 2012/05/29 06:00
PHST- 2012/05/29 06:00 [entrez]
PHST- 2012/05/29 06:00 [pubmed]
PHST- 2012/10/20 06:00 [medline]
AID - 40/2/246 [pii]
PST - ppublish
SO  - J Am Acad Psychiatry Law. 2012;40(2):246-52.


PMID- 22635297
OWN - NLM
STAT- MEDLINE
DCOM- 20121019
LR  - 20181201
IS  - 1943-3662 (Electronic)
IS  - 1093-6793 (Linking)
VI  - 40
IP  - 2
DP  - 2012
TI  - Covert medication in psychiatric emergencies: is it ever ethically permissible?
PG  - 239-45
AB  - Covert administration of medications to patients, defined as the administration
      of medication to patients without their knowledge, is a practice surrounded by
      clinical, legal, ethics-related, and cultural controversy. Many psychiatrists
      would be likely to advocate that the practice of covert medication in emergency
      psychiatry is not clinically, ethically, or legally acceptable. This article
      explores whether there may be exceptions to this stance that would be ethical. We
      first review the standard of emergency psychiatric care. Although we could
      identify no published empirical studies of covert administration of medicine in
      emergency departments, we review the prevalence of this practice in other
      clinical settings. While the courts have not ruled with respect to covert
      medication, we discuss the evolving legal landscape of informed consent,
      competency, and the right to refuse treatment. We discuss dilemmas regarding the 
      ethics involved in this practice, including the tensions among autonomy,
      beneficence, and duty to protect. We explore how differences between cultures
      regarding the value placed on individual versus family autonomy may affect
      perspectives with regard to this practice. We investigate how consumers view this
      practice and their treatment preferences during a psychiatric emergency. Finally,
      we discuss psychiatric advance directives and explore how these contracts may
      affect the debate over the practice.
FAU - Hung, Erick K
AU  - Hung EK
AD  - Department of Psychiatry, University of California, San Francisco, CA, USA.
      erick.hung@ucsf.edu
FAU - McNiel, Dale E
AU  - McNiel DE
FAU - Binder, Renee L
AU  - Binder RL
LA  - eng
PT  - Journal Article
PT  - Legal Case
PL  - United States
TA  - J Am Acad Psychiatry Law
JT  - The journal of the American Academy of Psychiatry and the Law
JID - 9708963
SB  - IM
CIN - J Am Acad Psychiatry Law. 2013;41(1):154. PMID: 23503186
MH  - Advance Directives/psychology
MH  - Crisis Intervention/legislation & jurisprudence/*methods
MH  - Culture
MH  - Drug Therapy/*ethics
MH  - Emergency Services, Psychiatric/legislation & jurisprudence
MH  - Ethics, Professional
MH  - Humans
MH  - Informed Consent/*ethics/legislation & jurisprudence
MH  - Mental Disorders/*drug therapy
MH  - United States
EDAT- 2012/05/29 06:00
MHDA- 2012/10/20 06:00
CRDT- 2012/05/29 06:00
PHST- 2012/05/29 06:00 [entrez]
PHST- 2012/05/29 06:00 [pubmed]
PHST- 2012/10/20 06:00 [medline]
AID - 40/2/239 [pii]
PST - ppublish
SO  - J Am Acad Psychiatry Law. 2012;40(2):239-45.


PMID- 22635286
OWN - NLM
STAT- MEDLINE
DCOM- 20121019
LR  - 20181201
IS  - 1943-3662 (Electronic)
IS  - 1093-6793 (Linking)
VI  - 40
IP  - 2
DP  - 2012
TI  - Ethics guidelines in a widened context.
PG  - 168-70
FAU - Young, John L
AU  - Young JL
LA  - eng
PT  - Editorial
PT  - Legal Case
PL  - United States
TA  - J Am Acad Psychiatry Law
JT  - The journal of the American Academy of Psychiatry and the Law
JID - 9708963
SB  - IM
CIN - J Am Acad Psychiatry Law. 2014;42(4):533-4. PMID: 25492081
MH  - Forensic Psychiatry/*ethics/*legislation & jurisprudence
MH  - United States
EDAT- 2012/05/29 06:00
MHDA- 2012/10/20 06:00
CRDT- 2012/05/29 06:00
PHST- 2012/05/29 06:00 [entrez]
PHST- 2012/05/29 06:00 [pubmed]
PHST- 2012/10/20 06:00 [medline]
AID - 40/2/168 [pii]
PST - ppublish
SO  - J Am Acad Psychiatry Law. 2012;40(2):168-70.


PMID- 22634828
OWN - NLM
STAT- MEDLINE
DCOM- 20121001
LR  - 20190907
IS  - 1678-4561 (Electronic)
IS  - 1413-8123 (Linking)
VI  - 17
IP  - 5
DP  - 2012 May
TI  - [Dental pain as the motive for absenteeism in a sample of workers].
PG  - 1357-63
LID - S1413-81232012000500029 [pii]
AB  - The aim of this study was to analyze the prevalence of dental pain, absenteeism
      induced by dental pain, and the association with socio-demographic
      characteristics. The research had a cross-sectional design using a random sample 
      of 170 municipal employees from the City of Venda Nova do Imigrante, Espirito
      Santo state, Brazil, selected from a universe of 545 individuals. Data was
      collected using a 27-item questionnaire applied by a municipal worker. The
      comparison of dental pain and prevalence of absenteeism with socio-demographic
      and functional characteristics was verified using Fisher's Exact test. The
      research project was approved by an Ethics Research Committee. The prevalence of 
      dental pain among the employees was 43% and half of these felt dental pains at
      work. Absenteeism related to dental pain was 23.4%. Workers with lower
      instruction level were twice as likely to have dental pain (OR = 2,144, IC95% =
      1,141; 4,030). Male subjects (OR = 5,714, IC95% = 1,773; 18,416), less years of
      education (OR = 4,875, IC95% = 1,405; 16,909) and less family income (OR = 3,613,
      IC95% = 0,931; 14,021) were related with higher absenteeism caused by dental
      pain. High dental pain frequency revealed in this study indicates that health
      promotion policies are needed to improve the quality of life of workers.
FAU - Miotto, Maria Helena Monteiro de Barros
AU  - Miotto MH
AD  - Universidade Federal do Espirito Santo, Vitoria, ES, Brazil.
      mhmiotto@terra.com.br
FAU - Silotti, Jean Carlos Bazoni
AU  - Silotti JC
FAU - Barcellos, Ludmilla Awad
AU  - Barcellos LA
LA  - por
PT  - English Abstract
PT  - Journal Article
TT  - Dor dentaria como motivo de absenteismo em uma populacao de trabalhadores.
PL  - Brazil
TA  - Cien Saude Colet
JT  - Ciencia & saude coletiva
JID - 9713483
SB  - IM
MH  - *Absenteeism
MH  - Adolescent
MH  - Adult
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Occupational Health
MH  - Prevalence
MH  - Surveys and Questionnaires
MH  - Toothache/*epidemiology
MH  - Young Adult
EDAT- 2012/05/29 06:00
MHDA- 2012/10/02 06:00
CRDT- 2012/05/29 06:00
PHST- 2012/05/29 06:00 [entrez]
PHST- 2012/05/29 06:00 [pubmed]
PHST- 2012/10/02 06:00 [medline]
AID - S1413-81232012000500029 [pii]
AID - 10.1590/s1413-81232012000500029 [doi]
PST - ppublish
SO  - Cien Saude Colet. 2012 May;17(5):1357-63. doi: 10.1590/s1413-81232012000500029.


PMID- 22634285
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20181201
IS  - 1460-2350 (Electronic)
IS  - 0268-1161 (Linking)
VI  - 27
IP  - 7
DP  - 2012 Jul
TI  - Lack of ethical approval and omission of experimental evidence.
PG  - 1881
LID - 10.1093/humrep/des167 [doi]
FAU - Van Steirteghem, Andre
AU  - Van Steirteghem A
LA  - eng
PT  - Editorial
PT  - Comment
DEP - 20120525
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
RN  - 0 (Antineoplastic Agents, Alkylating)
SB  - IM
CON - Hum Reprod. 2010 Oct;25(10):2489-95. PMID: 20663793
CON - Hum Reprod. 2011 Jun;26(6):1384-8. PMID: 21441542
MH  - Anemia, Sickle Cell/*therapy
MH  - Antineoplastic Agents, Alkylating/*adverse effects
MH  - Female
MH  - Humans
MH  - Ovary/*physiology/*transplantation
MH  - Pregnancy
EDAT- 2012/05/29 06:00
MHDA- 2012/11/14 06:00
CRDT- 2012/05/29 06:00
PHST- 2012/05/29 06:00 [entrez]
PHST- 2012/05/29 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
AID - des167 [pii]
AID - 10.1093/humrep/des167 [doi]
PST - ppublish
SO  - Hum Reprod. 2012 Jul;27(7):1881. doi: 10.1093/humrep/des167. Epub 2012 May 25.


PMID- 22634245
OWN - NLM
STAT- MEDLINE
DCOM- 20121218
LR  - 20120718
IS  - 1096-0295 (Electronic)
IS  - 0273-2300 (Linking)
VI  - 63
IP  - 3
DP  - 2012 Aug
TI  - Challenges and opportunities for the implementation of the Three Rs in Canadian
      vaccine quality control.
PG  - 418-25
LID - 10.1016/j.yrtph.2012.05.006 [doi]
AB  - A case-study approach was used to identify opportunities and challenges to the
      implementation of the Three Rs in vaccine testing in Canada. Data was obtained
      through interviews with 16 Canadian stakeholders involved in the production,
      testing and evaluation of vaccines. Participants identified inconsistent
      regulatory testing requirements, the lack of biological functionality of some in 
      vitro methods, the benchmarking of in vitro against in vivo assays, and high
      caution towards method changes as major challenges to implementation.
      Opportunities to implementation were identified as the desire for and steps taken
      towards harmonization of test methods between countries, collaborations on new
      method development, the poor performance of traditional animal methods, the
      domino effect of one regulatory authority accepting a method after another, and
      stakeholder concerns for the ethical care and use of animals used in vaccine
      testing. These results suggest that industry and the Canadian government are open
      to implementing the Three Rs in vaccine quality control, but methods adopted must
      be reliable and biologically relevant. Improving the harmonization of regulatory 
      requirements will assist in furthering the implementation of alternative methods.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Long, Mara E
AU  - Long ME
AD  - Canadian Council on Animal Care, 1510-130 Albert Street, Ottawa, Ontario, Canada 
      K1P 5G4. mara.elizabeth1@gmail.com
FAU - Griffin, Gilly
AU  - Griffin G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120523
PL  - Netherlands
TA  - Regul Toxicol Pharmacol
JT  - Regulatory toxicology and pharmacology : RTP
JID - 8214983
RN  - 0 (Diphtheria-Tetanus Vaccine)
RN  - 0 (Pertussis Vaccine)
RN  - 0 (Vaccines, Acellular)
SB  - IM
MH  - *Animal Testing Alternatives
MH  - Canada
MH  - *Diphtheria-Tetanus Vaccine
MH  - Humans
MH  - *Pertussis Vaccine
MH  - *Quality Control
MH  - Vaccines, Acellular
EDAT- 2012/05/29 06:00
MHDA- 2012/12/19 06:00
CRDT- 2012/05/29 06:00
PHST- 2012/03/06 00:00 [received]
PHST- 2012/05/09 00:00 [revised]
PHST- 2012/05/10 00:00 [accepted]
PHST- 2012/05/29 06:00 [entrez]
PHST- 2012/05/29 06:00 [pubmed]
PHST- 2012/12/19 06:00 [medline]
AID - S0273-2300(12)00087-6 [pii]
AID - 10.1016/j.yrtph.2012.05.006 [doi]
PST - ppublish
SO  - Regul Toxicol Pharmacol. 2012 Aug;63(3):418-25. doi: 10.1016/j.yrtph.2012.05.006.
      Epub 2012 May 23.


PMID- 22634061
OWN - NLM
STAT- MEDLINE
DCOM- 20130116
LR  - 20191210
IS  - 1873-5223 (Electronic)
IS  - 1471-5953 (Linking)
VI  - 12
IP  - 6
DP  - 2012 Nov
TI  - Collaboration with service users to develop reusable learning objects: the ROOT
      to success.
PG  - 352-5
LID - 10.1016/j.nepr.2012.04.005 [doi]
LID - S1471-5953(12)00084-4 [pii]
AB  - The involvement of service users in the education of health workers is seen as an
      important component within the curriculum. It is thought to facilitate the
      students into developing a deeper understanding around the real lives of their
      patients, and therefore ensuring their care is more person centred. The subject
      area focused upon was developing students' awareness of the needs of people with 
      a learning disability. Recent incidents in the press have highlighted examples of
      poor quality care and a lack of understanding by health and social care
      professionals in regard to their needs. This article highlights a number of key
      issues which must be considered when involving service users, namely consent,
      ethical practice and collaboration. This article will describe the participation 
      of service users in the development of reusable learning objects (RLO's) and make
      recommendations on the optimum way to undertake such an activity. From this
      process a framework has been developed, described as the ROOT to success. The
      ROOT element of the structure relates to Relationship, Organization, Outcome and 
      Team.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Beadle, Mary
AU  - Beadle M
AD  - The University of Hull, Hull, United Kingdom. M.L.Beadle@hull.ac.uk
FAU - Needham, Yvonne
AU  - Needham Y
FAU - Dearing, Mary
AU  - Dearing M
LA  - eng
PT  - Journal Article
DEP - 20120526
PL  - Scotland
TA  - Nurse Educ Pract
JT  - Nurse education in practice
JID - 101090848
SB  - IM
MH  - *Cooperative Behavior
MH  - *Drama
MH  - Education, Nursing/*methods
MH  - Humans
MH  - Learning
MH  - Learning Disabilities/*nursing
MH  - Nursing Education Research
MH  - Nursing Evaluation Research
MH  - Nursing Methodology Research
MH  - *Patient Participation
MH  - Students, Nursing/psychology
EDAT- 2012/05/29 06:00
MHDA- 2013/01/17 06:00
CRDT- 2012/05/29 06:00
PHST- 2011/09/01 00:00 [received]
PHST- 2012/04/05 00:00 [revised]
PHST- 2012/04/21 00:00 [accepted]
PHST- 2012/05/29 06:00 [entrez]
PHST- 2012/05/29 06:00 [pubmed]
PHST- 2013/01/17 06:00 [medline]
AID - S1471-5953(12)00084-4 [pii]
AID - 10.1016/j.nepr.2012.04.005 [doi]
PST - ppublish
SO  - Nurse Educ Pract. 2012 Nov;12(6):352-5. doi: 10.1016/j.nepr.2012.04.005. Epub
      2012 May 26.


PMID- 22633365
OWN - NLM
STAT- MEDLINE
DCOM- 20130306
LR  - 20211122
IS  - 1873-7560 (Electronic)
IS  - 0302-2838 (Linking)
VI  - 62
IP  - 5
DP  - 2012 Nov
TI  - Biochemical recurrence after robot-assisted radical prostatectomy in a European
      single-centre cohort with a minimum follow-up time of 5 years.
PG  - 768-74
LID - 10.1016/j.eururo.2012.05.024 [doi]
LID - S0302-2838(12)00600-8 [pii]
AB  - BACKGROUND: Robot-assisted radical prostatectomy (RARP) is an increasingly
      commonly used surgical treatment option for prostate cancer (PCa); however, its
      longer-term oncologic results remain uncertain. OBJECTIVE: To report biochemical 
      recurrence-free survival (BRFS) outcomes for men who underwent RARP >/=5 yr ago
      at a single European centre. DESIGN, SETTING, AND PARTICIPANTS: A total of 944
      patients underwent RARP as monotherapy for PCa from January 2002 to December 2006
      at Karolinska University Hospital, Stockholm, Sweden. Standard clinicopathologic 
      variables were recorded and entered into a secure, ethics-approved database made 
      up of those men with registered domiciles in Stockholm. The median follow-up time
      was 6.3 yr (interquartile range: 5.6-7.2). OUTCOME MEASUREMENTS AND STATISTICAL
      ANALYSIS: The outcome of this study was biochemical recurrence (BCR), defined as 
      a confirmed prostate-specific antigen (PSA) of >/=0.2 ng/ml. Kaplan-Meier
      survival plots with log-rank tests, as well as Cox univariable and multivariable 
      regression analyses, were used to determine BRFS estimates and determine
      predictors of PSA relapse, respectively. RESULTS AND LIMITATIONS: The BRFS for
      the entire cohort at median follow-up was 84.8% (95% confidence interval [CI],
      82.2-87.1); estimates at 5, 7, and 9 yr were 87.1% (95% CI, 84.8-89.2), 84.5%
      (95% CI, 81.8-86.8), and 82.6% (95% CI, 79.0-85.6), respectively. Nine and 19
      patients died of PCa and other causes, respectively, giving end-of-follow-up
      Kaplan-Meier survival estimates of 98.0% (95% CI, 95.5-99.1) and 94.1% (95% CI,
      90.4-96.4), respectively. Preoperative PSA >10, postoperative Gleason sum >/=4 + 
      3, pathologic T3 disease, positive surgical margin status, and lower surgeon
      volume were associated with increased risk of BCR on multivariable analysis. This
      study is limited by a lack of nodal status and tumour volume, which may have
      confounded our findings. CONCLUSIONS: This case series from a single,
      high-volume, European centre demonstrates that RARP has satisfactory medium-term 
      BRFS. Further follow-up is necessary to determine how this finding will translate
      into cancer-specific and overall survival outcomes.
CI  - Copyright (c) 2012 European Association of Urology. Published by Elsevier B.V.
      All rights reserved.
FAU - Sooriakumaran, Prasanna
AU  - Sooriakumaran P
AD  - Department of Urology, Karolinska University Hospital, Stockholm, Sweden.
FAU - Haendler, Leif
AU  - Haendler L
FAU - Nyberg, Tommy
AU  - Nyberg T
FAU - Gronberg, Henrik
AU  - Gronberg H
FAU - Nilsson, Andreas
AU  - Nilsson A
FAU - Carlsson, Stefan
AU  - Carlsson S
FAU - Hosseini, Abolfazl
AU  - Hosseini A
FAU - Adding, Christofer
AU  - Adding C
FAU - Jonsson, Martin
AU  - Jonsson M
FAU - Ploumidis, Achilles
AU  - Ploumidis A
FAU - Egevad, Lars
AU  - Egevad L
FAU - Steineck, Gunnar
AU  - Steineck G
FAU - Wiklund, Peter
AU  - Wiklund P
LA  - eng
PT  - Journal Article
DEP - 20120518
PL  - Switzerland
TA  - Eur Urol
JT  - European urology
JID - 7512719
RN  - EC 3.4.21.- (KLK3 protein, human)
RN  - EC 3.4.21.- (Kallikreins)
RN  - EC 3.4.21.77 (Prostate-Specific Antigen)
SB  - IM
CIN - Eur Urol. 2012 Nov;62(5):775-6; discussion 777-8. PMID: 22790290
MH  - Aged
MH  - Confounding Factors, Epidemiologic
MH  - Disease-Free Survival
MH  - Follow-Up Studies
MH  - Hospitals, University
MH  - Humans
MH  - Kallikreins/*blood
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Neoplasm Grading
MH  - Neoplasm Staging
MH  - Proportional Hazards Models
MH  - Prostate-Specific Antigen/*blood
MH  - Prostatectomy/adverse effects/*methods/mortality
MH  - Prostatic Neoplasms/blood/mortality/pathology/*surgery
MH  - Recurrence
MH  - Risk Assessment
MH  - Risk Factors
MH  - *Robotics
MH  - *Surgery, Computer-Assisted/adverse effects/mortality
MH  - Sweden
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2012/05/29 06:00
MHDA- 2013/03/07 06:00
CRDT- 2012/05/29 06:00
PHST- 2012/03/07 00:00 [received]
PHST- 2012/05/09 00:00 [accepted]
PHST- 2012/05/29 06:00 [entrez]
PHST- 2012/05/29 06:00 [pubmed]
PHST- 2013/03/07 06:00 [medline]
AID - S0302-2838(12)00600-8 [pii]
AID - 10.1016/j.eururo.2012.05.024 [doi]
PST - ppublish
SO  - Eur Urol. 2012 Nov;62(5):768-74. doi: 10.1016/j.eururo.2012.05.024. Epub 2012 May
      18.


PMID- 22633081
OWN - NLM
STAT- MEDLINE
DCOM- 20120816
LR  - 20161125
IS  - 1476-5616 (Electronic)
IS  - 0033-3506 (Linking)
VI  - 126
IP  - 6
DP  - 2012 Jun
TI  - Continuing professional development for public health: an andragogical approach.
PG  - 541-5
LID - 10.1016/j.puhe.2012.01.032 [doi]
AB  - The UK professional body for public health, the Faculty of Public Health (FPH),
      has a well-established approach towards continuing professional development (CPD)
      for its members and fellows. The FPH approach, initially designed for public
      health physicians, has evolved to meet CPD requirements of a workforce beyond
      that of public health medicine to what is now a multiprofessional public health
      workforce. Despite over 20 years of CPD activity in the field of public health,
      limited literature examines the underlying theoretical principles, or proposes
      the most effective approach to adopt. Public health CPD is a mandatory
      requirement for ongoing practice in many professional groups; it is therefore
      timely to examine theoretical principles and to propose the adoption of an
      andragogical approach to underpin CPD for all disciplines in public health. This 
      paper concludes that adopting an andragogical approach to public health CPD,
      supported with critical reflective practice and undertaken in an ethical and
      moral framework, will equip practitioners to be ready to question practice,
      implement innovation and progress, and meet the challenges of a multiprofessional
      public health service.
CI  - Copyright (c) 2012 The Royal Society for Public Health. Published by Elsevier
      Ltd. All rights reserved.
FAU - Bennetts, C
AU  - Bennetts C
AD  - Graduate School of Education, College of Social Sciences and International
      Studies, University of Exeter, Exeter, UK.
FAU - Elliston, K
AU  - Elliston K
FAU - Maconachie, M
AU  - Maconachie M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120525
PL  - Netherlands
TA  - Public Health
JT  - Public health
JID - 0376507
SB  - IM
MH  - *Education, Continuing
MH  - Education, Public Health Professional/*organization & administration
MH  - *Learning
MH  - Models, Educational
MH  - United Kingdom
EDAT- 2012/05/29 06:00
MHDA- 2012/08/17 06:00
CRDT- 2012/05/29 06:00
PHST- 2010/11/02 00:00 [received]
PHST- 2011/12/06 00:00 [revised]
PHST- 2012/01/25 00:00 [accepted]
PHST- 2012/05/29 06:00 [entrez]
PHST- 2012/05/29 06:00 [pubmed]
PHST- 2012/08/17 06:00 [medline]
AID - S0033-3506(12)00048-0 [pii]
AID - 10.1016/j.puhe.2012.01.032 [doi]
PST - ppublish
SO  - Public Health. 2012 Jun;126(6):541-5. doi: 10.1016/j.puhe.2012.01.032. Epub 2012 
      May 25.


PMID- 22633066
OWN - NLM
STAT- MEDLINE
DCOM- 20140403
LR  - 20220409
IS  - 1532-2793 (Electronic)
IS  - 0260-6917 (Linking)
VI  - 33
IP  - 5
DP  - 2013 May
TI  - Evaluation of a multiple-mini-interview protocol used as a selection tool for
      entry to an undergraduate nursing programme.
PG  - 465-9
LID - 10.1016/j.nedt.2012.04.023 [doi]
LID - S0260-6917(12)00129-3 [pii]
AB  - Whilst an individual's cognitive skills are essential for academic progress, the 
      possession of non-cognitive skills, such as empathy and ethical judgement are
      attributes required and valued in those applying to join healthcare programmes
      and by the profession itself. Doubts have been expressed, however, whether final 
      selection using traditional interviewing methods serve adequately to reveal these
      key competencies. Kingston University and St George's University of London,
      therefore, have employed the Multiple-Mini-Interview (MMI) system for those
      applying to their BSc Nursing Programme. The MMI comprises a series of interview 
      'stations' where candidates respond to scenarios and are assessed on their
      display of required skills/competences. 890 candidates and 82 interviewers
      completed a short questionnaire to gauge their reaction to the concept. There
      were positive responses from candidates with 65% replying that it was "a better
      experience" compared with traditional interviews. Unsolicited comment was
      generally found to refer to restrictions on opportunities to express enthusiasm
      for nursing. Interviewers likewise responded positively with 71% noting "a better
      experience." Unsolicited feedback indicated that some would have preferred to
      have had greater opportunity to discuss nursing issues, with their interviewees. 
      It has been agreed that the MMI system of interviewing will be retained and
      further work will include the tracking of students through and into the
      workplace.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Perkins, Andrew
AU  - Perkins A
AD  - Faculty of Health and Social Care Sciences, Kingston University and St George's
      University of London, Kingston Hill, Kingston upon Thames, KT2 7LB, United
      Kingdom. a.perkins@sgul.kingston.ac.uk
FAU - Burton, Louise
AU  - Burton L
FAU - Dray, Beattie
AU  - Dray B
FAU - Elcock, Karen
AU  - Elcock K
LA  - eng
PT  - Journal Article
DEP - 20120524
PL  - Scotland
TA  - Nurse Educ Today
JT  - Nurse education today
JID - 8511379
MH  - *Attitude
MH  - *Education, Nursing, Baccalaureate
MH  - Humans
MH  - Interviews as Topic/*methods
MH  - London
MH  - Reproducibility of Results
MH  - *School Admission Criteria
EDAT- 2012/05/29 06:00
MHDA- 2014/04/04 06:00
CRDT- 2012/05/29 06:00
PHST- 2011/12/13 00:00 [received]
PHST- 2012/03/06 00:00 [revised]
PHST- 2012/04/30 00:00 [accepted]
PHST- 2012/05/29 06:00 [entrez]
PHST- 2012/05/29 06:00 [pubmed]
PHST- 2014/04/04 06:00 [medline]
AID - S0260-6917(12)00129-3 [pii]
AID - 10.1016/j.nedt.2012.04.023 [doi]
PST - ppublish
SO  - Nurse Educ Today. 2013 May;33(5):465-9. doi: 10.1016/j.nedt.2012.04.023. Epub
      2012 May 24.


PMID- 22632850
OWN - NLM
STAT- MEDLINE
DCOM- 20140113
LR  - 20200401
IS  - 1527-2966 (Electronic)
IS  - 0099-1767 (Linking)
VI  - 39
IP  - 3
DP  - 2013 May
TI  - Whether to break confidentiality: an ethical dilemma.
PG  - 233-5
LID - 10.1016/j.jen.2012.03.003 [doi]
LID - S0099-1767(12)00107-9 [pii]
FAU - Winters, Nancy
AU  - Winters N
AD  - Adelphi University,School of Nursing, One South Avenue, Garden City, NY 11530,
      USA. nwintersrn@gmail.com
LA  - eng
PT  - Journal Article
DEP - 20120523
PL  - United States
TA  - J Emerg Nurs
JT  - Journal of emergency nursing
JID - 7605913
MH  - Confidentiality/*ethics
MH  - Emergency Nursing/*ethics
MH  - Humans
EDAT- 2012/05/29 06:00
MHDA- 2014/01/15 06:00
CRDT- 2012/05/29 06:00
PHST- 2011/12/22 00:00 [received]
PHST- 2012/02/10 00:00 [revised]
PHST- 2012/03/13 00:00 [accepted]
PHST- 2012/05/29 06:00 [entrez]
PHST- 2012/05/29 06:00 [pubmed]
PHST- 2014/01/15 06:00 [medline]
AID - S0099-1767(12)00107-9 [pii]
AID - 10.1016/j.jen.2012.03.003 [doi]
PST - ppublish
SO  - J Emerg Nurs. 2013 May;39(3):233-5. doi: 10.1016/j.jen.2012.03.003. Epub 2012 May
      23.


PMID- 22632659
OWN - NLM
STAT- MEDLINE
DCOM- 20121022
LR  - 20120528
IS  - 1558-349X (Electronic)
IS  - 1546-1440 (Linking)
VI  - 9
IP  - 6
DP  - 2012 Jun
TI  - The ABR "recalls" conundrum: an ethical quandary.
PG  - 380-3
LID - 10.1016/j.jacr.2012.02.002 [doi]
FAU - Berlin, Leonard
AU  - Berlin L
AD  - Skokie Hospital, Department of Radiology, Skokie, IL 60076, USA. lberlin@live.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Coll Radiol
JT  - Journal of the American College of Radiology : JACR
JID - 101190326
SB  - IM
MH  - Educational Measurement/*standards
MH  - Fraud/*ethics
MH  - Radiology/*ethics/*standards
MH  - Specialty Boards/*ethics
MH  - United States
EDAT- 2012/05/29 06:00
MHDA- 2012/10/23 06:00
CRDT- 2012/05/29 06:00
PHST- 2012/01/25 00:00 [received]
PHST- 2012/02/02 00:00 [accepted]
PHST- 2012/05/29 06:00 [entrez]
PHST- 2012/05/29 06:00 [pubmed]
PHST- 2012/10/23 06:00 [medline]
AID - S1546-1440(12)00063-4 [pii]
AID - 10.1016/j.jacr.2012.02.002 [doi]
PST - ppublish
SO  - J Am Coll Radiol. 2012 Jun;9(6):380-3. doi: 10.1016/j.jacr.2012.02.002.


PMID- 22632615
OWN - NLM
STAT- MEDLINE
DCOM- 20121002
LR  - 20181201
IS  - 1527-5418 (Electronic)
IS  - 0890-8567 (Linking)
VI  - 51
IP  - 6
DP  - 2012 Jun
TI  - Ethics and research with vulnerable children.
PG  - 566-8
LID - 10.1016/j.jaac.2012.04.001 [doi]
FAU - Edelsohn, Gail A
AU  - Edelsohn GA
LA  - eng
PT  - Editorial
PT  - Comment
PL  - United States
TA  - J Am Acad Child Adolesc Psychiatry
JT  - Journal of the American Academy of Child and Adolescent Psychiatry
JID - 8704565
SB  - IM
CON - J Am Acad Child Adolesc Psychiatry. 2012 Jun;51(6):572-81. PMID: 22632617
MH  - *Child Care
MH  - *Child Welfare
MH  - Female
MH  - Humans
MH  - Male
MH  - *Mental Disorders
MH  - *Mental Health Services
EDAT- 2012/05/29 06:00
MHDA- 2012/10/04 06:00
CRDT- 2012/05/29 06:00
PHST- 2012/03/29 00:00 [received]
PHST- 2012/04/02 00:00 [accepted]
PHST- 2012/05/29 06:00 [entrez]
PHST- 2012/05/29 06:00 [pubmed]
PHST- 2012/10/04 06:00 [medline]
AID - S0890-8567(12)00283-3 [pii]
AID - 10.1016/j.jaac.2012.04.001 [doi]
PST - ppublish
SO  - J Am Acad Child Adolesc Psychiatry. 2012 Jun;51(6):566-8. doi:
      10.1016/j.jaac.2012.04.001.


PMID- 22632178
OWN - NLM
STAT- MEDLINE
DCOM- 20130805
LR  - 20130215
IS  - 1365-2648 (Electronic)
IS  - 0309-2402 (Linking)
VI  - 69
IP  - 3
DP  - 2013 Mar
TI  - The relationship between value incongruence and individual and organizational
      well-being outcomes: an exploratory study among Catalan nurses.
PG  - 631-41
LID - 10.1111/j.1365-2648.2012.06045.x [doi]
AB  - AIMS: To report a correlational study of the relations of value incongruence to
      the individual and organizational well-being variables of self-rated health,
      turnover intention, and accident propensity, as mediated by burnout. BACKGROUND: 
      Previous literature found that value incongruence may lessen individual and
      organizational well-being through the psychological mechanism of burnout.
      Empirical investigation is needed to validate these claims. DESIGN: A
      cross-sectional between-cases correlational design was used. METHODS: A survey
      was conducted in one of the largest university hospitals in a large metropolitan 
      city in Spain in the spring of 2009, using a cross-sectional design. A total of
      234 nurses participated in the study. Stepwise regression was used to test the
      direct and mediation relationships. RESULTS: Hypotheses were confirmed for
      certain axes of values and outcome variables. In particular, Economical and
      Ethical value incongruence were found to be correlated with burnout. Economical, 
      Ethical, and Emotional value incongruence were found to be correlated with
      turnover intention. Ethical and Emotional value incongruence were found to be
      correlated with accident propensity. Burnout partially mediated the relationship 
      between Economical and Ethical value incongruence and turnover intention and
      fully mediated the relationship between Ethical value incongruence and accident
      propensity. CONCLUSION: The purported mediation of burnout on the relationship
      between value incongruence and individual and organizational well-being outcomes 
      is valid on certain axes of values and outcome variables. This calls for caution 
      when discussing value incongruence in organizations. Instead of advocating broad 
      organizational culture congruence, we should target specific axes of values.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Bao, Yuanjie
AU  - Bao Y
AD  - ESADE, Future of Work Chair, ESADE Business School, PhD room, Ramon Llull
      University, Barcelona, Spain. yuanjie.bao@esade.edu
FAU - Vedina, Rebekka
AU  - Vedina R
FAU - Moodie, Scott
AU  - Moodie S
FAU - Dolan, Simon
AU  - Dolan S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120527
PL  - England
TA  - J Adv Nurs
JT  - Journal of advanced nursing
JID - 7609811
SB  - IM
MH  - Accidents/statistics & numerical data
MH  - Adult
MH  - Attitude of Health Personnel
MH  - Burnout, Professional/epidemiology/*psychology
MH  - Cross-Sectional Studies
MH  - Female
MH  - *Health Status
MH  - Hospitals, University/*organization & administration
MH  - Humans
MH  - Male
MH  - Nurses/*psychology
MH  - Nursing Staff, Hospital/organization & administration/*psychology
MH  - Organizational Culture
MH  - Personnel Turnover/statistics & numerical data
MH  - Spain/epidemiology
EDAT- 2012/05/29 06:00
MHDA- 2013/08/06 06:00
CRDT- 2012/05/29 06:00
PHST- 2012/05/29 06:00 [entrez]
PHST- 2012/05/29 06:00 [pubmed]
PHST- 2013/08/06 06:00 [medline]
AID - 10.1111/j.1365-2648.2012.06045.x [doi]
PST - ppublish
SO  - J Adv Nurs. 2013 Mar;69(3):631-41. doi: 10.1111/j.1365-2648.2012.06045.x. Epub
      2012 May 27.


PMID- 22631861
OWN - NLM
STAT- MEDLINE
DCOM- 20121018
LR  - 20211021
IS  - 1747-4949 (Electronic)
IS  - 1747-4930 (Linking)
VI  - 7
IP  - 6
DP  - 2012 Aug
TI  - Interventions to increase enrollment in a large multicenter phase 3 trial of
      carotid stenting vs. endarterectomy.
PG  - 447-53
LID - 10.1111/j.1747-4949.2012.00833.x [doi]
AB  - BACKGROUND: Randomized clinical trials often encounter slow enrollment. Failing
      to meet sample size requirements has scientific, financial, and ethical
      implications. AIMS: We report interventions used to accelerate recruitment in a
      large multicenter clinical trial that was not meeting prespecified enrollment
      commitments. METHODS: The Carotid Revascularization Endarterectomy vs. Stenting
      Trial began randomization in December 2000. To accelerate enrollment, multiple
      recruitment tactics were initiated, which included expanding the number of sites,
      hiring a recruitment director (May 2003), broadening eligibility criteria (April 
      2005), branding with a study logo, Web site, and recruitment materials,
      increasing site visits by study leadership, sending e-mails to the site teams
      after every enrollment, distributing electronic newsletters, and implementing
      investigator and coordinator conferences. RESULTS: From December 2000 through May
      2003, 14 sites became active (54 patients randomized), from June 2003 through
      April 2005, 44 sites were added (404 patients randomized), and from May 2005
      through July 2008, 54 sites were added (2044 patients randomized). During these
      time intervals, the number of patients enrolled per site per year was 1.5, 3.6,
      and 5.6. For the single years 2004 to 2008, the mean monthly randomization rates 
      per year were 19.7, 38.1, 56.4, 53.0, and 54.7 (annualized), respectively.
      Enrollment was highest after recruitment tactics were implemented: 677 patients
      in 2006, 636 in 2007, and 657 in 2008 (annualized). The prespecified sample size 
      of 2502 patients, 47% asymptomatic, was accomplished on July 2008. CONCLUSIONS:
      Aggressive recruitment tactics and investment in a full-time recruitment director
      who can lead implementation may be effective in accelerating recruitment in
      multicenter trials.
CI  - (c) 2012 The Authors. International Journal of Stroke (c) 2012 World Stroke
      Organization.
FAU - Longbottom, Mary E
AU  - Longbottom ME
AD  - Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.
FAU - Roberts, Jamie N
AU  - Roberts JN
FAU - Tom, Meelee
AU  - Tom M
FAU - Hughes, Susan E
AU  - Hughes SE
FAU - Howard, Virginia J
AU  - Howard VJ
FAU - Sheffet, Alice J
AU  - Sheffet AJ
FAU - Meschia, James F
AU  - Meschia JF
FAU - Brott, Thomas G
AU  - Brott TG
CN  - CREST Investigators
LA  - eng
GR  - R01 NS038384/NS/NINDS NIH HHS/United States
GR  - R01 NS038384-08/NS/NINDS NIH HHS/United States
GR  - U01 NS038384/NS/NINDS NIH HHS/United States
GR  - R01 NS 038384/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120528
PL  - United States
TA  - Int J Stroke
JT  - International journal of stroke : official journal of the International Stroke
      Society
JID - 101274068
SB  - IM
MH  - Costs and Cost Analysis
MH  - Endarterectomy, Carotid/*statistics & numerical data
MH  - Humans
MH  - *Patient Selection
MH  - Sample Size
MH  - Stents/*statistics & numerical data
MH  - Stroke/economics/prevention & control
PMC - PMC3399984
MID - NIHMS368378
EDAT- 2012/05/29 06:00
MHDA- 2012/10/19 06:00
CRDT- 2012/05/29 06:00
PHST- 2012/05/29 06:00 [entrez]
PHST- 2012/05/29 06:00 [pubmed]
PHST- 2012/10/19 06:00 [medline]
AID - 10.1111/j.1747-4949.2012.00833.x [doi]
PST - ppublish
SO  - Int J Stroke. 2012 Aug;7(6):447-53. doi: 10.1111/j.1747-4949.2012.00833.x. Epub
      2012 May 28.


PMID- 22629853
OWN - NLM
STAT- MEDLINE
DCOM- 20120622
LR  - 20120528
IS  - 0031-2991 (Print)
IS  - 0031-2991 (Linking)
IP  - 1
DP  - 2012 Jan-Mar
TI  - [Theory of transition state between norm and pathology].
PG  - 3-12
AB  - In experiments on animals (rodents, carnivores, primates), using the methodology 
      of situational conditioned reflexes, a model of the transition state between norm
      and pathology of humans has been created. We studied the problems that are not
      available to deal with on a person for technical and ethical reasons. Specific
      features of manifestation of the transition state, its central mechanisms and
      biological role were discovered. We found out bifunctional nature of the
      transition state--biologically positive, protective and biologically negative,
      like the state immediately preceding stable disease. It was established that in
      the ascending evolutionary series the increase in role and complexity of
      mechanisms of the positive component of the transition state occur. This fact can
      be explained by the development of adaptive activity of the brain, responding to 
      the complex informational environment and, in particular, to so called
      "informational triad" (a combination of three factors - the amount of
      information, a factor time and level of motivation). We revealed "asymptomatic"
      phenomena of the transition state and showed its role in the development of
      pathology. A theory of the transition state was formulated as a summation of
      knowledge and hypotheses about the phenomena occurring in the body in response to
      a pathogenic stimulus. We proposed the classification of the transition state as 
      a phenomenon, value of which is corresponding to the rate "norm - illness -
      clinical death", i.e. considering it in the rank of major states of the organism.
FAU - Khanashvili, M M
AU  - Khanashvili MM
LA  - rus
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Russia (Federation)
TA  - Patol Fiziol Eksp Ter
JT  - Patologicheskaia fiziologiia i eksperimental'naia terapiia
JID - 0376421
SB  - IM
MH  - Animals
MH  - *Disease Models, Animal
MH  - Humans
MH  - *Models, Biological
EDAT- 2012/05/29 06:00
MHDA- 2012/06/23 06:00
CRDT- 2012/05/29 06:00
PHST- 2012/05/29 06:00 [entrez]
PHST- 2012/05/29 06:00 [pubmed]
PHST- 2012/06/23 06:00 [medline]
PST - ppublish
SO  - Patol Fiziol Eksp Ter. 2012 Jan-Mar;(1):3-12.


PMID- 22629595
OWN - NLM
STAT- MEDLINE
DCOM- 20120823
LR  - 20190911
IS  - 1881-4883 (Electronic)
IS  - 0369-4305 (Linking)
VI  - 68
IP  - 4
DP  - 2012
TI  - [Ethics for being a radiological technologist and/or a researcher].
PG  - 4_I
FAU - Shiraishi, Junji
AU  - Shiraishi J
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Nihon Hoshasen Gijutsu Gakkai Zasshi
JT  - Nihon Hoshasen Gijutsu Gakkai zasshi
JID - 7505722
SB  - IM
MH  - *Ethics, Research
MH  - *Technology, Radiologic
EDAT- 2012/05/29 06:00
MHDA- 2012/08/24 06:00
CRDT- 2012/05/29 06:00
PHST- 2012/05/29 06:00 [entrez]
PHST- 2012/05/29 06:00 [pubmed]
PHST- 2012/08/24 06:00 [medline]
AID - 10.6009/jjrt.2012_jsrt_68.4.4_i [doi]
PST - ppublish
SO  - Nihon Hoshasen Gijutsu Gakkai Zasshi. 2012;68(4):4_I. doi:
      10.6009/jjrt.2012_jsrt_68.4.4_i.


PMID- 22629080
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 0976-5018 (Electronic)
IS  - 0976-500X (Linking)
VI  - 3
IP  - 2
DP  - 2012 Apr
TI  - Clinical trial ethics in India: One step forward, two steps back.
PG  - 95-7
LID - 10.4103/0976-500X.95501 [doi]
FAU - Bhan, Anant
AU  - Bhan A
AD  - Researcher, Bioethics and Global Health, Pune, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Pharmacol Pharmacother
JT  - Journal of pharmacology & pharmacotherapeutics
JID - 101552113
PMC - PMC3356974
EDAT- 2012/05/26 06:00
MHDA- 2012/05/26 06:01
CRDT- 2012/05/26 06:00
PHST- 2012/05/26 06:00 [entrez]
PHST- 2012/05/26 06:00 [pubmed]
PHST- 2012/05/26 06:01 [medline]
AID - 10.4103/0976-500X.95501 [doi]
AID - JPP-3-95 [pii]
PST - ppublish
SO  - J Pharmacol Pharmacother. 2012 Apr;3(2):95-7. doi: 10.4103/0976-500X.95501.


PMID- 22629000
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20220311
IS  - 0974-7834 (Electronic)
IS  - 0974-7796 (Linking)
VI  - 4
IP  - 2
DP  - 2012 May
TI  - Introducing medical humanities in the medical curriculum in Saudi Arabia: A
      pedagogical experiment.
PG  - 73-9
LID - 10.4103/0974-7796.95549 [doi]
AB  - In a marked shift from the modern positivist materialist philosophy that
      influenced medical education for more than a century, Western medical educators
      are now beginning to realize the significance of the spiritual element of human
      nature. Consensus is currently building up in Europe and North America on the
      need to give more emphasis to the study of humanities disciplines such as history
      of medicine, ethics, religion, philosophy, medically related poetry, literature, 
      arts and medical sociology in medical colleges with the aim of allowing graduates
      to reach to the heart of human learning about meaning of life and death and to
      become kinder, more reflective practitioners. The medicine taught and practiced
      during the Islamic civilization era was a vivid example of the unity of the two
      components of medical knowledge: natural sciences and humanities. It was also a
      brilliant illustration of medical ethics driven by a divine moral code. This
      historical fact formed the foundation for the three medical humanities courses
      presented in this article reporting a pedagogical experiment in preparation for
      starting a humanities program in Alfaisal University Medical College in Riyadh.
      In a series of lectures alternating with interactive sessions, active learning
      strategies were employed in teaching a course on history of medicine during the
      Islamic era and another on Islamic medical ethics. Furthermore, a third course on
      medically relevant Arabic poetry was designed and prepared in a similar way. The 
      end-of-the-course feedback comments reflected effectiveness of the courses and
      highlighted the importance of employing student-centered learning techniques in
      order to motivate medical students to become critical thinkers, problem solvers, 
      life-long learners and self-learners.
FAU - Abdel-Halim, Rabie E
AU  - Abdel-Halim RE
AD  - Emeritus Professor of Urology, King Saud University Medical College, Riyadh,
      Formerly Visiting Professor History of Medicine and Medical Ethics, Alfaisal
      University Medical College, Riyadh, Saudi Arabia.
FAU - Alkattan, Khaled M
AU  - Alkattan KM
LA  - eng
PT  - Journal Article
PL  - India
TA  - Urol Ann
JT  - Urology annals
JID - 101510823
PMC - PMC3355704
OTO - NOTNLM
OT  - Arabic medical poetry
OT  - History of medicine
OT  - Islamic civilization
OT  - Islamic medical ethics
OT  - Islamic studies
OT  - Medical education
OT  - Modern medicine
OT  - Post-modern medicine
OT  - active-learning strategies
OT  - critical-thinking skills
EDAT- 2012/05/26 06:00
MHDA- 2012/05/26 06:01
CRDT- 2012/05/26 06:00
PHST- 2012/01/21 00:00 [received]
PHST- 2012/03/15 00:00 [accepted]
PHST- 2012/05/26 06:00 [entrez]
PHST- 2012/05/26 06:00 [pubmed]
PHST- 2012/05/26 06:01 [medline]
AID - 10.4103/0974-7796.95549 [doi]
AID - UA-4-73 [pii]
PST - ppublish
SO  - Urol Ann. 2012 May;4(2):73-9. doi: 10.4103/0974-7796.95549.


PMID- 22627721
OWN - NLM
STAT- MEDLINE
DCOM- 20120627
LR  - 20151119
IS  - 0093-0334 (Print)
IS  - 0093-0334 (Linking)
VI  - 42
IP  - 3
DP  - 2012 May-Jun
TI  - Clinical use of placebos: still the physician's prerogative?
PG  - 29-37
LID - 10.1002/hast.33 [doi]
AB  - The American Medical Association's Code of Ethics holds that if a physician
      believes a treatment to be a placebo, then the patient should be informed of that
      belief, and the treatment should not be prescribed unless the patient agrees to
      its use. But this is not clearly the best way either to protect patients or to
      benefit them. The physician's own beliefs should not be decisive.
FAU - Barnhill, Anne
AU  - Barnhill A
LA  - eng
PT  - Journal Article
DEP - 20120423
PL  - United States
TA  - Hastings Cent Rep
JT  - The Hastings Center report
JID - 0410447
RN  - 0 (Placebos)
SB  - IM
CIN - Hastings Cent Rep. 2012 May-Jun;42(3):3. PMID: 22627713
MH  - American Medical Association
MH  - Ethics, Medical
MH  - Humans
MH  - Patients/*psychology
MH  - *Personal Autonomy
MH  - Physician-Patient Relations/*ethics
MH  - Physicians/*ethics
MH  - *Placebos/therapeutic use
MH  - Practice Patterns, Physicians'/*ethics
MH  - Psychophysiology
MH  - *Trust
MH  - United States
EDAT- 2012/05/26 06:00
MHDA- 2012/06/28 06:00
CRDT- 2012/05/26 06:00
PHST- 2012/05/26 06:00 [entrez]
PHST- 2012/05/26 06:00 [pubmed]
PHST- 2012/06/28 06:00 [medline]
AID - 10.1002/hast.33 [doi]
PST - ppublish
SO  - Hastings Cent Rep. 2012 May-Jun;42(3):29-37. doi: 10.1002/hast.33. Epub 2012 Apr 
      23.


PMID- 22627087
OWN - NLM
STAT- MEDLINE
DCOM- 20121029
LR  - 20120611
IS  - 1873-6386 (Electronic)
IS  - 0160-2527 (Linking)
VI  - 35
IP  - 4
DP  - 2012 Jul-Aug
TI  - An ethical framework for assessments of criminal responsibility: applying Susan
      Wolf's account of sanity to forensic psychiatry.
PG  - 298-304
LID - 10.1016/j.ijlp.2012.04.011 [doi]
AB  - Within the context of an ethical theory of responsibility, Susan Wolf has argued 
      that people can only be considered fully responsible for their actions when they 
      are sane. In this paper I explore the possibility of applying her ethical account
      of sanity and responsibility to forensic assessments of criminal responsibility. 
      I argue that after some substantial revisions her account can be helpful in order
      to arrive at an ethics-based conceptual framework for forensic psychiatric
      assessments within the context of an insanity defense.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Meynen, Gerben
AU  - Meynen G
AD  - Tilburg Law School, Tilburg University, Prof. Cobbenhagenlaan 221, 5037 DE
      Tilburg, The Netherlands. g.meynen@uvt.nl
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120522
PL  - Netherlands
TA  - Int J Law Psychiatry
JT  - International journal of law and psychiatry
JID - 7806862
SB  - IM
MH  - Criminal Law
MH  - Forensic Psychiatry/*ethics
MH  - Humans
MH  - *Insanity Defense
MH  - Mental Competency/*legislation & jurisprudence
MH  - Moral Development
EDAT- 2012/05/26 06:00
MHDA- 2012/10/30 06:00
CRDT- 2012/05/26 06:00
PHST- 2012/05/26 06:00 [entrez]
PHST- 2012/05/26 06:00 [pubmed]
PHST- 2012/10/30 06:00 [medline]
AID - S0160-2527(12)00053-2 [pii]
AID - 10.1016/j.ijlp.2012.04.011 [doi]
PST - ppublish
SO  - Int J Law Psychiatry. 2012 Jul-Aug;35(4):298-304. doi:
      10.1016/j.ijlp.2012.04.011. Epub 2012 May 22.


PMID- 22626914
OWN - NLM
STAT- MEDLINE
DCOM- 20121001
LR  - 20211021
IS  - 1879-1190 (Electronic)
IS  - 1072-7515 (Linking)
VI  - 215
IP  - 2
DP  - 2012 Aug
TI  - John J Conley Lecture on Ethics and Philosophy. Health care reform: ethical
      foundations, policy, and law.
PG  - 286-96
LID - 10.1016/j.jamcollsurg.2012.03.019 [doi]
FAU - Sade, Robert M
AU  - Sade RM
AD  - Department of Surgery, the Institute of Human Values in Health Care, Medical
      University of South Carolina, Charleston, SC 29425, USA. sader@musc.edu
LA  - eng
GR  - UL1 RR029882/RR/NCRR NIH HHS/United States
GR  - UL1RR029882/RR/NCRR NIH HHS/United States
PT  - Lecture
PT  - Research Support, N.I.H., Extramural
DEP - 20120523
PL  - United States
TA  - J Am Coll Surg
JT  - Journal of the American College of Surgeons
JID - 9431305
SB  - IM
MH  - Capitalism
MH  - Freedom
MH  - Government Regulation
MH  - *Health Care Reform/economics/ethics/legislation & jurisprudence
MH  - Healthcare Disparities/ethics
MH  - Humans
MH  - National Health Insurance, United States/economics/ethics/legislation &
      jurisprudence
MH  - Patient Protection and Affordable Care Act
MH  - Patient Rights/ethics/legislation & jurisprudence
MH  - United States
PMC - PMC4486288
MID - NIHMS702696
EDAT- 2012/05/26 06:00
MHDA- 2012/10/02 06:00
CRDT- 2012/05/26 06:00
PHST- 2012/02/28 00:00 [received]
PHST- 2012/03/06 00:00 [accepted]
PHST- 2012/05/26 06:00 [entrez]
PHST- 2012/05/26 06:00 [pubmed]
PHST- 2012/10/02 06:00 [medline]
AID - S1072-7515(12)00266-9 [pii]
AID - 10.1016/j.jamcollsurg.2012.03.019 [doi]
PST - ppublish
SO  - J Am Coll Surg. 2012 Aug;215(2):286-96. doi: 10.1016/j.jamcollsurg.2012.03.019.
      Epub 2012 May 23.


PMID- 22625656
OWN - NLM
STAT- MEDLINE
DCOM- 20121112
LR  - 20220410
IS  - 1365-229X (Electronic)
IS  - 0009-9260 (Linking)
VI  - 67
IP  - 10
DP  - 2012 Oct
TI  - A comparison of the accuracy of film-screen mammography, full-field digital
      mammography, and digital breast tomosynthesis.
PG  - 976-81
LID - 10.1016/j.crad.2012.03.009 [doi]
AB  - AIM: To measure the change in diagnostic accuracy of conventional film-screen
      mammography and full-field digital mammography (FFDM) with the addition of
      digital breast tomosynthesis (DBT) in women recalled for assessment following
      routine screening. MATERIALS AND METHODS: Ethics approval for the study was
      granted. Women recalled for assessment following routine screening with
      screen-film mammography were invited to participate. Participants underwent
      bilateral, two-view FFDM and two-view DBT. Readers scored each lesion separately 
      for probability of malignancy on screen-film mammography, FFDM, and then DBT. The
      scores were compared with the presence or absence of malignancy based on the
      final histopathology outcome. RESULTS: Seven hundred and thirty-eight women
      participated (93.2% recruitment rate). Following assessment 204 (26.8%) were
      diagnosed as malignant (147 invasive and 57 in-situ tumours), 286 (37.68%) as
      benign, and 269 (35.4%) as normal. The diagnostic accuracy was evaluated by using
      receiving operating characteristic (ROC) and measurement of area under the curve 
      (AUC). The AUC values demonstrated a significant (p = 0.0001) improvement in the 
      diagnostic accuracy with the addition of DBT combined with FFDM and film-screen
      mammography (AUC = 0.9671) when compared to FFDM plus film-screen mammography
      (AUC = 0.8949) and film-screen mammography alone (AUC = 0.7882). The effect was
      significantly greater for soft-tissue lesions [AUC was 0.9905 with the addition
      of DBT and AUC was 0.9201 for FFDM with film-screen mammography combined (p =
      0.0001)] compared to microcalcification [with the addition of DBT (AUC = 0.7920) 
      and for FFDM with film-screen mammography combined (AUC = 0.7843; p = 0.3182)].
      CONCLUSION: The addition of DBT increases the accuracy of mammography compared to
      FFDM and film-screen mammography combined and film-screen mammography alone in
      the assessment of screen-detected soft-tissue mammographic abnormalities.
CI  - Copyright (c) 2012 The Royal College of Radiologists. Published by Elsevier Ltd. 
      All rights reserved.
FAU - Michell, M J
AU  - Michell MJ
AD  - Breast Radiology, King's College Hospital, London, UK. michael.michell@nhs.net
FAU - Iqbal, A
AU  - Iqbal A
FAU - Wasan, R K
AU  - Wasan RK
FAU - Evans, D R
AU  - Evans DR
FAU - Peacock, C
AU  - Peacock C
FAU - Lawinski, C P
AU  - Lawinski CP
FAU - Douiri, A
AU  - Douiri A
FAU - Wilson, R
AU  - Wilson R
FAU - Whelehan, P
AU  - Whelehan P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120523
PL  - England
TA  - Clin Radiol
JT  - Clinical radiology
JID - 1306016
SB  - IM
MH  - Adult
MH  - Breast Neoplasms/*diagnostic imaging/epidemiology
MH  - Female
MH  - Humans
MH  - Mammography/*statistics & numerical data
MH  - Middle Aged
MH  - Observer Variation
MH  - Prevalence
MH  - Radiographic Image Enhancement/*methods
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - United Kingdom/epidemiology
MH  - X-Ray Film/*statistics & numerical data
MH  - Young Adult
EDAT- 2012/05/26 06:00
MHDA- 2012/11/13 06:00
CRDT- 2012/05/26 06:00
PHST- 2011/10/03 00:00 [received]
PHST- 2012/02/15 00:00 [revised]
PHST- 2012/03/06 00:00 [accepted]
PHST- 2012/05/26 06:00 [entrez]
PHST- 2012/05/26 06:00 [pubmed]
PHST- 2012/11/13 06:00 [medline]
AID - S0009-9260(12)00145-6 [pii]
AID - 10.1016/j.crad.2012.03.009 [doi]
PST - ppublish
SO  - Clin Radiol. 2012 Oct;67(10):976-81. doi: 10.1016/j.crad.2012.03.009. Epub 2012
      May 23.


PMID- 22624768
OWN - NLM
STAT- MEDLINE
DCOM- 20121119
LR  - 20120525
IS  - 1834-7819 (Electronic)
IS  - 0045-0421 (Linking)
VI  - 57
IP  - 2
DP  - 2012 Jun
TI  - Exotic encounters with dental implants: managing complications with unidentified 
      systems.
PG  - 236-42
LID - 10.1111/j.1834-7819.2012.01676.x [doi]
AB  - As the application of dental implants increases worldwide, so is the number of
      technical and biological complications that general dental practitioners will be 
      called to manage, while maintaining implant patients. In addition, the greater
      patient mobility encountered today combined with a growing trend of 'dental
      implant tourism' will very often result in situations where the dentist is
      requested to deal with complications in implants placed elsewhere and which
      sometimes might be of an 'exotic' system one cannot directly recognize. Such a
      situation can pose significant challenges to even experienced clinicians. The
      challenges are not only in the scientific field, but often include professional
      and ethical implications. This case report will discuss strategies for the
      management of implant complications in cases of unidentified implant systems.
      Critical factors in such situations would be the clinician's experience and
      special training, the correct radiographic technique, as well as access to the
      appropriate tools and devices.
CI  - (c) 2012 Australian Dental Association.
FAU - Mattheos, N
AU  - Mattheos N
AD  - School of Dentistry and Oral Health, Griffith University, Gold Coast, Queensland,
      Australia. nikos@mattheos.net
FAU - Janda, M Schittek
AU  - Janda MS
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20120316
PL  - Australia
TA  - Aust Dent J
JT  - Australian dental journal
JID - 0370612
RN  - 0 (Dental Implants)
SB  - IM
MH  - Australia
MH  - Dental Calculus/complications/etiology
MH  - Dental Implants/*adverse effects
MH  - *Dental Restoration Failure
MH  - Humans
MH  - Male
MH  - Medical Tourism
MH  - Middle Aged
MH  - Mucositis/complications/etiology
MH  - Radiography, Dental/methods
MH  - Referral and Consultation
MH  - Stomatitis/complications/etiology
EDAT- 2012/05/26 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/05/26 06:00
PHST- 2012/05/26 06:00 [entrez]
PHST- 2012/05/26 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1111/j.1834-7819.2012.01676.x [doi]
PST - ppublish
SO  - Aust Dent J. 2012 Jun;57(2):236-42. doi: 10.1111/j.1834-7819.2012.01676.x. Epub
      2012 Mar 16.


PMID- 22624697
OWN - NLM
STAT- MEDLINE
DCOM- 20121106
LR  - 20211021
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 13
DP  - 2012 May 24
TI  - Analgesia effect of a fixed nitrous oxide/oxygen mixture on burn dressing pain:
      study protocol for a randomized controlled trial.
PG  - 67
LID - 10.1186/1745-6215-13-67 [doi]
AB  - BACKGROUND: Procedural burn pain is the most intense acute pain and most likely
      type of burn injury pain to be undertreated due to the physician's fear of the
      adverse effect of analgesia and lack of anesthetist present. At our institution, 
      in most of the cases, local burn detersion and debridement were performed at the 
      ward level without any analgesics. This article describes a study designed to
      test the analgesia effect of a fixed nitrous oxide/oxygen mixture on burn
      dressing pain. METHODS/DESIGN: The experiment was carried out in three centers.
      The patients were given a number from 1 to 240. A randomization list was produced
      by a statistician according to our preliminary study. Due to the severity of the 
      pain suffered, ethically it was decided to help as many as possible, so patients 
      given the letters A, B or C were treated using a canister with the appropriate
      letter containing preprepared nitrous oxide/oxygen mixture (NOOM). Those with D
      were given oxygen only, from an identical-looking canister labeled D. Neither
      patients, nor doctors, nor nurses, nor data collector knew what was in each
      canister, thus they were all blind. The nursing officer who implemented the
      intervention handed the doctors envelopes containing the patients' name and
      allocation of A, B, C or D. Thus, patients receiving NOOM or oxygen were in the
      ratio 3:1. Parameters, including pain severity, blood pressure, heart rate,
      digital oxygen saturation and the Chinese version of the burn specific pain
      anxiety scale (C-BSPAS), were taken before, during and after dressing for each
      group. A video and audio record was taken individually for later communication
      coding and outcome analysis. Rescue analgesic was recorded. DISCUSSION: Based on 
      the findings from our previous qualitative study that physician's reluctance to
      order narcotic analgesia is due to its adverse effect and from our pilot
      experiment, this study aims to test the hypothesis that a fixed nitrous
      oxide/oxygen mixture will promote better burn dressing pain alleviation and
      outcomes. Analyses will focus on the effects of the experimental intervention on 
      pain severity during dressing (primary outcomes); physiological parameters,
      C-BSPAS and acceptance of both health care professionals and patients (secondary 
      outcomes). If this model of analgesia for burn pain management implemented by
      nurses proves successful, it could potentially be implemented widely in hospital 
      and prehospital settings and improve patients' satisfaction and quality of life. 
      TRIAL REGISTRATION: (Clinical Trials Identifier: CHICTR-TRC11001690).
FAU - Yuxiang, Li
AU  - Yuxiang L
AD  - Department of Nursing, Changhai Hospital, Second Military Medical University, 168
      Changhai Road, Shanghai 200433, China.
FAU - Lu, Tang
AU  - Lu T
FAU - Jianqiang, Yu
AU  - Jianqiang Y
FAU - Xiuying, Dai
AU  - Xiuying D
FAU - Wanfang, Zhou
AU  - Wanfang Z
FAU - Wannian, Zhang
AU  - Wannian Z
FAU - Xiaoyan, Hu
AU  - Xiaoyan H
FAU - Shichu, Xiao
AU  - Shichu X
FAU - Wen, Ni
AU  - Wen N
FAU - Xiuqiang, Ma
AU  - Xiuqiang M
FAU - Yinsheng, Wu
AU  - Yinsheng W
FAU - Ming, Yao
AU  - Ming Y
FAU - Guoxia, Mu
AU  - Guoxia M
FAU - Guangyi, Wang
AU  - Guangyi W
FAU - Wenjun, Han
AU  - Wenjun H
FAU - Zhaofan, Xia
AU  - Zhaofan X
FAU - Hongtai, Tang
AU  - Hongtai T
FAU - Jijun, Zhao
AU  - Jijun Z
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20120524
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
RN  - 0 (Analgesics)
RN  - K50XQU1029 (Nitrous Oxide)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Administration, Inhalation
MH  - Analgesics/*administration & dosage
MH  - Bandages/*adverse effects
MH  - Burns/complications/psychology/*therapy
MH  - China
MH  - Double-Blind Method
MH  - Humans
MH  - Nitrous Oxide/*administration & dosage
MH  - Oxygen/*administration & dosage
MH  - Pain/diagnosis/etiology/*prevention & control/psychology
MH  - Pain Management/*methods
MH  - Pain Measurement
MH  - *Research Design
MH  - Severity of Illness Index
MH  - Time Factors
MH  - Treatment Outcome
MH  - Video Recording
PMC - PMC3404913
EDAT- 2012/05/26 06:00
MHDA- 2012/11/07 06:00
CRDT- 2012/05/26 06:00
PHST- 2011/12/14 00:00 [received]
PHST- 2012/05/24 00:00 [accepted]
PHST- 2012/05/26 06:00 [entrez]
PHST- 2012/05/26 06:00 [pubmed]
PHST- 2012/11/07 06:00 [medline]
AID - 1745-6215-13-67 [pii]
AID - 10.1186/1745-6215-13-67 [doi]
PST - epublish
SO  - Trials. 2012 May 24;13:67. doi: 10.1186/1745-6215-13-67.


PMID- 22624597
OWN - NLM
STAT- MEDLINE
DCOM- 20130107
LR  - 20211021
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 13
DP  - 2012 May 24
TI  - One and done? Equality of opportunity and repeated access to scarce, indivisible 
      medical resources.
PG  - 11
LID - 10.1186/1472-6939-13-11 [doi]
AB  - BACKGROUND: Existing ethical guidelines recommend that, all else equal, past
      receipt of a medical resource (e.g. a scarce organ) should not be considered in
      current allocation decisions (e.g. a repeat transplantation). DISCUSSION: One
      stated reason for this ethical consensus is that formal theories of ethics and
      justice do not persuasively accept or reject repeated access to the same medical 
      resources. Another is that restricting attention to past receipt of a particular 
      medical resource seems arbitrary: why couldn't one just as well, it is argued,
      consider receipt of other goods such as income or education? In consequence,
      simple allocation by lottery or first-come-first-served without consideration of 
      any past receipt is thought to best afford equal opportunity, conditional on
      equal medical need.There are three issues with this view that need to be
      addressed. First, public views and patient preferences are less ambiguous than
      formal theories of ethics. Empirical work shows strong preferences for fairness
      in health care that have not been taken into account: repeated access to
      resources has been perceived as unfair. Second, while difficult to consider
      receipt of many other prior resources including non-medical resources, this
      should not be used a motive for ignoring the receipt of any and all goods
      including the focal resource in question. Third, when all claimants to a scarce
      resource are equally deserving, then use of random allocation seems warranted.
      However, the converse is not true: mere use of a randomizer does not by itself
      make the merits of all claimants equal. SUMMARY: My conclusion is that not
      ignoring prior receipt of the same medical resource, and prioritizing those who
      have not previously had access to the medical resource in question, may be
      perceived as fairer and more equitable by society.
FAU - Huesch, Marco D
AU  - Huesch MD
AD  - USC Sol Price School of Public Policy, University of Southern California, Los
      Angeles, CA, USA. huesch@usc.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120524
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Guidelines as Topic
MH  - Health Care Rationing/*ethics
MH  - Health Resources/*supply & distribution
MH  - *Health Services Needs and Demand/ethics
MH  - Humans
MH  - Organ Transplantation/ethics
MH  - Reoperation/ethics
MH  - Social Justice/*ethics
MH  - United States
PMC - PMC3467161
EDAT- 2012/05/26 06:00
MHDA- 2013/01/08 06:00
CRDT- 2012/05/26 06:00
PHST- 2011/11/02 00:00 [received]
PHST- 2012/05/03 00:00 [accepted]
PHST- 2012/05/26 06:00 [entrez]
PHST- 2012/05/26 06:00 [pubmed]
PHST- 2013/01/08 06:00 [medline]
AID - 1472-6939-13-11 [pii]
AID - 10.1186/1472-6939-13-11 [doi]
PST - epublish
SO  - BMC Med Ethics. 2012 May 24;13:11. doi: 10.1186/1472-6939-13-11.


PMID- 22624587
OWN - NLM
STAT- MEDLINE
DCOM- 20121227
LR  - 20220210
IS  - 1525-1403 (Electronic)
IS  - 1094-7159 (Linking)
VI  - 15
IP  - 4
DP  - 2012 Jul
TI  - Central thalamic deep brain stimulation to promote recovery from chronic
      posttraumatic minimally conscious state: challenges and opportunities.
PG  - 339-49
LID - 10.1111/j.1525-1403.2012.00458.x [doi]
AB  - BACKGROUND: Central thalamic deep brain stimulation (CT-DBS) may have therapeutic
      potential to improve behavioral functioning in patients with severe traumatic
      brain injury (TBI), but its use remains experimental. Current research suggests
      that the central thalamus plays a critical role in modulating arousal during
      tasks requiring sustained attention, working memory, and motor function. The aim 
      of the current article is to review the methodology used in the CT-DBS protocol
      developed by our group, outline the challenges we encountered and offer
      suggestions for future DBS trials in this population. RATIONAL FOR CT-DBS IN TBI:
      CT-DBS may therefore be able to stimulate these functions by eliciting action
      potentials that excite thalamocortical and thalamostriatal pathways. Because
      patients in chronic minimally conscious state (MCS) have a very low probability
      of regaining functional independence, yet often have significant sparing of
      cortical connectivity, they may represent a particularly appropriate target group
      for CT-DBS. PIlOT STUDY RESULTS: We have conducted a series of single-subject
      studies of CT-DBS in patients with chronic posttraumatic MCS, with 24-month
      follow-up. Outcomes were measured using the Coma Recovery Scale-Revised as well
      as a battery of secondary outcome measures to capture more granular changes.
      Findings from our index case suggest that CT-DBS can significantly increase
      functional communication, motor performance, feeding, and object naming in the
      DBS on state, with performance in some domains remaining above baseline even
      after DBS was turned off. CONCLUSIONS: The use of CT-DBS in patients in MCS,
      however, presents challenges at almost every step, including during surgical
      planning, outcome measurement, and postoperative care. Additionally, given the
      difficulties of obtaining informed consent from patients in MCS and the
      experimental nature of the treatment, a robust, scientifically rooted ethical
      framework is resented for pursuing this line of work.
CI  - (c) 2012 International Neuromodulation Society.
FAU - Giacino, Joseph
AU  - Giacino J
AD  - Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation
      Hospital, Boston, MA 02114, USA. jgiacino@partners.org
FAU - Fins, Joseph J
AU  - Fins JJ
FAU - Machado, Andre
AU  - Machado A
FAU - Schiff, Nicholas D
AU  - Schiff ND
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120524
PL  - United States
TA  - Neuromodulation
JT  - Neuromodulation : journal of the International Neuromodulation Society
JID - 9804159
SB  - IM
MH  - Brain Injuries/complications/*therapy
MH  - Brain Mapping
MH  - Clinical Trials as Topic/ethics
MH  - Deep Brain Stimulation/ethics/instrumentation/*methods
MH  - Electrodes, Implanted
MH  - Humans
MH  - Informed Consent
MH  - Monitoring, Intraoperative
MH  - Neuronavigation
MH  - Neurosurgical Procedures/methods
MH  - Patient Care Planning
MH  - Patient Selection
MH  - Persistent Vegetative State/etiology/*therapy
MH  - Postoperative Care
MH  - Recovery of Function
MH  - Thalamus/*physiology
EDAT- 2012/05/26 06:00
MHDA- 2012/12/28 06:00
CRDT- 2012/05/26 06:00
PHST- 2012/05/26 06:00 [entrez]
PHST- 2012/05/26 06:00 [pubmed]
PHST- 2012/12/28 06:00 [medline]
AID - 10.1111/j.1525-1403.2012.00458.x [doi]
AID - S1094-7159(21)01272-1 [pii]
PST - ppublish
SO  - Neuromodulation. 2012 Jul;15(4):339-49. doi: 10.1111/j.1525-1403.2012.00458.x.
      Epub 2012 May 24.


PMID- 22624541
OWN - NLM
STAT- MEDLINE
DCOM- 20120822
LR  - 20120525
IS  - 1469-2147 (Electronic)
IS  - 0963-1801 (Linking)
VI  - 21
IP  - 3
DP  - 2012 Jul
TI  - Regulating ethics in Australian healthcare research.
PG  - 384-90
LID - 10.1017/S0963180112000102 [doi]
FAU - Cregan, Kate
AU  - Cregan K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Camb Q Healthc Ethics
JT  - Cambridge quarterly of healthcare ethics : CQ : the international journal of
      healthcare ethics committees
JID - 9208482
SB  - IM
MH  - Australia
MH  - Clinical Trials as Topic/ethics
MH  - Delivery of Health Care/*ethics/legislation & jurisprudence
MH  - *Ethics, Research
MH  - Health Services Research/*ethics/legislation & jurisprudence
MH  - Human Experimentation/*ethics/*legislation & jurisprudence
MH  - Humans
EDAT- 2012/05/26 06:00
MHDA- 2012/08/23 06:00
CRDT- 2012/05/26 06:00
PHST- 2012/05/26 06:00 [entrez]
PHST- 2012/05/26 06:00 [pubmed]
PHST- 2012/08/23 06:00 [medline]
AID - S0963180112000102 [pii]
AID - 10.1017/S0963180112000102 [doi]
PST - ppublish
SO  - Camb Q Healthc Ethics. 2012 Jul;21(3):384-90. doi: 10.1017/S0963180112000102.


PMID- 22624534
OWN - NLM
STAT- MEDLINE
DCOM- 20120822
LR  - 20211203
IS  - 1469-2147 (Electronic)
IS  - 0963-1801 (Linking)
VI  - 21
IP  - 3
DP  - 2012 Jul
TI  - Racial/ethnic health disparities and ethics -- the need for a multilevel
      approach.
PG  - 309-19
LID - 10.1017/S0963180112000035 [doi]
FAU - Brody, Howard
AU  - Brody H
FAU - Glenn, Jason E
AU  - Glenn JE
FAU - Hermer, Laura
AU  - Hermer L
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Camb Q Healthc Ethics
JT  - Cambridge quarterly of healthcare ethics : CQ : the international journal of
      healthcare ethics committees
JID - 9208482
SB  - IM
MH  - *Ethnicity
MH  - *Health Care Reform
MH  - *Health Policy/trends
MH  - Health Services Needs and Demand
MH  - *Healthcare Disparities
MH  - Humans
MH  - Social Justice
MH  - United States
EDAT- 2012/05/26 06:00
MHDA- 2012/08/23 06:00
CRDT- 2012/05/26 06:00
PHST- 2012/05/26 06:00 [entrez]
PHST- 2012/05/26 06:00 [pubmed]
PHST- 2012/08/23 06:00 [medline]
AID - S0963180112000035 [pii]
AID - 10.1017/S0963180112000035 [doi]
PST - ppublish
SO  - Camb Q Healthc Ethics. 2012 Jul;21(3):309-19. doi: 10.1017/S0963180112000035.


PMID- 22624533
OWN - NLM
STAT- MEDLINE
DCOM- 20120822
LR  - 20181201
IS  - 1469-2147 (Electronic)
IS  - 0963-1801 (Linking)
VI  - 21
IP  - 3
DP  - 2012 Jul
TI  - The need for continued ethical scrutiny.
PG  - 307
LID - 10.1017/S0963180112000023 [doi]
FAU - Stone, John R
AU  - Stone JR
FAU - Dula, Annette
AU  - Dula A
LA  - eng
PT  - Editorial
PL  - United States
TA  - Camb Q Healthc Ethics
JT  - Cambridge quarterly of healthcare ethics : CQ : the international journal of
      healthcare ethics committees
JID - 9208482
SB  - IM
MH  - *Global Health
MH  - *Healthcare Disparities
MH  - Humans
MH  - Insurance, Health
MH  - *Socioeconomic Factors
MH  - Universal Health Insurance
EDAT- 2012/05/26 06:00
MHDA- 2012/08/23 06:00
CRDT- 2012/05/26 06:00
PHST- 2012/05/26 06:00 [entrez]
PHST- 2012/05/26 06:00 [pubmed]
PHST- 2012/08/23 06:00 [medline]
AID - S0963180112000023 [pii]
AID - 10.1017/S0963180112000023 [doi]
PST - ppublish
SO  - Camb Q Healthc Ethics. 2012 Jul;21(3):307. doi: 10.1017/S0963180112000023.


PMID- 22624237
OWN - NLM
STAT- MEDLINE
DCOM- 20120703
LR  - 20120525
IS  - 0882-1577 (Print)
IS  - 0882-1577 (Linking)
VI  - 93
IP  - 3
DP  - 2012 May-Jun
TI  - Nurturing health care ethicists for the future. Efforts continue.
PG  - 67-9
FAU - Hamel, Ron
AU  - Hamel R
AD  - Catholic Health Association, St Louis, USA. rhamel@chausa.org
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Health Prog
JT  - Health progress (Saint Louis, Mo.)
JID - 8500263
MH  - Catholicism
MH  - *Ethicists
MH  - Humans
MH  - *Mentors
MH  - United States
EDAT- 2012/05/26 06:00
MHDA- 2012/07/04 06:00
CRDT- 2012/05/26 06:00
PHST- 2012/05/26 06:00 [entrez]
PHST- 2012/05/26 06:00 [pubmed]
PHST- 2012/07/04 06:00 [medline]
PST - ppublish
SO  - Health Prog. 2012 May-Jun;93(3):67-9.


PMID- 22624231
OWN - NLM
STAT- MEDLINE
DCOM- 20120703
LR  - 20120525
IS  - 0882-1577 (Print)
IS  - 0882-1577 (Linking)
VI  - 93
IP  - 3
DP  - 2012 May-Jun
TI  - Integrating ethics into the residency model of physician education.
PG  - 34-5
FAU - Repenshek, Mark
AU  - Repenshek M
AD  - Columbia St. Mary's Health System, Milwaukee, USA.
FAU - O'Tool, Erin
AU  - O'Tool E
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Health Prog
JT  - Health progress (Saint Louis, Mo.)
JID - 8500263
MH  - Ethics, Medical/*education
MH  - *Internship and Residency
MH  - Models, Organizational
MH  - Organizational Case Studies
MH  - Systems Integration
MH  - Wisconsin
EDAT- 2012/05/26 06:00
MHDA- 2012/07/04 06:00
CRDT- 2012/05/26 06:00
PHST- 2012/05/26 06:00 [entrez]
PHST- 2012/05/26 06:00 [pubmed]
PHST- 2012/07/04 06:00 [medline]
PST - ppublish
SO  - Health Prog. 2012 May-Jun;93(3):34-5.


PMID- 22624230
OWN - NLM
STAT- MEDLINE
DCOM- 20120703
LR  - 20160712
IS  - 0882-1577 (Print)
IS  - 0882-1577 (Linking)
VI  - 93
IP  - 3
DP  - 2012 May-Jun
TI  - Ethics training for medical interns/residents in the Mercy Health System.
PG  - 30-1
FAU - Clark, Peter A
AU  - Clark PA
AD  - Department of Theology and Religious Studies, Institute of Catholic at St. Joseph
      University, Philadelphia, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Health Prog
JT  - Health progress (Saint Louis, Mo.)
JID - 8500263
MH  - Catholicism
MH  - Ethics, Medical/*education
MH  - Hospitals, Religious
MH  - Humans
MH  - *Internship and Residency
MH  - *Multi-Institutional Systems
MH  - Organizational Case Studies
MH  - Philadelphia
EDAT- 2012/05/26 06:00
MHDA- 2012/07/04 06:00
CRDT- 2012/05/26 06:00
PHST- 2012/05/26 06:00 [entrez]
PHST- 2012/05/26 06:00 [pubmed]
PHST- 2012/07/04 06:00 [medline]
PST - ppublish
SO  - Health Prog. 2012 May-Jun;93(3):30-1.


PMID- 22624229
OWN - NLM
STAT- MEDLINE
DCOM- 20120703
LR  - 20120525
IS  - 0882-1577 (Print)
IS  - 0882-1577 (Linking)
VI  - 93
IP  - 3
DP  - 2012 May-Jun
TI  - The Catholic Teaching Hospital: ethics education enhances skills of doctors in
      training.
PG  - 28-37
FAU - Tuohey, John
AU  - Tuohey J
AD  - Providence Center for Health Care Ethics, Providence St. Vincent Medical Center, 
      Portland, Ore., USA.
FAU - Kockler, Nicholas J
AU  - Kockler NJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Health Prog
JT  - Health progress (Saint Louis, Mo.)
JID - 8500263
MH  - Catholicism
MH  - Ethics, Medical/*education
MH  - Hospitals, Religious
MH  - *Hospitals, Teaching
MH  - Humans
MH  - *Physicians
MH  - *Professional Competence
EDAT- 2012/05/26 06:00
MHDA- 2012/07/04 06:00
CRDT- 2012/05/26 06:00
PHST- 2012/05/26 06:00 [entrez]
PHST- 2012/05/26 06:00 [pubmed]
PHST- 2012/07/04 06:00 [medline]
PST - ppublish
SO  - Health Prog. 2012 May-Jun;93(3):28-37.


PMID- 22624168
STAT- Publisher
DA  - 20120525
PB  - Agency for Healthcare Research and Quality (US)
CTI - AHRQ Methods Future Research Needs Series
DP  - 2012 Mar
BTI - Framework for Considering Study Designs for Future Research Needs
AB  - The Agency for Healthcare Research and Quality (AHRQ) commissioned a series of
      methods papers to describe and provisionally recommend methods for the Future
      Research Needs (FRN) projects and reports. Our paper proposes a method for
      composing the study design considerations portion of FRN reports; this portion
      discusses proposed research designs for addressing the high-priority research
      needs as determined by stakeholder opinion. Each proposed research design is
      accompanied by a discussion of advantages and disadvantages for using the
      approach. Here we present a framework based on a standard taxonomy for study
      designs and criteria for evaluating the appropriateness of a study design to
      address a particular research need. Criteria for evaluating each design include
      the advantages of the study design for producing a valid result; the resources
      needed and duration of the proposed study; the availability of data or ability to
      recruit; and ethical, legal, or social issues. The study design discussions are
      intended to be considerations and not prescriptive to researchers or funders.
      This framework is intended to help FRN project teams consistently apply criteria 
      to determine which study design may be most appropriate for each research
      question, and to provide suggestions for the rationale and presentation of their 
      design choices.
FAU - Carey, Timothy S
AU  - Carey TS
FAU - Sanders, Gillian D
AU  - Sanders GD
FAU - Viswanathan, Meera
AU  - Viswanathan M
FAU - Trikalinos, Thomas A
AU  - Trikalinos TA
FAU - Kato, Elisabeth
AU  - Kato E
FAU - Chang, Stephanie
AU  - Chang S
LA  - eng
PT  - Review
PT  - Book
PL  - Rockville (MD)
EDAT- 2012/05/25 06:00
MHDA- 2012/05/25 06:00
CDAT- 2012/05/25 06:00
AID - NBK95273 [bookaccession]


PMID- 22623930
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20220317
IS  - 2008-0255 (Electronic)
IS  - 1735-3327 (Linking)
VI  - 9
IP  - 2
DP  - 2012 Mar
TI  - Prevalence of eruption status of third molars in Libyan students.
PG  - 152-7
AB  - BACKGROUND: The aim of the present study is to determine the number of third
      molars per person, angulation, level, amount of space for eruption of third molar
      between ramus of mandible and second molar and the eruption status of third molar
      in a group of Libyan students, with different impaction patterns and agenesis of 
      third molars. MATERIALS AND METHODS: In this descriptive retrospective study, a
      total of 200 students (100 male and 100 female students of bachelor of dental
      surgery, Faculty of Dentistry, Garyounis University, Benghazi, Libya) were
      enrolled. Students who had complete complement of teeth within the age group
      17-26 years were selected for this study, while those cases who had history of
      extraction of any of the teeth or who refused to give consent were excluded.
      Before starting the study, ethical concern from the ethical committee, IRB and
      informed consent from each student who underwent radiography were obtained.
      RESULTS: The results showed that 5% of third molars were congenitally missing.
      Approximately 93.5% of the subjects had all four third molars, 1% had two third
      molars and 0.5% had one third molars with 2.5% having agenesis of all third
      molars. Third molar agenesis showed predilection for maxilla with higher
      proportion in females (3%) than males (2.1%). Angular position was maximum with
      vertical position (5.83%), with least being horizontal impactions. Level of
      occlusal plane of third molar similar to that of adjacent tooth was seen in
      44.74%, below the occlusal plane in 24.76%, totally impacted noted in 30%.
      CONCLUSION: The present study showed that 33% of the teeth were fully erupted and
      66% were in various stages of eruption and 5% were congenitally missing in these 
      students.
FAU - Byahatti, Sujata
AU  - Byahatti S
AD  - Department of Oral Medicine, Diagnosis and Radiology at Faculty of Dentistry,
      Garyounis University, Benghazi, Libya.
FAU - Ingafou, Mohammed S H
AU  - Ingafou MS
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Dent Res J (Isfahan)
JT  - Dental research journal
JID - 101471186
PMC - PMC3353690
OTO - NOTNLM
OT  - Dental
OT  - epidemiology
OT  - impacted molar
OT  - prevalence
EDAT- 2012/05/25 06:00
MHDA- 2012/05/25 06:01
CRDT- 2012/05/25 06:00
PHST- 2012/05/25 06:00 [entrez]
PHST- 2012/05/25 06:00 [pubmed]
PHST- 2012/05/25 06:01 [medline]
AID - 10.4103/1735-3327.95228 [doi]
PST - ppublish
SO  - Dent Res J (Isfahan). 2012 Mar;9(2):152-7. doi: 10.4103/1735-3327.95228.


PMID- 22623699
OWN - NLM
STAT- MEDLINE
DCOM- 20120813
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 263
IP  - 3
DP  - 2012 Jun
TI  - Time-resolved CT angiography for the detection and classification of endoleaks.
PG  - 917-26
LID - 10.1148/radiol.12111217 [doi]
AB  - PURPOSE: To assess the feasibility and diagnostic performance of time-resolved
      computed tomographic (CT) angiography in the detection and classification of
      endoleaks after endovascular aortic aneurysm repair (EVAR) in high-risk patients.
      MATERIALS AND METHODS: The study was approved by our ethics committee. Written
      informed consent was obtained from all participating patients. Fifty-four
      patients (42 male and 12 female patients; mean age, 70.9 years +/- 9.3 [standard 
      deviation]) with either thoracic (n = 8) or abdominal (n = 46) aortic aneurysms
      treated with a stent-graft were prospectively included. The patients were
      examined with a time-resolved CT angiographic protocol consisting of 12 low-dose 
      phases (80 kVp; 120 mAs [effective]; scan range, 27 cm), with 60 mL of iomeprol. 
      Patients with abdominal aneurysm repair also underwent contrast material-enhanced
      (CE) ultrasonography (US). The time delay between contrast enhancement within the
      stent lumen and the endoleak was measured. Effective radiation dose was
      calculated from the scanner protocols. Measures of diagnostic performance for the
      detection of endoleaks were calculated for time-resolved CT angiography, with CE 
      US serving as the reference standard. RESULTS: All time-resolved CT angiographic 
      data sets were diagnostic. Mean effective radiation dose was 14.6 mSv. Four
      thoracic and 19 abdominal endoleaks were identified by using time-resolved CT
      angiography. Seventeen of 19 abdominal endoleaks were confirmed with CE US. This 
      rate resulted in a sensitivity of 94%, a specificity of 93%, a positive
      predictive value of 89%, and a negative predictive value of 96% for time-resolved
      CT angiography after abdominal EVAR. Type I endoleaks showed significantly
      earlier mean peak contrast enhancement (0.28 second +/- 0.83) compared with that 
      for type II endoleaks (9.17 seconds +/- 3.59, P < .0001). CONCLUSION:
      Time-resolved CT angiography with 12 low-dose phases is feasible for patients
      after thoracic and abdominal EVAR. The protocol approximates the radiation dose
      of standard triphasic protocols. Its dynamic information differentiates types of 
      endoleaks and shows high diagnostic performance.
FAU - Sommer, Wieland H
AU  - Sommer WH
AD  - Department of Clinical Radiology, University Hospitals-Grosshadern,
      Ludwig-Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany.
      wieland.sommer@med.uni-muenchen.de
FAU - Becker, Christoph R
AU  - Becker CR
FAU - Haack, Mareike
AU  - Haack M
FAU - Rubin, Geoffrey D
AU  - Rubin GD
FAU - Weidenhagen, Rolf
AU  - Weidenhagen R
FAU - Schwarz, Florian
AU  - Schwarz F
FAU - Nikolaou, Konstantin
AU  - Nikolaou K
FAU - Reiser, Maximilian F
AU  - Reiser MF
FAU - Johnson, Thorsten R
AU  - Johnson TR
FAU - Clevert, Dirk A
AU  - Clevert DA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - 0 (Phospholipids)
RN  - 0 (contrast agent BR1)
RN  - 17E17JBP8L (iomeprol)
RN  - JR13W81H44 (Iopamidol)
RN  - WS7LR3I1D6 (Sulfur Hexafluoride)
SB  - IM
MH  - Aged
MH  - Angiography/*methods
MH  - Aortic Aneurysm/*diagnostic imaging/*therapy
MH  - Contrast Media
MH  - Endoleak/classification/*diagnostic imaging
MH  - *Endovascular Procedures
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Iopamidol/analogs & derivatives
MH  - Male
MH  - Phospholipids
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Sensitivity and Specificity
MH  - Statistics, Nonparametric
MH  - Sulfur Hexafluoride
MH  - Time Factors
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2012/05/25 06:00
MHDA- 2012/08/14 06:00
CRDT- 2012/05/25 06:00
PHST- 2012/05/25 06:00 [entrez]
PHST- 2012/05/25 06:00 [pubmed]
PHST- 2012/08/14 06:00 [medline]
AID - 263/3/917 [pii]
AID - 10.1148/radiol.12111217 [doi]
PST - ppublish
SO  - Radiology. 2012 Jun;263(3):917-26. doi: 10.1148/radiol.12111217.


PMID- 22623695
OWN - NLM
STAT- MEDLINE
DCOM- 20120813
LR  - 20220331
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 263
IP  - 3
DP  - 2012 Jun
TI  - Tibial stress injury: relationship of radiographic, nuclear medicine bone
      scanning, MR imaging, and CT Severity grades to clinical severity and time to
      healing.
PG  - 811-8
LID - 10.1148/radiol.12102426 [doi]
AB  - PURPOSE: To examine the relationship between severity grade for radiography,
      triple-phase technetium 99m nuclear medicine bone scanning, magnetic resonance
      (MR) imaging, and computed tomography (CT); clinical severity; and recovery time 
      from a tibial stress injury (TSI), as well as to evaluate interassessor grading
      reliability. MATERIALS AND METHODS: This protocol was approved by the Griffith
      University Human Research Ethics Committee, the Stanford University Panel on
      Human Subjects in Medical Research, the U.S. Army Human Subjects Research Review 
      Board, and the Australian Defense Human Research Ethics Committee. Informed
      consent was obtained from all subjects. Forty subjects (17 men, 23 women; mean
      age, 26.2 years +/- 6.9 [standard deviation]) with TSI were enrolled. Subjects
      were examined acutely with standard anteroposterior and lateral radiography,
      nuclear medicine scanning, MR imaging, and CT. Each modality was graded by four
      blinded clinicians. Mixed-effects models were used to examine associations
      between image severity, clinical severity, and time to healing, with adjustments 
      for image modality and assessor. Grading reliability was evaluated with the
      Cronbach alpha coefficient. RESULTS: Image assessment reliability was high for
      all grading systems except radiography, which was moderate (alpha = 0.565-0.895).
      Clinical severity was negatively associated with MR imaging severity (P </=
      .001). There was no significant relationship between time to healing and severity
      score for any imaging modality, although a positive trend existed for MR imaging 
      (P = .07). CONCLUSION: TSI clinical severity was negatively related to MR imaging
      severity. Radiographic, bone scan, and CT severity were not related to time to
      healing, but there was a positive trend for MR imaging.
FAU - Beck, Belinda R
AU  - Beck BR
AD  - School of Physiotherapy and Exercise Science, Centre for Musculoskeletal
      Research, Griffith University, Gold Coast campus, Griffth, QLD 4222, Australia.
      b.beck@griffith.edu.au
FAU - Bergman, A Gabrielle
AU  - Bergman AG
FAU - Miner, Mark
AU  - Miner M
FAU - Arendt, Elizabeth A
AU  - Arendt EA
FAU - Klevansky, Alan B
AU  - Klevansky AB
FAU - Matheson, Gordon O
AU  - Matheson GO
FAU - Norling, Tracey L
AU  - Norling TL
FAU - Marcus, Robert
AU  - Marcus R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
CIN - Clin J Sport Med. 2013 Mar;23(2):118-9. PMID: 23478785
EIN - Radiology. 2012 Sep;264(3):920
MH  - Adult
MH  - Athletic Injuries/*diagnosis
MH  - Female
MH  - Fractures, Stress/*diagnosis
MH  - Humans
MH  - Injury Severity Score
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Pain Measurement
MH  - Positron-Emission Tomography
MH  - Tibia/*injuries
MH  - Tibial Fractures/*diagnosis
MH  - Time Factors
MH  - Tomography, X-Ray Computed
MH  - Wound Healing
EDAT- 2012/05/25 06:00
MHDA- 2012/08/14 06:00
CRDT- 2012/05/25 06:00
PHST- 2012/05/25 06:00 [entrez]
PHST- 2012/05/25 06:00 [pubmed]
PHST- 2012/08/14 06:00 [medline]
AID - 263/3/811 [pii]
AID - 10.1148/radiol.12102426 [doi]
PST - ppublish
SO  - Radiology. 2012 Jun;263(3):811-8. doi: 10.1148/radiol.12102426.


PMID- 22623689
OWN - NLM
STAT- MEDLINE
DCOM- 20120813
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 263
IP  - 3
DP  - 2012 Jun
TI  - The Lazarus syndrome: the ethics of evidence-based versus experience-based
      medicine.
PG  - 629-32
LID - 10.1148/radiol.12120147 [doi]
FAU - Brant-Zawadzki, Michael
AU  - Brant-Zawadzki M
AD  - Department of Radiology, Hoag Neurosciences Institute, 1 Hoag Dr, Newport Beach, 
      CA 92658, USA. mbrant@hoag.org
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
CIN - Radiology. 2012 Dec;265(3):976; author reply 977. PMID: 23175550
MH  - Aneurysm, Ruptured/diagnostic imaging/*therapy
MH  - Cerebral Angiography
MH  - Decision Making/*ethics
MH  - Embolization, Therapeutic/*methods
MH  - Evidence-Based Medicine/*ethics
MH  - Female
MH  - Humans
MH  - Intensive Care Units/*economics/*ethics
MH  - Intracranial Aneurysm/diagnostic imaging/*therapy
MH  - Middle Aged
MH  - Subarachnoid Hemorrhage/diagnostic imaging/*therapy
MH  - Tomography, X-Ray Computed
EDAT- 2012/05/25 06:00
MHDA- 2012/08/14 06:00
CRDT- 2012/05/25 06:00
PHST- 2012/05/25 06:00 [entrez]
PHST- 2012/05/25 06:00 [pubmed]
PHST- 2012/08/14 06:00 [medline]
AID - 263/3/629 [pii]
AID - 10.1148/radiol.12120147 [doi]
PST - ppublish
SO  - Radiology. 2012 Jun;263(3):629-32. doi: 10.1148/radiol.12120147.


PMID- 22622949
OWN - NLM
STAT- MEDLINE
DCOM- 20121108
LR  - 20191210
IS  - 1525-1438 (Electronic)
IS  - 1048-891X (Linking)
VI  - 22
IP  - 6
DP  - 2012 Jul
TI  - 18-fluoro-deoxy-glucose positron emission tomography with computed
      tomography-based gross tumor volume estimation and validation with magnetic
      resonance imaging for locally advanced cervical cancers.
PG  - 1031-6
LID - 10.1097/IGC.0b013e318251046b [doi]
AB  - PURPOSE: Anatomy and morphology-based imaging is routinely used for radiotherapy 
      purpose to deliver precision treatment. There is an interest in using information
      from functional imaging for conformal radiation therapy planning. These
      functional imaging techniques need to be validated rigorously before their
      routine use. We attempted to evaluate and validate the use of
      18-fluoro-deoxy-glucose positron emission tomography with computed tomography
      ((1)(8)FDG PET-CT) on primary tumor of the cervical carcinoma, with an aim of
      arriving at a cutoff maximum standardized uptake value (SUVmax) at which the
      tumor volume correlates best with magnetic resonance imaging (MRI). This
      observational study was a part of an ethics committee-approved study evaluating
      pretreatment MRI and FDG PET-CT. MATERIALS AND METHODS: Patients' biopsy-proven
      cervical carcinomas (stages IIB and IIIB) were included in this study and
      underwent pretreatment MRI and FDG PET-CT as per institutional protocol. Volumes 
      of the disease at the cervix on the MR image were calculated. Volumes at the FDG 
      PET-CT scan at different percentages of SUVmax were auto contoured. Volume at MRI
      was correlated with each different percentage cutoff of the SUVmax. RESULTS: Data
      of 74 patients were available for the study. The mean (SD) SUVmax of the primary 
      tumor was 15.7 (7.0). The mean MRI volume correlates significantly (P < 0.001)
      with 30% and 35% of SUVmax values with good correlation according to the Pearson 
      bivariate correlation (r = 0.79 each). The mean difference between MRI and PET
      volumes was least with 30% SUVmax. CONCLUSIONS: (1)(8)FDG PET-CT SUV-based
      primary tumor volume estimation at 30% to 35% of SUVmax values correlates
      significantly with the criterion standard MR volumes for primary cervical tumor
      with squamous histology in our population.
FAU - Upasani, Maheshkumar N
AU  - Upasani MN
AD  - Department of Radiation Oncology & Medical Physics, Tata Memorial Hospital,
      Parel, Mumbai, India.
FAU - Mahantshetty, Umesh M
AU  - Mahantshetty UM
FAU - Rangarajan, Venkatesh
AU  - Rangarajan V
FAU - Purandare, Nilendu
AU  - Purandare N
FAU - Merchant, Nikhil
AU  - Merchant N
FAU - Thakur, Meenakshi
AU  - Thakur M
FAU - Engineer, Reena
AU  - Engineer R
FAU - Chopra, Supriya
AU  - Chopra S
FAU - Shrivastava, Shyam Kishore
AU  - Shrivastava SK
LA  - eng
PT  - Journal Article
PT  - Validation Study
PL  - England
TA  - Int J Gynecol Cancer
JT  - International journal of gynecological cancer : official journal of the
      International Gynecological Cancer Society
JID - 9111626
RN  - 0 (Radiopharmaceuticals)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/*diagnostic imaging
MH  - Female
MH  - *Fluorodeoxyglucose F18
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Middle Aged
MH  - Positron-Emission Tomography
MH  - *Radiopharmaceuticals
MH  - Tomography, X-Ray Computed
MH  - Uterine Cervical Neoplasms/*diagnostic imaging
EDAT- 2012/05/25 06:00
MHDA- 2012/11/09 06:00
CRDT- 2012/05/25 06:00
PHST- 2012/05/25 06:00 [entrez]
PHST- 2012/05/25 06:00 [pubmed]
PHST- 2012/11/09 06:00 [medline]
AID - 10.1097/IGC.0b013e318251046b [doi]
PST - ppublish
SO  - Int J Gynecol Cancer. 2012 Jul;22(6):1031-6. doi: 10.1097/IGC.0b013e318251046b.


PMID- 22622788
OWN - NLM
STAT- MEDLINE
DCOM- 20121015
LR  - 20211021
IS  - 1432-1203 (Electronic)
IS  - 0340-6717 (Linking)
VI  - 131
IP  - 9
DP  - 2012 Sep
TI  - Recommendations for ethical approaches to genotype-driven research recruitment.
PG  - 1423-31
LID - 10.1007/s00439-012-1177-z [doi]
AB  - Recruiting research participants based on genetic information generated about
      them in a prior study is a potentially powerful way to study the functional
      significance of human genetic variation. However, it also presents significant
      ethical challenges that, to date, have received only minimal consideration. We
      convened a multi-disciplinary workshop to discuss key issues relevant to the
      conduct and oversight of genotype-driven recruitment and to translate those
      considerations into practical policy recommendations. Workshop participants were 
      invited from around the US, and included genomic researchers and study
      coordinators, research participants, clinicians, bioethics scholars, experts in
      human research protections, and government representatives. Discussion was
      directed by experienced facilitators and informed by empirical data collected in 
      a national survey of IRB chairs and in-depth interviews with research
      participants in studies where genotype-driven recontact occurred. A high degree
      of consensus was attained on the resulting seven recommendations, which cover
      informed consent disclosures and choices, the process for how and by whom
      participants are recontacted, the disclosure of individual genetic research
      results, and the importance of tailoring approaches based on specific contextual 
      factors. These recommendations are intended to represent a balanced
      approach-protecting research participants, yet avoiding overly restrictive
      policies that hinder advancement on important scientific questions.
FAU - Beskow, Laura M
AU  - Beskow LM
AD  - Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708,
      USA. laura.beskow@duke.edu
FAU - Fullerton, Stephanie M
AU  - Fullerton SM
FAU - Namey, Emily E
AU  - Namey EE
FAU - Nelson, Daniel K
AU  - Nelson DK
FAU - Davis, Arlene M
AU  - Davis AM
FAU - Wilfond, Benjamin S
AU  - Wilfond BS
LA  - eng
GR  - RC1 HG005787/HG/NHGRI NIH HHS/United States
GR  - UL1RR025014/RR/NCRR NIH HHS/United States
GR  - RC1HG005787/HG/NHGRI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20120524
PL  - Germany
TA  - Hum Genet
JT  - Human genetics
JID - 7613873
SB  - IM
CIN - Am J Bioeth. 2017 Apr;17(4):62-63. PMID: 28328354
CIN - Am J Bioeth. 2017 Apr;17(4):64-65. PMID: 28328375
MH  - *Ethics
MH  - *Genotype
MH  - Humans
MH  - Personnel Selection/*ethics
MH  - United States
PMC - PMC3686635
MID - NIHMS477200
EDAT- 2012/05/25 06:00
MHDA- 2012/10/16 06:00
CRDT- 2012/05/25 06:00
PHST- 2012/02/27 00:00 [received]
PHST- 2012/05/04 00:00 [accepted]
PHST- 2012/05/25 06:00 [entrez]
PHST- 2012/05/25 06:00 [pubmed]
PHST- 2012/10/16 06:00 [medline]
AID - 10.1007/s00439-012-1177-z [doi]
PST - ppublish
SO  - Hum Genet. 2012 Sep;131(9):1423-31. doi: 10.1007/s00439-012-1177-z. Epub 2012 May
      24.


PMID- 22622651
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20130412
IS  - 1529-7535 (Print)
IS  - 1529-7535 (Linking)
VI  - 13
IP  - 5
DP  - 2012 Sep
TI  - Placement of peripherally inserted central catheters in children guided by
      ultrasound: a prospective randomized, and controlled trial.
PG  - e282-7
LID - 10.1097/PCC.0b013e318245597c [doi]
AB  - OBJECTIVE: To compare the use of vascular Doppler ultrasound with vein
      visualization and palpation for positioning peripherally inserted central
      catheters in children and to determine the influence of these methods on the
      success of the first puncture attempt, catheter positioning, and time required
      for the accomplishment. DESIGN: A prospective randomized, controlled trial was
      conducted in a university hospital after ethical approval and was carried out
      among children (from birth to 18 yrs). SETTING: Sao Paulo Hospital, Sao Paulo,
      Brazil. PATIENTS: The sample comprises 42 peripherally inserted central catheters
      insertions allocated randomly into two groups: 1) an ultrasound group with 21
      peripherally inserted central catheters guided by ultrasound; and 2) a control
      group with 21 catheters, in which the peripherally inserted central catheters
      were inserted using vein visualization and palpation. INTERVENTIONS: The
      procedure was performed by two trained nurses using a standard protocol for
      peripherally inserted central catheter insertion and ultrasound use. Ultrasound
      group equipment was ILook25 (Sonosite, Bothell, WA) with a 25-mm, 10- to 15-MHz
      linear array transducer that reaches a 4-cm depth. MEASUREMENTS AND MAIN RESULTS:
      Success in the first puncture attempt was higher (p = .003) in the ultrasound
      group (90.5%) than in the control group (47.6%). The catheter positioning success
      rate was 85.7% in the ultrasound group and 52.4% in the control group (p = .019).
      The median time spent on the procedure for the ultrasound group was 20 mins,
      whereas it was 50 mins for the control group (p = .001). CONCLUSION: The use of
      ultrasound increased the successful positioning of peripherally inserted central 
      catheters in comparison with the venous anatomic landmark visualization and
      palpation technique and further optimized the time spent on the procedure.
FAU - de Carvalho Onofre, Priscilla Sete
AU  - de Carvalho Onofre PS
AD  - Universidade Federal de Sao Paulo (PSCO), Unifesp, Sao Paulo, Brazil.
FAU - da Luz Goncalves Pedreira, Mavilde
AU  - da Luz Goncalves Pedreira M
FAU - Peterlini, Maria Angelica Sorgini
AU  - Peterlini MA
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pediatr Crit Care Med
JT  - Pediatric critical care medicine : a journal of the Society of Critical Care
      Medicine and the World Federation of Pediatric Intensive and Critical Care
      Societies
JID - 100954653
SB  - IM
CIN - Pediatr Crit Care Med. 2012 Sep;13(5):607-8. PMID: 22955466
CIN - Pediatr Crit Care Med. 2013 Mar;14(3):336-7. PMID: 23462361
CIN - Pediatr Crit Care Med. 2013 Mar;14(3):337-8. PMID: 23462362
MH  - Adolescent
MH  - Catheterization, Peripheral/*methods
MH  - Chi-Square Distribution
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Operative Time
MH  - *Palpation
MH  - Statistics, Nonparametric
MH  - *Ultrasonography, Doppler
MH  - *Ultrasonography, Interventional
EDAT- 2012/05/25 06:00
MHDA- 2013/03/13 06:00
CRDT- 2012/05/25 06:00
PHST- 2012/05/25 06:00 [entrez]
PHST- 2012/05/25 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
AID - 10.1097/PCC.0b013e318245597c [doi]
PST - ppublish
SO  - Pediatr Crit Care Med. 2012 Sep;13(5):e282-7. doi: 10.1097/PCC.0b013e318245597c.


PMID- 22622205
OWN - NLM
STAT- MEDLINE
DCOM- 20120904
LR  - 20211021
IS  - 1938-808X (Electronic)
IS  - 1040-2446 (Linking)
VI  - 87
IP  - 7
DP  - 2012 Jul
TI  - How closely do institutional review boards follow the common rule?
PG  - 969-74
LID - 10.1097/ACM.0b013e3182575e2e [doi]
AB  - PURPOSE: To determine how closely institutional review board (IRB) discussions
      reflect the ethical criteria specified in the Common Rule federal regulations.
      METHOD: Between November 2006 and July 2009, the authors observed,
      audio-recorded, transcribed, and coded protocol reviews from 20 IRB meetings at
      10 leading academic medical centers. They also reviewed each of the applications 
      discussed to identify the Common Rule criteria-(1) risk minimization, (2)
      risk/benefit comparison, (3) equitable subject selection, (4) informed consent,
      (5) data monitoring to ensure safety, (6) privacy protection and confidentiality,
      and (7) protection of vulnerable subjects-that were both relevant to the study
      and not adequately addressed in the application. They then determined if the IRB 
      addressed each of the relevant and not-discussed Common Rule criteria in their
      discussions. RESULTS: IRBs made no mention of many of the Common Rule criteria
      that required their discussion-In 17/82 (21%) reviews, they failed to address
      risk minimization; in 52/91 (57%), risk/benefit comparison; in 31/52 (60%),
      equitable subject selection; in 32/59 (54%), data monitoring; in 13/52 (25%),
      privacy and confidentiality; and in 7/55 (13%), protection of vulnerable
      populations. However, they discussed informed consent in 102/104 (98%) reviews
      and raised questions about, or requested changes about, informed consent for
      92/104 (88%) protocols. CONCLUSIONS: These findings suggest that essential
      elements of human subjects protection are not implemented uniformly across IRBs. 
      Although not directly addressing this issue, the current proposed changes to the 
      Common Rule offer an opportunity to improve, in general, the effectiveness of
      IRBs to protect human subjects.
FAU - Lidz, Charles W
AU  - Lidz CW
AD  - Department of Psychiatry, University of Massachusetts Medical School, Worcester, 
      MA 01605-2805, USA. Charles.lidz@umassmed.edu
FAU - Appelbaum, Paul S
AU  - Appelbaum PS
FAU - Arnold, Robert
AU  - Arnold R
FAU - Candilis, Philip
AU  - Candilis P
FAU - Gardner, William
AU  - Gardner W
FAU - Myers, Suzanne
AU  - Myers S
FAU - Simon, Lorna
AU  - Simon L
LA  - eng
GR  - R01 CA107295/CA/NCI NIH HHS/United States
GR  - UL1 RR024153/RR/NCRR NIH HHS/United States
GR  - UL1 TR000005/TR/NCATS NIH HHS/United States
GR  - 5 R01 CA107295/CA/NCI NIH HHS/United States
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Acad Med
JT  - Academic medicine : journal of the Association of American Medical Colleges
JID - 8904605
SB  - IM
MH  - Ethics Committees, Research/legislation & jurisprudence/*standards/statistics &
      numerical data
MH  - Federal Government
MH  - *Government Regulation
MH  - Guideline Adherence/*statistics & numerical data
MH  - Human Experimentation/ethics/*legislation & jurisprudence/standards
MH  - Humans
MH  - Tape Recording
MH  - United States
PMC - PMC3386463
MID - NIHMS373568
EDAT- 2012/05/25 06:00
MHDA- 2012/09/05 06:00
CRDT- 2012/05/25 06:00
PHST- 2012/05/25 06:00 [entrez]
PHST- 2012/05/25 06:00 [pubmed]
PHST- 2012/09/05 06:00 [medline]
AID - 10.1097/ACM.0b013e3182575e2e [doi]
PST - ppublish
SO  - Acad Med. 2012 Jul;87(7):969-74. doi: 10.1097/ACM.0b013e3182575e2e.


PMID- 22621824
OWN - NLM
STAT- MEDLINE
DCOM- 20121109
LR  - 20161109
IS  - 1578-178X (Electronic)
IS  - 0033-8338 (Linking)
VI  - 54
IP  - 3
DP  - 2012 May-Jun
TI  - [Ethical aspects of research in radiology].
PG  - 202-7
LID - 10.1016/j.rx.2012.01.009 [doi]
AB  - Clinical research on human beings is essential for progress in medicine; however,
      it is also essential to safeguard research subjects' autonomy, dignity, and
      rights. Diverse documents have been developed in consensus to address these
      issues: some of the most relevant are the Nuremberg Code, the Helsinki
      Declaration, and the Oviedo Convention. In addition to being familiar with these 
      fundamental documents, all radiologists who conduct research should know about
      Ethics Committees and consult them about the methodology of their studies, which 
      must fulfill the conditions stipulated in the above-mentioned guidelines as well 
      as in the legislation in force.
CI  - Copyright (c) 2011 SERAM. Published by Elsevier Espana. All rights reserved.
FAU - Pina, L
AU  - Pina L
AD  - Departamento de Radiologia, Clinica Universidad de Navarra, Pamplona, Espana.
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Aspectos eticos en la investigacion en Radiologia.
DEP - 20120522
PL  - Spain
TA  - Radiologia
JT  - Radiologia
JID - 0120775
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Codes of Ethics
MH  - Ethics Committees
MH  - Humans
MH  - Informed Consent
MH  - Radiology/*ethics
EDAT- 2012/05/25 06:00
MHDA- 2012/11/10 06:00
CRDT- 2012/05/25 06:00
PHST- 2011/12/30 00:00 [received]
PHST- 2012/01/08 00:00 [revised]
PHST- 2012/01/14 00:00 [accepted]
PHST- 2012/05/25 06:00 [entrez]
PHST- 2012/05/25 06:00 [pubmed]
PHST- 2012/11/10 06:00 [medline]
AID - S0033-8338(12)00060-4 [pii]
AID - 10.1016/j.rx.2012.01.009 [doi]
PST - ppublish
SO  - Radiologia. 2012 May-Jun;54(3):202-7. doi: 10.1016/j.rx.2012.01.009. Epub 2012
      May 22.


PMID- 22621153
OWN - NLM
STAT- MEDLINE
DCOM- 20120727
LR  - 20190902
IS  - 1326-5377 (Electronic)
IS  - 0025-729X (Linking)
VI  - 196
IP  - 9
DP  - 2012 May 21
TI  - Out of sight, out of mind: making involuntary community treatment visible in the 
      mental health system.
PG  - 591-3
AB  - Most specialised mental health services in Australia are delivered in community
      settings and one in six services comprise involuntary treatment. Despite a
      growing demand for community treatment orders (CTOs) worldwide - and
      comparatively high rates of use in Australia - the clinical, legal and ethical
      aspects of CTOs remain contentious. This article examines federal, state and
      territory mental health policy documents and discovers little reference to CTOs. 
      The "invisibility" of CTOs in mental health policy raises questions about the
      transparency and accountability of the mental health system, and about whether
      this policy silence ultimately entrenches the marginalisation of, and
      discrimination against, people living with mental illness.
FAU - Light, Edwina M
AU  - Light EM
AD  - Centre for Values, Ethics and the Law in Medicine, University of Sydney, Sydney, 
      NSW. edwina.light@sydney.edu.au
FAU - Kerridge, Ian H
AU  - Kerridge IH
FAU - Ryan, Christopher J
AU  - Ryan CJ
FAU - Robertson, Michael D
AU  - Robertson MD
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Med J Aust
JT  - The Medical journal of Australia
JID - 0400714
SB  - IM
MH  - Australia
MH  - Community Mental Health Services/*ethics/legislation & jurisprudence
MH  - Health Care Reform
MH  - *Health Policy
MH  - Humans
MH  - Informed Consent/*ethics/legislation & jurisprudence
MH  - Mental Disorders/therapy
MH  - Mentally Ill Persons/legislation & jurisprudence
MH  - Patient Rights
MH  - Social Responsibility
EDAT- 2012/05/25 06:00
MHDA- 2012/07/28 06:00
CRDT- 2012/05/25 06:00
PHST- 2012/05/25 06:00 [entrez]
PHST- 2012/05/25 06:00 [pubmed]
PHST- 2012/07/28 06:00 [medline]
AID - 10.5694/mja11.11216 [pii]
AID - 10.5694/mja11.11216 [doi]
PST - ppublish
SO  - Med J Aust. 2012 May 21;196(9):591-3. doi: 10.5694/mja11.11216.


PMID- 22619879
OWN - NLM
STAT- MEDLINE
DCOM- 20120703
LR  - 20170214
IS  - 0840-4704 (Print)
IS  - 0840-4704 (Linking)
VI  - 25
IP  - 1
DP  - 2012 Spring
TI  - Organizational ethics: no longer the elephant in the room.
PG  - 37-43
FAU - Gibson, Jennifer L
AU  - Gibson JL
AD  - jennifer.gibson@utoronto.ca
LA  - eng
LA  - fre
PT  - Journal Article
PL  - United States
TA  - Healthc Manage Forum
JT  - Healthcare management forum
JID - 8805307
MH  - Canada
MH  - *Ethics, Institutional
MH  - *Leadership
EDAT- 2012/05/25 06:00
MHDA- 2012/07/04 06:00
CRDT- 2012/05/25 06:00
PHST- 2012/05/25 06:00 [entrez]
PHST- 2012/05/25 06:00 [pubmed]
PHST- 2012/07/04 06:00 [medline]
AID - 10.1016/j.hcmf.2012.01.003 [doi]
PST - ppublish
SO  - Healthc Manage Forum. 2012 Spring;25(1):37-43. doi: 10.1016/j.hcmf.2012.01.003.


PMID- 22619270
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 3
DP  - 2012
TI  - The foot in multistage ultra-marathon runners: experience in a cohort study of 22
      participants of the Trans Europe Footrace Project with mobile MRI.
LID - 10.1136/bmjopen-2012-001118 [doi]
LID - e001118 [pii]
AB  - OBJECTIVES: 67 runners participated in the Trans Europe FootRace 2009 (TEFR09), a
      4487 km (2789 mi) multistage ultra-marathon covering the south of Europe (Bari,
      Italy) to the North Cape. Reports on ultra-marathons are lacking, but the
      literature reports overuse injuries in athletes, especially to the Achilles
      tendon (AT), ankle or hind foot. Bone oedema may be related to exposure and is
      present in fatigue fractures. Therefore, the aim of this study was to determine
      prospectively if sustained maximal load during an ultra-marathon leads to damage 
      to the foot. DESIGN AND PARTICIPANTS: In a cohort study, repeated scanning of the
      22 athletes participating in the study was performed before and during
      (approximately every 1000 km) the race. Using the obtained fat saturated
      inversion recovery sequence, two experienced readers blinded to the clinical data
      rated the images regarding foot lesions. Statistical analysis included regression
      analysis and computation of the inter-rater reliability. SETTING: The TEFR09
      course. MRI scanning was performed according to prearranged schedules for every
      participant, using a mobile 1.5 Tesla MRI unit on a trailer following the race.
      PRIMARY OUTCOME MEASURES: MRI data such as AT diameter, bone or tendon lesions,
      subcutaneous, plantar fascia or intraosseous oedema. RESULTS: The 22 study
      participants did not differ significantly from the total of the 67 TEFR09 runners
      regarding height, weight and age. The AT diameter increased significantly from
      6.8 to 7.8 mm as did intraosseous signal, bone lesions and subcutaneous oedema.
      However, finishers differed only regarding plantar aponeurosis and subcutaneous
      oedema from participants aborting the TEFR09. Inter-rater reliability was
      0.88-0.98. CONCLUSION: Under the extreme stress of the TEFR09, an increase of the
      AT diameter as well as bone signal are thought to be adaptive since only
      subcutaneous oedema and plantar fascia oedema were related to abortion of the
      race. TRIAL REGISTRATION NUMBER: University of Ulm, Germany Ethics Committee
      Number 78/08-UBB/se.
FAU - Freund, Wolfgang
AU  - Freund W
AD  - Department of Diagnostic and Interventional Radiology, University Hospitals, Ulm,
      Germany.
FAU - Weber, Frank
AU  - Weber F
FAU - Billich, Christian
AU  - Billich C
FAU - Schuetz, Uwe H
AU  - Schuetz UH
LA  - eng
PT  - Journal Article
DEP - 20120522
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3364457
EDAT- 2012/05/24 06:00
MHDA- 2012/05/24 06:01
CRDT- 2012/05/24 06:00
PHST- 2012/05/24 06:00 [entrez]
PHST- 2012/05/24 06:00 [pubmed]
PHST- 2012/05/24 06:01 [medline]
AID - bmjopen-2012-001118 [pii]
AID - 10.1136/bmjopen-2012-001118 [doi]
PST - epublish
SO  - BMJ Open. 2012 May 22;2(3). pii: bmjopen-2012-001118. doi:
      10.1136/bmjopen-2012-001118. Print 2012.


PMID- 22619238
OWN - NLM
STAT- MEDLINE
DCOM- 20130319
LR  - 20191210
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 19
IP  - 6
DP  - 2012 Nov
TI  - Nurses' ethical conflict with hospitals: a longitudinal study of outcomes.
PG  - 727-37
LID - 10.1177/0969733011421626 [doi]
AB  - This study examined the association of nurses' ethical conflict with hospitals
      with organizational commitment, stress, turnover intention, absence and turnover.
      Participants were 410 nurses working at four different Canadian hospitals. A
      longitudinal design was used where nurses completed a questionnaire to capture
      ethical conflict, stress and organizational commitment, and one year later,
      measures of turnover intention, absence and actual turnover were obtained for the
      same sample. We found three aspects of nurses' ethical conflict with hospitals:
      patient care values, value of nurses, and staffing policy values. Our findings
      showed that all three aspects of nurses' ethical conflict are associated with
      stress and patient care values is associated with actual turnover. We also found 
      that staffing policy values is predictive of turnover intention, and that patient
      care values is predictive of absenteeism. Thus, our findings show the
      multidimensionality of nurses' ethical conflict with hospitals. Further
      implications of our findings for practice and theory are discussed.
FAU - Gaudine, Alice
AU  - Gaudine A
AD  - School of Nursing, Memorial University of Newfoundland, Canada. agaudine@mun.ca
FAU - Thorne, Linda
AU  - Thorne L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120522
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Absenteeism
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Canada
MH  - *Conflict, Psychological
MH  - *Ethics, Institutional
MH  - *Ethics, Nursing
MH  - Follow-Up Studies
MH  - *Hospitals
MH  - Humans
MH  - Intention
MH  - Middle Aged
MH  - Nursing Methodology Research
MH  - Nursing Staff, Hospital/*psychology
MH  - Personnel Loyalty
MH  - Personnel Turnover/statistics & numerical data
MH  - Stress, Psychological
MH  - Surveys and Questionnaires
EDAT- 2012/05/24 06:00
MHDA- 2013/03/21 06:00
CRDT- 2012/05/24 06:00
PHST- 2012/05/24 06:00 [entrez]
PHST- 2012/05/24 06:00 [pubmed]
PHST- 2013/03/21 06:00 [medline]
AID - 0969733011421626 [pii]
AID - 10.1177/0969733011421626 [doi]
PST - ppublish
SO  - Nurs Ethics. 2012 Nov;19(6):727-37. doi: 10.1177/0969733011421626. Epub 2012 May 
      22.


PMID- 22619237
OWN - NLM
STAT- MEDLINE
DCOM- 20130319
LR  - 20191210
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 19
IP  - 6
DP  - 2012 Nov
TI  - Moral deliberation and nursing ethics cases: elements of a methodological
      proposal.
PG  - 764-76
LID - 10.1177/0969733011420096 [doi]
AB  - A qualitative study with an exploratory, descriptive and documentary design that 
      was conducted with the objective of identifying the elements to constitute a
      method for the analysis of accusations of and proceedings for professional ethics
      infringements. The method is based on underlying elements identified inductively 
      during analysis of professional ethics hearings judged by and filed in the
      archives of the Regional Nursing Board of Santa Catarina, Brazil, between 1999
      and 2007. The strategies developed were based on the results of an analysis of
      the findings of fact (occurrences/infractions, causes and outcomes) contained in 
      the records of 128 professional ethics hearings and on the structural elements
      (statements, rules and practices) identified in five example professional ethics 
      cases. The strategies suggested for evaluating accusations of ethics
      infringements and the procedures involved in deliberating on ethics hearings
      constitute a generic proposal that will require adaptation to the context of
      specific professional ethics accusations.
FAU - Schneider, Dulcineia Ghizoni
AU  - Schneider DG
AD  - Universidade do Sul de Santa Catarina, Brazil.
FAU - Ramos, Flavia Regina Souza
AU  - Ramos FR
LA  - eng
PT  - Journal Article
DEP - 20120522
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Brazil
MH  - *Conflict, Psychological
MH  - *Ethics Consultation
MH  - *Ethics, Nursing
MH  - Humans
MH  - *Morals
MH  - Nursing Methodology Research
MH  - Nursing Theory
MH  - Qualitative Research
EDAT- 2012/05/24 06:00
MHDA- 2013/03/21 06:00
CRDT- 2012/05/24 06:00
PHST- 2012/05/24 06:00 [entrez]
PHST- 2012/05/24 06:00 [pubmed]
PHST- 2013/03/21 06:00 [medline]
AID - 0969733011420096 [pii]
AID - 10.1177/0969733011420096 [doi]
PST - ppublish
SO  - Nurs Ethics. 2012 Nov;19(6):764-76. doi: 10.1177/0969733011420096. Epub 2012 May 
      22.


PMID- 22619236
OWN - NLM
STAT- MEDLINE
DCOM- 20120927
LR  - 20220409
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 19
IP  - 4
DP  - 2012 Jul
TI  - Nurses' perceptions of and responses to morally distressing situations.
PG  - 488-500
LID - 10.1177/0969733011436025 [doi]
AB  - Research on moral distress has paid limited attention to nurses' responses and
      actions. In a survey of nurses' perceptions of moral distress and ethical
      climate, 292 nurses answered three open-ended questions about situations that
      they considered morally distressing. Participants identified a range of
      situations as morally distressing, including witnessing unnecessary suffering,
      being forced to provide care that compromised values, and negative judgments
      about patients. They linked these situations to contextual constraints such as
      workload and described responses, including feeling incompetent and distancing
      themselves from patients. Participants described considerable effort to effect
      change, calling into question the utility of defining moral distress as an
      "inability to act due to institutional constraints" or a "failure to pursue a
      right course of action." Various understandings of moral distress operated, and
      action was integral to their responses. The findings suggest further conceptual
      work on moral distress and effort to support system-level change.
FAU - Varcoe, Colleen
AU  - Varcoe C
AD  - School of Nursing, University of British Columbia, Vancouver, BC V6 T 2B5 Canada.
      colleen.varcoe@nursing.ubc.ca
FAU - Pauly, Bernie
AU  - Pauly B
FAU - Storch, Jan
AU  - Storch J
FAU - Newton, Lorelei
AU  - Newton L
FAU - Makaroff, Kara
AU  - Makaroff K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120522
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Morals
MH  - Nursing Methodology Research
MH  - Nursing Staff, Hospital/ethics/organization & administration/*psychology
MH  - Qualitative Research
MH  - Stress, Psychological/*psychology
EDAT- 2012/05/24 06:00
MHDA- 2012/09/28 06:00
CRDT- 2012/05/24 06:00
PHST- 2012/05/24 06:00 [entrez]
PHST- 2012/05/24 06:00 [pubmed]
PHST- 2012/09/28 06:00 [medline]
AID - 0969733011436025 [pii]
AID - 10.1177/0969733011436025 [doi]
PST - ppublish
SO  - Nurs Ethics. 2012 Jul;19(4):488-500. doi: 10.1177/0969733011436025. Epub 2012 May
      22.


PMID- 22619235
OWN - NLM
STAT- MEDLINE
DCOM- 20120927
LR  - 20120703
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 19
IP  - 4
DP  - 2012 Jul
TI  - What actions promote a positive ethical climate? A critical incident study of
      nurses' perceptions.
PG  - 501-12
LID - 10.1177/0969733011436204 [doi]
AB  - Few qualitative studies explore the phenomenon of positive ethical climate and
      what actions are perceived as promoting it. Therefore, the aim of this study was 
      to explore and describe actions that acute care ward nurses perceive as promoting
      a positive ethical climate. The critical incident technique was used. Interviews 
      were conducted with 20 nurses at wards where the ethical climate was considered
      positive, according to a previous study. Meeting the needs of patients and next
      of kin in a considerate way, as well as receiving and giving support and
      information within the work group, promoted a positive ethical climate. Likewise,
      working as a team with a standard for behaviour within the work group promoted a 
      positive ethical climate. Future research should investigate other conditions
      that might also promote a positive ethical climate.
FAU - Silen, Marit
AU  - Silen M
AD  - School of Health Sciences, Jonkoping University, Sweden. marit.silen@crb.uu.se
FAU - Kjellstrom, Sofia
AU  - Kjellstrom S
FAU - Christensson, Lennart
AU  - Christensson L
FAU - Sidenvall, Birgitta
AU  - Sidenvall B
FAU - Svantesson, Mia
AU  - Svantesson M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120522
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Adult
MH  - *Attitude of Health Personnel
MH  - Female
MH  - Hospital Units/*ethics/organization & administration
MH  - Humans
MH  - Interprofessional Relations
MH  - Male
MH  - Nursing Methodology Research
MH  - Nursing Staff, Hospital/ethics/*psychology
MH  - Organizational Culture
MH  - Qualitative Research
MH  - Social Support
EDAT- 2012/05/24 06:00
MHDA- 2012/09/28 06:00
CRDT- 2012/05/24 06:00
PHST- 2012/05/24 06:00 [entrez]
PHST- 2012/05/24 06:00 [pubmed]
PHST- 2012/09/28 06:00 [medline]
AID - 0969733011436204 [pii]
AID - 10.1177/0969733011436204 [doi]
PST - ppublish
SO  - Nurs Ethics. 2012 Jul;19(4):501-12. doi: 10.1177/0969733011436204. Epub 2012 May 
      22.


PMID- 22619068
OWN - NLM
STAT- MEDLINE
DCOM- 20130314
LR  - 20120813
IS  - 1532-2149 (Electronic)
IS  - 1090-3801 (Linking)
VI  - 16
IP  - 8
DP  - 2012 Sep
TI  - An ethics code for pain.
PG  - 1081-3
LID - 10.1002/j.1532-2149.2012.00164.x [doi]
FAU - Coaccioli, S
AU  - Coaccioli S
AD  - The Paolo Procacci Foundation, Rome, Italy. http://www.fondazioneprocacci.org
FAU - Varrassi, G
AU  - Varrassi G
FAU - Marinangeli, F
AU  - Marinangeli F
FAU - Aurilio, C
AU  - Aurilio C
FAU - Finco, G
AU  - Finco G
FAU - Gatti, A
AU  - Gatti A
FAU - Geppetti, P
AU  - Geppetti P
FAU - Matucci-Cerinic, M
AU  - Matucci-Cerinic M
FAU - Polati, E
AU  - Polati E
FAU - Sabato, A F
AU  - Sabato AF
CN  - Paolo Procacci Foundation
CN  - Italian Association for the Study of Pain
LA  - eng
PT  - Guideline
PT  - Journal Article
DEP - 20120522
PL  - England
TA  - Eur J Pain
JT  - European journal of pain (London, England)
JID - 9801774
SB  - IM
MH  - *Codes of Ethics
MH  - *Ethics, Professional
MH  - Humans
MH  - Pain Management/*ethics
MH  - Pain Measurement/*ethics
EDAT- 2012/05/24 06:00
MHDA- 2013/03/15 06:00
CRDT- 2012/05/24 06:00
PHST- 2012/05/24 06:00 [entrez]
PHST- 2012/05/24 06:00 [pubmed]
PHST- 2013/03/15 06:00 [medline]
AID - 10.1002/j.1532-2149.2012.00164.x [doi]
PST - ppublish
SO  - Eur J Pain. 2012 Sep;16(8):1081-3. doi: 10.1002/j.1532-2149.2012.00164.x. Epub
      2012 May 22.


PMID- 22618481
OWN - NLM
STAT- MEDLINE
DCOM- 20120831
LR  - 20161125
IS  - 1438-9010 (Electronic)
IS  - 1438-9010 (Linking)
VI  - 184
IP  - 7
DP  - 2012 Jul
TI  - Intraoperative specimen radiography in patients with nonpalpable malignant breast
      lesions.
PG  - 635-42
LID - 10.1055/s-0032-1312730 [doi]
AB  - PURPOSE: Specimen mammography of nonpalpable wire-localized breast lesions is the
      standard in breast-conserving surgery. The aim of this study was to evaluate the 
      reliability of intraoperative 2-view specimen mammography in different cancer
      types. MATERIALS AND METHODS: After ethics approval, 3 readers retrospectively
      evaluated margins on 266 2-view specimen radiographs. They determined the closest
      margin and the orientation. The results were correlated with the histopathology
      (intra-class correlation coefficient [ICC] and contingency coefficient [CC]) and 
      compared (Wilcoxon test). RESULTS: Invasive ductal carcinoma (IDC) with ductal
      carcinoma in situ (DCIS) was present in 115 (43 %), IDC in 75 (28 %), invasive
      lobular carcinoma (ILC) in 57 (22 %) and rare cancers (CA) in 19 specimens (7 %).
      The sensitivity/specificity and positive/negative predictive value (P/NPV) of
      specimen mammography were 0.50/0.86 and 0.86/0.50 for CA, 0.42/0.68 and 0.48/0.63
      for IDC, 0.36/0.81 and 0.69/0.51 for ILC, and 0.22/0.78 and 0.68/0.32 for
      IDC+DCIS. Readers correctly identified the orientation of the closest margin in
      at least one view in an average of 149 specimens (56 %). CCs were between 0.680
      (IDC) and 0.912 (CA), suggesting a moderate correlation between radiographic and 
      histological orientation. The correlations were worse for the radiographic and
      histological distances, with ICC ranging from 0.238 (ILC) to 0.475 (CA). The
      Wilcoxon test revealed overestimation of the radiographic margins compared to the
      histological ones for DCIS. CONCLUSION: Our results suggest that specimen
      radiography has relatively good overall specificity and good PPV, while the
      sensitivity and NPV are low for DCIS. A negative result on specimen radiography
      does not rule out histologically involved margins.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Schmachtenberg, C
AU  - Schmachtenberg C
AD  - Radiology, Charite, Campus Mitte, Berlin.
FAU - Engelken, F
AU  - Engelken F
FAU - Fischer, T
AU  - Fischer T
FAU - Bick, U
AU  - Bick U
FAU - Poellinger, A
AU  - Poellinger A
FAU - Fallenberg, E M
AU  - Fallenberg EM
LA  - eng
PT  - Journal Article
DEP - 20120522
PL  - Germany
TA  - Rofo
JT  - RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin
JID - 7507497
SB  - IM
MH  - Adult
MH  - Aged
MH  - Breast Neoplasms/*diagnostic imaging/*surgery
MH  - Female
MH  - Humans
MH  - Mastectomy/*methods
MH  - Middle Aged
MH  - Observer Variation
MH  - Palpation
MH  - Radiography
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - Single-Blind Method
MH  - Surgery, Computer-Assisted/*methods
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2012/05/24 06:00
MHDA- 2012/09/01 06:00
CRDT- 2012/05/24 06:00
PHST- 2012/05/24 06:00 [entrez]
PHST- 2012/05/24 06:00 [pubmed]
PHST- 2012/09/01 06:00 [medline]
AID - 10.1055/s-0032-1312730 [doi]
PST - ppublish
SO  - Rofo. 2012 Jul;184(7):635-42. doi: 10.1055/s-0032-1312730. Epub 2012 May 22.


PMID- 22618162
OWN - NLM
STAT- MEDLINE
DCOM- 20140122
LR  - 20130807
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 3
DP  - 2013 Sep
TI  - An analysis of student privacy rights in the use of plagiarism detection systems.
PG  - 1255-66
LID - 10.1007/s11948-012-9370-y [doi]
AB  - Plagiarism detection services are a powerful tool to help encourage academic
      integrity. Adoption of these services has proven to be controversial due to
      ethical concerns about students' rights. Central to these concerns is the fact
      that most such systems make permanent archives of student work to be re-used in
      plagiarism detection. This computerization and automation of plagiarism detection
      is changing the relationships of trust and responsibility between students,
      educators, educational institutions, and private corporations. Educators must
      respect student privacy rights when implementing such systems. Student work is
      personal information, not the property of the educator or institution. The
      student has the right to be fully informed about how plagiarism detection works, 
      and the fact that their work will be permanently archived as a result.
      Furthermore, plagiarism detection should not be used if the permanent archiving
      of a student's work may expose him or her to future harm.
FAU - Brinkman, Bo
AU  - Brinkman B
AD  - Department of Computer Science and Software Engineering, Miami University,
      Oxford, OH 45056-1601, USA. Bo.Brinkman@muohio.edu
LA  - eng
PT  - Journal Article
DEP - 20120523
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Automation/ethics
MH  - *Human Rights
MH  - Humans
MH  - *Plagiarism
MH  - *Privacy
MH  - Publishing/*ethics
MH  - Social Responsibility
MH  - *Students
MH  - Trust
EDAT- 2012/05/24 06:00
MHDA- 2014/01/23 06:00
CRDT- 2012/05/24 06:00
PHST- 2009/05/06 00:00 [received]
PHST- 2012/05/05 00:00 [accepted]
PHST- 2012/05/24 06:00 [entrez]
PHST- 2012/05/24 06:00 [pubmed]
PHST- 2014/01/23 06:00 [medline]
AID - 10.1007/s11948-012-9370-y [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Sep;19(3):1255-66. doi: 10.1007/s11948-012-9370-y. Epub 2012
      May 23.


PMID- 22618161
OWN - NLM
STAT- MEDLINE
DCOM- 20131112
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 18
IP  - 3
DP  - 2012 Sep
TI  - Compassion, ethics, and neuroscience: neuroethics through Buddhist eyes.
PG  - 529-37
LID - 10.1007/s11948-012-9369-4 [doi]
AB  - As scientists advance knowledge of the brain and develop technologies to measure,
      evaluate, and manipulate brain function, numerous questions arise for religious
      adherents. If neuroscientists can conclusively establish that there is a
      functional network between neural impulses and an individual's capacity for moral
      evaluation of situations, this will naturally lead to questions about the
      relationship between such a network and constructions of moral value and ethical 
      human behavior. For example, if cognitive neuroscience can show that there is a
      neurophysiological basis for the moral appraisal of situations, it may be argued 
      that the world's religions, which have traditionally been the keepers and
      purveyors of ethical values, are rendered either spurious or irrelevant. The
      questions point up broader dilemmas in the interface between science and
      religion, and raise concerns about the ethics of neurological research and
      experimentation. Since human beings will still arbitrate what is "moral" or
      "ethical," how can religious perspectives enrich the dialogue on neuroethical
      issues and how can neuroscience enrich dialogue on religion? Buddhist views on
      the nature of consciousness and methods of practice, especially meditation
      practice, may contribute to discussions on neuroscience and theories about the
      interrelationship between consciousness and ethical awareness by exploring the
      role that karma, intentionality, and compassion play in Buddhist understandings
      of the interrelationship between consciousness and ethics.
FAU - Tsomo, Karma Lekshe
AU  - Tsomo KL
AD  - University of San Diego, Theology and Religious Studies, San Diego, CA, USA.
      ktsomo@sandiego.edu
LA  - eng
PT  - Journal Article
DEP - 20120523
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
CIN - Sci Eng Ethics. 2012 Sep;18(3):539-42. PMID: 22426623
MH  - Awareness
MH  - *Buddhism
MH  - *Comprehension
MH  - Consciousness/*ethics
MH  - *Culture
MH  - *Empathy
MH  - Humans
MH  - Intention
MH  - Meditation
MH  - Mind-Body Relations, Metaphysical
MH  - *Morals
MH  - Neurosciences/*ethics
MH  - Psychophysiology
EDAT- 2012/05/24 06:00
MHDA- 2013/11/13 06:00
CRDT- 2012/05/24 06:00
PHST- 2008/04/02 00:00 [received]
PHST- 2012/01/15 00:00 [accepted]
PHST- 2012/05/24 06:00 [entrez]
PHST- 2012/05/24 06:00 [pubmed]
PHST- 2013/11/13 06:00 [medline]
AID - 10.1007/s11948-012-9369-4 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2012 Sep;18(3):529-37. doi: 10.1007/s11948-012-9369-4. Epub 2012 
      May 23.


PMID- 22618126
OWN - NLM
STAT- MEDLINE
DCOM- 20121108
LR  - 20211021
IS  - 1534-6293 (Electronic)
IS  - 1528-4042 (Linking)
VI  - 12
IP  - 4
DP  - 2012 Aug
TI  - Critical care of the potential organ donor.
PG  - 456-65
LID - 10.1007/s11910-012-0272-9 [doi]
AB  - Organ transplantation represents one of the great success stories of 20th century
      medicine. However, its continued success is greatly limited by the shortage of
      donor organs. This has led to an increased focus within the critical care
      community on optimal identification and management of the potential organ donor. 
      The multi-organ donor can represent one of the most complex intensive care
      patients, with numerous competing physiological priorities. However, appropriate 
      management of the donor not only increases the number of organs that can be
      successfully donated but has long-term implications for the outcomes of multiple 
      recipients. This review outlines current understandings of the physiological
      derangements seen in the organ donor and evaluates the available evidence for
      management strategies designed to optimize donation potential and organ recovery.
      Finally, emerging management strategies for the potential donor are discussed
      within the current ethical and legal frameworks permitting donation after both
      brain and circulatory death.
FAU - Dare, Anna J
AU  - Dare AJ
AD  - Department of Surgery, Auckland City Hospital, University of Auckland & New
      Zealand Liver Transplant Unit, Park Road, Grafton, Auckland, New Zealand.
FAU - Bartlett, Adam S
AU  - Bartlett AS
FAU - Fraser, John F
AU  - Fraser JF
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Neurol Neurosci Rep
JT  - Current neurology and neuroscience reports
JID - 100931790
SB  - IM
MH  - Animals
MH  - Brain Death/*physiopathology
MH  - *Critical Care
MH  - Ethics, Clinical
MH  - Humans
MH  - Organ Transplantation
MH  - *Tissue Donors
MH  - Tissue and Organ Procurement
EDAT- 2012/05/24 06:00
MHDA- 2012/11/09 06:00
CRDT- 2012/05/24 06:00
PHST- 2012/05/24 06:00 [entrez]
PHST- 2012/05/24 06:00 [pubmed]
PHST- 2012/11/09 06:00 [medline]
AID - 10.1007/s11910-012-0272-9 [doi]
PST - ppublish
SO  - Curr Neurol Neurosci Rep. 2012 Aug;12(4):456-65. doi: 10.1007/s11910-012-0272-9.


PMID- 22617864
OWN - NLM
STAT- MEDLINE
DCOM- 20150522
LR  - 20211203
IS  - 1557-1246 (Electronic)
IS  - 1087-0547 (Linking)
VI  - 18
IP  - 5
DP  - 2014 Jul
TI  - In search of "anything that would help": parent perspectives on emerging
      neurotechnologies.
PG  - 395-401
LID - 10.1177/1087054712445781 [doi]
AB  - OBJECTIVE: This qualitative study explores parents' perceptions about the future 
      clinical translation of neurotechnologies--neuroimaging and genetic testing
      separately and together--for instrumentalization in the diagnosis and treatment
      of childhood ADHD. METHOD: We conducted in-person, semi-structured interviews
      with parents of minor children diagnosed with ADHD (N = 26) and analyzed 11.75 hr
      of data using constant comparative analysis. RESULTS: Receptivity to technology
      and anticipation of potential benefits overshadowed discussion of risks or
      concerns. Four key areas of potential impact on parent experience are (a) insight
      and acceptance, (b) treatment and adherence, (c) stigma and blame, and (d) the
      endeavor to access resources. CONCLUSION: The findings highlight high receptivity
      to emerging neurotechnologies for ADHD, key areas for which parents anticipate
      support from these technologies, and ethics challenges to clinical translation in
      light of parents' salient hope and minimal consideration of risk in their pursuit
      of "anything that would help."
CI  - (c) 2012 SAGE Publications.
FAU - Borgelt, Emily L
AU  - Borgelt EL
AD  - University of British Columbia, Vancouver, Canada.
FAU - Buchman, Daniel Z
AU  - Buchman DZ
AD  - University of British Columbia, Vancouver, Canada.
FAU - Weiss, Margaret
AU  - Weiss M
AD  - University of British Columbia, Vancouver, Canada.
FAU - Illes, Judy
AU  - Illes J
AD  - University of British Columbia, Vancouver, Canada jilles@mail.ubc.ca.
LA  - eng
GR  - CIHR/INMHA CNE#85117/Canadian Institutes of Health Research/Canada
GR  - R01#MH 9R01MH84282/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120522
PL  - United States
TA  - J Atten Disord
JT  - Journal of attention disorders
JID - 9615686
SB  - IM
MH  - Attention Deficit Disorder with Hyperactivity/*diagnosis/*therapy
MH  - Child
MH  - Female
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Neuroimaging
MH  - Parents/*psychology
MH  - Perception
MH  - Qualitative Research
MH  - *Therapies, Investigational
MH  - Translational Research, Biomedical
OTO - NOTNLM
OT  - ADHD
OT  - neuroethics
OT  - neuroimaging
OT  - psychiatry
OT  - qualitative research
EDAT- 2012/05/24 06:00
MHDA- 2015/05/23 06:00
CRDT- 2012/05/24 06:00
PHST- 2012/05/24 06:00 [entrez]
PHST- 2012/05/24 06:00 [pubmed]
PHST- 2015/05/23 06:00 [medline]
AID - 1087054712445781 [pii]
AID - 10.1177/1087054712445781 [doi]
PST - ppublish
SO  - J Atten Disord. 2014 Jul;18(5):395-401. doi: 10.1177/1087054712445781. Epub 2012 
      May 22.


PMID- 22617617
OWN - NLM
STAT- MEDLINE
DCOM- 20120814
LR  - 20120523
IS  - 1873-233X (Electronic)
IS  - 0029-7844 (Linking)
VI  - 119
IP  - 6
DP  - 2012 Jun
TI  - ACOG committee opinion no. 528: Adoption.
PG  - 1320-4
LID - 10.1097/AOG.0b013e31825af411 [doi]
AB  - Obstetrician-gynecologists may find themselves at the center of adoption issues
      because of their expertise in the assessment and management of infertility,
      pregnancy, and childbirth. The lack of clarity about both ethical issues and
      legal consequences may create challenges for physicians. Therefore, the Committee
      on Ethics of the American College of Obstetricians and Gynecologists discusses
      ethical issues, proposes safeguards,and makes recommendations regarding the role 
      of the physician in adoption.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Obstet Gynecol
JT  - Obstetrics and gynecology
JID - 0401101
SB  - IM
MH  - *Adoption
MH  - Gynecology
MH  - Humans
MH  - Obstetrics
MH  - Referral and Consultation
EDAT- 2012/05/24 06:00
MHDA- 2012/08/15 06:00
CRDT- 2012/05/24 06:00
PHST- 2012/05/24 06:00 [entrez]
PHST- 2012/05/24 06:00 [pubmed]
PHST- 2012/08/15 06:00 [medline]
AID - 10.1097/AOG.0b013e31825af411 [doi]
AID - 00006250-201206000-00051 [pii]
PST - ppublish
SO  - Obstet Gynecol. 2012 Jun;119(6):1320-4. doi: 10.1097/AOG.0b013e31825af411.


PMID- 22617555
OWN - NLM
STAT- MEDLINE
DCOM- 20120925
LR  - 20120523
IS  - 1539-073X (Electronic)
IS  - 1520-9229 (Linking)
VI  - 14
IP  - 2
DP  - 2012 Apr-Jun
TI  - The hospitalized prisoner with a life-threatening illness: criminal first and
      patient second?
PG  - 43-7
LID - 10.1097/NHL.0b013e3182570904 [doi]
AB  - It is generally accepted that the Patient's Bill of Rights applies to all
      patients including prisoners. Yet, a prisoners' incarcerated status generally
      prohibits inmates from making any decision that may shorten his/her life, and as 
      such, the de facto medical decision maker becomes the medical director of the
      state correctional facility. This case study highlights the challenges that arise
      when the ethically appropriate response to a hospitalized prisoner's terminal
      medical condition warrants decisions that are in conflict with that advocated by 
      the correctional facility.
FAU - Badger, James M
AU  - Badger JM
AD  - Department of Psychiatry, Rhode Island Hospital, Providence, RI, USA.
      Jbadger@lifespan.org
FAU - Ladd, Rosalind Ekman
AU  - Ladd RE
FAU - Friedemann, Glenn R
AU  - Friedemann GR
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - JONAS Healthc Law Ethics Regul
JT  - JONA'S healthcare law, ethics and regulation
JID - 100888423
MH  - Fatal Outcome
MH  - *Hospitalization
MH  - Humans
MH  - Laryngeal Neoplasms/diagnosis/*therapy
MH  - Male
MH  - *Mental Competency
MH  - Middle Aged
MH  - Patient Rights/*ethics
MH  - Prisoners/*psychology
MH  - Tracheostomy
EDAT- 2012/05/24 06:00
MHDA- 2012/09/26 06:00
CRDT- 2012/05/24 06:00
PHST- 2012/05/24 06:00 [entrez]
PHST- 2012/05/24 06:00 [pubmed]
PHST- 2012/09/26 06:00 [medline]
AID - 10.1097/NHL.0b013e3182570904 [doi]
AID - 00128488-201204000-00003 [pii]
PST - ppublish
SO  - JONAS Healthc Law Ethics Regul. 2012 Apr-Jun;14(2):43-7. doi:
      10.1097/NHL.0b013e3182570904.


PMID- 22617087
OWN - NLM
STAT- MEDLINE
DCOM- 20121003
LR  - 20120523
IS  - 1538-1145 (Electronic)
IS  - 1527-4160 (Linking)
VI  - 18
IP  - 3
DP  - 2012 May
TI  - Clinical and ethical dilemmas in the psychiatric care of patients who border on
      the edge of being able to live safely and independently.
PG  - 213-20
LID - 10.1097/01.pra.0000415079.74238.3f [doi]
AB  - In the current economic environment and era of health care finance reform, mental
      health budgets have faced cutbacks across the nation, and they may face even
      deeper reductions in the future. Diminished funding for care of patients with
      severe psychiatric illness creates significant ethical and clinical dilemmas.
      Throughout medicine, physicians' professional virtues and obligations of
      beneficence may conflict with the need to balance respect for patient autonomy
      and deliver clinically appropriate, humane, and ethical care within a limited
      budget. This article uses a case presentation to highlight this struggle at the
      interface of psychiatry, ethics, and the emergency room in the care of people
      with severe mental illness.
FAU - Kwok, Stephanie I
AU  - Kwok SI
AD  - Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of
      Medicine, Houston, TX, USA.
FAU - Matorin, Anu A
AU  - Matorin AA
FAU - Kahn, David A
AU  - Kahn DA
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Psychiatr Pract
JT  - Journal of psychiatric practice
JID - 100901141
SB  - IM
MH  - Commitment of Mentally Ill
MH  - Emergency Services, Psychiatric/*ethics
MH  - Female
MH  - Humans
MH  - Mental Competency
MH  - Middle Aged
MH  - Patient Care Planning/*ethics
MH  - Patient Compliance
MH  - Physician-Patient Relations/*ethics
MH  - Psychotic Disorders/*rehabilitation
MH  - Social Justice
MH  - Substance-Related Disorders/*rehabilitation
MH  - United States
MH  - Virtues
EDAT- 2012/05/24 06:00
MHDA- 2012/10/04 06:00
CRDT- 2012/05/24 06:00
PHST- 2012/05/24 06:00 [entrez]
PHST- 2012/05/24 06:00 [pubmed]
PHST- 2012/10/04 06:00 [medline]
AID - 10.1097/01.pra.0000415079.74238.3f [doi]
AID - 00131746-201205000-00009 [pii]
PST - ppublish
SO  - J Psychiatr Pract. 2012 May;18(3):213-20. doi:
      10.1097/01.pra.0000415079.74238.3f.


PMID- 22617086
OWN - NLM
STAT- MEDLINE
DCOM- 20121003
LR  - 20120523
IS  - 1538-1145 (Electronic)
IS  - 1527-4160 (Linking)
VI  - 18
IP  - 3
DP  - 2012 May
TI  - Law and psychiatry. Doing forensic work, II: fees, billing, and collections.
PG  - 208-12
LID - 10.1097/01.pra.0000415078.66615.74 [doi]
AB  - Forensic practice fees, billing, and collection procedures are quite different
      from those in general psychiatry. Most forensic practices have far fewer
      "clients," and individual bills are usually larger. Collections are usually
      better (and less frequently discounted) in forensic practice, and resolving
      billing disputes is far more straightforward. Medicare, Medicaid, other insurance
      coverage, provider networks and agreements, procedure codes, and
      diagnosis-related groups (DRGs) are all largely irrelevant in forensic work
      (although sometimes important to direct clinical services in correctional
      psychiatry or forensic treatment clinics). An understanding of the practicalities
      and ethics of charging and billing for forensic services greatly simplifies
      practice management.
FAU - Reid, William H
AU  - Reid WH
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Psychiatr Pract
JT  - Journal of psychiatric practice
JID - 100901141
SB  - IM
MH  - *Accounts Payable and Receivable
MH  - *Fees and Charges
MH  - *Forensic Psychiatry
MH  - Humans
MH  - *Patient Credit and Collection
MH  - *Practice Management, Medical
MH  - United States
EDAT- 2012/05/24 06:00
MHDA- 2012/10/04 06:00
CRDT- 2012/05/24 06:00
PHST- 2012/05/24 06:00 [entrez]
PHST- 2012/05/24 06:00 [pubmed]
PHST- 2012/10/04 06:00 [medline]
AID - 10.1097/01.pra.0000415078.66615.74 [doi]
AID - 00131746-201205000-00008 [pii]
PST - ppublish
SO  - J Psychiatr Pract. 2012 May;18(3):208-12. doi:
      10.1097/01.pra.0000415078.66615.74.


PMID- 22616998
OWN - NLM
STAT- MEDLINE
DCOM- 20131122
LR  - 20130206
IS  - 1471-6712 (Electronic)
IS  - 0283-9318 (Linking)
VI  - 27
IP  - 1
DP  - 2013 Mar
TI  - Diabetes and end of life: ethical and methodological issues in gathering evidence
      to guide care.
PG  - 203-11
LID - 10.1111/j.1471-6712.2012.01016.x [doi]
AB  - INTRODUCTION: Providing palliative care for people with diabetes at the end of
      life is part of the chronic disease care trajectory, but end of life care is
      complex and the presence of diabetes further complicates management. AIM: The aim
      of the paper is to discuss the ethical and methodological issues encountered when
      undertaking research to develop guidelines for managing diabetes at the end of
      life and the strategies used to address the issues. METHOD: The issues emerged as
      we developed guidelines for managing diabetes at the end of life, which included 
      conducting individual interviews with 14 people with diabetes requiring
      palliative care and 10 family members. A reflexive researcher journal was
      maintained throughout the guideline development process. The interview
      transcripts and researcher's journal were analysed to determine key
      methodological, ethical and researcher-related issues. FINDINGS: Key themes were 
      vulnerability of the sampling population, methodological issues included
      recruiting participants and ensuring rigor, ethical issues concerned benefit and 
      risk, justice, autonomy, privacy, professional boundaries and informed consent.
      Researcher-related issues were identified such as managing participant distress
      and their own emotional distress. People were willing to discuss end of life
      diabetes management preferences. CONCLUSIONS: Undertaking research with people at
      the end of life is complex because of their vulnerability and the ethical issues 
      involved. However, the ethical principles of autonomy and justice apply and
      people should be given the relevant information and opportunity to decide whether
      to participate or not.
CI  - (c) 2012 The Authors. Scandinavian Journal of Caring Sciences (c) 2012 Nordic
      College of Caring Science.
FAU - Dunning, Trisha
AU  - Dunning T
AD  - Centre for Nursing and Allied Health Research, Deakin University and Barwon
      Health, Geelong, VIC, Australia. trisha.dunning@barwonhealth.org.au
FAU - Duggan, Nicole
AU  - Duggan N
FAU - Savage, Sally
AU  - Savage S
FAU - Martin, Peter
AU  - Martin P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120523
PL  - Sweden
TA  - Scand J Caring Sci
JT  - Scandinavian journal of caring sciences
JID - 8804206
MH  - Diabetes Mellitus/*therapy
MH  - *Ethics
MH  - *Evidence-Based Medicine
MH  - Humans
MH  - Terminal Care/*organization & administration
EDAT- 2012/05/24 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/05/24 06:00
PHST- 2012/05/24 06:00 [entrez]
PHST- 2012/05/24 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1111/j.1471-6712.2012.01016.x [doi]
PST - ppublish
SO  - Scand J Caring Sci. 2013 Mar;27(1):203-11. doi: 10.1111/j.1471-6712.2012.01016.x.
      Epub 2012 May 23.


PMID- 22616776
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121011
LR  - 20211021
IS  - 2043-9113 (Electronic)
IS  - 2043-9113 (Linking)
VI  - 2
IP  - 1
DP  - 2012 May 22
TI  - Effects of autoclaving and high pressure on allergenicity of hazelnut proteins.
PG  - 12
LID - 10.1186/2043-9113-2-12 [doi]
AB  - BACKGROUND: Hazelnut is reported as a causative agent of allergic reactions.
      However it is also an edible nut with health benefits. The allergenic
      characteristics of hazelnut-samples after autoclaving (AC) and high-pressure
      (HHP) processing have been studied and are also presented here. Previous studies 
      demonstrated that AC treatments were responsible for structural transformation of
      protein structure motifs. Thus, structural analyses of allergen proteins from
      hazelnut were carried out to observe what is occurring in relation to the
      specific-IgE recognition of the related allergenic proteins. The aims of this
      work are to evaluate the effect of AC and HHP processing on hazelnut in vitro
      allergenicity using human-sera and to analyse the complexity of hazelnut
      allergen-protein structures. METHODS: Hazelnut-samples were subjected to AC and
      HHP processing. The specific IgE- reactivity was studied in 15 allergic
      clinic-patients via western blotting analyses. A series of
      homology-based-bioinformatics 3D-models (Cora 1, Cora 8, Cora 9 and Cora 11) were
      generated for the antigens included in the study to analyse the co mplexity of
      their protein structure. This study is supported by the Declaration of Helsinki
      and subsequent ethical guidelines. RESULTS: A severe reduction in vitro in
      allergenicity to hazelnut after AC processing was observed in the allergic
      clinic-patients studied. The specific-IgE binding of some of the described
      immunoreactive hazelnut protein-bands: Cora 1 ~18KDa, Cora 8 ~9KDa, Cora 9
      ~35-40KDa and Cora 11 ~47-48 KDa decreases. Furthermore a relevant glycosylation 
      was assigned and visualized via structural analysis of proteins (3D-modelling)
      for the first time in the protein-allergen Cora 11 showing a new role which could
      open a new door for allergenicity-unravellings. CONCLUSION: Hazelnut
      allergenicity-studies in vivo via Prick-Prick and other means using AC processing
      are crucial to verify the data we observed via in vitro analyses. Glycosylation
      studies provided us with clues to elucidate, in the near future, mechanisms of
      the structures that contribute to hazelnut allergenicity, which thus, in turn,
      help alleviate food allergens.
FAU - Lopez, Elena
AU  - Lopez E
AD  - Centro de Investigacion (i + 12) del Hospital Universitario 12 de Octubre, Avda
      de Cordoba, s/n, 28041, Madrid, Spain. elena.lopez.villar@gmail.com.
FAU - Cuadrado, Carmen
AU  - Cuadrado C
FAU - Burbano, Carmen
AU  - Burbano C
FAU - Jimenez, Maria Aranzazu
AU  - Jimenez MA
FAU - Rodriguez, Julia
AU  - Rodriguez J
FAU - Crespo, Jesus F
AU  - Crespo JF
LA  - eng
PT  - Journal Article
DEP - 20120522
PL  - England
TA  - J Clin Bioinforma
JT  - Journal of clinical bioinformatics
JID - 101554637
PMC - PMC3467176
EDAT- 2012/05/24 06:00
MHDA- 2012/05/24 06:01
CRDT- 2012/05/24 06:00
PHST- 2012/02/01 00:00 [received]
PHST- 2012/05/08 00:00 [accepted]
PHST- 2012/05/24 06:00 [entrez]
PHST- 2012/05/24 06:00 [pubmed]
PHST- 2012/05/24 06:01 [medline]
AID - 2043-9113-2-12 [pii]
AID - 10.1186/2043-9113-2-12 [doi]
PST - epublish
SO  - J Clin Bioinforma. 2012 May 22;2(1):12. doi: 10.1186/2043-9113-2-12.


PMID- 22616595
OWN - NLM
STAT- MEDLINE
DCOM- 20120807
LR  - 20191112
IS  - 0006-9248 (Print)
IS  - 0006-9248 (Linking)
VI  - 113
IP  - 5
DP  - 2012
TI  - Integration of the e-Learning into the medical university curricula.
PG  - 324-30
AB  - OBJECTIVES: The aim of this contribution was to present the e-Learning
      introduction in the Slovak Medical University (SMU) with a focus on the
      implementation phase of the two blended courses - Healthcare Quality and
      Healthcare Professionals' Ethics. BACKGROUND: The introduction of the e-Learning 
      was realized during the period 2008-2009 in the partnership of SMU and IBM
      Company, following strictly the project management approach. METHODS: The
      development of the e-module beta-versions was evaluated by the modules' authors
      using a structured interview. In a consequent pilot testing, the blended courses 
      were evaluated by 23 students of the bachelor program in Rescue health care, and 
      by 61 public health students at the master level program, respectively, using the
      standardized questionnaires. RESULTS: The tangible results included the
      documented SMU strategy for the e-Learning integration, six e-Learning modules
      and evaluation results. The authors' evaluation showed high scores for the
      experience in collaboration with IBM, as well as for the experience with the LMS 
      environment. The students' evaluation showed a high acceptance of the e-Learning 
      by both part-time and full-time students. The access to Internet was not
      recognized as a serious barrier. CONCLUSION: The first experience with the
      integration of the e-Learning into the curricula of the Slovak Medical University
      showed the advantage of the systematic approach. The experience with developing
      the strategy in an interdisciplinary/ intercultural team, the knowledge about
      specific characteristics of distance learning by the involved SMU staff, and the 
      know-how and skills represented the important benefits. It was demonstrated that 
      the blended learning is recommended as optimal for the education in medical
      environment (Tab. 4, Fig. 1, Ref. 22).
FAU - Rusnakova, V
AU  - Rusnakova V
AD  - Slovak Medical University, Bratislava, Slovakia. viera.rusnakova@szu.sk
FAU - Bacharova, L
AU  - Bacharova L
FAU - Simo, J
AU  - Simo J
FAU - Krcmeryova, T
AU  - Krcmeryova T
FAU - Finka, M
AU  - Finka M
FAU - Kovac, R
AU  - Kovac R
LA  - eng
PT  - Journal Article
PL  - Slovakia
TA  - Bratisl Lek Listy
JT  - Bratislavske lekarske listy
JID - 0065324
SB  - IM
MH  - *Computer-Assisted Instruction
MH  - *Curriculum
MH  - *Education, Distance
MH  - *Education, Medical
MH  - Humans
MH  - *Internet
MH  - Slovakia
EDAT- 2012/05/24 06:00
MHDA- 2012/08/08 06:00
CRDT- 2012/05/24 06:00
PHST- 2012/05/24 06:00 [entrez]
PHST- 2012/05/24 06:00 [pubmed]
PHST- 2012/08/08 06:00 [medline]
AID - 10.4149/bll_2012_075 [doi]
PST - ppublish
SO  - Bratisl Lek Listy. 2012;113(5):324-30. doi: 10.4149/bll_2012_075.


PMID- 22616546
OWN - NLM
STAT- MEDLINE
DCOM- 20120814
LR  - 20191210
IS  - 0748-383X (Print)
IS  - 0748-383X (Linking)
VI  - 22
IP  - 1
DP  - 2012
TI  - Catching flies with vinegar: a critique of the Centers for Medicare and Medicaid 
      self-disclosure program.
PG  - 169-225
AB  - This Article argues that the current approach of the Department of Health and
      Human Services and the Centers for Medicare and Medicaid Services (CMS) to
      enforcement of the Ethics in Patient Referrals Act (the "Stark Law") is
      unnecessarily punitive and discourages health-care providers from self-disclosing
      even very minor violations of the Stark Law. This Article suggests a number of
      specific changes to encourage provider self-disclosure and proposes that CMS
      create a demonstration project under the authority of the Patient Protection and 
      Affordable Care Act to test the reforms. A demonstration project provides the
      perfect vehicle to prove that increased self-disclosure protocols for the Stark
      Law can decrease the government's costs of enforcement, improve program
      integrity, and encourage providers to deal responsibly with the inevitable minor 
      lapses in compliance that arise in such an enormous government program as
      Medicare.
FAU - Veilleux, Jean Wright
AU  - Veilleux JW
AD  - Charlotte School of Law, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Health Matrix Clevel
JT  - Health matrix (Cleveland, Ohio : 1991)
JID - 9311154
MH  - Centers for Medicare and Medicaid Services, U.S.
MH  - Disclosure/*legislation & jurisprudence
MH  - Humans
MH  - Ownership/legislation & jurisprudence
MH  - Physician Self-Referral/*legislation & jurisprudence
MH  - United States
EDAT- 2012/05/24 06:00
MHDA- 2012/08/15 06:00
CRDT- 2012/05/24 06:00
PHST- 2012/05/24 06:00 [entrez]
PHST- 2012/05/24 06:00 [pubmed]
PHST- 2012/08/15 06:00 [medline]
PST - ppublish
SO  - Health Matrix Clevel. 2012;22(1):169-225.


PMID- 22616542
OWN - NLM
STAT- MEDLINE
DCOM- 20120814
LR  - 20161125
IS  - 0748-383X (Print)
IS  - 0748-383X (Linking)
VI  - 22
IP  - 1
DP  - 2012
TI  - PGTandMe: social networking-based genetic testing and the evolving research
      model.
PG  - 33-74
AB  - The opportunity to use extensive genetic data, personal information, and family
      medical history for research purposes may be naturally appealing to the personal 
      genetic testing (PGT) industry, which is already coupling direct-to-consumer
      (DTC) products with social networking technologies, as well as to potential
      industry or institutional partners. This article evaluates the transformation in 
      research that the hybrid of PGT and social networking will bring about,
      and--highlighting the challenges associated with a new paradigm of
      "patient-driven" genomic research--focuses on the consequences of shifting the
      structure, locus, timing, and scope of research through genetic crowd-sourcing.
      This article also explores potential ethical, legal, and regulatory issues that
      arise from the hybrid between personal genomic research and online social
      networking, particularly regarding informed consent, institutional review board
      (IRB) oversight, and ownership/intellectual property (IP) considerations.
FAU - Koch, Valerie Gutmann
AU  - Koch VG
AD  - New York State Task Force on Life and the Law, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Health Matrix Clevel
JT  - Health matrix (Cleveland, Ohio : 1991)
JID - 9311154
MH  - Community Participation/legislation & jurisprudence
MH  - Genetic Privacy/ethics/legislation & jurisprudence
MH  - Genetic Research/ethics/*legislation & jurisprudence
MH  - Genetic Testing/ethics/*legislation & jurisprudence
MH  - Humans
MH  - Informed Consent/ethics/legislation & jurisprudence
MH  - Marketing of Health Services/ethics/*legislation & jurisprudence
MH  - Private Sector/ethics/legislation & jurisprudence
MH  - *Social Networking
EDAT- 2012/05/24 06:00
MHDA- 2012/08/15 06:00
CRDT- 2012/05/24 06:00
PHST- 2012/05/24 06:00 [entrez]
PHST- 2012/05/24 06:00 [pubmed]
PHST- 2012/08/15 06:00 [medline]
PST - ppublish
SO  - Health Matrix Clevel. 2012;22(1):33-74.


PMID- 22616458
OWN - NLM
STAT- MEDLINE
DCOM- 20120814
LR  - 20120523
IS  - 1259-4792 (Print)
IS  - 1259-4792 (Linking)
IP  - 265
DP  - 2012 Mar-Apr
TI  - [Information and communication technologies in pediatrics, ethical reflection].
PG  - 14-6
AB  - Information and communication technologies play an important role in the field of
      paediatrics. These aids diversify and supplement information and medical
      monitoring, and call also transform the helping relationship between the nurse
      and the child. Some areas of reflection enable these technologies to be
      approached from an ethical angle.
FAU - Dutier, Aurelien
AU  - Dutier A
AD  - Universite Paris-Descartes, Paris. aurelien.dutier@neuf.fr
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Les technologies de l'information et de la communication en pediatrie, reflexion 
      ethique.
PL  - France
TA  - Soins Pediatr Pueric
JT  - Soins. Pediatrie, puericulture
JID - 9604503
MH  - Child
MH  - *Ethics, Nursing
MH  - Humans
MH  - *Internet
MH  - *Nurse-Patient Relations
MH  - Patient Education as Topic
MH  - Telemedicine/*ethics
EDAT- 2012/05/24 06:00
MHDA- 2012/08/15 06:00
CRDT- 2012/05/24 06:00
PHST- 2012/05/24 06:00 [entrez]
PHST- 2012/05/24 06:00 [pubmed]
PHST- 2012/08/15 06:00 [medline]
PST - ppublish
SO  - Soins Pediatr Pueric. 2012 Mar-Apr;(265):14-6.


PMID- 22616365
OWN - NLM
STAT- MEDLINE
DCOM- 20120814
LR  - 20120523
IS  - 0297-2964 (Print)
IS  - 0297-2964 (Linking)
IP  - 108
DP  - 2012 Mar
TI  - [Professional values: a strategic component of health professionals. The
      contribution of decisional research at the Toulouse University Hospital Center].
PG  - 53-66
AB  - The organizational involvement concept is often developed by many researchers and
      practitioners. This study is in the right inheritance of Allen and Meyer (1990)
      and Thevenet and Neveu (2002) works who all considered the involvement as "an
      affective or emotional attachment towards the organization such as an individual 
      strongly involved identifies himself, reinforces his own agreement and enjoys
      being a member of the organization that employs him". The aim of this study was
      to demonstrate the impact of professional values (in terms of adherence to the
      purposes, norms and values of the establishment upon the subject's involvement in
      professional activities). 1538 health professionals practising in Toulouse
      academic hospital center have answered a questionnaire upon the subject's
      individual perception of his personal involvement in his workplace; the possible 
      working impacts upon his own motivation, the perceptions upon professional
      values. Results indicate that if involvement is subject to professional values,
      it turns towards a double determination: technical and axiological or ethical.
      The professional and axiological dimension introduces a moral position and a
      cognitive framework that participates in the decision-making action : working
      together, creating a climate of confidence, trusting the group, and progressing
      for greater cohesion. The ethical dimension joins historic and humanist values:
      self respect and altruism; developing human values for oneself and for others.
      Specifying values is already a project in itself, in terms of consciousness.
      Understanding those impacts upon health professionals involvements' is also the
      aim to include the historical of our Care Project in collective interaction,
      alteration and construction purposes.
FAU - Peoc'h, Nadia
AU  - Peoc'h N
AD  - Universite de Toulouse 2 - Le Mirail. Cadre superieur de sante, Direction des
      Soins des Hopitaux de Toulouse. peoch.n@chu-toulouse.fr
FAU - Ceaux, Christine
AU  - Ceaux C
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Les valeurs professionnelles, une composante de la strategie d'implication
      organisationnelle des professionnels de sante... L'apport comprehensif d'une
      recherche decisionnelle menee au CHU de Toulouse.
PL  - France
TA  - Rech Soins Infirm
JT  - Recherche en soins infirmiers
JID - 9715370
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Attitude of Health Personnel
MH  - *Decision Making
MH  - Delivery of Health Care
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Professional Practice/*standards
EDAT- 2012/05/24 06:00
MHDA- 2012/08/15 06:00
CRDT- 2012/05/24 06:00
PHST- 2012/05/24 06:00 [entrez]
PHST- 2012/05/24 06:00 [pubmed]
PHST- 2012/08/15 06:00 [medline]
PST - ppublish
SO  - Rech Soins Infirm. 2012 Mar;(108):53-66.


PMID- 22616301
OWN - NLM
STAT- MEDLINE
DCOM- 20120815
LR  - 20191210
IS  - 1320-3185 (Print)
IS  - 1320-3185 (Linking)
VI  - 19
IP  - 9
DP  - 2012 Apr
TI  - Nurses and ethical conflict with employer organisations.
PG  - 29
FAU - Johnstone, Megan-Jane
AU  - Johnstone MJ
AD  - School of Nursing and Midwifery, Deakin University, Victoria.
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Aust Nurs J
JT  - Australian nursing journal (July 1993)
JID - 9317904
MH  - *Conflict, Psychological
MH  - *Ethics, Nursing
MH  - Humans
MH  - Morals
MH  - Nursing Staff, Hospital/*ethics
MH  - *Patient Safety
MH  - *Professional Autonomy
EDAT- 2012/05/24 06:00
MHDA- 2012/08/16 06:00
CRDT- 2012/05/24 06:00
PHST- 2012/05/24 06:00 [entrez]
PHST- 2012/05/24 06:00 [pubmed]
PHST- 2012/08/16 06:00 [medline]
PST - ppublish
SO  - Aust Nurs J. 2012 Apr;19(9):29.


PMID- 22616253
OWN - NLM
STAT- MEDLINE
DCOM- 20120605
LR  - 20120523
IS  - 0026-2102 (Print)
IS  - 0026-2102 (Linking)
VI  - 94
IP  - 4
DP  - 2012 Apr
TI  - An associate's ethical dilemma.
PG  - 30
FAU - Reynolds, Steven C
AU  - Reynolds SC
AD  - stevenchas@sbcglobal.net
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Mich Dent Assoc
JT  - The Journal of the Michigan Dental Association
JID - 7505621
MH  - *Ethics, Dental
MH  - Humans
MH  - Partnership Practice, Dental/*economics/*ethics
MH  - *Professional Misconduct/ethics
EDAT- 2012/05/24 06:00
MHDA- 2012/06/06 06:00
CRDT- 2012/05/24 06:00
PHST- 2012/05/24 06:00 [entrez]
PHST- 2012/05/24 06:00 [pubmed]
PHST- 2012/06/06 06:00 [medline]
PST - ppublish
SO  - J Mich Dent Assoc. 2012 Apr;94(4):30.


PMID- 22615985
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 5
DP  - 2012
TI  - Highly sensitive in vitro methods for detection of residual undifferentiated
      cells in retinal pigment epithelial cells derived from human iPS cells.
PG  - e37342
LID - 10.1371/journal.pone.0037342 [doi]
AB  - Human induced pluripotent stem cells (hiPSCs) possess the capabilities of
      self-renewal and differentiation into multiple cell types, and they are free of
      the ethical problems associated with human embryonic stem cells (hESCs). These
      characteristics make hiPSCs a promising choice for future regenerative medicine
      research. There are significant obstacles, however, preventing the clinical use
      of hiPSCs. One of the most obvious safety issues is the presence of residual
      undifferentiated cells that have tumorigenic potential. To locate residual
      undifferentiated cells, in vivo teratoma formation assays have been performed
      with immunodeficient animals, which is both costly and time-consuming. Here, we
      examined three in vitro assay methods to detect undifferentiated cells
      (designated an in vitro tumorigenicity assay): soft agar colony formation assay, 
      flow cytometry assay and quantitative real-time polymerase chain reaction assay
      (qRT-PCR). Although the soft agar colony formation assay was unable to detect
      hiPSCs even in the presence of a ROCK inhibitor that permits survival of
      dissociated hiPSCs/hESCs, the flow cytometry assay using anti-TRA-1-60 antibody
      detected 0.1% undifferentiated hiPSCs that were spiked in primary retinal pigment
      epithelial (RPE) cells. Moreover, qRT-PCR with a specific probe and primers was
      found to detect a trace amount of Lin28 mRNA, which is equivalent to that present
      in a mixture of a single hiPSC and 5.0x10(4) RPE cells. Our findings provide
      highly sensitive and quantitative in vitro assays essential for facilitating
      safety profiling of hiPSC-derived products for future regenerative medicine
      research.
FAU - Kuroda, Takuya
AU  - Kuroda T
AD  - Division of Cellular and Gene Therapy Products, National Institute of Health
      Sciences, Tokyo, Japan.
FAU - Yasuda, Satoshi
AU  - Yasuda S
FAU - Kusakawa, Shinji
AU  - Kusakawa S
FAU - Hirata, Naoya
AU  - Hirata N
FAU - Kanda, Yasunari
AU  - Kanda Y
FAU - Suzuki, Kazuhiro
AU  - Suzuki K
FAU - Takahashi, Masayo
AU  - Takahashi M
FAU - Nishikawa, Shin-Ichi
AU  - Nishikawa S
FAU - Kawamata, Shin
AU  - Kawamata S
FAU - Sato, Yoji
AU  - Sato Y
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120517
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Lin28A protein, human)
RN  - 0 (RNA, Messenger)
RN  - 0 (RNA-Binding Proteins)
SB  - IM
MH  - Carcinogenicity Tests/*methods
MH  - Cell Differentiation
MH  - Embryonic Stem Cells/*cytology
MH  - Flow Cytometry/methods
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*cytology
MH  - RNA, Messenger/analysis
MH  - RNA-Binding Proteins/analysis/biosynthesis
MH  - Real-Time Polymerase Chain Reaction/*methods
MH  - Retinal Pigment Epithelium/*cytology
MH  - Sensitivity and Specificity
PMC - PMC3355139
EDAT- 2012/05/23 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/05/23 06:00
PHST- 2012/01/23 00:00 [received]
PHST- 2012/04/20 00:00 [accepted]
PHST- 2012/05/23 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
AID - 10.1371/journal.pone.0037342 [doi]
AID - PONE-D-12-02612 [pii]
PST - ppublish
SO  - PLoS One. 2012;7(5):e37342. doi: 10.1371/journal.pone.0037342. Epub 2012 May 17.


PMID- 22615814
OWN - NLM
STAT- MEDLINE
DCOM- 20120914
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 5
DP  - 2012
TI  - Fostering critical thinking, reasoning, and argumentation skills through
      bioethics education.
PG  - e36791
LID - 10.1371/journal.pone.0036791 [doi]
AB  - Developing a position on a socio-scientific issue and defending it using a
      well-reasoned justification involves complex cognitive skills that are
      challenging to both teach and assess. Our work centers on instructional
      strategies for fostering critical thinking skills in high school students using
      bioethical case studies, decision-making frameworks, and structured analysis
      tools to scaffold student argumentation. In this study, we examined the effects
      of our teacher professional development and curricular materials on the ability
      of high school students to analyze a bioethical case study and develop a strong
      position. We focused on student ability to identify an ethical question, consider
      stakeholders and their values, incorporate relevant scientific facts and content,
      address ethical principles, and consider the strengths and weaknesses of
      alternate solutions. 431 students and 12 teachers participated in a research
      study using teacher cohorts for comparison purposes. The first cohort received
      professional development and used the curriculum with their students; the second 
      did not receive professional development until after their participation in the
      study and did not use the curriculum. In order to assess the acquisition of
      higher-order justification skills, students were asked to analyze a case study
      and develop a well-reasoned written position. We evaluated statements using a
      scoring rubric and found highly significant differences (p<0.001) between
      students exposed to the curriculum strategies and those who were not. Students
      also showed highly significant gains (p<0.001) in self-reported interest in
      science content, ability to analyze socio-scientific issues, awareness of ethical
      issues, ability to listen to and discuss viewpoints different from their own, and
      understanding of the relationship between science and society. Our results
      demonstrate that incorporating ethical dilemmas into the classroom is one
      strategy for increasing student motivation and engagement with science content,
      while promoting reasoning and justification skills that help prepare an informed 
      citizenry.
FAU - Chowning, Jeanne Ting
AU  - Chowning JT
AD  - Northwest Association for Biomedical Research, Seattle, Washington, United States
      of America. jchowning@nwabr.org
FAU - Griswold, Joan Carlton
AU  - Griswold JC
FAU - Kovarik, Dina N
AU  - Kovarik DN
FAU - Collins, Laura J
AU  - Collins LJ
LA  - eng
GR  - R25 OD011138/OD/NIH HHS/United States
GR  - R25 RR025131/RR/NCRR NIH HHS/United States
GR  - R25OD011138/OD/NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20120511
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adolescent
MH  - Bioethics/*education
MH  - Female
MH  - Humans
MH  - Male
MH  - *Professional Competence
MH  - *Thinking
PMC - PMC3350470
EDAT- 2012/05/23 06:00
MHDA- 2012/09/15 06:00
CRDT- 2012/05/23 06:00
PHST- 2012/02/07 00:00 [received]
PHST- 2012/04/13 00:00 [accepted]
PHST- 2012/05/23 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2012/09/15 06:00 [medline]
AID - 10.1371/journal.pone.0036791 [doi]
AID - PONE-D-12-03899 [pii]
PST - ppublish
SO  - PLoS One. 2012;7(5):e36791. doi: 10.1371/journal.pone.0036791. Epub 2012 May 11.


PMID- 22615026
OWN - NLM
STAT- MEDLINE
DCOM- 20131119
LR  - 20121220
IS  - 1439-4421 (Electronic)
IS  - 0941-3790 (Linking)
VI  - 74
IP  - 12
DP  - 2012 Dec
TI  - [Restraint in hospitals - a sore point].
PG  - 812-7
LID - 10.1055/s-0032-1311630 [doi]
AB  - Restraints are used for several medical situations. Their use in restraining
      patients in psychiatric care and nursing homes is widely debated, whereas those
      in hospitals are rarely discussed. This is a particular cause of concern because 
      restraints are prescribed under various circumstances in hospitals and yet they
      have an ambivalent character because they are viewed as a custodial measure. The 
      aim of this paper is to examine the civil law legislation on restraints and
      medical reasons for employing restraints in German hospitals. I will argue that
      the use of restraints should only be performed after a thorough assessment of the
      patient and his or her wishes. As a vulnerable group, patients are dependent on
      clinical staff members, who must in all circumstances do their best to respect
      the autonomy and rights of their patients. Awareness of health-care personnel
      regarding the use of restraints should be increased and interdisciplinary
      collaboration among judges, clinicians and nurses must be bridged and enhanced in
      order to improve the flow and exchange of information on this very ethical and
      moral issue.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Bretschneider, W
AU  - Bretschneider W
AD  - Institut fur Bio- und Medizinethik, Universitat Basel, Schweiz.
      wiebke.bretschneider@unibas.ch
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Fixierungsmassnahmen in Krankenhausern - Ein wunder Punkt.
DEP - 20120521
PL  - Germany
TA  - Gesundheitswesen
JT  - Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes
      (Germany))
JID - 9204210
SB  - IM
MH  - Germany
MH  - Hospitalization/*legislation & jurisprudence
MH  - *Legislation, Hospital
MH  - Patient Isolation/*ethics/*legislation & jurisprudence
MH  - Patient Participation/*legislation & jurisprudence
MH  - Restraint, Physical/*ethics/*legislation & jurisprudence
EDAT- 2012/05/23 06:00
MHDA- 2013/11/20 06:00
CRDT- 2012/05/23 06:00
PHST- 2012/05/23 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2013/11/20 06:00 [medline]
AID - 10.1055/s-0032-1311630 [doi]
PST - ppublish
SO  - Gesundheitswesen. 2012 Dec;74(12):812-7. doi: 10.1055/s-0032-1311630. Epub 2012
      May 21.


PMID- 22614173
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 3
DP  - 2012
TI  - Palliative care for the management of chronic illness: a systematic review study 
      protocol.
LID - 10.1136/bmjopen-2012-000899 [doi]
LID - e000899 [pii]
AB  - INTRODUCTION: Chronic illnesses are marked by fluctuations and variations over
      time. Individuals with chronic illness experience pain and other symptoms that
      are not always adequately managed. Their caregivers often have to deal with
      enormous burden as the illness progresses. Palliative care can serve as an
      intervention to manage chronic illness, not just at the end of life but also in
      the early phases of illness. METHODS AND ANALYSIS: Randomised and non-randomised 
      studies will be included in the systematic review. The focus will be on
      non-cancer chronic illness. Sources of data will be from PubMed and other
      databases and will include the reference list of studies included in the
      systematic review. The primary outcome will be to assess the efficacy of
      palliative care on chronic illness. Secondary outcomes will include
      health-related quality of life, care giver burden, quality of care and
      cost-effectiveness of interventions. The study population will consist of
      patients aged 18 years or over. ETHICS AND DISSEMINATION: For purposes of privacy
      and confidentiality, the systematic review will be limited to studies with
      de-identified data. The systematic review will be published in a peer-reviewed
      journal. It will also be disseminated electronically and in print. Brief reports 
      of review findings will be disseminated directly to appropriate audiences via
      email and other modes of communication. Updates of the review will be conducted
      to inform and guide healthcare practice and policy. TRIAL REGISTRATION NUMBER:
      PROSPEROCRD42011001794.
FAU - Effiong, Andem
AU  - Effiong A
AD  - Perelman School of Medicine, University of Pennsylvania, Philadelphia,
      Pennsylvania, USA.
FAU - Effiong, Andem I
AU  - Effiong AI
LA  - eng
PT  - Journal Article
DEP - 20120521
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3358622
EDAT- 2012/05/23 06:00
MHDA- 2012/05/23 06:01
CRDT- 2012/05/23 06:00
PHST- 2012/05/23 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2012/05/23 06:01 [medline]
AID - bmjopen-2012-000899 [pii]
AID - 10.1136/bmjopen-2012-000899 [doi]
PST - epublish
SO  - BMJ Open. 2012 May 21;2(3). pii: bmjopen-2012-000899. doi:
      10.1136/bmjopen-2012-000899. Print 2012.


PMID- 22613696
OWN - NLM
STAT- MEDLINE
DCOM- 20130527
LR  - 20181202
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 4
DP  - 2013 Apr
TI  - Commentary on 'Biodefence and the production of knowledge: rethinking the
      problem'.
PG  - 207-8
LID - 10.1136/medethics-2012-100545 [doi]
AB  - Buchanan and Kelley provide a sophisticated and thoughtful critique of
      contemporary discussions of biosecurity. They provide sound critiques of American
      biodefence institutions, and the general sense of imminent threat underlying the 
      rush to fund biodefence. However, the essay consistently misrepresents the
      breadth and depth of scholarly research on the ethics and politics of biodefence.
FAU - King, Nicholas B
AU  - King NB
AD  - Biomedical Ethics Unit, McGill University, 3647 Peel St, Montreal, Quebec H3A
      1X1, Canada. nicholas.king@mcgill.ca
LA  - eng
PT  - Journal Article
PT  - Comment
DEP - 20120521
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
CON - J Med Ethics. 2013 Apr;39(4):195-204. PMID: 22194319
MH  - *Academies and Institutes
MH  - *Access to Information
MH  - Animals
MH  - Biomedical Research/*ethics
MH  - Bioterrorism/*prevention & control
MH  - *Freedom
MH  - *Government Agencies
MH  - Humans
MH  - *Knowledge
MH  - *Public Health
MH  - *Research Subjects
MH  - Security Measures/*standards
EDAT- 2012/05/23 06:00
MHDA- 2013/05/29 06:00
CRDT- 2012/05/23 06:00
PHST- 2012/05/23 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2013/05/29 06:00 [medline]
AID - medethics-2012-100545 [pii]
AID - 10.1136/medethics-2012-100545 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Apr;39(4):207-8. doi: 10.1136/medethics-2012-100545. Epub 2012
      May 21.


PMID- 22613695
OWN - NLM
STAT- MEDLINE
DCOM- 20130122
LR  - 20220716
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 9
DP  - 2012 Sep
TI  - Moral and scientific boundaries: research ethics on the Thai-Burma border.
PG  - 559-60
LID - 10.1136/medethics-2012-100582 [doi]
FAU - Parker, Michael J
AU  - Parker MJ
AD  - Department of Public Health, The Ethox Centre, University of Oxford, Oxford OX3
      7LF, UK. michael.parker@ethox.ox.ac.uk
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - 096527/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120521
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
RN  - 0 (Antimalarials)
SB  - IM
MH  - Antimalarials/*therapeutic use
MH  - Asians
MH  - Biomedical Research/*ethics
MH  - Clinical Trials as Topic/*ethics
MH  - *Ethics, Medical
MH  - *Ethics, Research
MH  - Humans
MH  - Malaria/*drug therapy
MH  - *Morals
MH  - Myanmar
MH  - Patient Selection
MH  - Refugees/psychology
MH  - Transients and Migrants/psychology
PMC - PMC3426374
EDAT- 2012/05/23 06:00
MHDA- 2013/01/23 06:00
CRDT- 2012/05/23 06:00
PHST- 2012/05/23 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2013/01/23 06:00 [medline]
AID - medethics-2012-100582 [pii]
AID - 10.1136/medethics-2012-100582 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Sep;38(9):559-60. doi: 10.1136/medethics-2012-100582. Epub
      2012 May 21.


PMID- 22613205
OWN - NLM
STAT- MEDLINE
DCOM- 20120906
LR  - 20120618
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 422
IP  - 4
DP  - 2012 Jun 15
TI  - Genetic analysis of SIRT1 gene promoter in sporadic Parkinson's disease.
PG  - 693-6
LID - 10.1016/j.bbrc.2012.05.059 [doi]
AB  - Parkinson's disease (PD) is one of the most common neurodegenerative diseases. To
      date, genetic causes and underlying molecular mechanisms for sporadic PD remain
      largely unknown. Sirtuis are highly conserved NAD-dependent class III
      deacetylases. SIRT1, the closest to yeast Sir2, has deacetylase activity and
      ADP-ribosyltransferase activity. SIRT1 gene has been connected to many cellular
      processes and implicated in human diseases, such as obesity, type 2 diabetes,
      cancer and neurodegenerative diseases. Studies in animal model have also
      associated SIRT1 with aggregation of alpha-synuclein, a critical protein in the
      PD pathogenesis. We hypothesized that the genetic variants within the regulatory 
      regions of SIRT1 gene that repress its gene expression, rather than mutations in 
      its coding region that abolish SIRT1 function, may contribute to PD as a risk
      factor. In this study, we genetically analyzed the promoter region of SIRT1 gene 
      in sporadic PD patients and ethic-matched healthy controls. Three novel
      heterozygous sequence variants, g.69644133C>G, g.69644213G>A and g.69644351G>A,
      were identified in PD patients, but in none of controls, which may alter the
      transcriptional activities of SIRT1 gene promoter, resulting in reduced SIRT1
      levels. One novel heterozygous variant, g.69644219G>A, linked with
      single-nucleotide polymorphism - g.69644217A>C (rs932658), was only found in one 
      control, which may have no functional activity. Therefore, our results suggested 
      that genetic variants within the SIRT1 gene promoter may repress SIRT1 gene
      expression, contributing to PD as a risk factor.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Zhang, Aimei
AU  - Zhang A
AD  - Division of Neurology, Jining Medical College Affiliated Hospital, Jining Medical
      College, Jining, Shandong 272029, China.
FAU - Wang, Hongen
AU  - Wang H
FAU - Qin, Xianyun
AU  - Qin X
FAU - Pang, Shuchao
AU  - Pang S
FAU - Yan, Bo
AU  - Yan B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120518
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - EC 3.5.1.- (SIRT1 protein, human)
RN  - EC 3.5.1.- (Sirtuin 1)
SB  - IM
MH  - Aged
MH  - DNA Mutational Analysis
MH  - Female
MH  - *Gene Expression Regulation
MH  - Humans
MH  - Male
MH  - Parkinson Disease/*genetics
MH  - Promoter Regions, Genetic/*genetics
MH  - Sirtuin 1/*genetics
EDAT- 2012/05/23 06:00
MHDA- 2012/09/07 06:00
CRDT- 2012/05/23 06:00
PHST- 2012/05/07 00:00 [received]
PHST- 2012/05/11 00:00 [accepted]
PHST- 2012/05/23 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2012/09/07 06:00 [medline]
AID - S0006-291X(12)00936-9 [pii]
AID - 10.1016/j.bbrc.2012.05.059 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2012 Jun 15;422(4):693-6. doi:
      10.1016/j.bbrc.2012.05.059. Epub 2012 May 18.


PMID- 22612664
OWN - NLM
STAT- MEDLINE
DCOM- 20121108
LR  - 20120712
IS  - 1574-6968 (Electronic)
IS  - 0378-1097 (Linking)
VI  - 333
IP  - 1
DP  - 2012 Aug
TI  - Lipopolysaccharide O-antigen of enterohemorrhagic Escherichia coli O157:H7 is
      required for killing both insects and mammals.
PG  - 59-68
LID - 10.1111/j.1574-6968.2012.02599.x [doi]
AB  - Studies of enterohemorrhagic Escherichia coli (EHEC) infection mechanisms using
      mammals require large numbers of animals and are both costly and associated with 
      ethical problems. Here, we evaluated the pathogenic mechanisms of EHEC in the
      silkworm model. Injection of a clinically isolated EHEC O157:H7 Sakai into either
      the silkworm hemolymph or intraperitoneal fluid of mice killed the host animals. 
      EHEC O157:H7 Sakai deletion mutants of the rfbE gene, which encodes perosamine
      synthetase, a monosaccharide component synthetase of the O-antigen, or deletion
      mutants of the waaL gene, which encodes O-antigen ligase against the lipid A-core
      region of lipopolysaccharide (LPS), had attenuated killing ability in both
      silkworms and mice. Introduction of the rfbE gene or the waaL gene into the
      respective mutants restored the killing ability in silkworms. Growth of both
      mutants was inhibited by a major antimicrobial peptide in the silkworm hemolymph,
      moricin. The viability of both mutants was decreased in swine serum. The
      bactericidal effect of swine serum against both mutants was inactivated by heat
      treatment. These findings suggest that the LPS O-antigen of EHEC O157:H7 plays an
      important defensive role against antimicrobial factors in the host body fluid and
      is thus essential to the lethal effects of EHEC in animals.
CI  - (c) 2012 Federation of European Microbiological Societies. Published by Blackwell
      Publishing Ltd. All rights reserved.
FAU - Miyashita, Atsushi
AU  - Miyashita A
AD  - Laboratory of Microbiology, Graduate School of Pharmaceutical Sciences, The
      University of Tokyo, Hongo, Tokyo, Japan.
FAU - Iyoda, Sunao
AU  - Iyoda S
FAU - Ishii, Kenichi
AU  - Ishii K
FAU - Hamamoto, Hiroshi
AU  - Hamamoto H
FAU - Sekimizu, Kazuhisa
AU  - Sekimizu K
FAU - Kaito, Chikara
AU  - Kaito C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120611
PL  - England
TA  - FEMS Microbiol Lett
JT  - FEMS microbiology letters
JID - 7705721
RN  - 0 (Adhesins, Bacterial)
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Antigens, Bacterial)
RN  - 0 (Antimicrobial Cationic Peptides)
RN  - 0 (Escherichia coli Proteins)
RN  - 0 (Insect Proteins)
RN  - 0 (O Antigens)
RN  - 0 (moricin protein, Bombyx mori)
RN  - 147094-99-3 (eaeA protein, E coli)
RN  - EC 2.6.1.- (Transaminases)
RN  - EC 5.1.3.- (Carbohydrate Epimerases)
RN  - EC 5.1.3.- (perosamine synthetase)
RN  - EC 6.1.- (Carbon-Oxygen Ligases)
RN  - EC 6.1.- (WaaL protein, E coli)
SB  - IM
MH  - Adhesins, Bacterial/genetics/metabolism
MH  - Animals
MH  - Anti-Bacterial Agents/immunology
MH  - Antigens, Bacterial/immunology
MH  - Antimicrobial Cationic Peptides/immunology
MH  - Bombyx/immunology/*microbiology
MH  - Carbohydrate Epimerases/genetics/metabolism
MH  - Carbon-Oxygen Ligases/genetics/metabolism
MH  - Disease Models, Animal
MH  - Escherichia coli Infections/*immunology/microbiology
MH  - Escherichia coli O157/genetics/growth & development/*pathogenicity
MH  - Escherichia coli Proteins/genetics/metabolism
MH  - Genes, Bacterial
MH  - Hemolymph/immunology
MH  - Hot Temperature
MH  - Insect Proteins/immunology
MH  - Lethal Dose 50
MH  - Mice
MH  - Microbial Viability
MH  - O Antigens/genetics/*toxicity
MH  - Sequence Deletion
MH  - Swine/immunology
MH  - Transaminases/genetics/metabolism
EDAT- 2012/05/23 06:00
MHDA- 2012/11/09 06:00
CRDT- 2012/05/23 06:00
PHST- 2012/04/04 00:00 [received]
PHST- 2012/05/14 00:00 [accepted]
PHST- 2012/05/23 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2012/11/09 06:00 [medline]
AID - 10.1111/j.1574-6968.2012.02599.x [doi]
PST - ppublish
SO  - FEMS Microbiol Lett. 2012 Aug;333(1):59-68. doi:
      10.1111/j.1574-6968.2012.02599.x. Epub 2012 Jun 11.


PMID- 22612457
OWN - NLM
STAT- MEDLINE
DCOM- 20131122
LR  - 20220408
IS  - 1471-6712 (Electronic)
IS  - 0283-9318 (Linking)
VI  - 27
IP  - 1
DP  - 2013 Mar
TI  - The unexpected force of acute stroke leading to patients' sudden death as
      described by nurses.
PG  - 123-30
LID - 10.1111/j.1471-6712.2012.01011.x [doi]
AB  - Stroke occurs suddenly and unexpectedly and its consequences can mean the
      difference between life and death. Research into stroke is extensive but largely 
      focused on patients who survive. The aim of the study was to describe how nurses 
      experience the patient's death and dying, when patients are afflicted by acute
      stroke and whose lives cannot be saved. The study had a descriptive design with a
      hermeneutical approach. Interviews were carried out with ten nurses in stroke
      units at three hospitals. Data were interpreted using hermeneutic textual
      interpretation based on Gadamer's philosophy. The study shows that sudden death, 
      when unexpected forces intervene in the lives of patients afflicted by acute
      stroke, was described by the main theme sudden death - the unexpected force and
      the following three sub-themes: death comes unexpectedly and without warning to
      the patient; the relatives are at the mercy of the unexpected and the nurses find
      themselves in demanding situations. The new understanding emphasizes that the
      unexpected and demanding situations the nurses are put in can be understood as
      ethical dilemmas and value conflicts because they are not free to give their time
      to preserving the dying patient's dignity and are not able to give the good care 
      they wish to. A more flexible organization could support the nurses in making use
      of the creative forces in the unexpected event which an acute stroke that leads
      to death constitutes.
CI  - (c) 2012 The Authors. Scandinavian Journal of Caring Sciences (c) 2012 Nordic
      College of Caring Science.
FAU - Rejno, Asa
AU  - Rejno A
AD  - The Sahlgrenska Academy, Institute of Health and Care Sciences, University of
      Gothenburg, Goteborg, Sweden. asa.rejno@hotmail.se
FAU - Danielson, Ella
AU  - Danielson E
FAU - von Post, Irene
AU  - von Post I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120522
PL  - Sweden
TA  - Scand J Caring Sci
JT  - Scandinavian journal of caring sciences
JID - 8804206
MH  - Acute Disease
MH  - Aged
MH  - Aged, 80 and over
MH  - *Death, Sudden
MH  - Female
MH  - Humans
MH  - *Nurses
MH  - Stroke/*mortality
EDAT- 2012/05/23 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/05/23 06:00
PHST- 2012/05/23 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1111/j.1471-6712.2012.01011.x [doi]
PST - ppublish
SO  - Scand J Caring Sci. 2013 Mar;27(1):123-30. doi: 10.1111/j.1471-6712.2012.01011.x.
      Epub 2012 May 22.


PMID- 22612420
OWN - NLM
STAT- MEDLINE
DCOM- 20131112
LR  - 20121107
IS  - 1471-6712 (Electronic)
IS  - 0283-9318 (Linking)
VI  - 26
IP  - 4
DP  - 2012 Dec
TI  - Human love--the inner essence of nursing ethics according to Estrid Rodhe. A
      study using the approach of history of ideas.
PG  - 803-10
LID - 10.1111/j.1471-6712.2012.01010.x [doi]
AB  - The aim of this study is to describe the idea pattern of nursing ethics in the
      textbook written by the Swedish nurse Estrid Rodhe (1911). The purpose is to
      increase understanding of the ideas in early written history of nursing ethics by
      using the method of history of ideas. A theoretical premise, but also a
      fascinating factor in this study, is that the ethics of one profession is always 
      contextual in relation to current period. The historical context of Rodhe's time 
      was a time of difficult societal circumstances in Europe. Nurses' work was
      demanding, but a distinctive feature was enthusiasm to develop nursing.
      Discussion of the moral issues of nursing was intense, and the characteristics of
      a good nurse consisted of being as altruistic and unselfish woman. Based on our
      analysis, the inner essence of Rodhe's idea pattern consists of human love. It is
      reflected in her ideas of calling-based altruism, virtuous woman as a personal
      reason for being a nurse and nurses' ethical duty to implementation and
      subservience. Rodhe's thinking reflects the conventions of her time. The role of 
      personal moral characteristics of nurses was highlighted and not viewed as
      separable from the professional. Her textbook represented nursing knowledge of
      ethics written by a nurse and making her a pioneer of the early written history
      of nursing in general. Understanding the past helps us comprehend current issues 
      in nursing and makes visible cultural values that form the basis for today and
      tomorrow. It also provides a possibility to observe the same fundamental features
      in spite of temporal distance. Here, the history of ideas is a beneficial and
      fruitful method to increase our understanding of nursing ethics.
CI  - (c) 2012 The Authors. Scandinavian Journal of Caring Sciences (c) 2012 Nordic
      College of Caring Science.
FAU - Kangasniemi, Mari
AU  - Kangasniemi M
AD  - Department of Nursing Science, Faculty of Health Sciences, University of Eastern 
      Finland, Kuopio, Finland. mari.kangasniemi@uef.fi
FAU - Haho, Annu
AU  - Haho A
LA  - eng
PT  - Journal Article
DEP - 20120522
PL  - Sweden
TA  - Scand J Caring Sci
JT  - Scandinavian journal of caring sciences
JID - 8804206
MH  - *Ethics, Nursing
MH  - Humans
MH  - *Love
MH  - Nurse-Patient Relations
EDAT- 2012/05/23 06:00
MHDA- 2013/11/13 06:00
CRDT- 2012/05/23 06:00
PHST- 2012/05/23 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2013/11/13 06:00 [medline]
AID - 10.1111/j.1471-6712.2012.01010.x [doi]
PST - ppublish
SO  - Scand J Caring Sci. 2012 Dec;26(4):803-10. doi: 10.1111/j.1471-6712.2012.01010.x.
      Epub 2012 May 22.


PMID- 22612196
OWN - NLM
STAT- MEDLINE
DCOM- 20120919
LR  - 20120522
IS  - 1858-554X (Print)
VI  - 5
IP  - 2
DP  - 2012 May
TI  - Informed consent for inclusion into clinical trials: a serious subject to note in
      the developing world.
PG  - 97-100
AB  - INTRODUCTION: Informed consent is a critical issue especially in conducting
      clinical trials that expose human life to medical or surgical interventions. It
      necessitates a long and complex process through which the participant is
      presented with all potential favorable and non-favorable consequences upon
      getting enrolled in the study. REVIEW: The process of taking informed consent is 
      well-understood in developed countries, with every effort taken to enhance and
      maintain the autonomy of patients and their right to make an informed choice of
      whether to participate or not. This may not be the case in the developing
      world.The information given to patients before the trial might not be properly
      developed and presented, an issue that can result in serious threat to the
      decision-making process. On the other hand, investigators should remember that
      enrolling people into a trial with no potential benefit for themselves cannot be 
      considered ethical. In the current debate, we aim to address the issue of how
      respectfully and ethically clinical research trials can be done on human subjects
      and what we can do to enhance the practice in an ethical context. CONCLUSION:
      Development of a system through which we could warrant all rights of study
      participants in all cases around the world seems far from view. However, if we
      are in doubt about the ethics of a clinical trial, we can ask ourselves: "what
      would we do, if we were in the same position our patients are in now?"
FAU - Izadi, Morteza
AU  - Izadi M
AD  - Health Research Center, Baqiyatallah University of Medical Science, Tehran, Iran.
FAU - Fazel, Mozhgan
AU  - Fazel M
FAU - Nasiri-Vanashi, Taha
AU  - Nasiri-Vanashi T
FAU - Saadat, Seyed Hasan
AU  - Saadat SH
FAU - Taheri, Saeed
AU  - Taheri S
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Sudan
TA  - Arab J Nephrol Transplant
JT  - Arab journal of nephrology and transplantation
JID - 101530790
SB  - IM
MH  - Clinical Trials as Topic/*ethics
MH  - *Developing Countries
MH  - Humans
MH  - Informed Consent/*ethics
EDAT- 2012/05/23 06:00
MHDA- 2012/09/20 06:00
CRDT- 2012/05/23 06:00
PHST- 2012/05/23 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2012/09/20 06:00 [medline]
PST - ppublish
SO  - Arab J Nephrol Transplant. 2012 May;5(2):97-100.


PMID- 22612192
OWN - NLM
STAT- MEDLINE
DCOM- 20120919
LR  - 20120522
IS  - 1858-554X (Print)
VI  - 5
IP  - 2
DP  - 2012 May
TI  - The ethical aspects of medical research.
PG  - 79-80
FAU - Elamin, Sarra
AU  - Elamin S
LA  - eng
PT  - Editorial
PL  - Sudan
TA  - Arab J Nephrol Transplant
JT  - Arab journal of nephrology and transplantation
JID - 101530790
SB  - IM
MH  - Biomedical Research/*ethics
MH  - Developing Countries
MH  - Humans
MH  - Informed Consent/*psychology
EDAT- 2012/05/23 06:00
MHDA- 2012/09/20 06:00
CRDT- 2012/05/23 06:00
PHST- 2012/05/23 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2012/09/20 06:00 [medline]
PST - ppublish
SO  - Arab J Nephrol Transplant. 2012 May;5(2):79-80.


PMID- 22611604
OWN - NLM
STAT- MEDLINE
DCOM- 20121106
LR  - 20220317
IS  - 1715-5258 (Electronic)
IS  - 0008-350X (Linking)
VI  - 58
IP  - 4
DP  - 2012 Apr
TI  - Controlling pain and reducing misuse of opioids: ethical considerations.
PG  - 381-5, e190-5
AB  - OBJECTIVE: To help family physicians achieve an ethical balance in their opioid
      prescribing practices. QUALITY OF EVIDENCE: MEDLINE was searched for
      English-language articles published between 1985 and 2011. Most available
      evidence was level III. MAIN MESSAGE: It is essential to follow practice
      guidelines when prescribing opioids, except when another course of action is
      demonstrably justified. In addition, when considering the appropriateness of an
      opioid prescription, with its many ethical implications, the decision can be
      usefully guided by the application of the ethical principles of beneficence,
      nonmaleficence, respect for autonomy, and justice. As well, it is essential to
      keep current about legal and regulatory changes and provincial electronic
      registries of opioid prescriptions. CONCLUSION: Physicians need to ensure that
      their patients' pain is properly assessed and managed. Reaching optimal pain
      control might necessitate prescribing opioids. But the obligation to provide pain
      relief needs to be balanced with an equally important responsibility not to
      expose patients to risk of addiction and not to create opportunities for drug
      diversion, trafficking, and the addiction of others. Basic ethical principles can
      provide a framework to help physicians make ethically appropriate decisions about
      opioid prescribing.
FAU - Kotalik, Jaro
AU  - Kotalik J
AD  - Northern Ontario School of Medicine, Lakehead University, Thunder Bay, Ont.
      jkotalik@lakeheadu.ca
LA  - eng
LA  - fre
PT  - Journal Article
PT  - Review
PL  - Canada
TA  - Can Fam Physician
JT  - Canadian family physician Medecin de famille canadien
JID - 0120300
RN  - 0 (Analgesics, Opioid)
SB  - IM
MH  - Analgesics, Opioid/*therapeutic use
MH  - Family Practice/*ethics
MH  - Humans
MH  - Inappropriate Prescribing/*ethics
MH  - Male
MH  - Pain Management/*adverse effects
MH  - Practice Patterns, Physicians'/*ethics
MH  - Risk Assessment
MH  - Substance-Related Disorders/*prevention & control
PMC - PMC3325448
EDAT- 2012/05/23 06:00
MHDA- 2012/11/07 06:00
CRDT- 2012/05/23 06:00
PHST- 2012/05/23 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2012/11/07 06:00 [medline]
PST - ppublish
SO  - Can Fam Physician. 2012 Apr;58(4):381-5, e190-5.


PMID- 22610726
OWN - NLM
STAT- MEDLINE
DCOM- 20121221
LR  - 20211021
IS  - 1573-3645 (Electronic)
IS  - 1041-3545 (Linking)
VI  - 33
IP  - 3
DP  - 2012 Sep
TI  - Biopiracy and the ethics of medical heritage: the case of India's traditional
      knowledge digital library'.
PG  - 175-83
LID - 10.1007/s10912-012-9179-3 [doi]
AB  - Medical humanities have a central role to play in combating biopiracy. Medical
      humanities scholars can articulate and communicate the complex structures of
      meaning and significance which human beings have invested in their ways of
      conceiving health and sickness. Such awareness of the moral significance of
      medical heritage is necessary to ongoing legal, political, and ethical debates
      regarding the status and protection of medical heritage. I use the Indian
      Traditional Knowledge Digital Library as a case study of the role of medical
      humanities in challenging biopiracy by deepening our sense of the moral value of 
      medical heritage.
FAU - Kidd, Ian James
AU  - Kidd IJ
AD  - Department of Philosophy, Durham University, 50 Old Elvet, Durham DH1 3HN, UK.
      i.j.kidd@durham.ac.uk
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Med Humanit
JT  - The Journal of medical humanities
JID - 8917478
SB  - IM
MH  - *Awareness
MH  - Curriculum
MH  - *Ethics, Medical
MH  - Health Knowledge, Attitudes, Practice
MH  - Humanities/*ethics
MH  - Humans
MH  - India
MH  - *Intellectual Property
MH  - Libraries, Digital/*ethics
MH  - Morals
EDAT- 2012/05/23 06:00
MHDA- 2012/12/22 06:00
CRDT- 2012/05/22 06:00
PHST- 2012/05/22 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2012/12/22 06:00 [medline]
AID - 10.1007/s10912-012-9179-3 [doi]
PST - ppublish
SO  - J Med Humanit. 2012 Sep;33(3):175-83. doi: 10.1007/s10912-012-9179-3.


PMID- 22610580
OWN - NLM
STAT- MEDLINE
DCOM- 20120917
LR  - 20120521
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Linking)
VI  - 879
DP  - 2012
TI  - In vitro production of enucleated red blood cells from hematopoietic stem and
      progenitor cells.
PG  - 505-12
LID - 10.1007/978-1-61779-815-3_31 [doi]
AB  - The hematopoietic stem cells that are present in bone marrow and umbilical cord
      blood are promising materials for in vitro production of red blood cells (RBCs). 
      In particular, umbilical cord blood cells are likely to be readily available
      since they are generally discarded after parturition. Provided the mother of the 
      neonate consents to the use of the umbilical cord blood, this material can
      provide a useful resource without any further complicating critical or ethical
      concerns. Here, we describe a method that does not require feeder cells but
      provides an efficient approach to the production of enucleated RBCs from the
      hematopoietic stem and progenitor cells in umbilical cord blood.
FAU - Miharada, Kenichi
AU  - Miharada K
AD  - Cell Engineering Division, RIKEN BioResource Center, Tsukuba, Ibaraki, Japan.
FAU - Nakamura, Yukio
AU  - Nakamura Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
SB  - IM
MH  - Cell Culture Techniques
MH  - Cell Proliferation
MH  - Erythrocytes/*cytology
MH  - Hematopoietic Stem Cells/*cytology
MH  - Humans
MH  - Stem Cells/*cytology
EDAT- 2012/05/23 06:00
MHDA- 2012/09/18 06:00
CRDT- 2012/05/22 06:00
PHST- 2012/05/22 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2012/09/18 06:00 [medline]
AID - 10.1007/978-1-61779-815-3_31 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2012;879:505-12. doi: 10.1007/978-1-61779-815-3_31.


PMID- 22610566
OWN - NLM
STAT- MEDLINE
DCOM- 20120917
LR  - 20181201
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Linking)
VI  - 879
DP  - 2012
TI  - Generation of functional islets from human umbilical cord and placenta derived
      mesenchymal stem cells.
PG  - 291-313
LID - 10.1007/978-1-61779-815-3_17 [doi]
AB  - Bone marrow-derived mesenchymal stem cells (BM-MSCs) have been used for
      allogeneic application in tissue engineering but have certain drawbacks.
      Therefore, mesenchymal stem cells (MSCs) derived from other adult tissue sources 
      have been considered as an alternative. The human umbilical cord and placenta are
      easily available noncontroversial sources of human tissue, which are often
      discarded as biological waste, and their collection is noninvasive. These sources
      of MSCs are not subjected to ethical constraints, as in the case of embryonic
      stem cells. MSCs derived from umbilical cord and placenta are multipotent and
      have the ability to differentiate into various cell types crossing the lineage
      boundary towards endodermal lineage. The aim of this chapter is to provide a
      detailed reproducible cookbook protocol for the isolation, propagation,
      characterization, and differentiation of MSCs derived from human umbilical cord
      and placenta with special reference to harnessing their potential towards
      pancreatic/islet lineage for utilization as a cell therapy product. We show here 
      that mesenchymal stromal cells can be extensively expanded from umbilical cord
      and placenta of human origin retaining their multilineage differentiation
      potential in vitro. Our report indicates that postnatal tissues obtained as
      delivery waste represent a rich source of mesenchymal stromal cells, which can be
      differentiated into functional islets employing three-stage protocol developed by
      our group. These islets could be used as novel in vitro model for screening
      hypoglycemics/insulin secretagogues, thus reducing animal experimentation for
      this purpose and for the future human islet transplantation programs to treat
      diabetes.
FAU - Kadam, Sachin
AU  - Kadam S
AD  - Department of Chemical Engineering, Indian Institute of Technology-Bombay,
      Mumbai, MS, India.
FAU - Govindasamy, Vijayendran
AU  - Govindasamy V
FAU - Bhonde, Ramesh
AU  - Bhonde R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
SB  - IM
MH  - Female
MH  - Humans
MH  - Islets of Langerhans/*cytology
MH  - Mesenchymal Stem Cells/*cytology
MH  - Placenta/*cytology
MH  - Pregnancy
MH  - Umbilical Cord/*cytology
EDAT- 2012/05/23 06:00
MHDA- 2012/09/18 06:00
CRDT- 2012/05/22 06:00
PHST- 2012/05/22 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2012/09/18 06:00 [medline]
AID - 10.1007/978-1-61779-815-3_17 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2012;879:291-313. doi: 10.1007/978-1-61779-815-3_17.


PMID- 22610559
OWN - NLM
STAT- MEDLINE
DCOM- 20120917
LR  - 20181201
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Linking)
VI  - 879
DP  - 2012
TI  - Assessing the potential clinical utility of transplantations of neural and
      mesenchymal stem cells for treating neurodegenerative diseases.
PG  - 147-64
LID - 10.1007/978-1-61779-815-3_10 [doi]
AB  - Treatments for neurodegenerative diseases have little impact on the long-term
      patient health. However, cellular transplants of neuroblasts derived from the
      aborted embryonic brain tissue in animal models of neurodegenerative disorders
      and in patients have demonstrated survival and functionality in the brain.
      However, ethical and functional problems due to the use of this fetal tissue
      stopped most of the clinical trials. Therefore, new cell sources were needed, and
      scientists focused on neural (NSCs) and mesenchymal stem cells (MSCs). When
      transplanted in the brain of animals with Parkinson's or Huntington's disease,
      NSCs and MSCs were able to induce partial functional recovery by promoting
      neuroprotection and immunomodulation. MSCs are more readily accessible than NSCs 
      due to sources such as the bone marrow. However, MSCs are not capable of
      differentiating into neurons in vivo where NSCs are. Thus, transplantation of
      NSCs and MSCs is interesting for brain regenerative medicine. In this chapter, we
      detail the methods for NSCs and MSCs isolation as well as the transplantation
      procedures used to treat rodent models of neurodegenerative damage.
FAU - Lescaudron, Laurent
AU  - Lescaudron L
AD  - INSERM UMR 643, Nantes, France. Laurent.Lescaudron@univ-nantes.fr
FAU - Boyer, C
AU  - Boyer C
FAU - Bonnamain, Virginie
AU  - Bonnamain V
FAU - Fink, K D
AU  - Fink KD
FAU - Leveque, X
AU  - Leveque X
FAU - Rossignol, J
AU  - Rossignol J
FAU - Nerriere-Daguin, V
AU  - Nerriere-Daguin V
FAU - Malouet, A C
AU  - Malouet AC
FAU - Lelan, F
AU  - Lelan F
FAU - Dey, N D
AU  - Dey ND
FAU - Michel-Monigadon, D
AU  - Michel-Monigadon D
FAU - Lu, M
AU  - Lu M
FAU - Neveu, I
AU  - Neveu I
FAU - von Horsten, S
AU  - von Horsten S
FAU - Naveilhan, P
AU  - Naveilhan P
FAU - Dunbar, G L
AU  - Dunbar GL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
SB  - IM
MH  - Animals
MH  - Cell Separation/methods
MH  - Cells, Cultured
MH  - Mesenchymal Stem Cells/*cytology
MH  - Neural Stem Cells/*cytology
MH  - Neurodegenerative Diseases/*therapy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Stem Cell Transplantation/*methods
EDAT- 2012/05/23 06:00
MHDA- 2012/09/18 06:00
CRDT- 2012/05/22 06:00
PHST- 2012/05/22 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2012/09/18 06:00 [medline]
AID - 10.1007/978-1-61779-815-3_10 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2012;879:147-64. doi: 10.1007/978-1-61779-815-3_10.


PMID- 22610239
OWN - NLM
STAT- MEDLINE
DCOM- 20120919
LR  - 20211021
IS  - 1529-2916 (Electronic)
IS  - 1529-2908 (Linking)
VI  - 13
IP  - 6
DP  - 2012 May 18
TI  - Immune to addiction: the ethical dimensions of vaccines against substance abuse.
PG  - 521-4
LID - 10.1038/ni.2321 [doi]
AB  - Promising advances have been made in recent years for a unique class of
      immunotherapies that use vaccination to combat substance-use disorders. Although 
      such vaccines are potentially useful for addictions, they raise a variety of
      ethical and social questions.
FAU - Young, Michael J
AU  - Young MJ
AD  - Philosophy, University of Cambridge, Cambridge, UK. mjy25@cam.ac.uk
FAU - Sisti, Dominic A
AU  - Sisti DA
FAU - Rimon-Greenspan, Hila
AU  - Rimon-Greenspan H
FAU - Schwartz, Jason L
AU  - Schwartz JL
FAU - Caplan, Arthur L
AU  - Caplan AL
LA  - eng
PT  - Journal Article
DEP - 20120518
PL  - United States
TA  - Nat Immunol
JT  - Nature immunology
JID - 100941354
RN  - 0 (Vaccines)
SB  - IM
MH  - Behavior, Addictive/immunology/*prevention & control
MH  - Cocaine-Related Disorders/immunology/*prevention & control
MH  - Humans
MH  - Vaccination/*ethics
MH  - Vaccines/*administration & dosage/*immunology
EDAT- 2012/05/23 06:00
MHDA- 2012/09/20 06:00
CRDT- 2012/05/22 06:00
PHST- 2012/05/22 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2012/09/20 06:00 [medline]
AID - ni.2321 [pii]
AID - 10.1038/ni.2321 [doi]
PST - epublish
SO  - Nat Immunol. 2012 May 18;13(6):521-4. doi: 10.1038/ni.2321.


PMID- 22610186
OWN - NLM
STAT- MEDLINE
DCOM- 20120713
LR  - 20191210
IS  - 1530-0293 (Electronic)
IS  - 0090-3493 (Linking)
VI  - 40
IP  - 6
DP  - 2012 Jun
TI  - Using standardized family members to teach communication skills and ethical
      principles to critical care trainees.
PG  - 1814-9
LID - 10.1097/CCM.0b013e31824e0fb7 [doi]
AB  - OBJECTIVE: We sought to determine the effectiveness of standardized family
      members for improving communication skills and ethical and legal knowledge of
      senior intensive care unit trainees. DESIGN: Multimodal evaluation of
      mixed-methods educational intervention. SETTING: Postgraduate critical care
      medicine academic program. SUBJECTS: Postgraduate subspecialty critical care
      medicine trainees. INTERVENTION: Communication workshop featuring a short
      didactic session and four simulated family meetings using trained professionals
      as standardized family members. MEASUREMENTS: Ethical and legal knowledge and
      comfort with communication (before and after the workshop) and communication
      skill (during the workshop). MAIN RESULTS: Fifty-one postgraduate critical care
      medicine subspecialty trainees participated in the workshop over a 5-yr period.
      Ethical and legal knowledge and comfort scores improved significantly among
      trainees who participated in the workshop. Ninety percent of trainees felt that
      the workshop had met or exceeded their expectations and would recommend it to
      other trainees. Ninety-eight percent of trainees felt that the workshop had met
      the highest priority learning objectives they identified. Communication scores
      showed a trend towards improvement over the course of the workshop, although the 
      improvements were not significant. Participants reflecting on the workshop >1 yr 
      later overwhelmingly felt that it had prepared them for real communication
      challenges in training and practice. CONCLUSIONS: This workshop was effective for
      improving ethical and legal knowledge and comfort with communication among
      critical care medicine trainees. Participants overwhelmingly felt that it had met
      their learning needs and that it was an effective teaching tool that had prepared
      them for real communication challenges in training and practice. It could be used
      in a variety of contexts to address an often-neglected area of education.
FAU - Downar, James
AU  - Downar J
AD  - Faculty of Medicine, University of Toronto, Ontario, Canada.
      james.downar@utoronto.ca
FAU - Knickle, Kerry
AU  - Knickle K
FAU - Granton, John T
AU  - Granton JT
FAU - Hawryluck, Laura
AU  - Hawryluck L
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Crit Care Med
JT  - Critical care medicine
JID - 0355501
SB  - IM
CIN - Crit Care Med. 2012 Jun;40(6):1978-80. PMID: 22610211
MH  - *Attitude of Health Personnel
MH  - Clinical Competence
MH  - *Communication
MH  - *Critical Care/ethics/legislation & jurisprudence
MH  - Education, Medical, Graduate/*methods
MH  - *Family
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Intensive Care Units
MH  - Male
MH  - Needs Assessment
MH  - *Professional-Family Relations
MH  - Program Evaluation
MH  - Self Efficacy
MH  - Students, Medical/*psychology
EDAT- 2012/05/23 06:00
MHDA- 2012/07/14 06:00
CRDT- 2012/05/22 06:00
PHST- 2012/05/22 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2012/07/14 06:00 [medline]
AID - 10.1097/CCM.0b013e31824e0fb7 [doi]
AID - 00003246-201206000-00017 [pii]
PST - ppublish
SO  - Crit Care Med. 2012 Jun;40(6):1814-9. doi: 10.1097/CCM.0b013e31824e0fb7.


PMID- 22610110
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20220330
IS  - 1538-8654 (Electronic)
IS  - 1527-7941 (Linking)
VI  - 25
IP  - 6
DP  - 2012 Jun
TI  - Reliability and predictive validity of Inlow's 60-Second Diabetic Foot Screen
      Tool.
PG  - 261-6
LID - 10.1097/01.ASW.0000415343.45178.91 [doi]
AB  - OBJECTIVE: : The purpose of this study was to assess Inlow's 60-Second Diabetic
      Foot Screen Tool to ascertain consistency of risk recognition for development of 
      ulceration independent of specific assessor and practice setting. Screening tools
      that assist clinicians in identifying risk require validation. The objectives
      were to determine the intrarater reliability, interrater reliability, and
      predictive validity of Inlow's 60-Second Diabetic Foot Screen Tool in 2
      healthcare settings. DESIGN: : Following ethics board approval, a prospective
      observational study was completed. SETTING AND PARTICIPANTS: : A convenience
      sample of 69 persons with diabetes was recruited: n = 26 from an acute care
      setting (dialysis) and n = 43 from long-term-care (LTC) setting. MAIN OUTCOME
      MEASURES: : The screening tool was administered by 2 assessors independently to
      determine interrater reliability and later the same day by one of the assessors
      to determine intrarater reliability. Occurrence of foot ulcers or amputation was 
      noted 1 to 5 months later to determine predictive validity. MAIN RESULTS: :
      Reliability is reported per setting using the intraclass correlation coefficient 
      (2.1) and 95% confidence intervals. Intrarater reliability: LTC 0.96 (0.93-0.98) 
      right foot, 0.97 (0.95-0.98) left foot; dialysis 1.00 right and 1.00 left foot.
      Interrater reliability: LTC 0.92 (0.86-0.96) right foot, 0.93 (0.87-0.96) left
      foot; dialysis 0.83 (0.65-0.92) right foot and left foot. Predictive validity:
      Two subjects had events-1 ulcer and 1 amputation-that were associated with high
      Inlow's screening tool scores. CONCLUSION: : This study demonstrates excellent
      interrater and intrarater reliability and provides preliminary information about 
      predictive validity.
FAU - Murphy, Christine Anne
AU  - Murphy CA
AD  - The Ottawa Hospital, Ottawa, Ontario, Canada.
FAU - Laforet, Karen
AU  - Laforet K
FAU - Da Rosa, Paulo
AU  - Da Rosa P
FAU - Tabamo, Fruan
AU  - Tabamo F
FAU - Woodbury, M Gail
AU  - Woodbury MG
LA  - eng
PT  - Journal Article
PT  - Validation Study
PL  - United States
TA  - Adv Skin Wound Care
JT  - Advances in skin & wound care
JID - 100911021
MH  - Acute Disease
MH  - Aged
MH  - Aged, 80 and over
MH  - Confidence Intervals
MH  - Diabetic Foot/*diagnosis/pathology
MH  - Female
MH  - *Health Status Indicators
MH  - Humans
MH  - Long-Term Care
MH  - Male
MH  - Middle Aged
MH  - Multiphasic Screening/*instrumentation/methods
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Reproducibility of Results
MH  - Risk
MH  - Statistics as Topic
MH  - Time Factors
EDAT- 2012/05/23 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/05/22 06:00
PHST- 2012/05/22 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
AID - 10.1097/01.ASW.0000415343.45178.91 [doi]
AID - 00129334-201206000-00007 [pii]
PST - ppublish
SO  - Adv Skin Wound Care. 2012 Jun;25(6):261-6. doi:
      10.1097/01.ASW.0000415343.45178.91.


PMID- 22609908
OWN - NLM
STAT- MEDLINE
DCOM- 20120914
LR  - 20211021
IS  - 1532-6535 (Electronic)
IS  - 0009-9236 (Linking)
VI  - 91
IP  - 6
DP  - 2012 Jun
TI  - Healthy volunteer registries and ethical research principles.
PG  - 965-8
LID - 10.1038/clpt.2012.32 [doi]
AB  - The dual enrolling of phase I volunteers is a potential risk to subjects. It can 
      also distort study results, threaten study validity, and possibly cause harm to
      future patients. Existing subject registries differ in structure, funding, and
      governance. Although the choice of the ideal system is driven by the scope of the
      risk and the funding mechanism, and is ultimately a value judgment of freedom
      versus paternalism, none of the registries significantly impinges on the tenets
      of ethically based research.
FAU - Kupetsky-Rincon, E A
AU  - Kupetsky-Rincon EA
AD  - Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson
      University, Philadelphia, Pennsylvania, USA.
FAU - Kraft, W K
AU  - Kraft WK
LA  - eng
GR  - K30 RR022299/RR/NCRR NIH HHS/United States
GR  - T32 GM008562/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Clin Pharmacol Ther
JT  - Clinical pharmacology and therapeutics
JID - 0372741
SB  - IM
MH  - Altruism
MH  - Costs and Cost Analysis
MH  - *Ethics, Research
MH  - Humans
MH  - Motivation
MH  - Personal Autonomy
MH  - Registries/*ethics
MH  - Research Subjects/psychology/*supply & distribution
MH  - Risk Assessment
PMC - PMC5164923
MID - NIHMS834569
COIS- The authors declared no conflict of interest.
EDAT- 2012/05/23 06:00
MHDA- 2012/09/15 06:00
CRDT- 2012/05/22 06:00
PHST- 2012/05/22 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2012/09/15 06:00 [medline]
AID - clpt201232 [pii]
AID - 10.1038/clpt.2012.32 [doi]
PST - ppublish
SO  - Clin Pharmacol Ther. 2012 Jun;91(6):965-8. doi: 10.1038/clpt.2012.32.


PMID- 22609176
OWN - NLM
STAT- MEDLINE
DCOM- 20121024
LR  - 20161125
IS  - 1877-0568 (Electronic)
IS  - 1877-0568 (Linking)
VI  - 98
IP  - 4
DP  - 2012 Jun
TI  - Is it worth fixing proximal humeral fractures at increased vascular risk?
PG  - 383-9
LID - 10.1016/j.otsr.2012.01.008 [doi]
AB  - OBJECTIVE: To evaluate fixation of proximal humeral fractures by anterograde
      nailing, in terms of fracture reduction, bone healing; osteonecrosis; functional 
      consequences of osteonecrosis and malunion. DESIGN: Prospective, consecutive,
      multicenter based. SETTING: Academic Trauma Centers; approval was received from
      the ethics committee of the institutions involved in the study. METHODS:
      Fifty-one patients were enrolled prospectively, with 31 3-part and 20 4-part
      displaced fractures (head displacement greater than 45 degrees , tuberosity-head 
      gap greater than 10mm, diaphyseal gap greater than 10mm). A Telegraph nail (FH
      Orthopedics, Heimsbrunn, France) was the fixation device used, introduced through
      a superolateral transdeltoid approach under fluoroscopic guidance. The assessment
      included Simple Shoulder Test, absolute Constant score, X-rays every 3 months and
      CT-scan at final evaluation. Twelve patients died and one was lost to follow-up. 
      Immediate complications included secondary displacement in four patients.
      RESULTS: There were no infections, no deltoid muscle or axillary nerve damage,
      and all the fractures united. After a mean follow-up of 24.1 months, malunion was
      observed in 29% of the remaining 38 patients and osteonecrosis in 32%. Both
      complications were more frequent and extensive in patients with 4-part fractures.
      The osteonecrosis area influenced the Constant score, which was 55.8 points when 
      the area was less than 30%, 50.6 points between 30 and 50%, and 38 points when
      larger than 50%. Head malunion affected the Simple Shoulder Test and the Constant
      score. CONCLUSION: Nailing may thus be recommended for 3-part fractures, because 
      osteonecrosis is less frequent, more focused, and better tolerated in this
      sub-group. In contrast, antegrade nailing was not more beneficial than other
      internal fixation techniques for preventing osteonecrosis or head malunion in
      patients with 4-part fractures. LEVEL OF EVIDENCE: Level IV: prospective study.
CI  - Copyright (c) 2012 Elsevier Masson SAS. All rights reserved.
FAU - Thomazeau, H
AU  - Thomazeau H
AD  - Department of Orthopaedics and Traumatology, Clinical Epidemiology and Biometry
      research unit, Regional Hospital Center, Rennes-1 University, 2, rue
      Henri-Le-Guilloux, 35033 Rennes, France. herve.thomazeau@chu-rennes.fr
FAU - Richou, J
AU  - Richou J
FAU - Benkalfalte, T
AU  - Benkalfalte T
FAU - Kerhousse, G
AU  - Kerhousse G
FAU - Le Nen, D
AU  - Le Nen D
FAU - Veillard, D
AU  - Veillard D
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20120518
PL  - France
TA  - Orthop Traumatol Surg Res
JT  - Orthopaedics & traumatology, surgery & research : OTSR
JID - 101494830
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Bone Nails
MH  - Female
MH  - Fluoroscopy
MH  - Fracture Fixation, Internal/instrumentation/*methods
MH  - Fractures, Malunited/diagnostic imaging/*surgery
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Osteonecrosis/epidemiology
MH  - Postoperative Complications/epidemiology
MH  - Prospective Studies
MH  - Shoulder Fractures/diagnostic imaging/*surgery
MH  - Statistics, Nonparametric
MH  - Tomography, X-Ray Computed
MH  - Treatment Outcome
MH  - Vascular System Injuries/epidemiology
EDAT- 2012/05/23 06:00
MHDA- 2012/10/25 06:00
CRDT- 2012/05/22 06:00
PHST- 2011/10/13 00:00 [received]
PHST- 2012/01/05 00:00 [revised]
PHST- 2012/01/20 00:00 [accepted]
PHST- 2012/05/22 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2012/10/25 06:00 [medline]
AID - S1877-0568(12)00055-2 [pii]
AID - 10.1016/j.otsr.2012.01.008 [doi]
PST - ppublish
SO  - Orthop Traumatol Surg Res. 2012 Jun;98(4):383-9. doi: 10.1016/j.otsr.2012.01.008.
      Epub 2012 May 18.


PMID- 22608694
OWN - NLM
STAT- MEDLINE
DCOM- 20130225
LR  - 20120904
IS  - 1885-1398 (Electronic)
IS  - 1699-258X (Linking)
VI  - 8
IP  - 5
DP  - 2012 Sep-Oct
TI  - Medical ethics, research and the pharmaceutical industry.
PG  - 233-5
FAU - Abud-Mendoza, Carlos
AU  - Abud-Mendoza C
LA  - eng
PT  - Editorial
DEP - 20120517
PL  - Spain
TA  - Reumatol Clin
JT  - Reumatologia clinica
JID - 101293923
SB  - IM
MH  - Attitude of Health Personnel
MH  - Biomedical Research/ethics
MH  - Clinical Trials as Topic/economics/*ethics
MH  - Conflict of Interest
MH  - Drug Approval/economics
MH  - Drug Costs
MH  - Drug Industry/economics/*ethics
MH  - Education, Medical, Continuing/economics
MH  - Humans
MH  - Marketing/ethics
MH  - Physicians/*psychology
EDAT- 2012/05/23 06:00
MHDA- 2013/02/26 06:00
CRDT- 2012/05/22 06:00
PHST- 2011/10/10 00:00 [received]
PHST- 2011/11/15 00:00 [revised]
PHST- 2011/12/20 00:00 [accepted]
PHST- 2012/05/22 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2013/02/26 06:00 [medline]
AID - S1699-258X(12)00028-9 [pii]
AID - 10.1016/j.reuma.2011.12.010 [doi]
PST - ppublish
SO  - Reumatol Clin. 2012 Sep-Oct;8(5):233-5. doi: 10.1016/j.reuma.2011.12.010. Epub
      2012 May 17.


PMID- 22608298
OWN - NLM
STAT- MEDLINE
DCOM- 20130318
LR  - 20121015
IS  - 1873-7862 (Electronic)
IS  - 0924-977X (Linking)
VI  - 22
IP  - 11
DP  - 2012 Nov
TI  - Placebo, a historical perspective.
PG  - 770-4
LID - 10.1016/j.euroneuro.2012.04.003 [doi]
LID - S0924-977X(12)00099-5 [pii]
AB  - Substances and interventions with no specific therapeutic effect have been in use
      since the dawn of history. The term placebo has first been mentioned in the
      Scriptures, but it was not until the 19th century that it appeared in a medical
      context. Although lay people like Voltaire, and physicians such as Sir William
      Osler, have raised the possibility that much of what physicians did had no
      specific therapeutic effect, this notion was not shared by the public at large or
      by the medical profession. It was only by the end of the 18th century that a
      placebo-controlled trial has been conducted, repudiating the therapeutic effect
      of mesmerism. The advent, in the late 1940s, of effective treatments, which also 
      had serious adverse effects, made the distinction between placebo and putative,
      active drug effects more relevant and urgent, and cleared the way for
      double-blind, randomized, placebo-controlled trials. This in turn triggered an
      ethical debate on the use of placebo, both in research and in clinical practice. 
      Anthropologists, sociologists, physiologists, and medical researchers are all
      focusing their efforts on understanding the mechanism, role and modulating
      factors of placebo.
CI  - Copyright (c) 2012 Elsevier B.V. and ECNP. All rights reserved.
FAU - Czerniak, Efrat
AU  - Czerniak E
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
FAU - Davidson, Michael
AU  - Davidson M
LA  - eng
PT  - Historical Article
PT  - Journal Article
DEP - 20120518
PL  - Netherlands
TA  - Eur Neuropsychopharmacol
JT  - European neuropsychopharmacology : the journal of the European College of
      Neuropsychopharmacology
JID - 9111390
RN  - 0 (Placebos)
SB  - IM
MH  - Controlled Clinical Trials as Topic/ethics/*history/psychology
MH  - History, 16th Century
MH  - History, 17th Century
MH  - History, 18th Century
MH  - History, 19th Century
MH  - History, 20th Century
MH  - History, 21st Century
MH  - History, Ancient
MH  - Humans
MH  - Placebo Effect
MH  - Placebos/adverse effects/*history/therapeutic use
MH  - Psychopharmacology/history/methods
EDAT- 2012/05/23 06:00
MHDA- 2013/03/19 06:00
CRDT- 2012/05/22 06:00
PHST- 2011/09/06 00:00 [received]
PHST- 2012/03/22 00:00 [revised]
PHST- 2012/04/06 00:00 [accepted]
PHST- 2012/05/22 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2013/03/19 06:00 [medline]
AID - S0924-977X(12)00099-5 [pii]
AID - 10.1016/j.euroneuro.2012.04.003 [doi]
PST - ppublish
SO  - Eur Neuropsychopharmacol. 2012 Nov;22(11):770-4. doi:
      10.1016/j.euroneuro.2012.04.003. Epub 2012 May 18.


PMID- 22607813
OWN - NLM
STAT- MEDLINE
DCOM- 20121004
LR  - 20220419
IS  - 1873-4111 (Electronic)
IS  - 0378-5122 (Linking)
VI  - 72
IP  - 3
DP  - 2012 Jul
TI  - Reminiscence therapy in dementia: a review.
PG  - 203-5
LID - 10.1016/j.maturitas.2012.04.008 [doi]
AB  - Dementia is a progressive disorder that impacts several cognitive functions.
      However, some aspects of cognitive function are preserved until late in the
      disease and can therefore be the targets of specific interventions. The
      rehabilitation of cognitive function disorders represents an expanding area of
      neurological rehabilitation, and it has recently attracted growing political,
      social and ethical attention. Here, we review the efficacy of reminiscence
      therapy to improve cognitive functions and/or mood. Available studies suggest
      that reminiscence therapy can improve mood and some cognitive abilities. Further 
      studies, based on larger patient samples including placebo and control
      conditions, should be conducted to identify the optimal conditions for such
      treatment protocols.
CI  - Copyright (c) 2012. Published by Elsevier Ireland Ltd.
FAU - Cotelli, Maria
AU  - Cotelli M
AD  - IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
      mcotelli@fatebenefratelli.it
FAU - Manenti, Rosa
AU  - Manenti R
FAU - Zanetti, Orazio
AU  - Zanetti O
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120516
PL  - Ireland
TA  - Maturitas
JT  - Maturitas
JID - 7807333
SB  - IM
MH  - *Affect
MH  - *Cognition
MH  - Cognition Disorders/*rehabilitation
MH  - Dementia/complications/*therapy
MH  - Humans
MH  - *Memory
MH  - *Psychotherapy
EDAT- 2012/05/23 06:00
MHDA- 2012/10/05 06:00
CRDT- 2012/05/22 06:00
PHST- 2012/04/16 00:00 [received]
PHST- 2012/04/21 00:00 [accepted]
PHST- 2012/05/22 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2012/10/05 06:00 [medline]
AID - S0378-5122(12)00154-5 [pii]
AID - 10.1016/j.maturitas.2012.04.008 [doi]
PST - ppublish
SO  - Maturitas. 2012 Jul;72(3):203-5. doi: 10.1016/j.maturitas.2012.04.008. Epub 2012 
      May 16.


PMID- 22607776
OWN - NLM
STAT- MEDLINE
DCOM- 20131031
LR  - 20161020
IS  - 1469-5111 (Electronic)
IS  - 1461-1457 (Linking)
VI  - 16
IP  - 3
DP  - 2013 Apr
TI  - Consent in psychiatric biobanks for pharmacogenetic research.
PG  - 677-82
LID - 10.1017/S146114571200048X [doi]
AB  - In psychiatric practice, pharmacogenetics has the potential to identify patients 
      with an increased risk of unsatisfactory drug responses. Genotype-guided
      treatment adjustments may increase benefits and reduce harm in these patients;
      however, pharmacogenetic testing is not (yet) common practice and more
      pharmacogenetic research in psychiatric patients is warranted. An important
      precondition for this type of research is the establishment of biobanks. In this 
      paper, we argue that, for the storage of samples in psychiatric biobanks, waiving
      of consent is not ethically justifiable since the risks cannot be considered
      minimal and the argument of impracticability does not apply. An opt-out consent
      procedure is also not justifiable, since it presumes competence while the
      decisional competence of psychiatric patients needs to be carefully evaluated. We
      state that an enhanced opt-in consent procedure is ethically necessary, i.e. a
      procedure that supports the patients' decision-making at the time when the
      patient is most competent. Nevertheless, such a procedure is not the traditional 
      exhaustive informed consent procedure, since this is not feasible in the case of 
      biobanking.
FAU - van der Baan, Frederieke H
AU  - van der Baan FH
AD  - Department of Epidemiology, Julius Center for Health Sciences and Primary Care,
      University Medical Center Utrecht, The Netherlands. F.vanderbaan@umcutrecht.nl
FAU - Bernabe, Rose D C
AU  - Bernabe RD
FAU - Bredenoord, Annelien L
AU  - Bredenoord AL
FAU - Gregoor, Jochem G
AU  - Gregoor JG
FAU - Meynen, Gerben
AU  - Meynen G
FAU - Knol, Mirjam J
AU  - Knol MJ
FAU - van Thiel, Ghislaine J M W
AU  - van Thiel GJ
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120521
PL  - England
TA  - Int J Neuropsychopharmacol
JT  - The international journal of neuropsychopharmacology
JID - 9815893
SB  - IM
MH  - Adult
MH  - Biological Specimen Banks/*ethics/trends
MH  - Biomedical Research/*ethics/trends
MH  - Female
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Mental Disorders/diagnosis/drug therapy/*genetics
MH  - Pharmacogenetics/*ethics/trends
EDAT- 2012/05/23 06:00
MHDA- 2013/11/01 06:00
CRDT- 2012/05/22 06:00
PHST- 2012/05/22 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2013/11/01 06:00 [medline]
AID - S146114571200048X [pii]
AID - 10.1017/S146114571200048X [doi]
PST - ppublish
SO  - Int J Neuropsychopharmacol. 2013 Apr;16(3):677-82. doi:
      10.1017/S146114571200048X. Epub 2012 May 21.


PMID- 22607747
OWN - NLM
STAT- MEDLINE
DCOM- 20121011
LR  - 20161125
IS  - 1873-5347 (Electronic)
IS  - 0277-9536 (Linking)
VI  - 75
IP  - 4
DP  - 2012 Aug
TI  - IVF policy and global/local politics: the making of multiple-embryo transfer
      regulation in Taiwan.
PG  - 725-32
LID - 10.1016/j.socscimed.2012.03.050 [doi]
AB  - This paper analyzes the regulatory trajectory of multiple-embryo transfer in
      in-vitro fertilization (IVF) in Taiwan. Taking a latecomer to policy-making as
      the case, it argues the importance of conceptualizing the global/local dynamics
      in policy-making for assisted reproductive technology (ART). The conceptual
      framework is built upon recent literature on standardization, science policy, and
      global assemblage. I propose three interrelated features that reveal the "global 
      in the local": (1) the power relationships among stakeholders, (2) the selected
      global form that involved actors drew upon, and (3) the re-contextualized
      assemblage made of local networks. Data included archives, interviews, and
      participant observation. In different historical periods the specific
      stakeholders selected different preferred global forms for Taiwan, such as
      Britain's code of ethics in the 1990s, the American guideline in the early 2000s,
      and the European trend in the mid-2000s. The global is heterogeneous. The failure
      to transfer the British regulation, the revision of the American guideline by
      adding one more embryo than it specified, and the gap between the cited European 
      trend and the "no more than four" in Taiwan's 2007 Human Reproduction Law all
      show that the local network further transforms the selected global form,
      confining it to rhetoric only or tailoring it to local needs. Overall, Taiwanese 
      practitioners successfully maintained their medical autonomy to build a 'flexible
      standardization'. Multiple pregnancy remains the most common health risk of IVF
      in Taiwan.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Wu, Chia-Ling
AU  - Wu CL
AD  - Department of Sociology, National Taiwan University, Taipei 106, Taiwan, ROC.
      clwu@ntu.edu.tw
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120507
PL  - England
TA  - Soc Sci Med
JT  - Social science & medicine (1982)
JID - 8303205
SB  - IM
MH  - Embryo Transfer/methods/*standards
MH  - Female
MH  - *Fertilization in Vitro
MH  - *Health Policy
MH  - Humans
MH  - *Internationality
MH  - Models, Theoretical
MH  - Policy Making
MH  - *Politics
MH  - Practice Guidelines as Topic
MH  - Pregnancy
MH  - Pregnancy, Multiple
MH  - Taiwan
MH  - United Kingdom
MH  - United States
EDAT- 2012/05/23 06:00
MHDA- 2012/10/12 06:00
CRDT- 2012/05/22 06:00
PHST- 2011/07/08 00:00 [received]
PHST- 2012/03/20 00:00 [revised]
PHST- 2012/03/22 00:00 [accepted]
PHST- 2012/05/22 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2012/10/12 06:00 [medline]
AID - S0277-9536(12)00348-6 [pii]
AID - 10.1016/j.socscimed.2012.03.050 [doi]
PST - ppublish
SO  - Soc Sci Med. 2012 Aug;75(4):725-32. doi: 10.1016/j.socscimed.2012.03.050. Epub
      2012 May 7.


PMID- 22607726
OWN - NLM
STAT- MEDLINE
DCOM- 20130712
LR  - 20220316
IS  - 1471-2407 (Electronic)
IS  - 1471-2407 (Linking)
VI  - 12
DP  - 2012 May 17
TI  - Does access to a colorectal cancer screening website and/or a nurse-managed
      telephone help line provided to patients by their family physician increase fecal
      occult blood test uptake?: A pragmatic cluster randomized controlled trial study 
      protocol.
PG  - 182
LID - 10.1186/1471-2407-12-182 [doi]
AB  - BACKGROUND: Fecal occult blood test screening in Canada is sub-optimal. Family
      physicians play a central role in screening and are limited by the time
      constraints of clinical practice. Patients face multiple barriers that further
      reduce completion rates. Tools that support family physicians in providing their 
      patients with colorectal cancer information and that support uptake may prove
      useful. The primary objective of the study is to evaluate the efficacy of a
      patient decision aid (nurse-managed telephone support line and/or colorectal
      cancer screening website) distributed by community-based family physicians, in
      improving colorectal cancer screening rates. Secondary objectives include
      evaluation of (dis)incentives to patient FOBT uptake and internet use among 50 to
      74 year old males and females for health-related questions. Challenges faced by
      family physicians in engaging in collaborative partnerships with primary
      healthcare researchers will be documented. METHODS/DESIGN: A pragmatic, two-arm, 
      randomized cluster controlled trial conducted in 22 community-based family
      practice clinics (36 clusters) with 76 fee-for-service family physicians in
      Winnipeg, Manitoba, Canada. Each physician will enroll 30 patients attending
      their periodic health examination and at average risk for colorectal cancer. All 
      physicians will follow their standard clinical practice for screening.
      Intervention group physicians will provide a fridge magnet to each patient that
      contains information facilitating access to the study-specific colorectal cancer 
      screening decision aids (telephone help-line and website). The primary endpoint
      is patient fecal occult blood test completion rate after four months (intention
      to treat model). Multi-level analysis will include clinic, physician and patient 
      level variables. Patient Personal Health Identification Numbers will be collected
      from those providing consent to facilitate analysis of repeat screening behavior.
      Secondary outcome data will be obtained through the Clinic Characterization Form,
      Patient Tracking Form, In-Clinic Patient Survey, Post-Study Follow-Up Patient
      Survey, and Family Physician Survey. Study protocol approved by The University of
      Manitoba Health Research Ethics Board. DISCUSSION: The study intervention has the
      potential to increase patient fecal occult blood test uptake, decrease colorectal
      cancer mortality and morbidity, and improve the health of Manitobans. If
      utilization of the website and/or telephone support line result in clinically
      significant increases in colorectal cancer screening uptake, changes in screening
      at the policy- and system-level may be warranted. TRIAL REGISTRATION: Clinical
      trials.gov identifier NCT01026753.
FAU - Clouston, Kathleen
AU  - Clouston K
AD  - Department of Family Medicine Research, Faculty of Medicine, University of
      Manitoba, P228-770, Bannatyne Ave, Winnipeg, MB R3E 0W3, Canada.
      kclousto@cc.umanitoba.ca
FAU - Katz, Alan
AU  - Katz A
FAU - Martens, Patricia J
AU  - Martens PJ
FAU - Sisler, Jeff
AU  - Sisler J
FAU - Turner, Donna
AU  - Turner D
FAU - Lobchuk, Michelle
AU  - Lobchuk M
FAU - McClement, Susan
AU  - McClement S
CN  - CIHR/CCMB Team in Primary Care Oncology (PCO-NET)
LA  - eng
SI  - ClinicalTrials.gov/NCT01026753
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20120517
PL  - England
TA  - BMC Cancer
JT  - BMC cancer
JID - 100967800
SB  - IM
MH  - *Access to Information
MH  - Aged
MH  - Colorectal Neoplasms/*blood/*diagnosis
MH  - Community Health Services/methods
MH  - Early Detection of Cancer/methods
MH  - Female
MH  - Health Services Accessibility
MH  - *Hotlines
MH  - Humans
MH  - Information Dissemination
MH  - *Internet
MH  - Male
MH  - Manitoba
MH  - Middle Aged
MH  - *Occult Blood
MH  - Patient Education as Topic
MH  - Physicians, Family
MH  - Primary Health Care
MH  - Randomized Controlled Trials as Topic/methods
PMC - PMC3495851
EDAT- 2012/05/23 06:00
MHDA- 2013/07/16 06:00
CRDT- 2012/05/22 06:00
PHST- 2012/03/22 00:00 [received]
PHST- 2012/04/30 00:00 [accepted]
PHST- 2012/05/22 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2013/07/16 06:00 [medline]
AID - 1471-2407-12-182 [pii]
AID - 10.1186/1471-2407-12-182 [doi]
PST - epublish
SO  - BMC Cancer. 2012 May 17;12:182. doi: 10.1186/1471-2407-12-182.


PMID- 22607386
OWN - NLM
STAT- MEDLINE
DCOM- 20130222
LR  - 20211021
IS  - 1471-2458 (Electronic)
IS  - 1471-2458 (Linking)
VI  - 12
DP  - 2012 May 20
TI  - Mental health care for irregular migrants in Europe: barriers and how they are
      overcome.
PG  - 367
LID - 10.1186/1471-2458-12-367 [doi]
AB  - BACKGROUND: Irregular migrants (IMs) are exposed to a wide range of risk factors 
      for developing mental health problems. However, little is known about whether and
      how they receive mental health care across European countries. The aims of this
      study were (1) to identify barriers to mental health care for IMs, and (2) to
      explore ways by which these barriers are overcome in practice. METHODS: Data from
      semi-structured interviews with 25 experts in the field of mental health care for
      IMs in the capital cities of 14 European countries were analysed using thematic
      analysis. RESULTS: Experts reported a range of barriers to mental health care for
      IMs. These include the absence of legal entitlements to health care in some
      countries or a lack of awareness of such entitlements, administrative obstacles, 
      a shortage of culturally sensitive care, the complexity of the social needs of
      IMs, and their fear of being reported and deported. These barriers can be partly 
      overcome by networks of committed professionals and supportive services. NGOs
      have become important initial points of contact for IMs, providing mental health 
      care themselves or referring IMs to other suitable services. However, these
      services are often confronted with the ethical dilemma of either acting according
      to the legislation and institutional rules or providing care for humanitarian
      reasons, which involves the risk of acting illegally and providing care without
      authorisation. CONCLUSIONS: Even in countries where access to health care is
      legally possible for IMs, various other barriers remain. Some of these are common
      to all migrants, whilst others are specific for IMs. Attempts at improving mental
      health care for IMs should consider barriers beyond legal entitlement, including 
      communicating information about entitlement to mental health care professionals
      and patients, providing culturally sensitive care and ensuring sufficient
      resources.
FAU - Strassmayr, Christa
AU  - Strassmayr C
AD  - Ludwig Boltzmann Institute for Social Psychiatry, Lazarettgasse 14A-912, 1090
      Vienna, Austria. christa.strassmayr@lubis.lbg.ac.at
FAU - Matanov, Aleksandra
AU  - Matanov A
FAU - Priebe, Stefan
AU  - Priebe S
FAU - Barros, Henrique
AU  - Barros H
FAU - Canavan, Reamonn
AU  - Canavan R
FAU - Diaz-Olalla, Jose Manuel
AU  - Diaz-Olalla JM
FAU - Gabor, Edina
AU  - Gabor E
FAU - Gaddini, Andrea
AU  - Gaddini A
FAU - Greacen, Tim
AU  - Greacen T
FAU - Holcnerova, Petra
AU  - Holcnerova P
FAU - Kluge, Ulrike
AU  - Kluge U
FAU - Welbel, Marta
AU  - Welbel M
FAU - Nicaise, Pablo
AU  - Nicaise P
FAU - Schene, Aart H
AU  - Schene AH
FAU - Soares, Joaquim J F
AU  - Soares JJ
FAU - Katschnig, Heinz
AU  - Katschnig H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120520
PL  - England
TA  - BMC Public Health
JT  - BMC public health
JID - 100968562
SB  - IM
MH  - Attitude of Health Personnel
MH  - Europe
MH  - *Health Services Accessibility/legislation & jurisprudence
MH  - Health Services Research
MH  - Humans
MH  - Mental Health Services/legislation & jurisprudence/*organization & administration
MH  - Qualitative Research
MH  - Transients and Migrants/legislation & jurisprudence/*psychology
PMC - PMC3528475
EDAT- 2012/05/23 06:00
MHDA- 2013/02/23 06:00
CRDT- 2012/05/22 06:00
PHST- 2011/11/15 00:00 [received]
PHST- 2012/04/19 00:00 [accepted]
PHST- 2012/05/22 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2013/02/23 06:00 [medline]
AID - 1471-2458-12-367 [pii]
AID - 10.1186/1471-2458-12-367 [doi]
PST - epublish
SO  - BMC Public Health. 2012 May 20;12:367. doi: 10.1186/1471-2458-12-367.


PMID- 22607302
OWN - NLM
STAT- MEDLINE
DCOM- 20121106
LR  - 20220408
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 13
DP  - 2012 May 18
TI  - Behavioral activation-based guided self-help treatment administered through a
      smartphone application: study protocol for a randomized controlled trial.
PG  - 62
LID - 10.1186/1745-6215-13-62 [doi]
AB  - BACKGROUND: The need for cost-effective interventions for people suffering from
      major depressive disorders is essential. Behavioral activation is an intervention
      that can largely benefit from the use of new mobile technologies (for example
      smartphones). Therefore, developing smartphone-based behavioral activation
      interventions might be a way to develop cost-effective treatments for people
      suffering from major depressive disorders. The aim of this study will be to test 
      the effects of a smartphone-delivered behavioral activation treatment. METHODS:
      The study will be a randomized controlled trial with a sample size of 120
      participants, with 60 patients in each group. The treatment group includes an
      8-week smartphone-based behavioral activation intervention, with minimal
      therapist contact. The smartphone-based intervention consists of a web-based
      psychoeducation, and a smartphone application. There is also a back-end system
      where the therapist can see reports from the patients or activities being
      reported. In the attention control group, we will include brief online education 
      and then recommend use of a smartphone application that is not directly aimed at 
      depression (for example, 'Effective meditation'). The duration of the control
      condition will also be 8 weeks. For ethical reasons we will give the participants
      in the control group access to the behavioral activation treatment following the 
      8-week treatment period. DISCUSSIONS: We believe that this trial has at least
      three important implications. First, we believe that smartphones can be
      integrated even further into society and therefore may serve an important role in
      health care. Second, while behavioral activation is a psychological treatment
      approach for which there is empirical support, the use of a smartphone
      application could serve as the therapist's prolonged arm into the daily life of
      the patient. Third, as we have been doing trials on guided Internet treatment for
      more than 10 years it is now time to move to the next generation of information
      technology - smartphones - which are not only relevant for Swedish conditions but
      also for developing countries in the world which are increasingly empowered by
      mobile phones with Internet connection. TRIAL REGISTRATION: ClinicalTrials.gov
      NCT01463020.
FAU - Ly, Kien Hoa
AU  - Ly KH
AD  - Department of Behavioral Sciences and Learning, Swedish Institute for Disability 
      Research, Linkoping University, Linkoping, Sweden. kien.hoa.ly@liu.se
FAU - Carlbring, Per
AU  - Carlbring P
FAU - Andersson, Gerhard
AU  - Andersson G
LA  - eng
SI  - ClinicalTrials.gov/NCT01463020
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20120518
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
SB  - IM
MH  - Behavior Therapy/*instrumentation/methods
MH  - *Cell Phone
MH  - Depressive Disorder, Major/diagnosis/psychology/*therapy
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Internet
MH  - Patient Education as Topic
MH  - Psychiatric Status Rating Scales
MH  - *Research Design
MH  - Self Care/*instrumentation
MH  - Sweden
MH  - Time Factors
MH  - Treatment Outcome
PMC - PMC3404948
EDAT- 2012/05/23 06:00
MHDA- 2012/11/07 06:00
CRDT- 2012/05/22 06:00
PHST- 2011/11/24 00:00 [received]
PHST- 2012/05/18 00:00 [accepted]
PHST- 2012/05/22 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2012/11/07 06:00 [medline]
AID - 1745-6215-13-62 [pii]
AID - 10.1186/1745-6215-13-62 [doi]
PST - epublish
SO  - Trials. 2012 May 18;13:62. doi: 10.1186/1745-6215-13-62.


PMID- 22607273
OWN - NLM
STAT- MEDLINE
DCOM- 20130129
LR  - 20120913
IS  - 1545-293X (Electronic)
IS  - 1527-8204 (Linking)
VI  - 13
DP  - 2012
TI  - Genetic discrimination: international perspectives.
PG  - 433-54
LID - 10.1146/annurev-genom-090711-163800 [doi]
AB  - Genetic discrimination (GD) is a complex, multifaceted ethical, psychosocial, and
      legal phenomenon. It is defined as the differential treatment of asymptomatic
      individuals or their relatives on the basis of their real or assumed genetic
      characteristics. This article presents an overview of GD within the contemporary 
      international context. It describes the concept of GD and its contextual
      features, reviews research evidence regarding people's experiences of GD and the 
      impact of GD within a range of domains, and provides an overview of legal and
      policy responses to GD that have emerged globally. We argue that GD is a
      significant and internationally established phenomenon that requires multilevel
      responses to ensure social justice and equitable outcomes for all citizens.
      Future research should monitor GD and its impacts within the community as well as
      institutions and should evaluate the effectiveness of legislative, policy,
      community education, and systemic responses.
FAU - Otlowski, M
AU  - Otlowski M
AD  - Faculty of Law, University of Tasmania, Hobart, Tasmania 7001, Australia.
      margaret.otlowski@utas.edu.au
FAU - Taylor, S
AU  - Taylor S
FAU - Bombard, Y
AU  - Bombard Y
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120515
PL  - United States
TA  - Annu Rev Genomics Hum Genet
JT  - Annual review of genomics and human genetics
JID - 100911346
SB  - IM
MH  - Employment/legislation & jurisprudence
MH  - Genetics, Medical/ethics/*legislation & jurisprudence
MH  - Humans
MH  - Insurance/ethics/legislation & jurisprudence
MH  - Internationality/legislation & jurisprudence
MH  - Public Policy
MH  - Social Discrimination/ethics/*legislation & jurisprudence/psychology
MH  - Social Justice
EDAT- 2012/05/23 06:00
MHDA- 2013/01/30 06:00
CRDT- 2012/05/22 06:00
PHST- 2012/05/22 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2013/01/30 06:00 [medline]
AID - 10.1146/annurev-genom-090711-163800 [doi]
PST - ppublish
SO  - Annu Rev Genomics Hum Genet. 2012;13:433-54. doi:
      10.1146/annurev-genom-090711-163800. Epub 2012 May 15.


PMID- 22607094
OWN - NLM
STAT- MEDLINE
DCOM- 20130605
LR  - 20121220
IS  - 1365-2648 (Electronic)
IS  - 0309-2402 (Linking)
VI  - 69
IP  - 1
DP  - 2013 Jan
TI  - Development and psychometric testing of a new tool for detecting moral distress: 
      the Moral Distress Thermometer.
PG  - 167-74
LID - 10.1111/j.1365-2648.2012.06036.x [doi]
AB  - AIM: To report the development and psychometric testing of the Moral Distress
      Thermometer. The Moral Distress Thermometer is a new screening tool to measure
      moral distress in nurses who practise in the hospital setting. BACKGROUND: Moral 
      distress occurs when one knows the ethically correct thing to do, but is
      prevented from acting on that perceived obligation. It is a well documented
      phenomenon with negative consequences that may be experienced by nurses. Creating
      an instrument to effectively and efficiently measure moral distress in a timely
      way has been identified as a priority for nursing. DESIGN: This study used a
      cross-sectional survey design. METHODS: Data collection for this research
      occurred in 2009. Participants simultaneously completed either the adult or
      pediatric version of the Moral Distress Scale version 2009 and the Moral Distress
      Thermometer. A total of 529 participants from various clinical areas completed
      both tools. RESULTS: Coefficients alpha were adequate for both Adult (0.90) and
      Pediatric (0.92) Moral Distress Scale 2009 scales. Statistically significant
      Pearson correlations were found for the Moral Distress Thermometer with Adult
      Moral Distress Scale 2009 and Pediatric Moral Distress Scale 2009 and higher
      Moral Distress Thermometer, Adult Moral Distress Scale 2009 and Pediatric Moral
      Distress Scale 2009 means for participants who had left or who considered leaving
      a position because of moral distress. CONCLUSION: These findings provide support 
      for the validity of the Moral Distress Thermometer.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Wocial, Lucia D
AU  - Wocial LD
AD  - Charles Warren Fairbanks Center for Medical Ethics, Indiana University Health,
      Indiana University School of Nursing, Indianapolis, Indiana, USA.
      lwocial@iuhealth.org
FAU - Weaver, Michael T
AU  - Weaver MT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120520
PL  - England
TA  - J Adv Nurs
JT  - Journal of advanced nursing
JID - 7609811
SB  - IM
MH  - Cross-Sectional Studies
MH  - Humans
MH  - *Morals
MH  - *Psychometrics
EDAT- 2012/05/23 06:00
MHDA- 2013/06/06 06:00
CRDT- 2012/05/22 06:00
PHST- 2012/05/22 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2013/06/06 06:00 [medline]
AID - 10.1111/j.1365-2648.2012.06036.x [doi]
PST - ppublish
SO  - J Adv Nurs. 2013 Jan;69(1):167-74. doi: 10.1111/j.1365-2648.2012.06036.x. Epub
      2012 May 20.


PMID- 22607038
OWN - NLM
STAT- MEDLINE
DCOM- 20130502
LR  - 20220409
IS  - 1365-2648 (Electronic)
IS  - 0309-2402 (Linking)
VI  - 68
IP  - 11
DP  - 2012 Nov
TI  - Nurses' competence in genetics: a mixed method systematic review.
PG  - 2387-98
LID - 10.1111/j.1365-2648.2012.06034.x [doi]
AB  - AIM: To ascertain the extent to which nurses are achieving the core competences
      in genetics appropriate for nursing practice. BACKGROUND: There is an increasing 
      focus on genetics in nursing, and relevant core competences have been developed. 
      However, it is unclear whether nurses are achieving these competences. DATA
      SOURCES: Four databases (CINAHL, Medline, The Allied and Complementary Medicine
      Database, and British Nursing Index) were searched. Hand searching of relevant
      reference lists and author names was also conducted. DESIGN: Systematic review.
      REVIEW METHODS: The systematic review was undertaken using methods described by
      the Centre for Reviews and Dissemination (University of York, 2008). Research
      studies published in English between January 2000-January 2011 reporting data
      focussing on nurse competence in genetics were eligible for inclusion. Data were 
      abstracted for inclusion in a table and subjected to thematic analysis: due to
      diversity of studies, a meta-analysis was not performed. RESULTS: Of 269 papers
      retrieved, 13 were eligible for inclusion. There were five main themes:
      knowledge, experience in using skills, ethical practice, perceived relevance, and
      confidence. Although the majority of participants believed genetics was relevant 
      to their role, their knowledge of genetic concepts was generally poor; however,
      most studies measured self-reported knowledge rather than assessing actual
      knowledge. CONCLUSIONS: There is little evidence on this topic, but it does
      appear from the available evidence that nurses are not demonstrating the
      competences needed to offer holistic health care to people with genetic
      conditions. Pre- and post-registration programmes must be enhanced to include
      genetic health care.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Skirton, Heather
AU  - Skirton H
AD  - Applied Health Genetics, School of Nursing & Midwifery, Faculty of Health,
      Education and Society, Plymouth University, Taunton, Somerset, UK.
      heather.skirton@plymouth.ac.uk
FAU - O'Connor, Anita
AU  - O'Connor A
FAU - Humphreys, Ann
AU  - Humphreys A
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20120520
PL  - England
TA  - J Adv Nurs
JT  - Journal of advanced nursing
JID - 7609811
SB  - IM
MH  - *Clinical Competence
MH  - Competency-Based Education
MH  - *Education, Nursing
MH  - Genetic Diseases, Inborn/*nursing/prevention & control
MH  - Genetics/*education
MH  - Holistic Nursing
MH  - Humans
MH  - Nurse's Role
EDAT- 2012/05/23 06:00
MHDA- 2013/05/03 06:00
CRDT- 2012/05/22 06:00
PHST- 2012/05/22 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2013/05/03 06:00 [medline]
AID - 10.1111/j.1365-2648.2012.06034.x [doi]
PST - ppublish
SO  - J Adv Nurs. 2012 Nov;68(11):2387-98. doi: 10.1111/j.1365-2648.2012.06034.x. Epub 
      2012 May 20.


PMID- 22607034
OWN - NLM
STAT- MEDLINE
DCOM- 20121001
LR  - 20211203
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 13
DP  - 2012 May 20
TI  - The decision-making process for the fate of frozen embryos by Japanese infertile 
      women: a qualitative study.
PG  - 9
LID - 10.1186/1472-6939-13-9 [doi]
AB  - BACKGROUND: Previous studies have found that the decision-making process for
      stored unused frozen embryos involves much emotional burden influenced by
      socio-cultural factors. This study aims to ascertain how Japanese patients make a
      decision on the fate of their frozen embryos: whether to continue storage discard
      or donate to research. METHODS: Ten Japanese women who continued storage, 5 who
      discarded and 16 who donated to research were recruited from our infertility
      clinic. Tape-recorded interviews were transcribed and analyzed for emergent
      themes. RESULTS: A model of patients' decision-making processes for the fate of
      frozen embryos was developed, with a common emergent theme, "coming to terms with
      infertility" resulting in either acceptance or postponing acceptance of their
      infertility. The model consisted of 5 steps: 1) the embryo-transfer moratorium
      was sustained, 2) the "Mottainai"- embryo and having another child were
      considered; 3) cost reasonability was taken into account; 4) partner's opinion
      was confirmed to finally decide whether to continue or discontinue storage. Those
      discontinuing, then contemplated 5): the effect of donation. Great emotional
      conflict was expressed in the theme, steps 2, 4, and 5. CONCLUSIONS: Patients' 5 
      step decision-making process for the fate of frozen embryos was profoundly
      affected by various Japanese cultural values and moral standards. At the end of
      their decision, patients used culturally inherent values and standards to come to
      terms with their infertility. While there is much philosophical discussion on the
      moral status of the embryo worldwide, this study, with actual views of patients
      who own them, will make a significant contribution to empirical ethics from the
      practical viewpoint.
FAU - Takahashi, Shizuko
AU  - Takahashi S
AD  - The Department of Obstetrics and Gynecology, The University of Tokyo School of
      Medicine, Tokyo, Japan. shizukoimai@hotmail.com
FAU - Fujita, Misao
AU  - Fujita M
FAU - Fujimoto, Akihisa
AU  - Fujimoto A
FAU - Fujiwara, Toshihiro
AU  - Fujiwara T
FAU - Yano, Tetsu
AU  - Yano T
FAU - Tsutsumi, Osamu
AU  - Tsutsumi O
FAU - Taketani, Yuji
AU  - Taketani Y
FAU - Akabayashi, Akira
AU  - Akabayashi A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120520
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Adult
MH  - *Asians/psychology/statistics & numerical data
MH  - Conflict, Psychological
MH  - *Cryopreservation/economics
MH  - *Cultural Characteristics
MH  - *Decision Making/ethics
MH  - *Embryo Disposition
MH  - *Embryo Research
MH  - Emotions
MH  - Female
MH  - Humans
MH  - *Infertility/psychology
MH  - Japan
MH  - Male
MH  - *Moral Obligations
MH  - Qualitative Research
MH  - *Sexual Partners
MH  - Surveys and Questionnaires
PMC - PMC3405475
EDAT- 2012/05/23 06:00
MHDA- 2012/10/02 06:00
CRDT- 2012/05/22 06:00
PHST- 2011/04/07 00:00 [received]
PHST- 2012/05/20 00:00 [accepted]
PHST- 2012/05/22 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2012/10/02 06:00 [medline]
AID - 1472-6939-13-9 [pii]
AID - 10.1186/1472-6939-13-9 [doi]
PST - epublish
SO  - BMC Med Ethics. 2012 May 20;13:9. doi: 10.1186/1472-6939-13-9.


PMID- 22606995
OWN - NLM
STAT- MEDLINE
DCOM- 20130218
LR  - 20211021
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 13
DP  - 2012 May 20
TI  - The four principles: can they be measured and do they predict ethical decision
      making?
PG  - 10
LID - 10.1186/1472-6939-13-10 [doi]
AB  - BACKGROUND: The four principles of Beauchamp and Childress--autonomy,
      non-maleficence, beneficence and justice--have been extremely influential in the 
      field of medical ethics, and are fundamental for understanding the current
      approach to ethical assessment in health care. This study tests whether these
      principles can be quantitatively measured on an individual level, and then
      subsequently if they are used in the decision making process when individuals are
      faced with ethical dilemmas. METHODS: The Analytic Hierarchy Process was used as 
      a tool for the measurement of the principles. Four scenarios, which involved
      conflicts between the medical ethical principles, were presented to participants 
      who then made judgments about the ethicality of the action in the scenario, and
      their intentions to act in the same manner if they were in the situation.
      RESULTS: Individual preferences for these medical ethical principles can be
      measured using the Analytic Hierarchy Process. This technique provides a useful
      tool in which to highlight individual medical ethical values. On average,
      individuals have a significant preference for non-maleficence over the other
      principles, however, and perhaps counter-intuitively, this preference does not
      seem to relate to applied ethical judgements in specific ethical dilemmas.
      CONCLUSIONS: People state they value these medical ethical principles but they do
      not actually seem to use them directly in the decision making process. The
      reasons for this are explained through the lack of a behavioural model to account
      for the relevant situational factors not captured by the principles. The
      limitations of the principles in predicting ethical decision making are
      discussed.
FAU - Page, Katie
AU  - Page K
AD  - School of Public Health, Institute of Health and Biomedical Innovation,
      Queensland University of Technology, Australia. katie.page@qut.edu.au
LA  - eng
PT  - Journal Article
DEP - 20120520
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Beneficence
MH  - Blood Transfusion/ethics
MH  - Confidentiality/ethics
MH  - Decision Making/*ethics
MH  - Female
MH  - Fertilization in Vitro/ethics
MH  - Humans
MH  - Intention
MH  - Judgment
MH  - Male
MH  - Middle Aged
MH  - Ownership/ethics
MH  - *Personal Autonomy
MH  - Religion and Medicine
MH  - *Social Justice/ethics
MH  - Suicide, Assisted/ethics
MH  - Surveys and Questionnaires
MH  - Young Adult
PMC - PMC3528420
EDAT- 2012/05/23 06:00
MHDA- 2013/02/19 06:00
CRDT- 2012/05/22 06:00
PHST- 2012/01/22 00:00 [received]
PHST- 2012/05/20 00:00 [accepted]
PHST- 2012/05/22 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2013/02/19 06:00 [medline]
AID - 1472-6939-13-10 [pii]
AID - 10.1186/1472-6939-13-10 [doi]
PST - epublish
SO  - BMC Med Ethics. 2012 May 20;13:10. doi: 10.1186/1472-6939-13-10.


PMID- 22606923
OWN - NLM
STAT- MEDLINE
DCOM- 20120619
LR  - 20191210
IS  - 1075-2994 (Print)
VI  - 21
IP  - 2
DP  - 2012 Winter
TI  - Can the FDA improve oversight of foreign clinical trials?: Closing the
      information gap and moving towards a globalized regulatory scheme.
PG  - 493-511, 4 p preceding i
AB  - Currently, pharmaceutical companies' utilization of foreign clinical trial data
      is a ubiquitous and indispensable aspect of gaining approval to market drugs in
      the United States. Cost benefits, a larger pool of ready volunteer subjects, and 
      greater efficiency in clinical testing are some of the reasons for conducting
      clinical trials overseas. Despite these advantages, lack of proper oversight may 
      have serious public health implications regarding the integrity of clinical
      research, ethical treatment of human subjects, and drug safety. Due to the
      expansive global nature of foreign clinical trials, there are concerns with the
      FDA's ability to monitor and regulate these trials. This article examines the
      FDA's oversight of foreign clinical trials and the agency's limitations
      regulating these trials. In addition to looking at steps the FDA is taking to
      address these limitations, the article examines other potential regulatory and
      cooperative actions that can be taken to effectively monitor foreign clinical
      trials and to ensure data integrity and patient safety.
FAU - Ourso, Andre
AU  - Ourso A
AD  - Florida Department of Health, Prosecution Services Unit, Medical Division, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Health Law
JT  - Annals of health law
JID - 9306639
MH  - Advertising/legislation & jurisprudence
MH  - Clinical Trials as Topic/*legislation & jurisprudence
MH  - Drug Industry
MH  - Humans
MH  - Internationality/*legislation & jurisprudence
MH  - United States
MH  - *United States Food and Drug Administration
EDAT- 2012/05/23 06:00
MHDA- 2012/06/20 06:00
CRDT- 2012/05/22 06:00
PHST- 2012/05/22 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2012/06/20 06:00 [medline]
PST - ppublish
SO  - Ann Health Law. 2012 Winter;21(2):493-511, 4 p preceding i.


PMID- 22606762
OWN - NLM
STAT- MEDLINE
DCOM- 20120619
LR  - 20211021
IS  - 1362-3699 (Print)
IS  - 1362-3699 (Linking)
VI  - 28
IP  - 1
DP  - 2012 Jan-Mar
TI  - Towards the responsible conduct of scientific research: is ethics education
      enough?
PG  - 73-84
AB  - Much of the discourse on 'beyond the laboratory door' biosecurity to date has
      focused on the need to raise awareness among the scientific community of the
      risks posed by the rapid advancement of biotechnology in recent decades. While
      education is undoubtedly important, a growing body of evidence suggests that
      ethics education does not necessarily translate into ethical behaviour. This
      trend has already been reported in clinical settings, where research has
      highlighted doctors' own reports of ethically dubious practices and challenges
      when confronted with moral dilemmas in their everyday work. The purpose of this
      paper is to critically evaluate the practical value of ethics education and show 
      why it is an essential, although insufficient, measure for promoting a culture of
      responsible conduct of research. We conclude by highlighting the importance of
      continuing professional development as a way of maintaining life scientists'
      engagement with biosecurity issues and supporting them in active roles in the
      effective implementation of the Biological and Toxin Weapons Convention (BWC).
FAU - Novossiolova, Tatyana
AU  - Novossiolova T
AD  - Bradford Disarmament Research Centre, University of Bradford, Bradford, UK.
FAU - Sture, Judi
AU  - Sture J
LA  - eng
GR  - Wellcome Trust/United Kingdom
GR  - 096700/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Med Confl Surviv
JT  - Medicine, conflict, and survival
JID - 9612305
SB  - IM
CIN - Med Confl Surviv. 2012 Jan-Mar;28(1):99-105. PMID: 22606764
MH  - *Biological Science Disciplines
MH  - Ethics, Research/*education
MH  - Humans
MH  - Social Responsibility
PMC - PMC3378933
MID - UKMS48773
OID - NLM: UKMS48773
EDAT- 2012/05/23 06:00
MHDA- 2012/06/20 06:00
CRDT- 2012/05/22 06:00
PHST- 2012/05/22 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2012/06/20 06:00 [medline]
AID - 10.1080/13623699.2012.658627 [doi]
PST - ppublish
SO  - Med Confl Surviv. 2012 Jan-Mar;28(1):73-84. doi: 10.1080/13623699.2012.658627.


PMID- 22606759
OWN - NLM
STAT- MEDLINE
DCOM- 20120619
LR  - 20120521
IS  - 1362-3699 (Print)
IS  - 1362-3699 (Linking)
VI  - 28
IP  - 1
DP  - 2012 Jan-Mar
TI  - Lessons learned from implementing education on dual-use in Austria, Italy,
      Pakistan and Sweden.
PG  - 31-44
AB  - This paper provides insights into the achievements and challenges of implementing
      education on dual-use in four countries: Austria, Italy, Pakistan and Sweden. It 
      draws attention to the different institutional mechanisms through which dual-use 
      education may be introduced into academic curricula and some of the difficulties 
      encountered in this process. It concludes that there is no 'one size fits all'
      approach to the implementation of dual-use education. Rather, initiatives must be
      tailored to suit the teaching traditions, geographical and historical context in 
      which they are being delivered. However, a number of common principles and themes
      can be derived from all four cases. All these courses bring together a number of 
      different topics that place 'dual-use' in the broader context of biosafety,
      biosecurity, ethics, law and the environment. The case studies suggest that
      success in this area depends largely on the leadership and commitment of
      individuals directly involved in teaching, who are active within the scientific
      community.
FAU - Revill, James
AU  - Revill J
AD  - SPRU (Science and Technology Policy Research), University of Sussex, UK.
      j.revill@sussex.ac.uk
FAU - Carnevali, M Daniela Candia
AU  - Carnevali MD
FAU - Forsberg, Ake
AU  - Forsberg A
FAU - Holmstrom, Anna
AU  - Holmstrom A
FAU - Rath, Johannes
AU  - Rath J
FAU - Shinwari, Zabta Khan
AU  - Shinwari ZK
FAU - Mancini, Giulio M
AU  - Mancini GM
LA  - eng
PT  - Journal Article
PL  - England
TA  - Med Confl Surviv
JT  - Medicine, conflict, and survival
JID - 9612305
SB  - IM
CIN - Med Confl Surviv. 2012 Jan-Mar;28(1):99-105. PMID: 22606764
MH  - Austria
MH  - Biological Science Disciplines/*education
MH  - Biological Warfare/prevention & control
MH  - Curriculum
MH  - Humans
MH  - *International Cooperation
MH  - Laboratory Personnel/education
MH  - Pakistan
MH  - Research Personnel/education
MH  - *Security Measures
MH  - Sweden
EDAT- 2012/05/23 06:00
MHDA- 2012/06/20 06:00
CRDT- 2012/05/22 06:00
PHST- 2012/05/22 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2012/06/20 06:00 [medline]
AID - 10.1080/13623699.2012.658624 [doi]
PST - ppublish
SO  - Med Confl Surviv. 2012 Jan-Mar;28(1):31-44. doi: 10.1080/13623699.2012.658624.


PMID- 22606758
OWN - NLM
STAT- MEDLINE
DCOM- 20120619
LR  - 20211021
IS  - 1362-3699 (Print)
IS  - 1362-3699 (Linking)
VI  - 28
IP  - 1
DP  - 2012 Jan-Mar
TI  - Research infrastructures, policies and the 'web of prevention': the ethical
      implications of inadequate research environments.
PG  - 19-30
AB  - The dual-use potential of scientific research refers to the possibility that any 
      beneficial scientific research may be misused for nefarious purposes by a third
      party. This potential within the life sciences has led to much discussion
      regarding ways to raise awareness and limit possible harm. The concept of a 'web 
      of prevention' as a multifaceted system for addressing this potential for harm
      provides a comprehensive method of conceptualizing a system of controls in the
      life sciences. The web of prevention involves multiple stakeholders, from diverse
      backgrounds such as science, public health, security studies and governance.
      Research within the life sciences relies on a number of different structures,
      such as waste disposal and border controls, which provide a comprehensive
      environment for scientists to work in. The web of prevention relies on the
      assumption of these systems working to support any further initiatives that are
      proposed. Unfortunately, in many countries around the world, these systems are
      insufficiently addressed, which may raise ethical problems. Structural problems
      may undermine the web of prevention and alter the responsibilities attributed to 
      the individual scientist within this system. Examples from sub-Saharan Africa
      illustrate two pertinent structural difficulties, and these are discussed in
      relation to ethical responsibilities.
FAU - Bezuidenhout, Louise
AU  - Bezuidenhout L
AD  - Department of Sociology and Philosophy, University of Exeter, Exeter, UK.
      Imb214@exeter.ac.uk
LA  - eng
GR  - 087351/Wellcome Trust/United Kingdom
PT  - Journal Article
PL  - England
TA  - Med Confl Surviv
JT  - Medicine, conflict, and survival
JID - 9612305
SB  - IM
CIN - Med Confl Surviv. 2012 Jan-Mar;28(1):99-105. PMID: 22606764
MH  - *Biological Science Disciplines
MH  - Biological Warfare/prevention & control
MH  - *Ethics, Research
MH  - Humans
MH  - *International Cooperation
MH  - Policy Making
MH  - Security Measures
MH  - Social Responsibility
PMC - PMC4724882
MID - EMS66137
OID - NLM: EMS66137
EDAT- 2012/05/23 06:00
MHDA- 2012/06/20 06:00
CRDT- 2012/05/22 06:00
PHST- 2012/05/22 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2012/06/20 06:00 [medline]
AID - 10.1080/13623699.2012.658623 [doi]
PST - ppublish
SO  - Med Confl Surviv. 2012 Jan-Mar;28(1):19-30. doi: 10.1080/13623699.2012.658623.


PMID- 22606757
OWN - NLM
STAT- MEDLINE
DCOM- 20120619
LR  - 20120521
IS  - 1362-3699 (Print)
IS  - 1362-3699 (Linking)
VI  - 28
IP  - 1
DP  - 2012 Jan-Mar
TI  - A life scientist, an engineer and a social scientist walk into a lab: challenges 
      of dual-use engagement and education in synthetic biology.
PG  - 5-18
AB  - The discussion of dual-use education is often predicated on a discrete population
      of practicing life scientists exhibiting certain deficiencies in awareness or
      expertise. This has lead to the claim that there is a greater requirement for
      awareness raising and education amongst this population. However, there is yet to
      be an inquiry into the impact of the 'convergent' nature of emerging
      techno-sciences upon the prospects of dual-use education. The field of synthetic 
      biology, although often portrayed as homogeneous, is in fact composed of various 
      sub-fields and communities. Its practitioners have diverse academic backgrounds. 
      The research institutions that have fostered its development in the UK often have
      their own sets of norms and practices in engagement with ethical, legal and
      social issues associated with scientific knowledge and technologies. The area is 
      also complicated by the emergence of synthetic biologists outside traditional
      research environments, the so called 'do-it-yourself' or 'garage biologists'.
      This paper untangles some of the complexities in the current state of synthetic
      biology and addresses the prospects for dual-use education for practitioners. It 
      provides a short overview of the field and discusses identified dual-use issues. 
      There follows a discussion of UK networks in synthetic biology, including their
      engagement with ethical, legal, social and dual-use issues and limited
      educational efforts in relation to these. It concludes by outlining options for
      developing a more systematic dual-use education strategy for synthetic biology.
FAU - Edwards, Brett
AU  - Edwards B
AD  - PoLIS, University of Bath, Bath, UK.
FAU - Kelle, Alexander
AU  - Kelle A
LA  - eng
PT  - Journal Article
PL  - England
TA  - Med Confl Surviv
JT  - Medicine, conflict, and survival
JID - 9612305
SB  - IM
CIN - Med Confl Surviv. 2012 Jan-Mar;28(1):99-105. PMID: 22606764
MH  - Ethics, Research
MH  - Humans
MH  - Security Measures
MH  - Social Responsibility
MH  - Synthetic Biology/*education
EDAT- 2012/05/23 06:00
MHDA- 2012/06/20 06:00
CRDT- 2012/05/22 06:00
PHST- 2012/05/22 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2012/06/20 06:00 [medline]
AID - 10.1080/13623699.2012.658659 [doi]
PST - ppublish
SO  - Med Confl Surviv. 2012 Jan-Mar;28(1):5-18. doi: 10.1080/13623699.2012.658659.


PMID- 22605702
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20211021
IS  - 1757-790X (Electronic)
IS  - 1757-790X (Linking)
VI  - 2012
DP  - 2012 Mar 20
TI  - Ethical indications for radiological procedures: a clearer picture.
LID - 10.1136/bcr.10.2011.5056 [doi]
LID - bcr1020115056 [pii]
AB  - An 80-year-old gentleman presented with long-standing diarrhoea and weight loss. 
      A large bowel malignancy was suspected but his co morbidity precluded major
      abdominal surgery. At the time of treatment CT colonography was not in common use
      and the investigation of choice was barium enema. Due to the invasive nature of
      this procedure the medical team decided it would not be in his best interests to 
      subject him to further investigation. Uncertainty surrounding his diagnosis was
      distressing for him and his family who felt that a firm diagnosis would allow
      them to plan his ongoing care needs. The patient accepted the risks and underwent
      a barium enema that confirmed the presence of a large bowel carcinoma that was
      inoperable. The case highlights how application of the ethical principles can aid
      the decision making process in difficult scenarios and emphasises the importance 
      of treating the individual and not the disease.
FAU - Clement, Rhys Gareth Ellis
AU  - Clement RG
AD  - Trauma and Orthopaedics Department, NHS Lothian, Edinburgh, UK.
      rhysclement@googlemail.com
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20120320
PL  - England
TA  - BMJ Case Rep
JT  - BMJ case reports
JID - 101526291
RN  - 0 (Contrast Media)
RN  - 25BB7EKE2E (Barium Sulfate)
SB  - IM
MH  - Aged, 80 and over
MH  - Barium Sulfate
MH  - Contrast Media
MH  - *Decision Making
MH  - Diagnosis, Differential
MH  - Enema
MH  - *Ethics, Medical
MH  - Humans
MH  - Intestinal Neoplasms/*diagnosis
MH  - Male
PMC - PMC3316837
EDAT- 2012/05/19 06:00
MHDA- 2013/02/13 06:00
CRDT- 2012/05/19 06:00
PHST- 2012/05/19 06:00 [entrez]
PHST- 2012/05/19 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
AID - bcr.10.2011.5056 [pii]
AID - 10.1136/bcr.10.2011.5056 [doi]
PST - epublish
SO  - BMJ Case Rep. 2012 Mar 20;2012. pii: bcr.10.2011.5056. doi:
      10.1136/bcr.10.2011.5056.


PMID- 22599361
OWN - NLM
STAT- MEDLINE
DCOM- 20130730
LR  - 20191210
IS  - 1399-3003 (Electronic)
IS  - 0903-1936 (Linking)
VI  - 41
IP  - 2
DP  - 2013 Feb
TI  - European COPD Audit: design, organisation of work and methodology.
PG  - 270-6
LID - 10.1183/09031936.00021812 [doi]
AB  - Clinical audit has an important role as an indicator of the clinical practice in 
      a given community. The European Respiratory Society (ERS) chronic obstructive
      pulmonary disease (COPD) audit was designed as a pilot study to evaluate clinical
      practice variability as well as clinical and organisational factors related to
      outcomes for COPD hospital admissions across Europe. The study was designed as a 
      prospective observational noninterventional cohort trial, in which 422 hospitals 
      from 13 European countries participated. There were two databases: one for
      hospital's resources and organisation and one for clinical information. The study
      was comprised of an initial 8-week phase during which all consecutive cases
      admitted to hospital due to an exacerbation of COPD were identified and
      information on clinical practice was gathered. During the 90-day second phase,
      mortality and readmissions were recorded. Patient data were anonymised and
      encrypted through a multi-lingual web-tool. As there is no pan-European Ethics
      Committee for audits, all partners accepted the general ethical rules of the ERS 
      and ensured compliance with their own national ethical requirements. This paper
      describes the methodological issues encountered in organising and delivering a
      multi-national European audit, highlighting goals, barriers and achievements, and
      provides valuable information for those interested in developing clinical audits.
FAU - Lopez-Campos, Jose Luis
AU  - Lopez-Campos JL
AD  - Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del
      Rocio, Avda. Manuel Siurot s/n, Seville, Spain. lcampos@separ.es
FAU - Hartl, Sylvia
AU  - Hartl S
FAU - Pozo-Rodriguez, Francisco
AU  - Pozo-Rodriguez F
FAU - Roberts, C Michael
AU  - Roberts CM
CN  - European COPD Audit team
LA  - eng
PT  - Journal Article
DEP - 20120517
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
SB  - IM
MH  - *Clinical Audit
MH  - Europe
MH  - Humans
MH  - Models, Organizational
MH  - Outcome Assessment, Health Care
MH  - Patient Admission
MH  - Pilot Projects
MH  - Practice Patterns, Physicians'
MH  - Prospective Studies
MH  - Pulmonary Disease, Chronic Obstructive/*therapy
MH  - Pulmonary Medicine/methods/*standards
MH  - Reproducibility of Results
MH  - Treatment Outcome
IR  - Roberts CM
FIR - Roberts, C M
IR  - Hartl S
FIR - Hartl, S
IR  - Lopez-Campos JL
FIR - Lopez-Campos, J L
IR  - Pozo-Rodriguez F
FIR - Pozo-Rodriguez, F
IR  - Lopez-Campos JL
FIR - Lopez-Campos, J L
IR  - Castro-Acosta A
FIR - Castro-Acosta, A
IR  - Abraira-Santos V
FIR - Abraira-Santos, V
IR  - Lopez-Quilez A
FIR - Lopez-Quilez, A
IR  - Dorado J
FIR - Dorado, J
IR  - Burghuber O
FIR - Burghuber, O
IR  - Kohansal R
FIR - Kohansal, R
IR  - Janssens W
FIR - Janssens, W
IR  - Heinen V
FIR - Heinen, V
IR  - Miculinic N
FIR - Miculinic, N
IR  - Puretic H
FIR - Puretic, H
IR  - Tzanakis N
FIR - Tzanakis, N
IR  - Nontas Kosmas E
FIR - Nontas Kosmas, E
IR  - McCormack S
FIR - McCormack, S
IR  - McDonell T
FIR - McDonell, T
IR  - Farrugia Jones C
FIR - Farrugia Jones, C
IR  - Chorostowska-Wynimko J
FIR - Chorostowska-Wynimko, J
IR  - Mihaltan F
FIR - Mihaltan, F
IR  - Munteanu I
FIR - Munteanu, I
IR  - Alexandru Bogdan M
FIR - Alexandru Bogdan, M
IR  - Solovic I
FIR - Solovic, I
IR  - Tkacova R
FIR - Tkacova, R
IR  - Pozo-Rodriguez F
FIR - Pozo-Rodriguez, F
IR  - Ancochea J
FIR - Ancochea, J
IR  - Stolz D
FIR - Stolz, D
IR  - Polatli M
FIR - Polatli, M
IR  - Sen E
FIR - Sen, E
IR  - Bucknall C
FIR - Bucknall, C
IR  - Welham S
FIR - Welham, S
IR  - Routh C
FIR - Routh, C
IR  - Haan M
FIR - Haan, M
IR  - Zarelli M
FIR - Zarelli, M
IR  - Lechat E
FIR - Lechat, E
IR  - Buckingham RJ
FIR - Buckingham, R J
IR  - Joos G
FIR - Joos, G
EDAT- 2012/05/19 06:00
MHDA- 2013/07/31 06:00
CRDT- 2012/05/19 06:00
PHST- 2012/05/19 06:00 [entrez]
PHST- 2012/05/19 06:00 [pubmed]
PHST- 2013/07/31 06:00 [medline]
AID - 09031936.00021812 [pii]
AID - 10.1183/09031936.00021812 [doi]
PST - ppublish
SO  - Eur Respir J. 2013 Feb;41(2):270-6. doi: 10.1183/09031936.00021812. Epub 2012 May
      17.


PMID- 22596265
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20181201
IS  - 1538-3660 (Electronic)
IS  - 1521-2491 (Linking)
VI  - 14
IP  - 3
DP  - 2012 May-Jun
TI  - Ethical conduct of humanitarian medical missions: I. Informed Consent.
PG  - 215-7
LID - 10.1001/archfacial.2011.1643 [doi]
AB  - Altruistic and socially conscious physicians are dedicating a portion of their
      professional lives to humanitarian relief of disadvantaged populations in
      increasing numbers. These efforts are primarily carried out through short-term
      medical missions(STMMs) throughout the international community.(1) There is a
      great deal of professional and personal reward to physicians who participate in
      medical missions, and their experiences as related to colleagues may serve to
      encourage others to participate as well. Indeed, there is an increasing interest 
      in, and enthusiasm for, medical students to participate in international
      volunteer electives during medical school, particularly in developing countries. 
      Their positive experiences often shape their future commitment to volunteerism as
      a physician.(2)
FAU - Holt, G Richard
AU  - Holt GR
AD  - Department of Otolaryngology-Head and Neck Surgery, The University of Texas
      Health Science Center, San Antonio, USA. holtg@uthscsa.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Arch Facial Plast Surg
JT  - Archives of facial plastic surgery
JID - 100883500
SB  - IM
MH  - Cultural Competency
MH  - Developing Countries
MH  - Humans
MH  - Informed Consent/ethics
MH  - Medical Missions/*ethics
MH  - Standard of Care/ethics
MH  - United States
MH  - Volunteers
EDAT- 2012/05/19 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/05/19 06:00
PHST- 2012/05/19 06:00 [entrez]
PHST- 2012/05/19 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 1157668 [pii]
AID - 10.1001/archfacial.2011.1643 [doi]
PST - ppublish
SO  - Arch Facial Plast Surg. 2012 May-Jun;14(3):215-7. doi:
      10.1001/archfacial.2011.1643.


PMID- 22595864
OWN - NLM
STAT- MEDLINE
DCOM- 20140716
LR  - 20130820
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 9
DP  - 2013 Sep
TI  - Withdrawing and withholding artificial nutrition and hydration from patients in a
      minimally conscious state: re: M and its repercussions.
PG  - 543-6
LID - 10.1136/medethics-2012-100662 [doi]
AB  - In 2011 the English Court of Protection ruled that it would be unlawful to
      withdraw artificial nutrition and hydration from a woman, M, who had been in a
      minimally conscious state for 8 years. It was reported as the first English legal
      case concerning withdrawal of artificial nutrition and hydration from a patient
      in a minimally conscious state who was otherwise stable. In the absence of a
      valid and applicable advance decision refusing treatment, of other life-limiting 
      pathology or excessively burdensome suffering, the judgement makes it clear that 
      the obligation on health professionals falls strongly in favour of preserving
      life. Although the Court sought to limit the judgement as closely as possible to 
      the facts of the case, it is likely to have a significant impact on
      life-sustaining treatment decisions for people in states of low awareness. This
      paper outlines the main legal features of the judgement.
FAU - Sheather, Julian C
AU  - Sheather JC
AD  - Ethics Department, British MedicalAssociation, London WC1H 9JP, UK.
      jsheather@bma.org.uk
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20120517
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Adult
MH  - Advance Directives
MH  - Family/psychology
MH  - Female
MH  - Humans
MH  - Nutritional Support/*ethics
MH  - *Persistent Vegetative State/therapy
MH  - Personhood
MH  - Withholding Treatment/ethics/*legislation & jurisprudence
OTO - NOTNLM
OT  - Medical ethics
OT  - decision-making capacity
OT  - mental capacity
OT  - mental health
OT  - mental health legislation
EDAT- 2012/05/19 06:00
MHDA- 2014/07/17 06:00
CRDT- 2012/05/19 06:00
PHST- 2012/05/19 06:00 [entrez]
PHST- 2012/05/19 06:00 [pubmed]
PHST- 2014/07/17 06:00 [medline]
AID - medethics-2012-100662 [pii]
AID - 10.1136/medethics-2012-100662 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Sep;39(9):543-6. doi: 10.1136/medethics-2012-100662. Epub 2012
      May 17.


PMID- 22595863
OWN - NLM
STAT- MEDLINE
DCOM- 20140716
LR  - 20130820
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 9
DP  - 2013 Sep
TI  - Should we respect precedent autonomy in life-sustaining treatment decisions?
PG  - 547-50
LID - 10.1136/medethics-2012-100663 [doi]
AB  - The recent judgement in the case of Re:M in which the Court held that it would be
      unlawful to withdraw artificial nutrition and hydration from a woman in a
      minimally conscious state raises a number of ethical issues of wide application. 
      Central to these is the extent to which precedent autonomous decisions should be 
      respected in the absence of a legally binding advance decision. Well-being
      interests can survive the loss of many of the psychological faculties that
      support personhood. A decision to respect precedent autonomy can contradict the
      well-being interests of the individual after capacity is lost. These decisions
      raise difficult questions about personal identity and about the threshold of
      evidence that is required of an earlier decision in order for it to be respected.
FAU - Sheather, Julian C
AU  - Sheather JC
AD  - Ethics Department, British Medical Association, London WC1H 9JP, UK.
      jsheather@bma.org.uk
LA  - eng
PT  - Journal Article
DEP - 20120517
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Adult
MH  - Advance Directives/*legislation & jurisprudence
MH  - Ethics, Medical
MH  - Female
MH  - Humans
MH  - Life Support Systems/*ethics
MH  - Mental Competency/legislation & jurisprudence
MH  - *Persistent Vegetative State
MH  - *Personal Autonomy
MH  - Personhood
OTO - NOTNLM
OT  - Medical ethics
OT  - decision-making capacity
OT  - mental capacity
OT  - mental health
OT  - mental health legislation
EDAT- 2012/05/19 06:00
MHDA- 2014/07/17 06:00
CRDT- 2012/05/19 06:00
PHST- 2012/05/19 06:00 [entrez]
PHST- 2012/05/19 06:00 [pubmed]
PHST- 2014/07/17 06:00 [medline]
AID - medethics-2012-100663 [pii]
AID - 10.1136/medethics-2012-100663 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Sep;39(9):547-50. doi: 10.1136/medethics-2012-100663. Epub
      2012 May 17.


PMID- 22595822
OWN - NLM
STAT- MEDLINE
DCOM- 20130402
LR  - 20121022
IS  - 1532-1932 (Electronic)
IS  - 1521-6934 (Linking)
VI  - 26
IP  - 6
DP  - 2012 Dec
TI  - Ethical issues in infertility treatment.
PG  - 853-63
LID - 10.1016/j.bpobgyn.2012.04.002 [doi]
LID - S1521-6934(12)00070-3 [pii]
AB  - Two currently contentious domains in infertility treatment are discussed:
      assisted reproduction for same-sex couples and fertility preservation for women
      with cancer. Despite an increasing recognition of the rights of same-sex couples,
      in many countries they are still not eligible for assisted reproductive
      technology. The main justification for excluding same-sex couples from treatment 
      is that the welfare of the future children would be compromised. Empirical
      evidence, however, shows that this is not the case. Another group of
      non-infertile women seeking assistance from reproductive medicine are women with 
      cancer who are at risk of impaired or lost fertility as a result of their illness
      or cancer treatment. In this field, the future holds many promising options.
      Several of these, however, are currently in an experimental phase, which elicits 
      ethical concerns about participant recruitment and research participation of
      children.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Pennings, Guido
AU  - Pennings G
AD  - Bioethics Institute Ghent, Ghent University, Blandijnberg 2, Gent 9000, Belgium. 
      Guido.Pennings@UGent.be
FAU - Mertes, Heidi
AU  - Mertes H
LA  - eng
PT  - Journal Article
DEP - 20120516
PL  - Netherlands
TA  - Best Pract Res Clin Obstet Gynaecol
JT  - Best practice & research. Clinical obstetrics & gynaecology
JID - 101121582
SB  - IM
MH  - Child
MH  - Child Welfare
MH  - Female
MH  - Fertility Preservation/*ethics
MH  - *Homosexuality
MH  - Human Rights
MH  - Humans
MH  - Male
MH  - *Neoplasms
MH  - Reproductive Techniques, Assisted/*ethics
EDAT- 2012/05/19 06:00
MHDA- 2013/04/03 06:00
CRDT- 2012/05/19 06:00
PHST- 2012/02/25 00:00 [received]
PHST- 2012/04/23 00:00 [accepted]
PHST- 2012/05/19 06:00 [entrez]
PHST- 2012/05/19 06:00 [pubmed]
PHST- 2013/04/03 06:00 [medline]
AID - S1521-6934(12)00070-3 [pii]
AID - 10.1016/j.bpobgyn.2012.04.002 [doi]
PST - ppublish
SO  - Best Pract Res Clin Obstet Gynaecol. 2012 Dec;26(6):853-63. doi:
      10.1016/j.bpobgyn.2012.04.002. Epub 2012 May 16.


PMID- 22595589
OWN - NLM
STAT- MEDLINE
DCOM- 20120924
LR  - 20120518
IS  - 1531-5037 (Electronic)
IS  - 0022-3468 (Linking)
VI  - 47
IP  - 5
DP  - 2012 May
TI  - Feasibility of conducting a prospective cohort study in pediatric surgery:
      introducing the Caregiver Quality of Life of pediatric patients referred for
      feeding tube insertion (CARE) study.
PG  - 999-1004
LID - 10.1016/j.jpedsurg.2012.01.058 [doi]
AB  - INTRODUCTION: High-quality prospective cohort studies are needed to answer
      research questions focused on prognosis. To determine the feasibility of
      conducting this type of research, a prospective cohort study focused on
      investigating health-related quality of life (HRQoL) of caregivers of children
      who require a gastrostomy (G) tube at the McMaster Children's Hospital was
      piloted from November 2009 to May 2011. METHODS: Recruitment began after research
      ethics board approval. Feasibility data were collected on all caregivers of
      patients assessed for G tube placement by a pediatric surgeon including
      recruitment status, protocol compliance, and HRQoL. Data were collected at 1
      month and 2 weeks before surgery and 2 weeks and 3, 6, 9, and 12 months after
      surgery. Health-related quality of life measures included the Short Form 36v2,
      the Caregiver Strain Index, and the Parent Experience of Childhood Illness.
      RESULTS: A total of 117 G procedures were conducted, and 39 caregivers met
      eligibility criteria. Thirty-one caregivers were enrolled (79.5% recruitment
      rate), 8 parents were not interested, and 26 were missed. Protocol adherence to
      the follow-up schedule is high (91.3%). CONCLUSION: Conducting high-level
      research with long-term follow-up in pediatric surgery is challenging. Factors
      including low prevalence of patients and competing priorities for busy clinicians
      indicate that multicenter collaboration is essential to research success in this 
      field.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Pemberton, Julia
AU  - Pemberton J
AD  - Department of Surgery, McMaster Pediatric Surgery Research Collaborative,
      McMaster University, Hamilton, Ontario, Canada.
FAU - Nederveen, Josh
AU  - Nederveen J
FAU - Lamond, Ashley
AU  - Lamond A
FAU - Bailey, Karen
AU  - Bailey K
FAU - Ratcliffe, Elyanne
AU  - Ratcliffe E
FAU - Walton, J Mark
AU  - Walton JM
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - J Pediatr Surg
JT  - Journal of pediatric surgery
JID - 0052631
SB  - IM
MH  - Caregivers/*psychology
MH  - Child
MH  - Cohort Studies
MH  - Enteral Nutrition/*psychology
MH  - Feasibility Studies
MH  - Gastrostomy/*psychology
MH  - General Surgery
MH  - Humans
MH  - Parents/*psychology
MH  - Patient Compliance/*statistics & numerical data
MH  - *Patient Selection
MH  - Pediatrics
MH  - Pilot Projects
MH  - Prospective Studies
MH  - Psychological Tests
MH  - *Quality of Life
EDAT- 2012/05/19 06:00
MHDA- 2012/09/25 06:00
CRDT- 2012/05/19 06:00
PHST- 2012/01/23 00:00 [received]
PHST- 2012/01/26 00:00 [accepted]
PHST- 2012/05/19 06:00 [entrez]
PHST- 2012/05/19 06:00 [pubmed]
PHST- 2012/09/25 06:00 [medline]
AID - S0022-3468(12)00127-3 [pii]
AID - 10.1016/j.jpedsurg.2012.01.058 [doi]
PST - ppublish
SO  - J Pediatr Surg. 2012 May;47(5):999-1004. doi: 10.1016/j.jpedsurg.2012.01.058.


PMID- 22595041
OWN - NLM
STAT- MEDLINE
DCOM- 20130107
LR  - 20211021
IS  - 1472-6939 (Electronic)
IS  - 1472-6939 (Linking)
VI  - 13
DP  - 2012 May 17
TI  - Ethics, patient rights and staff attitudes in Shanghai's psychiatric hospitals.
PG  - 8
LID - 10.1186/1472-6939-13-8 [doi]
AB  - BACKGROUND: Adherence to ethical principles in clinical research and practice is 
      becoming topical issue in China, where the prevalence of mental illness is
      rising, but treatment facilities remain underdeveloped. This paper reports on a
      study aiming to understand the ethical knowledge and attitudes of Chinese mental 
      health professionals in relation to the process of diagnosis and treatment,
      informed consent, and privacy protection in clinical trials. METHODS: A
      self-administered survey was completed by 1110 medical staff recruited from
      Shanghai's 22 psychiatric hospitals. Simple random selection methods were used to
      identify target individuals from the computerized registry of staff. RESULTS: The
      final sample for analysis consisted 1094 medical staff (including 523 doctors,
      542 nurses, 8 pharmacologists and 21 other staff). The majority reported that
      their medical institutions had not established an Ethics Committee (87.8%) and
      agreed that Ethics Committees should be set up in their institutions (72.9%).
      Approximately half (52%) had not received systematic education in ethics, and
      almost all (89.1%) of the staff thought it was necessary. Nearly all participants
      (90.0%) knew the Shanghai Mental Health Regulations which was the first local
      regulations relating to mental health in China, but only 11% and 16.6%
      respectively knew of the Nuremberg Code and the Declaration of Helsinki. About
      half (51.8%) thought that the guardian should make the decision as to whether the
      patient participated in clinical trials or not. CONCLUSIONS: The study indicates 
      that most psychiatric hospitals in Shanghai have no Medical Ethics Committee.
      More than half the medical staff had not received systematic education and
      training in medical ethics and they have insufficient knowledge of the ethical
      issues related to clinical practice and trials. Training in ethics is recommended
      for medical staff during their training and as ongoing professional development.
FAU - Su, Liang
AU  - Su L
AD  - Department of Psychiatry, Huashan Hospital, Fudan University, School of Medicine,
      No. 12 Wulumuqi Road (middle), Shanghai 200040, People's Republic of China.
FAU - Huang, Jingjing
AU  - Huang J
FAU - Yang, Weimin
AU  - Yang W
FAU - Li, Huafang
AU  - Li H
FAU - Shen, Yifeng
AU  - Shen Y
FAU - Xu, Yifeng
AU  - Xu Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120517
PL  - England
TA  - BMC Med Ethics
JT  - BMC medical ethics
JID - 101088680
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Attitude of Health Personnel
MH  - China/epidemiology
MH  - *Ethics Committees, Research
MH  - *Ethics, Clinical/education
MH  - Female
MH  - Health Care Surveys
MH  - *Hospitals, Psychiatric/ethics/standards/statistics & numerical data/trends
MH  - Humans
MH  - *Informed Consent/ethics
MH  - Male
MH  - Mental Disorders/epidemiology
MH  - Middle Aged
MH  - Nurses/statistics & numerical data
MH  - Patient Rights
MH  - Pharmacists/statistics & numerical data
MH  - Physicians/statistics & numerical data
MH  - Surveys and Questionnaires
PMC - PMC3467163
EDAT- 2012/05/19 06:00
MHDA- 2013/01/08 06:00
CRDT- 2012/05/19 06:00
PHST- 2011/10/01 00:00 [received]
PHST- 2012/04/29 00:00 [accepted]
PHST- 2012/05/19 06:00 [entrez]
PHST- 2012/05/19 06:00 [pubmed]
PHST- 2013/01/08 06:00 [medline]
AID - 1472-6939-13-8 [pii]
AID - 10.1186/1472-6939-13-8 [doi]
PST - epublish
SO  - BMC Med Ethics. 2012 May 17;13:8. doi: 10.1186/1472-6939-13-8.


PMID- 22594970
OWN - NLM
STAT- MEDLINE
DCOM- 20120917
LR  - 20220309
IS  - 1878-5905 (Electronic)
IS  - 0142-9612 (Linking)
VI  - 33
IP  - 23
DP  - 2012 Aug
TI  - Combining adult stem cells and polymeric devices for tissue engineering in
      infarcted myocardium.
PG  - 5683-95
LID - 10.1016/j.biomaterials.2012.04.028 [doi]
AB  - An increasing number of studies in cardiac cell therapy have provided encouraging
      results for cardiac repair. Adult stem cells may overcome ethical and
      availability concerns, with the additional advantages, in some cases, to allow
      autologous grafts to be performed. However, the major problems of cell survival, 
      cell fate determination and engraftment after transplantation, still remain.
      Tissue-engineering strategies combining scaffolds and cells have been developed
      and have to be adapted for each type of application to enhance stem cell
      function. Scaffold properties required for cardiac cell therapy are here
      discussed. New tissue engineering advances that may be implemented in combination
      with adult stem cells for myocardial infarction therapy are also presented.
      Biomaterials not only provide a 3D support for the cells but may also mimic the
      structural architecture of the heart. Using hydrogels or particulate systems, the
      biophysical and biochemical microenvironments of transplanted cells can also be
      controlled. Advances in biomaterial engineering have permitted the development of
      sophisticated drug-releasing materials with a biomimetic 3D support that allow a 
      better control of the microenvironment of transplanted cells.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Karam, Jean-Pierre
AU  - Karam JP
AD  - LUNAM University, UMR S-1066, F-49933 Angers, France.
FAU - Muscari, Claudio
AU  - Muscari C
FAU - Montero-Menei, Claudia N
AU  - Montero-Menei CN
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120515
PL  - Netherlands
TA  - Biomaterials
JT  - Biomaterials
JID - 8100316
RN  - 0 (Drug Carriers)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
SB  - IM
MH  - Adult Stem Cells/*cytology/transplantation
MH  - Animals
MH  - Drug Carriers/chemistry
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins/administration & dosage
MH  - Myocardial Infarction/surgery/*therapy
MH  - Myocardium/*cytology
MH  - Tissue Engineering/*methods
MH  - Tissue Scaffolds/chemistry
EDAT- 2012/05/19 06:00
MHDA- 2012/09/18 06:00
CRDT- 2012/05/19 06:00
PHST- 2012/02/11 00:00 [received]
PHST- 2012/04/08 00:00 [accepted]
PHST- 2012/05/19 06:00 [entrez]
PHST- 2012/05/19 06:00 [pubmed]
PHST- 2012/09/18 06:00 [medline]
AID - S0142-9612(12)00450-4 [pii]
AID - 10.1016/j.biomaterials.2012.04.028 [doi]
PST - ppublish
SO  - Biomaterials. 2012 Aug;33(23):5683-95. doi: 10.1016/j.biomaterials.2012.04.028.
      Epub 2012 May 15.


PMID- 22594930
OWN - NLM
STAT- MEDLINE
DCOM- 20120918
LR  - 20120518
IS  - 1399-3038 (Electronic)
IS  - 0905-6157 (Linking)
VI  - 23
IP  - 4
DP  - 2012 Jun
TI  - Perspectives on allergen-specific immunotherapy in childhood: an EAACI position
      statement.
PG  - 300-6
LID - 10.1111/j.1399-3038.2012.01313.x [doi]
AB  - This article is the result of consensus reached by a working group of clinical
      experts in paediatric allergology as well as representatives from an ethical
      committee and the European Medicine Agency (EMA). The manuscript covers clinical,
      scientific, regulatory and ethical perspectives on allergen-specific
      immunotherapy in childhood. Unmet needs are identified. To fill the gaps and to
      bridge the different points of view, recommendations are made to researchers, to 
      scientific and patient organizations and to regulators and ethical committees.
      Working together for the benefit of the community is essential. The European
      Academy of Allergy and Clinical Immunology (EAACI) serves as the platform of such
      cooperation.
CI  - (c) 2012 John Wiley & Sons A/S.
FAU - Calderon, M A
AU  - Calderon MA
AD  - Department of Allergy and Respiratory Medicine, Royal Brompton Hospital, Imperial
      College, London, UK. m.calderon@imperial.ac.uk
FAU - Gerth van Wijk, R
AU  - Gerth van Wijk R
FAU - Eichler, I
AU  - Eichler I
FAU - Matricardi, P M
AU  - Matricardi PM
FAU - Varga, E M
AU  - Varga EM
FAU - Kopp, M V
AU  - Kopp MV
FAU - Eng, P
AU  - Eng P
FAU - Niggemann, B
AU  - Niggemann B
FAU - Nieto, A
AU  - Nieto A
FAU - Valovirta, E
AU  - Valovirta E
FAU - Eigenmann, P A
AU  - Eigenmann PA
FAU - Pajno, G
AU  - Pajno G
FAU - Bufe, A
AU  - Bufe A
FAU - Halken, S
AU  - Halken S
FAU - Beyer, K
AU  - Beyer K
FAU - Wahn, U
AU  - Wahn U
CN  - European Academy of Allergy and Clinical Immunology
LA  - eng
PT  - Consensus Development Conference
PT  - Journal Article
PT  - Review
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society
      of Pediatric Allergy and Immunology
JID - 9106718
SB  - IM
MH  - Asthma/immunology/therapy
MH  - Child
MH  - Desensitization, Immunologic/*methods/standards/*trends
MH  - Food Hypersensitivity/immunology/therapy
MH  - Humans
MH  - Practice Guidelines as Topic
MH  - Rhinitis/immunology/therapy
EDAT- 2012/05/19 06:00
MHDA- 2012/09/19 06:00
CRDT- 2012/05/19 06:00
PHST- 2012/05/19 06:00 [entrez]
PHST- 2012/05/19 06:00 [pubmed]
PHST- 2012/09/19 06:00 [medline]
AID - 10.1111/j.1399-3038.2012.01313.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2012 Jun;23(4):300-6. doi:
      10.1111/j.1399-3038.2012.01313.x.


PMID- 22594754
OWN - NLM
STAT- MEDLINE
DCOM- 20120809
LR  - 20211021
IS  - 1541-0048 (Electronic)
IS  - 0090-0036 (Linking)
VI  - 102
IP  - 7
DP  - 2012 Jul
TI  - Research participation as work: comparing the perspectives of researchers and
      economically marginalized populations.
PG  - 1254-9
LID - 10.2105/AJPH.2011.300418 [doi]
AB  - We examined the historical and regulatory framework of research with human
      participants in the United States, and described some possible unintended
      consequences of this framework in the context of paying young injection drug
      users for their time participating in behavioral and medical research. We drew
      upon our own experiences while conducting a long-running epidemiological study of
      hepatitis C virus infection. We found that existing ethical and regulatory
      framings of research participation may lead to injustices from the perspectives
      of research participants. We propose considering research participation as a
      specialized form of work and the use of community advisory boards to facilitate
      discussion about appropriate compensation for research participation among
      economically marginalized populations.
FAU - Davidson, Peter
AU  - Davidson P
AD  - Departments of Epidemiology and Biostatistics and Social Sciences, University of 
      California, San Francisco (UCSF), CA, USA. pdavidson@ucsd.edu
FAU - Page, Kimberly
AU  - Page K
LA  - eng
GR  - R01 DA016017/DA/NIDA NIH HHS/United States
GR  - T32 DA023356/DA/NIDA NIH HHS/United States
GR  - 2R01DA016017-07/DA/NIDA NIH HHS/United States
GR  - 5T32DA02335603/DA/NIDA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120517
PL  - United States
TA  - Am J Public Health
JT  - American journal of public health
JID - 1254074
SB  - IM
MH  - Biomedical Research/economics/ethics
MH  - Humans
MH  - *Patient Selection/ethics
MH  - Poverty
MH  - *Research Personnel/ethics
MH  - Substance Abuse, Intravenous/economics/psychology
MH  - *Vulnerable Populations
PMC - PMC3478002
MID - NIHMS511652
EDAT- 2012/05/19 06:00
MHDA- 2012/08/10 06:00
CRDT- 2012/05/19 06:00
PHST- 2012/05/19 06:00 [entrez]
PHST- 2012/05/19 06:00 [pubmed]
PHST- 2012/08/10 06:00 [medline]
AID - 10.2105/AJPH.2011.300418 [doi]
PST - ppublish
SO  - Am J Public Health. 2012 Jul;102(7):1254-9. doi: 10.2105/AJPH.2011.300418. Epub
      2012 May 17.


PMID- 22594620
OWN - NLM
STAT- MEDLINE
DCOM- 20130114
LR  - 20120828
IS  - 1600-6143 (Electronic)
IS  - 1600-6135 (Linking)
VI  - 12
IP  - 9
DP  - 2012 Sep
TI  - Informed consent for living donation: a review of key empirical studies, ethical 
      challenges and future research.
PG  - 2273-80
LID - 10.1111/j.1600-6143.2012.04102.x [doi]
AB  - Given the organ scarcity, live organ donation is increasingly considered a viable
      alternative for kidney and liver transplantation. Yet living donation challenges 
      the ethical principle of nonmaleficence by subjecting healthy individuals to
      medical, psychosocial and unknown risks. Therefore, transplant providers,
      policy-makers and donors are committed to ensuring that prospective donors
      provide adequate informed consent to undergo the procedure. Informed consent for 
      living donation is ethically required as a means of demonstrating respect for
      donor's autonomy and protecting their safety. However, all elements of informed
      consent are fraught with difficulties due to the unique nature of the donation
      process and outcome. This paper reviews empirical research on informed consent
      for live kidney donors (LKD) and live liver donors (LLD) for both adult and
      pediatric recipients. As this review shows, studies that empirically assessed the
      quality of informed consent elements reveal considerable variability and
      deficiencies across the informed consent process, suggesting the need for
      improvement. This review highlights challenges to each element of consent for
      both LKDs and LLDs, and situates trends within broader policy contexts, ethical
      debates and avenues for future innovative research.
CI  - (c) Copyright 2012 The American Society of Transplantation and the American
      Society of Transplant Surgeons.
FAU - Gordon, E J
AU  - Gordon EJ
AD  - Institute for Healthcare Studies, Comprehensive Transplant Center, Northwestern
      University Transplant Outcomes Research Collaborative, Feinberg School of
      Medicine, Northwestern University, Chicago, IL, USA. e-gordon@northwestern.edu
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120517
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
SB  - IM
MH  - Altruism
MH  - Decision Making
MH  - Empirical Research
MH  - Humans
MH  - *Informed Consent
MH  - *Living Donors
MH  - *Tissue and Organ Procurement/ethics
EDAT- 2012/05/19 06:00
MHDA- 2013/01/15 06:00
CRDT- 2012/05/19 06:00
PHST- 2012/05/19 06:00 [entrez]
PHST- 2012/05/19 06:00 [pubmed]
PHST- 2013/01/15 06:00 [medline]
AID - 10.1111/j.1600-6143.2012.04102.x [doi]
PST - ppublish
SO  - Am J Transplant. 2012 Sep;12(9):2273-80. doi: 10.1111/j.1600-6143.2012.04102.x.
      Epub 2012 May 17.


PMID- 22594334
OWN - NLM
STAT- MEDLINE
DCOM- 20120912
LR  - 20220129
IS  - 1746-076X (Electronic)
IS  - 1746-0751 (Linking)
VI  - 7
IP  - 3
DP  - 2012 May
TI  - Disclosure and management of research findings in stem cell research and banking:
      policy statement.
PG  - 439-48
LID - 10.2217/rme.12.23 [doi]
AB  - Prompted by an increased interest of both research participants and the patient
      advocacy community in obtaining information about research outcomes and on the
      use of their biological samples; the international community has begun to debate 
      the emergence of an ethical 'duty' to return research results to participants.
      Furthermore, the use of new technologies (e.g., whole-genome and -exome
      sequencing) has revealed both genetic data and incidental findings with possible 
      clinical significance. These technologies together with the proliferation of
      biorepositories, provide a compelling rationale for governments and scientific
      institutions to adopt prospective policies. Given the scarcity of policies in the
      context of stem cell research, a discussion on the scientific, ethical and legal 
      implications of disclosing research results for research participants is needed. 
      We present the International Stem Forum Ethics Working Party's Policy Statement
      and trust that it will stimulate debate and meet the concerns of researchers and 
      research participants alike.
FAU - Isasi, Rosario
AU  - Isasi R
AD  - Center of Genomics & Policy, Faculty of Medicine, Department of Human Genetics,
      McGill University, Montreal, QC, Canada. rosario.isasi@mcgill.ca
FAU - Knoppers, Bartha M
AU  - Knoppers BM
FAU - Andrews, Peter W
AU  - Andrews PW
FAU - Bredenoord, Annelien
AU  - Bredenoord A
FAU - Colman, Alan
AU  - Colman A
FAU - Hin, Lee Eng
AU  - Hin LE
FAU - Hull, Sara
AU  - Hull S
FAU - Kim, Ock-Joo
AU  - Kim OJ
FAU - Lomax, Geoffrey
AU  - Lomax G
FAU - Morris, Clive
AU  - Morris C
FAU - Sipp, Douglas
AU  - Sipp D
FAU - Stacey, Glyn
AU  - Stacey G
FAU - Wahlstrom, Jan
AU  - Wahlstrom J
FAU - Zeng, Fanyi
AU  - Zeng F
CN  - International Stem Cell Forum Ethics Working Party
LA  - eng
GR  - G1001045/MRC_/Medical Research Council/United Kingdom
GR  - MC_QA137863/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Regen Med
JT  - Regenerative medicine
JID - 101278116
SB  - IM
MH  - Disclosure/*ethics
MH  - Health Planning Guidelines
MH  - Humans
MH  - *Policy
MH  - Stem Cell Research/*ethics
MH  - Tissue Banks/*ethics
EDAT- 2012/05/19 06:00
MHDA- 2012/09/13 06:00
CRDT- 2012/05/19 06:00
PHST- 2012/05/19 06:00 [entrez]
PHST- 2012/05/19 06:00 [pubmed]
PHST- 2012/09/13 06:00 [medline]
AID - 10.2217/rme.12.23 [doi]
PST - ppublish
SO  - Regen Med. 2012 May;7(3):439-48. doi: 10.2217/rme.12.23.


PMID- 22593178
OWN - NLM
STAT- MEDLINE
DCOM- 20140716
LR  - 20130820
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 39
IP  - 9
DP  - 2013 Sep
TI  - Rationality, religion and refusal of treatment in an ambulance revisited.
PG  - 587-90
LID - 10.1136/medethics-2011-100079 [doi]
AB  - In their recent article, Erbay et al considered whether a seriously injured
      patient should be able to refuse treatment if the refusal was based on a
      (mis)interpretation of religious doctrine. They argued that in such a case 'what 
      is important...is whether the teaching or philosophy used as a reference point
      has been in fact correctly perceived' (p 653). If it has not been, they asserted 
      that this eroded the patient's capacity to make an autonomous decision and that
      therefore, in such cases, it is the role of the healthcare professional (HCP) to 
      'assist patients to think more clearly and rationally' (p 653). There are,
      however, a number of problems with the reasons why Erbay et al suggest we should 
      help patients to rationalise their decisions and how HCPs should go about this.
      In this article, the author explores some of their main arguments regarding
      consent and rationality (particularly in relation to religious beliefs), as well 
      as Erbay et al's normative claim that HCPs have an obligation to promote autonomy
      by helping patients to come to a 'rational' decision. Ultimately, the author
      agrees that the (temporary) solution to the dilemma presented in this scenario
      (which was to insert an intravenous cannula into the patient in order to allow an
      infusion of fluids in the event that he changed his mind) seemed both pragmatic
      and ethically permissible. However, it is suggested that the arguments which
      underpin this conclusion in Erbay et al's article are largely unsound.
FAU - McMahon-Parkes, Kate
AU  - McMahon-Parkes K
AD  - University of the West of England, Faculty of Health and Life Sciences, Alexander
      Warehouse, Gloucester Docks, Gloucester, GL1 2LG, UK.
      kate.mcmahon-parkes@uwe.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20120516
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Ambulances
MH  - Decision Making/*ethics
MH  - Ethics, Clinical
MH  - Ethics, Medical
MH  - Humans
MH  - Informed Consent/ethics
MH  - Male
MH  - *Personal Autonomy
MH  - *Religion and Medicine
MH  - Treatment Refusal/*ethics
OTO - NOTNLM
OT  - Consent
OT  - allocation of organs/tissues
OT  - applied and professional ethics
OT  - autonomy
OT  - donation/procurement of organs/tissues
OT  - rationality
OT  - religious beliefs
OT  - religious ethics
OT  - treatment refusal
EDAT- 2012/05/18 06:00
MHDA- 2014/07/17 06:00
CRDT- 2012/05/18 06:00
PHST- 2012/05/18 06:00 [entrez]
PHST- 2012/05/18 06:00 [pubmed]
PHST- 2014/07/17 06:00 [medline]
AID - medethics-2011-100079 [pii]
AID - 10.1136/medethics-2011-100079 [doi]
PST - ppublish
SO  - J Med Ethics. 2013 Sep;39(9):587-90. doi: 10.1136/medethics-2011-100079. Epub
      2012 May 16.


PMID- 22593120
OWN - NLM
STAT- MEDLINE
DCOM- 20120813
LR  - 20161125
IS  - 1600-0455 (Electronic)
IS  - 0284-1851 (Linking)
VI  - 53
IP  - 5
DP  - 2012 Jun 1
TI  - Digital breast tomosynthesis (DBT): initial experience in a clinical setting.
PG  - 524-9
LID - 10.1258/ar.2012.120062 [doi]
AB  - BACKGROUND: Digital breast tomosynthesis (DBT) is a promising new technology.
      Some experimental clinical studies have shown positive results, but the future
      role and indications of this new technique, whether in a screening or clinical
      setting, need to be evaluated. PURPOSE: To compare digital mammography and DBT in
      a side-by-side feature analysis for cancer conspicuity, and to assess whether
      there is a potential additional value of DBT to standard state-of-the-art
      conventional imaging work-up with respect to detection of additional
      malignancies. MATERIAL AND METHODS: The study had ethics committee approval. A
      total of 129 women underwent 2D digital mammography including supplementary
      cone-down and magnification views and breast ultrasonography if indicated, as
      well as digital breast tomosynthesis. The indication for conventional imaging in 
      the clinical setting included a palpable lump in 30 (23%), abnormal mammographic 
      screening findings in 54 (42%), and surveillance in 45 (35%) of the women. The
      women were examined according to present guidelines, including spot-magnification
      views, ultrasonography, and needle biopsies, if indicated. The DBT examinations
      were interpreted several weeks after the conventional imaging without knowledge
      of the conventional imaging findings. In a later session, three radiologists
      performed a side-by-side feature analysis for cancer conspicuity in a sample of
      50 cases. RESULTS: State-of-the-art conventional imaging resulted in needle
      biopsy of 45 breasts, of which 20 lesions were benign and a total of 25 cancers
      were diagnosed. The remaining 84 women were dismissed with a normal/definitely
      benign finding and without indication for needle biopsy. The subsequent DBT
      interpretation found suspicious findings in four of these 84 women, and these
      four women had to be called back for repeated work-up with knowledge of the
      tomosynthesis findings. These delayed work-ups resulted in two cancers
      (increasing the cancer detection by 8%) and two false-positive findings. The
      side-by-side feature analysis showed higher conspicuity scores for tomosynthesis 
      compared to conventional 2D for cancers presenting as spiculated masses and
      distortions. CONCLUSION: Tomosynthesis is a promising new technique. Our
      preliminary clinical experience shows that there is a potential for increasing
      the sensitivity using this new technique, especially for cancers manifesting as
      spiculated masses and distortions.
FAU - Skaane, Per
AU  - Skaane P
AD  - Department of Radiology, Oslo University Hospital Ullevaal, University of Oslo,
      Norway. PERSKA@ous-hf.no
FAU - Gullien, Randi
AU  - Gullien R
FAU - Bjorndal, Hilde
AU  - Bjorndal H
FAU - Eben, Ellen B
AU  - Eben EB
FAU - Ekseth, Ulrika
AU  - Ekseth U
FAU - Haakenaasen, Unni
AU  - Haakenaasen U
FAU - Jahr, Gunnar
AU  - Jahr G
FAU - Jebsen, Ingvild Naess
AU  - Jebsen IN
FAU - Krager, Mona
AU  - Krager M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120516
PL  - England
TA  - Acta Radiol
JT  - Acta radiologica (Stockholm, Sweden : 1987)
JID - 8706123
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biopsy, Needle
MH  - Breast Neoplasms/*diagnostic imaging/pathology
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Imaging, Three-Dimensional/methods
MH  - Mammography/*methods
MH  - Middle Aged
MH  - Radiographic Image Enhancement/*methods
MH  - Radiographic Image Interpretation, Computer-Assisted/methods
MH  - Sensitivity and Specificity
MH  - Ultrasonography, Mammary
EDAT- 2012/05/18 06:00
MHDA- 2012/08/14 06:00
CRDT- 2012/05/18 06:00
PHST- 2012/05/18 06:00 [entrez]
PHST- 2012/05/18 06:00 [pubmed]
PHST- 2012/08/14 06:00 [medline]
AID - ar.2012.120062 [pii]
AID - 10.1258/ar.2012.120062 [doi]
PST - ppublish
SO  - Acta Radiol. 2012 Jun 1;53(5):524-9. doi: 10.1258/ar.2012.120062. Epub 2012 May
      16.


PMID- 22592624
OWN - NLM
STAT- MEDLINE
DCOM- 20121210
LR  - 20220408
IS  - 1432-0878 (Electronic)
IS  - 0302-766X (Linking)
VI  - 349
IP  - 2
DP  - 2012 Aug
TI  - Amniotic membrane: from structure and functions to clinical applications.
PG  - 447-58
LID - 10.1007/s00441-012-1424-6 [doi]
AB  - Amniotic membrane (AM) or amnion is a thin membrane on the inner side of the
      fetal placenta; it completely surrounds the embryo and delimits the amniotic
      cavity, which is filled by amniotic liquid. In recent years, the structure and
      function of the amnion have been investigated, particularly the pluripotent
      properties of AM cells, which are an attractive source for tissue
      transplantation. AM has anti-inflammatory, anti-bacterial, anti-viral and
      immunological characteristics, as well as anti-angiogenic and pro-apoptotic
      features. AM is a promoter of epithelialization and is a non-tumorigenic tissue
      and its use has no ethical problems. Because of its attractive properties, AM has
      been applied in several surgical procedures related to ocular surface
      reconstruction and the genito-urinary tract, skin, head and neck, among others.
      So far, the best known and most auspicious applications of AM are ocular surface 
      reconstruction, skin applications and tissue engineering. However, AM can also be
      applied in oncology. In this area, AM can prevent the delivery of nutrients and
      oxygen to cancer cells and consequently interfere with tumour angiogenesis,
      growth and metastasis.
FAU - Mamede, A C
AU  - Mamede AC
AD  - Biophysics Unit, IBILI, Faculty of Medicine, University of Coimbra, Coimbra,
      Portugal. ana_mamede@hotmail.com
FAU - Carvalho, M J
AU  - Carvalho MJ
FAU - Abrantes, A M
AU  - Abrantes AM
FAU - Laranjo, M
AU  - Laranjo M
FAU - Maia, C J
AU  - Maia CJ
FAU - Botelho, M F
AU  - Botelho MF
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120518
PL  - Germany
TA  - Cell Tissue Res
JT  - Cell and tissue research
JID - 0417625
SB  - IM
MH  - Amnion/*cytology/immunology/*transplantation
MH  - Animals
MH  - Humans
MH  - Ophthalmologic Surgical Procedures/methods
MH  - Reconstructive Surgical Procedures/*methods
MH  - Regenerative Medicine/*methods
MH  - Tissue Engineering/*methods
EDAT- 2012/05/18 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/05/18 06:00
PHST- 2012/01/18 00:00 [received]
PHST- 2012/03/25 00:00 [accepted]
PHST- 2012/05/18 06:00 [entrez]
PHST- 2012/05/18 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - 10.1007/s00441-012-1424-6 [doi]
PST - ppublish
SO  - Cell Tissue Res. 2012 Aug;349(2):447-58. doi: 10.1007/s00441-012-1424-6. Epub
      2012 May 18.


PMID- 22592104
OWN - NLM
STAT- MEDLINE
DCOM- 20120823
LR  - 20151119
IS  - 1948-965X (Electronic)
IS  - 1682-3141 (Linking)
VI  - 20
IP  - 2
DP  - 2012 Jun
TI  - Gender-related differences in the human rights needs of patients with mental
      illness.
PG  - 90-8
LID - 10.1097/jnr.0b013e318257b57b [doi]
AB  - BACKGROUND: Individuals with mental illness commonly experience human rights
      violations while seeking to meet their basic needs. There is lack of research in 
      developing countries on gender-related differences in human rights needs.
      PURPOSE: This study investigated gender differences in perceived human rights
      needs at the family and community levels in individuals with mental illness in
      India. METHODS: This descriptive study surveyed 100 asymptomatic individuals with
      mental illness at a tertiary care center. Subject selection employed a random
      sampling method. Data were collected using face-to-face interviews based on a
      structured needs assessment questionnaire. Data were analyzed and interpreted
      using descriptive and inferential statistics. RESULTS: Subjects enjoyed a
      satisfactory level of fulfillment in the physical dimension of human rights
      needs, which included food, housing, and clothing. Men expressed lower
      satisfaction than women with perceived human rights needs fulfillment in the
      emotional dimension. This included fear of family members (chi = 9.419, p < .024)
      and being called derogatory names (chi = 8.661, p < .034). Women expressed lower 
      satisfaction than men with perceived human rights needs fulfillment in social and
      ethical dimensions. The former included freedom to leave the home (chi = 11.277, 
      p < .010), and the latter included sexual abuse by family members (chi = 9.491, p
      < .019). Men felt more discriminated than women due to perceptions of mental
      illness in the community domain (chi = 10.197, p < .037). CONCLUSION: This study 
      suggests that family members and communities need to be educated regarding the
      human rights needs of people with mental illness and that legislation must be
      strengthened to meet the human rights needs of this disadvantaged population.
FAU - Vijayalakshmi, Poreddi
AU  - Vijayalakshmi P
AD  - Department of Nursing, National Institute of Mental Health and Neuro Sciences,
      Deemed University, Bangalore, India. pvijayalakshmireddy@gmail.com
FAU - Reddemma, Konduru
AU  - Reddemma K
FAU - Math, Suresh Bada
AU  - Math SB
LA  - eng
PT  - Journal Article
PL  - China (Republic : 1949- )
TA  - J Nurs Res
JT  - The journal of nursing research : JNR
JID - 101128757
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Family Relations
MH  - Female
MH  - Healthcare Disparities/*standards/statistics & numerical data
MH  - Human Rights/*psychology/statistics & numerical data
MH  - Humans
MH  - India
MH  - Male
MH  - *Men's Health
MH  - Mental Disorders/complications/*diagnosis/physiopathology
MH  - Mental Health Services/ethics/legislation & jurisprudence/*standards
MH  - Middle Aged
MH  - *Needs Assessment/ethics/statistics & numerical data
MH  - Patient Satisfaction/statistics & numerical data
MH  - Psychiatric Status Rating Scales
MH  - Psychometrics/instrumentation
MH  - Residence Characteristics/statistics & numerical data
MH  - Sex Factors
MH  - *Social Class
MH  - Surveys and Questionnaires
MH  - *Women's Health
EDAT- 2012/05/18 06:00
MHDA- 2012/08/24 06:00
CRDT- 2012/05/18 06:00
PHST- 2012/05/18 06:00 [entrez]
PHST- 2012/05/18 06:00 [pubmed]
PHST- 2012/08/24 06:00 [medline]
AID - 10.1097/jnr.0b013e318257b57b [doi]
AID - 00134372-201206000-00004 [pii]
PST - ppublish
SO  - J Nurs Res. 2012 Jun;20(2):90-8. doi: 10.1097/jnr.0b013e318257b57b.


PMID- 22592066
OWN - NLM
STAT- MEDLINE
DCOM- 20121004
LR  - 20120517
IS  - 1557-0584 (Electronic)
IS  - 1557-0576 (Linking)
VI  - 36
IP  - 2
DP  - 2012 Jun
TI  - Ethical issues in brain-computer interface research, development, and
      dissemination.
PG  - 94-9
LID - 10.1097/NPT.0b013e31825064cc [doi]
AB  - The steadily growing field of brain-computer interfacing (BCI) may develop useful
      technologies, with a potential impact not only on individuals, but also on
      society as a whole. At the same time, the development of BCI presents significant
      ethical and legal challenges. In a workshop during the 4th International BCI
      meeting (Asilomar, California, 2010), six panel members from various BCI
      laboratories and companies set out to identify and disentangle ethical issues
      related to BCI use in four case scenarios, which were inspired by current
      experiences in BCI laboratories. Results of the discussion are reported in this
      article, touching on topics such as the representation of persons with
      communication impairments, dealing with technological complexity and moral
      responsibility in multidisciplinary teams, and managing expectations, ranging
      from an individual user to the general public. Furthermore, we illustrate that
      where treatment and research interests conflict, ethical concerns arise. On the
      basis of the four case scenarios, we discuss salient, practical ethical issues
      that may confront any member of a typical multidisciplinary BCI team. We
      encourage the BCI and rehabilitation communities to engage in a dialogue, and to 
      further identify and address pressing ethical issues as they occur in the
      practice of BCI research and its commercial applications.
FAU - Vlek, Rutger J
AU  - Vlek RJ
AD  - Radboud University Nijmegen, Donders Institute for Brain, Cognition and
      Behaviour, The Netherlands.
FAU - Steines, David
AU  - Steines D
FAU - Szibbo, Dyana
AU  - Szibbo D
FAU - Kubler, Andrea
AU  - Kubler A
FAU - Schneider, Mary-Jane
AU  - Schneider MJ
FAU - Haselager, Pim
AU  - Haselager P
FAU - Nijboer, Femke
AU  - Nijboer F
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurol Phys Ther
JT  - Journal of neurologic physical therapy : JNPT
JID - 101193365
SB  - IM
MH  - *Biomedical Research/ethics/instrumentation/trends
MH  - Brain Diseases/*rehabilitation
MH  - *Communication Aids for Disabled
MH  - Education/*methods
MH  - Humans
MH  - *User-Computer Interface
EDAT- 2012/05/18 06:00
MHDA- 2012/10/05 06:00
CRDT- 2012/05/18 06:00
PHST- 2012/05/18 06:00 [entrez]
PHST- 2012/05/18 06:00 [pubmed]
PHST- 2012/10/05 06:00 [medline]
AID - 10.1097/NPT.0b013e31825064cc [doi]
AID - 01253086-201206000-00008 [pii]
PST - ppublish
SO  - J Neurol Phys Ther. 2012 Jun;36(2):94-9. doi: 10.1097/NPT.0b013e31825064cc.


PMID- 22591978
OWN - NLM
STAT- MEDLINE
DCOM- 20120628
LR  - 20220318
IS  - 0888-5109 (Print)
IS  - 0888-5109 (Linking)
VI  - 27
IP  - 5
DP  - 2012 May
TI  - Tablet splitting: a review of weight and content uniformity.
PG  - 341-52
LID - 10.4140/TCP.n.2012.341 [doi]
AB  - OBJECTIVE: To describe the product integrity and ethical/ legal issues associated
      with tablet splitting. DATA SOURCES: PubMed (1966-June 2011), International
      Pharmaceutical Abstract (1975-June 2011), and bibliographic searches were
      conducted. STUDY SELECTION: All studies that evaluated the weight/dose variations
      (N = 13) of split tablets were included. DATA EXTRACTION: The American
      Pharmacists Association guidelines, recommendations from the Food and Drug
      Administration, and clinical studies evaluating product integrity of split
      tablets were used to provide an overview of issues related to this practice.
      Legal considerations from various sources were also included. DATA SYNTHESIS: The
      practice of tablet splitting is increasing and is associated with variations in
      drug distributions related to the tablet-splitting technique and other causes.
      The first part of this two-part series will evaluate the product integrity and
      practice-related issues associated with tablet splitting. CONCLUSION: The
      majority of the studies associated with tablet splitting reveal large
      fluctuations in weight/dosage, but few studies evaluate variability with narrow
      therapeutic index medications. Therefore, the clinical impact of these variations
      is not globally applicable across medication classes. Although tablet splitting
      has the potential to save patients and health care organizations a significant
      amount of money, appropriateness of tablet splitting should be determined for
      individual medications and individual patients. Assessments should include an
      evaluation of patient understanding and physical abilities for tablet splitting.
FAU - Freeman, Maisha Kelly
AU  - Freeman MK
AD  - Samford University Global Drug Information Service, McWhorter School of Pharmacy,
      Birmingham, AL, USA.
FAU - White, Whitney
AU  - White W
FAU - Iranikhah, Maryam
AU  - Iranikhah M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Consult Pharm
JT  - The Consultant pharmacist : the journal of the American Society of Consultant
      Pharmacists
JID - 9013983
RN  - 0 (Pharmaceutical Preparations)
RN  - 0 (Tablets)
SB  - IM
MH  - Drug Costs
MH  - Drug Stability
MH  - Drug Therapy
MH  - Guidelines as Topic
MH  - Humans
MH  - Legislation, Drug
MH  - Patient Education as Topic
MH  - Pharmaceutical Preparations/administration & dosage
MH  - Tablets/economics/*standards
MH  - United States
EDAT- 2012/05/18 06:00
MHDA- 2012/06/29 06:00
CRDT- 2012/05/18 06:00
PHST- 2012/05/18 06:00 [entrez]
PHST- 2012/05/18 06:00 [pubmed]
PHST- 2012/06/29 06:00 [medline]
AID - Q37854711354168M [pii]
AID - 10.4140/TCP.n.2012.341 [doi]
PST - ppublish
SO  - Consult Pharm. 2012 May;27(5):341-52. doi: 10.4140/TCP.n.2012.341.


PMID- 22591932
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20120517
IS  - 1049-023X (Print)
IS  - 1049-023X (Linking)
VI  - 27
IP  - 1
DP  - 2012 Feb
TI  - The ethics of resuscitation: how do paramedics experience ethical dilemmas when
      faced with cancer patients with cardiac arrest?
PG  - 64-70
LID - 10.1017/S1049023X1200026X [doi]
AB  - INTRODUCTION: Research on prehospital emergency work traditionally has focused on
      medical issues, but paramedics often have to make ethical choices. The goal of
      this exploratory study was to understand how paramedics experience difficult
      ethical dilemmas regarding resuscitation of cancer patients. METHODS: Paramedics 
      from ambulance services in Norway were interviewed about resuscitation of cancer 
      patients with cardiac arrest. The qualitative study included naturalistic,
      semi-structured interviews and a cognitive-emotional, interpretive approach.
      RESULTS: All study participants believed that it ethically can be correct not to 
      resuscitate if the patient is expected to survive for only a short time with a
      very low quality of life and severe negative illness experiences. However, this
      belief sometimes failed to match formal or informal guidelines and contextual
      factors such as expectations of relatives. When confronting these challenges, the
      majority of the paramedics relied heavily on the advice of medical experts, but
      some had to make more autonomous decisions. DISCUSSION: The concept of a double
      pressure situation can be used to analyze the ethical dilemmas regarding
      resuscitation of cancer patients. The pressure from "below" is grounded in
      individual caring frameworks, and in the belief that it can be wrong to
      resuscitate. The pressure from "above" is objective and system-related, related
      to uncertainty, and grounded in the fundamental and irreducible value of human
      life. CONCLUSIONS: The findings of this qualitative, exploratory study suggest
      that ethical concepts and analyses of double pressure situations should have an
      important role in education and training designed to prepare emergency personnel 
      for difficult life and death choices. More research is needed to shed light on
      how ethical dilemmas arise in prehospital work.
FAU - Nordby, Halvor
AU  - Nordby H
AD  - Department of Health and Society, University of Oslo, Oslo, Norway.
      halvor.nordby@medisin.uio.no
FAU - Nohr, Oyvind
AU  - Nohr O
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Prehosp Disaster Med
JT  - Prehospital and disaster medicine
JID - 8918173
MH  - Adult
MH  - Allied Health Personnel/*ethics
MH  - Cardiopulmonary Resuscitation/*ethics
MH  - Decision Making/*ethics
MH  - Female
MH  - Heart Arrest/*etiology/*therapy
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Neoplasms/*complications
MH  - Norway
EDAT- 2012/05/18 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/05/18 06:00
PHST- 2012/05/18 06:00 [entrez]
PHST- 2012/05/18 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
AID - S1049023X1200026X [pii]
AID - 10.1017/S1049023X1200026X [doi]
PST - ppublish
SO  - Prehosp Disaster Med. 2012 Feb;27(1):64-70. doi: 10.1017/S1049023X1200026X.


PMID- 22591930
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20220409
IS  - 1049-023X (Print)
IS  - 1049-023X (Linking)
VI  - 27
IP  - 1
DP  - 2012 Feb
TI  - Balancing between closeness and distance: emergency medical services personnel's 
      experiences of caring for families at out-of-hospital cardiac arrest and sudden
      death.
PG  - 42-52
LID - 10.1017/S1049023X12000167 [doi]
AB  - INTRODUCTION: Out-of-hospital cardiac arrest (OHCA) is a lethal health problem
      that affects between 236,000 and 325,000 people in the United States each year.
      As resuscitation attempts are unsuccessful in 70-98% of OHCA cases, Emergency
      Medical Services (EMS) personnel often face the needs of bereaved family members.
      PROBLEM: Decisions to continue or terminate resuscitation at OHCA are influenced 
      by factors other than patient clinical characteristics, such as EMS personnel's
      knowledge, attitudes, and beliefs regarding family emotional preparedness.
      However, there is little research exploring how EMS personnel care for bereaved
      family members, or how they are affected by family dynamics and the emotional
      contexts. The aim of this study is to analyze EMS personnel's experiences of
      caring for families when patients suffer cardiac arrest and sudden death.
      METHODS: The study is based on a hermeneutic lifeworld approach. Qualitative
      interviews were conducted with 10 EMS personnel from an EMS agency in southern
      Sweden. RESULTS: The EMS personnel interviewed felt responsible for both patient 
      care and family care, and sometimes failed to prioritize these responsibilities
      as a result of their own perceptions, feelings and reactions. Moving from patient
      care to family care implied a movement from well-structured guidance to a
      situational response, where the personnel were forced to balance between
      interpretive reasoning and a more direct emotional response, at their own
      discretion. With such affective responses in decision-making, the personnel
      risked erroneous conclusions and care relationships with elements of dishonesty, 
      misguided benevolence and false hopes. The ability to recognize and respond to
      people's existential questions and needs was essential. It was dependent on the
      EMS personnel's balance between closeness and distance, and on their courage in
      facing the emotional expressions of the families, as well as the personnel's own 
      vulnerability. The presence of family members placed great demands on mobility
      (moving from patient care to family care) in the decision-making process,
      invoking a need for ethical competence. CONCLUSION: Ethical caring competence is 
      needed in the care of bereaved family members to avoid additional suffering.
      Opportunities to reflect on these situations within a framework of care ethics,
      continuous moral education, and clinical ethics training are needed. Support in
      dealing with personal discomfort and clear guidelines on family support could
      benefit EMS personnel.
FAU - Bremer, Anders
AU  - Bremer A
AD  - School of Health Sciences, University of Boras, Boras, Sweden.
      anders.bremer@hb.se
FAU - Dahlberg, Karin
AU  - Dahlberg K
FAU - Sandman, Lars
AU  - Sandman L
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Prehosp Disaster Med
JT  - Prehospital and disaster medicine
JID - 8918173
MH  - Adult
MH  - *Cardiopulmonary Resuscitation
MH  - *Death, Sudden, Cardiac
MH  - Emergency Medical Technicians/ethics/*psychology
MH  - Female
MH  - Humans
MH  - Interviews as Topic
MH  - Male
MH  - Middle Aged
MH  - Out-of-Hospital Cardiac Arrest/*mortality/therapy
MH  - *Professional-Family Relations
MH  - Qualitative Research
MH  - Sweden
MH  - *Travel
EDAT- 2012/05/18 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/05/18 06:00
PHST- 2012/05/18 06:00 [entrez]
PHST- 2012/05/18 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
AID - S1049023X12000167 [pii]
AID - 10.1017/S1049023X12000167 [doi]
PST - ppublish
SO  - Prehosp Disaster Med. 2012 Feb;27(1):42-52. doi: 10.1017/S1049023X12000167.


PMID- 22591877
OWN - NLM
STAT- MEDLINE
DCOM- 20120710
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 9
IP  - 2
DP  - 2012 Apr-Jun
TI  - Ethics in burns surgery: when is enough, enough?
PG  - 126-8
AB  - Patients with extensive burns injuries are often given a poor prognosis. Those
      who survive after an initial early resuscitation phase often require extensive
      operative and critical care input, a prolonged hospital stay, and associated
      significant complications. The overwhelmingly high volume of patients already
      using the resource-stricken burns care service places extreme pressure on
      clinicians in respect of decisions they make about who should and should not be
      resuscitated. In this paper, we present the case of a young woman who sustained
      significant burn injuries, and discuss the ethical dilemmas encountered during
      the subsequent management of her care.
FAU - Kong, Victor
AU  - Kong V
AD  - Burns Unit, Edendale Hospital, Pietermaritzburg, South Africa.
      victorywkong@yahoo.com
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Adult
MH  - Burns/diagnosis/*surgery/therapy
MH  - Decision Making/*ethics
MH  - Female
MH  - Health Care Rationing/*ethics
MH  - Humans
MH  - India
MH  - Prognosis
MH  - Resuscitation Orders/*ethics
EDAT- 2012/05/18 06:00
MHDA- 2012/07/11 06:00
CRDT- 2012/05/18 06:00
PHST- 2012/05/18 06:00 [entrez]
PHST- 2012/05/18 06:00 [pubmed]
PHST- 2012/07/11 06:00 [medline]
AID - http://ijme.in/202cs126.html [pii]
AID - 10.20529/IJME.2012.039 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2012 Apr-Jun;9(2):126-8. doi: 10.20529/IJME.2012.039.


PMID- 22591876
OWN - NLM
STAT- MEDLINE
DCOM- 20120710
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 9
IP  - 2
DP  - 2012 Apr-Jun
TI  - Treating a homeless psychiatric patient: ethical challenges.
PG  - 124-6
FAU - David, Kirubah V
AU  - David KV
AD  - Low Cost Effective Care Unit, Department of Family Medicine, Christian Medical
      College, Vellore 632 001, India. kirubahc@gmail.com
FAU - John, Sushil Mathew
AU  - John SM
FAU - Venkatesan, S
AU  - Venkatesan S
FAU - Bhattacharji, Sarah
AU  - Bhattacharji S
FAU - Tharyan, Anna
AU  - Tharyan A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Coma/*therapy
MH  - Decision Making/*ethics
MH  - *Homeless Persons
MH  - Humans
MH  - Male
MH  - Mental Disorders/*therapy
MH  - Resuscitation Orders/ethics
MH  - Social Responsibility
MH  - Terminal Care/*ethics
EDAT- 2012/05/18 06:00
MHDA- 2012/07/11 06:00
CRDT- 2012/05/18 06:00
PHST- 2012/05/18 06:00 [entrez]
PHST- 2012/05/18 06:00 [pubmed]
PHST- 2012/07/11 06:00 [medline]
AID - http://ijme.in/202cs124.html [pii]
AID - 10.20529/IJME.2012.038 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2012 Apr-Jun;9(2):124-6. doi: 10.20529/IJME.2012.038.


PMID- 22591868
OWN - NLM
STAT- MEDLINE
DCOM- 20120710
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 9
IP  - 2
DP  - 2012 Apr-Jun
TI  - Completeness of consent forms in research proposals submitted to an ethics review
      committee.
PG  - 100-3
AB  - This was a descriptive cross-sectional study which analysed the consent forms
      submitted to the ethics review committee at the faculty of medicine of the
      University of Kelaniya, Sri Lanka, between January 2007 and December 2008. Of the
      145 consent forms reviewed, 94.5% (137) explained the purpose of the study, 77%
      (111) included a statement that participation was voluntary, 44% (64) stated that
      refusal of participation did not affect care, 65.5% (95) mentioned the ability to
      withdraw consent at any time, 79% (115) that confidentiality of records would be 
      maintained and 45.5% (66) that further clarifications were possible. Thirty nine 
      (75%) of 52 eligible consent forms described the potential benefits and 19% (18) 
      of 93 consent forms explained that there were no benefits to the participants.
      Twenty eight (59%) of 47 eligible consent forms described possible risks or
      discomfort to patients and 30% (29) of 98 consent forms explained that there were
      no risks to the participants. In conclusion, essential elements of the consent
      forms were missing in this study. It is recommended that a checklist of
      compulsory elements to include on forms be used before proposals are submitted to
      an ethics review committee.
FAU - Abeysena, Chrishantha
AU  - Abeysena C
AD  - Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama,
      Sri Lanka. chrishantha-abeysena@mfac.kln.ac.lk
FAU - Jayamanna, Kanchana
AU  - Jayamanna K
FAU - Dep, Sajeev
AU  - Dep S
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Cross-Sectional Studies
MH  - Ethics Committees, Research
MH  - Forms and Records Control/*standards
MH  - Humans
MH  - Informed Consent/*ethics
MH  - Research Design/*standards
MH  - Sri Lanka
EDAT- 2012/05/18 06:00
MHDA- 2012/07/11 06:00
CRDT- 2012/05/18 06:00
PHST- 2012/05/18 06:00 [entrez]
PHST- 2012/05/18 06:00 [pubmed]
PHST- 2012/07/11 06:00 [medline]
AID - http://ijme.in/202ar100.html [pii]
AID - 10.20529/IJME.2012.030 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2012 Apr-Jun;9(2):100-3. doi: 10.20529/IJME.2012.030.


PMID- 22591867
OWN - NLM
STAT- MEDLINE
DCOM- 20120710
LR  - 20171223
IS  - 0974-8466 (Print)
IS  - 0974-8466 (Linking)
VI  - 9
IP  - 2
DP  - 2012 Apr-Jun
TI  - Awareness of medical ethics among undergraduates in a West Bengal medical
      college.
PG  - 93-100
AB  - This descriptive, cross-sectional study was conducted to assess the knowledge of 
      and attitudes towards medical ethics among undergraduate medical students. It
      also looked at whether there was any improvement with additional years of medical
      education. 340 medical students of a medical college in West Bengal were given a 
      semi-structured questionnaire that included questions regarding their awareness
      of ethics, their attitudes towards various issues in clinical ethics, and their
      knowledge of the code of medical ethics of the West Bengal Medical Council. The
      responses of 322 students were analysed by simple descriptive statistics. The
      students generally agreed that awareness of ethics was important. Lectures
      (54.7%) and books (47.8%) were their predominant sources of knowledge. Only 10.9 
      % were aware of the existence of an institutional ethics committee and 42.8% did 
      not know its exact role. Their answers showed that the majority of students
      expressed mixed responses--both desirable and undesirable--in relation to
      questions exploring different aspects of basic ethical reasoning in their
      professional life. The most desirable response for each statement was decided by 
      experts of forensic medicine and also from a literature study. Only half the
      respondents (50.9%) had a good score (61-70 out of a total possible 90) and 37.2%
      had a fair score (51-60). There was no increase in scores corresponding with
      additional years of medical education.
FAU - Chatterjee, Biswajit
AU  - Chatterjee B
AD  - Department of Community Medicine, Midnapore Medical College, Paschim
      Medinipur,West Bengal 721 101, India. biswajit.bapin@gmail.com
FAU - Sarkar, Jhuma
AU  - Sarkar J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - India
TA  - Indian J Med Ethics
JT  - Indian journal of medical ethics
JID - 101214913
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cross-Sectional Studies
MH  - *Education, Medical, Undergraduate
MH  - Ethics, Medical/*education
MH  - Female
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - India
MH  - Male
EDAT- 2012/05/18 06:00
MHDA- 2012/07/11 06:00
CRDT- 2012/05/18 06:00
PHST- 2012/05/18 06:00 [entrez]
PHST- 2012/05/18 06:00 [pubmed]
PHST- 2012/07/11 06:00 [medline]
AID - http://ijme.in/202ar93.html [pii]
AID - 10.20529/IJME.2012.029 [doi]
PST - ppublish
SO  - Indian J Med Ethics. 2012 Apr-Jun;9(2):93-100. doi: 10.20529/IJME.2012.029.


PMID- 22591762
OWN - NLM
STAT- MEDLINE
DCOM- 20130226
LR  - 20191210
IS  - 1872-9126 (Electronic)
IS  - 0003-6870 (Linking)
VI  - 44
IP  - 1
DP  - 2013 Jan
TI  - Validating a low cost approach for predicting human responses to emergency
      situations.
PG  - 27-34
LID - 10.1016/j.apergo.2012.04.005 [doi]
LID - S0003-6870(12)00055-5 [pii]
AB  - This paper presents a new approach for predicting human responses to emergency
      situations. The approach was developed for ergonomists working in emergency
      response preparedness. It involves presenting participants with a description of 
      a hypothetical emergency scenario before asking them to describe how they would
      respond. This study builds upon previous investigations (Lawson et al., 2009a,
      2009b; Lawson, 2011) which demonstrated significant associations between the
      predicted behaviour and that reported in a reference study of behaviour in real
      fires. This further work aimed to evaluate in greater detail the validity,
      reliability, resources and ethics of the approach. The results demonstrated
      significant relationships between the predicted behaviours and those from the
      reference study for both frequencies (r(s) = 0.572, N = 51, p < 0.001) and
      sequences (r(s) = 0.344, N = 40, p < 0.05) of behaviour. The approach is shown to
      be replicable and requires low resources. It does not present any notable risk of
      physical injury.
CI  - Copyright (c) 2012 Elsevier Ltd and The Ergonomics Society. All rights reserved.
FAU - Lawson, Glyn
AU  - Lawson G
AD  - Human Factors Research Group, Faculty of Engineering, The University of
      Nottingham, Nottingham NG7 2RD, United Kingdom. glyn.lawson@nottingham.ac.uk
FAU - Sharples, Sarah
AU  - Sharples S
FAU - Clarke, David
AU  - Clarke D
FAU - Cobb, Sue
AU  - Cobb S
LA  - eng
PT  - Journal Article
PT  - Validation Study
DEP - 20120515
PL  - England
TA  - Appl Ergon
JT  - Applied ergonomics
JID - 0261412
SB  - IM
MH  - Adult
MH  - *Behavior
MH  - Decision Making
MH  - *Emergencies
MH  - Emergency Responders/psychology
MH  - England
MH  - Female
MH  - Fires
MH  - Humans
MH  - Male
MH  - Predictive Value of Tests
MH  - *Task Performance and Analysis
MH  - Young Adult
EDAT- 2012/05/18 06:00
MHDA- 2013/02/27 06:00
CRDT- 2012/05/18 06:00
PHST- 2011/10/11 00:00 [received]
PHST- 2012/04/11 00:00 [revised]
PHST- 2012/04/16 00:00 [accepted]
PHST- 2012/05/18 06:00 [entrez]
PHST- 2012/05/18 06:00 [pubmed]
PHST- 2013/02/27 06:00 [medline]
AID - S0003-6870(12)00055-5 [pii]
AID - 10.1016/j.apergo.2012.04.005 [doi]
PST - ppublish
SO  - Appl Ergon. 2013 Jan;44(1):27-34. doi: 10.1016/j.apergo.2012.04.005. Epub 2012
      May 15.


PMID- 22591749
OWN - NLM
STAT- MEDLINE
DCOM- 20140804
LR  - 20131111
IS  - 1873-2496 (Electronic)
IS  - 1078-1439 (Linking)
VI  - 31
IP  - 8
DP  - 2013 Nov
TI  - The prognostic value of transrectal ultrasound guided biopsy in patients over 70 
      years old with a prostate specific Antigen (PSA) level </= 15 ng/ml and normal
      digital rectal examination: a 10-year prospective follow-up study of 427
      consecutive patients.
PG  - 1489-96
LID - 10.1016/j.urolonc.2012.04.005 [doi]
LID - S1078-1439(12)00136-6 [pii]
AB  - INTRODUCTION: As a urologist, it is common to review a patient above the age of
      70 being referred to a prostate assessments clinic with an elevated PSA. We
      evaluate the prognosis of these patients clinically as there is no international 
      consensus on the exact PSA cutoff level or a single international guideline as to
      when these patients should be offered a prostate biopsy. PATIENTS AND METHODS: On
      receiving ethic committee approval, we recruited 427 consecutive patients aged 70
      years and above referred with a PSA of >/= 4 ng/ml, from January 1996 to December
      2000, into our study. All patients were assessed, examined with a digital rectal 
      examination (DRE) of the prostate, and a subsequent prostate biopsy. We followed 
      up on their histologic diagnosis for up to 10 years and analyzed their outcome.
      The main outcome measures were disease-free survival and overall survival,
      stratified according to the PSA level (</= 15 vs. >15 ng/ml) and DRE findings
      (normal vs. sbnormal). RESULTS: There was a statistically significant difference 
      in the overall survival (P value < 0.011) and disease specific survival (P value 
      < 0.0001) of cancer patients with a PSA was >15 ng/ml and an abnormal DRE.
      However, in patients with a PSA </= 15 ng/ml and normal DRE, the incidence of
      cancer was low and they had no disease-specific or overall survival benefit.
      CONCLUSIONS: A policy of deferring prostate biopsy in patients with a PSA </= 15 
      ng/ml and normal DRE (Group A) would significantly decrease the need of
      unnecessary prostate biopsies. Within this group, patients did not have any
      survival advantage compared with those without cancer. We conclude that up to 20%
      of the prostate biopsies performed in this age group could have been avoided.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Mohamed, Zakir K
AU  - Mohamed ZK
AD  - Department of Urology, Sunderland Royal Hospital, UK.
FAU - Dominguez-Escrig, Jose
AU  - Dominguez-Escrig J
FAU - Vasdev, Nikhil
AU  - Vasdev N
FAU - Bharathan, Balamurali
AU  - Bharathan B
FAU - Greene, Damian
AU  - Greene D
LA  - eng
PT  - Journal Article
DEP - 20120515
PL  - United States
TA  - Urol Oncol
JT  - Urologic oncology
JID - 9805460
RN  - EC 3.4.21.77 (Prostate-Specific Antigen)
SB  - IM
MH  - Aged
MH  - Biopsy
MH  - *Digital Rectal Examination
MH  - Disease-Free Survival
MH  - Follow-Up Studies
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Prognosis
MH  - Prospective Studies
MH  - Prostate/*pathology
MH  - Prostate-Specific Antigen/*blood
MH  - Prostatic Neoplasms/blood/diagnosis/*pathology
MH  - Time Factors
MH  - Ultrasound, High-Intensity Focused, Transrectal
OTO - NOTNLM
OT  - PSA
OT  - Prostate cancer
EDAT- 2012/05/18 06:00
MHDA- 2014/08/05 06:00
CRDT- 2012/05/18 06:00
PHST- 2011/01/07 00:00 [received]
PHST- 2012/03/24 00:00 [revised]
PHST- 2012/04/04 00:00 [accepted]
PHST- 2012/05/18 06:00 [entrez]
PHST- 2012/05/18 06:00 [pubmed]
PHST- 2014/08/05 06:00 [medline]
AID - S1078-1439(12)00136-6 [pii]
AID - 10.1016/j.urolonc.2012.04.005 [doi]
PST - ppublish
SO  - Urol Oncol. 2013 Nov;31(8):1489-96. doi: 10.1016/j.urolonc.2012.04.005. Epub 2012
      May 15.


PMID- 22591229
OWN - NLM
STAT- MEDLINE
DCOM- 20140429
LR  - 20121106
IS  - 1365-2850 (Electronic)
IS  - 1351-0126 (Linking)
VI  - 19
IP  - 10
DP  - 2012 Dec
TI  - The book, the stories, the people: an ongoing dialogic narrative inquiry study
      combining a practice development project. Part 2: the practice development
      context.
PG  - 950-7
LID - 10.1111/j.1365-2850.2012.01921.x [doi]
AB  - This paper is the second part of a two-article practice development report. It
      builds on the first part by introducing and discussing a Writing for Recovery
      practice development project, conducted at two UK sites. The paper begins by
      briefly describing the project within the context of helping mental health users,
      carers and survivors develop skills in creative writing in order to engage in the
      process of narrative re-storying in line with preferred identity. A selective
      overview of broad and focal background literature relevant to the project is then
      provided in order to position it within a values-based mental health nursing
      practice. Following this, the specific plan for running the project is briefly
      summarized, covering actual and anticipated ethical issues. The paper ends with a
      discussion of dissemination aims.
CI  - (c) 2012 Blackwell Publishing.
FAU - Grant, A
AU  - Grant A
AD  - School of Nursing and Midwifery, University of Brighton, East Sussex, UK.
      a.grant@bton.ac.uk
FAU - Biley, F C
AU  - Biley FC
FAU - Leigh-Phippard, H
AU  - Leigh-Phippard H
FAU - Walker, H
AU  - Walker H
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Review
DEP - 20120517
PL  - England
TA  - J Psychiatr Ment Health Nurs
JT  - Journal of psychiatric and mental health nursing
JID - 9439514
MH  - Advanced Practice Nursing/methods/*standards
MH  - Humans
MH  - Mental Disorders/therapy
MH  - Narration
MH  - Program Development/methods/*standards
MH  - Psychiatric Nursing/methods/*standards
MH  - Writing
EDAT- 2012/05/18 06:00
MHDA- 2014/04/30 06:00
CRDT- 2012/05/18 06:00
PHST- 2012/05/18 06:00 [entrez]
PHST- 2012/05/18 06:00 [pubmed]
PHST- 2014/04/30 06:00 [medline]
AID - 10.1111/j.1365-2850.2012.01921.x [doi]
PST - ppublish
SO  - J Psychiatr Ment Health Nurs. 2012 Dec;19(10):950-7. doi:
      10.1111/j.1365-2850.2012.01921.x. Epub 2012 May 17.


PMID- 22591024
OWN - NLM
STAT- MEDLINE
DCOM- 20140407
LR  - 20211021
IS  - 1740-8709 (Electronic)
IS  - 1740-8695 (Linking)
VI  - 9
IP  - 4
DP  - 2013 Oct
TI  - Nutrition research in rural communities: application of ethical principles.
PG  - 435-51
LID - 10.1111/j.1740-8709.2012.00414.x [doi]
AB  - This narrative review focuses on ethics related to nutrition-specific
      community-based research, within the framework of science for society, and
      focusing on the rights and well-being of fieldworkers and research participants. 
      In addition to generally accepted conditions of scientific validity, such as
      adequate sample size, unbiased measurement outcome and suitable study population,
      research needs to be appropriate and feasible within the local context.
      Communities' suspicions about research can be overcome through community
      participation and clear dialogue. Recruitment of fieldworkers and research
      participants should be transparent and guided by project-specific selection
      criteria. Fieldworkers need to be adequately trained, their daily schedules and
      remuneration must be realistic, and their inputs to the study must be recognized.
      Fieldworkers may be negatively affected emotionally, financially and physically. 
      Benefits to research participants may include physical and psychological
      benefits, minimal economic benefit, and health education; while risks may be of a
      physical, psychological, social, or economic nature. Targeting individuals in
      high-risk groups may result in social stigmatization. The time burden to the
      research participant can be minimized by careful attention to study procedures
      and questionnaire design. Potential benefits to the community, fieldworkers and
      research participants and anticipated knowledge to be gained should outweigh and 
      justify the potential risks. Researchers should have an exit strategy for study
      participants. For effective dissemination of results to individual research
      participants, the host community and nutrition community, the language, format
      and level of presentation need to be appropriate for the target audience.
CI  - (c) 2012 John Wiley & Sons Ltd.
FAU - Faber, Mieke
AU  - Faber M
AD  - Nutritional Intervention Research Unit, Medical Research Council, Tygerberg,
      South Africa Centre of Excellence for Nutrition, North-West University,
      Potchefstroom, South Africa.
FAU - Kruger, H Salome
AU  - Kruger HS
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120516
PL  - England
TA  - Matern Child Nutr
JT  - Maternal & child nutrition
JID - 101201025
SB  - IM
MH  - Community-Based Participatory Research/ethics/*methods
MH  - Developing Countries
MH  - *Health Promotion/ethics
MH  - Human Experimentation/ethics
MH  - Human Rights
MH  - Humans
MH  - Nutritional Sciences/ethics/*methods
MH  - *Rural Health
PMC - PMC6860643
OTO - NOTNLM
OT  - children
OT  - community
OT  - community-based
OT  - ethics
OT  - nutritional interventions
OT  - public health
OT  - research methodology
EDAT- 2012/05/18 06:00
MHDA- 2014/04/08 06:00
CRDT- 2012/05/18 06:00
PHST- 2012/05/18 06:00 [entrez]
PHST- 2012/05/18 06:00 [pubmed]
PHST- 2014/04/08 06:00 [medline]
AID - 10.1111/j.1740-8709.2012.00414.x [doi]
PST - ppublish
SO  - Matern Child Nutr. 2013 Oct;9(4):435-51. doi: 10.1111/j.1740-8709.2012.00414.x.
      Epub 2012 May 16.


PMID- 22590478
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130110
LR  - 20211021
IS  - 1756-2864 (Electronic)
IS  - 1756-2856 (Linking)
VI  - 5
IP  - 3
DP  - 2012 May
TI  - Ethical challenges in paediatric clinical trials in multiple sclerosis.
PG  - 139-46
LID - 10.1177/1756285612437360 [doi]
AB  - Children and adolescents with multiple sclerosis (MS) are reported to show high
      rates of relapse early in the course of the disease as well as cognitive
      deterioration over time. Immunomodulatory therapies developed for adult MS
      patients are currently the standard first-line agents for most paediatric MS
      patients. Available data indicate that the three interferon-beta preparations and
      glatiramer acetate are safe and well tolerated in children and adolescents with
      MS, and provide preliminary indications of efficacy in terms of relapse rate
      reduction. However, these treatments are only partly effective and their routes
      of administration can be bothersome, particularly for children. Emerging
      therapies for MS offer promise for improved disease control and long-term
      clinical outcome, with the advantage of an oral administration for some of them. 
      The future approval of these new medications requires clinical trial
      consideration of such therapies in the paediatric population. Many of these new
      agents carry a higher risk for serious adverse events with increased toxicity and
      still undefined long-term side effects. There are ethical issues as well as
      issues related to feasibility that must be borne in mind when planning
      investigation trials for new pharmacological agents in the paediatric population,
      including immunological maturity, key period of exposure to numerous
      community-acquired infections, neurodevelopmental factors, in addition to
      short-term and long-term age-related toxicities. Furthermore, the lack of a large
      enough paediatric MS population worldwide limits some designs and the feasibility
      of participation in all the studies. Emerging new therapies have the potential to
      optimize the care of both paediatric and adult patients with MS. Future treatment
      trials in children and adolescents with MS will require a multicentre design,
      definition and selection of key outcome measures, and identification of the most 
      promising therapies. Risks versus benefits of each specific treatment should be
      weighed and comprehensively discussed.
FAU - Tenembaum, Silvia N
AU  - Tenembaum SN
AD  - Staff Neurologist, Department of Neurology, National Pediatric Hospital Dr Juan
      P. Garrahan, Billinghurst 850. Buenos Aires, 1174 Argentina.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Ther Adv Neurol Disord
JT  - Therapeutic advances in neurological disorders
JID - 101480242
PMC - PMC3349081
OTO - NOTNLM
OT  - adolescence
OT  - childhood
OT  - clinical trials
OT  - ethics
OT  - immunomodulatory treatment
OT  - immunosuppression
OT  - multiple sclerosis
OT  - new therapies
OT  - recruitment
EDAT- 2012/05/17 06:00
MHDA- 2012/05/17 06:01
CRDT- 2012/05/17 06:00
PHST- 2012/05/17 06:00 [entrez]
PHST- 2012/05/17 06:00 [pubmed]
PHST- 2012/05/17 06:01 [medline]
AID - 10.1177/1756285612437360 [doi]
AID - 10.1177_1756285612437360 [pii]
PST - ppublish
SO  - Ther Adv Neurol Disord. 2012 May;5(3):139-46. doi: 10.1177/1756285612437360.


PMID- 22589322
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20220129
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 264
IP  - 1
DP  - 2012 Jul
TI  - Dual inversion-recovery mr imaging sequence for reduced blood signal on late
      gadolinium-enhanced images of myocardial scar.
PG  - 242-9
LID - 10.1148/radiol.12112004 [doi]
AB  - PURPOSE: To investigate whether a dual inversion-recovery (IR) prepulse improves 
      scar-to-blood contrast and expert confidence and consistency at late
      gadolinium-enhanced magnetic resonance (MR) imaging of myocardial scar compared
      with the standard IR technique at 3.0 T. MATERIALS AND METHODS: The study was
      approved by the local ethics committee, and all patients provided written
      informed consent. Twelve men (mean age+/-standard deviation, 63 years+/-8) with
      known myocardial scar underwent MR imaging 10, 20, and 30 minutes after
      administration of 0.2 mmol/kg gadobutrol with a standard and dual IR sequence.
      Contrast-to-noise ratios (CNRs) were measured by using region-of-interest
      analysis, and data were compared with the analysis of variance test. Two experts 
      measured scar size and transmurality, and data were compared with the Student t
      test and Bland-Altman test. Experts assigned confidence scores for scar detection
      and transmurality, which were compared with a Wilcoxon matched-pairs signed rank 
      test. RESULTS: Patient data showed improved scar-to-blood CNR for the dual IR
      technique compared with the standard IR technique at all time points (P<.05). For
      images obtained 20 minutes after contrast material administration, the dual IR
      sequence provided higher confidence scores for scar detection and transmurality
      assessment (P<.05) and resulted in more consistent assessment of scar size and
      transmurality between readers compared with the IR sequence (P<.05). CONCLUSION: 
      In this preliminary patient study, the dual IR prepulse improved contrast, scar
      visualization, and expert confidence and reduced expert differences in
      transmurality and scar size assessment compared with the standard IR technique.
CI  - (c) RSNA, 2012.
FAU - Peel, Sarah A
AU  - Peel SA
AD  - Division of Imaging Sciences and Biomedical Engineering, King's College London,
      Rayne Institute, 4th Floor Lambeth Wing, St Thomas' Hospital, Westminster Bridge 
      Rd, SE1 7EH London, England. sarah.peel@kcl.ac.uk
FAU - Morton, Geraint
AU  - Morton G
FAU - Chiribiri, Amedeo
AU  - Chiribiri A
FAU - Schuster, Andreas
AU  - Schuster A
FAU - Nagel, Eike
AU  - Nagel E
FAU - Botnar, Rene M
AU  - Botnar RM
LA  - eng
GR  - RG/12/1/29262/BHF_/British Heart Foundation/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120515
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 1BJ477IO2L (gadobutrol)
SB  - IM
MH  - Analysis of Variance
MH  - Cicatrix/*pathology
MH  - Contrast Media
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*pathology
MH  - Organometallic Compounds
MH  - Software
MH  - Statistics, Nonparametric
EDAT- 2012/05/17 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/05/17 06:00
PHST- 2012/05/17 06:00 [entrez]
PHST- 2012/05/17 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
AID - radiol.12112004 [pii]
AID - 10.1148/radiol.12112004 [doi]
PST - ppublish
SO  - Radiology. 2012 Jul;264(1):242-9. doi: 10.1148/radiol.12112004. Epub 2012 May 15.


PMID- 22588682
OWN - NLM
STAT- MEDLINE
DCOM- 20121221
LR  - 20211021
IS  - 1573-3645 (Electronic)
IS  - 1041-3545 (Linking)
VI  - 33
IP  - 3
DP  - 2012 Sep
TI  - 'Murder by milligrams': enhancement technologies and therapeutic zeal in Timothy 
      Findley's Headhunter".
PG  - 161-73
LID - 10.1007/s10912-012-9178-4 [doi]
AB  - In his 1993 novel Headhunter, Canadian author Timothy Findley describes the
      tendency of some medical practitioners to put scientific interests above the
      therapeutic needs of the individual. As the book's title and name of the main
      character Dr. Kurtz attest, Findley reflects the colonialist teleology found in
      Heart of Darkness as an analogue for the therapeutic zeal shown by many of the
      physicians in Headhunter. In the novel, such zeal is especially problematic when 
      it is combined with so-called enhancement technologies, since enhancement, like
      colonialism, can be based in the prejudices of the practitioner and/or the
      dominant society, rather than in the needs of the patient. To counter therapeutic
      zeal, Findley, like Conrad, proposes an ethics of restraint in which the
      practitioner's empathy outweighs his or her desire for scientific discovery.
FAU - Reed, Sabrina
AU  - Reed S
AD  - Faculty of Arts, Mount Royal University, 4825 Mount Royal Gate S.W., Calgary, AB,
      Canada T3E 6K6. sreed@mtroyal.ca
LA  - eng
PT  - Historical Article
PT  - Journal Article
PL  - United States
TA  - J Med Humanit
JT  - The Journal of medical humanities
JID - 8917478
SB  - IM
MH  - Books/*history
MH  - Ethics, Medical/*history
MH  - History, 20th Century
MH  - Humans
MH  - *Medicine in the Arts
MH  - Practice Patterns, Physicians'/*history
MH  - Schizophrenia/history
MH  - *Writing
EDAT- 2012/05/17 06:00
MHDA- 2012/12/22 06:00
CRDT- 2012/05/17 06:00
PHST- 2012/05/17 06:00 [entrez]
PHST- 2012/05/17 06:00 [pubmed]
PHST- 2012/12/22 06:00 [medline]
AID - 10.1007/s10912-012-9178-4 [doi]
PST - ppublish
SO  - J Med Humanit. 2012 Sep;33(3):161-73. doi: 10.1007/s10912-012-9178-4.


PMID- 22588677
OWN - NLM
STAT- MEDLINE
DCOM- 20140122
LR  - 20211021
IS  - 1471-5546 (Electronic)
IS  - 1353-3452 (Linking)
VI  - 19
IP  - 3
DP  - 2013 Sep
TI  - Gaming, texting, learning? Teaching engineering ethics through students' lived
      experiences with technology.
PG  - 1375-93
LID - 10.1007/s11948-012-9368-5 [doi]
AB  - This paper examines how young peoples' lived experiences with personal
      technologies can be used to teach engineering ethics in a way which facilitates
      greater engagement with the subject. Engineering ethics can be challenging to
      teach: as a form of practical ethics, it is framed around future workplace
      experience in a professional setting which students are assumed to have no prior 
      experience of. Yet the current generations of engineering students, who have been
      described as 'digital natives', do however have immersive personal experience
      with digital technologies; and experiential learning theory describes how
      students learn ethics more successfully when they can draw on personal experience
      which give context and meaning to abstract theories. This paper reviews current
      teaching practices in engineering ethics; and examines young people's engagement 
      with technologies including cell phones, social networking sites, digital music
      and computer games to identify social and ethical elements of these practices
      which have relevance for the engineering ethics curricula. From this analysis
      three case studies are developed to illustrate how facets of the use of these
      technologies can be drawn on to teach topics including group work and
      communication; risk and safety; and engineering as social experimentation. Means 
      for bridging personal experience and professional ethics when teaching these
      cases are discussed. The paper contributes to research and curriculum development
      in engineering ethics education, and to wider education research about methods of
      teaching 'the net generation'.
FAU - Voss, Georgina
AU  - Voss G
AD  - Faculty of Arts, University of Brighton, UK. g.s.voss@brighton.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20120516
PL  - England
TA  - Sci Eng Ethics
JT  - Science and engineering ethics
JID - 9516228
SB  - IM
MH  - Cell Phone/ethics
MH  - *Curriculum
MH  - Engineering/*education/ethics
MH  - Ethics, Professional/*education
MH  - Ethics, Research/*education
MH  - Humans
MH  - Internet/ethics
MH  - Music
MH  - Social Networking
MH  - Students
MH  - Teaching/*methods
MH  - Technology/*ethics
MH  - Text Messaging/ethics
MH  - Video Games/ethics
EDAT- 2012/05/17 06:00
MHDA- 2014/01/23 06:00
CRDT- 2012/05/17 06:00
PHST- 2012/01/24 00:00 [received]
PHST- 2012/04/29 00:00 [accepted]
PHST- 2012/05/17 06:00 [entrez]
PHST- 2012/05/17 06:00 [pubmed]
PHST- 2014/01/23 06:00 [medline]
AID - 10.1007/s11948-012-9368-5 [doi]
PST - ppublish
SO  - Sci Eng Ethics. 2013 Sep;19(3):1375-93. doi: 10.1007/s11948-012-9368-5. Epub 2012
      May 16.


PMID- 22586939
OWN - NLM
STAT- MEDLINE
DCOM- 20120717
LR  - 20120516
IS  - 1341-8963 (Print)
IS  - 1341-8963 (Linking)
VI  - 47
IP  - 1
DP  - 2012 Feb
TI  - [Understanding a new conception of addiction in current clinical practices].
PG  - 13-23
AB  - This paper described the historical process that the conception of "addiction"
      and "dependence" have been formed and changed. Before, the "addiction" was a
      prejudiced word used when people contempt an individual with compulsive drinking 
      or taking psychoactive drugs, and this word implied moralistic and ethical faults
      of the individual. After that, this word describing an individual without control
      of drinking was taken place by the "dependence." This is the neutral and medical 
      conception, defined by presence of tolerance and withdrawal symptoms, although it
      was based on the "alcoholism." which originated in the citizen movement in 1930s 
      in U.S. Recently some professionals have preferred to use the "addiction" when
      describing an individual losing control of deviated, impulsive, and repetitive
      behavior including pathological gambling and compulsive buying. These behaviors
      have been discriminated form substance dependence, while clinically applied to
      analogical treatment to substance dependence. However, the DSM-5 draft which the 
      American Psychiatric Association has published as a draft of new diagnostic
      criteria for mental disorders has classified both of substance dependence and
      addictive behavior into the same category, and has removed the word "dependence" 
      in the description. In this paper, we looked back on historical conflicts between
      the two words of "dependence" and "addiction," and discussed the clinical
      meanings and problems of these words.
FAU - Matsumoto, Toshihiko
AU  - Matsumoto T
AD  - Department of Drug Dependence Research/Center for Suicide Prevention, National
      Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1
      Ogawahigashi-cho, Kodaira, Tokyo 187-8553, Japan. tmatsu@ncnp.go.jp
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Nihon Arukoru Yakubutsu Igakkai Zasshi
JT  - Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies &
      drug dependence
JID - 9612304
SB  - IM
MH  - *Behavior, Addictive
MH  - Humans
MH  - *Substance-Related Disorders
EDAT- 2012/05/17 06:00
MHDA- 2012/07/18 06:00
CRDT- 2012/05/17 06:00
PHST- 2012/05/17 06:00 [entrez]
PHST- 2012/05/17 06:00 [pubmed]
PHST- 2012/07/18 06:00 [medline]
PST - ppublish
SO  - Nihon Arukoru Yakubutsu Igakkai Zasshi. 2012 Feb;47(1):13-23.


PMID- 22586841
OWN - NLM
STAT- MEDLINE
DCOM- 20120612
LR  - 20211021
IS  - 0963-6625 (Print)
IS  - 0963-6625 (Linking)
VI  - 21
IP  - 2
DP  - 2012 Feb
TI  - Synthetic biology in the view of European public funding organisations.
PG  - 149-62
AB  - We analysed the decisions of major European public funding organisations to fund 
      or not to fund synthetic biology (SB) and related ethical, legal and social
      implication (ELSI) studies. We investigated the reaction of public organisations 
      in six countries (Austria, France, Germany, the Netherlands, Switzerland and the 
      U.K.) towards SB that may influence SB's further development in Europe. We
      examined R&D and ELSI communities and their particular funding situation. Our
      results show that the funding situation for SB varies considerably among the
      analysed countries, with the U.K. as the only country with an established funding
      scheme for R&D and ELSI that successfully integrates these research communities. 
      Elsewhere, we determined a general lack of funding (France), difficulties in
      funding ELSI work (Switzerland), lack of an R&D community (Austria), too small
      ELSI communities (France, Switzerland, Netherlands), or difficulties in linking
      existing communities with available funding sources (Germany), partly due to an
      unclear SB definition.
FAU - Pei, Lei
AU  - Pei L
AD  - Ansbach University of Applied Sciences, Germany.
FAU - Gaisser, Sibylle
AU  - Gaisser S
FAU - Schmidt, Markus
AU  - Schmidt M
LA  - eng
GR  - I 215/FWF_/Austrian Science Fund FWF/Austria
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Public Underst Sci
JT  - Public understanding of science (Bristol, England)
JID - 9306503
MH  - Academies and Institutes/economics
MH  - Europe
MH  - Financing, Government/economics/legislation & jurisprudence/*organization &
      administration
MH  - Humans
MH  - Policy
MH  - Research/economics
MH  - Synthetic Biology/*economics/ethics/legislation & jurisprudence
PMC - PMC3311122
EDAT- 2012/05/17 06:00
MHDA- 2012/06/13 06:00
CRDT- 2012/05/17 06:00
PHST- 2012/05/17 06:00 [entrez]
PHST- 2012/05/17 06:00 [pubmed]
PHST- 2012/06/13 06:00 [medline]
AID - 10.1177/0963662510393624 [doi]
PST - ppublish
SO  - Public Underst Sci. 2012 Feb;21(2):149-62. doi: 10.1177/0963662510393624.


PMID- 22586288
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 3
DP  - 2012
TI  - Observational study on factors related to health-promoting community activity
      development in primary care (frAC Project): a study protocol.
LID - 10.1136/bmjopen-2012-001287 [doi]
LID - e001287 [pii]
AB  - INTRODUCTION: According to Spanish health regulations, primary care professionals
      have the responsibility to carry out health-promoting community activities (CAs).
      However, in practice, their implementation is not as widespread as it should be. 
      The aims of this study were to identify factors within the team, the community
      and the professionals that influence the development of these activities and to
      describe the community interventions in progress. METHODS AND ANALYSIS: This
      study is an observational analytical retrospective study. The information will be
      collected from five Spanish regions: Catalonia, Madrid, the Balearic Islands,
      Navarra and Aragon. The authors will contact primary care teams (PCTs) and
      identify the CAs from the previous year. The research team will conduct a peer
      review whether the inclusion criteria are met. In the health centres where CAs
      are implemented, the authors will select professionals carrying them out and
      randomly select an identical number of professionals not doing these activities. 
      In the centres where no CA is implemented, three professionals will be randomly
      selected. The selected professionals will complete the questionnaires for
      individual-level variables. Information about the registered population and the
      PCTs will be collected through questionnaires and secondary sources. OUTCOMES:
      Variables will be collected from the community, the PCTs, the individual
      professionals and CAs. ANALYSIS: A descriptive analysis of all the variables will
      be carried out, along with a bivariate and a logistic regression analysis, with
      CAs being the primary outcome. ETHICS AND DISSEMINATION: This study has been
      approved by the Research Ethics Committee of the Jordi Gol y Gurina Foundation in
      Barcelona and area 11 in Madrid. The questionnaire distributed to the
      professionals will be anonymous.
FAU - March, Sebastia
AU  - March S
AD  - Primary Care Research Unit of Mallorca, Baleares Health Services-IbSalut, Palma
      de Mallorca, Spain.
FAU - Ripoll, Joana
AU  - Ripoll J
FAU - Ruiz-Gimenez, Juan Luis
AU  - Ruiz-Gimenez JL
FAU - Montaner Gomis, Isabel
AU  - Montaner Gomis I
FAU - Benede Azagra, Carmen Belen
AU  - Benede Azagra CB
FAU - Elizalde Soto, Lazaro
AU  - Elizalde Soto L
FAU - Vidal, M Clara
AU  - Vidal MC
FAU - Bauza Amengual, M de Lluc
AU  - Bauza Amengual Mde L
FAU - Planas Juan, Trinidad
AU  - Planas Juan T
FAU - Maria Perez Mariano, Damiana
AU  - Maria Perez Mariano D
FAU - Llull Sarralde, Micaela
AU  - Llull Sarralde M
FAU - Bajo Vinas, Rosa
AU  - Bajo Vinas R
FAU - Jordan Martin, Matilde
AU  - Jordan Martin M
FAU - Solano Villarubia, Carmen
AU  - Solano Villarubia C
FAU - Rodriguez Bajo, Maria
AU  - Rodriguez Bajo M
FAU - Cordoba Victoria, Manuela
AU  - Cordoba Victoria M
FAU - Badia Capdevila, Marta
AU  - Badia Capdevila M
FAU - Serrano Ferrandez, Elena
AU  - Serrano Ferrandez E
FAU - Bosom Diumenjo, Maria
AU  - Bosom Diumenjo M
FAU - Zabaleta Del Olmo, Nieves
AU  - Zabaleta Del Olmo N
FAU - Bolivar-Ribas, Bonaventura
AU  - Bolivar-Ribas B
FAU - Antonanzas Lombarte, Angel
AU  - Antonanzas Lombarte A
FAU - Bregel Cotaina, Samantha
AU  - Bregel Cotaina S
FAU - Calvo Tocado, Ana
AU  - Calvo Tocado A
FAU - Olivan Blazquez, Barbara
AU  - Olivan Blazquez B
FAU - Magallon Botaya, Rosa
AU  - Magallon Botaya R
FAU - Marin Palacios, Pilar
AU  - Marin Palacios P
FAU - Echauri Ozcoidi, Margarita
AU  - Echauri Ozcoidi M
FAU - Perez-Jarauta, M Jose
AU  - Perez-Jarauta MJ
FAU - Ramos, Maria
AU  - Ramos M
LA  - eng
PT  - Journal Article
DEP - 20120514
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3358617
EDAT- 2012/05/16 06:00
MHDA- 2012/05/16 06:01
CRDT- 2012/05/16 06:00
PHST- 2012/05/16 06:00 [entrez]
PHST- 2012/05/16 06:00 [pubmed]
PHST- 2012/05/16 06:01 [medline]
AID - bmjopen-2012-001287 [pii]
AID - 10.1136/bmjopen-2012-001287 [doi]
PST - epublish
SO  - BMJ Open. 2012 May 14;2(3). pii: bmjopen-2012-001287. doi:
      10.1136/bmjopen-2012-001287. Print 2012.


PMID- 22586283
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 2
IP  - 3
DP  - 2012
TI  - Efficacy and tolerability of a beta-1 selective beta blocker, bisoprolol, as a
      first-line antihypertensive in Indian patients diagnosed with essential
      hypertension (BRIGHT): an open-label, multicentric observational study.
LID - 10.1136/bmjopen-2011-000683 [doi]
LID - e000683 [pii]
AB  - OBJECTIVES: This study was aimed to evaluate the efficacy and tolerability of
      bisoprolol, in Indian patients diagnosed with stage I essential hypertension as
      first-line drug. DESIGN: This was an open-label, phase IV, multicentric
      prospective study. SETTINGS: 239 outpatient centres across India. PARTICIPANTS:
      After ethical approval, patients who were willing to sign informed consent, who
      are newly diagnosed with JNC VII stage I essential hypertension (systolic blood
      pressure 140-159 mm Hg or diastolic blood pressure 90-99 mm Hg) and who are
      prescribed bisoprolol were enrolled in the study. Patients with significant organ
      disease or complications, women of childbearing age refusing reliable
      contraceptive method, patients with known contraindications (like symptomatic
      bradycardia, significant atrioventricular blockade, sick sinus syndrome) and
      patients with known hypersensitivity reactions to bisoprolol and unwilling
      patients were excluded. PRIMARY AND SECONDARY OUTCOMES MEASURES: The primary
      outcome measure was percentage of patients achieving blood pressure (BP)
      </=140/90 mm Hg at the end of 12 weeks, while multiple secondary outcome measures
      were assessed. RESULTS: Of 2418 patients screened, 2161 patients were recruited
      (66.64% men, mean age 51.7+/-9.8 years, smokers 19.19%) and 2131 (96.44%)
      patients achieved BP control. There was significant reduction in systolic blood
      pressure (-25.29; SD: 13.22 mm Hg), diastolic blood pressure (-14.14; SD: 7.67 mm
      Hg) and heart rate (-12/min; SD: 6.15) compared with baseline (all p values
      <0.05). The median dose of bisoprolol and average period required for the
      response were 5 mg/day and 33 days, respectively. Bisoprolol was found to be well
      tolerated in the patients up to 10 mg/day. A total of 1.9% patients showed
      adverse events, which were mild to moderate in severity without any severe
      adverse event. None required treatment withdrawal. CONCLUSION: Bisoprolol is an
      effective and safe option to control BP. Thus, it can be used as one of the
      first-line antihypertensive in Indian patients.
FAU - Channaraya, V
AU  - Channaraya V
AD  - KIMS Hospital, Bengaluru, India.
FAU - Marya, R K
AU  - Marya RK
FAU - Somasundaram, M
AU  - Somasundaram M
FAU - Mitra, Debashish
AU  - Mitra D
FAU - Tibrewala, K D
AU  - Tibrewala KD
CN  - BRIGHT investigators
LA  - eng
PT  - Journal Article
DEP - 20120514
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
PMC - PMC3358619
EDAT- 2012/05/16 06:00
MHDA- 2012/05/16 06:01
CRDT- 2012/05/16 06:00
PHST- 2012/05/16 06:00 [entrez]
PHST- 2012/05/16 06:00 [pubmed]
PHST- 2012/05/16 06:01 [medline]
AID - bmjopen-2011-000683 [pii]
AID - 10.1136/bmjopen-2011-000683 [doi]
PST - epublish
SO  - BMJ Open. 2012 May 14;2(3). pii: bmjopen-2011-000683. doi:
      10.1136/bmjopen-2011-000683. Print 2012.


PMID- 22586209
OWN - NLM
STAT- MEDLINE
DCOM- 20120827
LR  - 20220408
IS  - 1471-8391 (Electronic)
IS  - 0007-1420 (Linking)
VI  - 102
DP  - 2012 Jun
TI  - Medical, statistical, ethical and human rights considerations in the assessment
      of age in children and young people subject to immigration control.
PG  - 17-42
LID - 10.1093/bmb/lds014 [doi]
AB  - BACKGROUND: Unprecedented changes in both the scale and the complexity of
      international migration have led to international concern and controversy over
      the assessment of age in children and young people subject to immigration control
      or seeking asylum who say they are children yet have no documents to prove their 
      stated age. SOURCES OF DATA: The article reviews the existing evidence on the
      reliability of medical and non-medical techniques for the assessment of
      chronological age. AREAS OF AGREEMENT: There is evidence that radiography
      (X-rays) of bones and teeth, which is increasingly relied upon by immigration
      authorities, is imprecise, unethical and potentially unlawful, and should not be 
      used for age assessment. AREAS OF CONTROVERSY: Medical techniques including
      X-rays continue to be relied upon in the absence of an alternative approach
      resulting in legal challenges and uncertainty for children and young people.
      AREAS TIMELY FOR DEVELOPING RESEARCH: Further work is needed to establish a
      process for age assessment based on a 'holistic' multi-disciplinary approach
      which focuses not on chronological age exclusively but rather on the needs of
      children and young people subject to immigration control.
FAU - Aynsley-Green, A
AU  - Aynsley-Green A
AD  - University College London, UK. al@aynsley-green.com
FAU - Cole, T J
AU  - Cole TJ
FAU - Crawley, H
AU  - Crawley H
FAU - Lessof, N
AU  - Lessof N
FAU - Boag, L R
AU  - Boag LR
FAU - Wallace, R M M
AU  - Wallace RM
LA  - eng
GR  - G0400546/MRC_/Medical Research Council/United Kingdom
GR  - G9827821/MRC_/Medical Research Council/United Kingdom
GR  - MR/J004839/1/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Review
DEP - 20120514
PL  - England
TA  - Br Med Bull
JT  - British medical bulletin
JID - 0376542
SB  - IM
MH  - Age Determination by Skeleton/*ethics/methods
MH  - Age Determination by Teeth/methods
MH  - Age Factors
MH  - Anthropometry/methods
MH  - Bioethical Issues
MH  - Child
MH  - Child Welfare/*ethics/statistics & numerical data
MH  - *Emigration and Immigration
MH  - Europe
MH  - *Human Rights
MH  - Humans
MH  - Refugees
EDAT- 2012/05/16 06:00
MHDA- 2012/08/28 06:00
CRDT- 2012/05/16 06:00
PHST- 2012/05/16 06:00 [entrez]
PHST- 2012/05/16 06:00 [pubmed]
PHST- 2012/08/28 06:00 [medline]
AID - lds014 [pii]
AID - 10.1093/bmb/lds014 [doi]
PST - ppublish
SO  - Br Med Bull. 2012 Jun;102:17-42. doi: 10.1093/bmb/lds014. Epub 2012 May 14.


PMID- 22586013
OWN - NLM
STAT- MEDLINE
DCOM- 20120716
LR  - 20130625
IS  - 1539-3704 (Electronic)
IS  - 0003-4819 (Linking)
VI  - 156
IP  - 10
DP  - 2012 May 15
TI  - A certain gift, and a question of ethics.
PG  - 750-1
LID - 10.7326/0003-4819-156-10-201205150-00017 [doi]
FAU - Bhardwaj, Shilpa
AU  - Bhardwaj S
AD  - Griffin Hospital and Yale University, Derby, CT 06418, USA.
      bhardwaj.shilpa@gmail.com
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Intern Med
JT  - Annals of internal medicine
JID - 0372351
SB  - IM
MH  - Gift Giving/*ethics
MH  - Hospitals, State
MH  - Humans
MH  - India
MH  - Internship and Residency/*ethics
MH  - Physician-Patient Relations/*ethics
MH  - Poverty
MH  - Rural Population
EDAT- 2012/05/16 06:00
MHDA- 2012/07/17 06:00
CRDT- 2012/05/16 06:00
PHST- 2012/05/16 06:00 [entrez]
PHST- 2012/05/16 06:00 [pubmed]
PHST- 2012/07/17 06:00 [medline]
AID - 156/10/750 [pii]
AID - 10.7326/0003-4819-156-10-201205150-00017 [doi]
PST - ppublish
SO  - Ann Intern Med. 2012 May 15;156(10):750-1. doi:
      10.7326/0003-4819-156-10-201205150-00017.


PMID- 22586012
OWN - NLM
STAT- MEDLINE
DCOM- 20120716
LR  - 20181201
IS  - 1539-3704 (Electronic)
IS  - 0003-4819 (Linking)
VI  - 156
IP  - 10
DP  - 2012 May 15
TI  - Ethical dilemmas and malfunctions in clinical trials research.
PG  - 746-7
LID - 10.7326/0003-4819-156-10-201205150-00015 [doi]
FAU - Pocock, Stuart J
AU  - Pocock SJ
LA  - eng
PT  - Editorial
PT  - Comment
PL  - United States
TA  - Ann Intern Med
JT  - Annals of internal medicine
JID - 0372351
SB  - IM
CON - Ann Intern Med. 2012 May 15;156(10):673-83. PMID: 22586006
MH  - *Case Management
MH  - Female
MH  - *Hospitalization
MH  - Humans
MH  - Male
MH  - *Patient Education as Topic
MH  - Pulmonary Disease, Chronic Obstructive/*drug therapy
EDAT- 2012/05/16 06:00
MHDA- 2012/07/17 06:00
CRDT- 2012/05/16 06:00
PHST- 2012/05/16 06:00 [entrez]
PHST- 2012/05/16 06:00 [pubmed]
PHST- 2012/07/17 06:00 [medline]
AID - 156/10/746 [pii]
AID - 10.7326/0003-4819-156-10-201205150-00015 [doi]
PST - ppublish
SO  - Ann Intern Med. 2012 May 15;156(10):746-7. doi:
      10.7326/0003-4819-156-10-201205150-00015.


PMID- 22585627
OWN - NLM
STAT- MEDLINE
DCOM- 20120911
LR  - 20191210
IS  - 1526-4564 (Electronic)
IS  - 1526-4564 (Linking)
VI  - 30
IP  - 3
DP  - 2012 Jun
TI  - Safety, efficacy, and complexities in ART practice: physician commentary.
PG  - 167-72
LID - 10.1055/s-0032-1311518 [doi]
AB  - There are few patient care processes for which a team approach is more important 
      than for assisted reproduction. Close, continuous communication is required at
      many levels among physicians, nursing staff, therapists, the various
      laboratories, and patients. Quality of care is associated with the reduction of
      medical errors through processes of risk management, mechanisms to allow the safe
      evolution of assisted reproductive technology care within the clinic, and how
      clinics ethically communicate with team members and with patients through
      informed consent and direct and honest interaction.
CI  - Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
FAU - Gibbons, William F
AU  - Gibbons WF
AD  - Division of Reproductive Endocrinology and Infertility, Department of Obstetrics 
      and Gynecology, Baylor College of Medicine, 1709 Dryden Rd, Ste 1141, Houston, TX
      77030, USA. gibbons@bcm.edu
LA  - eng
PT  - Journal Article
DEP - 20120514
PL  - United States
TA  - Semin Reprod Med
JT  - Seminars in reproductive medicine
JID - 100909394
SB  - IM
MH  - Communication
MH  - Cooperative Behavior
MH  - Humans
MH  - Informed Consent
MH  - Laboratories/*organization & administration/standards
MH  - Medical Errors/*prevention & control
MH  - Process Assessment, Health Care
MH  - *Reproductive Techniques, Assisted
MH  - *Risk Management
EDAT- 2012/05/16 06:00
MHDA- 2012/09/12 06:00
CRDT- 2012/05/16 06:00
PHST- 2012/05/16 06:00 [entrez]
PHST- 2012/05/16 06:00 [pubmed]
PHST- 2012/09/12 06:00 [medline]
AID - 10.1055/s-0032-1311518 [doi]
PST - ppublish
SO  - Semin Reprod Med. 2012 Jun;30(3):167-72. doi: 10.1055/s-0032-1311518. Epub 2012
      May 14.


PMID- 22585268
OWN - NLM
STAT- MEDLINE
DCOM- 20120705
LR  - 20151119
IS  - 0966-0461 (Print)
IS  - 0966-0461 (Linking)
VI  - 21
IP  - 9
DP  - 2012 May 10-23
TI  - What are pre-registration nurses taught about caring for children?
PG  - 544-8
AB  - Nurse education curricula have to be continually reviewed to ensure that content 
      remains applicable to contemporary healthcare developments. In this article, the 
      authors report the findings of a research study that investigated the children's 
      nursing component taught in all non-children's BSc Nursing degree programmes in
      Irish colleges. The aim of the study was to identify how European Union
      directives and national curriculum guidelines are interpreted in colleges, and to
      clarify the preparation that non-children's pre-registration nursing students
      receive with respect to caring for children. The authors explored aspects related
      to children's nursing in all non-children's undergraduate pre-registration
      programmes, including curriculum content and its delivery, assessments and
      practice experiences. Data were collected by a specifically designed
      questionnaire based on the Requirements and Standards for Nurse Education
      Programmes (An Bord Altranais, 2005a; b). A university ethics committee provided 
      ethical approval. The response rate was 54% (n=7), and data were analysed using
      SPSS 16 and content analysis. The authors' findings illustrated that the
      requirements and standards of all nursing programmes are interpreted in a variety
      of ways regarding children's nursing. Nationally, nursing content related to
      children needs to be reviewed in all nursing programmes to ensure consistency
      among providers. Healthcare requirements for children and families need to be
      heightened within curricula for all disciplines.
FAU - Nicholl, Honor
AU  - Nicholl H
AD  - Children's Nursing, Trinity College Dublin, Ireland.
FAU - Begley, Thelma
AU  - Begley T
FAU - Murphy, Maryanne
AU  - Murphy M
FAU - Hollywood, Eleanor
AU  - Hollywood E
FAU - King, Carole
AU  - King C
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Nurs
JT  - British journal of nursing (Mark Allen Publishing)
JID - 9212059
MH  - Child
MH  - Clinical Competence
MH  - Curriculum
MH  - Education, Nursing/*organization & administration
MH  - Guidelines as Topic
MH  - Humans
MH  - *Patient Admission
MH  - Surveys and Questionnaires
EDAT- 2012/05/16 06:00
MHDA- 2012/07/06 06:00
CRDT- 2012/05/16 06:00
PHST- 2012/05/16 06:00 [entrez]
PHST- 2012/05/16 06:00 [pubmed]
PHST- 2012/07/06 06:00 [medline]
AID - 10.12968/bjon.2012.21.9.544 [doi]
PST - ppublish
SO  - Br J Nurs. 2012 May 10-23;21(9):544-8. doi: 10.12968/bjon.2012.21.9.544.


PMID- 22584771
OWN - NLM
STAT- MEDLINE
DCOM- 20121001
LR  - 20130821
VI  - 16
IP  - 2
DP  - 2012 Apr
TI  - Correlation among the Visual Gait Assessment Scale, Edinburgh Visual Gait Scale
      and Observational Gait Scale in children with spastic diplegic cerebral palsy.
PG  - 134-40
LID - S1413-35552012000200009 [pii]
AB  - BACKGROUND: Gait disorders are very common in children with spastic diplegia
      cerebral palsy (CP). In order to improve the CP children's gait and to quantify
      the outcomes of this intervention it becomes essential to perform an instrumented
      analysis before and after the intervention. OBJECTIVES: To analyze the
      correlation among the Edinburgh Visual Gait Scale (EVGS), the Visual Gait
      Assessment Scale (VGAS) and the Observational Gait Scale (OGS). METHODS: Cross
      sectional study aiming to analyze the gait of 8 children with spastic diplegia CP
      with level I or II in the Gross Motor Function Classification System (GMFCS)
      through the EVGS, VGAS and OGS scales performed by 3 examiners. This study was
      approved by the Research Ethics Committee of the Universidade Estadual de
      Campinas (UNICAMP). Weighted Kappa scores were used to analyze the data
      considering a significance level of 5%. RESULTS: The intra-rater analyses showed 
      a moderate to excellent agreement (k=0.41, 1.00) among the methods of the
      children's classification, being the comparison between VGAS and the EVGS scales 
      presented the highest level of agreement, while the OGS scale presented a
      considerable disagreement in comparison with other scales. The inter-rater
      agreement showed to be predominantly high. CONCLUSIONS: The results provide
      evidence that the VGAS and the EVGS scales are more suitable for children's
      spastic diplegia CP gait assessment when compared to OGS.
FAU - Bella, Geruza P
AU  - Bella GP
AD  - Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, Campinas, SP,
      Brazil. geruzaperlatobella@gmail.com
FAU - Rodrigues, Nadia B B
AU  - Rodrigues NB
FAU - Valenciano, Paola J
AU  - Valenciano PJ
FAU - Silva, Luciana M A E
AU  - Silva LM
FAU - Souza, Regina C T
AU  - Souza RC
LA  - eng
LA  - por
PT  - Comparative Study
PT  - Journal Article
PL  - Brazil
TA  - Rev Bras Fisioter
JT  - Revista brasileira de fisioterapia (Sao Carlos (Sao Paulo, Brazil))
JID - 101186153
RN  - Cerebral palsy, spastic, diplegic
SB  - IM
MH  - Cerebral Palsy/*physiopathology
MH  - Child
MH  - Cross-Sectional Studies
MH  - Female
MH  - *Gait
MH  - Humans
MH  - Male
MH  - Observer Variation
MH  - Physical Examination/methods/statistics & numerical data
EDAT- 2012/05/16 06:00
MHDA- 2012/10/02 06:00
CRDT- 2012/05/16 06:00
PHST- 2011/07/01 00:00 [received]
PHST- 2011/12/01 00:00 [accepted]
PHST- 2012/05/16 06:00 [entrez]
PHST- 2012/05/16 06:00 [pubmed]
PHST- 2012/10/02 06:00 [medline]
AID - S1413-35552012000200009 [pii]
PST - ppublish
SO  - Rev Bras Fisioter. 2012 Apr;16(2):134-40.


PMID- 22584743
OWN - NLM
STAT- MEDLINE
DCOM- 20120710
LR  - 20120515
IS  - 0969-0700 (Print)
IS  - 0969-0700 (Linking)
VI  - 21
IP  - 5
DP  - 2012 May
TI  - The use of larval therapy to reduce the bacterial load in chronic wounds.
PG  - 244-53
AB  - OBJECTIVE: To ascertain the effect of larval therapy against bacteria associated 
      with infected chronic wounds, and determine if larvae therapy actively reduces
      the bacterial load in chronic wounds. METHOD: An extended literature review was
      undertaken using online databases: Athens, Medline, EMBASE, British Nursing Index
      and Allied and Complementary Medicine via OV ID and Cumulative Index to Nursing
      and Allied Health. Key terms were searched worldwide from 1950 to 2011. RESULTS: 
      Four themes emerged: Gram-positive and Gram-negative bacteria, MRSA, quorum
      sensing: biofilm consideration and bacterial burden. This suggests larvae
      debridement therapy is differentially effective against both Gram-positive and
      Gram-negative bacterial strains, namely Staphylococcus aureus, Pseudomonas
      aeruginosa and meticillin-resistant Staphylococcus aureus. CONCLUSION: The
      evidence supports the use of antimicrobial properties of larvae therapy against
      the bacteria of infected chronic wounds. DECLARATION OF INTEREST: There were no
      external sources of funding for this literature review. This paper is based on an
      independent study submitted as part of the BSc Health Care Studies, (Tissue
      Viability), University of Nottingham, UK. The authors have no competing or
      financial interest to declare and ethical approval and funding were not required 
      to undertake the study.
FAU - Blueman, D
AU  - Blueman D
AD  - Nottingham University Hospitals, UK. d-blue@hotmail.co.uk
FAU - Bousfield, C
AU  - Bousfield C
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Wound Care
JT  - Journal of wound care
JID - 9417080
MH  - Animals
MH  - Biofilms
MH  - Chronic Disease
MH  - Gram-Negative Bacterial Infections/therapy
MH  - Gram-Positive Bacterial Infections/therapy
MH  - Humans
MH  - *Larva/physiology
MH  - Methicillin-Resistant Staphylococcus aureus
MH  - Staphylococcal Infections/therapy
MH  - Wound Infection/*microbiology
EDAT- 2012/05/16 06:00
MHDA- 2012/07/11 06:00
CRDT- 2012/05/16 06:00
PHST- 2012/05/16 06:00 [entrez]
PHST- 2012/05/16 06:00 [pubmed]
PHST- 2012/07/11 06:00 [medline]
AID - 10.12968/jowc.2012.21.5.244 [doi]
PST - ppublish
SO  - J Wound Care. 2012 May;21(5):244-53. doi: 10.12968/jowc.2012.21.5.244.


PMID- 22584638
OWN - NLM
STAT- MEDLINE
DCOM- 20130924
LR  - 20211021
IS  - 1414-431X (Electronic)
IS  - 0100-879X (Linking)
VI  - 45
IP  - 7
DP  - 2012 Jul
TI  - Comparison of the variability of the onset and recovery from neuromuscular
      blockade with cisatracurium versus rocuronium in elderly patients under total
      intravenous anesthesia.
PG  - 676-80
LID - S0100-879X2012007500076 [pii]
AB  - This study was designed to compare the variability of the onset and offset of the
      effect of two neuromuscular blocking drugs with different elimination pathways in
      adult and elderly patients during total intravenous anesthesia (TIVA). After
      Ethics Committee approval and patients' informed consent, the drugs were compared
      in 40 adult and 40 elderly patients scheduled for elective surgery under TIVA
      with tracheal intubation who were randomized to receive a single bolus dose of
      0.15 mg/kg cisatracurium or 0.9 mg/kg rocuronium. The time of onset of maximum
      depression, duration of action, and recovery index time were measured and
      recorded for each patient and variability is reported as means +/- standard
      deviation. Time of onset was significantly shorter for rocuronium than
      cisatracurium for the adult and elderly groups (P = 0.000), but the variability
      of cisatracurium was significantly greater compared with rocuronium for the same 
      age groups (93.25 vs 37.01 s in the adult group and 64.56 vs 33.75 s in the
      elderly group; P = 0.000). The duration of the effect in the elderly group
      receiving rocuronium was significantly longer than in the elderly group receiving
      cisatracurium, and the variability of the duration was significantly greater in
      the rocuronium group than in the cisatracurium group. Mean time of recovery was
      significantly longer for the elderly group receiving rocuronium than for the
      elderly group receiving cisatracurium (P = 0.022), and variability was also
      greater (P = 0.002). Both drugs favored good intubating conditions. In
      conclusion, cisatracurium showed less variability in these parameters than
      rocuronium, especially in the elderly, a fact that may be of particular clinical 
      interest.
FAU - Xiaobo, Feng
AU  - Xiaobo F
AD  - Department of Anesthesiology, Zhongnan Hospital, Wuhan University, Wuhan, China.
FAU - Jianjuan, Ke
AU  - Jianjuan K
FAU - Yanlin, Wang
AU  - Yanlin W
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20120517
PL  - Brazil
TA  - Braz J Med Biol Res
JT  - Brazilian journal of medical and biological research = Revista brasileira de
      pesquisas medicas e biologicas
JID - 8112917
RN  - 0 (Androstanols)
RN  - 0 (Neuromuscular Blocking Agents)
RN  - 2GQ1IRY63P (Atracurium)
RN  - QX62KLI41N (cisatracurium)
RN  - WRE554RFEZ (Rocuronium)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Androstanols/*administration & dosage/pharmacokinetics
MH  - *Anesthesia Recovery Period
MH  - *Anesthesia, Intravenous
MH  - Atracurium/administration & dosage/*analogs & derivatives/pharmacokinetics
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Monitoring, Intraoperative
MH  - Neuromuscular Blockade/*methods
MH  - Neuromuscular Blocking Agents/*administration & dosage/pharmacokinetics
MH  - Rocuronium
MH  - Young Adult
PMC - PMC3854273
EDAT- 2012/05/16 06:00
MHDA- 2013/09/26 06:00
CRDT- 2012/05/16 06:00
PHST- 2011/08/10 00:00 [received]
PHST- 2012/04/24 00:00 [accepted]
PHST- 2012/05/16 06:00 [entrez]
PHST- 2012/05/16 06:00 [pubmed]
PHST- 2013/09/26 06:00 [medline]
AID - S0100-879X2012007500076 [pii]
AID - 10.1590/s0100-879x2012007500076 [doi]
PST - ppublish
SO  - Braz J Med Biol Res. 2012 Jul;45(7):676-80. doi: 10.1590/s0100-879x2012007500076.
      Epub 2012 May 17.


PMID- 22584512
OWN - NLM
STAT- MEDLINE
DCOM- 20120927
LR  - 20211021
IS  - 2242-3982 (Electronic)
IS  - 1239-9736 (Linking)
VI  - 71
IP  - 0
DP  - 2012 May 8
TI  - Youth researching youth: benefits, limitations and ethical considerations within 
      a participatory research process.
PG  - 1-9
LID - 10.3402/ijch.v71i0.18415 [doi]
AB  - OBJECTIVES: To examine the benefits, limitations and ethical issues associated
      with conducting participatory research on tobacco use using youth to research
      other youth. STUDY DESIGN: Community-based participatory research. METHODS:
      Research on tobacco use was conducted with students in the K'alemi Dene School
      and Kaw Tay Whee School in the Northwest Territories, Canada, using PhotoVoice.
      The Grade 9-12 students acted as researchers. Researcher reflections and
      observations were assessed using "member checking," whereby students, teachers
      and community partners could agree or disagree with the researcher's
      interpretation. The students and teachers were further asked informally to share 
      their own reflections and observations on this process. RESULTS AND CONCLUSIONS: 
      Using youth to research other youth within a participatory research framework had
      many benefits for the quality of the research, the youth researchers and the
      community. The research was perceived by the researchers and participants to be
      more valid and credible. The approach was more appropriate for the students, and 
      the youth researchers gained valuable research experience and a sense of
      ownership of both the research process and results. Viewing smoking through their
      children's eyes was seen by the community to be a powerful and effective means of
      creating awareness of the community environment. Limitations of the approach were
      residual response bias of participants, the short period of time to conduct the
      research and failure to fully explore student motivations to smoke or not to
      smoke. Ethical considerations included conducting research with minors,
      difficulties in obtaining written parental consent, decisions on cameras
      (disposable versus digital) and representation of all participants in the final
      research product.
FAU - Jardine, Cynthia G
AU  - Jardine CG
AD  - School of Public Health, University of Alberta, Edmonton, AB, Canada.
      cindy.jardine@ualberta.ca
FAU - James, Angela
AU  - James A
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20120508
PL  - United States
TA  - Int J Circumpolar Health
JT  - International journal of circumpolar health
JID - 9713056
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Cohort Studies
MH  - Community-Based Participatory Research/ethics/*methods/standards
MH  - *Ethics, Medical
MH  - Humans
MH  - Indians, North American
MH  - Interviews as Topic
MH  - Northwest Territories/epidemiology
MH  - Research Personnel
MH  - Schools
MH  - Smoking/*epidemiology
MH  - Young Adult
PMC - PMC3417519
EDAT- 2012/05/16 06:00
MHDA- 2012/09/28 06:00
CRDT- 2012/05/16 06:00
PHST- 2011/07/04 00:00 [received]
PHST- 2012/03/18 00:00 [revised]
PHST- 2012/03/19 00:00 [accepted]
PHST- 2012/05/16 06:00 [entrez]
PHST- 2012/05/16 06:00 [pubmed]
PHST- 2012/09/28 06:00 [medline]
AID - 18415 [pii]
AID - 10.3402/ijch.v71i0.18415 [doi]
PST - epublish
SO  - Int J Circumpolar Health. 2012 May 8;71(0):1-9. doi: 10.3402/ijch.v71i0.18415.


PMID- 22584422
OWN - NLM
STAT- MEDLINE
DCOM- 20121029
LR  - 20120522
IS  - 1538-2982 (Electronic)
IS  - 1056-6163 (Linking)
VI  - 21
IP  - 3
DP  - 2012 Jun
TI  - A current dental ethics dilemma.
PG  - 161
LID - 10.1097/ID.0b013e318258ec5d [doi]
FAU - Misch, Carl E
AU  - Misch CE
LA  - eng
PT  - Editorial
PL  - United States
TA  - Implant Dent
JT  - Implant dentistry
JID - 9206481
RN  - 0 (Dental Implants)
MH  - Dental Implants/*ethics
MH  - *Ethics, Dental
MH  - Humans
MH  - Tooth Extraction/*ethics
EDAT- 2012/05/16 06:00
MHDA- 2012/10/30 06:00
CRDT- 2012/05/16 06:00
PHST- 2012/05/16 06:00 [entrez]
PHST- 2012/05/16 06:00 [pubmed]
PHST- 2012/10/30 06:00 [medline]
AID - 10.1097/ID.0b013e318258ec5d [doi]
PST - ppublish
SO  - Implant Dent. 2012 Jun;21(3):161. doi: 10.1097/ID.0b013e318258ec5d.


PMID- 22584149
OWN - NLM
STAT- MEDLINE
DCOM- 20131216
LR  - 20151119
IS  - 1938-2715 (Electronic)
IS  - 1049-9091 (Linking)
VI  - 30
IP  - 2
DP  - 2013 Mar
TI  - Effect of a compassion-focused training program in palliative care education for 
      medical students.
PG  - 114-20
LID - 10.1177/1049909112445463 [doi]
AB  - BACKGROUND: Compassion is the key value of humanities perspective. Little is
      known, however, concerning the impact of enhancing compassion on ethical decision
      making in end-of-life care. METHODS: A total of 251 preclinical medical students 
      were enrolled in a palliative care training course. A structured self-report
      questionnaire was administered before and after training. RESULTS: Experience
      with caring for patients with terminal cancer was positively related to
      improvement in the decision of "truth telling is helpful to a good death." In
      addition, improvement in the perception of "compassionate care" was correlated
      with higher improvement in the decision of "discharge planning and home care."
      CONCLUSION: Compassion-focused training program can be helpful to improve medical
      students' competence in making more appropriate ethical decisions in end-of-life 
      care.
FAU - Shih, Chih-Yuan
AU  - Shih CY
AD  - Department of Family Medicine, National Taiwan University Hospital Jin-shan
      Branch, Taipei, Taiwan.
FAU - Hu, Wen-Yu
AU  - Hu WY
FAU - Lee, Long-Teng
AU  - Lee LT
FAU - Yao, Chien-An
AU  - Yao CA
FAU - Chen, Ching-Yu
AU  - Chen CY
FAU - Chiu, Tai-Yuan
AU  - Chiu TY
LA  - eng
PT  - Journal Article
DEP - 20120514
PL  - United States
TA  - Am J Hosp Palliat Care
JT  - The American journal of hospice & palliative care
JID - 9008229
SB  - IM
MH  - Adult
MH  - Attitude of Health Personnel
MH  - Cross-Sectional Studies
MH  - Education, Medical/*methods
MH  - *Empathy
MH  - Female
MH  - Humans
MH  - Male
MH  - Neoplasms/therapy
MH  - *Palliative Care/ethics/psychology
MH  - Students, Medical/psychology
MH  - Surveys and Questionnaires
MH  - Terminal Care/methods/psychology
MH  - Young Adult
EDAT- 2012/05/16 06:00
MHDA- 2013/12/18 06:00
CRDT- 2012/05/16 06:00
PHST- 2012/05/16 06:00 [entrez]
PHST- 2012/05/16 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
AID - 1049909112445463 [pii]
AID - 10.1177/1049909112445463 [doi]
PST - ppublish
SO  - Am J Hosp Palliat Care. 2013 Mar;30(2):114-20. doi: 10.1177/1049909112445463.
      Epub 2012 May 14.


PMID- 22583709
OWN - NLM
STAT- MEDLINE
DCOM- 20120724
LR  - 20120515
IS  - 1097-6787 (Electronic)
IS  - 0190-9622 (Linking)
VI  - 66
IP  - 6
DP  - 2012 Jun
TI  - The unsolicited ominous diagnosis: legal, moral, and ethical considerations.
PG  - 985-7
LID - 10.1016/j.jaad.2011.12.026 [doi]
FAU - Grant-Kels, Jane M
AU  - Grant-Kels JM
AD  - Department of Dermatology, University of Connecticut Health Center, Farmington,
      Connecticut 06032, USA. grant@uchc.edu
FAU - Anderson, Julia K
AU  - Anderson JK
FAU - Kels, Barry D
AU  - Kels BD
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Am Acad Dermatol
JT  - Journal of the American Academy of Dermatology
JID - 7907132
SB  - IM
MH  - Adult
MH  - Counseling/ethics/legislation & jurisprudence
MH  - *Ethics, Medical
MH  - Humans
MH  - Male
MH  - Melanoma/diagnosis
MH  - Physician-Patient Relations/ethics
MH  - Referral and Consultation/*ethics/*legislation & jurisprudence
MH  - Skin Neoplasms/diagnosis
MH  - Truth Disclosure/*ethics
EDAT- 2012/05/16 06:00
MHDA- 2012/07/25 06:00
CRDT- 2012/05/16 06:00
PHST- 2011/10/18 00:00 [received]
PHST- 2011/12/19 00:00 [revised]
PHST- 2011/12/22 00:00 [accepted]
PHST- 2012/05/16 06:00 [entrez]
PHST- 2012/05/16 06:00 [pubmed]
PHST- 2012/07/25 06:00 [medline]
AID - S0190-9622(11)02361-9 [pii]
AID - 10.1016/j.jaad.2011.12.026 [doi]
PST - ppublish
SO  - J Am Acad Dermatol. 2012 Jun;66(6):985-7. doi: 10.1016/j.jaad.2011.12.026.


PMID- 22583349
OWN - NLM
STAT- MEDLINE
DCOM- 20120910
LR  - 20181201
IS  - 1935-990X (Electronic)
IS  - 0003-066X (Linking)
VI  - 67
IP  - 4
DP  - 2012 May-Jun
TI  - A plea for virtue in ethics.
PG  - 325; discussion 325-6
LID - 10.1037/a0028162 [doi]
AB  - Comments on the original article, "Nonrational processes in ethical decision
      making" by M. D. Rogerson et al (see record 2011-19198-001). The current authors 
      suggest that Rogerson, Gottlieb, Handelsman, Knapp, and Younggren (October 2011) 
      presumed that the only ethical theories available for grounding decision-making
      models are of the rational, neoliberal variety. Rogerson et al stated,
      "Contextual, interpersonal, and intuitive factors are inextricably linked and
      inexorably influential in the process of ethical decision making. Ethical theory 
      would benefit from encompassing these subtle yet powerful forces" (Rogerson et
      al., 2011, p. 616). They sought to augment these models with a cluster of
      contextual considerations, appending to them accounts of emotion, context, and
      intuition. First, notwithstanding the theories attributed to (the caricature of) 
      Kant and his ilk, there are several ethical theories that include an account of
      what Rogerson et al. (2011) consider to be "nonrational" processes. From feminist
      theories to narrative ethics, sophisticated contextual theories have been
      developed and are readily available. Second, we question whether thick contextual
      considerations can simply be tacked on to extant models of decision making
      originally built upon a philosophical foundation that assumes a rational,
      autonomous agent who deliberates independently and logically.
FAU - Sisti, Dominic A
AU  - Sisti DA
AD  - Department of Medical Ethics and Health Policy, University of Pennsylvania,
      Philadelphia, PA 19104, USA. sistid@mail.med.upenn.edu
FAU - Baum-Baicker, Cynthia
AU  - Baum-Baicker C
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am Psychol
JT  - The American psychologist
JID - 0370521
SB  - IM
CON - Am Psychol. 2011 Oct;66(7):614-23. PMID: 21875170
MH  - Decision Making/*ethics
MH  - Emotions/*ethics
MH  - Humans
MH  - Intuition/*ethics
EDAT- 2012/05/16 06:00
MHDA- 2012/09/11 06:00
CRDT- 2012/05/16 06:00
PHST- 2012/05/16 06:00 [entrez]
PHST- 2012/05/16 06:00 [pubmed]
PHST- 2012/09/11 06:00 [medline]
AID - 2012-12428-010 [pii]
AID - 10.1037/a0028162 [doi]
PST - ppublish
SO  - Am Psychol. 2012 May-Jun;67(4):325; discussion 325-6. doi: 10.1037/a0028162.


PMID- 22583348
OWN - NLM
STAT- MEDLINE
DCOM- 20120910
LR  - 20181201
IS  - 1935-990X (Electronic)
IS  - 0003-066X (Linking)
VI  - 67
IP  - 4
DP  - 2012 May-Jun
TI  - Ethical? Toward whom?
PG  - 324-5; discussion 325-6
LID - 10.1037/a0028119 [doi]
AB  - Comments on the original article, "Nonrational processes in ethical decision
      making" by M. D. Rogerson et al (see record 2011-19198-001). Among the many
      insightful points made by Rogerson, Gottlieb, Handelsman, Knapp, and Younggren
      (October 2011) regarding nonrational processes in ethical decision making, one
      deserves further explication: Many of psychologists' ethical decisions lead to
      actions done to someone. Unfortunately, frameworks and models of ethical decision
      making frequently neglect this fact by implying that the decisions happen in the 
      abstract, but in truth, these decisions often affect a specific recipient.
      Importantly, the characteristics of that specific recipient, especially as
      perceived by the psychologist, can have a powerful impact on the process of
      ethical decision making (Caughron et al., 2011). It would be wise to add such a
      hypothetical to the list of specific questions that Rogerson et al recommended
      psychologists ask themselves: Would I make the same ethical decision if the
      person(s) toward whom the decision is directed had different characteristics?
FAU - Pomerantz, Andrew M
AU  - Pomerantz AM
AD  - Department of Psychology, Southern Illinois University, Edwardsville, IL 62026,
      USA. apomera@siue.edu
LA  - eng
PT  - Journal Article
PT  - Comment
PL  - United States
TA  - Am Psychol
JT  - The American psychologist
JID - 0370521
SB  - IM
CON - Am Psychol. 2011 Oct;66(7):614-23. PMID: 21875170
MH  - Decision Making/*ethics
MH  - Emotions/*ethics
MH  - Humans
MH  - Intuition/*ethics
EDAT- 2012/05/16 06:00
MHDA- 2012/09/11 06:00
CRDT- 2012/05/16 06:00
PHST- 2012/05/16 06:00 [entrez]
PHST- 2012/05/16 06:00 [pubmed]
PHST- 2012/09/11 06:00 [medline]
AID - 2012-12428-009 [pii]
AID - 10.1037/a0028119 [doi]
PST - ppublish
SO  - Am Psychol. 2012 May-Jun;67(4):324-5; discussion 325-6. doi: 10.1037/a0028119.


PMID- 22583154
OWN - NLM
STAT- MEDLINE
DCOM- 20131122
LR  - 20130206
IS  - 1471-6712 (Electronic)
IS  - 0283-9318 (Linking)
VI  - 27
IP  - 1
DP  - 2013 Mar
TI  - Life-sharing experiences of relatives of persons with severe mental illness - a
      phenomenographic study.
PG  - 99-107
LID - 10.1111/j.1471-6712.2012.01007.x [doi]
AB  - Relatives of those suffering from severe mental illness experience multiple
      challenges and a complex life situation. The aim of this study was to describe
      life-sharing experiences from the perspective of relatives of someone with severe
      mental illness. A qualitative, descriptive study was performed, and interviews
      were carried out with eighteen relatives of persons with severe mental illness. A
      phenomenographic analysis, according to the steps described by Dahlgren and
      Fallsberg, was used to describe the relatives' conceptions of their situation.
      The findings show that the experiences of these relatives can be summarized in
      one main category: 'The art of balancing between multiple concerns'. Two
      descriptive categories emerged: 'Making choices on behalf of others and oneself' 
      and 'Constantly struggling between opposing feelings and between reflections'.
      Relatives report that they have to manoeuvre between different ways to act and to
      prioritize between different wishes and needs. In addition, they face a wide
      range of strong feelings and they search for hope and meaning. Relatives of
      someone with severe mental illness have to balance multiple concerns, which
      induce ethical dilemmas. They felt love, compassion or sense of duty towards the 
      mentally ill person. The changeable situation made it difficult for the relatives
      to establish a balance in their lives. To be able to prioritize some private time
      was important. Relatives need own support and sufficient follow-up of the
      mentally ill next of kin from the mental health services.
CI  - (c) 2012 The Authors. Scandinavian Journal of Caring Sciences (c) 2012 Nordic
      College of Caring Science.
FAU - Weimand, Bente M
AU  - Weimand BM
AD  - Department of Nursing, Faculty of Social and Life Sciences, Karlstad University, 
      Karlstad, Sweden. bente.weimand@ahus.no
FAU - Hall-Lord, Marie Louise
AU  - Hall-Lord ML
FAU - Sallstrom, Christina
AU  - Sallstrom C
FAU - Hedelin, Birgitta
AU  - Hedelin B
LA  - eng
PT  - Journal Article
DEP - 20120514
PL  - Sweden
TA  - Scand J Caring Sci
JT  - Scandinavian journal of caring sciences
JID - 8804206
MH  - Cross-Sectional Studies
MH  - Family/*psychology
MH  - Humans
MH  - Life Change Events
MH  - Mental Disorders/*psychology/therapy
MH  - Norway
EDAT- 2012/05/16 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/05/16 06:00
PHST- 2012/05/16 06:00 [entrez]
PHST- 2012/05/16 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1111/j.1471-6712.2012.01007.x [doi]
PST - ppublish
SO  - Scand J Caring Sci. 2013 Mar;27(1):99-107. doi: 10.1111/j.1471-6712.2012.01007.x.
      Epub 2012 May 14.


PMID- 22583118
OWN - NLM
STAT- MEDLINE
DCOM- 20131122
LR  - 20130206
IS  - 1471-6712 (Electronic)
IS  - 0283-9318 (Linking)
VI  - 27
IP  - 1
DP  - 2013 Mar
TI  - Doctor-patient communication and cancer patients' choice of alternative therapies
      as supplement or alternative to conventional care.
PG  - 70-6
LID - 10.1111/j.1471-6712.2012.01002.x [doi]
AB  - Cancer patients' use of complementary and alternative medicine (CAM) is
      widespread, despite the fact that clinical studies validating the efficacy of CAM
      remain sparse in the Nordic countries. The purpose of this study was to explore
      possible connections between cancer patients' communication experiences with
      doctors and the decision to use CAM as either supplement or alternative to
      conventional treatment (CT). The Regional Committee for Medical and Health
      Research Ethics and the Norwegian Data Inspectorate approved the study. From a
      group of 52 cancer patients with self-reported positive experiences from use of
      CAM, 13 were selected for qualitative interviews. Six used CAM as supplement, and
      seven as alternative to CT, periodically or permanently. Communication
      experiences with 46 doctors were described. The analysis revealed three
      connections between doctor-patient communication and patients' treatment
      decisions: (i) negative communication experiences because of the use of CAM; (ii)
      negative communication experiences resulted in the decision to use CAM, and in
      some cases to decline CT; and (iii) positive communication experiences led to the
      decision to use CAM as supplement, not alternative to CT. The patients, including
      the decliners of CT, wanted to discuss treatment decisions in well-functioning
      interpersonal processes with supportive doctors. In doctors' practices and
      education of doctors, a greater awareness of potential positive and negative
      outcomes of doctor-patient communication that concern CAM issues could be of
      importance. More research is needed to safeguard CAM users' treatment decisions
      and their relationship to conventional health care.
CI  - (c) 2012 The Author. Scandinavian Journal of Caring Sciences (c) 2012 Nordic
      College of Caring Science.
FAU - Salamonsen, Anita
AU  - Salamonsen A
AD  - The National Research Center in Complementary and Alternative Medicine (NAFKAM), 
      Department of Community Medicine, Faculty of Health Sciences, University of
      Tromso, Tromso, Norway. anita.salamonsen@uit.no
LA  - eng
PT  - Journal Article
DEP - 20120514
PL  - Sweden
TA  - Scand J Caring Sci
JT  - Scandinavian journal of caring sciences
JID - 8804206
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Communication
MH  - *Complementary Therapies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/*psychology/*therapy
MH  - Norway
MH  - *Physician-Patient Relations
EDAT- 2012/05/16 06:00
MHDA- 2013/12/16 06:00
CRDT- 2012/05/16 06:00
PHST- 2012/05/16 06:00 [entrez]
PHST- 2012/05/16 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1111/j.1471-6712.2012.01002.x [doi]
PST - ppublish
SO  - Scand J Caring Sci. 2013 Mar;27(1):70-6. doi: 10.1111/j.1471-6712.2012.01002.x.
      Epub 2012 May 14.


PMID- 22582933
OWN - NLM
STAT- MEDLINE
DCOM- 20120928
LR  - 20190116
IS  - 1939-1560 (Electronic)
IS  - 1045-3830 (Linking)
VI  - 27
IP  - 1
DP  - 2012 Mar
TI  - Significant differences in pediatric psychotropic side effects: Implications for 
      school performance.
PG  - 4-28
LID - 10.1037/a0027419 [doi]
AB  - Some side effects (SEs) of increasingly prescribed psychotropic medications can
      impact student performance in school. SE risk varies, even among drugs from the
      same class (e.g., antidepressants). Knowing which SEs occur significantly more
      often than others may enable school psychologists to enhance collaborative
      risk-benefit analysis, medication monitoring, data-based decision-making, and
      inform mitigation efforts. SE data from Full Prescribing Information (PI) on the 
      FDA website for ADHD drugs, atypical antipsychotics, and antidepressants with
      pediatric indications were analyzed. Risk ratios (RR) are reported for each drug 
      within a category compared with placebo. RR tables and graphs inform the reader
      about SE incidence differences for each drug and provide clear evidence of the
      wide variability in SE incidence in the FDA data. Breslow-Day and Cochran
      Mantel-Haenszel methods were used to test for drug-placebo SE differences and to 
      test for significance across drugs within each category based on odds ratios
      (ORs). Significant drug-placebo differences were found for each drug compared
      with placebo, when odds were pooled across all drugs in a category compared with 
      placebo, and between some drugs within categories. Unexpectedly, many large RR
      differences did not reach significance. Potential explanations are offered,
      including limitations of the FDA data sets and statistical and methodological
      issues. Future research directions are offered. The potential impact of certain
      SEs on school performance, mitigation strategies, and the potential role of the
      school psychologist is discussed, with consideration for ethical and legal
      limitations.
CI  - (c) 2012 APA, all rights reserved.
FAU - Kubiszyn, Thomas
AU  - Kubiszyn T
AD  - Department of Educational Psychology.
FAU - Mire, Sarah
AU  - Mire S
AD  - Department of Educational Psychology.
FAU - Dutt, Sonia
AU  - Dutt S
AD  - Department of Educational Psychology.
FAU - Papathopoulos, Katina
AU  - Papathopoulos K
AD  - Department of Educational Psychology.
FAU - Burridge, Andrea Backsheider
AU  - Burridge AB
AD  - Department of Educational Psychology.
LA  - eng
PT  - Clinical Trial, Phase III
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Sch Psychol Q
JT  - School psychology quarterly : the official journal of the Division of School
      Psychology, American Psychological Association
JID - 9102245
RN  - 0 (Antidepressive Agents)
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Placebos)
SB  - IM
MH  - *Achievement
MH  - Adolescent
MH  - Antidepressive Agents/*adverse effects/pharmacology/therapeutic use
MH  - Antipsychotic Agents/*adverse effects/pharmacology/therapeutic use
MH  - Attention Deficit Disorder with Hyperactivity/diagnosis/drug therapy/*psychology
MH  - Child
MH  - Conduct Disorder/complications/diagnosis
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Male
MH  - Odds Ratio
MH  - Placebos
MH  - *Psychology, Child
MH  - *Schools
MH  - Social Class
MH  - Stress, Psychological/complications/psychology
MH  - United States
MH  - United States Food and Drug Administration
EDAT- 2012/05/16 06:00
MHDA- 2012/09/29 06:00
CRDT- 2012/05/16 06:00
PHST- 2012/05/16 06:00 [entrez]
PHST- 2012/05/16 06:00 [pubmed]
PHST- 2012/09/29 06:00 [medline]
AID - 2012-12563-002 [pii]
AID - 10.1037/a0027419 [doi]
PST - ppublish
SO  - Sch Psychol Q. 2012 Mar;27(1):4-28. doi: 10.1037/a0027419.


PMID- 22581930
OWN - NLM
STAT- MEDLINE
DCOM- 20120820
LR  - 20220331
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Linking)
VI  - 78
IP  - 24
DP  - 2012 Jun 12
TI  - "Undiagnosing" multiple sclerosis: the challenge of misdiagnosis in MS.
PG  - 1986-91
LID - 10.1212/WNL.0b013e318259e1b2 [doi]
AB  - OBJECTIVE: To describe the clinical characteristics of encounters with patients
      misdiagnosed with multiple sclerosis (MS). METHODS: A cross-sectional
      Internet-based physician survey of MS specialists was performed. RESULTS: The
      response rate for the survey was 50.4%. Of those who responded, the majority
      (95%) reported having evaluated 1 or more patients who had been diagnosed with
      MS, but who they strongly felt did not have MS, within the last year. The
      majority of respondents (>90%) also reported the use of disease-modifying therapy
      in a proportion of these patients. Most respondents (94%) found clinical
      encounters with these patients equally or more challenging than giving a new
      diagnosis of MS. Fourteen percent of respondents reported that they did not
      always inform such patients of their opinion that they did not have MS.
      CONCLUSIONS: The misdiagnosis of MS is common and has significant consequences
      for patient care and health care system costs. Caring for a patient with a
      misdiagnosis of MS is challenging, and at times honest disclosure of a
      misdiagnosis represents an important ethical concern for neurologists. More data 
      are needed on this patient population to improve diagnostic acumen and the care
      of these patients.
FAU - Solomon, Andrew J
AU  - Solomon AJ
AD  - Department of Neurology, Fletcher Allen Heath Care, University Health Center,
      University of Vermont College of Medicine, Burlington, VT, USA.
      andrew.solomon@uvm.edu
FAU - Klein, Eran P
AU  - Klein EP
FAU - Bourdette, Dennis
AU  - Bourdette D
LA  - eng
GR  - UL1 TR000128/TR/NCATS NIH HHS/United States
GR  - UL1 RR024140/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20120511
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
SB  - IM
CIN - Neurology. 2012 Jun 12;78(24):1904-6. PMID: 22581931
MH  - Cross-Sectional Studies
MH  - Diagnostic Errors/*economics
MH  - *Health Care Costs
MH  - Health Care Surveys
MH  - Humans
MH  - Multiple Sclerosis/*diagnosis/economics
MH  - Neurology/economics
PMC - PMC3369504
EDAT- 2012/05/15 06:00
MHDA- 2012/08/21 06:00
CRDT- 2012/05/15 06:00
PHST- 2012/05/15 06:00 [entrez]
PHST- 2012/05/15 06:00 [pubmed]
PHST- 2012/08/21 06:00 [medline]
AID - WNL.0b013e318259e1b2 [pii]
AID - 10.1212/WNL.0b013e318259e1b2 [doi]
PST - ppublish
SO  - Neurology. 2012 Jun 12;78(24):1986-91. doi: 10.1212/WNL.0b013e318259e1b2. Epub
      2012 May 11.


PMID- 22581929
OWN - NLM
STAT- MEDLINE
DCOM- 20120820
LR  - 20120612
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Linking)
VI  - 78
IP  - 24
DP  - 2012 Jun 12
TI  - A touch of MS: therapeutic mislabeling.
PG  - 1981-5
LID - 10.1212/WNL.0b013e318259e0ec [doi]
AB  - When psychogenic symptomatology is at play, a spectrum of ethical problems and
      considerations arise when patients want, and at times, insist on being given an
      inaccurate neurologic diagnosis. We use the example of multiple sclerosis (MS) to
      highlight the value considerations for clinicians when they face these types of
      cases. Given the ambiguities involved in its diagnosis and the significant risks 
      of its treatment, MS represents a rich case study. This discussion highlights the
      potential harms of mislabeling such patients with MS when the neurologist is
      confident they do not have MS and offers suggestions about how to approach and
      manage these patients. Despite being expedient and well-intentioned, labeling
      psychogenic symptoms with a medically inaccurate diagnosis, such as a "touch of
      MS," constitutes a "therapeutic mislabeling" and sacrifices ethically important
      values incommensurate with the benefits gained.
FAU - Boissy, Adrienne R
AU  - Boissy AR
AD  - Mellen Center for Multiple Sclerosis and Center for Neuroethics, Cleveland Clinic
      Foundation, Cleveland, OH, USA. BOISSYA@ccf.org
FAU - Ford, Paul J
AU  - Ford PJ
LA  - eng
PT  - Journal Article
DEP - 20120511
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
SB  - IM
CIN - Neurology. 2012 Jun 12;78(24):1904-6. PMID: 22581931
MH  - Diagnostic Techniques, Neurological/*ethics
MH  - Humans
MH  - Multiple Sclerosis/diagnosis
MH  - Neurology/*ethics
MH  - Patient Acceptance of Health Care
EDAT- 2012/05/15 06:00
MHDA- 2012/08/21 06:00
CRDT- 2012/05/15 06:00
PHST- 2012/05/15 06:00 [entrez]
PHST- 2012/05/15 06:00 [pubmed]
PHST- 2012/08/21 06:00 [medline]
AID - WNL.0b013e318259e0ec [pii]
AID - 10.1212/WNL.0b013e318259e0ec [doi]
PST - ppublish
SO  - Neurology. 2012 Jun 12;78(24):1981-5. doi: 10.1212/WNL.0b013e318259e0ec. Epub
      2012 May 11.


PMID- 22581751
OWN - NLM
STAT- MEDLINE
DCOM- 20121022
LR  - 20220321
IS  - 1520-6017 (Electronic)
IS  - 0022-3549 (Linking)
VI  - 101
IP  - 8
DP  - 2012 Aug
TI  - Prevalidation of a human cornea construct as an alternative to animal corneas for
      in vitro drug absorption studies.
PG  - 2976-88
LID - 10.1002/jps.23190 [doi]
AB  - The use of ophthalmic drugs has increased consistently over the past few decades.
      Currently, most research is conducted using in vivo and ex vivo animal
      experiments; however, they have many disadvantages, including ethical concerns,
      high costs, the questionable extension of animal results to humans, and poor
      standardization. Although several cell culture-based cornea models have been
      developed, none have been validated and accepted for general use. In this study, 
      a standardized, three-dimensional model of the human cornea (Hemicornea, HC)
      based on immortalized human corneal cells and cultivated in serum-free conditions
      was developed for drug absorption studies and prevalidated using compounds with a
      wide range of molecular characteristics (sodium fluorescein, rhodamine B,
      fluorescein isothiocyanate-labeled dextran, aciclovir, bimatoprost,
      dexamethasone, and timolol maleate). The HC model was independently cultured in
      three different laboratories, and the intralaboratory and interlaboratory
      reproducibility was analyzed and compared with the rabbit cornea. This analysis
      showed that the HC has a barrier in the same range as excised animal corneas,
      although with a higher reproducibility and lower variability. Because of the
      demonstrated transferability, the HC represents a promising in vitro alternative 
      to the use of ex vivo tissue and offers a well-defined and standardized system
      for drug absorption studies.
CI  - Copyright (c) 2012 Wiley Periodicals, Inc.
FAU - Hahne, Matthias
AU  - Hahne M
AD  - Institut fur Pharmazeutische Technologie, Technische Universitat Braunschweig,
      Braunschweig, Germany.
FAU - Zorn-Kruppa, Michaela
AU  - Zorn-Kruppa M
FAU - Guzman, Gustavo
AU  - Guzman G
FAU - Brandner, Johanna M
AU  - Brandner JM
FAU - Haltner-Ukomado, Eleonore
AU  - Haltner-Ukomado E
FAU - Watzig, Hermann
AU  - Watzig H
FAU - Reichl, Stephan
AU  - Reichl S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120511
PL  - United States
TA  - J Pharm Sci
JT  - Journal of pharmaceutical sciences
JID - 2985195R
RN  - 0 (Ophthalmic Solutions)
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Administration, Ophthalmic
MH  - Animals
MH  - Cell Culture Techniques
MH  - Cell Line
MH  - Epithelium, Corneal/*cytology/*metabolism/ultrastructure
MH  - Female
MH  - Humans
MH  - Ophthalmic Solutions/*administration & dosage
MH  - Pharmaceutical Preparations/*administration & dosage
MH  - Pharmacokinetics
MH  - Rabbits
MH  - Swine
EDAT- 2012/05/15 06:00
MHDA- 2012/10/23 06:00
CRDT- 2012/05/15 06:00
PHST- 2012/02/08 00:00 [received]
PHST- 2012/04/17 00:00 [revised]
PHST- 2012/04/24 00:00 [accepted]
PHST- 2012/05/15 06:00 [entrez]
PHST- 2012/05/15 06:00 [pubmed]
PHST- 2012/10/23 06:00 [medline]
AID - 10.1002/jps.23190 [doi]
AID - S0022-3549(15)31481-7 [pii]
PST - ppublish
SO  - J Pharm Sci. 2012 Aug;101(8):2976-88. doi: 10.1002/jps.23190. Epub 2012 May 11.


PMID- 22581507
OWN - NLM
STAT- MEDLINE
DCOM- 20120905
LR  - 20220317
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 19
IP  - 3
DP  - 2012 May
TI  - Personal and professional values grading among midwifery students.
PG  - 399-407
LID - 10.1177/0969733011433921 [doi]
AB  - The purpose of this study was to determine the professional and personal values
      among midwifery students in Turkey and to identify whether the years of study
      affected these values. A total of 192 participants were asked to prioritize 16
      professional and 36 personal values. The relationship between the year of study
      and value ranking was analyzed by Kruskal-Wallis test. The first three of the
      professional values were justice, equality, and human dignity. Equality ranked
      sixth among the personal terminal values, and it increased with the years of
      study. Of personal instrumental values, responsibility and cleanliness ranked
      second and fifth, which are of central importance for the profession of
      midwifery. However, the other two important values, privacy and preventing
      unnecessary suffering, ranked lower when the years of study increased, in other
      words when the students confront clinics. Since these values are important for
      midwifery, ethics courses should be given throughout the midwifery education to
      prepare students for the challenges they face in the clinical environment.
FAU - Ozcan, Muesser
AU  - Ozcan M
AD  - Mugla University High Health School, Turkey. muesserozcan@mu.edu.tr
FAU - Akpinar, Aslihan
AU  - Akpinar A
FAU - Ergin, Ayla B
AU  - Ergin AB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Adolescent
MH  - Adult
MH  - *Codes of Ethics
MH  - Decision Making/ethics
MH  - Family/psychology
MH  - Female
MH  - Humans
MH  - Midwifery/*education/ethics
MH  - Nurse-Patient Relations/*ethics
MH  - Nursing Care/*ethics
MH  - Personality Inventory/*statistics & numerical data
MH  - *Personhood
MH  - Professional Autonomy
MH  - Professional Practice/*ethics
MH  - Psychometrics
MH  - Residence Characteristics/statistics & numerical data
MH  - *Social Values
MH  - Statistics, Nonparametric
MH  - Students, Nursing/*psychology/statistics & numerical data
MH  - Turkey
EDAT- 2012/05/15 06:00
MHDA- 2012/09/06 06:00
CRDT- 2012/05/15 06:00
PHST- 2012/05/15 06:00 [entrez]
PHST- 2012/05/15 06:00 [pubmed]
PHST- 2012/09/06 06:00 [medline]
AID - 19/3/399 [pii]
AID - 10.1177/0969733011433921 [doi]
PST - ppublish
SO  - Nurs Ethics. 2012 May;19(3):399-407. doi: 10.1177/0969733011433921.


PMID- 22581503
OWN - NLM
STAT- MEDLINE
DCOM- 20120905
LR  - 20191210
IS  - 1477-0989 (Electronic)
IS  - 0969-7330 (Linking)
VI  - 19
IP  - 3
DP  - 2012 May
TI  - Reflections on nursing ethics.
PG  - 313-5
LID - 10.1177/0969733012440215 [doi]
FAU - Ghebrehiwet, Tesfamicael
AU  - Ghebrehiwet T
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nurs Ethics
JT  - Nursing ethics
JID - 9433357
MH  - Career Mobility
MH  - *Decision Making
MH  - *Ethics, Nursing
MH  - Ethiopia
MH  - *Health Knowledge, Attitudes, Practice
MH  - Hospital Planning
MH  - Humans
MH  - International Agencies
MH  - Nurse Practitioners/ethics/*psychology
MH  - Nursing, Supervisory/ethics
MH  - Outpatient Clinics, Hospital/*ethics
MH  - Personnel Delegation
MH  - Process Assessment, Health Care/*ethics
EDAT- 2012/05/15 06:00
MHDA- 2012/09/06 06:00
CRDT- 2012/05/15 06:00
PHST- 2012/05/15 06:00 [entrez]
PHST- 2012/05/15 06:00 [pubmed]
PHST- 2012/09/06 06:00 [medline]
AID - 19/3/313 [pii]
AID - 10.1177/0969733012440215 [doi]
PST - ppublish
SO  - Nurs Ethics. 2012 May;19(3):313-5. doi: 10.1177/0969733012440215.


PMID- 22580864
OWN - NLM
STAT- MEDLINE
DCOM- 20121009
LR  - 20181201
IS  - 1213-8118 (Print)
IS  - 1213-8118 (Linking)
VI  - 156
IP  - 1
DP  - 2012 Mar
TI  - Principles of supervision in cognitive behavioural therapy.
PG  - 70-9
LID - 10.5507/bp.2011.022 [doi]
AB  - BACKGROUND: Psychotherapy requires clinical supervision. This is systematic
      guidance of a therapist by a supervisor. Inevitably, there is a question of
      training new high-quality therapists. This is related to supervision of their
      basic training. Later, it is important to provide an opportunity for lifelong
      supervision throughout the entire psychotherapeutic practice. METHOD: PUBMED data
      base was searched for articles using the key words "supervision in CBT",
      "therapeutic relations", "transference", "countertransference", "schema therapy",
      "dialectical behavioral therapy". The search was repeated by changing the key
      word. No language or time constraints were applied. The lists of references of
      articles detected by this computer data base search were examined manually to
      find additional articles. We also used the original texts of A. T. Beck, J. Beck,
      M. Linehan, R. Leahy, J. Young and others. Basically this is a review with
      conclusions about supervision in cognitive behavioral therapy. RESULTS: The task 
      of supervision is obvious - to increase the value of the therapeutic process in
      the client's best interest. At the same time, supervision is an educational
      process in the truest sense of the word, including an opportunity to select one's
      own supervisor. This is a very important procedural aspect since the therapist
      identifies with his/her supervisor, either consciously or unconsciously.
      Establishing the supervisor-supervisee relationship is based on principles
      similar to those in the therapeutic relationship. There is an important parallel 
      reflecting the therapist-client relationship. This is because any changes in the 
      supervisory process are analogically transferred onto the therapist-client
      relationship. Additionally, supervision is oriented towards increasing the
      therapist's competencies. The CBT therapist's basic skills involve good
      theoretical knowledge, professional behaviour towards clients, ability to use
      specific therapeutic strategies for maintaining the therapeutic relationship,
      sensitivity to parallel processes and accomplishment of changes, and adherence to
      ethical norms. Given the fact that during supervision, the supervisee may be in
      any stage of his/ her training, supervision must take into consideration where
      the therapist is in his/her training and development and what he/she has or has
      not learnt. CONCLUSIONS: Both the literature and our experience underscore the
      importance of careful supervision of cognitive behavioral therapy. The
      supervisory relationship is similar to a therapeutic relationship and the
      supervisee also needs security, acceptance and appreciation for his/her
      professional growth. However, there is more freedom in the relationship.
      Supervision may only lead to the supervisee's professional growth if it supports 
      his/her individuality and helps him/her to discover things. Therefore, numerous
      approaches are used in supervision which are associated with the abilities to
      self-reflect and to realize transference and countertransference mechanisms.
FAU - Prasko, Jan
AU  - Prasko J
AD  - Department of Psychiatry, Faculty of Medicine and Dentistry, Palacky University
      Olomouc and University Hospital Olomouc, Czech Republic. prasko@fnol.cz
FAU - Vyskocilova, Jana
AU  - Vyskocilova J
FAU - Slepecky, Milos
AU  - Slepecky M
FAU - Novotny, Miroslav
AU  - Novotny M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Czech Republic
TA  - Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
JT  - Biomedical papers of the Medical Faculty of the University Palacky, Olomouc,
      Czechoslovakia
JID - 101140142
SB  - IM
MH  - Clinical Competence
MH  - Cognitive Behavioral Therapy/*education
MH  - Humans
MH  - *Teaching
EDAT- 2012/05/15 06:00
MHDA- 2012/10/10 06:00
CRDT- 2012/05/15 06:00
PHST- 2012/05/15 06:00 [entrez]
PHST- 2012/05/15 06:00 [pubmed]
PHST- 2012/10/10 06:00 [medline]
AID - 10.5507/bp.2011.022 [doi]
PST - ppublish
SO  - Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2012 Mar;156(1):70-9. doi:
      10.5507/bp.2011.022.


PMID- 22580258
OWN - NLM
STAT- MEDLINE
DCOM- 20120910
LR  - 20120514
IS  - 1969-6213 (Electronic)
IS  - 1774-024X (Linking)
VI  - 8
IP  - 1
DP  - 2012 May 15
TI  - Improving informed consent in percutaneous coronary revascularisation.
PG  - 146-54
LID - 10.4244/EIJV8I1A22 [doi]
LID - EIJV8I1A22 [pii]
AB  - Informed consent is indispensable in contemporary medicine, especially in cases
      where the risks are high or there is true clinical equipoise, as in much invasive
      cardiology and cardiothoracic surgery practice. In this article we illustrate the
      principle of informed consent and describe how consent requirements have become
      more exacting in response to the rise of autonomy as the dominant principle in
      biomedical ethics. We outline some criticisms of informed consent, discuss why
      current requirements may never be achievable, and describe some of the vast
      literature aimed at "solving" the problem. We argue that respect for autonomy is 
      just one of the principles of biomedical ethics and that the implementation of
      this principle must be weighed in the clinical context against the other
      principles, namely beneficence, non-maleficence and justice. The way we implement
      informed consent should be based on an ethical assessment of the clinical
      situation, including the invasiveness of the procedure, equipoise and the
      importance of patient values, and not on practical issues. We conclude that
      focusing on the whole decision-making process, effective communication, and a
      proportionate and individualised approach to consent could go some way to improve
      the experience of many patients in cardiology.
FAU - Bromage, Daniel I
AU  - Bromage DI
AD  - Barts Health NHS Trust, London, United Kingdom.
FAU - Lim, Joanna
AU  - Lim J
FAU - ter Meulen, Ruud
AU  - ter Meulen R
FAU - Ramcharitar, Steve
AU  - Ramcharitar S
LA  - eng
PT  - Journal Article
PT  - Review
PL  - France
TA  - EuroIntervention
JT  - EuroIntervention : journal of EuroPCR in collaboration with the Working Group on 
      Interventional Cardiology of the European Society of Cardiology
JID - 101251040
SB  - IM
MH  - Angioplasty, Balloon, Coronary/adverse effects/*ethics/legislation &
      jurisprudence
MH  - Beneficence
MH  - Communication
MH  - Comprehension
MH  - Forms and Records Control
MH  - Humans
MH  - *Informed Consent
MH  - Patient Education as Topic
MH  - Personal Autonomy
MH  - Physician-Patient Relations
MH  - Risk Assessment
MH  - Risk Factors
MH  - Therapeutic Equipoise
EDAT- 2012/05/15 06:00
MHDA- 2012/09/11 06:00
CRDT- 2012/05/15 06:00
PHST- 2012/05/15 06:00 [entrez]
PHST- 2012/05/15 06:00 [pubmed]
PHST- 2012/09/11 06:00 [medline]
AID - EIJV8I1A22 [pii]
AID - 10.4244/EIJV8I1A22 [doi]
PST - ppublish
SO  - EuroIntervention. 2012 May 15;8(1):146-54. doi: 10.4244/EIJV8I1A22.


PMID- 22580210
OWN - NLM
STAT- MEDLINE
DCOM- 20121217
LR  - 20211021
IS  - 1559-2030 (Electronic)
IS  - 1551-7144 (Linking)
VI  - 33
IP  - 5
DP  - 2012 Sep
TI  - Commonly performed procedures in clinical research: a benchmark for payment.
PG  - 860-8
LID - 10.1016/j.cct.2012.05.001 [doi]
AB  - Slow or insufficient enrollment in clinical research and a high demand for
      research participants raises questions about the need for and use of incentives
      to participate, including payment. Much of the available literature on payment to
      research participants focuses on ethical concerns, and rarely addresses
      guidelines, benchmarks, or formulas to assist investigators to assign or evaluate
      appropriate payment for individuals who take part in clinical research trials and
      procedures. Using four years of data collected about the inconvenience units
      assigned by intramural investigators to selected clinical research procedures
      conducted at the National Institutes of Health (NIH) Clinical Center, this study 
      provides payment benchmarks for commonly performed procedures. Results were
      obtained from data collected on 36,273 incidents of payment made for procedures
      to research participants from August 2004 to August 2008. Analysis of the
      inconvenience units value assigned to specific procedures suggests that despite a
      wide distribution and frequent outliers, a convergence in practice around the
      center of distribution for most procedures does exist. As one of the first
      published studies reporting data reflecting payment amount for specific clinical 
      research procedures, these data can guide investigators and institutional review 
      boards as they establish and review an appropriate amount of payment to offer
      research participants. Our data may be useful in promoting payment standards for 
      procedures, thereby complementing proposals or guidelines that advise payment
      calculations according to time and procedures.
CI  - Published by Elsevier Inc.
FAU - Dominguez, Dinora
AU  - Dominguez D
AD  - Office of Communications, Patient Recruitment, and Public Liaison, NIH Clinical
      Center, USA.
FAU - Jawara, Mandy
AU  - Jawara M
FAU - Martino, Nicole
AU  - Martino N
FAU - Sinaii, Ninet
AU  - Sinaii N
FAU - Grady, Christine
AU  - Grady C
LA  - eng
GR  - Z99 CL999999/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
DEP - 20120509
PL  - United States
TA  - Contemp Clin Trials
JT  - Contemporary clinical trials
JID - 101242342
SB  - IM
MH  - Benchmarking/*economics/ethics
MH  - Clinical Trials as Topic/*economics/ethics
MH  - Humans
MH  - Motivation
MH  - Patient Selection
MH  - Reimbursement, Incentive/*standards
MH  - *Research Design
MH  - Research Subjects/*economics
PMC - PMC3408804
MID - NIHMS379917
EDAT- 2012/05/15 06:00
MHDA- 2012/12/18 06:00
CRDT- 2012/05/15 06:00
PHST- 2011/11/29 00:00 [received]
PHST- 2012/03/29 00:00 [revised]
PHST- 2012/05/01 00:00 [accepted]
PHST- 2012/05/15 06:00 [entrez]
PHST- 2012/05/15 06:00 [pubmed]
PHST- 2012/12/18 06:00 [medline]
AID - S1551-7144(12)00107-3 [pii]
AID - 10.1016/j.cct.2012.05.001 [doi]
PST - ppublish
SO  - Contemp Clin Trials. 2012 Sep;33(5):860-8. doi: 10.1016/j.cct.2012.05.001. Epub
      2012 May 9.


PMID- 22579956
OWN - NLM
STAT- MEDLINE
DCOM- 20130522
LR  - 20130107
IS  - 1552-6917 (Electronic)
IS  - 1055-3290 (Linking)
VI  - 24
IP  - 1
DP  - 2013 Jan-Feb
TI  - Pre-exposure prophylaxis: an ethical discussion.
PG  - 6-10
LID - 10.1016/j.jana.2012.02.005 [doi]
LID - S1055-3290(12)00058-1 [pii]
FAU - Rowniak, Stefan
AU  - Rowniak S
AD  - University of San Francisco, School of Nursing and Health Professions, San
      Francisco, California, USA.
FAU - Portillo, Carmen
AU  - Portillo C
LA  - eng
PT  - Journal Article
DEP - 20120512
PL  - United States
TA  - J Assoc Nurses AIDS Care
JT  - The Journal of the Association of Nurses in AIDS Care : JANAC
JID - 9111870
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - Anti-HIV Agents/*therapeutic use
MH  - Chemoprevention/*ethics
MH  - HIV Infections/*prevention & control
MH  - Humans
MH  - Personal Autonomy
MH  - Professional Autonomy
EDAT- 2012/05/15 06:00
MHDA- 2013/05/23 06:00
CRDT- 2012/05/15 06:00
PHST- 2012/01/16 00:00 [received]
PHST- 2012/02/06 00:00 [accepted]
PHST- 2012/05/15 06:00 [entrez]
PHST- 2012/05/15 06:00 [pubmed]
PHST- 2013/05/23 06:00 [medline]
AID - S1055-3290(12)00058-1 [pii]
AID - 10.1016/j.jana.2012.02.005 [doi]
PST - ppublish
SO  - J Assoc Nurses AIDS Care. 2013 Jan-Feb;24(1):6-10. doi:
      10.1016/j.jana.2012.02.005. Epub 2012 May 12.


PMID- 22579881
OWN - NLM
STAT- MEDLINE
DCOM- 20121130
LR  - 20120806
IS  - 1532-2793 (Electronic)
IS  - 0260-6917 (Linking)
VI  - 32
IP  - 7
DP  - 2012 Oct
TI  - Using the arts and humanities to promote a liberal nursing education: strengths
      and weaknesses.
PG  - 803-10
LID - 10.1016/j.nedt.2012.04.014 [doi]
AB  - BACKGROUND: The requirement that all student nurses in the United Kingdom will be
      educated to degree level from 2013 permits a review of the current state of
      nursing education in university contexts. Recent educational standards for these 
      new programmes (NMC, 2010) allow a liberal, or broad-based, education, with its
      features of breadth of knowledge, formativity, critical thinking and working with
      others, to be considered. OBJECTIVE: Select narratives from a PhD study featuring
      student nurses and nurse teachers exploring the relationship between reading
      literature and poetry and ethical practice are presented to critically support
      the place of liberal education within these programmes. DESIGN: These narratives 
      are drawn from a research study based upon the use of a narrative methodology.
      SETTINGS: The study was set within the educational context of a school of nursing
      and midwifery in one Scottish university. PARTICIPANTS: Eight student nurses and 
      four nurse teachers participated in the study. METHODS: These narratives were
      constructed from data derived from focus groups and individual interviews.
      RESULTS: These narratives suggest that liberal education can be promoted within
      international curricula via careful positioning of, and student nurse engagement 
      with, the arts and humanities. A liberal education can influence student nurses' 
      sense of discernment, enhance their own responsibility for learning, support
      ethical regard for others, provide different perspectives on human experience and
      contribute to a balanced curriculum. Although a liberal education cannot
      guarantee fully skilled and ethically sensitive practitioners, it can contribute 
      towards its achievement. CONCLUSION: The current university education climate
      presents obstacles to the promotion of liberal education. Nevertheless, the
      considerable professional and personal challenges of nursing practice in global
      terms make such an educational preparation essential. If nursing education to
      degree level is to commence from 2013, these principal features of liberal
      education, via these educational standards, must be embedded prominently into new
      programmes.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - McKie, Andrew
AU  - McKie A
AD  - School of Nursing and Midwifery, Faculty of Health and Social Care, Robert Gordon
      University, Garthdee Campus, Aberdeen, AB10 7QG, United Kingdom.
      a.mckie@rgu.ac.uk
LA  - eng
PT  - Journal Article
DEP - 20120512
PL  - Scotland
TA  - Nurse Educ Today
JT  - Nurse education today
JID - 8511379
MH  - *Art
MH  - Education, Nursing, Graduate/*organization & administration
MH  - Humanities/*education
MH  - Humans
MH  - Narration
MH  - Nursing Education Research
MH  - Nursing Evaluation Research
MH  - Nursing Methodology Research
MH  - Scotland
EDAT- 2012/05/15 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/05/15 06:00
PHST- 2011/12/02 00:00 [received]
PHST- 2012/03/01 00:00 [revised]
PHST- 2012/04/12 00:00 [accepted]
PHST- 2012/05/15 06:00 [entrez]
PHST- 2012/05/15 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - S0260-6917(12)00119-0 [pii]
AID - 10.1016/j.nedt.2012.04.014 [doi]
PST - ppublish
SO  - Nurse Educ Today. 2012 Oct;32(7):803-10. doi: 10.1016/j.nedt.2012.04.014. Epub
      2012 May 12.


PMID- 22579513
OWN - NLM
STAT- MEDLINE
DCOM- 20130104
LR  - 20120716
IS  - 1879-3177 (Electronic)
IS  - 0887-2333 (Linking)
VI  - 26
IP  - 6
DP  - 2012 Sep
TI  - Automated neurosphere sorting and plating by the COPAS large particle sorter is a
      suitable method for high-throughput 3D in vitro applications.
PG  - 993-1000
LID - 10.1016/j.tiv.2012.04.025 [doi]
AB  - Existing guidelines for testing developmental neurotoxicity (DNT) propose
      investigations in rodents, which are ethically questionable as well as time and
      cost intensive. Thus, there is international agreement that predictive in vitro
      methods are needed to increase efficiency of testing and limit the number of
      animals used. One of a variety of novel approaches for DNT testing utilizes
      neurospheres, three-dimensional aggregate cultures of primary normal neural
      progenitor cells (NPCs). Because sorting and plating of single neurospheres is
      one of the most time-consuming steps within the assay, the aim of this study was 
      to evaluate if the complex object parametric analyzer and sorter (COPAS PLUS(TM),
      Union Biometrica Inc.) is a suitable tool for automated sorting and plating of
      neurospheres. The results of the comparison of NPC viability, proliferation,
      migration, differentiation and intracellular oxidative stress between manually
      and COPAS sorted and plated neurospheres of different species show that the
      automation by the COPAS instrument does not influence the basic performance of
      neurospheres. Therefore, we consider the COPAS instrument as a useful tool for
      higher throughput neurosphere research in toxicology, neuroregeneration, brain
      development, drug development and brain aging research.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Gassmann, K
AU  - Gassmann K
AD  - Leibniz Research Institute for Environmental Medicine, Department Molecular
      Toxicology, Auf'm Hennekamp 50, 40225 Duesseldorf, Germany.
      Kathrin.gassmann@uni-duesseldorf.de
FAU - Baumann, J
AU  - Baumann J
FAU - Giersiefer, S
AU  - Giersiefer S
FAU - Schuwald, J
AU  - Schuwald J
FAU - Schreiber, T
AU  - Schreiber T
FAU - Merk, H F
AU  - Merk HF
FAU - Fritsche, E
AU  - Fritsche E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120502
PL  - England
TA  - Toxicol In Vitro
JT  - Toxicology in vitro : an international journal published in association with
      BIBRA
JID - 8712158
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - *Animal Testing Alternatives
MH  - Animals
MH  - Cell Differentiation
MH  - Cell Movement
MH  - Cell Proliferation
MH  - Cell Survival
MH  - Cells, Cultured
MH  - *High-Throughput Screening Assays
MH  - Humans
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neural Stem Cells/*cytology/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Reactive Oxygen Species/metabolism
MH  - Toxicity Tests/*methods
EDAT- 2012/05/15 06:00
MHDA- 2013/01/05 06:00
CRDT- 2012/05/15 06:00
PHST- 2011/12/02 00:00 [received]
PHST- 2012/04/19 00:00 [revised]
PHST- 2012/04/24 00:00 [accepted]
PHST- 2012/05/15 06:00 [entrez]
PHST- 2012/05/15 06:00 [pubmed]
PHST- 2013/01/05 06:00 [medline]
AID - S0887-2333(12)00130-0 [pii]
AID - 10.1016/j.tiv.2012.04.025 [doi]
PST - ppublish
SO  - Toxicol In Vitro. 2012 Sep;26(6):993-1000. doi: 10.1016/j.tiv.2012.04.025. Epub
      2012 May 2.


PMID- 22579478
OWN - NLM
STAT- MEDLINE
DCOM- 20121128
LR  - 20211021
IS  - 1873-3492 (Electronic)
IS  - 0009-8981 (Linking)
VI  - 413
IP  - 19-20
DP  - 2012 Oct 9
TI  - The evolution of biobanking best practices.
PG  - 1569-75
LID - 10.1016/j.cca.2012.04.030 [doi]
AB  - Biobanks and biospecimens are critical components for many areas of clinical and 
      basic research. The quality of biospecimens and associated data must be
      consistent and collected according to standardized methods in order to prevent
      spurious analytical results that can lead to artifacts being interpreted as valid
      findings. A number of international institutions have taken the initiative to
      develop and publish best practices, which include technical recommendations for
      handling biospecimens as well as recommendations for ethical and regulatory
      practices in biobanking. These sources of guidance have been useful in raising
      the overall consistency and quality of research involving biospecimens. However, 
      the lack of international harmonization, uneven adoption, and insufficient
      oversight of best practices are preventing further improvements in biospecimen
      quality and coordination among collaborators and biobanking networks. In contrast
      to the more straightforward technical and management issues, ethical and
      regulatory practices often involve issues that are more controversial and
      difficult to standardize.
CI  - Published by Elsevier B.V.
FAU - Vaught, Jim
AU  - Vaught J
AD  - Office of Biorepositories and Biospecimen Research, National Cancer Institute,
      National Institutes of Health, Department of Health and Human Services, 11400
      Rockville Pike, Bethesda, MD 20892, USA. vaughtj@mail.nih.gov
FAU - Lockhart, Nicole C
AU  - Lockhart NC
LA  - eng
GR  - Z99 CA999999/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20120503
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
SB  - IM
MH  - Biological Specimen Banks/ethics/*organization & administration
MH  - Humans
MH  - Informed Consent/ethics
MH  - International Cooperation
MH  - Practice Guidelines as Topic
MH  - Quality Control
MH  - Specimen Handling/methods/*standards
PMC - PMC3409343
MID - NIHMS375080
EDAT- 2012/05/15 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/05/15 06:00
PHST- 2012/03/17 00:00 [received]
PHST- 2012/04/28 00:00 [revised]
PHST- 2012/04/29 00:00 [accepted]
PHST- 2012/05/15 06:00 [entrez]
PHST- 2012/05/15 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - S0009-8981(12)00221-5 [pii]
AID - 10.1016/j.cca.2012.04.030 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2012 Oct 9;413(19-20):1569-75. doi: 10.1016/j.cca.2012.04.030.
      Epub 2012 May 3.


PMID- 22579415
OWN - NLM
STAT- MEDLINE
DCOM- 20121009
LR  - 20181201
IS  - 1578-1860 (Electronic)
IS  - 0014-2565 (Linking)
VI  - 212
IP  - 6
DP  - 2012 Jun
TI  - [Infections in elderly patients: is it a science, economy, sociology or ethics?].
PG  - 292-4
LID - 10.1016/j.rce.2012.03.012 [doi]
FAU - Payeras, A
AU  - Payeras A
LA  - spa
PT  - Editorial
PT  - Comment
TT  - Infecciones en pacientes de edad avanzada: inverted question markciencia,
      economia, sociologia o etica?
DEP - 20120510
PL  - Spain
TA  - Rev Clin Esp
JT  - Revista clinica espanola
JID - 8608576
SB  - IM
CON - Rev Clin Esp. 2012 Jun;212(6):273-80. PMID: 22520154
MH  - *Bacteremia
MH  - Female
MH  - Humans
MH  - Male
EDAT- 2012/05/15 06:00
MHDA- 2012/10/10 06:00
CRDT- 2012/05/15 06:00
PHST- 2012/03/04 00:00 [received]
PHST- 2012/03/13 00:00 [accepted]
PHST- 2012/05/15 06:00 [entrez]
PHST- 2012/05/15 06:00 [pubmed]
PHST- 2012/10/10 06:00 [medline]
AID - S0014-2565(12)00151-8 [pii]
AID - 10.1016/j.rce.2012.03.012 [doi]
PST - ppublish
SO  - Rev Clin Esp. 2012 Jun;212(6):292-4. doi: 10.1016/j.rce.2012.03.012. Epub 2012
      May 10.


PMID- 22577965
OWN - NLM
STAT- MEDLINE
DCOM- 20121126
LR  - 20220316
IS  - 1471-2288 (Electronic)
IS  - 1471-2288 (Linking)
VI  - 12
DP  - 2012 May 11
TI  - Bridging knowledge translation gap in health in developing countries: visibility,
      impact and publishing standards in journals from the Eastern Mediterranean.
PG  - 66
LID - 10.1186/1471-2288-12-66 [doi]
AB  - BACKGROUND: Local and regional scientific journals are important factors in
      bridging gaps in health knowledge translation in low-and middle-income countries.
      We assessed indexing, citations and publishing standards of journals from the
      Eastern Mediterranean region. METHODS: For journals from 22 countries in the
      collection of the Index Medicus for the Eastern Mediterranean Region (IMEMR), we 
      analyzed indexing in bibliographical databases and citations during 2006-2009 to 
      published items in 2006 in Web of Science (WoS) and SCOPUS. Adherence to
      editorial and publishing standards was assessed using a special checklist.
      RESULTS: Out of 419 journals in IMEMR, 19 were indexed in MEDLINE, 23 in WoS and 
      46 in SCOPUS. Their impact factors ranged from 0.016 to 1.417. For a subset of
      175 journals with available tables of contents from 2006, articles published in
      2006 from 93 journals received 2068 citations in SCOPUS (23.5% self-citations)
      and articles in 86 journals received 1579 citations in WoS (24.3% self-citations)
      during 2006-2009. Citations to articles came mostly from outside of the Eastern
      Mediterranean region (76.8% in WoS and 75.4% in SCOPUS). Articles receiving
      highest number of citations presented topics specific for the region. Many
      journals did not follow editorial and publishing standards, such addressing
      requirements about the patient's privacy rights (68.0% out of 244 analyzed),
      policy on managing conflicts of interest (66.4%), and ethical conduct in clinical
      and animal research (66.4%). CONCLUSION: Journals from the Eastern Mediterranean 
      are visible in and have impact on global scientific community. Coordinated effort
      of all stakeholders in journal publishing, including researchers, journal editors
      and owners, policy makers and citation databases, is needed to further promote
      local journals as windows to the research in the developing world and the doors
      for valuable regional research to the global scientific community.
FAU - Utrobicic, Ana
AU  - Utrobicic A
FAU - Chaudhry, Nauman
AU  - Chaudhry N
FAU - Ghaffar, Abdul
AU  - Ghaffar A
FAU - Marusic, Ana
AU  - Marusic A
LA  - eng
PT  - Letter
PT  - Research Support, Non-U.S. Gov't
DEP - 20120511
PL  - England
TA  - BMC Med Res Methodol
JT  - BMC medical research methodology
JID - 100968545
SB  - IM
MH  - Bibliometrics
MH  - *Developing Countries
MH  - Editorial Policies
MH  - Mediterranean Region
MH  - *Periodicals as Topic
MH  - Publishing/*standards
MH  - *Translational Research, Biomedical
PMC - PMC3430582
EDAT- 2012/05/15 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/05/15 06:00
PHST- 2011/08/22 00:00 [received]
PHST- 2012/04/18 00:00 [accepted]
PHST- 2012/05/15 06:00 [entrez]
PHST- 2012/05/15 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 1471-2288-12-66 [pii]
AID - 10.1186/1471-2288-12-66 [doi]
PST - epublish
SO  - BMC Med Res Methodol. 2012 May 11;12:66. doi: 10.1186/1471-2288-12-66.


PMID- 22577911
OWN - NLM
STAT- MEDLINE
DCOM- 20120622
LR  - 20220331
IS  - 0310-057X (Print)
IS  - 0310-057X (Linking)
VI  - 40
IP  - 3
DP  - 2012 May
TI  - Cyanoacrylate tissue adhesives - effective securement technique for intravascular
      catheters: in vitro testing of safety and feasibility.
PG  - 460-6
AB  - Partial or complete dislodgement of intravascular catheters remains a significant
      problem in hospitals despite current securement methods. Cyanoacrylate tissue
      adhesives (TA) are used to close skin wounds as an alternative to sutures. These 
      adhesives have high mechanical strength and can remain in situ for several days. 
      This study investigated in vitro use of TAs in securing intravascular catheters
      (IVC). We compared two adhesives for interaction with IVC material, comparing
      skin glues with current securement methods in terms of their ability to prevent
      IVC dislodgement and inhibit microbial growth. Two TAs (Dermabond, Ethicon Inc.
      and Histoacryl, B. Braun) and three removal agents (Remove, paraffin and acetone)
      were tested for interaction with IVC material by use of tensile testing. TAs were
      also compared against two polyurethane (standard and bordered) dressings
      (Tegaderm 1624 and 1633, 3M Australia Pty Ltd) and an external stabilisation
      device (Statlock, Bard Medical, Covington) against control (unsecured IVCs) for
      ability to prevent pull-out of 16 G peripheral IVCs from newborn fresh porcine
      skin. Agar media containing pH-sensitive dye was used to assess antimicrobial
      properties of TAs and polyurethane dressings to inhibit growth of Staphylococcus 
      aureus and Staphylococcus epidermidis. Neither TA weakened the IVCs (P >0.05). Of
      removal agents, only acetone was associated with a significant decrease in IVC
      strength (P <0.05). Both TAs and Statlock significantly increased the pull-out
      force (P <0.01). TA was quick and easy to apply to IVCs, with no irritation or
      skin damage noted on removal and no bacterial colony growth under either TA.
FAU - Simonova, G
AU  - Simonova G
AD  - Prince Charles Hospital, Brisbane, Queensland, Australia. g.simonova@uq.edu.au
FAU - Rickard, C M
AU  - Rickard CM
FAU - Dunster, K R
AU  - Dunster KR
FAU - Smyth, D J
AU  - Smyth DJ
FAU - McMillan, D
AU  - McMillan D
FAU - Fraser, J F
AU  - Fraser JF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Anaesth Intensive Care
JT  - Anaesthesia and intensive care
JID - 0342017
RN  - 0 (Cyanoacrylates)
RN  - 0 (Polyurethanes)
RN  - 0 (Solvents)
RN  - 0 (Tissue Adhesives)
RN  - 1364PS73AF (Acetone)
RN  - 8002-74-2 (Paraffin)
SB  - IM
MH  - Acetone
MH  - Animals
MH  - Animals, Newborn
MH  - Bacteria/growth & development
MH  - Bandages
MH  - Catheterization, Peripheral/adverse effects/instrumentation/*methods
MH  - *Catheters
MH  - *Cyanoacrylates/adverse effects
MH  - Feasibility Studies
MH  - Materials Testing
MH  - Paraffin
MH  - Patient Safety
MH  - Polyurethanes
MH  - Skin/drug effects/microbiology
MH  - Solvents
MH  - Staphylococcus aureus/drug effects
MH  - Staphylococcus epidermidis/drug effects
MH  - Swine
MH  - *Tissue Adhesives/adverse effects
EDAT- 2012/05/15 06:00
MHDA- 2012/06/23 06:00
CRDT- 2012/05/15 06:00
PHST- 2012/05/15 06:00 [entrez]
PHST- 2012/05/15 06:00 [pubmed]
PHST- 2012/06/23 06:00 [medline]
AID - 20120030 [pii]
AID - 10.1177/0310057X1204000311 [doi]
PST - ppublish
SO  - Anaesth Intensive Care. 2012 May;40(3):460-6. doi: 10.1177/0310057X1204000311.


PMID- 22577814
OWN - NLM
STAT- MEDLINE
DCOM- 20120905
LR  - 20120514
IS  - 1557-9034 (Electronic)
IS  - 1092-6429 (Linking)
VI  - 22
IP  - 4
DP  - 2012 May
TI  - A safe technique of thoracoscopic clipping of patent ductus arteriosus in
      children.
PG  - 422-4
LID - 10.1089/lap.2011.0454 [doi]
AB  - AIM: To present a modified and safe technique of thoracoscopic clipping of patent
      ductus arteriosus (PDA) in children and its early outcomes. PATIENTS AND METHODS:
      Patients are anesthetized, ventilated via single-lung ventilation, and placed in 
      a right lateral position. The surgeon and the assistant stand at the patient's
      feet, and a monitor is placed at the patient's head. The ductus is pulled forward
      with a Vicryl((R)) (Ethicon) thread and clipped completely. RESULTS: From May
      2010 to February 2011, 58 patients with PDA (27 boys and 31 girls) were operated 
      on using the same technique. Patients' ages varied from 8 days to 36 months. Mean
      weight of patients was 5.9+/-2.8 kg (range, 2.1-10 kg). Mean operative time was
      33+/-12 minutes (range, 15-90 minutes). There were no intraoperative
      complications. Postoperative complications occurred in 2 patients: 1 patient
      developed a pneumothorax, and 1 patient had pleural effusion. Mean postoperative 
      stay was 4.1+/-2.1 days for patients >3 months old and 11.9+/-8.4 days for
      patients </=3 months old. No injuries of recurrent laryngeal nerve occurred in
      any patients, and there were no residual shunts in any patients 3-6 months after 
      discharge. CONCLUSION: A modified technique of thoracoscopic closure is a safe
      and effective procedure for PDA in children.
FAU - Liem, Nguyen Thanh
AU  - Liem NT
AD  - Department of Pediatric Surgery, National Hospital of Pediatrics, Hanoi, Vietnam.
      liemnhp@hotmail.com
FAU - Tuan, Tu Manh
AU  - Tuan TM
FAU - Linh, Nguyen Van
AU  - Linh NV
LA  - eng
PT  - Journal Article
PT  - Technical Report
PL  - United States
TA  - J Laparoendosc Adv Surg Tech A
JT  - Journal of laparoendoscopic & advanced surgical techniques. Part A
JID - 9706293
SB  - IM
MH  - Child, Preschool
MH  - Ductus Arteriosus, Patent/*surgery
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Length of Stay
MH  - Male
MH  - Thoracoscopy/*methods
MH  - Treatment Outcome
EDAT- 2012/05/15 06:00
MHDA- 2012/09/06 06:00
CRDT- 2012/05/15 06:00
PHST- 2012/05/15 06:00 [entrez]
PHST- 2012/05/15 06:00 [pubmed]
PHST- 2012/09/06 06:00 [medline]
AID - 10.1089/lap.2011.0454 [doi]
PST - ppublish
SO  - J Laparoendosc Adv Surg Tech A. 2012 May;22(4):422-4. doi: 10.1089/lap.2011.0454.


PMID- 25192141
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 0890-9091 (Print)
IS  - 0890-9091 (Linking)
VI  - 26
IP  - 5
DP  - 2012 May 15
TI  - Genetic testing in cancer: ethical issues.
LID - 168242 [pii]
FAU - Tenner, Laura
AU  - Tenner L
FAU - Helft, Paul R
AU  - Helft PR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Oncology (Williston Park)
JT  - Oncology (Williston Park, N.Y.)
JID - 8712059
SB  - IM
EDAT- 2012/05/15 00:00
MHDA- 2012/05/15 00:01
CRDT- 2014/09/06 06:00
PHST- 2014/09/06 06:00 [entrez]
PHST- 2012/05/15 00:00 [pubmed]
PHST- 2012/05/15 00:01 [medline]
AID - 168242 [pii]
PST - ppublish
SO  - Oncology (Williston Park). 2012 May 15;26(5). pii: 168242.


PMID- 22577530
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 2090-133X (Electronic)
IS  - 2090-1321 (Linking)
VI  - 2012
DP  - 2012
TI  - Spiritually integrated treatment of depression: a conceptual framework.
PG  - 124370
LID - 10.1155/2012/124370 [doi]
AB  - Many studies have found an inverse correlation between religious/spiritual
      involvement and depression. Yet several obstacles impede spiritually integrated
      treatment of depressed individuals. These include specialization and
      fragmentation of care, inexperience of clinicians and spiritual care providers,
      ideological bias, boundary and ethical concerns, and the lack of an accepted
      conceptual framework for integrated treatment. Here I suggest a framework for
      approaching these obstacles, constructed from a unified view of human experience 
      (having emotional, existential, and spiritual dimensions); spirituality seen as a
      response to existential concerns (in domains such as identity, hope,
      meaning/purpose, morality, and autonomy in relation to authority, which are
      frequently distorted and amplified in depression); a rationale for locating
      spiritually oriented approaches within a clinician's assessment, formulation, and
      treatment plan; and recognition of the challenges and potential pitfalls of
      integrated treatment.
FAU - Peteet, John R
AU  - Peteet JR
AD  - Department of Psychosocial Oncology and Palliative Care, Dana-Farber Cancer
      Institute and Brigham and Women's Hospital, Boston, MA 02115, USA.
LA  - eng
PT  - Journal Article
DEP - 20120419
PL  - United States
TA  - Depress Res Treat
JT  - Depression research and treatment
JID - 101546752
PMC - PMC3345211
EDAT- 2012/05/12 06:00
MHDA- 2012/05/12 06:01
CRDT- 2012/05/12 06:00
PHST- 2012/01/21 00:00 [received]
PHST- 2012/03/04 00:00 [accepted]
PHST- 2012/05/12 06:00 [entrez]
PHST- 2012/05/12 06:00 [pubmed]
PHST- 2012/05/12 06:01 [medline]
AID - 10.1155/2012/124370 [doi]
PST - ppublish
SO  - Depress Res Treat. 2012;2012:124370. doi: 10.1155/2012/124370. Epub 2012 Apr 19.


PMID- 22577469
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1748-2631 (Electronic)
IS  - 1748-2623 (Linking)
VI  - 7
DP  - 2012
TI  - Care of the old-A matter of ethics, organization and relationships.
LID - 10.3402/qhw.v7i0.9684 [doi]
AB  - The world stands on the threshold of a demographic revolution called global
      ageing. According to the World Health Organization (WHO), the population aged 60 
      and over is expected to increase from today's 650 million to an estimated 2
      billion by 2050. Alongside demographic changes, dramatic changes can also be
      observed in older people's services. The shift has resulted in reduced government
      spending on caring for ill and frail older people in health care. Today, many
      governments have developed strategies to keep older people living well in their
      private home for as long as possible and have replaced long-term care
      institutions with residential homes. The aim of this study was to illuminate the 
      meaning of caring for older people as experienced by health care students and
      professionals working in this field. Interviews were carried out with 17 women
      and one man, aged 21-65 years; six were Registered Nurses (RN), six were Enrolled
      Nurses (EN) and six were nursing students. The interviews were analyzed with a
      phenomenological hermeneutical approach and provided three themes and eight
      sub-themes: Ethical moral self with sub-themes "meeting the needs of the old",
      "pliability towards the old", and "difficulties in meeting aggressiveness";
      Organizational and co-workers ethical moral actions with sub-themes, "co-workers 
      who are offensive", and "supportive and non-supportive leaders": The relation
      with the old persons and their relatives with sub-themes "fellowship and
      closeness in the relation", "uncertainty and fear in the relation", and, "demands
      from the older persons' close relatives".
FAU - Fagerberg, Ingegerd
AU  - Fagerberg I
AD  - Department of Health Care Sciences, Ersta Skondal University College, Stockholm, 
      Sweden.
FAU - Engstrom, Gabriella
AU  - Engstrom G
LA  - eng
PT  - Journal Article
DEP - 20120508
PL  - United States
TA  - Int J Qual Stud Health Well-being
JT  - International journal of qualitative studies on health and well-being
JID - 101256506
PMC - PMC3349146
OTO - NOTNLM
OT  - Care of the old
OT  - care relation
OT  - ethics
OT  - nurses
OT  - organization
OT  - phenomenological hermeneutics
OT  - students
EDAT- 2012/05/12 06:00
MHDA- 2012/05/12 06:01
CRDT- 2012/05/12 06:00
PHST- 2012/04/05 00:00 [accepted]
PHST- 2012/05/12 06:00 [entrez]
PHST- 2012/05/12 06:00 [pubmed]
PHST- 2012/05/12 06:01 [medline]
AID - 10.3402/qhw.v7i0.9684 [doi]
AID - QHW-7-9684 [pii]
PST - ppublish
SO  - Int J Qual Stud Health Well-being. 2012;7. pii: QHW-7-9684. doi:
      10.3402/qhw.v7i0.9684. Epub 2012 May 8.


PMID- 22577193
OWN - NLM
STAT- MEDLINE
DCOM- 20120703
LR  - 20181023
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 344
DP  - 2012 May 10
TI  - Human rights group attacks Israeli government for violating medical ethics in its
      treatment of hunger strikers.
PG  - e3329
LID - 10.1136/bmj.e3329 [doi]
LID - bmj.e3329 [pii]
FAU - Traubmann, Tamara
AU  - Traubmann T
LA  - eng
PT  - News
DEP - 20120510
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
SB  - IM
MH  - Dissent and Disputes
MH  - *Ethics, Medical
MH  - Fasting
MH  - *Human Rights
MH  - Humans
MH  - Israel
MH  - Prisoners/*legislation & jurisprudence
EDAT- 2012/05/12 06:00
MHDA- 2012/07/04 06:00
CRDT- 2012/05/12 06:00
PHST- 2012/05/12 06:00 [entrez]
PHST- 2012/05/12 06:00 [pubmed]
PHST- 2012/07/04 06:00 [medline]
AID - 10.1136/bmj.e3329 [doi]
PST - epublish
SO  - BMJ. 2012 May 10;344:e3329. doi: 10.1136/bmj.e3329.


PMID- 22577179
OWN - NLM
STAT- MEDLINE
DCOM- 20120827
LR  - 20120910
IS  - 1471-8391 (Electronic)
IS  - 0007-1420 (Linking)
VI  - 102
DP  - 2012 Jun
TI  - A review and update on the current status of stem cell therapy and the retina.
PG  - 133-46
LID - 10.1093/bmb/lds013 [doi]
AB  - INTRODUCTION OR BACKGROUND: Many diseases of the retina result in irreversible
      visual loss. Stem cell (SC) therapy is a rapidly developing field and represents 
      a novel approach to replace non-functioning neuro-retinal cells. SOURCES OF DATA:
      A systematic computerized literature search was conducted on PubMed
      (http://www.ncbi.nlm.nih.gov/pubmed/). AREAS OF AGREEMENT: The use of stem cells 
      (SCs) in animal models of retinal diseases has resulted in improvement in visual 
      function and performance. SC therapy represents an exciting prospect in restoring
      vision. Areas of controversy The use of human embryonic SCs raises ethical
      concerns. GROWING POINTS: Human trials using SCs in retinal diseases have
      recently been approved. AREAS TIMELY FOR DEVELOPING RESEARCH: The success of SCs 
      in retinal therapy depends not only on implanted cell survival, but also on how
      well SCs migrate, integrate and form synapses. Further research will be needed to
      overcome these hurdles.
FAU - Ong, J M
AU  - Ong JM
AD  - National Institute of Health Research, Biomedical Research Centre, Moorfields Eye
      Hospital, London, UK. jongmin@doctors.org.uk
FAU - da Cruz, L
AU  - da Cruz L
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120509
PL  - England
TA  - Br Med Bull
JT  - British medical bulletin
JID - 0376542
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - Humans
MH  - Photoreceptor Cells, Vertebrate/transplantation
MH  - Retinal Diseases/*therapy
MH  - Retinal Ganglion Cells/transplantation
MH  - Retinal Pigment Epithelium/transplantation
MH  - Stem Cell Transplantation/*methods
EDAT- 2012/05/12 06:00
MHDA- 2012/08/28 06:00
CRDT- 2012/05/12 06:00
PHST- 2012/05/12 06:00 [entrez]
PHST- 2012/05/12 06:00 [pubmed]
PHST- 2012/08/28 06:00 [medline]
AID - lds013 [pii]
AID - 10.1093/bmb/lds013 [doi]
PST - ppublish
SO  - Br Med Bull. 2012 Jun;102:133-46. doi: 10.1093/bmb/lds013. Epub 2012 May 9.


PMID- 22576990
OWN - NLM
STAT- MEDLINE
DCOM- 20121105
LR  - 20211021
IS  - 1432-055X (Electronic)
IS  - 0003-2417 (Linking)
VI  - 61
IP  - 6
DP  - 2012 Jun
TI  - [Between patient autonomy and the ethics of care : difficult end-of-life
      decision-making in intensive care].
PG  - 521-8
LID - 10.1007/s00101-012-2017-1 [doi]
AB  - The article illustrates the ethical principles and the legal context of
      end-of-life decision-making in the intensive care unit (ICU). After a long period
      of preference for medical paternalism, patient autonomy has now developed into
      the standard for medical decision-making. Medical interventions are justified by 
      medical indications and patient consent. A competent patient may make a decision 
      which is unreasonable from the physician's view. A mentally incompetent patient
      will can be explored by studying the written anticipated advance directive in
      which the patient has formulated value priorities. The binding character of
      patient advance directives was regulated in German law in 2009; the decision has 
      to be made in a dialogue between the physician and the proxy. A judgment of the
      German High Court in 2010 confirmed that even an active withdrawal of therapeutic
      measures, such as mechanical ventilation is legal.
FAU - Erbguth, F
AU  - Erbguth F
AD  - Klinik fur Neurologie, Klinikum Nurnberg, Breslauer Str. 201, 90471, Nurnberg,
      Deutschland. erbguth@klinikum-nuernberg.de
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Zwischen Selbstbestimmung und Fursorge : Schwierige intensivmedizinische
      Entscheidungen am Lebensende.
PL  - Germany
TA  - Anaesthesist
JT  - Der Anaesthesist
JID - 0370525
SB  - IM
MH  - Advance Directives
MH  - Attitude of Health Personnel
MH  - Critical Care/*ethics
MH  - Germany
MH  - Humans
MH  - Informed Consent
MH  - *Personal Autonomy
MH  - Presumed Consent
MH  - Prognosis
MH  - Proxy
MH  - Terminal Care/*ethics/legislation & jurisprudence
MH  - Withholding Treatment/ethics/legislation & jurisprudence
EDAT- 2012/05/12 06:00
MHDA- 2012/11/06 06:00
CRDT- 2012/05/12 06:00
PHST- 2012/05/12 06:00 [entrez]
PHST- 2012/05/12 06:00 [pubmed]
PHST- 2012/11/06 06:00 [medline]
AID - 10.1007/s00101-012-2017-1 [doi]
PST - ppublish
SO  - Anaesthesist. 2012 Jun;61(6):521-8. doi: 10.1007/s00101-012-2017-1.


PMID- 22576961
OWN - NLM
STAT- MEDLINE
DCOM- 20121109
LR  - 20211021
IS  - 1613-7671 (Electronic)
IS  - 0043-5325 (Linking)
VI  - 124
IP  - 9-10
DP  - 2012 May
TI  - Heparin-induced effects of prothrombin complex concentrates in
      thromboelastometry.
PG  - 320-5
LID - 10.1007/s00508-012-0171-8 [doi]
AB  - BACKGROUND: Prothrombin complex concentrates (PCC) are currently used to treat
      congenital or acquired coagulation factor deficiency. In case of serious bleeding
      caused by new oral anticoagulant agents, reversing treatment with PCC is under
      debate. PCC preparations mostly contain heparin to prevent thromboembolic events.
      In factor VIII and IX deficient plasma, Takeyama et al. observed in vitro a
      heparin effect at appropriate concentrations of PCCs. The aim of the present
      experiment was to investigate the heparin effect of four factor-PCC at clinically
      relevant concentrations in whole blood. In an in vitro experiment, we compared
      the PCC preparation used in the experiments of Takeyama with a high heparin
      content to a new heparin-free PCC preparation. METHOD: After ethics committee
      approval and written informed consent, the citrated whole blood was obtained from
      ten healthy volunteers. We tested heparin-containing Prothromplex((R)) and
      heparin-free Cofact((R)) at concentrations of 0.31, 0.63, and 1.25 IU/ml.
      Protamine was added to another set of samples (1:1 heparin:protamine). We used
      the NATEM test in the rotational thromboelastometer ROTEM((R)). RESULTS: In the
      heparin PCC preparation, we observed a significant (p < 0.001)
      concentration-dependent prolongation in CT and CFT, even at the lowest
      concentration. MCF was also significantly reduced. The heparin effect was
      reversible by protamine. The heparin-free PCC did not affect the onset of
      coagulation. The interpretation of the alpha-angle showed no increased thrombus
      formation in heparin-free PCC preparation. CONCLUSION: Our results extend the
      report of Takeyama et al. At clinically relevant PCC concentrations, the heparin 
      effect was significant in thromboelastometry. The heparin content of PCCs should 
      be considered in clinical routine.
FAU - Scharbert, Gisela
AU  - Scharbert G
AD  - Department of Special Anesthesiology and Pain Management, General Intensive Care 
      and Pain Control, Vienna Medical University, 1090, Vienna, Waehringer Guertel
      18-20, Austria. gisela.scharbert@meduniwien.ac.at
FAU - Thaler, Ulrich
AU  - Thaler U
FAU - Weilnbock, Christoph
AU  - Weilnbock C
FAU - Wetzel, Leonore
AU  - Wetzel L
FAU - Kozek-Langenecker, Sibylle
AU  - Kozek-Langenecker S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120511
PL  - Austria
TA  - Wien Klin Wochenschr
JT  - Wiener klinische Wochenschrift
JID - 21620870R
RN  - 0 (Blood Coagulation Factors)
RN  - 37224-63-8 (prothrombin complex concentrates)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Blood Coagulation/*drug effects/*physiology
MH  - Blood Coagulation Factors/*administration & dosage
MH  - Dose-Response Relationship, Drug
MH  - Drug Interactions
MH  - Heparin/*administration & dosage
MH  - Humans
MH  - *Thrombelastography
EDAT- 2012/05/12 06:00
MHDA- 2012/11/10 06:00
CRDT- 2012/05/12 06:00
PHST- 2011/11/08 00:00 [received]
PHST- 2012/04/15 00:00 [accepted]
PHST- 2012/05/12 06:00 [entrez]
PHST- 2012/05/12 06:00 [pubmed]
PHST- 2012/11/10 06:00 [medline]
AID - 10.1007/s00508-012-0171-8 [doi]
PST - ppublish
SO  - Wien Klin Wochenschr. 2012 May;124(9-10):320-5. doi: 10.1007/s00508-012-0171-8.
      Epub 2012 May 11.


PMID- 22576879
OWN - NLM
STAT- MEDLINE
DCOM- 20120717
LR  - 20131121
IS  - 1096-9888 (Electronic)
IS  - 1076-5174 (Linking)
VI  - 47
IP  - 5
DP  - 2012 May
TI  - Perforated dried blood spot accurate microsampling: the concept and its
      applications in toxicokinetic sample collection.
PG  - 655-67
LID - 10.1002/jms.3015 [doi]
AB  - Dried blood spot (DBS) sampling has gained considerable interest as a
      microsampling technique to support drug discovery and development owing to its
      enormous ethical and practical benefits. Quantitative determinations of drugs
      and/or their metabolites collected in DBS matrix in its current format, however, 
      have encountered technical challenges and regulatory uncertainty. The challenges 
      of DBS bioanalysis are largely ascribed to the way how samples are collected and 
      analyzed. Currently, an uncontrolled amount of a blood sample, e.g. 20 microl, is
      collected per time point per sample and spotted onto cellulose paper.
      Quantitation is based on removal of a fixed area of the DBS sample, resulting in 
      sample waste, a need for mechanical punching and concomitant potential punching
      carryover, uncertainty in recovery assessment and the adverse impact of
      hematocrit on accurate quantitation. Here, we describe the concept and
      applications of a novel concept, namely perforated dried blood spot (PDBS), for
      accurate microsampling that addresses previous challenges. Advantages of PDBS are
      enumerated and compared with conventional DBS in the context of microsampling and
      liquid chromatography tandem mass spectrometry bioanalysis. Two approaches for
      accurate microsampling of a small volume of blood (5 microl) are proposed and
      demonstrated, i.e. Microsafe(R) pipettes and the Drummond incremental pipette.
      Two online sample enrichment techniques to enhance liquid chromatography tandem
      mass spectrometry sensitivity for microsampling bioanalysis are discussed. The
      PDBS concept was successfully applied for accurate sample collection (5 microl)
      in a toxicokinetic study in rats given a single oral gavage dose of
      acetaminophen. Perspectives on bioanalytical method validation for regulated
      DBS/PDBS microsampling are also presented.
CI  - Copyright (c) 2012 John Wiley & Sons, Ltd.
FAU - Li, Fumin
AU  - Li F
AD  - Covance Laboratories, Inc, Bioanalytical Chemistry, 3301 Kinsman Boulevard,
      Madison, Wisconsin 53704, USA. fumin.li@covance.com
FAU - Ploch, Stephen
AU  - Ploch S
FAU - Fast, Douglas
AU  - Fast D
FAU - Michael, Steve
AU  - Michael S
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Mass Spectrom
JT  - Journal of mass spectrometry : JMS
JID - 9504818
RN  - 0 (2-Pyridinylmethylsulfinylbenzimidazoles)
RN  - 0K5C5T2QPG (Lansoprazole)
RN  - 362O9ITL9D (Acetaminophen)
SB  - IM
MH  - 2-Pyridinylmethylsulfinylbenzimidazoles/blood/pharmacokinetics
MH  - Acetaminophen/blood/pharmacokinetics
MH  - Animals
MH  - Blood Specimen Collection/instrumentation/methods
MH  - Chromatography, Liquid/methods
MH  - Dried Blood Spot Testing/*methods
MH  - Humans
MH  - Lansoprazole
MH  - Male
MH  - *Pharmacokinetics
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reproducibility of Results
MH  - Tandem Mass Spectrometry/methods
MH  - Technology, Pharmaceutical/instrumentation/methods
EDAT- 2012/05/12 06:00
MHDA- 2012/07/18 06:00
CRDT- 2012/05/12 06:00
PHST- 2012/05/12 06:00 [entrez]
PHST- 2012/05/12 06:00 [pubmed]
PHST- 2012/07/18 06:00 [medline]
AID - 10.1002/jms.3015 [doi]
PST - ppublish
SO  - J Mass Spectrom. 2012 May;47(5):655-67. doi: 10.1002/jms.3015.


PMID- 22576536
OWN - NLM
STAT- MEDLINE
DCOM- 20160423
LR  - 20190911
IS  - 0080-6234 (Print)
IS  - 0080-6234 (Linking)
VI  - 46
IP  - 2
DP  - 2012 Apr
TI  - [Cognitive alterations of the elderly in home settings and the attitudes of
      children towards aging].
PG  - 335-41
LID - S0080-62342012000200010 [pii]
AB  - Children develop attitudes towards aging from birth and are influenced by
      everyday factors. The objective of this study was to evaluate attitudes towards
      aging of children living with elderly individuals with and without cognitive
      changes. Home interviews were performed with 54 children from five Family Health 
      Units, 25 of whom lived with seniors with cognitive changes (group 1), and 29
      living with seniors without cognitive changes (group 2). All ethical precautions 
      were observed. The Scale for Children's Attitudes Towards Aging was used. The
      mean scores obtained were 1.66 (group 1) and 1.52 (group 2). One point
      represented the most positive possible score, and three points the most negative.
      The comparison between groups, cognition domains, and social relationships
      presented significant rates, showing that children living with seniors with
      cognitive changes have more negative attitudes in these domains. Primary
      healthcare professionals should pay close attention to multigenerational families
      and invest in their education.
FAU - Luchesi, Bruna Moretti
AU  - Luchesi BM
AD  - Universidade Federal de Sao Carlos, Sao Carlos, SP, Brasil.
      bruna_luchesi@yahoo.com.br
FAU - Pavarini, Sofia Cristina Iost
AU  - Pavarini SC
FAU - Viana, Aline Silveira
AU  - Viana AS
LA  - por
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
TT  - Alteracoes cognitivas de idosos no contexto domiciliar e atitudes de criancas em 
      relacao a velhice.
PL  - Brazil
TA  - Rev Esc Enferm USP
JT  - Revista da Escola de Enfermagem da U S P
JID - 0242726
MH  - Aged
MH  - *Aging
MH  - *Attitude
MH  - Child
MH  - Cognition
MH  - Family Health
MH  - Homes for the Aged
MH  - Humans
EDAT- 2012/05/12 06:00
MHDA- 2016/04/24 06:00
CRDT- 2012/05/12 06:00
PHST- 2010/12/15 00:00 [received]
PHST- 2011/05/30 00:00 [accepted]
PHST- 2012/05/12 06:00 [entrez]
PHST- 2012/05/12 06:00 [pubmed]
PHST- 2016/04/24 06:00 [medline]
AID - S0080-62342012000200010 [pii]
AID - 10.1590/s0080-62342012000200010 [doi]
PST - ppublish
SO  - Rev Esc Enferm USP. 2012 Apr;46(2):335-41. doi: 10.1590/s0080-62342012000200010.


PMID- 22576161
OWN - NLM
STAT- MEDLINE
DCOM- 20120719
LR  - 20120511
IS  - 1534-6080 (Electronic)
IS  - 0041-1337 (Linking)
VI  - 93
IP  - 10
DP  - 2012 May 27
TI  - Whose consent matters? Controlled donation after cardiac death and premortem
      organ-preserving measures.
PG  - 965-9
LID - 10.1097/TP.0b013e31824836fa [doi]
AB  - The goal of this overview is to discuss the ethics of premortem organ-protective 
      measures with the aim of improving donation outcome for the recipient. A
      literature review was undertaken to find out which such measures were implemented
      in published articles on controlled donation after cardiac death. We reviewed
      studies on controlled human organ donation after cardiac death that were
      published in PUBMED and EMBASE between 2000 and 2010. To fit the inclusion
      criteria, studies had to describe the procedures that took place before the
      donor's death. We found 35 studies that were undertaken in six countries.
      Twenty-one of these studies mentioned the use of premortem measures on the donor 
      that had the aim to improve the outcome of donation for the recipient. These
      measures illustrated a wide spectrum of invasiveness. The authors conclude that
      premortem measures have the potential to instrumentalize the organ donor and that
      they should be restricted to cases in which the donor wish is known-directly,
      through a donor card, or through a surrogate decision maker-and specific consent 
      to premortem procedures has been given. This specific consent should be required 
      at least until the general public is aware that premortem measures may be
      performed. If potential donors were informed about premortem measures as part of 
      a community information effort, for example, school curricula, and again when
      they signed their donor card, one might consider their consent to be truly
      informed and valid.
FAU - Bastami, Sohaila
AU  - Bastami S
FAU - Krones, Tanja
AU  - Krones T
FAU - Biller-Andorno, Nikola
AU  - Biller-Andorno N
LA  - eng
PT  - Editorial
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
SB  - IM
MH  - *Death
MH  - Humans
MH  - *Organ Preservation
MH  - Tissue and Organ Procurement/*ethics
EDAT- 2012/05/12 06:00
MHDA- 2012/07/20 06:00
CRDT- 2012/05/12 06:00
PHST- 2012/05/12 06:00 [entrez]
PHST- 2012/05/12 06:00 [pubmed]
PHST- 2012/07/20 06:00 [medline]
AID - 10.1097/TP.0b013e31824836fa [doi]
AID - 00007890-201205270-00001 [pii]
PST - ppublish
SO  - Transplantation. 2012 May 27;93(10):965-9. doi: 10.1097/TP.0b013e31824836fa.


PMID- 22575856
OWN - NLM
STAT- MEDLINE
DCOM- 20121220
LR  - 20210106
IS  - 1529-4242 (Electronic)
IS  - 0032-1052 (Linking)
VI  - 130
IP  - 3
DP  - 2012 Sep
TI  - Novel surgical technique for full face transplantation.
PG  - 549-555
LID - 10.1097/PRS.0b013e31825dc25c [doi]
AB  - BACKGROUND: Full face transplantation raises a new set of ethical concerns and
      technical difficulties when compared with partial face transplantation.
      Previously, it was thought that full face allografts must include bilateral
      superficial temporal and facial arteries, dictating the need for inclusion of
      donor parotid glands. This would lead to poor aesthetic outcomes and limit facial
      nerve coaptation to the level of the main trunk, which often results in
      synkinesias. The authors present a new approach to full facial allograft recovery
      based on blood supply from facial arteries alone. This approach eliminates the
      need to include parotid glands, enabling more distal coaptation of facial nerve
      branches and targeted innervation of effector muscles. The recovery can be
      reproducibly performed within 4 hours. METHODS: Three mock cadaver dissections
      and three full face transplantations were performed. RESULTS: Donor facial
      allografts were dissected in cranio-caudal and lateral-to-medial fashion.
      Individual facial nerve branches were cut medial to parotid glands and coapted to
      corresponding recipient nerve branches. With the exception of one parotid gland
      used to add bulk, parotids were generally not included in the allografts.
      Relevant sensory nerves were coapted. External carotid arteries were dissected,
      leaving only bilateral facial arteries as the primary arterial supply. All full
      facial allografts were well perfused immediately following transplantation and
      are surviving. CONCLUSIONS: The authors describe a new, simple, and reproducible 
      technique of full facial allograft recovery that allows perfusion using only
      bilateral facial arteries. Their technique follows critical principles of
      targeted sensory and motor nerve coaptation.
FAU - Pomahac, Bohdan
AU  - Pomahac B
AD  - Boston, Mass. From the Division of Plastic Surgery, Brigham and Women's Hospital 
      and Harvard Medical School, and the Harvard Combined Plastic Surgery Residency
      Program, Harvard Medical School.
FAU - Pribaz, Julian J
AU  - Pribaz JJ
FAU - Bueno, Ericka M
AU  - Bueno EM
FAU - Sisk, Geoffroy C
AU  - Sisk GC
FAU - Diaz-Siso, J Rodrigo
AU  - Diaz-Siso JR
FAU - Chandawarkar, Akash
AU  - Chandawarkar A
FAU - Westvik, Tormod S
AU  - Westvik TS
FAU - Malin, Edward W
AU  - Malin EW
FAU - Eriksson, Elof
AU  - Eriksson E
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Plast Reconstr Surg
JT  - Plastic and reconstructive surgery
JID - 1306050
SB  - IM
MH  - Anastomosis, Surgical/methods
MH  - Cadaver
MH  - Dissection
MH  - Face/anatomy & histology/*blood supply/*innervation/surgery
MH  - Facial Muscles/blood supply/innervation/surgery
MH  - Facial Transplantation/*methods
MH  - Humans
MH  - Surgical Flaps/*blood supply/*innervation
MH  - Suture Techniques
MH  - Transplantation, Homologous
EDAT- 2012/05/12 06:00
MHDA- 2012/12/21 06:00
CRDT- 2012/05/12 06:00
PHST- 2012/05/12 06:00 [entrez]
PHST- 2012/05/12 06:00 [pubmed]
PHST- 2012/12/21 06:00 [medline]
AID - 10.1097/PRS.0b013e31825dc25c [doi]
AID - 00006534-201209000-00010 [pii]
PST - ppublish
SO  - Plast Reconstr Surg. 2012 Sep;130(3):549-555. doi: 10.1097/PRS.0b013e31825dc25c.


PMID- 22575848
OWN - NLM
STAT- MEDLINE
DCOM- 20120718
LR  - 20120511
IS  - 1536-4798 (Electronic)
IS  - 0277-3740 (Linking)
VI  - 31
IP  - 6
DP  - 2012 Jun
TI  - Wedge resection and lamellar dissection for pellucid marginal degeneration.
PG  - 708-15
LID - 10.1097/ICO.0b013e31824000e3 [doi]
AB  - PURPOSE: To describe the use of crescentic corneal lamellar wedge resection and
      autolamellar dissection for the correction of pellucid marginal degeneration
      (PMD), and to assess its effectiveness in improving uncorrected visual acuity
      (UCVA), best-corrected visual acuity (BCVA), astigmatism, corneal topography, and
      contact lens or spectacle tolerability. METHODS: The setting was a specialist
      referral corneal surgery center, United Kingdom. A retrospective review was
      performed of all patients who underwent a corneal wedge resection for PMD at our 
      institutions. All patients had progressive deterioration of BCVA, increased
      astigmatism, and intolerance to contact lens wear. The irregular corneal shape
      with ectasia was detected clinically and confirmed by Orbscan tomography. A
      crescentic wedge of ectatic corneal tissue was excised in each case, the extent
      of which was judged both clinically and by Orbscan. Complete host deep lamellar
      dissection (limbus to limbus) was performed in 3 cases and partial host lamellar 
      dissection in 3 cases to enable closure by mobilizing the host anterior lamellar 
      cornea. Mersilene 10-0 (Ethicon, Somerville, NJ) sutures were used and adjusted
      to achieve a 90-degree shift in the axis of astigmatism. RESULTS: Seven eyes of 6
      patients had wedge resections performed by 1 surgeon (S.M.D.). The patients were 
      followed for a mean of 10.7 months (SD, 9.2; range, 1-25 months). The eyes of
      patients with >1 month of follow-up had improved UCVA and BCVA. Four of 5 eyes of
      patients with >2 months of follow-up had a BCVA of 6/12 or better. Four patients 
      were able to manage with improved visual acuity in spectacles, and 1 patient
      chose to wear contact lenses to achieve 6/7.5. One patient with only 6 months of 
      follow-up had a UCVA of 6/7.5. The average reduction in keratometric cylinder for
      cases with >2 months of follow-up was 9.1 diopters (SD, 5.3; range, 3.1-16.3
      diopters). CONCLUSIONS: Corneal wedge resection with and without lamellar
      dissection is an effective surgical intervention for corneal ectasia in PMD and
      avoids allogeneic transplantation by way of a large penetrating or lamellar
      keratoplasty. The technique has a low intraoperative complication rate and gives 
      improved UCVA, BCVA, keratometric cylinder, and spectacle or contact lens
      tolerance.
FAU - Maccheron, Luke J
AU  - Maccheron LJ
AD  - Corneoplastic Unit and Eye Bank, Queen Victoria Hospital, East Grinstead, UK.
FAU - Daya, Sheraz M
AU  - Daya SM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cornea
JT  - Cornea
JID - 8216186
SB  - IM
MH  - Adult
MH  - Astigmatism/physiopathology
MH  - Corneal Diseases/diagnosis/*surgery
MH  - Corneal Topography
MH  - Dilatation, Pathologic/surgery
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Ophthalmologic Surgical Procedures
MH  - Retrospective Studies
MH  - Treatment Outcome
MH  - Visual Acuity/physiology
EDAT- 2012/05/12 06:00
MHDA- 2012/07/19 06:00
CRDT- 2012/05/12 06:00
PHST- 2012/05/12 06:00 [entrez]
PHST- 2012/05/12 06:00 [pubmed]
PHST- 2012/07/19 06:00 [medline]
AID - 10.1097/ICO.0b013e31824000e3 [doi]
AID - 00003226-201206000-00020 [pii]
PST - ppublish
SO  - Cornea. 2012 Jun;31(6):708-15. doi: 10.1097/ICO.0b013e31824000e3.


PMID- 22575142
OWN - NLM
STAT- MEDLINE
DCOM- 20140515
LR  - 20120511
IS  - 0254-6450 (Print)
IS  - 0254-6450 (Linking)
VI  - 33
IP  - 2
DP  - 2012 Feb
TI  - [Changes on secular growth among minority girls in China from 1985 to 2005].
PG  - 192-6
AB  - OBJECTIVE: To analyze the trend of secular growth among the minority girls in
      China from 1985 to 2005 in order to develop national and local intervention
      strategies and measures to improve their physical fitness and health. METHODS: A 
      total of 19 Chinese minority girls, including Mongolian, Hui, Zhuang, Korean,
      Tibetan, Miao, Buyi, Dong, Yao, Bai, Tujia, Hani, Dai, Lisu, Wa, Nakhi, Tu, Qiang
      and Salar were sampled from the 1985 and 2005 Chinese national surveys to study
      the students' physical fitness and health. Probit analyses were used to calculate
      age at menarche (AAM), and the heights and weights of 17-years-old girls in
      various minority groups. RESULTS: From 1985 to 2005, the increments of adult
      heights and weights increased significantly in many minority groups. The average 
      height of girls aged 17 years old in each minority group had an increase of 150
      cm in 2005. Ethnic groups with height growth rates of more than 1 cm per decade
      in girls aged 17 years old were Korean (1.47 cm/decade), Tujia (1.38 cm/decade), 
      Qiang (1.32 cm/decade), Bai (1.25 cm/decade), Hui (1.13 cm/decade) and Buyi (1.07
      cm/decade). And the minority ethics with weight growth rates of more than 1 kg
      per decade in girls aged 17 years old were Mongolian (1.79 kg/decade), Korean
      (1.69 kg/decade), Tibetan (1.66 kg/decade), Nakhi (1.39 kg/decade), Qiang (1.28
      kg/decade) and Hui (1.10 kg/decade). The overall AAM showed a downward rate in
      all the 19 minority groups, but with different degrees. Tujia, Yao and Nakhi
      showed the largest reductions, with AAMs as 2.15, 1.76 and 1.38 years earlier in 
      2005 than in 1985, respectively. CONCLUSION: Our data suggested that the downward
      secular trend in AAMs and the increments of adult heights might reflect the
      secular growth change in the major minority groups during the past 20 years, but 
      there was an obvious disequilibrium of puberty development and increments of
      heights in adults between the minority groups.
FAU - Song, Yi
AU  - Song Y
AD  - Institute of Child and Adolescent Health, Peking University Health Science
      Center, Beijing, China.
FAU - Hu, Pei-jin
AU  - Hu PJ
FAU - Zhang, Bing
AU  - Zhang B
FAU - Ma, Jun
AU  - Ma J
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Liu Xing Bing Xue Za Zhi
JT  - Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
JID - 8208604
SB  - IM
MH  - Adolescent
MH  - *Adolescent Development
MH  - China/ethnology
MH  - Female
MH  - Humans
MH  - Minority Groups/statistics & numerical data
EDAT- 2012/05/12 06:00
MHDA- 2014/05/16 06:00
CRDT- 2012/05/12 06:00
PHST- 2012/05/12 06:00 [entrez]
PHST- 2012/05/12 06:00 [pubmed]
PHST- 2014/05/16 06:00 [medline]
PST - ppublish
SO  - Zhonghua Liu Xing Bing Xue Za Zhi. 2012 Feb;33(2):192-6.


PMID- 22575122
OWN - NLM
STAT- MEDLINE
DCOM- 20140515
LR  - 20120511
IS  - 0254-6450 (Print)
IS  - 0254-6450 (Linking)
VI  - 33
IP  - 1
DP  - 2012 Jan
TI  - [Differences on ethical consciousness issues between the Chinese Journal of
      Epidemiology and the American Journal of Epidemiology].
PG  - 106-10
AB  - To compare the differences on current ethical issues in the areas of
      epidemiological practice between China and America, to identify the major ethical
      problems existing in the epidemiological studies in China. Through searching and 
      reviewing papers published on Chinese Journal of Epidemiology and American
      Journal of Epidemiology from Jan. 2006 to Dec. 2010, we made a comparison on
      ethical issues involved in the original studies that focusing on human beings. In
      total, 749 Chinese articles and 1221 American articles were recruited, with the
      following findings: (1) The proportion with announcements of "Informed consent by
      the subjects" was 29.24% in Chinese literature and 38.08% in the Americans
      (chi(2) = 16.02, P < 0.001). The proportion with "having had approvals from the
      ethic committees" was 29.24% in Chinese, while 38.08% in American (chi(2) =
      604.40, P < 0.0001). (2) Both in China and America, there had been an increase of
      ethical issues in the last 5 years. (3) Articles derived from trial studies had
      better involvement on ethics than those from observational studies. (4) The level
      on ethical issues in the American Research Institutes exceeded those in China (5)
      American studies also had showed better ideas on Ethic issues on biological
      specimens collection and privacy protection, than those in Chinese studies. Among
      the studies on Chinese Journal of Epidemiology, the proportion of 'informed
      consent' was higher than in ethical review, but both ethical review and awareness
      on 'informed consent' had left far behind than the American Journal of
      Epidemiology. This could be seen at the institution level of the writers, during 
      specimen collection and privacy protection, as well as at the overall level. The 
      results reminded us that the Departments of Technology Management should spend
      more efforts on the improvement of public education regarding ethics for
      researchers and to update the process of edition for Journals as well as to
      reinforce the rules of ethics in epidemiological research.
FAU - Meng, Ruo-gu
AU  - Meng RG
AD  - School of Public Health, Nanjing Medical University, China.
FAU - Zhai, Yan-bing
AU  - Zhai YB
FAU - Chen, Sen
AU  - Chen S
FAU - Zhang, Yan-chang
AU  - Zhang YC
FAU - Zhang, Yue-lun
AU  - Zhang YL
FAU - Zhao, Jian-yun
AU  - Zhao JY
FAU - Sun, Feng
AU  - Sun F
LA  - chi
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Liu Xing Bing Xue Za Zhi
JT  - Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
JID - 8208604
SB  - IM
MH  - China
MH  - *Epidemiology
MH  - *Ethics, Medical
MH  - *Periodicals as Topic
MH  - United States
EDAT- 2012/05/12 06:00
MHDA- 2014/05/16 06:00
CRDT- 2012/05/12 06:00
PHST- 2012/05/12 06:00 [entrez]
PHST- 2012/05/12 06:00 [pubmed]
PHST- 2014/05/16 06:00 [medline]
PST - ppublish
SO  - Zhonghua Liu Xing Bing Xue Za Zhi. 2012 Jan;33(1):106-10.


PMID- 22574646
OWN - NLM
STAT- MEDLINE
DCOM- 20121207
LR  - 20151119
IS  - 1365-2354 (Electronic)
IS  - 0961-5423 (Linking)
VI  - 21
IP  - 5
DP  - 2012 Sep
TI  - Nutritional support and quality of life in cancer patients undergoing palliative 
      care.
PG  - 581-90
LID - 10.1111/j.1365-2354.2012.01363.x [doi]
AB  - In palliative care, the nutrition provided has to be tailored to the patient's
      needs, enhancing patient comfort and quality of life (QoL). We conducted a
      literature search to review methods of measuring QoL, and modalities of
      nutritional intervention and their influence on QoL of cancer patients in
      palliative care. Original papers published in English were selected from PubMed
      database by using the search terms, palliative medicine, cancer, nutrition and
      quality of life. Specific tools that are particularly recommended to assess QoL
      in a palliative care setting are reviewed. The main goal in palliative care is to
      maintain oral nutrition by providing nutritional counselling. Enteral nutritional
      support showed inconsistent effects on survival and QoL. An evidence-base for
      parenteral nutrition is still lacking. Ethical considerations concerning
      provision of food and hydration in end-of-life care are discussed. Nutritional
      status should be assessed early and regularly during treatment using appropriate 
      tools. In the particularly acute context of palliative care, optimal patient
      management requires adequate education and counselling to patients and families. 
      Meaningful interactions between the patient, caregivers and medical team would
      also increase the chance of resolving nutrition-related issues and help to fulfil
      each patient's specific nutritional needs and thus improve the QoL.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Prevost, V
AU  - Prevost V
AD  - Universite de Caen Basse-Normandie EA 3936, INSERM U1086 - Cancers & Preventions,
      and Centre Regional de Lutte Contre le Cancer Francois Baclesse, Caen, France.
      virginie.prevost@unicaen.fr
FAU - Grach, M-C
AU  - Grach MC
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120511
PL  - England
TA  - Eur J Cancer Care (Engl)
JT  - European journal of cancer care
JID - 9301979
MH  - Communication
MH  - Humans
MH  - Malnutrition/diagnosis/*prevention & control
MH  - Neoplasms/psychology/*therapy
MH  - Nutrition Assessment
MH  - Nutritional Support/*methods
MH  - Palliative Care/*methods/psychology
MH  - *Quality of Life
MH  - Surveys and Questionnaires
EDAT- 2012/05/12 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/05/12 06:00
PHST- 2012/05/12 06:00 [entrez]
PHST- 2012/05/12 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - 10.1111/j.1365-2354.2012.01363.x [doi]
PST - ppublish
SO  - Eur J Cancer Care (Engl). 2012 Sep;21(5):581-90. doi:
      10.1111/j.1365-2354.2012.01363.x. Epub 2012 May 11.


PMID- 22574393
OWN - NLM
STAT- MEDLINE
DCOM- 20120614
LR  - 20191112
IS  - 0745-5194 (Print)
IS  - 0745-5194 (Linking)
VI  - 26
IP  - 1
DP  - 2012 Mar
TI  - Asthma episodes: stigma, children, and Hollywood films.
PG  - 92-115
AB  - Asthma has been systematically stigmatized in Hollywood feature films, including 
      films seen by children. Through content analysis of 66 movies containing one or
      more scenes showing asthma, and through informant interviews with a dozen U.S.
      children about representative scenes, the study explores how stigmatizing
      portrayals are interpreted, accepted, or resisted. Children suffering from asthma
      actively counterargued with incriminating excerpts, but in some respects their
      healthy friends were less critical. Overall, children viewed stigmatizing scenes 
      in terms of the social interaction and the social ethics entailed. They did not
      scrutinize the characters for damaged selfhood, per se, but dwelled on the social
      processes out of which stigma is erected.
FAU - Clark, Cindy Dell
AU  - Clark CD
AD  - Department of Anthropology, Rutgers University, Camden, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Anthropol Q
JT  - Medical anthropology quarterly
JID - 8405037
SB  - IM
MH  - Adolescent
MH  - Anthropology, Medical
MH  - Asthma/*psychology
MH  - Child
MH  - Humans
MH  - *Motion Pictures
MH  - *Social Stigma
MH  - *Stereotyping
MH  - United States
EDAT- 2012/05/12 06:00
MHDA- 2012/06/15 06:00
CRDT- 2012/05/12 06:00
PHST- 2012/05/12 06:00 [entrez]
PHST- 2012/05/12 06:00 [pubmed]
PHST- 2012/06/15 06:00 [medline]
AID - 10.1111/j.1548-1387.2011.01198.x [doi]
PST - ppublish
SO  - Med Anthropol Q. 2012 Mar;26(1):92-115. doi: 10.1111/j.1548-1387.2011.01198.x.


PMID- 22574388
OWN - NLM
STAT- MEDLINE
DCOM- 20120614
LR  - 20191112
IS  - 0745-5194 (Print)
IS  - 0745-5194 (Linking)
VI  - 26
IP  - 1
DP  - 2012 Mar
TI  - Introduction to the special focus section.
PG  - 1-3
AB  - The three articles presented in this special section of Medical Anthropology
      Quarterly are devoted to the ways that military servicemembers' bodies are
      figured, deployed, symbolized, and represented. These articles illustrate two
      issues that confront the members of many contemporary militaries exemplified here
      by examples from the United States and Turkey (Ben Ari 2001; Bickford 2011;
      Pengelly and Irwin 2010; Weiss 1998). The first is that they are embedded in a
      set of ethical relations with the state that deploys them to conflicts. Military 
      service confers a level of prestige and status, but it also entangles those who
      serve in complex social dilemmas. They are refigured as celebrated heroes in
      their communities but may also, as illustrated in Aciksoz's and Wool and
      Messinger's articles (this issue), find themselves dependent on their families
      and loved ones, as well as on military and state institutions. Servicemembers are
      also placed in new and complex relationships with their own bodies, and they come
      to experience vulnerability, mortality, and morality in novel and distinct ways.
FAU - Messinger, Seth D
AU  - Messinger SD
AD  - Department of Sociology and Anthropology, University of Maryland, Baltimore
      County, USA.
LA  - eng
PT  - Introductory Journal Article
PL  - United States
TA  - Med Anthropol Q
JT  - Medical anthropology quarterly
JID - 8405037
SB  - IM
MH  - *Anthropology, Medical
MH  - Humans
MH  - Military Personnel/*psychology
MH  - Turkey
MH  - United States
MH  - Veterans/*psychology
MH  - Veterans Health
MH  - Wounds and Injuries/psychology/rehabilitation
EDAT- 2012/05/12 06:00
MHDA- 2012/06/15 06:00
CRDT- 2012/05/12 06:00
PHST- 2012/05/12 06:00 [entrez]
PHST- 2012/05/12 06:00 [pubmed]
PHST- 2012/06/15 06:00 [medline]
AID - 10.1111/j.1548-1387.2011.01193.x [doi]
PST - ppublish
SO  - Med Anthropol Q. 2012 Mar;26(1):1-3. doi: 10.1111/j.1548-1387.2011.01193.x.


PMID- 22574081
OWN - NLM
STAT- MEDLINE
DCOM- 20120829
LR  - 20220408
IS  - 1844-3117 (Electronic)
IS  - 1844-122X (Linking)
VI  - 5
IP  - 1
DP  - 2012 Feb 22
TI  - The vegetative state--a syndrome in search of a name.
PG  - 3-15
AB  - In 2002, Bryan Jennett chose the caption "A syndrome in search of a name" for the
      first chapter of his book "The vegetative state--medical facts, ethical and legal
      dilemmas", which, in summary, can be taken as his legacy. Jennett coined the term
      "VegetativeState" (VS), which became the preferential name for the syndrome of
      wakeful unresponsiveness in the English literature, with the intention to specify
      the concern and dilemmas in connection with the naming "vegetative", "persistent"
      and "permanent". In Europe, Apallic Syndrome (AS) is still in use. The prevalence
      of VS/AS in hospital settings in Europe is 0.5-2/100.000 population year;
      one-third traumatic brain damage, 70% following intracranial haemorrhages,
      tumours, cerebral hypoxemia after cardiac arrest, and end stage of certain
      progressive neurological diseases. VS/AS reflects brain pathology of (a)
      consciousness, self-awareness, (b) behaviour, and (c) certain brain structures,
      so that patients are awake but total unresponsive. The ambiguity of the naming
      "vegetative" (meant to refer to the preserved vegetative (autonomous nervous
      system) can suggest that the patient is no more a human but "vegetable" like. And
      "apallic" does not mean being definitively and completely anatomically
      disconnected from neocortical structures. In 2009, having joined the
      International Task Force on the Vegetative State, we proposed the new term
      "Unresponsive Wakefulness Syndrome" (UWS) to enable (neuro-)scientists, the
      medical community, and the public to assess and define all stages accurately in a
      human way. The Unresponsive Wakefulness Syndrome (UWS) could replace the VS/AS
      nomenclature in science and public with social competence.
FAU - von Wild, K
AU  - von Wild K
AD  - Medical Faculty University Muenster, Cerebprotect Foerderverein fur
      Fruhrehabilitation eV, 48155 Muenster, Germany. kvw@neurosci.de
FAU - Laureys, S T
AU  - Laureys ST
FAU - Gerstenbrand, F
AU  - Gerstenbrand F
FAU - Dolce, G
AU  - Dolce G
FAU - Onose, G
AU  - Onose G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120305
PL  - Romania
TA  - J Med Life
JT  - Journal of medicine and life
JID - 101477617
SB  - IM
MH  - Diagnosis, Differential
MH  - Europe/epidemiology
MH  - Humans
MH  - Persistent Vegetative State/*diagnosis/*epidemiology/*physiopathology
MH  - Syndrome
MH  - *Terminology as Topic
PMC - PMC3307077
OTO - NOTNLM
OT  - Apallic syndrome
OT  - neurobehavioral disturbances
OT  - severe brain damage
OT  - unresponsive wakefulness syndrome
EDAT- 2012/05/11 06:00
MHDA- 2012/08/30 06:00
CRDT- 2012/05/11 06:00
PHST- 2011/09/09 00:00 [received]
PHST- 2012/01/20 00:00 [accepted]
PHST- 2012/05/11 06:00 [entrez]
PHST- 2012/05/11 06:00 [pubmed]
PHST- 2012/08/30 06:00 [medline]
PST - ppublish
SO  - J Med Life. 2012 Feb 22;5(1):3-15. Epub 2012 Mar 5.


PMID- 22573881
OWN - NLM
STAT- MEDLINE
DCOM- 20130122
LR  - 20161125
IS  - 1473-4257 (Electronic)
IS  - 0306-6800 (Linking)
VI  - 38
IP  - 9
DP  - 2012 Sep
TI  - Ethical questions must be considered for electronic health records.
PG  - 535-9
LID - 10.1136/medethics-2011-100413 [doi]
AB  - National electronic health record initiatives are in progress in many countries
      around the world but the debate about the ethical issues and how they are to be
      addressed remains overshadowed by other issues. The discourse to which all others
      are answerable is a technical discourse, even where matters of privacy and
      consent are concerned. Yet a focus on technical issues and a failure to think
      about ethics are cited as factors in the failure of the UK health record system. 
      In this paper, while the prime concern is the Australian Personally Controlled
      Electronic Health Record (PCEHR), the discussion is relevant to and informed by
      the international context. The authors draw attention to ethical and conceptual
      issues that have implications for the success or failure of electronic health
      records systems. Important ethical issues to consider as Australia moves towards 
      a PCEHR system include: issues of equity that arise in the context of personal
      control, who benefits and who should pay, what are the legitimate uses of PCEHRs,
      and how we should implement privacy. The authors identify specific questions that
      need addressing.
FAU - Spriggs, Merle
AU  - Spriggs M
AD  - Health Ethics & Policy, Murdoch Childrens Research Institute, Flemington Road,
      Parkville, Victoria 3052, Australia. merle.spriggs@mcri.edu.au
FAU - Arnold, Michael V
AU  - Arnold MV
FAU - Pearce, Christopher M
AU  - Pearce CM
FAU - Fry, Craig
AU  - Fry C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120509
PL  - England
TA  - J Med Ethics
JT  - Journal of medical ethics
JID - 7513619
SB  - IM
MH  - Access to Information
MH  - Attitude to Computers
MH  - Australia
MH  - Computer Security/ethics
MH  - Confidentiality/ethics
MH  - Electronic Health Records/*ethics/legislation & jurisprudence
MH  - Health Knowledge, Attitudes, Practice
MH  - Health Policy/legislation & jurisprudence
MH  - Humans
MH  - National Health Programs/*ethics/legislation & jurisprudence
MH  - Practice Guidelines as Topic
MH  - United Kingdom
EDAT- 2012/05/11 06:00
MHDA- 2013/01/23 06:00
CRDT- 2012/05/11 06:00
PHST- 2012/05/11 06:00 [entrez]
PHST- 2012/05/11 06:00 [pubmed]
PHST- 2013/01/23 06:00 [medline]
AID - medethics-2011-100413 [pii]
AID - 10.1136/medethics-2011-100413 [doi]
PST - ppublish
SO  - J Med Ethics. 2012 Sep;38(9):535-9. doi: 10.1136/medethics-2011-100413. Epub 2012
      May 9.


PMID- 22573840
OWN - NLM
STAT- MEDLINE
DCOM- 20120927
LR  - 20120510
IS  - 1525-3163 (Electronic)
IS  - 0021-8812 (Linking)
VI  - 90
IP  - 5
DP  - 2012 May
TI  - Bioethics Symposium: The ethical food movement: What does it mean for the role of
      science and scientists in current debates about animal agriculture?
PG  - 1570-82
LID - 10.2527/jas.2011-4702 [doi]
AB  - Contemporary animal agriculture is increasingly criticized on ethical grounds.
      Consequently, current policy and legislative discussions have become highly
      controversial as decision makers attempt to reconcile concerns about the impacts 
      of animal production on animal welfare, the environment, and on the efficacy of
      antibiotics required to ensure human health with demands for abundant,
      affordable, safe food. Clearly, the broad implications for US animal agriculture 
      of what appears to be a burgeoning movement relative to ethical food production
      must be understood by animal agriculture stakeholders. The potential effects of
      such developments on animal agricultural practices, corporate marketing
      strategies, and public perceptions of the ethics of animal production must also
      be clarified. To that end, it is essential to acknowledge that people's beliefs
      about which food production practices are appropriate are tied to diverse, latent
      value systems. Thus, relying solely on scientific information as a means to
      resolve current debates about animal agriculture is unlikely to be effective. The
      problem is compounded when scientific information is used inappropriately or
      strategically to advance a political agenda. Examples of the interface between
      science and ethics in regards to addressing currently contentious aspects of food
      animal production (animal welfare, antimicrobial use, and impacts of animal
      production practices on the environment) are reviewed. The roles of scientists
      and science in public debates about animal agricultural practices are also
      examined. It is suggested that scientists have a duty to contribute to the
      development of sound policy by providing clear and objectively presented
      information, by clarifying misinterpretations of science, and by recognizing the 
      differences between presenting data vs. promoting their own value judgments in
      regard to how and which data should be used to establish policy. Finally, the
      role of the media in shaping public opinions on key issues pertaining to animal
      agriculture is also discussed.
FAU - Croney, C C
AU  - Croney CC
AD  - Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA. 
      ccroney@purdue.edu
FAU - Apley, M
AU  - Apley M
FAU - Capper, J L
AU  - Capper JL
FAU - Mench, J A
AU  - Mench JA
FAU - Priest, S
AU  - Priest S
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Anim Sci
JT  - Journal of animal science
JID - 8003002
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Agriculture/*ethics/*legislation & jurisprudence
MH  - Animal Welfare/*ethics
MH  - Animals
MH  - Anti-Bacterial Agents/administration & dosage
MH  - Bioethics/*trends
MH  - Drug Utilization
MH  - Livestock/*physiology
MH  - Policy
EDAT- 2012/05/11 06:00
MHDA- 2012/09/28 06:00
CRDT- 2012/05/11 06:00
PHST- 2012/05/11 06:00 [entrez]
PHST- 2012/05/11 06:00 [pubmed]
PHST- 2012/09/28 06:00 [medline]
AID - 90/5/1570 [pii]
AID - 10.2527/jas.2011-4702 [doi]
PST - ppublish
SO  - J Anim Sci. 2012 May;90(5):1570-82. doi: 10.2527/jas.2011-4702.


PMID- 22573527
OWN - NLM
STAT- MEDLINE
DCOM- 20130619
LR  - 20121003
IS  - 1724-6059 (Electronic)
IS  - 1121-8428 (Linking)
VI  - 25 Suppl 19
DP  - 2012
TI  - Ethical considerations in nephro-geriatrics.
PG  - S6-10
LID - 10.5301/jn.5000165 [doi]
AB  - Life expectancy and quality of life may be rather poor in elderly patients with
      chronic kidney disease stage V. This raises a number of issues surrounding the
      decision of whether or not to commence renal replacement therapy and about the
      right timing of this. Those starting dialysis appear to have a better outcome;
      however, important selection bias is very likely and the survival advantage
      offered by dialysis is markedly reduced in patients with severe comorbidities.
      Moreover, those commencing dialysis are more likely to be hospitalized than those
      managed conservatively. Cognitive impairment, dependence on daily activities,
      comorbidities, and life expectancy are relevant factors that need to be
      considered in order to decide whether or not to start dialysis. However,
      guidelines and severity scores are still of little help. Cultural, religious,
      legal, and educational aspects further complicate the scene.
FAU - Del Vecchio, Lucia
AU  - Del Vecchio L
AD  - Department of Nephrology, Dialysis and Renal Transplant, A Manzoni Hospital,
      Lecco, Italy.
FAU - Locatelli, Francesco
AU  - Locatelli F
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - J Nephrol
JT  - Journal of nephrology
JID - 9012268
SB  - IM
MH  - Aged
MH  - *Geriatrics
MH  - Glomerular Filtration Rate
MH  - Humans
MH  - *Nephrology
MH  - Renal Insufficiency, Chronic/*therapy
MH  - Renal Replacement Therapy/*ethics
EDAT- 2012/05/11 06:00
MHDA- 2013/06/20 06:00
CRDT- 2012/05/11 06:00
PHST- 2012/03/19 00:00 [accepted]
PHST- 2012/05/11 06:00 [entrez]
PHST- 2012/05/11 06:00 [pubmed]
PHST- 2013/06/20 06:00 [medline]
AID - 4F7197AC-9E95-4A93-9C0F-DA9D28ADCBB1 [pii]
AID - 10.5301/jn.5000165 [doi]
PST - ppublish
SO  - J Nephrol. 2012;25 Suppl 19:S6-10. doi: 10.5301/jn.5000165.


PMID- 22572573
OWN - NLM
STAT- MEDLINE
DCOM- 20121231
LR  - 20161021
IS  - 1578-1291 (Electronic)
IS  - 1130-2399 (Linking)
VI  - 23
IP  - 3
DP  - 2012 Jul-Sep
TI  - [Limits of therapeutic effort. Professional opinions].
PG  - 104-14
LID - 10.1016/j.enfi.2011.12.008 [doi]
AB  - INTRODUCTION: In our clinical practice we find the need to care for patients with
      irreversible conditions, due to advanced age or underlying chronic disease, and a
      change in the types of disease currently facing the health workforce.The
      objective of this research was to study the ethical assessment of health
      professionals in our Hospital on extraordinary life support measures. MATERIAL
      AND METHODS: Prospective descriptive study conducted at the Hospital General
      Universitario de Ciudad Real during the months of April to August 2010. The
      convenience sample consisted of 189 professionals from different categories
      working in our hospital during the study period.It included a questionnaire
      adapted for use in hospitals, comprising 18 items with dichotomous
      responses.Informed consent was requested and the confidentiality of information
      ensured. RESULTS: A sample of 189 professionals, of whom 21.7% were male and
      78.3% were female. The mean age was 40.39 years SD + 10, with a mode of 31
      years.The professionals involved were doctors, nurses and nursing assistants,
      with an average experience of 15.8% +/- 10.4 SD years.A total of 79.9% were in
      favour of euthanasia, 93.6% against dysthanasia, 92.6% for antidysthanasia, and
      99.5% for orthotonasia. The medical group was the one most against the use of
      euthanasia P=.0001. Differences were found between religious practice and the
      ethical situations at the end of life. CONCLUSIONS: Most participants took into
      account the patient's decision to limit extraordinary measures in terminal
      disease situations.The study reveals that the effectiveness and usefulness of our
      clinical practice should include an ethical evaluation by professionals with the 
      patient. It became clear that the majority of the sample of professionals is
      against over-aggressive treatment, and for a dignified death.
CI  - Copyright (c) 2011 Elsevier Espana, S.L. y SEEIUC. All rights reserved.
FAU - Munoz Camargo, J C
AU  - Munoz Camargo JC
AD  - Unidad de Cuidados Intensivos, Hospital General Universitario, Ciudad Real,
      Espana. papias@terra.es
FAU - Martin Tercero, M P
AU  - Martin Tercero MP
FAU - Nunez Lopez, M P
AU  - Nunez Lopez MP
FAU - Espadas Maeso, M J
AU  - Espadas Maeso MJ
FAU - Perez Fernandez-Infantes, S
AU  - Perez Fernandez-Infantes S
FAU - Cinjordis Valverde, P
AU  - Cinjordis Valverde P
FAU - Leon Rodriguez, A
AU  - Leon Rodriguez A
FAU - Moreno Ortiz, J
AU  - Moreno Ortiz J
FAU - Huertas Diaz, M P
AU  - Huertas Diaz MP
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Limitacion del esfuerzo terapeutico. Opinion de los profesionales.
DEP - 20120507
PL  - Spain
TA  - Enferm Intensiva
JT  - Enfermeria intensiva
JID - 9517771
MH  - Adult
MH  - Aged
MH  - *Attitude of Health Personnel
MH  - Female
MH  - Humans
MH  - Life Support Care/*ethics
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2012/05/11 06:00
MHDA- 2013/01/01 06:00
CRDT- 2012/05/11 06:00
PHST- 2011/07/27 00:00 [received]
PHST- 2011/11/27 00:00 [revised]
PHST- 2011/12/07 00:00 [accepted]
PHST- 2012/05/11 06:00 [entrez]
PHST- 2012/05/11 06:00 [pubmed]
PHST- 2013/01/01 06:00 [medline]
AID - S1130-2399(11)00096-4 [pii]
AID - 10.1016/j.enfi.2011.12.008 [doi]
PST - ppublish
SO  - Enferm Intensiva. 2012 Jul-Sep;23(3):104-14. doi: 10.1016/j.enfi.2011.12.008.
      Epub 2012 May 7.


PMID- 22571768
OWN - NLM
STAT- MEDLINE
DCOM- 20140326
LR  - 20191210
IS  - 1945-1474 (Electronic)
IS  - 1062-2551 (Linking)
VI  - 35
IP  - 4
DP  - 2013 Jul-Aug
TI  - Using the Malcolm Baldrige "are we making progress" survey for organizational
      self-assessment and performance improvement.
PG  - 5-15
LID - 10.1111/j.1945-1474.2011.00191.x [doi]
AB  - A national healthcare company applied the Malcolm Baldrige Criteria for
      Performance Excellence and its "Are We Making Progress?" survey as an annual
      organizational self-assessment to identify areas for improvement. For 6 years,
      Liberty Healthcare Corporation reviewed the survey results on an annual basis to 
      analyze positive and negative trends, monitor company progress toward targeted
      goals and develop new initiatives to address emerging areas for improvement. As
      such, the survey provided a simple and inexpensive methodology to gain useful
      information from employees at all levels and from multiple service sites and
      business sectors. In particular, it provided a valuable framework for assessing
      and improving the employees' commitment to the company's mission and values, high
      standards and ethics, quality of work, and customer satisfaction. The methodology
      also helped the company to incorporate the philosophy and principles of
      continuous quality improvement in a unified fashion. Corporate and local
      leadership used the same measure to evaluate the performance of individual
      programs relative to each other, to the company as a whole, and to the "best
      practices" standard of highly successful companies that received the Malcolm
      Baldrige National Quality Award.
CI  - (c) 2012 National Association for Healthcare Quality.
FAU - Shields, Judith A
AU  - Shields JA
AD  - judiths@libertyhealth.com
FAU - Jennings, Jerry L
AU  - Jennings JL
LA  - eng
PT  - Journal Article
DEP - 20120509
PL  - United States
TA  - J Healthc Qual
JT  - Journal for healthcare quality : official publication of the National Association
      for Healthcare Quality
JID - 9202994
EIN - J Healthc Qual. 2013 Jul-Aug;35(4):5
MH  - Attitude of Health Personnel
MH  - Benchmarking
MH  - Female
MH  - Health Services Administration/*standards
MH  - Humans
MH  - Leadership
MH  - Male
MH  - Management Quality Circles/*organization & administration/standards
MH  - Organizational Case Studies
MH  - Organizational Innovation
MH  - Outcome and Process Assessment, Health Care/methods/*organization &
      administration
MH  - Surveys and Questionnaires
MH  - Total Quality Management/methods/*organization & administration
MH  - United States
OTO - NOTNLM
OT  - leadership
OT  - organizational change
OT  - quality improvement
OT  - quality measures
EDAT- 2012/05/11 06:00
MHDA- 2014/03/29 06:00
CRDT- 2012/05/11 06:00
PHST- 2012/05/11 06:00 [entrez]
PHST- 2012/05/11 06:00 [pubmed]
PHST- 2014/03/29 06:00 [medline]
AID - 10.1111/j.1945-1474.2011.00191.x [doi]
PST - ppublish
SO  - J Healthc Qual. 2013 Jul-Aug;35(4):5-15. doi: 10.1111/j.1945-1474.2011.00191.x.
      Epub 2012 May 9.


PMID- 22571650
OWN - NLM
STAT- MEDLINE
DCOM- 20130429
LR  - 20121126
IS  - 1473-0766 (Electronic)
IS  - 0951-3590 (Linking)
VI  - 28
IP  - 12
DP  - 2012 Dec
TI  - Fertility preservation for women with malignant diseases: ethical aspects and
      risks.
PG  - 937-40
LID - 10.3109/09513590.2012.683077 [doi]
AB  - As cancer treatment becomes more and more effective, there is greater life
      expectancy for cancer patients. Because of this, depending upon the modality used
      in the treatment of cancer, the matter of infertility emerges before us as an
      issue of increasing significance. Sperm cryopreservation and embryo
      cryopreservation are well-established methods of fertility preservation (FP).
      Besides these validated FP options, some FP techniques such as oocyte
      cryopreservation and ovarian tissue cryopreservation are as yet in the
      experimental stage. FP medicine has experienced some rapid developments in recent
      years. The advances in this branch of medicine, however, have also brought about 
      new ethical, medical and legal issues. Some of these include problems with
      obtaining the informed consent of minors, issues that arise because of the
      experimental nature of some methods, financial problems and the accessibility of 
      FP methods, and the question of what happens to gametes when a patient dies. This
      review seeks to discuss, in the light of current literature, some ethical and
      technical issues and risks related to the implementation of FP methods in women
      with cancer.
FAU - Kucuk, Mert
AU  - Kucuk M
AD  - Department of Obstetrics and Gynecology, Faculty of Medicine, Adnan Menderes
      University, Aydin, Turkey. dr.mertkucuk@gmail.com
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120510
PL  - England
TA  - Gynecol Endocrinol
JT  - Gynecological endocrinology : the official journal of the International Society
      of Gynecological Endocrinology
JID - 8807913
SB  - IM
MH  - Female
MH  - Fertility Preservation/ethics/legislation & jurisprudence/*methods/psychology
MH  - Humans
MH  - Infertility, Female/*complications/etiology/psychology/therapy
MH  - Informed Consent/ethics/legislation & jurisprudence/psychology
MH  - Informed Consent By Minors/ethics/legislation & jurisprudence/psychology
MH  - Male
MH  - Neoplasms/*complications/diagnosis/psychology/therapy
MH  - Prognosis
MH  - Therapies, Investigational/adverse effects/ethics
EDAT- 2012/05/11 06:00
MHDA- 2013/04/30 06:00
CRDT- 2012/05/11 06:00
PHST- 2012/05/11 06:00 [entrez]
PHST- 2012/05/11 06:00 [pubmed]
PHST- 2013/04/30 06:00 [medline]
AID - 10.3109/09513590.2012.683077 [doi]
PST - ppublish
SO  - Gynecol Endocrinol. 2012 Dec;28(12):937-40. doi: 10.3109/09513590.2012.683077.
      Epub 2012 May 10.


PMID- 22571623
OWN - NLM
STAT- MEDLINE
DCOM- 20130507
LR  - 20121109
IS  - 1937-3376 (Electronic)
IS  - 1937-3368 (Linking)
VI  - 18
IP  - 6
DP  - 2012 Dec
TI  - Reducing the number of laboratory animals used in tissue engineering research by 
      restricting the variety of animal models. Articular cartilage tissue engineering 
      as a case study.
PG  - 427-35
LID - 10.1089/ten.TEB.2012.0059 [doi]
AB  - The use of laboratory animals in tissue engineering research is an important
      underexposed ethical issue. Several ethical questions may be raised about this
      use of animals. This article focuses on the possibilities of reducing the number 
      of animals used. Given that there is considerable debate about the adequacy of
      the current animal models in tissue engineering research, we investigate whether 
      it is possible to reduce the number of laboratory animals by selecting and using 
      only those models that have greatest predictive value for future clinical
      application of the tissue engineered product. The field of articular cartilage
      tissue engineering is used as a case study. Based on a study of the scientific
      literature and interviews with leading experts in the field, an overview is
      provided of the animal models used and the advantages and disadvantages of each
      model, particularly in terms of extrapolation to the human situation. Starting
      from this overview, it is shown that, by skipping the small models and using only
      one large preclinical model, it is indeed possible to restrict the number of
      animal models, thereby reducing the number of laboratory animals used. Moreover, 
      it is argued that the selection of animal models should become more evidence
      based and that researchers should seize more opportunities to choose or create
      characteristics in the animal models that increase their predictive value.
FAU - de Vries, Rob B M
AU  - de Vries RB
AD  - SYRCLE/3R Research Centre, Central Animal Laboratory (Post 231), Radboud
      University Nijmegen Medical Centre, Nijmegen, The Netherlands.
      r.devries@cdl.umcn.nl
FAU - Buma, Pieter
AU  - Buma P
FAU - Leenaars, Marlies
AU  - Leenaars M
FAU - Ritskes-Hoitinga, Merel
AU  - Ritskes-Hoitinga M
FAU - Gordijn, Bert
AU  - Gordijn B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120625
PL  - United States
TA  - Tissue Eng Part B Rev
JT  - Tissue engineering. Part B, Reviews
JID - 101466660
SB  - IM
MH  - Animal Testing Alternatives/*ethics
MH  - Animals
MH  - *Animals, Laboratory
MH  - Biomedical Research/*standards
MH  - Cartilage, Articular/*growth & development/pathology
MH  - Humans
MH  - *Models, Animal
MH  - *Tissue Engineering
EDAT- 2012/05/11 06:00
MHDA- 2013/05/08 06:00
CRDT- 2012/05/11 06:00
PHST- 2012/05/11 06:00 [entrez]
PHST- 2012/05/11 06:00 [pubmed]
PHST- 2013/05/08 06:00 [medline]
AID - 10.1089/ten.TEB.2012.0059 [doi]
PST - ppublish
SO  - Tissue Eng Part B Rev. 2012 Dec;18(6):427-35. doi: 10.1089/ten.TEB.2012.0059.
      Epub 2012 Jun 25.


PMID- 22571554
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20211021
IS  - 1824-7288 (Electronic)
IS  - 1720-8424 (Linking)
VI  - 38
DP  - 2012 May 9
TI  - Severe reaction in a child with asymptomatic codfish allergy: food challenge
      reactivating recurrent pancreatitis.
PG  - 16
LID - 10.1186/1824-7288-38-16 [doi]
AB  - An 8-year-old child during the first year of life manifested severe atopic
      dermatitis and chronic diarrhea with mucorrhea and rectal bleeding; a fish-free
      diet was started based on weakly positive skin-prick tests to codfish extract. At
      the age of 4 years the child began to suffer of recurrent pancreatitis. When he
      came to our attention for the evaluation of his fish allergy, he was
      asymptomatic; a weak reactivity to codfish was observed (SPTs: cod, 4 mm, sIgE
      ImmunoCAP: cod, 1.30 kU/l). The food challenge test with cod was negative. When
      the child ate cod again, within 5 minutes, developed anaphylactic reaction and
      complained of abdominal pain compatible with pancreatitis (enzyme serum levels
      risen and parenchymal oedema at ultrasonography), that resolved within 7 days
      after specific therapy. This case raises two issues: the elimination diet in
      asymptomatic food allergy on the basis only of SPT and the ethicality of food
      challenge in gastrointestinal chronic disease.
FAU - Pellegrino, Katia
AU  - Pellegrino K
AD  - Department of Paediatric Medicine-Allergy Unit, I.R.C.C.S. Children's Hospital
      Bambino Gesu, Rome, Italy.
FAU - D'Urbano, Leila Emma
AU  - D'Urbano LE
FAU - Artesani, Maria Cristina
AU  - Artesani MC
FAU - Riccardi, Carla
AU  - Riccardi C
FAU - Mancini, Sandro
AU  - Mancini S
FAU - Bella, Sergio
AU  - Bella S
FAU - Alghisi, Federico
AU  - Alghisi F
FAU - Cavagni, Giovanni
AU  - Cavagni G
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20120509
PL  - England
TA  - Ital J Pediatr
JT  - Italian journal of pediatrics
JID - 101510759
SB  - IM
MH  - Animals
MH  - Child
MH  - Diagnosis, Differential
MH  - Food Hypersensitivity/diagnosis/*immunology/therapy
MH  - Gadus morhua/*immunology
MH  - Humans
MH  - Male
MH  - Pancreatitis/diagnosis/*immunology/therapy
MH  - Recurrence
PMC - PMC3462688
EDAT- 2012/05/11 06:00
MHDA- 2013/03/13 06:00
CRDT- 2012/05/11 06:00
PHST- 2011/01/24 00:00 [received]
PHST- 2012/02/22 00:00 [accepted]
PHST- 2012/05/11 06:00 [entrez]
PHST- 2012/05/11 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
AID - 1824-7288-38-16 [pii]
AID - 10.1186/1824-7288-38-16 [doi]
PST - epublish
SO  - Ital J Pediatr. 2012 May 9;38:16. doi: 10.1186/1824-7288-38-16.


PMID- 22571427
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20141120
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 26
IP  - 5
DP  - 2012 Jun
TI  - Ethics and chronic disease: where are the bioethicists?
PG  - ii-iv
LID - 10.1111/j.1467-8519.2012.01974.x [doi]
FAU - Gibson, Jennifer L
AU  - Gibson JL
FAU - Upshur, Ross E G
AU  - Upshur RE
LA  - eng
PT  - Editorial
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - *Chronic Disease
MH  - *Ethicists
MH  - *Ethics, Clinical
MH  - Global Health
MH  - Humans
MH  - *Periodicals as Topic
MH  - *Publishing
EDAT- 2012/05/11 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/05/11 06:00
PHST- 2012/05/11 06:00 [entrez]
PHST- 2012/05/11 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
AID - 10.1111/j.1467-8519.2012.01974.x [doi]
PST - ppublish
SO  - Bioethics. 2012 Jun;26(5):ii-iv. doi: 10.1111/j.1467-8519.2012.01974.x.


PMID- 22571425
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20120510
IS  - 1467-8519 (Electronic)
IS  - 0269-9702 (Linking)
VI  - 26
IP  - 5
DP  - 2012 Jun
TI  - The dangers of euthanasia and dementia: how Kantian thinking might be used to
      support non-voluntary euthanasia in cases of extreme dementia.
PG  - 231-5
LID - 10.1111/j.1467-8519.2011.01951.x [doi]
AB  - Some writers have argued that a Kantian approach to ethics can be used to justify
      suicide in cases of extreme dementia, where a patient lacks the rationality
      required of Kantian moral agents. I worry that this line of thinking may lead to 
      the more extreme claim that euthanasia is a proper Kantian response to severe
      dementia (and similar afflictions). Such morally treacherous thinking seems to be
      directly implied by the arguments that lead Dennis Cooley and similar writers to 
      claim that Kant might support suicide. If rationality is the only factor in
      valuing a human life, then the loss of that rationality (however such loss might 
      be defined) would allow us to use essentially utilitarian thinking in order to
      support non-voluntary euthanasia, since the patients themselves would no longer
      be moral agents that demand respect.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Sharp, Robert
AU  - Sharp R
AD  - Muskingum University, New Concord, Ohio 43762, USA. rsharp9@columbus.rr.com
LA  - eng
PT  - Journal Article
PL  - England
TA  - Bioethics
JT  - Bioethics
JID - 8704792
SB  - IM
MH  - *Dementia
MH  - Ethical Theory
MH  - Euthanasia/*ethics
MH  - Humans
MH  - Moral Obligations
MH  - Personhood
MH  - Suicide, Assisted/*ethics
MH  - *Wedge Argument
EDAT- 2012/05/11 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/05/11 06:00
PHST- 2012/05/11 06:00 [entrez]
PHST- 2012/05/11 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
AID - 10.1111/j.1467-8519.2011.01951.x [doi]
PST - ppublish
SO  - Bioethics. 2012 Jun;26(5):231-5. doi: 10.1111/j.1467-8519.2011.01951.x.


PMID- 22570569
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1179-1349 (Electronic)
IS  - 1179-1349 (Linking)
VI  - 4
DP  - 2012
TI  - Ethical principles for project collaboration between academic professionals or
      institutions and the biomedical industry.
PG  - 95-7
LID - 10.2147/CLEP.S23033 [doi]
AB  - Ethics in biomedical research cannot be defined by etymology, and need a semantic
      definition based on national and contemporary values. In a Nordic cultural and
      historic context, key values are solidarity with one's fellow man, equality,
      truth, justice, responsibility, freedom, and professionalism. In contemporary
      medical research, such ethics are further subgrouped into research ethics,
      researcher ethics, societal ethics, and distributive ethics. Lately, public and
      academic debates have addressed the necessary strengthening of the ethical
      concerns and interests of patients and society. Despite considerable progress,
      common ethical definitions and control systems still lack uniformity or indeed do
      not exist. Among the cooperative partners involved, the pharmaceutical industry
      have preserved an important role. The same is true for the overall judgments
      reflected by the European Forum for Good Clinical Practice, leading peer-reviewed
      journals, the Nuffield Council on Bioethics for developing nations, and the
      latest global initiative, the Singapore Statement on Research Integrity. To help 
      both institutions and countries, it will be valuable to include the following
      information in academia-industry protocols before starting a project:
      international authorship names; fixed agendas and time schedules for project
      meetings; chairperson shifts, meeting reports, and project plan changes; future
      author memberships; equal blinding and data distribution from disciplinary
      groups; an equal plan for exchange of project manuscripts at the proofing stage; 
      contractual descriptions of all procedures, disagreements, publishing rights,
      prevention, and controls for suspected dishonesty; and a detailed description of 
      who is doing what in the working process.
FAU - Riis, Povl
AU  - Riis P
AD  - Age Forum, State Board for Research and Age Policies, Odense, Denmark.
LA  - eng
PT  - Journal Article
DEP - 20120416
PL  - New Zealand
TA  - Clin Epidemiol
JT  - Clinical epidemiology
JID - 101531700
PMC - PMC3346205
OTO - NOTNLM
OT  - academia
OT  - biomedical industry
OT  - collaboration
OT  - ethics
EDAT- 2012/05/10 06:00
MHDA- 2012/05/10 06:01
CRDT- 2012/05/10 06:00
PHST- 2012/05/10 06:00 [entrez]
PHST- 2012/05/10 06:00 [pubmed]
PHST- 2012/05/10 06:01 [medline]
AID - 10.2147/CLEP.S23033 [doi]
AID - clep-4-095 [pii]
PST - ppublish
SO  - Clin Epidemiol. 2012;4:95-7. doi: 10.2147/CLEP.S23033. Epub 2012 Apr 16.


PMID- 22570506
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 264
IP  - 1
DP  - 2012 Jul
TI  - Virtual nonenhanced dual-energy CT urography with tin-filter technology:
      determinants of detection of urinary calculi in the renal collecting system.
PG  - 119-25
LID - 10.1148/radiol.12110851 [doi]
AB  - PURPOSE: To retrospectively determine which features of urinary calculi are
      associated with their detection after virtual elimination of contrast medium at
      dual-energy computed tomographic (CT) urography by using a novel tin filter.
      MATERIALS AND METHODS: The institutional ethics committee approved this
      retrospective study, with waiver of informed consent. A total of 152 patients
      were examined with single-energy nonenhanced CT and dual-energy CT urography in
      the excretory phase (either 140 and 80 kV [n=44] or 140 and 100 kV [n=108], with 
      tin filtration at 140 kV). The contrast medium in the renal pelvis and ureters
      was virtually removed from excretory phase images by using postprocessing
      software, resulting in virtual nonenhanced (VNE) images. The sensitivity
      regarding the detection of calculi on VNE images compared with true nonenhanced
      (TNE) images was determined, and interrater agreement was evaluated by using the 
      Cohen k test. By using logistic regression, the influences of image noise,
      attenuation, and stone size, as well as attenuation of the contrast medium, on
      the stone detection rate were assessed. Threshold values with maximal sensitivity
      and specificity were calculated by means of receiver operating characteristic
      analyses. RESULTS: Eighty-seven stones were detected on TNE images; 46 calculi
      were identified on VNE images (sensitivity, 52.9%). Interrater agreement revealed
      a kappa value of 0.95 with TNE images and 0.91 with VNE data. Size (long-axis
      diameter, P=.005; short-axis diameter, P=.041) and attenuation (P=.0005) of the
      calculi and image noise (P=.0031) were significantly associated with the
      detection rate on VNE images. As threshold values, size larger than 2.9 mm,
      maximum attenuation of the calculi greater than 387 HU, and image noise less than
      20 HU were found. CONCLUSION: After virtual elimination of contrast medium, large
      (>2.9 mm) and high-attenuation (>387 HU) calculi can be detected with good
      reliability; smaller and lower attenuation calculi might be erased from images,
      especially with increased image noise.
CI  - (c) RSNA, 2012.
FAU - Mangold, Stefanie
AU  - Mangold S
AD  - Department of Diagnostic and Interventional Radiology, Eberhard-Karls-University 
      Tuebingen, Hoppe-Seyler-Str. 3, 72076 Tuebingen, Germany.
FAU - Thomas, Christoph
AU  - Thomas C
FAU - Fenchel, Michael
AU  - Fenchel M
FAU - Vuust, Morten
AU  - Vuust M
FAU - Krauss, Bernhard
AU  - Krauss B
FAU - Ketelsen, Dominik
AU  - Ketelsen D
FAU - Tsiflikas, Ilias
AU  - Tsiflikas I
FAU - Claussen, Claus D
AU  - Claussen CD
FAU - Heuschmid, Martin
AU  - Heuschmid M
LA  - eng
PT  - Journal Article
DEP - 20120508
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Contrast Media)
RN  - 0 (Triiodobenzoic Acids)
RN  - N3RIB7X24K (ioversol)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Algorithms
MH  - Contrast Media
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - ROC Curve
MH  - Radiographic Image Interpretation, Computer-Assisted
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - Tomography, X-Ray Computed/*methods
MH  - Triiodobenzoic Acids
MH  - Urinary Calculi/*diagnostic imaging
MH  - Urography
EDAT- 2012/05/10 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/05/10 06:00
PHST- 2012/05/10 06:00 [entrez]
PHST- 2012/05/10 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
AID - radiol.12110851 [pii]
AID - 10.1148/radiol.12110851 [doi]
PST - ppublish
SO  - Radiology. 2012 Jul;264(1):119-25. doi: 10.1148/radiol.12110851. Epub 2012 May 8.


PMID- 22570505
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20120622
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 264
IP  - 1
DP  - 2012 Jul
TI  - Diagnostic performance of dual-energy CT for the detection of traumatic bone
      marrow lesions in the ankle: comparison with MR imaging.
PG  - 164-73
LID - 10.1148/radiol.12112217 [doi]
AB  - PURPOSE: To evaluate prospectively the performance of noncalcium images
      reconstructed from dual-energy (DE) computed tomography (CT) for the diagnosis of
      bone marrow lesions in patients with acute ankle joint trauma in comparison with 
      magnetic resonance (MR) images. MATERIALS AND METHODS: The study had local ethics
      board approval, and written informed consent was obtained. Thirty consecutive
      patients (15 women; mean age, 34 years+/-11.8 [standard deviation]) underwent
      dual-source DE CT (80 kVp and 140 kVp with tin filter) and MR imaging within 1
      day following acute ankle trauma. DE CT data were postprocessed by using a
      three-material decomposition algorithm for generating noncalcium images. MR and
      noncalcium images were graded by two blinded, independent readers using a
      four-point system (1=distinct bone marrow lesion, 4=no lesion); CT numbers in
      noncalcium images were calculated by a third reader. MR imaging interpretations
      served as the reference standard. RESULTS: Interreader agreement for qualitative 
      grading of DE CT images was substantial (kappa=0.66). The respective sensitivity,
      specificity, positive predictive value, and negative predictive value of DE CT
      for depicting distinct bone marrow lesions for both readers were 90.0% each,
      80.5% and 81.6%, 25.4% and 26.5%, and 99.1% each. In regions without abnormality,
      CT numbers in noncalcium images gradually increased from proximal to distal
      location (P<.001). Significant differences in CT numbers were found in regions
      positive for bone marrow lesions compared with those that were negative (P<.001).
      CT numbers for the diagnosis of distinct bone marrow lesions according to MR
      imaging revealed areas under the receiver operating characteristic curve of
      0.973, 0.813, and 0.758 for ankle mortise, talar dome, and talar body/head,
      respectively. CONCLUSION: Compared with MR images, distinct traumatic bone marrow
      lesions of the ankle joint can be diagnosed on noncalcium images reconstructed
      from DE CT with high sensitivity and excellent negative predictive value, but
      with moderate specificity and low positive predictive value.
CI  - (c) RSNA, 2012.
FAU - Guggenberger, Roman
AU  - Guggenberger R
AD  - Department of Radiology, University Hospital Zurich, Ramistrasse 100, 8091
      Zurich, Switzerland.
FAU - Gnannt, Ralph
AU  - Gnannt R
FAU - Hodler, Juerg
AU  - Hodler J
FAU - Krauss, Bernhard
AU  - Krauss B
FAU - Wanner, Guido A
AU  - Wanner GA
FAU - Csuka, Esther
AU  - Csuka E
FAU - Payne, Barbara
AU  - Payne B
FAU - Frauenfelder, Thomas
AU  - Frauenfelder T
FAU - Andreisek, Gustav
AU  - Andreisek G
FAU - Alkadhi, Hatem
AU  - Alkadhi H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120508
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adult
MH  - Algorithms
MH  - Ankle Injuries/*pathology
MH  - Bone Marrow/*pathology
MH  - Female
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - ROC Curve
MH  - Sensitivity and Specificity
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2012/05/10 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/05/10 06:00
PHST- 2012/05/10 06:00 [entrez]
PHST- 2012/05/10 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
AID - radiol.12112217 [pii]
AID - 10.1148/radiol.12112217 [doi]
PST - ppublish
SO  - Radiology. 2012 Jul;264(1):164-73. doi: 10.1148/radiol.12112217. Epub 2012 May 8.


PMID- 22570504
OWN - NLM
STAT- MEDLINE
DCOM- 20120920
LR  - 20161125
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Linking)
VI  - 264
IP  - 1
DP  - 2012 Jul
TI  - Sudden death after chest pain: feasibility of virtual autopsy with postmortem CT 
      angiography and biopsy.
PG  - 250-9
LID - 10.1148/radiol.12092415 [doi]
AB  - PURPOSE: To determine the potential of minimally invasive postmortem computed
      tomographic (CT) angiography combined with image-guided tissue biopsy of the
      myocardium and lungs in decedents who were thought to have died of acute chest
      disease and to compare this method with conventional autopsy as the reference
      standard. MATERIALS AND METHODS: The responsible justice department and ethics
      committee approved this study. Twenty corpses (four female corpses and 16 male
      corpses; age range, 15-80 years), all of whom were reported to have had
      antemortem acute chest pain, were imaged with postmortem whole-body CT
      angiography and underwent standardized image-guided biopsy. The standard included
      three biopsies of the myocardium and a single biopsy of bilateral central lung
      tissue. Additional biopsies of pulmonary clots for differentiation of pulmonary
      embolism and postmortem organized thrombus were performed after initial analysis 
      of the cross-sectional images. Subsequent traditional autopsy with sampling of
      histologic specimens was performed in all cases. Thereafter, conventional
      histologic and autopsy reports were compared with postmortem CT angiography and
      CT-guided biopsy findings. A Cohen kappa coefficient analysis was performed to
      explore the effect of the clustered nature of the data. RESULTS: In 19 of the 20 
      cadavers, findings at postmortem CT angiography in combination with CT-guided
      biopsy validated the cause of death found at traditional autopsy. In one cadaver,
      early myocardial infarction of the papillary muscles had been missed. The Cohen
      kappa coefficient was 0.94. There were four instances of pulmonary embolism,
      three aortic dissections (Stanford type A), three myocardial infarctions, three
      instances of fresh coronary thrombosis, three cases of obstructive coronary
      artery disease, one ruptured ulcer of the ascending aorta, one ruptured aneurysm 
      of the right subclavian artery, one case of myocarditis, and one pulmonary
      malignancy with pulmonary artery erosion. In seven of 20 cadavers, CT-guided
      biopsy provided additional histopathologic information that substantiated the
      final diagnosis of the cause of death. CONCLUSION: Postmortem CT angiography
      combined with image-guided biopsy, because of their minimally invasive nature,
      have a potential role in the detection of the cause of death after acute chest
      pain.
CI  - (c) RSNA, 2012.
FAU - Ross, Steffen G
AU  - Ross SG
AD  - Centre for Forensic Imaging and Virtopsy, Institute of Forensic Medicine,
      University of Berne, Bern, Switzerland.
FAU - Thali, Michael J
AU  - Thali MJ
FAU - Bolliger, Stephan
AU  - Bolliger S
FAU - Germerott, Tanja
AU  - Germerott T
FAU - Ruder, Thomas D
AU  - Ruder TD
FAU - Flach, Patricia M
AU  - Flach PM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20120508
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Autopsy/*methods
MH  - Biopsy/*methods
MH  - Cadaver
MH  - Cause of Death
MH  - Chest Pain/diagnostic imaging/*mortality
MH  - *Death, Sudden, Cardiac
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Radiography, Interventional/*methods
MH  - Tomography, X-Ray Computed/*methods
EDAT- 2012/05/10 06:00
MHDA- 2012/09/21 06:00
CRDT- 2012/05/10 06:00
PHST- 2012/05/10 06:00 [entrez]
PHST- 2012/05/10 06:00 [pubmed]
PHST- 2012/09/21 06:00 [medline]
AID - radiol.12092415 [pii]
AID - 10.1148/radiol.12092415 [doi]
PST - ppublish
SO  - Radiology. 2012 Jul;264(1):250-9. doi: 10.1148/radiol.12092415. Epub 2012 May 8.


PMID- 22570158
OWN - NLM
STAT- MEDLINE
DCOM- 20120919
LR  - 20120509
IS  - 1439-1309 (Electronic)
IS  - 0034-3536 (Linking)
VI  - 51
IP  - 2
DP  - 2012 Apr
TI  - [Risks and chances of prioritization].
PG  - 107-10
LID - 10.1055/s-0032-1306291 [doi]
AB  - Priority setting in medicine is associated with potential risks which can be
      avoided. The most important positive and negative factors influencing the
      discussion in other countries are specified. A diligent, well-balanced,
      off-limited, open-ended, and straightforward discussion which is picked up in due
      time comprises great chances for a consensual debate to further develop health
      care settings to the benefit of all citizens. This debate may advance
      considerably using terms correctly, respecting legitimacy and social justice,
      ensuring ethical fundamentals as well as transparency towards the general public.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Seger, W
AU  - Seger W
AD  - Medizinischer Dienst der Krankenversicherung Niedersachsen, Hannover.
      wolfgang.seger@MDKN.de
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Allgemeine Risiken und Chancen der Priorisierung.
DEP - 20120508
PL  - Germany
TA  - Rehabilitation (Stuttg)
JT  - Die Rehabilitation
JID - 0401273
SB  - IM
MH  - Delivery of Health Care/*organization & administration
MH  - Germany
MH  - Health Care Rationing/*methods/*organization & administration
MH  - Health Priorities/*organization & administration
MH  - *Models, Organizational
MH  - National Health Programs/*organization & administration
MH  - Organizational Objectives
MH  - Rehabilitation/*organization & administration
MH  - Risk Assessment
EDAT- 2012/05/10 06:00
MHDA- 2012/09/20 06:00
CRDT- 2012/05/10 06:00
PHST- 2012/05/10 06:00 [entrez]
PHST- 2012/05/10 06:00 [pubmed]
PHST- 2012/09/20 06:00 [medline]
AID - 10.1055/s-0032-1306291 [doi]
PST - ppublish
SO  - Rehabilitation (Stuttg). 2012 Apr;51(2):107-10. doi: 10.1055/s-0032-1306291. Epub
      2012 May 8.


PMID- 22570156
OWN - NLM
STAT- MEDLINE
DCOM- 20120919
LR  - 20120509
IS  - 1439-1309 (Electronic)
IS  - 0034-3536 (Linking)
VI  - 51
IP  - 2
DP  - 2012 Apr
TI  - [Helping as a matter of expedience? Ethical objections against prioritization in 
      medicine].
PG  - 96-102
LID - 10.1055/s-0032-1306292 [doi]
AB  - The paper discusses the question whether it could be ethically appropriate to
      "resolve" the problem of scarce resources in health care via priority lists. It
      is argued that such a schematical priority list could only be undisputed in
      ethical respects if it represented a broad consensus on the question what a good 
      life would be. Priority lists are always implicit decisions about specific
      concepts of the good life. Using a priority list only in consideration of a mere 
      cost-benefit ratio means to accept a mere utilitarian way of defining good life. 
      Such a definition goes with neglect of the interests of people with chronic
      diseases, of patients with incurable diseases, of patients with a limited life
      expectancy. To neglect the interests of these patients means to abandon the core 
      of medical identity, because medicine has the mission to help those above all who
      are most in need and those who cannot help themselves. And so we have to realize 
      that for medicine there are some values which are more important than economic
      considerations. The physician is a person who gives a promise, the promise to be 
      there for the patient. If the physician now is becoming a businessman, this
      promise is no longer valid. The businessman doesn't give any other promise than
      not to act against the contract. But the main need of the patient, his longing
      for a human person whom he can trust, cannot become part of a contract.
      Especially in our time medicine has to fight for the core of its identity.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Maio, G
AU  - Maio G
AD  - Institut fur Ethik und Geschichte der Medizin, Albert-Ludwigs-Universitat
      Freiburg. maio@ethik.uni-freiburg.de
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Helfen nach Berechnung? Ethische Einwande gegen die Priorisierung in der Medizin.
DEP - 20120508
PL  - Germany
TA  - Rehabilitation (Stuttg)
JT  - Die Rehabilitation
JID - 0401273
SB  - IM
MH  - Delivery of Health Care/*ethics/organization & administration
MH  - Germany
MH  - Health Care Rationing/*ethics
MH  - Health Priorities/*ethics/organization & administration
MH  - *Models, Organizational
MH  - National Health Programs/*ethics
MH  - Organizational Objectives
MH  - Rehabilitation/*ethics/organization & administration
EDAT- 2012/05/10 06:00
MHDA- 2012/09/20 06:00
CRDT- 2012/05/10 06:00
PHST- 2012/05/10 06:00 [entrez]
PHST- 2012/05/10 06:00 [pubmed]
PHST- 2012/09/20 06:00 [medline]
AID - 10.1055/s-0032-1306292 [doi]
PST - ppublish
SO  - Rehabilitation (Stuttg). 2012 Apr;51(2):96-102. doi: 10.1055/s-0032-1306292. Epub
      2012 May 8.


PMID- 22569314
OWN - NLM
STAT- MEDLINE
DCOM- 20120918
LR  - 20120530
IS  - 1473-6578 (Electronic)
IS  - 0951-7367 (Linking)
VI  - 25
IP  - 4
DP  - 2012 Jul
TI  - Children and young people in immigration detention.
PG  - 285-92
LID - 10.1097/YCO.0b013e3283548676 [doi]
AB  - PURPOSE OF REVIEW: This article reviews evidence about the impact of immigration 
      detention and other restrictive immigration policies on the mental health of
      children, young people and the adults who care for them. We review the
      implications of this for clinicians attempting to assess or work with
      incarcerated child and adult refugees and asylum seekers. RECENT FINDINGS: There 
      are increasing numbers of adults and children seeking asylum across the globe and
      many nations use incarceration and other harsh and interceptive immigration
      practices. There is mounting evidence of the psychological harm associated with
      detention of already vulnerable adults and children. Australia is used as a case 
      study. SUMMARY: Clinicians are required to consider the intersection of mental
      health assessment and treatment with human rights violations, and the impact of
      restrictive immigration policies, not only on asylum seekers and refugees but
      also on clinicians, clinical practice and professional ethics.
FAU - Dudley, Michael
AU  - Dudley M
AD  - Sydney Children's Hospital, School of Psychiatry, University of NSW, Sydney, NSW,
      Australia. m.dudley@unsw.edu.au
FAU - Steel, Zachary
AU  - Steel Z
FAU - Mares, Sarah
AU  - Mares S
FAU - Newman, Louise
AU  - Newman L
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Psychiatry
JT  - Current opinion in psychiatry
JID - 8809880
SB  - IM
MH  - Adolescent
MH  - Australia
MH  - Child
MH  - Child, Preschool
MH  - Developmental Disabilities/etiology
MH  - Emigrants and Immigrants/*psychology
MH  - Female
MH  - Human Rights Abuses/psychology
MH  - Humans
MH  - Male
MH  - Mental Disorders/*etiology
MH  - *Mental Health
MH  - Prisoners/*psychology
MH  - Refugees/*psychology
MH  - Stress, Psychological/etiology
MH  - Young Adult
EDAT- 2012/05/10 06:00
MHDA- 2012/09/19 06:00
CRDT- 2012/05/10 06:00
PHST- 2012/05/10 06:00 [entrez]
PHST- 2012/05/10 06:00 [pubmed]
PHST- 2012/09/19 06:00 [medline]
AID - 10.1097/YCO.0b013e3283548676 [doi]
PST - ppublish
SO  - Curr Opin Psychiatry. 2012 Jul;25(4):285-92. doi: 10.1097/YCO.0b013e3283548676.


PMID- 22569285
OWN - NLM
STAT- MEDLINE
DCOM- 20121231
LR  - 20120806
IS  - 1559-713X (Electronic)
IS  - 1559-2332 (Linking)
VI  - 7
IP  - 4
DP  - 2012 Aug
TI  - "This is a decision you have to make": using simulation to study prenatal
      counseling.
PG  - 207-12
LID - 10.1097/SIH.0b013e318256666a [doi]
AB  - INTRODUCTION: Prenatal decision making during extremely preterm labor is
      challenging for parents and physicians. Ethical and logistical concerns have
      limited empirical descriptions of physician counseling behaviors in this setting 
      and constricted opportunities for communication training. This pilot study
      examines how simulation might be used to engage neonatologists in reflecting on
      their usual prenatal counseling behaviors. METHODS: Neonatology physicians
      counseled a couple (standardized patients) with the female patient having
      impending delivery at 23 3/7 weeks. Encounters were videotaped. Physicians
      completed postencounter surveys and debriefing interviews. Mixed-methods analysis
      explored the outcomes of clinical verisimilitude and counseling behaviors.
      RESULTS: All 10 neonatology physicians found that the simulation was highly
      realistic and that their behaviors paralleled neonatologist self-report in other 
      studies. Physicians contributed more than 80% of encounter dialogue and mostly
      focused on biomedical information related to the acute perinatal period.
      Physicians spent nearly a quarter of each encounter in building relationships and
      expressing empathy. Most physicians initiated discussion about quality versus
      quantity of life but infrequently elicited the parents' related goals and values.
      When medical factors and family preferences were held constant, physicians
      assumed variable responsibility for making decisions about resuscitation. Most
      physicians declined parent requests for treatment recommendations, although all
      of those physicians felt more than 75% certain about what should be done.
      CONCLUSIONS: Simulation can reproduce the decisional context of prenatal
      counseling for extremely premature labor. These results have implications for
      communication training in any setting where physicians and patients without
      established relationships must discuss acute diagnoses and make high-stakes
      medical decisions.
FAU - Boss, Renee D
AU  - Boss RD
AD  - Division of Neonatology, Department of Pediatrics, Johns Hopkins University
      School of Medicine, Baltimore, MD 21205, USA. rboss1@jhmi.edu
FAU - Donohue, Pamela K
AU  - Donohue PK
FAU - Roter, Debra L
AU  - Roter DL
FAU - Larson, Susan M
AU  - Larson SM
FAU - Arnold, Robert M
AU  - Arnold RM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Simul Healthc
JT  - Simulation in healthcare : journal of the Society for Simulation in Healthcare
JID - 101264408
SB  - IM
MH  - Adult
MH  - *Clinical Competence
MH  - Communication
MH  - *Decision Making
MH  - *Directive Counseling
MH  - Empathy
MH  - Female
MH  - Goals
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Male
MH  - Middle Aged
MH  - *Neonatology
MH  - Physician-Patient Relations
MH  - Pilot Projects
MH  - Pregnancy
MH  - Prenatal Care/*methods
MH  - Resuscitation/methods
MH  - Self Report
EDAT- 2012/05/10 06:00
MHDA- 2013/01/01 06:00
CRDT- 2012/05/10 06:00
PHST- 2012/05/10 06:00 [entrez]
PHST- 2012/05/10 06:00 [pubmed]
PHST- 2013/01/01 06:00 [medline]
AID - 10.1097/SIH.0b013e318256666a [doi]
PST - ppublish
SO  - Simul Healthc. 2012 Aug;7(4):207-12. doi: 10.1097/SIH.0b013e318256666a.


PMID- 22569123
OWN - NLM
STAT- MEDLINE
DCOM- 20130822
LR  - 20220311
IS  - 1471-2407 (Electronic)
IS  - 1471-2407 (Linking)
VI  - 12
DP  - 2012 May 8
TI  - TARGIT-E(lderly)--prospective phase II study of intraoperative radiotherapy
      (IORT) in elderly patients with small breast cancer.
PG  - 171
LID - 10.1186/1471-2407-12-171 [doi]
AB  - BACKGROUND: Patients >/= 70 years with small, low-risk breast cancer who are
      operated but not irradiated how local relapse rates around 4% after 4 years. With
      adjuvant whole breast radiotherapy (WBRT) the local relapse rate drops to 1%
      after 4 years under Tamoxifen. It has been demonstrated that the efficacy of
      radiotherapy of the tumor bed only in a selected group can be non-inferior to
      WBRT. METHODS/DESIGN: This prospective, multicentric single arm phase II study is
      based on the protocol of the international TARGIT-A study. The TARGIT-E study
      should confirm the efficacy of a single dose of intraoperative radiotherapy
      (IORT) in a well selected group of elderly patients with small breast cancer and 
      absence of risk factors. Patients will receive IORT (20 Gy with Intrabeam
      system/Carl Zeiss) during breast conserving surgery. In presence of risk factors 
      postoperative WBRT will be added to complete the radiotherapeutic treatment
      according to international guidelines. Endpoints are the local relapse rate
      (within 2 cm of the tumor bed), ipsilateral in breast relapse, cancer-specific
      and overall survival and contralateral breast cancer as well as documentation of 
      quality of life and cosmetic outcome.The expected local relapse rates are
      0.5/1/1.5% after 2.5/5/7.5 years, respectively. Discontinuation of the trial is
      scheduled if rates of local relapse rates rise to 3/4/6% after 2.5/5/7.5 years.
      Power calculations result in 540 patients with a calculated dropout rate of 20%
      and loss to follow-up of 20%, an alpha of 0.01 and a beta 0.05. There will be a
      pre- and a post-pathology stratum (n = 270 each). DISCUSSION: It is a pragmatic
      trial in which each participating centre has the option to modify entry criteria 
      and criteria for WBRT according to this core protocol after consultation with the
      steering committee and local ethics committee (e.g. size, free margins). Only
      centers with access to the Intrabeam system (Carl Zeiss) can recruit patients
      into the trial.Its aim is to confirm the efficacy and toxicity of IORT in a well 
      selected collective of elderly patients with breast cancer. TRIAL REGISTRATION:
      [corrected] NCT01299987.
FAU - Neumaier, Christian
AU  - Neumaier C
AD  - Department of Radiation Oncology, University Medical Centre Mannheim, University 
      of Heidelberg, Theodor-Kutzer-Ufer 1-3, Mannheim, 68167, Germany.
      christian.neumaier@umm.de
FAU - Elena, Sperk
AU  - Elena S
FAU - Grit, Welzel
AU  - Grit W
FAU - Yasser, Abo-Madyan
AU  - Yasser AM
FAU - Uta, Kraus-Tiefenbacher
AU  - Uta KT
FAU - Anke, Keller
AU  - Anke K
FAU - Axel, Gerhardt
AU  - Axel G
FAU - Marc, Sutterlin
AU  - Marc S
FAU - Frederik, Wenz
AU  - Frederik W
LA  - eng
SI  - ClinicalTrials.gov/NCT01299987
PT  - Clinical Trial, Phase II
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20120508
PL  - England
TA  - BMC Cancer
JT  - BMC cancer
JID - 100967800
RN  - 094ZI81Y45 (Tamoxifen)
SB  - IM
MH  - Aged
MH  - Breast Neoplasms/drug therapy/pathology/*radiotherapy/*surgery
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Intraoperative Care/adverse effects/*methods
MH  - Mastectomy, Segmental/adverse effects/methods
MH  - Prospective Studies
MH  - Quality of Life
MH  - Radiotherapy Dosage
MH  - Radiotherapy, Adjuvant/adverse effects/methods
MH  - Tamoxifen/therapeutic use
MH  - Treatment Outcome
PMC - PMC3519765
EDAT- 2012/05/10 06:00
MHDA- 2013/08/24 06:00
CRDT- 2012/05/10 06:00
PHST- 2011/12/14 00:00 [received]
PHST- 2012/03/07 00:00 [accepted]
PHST- 2012/05/10 06:00 [entrez]
PHST- 2012/05/10 06:00 [pubmed]
PHST- 2013/08/24 06:00 [medline]
AID - 1471-2407-12-171 [pii]
AID - 10.1186/1471-2407-12-171 [doi]
PST - epublish
SO  - BMC Cancer. 2012 May 8;12:171. doi: 10.1186/1471-2407-12-171.


PMID- 22569028
OWN - NLM
STAT- MEDLINE
DCOM- 20121217
LR  - 20220317
IS  - 1365-2346 (Electronic)
IS  - 0265-0215 (Linking)
VI  - 29
IP  - 9
DP  - 2012 Sep
TI  - Deficits in information transfer between anaesthesiologist and postanaesthesia
      care unit staff: an analysis of patient handover.
PG  - 438-45
LID - 10.1097/EJA.0b013e3283543e43 [doi]
AB  - BACKGROUND: The immediate postoperative period is important, as the patient
      recovers from the acute derangements resulting from the surgical insult and
      anaesthesia. Incomplete or incorrect communication between the anaesthesiologist 
      and the postanaesthesia care unit nurse during the transfer process may lead to
      dangerous clinical mistakes. The literature examining handovers from operating
      room to the postanaesthesia care unit is scarce. OBJECTIVES: The primary
      objective of this study was to examine the current transfer practice through
      observation of handovers between the anaesthesiologists and the postanaesthesia
      care unit staff in order to identify data omissions. The secondary objective was 
      to learn which data items the clinicians and nurses thought were a necessary part
      of the transfer process and whether this information was communicated at the time
      of handover. DESIGN: A prospective observational study. SETTING: Academic
      hospital in Toronto, Canada. PARTICIPANTS AND INTERVENTIONS: After Research
      Ethics Board approval, a prospective observational study was conducted at a
      university-affiliated teaching centre. During a 2-month period, multiple
      observations of patient handover were performed. The data provided were marked on
      a checklist. At the end of the study, participating nurses and physicians were
      surveyed regarding the necessity of communicating different items on the
      checklist. RESULTS: A total of 526 transfers were observed. Of 29 data items
      examined, only two items (type of surgery and analgesics given) were reported in 
      more than 90% of handovers. Only three items (difficult intubation, ST-wave
      changes and co-morbidities/healthy) were reported in more than 80% of cases. Many
      items deemed as needed to be reported by the participants in the study were not
      communicated. CONCLUSION: This study demonstrates that the handover process is
      inconsistent and in some cases information defined as important by the physicians
      and the nurses is not transferred. Further studies need to investigate whether a 
      handover protocol leads to a minimisation of omissions in information transfer.
FAU - Siddiqui, Naveed
AU  - Siddiqui N
AD  - Department of Anaesthesia and Pain Management, Mount Sinai Hospital, University
      of Toronto, Toronto, Ontario, Canada. naveed.siddiqui@uhn.ca
FAU - Arzola, Cristian
AU  - Arzola C
FAU - Iqbal, Mirza
AU  - Iqbal M
FAU - Sritharan, Kobika
AU  - Sritharan K
FAU - Guerina, Laarni
AU  - Guerina L
FAU - Chung, Frances
AU  - Chung F
FAU - Friedman, Zeev
AU  - Friedman Z
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur J Anaesthesiol
JT  - European journal of anaesthesiology
JID - 8411711
SB  - IM
MH  - Adult
MH  - Anesthesia Recovery Period
MH  - *Anesthesiology
MH  - *Communication
MH  - *Continuity of Patient Care
MH  - Humans
MH  - Middle Aged
MH  - *Patient Transfer
MH  - Prospective Studies
MH  - Recovery Room
EDAT- 2012/05/10 06:00
MHDA- 2012/12/18 06:00
CRDT- 2012/05/10 06:00
PHST- 2012/05/10 06:00 [entrez]
PHST- 2012/05/10 06:00 [pubmed]
PHST- 2012/12/18 06:00 [medline]
AID - 10.1097/EJA.0b013e3283543e43 [doi]
PST - ppublish
SO  - Eur J Anaesthesiol. 2012 Sep;29(9):438-45. doi: 10.1097/EJA.0b013e3283543e43.


PMID- 22568978
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1753-2000 (Electronic)
IS  - 1753-2000 (Linking)
VI  - 6
IP  - 1
DP  - 2012 Jul 9
TI  - The ethical landscape of professional care in everyday practice as perceived by
      staff: A qualitative content analysis of ethical diaries written by staff in
      child and adolescent psychiatric in-patient care.
PG  - 18
LID - 10.1186/1753-2000-6-18 [doi]
AB  - BACKGROUND: Although there has been some empirical research on ethics concerning 
      the attitudes and approaches of staff in relation to adult patients, there is
      very little to be found on child and adolescent psychiatric care. In most cases
      researchers have defined which issues are important, for instance, coercive care.
      The aim of this study was to provide a qualitative description of situations and 
      experiences that gave rise to ethical problems and considerations as reported by 
      staff members on child and adolescent psychiatric wards, although they were not
      provided with a definition of the concept. METHODS: The study took place in six
      child and adolescent psychiatric wards in Sweden. All staff members involved with
      patients on these wards were invited to participate. The staff members were asked
      to keep an ethical diary over the course of one week, and data collection
      comprised the diaries handed in by 68 persons. Qualitative content analysis was
      used in order to analyse the diaries. RESULTS: In the analysis three themes
      emerged; 1) good care 2) loyalty and 3) powerlessness. The theme 'good care'
      contains statements about the ideal of commitment but also about problems living 
      up to the ideal. Staff members emphasized the importance of involving patients
      and parents in the care, but also of the need for professional distance.
      Participants seldom perceived decisions about coercive measures as problematic,
      in contrast to those about pressure and restrictions, especially in the case of
      patients admitted for voluntary care. The theme 'loyalty' contains statements in 
      which staff members perceived contradictory expectations from different
      interested parties, mainly parents but also their supervisor, doctors, colleagues
      and the social services. The theme 'powerlessness' contains statements about
      situations that create frustration, in which freedom of action is perceived as
      limited and can concern inadequacy in relation to patients and violations in the 
      workplace. CONCLUSIONS: The ethical considerations described by child and
      adolescent psychiatric care staff are multifaceted and remarkably often concern
      problems of loyalty and organization. These problems frequently had a
      considerable influence on the care provided. It seems that staff members lack a
      language of ethics and require both an ethical education and a forum for
      discussion of ethical issues.
FAU - Pelto-Piri, Veikko
AU  - Pelto-Piri V
AD  - Psych